bluuebunny/crossref_metadata_2025 huggingface dataset:
A Study of Mathematical Formulation on Algebras of Partial Functions
Authors: Neha Neha , Jakhar Manjeet Singh
Published: February 2025

Throughout mathematics, numerical approximation is studied in this topic; functions are far more common than relations, which are more generic. But things have always been backwards when it comes to the mathematics of reasoning about these things. At first, the goal of this effort was rigorous algebraic logic. To rephrase, the relations were supplying the meaning to the logical expressions. Since functions are not well-suited to the duty of analyzing formula semantics, this may explain why the related theory of functions remained underdeveloped until recently. On the other hand, computer science has emerged as a driving force in relational history, with binary relations serving as the semantic foundation for (nondeterministic) computer programs in particular. As this perspective sees it, the relation connects the dots between the machine's possible states before and after program execution.
Challenges Faced By Female Students With Disabilites In Higher Education: An Exploratry Study Of The Socio-Economic Perspective
Authors: Ojha Mukta
Published: February 2025

This study explores the multifaceted challenges encountered by female students with disabilities in higher education, emphasizing socio-economic perspectives. Utilizing secondary data sources, the research delves into barriers related to accessibility, financial constraints, societal attitudes, and institutional support mechanisms. The analysis reveals that female students with disabilities often face compounded disadvantages due to gender and disability, impacting their academic performance, social integration, and future employment prospects. The findings underscore the need for comprehensive policy interventions, enhanced support services, and a paradigm shift towards inclusive education to mitigate these challenges. This exploratory study contributes to the broader discourse on equity in higher education, advocating for strategies that address both gender and disability-related disparities.
Edge Computing vs. Cloud Computing: Complementary or Competitive
Authors: Deepak Deepak
Published: February 2025

The rapid evolution of technology has given rise to edge and cloud computing as pivotal paradigms in modern IT infrastructure. Both approaches offer unique advantages, addressing distinct challenges in processing, storage, and data analysis. This paper explores the fundamental principles of these paradigms offer distinct advantages that cater to varying requirements in processing, storage, and data analysis. Cloud computing excels in delivering scalable and centralized solutions for extensive data processing and storage needs. In contrast, edge computing addresses the increasing demand for low-latency, real-time data processing by bringing computation closer to the data source. This paper examines the core principles, use cases, and technological trends of both paradigms, assessing whether they function as complementary technologies or competitors. Through an in-depth analysis of real-world applications, challenges, and opportunities, this study sheds light on the dynamic interplay between edge and cloud computing, compares their functionalities, and evaluates whether they operate as complementary technologies or compete for dominance in various application domains. By examining real-world use cases and technological trends, this study provides insights into the future interplay between edge and cloud computing. The findings underscore that, while they can compete in specific domains, their true potential lies in their synergy, enabling hybrid solutions that optimize performance, cost, and scalability in diverse sectors such as IoT, healthcare, autonomous systems, and smart cities.
Arithmetic Progression and Binary Recurrence
Authors: Chugh Rupali , Neelam Neelam
Published: February 2025

Chalcogenide photonic crystal fibers (PCFs) have emerged as a transformative platform for sensing applications, particularly in the mid-infrared (mid-IR) spectral range. The unique optical properties of chalcogenide glasses, including a broad transparency window (2–16 μm), high refractive index, and exceptional nonlinear coefficients, make them ideal for detecting molecular vibrational signatures in this region. This review synthesizes recent advancements in the field, covering the material properties and fabrication techniques of chalcogenide PCFs, their sensing mechanisms, and applications. Key sensing methods, such as evanescent wave spectroscopy and stimulated Brillouin scattering, are explored, alongside innovative strategies like tapering, dispersion engineering, and microstructuring to optimize performance. Challenges in fabrication, environmental stability, and scalability are critically examined, with an emphasis on ongoing efforts to address these limitations. Finally, the paper highlights future directions for enhancing the reliability, scalability, and commercial viability of chalcogenide PCF-based sensors. The versatile design flexibility and exceptional material properties of chalcogenide PCFs position them as a promising technology for advancing sensing applications across diverse fields, including environmental monitoring, biomedical diagnostics, and industrial process control.
Analisis Faktor-Faktor yang Mempengaruhi Pendapatan Nelayan di Desa Dongkala Kabupaten Buton
Authors: Abdul Hadi Bone
Published: February 2025

The coastal and marine areas in Dongkala village are areas that have the potential to provide various benefits to support community survival. This research aims to determine the factors that influence fishermen’s income. The research was carried out in Dongkala village, Buton regency starting from October to November 2023. The research method used quantitative descriptive methods, multiple linear regression analysis models with the help of SPSS v.17.0 software. The sample used was 50 fishermen respondents who were determined using a purposive sampling technique. The results of research partially show that capital, experience, fish prices and education level have a significant effect on fishermen’s income, while simultaneously the variables of fish price, and education level have a significant effect on fishermen’s income in Dongkala village, Buton regency. The policy that needs to be taken from the results of this research is to optimize the ship operational assistance program for fishermen in order to increase the number of catches, the impact of which will provide regional income levels.
Sosialisasi Pentingnya Menjaga Kebersihan Lingkungan Pantai Kepada Masyarakat Pesisir Guna Menjaga Kelestarian Ekosistem Pantai Payangan
Authors: Afni Nur Rosyidah  , Inge Wiliandani Setya Putri  , Arik Aguk Wardoyo  , Hilda Eka Ningtyas  , Faiqotul Munawaroh
Published: February 2025

Maintaining a clean environment is of course very important, especially for people who live in areas around the beach. However, several beaches in Jember still tend to be littered with rubbish, thus disrupting the sustainability of the coastal ecosystem. This research aims to provide outreach about the importance of keeping the coastal environment clean so that coastal communities can maintain the sustainability of coastal ecosystems through waste management education. In this case, it is outreach to the community around Payangan beach. This service method is the PAR (Participatory Action Research) service method. The data collection technique uses a qualitative approach technique which includes surveys, interviews, and documentation analysis. The research results show that outreach involving the active participation of the community, stakeholders and local government has had a positive impact in increasing awareness of the importance of keeping beaches clean. This outreach includes correct waste management including reduction, recycling, and safe disposal. It was concluded that there is a need for continued support from the government and non-governmental organizations to implement broader and more sustainable outreach programs to preserve coastal ecosystems in the future.
Aplicación de parche de capsaicina al 8% (Qutenza®) para el manejo del dolor neuropático postoracotomía
Authors: Esteban Sánchez Maria , Martínez Redondo Eva , Sanjurjo Morote Marina , Santos Cabezas Purificación
Published: February 2025

El dolor neuropático es complejo y de difícil tratamiento. En este caso clínico se presenta a un varón de 53 años diagnosticado de un nódulo pulmonar sospechoso de malignidad y al que realiza una segmentectomía atípica en lóbulo superior izquierdo y biopsia ganglionar por toracoscopia.
A la exploración física presenta una cicatriz quirúrgica con buen aspecto, sin signos inflamatorios ni trastornos tróficos. Sensación de alodinia e hiperalgesia intensa en la zona de la minitoracotomía. Tras comprobar ineficacia de otros tratamientos, se propone el parche de capsaicina al 8 % (Qutenza).
Únicamente presentó como efecto secundario leve piel eritematosa acompañada de calor, sensación de quemazón que se trató con frío local y prurito intenso.
Refiere inicio del alivio del dolor a los 4 días mejorando tanto la intensidad del dolor como el área de alodinia, que se redujo un 70% a los 7 días y de un 90% a las dos semanas. Al mes el dolor ha desaparecido en su totalidad.
A pesar de que en un principio el coste del parche de capsaicina al 8% es muy superior frente a los tratamientos orales clásicos, debemos considerar utilizar el parche como primera elección en el DNP localizado postoracotomía por su alta efectividad y los mínimos efectos secundarios.
Comparative study of in vitro biofilm formation with the innovative T-Control® catheter
Authors: Luque González Manuel , Mòdol Vidal Max , Armas Moreno Clara , Castellano Santana Pedro Raúl , Serrano Muñoz Marta , García Mendieta Jorge Saúl
Published: February 2025

This study aims to analyse in vitro biofilm formation for up to 3 and 5 days, comparing the new T-Control® catheter with a conventional Foley-type catheter. Using a vertical system, an E. coli strain was injected through the distal part of the catheters. The biofilm formed on the catheters was analysed at: 2h, 4h, 24h, 48h, and 72h in the 3-day study; and 2h, 24h, and 5 days in the 5-day study. In both studies, the biofilm formation was analysed by calculating the CFU in agar. Scanning Electron Microscope (SEM) was also visualised in the 3-day study. Biofilm formation was only slightly observed on the 5th day of the 5-day experiment for T-Control®. For the Foley-type catheter, biofilm was observed in the 5-day study at t=24h and t=5th day; and at times t=48h and t=72h in the 3-day study. The new T-Control® catheter could prevent or delay the formation of E. coli biofilm.
“共同缔造理念”下的乡村教育发展
Authors: 张钰杰
Published: February 2025

2022年5月，中共中央办公厅发布《乡村建设行动实施方案》，正式以中央文件形式提出“共同缔造”这一概念其中“共”是核心和灵魂，通过调动多方协同共创，促进成果共享，共同缔造美好生活。在这一思想理念的引领下，乡村振兴有条不紊推进，乡村生活环境和组织建设都有了一定程度的进步，但乡村居民关心的教育落后问题依然存在。
السرية المصرفية في لبنان بين الخصوصية ومكافحة الفساد
Authors:   دكتوراه: قانون الأعمال – القانون الخاص / الجامعة الإسلامية في لبنان, أبو زيد يسره أحمد ,   دكتوراه: القانون الجزائي – القانون العام / الجامعة اللبنانية
Published: February 2025

تُعد المصارف من المؤسسات الأساسية التي لا غنى عنها في الاقتصاد الحديث، حيث تلعب دورًا حيويًا في دعم النمو الاقتصادي على المستويين الوطني والعالمي. تعمل المصارف على جمع المدخرات من الأفراد وتوفير التسهيلات المالية اللازمة للمشاريع الاقتصادية المتنوعة، مما يعزز التنمية المستدامة ويوفر فرص العمل. في هذا السياق، نشأت السرية المصرفية كضرورة أساسية لحماية المعلومات الشخصية للعملاء، والتي تعتبر من الالتزامات الرئيسية للمصارف. يتطلب هذا الالتزام عدم الكشف عن تفاصيل الحسابات والمعاملات المالية إلا بموافقة العميل أو في حالات قانونية استثنائية.
شكلت السرية المصرفية حجر الزاوية في بناء الثقة بين المصرف وعملائه، مما يعزز الاستقرار المالي ويشجع على جذب الاستثمارات. ومع ذلك، يتطلب الحفاظ على هذه السرية تحقيق توازن دقيق بين حماية خصوصية الأفراد وتعزيز الشفافية لمكافحة الأنشطة غير القانونية مثل غسل الأموال والتهرب الضريبي. تحقيق هذا التوازن هو تحدٍ رئيسي يواجه المصارف، حيث يتعين عليها أن توازن بين التزاماتها تجاه الحفاظ على سرية المعلومات ومقتضيات الشفافية المطلوبة لتعزيز النزاهة المالية وحماية النظام الاقتصادي.
بناءً على ذلك، يسعى البحث إلى دراسة الأسس القانونية للسرية المصرفية وحدودها وفهم كيفية تأثير السرية المصرفية على الثقة بالنظام المالي وعلى مكافحة الفساد. مستعرضاً التحديات المتعلقة بسرية المعلومات وكيفية استغلالها لتسهيل الأنشطة غير القانونية. يهدف البحث إلى تقييم فعالية السياسات الحالية، وتقديم توصيات ومقترحات لإصلاحات قانونية ورقابية لتحقيق توازن بين حماية الخصوصية وتعزيز الشفافية، مما يعزز استقرار النظام المصرفي ويحد من مخاطر الفساد.
التلوث البيئي مسؤولية دولية
Authors:   دكتوراه قانون خاص / الجامعة الاسلامية في لبنان, الحسن حامد عبد الله إبراهيم , ناصيف البروفيسورة / نادين ,   الجامعة اللبنانية
Published: February 2025

يتناول هذا البحث قضية التلوث البيئي كمسؤولية دولية في إطار القانون الدولي و يركز البحث على أن التلوث البيئي لم يعد مشكلة محلية، بل أصبح تهديدًا عالميًا يتطلب استجابة دولية منسقة، يتناول البحث الجوانب القانونية المتعلقة بتحديد المسؤولية الدولية عن الأنشطة التي تؤدي إلى تلوث بيئي عابر للحدود، مثل انبعاثات الغازات الدفيئة، تسرب النفط، والتخلص غير الآمن من النفايات الخطرة.
كما يُبرز البحث أهمية المبادئ القانونية الدولية مثل مبدأ «الملوث يدفع»، ومبدأ «الاحتراس الوقائي»، ودور الاتفاقيات الدولية مثل اتفاقية الأمم المتحدة الإطارية بشأن تغير المناخ (UNFCCC) واتفاقية بازل
كما يناقش التحديات التي تواجه تنفيذ هذه القوانين، بما في ذلك نقص التعاون بين الدول، الأولويات الاقتصادية، وعدم وجود آليات إنفاذ قانونية فعالة.
ويخلص البحث إلى أن معالجة التلوث البيئي تتطلب تعزيز التعاون الدولي، تحديث التشريعات الوطنية والدولية، وتطبيق مبدأ العدالة البيئية بشكل أكثر صرامة كما يدعو إلى دور أكبر للمنظمات الدولية والمجتمع المدني في مراقبة الأنشطة الضارة بالبيئة وضمان الامتثال للقوانين البيئية.
Brain Tumor Classification and Segmentation Using Transfer Learning from MRI Images
Authors: Konduru Reddy Madhavi  , Kommanaboyina Lakshmi Sundara Soujanya  , Rambabu Inaganti  , Kondru Ayyappa Swamy  , Sreekanth Yalavarthi  , Madhu Munagala
Published: February 2025

Manual diagnosis of tumors on magnetic resonance images (MRIs) entails more time and doing so increases the risk of human error and incorrect tumor type identification and classification. Cells develop quickly and uncontrollably, which causes brain tumors and may cause death unless handled in the beginning stages. Therefore, a transfer learning framework for brain tumor classification is presented to simplify the task of healthcare professionals by automating tough medical processes. MRI image analysis was done on a publicly available dataset from Kaggle. The proposed method is implemented on VGG16, ResNet50, EfficientNetB0, and U-Net architectures. Training accuracy and test accuracy of all these four neural architectures compared and results that U-Net performs better in the classification of brain tumors compared to the other networks.
AR-Driven Smart Homes: Enhancing Automation and User Experience
Authors: Aayush Krishna  , Veerajeyan Brindha  , Aditya Mishra  , Karthik Uthaman
Published: February 2025

The study introduces a novel home automation system that leverages Augmented Reality (AR) technology to revolutionize user interaction and control of electrical appliances. Augmented Reality provides a dynamic platform for crafting personalized and interactive content, which aligns with the overarching goal of making home automation more intuitive and accessible to users. The primary objective is to develop a user-friendly application capable of generating AR buttons for controlling a variety of electrical appliances. These AR buttons are presented as 3D models on mobile devices accessible via standard web browsers. The application securely transmits data to a server, which then relays control commands to an ESP-32 microcontroller, effectively supplanting traditional switchboards. A key innovation in this system is the utilization of image-based targets to enable seamless interaction with virtual buttons. This approach allows users to effortlessly manage lighting, door locks, and air conditioning through intuitive virtual interfaces, thereby enhancing the overall efffciency and convenience of home automation. The focal point of this research lies in integrating AR technology into the smart home ecosystem to create a more intuitive and interactive user experience. By doing so, it contributes to the ongoing efforts aimed at simplifying and enhancing daily life through the convergence of digital technology and the physical environment. This study represents a signiffcant step forward in the evolution of home automation systems, offering users unprecedented control and interaction capabilities through the innovative application of AR technology.
Penggunaan Software Zahir POS 6 Sebagai Implementasi ICT Di Bidang Akuntansi
Authors: Murdhaningsih Murdhaningsih , Wulandari Indrianti , Putri Devi Aisyah
Published: February 2025

Kebutuhan akan teknologi dan informasi di masyarakat berkembang dengan pesat. Teknologi dan efisiensi waktu dalam kehidupan menjadi tujuan utama masyarakat untuk menghasilkan informasi yang lebih cepat, tepat dan akurat. Teknologi dan informasi yang terus berkembang, diikuti juga dengan peningkatan kualitas sumber daya manusia yang diharapkan mampu menciptakan dan mengembangkan sebuah sistem komputerisasi.
Tujuan dari penelitian ini adalah untuk menganalisis penggunaan software zahir dalam implementasinya terhadap proses akuntansi. Hasil penelitian ini menggunakan metode penelitian kualitatif dengan pengumpulan data yang bersumber dari data primer. Hasil penelitian menunjukkan bahwa, aplikasi Software zahir POS 6 memudahkan dalan proses penginputan data penjualan, membuat pendataan lebih akurat serta membuat lebih efisien dalam hal pembukuan.
Negotiating Subjectivity and Body: Access to an E-pistolary Corporeality
Authors: Xia Dong
Published: February 2025

Through a reading two novels based on email communication, The Metaphysical Touch (1998) by Sylvia Brownrigg and The Correspondence Artist (2011) by Barbara Browning, this paper discusses the changing culture of subjectivity and the body when writing and digital technologies converge in the literary space. This paper employs Katherine Hayles’s conceptualisation that the signification built upon presence and absence has been challenged by a cultural perception built upon information patterns and randomness to chart the luminal space arising from email writing of and between the two novels. With a deconstruction of the dominant notion of human, that privileges self-ownership, mastery, and presence, the location of the subject moves from the fixated paper to an accretive database, where the body is no longer a self-contained property, but rather becomes a co-emerging, performative body. Finally, the paper demonstrates the necessity for introducing new vocabularies such as access and database that are more flexible and less intertwined with the metaphysics of presence, and for inclusion of presence/absence dialectics into pattern/randomness interplay instead of its displacement.
Play As Subversion: Videogames in the Age of Transhumanism
Authors: Harilal Shalini
Published: February 2025

This paper discusses the contemporary relevance of video games within the larger context of an increasingly technology-oriented societies. The argument proposed is that an optimistic view of the future as imagined by transhumanism could lead to an anticipation of radical goals like prolonged lifespan and immortality which, at present, remain unattainable, thereby creating a disconnect between expectations and outcomes. This paper argues that video games act as platforms for subconscious attempts at subverting this disconnect by providing players with the opportunity to create and/or inhabit game avatars. The existence of players within virtual game worlds as avatars is compared to the act of creating horcruxes in the fictional world of J. K. Rowling’s Harry Potter series where horcrux is a contraption that helps overcome death. By comparing the notion of horcrux to the habitation of game avatars, this paper argues that a video game is a potential site for the manifestation of figurative precautionary measures against death. These measures are posited as subversive mechanisms because the rhetoric of technological advancement disregards the intensely personal nature of dying. The paper argues that figurative video game horcruxing is a subjective coping mechanism which is in a way subversive to the official transhuman narrative.
Misrepresentation, Identity, and Authorship in Percival Everett's Erasure
Authors: Vörös Gergely
Published: February 2025

The microcosm of Percival Everett’s Erasure—just as our own world—is interwoven with a set of normative expectations that not only circumscribe the self-identity of its main character, Thelonious Monk Ellison, but have a determining effect on him as an author as well. This paper explores a delicate link connecting racial misrepresentations, cultural industries, and power inequalities. It argues that the novel seeks to undermine the historically dominant assumptions of racial authenticity as well as locate to true racial authenticity in the plurality of African American experience. In doing so, it utilises Foucauldian notions of subjectivity, power, and discursive formations. Such concepts allow for the understanding of human subjectivity as the effect of larger semiotic systems. In this context, race is understood as a prescriptive rather than descriptive concept—a category that figures as a tool of social control. Consequently, Percival Everett’s Erasure enters into a dialogue with the dominant racial representations of the contemporary United States in the hope of deracialising the American imaginary.
Love as Nepenthe: Displacing Homer with Shelley in Joyce's Ulysses
Authors: Emerick-Brown Dylan
Published: February 2025

One of the least explored muses for James Joyce’s Ulysses was Percy Bysshe Shelley’s Prometheus Unbound which left its mark on Joyce’s protagonists, Leopold and Molly Bloom. Joyce quoted Aristotle in his notes in the spring of 1903, “It is harder to endure pain than to abstain from pleasure” and it is this exact sentiment that brings together the similarities between Shelley and Joyce, highlighting the Blooms’ yearning to banish grief from their minds regarding their deceased son, Rudy, and avoid the pain of loss, plaguing their marriage. One subtle Homeric seed from Prometheus Unbound—the word “nepenthe”—can be traced through Joyce’s early readings of Shelley’s play by his personal annotation in Shelley’s works within his Ulysses notebooks and the published novel. This word is the balm for a character and author who suffered through the death of a child—one alive for 11 days and the other never born. Joyce metaphorically uses nepenthe to represent chloroform, the substance Queen Victoria used to dull the pain of childbirth for her son of the same name as Bloom, Leopold. However, unlike Homer’s original use of nepenthe to simply banish grief from the mind, Joyce employs the version of nepenthe used by Shelley in which the drug is symbolic of love. This subtle contextual shift alters the theme of overcoming grief as not something to simply be eliminated, but rather something to be replaced by love. Understanding this can change the way in which readers approach the protagonist of Ulysses, the development of his struggle throughout the novel, and its ultimate conclusion
Unworlded After-Picture: The New State of Being in the Virtual Cosmos
Authors: Brunelli Mary Claire
Published: February 2025

In 1938, Heidegger christened his era “the age of the world picture,” evoking the human capacity to represent a meaningful existence through authentic social engagement and care for shared surroundings. There have been various “world pictures” throughout history, each a response to popular media produced by the latest technology. From papyrus to print, alphabetic writing has long supported literature as the dominant medium. Now, the development of digital, virtual, and network technology is dethroning this tradition and reshaping the world picture established through text. Brian Rotman notes that habituation to new technologies is restructuring the brain’s cognitive architecture, resulting in unpredicted consequences on thought, activity, and selfhood. The private, self-contained, alphabetic “I” is splintering into the porous, pluralistic, public agent that Rotman calls para-self. Accessible and available at all times, adept at navigating the invisible pathways of global cyberspace, simultaneously “present” at numerous “sites,” crisscrossed by networks of other selves and simulacra of itself through an ongoing stream of spontaneous information, this para-self does indeed present a picture of the world that corresponds to the technology used to build it, digitization. The question is, to what extent can this digital imaginary sustain the “world picture” heralded by Heidegger as a participatory and conscientious unity of Being-in-the-world?
Resistance as Embodied Experience: A Study of Mahasweta Devi's "Draupadi" and "Behind the Bodice
Authors: Sinha Anoushka
Published: February 2025

Experience and knowledge might seem interchangeable terms. However, when theoretically examined, they pose a conflicting dilemma in their respective nature and relation with each other. On one hand, knowledge is primarily derived from experience. The intrinsic characteristic of intimacy and immediacy of any experience categorizes it as highly subjective. Knowledge, on the other hand, is categorized as objective, pertaining to a certain universal appeal. Hereby arises a schism between the two concepts: experience and knowledge. This paper sets out to interrogate the complex relationship between the two concepts through a critical examination of Mahasweta Devi’s short fiction, “Draupadi” (1981) and “Behind the Bodice” (1996). The protagonists of these stories emerge as agents of resistance as the body becomes a crucial site of embodiment of experience. The complexity of experience and its role in the formation of the subject is explored through the course of this paper.
Image and Truth: Paradigms of Modern Translation Theory
Authors: Alhashmi Rawad
Published: February 2025

The field of translation theory witnessed two revolutionary shifts in the twentieth-century. These paradigm shifts are here attributed to the innovative theories of two key thinkers, the German philosopher and cultural critic Walter Benjamin and the American poet and critic Ezra Pound. Despite writing in the same century, and making significant contributions to the development of translation, there are differences in emphasis and approach, which present a scope to be delineated and assessed. This paper, then, seeks to underscore their conceptual accounts in the discipline of translation studies, primarily in terms of how their theories arguably resonate, and where they have diverged along their particular paths.
Ivermectin, a Molecular Swiss Army Knife: A Review of Mechanisms, Indications and Safety Concerns in Drug Repurposing
Authors: Halma Matthew , Vottero Paola
Published: February 2025

Ivermectin, originally developed for the treatment of parasitic diseases such as onchocerciasis (river blindness), has earned its title of "wonder drug" due to its broad-spectrum therapeutic activity. Ivermectin’s potential to address unmet global health challenges makes it an important focus for future medical research. This review explores ivermectin’s mechanisms of action and its expanding therapeutic applications, including in parasitic, bacterial and viral infections, and cancer among other disorders. It demonstrates a robust safety profile, and wide scale studies have not demonstrated reproductive harm in humans. This review highlights the ongoing research and emphasizes the need for careful consideration of both the benefits and risks of ivermectin. Further studies are required to support its repurposing for new indications.
Translational Issues: Should we care?
Authors: Halma Matt , Varon Joseph
Published: February 2025

To the Editor:

N1-methyl-pseudouridylated (m1Ψ) RNA enabled the mRNA Covid-19 vaccines to save lives during the pandemic, however, many questions exist on how the modified mRNA behaves in vivo. A recent study by Monroe and coworkers, shows slight, context dependent changes in translational fidelity.

The earliest study on translation of m1ΨRNA dates to 2015. One study on translational fidelity found no statistically significant difference between the protein products of m1ΨRNA and standard RNA (1). However, additional experiments published after the vaccination campaign show significant changes in translational output between normal RNA and m1ΨRNA (2,3).

The first result saw that m1ΨRNA increased rates of +1 ribosomal frameshifting, affecting approximately 8% of proteins produced (3). The most recent result found that m1ΨRNA translational fidelity is highly dependent on the sequence context (2), which explains why it was not observed in a previous study (1).

Taken together, these results suggest that we still do not know how chemical modifications impact translation. m1ΨRNA is rare, but not unprecedented in nature. It is found in archaea, first discovered in 1982, and later found in other extremophiles, at a specific position in their transfer RNA.

The recent discoveries by Monroe and associates of context-dependent fidelity underscores the need for greater basic science understanding of processes before widespread application. These potential issues with translational fidelity have fortunately manifested into safety problems with the mRNA vaccines, but this could depend on the specific antigen. Further testing should accompany any mRNA vaccine using this chemical modification.
Sacred Secularity as Spirituality and Holiness
Authors: Varghese Manimala Varghese Manimala
Published: February 2025

The main thrust of this paper is to look at spirituality from a
‘secular’ perspective. We want to stress the fact that spirituality is a
universal prerogative, and not the monopoly of an elite group. Holiness
consists of a search for justice and it is centered around Mother Earth,
rather than anything beyond. This new type of spirituality is, in the
words of Dr. Raimon Panikkar, Cosmotheandrism. Today spirituality has
to be very much concerned about the ecological problems, and only a true
‘Ecosophy’ can help to build up an authentic spirituality. Holiness cannot
be thought of bereft of social involvement, and in the name of spirituality
we cannot shirk our social responsibility. In the contemporary world
spirituality and holiness inevitably will consist of a protest against
nuclear arms race, sale of weapons and war; and also economic and
intellectual colonialism. Spirituality and holiness will also call for gender
justice. This new form spirituality can be built up only through ahiṁsa
(non-violence).
Hubungan Antara Disiplin Belajar dengan Hasil Belajarpada Mata Pelajaran Bahasa Indonesia Kelas IV Siswa Sekolah Dasardi Palembang
Authors: Sandi Sandi , Akhbar M. Taheri , Surmilasari Nora
Published: February 2025

The purpose of this study was to determine the Effect of Resistance Band and Pull Up Training on the Ability of 50 50-meter breaststroke Swimming in Prabumulih City Swimmers. This research method uses an experimental method with a two-group pretest-posttest research design. The sampling technique was taken randomly. Based on the results of this study, show that the t-test value of the resistance band group pretest and posttest is 4.608> 2.16 with a significance of 0.004> 0.05, meaning that there is a significant effect in resistance band training on the ability to swim 50 m breaststroke. The results of the t-test show that the t-test value of the pull-up group pretest and posttest is 7.050> 2.16 with a significance of 0.000> 0.05, meaning that there is a significant effect in pull-up training on the ability to swim 50 m breaststroke. There is a difference based on the average posttest resistance band training of 43.67 while pull-up training is 44.17.
Pengaruh Influencer Marketing Terhadap Niat Beli Produk Virtual Skin pada Game Mobile Legends Bang-Bang
Authors: Yuritanto Yuritanto , Sofian Hocky , Armansyah Armansyah , Saputra Tommy
Published: February 2025

Penelitian ini bertujuan mengkaji pengaruh Influencer Marketing terhadap niat beli produk virtual skin secara simultan pada mahasiswa STIE Tanjungpinang dengan pendekatan kuantitatif. Sampel penelitian melibatkan 51 mahasiswa yang dipilih menggunakan teknik purposive sampling. Data diperoleh melalui kuesioner dan studi pustaka, lalu dianalisis menggunakan uji kualitas data, asumsi klasik, regresi linear berganda, dan hipotesis dengan SPSS 22. Hasil menunjukkan nilai t hitung Influencer Marketing sebesar 9,891 (t tabel 2,008, sig. 0,000), sehingga H1 diterima. Pengaruh variabel ini terhadap niat beli adalah 66%, sisanya dipengaruhi faktor lain. Influencer Marketing efektif dalam membangun citra merek dan merangsang respons positif konsumen melalui platform online, memberikan kesempatan bagi influencer untuk memengaruhi sikap dan perilaku konsumen. Pemasaran melalui influencer berdampak signifikan pada niat beli produk Virtual Skin dalam game Mobile Legends Bang-Bang, dengan nilai uji statistik menunjukkan pengaruh yang positif dan signifikan.
PENDAYAGUNAAN KELEMBAGAAN LOKAL DALAM MENINGKATKAN KETAHANAN PANGAN MASYARAKAT PADA MASA PANDEMI COVID-19
Authors:   University of Indonesia, Sari Novita , Adi Isbandi Rukminto ,   University of Indonesia
Published: February 2025

The Covid-19 pandemic is a disease outbreak that has hit Indonesia since 2020. The impact of this epidemic changed the order and habits of society in general. This pandemic not only destroyed the health and economic structure, but also triggered a world food crisis, including Indonesia. Regions in Indonesia are experiencing various problems and crises, one of which is Kampar Regency. The fulfillment of food needs in Kampar Regency is mostly imported from West Sumatra via the West Sumatra-Riau national road. The dependence of Kampar Regency on West Sumatra can be seen when landslides occur, so there is a spike in food prices, especially staple foods. Now that uncertain conditions due to Covid-19 have limited the space for distributing food, crisis conditions like this require development that involves the community and local institutions directly by empowering all potential people. The local government of Kampar Regency carries out plans that produce policies to realize local development of food security through the use of community yards or land as an effort to optimize community independence in maintaining food security. This study will describe how the planning process for the utilization of local institutions in Kampar Regency through existing conditions, which are then analyzed, leads to policy interpretation. This research uses a qualitative approach with a descriptive type of research. Meanwhile, for data collection using an in-depth interview method. The results of this study describe the development of strategies and obstacles as well as efforts to utilize local institutions in the planning process, explaining the involvement of actors in the planning process as well as obstacles and ways to overcome certain obstacles.
Pemberdayaan Perempuan Melalui Lembaga Keuangan Mikro
Authors:   Universitas Indonesia, aljihad ali , wibowo arif ,   Universitas Indonesia
Published: February 2025

The existence of disparities between the human development index of women and men and the mandate of the RPJMN regarding gender equality needs to be considered. Empowerment of women through microfinance has long been implemented and is indeed the main target for microfinance institutions that run it. With so many studies on women's empowerment, there needs to be an analysis of how the forms of empowerment are carried out by microfinance institutions. This writing uses a literature review method which discusses five microfinance institutions from existing research, then analyzes how the forms of women's empowerment are carried out by these financial institutions and how the impact on women who receive them. This paper produces a finding that the empowerment carried out by microfinance is financial intermediation, social intermediation, and capacity building training. The model of microfinance institutions that provides a complete set is referred to as an integrative approach, the impact of the empowerment carried out by these microfinance institutions include opening up women's access to financial services, increasing income and running businesses, as well as increasing self and social capacity. With the services provided by these microfinance institutions, women become more empowered at least at the economic level, such as an increase in income that is in line with the ability to buy, however empowerment has not yet reached a higher socio-political level. This microfinance institution is a steppingstone for women to be empowered at a higher level.
Sleep need driven oscillation of glutamate synaptic phenotype
Authors: Vogt Kaspar E , Kulkarni Ashwinikumar , Pandey Richa , Dehnad Mantre , Konopka Genevieve , Greene Robert W
Published: February 2025

Sleep loss increases AMPA-synaptic strength and number in the neocortex. However, this is only part of the synaptic sleep loss response. We report an increased AMPA/NMDA EPSC ratio in frontal-cortical pyramidal neurons of layers 2–3. Silent synapses are absent, decreasing the plastic potential to convert silent NMDA to active AMPA synapses. These sleep loss changes are recovered by sleep. Sleep genes are enriched for synaptic shaping cellular components controlling glutamate synapse phenotype, overlap with autism risk genes, and are primarily observed in excitatory pyramidal neurons projecting intra-telencephalically. These genes are enriched with genes controlled by the transcription factor, MEF2c, and its repressor, HDAC4. Sleep genes can thus provide a framework within which motor learning and training occur mediated by the sleep-dependent oscillation of glutamate-synaptic phenotypes.
Broad-scale spatial distribution, microhabitat association and habitat partitioning of damselfishes (family Pomacentridae) on an Okinawan coral reef
Authors: Nanami Atsushi
Published: February 2025

Spatial distribution of coral reef fishes is related to diverse environmental variables. This study aimed to elucidate the (1) broad-scale spatial distribution, (2) microhabitat-scale substrate association, (3) degree of dependence on live corals and (4) habitat partitioning of 26 damselfish species on an Okinawan coral reef. Broad-scale analysis revealed that fish assemblages could be divided into three groups in relation to the degree of wave exposure, and the coverage of live corals as well as non-coralline substrates: (1) 11 species that were found in exposed reefs with greater coverage of rock; (2) nine species that that were found in inner reefs with greater coverage of live corals, dead corals and macroalgae; and (3) six species that were found in inner reefs with a greater coverage of sand. Microhabitat-scale analysis revealed that fish assemblages could be divided into six groups in relation to diverse microhabitat availability: (1) 12 species showed significant positive associations with rock; (2) two species showed significant positive associations with coral rubble; (3) two species showed significant positive associations with corymbose Acropora, Pocillopora and branching corals; (4) three species showed significant positive associations with branching Acropora; (5) three species showed significant positive associations with branching Acropora, branching Isopora and branching Porites; and (6) two species showed significant positive associations with staghorn Acropora and branching Millepora. The microhabitat-scale analysis also revealed that Pomacentrus amboinensis showed a significant positive association with branching Millepora, whereas Neopomacentrus anabatoides showed significant positive associations with branching Porites, foliose coral and dead branching Porites. Among the 26 species, nine species were categorized as obligate coral dwellers (>80% of the individuals were associated with live corals), and three species showed a greater degree of dependence on acroporid corals (>60% individuals were associated with acroporid coral). Niche overlap analysis revealed that 14 species showed relatively greater habitat partitioning with other species, whereas the remaining 12 species showed greater habitat overlaps among some species. These results suggest that broad-scale and microhabitat-scale habitat partitioning is one of the factors supporting coexistence in at least 14 species among the 26 species, and the effects of habitat diversity on the species coexistence of damselfishes should be incorporated to establish effective marine protected areas to preserve damselfish species diversity.
Ecology and structure of the biosphere
Authors: Jirkov Igor
Published: February 2025

The biosphere is formed by a few biomes (coenotic systems): 174 terrestrial biomes, ~ 300 on the seabed, in the pelagic zone of the ocean ~ 60. The boundaries between biomes are very sharp (fractions of a percent of the extent of the biomes themselves). Sharp gradients of environmental factors are not the cause of the emergence of boundaries, but can be their attractors. Abiotic factors on opposite sides of a biogeographic boundary may even be identical. Once established, boundaries can persist for tens of millions of years, despite ongoing climate changes.
Aquaculture in southern Russia: stagnation or development?
Authors: Matishov Gennady
Published: February 2025

In modern reality, the problems and prospects of aquaculture development in the south of Russia are becoming particularly relevant. It is shown that in the conditions of reduction of natural catches and disappearance of local native species in the southern seas of Russia and their basins (Sea of Azov, Black Sea, Caspian Sea), aquaculture remains the alternative to provide the population with affordable seafood and fish. At the same time, the main type of aquaculture in the south of Russia is associated with pond production of cyprinids. Endangered species of fish and invertebrates (sturgeon, walleye, pelengas, pike, shemaya, crayfish, shrimp) are just beginning to enter the range of interests of companies engaged in aquaculture. The prospects of aquaculture development in the south of Russia, which the authors associate with new biological objects and production methods, are outlined. It is noted that without a modern fishing fleet (for aquaculture needs), the development of technical means of aquaculture and the production of local combined feed, it will be difficult to solve a wide range of problems associated with Russia’s leadership in the field of world aquaculture and food security of the country.
The top of the cone. In memory of Academician B. L. Astaurov (1907–1977) E. B.
Authors: Astaurova Ekaterina
Published: February 2025

Boris Lvovich Astaurov is one of the most prominent personalities in Russian biology. He influenced to a large extent on the development of genetics and embryology. He contributed on the development of science as a scientist and as a Person. Astaurov performed fundamental studies of the mechanism of biological action of X-rays. He showed that the target of their destructive influence is the nuclear apparatus of the cell, and on this basis he created a theory of radiation damage to the body. Astaurov’s research on sex regulation is widely known in the whole world: he developed methods of thermal parthenogenesis and arbitrary production of male or female individuals from silkworms. Having developed for the first time in the world the finest experimental technique, Astaurov replaced the egg nucleus of one species of silkworm with the nucleus of another species and gave the final proof of the crucial role of the nucleus in the genetic control of the development of traits.
Healthcare Professionals' User Perceptions of Electronic Health Records (EHRS) in Brazilian Primary Health Care
Authors: Ferreira Amanda Pereira , Sousa Anésio Mendes de , Junior Geraldo Barroso Cavalcanti , Kramer Dany Geraldo
Published: February 2025

Objective: To analyze the perception of Primary Health Care (PHC) professionals about the process of implementation and use of the Electronic Citizen Record (ECR).
Methods: This is an exploratory and longitudinal survey study, with PHC professionals from the city of Parnamirim, Rio Grande do Norte, Brazil, as participants. An adapted questionnaire (Likert) was used for data collection. The data obtained were entered and tabulated in the SPSS 26.0 software and analyzed based on descriptive statistics and inferential analysis using Pearson's chi-square test (x²), assuming a significance of 5% (p≤0.05).
Results: Most interviewees were female (76.6%), aged between 31 and 50 years (61.7%). Of the interviewees, 67% agreed that the ECR is easy to use, 75% agreed that the ECR allows them to complete tasks faster, and 75% stated that the ECR ensures better work performance. There was a statistically significant difference in terms of improving work performance and ease of use of the system.
Conclusion: Therefore, it can be inferred that the use of the PEC was well accepted by professionals, bringing greater agility and efficiency to work in PHC. It is important to continue training these professionals with this system, favoring efficiency in serving users.
Water Quality Assessment of Hashidu Reservoir Along River Gongola, Gombe State Nigeria
Authors: Umar Abubakar M. , Danladi Simon , Isah Zainab , Kiman Suwaiba H. , Aisami Abubakar , Bako Nata’ala
Published: February 2025

Aims: This study aim to assess the water quality in relation to fisheries of Hashidu reservoir.
Study Design: Water samples for the physicochemical analysis were collected from Hashidu reservoir monthly over a period of six months cutting across both dry and rainy seasons.
Methodology: Water samples were collected from three locations using 250 ml sampling bottles and was taken to the laboratory for analysis. physicochemical parameters were analyzed using standard water sampling protocols. The water pH and temperature were determined using WTW pH and temperature electrodes. He turbidity meter was calibrated using potassium chloride solution. the turbidity was determined using turbidity meter by pressing the mode button until the arrow appeared as c0n in the displayer. Electrical conductivity was measured using the same Hanna measuring instrument (combo /EC model h198129). Dissolved oxygen was measured with Jenway model 1970 waterproof D.O meter at all the sites. Biochemical oxygen demand (bod) was determined as the difference in dissolved oxygen (do) before and after incubation of the water sample at 20 oc for 5 days.
Results: The mean values for physicochemical parameters recorded during dry and rainy seasons are pH (7.42, 6.77), electrical conductivity (353.50 µS/CM, 545.30 µS/CM), DISSOLVED oxygen (6.77 MG/L, 6.00 MG/L), turbidity (3.94 CM, 3.48 CM), temperature (32OC 29.3OC), BOD (3.69 MG/L, 6.00 MG/L) and COD (6.22 MG/L, 6.00 MG/L) respectively. While the mean values the major anions are nitrate (44.00 MG/L, 50 MG/L), phosphate (11.38 MG/L, 17.70 MG/L), sulphate (15.00 MG/L, 25.50 MG/L), chloride (37.23 MG/L, 240.69 MG/L), fluoride (0.028 MG/L, 0.059 MG/L).
Conclusion: Most of the parameters were within the limits set by who except pH, temperature and phosphate. there is need for continuous monitoring of water quality parameters for sustainable management of natural resources.