bluuebunny/crossref_metadata_2025 huggingface dataset:
Designing a Scale to Assess Dialectical Thinking: Link to ECERS-R Items
Authors: Veraksa Nikolay , Shiyan Olga , Sviridova Ekaterina
Published: December 2019

Dialectical thinking is gaining wide circulation as part of personal and social preschool child development in modern society, which makes all the more urgent the task of designing a tool to evaluate the extent to which the educational environment in a pre-school establishment supports the development of dialectical thinking in preschoolers. To implement this task, the researchers analyzed the ECERS-R as a means for assessing the quality of preschool education and concluded that this tool fails to focus on rating the environment in terms of the development of dialectical thinking. N.Ye. Veraksa and E.V. Sviridova designed a tool for assessing how well the educational environment supports dialectical thinking in preschoolers (the scale of dialectical thinking support (DTS scale). The research into the use of the DTS scale was conducted in 18 preparatory groups of three educational complexes in Moscow in February–April 2019. The comparison of the results on the DTS scale and those on the ECERS-R scale made it possible to conclude that the ECERS-R scale does not differentiate between the stimulation of dialectical thinking and formally logical thinking in preschool age children. The use of the newly designed tool was justified statistically. It is noted that the teacher activity in line with the ECERS-R scale scores of “Stimulating Communication with Children”, “Books and Illustrations”, “Using Speech to Develop Cognitive Skills” may be associated with decreased levels of support for children’s dialectical thinking in preschool educational institutions. In addition, a positive relationship was found to exist between the ECERS-R score of “Care-Giver and Children Interaction” and DTS scale. The results obtained make it possible to hypothesize that there are interrelations between the development of dialectic thinking in children, on the one hand, and voluntariness and the emotional sphere, on the other.
Experimental Research into Conscious Self-Regulation in First-Graders with Developmental Delay
Authors: Babkina Nataliya V.
Published: December 2019

The underdeveloped conscious self-regulation of actions plays a primary role in the disorder-related character of children with developmental delay (DD). This study aimed to analyze and systematize specific occurrences of conscious self-regulation in children’s DD-affected cognitive activity. Children aged 7–8 years were involved in the study (n = 60), including children with DD (n = 40) and school children displaying typical development (n = 20). The dotting test, visual pattern test, and Toulouse–Pieron attention test are the practical methods used in the study. Mathematical methods of statistics were applied to analyze the study outcome. The experimental research identified and described four levels of conscious self-regulation development in the cognitive activity of children with different learning capacities. The findings proved that children of 7–8 years with DD have an underdeveloped level of conscious self-regulation of actions in terms of their cognitive activity, and that they differ from their peers regarding typical development in terms of their conscious self-regulation level and skills. Special intervention programs that develop conscious self-regulation in the performance and behavior of children with DD are required to realize their cognitive and personal capacities and provide them with high-quality education.
Strategies of Speech Interaction between Adults and Preschool Children with Typical and Atypical Development
Authors: Lyakso Elena , Frolova Olga , Grigorev Aleksey , Gorodnyi Viktor , Nikolaev Aleksandr
Published: December 2019

The goal of this research is to study the speech strategies of adults’ interactions with 4–7-year-old children. The participants are “mother–child” dyads with typically developing (TD, n = 40) children, children with autism spectrum disorders (ASDs, n = 20), Down syndrome (DS, n = 10), and “experimenter–orphan” pairs (n = 20). Spectrographic, linguistic, phonetic, and perceptual analyses (n = 465 listeners) of children’s speech and mothers’ speech (MS) are executed. The analysis of audio records by listeners (n = 10) and the elements of nonverbal behavior on the basis of video records by experts (n = 5) are made. Differences in the speech behavior strategies of mothers during interactions with TD children, children with ASD, and children with DS are revealed. The different strategies of “mother–child” interactions depending on the severity of the child’s developmental disorders and the child’s age are described. The same features of MS addressed to TD children with low levels of speech formation are used in MS directed to children with atypical development. The acoustic features of MS correlated with a high level of TD child speech development do not lead to a similar correlation in dyads with ASD and DS children. The perceptual and phonetic features of the speech of children of all groups are described.
Study on the Photocathodic Protection of Q235 Steel by CdIn2S4 Sensitized TiO2 Composite in Splash Zone
Authors: Ma Zheng , Ma Xiumin , Wang Xiutong , Liu Nazhen , Liu Xuehui , Hou Baorong
Published: December 2019

In this work, the photo-catalytic activity of TiO2 is considerably enhanced via sensitization with CdIn2S4, and its application for protecting Q235 from corrosion in splash zones is examined. TiO2 nanotube arrays (NTAs) are prepared on a flat Ti substrate via two-step anodization. CdIn2S4 is deposited on the surface of TiO2 NTAs by hydrothermal reaction. TiO2 NTAs with enormous specific surface areas and large-diameter hollow nanostructures are found to benefit the immobilization of CdIn2S4. As a narrow band gap semiconductor, CdIn2S4 is able to extend the light absorption range of TiO2, and the construction of an n–n type hetero-junction accelerates the separation of carriers. Strong solar light, which accelerates the corrosion of Q235 in the splash zone area, is converted into the necessary condition for protecting Q235 from corrosion. In this work, TiO2 is sensitized with MoS2 microspheres (MoS2/TiO2 nanocomposites), which were prepared on a flat Ti substrate via a two-step anodization and hydrothermal method, sequentially.
The Role of NF-κB in Physiological Bone Development and Inflammatory Bone Diseases: Is NF-κB Inhibition “Killing Two Birds with One Stone”?
Authors: Jimi Eijiro , Takakura Nana , Hiura Fumitaka , Nakamura Ichiro , Hirata-Tsuchiya Shizu
Published: December 2019

Nuclear factor-κB (NF-κB) is a transcription factor that regulates the expression of various genes involved in inflammation and the immune response. The activation of NF-κB occurs via two pathways: inflammatory cytokines, such as TNF-α and IL-1β, activate the “classical pathway”, and cytokines involved in lymph node formation, such as CD40L, activate the “alternative pathway”. NF-κB1 (p50) and NF-κB2 (p52) double-knockout mice exhibited severe osteopetrosis due to the total lack of osteoclasts, suggesting that NF-κB activation is required for osteoclast differentiation. These results indicate that NF-κB may be a therapeutic target for inflammatory bone diseases, such as rheumatoid arthritis and periodontal disease. On the other hand, mice that express the dominant negative form of IκB kinase (IKK)-β specifically in osteoblasts exhibited increased bone mass, but there was no change in osteoclast numbers. Therefore, inhibition of NF-κB is thought to promote bone formation. Taken together, the inhibition of NF-κB leads to “killing two birds with one stone”: it suppresses bone resorption and promotes bone formation. This review describes the role of NF-κB in physiological bone metabolism, pathologic bone destruction, and bone regeneration.
STK3/4 Expression Is Regulated in Uterine Endometrial Cells during the Estrous Cycle
Authors: Moon Sohyeon , Lee Ok-Hee , Lee Sujin , Lee Jihyun , Park Haeun , Park Miseon , Chang Eun Mi , Park Keun-Hong , Choi Youngsok
Published: December 2019

The uterus is dynamically regulated in response to various signaling triggered by hormones during the estrous cycle. The Hippo signaling pathway is known as an important signaling for regulating cellular processes during development by balancing between cell growth and apoptosis. Serine/threonine protein kinase 3/4 (STK3/4) is a key component of the Hippo signaling network. However, the regulation of STK3/4-Hippo signaling in the uterus is little known. In this study, we investigated the regulation and expression of STK3/4 in the uterine endometrium during the estrous cycle. STK3/4 expression was dynamically regulated in the uterus during the estrous cycle. STK3/4 protein expression was gradually increased from the diestrus stage and reached the highest in the estrus stage. STK3/4 was exclusively localized in the luminal and glandular epithelial cells of the uterus, and phosphorylated STK3/4 was also increased at the estrus stage. Moreover, the increase of STK3/4 expression in uteri was induced by administration of estradiol, but not by progesterone injection in ovariectomized mice. Pretreatment with an estrogen receptor antagonist ICI 182,780 reduced estrogen-induced STK3/4 expression and its phosphorylation. The estrogen-induced STK3/4 expression was related to the increase in phosphorylation of downstream targets including LATS1/2 and YAP. These findings suggest that STK3/4-Hippo signaling acts a novel signaling pathway in the uterine epithelium and STK3/4-Hippo is one of key molecules for connecting between the estrogen downstream signaling pathway and the Hippo signaling pathway leading to regulate dynamic uterine epithelium during the estrous cycle.
Use of Sodium Bicarbonate During Pediatric Cardiac Admissions with Cardiac Arrest: Who Gets It and What Does It Do?
Authors: Loomba Rohit S. , Ahmed Mubbasheer , Abdulkarim Mubeena , Villarreal Enrique G. , Flores Saul
Published: December 2019

The objectives of this study were to characterize the use of sodium bicarbonate in pediatric cardiac admissions that experience cardiac arrest, to determine sodium bicarbonate use over the years, and to determine the impact of sodium bicarbonate on length of admissions, billed charges, and inpatient mortality. A cross-sectional study was conducted utilizing the Pediatric Health Information System database. Characteristics of admissions with and without sodium bicarbonate were initially compared by univariate analyses. The frequency by which sodium bicarbonate was used was compared by year. Regression analyses were conducted to determine the impact of sodium bicarbonate on length of stay, billed charges, and inpatient mortality. A total of 3987 (50.3%) of pediatric cardiac intensive care admissions with cardiac arrest utilized sodium bicarbonate; however, frequency changed from 62.1% in 2004 to 43.7% in 2015. Linear regression analysis demonstrated a decrease in length of stay (−27.5 days, p < 0.01) and billed charges (−$470,906, p < 0.01). Logistic regression analysis demonstrated an increase in mortality (odds ratio 1.77, 95% confidence interval 1.56–2.01). In conclusion, sodium bicarbonate is being used with less frequency over the last years in pediatric cardiac admissions with cardiac arrest. After adjustment for cardiac diagnoses, comorbidities, vasoactive medications, and other resuscitation medications, sodium bicarbonate is independently associated with increased mortality.
Influence of Different Heat Treatment Temperatures on the Microstructure, Corrosion, and Mechanical Properties Behavior of Fe-Based Amorphous/Nanocrystalline Coatings
Authors: Liu Shenglin , Zhu Yongsheng , Lai Xinyue , Zheng Xueping , Jia Runnan , Yuan Xiangsheng
Published: December 2019

Fe-based amorphous/nanocrystalline coatings with smooth, compact interior structure and low porosity were fabricated via supersonic plasma spraying (SPS). The coatings showed outstanding corrosion resistance in a 3.5% NaCl solution at room temperature. In order to analyze the effect of annealing treatment on the microstructure, corrosion resistance and microhardness, the as-sprayed coating was annealed for 1 h under different temperatures such as 350, 450, 550 and 650 °C, respectively. The results showed that the number of oxides and cracks in the coatings presented an obvious increase with increasing annealing temperature, and the corrosion resistance of the coatings showed an obvious reduction. However, the microhardness of coatings showed an important increase. The microhardness of the coating could reach 1018 HV when the heat treatment temperature reached 650 °C. The X-ray diffraction (XRD) results showed that there appeared a number of crystalline phases in the coating when the heat treatment temperature was at 650 °C. The crystalline phases led to the increase of the microhardness.
Challenges for Teaching Wireless Communications Standards at the Graduate Level
Authors: Pierucci Laura
Published: December 2019

Telecom operators and companies ask for graduates with a specific education on the standards of the Institute of Electrical and Electronic Engineers (IEEE) or the 3rd Generation Partnership Project (3GPP), and the University curricula must consider these needs. The standards are written in a technical form, in a language understandable only by experts, and the technical details and algorithms are not often outlined. Therefore, a new educational methodology must be applied because the teachers have to bridge the gap between the basic knowledge (and the poor technical language) of students and the technical specifics of the standards. The paper presents a structured methodology to provide innovative teaching of the wireless standards for the Engineering Master’s degree, according to the Conceive, Design, Implement, and Operate (CDIO) initiative and project based learning. The methodology is organized in three learning phases to understand the standardization process and improve students’ skills to implement standard compliant communications systems. This challenge can be only won with laboratory activities to assist students in understanding wireless standards and with hands-on experiences during the internship period at telecom operators with the vision of a close cooperation between universities and telecom operators. Only in this way can the students achieve a solid background in designing and developing prototypes compliant with wireless communications standards and working skills for their future professional engineering careers. The effectiveness of the adopted educational methodology to provide innovative learning of wireless standards is evaluated by questionnaires filled in online by students and by the achieved skills implemented as confirmed by telecom operators. In this vision, the paper provides decision support to leaders in educational organizations to teach wireless standards effectively.
Teacher Attrition: Differences in Stakeholder Perceptions of Teacher Work Conditions
Authors: Harris Scott P. , Davies Randall S. , Christensen Steven S. , Hanks Joseph , Bowles Bryan
Published: December 2019

The purpose of this study was to identify differences in perceptions between three stakeholder groups—principals, K-12 teachers, and parents—regarding the effect of workplace conditions on teacher attrition. All three groups agreed that workplace conditions are important, but they disagreed about (a) which workplace conditions are most problematic for teachers, (b) the magnitude of these problems, and (c) the degree to which these problems may contribute to teachers leaving. The greatest disagreements occurred in perceptions of (a) teachers’ involvement in decision-making, (b) protection of teacher preparation time, (c) administration’s management of student discipline, (d) adequacy of resource availability, (e) the degree to which a trusting and supportive school environment existed within the school, and (f) whether teachers’ expectations were reasonable. Overall, principals believed that work conditions are relatively good for teachers, while many teachers disagreed with these perceptions.
A Novel Video Face Verification Algorithm Based on TPLBP and the 3D Siamese-CNN
Authors: Wang Yu , Ma Shuyang , Shen Xuanjing
Published: December 2019

In order to reduce the computational consumption of the training and the testing phases of video face recognition methods based on a global statistical method and a deep learning network, a novel video face verification algorithm based on a three-patch local binary pattern (TPLBP) and the 3D Siamese convolutional neural network is proposed in this paper. The proposed method takes the TPLBP texture feature which has excellent performance in face analysis as the input of the network. In order to extract the inter-frame information of the video, the texture feature maps of the multi-frames are stacked, and then a shallow Siamese 3D convolutional neural network is used to realize dimension reduction. The similarity of high-level features of the video pair is solved by the shallow Siamese 3D convolutional neural network, and then mapped to the interval of 0 to 1 by linear transformation. The classification result can be obtained with the threshold of 0.5. Through an experiment on the YouTube Face database, the proposed algorithm got higher accuracy with less computational consumption than baseline methods and deep learning methods.
A Smart IoT Device for Detecting and Responding to Earthquakes
Authors: Lee Jangsoo , Khan Irshad , Choi Seonhwa , Kwon Young-Woo
Published: December 2019

The advancement of hardware and software technologies makes it possible to use smartphones or Internet of things for monitoring environments in realtime. In recent years, much effort has been made to develop a smartphone based earthquake early warning system, where low-cost acceleration sensors inside a smartphones are used for capturing earthquake signals. However, because a smartphone comes with a powerful CPU, spacious memory, and several sensors, it is waste of such resources to use it only for detecting earthquakes. Furthermore, because a smartphone is mostly in use during the daytime, the acquired data cannot be used for detecting earthquakes due to human activities. Therefore, in this article, we introduce a stand-alone device equipped with a low-cost acceleration sensor and least computing resources to detect earthquakes. To that end, we first select an appropriate acceleration sensor by assessing the performance and accuracy of four different sensors. Then, we design and develop an earthquake alert device. To detect earthquakes, we employ a simple machine learning technique which trains an earthquake detection model with daily motions, noise data recorded in buildings, and earthquakes recorded in the past. Furthermore, we evaluate the four acceleration sensors by recording two realistic earthquakes on a shake-table. In the experiments, the results show that the developed earthquake alert device can successfully detect earthquakes and send a warning message to nearby devices, thereby enabling proactive responses to earthquakes.
Temperature and Rainfall Are Separate Agents of Selection Shaping Population Differentiation in a Forest Tree
Authors: Costa e Silva João , Potts Brad , Harrison Peter A. , Bailey Tanya
Published: December 2019

Research highlights: We present evidence indicating that covariation of functional traits among populations of a forest tree is not due to genetic constraints, but rather selective covariance arising from local adaptation to different facets of the climate, namely rainfall and temperature. Background and Aims: Traits frequently covary among natural populations. Such covariation can be caused by pleiotropy and/or linkage disequilibrium, but also may arise when the traits are genetically independent as a direct consequence of natural selection, drift, mutation and/or gene flow. Of particular interest are cases of selective covariance, where natural selection directly generates among-population covariance in a set of genetically independent traits. We here studied the causes of population-level covariation in two key traits in the Australian tree Eucalyptus pauciflora. Materials and Methods: We studied covariation in seedling lignotuber size and vegetative juvenility using 37 populations sampled from throughout the geographic and ecological ranges of E. pauciflora on the island of Tasmania. We integrated evidence from multiple sources: (i) comparison of patterns of trait covariation within and among populations; (ii) climate-trait modelling using machine-learning algorithms; and (iii) selection analysis linking trait variation to field growth in an arid environment. Results: We showed strong covariation among populations compared with the weak genetic correlation within populations for the focal traits. Population differentiation in these genetically independent traits was correlated with different home-site climate variables (lignotuber size with temperature; vegetative juvenility with rainfall), which spatially covaried. The role of selection in shaping the population differentiation in lignotuber size was supported by its relationship with fitness measured in the field. Conclusions: Our study highlights the multi-trait nature of adaptation likely to occur as tree species respond to spatial and temporal changes in climate.
Characterization of Nutritional, Physicochemical, and Phytochemical Composition and Antioxidant Capacity of Three Strawberry “Fragaria × ananassa Duch.” Cultivars (“Primoris”, “Endurance”, and “Portola”) from Western Region of Portugal
Authors: Ganhão Rui , Pinheiro Joaquina , Tino Clara , Faria Hugo , Gil Maria M.
Published: December 2019

In this study, nutritional composition (protein, lipids, carbohydrates, ash, and moisture), physicochemical properties (soluble solid content, titratable acidity, texture and instrumental colour on surface, and internal section), phytochemicals (total phenolic content and anthocyanin content), and antioxidant capacity (DPPH—2,2′-diphenyl-1-picrylhydrazyl radical scavenging capacity and ferric-reducing antioxidant power) of three strawberry (Fragaria × ananassa Duch.) cultivars (cv. “Primoris”, cv. “Endurance”, and cv. “Portola”) produced in the western region of Portugal (Caldas da Rainha) were evaluated. From the obtained, results no significant differences (P > 0.05) in nutritional composition were detected in all of the cultivars; with the exception of lower protein content observed in cv. “Portola” (0.57 g/100 g ± 0.04; P < 0.05). Regarding the a* value of whole strawberry fruits, no significant differences (P > 0.05) were found in any of the cultivars, which revealed a similar redness. The cv. “Endurance” revealed the highest bioactivity content compared to the other cultivars. Overall, these results provide important information about the high quality of strawberry produced in the western region of Portugal and may be used as a tool for adding value to a functional food in the Mediterranean diet due to the phytochemical composition and nutritional value of strawberry fruits
Hydrolysis of Whey Protein-Dextran Glycates Made Using the Maillard Reaction
Authors: Li Na , Etzel Mark R.
Published: December 2019

Protein-polysaccharide glycates are food ingredients that use the Maillard reaction to form a Schiff base linkage between the carbonyl of a polysaccharide and the free amino moiety of a protein. Glycates are excellent emulsification, foaming, and gelling agents in foods and improve protein solubility and heat stability. The present work examined if glycates dissociate by hydrolysis, returning to free un-glycated protein and dextran due to the reversibility of the Schiff base linkage. Hydrolysis of glycates made from whey protein isolate and dextran was measured versus time and temperature, allowing determination of the rate constants and equilibrium constants for glycate hydrolysis. Glycates underwent hydrolysis when placed into aqueous solutions at common food processing temperatures. For example, during hot food storage (60 °C), equilibrium fractional hydrolysis was 44%, whereas at ambient temperature (22 °C), it was 8%. The present work aims to increase the successful use of glycates in new foods by knowing what foods and conditions avoid glycate hydrolysis.
Cancer Diagnosis Disclosure and Quality of Life in Elderly Cancer Patients
Authors: Zheng Ying , Lei Fang , Liu Bao
Published: December 2019

Informed consent and patient autonomy rights require an optimal cancer diagnosis disclosure strategy to be used to update the patients and caregivers with the bad news. However, a cancer diagnosis disclosure may arouse anxiety and distress which increase patients’ and caregivers’ psychological burden. This study aims to explore the influence of cancer diagnosis disclosure on the quality of life in elderly cancer patients and their caregivers, and to introduce an effective way to disclose cancer diagnosis. A total of 120 participants were randomly selected in the study. The Medical Coping Modes Questionnaire was used to select informed person. The SPIKES was used to guide the disclosure procedures. The informed patients’ or caregivers’ quality of life were evaluated by the Generic Quality of Life Inventory-74 or Caregiver Quality of Life Scale before and after the cancer diagnosis disclosure and at the discharge time. After cancer diagnosis disclosure, no significant change was found on the quality of life of the informed person. With multiple psychological interventions implemented, a significant increase was noticed on the quality of life of the informed person. Applying the cancer diagnosis disclosure strategies and psychological intervention were essential to improve cancer patients’ and caregivers’ quality of life.
Mesenchymal Stem/Stromal Cell Production Compliant with Good Manufacturing Practice: Comparison between Bone Marrow, the Gold Standard Adult Source, and Wharton’s Jelly, an Extraembryonic Source
Authors: Laroye Caroline , Gauthier Mélanie , Antonot Hélène , Decot Véronique , Reppel Loïc , Bensoussan Danièle
Published: December 2019

Many clinical trials report mesenchymal stem/stromal cells (MSCs) efficacy in various indications. Therefore, standardization of MSC production becomes necessary. MSC properties are impacted by tissue origin, especially if they are from extraembryonic tissue or adult sources. For this reason, we evaluated the impact of MSC tissue origin on production. Methods: Three productions of MSC from Wharton’s Jelly (WJ) or from bone marrow (BM) were performed according to good manufacturing practice. The identity (phenotype, differentiation, and clonogenic capacities), safety (karyotype, telomerase activity, sterility, and donor qualification), and functionality (viability, mixed lymphocyte reaction) of each cell batch were analyzed. Results: Slight differences between MSC sources were observed for phenotype, telomerase activity, and clonogenic capacities. Conclusion: Both sources have made it possible to quickly and easily obtain clinical grade MSC. However, as availability of the source is thought to be essential, WJ seems more advantageous than BM.
Aortic Valvular Disease in Elderly Subjects with Heterozygous Familial Hypercholesterolemia: Impact of Lipid-Lowering Therapy
Authors: Marco-Benedí Victoria , Laclaustra Martin , Casado-Dominguez Juan M. , Villa-Pobo Rosa , Mateo-Gallego Rocío , Sánchez-Hernández Rosa M. , Blanco Nuez Marta , Ortega-Martínez de Victoria Emilio , Sitges Marta , Pedro-Botet Juan , Puzo Jose , Villarroel Teresa , Civeira Fernando
Published: December 2019

Hypercholesterolemia and statins are risk factors for aortic stenosis (AS) and vascular calcification, respectively. Whether heterozygous subjects with familial hypercholesterolemia (HeFH) treated with statins are at risk of AS is unknown. We study the prevalence of AS, aortic valve calcification (AoVC), and aortic sclerosis (ASc) in elderly subjects with HeFH in a prolonged statin treatment. Case-control study, cases were adults ≥65 years of age with a genetic diagnosis of HeFH, LDLc >220 mg/dl, and statin treatment ≥5 years. Controls were relatives of HeFH patients, with LDLc <190 mg/dl. Participants underwent a cardiac ultrasound for aortic valve analysis. We studied 205 subjects, 112 HeFH and 93 controls, with mean age 71.8(6.5) years and 70.0(7.3) years, respectively. HeHF, with respect to controls, presented greater gradients of aortic transvalvular pressure, 7.4(7.3) mmHg versus 5.0(2.8) mmHg, and maximum aortic velocity, 1.7(0.7) m/s versus 1.5(0.4) m/s, and lower aortic valve opening area, 2.0(0.7) cm2 versus 2.4(0.6) cm2 (all p < 0.05). AoVC and ASc were also more prevalent in HeFH (p < 0.05 between groups). Moderate/severe AS prevalence was higher among HeFH: 7.1% versus 1.1% (age- and sex-adjusted odds ratio (OR) 8.33, p = 0.03). Independent risk factors for aortic valve disease in HeFH were age and LDLc before treatment. The number of years under statin treatment was not associated with any aortic valve measurement. Subjects ≥65 years with HeFH in prolonged statin treatment show more aortic valvular disease and higher frequency of AS than controls. Life-long elevated LDLc exposure, rather than time of exposure to statins, explains this higher risk.
1,25(OH)2D3 Differently Affects Immunomodulatory Activities of Mesenchymal Stem Cells Depending on the Presence of TNF-α, IL-1β and IFN-γ
Authors: Behm Christian , Blufstein Alice , Gahn Johannes , Kubin Barbara , Nemec Michael , Moritz Andreas , Rausch-Fan Xiaohui , Andrukhov Oleh
Published: December 2019

Periodontal ligament-derived mesenchymal stem cells (hPDLSCs) possess immunomodulatory abilities which are strongly enhanced by various inflammatory cytokines. Vitamin D3 has anti-inflammatory effects on hPDLSCs and immune cells. However, no study to date has directly compared the influence of 1,25(OH)2D3 on the immunomodulatory activities of hPDLSCs in the presence of different cytokines. In the present study, the effects of hPDLSCs treated with tumor necrosis factor (TNF)-α, interleukin (IL)-1β, or interferon (IFN)-γ in the presence of 1,25(OH)2D3 on the proliferation of allogenic CD4+ T lymphocyte or on the functional status of primary CD68+ macrophages were analyzed in coculture models. Additionally, the effects of 1,25(OH)2D3 on TNF-α-, IL-1β-, and IFN-γ-induced gene expression of some immunomodulatory factors in hPDLSCs were compared. Under coculture conditions, 1,25(OH)2D3 increased or decreased CD4+ T lymphocyte proliferation via hPDLSCs, depending on the cytokine. hPDLSCs primed with 1,25(OH)2D3 and different cytokines affected pro- and anti-inflammatory cytokine expression in macrophages variably, depending on the priming cytokine. With one exception, 1,25(OH)2D3 significantly reduced TNF-α-, IL-1β-, and IFN-γ-induced expression of all the investigated immunomediators in hPDLSCs, albeit to different extents. These results suggest that 1,25(OH)2D3 influences the immunomodulatory activities of hPDLSCs depending qualitatively and quantitatively on the presence of certain inflammatory cytokines.
Type 2 Diabetes Mellitus and Altered Immune System Leading to Susceptibility to Pathogens, Especially Mycobacterium tuberculosis
Authors: Ferlita Steve , Yegiazaryan Aram , Noori Navid , Lal Gagandeep , Nguyen Timothy , To Kimberly , Venketaraman Vishwanath
Published: December 2019

There has been an alarming increase in the incidence of Type 2 Diabetes Mellitus (T2DM) worldwide. Uncontrolled T2DM can lead to alterations in the immune system, increasing the risk of susceptibility to infections such as Mycobacterium tuberculosis (M. tb). Altered immune responses could be attributed to factors such as the elevated glucose concentration, leading to the production of Advanced Glycation End products (AGE) and the constant inflammation, associated with T2DM. This production of AGE leads to the generation of reactive oxygen species (ROS), the use of the reduced form of nicotinamide adenine dinucleotide phosphate (NADPH) via the Polyol pathway, and overall diminished levels of glutathione (GSH) and GSH-producing enzymes in T2DM patients, which alters the cytokine profile and changes the immune responses within these patients. Thus, an understanding of the intricate pathways responsible for the pathogenesis and complications in T2DM, and the development of strategies to enhance the immune system, are both urgently needed to prevent co-infections and co-morbidities in individuals with T2DM.
Designed Conducting Polymer Composites That Facilitate Long-Lived, Light-Driven Oxygen and Hydrogen Evolution from Water in a Photoelectrochemical Concentration Cell (PECC)
Authors: Alsultan Mohammed , Zainulabdeen Khalid , Wagner Pawel , Swiegers Gerhard F. , Warren Holly
Published: December 2019

Light-driven water-splitting to generate hydrogen and oxygen from water is typically carried out in an electrochemical cell with an external voltage greater than 1.23 V applied between the electrodes. In this work, we examined the use of a concentration/chemical bias as a means of facilitating water-splitting under light illumination without the need for such an externally applied voltage. Such a concentration bias was created by employing a pH differential in the liquid electrolytes within the O2-generating anode half-cell and the H2-generating cathode half-cell. A novel, stretchable, highly ion-conductive polyacrylamide CsCl hydrogel was developed to connect the two half-cells. The key feature of the cell was the half-cell electrodes, which comprised thin-film conducting polymer composites that were previously designed to maximize light-driven catalysis at moderate pH. Upon being connected with the hydrogel in the presence of light irradiation (0.25 sun intensity on each electrode), the half-cells spontaneously produced hydrogen and oxygen from water, without the need for an externally applied voltage bias greater than 1.23 V. The cell operated reliably and efficiently for 14 h of continuous testing. These results demonstrate the fundamental feasibility of light-driven water-splitting in a photoelectrochemical concentration cell when employing electrodes that operate efficiently at moderate pH, even with low levels of light illumination. The designed conducting polymer composites proved ideal in that regard.
Economic Value of Cultural Ecosystem Services from Recreation in Popa Mountain National Park, Myanmar: A Comparison of Two Rapid Valuation Techniques
Authors: Soe Zin Wai , Suzuki Aya , Peh Kelvin S.-H. , Gasparatos Alexandros
Published: December 2019

Protected areas offer diverse ecosystem services, including cultural services related to recreation, which contribute manifold to human wellbeing and the economy. However, multiple pressures from other human activities often compromise ecosystem service delivery from protected areas. It is thus fundamental for effective management to understand the recreational values and visitor behaviors in such areas. This paper undertakes a rapid assessment of the economic value of cultural ecosystem services related to recreation in a national park in Myanmar using two valuation techniques, the individual travel cost method (TCM) and the Toolkit for Ecosystem Service Site-based Assessment (TESSA v.1.2). We focus on the Popa Mountain National Park, a protected area visited by approximately 800,000 domestic and 25,000 international tourists annually. Individual TCM estimates that each domestic visitor spent USD 20–24 per trip, and the total annual recreational value contributed by these visitors was estimated at USD 16.1–19.6 million (USD 916–1111 ha−1). TESSA estimated the annual recreational expenditure from domestic and international visitors at USD 15.1 million (USD 858 ha−1) and USD 5.04 million (USD 286 ha−1), respectively. Both methods may be employed as practical approaches to assess the recreational values of protected areas (and other land uses with recreational value), and they have rather complementary approaches. We recommend that both techniques be combined into a single survey protocol.
Amman (City of Waters); Policy, Land Use, and Character Changes
Authors: Gharaibeh Anne A. , Al.Zu’bi Esra’a M. , Abuhassan Lama B.
Published: December 2019

The character of Amman, Jordan, as the "City of Waters"—referring to the abundance of water flowing in its known stream—has faded away because of the municipal policy to cover the stream in the 1960s which gradually changed the ecological character. This paper traces and explores the impacts of stream-coverage policy on the city character, morphology and land use changes. The purpose is to understand how an engineered problem-solving policy changed physical and perceptive factors and affected the character of the city. It also explores future attitudes towards reversing the non-nature-friendly conditions. The methods depend upon monitoring morphological changes in aerial photographs and in land use maps from municipality archives, conducting interviews with the elderly who witnessed change, one-to-one questionnaires with stakeholders and online questionnaires with residents and visitors. The results show that covering the stream is depriving the city of its historical/ecological character. The policy failed to promote affluent business, to mitigate flood impacts, or to decrease traffic congestion in the Central Business District (CBD). Most age groups believe the stream can improve the image and economy, despite the fact of their unawareness of its historical presence. In conclusion, engineered problem-solving should not stay in the hands of decision makers (technocrats) alone, but rather be considered with the public, sustainable character experts, and ecologists.
Simulation of an Urban-Rural Spatial Structure on the Basis of Green Infrastructure Assessment: The Case of Harbin, China
Authors: Guo Rong , Bai Yujing
Published: December 2019

Due to their long-term dual structures and rapid urbanization, cities and villages in developing countries are undergoing the challenges of urban-rural integration and ecological security. This study aims to determine the pattern of urban-rural spatial structures under the circumstances of ecological security in the future to promote the integrated, coordinated, green, and sustainable development of urban-rural spaces. Using a quantitative evaluation method, the logistic-CA model, the LCP (least cost path) model, and a classification of ecological importance, this study constructed an integrated simulation model based on a green infrastructure assessment and applied the model to simulate and predict the urban-rural spatial structure of the Harbin city territory (Harbin) in 2035. The results indicate that the urban-rural hierarchical scale structure of Harbin comprises a central city, sub-central city, central town, major town, common town, central village, and general village. The urban-rural traffic network structure forms a pattern of “radiation + grid”, with Harbin city at the center of the structure. The urban-rural land use zoning structure consists of eco-spaces, agricultural spaces, and construction spaces. It can be concluded that in 2035, the urban-rural spatial structure of Harbin will show an increasing development tendency, where single-center, medium, and small cities in will Harbin develop, and traffic systems above the county level will also improve.
On the Study of Fixed Points for a New Class of α-Admissible Mappings
Authors: Darwish Mohamed Abdalla , Jleli Mohamed , O’Regan Donal , Samet Bessem
Published: December 2019

In this paper, we discuss the existence of fixed points for new classes of mappings. Some examples are presented to illustrate our results.
Exploring the Link between Academic Dishonesty and Economic Delinquency: A Partial Least Squares Path Modeling Approach
Authors: Druică Elena , Vâlsan Călin , Ianole-Călin Rodica , Mihail-Papuc Răzvan , Munteanu Irena
Published: December 2019

This paper advances the study of the relationship between the attitude towards academic dishonesty and other types of dishonest and even fraudulent behavior, such as tax evasion and piracy. It proposes a model in which the attitudes towards two types of cheating and fraud are systematically analyzed in connection with a complex set of latent construct determinants and control variables. It attempts to predict the tolerance towards tax evasion and social insurance fraud and piracy, using academic cheating as the main predictor. The proposed model surveys 504 student respondents, uses a partial least squares—path modeling analysis, and employs two subsets of latent constructs to account for context and disposition. The relationship between the outcome variable and the subset of predictors that account for context is mediated by yet another latent construct—Preoccupation about Money—that has been shown to strongly influence people’s attitude towards a whole range of social and economic behaviors. The results show academic dishonesty is a statistically significant predictor of an entire range of unethical and fraudulent behavior acceptance, and confirm the role played by both contextual and dispositional variables; moreover, they show that dispositional and contextual variables tend to be segregated according to how they impact the outcome. They also show that money priming does not act as a mediator, in spite of its stand-alone impact on the outcome variables. The most important result, however, is that the effect size of the main predictor is large. The contribution of this paper is two-fold: it advances a line of research previously sidestepped, and it proposes a comprehensive and robust model with a view to establish a hierarchy of significance and effect size in predicting deviance and fraud. Most of all, this research highlights the central role played by academic dishonesty in predicting the acceptance of any type of dishonest behavior, be it in the workplace, at home, or when discharging one’s responsibilities as a citizen. The results presented here give important clues as to where to start intervening in order to discourage the acceptance of deviance and fraud. Educators, university professors, and academic administrators should be at the forefront of targeted campaigns and policies aimed at fighting and reducing academic dishonesty.
Evaluation of Microstructures and Mechanical Properties of Sn-10Sb-Ni Lead-Free Solder Alloys with Small Amount of Ni Using Miniature Size Specimens
Authors: Kobayashi Tatsuya , Shohji Ikuo
Published: December 2019

Sn-Sb-Ni solder alloy is expected to be used as a die-attach material for a next-generation power semiconductors in power module. The aim of this paper is to investigate the effects of the Ni content on microstructures, tensile, and fatigue properties of Sn-10Sb-xNi (x = 0.05, 0.10, 0.25, 0.50) (mass%) lead-free solder alloys using miniature size specimens. The Sn-10Sb-Ni solder alloys have the microstructure in which Sb-Sn and Ni-Sb compounds are dispersed in the β-Sn matrix. As the Sb and Ni content increases, Sb-Sn and Ni-Sb compounds are coarsened, respectively. The effect of the Ni content on tensile properties of the alloy is slight at 25 °C. At 150 °C and 200 °C, 0.1% proof stress and tensile strength increase gradually with the Ni content increases, and saturate at the Ni amount over 0.25 mass%. According to the fatigue test at 200 °C, the fatigue properties of Sn-10Sb-Ni with 0.10–0.25 mass% Ni are better than that of the Sn-10Sb. From the experimental results, Sn-10Sb-Ni with 0.10–0.25 mass% Ni have superior mechanical properties.
Editorial for the Special Issue: Foodborne Pathogen Distribution, Ecology, Inactivation, and Methods of Differentiation
Authors: Beier Ross C. , Foley Steven L. , Harvey Roger B.
Published: December 2019

Foodborne pathogens are a major cause of diarrheal disease throughout the world, and 40% of the foodborne illnesses are observed among children under the age of 5 years [...]
Application of the Discrete Element Method to Study the Effects of Stream Characteristics on Screening Performance
Authors: Davoodi Ali , Asbjörnsson Gauti , Hulthén Erik , Evertsson Magnus
Published: December 2019

Screening is a key operation in a crushing plant that ensures adequate product quality of aggregates in mineral processing. The screening process can be divided into the two sub-processes of stratification and passage. The stratification process is affected by the relative difference between various properties, such as particle shape, size distribution, and material density. The discrete element method (DEM) is a suitable method for analyzing the interactions between individual particles and between particles and a screen deck in a controlled environment. The main benefit of using the DEM for simulating the screening process is that this method enables the tracking of individual particles in the material flow, and all of the collisions between particles and between particles and boundaries. This paper presents how different particle densities and flowrates affect material stratification and, in turn, the screening performance. The results of this study show that higher density particles have a higher probability of passage because of their higher stratification rate, which increases the probability that a particle will contact the screen deck during the process.
Shape-Controlled Synthesis of Copper Indium Sulfide Nanostructures: Flowers, Platelets and Spheres
Authors: Ning Jiajia , Kershaw Stephen V. , Rogach Andrey L.
Published: December 2019

Colloidal semiconductor nanostructures have been widely investigated for several applications, which rely not only on their size but also on shape control. CuInS2 (often abbreviated as CIS) nanostructures have been considered as candidates for solar energy conversion. In this work, three-dimensional (3D) colloidal CIS nanoflowers and nanospheres and two-dimensional (2D) nanoplatelets were selectively synthesized by changing the amount of a sulfur precursor (tert-dodecanethiol) serving both as a sulfur source and as a co-ligand. Monodisperse CIS nanoflowers (~15 nm) were formed via the aggregation of smaller CIS nanoparticles when the amount of tert-dodecanethiol used in reaction was low enough, which changed towards the formation of larger (70 nm) CIS nanospheres when it significantly increased. Both of these structures crystallized in a chalcopyrite CIS phase. Using an intermediate amount of tert-dodecanethiol, 2D nanoplatelets were obtained, 90 nm in length, 25 nm in width and the thickness of a few nanometers along the a-axis of the wurtzite CIS phase. Based on a series of experiments which employed mixtures of tert-dodecanethiol and 1-dodecanethiol, a ligand-controlled mechanism is proposed to explain the manifold range of the resulting shapes and crystal phases of CIS nanostructures.
A Comparison of Changes in the Fatty Acid Profile of Human Milk of Spanish Lactating Women during the First Month of Lactation Using Gas Chromatography-Mass Spectrometry. A Comparison with Infant Formulas
Authors: Sánchez-Hernández Silvia , Esteban-Muñoz Adelaida , Giménez-Martínez Rafael , Aguilar-Cordero María José , Miralles-Buraglia Beatriz , Olalla-Herrera Manuel
Published: December 2019

Breastfeeding is the ideal way to provide infants with the nutrients they need for healthy growth and development. Milk composition changes throughout lactation, and fat is one of the most variable nutrients in human milk. The aim of this study was to determine the main differences between the fatty acid (FA) profile of human milk samples (colostrum, transitional, and mature milk group) and infant formulas. Human milk samples were provided by lactating women from Granada. Moreover, different commercial infant formulas were analyzed. FAs were determined using gas chromatography coupled with mass spectrometry. According to the results, oleic acid was the predominant monounsaturated fatty acid (41.93% in human milk and 43.53% in infant formulas), while palmitic acid was the most representative saturated fatty acid (20.88% in human milk and 23.09% in infant formulas). Significant differences were found between human milk groups and infant formulas, mainly in long-chain polyunsaturated FAs (LC-PUFAs). The content of araquidonic acid (AA) and docoxahexaenoic acid (DHA) was higher in human milk (0.51% and 0.39%, respectively) than in infant formulas (0.31% and 0.22%, respectively). Linoleic acid (LA) percentage (15.31%) in infant formulas was similar to that found in human milk (14.6%). However, α-linolenic acid (ALA) values were also much higher in infant formulas than in human milk (1.64% and 0.42%, respectively).