bluuebunny/crossref_metadata_2025 huggingface dataset:
Petrographic and Geotechnical Features of Dir Volcanics as Dimension Stone, Upper Dir, North Pakistan
Authors: Nawaz Muhammad , Ahmed Waqas , Yasir Muhammad , Islam Ihtisham , Janjuhah Hammad Tariq , Kontakiotis George , Antonarakou Assimina , Stouraiti Christina
Published: July 2023

The utilization of dimension stone in construction has been prevalent since ancient times; however, its application in modern construction has gained significant attention over the last few decades. This research aimed to assess the physical and strength properties of volcanic rocks from the Kohistan Island Arc for their potential use as dimension stone. Five types of andesites (MMA, PMA-1, PMA-2, CMA, and FMA) and two types of agglomerates (AG-1 and AG-2) were identified based on their composition, color, and texture. The samples were characterized in terms of their petrography (compositional and textural), physical properties (specific gravity, water absorption, and porosity), and strength properties (unconfined compressive strength and unconfined tensile strength). Two non-destructive tests (ultrasonic pulse velocity test and Schmidt hammer) were conducted, and the degree of polishing was evaluated. Correlation analyses were carried out to establish possible relationships among these parameters. The presence of chlorite, epidote, sericite, and recrystallized quartz indicated signs of low-grade metamorphism in andesites. The study revealed that feldspar, amphibole, and quartz imparted good physical and strength properties to samples MMA, CMA, FMA, AG1, and AG2. On the other hand, PMA-1 and PMA-2 exhibited reduced physical and strength properties due to the abundance of alteration products like chlorite, sericite, and epidote. The unconfined compressive strength exhibited a strong correlation with ultrasonic pulse velocity, skeletal density, porosity, and water absorption. Weathering grade considerably affected the values of ultrasonic pulse velocity and Schmidt hammer. Consequently, samples PMA-1 and PMA-2 are not recommended for load-bearing masonry units and outdoor applications due to their high water absorption and low strength values. On the other hand, samples FMA and MMA exhibited excellent properties like high strength and good polishing, indicating their potential use as decorative and facing stones, external pavement, ashlar, rubbles, and load-bearing masonry units.
Reimagining the Role of Health Departments and Their Partners in Addressing Climate Change: Revising the Building Resilience against Climate Effects (BRACE) Framework
Authors: Lemon Stephenie C. , Joseph Heather A. , Williams Samantha , Brown Claudia , Aytur Semra , Catalano Katherine , Chacker Stacey , Goins Karin V. , Rudolph Linda , Whitehead Sandra , Zimmerman Sara , Schramm Paul J.
Published: July 2023

Public health departments have important roles to play in addressing the local health impacts of climate change, yet are often not well prepared to do so. The Climate and Health Program (CHP) at the Centers for Disease Control and Prevention (CDC) created the Building Resilience Against Climate Effects (BRACE) framework in 2012 as a five-step planning framework to support public health departments and their partners to respond to the health impacts of climate change. CHP has initiated a process to revise the framework to address learnings from a decade of experience with BRACE and advances in the science and practice of addressing climate and health. The aim of this manuscript is to describe the methodology for revising the BRACE framework and the expected outputs of this process. Development of the revised framework and associated guidance and tools will be guided by a multi-sector expert panel, and finalization will be informed by usability testing. Planned revisions to BRACE will (1) be consistent with the vision of Public Health 3.0 and position health departments as “chief health strategists” in their communities, who are responsible for facilitating the establishment and maintenance of cross-sector collaborations with community organizations, other partners, and other government agencies to address local climate impacts and prevent further harm to historically underserved communities; (2) place health equity as a central, guiding tenet; (3) incorporate greenhouse gas mitigation strategies, in addition to its previous focus on climate adaptation; and (4) feature a new set of tools to support BRACE implementation among a diverse set of users. The revised BRACE framework and the associated tools will support public health departments and their partners as they strive to prevent and reduce the negative health impacts of climate change for everyone, while focusing on improving health equity.
Beyond Access: Can a School Health Initiative Facilitate Healthcare Services Utilisation for School-Going Children?
Authors: Babatunde Gbotemi Bukola , Akintola Olagoke
Published: July 2023

Accessing quality healthcare services is critical to addressing the different health challenges confronting school-going children, especially those in low-resource communities. However, the evidence of access to services is utilisation and not the mere availability of such services. This study explored caregivers’ descriptions of the factors influencing the access and utilisation of quality healthcare services for school-going children and their perceptions of the services provided through the integrated school health programme in South Africa. Qualitative interviews were conducted with 17 caregivers of school-going children in three low-resource communities of KwaZulu-Natal province. The data was analysed using thematic analysis, and the themes were clustered using components of the Aday and Andersen framework for access. Despite the efforts to expand the coverage and range of services provided through the Integrated School Health Programme (ISHP), we identified various factors that undermine the overall aim of the ISHP. Financial constraints, distance to health facilities, poor communication and information dissemination systems, low literacy levels, healthcare workers’ negative attitudes, and long waiting periods at the referral sites constitute barriers to service utilisation. Specific attention should be paid to improving the communication system between the school-health team and the caregivers, providing support for transportation, improving the attitude of the clinic staff, and providing follow-up services for children referred for further screening and treatment.
Recent Advances in Breast Cancer Research
Authors: Grimm Daniela
Published: July 2023

This Special Issue (SI), titled “Recent Advances in Breast Cancer Research”, covers 12 research articles and 1 communication in the field of breast cancer (BC) research [...]
Genetic Effects Analysis of QTLs for Rice Grain Size Based on CSSL-Z403 and Its Dissected Single and Dual-Segment Substitution Lines
Authors: Xu Guangyi , Deng Keli , Yu Jinjin , Li Qiaolong , Li Lu , Xiang Aoni , Ling Yinghua , Zhang Changwei , Zhao Fangming
Published: July 2023

Rice chromosomal segment substitution lines (CSSLs) are ideal materials for studying quantitative traits such as grain size. Here, a rice large-grain CSSL-Z403 was identified among progeny of the recipient Xihui18 and the donor Jinhui35 based on molecular marker-assisted selection. Z403 carried 10 substitution segments with average length of 3.01 Mb. Then, a secondary F2 population derived from a cross between Xihui18 and Z403 was used to map quantitative trait loci (QTL) for grain size. Six QTLs distributed on chromosomes 5, 6, 7, 9 and 12 were detected. Finally four single-segment substitution lines (SSSLs) and two dual-segment substitution lines (DSSLs) carrying these target QTLs were constructed, and 10 novel QTLs were identified by four SSSLs. The large grain of Z403 was controlled at least by qGWT5, qGWT7, qGWT9 and qGWT12, and its grain weight was influenced through grain length QTL such as qGL5, qGL6, qGL9 and qGL12, as well as grain width QTL such as qGW5, qGW7, qGW9 and qGW12. Among 16 QTLs, four QTLs including qGL6, etc., might be novel compared with the reported documents. Again, positive or less negative epistatic effects between two non-allelic QTLs (additive effect > 0) may assist screening the genotype with larger grain size in further selection.
Enhancing Healthcare Management during COVID-19: A Patient-Centric Architectural Framework Enabled by Hyperledger Fabric Blockchain
Authors: Khatri Sabita , al-Sulbi Khalil , Attaallah Abdulaziz , Ansari Md Tarique Jamal , Agrawal Alka , Kumar Rajeev
Published: July 2023

The highly transmissible COVID-19 virus has wreaked havoc on the global economy, health, and lives. The abrupt burst and exponential spread of this pandemic has shown the inadequacies of existing healthcare institutions in handling a public health emergency. As governments around the world strive to re-establish their economies, open workplaces, ensure safe journeys, and return to regular life, they require solutions to reduce losses. The proposed framework provides virtual assistance from various medical practitioners and physicians. Furthermore, it promotes the accuracy of information gathered from COVID-19 patients, which can aid in the launch of a variety of government decisions and public guidelines aimed at combating health exigencies. The authors present a revolutionary blockchain-based solution that builds trust between the medical professionals and patients while preventing accidental coronavisrus transmission. This solution also keeps track of COVID-19 patients and improves EHR management, which can be a viable solution for common EHR challenges such as lowering the risk of patient data loss, maintaining privacy and security, and obtaining immutable consensus on the maintenance of health records, gaps in hospital communication, and inefficient clinical data retrieval methods. This research work describes a COVID-19 patient-centric blockchain-based EHR employing JavaScript-based smart contracts for a decentralized healthcare management system. The proposed Hyperledger fabric and a Composer-based working prototype ensure the model’s security and the authenticity of the health records. The authors used the Hyperledger Caliper benchmarking tool, which measures latency, throughput, resource utilization, etc., under different conditions and control parameters. The findings highlight the importance of the proposed blockchain-enabled architecture in revolutionizing healthcare administration during and after the COVID-19 pandemic, promoting enhanced clinical outcomes and supporting patient-centered care.
The Differences in the Pattern of OCT and OCTA Examinations between Early Normal- and High-Tension Pseudoexfoliative Glaucoma
Authors: Łukasik Urszula , Wróbel-Dudzińska Dominika , Jarecki Jaromir , Gasińska Karolina , Żarnowski Tomasz , Święch Anna , Kosior-Jarecka Ewa
Published: July 2023

Purpose. The aim of this study was to compare the results of optical coherence tomography angiography (OCTA) and optical coherence tomography (OCT) examinations in patients with normal-tension glaucoma (NTG) in comparison to high-tension pseudoexfoliative glaucoma (HTG) patients at the early stage of glaucoma. Material and methods. The studied groups consisted of patients in the early stage of NTG (70 eyes) and the early stage of HTG (71 eyes). In NTG and HTG groups, a detailed ophthalmic examination was performed. Optic disc OCT with peripapillary RNFL measurements and OCTA examination with the evaluation of the macula and optic disc were performed for all participants using Zeiss Cirrus 5000. Results. NTG and HTG groups were statistically similar as far as the MD was concerned, and both groups had early glaucoma. When evaluating the RNFL thickness, the only statistical difference between early NTG and HTG was observed in the thicknesses in the temporal sector of peripapillary RNFL, with thinner values in the NTG group (53.94 vs. 59.94, p = 0.0071). When the OCTA results of the macula and optic disc were evaluated, there were no statistical differences between early NTG and HTG. Conclusions. The vascular density and flow parameters assessed in OCTA were equal between early NTG and HTG, and therefore the involvement of vascular factors in NTG pathogenesis could not be confirmed. Our results confirm the preponderance of more frequent temporal RNFL involvement in early NTG.
Nusinersen Treatment of Children with Later-Onset Spinal Muscular Atrophy and Scoliosis Is Associated with Improvements or Stabilization of Motor Function
Authors: Dunaway Young Sally , Montes Jacqueline , Glanzman Allan M. , Gee Richard , Day John W. , Finkel Richard S. , Darras Basil T. , De Vivo Darryl C. , Gambino Giulia , Foster Richard , Wong Janice , Garafalo Steve , Berger Zdenek
Published: July 2023

Nusinersen has been shown to improve or stabilize motor function in individuals with spinal muscular atrophy (SMA). We evaluated baseline scoliosis severity and motor function in nusinersen-treated non-ambulatory children with later-onset SMA. Post hoc analyses were conducted on 95 children initiating nusinersen treatment in the CHERISH study or SHINE long-term extension trial. Participants were categorized by baseline Cobb angle (first nusinersen dose): ≤10°, >10° to ≤20°, and >20° to <40° (no/mild/moderate scoliosis, respectively). Outcome measures included the Hammersmith Functional Motor Score—Expanded (HFMSE) and the Revised Upper Limb Module (RULM). Regression analysis determined the relationships between baseline scoliosis severity and later motor function. For children with no, mild, and moderate scoliosis, the mean increase in HFMSE from baseline to Day 930 was 6.0, 3.9, and 0.7 points, and in RULM was 6.1, 4.6, and 2.3 points. In the linear model, a 10° increase in baseline Cobb angle was significantly associated with a −1.4 (95% CI −2.6, −0.2) point decrease in HFMSE (p = 0.02) and a −1.2 (95% CI −2.1, −0.4) point decrease in RULM (p = 0.006) at Day 930. Treatment with nusinersen was associated with improvements/stabilization in motor function in all groups, with greater response in those with no/mild scoliosis at baseline.
Impact of Estimated Left Atrial Pressure on Cardiac Resynchronization Therapy Outcome
Authors: Beela Ahmed S. , Manetti Claudia A. , Lyon Aurore , Prinzen Frits W. , Delhaas Tammo , Herbots Lieven , Lumens Joost
Published: July 2023

Background: We investigated the impact of baseline left atrial (LA) strain data and estimated left atrial pressure (LAP) by applying the 2016 American Society of Echocardiography and the European Association of Cardiovascular Imaging (ASE/EACVI) guidelines on cardiac resynchronization therapy (CRT) outcomes. Methods: Datasets of 219 CRT patients were retrospectively analysed. All patients had full echocardiographic diastolic function assessment before CRT and were classified based on the guideline algorithm into normal LAP (nLAP = 40%), elevated LAP (eLAP = 49%) and indeterminate LAP (iLAP = 11%). All relevant baseline characteristics were analysed. CRT-induced left ventricular (LV) reverse remodeling was measured as the relative change of LV end-systolic volume (LVESV) at 12 ± 6 months after CRT compared to baseline. Patients were followed up for all-cause mortality for a mean of 4.8 years [interquartile range (IQR): 2.7–6.0 years]. Results: At follow-up, CRT resulted in more pronounced reduction of LVESV in patients with nLAP than in patients with eLAP. In univariate analysis, nLAP was associated with LV reverse remodelling (p < 0.001), as well as long-term survival after CRT (p < 0.01). However, multivariable analysis showed that only the association between nLAP and LV reverse remodelling after CRT is independent (p < 0.01). Adding LA strain analysis to the guideline algorithm improved the feasibility of LAP estimation without affecting the association between estimated LAP and CRT outcome. Conclusion: Normal LAP before CRT, estimated using the 2016 ASE/EACVI guideline algorithm, is associated with LV reverse remodelling and long-term survival after CRT. Albeit non-independent, it can serve as a non-invasive imaging-based predictor of effective therapy. Furthermore, the inclusion of LA reservoir strain in the guideline algorithm can enhance the feasibility of LAP estimation without affecting the association between LAP and CRT outcome.
Detecting Comparative Features of Comprehensive Geriatric Assessment through the International Classification of Functioning, Disability, and Health Linkage: A Web-Based Survey
Authors: Tomita Naoki , Ohashi Yuki , Ishiki Aiko , Ozaki Akiko , Nakao Mitsuyuki , Ebihara Satoru , Taki Yasuyuki
Published: July 2023

Multidimensional assessments are important in evaluating the overall health of older adults. The comprehensive geriatric assessment (CGA) is a representative framework; however, the burden associated with the CGA has led to the development of simplified multidimensional tools. Comparing these tools to the CGA can help utilize them effectively. However, a direct comparison is challenging owing to the conceptual nature of the CGA. In this study, we conducted a web-based survey to identify essential CGA components by linking International Classification of Functioning, Disability, and Health (ICF) category level 2 items and “not defined/not covered” (nd/nc) items. Healthcare professionals and individuals aged >65 years participated in a two-stage Delphi study. In total, 182 respondents (7 geriatricians, 22 nurses, 20 therapists, and 4 case managers) completed the survey. Sixty-one essential components for CGA were identified, including 55 ICF categories. Additionally, personal factors (i.e., proactiveness) and nd/nc items (i.e., subjective perceptions) were aggregated. The results suggest that the CGA includes objective conditions of intrinsic capacity, functional ability, and environment as well as subjective perceptions and proactiveness toward those conditions. Thus, CGA is not merely expected to assess geriatric syndrome but also to estimate broader concepts, such as interoception, resilience, and quality of life.
The Beginning of an ECLS Center: First Successful ECPR in an Emergency Department in Romania—Case-Based Review
Authors: Nedelea Paul Lucian , Manolescu Emilian , Ciumanghel Adi-Ionut , Constantin Mihai , Hauta Alexandra , Sirbu Oana , Ionescu Lidia , Blaj Mihaela , Corlade-Andrei Mihaela , Sorodoc Victorita , Cimpoesu Diana
Published: July 2023

According to the latest international resuscitation guidelines, extracorporeal cardiopulmonary resuscitation (ECPR) involves the utilization of extracorporeal membrane oxygenation (ECMO) in specific patients experiencing cardiac arrest, and it can be considered in situations where standard cardiopulmonary resuscitation efforts fail if they have a potentially reversible underlying cause, among which we can also find hypothermia. In cases of cardiac arrest, both witnessed and unwitnessed, hypothermic patients have higher chances of survival and favorable neurological outcomes compared to normothermic patients. ECPR is a multifaceted procedure that requires a proficient team, specialized equipment, and comprehensive multidisciplinary support within a healthcare system. However, it also carries the risk of severe, life-threatening complications. With the increasing use of ECPR in recent years and the growing number of centers implementing this technique outside the intensive care units, significant uncertainties persist in both prehospital and emergency department (ED) settings. Proper organization is crucial for an ECPR program in emergency settings, especially given the challenges and complexities of these treatments, which were previously not commonly used in ED. Therefore, within a narrative review, we have incorporated the initial case of ECPR in an ED in Romania, featuring a successful resuscitation in the context of severe hypothermia (20 °C) and a favorable neurological outcome (CPC score of 1).
Paternal Age Matters: Association with Sperm Criteria’s- Spermatozoa DNA Integrity and Methylation Profile
Authors: Lahimer Marwa , Montjean Debbie , Cabry Rosalie , Capelle Severine , Lefranc Elodie , Bach Véronique , Ajina Mounir , Ben Ali Habib , Khorsi-Cauet Hafida , Benkhalifa Moncef
Published: July 2023

Advanced age has been reported to negatively affect sperm parameters and spermatozoa DNA integrity. A decline in sperm criteria was also associated with altered epigenetic marks such as DNA methylation with a potential downstream impact on in vitro fertilization success and clinical outcomes. The aim of the present retrospective study was to clarify the association between advanced paternal age (APA) and sperm parameters, DNA integrity and DNA methylation profile. A total of 671 patients consulting for infertility underwent sperm analysis, sperm DNA integrity assessment and methylation level measurement. The principal finding was that individuals over 40 years of age exhibit a significant increase in DNA fragmentation levels compared to the younger group (15% versus 9%, respectively, p = 0.04). However, there was no significant difference in DNA decondensation and sperm parameters in association with APA. In addition, a drop in the global methylation level was also found in men over 40 years (6% in the young group versus 2% in the old group, p = 0.03). As a conclusion, men over 40 years are at higher risk of elevated sperm DNA fragmentation and lower methylation level. Based on these observations, it is recommended that the assessment of sperm DNA fragmentation should be taken into consideration particularly after the age of 40. Our findings support the idea that paternal age is a crucial factor that should not be neglected during fertility evaluation and treatment since it is associated with epigenetics changes in sperm. Although the underlying mechanism remains to be clarified, we believe that environmental and professional exposure factors are likely involved in the process.
Fungicidal and Stimulating Effects of Heteroleptic Copper Complex on the Germination and Phytosafety of Plants
Authors: Kabdrakhmanova Sana , Kabdrakhmanova Ainur , Shaimardan Esbol , Akatan Kydyrmolla , Beisebekov Madiar , Hryhorchuk Natalia , Selenova Bagadat S. , Joshy K. S. , Thomas Sabu
Published: July 2023

At present, when the whole world is intensively switching to organic farming, the refusal or minimization of the usage of chemical plant protection products and synthesized fertilizers is a very urgent issue for the agro-industrial complex (AIC). Accordingly, the solution to the problems of increasing yields and ensuring the fight against pathogenic components should be carried out in accordance with the principles of “green” chemistry. In this regard, the usage of heteroleptic complexes based on carboxylic and amino acids with biogenic metals is dictated not only by their availability, low cost, and ability to increase crop yields but also by fungicidal activity, lower toxicity, and easy biodegradability, which lists them among the “green” and cost-effective plant biostimulants. In the present work, for the first time, a heteroleptic complex based on succinic acid and glycine, with the formula [Cu(succ)(gly)], was developed for usage as a fungicidal biostimulant, which has the ability to significantly reduce the number of pathogens. We found that this compound has a layered structure and was able to increase soybean germination up to 100%.
Infotainers, Mediators, or Watchdogs? Mapping the Field of News Podcasters and Their Role Conceptions in Germany, Austria, and Switzerland
Authors: Katzenberger Vera , Schützeneder Jonas , Grassl Michael , Keil Jana
Published: July 2023

News podcasts have emerged as a relevant medium, contributing to the collection, analysis, interpretation, and dissemination of information in mass media discourse. This paper presents an analysis of the sociodemographic backgrounds, professional profiles, role perceptions, and values of news podcasters based on an online survey of 195 participants in Austria, Germany, and Switzerland. The results reveal that news podcasters are predominantly male, middle-aged, and academically educated with no journalistic socialization or journalistic working experience. In terms of self-images and values, news podcasters emphasize the importance of education, information, and entertainment, while rejecting conventional concepts like criticism and control. Overall, they demonstrate a strong orientation towards the needs of their audiences and strive to be responsive to their preferences. Yet, the monetization of content through financing models such as sponsoring or native advertisement is not established on a broad scale. These findings shed light on the unique characteristics of news podcasters and provide insights into their status in a rapidly changing media environment.
Evaluation of Plasma miR-17-5p, miR-24-3p and miRNA-223-3p Profile of Hepatitis C Virus-Infected Patients after Treatment with Direct-Acting Antivirals
Authors: Öksüz Zehra , Gragnani Laura , Lorini Serena , Temel Gülhan Örekici , Serin Mehmet Sami , Zignego Anna Linda
Published: July 2023

The expression of miR-223-3p, miR-17-5p, and miR-24-3p was evaluated in hepatitis C virus (HCV) patient serum samples, collected before DAA treatment and after a sustained virological response (SVR). Fifty HCV patients were stratified based on their liver damage stages into three different subgroups (21 with chronic hepatitis—CH, 15 with cirrhosis, and 14 with hepatocellular carcinoma—HCC). Considering the entire HCV population, the miRNA expression levels were significantly downregulated after the SVR compared to pre-treatment ones (p < 0.05). Stratifying the patients based on liver damage, the post-SVR values of the three miRNAs were significantly downregulated compared to the pre-treatment levels for both cirrhosis and HCC patients. No significant differences emerged from the analysis of the CH group. To our knowledge, this is the first study to detail the behavior of miR-223-3p, miR-17-5p, and miR-24-3p levels in patients with HCV-related CH, cirrhosis, and HCC after DAA therapy. Our findings show that HCV-infected patients have different miRNA profiles before and after treatment with DAAs, strongly suggesting that miRNAs may be involved in the pathogenesis of HCV-related damage. In this respect, the correlation observed among the three studied miRNAs could imply that they share common pathways by which they contribute the progression of HCV-induced chronic liver damage.
Special Issue: “Genetic Counseling and Genetic Testing in Precision Medicine”
Authors: Turbitt Erin , Jacobs Chris , McEwen Alison
Published: July 2023

Progress in genomic technologies has spurred innovation in healthcare and medicine, contributing to improved health and well-being [...]
Culture and Corporate Decarbonization Efforts: A Time-Varying Analysis and Topology Approach
Authors: Chen Lingju , Jiang Jiancheng , Yu Sha
Published: July 2023

This study examines the influence of culture on corporate responses to climate change. Given the inherent uncertainty associated with climate change, cultural values, as a non-market force, are expected to impact corporate’s decision making regarding decarbonization.To investigate this, a sample of large firms from 23 societies participating in the Carbon Disclosure Project (CDP) survey was analyzed, along with cultural measures assessed by the Global Leadership and Organizational Behavior Effectiveness (GLOBE) study. The findings of this study reveal that cultural values have diverse effects on corporate decarbonization efforts. Specifically, a preference for avoiding uncertainty and a future-oriented perspective tend to foster decarbonization, while a strong focus on performance appears to hinder such efforts. Additionally, the relationship between culture and decarbonization demonstrates a time-varying characteristic, indicating the influence of culture on carbon performance is contingent upon the evolution of carbon-related institutions over the study period.
Restoration of Grassland Improves Soil Infiltration Capacity in Water-Wind Erosion Crisscross Region of China’s Loess Plateau
Authors: Ren Xiuzi , Chai Xiaohong , Qu Yuanyuan , Xu Yuanhui , Khan Farhat Ullah , Wang Junfeng , Geming Palixiati , Wang Weiwei , Zhang Qi , Wu Qinxuan , Xu Xuexuan , Du Feng
Published: July 2023

Soil water infiltration is a key mechanism for meeting plant water demand and groundwater recharge cycles; however, unreasonable land use practices cause reduced infiltration capacity and greater soil erosion. To date, differences in the properties of aeolian sandy soil and Pisha sandstone soil under different utilization methods as well as in soil properties, aggregates, and infiltration among kind of soil types, remain poorly understood. In this work, 54 soil samples of cropland and grassland were selected to identify the unique characteristics of soil infiltration processes under transition from cropland to grassland and contributions of soil properties to soil infiltrability in the Loess Plateau of China. The results showed that converting cropland to grassland could enhance the stable infiltration capacity of shallow soils of aeolian sandy soil and loess soil by 43.6% and 35.7%, respectively. Compared with cropland, the root properties and soil aggregate formation of the three soil types increased during grassland use, with the largest increase in soil organic matter content (32.14%) and total porosities (6.4%). As determined by the ring knife method, the saturated infiltration capacity of Pisha sandstone soil was significantly lower than in aeolian sandy soil and loess soil (p < 0.5). Moreover, its saturated infiltration capacity of cropland was better than grassland. Spearman’s correlation analysis and structural equation modeling (SEM) revealed that soil infiltration capacity appeared to be the most influenced by soil organic matter, and aggregate structure. These results highlight that fifteen years of returning cropland to grassland is not enough to affect the infiltration ability of deep soil (≥20 cm), and this improvement requires longer term maintenance.
The Impact of Urban Built Environments on Elderly People’s Sense of Safety and Adaptation to Aging: A Case Study of Three Major Urban Agglomerations in China
Authors: Lu Junyu , Dai Meilin , Li Fuhan , Qin Ludan , Cheng Bin , Li Zhuoyan , Yao Zikun , Wu Rong
Published: July 2023

Against the backdrop of accelerating population aging and scarce elderly care resources and facilities in China, the issue of the sense of safety among the elderly has received widespread attention. This article is based on data from the China Labor Force Dynamics Survey (CLDS) in 2016 and takes three major urban agglomerations as examples to examine the impact mechanisms of urban built environments on elderly people’s sense of safety. The results indicate that the characteristics of the urban built environment, the social environment, and individual health affect the safety perceptions of the elderly. Among them, urbanization rate, hospital facilities, population density, greening rate, air quality, and frequency of dining out have significant impacts on elderly people’s sense of safety. Simultaneously, good daily exercise and mental health status can significantly improve elderly people’s sense of safety. This article summarizes the existing problems of aging-friendly spaces and facilities in three major urban agglomerations, proposes planning strategies to enhance elderly people’s sense of safety, and provides a useful reference for urban aging-friendly transformations and an elderly-friendly society.
The Viral Knock: Ameliorating Cancer Treatment with Oncolytic Newcastle Disease Virus
Authors: Pathak Upasana , Pal Ramprasad B. , Malik Nagesh
Published: July 2023

The prospect of cancer treatment has drastically transformed over the last four decades. The side effects caused by the traditional methods of cancer treatment like surgery, chemotherapy, and radiotherapy through the years highlight the prospect for a novel, complementary, and alternative cancer therapy. Oncolytic virotherapy is an evolving treatment modality that utilizes oncolytic viruses (OVs) to selectively attack cancer cells by direct lysis and can also elicit a strong anti-cancer immune response. Newcastle disease virus (NDV) provides a very high safety profile compared to other oncolytic viruses. Extensive research worldwide concentrates on experimenting with and better understanding the underlying mechanisms by which oncolytic NDV can be effectively applied to intercept cancer. This review encapsulates the potential of NDV to be explored as an oncolytic agent and discusses current preclinical and clinical research scenarios involving various NDV strains.
Molecular Detection and Characterization of Ehrlichia canis Isolates from Three Geographic Regions in Mexico: A Retrospective Study
Authors: Lira-Amaya José Juan , Beristain-Ruiz Diana M. , Racanco-Delgado Jesús , Garza-Hernández Javier A. , Vital-García Cuauhcihuatl , Santamaria-Espinosa Montserrat , Martínez-García Grecia , Alvarez-Martínez Antonio , Quezada-Casasola Andrés , Rojas-Martínez Carmen , Alvarado-Robles Beatriz , Figueroa-Millán Julio V.
Published: July 2023

Canine monocytic ehrlichiosis (CME) is the most common tick-borne disease affecting domestic dogs and other wild canids. It has a worldwide distribution and is associated with the presence of the brown dog tick. Few studies have been conducted in Mexico to identify and characterize Ehrlichia canis genetic variability. In the present study, 111 dogs of different sex, breed, and age from three geographic regions in Mexico were included. All of them had a previous history of tick infestation and/or the presence of one or more clinical signs compatible with CME. All dogs were tested by a commercial ELISA and nested PCR assay for the detection of E. canis. In addition, we analyzed the E. canis genetic diversity from the 16S rRNA gene sequences obtained in this study, along with 15 additional sequences described for E. canis in Mexico and obtained from GeneBank. Serological detection by commercial ELISA results showed overall infection rates of 85.58% (95/111), including 73.1% (30/41) in samples from Guerrero state; 75% (15/20) in Morelos; and 100% (50/50) in Chihuahua. On the other hand, molecular detection (nPCR assay) showed 31.5% (35/111) overall infection rate, with 41.4% (17/41) in Guerrero state; 55% (11/20) in Morelos; and 14% (7/50) in Chihuahua. We observed a high 16S rRNA gene sequence conservancy in most of the E. canis isolates in the three geographical areas from Mexico, including those analyzed in this research, suggesting a common geographic origin among isolates.
Diagnosis and Molecular Pathology of Lymphoblastic Leukemias and Lymphomas in the Era of Genomics and Precision Medicine: Historical Evolution and Current Concepts—Part 2: B-/T-Cell Acute Lymphoblastic Leukemias
Authors: Kansal Rina
Published: July 2023

The diagnosis and treatment of lymphoid neoplasms have undergone a continuously progressive positive change in the last three decades, with accelerated progress in the previous decade due to the advent of genomics in cancer diagnosis. Significantly, there has been an increasing emphasis on integrating molecular genetics with clinical, morphological, immunophenotypic, and cytogenetic evaluation for diagnosis. As we think of moving forward with further advances in the genomics era, it will be first helpful to understand our current state of knowledge and how we achieved it in the challenging and complex field of lymphoid neoplasms, which comprise very heterogeneous neoplastic diseases in children and adults, including clinically acute lymphoblastic leukemias (ALLs) arising from precursor lymphoid cells and clinically indolent and aggressive lymphomas arising from mature lymphoid cells. This work aims to provide an overview of the historical evolution and the current state of knowledge to anyone interested in the field of lymphoid neoplasms, including students, physicians, and researchers. Therefore, I have discussed this complex topic in three review manuscripts, designated Parts 1–3. In Part 1, I explain the basis of the diagnostic classification of lymphoid neoplasms and its evolution up to the current fifth edition of the World Health Organization classification of hematolymphoid neoplasms and the crucial importance of diagnostic tumor classifications in achieving and advancing patient care and precision medicine. In the second and third manuscripts, I discuss current diagnostic considerations for B-ALL and T-ALL (Part 2) and common indolent and aggressive mature leukemias/lymphomas (Part 3), including significant updates in the WHO 2022 classification, newly described entities, and concepts, including genetic predisposition to ALLs and lymphomas, and emphasizing throughout the essential integration of molecular genetics with clinical, morphologic, immunophenotypic, and cytogenetic evaluation, as required for the precise diagnosis of the type of lymphoma/leukemia in any patient.
Synergistic Effects of Environmental Relative Humidity and Initial Water Content of Recycled Concrete Aggregate on the Improvement in Properties via Carbonation Reactions
Authors: Wu Linjian , Zhang Wenxiao , Jiang Han , Ju Xueli , Guan Li , Liu Haicheng , Chen Songgui
Published: July 2023

Moisture is the basis of CO2 transport and carbonation reactions in the internal pores of cement-based materials. Too much or too little moisture influences the effect of the carbonation modification of CO2 on recycled concrete aggregate (RCA). During the carbonation reaction process of RCA, moisture is mainly derived from the environmental relative humidity (RH) and the initial water content (IWC) of the RCA itself. According to the available literature, most of the studies on the effect of moisture on the carbonation modification of RCA considered either RH or IWC. Further investigations of the synergistic effects of RH and IWC on the improvement in the properties of carbonated recycled concrete aggregate (CRCA) are needed. In this study, accelerated carbonation experiments were conducted for RCA samples with different IWCs under different environmental RHs. The results showed that the best moisture conditions for CRCA property improvement were confirmed as RH = 70% for the dry-state IWC and RH = 50% for the saturated-state IWC. When the RCAs were carbonized under the conditions of high RH with low IWC and low RH with high IWC, CO2 had good abilities to permeate and diffuse, with the improvement in CRCA properties achieving excellent levels of performance.
Three Logistic Predictive Models for the Prediction of Mortality and Major Pulmonary Complications after Cardiac Surgery
Authors: Bignami Elena , Guarnieri Marcello , Giambuzzi Ilaria , Trumello Cinzia , Saglietti Francesco , Gianni Stefano , Belluschi Igor , Di Tomasso Nora , Corti Daniele , Alfieri Ottavio , Gemma Marco
Published: July 2023

Background and Objectives: Pulmonary complications are a leading cause of morbidity after cardiac surgery. The aim of this study was to develop models to predict postoperative lung dysfunction and mortality. Materials and Methods: This was a single-center, observational, retrospective study. We retrospectively analyzed the data of 11,285 adult patients who underwent all types of cardiac surgery from 2003 to 2015. We developed logistic predictive models for in-hospital mortality, postoperative pulmonary complications occurring in the intensive care unit, and postoperative non-invasive mechanical ventilation when clinically indicated. Results: In the “preoperative model” predictors for mortality were advanced age (p < 0.001), New York Heart Association (NYHA) class (p < 0.001) and emergent surgery (p = 0.036); predictors for non-invasive mechanical ventilation were advanced age (p < 0.001), low ejection fraction (p = 0.023), higher body mass index (p < 0.001) and preoperative renal failure (p = 0.043); predictors for postoperative pulmonary complications were preoperative chronic obstructive pulmonary disease (p = 0.007), preoperative kidney injury (p < 0.001) and NYHA class (p = 0.033). In the “surgery model” predictors for mortality were intraoperative inotropes (p = 0.003) and intraoperative intra-aortic balloon pump (p < 0.001), which also predicted the incidence of postoperative pulmonary complications. There were no specific variables in the surgery model predicting the use of non-invasive mechanical ventilation. In the “intensive care unit model”, predictors for mortality were postoperative kidney injury (p < 0.001), tracheostomy (p < 0.001), inotropes (p = 0.029) and PaO2/FiO2 ratio at discharge (p = 0.028); predictors for non-invasive mechanical ventilation were kidney injury (p < 0.001), inotropes (p < 0.001), blood transfusions (p < 0.001) and PaO2/FiO2 ratio at the discharge (p < 0.001). Conclusions: In this retrospective study, we identified the preoperative, intraoperative and postoperative characteristics associated with mortality and complications following cardiac surgery.
Edematous Dermal Thickening on Magnetic Resonance Imaging as a Biomarker for Lymphatic Surgical Outcomes
Authors: Kinney JacqueLyn R. , Babapour Sara , Kim Erin , Friedman Rosie , Singhal Dhruv , Lee Bernard T. , Tsai Leo L.
Published: July 2023

Background and Objectives: One of the surgical treatments for breast cancer-related lymphedema (BCRL) is debulking lipectomy. The aim of this study is to investigate whether dermal thickness could be utilized as an objective indicator of post-operative changes following debulking. Materials and Methods: A retrospective review of BCRL patients who underwent debulking lipectomy was conducted. MRI-based dermal thickness was measured by two separate trained readers at 16 regions of the upper extremity. Pre- and post-operative reduction in dermal thickness was compared across the affected and unaffected (control) arms for each patient. The Wilcoxon rank sum test was used to assess for significant change. Univariate linear regression was used to assess the relationship between dermal thickness reduction and changes to LYMPH-Q scores, L-Dex scores, and relative volume change. Results: Seventeen patients were included in our analysis. There was significant reduction in dermal thickness at 5/16 regions in the affected arm. Dermal thickness change was significantly correlated with LYMPH-Q scores, L-Dex scores, and relative volume change in 2/16 limb compartments. There was predominant dermal thickening in the dorsal compartment of the upper arm and in the ventral and ulnar compartments of the forearm. Conclusions: Dermal thickness shows promising utility in tracking post-operative debulking procedures for breast cancer-related lymphedema. Further studies with larger patient populations and a variety of imaging modalities are required to continue to develop a clinically objective and reproducible method of post-surgical lymphedema staging and monitoring.
Permselectivity and Ionic Conductivity Study of Na+ and Br− Ions in Graphene Oxide-Based Membranes for Redox Flow Batteries
Authors: Flack Raphael , Aixalà-Perelló Anna , Pedico Alessandro , Saadi Kobby , Lamberti Andrea , Zitoun David
Published: July 2023

Permselectivity of a membrane is central for the development of electrochemical energy storage devices with two redox couples, such as redox flow batteries (RFBs). In RFBs, Br3−/Br− couple is often used as a catholyte which can cross over to the anolyte, limiting the battery’s lifetime. Naturally, the development of permselective membranes is essential to the success of RFBs since state-of-the-art perfluorosulfonic acid (PFSA) is too costly. This study investigates membranes of graphene oxide (GO), polyvinylpyrrolidone (PVP), and imidazole (Im) as binder and linker, respectively. The GO membranes are compared to a standard PFSA membrane in terms of ionic conductivity (Na+) and permselectivity (exclusion of Br−). The ionic conduction is evaluated from electrochemical impedance spectroscopy and the permselectivity from two-compartment diffusion cells in a four-electrode system. Our findings suggest that the GO membranes reach conductivity and permselectivity comparable with standard PFSA membranes.
Model-Based Decision Support System for Electric Arc Furnace (EAF) Online Monitoring and Control
Authors: Kleimt Bernd , Krieger Waldemar , Mier Vasallo Diana , Arteaga Ayarza Asier , Unamuno Iriondo Inigo
Published: July 2023

In this work, a practical approach for a decision support system for the electric arc furnace (EAF) is presented, with real-time heat state monitoring and control set-point optimization, which has been developed within the EU-funded project REVaMP and applied at the EAF of Sidenor in Basauri, Spain. The system consists of a dynamic process model based on energy and mass balances, including thermodynamic calculations for the most important metallurgical reactions, with particular focus on the modelling of the dephosphorisation reaction, as this is a critical parameter for production of high-quality steel grades along the EAF process route. A statistical scrap characterization tool is used to estimate the scrap properties, which are critical for reliable process performance and accurate online process control. The underlying process models and control functions were validated on the basis of historical production and measurement data of a large number of heats produced at the Sidenor plant. The online implementation of the model facilitates the accurate monitoring of the process behaviour and can be applied for exact process end-point control regarding melt temperature as well as oxygen, carbon and phosphorus content. Embedded within a model predictive control concept, the model can provide useful advice to the operator to adjust the relevant set-points for energy and resource-efficient process control.
Microstructural Characterization of Reactor Pressure Vessel Steels
Authors: Lai Libang , Chekhonin Paul , Akhmadaliev Shavkat , Brandenburg Jann-Erik , Bergner Frank
Published: July 2023

Ion irradiation is a promising tool to emulate neutron-irradiation effects on reactor pressure vessel (RPV) steels, especially in the situation of limited availability of suitable neutron-irradiated material. This approach requires the consideration of ion-neutron transferability issues, which are addressed in the present study by comparing the effect of ions with neutron-irradiation effects reported for the same materials. The first part of the study covers a comprehensive characterization, based on dedicated electron microscopy techniques, of the selected unirradiated RPV materials, namely a base metal and a weld. The results obtained for the grain size, dislocation density, and precipitates are put in context in terms of hardening contributions and sink strength. The second part is focused on the depth-dependent characterization of the dislocation loops formed in ion-irradiated samples. This work is based on scanning transmission electron microscopy applied to cross-sectional samples prepared by the focused ion beam technique. A band-like arrangement of loops is observed in the depth range close to the peak of injected interstitials. Two levels of displacement damage, 0.1 and 1 dpa (displacements per atom), as well as post-irradiation annealed conditions, are included for both RPV materials. Compared with neutron irradiation, ion irradiation creates a similar average size but a higher number density of loops presumably due to the higher dose rate during ion irradiation.