bluuebunny/crossref_metadata_2025 huggingface dataset:
Sosialisasi dan Pemberian Bantuan Handsanitizer Otomatis Sebagai Bagian Pencegahan Dini Bahaya Covid-19 di TPST Sumberberas Muncar
Authors: Ikhwanul Qiram  , Adi Pratama Putra  , Dewi Sartika  , Rezki Nalandari
Published: September 2021

Ancaman penularan Virus Covid-19 salah satunya dipengaruhi oleh perilaku dan lingkungan kurang sehat pada suatu tempat manusia menjalani aktifitas. Seringkali tempat kerja belum cukup disiplin menjalankan protocol kesehatan. Minimnya pengetahuan dan kebiasaan memicu meningkatnya populasi yang rentan untuk tertular atau menularkan. Kegiatan ini bertujuan untuk memberikan sosialisasi tentang bahaya dan pencegahan penularan Covid-19 ditempat kerja. Edukasi yang diberikan meliputi langkah yang diambil atau protokol kesehatan dari pemerintah untuk diterapkan diantaranya, jaga jarak minimal 1 meter antar individu, selalu pakai masker jika beraktifitas di luar rumah, sering mencuci tangan, menggunakan handsanitizer dan lain sebagaianya. Dengan memberikan bantuan hand sanitizer otomatis mampu meminimalisir keborosan terhadap penggunaan cairan handsanitizer.
METHOD DEVELOPMENT AND VALIDATION OF DAPAGLIFLOZIN AND SAXAGLIPTIN BY RP-HPLC
Authors: Sana Tabassum  , Dr.M.Sathishkumar  , Dr.A.Mallik  , Dr.N.Jyothi
Published: September 2021

For the coincident evaluation of Dapagliflozin and Saxagliptin in bulk form; Chromatography was run through Intersil-ODS C18 column (250mm× 4.6mm, 5micron) Mobile phase containing Methanol: Water was pumped through the column in the ratio of 45: 55. The flow rate was 1ml/min. The temperature help was ambient i.e., upto300c. The optimized selected wavelength was 210nm. The retention time of Dapagliflozin and Saxagliptin was found to be 4.707min and6.68 min respectively. The %RSD of Dapagliflozin and Saxagliptin was found to be 0.031 and 0.036 respectively. The values of LOD and LOQ obtained from Dapagliflozin and Saxagliptin was 0.56, 1.69 and 0.57, 1.74 respectively. The retention time was decreased and the run time also decreased, so the method development was simple and economical that can be applied successfully for simultaneous estimation of combination of two anti- diabetic drugs; Dapagliflozin and Saxagliptin.
KEY WORDS: Dapagliflozin and Saxagliptin, RP-HPLC.
Novel VDBA based universal filter topologies with minimum passive components
Authors:   Institute of Microengineering and Nanoelectronics (IMEN), University Kebangsaan Malaysia (UKM), Selangor, Malaysia, Albrni Musa Ali , Faseehuddin Mohammad ,   Institute of Microengineering and Nanoelectronics (IMEN), University Kebangsaan Malaysia (UKM), Selangor, Malaysia, Sampe Jahariah ,   Institute of Microengineering and Nanoelectronics (IMEN), University Kebangsaan Malaysia (UKM), Selangor, Malaysia, Md Ali Sawal Hamid ,   Department of Electrical, Electronic and Systems Engineering, University Kebangsaan Malaysia (UKM), Selangor, Malaysia
Published: September 2021

In this research, voltage differencing buffered amplifier (VDBA) is utilized in designing three novel multi-input single output (MISO) topologies of universal filters. The designed filters employ minimum number of passive components and did not require any passive component matching condition. Two of the designed filters can work in dual mode of operation simultaneously. The designed filters have inbuilt tunability property. The nonideal gain analysis and sensitivity analysis of the filters are also carried out to study the effect of process variations and process spread on the filter responses. The complete layout of the VDBA is designed using 0.18μm Silterra Malaysia process design kit (PDK) in Cadence design software. The parasitic extraction is done using Mentor graphics Calibre tool. The postlayout simulations bear close resemblance with the theoretical predictions.
THE PREVALENCE OF UNHEALTHY SNACKING BEHAVIOUR AND ITS ASSOCIATION WITH INDIVIDUAL AND ENVIRONMENTAL FACTORS AMONG COLLEGE STUDENTS IN KUCHING, SARAWAK
Authors: Cheah Yong Xiang  , Cheah Whye Lian
Published: September 2021

Unhealthy snacking behaviour among young people is a growing public health concern because of its negative consequences on health. This study was to determine the prevalence of unhealthy snacking behaviour and its determinants among college students in Kuching. In this cross-sectional study, 12 colleges in Kuching were stratified into private and government colleges. Three private and three government colleges were selected through a stratified random sampling method. A total of 422 respondents (male 49.5%, female 50.5%) were recruited in this study. A self-administered questionnaire was used to gather data regarding unhealthy snacking behaviour and its determinants (gender, food preferences, type of school and courses, taste-and-sensory perception, nutritional knowledge, perceived self-efficacy, and cost/price sensitivity, perceived parental control, easy accessibility, and media advertisements influence) among respondents. The survey was conducted online via e-mail/Whatsapp. Multiple binary logistic regression analysis was used to analyse the data. A quarter of the respondents (24.6%) practised unhealthy snacking behaviour. More than half of the respondents (58.3%) consumed unhealthy snacks one to three times per week. A minority of the respondents (17.1%) claimed that they did not consume any unhealthy snacks for the past month. The final model explained 15.7% of the total variance. Taste-and-sensory perception (Adjusted OR = 2.20, 95%CI [1.55, 3.13], p < 0.001) and nutritional knowledge (Adjusted OR = 1.48, 95%CI [1.12, 1.97), p < 0.05) were positively associated with unhealthy snacking behaviour among respondents. The present study suggested the stakeholders concentrate on nutritional knowledge and taste-and-sensory perception among college students in future intervention development
Platinum and gold placer from Tugidak Island, Alaska: Platinum-group minerals and their inclusions, gold, and chromite mineralogy
Authors: Belkin Harvey E. , Grosz Andrew E.
Published: September 2021

Black sand beach placers from Kodiak, Sitkinak, and Tugidak Islands, Alaska, have been mined intermittently for gold and minor platinum-group alloys for more than 100 years. High-grade platinum-rich magnetic separate and accompanying black sand from the southern beach placer of Tugidak Island were studied using electron microprobe WDS and scanning electron microscope EDS; mineral classification and identification were based on these techniques. The major platinum mineral is isoferroplatinum, followed by minor tetraferroplatinum and tulameenite, and rare ferronickelplatinum. Two types of alteration were identified in about 3–4% of the alloy grains: rim formation involving Pt loss and increased Fe, Ni, and/or Cu, and fracturing and vein filling by Cu-rich alloy. Ruthenium-Ir-Os-Pt alloys occur as inclusions and veins as well as form part of composite grains. Ten percent of the alloy grains contain a large variety of platinum-group minerals (PGM). Inclusions of cuprorhodsite, malanite, cuproiridsite, laurite, erlichmanite, cooperite, braggite, bowieite, kashinite, miassite, hollingworthite, irarsite, sperrylite, stillwaterite, genkinite, stibiopalladinite, keithconnite, zvyagintsevite, and probable palladodymite and vincentite were identified. Two unidentified inclusion phases also occur. Most of the PGM inclusions are primary and were trapped by a growing crystal from a melt; some inclusions exhibit textures that suggest trapping of an As,Te,S-rich immiscible melt. Secondary inclusions and evidence of deformation were observed in a few alloy grains. Associated with PGM inclusions or as separate inclusions are various base-metal sulfides. Two silicate-melt inclusions in one isoferroplatinum grain have an andesite–shoshonite composition. Minor gold and Ag-rich gold in the high-grade magnetic separate contain magnetite, pyrrhotite, and chromite inclusions. The gold composition suggests that their sources are the numerous quartz veins and apophyses related to granitoids on Kodiak Island. The composition of the placer chromite is similar to chromite from the Border Ranges mélange fault system and suggests that the Uyak Complex ultramafic and mafic rocks are part of a supra-subduction-zone ophiolite and are the source of the platinum-group minerals.
Presentation of Russian quantitative adverbs for foreign students: the system of exercises. Part 2. Lexemes немного, мало and their derivatives
Authors: Панков Ф.И. , Гулидова Е.Н.
Published: September 2021

В статье рассматриваются особенности представления русской адвербиальной лексики в иноязычной аудитории. В результате функционально-коммуникативного анализа квантитативов немного, мало и мотивированных ими лексем было создано их интегральное лингводидактическое описание. Оно послужило основой для разработки системы упражнений и заданий (СУЗ), направленных на обучение инофонов корректному употреблению названных лексем в речи. Фрагмент разработанной СУЗ представлен в данной статье.

The articles deals with the peculiarities of presenting Russian adverbs at the lessons of Russian as a foreign language. The results of the functional communicative analysis of quantitative words немного, мало, and their derivatives carried out by the authors allowed to create the integral linguodidactic description of the chosen words. This description laid the foundation for the working-out of a system of exercises aimed at teaching foreign students the correct use of the above-said lexical items in their speech. The article presents the fragment of this system.
Teaching the adverbial participle to Hispanic students on the lessons of Russian as a foreign language
Authors: Валеева Д.Р.
Published: September 2021

Цель статьи – сопоставить русское деепричастие c испанским герундием и описать специфику презентации материала по теме «Деепричастие» испаноговорящим студентам. Методология работы основана на анализе и обобщении научно-педагогических трудов отечественных и зарубежных ученых в области преподавания грамматики. Несмотря на определенные сходства русского деепричастия с испанским герундием, нельзя отождествлять исследуемые грамматические формы. Автором также обосновывается целесообразность применения сопоставительного метода в преподавании, поскольку сравнение деепричастия с герундием на занятиях позволяет испаноязычным учащимся быстрее усвоить материал, избежать ошибок в употреблении деепричастия и, следовательно, достичь наилучших результатов в области овладения русской грамматикой.

The purpose of the article is to reveal the features of similarity and difference between the adverbial participle and the Spanish gerund and describe the specifics of the presentation of the material on the topic «The adverbial participle» for the Hispanic audience. The methodology of work is based on the analysis and generalization of scientific and pedagogical papers of domestic and foreign scientists in the field of teaching grammar. When writing the article, the author also used textbooks on the Russian language for foreign students.
The analysis of the scientific literature made it possible to reveal certain similarities between the adverbial participle and the Spanish gerund. But the article reveals the fact that it is nevertheless impossible to identify the investigated grammatical forms.
The author justifies the advisability of applying a comparative method in teaching. Comparison of Russian adverbial participle with Spanish gerund during classes allows Hispanic students more quickly learn the material, avoid mistakes in the use of adverbial participles and, consequently to achieve the best results in the field of mastering Russian grammar.
The role of an audiovisual course in teaching Russian as a foreign language to students of exchange and applied programs
Authors: Борченко В.С.
Published: September 2021

В данной статье рассматривается применение аудиовизуального метода как одного из важнейших форм обучения РКИ в современном образовательном процессе. В ходе исследования выявлен ряд преимуществ аудиовизуального курса, раскрыты способы и возможности его использования в целях развития аудиовизуальной компетенции, в том числе повышение уровня коммуникативной компетенции в конкретных условиях обучения в иностранной аудитории в рамках реализации коммуникативного, личностно-ориентированного и компетентностного подходов. Кроме того, определен дидактический потенциал аудиовизуального метода обу-чения, названы его особенности, указаны способы его реализации на практических занятиях по РКИ на начальном этапе обучения. Разработаны и апробированы дополнительные занятия, в основе которых лежат аутентичные видеоматериалы, рассчитанные на учащихся, владеющих русским языком в объеме уровней А1–А2.

This article is about an audiovisual method as one of the most important methods in teaching Russian as a foreign language in modern educational processes. Within the given research a lot of advantages of an audiovisual course were revealed including disclosed ways and opportunities of using it with target development audiovisual competence, raising communicative competence level under particular conditions of teaching foreign students, implementing communicative, and personality-oriented competence techniques. Besides, we have specified a didactic potential audiovisual method of teaching, have defined means of its realization at practical lessons of Russian as a foreign language at the beginning stage of teaching. We also have established and approbated additional lessons with authentic video material for students language level А1–А2.
Research on the use of network resources by students studying Russian at Xinjiang universities
Authors: Цзян Ц. , Самойлова В.А.
Published: September 2021

В настоящей работе проводится анализ использования сетевых ресурсов студентами университетов Синьцзяна. Исследование проведено путем сбора и обобщения соответствующей информации, а также изучения результатов опроса студентов. Статья включает рекомендации для студентов и преподавателей по использованию веб-ресурсов.

The aim of the study is to analyze the use of network resources by students studying Russian at Xinjiang universities. In this article, a study and analysis of the use of network resources of students in Xinjiang is carried out, by collecting and summarizing relevant information and studying the results of a survey of students. The article is devoted to recommendations for the use of web resources for students and teachers.
TO THE QUESTION OF THE TRANSLATION COMPETENCE’S STRUCTURE OF TURKISH STUDENTS STUDYING RUSSIAN AS A FOREIGN LANGUAGE
Authors: Шеремет О.В.
Published: September 2021

Изучение РКИ предполагает формирование переводческой компетентности студента. Именно она является обязательной составляющей профессиональной готовности. В данной статье на основании проведенного анализа научных источников была сделана попытка уточнить понятие переводческой компетентности. Также предложено описание субкомпетенций, входящих в ее состав: психофизиологической, предметной, билингвальной коммуникативной и инструментальной.

According to the analysing of statistical returns and scientific-and-methodological resources, we have found on the example of the Republic of Turkey’s higher educational establishments, that the study of Russian as a foreign language involves the formation of student’s translation competence. It’s an obligatory component of the professional readiness of the future graduate. In this article, based on the analysis of scientific sources, the attempt to clarify the concept of translation competence had been made. Also had been proposed the description of the subcompetencies that translation competence is made of, such as psycho physiological, subject, bilingual communicative and instrumental.
SYNTACTIC TIME AND POETIC TEXT
Authors: Милованова М.С.
Published: September 2021

Монография Т.Е. Шаповаловой посвящена осмыслению категории синтаксическое время. Время как синтаксическая категория и обязательный компонент предикативности исследуется на материале поэтического текста, в котором все грамматические элементы преображаются. В частности, синтаксемы и субстантивные обороты – носители временнóй семантики получают дополнительные субъективно-модальные оттенки, событийные коннотации, сопутствующие созначения (пространственные, условные и др.). Рассматриваются также такие принципиальные для понимания синтаксической проблемы времени теоретические вопросы, как абсолютное и относительное время, временнáя определенность и временнáя неопределенность, предикативные свойства синтаксемы, субстантивного оборота и др.

Monograph by prof. T.E. Shapovalova is devoted to understanding of the category of syntactic time. Time as a syntactic category and an obligatory component of predicativity is considered on the material of a poetic text, in which all grammatical elements are transformed - in particular syntaxemes as the carriers of temporal semantics receive additional subjective-modal shades, event connotations, and accompanying connotations (spatial, conditional, etc.). We also considered such fundamental for understanding of the syntactic problem of time as absolute and relative time, temporal definiteness and temporal uncertainty, predicative properties of substantive turnover, etc.
NOVEL CARDIONEUROLOGICAL CORRELATIONS IN ATRIAL FIBRILLATION
Authors:   Department of Neurology, University Emergency Hospital, Bucharest, Nistor Ileana Raluca ,   „Carol Davila“ University of Medicine and Pharmacy, Bucharest, Gherasim Leonida ,   Department of Neurology, University Emergency Hospital, Bucharest,   „Carol Davila“ University of Medicine and Pharmacy, Bucharest
Published: September 2021

The relationship between atrial fibrillation and stroke is both a classical and a complicated one. In the current review we aimed at defining and refining of this relationship through the view of new clinical and pathogenic data, the issue of subclinical atrial fibrillation being a major issue.
NEUROCYSTICERCOSIS PRESENTING WITH PAROXYSMAL SENSORY DISTURBANCE
Authors:   Department of Neurology, Fundeni Clinical Institute, „Carol Davila“ University of Medicine and Pharmacy, Bucharest, Dulamea Adriana Octaviana
Published: September 2021

Author reports the case of a 28 years-old woman presenting episodes of paresthesia of the right arm with duration of approximately 4 days which remitted spontaneously, followed after two years by episodes of right hemiparesthesia. Brain MRI followed by brain stereotactic biopsy established the diagnosis of neurocysticercosis. Since electroencephalography showed no spike-wave abnormalities it was difficult to establish if symptoms were secondary to parietal lesion itself or were focal sensory seizures. After treatment with albendazole, methylprednisolone and sodium valproate the patient had a good recovery.
SCORING SLEEP: THE RULES FOR LOOKING INSIDE
Authors:   Academica Clinic, Boghez Floriana , Mandruta Ioana ,   Emergency University Hospital of Bucharest
Published: September 2021

Polysomnography is the most comprehensive sleep study, a multi-parametric recording test (electroencephalography, electrooculogram, chin and limbs electromyogram, respiratory and cardiac functions and permanent video-recording), used as an important diagnostic tool for the sleep disorders. Sleep architecture or the sleep macrostructure is a term used to describe the divisions of sleep into specific sleep stages using electro encephalographic (EEG), electrooculographic (EOG) and electromyographic (EMG) criteria: NREM (non-rapid eye movements) stages – N1, N2 and N3, and REM (rapid eye movements) stage.
MEDULLOBLASTOMA – CASE PRESENTATION IN AN ADULT PATIENT
Authors:   Neurology Department, University Emergency Hospital, Bucharest, Roceanu Adina , Marinescu Andreea ,   Radiology Department, University Emergency Hospital, Bucharest, Bajenaru Ovidiu ,   Neurology Department, University Emergency Hospital, Bucharest
Published: September 2021

The medulloblastoma is an infratentorial, rapidly growing embryonic tumor that arises in the posterior part of the cerebellar vermis and neuroepithelial roof of the fourth ventricle. It is frequent in children relatively uncommon in adults. Medulloblastoma is also named infratentorial primitive neuroectodermal tumor (PNET).We present a case of 28 year old male diagnosed with medulloblastoma in our clinic.
MENINGIOMA – DIFFERENT LOCALIZATIONS AND PRESENTATIONS
Authors:   Colentina Clinical Hospital, Bucharest, Romania, Stefanescu Daniela , Stefanescu Vlad Claudiu ,   Colentina Clinical Hospital, Bucharest, Romania, Cojocaru Inimioara Mihaela ,   Colentina Clinical Hospital, Bucharest, Romania,   “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania
Published: September 2021

Depending on localization, the same type of expansive process may result in different clinical presentations. Such is the case of our patients. Patient A suffered her first focal motor seizure while sitting, which was briefly followed by loss of consciousness. Clinical examination revealed initial stupor, which reversed to fully conscious state, and by brisk involuntary clonoid movements involving her left side of her body, which were self-limited within several minutes. Brain MRI revealed frontal and parietal enhancing lesions protruding into the right hemisphere (arrows).
VISUAL DISTURBANCES IN PARKINSON’S DISEASE PATIENTS
Authors:   Neurology Department, “Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania, Tohanean Nicoleta , Muntean Lucia ,   Neurology Department, “Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania,   Department of Clinical Neurophysiology, University of Göttingen, Göttingen, Germany, Demea Horea ,   Ofta Review Clinic Cluj-Napoca, Romania, Perju-Dumbrava Lacramioara ,   Neurology Department, “Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania
Published: September 2021

Along with the motor symptoms, Parkinson’s disease (PD) patients experience a wide range of non-motor problems including visual disturbances. These are multifaceted, but often underreported as such. In a visual survey questionnaire, 78% PD patients reported at least one problem related to vision or visuospatial functioning. The most frequent encountered problems are impaired contrast sensitivity, color discrimination, visuospatial processing, ocular or eyelid movements and diplopia followed by visual misperceptions and hallucinations. Some patients report dry eyes, ocular pain or photophobia. The pathophysiological basis of the visual disturbances is not completely understood. Changes in the visual cortex were detected with functional MRI before the visual symptoms were clinically evident. Further studies are necessary to determine how these changes will contribute to development of visual symptoms in PD patients. Other authors consider a dopaminergic deficit in the retina to be responsible for some of these symptoms, being known that dopamine is the major neurotransmitter in the amacrine and interplexiform cells in the retina. Visual hallucinations are likely to be a result of disruption across related yet diverse neural circuitry. The therapy is only symptomatic and not always satisfactory. It includes ophthalmological treatment and specific treatment for hallucinations. Optical Coherence Tomography (OCT) is a new investigation method who offers quantitative morphology of gross retinal histology. The thinning of the peripapillary retinal nerve fiber layer was observed in PD. Some studies mentioned that macular thickness measured by the OCT could be a promising biomarker of PD. This work shows how complex the visual problems in PD patients can be and the importance of a thorough and multidisciplinary approach.
INTERFERON ALPHA2B INDUCED DOPAMINE CHANGES IN CUTANEOUS MELANOMA PATIENTS
Authors:   “Carol Davila” Clinical Hospital of Nephrology, Bucharest, Romania, Ene Corina-Daniela , Nicolae Ilinca ,   Research Department in Dermatology, “Victor Babes” Clinical Hospital of Tropical and Infectious Diseases, Bucharest, Romania
Published: September 2021

Objective. The authors interest was focused on interferon impact on dopamine status and on the relation between negative emotional state and dopamine in melanoma patients. Methods. 60 patients diagnosed with malignant melanoma in 1st or 2nd clinical stage were included in the first 56 days after surgical removal of the tumor in an observational prospective study. The patients were divided in 2 groups: group A that included 30 cases treated with 10MU interferon alpha2b/mp three times a week for one year and group B that included 30 cases with no adjuvant treatment. Urinary dopamine (ELISA) was evaluated before treatment with interferon alpha2b, after 1, 6, 12 months of treatment and after 6 months from the end of the treatment. Neuropsychiatric disorders were grouped according to their frequency in melanoma patients. Results. Neuropsychiatric disorders associated with the treatment with interferon were: irritability, asthenia and fatigability, sleep disorders, anxiety, cognitive disorders, somatic symptoms. The treatment with interferon altered dopamine metabolism. Dopamine returned to the pretherapeutical values at six months after interferon was stopped. Patients with low levels of urinary dopamine had a high, statistically significant risk of developing depression during interferon treatment (OR=2.647, IC=2.186-3.014, p=0.0216). Conclusions. Low dopamine might have a major role in the development of depression secondary to interferon treatment.
NEONATAL STROKE DUE TO VARICELLA ARTERIOPATHY
Authors:   Department of Neurology, Narayana Medical College Hospital, Chinthareddypalem, Nellore, Andhra Pradesh, India, Sampath Kumar N.S. , Umamaheswara Reddy V. ,   Department of Radiology, Narayana Medical College Hospital, Chinthareddypalem, Nellore, Andhra Pradesh, India, Amit Agrawal ,   Department of Neurosurgery, Narayana Medical College Hospital, Chinthareddypalem, Nellore, Andhra Pradesh, India, Ganesh V. ,   Department of Neurology, Narayana Medical College Hospital, Chinthareddypalem, Nellore, Andhra Pradesh, India, Mithilesh A. ,   Department of Radiology, Narayana Medical College Hospital, Chinthareddypalem, Nellore, Andhra Pradesh, India
Published: September 2021

Varicella zoster is one of the common infective etiological factors known to produce arteriopathy of cerebral vasculature. Varicella zoster infection spreads transaxonally first to the adventitia and later transmurally to intima. Primary infection or reactivation of varicella zoster, both are associated with involvement of cerebral vessels of large as well as of small calibre varicella zoster associated arteriopathy was reported up to 12 months after the infection. Recurrence of strokes are seen post varicella infection. Hence the identification of varicella zoster as an etiological agent of ischemic stroke in neonatal age group patients is necessary and requires follow-up. Other neurologic sequelae following varicella infection are aneurysm formation leading to subarachnoid and cerebral haemorrhage, carotid dissection and rarely peripheral arterial disease. Due to lack of adequate epidemiological, neuroimaging and laboratory data, guidelines for treatment of varicella ateriopathy are not clear.
The cannabinoids – important therapeutic approach in the field of oncology
Authors:   “Carol Davila“ University of Medicine and Pharmacy, Bucharest, Romania, Blebea Nicoleta Mirela , Bucur Laura Adriana ,   Disciplines of Pharmacognosy and Clinical Pharmacy, Faculty of Pharmacy, “Ovidius“ University, Constanta, Romania, Negreș Simona ,   Department Discipline of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, “Carol Davila“ University of  Medicine and Pharmacy, Bucharest, Romania
Published: September 2021

Oncological diseases are the most common cause of death worldwide, it is estimated that 25% of the population will face the diagnosis of cancer during life. Phytochemicals such as cannabinoids (CBs) have been used in various branches of medicine for their properties, and the discovery of the anti-tumor, anti-emetic and anti-inflammatory effects of some of these substances has encouraged their use in oncology. Phytocannabinoids, cannabidiol (CBD) and Δ-9-tetra-hydrocannabinol (THC), have numerous anti-emetic, analgesic, orexigenic, anti-inflammatory / immunosuppressive pharmacodynamic effects. In recent years, studies have been aimed at evaluating their efficacy as antineoplastic agents. Much in vivo and in vitro research has demonstrated the efficacy of CBs on certain tumor cell lines, highlighting their potential role in the complementary treatment of cancer. This paper suggests that exploring the molecular mechanisms induced by CBs in cancer cells may contribute to the development of effective treatments in oncological diseases.
Analisis Faktor-Faktor Yang Mempengaruhi Stres Kerja Karyawan Pada PT. Bosowa Berlian Motor Luwuk
Authors: Milang Ichsan
Published: September 2021

Penelitian yang digunakan dalam penelitian ini adalah jenis penelitian kualitatif yang di kuantitatifkan dengan menggunakan skala likert. Sampel yang digunakan sebanyak 16 responden yang menjadi karyawan pada PT. Bosowa Berlian Motor Luwuk. Teknik analisis data yang digunakan dalam penelitian ini adalah analisis regresi linier berganda dengan hasil persamaan Y = 19,523 + 0,182X1 + 0,163X2. Nilai konstanta (a) sebesar 19,523 berarti jika variabel faktor stres kerja yang berasal dari pekerjaan (X1) dan faktor stres kerja yang berasal dari luar pekerjaan (X2) benilai nol atau tidak ada maka nilai stres kerja (Y) sebesar 19,523. Nilai koefisien korelasi sebesar 0,803 menunjukkan bahwa hubungan antara variabel bebas faktor stres kerja yang berasal dari pekerjaan (X1) dan faktor stres kerja yang berasal dari luar pekerjaan (X2) yang digunakan dalam penelitian ini mempunyai hubungan yang sangat kuat terhadap variabel terikat stres kerja (Y) dengan nilai interval 0,80 – 1,000. Nilai koefisien determinasi (R2) sebesar 0,644 menunjukkan besarnya sumbangan variabel bebas faktor stres kerja yang berasal dari pekerjaan (X1) dan faktor stres kerja yang bearasal dari luar pekerjaan (X2) terhadap variabel terikat stres kerja (Y) adalah sebesar 64,4% (0,644 x 100%), sisanya sebesar 35,6% (100% - 0,644%) dipengaruhi oleh variabel lain yang tidak diteliti. Nilai thitung > t table dengan nilai taraf signifikansi variabel faktor stres kerja yang berasal dari pekerjaan (X1) sebesar 0,002 dan variabel stres kerja yang berasal dari luar pekerjaan (X2) sebesar 0,004 yang artinya terdapat pengaruh signifikan secara parsial. Hasil uji f secara simultan diperoleh nilai f hitung sebesar 12,657 dengan sig 0,001, lebih besar dari nilai F Tabel adalah 3,805 Maka Hasil penelitian ini menunjukan bahwa faktor stres kerja yang berasal dari pekerjaan dan dari luar pekerjaan berpengaruh signifikan terhadap stres kerja karyawan pada PT. Bosowa Berlian Motor Luwuk.
Review of current guidelines for the treatment of type 2 diabetes
Authors: Kaminsky O. V.
Published: September 2021

According to the WHO, diabetes is one of the five most dangerous chronic non-communicable diseases in the world. The annual increase in the number of patients with diabetes in Ukraine is about 5-10%. In 2020, the WHO published new guidelines for the diagnosis and treatment of diabetes and updated its classification. Along with the already familiar type 1 and 2 diabetes and gestational diabetes, a new category of disease has emerged – hybrid forms of diabetes. In the section «Pharmacological management of diabetes» the WHO gives priority to the level of glycemia, the control of which avoids the development of microvascular complications of type 2 diabetes. Initial treatment, according to the WHO 2020, should begin with the appointment of metformin - a drug of the first line of treatment of patients with this disease. It is important that metformin does not cause weight gain, does not provoke hypoglycemia and is recommended for the treatment of people who do not reach the desired level of glycemia through diet and physical activity. Secondgeneration sulfonylureas can be used as an initial first-line treatment when metformin is contraindicated or intolerant. However, this is quite rare: in most cases, metformin is well tolerated by patients if administered gradually. That is, metformin, and, if necessary, sulfonylureas - is an effective, safe and affordable choice compared to expensive novelties, the effectiveness and safety of which have not been proven in long-term studies. In addition, in type 2 diabetes, metformin drugs will form additional effects: cardioprotection, oncoprotection, hepatoprotection, nephroprotection, additional hypoglycemic effect and will fight insulin resistance.
Pharmacotherapy of liver cirrhosis and its complications
Authors: Bentsa T. M.
Published: September 2021

This article provides information about the pharmacotherapy of liver cirrhosis (LC) and its complications, such as variceal hemorrhage, ascites, increased risk of bacterial infection, spontaneous bacterial peritonitis, hepatic encephalopathy, hepatorenal syndrome

LC is a major healthcare problem and is associated with an increased mortality due to the development of complications. LC is currently the 11th most common cause of death globally. Prognosis of LC is highly variable and influenced by several variables, such as etiology, severity of liver disease, presence of complications and comorbidities. In advanced cirrhosis, survival decreases to one or two years.

Pharmacotherapy for LC should be implemented in accordance with up-to-date guidelines and in conjunction with aetiology management, nutritional optimisation and patient education. The main treatment of uncomplicated ascites is diuretics such as spironolactone in combination with a loop diuretic. For treatment refractory ascites vasoconstrictors and albumin are recommended. Antibiotics play a well-established role in the treatment and prevention of spontaneous bacterial peritonitis. For hepatorenal syndrome, the administration of vasopressor terlipressin and albumin is recommended. Endoscopic treatment is used for variceal bleeding (for example, ligation for esophageal varices and tissue glue for gastric varices). A shunt (TIPS) is used to treat severe or repeat variceal hemorrhage or refractory ascites. Non-selective beta-blockers effectively reduce variceal re-bleeding risk in LC patients with moderate/large varices.

Thus, the treatment of LC as one of the most formidable multiorgan pathologies involves a comprehensive approach aimed at the correction of the main pathology and the treatment and prevention of its complications.
The diabetes mellitus and oncopathоlogy
Authors: Zhuravlyova L. V. , Sokolnikova N. V.
Published: September 2021

The number of newly diagnosed cases of diabetes mellitus (DM) and various cancers is growing every year. Obviously, the presence of one disease significantly complicates the course of another. But it is still unclear whether diabetes potentiates the development of cancer or oncopathology will be the cause of carbohydrate metabolism disorders, and what effect the use of antidiabetic drugs has on the course of cancer.The purpose of this review was to establish a causal relationship between diabetes, hypoglycemic therapy and the development of oncopathology.Results. The hyperinsulinemia and hyperglycemia consistently increase the likelihood of tumor development not only in patients with diabetes but also in patients with prediabetes, and lead to some cancers, such as pancreatic, liver, stomach, colon, breast, kidney, lungs, etc. In addition, increasing or decreasing the risk of cancer may be a side effect of some antidiabetic drugs.Conclusions. Diabetes is a risk factor for cancer, especially hepatocellular, hepatobiliary, pancreatic, breast, ovarian, endometrial and gastrointestinal cancers. In general, treatment with sulfonylureas can increas the risk of cancer, while treatment associated with improved insulin resistance, such as metformin, may reduce this risk.It is obvious that many existing studies have ambiguous results and require correction due to organizational errors, ie it is necessary to conduct additional carefully planned and properly organized studies. In addition, given the importance of both diseases, we believe that diabetic patients need routine screening and orientation of medical personnel for early detection of oncopathology.
On the issue of obesity in menopause
Authors: Knyazkova I. I.
Published: September 2021

Obesity is one of the most important medical and social problems, which becomes especially important in women during menopause. Reasons for weight gain after menopause include decreased physical activity and natural aging of the body, as well as estrogen deficiency. A better understanding of the causes and mechanisms of weight gain during this period of a woman’s life allows us to believe that obesity is not inevitable and can be effectively resisted by implementing the principles of a healthy lifestyle, as well as, if necessary, using drug correction.
Fixed combination of lercanidipine with enalapril - pharmacological features, clinical feasibility, advantages in the treatment of hypertension
Authors: Lazarev P. О.
Published: September 2021

According to current international and national guidelines for the management of arterial hypertension preference is given to the use of fixed combinations of antihypertensive drugs of different classes, thus increasing the effectiveness of therapy acting in a complementary manner to affect different pathogenic mechanisms of arterial hypertension and reducing the frequency of side effects. A fixed combination of lercanidipine and enalapril contains antihypertensive drugs that have complementary mechanisms of action. This combination effectively reduces blood pressure, has high efficacy and tolerability, it may provide an additive effect on macro- and microvascular structures, arterial stiffness and oxidative stress. It has a beneficial influence on renal function, especially in patients with comorbidities.
Asthenic syndrome: new challenges – a new approach
Authors: Barna O. M. , Kalinichenko M. A.
Published: September 2021

Today, asthenia is one of the most common syndromes in the practice of a doctor of any specialty. Her treatment uses a comprehensive approach that includes physical training, psychotherapy, diet and pharmacotherapy. Pharmacotherapeutic treatment of asthenia includes the appointment of antidepressants, nootropics, tranquilizers, psychostimulants, neuroleptics. Given the multimodality and multilevel nature of the lesion of the nervous system in CОVID-19, in the recovery period, it is advisable to prescribe complex drugs with a wide range of therapeutic possibilities. The use of herbal drugs, in particular Vazavital Neuro and Cardiolin, is considered promising.
COVID-19 and heart
Authors: Tseluyko V. Y.
Published: September 2021

The coronavirus pandemic has significantly affected the risk of developing and the clinical course of cardiovascular disease. The article considers in detail the main provisions of the effect of coronavirus on the cardiovascular system and the peculiarities of the management of patients with certain diseases of the cardiovascular system. The injuries can be divided into several variants: myocarditis, myocardial ischemia associated with impaired blood supply, against the background of both atherosclerotic and intact arteries, myocardial changes as a result of endothelium, and, finally, a combination of different mechanisms.
Cleaning Images with Gaussian Process Regression
Authors: Zhang Hengyue , Brandt Timothy D.
Published: September 2021

Many approaches to astronomical data reduction and analysis cannot tolerate missing data: corrupted pixels must first have their values imputed. This paper presents astrofix, a robust and flexible image imputation algorithm based on Gaussian process regression. Through an optimization process, astrofix chooses and applies a different interpolation kernel to each image, using a training set extracted automatically from that image. It naturally handles clusters of bad pixels and image edges and adapts to various instruments and image types. For bright pixels, the mean absolute error of astrofix is several times smaller than that of median replacement and interpolation by a Gaussian kernel. We demonstrate good performance on both imaging and spectroscopic data, including the SBIG 6303 0.4 m telescope and the FLOYDS spectrograph of Las Cumbres Observatory and the CHARIS integral-field spectrograph on the Subaru Telescope.
Prior Probability Distributions of Neutron Star Crust Models
Authors: Balliet Lauren E. , Newton William G. , Cantu Sarah , Budimir Srdan
Published: September 2021

To make best use of multifaceted astronomical and nuclear data sets, probability distributions of neutron star models that can be used to propagate errors consistently from one domain to another are required. We take steps toward a consistent model for this purpose, highlight where model inconsistencies occur, and assess the resulting model uncertainty. Using two distributions of nuclear symmetry energy parameters—one uniform, the other based on pure neutron matter theory—we prepare two ensembles of neutron star inner crust models. We use an extended Skyrme energy density functional within a compressible liquid drop model (CLDM). We fit the surface parameters of the CLDM to quantum 3D Hartree–Fock calculations of crustal nuclei. All models predict that more than 50% of the crust by mass and 15% of the crust by thickness comprises pasta with medians of around 62% and 30%, respectively. We also present 68% and 95% ranges for the crust composition as a function of density. We examine the relationships between crust–core boundary and pasta transition properties, the thickness of the pasta layers, the symmetry energy at saturation and subsaturation densities, and the neutron skins of 208Pb and 48Ca. We quantify the correlations using the maximal information coefficient, which can effectively characterize nonlinear relationships. Future measurements of neutron skins, information from nuclear masses and giant resonances, and theoretical constraints on PNM will be able to place constraints on the location of the pasta and crust–core boundaries and the amount of pasta in the crust.
Detection of Exposure to Microplastics in Humans: A Systematic Review
Authors: Basri K Sarinah , Daud Anwar , Astuti Ratna Dwi Puji , K Basri
Published: September 2021

BACKGROUND: Microplastics are able to enter the human body through food chains, personal care products, contact (skin) from the soil, water or inhalation of microplastics in the air.

AIM: This article aims to identify the presence of microplastics that are exposed to humans.

METHODS: Systematic review using four bibliographic databases (Google Scholar, Wiley Online Library, PubMed, and Science Direct). Literature search from 2016 to 2021, in the search found as many as 10983 papers extracted using PRISMA guidelines, a total of five papers were selected for review.

RESULTS: In this review article, the presence of oral, dermal, and inhalation exposed microplastics is found in feces, colon, placenta, scalp hair, hand skin, facial skin, and saliva. Several methods are used to identify microplastics according to polymer types, shape, and sizes microplastics in humans. The polymer type often found in the article is polypropylene. In addition, fibers, fragments and films are detectable shape of microplastic, while the size of microplastics >5 mm.

CONCLUSION: This literature study provides evidence that microplastics of various types of polymers, shapes and sizes are ubiquitous in humans. Hence, the possibility of health risks resulting from microplastic exposure in the human body should not be ignored.
A candiru, Paracanthopoma sp. (Siluriformes: Trichomycteridae), associated with a thorny catfish, Doras phlyzakion (Siluriformes: Doradidae), in a tributary of the middle Rio Negro, Brazilian Amazon
Authors: Lubich Chiara C. F. , Martins André R. , Freitas Carlos E. C. , Hurd Lawrence E. , Siqueira-Souza Flávia K.
Published: September 2021

Amazonian vampire catfish, known regionally as “candiru”, are recognized as hematophagous fishes, but information on their ecology remains limited. We provide the first report of Paracanthopoma sp. (Vandelliinae) found attached to the body surface of a thorny catfish, Doras phlyzakion Sabaj Pérez et Birindelli, 2008, bellow the lateral bony plates, rather than at the gills where they have usually been found. The specimens had not recently ingested blood or other identifiable fish remains (flesh, skin, or mucus), which could be an indication they have been using this host for protection or as a phoretic association, rather than for feeding. Thus, the interaction of vampire fish with the host catfish may be more complex than previously understood.
Length–weight relations of 11 goby species (Actinopterygii: Gobiiformes) from mangroves along the Ba Lat estuary of the Red River, Vietnam
Authors: Tran Hau Duc , Nguyen Anh Thi , Chu Nam Hoang , Nguyen Trang Thi Huyen , Ta Thuy Thi , Nguyen Hung Phuc , Pham Long Van , Ha Linh Manh
Published: September 2021

Presently reported study examined the length–weight relations for 11 goby species collected from a mangrove estuary of the Red River, Vietnam. A total of 1097 individuals of the following species, representing three goby families, were analyzed: Butis butis (Hamilton, 1822); Butis koilomatodon (Bleeker, 1849); Acentrogobius moloanus (Herre, 1927); Acentrogobius viridipunctatus (Valenciennes, 1837); Apocryptodon madurensis (Bleeker, 1849); Aulopareia unicolor (Valenciennes, 1837); Glossogobius giuris (Hamilton, 1822); Gobiopsis macrostoma Steindachner, 1861; Mugilogobius abei (Jordan et Snyder, 1901); Tridentiger barbatus (Günther, 1861); and Tridentiger trigonocephalus (Gill, 1859). The regression slope values (b) ranged from 2.909 to 3.621. The majority of species had positive allometric or isometric growth pattern with b ≥ 3, except for only one species (G. giuris) which had a negative allometric growth with b = 2.909. This study provided the first LWR information of four gobies that have not been reported in FishBase yet. Besides, the reference for LWRs of other gobies at an ecologically important area like Ba Lat Estuary is also provided.
After four decades—Occurrence of the daggertooth pike conger, Muraenesox cinereus (Actinopterygii: Anguilliformes: Muraenesocidae), in the Mediterranean Sea
Authors: Irmak Erhan , Özden Uğur
Published: September 2021

In October 2020, a single specimen of the daggertooth pike conger, Muraenesox cinereus (Forsskål, 1775), was caught by longline at a depth of 120 m, from the Mediterranean coast of Turkey. This species has been recorded from the Mediterranean for the second time after approximately four decades. This new finding shows that the distribution of the species has expanded.
Length–weight relations of 14 fish species (Actinopterygii) from the Chalakudy River, Western Ghats, India
Authors: Renjithkumar Chelapurath Radhakrishnan , Roshni Kuttanelloor , Ranjeet Kutty
Published: September 2021

Length–weight relations of 14 fish species caught by small-scale fishery from the Chalakudy River of the Western Ghats biodiversity hotspot, India were analyzed from April 2018 to March 2019. The following species were studied: Amblypharyngodon microlepis (Bleeker, 1853); Dawkinsia filamentosa (Valenciennes, 1844); Puntius mahecola (Valenciennes, 1844); Osteobrama bakeri (Day, 1873); Labeo dussumieri (Valenciennes, 1842); Channa marulius (Hamilton, 1822); Channa striata (Bloch, 1793); Horabagrus brachysoma (Günther, 1864); Mystus armatus (Day, 1865); Pangasianodon hypophthalmus (Sauvage, 1878); Heteropneustes fossilis (Bloch, 1794); Etroplus suratensis (Bloch, 1790); Megalops cyprinoides (Broussonet, 1782); Parambassis thomassi (Day, 1870). The main fishing gear that was used in the data collection were gill nets, seine nets, and cast nets. The b values in the LWRs ranged from 2.649 (L. dussumieri) to 3.023 (P. hypophthalmus). This study reports the first LWR reference for five species and new maximum total lengths for five species. The results provide baseline information for the sustainable management and conservation of the studied species.