bluuebunny/crossref_metadata_2025 huggingface dataset:
Wieviel offene Wissenschaft ist drin?
Authors: Kindling Maxi
Published: September 2023

Open Access und Open Science in den Koalitionsverträgen und Wahlprogrammen im Bund und in Berlin Was steht im Ampel-Koalitionsvertrag im Bund?  Der Koalitionsvertrag „Mehr Fortschritt wagen. Bündnis für Freiheit, Gerechtigkeit und Nachhaltigkeit“ von SPD, Bündnis 90/ Die Grünen und FDP kann hier abgerufen werden.
Open Access Update Berlin & Brandenburg 2/2022
Authors: Martin Linda
Published: September 2023

von Sophie Kobialka Dieser Newsletter wird gemeinsam vom Open-Access-Büro Berlin und der Vernetzungs- und Kompetenzstelle Open Access Brandenburg erstellt. Wir wünschen viel Freude beim Lesen. Aus der Vernetzungs- und Kompetenzstelle Open Access Brandenburg Unterstützung im Team der VuK.
Talking trash about "junk DNA": lies about "function" (part I)
Authors: Matheson Stephen
Published: September 2023

Look, in short, at practically anything – the coot's feet, the mantis's face, a banana, the human ear – and see that not only did the creator create everything, but that he is apt to create anything.
Performing Open Access – Ein Workshop für und mit den Darstellenden Künsten
Authors: Martin Linda
Published: September 2023

Von Friederike Kramer und Linda Martin Performing Open Access – der Titel wurde Programm, als sich am 13. Dezember Künstler*innen, Wissenschaftler*innen und künstlerisch-wissenschaftliche Mitarbeiter*innen gemeinsam mit Infrastrukturanbietenden über Bedarfe, die Umsetzung von und Angeboten zu Open Access ausgetauscht haben.
Weekly Sampler 1
Authors: Matheson Stephen
Published: September 2023

I've explained before that I'm busy as an experimental scientist (on sabbatical) who does marriage and parenting as well, so I just can't get to all the blog posts I want to write. (Not to mention the ones I want to read.) And some tidbits and links wouldn't warrant an opus in any case.
Expand-Ahead: A Space-Filling Strategy for Browsing Trees
Authors: Page Roderic
Published: September 2023

For the "to do" list, expand-ahead browsing looks like a useful approach to build upon PygmyBrowse (see my live demo). The approach is described in "Expand-Ahead: A Space-Filling Strategy for Browsing Trees" by McGuffin et al. (doi:10.1109/INFOVIS.2004.21, PDF also here).There is a video on Ravin Balakrishnan's site, which is an AVI file that I haven't bee able to coerce my Mac into playing, hence I've posted it on YouTube.
Metacrap
Authors: Page Roderic
Published: September 2023

Time for a rant. I spend a lot of time fussing with records from sources such as GenBank and DiGIR providers, trying to extract strings that might be identifiers, with a view to linking sequences to specimens (and thus to localities), sequences to publications, publications to GUIDs, etc.
BHL and DOis
Authors: Page Roderic
Published: September 2023

In a series of emails Chris Freeland, David Shorthouse, and I have been discussing DOIs in the context of the Biodiversity Heritage Library (BHL). I thought it worthwhile to capture some thoughts here.In an email Chris wrote:I think the perception that there are two "camps" is unfortunate.
More on Campolo, Darwin, and Hitler
Authors: Matheson Stephen
Published: September 2023

At about the same time that I posted on Tony Campolo's flawed piece on Darwin and racism, Christopher Heard posted a vastly better analysis – "Campolo gets Darwin all wrong" – on Higgaion. Required reading. There may be a quiz.
Sind wir mit dem kommerziellen Open Access auf dem richtigen Weg?
Authors: Neufend Maike
Published: September 2023

Podiumsdiskussion 22. November, 14-15.30 Uhr Eine Veranstaltung in der Reihe: Quo vadis offene Wissenschaft? Eine virtuelle Open Access Woche für Berlin-Brandenburg. Open Access bei wissenschaftlichen Publikationen gewinnt immer mehr an Bedeutung.
Peningkatan Kompetensi Digital Guru SMK Melalui In House Training
Authors: Arifuddin Arifuddin
Published: September 2023

The aim of this community service activity is so that teachers at SMK Negeri 2 Parepare City have understanding and competence regarding the implementation of the independent curriculum. One of the materials is Increasing Digital Competence Through In House Training. The method used is coordination and synchronization with partners, namely the teachers of Negeri 2 Parepare, training and mentoring on the Digital Electronic Archives System system. The results obtained are 1) Increased information and insight among vocational school teachers, 2) Vocational school teachers also have skills in using digital-based filing system software, 3) More than 80% of vocational school teachers have excellent digital-based filing system skills. ..
Jigsaw Effects on Student Learning Outcomes: A Review
Authors: Mubayinah Siti
Published: September 2023

Although cooperative learning strategies provide promise for creating schools that are welcoming to students of all backgrounds, they have not been generally adopted. The Jigsaw system is popular because it is thought to promote students' sociability and learning, and because it seems to be straightforward to apply and follow its four-step teaching framework. A comprehensive assessment of research that has investigated the effects of the Jigsaw method on crucial student educational outcomes was planned and carried out to ensure precise identification of the method's effects. After conducting inductive and deductive topic analyses on 10 Jigsaw studies, three key outcomes emerged: learning (including accomplishment and motivation), social relations, and self-esteem (including academic and social self-esteem). Jigsaw's effects on academic performance (n = 2), motivation (n = 1), social connections (n = 1), and self-perception in the classroom (n = 1) were quantified wherever feasible via supplementary reviews. With the exception of social self-esteem, for which only three studies concluded that the Jigsaw method had positive effects, the primary results of our review focused on the inconsistency of Jigsaw effects and the high degree of variability among studies with regard to all retained student educational outcomes (i.e., achievement, motivation, social relations, and academic self-esteem). Additionally, the findings were consistent across trials. Our analysis sheds light on a number of variables that may account for this variation in research, including sample size, student diversity, and curriculum. The moderating effects of these variables need empirical investigation since they may lead to more effective applications of the Jigsaw technique.
ÂŞIK PAŞA’NIN ALLAH, ÂLEM VE İNSAN ANLAYIŞI
Authors: BARDAKÇI Mehmet Necmettin
Published: September 2023

Âşık Paşa, tasavvufi düşüncesini, Türkçe olarak yazdığı Garib-nâme’de tevhit eksenli olarak açıklamıştır. Âşık Paşa, Allah, âlem ve insan hakkındaki fikirleri başta olmak üzere; tasavvufla ilgili birçok konuda bilgi vermiştir. Doğru bir Allah tasavvurunun önemini vurgulayan Âşık Paşa, insan aklının Allah’ın sanatı karşısında acizliğini fark edip hayran kalacağını ifade eder. Âşık Paşa’ya göre Allah’ın sevgisiyle ve belli bir düzen içinde yarattığı âlem, Hakk’a ulaşma çabasıyla dönmektedir. Allah’ın Kur’an’da övdüğü insan ise, âlemin bir kopyasıdır. Âlemde olan şeylerin tümü onda gizlidir. Bu yüzden Âşık Paşa birçok sufi gibi insanı küçük bir âlem olarak kabul eder. Kâinatın özü olması itibariyle manası gönülde yazılı büyük bir kitaba benzeyen insan, tasavvuf eğitimi alarak Hakk’a ulaşır. Ancak bu süreçte iyiliğin sembolü ruh ile kötülüğün timsali nefis arasında büyük bir mücadele yaşanır. Bu savaşta kalbi bunlardan hangisi ele geçirirse, insana o hâkim olur. Her şehir ya da devletin bir yöneticisi olduğu gibi, insanın organlarının da bir yöneticiye ihtiyacı vardır. Âşık Paşa’ya göre beden şehrinin yöneticisi akıldır. Allah akla sorumluluk yüklemekle birlikte rahmetini de vermiş ve mahlûkatın tümünü ona muhtaç kılmıştır. Bu çalışmada, Âşık Paşa’nın Allah, âlem ve insan hakkındaki görüşleri Garib-nâme odaklı ortaya konacaktır. Bu yapılırken, insanın psikolojik yönünü oluşturan nefis, ruh, kalp ve akıl konusundaki düşüncelerine de değinilecektir.
BATUMLU YESÂRÎ’NİN BİR MECMUADA BULUNAN YENİ ŞİİRLERİ
Authors: KILIÇ Mehmet
Published: September 2023

Şiir mecmuaları herhangi bir şairin kendi eserinde ya da farklı yerlerde yayınlanmış şiirini barındırdığı gibi hiçbir kaynakta bulunmayan şiirleri de gün yüzüne çıkarması bakımından kültür ve edebiyat tarihimizde çok müstesna bir yere sahip olduğu yapılan araştırmalarla ortaya konmaktadır. Şair hayatta iken oluşturduğu divanında veya kendinden sonraki dönemlerde istinsah edilen nüshalarda bulunmayan şiirleri mecmualar aracılığıyla ve araştırmacıların gayretleriyle ortaya konularak şairin divanının eksik kısımları tamamlanmaktadır. Mecmualarda bulunan bu şiirler sayesinde şairin sanat hayatındaki merhaleler de takip edilebilmektedir. Yapılan çalışmalarla birlikte birçok mecmuada şiirlerine ulaşılan şairlerden birisi de Batumlu Yesârî’dir. Bu çalışmada, Süleymaniye Kütüphanesi Galata Mevlevihanesi Koleksiyonu 171 numarada kayıtlı mecmuada yer alan Yesârî mahlaslı şiirler ele alınmıştır. 348 varak olan mecmuanın ilk 232 varağı çalışılmış olmasına rağmen son 116 varağı çalışılmamıştır. Mecmuanın genelinde bulunan Yesârî mahlaslı 124 şiirin 99 tanesi yayınlanmıştır. Söz konusu mecmuadaki toplam 25 şiirden 23 tanesinin Yesârî adına yapılan herhangi bir çalışmada yer almadığı, 1 gazel ve 1 koşmanın değişik kaynaklarda yer almasında rağmen mecmuadaki şiirlerle farklarının olduğu tespit edilmiştir. Bu farklar karşılaştırma yapılma suretiyle dipnotta gösterilmiştir. Edebiyatımızda Yesârî mahlaslı birden çok şairin olması nedeniyle şiirlerin hangi Yesârî’ye ait olduğu konusunda kesin hüküm vermemekle birlikte Yesârî üzerine yapılacak olan yeni çalışmalara katkı sunması amacıyla şiirlerin çeviri yazısına bu çalışmada yer verilmiştir.
HZ. ALİ VE MUÂVİYE’NİN HZ. OSMAN’IN KATLİNDE DAHLİ OLANLARA KARŞI TUTUMU
Authors: PALABIYIK M. Hanefi , ÖZDEMİR Talha
Published: September 2023

İslâm tarihi kaynakları üçüncü Halife Hz. Osman’ın öldürülmesi olayının nasıl cereyan ettiği hususunda çok sayıda belge ve iddia barındırması yanında farklı iddialara rağmen aslında olaya katılan isimlerin neredeyse tamamının kimliği de bilinmektedir. Bu çalışmada, halifenin öldürülmesi olayına isimleri karışan şahıslara karşı Hz. Ali ile Muaviye’nin tutumları ele alınmaktadır. Hz. Osman’ın katledilmesinin ardından halife olan Hz. Ali’nin, Hz. Osman’ın öldürülmesi olayına karışan bu kişileri cezalandırmadığı, dolayısıyla öldürülmesini teşvik ve tasvip ettiği iddia edilmiştir. Bunun en açık sebebi de katl olaya karışan bazılarının, daha sonra gelişen olaylarda Hz. Ali’nin saflarında Muâviye’ye karşı mücadele verenler arasında oldukları iddiasıdır. Böylece Hz. Ali’nin Hz. Osman’ın katillerini çeşitli sebeplerden dolayı tespit edemediği veya cezalandırmak istemesine rağmen vuku bulan olaylardan dolayı meseleyi tehir etmek zorunda kaldığına dair öne sürülen iddialar, tartışılır olmaktadır. Buna karşılık Muâviye’nin de iktidara giden yolda kendini siyaseten güçlendirecek bir fırsat olarak gördüğü Hz. Ali’nin, katilleri etrafında bulundurmakla suçlaması, konunun çıkmazıdır. Bu sebeplerle konu, sürekli olarak gündemdeki yerini korumuştur. Çalışmamızda kaynak tarama yöntemiyle tarihsel bağlam dikkate alınmış ve olayların psiko-sosyal cihetleri de göz önünde tutularak yorumlarına gidilmiştir. Konuyla ilgili temel kaynaklar yanında modern çalışmalar da taranmış ve mesele, bütüncül açıdan ele alınmaya çalışılmıştır.
Correlation between psychological co-morbidities and functional capacity in hospitalized coronary artery bypass graft surgery (CABG) patients.
Authors: Hetal M. Mistry  , Seema S.Lekule
Published: September 2023

Background: Coronary Artery Bypass Graft surgery(CABG) is used to treat blockage or narrowing of one or more coronary arteries, hence it restore blood supply to the heart muscle. It can effectively relieve patient previous symptoms such as discomfort from chest pain (angina), fatigue ,breathlessness and  heart attack and increases life expectancy. It is usually a stressful events for patients. After cardiac surgery. If there is alterations in psychological comorbidities are common during recovery. Functional capacity is ability to perform daily tasks or exercise.This well documented value gives information to the doctors, medical staff, physiotherapist and caregivers to give early intervention for emotional disorders after surgery in hospitalized patients
Aim: to find the Correlation Between Psychological Co-Morbidities And Functional Capacity. In Hospitalized Coronary Artery Bypass Graft Surgery Patients.
Study design: cross-sectional, observational & correlation study.
Method: A total of 40 hospitalized CABG patients from tertiary healthcare centre of a metropolitan city. The assessment tool used in this study was Depression, Anxiety and Stress Scale (DASS-21), 6 Minute walk test(6MWT), and Borg scale. The patients taken who fulfilled inclusion criteria and were willing to participate. After obtaining written consent, the DAS Scale was administered to patient and made to performing 6 minute walk test in cardio-vascular & thoracic surgery(CVTS) wards. For each participants required time was 30-40 mins.
Results: Pearson correlation was used to find correlation between Psychological Comorbidities and Functional Capacity. r value for Psychological Comorbidities (DASS Scale score) and percent predicted value of 6MWT (Functional Capacity) is -.399 which shows weak negative correlation and is statistically significant with p value of 0.011. This implicates that if slightly high DASS Scale score for measuring psychological comorbidities was slightly reduced functional capacity.
Conclusion: The result of this study showed weak negative correlation between Psychological comorbidities and Functional capacity. It may be due to post operative fatigue, incisional pain, unable to fall a sleep, loud noises in wards, coughing etc. So this study gives us an understanding to improve quality of life of patients.
建筑消防设施在高层灭火救援中的应用
Authors: 李 建华
Published: September 2023

为了满足城市居民居住的需要，建筑甚至是超建筑逐渐增多。虽然建筑的出现，解决了城市化进程中的一些难题。但是，建筑的增加，也带来了一些不可避免的问题，比如消防安全问题。建筑发生火灾安全事故的概率较高，一旦发生火灾，往往很难在短时间内扑灭。因此，如何更好地预防和解决建筑消防火灾问题，是新时期我国各地城市管理部门的重要课题。文章旨在研究建筑消防工作中存在的问题，并提出相应的解决对策，以供各地区在建筑消防预防及灭火救援方面提供参考。
如何做好建筑安全施工管理防范措施
Authors: 成 福龙
Published: September 2023

建筑产业的发展速度虽然与日俱增，但是快速发展的背后却暴露出了建筑业的多重安全问题，人员流动大，人员工作时间不稳定，工作任务繁重，工作条件差等原因都是导致建筑施工安全事故发生的主要原因。建筑施工安全事故的发生不但会造成施工任务的中断，还会给人民的生命和财产带来巨大的威胁。本文主要分析建筑工程暴露出来的安全管理问题并制定相应的管理对策，以期提高建筑行业对于安全生产的管理水平，预防和减少建筑施工安全事故。
Two-weighted inequalities for maximal commutators in generalized weighted Morrey spaces on spaces of homogeneous type
Authors: Aydoğdu Ayşenur , Aykol Canay , Hasanov Javanshir J.
Published: September 2023

In this paper we give a characterization of two-weighted inequalities for maximal commutators in generalized weighted Morrey spaces on spaces of homogeneous type \(\mathcal{M}_{\omega }^{p,\varphi }(X)\). We prove the boundedness of maximal commutators \([M,b]\) from the spaces \(\mathcal{M}_{\omega _{1}^{\delta }}^{p,\varphi _{1}}(X)\) to the spaces \(\mathcal{M}_{\omega _{2}^{\delta }}^{p,\varphi _{2}}(X)\), where \(1<p<\infty \), \(0<\delta <1\) and \((\omega _{1},\omega _{2})\in \widetilde{A}_{p}(X)\).
The dilemma of home-based learning and teaching (PdPR)
Authors: Zainun Zainoriza
Published: September 2023

This article narrates my experience as a Special Education Teacher in Perak, Malaysia throughout the period of Home-based Teaching and Learning (PdPR). I faced dilemmas involving parents as facilitators and intermediaries in helping to assess their children’s skills and tasks. I realised that good and continuous communication as well as maintaining positive relationships among pupils, parents, and teachers are very important in implementing meaningful PdPR. In addition, the preparation of a PdPR manual for parents is essential, and they need to be consulted about their roles and responsibilities when helping to complete their children’s assignments at home. This experience can serve as a lesson for teachers implementing PdPR and when giving homework assignments to pupils in the future.
Abstrak
Nukilan ini menceritakan pengalaman saya sebagai Guru Pendidikan Khas sepanjang tempoh pengajaran dan pembelajaran di rumah (PdPR) yang lalu. Saya menghadapi dilema semasa melibatkan ibu bapa sebagai fasilitator dan pemudah cara bagi membantu saya untuk membuat penilaian tugasan kemahiran pembuatan roti anak mereka. Saya menyedari bahawa komunikasi yang baik dan berterusan serta menjaga hubungan sesama murid, ibu bapa, dan guru amat penting bagi menjayakan PdPR yang bermakna. Selain itu, penyediaan manual PdPR kepada ibu bapa juga amat mustahak serta mereka perlu dirunding tentang peranan dan tanggungjawab untuk membantu menyempurnakan tugasan anak-anak di rumah. Pengalaman ini boleh dijadikan sebagai pengajaran untuk guru bagi melaksanakan PdPR pada masa hadapan dan semasa memberikan tugasan kerja rumah untuk murid.
Lietuva pasaulyje – pasaulis Lietuvoje
Authors: Kolevinskienė Žydronė
Published: September 2023

Lietuvos ir Amerikos istoriniai, kultūriniai ir literatūriniai ryšiai / Žydronė Kolevinskienė Lietuva – Anglijoje, Anglija – Lietuvoje (iki XIX a.) / Raimonda Ragauskienė Lietuvos ir Baltarusijos istoriniai ir kultūriniai ryšiai / Rasa Leonavičiūtė-Gecevičienė, Vilius Šadauskas Lietuvos ir Estijos istoriniai ir kultūriniai ryšiai XIX–XX a. / Vilius Šadauskas Lietuvos ir Italijos istoriniai ir kultūriniai ryšiai / Rasa Leonavičiūtė-Gecevičienė Lietuvos ir Latvijos istoriniai ir kultūriniai ryšiai XIX–XX a. / Vilius Šadauskas Lietuvos ir Lenkijos istoriniai ir kultūriniai ryšiai / Rasa Leonavičiūtė-Gecevičienė, Vilius Šadauskas Lietuvos ir Prancūzijos istoriniai ir kultūriniai ryšiai iki XIX a. / Aivas Ragauskas, Raimonda Ragauskienė Lietuvos ir Rusijos istoriniai ir kultūriniai ryšiai / Robertas Jurgaitis Sakartvelo ir Lietuvos istoriniai ir kultūriniai ryšiai / Aivas Ragauskas Lietuvos ir Suomijos istoriniai ir kultūriniai ryšiai XIX–XX a. / Raimonda Ragauskienė, Aivas Ragauskas Lietuvos ir Škotijos istoriniai ir kultūriniai ryšiai iki XIX a. / Aivas Ragauskas Lietuva Švedijoje, Švedija Lietuvoje / Raimonda Ragauskienė, Sigutė Radzevičienė Lietuvos ir Ukrainos istoriniai ir kultūriniai ryšiai XIX–XX a. / Vilius Šadauskas Lietuvos Ir Vengrijos istoriniai ir kultūriniai ryšiai / Raimonda Ragauskienė, Aivas Ragauskas
Identification of Novel Syncytiotrophoblast Membrane Extracellular Vesicles Derived Protein Biomarkers in Early-onset Preeclampsia: A Cross-Sectional Study
Authors: Awoyemi Toluwalase , Jiang Shuhan , Bjarkadóttir Bríet , Rahbar Maryam , Logenthiran Prasanna , Collett Gavin , Zhang Wei , Cribbs Adam , Cerdeira Ana Sofia , Vatish Manu
Published: September 2023

Preeclampsia (PE), a multi-systemic hypertensive pregnancy disease that affects 2-8% of pregnancies worldwide, is a leading cause of adverse maternal and fetal outcomes. Current clinical PE tests have a low positive predictive value for PE prediction and diagnosis. The placenta notably releases extracellular vesicles from the syncytiotrophoblast (STB-EV) into the maternal circulation.To identify a difference in placenta and STB-EV proteome between PE and normal pregnancy (NP), which could lead to identifying potential biomarkers and mechanistic insights.Using ex-vivo dual lobe perfusion, we performed mass spectrometry on placental tissue, medium/large and small STB-EVs isolated from PE (n = 6) and NP (n = 6) placentae. Bioinformatically, mass spectrometry was used to identify differentially carried proteins. Western blot was used to validate the identified biomarkers. We finished our investigation with an in-silico prediction of STB-EV mechanistic pathways.We identified a difference in the STB-EVs proteome between PE and NP. Filamin B, collagen 17A1, pappalysin-A2, and scavenger Receptor Class B Type 1) were discovered and verified to have different abundances in PE compared to NP. In silico mechanistic prediction revealed novel mechanistic processes (such as abnormal protein metabolism) that may contribute to the clinical and pathological manifestations of PE.We identified potentially mechanistic pathways and identified differentially carried proteins that may be important in the pathophysiology of PE and are worth investigating because they could be used in future studies of disease mechanisms and as biomarkers.This research was funded by the Medical Research Council (MRC Programme Grant (MR/J0033601) and the Medical & Life Sciences translational fund (BRR00142 HE01.01)
Identification of Novel Syncytiotrophoblast Membrane Extracellular Vesicles Derived Protein Biomarkers in Preeclampsia: A Cross-Sectional Study
Authors: Awoyemi Toluwalase , Jiang Shuhan , Bjarkadóttir Bríet , Rahbar Maryam , Logenthiran Prasanna , Collett Gavin , Zhang Wei , Cribbs Adam , Cerdeira Ana Sofia , Vatish Manu
Published: September 2023

Preeclampsia (PE), a multi-systemic hypertensive pregnancy disease that affects 2-8% of pregnancies worldwide, is a leading cause of adverse maternal and fetal outcomes. Current clinical PE tests have a low positive predictive value for PE prediction and diagnosis. The placenta notably releases extracellular vesicles from the syncytiotrophoblast (STB-EV) into the maternal circulation.To identify a difference in placenta and STB-EV proteome between PE and normal pregnancy (NP), which could lead to identifying potential biomarkers and mechanistic insights.Using ex-vivo dual lobe perfusion, we performed mass spectrometry on placental tissue, medium/large and small STB-EVs isolated from PE (n = 6) and NP (n = 6) placentae. Bioinformatically, mass spectrometry was used to identify differentially carried proteins. Western blot was used to validate the identified biomarkers. We finished our investigation with an in-silico prediction of STB-EV mechanistic pathways.We identified a difference in the STB-EVs proteome between PE and NP. Filamin B, collagen 17A1, pappalysin-A2, and scavenger Receptor Class B Type 1) were discovered and verified to have different abundances in PE compared to NP. In silico mechanistic prediction revealed novel mechanistic processes (such as abnormal protein metabolism) that may contribute to the clinical and pathological manifestations of PE.We identified potentially mechanistic pathways and identified differentially carried proteins that may be important in the pathophysiology of PE and are worth investigating because they could be used in future studies of disease mechanisms and as biomarkers.This research was funded by the Medical Research Council (MRC Programme Grant (MR/J0033601) and the Medical & Life Sciences translational fund (BRR00142 HE01.01)
Deep Batch Active Learning for Drug Discovery
Authors: Bailey Michael , Moayedpour Saeed , Li Ruijiang , Corrochano-Navarro Alejandro , Kötter Alexander , Kogler-Anele Lorenzo , Riahi Saleh , Grebner Christoph , Hessler Gerhard , Matter Hans , Bianciotto Marc , Mas Pablo , Bar-Joseph Ziv , Jager Sven
Published: September 2023

A key challenge in drug discovery is to optimize, in silico, various absorption and affinity properties of small molecules. One strategy that was proposed for such optimization process is active learning. In active learning molecules are selected for testing based on their likelihood of improving model performance. To enable the use of active learning with advanced neural network models we developed two novel active learning batch selection methods. These methods were tested on several public datasets for different optimization goals and with different sizes. We have also curated new affinity datasets that provide chronological information on state-of-the-art experimental strategy. As we show, for all datasets the new active learning methods greatly improved on existing and current batch selection methods leading to significant potential saving in the number of experiments needed to reach the same model performance. Our methods are general and can be used with any package including the popular DeepChem library.
Economic Characteristics of the Fishing Society of Cangkol Village, Cirebon, Indonesia
Authors: Suryana Asep Agus Handaka , Utami Rizka Zahra , Apriliani Izza Mahdiana , Maulina Ine
Published: September 2023

The welfare of the fishing community in Cirebon City indicates that management and development are not equally distributed. The management and development carried out will not run optimally if there is no in-depth understanding of the characteristics of the regional community. This research aims to map economic characteristics, as well as to analyze the driving and inhibiting factors of the fishing community in Cangkol Village. The research was carried out in April–June 2023. The result showed that the average income of skipper fishermen was Rp. 3,288,195.83, while the average wage for crew members was Rp. 1,183,250.00/month. The fishing community in Cangkol Village are fishermen with a traditional fishing unit with a 3 GT boat, hand line fishing gear, and a one-day fishing system. The types of fish caught are Lutjanus rusellii, Diagramma melanacrum, Lutjanus bitaeniatus Cephalopholis boenack, Scombroides tala, and other fish. The caught fish market is a monopoly. Marketing of catches through two channels, namely through middlemen or directly to consumers with a door-to-door promotion system.
Phytonutrients and Anti-Nutrient Composition of Aqueous Extract of Fermented Seeds of Prosopis africana
Authors: Akpata Ebere Immaculata , Ani Onuabuchi Nnenna , Nwodo Okwesili Fred C.
Published: September 2023

Prosopis africana is a perennial leguminous plant in the genus Prosopis. The seeds are used as food condiment. This study was aimed at evaluating the phytochemical, proximate, vitamin and anti-nutrient compositions of aqueous extract of fermented seeds of Prosopis africana. The analyses were done using standard biochemical methods. Assessment of the bioactive constituents was carried out using gas chromatography-mass spectrometry. The result of the phytochemical analysis revealed quantifiable levels of Steroid, phenols, triterpenes, alkaloids, flavonoids, glycosides, terpenoids and saponin. The result of the proximate analysis showed that fermented seeds of Prosopis africana contains moisture (50.51 ± 0.01%), ash (3.78± 0.004%), crude fat (4.45 ± 0.03%), crude fibre (2.49 ± 0.01%), crude protein (25.27 ± 0.07%) and Carbohydrates (13.56 ± 0.003%). The energy value was 195.37 Kcal/100g. Vitamins A (6.38 ± 0.001), vitamin C (36.77 ± 0.004), Vitamin D (0.43 ± 0.003) and vitamin E (0.84 ± 0.001) were present in the extract. The anti-nutrients detected were tannin (12.27 ± 0.06 mgGAE/kg), Phytate (3.68 ± 1.18 mg/kg), oxalate (44.36 ± 14.16 mg/kg), trypsin (4.72 ± 0.46 mg/kg) and cyanide (0.47 ± 0.14 ppm). A total of seventeen (17) bioactive constituents were found using gas chromatography-mass spectrophotometer which include 1,2-Benzisothiazol-3-amine, 2,5-Dihydroxyacetophenone, Cyclopentasiloxane, Propionic acid, Cyclohexasiloxane, 1,2-Bis(trimethylsilyl) benzene, Cycloheptasiloxane, 2-bromobutyloxychalcone, Cyclooctasiloxane, Fumaric acid, 5-Methyl-2-phenylindolizine, 4-(acridin-9—ylamino)-phenyl)-acetamide, 1,2-Bis(trimethylsilyl)benzene), 5-Methyl-2-phenylindolizine, 1,2-Benzisothiazole-3-propanoic acid, 1,4-Bis(trimethylsilyl) benzene and Cyclotrisiloxane. This study showed that aqueous extract of Prosopis africana seed contains various compounds which are found useful for nutritional and medicinal purposes.
Selective Breeding under a Hierarchical Mating Using Osborne Index Web App
Authors: Raj M. P. , Savaliya F. P. , Patel A. B.
Published: September 2023

The poultry industry has targets to meet consumption trends and thus to produce genetically superior birds with high productivity of egg. Better egg production techniques are recommended, to satisfy in-house and export demand. The correlation of egg production with various parameters is considered by various breeders. With the efforts of breeders to satisfy demand, poultry breeding has introduced individual feed conversion testing, Osborne index, pedigreeing, hybridization, selection index, artificial insemination, and mass selection etc. The most reliable and proven Osborne index states that the maximum efficiency of egg production can be obtained by selection on the basis of a combination of family average and individual record. Technological advances have fostered the poultry sector in the last few decades. ICT led transmutation of processes and practices is apparent in almost all aspects of human activities. Knowledge about a particular breeding technique is required for its prefect implementation. These techniques require a kind of data mining and statistical analysis for matting sires and dams. In the era of 5G, Web Apps can provide better options for providing timely, precise analyzed information to poultry owners or breeders. This paper proposes a device responsive web app for Osborne Index for hierarchical mating using selective breeding.
Variation of Biological and Biochemical Parameters in Patients Receiving Antiretroviral Treatment at the Maradi Regional Hospital during 2021-2022
Authors: Laouali Harouna Amadou Mahaman , Ousmane Abdoulaye , Oumarou Amadou , Kadir Ibrahim Mamadou Abdoul , Mahamadou Gado Amadou , Hassane Boureima , Rachidou Abdou Adamou , Sahada Moussa Saley , Aziz Kabirou Amoussa Abdoul , Moussa Harouna , Mahamadou Doutchi
Published: September 2023

Aims: To follow the variation of some biological and biochemical parameters in HIV-infected patients under antiretroviral treatment at the Maradi Regional Hospital.

Study Design: Retrospective and prospective study

Study Location and Duration: Maradi Regional Hospital; from August 2021 to April 2021, a duration of 9 months.

Methodology: We followed the variation of some immunological and biochemical parameters in patients living with HIV, evaluated the CD4+ T cell counts, the viral load, the leukocyte count, and carried out the measurement of haemoglobin, glycaemia, creatinemia, and ALAT levels in the blood at the follow-up visits (month 0 (M0), month 3 (M3), and month 6 (M6)), except for the viral load and CD4+ T-cell counts, which were measured at M0 and M6, and the HBsAg test at M0.

Results: 99 patients were included in this study. The sex ratio was 2.6 in favour of females. At enrolment, 63.6% of patients had a CD4+ T-cell count < 200/mm³, 56.6% had anaemia, 40.4% had hypoglycaemia and there was a significant increase in patients with an undetectable viral load from enrolment to the last visit at M6. At the end of the study, we observed an improvement in CD4+ T-cell counts, haemoglobin, glycaemia and viral load at each subsequent visit. We did not observe any significant evolution of creatinemia and alanine aminotransferase rate.

Conclusion: At the end of the study, we observed an improvement in CD4+ T-cell count, glycaemia, haemoglobin and viral load. We did not observe any particular change in the biochemical parameters of creatinemia and ALAT levels. This shows the non-toxicity of the antiretroviral treatments. Finally, we observed some difficulties in our study which deserve to be improved.
Assessment of CI Engine Performance Utilizing Palm Oil Biodiesel Blend
Authors: Gajera M. N. , Jishna K. P. , Vadher A. L. , Parmar N. B. , Gaadhe Sarman
Published: September 2023

Experiment was explores vegetable oils as potential future fuels for internal combustion engines, particularly compression ignition engines designed for diesel. However, these oils have distinct properties from diesel, requiring modifications for direct use. Integration approaches include adjusting oil properties or adapting engines. Commonly, transesterification aligns oil properties, but using biodiesel often affects engine performance. In this study palm oil biodiesel as a diesel substitute, evaluating engine performance and emissions. In a short-term test, engine performance and emission traits by employing biodiesel blends of 0, 20, and 50 % with diesel at full load. Findings indicated that B20 and B50 exhibited 2.40% and 3.88% lower brake power than pure diesel. Volumetric efficiency percentages were 82.44 for B20, 81.64 for B50, and 82.93 for diesel. Notably, B20 and B50 showed 9.35% and 10.70 % decreased brake thermal efficiency compared to diesel. Interestingly, B20 and B50 displayed 1.09 and 2.44 % higher mechanical efficiency than diesel. Exhaust gas temperature was notably elevated in B20 and B50 blends. Nitric oxide concentrations were 98.74 ppm for diesel, 105.48 ppm for B20, and 111.78 ppm for B50. Carbon dioxide levels decreased by 4.14% for B20 and 7.86% for B50 relative to diesel. Carbon monoxide concentrations were 0.082% for B20 and 0.080% for B50, in contrast to diesel's 0.10%.
Antibacterial Properties and Chemical Parameters Determination of Medicinal Soap Produced with Acalypha wilkesiana Plant Extracts
Authors: Fawehinmi A. B. , Lawal Hassan , Chimezie E. U. , Fasan T. I. , Ola-Adedoyin A. T.
Published: September 2023

In rural communities of the poor developing economies, dermatophytic infections have become pandermic with about 20-25% of the population affected. The present study was carried out to produce medicinal soaps with antibacterial and antifungal activities using leaf extracts of Acalypha wilkesiana. We compared the antimicrobial properties of different concentrations of the extract of the plant in soap production and the chemical parameters of the produced soap were determined. The soap containing 15% Acalypha wilkesiana showed more activities against clinical strains of Candida albicans and Staphyloccocus aureus at all concentrations with zones of inhibition between 6 – 18 mm compared to values obtained against Proteus mirabilis and pseudomonas aeruginosa. However, soap containing 10% of the medicinal plant was not active against all the test microorganisms at lower concentrations of 10 and 100 µg/mL but the activity increased with increased concentration of the active ingredient in the soap to 1000 and 10,000 µg/mL. However, the soap containing 5% medicinal plant was not active at any of the concentrations. The chemical parameters determined indicated that Total fatty matter (TFM) 47% is within the acceptable limit. The values obtained for Matter insoluble in water (18%), matter insoluble in alcohol (0.5%), Total free acidity (0.7%), Moisture content (7%), pH(10.5) and % Free alkali as Na2O (6.19%) were all within acceptable limit. The Foam stability was determined to be 3.98 mins. It is therefore obvious that the soap containing 15% Acalypha wilkesiana is more effective against the test microorganisms compared to 10% and could be utilized for the management of skin infections.
Evaluation of Injectable Platelet-rich Fibrin (i-PRF) as an Autologous Tissue Regenerator in Facial Aesthetics
Authors: Brodt Fernanda Pirossi , Garcia Roberto Puertas , Costa Michelle Fechine , Marchi Carolyne Martins De , Barja Paulo Roxo , Doria Anelise Cristina Osorio Cesar , Furtado Gisele Rosada Donola , Barbosa Kledson Lopes , Paterno Josne Carla
Published: September 2023

Introduction: Cutaneous ageing, an inherent process with advancing time, often detrimentally impacts self-esteem due to manifestations like wrinkles, blemishes, dehydration, sagging, and reduced tissue vitality. A contemporary trend seeks natural approaches to facial rejuvenation. Injectable Platelet-Rich Fibrin (i-PRF) emerges as a noteworthy solution owing to its biological origin and autologous nature.

Materials and Methods: Evaluating i-PRF's efficacy in counteracting ageing signs, we employed a 16 MHz high-frequency ultrasound device and meticulous photographic documentation. 26 females, aged 35-55, underwent three i-PRF sessions. Statistical scrutiny utilised a paired t-test (α = 0.05) to assess dermal modifications. Self-Perception Index scores underwent Wilcoxon testing (α = 0.05) for significant enhancements. Comparisons of newly captured frontal and profile photographs (D and E) with initial images aided visible change assessment.

Results and Discussion: Compelling data analysis evidenced a notable dermal thickness increase post-intradermal i-PRF application. P-values for examined regions were: glabella (P < .00269), frontal D (P < .00018), frontal E (P < .00014), cheek D (P < .00709), and cheek E (P < .0008). These results underscore substantial dermal thickness alterations. Statistical examination of the Self-Perception Index yielded a P-value < .0001, signifying significant self-perception change post-treatment. Conclusion: Intradermal i-PRF application markedly increased dermal thickness, endorsing its potential for dermal restructuring. Furthermore, this approach presents an accessible, cost-effective, and unbiased alternative for facial rejuvenation.
Cutaneous Vascular Malformations in a 53-Year-Old Woman With Neurologic Symptoms
Authors: Rauterberg Jonas , Schreml Julia , Tantcheva-Poór Iliana
Published: September 2023

A woman in her 50s presented with bluish, keratotic papules and nodules on the lower legs and lipolymphedema of the lower legs. What is your diagnosis?
Aquatic macroinvertebrate abundance in French experimental polyculture fishponds
Authors: Maillot Marie , Roucaute Marc , Jaeger Christophe , Aubin Joël
Published: September 2023

Ponds host a variety of invertebrate species and contribute greatly to global biodiversity. Aquaculture influences macroinvertebrate diversity and productivity in ponds through several practices, such as macrophyte and water management. Fish stocking is also considered controversial for preserving biodiversity through the direct predation upon natural species and changes induced on the biotope.

An experiment examined whether compartmentalized ponds with temporarily fish‐free areas had higher fish productivity and macroinvertebrate abundance and diversity than open ponds.

The experimental design consisted of two treatments—compartmentalized (C) or open (O)—each applied to three ponds. Roach (Rutilus rutilus), tench (Tinca tinca) and common carp (Cyprinus carpio) were stocked in the ponds in March 2021. Juvenile pikeperch (Sander lucioperca) were stocked in the ponds in June. In the C ponds, three areas were created and opened successively: (C1) corresponding to ¼ of the pond surface to host roach, tench and common carp from March to May; (C2) ¼ of the pond surface restricted to fish from March to May; and (C3) ½ of the surface restricted to fish from March to July, except for juveniles of pikeperch which were stocked in June. We investigated patterns in abundance, dry biomass and productivity of macroinvertebrates four times from March to October.

This article presents observed macroinvertebrate abundances and weighted dry biomass, and productivity estimated from them. Overall, 77,749 individuals were identified, of which one‐third were Chironomini and another one‐third were Oligochaeta. The invasive red swamp crayfish (Procambarus clarkii) was found in one pond in October. The two highest taxonomic richness values were found in C ponds (71 and 69 taxa). The lowest taxonomic richness (61 taxa) was in an O pond. Although dry biomass was clearly higher in the C ponds in March, no tendency could be seen between C and O ponds throughout the experiment. No difference in productivity was found between the C and O ponds among the experiment.

By reporting macroinvertebrate abundance, biomass, productivity, size classes, developmental stages and high‐resolution taxonomic identification in a freshwater polyculture system, this dataset is one of the first of its kind.
An Adjustable Adjuvant STINGsome for Tailoring the Potent and Broad Immunity Against SARS‐CoV‐2 and Monkeypox Virus via STING and Necroptosis
Authors: Wu Jun‐Jun , Chen Guan‐Jie , Fan Chen‐Yuan , Shen Fan , Yang Yi , Pang Wei , Zhao Zhen‐Nan , Guan Hong‐Xin , Wu Huan , Lu Ying , Fu Ya‐Juan , Chen Qi , Zheng Yong‐Tang , Ouyang Songying
Published: September 2023

The pandemics induced by emerging SARS‐CoV‐2 variants and monkeypox virus infection have triggered the urgent need for broad‐spectrum vaccines. Except for “super” antigen designs, pattern recognition receptor (PRR) agonist‐based adjuvants might blaze a new trail, through enhancing the immune response of conserved antigen epitopes shared among variants for cross‐protection. Ideal adjuvants with proper adjustments could be conveniently applied to different antigens and antigen types in response to new pandemics. However, general strategies for modulating PRR agonist‐based adjuvant properties to tailor the optimal immunity remain to be further explored. Here,  an adjuvant platform STINGsome is described, composed of a STING agonist and pH‐switchable IP9 liposomes, to simulate viral infection via STING activation and necroptosis. STINGsomes function as an efficient adjuvant to elicit broad and potent immune responses against multiple SARS‐CoV‐2 VOCs (Omicron BA.1, BA.2, BA.3, BA.4/5) and a monkeypox virus. More importantly, the adjuvant properties of STINGsomes can be tuned by simply adjusting the IP9 percentage, owing to distinct kinetics from local release to lymph node stimulation. Thus,  this study provides a relatively simple strategy to adapt an adjuvant platform to different pathogenic antigens, ultimately achieving optimal protective responses.
Double‐Side Passivation of Perovskite Solar Cells for High Performance and Stability
Authors: Kim Beomsoo , Gil Bumjin , Ryu Seokjoo , Kim Jinhyun , Park Byungwoo
Published: September 2023

Perovskite solar cells (PSCs) are in the spotlight as promising renewable energy devices by their appealing properties. However, they face challenges both in power conversion efficiency (PCE) and long‐term stability. The presence of surface defects in the PSCs is a significant obstacle to achieving both high efficiency and stability, as these defects cause nonradiative recombination and degradation. Herein, a novel double‐side surface passivation method using phenyltrimethylammonium iodide (PTMAI) salt is applied to remove electronic defects effectively. Furthermore, double‐side passivation with PTMAI contributes to the enhancement of the perovskite crystallinity with the relaxed non‐uniform distribution of local strains. Finally, the efficiency of PSC is significantly improved by double‐side passivation with PTMAI, achieving a PCE of 21.87%. Furthermore, the passivated cell exhibited enhanced long‐term stability, maintaining over 80% of initial PCE after 1860 and 1030 h under 60 °C and 1 sun illumination, respectively.
Bilayered Oxide Heterostructure‐Mediated Capacitance‐Based Neuroplasticity Modulation for Neuromorphic Classification
Authors: Lin Pei‐En , Chen Kuan‐Ting , Chaurasiya Rajneesh , Le Hoang‐Hiep , Cheng Chia‐Hao , Lu Darsen D. , Chen Jen‐Sue
Published: September 2023

To overcome the limitations of memristors in neuromorphic computation, memcapacitors are gaining attention owing to their scalability, low power dissipation, and sneak‐path‐free nature. This study focuses on the progressive capacitive switching of a bilayered metal‐oxide WOx/ZrOx heterojunction memcapacitor. To gain a better understanding of the interfacial switching behavior, density functional theory simulations are used to analyze the defects and oxide formation energy of the heterostructure. The memcapacitive characteristics are studied using the capacitance–voltage curves under different voltage‐sweeping conditions and impedance analysis. The memcapacitive characteristics can be attributed to the trapping of carriers in the depletion region of the WOx/ZrOx heterojunction, which is modulated by the relocation of oxygen vacancies under the electric field. The device exhibits a wider dynamic range of capacitance values than other metal‐oxide memcapacitors reported, and demonstrates versatile synaptic functions, such as potentiation/depression behavior, paired‐pulse facilitation, experience‐dependent plasticity, and learning–relearning behavior. Furthermore, an accuracy of 99.01% is achieved in handwritten digit classification using the capacitive state as the weight through a computing‐in‐memory emulator. The results affirm the applicability of the WOx/ZrOx memcapacitor in future capacitive neural networks.
Cyclic Stretching Triggers Cell Orientation and Extracellular Matrix Remodeling in a Periodontal Ligament 3D In Vitro Model
Authors: Chiu Kuo‐Hui , Karpat Mert , Hahn Johannes , Chang Kao‐Yuan , Weber Michael , Wolf Michael , Aveic Sanja , Fischer Horst
Published: September 2023

During orthodontic tooth movement (OTM), the periodontal ligament (PDL) plays a crucial role in regulating the tissue remodeling process. To decipher the cellular and molecular mechanisms underlying this process in vitro, suitable 3D models are needed that more closely approximate the situation in vivo. Here, a customized bioreactor is developed that allows dynamic loading of PDL‐derived fibroblasts (PDLF). A collagen‐based hydrogel mixture is optimized to maintain structural integrity and constant cell growth during stretching. Numerical simulations show a uniform stress distribution in the hydrogel construct under stretching. Compared to static conditions, controlled cyclic stretching results in directional alignment of collagen fibers and enhances proliferation and spreading ability of the embedded PDLF cells. Effective force transmission to the embedded cells is demonstrated by a more than threefold increase in Periostin protein expression. The cyclic stretch conditions also promote extensive remodeling of the extracellular matrix, as confirmed by increased glycosaminoglycan production. These results highlight the importance of dynamic loading over an extended period of time to determine the behavior of PDLF and to identify in vitro mechanobiological cues triggered during OTM‐like stimulus. The introduced dynamic bioreactor is therefore a useful in vitro tool to study these mechanisms.
Cholesteric Liquid Crystals Based Micro‐Fingerprints Generator for Anti‐Counterfeiting Labels
Authors: Bruno Mauro Daniel Luigi , Fuoco Erica , Petriashvili Gia , Papuzzo Giuseppe , Forestiero Agostino , Sinopoli Stefano , Emanuele Umberto , Barberi Riccardo Cristoforo , De Santo Maria Penelope
Published: September 2023

In this study, a method is presented to fabricate optical fingerprint‐like patterns. The method relies on the use of commercially available chiral nematic liquid crystals (CNLCs) confined in microspheres. The peculiar optical texture is obtained by applying a high‐frequency voltage to the micrometric objects able to distort the molecular director orientation. The texture can be stabilized by doping the CNLC with photosensitive materials. Each microsphere shows a different fingerprint‐like pattern that is generated in a completely random manner making this procedure suitable to create physical unclonable functions (PUFs) keys. The optical patterns can be stored to create an artificial fingerprints database or they can be used to fabricate electroluminescent labels to be exploited as complex anti‐counterfeiting devices. An authentication software is developed and used to test the robustness of the proposed anti‐counterfeiting system.