bluuebunny/crossref_metadata_2025 huggingface dataset:
Chinese Event Extraction Based on Attention and Semantic Features: A Bidirectional Circular Neural Network
Authors: Wu Yue , Zhang Junyi
Published: September 2018

Chinese event extraction uses word embedding to capture similarity, but suffers when handling previously unseen or rare words. From the test, we know that characters may provide some information that we cannot obtain in words, so we propose a novel architecture for combining word representations: character–word embedding based on attention and semantic features. By using an attention mechanism, our method is able to dynamically decide how much information to use from word or character level embedding. With the semantic feature, we can obtain some more information about a word from the sentence. We evaluate different methods on the CEC Corpus, and this method is found to improve performance.
A Time-Efficient Dip Coating Technique for the Deposition of Microgels onto the Optical Fiber Tip
Authors: Scherino Lorenzo , Giaquinto Martino , Micco Alberto , Aliberti Anna , Bobeico Eugenia , La Ferrara Vera , Ruvo Menotti , Ricciardi Armando , Cusano Andrea
Published: September 2018

The combination of responsive microgels and Lab-on-Fiber devices represents a valuable technological tool for developing advanced optrodes, especially useful for biomedical applications. Recently, we have reported on a fabrication method, based on the dip coating technique, for creating a microgels monolayer in a controlled fashion onto the fiber tip. In the wake of these results, with a view towards industrial applications, here we carefully analyze, by means of both morphological and optical characterizations, the effect of each fabrication step (fiber dipping, rinsing, and drying) on the microgels film properties. Interestingly, we demonstrate that it is possible to significantly reduce the duration (from 960 min to 31 min) and the complexity of the fabrication procedure, without compromising the quality of the microgels film at all. Repeatability studies are carried out to confirm the validity of the optimized deposition procedure. Moreover, the new procedure is successfully applied to different kinds of substrates (patterned gold and bare optical fiber glass), demonstrating the generality of our findings. Overall, the results presented in this work offer the possibility to improve of a factor ~30 the fabrication throughput of microgels-assisted optical fiber probes, thus enabling their possible exploitation in industrial applications.
Assessing the Impact of Climate Variability on Wildfires in the N’Zi River Watershed in Central Côte d’Ivoire
Authors: Kouassi Jean-Luc Kouakou , Wandan Narcisse Eboua , Mbow Cheikh
Published: September 2018

This study evaluates the impact of climate variability on wildfire regime in the N’Zi River Watershed (NRW) in central Côte d’Ivoire. For that purpose, MODIS active fire and monthly burned area data are used to evaluate wildfire occurrence, impacts and trends. Wildfire data are compared to past trends of different climatic parameters extracted from long-term meteorological records. Generalized additive models and Spearman correlations are used to evaluate the relationships between climate variables and wildfire occurrence. Seasonal Kendall and Sen’s slope methods were used for trend analysis. Results showed that from 2001 to 2016, 19,156 wildfire occurrences are recorded in the NRW, of which 4443 wildfire events are observed in forest, 9536 in pre-forest, and 5177 in Sudanian zones. The burned areas are evaluated at 71,979.7 km2, of which 10,488.41 km2 were registered in forest, 33,211.96 km2 in pre-forest, and 28,279.33 km2 in Sudanian zones. A downward trend is observed in fire records. The results indicates a strong correlation between some climatic variables and wildfire regime in this ecoregion. These correlations can be used to develop models that could be used as prediction tools for better management of fire regimes and support decision-making in the NRW.
Intentions-Based Reciprocity to Monetary and Non-Monetary Gifts
Authors: Chao Matthew
Published: September 2018

Social preference models emphasize that perceived intentions motivate reciprocity. However, laboratory tests of this theory typically manipulate perceived intentions through changes in wealth resulting from a sacrifice in pay by another. There is little evidence on whether reciprocity occurs in response to perceived intentions alone, independent of concurrent changes in pay and giver sacrifice (and any associated guilt from that sacrifice). This paper addresses this gap in the literature by implementing a modified dictator game where gifts to dictators are possible, but where gift transactions are also stochastically prevented by nature. This leads to instances of observed gift-giving intentions that yield no sacrifice or change in outcomes. In addition, this study uses both monetary and non-monetary gifts; previous studies typically use only monetary incentives, even though real-world applications of this literature often involve non-monetary incentives such as business or marketing gifts. The results show that on average, dictators reciprocated strongly to just the intention to give a gift, and they also reciprocated similarly to both monetary and non-monetary gifts. These results are consistent with intentions-based models of social preferences and with much of the marketing literature on business gifts.
Effects of Different Sulfur Dioxide Pads on Botrytis Mold in ‘Italia’ Table Grapes under Cold Storage
Authors: Ahmed Saeed , Roberto Sergio Ruffo , Domingues Allan Ricardo , Shahab Muhammad , Junior Osmar José Chaves , Sumida Ciro Hideki , De Souza Reginaldo Teodoro
Published: September 2018

‘Italia’ grape is one of the most important table grape cultivars grown worldwide. Gray mold, caused by Botrytis cinerea Pers. Fr., is one of the most important causes of postharvest decay of table grapes, and the control of this disease is very difficult because postharvest treatments with synthetic fungicides are not allowed in many countries. The objective of this study was to compare different types of pads releasing different doses of SO2 during cold storage to control gray mold in ‘Italia’ table grapes grown under subtropical conditions. Grape bunches were harvested from a commercial field trained on an overhead trellis located at Cambira, state of Parana (PR), South Brazil. The grapes were packed into carton boxes (capacity, 4.5 kg) and subjected to the following SO2 pad treatments (Uvasys®, Cape Town, South Africa) under cold storage (1.0 ± 1 °C) for 50 days: (i) Control; (ii) SO2 slow release pad; (iii) SO2 dual release pad; (iv) SO2 dual release–fast reduced pad; (v) SO2 slow release pad with grapes inoculated with B. cinerea suspension; (vi) SO2 dual release pad with grapes inoculated with B. cinerea suspension; and (vii) SO2 dual release-fast reduced pad with grapes inoculated with B. cinerea suspension. After cold storage, the grape boxes were maintained for 7 days at room temperature (25 °C). The incidence of gray mold on the grapes, firmness, shattered berries, stem browning, as well as other physicochemical variables, such as bunch mass, bunch mass loss, skin color, soluble solids (SS), titratable acidity (TA) and SS/TA were evaluated. Both SO2 dual release pads were highly efficient in preventing the incidence of gray mold in ‘Italia’ grapes packed in clamshells during the 50-day period of cold storage and at room temperature, even with Botrytis-inoculated berries. The SO2 slow release pad showed lower efficiency, but was higher than the control. The SO2 dual release pad treatments provided the best results with respect to stem browning scores (fresh and green stems) during cold storage, and no differences were observed among the treatments with respect to the other physicochemical evaluations.
Short-Term Water Demand Forecasting Model Combining Variational Mode Decomposition and Extreme Learning Machine
Authors: Seo Youngmin , Kwon Soonmyeong , Choi Yunyoung
Published: September 2018

Accurate water demand forecasting is essential to operate urban water supply facilities efficiently and ensure water demands for urban residents. This study proposes an extreme learning machine (ELM) coupled with variational mode decomposition (VMD) for short-term water demand forecasting in six cities (Anseong-si, Hwaseong-si, Pyeongtaek-si, Osan-si, Suwon-si, and Yongin-si), South Korea. The performance of VMD-ELM model is investigated based on performance indices and graphical analysis and compared with that of artificial neural network (ANN), ELM, and VMD-ANN models. VMD is employed for multi-scale time series decomposition and ANN and ELM models are used for sub-time series forecasting. As a result, ELM model outperforms ANN model. VMD-ANN and VMD-ELM models outperform ANN and ELM models, and the VMD-ELM model produces the best performance among all the models. The results obtained from this study reveal that the coupling of VMD and ELM can be an effective forecasting tool for short-term water demands with strong nonlinearity and non-stationarity and contribute to operating urban water supply facilities efficiently.
Analysis of Gut Microbiota in Rheumatoid Arthritis Patients: Disease-Related Dysbiosis and Modifications Induced by Etanercept
Authors: Picchianti-Diamanti Andrea , Panebianco Concetta , Salemi Simonetta , Sorgi Maria Laura , Di Rosa Roberta , Tropea Alessandro , Sgrulletti Mayla , Salerno Gerardo , Terracciano Fulvia , D’Amelio Raffaele , Laganà Bruno , Pazienza Valerio
Published: September 2018

A certain number of studies were carried out to address the question of how dysbiosis could affect the onset and development of rheumatoid arthritis (RA), but little is known about the reciprocal influence between microbiota composition and immunosuppressive drugs, and how this interaction may have an impact on the clinical outcome. The aim of this study was to characterize the intestinal microbiota in a groups of RA patients treatment-naïve, under methotrexate, and/or etanercept (ETN). Correlations between the gut microbiota composition and validated immunological and clinical parameters of disease activity were also evaluated. In the current study, a 16S analysis was employed to explore the gut microbiota of 42 patients affected by RA and 10 healthy controls. Disease activity score on 28 joints (DAS-28), erythrocyte sedimentation rate, C-reactive protein, rheumatoid factor, anti-cyclic citrullinated peptides, and dietary and smoking habits were assessed. The composition of the gut microbiota in RA patients free of therapy is characterized by several abnormalities compared to healthy controls. Gut dysbiosis in RA patients is associated with different serological and clinical parameters; in particular, the phylum of Euryarchaeota was directly correlated to DAS and emerged as an independent risk factor. Patients under treatment with ETN present a partial restoration of a beneficial microbiota. The results of our study confirm that gut dysbiosis is a hallmark of the disease, and shows, for the first time, that the anti-tumor necrosis factor alpha (TNF-α) ETN is able to modify microbial communities, at least partially restoring a beneficial microbiota.
Divergent Expression Patterns and Function of Two cxcr4 Paralogs in Hermaphroditic Epinephelus coioides
Authors: Lu Wei-Jia , Zhou Li , Gao Fan-Xiang , Sun Zhi-Hui , Li Zhi , Liu Xiao-Chun , Li Shui-Sheng , Wang Yang , Gui Jian-Fang
Published: September 2018

Chemokine receptor Cxcr4 evolved two paralogs in the teleost lineage. However, cxcr4a and cxcr4b have been characterized only in a few species. In this study, we identified two cxcr4 paralogs from the orange-spotted grouper, Epinephelus coioides. The phylogenetic relationship and gene structure and synteny suggest that the duplicated cxcr4a/b should result from the teleost-specific genome duplication (Ts3R). The teleost cxcr4 gene clusters in two paralogous chromosomes exhibit a complementary gene loss/retention pattern. Ec_cxcr4a and Ec_cxcr4b show differential and biased expression patterns in grouper adult tissue, gonads, and embryos at different stages. During embryogenesis, Ec_cxcr4a/b are abundantly transcribed from the neurula stage and mainly expressed in the neural plate and sensory organs, indicating their roles in neurogenesis. Ec_Cxcr4a and Ec_Cxcr4b possess different chemotactic migratory abilities from the human SDF-1α, Ec_Cxcl12a, and Ec_Cxcl12b. Moreover, we uncovered the N-terminus and TM5 domain as the key elements for specific ligand–receptor recognition of Ec_Cxcr4a-Ec_Cxcl12b and Ec_Cxcr4b-Ec_Cxcl12a. Based on the biased and divergent expression patterns of Eccxcr4a/b, and specific ligand–receptor recognition of Ec_Cxcl12a/b–Ec_Cxcr4b/a, the current study provides a paradigm of sub-functionalization of two teleost paralogs after Ts3R.
Acute Respiratory Infection Unveiling CPT II Deficiency
Authors: Blah Nicolas , Sudrié-Arnaud Bénédicte , Torre Stéphanie , Marret Stéphane , Bekri Soumeya , Tebani Abdellah
Published: September 2018

Carnitine Palmitoyl transferase 2 (CPT II) is involved in long-chain fatty-acid mitochondrial transport. Three clinical phenotypes of CPT II deficiency have been described: Lethal neonatal onset, infantile severe form, and the late onset more common muscular form. The muscular form of CPT II deficiency is characterized by pain crises and rhabdomyolysis triggered by energy-dependent factors. This form has been described as a benign condition; however, the acute crises are insidious and thus, pose a risk of death. We report a 3-year-old female child with an acute pulmonary infection and a concomitant rhabdomyolysis. The acylcarnitine profile was consistent with CPT II deficiency and a molecular study allowed the identification of the common missense variant (NM_000098.2: c.338C>T – p. Ser113Leu) at the homozygous state. The striking difference between the initial cause and the decompensation severity prompted us to consider other diagnoses. Deciphering the symptoms linked to CPT II deficiency among those of the initial decompensation results in initiating a timely a targeted therapy.
Ectopic Overexpression of Porcine Myh1 Increased in Slow Muscle Fibers and Enhanced Endurance Exercise in Transgenic Mice
Authors: Ahn Jin Seop , Kim Dong-Hwan , Park Hee-Bok , Han Sang-Hyun , Hwang Seongsoo , Cho In-Cheol , Lee Jeong-Woong
Published: September 2018

Myosin heavy chain (MyHC) isoforms consist of Myh7, Myh2, Myh1, and Myh4, which are expressed in skeletal muscle tissues during postnatal development. These genes influence the contraction–relaxation activity in skeletal muscles and are involved in determining muscle composition such as the proportion of fast-to-slow and/or slow-to-fast fiber types. Among them, Myh1 is associated with skeletal muscle contraction and is involved in both slow-to-fast and fast-to-slow transition. However, the muscle transition mechanism is not well understood. For this study, we first produced porcine Myh1 transgenic (TG) mice to study whether the ectopic expressed porcine Myh1 gene had any effects on muscle composition, especially on slow-type muscle components. Our results showed that the factors associated with slow muscles, such as Myh7, Myoglobin, Troponin (slow-type units), and cytochrome C, were highly expressed in the quadriceps muscles of Myh1 transgenic mice. Furthermore, the ectopic porcine MYH1 protein was located only in the slow-type muscle fibers of the quadriceps muscles in Myh1 transgenic mice. In physical endurance tests, Myh1 transgenic mice ran longer and further on a treadmill than wild-type (WT) mice. These data fully supported our hypothesis that Myh1 is associated with slow muscle composition, with overexpression of Myh1 in muscle tissues possibly being a new key in modulating muscle fiber types. Our study provides a better understanding of muscle composition metabolism, physical mobility, and genetic factors in muscle fatigue.
Antimicrobial Coatings from Hybrid Nanoparticles of Biocompatible and Antimicrobial Polymers
Authors: Galvão Carolina Nascimento , Sanches Luccas Missfeldt , Mathiazzi Beatriz Ideriha , Ribeiro Rodrigo Tadeu , Petri Denise Freitas Siqueira , Carmona-Ribeiro Ana Maria
Published: September 2018

Hybrid nanoparticles of poly(methylmethacrylate) synthesized in the presence of poly (diallyldimethyl ammonium) chloride by emulsion polymerization exhibited good colloidal stability, physical properties, and antimicrobial activity but their synthesis yielded poor conversion. Here we create antimicrobial coatings from casting and drying of the nanoparticles dispersions onto model surfaces such as those of silicon wafers, glass coverslips, or polystyrene sheets and optimize conversion using additional stabilizers such as cetyltrimethyl ammonium bromide, dioctadecyldimethyl ammonium bromide, or soybean lecithin during nanoparticles synthesis. Methodology included dynamic light scattering, determination of wettability, ellipsometry of spin-coated films, scanning electron microscopy, and determination of colony forming unities (log CFU/mL) of bacteria after 1 h interaction with the coatings. The additional lipids and surfactants indeed improved nanoparticle synthesis, substantially increasing the conversion rates by stabilizing the monomer droplets in dispersion during the polymerization. The coatings obtained by spin-coating or casting of the nanoparticles dispersions onto silicon wafers were hydrophilic with contact angles increasing with the amount of the cationic polymer in the nanoparticles. Against Escherichia coli and Staphylococcus aureus, bacteria cell counts were reduced by approximately 7 logs upon interaction with the coatings, revealing their potential for several biotechnological and biomedical applications.
Serum Urokinase-Type Plasminogen Activator Receptor Does Not Outperform C-Reactive Protein and Procalcitonin as an Early Marker of Severity of Acute Pancreatitis
Authors: Kolber Witold , Kuśnierz-Cabala Beata , Dumnicka Paulina , Maraj Małgorzata , Mazur-Laskowska Małgorzata , Pędziwiatr Michał , Ceranowicz Piotr
Published: September 2018

Severe acute pancreatitis (SAP) concerns 10–20% of acute pancreatitis (AP) patients and is associated with a poor prognosis and high mortality. An early prognosis of the unfavorable outcome, transfer to an intensive care unit (ICU) and the introduction of an adequate treatment are crucial for patients’ survival. Recently, the elevated circulating urokinase-type plasminogen activator receptor (uPAR) has been reported to predict SAP with a high diagnostic accuracy among patients in a tertiary center. The aim of the study was to compare the diagnostic utility of uPAR and other inflammatory markers as the predictors of the unfavorable course of AP in patients admitted to a secondary care hospital within the first 24 h of the onset of AP. The study included 95 patients, eight with a SAP diagnosis. Serum uPAR was measured on admission and in the two subsequent days. On admission, uPAR significantly predicted organ failure, acute cardiovascular failure, acute kidney injury, the need for intensive care, and death. The diagnostic accuracy of the admission uPAR for the prediction of SAP, organ failure, and ICU transfer or death was low to moderate and did not differ significantly from the diagnostic accuracy of interleukin-6, C-reactive protein, procalcitonin, D-dimer and soluble fms-like tyrosine kinase-1. In the secondary care hospital, where most patients with AP are initially admitted, uPAR measurements did not prove better than the currently used markers.
Impact of Tidal Phase on Inundation and Thrust Force Due to Storm Surge
Authors: Al Azad A. S. M. Alauddin , Mita Kazi Samsunnahar , Zaman Md. Wasif , Akter Marin , Asik Tansir Zaman , Haque Anisul , Hussain Mohammad Asad , Rahman Md. Munsur
Published: September 2018

Impact of storm surge largely varies depending on the tidal phase during the landfall of a tropical cyclone. This study investigates comparative variance in inundation condition and thrust force for an identical cyclone during low tide and high tide by applying a numerical model (Delft3D) and a semi-analytical model (DFM). A moderate strength cyclone, Mora, which made landfall on Bangladesh coast in May 2017 is selected to study its impact on land during low tide and high tide. Actual landfall time of Mora was during low tide. To study the impact of storm surge during high tide, a synthetic cyclone is created which has similar strength and track to that of Mora but makes landfall during high tide. The results show that inundation depth, inundation extent, and thrust force increase when a cyclone makes landfall during high tide compared to the condition when the cyclone makes landfall during low tide. But the relation between storm surge impact and tidal phase is not linear. It depends on the land topography of the location, direction of cyclone movement, direction and magnitude of water velocity and wind velocity, gradients of water surface and wind velocity, and proximity and position of the location with respect to cyclone track.
Effects of Different Melting Technologies on the Purity of Superalloy GH4738
Authors: Chen Zhengyang , Yang Shufeng , Qu Jinglong , Li Jingshe , Dong Anping , Gu Yu
Published: September 2018

The choice of melting technique is crucial for controlling the purity of a superalloy, which is especially important because purity has come to limit progress in the superalloy field. In this study, double- and triple-melting techniques were used to refine the GH4738 superalloy. Elemental analyses, inductively coupled plasma-atomic emission spectroscopy, X-ray diffraction analysis, scanning electron microscopy with energy-dispersive spectroscopy, high-temperature cupping machine, high-temperature fatigue testing machine, and Image-Pro Plus software were used to analyze and compare the contents of specific elements, the types and sizes of inclusions, the mechanical properties, and the probabilities of white spot formation using the two melting techniques. The effects of the different melting processes on the purity of the superalloy were systematically studied. In terms of controlling the presence of impurities, the triple-melting process resulted in lower levels of harmful N, S, and O impurities in the superalloy, the triple-melted superalloy also contained fewer types of inclusion of smaller sizes and in smaller amounts than the double-melted alloy. Triple melting also promotes tensile strength and fatigue life, and minimizes the probability of forming defects in the superalloy.
Synergistic Effects and Mechanism of Modified Silica Sol Flame Retardant Systems on Silk Fabric
Authors: Liu Chun , Xing Tieling , Wei Bingju , Chen Guoqiang
Published: September 2018

The nano-silica sol was prepared by sol-gel method, and the boric acid, urea, cyanoguanidine, melamine cyanurate (MCA), 1-hydroxyethane 1,1-diphosphonic acid (HEDP), and 6H-dibenz (C,E) (1,2) oxaphosphorin-6-oxide (DOPO) were added to the silica sol to modify the flame retardant through physical doping and chemical bonding. According to the formula proposed by Lewin, the calculation of flammability parameters were obtained by the limiting oxygen index meter, the micro calorimeter, the vertical burner, and the thermogravimetric analyzer proved that there was a synergistic or additive effect between the B/N/P flame retardant and the silica sol. Fourier transform infrared (FT-IR) spectrum, scanning electron microscopy, and pyrolysis gas chromatography-mass spectrometry were used to characterize the morphology, structure, and pyrolysis products of treated silk fabric and residues after combustion. The results show that the flame retardancy of silica-boron sol is mainly caused by endothermic reaction and melt covering reaction. Silicon-nitrogen sol acts as a flame retardant through endothermic reaction, release of gases, and melting coverage. Silicon-phosphorus sol achieves flame retardancy by forming an acid to promote formation of a carbon layer and melting coverage. Silica sol and other flame retardants show excellent flame retardanty after compounding, and have certain complementarity, which can balance the dosage, performance, and cost of flame retardants, and is more suitable for industrial development.
A Template-Free Microwave Synthesis of One-Dimensional Cu2O Nanowires with Desired Photocatalytic Property
Authors: Chen Rui , Wang Zuoshan , Zhou Qingqing , Lu Juan , Zheng Min
Published: September 2018

One-dimensional Cu2O nanowires were successfully prepared with a template-free microwave synthesis. Neither a surfactant was needed (to induce the growth), nor a long reaction time was required for this method. The structural investigation confirmed the successful preparation of Cu2O. The morphology images showed that the radial size of the Cu2O nanowires was 10 nm. The possible growth mechanism was hypothesized according to morphology evolution and references. A series of time-dependent experiments indicated that as time increased, Cu2O primary particles grew radially into nanowires under microwave energy irradiation. The condition-variable tests revealed that the suitable quantity of NaOH played a vital role in Cu2O nanowire formation. The photocatalytic property of the sample was investigated by degradation of methyl orange under the irradiation of visible light at room temperature. Benefiting from its unique large surface area, 4 mg of the prepared catalyst degraded 73% of methyl orange (10 mg L−1) in 120 min.
Mechanical Property Tests and Strength Formulas of Basalt Fiber Reinforced Recycled Aggregate Concrete
Authors: Fang Sheng-En , Hong Hua-Shan , Zhang Pei-Hui
Published: September 2018

In order to investigate the influence of basalt fibers (BFs) on the mechanical performance of recycled aggregate concrete (RAC), some groups of RAC specimens were first tested involving different types of fibers such as carbon fibers, steel fibers, polypropylene fibers and hybrid fibers. The main four indices for the investigation consisted of cube compressive strengths, axial compressive strengths, splitting tensile strengths and Young’s modulus. The effects of fiber volume fractions on the RAC slumps were also discussed. Meanwhile, the mechanical properties and failure modes of the BF-reinforced RAC were compared with those of other fiber-reinforced RAC and common concrete (CC). Subsequently the optimal volume fractions of BFs were explored for different mechanical properties within the volume fraction range of 0–0.2%. The back propagation neural networks were further applied to predict and validate the optimal BF fractions. Lastly, the general strength formulas, as well as the elastic modulus formula, for BF-reinforced RAC were deducted based on the specimen test results. It is found that the addition of fibers may improve the failure modes of RAC and different fibers present positive or negative effects on the mechanical properties. The optimal volume fractions of BF with respect to the four mechanical indices are 0.1%, 0.15%, 0.1% and 0.2% respectively. The proposed strength and elastic modulus formulas of BF-reinforced RAC provide satisfactory predictions with the test results and thus can be used as a reference in practice.
Dirac’s Method for the Two-Dimensional Damped Harmonic Oscillator in the Extended Phase Space
Authors: Gouba Laure
Published: September 2018

The system of a two-dimensional damped harmonic oscillator is revisited in the extended phase space. It is an old problem that has already been addressed by many authors that we present here with some fresh points of view and carry on a whole discussion. We show that the system is singular. The classical Hamiltonian is proportional to the first-class constraint. We pursue with the Dirac’s canonical quantization procedure by fixing the gauge and provide a reduced phase space description of the system. As a result, the quantum system is simply modeled by the original quantum Hamiltonian.
Common Fixed Point Results of (α − ψ, φ)-Contractions for a Pair of Mappings and Applications
Authors: Hussain Nawab , Radenovi’c Stojan , Zoto Kastriot
Published: September 2018

In this paper, we prove some fixed point theorems in a b-metric-like space setting using a new class of admissible mappings and types of α − k and ( ψ , ϕ )-contractive conditions. Our results are supported by the application of finding solutions of integral equations and generalizing some well-known results of the literature.
Rapid Solution of Optimal Control Problems by a Functional Spreadsheet Paradigm: A Practical Method for the Non-Programmer
Authors: Ghaddar Chahid Kamel
Published: September 2018

We devise a practical and systematic spreadsheet solution paradigm for general optimal control problems. The paradigm is based on an adaptation of a partial-parametrization direct solution method which preserves the original mathematical optimization statement, but transforms it into a simplified nonlinear programming problem (NLP) suitable for Excel NLP solver. A rapid solution strategy is implemented by a tiered arrangement of pure elementary calculus functions in conjunction with Excel NLP solver. With the aid of the calculus functions, a cost index and constraints are represented by equivalent formulas that fully encapsulate an underlining parametrized dynamical system. Excel NLP solver is then employed to minimize (or maximize) the cost index formula, by varying decision parameters, subject to the constraints formulas. The paradigm is demonstrated for several fixed and free-time nonlinear optimal control problems involving integral and implicit dynamic constraints with direct comparison to published results obtained by fundamentally different methods. Practically, applying the paradigm involves no more than defining a few formulas using basic Excel spreadsheet skills.
Design of a Hollow Fiber Supported Liquid Membrane System for Zn Speciation in Natural Waters
Authors: Fontàs Clàudia , Anticó Enriqueta , Salvadó Victòria
Published: September 2018

A supported liquid membrane-hollow fiber system (HFSLM) has been developed to determine zinc speciation in aquatic environments. The liquid membrane consisted of an organic solution of bis-(2-ethylhexyl)phosphoric acid (D2EHPA) impregnated in the microporous of a polypropylene hollow fiber. The membrane contacted both the donor solution, that contained the metal and the stripping solution, placed in the lumen of the hollow fiber, where the metal was preconcentrated. Different parameters affecting the Zn2+ transport efficiency have been evaluated such as the composition of both the donor and stripping solutions as well as the membrane phase. Extraction and transport efficiencies of free Zn(II) higher than 90% were obtained with a liquid membrane consisting of a 0.1 M D2EHPA solution in dodecane and a 0.1 M HNO3 solution as the stripping phase. The developed HFSLM was used to study the effect of different ligands (EDTA and citric acid) in the donor phase of Zn(II) transport and to investigate the selectivity of the membrane towards Zn when other metals were also present. Finally, the HFSLM system was successfully applied to estimate the free Zn(II) concentrations in three water samples from a mining area. Moreover, the HFSLM system facilitates the analytical determination of trace Zn(II) levels allowing the achievement of enrichment factors of around 700 in the stripping phase.
Phase Equilibria in the Ni-V-Ta Ternary System
Authors: Wang Cuiping , Liang Yuhui , Yang Shuiyuan , Zhang Jinbin , Huang Yixiong , Han Jiajia , Lu Yong , Liu Xingjun
Published: September 2018

Two isothermal sections of the Ni-V-Ta ternary system at 1200 °C and 1000 °C have been experimentally established using X-ray diffraction, electron probe microanalysis, energy dispersive spectroscopy, and differential scanning calorimeter with equilibrated key alloys. The equilibrium composition of each phase is measured by electron probe microanalysis and energy dispersive spectroscopy. The results indicate that: (1) nine three-phase and eight three-phase regions were confirmed in the isothermal section at 1200 °C and 1000 °C, respectively; (2) the C14 phase with a large solubility of about 51.2 at. % Ni was observed at 1200 °C, while it forms a single-phase region at 1000 °C; (3) a small liquid region was confirmed at 1200 °C, but disappeared at 1000 °C.
Adaptive Resistance Spot Welding Process that Reduces the Shunting Effect for Automotive High-Strength Steels
Authors: Yu Jiyoung
Published: September 2018

Although short-pitch resistance spot welding (RSW) significantly increases vehicle body strength, its application has been limited because of the associated shunting effect. In this study, a reference-based adaptive RSW process intended to minimize the shunting effect was proposed, and a related RSW system that controls welding current and power was developed to implement the adaptive method. The proposed RSW method compensates for the heat input loss caused by the shunting effect based on the estimated weld pitch and reference data obtained under suitable welding conditions. An exponential model was developed using a unique indicator (i.e., the ratio of the adaptive welding heat input to the reference welding heat input until the reference welding power curve peak) to estimate the weld pitch. A logistic growth model was next developed based on the relationship of the nugget diameter, heat input, and weld pitch to estimate the heat input compensation. A unique strategy using power control with a modified reference power curve was applied to supply the calculated heat input compensation. The experimental results intended to validate the proposed adaptive RSW process indicated that the proposed process effectively reduced the shunting effect and produced an improved nugget shape relative to the conventional RSW process.
Microfluidic-Based 3D Engineered Microvascular Networks and Their Applications in Vascularized Microtumor Models
Authors: Wang Xiaolin , Sun Qiyue , Pei Jianghua
Published: September 2018

The microvasculature plays a critical role in human physiology and is closely associated to various human diseases. By combining advanced microfluidic-based techniques, the engineered 3D microvascular network model provides a precise and reproducible platform to study the microvasculature in vitro, which is an essential and primary component to engineer organ-on-chips and achieve greater biological relevance. In this review, we discuss current strategies to engineer microvessels in vitro, which can be broadly classified into endothelial cell lining-based methods, vasculogenesis and angiogenesis-based methods, and hybrid methods. By closely simulating relevant factors found in vivo such as biomechanical, biochemical, and biological microenvironment, it is possible to create more accurate organ-specific models, including both healthy and pathological vascularized microtissue with their respective vascular barrier properties. We further discuss the integration of tumor cells/spheroids into the engineered microvascular to model the vascularized microtumor tissue, and their potential application in the study of cancer metastasis and anti-cancer drug screening. Finally, we conclude with our commentaries on current progress and future perspective of on-chip vascularization techniques for fundamental and clinical/translational research.
Antimicrobial Resistance in Class 1 Integron-Positive Shiga Toxin-Producing Escherichia coli Isolated from Cattle, Pigs, Food and Farm Environment
Authors: Colello Rocío , Krüger Alejandra , Conza José Di , Rossen John W. A. , Friedrich Alexander W. , Gutkind Gabriel , Etcheverría Analía I. , Padola Nora L.
Published: September 2018

The aim of this study was to investigate the presence of class 1 integrons in a collection of Shiga toxin-producing Escherichia coli (STEC) from different origins and to characterize pheno- and genotypically the antimicrobial resistance associated to them. A collection of 649 isolates were screened for the class 1 integrase gene (intI1) by Polymerase chain reaction The variable region of class 1 integrons was amplified and sequenced. Positive strains were evaluated for the presence of antimicrobial resistance genes with microarray and for antimicrobial susceptibility by the disk diffusion method. Seven out of 649 STEC strains some to serogroups, O26, O103 and O130 isolated from cattle, chicken burger, farm environment and pigs were identified as positive for intl1. Different arrangements of gene cassettes were detected in the variable region of class 1 integron: dfrA16, aadA23 and dfrA1-aadA1. In almost all strains, phenotypic resistance to streptomycin, tetracycline, trimethoprim/sulfamethoxazole, and sulfisoxazole was observed. Microarray analyses showed that most of the isolates carried four or more antimicrobial resistance markers and STEC strains were categorized as Multridrug-resistant. Although antimicrobials are not usually used in the treatment of STEC infections, the presence of Multridrug-resistant in isolates collected from farm and food represents a risk for animal and human health.
Synthesis and Structure-Activity Relationship of Daphnetin Derivatives as Potent Antioxidant Agents
Authors: Xia Yangliu , Chen Chen , Liu Yong , Ge Guangbo , Dou Tongyi , Wang Ping
Published: September 2018

In this study, daphnetin 1 was chosen as the lead compound, and C-3 or C-4-substituted daphnetins were designed and synthesized to explore the potential relationship between the antioxidant activities and the chemical structures of daphnetin derivatives. The antioxidant activities of the generated compounds were evaluated utilizing the free radical scavenging effect on 2,2′-diphenyl-1-picrylhydrazyl, 2,2′-azinobis-(3-ethylbenzthiazoline-6-sulfonate) cation, and the ferric reducing power assays, and were then compared with those of the standard antioxidant Trolox. The results showed that the catechol group was the key pharmacophore for the antioxidant activity of the daphnetins. The introduction of an electron-withdrawing hydrophilic group at the C-4 position of daphnetin enhanced the antioxidative capacity, but this trend was not observed for C-3 substitution. In addition, introduction of a a hydrophobic phenyl group exerted negative effects on the antioxidant activity in both the C-3 and C-4 substitutions. Among all of the derivatives tested, the most powerful antioxidant was 4-carboxymethyl daphnetin (compound 9), for which the strongest antioxidant activity was observed in all of the assays. In addition, compound 9 also displayed strong pharmaceutical properties in the form of metabolic stability. To summarize, compound 9 holds great potential to be developed as an antioxidant agent with excellent antioxidant activity and proper pharmacokinetic behavior.
Self-Assembly and Applications of Amphiphilic Hybrid POSS Copolymers
Authors: Chi Hong , Wang Mingyue , Xiao Yiting , Wang Fuke , K.S Joshy
Published: September 2018

Understanding the mechanism of molecular self-assembly to form well-organized nanostructures is essential in the field of supramolecular chemistry. Particularly, amphiphilic copolymers incorporated with polyhedral oligomeric silsesquioxanes (POSSs) have been one of the most promising materials in material science, engineering, and biomedical fields. In this review, new ideas and research works which have been carried out over the last several years in this relatively new area with a main focus on their mechanism in self-assembly and applications are discussed. In addition, insights into the unique role of POSSs in synthesis, microphase separation, and confined size were encompassed. Finally, perspectives and challenges related to the further advancement of POSS-based amphiphilics are discussed, followed by the proposed design considerations to address the challenges that we may face in the future.
Neuroprotective Role of Phytochemicals
Authors: Velmurugan Bharath Kumar , Rathinasamy Baskaran , Lohanathan Bharathi Priya , Thiyagarajan Varadharajan , Weng Ching-Feng
Published: September 2018

Neurodegenerative diseases are normally distinguished as disorders with loss of neurons. Various compounds are being tested to treat neurodegenerative diseases (NDs) but they possess solitary symptomatic advantages with numerous side effects. Accumulative studies have been conducted to validate the benefit of phytochemicals to treat neurodegenerative diseases including Alzheimer’s disease (AD) and Parkinson’s disease (PD). In this present review we explored the potential efficacy of phytochemicals such as epigallocatechin-3-galate, berberin, curcumin, resveratrol, quercetin and limonoids against the most common NDs, including Alzheimer’s disease (AD) and Parkinson’s disease (PD). The beneficial potentials of these phytochemicals have been demonstrated by evidence-based but more extensive investigation needs to be conducted for reducing the progression of AD and PD.
Galgeun-tang Attenuates Cigarette Smoke and Lipopolysaccharide Induced Pulmonary Inflammation via IκBα/NF-κB Signaling
Authors: Shin Na-Rae , Kim Chul , Seo Chang-Seob , Ko Je-Won , Cho Young-Kwon , Shin In-Sik , Kim Joong-Sun
Published: September 2018

Galgeun-tang water extract (GGWE) is used to treat various diseases such as the common cold, eczema and asthma in China and Korea. In this study, we investigated the anti-inflammatory effect of GGWE using a cigarette smoke (CS)- and lipopolysaccharide (LPS)-induced induced pulmonary inflammation mouse model. The mice were exposed to CS for a total of seven days (eight cigarettes per day for 1 h) and LPS was administered intranasally to mice on day 4. GGWE was administered by oral gavage at doses of 50 mg/kg or 100 mg/kg 1 h before exposure to CS. GGWE decreased inflammatory cell counts, and expression of inflammatory cytokines such as interleukin (IL)-6 and tumor necrosis factor alpha (TNF-α) in bronchoalveolar lavage fluid (BALF) from mice exposed to CS and LPS. GGWE reduced the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2), as well as the phosphorylation of inhibitor of kappa-B subunit alpha (IκBα) and nuclear factor kappa-B (NF-κB) in CS- and LPS-exposed mice. Histological examinations revealed that GGWE suppressed inflammatory cell infiltration into lung tissue compared to untreated CS- and LPS-exposed mice. In conclusion, GGWE effectively suppressed CS- and LPS-induced pulmonary inflammation. Our results indicate that GGWE may be used as a protective drug to control pulmonary inflammation diseases such as chronic obstructive pulmonary disease.
Similarity of Data from Bee Bread with the Same Taxa Collected in India and Romania
Authors: Urcan Adriana Cristina , Criste Adriana Dalila , Dezmirean Daniel Severus , Mărgăoan Rodica , Caeiro André , Graça Campos Maria
Published: September 2018

Bee Bread samples from Romania and India were analysed by microscopy and High Performance Liquid Chromatography with Diode Array Detection (HPLC/DAD) and compared with pollen from the correspondent taxa. The quantification of sugars, fructose/glucose ratio, total phenolics and flavonoids was also carried out. From the results was possible to identify Brassica and Eucalyptus samples that present similar HPLC/DAD profiles with the respective ultraviolet (UV) identification of the main compounds as Kaempferol-3-O-glycosides and Hydrocinnamic acid derivatives. The Fructose/Glucose (F/G) ratio and the total amounts of phenolics and flavonoids was in line with the prevalence of the specie identified. These coincident fingerprints gave the identification of the samples, as was previously proposed for bee pollens. This paper relates for the first time the achievement on the taxon carried out previously only for bee pollens. It was reported for the first time that this phenolic profile remains unchanged in the case of floral pollen (hand collected), bee pollen and bee bread. Despite the biochemical transformation that occurs during the fermentation of bee bread, it seems that these phenolic compounds are not affected and remain unchanged. Also, variables such as soil and climate do not seem to influence these compounds for the kind of samples under study.
Dibasic Derivatives of Phenylcarbamic Acid against Mycobacterial Strains: Old Drugs and New Tricks?
Authors: Malík Ivan , Csöllei Jozef , Solovič Ivan , Pospíšilová Šárka , Michnová Hana , Jampílek Josef , Čížek Alois , Kapustíková Iva , Čurillová Jana , Pecháčová Mária , Stolaříková Jiřina , Pecher Daniel , Oravec Michal
Published: September 2018

In order to provide a more detailed view on the structure–antimycobacterial activity relationship (SAR) of phenylcarbamic acid derivatives containing two centers of protonation, 1-[2-[({[2-/3-(alkoxy)phenyl]amino}carbonyl)oxy]-3-(dipropylammonio)propyl]pyrrolidinium oxalates (1a–d)/dichlorides (1e–h) as well as 1-[2-[({[2-/3-(alkoxy)phenyl]amino}carbonyl)oxy]-3-(di-propylammonio)propyl]azepanium oxalates (1i–l)/dichlorides (1m–p; alkoxy = butoxy to heptyloxy) were physicochemically characterized by estimation of their surface tension (γ; Traube’s stalagmometric method), electronic features (log ε; UV/Vis spectrophotometry) and lipophilic properties (log kw; isocratic RP-HPLC) as well. The experimental log kw dataset was studied together with computational logarithms of partition coefficients (log P) generated by various methods based mainly on atomic or combined atomic and fragmental principles. Similarities and differences between the experimental and in silico lipophilicity descriptors were analyzed by unscaled principal component analysis (PCA). The in vitro activity of compounds 1a–p was inspected against Mycobacterium tuberculosis CNCTC My 331/88 (identical with H37Rv and ATCC 2794, respectively), M. tuberculosis H37Ra ATCC 25177, M. kansasii CNCTC My 235/80 (identical with ATCC 12478), the M. kansasii 6509/96 clinical isolate, M. kansasii DSM 44162, M. avium CNCTC My 330/80 (identical with ATCC 25291), M. smegmatis ATCC 700084 and M. marinum CAMP 5644, respectively. In vitro susceptibility of the mycobacteria to reference drugs isoniazid, ethambutol, ofloxacin or ciprofloxacin was tested as well. A very unique aspect of the research was that many compounds from the set 1a–p were highly efficient almost against all tested mycobacteria. The most promising derivatives showed MIC values varied from 1.9 μM to 8 μM, which were lower compared to those of used standards, especially if concerning ability to fight M. tuberculosis H37Ra ATCC 25177, M. kansasii DSM 44162 or M. avium CNCTC My 330/80. Current in vitro biological assays and systematic SAR studies based on PCA approach as well as fitting procedures, which were supported by relevant statistical descriptors, proved that the compounds 1a–p represented a very promising molecular framework for development of ‘non-traditional’ but effective antimycobacterial agents.
Eu2+ and Eu3+ Doubly Doped ZnWO4 Nanoplates with Superior Photocatalytic Performance for Dye Degradation
Authors: Huang Yuan Ming , Li Ming Yu , Yang Long , Zhai Bao-gai
Published: September 2018

Eu2+ and Eu3+ doubly doped ZnWO4 nanoplates with highly exposed {100} facets were synthesized via a facile hydrothermal route in the presence of surfactant cetyltrimethyl ammonium bromide. These ZnWO4 nanoplates were characterized using scanning electron microscopy, transmission electron microscopy, X-ray diffraction, X-ray photoelectron spectrometry, diffuse UV-vis reflectance spectroscopy, photoluminescence spectrophotometry, and photoluminescence lifetime spectroscopy to determine their morphological, structural, chemical, and optical characteristics. It is found that Eu-doped ZnWO4 nanoplates exhibit superior photo-oxidative capability to completely mineralize the methyl orange into CO2 and H2O, whereas undoped ZnWO4 nanoparticles can only cleave the organic molecules into fragments. The superior photocatalytic performance of Eu-doped ZnWO4 nanoplates can be attributed to the cooperative effects of crystal facet engineering and defect engineering. This is a valuable report on crystal facet engineering in combination with defect engineering for the development of highly efficient photocatalysts.