bluuebunny/crossref_metadata_2025 huggingface dataset:
Matrix-assisted laser desorption ionization-time-of-flight mass spectrometry in veterinary medicine: Recent advances (2019–present)
Authors: Thompson Jonathan E.
Published: November 2022

Matrix-assisted laser desorption ionization-time-of-flight (MALDI-TOF) mass spectrometry (MS) has become a valuable laboratory tool for rapid diagnostics, research, and exploration in veterinary medicine. While instrument acquisition costs are high for the technology, cost per sample is very low, the method requires minimal sample preparation, and analysis is easily conducted by end-users requiring minimal training. Matrix-assisted laser desorption ionization-time-of-flight MS has found widespread application for the rapid identification of microorganisms, diagnosis of dermatophytes and parasites, protein/lipid profiling, molecular diagnostics, and the technique demonstrates significant promise for 2D chemical mapping of tissue sections collected postmortem. In this review, an overview of the MALDI-TOF technique will be reported and manuscripts outlining current uses of the technology for veterinary science since 2019 will be summarized. The article concludes by discussing gaps in knowledge and areas of future growth.
Preparation and evaluation of a lateral flow immunochromatographic nanogold diagnostic kit for brucellosis in sheep
Authors: Aboelqassem Zainab Mohammed , Ibrahim Hazem Mohammed , Sayed Rafik Hamed , Sobhy Hassan Mohamed , Hekal Sahar Hussein Abdalla
Published: November 2022

Background and Aim: Brucellosis is a zoonotic disease with a worldwide distribution. It has a serious impact on the health of humans and animals, along with a negative impact on the economy. This study aimed to prepare and evaluate the diagnostic performance of a lateral flow immunochromatographic test (LFIT) nanogold diagnostic kit for detecting brucellosis in sheep.

Materials and Methods: A rapidly developed LFIT, in which lipopolysaccharide conjugates with nanogold molecules, was placed on the conjugate pad. One hundred ovine serum samples were tested to detect Brucella antibodies (Ab) using the prepared lateral flow immunochromatography assay (LFA) kit and Rose Bengal test. The evaluation of specificity, sensitivity, and accuracy for LFIT and Rose Bengal plate test was conducted using the P04310-10 IDEXX brucellosis ovine/ caprine Ab enzyme-linked immunosorbent assay (ELISA) test (gold standard).

Results: The lower amount of Brucella Ab in the ovine serum samples was detected and was 1.58 S/P ratio ELISA titer/100 μL using LFIT and with Rose Bengal to detect 1.86 S/P ratio ELISA. The results showed that the developed LFIT had high specificity with no cross-reactivity with other tested bacteria. The calculated sensitivity, specificity, and accuracy of LFIT and Rose Bengal test using the P04310-10 IDEXX brucellosis ovine/caprine Ab ELISA test (gold standard) were 74% and 89%, 81% and 59%, and 76.9% and 66%, respectively.

Conclusion: The present results showed interesting results implying that the LFIA strip test could be used as a substantial diagnostic tool for field screening ovine Brucella as an essential step in the control of brucellosis. However, further studies for the validation of the present findings are necessary.
The Mediating Role Of Organizational Justice On Organizational Commitment And Turnover Intention Of Employees
Authors: Budomo Xerxes
Published: November 2022

Perceived organizational justice and organizational commitment are both considered important factors to an organization to avoid high turnover among its workforce. There has been a rich literature for each of these variables. The main objective of this study is to determine the mediating role of organizational justice on organizational commitment and turnover intention among employees. The result is envisioned to provide meaningful insights for academicians and business industries especially in the HR side as basis for strategy and policy formulation. This study was conducted using the five (5) Business Process Outsourcing (BPO) companies in Tarlac and Clark areas as the locale and 360 millennial employee respondents as the unit of analysis. Along with the study, the researcher adopted instruments to gather the necessary data. Descriptive analysis was used to determine the organizational justice, organizational commitment, and turnover intention of the respondents. While, mediation analysis was used to determine the effect of organizational justice on organizational commitment and turnover intention. Based on the results, organizational commitment and organizational justice got an overall slightly agree description while turnover intention items got an overall slightly iv disagree description. The relationship of organizational commitment and turnover intention is not significant, however the relationship between organizational justice and turnover intention is significant. Overall, the effect of organizational commitment on turnover intention was fully mediated via organizational justice. Furthermore, the regression coefficient between organizational commitment and organizational justice and the regression coefficient between organizational justice and turnover intentions was significant.
The Role of Malaysian Higher Education in IR 4.0
Authors:   Universiti Malaya, Cheok Cheong Kee , Ran Li ,   Universiti Malaya
Published: November 2022

Defining the 4th Industrial Revolution (IR4.0) as the “digital revolution” which combines human and technological capabilities in industry, this paper poses two questions. First, what is the country’s level of attainment of IR4.0 Second, in preparing the population to take advantage of IR4.0, what is the role of higher education and what challenges does this sector face in pursuit of this goal? In Malaysia, the government has rosy projections of IR4.0 adoption, but on-the-ground surveys do not concur. The answer to the second question lies in the preparedness of this sector in meeting the challenges of migration to IR4.0. And in terms of IR4.0 training, competency deficiencies existed among many higher education instructors. With industry still lagging behind IR4.0 adoption, teaching IR4.0 skills is still necessary.
Вопросы существования и единственности решения одного класса нелинейных интегральных уравнений на всей прямой
Authors: Хачатрян Хачатур Агавардович , Khachatryan Khachatur Aghavardovich , Петросян Айкануш Самвеловна , Petrosyan Haykanush Samvelovna
Published: November 2022

Исследуется класс нелинейных интегральных уравнений со стохастическим и симметричным ядром на всей прямой. При определенных частных представлениях ядра и нелинейности уравнения вышеуказанного характера возникают во многих разделах математического естествознания. В частности, такие уравнения встречаются в теории $p$-адических струн, в кинетической теории газов, в математической биологии и в теории переноса излучения. Доказываются конструктивные теоремы существования неотрицательных нетривиальных и ограниченных решений при различных ограничениях на функцию, описывающую нелинейность уравнений. При дополнительных ограничениях на ядро и на нелинейность доказывается также теорема единственности в определенном классе ограниченных и неотрицательных функций, имеющих конечный предел в $\pm \infty $. В конце приводятся конкретные прикладные примеры ядра и нелинейности, удовлетворяющие всем ограничениям доказанных утверждений.
Analisis Difusi Inovasi pada Inovasi Produk Batik di Kelurahan Jenggot Dalam Mendukung Upaya Pengembangan Ekonomi Lokal Kota Pekalongan
Authors: Isra Aulia Rachmi , Muktiali Mohammad
Published: November 2022

The development of innovation in a particular area cannot be separated from the diffusion of innovation. This diffusion of innovation occurs because of the process of social interaction by related actors in the region. This is explained by Rogers (2003), that the diffusion of innovation is a process when innovation is communicated or mentioned through certain channels for a certain period of time to members of a social system, which then becomes part of the social system. With the diffusion of innovation, an area will experience changes in certain conditions due to the impact of emerging innovations, which will play a role in developing the character of the region. As happened in Jenggot village, the emergence or entry of new patterns influenced changes in the market in terms and the direction of development of the existing batik patterns in the village. Batik patterns that were originally patterned and impressed monotonously with plant and animal-based patterns are becoming more contemporary and fashionable. The diffusion of innovation helps business owners either directly or indirectly in promoting their batik products. Thus increasing the value of the batik product itself.
Tipologi Home-based Enterprises di Sentra Industri Makanan Olahan Bandeng Kota Semarang Berdasarkan Tiga Modal Sustainable Livelihood
Authors: Khusna Izzah , Tyas Wido Prananing
Published: November 2022

The Center for Milkfish Processed Food Industry are scattered in several areas, three of which are located in Semarang Barat, Gayamsari, and Semarang Utara districts which has the largest milkfish production and investment value in Semarang City. Inside, there are Home-based Enterprises (HBE) for milkfish processing with various characteristics. There are 3 main points indicated that the existence of HBE for milkfish processing is a potential that can be developed, including SMEs, culinary tourism, and thematic villages. To develop that, it is necessary to identify the character of each HBE unit in the three districts. This study aims to identify the typology of HBE at the Center for Milkfish Processed Food Industry in Semarang City to identify the characters and prerequisites for the development of HBE types by using 3 sustainable livelihood asets as the determinant of research variables. The results showed that there were 3 types of HBE which formed by 51 units. Small HBEs is a group that tends to have lower capabilities in natural, human, and financial capital than other types. Middle profile HBEs is a group identified with abilities in a higher educational background and broader marketing. High profile HBEs is a group with higher capabilities in natural, human and financial capital than other types, so that it is possible to have a more stable and sustainable livelihood.
DAYA DUKUNG LAHAN PERMUKIMAN KECAMATAN GUNUNGPATI
Authors: Hirmawan Rahmat , Pigawati Bitta
Published: November 2022

The existence of the Semarang State University College in Gunungpati District can attract residents to come and have activities in the educational area. This condition causes an increase in population and expansion of residential areas in Gunungpati District. It is feared that the phenomenon of the expansion of uncontrolled residential areas could lead to environmental degradation. This study aims to assess the carrying capacity of residential land in Gunungpati District based on an analysis of land suitability and land capability referring to the Minister of Public Works Regulation No. 20 of 2007. Using a spatial approach method with weighting and scoring analysis techniques. The results showed that the carrying capacity of residential land in Gunungpati District varied from low to high carrying capacity. Most of the Gunungpati area has a low land carrying capacity, but it can still be developed for settlements if improvements are made to infrastructure and water availability, while the Sekaran Village area is the best location for residential areas because it has high land carrying capacity based on various aspects of consideration.
Design, synthesis, and cytotoxicity evaluation of novel thiophene, pyrimidine, pyridazine, and pyridine: Griseofulvin heterocyclic extension derivatives
Authors: El-Sharkawy Karam A. , AlBratty Mohammed , AlHazmi Hassan A. , Najmi Asim
Published: November 2022

Griseofulvin, an antifungal drug, has also shown good antiproliferative activity previously. This study was aimed to synthesize heterocyclic extension derivatives of griseofulvin and test them against cancer cell lines. Griseofulvin was hydrolyzed to afford griseofulvic acid (1) followed by hybridization with important heterocyclic moieties. Initially, the active methylene group of the 1,3-cyclohexanedione moiety in 1 was utilized to synthesize fused thiophene derivatives (4a and b) by reacting with malononitrile or ethyl cyanoacetate together with elemental sulfur. Compounds 4a and b were further converted to fused pyrimidine derivatives (5a–d) using ethyl isothiocyanate or phenyl isothiocyanate. Compound 1 was also reacted with aryldiazonium chlorides to synthesize compounds 6a and b, which were used to prepare fused thiophene derivatives (7a–d). The resulting thiophenes (7a–d) underwent cyclization to produce fused pyridazine derivatives (8a–d). In addition, fused pyridine derivatives (10a and b) were also prepared by the reaction of 4a and b with ethyl cyanoacetate using two different catalytic bases. The first was triethylamine to form 10a and b in two steps via 9a and b, and the second was sodium ethoxide to afford 10a and b in one step. Finally, 9a and b underwent cyclization in the presence of acetylacetone to yield compounds 11a and b. The structures of synthesized compounds were confirmed using IR, 1H NMR, 13C NMR, and mass spectrometry techniques. The synthesized compounds were subjected to cytotoxic screening against three tumor cell lines and presented good to excellent cytotoxic profiles. Compounds 4a and 11a showed significant inhibitory activity against the three cell lines compared to the standard drug doxorubicin.
The roles of HDAC with IMPDH and mTOR with JAK as future targets in the treatment of rheumatoid arthritis with combination therapy
Authors: Mane Reshma Rajendra , Kale Pravin Popatrao
Published: November 2022

Various studies have shown that cytokines are important regulators in rheumatoid arthritis (RA). In synovial inflammation alteration of the enzyme HDAC, IMPDH enzyme, mTOR pathway, and JAK pathway increase cytokine level. These increased cytokine levels are responsible for the inflammation in RA. Inflammation is a physiological and normal reaction of the immune system against dangerous stimuli such as injury and infection. The cytokine-based approach improves the treatment of RA. To reach this goal, various researchers and scientists are working more aggressively by using a combination approach. The present review of combination therapy provides essential evidence about the possible synergistic effect of combinatorial agents. We have focused on the effects of HDAC inhibitor with IMPDH inhibitor and mTOR inhibitor with JAK inhibitor in combination for the treatment of RA. Combining various targeted strategies can be helpful for the treatment of RA.
Immunohistochemical distribution of Bcl-2 and p53 apoptotic markers in acetamiprid-induced nephrotoxicity
Authors: Nur Gokhan , Caylak Emrah , Kilicle Pinar Aksu , Sandayuk Safak , Celebi Ozlem Onen
Published: November 2022

Pesticides, which adversely affect the critical metabolic processes of organisms, disrupt the physiological balance by specifically targeting enzymes and may lead to such consequences that may lead to death. It provides benefits in agricultural activities. The p53 protein antagonizes bcl-2, an anti-apoptotic protein character, and induces apoptosis by causing mitochondrial membrane permeability. This study aims to show the effect of acetamiprid, which is an insecticide from the neonicotinoid class, on bcl-2 and p53 immunoreactivity, which has an important place in the apoptotic mechanism in kidney tissue. A total of four groups including control and three experimental groups (the acetamiprid was administered 5, 10, and 15 mg kg−1) were formed in the study. After acetamiprid was administered via gavage for 14 days, the kidney tissues taken from the mice, which were sacrificed by cervical dislocation, were fixed in 10% formaldehyde solution for histological and immunohistochemical analyses, and as a result of routine tissue follow-up, the sections were blocked in paraffin and stained with haematoxylin–eosin and immunostaining. The histopathological examinations revealed that while the kidney tissue had a normal structure in the control group, degeneration in the distal and proximal tubules, glomerular degeneration, increase in the capsular area, glomerular atrophy, and haemorrhage were determined in the acetamiprid groups at increasing severity and frequency depending on the dose of the applied substance. In the kidney tissue, Bcl-2 and p53 immunoreactivity was observed in glomerular cells, sinusoidal epithelium, and proximal and distal tubule cells. The acetamiprid caused pathological changes in the kidneys in the dose range used. This effect also affects the expression of bcl-2 and p53 genes, which are biomarkers in the apoptotic mechanism. As acetamiprid accumulates in tissues, it increases the expression of p53 from cell death receptors, while suppressing the anti-apoptotic bcl-2 expression.
Ovarian aging: mechanisms and intervention strategies
Authors: Zhu Zhengmao , Xu Wanxue , Liu Lin
Published: November 2022

Ovarian reserve is essential for fertility and influences healthy aging in women. Advanced maternal age correlates with the progressive loss of both the quantity and quality of oocytes. The molecular mechanisms and various contributing factors underlying ovarian aging have been uncovered. In this review, we highlight some of critical factors that impact oocyte quantity and quality during aging. Germ cell and follicle reserve at birth determines reproductive lifespan and timing the menopause in female mammals. Accelerated diminishing ovarian reserve leads to premature ovarian aging or insufficiency. Poor oocyte quality with increasing age could result from chromosomal cohesion deterioration and misaligned chromosomes, telomere shortening, DNA damage and associated genetic mutations, oxidative stress, mitochondrial dysfunction and epigenetic alteration. We also discuss the intervention strategies to delay ovarian aging. Both the efficacy of senotherapies by antioxidants against reproductive aging and mitochondrial therapy are discussed. Functional oocytes and ovarioids could be rejuvenated from pluripotent stem cells or somatic cells. We propose directions for future interventions. As couples increasingly begin delaying parenthood in life worldwide, understanding the molecular mechanisms during female reproductive aging and potential intervention strategies could benefit women in making earlier choices about their reproductive health.
Es ist Zeit, sich aus wirtschaftlichen Abhängigkeiten zu lösen
Authors: Grimm Veronika , von Rüden Christina
Published: November 2022

Der Erfolg der deutschen Wirtschaft beruht wie in kaum einer anderen großen Volkswirtschaft auf der Liberalisierung des Handels und der Integration in internationale Wertschöpfungsketten. Der Konflikt mit Russland verdeutlicht nun, wie sehr die Abhängigkeit der deutschen Wirtschaft die Handlungsspielräume Deutschlands und der Europäischen Union einschränkt. Neben der Energieversorgung rücken insbesondere Abhängigkeiten im Zusammenhang mit kritischen Rohstoffen in den Fokus, ohne die die grüne Transformation in Europa nicht gelingen kann. Bestehende Abhängigkeiten sollten daher schnell identifiziert und reduziert werden. Der Beitrag ist vor diesem Hintergrund der Frage gewidmet, wie dies im Kontext wachsender geopolitischer Spannungen gelingen kann. Veronika Grimm und Christina von Rüden zeigen, wie Europa durch eine Diversifizierung von Lieferbeziehungen und einen Ausbau der eigenen Kapazitäten zur Energieerzeugung und Rohstoffproduktion seine strategische Autonomie stärken kann, ohne seine Offenheit und die damit verbundenen politischen und wirtschaftlichen Vorteile unnötig einzuschränken.
Views on the Complexity of Legal Translation
Authors: Cosmulescu Andreea Maria
Published: November 2022

Legal translation has acquired ever increasing importance within translation studies. The paper focuses on the complexity of legal translations on account of a series of characteristics such as: lack of equivalent terminology, cultural differences, legal style conventions, etc. It turns out that legal translation is a special type that involves mediating between different languages and different cultures and legal systems.
Boda bodas: The new form of adventure tourist transportation in Uganda
Authors: Ochieng Amos , Kule Cosmas
Published: November 2022

Tourist transportation at local destinations has transformed, with the use of motorcycles (Boda-bodas) becoming popular, especially for adventurous tourists. In Uganda, motorcycle taxis, also known as Boda-bodas are now popular as both a mode of tourist mobility and a tourist product. This paper makes one of the first attempts to integrate the Ugandan Boda-boda tourist transport into the global tourism academic debate. Results show a surge in the number of private operators who are providing affordable and flexible transport services to both locals and tourists. As such, more Boda-boda riders are joining government licensed associations/orgamisations for authentication. Despite its growing popularity, Boda-boda transport is still associated with challenges of road accidents and loss of clients’ property mainly due to poor enforcement and observance of road traffic and safety regulations coupled with the current poor state of the roads. Going forward, there is an urgent need to institutionalize Boda-boda tourist transport to ensure safety and security of tourists and their property as well as other road users.
Warriors’ blazing heads and eyes, Cú Chulainn and other fiery cyclopes, ‘bright’ Balar, and the etymology of Old Irish cáech ‘one-eyed’
Authors: McCone Kim
Published: November 2022

Feurige Ausstrahlungen aus dem Kopf bzw. den Augen eines von Wut erhitzten Kriegers sind in den Literaturen mehrerer indogermanischer Völker belegt. Die Möglichkeit, derartige und andere feurige Aspekte mit dem anderswo (z. B. McCone 1996 und 2021) untersuchten kriegerischen Merkmal der Einäugigkeit zu verbinden, begründet einen offensichtlichen bzw. vermuteten etymologischen Zusammenhang zwischen Licht oder dgl. und sowohl den Namen einiger mythischer Zyklopen (z. B. Arges, Steropes und Balar) als auch gewissen Bezeichnungen der Einäugigkeit im allgemeinen wie lat. luscus und griech. κύκλωψ. Das Schicksal von Balar in der irischen Erzählung Cath Maige Tuired wird in Anlehnung an Ginevra (2020) auf die Rekonstruktion eines uridg. Mythos bezogen, der die Verblendung (und womöglich auch Tötung) eines ‘glänzenden’ einäugigen Ungeheuers durch eine von einem hinterhältigen Gott bzw. Held geworfene spießartige Waffe darstellt. Zum Schluß werden air. cáech, lat. caecus usw. auf eine uridg. Wurzel *keh₂i ̯‘brennen, leuchten’ zurückgeführt.
How much syntactic complexity could sixteenth-century Welsh cope with? The case of Maurice Kyffin’s Deffynniad Ffydd Eglwys Loegr (1595)
Authors: Poppe Erich
Published: November 2022

Der Aufsatz untersucht syntaktische Strukturen in Maurice Kyffins Deffynniad Ffydd Eglwys Loegr ‚Verteidigung des Glaubens der Kirche Englands‘ (1595) hinsichtlich der Varianz ihrer Komplexität. Er versteht sich damit als ein Beitrag zur Entwicklung von Methoden und Kriterien für eine syntaktische und stilistische Analyse frühneukymrischer Prosa. Deffynniad Ffydd ist eine Übersetzung von John Jewels lateinischer Apologia Ecclesiae Anglicanae, die Kyffin unter Berücksichtigung von Lady Anne Cooke Bacons englischer Übersetzung anfertigte, was vor zusätzliche methodische Probleme stellt. Hier wird jedoch kein Übersetzungsvergleich im Hinblick auf die Umsetzung des Ausgangstexts unternommen, sondern die syntaktische Form des kymrischen Texts wird als eigenständige Leistung betrachtet und analysiert. In einer ersten Mikrostudie wird dabei ein qualitativer Ansatz mit syntaktischen Detailuntersuchungen ausgewählter Sätze verfolgt. Dieser wird in einer zweiten Mikrostudie durch einen quantitativen Ansatz ergänzt; dabei werden Sätze aus gleichmäßig über den Text verteilten Passagen hinsichtlich ihrer Länge und der Anzahl ihrer subordinierten Phrasen ausgewertet. Kyffins teilweise hierarchisch sehr gegliederte Syntax und sehr langen Sätze zeigen, dass Übersetzungen ein mögliches Sprungbrett für die Ausbildung syntaktisch komplexer Sätze im Frühneukymrischen waren.
New Foam Control Additives for Agrochemicals
Authors: Garris John
Published: November 2022

Crop science specialists and manufacturers are constantly innovating to produce better and safer agrochemicals to meet the agricultural challenge of feeding the world's growing population. Foam control additives are incorporated into agricultural pesticides and nutrient formulations that use surfactants and other formulants to help deliver pesticide ingredients and nutrients to domesticated plants. These pesticide and nutrient formulas are, in general, very concentrated to minimize shipping costs, and many are dissolved or dispersed in water either during production or when diluted before field application. Foam control additives are added to these formulations to prevent foam during the mixing and packaging process at production, as well as when materials are diluted and applied on growing plants in the field. A foam control additive is a high-performance, low-use-level constituent of many agricultural pesticide and nutrient formulations. Foam control additives in many cases are an afterthought to many formulators; however, there are many differing foam control technologies, including differing silicone technologies. Differentiating foam control performance and use levels requires assessment of foam control additives in various media. It also requires using various techniques, like basic CIPAC manual foam testing, automated shake testing, or high-tech computerized foam analysis. These various foaming tests are used to assess many different foam control technologies. Using the foam assessment tools described, this study shows the performance of various foam control technologies. It also shows the many performance benefits of newly developed silicone foam control technologies for applications in challenging agriculture formulations.
Effect of Spray Solution Recirculation on the Sprayer, Caused by Pumping, on the Droplet Spectra Generated When Spraying Different Solutions
Authors: Antuniassi Ulisses R. , Mota Alisson A. B. , Chechetto Rodolfo G. , Carvalho Fernando K. , Ovejero Ramiro F. L. , Barbosa Henrique N. , Palhano Matheus G. , de Araujo Vitor C. R.
Published: November 2022

The aim of this work was to evaluate the effect of spray solution recirculation on the sprayer, caused by pumping, on the droplet spectra generated when spraying different solutions. A sprayer built to operate with piston or centrifugal pumps was used to simulate different intensities of pumping recirculation, providing 300 kPa to a nozzle inside a spray chamber, where the droplet spectra generated over time were measured by a VisiSize P15 particle analyzer (Oxford Lasers, UK). The volume median diameter (VMD), the percentage by volume composed of droplets smaller than 150 µm (V150), and the relative span (RS) were calculated for TTI 11003 (Spraying Systems Co.) spraying tank mixtures of dicamba and glyphosate: 2.0 L c.p./ha of a formulation of dicamba diglycolamine salt (480 g a.e./L) and 3.0 L c.p./ha of a formulation of glyphosate potassium salt (480 g a.e./L). Four spray solutions were prepared: herbicides alone and mixed with adjuvants based on three technologies: guar gum (0.75% v/v), polymer (0.6% v/v), and methylated seed oil (0.1% v/v). All solutions received 0.5% v/v of a volatility reduction adjuvant. Three recirculation levels were considered: 1.0 to 2.5 cycles, 4.0 to 6.9 cycles, and 16 to 20 cycles (one cycle means that the solution passed through the pump once). The results showed that the polymer adjuvant was more sensitive to the shear caused by recirculation, providing droplet spectra more prone to drift. Other adjuvants had less or no significant interference on their performance after being pumped. Differences between pump types depended on the type of adjuvant.
The role of artificial intelligence in the differential diagnosis of wheezing symptoms in children
Authors: Song Lan , Zhu Zhenchen , Hu Ge , Sui Xin , Song Wei , Jin Zhengyu
Published: November 2022

The incidence of pediatric wheeze is extremely high. Poor control of wheeze in young children affects lung function in adulthood and is closely associated with the occurrence of chronic obstructive pulmonary disease. Substantial efforts worldwide have been aimed at developing methods to identify the etiology of wheezing symptoms as early as possible to aid in early management strategies. However, the diagnosis of childhood wheeze relies heavily on the clinical experience of pediatricians, most of whom lack sufficient training to accurately diagnose children with wheezing symptoms. Artificial intelligence is an approach that may improve general pediatricians’ diagnostic ability for wheezing symptoms by identifying patterns and trends from large and complex clinical datasets. However, few studies have used artificial intelligence to diagnose wheeze in children. Therefore, this review aims to comprehensively assess these studies in this field, analyze their interpretability and limitations, and explore and discuss future research directions in real-world clinical applications.
Sphingosine‐1‐phosphate controls endothelial sphingolipid homeostasis via ORMDL
Authors: Sasset Linda , Chowdhury Kamrul H , Manzo Onorina L , Rubinelli Luisa , Konrad Csaba , Maschek J Alan , Manfredi Giovanni , Holland William L , Di Lorenzo Annarita
Published: November 2022

Disruption of sphingolipid homeostasis and signaling has been implicated in diabetes, cancer, cardiometabolic, and neurodegenerative disorders. Yet, mechanisms governing cellular sensing and regulation of sphingolipid homeostasis remain largely unknown. In yeast, serine palmitoyltransferase, catalyzing the first and rate‐limiting step of sphingolipid de novo biosynthesis, is negatively regulated by Orm1 and 2. Lowering sphingolipids triggers Orms phosphorylation, upregulation of serine palmitoyltransferase activity and sphingolipid de novo biosynthesis. However, mammalian orthologs ORMDLs lack the N‐terminus hosting the phosphosites. Thus, which sphingolipid(s) are sensed by the cells, and mechanisms of homeostasis remain largely unknown. Here, we identify sphingosine‐1‐phosphate (S1P) as key sphingolipid sensed by cells via S1PRs to maintain homeostasis. The increase in S1P‐S1PR signaling stabilizes ORMDLs, restraining SPT activity. Mechanistically, the hydroxylation of ORMDLs at Pro137 allows a constitutive degradation of ORMDLs via ubiquitin‐proteasome pathway, preserving SPT activity. Disrupting S1PR/ORMDL axis results in ceramide accrual, mitochondrial dysfunction, impaired signal transduction, all underlying endothelial dysfunction, early event in the onset of cardio‐ and cerebrovascular diseases. Our discovery may provide the molecular basis for therapeutic intervention restoring sphingolipid homeostasis.
Persepsi Pemandu Wisata Terhadap Kebutuhan Dunia Pariwisata Bahasa Mandarin di Yogyakarta
Authors: Prakosa Renaldo Galang , Marsuki Ria Riski , Supriatnaningsih Rina , Anggraeni Anggraeni
Published: November 2022

Indonesia sebagai negara dengan sumber pendapatan terbesar yang salah satunya dari industri pariwisata, berupaya menjalin kerjasama dengan berbagai negara, salah satunya adalah China. Penelitian ini bertujuan untuk mengetahui persepsi pemandu wisata bahasa mandarin terhadap kebutuhan dunia pariwisata berbahasa mandarin di Yogyakarta dan mengetahui persepsi pemandu wisata terhadap kebutuhan kemampuan bahasa Mandarin. Penelitian ini menggunakan metode penelitian kualitatif-deskriptif. Subjek penelitian ini adalah pemandu wisata Bahasa Mandarin di Yogyakarta. Hasil penelitian skripsi ini adalah (1) persepsi pemandu wisata terhadap kebutuhan dunia pariwisata adalah memiliki kemampuan umum sebagai pemandu wisata.; (2) persepsi pemandu wisata terhadap kebutuhan kemampuan Bahasa mandarin adalah semakin meningkatnya sumber daya manusia yang mampu menggunakan Bahasa Mandarin maka mampu meningkatkan jumlah kunjungan wisatawan yang berkunjung ke Yogyakarta
Nilai Moral Pada Tokoh Utama Dalam Film “Shéi De Qīngchūn Bù Mímáng”
Authors: Lumban Toruan Sutri Sumi , Erwani Intan
Published: November 2022

Judul penelitian adalah “Nilai Moral Pada Tokoh Utama Dalam Film “Shéi de Qīngchūn Bù Mímáng”. Nilai moral merupakan cerminan nilai sikap manusia yang telah diterapkan sejak kecil pada diri seseorang yaitu baik ataupun buruknya. Sebagaimana cerminan nilai moral tersebut dapat dilihat dari perilaku, tindakan dengan melibatkan isi hati dan pemikiran. Sehingga penulis tertarik untuk menganalisis lebih dalam lagi mengenai nilai moral karena nilai moral sangat penting dalam kehidupan manusia sebagai makhluk yang bersosialisasi. Selain itu, penulis memilih nilai moral karena pentingnya nilai moral untuk diterapkan kepada semua orang sehingga terinspirasi akan sikap dari tokoh Lin Tian Jiao yang memiliki sikap nilai moral individual. Tujuan dari penelitian ini adalah mendeskripsikan nilai moral individual yang ditunjukkan oleh tokoh utama dalam film dalam Shéi de Qīngchūn Bù Mímáng. Metode penelitian yang penulis gunakan adalah metode deskriptif kualitatif yang menyajikan data dalam bentuk kalimat. Pengumpulan data menggunakan teknik menonton, menyimak dan mencatat. Berdasarkan hasil penelitian ini menunjukkan tiga bentuk nilai moral individual dalam film. Tiga bentuk nilai moral individual meliputi: nilai moral kejujuran, nilai moral keberanian, dan nilai moral bertanggung jawab.
Pengembangan Modul Apersepsi Untuk Guru Bahasa Mandarin Tingkat Sekolah Dasar
Authors: Farina Silfia , Anggraeni Anggraeni , Supriatnaningsih Rina , Marsuki Ria Riski
Published: November 2022

Penelitian ini didasari oleh adanya permasalahan guru bahasa Mandarin tingkat sekolah dasar yang mengalami kesulitan dalam mengkondisikan kelas agar tercapainya tujuan pembelajaran. Penyebabnya antara lain guru kekurangan sumber informasi tentang apersepsi, yang mana apersepsi merupakan suatu teknik untuk membuka pelajaran dengan cara menarik minat pesera didik sesuai pengalaman peserta didik sehari-hari kedalam proses pembelajaran yang sedang berlangsung sehingga siswa menjadi tidak mudah bosan. Berdasarkan permasalahan tersebut, peneliti berupaya mengembangkan media yang berupa Modul Apersepsi. Tujuan dari penelitian ini, yaitu: 1) Menganalisis kebutuhan guru dan mahasiswa terhadap Modul Apersepsi untuk Guru Bahasa Mandarin Tingkat Sekolah Dasar. 2) Mengetahui prosedur pengembangan Modul Apersepsi untuk Guru Bahasa Mandarin Tingkat Sekolah Dasar. 3) Mengetahui hasil validasi ahli terhadap Modul Apersepsi untuk Guru Bahasa Mandarin Tingkat Sekolah Dasar. Penelitian ini menggunakan metode Research and Development (RD) dengan lima tahapan, yaitu: (1) analisis kebutuhan (2) perancangan desain (3) implementasi desain (4) validasi desain (5) revisi desain. Berdasarkan analisis kebutuhan menunjukkan bahwa guru dan mahasiswa menghendaki adanya pengembangan modul apersepsi yang bervariasi. Hasil validasi oleh ahli materi menunjukkan bahwa Modul Apersepsi untuk Guru Bahasa Mandarin Tingkat Sekolah Dasar mendapat nilai rata-rata keseluruhan 85,8 dengan skor 4, sedangkan validasi oleh ahli media media mendapatkan nilai rata-rata 85,6 dengan skor 4 berarti modul sangat layak digunakan. Modul kemudian diperbaiki sesuai saran yang diberikan para ahli pada aspek-aspek tertentu.
Code-mixing by a content creator Gita Savitri Devi: How and why?
Authors: Perlina Mia , Agustinah Mita
Published: November 2022

Code-mixing, which is the use of two or more languages that are mixed in one utterance, is commonly practiced by bilingual or multilingual people. Then, this study aims to find out the types and the reasons for code-mixing performed by Gita Savitri Devi, a content creator, in one of her videos on YouTube channel entitled "Plis Stop Nyebarin Hoaks!! Beropini Eps. .55". Qualitative descriptive method is used to conduct this study, and the data are analyzed using Hoffman’s theory (1991). The results of this study indicate that there are three types of code-mixing that are found in the video, namely intra sentential code-mixing, intra lexical code-mixing and involving a change of pronunciation. Furthermore, the writers also find three reasons why code-mixing is utilized, among others are: (1) talking about a particular topic; (2) being empathetic or emotional about something; and (3) repetition used for clarification. The existence of code-mixing in our daily life is able to facilitate us to language learning. However, there are still some mistakes in using the language such as dictions and ungrammatical structure. Therefore, we have to be careful in using the language and adjust it with the society to avoid miscommunication.
The representation of Islamic value in government-mandated English language textbook: A critical discourse analysis
Authors: Muslim Baihaqi Zakaria , Putri Dian Natasya , Rizqoh Siti Athur , Basya Dihliza
Published: November 2022

There is a vast amount of English for foreign language (EFL) textbook evaluation studies analyzing multi-dimensional values around the world. However, only a limited number of literature analyzes the Islamic value in EFL Textbooks, especially in Indonesia. To fill this glaring gap, the present critical discourse study aimed to investigate the intrinsic Islamic value contained in Indonesia's government-mandated English textbook for secondary high school students. Halliday’s systemic functional analysis and Kress and Van Leeuwen's visual grammar theory were then conducted to understand, analyze, and explain the content and the picture in the textbook respectively. Compassionate, respect, and care for life in all its forms; solidarity and conflict avoidance; and tolerance for cultures of the different ethnic and religious groups were found to be the major themes of Islamic values emerge from the textbook. Finally, conclusions, limitations, and recommendations were then discussed.
Category shift and its meaning shift in the translation of ANTARA news’ press releases
Authors: Putra Natanael Bania Asaf , Ramadanty Restu Lodyta Ariyana
Published: November 2022

This research aimed to investigate the types, the most dominant types of category shifts, and meaning shifts that occurred in the category shift found in the English to the Indonesian press releases on ANTARA news. The descriptive qualitative was used to investigate the data. The theories were applied, namely Catford (1965) and Simatupang (2000). Furthermore, this research took three samples of the press releases on ANTARA news. The data were taken from looking at the official website of ANTARA news. Then, the data were put in the table consisting of SL and TL. After resolving the analysis of each category shift, the researcher found 306 data. Structure shifts occurred to the number of 139 data or 45 %, intra-system shifts were 85 data or 28 %, unit shifts were 72 data or 24 %, and class shifts occurred are 10 data or 3 %. The most dominant category shift was structure shift. Furthermore, the result of meaning shifts, there were 300 data or 98% for no meaning shift. The result of the specific to generic and vice versa as well as the cultural point of view had 3 data or 1% for each type.
Finnish-specific AKT2 gene variant leads to impaired insulin signalling in myotubes
Authors: Mäkinen Selina , Datta Neeta , Rangarajan Savithri , Nguyen Yen H , Olkkonen Vesa M , Latva-Rasku Aino , Nuutila Pirjo , Laakso Markku , Koistinen Heikki A
Published: November 2022

Finnish-specific gene variant p.P50T/AKT2 (minor allele frequency (MAF) = 1.1%) is associated with insulin resistance and increased predisposition to type 2 diabetes. Here, we have investigated in vitro the impact of the gene variant on glucose metabolism and intracellular signalling in human primary skeletal muscle cells, which were established from 14 male p.P50T/AKT2 variant carriers and 14 controls. Insulin-stimulated glucose uptake and glucose incorporation into glycogen were detected with 2-[1,2-3H]-deoxy-D-glucose and D-[14C]-glucose, respectively, and the rate of glycolysis was measured with a Seahorse XFe96 analyzer. Insulin signalling was investigated with Western blotting. The binding of variant and control AKT2-PH domains to phosphatidylinositol (3,4,5)-trisphosphate (PI(3,4,5)P3) was assayed using PIP StripsTM Membranes. Protein tyrosine kinase and serine-threonine kinase assays were performed using the PamGene® kinome profiling system. Insulin-stimulated glucose uptake and glycogen synthesis in myotubes in vitro were not significantly affected by the genotype. However, the insulin-stimulated glycolytic rate was impaired in variant myotubes. Western blot analysis showed that insulin-stimulated phosphorylation of AKT-Thr308, AS160-Thr642 and GSK3β-Ser9 was reduced in variant myotubes compared to controls. The binding of variant AKT2-PH domain to PI(3,4,5)P3 was reduced as compared to the control protein. PamGene® kinome profiling revealed multiple differentially phosphorylated kinase substrates, e.g. calmodulin, between the genotypes. Further in silico upstream kinase analysis predicted a large-scale impairment in activities of kinases participating, for example, in intracellular signal transduction, protein translation and cell cycle events. In conclusion, myotubes from p.P50T/AKT2 variant carriers show multiple signalling alterations which may contribute to predisposition to insulin resistance and T2D in the carriers of this signalling variant.
Improving biorefinery sustainability and profitability by cultivating aquatic plants on ozonized distillery effluents
Authors: Dziugan Piotr , Romanowska-Duda Zdzisława , Piotrowski Krzysztof , Cieciura-Wloch Weronika , Antolak Hubert , Smigielski Krzysztof , Binczarski Michał , Witonska Izabela , Domański Jarosław
Published: November 2022

Industrial production of biogas offers a way to manage distillery leachate. The waste is usually subjected to anaerobic digestion for producing biogas. However, the effluent from anaerobic processes has high chemical oxygen demand (COD) and is harmful to the environment. An effective method of lowering COD is ozonation. Effluent from biogas plants after ozonation has the potential for use in breeding grounds for plants of the Lemnaceae family. Thus, they can provide a valuable additional source of biomass for the production of bioethanol. Lemna minor L. and Spirodela polyrhiza cultures were grown in media with the addition of 2.5% PFE, which had been treated by ozonation for between 6 and 50 min. Using ozonated effluent was an effective cultivation technique in all variants. The analyzed parameters were plant growth, chlorophyll index, fresh plant weight and photosynthetic traits (net photosynthesis, stomatal conductance, transpiration and concentration of intercellular CO2). The best growth of Lemna minor L. was observed in the media with PFE treated for 12 min. Similar effects were obtained for S. polyrhiza, with ozone treatment for 12 and 25 min. The results show the potential of using ozone-treated post-fermentation leachate as a supplement in culture media.
Identifying and ranking components of manufacturing sustainability in the Iranian papermaking industry
Authors: Mohammadi Nematabad Sina , Pourmousa Shademan , Tajdini Ajang , Jahan Latibari Ahmad , Lashgari Amir
Published: November 2022

Factors of manufacturing sustainability in the papermaking industry were identified and ranked using qualitative analysis and nonparametric tests. Based on a review of the literature on sustainable development and production, seven main factors of economic, environmental, technological, social, human, material and product, and regulations were identified to underpin the manufacturing sustainability in the papermaking industry, as well as some sub-factors. Then, a self-designed questionnaire was developed to take a poll among papermaking managers and experts regarding the effectiveness of the factors and sub-factors in manufacturing sustainability and their status. The factors affecting manufacturing sustainability in the papermaking industry were confirmed by the standard and significance coefficients in the structural equations and the predictive criterion. The cross-validated redundancy index showed that the data were valid enough for prediction. The research factors were ranked by the ordinal average affecting sustainability, current status, and distance to sustainability. The materials and product, environmental, technological, and economic factors had the greatest influence on manufacturing sustainability, and the regulation and human factors had the highest distance to sustainability. To achieve manufacturing sustainability in the papermaking industry, regulations and human factors need to be further studied. Their improvement has potential to achieve manufacturing sustainability.
Discrete element method for simulation and calibration of cotton stalk contact parameters
Authors: Li Jiali , Lu Yongtao , Peng Xiangbin , Jiang Peng , Zhang Bingcheng , Zhang Lanyu , Meng Hewei , Kan Za , Wang Xinzhong
Published: November 2022

To improve the accuracy of the discrete element research, physical and simulation experiments were used to calibrate the cotton stalk contact parameters. Based on the stalk-stalk and stalk-steel contact mechanics, the parameters were measured in physical experiments, and the discrete element simulation software was used to build the stalk model. In the simulation process, the Plackett-Burman experiment was used to screen three significant factors from six initial factors. The steepest Plackett-Burman experiment was used to determine the optimal interval of the significant factors. A second-order regression model of the significant factors and the angle of repose was established according to the Central Composite design experiment. The best parameter combination of the significant factors was then obtained: the coefficient of static friction on stalk-steel contact was 0.31, the coefficient of static friction on stalk-stalk contact was 0.62, and the coefficient of rolling friction on stalk-stalk contact was 0.02. The relative error between the physical angle of repose and the simulated angle was 3.27%, indicating that it is feasible to apply the simulation experiment instead of the physical one. It offers insights into cotton stalk contact parameter settings and film-stalk separation in the simulation.
Providing a Primary Care Medical Home for Children and Youth With Cerebral Palsy
Authors: Noritz Garey , Davidson Lynn , Steingass Katherine ,   the Council on Children with Disabilities, The American Academy For Cerebral Palsy And Developmental Medicine, Noritz Garey , Agrawal Rishi , Ellerbeck Kathryn A. , Foster Jessica E. A. , Fremion Ellen , Frierson Sheryl , Leppert Mary O’Connor , Saunders Barbara S , Stille Christopher , Vargus-Adams Jilda , Zuckerman Katharine , Davidson Lynn , Norwood Kenneth , Yin Larry , Kuo Dennis Z. , Ware Allysa , Mann Marie Y , Sadof Matthew , Poon Jennifer , Yeargin-Allsopp Marshalyn , Kuznetsov Alexandra , Brandenburg Joline E. , Glader Laurie J. , Shrader M. Wade , Wagester Tamara
Published: November 2022

Cerebral palsy (CP) is the most common motor disorder of childhood, with prevalence estimates ranging from 1.5 to 4 in 1000 live births. This clinical report seeks to provide primary care physicians with guidance to detect children with CP; collaborate with specialists in treating the patient; manage associated medical, developmental, and behavioral problems; and provide general medical care to their patients with CP.