bluuebunny/crossref_metadata_2025 huggingface dataset:
What Feminist Bioethics Can Bring to Synthetic Biology
Authors: Rogers Wendy A. , Dalziell Jacqueline
Published: November 2023

Synthetic biology (synbio) involves designing and creating new living systems to serve human ends, using techniques including molecular biology, genomics, and engineering. Existing bioethical analyses of synbio focus largely on balancing benefits against harms, the dual-use dilemma, and metaphysical questions about creating and commercializing synthetic organisms. We argue that these approaches fail to consider key feminist concerns. We ground our normative claims in two case studies, focusing on the public good, who holds and wields power, and synbio research projects’ particularity and context. Attention to feminist concerns is essential for synbio to realize its potential in ethically justifiable ways.
Las Redes Alimentarias Alternativas en el occidente de México ante la contingencia sanitaria por covid–19
Authors: Leal Martínez Gregorio , Rodríguez Guerrero Rodrigo
Published: November 2023

Ante los efectos negativos del actual modelo agroalimentario, y las desigualdades que genera, las Redes Alimentarias Alternativas (realt) se han configurado como un actor clave en la construcción de un modelo más justo y sustentable de producción, distribución y consumo de alimentos. Estas redes fortalecen procesos territoriales, abonan a la conservación del medio ambiente, ayudan a mejorar la salud nutricional y consolidan relaciones sociales horizontales entre quienes producen los alimentos y quienes los consumen. La contingencia sanitaria derivada de la pandemia de covid–19 ha impactado fuertemente a estas redes y ha obligado a generar innovaciones que les permitan seguir funcionando. La comunicación a través de redes sociales o la generación de estrategias para hacer entregas a domicilio son algunas de las prácticas que han ido instrumentando para conservar canales de distribución entre sus usuarios. El presente trabajo hace un abordaje de las REALT en el occidente de México en donde a través de tres ejes conceptuales (Economía Social y Solidaria, Agroecología y Soberanía Alimentaria) y distintas categorías analíticas se establece el funcionamiento y los retos que se han presentado en estas organizaciones a partir de la contingencia sanitaria.
Ruralidad y resistencia en la construcción de territorio(s) de periferia. El caso de las comunidades locales de Tumaco, Colombia, en la postpandemia
Authors: Rodríguez Echeverry Natalie , Burbano González David
Published: November 2023

El capítulo analiza cambios y transformaciones que han sufrido parte de las periferias urbanas y rurales del municipio de Tumaco en Colombia a partir de la pandemia. Desde una perspectiva dirigida hacia el fortalecimiento de las economías locales y sus impactos territoriales, la investigación se centra en los estudios de caso de comunidades vulnerables que por sus propios medios han logrado enfrentar la crisis sanitaria de la pandemia mediante estrategias de organización autónoma, fundamentada en sus conocimientos y tradiciones locales a partir de mecanismos de autoorganización de actividades productivas locales directamente vinculadas al aprovechamiento de los recursos naturales que su entorno les ofrece. En ese sentido, organizaciones de pescadores, cooperativas de productores de cacao y asociaciones de recolectoras de concha demuestran entendimientos y construcciones del territorio como estrategias resilientes a crisis —en este caso sanitarias— propias de un contexto cultural y social que históricamente ha sido afectado por múltiples situaciones de conflictos no solo sanitarios sino también sociales, económicos.
Numerical study optimation design of CPU cooling system analysis using CFD method
Authors: Yudanto Fajar Dwi , Inderanata Rochmad Novian , Johan Arif Bintoro , Setuju Setuju
Published: November 2023

Computers often experience damage to the CPU, especially the mainboard and processor, due to several factors, including human error or excessive use and environmental conditions. Component placement is frequently utilized to improve the CPU room conditions to keep it cool. This research numerically investigates desktop PC processors and heatsink configurations for mechanical engineering vocational learning. The kind of metal material, number of fans, and fan arrangement were all tested at three levels. The computer components in this research are the CPU, heatsink, fan, and processor—a 65-watt Thermal Design Power (TDP) CPU with a constant air intake speed of 5 m/s. The criteria investigated include metal type (steel, aluminum, and copper), cooling design (horizontal, vertical, and mixed), and fan count (2-4-8). The methods used in this research are the Computational Fluid Dynamics (CFD) method and the Taguchi method to examine fluid flow characteristics and temperature. Numerical results show the maximum temperature is 123 °C in the vertical, eight-fan, and steel configurations. Minimum temperature 39.22 °C in mixed configuration, eight fans, and copper. These findings reveal that the kind of metal material, number of fans, and fan arrangement all impact the CPU cooler and heatsink configuration. However, the Taguchi method can provide a more detailed understanding of configuration.
Perlindungan Hukum Terhadap Eksploitasi Anak Jalanan (Studi Kasus di Dinas Sosial Kota Semarang)
Authors: Zaradiva Assyifa Mahend , Megawati Wenny
Published: November 2023

Eksploitasi anak jalanan merupakan salah satu jenis tindak pidana yang sering terjadi akhir-akhir ini, banyak anak jalanan yang kehilangan haknya dan tidak memiliki perlindungan yang layak dari keluarga, komunitas, atau pemerintah. Dalam rangka meningkatkan perlindungan terhadap anak, khususnya anak jalanan, maka melalui peran Dinas Sosial Kota Semarang memberikan perlindungan terhadap eksploitasi. Tujuan penelitian ini adalah mengetahui peran Dinas Sosial Kota Semarang dalam upaya penanganan dan memberikan perlindungan hukum serta hambatan Dinas Sosial Kota Semarang dalam memberikan perlindungan hukum terhadap anak jalanan sebagai korban eksploitasi. Penelitian ini menggunakan metode yuridis sosiologis, merupakan metode penelitian yang berpegang pada hukum dan mengacu pada hal nyata dan penerapan dalam masyarakat. Data penelitian ini diperoleh melalui wawancara Dinas Sosial Kota Semarang. Hasil Penelitian yang didapat bahwa peran Dinas Sosial Kota Semarang dalam memberikan perlindungan hukum kepada korban eksploitasi yaitu melalui tahapan implementasi Perda Nomor 5 Tahun 2014 terdiri pengendalian sewaktu-waktu, penampungan sementara, pendekatan awal, pengungkapan dan pemahaman masalah (assesment),bimbingan sosial dan pemberdayaan, dan rujukan. Hambatan Dinas Sosial Kota Semarang dalam memberikan perlindungan hukum terhadap anak korban kekerasan seksual diantaranya komunikasi, Dinas Sosial Kota Semarang seringkali kesulitan dalam pendekatan terhadap anak yang terjaring razia.
Tinjauan Yuridis Terhadap Problematik Penerapan Pidana Mati Dari Perspektif Hak Asasi Manusia
Authors: Badaru Baharuddin
Published: November 2023

Penelitian ini bertujuan untuk mengkaji dan menjawab permasalahan hukum terhadap Penerapan Pidana Mati Dari Perspektif Hak Asasi Manusia (HAM) dan penanggulangan untuk terpidana mati. Penelitian ini menggunakan metode penelitian hukum normatif. Hasil penelitian ini menunjukkan bahwa : Penerapan pidana mati di Indonesia dampak dari pada penerapan sanksi. Statistik angka dan hipotesis beberapa pakar kriminologi menemukan fakta tidak adanya bukti ilmiah yang menunjukkan bahwa eksekusi hukuman mati memiliki efek jera yang lebih besar daripada hukuman penjara seumur hidup untuk mengurangi angka kejahatan. Pengaturan pidana mati dalam sistem hukum di Indonesia bertentangan dengan hak asasi manusia yaitu hak untuk hidup yang tercantum dijamin oleh Undang-undang Dasar 1945. Rekomendasi penelitian adalah jika hukuman mati masih menjadi salah satu pemidanaan di Indonesia dari instansi penegakan hukum maka harus dilakukan evaluasi setiap rangkaian proses peradilan dan mengedepankan prinsip kehati-hatian dalam penjatuhan hukuman mati Namun hukuman seumur hidup jauh lebih bisa memberi efek jera sebab manusia pada umumnya memiliki ketakutan yang jauh lebih besar saat kebebasannya dibatasi di dalam sel tahanan
PERAN SURAU TV DALAM MENYEBARKAN DAKWAH
Authors: Syahdanta Muhammad Fadilah , Syafriwaldi Syafriwaldi
Published: November 2023

Permasalahan dalam penelitian ini adalah, adanya tanggapan bahwa Surau TV adalah sebuah televisi dakwah yang berada pada sebuah “aliran” atau organiasi Islam tertentu. Penelitian ini menunjukkan tanggapan para pemirsa terhadap tayangan Surau TV, peran Tim Kreatif Surau TV dalam menyebarkan dakwah, dan permulaan Surau TV sebagai televisi dakwah serta faktor pendukung dan penghambat Surau TV dalam menyebarkan dakwah. Metode penelitian yang digunakan ialah kualitatif dengan pendekatan (field research). Hasil penelitian menunjukkan bahwa: pertama, berdasarkan tanggapan para pemirsa, bahwa Surau TV memiliki karakteristik dalam tayangannya dengan menggunakan unsur budaya dan bahasa Minangkabau. Kedua, Tim Kreatif Surau akan terbentuk jika ada sebuah program acara yang dijalankan. Ketiga, Surau TV adalah televisi dakwah berbasis Ahlusunnah Wal Jam’ah yang ada di tanah Minangkabau. Dakwah  Surau TV juga mendapatkan banyak dukungan dari berbagai pihak, mulai dari pemerintah, sosial, dan yang lainnya. Hambatan juga tidak luput bagi Surau TV, mulai dari adanya ketidaksesuaian padangan masyarakat terhadap dakwah yang ditayangkan Surau TV, internet yang bisa mempengaruhi kualitas siaran serta listrik yang mempengaruhi aktifitas tayangan. Dukungan serta hambatan harus dilalui oleh Surau TV, agar mampu Surau TV mampu menjadi televisi dakwah yang lebih baik dan mampu menjawab permasalahan umat.
STRATEGI PROMOSI PASAR VAN DER CAPELLEN
Authors: Putra Rezki , Marhen Marhen
Published: November 2023

Permasalahan dalam penelitian ini adalah bagaimana Strategi promosi pasar Van der Capellen dalam meningkat pengunjung. penelitian ini bertujuan untuk mengetahui dan menjelaskan bagaimana Strategi promosi pasar Van der Capellen dan apa yang menjadi faktor pendukung serta penghambat strategi Pasar Van der Capellen. Jenis penelitian yang penulis gunakan adalah penelitian deskriptif kualitatif. Teknik pengumpulan data yang penulis gunakan adalah melalui observasi, dokumentasi dan wawancara. Pengelolaan data yang dilakukan secara deskriptif kualitatif. Hasil penelitian menunjukkan bahwa  Strategi promosi Pasar Van der Capellen menggunakan periklanan (Advertising) yang memanfaatkan media sosial sebagai media promosi dan kerjasama dengan Dinas-dinas terkait Faktor penghambat promosi Pasar Van der Capellen berasal dari dalam diri masing-masing pengurus pasar Van der Capellen karena belum terjalinnya kerjasama yang baik antara pengurus serta adanya komentar-komentar negatif mengenai postingan yang di upload di media sosial instagram dan faktor pendukung Promosi Pasar Van der Capellen adanya kerjasama dari Dinas terkait serta pihak lain seperti Emersia Hotel, Wartawan, agen Travel and Tour maupun Photografer terhadap promosi Pasar Van der Capellen sehingga Promosi Pasar Van der Capellen tetap terjalankan.
Moral awareness and different orders of relevance in participatory research with older people and professionals (online first)
Authors: Paoletti Isabella , Cedersund Elisabet , Economou Konstantin
Published: November 2023

Limitations are described in the literature in relation to the actual involvement of older people in action research activities. Empirical social research involving any form of data collection has an impact on the people and the setting studied. Researchers should strive to be morally aware of such an impact. The article describes case studies of participatory research in Sweden, Italy and Portugal. It highlights moral issues confronted by researchers. Moreover actual examples of different order of priorities among researchers and participants are provided. The study shows possible spaces for collaboration, while recognizing the difference of interests and priorities among researchers and participants.
Effect of robot-assisted gait training on motor dysfunction in Parkinson’s patients:A systematic review and meta-analysis
Authors: Jiang Xiaoyu , Zhou Jianpeng , Chen Qiang , Xu Qiling , Wang Shuting , Yuan Lin , Zhang Deqi , Bi Hongyan , Li Haixia
Published: November 2023

BACKGROUND: Robot-assisted gait training (RAGT) has been reported to treat motor dysfunction in patients with Parkinson’s disease (PD) in the last few years. However, the benefits of RAGT for treating motor dysfunction in PD are still unclear. OBJECTIVES: To investigate the efficacy of RAGT for motor dysfunction in PD patients. METHODS: We searched PubMed, Web of Science, Cochrane Library, Embase, CNKI, Wanfang, Chinese Biomedical Literature Database (CBM), and Chinese VIP Database for randomized controlled trials investigating RAGT to improve motor dysfunction in PD from the databases’ inception dates until September 1, 2022. The following outcome indexes were employed to evaluate motor dysfunction: the Berg Balance Scale (BBS), Activities-specific Balance Confidence Scale (ABC), 10-Meter Walk Test gait speed (10-MWT), gait speed, stride length, cadence Unified Parkinson Disease Rating Scale Part III (UPDRS III), 6-Minute Walk Test (6MWT), and the Timed Up and Go test (TUG). The meta-analysis was performed using the proper randomeffect model or fixed-effect model to evaluate the difference in efficacy between the RAGT and the control groups. The Cochrane Risk of Bias Tool was used for the included studies and Grading of Recommendations, Assessment, Development, and Evaluations (GRADE) was used to interpret the certainty of the results. RESULTS: The results consisted of 17 studies comprising a total of 670 participants. Six hundred and seven PD patients with motor dysfunction were included: 335 in the RAGT group and 335 in the control group. This meta-analysis results established that when compared with the control group, robot-assisted gait training improved the BBS results of PD patients (MD: 2.80, 95%CI: 2.11–3.49, P< 0.00001), ABC score (MD: 7.30, 95%CI: 5.08–9.52, P< 0.00001), 10-MWT (MD: 0.06, 95%CI: 0.03–0.10, P= 0.0009), gait speed (MD: 3.67, 95%CI: 2.58–4.76, P< 0.00001), stride length (MD: 5.53, 95%CI: 3.64–7.42, P< 0.00001), cadence (MD: 4.52, 95%CI: 0.94–8.10, P= 0.01), UPDRS III (MD: -2.16, 95%CI: -2.48–-1.83, P< 0.00001), 6MWT (MD: 13.87, 95%CI: 11.92–15.82, P< 0.00001). However, RAGT did not significantly improve the TUG test result of patients with PD (MD =-0.56, 95% CI: -1.12–0.00, P= 0.05). No safety concerns or adverse reactions among robot-assisted gait training patients were observed. CONCLUSION: Even though RAGT can improve balance function, walking function, and gait performance and has demonstrated positive results in several studies, there is currently insufficient compelling evidence to suggest that it can improve all aspects of lower motor function.
Influence of radiological factors, psychosocial factors, and central sensitization-related symptoms on clinical symptoms in patients with lumbar spinal canal stenosis
Authors: Ashida Yuzo , Miki Takahiro , Kondo Yu , Takebayashi Tsuneo
Published: November 2023

BACKGROUND: No study to date has concurrently evaluated the impact of radiological factors, psychosocial factors, and central sensitization (CS) related symptoms in a single lumbar spinal canal stenosis (LSS) patient cohort. OBJECTIVE: To investigate the associations between these factors and clinical symptoms in LSS patients. METHODS: We recruited 154 patients with LSS scheduled for surgery. Patient-reported outcome measures and imaging evaluation including clinical symptoms, psychosocial factors, CS-related symptoms, and radiological classifications. Spearman’s rank correlation coefficient and multiple regression analyses were employed. RESULTS: Spearman’s correlation revealed CS-related symptoms positively correlated with low back pain (r= 0.25, p< 0.01), leg pain (r= 0.26, p< 0.01), and disability (r= 0.32, p< 0.01). Pain catastrophizing positively correlated with leg pain (r= 0.23, p< 0.01) and disability (r= 0.36, p< 0.01). Regression analysis showed that pain catastrophizing was associated with disability (β= 0.24, 95%CI = 0.03–0.18), and CS-related symptoms with low back pain (β= 0.28, 95%CI = 0.01–0.09). Radiological classifications were not associated with clinical symptoms. CONCLUSION: Our findings suggest that psychosocial factors and CS-related symptoms, rather than radiological factors, seem to contribute to clinical symptoms in patients with LSS.
Efficacy of proprioceptive neuromuscular facilitation on functioning in patients with bilateral hip osteoarthritis: A pilot randomized controlled trial
Authors: de Sire Alessandro , Marotta Nicola , Spanó Riccardo , Fasano Stefano , Sgro Maria , Lippi Lorenzo , Invernizzi Marco , Ammendolia Antonio
Published: November 2023

BACKGROUND: Hip osteoarthritis (OA) is a chronic progressive disease that impresses a noticeable burden to society and healthcare systems. Physical exercise constitutes the first-line hip OA treatment approach, nevertheless, there is currently no gold standard method to treat this disease. OBJECTIVE: To evaluate the efficacy of proprioceptive neuromuscular facilitation (PNF) on functioning in patients with hip OA. METHOD: A pilot randomized controlled trial (RCT) was carried out on patients with painful bilateral hip OA with a body mass index (BMI) < 30 kg/m2. After the randomization, the experimental group was treated with PNF protocol and the control group with conventional physical therapy (10 sessions of manual therapy, 5 sessions/week for 2 weeks). The Harris Hip Score (HHS) was the primary outcome, whereas we assessed as secondary outcomes: pain, range of motion, and muscle strength of hip, physical performance, and quality of life. RESULTS: Twenty patients (40 hips) were enrolled and randomized into two groups: PNF group (mean age: 70.7 ± 8.07; BMI: 25.1 ± 3.07; 7 females and 3 males) and control group (mean age: 74.9 ± 10.72; BMI: 26.8 ± 3.78; 6 females and 4 males). The results showed a statistically significant improvement of HHS in the study group (T1: 90.6 ± 5.63) than in the control group (T1: 77.3 ± 10.9) (between-group p value < 0.001). Three months after the treatment we have statistically significant maintenance in the PNF group (T2:89.6±6.32, within-group ΔT0-T2 p< 0.01) while the control group did not maintain the improvements recorded at T1 (T2: 71.4 ± 15.8). CONCLUSION: The results of this pilot RCT showed that incorporating PNF exercises into the rehabilitation program yielded notable enhancements in improving lower limb function, strength and ROM in hip OA patients. Nonetheless, further prospective studies including wider sample size are needed to implement scientific knowledge on this physical therapy approach, in patients with hip osteoarthritis.
Long-chain noncoding RNA LINC01569 upregulates filamin A-interacting protein 1-like to prevent metastasis of triple-negative breast cancer via sponging miR-300
Authors: Jiang Xinyu , Lin Juli , Zhu Zhanlin
Published: November 2023

BACKGROUND:

Long-chain noncoding RNA (lncRNA), LINC01569, is important for regulating the extracellular matrix, which affects cell migration. However, its involvement in the occurrence and development of triple-negative breast cancer (TNBC) remains unclear.

OBJECTIVE:

This study is aimed to investigate the role of LINC01569 on TNBC.

METHODS:

Online database was used for clinical data analysis. Cell viability and migration capability were monitored using cell counting kit-8 and transwell assays, respectively. Luciferase reporter assay and RNA pull-down were used to confirm the binding capability between noncoding RNAs and filamin A-interacting protein 1-like (FILIP1L). Western blotting was used to determine the protein content.

RESULTS:

Compared with normal breast tissue, LINC01569 was significantly reduced in patients with TNBC subtype, and LINC01569 expression gradually decreased with the progression of tumor stage. Patients with TNBC with high lncRNA LINC01569 levels had a better prognosis than did patients with low LINC01569 levels. LINC01569 overexpression inhibited the migration capability, whereas siRNA-mediated LINC01569 downregulation promoted the migration capability in TNBC cells. Using ENCORI and lncRNA SNP online databases, miR-300 was screened as the potential sponge of LINC01569. The binding of LINC01569 to miR-300 was confirmed using the dual-luciferase reporter and RNA pull-down assays. miR-300 was negatively correlated with LINC01569, and miR-300 mimics eliminated the anti-proliferation and anti-migration effects of LINC01569 on TNBC cells. Additionally, FILIP1L was further verified as the downstream target of miR-300. miR-300 mimics blocked LINC01569 upregulation-mediated elevation of FILIP1L. Importantly, the anti-tumor effects mediated by LINC01569 overexpression were abolished by miR-300 mimics and further restored by FILIP1L upregulation.

CONCLUSIONS:

LINC01569 was expressed at a low level in TNBC and could sponge miR-300 to promote FILIP1L expression, reducing the proliferation and metastasis capability of TNBC. Thus, LINC01569 might be a useful biomarker in the diagnosis and prognosis of metastatic TNBC.
An in-depth study on key nodes in social networks
Authors: Sun Chengcheng , Wang Zhixiao , Rui Xiaobin , Yu Philip S. , Sun Lichao
Published: November 2023

In social network analysis, identifying the important nodes (key nodes) is a significant task in various applications. There are three most popular related tasks named influential node ranking, influence maximization, and network dismantling. Although these studies are different due to their own motivation, they share many similarities, which could confuse the non-domain readers and users. Moreover, few studies have explored the correlations between key nodes obtained from different tasks, hindering our further understanding of social networks. In this paper, we contribute to the field by conducting an in-depth survey of different kinds of key nodes through comparing these key nodes under our proposed framework and revealing their deep relationships. First, we clarify and formalize three existing popular studies under a uniform standard. Then we collect a group of crucial metrics and propose a fair comparison framework to analyze the features of key nodes identified by different research fields. From a large number of experiments and deep analysis on twenty real-world datasets, we not only explore correlations between key nodes derived from the three popular tasks, but also summarize insightful conclusions that explain how key nodes differ from each other and reveal their unique features for the corresponding tasks. Furthermore, we show that Shapley centrality could identify key nodes with more generality, and these nodes could also be applied to the three popular tasks simultaneously to a certain extent.
Note-level singing melody transcription with transformers
Authors: Park Jonggwon , Choi Kyoyun , Oh Seola , Kim Leekyung , Park Jonghun
Published: November 2023

Recognizing a singing melody from an audio signal in terms of the music notes’ pitch onset and offset, referred to as note-level singing melody transcription, has been studied as a critical task in the field of automatic music transcription. The task is challenging due to the different timbre and vibrato of each vocal and the ambiguity of onset and offset of the human voice compared with other instrumental sounds. This paper proposes a note-level singing melody transcription model using sequence-to-sequence Transformers. The singing melody annotation is expressed as a monophonic melody sequence and used as a decoder sequence. Overlapping decoding is introduced to solve the problem of the context between segments being broken. Applying pitch augmentation and and adding noisy dataset with data cleansing turns out to be effective in preventing overfitting and generalizing the model performance. Ablation studies demonstrate the effects of the proposed techniques in note-level singing melody transcription, both quantitatively and qualitatively. The proposed model outperforms other models in note-level singing melody transcription performance for all the metrics considered. For fundamental frequency metrics, the voice detection performance of the proposed model is comparable to that of a vocal melody extraction model. Finally, subjective human evaluation demonstrates that the results of the proposed models are perceived as more accurate than the results of a previous study.
Performance analysis of deep transfer learning approaches in detecting and classifying brain tumor from magnetic resonance images
Authors: Deepa P.L. , Narain P.D. , Sreena V.G.
Published: November 2023

The Central Nervous System (CNS) is one of the most crucial parts of the human body. Brain tumor is one of the deadliest diseases that affect CNS and they should be detected earlier to avoid serious health implications. As it is one of the most dangerous types of cancer, its diagnosis is a crucial part of the healthcare sector. A brain tumor can be malignant or benign and its grade recognition is a tedious task for the radiologist. In the recent past, researchers have proposed various automatic detection and classification techniques that use different imaging modalities focusing on increased accuracy. In this paper, we have done an in-depth study of 19 different trained deep learning models like Alexnet, VGGnet, DarkNet, DenseNet, ResNet, InceptionNet, ShuffleNet, NasNet and their variants for the detection of brain tumors using deep transfer learning. The performance parameters show that NASNet-Large is outperforming others with an accuracy of 98.03% for detection and 97.87% for classification. The thresholding algorithm is used for segmenting out the tumor region if the detected output is other than normal.
Association of Vitamin E and Cognitive Decline in Older Adults with and without the APOEɛ4 Allele: A Biracial Population-Based Community Study
Authors: Liu Xiaoran , Finno Carrie J. , Beck Todd , Dhana Klodian , Tangney Christy , Desai Pankaja , Krueger Kristin , Evans Denis A. , Rajan Kumar B.
Published: November 2023

Background:

The association of different types of tocopherols (vitamin E) with cognition might vary by the APOE ɛ4 allele status.

Objective:

We examined the association of dietary tocopherols with cognitive decline among participants with and without the APOE ɛ4 allele over a median of 12 years.

Methods:

2,193 participants from the Chicago Health and Aging Project were included in the analyses. Global cognition was assessed in three-year cycles. We used a 144-item FFQ to assess dietary intakes of tocopherols and hME Sequenom mass-array platform to assess APOE genotype. We used linear mixed effects models to examine the relationship between tocopherol from food sources and global cognitive decline.

Results:

The mean baseline age was 74.1 (SD = 5.9) years. Among APOE ɛ4 carriers, participants in the highest quintile of intakes of dietary vitamin E had a slower cognitive decline of 0.022 SDU (95% CI: 0.000, 0.043) compared to those in the lowest quintile. A higher intake of dietary α-tocopherol from food sources only was associated with slower cognitive decline in APOE ɛ4 carriers (p for trend 0.002) but not among the non-carriers (p for trend 0.937). Among APOE ɛ4 carriers, those in the highest quintile of intake of α-tocopherol had a 16.4% slower rate of decline of global cognition compared to those in the lowest quintile (β= 0.034, 95% CI: 0.013, 0.054).

Conclusions:

Individuals consuming high α-tocopherol from food sources had slower cognitive decline among APOE ɛ4 carriers. In older adults, different forms of vitamin E might moderate the relationship of APOE ɛ4 with global cognition.
Relationship between ICD implantation volume and treatment parameters of patients receiving an ICD with remote monitoring
Authors: Butter Christian , Klein Gunnar , Grönefeld Gerian , Böcker Dirk , Suling Anna , Buchholz Anika , Felk Angelika , Hauser Tino , Wegscheider Karl , Bänsch Dietmar
Published: November 2023

BACKGROUND: Both highly specialized heart centres and less specialized hospitals care for patients with implantable ICDs/CRT-Ds with remote monitoring. OBJECTIVE: To investigate potential differences in patient treatment according to centre’s ICD implantation volume. METHODS: Based on their 2012 ICD/CRT-D implantation volume, centres enrolled in the NORDIC ICD trial in Germany were assigned to one of three groups: high- (HV, n= 345), medium- (MV, n= 340) or low-volume (LV, n= 189). RESULTS: The HV-centres had a significant higher CRT-D proportion (41.7%; LV: 36.5%; MV: 23.2%; P𝑔𝑙𝑜𝑏𝑎𝑙< 0.001), significant shorter median procedure duration (49 min; MV: 58 min; LV: 60 min; P𝑔𝑙𝑜𝑏𝑎𝑙< 0.001) but significant longer median hospital stay (4 days; MV and LV: 3 days; P𝑔𝑙𝑜𝑏𝑎𝑙< 0.001) compared to MV- and LV-centres. The X-ray exposure was shorter in MV/HV-centres (MV: 3.4 min; HV: 3.6 min; LV: 5.5 min; P𝑔𝑙𝑜𝑏𝑎𝑙< 0.001). Only 3.5% (LV: 2.6%; HV: 3.5%; MV: 4.1%) patients received at least one delivered inappropriate shock and 2.5% (HV: 2.0%; LV: 2.6%; MV: 2.9%) patients had withheld inappropriate ICD shocks without subsequent inappropriate shock delivery within 24.5 months of median follow-up. CONCLUSION: Implantation volume-dependent differences were observed in the device selection, procedure duration and x-ray exposure duration. Remote monitoring in combination with adequate response pattern prevented imminent inappropriate shocks in all three groups.
Exploring the impact of body mass change on fatigue and activity of the muscular system during daily routine
Authors: Zadoń Hanna , Michnik Robert , Nowakowska-Lipiec Katarzyna
Published: November 2023

BACKGROUND: Correct body weight is one of the factors that allows you to maintain a properly functioning body. Abnormal body weight can cause muscle tissue remodelling, affecting activity and muscle fatigue. Changes in the muscular system can cause occurrence of functional limitations. OBJECTIVE: To determine the effect of weight change on fatigue and activity of the muscular system during daily activities. METHODS: The evaluation of musculoskeletal functioning was based on the results of computer simulations conducted in the AnyBody Modeling System. The following activities were analysed: standing, sitting down and getting up from a chair, holding and lifting an object, and walking. The simulations of the activities were carried out using averaged kinematic data, and by changing body mass in the range of 50 kg to 100 kg by increments of 2 kg, to map different nutritional status from excessive thinness to extreme obesity. Identification of loads in the musculoskeletal system was based on solving an inverse dynamics problem and then the estimation of muscle force values using static optimization. The simulation results allowed to determine the value of muscle fatigue and the level of muscle activity. RESULTS: For activities (i.e., standing, walking, sitting down and getting up from a chair) it was observed that the value of muscle fatigue increases with increasing body mass. However, for activities that cause more load on the musculoskeletal system, i.e. lifting and holding an object, the highest value of muscle fatigue was observed in underweight individuals. CONCLUSION: The change in body weight alters the functioning of the muscular system and thus the ability to perform activities. It was shown that in case of underweight, overweight or obese people, abnormal body weight can be the reason for occurrence of difficulties in performing the activities of lifting and holding a 20 kg object, as well as walking.
Does Sugar Control Arrest Complications in Type 2 Diabetes? Examining the Rigour in Statistical Methods and Causal Inference in Clinical Trials
Authors: Ojha Akankasha , Vidwans Harshada , Watve Milind
Published: November 2023

BACKGROUND: In contrast to type 1 diabetes mellitus (T1DM), in type 2 (T2DM) the success of intensive glucose normalisation in arresting diabetic complications is marginal and inconsistent across multiple clinical trials. However, glucose regulation still largely remains the main target of treatment for T2DM in clinical practice.

OBJECTIVES: We examine the possible causes of inconsistency across studies, the scientific rigour behind the design, conduct and inferences of 6 large institutional clinical trials targeting glucose normalisation and following up for diabetic complications and mortality.

STUDY DESIGN: We enumerate the possible flaws in the design, statistical treatment of the results and possible logical traps in making inferences. Further, we evaluate whether the flaws can mislead the conclusions. We also suggest a more sound statistical treatment of the data and interpret results of the trials together in a coherent way.

RESULTS: The clinical trials for intensive glucose control suffer from a number of common problems that have not been addressed. The most important being the failure to correct for multiple outcomes. This is recognised by some reviewers but no correction is attempted. The second is the interdependence of the outcomes, owing to which statistics based on the assumption of independence can be misleading. Simulations show that the apparent inconsistency or heterogeneity between trial results can be explained by the violation of assumed independence alone. Further, the problems with placebo control, failure to recognise alternative possibilities, inability to segregate clinical significance from statistical significance and misleading reporting formats point to conformity bias and publication bias.

CONCLUSIONS: We find no support for the prevalent belief that glucose normalisation has any benefit in terms of reducing the frequency of any of the complications or mortality. It is time to reconsider the glucocentric line of treatment of T2DM. Rethinking some of the fundamental beliefs about the pathophysiology of diabetic complications and facilitating novel alternative lines of research is the need of the field.
Effectiveness of Mingle Game to Develop Students' Speaking Skills at SMPN 1 Indramayu
Authors: Novitasari Dian , Prawiro Indra Yoga
Published: November 2023

People need to talk to communicate with others by sharing their thoughts, ideas and feelings. Speaking is one of the most important language skills in learning English. Unfortunately, students find it difficult to express what they think using English including inhibition, inability to speak, low or uneven participation, and excessive use of mother tongue. Therefore, one of the games that can be used to teach speaking is the Mingle game. This study aims to determine the effectiveness of the mingle game in developing students' speaking skills. This research used a quantitative design.
STUDENTS' PERCEPTION OF THE FLIPPED MODEL BLENDED LEARNING IN EFL CLASSROOM
Authors: Wati Atikah , Fauzi Ajeng Bella Septi
Published: November 2023

The educational sector in the post-pandemic era, due to the COVID-19 crisis, forces teachers to adapt to new methodologies and instructions in teaching students in EFL classrooms. One of the learning methods used is the flipped model of blended learning. This study aims to determine how the students perceive the learning experience after using the flipped blended learning model in EFL classrooms at the Vocational High School level. That focuses on investigating the students' perception of flipped model blended learning in terms of motivation, Effectiveness, and Engagement. This study used Qualitative research with a case study design. Ten items of a close-ended questionnaire were used as the instrument. The data was then calculated using the Likert Scale. The findings show that students at Losarang Vocational High School had a positive view of motivation, Effectiveness, and Engagement. Specifically, the result of students' perceptions of motivation was 3,11, Effectiveness was 3,31, and EngagementEngagement was 3,27. The students agreed that the flipped model of blended learning improves their learning process. When the students spent more time learning using flipped blended learning, they became more engaged since they had the flexibility to arrange their studies as they see best, wherever and whenever. Students received the flipped model of blended learning in EFL classrooms positively.
ОЦІНКА СПРОМОЖНОСТІ ГРОМАД ТА РАЙОНІВ ДОНЕЦЬКОЇ ТА ЛУГАНСЬКОЇ ОБЛАСТЕЙ
Authors: Плєтньов Михайло Васильович , Вахлакова Вікторія Володимирівна
Published: November 2023

Due to the intensification of hostilities in eastern Ukraine in 2022 and the occupation of Luhansk and part of Donetsk oblasts, the issue of assessing and building the capacity of communities and districts has become more relevant. This is due to the fact that the assessment is influenced by many factors, including the geographical location of the community and the presence/absence of hostilities. The purpose of the article is to substantiate proposals for increasing the capacity of territorial communities and districts of Donetsk and Luhansk oblasts due to the war. Methods used in the study: comparative analysis, detailing and generalisation, grouping. The hypothesis of the study was the assumption that the decline in the capacity of territorial communities affects the change in the capacity of districts of Donetsk and Luhansk regions, which should also be assessed. Summary of the main material.To substantiate the proposals for improving the capacity of territorial communities and districts of Donetsk and Luhansk oblasts, the results of a comparative analysis of the indicators of the capacity of communities in Donetsk and Luhansk oblasts, taking into account pre-war and war realities, were used. On the basis of the results obtained, the matrix of alternative proposals for improving their capacity is formed. The capacity of the districts of Donetsk and Luhansk oblasts in 2021 and 2022/2023 is determined. The originality and practical significance of the study lie in the proposals developed to increase the capacity of territorial communities and districts of Donetsk and Luhansk regions. Conclusions and prospects for further research. Based on the results of the conducted research, a matrix of eventual proposals for the territorial communities of Donetsk and Luhansk regions was built and the capacity of the districts of Donetsk and Luhansk regions in 2021 and 2022/2023 was determined. It is noted that the Luhansk region is almost entirely occupied, and in the Donetsk region, part of the territory is occupied, and in another part of the territory, the production and social infrastructure has been destroyed (and is being destroyed). Therefore, according to the results of the district capacity assessment, no district was identified as capable. Further research is needed to substantiate the reconfiguration of territorial communities and districts in the East of Ukraine in the post-war period.
МОНІТОРИНГ РЕГУЛЮВАННЯ СОЦІАЛЬНО-ЕКОНОМІЧНОГО ВІДТОРГНЕННЯ НА ПІДПРИЄМСТВАХ В УМОВАХ ФІНАНСОВОЇ ТУРБУЛЕНТНОСТІ
Authors: Ліхоносова Ганна Сергіївна
Published: November 2023

Formulation of the problem. The presented study contains the author's vision of the main aspects and approaches to the regime of monitoring the regulation of socio-economic rejection at enterprises in the conditions of post-war economic instability and financial turbulence. The purpose of the study is to analyze the trends and risks of lack of regulation and leveling of socio-economic rejection in the conditions of post-war economic instability in the context of systematization of modern provisions and concerns of leading financiers regarding the probability of a global financial recession. Scientific publications and monographic editions, magazine articles and materials of scientific and practical conferences became the methodological basis of the research. Content analysis of scientific periodicals was used during the research; comparative critical analysis of existing approaches and methods of analysis of financial stability and tax burden; analysis of economic activity of enterprises in the aerospace industry; statistical methods of analysis. The main hypothesis of the study was the assumption of the possibility of leveling social and economic rejection at enterprises due to the introduction of the latest financial and economic technologies of digital transformation and restoration of the production potential of Ukraine. Presenting main material. In the course of the study, it was established that actions aimed at regulating socio-economic rejection in the conditions of post-war economic turbulence can be measured by a set of indicators capable of reflecting the existing state of security factors. The results of the study proved that the transformational processes associated with the use of digital technologies entail the possibility of risks and threats to the financial stability of entrepreneurship. It is proposed to use certain types of technologies to regulate socio-economic rejection in post-war conditions of economic turbulence. The originality and practical significance is defined in the interpretation of the essence and components of the entropy balance of the enterprise, which determines the level of risk of rejection at the enterprise; determination of systemic action factors (the level of enterprise metabolism, the degree of immersion in the socio-economic space, the efficiency of using time lags, the elimination of growing entropy, self-development and homeostasis), the implementation of which can eliminate or neutralize rejection and ensure the perfection of the enterprise's systemic positioning. Conclusions and prospects for further research. Procedures for monitoring the regulation of socio-economic rejection at enterprises are presented, which are distinguished by a time lag from the detected rejection to the implementation of appropriate regulatory actions, which allows the management to make adequate management adjustments in accordance with the available financial resources
НАПРЯМИ ІНВЕСТИЦІЙНОГО-ІННОВАЦІЙНОГО РОЗВИТКУ АГРАРНОГО ВИРОБНИЦТВА УКРАЇНИ В УМОВАХ ЄВРОІНТЕГРАЦІЙНИХ ЗМІН ТА ПРОДОВОЛЬЧИХ ВИКЛИКІВ
Authors: Зоря О.П. , Зоря С.П. , Мауер Д.Р.
Published: November 2023

У статті наведено можливості розвитку аграрного сектору України в євроінтеграційних процесах, зокрема з метою поліпшення стану продовольчої безпеки та досягнення цілей сталого розвитку, адже вони охоплюють ключові фактори, що стимулюють розвиток сільського господарства, зокрема шляхом інвестиційно-інноваційної активності в різних галузях аграрної сфери. Здійснено аналіз оцінок продовольчої безпеки України за показниками фізичної доступності продовольства, визначено місце країни у загальному рейтингу Глобального індексу продовольчої безпеки, проведено порівняння показників фізичної доступності з середніми значеннями країн Європи та середнього значення усіх 113-ти досліджуваних країн світу. Визначено негативні аспекти в оцінці стану продовольчої безпеки країни, пов’язані з розвитком інфраструктури ланцюгів поставок, політичними й соціальними бар’єрами доступу, зокрема ризики збройного конфлікту і поширення корупції та запропоновано шляхи їх нівелювання.
ТЕОРЕТИКО-МЕТОДОЛОГІЧНІ ЗАСАДИ ФОРМУВАННЯ ІНВЕСТИЦІЙНОЇ ПОЛІТИКИ ПІДПРИЄМСТВА
Authors: Зоря О.П. , Яснолоб І.О. , Аранчій Д.С.
Published: November 2023

У статті здійснено розробку й обґрунтування теоретико-методологічних та науково-методичних засад формування інвестиційної політики підприємства в умовах трансформації зовнішнього середовища. Проведено розробку методів та інструментів формування інвестиційної політики на мікро- та макрорівні. Встановлено, що інвестиційна політика може бути представлена як невід’ємна частина системи вищого рівня, або як загальна система зі своєю власною внутрішньою структурою. Зазначено, що інвестиційну політику варто сприймати як форму економічної політики, яка включає контроль і регулювання всіх аспектів інвестиційного процесу: структури інвестиційних фондів, ефективності, їх розміру і джерел. Відповідно до критерію ризикових переваг інвестора, розглядаються три типи інвестиційної політики підприємства: агресивна, помірна, консервативна. У статті пропонується запровадити новий тип інвестиційної політики – прискорено-агресивний. У роботі зазначено, що конкретний зміст інвестиційної політики підприємства обумовлюється впливом факторів зовнішнього та внутрішнього середовища, специфічними рисами виробництва та управління. У якості елементів системи управління інвестиційною політикою підприємства виділено принципи, методи та структуру управління.
АКТУАЛІЗАЦІЯ ПРОЦЕДУРИ ФОРМУВАННЯ ФІНАНСОВИХ РЕСУРСІВ ПІДПРИЄМСТВА В УМОВАХ ЦИФРОВОЇ ЕКОНОМІКИ
Authors: Халатур С.М. , Строцький В.В.
Published: November 2023

У статті розкриваються основні принципи управління фінансовими ресурсами підприємств в умовах функціонування цифрової економіки України і світу. Авторами висвітлено основні складові механізму управління фінансовими ресурсами підприємств. Проведено огляд найбільш відомих підходів до визначення характеристик фінансових ресурсів підприємства, який показав багатомірність і різноплановість теоретичних і практичних поглядів на цю економічну категорію. Запропоновано узагальнений вигляд економічної категорії «фінансові ресурси» підприємств, який відображає його основні характеристики як елементу фінансового менеджменту підприємства. Розглянуто принципи ефективного управління фінансовими ресурсами підприємства, що забезпечується реалізацією поставлених перед ним завдань і мети. Визначено основоположні аспекти системи управління фінансовими ресурсами підприємства як складової фінансового менеджменту.
Pengaruh Fungsi Badan Pengawas, Kualitas Sumber Daya Manusia Dan Pemanfaatan Teknologi Informasi Terhadap Kualitas Laporan Keuangan Pada Lembaga Perkreditan Desa Se- Kota Denpasar
Authors: Mariani Ni Putu , Yuniasih Ni Wayan , Yeni Yuliantari Ni Putu
Published: November 2023

Quality financial reports are very important for LPD  to be able to assist in making decisions regarding their operations. This study intend to determine the function of the supervisory agency, the quality of human resources and the use of information technology on the quality of financial reports. The population in this study were 175 employees in 35 LPDs in Denpasar City, consisting of the LPD Chair, Secretary, and Supervisory Agency. The sampling technique in this study used is jenuh sampling method. The results showed that the variables of the function of the supervisory agency, the quality of human resources and the use of information technology had a significant positive effect on the quality of financial reports at the Village Financial Institutions (LPD) City. 

 Keyword: The Influence of Supervisory Agency, Quality of Human Resources and Information Technology on Quality Financial Reports.
Peranan Risk Based Audit Pada Bagian Kredit Dalam Mengevaluasi Proses Kredit
Authors: Ratih Gusti Ayu Kade , Cita Ayu Putu
Published: November 2023

This study aims to determine how the application of Risk-Based Audit on the credit department of PT. BPR Bank Kertiawan in order to improve the efficiency and effectiveness of the entity's internal audit. The results showed that the key business process credit at PT. BPR Bank Kertiawan which has a high risk is the Credit Analysis section which affects the credit take over process and the making of a Credit Agreement and its supporting documents so that for further examination, SKAI will focus on the Credit Analysis section which has a high inherent risk