bluuebunny/crossref_metadata_2025 huggingface dataset:
Character Strengths Predict Subjective Well-Being, Psychological Well-Being, and Psychopathological Symptoms, Over and Above Functional Social Support
Authors: Azañedo Carolina M. , Artola Teresa , Sastre Santiago , Alvarado Jesús M.
Published: September 2021

The increasing value of character strengths in the prediction of well-being and psychopathology, after the effects of functional social support and sociodemographic variables are accounted for, is examined. Participants were 1494 Spanish-speaking students between the ages of 18 and 68 (43.3% men and 56.7% women) who completed measures of character strengths, functional social support, subjective well-being, psychological well-being, and symptoms of psychopathology. Functional social support had predictive value in explaining the variability of each component of well-being and psychopathology. Regarding character strengths, theological strengths had the greatest predictive power for life satisfaction (β = 0.41), positive affect (β = 0.49), affect balance (β = 0.45), purpose in life (β = 0.60), self-acceptance (β = 0.50), environmental mastery (β = 0.47), and positive relations with others (β = 0.25). Emotional strengths made the strongest contribution to the variance explained (β = 0.41) of autonomy, and intellectual strengths were the strongest predictive variable for personal growth (β = 0.39). Strengths of restraint had the greatest predictive power for the global severity index of psychopathology (β = –0.27). Functional social support and character strengths have strong links to mental health. Positive interventions to develop these variables could contribute to enhance well-being and prevent psychological distress.
Match-Fixing Causing Harm to Athletes on a COVID-19-Influenced Gambling Market: A Call for Research During the Pandemic and Beyond
Authors: Håkansson A , Jönsson C , Kenttä G
Published: September 2021

Match-fixing, although not a new problem, has received growing attention during the COVID-19 pandemic, which has been reported in the media to have increased the risk of match-fixing events. Gambling is a well-documented addictive behavior, and gambling-related fraud, match-fixing, is a challenge to the world of sports. Most research on match-fixing has a judicial or institutional perspective, and few studies focus on its individual consequences. Nevertheless, athletes may be at particular risk of mental health consequences from the exposure to or involvement in match-fixing. The COVID-19 crisis puts a spotlight on match-fixing, as the world of competitive sports shut down or changed substantially due to pandemic-related restrictions. We call for research addressing individual mental health and psycho-social correlates of match-fixing, and their integration into research addressing problem gambling, related to the pandemic and beyond.
Obesity and Mental Health: A Longitudinal, Cross-Cultural Examination in Germany and China
Authors: Lavallee Kristen L. , Zhang Xiao Chi , Schneider Silvia , Margraf Jürgen
Published: September 2021

The present study examines the relationship between obesity and mental health using longitudinal data. Participants with data at baseline and one-year follow-up were included from two countries: Germany (364) and China (9007). A series of structural equation models with three mediators and one moderator were conducted separately for female and male students in Germany and China. Zero-order correlations indicated that overweight/obesity was significantly related to later depression and anxiety in Chinese males. Additional effects of obesity on later mental health flowed through effects on attractiveness (Chinese and German females, and Chinese males), physical health (Chinese males), and life satisfaction (German females). Though overweight/obesity is related to mental health across many other studies, results in this study yield total effects between overweight/obesity and follow-up mental health only in Chinese males. The relationship between overweight/obesity and follow-up mental health was significantly mediated by follow-up attractiveness, or health state, or life satisfaction in German females, Chinese females, and Chinese male students, with no significant indirect effects found in German male students. This highlights the possible importance of culture in examining these effects.
Resetting of Auditory and Visual Segregation Occurs After Transient Stimuli of the Same Modality
Authors: Higgins Nathan C. , Monjaras Ambar G. , Yerkes Breanne D. , Little David F. , Nave-Blodgett Jessica E. , Elhilali Mounya , Snyder Joel S.
Published: September 2021

In the presence of a continually changing sensory environment, maintaining stable but flexible awareness is paramount, and requires continual organization of information. Determining which stimulus features belong together, and which are separate is therefore one of the primary tasks of the sensory systems. Unknown is whether there is a global or sensory-specific mechanism that regulates the final perceptual outcome of this streaming process. To test the extent of modality independence in perceptual control, an auditory streaming experiment, and a visual moving-plaid experiment were performed. Both were designed to evoke alternating perception of an integrated or segregated percept. In both experiments, transient auditory and visual distractor stimuli were presented in separate blocks, such that the distractors did not overlap in frequency or space with the streaming or plaid stimuli, respectively, thus preventing peripheral interference. When a distractor was presented in the opposite modality as the bistable stimulus (visual distractors during auditory streaming or auditory distractors during visual streaming), the probability of percept switching was not significantly different than when no distractor was presented. Conversely, significant differences in switch probability were observed following within-modality distractors, but only when the pre-distractor percept was segregated. Due to the modality-specificity of the distractor-induced resetting, the results suggest that conscious perception is at least partially controlled by modality-specific processing. The fact that the distractors did not have peripheral overlap with the bistable stimuli indicates that the perceptual reset is due to interference at a locus in which stimuli of different frequencies and spatial locations are integrated.
Sickness Presenteeism Among the Swedish Self-Employed During the Covid-19 Pandemic
Authors: Vinberg Stig , Landstad Bodil J. , Tjulin Åsa , Nordenmark Mikael
Published: September 2021

The present study analyzed the impact of business operations, work and family circumstances, and well-being on the risk of sickness presenteeism for Swedish self-employed workers during the Covid-19 pandemic. It is of great importance to investigate the impact of the pandemic on the self-employed and their enterprises because they are seen as key drivers of economic growth and constitute an expanding group in many countries. Data were obtained from 845 self-employed workers by a web-based survey including questions about background information, work and family circumstances, well-being, sickness presenteeism, and questions about the pandemic. Results were that around 40% of the self-employed introduced new products, processes, and marketing methods, and just over 50% attempted to get new customers during the pandemic. Nearly half of the self-employed people reported that they lost contracts, and 22% judged the risk of bankruptcy to be quite or highly likely. Regression analyses showed that the more the self-employed reported impact on business indicators, increased work hours, a higher level of work-family conflict, and a lower level of mental well-being, the higher the risk of sickness presenteeism. The most common reasons given by the participants for sickness presenteeism during the pandemic were “nobody else can carry out my responsibilities,” “I can't afford to take sick leave” and “I enjoy my work.” Conclusions are that a critical event such as the pandemic probably adds to an already high workload for the self-employed. Impact on business operations such as developing new products/services and marketing, risk of bankruptcy and increased work hours seems to be important factors for explaining sickness presenteeism among the self-employed. Theoretical contributions from the study suggest that critical events such as the Covid-19 pandemic should be considered as an important environmental factor when studying sickness presenteeism among self-employed.
Suffering Job Insecurity: Will the Employees Take the Proactive Behavior or Not?
Authors: Yao Xun , Li Meng , Zhang Huiqin
Published: September 2021

Job insecurity is considered an important antecedent of an employee’s creativity. Though, the relationship between job insecurity and proactive behavior has been neglected in previous human resources management studies. The aim of this study is to explore the influence of job insecurity on employees’ proactive behavior and its mechanism. Based on the social cognitive theory and cognitive appraisal theory, two types of cognitive appraisal of employee’s job insecurity (hindrance vs. challenge) as mediator variables of job insecurity and proactive behavior association. In addition, the moderator roles of self-efficacy are examined. This study is carried out with 257 employees from Chinese firms to examine the hypothesized moderated mediation model by using the hierarchical regression analysis and the bootstrap. The results showed a different effect of job insecurity depending on its conceptualization. The results show that job insecurity has a negative effect on employees’ proactive behavior. At the same time, cognitive appraisal of employees’ job insecurity mediated the association between job insecurity and employee’s proactive behavior. Self-efficacy not only moderates the relationship between job insecurity and cognitive appraisal but also moderate the cognitive appraisal’s mediation effect between job insecurity and proactive behavior. The study’s theoretical and practical contributions and future research are discussed.
Would It Be Better if Instructors Technically Adjust Their Image or Voice in Online Courses? Impact of the Way of Instructor Presence on Online Learning
Authors: Yuan Mingze , Zeng Jialing , Wang Aihua , Shang Junjie
Published: September 2021

This study investigated the effects of the changes in the image and voice of instructors in online video courses on online learner's learning achievement, social presence, learning satisfaction, and academic emotion. Two simultaneous online experiments were conducted with 122 college students in the image experiment, where the course videos varied in terms of the instructor's image (original image, face-beautified image, virtual image, and no image), and 93 college students in the voice experiment, where the course videos varied in terms of the instructor's voice (original voice, mutated voice, computer-synthesized voice). The results showed that learners viewing videos without instructor images had better learning achievements and less academic boredom relative to those who viewed videos with instructor images. However, the real instructor images were able to promote learners' learning satisfaction of instructor-student interaction more than no image and virtual image and promote satisfaction of instructor teaching more than virtual image. Meanwhile, learners' evaluation of the real instructor images was better than that of the virtual instructor image, and their evaluation of the face-beautified instructor image was better than the original image. Moreover, learners evaluated real instructor voices better than the computer-synthesized voice. In addition, the linear regression analysis revealed that the evaluations of both instructor's image and voice had a positive relationship with learners' social presence, learning satisfaction, and enjoyment, whereas they had a negative relationship with learner's boredom. And the evaluation of the instructor's image positively predicted student's transfer learning achievement. Thus, we suggested that the way of instructor presence should be well-designed and integrated with the course's instructional design and image and voice processing technology can be applied to assist online video course development.
The Impact of COVID-19 on Sleep in Autistic Adults: Longitudinal Comparisons pre and During Lockdown
Authors: Halstead Elizabeth J. , Sullivan Emma C. , Dimitriou Dagmara
Published: September 2021

Background: The longer-term impact of the pandemic on autistic adults' sleep are yet to be revealed, with studies concentrating on sleep in autistic children or mental health outcomes and coping strategies of autistic adults. Given the prevalence of sleep problems experienced by autistic adults and the changes in routine that have occurred as a result of COVID-19 societal restrictions, this study assessed the impact of the COVID-19 pandemic on sleep problems via a longitudinal subjective assessment method.

Methods: Sleep data were gathered at three time points from 95 autistic adults, namely prior to the pandemic, at the start of COVID-19 and several months into COVID-19 to obtain a rich longitudinal dataset ascertaining how/if sleep patterns have changed in autistic adults over these several months.

Results: In comparison to pre-lockdown, several sleep components were shown to improve during the lockdown. These improvements included reduced sleep latency (time taken to fall asleep), longer sleep duration, improved sleep efficiency, improved sleep quality, as well as improved daytime functioning. Pre-sleep cognitive arousal scores were found to decrease compared to pre-lockdown, meaning cognitive arousal improved. Approximately 65% of participants reported that they felt their sleep had been impacted since COVID-19 since Time 1, with the most common reasons reported as waking up exhausted (36.92%), not being able to get to sleep (33.85%), waking up in the night (29.23%), having a disrupted sleep pattern (27.69%), and nightmares (18.46%).

Conclusions: Improvements in sleep may be related to societal changes (e.g., working from home) during the pandemic. Some of these changes are arguably beneficial for autistic adults in creating a more autism-inclusive society, for example telehealth opportunities for care. Further exploration of the associations between mental health and sleep are warranted.
Effects of Coronavirus-19 Induced Loneliness on Mental Health: Sleep Quality and Intolerance for Uncertainty as Mediators
Authors: Gu Simeng , He Zhengming , Sun Lianwang , Jiang Yao , Xu Minghong , Feng Guangkui , Ma Xianjun , Wang Fushun , Huang Jason H.
Published: September 2021

Objective: The aim of the study is to investigate effects of loneliness on individual's mental health and the mediating effects of intolerance of uncertainty and sleep quality in the post Coronavirus-19 period, especially for the young people.

Methods: The questionnaires used in this study include UCLA loneliness scale (UCLA-3), the Pittsburgh Sleep Quality Index (PSQI), intolerance for uncertainty (IU) and the Chinese version of DASS-21. A total number of 289 subjects were recruited in the study, which includes 209 females (72.3%), 80 males (27.7%); and 212 students (73.4%), 77 working staffs (26.6%).

Results: The results showed that: (1) people have high levels of loneliness, anxiety, depression and stress, and poor sleep quality; (2) the mediating effect of intolerance for uncertainty in the relationship of loneliness and mental health is significant (effect size = 0.178, 95% CI confidence interval: [0.115, 0.241]), and the mediating effects of sleep quality in the relationship between loneliness and mental health is significant (effect size = 0.127, 95% CI confidence interval: [0.017, 0.239]).

Conclusion: Loneliness invokes a stronger self-concerned inadaptability to threat response and may lead to more mental diseases through more serious intolerance for uncertainty and insomnia.
COVID-19 Outbreaks in Settings With Precarious Housing Conditions in Germany: Challenges and Lessons Learned
Authors: Zimmermann Ruth , Sarma Navina , Thieme-Thörel Doris , Alpers Katharina , Artelt Tanja , Azouagh Karima , Bremer Viviane , Broistedt Petra , Eckmanns Tim , Feltgen Nicolas , Huska Matthew , Kröger Stefan , Puls Angelika , Scheithauer Simone , Mayr Eckart , Rexroth Ute
Published: September 2021

Two COVID-19 outbreaks occurred in residential buildings with overcrowded housing conditions in the city of Göttingen in Germany during May and June 2020, when COVID-19 infection incidences were low across the rest of the country, with a national incidence of 2.6/100,000 population. The outbreaks increased the local incidence in the city of Göttingen to 123.5/100,000 in June 2020. Many of the affected residents were living in precarious conditions and experienced language barriers. The outbreaks were characterized by high case numbers and attack rates among the residents, many asymptomatic cases, a comparatively young population, and substantial outbreak control measures implemented by local authorities. We analyzed national and local surveillance data, calculated age-, and gender-specific attack rates and performed whole genome sequencing analysis to describe the outbreak and characteristics of the infected population. The authorities' infection control measures included voluntary and compulsory testing of all residents and mass quarantine. Public health measures, such as the general closure of schools and a public space as well as the prohibition of team sports at local level, were also implemented in the district to limit the outbreaks locally. The outbreaks were under control by the end of June 2020. We describe the measures to contain the outbreaks, the challenges experienced and lessons learned. We discuss how public health measures can be planned and implemented through consideration of the needs and vulnerabilities of affected populations. In order to avoid coercive measures, barrier-free communication, with language translation when needed, and consideration of socio-economic circumstances of affected populations are crucial for controlling infectious disease transmission in an outbreak effectively and in a timely way.
Flood Impact Assessments on Transportation Networks: A Review of Methods and Associated Temporal and Spatial Scales
Authors: Rebally Aditya , Valeo Caterina , He Jianxun , Saidi Saeid
Published: September 2021

A region's transportation sector is vital to its economic and social health. Transportation systems are also influenced by climate change directly and indirectly and on a variety of spatial and temporal scales. Under a changing climate, many regions around the globe and especially in urban areas, have experienced increases in flood intensity and frequency in recent decades. Flooding can strain transportation networks in both the short- and long-term through transportation delays, infrastructure damage, and recovery, and potentially affect economies. The present article is a review of how flooding impacts transportation networks in both short- and long-term timescales and their subsequent impact on resiliency of the network. Firstly, flood effects are classified based on the connections between the type of flooding and the type of impact (either direct or indirect) on the transportation system. An analysis of the assessment methods and the transport models used to formulate flood effects on the transportation system is provided, as well as the drawbacks from the context of timescales, and recommendations for future research. The analysis indicates that the majority of the articles assess the direct and tangible impacts with focus on the resilience of the transportation network in short- and medium-term temporal scales and at smaller spatial scales. There is less emphasis on indirect, intangible flood impacts, and long-term temporal scales.
Macroplastic Debris Transfer in Rivers: A Travel Distance Approach
Authors: Newbould Robert A. , Powell D. Mark , Whelan Michael J.
Published: September 2021

Plastic accumulation in the marine environment is a major concern given the harmful effects and longevity of plastics at sea. Although rivers are likely to significantly contribute to the flux of plastic to marine systems, the behaviour of plastic debris in fluvial systems remains poorly understood and estimates of riverine plastic flux derived from field measurements and modelling efforts are highly uncertain. This paper presents a new probabilistic model of plastic transport in rivers which describes the main processes controlling plastic displacement and which predicts the statistical distribution of travel distances for individual items of buoyant macroplastic debris. Macroplastic transport is controlled by retention in temporary stores (or traps) created by vegetation, bank roughness elements and other obstacles. The behaviour of these traps is represented in the model via a series of Bernoulli trials conducted in a Monte Carlo simulation framework. The model was applied to a tracer experiment in a small 1.1 km river reach. Three replicates were used for calibration and three for validation. For each replicate, 90 closed air-filled polyethylene terephthalate (PET) bottles were introduced at the upstream end of the reach and the location of each bottle was recorded after 24 h. Bottles were chosen as “model” macroplastic litter items given their high usage and littering rate. Travel distances were low. The average and maximum distances travelled over 24 h were 231 m and 1.1 km, respectively. They were also variable. The coefficient of variation of travel distances was 0.94. Spatial patterns were controlled by the location and characteristics of discrete traps. The model was able to describe the observed travel distance distributions reasonably well, suggesting that modelling plastic behaviour in longer reaches and even whole catchments using a stochastic travel distance approach is feasible. The approach has the potential to improve estimates of river plastic flux, although significant knowledge gaps remain (e.g., the rate and location of plastic supply to river systems, the transport behaviours of different types of plastic debris and trap effectiveness in different types of river system, season, and discharge).
No Correlation Between Plantar Flexor Muscle Volume and Sprint Performance in Sprinters
Authors: Miyake Yuto , Suga Tadashi , Terada Masafumi , Tanaka Takahiro , Ueno Hiromasa , Kusagawa Yuki , Otsuka Mitsuo , Nagano Akinori , Isaka Tadao
Published: September 2021

The plantar flexor torque plays an important role in achieving superior sprint performance in sprinters. Because of the close relationship between joint torque and muscle size, a simple assumption can be made that greater plantar flexor muscles (i.e., triceps surae muscles) are related to better sprint performance. However, previous studies have reported the absence of these relationships. Furthermore, to examine these relationships, only a few studies have calculated the muscle volume (MV) of the plantar flexors. In this study, we hypothesized that the plantar flexor MVs may not be important morphological factors for sprint performance. To test our hypothesis, we examined the relationships between plantar flexor MVs and sprint performance in sprinters. Fifty-two male sprinters and 26 body size-matched male non-sprinters participated in this study. On the basis of the personal best 100 m sprint times [range, 10.21–11.90 (mean ± SD, 11.13 ± 0.42) s] in sprinters, a K-means cluster analysis was applied to divide them into four sprint performance level groups (n = 8, 8, 19, and 17 for each group), which was the optimal number of clusters determined by the silhouette coefficient. The MVs of the gastrocnemius lateralis (GL), gastrocnemius medialis (GM), and soleus (SOL) in participants were measured using magnetic resonance imaging. In addition to absolute MVs, the relative MVs normalized to body mass were used for the analyses. The absolute and relative MVs of the total and individual plantar flexors were significantly greater in sprinters than in non-sprinters (all p < 0.01, d = 0.64–1.39). In contrast, all the plantar flexor MV variables did not differ significantly among the four groups of sprinters (all p > 0.05, η2 = 0.02–0.07). Furthermore, all plantar flexor MV variables did not correlate significantly with personal best 100 m sprint time in sprinters (r = −0.253–0.002, all p > 0.05). These findings suggest that although the plantar flexor muscles are specifically developed in sprinters compared to untrained non-sprinters, the greater plantar flexor MVs in the sprinters may not be important morphological factors for their sprint performance.
Microbial Community Diversity Dynamics in Acid Mine Drainage and Acid Mine Drainage-Polluted Soils: Implication on Mining Water Irrigation Agricultural Sustainability
Authors: Munyai Rabelani , Ogola Henry Joseph Oduor , Modise David Mxolisi
Published: September 2021

Environmental degradation related to mining-generated acid mine drainage (AMD) is a major global concern, contaminating surface and groundwater sources, including agricultural land. In the last two decades, many developing countries are expanding agricultural productivity in mine-impacted soils to meet food demand for their rapidly growing population. Further, the practice of AMD water (treated or untreated) irrigated agriculture is on the increase, particularly in water-stressed nations around the world. For sustainable agricultural production systems, optimal microbial diversity, and functioning is critical for soil health and plant productivity. Thus, this review presents up-to-date knowledge on the microbial structure and functional dynamics of AMD habitats and AMD-impacted agricultural soils. The long-term effects of AMD water such as soil acidification, heavy metals (HM), iron and sulfate pollution, greatly reduces microbial biomass, richness, and diversity, impairing soil health plant growth and productivity, and impacts food safety negatively. Despite these drawbacks, AMD-impacted habitats are unique ecological niches for novel acidophilic, HM, and sulfate-adapted microbial phylotypes that might be beneficial to optimal plant growth and productivity and bioremediation of polluted agricultural soils. This review has also highlighted the impact active and passive treatment technologies on AMD microbial diversity, further extending the discussion on the interrelated microbial diversity, and beneficial functions such as metal bioremediation, acidity neutralization, symbiotic rhizomicrobiome assembly, and plant growth promotion, sulfates/iron reduction, and biogeochemical N and C recycling under AMD-impacted environment. The significance of sulfur-reducing bacteria (SRB), iron-oxidizing bacteria (FeOB), and plant growth promoting rhizobacteria (PGPRs) as key players in many passive and active systems dedicated to bioremediation and microbe-assisted phytoremediation is also elucidated and discussed. Finally, new perspectives on the need for future studies, integrating meta-omics and process engineering on AMD-impacted microbiomes, key to designing and optimizing of robust active and passive bioremediation of AMD-water before application to agricultural production is proposed.
Impact of Oral Hygiene on Prognosis in Patients With Squamous Cell Carcinoma of the Lower Gingiva
Authors: Zhao Hui , Zhang Shengnan , Ma Jinji , Sun Xiaodong
Published: September 2021

Objective: We aimed to analyze the significance of oral hygiene in patients with squamous cell carcinoma of the lower gingiva.

Methods: Oral hygiene was assessed using a questionnaire by calculating the oral health (OH) score and the dental care (DC) score. The association of oral hygiene with clinical pathologic variables, disease free survival (DFS), and overall survival (OS) was analyzed.

Results: Four out of 53 non-smokers and 19 out of 90 current or former smokers had an OH score of 6 (statistically significant difference, p = 0.036). Fifteen out of 63 patients with a T3/T4 tumor and 8 out of 80 patients with a T1/T2 tumor had an OH score of 6 (statistically significant difference, p = 0.026). Similar statistically significant findings were noted with respect to the DC scores, smoking status, and tumor stage. Among patients with an OH score of 0–5, the 5-year DFS and OS rates were 55 and 50%, respectively, and among patients with an OH score >5, they were 46 and 43%, respectively (both differences statistically significant, p < 0.05). Among patients with a DC score of 0–2, the 5-year DFS and OS rates were 69 and 51%, respectively and among patients with a DC score >2, they were 50 and 47%, respectively (both differences statistically significant, p < 0.05). Cox model confirmed OH and DC scores as independent factors affecting the DFS and OS.

Conclusion: Poor oral hygiene was associated with decreased DFS and OS.
A Cross-Sectional Survey of the Knowledge, Attitudes, and Practices of Antimicrobial Users and Providers in an Area of High-Density Livestock-Human Population in Western Kenya
Authors: Kemp Steven A. , Pinchbeck Gina L. , Fèvre Eric M. , Williams Nicola J.
Published: September 2021

Background: Antimicrobial resistance (AMR) is one of the most important global health crises in recent times and is driven primarily by antimicrobial consumption. In East Africa, there is a paucity of data regarding the knowledge, attitudes, and practices (KAP) related to antimicrobial use (AMU). We investigate the ways in which antimicrobial users in the veterinary sector accessed veterinary antimicrobials, and common behaviors of veterinary antimicrobial users and prescribers associated with AMU and AMR.

Methods: In total, 70 farmers, staff at 49 agricultural-veterinary antimicrobial shops (agrovet staff) and 28 veterinary animal healthcare workers or veterinary surgeons (veterinary professionals) were interviewed in Busia county, western Kenya in 2016 using a standard questionnaire as a framework for structured interviews. Data recorded included participant demographics, level of education, access to and sources of veterinary antimicrobials, prescribing patterns, and knowledge of AMR and antimicrobial withdrawal periods.

Results: The majority of antimicrobials were accessed through informal means, purchased from agroveterinary shops; more than half of staff did not hold nationally mandated qualifications to advise on or sell veterinary antimicrobials. Approximately 40% of veterinary antimicrobials were sold without a prescription and it was noted that both price and customer preference were important factors when selling antimicrobials in almost all agrovet shops. Knowledge of the dangers associated with AMR and AMU were mostly superficial. Treatment failure occurred often, and there was a lack of differentiation between AMR and simply treatment failure.

Conclusion: In this study area in East Africa with high-density human and livestock populations, AMU was primarily for maintenance of livestock health. These findings have highlighted several aspects surrounding inappropriate access to antimicrobials, and as such require attention from policy makers concerned with AMR in both livestock and human medicine sectors. Improving prescribing practices and ensuring a minimum level of general education and awareness of prescribers, as well as expanding the role of agrovet staff in antimicrobial stewardship programmes, may help begin to mitigate the maintenance and transmission of AMR, particularly amongst livestock.
Advanced Design and Optimal Sizing of Hydrostatic Transmission Systems
Authors: Guo Xiaofan , Vacca Andrea
Published: September 2021

This paper presents a novel method for designing and sizing high-efficient hydrostatic transmissions (HTs) for heavy duty propulsion applications such as agricultural and construction machinery. The proposed method consists in providing cost effective HT architectures that maximizes efficiency at the most frequent operating conditions of the transmission, as opposed to the traditional HT design methods based on the most demanding requirements of the system. The sizing method is based on a genetic optimization algorithm for calculating the optimal displacement of the main units of the HT to maximizes the efficiency in the most frequent operating conditions of the vehicle. A simulation model for HTs is built in MATLAB/Simulink® environment to test three different circuit alternatives for basic HTs. Considering a particular 250 kW heavy-duty application for which drive cycle data were available, this study shows great improvement in energy efficiency (14%) and power saving (20.1%) at frequent operating conditions while still achieving the corner power condition.
A Gimballed Control Moment Gyroscope Cluster Design for Spacecraft Attitude Control
Authors: Papakonstantinou Charalampos , Lappas Vaios , Kostopoulos Vassilis
Published: September 2021

This paper addresses the problem of singularity avoidance in a cluster of four Single-Gimbal Control Moment Gyroscopes (SGCMGs) in a pyramid configuration when used for the attitude control of a satellite by introducing a new gimballed control moment gyroscope (GCMG) cluster scheme. Four SGCMGs were used in a pyramid configuration, along with an additional small and simple stepper motor that was used to gimbal the full cluster around its vertical (z) axis. Contrary to the use of four variable-speed control moment gyroscopes (VSCMGs), where eight degrees of freedom are available for singularity avoidance, the proposed GCMG design uses only five degrees of freedom (DoFs), and a modified steering law was designed for the new setup. The proposed design offers the advantages of SGCMGs, such as a low weight, size, and reduced complexity, with the additional benefit of overcoming the internal elliptic singularities, which create a minor attitude error. A comparison with the four-VSCMG cluster was conducted through numerical simulations, and the results indicated that the GCMG design was considerably more efficient in terms of power while achieving a better gimbal configuration at the end of the simulation, which is essential when it is desired for different manoeuvres to be consecutively executed. Additionally, for a nano-satellite of a few kilograms, the results prove that it is feasible to manufacture the GCMG concept by using affordable and lightweight commercial off-the-shelf (COTS) stepper motors.
Heads and Tails: An Analysis of Visual Signals in Cats, Felis catus
Authors: Deputte Bertrand L. , Jumelet Estelle , Gilbert Caroline , Titeux Emmanuelle
Published: September 2021

Visual communication involves specific signals. These include the different positions of mobile body elements. We analyzed visual configurations in cats that involve ears and the tail. We aimed at deciphering which features of these configurations were the most important in cats’ interactions with other cats and with humans. We observed a total of 254 cat–cat interactions within a sample of 29 cats, during a total of 100 h of observation scheduled with the “Behavioral dependent onset of sampling” method and using the “All occurences” sampling method. In addition, we sampled 10 interactions between cats and humans. In cat–cat interactions, we noted the positions of ears and tail of both protagonists, as well as the outcome of the interaction, which was either positive/neutral or negative. In a great majority of the 254 interactions sampled, both cats held their tail down. On the contrary, ear position was a critical element in predicting the outcome. When both partners held their ears erect, the outcome was significantly positive, such as rubbing or close proximity. In all other cases of the position of ears in both cats, the outcome was negative, with increased distance of the partners. Although the tail did not seem to play a significant role in visual configurations in cat interactions, the “tail-up” display was important when a cat approached a human being. In the vast majority of cases the cat rubbed itself on a human’s leg(s). Thus, we may conclude that the presence of a human has a specific meaning in the cat’s world, probably as the result of a long period of commensalism. It is important for pet owners to understand the signals that cats use with other cats and with humans in order to promote the welfare of cats.
Prevalence and Antibiotic Resistance Profile of Bacterial Pathogens in Aerobic Vaginitis: A Retrospective Study in Italy
Authors: Serretiello Enrica , Santella Biagio , Folliero Veronica , Iervolino Domenico , Santoro Emanuela , Manente Roberta , Dell’Annunziata Federica , Sperlongano Rossella , Crudele Valeria , De Filippis Anna , Galdiero Massimiliano , Franci Gianluigi , Boccia Giovanni
Published: September 2021

Aerobic vaginitis (AV) is a vaginal infectious condition, characterized by a high inflammatory response and/or signs of epithelial atrophy, a decrease in the amount of Lactobacillus spp. and an increase in enteric origin bacteria. AV, often misdiagnosed, is difficult to treat due to the emerging spread of multi-drug resistant bacterial strains. The present study aimed to define the prevalence of AV, to detect causative bacteria and their antimicrobial resistance pattern. Women 10–95 years old, admitted to San Giovanni di Dio e Ruggi d’Aragona Hospital, Salerno, Italy (in the years 2015–2019) are included in the study. Bacterial identification and antibiotic susceptibility tests were carried out by VITEK® 2. Among 2069 patients, 1176 tested positive for microbial growth. A higher incidence of infection was found in the 55–64 age group. Among the pathogenic strains, 50.4% were Gram-negative, and 49.6% were Gram-positive. Escherichia coli (E. coli) (32.5%) was the most representative strain, followed by Enterococcus faecalis (E. faecalis) (29.4%), Klebsiella pneumoniae (K. pneumoniae) (7.8%) and Enterococcus faecium (E. faecium) (7.7%). E. coli showed high sensitivity to carbapenems and amikacin. K. pneumoniae carbapenems resistance was fluctuating over time. Alarming resistance to vancomycin was not recorded for Enterococci. Both strains were sensitive to teicoplanin, linezolid and tigecycline. Proper diagnosis and an effective therapeutic approach are needed to improve AV management.
No Correlation between Biofilm Formation, Virulence Factors, and Antibiotic Resistance in Pseudomonas aeruginosa: Results from a Laboratory-Based In Vitro Study
Authors: Gajdács Márió , Baráth Zoltán , Kárpáti Krisztina , Szabó Dóra , Usai Donatella , Zanetti Stefania , Donadu Matthew Gavino
Published: September 2021

Pseudomonas aeruginosa (P. aeruginosa) possesses a plethora of virulence determinants, including the production of biofilm, pigments, exotoxins, proteases, flagella, and secretion systems. The aim of our present study was to establish the relationship between biofilm-forming capacity, the expression of some important virulence factors, and the multidrug-resistant (MDR) phenotype in P. aeruginosa. A total of three hundred and two (n = 302) isolates were included in this study. Antimicrobial susceptibility testing and phenotypic detection of resistance determinants were carried out; based on these results, isolates were grouped into distinct resistotypes and multiple antibiotic resistance (MAR) indices were calculated. The capacity of isolates to produce biofilm was assessed using a crystal violet microtiter-plate based method. Motility (swimming, swarming, and twitching) and pigment-production (pyoverdine and pyocyanin) were also measured. Pearson correlation coefficients (r) were calculated to determine for antimicrobial resistance, biofilm-formation, and expression of other virulence factors. Resistance rates were the highest for ceftazidime (56.95%; n = 172), levofloxacin (54.97%; n = 166), and ciprofloxacin (54.64%; n = 159), while lowest for colistin (1.66%; n = 5); 44.04% (n = 133) of isolates were classified as MDR. 19.87% (n = 60), 20.86% (n = 63) and 59.27% (n = 179) were classified as weak, moderate, and strong biofilm producers, respectively. With the exception of pyocyanin production (0.371 ± 0.193 vs. non-MDR: 0.319 ± 0.191; p = 0.018), MDR and non-MDR isolates did not show significant differences in expression of virulence factors. Additionally, no relevant correlations were seen between the rate of biofilm formation, pigment production, or motility. Data on interplay between the presence and mechanisms of drug resistance with those of biofilm formation and virulence is crucial to address chronic bacterial infections and to provide strategies for their management.
In Situ Quantification of Polyhydroxybutyrate in Photobioreactor Cultivations of Synechocystis sp. Using an Ultrasound-Enhanced ATR-FTIR Spectroscopy Probe
Authors: Doppler Philipp , Gasser Christoph , Kriechbaum Ricarda , Ferizi Ardita , Spadiut Oliver
Published: September 2021

Polyhydroxybutyrate (PHB) is a very promising alternative to most petroleum-based plastics with the huge advantage of biodegradability. Biotechnological production processes utilizing cyanobacteria as sustainable source of PHB require fast in situ process analytical technology (PAT) tools for sophisticated process monitoring. Spectroscopic probes supported by ultrasound particle traps provide a powerful technology for in-line, nondestructive, and real-time process analytics in photobioreactors. This work shows the great potential of using ultrasound particle manipulation to improve spectroscopic attenuated total reflection Fourier-transformed mid-infrared (ATR-FTIR) spectra as a monitoring tool for PHB production processes in photobioreactors.
Effects of Ethanol Exposure during Lactation on Ultrasonic Vocalizations of Rat Pups upon Their Isolation: Increase in Pup Distress Calls
Authors: Shahrier Mohd. Ashik , Wada Hiromi
Published: September 2021

Recording ultrasonic vocalizations (USVs) is a highly sensitive tool to study the dam–pup social relationships, and USV recordings have been used to study the effects of ethanol on pups. Gestational effects of ethanol on the emission of USVs in rat pups have been studied in our previous research. In the present study, the effects of ethanol given to dams during lactation on the acoustic parameters of USVs emitted by isolated pups were examined. Ethanol was administered to dams from postnatal days (PNDs) 5–21. From PNDs 11–21, the high- and low-ethanol-treated dams were exposed to ethanol-containing water (v/v) at concentrations of 30% and 15%, respectively. Tap water without ethanol (0%) was provided to the control dams. The pups in all three ethanol-treated groups were separated from the dam and littermates on PNDs 4, 8, 12, and 16, and USVs produced by the pups were recorded for 5 min. It was found that elevated distress USVs with longer duration and higher percentage of frequency modulations were displayed by the pups from the high-ethanol dams. Alterations in USVs were particularly evident in the pups with a reduced body weight at PND 12. This effect might be because high-ethanol dams showed significantly lower intake of higher ethanol-containing water, and consequently, produced lower amount of milk, as well as exhibited poor maternal care. Insufficient maternal care and malnutrition resulted in pup growth retardation and increased mortality rate in the high-ethanol group, which were not observed in the low-ethanol or control pups. Accordingly, the pups in the high-ethanol group experienced elevated negative emotionality during isolation from their dam and increased emission of USVs. Longer duration and increased frequency modulation of pup USVs are expected to be noticed by the dam and to initiate/increase proper maternal care. It is concluded that ethanol given to lactating mothers has more serious consequences on pup development than the gestational ethanol exposure, and has more harmful effects on pups.
The Value of SSTR2 Receptor-Targeted PET/CT in Proton Irradiation of Grade I Meningioma
Authors: Pelak Maciej J. , Flechl Birgit , Mumot Marta , Galalae Razvan , Tubin Slavisa , Hug Eugen , Lütgendorf-Caucig Carola
Published: September 2021

Grade I meningioma is the most common intracranial tumor in adults. The standard imaging for its radiation treatment planning is MRI, and [68Ga]1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA)-conjugated PET/CT can further improve delineation. We investigated the impact of PET/CT on interobserver variability in identifying the tumor in 30 anonymized patients. Four radiation oncologists independently contoured residual tumor volume, first using only MRI and subsequently with the addition of PET/CT. Conformity indices (CIs) were calculated between common volumes, observer pairs and compared to the volumes previously used. Overall, 29/30 tumors (96.6%) showed [68Ga]Ga-DOTA avidity. With help of PET/CT, the participants identified six cases with new lesions not recognized in MRI, including two where new findings would critically alter the target volume used for radiation. The PET/CT-aided series demonstrated superior conformity, as compared to MRI-only between observer pairs (median CI = 0.58 vs. 0.49; p = 0.002), common volumes (CI = 0.34; vs. 0.29; p = 0.002) and matched better the reference volumes actually used for patient treatment (CI = 0.55 vs. 0.39; p = 0.008). Cis in the PET/CT-aided series were lower for meningiomas outside of the skull base (0.2 vs. 0.44; p = 0.03). We conclude that SSTR2 receptor-targeted PET/CT is a valuable tool for planning particle therapy of incompletely resected meningioma. It serves both as a workup procedure and an aid for delineation process that reduces the likelihood of marginal misses.
Whole-Brain Radiotherapy vs. Localized Radiotherapy after Resection of Brain Metastases in the Era of Targeted Therapy: A Retrospective Study
Authors: Koo Jaho , Roh Tae Hoon , Lee Sang Ryul , Heo Jaesung , Oh Young-Taek , Kim Se-Hyuk
Published: September 2021

Whether targeted therapy (TT) and radiotherapy impact survival after resection of brain metastases (BM) is unknown. The purpose of this study was to analyze the factors affecting overall survival (OS), local control (LC), distant control (DC), and leptomeningeal metastases (LMM) in patients who had undergone resection of BM. We retrospectively analyzed 124 consecutive patients who had undergone resection of BM between 2004 and 2020. Patient information about age, sex, Karnofsky Performance Scale (KPS), origin of cancer, synchronicity, tumor size, status of primary cancer, use of TT, extent of resection, and postoperative radiotherapy was collected. Radiation therapy was categorized into whole-brain radiotherapy (WBRT), localized radiotherapy (local brain radiotherapy or stereotactic radiosurgery (LBRT/SRS)), and no radiation. We identified factors that affect OS, LC, DC, and LMM. In multivariable analysis, significant factors for OS were higher KPS score (≥90) (HR 0.53, p = 0.011), use of TT (HR 0.43, p = 0.001), controlled primary disease (HR 0.63, p = 0.047), and single BM (HR 0.55, p = 0.016). Significant factors for LC were gross total resection (HR 0.29, p = 0.014) and origin of cancer (p = 0.041). Both WBRT and LBRT/SRS showed superior LC than no radiation (HR 0.32, p = 0.034 and HR 0.38, p = 0.018, respectively). Significant factors for DC were use of TT (HR 0.54, p = 0.022) and single BM (HR 0.47, p = 0.004). Reduced incidence of LMM was associated with use of TT (HR 0.42, p = 0.038), synchronicity (HR 0.25, p = 0.028), and controlled primary cancer (HR 0.44, p = 0.047). TT was associated with prolonged OS, improved DC, and reduced LMM in resected BM patients. WBRT and LBRT/SRS showed similar benefits on LC. Considering the extended survival of cancer patients and the long-term effect of WBRT on cognitive function, LBRT/SRS appears to be a good option after resection of BM.