bluuebunny/crossref_metadata_2025 huggingface dataset:
James Ensor na coleção de arte de Murilo Mendes
Authors:   Universidade Federal de Juiz de Fora, Vianna Luisa Pereira
Published: June 2023

Murilo Mendes (1901-1975), o poeta e crítico de arte. Esses dois termos fazem referência direta a sua figura. As pesquisas, em grande parte, estão relacionadas aos escritos do autor. Porém, Mendes também possui um vasto acervo que contém gravuras, pinturas e desenhos. Conjunto que hoje pertence ao Museu de Arte Murilo Mendes, da Universidade Federal de Juiz de Fora. Desta forma, acrescenta-se um terceiro termo: colecionador. São 157 obras que integram seu conjunto. Sendo 76 gravuras, 40 desenhos, 10 pinturas e 31 obras de técnica mista.
Um autorretrato de José Pancetti no Masp: a mitologia do artista
Authors:   Universidade Estadual de Campinas, Rosa Marcos Pedro Magalhães
Published: June 2023

Amítica em torno do pintor José Pancetti é construída por textos de catálogos, biografias e por interpretações amplas do que seria a arte brasileira. Embora diversa, ela guarda no seu núcleo alguns elementos biográficos recorrentemente mobilizados: a profissão marinheiro, a sensibilidade ao mar, o caráter intempestivo e a morte trágica, conclusão da jornada do pintor em busca de seu destino manifesto: a arte moderna. Essa mítica, estruturada de modo textual, guarda relação estreita com a vontade de narrar a institucionalização da arte moderna no país e com a as obras do artista, em especial, os seus autorretratos.
O Femmes Artistes Modernes, o rappel à l’ordre e a obra de Suzanne Valadon
Authors:   Universidade Estadual de Campinas, Siqueira Marina
Published: June 2023

As décadas de 1920 e 1930 foram importantes na história de Suzanne Valadon. Os anos ’20 são o período de maior sucesso econômico em sua carreira, e na década de ’30 ela têm diversas exposições retrospectivas. É também nessa década que Suzanne Valadon é convidada a fazer parte do F.A.M., grupo de mulheres artistas modernas que será o tema deste artigo. Outro fenômeno que coincide com esse período é o retorno à ordem, expressão criada para denominar um momento artístico em que um determinado tipo de arte moderna, distante do academicismo, mas figurativa e mimética, passa a receber expressivo apoio da crítica de arte e aceitação do público. Esse contexto artístico está intimamente ligado à criação do grupo de mulheres artistas modernas aqui citado, pois, como veremos a seguir, o caráter moderno de tal grupo é muito próximo daquele compreendido pelo retorno à ordem. Além disso, as escolhas formais de Suzanne Valadon e o reconhecimento que ela conquista no meio artístico nas últimas décadas de sua vida também guardam alguma relação com o retorno à ordem. Queremos, portanto, analisar nessas próximas páginas qual a natureza da relação entre esse momento histórico, a produção de Suzanne Valadon e o F.A.M.
Arte em tempos de guerra: a Guerra Nigéria-Biafra e o genocídio Igbo na perspectiva dos artistas
Authors:   Universidade Estadual de Campinas, Salles Sandra Mara
Published: June 2023

Ao investigar as narrativas sobre a produção visual do período das independências africanas (ocorridas entre as décadas de 1950 e 1970), percebe-se que ainda são pouco exploradas, no que se refere ao cenário artístico-cultural da Nigéria, as conexões entre a constituição do nacionalismo nigeriano, o lugar dos igbos na identidade nacional e a produção artística no país.
Sociedade e cultura na obra “Mãe Preta” (1912), de Lucílio de Albuquerque
Authors:   Universidade Metodista de Piracicaba, Dume Sarah
Published: June 2023

Através da análise do quadro “Mãe Preta”, de 1912, do pintor de Lucílio de Albuquerque, realizou-se um estudo sobre os indícios presentes na obra que abre uma janela para marcas do período no qual fora efetuada, como a sociedade e cultura que embarcavam os círculos artísticos nos quais Lucílio de Albuquerque estivera inserido até a apresentação de sua obra no Salão de Belas Artes de 1912 da Escola Nacional de Belas Artes (ENBA). Essa análise propõe-se a conjecturar sobre as noções que a obra “Mãe Preta” traz à luz acerca de um dos trabalhos exercidos pelas mulheres negras, livres ou não, durante e após a abolição da escravidão: a função da ama de leite. A partir do espaço artístico em que o artista estava inserido e a sociedade e cultura a qual o artista compartilhava, abriram-se espaços para debates acerca do papel da obra em seu tempo e sobre a ama de leite negra no período dos pós abolição.
Maquetes e jogos educativos como recursos didáticos para o ensino da Vulcanologia no ambiente escolar
Authors: Silva Ivanna Nunes Monterazo , Alves Jully Viviane de Albuquerque , Barreto Carla Joana Santos
Published: June 2023

Os recursos didáticos servem como um meio de facilitação do processo de ensino e aprendizagem e, neste trabalho, será explorada o processo produtivo a produção de maquetes e jogos, escolhidos como recursos que foram construídos com o uso de diversos itens de papelaria, para serem utilizados em oficinas que fazem parte da atuação do projeto de extensão Vulcões e Viagens, vinculado a Universidade Federal de Pernambuco, sendo desenvolvidos para levar o ensino da vulcanologia até a educação básica. O processo construtivo destes recursos possibilitaram aos extensionistas uma aproximação com o conhecimento científico e desenvolvimento da capacidade de simplificação do mesmo para a execução das oficinas. As maquetes e jogos foram apresentadas a mais de dois mil participantes nos estados de Pernambuco e Paraíba e possibilitaram aos estudantes articular os saberes da Geografia escolar às suas temáticas de maior interesse dentro das ciências da Terra: Vulcanismo e Dinossauros.
Ensino não-formal e divulgação das geociências por meio da educação ambiental
Authors: Pinto Ariane Mendes , Silva Luiza Ferreira da , Weber Ana Katiuscia Pastana de Sousa
Published: June 2023

Introdução. Este artigo destaca a importância da Geologia no desenvolvimento do pensamento crítico de crianças em áreas de mineração. Objetivo. O programa de Educação Ambiental Germinar, na cidade de Ouro Branco, Minas Gerais, foi utilizado como estudo de caso para fornecer soluções baseadas em Geociências para os problemas causados pela explotação de recursos naturais e formar indivíduos conscientes da importância do meio ambiente. Metodologia. O estudo consistiu em uma série de atividades pedagógicas, incluindo aulas em ambiente externo e atividades de Realidade Virtual. Resultados e Conclusão. Os resultados mostraram que os alunos apresentam falta de familiaridade com conceitos geológicos, mas a utilização de tecnologias inovadoras e práticas pedagógicas podem contribuir para a conscientização ambiental e do meio em que vivem.
Meandros da redação geocientífica, do esboço ao artigo publicado
Authors: Barbosa Ronaldo , Carneiro Celso Dal Ré
Published: June 2023

Introdução. Para ser reconhecido, um pesquisador deve divulgar adequadamente a ciência que produz. Objetivo. Este artigo aborda as características da escrita geocientífica, uma habilidade que requer esforço contínuo de aprimoramento. Metodologia. Diversas regras e orientações ajudam a desenvolver a habilidade de redação geocientífica. Um bom manuscrito é lido e corrigido muitas vezes pelo autor, e passa por ferramentas de detecção de plágios, erros em citações ou nas fontes originais; em casos graves, um artigo problemático pode ser retratado pelo periódico científico que o publicou. Resultados. Uma comunicação geocientífica pode ser analítica, expositiva ou argumentativa; narrativas são uma categoria à parte. Cinco passos ajudam a transformar ideias vagas em um texto claro e direto: (1) definir o tipo de texto pretendido; (2) definir objetivos, usando perguntas inspiradoras; (3) escrever o primeiro rascunho; (4) reforçar o trabalho com mais fontes e gerar novas versões do texto; (5) organizar as fontes. Conclusão. A introdução, o resumo e o título são redigidos ao final do processo, quando já estão evidentes tanto as limitações quanto a principal contribuição do trabalho para o público-leitor.
Threshold Effect in the Bank Lending Channel of Monetary Policy Transmission and the Role of Bank Portfolio Deterioration: A PSTR Specification in the WAEMU Zone
Authors: PRAO Yao Séraphin , AKA Brou Emmanuel , DJA N’guessan Ferdinand Nicaise
Published: June 2023

The objective of this paper is to analyse the influence of monetary policy on credit supply in the WAEMU zone over the period 1996-2017. The study focuses on the WAEMU countries, except for Guinea-Bissau, due to the unavailability of sufficient data. We apply the Panel Smooth Transition Regression (PSTR) model of Gonzalez et al. (2005). The results reveal the non-linearity of the link between monetary policy and credit supply. There is a threshold of credit risk exposure of 8.726% above which monetary policy loses its effectiveness. Indeed, monetary policy has a positive effect on the supply of credit when the value of the gross bank portfolio deterioration rate is less than or equal to the threshold of 8.726% and an insignificant effect above this threshold. Above this threshold, the link between monetary policy and bank credit supply is distended. In this case, it is the level of economic activity that stimulates the supply of bank credit in this area. These results indicate that the effectiveness of the monetary policy conducted by the Central Bank of West African States (BCEAO), through the bank credit channel, should take into account the level of credit risk attained by banks. Thus, the study recommends that the authorities further strengthen prudential supervision within the WAEMU.
AI-based Compliance Automation in Commercial Bank: How the Silicon Valley Bank Provided a Cautionary Tale for Future Integration
Authors: Hu Bing , Wu Yi
Published: June 2023

Silicon Valley Bank's failure serves as a poignant reminder of the criticality of regulatory compliance and the potential risks that arise from non-compliance. The incident underscores the importance of financial institutions regularly reviewing and adjusting their investment strategies to align with evolving market conditions and risk tolerance levels. In this context, the adoption of advanced technologies such as Financial Enterprise Control Intelligence (FECI) systems becomes imperative. FECI systems are specifically designed to assist financial institutions in effectively managing regulatory compliance and risk management processes. By incorporating advanced technologies like artificial intelligence and data analytics, these systems automate and streamline various aspects of compliance and risk analysis.
Biological insights in non-small cell lung cancer
Authors: Rosell Rafael , Jain Anisha , Codony-Servat Jordi , Jantus-Lewintre Eloisa , Morrison Blake , Ginesta Jordi Barretina , González-Cao María
Published: June 2023

Lung oncogenesis relies on intracellular cysteine to overcome oxidative stress. Several tumor types, including non-small cell lung cancer (NSCLC), upregulate the system xc- cystine/glutamate antiporter (xCT) through overexpression of the cystine transporter SLC7A11, thus sustaining intracellular cysteine levels to support glutathione synthesis. Nuclear factor erythroid 2-related factor 2 (NRF2) serves as a master regulator of oxidative stress resistance by regulating SLC7A11, whereas Kelch-like ECH-associated protein (KEAP1) acts as a cytoplasmic repressor of the oxidative responsive transcription factor NRF2. Mutations in KEAP1/NRF2 and p53 induce SLC7A11 activation in NSCLC. Extracellular cystine is crucial in supplying the intracellular cysteine levels necessary to combat oxidative stress. Disruptions in cystine availability lead to iron-dependent lipid peroxidation, thus resulting in a type of cell death called ferroptosis. Pharmacologic inhibitors of xCT (either SLC7A11 or GPX4) induce ferroptosis of NSCLC cells and other tumor types. When cystine uptake is impaired, the intracellular cysteine pool can be sustained by the transsulfuration pathway, which is catalyzed by cystathionine-B-synthase (CBS) and cystathionine g-lyase (CSE). The involvement of exogenous cysteine/cystine and the transsulfuration pathway in the cysteine pool and downstream metabolites results in compromised CD8+ T cell function and evasion of immunotherapy, diminishing immune response and potentially reducing the effectiveness of immunotherapeutic interventions. Pyroptosis is a previously unrecognized form of regulated cell death. In NSCLCs driven by EGFR, ALK, or KRAS, selective inhibitors induce pyroptotic cell death as well as apoptosis. After targeted therapy, the mitochondrial intrinsic apoptotic pathway is activated, thus leading to the cleavage and activation of caspase-3. Consequently, gasdermin E is activated, thus leading to permeabilization of the cytoplasmic membrane and cell-lytic pyroptosis (indicated by characteristic cell membrane ballooning). Breakthroughs in KRAS G12C allele-specific inhibitors and potential mechanisms of resistance are also discussed herein.
Covid-19 Vaccine Hesitancy and National Security –
Authors: Rokvić Vanja
Published: June 2023

Drawing on the research findings of the survey and a review of the scientific‎ and professional literature, this paper seeks to indicate a correlation between ‎vaccine hesitancy and national security. On the one hand, the paper argues that ‎health is of particular concern to the modern sovereign state and its security,‎ and that the vaccine as a civilizational achievement is one of the most vital‎ mechanisms for safeguarding public health and, by extension, national security.‎ On the other hand, the paper contends that vaccine hesitancy should also‎ be considered a threat to national security. What vaccine hesitancy means and ‎what factors contribute to it is something of a blind spot in Serbia’s public and‎ academic discourse. The survey findings have shown that vaccine hesitancy ‎is influenced by various factors and conclude that Covid-19 vaccine hesitancy ‎in Serbia can be considered a threat to national security.‎
Application of Intelligent Medical Sensing Technology
Authors: Fu Jie , Gao Qiya , Li Shuang
Published: June 2023

With the popularization of intelligent sensing and the improvement of modern medical technology, intelligent medical sensing technology has emerged as the times require. This technology combines basic disciplines such as physics, mathematics, and materials with modern technologies such as semiconductors, integrated circuits, and artificial intelligence, and has become one of the most promising focuses in the medical field. The core of intelligent medical sensor technology is to make existing medical sensors intelligent, portable, and wearable with full consideration of ergonomics and sensor power consumption issues, for conforming to the current trends in cloud medicine, personalized medicine, and health monitoring. With the development of automation and intelligence in measurement and control systems, it is required that sensors have high accuracy, reliability, stability, as well as certain data processing capabilities, self-checking, self-calibration, and self-compensation，while traditional medical sensors cannot meet such requirements. In addition, in order to manufacture high-performance sensors, it is also difficult to improve the material process alone, and it is necessary to combine computer technology with sensor technology to make up for its performance shortcomings. Intelligent medical sensing technology combines medical sensors with microprocessors to produce powerful intelligent medical sensors. On the basis of the original sensor functions, intelligent medical sensors also have functions such as self-compensation, self-calibration, self-diagnosis, numerical processing, two-way communication, information storage, and digital output. This review focuses on the application of intelligent medical sensing technology in biomedical sensing detection from three aspects: physical sensor, chemical sensor, and biosensor.
Biotechnological Potential of Microorganisms for Mosquito Population Control and Reduction of Vector Competence
Authors: Katak Ricardo de Melo , Cintra Amanda Montezano , Burini Bianca Correa , Marinotti Osvaldo , Souza-Neto Jayme A. , Rocha Elerson Matos
Published: June 2023

Mosquitoes transmit pathogens that cause human diseases such as malaria, Dengue fever, Chikungunya, yellow fever, Zika fever, and filariasis. Chemical pesticides are effective instruments for reducing disease transmission and managing mosquito populations. However, these chemicals have drawbacks such as high production costs and negative effects on the environment and non-target organisms. Furthermore, as mosquitoes develop resistance to chemical insecticides, they become less effective. As a result, researchers are investigating novel insecticides. Advances in microbial biotechnology have resulted in a wide range of value-added products, including biopesticides for agricultural and public health purposes. In this review, we highlight the mainly untapped biotechnological potential of microorganisms for vector mosquito control and disease transmission reduction. Also, we underline the importance of more basic research and improved translational research methodologies, encouraging efforts to bridge the gap between academic research on biopesticides and public health interventions.
Alternate Admissibility LMI Criteria for Descriptor Fractional Order Systems with 0 < α < 2
Authors: Di Ying , Zhang Jin-xi , Zhang Xuefeng
Published: June 2023

The paper focuses on the admissibility problem of descriptor fractional-order systems (DFOSs). The alternate admissibility criteria are addressed for DFOSs with order in (0,2) which involve a non-strict linear matrix inequality (LMI) method and a strict LMI method, respectively. The forms of non-strict and strict LMIs are brand-new and distinguished with the existing literature, which fill the gaps of studies for admissibility. These approaches are available to the order in (0,2) without separating the order ranges into (0,1) and [1,2). In addition, a method involved least real decision variables in terms of strict LMIs is derived which is more convenient to process the practical solution. Three numerical examples are given to illustrate the validity of proposed results.
MSTPose: Learning Enriched Visual Information with Multi-Scale Transformers for Human Pose Estimation
Authors: Wu Chengyu , Wei Xin , Li Shaohua , Zhan Ao
Published: June 2023

Human pose estimation is a complex detection task in which the network needs to capture the rich information contained in the images. In this paper, we propose MSTPose (Multi-Scale Transformer for human Pose estimation). Specifically, MSTPose leverages a high-resolution Convolution neural network (CNN) to extract texture information from images. For the feature maps from three different scales produced by the backbone network, each branch performs the coordinate attention operations. The feature maps are then spatially and channel-wise flattened, combined with keypoint tokens generated through random initialization, and fed into a parallel Transformer structure to learn spatial dependencies between features. As the Transformer outputs one-dimensional sequential features, the mainstream two-dimensional heatmap method is abandoned in favor of one-dimensional coordinate vector regression. The experiments show that MSTPose outperforms other CNN-based pose estimation models and demonstrates clear advantages over CNN + Transformer networks of similar types.
Maternal Environment and Priming Agents Effect Germination and Seedling Quality in Pitaya under Salt Stress
Authors: Kenanoğlu Burcu Begüm , Mertoğlu Kerem , Sulusoglu Durul Melekber - , Korkmaz Nazan , çolak Ayşen melda
Published: June 2023

Lack of water and salinity are common problems in many parts of the world. Therefore, some types of cacti can represent as promising crops. Therefore, the ability of cactus species to survive and adapt under natural stress conditions should be evaluated. In this study, it was aimed to evaluate the effect of salt stress on germination and emergence of pitaya seeds obtained from different fruit flesh colors, priming with plant growth regulators, namely salicylic acid (SA), oxalic acid (OA) and mepiquat chloride (MC). The experiment had a completely randomized design with a 2×4×3 factorial scheme corresponding to two pitaya cultivars (white and red fleshed), four NaCl concentrations (0, 2500, 5000 and 10000 ppm), and three PGRs (150 ppm/MC, SA, OC). The following variables were analyzed; germination percentage, mean germination time (MGT), germination stress tolerance ındex (GSTI), shoot length, seedling fresh weight and seedling dry weight ratio. According to the results, it was determined that the growing environment of the seed was important in salt stress resistance, while seeds matured in the environment with red fruit flesh were more tolerant to salt stress than white. Although Pitaya species are relatively salt tolerant, growth (about 30%) was significantly reduced above 2500 ppm and germination (about 45%) above 5000 ppm. MC was found promising as a priming agent in seeds obtained from fruits with white fruit flesh, and OA was found promising as a priming agent in seeds obtained from fruits with red fruit flesh in reducing NaCl-induced stress. Germination percentage stood out as the most important trait determining seed quality and was found to have positive effects on germination stress tolerance index (r: 0.63), seedling length (r: 0.74) and fresh seedling weight (r: 0.56). It is thought that the results obtained may contribute to pitaya cultivation and breeding.
Modelling and Predicting the Growth of Escherichia coli and Staphylococcus aureus in Co-culture with Geotrichum candidum and Lactic Acid Bacteria in Milk
Authors: Ačai Pavel , Koňuchová Martina , Valík Ľubomír
Published: June 2023

The growth of two pairs of co-cultures (Escherichia coli/Geotrichum candidum, and Staphylococcus aureus/Geotrichum candidum) with a starter culture of lactic acid bacteria was studied in milk at temperatures related to artisanal cheesemaking ripening. For an inoculum of approximately 106 CFU/mL, LAB not only induced an early stationary phase of E. coli (two strains BR and PS2) and S. aureus (strains 2064 and 14733) but affected their death phase. G. candidum was found to be the subject of interactions with LAB within a given temperature range only partially. To develop a tertiary model for the growth curves of the populations, a one-step approach was used, combining two types of primary models (Huang and Gimenez and Dalgaard) with secondary square root models for growth rate and lag time. Furthermore, the reparametrized Gompertz-inspired function with the Bigelow secondary model was used to describe the death phase of the E. coli and S. aureus strains. The prediction ability of the growth of the H-GD tertiary model for co-cultures was cross-validated within the strains and data sets in milk and milk medium with 1 % NaCl.
Characteristic Changes in First-Visit Patients with Peripheral Facial Palsy before and during COVID-19 Pandemic: A Single Center Retrospective Study
Authors: Lee Yoonji , Lee Suji , Kim Yong-suk
Published: June 2023

(1) Background: The COVID-19 pandemic has affected healthcare utilization rates on a global scale. This study aimed to analyze whether the COVID-19 pandemic affected the characteristics of first-visit patients with peripheral facial palsy visiting a Korean Medicine hospital and to observe characteristics changes in them. (2) Methods: This study analyzed the electronic medical records of 2,310 first-visit patients with peripheral facial palsy who visited the Facial Palsy Center, Korean Medicine Hospital, Kyung Hee University Medical Center from January 1, 2019 to December 31, 2021 in terms of demographic characteristics, disease phase, residence locations, hospital visit route, and patient care type. (3) Results: There were significant relationships between the presence of the COVID-19 pandemic (i.e., before and during) and the number of patients by disease phase (p=0.043), residence locations (p=0.003), residence locations in Seoul (p=0.003), and patient care types (p=0.003). (4) Conclusions: There were several differences in characteristics of first-visit patients with peripheral facial palsy visiting a Korean Medicine hospital during COVID-19 pandemic in terms of demographic characteristics, disease phase, residence locations, residence locations in Seoul, and patient care types.
Variation in the Drought Tolerance of Tropical Understory Plant Communities across an Extreme Elevation and Precipitation Gradient
Authors: Bravo-Avila Catherine H. , Feeley Kenneth J.
Published: June 2023

Little is known about how differences in water availability within the “super humid” tropics can influence the distribution of understory plant species and the composition of understory plant communities. We investigated variation in the physiological drought tolerances of understory plants and plant communities across a large elevation and precipitation gradient. We established 58 understory plots along a gradient of 400 – 3600 m asl elevation and 1000 – 6000 mm yr-1 rainfall in and around Manu National Park in southeastern Peru. Within the plots, we sampled all understory woody plants and measured three metrics of physiological leaf drought tolerance - turgor loss point (TLP), cuticular conductance (Gmin), and solute leakage (SL) - and assessed how the community-level means of these traits related to mean annual precipitation (MAP) and elevation (in the study gradient temperature decreases linearly and vapor pressure deficit increases monotonically with elevation). We did not find any correlations between the three metrics of leaf drought tolerance, suggesting that they represent independent strategies for coping with low water availability. Despite being widely used metrics of leaf drought tolerance, neither TLP nor Gmin showed any significant relationships with elevation or MAP. In contrast, SL, which has only recently been developed for use in ecological field studies, increased significantly at higher precipitations and at lower elevations (i.e., plants in colder and drier habitats have lower SL, indicating greater drought tolerances). Our results illustrate that differences in water availability may play a strong role in structuring plant communities even in in the wet tropics and highlight the potential for SL assays to be an efficient and effective tool for measuring drought tolerances in the field.
INTEGRATED DEVELOPMENT PLAN – CONNECTING ARCHITECTURAL DESIGN AND SPATIAL PLANNING
Authors:   Instytut Zrównoważonej Przestrzeni w Warszawie, Poland, Wardęski Łukasz
Published: June 2023

The integrated investment plan is to be, after the amendment of the Act on Spatial Planning and Development, a new tool allowing for the development of urbanization opportunities initiated by private and institutional entities. This paper traces the background of design theory in terms of interdisciplinary integration mechanisms within spatial disciplines, and examines how ZPI can use these mechanisms. An initial attempt at a critical assessment and perspectives that emerge in connection with the expected introduction of this legal regulation was made, thus commenting on one of the first ways of legally sanctioned initiation of planning regulations by organized urban or architectural design.
On the Representation of Androgynous Figures in the Renaissance Art
Authors: Redondo Jordi
Published: June 2023

La antigua idea de la androginia –una variante del mito de la metamorfosis– transmitía en la opinión de los pensadores renacentistas las ideas de perfección y plenitud, como medio para superar la oposición de las naturalezas femenina y masculina. El presente trabajo muestra el origen del motivo y su desarrollo según los intereses, creencias e inquietudes de teólogos y pensadores, por un lado, y artistas, por otro.
Palabras clave: Metamorfosis, androginia, perfección, plenitud.
PERAN KIAI DALAM PENGEMBANGAN PENDIDIKAN MODERN DI PONDOK PESANTREN
Authors: Noor Laili Savitri , Nasar Ismail , Novarlia Irena , Anieg Mukhamad , Zulihi Zulihi
Published: June 2023

Tujuan penelitian ini untuk mengetahui Peran Kiai Dalam Pengembangan Pendidikan Modern Di Pondok Pesantren. Metode yang digunakan adalah metode penelitian kualitataif dengan pendekatan studi pustaka. Adapun langkah-langkah dapam penelitian ini yaitu Sumber pustaka yang dimaksud dalam metode penelitian studi pustaka meliputi buku, jurnal ilmiah, makalah, laporan penelitian, dan dokumen-dokumen lain yang relevan dengan topik penelitian yang akan dilakukan. Ada beberapa langkah yang harus dilakukan peneliti dalam penelitian ini, antara lain: a. Menentukan topik penelitian, b. Mencari sumber pustaka yang relevan, c. Menyeleksi sumber pustaka yang relevan dan berkualitas, d. Membaca dan mengevaluasi sumber pustaka yang telah dipilih, e. Menyusun data dan mengekstrak informasi yang relevan, f. Analisis data, g. Menyusun laporan penelitian. Adapaun kesimpulan dari penelitian ini adalah perbedaan antara pesantren Salafiyah dan pesantren Khalafiyah terletak pada pendekatan dan pandangan mereka terhadap ajaran Islam, pendidikan pesantren memiliki banyak keunggulan dan manfaat bagi santri dalam mengembangkan diri. Pesantren memberikan pengalaman belajar yang komprehensif dan mendalam, serta mempersiapkan santri untuk hidup mandiri dan berkontribusi bagi masyarakatpola kepemimpinan Kiai memiliki karakteristik yang dapat membantu mengembangkan pesantren dengan baik. Kepemimpinan transaksional dan transformasional yang diterapkan oleh Kiai dapat membawa pesantren menjadi lembaga pendidikan yang lebih berkualitas. Selain itu, karakteristik kepemimpinan kiai yang efektif dapat menciptakan iklim yang kondusif bagi Santri untuk belajar, para ustadz terlibat dan bertumbuh, serta dukungan dari komunitas dapat membantu pesantren dalam meningkatkan kualitas pendidikan yang diselenggarakan.
Engenharia de Software e Jogos Digitais
Authors: De Castro Leal André Luiz
Published: June 2023

O presente trabalho objetiva possibilitar a alunos e demais envolvidos participar de um processo de aprendizagem de Engenharia de Software (ES) a partir da construção de jogos digitais. Tal associação de domínios de estudo objetiva incentivar os alunos nos estudos da ES, bem como seus subdomínios, tais como, a engenharia de requisitos, linguagem de programação, processo de construção de software, entre outros, em um contexto de interesse de jovens dos primeiros anos de um curso de Sistemas de Informação, os jogos digitais ou games. Para isso é apresentado um programa de extensão já concebido e em execução que serve como estrutura ampla e de longo prazo para diversos projetos relacionados ao contexto de ES aplicada ao desenvolvimento de games, e também iniciativas que objetivem sua socialização, ampla divulgação para aprendizado, captação de recursos, envolvimento de alunos e docentes, parcerias interinstitucional e multilateral, entre outras que possam viabilizar e sustentar o programa. Nossa premissa é que o desenvolvimento de jogos digitais, Serious Games (jogos sérios ou educativos) ou Entertainment (jogos de entretenimento), considerados aqui como software, necessita o envolvimento de atores de perfis distintos em seu processo de construção. Esses diferentes perfis estão envolvidos na aplicação de técnicas e métodos da ES, uma vez que há um nível de alto grau de complexidade da lógica de funcionamento, alta variabilidade de requisitos e distintos objetivos a serem atingidos.
Oficinas de intervenção psicossociais em busca de melhor adesão ao tratamento do diabetes mellitus
Authors: Vilma Muniz de Oliveira Eva , Aparecida Resende Marisângela
Published: June 2023

O Diabetes Mellitus é considerado uma síndrome metabólica que tem acometido um número cada vez mais significativo da população mundial em todas as faixas etárias. Elementos de ordem física, psicológica e social mudam o cotidiano do acometido após o diagnóstico. Nesse sentido, julgou-se importante apresentar os aspectos vivenciados em grupo junto a este público, uma vez que o processo grupal pode ser considerado como uma ferramenta incentivadora para adesão e conservação do tratamento. Objetivou-se relatar a experiência com a prática de Oficinas de Intervenção Psicossocial com acometidos pelo Diabetes Mellitus em uma cidade do interior de MG. Optou-se pelo relato de experiência que advém de resultados obtidos em ações desenvolvidas em um Projeto de Extensão com o uso da prática grupal e visitas domiciliares, envolvendo 20 pessoas com Diabetes. Como resultado, as atividades puderam atuar como grupos de apoio e de educação continuada sendo consideradas como suporte no tratamento, conservação e principalmente na prevenção de complicações advindas do Diabetes. Concluiu-se que se pode criar um espaço de reflexão e debate, fortalecendo-se os vínculos, confiança, troca de experiências, apoio, segurança, isto em sua perspectiva educativa e terapêutica.
Ações interprofissionais de saúde da mulher em um projeto de extensão PET-Saúde
Authors: Louise Gonçalves Caires Tharine , Martins de Souza Juliana , Cassiano Silva Janaina , Camila Coimbra de Mesquita Aura , Brandão Bráz Danichele , Marques Ribeiro Ana Carolina , Barbaresco Rocha Victoria
Published: June 2023

O trabalho em equipe interdisciplinar no campo da saúde pública representa um desafio para o ensino superior e para a prática profissional. Em resposta a essa demanda, criou-se, um programa nacional, no Brasil, o Programa de Educação para o Trabalho em Saúde (PET-Saúde), em que objetiva-se uma articulação efetiva entre ensino, pesquisa e comunidade, haja vista o envolvimento de estudantes de cursos de graduação da saúde com a realidade do SUS, em busca de educação permanente aos trabalhadores do sistema de saúde. Deste modo, este relato de experiência visa descrever as ações do PET-Saúde Interprofissionalidade desenvolvidas em uma cidade do interior de Goiás, período de abril a dezembro de 2019, com enfoque na saúde da mulher a partir do olhar de duas estudantes, duas preceptoras e três docentes. Diante dos resultados, conclui-se que o PET-Saúde proporciona visões diferentes às participantes, mas todas embasadas na sensibilização da importância do trabalho interprofissional.
The optimal second-line therapy for older adults with type 2 diabetes mellitus: protocol for a systematic review and network meta-analysis using individual participant data (IPD)
Authors: Wang Jingya , Nirantharakumar Krishnarajah , Sainsbury Christopher , Moore David J , Sinclair Alan , Thomas G. Neil , Hanif Wasim , Singh Megha , Tan Luyuan , Wang Zhaonan , Simms-Williams Nikita , Yao Mi , Gunathilaka M.Niluka , Singh Pushpa , Toulis Konstantinos , Tsapas Apostolos , Coomar Dyuti , Price Malcolm James
Published: June 2023

Background
Due to increasing life expectancy, almost half of people with type 2 diabetes are aged 65 years or over worldwide. When metformin alone does not control blood sugar, the choice of next medication is not clear from currently available evidence. The existence of frailty and comorbidities in older adults further increases the complexity of medical decision-making. As only a relatively small proportion of trials report results separately for older adults, the relative efficacy and safety of second-line therapies in older adults with type 2 diabetes is unknown and requires further investigation. This individual participant data (IPD) network meta-analysis evaluates the relative efficacy and safety of second-line therapies on their own or in combination in older adults with type 2 diabetes mellitus.
Methods
Published and unpublished trials will be identified building on two previous comprehensive aggregate data network meta-analyses. Searches will be conducted in CENTRAL, MEDLINE, and EMBASE from 1st Jan 2015 onwards, and in clinical trials.gov from inception. Randomized controlled trials with at least 100 estimated older adults (≥ 65 years) receiving at least 24 weeks of intervention that assess the effects of glucose-lowering drugs on mortality, glycemia, vascular and other comorbidities outcomes, and quality of life will be eligible. The screening and data extraction process will be conducted independently by two researchers. The quality of studies will be assessed using the Cochrane risk of bias tool 2. Anonymised IPD of all eligible trials will be requested via clinical trial portals or by contacting the principal investigators or sponsors. Received data will be reanalysed where necessary to standardise outcome metrics. Network meta-analyses will be performed to determine the relative effectiveness of therapies.
Discussion
With the increasing number of older adults with type 2 diabetes worldwide, an IPD network meta-analysis involving data from all eligible trials would provide new insights into the optimal choices of second-line antidiabetic drugs to improve patient management and reduce unnecessary adverse events and the subsequent risk of comorbidities in older adults.
Systematic review registration
PROSPERO CRD42021272686
Extracellular vesicles from neural progenitor cells promote functional recovery after stroke in mice with pharmacological inhibition of neurogenesis
Authors: Campero-Romero Aura , Real Fernando , Santana-Martínez Ricardo , Molina-Villa Tonatiuh , Aranda Cristina , Ríos-Castro Emmanuel , Tovar-y-Romo Luis
Published: June 2023

Neural progenitor cells (NPCs) of the subventricular zone proliferate in response to ischemic stroke in the adult mouse brain. Newly generated cells have been considered to influence recovery following a stroke. However, the mechanism underlying such protection is a matter of active study since it has been thought that proliferating NPCs mediate their protective effects by secreting soluble factors that promote recovery rather than neuronal replacement in the ischemic penumbra. We tested the hypothesis that this mechanism is mediated by the secretion of multimolecular complexes in extracellular vesicles (EVs). We found that the molecular influence of oxygen and glucose-deprived (OGD) NPCs-derived EVs is very limited in improving overt neurological alterations caused by stroke compared to our recently reported astrocyte-derived EVs. However, when we inhibited the ischemia-triggered proliferation of NPCs with the chronic administration of the DNA synthesis inhibitor Ara-C, the effect of NPC-derived exosomes became evident, suggesting that the endogenous protection exerted by the proliferation of NPC is mainly carried out through a mechanism that involves the intercellular communication mediated by EVs. We analyzed the proteomic content of NPC-derived EVs cargo with label-free relative abundance mass spectrometry and identified several molecular mediators of neuronal recovery within these vesicles. Our findings indicate that NPC-derived EVs are protective against the ischemic cascade activated by stroke and, thus, hold significant therapeutic potential.
Factors that influence women’s enrolment and ongoing participation in a partially decentralised randomised controlled dermatology trial: a qualitative interview study with participants in the SAFA (Spironolactone for Adult Female Acne) trial
Authors: Boxall Cherish , Renz Susanne , Eminton Zina , Nuttall Jacqui , Saji Alan , Cluff Charlotte , Wilcox Christopher , Muller Ingrid , Layton Alison , Soulsby Irene , Santer Miriam
Published: June 2023

Background
The use of decentralised clinical trials (which bring trials to patients through remote processes and technology versus central on-site visits) has been thought to be a potential solution to common recruitment and retention barriers. However, there is a lack of evidence to understand the experiences, needs and preferences of the public to inform trial methodologies that appeal to different populations. We report participant experiences of SAFA, a partially decentralised randomised clinical trial, to inform the methodology used in future dermatology trials that aim to appeal to women aged 18 and over.
Methods
Participants of the SAFA (Spironolactone for Adult Female Acne) trial were invited to take part in a qualitative semi-structured interview to explore their experience and perspectives of taking part in the trial. Questions focused on their experience of using decentralised methods to access and enrol in the trial (e.g. social media advertising), in addition to the decentralised trial visit and data collection methods used throughout. Interviews were conducted remotely, recorded, and transcribed. Data were analysed using reflexive Thematic Analysis.
Results
Twelve SAFA participants (all women, age range 22-36) were interviewed. Initially, participants were influenced to enrol by trusted online information, the feeling of validation the trial provided and the convenience and flexibility offered by the decentralised methods and research staff made participants feel valued and enabled them to engage in the trial with minimal interference to existing commitments. SAFA participants were generally accepting of trial demands, such as the text-heavy paperwork and on-site visits for blood collection and highlighted several areas relevant for trial conduct going forwards including where decentralised methods may (and may not) be accepted and how trial accessibility and understanding could be improved.
Conclusions
The study has shown that decentralised methods used by responsive and approachable staff were widely accepted in the SAFA trial. Interviewees found the methods adopted in the SAFA trial helped the trial to fit with their needs and promoted a sense of feeling valued that encouraged ongoing trial engagement. Decentralised methods should be considered favourably when designing a dermatology trial as they can potentially enhance both recruitment and retention.
Trial registration number: ISRCTN number: 12892056
Lidocaine promoted cuproptosis in laryngeal cancer through long noncoding RNA DNMBP-AS1
Authors: Yu Yi , Lv Meihong
Published: June 2023

Background:Lidocaine is a traditional local anesthetic, which has been reported to trigger apoptosis through the mitochondrial pathway, independent of death receptor signaling. Cuproptosis is a copper triggered mitochondrial cell death mode. In this study, we explored the biological effects of lidocaine on laryngeal cancer and studied the relevant mechanisms of cuproptosisMethods:quantitative RT-PCR weas used to measure the expression level of long noncoding RNA (IncRNA) DNMBP-AS1. DNMBP-AS1 siRNA (si-DNMBP-AS1) were transfected into Hep-2 cells to verify the roles of DNMBP-AS1 in cuproptosis. 24 hours treatment with 20 nM elesclomol and 2 µM CuCl2 was performed to promote the occurrence of Cuproptosis. Cell proliferation and apoptosis assays ware utilized to analyze biological effect of lidocaine on Hep-2 cells.Results:DNMBP-AS1 was significantly upregulated during cuproptosis in Hep-2 cells. The si-DNMBP-AS1 significantly increased the cell viability, and suppress the cuproptosis. Lidocaine was cytotoxic to the Hep-2 cells in a dose- and time-dependent manner. Exposure to 10 μM of lidocaine for 24 hours did not reduce the viability, but significantly increased the expression of DNMBP-AS1, and promote the cuproptosis. Anymore, si-DNMBP-AS1 reverse the pro-cuproptosis function of lidocaine.Conclusions:lidocaine was cytotoxic to human laryngeal cancer cells in a time- and dose-dependent manner, promoted the cuproptosis through up-regulating DNMBP-AS1. The results of this study offer initial optimism that lidocaine can be used in an adjuvant or neoadjuvant fashion in laryngeal cancer treatment.
ApoER2-Dab1 disruption as the origin of pTau-related neurodegeneration in sporadic Alzheimer's disease
Authors: Ramsden Christopher E , Zamora Daisy , Horowitz Mark , Jahanipour Jahandar , Keyes Gregory , Li Xiufeng , Murray Helen C , Curtis Maurice A , Faull Richard M , Sedlock Andrea , Maric Dragan
Published: June 2023

BACKGROUND
Sporadic Alzheimer’s disease (sAD) is not a global brain disease. Specific regions, layers and neurons degenerate early while others remain untouched even in advanced disease. The prevailing model used to explain this selective neurodegeneration—prion-like Tau spread—has key limitations and is not easily integrated with other defining sAD features. Instead, we propose that in humans Tau hyperphosphorylation occurs locally via disruption in ApoER2-Dab1 signaling and thus the presence of ApoER2 in neuronal membranes confers vulnerability to degeneration. Further, we propose that disruption of the Reelin/ApoE/ApoJ-ApoER2-Dab1-P85α-LIMK1-Tau-PSD95 (RAAAD-P-LTP) pathway induces deficits in memory and cognition by impeding neuronal lipoprotein internalization and destabilizing actin, microtubules, and synapses. This new model is based in part on our recent finding that ApoER2-Dab1 disruption is evident in entorhinal-hippocampal terminal zones in sAD. Here, we hypothesized that neurons that degenerate in the earliest stages of sAD (1) strongly express ApoER2 and (2) show evidence of ApoER2-Dab1 disruption through co-accumulation of multiple RAAAD-P-LTP components.
METHODS
We applied in situ hybridization and immunohistochemistry to characterize ApoER2 expression and accumulation of RAAAD-P-LTP components in five regions that are prone to early pTau pathology in 64 rapidly autopsied cases spanning the clinicopathological spectrum of sAD.
RESULTS
We found that: (1) selectively vulnerable neuron populations strongly express ApoER2; (2) numerous RAAAD-P-LTP pathway components accumulate in neuritic plaques and abnormal neurons; and (3) RAAAD-P-LTP components were higher in MCI and sAD cases and correlated with histological progression and cognitive deficits. Multiplex-IHC revealed that Dab1, pP85αTyr607, pLIMK1Thr508, pTau and pPSD95Thr19 accumulated together within dystrophic dendrites and soma of ApoER2-expressing neurons in the vicinity of ApoE/ApoJ-enriched extracellular plaques. These observations provide evidence for molecular derangements that can be traced back to ApoER2-Dab1 disruption, in each of the sampled regions, layers, and neuron populations that are prone to early pTau pathology.
CONCLUSION
Findings support the RAAAD-P-LTP hypothesis, a unifying model that implicates dendritic ApoER2-Dab1 disruption as the major driver of both pTau accumulation and neurodegeneration in sAD. This model provides a new conceptual framework to explain why specific neurons degenerate and identifies RAAAD-P-LTP pathway components as potential mechanism-based biomarkers and therapeutic targets for sAD.