bluuebunny/crossref_metadata_2025 huggingface dataset:
ChemInform Abstract: Iodocyclization of 1,4‐Dihydropyridines.
Authors: LAVILLA R. , COLL O. , NICOLAS M. , BOSCH J.
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Novel Approach to Isoindole[2,1‐a]quinolines.
Authors: PIGEON P. , DECROIX B.
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Syntheses of Thieno[2,3‐d]pyrimidines and Aminopyrimidines from 2‐Alkoxy‐5‐cyano‐4‐thioxopyrimidine Intermediates.
Authors: REHWALD M. , GEWALD K.
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Search for α1‐Adrenoceptor Subtypes Selective Antagonists: Design, Synthesis and Biological Activity of Cystazosin, an α1D‐Adrenoceptor Antagonist.
Authors: MINARINI A. , BUDRIESI R. , CHIARINI A. , LEONARDI A. , MELCHIORRE C.
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Studies on Activated Nitriles: Synthesis of New 3‐Cyano‐(p‐antipyrylamino)pyrazolo[1,5‐a]pyrimidines and Pyrazolo[1,5‐a]triazines.
Authors: FATHALLA O. A. , ZAKI M. E. A.
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Formation and Hetero Diels—Alder Reaction of α‐Iminosulfines: Synthesis of 5,6‐Dihydro‐1,4‐thiazine S‐Oxides.
Authors: CAPOZZI G. , MENICHETTI S. , NATIVI C. , VERGAMINI C.
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Pyrrole‐Annulated Heterocyclic Systems. Synthesis of 2H‐Pyrrolo[3,4‐b][1,5]benzothiazepine 4,4‐Dioxide Derivatives.
Authors: DI SANTO R. , COSTI R. , MASSA S. , ARTICO M.
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Transfer of Alk‐1‐enyl Group from Boron to Boron: Preparation of B‐[(E)‐Alk‐1‐enyl]‐9‐borabicyclo[3.3.1]nonane.
Authors: HOSHI M. , SHIRAKAWA K. , ARASE A.
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Rearrangement of o‐(Chloromethyldimethylsilyl)phenylmethoxide: Evidence for an Apical Position of the Migrating Group in a Trigonal Bipyramid Intermediate.
Authors: HIJJI Y. M. , HUDRLIK P. F. , HUDRLIK A. M.
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Zwitterionic 1‐Phosphonioalkyl Dithiophosphinates.
Authors: BREITSAMETER F. , SCHROEDEL H.‐P. , SCHMIDPETER A.
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Bridgehead Diphosphines in the Bicyclo[3.3.3]undecane and Bicyclo[4.4.4]tetradecane Series: Synthesis, Structure and Properties.
Authors: ALDER R. W. , ELLIS D. D. , GLEITER R. , HARRIS C. J. , LANGE H. , ORPEN A. G. , READ D. , TAYLOR P. N.
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: 1,4‐Addition of a Terminal Phosphinidene Complex to [5]Metacyclophane.
Authors: VAN EIS M. J. , KOMEN C. M. D. , DE KANTER F. J. J. , DE WOLF W. H. , LAMMERTSMA K. , BICKELHAUPT F. , LUTZ M. , SPEK A. L.
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Intramolecular Pd Catalyzed Carbocyclization Reactions with Planar Chiral Arene Tricarbonyl Chromium Complexes.
Authors: CROUSSE B. , XU L.‐H. , BERNARDINELLI G. , KUENDIG E. P.
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Asymmetric Synthesis of Boc‐N‐methyl‐p‐benzoyl‐phenylalanine. Preparation of a Photoreactive Antagonist of Substance P.
Authors: KAROYAN P. , SAGAN S. , CLODIC G. , LAVIELLE S. , CHASSAING G.
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: An Improved Synthesis of β‐Perfluoroalkylated Analogues of β‐Alanine.
Authors: OZER M. S. , THIEBAUT S. , GERARDIN‐CHARBONNIER C. , SELVE C.
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of α,α‐Disubstituted‐α‐amino Acids by Double Nucleophilic Addition to Cyanohydrins.
Authors: CHARETTE A. B. , GAGNON A. , JANES M. , MELLON C.
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Fluorescent Properties of Model Chromophores of Tyrosine‐66 Substituted Mutants of Aequorea Green Fluorescent Protein (GFP).
Authors: KOJIMA S. , OHKAWA H. , HIRANO T. , MAKI S. , NIWA H. , OHASHI M. , INOUYE S. , TSUJI F. I.
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of Enantiomeric Diethyl (1R,2R)‐ and (1S,2R)‐1,2,3‐Trihydroxypropylphosphonates.
Authors: WROBLEWSKI A. E. , BALCERZAK K. B.
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Glycosynthases: Mutant Glycosidases for Oligosaccharide Synthesis.
Authors: MACKENZIE L. F. , WANG Q. , WARREN R. A. J. , WITHERS S. G.
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of Four Spacer‐Containing “Tetrasaccharides” That Represent Four Possible Repeating Units of the Capsular Polysaccharide of Streptococcus pneumoniae Type 6B.
Authors: THIJSSEN M.‐J. L. , BIJKERK M. H. G. , KAMERLING J. P. , VLIEGENTHART J. F. G.
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Structure of the O‐Specific Polysaccharide of Citrobacter freundii O3a,3b,1c.
Authors: KOCHAROVA N. A. , BORISOVA S. A. , ZATONSKY G. V. , SHASHKOV A. S. , KNIREL Y. A. , KHOLODKOVA E. V. , STANISKAVSKY E. S.
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of the Antitumor Alkaloid (+)‐Pancratistatin Using the β‐Azidonation Reaction via a Prochiral 4‐Arylcyclohexanone Derivative.
Authors: MAGNUS P. , SEBHAT I. K.
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Biochemical Studies on Natural Products. Part 4. The First Conversion of Camptothecin to (S)‐Mappicine by an Efficient Chemoenzymatic Method.
Authors: DAS B. , MADHUSUDHAN P. , KASHINATHAM A.
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Multigram Synthesis of Mevalonolactone‐d9 and Its Application to Stereochemical Analysis by 1H NMR of the Saturation Reaction in the Biosynthesis of the 2,3‐Di‐O‐phytanyl‐sn‐glycerol Core of the Archaeal Membrane Lipid.
Authors: EGUCHI T. , MORITA M. , KAKINUMA K.
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Novel D‐Ring Analogues of Podophyllotoxin as Potent Anticancer Agents.
Authors: SUBRAHMANYAM D. , RENUKA B. , RAO C. V. L. , SAGAR P. S. , DEEVI D. S. , BABU J. M. , VYAS K.
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Formation and Characterization of Lead Magnesium Niobate Synthesized from the Molten Salt of Potassium Chlorate.
Authors: WAN D. M. , WANG J. , NG S. C. , GAN L. M.
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Analysis of Nanotube Technology
Authors: HOFFSCHULZ H. , OTTO J. W. , EICKENBUSCH H.
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Magnetic Dissipation Force Microscopy Studies of Magnetic Materials
Authors: LIU Y. , GRUTTER P.
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Interpenetrating Nets: Ordered, Periodic Entanglement
Authors: BATTEN S. R. , ROBSON R.
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Recent Progress in the Synthesis and Reactions of Isothiochromans
Authors: XU Y.‐C.
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of Avenaciolide and Related Bislactones
Authors: MARTIN V. S. , RODRIGUEZ C. M. , MARTIN T.
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: New Aspects of Catalytic Asymmetric Cyclopropanation
Authors: DOYLE M. P. , PROTOPOPOVA M. N.
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Organozinc Mediated Reactions
Authors: KNOCHEL P. , ALMENA PEREA J. J. , JONES P.
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Reactions of Thiocyanogen and Thiocyanogen Halides with Unsaturated Compounds
Authors: SKOROBOGATOVA E. V. , KARTASHOV V. R.
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Measurements of Relaxation Rates for Low Natural Abundance L = 1/2 Nuclei
Authors: KOWALEWSKI J. , MALER L.
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Advances in Flame‐Retarding Flexible Polyurethane Foam
Authors: ROSE R. S.
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Surface Science and the Silver‐Catalyzed Epoxidation of Ethylene: An Industrial Perspective
Authors: SERAFIN J. G. , LIU A. C. , SEYEDMONIR S. R.
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: The Super Fast Inversion Recovery (SUFIR) Experiment
Authors: CANET D. , MUTZENHARDT P. , ROBERT J.‐B.
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Des valeurs organisationnelles à la mobilisation des ressources humaines
Authors: Quenneville Nadine , Bentein Kathleen , Simard Gilles
Published: June 2010

This study examines the relationship of perceived organizational values to employee mobilization behaviours as mediated by perceived organizational support (POS) and affective organizational commitment. Firstly, a scale comprising three types of perceived organizational values (interpersonal values, formal values, and individual well‐being‐centered values) was developed and validated using a sample of 580 employees. Secondly, the relationships among variables were examined using structural equations modeling on an independent sample of 260 employees. POS mediated the relationship between employees' perceptions that their organization values the individual well‐being of its members and their affective organizational commitment, which in turn mediated the relationship between POS and individual mobilization behaviours. The contributions of these findings to advancing scholarship and practice are discussed. Copyright © 2010 ASAC. Published by John Wiley & Sons, Ltd.
The Effect of Pulmonary Hypertension on Left Ventricular Diastolic Function in Chronic Obstructive Lung Disease: A Tissue Doppler Imaging and Right Cardiac Catheterization Study
Authors: Acikel Mahmut , Kose Nuri , Aribas Alpay , Kaynar Hasan , Sevimli Serdar , Gurlertop Yekta , Erol M.Kemal
Published: June 2010

Background

Pulmonary hypertension (PH) caused by chronic obstructive lung disease (COLD) essentially involves the right heart. Also left ventricular (LV) systolic and diastolic functions may be affected.

Objectives

The aim of this study was to investigate the effect of on LV diastolic function in patients with COLD.

Methods

A total of 47 patients with COLD and 20 controls were included in this study. All patients underwent Doppler echocardiography, tissue Doppler imaging examinations and right cardiac catheterization. The patients were divided into 2 subgroups according to mean pulmonary arterial pressure (mPAP): patients without PH (group1, n = 25) and with PH (group 2, n = 22). The following measurements were taken: peak velocity of early diastolic filling (E), peak late filling with atrial contraction (A), E/A ratio, deceleration time (DT) of E, isovolumic relaxation time (IVRT), early (Em) and late (Am) diastolic mitral lateral annulus velocity.

Results

Mitral E/A < 1 and Em < 8 cm/sec were higher in group 2 than in group 1 and the control group. There were significant correlations between mPAP and both mitral E/A (r:− 0.60) and Em (r:− 0.45). In multivariate model, mPAP was not found to be significant on mitral E/A ratio < 1, but there was a significant effect on mitral Em < 8 cm/sec (odds ratio [OR]:1.14, P < 0.05).

Conclusion

This study shows that LV diastolic dysfunction in COLD is closely correlated to PH levels. Although increased mPAP may affect the mitral E/A ratio, it seems to have no effect on mitral E/A < 1, whereas it has an independent effect on Em < 8 cm/sec. Copyright © 2010 Wiley Periodicals, Inc.
Improved survival is associated with treatment at high‐volume teaching facilities for patients with advanced stage laryngeal cancer
Authors: Chen Amy Y. , Fedewa Stacey , Pavluck Alex , Ward Elizabeth M.
Published: June 2010

BACKGROUND:

Because of the multidisciplinary nature of treatment for advanced laryngeal cancer, the authors hypothesized that treatment at high‐volume teaching/research facilities is associated with improved survival.

METHODS:

After exclusions, 19,326 patients who were diagnosed with advanced laryngeal cancer (stage III and IV) between 1996 and 2002 and who received treatment (chemoradiotherapy [CRT], total laryngectomy [TL], or radiotherapy [RT]) were analyzed from the National Cancer Database (NCDB). Facilities were classified into 6 groups (low‐volume and high‐volume teaching/research facilities, low‐volume and high‐volume community cancer centers, and low‐volume and high‐volume community facilities). Multivariate proportional hazards regression modeling was used to determine 90‐day, 365‐day, and 4‐year hazard ratio (HR) estimates.

RESULTS:

Treatment included TL (37.6%), CRT (29.4%), and RT alone (33%). Overall, 36.2% of patients were treated at high‐volume teaching/research centers (average, 17.1 cases per year). Among all patients, 20% died within the first year. In multivariate models that were controlled for covariates, 90‐day, 365‐day, and 4 year HR estimates for death were lowest for high‐volume teaching/research centers.

CONCLUSIONS:

Receiving treatment at high‐volume teaching/research facilities was associated with improved survival. Undergoing total laryngectomy also was associated with improved survival. The current results suggested that the regionalization of care for patients with advanced‐stage laryngeal cancer has occurred, because most patients were treated either at high‐volume teaching/research facilities or at high‐volume community cancer centers. Future studies should investigate the factors associated with better survival at high‐volume teaching/research facilities, such as quality of care, processes of care, and referral patterns. Cancer 2010. © 2010 American Cancer Society.
Dose escalation of gemcitabine concomitant with radiation and cisplatin for nonsmall cell lung cancer
Authors: Momm Felix , Kaden Markus , Tannock Ian , Schumacher Martin , Hasse Joachim , Henke Michael
Published: June 2010

BACKGROUND:

The current study was conducted to evaluate the maximum tolerable dose of weekly gemcitabine administered simultaneously with radiation and cisplatin in patients with locally advanced nonsmall cell lung cancer (NSCLC).

METHODS:

Patients with stage IIIA/B NSCLC received concurrently 63 grays radiation and 20 mg/m2 cisplatin Day 1 to 3 in Weeks 1 and 5, plus weekly gemcitabine at escalating doses (150‐700 mg/m2) on Fridays after radiation to avoid radiosensitization. The authors assessed dose‐limiting toxicities according to Common Toxicity Criteria. The primary endpoint was maximum tolerated dose (MTD) of gemcitabine. Tumor resectability, survival, and disease‐free survival (DFS) were also determined.

RESULTS:

Forty‐two patients were accrued, of whom 95% received radiation and 66% cisplatin as above. Weekly doses of gemcitabine were escalated to 700 mg/m2. Grade 3 dysphagia and 1 case of fatal, probably treatment‐related pulmonary deterioration established the MTD of gemcitabine at 550 mg/m2 weekly. Twenty‐five patients underwent surgery, and histopathological complete regression was documented in 26% of these patients. Overall, median actuarial survival and DFS were 23.8 and 12.4 months, respectively.

CONCLUSIONS:

Gemcitabine at doses up to 550 mg/m2 weekly can be given simultaneously with radiation and cisplatin to patients with locally advanced NSCLC. Radical resection thereafter is feasible. The impact of this aggressive therapy should be evaluated further. Cancer 2010. © 2010 American Cancer Society.
Factors associated with low screening for breast cancer in the Palestinian authority
Authors: Azaiza Faisal , Cohen Miri , Awad Mariam , Daoud Francoise
Published: June 2010

BACKGROUND:

The current study was conducted to assess screening behaviors in relation to cultural and environmental barriers among Palestinian women in the West Bank.

METHODS:

The participants were 397 women, ages 30 to 65 years, residing in the Palestinian Authority, and a stratified sample method was used (98.3% participation rate). The participants completed questionnaires on breast examination behaviors and knowledge, on perceived cancer fatalism and health beliefs, and on environmental barriers scales.

RESULTS:

Greater than 70% of the women had never undergone mammography or clinical breast examination (CBE), whereas 62% performed self breast examination (SBE). Women were more likely to undergo mammography if they were less religious (odds ratio [OR], 0.59; 95% confidence interval [95% CI], 0.47‐0.81) and if they expressed lower personal barriers (OR, 0.59; 95% CI, 0.29‐0.76) and lower fatalism (OR, 0.39; 95% CI, 0.28‐0.63). A higher likelihood for CBE was related to being Christian (OR, 2.91; 95% CI, 1.49‐5.73) and being less religious (OR, 0.32; 95% CI, 0.13‐0.78), to perceived higher effectiveness of CBE (OR, 1.46; 95% CI, 1.20‐1.79), and to perceived lower cancer fatalism (OR, 0.35; 95% CI, 0.28‐0.60). Women were more likely to perform SBE if they were more educated, resided in cities, were Christian, were less religious, had a first‐degree relative with breast cancer, perceived higher effectiveness and benefits of SBE, and perceived lower barriers and fatalism.

CONCLUSIONS:

Participants reported a combination of personal, cultural, and environmental barriers, which should be addressed by educational programs and followed by the allocation of resources for early detection and treatment of breast cancer. Cancer 2010. © 2010 American Cancer Society.
Electronic Properties of Propylamine‐Functionalized Single‐Walled Carbon Nanotubes
Authors: Müller Matthias , Meinke Reinhard , Maultzsch Janina , Syrgiannis Zois , Hauke Frank , Pekker Áron , Kamarás Katalin , Hirsch Andreas , Thomsen Christian
Published: June 2010

We present resonant Raman measurements on single‐walled carbon nanotubes (SWCNT) functionalized with propylamine groups at different degrees. Direct nucleophilic addition based on in situ generated primary amides is used for attaching n‐propylamine to the sidewalls of SWCNTs. The influence of the amino functionalities on the electronic structure of the nanotubes is investigated. From the Raman resonance profiles of the radial breathing modes (RBMs), the chiral indices of the corresponding tubes are assigned. We observe significant redshifts of the transition energies and a broadening of the resonance windows due to chemical modification of SWCNTs. Similar redshifts are derived from the analysis of the NIR/Vis transmission spectrum. The relative Raman intensities of the functionalized samples and the evaluation of their transmission spectra indicate a diameter dependence of the reactivity as it has been observed for other moieties. By analyzing the defect induced D mode we observe a considerable degree of functionalization accompanied by an almost unharmed tube structure, which ensures that the observed effects are mainly driven by changes of the electronic structure.
Network structure of projections extending from peripheral neurons in the tunic of ascidian larva
Authors: Terakubo Hiroshi Q. , Nakajima Yoko , Sasakura Yasunori , Horie Takeo , Konno Alu , Takahashi Hiroki , Inaba Kazuo , Hotta Kohji , Oka Kotaro
Published: June 2010

In ascidian Ciona intestinalis, a subset of trunk epidermal neurons were shown to possess external network of neural projections. To characterize a more complete network in naturally hatched (chorionated) larvae, we visualized the structure with a confocal laser scanning microscope. High resolution images revealed the huge network consisting of several subnetworks in whole‐larval tunic. We named this network the ASNET (ascidian dendritic network in tunic). The ASNET was dynamically generated and collapsed during larval stages. Interestingly, one of the subnetworks found around apical trunk epidermal neurons was bilaterally asymmetric. In caudal epidermal neurons, transmission electron microscopy revealed that 9+2 axonemes were accompanied by a vesicle‐containing mass in the ASNET arbor, but the distal end of the arbor contained only the vesicle‐containing fibrous mass and no 9+2 axonemes. The characteristics of the ASNET suggest that it forms a unique outer body network in the ascidian larval tunic. Developmental Dynamics 239:2278–2287, 2010.© 2010 Wiley‐Liss, Inc.
Quantum Chemical Design for Enhanced Second‐Order NLO Response of Terpyridine‐Substituted Hexamolybdates
Authors: Janjua Muhammad Ramzan Saeed Ashraf , Guan Wei , Yan Likai , Su Zhong‐Min , Karim Abdul , Akbar Jamshed
Published: June 2010

A dramatic increase in the second‐order nonlinear optical (NLO) response of terpyridine‐substituted hexamolybdates has been observed from 886.55 × 10–30 esu (system 1) to 4622.92 × 10–30 esu (system 7). The dipole polarizabilities and second‐order nonlinear optical (NLO) properties of terpyridine derivatives of hexamolybdates have been investigated by using time‐dependent density functional theory (TDDFT). The quantum mechanical design suggests that [Mo6O18(N4C25H14(CF3)2 (CN)2)]2– (system 7) is the best choice among all studied systems to improve nonlinearity. The electron‐withdrawing ability of electron‐acceptor groups (F, Cl, Br, I, CF3, and CN) at the end of the terpyridine ligand directs the charge transfer (CT) from the POM cluster to the terpyridine segment along the z axis, which leads to an efficient second‐order NLO molecular design. These small changes in molecular composition by substitution may have disproportionately huge effects on the NLO properties, which can be attributed to the so‐called “butterfly effect”.
Orthogonal Regioselective Synthesis of N‐Alkyl‐3‐substituted Tetrahydroindazolones (Eur. J. Org. Chem. 20/2010)
Authors: Kim Jonghoon , Song Heebum , Park Seung Bum
Published: June 2010

The cover picture shows that the logical introduction of three reaction components can lead to the magical control of regiochemistry in biologically important N‐alkyl‐3‐substituted tetrahydroindazolones. This divergent strategy allows the robust and orthogonal regioselective synthesis of highly functionalized tetrahydroindazolones from Boc‐protected alkylhydrazines. Details are discussed in the article by S. B. Park et al. on p. 3815 ff. This paper is dedicated to the late Professor Chi Sun Hahn in admiration of his contributions to the field of organic chemistry in Korea.
Optimized sample preparation of endoscopic collected pancreatic fluid for SDS‐PAGE analysis
Authors: Paulo Joao A. , Lee Linda S. , Wu Bechien , Repas Kathryn , Banks Peter A. , Conwell Darwin L. , Steen Hanno
Published: June 2010

The standardization of methods for human body fluid protein isolation is a critical initial step for proteomic analyses aimed to discover clinically relevant biomarkers. Several caveats have hindered pancreatic fluid proteomics, including the heterogeneity of samples and protein degradation. We aim to optimize sample handling of pancreatic fluid that has been collected using a safe and effective endoscopic collection method (endoscopic pancreatic function test). Using SDS‐PAGE protein profiling, we investigate (i) precipitation techniques to maximize protein extraction, (ii) auto‐digestion of pancreatic fluid following prolonged exposure to a range of temperatures, (iii) effects of multiple freeze–thaw cycles on protein stability, and (iv) the utility of protease inhibitors. Our experiments revealed that TCA precipitation resulted in the most efficient extraction of protein from pancreatic fluid of the eight methods we investigated. In addition, our data reveal that although auto‐digestion of proteins is prevalent at 23 and 37°C, incubation on ice significantly slows such degradation. Similarly, when the sample is maintained on ice, proteolysis is minimal during multiple freeze–thaw cycles. We have also determined the addition of protease inhibitors to be assay‐dependent. Our optimized sample preparation strategy can be applied to future proteomic analyses of pancreatic fluid.
Electrophoretically mediated microanalysis for the evaluation of interspecies variation in cholinesterase metabolism
Authors: Moura Joana , Simplício Ana Luísa
Published: June 2010

This study describes an electrophoretically mediated microanalysis method, suitable for the preclinical evaluation of the hydrolysis of ester drugs by the serum of different animals and for further characterization of human–animal correlation. Dog, cat, cow, horse, sheep, rat and human serum were diluted (25%) in the appropriate buffer and replaced the enzyme solution usually used in electrophoretically mediated microanalysis methods for the study of enzyme kinetics. They were then compared in terms of the ability to hydrolyze acetylthiocholine and butyrylthiocholine (0.25 mM) by in‐capillary reaction. Human serum afforded the highest conversion rates (52% butyryltiocholine and 34% acetylthiocholine) followed by horse (31 and 35%), dog (26 and 24%), cat (22 and 14%), rat (11 and 15%) and sheep (8 and 8%). Hydrolysis by bovine serum was negligible. The method is fast (under 8 min including rinsing steps), sensitive (under 25 μM substrate could be quantified) and repeatable (RSD≈2%), only requiring minute amounts of sample.
The enhancement of distribution reactive power compensation in Taipower with immune algorithm
Authors: Kang M. S. , Chen C. S. , Lin C. H. , Wu J. D.
Published: June 2010

This paper presents an optimal capacitor planning strategy by considering the reactive load duration curves of distribution feeders to reduce system power loss and enhance reactive power compensation in Taipower. The objective function is formulated by including feeder peak power loss, annual energy loss and investment cost of capacitors with discrete capacities. In the proposed method, the immune algorithm (IA) is applied to solve the optimization problem and to derive the optimal sizes and locations of capacitors to be installed along the feeders by representing the objective function and constraints as antigens. The affinity calculation is embedded in the solution process to guarantee the diversity and prevent the stagnation of local sub‐optimality. After performing the genetic evolution, an antibody which fits the antigen best is determined to be the optimal capacitor planning. The three‐phase load flow analysis is executed by considering time‐varying load characteristic of customers to solve system power loss on annual basis with various capacitor‐planning scenarios. The marginal cost benefit (MCB) of the reactive power compensation is applied to solve the timings for the switched‐type capacitors. A practical distribution feeder is selected for computer simulation to demonstrate the effectiveness of the proposed IA methodology to solve the capacitor planning by evaluating the yearly peak power loss and total energy loss over the life cycle of capacitor investment. Copyright © 2010 John Wiley & Sons, Ltd.
Empirical assessment of strategic behavior in the Italian power exchange
Authors: Perekhodtsev Dmitri , Baselice Rossella
Published: June 2010

In this paper we examine the bidding behavior of Enel in 2004 to estimate the extent to which Enel was bidding opportunistically in temporal and geographic markets in which it was indispensible. Two types of competitive benchmark for bid levels were used. First, bids submitted by Enel in temporal and geographic markets in which it was pivotal were compared with Enel's bids submitted for similar generating units in markets where potential for market power exercise is low. Second, price bids of Enel were compared with bids submitted for comparable plants by other small generators that have no market power. This analysis has shown that over the period from April to August 2004 the bidding behavior of Enel varied across plant types. Both competitive benchmarks suggest that price bids of Enel submitted for Combined Cycle Gas plants were about 40–50% above the competitive level when Enel was pivotal. The excessive bidding was also present for Traditional Oil plants and Repowered Gas plants, although at a lower level, and was not established at all for Traditional Coal plants. We have verified whether this conduct could have had a material impact on market prices. An analysis of impact suggests that Enel's bidding during the peak hours was indeed 40% in excess of competitive levels for its CCGT units, 30% on Repowering units, and 20% on Oil units, such bidding have resulted in 20–30% higher average peak energy prices (PUN) in Italy. Copyright © 2010 John Wiley & Sons, Ltd.
Immersed boundary conditions method for heat conduction problems in slots with time‐dependent geometry
Authors: Del Rey Fernandez D. C. , Husain S. Z. , Floryan J. M.
Published: June 2010

A grid‐less, fully implicit, spectrally accurate algorithm for solving three‐dimensional, both stationary and time‐dependent, heat conduction problems in slots formed by either fixed or time‐dependent boundaries has been developed. The algorithm is based on the concept of immersed boundary conditions (IBC), where the physical domain is immersed within the computational domain and the boundary conditions take the form of internal constraints. The IBC method avoids the need to construct adaptive, time‐dependent grids resulting in the reduction of the required computational resources and, at the same time, maintaining accurate information about the location of the boundaries. The algorithm is spectrally accurate in space and capable of delivering first‐, second‐, third‐ and fourth‐order accuracy in time. Given a potentially large size of the resultant linear algebraic system, various methods that take advantage of the special structure of the coefficient matrix have been explored in search for an efficient solver, including a specialized direct solver as well as serial and parallel iterative solvers. The specialized direct solver has been found to be the most efficient from the viewpoints of the speed of the computations and the memory requirements. Copyright © 2010 John Wiley & Sons, Ltd.
Modeling two‐fluid response of thin elastic shells
Authors: Iakovlev S. , Mitchell M. , Dooley G.
Published: June 2010

The interaction between a weak external shock wave and a thin elastic cylindrical shell filled with and submerged into fluids with different properties is considered. The interest in investigating such a system is largely driven by the need for an accurate assessment of the performance of a number of industrial systems in extreme conditions of operations, with offshore, chemical, aerospace and nuclear industries being examples. The interaction is simulated using a semi‐analytical approach based on combining the analytical techniques of mathematical physics with finite‐difference approximations, and a number of effects of practical interest are observed, some for the first time. Specifically, it is demonstrated that four different interaction scenarios are possible, depending on the ratio of the acoustic speeds in the internal and external fluids, ζ. The case of ζ=1 is the previously addressed scenario of two identical fluids. When ζ>1, the situation changes dramatically because the internal pressure wave propagates faster than the external one, and as a result, not one but two high‐magnitude wavefronts are observed in the external fluid. The case of ζ<1 is even more interesting, with the possibility of two sub‐scenarios: one where the classical ‘reflection‐focusing’ sequence is observed inside the shell, and one where not one but two focusings are seen, one before and one after the reflection of the internal wave from the shell surface. The effect of placing rigid co‐axial cores of various radii inside the shell on the hydrodynamic fields is discussed as well. Copyright © 2010 John Wiley & Sons, Ltd.
Efficient Lagrangian scalar tracking method for reactive local mass transport simulation through porous media
Authors: Voronov Roman S. , VanGordon Samuel B. , Sikavitsas Vassilios I. , Papavassiliou Dimitrios V.
Published: June 2010

Mass transfer in the presence of chemical reactions for flows through porous media is of interest to many disciplines. The Lattice Boltzmann method (LBM) is particularly attractive in such cases due to the ease with which it handles complicated boundary conditions. However, useful Lagrangian information (such as solute survival distance, effective diffusivity, collision frequency) is challenging to obtain from the LBM. In this paper, we present a straightforward and efficient Lagrangian methodology (Lagrangian scalar tracking, LST) for performing solute transport simulations in the presence of heterogeneous, first‐order, irreversible reactions, based on a velocity field obtained from LBM. The hybrid LST/LBM technique tracks passive mass markers that have two contributions to their movement: convective (obtained through interpolation of a previously obtained velocity field) and Brownian. Various Schmidt number solutes and different solute release modes can be modeled with a single solvent flow field using this method. Moreover, the mass markers can have a range of reaction rate coefficients. This allows for the exploration of the whole spectrum of first‐order heterogeneous reaction rates with just a single simulation. In order to show the applicability of the LST/LBM scheme, results from a case study are presented in which the consumption of oxygen and/or nutrients within a porous bone tissue engineering scaffold is modeled under flow perfusion culturing conditions. Although the reactive LST methodology described in this paper compliments the LBM, it can also be used with any other flow simulation that can generate the velocity field. Copyright © 2010 John Wiley & Sons, Ltd.
Capped equity swaps under the double‐jump stochastic volatility model with stochastic interest rates
Authors: Guo Jia‐Hau
Published: June 2010

This study proposes a double‐jump stochastic volatility model with stochastic interest rates to price capped equity swaps and other multi‐period derivative securities. Closed‐form solutions for capped equity swaps with a fixed or variable notional principle are derived. In addition, numerical examples are employed to analyze comparative statics properties, counterparty risks, and the dynamics of the forward smile. © 2010 Wiley Periodicals, Inc. Jrl Fut Mark 31:340–370, 2011
Critical roles of LGN/GPSM2 phosphorylation by PBK/TOPK in cell division of breast cancer cells
Authors: Fukukawa Chikako , Ueda Koji , Nishidate Toshihiko , Katagiri Toyomasa , Nakamura Yusuke
Published: June 2010

To investigate the molecular mechanism of mammary carcinogenesis and identify novel molecular targets for breast cancer therapy, we analyzed genome‐wide gene expression profiles of 81 clinical breast cancer samples. Here, we report the critical role of LGN/GPSM2 (Leu‐Gly‐Asn repeat‐enriched protein/G‐protein signaling modulator 2) in the growth of breast cancer cells. Semiquantitative RT‐PCR and Northern blot analyses confirmed upregulation of LGN/GPSM2 in a large proportion of breast cancers. Immunocytochemical staining identified LGN/GPSM2 at the spindle in cells at metaphase, and at midzone and midbody in cytokinetic cells. Western blot analysis indicated the highest expression and the phosphorylated form of LGN/GPSM2 protein in G2/M phase. Treatment with small‐interfering RNAs (siRNAs) targeting LGN/GPSM2 caused incompletion of cell division and resulted in significant growth suppression of breast cancer cells. We found that the 450th threonine (Thr450) of LGN/GPSM2 was phosphorylated by the serine/threonine kinase PBK/TOPK during mitosis. Overexpression of LGN/GPSM2‐T450A in which Thr450 was substituted with alanine induced growth suppression and aberrant chromosomal segregation. These findings imply an important role of LGN/GPSM2 in cell division of breast cancer cells and suggest that the PBK/TOPK‐LGN/GPSM2 pathway might be a promising molecular target for treatment of breast cancer. © 2010 Wiley‐Liss, Inc.
Acute leukemias with ETV6/ABL1 (TEL/ABL) fusion: Poor prognosis and prenatal origin
Authors: Zuna Jan , Zaliova Marketa , Muzikova Katerina , Meyer Claus , Lizcova Libuse , Zemanova Zuzana , Brezinova Jana , Votava Felix , Marschalek Rolf , Stary Jan , Trka Jan
Published: June 2010

The ETV6/ABL1 (TEL/ABL) fusion gene is a rare aberration in malignant disorders. Only 19 cases of ETV6/ABL1‐positive hematological malignancy have been published, diagnosed with chronic myeloid leukemia, other types of chronic myeloproliferative neoplasm, acute myeloid leukemia or acute lymphoblastic leukemia (ALL). This study reports three new cases (aged 8 months, 5 years, and 33 years) of ALL with the ETV6/ABL1 fusion found by screening 392 newly diagnosed ALL patients (335 children and 57 adults). A thorough review of the literature and an analysis of all published data, including the three new cases, suggest poor prognosis of ETV6/ABL1‐positive acute leukemias. The course of the disease in the two pediatric patients is characterized by minimal residual disease monitoring, using quantification of both the ETV6/ABL1 transcript and immunoreceptor gene rearrangements. Eosinophilia could not be confirmed as a hallmark of the ETV6/ABL1‐positive disease. Studies of neonatal blood spots demonstrated that, in the child diagnosed at five years, the ETV6/ABL1 fusion initiating the ALL originated prenatally. © 2010 Wiley‐Liss, Inc.