bluuebunny/crossref_metadata_2025 huggingface dataset:
Renal Interstitial Fibrosis Is Reduced in High-Fat Diet-Induced Obese Pigs following Renal Denervation from the Intima and Adventitia of the Renal Artery
Authors: Zhu Binbin , Liu Yahui , Qi Datun , Zhao Linwei , Yang Xiaohang , Su Enyong , Zhu Zhongyu , Zhang You , Gao Chuanyu
Published: December 2021

Background: This study aims to compare whether 2 different routes of renal denervation (RDN) from the intima and adventitia of the renal artery can reduce renal fibrosis in a pig model of hypertension induced by a high-fat diet and to explore possible molecular mechanisms. Methods: Twenty-four Bama miniature pigs were randomly divided into a control group (normal diet, n = 6) or a hypertension model group (high-fat diet, n = 18). The model group was randomly divided into the intima-RDN group (n = 6), the adventitia-RDN group (n = 6), or the renal arteriography-only group (sham group, n = 6). All animals were fed separately. The model group was fed a high-fat diet after the operation, and the control group was fed conventionally for 6 months. After 6 months, renal artery angiography was performed again to observe the condition of the renal arteries, after which all animals were euthanized. The blood pressure and blood biochemical results of each group were evaluated 6 months after the operation; kidney tissue morphology and collagen fiber content were examined by hematoxylin-eosin staining and Masson staining; superoxide dismutase activity and the malondialdehyde content of kidney tissue were assessed by a biochemical enzyme method; the protein expression level of transforming growth factor-β 1 (TGF-β1), α-smooth muscle actin (α-SMA), and Smad3 was assessed by Western blot, and electron microscopy was used to examine changes in the kidney microstructure. Results: After 6 months of a high-fat diet, the blood lipid levels of the model group were significantly higher compared to baseline and to that of the control group during the same period (all showed p < 0.05); the blood lipid levels of the control group did not change significantly from baseline (p > 0.05). The degree of glomerular damage caused by hyperlipidemia in the intima-RDN group and the adventitia-RDN group was significantly lower than that of the sham and control groups, and the renal fibrosis area percentage was also significantly lower (p < 0.05). Electron microscopy showed that both the intima-RDN group and the adventitia-RDN group had a more even distribution of chromosomes and less mitochondrial swelling compared with the sham group. Conclusion: RDN from the adventitia of the renal artery and RDN from the intima of the renal artery have the similar advantages of delaying high-fat-induced renal fibrosis. The antifibrotic effect of RDN may be related to inhibition of the TGF-β1/Smad3 pathway.
Substrate Characterization and Outcome of Catheter Ablation of Ventricular Tachycardia in Patients With Nonischemic Cardiomyopathy and Isolated Epicardial Scar
Authors: Liuba Ioan , Muser Daniele , Chahal Anwar , Tschabrunn Cory , Santangeli Pasquale , Kuo Ling , Frankel David S. , Callans David J. , Garcia Fermin , Supple Gregory E. , Schaller Robert D. , Dixit Sanjay , Lin David , Nazarian Saman , Kumareswaran Ramanan , Arkles Jeffrey , Riley Michael P. , Hyman Matthew C. , Walsh Katie , Guandalini Gustavo , Arceluz Martin , Pothineni Naga Venkata K. , Zado Erica S. , Marchlinski Francis
Published: December 2021

Background:

The substrate for ventricular tachycardia (VT) in left ventricular (LV) nonischemic cardiomyopathy may be epicardial. We assessed the prevalence, location, endocardial electrograms, and VT ablation outcomes in LV nonischemic cardiomyopathy with isolated epicardial substrate.

Methods:

Forty-seven of 531 (9%) patients with LV nonischemic cardiomyopathy and VT demonstrated normal endocardial (>1.5 mV)/abnormal epicardial bipolar low-voltage area (LVA, <1.0 mV and signal abnormality). Abnormal endocardial unipolar LVA (≤8.3 mV) and endocardial bipolar split electrograms and predictors of ablation success were assessed.

Results:

Epicardial bipolar LVA (27.3 cm
2
[interquartile range, 15.8–50.0]) localized to basal (40), mid (8), and apical (3) LV with basal inferolateral LV most common (28/47, 60%). Of 44 endocardial maps available, 40 (91%) had endocardial unipolar LVA (24.5 cm
2
[interquartile range, 9.4–68.5]) and 29 (67%) had characteristic normal amplitude endocardial split electrograms opposite the epicardial LVA. At mean of 34 months, the VT-free survival was 55% after one and 72% after multiple procedures. Greater endocardial unipolar LVA than epicardial bipolar LVA (hazard ratio, 10.66 [CI, 2.63–43.12],
P
=0.001) and number of inducible VTs (hazard ratio, 1.96 [CI, 1.27–3.00],
P
=0.002) were associated with VT recurrence.

Conclusions:

In patients with LV nonischemic cardiomyopathy and VT, the substrate may be confined to epicardial and commonly basal inferolateral. LV endocardial unipolar LVA and normal amplitude bipolar split electrograms identify epicardial LVA. Ablation targeting epicardial VT and substrate achieves good long-term VT-free survival. Greater endocardial unipolar than epicardial bipolar LVA and more inducible VTs predict VT recurrence.
A Case of Kinship
Authors: van de Poel Rita , Stolk Sander
Published: December 2021

This article describes onomasiological explorations of Old Frisian and Old English lexis in the semantic field of KINSHIP through a novel, digital approach. In connecting Old Frisian lexis, drawn from the Altfriesisches Handwörterbuch (AFWB), to the overarching structure of A Thesaurus of Old English (TOE), a dataset has been created that shares a semantic framework with the one existing for Old English lexis. The connected resources are shared and analysed using the web application Evoke. Statistical data provided by this tool, such as the degree of lexicalization for this field, facilitates comparative analyses of the two historical languages. As this article demonstrates, the reuse of the onomasiological macrostructure of TOE offers new insights into linguistic and cultural aspects of these two languages and their language communities.
The Causative Stem in Soqotri
Authors: Bulakh M. , Kogan L. , Issa A. , Gumaan I. , Mohammed M.
Published: December 2021

Soqotri is an understudied Semitic language belonging to the Modern South Arabian branch and spoken by the approximately 100,000 inhabitants of the island of Soqotra. The present contribution offers a list of verbs belonging to the so-called causative stem in Soqotri (a cognate of the Arabic stem IV), based on the analysis of the data in the two recently published volumes of the Soqotri oral literature as well as the fieldwork notes of the authors.
Citizen experts in participatory governance: Democratic and epistemic assets of service user involvement, local knowledge and citizen science
Authors: Krick Eva
Published: December 2021

Initiatives that attribute expert status to ‘ordinary citizens’ proliferate in a range of societal realms and are generally celebrated for ‘democratising expertise’. By tapping new sources of knowledge and participation simultaneously, such ‘citizen expertise’ practices seem to provide responses to the contemporary decline of trust in political elites and traditional experts that seriously challenges the legitimacy of democratic policy-making. This study distinguishes between three quintessential types of citizen expertise (‘local knowledge’, ‘service user involvement’ and ‘citizen science’) and, from an integrated perspective, critically discusses the value of citizen expertise for public knowledge production and democratic governance. Drawing on empirical insights and on theories of democracy and of expertise and knowledge, the concepts of expertise and participation are refined and quality conditions of citizen expertise are developed. The study argues that citizen expertise is epistemically particularly valuable when it is based on distinct, non-ubiquitous experiences and on collective, not just individual, insights. It contends that representativeness is key to the democratic legitimacy of citizen experts in the policy context and points to the key role of organised civil society in establishing the required accountability relationships.
Conditional Consent and Sexual Crime: Time for Reform?
Authors: Alencar Ticiana
Published: December 2021

Statistics published by the government in 2021 highlight serious problems in England and Wales with a drop in prosecutions of sexual crimes. Part of this issue is attributed to the complexities around sexual consent and public understanding of it. This article highlights a particular problem in the law around conditional consent. It shows that the law on conditional consent is completely incoherent, complicating efforts to increase public education on the matter. The law is also limited in its protection of sexual autonomy of victims, as well in its protection of victims against pregnancy. Critics of reform warn against overcriminalisation of rape, and against imposing morals on society. However, it is argued that given the current reality of how rape is dealt with in England and Wales, these concerns should not prevent reform to the law of conditional consent. The article ends by arguing that reform should be carried out to make the law on conditional consent more coherent and to take account of pregnancy as a consequence of sexual intercourse.
Transcatheter closure of multiple paravalvular leaks by a transapical approach under echocardiographic guidance: A case report
Authors: Yi Kang , Ding Fang-Hui , You Tao , Li Hong-Xin , Xu Jian-Guo , Hou Xiao-Dong , Wang Xin-Kuan , Zhang Xin
Published: December 2021

Case summary

A patient who underwent mechanical aortic and mitral valve replacement developed three paravalvular leaks 10 months later. We located the tracks by puncturing the apex cordis under transoesophageal echocardiography guidance alone and puncturing the femoral artery guided by fluoroscopy. Three paravalvular leaks were occluded with a hybridization method simultaneously. The patient was followed up for 24 months and maintained a good condition.

Conclusion

Multiple paravalvular leaks after double valve replacement can be occluded in patients by the use of different approaches under echocardiographic guidance alone.
From fabric to smart T-shirt: fine tuning an improved robust system to detect arrhythmia
Authors: Malek Abdel Salam , Elnahrawy Ashraf , Anwar Hamed , Naeem Mohamed
Published: December 2021

Wearable electrocardiogram (ECG) systems should be comfortable, non-stigmatizing, and capable of producing high-quality data. Many different designs of wearable textile ECG systems have recently emerged. Some of them are not considered to be smart garments, whereas most of the others present only the electronic side of the system. Our research work introduces a comprehensive study for an improved single-lead ECG smart shirt to identify automatically premature ventricular contraction as a common form of arrhythmia.

For artifact-free results, Marvelous Designer is implemented to design our optimized relaxed slim fit shirt. In addition, a weft-knitted fabric of 80% nylon–20% spandex is used to manufacture the outer part of the shirt.

Moreover, lightweight and small size electronic components are integrated to the outer part via low-resistance dry textile electrodes and 100% cotton fabric as an inner layer for easy transmission of weak ECG signals.
Marriage, the New Testament, and pastoral ministry
Authors: Thatcher Adrian
Published: December 2021

There is a diversity of teaching about marriage in the New Testament. Opening up this diversity provides a pastorally more generous, and theologically more adequate, understanding of marriage than claiming, and then finding, an alleged unanimity of view. The article considers, in chronological order, the teaching of Paul, the teaching of Jesus in the Gospels, and the teaching of the later Letters on marriage, acknowledging the differences. It then suggests several pastoral benefits for ministry arising from the acknowledgement of the diversity of teaching.
Can India’s Higher Education Improve Through Better Management of Human Resources: A Comparative Study of India and the United States
Authors: Pandit Jai Mohan , Paul Bino
Published: December 2021

This study investigates human resource management (HRM) practices in higher education institutions (HEIs) based on a comparative analysis of India and the US. Although higher education in India has grown over the decades, its quality, in general, has not kept up with global standards. On the other hand, many US universities have performed consistently well in international university rankings. Based on qualitative research collected from principal stakeholders of HEIs in India and the US, HRM practices and policies followed by them are presented and discussed. Data collection for the research study was through web interviews during the period August–October 2020. The study reveals that Indian public HEIs do not have professional HRM teams. Also, they are in a formative stage in autonomous and private institutions. On the other hand, many HEIs in the US have developed mature HRM systems. This difference resonates in attributes such as structure of HRM, recruitment and selection processes, training and development programmes, performance management, career progression and talent retention.
What is NORML? Sedimented Meanings in Ambiguous Organizational Identities
Authors: Lyle Matthew C.B. , Walsh Ian J. , Coraiola Diego M.
Published: December 2021

Organizational identity scholarship has largely focused on the mutability of meanings ascribed to ambiguous identity labels. In contrast, we analyze a case study of the National Organization for the Reform of Marijuana Laws (NORML) to explore how leaders maintained a meaning ascribed to an ambiguous identity label amid successive identity threats. We found that heightened dissensus surrounding meanings attributed to the organization’s “reform group” label at three key points spurred theoretically similar manifestations of two processes. The first, meaning sedimentation, involved leaders invoking history to advocate for the importance of their preferred meaning while mulling the inclusion of others. The second, reconstructing the past, occurred as leaders and members alike offered narratives that obscured the history of disavowed meanings while sharing new memories of those they prioritized. Our work complements research on identity change by drawing attention to the processes by which meaning(s) underlying ambiguous identity labels might survive.
Association of endothelial nitric oxide synthase intron 4a/b gene polymorphisms and hypertension: a systematic review and meta-analysis
Authors: Xu Xiru , Ye Woruo , Chen Hanqing , Liu Ming , Jiang Weimin , Fang Zhuyuan
Published: December 2021

Objective

We conducted meta-analysis of relevant case-control trials to determine the association between endothelial nitric oxide synthase (eNOS) intron 4a/b gene polymorphisms and hypertension susceptibility.

Methods

We searched the PubMed, Cochrane, and Embase databases using relevant keywords and reviewed pertinent literature sources. All articles published up to July 2019 were considered for inclusion. Based on the qualified studies, we performed a meta-analysis of the associations between eNOS intron 4a/b polymorphisms and the risk of hypertension.

Results

Fourteen studies were included in this meta-analysis, including 3344 cases and 3377 controls. The eNOS intron 4a/b locus was significantly associated with increased susceptibility to hypertension (including essential hypertension) in the overall population, according to dominant, allelic, homozygote, heterozygote, and regressive models, in the mixed population according to the regressive model, and in Caucasians according to the dominant, allelic, heterozygote, and regressive models. The eNOS intron 4a/b locus was also significantly associated with increased susceptibility to essential hypertension in the mixed population according to the heterozygote model.

Conclusion

eNOS intron 4a/b gene polymorphisms increase susceptibility to hypertension, including essential hypertension.
Management of pregnancy with diffuse cutaneous systemic sclerosis: a case report and literature review
Authors: Yang Lingyun , Sun Weiwei , Yao Qiang
Published: December 2021

Diffuse cutaneous systemic sclerosis may occur in women of childbearing age. Pregnancies in this population are associated with a markedly increased risk of adverse obstetric and maternal outcomes even before the onset of symptoms related to sclerosis. We report a case involving the management and outcome of pregnancy in a 30-year-old woman with diffuse cutaneous systemic sclerosis. The course of her pregnancy was good and was assisted by a group consultation including obstetricians and rheumatologists. Vaginal delivery was the patient’s preferred choice because she had irregular skin tightness in her lower abdominal skin. She underwent induction of labor and combined spinal-epidural analgesia, and successfully delivered. Importantly, these pregnancies need to be planned, where possible, to allow the opportunity to counsel women and their partners in advance and to decrease any risks. These pregnancies should be considered high risk, and they require close antenatal monitoring and good supervision from an expert multidisciplinary team experienced in high-risk pregnancies. The management of delivery for patients with cutaneous systemic sclerosis is challenging, and vaginal delivery with labor analgesia is an alternative option to cesarean section.
Effect of sequential eradication therapy on serum osteoprotegerin levels in patients with Helicobacter pylori infection and co-existing inflammatory bowel disease
Authors: Murad Hussam , Rafeeq Misbahuddin , Mosli Mahmoud , Gari Mamdouh , Basheikh Mohammed
Published: December 2021

Objective

To investigate the effect of sequential Helicobacter pylori eradication therapy on serum osteoprotegerin levels in patients with H. pylori infection and co-existing inflammatory bowel disease (IBD).

Methods

Three groups of patients were involved in this observational cross-sectional study: IBD (n = 83), H. pylori infection (HP, n = 68), and H. pylori infection with co-existing IBD (HP + IBD, n = 52). These groups were compared with a normal control group (NC, n = 50). Serum osteoprotegerin, serum bone alkaline phosphatase (BALP), and fecal calprotectin (FC) levels were measured.

Results

Serum osteoprotegerin levels were significantly correlated with the simple endoscopic score for Crohn’s disease and Mayo score for ulcerative colitis. The receiver operating characteristic analysis of osteoprotegerin revealed high values for the area under the curve, sensitivity, and specificity. Discriminant analysis illustrated that osteoprotegerin levels significantly differentiated patients with IBD from healthy controls. Osteoprotegerin and FC levels distinguished the IBD and HP + IBD groups from the NC and HP groups.

Conclusions

Sequential eradication therapy did not affect serum osteoprotegerin levels in patients with H. pylori infection and co-existing IBD. Serum osteoprotegerin elevation might be a marker for IBD development in patients with past or current H. pylori infection.
Stereotypes About Battered Women and Victim’s Self-Defense: Legal Implications
Authors: Delgado-Alvarez Carmen , Sanchez-Prada Andrés
Published: December 2021

Recent research on the practices of justice operators with women victims of intimate partner violence has evidenced the existence of gender stereotypes and gender-blind practices in the Spanish legal system (Albertín et al., 2020; García Jiménez et al., 2019, 2020), as well as the graves consequences that such practices imply for these women. In this context, the present study explored the existence of a battered woman stereotype and its variation when the victim defends herself from the abuser. An opportunity sample of 505 undergraduates of Law, Psychology and other studies from two Spanish universities assessed some personality characteristics of a woman after watching a 1-minute-long silent video. The participants were randomly assigned to one of three observation conditions (“control”, “victim” or “self-defense victim”), which differed in the previous information given about the target woman. The Principal Components Analysis reduced the information from the questionnaire to three dimensions: “brittleness” (α = .91), “positive” (α = .786), and “hostile” (α = .809). The MANOVA confirmed the battered woman stereotype and its modification when the victim reacts against the abuser in self-defense: in this case the attribution of brittleness decreases and the attribution of hostility increases. The type of academic training showed significant effects on the stereotype, this being more negative among Law students than among Psychology ones. Law students perceive the target woman in the “victim” condition more hostile and manipulator. As for the “self-defense” condition, Law students attribute less brittleness to the victim, and perceive her more manipulator and dangerous. The effect of the observer's gender on the stereotype is consistent with the previous literature. Implications for professional training and judicial practices are discussed.
An exploration of patient satisfaction with and experience of a sexual abuse survivors clinic
Authors: Birdi Gurkiran , Caswell Rachel J , Ross Jonathan DC , Pattison Helen , Ayinde Oluseyi , Lorimer Karen
Published: December 2021

Background

The scale and extent of sexual violence perpetrated in the United Kingdom is being increasingly acknowledged. Support after the initial disclosure is often sought in NHS sexual health clinics. The purpose of this service evaluation was to explore patient satisfaction and experience amongst sexual health clinic attendees who disclosed sexual violence and were subsequently managed in a specialist sexual abuse survivors clinic.

Methods

Semi-structured interviews were conducted with ten service users and interview transcripts were analysed using interpretative phenomenological analysis (IPA) to assess users’ experiences within the clinic.

Results

Participants were all female (aged 18–54 years) and had experienced sexual violence between 2 weeks and 15 years prior to interview, and the majority self-identified as White British (6/10). IPA analysis revealed three distinct overarching themes which were important to this group of patients when evaluating their care: delivery of care in the context of judgement and stigma, aspects of care identified as healing or harmful to recovery, and the importance of the processes of providing care.

Conclusion

Understanding the experiences of sexual violence survivors in healthcare settings can optimise the provision of patient-oriented care and support. This includes ensuring the service user is in control of the consultation, the risks of re-traumatisation are minimised, and individuals receive relevant and accurate information but in a manageable volume and format.
Biased perceptions against female scientists affect intentions to get vaccinated for COVID-19
Authors: Doğan İsminaz , Baruh Lemi , Cemalcilar Zeynep , Kuru Ozan , Yıldırım Kerem , Çarkoğlu Ali
Published: December 2021

Based on role congruity theory, we investigated how gender bias may influence public attitudes toward the vaccine in Turkey. Using a between-subjects design, we tested whether an emphasis on the female versus the male scientist as the vaccine’s inventor in a news story influenced attitudes about the BioNTech vaccine and vaccination intentions. Partly confirming role congruity theory, three-way interaction results from 665 participants demonstrated that among male participants with a stronger belief in traditional gender roles (compared to males with lower belief), the presence of the female inventor, either by herself or together with the male inventor, decreased the perceived efficacy and safety of the vaccine and reduced intentions to be vaccinated by the BioNTech vaccine. We did not observe such differences for women. These findings highlight how gender bias may influence individuals’ information processing and decision making in a way that may have negative consequences for public health.
Cost-effectiveness analysis of acupuncture compared with usual care for acute non-specific low back pain: secondary analysis of a randomised controlled trial
Authors: Skonnord Trygve , Fetveit Arne , Skjeie Holgeir , Brekke Mette , Grotle Margreth , Klovning Atle , Aas Eline
Published: December 2021

Objective:

To assess the cost-effectiveness of a single treatment session of acupuncture, when applied in addition to usual care for acute low back pain (ALBP).

Methods:

Secondary analysis of a multicentre randomised controlled trial in Norwegian general practice. In total, 171 participants with ALBP ⩽14 days were randomised to a control group (CG) receiving usual care or to an acupuncture group (AG) receiving one additional session of Western medical acupuncture alongside usual care. Primary outcome measures for this cost-effectiveness analysis were quality-adjusted life years (QALYs), health care costs and societal costs at days 28 and 365, the incremental cost-effectiveness ratio (ICER) and net monetary benefit (NMB). The NMB was calculated on the basis of the Norwegian cost-effectiveness threshold of NOK 275,000 (USD 35,628) per QALY gained. Missing data were replaced by multiple chained imputation.

Results:

Eighty-six participants in the CG and 81 in the AG were included in the analysis. We found no QALY gain at day 28. At day 365, the incremental QALY of 0.035 was statistically significant. The differences in health care costs and societal costs were not statistically significant. Three out of four calculations led to negative ICERs (cost saving) and positive NMBs. For the health care perspective at day 365, the ICER was USD –568 per QALY and the NMB was USD 1265, with 95.9% probability of acupuncture being cost-effective.

Conclusion:

To our knowledge, this is the first cost-effectiveness analysis of acupuncture for ALBP. The findings indicate that acupuncture may be cost-effective from a 1-year perspective, but more studies are needed.

Trial registration number:

NCT01439412 (ClinicalTrials.gov).
All-cause mortality as the primary endpoint for the GRAIL/National Health Service England multi-cancer screening trial
Authors: Carr David , Kent David M. , Welch H. Gilbert
Published: December 2021

A randomized trial of the GRAIL GalleriTM multi-cancer screening test is being planned for the National Health Service in England, and will have 140,000 healthy participants aged 50–79: 70,000 exposed to screening and 70,000 unexposed. The test reportedly detects 50 different cancers and is expected to reduce all-cancer mortality by approximately 25%. Given this effect size—and that cancer deaths constitute a large fraction of all deaths—the trial is sufficiently large to test the effect on all-cause mortality. Because most patients believe cancer screening “saves lives”, the GRAIL/National Health Service collaboration could set the evaluation standard for multi-cancer screening.
Depicting the Prototype Change in Rural Consumer Behaviour: An Empirical Survey on Online Purchase Intention
Authors: Ghosal Indrajit , Prasad Bikram , Behera Mukti Prakash , Kumar Atul
Published: December 2021

E-commerce is an undeniable growth opportunity. The infrastructure of e-commerce has been successful in making their system resilience in this age of VUCA (volatility, uncertainty, complexity and ambiguity). Besides during the time of pandemic, e-commerce have accomplished in meeting the demand of the consumers crossing various obstacles and scarcity of resource across the colours of socio-economic stratification of India. A detailed investigation of social, cultural, behavioural norms along with effect of socio-cultural regions has been investigated to strengthen the research. The method of cluster analysis has been used to segment the consumers into homogeneous subsets. The implied findings of this research will help the digital entrepreneurs to know their target consumers. Through cluster analysis, six clusters have been identified and they are named as, (a) Advanced changers; (b) Price sensitive; (c) Enthusiasts; (d) Realistic and logical; (e) Conservatives; (f) Unconcerned. The outcomes of this research can help the strategy managers and intrapreneurs to make informed decisions. This study can be of value addition for startups, digital entrepreneurs to start their own business through online shopping portals. The extracted results can help the marketing managers to know about the specific attributes of the consumers of rural areas which will lead to framing strategy according to market design, market space and marketplace.
Pandering Politicians? Targeted Economic Development Incentives and Voter Response
Authors: Bundrick Jacob , Smith Erica , Yuan Weici
Published: December 2021

Empirical evidence largely suggests that the billions of dollars state and local governments spend on targeted economic development incentive (EDI) programs are typically ineffective at stimulating broad economic activity. The continued use of EDIs by public officials has thus led scholars to investigate the role of these programs in political pandering. In this paper, we explore the relationship between EDIs and gubernatorial elections in Arkansas. Specifically, we investigate whether officials strategically allocate discretionary EDIs based on previous county-level gubernatorial election outcomes. We subsequently explore the impact of discretionary EDIs on an incumbent party’s bid for gubernatorial reelection at the county level. Our results largely suggest that public officials do not allocate EDIs based on previous election outcomes. Moreover, our results indicate that voters are unresponsive to both the quantity and magnitude of credit claiming messages.
Inter-eye comparison of retinal vascular growth rate and angiographic findings following unilateral bevacizumab treatment
Authors: Bayramoglu Sadik Etka , Sayin Nihat
Published: December 2021

Purpose

To compare retinal vascularization progression rate, final retinal vascularization, and fluorescein angiography (FA) findings in infants who received intravitreal bevacizumab (IVB) treatment in one eye and with spontaneous regression in the other eye.

Methods

Thirty eyes of 15 infants who underwent IVB in one eye due to asymmetric retinopathy of prematurity, and who had pre-treatment fundus photographs and fluorescein angiography images were included in the study. Horizontal disc diameter (DD), optic disc-to-fovea distance (FD), and the length of temporal retinal vascularization (LTRV) distance were measured by evaluating pre-treatment and FA images.

Results

The mean ages at the time of treatment and FA were 40.38  ±  3.35 and 68.72  ±  10.52 weeks postmenstrual age, respectively. The pre-treatment LTRV/FD ratio was 3.11  ±  0.41 in the treated eyes and 3.26  ±  0.43 in the non-treated eyes (p  =  0.053). The final LTRV/FD ratio was 4.23  ±  0.38 in the treated group and 4.33  ±  0.37 in the non-treated group (p  =  0.286). Staining of the vessels, hyperfluorescent focus, and irregular branching of the vessels were similar between the groups, respectively (p  =  1.000; p  =  0.250; p  =  0.625).

Conclusion

The progression rate of retinal vascularization and angiographic findings were similar between the treated eyes and the non-treated eyes. Our study suggests that incomplete retinal vascularization in eyes treated with anti-vascular endothelial growth factor (VEGF) is due to the nature of the disease, and anti-VEGF treatment was not to cause cessation in vascular progression.
Body image(s): Problematizing future physical education teachers’ beliefs about the body and physical activity through visual imagery
Authors: González-Calvo Gustavo , Gallego-Lema Vanesa , Gerdin Göran , Bores-García Daniel
Published: December 2021

Visual culture affects the way people understand the world and themselves, contributing to the creation of certain roles and stereotypes, some of which are related to body image. This study focused on interrogating future physical education teachers’ beliefs about the body and physical activity to understand the construction of bodily subjectivities and their perceptions of how these are influenced by visual (physical) culture. Data were collected through the use of visual methods consisting of photo-elicitation and individual interviews with 23 students from a Primary Education Degree with a specialization in physical education at a Spanish university. Data were analyzed using thematic content analysis. The results of the study show that these future physical education teachers are aware of both the great influence of gender stereotypes and the values of consumerism in the field of physical activity stemming largely from the media, which inevitably will shape their future professional practice. However, the results also highlight how these future physical education teachers consider and position the subject of physical education as an important space where they could help students problematize and challenge these beliefs. We suggest that a focus on visual (physical) literacy is needed for future physical education teachers (and their students) to understand the world from a socially critical perspective and transform it in the interest of equity and social justice.
IGF-1 is not related to long-term outcome in hyperglycemic acute coronary syndrome patients
Authors: Iswandi Cindya P , van den Berg Victor J , Simsek Suat , Velzen Daan van , Boekel Edwin Ten , Cornel Jan-Hein , Boer Sanneke de , Mulder Maarten de , Akkerhuis K Martijn , Boersma Eric , Umans Victor A , Kardys Isabella
Published: December 2021

Purpose

Insulin-like growth factor-1 (IGF-1) has been associated with both protective and detrimental effects on the development of ischemic heart disease. The relationship between IGF-1 levels and major adverse cardiovascular events (MACE) in acute coronary syndrome (ACS) patients remains unclear. This study aimed to investigate the relationship between IGF-1 admission levels in hyperglycemic ACS patients and: (1) MACE over a 5 years follow-up, (2) type 2 diabetes at discharge, and (3) post-ACS myocardial infarct size and dysfunction.

Methods

This was a post hoc analysis of the BIOMArCS-2 randomized controlled trial. From July 2008 to February 2012, 276 ACS patients with admission plasma glucose level between 140 and 288 mg/dL were included. Records of the composite of all-cause mortality and recurrent non-fatal myocardial infarction were obtained during 5 years follow-up. Venous blood samples were collected on admission. IGF-1 was measured batchwise after study completion. Oral glucose tolerance test was performed to diagnose type 2 diabetes, whereas infarct size and left ventricular function were assessed by myocardial perfusion scintigraphy (MPS) imaging, 6 weeks post-ACS.

Results

Cumulative incidence of MACE was 24% at 5 years follow-up. IGF-1 was not independently associated with MACE (HR:1.00 (95%CI:0.99–1.00), p = 0.29). Seventy-eight patients (28%) had type 2 diabetes at discharge, and the highest quartile of IGF-1 levels was associated with the lowest incidence of diabetes (HR:0.40 (95%CI:0.17–0.95), p = 0.037). IGF-1 levels were not associated with post-ACS myocardial infarct size and dysfunction.

Conclusions

IGF-1 carries potential for predicting type 2 diabetes, rather than long-term cardiovascular outcomes and post-ACS myocardial infarct size and dysfunction, in hyperglycemic ACS patients.
“If Someone Has It, I’m Gonna Hit It”: Lessons Learned From Minnesota Teens About Vaping
Authors: Less Elyse Levine , Mady Melissa , Beckman Kara J. , Kingsbury John H.
Published: December 2021

Youth e-cigarette use or “vaping” has increased substantially in the past few years, an escalation attributable to flavored “pod mod” e-cigarette devices that deliver higher levels of nicotine compared with free-base nicotine found in other types of e-cigarettes. Use rates, addiction, and harms are alarming as negative effects from nicotine on adolescent brain development are well documented, and e-cigarette use is predictive of cigarette smoking initiation. This qualitative study examined what drives the appeal of these products through 10 focus groups conducted in 2019 with 67 Minnesota high school students. Focus groups aimed to understand students’ personal experiences and contextual factors that may contribute to current vaping trends and explore opportunities for improved prevention messaging. Study results revealed participants’ divergent perceptions of tobacco products (i.e., vaping vs. e-cigarettes vs. cigarettes) and the benefits and harms of each product. Participants provided insights into why youth vape, describing vaping as an easily accessible coping method to help teens manage stress and anxiety. Peer normalization and invincibility beliefs about harms were also present. Participants generated ideas about prevention messaging, describing the ineffectiveness of prevention messages they currently receive, and expressing the need for accurate information about e-cigarette health risks presented in personalized, nonjudgmental contexts by people they know care about them. These results have clear implications for prevention initiatives and can be used to inform effective prevention strategies, messaging, programming, and policies, some of which are specific to e-cigarette prevention and others that align with the theory of positive youth development.
Aberrant Alteration of Circulating Lymphocyte Subsets in Small Cell Lung Cancer Patients Treated with Radiotherapy
Authors: Li Hui , Yu Hong , Lan Shaowei , Zhao Dandan , Liu Yan , Cheng Ying
Published: December 2021

Purpose: The role of different circulating lymphocyte subsets, as well as their correlation with clinical characteristics of small cell lung cancer patients have not yet been fully understood. This study aims to evaluate the influence of the fluctuating absolute numbers of lymphocyte subpopulations in peripheral blood of patients with small cell lung cancer. Methods: The absolute counts and percentages of lymphocyte subsets in peripheral blood of 329 patients with small cell lung cancer were retrospectively analyzed. The numbers of CD3+, CD3+CD4+, and CD3+CD8+ T lymphocytes, CD3−CD19+ B lymphocytes, and CD3−CD16+CD56+ NK cells were evaluated by flow cytometry. Their relationship with the patients’ clinical characteristics were statistically evaluated. Results: The CD4/CD8 values derived from the absolute number and percentage of CD3+CD4+ cells divided by CD3+CD8+ cells were identical (1.86  ±  0.99). There was no association between any of the lymphocyte subsets levels and age/sex of the 329 patients with small cell lung cancer. The patients with advanced stage had a reduction in CD3+ and CD3+CD4+ T cell counts and a decreased CD4/CD8 ratio. The levels of CD3+CD4+ T cells, CD3−CD19+ B cells, CD3−CD16+CD56+ NK cells, and CD4/CD8 ratio were associated with advanced tumor-node-metastasis stage. Patients who had undergone radiotherapy were characterized by lymphopenia with lower numbers of CD3+, CD3+CD4+, CD3+CD8+ T lymphocyte, B lymphocyte, NK cell, and CD4/CD8 ratio. The evaluation of individual CD4/CD8 ratio should be combined with other clinical parameters. Conclusions: Patients with small cell lung cancer have altered lymphocyte homeostasis. Lymphopenia was a long-lasting feature of the enrolled patients who were treated with radiotherapy. The available lymphocyte subsets levels might be used to manage the clinical treatment scheme.
Engaging African American Pastors in COVID-19 Research During a Pandemic: Lessons Learned
Authors: Hayes Traci , Baskin LaWanda , Funchess Tanya , Lowe Samaria , Mayfield-Johnson Susan
Published: December 2021

African American pastors are recognized as trusted information sources for their communities. The pastors willing to address health-related concerns such as preventing the spread of the coronavirus are invaluable for leading their congregation through relevant health programs. Underlining the importance of religion, spirituality, and faith-based leaders in addressing and furthering health promotion research, the article discusses lessons learned during the study implementation and the recommendations for engaging minority pastors in research during a global health pandemic.
No significant difference in risk of prolonged opioid use following outpatient versus inpatient total shoulder arthroplasty: A propensity matched analysis
Authors: Xiao Michelle , Curtis Daniel M , Cheung Emilie V , Freehill Michael T , Abrams Geoffrey D
Published: December 2021

Background

The purpose of this investigation was to compare rates of filled opioid prescriptions and prolonged opioid use in opioid naïve patients undergoing total shoulder arthroplasty (TSA) in inpatient versus outpatient settings.

Methods

A retrospective cohort study was conducted using a national insurance claims database. Inpatient and outpatient cohorts were created by identifying continuously enrolled, opioid naïve TSA patients. A greedy nearest-neighbor algorithm was used to match baseline demographic characteristics between cohorts with a 1:1 inpatient to outpatient ratio to compare the primary outcomes of filled opioid prescriptions and prolonged opioid use following surgery between cohorts.

Results

A total of 11,703 opioid naïve patients (mean age 72.5 ± 8.5 years, 54.5% female, 87.6% inpatient) were included for analysis. After propensity score matching (n = 1447 inpatients; n = 1447 outpatients), outpatient TSA patients were significantly more likely to fill an opioid prescription in the perioperative window compared to inpatients (82.9% versus 71.5%, p < 0.001). No significant differences in prolonged opioid use were detected (5.74% inpatient versus 6.77% outpatient; p = 0.25).

Conclusions

Outpatient TSA patients were more likely to fill opioid prescriptions compared to inpatient TSA patients. The quantity of opioids prescribed and rates of prolonged opioid use were similar between the cohorts.

Level of evidence

Therapeutic Level III.
Reported Outcomes and Outcome Measures in Proximal Interphalangeal Joint Arthroplasty: A Systematic Review
Authors: Uhlman Kathryn , Abdel Khalik Hassaan , Murphy Jessica , Karpinski Marta , Thoma Achilles
Published: December 2021

Purpose: There is a lack of scientific consensus on the best arthroplasty implant option for proximal interphalangeal joint (PIPJ) arthritis, due to diversity in outcome reporting and measurement methods. The development of a standardized core outcome set (COS) and standard outcome measures could mitigate this issue. This study catalogs the reported outcomes and outcome measures found in PIPJ arthroplasty studies, which can be used in the first step of developing a COS. Methods: A database search of MEDLINE, EMBASE, and Web of Science (January 1, 2010, to March 10, 2021) was performed to retrieve studies that reported outcomes of the 3 most common primary PIPJ arthroplasty implants: silicone, pyrocarbon, and metal-polyethylene. The primary objectives of this study include reported outcomes and outcome measures. Secondary objectives include clinimetric properties of outcome measures, study design, and implant types. Results: Fifty articles met inclusion criteria. Of the included studies, 41 (82%) were case series, 8 (16%) were cohort studies, and 1 (2%) was a randomized control trial. Thirty-three unique outcomes were identified. Fifteen (46%) outcomes were clinician-reported and 26 (79%) were patient-reported. Eighteen unique outcome measures were identified. Of the outcome measures, 15 (83%) were patient-reported, 1 (6%) was clinician-reported, and 2 (11%) were reported by both patients and clinicians. Conclusions: Substantial heterogeneity was found in reported outcomes and outcome measures across studies evaluating PIPJ arthroplasty, impeding knowledge translation. The development of a COS for PIPJ arthroplasty is necessary to help compare and pool data across studies, and advance scientific knowledge.
Using environmental DNA methods to improve detectability in an endangered sturgeon (Acipenser sinensis) monitoring program
Authors: Yu Dan , Shen Zhongyuan , Chang Tao , Li Sha , Liu Huanzhang
Published: December 2021

Background

To determine the presence and abundance of an aquatic species in large waterbodies, especially when populations are at low densities, is highly challenging for conservation biologists. Environmental DNA (eDNA) has the potential to offer a noninvasive and cost-effective method to complement traditional population monitoring, however, eDNA has not been extensively applied to study large migratory species. Chinese sturgeon (Acipenser sinensis), is the largest anadromous migratory fish in the Yangtze River, China, and in recent years its population has dramatically declined and spawning has failed, bringing this species to the brink of extinction. In this study, we aim to test the detectability of eDNA methods to determine the presence and relative abundance of reproductive stock of the species and whether eDNA can be used as a tool to reflect behavioral patterns. Chinese sturgeon eDNA was collected from four sites along the spawning ground across an eight month period, to investigate the temporal and spatial distribution using droplet digital PCR (ddPCR).

Results

We designed a pair of specific primers for Chinese sturgeon and demonstrated the high sensitivity of ddPCR to detect and quantify the Chinese sturgeon eDNA concentration with the limit of detection 0.17 copies/μl, with Chinese sturgeon eDNA been intermittently detected at all sampling sites. There was a consistent temporal pattern among four of the sampling sites that could reflect the movement characteristics of the Chinese sturgeon in the spawning ground, but without a spatial pattern. The eDNA concentration declined by approximately 2–3 × between December 2018 and December 2019.

Conclusions

The results prove the efficacy of eDNA for monitoring reproductive stock of the Chinese sturgeon and the e decreased eDNA concentration reflect that Chinese sturgeon may survive with an extremely small number of reproductive stock in the Yangtze River. Accordingly, we suggest future conservation measures should focus on both habitat restoration and matured fish restocking to ensure successful spawning. Overall, this study provides encouraging support for the application of eDNA methods to monitor endangered aquatic species.
Analysis of CcGASA family members in Citrus clementina (Hort. ex Tan.) by a genome-wide approach
Authors: Wu Tianli , Zhong Yun , Chen Min , Wu Bo , Wang Ting , Jiang Bo , Zhong Guangyan
Published: December 2021

The Gibberellic Acid Stimulated Arabidopsis (GASA) proteins were investigated in the study to help understand their possible roles in fruit trees, particularly inCitrus. A total of 18 CcGASA proteins were identified and characterized inCitrus clementinavia a genome-wide approach. It was shown that the CcGASA proteins structurally shared a conserved GASA domain but varied considerably in primary sequences and motif compositions. Thus, they could be classified into three major phylogenetic groups, G1~G3, and two groups, G1 and G3 could be further classified into subgroups. The cis- elements on allCcGASApromoters were identified and categorized, and the associated transcription factors were predicted. In addition, the possible interactions between the CcGASA proteins and other proteins were predicted. All the clues suggested that these genes should be involved in defense against biotic and abiotic stresses and in growth and development. The notion was further supported by gene expression analysis that showed these genes were more or less responsive to the treatments of plant hormones (GA3, SA, ABA and IAA), and infections of citrus canker pathogenXanthomonas citri.It was noted that both the segmental and the tandem duplications had played a role in the expansion of theCcGASAgene family inCitrus.Our results showed that the members of theCcGASAgene family should have structurally and functionally diverged to different degrees, and hence, the representative group members should be individually investigated to dissect their specific roles.