bluuebunny/crossref_metadata_2025 huggingface dataset:
The pattern and prognostic factors for kidney function progression in children with acute kidney injury and acute kidney disease
Authors: Hui Wun Fung , Chan Vivian Pui Ying , Cheung Wing Lum , KU Shu Wing , Hon Kam Lun
Published: June 2023

Background: There is a paucity of data describing the progression of kidney function from acute kidney injury (AKI) to acute kidney disease (AKD) among children.
Methods: A prospective cohort study on pediatric AKI was conducted from 6/2020 to 6/2021 on critically ill children aged 1 month to ≤18 years old. The 90-day natural history of kidney function progression was described. Prognostic factors associated with development of AKD and various outcomes were identified.
Results: Among the 253 episodes of admission, 58.1% were male with a median (interquartile range) age of 4.9 (9.7) years The AKI incidence was 41.9% and 73.6% of children with AKI developed AKD. Parameters signifying more severe and prolonged AKI and higher degree of nephrotoxic medication exposure were significant determinants of AKI progression and AKD development. At 90 days, 31.5% of children had serum creatinine level (SCr) ≥1.5 times of baseline, 10.4% had an estimated glomerular filtration rate (eGFR) <90ml/min/1.73m2 and the mortality was 6.7%. Children with AKI followed by AKD had the highest risk of having SCr ≥1.5 times of baseline (HR 13.59 [6.07, 30.46]) and eGFR <90ml/min/1.73m2 (HR 12.56 [3.19, 49.38]). Persistent AKI was significantly associated with 90-day mortality (HR 7.06 [2.72, 18.3]).
Conclusions: Pediatric AKI survivors were at risk of developing AKD. The severity and duration of AKI and AKD were important determinants of outcomes. Children with both AKI and AKD carried the highest risk of kidney function non-recovery at 90 days. A follow-up visit is warranted for children who survived AKI.
Pulsed-aerosol assisted low-pressure plasma for thin film deposition
Authors: Carnide Guillaume , Simonnet Claire , Sadek Thibault , Parmar Divyesh , Zavvou Zaccharoula , Girardeau Adèle , Pozsgay Vincent , Verdier Thomas , Villeneuve Christina , Kahn Myrtil Louise , Stafford Luc , Clergereaux Richard
Published: June 2023

Plasma-enhanced chemical vapor deposition (PE-CVD) is intensively studied and developed to form (multi-)functional thin films. Generally produced in gases or vapors of thermodynamically stable and chemically inert precursors, aerosol assisted plasma process becomes an alternative as it enables to inject various liquid solutions independently of these characteristics. This study examines the case of pentane aerosols injected in pulsed mode in a low-pressure RF plasma. It produces diamond-like carbon thin films with material balance larger than those obtained in gaseous processes. Here, the deposition process is controlled by the pulsed injection. Indeed, the dynamics of thin film deposition result in time-dependent mechanisms at the pulse scale related to the temporary increase of the working pressure and the presence of liquid droplets in the plasma volume. Hence, thin film deposition is controlled by plasma-surface as well as plasma-droplets interactions. Consequently, aerosol-assisted plasma processes are really relevant for the deposition of (multi-)functional coatings.
Underwater versus conventional endoscopic mucosal resection for colorectal lesions: a systematic review and meta-analysis of randomized clinical trials
Authors: Souza Matheus Henrique Gonçalves , Santo Paula Arruda do Espirito , Maluf-Filho Fauze , Lenz Luciano
Published: June 2023

Purpose: Conventional endoscopic mucosal resection (CEMR) is the established method for the resection of non-pedunculated colorectal lesions (NPCRL) ≥ 10mm. In the last decade, underwater endoscopic mucosal resection (UEMR) has been introduced as a potential alternative. The aim of this systematic review with meta-analysis is to compare the recurrence and safety of UEMR and CEMR by analyzing only randomized controlled trials (RCTs).
Methods: We systematically searched PubMed, Cochrane Library and EMBASE until April 2023. Studies met the following inclusion criteria: (1) RCTs, (2) comparing UEMR with CEMR, (3) NPCRL ≥ 10 mm, and (4) reporting the outcomes of interest. Primary outcomes were recurrence and safety. Secondary outcomes were en bloc, R0, complete resection, clipping and adverse events per type.
Results: Five RCTs were included. UEMR was associated with a lower recurrence rate (OR: 0.56; 95% CI: 0.32-0.97). Thus, the RR of recurrence was 1.7 times higher in the CEMR group (95% CI, 1.04-2.77). There was no significant difference in the pooled safety analysis. UEMR showed better en bloc resection rates (OR: 1.54; 95% CI: 1.15-2.07), but subgroup analysis showed comparable rates in lesions ≥20 mm. R0 resection was higher in UEMR (OR: 1.72; 95% CI: 1.23-2.41). Other outcomes were not different between the 2 groups.
Conclusions: UEMR is as safe as CEMR, with a higher overall R0 rate and a higher en bloc resection rate for lesions < 20 mm, leading to a lower overall recurrence rate. The results of this meta-analysis support the widespread use of UEMR.
Epidemiologic Investigation of Eye Symptoms Related to COVID-19 among Outpatient Population
Authors: Eslami Fatemeh , Khazaei Salman , Ghayour Anahita Eslami- , Mohammadi Tahere
Published: June 2023

Since 2019, with the spread of the coronavirus and the emergence of new strains around the world, the effects of this virus on various organs of the body have been identified through various studies. According to these studies, the coronavirus has the ability to be transmitted through mucosal membranes, including respiratory membranes such as the nasal and conjunctival membranes. As the eyes are connected to the nasal duct through the inferior meatus, it is possible for the virus to be transmitted through this route. Wearing a mask can reduce the chance of transmission, but it can also lead to eye symptoms such as dryness. Additionally, individuals with COVID-19 experience various symptoms in their body systems. Some of these symptoms can affect the visual system and lead to blurry vision, dry eyes, foreign body sensation, tearing, and more. These symptoms can cause early eye fatigue and reduce the quality of academic and occupational performance. Since there is limited research in this area and considering the importance of this disease and its consequences, we decided to conduct an observational study on a number of COVID-19 patients referred to the clinic.
A Womb with Rheum: Providers’ Knowledge and Educational Needs in Caring for Women with Rheumatic Diseases
Authors: He Lauren , Arenas Gabriel , Karani Rachel , Faison Maya , Dade Adrianne , Edens Cuoghi
Published: June 2023

Background Patients with rheumatic diseases have unique reproductive health needs. Recent guidelines have been established by various soceities on this topic. However, the education received by women’s health providers pertaining to the recognition and management of common rheumatic diseases in child-bearing age patients is not well-defined. This study aims to assess knowledge gaps, specify aspects of care with greatest uncertainty, and assess current resources used by women’s health providers in the management of their patients with rheumatic disease. Methods An electronic survey was distributed nationally to physicians and allied health professionals who care for reproductive age women. The survey scored participants on their correct responses and confidence ratings in three sections: 1) patients presenting with a new rheumatic disease, 2) contraception in those with a known rheumatic diagnosis, and 3) preconception/antepartum rheumatology medication management. Participants were also asked about resource utilization. Survey questions and scenarios were based on American College of Obstetrics and Gynecology Committee Opinions and the American College of Rheumatology Guidelines for the Management of Reproductive Health in Rheumatic and Musculoskeletal Diseases. Data were captured using RedCap© and analyzed using descriptive statistics. Results The survey was completed by 200 participants with majority being academic obstetricians and gynecologists. Respondents scored the lowest in recognizing new rheumatic disease presentations in peri-and post-partum periods (28.7%, 95% CI: 25.9–31.6%). Contraception counseling was the area of highest accuracy (57.5%, 95% CI: 54.2–60.8%) and confidence (44.6%, 95% CI: 41.7–47.5%), although areas for contraceptive knowledge expansion exist. Approximately 70% of respondents identified online resources as their main resource used in clinical practice and would prefer more information to be provided as a website, published guidelines, or Smartphone application. Conclusions Women’s health providers lack educational opportunities to improve knowledge and confidence in managing reproductive-aged rheumatic diseases patients. Recognizing new disease presentations and antepartum medication management were identified as topics with the largest knowledge gaps. Collaborative resources are needed to fill educational needs.
HDL suppresses dendritic cell maturation and modulates CD4+ T cell subtypes against inflammatory in a mouse model of rheumatoid arthritis
Authors: Wang Xin , Lu Shulai , Li Dong , Zhang Juan , Dong Qingzhe , Jia Dongmei , Wang Yunlong , Liu Bin
Published: June 2023

Background: To investigate the mechanism of anti-inflammatory effect of High-density lipoprotein (HDL) in collagen-induced arthritis (CIA) mice.
Methods: The CIA animal model was constructed, and the mice were separated into three groups: control, CIA and CIA + HDL. In the CIA + HDL group, HDL was given on day 40, and an additional injection was administered every 3 days for a total of five doses. The levels of mouse HDL were measured by using ELISA kits, and liver, heart, kidney and colon tissue sections were stained with H＆E. Additionally, the splenic CD4+ T cell phenotypes in each group were analyzed. Immature DCs were stimulated with LPS in the presence or absence of HDL, and the expression of surface markers was investigated by FACS.
Results: HDL decreased the ratio of Th1/Th2 cells and increased the Th1/Th17 cell ratio in the CIA + HDL group compared with those of the CIA one (P<0.05). In vitro, the expression of MHC-II, CD86, and CD40 in CD11c+ BMDCs was suppressed by HDL. The level of HDL in the CIA group was significantly reduced compared with that of the control one (P<0.05), and there were no significant pathological changes in the liver, heart, kidney and colon tissues of the mice among the three groups.
Conclusion: HDL exerts anti-inflammatory effect in CIA mice by suppressing DCs maturation and modulating CD4+ T cell subtypes.
Insights on Cloud Computing: a bibliometric analysis
Authors: Nallola Sandhya Rani , Ayyasamy Vadivel
Published: June 2023

The goal of the study is to assess the volume of research on Cloud Computing (CC) and, using bibliometric analysis, to discover study patterns, growth, and evolution in the Scopus database. This study's main goal is to undertake a thorough bibliometric analysis of works that concentrate on the use, identification, network structure, and conceptual framework of CC. With the aid of an electronic search, the most pertinent articles were located. The Scopus database served as the source for the studies that will be reviewed. Between 2009 and 2023, 1,361 articles were discovered and reduced to 1009 papers. With the aid of the R programming language and the VOSviewer software, each composition has been examined in terms of co-authorship, co-citation, conceptual structure, co-word occurrence, trend topics analysis, thematic map, topic dendrogram, three field plot diagram, and visualization analysis. The rise in researchers' multi-authored, interdisciplinary, and collaborative efforts likewise showed an annual growth rate of 18.28%. Overall, this study improved knowledge of the cloud computing phenomena and helped to evaluate a variety of statistics based on publications and citations. This study contributes to our understanding of the networks of collaboration among various scholars and institutions, as well as the advantages and disadvantages of working cross-disciplinarily, globally, or with corporate or industry institutions.
A putatively new ant species from the Cataglyphis cursor group displays low levels of polyandry with standard sexual reproduction
Authors: Doums Claudie , Chifflet-Belle Pascaline , Lenormand Thomas , Boulay Raphael , Villalta Irène
Published: June 2023

How social organisation (number of queens and mating partners) and reproductive systems (use of thelytoky vs sex) evolved in ants and how they interplay is still far from clear. The Cataglyphis desert ants represent a fascinating group as it harbours variation in both levels of polyandry and the use of thelytoky, with polyandry and sexual reproduction probably being the ancestral state. In this study, we compared the colony and population genetic structure of two populations of the Cataglyphis cursor group distributed in a remote small geographic area in central Spain with those of their geographically closest species C. piliscapa and C. cursor. Not surprisingly, we found that the two populations are genetically isolated from those of C. piliscapa and C. cursor, both for the mtDNA and microsatellite markers. Interestingly, we observed a lower level of polyandry in the C. cursor from Spain even though the population genetic diversity was like C. piliscapa and C. cursor. Queens did not appear to use frequently thelytoky which supports the hypotheses that low levels of polyandry disfavours the use of thelytoky. Reversion to a lower level of polyandry has rarely been observed in ants, and we discuss multiple hypotheses that could explain this phenomenon. Whether these remote populations belong to a putatively new species requires a careful taxonomic investigation. Our study highlights the lability of the reproductive system in this group and provides an exciting system to investigate the co-evolution of polyandry and thelytoky.
Rocket Nozzle Performance Optimization Using Modified Turbulence
Authors: M Manoj , Farouk Rameez , J Bruce Ralphin Rose , R Jinu G
Published: June 2023

Vortex generators are widely used for enhancing the nozzle thrust output by creating different effects. The Ranque-Hilsh effect is observed in a swirling nozzle flow within a single tube is a spontaneous separation of total temperature. Here the colder stream near the tube centre line and the hotter air near its periphery. Hence the temperature difference due to the presence of disturbed flow can either increase (or) decrease the thrust output. This analysis is made of the velocity, temperature and pressure distribution in a turbulent vortex with radial and axial flow. The controlled flow expansion by modifying the geometry in the downstream of throat region can yield better shock expansion characteristics. The most important factor affecting the total temperature of a fluid element in a compressible vortex is the turbulent shear work done on or by the element. The parameter which is considered for this optimization of the vortex generator is exit nozzle opening area, Efficiency of Energy Separation, Profile of velocity, temperature, Length of the tube. Further the experimental investigation of output mass flow rate by geometry modification also will be studied. Computational Fluid Dynamics (CFD) based optimization procedure using the Parabolized Navier-Strokes (PNS) equation is used to design axisymmetric nozzle. The advantage of this procedure is that it accounts for viscosity during the design process. Remaining process will make an approximated Boundary Layer Correction after the inviscid design is created. The nozzle design begins with concerning control volume and the separation of Aerodynamic and Propulsive forces and moments will be demonstrated. The appropriate control volume can define the propulsive force vector that maximizes cruise efficiency. The different boundary layer thickness must be evaluated at various temperature and pressure conditions. Then the influence of boundary layer thickness in the net output will be evaluated numerically. The nozzle configuration of a truncated perfect nozzle is selected for computations. The starting process of unsteady flow characteristics and flow separation are observed carefully. The reattachment of the flow through nozzle is also visualized using the computational analysis.
No Evidence of Structural Abnormality of the Substantia Nigra in Adult Attention-Deficit/Hyperactivity Disorder: A Cross-Sectional Cohort Study
Authors: Friedrich Isabel , von Kuenheim Daniela , Wozniak David , Meyer Patrick , Mauche Nicole , Huang Jue , Classen Joseph , Strauss Maria , Rumpf Jost-Julian
Published: June 2023

Background Attention-deficit/hyperactivity disorder (ADHD) is a common neuropsychiatric disorder that has recently been associated with an increased risk of developing movement disorders such as Parkinson's disease (PD), particularly in individuals treated with psychostimulants. Abnormal expansion of the echogenic area of the substantia nigra (SN), a trait marker for PD, is also commonly found in children with ADHD, in whom this feature was attributed to maturational delay of the dopaminergic system. Here, we investigated the structural integrity of the SN in adults with ADHD and its relationship to symptomatic treatment with psychostimulants.Methods In this cross-sectional cohort study, we performed transcranial sonography of the SN in 30 adults (mean age 33.3 ± 7.6 years, 11 females) diagnosed with ADHD according to DSM-V criteria. The cumulative dose of methylphenidate was extrapolated based on the treating physicians’ documentation and patient’s reports.Results The mean echogenic SN area in our cohort amounted to 0.17 ± 0.04 cm² (mean ± standard deviation), which is well within the normal range of echogenic SN area according to consensus criteria and did not significantly differ from the mean echogenic SN area observed in two independent control groups previously collected at our site (all p ≥ 0.297). Importantly, we observed no significant treatment-associated changes of SN echogenicity with respect to the extrapolated cumulative dose of methylphenidate derivates (r=-0.261, p = 0.163).Conclusions Our results indicate that expansion of the echogenic SN area is, unlike evidence in children with ADHD, not useful as an ADHD biomarker in adults. The current results, furthermore, challenge the view that abnormal expansion of the echogenic SN in ADHD may reflect maturational delay of the dopaminergic system, at least it does not persist into adulthood. Therefore, if there is an intrinsic link between ADHD and PD, it is not reflected by structural alterations of SN echogenicity. Importantly, we found no evidence of treatment-associated changes in structural SN integrity mitigating concerns about a possible causal relationship between therapeutic psychostimulant use in ADHD and an increased risk of PD.
Dynamics of Belief: Abduction, Horn Knowledge Base And Database Updates
Authors: Delhibabu Radhakrishnan
Published: June 2023

The dynamics of belief and knowledge is one of the major components of any autonomous system that should be able to incorporate new pieces of information. In order to apply the rationality result of belief dynamics theory to various practical problems, it should be generalized in two respects: first it should allow a certain part of belief to be declared as immutable; and second, the belief state need not be de-ductively closed. Such a generalization of belief dynamics, referred to as base dynamics, is presented in this paper, along with the concept of a generalized revision algorithm for knowledge bases (Horn or Horn logic with stratified negation). We show that knowledge base dynamics has an interesting connection with kernel change via hitting set and abduction. In this paper, we show how techniques from disjunctive logic programming can be used for efficient (deductive) database updates. The key idea is to transform the given database together with the update request into a disjunctive (datalog) logic program and apply disjunctive techniques (such as minimal model reasoning) to solve the original update problem. The approach extends and integrates standard techniques for efficient query answering and integrity checking. The generation of a hitting set is carried out through a hyper tableaux calculus and magic set that is focused on the goal of minimality. The present paper provides a comparative study of view update algorithms in rational approach. For, understand the basic concepts with abduction, we provide an abductive framework for knowledge base dynamics. Finally, we demonstrate how belief base dynamics can provide an axiomatic characterization for insertion a view atom to the database. We give a quick overview of the main operators for belief change, in particular, belief updates versus database updates.
High-temperature measurements on viscosity and surface tension of the ionic liquid 1-ethyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide ([EMIM][NTf2]) up to 473 K
Authors: Zhai Ziwen , Koller Thomas M.
Published: June 2023

In the present study, the viscosity and surface tension of the commercial low-viscosity ionic liquid (IL) 1-ethyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide ([EMIM][NTf2]) were determined by a combination of surface light scattering (SLS) and the pendant-drop (PD) method between (303 and 473) K. Both methods operating at thermodynamic equilibrium were applied inside the same measurement cell at identical experimental conditions under an argon atmosphere at 0.1 MPa. For SLS measurements performed in the temperature range from (303 to 323) K, the overdamped behavior of the surface fluctuations allowed access to the viscosity with an expanded uncertainty of 2.3% by using the surface tensions determined via the PD method with an uncertainty of 2% as input quantities. Above 323 K up to 473 K, the oscillatory behavior of the probed surface fluctuations by SLS enabled a simultaneous determination of viscosity and surface tension with average expanded uncertainties of (4 and 3) %, respectively. Multiple repetition measurements by both methods have been conducted at 323 K after experiments at larger temperatures up to 473 K, and the consistency of their results could indicate a sound thermal stability of the IL sample. The mutual agreement of the surface tension results from SLS and the PD method between (353 and 473) K demonstrates that both techniques analyze the very same IL surface. For both properties, the results from this work agree well with the majority of experimental data reported in the literature typically up to 353 K. In summary, the viscosity and surface tension results presented in this study contribute to an improved data landscape for this particular IL and ILs in general at elevated temperatures.
Cancer Stem Cells Remodel the Tumor Microenvironment and Influence Immunotherapy Response in Hepatocellular Carcinoma
Authors: Zhang Xianzhou , Yang Nanmu , Zhuang Hao , Han Feng , Meng Bo
Published: June 2023

Background: Cancer stem cells are the important factors that lead to drug resistance, recurrence and metastasis of tumor. Immunotherapy has become the first-line treatment for advanced Hepatocellular Carcinoma(HCC), however, the importance of cancer stem cells in the immunotherapy of HCC has not been well elucidated.
Methods: We identified a subset of cells with stemness characteristics by analyzing single-cell sequencing data from tumor tissue samples from 10 patients with HCC. We screened these cell populations for overexpressed genes, defined as cancer stem cell-related genes. Subsequently, we comprehensively analyzed the bulk RNA sequencing data of 365 HCC patients to construct a cancer stem cell-related genes prognostic signature(CSGPS). According to the CSGPS, 365 patients with HCC were divided into high-risk and low-risk groups. Multiple independent external cohorts were used to assess the predictive value of the CSGPS. T cell receptor (TCR) richness, Cancer Testicular Antigens (CTA) scores, Microsatellite instability (MSI), expression of immune checkpoint-related genes, and Tumour Immune Dysfunction and Exclusion (TIDE) scores were used to assess the intensity of response to immunotherapy in different risk groups. Real-time quantitative polymerase chain reaction (qRT-PCR) was used to verify the mRNA expression levels of cancer stem cell-related genes in HCC tissues.
Results: CSGPS is an independent risk factor for the prognosis of HCC patients, and it is significantly superior to other clinical features in predicting the prognosis and immunotherapy response of HCC patients. Multiple independent external cohorts validated the validity and robustness of the CSGPS. Immune infiltration analysis showed that cancer stem cell-related genes can recruit immune cells with immunosuppressive functions, such as Treg, macrophages infiltration. The CSGPS was correlated with the TCR, CTA score, MSI score, expression of immune checkpoint-related genes, and TIDE score. Patients in the high-risk group identified by the CSGPS may respond more strongly to immunotherapy and be more suitable to immunotherapy. The results of qRT-PCR confirmed that 8 cancer stem cell-related genes were overexpressed in HCC tissues.
Conclusion: Cancer stem cell-related genes are overexpressed in HCC and contribute to the formation of an immunosuppressive microenvironment. Targeting cancer stem cells may become a new target for immunotherapy of HCC. Our novel prognostic signatureof cancer stem cell-related genes can effectively predict the prognosis and immunotherapy response of HCC patients. In the future, the prognostic signature will help clinicians to select the appropriate population for immunotherapy and improve the response rate of immunotherapy.
Signalling Pathway Associated to Discharge of Cnidocyst Induced by Reduced Glutathione in Hydra
Authors: GAVAZZI María Victoria , RONDEROS JORGE RAFAEL , Alzugaray María Eugenia
Published: June 2023

In the present work we study the effect of different stimuli (living preys, its homogenate, and reduced glutathione (GSH)) on the discharge of desmonemes in the freshwater cnidarian, Hydra plagiodesmica. Once confirmed their stimulatory effect, we choose GSH in order to analyse the relevance of Ca2+, the probable identity of the sensory receptor molecule, and the specific signalling pathway driving the discharge mechanism. Our results show that not only mechanical, but also chemical stimuli by itself may stimulate the discharge of desmonemes. Using calcium chelators, we verify that the discharge mechanism triggered by GSH, is dependent on calcium. By mean of drugs that inhibit proteins pertaining to canonical signalling pathways, including GPCRs, we show that GSH causes the influx of Ca2+ via L-type VGCC, and its release by mean of endoplasmic reticulum calcium channels. Moreover, our results suggest that the putative receptor for GSH is a GPCR coupled to Gq, which produces IP3 and Ca2+ as second messengers. Finally, we show that the genome of Hydra predicts the existence of the different subunits of L-type VGCC, showing a high level of conservation when compared with other groups of Metazoa.
Assisting In-Silico Drug Discovery Through Protein-Ligand Binding Affinity Prediction By Convolutional Neural Networks
Authors: Rayka Milad , Latifi Ali Mohammad , Mirzaei Morteza
Published: June 2023

Context:
In this paper, we present a new feature-generating method based on distance-weighted atomic contact to predict the binding affinity between ligands and proteins in structure-based drug design, which can distinguish between weak and strong interactions. We discuss the significance and challenges of predicting binding affinity and how recent advances in hardware and deep learning algorithms have led to the surge of applying these techniques in drug design.
Methods:
We utilize the PDBbind 2016 dataset for training our model. Our approach involves using a convolutional neural network architecture to predict the binding affinity between ligands and proteins. We investigate the impact of choosing the architecture on the performance of the model. Our best model, the Sequential Model, produces Pearson's correlation of 0.79 on the independent core set. Our results suggest that a vanilla and shallow convolutional network has more acceptable performance than a more complicated architecture specifically for this problem.
Transapical Transcatheter Aortic Valve Replacement for Severe Aortic Regurgitation in Dextrocardia: A case report
Authors: Yu Junjian , Yu Wenbo , Xiong Jianxian
Published: June 2023

Dextrocardia is a rare congenital cardiovascular malformation in which the heart is located on the right side of the thoracic cavity, with an occurrence of approximately 2/100,000. The clinical understanding of such lesions is also increasing with the continuous development of cardiovascular diagnosis and treatment technologies, and dextrocardia combined with aortic regurgitation is rare, so the treatment of such patients is usually complicated.
Understanding the Perspectives of Medical Interns on Resignation Decisions: Implications for Post-Graduate Medical workplace
Authors: Anuduang Nattapat , Choocheepwattana Panus , Savigamin Chatuthanai , Wanchaijiraboon Passakorn
Published: June 2023

Background Thailand's healthcare system has been expanded through policy changes, improved service planning, and complex care teams, yet the shortage and maldistribution of doctors remain a significant challenge, particularly in rural areas. While several interventions have been implemented to address the issue, little attention has been paid to newly graduated physicians.Objective This study aims to explore the challenges faced by this group during internship programs and how they inform decisions to resign, using data gathered from online surveys launched by the Medical Council of ThailandMethods The analysis of data from a national survey of recently graduated interns in Thailand, approved by the Chanthaburi Research Ethics Committee, was performed using basic descriptive statistics, Pearson correlation, and Spearman's rho correlation in SPSS Version 28.0.0.0,Results This study surveyed 2,431 recently graduated medical interns (84.8%) from 4 types of undergraduate medical education programs in Thailand, with 3.5% planning to resign, citing reasons such as low income, heavy workload, and poor working environment. Significant correlations were found between categorical and ordinal independent variables, such as undergraduate programs and expected salary, waiting time for scholarships, scholarship location, and interest in pursuing other careers, with the resignation plan of participants.Conclusion In conclusion, this study provides insight into the factors associated with internship resignations among newly graduated doctors in Thailand, highlighting the need for policy changes to address issues related to workload, income, and scholarship opportunities.
Applying Technology in the Workforce and Classroom during the COVID-19 Era
Authors: Jackson Phronie
Published: June 2023

Background: Nowadays, awareness, knowledge, and access to technology are necessary to succeed. There is a plethora of technologies that can be used to enhance learning and experiences in the academic setting. Introduction: UDC provided the opportunity for staff and faculty to participate in two Microsoft Innovative Educator (MIE) Initiatives, MIE Teacher Academy and MIE Leadership Academy. A serendipitous outcome of these train-the-trainer initiatives was that they not only developed knowledge and skills to utilize technology but also developed soft skills and a community where staff and faculty-built camaraderie and a community to support each other in learning technology. Method: A MIE Professional Learning Community (MIE PLC) was established. During the sessions administrators who participated in the Microsoft Innovative Educator Academy was able to network with faculty who participated in the Microsoft Innovative Educator Leadership Academy. The PLC was a time for participants to commune about best practices and practical uses of the application learned during the training. Data: Three one-hour MIE PLC meetings were held. Several faculty and staff from a variety of colleges and departments participated and some volunteered to demonstrate specifically how they utilized the various applications. Results: The MIE initiative created awareness of available, accessible, and impactful technology to our PLC. Discussion: This initiative can be duplicated in future academic years and with multiple academic institutions. Conclusion: These types of professional development initiatives are beneficial to all stakeholders of the university.
COVID-19 in Context: A Pandemic in Its Historical Context
Authors: Anglim Christopher Thomas
Published: June 2023

Mindful of history’s value in providing context for contemporary issues, this essay compares selected issues surrounding the effectiveness of government messaging during COVID-19 with previous pandemics and epidemics on selected public policy choices, specifically addressing the role of disinformation, misinformation, and information suppression in contending with disease outbreaks. During the Spanish Flu of 1918, governments worldwide ignored the crisis and suppressed information on the pandemic, because they were concerned that it would interfere with the ongoing war effort. Similar to the impacts of COVID-19, leaders dismissed science in favor of ideology which occurred in the cold war era for several reasons, and with profound impacts. In the case of the Cold War, anti-Communist hysteria led Dr. Albert Sabin to test his anti-polio vaccine in the Soviet Union as opposed to the United States. In exploring various historical parallels to COVID-19, this essay also explores racism, ethnocentrism, and various forms of othering that have historically characterized the response to pandemics, often assigning blame to various “outside” groups. The essay concludes by arguing for science-based solutions to pandemic emergencies (as opposed to ideological-oriented objectives) and argues for a fair, prudent, and judicious balancing of cherished individual rights and individual autonomy, a collective science-based response to public health emergencies, and with the intent to protect the public health of all Americans in a fair, inclusive and equitable manner.
Magnetic properties of a multicomponent intermetallic compound Tb$_{0.25}$Dy$_{0.25}$Ho$_{0.25}$Er$_{0.25}$Al$_2$
Authors: Jesla P. K. , Arout Chelvane Jeyaramane , Nirmala R
Published: June 2023

Polycrystalline multicomponent Laves phase rare earth intermetallic compound Tb_{0.25}0.25 Dy_{0.25}0.25Ho_{0.25}0.25Er_{0.25}0.25Al_{2}2 has been synthesized by arc-melting and characterized by powder X-ray diffraction, magnetization and heat capacity measurements. The sample has MgCu_22-type cubic structure (space group Fd-3m) at 300 K. The compound Tb_{0.25}0.25Dy_{0.25}0.25Ho_{0.25}0.25Er_{0.25}0.25 Al_{2}2 orders ferromagnetically at 50 K (T_CC). This value is almost equal to the average of the ferromagnetic ordering temperatures of the individual RAl_22 (R = Tb, Dy, Ho and Er) compounds. Field dependence of magnetization below T_CC indicates soft-ferromagnetic nature. From the magnetization vs field data obtained near T_CC and the temperature dependence of heat capacity, low field magnetocaloric effect has been estimated.
Local investigation of the crystal electric field ground-state in CeCu(Sb,Bi)$_2$ heavy fermions
Authors: Zau Davi , Freitas G. S. , Pagliuso Pascoal G. , Urbano Ricardo R.
Published: June 2023

In this work, we performed systematic Nuclear Magnetic Resonance (NMR) and magnetic susceptibility experiments in CeCuSb_22 single-crystals. The main findings were compared to previous report for CeCuBi_22. The NMR spectra and transferred hyperfine coupling for the ^{63}63Cu nuclei were obtained aiming to observe their correlation with the crystal electric field (CEF) effects on the Ce^{3+}3+ (J=5/2J=5/2) multiplet. Besides, in an attempt to elucidate the magnetic structure through NMR measurements at different magnetic fields orientations, we observed a magnetic transition at T\approx 8\,T≈8K higher than the Néel temperature T_NTN measured by magnetic susceptibility indicating the development of short-range magnetic ordering above T_NN. In addition, the wipe out of the main NMR resonance line and a persistent spin-echo signal throughout the whole frequency-swept range suggest the possibility of an incommensurate magnetic structure in CeCuSb_22. Furthermore, the small transferred hyperfine coupling constant found for CeCuSb_22 indicates a scenario with more localized Ce^{3+}3+ 4f electrons than for CeMIn_55 (M == Co,Rh,Ir) heavy fermions family. Additionally, subtle changes in the hybridization between the ^{63}63Cu with the 4f^11 Ce^{3+}3+ electrons in distinct magnetic field orientations allowed us to provide detailed information and map out the 4f CEF orbital ground-state of CeCu(Sb,Bi)_22 via NMR measurements.
IMPACT OF GANDHIAN VALUES ON NATIONAL SERVICE SCHEME IN INDIA
Authors:   Assistant Professor of Sociology, Serampore Girls College., Ghosh Aritra
Published: June 2023

The idea of social service in India became much popular in the time of Mahatma Gandhi who always urged his followers for service to the common people. He calls upon the Indian youth to indulge their energy and spirit to the work of nation building. After Independence, the Government of India introduced National Service Scheme (NSS), a students social service scheme for youth and social development. The National Service Scheme was started to establish a meaningful linkage between the Campus and the Community. Mahatma Gandhi, the Father of the Nation, believed in Manava Seva ya Madhava Seva Service to man is service to God, he had recognised that the country could not progress in a desired direction until the student youth, who are committed, sincere and dedicated to the nation were motivated to work for the upliftment of the villages/slums/ community. In this paper author would like to establish the relationship between Gandhian values or Gandhian philosophy with the National Service Scheme.
EFFECTIVENESS OF EPSOM SALT HOT WATER APPLICATION ON KNEE JOINT PAIN AMONG ELDERLY PEOPLE AT SELECTED OLD AGE HOME
Authors:   Department of Community Health Nursing, State College of Nursing Dehradun, Uttarakhand., Roy Sucheta , Kumar Sharma Ram ,   Associate Professor, Departmentof Mental Health Nursing, State College of Nursing, Dehradun, Uttarakhand, India.
Published: June 2023

Background: Osteoarthritis is a progressive musculoskeletal joint disorder of basically Knee, Hip, and Shoulder among which Knee OA is highly prevalent. Bilateral Knee OA is dominant over Unilateral Knee OA. Obesity, age, gender, educational background, and occupation were included in the risk factors of OA. Prevalence of Knee OA is reported more in highly obese geriatric female patients who have low education and did hard work. Objective: To evaluate the effectiveness of Epsom salt hot water application on knee joint pain among elderly people at selected old age homes. Material and methods: The study used a quasi-experimental approach with two groups pretest-posttest non-randomized control group design. purposive sampling technique was used to collect data from 60 old age people with age groups above 60 from selected old age homes in Dehradun. Result: The Epsom salt hot water application has shown a Highly significant difference ( t=30.077 at p-value .OO1) between the pretest and posttest with a mean +SD of 6.233Â± 1.135 in the experimental group was significant at p<0.05 level.Independent t test was used for significant comparison between the experiment and control in the post-test with meanÂ±SD 3.40Â±1.44, the obtained Independent t value 2.346 was significant at p-value= 0.022. Post-test had a higher mean score in the experimental group than in the control group. Conclusion: This study concluded that Epsom salt hot water application is effective in reducing knee joint pain.
Investigating the Role of Foreign Direct Investment on Youth Unemployment Rate in Indonesia
Authors: Tanaya Olivia , Suyanto Suyanto
Published: June 2023

Youth unemployment is a contemporary socioeconomic problem in many countries. Although it is a negative phenomenon, this number can be translated into different perspectives as it offers plenty of available job force not only in terms of age and easily adaptable workers but also opportunities for low-wage workers. Unfortunately, despite having a high Foreign Direct Investment (FDI) and economic growth rate, Indonesia still suffers from the youth unemployment problem. The research observed a relationship between youth unemployment and FDI in the case of Indonesia from 1991 until 2019. Because of a different situation faced by female and male workers, the research also extended the impact of FDI into gender-specific effects. Data were from World Development Indicator (WDI) in 1991-2019. The short- and long-run situations were analyzed using the Auto-Regressive-Distribution-Lag (ARDL) technique. Based on the findings, it is found that in the short run, FDI can increase youth unemployment in Indonesia. This situation can be due to the reallocation industry, which requires workers’ adjustment. However, in the long run, FDI significantly reduces youth unemployment. Therefore, it concludes that FDI in Indonesia can provide employment opportunities for young people. Next, FDI is found to have a negative and significant effect on female youth unemployment. Meanwhile, there is no significant effect found in male youth unemployment.
Symbolic Meaning in the Commemoration Ceremony of Sultan Hamengku Buwono X Coronation in COVID-19 Pandemic
Authors: Nur'aini Fitria , Sumarwati Sumarwati , Sulaksono Djoko
Published: June 2023

The research aimed to (1) describe the procession and ubarampe offerings in the commemoration ceremony of Sultan Hamengku Buwono X’s coronation during the COVID-19 pandemic, and (2) analyze the symbolic meaning of it. The research applied a qualitative research that used an ethnographic approach. Data collection techniques used were passive participant observation techniques and in-depth interviews with abdi dalem (courtier) of Yogyakarta palace and cultural experts. So, the selection of research subjects used the snowball sampling technique. The data obtained were validated by the source triangulation method, and it was then analyzed using the Spradley model research method, which included domain analysis, taxonomic analysis, compensatory analysis, and analysis of cultural themes. The research result show that (1) the procession of the commemoration of the coronation of Sultan Hamengku Buwono X consists of a series of ceremonies, including ngebluk, ngapem, sugengan, and labuhan. The ceremony is organized well during the COVID-19 pandemic by wearing a mask when carrying out daily activities, washing hands often, especially after outdoor activities, social distancing, avoiding crowds, and restricting mobilization and interaction, (2) the symbolic meaning of the procession and ubarampe offerings Sultan Hamengku Buwono X is asking God for the safety and welfare of the Sultan and his family in particular and Yogyakarta people in general.
Impact of Japanese Popular Culture to Indonesian younger Generation:
Authors: Bangsa Bunga Putra , Sihombing Lambok Hermanto
Published: June 2023

The research probed into the influence of Japanese popular cultures on the Indonesian-younger generation in Cikarang, West Java, Indonesia. Japanese popular culture had been famed among the younger generation in Indonesia through the increasing popularity of anime. Indonesia, with 1.400 ethnic groups, had a variety of cultural diversity, but the younger generation seemed to be fonder of this foreign culture which in this case was Japanese popular culture. Through the expansion of this Japanese popular culture, Japanese culture could slip into it and could invade their local culture. This cultural expansion could have an impact on how the younger generation would preserve their local culture. Globalization also played a massive part in this cultural expansion; through the internet, it was easier to find something with foreign culture in it. The research used phenomenology research about the Japanese popular culture club of President University Nippon Community (PUNICO) in Cikarang. The research applied a qualitative approach with phenomenology methods. Data collection was done by asking the respondents questions regarding the matter. The respondents were ten members of PUNICO. The research result indicates that Japanese popular culture has been in the respondent's life long enough to change their habits and lifestyle. However, the respondents still care and have the volition to preserve their local cultures.
Evaluation of Extraction Parameters for the Analysis of Lipid Classes in Plants
Authors: Matos Taynara , Marques Mariana , Chaves Cleber , Zandonadi Flávia , Palma-Silva Clarisse , Sussulini Alessandra
Published: June 2023

The aim of this study was to preliminary evaluate the lipid profile alterations on Pitcairnia flammea leaves based on variations in solvent proportion and ultrasonic ice bath extraction time, followed by a lipid class-enriched analysis employing chemometric techniques. Ultra-high performance liquid chromatography coupled to electrospray ionization mass spectrometry (UHPLC-ESI-MS) was used to acquire raw data and MS-DIAL and MetaboAnalyst platforms were used to perform data preprocessing and statistical analysis. The statistical analysis of UHPLC-ESI-MS data in both ionization modes enabled the visualization of a trend distribution based on extraction time. Furthermore, we were able to establish that the solvent proportion had a greater impact on group separation in data samples extracted for 30 min versus 10 and 20 min. Moreover, diacylglycerol or/and lysophosphatidylcholine are lipid subclasses that can be favored depending on the extraction time in the mass spectrometry analyses using positive electrospray ionization mode.
The role of project components for the acceptance of an inner city river restoration project in Bad Bergzabern, Germany
Authors: Weiß Sören Bo , Schilling Janpeter , Frör Oliver
Published: June 2023

The poor conditions of rivers worldwide make restoration an issue of great importance and urgency. The acceptance of restoration by society is crucial, however, the factors determining such acceptance are still poorly understood. In particular, the understanding of the complex interplay between the acceptance or rejection of specific project components and the acceptance of the overall project require further exploration. To address this research gap, we analyze a restoration project in Bad Bergzabern, Germany to (1) investigate the acceptance of the overall project and its components, and (2) explore why people accept or reject specific components. Three hundred and twenty-one in-person interviews were conducted and the factors of acceptance were analyzed using logistic regression. Our findings show that while acceptance of the overall project is generally high, many respondents reject one or more project components. Complementary social project components, like a playground, find less support than purely ecological components. Overall, our research shows that differences in the acceptance of components depend on individual concerns, the quality of communication, attachment to the site, and age. Our results contribute to a better understanding of preferences for river restoration projects and help water managers design restoration projects that are highly accepted by society.