bluuebunny/crossref_metadata_2025 huggingface dataset:
Practical experience of a lung cancer primary cell culture collection creation at the National Medical Research Centre for Oncology
Authors: Mezhevova I. V. , Sitkovskaya A. O. , Filippova S. Yu. , Shamova T. V. , Timofeeva S. V. , Gnennaya N. V. , Novikova I. A. , Haragezov D. A. , Milakin A. G. , Leiman I. A. , Stateshny O. N. , Rostorguev E. E. , Atmachidi D. P. , Lapteva T. O. , Voloshin M. V. , Eremin K. S. , Suhar I. A.
Published: December 2022

Purpose of the study. Testing of new chemotherapeutic agents in translational and biology medicine needs studies on immortalized cell lines. However, such models do not always have the biological properties of a tumor in situ, in contrast to primary cell cultures. Primary cultures of lung cancer cells have biological, morphological and molecular characteristics close or identical to tumor cells in vivo. Obtaining collections of primary lung cancer cell lines is an important task in creating various models for preclinical studies.

Materials and methods. The materials are represented by postoperative tumor samples obtained from 25 patients with newly diagnosed lung cancer without prior treatment. The following methods were used to obtain primary cultures: enzymatic dissociation in Hanks' solution with the addition of 300 units/ml collagenase I (Thermo Fisher Scientific, USA), enzymatic dissociation using the Brain Tumor Dissoсiation Kit (Miltenyi Biotec, Germany) and 150 units/ml. ml of collagenase I, as well as the method of explants. The following methods were used to remove fibroblasts: the use of the FibrOut™ system (CHI Scientific, USA), magnetic separation of fibroblasts using Anti-Fibroblast MicroBeads (Miltenyi Biotec, Germany), and cold trypsinization.

Results. We have obtained 15 primary lung cancer cell cultures that have passed the zero order passage. In this work, the method of enzymatic dissociation turned out to be the most effective. Incubation of lung tumor samples with collagenase for 1 hour preserves the viability and adhesiveness of the cells. The explant method did not show its effectiveness for long-term cultivation, there was no migration of tumor cells to plastic. Magnetic separation, as a method of removing stromal components of fibroblasts, showed the greatest efficiency, while maintaining the viability of tumor cells.

Conclusion. The obtained primary cell cultures of lung cancer can be used for many tasks of experimental oncology: studies of the biological characteristics of lung cancer, development of preclinical models for the studies on new chemotherapeutic drugs.
Dynamics of changes in expression of VEGF neoangiogenic factor in tumor tissue bioptates in patients with squamous cell carcinoma of oral mucosa receiving cetuximab treatment and chemotherapy
Authors: Lyanova A. A. , Vladimirova L. Yu. , Ulyanova E. P. , Abramova N. A. , Storozhakova A. E. , Popova I. L. , Tikhanovskaya N. M. , Teplyakova M. A. , Ryadinskaya L. A. , Udalenkova I. A. , Kalabanova E. A. , Kabanov S. N.
Published: December 2022

Purpose of the study. An analysis of changes in the expression of the VEGF neoangiogenic factor in the tumor tissue of patients with squamous cell carcinoma of the oral mucosa receiving targeted therapy with cetuximab and chemotherapy.

Patients and methods. We performed an immunohistochemical study of tumor samples obtained from 60 patients with squamous cell carcinoma of the oral mucosa T3-4N0-1M0. The main group comprised 30 patients who received therapy with cisplatin and fluoruracil plus cetuximab. The control group included 30 patients receiving standard chemotherapy without targeted therapy. Each group was divided into two subgroups with different treatment efficacy: patients sensitive to treatment (n = 17 in the group with cetuximab and n = 12 in the group without cetuximab) and resistant to treatment (n = 13 in the group with targeted therapy and n = 18 in the group with standard chemotherapy).

Results. Quantification of the VEGF expression demonstrated minimal numbers of vessels stained positively for this marker in the field of view in patients of the main group sensitive to chemotherapy and cetuximab. The value was 5.3 times lower than initial values, and 4.3 times lower than in the subgroup of patients resistant to the treatment (the data were statistically significant, р = 0.0132 and р = 0.0455, respectively). In the control group, patients who were sensitive to the treatment showed 1.4 times lower values than initially (р = 0.921), and patients who were resistant to the treatment had 1.1 times lower values than initial values (р = 0.936). The data were not statistically significant.

Conclusions. The study showed that the number of microvessels in patients resistant to chemotherapy and cetuximab was 4.3 times higher than in patients with effective targeted therapy (р = 0.0455). The differences in the control group were not statistically significant.
Estándar probatorio en materia de discriminación
Authors: Arriazu María Elena
Published: December 2022

Sumario:

I. Exordio. II. Carga probatoria. III. Doctrina judicial delos tribunales inferiores. IV. Postura de nuestro máximo tribunal nacional. V. Reflexión final.
El pluriempleo en la Ley de Riesgos de Trabajo:
Authors: Piazza Edder Hernán
Published: December 2022

Sumario:

I. Introducción. II. La importancia del instituto de pluriempleo en la LRT. III. La importancia del instituto de pluriempleo en la LRT. IV. Tipos de contingencias que pueden ser susceptibles de pluriempleo. V. El pluriempleo y el procedimiento ante las Comisiones. VI. Trámite ante la Comisiones Médicas Jurisdiccionalesy su conexión con la etapa judicial. VII. Consideraciones sobre el pluriempleo y la instancia judicial. VIII. A modo de conclusión.
El decreto 329/20 y la tutela judicial efectiva en la jurisprudencia
Authors: Guevara Carina Noemí , Salas Ana María
Published: December 2022

Sumario:

I. Introducción. II. El derecho de emergencia . III. La respuesta jurisprudencial a la violación de la prohibición de despido establecida por DNU 329/2020. IV. Conclusión
Bio-based semi-interpenetrating networks with nanoscale morphology and interconnected microporous structure
Authors: Madboul Samy
Published: December 2022

Creating new bio-based sustainable polymeric materials with similar or better performance than the petroleum-based counterparts  has recently received considerable attention. It will have a significant positive impact on the environment and the sustainable polymer industry. This review article shows a relatively new method based on simultaneous in-situ polymerization and compatibilization of bio-based plant oil and biodegradable thermoplastic polymer to prepare semi-interpenetrating polymer networks (SINs) with unusual nano-scale morphology and interconnected porous structure will be summarized. The SINs were synthesized via cationic polymerization of tung oil in a homogenous solution of poly(ε-caprolactone) as a biodegradable, semi-crystalline, and biocompatible thermoplastic polymer. The degrees of miscibility, nanostructure morphology, and crystallinity was found to be composition-dependent. This relatively new blending method created  a two-phase nanoscale morphology as small as 100 nm for blends with PCL contents of 20 and 30 wt.%. For higher PCL contents (e.g., 50 wt.% PCL blend), a co-continuous, interconnected microscale two-phase morphology was detected. The microporous structure of the SINs was also changed as a function of composition. For example, the interconnectivity and pore size was considerably decreased with increasing PCL content. Furthermore, a considerable decrease in the crystallization kinetics of PCL was observed as the PCL content is higher than or equal to 30 wt.%. While on the other hand, the crystallization kinetics accelerated significantly for 50 wt.%. This novel, low-cost strategy for preparing bio-based SINs with nanoscale morphology and interconnected three-dimensional cluster structures and desired properties should be widely used for creating new polymer systems.
Determination of the bearing capacity of multi-storey buildings from physically non-linear concrete rods
Authors: Немировский Юрий Владимирович , Тихонов Сергей Владимирович
Published: December 2022

В работе рассматривается многоэтажное здание из железобетона. В качестве конструктивной схемы выбран связевый каркас здания с поперечным расположением рам. Колонны и ригели рассматриваются как многослойные композитные железобетонные конструкции. При расчетах учитывается физическая нелинейность диаграмм деформирования и различие предельных деформаций при растяжении и сжатии составляющих фазовых материалов стержней с учетом их массовых нагрузок. Приводятся соотношения для предельных значений нагрузок, при которых деформация не превышает соответствующие предельные значения при растяжении и сжатии в каждом из фазовых материалов колонн и ригелей. Приведены соотношения для определения усилий, моментов, деформаций и прогибов в рассматриваемых стержневых конструкциях.

The paper considers a multi-storey building made of reinforced concrete. As a constructive scheme, a braced building frame with a transverse arrangement of frames was chosen. Columns and crossbars are considered as multilayer composite reinforced concrete structures. The calculations take into account the physical nonlinearity of strain diagrams and the difference in ultimate strains in tension and compression of the constituent phase materials of the rods, taking into account their mass loads. Ratios are given for the limiting values of loads at which the deformation does not exceed the corresponding limiting values in tension and compression in each of the phase materials of the columns and crossbars. Relationships for determining forces, moments, deformations and deflections in the considered bar structures are given.
Generalized analysis of guaranteed explosion destruction of beam structural elements in water
Authors: Володин Геннадий Тимофеевич , Кочергин Денис Сергеевич
Published: December 2022

Представлено решение задач, определяющих процесс воздействия взрыва заряда конденсированного взрывчатого вещества (ВВ) на балку в воде. Отмечено, что этот процесс можно условно разделить на два этапа. На первом этапе происходит формирование импульсной нагрузки взрыва в воде; на втором этапе - воздействие этой нагрузки на элемент конструкции (или конструкцию в целом для соответствующей задачи). Для первого этапа впервые с применением экспериментальных данных получена аналитическая зависимость для удельного импульса от взрыва в воде сферического заряда с заданными физическими и геометрическими характеристиками. На втором этапе в результате решения соответствующей начально-краевой задачи получена зависимость смещения сечений балки для любого момента времени, позволяющая найти условия гарантированного разрушения балки в соответствии с выбранным критерием разрушения. В постановках и решениях соответствующих задач учтены: эффекты отражения возмущенного падающего потока воды от преграды (балки), глубина погружения конструкции и заряда в воду, физические и геометрические характеристики заряда и балки, а также их взаимное расположение в воде, вид закрепления балки на опорах. Отмечено существенное влияние указанных факторов на величину заряда, взрыв которого приводит рассматриваемую балку к её гарантированному разрушению.

The solution of the problems determining the process of the impact of an explosion of a charge of a condensed explosive substance (BB) on a beam in water is presented. It is noted that this process can be divided into two stages. At the first stage, a pulse load is formed an explosion in water; at the second stage, the impact of this load on the structural element (or the structure as a whole for the corresponding task). For the first stage, for the first time using experimental data, an analytical dependence for the specific impulse from an explosion in water of a spherical charge with specified physical and geometric characteristics was obtained. At the second stage, as a result of solving the corresponding initial boundary value problem, the dependence of the displacement of the beam sections for any moment of time is obtained, which allows us to find the conditions for guaranteed destruction of the beam in accordance with the selected destruction criterion. The statements and solutions of the corresponding tasks take into account: the effects of reflection of the disturbed incident water flow from the barrier (beam), the depth of immersion of the structure and the charge into the water, the physical and geometric characteristics of the charge and the beam, as well as their mutual location in the water, the type of fastening of the beam on supports. A significant influence of these factors on the magnitude of the charge, the explosion of which leads the beam in question to its guaranteed destruction, is noted.
Theoretical modeling of metal deformation processes on a casting and forging module of a new modification
Authors: Одиноков Валерий Иванович , Дмитриев Эдуард Анатольевич , Потянихин Дмитрий Андреевич , Евстигнеев Алексей Иванович , Квашнин Александр Евгеньевич
Published: December 2022

Рассматривается задача об определении полей температуры и параметров напряженно-деформированного состояния в металле при обработке в литейно-ковочном модуле. Принцип работы данного устройства совмещает в себе кристаллизацию расплава металла и последующее деформирование в заданный профиль за счет обеспечения подвижности стенок кристаллизатора. Построена математическая модель деформирования материала с учетом трения и теплоотвода на поверхностях контакта с оснасткой. Материал полагается термовязкопластичным, со свойствами, зависящими от температуры. Описан разностный численный метод решения задачи. В вычислительных экспериментах получены поля температуры, скоростей перемещений, напряжений и деформаций для производства полосы из алюминиевого сплава.

The problem of determining the temperature fields and parameters of the stress-strain state in metal during processing in a casting and forging module is considered. The principle of operation of this device combines the crystallization of the metal melt and subsequent deformation into a given profile by ensuring the mobility of the walls of the mold. A mathematical model of material deformation is constructed taking into account friction and heat dissipation on the contact surfaces with the tooling. The material is supposed to be thermo-visco-plastic, with temperature-dependent properties. A difference numerical method for solving the problem is described. In computational experiments, fields of temperature, displacement velocities, stresses and deformations were obtained for the production of a strip of aluminum alloy AD0.
WORLD HERITAGE DESIGNATION AND PROPERTY: THE IMPACT OF PRESERVATION ON THE PRICE OF HISTORIC ASSETS
Authors: Salinger Eyal , Shefer Daniel , Mualam Nir
Published: December 2022

The restrictions and requirements imposed by historic preservation regulations bring about many changes to the rights of property owners. They might impose additional costs, most notably by prohibiting the demolition of designated buildings and thus decreasing property-development opportunities. The objective of this study is to examine what happens following world heritage designations; specifically, if and how such designations impact the property values of historic buildings. Using the hedonic price method, we measure the value of the option to demolish and rebuild that is denied to owners of designated buildings. We also measure the value of preservation regulations, expressed in the prices of apartments in designated buildings. The study area is the “White City” of Tel Aviv, which UNESCO designated as a world heritage site. The findings suggest that the market price of a designated building is on average 12.5% lower than its theoretical value if the building was not subject to historic preservation regulations. Moreover, a premium of approximately 14% was found in the price of apartment units in designated buildings if the building underwent preservation. These findings could have a direct impact on public policies designed to promote the preservation of historical buildings in world heritage sites.
NATO Force Integration Units: Are NFIUs a Valuable Element of NATO Deterrence and Defense Posture?
Authors: Botík Martin , Mazal Jan
Published: December 2022

Russian aggressions against Georgia (2008) and Ukraine (2014) led NATO into unprecedented changes in the NATO deterrence and defense posture at its eastern flank. The establishment of NATO Force Integration Units with their mission to facilitate high readiness forces deployment was one of the measures taken. The role and tasks of NATO Force Integration Units are very complex. They include a variety of different tasks across all levels: strategic, operational and tactical from peacetime up to activation of Article 4 or 5 of the Washington Treaty. Besides the main mission, these tasks consist of: assurance, deterrence, planning, information sharing, situational awareness, and liaison to Host Nation including contribution to strategic communication. The complexity of the performed tasks and their location in capital cities make NATO Force Integration Units an effective and valuable element of the NATO deterrence and defense posture at the eastern flank.
Three new species of Nigrograna (Dothideomycetes, Pleosporales) associated with Arabica coffee from Yunnan Province, China
Authors: Lu Li , Karunarathna Samantha C. , Dai Dong-qin , Jayawardena Ruvishika S. , Suwannarach Nakarin , Tibpromma Saowaluck
Published: December 2022

Coffee is one of the most important cash crops in Yunnan Province, China. Yunnan is ranked as the biggest producer of high-quality coffee in China. During surveys of microfungi from coffee plantations in Yunnan, six fungal strains that resemble Nigrogranaceae were collected. Multi-gene analyses of a combined SSU-LSU-ITS-rpb2-tef1-α sequence data matrix were used to infer the phylogenetic position of the new species in Nigrograna while morphological characteristics were used to deduce the taxonomic position of the new species. Six fungal strains isolated from decaying branches of Coffea arabica represent three new saprobic species in Nigrograna. The three new species, N. asexualis, N. coffeae, and N. puerensis, are described with full (macro and micro characteristics) descriptions, illustrations, and a phylogenetic tree that shows the phylogenetic position of new taxa.
Late Jurassic (Upper Kimmeridgian) Heterobranchia (Gastropoda) of the coral-facies of Saal near Kelheim and the viciniy of Nattheim (Germany)
Authors: Gründel Joachim , Keupp Helmut , Lang Fritz , Nützel Alexander
Published: December 2022

Forty gastropod species of the subclass Heterobranchia are described from the Upper Jurassic (Upper Kimmeridgian) reefal limestones of South Germany, including ten species in open nomenclature and further ten species of uncertain identity. Six species are new to science: Ceritella convexasp. nov., Nerinea donosasp. nov., Endoplocus acutussp. nov., Endoplocus inflatussp. nov., Pseudonerinea ? pseudomelaniformissp. nov., and Itieroptygmatis cylindratasp. nov. A lectotype is designated for Ptygmatis ? tornata (Quenstedt, 1852). With this final part of the study of the Late Jurassic gastropods from Saal and the Nattheim area, a total of 156 species have been reported. Of these species, 125 have been reported from Saal and 54 from the Nattheim area. Only 23 species occur in both Saal and the Nattheim area. The sample sizes (number of specimens) from Saal and the Nattheim area differ considerably and few species are shared. Diversity metrics suggest the same high diversity at both sites. The gastropod fauna from the Saal quarry has yielded particularly much new information – all new species are based on specimens from Saal. With 125 gastropod species from a single outcrop, the diversity at the Saal quarry is the highest from the Kimmeridgian worldwide. In total, up to 300 species of marine macro-invertebrates have been reported from this quarry, which is a very high point diversity. Gastropods are by far the most diverse group from Saal, which is a modern aspect of this fauna.
Hospital Food Waste: Reducing Waste and Cost to our Health Care System and Environment
Authors: Saber Deborah , Aziza Roya , Dreyer Stacia , Sanford Deborah , Nadeau Hannah
Published: December 2022

Food waste economically and environmentally impacts every industry in the U.S., including healthcare systems. The Environmental Protection Agency’s Food Recovery Hierarchy provided the framework for this study that examined how hospitals in one rural northeastern state processes food waste. Methods included semi-structured interviews with hospital nutrition service experts were conducted at seven facilities across the state. Findings indicate: (1) food is largely disposed of via in-sink disposal processes, making quantification difficult; (2) food donation is a viable humanitarian and waste prevention strategy, but is not widely used because of litigious concerns; and (3) culinary education promotes food repurposing strategies. The discussion highlights the need for nurse leaders to inform policy makers about changes that could positively impact the environment while reducing the waste stream and hospital expenditures.
Pseudo subalgebras and pseudo filters in pseudo BE-algebras
Authors: Ahn Sun Shin , Seo Young Joo , Jun Young Bae
Published: December 2022

As a generalization of BE-algebras, the pseudo BE-algebra was introduced by Borzooei et al., and the notions of pseudo subalgebras and pseudo filters in pseudo BE-algebras were defined, and some related properties were investigated. In order to further study pseudo subalgebras and pseudo filters in pseudo BE-algebras, concepts of pseudo atom, atomic pseudo BE-algebra, and atomic pseudo filter are introduced and related studies are conducted. The conditions under which pseudo-filters can be created using a nonempty set, and the conditions under which non-unit elements can be pseudo-atoms are explored. Characterization of atomic pseudo BE-algebra is discussed, and conditions are provided under which pseudo subalgebra can be pseudo filters. The relationship between a set of pseudo atoms and a pseudo subalgebra is considered, and the conditions under which a pseudo filter can be atomic are found.
Practical discontinuous tracking control for a permanent magnet synchronous motor
Authors: Liu Bin , Yu Dengxiu , Zeng Xing , Dong Dianbiao , He Xinyi , Li Xiaodi
Published: December 2022

In this paper, the practical discontinuous control algorithm is used in the tracking controller design for a permanent magnet synchronous motor (PMSM). Although the theory of discontinuous control has been studied intensely, it is seldom applied to the actual systems, which encourages us to spread the discontinuous control algorithm to motor control. Due to the constraints of physical conditions, the input of the system is limited. Hence, we design the practical discontinuous control algorithm for PMSM with input saturation. To achieve the tracking control of PMSM, we define the error variables of the tracking control, and the sliding mode control method is introduced to complete the design of the discontinuous controller. Based on the Lyapunov stability theory, the error variables are guaranteed to converge to zero asymptotically, and the tracking control of the system is realized. Finally, the validity of the proposed control method is verified by a simulation example and the experimental platform.
Evaluation method of motor unit number index based on optimal muscle strength combination
Authors: Xu Qun , Xue Suqi , Gao Farong , Wu Qiuxuan , Zhang Qizhong
Published: December 2022

Repeatability is an important attribute of motor unit number index (MUNIX) technology. This paper proposes an optimal contraction force combination for MUNIX calculation in an effort to improve the repeatability of this technology. In this study, the surface electromyography (EMG) signals of the biceps brachii muscle of eight healthy subjects were initially recorded with high-density surface electrodes, and the contraction strength was the maximum voluntary contraction force of nine progressive levels. Then, by traversing and comparing the repeatability of MUNIX under various combinations of contraction force, the optimal combination of muscle strength is determined. Finally, calculate MUNIX using the high-density optimal muscle strength weighted average method. The correlation coefficient and the coefficient of variation are utilized to assess repeatability. The results show that when the muscle strength combination is 10, 20, 50 and 70% of the maximum voluntary contraction force, the repeatability of MUNIX is greatest, and the correlation between MUNIX calculated using this combination of muscle strength and conventional methods is high (PCC > 0.99), the repeatability of the MUNIX method improved by 11.5–23.8%. The results indicate that the repeatability of MUNIX differs for various combinations of muscle strength and that MUNIX, which is measured with a smaller number and lower-level contractility, has greater repeatability.
Genre, couple et violence dans Love me tender de Jean-Hugues Mirédin
Authors: Bénac-Giroux Karine
Published: December 2022

Dans sa pièce, Love me tender créée en 2017, Jean-Hugues Mirédin convoque aussi bien la parodie, l’humour et les stéréotypes, que la mise en question des phénotypes et des représentations des identités sexuées. La pièce interroge les constructions symboliques genrées au sein d’images scéniques et d’un travail sur les corps imaginaires qui suggèrent une violence et une tension omniprésentes au cœur des rapports sociaux de sexe. Si la virilité devient burlesque ici, le lien reste fort entre érotisation du corps féminin et violence du désir sexuel, tandis que le couple apparaît finalement comme un pur jeu de signifiants.
Apresentação do dossiê
Authors: R. Rota Alesson , Detoni Piero
Published: December 2022

Este dossiê, que convida para a leitura crítica e sob signo da apropriação em sua chave de potência, tem como objetivo (re)pensar a escrita da história, sob os seus vários suportes e performances, em perspectiva global; subvertendo, de alguma forma, a historicização dessa operação a partir do âmbito geográfico estritamente local e/ou nacional, na medida em que o nosso próprio mundo social se orienta por noções, dentre outras, como de globalização, de conectividade, de interatividade e de transnacionalidade.
COMPÊNDIO DE HISTÓRIA DE ROCHA POMBO
Authors: Detoni Piero
Published: December 2022

Este artigo ambiciona rastrear as principais linhas de força que subsidiaram a escrita do primeiro Compêndio de História da América (1900) publicado no Brasil, de autoria do polígrafo paranaense Rocha Pombo. Acreditamos que a obra do autor esteja imersa em uma espécie de “americanização” da República brasileira. Pretende-se discutir estes temas: o embate na duração entre o “espírito americano” e as “forças autoritárias” movimentadas desde a colonização; as marcas do processo civilizador e o silenciamento das culturas não-ocidentais; por fim, a sua proposta de união pan-americana. A principal tese deste trabalho é que a História de Rocha Pombo suprime a diferença através de uma proposta de conciliação entre passado e presente, não havendo reparação ante os males da conquista/colonização em prol de um pan-americanismo capitaneado pelos EUA.
De uma tradição religiosa ao exotismo: balangandãs, uma história de representação (apresentação) de uma prática cultural (1947-1970)
Authors: Ventura Ferreira Elaine Cristina
Published: December 2022

A proposta deste artigo foi refletir sobre como os balangandãs (objeto que integra as práticas religiosas de matrizes africanas), foi interpretado pelo folclorista Paulo Afonso de Carvalho, mas não somente, e discutir o imaginário social construído sobre esse utensílio quando ele foi integrado aos estudos de folclore (área do saber que se institucionalizou como disciplina no país, em 1947). Para responder a questão, usamos como fonte, entrevistas dos folcloristas em jornais, ainda, as narrativas elaboradas sobre esse objeto litúrgico quando foi incorporado à brasilidade por meio da “escrita” museográfica do Museu de Folclore Édison Carneiro. A análise do discurso e a relação texto e contextos pertinentes foram os recursos metodológicos utilizados neste estudo. Assim, esta investigação considera que os folcloristas, embora tenham entendido esse instrumento devocional como algo conectado a experiência religiosa dos africanos escravizados, eles trataram esse bem como exótico no momento em que se construía um lugar para religião de matriz africana no projeto de uma identidade nacional.
A HOMOSSEXUALIDADE E A HOMOPARENTALIDADE EM CENA: NARRATIVAS DE PROFESSORAS DE EDUCAÇÃO INFANTIL
Authors: Blankenheim Thais , Oliveira Menegotto Lisiane Machado de , Quaresma da Silva Denise Regina
Published: December 2022

Este estudo qualitativo objetiva discutir a homossexualidade e a homoparentalidade a partir de narrativas produzidas por 34 professoras atuantes em 17 diferentes escolas de educação infantil do município de Novo Hamburgo (RS). Metodologicamente, histórias narrativas foram usadas como procedimento para acesso a produções imaginativas e, posteriormente, os resultados foram analisados pelo processo de análise de conteúdo (Bardin, 2011). Esses resultados revelam os dilemas que atravessam a temática, como ideias de preconceito e desaceitação, estigmas remanescentes e a influência da patologização e da normatização relacionadas ao assunto. Embora os dilemas estejam presentes, as participantes abordam os significados de família com uma concepção de amor e diversidade. As narrativas das professoras nos possibilitam questionar a maneira como as temáticas elencadas são tratadas nas escolas. De acordo com essa assertiva, sugerem-se novos estudos que investiguem a forma pela qual essas concepções interferem na prática diária das professoras e professores de nosso país.
DA PSICODINÂMICA À PSICOPATOLOGIA DO TRABALHO NO BRASIL: (IN)DEFINIÇÕES E POSSIBILIDADES
Authors: Sousa Duarte Fernanda , Silva Solange , Martínez Maria Júlia , Mendes Ana Magnólia
Published: December 2022

O presente artigo analisou o estado da arte da psicopatologia do trabalho no Brasil, como objeto de pesquisa e como disciplina, a partir de revisão bibliográfica sistemática integrativa. Foi realizado levantamento em bases de dados virtuais utilizando os descritores ‘psicopatologia do trabalho’ e ‘psicopatologia’ (AND) ‘trabalho’. Foram incluídos artigos disponibilizados integralmente em português publicados em revistas com revisão cega de pares contendo os descritores no título, resumo, palavras-chave e/ou corpo do texto. O conjunto final dos textos analisados se constituiu de 28 artigos publicados entre 1992 e 2019 majoritariamente em periódicos da psicologia com psicodinâmica do trabalho como referencial teórico e/ou metodológico. Foram ainda identificadas três tendências no uso do termo ‘psicopatologia do trabalho’ nos artigos: 1) psicopatologia do trabalho como objeto de estudo; 2) como disciplina; e 3) para debater as compreensões das relações entre trabalho e patologias e suas implicações na prática. Enquanto objeto de estudo, as relações entre trabalho e doença mental são negligenciadas. Como disciplina, identificaram-se imprecisões que flexibilizam ou ignoram os limites entre psicopatologia e psicodinâmica do trabalho. Ambas as tendências da literatura podem estar relacionadas com a desconsideração de fatores históricos na determinação da construção dos campos de estudo.
O CONVÍVIO ENTRE ADOLESCENTES EM MEDIDA SOCIOEDUCATIVA DE INTERNAÇÃO
Authors: Balbinot Caroline , Coscioni Vinicius , Rosa Edinete Maria , Koller Sílvia Helena
Published: December 2022

O objetivo desta pesquisa é caracterizar o convívio entre adolescentes em medida socioeducativa de internação, a partir da perspectiva dos adolescentes. Foram realizadas entrevistas semiestruturadas com dez adolescentes entre 16 e 18 anos em uma unidade socioeducativa de Porto Alegre. Os dados gerados nas entrevistas foram organizados a partir de uma análise temática de perspectiva êmica, isto é, geraram-se categorias nativas de acordo com a percepção dos participantes. Os adolescentes revelaram que facções criminosas eram o ponto de partida para o estabelecimento de relações amistosas ou de rivalidade; também descreveram um conjunto de normas que configuravam um pacto coletivo a favor de uma ordem institucional. Relações de amizades foram descritas, indicando a confiança e a segurança como facilitador do momento de internação. Houve ainda o relato da ocorrência de relações sexuais consentidas como resultado do longo período de internação. Os resultados indicam, sobretudo, um clima interpessoal hostil que promove o sofrimento psicológico e agrava a situação de vulnerabilidade. Ademais, a convivência entre adolescentes ociosos sem o devido acompanhamento pedagógico favorece a perpetuação de valores e interesses relacionados ao envolvimento com a criminalidade.
NECROPOLÍTICA E VIDAS NÃO PASSÍVEIS DE LUTO: A (RE)PRODUÇÃO MIDIÁTICA DO INIMIGO
Authors: Silva Maria da Conceição Gomes da , Lima Stephanie Caroline Ferreira de , Lima Aluísio Ferreira de , Barros João Paulo Pereira
Published: December 2022

Este artigo visa discutir a produção da personagem ‘envolvido’ pela narrativa midiática e seus efeitos na legitimação da necropolítica brasileira. Para tanto, faz uso das contribuições teóricas de Cecília Coimbra, Achille Mbembe e Judith Butler para analisar as repercussões das fake News nas redes sociais direcionadas ao jovem Marcos Vinícius da Silva, morto na favela da Maré, no Rio de Janeiro, quando ia para a escola. A maneira como esse assassinato foi tratado nas redes sociais oferece elementos para a compreensão da produção e ratificação da personagem ‘envolvido’ na justificação de mortes de pessoas que participaram (ou não) de situações ilícitas, colocando-os como sujeitos matáveis na atual política de gestão da morte. As considerações finais do trabalho assinalam a urgência de uma postura crítica por parte da mídia e um engajamento teórico-prático que desnaturalize a necropolítica e as relações de poder cada vez mais recrudescidas pela atual conjuntura política no Brasil.
PSICANÁLISE, PRECARIEDADE E IDENTIDADE NA ATUALIDADE
Authors: Pombo Mariana , Birman Joel
Published: December 2022

Baseado nas teorias de Foucault e de Butler sobre poder, norma e sujeito, este artigo pretende problematizar o recurso dos sujeitos à identidade na atualidade e os seus desdobramentos para a clínica psicanalítica. Defenderemos que, por um lado, a identidade representa uma sujeição às normas e tem um efeito encarcerador e mascarador de desejos, mas, por outro, pode ser importante enquanto proteção contra o desamparo. Diferenciaremos, a partir de Butler, precariedade (condição universal, compartilhada) de precarização (condição produzida pela distribuição social diferencial da condição de precariedade) e apresentaremos a hipótese de que, quanto maior o grau de precarização de um sujeito, mais importantes o apego e o reconhecimento identitários. Abordaremos especificamente o tema das identidades trans, por sua radicalidade no que diz respeito à condição precária e à busca de reconhecimento. Por fim, recorreremos ao conceito de feminilidade do final da obra de Freud enquanto dispositivo de escuta clínica que permita a transformação de cristalizações identitárias no sentido do novo, do singular e das múltiplas identificações.
EMOCIONES Y CUIDADOS EN EL CONFINAMIENTO HOGAREÑO DURANTE LA PANDEMIA DE COVID-19
Authors: De Grande Pablo , Frasco Zuker Laura , Gaitán Ana Cecilia , LLobet Valeria
Published: December 2022

El artículo problematiza, a través de relatos de prácticas cotidianas de cuidado, emociones que se organizan en torno a las diferentes configuraciones del cuidado infantil en el Área Metropolitana de Buenos Aires (Argentina). De esta forma, se trata de alimentar la mirada de las infancias, maternidades y paternidades urbanas en ‘plural’, con la meta de poder considerar el amplio repertorio de formas de disponerse, de estar y sentir que atraviesan el arco de experiencias de los arreglos familiares y el cuidado de hijos e hijas. ¿Cómo se reorganizaron los cuidados domésticos durante la pandemia? ¿Qué emociones y ‘reglas del sentir’ esto puso en evidencia? ¿Cómo impactaron los cambios en las fronteras del ‘adentro’ y el ‘afuera’ en las familias y en las subjetividades laborales y personales? Un primer nivel de análisis de la información empírica está estructurada por las formas de habitar (quiénes vivían con quiénes en términos de parentesco, con qué tipos de vivienda, haciendo qué uso del barrio), para presentar sobre ellas las tensiones emocionales, necesidades y estrategias que emergieron en los relatos.
CONSTITUIÇÃO IDENTITÁRIA DOCENTE EM DRAMATIZAÇÃO: DINÂMICA DOS POSICIONAMENTOS EM CONFLITO
Authors: Araújo Patrício Câmara , Borges Fabrícia Teixeira
Published: December 2022

A presente pesquisa tem como objetivo investigar o processo de constituição identitária docente de licenciandos através da dinâmica dos posicionamentos em conflito, nas narrativas e dramatizações. Esta pesquisa é qualitativa e tem como perspectiva a psicologia cultural em interface com o dialogismo bakhtiniano. Para a construção dos dados, utilizamos como procedimento metodológico entrevistas narrativas individuais e videogravações da elaboração e realização da dramatização pelos próprios estudantes, além da entrevista coletiva mediada pela dramatização. Para a organização dos dados, elaboramos tabelas de temas e subtemas e mapas semióticos individuais, articulados em um mapa coletivo. Em seguida, aplicamos a análise temática dialógica da conversação, com destaque para os temas das narrativas e dos processos dialógicos dos posicionamentos nos encontros conversacionais. Identificamos, na análise dos dados, que aconteceram conflitos na dinâmica dos posicionamentos e nas estéticas docentes, tradicional e progressista, dos participantes; o que implica no processo de constituição identitária docente dos licenciandos ao produzirem significados e sentidos que orientaram as suas atuações docentes.
Palavras-chave: Identidade; posicionamento; conflito
Gender differences in diagnostic tools, medication, time to medication, and nonmotor symptoms in Parkinsonian patients
Authors: Skogar Örjan , Nilsson Mats , Lökk Johan
Published: December 2022

BACKGROUND:

Swedish National Quality Registers (NQRs) play an important role in collecting large amounts of diagnosis-specific data, symptoms, and treatments. The subset of data, Parkinson's Registry, has been in use for more than 20 years and represents all counties and hospitals in Sweden where neurological care is provided.

OBJECTIVE:

To study the differences between genders regarding diagnostic tools, pharmacological interventions, and self-reported symptoms in patients with symptoms originating from basal ganglia disease, either idiopathic or secondary Parkinsonism (PD).

METHODS:

PD-diagnosed patients from a mix of urban and rural locations were chosen from the NQR and sorted by gender. Self-reported, first-experienced PD-related symptoms defined the debut point of PD.

RESULTS:

In all, data from 1,217 patients were analyzed: 502 (41%) females/715 (59%) males. A total of 493 imaging investigations were performed, where of 239 (48% females/52% males) had a CT scan performed, 120 (24% females/29% males) had a dopamine transporter scans, and 134 (23% females/26% males) had a magnetic resonance imaging performed (Fisher's exact test, P = 0.19). The average time in years from symptom onset to start of first treatment, and from first to second added treatment was 2;7/2;9 (females) and 5;1/5;2 (males). Nonmotor symptoms were more prominent among males, especially in memory and gastrointestinal domains, including drooling and obstipation. Significantly more sexual problems were reported from males; 26% versus 7% (Fisher's exact test, P < 0.0001).

CONCLUSIONS:

Differences between genders were identified in this study. Sexual problems and cognitive decline were more frequent among males. More advanced diagnostic imaging techniques were performed among males. The time point for a second added medication was earlier for males than females.
Unaffected ex vivo clotting cascade by experimental hemostatic nanoparticles when introduced in the presence of recombinant tissue plasminogen activator
Authors: Beyer Margaret , France John , Nagaraja Tavarekere N. , Lavik Erin B. , Knight Robert A. , Lewandowski Christopher A. , Miller Joseph B.
Published: December 2022

CONTEXT:

Hemostatic nanoparticles (hNPs) have shown efficacy in decreasing intracerebral hemorrhage (ICH) in animal models and are suggested to be of use to counter tissue plasminogen activator (tPA)-induced acute ICH.

AIMS:

The objective of this study was to test the ability of an hNP preparation to alter the clotting properties of blood exposed to tPA ex vivo.

MATERIALS AND METHODS:

Fresh blood samples were obtained from normal male Sprague-Dawley rats (~300 g; n = 6) and prepared for coagulation assays by thromboelastography (TEG) methods. Samples were untreated, exposed to tPA, or exposed to tPA and then to hNP. TEG parameters included reaction time (R, time in minutes elapsed from test initiation to initial fibrin formation), coagulation time (K, time in minutes from R until initial clot formation), angle (α, a measure in degrees of the rate of clot formation), maximum amplitude (MA, the point when the clot reaches its MA in mm), lysis at 30 min after MA (LY30, %), and clot strength (G, dynes/cm2), an index of clot strength.

STATISTICAL ANALYSIS USED:

Kruskal–Wallis test was employed to compare TEG parameters measured for untreated control samples versus those exposed to tPA and to compare tPA-exposed samples to samples treated with tPA + hNPs. Significances were inferred at P ≤ 0.05.

RESULTS:

Compared to untreated samples, tPA-treated samples showed a trend toward decreased angle and G suggesting potentially clot formation rate and clot strength. The addition of hNP did not affect any of these or other measured indices.

CONCLUSIONS:

The data demonstrated no hemostatic effects when the hNP was used in the presence of tPA. The lack of change in any of the TEG parameters measured in the present study may indicate limitations of the hNPs to reverse the thrombolytic cascade initiated by tPA.
Branch atheromatous disease and treatment
Authors: Duan Honglian , Yun Ho Jun , Geng Xiaokun , Ding Yuchuan
Published: December 2022

Branch atheromatous disease (BAD) is a subtype of ischemic stroke caused by perforating arteries occlusion due to proximal atherosclerosis of the arteries. Early neurological deterioration and recurrent stereotyped transient ischemic attacks are typical clinical manifestations of BAD. The optimal treatment for BAD has not been determined. This article explores a possible mechanism of BAD and effective treatment measures to prevent early progression and attack of transient ischemic events. This article explains the current status of intravenous thrombolysis, tirofiban, and argatroban for BAD and subsequent prognosis.
Hyperuricemia – A narrative review
Authors: Chen Chieh
Published: December 2022

Gout is an inflammatory disease caused by the accumulation of monosodium urate crystals in joints, cartilage, synovial bursa, tendons, and soft tissues. Gout is highly associated with hyperuricemia. Gout is not a new disease, which was first documented nearly 5000 years ago. Tophi are solid nodules that develop in the joints of people with uncontrolled chronic gout. Recently, many studies have advocated that hyperuricemia and gout are associated with insulin resistance syndrome. Hyperuricemia is also an independent risk factor for cardiovascular diseases. Recently, the prevalence of gout has increased globally, imposing a great disease burden worldwide. Moreover, gout or hyperuricemia is associated with various comorbidities, including cardiovascular diseases, metabolic syndrome, chronic kidney disease, urolithiasis, diabetes mellitus, thyroid dysfunction, and psoriasis. Furthermore, research has shown a correlation between high uric acid levels and type 2 diabetes, high blood pressure, and fatty liver disease. High uric acid levels may lead to permanent bone, joint, and tissue damage, kidney disease, and heart disease.
Adenomatoid Odontogenic Tumors
Authors: Nwoga Mark C.
Published: December 2022

Adenomatoid odontogenic tumors (AOTs) are very rare. We present a case series of eight AOTs seen and managed at University of Nigeria Teaching Hospital (UNTH), Ituku-Ozalla, Enugu State, Nigeria over a 10-year period, from 2012 to 2021. Their epidemiological data and clinic-pathological information were obtained from the biopsy forms, histopathology reports, and case files archived in the Records Department of the hospital. The AOTs were diagnosed in 8 patients out of the 225 odontogenic tumors seen during the period giving a prevalence of 3.6%. Five patients (62.5%) were males, whereas three (37.5%) were females giving a male-to-female ratio of 1.7:1. The mean (SD) age at onset of lesion was 12.4 (5.4) years with a range of 5–21 years. The location of the tumors was anterior in 62.5% of the jaw cases. A maxillary location was observed in 62.5% of the cases. Pain complaint was reported in 25% of the subjects. Tumor fluid was aspirated in 75.0% (n = 6) of the lesions: straw aspirate (83.3%),and dark-brown aspirate (16.7%). A tooth was associated with the tumor in 87.5% (n = 7) of the cases, with the canine impacted in 85.7% (n = 6) of these. Only one case (12.5%) was extrafollicular. The AOTs are uncommon and differed from other Nigerian studies by exhibiting a male gender prevalence, lower mean age, and frequent straw aspirates.
Assessment of Relationship between Anthropometric Measurements and Reproductive Hormonal Profiles, Among Females of Childbearing Age at a Tertiary Health Facility in Nigeria
Authors: Oladosu Waliu O. , Alayo Adewale M. , Ahmed Aminat O. , Jimoh Olanrewaju S. , Olarinoye-Raji Sekinat T. , Egbeyemi Basirat A. , Ajadi Taofeek A.
Published: December 2022

Background:

Increasing prevalence of overweight and obesity has profound impacts on health generally, including the reproductive system. Traditionally, pear body shapes, from narrow waist and wide hip circumferences, have been associated with high fecundability among females. Although this has been scientifically demonstrated by a number of researches only a few of these investigations were conducted with black women in Africa who were of reproductive age.

Objectives:

The objectives of the study were to compare the mean reproductive hormone levels between the different waist-to-hip ratio (WHR) and body mass index (BMI) categories and also to determine the correlations between the two anthropometric measurements and the reproductive hormones in a black African population.

Materials and Methods:

It was an analytical cross-sectional study of 180 females of a childbearing age. The WHR and BMI were measured as per standard recommendations. Serum levels of follicle stimulating hormone (FSH), luteinizing hormone (LH), prolactin, estradiol, day-21 progesterone, and testosterone were assayed.

Results:

A majority of the research participants were within the age group 21–30 years. Thirty three percent (33%) and 28.9% of participants were overweight and obese, respectively, using BMI compared with 26.7% and 20%, respectively, using WHR. Seventy six point nine percent (76.9%) of participants with an optimal BMI range ovulated with 61.5% having adequate luteal phase support compared with 75% and 54.2%, respectively, using WHR. Day-21 serum progesterone and serum estradiol were significantly negatively correlated with WHR and BMI (P< 0.05). BMI, however, showed a better correlation than WHR (r = -0.535 vs. -0.397;P= 0.001 vs. 0.008, respectively). Gonadotropins were significantly lower among overweight and obese groups for both BMI and WHR (P< 0.05), but only WHR showed moderately positive significant correlation with gonadotropins (LH: r = 0.050 vs. r = 0.215,P= 0.003, respectively; FSH: r = 0.159 vs. r = 0.431,P= 0.001, respectively), same as serum testosterone (r = 0.580 vs. r = 0.611,P= 0.002, respectively).

Conclusions:

Anthropometric measurements can serve as objective clues to functionality and optimal concentrations of reproductive hormones. Weight control should therefore aid the optimization of reproductive hormones and fertility among females of reproductive age.