bluuebunny/crossref_metadata_2025 huggingface dataset:
Emilio PERAL VEGA.— “La verdad ignorada”. Homoerotismo masculino y literatura en España (1890-1936). Madrid: Cátedra, 2021, 291 pp.
Authors: De la Torre-Espinosa Mario
Published: January 2023

Reseña
EL CUERPO SIGNIFICANTE: SEMIÓTICA DE LA CORPORALIDAD
Authors: Lacalle Zalduendo Charo , De la Torre-Espinosa Mario
Published: January 2023

En este número monográfico se recogen siete contribuciones que abordan la intersección de la semiótica con las ciencias cognitivas, la lectura del cuerpo de C.S. Peirce, la impronta del cuerpo en la construcción del género, tanto en su ámbito físico como en el digital, y la corporalidad como elemento constitutivo del teatro. Vienen a constituirse en muestra de la aplicabilidad de la semiótica a diversos ámbitos de la contemporaneidad, al mismo tiempo que se efectúan algunas calas en cuestiones teóricas que vienen a demostrar la operatividad de esta disciplina en pleno siglo XXI.
SEMIÓTICA AUDIOVISUAL Y NEUROCIENCIA COGNITIVA. EL PROYECTO DE LA NEUROFILMOLOGÍA Y LA CUESTIÓN DE LA EXPERIENCIA TEMPORAL
Authors: Eugeni Ruggero
Published: January 2023

Este artículo presenta un marco de investigación basado en el diálogo entre semiótica audiovisual y ciencias neurocognitivas llamado Neurofilmología que actualiza la semiótica interpretativa y que busca esbozar un modelo de la experiencia de visionado que tenga en cuenta la relación encarnada entre un organismo-espectador y su entorno. Este modelo se elabora a nivel metaempírico, reuniendo resultados empíricos de análisis semióticos y experimentos neuropsicológicos. En particular, el artículo ilustra la metodología y resultados de una investigación neuropsicológica en curso sobre la experiencia temporal en el visionado de productos audiovisuales. La experiencia del tiempo no depende de un abstracto reloj interno, sino que está vinculada a una serie de movimientos realizados o percibidos por el sujeto. Este fenómeno se intensifica durante el visionado, en comparación con la experiencia ordinaria. Esta visión encarnada explica las particularidades de la experiencia temporal del espectador y hace del cine un laboratorio de la temporalidad único.
TRAMPAS DEL BINARISMO: DICOTOMÍAS DE GÉNERO Y SISTEMA PUBLICITARIO (UN CASO PRÁCTICO DURANTE LA CRISIS DE LA COVID-19)
Authors: Bernárdez-Rodal Asunción , Moreno-Segarra Ignacio
Published: January 2023

Este estudio analiza la construcción socio-semiótica del género en dos anuncios de la aseguradora Mapfre que estuvieron protagonizados por dos deportistas de élite como son Fernando Alonso y María Vicente y que tuvieron una enorme repercusión online durante 2021. Estos dos anuncios presentan narrativas de recuperación y superación que están construidas sobre una visión dicotómica de las expresiones de género y en torno a una serie de conceptos contrapuestos. A través de las herramientas de la semiótica verbovisual y la teoría estructuralista analizamos la lectura de género y el uso simbólico de conceptos binarios como exterior/interior, vertical/horizontal o razón/pasión que configuran un relato sobre la independencia y la dependencia que está profundamente ligado con la crisis sanitaria de la COVID-19. El análisis demuestra que, pese a los intentos de desmontaje posmodernos, los binarismos de género continúan siendo narrativas tranquilizadoras que aparecen reforzadas por mecanismos publicitarios regidos por algoritmos o por situaciones excepcionales como crisis sanitarias.
CUANDO LAS MUJERES TOMARON EL PINCEL. LECTORAS, EDITORAS Y AUTORAS EN LA CHINA PRE-MODERNA
Authors: Relinque Eleta Alicia
Published: January 2023

En China, desde la dinastía Han (202 a.C.-220 d.C.) la escritura se constituirá en una clave de acceso al poder. Este acceso prácticamente estará restringido a los hombres que, en muchas ocasiones, adoptarán una voz poética femenina. El artículo presenta una revisión sobre algunos aspectos de esta usurpación de la voz femenina, mencionando la aparición de algunas escritoras a lo largo de la historia hasta el advenimiento de la dinastía Ming (1387-1644). Mostraremos cómo el discurso filosófico de esta época en torno a la pasión (qing) se plasma en El Pabellón de las Peonías, del dramaturgo Tang Xianzu (1550-1616). La obra, con una protagonista femenina, tendrá como consecuencia directa, junto a otros factores, la aparición en los siglos XVII y XVIII de un gran número de mujeres lectoras, editoras o autoras, de las que presentamos algunos de sus textos más representativos.
LA NOVELA DE LA ARTISTA Y EL RECUERDO: LOS CASOS DE ARTEMISIA DE ANNA BANTI, EL CUADERNO DORADO DE DORIS LESSING Y ORACIONES EN ESPIRAL DE DANIELA HODROVÁ
Authors: Peña-Molina María del Pilar
Published: January 2023

Este artículo estudia la consideración de la obra de arte como forma de rescate. Para ello, estudia el papel del recuerdo en la novela de la artista, protagonizada por la mujer artista y escrita también por mujeres, en este caso, desde el enfoque aportado por los estudios del trauma. Se han tomado tres casos de estudio de la narrativa contemporánea pertenecientes a tres tradiciones distintas: literatura italiana, inglesa y checa. En primer lugar, el artículo realiza un estudio de la novela como reescritura de la historia. En segundo lugar, analiza el papel que tiene el recuerdo en la novela de la artista. Todo esto, junto con el enfoque otorgado por los estudios del trauma, permite vincular la obra de arte con la sanación del trauma.
Role of radiofrequency ablation in advanced malignant hilar biliary obstruction
Authors: Takenaka Mamoru , Lee Tae Hoon
Published: January 2023

Malignant hilar biliary obstruction (MHO), an aggressive perihilar biliary obstruction caused by cholangiocarcinoma, gallbladder cancer, or other metastatic malignancies, has a poor prognosis. Surgical resection is the only curative treatment for biliary malignancies. However, the majority of patients with MHO cannot undergo surgery on presentation because of an advanced inoperable state or a poor performance state due to old age or comorbid diseases. Therefore, palliative biliary drainage is mandatory to improve symptomatic jaundice and the quality of life. Among the drainage methods, endoscopic biliary drainage is the current standard for palliation of unresectable advanced MHO. In addition, combined with endoscopic drainage, additional local ablation therapies, such as photodynamic therapy or radiofrequency ablation (RFA), have been introduced to prolong stent patency and survival. Currently, RFA is commonly used as palliative therapy, even for advanced MHO. This literature review summarizes recent studies on RFA for advanced MHO.
Playing at Being a Superhero
Authors: Green Stephanie
Published: January 2023

Abstract

The superhero fantasy Jessica Jones completed its third and final season having offering a sustained exploration of (dis)ability, social responsibility and the female superhero. In this essay, I examine the tensions between play and responsibility in relation to the character of Trish Walker, Jessica Jones’s adoptive sister and friend. I draw from Giorgio Agamben’s notion of ‘play’ and ideas from cognitive psychology such as ‘flow’ (Csikszentmihalyi 2014) and ‘dark play’ (Linderoth and Mortensen 2015), to consider how the series positions the two women, awkwardly but interestingly, in terms of gender and justice.

Trish Walker’s ambition is to be a superhero like Jessica and she eventually attains this, first through the use of chemical enhancement, in Season One. In the episode At the end of Season Two, Trish gains enduring physical powers of agility and strength through a medical experiment, improving her new abilities through intensive physical practice, and sets out to become a vigilante, like Hellcat in the original comic (Marvel 1944/1976). She begins spending her time on the streets with the intention of fighting crime, but, after her mother is murdered in Season Three, she sets out on a path of punishment and revenge without ethical restraint.

Can Trish’s transformation be seen as a form of ‘play’ – at attempt to express the sense of selfhood that has been subsumed under her mother’s needs? Is her determination to become ‘super’ a way to break-out from her famous persona as the cute little girl of a television show? Is it instance of flow – the directed use of attention to gain advantage? (Csikszentmihalyi 2014) Can it be seen as a form of ‘dark play’ (Linderoth and Mortensen 2015) in which the audience, along with the character of Trish, is invited to see what happens and how it feels to take revenge? Is it a negative compulsion in which self-determined autonomy and social responsibility are undermined by the imperative to act at all costs? Or, has Trish been framed, to some extent, by the limited scope available for female characters in action combat roles?
Be Gay Do Crime
Authors: Austin Isobella
Published: January 2023

This essay deals with queer theory and how it applies to the videogame Cloudpunk and the comic series Motor Crush. Both of these texts use cyberpunk settings to tell stories about finding hope in community. Each text features protagonists trying to navigate worlds where legal success is highly competitive and practically impossible. They must therefore turn to community building, mutual aid, and criminal activity to find happiness. This analysis views the texts through the lens of queer time and queer space making practices as outlined by J Jack Halberstam and Jose Esteban Muñoz. Central to this article’s exploration of these texts is the characters inability and/or refusal to fit neatly into the worlds they inhabit, and how they must therefore find success outside of accepted channels. Success is only found by these characters through an attitude that can be summarised by the queer anarchist meme “be gay, do crime”, which connotes a sense of mischief, solidarity, and standing up to authority. The rigid social hierarchies that are built into the dystopian worlds is reflected in the infrastructure of the cities, which do not account for anyone living outside of an accepted norm. It is therefore considered an act of radical solidarity to break the rules if it is in support of others.
Ribes middelalderlige gadebelægninger
Authors: Knudsen Maria
Published: January 2023

Som en del af den løbende renovering af gaderne i Ribes middelalderlige bykerne kom turen i foråret 2017 til Sviegade.Sydvestjyske Museer fulgte med. Undersøgelsens resultater har klargjort Sviegades rolle i Ribes middelalderlige gadenet
Broen til Fanø
Authors: Zeeberg Nils Kristian
Published: January 2023

Anmeldelse af artikel i Sjæklen: Jørgen Burchardt: Broen til Fanø - 100 års mislykkede planer.
Danmarks første lærebog i vejbygning var tysk
Authors: Zeeberg Nils Kristian
Published: January 2023

Veiledning til Hoved- og mindre Landeveies Bygning og Vedligeholdelse, af Heinrich Friherre v. Pechmann, blev udgivet i Danmark i 1838 og blev et vigtigt læremiddel.
Wielkość dostawy wybranych zanieczyszczeń atmosferycznych i ich wpływ na jakość wód w zurbanizowanej zlewni Różanego Strumienia w Poznaniu w latach hydrologicznych 2016‑2020 = The level of supply of selected atmospheric pollutants and their impact on water quality in the urban catchment of Różany Strumień in Poznan, Poland, in hydrological years 2016‑2020
Authors: Major Maciej , Chudzińska Maria , Majewski Mikołaj
Published: January 2023

The main aim of the work detailed here was to identify the level and composition of selected atmospheric pollutants supplied mainly with precipitation to the urbanized Różany Strumień catchment in Poznań, Poland; and to determine their impact on the chemical composition of water at subsequent stages of its circulation. The research was conducted in the hydrological years 2016-2020 as part of the Integrated Monitoring of the Natural Environment in Poland (ZMŚP) program, using the infrastructure of the ZMŚP’s "Poznań-Morasko" Base Station – of Adam Mickiewicz University in Poznań – the first such Base Station to be located within the boundaries of a large urban agglomeration. A key finding concerned a positive ion balance among nutrients supplied as a result of human activity (e.g. through fertiliser use) – involving NO3-, NH4+ and K+. Remaining chemical components (denudation ions) present in the waters circulating in the catchment are in turn characterised by a negative balance.
Przywracanie ekosystemów leśnych – cele i założenia działań globalnych w kontekście Dekady Przywracania Ekosystemów (2021‑2030) ONZ = Forest ecosystem restoration – assumptions and aims of global activities in the context of the United Nations Decade of Ecosystem Restoration (2021‑2030)
Authors: Bożętka Barbara
Published: January 2023

The work attempts to identify aims and principles of the UN Decade on Ecosystem Restoration (2021-2030), in regard to the issues of forest degradation and protection. The procedure followed here assumed two chief directions as it analysed forest degradation (including deforestation) and investigated the theoretical bases underpinning the restoration of forest ecosystems. Also incorporated was a review of relevant global environmental policies, along with remarks as to what has been achieved in this field in practical terms. The study thus highlights key dimensions to the degradation of natural ecosystems, where these concern the counteraction of further deterioration of forests, given the aspects relating to policy on global biodiversity, the protection of land and climate protection. While ecological aspects of forest restoration are naturally a main focus, the spirit of the UN’s Decade has been borne in mind, with the socio-economic and cultural merits of activities undertaken also incorporated into the examination. The work thus demonstrates the main goals, strategies and directions where the restoration of forest ecosystems is concerned, also pointing out exemplary large-scale projects and initiatives. The research has also taken in what may be seen as a leading direction within forest restoration, i.e. Forest Landscape Restoration (FLR). The study likewise accentuates the importance of tropical forests in any global pro-ecological agenda, while also emphasising the requirement for a complex approach to be taken to ecosystem restoration, and for natural ecosystems to gain protection and be reinforced as regards their resilience.
Application of the Beneish Model on the Warsaw Stock Exchange
Authors:   University of Warsaw, Faculty of Economic Sciences Poland, Sylwestrzak Marek
Published: January 2023

This paper investigates irregularities in financial statements by applying the Beneish and Roxas models to Polish firms listed on the Warsaw Stock Exchange from 2015 to 2020. The total sample included 110 observations. The sample comprised companies that had received an adverse or disclaimer opinion by the auditors, but had not been fined by the Polish Financial Supervision Authority (KNF Board). The control firms were selected based on the industry as selected by the standard industrial classification code and on the financial year, with minimizing the difference in the size of total assets. The results indicate that the Roxas model revealed greater accuracy than the Beneish model on the tested sample. The use of logistic regression allowed a modification of the Beneish model to align it with the conditions of the Polish market. The modified Beneish model showed greater accuracy for the tested sample and companies fined by the KNF Board.
El enfoque en derechos humanos en los proyectos educativos de centro de Galicia
Authors: RODRÍGUEZ OTERO LUIS MANUEL , Gándara Galaviz Susana Dolores
Published: January 2023

Se abordó una investigación mixta con el objetivo de analizar la presencia del enfoque en Derechos Humanos (en adelante, DDHH) en los Proyectos Educativos de Centro de 116 Institutos de Educación Secundaria de Galicia, seleccionados a través de un muestreoestratificado. Se realizó un análisis descriptivo de las categorías axiales asociadas a cada uno de los descriptores de DDHH y de contenido de las referencias explícitas a los DDHH. Los resultados revelaron que los entornos rurales mencionan en mayor medida cada una de las dimensiones en sus proyectos que los centros urbanos. Asimismo, se advirtieron 34 referencias explícitas a los DDHH en 3 centros (2.58 %); las cuales aluden a todos los principios delplan de acción del programa mundial para la educación en DDHH, a excepción del desarrollo de capacidades en responsables educativos. Se considera necesario promover el enfoque en DDHH en el nivel de secundaria.
¡Las niñas ya no quieren ser princesas! La educación informal, la publicidad de juguetes y la construcción de los géneros en la infancia
Authors: Sáenz del Castillo Velasco Aritza , Arregi Orue Joseba Iñaki
Published: January 2023

En la sociedad de la información y de la comunicación, los media se han transformado en agentes socializadores por excelencia. Desde la alfabetización crítica, la presenteinvestigación tiene por objeto analizar la publicidad de juguetes impresa desde una perspectiva de género, ya que esta actúa como difusora de modelos sociales y culturales que lainfancia asume acríticamente y que pueden derivar en situaciones discriminatorias de desigualdadentre hombres y mujeres. Para el desarrollo de este estudio se tomó como fuente las imágenes presentes en los catálogos de juguetes de las principales casas comerciales, que fueron sometidas a un análisis de contenido a través de la interpretación documental de carácter gráfico. De este modo, se analizaron las siguientes categorías: protagonistas, tipologíade juguetes, espacios de representación y, funciones e interacciones sociales. Los resultadosobtenidos muestran un cambio respecto al protagonismo femenino, pues su presencia ha incrementado considerablemente. No obstante, la cosmovisión que transmiten evidenciaun patrón muy tradicional y una segregación de género muy marcada. Así, en las funciones sociales representadas en estos catálogos prima el modelo de feminidad asociado a la maternidad-domesticidad-belleza y el modelo de masculinidad vinculado a la figura de hombre ganador de pan (proveedor) –activo, fuerte, …–. A tenor de los resultados, se puede concluir que esta publicidad sigue alejada de los fines coeducativos y dificulta la consecución de una ciudadanía democrática e igualitaria.
Ecociudadanía y educación del consumo alimentario. Buenas prácticas socioeducativas en iniciativas ciudadanas de consumo responsable
Authors: Bisquert i Pérez Kylyan Marc , Meira Cartea Pablo Ángel , Agúndez Rodríguez Adolfo
Published: January 2023

El sistema agroalimentario industrial-globalizado constituye un factor crítico de la actual crisis socioambiental. Sus impactos contribuyen significativamente a superar los límites biofísicos del planeta y generan profundas brechas de desigualdad, mientras siguen sin alcanzarse los objetivos globales de seguridad alimentaria. En este marco, la construcción sociocultural de la dieta desempeña un papel fundamental en un sentido ambivalente: por un lado, puede favorecer la reproducción de dicho sistema; por el otro, puede impulsar alternativas configuradas bajo criterios de consumo responsable. De este modo, deviene en un elemento educativo de especial relevancia para promover la transición hacia sistemas agroalimentarios sostenibles. En este sentido, en el estudio que aquí se presenta se han explorado las buenas prácticas socioeducativas que desarrollan las iniciativas ciudadanas que disponen canales y espacios alternativos de consumo responsable de alimentos. Mediante un estudio de casos múltiple realizado en la provincia de A Coruña (Galicia) con la aplicación de 42 entrevistas semiestructuradas, se analizaron las características generales de dichas iniciativas, su organización y su dimensión socioeducativa. Así mismo, desde un enfoque ecociudadano de la educación del consumo y desde el marco de la cultura de la sostenibilidad, se valoraron las prácticas socioeducativas que las iniciativas analizadas desarrollan, identificando aquellas susceptibles de contribuir a construir un modelo de educación del consumo alimentario situado en las coordenadas de la educación ambiental. Por último, a partir del abanico de actividades que estas iniciativas presentan, se identificaron cuatro categorías que congregan al conjunto de buenas prácticas que constituyen valiosas fuentes de experiencia práctica para articular enfoques socioeducativos orientados a afrontar la crisis socioambiental desde el ámbito agroalimentario.
Accommodation Dispensing or Course Design Consulting?: Views and Experiences of Accessibility Consultants Contributing to Inclusive Course Redesigns in Postsecondary Education
Authors: Burge Philip , Mazzuca Josephine
Published: January 2023

There are growing demands to proactively support students with disabilities in postsecondary education. This article examines a mixed-methods study with accessibility consultants and other faculty in a community college pilot program focussed on redesigning courses to increase inclusiveness. Findings highlight the successful and well-received role of the accessibility consultants collaborating in redesign triads. Challenges experienced by accessibility consultants are also discussed, for example, around time allocation for this type of work along with their daily support of students. Recommendations for accessibility consultants involvement in expanding inclusive course redesigns are made, such as, including them more in the process of curriculum design and ensuring appropriate time for their participation.
Labirintos de Borges e Saramago: espaço, palavra e identidade
Authors: Sotta Cleomar Pinheiro
Published: January 2023

Este estudo crítico defende que é possível aproximar a produção narrativa de Jorge Luis Borges e José Saramago tendo como guia a imagem do labirinto, selecionando três grandes perspectivas em que ela se desdobra. A primeira delas é a espacial. Ambos os escritores tendem a descrever os ambientes por onde circulam os personagens, traçando uma analogia com as definições e características labirínticas acumuladas ao longo do tempo. Em segundo lugar está a evocação do labirinto na própria escrita, na forma de organizar os textos, na pontuação e, principalmente, no tom ensaístico-filosófico e nas notas digressivas intercaladas ao enredo. Por último, a busca pela identidade também se associa a vias labirínticas, na medida em que se compõe como um trajeto cheio de incertezas, objetivando chegar ao centro, isto é, ao encontro de um eu consigo mesmo e com um outro.
Nanobodies combined with DNA-PAINT super-resolution reveal a staggered titin nanoarchitecture in flight muscles
Authors: Schueder Florian , Mangeol Pierre , Chan Eunice HoYee , Rees Renate , Schünemann Jürgen , Jungmann Ralf , Görlich Dirk , Schnorrer Frank
Published: January 2023

Sarcomeres are the force-producing units of all striated muscles. Their nanoarchitecture critically depends on the large titin protein, which in vertebrates spans from the sarcomeric Z-disc to the M-band and hence links actin and myosin filaments stably together. This ensures sarcomeric integrity and determines the length of vertebrate sarcomeres. However, the instructive role of titins for sarcomeric architecture outside of vertebrates is not as well understood. Here, we used a series of nanobodies, the Drosophila titin nanobody toolbox, recognising specific domains of the two Drosophila titin homologs Sallimus and Projectin to determine their precise location in intact flight muscles. By combining nanobodies with DNA-PAINT super-resolution microscopy, we found that, similar to vertebrate titin, Sallimus bridges across the flight muscle I-band, whereas Projectin is located at the beginning of the A-band. Interestingly, the ends of both proteins overlap at the I-band/A-band border, revealing a staggered organisation of the two Drosophila titin homologs. This architecture may help to stably anchor Sallimus at the myosin filament and hence ensure efficient force transduction during flight.
Inhibition is a prevalent mode of activity in the neocortex around awake hippocampal ripples in mice
Authors: Karimi Abadchi Javad , Rezaei Zahra , Knöpfel Thomas , McNaughton Bruce L , Mohajerani Majid H
Published: January 2023

Coordinated peri-ripple activity in the hippocampal-neocortical network is essential for mnemonic information processing in the brain. Hippocampal ripples likely serve different functions in sleep and awake states. Thus, the corresponding neocortical activity patterns may differ in important ways. We addressed this possibility by conducting voltage and glutamate wide-field imaging of the neocortex with concurrent hippocampal electrophysiology in awake mice. Contrary to our previously published sleep results, deactivation and activation were dominant in post-ripple neocortical voltage and glutamate activity, respectively, especially in the agranular retrosplenial cortex (aRSC). Additionally, the spiking activity of aRSC neurons, estimated by two-photon calcium imaging, revealed the existence of two subpopulations of excitatory neurons with opposite peri-ripple modulation patterns: one increases and the other decreases firing rate. These differences in peri-ripple spatiotemporal patterns of neocortical activity in sleep versus awake states might underlie the reported differences in the function of sleep versus awake ripples.
A hierarchy of cell death pathways confers layered resistance to shigellosis in mice
Authors: Roncaioli Justin L , Babirye Janet Peace , Chavez Roberto A , Liu Fitty L , Turcotte Elizabeth A , Lee Angus Y , Lesser Cammie F , Vance Russell E
Published: January 2023

Bacteria of the genus Shigella cause shigellosis, a severe gastrointestinal disease driven by bacterial colonization of colonic intestinal epithelial cells. Vertebrates have evolved programmed cell death pathways that sense invasive enteric pathogens and eliminate their intracellular niche. Previously we reported that genetic removal of one such pathway, the NAIP–NLRC4 inflammasome, is sufficient to convert mice from resistant to susceptible to oral Shigella flexneri challenge (Mitchell et al., 2020). Here, we investigate the protective role of additional cell death pathways during oral mouse Shigella infection. We find that the Caspase-11 inflammasome, which senses Shigella LPS, restricts Shigella colonization of the intestinal epithelium in the absence of NAIP–NLRC4. However, this protection is limited when Shigella expresses OspC3, an effector that antagonizes Caspase-11 activity. TNFα, a cytokine that activates Caspase-8-dependent apoptosis, also provides potent protection from Shigella colonization of the intestinal epithelium when mice lack both NAIP–NLRC4 and Caspase-11. The combined genetic removal of Caspases-1, -11, and -8 renders mice hyper-susceptible to oral Shigella infection. Our findings uncover a layered hierarchy of cell death pathways that limit the ability of an invasive gastrointestinal pathogen to cause disease.
How the brain stays in sync with the real world
Authors: Koevoet Damian , Sahakian Andre , Chota Samson
Published: January 2023

The brain can predict the location of a moving object to compensate for the delays caused by the processing of neural signals.
High and low dose of luzindole or 4-phenyl-2-propionamidotetralin (4-P-PDOT) reverse bovine granulosa cell response to melatonin
Authors: Liu Wenju , Chen Zhihao , Li Rui , Zheng Menghao , Pang Xunsheng , Wen Aiyou , Yang Bing , Wang Shujuan
Published: January 2023

Background

Communication between oocytes and granulosa cells ultimately dictate follicle development or atresia. Melatonin is also involved in follicle development. This study aimed to investigate the effects of melatonin and its receptor antagonists on hormone secretion, as well as gene expression related to hormone synthesis, TGF-β superfamily, and follicle development in bovine granulosa cells, and assess the effects of melatonin in the presence of 4-P-PDOT and luzindole.

Methods

Bovine ovaries were collected from a local abattoir and follicular fluid (follicle diameter 5–8 mm) was collected for granulosa cell isolation and culture. Granulosa cells and culture medium were collected 48 h after treatment with melatonin at high dose concentrations (10−5 M) and low dose concentrations (10−9 M) in the absence/presence of 4-P-PDOT and luzindole (10−5 M or 10−9 M). Furthermore, the expression level of genes related to hormonal synthesis (CYP11A1, CYP19A1, StAR, and RUNX2), TGF-β superfamily (BMP6, INHA, INHBA, INHBB, and TGFBR3), and development (EGFR, DNMT1A, and FSHR) were detected in each experimental group by real-time quantitative PCR. In addition, the level of hormones in culture medium were detected using ELISA.

Results

Both 10−5 M and 10−9 M melatonin doses promoted the secretion of inhibin A and progesterone without affecting the production of inhibin B and estradiol. In addition, both promoted the gene expression of INHA, StAR, RUNX2, TGFBR3, EGFR, and DNMT1A, and inhibited the expression of BMP6, INHBB, CYP11A1, CYP19A1, and FSHR. When combined with different doses of 4-P-PDOT and luzindole, they exhibited different effects on the secretion of inhibin B, estradiol, inhibin A, and progesterone, and the expression of CYP19A1, RUNX2, BMP6, INHBB, EGFR, and DNMT1A induced by melatonin.

Conclusion

High and low dose melatonin receptor antagonists exhibited different effects in regulating hormone secretion and the expression of various genes in response to melatonin. Therefore, concentration effects must be considered when using luzindole or 4-P-PDOT.
Dimensões da Hospitalidade no Turismo de Base Comunitária
Authors: Budel Luana , Severini Valéria Ferraz , Rejowski Mirian
Published: January 2023

Em Mangabeira, Pará, a comunidade ribeirinha mantém tradições relacionadas ao sistema culinário de da mandioca. Originada de uma tradição ancestral inicialmente de matriz indígena, a mandioca é a base da cultura alimentar regional, estruturada em padrões de produção e consumo com especificidades locais. Desde 2019 acontecem roteiros turísticos específicos nessa região, com o intuito de proporcionar uma vivência de todo o processo de fabricação da farinha de mandioca. Esse tipo de turismo de base comunitária possibilita maior integração entre os sujeitos da hospitalidade e pressupõe a acolhida do outro. A partir de uma pesquisa qualitativa e exploratória, baseada em observação assistemática, observação participante e entrevistas abertas, objetiva-se analisar o roteiro turístico organizado pelo Instituto Laurinda Amazônia em Mangabeira, identificando as dimensões simbólicas da hospitalidade centrada na casa de farinha. Para tanto, apresenta-se a cultura alimentar local e os artefatos utilizados na produção da farinha, analisados a partir dos ritos de acolhimento na recepção, acomodação, alimentação e entretenimento dos visitantes. Revelam-se as dimensões simbólicas da hospitalidade a partir do mito da mandioca, dos objetos, do manejo e saberes, do espaço e do modo de vida na comunidade.
Mercado das viagens para concursos públicos no Brasil
Authors: Lobato Flavio Henrique Souza
Published: January 2023

Este estudo objetivou analisar o mercado das viagens para concursos públicos no Brasil, a partir do perfil e das experiências de concurseiros que viajam em busca de aprovação em cargo público. Os procedimentos metodológicos empregados para esta investigação, sob uma abordagem quali-quantitativa, exploratória e descritiva, se estabeleceram a partir de pesquisas bibliográfica, documental e de campo. Ao buscar estabelecer uma “netnografia” na ambiência cibernética da rede social Facebook, foram realizadas incursões virtuais, observações/acompanhamentos de interações, de postagens e de depoimentos entre internautas de grupos de estudo para concursos públicos. Ademais, conceberam-se conversas informais (bate-papos), capturas de tela (Print Screens) e aplicação de questionários. Os resultados obtidos permitiram depreender que as viagens a concursos públicos compreendem pessoas que viajam, em um espaço de tempo determinado, para concorrer a vagas no serviço público, mas que também realizam gastos para desfrutar de atividades de lazer e de turismo. Assim, identificou-se a existência de dois perfis de concurseiros que viajam: o viajante e o visitante. Com efeito, dada a demanda de inscritos, essas viagens estabelecem uma movimentação social e econômica nas destinações onde são aplicadas as provas, pois, tanto o mercado turístico quanto outros mercados, diretos ou indiretos, se beneficiam.
A proposed taxonomy of test-taking action and item format in written receptive vocabulary testing
Authors: Martin Jeffrey
Published: January 2023

Abstract
The functioning of a vocabulary testing instrument rests in part on the test-taking actions made possible for examinees by item format, an aspect of test development that warrants consideration in second-language vocabulary research. For example, although iterations of the written receptive vocabulary levels test (VLT) have integrated improvements in lexis sampling and distractor-item creation (i.e., Beglar & Hunt, 1999, Nation, 1983, 1990, Schmitt et al., 2001, Webb et al., 2017), its clustered form-meaning matching format has remained fundamentally unchanged. This study qualitatively explores the influence of this test item format on test-taking actions observed when taking the updated vocabulary levels test (UVLT, Webb et al, 2017). Data from a think-aloud protocol and retrospective interviewing indicated the predominant use of test-taking strategies for answering test items on the UVLT, such as bidirectional matching and elimination of cluster options, and that these actions enabled correct responses for clusters of target vocabulary about which the test taker demonstrated partial or even no knowledge. This evidence at the interface of test taker and test draws attention to the interconnection of estimating learners’ vocabulary knowledge and the action possibilities provided by item format on vocabulary tests. Such affordances are hierarchically structured in a proposed Taxonomy of Test-taking Actions Afforded by Receptive Vocabulary Test Format as a heuristic to evaluate the influences of test format on written receptive vocabulary assessment.
Vocabulary networks workshop 2: Activating words in a network
Authors: Meara Paul , Miralpeix Imma
Published: January 2023

Workshop 2 explores some larger vocabulary networks than those presented in Workshop 1 (1,000 words instead of 100), and introduces some additional ways of activating words in a network (e.g., by using new parameters in our models). The simulations will show that raising a network’s activation level may not be as easy as we would have expected, and that different kinds of events may cause either temporary or permanent changes in the networks. Findings will be discussed in relation to the previous literature on passive and active vocabularies. Several implications for vocabulary learning and teaching will also be considered.
Crypto Price Prediction as an Investment Opportunity: An Empirical Study of Three Global Cryptocurrencies
Authors: Taryanto Renaldi , Syahbandi . , Wendy . , Mustaruddin . , Afifah Nur
Published: January 2023

Aims: To determine the investment feasibility of evaluating cryptocurrency opportunities as an investment product under the possibility of crypto price valuation selection. The study analyzes three indicators: asset price returns in unrelated time, selection of cryptocurrency investment price weights, and crypto price forward contract opportunities on ARCH-GARCH probability forecasts in the selection of price valuations by individual cryptocurrency prices.

Study Design: Quantitative research.

Place and Duration of Study: The period from 10 September 2021 to 4 September 2022 using sample data downloaded from the Yahoo Finance website database with metric data retrieval bound in amount, data quantity, or distance relative to writing opportunities to examine the distribution of the amount of research data.

Methodology: This study employed Bitcoin (BTC), Ethereum (ETH), and Tether (USDT) cryptocurrencies as the research objects with used panel and multiple regression analysis methodologies and using forecasting the appropriate ARCH and GARCH methods

Results: The results show that the prediction of future crypto price selection in BTC and ETH tokens has a probability of 78.6% and 59.6%, respectively. The study highlights the prediction of future BTC and ETH price selection with 79.21% and 78.64% forecast results as found in the ARCH-GARCH(1, 0, 1) technique. Meanwhile, USDT token has no possibility to be forecasted in the future, leaving a 7.3% possibility of crypto price selection under probability by investors in the form of high (or different) price fluctuation inequalities.

Conclusion: Conclusions could state that the partial (combined) selection of crypto coin price assessments and individual crypto assets can reduce the expected return from the selection of the asset price so that this form of investment in crypto assets can reduce the level of observation of return on wealth from crypto assets for investors especially in expecting the chance on that investment.
The Impact of Decreasing Forest Areas on Increasing Global Temperatures
Authors: Faradiba Faradiba
Published: January 2023

Forests act as a producer of oxygen which is essential for the survival of living things. Degradation of forest areas causes the extinction of various species. It creates a greenhouse gas effect that impacts global warming, triggering regional climate change. This study aimed to determine the effect of decreasing forest area on increasing the annual average temperature in the world. The data used in this study are world forest area data and world average yearly temperature during the 1990-2020 period, with the addition of carbon emission data as a control. The analytical method uses Ordinary Least Square (OLS). The results obtained in this study, namely a decrease in every 1 km2 of forest area, will have a positive impact on increasing the annual average temperature. There was a significant influence in 1990-2010 with an increase in the country's average temperature of 0.0037225oC. An increase in carbon emissions of 1 ppm increases temperature by 1.046833oC. The results of this study illustrate that the reduction in forest area increases temperature, which triggers global climate change. Particular policies are needed from the government to maintain forest sustainability so that the ecosystem is maintained.
Evaluation of the Effects of Aqueous Extract of Sarcocephalus latifolius on Sexual Behaviour in Male Rats
Authors: Yaya Soro Tianga , Louise Ahui Bitty Marie , Mamadou Dosso , Koffi Severin , Sirabana Coulibaly
Published: January 2023

Background: Sarcocephalus latifolius, a plant of the Rubiaceae family, is found exclusively in tropical Africa, more particularly in sub-Saharan West Africa, stretching from Senegal to Zaire, but is also found as far east as Sudan (Sudan-Guinean zone). The leaves of this plant are used in traditional African medicine to treat numerous pathologies such as infertility.

Aims/Objective: The present study aims to evaluate the effects of the aqueous extract of Sarcocephalus latifolius leaves on sexual parameters in male rats.

Methods: The sexual parameters (latency of the mating position, latency of intromission, latency of ejaculation and mean copulation interval) were assessed by the classical method by administering distilled water, sildenafil citrate (reference molecule) called Viagra at the dose of 5 mg/kg of body weight and the aqueous extract of Sarcocephalus latifolius leaves at the dose of 1000 mg/kg of body weight per day for eight days to three batches of male rats respectively. These parameters were determined over a period of thirty minutes.

Results: The results obtained show that the aqueous extract of Sarcocephalus latifolius leaves at a dose of 1000 mg/kg of body weight significantly (P < .001) decreases the latency time of mating position and the latency time of intromission, whereas this extract significantly (P < .001) increases the latency time of ejaculation and the average copulation interval.

Conclusion: Aqueous extract of Sarcocephalus latifolius leaves has aphrodisiac properties which are due to sterols, flavonoids and saponosides.
Durational Effect of Cement Dust Exposure on Haematological Profile of Albino Rat
Authors: Ike Amalachukwu Okwukwe , Ogenyi Samuel Ifedioranma , Chinemerem Achilefu, Ramson , Blessing Okwuanaso Chetachi , Eberechukwu God’sman Chidugam
Published: January 2023

Background: This research work studied the durational effects of cement dust inhalation on the haematological parameters of exposed Albino rats. In this study, a glass house animal exposure chamber was fabricated using a plexi-glass and two blowing fans of adjustable revolution.

Methodology: Twenty five Albino rats were divided into five groups. Group A served as the control, while group B, C, D and E served as the test, and were exposed for 15, 30, 45 and 60 days interval respectively, for one hour daily to cement dust (200g), at a revolution of 3000rpm of the fans. At the end of the exposure, the animals were sacrificed, blood collected in EDTA bottle and was analysed for some haematological variables.

Results: The result showed that there were significant durational increase (p < 0.05) in the levels of Packed Cell Volume (PCV), Haemoglobin (Hb), Red Blood Cell (RBC), Lymphocyte, Monocytes and Eosinophils of the test group compared to control group but there was no significant difference in the Wbc, Basophils, Platelets and Neutrophils levels among the groups (p >0.05).

Conclusion: There is a durational exposure haematotoxic effect of cement dust inhalation on rat exposed to cement dust.
Interaction Effect of Chickpea (Cicer arietinum L.) Crop to Sulphur and Zinc Elements
Authors: Gautam Rahul , Mishra U. S. , Singh Vivek Kumar , Patel Veerendra Kumar
Published: January 2023

A field experiment was convened objective to study the interaction effect of chickpea (cicer arietinum L.) crop to sulphur and zinc elements on growth and yield attributes under rainfed condition during the Rabi season 2019-20. On a study sandy loam soil having low status of available nitrogen, low status of available phosphorus and medium status of available potassium. The treatment consisted of four levels of Sulphur (0, 20, 30 and 40 kg S ha-1) and four levels of zinc (0, 10, 15 and 20 kg Zn ha-1) applied from gypsum and zinc sulphate respectively. The findings result that the combination of S40 Zn15 recorded at before harvesting stage highest plant height (59.79 cm) and maximum root length at 45 DAS 14.82 cm & general mean 14.20 cm, maximum number of nodules plant-1 at 60 DAS 14.78 & general mean 11.40, the general mean was 54.3 pods plant-1, general mean value 186.6 g of test weight (1000 seeds), maximum grain yield 1399 kg ha-1, maximum stover yield 2085 kg ha-1. Chickpea variety GNG-469 (Samrat) was grown with the recommended agronomic practices. The synergistic effect of Sulphur and Zinc was reported on plant height, number of pod plant-1, number of seed pod-1 and seed yield.
Soxhlet Extraction of Spirogyra sp. as an Energy Source and Physicochemical Characterization of Produced Biodiesel
Authors: Kumar Rupesh , D’Souza P. M.
Published: January 2023

Due to industrialization demand of energy is increasing and hence to meet the demand without any compromise in growth and development, alternative source of energy needs to be found. The best alternative source is biofuels which are extracted from organic compounds. Algae are aquatic organisms almost available in every type of water bodies and considered as potential candidates for biodiesel productions at large scale. In present study, an experimental set –up was designed to produce algal oil through transesterification process. The Soxhlet extraction method is employed as an oil extraction method. The solvent utilized for oil extraction method is n-hexane, petroleum ether and mixture of both solvents to extract the algal oil.  Also the oil extracted from the algae is characterized to identify the suitability of algal biodiesel as a potential biofuel for internal combustion (IC) engine. The characterization revealed that physicochemical properties of obtained biodiesel were in permissible range in comparison with standard diesel fuel.
Incubation Studies to Find Out the Transformation of Different Fractions of Boron
Authors: Lamare Ruhiwanse , Sarangthem Indira
Published: January 2023

An incubation study was conducted in the laboratory of College of Agriculture, Central Agricultural University, Manipur, India, to know the transformation of applied Boron (B) in soils at field capacity. Soil samples was collected periodically at 0, 30, 60 and 90 days after incubation (DAI) and analyzed for different fractions of B. The experiment was carried out under completely randomized block design (CRD). Altogether there were 6 treatment replicated thrice namely, T0= Control, T1= 0.5 mg B kg-1 soil, T2= 1 mg B kg-1 soil, T3= 1.5 mg B kg-1 soil, T4= 2 mg B kg-1 soil and T5= 2.5 mg B kg-1 soil. From the incubation experiment, it was inferred that with applied B, the organically bound B fraction was higher next to residual form when compared to other forms of B. At 30 days of incubation, different fractions of B showed an increasing trend for added levels of B compared to control due to recently applied B into the soil solution. However, at 60 and 90 days different fractions of B in the soil started decreasing due the fact that boron entered into tightly bound state within the soil. In general, B fertilization increased the availability of B content in soil and hence increased its availability to the crop. The sequence of the content of different fractions of B in an acid soils of Imphal-West district was readily soluble-B>organically bound-B>oxide bound-B> specifically adsorbed-B> residual-B.
The interaction between the catalytic A subunit of calcineurin and its autoinhibitory domain, in the yeast two‐hybrid system, is disrupted by cyclosporin A and FK506
Authors: Chaudhuri Bhabatosh , Hämmerle Marcus , Fürst Peter
Published: July 2002

The Ca2+‐calmodulin dependent protein phosphatase, calcineurin, is thought to mediate the action of the two immuno‐suppressants, cyclosporin A (CsA) and FK506. Calcineurin from all species consists of a catalytic A subunit and a regulatory peptide B, which plays an essential role in catalysis. The enzymatic function is probably also regulated by an autoinhibitory domain (AID) present in the catalytic subunit. We have used the yeast two‐hybrid system to show that the putative AID of the yeast catalytic subunit Cna1 binds only to truncated Cna1, devoid of AID. Although deletion of the genes encoding the yeast catalytic subunits of calcineurin (CNA1 and CNA2) maintain the interaction, absence of the regulatory subunit Cnb1 prevents binding. Interestingly, both CsA and FK506 disrupt this interaction, whereas binding of Cna1 to calmodulin remains unaffected. This indicates that a simple cellular system, developed in yeast, could provide further insight into an understanding of calcineurin inhibition.
4‐Hydroxyphenethyl alcohol — a new cytokinin‐like substance from the phototrophic purple bacterium Rhodospirillum rubrum 1R
Authors: Serdyuk Olga P. , Smolygina Lidiya D. , Muzafarov Eugine N. , Adanin Vladimir M. , Arinbasarov Michael U.
Published: July 2002

Three compounds with cytokinin activity have been isolated from the medium of Rhodospirillum rubrum grown photosynthetically. Two N‐6 aminopurine cytokinins revealed in the medium were identical with those obtained from R. rubrum cells previously. The third compound with cytokinin activity in Amaranthus caudatus bioassay proved to be a simple phenolic compound with elemental composition C8H10O2. This cytokinin‐like substance according to absorption spectra, mass spectrometry and 1H NMR spectra data was identified as 4‐hydroxyphenethyl alcohol.