bluuebunny/crossref_metadata_2025 huggingface dataset:
Promoter methylation might shift the balance of Galectin-3 & 12 expression in de novo adult acute myeloid leukemia patients
Authors: Assem Magda , El-Araby Rady E. , Al-Karmalawy Ahmed A. , Nabil Reem , Kamal Mohamed A. M. , Belal Amany , Ghamry Heba I. , Abourehab Mohammed A. S. , Ghoneim Mohammed M. , Alshahrani Mohammad Y. , El Leithy Asmaa A.
Published: February 2023

Acute myeloid leukemia (AML) was reported as the most common type of leukemia among adults. Galectins constitute a family of galactose-binding proteins reported to play a critical role in many malignancies including AML. Galectin-3 and -12 are members of the mammalian galectin family. To understand the contribution of galectin-3 and -12 promoter methylation to their expression, we performed bisulfite methylation-specific (MSP)-PCR and bisulfite genomic sequencing (BGS) of primary leukemic cells in patients with de novo AML before receiving any therapy. Here, we show a significant loss of LGALS12 gene expression in association with promoter methylation. The lowest degree of expression was found in the methylated (M) group while the highest degree was in the unmethylated (U) group and the partially methylated (P) group expression lies in between. This was not the case with galectin-3 in our cohort unless the CpG sites analyzed were outside the frame of the studied fragment. We were also able to identify four CpG sites (CpG number 1, 5, 7& 8) in the promoter region of galectin-12; these sites must be unmethylated so that expression can be induced. As far as the authors know, these findings were not previously concluded in earlier studies.
Increased histone H3 acetylation inhibit the inflammatory response and activate the serum immunity of Pearl oyster Pinctada fucata martensii
Authors: Yang Jingmiao , Yang Shuai , Liao Yongshan , Deng Yuewen , Jiao Yu
Published: February 2023

To produce cultured pearls, a mantle graft with a nucleus is transplanted into a host pearl oyster, this process is called “transplantation”. The immune response of pearl oyster after transplantation is a major factor that leads to nucleus rejection and death. Butyrate is a histone deacetylase (HDAC) inhibitor which can inhibit the deacetylation process of histones and effectively reduce the inflammatory response. To clarify the function of histone acetylation in immune response after transplantation, butyrate (10 mmol/L) was used for the treatment of pearl oysters before transplantation. Results showed that the proportion of histone H3 acetylation of the hemocytes was significantly increased after butyrate treatment before transplantation (BH group) compared with the control group at 6–24 h. Transcriptome analysis showed that butyrate treatment activated the “lysosome”, inhibited cell migration and cell proliferation at 6 and 12 h, respectively, and activated the intracellular immune recognition response of pearl oyster at 24 h after transplantation. The apoptosis detection revealed no significant difference in the proportion of apoptotic cells between the control and BH group. Moreover, butyrate treatment increased the activity of some immune-related enzymes in the serum of pearl oyster after transplantation.
Machine learning-based prediction of candidate gene biomarkers correlated with immune infiltration in patients with idiopathic pulmonary fibrosis
Authors: Zhang Yufeng , Wang Cong , Xia Qingqing , Jiang Weilong , Zhang Huizhe , Amiri-Ardekani Ehsan , Hua Haibing , Cheng Yi
Published: February 2023

Objective

This study aimed to identify candidate gene biomarkers associated with immune infiltration in idiopathic pulmonary fibrosis (IPF) based on machine learning algorithms.

Methods

Microarray datasets of IPF were extracted from the Gene Expression Omnibus (GEO) database to screen for differentially expressed genes (DEGs). The DEGs were subjected to enrichment analysis, and two machine learning algorithms were used to identify candidate genes associated with IPF. These genes were verified in a validation cohort from the GEO database. Receiver operating characteristic (ROC) curves were plotted to assess the predictive value of the IPF-associated genes. The cell-type identification by estimating relative subsets of RNA transcripts (CIBERSORT) algorithm was used to evaluate the proportion of immune cells in IPF and normal tissues. Additionally, the correlation between the expression of IPF-associated genes and the infiltration levels of immune cells was examined.

Results

A total of 302 upregulated and 192 downregulated genes were identified. Functional annotation, pathway enrichment, Disease Ontology and gene set enrichment analyses revealed that the DEGs were related to the extracellular matrix and immune responses. COL3A1, CDH3, CEBPD, and GPIHBP1 were identified as candidate biomarkers using machine learning algorithms, and their predictive value was verified in a validation cohort. Additionally, ROC analysis revealed that the four genes had high predictive accuracy. The infiltration levels of plasma cells, M0 macrophages and resting dendritic cells were higher and those of resting natural killer (NK) cells, M1 macrophages and eosinophils were lower in the lung tissues of patients with IPF than in those of healthy individuals. The expression of the abovementioned genes was correlated with the infiltration levels of plasma cells, M0 macrophages and eosinophils.

Conclusion

COL3A1, CDH3, CEBPD, and GPIHBP1 are candidate biomarkers of IPF. Plasma cells, M0 macrophages and eosinophils may be involved in the development of IPF and may serve as immunotherapeutic targets in IPF.
Riemannian geometry-based metrics to measure and reinforce user performance changes during brain-computer interface user training
Authors: Ivanov Nicolas , Chau Tom
Published: February 2023

Despite growing interest and research into brain-computer interfaces (BCI), their usage remains limited outside of research laboratories. One reason for this is BCI inefficiency, the phenomenon where a significant number of potential users are unable to produce machine-discernible brain signal patterns to control the devices. To reduce the prevalence of BCI inefficiency, some have advocated for novel user-training protocols that enable users to more effectively modulate their neural activity. Important considerations for the design of these protocols are the assessment measures that are used for evaluating user performance and for providing feedback that guides skill acquisition. Herein, we present three trial-wise adaptations (running, sliding window and weighted average) of Riemannian geometry-based user-performance metrics (classDistinct reflecting the degree of class separability and classStability reflecting the level of within-class consistency) to enable feedback to the user following each individual trial. We evaluated these metrics, along with conventional classifier feedback, using simulated and previously recorded sensorimotor rhythm-BCI data to assess their correlation with and discrimination of broader trends in user performance. Analysis revealed that the sliding window and weighted average variants of our proposed trial-wise Riemannian geometry-based metrics more accurately reflected performance changes during BCI sessions compared to conventional classifier output. The results indicate the metrics are a viable method for evaluating and tracking user performance changes during BCI-user training and, therefore, further investigation into how these metrics may be presented to users during training is warranted.
Novel compound heterozygous mutations of LAMA2-limb–girdle muscular dystrophy: A case report and literature review
Authors: Wang Duo-Zi , Li Bing-Hu , Ma Qiong , Yu Zhou , Chen Kai , He Ying , Tan Song
Published: February 2023

The laminin α2 (LAMA2) gene pathogenic variants can lead to limb–girdle muscular dystrophy (known as LGMDR23), which is rarely reported and characterized by proximal weakness in the limbs. We present the case of a 52-year-old woman who gradually developed weakness in both lower extremities since the age of 32 years. Magnetic resonance imaging (MRI) brain showed symmetrical sphenoid wings-like white matter demyelination in bilateral lateral ventricles. Electromyography showed quadriceps muscle damage on the bilateral lower extremity. Next-generation sequencing (NGS) found two loci variations in the LAMA2 gene, i.e., c.2749 + 2dup and c.8689C>T. This case highlights the importance of considering LGMDR23 in patients presenting with weakness and white matter demyelination on MRI brain and further expands the gene variants spectrum of LGMDR23.
Uptake of Ni(II), Eu(III) and Pu(III/IV) by Hardened Cement Paste in the Presence of Proxy Ligands for the Degradation of Polyacrylonitrile
Authors: Szabo P. G. , Tasi A. G. , Gaona X. , Maier A. C. , Hedström S. , Altmaier M. , Geckeis H.
Published: February 2023

The uptake of 63Ni(II), 152Eu(III) and 242Pu(III/IV) by hardened cement paste (HCP, CEM I) in the degradation stage II (pH ≈ 12.5 [Ca] ≈ 0.02 M) was investigated in the absence and presence of α-hydroxyisobutyric, 3-hydroxybutyric and glutaric acids. These organic ligands were previously identified as proxies for the degradation products of UP2W (a polyacrylonitrile-based material used as filter aid in nuclear power plants) under repository conditions. Sorption experiments were conducted with various ligand concentrations (10−4 M ≤ [L]tot ≤ 0.1 M) and solid-to-liquid ratios (0.5 g⋅dm–3 ≤ S:L ≤ 20 g⋅dm–3). Redox conditions in the Pu systems were buffered with either hydroquinone (HQ, pe + pH ≈ 10) or Sn(II) (pe + pH ≈ 2). Strong sorption is observed for 152Eu(III) and 242Pu(III/IV) in the absence of proxy ligands, with distribution coefficients (log Rd ≈ 2.2–4, with Rd in m3⋅kg–1) in line with data reported in the literature. No differences are observed for sorption experiments with Pu in HQ and Sn(II) systems. Lower Rd values are determined for 63Ni(II) (log Rd,Ni63 ≈ 0-1), consistently with previous studies. In combination with log Rd,Ni determined on the basis of the concentration of stable Ni(II) in pristine HCP and in cement porewater, values of the partition coefficient (α) close to 1 are determined. This suggests that the uptake of 63Ni is possibly driven by isotopic exchange with the complete species inventory of stable Ni present in pristine HCP, including Ni in solid phases and associated with surfaces, e.g., of C-S-H phases. The presence of proxy ligands has a negligible effect on the uptake of 152Eu(III) up to [L]tot = 0.1 M. A slight decrease in the distribution ratios for 63Ni(II) and 242Pu(III/IV) is observed at [L]tot > 10−2 M, although the effect is less evident in the case of plutonium due to the dispersion of the data and the increase of the detection limits with increasing ligand concentrations. Compared to strongly complexing ligands like isosaccharinic acid or gluconate, the investigated proxy ligands show a minor capacity for radionuclide mobilization in cementitious systems, even at high concentrations.
Processed meat, red meat, white meat, and digestive tract cancers: A two-sample Mendelian randomization study
Authors: Yun Zhangjun , Nan Mengdie , Li Xiao , Liu Zhu , Xu Jing , Du Xiaofeng , Dong Qing , Hou Li
Published: February 2023

Background

Previous observational studies suggested inconsistent insights on the associations between meat intake and the risk of digestive tract cancers (DCTs). The causal effect of meat intake on DCTs is unclear.

Methods

Two-sample Mendelian randomization (MR) was performed based on genome-wide association studies (GWAS) summary data from UK Biobank and FinnGen to evaluate the causal effect of meat intake [processed meat, red meat (pork, beef, and lamb), and white meat (poultry)] on DCTs (esophageal, stomach, liver, biliary tract, pancreatic, and colorectal cancers). The causal effects were estimated using a primary analysis that employed inverse-variance weighting (IVW) and complementary analysis that utilized MR-Egger weighted by the median. A sensitivity analysis was conducted using the Cochran Q statistic, a funnel plot, the MR-Egger intercept, and a leave-one-out approach. MR-PRESSO and Radial MR were performed to identify and remove outliers. To demonstrate direct causal effects, multivariable MR (MVMR) was applied. In addition, risk factors were introduced to explore potential mediators of the relationship between exposure and outcome.

Results

The results of the univariable MR analysis indicated that genetically proxied processed meat intake was associated with an increased risk of colorectal cancer [IVW: odds ratio (OR) = 2.12, 95% confidence interval (CI) 1.07–4.19; P = 0.031]. The causal effect is consistent in MVMR (OR = 3.85, 95% CI 1.14–13.04; P = 0.030) after controlling for the influence of other types of exposure. The body mass index and total cholesterol did not mediate the causal effects described above. There was no evidence to support the causal effects of processed meat intake on other cancers, except for colorectal cancer. Similarly, there is no causal association between red meat, white meat intake, and DCTs.

Conclusions

Our study reported that processed meat intake increases the risk of colorectal cancer rather than other DCTs. No causal relationship was observed between red and white meat intake and DCTs.
[18F]FDG PET/CT versus [18F]FDG PET/MRI for the diagnosis of colorectal liver metastasis: A systematic review and meta-analysis
Authors: Miao Zhi , Zhao Xiaomeng , Li Xuanwen
Published: February 2023

Purpose

The purpose of our meta-analysis and systematic review was to compare the diagnostic performance of [18F]FDG PET/CT and [18F]FDG PET/MRI in colorectal liver metastasis.

Methods

We searched PubMed, Embase, and Web of Science for eligible articles until November 2022. Studies focusing on the diagnostic value of [18F]FDG PET/CT or PET/MRI for colorectal liver metastasis were included. Using a bivariate random-effect model, the pooled sensitivity and specificity for [18F]FDG PET/CT and [18F]FDG PET/MRI were reported as estimates with 95% confidence intervals (CIs). Heterogeneity among pooled studies was assessed using the I2 statistic. The Quality Assessment of Diagnostic Performance Studies (QUADAS-2) method was used to evaluate the quality of the studies that were included.

Results

There were a total of 2743 publications identified in the initial search, finally, a total of 21 studies comprising 1036 patients were included. The pooled sensitivity, specificity, and AUC of [18F]FDG PET/CT in were 0.86 (95% CI: 0.76-0.92), 0.89 (95% CI: 0.83-0.94), and 0.92(95% CI: 0.90-0.94). [18F]FDG PET/MRI were 0.84 (95% CI: 0.77-0.89), 1.00 (95% CI: 0.32–1.00), and 0.89(95% CI: 0.86-0.92), respectively.

Conclusion

[18F]FDG PET/CT shows similar performance compared to [18F]FDG PET/MRI in detecting colorectal liver metastasis. However, pathological results were not obtained for all patients in the included studies and PET/MRI results were derived from studies with small sample sizes. There is a need for additional, larger prospective studies on this issue.

Systematic review registration

https://www.crd.york.ac.uk/prospero/, identifier (CRD42023390949).
A biopsychosocial approach assessing pain indicators among Black men
Authors: Baker Tamara A. , Morales Knashawn H. , Brooks Amber K. , Clark Jaylyn F. , Wakita Anna , Whitt-Glover Melicia C. , Yu Yelia Z. , Murray Marcus , Hooker Steven P.
Published: February 2023

Introduction

The lack of empirical evidence documenting the pain experience of Black men may be the result of social messaging that men are to project strength and avoid any expression of emotion or vulnerability. This avoidant behavior however, often comes too late when illnesses/symptoms are more aggressive and/or diagnosed at a later stage. This highlights two key issues - the willingness to acknowledge pain and wanting to seek medical attention when experiencing pain.

Methods

To better understand the pain experience in diverse raced and gendered groups, this secondary data analysis aimed to determine the influence identified physical, psychosocial, and behavioral health indicators have in reporting pain among Black men. Data were taken from a baseline sample of 321 Black men, >40 years old, who participated in the randomized, controlled Active & Healthy Brotherhood (AHB) project. Statistical models were calculated to determine which indicators (somatization, depression, anxiety, demographics, medical illnesses) were associated with pain reports.

Results

Results showed that 22% of the men reported pain for more than 30 days, with more than half of the sample being married (54%), employed (53%), and earning an income above the federal poverty level (76%). Multivariate analyses showed that those reporting pain were more likely to be unemployed, earn less income, and reported more medical conditions and somatization tendencies (OR=3.28, 95% CI (1.33, 8.06) compared to those who did not report pain.

Discussion

Findings from this study indicate that efforts are needed to identify the unique pain experiences of Black men, while recognizing its impact on their identities as a man, a person of color, and someone living with pain. This allows for more comprehensive assessments, treatment plans, and prevention approaches that may have beneficial impacts throughout the life course.
Olfactory training reduces pain sensitivity in children and adolescents with primary headaches
Authors: Gossrau Gudrun , Zaranek Laura , Klimova Anna , Sabatowski Rainer , Koch Thea , Richter Matthias , Haehner Antje
Published: February 2023

Objective

Headache prevalence among children and adolescents has increased over the last few years. Evidence-based treatment options for pediatric headaches remain limited. Research suggests a positive influence of odors on pain and mood. We investigated the effect of repeated exposure to odors on pain perception, headache-related disability, and olfactory function in children and adolescents with primary headaches.

Methods

Eighty patients with migraine or tension-type headache (mean 13.1 ± 3.29 years) participated, of whom 40 underwent daily olfactory training with individually selected pleasant odors for 3 months and 40 received state-of-the-art outpatient therapy as a control group. At baseline and after a 3-month follow-up, olfactory function [odor threshold; odor discrimination; odor identification; comprehensive Threshold, Discrimination, Identification (TDI) score], mechanical detection and pain threshold (quantitative sensory testing), electrical pain threshold, patient-reported outcomes on headache-related disability [Pediatric Migraine Disability Assessment (PedMIDAS)], pain disability [Pediatric Pain Disability Index (P-PDI)], and headache frequency were assessed.

Results

Training with odors significantly increased the electrical pain threshold compared to the control group (U = 470.000; z = −3.177; p = 0.001). Additionally, olfactory training significantly increased the olfactory function (TDI score [t(39) = −2.851; p = 0.007], in particular, olfactory threshold, compared to controls (U = 530.500; z = −2.647; p = 0.008). Headache frequency, PedMIDAS, and P-PDI decreased significantly in both groups without a group difference.

Conclusions

Exposure to odors has a positive effect on olfactory function and pain threshold in children and adolescents with primary headaches. Increased electrical pain thresholds might reduce sensitization for pain in patients with frequent headaches. The additional favorable effect on headache disability without relevant side effects underlines the potential of olfactory training as valuable nonpharmacological therapy in pediatric headaches.
The incidence and clinical characteristics of fragile X syndrome in China
Authors: Mei Lianni , Hu Chunchun , Li Dongyun , Wang Ya , Li Huiping , Zhang Kaifeng , Zhou Bingrui , Zhu Ruoping , Hagerman Randi J. , Xu Xiu , Xu Qiong
Published: February 2023

Introduction

Fragile X syndrome (FXS) is a X-linked neurodevelopmental disorder (NDD). This study aims to investigate the incidence of FXS in Chinese children and analyze the comprehensive clinical characteristics of these FXS children.

Methods

Children diagnosed with idiopathic NDD were recruited between 2016 and 2021 from the department of Child Health Care, Children's Hospital of Fudan University. We combined tetraplet-primed PCR-capillary electrophoresis and whole exome sequencing (WES)/panel or array-based comparative genomic hybridization (array-CGH) to identify the size of the CGG repeats and the mutations or copy number variations (CNVs) in the genome and in FMR1. The clinical features of FXS children were analyzed according to pediatricians' recording, parental questionnaires, the results of examinations and follow-up.

Results

The incidence of FXS in Chinese children with idiopathic NDD was 2.4% (42/1753) and in those with FXS, 2.38% had a deletion (1/42). Here, we present the clinical characteristics of 36 children with FXS. Overweight was observed in two boys. The average intelligence quotient (IQ)/development quotient (DQ) of all FXS patients was 48. The average ages of meaningful words and walking alone were 2 years and 10 months and 1 year and 7 months, respectively. The most frequent repetitive behavior was stimulated by hyperarousal to sensory stimulation. On social aspects, social withdrawal, social anxiety, and shyness accounted for 75%, 58%, and 56% of the total number of children, respectively. Approximately 60% of FXS children in this cohort were emotionally labile and prone to temper tantrums. Self-injury and aggression toward others could also be observed, at 19% and 28%, respectively. The most frequent behavioral problem was attention-deficit hyperactivity disorder (ADHD) seen in 64% and the most common facial features were a narrow and elongated face and large or prominent ears in 92% of patients.

Discussion

Screening of FMR1 full mutation provides the possibility for patients' further medical supports and the clinical features of FXS children obtained in this study will increase the understanding and diagnosis of FXS.
A case report of necrotizing enterocolitis in a moderately preterm neonate with LCHADD—A call to focus on the basics while utilizing advanced new therapies
Authors: Metzler Marina , Burns William , Mitchell Carly , Napolitano Stephanie , Chaudhari Bimal P.
Published: February 2023

Long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency (LCHADD) is an autosomal recessive condition of impaired beta-oxidation. Traditionally, treatment included restriction of dietary long-chain fatty acids via a low-fat diet and supplementation of medium chain triglycerides. In 2020, triheptanoin received FDA approval as an alternative source of medium chain fatty acids for individuals with long-chain fatty acid oxidation disorders (LC-FAOD). We present a case of a moderately preterm neonate born at 33 2/7 weeks gestational age with LCHADD who received triheptanoin and developed necrotizing enterocolitis (NEC). Prematurity is known as a major risk factor for NEC, with risk increasing with decreasing gestational age. To our knowledge, NEC has not previously been reported in patients with LCHADD or with triheptanoin use. While metabolic formula is part of the standard of care for LC-FAOD in early life, preterm neonates may benefit from more aggressive attempts to use skimmed human milk to minimize exposure to formula during the risk period for NEC during feed advancement. This risk period may be longer in neonates with LC-FAOD compared to otherwise healthy premature neonates.
Hydrogel scaffolds in bone regeneration: Their promising roles in angiogenesis
Authors: Liu Jun , Yang Lili , Liu Kexin , Gao Feng
Published: February 2023

Bone tissue engineering (BTE) has become a hopeful potential treatment strategy for large bone defects, including bone tumors, trauma, and extensive fractures, where the self-healing property of bone cannot repair the defect. Bone tissue engineering is composed of three main elements: progenitor/stem cells, scaffold, and growth factors/biochemical cues. Among the various biomaterial scaffolds, hydrogels are broadly used in bone tissue engineering owing to their biocompatibility, controllable mechanical characteristics, osteoconductive, and osteoinductive properties. During bone tissue engineering, angiogenesis plays a central role in the failure or success of bone reconstruction via discarding wastes and providing oxygen, minerals, nutrients, and growth factors to the injured microenvironment. This review presents an overview of bone tissue engineering and its requirements, hydrogel structure and characterization, the applications of hydrogels in bone regeneration, and the promising roles of hydrogels in bone angiogenesis during bone tissue engineering.
Calibration to maximize temporal radiometric repeatability of airborne hyperspectral imaging data
Authors: Nansen Christian , Lee Hyoseok , Mantri Anil
Published: February 2023

Many studies provide insight into calibration of airborne remote sensing data but very few specifically address the issue of temporal radiometric repeatability. In this study, we acquired airborne hyperspectral optical sensing data from experimental objects (white Teflon and colored panels) during 52 flight missions on three separate days. Data sets were subjected to four radiometric calibration methods: no radiometric calibration (radiance data), empirical line method calibration based on white calibration boards (ELM calibration), and two atmospheric radiative transfer model calibrations: 1) radiometric calibration with irradiance data acquired with a drone-mounted down-welling sensor (ARTM), and 2) modeled sun parameters and weather variables in combination with irradiance data from drone-mounted down-welling sensor (ARTM+). Spectral bands from 900-970 nm were found to be associated with disproportionally lower temporal radiometric repeatability than spectral bands from 416-900 nm. ELM calibration was found to be highly sensitive to time of flight missions (which is directly linked to sun parameters and weather conditions). Both ARTM calibrations outperformed ELM calibration, especially ARTM2+. Importantly, ARTM+ calibration markedly attenuated loss of radiometric repeatability in spectral bands beyond 900 nm and therefore improved possible contributions of these spectral bands to classification functions. We conclude that a minimum of 5% radiometric error (radiometric repeatability<95%), and probably considerably more error, should be expected when airborne remote sensing data are acquired at multiple time points across days. Consequently, objects being classified should be in classes that are at least 5% different in terms of average optical traits for classification functions to perform with high degree of accuracy and consistency. This study provides strong support for the claim that airborne remote sensing studies should include repeated data acquisitions from same objects at multiple time points. Such temporal replication is essential for classification functions to capture variation and stochastic noise caused by imaging equipment, and abiotic and environmental variables.
Internet and depression in adolescents: Evidence from China
Authors: Ma Yuna , Gu Jiafeng
Published: February 2023

Despite growing attention to Internet activity as a social determinant of depression in adolescents, few studies have focused on its diverse effects on depressive symptoms. Using data from the 2020 China Family Panel Study, this study employed logistic regression analysis to examine how Internet activity affects depressive symptoms in adolescents in China. The results indicated that adolescents with longer online duration using mobile phones tended to have higher levels of depression. Adolescents who engaged in online activities related to games, shopping, and entertainment had more severe depressive symptoms, but their time spent on online learning was not significantly associated with their level of depression. These findings suggest a dynamic link between Internet activity and adolescent depression and offer policy implications for addressing depressive symptoms in adolescents. Specifically, Internet and youth development policies and public health programs during the COVID-19 pandemic should be designed based on a comprehensive account of all aspects of Internet activity.
Effects of weight divisions in time-motion of female high-level Brazilian Jiu-jitsu combat behaviors
Authors: Santos Marco Antonio Ferreira dos , Soto Dany Alexis Sobarzo , de Brito Michele Andrade , Brito Ciro José , Aedo-Muñoz Esteban , Slimani Maamer , Bragazzi Nicola L. , Znazen Hela , Miarka Bianca
Published: February 2023

Coaches and psychologists can use time-motion analysis to elaborate specific interventions for female BJJ athletes, increasing specific training context and reducing unnecessary psychological and physical demands and injuries. Therefore, the present study aimed to analyze high-level BJJ female athletes in the 2020 Pan-American Games by comparing the weight categories on the time-motion analysis. The time-motion analysis (i.e., approach, gripping, attack, defensive actions, transition, mounting, guard, side control, and submissions) of 422 high-level female BJJ combats was divided and compared by weight category as follows: Rooster (n = 8), Light Feather (n = 18), Feather (n = 122), Light (n = 84), Middle (n = 74), Medium Heavy (n = 44), Heavy (n = 36), Super Heavy (n = 36), using p ≤ 0.05. The main results indicated that the Super heavyweight category [3.1 (5.8;119.9) s] had a shorter gripping time than other weight categories, p ≤ 0.05. In contrast, roosters [7.2 (3.5;64.6) s] had longer gripping, transition [14.0 (4.8;29.6) s], and attack time [76.2 (27.7, 93.2)] than the light feather, middlers, and heavier weight categories, p ≤ 0.05. These findings should be considered for the psychological interventions and training prescription.
Exploring the mechanism of consumer purchase intention in a traditional culture based on the theory of planned behavior
Authors: Zong Zupan , Liu Xinyu , Gao Huijing
Published: February 2023

There has been a growing interest among scholars and practitioners in cultural empowerment due to the importance of this subject. In this study, we aim to explore the connection between traditional cultural symbols and cultural identity, further estimating how two variables stimulate consumers’ emotional value to generate consumers’ purchase intention. Based on existing traditional cultural literature and the theory of planned behavior (TPB), we first proposed a research framework and then empirically tested the relationship among traditional culture symbols, cultural identity, emotional value, and consumers’ purchase intention. The survey data was tested using structural equation modeling (SEM) and the following conclusions were drawn. First, the cognition of traditional cultural symbols and cultural identity has a direct and significant impact on the emotional value thereby, eliciting consumers’ purchase intention. Second, traditional cultural symbols are directly and indirectly (i.e., through emotional value or cultural identity) positively associated with consumers’ purchase intention, also cultural identity is directly and indirectly (i.e., through emotional value) associated with consumer purchase intention. Finally, emotional values mediate the indirect effect of traditional culture and cultural identity on purchase intention, and cultural identity plays a moderating role between traditional cultural symbols and consumers’ purchase intention. Our findings help to expand the existing literature on consumer purchase intentions by rationally using traditional cultural symbols in the product design and suggesting relevant marketing strategies. The research results can provide valuable inspiration for promoting the sustainable development of the national tidal market and repeating consumers’ purchasing intentions.
The impact of enterprise resilience and HRM practices on performance: Findings from fsQCA
Authors: Liu Bo , Li Yan , Tang LinHua , Zhao Yipeng , Chang Haodong
Published: February 2023

Background

Both enterprise resilience and HRM practices can have a positive impact on enterprise performance. The impact of enterprise resilience or human resource management (HRM) practices on enterprise performance independently has been studied widely. But few studies have combined the above two aspects to discuss their impact on enterprise performance.

Objective

In order to provide positive conclusions for improving enterprise performance, the theoretical model is established to expound the relationship between enterprise resilience, HRM practices including their internal influencing factors and enterprise performance. According to this model, a series of hypotheses about the influence of the combination from these internal factors on enterprise performance are presented.

Method

Based on the statistical data of the questionnaire survey with managers and general employees at different levels in enterprises as respondents, the correctness of these hypotheses is proved by the fuzzy set qualitative comparative analysis (fsQCA) method.

Results and discussion

The impact of the combination of enterprise resilience for high enterprise performance is shown in Table 3. The positive impact on the configuration of HRM practices for enterprise performance is shown in Table 4. The influences of the various combinations of internal factors about enterprise resilience and HRM practices on enterprise performance are shown in Table 5. From Table 4, it is discovered that performance appraisal and training have a significant positive effect on high enterprise performance. From Table 5, it is found that information sharing capabilities play a critical role, and enterprise resilience capabilities have a relatively positive impact on enterprise performance. Therefore, managers need to seek the development of enterprise resilience and HRM practices simultaneously and choose the most suitable combination configuration according to the actual situation of the enterprise itself. Moreover, a meeting system should be set up to ensure the transmission of internal information efficiently and accurately.
Homocysteine level at the acute stage of ischemic stroke as a biomarker of poststroke depression: A systematic review and meta-analysis
Authors: Liang Yanling , Shi Xiangqun , Chen Lue , Li Yongxin , Zhong Jianping
Published: February 2023

Background

Studies on the association of homocysteine level with poststroke depression (PSD) have yielded conflicting results. This systematic review and meta-analysis aimed to evaluate the elevated homocysteine level at the acute stage of ischemic stroke in predicting PSD.

Methods

Two authors systematically searched articles indexed in PubMed and Embase databases up to 31 January 2022. Studies evaluating the association of homocysteine level with the development of PSD in patients with acute ischemic stroke were selected.

Results

A total of 10 studies involving 2,907 patients were identified. The pooled adjusted odds ratio (OR) of PSD was 3.72 [95% confidence intervals (CI) 2.03–6.81] for the top vs. bottom homocysteine level. The value of elevated homocysteine level in predicting PSD was stronger in ≥6-month follow-up (OR 4.81; 95% CI 3.12–7.43) than those in ≤ 3-month follow-up subgroup (OR 3.20; 95% CI 1.29–7.91). Moreover, a per unit increase in homocysteine level conferred a 7% higher risk of PSD.

Conclusion

Elevated homocysteine level in the acute stage of ischemic stroke may be an independent predictor of PSD.
Temporal trend and subgroup disparities in the prevalence and treatment of those who screen positive for depression in China: A population-based study
Authors: Chen Shanquan , Wang Yuqi
Published: February 2023

Background

In China, improving mental health has been far behind its accomplishments for other diseases. With depression as one of the most prevalent mental disorders, the aim of this study was to evaluate temporal trends in the prevalence and treatment of those who screen positive for depression in China, by age, gender, and province.

Methods

We used data from three nationally representative sample surveys: the China Health and Retirement Longitudinal Study (CHARLS), the China Family Panel Studies (CFPS), and the Chinese Longitudinal Healthy Longevity Survey (CLHLS). Depression was judged by the Centre for Epidemiologic Studies Depression Scale. Access to treatment was judged by two items: if respondents received any treatment like anti-depressants, or if respondents received counselling from a mental health professional. Survey-specific weighted regressions were fitted to estimate the temporal trend and subgroup disparities, and then pooled by meta-analysis.

Results

In total 168,887 respondents were investigated. The overall prevalence of China populations who screen positive for depression was 25.7% (95% CI 25.2–26.2) during 2016–2018, decreased from 32.2% (95% CI 31.6–32.8) during 2011–2012. The gender gap increased with age and had no significant improvement from 2011–2012 to 2016–2018. The prevalence of depression in developed areas is more likely to show a lower value and decreasing trend, while the prevalence in underdeveloped areas is more likely to show a higher value and increasing trend, from 2011–2012 to 2016–2018. The overall proportion of those who received any needed treatment or counselling from a mental health professional slightly increased from 2011 (0.5%, 95% CI 0.4–0.7) to 2018 (0.9%, 95% CI 0.7–1.2), and mainly occurred for older adults aged 75 and above.

Conclusion

The prevalence of those who screen positive for depression decreased by about 6.5% from 2011–2012 to 2016–2018 in China, but only tiny improvements were made in accessibility to mental health care. Corresponding disparities were identified in age, gender, and province.
The network approach: A path to decolonize mental health care
Authors: Alemu Rediet Emebet Getnet , Osborn Tom L. , Wasanga Christine M.
Published: February 2023

The violent colonial history of psychiatry in Africa prevents individuals from help-seeking. Because of this history, mental health care is now stigmatized, and clinical research, practice, and policy fail to capture the salient features of distress across African communities. If we are to transform mental health care for all, we must adopt decolonizing frameworks to ensure mental health research, practice, and policy are enacted in a manner that is ethical, democratic, critical, and serves the needs of local communities. Here, we present that the network approach to psychopathology as an invaluable tool in achieving this purpose. The network approach recognizes mental health disorders not as discrete entities, but rather as dynamic networks that are made of psychiatric symptoms (called nodes) and the relationships between these symptoms (called edges). This approach can pave a path to decolonizing mental health care by alleviating stigma, allowing context-based understanding of mental health and mental health problems, opening new avenues for (low-cost) mental health care and empowering local researchers to pioneer context-based knowledge production and treatment.
COVID-19 vaccination status in Germany: Factors and reasons for not being vaccinated (yet)
Authors: Sterl Sebastian , Stelzmann Daniela , Luettschwager Nils , Gerhold Lars
Published: February 2023

Introduction

The COVID-19 pandemic has demonstrated that effective vaccines constitute a central element of successful pandemic control. Although everyone in Germany has had the opportunity to receive a COVID-19 vaccine, some people remain hesitant or refuse to get vaccinated. To address this phenomenon as well as to examine the unvaccinated population more closely, the present study investigates (RQ1) factors explaining the COVID-19 vaccination status (RQ2) trust in different types of COVID-19 vaccines, and (RQ3) people's specific reasons for not getting vaccinated against COVID-19.

Methods

We base our findings on a representative survey that we conducted in Germany in December 2021 with 1,310 respondents.

Results

In response to the first research question, a logistic regression shows that trust in specific institutions (e.g., medical experts and authorities) is positively related to vaccination status, whereas trust in companies and COVID-19-related social and alternative media consumption decreases the likelihood of being vaccinated. Furthermore (RQ2), while vaccinated people trust mRNA-based vaccines (e.g., BioNTech), most unvaccinated people put greater trust in recently developed protein-based vaccines (e.g., Novavax), albeit on a low level. Finally, our study reveals (RQ3) that the most important reason why people choose not to get vaccinated is that they wish to make their own decisions about their bodies.

Conclusion

Based on our results, we suggest that a successful vaccination campaign should address COVID-19 risk groups and lower income populations, increase trust in different public institutions and newly developed vaccines in advance, establish a multisectoral approach, and debunk fake news and misinformation. Furthermore, since unvaccinated respondents state that the desire to make their own choices about their body is the main reason why they have not gotten vaccinated against COVID-19, an effective vaccination campaign should emphasize the need for general practitioners who have a closer relationship with their patients who, in turn, trust their doctors.
PCR combined with serologic testing improves the yield and efficiency of SARS-CoV-2 infection hunting: A study in 40,689 consecutive overseas arrivals
Authors: Fang Li-Li , Zhu Jian-Hui , Cai Min-Jing , Zhang Jing-Wen , Jiang Long-Can , Dai Zhang , Lin Yu , Liang Xian-Ming
Published: February 2023

Background

The global epidemiological situation of COVID-19 remains serious. The rapid hunting of SARS-CoV-2 infection is the key means for preventing transmission.

Methods

A total of 40,689 consecutive overseas arrivals were screened for SARS-CoV-2 infection based on PCR and serologic testing. The yield and efficiency of different screening algorithms were evaluated.

Result

Among the 40,689 consecutive overseas arrivals, 56 (0.14%) subjects were confirmed to have SARS-CoV-2 infection. The asymptomatic rate was 76.8%. When the algorithm based on PCR alone was used, the identification yield of a single round of PCR (PCR1) was only 39.3% (95% CI: 26.1–52.5%). It took at least four rounds of PCR to achieve a yield of 92.9% (95% CI: 85.9–99.8%). Fortunately, an algorithm based on a single round of PCR combined with a single round of serologic testing (PCR1+ Ab1) greatly improved the screening yield to 98.2% (95% CI: 94.6–100.0%) and required 42,299 PCR and 40,689 serologic tests that cost 6,052,855 yuan. By achieving a similar yield, the cost of PCR1+ Ab1 was 39.2% of that of four rounds of PCR. For hunting one case in PCR1+ Ab1, 769 PCR and 740 serologic tests were required, costing 110,052 yuan, which was 63.0% of that of the PCR1 algorithm.

Conclusion

Comparing an algorithm based on PCR alone, PCR combined with a serologic testing algorithm greatly improved the yield and efficiency of the identification of SARS-CoV-2 infection.
Model-based risk assessment of dengue fever transmission in Xiamen City, China
Authors: Guo Zhinan , Liu Weikang , Liu Xingchun , Abudunaibi Buasiyamu , Luo Li , Wu Sihan , Deng Bin , Yang Tianlong , Huang Jiefeng , Wu Shenggen , Lei Lei , Zhao Zeyu , Li Zhuoyang , Li Peihua , Liu Chan , Zhan Meirong , Chen Tianmu
Published: February 2023

Background

Quantitative assessment of the risk of local transmission from imported dengue cases makes a great challenge to the development of public health in China. The purpose of this study is to observe the risk of mosquito-borne transmission in Xiamen City through ecological and insecticide resistance monitoring. Quantitative evaluation of mosquito insecticide resistance, community population and the number of imported cases affecting the transmission of dengue fever (DF) in Xiamen was carried out based on transmission dynamics model, so as to reveal the correlation between key risk factors and DF transmission.

Methods

Based on the dynamics model and combined with the epidemiological characteristics of DF in Xiamen City, a transmission dynamics model was built to simulate the secondary cases caused by imported cases to evaluate the transmission risk of DF, and to explore the influence of mosquito insecticide resistance, community population and imported cases on the epidemic situation of DF in Xiamen City.

Results

For the transmission model of DF, when the community population is between 10,000 and 25,000, changing the number of imported DF cases and the mortality rate of mosquitoes will have an impact on the spread of indigenous DF cases, however, changing the birth rate of mosquitoes did not gain more effect on the spread of local DF transmission.

Conclusions

Through the quantitative evaluation of the model, this study determined that the mosquito resistance index has an important influence on the local transmission of dengue fever caused by imported cases in Xiamen, and the Brayton index can also affect the local transmission of the disease.
The impact of COVID-19 quarantine on lifestyle indicators in the United Arab Emirates
Authors: AlBlooshi Sharifa , AlFalasi Maryam , Taha Zainab , El Ktaibi Farid , Khalid Alia
Published: February 2023

Introduction

COVID-19 is a virus that has spread rapidly and brought economic and social crises all around the world. The current study aimed to investigate the impact of COVID-19 quarantine on dietary habits, physical activity, food purchasing, smoking, and sleeping patterns in the United Arab Emirates.

Methods

A cross-sectional study was conducted using an online questionnaire between November 1st, 2020 and the end of January 2021. Citizens and residents of the UAE aged ≥ 18 years old were asked to complete an anonymous electronic questionnaire created via Google Forms and distributed on various platforms, such as WhatsApp, Twitter, and email. A total of 1682 subjects participated in the study.

Results

The results included that during the COVID-19 lockdown, more participants (44.4%) reported an increase in weight. This gain seems to be linked to increased food consumption [(Adjusted Odd Ratio) AOR = 1.68, 95% (Confidence Interval) CI = 1.12, 2.54,p= 0.022], decreased physical activity (AOR = 2.25, 95% CI = 1.58, 3.21,p< 0.001), and increased smoking (AOR = 1.90, 95% CI = 1.04, 3.50,p= 0.038). The groups that were most likely to gain weight included those who consumed more cereals (AOR = 1.67, 95% CI = 1.08, 2.57,p= 0.011), had an increased desire for sweets (AOR = 2.19, 95% CI = 1.50, 3.19,p< 0.001), and an increased desire for food (hunger) (AOR = 2.19, 95% CI = 1.53, 3.14,p< 0.001). In contrast, those who exercised more were more likely to lose weight (AOR = 0.61, 95% CI = 0.44, 0.86,p< 0.001) as well as those who slept over 9 h a day (AOR = 1.90, 95% CI = 0.45, 0.88,p= 0.006).

Discussion

Overall, it is essential to promote healthy habits and methods of healthy diet maintenance during stressful and unusual times when people might find it difficult to put effort into their health.