bluuebunny/crossref_metadata_2025 huggingface dataset:
Santripreneur: Menumbuhkan Embrio Pendidikan Wirausaha Berbasis Pesantren
Authors: Robbani Mochammad Burhanuddin , Pujianto Wahyu Eko
Published: March 2024

Pada program pengembangan kewirausahaan unggulan yang berbasis sistem pesantren ini, tim menyelenggarakan pelatihan produksi batik. Tujuan utama dari pelatihan ini adalah untuk meningkatkan produksi dan merangsang pertumbuhan ekonomi di Pondok Pesantren Roudlotul Muta'allim Wal Muta'allimat yang terletak di Kota Sidoarjo. Pendampingan Santri dianggap penting dalam rangka meningkatkan kemandirian keuangan mereka. Lebih lanjut, klaim tersebut diperkuat lagi dengan penelitian yang dilakukan oleh PP. Roudlotul Muta'allimin Wal Muta'allimat di Kota Sidoarjo yang memungkinkan para santri menjadi wirausahawan untuk memulai santri mandiri secara finansial. Melalui program bakti yang saya selenggarakan dan bekerjasama dengan Pengusaha Batik di Kedungcangkring ini, saya sangat berharap akan lahir pengusaha-pengusaha baru dan pengusaha santri di bidang keuangan yang dapat menjalankan usahanya Untuk memperbaiki diri. Kegiatan ini disusun dalam lima tahapan yang berbeda, yaitu observasi, pemetaan program, penyuluhan, pelatihan, dan pendampingan.
Penerapan Open-Ended Question dalam Model Pembelajaran Problem Based Learning (PBL) terhadap Hasil Belajar Kognitif Siswa Kelas X IIS 2 SMAN 8 Mataram
Authors: Hasanah Miftahul , Khairuddin  , Rohayuni
Published: March 2024

Berdasarkan hasil observasi yang telah dilakukan, hasil belajar kognitif peserta didik di SMAN 8 Mataram pada mata pelajaran Biologi masih belum mencapai Kriteria Ketuntasan Minimum (KKM).  Sehingga dilakukan penelitian yang bertujuan untuk mendeskripsikan penerapan open-ended question dalam model pembelajaran Problame Based Learning (PBL) terhadap hasil belajar kognitif pada materi ekosistem kelas X IIS 2 SMAN 8 Mataram. Subyek penelitian berjumlah 30 orang yang teridiri dari 14 laki-laki dan 16 perempuan. Pelaksanaan dilaksanakan menggunakan metode Lesson Study yang terdiri dari 2 siklus yaitu tahap perencanaan, pelaksanaan, dan refleksi. Data penelitian berupa hasil belajar kognitif yang diambil dengan teknik tes pilihan ganda dan essay. Hasil penelitian ini menunjukkan bahwa, pada siklus I nilai ketuntasan klasikal peserta didik 67% dengan nilai rata-rata kemampuan kognitif 74. Pada siklus II nilai ketuntasan klasikal peserta didik 83% dengan nilai rata-rata kemampuan kognitif 84. Hal ini menunjukkan bahwa penerapan Open-ended question dalam model pembelajaran PBL dapat meningkatkan hasil belajar peserta didik.
Efektivitas Pelatihan Public Speaking dalam Meningkatkan Kemampuan Mahasiswa Berbicara di Depan Umum
Authors: Muchlis Lulu Nazma Lailatul , Pujianto Wahyu Eko
Published: March 2024

Abstrak

Meningkatkan soft skill mahasiswa merupakan investasi yang layak dilakukan di masa depan. Penelitian ini bertujuan untuk mengetahui efektivitas pelatihan public speaking yang dilaksanakan dalam meningkatkan keterampilan public speaking mahasiswa. Hasil penelitian menunjukkan bahwa pelatihan public speaking yang dilaksanakan efektif dalam meningkatkan keterampilan public speaking Mahasiswa. Hal ini ditunjukkan dengan meningkatnya kemampuan mahasiswa dalam menyampaikan ide, pemikiran atau informasi dengan baik, serta meningkatnya rasa percaya diri mahasiswa dalam berbicara di depan umum. Sebagai seseorang mahasiswa perlu untuk melakukan pengembangan diri dengan mengkuti pelatihan public speaking yang terdapat praktiknya, bukan hanya teori saja. Dengan memiliki public speaking yang baik, membuat seseorang mampu mengembangkan keterampilan berbicara dan meningkatkan kepercayaan diri. Hasil positif yang dicapai dalam menumbuhkan rasa percaya diri dan membentuk generasi berkarakter kuat menunjukkan potensi pengembangan lebih lanjut dan optimalisasi program pelatihan public speaking ini.
Peran Organisasi Mahasiswa Dalam Pembentukan Sikap Demokratis (Studi Kasus pada Organisasi HIMAMASDA)
Authors: Astutik Aisya Ayuni , Pujianto Wahyu Eko
Published: March 2024

Abstrak Tujuan dari penelitian ini adalah untuk memastikan bagaimana peran organisasi mahasiswa dalam pembentukan sikap demokratis. Sikap demokrasi didasarkan pada pengembangan pandangan demokrasi mahasiswa. peran organisasi mahasiswa HIMAMASDA berkontribusi terhadap pembentukan sikap demokrastis dalam mendidik mahasiswa tentang nilai demokrasi dalam menjaga eksistensi bangsa. Dalam penelitian ini menggunakan metodologi penelitian deskriptif kualitatif. Penelitian yang mencirikan atau menggambarkan item penelitian berdasarkan fakta yang nyata atau yang sebenarnya disebut penelitian deskriptif kualitatif. Hasil penelitian ini adalah 1) bagaimana membentuk sikap demokratis melalui fungsi organisasi HIMAMASDA melalui musyawarah seluruh anggota organisasi mahasiswa. 2) Hambatan yang dirasakan oleh pengurus HIMAMASDA adalah masih adanya keterbatasan dana dalam melaksanakan kegiatan-kegiatan kemahasiswaan. 3) Penyelesaian hambatan memerlukan pelaksanaan penilaian rutin untuk mengukur efektivitas program yang telah ditetapkan dan, jika diperlukan, menerapkan langkah-langkah perbaikan. Hal ini akan menjamin bahwa program dilaksanakan sesuai rencana dan mencapai tujuan yang dimaksudkan.
Peningkatan Kinerja Organisasi untuk Menciptakan Kepemimpinan Tranformasional Melalui Ujian Kenaikan Tingkat Pada Organisasi Pencak Silat Nahdlatul Ulama Pagar Nusa PAC Candi
Authors: Nisa Khoirun , Pujianto Wahyu Eko
Published: March 2024

Ujian kenaikan tingkat pada organisasi pencak silat Nahdlatul Ulama Pagar Nusa PAC Candi merupakan salah satu sarana untuk menciptakan kepemimpinan transformasional. Ujian ini bertujuan untuk mengukur tingkat kemampuan dan kematangan anggota organisasi, serta membentuk jiwa kepemimpinan yang tangguh. Adapun sasaran dari ujian tingkat ini yaitu anggota Pencak Silat Nahdlatul Ulama Pagar Nusa PAC Candi. Ujian tingkat ini dimulai dari UPS (Ujian Pengambilan Sabuk), lalu UKT (Ujian Kenaikan Tingkat) dari polos ke putih, dari putih ke kuning, dari kuning ke merah, dari merah ke biru, dari biru ke coklat, dan terakhir dari coklat ke hitam. Tentunya setiap tingkat memiliki tingkat kesulitan yang berbeda. Ujian yang dilakukan yaitu ujian tulis, ujian lisa, ujian fisik & mental, hafalan jurus, dan kegiatan keagamaan lainnya seperti tahlil dan mengaji serta materi kebangsaan, NU, dan Pagar Nusa. Berdasarkan hasil penelitian tersebut, dapat disimpulkan bahwa ujian kenaikan tingkat merupakan sarana yang efektif untuk meningkatkan kinerja organisasi dan menciptakan kepemimpinan transformasional. Peningkatan kinerja organisasi ini disebabkan oleh beberapa faktor, yaitu ujian kenaikan tingkat yang memiliki tingkat kesulitan berbeda-beda yang dapat mengukur tingkat kemampuan dan kematangan anggota organisasi. Penyampaian materi organisasi tentang aswaja dan wawasan kebangsaan juga dapat meningkatkan pengetahuan dan pemahaman anggota organisasi. Proses ujian yang melibatkan berbagai aspek seperti fisik, teknik, mental, dan spiritual, yang dapat membentuk anggota menjadi pribadi yang tangguh dan memiliki jiwa kepemimpinan.
Chernobyl as Pandemic Practice
Authors: Olsen Mulle
Published: March 2024

This article seeks to explain the appeal of the HBO miniseries Chernobyl during the COVID-19 pandemic by using simulation theory and morbid curiosity. Chernobyl’s main appeal is that it offers viewers a better source of negative emotions compared to the nebulous anxiety caused by the pandemic. Chernobyl achieves this by simulating a threat with certain similarities to a virus but which is made less unknown and, in turn, less anxiety-inducing. The threat is made less unknown mainly through the use of visual and auditory threat cues. Furthermore, morbid imagery and information appeal to morbidly curious viewers by providing salient knowledge about the effects of an invisible, airborne threat on the human body. The inclusion of authentic phone calls and a newscast further adds to the morbid appeal of the miniseries. Lastly, the fact that Chernobyl aired just before the pandemic in an increasingly post-truth world only made it more relevant.
Comparing Comparatives
Authors: Katballe-Kristensen Peter
Published: March 2024

This article explores the acceptability of constructions with double comparative elements in Danish and English. First, a brief introduction to theoretical assumptions for adjective phrases and degree phrases is given. After this, the methodology and challenges of setting up an empirical study are laid out. The results of the acceptability study were that native speakers of Danish and English evaluated double comparative constructions as being rather unacceptable when compared with control sentences and standard comparative constructions.
Somatotopic organization among parallel sensory pathways that promote a grooming sequence in Drosophila
Authors: Eichler Katharina , Hampel Stefanie , Alejandro-García Adrián , Calle-Schuler Steven A. , Santana-Cruz Alexis , Kmecova Lucia , Blagburn Jonathan M. , Hoopfer Eric D. , Seeds Andrew M.
Published: March 2024

Mechanosensory neurons located across the body surface respond to tactile stimuli and elicit diverse behavioral responses, from relatively simple stimulus location-aimed movements to complex movement sequences. How mechanosensory neurons and their postsynaptic circuits influence such diverse behaviors remains unclear. We previously discovered that
Drosophila
perform a body location-prioritized grooming sequence when mechanosensory neurons at different locations on the head and body are simultaneously stimulated by dust (Hampel et al., 2017; Seeds et al., 2014). Here, we identify nearly all mechanosensory neurons on the
Drosophila
head that individually elicit aimed grooming of specific head locations, while collectively eliciting a whole head grooming sequence. Different tracing methods were used to reconstruct the projections of these neurons from different locations on the head to their distinct arborizations in the brain. This provides the first synaptic resolution somatotopic map of a head, and defines the parallel-projecting mechanosensory pathways that elicit head grooming.
A versatile high-throughput assay based on 3D ring-shaped cardiac tissues generated from human induced pluripotent stem cell derived cardiomyocytes
Authors: Seguret Magali , Davidson Patricia , Robben Stijn , Jouve Charlène , Pereira Céline , Lelong Quitterie , Deshayes Lucille , Cerveau Cyril , Le Berre Maël , Rodrigues Ribeiro Rita S. , Hulot Jean-Sébastien
Published: March 2024

We developed a 96-well plate assay which allows fast, reproducible and high-throughput generation of 3D cardiac rings around a deformable optically transparent hydrogel (PEG) pillar of known stiffness. Human induced pluripotent stem cell-derived cardiomyocytes, mixed with normal human adult dermal fibroblasts in an optimized 3:1 ratio, self-organized to form ring-shaped cardiac constructs. Immunostaining showed that the fibroblasts form a basal layer in contact with the glass, stabilizing the muscular fiber above. Tissues started contracting around the pillar at D1 and their fractional shortening increased until D7, reaching a plateau at 25±1%, that was maintained up to 14 days. The average stress, calculated from the compaction of the central pillar during contractions, was 1.4±0.4 mN/mm2. The cardiac constructs recapitulated expected inotropic responses to calcium and various drugs (isoproterenol, verapamil) as well as the arrhythmogenic effects of dofetilide. This versatile high-throughput assay allows multiple in situ mechanical and structural read-outs.
Aging impairs cold-induced beige adipogenesis and adipocyte metabolic reprogramming
Authors: Holman Corey D. , Sakers Alexander P. , Calhoun Ryan P. , Cheng Lan , Fein Ethan C. , Jacobs Christopher , Tsai Linus , Rosen Evan D. , Seale Patrick
Published: March 2024

The energy-burning capability of beige adipose tissue is a potential therapeutic tool for reducing obesity and metabolic disease, but this capacity is decreased by aging. Here, we evaluate the impact of aging on the profile and activity of adipocyte stem and progenitor cells (ASPCs) and adipocytes during the beiging process. We found that aging increases the expression of
Cd9
and other fibro-inflammatory genes in fibroblastic ASPCs and blocks their differentiation into beige adipocytes. Fibroblastic ASPC populations from young and aged mice were equally competent for beige differentiation
in vitro
, suggesting that environmental factors suppress adipogenesis
in vivo
. Examination of adipocytes by single nucleus RNA-sequencing identified compositional and transcriptional differences in adipocyte populations with age and cold exposure. Notably, cold exposure induced an adipocyte population expressing high levels of
de novo
lipogenesis (DNL) genes, and this response was severely blunted in aged animals. We further identified natriuretic peptide clearance receptor
Npr3
, a beige fat repressor, as a marker gene for a subset of white adipocytes and an aging-upregulated gene in adipocytes. In summary, this study indicates that aging blocks beige adipogenesis and dysregulates adipocyte responses to cold exposure and provides a unique resource for identifying cold and aging-regulated pathways in adipose tissue.
Loss of Tumour Suppressor TMEM127 Drives RET-mediated Transformation Through Disrupted Membrane Dynamics
Authors: Walker Timothy J. , Reyes-Alvarez Eduardo , Hyndman Brandy D. , Sugiyama Michael G. , Oliveira Larissa C.B. , Rekab Aisha N. , Crupi Mathieu J.F. , Cabral-Dias Rebecca , Guo Qianjin , Dahia Patricia L.M. , Richardson Douglas S. , Antonescu Costin N. , Mulligan Lois M.
Published: March 2024

Internalization from the cell membrane and endosomal trafficking of receptor tyrosine kinases (RTK) are important regulators of signaling in normal cells that can frequently be disrupted in cancer. The adrenal tumour pheochromocytoma (PCC) can be caused by activating mutations of the RET receptor tyrosine kinase, or inactivation of TMEM127, a transmembrane tumour suppressor implicated in trafficking of endosomal cargos. However, the role of aberrant receptor trafficking in PCC is not well understood. Here, we show that loss of TMEM127 causes wildtype RET protein accumulation on the cell surface, where increased receptor density facilitates constitutive ligand-independent activity and downstream signaling, driving cell proliferation. Loss of TMEM127 altered normal cell membrane organization and recruitment and stabilization of membrane protein complexes, impaired assembly, and maturation of clathrin coated pits, and reduced internalization and degradation of cell surface RET. In addition to RTKs, TMEM127 depletion also promoted surface accumulation of several other transmembrane proteins, suggesting it may cause global defects in surface protein activity and function. Together, our data identify TMEM127 as an important determinant of membrane organization including membrane protein diffusability, and protein complex assembly and provide a novel paradigm for oncogenesis in PCC where altered membrane dynamics promotes cell surface accumulation and constitutive activity of growth factor receptors to drive aberrant signaling and promote transformation.
Multimodal mismatch responses in mouse auditory cortex
Authors: Solyga Magdalena , Keller Georg B.
Published: March 2024

Our movements result in predictable sensory feedback that is often multimodal. Based on deviations between predictions and actual sensory input, primary sensory areas of cortex have been shown to compute sensorimotor prediction errors. How prediction errors in one sensory modality influence the computation of prediction errors in another modality is still unclear. To investigate multimodal prediction errors in mouse auditory cortex (ACx), we used a virtual environment to experimentally couple running to both self-generated auditory and visual feedback. Using two-photon microscopy, we first characterized responses of layer 2/3 (L2/3) neurons to sounds, visual stimuli, and running onsets and found responses to all three stimuli. Probing responses evoked by audiomotor mismatches, we found that they closely resemble visuomotor mismatch responses in visual cortex (V1). Finally, testing for cross modal influence on audiomotor mismatch responses by coupling both sound amplitude and visual flow speed to the speed of running, we found that audiomotor mismatch responses were amplified when paired with concurrent visuomotor mismatches. Our results demonstrate that multimodal and non-hierarchical interactions shape prediction error responses in cortical L2/3.
Impact of the clinically approved BTK inhibitors on the conformation of full-length BTK and analysis of the development of BTK resistance mutations in chronic lymphocytic leukemia
Authors: Joseph Raji E. , Wales Thomas E. , Jayne Sandrine , Britton Robert G. , Fulton D. Bruce , Engen John R. , Dyer Martin J. S. , Andreotti Amy H.
Published: March 2024

Inhibition of Bruton’s tyrosine kinase (BTK) has proven to be highly effective in the treatment of B-cell malignancies such as chronic lymphocytic leukemia (CLL), autoimmune disorders and multiple sclerosis. Since the approval of the first BTK inhibitor (BTKi), Ibrutinib, several other inhibitors including Acalabrutinib, Zanubrutinib, Tirabrutinib and Pirtobrutinib have been clinically approved. All are covalent active site inhibitors, with the exception of the reversible active site inhibitor Pirtobrutinib. The large number of available inhibitors for the BTK target creates challenges in choosing the most appropriate BTKi for treatment. Side-by-side comparisons in CLL have shown that different inhibitors may differ in their treatment efficacy. Moreover, the nature of the resistance mutations that arise in patients appears to depend on the specific BTKi administered. We have previously shown that Ibrutinib binding to the kinase active site causes unanticipated long-range effects on the global conformation of BTK (Joseph, R.E., et al., 2020, https://doi.org/10.7554/eLife.60470). Here we show that binding of each of the five approved BTKi to the kinase active site brings about distinct allosteric changes that alter the conformational equilibrium of full-length BTK. Additionally, we provide an explanation for the resistance mutation bias observed in CLL patients treated with different BTKi and characterize the mechanism of action of two common resistance mutations: BTK T474I and L528W.
ACK1 and BRK non-receptor tyrosine kinase deficiencies are associated with familial systemic lupus and involved in efferocytosis
Authors: Guillet Stephanie , Lazarov Tomi , Jordan Natasha , Boisson Bertrand , Tello Maria , Craddock Barbara , Zhou Ting , Nishi Chihiro , Bareja Rohan , Yang Hairu , Rieux-Laucat Frederic , Fregel Lorenzo Rosa Irene , Dyall Sabrina D , Isenberg David , D'Cruz David , Lachmann Nico , Elemento Olivier , Viale Agnes , Socci Nicholas D , Abel Laurent , Nagata Shigekazu , Huse Morgan , Miller W Todd , Casanova Jean-Laurent , Geissmann Frédéric
Published: March 2024

Systemic lupus erythematosus (SLE) is an autoimmune disease, the pathophysiology and genetic basis of which are incompletely understood. Using a forward genetic screen in multiplex families with SLE, we identified an association between SLE and compound heterozygous deleterious variants in the non-receptor tyrosine kinases (NRTKs) ACK1 and BRK. Experimental blockade of ACK1 or BRK increased circulating autoantibodies in vivo in mice and exacerbated glomerular IgG deposits in an SLE mouse model. Mechanistically, NRTKs regulate activation, migration, and proliferation of immune cells. We found that the patients’ ACK1 and BRK variants impair efferocytosis, the MERTK-mediated anti-inflammatory response to apoptotic cells, in human induced pluripotent stem cell (hiPSC)-derived macrophages, which may contribute to SLE pathogenesis. Overall, our data suggest that ACK1 and BRK deficiencies are associated with human SLE and impair efferocytosis in macrophages.
ACK1 and BRK non-receptor tyrosine kinase deficiencies are associated with familial systemic lupus and involved in efferocytosis
Authors: Guillet Stephanie , Lazarov Tomi , Jordan Natasha , Boisson Bertrand , Tello Maria , Craddock Barbara , Zhou Ting , Nishi Chihiro , Bareja Rohan , Yang Hairu , Rieux-Laucat Frederic , Fregel Lorenzo Rosa Irene , Dyall Sabrina D. , Isenberg David , D’Cruz David , Lachmann Nico , Elemento Olivier , Viale Agnes , Socci Nicholas D. , Abel Laurent , Nagata Shigekazu , Huse Morgan , Miller W. Todd , Casanova Jean-Laurent , Geissmann Frederic
Published: March 2024

Systemic Lupus Erythematosus (SLE) is an autoimmune disease, the pathophysiology and genetic basis of which are incompletely understood. Non-receptor tyrosine kinases (NRTKs) regulate activation, migration, and proliferation of immune cells. We report compound heterozygous deleterious variants in the kinase domains of the non-receptor tyrosine kinases (NRTK) TNK2/ACK1 in one multiplex family and PTK6/BRK in another. Experimental blockade of mouse ACK1 or BRK increases glomerular IgG deposits and circulating autoantibodies in an
in vivo
SLE model. In addition, we found that the patients’ ACK and BRK variants impair efferocytosis, the MERTK-mediated anti-inflammatory response to apoptotic cells, in human induced Pluripotent Stem Cells (hiPSC)-derived macrophages. Overall, our data suggest that ACK1 and BRK deficiencies are associated with human SLE and impair efferocytosis.Human ACK1 and BRK kinases loss of function variants underlie systemic lupus erythematosus in young patients from multiplex families and disrupt the anti-inflammatory response of macrophages to apoptotic cells.
Full-length direct RNA sequencing uncovers stress-granule dependent RNA decay upon cellular stress
Authors: Dar Showkat A. , Malla Sulochan , Martinek Vlastimil , Payea Matthew J. , Lee Christopher T. , Martin Jessica , Khandeshi Aditya J. , Martindale Jennifer L. , Belair Cedric , Maragkakis Manolis
Published: March 2024

Cells react to stress by triggering response pathways, leading to extensive alterations in the transcriptome to restore cellular homeostasis. The role of RNA metabolism in shaping the cellular response to stress is vital, yet the global changes in RNA stability under these conditions remain unclear. In this work, we employ direct RNA sequencing with nanopores, enhanced by 5’ end adaptor ligation, to comprehensively interrogate the human transcriptome at single-molecule and nucleotide resolution. By developing a statistical framework to identify robust RNA length variations in nanopore data, we find that cellular stress induces prevalent 5’ end RNA decay that is coupled to translation and ribosome occupancy. Unlike typical RNA decay models in normal conditions, we show that stress-induced RNA decay is dependent on XRN1 but does not depend on removal of the poly(A) tail. We observed that RNAs undergoing decay are predominantly enriched in the stress granule transcriptome. Inhibition of stress granule formation via genetic ablation of G3BP1 and G3BP2 fully rescues RNA length and suppresses stress-induced decay. Our findings reveal RNA decay as a key determinant of RNA metabolism upon cellular stress and dependent on stress-granule formation.
Aplicação de lógica fuzzy na análise de eficiência de uma linha de soldagem para contribuir no processo de tomada de decisão
Authors: Farias Leandro da Mota , Guimarães Gil Eduardo , Marinelli Filho Nelson , Trevisol Janyel
Published: March 2024

No cenário atual do mercado, as empresas encontram um mercado altamente competitivo e desafiador devido a diversos fatores econômicos e tecnológicos. Empresas que não se modernizam são ultrapassadas por novas empresas que possuem metodologias de mercados mais ágeis e eficientes. Dessa forma, se uma empresa busca se manter no mercado, a mesma deve buscar aplicações de novas metodologias de mercado. As aplicações da Indústria 4.0 estão cada vez mais se difundindo no meio industrial através de diferentes ferramentas como: automação, IoT, entre outros. Empresas que utilizam essas ferramentas conseguem diminuir custos e se tornarem mais eficientes. Desta forma, cada vez mais se buscam implementar estas ferramentas no meio industrial. Este trabalho busca a aplicação de meios matemáticos como Lógica Fuzzy, para elaborar uma análise de KPI (Key Performace Indicator) para auxiliar no processo de decisão voltado para aumento de eficiência de uma linha de produção de soldagem de motocicletas em uma empresa localizado na Zona Franca de Manaus, Através destes meios matemáticos é possível visualizar pontos ótimos de processo, auxiliando aos gestores a terem uma visão mais clara quanto a questões muito imprecisas e que, muitas vezes, dependem do ponto de vista de quem está tomando a decisão. Utilizando-se de métodos como mapeamento do processo produtivo, levantamento de dados como tempo de processo, área do layout, fluxo produtivo, entre outros indicadores, elaborou-se uma análise utilizando Lógica Fuzzy buscando atender o ponto ótimo em pontos como espaço de layout, estoque de peças e eficiência da linha. Este trabalho visa detectar quais pontos são pontos de gargalo, e gerar oportunidades de desverticalização para oferecer uma proposta de melhoria produtiva, diminuindo as perdas e melhorando o fluxo de processo.
Redução do consumo de energia no processo de tratamento térmico T6 nas ligas de alumínio AC2B – AlCuSi
Authors: Silva Ricardo Cruz da , Guimarães Gil Eduardo , Marinelli Filho Nelson , Trevisol Janyel
Published: March 2024

O alumínio é o segundo metal mais produzido no mundo, atrás apenas do aço, mas em relação a quantidade de energia utilizada no processo de redução do minério de bauxita em alumina (Al2O3) por exigir temperaturas acima de 2000°C, torna o processo de beneficiamento muito mais oneroso em relação a custo e produção de CO2, contribuindo com a siderurgia mundial na geração de cerca de 6,5% na emissão de CO2 do mundo, ou 6,9 bilhões de toneladas de CO2/ano, onde 80% das emissões de gases do efeito estufa resultantes do consumo de energéticos, cerca de 1,36tCO2eq/t. No entanto, todo esforço da indústria na redução do consumo de energia e emissão de CO2 nesta etapa é limitada, devido a particularidade do processo de redução eletrolítica de Hall-Herolut no beneficiamento do minério de alumínio, o que torna a reciclagem o meio de maior viabilidade na redução destes índices. Uma outra possibilidade de obter-se redução no consumo de energia e emissão de CO2 seria nos processos subsequentes à produção do alumínio primário, através da redução de tempo e/ou temperaturas utilizadas nos processos de tratamentos térmicos aplicados em produtos de ligas de alumínio que necessitam de maior resistência, por meio da criação de novas ligas ou adequação de ligas tradicionais que há tempos são utilizadas nas industrias com parâmetros definidos que perderam a competividade mediante ao avanço do conhecimento cientifico, e uma destas ligas é da série 2xxx, liga de Al-Cu classificada nas normas internacionais como JIS AC2B ou SAE A319. Este trabalho tem por objetivo demonstrar a viabilização destas ligas tradicionais há décadas utilizadas no mercado nacional automobilístico a condições que favoreçam as reduções do consumo de energia elétrica e emissão CO2 durante os tratamentos térmicos através da determinação de novos limites dos elementos de liga Cu, Si e Mg.
Planejamento estratégico da biblioteca comunitária da UFSCar
Authors: Lazarin Daniel França , César Sheila Rizzo , Oliveira Mario Henrique da Fonseca , Sciuto Joseleine Maria
Published: March 2024

O planejamento estratégico é um importante instrumento de gestão para as organizações na atualidade. Constitui uma das mais importantes funções administrativas e é através dele que o gestor e sua equipe estabelecem os parâmetros que vão direcionar a organização da empresa. O objetivo do planejamento é fornecer aos gestores e suas equipes uma ferramenta que os municie de informações para a tomada de decisão, ajudando-os a atuar de forma pró-ativa, antecipando-se às mudanças que ocorrem no mercado em que atuam. Diante deste contexto, este trabalho tem como objetivo apresentar o planejamento estratégico realizado na Biblioteca Comunitária da Universidade Federal de São Carlos (BCo/UFSCar) durante o segundo semestre de 2010. Como resultados foram apresentadas as diretrizes estratégicas para a organização. Este planejamento se apresenta como uma opção metodológica, prática e de baixo custo para o aproveitamento de oportunidades e neutralização de ameaças que se apresentam na forma de contingências.
The Effect of Entrepreneurship Education and Curriculum on Student Entrepreneurial Intention moderated by Student Entrepreneurial Mindset
Authors: Purwanti Siska , Handayani Puji , Kusdiyanti Henny
Published: March 2024

Aims: This study aims to analyze the impact of entrepreneurship education and entrepreneurship curriculum on entrepreneurial intention among students, moderated by entrepreneurial mindset in Vocational High Schools.
Study Design:  This research employs a quantitative research design.
Place and Duration of Study: The study was conducted among students of the Center of Excellence Vocational High School in Banyuwangi, with a population of 7249 students (N). The sample size was determined using a Sample Size Calculator, resulting in a sample of 365 participants.
Methodology: The research instrument utilized in this study was a questionnaire employing a Likert scale. Data analysis was conducted using the Partial Least Squares (PLS) technique implemented through SmartPLS version 3.
Results: Entrepreneurship education provides practical knowledge and shapes students' entrepreneurial mindsets, whereas the Entrepreneurship Curriculum offers theoretical foundations and stimulates entrepreneurial enthusiasm. Although the Entrepreneurial Mindset does not moderate the impact of Entrepreneurship Education, it moderates the effect of the Entrepreneurship Curriculum, highlighting the need to align the Curriculum with the development of an entrepreneurial mindset. These findings serve as a basis for improving entrepreneurial education strategies at the vocational high school level.
Conclusion: This study concludes that Entrepreneurship Education, Entrepreneurship Curriculum, and Entrepreneurial Mindset positively contribute to Entrepreneurial Intention among outstanding Vocational High School students in Banyuwangi. These findings illustrate the moderating role of the Entrepreneurial Mindset in mitigating the negative impact of the Curriculum on students' entrepreneurial intention.
A Proposed Costing System for Agile Just-In-Time Supply Chains with Back-Flush and throughput Accounting
Authors: El-Gibaly Mohamed M.
Published: March 2024

According to the new advances in the form of new firms, including JIT and Agile, further advances in technologies, computer programs, and the systems of official accounting all become necessary to be modified. Also, the considerations of kaizen costing systems, in addition to the new movements towards the concern of the customer, should come first as a result of the new movements towards the customer profit analysis. In a JIT supply chain, suppliers are responsible for informing their cus-tomers of their products. Within the context of the current research, it was suggested to use the sys-tems of Back-flush costing as well as throughput accounting systems to simplify the application of just-in time systems and agile systems to satisfy the requirements of achieving the policy of continu-ous improvement. Furthermore, the continuous debate between the different parties of the game supposed here will be realized and considered. The integration of competitors into various aspects of the supply chain has been made possible by the emergence of intelligent supply chains. Additionally, the rapid advancements in the industrial and technological landscape have placed a significant bur-den on the movement of goods and information, requiring efficient and cost-effective solutions to meet time-sensitive requirements and customer demands. It is even more promising to consider the potential for surpassing competitors in terms of achievements and capabilities. The continuous advancements in artificial intelligence have further emphasized the need for progress in both production quality and cost optimization. The rapid progress in both the just-in-time/agile and resilient systems has led to additional requirements for the implemented accounting system and the selected level of automated accounting system. Extensive analysis of various arguments within the scope of the present study has been conducted, promoting the adoption of a more reality-sensitive model for the application.
Specific Diversity of Fish Ponds in the Haut-sassandra and Risks of Contamination by Potential Pathogens among Oreochromis niloticus (Tilapia)
Authors: Frejus Ehui Edi Jean , Clément Kouassi Kouassi , Athanase Kouassi Kra , Serge Ehouman Ano Guy
Published: March 2024

Fishery and aquaculture products are an important source of protein in the human diet and a real source of income for producers. However, fish farming is still less well known among the Ivorian population, and does not yet benefit from technical assistance. This could have an impact on the quality of aquaculture resources. This study was therefore carried out firstly to assess the current state of fish farming in the Haut-Sassandra region, and then to evaluate contamination by potential bacterial pathogens of tilapia fish from fish ponds in this region. To this end, a survey was carried out from June to December 2022 using questionnaires. The survey consisted of direct interviews and farm visits to collect data. Tilapia fish were then sampled and analyzed. It emerged that fish farming is a fast-growing activity in the Haut-Sassandra region, but is practiced in a related way. It is mostly practiced by people aged between 35 and 50, most of whom have a primary education. Females account for 2.66%. The dominant system is extensive, practiced in dam and diversion ponds where several activities coexist. In this region, 100% Tilapia (Oreochromis niloticus), 21% Cameroon (Heterotis niloticus) and 48% Catfish (Clarias gariepinus) are found on all farms. Of the two pond types, the barrage ponds had the best characteristics. Microbiological analyses revealed the presence of potentially pathogenic species, notably Escherichia coli, Staphylococcus aureus Salmonella spp and Enterococcus in tilapia from these fish ponds. Fish farming is a fast-growing activity, but it needs special attention to meet the needs of the Ivorian population.
Compendium: Management of Viral Hemorrhagic Fever (Viral Fever), Involving Its Pathogenesis
Authors: Srivastav Yash , Kumar Aniket , Singh Jaya , Srivastav Aditya , Ahmad Mohd. Imtiyaz
Published: March 2024

The term "Viral Hemorrhagic Fever" (VHF) describes a severe feverish sickness characterized by aberrant vascular control, vascular damage, and hemorrhagic symptoms. Multiple viruses belonging to distinct families are the cause of this illness. The viruses that cause VHF are categorized into seven distinct families according to the International Committee on Taxonomy of Viruses' most recent classification: Hantaviridae, Nairoviridae, Filoviridae, Phenuiviridae, Paramyxoviridae, Arenavidae, and Flaviviridae are the families involved. The concept of virus hemorrhagic fevers (VHFs) originated in the 1930s when Soviet researchers were studying hantaviral hemorrhagic fever (HF) with renal dysfunction. Dengue fever/Dengue haemorrhagic fever and Kyasanur forest sickness are the two most common viral hemorrhagic fevers (VHF) in India that are transmitted by arthropod vectors. The diagnosis of community-acquired pneumonia (CCHF) in India is greatly hampered by the co-occurring symptoms of hemorrhagic fevers such as dengue, Kyasanur forest sickness, Hantavirus hemorrhagic fever, and other illnesses such as leptospirosis, meningococcal infections, and malaria. The pathophysiology, aetiology, diagnosis, treatment, symptoms, and indicators of virus hemorrhagic fevers (VHFs) are all covered in this review article.
Soil Fertility Status of Major Coconut Growing Soils of Tumkur District, Karnataka, India
Authors: Kabber Avinash , Kumar K. S. Anil , Kuntoji Altaf
Published: March 2024

A study was conducted to assess the soil fertility status of major coconut growing soils of Tumkur district of Karnataka with soil pedon locations being Turuvekere and Gubbi. The results revealed that soils of the study area were slightly to strongly alkaline in reaction and non-saline in nature. The organic carbon content was varying from low to high and it followed decreasing trend with soil depth in both soil profiles (Turuvekere and Gubbi). The clay distribution, cation exchange capacity and base saturation of the soils varied from 17.83 to 60.37 per cent, 8.71 to 28.86 cmol (p+) kg-1 and 75.53 to 93.42 per cent, respectively. The macronutrient status of the soil samples indicated that the available nitrogen and phosphorus varied from low to medium, and available potassium content was varying from low to high. Analysis of secondary nutrients showed that exchangeable calcium and magnesium were found to be sufficient but available sulphur was varying from deficient to sufficient level in these soils. The DTPA extractable micronutrients viz., iron, manganese, zinc and boron were found to be deficient in entire study area where as copper was varying from deficient to adequate level with surface soil having relatively high copper content than subsurface soil.
The Role of Adipose-derived Stem Cell in Breast Reconstruction with Fat Grafting: A Literature Review
Authors: Sentoso Joko Wibowo , Putra Agung , Alif Iffan
Published: March 2024

Adipose-derived stem cells (ADSC) are a biological development that provides new hope regarding tissue engineering and regenerative therapy. Due to its potential paracrine activity, compounding, paracrine activity and immunomodulatory function, ADSC-based cell-assisted lipotransfer has emerged as a promising cell therapy technology and significantly improves fat graft retention. Initially used for breast augmentation as a cosmetic function, currently ADSC-based cell-assisted lipotransfer has potential utility for breast reconstruction in breast cancer patients. Post-fat grafting complications of 10.9% were reported and considered major, including hematoma, seroma, fat necrosis, dermatitis, cellulitis, and infection. In this review, we summarize the latest research and aim to provide an overview of ADSC in fat grafting, so that in the future research can be found to avoid post-fat grafting complications in breast reconstruction and provide satisfactory breast reconstruction results.
Feasibility of Probiotics Supplementation in Caged Broilers
Authors: Gautam Amratan , Neeraj  , Pandey Ramesh , Sushma  , Singh Ram Pal , Singh Anand Kumar
Published: March 2024

As part of the Sam Higginbottom University of Agriculture, Technology and Sciences in Prayagraj, this experiment was carried out at the Small Animal Lab which is part of the research unit. We investigated the “economic cost of including probiotics in the feed of caged broilers”. We used a total of 96 day-old chicks and were randomly assigned four groups of 24 chicks (T0, T1, T2, and T3) and eight replicates each, these groups. T0 control group was fed the (BD), T1 was fed Bacillus coagulans at 40 ppm in BD, T2 was fed B.  subtilis at 50 ppm in BD, and T3 was fed B. licheniformis and B. coagulans 20 ppm in BD. After a 35-days trial period, an analysis of the economic effects of the probiotics supplementation was calculated. The results revealed a decrease in FCR as birds achieved more weight, leading to increased body weight and resulting in a higher price per kg. Adding probiotics to the feed doesn’t increase the variable cost than the control group. It was found that the maximum profit was obtained in T3 (Rs. 5771.32), T0 (Rs. 5297.3), and T2 (Rs. 5074.92), whereas the T1 group had the least revenue. Mixing probiotics in poultry feed increases profit without much affecting the production cost.
Challenges in Digital Transformation of Microenterprises in Nueva Ecija: A Basis for Risk Management Plan
Authors: Agustin Noel , Hidalgo Debbyriza T. , Morante Bernardo Jeffrey
Published: March 2024

Digital transformation (DT) has attracted the attention of management and organizational scholars in the past decade. It has become an important factor for the competitiveness of businesses especially with the microenterprises. The use of technology has been the goal of many microenterprises to push forward in the competition and provide better quality products and services to its customers and improve the customer experience through IT innovation. This paper presents the challenges encountered by the microenterprises in Nueva Ecija both on the business and its employees in relation to digital transformation. A structured questionnaire was given to the 359 respondents representing microenterprises in Nueva Ecija, which showed that majority of the respondents were females at an average age of 43 years old. The objective of the study is to determine the challenges in digital transformation of microenterprises in Nueva Ecija. The sample size of 359 respondents answered questionnaires based on the factors like the level of digital skills, degree of digital transformation acceptance, level of technological adoption, implementation of digital transformation, and the challenges encountered in the process of digital transformation. The level of digital skills especially in the management level and employees appears to be high. On the degree of digital transformation acceptance, the microenterprises showed positive or good acceptance on the digital transformation. In the level of technological adoption, the result showed that majority of the microenterprises are moderately applying digital transformation or willing to apply technology in their business. While in the factor of implementing digital transformation in the business, a very small number of microenterprises implement digital technologies in their operation. Most of the microenterprises experienced difficulties in the digital transformation due factors like financial constraints, resistance to change, skills gap and others. The study recommends that microenterprises in Nueva Ecija should conduct regular training to its management and staff for skills development and acquire the necessary technologies as part of its risk management plan. It is also recommended that owners secure funds to digitally transform its businesses to stay competitive. This paper may be of help to the microenterprises owners and future researchers on the topic of digital transformation of microenterprises.
Biochar Activation: A Sustainable Carbon Production from Biomass
Authors: Faldu Dhruv Kumar J. , Lakhani A. L. , Gojiya M. J. , Chauhan P. M.
Published: March 2024

Biochar, derived from biomass pyrolysis, enhances soil fertility, water retention, and mitigates climate change. The global biochar market is projected to reach USD 3.82 billion by 2027. Activation processes, including chemical methods like sulfuric acid modification, enhance biochar's versatility. Modified biochar effectively retains sulfa methazine, improves soil pH, and demonstrates potential in soil enhancement, wastewater treatment, and heavy metal removal. The study explored 18 pyrolysis combinations, revealing physically and chemically activated cotton stalk bio-char characteristics, such as ash content, volatile matter, fixed carbon, and yields of bio-char, bio-oil, and pyro-gas. At 500°C, biochar fixed carbon was nearly three times higher than raw biomass, enhancing its efficacy.
Optical Design
Authors: Mouroulis Pantazis
Published: July 2007

The principles and practices of optical design are reviewed. The necessary background knowledge in geometrical optics, aberrations, and image formation theory is outlined. The process of optical design is described, with emphasis placed on real‐life challenges faced by the designer.
Robust speed estimation and control of an induction motor drive based on artificial neural networks
Authors: Barambones Oscar , Garrido Aitor J. , Garrido Izaskun
Published: July 2007

In this paper, a speed estimation and control scheme of an induction motor drive based on an indirect field‐oriented control is presented. On one hand, a rotor speed estimator based on an artificial neural network is proposed, and on the other hand, a control strategy based on the sliding‐mode controller type is proposed. The stability analysis of the presented control scheme under parameter uncertainties and load disturbances is provided using the Lyapunov stability theory. Finally, simulated results show that the presented controller with the proposed observer provides high‐performance dynamic characteristics and that this scheme is robust with respect to plant parameter variations and external load disturbances. Copyright © 2007 John Wiley & Sons, Ltd.
Transient monoclonal expansion of CD8+/CD57+ T‐cell large granular lymphocytes after primary cytomegalovirus infection
Authors: Rossi Davide , Franceschetti Silvia , Capello Daniela , De Paoli Lorenzo , Lunghi Monia , Conconi Annarita , Gaidano Gianluca
Published: July 2007

Lymphocytosis associated with viral infection is generally polyclonal or oligoclonal. In this article, we describe a case of transient monoclonal CD8+/CD57+ T‐cell lymphocytosis with large granular lymphocyte (LGL) morphology occurring after primary CMV infection and review cases of virus‐associated monoclonal CD8+ T‐cell expansions reported in the literature. Several clinical features shared by virus‐associated monoclonal CD8+ T‐cell expansions suggest the reactive nature of the lymphocytosis. Based on this, our case report and those reported in the literature support the notion that T‐cell receptor clonality per se is not necessarily indicative of malignancy. These observations further corroborate the need for a close follow‐up before assigning the diagnosis of LGL leukemia to individuals developing monoclonal CD8+ T‐cell expansions. Am. J. Hematol., 2007. © 2007 Wiley‐Liss, Inc.
Estimated annual numbers of US acute‐care hospital patients at risk for venous thromboembolism
Authors: Anderson Frederick A. , Zayaruzny Maxim , Heit John A. , Fidan Dogan , Cohen Alexander T.
Published: July 2007

Venous thromboembolism (VTE) is a major US health problem. However, the total number of US inpatients who are at risk for VTE is unknown. Our objective was to estimate the number of US acute‐care hospital inpatients who were at risk for VTE according to criteria established by the Seventh American College of Chest Physicians (ACCP) Consensus Conference on Antithrombotic and Thrombolytic Therapy guidelines for VTE prevention. Using the 2003 Nationwide Inpatient Sample from the Healthcare Cost and Utilization Project (HCUP), patient diagnoses and procedures were examined to identify major surgery patients (age ≥ 18 years, length of hospital stay ≥ 2 days) and medical patients (age ≥ 40 years, length of hospital stay ≥ 2 days). ACCP guidelines were used to estimate the number of surgical and medical patients at risk of developing VTE. Of an estimated 38,220,659 discharges in 2003, 7,786,390 (20%) were surgical inpatients; 44% of which were at low risk for VTE, while 15%, 24%, and 17% were at moderate, high, and very high risk for VTE, respectively. Of the remaining 15,161,586 medical patients, 7,742,419 (51%) met ACCP VTE risk criteria. Over 12 million patients, comprising 31% of US hospital discharges in 2003, were at risk of VTE. Given the existence of internationally‐accepted evidence‐based guidelines for prevention of VTE, research is required to establish if this patient population is receiving recommended VTE prophylaxis. Am. J. Hematol., 2007. © 2007 Wiley‐Liss, Inc.