bluuebunny/crossref_metadata_2025 huggingface dataset:
Diabetes Gestacional – Rastreio Pós-parto
Authors: Carocha Ana , Rijo Cláudia , Amaral Njila , Aleixo Francisca , Rocha Tiago
Published: July 2022

Introduction: One third of women with gestational diabetes mellitus (GDM) will have diabetes or impaired glucose metabolism at postpartum screening. Objective: Evaluate the percentage of women submitted postpartum screening and associate the result with maternal history. Methods: Retrospective investigation of 1013 pregnancies with GDM (2005-2009). We divided the population into two groups according to the result: normal (group 1) and with diabetes or impaired glucose metabolism (group 2). For both groups we evaluated maternal age, body mass index, weight gain during pregnancy, need for insulin therapy, risk factors for GDM, and newborn weight. Results: Postpartum screening was achieved in 76.8% of women (n=778). The test was considered normal (group 1) in 628 women (80.7%) and modified (group 2) in 150 women (19.3%). Group 2 had older women (median age 34 vs. 33 years; p-value 0.013), higher body mass index (28.5 vs. 25.8kg/cm2; p-value 0.000), more women with diabetes mellitus family history in first degree (50.3% vs. 39.9%; p-value 0.026) and prior personal history of macrosomia (12.1% vs 5.4%; p-value 0.003). Earlier diagnosis of GDM was also made in this group (27 vs. 31 weeks; p-value 0.000) and a higher percentage had made insulin therapy (41% vs. 15%; p-value 0.000), having started earlier (28 vs 30 weeks; p-value 0.010). There was a higher percentage of multiparous pregnant in group 2 (64% vs 49.4%; p-value 0.001) and a larger number of cases of newborns large for gestational age (17.1% vs 8.3%; p-value 0.001). Personal history of GDM and weight gain during pregnancy was similar in both groups. Conclusions: Women who test abnormal in postpartum screening are usually older, heavier, multiparous, with a family related to DM patients and prior personal history of macrosomia. GDM diagnosis is made ealier in pregnancy, more often they need insulin therapy started ealier and there was a higher number of newborns large for gestational age.
Tratamento da osteoporose em Portugal: tendência e variação geográfica.
Authors: Rocha Olavo , Lunet Nuno , Costa Lúcia , Barros Henrique
Published: July 2022

The drugs available in the Portuguese market, for the treatment of osteoporosis, have different mechanisms of action, efficacy, indications, safety profile, and cost, which may influence prescription and acquisition by patients.To describe the use of drugs for osteoporosis treatment (estimated by sales), between 1998 and 2004, and the geographical variation in the drug utilization, in 2004.Data was obtained from IMS Health for the sales of drugs used in the ambulatory treatment of osteoporosis, in the whole country, from 1998 to 2004, and by region, in 2004. For each group (bisphosphonates, raloxifene, calcitonins, Hormone replacement therapy (HRT) and calcium and vitamin D), we computed the sum of the amount of packages and the value of the sales in each year, regardless of the strength or the package size. For bisphosphonates, raloxifene and calcitonins, we computed the DDD (Defined Daily Dose) sold in Portugal. All consumption data are presented by women aged 45 to 74 years. National data was used to describe the trends in sales, from 1998 to 2004, and regional data was used to map the 2004 consumptions.The expenses with drugs used in osteoporosis increased 60% from 1998 to 2004. The bisphosphonates sales increased more than five times, and in 2004 this group was responsible for 60% of the national market of drugs for osteoporosis treatment. Raloxifene represented approximately 10% of the sales in 2004. The consumption of calcitonins decreased nearly 70% in the observation period. The use of HRT increased 30% to 40% until 2001/2002, and decreased just about the same from there on. Geographical differences were observed in the sales of osteoporosis drugs in 2004, the amplitude of variation ranging from two (bisphosphonates, calcium and vitamin D, HRT) to three times (raloxifene, calcitonins) across regions. The lowest consumptions were observed in Beja and Bragança, and the highest in Aveiro. Raloxifene is used mainly in the Northwest of the country, and HRT in the sea side regions.In Portugal, the trends in the consumption of drugs used for osteoporosis treatment, as well as the relative weight of each pharmacological group, follow a similar pattern to the observed in other countries. The differences in consumption across the years and regions may reflect a variation in the frequency of disease or in the proportion of subjects being treated, but the magnitude of the variation suggests that there are unmet needs in diagnosis and treatment of osteoporosis in our country, and that social and economic factors may contribute to the regional differences observed.
A Phenomenological Study on Trauma Clients’ Experiences of Somatic Experiencing
Authors:   The Association of Korea Counseling Psychology Education Welfare, KONG Choon-Ok , CHOI Han-Na
Published: July 2022

The purpose of this study is to understand how clients with trauma would experience SomaticExperiencing (SE) as an approach to trauma therapy, and determine the structure of theexperiences. A total of six including 5 females and 1 male. The data collected were analyzedaccording to the stages of qualitative analysis based on Giorgi’s phenomenological method,which has resultingly drawn five components of experiences that clients with trauma had alongwith 26 sub-components. The components are , , , , . The study results may provide useful baseline data of counselingintervention for clients with trauma for the reason that empirical basis of the experiences thatthe clients had during SE and vivid description of the counseling process has been provided,and the importance of the experience has been explored.
The Effect of Early Childhood Teacher’s Teaching Profession Passion to Happiness: Mediator Effect of Teacher Efficacy
Authors:   The Association of Korea Counseling Psychology Education Welfare, SHIM Young-Hee
Published: July 2022

This study attempted to examine the mediating effect of teacher efficacy in the effect of earlychildhood teachers' passion for teaching on happiness. The subjects of the study were 220infant teachers working at daycare centers in Daegu, and the collected data were analyzed usingSPSS 25.0, hierarchical regression analysis, and Sobel verification method.. Data was collectedand analyzed correlation, hierarchical multiple regression and sobel test. The results of thisstudy are as follows. First, it was found that there was a significant positive correlation betweenearly childhood teachers' passion for teaching, teacher efficacy, and happiness. Second, amongthe sub-areas of passion for teaching, passion and harmonious passion were found to have apositive effect on external happiness, internal happiness, and self-regulation happiness throughteacher efficacy.
Analysis of Research Trends on University Counseling Centers: 1979∼2021
Authors:   The Association of Korea Counseling Psychology Education Welfare, HWANG Hye-Jung
Published: July 2022

The purposes of this research were to analyze research trends on university counselingcenters, to improve in-depth understanding of the centers, and to suggest future developmentaldirections for the university counseling centers. For this, 57 research papers on universitycounseling centers from 1979 to 2021, were analyzed. The analysis results are as follows. First,many research papers on university counseling centers were performed from 2010s. Second,academic journals were published more than theses. Third, the number of research authors wasmainly one, and joint researches were increased. Fourth, there was no difference betweenquantitative and qualitative researches. Fifth, the subjects were mainly university students andcounselors. Sixth, major research topics were actual conditions and perceptions of centers, andcounselors’ characteristics and supervisions.
Erratum: White paper: definitions of artificial intelligence and autonomous actions in clinical surgery
Authors: Gumbs Andrew A. , Alexander Frank , Karcz Konrad , Chouillard Elie , Croner Roland , Coles-Black Jasamine , de Simone Belinda , Gagner Michel , Gayet Brice , Grasso Vincent , Illanes Alfredo , Ishizawa Takeaki , Milone Luca , Özmen Mehmet Mahir , Piccoli Micaela , Spiedel Stefanie , Spolverato Gaya , Sylla Patricia , Vilaça Jaime , Abu Hilal Mohammad , Swanström Lee L.
Published: July 2022

No
Moderating role of customer value on the effect of animosity, ethnocentrism and religiosity toward purchase decision: study on Chinese cosmetic
Authors: Asyhari Asyhari , Yuwalliatin Sitty
Published: July 2022

Purpose – This study aims to examine the moderating role of customer value on the relationship between animosity, ethnocentrism, and religiosity on purchasing decisions of Chinese brand cosmetics.
Design/methodology/approach – This study used a quantitative research design. Selected 150 millennial in the city of Semarang as samples was taken using the purposive sampling technique. The data were analyzed using a moderated PLS-SEM.
Findings – The results showed that hostility, ethnocentrism, and religiosity had a negative and significant effect on purchasing decisions. The study also found that customer value actually becomes a moderator that can weaken the relationship between these three variables on purchasing decisions.
Research limitations/implications – Data were collected from millennial in the city of Semarang. This condition causes limitations as it may not capture reflections from other age groups that are different from the sample. Thus, further marketing studies are needed with comprehensive respondent characteristics, increasing the number of samples, and including other moderating variables such as the level of customer trust.
Practical implications – The empirical findings of the current study help international businesses in understanding negative factors as antecedents of purchase decisions. This will be useful in planning marketing activities and efforts to increase market share. In addition, managers can consider the customer value to gain the trust of customers.
Originality – The study on the negative influence of animosity, ethnocentrism, and religiosity on purchase decisions in Indonesia is very limited. This study focuses on explaining the importance of customer value as a moderating factor, in anticipation of the negative relationship. This study contributes to multinational companies understanding the consumer purchase decision.
When follower believe in co-production leadership: why do personal characteristics matters?
Authors: Sunaryo Sinto , Suyono Joko , Sarjiyanto Sarjiyanto , Effendi Adnan , Risgiyanti Risgiyanti
Published: July 2022

Purpose – The present study aims to analyze personal characteristics that potentially affect the belief in co-production leadership and its effect on behavior based on the belief. This study also attempted to determine the impact of the leadership romance role on the relationship between coproduction leadership and the intention to obey the leader.
Design/methodology/approach – The research used a survey method with a quantitative approach. Out of 250 distributed questionnaires, only 149 questionnaires met the criteria. Partial Least Square Structural Equation Modelling (PLS-SEM) was used to test the proposed hypotheses.
Findings – The result of the study showed that the values of collectivism positively associated with the co-production leadership belief. However, the study also found that the values of individualism had no significant effect on the co-production leadership belief. Surprisingly, the result also showed that the co-production leadership belief positively affected the leader's intention to obey.
Research limitations/implications – This study addressed political parties as the object of the study, so thoroughness in generalizing the result of the study to other objects is needed. The study's design is cross-sectional, which limits the researcher's in-depth analysis of workplace violence phenomena since the data being studied is only based on one period of time. Lastly, the data for analysis were limited to the respondents’ responses to statements in the questionnaire. More information could be obtained by conducting an in-depth interview with the respondents.
Practical implications – The result of this study indicated that the romance of leadership moderates the relationship between the co-production leadership and the intention to obey the leader. This study opens new avenues for research on organizational cynicism and carries implications for theory and practice.
Originality/value – This study attempts to answer the question about whether each individual with different characteristics (high values on individualism-collectivism) possess a different belief related to followership role orientation (i.e. co-production leadership). The study also examines whether this belief determines followers' behavior on leadership process.
The effect of destination attractiveness on destination attachment and its impact on tourist sustainable behavior
Authors: Pratminingsih Sri Astuti , Johan Ahmad , Salsabil Imanirrahma
Published: July 2022

Purpose – In gaining competitive advantage in the tourism context, Bandung City needs a good marketing strategy. This study aims to determine the influence of destination attractiveness on destination attachment and its impact on tourist sustainable behavior in Bandung, West Java.
Design/methodology/approach – This study used a descriptive verification approach. The number of samples is 151 tourists who were randomly selected using incidental techniques. The data analysis is carried out using SEM with Amos 22 software. The data were collected through questionnaire, notes and publication, and literature study.
Findings – The results of this study indicate that the attraction given by a destination directly influences tourists to make return visits. Destination attractiveness has an influence on destination attachment. This study also found that the mediating effect of the tourist destination attachment on the relationship between destination attractiveness and sustainable behavior is very small.
Research limitations/implications – Future research is suggested to consider other variables that are able to mediate the influence of tourist attraction on return visits or sustainable behavior.
Practical implications – As destination attractiveness positively affects sustainable behavior of tourist, this study provides insight for the government of Bandung city to make a good marketing strategy in order to create a competitive advantage in their destination.
Originality/value – This study answers to the suggestion from previous studies to identify and examine the mediators relevant to the attitude-behavior relationship in the context of tourism research.
ALCAM: A Novel Surface Marker on EpCAMlow Circulating Tumor Cells
Authors: Charles Jacob Harrys Kishore , Signorelli Rossana , Giret Teresa Maidana , Umland Oliver , Hadisurya Marco , Lavania Shweta , John Lalith Charles Richard , Middleton Ashley Nicole , Boone Belinda Minucci , Ergonul Ayse Burcu , Tao Weiguo Andy , Amirian Haleh , Iliuk Anton , Khan Aliya Mahmood , Diaz Robert Alexander , Cortes Daniel Bilbao , Garcia-Buitrago Monica Tulia
Published: July 2022

Background: Current strategies in circulating tumor cell (CTC) isolation in pancreatic cancer heavily rely on the EpCAM and cytokeratin cell status. EpCAM is generally not considered as a good marker given its transitory change during Epithelial to Mesenchymal Transition (EMT) or reverse EMT. There is a need to identify other surface markers to capture the complete repertoire of PDAC CTCs. The primary objective of the study is to characterize alternate surface bi-omarkers to EpCAM on CTCs that express low or negligible levels of surface EpCAM in pancre-atic cancer patients. Methods: Flow cytometry and surface mass spectrometry were used to iden-tify proteins expressed on the surface of PDAC CTCs in culture. CTCs were grown under condi-tions of attachment and in co-culture with naïve neutrophils. Putative biomarkers were then validated in GEMMs and patient samples. Results: Surface proteomic profiling of CTCs identi-fied several novel protein biomarkers. ALCAM was identified as a novel robust marker in GEMM models and in patient samples. Conclusions: We identified several novel surface bi-omarkers on CTCs expressed under differing conditions of culture. ALCAM was validated and identified as a novel alternate surface marker on EpCAMlow CTCs.
Low Dose Rate Radiation Induced Secretion of TGF-β3 Together With an Activator in Small Extracellular Vesicles Modifies Low Dose Hyper-Radiosensitivity Through ALK1 Binding
Authors: Hanson Ingunn , Pitman Kathinka Elinor , Altanerova Ursula , Altaner Čestmír , Malinen Eirik , Edin Nina Frederike Jeppesen
Published: July 2022

Hyper-radiosensitivity (HRS) is the increased sensitivity to low doses of ionizing radiation observed in most cell lines. We previously demonstrated that HRS is permanently abolished in cells irradiated at a low dose rate (LDR), in a mechanism dependent on transforming growth factor β3 (TGF-β3). In this study, we aimed to elucidate the activation and receptor binding of TGF-β3 in this mechanism. T-47D cells were pre-treated with inhibitors of potential receptors and activators of TGF-β3, along with addition of small extracellular vesicles (sEVs) from LDR primed cells, before their radiosensitivity was assessed by the clonogenic assay. The protein content of sEVs from LDR primed cells was analyzed with mass spectrometry. Our results show that sEVs contain TGF-β3 regardless of priming status, but only sEVs from LDR primed cells remove HRS in reporter cells. Inhibition of the matrix metalloproteinase (MMP) family prevents removal of HRS, suggesting an MMP-dependent activation of TGF-β3 in the LDR primed cells. We demonstrate a functional interaction between TGF-β3 and activin receptor like kinase 1 (ALK1), by showing that TGF-β3 removes HRS through ALK1 binding, independent of ALK5 and TGF-βRII. These results are an important contribution to a more comprehensive understanding of the mechanism behind TGF-β3 mediated removal of HRS.
Bending Stresses and Deformations in Prismatic Profiled Shafts With Noncircular Contours Based on Higher Hybrid Trochoids
Authors: Ziaei Masoud
Published: July 2022

This paper presents an analytical method for determining the bending stresses and deformations in prismatic noncircular profile shafts with trochoidal cross sections. The so-called higher trochoids can be used as form-fit shaft–hub connections. Hybrid (mixed) higher trochoids (M-profiles) were proposed in [1] and adapted to a practical industrial application in [2]. M-profiles combine the advantages of standardised polygon (DIN 32711 [3]) and spline (DIN 5486 [4]) contours used as shaft–hub connections for the transmission of torsional loads. In this study, the geometric and mechanical properties of the higher hybrid trochoids were investigated using complex functions to simplify the calculations. The pure bending stress and shaft deflection were determined for M-profiles using the bending theory formulated by Muskhelishvili [5]. The loading cases consisted of static and rotating bends. Analytical, numerical, and experimental results agreed well.
On the Advantages and Disadvantages of Choice
Authors: Scaffidi Abbate Costanza , Miceli Silvana
Published: July 2022

Nowadays the freedom to make choices is considered of vital importance for decision-makers. Researchers investigating the psychological effects of choice provided empirical evidence about the many advantages of choice (i.e., increased intrinsic motivation, greater perception of self-determination, better performance, and greater life satisfaction). However, more recent studies demonstrated the downsides of choice. When the decision task difficulty exceeds the natural cognitive resources of human mind, the possibility to choose becomes more a source of unhappiness and dissatisfaction than an opportunity for a greater well-being. We here discuss in a detailed fashion the main findings of research in psychology and consumer behavior showing the bright sides and the downsides of choice.
Penentuan Rute dan Stasiun Transportasi Trem di Kecamatan Somba Opu, Kabupaten Gowa
Authors: Nabila Afifah , Akil Arifuddin , Sutopo Yashinta Kumala Dewi
Published: July 2022

Based on the general plan for the development of land transportation in 2015-2035, the Indonesian Ministry of Transportation has a direction for the development of urban mass public transportation in order to support movement between centers of activity and the provision of reliable and competitive transportation services. This study aims to identify the most influential factors in the consideration of determining routes and stations, determine potential tram routes, and determine the location of potential tram stations in Somba Opu Subdistrict. This research was carried out from October 2019 until April 2020, located in Somba Opu District, Gowa Regency. This research is a descriptive study, with quantitative and qualitative approaches. The analysis techniques used in this study were expert choice analysis, MAT and spatial analysis (desire line, network analyst, overlay, and grid-based. The results of this study indicate that: 1) The priority factors in determining the route are road network characteristics, community movement patterns, the distribution of activity centers, land use, and population distribution, while in determining the location of the station the priority criteria are close to the location of the generator. , location of attraction, as well as intermodal integration considerations; 2) The tram route of Somba Opu Subdistrict passes arterial and collector roads (Jl. Sultan Hasanuddin - Jl. Andi Mallombasang - Jl. Poros Malino); 3) The potential location to become a station location is the grid which has a value of 86% -100% (very potential). The tram station is located on Jl. Andi Mallombasang, Sungguminasa Village.
Effects of impure water sources on early-age properties of calcium sulfoaluminate cements for rapid airfield damage recovery
Authors: Long Wendy , Doyle Jesse , Martinez-Guerra Edith , Griggs Christopher
Published: July 2022

In austere environments with limited access to clean water, it is advantageous to use nonpotable water for construction (i.e., mixing water for concrete.) In rapid-response situations such as rapid airfield damage recovery (RADR), the use of calcium sulfoaluminate (CSA) cements is beneficial for expedient pavement repairs because of their rapid strength gain characteristics. However, the hydration products formed by CSA cements are substantially different from those formed by ordinary portland cement and might react differently to impurities that water sources may contain. A laboratory study component investigated the application of various salts and impure sources of mixing water with commercially available CSA cement-based products. A field component studied the application of naturally occurring impure water sources for RADR. Recommendations are made for implementation of impure mixing water for RADR using commercially available flowable fill and concrete products made with CSA cement.
Advanced Well Control
Authors: Watson David , Brittenham Terry , Moore Preston L.
Published: July 2022

A valuable reference for students, working engineers, and supervisors alike, Advanced Well Control addresses all phases of well control, from the design stage of a well through plug and abandonment. The fundamental science underlying the techniques is discussed, and the practical application of the concepts is covered in detail and demonstrated with example problems.
Transient Well Testing
Authors: Kamal Medhat M.
Published: July 2022

Transient well testing provides indirect determination of reservoir and well parameters. It is one of the most important in a spectrum of diagnostic tools used by petroleum engineers to characterize hydrocarbon assets and predict their future performance. This new monograph is the go-to handbook for designing, running, and analyzing different types of transient tests in oil and gas reservoirs. Since the publication of SPE’s last monograph on well testing, considerable advances in testing tools, computing technology, and theoretical development have continued to enhance the information that can be obtained from transient testing and change the methods of interpretation. A gap in the petroleum engineer’s library for a comprehensive book covering the state of the art in well-test analysis has existed for some time now. Practicing petroleum engineers need a single up-to-date reference for transient testing of oil, gas, and water wells; Transient Well Testing has been written to fill that gap.

Errata (http://go.spe.org/TWTerrata)
Analysis of Production Decline Curves
Authors: Poston Steven W. , Poe Bobby D.
Published: July 2022

Long ago, engineers recognized the characteristic decline of oil and gas well performance and attempted to predict its course by fitting equations to the production history. This book covers the production characteristics and associated interpretation analyses of petroleum reservoirs in a complete, thorough, and consistent manner. Production decline-curve analyses are the most widely used tool in the industry for oil and gas reservoir production analyses. This book will serve as an authoritative reference on modern production decline-curve analyses, including details of some recent advances in the technology.
The Reservoir Engineering Aspects of Waterflooding
Authors: Warner H.R. “Hal”
Published: July 2022

The first edition of The Reservoir Engineering Aspects of Waterflooding was published in 1970 and written by Forrest F. Craig, Jr. At the time of publication, much of the theory of oil displacement by water had been developed and many laboratory studies completed; however, the ability to perform computer modeling of 3D fluid flow in reservoirs with complex geologic depositions was in its infancy. In addition, several of the earliest, large-scale field applications of pattern waterflooding had begun, but long-term performance results were not yet known, and various infill drilling programs had yet to be implemented. This second edition reviews the fundamentals of waterflooding theory, and the experimental studies undertaken to understand the water displacement of oil in one, two, and three dimensions.
Unconventional Gas and Tight Oil Exploitation
Authors: Aguilera Roberto
Published: July 2022

Unconventional Gas and Tight Oil Exploitation takes an in-depth look at unconventional low-permeability resource accumulations, the required technologies for specialized development, and the assessments currently being applied. With an author team of 14 subject-matter experts with specialization in different tight oil and unconventional-gas areas, this new book is an authoritative resource for those looking to increase recoverable resources. A must read for those wanting to make a significant positive impact on global energy markets while respecting the environment.
Fuzzy analytic hierarchy process with ordered pair of normalized real numbers
Authors: Cui Haoyang , Zhang Hui , Zhou Lei , Yang Chunming , Li Bo , Zhao Xujian
Published: July 2022

The Analytic hierarchy process (AHP) is a widely used multi-criteria decision theory, and most AHP relies on the judgments of experts to derive priority scales. However, the judgment of experts may be subjective, and different experts may give different judgments for a problem. In order to make the decision results more objective, machine learning algorithms can be used to make the judgment. However, machine learning algorithms are strongly related to the collected data and not being flexible enough. This paper tries to combine expert judgments with algorithmic judgments to improve the bias of experts' judgments while still making decision-making flexibility. The authors combine expert's judgments with the judgments of the machine learning algorithm into Ordered pair of normalized real numbers (OPNs) and then make decisions through OPNs. Experiments on real data sets show that the proposed algorithm can get reasonable decision results. Moreover, when the expert's judgments are wrong or invalid, the judgments given by the machine learning algorithm can correct the expert's judgments to obtain a reasonable decision-making result.
Computational approach to examine Interactivity between locomotion of bacteria and FENE-P slime adhere to slippery surface
Authors: Asghar Zeeshan , Shah Rehman Ali , Ali Nasir
Published: July 2022

Motility is a fundamental attribute of bacteria and is one of the common traits shown by it. Many bacteria swim freely in a fluid via rotation of flagella filament, while on the other hand many of them have developed a several varieties of cell motility mechanism without the aid of flagella. The later type of motility mechanism is adopted by rod-shaped bacteria known as gliding bacteria. These gliding bacteria can secrete an extracellular polymeric substance that allow them to move without flagella. This mysterious motility of gliding bacteria has been very attractive to many researchers in recent years and have been studied theoretically/experimentally and mathematically. In the current analysis, a mathematical fluid model (FENE-P) is used to explicate the motility of gliding bacteria on slippery, soft and rigid surfaces. For the mathematical description of the governing equations Cartesian coordinates are used. By utilizing the dimensionless variables, long wavelength and small Reynolds number approximation, the modeled partial differential equation are reduced into forth-order differential equation. The resultant highly non-linear ODEs for the large values of emerging parameters are numerically solved by Newton-Raphson technique. The study revel that the emerging parameters have major effects on gliding speed of the cell, flow rate of the slime and power consumed by the cell. The salient physical application of governing parameters is graphically underlined for soft and rigid surfaces. The outcomes are elaborated in detail further, it is renowned that the current analysis has many biomechanical applications such as it is relevant to marine anti-bacteria fouling and biofuel cell technologies.
Biliary granulomatous peritoneal reaction as consequence of cholecystectomy: a case report and a revision of the literature.
Authors: Tarantino Giuseppe , Menghini Denise , Argenziano Maria Eva , Palmieri Miriam , Mandolesi Alessandra , Bona Enrico Dalla , Benedetti Antonio , Guerrieri Mario , Danieli Maria Giovanna
Published: July 2022

Introduction: Bile or gallstone spillage during laparoscopic cholecystectomy occurs in 13 to 40% of cases of surgical dissection and extraction of very inflamed gallbladder with friable or gangrenous walls. Case presentation: We present a case of a patient who developed this rare complication after a difficult cholecystectomy for acute-on-chronic cholecystitis. Our patient, after about 2 years from the surgery, in the follow-up imaging studies, showed multiple nodules disseminated in the peritoneal cavity suggestive for malignancy both on abdomen computer tomography scan and on positron emission tomography. Thus, laparoscopic nodulectomy, lastly allowed histologic diagnosis of biliary peritoneal granulomatous reaction. Even if benign assessment of nodules’ nature, these lesions showed a progressive trend in increasing over the time in number and dimensions. We performed PubMed research of all cases reported in literature, to examine the cases features and to compare our findings with other clinical experiences reported by eleven international canters. Many patients were completely asymptomatic; as an occasional finding mimicking peritoneal seeding, further assessment to define the benign nature of these nodules were performed, so they underwent surgical treatment.In conclusion, development of multiple abdominal nodules resulting from a foreign-body granulomatous reaction to bile/gallstones is a quite rare event after laparoscopic cholecystectomy, but we believe it should be seriously considered in patients undergone complicated surgical procedures on biliary tracts.
Robot-Assisted Radical Prostatectomy: Accessory Pudendal Arteries Preservation and Effects on Sexual Functions
Authors: Arikan Yusuf , Seker Kamil Gokhan , Yenice Mustafa Gurkan , Kargi Taner , Tugcu Volkan
Published: July 2022

Background: Aim of this study was to show the importance of accessory pudendal arteries (APAs) on erectile function in patients who underwent robot-assisted radical prostatectomy (RALP).Methods: We retrospectively reviewed data of 988 RALP procedures performed in our institution between 2010 and 2018. 55 patients who were APA (+) and 76 patients who were APA (-) and underwent RALP procedures were included in the study. Demographic characteristics, preoperative clinical information, peroperative data and pathologic data were collected. IIEF-5 scores preoperatively and postoperative 3rd, 6th, 12th and 18th months, registered.Results: The mean age, in the study group was 61 ± 6.2 yeas. Mean BMI was 27.2 ± 1.8 kg/m2. The mean surgical duration was 161.9±24.7 minutes and the mean blood loss was 134.4±95.9 ml. Surgical time (170 min vs 150 min) and per-op blood loss (120 mL vs 100 mL) were significantly higher in the APA (+) group compared with APA (-) group (p < 0.05). There was no significant (p>0.05) difference in the preop IIEF-5 scores in APA (-) and APA (+) groups but IIEF-5 scores in postop 3rd, 6th, 12th and 18th months were significantly higher (p<0.05) in the APA(+) group compared to APA(-) group. No significant decrease was detected in IIEF-5 scorse in the postop follow-ups in either group (p<0.05).Conclusions: In this study, we showed that APA presence is an important factor in the preservation of sexual function and if APAs are detected, preservation of this arterial structure should be among the steps of RALP.
Alcohol-induced C/EBP β-driven KIAA1429 decreases oxidative stress and promotes pancreatic cancer growth and metastasis via the m6A/YTHDF2/SLC43A2 pathway
Authors: Wang Gang , Gao Lei , Lv Gaoyuan , Liu Ziying , Tang Desheng , Yan Changsheng , Ma Jiamin , Cheng Long , Li Le , Sun Bei , Tang Qiushi
Published: July 2022

N6-methyladenosine (m6A) is implicated in tumorigenesis. To data, the role of KIAA1429, an RNA methyltransferase in pancreatic cancer (PC) has not been clearly defined. The present study demonstrated that KIAA1429 was upregulated in PC. Overexpression of KIAA1429 accelerated PC proliferation and metastasis, whereas knockdown of KIAA1429 had an opposite effect. Mechanistically, KIAA1429 promoted the degradation of SLC43A2 mRNA via an m6A-YTHDF2 mechanism, and downregulation of SLC43A2 reduced phenylalanine absorption and oxidative stress, thus enhancing the progression of PC. In addition, alcohol induced the expression of C/EBP β, which bound to the promoter of KIAA1429 and boosted its transcription. The findings of the present study revealed a potential link between alcohol consumption, m6A and phenylalanine absorption in PC progression, providing a novel means to combat this disease.
Nanobodies Targeting ABCC3 for Immunotargeted Applications in Glioblastoma
Authors: Ruiz-López Eduardo , Jovčevska Ivana , González-Gómez Ruth , Tejero Héctor , Al-Shahrour Fátima , Muyldermans Serge , Schuhmacher Alberto J.
Published: July 2022

The cancer “omics” reveal many clinically relevant alterations that are transforming the molecular characterization of glioblastomas. However, many of these findings are not yet translated into clinical practice due, in part, to the lack of non-invasive biomarkers and the limitations imposed by the blood-brain barrier. Nanobodies, camelid single-domain antibody fragments, emerge as a promising tool for immunotargeted applications for diagnosing and treating glioblastomas. Performing agnostic bioinformatic analysis from glioblastoma patient datasets, we identified ATP Binding Cassette subfamily C member 3 (ABCC3) as a suitable target for immunotargeted applications. The expression of ABCC3 is associated with poor survival and impaired response to temozolomide. Importantly, high expression of ABCC3 is restricted to glioblastoma, with negligible levels in healthy brain tissue, and further correlates with tumor grade and stemness markers. We identified three immunogenic epitopes of ABCC3 which were used to isolate nanobodies from a glioblastoma-specific phage-display nanobody library. Two nanobodies targeting ABCC3 (NbA42 and NbA213) were further characterized and demonstrated in vivo selective recognition of ABCC3 in glioblastoma xenograft models upon systemic administration. We designate NbA42 and NbA213 as new candidates to implement immunotargeted applications guiding a more personalized and precise diagnosis, monitoring, and treatment of glioblastoma patients.
Magnetic Seed versus skin tattoo localization of non-palpable breast lesions: a single institution cohort study
Authors: D'Angelo Anna , Scardina Lorenzo , Palma Simone , Cicero Stefano Lo , Maresca Alessandro , Biondi Ersilia , Franco Antonio , Terribile Daniela , Franceschini Gianluca , Belli Paolo , Manfredi Riccardo
Published: July 2022

Background: The increasing number of diagnosis of non-palpable breast cancers has led to a need of constant improvement of imaging techniques preoperative localization. The current scenario counts different techniques, including: wire localization, radio-guided occult localization (ROLL), non-radioactive radar localization and skin tattoo. The choice of which one to use depends on surgeon’s and radiologist’s different skills. The introduction of magnetic seed localization technique facilitates the theater scheduling in the absence of same day radiology presence. Objective: The objective of this restrospective study was to investigated the accuracy and feasibility of Magseed compared to skin tattoo in the preoperative localization of impalpable breast lesions in terms of accuracy of placement, re-excision and positive margin rates and breast/surgical specimen volume ratio.Methods: From November 2020 to November 2021 we retrospectively analysed 77 patients. Results: 37 magnetic seeds were placed in 36 patients (48.6%) and 40 skin tattoos were performed in the remained cases (51.4%). With both methods, 100% of the index lesions were completely removed and found in the surgical specimen. The re-excision rate reported was 0% for both groups. Magseed was used with greater frequency in patients with small lesions (p=0.017) and medium breasts (B cup 62.2%). A significant difference was also observed in the breast parenchyma removed between Magseed group and skin tattoo (p=0.003), especially in case of small lesions. Conclusions: Magseed placement is a save, nonradioactive localization technique, that improves scheduling efficiency, recommended in case of impalpable, smaller lesions and medium-large breasts.
Building communities of practice through case-based e-learning to prevent and manage TB among people living with HIV–India
Authors: Agarwal Reshu , Agarwal Upasna , Das Chinmoyee , Allam Ramesh Reddy , Pant Rashmi , Ho Christine , Kumar B Ravi , Dabla Vandana , Moonan Patrick K , Nyendak Melissa , Anand Sunil , Puri Anoop Kumar , Mattoo Sanjay Kumar , Sachdeva Kuldeep Singh , Yeldandi Vijay V , Sarin Rohit
Published: July 2022

Background: Addressing TB among people living with HIV (PLHIV) is a key priority for the Government of India (GoI). In 2016, GoI implemented single-window services to prevent and manage TB in PLHIV. To strengthen HIV-TB service delivery, case-based e-learning was introduced to health care providers at ART centres (ARTc). Methods: We implemented a hub and spoke model to deliver biweekly, virtual, case-based e-learning at select ARTc (n=115), from four states of India-–Delhi, Uttar Pradesh, Andhra Pradesh and Tamil Nadu. We evaluated feasibility and acceptability of case-based e-learning and its impact on professional satisfaction, self-efficacy, knowledge retention using baseline and completion surveys, session feedback, pre-and post-session assessments. We reviewed routine programmatic data and patient outcomes to assess practices among participating ARTc. Results: Between May 2018–September 2020, 59 sessions were conducted with mean participation of 55 spokes and 152 participants. For 95% and 88% of sessions≥80% of respondents agreed that topics were clear and relevant to practice, and duration of session was appropriate, respectively. Session participants significantly improved in perceived knowledge, skills and competencies (+8.6%;p=0.025), and technical knowledge (+18.3%;p=0.04) from baseline. Participating ARTc increased TB screening (+4.2%,p<0.0001)), TB diagnosis(+2.7%,p<0.0001), ART initiation(+4.3%,p<0.0001) and TB preventive treatment completion (+5.2%,p<0.0001).Conclusion: Case-based e-learning is an acceptable and effective modus of capacity building and developing communities of practice to strengthen integrated care. E-learning could address demand for accessible and sustainable continuing professional education to manage complex diseases, particularly co-morbidities and thereby enhance health equity.
Experimental investigation and theoretical prediction of forming limit diagram of DP600 steel sheets
Authors: Zheng Qiuli , Yan Jiaming , Li Jieqing , Xu Xiaodong , Liu Haoyang , An Xiujuan
Published: July 2022

Dual phase steels are the ideal substitutes for conventional steels to reduce the weight of vehicles and decrease fuel consumption, and their mechanical properties have attracted much attention. Therefore, this work established strain-based forming limit diagrams (FLDs) for DP600 steel sheets by means of experimental investigation and theoretical prediction. To obtain the analytical limit strains in the biaxial and uniaxial tensile case, the Swift’s diffuse instability model and Hill’s localized instability model were adopted, respectively. The results showed that compared with the theoretical forming limit curve (FLC) predicted by Keeler equation, the theoretical FLCs predicted by the Hill'79 yield criterion or the Logan-Hosford yield criterion were more suitable for predicting the forming limit of DP600 steel sheets. The experimental results showed that the limit major strain of DP600 material is 41% under uniaxial tensile strain path, 43% under biaxial tensile strain path and 18% under plane strain path. Solutions from the analytical methods were compared with experimental FLD established based on combining uniaxial tensile tests and hydraulic bulging tests, only with an error of 3%, proving the rationality and accuracy of the theoretical prediction.
Device Association and Trajectory Planning for UAV-Assisted MEC in IoT: A Matching Theory Based Approach
Authors: Zhang Xinjun , Zhang Guopeng , Wang Kezhi , Yang Kun
Published: July 2022

Unmanned aircraft vehicle (UAV) -assisted mobile edge computing (MEC) is an effective way to alleviate the lack of energy and computing power of the Internet of Things (IoT) devices in remote areas. This paper considers the competition among multiple aerial service providers (ASPs) to provide UAV-assisted MEC services to multiple ground network operators (GNOs). We first quantify the conflicting interests of the ASPs and GNOs by different profit functions. Then, the system-wide UAV scheduling and resource allocation is formulated as a multi-objective optimization problem, where an ASP aims to reap the most profits from providing MEC services to the GNOs, while a GNO aims to seek the service of a certain ASP to meet its performance requirements. This problem is a mixed-integer nonlinear programming (MINLP), and we propose a matching theory based algorithm to solve it. We first investigate the UAV trajectory planning and resource allocation between a single UAV and a single service area, and solve it using the Lagrange relaxation and successive convex optimization (SCA) methods. According to the obtained results, the GNOs and ASPs are associated in the framework of the matching theory, which results in a weak Pareto optimality. Simulation results show that the proposed matching theory based algorithms achieve the considerable performance.
The Impacts of a Middle-School Art-based Program on Academic Achievements, Creativity, and Creative Behaviors
Authors: Egana-delSol Pablo
Published: July 2022

This article conducts an impact evaluation of an art-based program, implemented in public schools, on academic achievements, creativity, and socioemotional skills and behaviors. The main contribution with respect to previous literature is a quasi-experimental design that makes the causal link between these aspects more plausible. Four main findings are derived from the empirical investigation. First, participation in at least two semester-length workshops is a necessary condition to observe significant impacts. Second, participation has a significant impact on academic achievements. Grades increased by 0.61 standard deviations (sd) for language, by 0.36 sd for math, and by 0.33 sd for art. Overall GPA increased by 0.55 sd. The art-based program also increased participant willingness to consider postsecondary education. Third, the impact of the art-based program on various innovative graphical psychometric measures of creativity was positive and significant. Fourth, related to creative behaviors, the art-based program had a positive impact on certain cultural activities, such as time spent watching films at home and creating cultural goods (e.g., handicrafts, poetry, music).
Recurrent Respiratory Papillomatosis (RRP) – Meta-analyses on the use of the HPV vaccine as adjuvant therapy.
Authors: Goon Peter , Sauzet Odile , Schuermann Matthias , Oppel Felix , Shao SenYao , Scholtz Lars-Uwe , Sudhoff Holger , Goerner Martin
Published: July 2022

Objectives and importance:Recurrent Respiratory Papillomatosis(RRP) is a rare disease with severe morbidity. Treatment is surgical. Prevailing viewpoint is that prophylactic HPV vaccines do not have therapeutic benefit due to their modus operandi. Studies on HPV vaccination alongside surgery were meta-analysed to test effect on burden of disease.MethodsDatabases accessed Nov & Dec 2021[PubMed, Cochrane, Embase & Web of Science]. Main outcome measured: Mean paired differences in the number of surgeries or recurrences per month. Analyses: Random effect maximal likelihood estimation model using the Stata module Mataan(StataCorp. 2019. Stata Statistical Software: Release 16. College Station, TX:StataCorp LLC.)Resultsn=38 patients, suitable for syntheses with one previous meta-analyses(4 published, 2 unpublished studies)n=63, total of n=101 patients. Overall mean reduction of ≥8 recurrences compared to similar pre-vaccination period (95% CI [3.84, 10.98]) over 5 years. ConclusionsMeta-analyses favours HPV vaccine as adjunct therapy alongside surgery Trial registration: PROSPERO (awaiting number)
pH-responsive Cellulose Nanomaterial Films Containing Anthocyanins for Intelligent and Active Food Packaging Applications
Authors: Shayan Mohammad , Gwon Jaegyoung , Koo Meen S , Lee Danbee , Adhikari Achyut , Wu Qinglin
Published: July 2022

A combination of cellulose nanocrystals (CNCs) and nano-fibrillated cellulose (NFC) was used as a sustainable substrate to immobilize anthocyanins in red cabbage extract (RCE) and prepare a pH-sensitive packaging film. The incorporation of RCE in the CNC/NFC suspension changed the morphology and increased the steady-state viscosity and storage modulus of the suspension. Three rheological models (i.e., Power-law, Herschel-Bulkley, and Nasiri-Ashrafizadeh) fitted the relationship between shear stress and shear rate for each suspension. The incorporation of RCE to the CNC/NFC suspension altered the physical, optical, and mechanical properties of the films and acted as a free radical scavenger. The incorporation of 50 wt.% RCE in the CNC/NFC film enhanced its elongation at break by around 855%. With the enhanced film flexibility, its tensile strength, however, declined. The developed indicator film contained 30 wt.% RCE demonstrated an optimum physical, mechanical, and optical properties with the lowest response time to alkaline pH, which has a great potential as a pH-sensitive film for use in the seafood packaging industry.