bluuebunny/crossref_metadata_2025 huggingface dataset:
Examining “Salami slicing” publications as a side-effect of research performance evaluation: An empirical study
Authors: D’Angelo Ciriaco Andrea
Published: December 2024

Purpose

This study investigates whether publication-centric incentive systems, introduced through the National Scientific Accreditation (ASN: Abilitazione Scientifica Nazionale) for professorships in Italy in 2012, contribute to adopting “salami publishing” strategies among Italian academics.

Design/methodology/approach

A longitudinal bibliometric analysis was conducted on the publication records of over 25,000 Italian science professors to examine changes in publication output and the originality of their work following the implementation of the ASN.

Findings

The analysis revealed a significant increase in publication output after the ASN’s introduction, along with a concurrent decline in the originality of publications. However, no evidence was found linking these trends to increased salami slicing practices among the observed researchers.

Research limitations

Given the size of our observation field, we propose an innovative indirect approach based on the degree of originality of publications’ bibliographies. We know that bibliographic coupling cannot capture salami publications per se, but only topically-related records. On the other hand, controlling for the author’s specialization level in the period, we believe that a higher level of bibliographic coupling in his scientific output can signal a change in his strategy of disseminating the results of his research. The relatively low R-squared values in our models (0.3-0.4) reflect the complexity of the phenomenon under investigation, revealing the presence of unmeasured factors influencing the outcomes, and future research should explore additional variables or alternative models that might account for a greater proportion of the variability. Despite this limitation, the significant predictors identified in our analysis provide valuable insights into the key factors driving the observed outcomes.

Practical implications

The results of the study support those who argue that quantitative research assessment frameworks have had very positive effects and should not be dismissed, contrary to the claims of those evoking the occurrence of side effects that do not appear in the empirical analyses.

Originality/value

This study provides empirical evidence on the impact of the ASN on publication behaviors in a huge micro-level dataset, contributing to the broader discourse on the effects of quantitative research assessments on academic publishing practices.
First molecular characterisation of Sarcocystis miescheriana in a pig carcass condemned during routine meat inspection in Poland
Authors: Korpysa-Dzirba Weronika , Rubiola Selene , Bilska-Zając Ewa , Różycki Mirosław , Chiesa Francesco , Bełcik Aneta , Samorek-Pieróg Małgorzata , Kubacki Jakub , Łukomska Anna , Karamon Jacek , Sroka Jacek , Cencek Tomasz
Published: December 2024

Introduction

This article presents the fourth detection of macroscopic cystic lesions due to sarcocystosis in domestic pigs during routine meat inspection worldwide, and the first molecular detection of Sarcocystis miescheriana in a domestic pig in Poland. Pigs can become intermediate hosts for S. miescheriana by accidental ingestion of oocysts or sporocysts present in food or water contaminated by the faeces of canids (definitive hosts).

Material and Methods

The affected swine showed no clinical symptoms such as weight loss, dermatitis or dyspnoea suggesting sarcocystosis. The presence of grossly visible cyst-like lesions was noticed by veterinary inspectors during post-mortem meat inspection of pig carcasses at a slaughterhouse located in central Poland. Ten rice-grain-shaped white lesions were isolated from the muscle tissue for molecular analysis, and four other macroscopic cyst-like lesions were also isolated for histopathological and microscopy analysis. The molecular characterisation included amplification and sequencing of the cytochrome C oxidase subunit 1 mitochondrial gene.

Results

The cyst-like structures were whitish, calcified, 1 cm long and 3 mm wide. The presence of S. miescheriana DNA was confirmed in all ten grossly visible cyst-like lesions.

Conclusion

This study shows that Sarcocystis spp. may be present in swine muscle tissue and cause lesions leading to carcass discard. Further analyses are needed to fully recognise the prevalence and impact of Sarcocystis spp. on animal and human health, especially taking into account the possible presence of the zoonotic S. suihominis.
Motivational Climate, Satisfaction, and Intrinsic Motivation in University Students After the Application of a Gamified Intervention Using Traditional Sports Games
Authors: Gea-García Gemma María , Martínez Eduardo López
Published: December 2024

Gamified learning environments are widely used within the educational context in the subject of Physical Education. The aim of this study was to analyze the perception of the motivational climate, satisfaction, and intrinsic motivation of university students in practical classes according to gender and the type of methodology used. A total of 76 university students aged 20.58±1.69 participated in twelve two-hour practical sessions. The sessions were developed through traditional sport games, which were divided according to the type of methodology used: traditional (TRA, n=6) and gamified (GAM, n=6). Afterwards, to detect the differences in mean scores obtained for each of the methodologies used, the following tests, if needed, were performed: a non-parametric Friedman’s test with a post-hoc Wilcoxon test for pair-wise comparisons, or a two-factor repeated measures with a post-hoc Bonferroni test. Additionally, a Receiver Operating Characteristic curve analysis was performed to determine the cut-off point of the variables studied as a function of the classification of the study participants according to gender. The results showed differences in the perception of motivational climate according to gender in the traditional instructional approach. More specifically, the score for the dimension task climate was higher (M=4.21±0.58) than that recorded for the female students (M=4.57±0.45). In addition, for intrinsic motivation, the male students showed differences between both methodologies, with a higher score in the gamified program in the dimensions competence (M=3.63±0.51) effort-importance (M=3.57±0.55) and tension-pressure (M=2.92±0.85). Finally, there were significant differences between the two methodologies for satisfaction scores with the classes by gender. In each and every dimension that showed significant differences, the scores obtained by the female students were higher than those recorded for the male group in both methodologies. The application of a gamified intervention emerges as a powerful tool that could increase the motivation and satisfaction of students, favoring the teaching-learning process.
Ensino Profissional: Heranças do passado, constrangimentos do presente, desafios para o futuro
Authors: Traqueia Ana , Gonçalves Manuela , Madeira Rosa
Published: December 2024

Vocational Education, created in Portugal at the end of the 1980s, in the aftermath of the Revolution of the 25th of April 1974, still faces some constraints today, namely, the stigmatisation associated with unsuccessful school paths and the disadvantaged socioeconomic context of many students. However, the role of this education subsystem in the democratisation of access to Education and its contribution to social mobility, as well as to the construction of a fairer and more inclusive society in the light of Human Rights, stands out as envisioned by international guidelines and defended by the ideals of April. The article presents a narrative review of the literature, complemented by documentary analysis. It aims to contextualise Vocational Education in its historical, sociological and political-educational dimensions and critically reflect on issues related to its image and the processes of social exclusion and inclusion associated with it. Structured in past, present and future spaces, the text relates the received legacies to the faced constraints and the proposed challenges, considering that a historically and sociologically anchored approach leads to the problematisation of the associated phenomena. It is concluded that this is a complex and multidimensional field of analysis, requiring an inter and transdisciplinary discussion.
Public knowledge and practices regarding cutaneous leishmaniasis: a cross-sectional study
Authors: Alamro Sulaiman , Alsaqri Rayan , Aljulajil Abdulmalik , Alsaqri Lama , Alamro Alwaleed , Alawni Ziyad , Alharbi Lyan , Alharbi Abdullah
Published: December 2024

Objective: This study aimed to assess public knowledge and general practices related to cutaneous leishmaniasis (CL) in the Qassim region of Saudi Arabia.
Methods: A cross-sectional study was conducted from July to December 2024 among 400 adults in the Qassim region. Data were collected using a self-administered online survey, which included questions on demo graphics, knowledge of CL transmission, symptoms, high-risk groups, preventive measures, and management practices.
Results: Among the 400 participants, 54.3% (n = 217) had heard of CL, with family and friends being the most common information source (36.5%). However, knowledge gaps were evident where 40.3% (n = 161) correctly identified sandfly bites as the primary mode of transmission, while 43% (n = 172) could not identify common CL symptoms. Knowledge of preventive practices was also limited, with 41.3% being unsure of effective prevention strategies.
Conclusion: This study revealed substantial gaps in public knowledge and preventive practices regarding CL in the Qassim region. Targeted public health education initiatives are essential to improve awareness, promote preventive behaviors, and enhance community engagement in CL control efforts.
Comparative effectiveness of oral rehydration therapy versus intravenous therapy in pediatric gastroenteritis: a systematic review
Authors: Mobarki Ismail , Sumaily Yahya , Mobarki Majdi , Alwadani Mansour , Qussadi Abdullah , Majrabi Ahmed
Published: December 2024

Pediatric gastroenteritis, characterized by acute diarrheal illness, poses a significant global health challenge due to its potential to cause severe dehydration and electrolyte imbalance, especially in children under five years old. Effective management of dehydration is crucial, yet there is ongoing debate regarding the comparative effectiveness of oral rehydration therapy (ORT) versus intravenous (IV) therapy. This systematic review aimed to critically analyze and compare the effectiveness, safety, and clinical outcomes of ORT and IV therapy in the management of pediatric gastroenteritis. A comprehensive literature search was conducted across PubMed, Cochrane, ResearchGate, Cureus, and ScienceDirect databases, covering the period from the year 2004 to 2024. Studies were selected based on predefined inclusion and exclusion criteria. From an initial pool of 1,287 studies, 25 met the inclusion criteria and were included in this systematic review. The findings suggested that ORT was highly effective in managing mild to moderate dehydration in pediatric gastroenteritis, often reducing the need for hospitalization and associated costs. ORT with hypo-osmolar solutions was found to be superior in rehydration efficacy as compared to IV therapy in many cases. However, IV therapy was preferred in cases of severe dehydration or when ORT was contraindicated or failed. Balanced IV solutions, such as lactated Ringer's, showed better outcomes in terms of plasma bicarbonate levels and reduced risk of hypokalemia as compared to normal saline. The findings highlighted the need for widespread implementation of ORT protocols in clinical practice and suggested further research to refine treatment guidelines, particularly for severe dehydration scenarios.
Textos em Filosofia da Religião: Uma leitura clássica e contemporânea
Authors: Sipert Claudio , Oliveira Elialdo Rodrigues de , Leidens Francisco Rafael , Borges Marcos Alexandre , Dias Rafael Parente Ferreira
Published: December 2024

A presente publicação é uma coletânea de textos produzidos por professores e alunos da Pós-Graduação Lato Sensu em Filosofia da Religião, da Universidade Estadual de Roraima (UERR), fruto de suas pesquisas em torno do fenômeno religioso. Esta obra oferece uma jornada intelectual instigante, conduzindo o leitor por uma análise crítica e reflexiva, explorando as interseções entre filosofia e religião, tanto no contexto oriental quanto ocidental.
The Relationship Between Kinesiophobia, Physical Activity and Disability Level and Pain Management in Patients with Chronic Low Back Pain in Genders
Authors: Usta Nuri , Altuğ Filiz , Ünal Ayşe
Published: December 2024

Purpose: The aim of this study was to examine the relationship between pain management, kinesiophobia, physical activity and disability level in patients with chronic low back pain (CLBP) in different genders.
Methods: Eighty-two patients with CLBP (42 females, 42 males) between the ages of 20-60 participated in the study. Pain management strategies were determined by Pain Coping Questionnaire (PCQ). Tampa Scale for Kinesiophobia for perception of kinesiophobia, Oswestry Disability Index for disability due to pain and International Physical Activity Questionnaire-Short Form (IPAQ-SF) for the physical activity level were used.
Results: Women (mean age: 43.23±8.40 years) and men (mean age: 37.09±12.16 years) exhibited differences in helplessness (p=0.001) and conscious cognitive interventions (p=0.023) for pain management. No disparities were noted in self-coping and seeking medical help (p>0.05). Gender variation was significant in kinesiophobia (p=0.002), disability score (p=0.031), and disability percentage (p=0.018) among those with chronic low back pain. Notably, physical activity demonstrated gender balance (p>0.05), while sitting score had a significant difference (p=0.000). In both genders with CLBP, significant associations were found between PCQ dimensions and disability aspects, and in males, with physical activity (p
Targeting Vaccine Hesitancy A Data-Driven Approach Using AI and Public Health Data
Authors: Çetintav Bekir , Yalçın Ahmet
Published: December 2024

This study examines H1N1 and seasonal flu vaccination behaviors using machine learning models and explainable artificial intelligence (XAI) techniques. Utilizing data from the National 2009 H1N1 Influenza Survey, we developed a predictive framework employing models such as CatBoost, XGBoost, and LightGBM. CatBoost outperformed others with an accuracy of 0.696 and an F1 score of 0.688. SHAP (Shapley Additive Explanations) was used for interpretability, providing both global insights, such as the critical role of doctor recommendations, and local insights, highlighting individual decision factors. Our findings underscore the importance of addressing vaccine skepticism and improving healthcare communication to enhance vaccination uptake. These results contribute to public health strategies aimed at increasing immunization coverage and preparing for future pandemics.
La expansión de las narrativas transmedia en los videojuegos de las empresas de streaming. Los videojuegos en Netflix: Stranger Things 1984 y Narcos: Cartel Wars Unlimited
Authors: Galicia Martínez Ana Sixchel
Published: December 2024

El presente artículo se enfoca en el análisis de las narrativas transmedia a través de la plataforma de streaming Netflix. Desde el año 2021, esta empresa ha expandido sus contenidos más allá del video, como parte de sus estrategias mediáticas de comunicación, al incorporar videojuegos dentro de la suscripción mensual a su plataforma. Estos juegos tienen el valor agregado de pertenecer a las narrativas originales de los contenidos, no contener comerciales, ni pagos extra dentro de la aplicación.
Por ello, se examinan las similitudes y diferencias entre dos series y sus respectivos videojuegos: Stranger Things y Narcos, junto con Stranger Things 1984 y Narcos: Cartel Wars Unlimited. Ambas series han marcado significativamente el despliegue de las narrativas en otros medios.
Mediante un enfoque narrativo-hermenéutico, se exploran las categorías de personajes, espacios, tiempo, estilo narrativo, participación de la audiencia y estructura narrativa en los contenidos mencionados. Esto permite investigar las estrategias y formas en las que se configuran las narrativas transmedia para mantener la coherencia y participación de los usuarios.
La dieta mediática del futuro profesorado de educación secundaria en España: consumo, confianza en los medios, polarización, locus de control y autopercepción del nivel informacional
Authors: López-González Hibai , Sabido-Codina Judit , Franganillo Jorge , Hurtado Daniel , Barriga-Ubed Elvira
Published: December 2024

La educación mediática es un eje esencial en la formación de una ciudadanía crítica e informada. Por tanto, parece razonable argumentar que el nivel de educación mediática de las futuras generaciones dependerá, en parte, de la formación que sus educadores tengan en dicho ámbito. Para entender mejor esa relación, este estudio analiza la dieta mediática consumida, la confianza en los medios, la polarización mediática, el locus de control y la autopercepción del nivel informacional que señala tener el alumnado matriculado en el máster en formación del profesorado en diferentes comunidades autónomas de España. Los futuros docentes de la muestra (N = 716) completaron el cuestionario diseñado mediante sus dispositivos móviles, a través de la plataforma Qualtrics. Los resultados manifiestan que los participantes se consideran capacitados para analizar críticamente los aspectos formales de las noticias para el cuestionamiento de su veracidad, así como que está en su mano evitar ser víctimas de la desinformación. Sobre la polarización mediática, por regla general, la mayoría de los encuestados indica consumir contenido informacional con puntos de vista diferentes a los propios.
René Descartes: individuo, sociedad, política
Authors: Llinàs Begon Joan Lluís
Published: December 2024

La cuestión que se quiere resolver en este artículo es si, pese a que la política queda fuera del sistema filosófico que plantea Descartes, hay espacio aún para ella en la reflexión filosófica derivada de dicho sistema. Para ello, se analizarán los siguientes textos cartesianos: la carta-prefacio de la edición francesa de Los principios de la filosofía, con el fin de aclarar la estructuración y la finalidad del sistema; Las pasiones del alma, para elucidar en qué consiste la moral que ocupa el lugar más alto en el árbol de la filosofía, y plantear en consecuencia la dimensión social de la moral; la correspondencia con Elisabeth de Bohemia permitirá analizar la posición de Descartes hacia la política. La conclusión pasa por considerar una doble dimensión del fenómeno político, una ligada a la vida social y otra a la estructuración del poder político y a las acciones de los gobernantes.
Deseo y amor en Descartes
Authors: Rivero Yelitza
Published: December 2024

En el presente trabajo expongo la noción de pasión en la filosofía cartesiana y su estrecha e ineludible relación con el cuerpo. Considero que Descartes en su tratamiento de las pasiones destaca el papel que juega nuestro cuerpo para establecer relaciones con las cosas del mundo y con los otros individuos. En este sentido, las pasiones sirven para indicar al individuo la conveniencia o no del mundo exterior con la intención de conservar su existencia, información que no puede ser obtenida por la sola capacidad racional. Por otra parte, las pasiones nos ofrecen ciertas maneras de relacionarnos con los otros individuos, que pueden darse a través del amor y el deseo.
De razones y pasiones en René Descartes
Authors: Monroy Nasr Zuraya
Published: December 2024

Para exponer lo que Descartes dijo acerca de la razón y de las pasiones, hay que comprender sus razones para dar a la mente el lugar privilegiado que le otorga en su filosofía. Por una parte, Descartes defendió su dualismo, sin hacer concesiones acerca de la naturaleza incorpórea de la mente, debido a las exigencias de su proyecto científico-filosófico. Por otra parte, en la obra cartesiana aparece la concepción de la unión del cuerpo y la mente de los seres humanos, así como de su entremezcla. La presencia del dualismo y la unión en la obra de Descartes ha generado interpretaciones diversas. Para una mejor comprensión de la concepción cartesiana al respecto, los reconsidero bajo una perspectiva opuesta a quienes consideran contradictoria la propuesta de Descartes. Esta perspectiva permite reconocer los aspectos antropológicos (morales, psicológicos, sociales) del pensamiento cartesiano y ver que también fue un pensador acerca de las pasiones.
Substância, natureza e “unidade de composição” em Descartes
Authors: De Almeida Campos Mariana
Published: December 2024

Na primeira parte do artigo, eu vou examinar algumas definições de substância que Descartes oferece em sua obra com o objetivo de discutir a questão sobre se os humanos são substâncias. Também estará no horizonte dessa discussão a questão sobre se os corpos particulares e, como consequência, os animais, são substâncias ou modos de uma única substância corpórea. Na segunda parte do artigo, eu vou examinar o conceito de natureza e na terceira e última parte examinarei o conceito de “unidade de composição”. A tese que eu pretendo sustentar é a de que embora, em Descartes, os humanos e os animais formem “unidades de composição”, e, além disso, sejam dotados de naturezas particulares, livremente estabelecidas por Deus, eles não podem ser considerados substâncias cartesianas.
Descartes : l’invention du moi moderne ?
Authors: Kambouchner Denis
Published: December 2024

Je souhaiterais revenir sur une représentation qui nous est à tous familière : celle d’après laquelle, au vrai départ de la modernité, l’on trouverait l’œuvre de Descartes, et plus précisément, dans cette œuvre, la constitution, l’activité et la mise en scène d’un moi. Ce mot lui-même, « la modernité », désignerait en somme un nouvel âge de la subjectivité, un âge de la subjectivité proprement dite, et cette subjectivité serait, par excellence, la subjectivité cartésienne.
Neutralizing the negative impact of digital devices and the Internet on children under 11: a sociological approach
Authors: Buchkova Alla Ivanovna
Published: December 2024

The work is devoted to the problem of excessive impact of digital devices and the Internet on the younger generation. The subject of the study was digital consumption by children before adolescence. The author examines in detail such aspects of the topic as the peculiarities of introducing children to digital devices and the Internet, the positive and negative consequences of digital socialization, the forms of content preferred by children, the socializing functions and culture of digital consumption of children, as well as the role of adults in the process of forming the latter. It is noted that early introduction to digital devices has become an obligatory part of modern upbringing of children. The main attention is paid to the harmonization of digital socialization of the younger generation in the context of rapid development of technologies and information flows. The author conducted a sociological analysis of digital consumption by children under 11 years of age. The paper presents the results of a survey of 207 families from Moscow and the Moscow region in 2023, as well as an expert survey of 12 experts in the field of child rearing, preschool and primary school education in 2024. The study revealed that children are introduced to digital devices starting from the age of one and a half to two years. Negative consequences include health and developmental disorders, while positive impact is associated with increased competitiveness and development of cognitive skills of the child. The novelty of the study lies in the fact that the author offers specific recommendations for harmonizing digital consumption. A conclusion is made about the need to form a culture of digital consumption from an early age, as well as the role of parents and teachers as mediators in the process of digital socialization.
International legal aspects of the Black Sea Grain Initiative
Authors: Gordeev Artem
Published: December 2024

The subject of the study is the international agreements concluded within the framework of the Black Sea Grain Initiative as one of the humanitarian vectors of cooperation between states in the field of agriculture and food security under restrictive measures, as well as other international legal and non-legal acts. The object of the study is international interstate relations developing in the process of cooperation in the field of agriculture, food security, humanitarian cooperation, as well as interstate cooperation in the field of the use of the high seas and territorial waters. The purpose of the study was to analyze the international legal characteristics of the agreements concluded within the framework of the Black Sea Grain Initiative (BSGI), including determining the main prerequisites for their conclusion and identifying their significance for international law. In the course of the research, such methods of scientific cognition were used as: dialectical, method of analysis and synthesis, deduction and induction, statistical, system-structural, historical, formal legal, comparative legal, method of legal linguistics. The novelty of the study is determined by the fact that there is no research in the domestic doctrine devoted to the international legal characteristics of BSGI. As a result of the study, it was revealed that the main factors contributing to the BSGI were the negative impact of unilateral restrictive measures against the Russian Federation on the one hand and the armed conflict in Ukraine on the other hand. At the same time, unilateral restrictive measures against the Russian Federation affecting the domestic agricultural sector, by their legal nature, contradict the basic principles of international law. The international agreements within the framework of the BSGI had a humanitarian purpose and were mainly aimed at stabilizing global food security. The Memorandum and the Initiative concluded within the framework of the BSGI have different legal status and are not formally interrelated: The Initiative concluded by the Russian Federation, Turkey and Ukraine is an international treaty, whereas the Memorandum between the UN Secretariat and the Russian Federation is a non-legal agreement. The main importance of the BSGI for international law is as follows: states are able to cooperate with each other in order to ensure food security even in conditions of geopolitical tension; Russia is ready to faithfully fulfill its international legal obligations; it is necessary to further develop the UN mediation function in resolving issues related to ensuring global food security.
Can Criminal Defense Attorneys Be Victim-Centered?
Authors: Nanasi Natalie , Lopez-Loftis Demetrice
Published: December 2024

Attorneys defending those accused of intimate partner violence, like all lawyers, owe duties of zealous advocacy and confidentiality to their clients. But is there a place within these ethical obligations for them to also consider the safety of the victim? Defense counsel are often uniquely situated—by virtue of their relationships with their clients and victims—to help mitigate potentially serious harm. This article explores the spaces where defending an accused perpetrator of domestic violence and taking actions to limit further harm to a survivor are compatible. It also identifies areas where defense attorneys can obtain additional resources and data to inform their decision-making when considering lawful exceptions to the ethical requirements of zealous advocacy and confidentiality. Lastly, it considers policy proposals, such as providing attorneys for survivors in the criminal process and revisions to the ethics rules, to address potential areas of conflict.
The Clinical Diagnosis and Treatment of an Anterior Calcaneal Process Fracture Overlooked on Imaging: A Case Study
Authors: Gilbert-Hogan, Teri
Published: December 2024

BACKGROUND: Anterior calcaneal process fractures are often overlooked on radiographs. Given a similar clinical presentation, these fractures are frequently misdiagnosed as lateral ankle sprains.

CASE DESCRIPTION: A 43-year-old male was referred to physical therapy following an inversion ankle injury. Sites of interest identified on initial radiography were asymptomatic, including an os trigonum and possible dorsal talar avulsion fracture. Screening with the Ottawa ankle rules was negative. His clinical presentation was similar to an inversion ankle sprain with concordant swelling and pain.

OUTCOME: Subsequent ankle imaging was completed following a lack of expected clinical progression, revealing a subtle calcaneal fracture overlooked on initial imaging. The patient was referred to orthopedics and managed in a boot with partial weight-bearing. He was released to full weight-bearing 6 weeks later with resolution of pain and gradual recovery of normalized range of motion and strength.

DISCUSSION: Improving proficiency of interpreting radiograph images as physical therapists, application of the four-eyes principle when reading images, and awareness of potential fractures with negative Ottawa ankle rules screening are beneficial to early and accurate diagnosis and treatment of foot fractures. JOSPT Cases 2025;5(1):12-17. Epub 20 December 2024. doi:10.2519/josptcases.2024.0086
Síndrome de Quebra-Nozes e o tratamento de angioplastia com stent
Authors: Leme Millena Travessini , Safanelli Ana Paula , Lauxen Nicolas Cardoso , Pinto Andressa Ribeiro , Stradiotto Gabriela Baggenstoss , Nemer Mariana Eduarda , Silva Samuel Victor de Arruda e , Plugge Felipe Fridlund , Silva Sofia Joaquim Pimenta da , Pilatti Murilo
Published: December 2024

Objetivo: Apresentar o favorável desfecho clínico de uma paciente portadora da Síndrome de Quebra-Nozes, utilizando-se da técnica de angioplastia com stent como forma promissora de tratamento. Detalhamento do caso: Trata-se de uma paciente de 47 anos, diagnosticada com a Síndrome de Quebra-Nozes, com queixa de dor pélvica crônica desde a sua adolescência, dor no flanco esquerdo e episódios de hematúria. Realizou ultrassonografia transvaginal e de abdome total, que evidenciou varizes pélvicas, dilatação das veias gonadais e estenose significativa da veia renal esquerda. Foi submetida à angioplastia com Stent XL 16x40 da veia renal e à embolização das varizes pélvicas associadas. A paciente evoluiu sem intercorrências e recebeu alta hospitalar com prescrição de ácido acetilsalicílico. Considerações finais: A Síndrome do Quebra-Nozes manifesta-se clinicamente pela compressão e consequente estenose da veia renal esquerda pela artéria mesentérica superior e/ou pela artéria aorta, havendo diversos tratamentos que vão desde uma abordagem conservadora e cirurgia abertas até métodos endovasculares. Com o desenvolvimento de novas tecnologias, o tratamento endovascular tornou-se uma opção menos invasiva quando em comparação às cirurgias abertas devido ao seu menor caráter invasivo e iatrogênico, de modo a possuir risco reduzido de morbidades e complicações ao paciente.
O impacto do jejum na estimulação de células NK para o combate ao câncer
Authors: Ancines Fernanda  Vargas , Paim Ana Carolina da Costa , Dias Bruna Bernardes , Tonin Diane Gabrieli , Damian Francine Bester , Rozin Isadora Piva , Fabonato Luiza Barcelos , Wentz Luiza Kettenhuber , Fontana William Augusto , Alves Gabriel Cabeda Spalding
Published: December 2024

Objetivo: Elucidar o impacto do jejum na estimulação de células NK no combate ao câncer. Revisão bibliográfica: As células Natural Killer (NK) desempenham um papel crucial na imunidade inata, especialmente na eliminação de células tumorais. Nesse sentido, o jejum e dietas que mimetizam o jejum (FMDs) podem intensificar a atividade dessas células, promovendo um microambiente menos favorável ao crescimento de tumores. Ao modular a resposta imunológica, essas práticas reduzem estímulos que favorecem o desenvolvimento do câncer e, ao mesmo tempo, podem minimizar os efeitos adversos comuns de tratamentos oncológicos, como a quimioterapia. Dessa forma, a integração entre estratégias nutricionais e imunológicas aponta o jejum como um potencial coadjuvante em terapias anticâncer, ressaltando a necessidade de adaptações personalizadas para garantir tanto a segurança quanto a maximização dos benefícios do tratamento. Considerações finais: Embora o jejum ofereça benefícios no combate ao câncer, como o fortalecimento da resposta das células NK, é essencial avaliar cuidadosamente os riscos e adequar os protocolos de jejum, especialmente para pacientes oncológicos avançados, garantindo um acompanhamento personalizado para maximizar os efeitos terapêuticos e minimizar possíveis complicações.
N-acetyltransferase 10 regulates UNC-51-like kinase 1 to reduce tubular cell injury and kidney stone formation
Authors: Wang Le , Huang Jinjing , Song Lei , Ke Ben
Published: December 2024

Objective:

Among the most common chronic kidney diseases, kidney stones are second only to hypertension. Kidney stones pose a public health threat due to their increased incidence, high recurrence rate, and heavy economic burden. In this work, we investigated the potential mechanism of N-acetyltransferase 10 (NAT10) in oxidative stress and pyroptosis of renal tubular epithelial cells (RTECs).

Material and Methods:

A kidney-stone cell model was simulated using calcium oxalate monohydrate (COM) in vitro. Western blot analysis of NAT10 expression and N4-acetylcytidine RNA immunoprecipitation verified the regulatory efficacy of NAT10 in Unc-51 like autophagy activating kinase 1 (ULK1) ac4C modification. The luciferase reporter gene assay further verified the interaction between NAT10 and ULK1. A kidney stone model was established using BALB/c mice injected with glyoxylic acid.

Results:

COM can dose-dependently suppressed the cell viability and superoxide dismutase activity of HK-2 cells and promoted the release of lactate dehydrogenase and malondialdehyde levels (P < 0.05). COM also promoted apoptosis in HK-2 cells, upregulated the protein levels of caspase-1 and gasdermin D-N, and simultaneously enhanced the HK-2 cell secretion of interleukin-1b (IL-1b) and IL-18 (P < 0.05). The overexpression of NAT10 in HK-2 cells reversed the aforementioned effects, and that of NAT10 upregulated the messenger RNA (mRNA) levels of ULK1 and increased ac4C modification (P < 0.01). Furthermore, only the luciferase activity of the wild-type ULK1 containing NAT10 binding sites was enhanced with the upregulation of NAT10 (P < 0.001). Actinomycin D treatment showed that NAT10 overexpression extended the half-life of ULK1 mRNA (P < 0.01). Silencing of ULK1 neutralized the effects of NAT10 overexpression on COM-induced cell injury (P < 0.05). In addition, the increased expression of NAT10 inhibited crystal deposition, oxidative stress, and apoptosis in vivo (P < 0.05).

Conclusion:

This study confirmed that NAT10 inhibits RTECs oxidative stress and cell pyrodeath through the enhanced ac4C modification of ULK1 and impedes kidney stone progression.
Efficacy of radiosurgery with and without angioembolization: A subgroup analysis of effectiveness in ruptured versus unruptured arteriovenous malformations – An updated systematic review and meta-analysis
Authors: Khan Hamza , Sangah Abdul Basit , Nasir Roua , Khan Saad Akhtar , Shaikh Shazia Saleem , Ahmed Ikhlas , Abbasi Mohad Kamran , Ahmed Asma , Siddiqui Dua , Hussain Syeda Ayesha , Akhunzada Naveed Zaman , Godfrey Oswin
Published: December 2024

Background:

Congenital arterial defects such as cerebral arteriovenous malformations (AVMs) increase brain bleeding risk. Conservative therapy, microsurgical removal, percutaneous embolization, stereotactic radiosurgery (SRS), or a combination may treat this serious disease. This study compares angioembolization with SRS to SRS alone in ruptured or unruptured brain ateriovenous malformations (BAVM) patients.

Methods:

We followed Preferred Reporting Items for Systematic Reviews and Meta-Analyses recommendations for this study. Until September 2023, PubMed/Medline, Cochrane, and Clinicaltrials.gov were searched for literature. English-language studies comparing SRS alone to embolization with SRS on ruptured or non-ruptured AVMs that could not be operated on were considered. The Newcastle–Ottawa Scale assessed research study quality.

Results:

Results included 46 studies with a total of 7077 participants. There was a greater obliteration rate in the SRS-only group (60.4%) than in the embolization plus SRS group (49.73%). Particularly in the SRS-only group, ruptured AVMs showed a noticeably greater obliteration rate than unruptured AVMs (P = 0.002). However, no notable differences were found in hemorrhagic events or radiation-induced changes between the two groups; however, the SRS-only group had a slightly greater, yet not statistically significant, mortality rate.

Conclusion:

Our data showed that ruptured brain AVMs had a much greater obliteration rate than unruptured ones, mostly due to SRS alone, without embolization. The aggregated data showed no significant changes, whereas SRS alone decreased radiation-induced alterations and hemorrhagic rates but with increased mortality. SRS alone may have a higher risk-to-reward ratio for nidus obliteration in ruptured brain AVM patients, so it should be used without embolization, although more research is needed to determine the effects of immediate and late complications.
Bilateral hypothalamotomy plus dominant amygdalotomy with Gamma Knife radiosurgery. A non-invasive alternative when everything has failed in the management of aggressive behavior disorder
Authors: Romero Oscar I. Molina , Diez-Palma Juan Carlos , Fonnegra-Caballero Andrés , Segura-Hernández Andrés , Matinez-Alvarez Roberto , Yamhure Edgar , Camargo Julian Felipe , Fonnegra-Pardo Julio Roberto
Published: December 2024

Background:

Impulsive aggression is the core symptom of intermittent explosive disorder, which can be a feature of several psychiatric disorders. There is a subset of individuals who do not respond adequately to medical treatment; they are treatment refractory. The objective of this report is to describe a case of a patient with a background of schizophrenia and concomitant refractory aggressiveness disorder, treated with two-stage bilateral hypothalamotomy and unilateral amygdalotomy with Gamma Knife radiosurgery (GKR).

Case Description:

A 36-year-old male presented with a background of paranoid schizophrenia. Episodes of self- and hetero-aggressiveness were present at the initial diagnosis. High dosages of psychotropic medication were taken, and 70 sessions of electroconvulsive therapy were performed; however, no adequate response was obtained. Bilateral hypothalamotomy plus left amygdalotomy through GKR was performed. After 25 months of follow-up, a marked decrease in the frequency, degree, severity of aggressiveness and the requirement for psychotropic medications was observed.

Conclusion:

Hypothalamotomy plus amygdalotomy with Gamma Knife may be an effective ablative technique for the management of refractory aggressive disorder in patients with mental illness.
A comparative meta-analysis of mini-transverse versus longitudinal techniques in the treatment of carpal tunnel syndrome
Authors: Aleid Abdulsalam Mohammed , Alanazi Sultan Nawaf , Aljabr Abdulmajeed Abdulaziz , Almalki Sami Fadhel , AlAidarous Hasan Ali Abdullah , Alzahrani Abdulwahab Ahmed , Aleid Zainab Mohammed , Alghamdi Yousef Khalaf A. , Aldanyowi Saud Nayef
Published: December 2024

Background:

Carpal tunnel syndrome (CTS) is a common nerve entrapment condition, and there is ongoing debate regarding the superiority of traditional open versus minimally invasive carpal tunnel surgery.

Methods:

This meta-analysis reviewed six studies involving 478 patients to compare recovery and functional outcomes between the traditional longitudinal technique and the minimally invasive mini-transverse technique. The primary outcomes included the functional status scale (FSS), symptoms severity scale (SSS), pain scores, time to return to work, duration of operation, and incidence of complications.

Results:

The mini-transverse technique was associated with lower FSS and SSS scores compared to the longitudinal technique, with mean differences (MD) of −0.32 (95% confidence level [CI]: −0.52, −0.12, P = 0.002) and −0.43 (95%CI: −0.6, −0.25, P < 0.00001), respectively. Pain scores were also lower with the mini-transverse technique (MD) of −0.5 (95%:CI: −0.71, −0.3, P < 0.00001). The mini-transverse group had a statistically significant shorter time to return to work (MD) of −8.34 (95%CI: −13.55, −3.13, P = 0.002). No significant differences were found in the duration of surgery (MD) of −6.96 (95%CI: −16.66, 2.74, P = 0.16) or incidence of complications (MD) of 0.46 (95%CI: 0.15, 1.4, P = 0.17).

Conclusion:

The mini-transverse approach for CTS resulted in better outcomes, including less pain, faster recovery, and improved hand function. There was no significant difference in surgery time or complications compared to the traditional technique, suggesting it may be the preferable option.
Implementasi Permainan Busy Jar Untuk Melatih Kognitif dan Motorik Pada Anak Usia Dini di TK Lumbung Sari
Authors: Suciari Putri Ida Ayu Eka , Gede Anadhi I Made , Sindu Putra Ida Bagus Komang , Suardika I Komang
Published: December 2024

This study is motivated by the cognitive abilities of TK Lumbung Sari children are still lacking in learning activities, so to help children develop their cognitive abilities, a medium is needed that is used in the learning process such as busy jar. Busy jar is a tube-shaped media from plastic material which in the bottle cap there are holes of various shapes such as geometric shapes. This study aims to train cognitive in early childhood. The purpose of this study is to train early childhood self-confidence and to teach children geometric shapes, train children's fine motor skills and increase children's vocabulary in mentioning geometric shapes and colors. This study uses qualitative research methods, data collection techniques used in this study are observation and interviews. The subjects in this study were 23 students at TK Lumbung Sari. This study uses observation and interviews in collecting data.  This study shows the results where when playing busy jar students are very happy to carry out this busy jar play activity but there are some students when playing this game at the Pre-test stage there are those whose abilities have not developed, so the researcher sees the child's development at the next stage, namely the post-test stage and from the results of this simulation stage the student's ability has begun to develop so that the results of this busy jar game can be concluded that busy jar games are suitable for cognitive and motor training in children and have a positive impact received by early childhood.
Законодательный стиль Гражданского кодекса РФ: вопросы преемственности и динамики
Authors: Давыдова М.Л.
Published: December 2024

Статья подготовлена в рамках научной полемики, инициированной публикациями профессора А.Я. Рыженкова, как ответ на его идею о влиянии фундаментальных процессов, связанных с динамикой метода гражданского права, на технику изложения статей Гражданского кодекса РФ, в частности, на возрастание неопределенности в установлении прав и обязанностей. Включение данной проблемы в общий контекст тенденций, характерных для юридической техники российского законодательства, позволяет увидеть ее иначе. Отсутствие стабильности и множественные изменения законов, усложнение нормативного текста, повышение казуистичности правовых велений, канцеляризация, бюрократизация юридического языка характерны для всех нормативных правовых актов. В статье проводится мысль о том, что на фоне других нормативных правовых актов Гражданский кодекс РФ сохраняет неплохие позиции по уровню читабельности текста. Во многом это обусловлено наличием собственного законодательного стиля, поддерживаемого мощной доктринальной традицией. Этот стиль делает текст кодекса узнаваемым, обеспечивает преемственность в способах изложения правовых предписаний, побуждая все вносимые в него корректировки аккуратнее встраивать в основной текст. Повышение неопределенности (как общая тенденция в развитии законодательства, и не только гражданского), действительно, имеет место, но, скорее, не как результат использования каких-то новых приемов юридической техники, а как следствие низкой языковой культуры законодателя.

The article was prepared as part of the scientific controversy initiated by the publications of Professor A.Ya. Ryzhenkov as a response to his idea of the influence of fundamental processes associated with the dynamics of the civil law method on the legal technique of the civil code, in particular, on the increase in the uncertainty of legal norms. The inclusion of this problem in the general context of the trends in modern legal technique of Russian legislation allows us to see it differently. The lack of stability and multiple changes in laws, the complication of the regulatory text, the increase in the casuistry of legal decrees, the clericalization, bureaucratization of the legal language are characteristic of all legal acts. The article suggests that, against the background of other legal acts, the civil code retains a good position in terms of the level of readability of the text. This is largely due to the presence of its own legislative style, supported by a powerful doctrinal tradition. This style makes the text of the civil code recognizable, ensures continuity in the ways of presenting legal prescriptions, prompting all corrections made to it to be more accurately integrated into the main text. Increasing uncertainty (as a general trend in the development of legislation - and not only civil) does indeed take place, but rather not as a result of some new methods of legal technique, but as a result of the low linguistic culture of the legislator.