bluuebunny/crossref_metadata_2025 huggingface dataset:
Abstract B40: Lineage selective extracellular matrix interactions required for metastatic lung cancer
Authors: Nguyen Don X.
Published: May 2019

Background: Lung cancers are biological heterogeneous malignancies with poor prognosis. The underlying mechanisms of this heterogeneity and their biological consequences for metastasis are poorly understood. We previously examined the molecular relationship between epithelial differentiation states, airway regeneration, lung cancer subtypes, and clinical outcome. By integrating genomics, bioinformatic, and experimental models of lung cancer metastasis, we identified a subset of metastatic lung adenocarcinoma (LUAD) defined by its expression of a novel cell lineage gene expression program (Cheung et al., Cancer Cell 2013).

Results: Here we further define the molecular characteristics of this aggressive LUAD subgroup and find that it is driven by epigenetic silencing of know tumor suppressive non-coding RNAs, including mir-34a-c. This in turn activates genes encoding for specific extracellular matrix (ECM) interacting proteins. These ECM proteins include proteoglycans abundant in the inflammatory stroma of human lung cancers and lung tissue from patients with pulmonary fibrosis. Over-expressions of these proteoglycans and their corresponding cell surface receptors are defining features of recognized LUAD histotypes. In an experimental mouse model, genetic perturbations of these ECM/cell surface interactions inhibits the metastasis re-initiating capacity of LUAD cells to distant organs such as the brain. Significantly, these ECM-tumor cell interactions may also be disrupted using targeted agents currently in clinical trials.

Conclusions: Our data provide a mechanistic link between the effectors of airway homeostasis, pulmonary fibrosis, and metastasis initiation by specific lung cancers. Consequently, we provide rational strategies to re-position current therapies to target the tumor microenvironment of metastatic lung adenocarcinomas.

Citation Format: Don X. Nguyen. Lineage selective extracellular matrix interactions required for metastatic lung cancer. [abstract]. In: Proceedings of the AACR Special Conference on Tumor Metastasis; 2015 Nov 30-Dec 3; Austin, TX. Philadelphia (PA): AACR; Cancer Res 2016;76(7 Suppl):Abstract nr B40.
Abstract B44: Keratin-associated protein 5-5 controls cytoskeletal function and cancer cell vascular invasion
Authors: Berens Eric B. , Sharif Ghada M. , Schmidt Marcel O. , Shuptrine Casey W. , Weiner Louis M. , Glasgow Eric , Riegel Anna T. , Wellstein Anton
Published: May 2019

Cancer cell vascular invasion is a crucial step in the malignant progression towards metastasis. Here we used a genome-wide RNAi screen with E0771 mammary cancer cells to uncover drivers of endothelial monolayer invasion. We identified keratin-associated protein 5-5 (Krtap5-5) as a candidate. Krtap5-5 belongs to large family of cysteine-rich proteins that is implicated in crosslinking keratin intermediate filaments during hair formation. To date, no role of these proteins in cancer has been reported. We found that depletion of Krtap5-5 from cancer cells led to cell blebbing, a loss of keratins 14 and 18 in addition to the upregulation of vimentin intermediate filaments. Krtap5-5 depletion did not impact cell viability but reduced cell motility and extravasation of cancer cells into tissues in a zebrafish model of extravasation. We conclude that Krtap5-5 is a previously unknown regulator of cytoskeletal function in cancer cells that modulates cell motility and vascular invasion.

Citation Format: Eric B. Berens, Ghada M. Sharif, Marcel O. Schmidt, Casey W. Shuptrine, Louis M. Weiner, Eric Glasgow, Anna T. Riegel, Anton Wellstein. Keratin-associated protein 5-5 controls cytoskeletal function and cancer cell vascular invasion. [abstract]. In: Proceedings of the AACR Special Conference on Tumor Metastasis; 2015 Nov 30-Dec 3; Austin, TX. Philadelphia (PA): AACR; Cancer Res 2016;76(7 Suppl):Abstract nr B44.
Abstract B45: An early treatment window to target FAK-dependent collective invasion in Lkb1-mutant lung adenocarcinoma
Authors: Gilbert-Ross Melissa , Konen Jessica , Shupe John , Koo Junghui , Sica Gabriel L. , Ramalingam Suresh S. , Fu Haian , Khuri Fadlo R. , Zhou Wei , Marcus Adam I.
Published: May 2019

LKB1 is the 2rd most commonly mutated tumor suppressor gene in human lung adenocarcinoma, and a biomarker of aggressive disease in stage IV KRAS mutant lung cancer patients. We have previously published that LKB1 acts to limit focal adhesion kinase (FAK) activity in human lung cancer cells to restrict cell adhesion and migration. Based on our prior published data we hypothesize that FAK inhibition will suppress invasion and metastasis in LKB1-mutant tumors in vivo , and represent a viable clinical strategy to target this high-risk patient population. To investigate our hypothesis, we have developed a novel lentiviral-Cre KrasG12D; Lkb1fl/fl Rosa-luciferase genetically engineered mouse model (GEMM) (KLLLenti) that develops 100% adenocarcinomas, and produces a bioluminescent output that correlates with tumor burden, tumor grade, and degree of metastatic colonization of the lymph node. We show that stage IV KLLLenti primary tumors have elevated levels of active FAK in a subset of invasive cells that maintain collective contact via E-Cadherin. Importantly, treatment of KLLLenti mice with a pharmacologic FAK inhibitor potently suppresses invasive progression of primary tumors. Moreover, KLLLenti tumors treated at later stages progress to the same degree as vehicle-treated mice. This result suggests a ‘therapeutic window’ of opportunity, and argues that FAK inhibitors should be part of first-line therapy to treat LKB1-mutant lung cancer patients. We further pursue mechanistic studies to investigate how Lkb1-mutant tumor tissue gains a metastastic advantage in vivo, and using a combination of 3D tumor spheroid assays and multiphoton microscopy present results that Lkb1-mutant tumors use a unique form of hybrid or transitional invasion that on depends on both FAK-based adhesion and collective migration and in doing so, are equipped to more efficiently invade into the collagen-dense microenvironment of the lung. Our studies suggest that when used early, FAK inhibitors may be a viable clinical strategy to prevent metastasis in the LKB1-mutant patient population, and begin to define alternate escape pathways by which this highly invasive cell population may escape first-line therapy.

Citation Format: Melissa Gilbert-Ross, Jessica Konen, John Shupe, Junghui Koo, Gabriel L. Sica, Suresh S. Ramalingam, Haian Fu, Fadlo R. Khuri, Wei Zhou, Adam I. Marcus. An early treatment window to target FAK-dependent collective invasion in Lkb1-mutant lung adenocarcinoma. [abstract]. In: Proceedings of the AACR Special Conference on Tumor Metastasis; 2015 Nov 30-Dec 3; Austin, TX. Philadelphia (PA): AACR; Cancer Res 2016;76(7 Suppl):Abstract nr B45.
Abstract B67: Matriptase is involved in COX-2 signaling-induced prostate cancer cell invasion
Authors: Ko Chun-Jung , Lu Ying-Chieh , Lai Pee-Fang , Hsiao Pei-Wen , Lee Ming-Shyue
Published: May 2019

Chronic inflammation plays an important role in the early development and progression of cancer. Cyclooxygenases-2 (COX-2) is a key rate-limiting enzyme which regulates of inflammation-producing prostaglandins. Several studies have shown that COX-2 is found with overexpression in human cancers (colon, breast, lung, prostate cancers, etc), and implicated in cancer cell invasion. Moreover, high COX-2 expression has been correlated with prostate cancer metastasis. However, the molecular mechanism that COX-2 promotes prostate cancer cell invasion is still unclear. In this study, we established a PC-3 cell invasion progression model (parental and M2I2 PC-3 cells) and found out that several inflammation-associated proteins, COX-2, p-JNK and IL-1β were up-regulated in M2I2 PC-3 cells. Therefore, we purposed that if COX-2 signaling plays a role in prostate cancer cell invasion and the involvement of matriptase in COX-2 signaling-induced cancer cell invasion. The results showed that COX-2 inhibitors (celebrex and sulindac sulfide) could suppress prostate cancer PC3 cell invasion and inhibited matriptase expression and activation. A COX-2 product PGE2 could induce matriptase activation and prostate cancer cell invasion. COX-2 overexpression also could up-regulate matriptase and enhance the cancer cell invasion, while COX-2 silencing antagonized both matriptase activation and cell invasion. Thus, our results indicate that COX-2 signaling can promote prostate cancer cell invasion, at least in part via up-regulating matriptase.

Citation Format: Chun-Jung Ko, Ying-Chieh Lu, Pee-Fang Lai, Pei-Wen Hsiao, Ming-Shyue Lee. Matriptase is involved in COX-2 signaling-induced prostate cancer cell invasion. [abstract]. In: Proceedings of the AACR Special Conference on Tumor Metastasis; 2015 Nov 30-Dec 3; Austin, TX. Philadelphia (PA): AACR; Cancer Res 2016;76(7 Suppl):Abstract nr B67.
Abstract IA12: Microfluidic isolation of circulating tumor cells and microvesicles from cancer patients
Authors: Stott Shannon L.
Published: May 2019

Malignant tumors will aggressively invade surrounding tissue due to rapidly dividing cancer cells that are nourished by an ample blood supply. As these cancer cells are multiplying, they release thousands of tiny particles into the blood stream, referred to as exosomes and microvesicles, which contain genetic information about the tumor. Whole cancer cells are also released from the tumor and these rare circulating tumor cells (CTCs) provide genetic and functional information about the patient's cancer. Through a collaborative effort between bioengineers, biologists, and clinicians, our group at MGH has developed microfluidic devices to isolate both of these rare circulating biomarkers from whole blood. Data from these devices will be presented with a focus on our recent effort to characterize microvesicles and CTCs from patients with glioblastoma. Through the microfluidic isolation of blood based biomarkers from glioblastoma patients, our goal is to obtain complementary data to the current standard of care radiologic measurements to help better guide treatment for this deadly cancer.

Citation Format: Shannon L. Stott. Microfluidic isolation of circulating tumor cells and microvesicles from cancer patients. [abstract]. In: Proceedings of the AACR Special Conference on Tumor Metastasis; 2015 Nov 30-Dec 3; Austin, TX. Philadelphia (PA): AACR; Cancer Res 2016;76(7 Suppl):Abstract nr IA12.
Abstract IA17: Collective epithelial routes to metastatic spread
Authors: Ewald Andrew J.
Published: May 2019

The spread of cancer to distant organs is the major driver of mortality in cancer and, unfortunately, few therapies are effective in patients with extensive metastatic disease. Our hypothesis is that deeper mechanistic insight into the biological basis of metastasis will lead to novel therapeutic concepts. We have focused our laboratory investigations on understanding how epithelial cells acquire the ability to release their connections with their neighbors, migrate through the stroma, and enter the systemic circulation. The prevailing model when we began was the epithelial to mesenchymal transition (EMT), which posited a loss of epithelial features in the cancer cells during metastasis. The EMT model was controversial, in part because metastatic tumors typically retain many epithelial features. However, it remained possible that epithelial features were lost during stages of transit that are difficult to impossible to observe in vivo.

To distinguish these possibilities, we developed novel 3D organoid assays to model normal epithelial growth, to determine the molecular requirements for Twist1 induced dissemination and to identify molecular programs driving the colonization of distant organs. The conclusions drawn across these studies are (1) that there are normal epithelial migratory programs that can be rapidly co-opted through activation of RTK signaling, (2) that the epithelial cell adhesion machinery can facilitate dissemination, and (3) that clusters of breast cancer cells utilize epithelial-specific gene expression (e.g. keratin-14) as they invade, disseminate, and colonize distant organs. These insights lead us to view metastasis as a process that can be accomplished without loss of epithelial character and that these epithelial routes to metastasis may have unique vulnerabilities compared to EMT models. We will discuss the latest progress in these studies and also technical advances in 3D culture that will accelerate metastasis research across organ sites.

Citation Format: Andrew J. Ewald. Collective epithelial routes to metastatic spread. [abstract]. In: Proceedings of the AACR Special Conference on Tumor Metastasis; 2015 Nov 30-Dec 3; Austin, TX. Philadelphia (PA): AACR; Cancer Res 2016;76(7 Suppl):Abstract nr IA17.
The chairman's solution
Authors: Hebert David J.
Published: May 2019

This paper provides a geometric model explaining how a party leader can use the committee assignment process to design optimal committees from the leader's perspective. The purpose of a committee is to reduce the number of people eligible to speak on a particular issue sufficiently so as to allow each participant to fully develop their arguments in a manageable amount of time. In doing so, however, the overwhelming majority of people will be prevented from discussing the particulars of a bill. As a result, party leaders who are able to selectively appoint and promote members to committees are able to use this authority to enforce their own agenda.
The violence trap: a political-economic approach to the problems of development
Authors: Cox Gary W. , North Douglass C. , Weingast Barry R.
Published: May 2019

Why do developing countries fail to adopt the institutions and policies that promote development? Our answer is the violence trap. Natural states prevent violence by providing rents to those with high violence potential. To create rents, however, they must limit entry, which hinders the development of a complex economy whose workings will be seriously disrupted by domestic conflict (raising the cost of fighting) and whose profits will be hard to confiscate (lowering the benefit). Thus, natural states' policy of rent creation hinders the development of the sort of complex economies that would lower the expected payoff to fighting for control of the state. Empirically, we show that economic complexity (as measured by the Hidalgo- Hausmann index) strongly deters coups, even controlling for GDP per capita and level of democracy. Our results remain similar when we instrument economic complexity using the mean complexity of each country's neighbours.
A contradição que não se comunica (The contradiction that cannot be told)
Authors: Godinho Ana
Published: May 2019

Information and knowledge have never been produced so rapidly. Production that finally does not communicate, nor does it act, nor does it have the positive effects that are desired of transference to society. Hyperactivities, fascism, various pathologies, and contradictions, went into such an enterprise. And along with the most daring technological and scientific advances, an unmentionable barbarity is advancing in an overwhelming way. The planetary dangers that result from this production that is not communicated and which we often only become aware of do not cease to threaten us every day and insistently knock on the door. An ambiguous and dangerous global context makes us recover a hypothesis that is more than fifty years old. Proposed by Bateson with a very wide reach the concept of "double bind" helps us to think the relationship between education knowledge and politics.ResumoNunca se produziu tanto e tão aceleradamente informação e conhecimento. Produção que finalmente não se comunica, nem age, nem tem os efeitos positivos que se desejam de transferência para a sociedade. Hiperatividades, fascismos, patologias variadas, contradições e impasses entravam tamanho empreendimento. E a par dos avanços tecnológicos e científicos mais ousados uma barbárie inominável avança de forma avassaladora. Os perigos planetários que resultam desta produção que não se comunica e de que só amiúde nos tornamos conscientes não deixam de nos ameaçar todos os dias e bater com insistência à porta. Um contexto global tão ambíguo e perigoso faz-nos recuperar uma hipótese com mais de cinquenta anos. Proposta por Bateson com um alcance bastante vasto, o conceito de duplo impasse ou “double bind” ajuda-nos a pensar a relação entre educação, conhecimento e política.Keywords: Communication, Contradiction, Double bind, Populism.Palavras-chave: Comunicação, Contradição, Duplo impasse, Populismo.ReferencesBATESON, G. Vers une écologie de l’esprit. (Vol. 1 e 2), Paris: Seuil, 1980.BATESON, G.;  RUESCH, J. Communication et société. Paris: Seuil, 1988.DELEUZE, G.; GUATTARI, F. L’Anti-Œdipe. Paris: Minuit, 1972.DELEUZE, G.; GUATTARI, F. Mille plateaux. Paris: Minuit, 1980.DELEUZE, G.; GUATTARI, F. O que é a Filosofia?. Lisboa: Presença, 1992.DELEUZE, G. Crítica e clínica. Lisboa: Ed. Século XXI, 2000.WATZLAWICK, P.; BEAVIN, J. H.; JACKSON, D. D. Pragmatics of human communication. A study of interactional patterns, pathologies and paradoxes. New York: W.W. Norton & Co, 1967.WATZLAWICK, P.; WEAKLAND, J.; FISCH, R. Changements: paradoxes et psychothérapie. Paris: Seuil,1975.
Assessment of Exit Temperature Pattern Factors in an Annular Gas Turbine Combustor: An Overview
Authors: Muduli S. K. , Mishra R. K. , Mishra P. C.
Published: May 2019

The present paper overviews the works carried out on achieving desired temperature pattern factors at combustor exit in gas turbine engines. These pattern factors are very important from the point of engine performance and life of turbine blades and vanes. They are controlled by a number of geometrical parameters such as liner front-end air passages, primary air holes, atomizer characteristics and air swirl number and dilution zone geometrical configuration. Combustor inlet pressure, Mach number, velocity profile and fuel-air ratio are the major operating parameters that influence the pattern factors. Due to the design uniqueness and importance of pattern factors, it is always a challenge to assess the pattern factors over a wide range of mission points for a gas turbine combustor designed for combat aircraft.
Low-Dielectric-Constant Materials for ULSI Interlayer-Dielectric Applications
Authors: Lee Wei William , Ho Paul S.
Published: May 2019

Continuing improvement of microprocessor performance historically involves a decrease in the device size. This allows greater device speed, an increase in device packing density, and an increase in the number of functions that can reside on a single chip. However higher packing density requires a much larger increase in the number of interconnects. This has led to an increase in the number of wiring levels and a reduction in the wiring pitch (sum of the metal line width and the spacing between the metal lines) to increase the wiring density. The problem with this approach is that—as device dimensions shrink to less than 0.25 μm (transistor gate length)—propagation delay, crosstalk noise, and power dissipation due to resistance-capacitance (RC) coupling become significant due to increased wiring capacitance, especially interline capacitance between the metal lines on the same metal level. The smaller line dimensions increase the resistivity (R) of the metal lines, and the narrower interline spacing increases the capacitance (C) between the lines. Thus although the speed of the device will increase as the feature size decreases, the interconnect delay becomes the major fraction of the total delay and limits improvement in device performance.

To address these problems, new materials for use as metal lines and interlayer dielectrics (ILD) as well as alternative architectures have been proposed to replace the current Al(Cu) and SiO2 interconnect technology.
Nanoporous Silica as an Ultralow-k Dielectric
Authors: Jin Changming , Luttmer J.D. , Smith Douglas M. , Ramos Teresa A.
Published: May 2019

As feature sizes in integrated circuits approach 0.18 μm, problems with interconnect resistance-capacitance (RC) delay, power consumption, and crosstalk become more urgent. Integration of low-dielectric-constant (k) materials will partially mitigate these problems, but each candidate with k significantly lower than that of dense silica (k ∼ 4) suffers disadvantages. Current low-k commercialization emphasizes spin-on glasses (SOGs) and fluorinated SiO2 with k > 3, and a number of polymers are under development with k in the range of 2–3. These suffer from potential problems including thermal stability, mechanical properties, low thermal conductivity, and reliability. For some low-k materials, a protective liner covering the conductor is necessary. Although the material k is often cited, the value of practical concern is the effective k, which may be quite different because of this protective liner. As feature sizes shrink, the presence of the liner becomes more problematic and necessitates even lower k materials.

Another approach employs nanoporous silica with k of ∼1–4. Porous silica has been classified as an aerogel (dried supercritically) or as a xerogel (dried by solvent evaporation). We use the term nanoporous silica since it captures the key material properties that may be independent of how the films are processed. The ultralow dielectric constant results from porosity incorporation. For a porous material, the dielectric constant is a combination of that of air (∼1) and of the solid phase. The variation of k with porosity (volume fraction of pores) appears in Figure 1.
O CONCEITO DE "CENA" NA OBRA DE JACQUES RANCIÈRE: A PRÁTICA DO "MÉTODO DA IGUALDADE"
Authors: Voigt André F.
Published: May 2019

RESUMO O presente artigo pretende sistematizar os principais elementos do conceito de "cena", termo fundamental para a conexão entre teoria e método no pensamento do filósofo francês Jacques Rancière. O "método da igualdade" empregado por Rancière pretende, entre outras coisas, delimitar os diferentes momentos de conflito entre regimes de verdade e atos de tomada da palavra - independentemente de classificações feitas a priori como dados para se investigar um objeto de estudo - por meio do conceito de "literalidade", que demonstra duas lógicas distintas de circulação das palavras: de um lado, uma lógica "policial"; de outro, uma lógica "política". Desta maneira, o conceito de "cena" é um elemento central em uma significativa mudança da relação teoria-metodologia-objeto defendida por boa parte do meio acadêmico, inclusive na área de história, nos dias atuais, uma vez que toma a própria noção de historicidade como descontínua e considera amplamente a racionalidade das palavras em vez da minuciosa articulação dos fatos.
ANÁLISIS DE LOS ASPECTOS FUNDAMENTALES DE LA COMPRENSIÓN JURÍDICA EN CARL SCHMITT Y EXPOSICIÓN DE SUS ALCANCES FILOSÓFICO-GENERALES PARA LA COMPRENSIÓN
Authors: Herrera Hugo Eduardo
Published: May 2019

RESUMEN En este trabajo intento determinar, a partir de textos escogidos de todas las épocas de la producción teórica de Carl Schmitt, de qué manera este autor entiende la comprensión jurídica y de qué manera este modo de comprensión tiene alcances generales para la comprensión práctica. En la medida en que el derecho tematiza las condiciones y los polos de la comprensión, la posición del jurista se distancia tanto de la inclinación hacia el polo ideal, que Schmitt identifica con la racionalidad tecnológica, cuanto de la inclinación hacia el polo real, que Schmitt liga a ciertas formas del romanticismo y el pensamiento teológico.
KANT’S CONSTITUTION OF A MORAL IMAGE OF THE WORLD*
Authors: Klein Joel Thiago
Published: May 2019

ABSTRACT In this paper, I argue that the idea of a universal history is systematically legitimized in Kant’s transcendental system of philosophy by way of the concept of a need [Bedürfnis] for pure practical reason. In this sense, the idea of a universal history is a fundamental part of the moral image of the world that emerges from Kant’s whole philosophy, and it is crucial for understanding both the possibility of the system of pure reason, as well the full development of Kant’s moral philosophy, especially for political philosophy.
THE AGENT'S ROLE IN THE CAUSATION OF ACTION: IS MICHAEL SMITH'S CAUSAL THEORY OF ACTION IN TROUBLE?
Authors: Dalsotto Lucas Mateus
Published: May 2019

ABSTRACT The goal of this paper is to find out if Michael Smith's version of the causal theory of action is able to solve David Velleman's agency par excellence challenge. Smith (2012) has claimed that his theory can deal with the challenge insofar as the exercise of the capacity to be instrumentally rational plays the intermediating role which Velleman (1992a) thinks of the agent as playing in the causation of action. However, I argue Smith misunderstands the challenge at hand, thereby failing to find the agent's proper role in action explanation. Moreover, I claim Velleman's objection puts Smith's account of the causal theory in trouble by showing it cannot reconcile the causal explanation of intentional action with our ordinary conception of agency. If Smith intends to explain what a 'full-blooded' intentional action is, I then believe he needs to incorporate into his theory a more robust account of rational guidance.
From ecosystems to human welfare: the role and conservation of biodiversity
Authors: Zhang Zhenguo , Zhou Jun
Published: May 2019

ABSTRACT: Biodiversity plays a key role in human welfare by providing agricultural, economic, and health benefits. However, following the industrial revolution, the rapid expansion of the human population and subsequent economic activities have caused a dramatic loss in global biodiversity, resulting in significant disturbances to ecosystems and our own living conditions. Accordingly, the conservation of biodiversity has become one of the most important challenges for humanity. The vast numbers of plants, animals, and microorganisms, the enormous genetic diversity of these species and the different ecosystems to which these organisms belong are all part of a biologically diverse planet. A substantial proportion of the world’s biodiversity has been destroyed, this loss is a catastrophe for all living species, including humans. Fortunately, we are working to remedy the destruction of our ecosystems. Herein, we summarized the discovery and development of biodiversity as a field of study and discuss the importance of the genetic and metabolite diversity. We proposed potential solutions to the loss of biodiversity with the aim of facilitating further exploration and identification of biodiversity, contributing for human welfare through the conservation of human habitats.
Criação de uma Simulação para o Desenvolvimento de Competências em um Hospital
Authors: Zucatti Ana Paula Noronha , Silveira Luiza Maria de Oliveira Braga , Abbad Gardênia da Silva , Flores Cecília Dias
Published: May 2019

Resumo: Este artigo descreve a criação, aplicação e análise da eficácia de uma simulação por computador para a identificação e o desenvolvimento de competências de gestão de conflitos e feedback. Foi realizado um estudo exploratório descritivo de abordagem quantitativa em um hospital de Porto Alegre, RS, com 29 enfermeiros, com o objetivo de analisar a eficácia da simulação utilizada em EaD na identificação e desenvolvimento de competências de gestão de conflitos e dar e receber feedback em lideranças enfermeiras de um hospital pediátrico. Foram utilizados três instrumentos: a) questionário de avaliação de liderança, b) simulação sobre gestão de conflitos e feedback, baseado na teoria do Grid Gerencial, e c) avaliação de reação. A comparação entre as respostas do questionário e da simulação demonstram alteração no estilo gerencial dos participantes nas duas dimensões relativas às competências estudadas. A avaliação de reação foi positiva, com satisfação de 89,66% dos usuários. A simulação criada neste estudo se mostrou eficaz para a identificação de competências de gestão de conflitos e dar e receber feedback. Porém, são necessários novos estudos com amostras maiores e métodos de controle para afirmar a eficácia no desenvolvimento de competências.
Construções Identitárias de Psicólogos em NASF: Reflexões para a Prática Profissional
Authors: Vasconcelos Fernanda Gomes , Aléssio Renata Lira dos Santos
Published: May 2019

Resumo: Este artigo teve como objetivo analisar a construção de identidades profissionais de psicólogos no contexto de atuação em Núcleos de Apoio à Saúde da Família (NASF), a partir da dimensão identitária das representações profissionais. Foram realizadas entrevistas com oito psicólogos que atuam em NASF, na cidade do Recife/PE, divididas em duas etapas: a primeira do tipo entrevista narrativa, e a segunda do tipo semiestruturada, orientada por um roteiro, ambas realizadas em um mesmo encontro. As entrevistas foram áudio-gravadas e transcritas na íntegra em formato textual. Os dados foram analisados à luz do método fenomenológico para estudos em Psicologia. Esta análise foi guiada pela organização dos dados a partir de cinco etapas, que resultaram em unidades de significado, dentre as quais foi analisada no artigo a unidade O psicólogo no NASF. Verificou-se que a visão hegemônica da Psicologia atrelada ao contexto da clínica privada produz uma cultura profissional que direciona as demandas para essa categoria e orienta as representações profissionais, bem como a construção de identidades e práticas profissionais. Os profissionais fizeram alusão a recursos da atuação tradicional de cunho individual como um dos meios de resolução do conflito entre a atuação demandada em NASF e suas construções identitárias. À guisa de conclusão, verificou-se que havia para esses profissionais um imperativo de manutenção de uma coerência que sustentasse a identidade profissional, atrelada ao consumo da cultura profissional, mas que se demonstrou, pela via da incoerência, como inconsistente para efetivação de política de atenção básica na saúde.
Estratégias de Atendimento Psicológico a Pacientes Estomizados e seus Familiares
Authors: Silva Natália Michelato , Santos Manoel Antônio dos , Barroso Bruna Caroline Turse , Rosado Sara Rodrigues , Teles André Aparecido da Silva , Sonobe Helena Megumi
Published: May 2019

Resumo: O objetivo deste estudo foi descrever as estratégias de atendimento psicológico utilizadas com pacientes estomizados e seus familiares em uma unidade de internação hospitalar de uma universidade pública do interior paulista no pré-operatório e na preparação para a alta hospitalar. Trata-se de um estudo exploratório-descritivo com abordagem qualitativa, que focaliza um programa de extensão que oferece cuidados, com enfoque interdisciplinar, para essa população. As observações extraídas das intervenções psicológicas foram registradas em diário de campo e os dados obtidos foram submetidos à análise de conteúdo e interpretados à luz de pressupostos teóricos da Psicologia da Saúde. Identificou-se nos relatos que a assistência psicológica contempla as seguintes estratégias: levantamento da história clínica, identificação das necessidades psicológicas do paciente no pré-cirúrgico, reuniões com a equipe para discussão dos casos e elaboração do plano de cuidados terapêuticos, orientação aos familiares, escuta psicológica junto ao leito, orientações ao paciente e avaliação de seu estado psicológico, tendo em vista o preparo para alta hospitalar. O atendimento psicológico tem possibilitado o acolhimento dos pacientes, tendo como foco as necessidades identificadas durante o período de internação hospitalar decorrentes da intervenção cirúrgica e da estomização. O suporte psicológico tem contribuído para fortalecer a autonomia e minimizar o sofrimento associado à cirurgia e suas consequências, frente às limitações impostas pelo adoecimento crônico intestinal, além de possibilitar o atendimento articulado com a equipe cirúrgica e de enfermagem, assegurando assistência continuada ao paciente com foco no desenvolvimento de competências de autocuidado.
Estresse e Características Resilientes em Alunos com Deficiência e TFE na UFPA
Authors: Pereira Rosamaria Reo , Silva Simone Souza da Costa , Faciola Rosana Assef , Pontes Fernando Augusto Ramos , Ramos Maély Ferreira Holanda , Ramos Edson Marcos Leal Soares
Published: May 2019

Resumo: Poucos são os pesquisadores que tratam da presença do estresse e da resiliência em alunos com deficiência e com Transtornos Funcionais Específicos no ensino superior, o que sinaliza a necessidade dessas duas temáticas serem mais estudadas e melhor compreendidas no ambiente universitário. A presente pesquisa visou descrever as características sociodemográficas e acadêmicas de 50 estudantes universitários participantes da pesquisa e correlacioná-las com os níveis de estresse e de resiliência. Os instrumentos utilizados foram um questionário semiestruturado e duas escalas: Escala de Estresse Percebido e Escala de Resiliência. Os resultados foram analisados por meio da estatística descritiva e da técnica estatística exploratória. Os resultados apontaram que alunos com níveis elevados de estresse têm níveis moderados e baixos de resiliência. A partir desse resultado, concluiu-se a necessidade de desenvolvimento de programas que visem à manutenção de estratégias eficazes de enfrentamento diante de situações adversas dentro do contexto acadêmico. Espera-se que este estudo possa contribuir com a construção de políticas institucionais que favoreça a inclusão de fato de estudantes com deficiência e com TFE na Universidade Federal do Pará e em outras instituições de ensino superior.
Effect of adding fungicide to mixtures of triazoles and strobilurins in the control of downy mildew and Asian soybean rust
Authors: Zuntini Bruno , Alvarez Rita de Cassia Félix , Theodoro Gustavo de Faria , Zuffo Alan Mario
Published: May 2019

ABSTRACT Fungicides used to control the Asian soybean rust are composed almost entirely of mixtures involving the systemic (triazoles) and meso-systemic (strobilurins) modes of action. However, to control the soybean downy mildew, only protective fungicides are available. The present study aimed to evaluate the effectiveness of fungicides with different modes of action in the control of downy mildew and Asian soybean rust. A field experiment was carried out in a randomized block design, with seven treatments [negative control; difenoconazole at V7 + (azoxystrobin + cyproconazole) at R2 and R5.1; (tebuconazole + carbendazim) at V7 + (azoxystrobin + tebuconazole) at R2 and R5.1; carbendazim and mancozeb at V7 + (azoxystrobin + tebuconazole) at R2 and R5.1; (tebuconazole + carbendazim) at V7 + mancozeb in V7 + (azoxystrobin + tebuconazole) at R2 and R5.1; (tebuconazole + carbendazim) at V7 + (azoxystrobin + tebuconazole) at R2 and R5.1 + mancozeb at R2 and R5.1; (tebuconazole + carbendazim) at V7 + azoxystrobin + tebuconazole at R2 and R5.1 + mancozeb at R2 and R5.1 + carbendazim at R5.1] and four replicates. The following variables were evaluated: disease severity based on diagrammatic scales, phytotoxicity, product effectiveness, defoliation, number of pods per plant, number of seeds per pod, 1,000-seed weight and yield. The treatments with mancozeb addition showed to be more efficient in reducing the severity of mildew and Asian soybean rust and defoliation, providing increased seed yields for the crop. For the soybean downy mildew, the treatments with addition of mancozeb to benzimidazole, strobilurins and triazoles were more efficient in reducing the severity and for the control.
Evaluation of stability of balance recovery from unpredictable perturbations through the compensatory arm and leg movements (CALM) scale v1
Authors: Torres Betelli Marina , Sayuri Takazono Patrícia , Ribeiro de Souza Caroline , Ávila de Oliveira Julia , Boari Coelho Daniel , Augusto Teixeira Luis
Published: May 2019

The scale for evaluation of compensatory arm and leg movements (CALM) was developed to evaluate balance stability recovery after unpredictable displacements of the support base in the mediolateral direction. The mediolateral perturbations are applied in three modes: rotation, translation or combined rotation-translation, to either side, in three platform peak velocities: 20º-20 cm/s (low), 30º-30cm/s (intermediate) or 0º-40 cm/s (high), keeping peak acceleration of 500o/s2(cm/s2) and displacement amplitude of 7o (cm) constant across perturbations. The factors perturbation mode (3), direction (2) and velocity (3) of platform displacement are combined to generate 18 distinct stance perturbations. To create the context of unpredictability, perturbations are pseudorandomly sequenced. To become aware of the stance perturbations, participants watch a video demonstrating a person responding to the different platform perturbations included in the protocol. After video watching, subjects are warmed up for 5 min. with global movements. Initial feet positions are marked on the support base with adhesive tapes (5-cm width). Other adhesive tape marks are fixed 15 cm away from the outer border of the feet to either side, in parallel to the feet orientation. The initial participant’s posture on the platform is keeping the Romberg’s stance, with the feet oriented forward, touching each other, maintaining both arms relaxed hanging beside the trunk, and palms of the hands lightly touching the upper legs. Participants wear a safety harness supported by two ropes tied at the shoulders height with the other end attached overhead. The participant’s aim across perturbations is to recover balance after support base displacements trying to maintain the initial body posture. Participants’ responses are filmed from behind using a commercial digital camera (Sony), for off-line analysis based on the CALM scale.
Formulasi Breakfast Meal Flakes dari Tepung Suweg dan Stabilized Rice Bran Menggunakan Metode Respon Permukaan
Authors: Nuriana Adha , Aini Nur , Karseno Karseno
Published: May 2019

Penelitian bertujuan untuk mengetahui jumlah tepung suweg dan stabilized rice bran (SRB) yang harus ditambahkan dalam formula breakfast meal flakes (BMF) yang optimal serta mengetahui karakter fisik, kimia, dan organoleptik BMF yang dihasilkan. Penelitian menggunakan metode respon permukaan dengan model Central Composit Design. Faktor yang diteliti yaitu proporsi tepung suweg dan SRB. Pembuatan BMF dilakukan dengan cara pencampuran tepung suweg (proporsi 70-85%) dan SRB (proporsi 15-30%) dengan bahan lainnya yaitu tapioka 10%, susu skim 15%, garam 1,5 %, margarin 5%, baking powder 3 %, vanili 1% (seluruh persentase terhadap berat tepung suweg dan SRB) dan air 100 ml, hingga membentuk adonan, kemudian dilakukan steam blanching, dicetak dan dipanggang. Penelitian ini berhasil untuk menentukan formula optimum untuk pembuatan BMF yaitu sebesar 22,5% untuk SRB dan 77,5% untuk tepung suweg. Produk BMF dari formula terbaik ini mempunyai hardness sebesar 29,44 N, dan serat pangan, antioksidan, protein, kadar lemak, kadar air, kadar abu dan karbohidrat masing-masing sebesar 15,93, 75,10, 11,7, 9,51, 2,4, 2,16, dan 64,21 %. Warna produk akhir adalah coklat keabuan dengan tekstur yang renyah serta aroma yang netral. Rasa pada produk akhir adalah dinilai tidak pahit dengan nilai kesukaan adalah disukai panelis. Kesimpulannya, formula optimal BMF dari tepung suweg dan SRB berhasil ditentukan dengan menggunakan metode respon permukaan.Formulation of Breakfast Meal Flakes Based on Suweg Flours and Stabilized Rice Bran using Response Surface MethodologyAbstractThe purpose of this research was to study the amount of suweg flour and stabilized rice bran (SRB) which must be added in the optimal breakfast meal flakes (BMF) formula and to study the physical, chemical, and organoleptic characteristics of BMF was produced. The study used Response Surface Methodology with the Central Composite Design model examined the proportion of suweg flour and SRB. Making BMF is done by mixing suweg flour (70-85%) and SB flour (15-30%) with other ingredients namely 10% tapioca starch, 15% skim milk, 1.5% salt, 5% margarine, 3% baking powder, 1% vanilla (all percentages of the weight of suweg flour and SRB), and 100 ml of water, to form a mixture, then steam blanching, molded and baked. The best formula for BMF is the proportion of 22.5 % of SRB and 77.5% of flour suweg. Breakfast meal flakes have a hardness value of 29.44 N, dietary fiber 15.93%,  antioxidant of 75.97%,  protein content of 11.7%, fat of 9.51%, moisture of 2.4%, ash content of 2.16%,  the carbohydrate content of 64.21%, color of 2.3 (grayish brown), texture of 3.3 (crispy), flavor 2.5 (neutral), taste of 2.9 (not bitter), and preference 2.9 (likes). As conclusion, surface response method successfully determined the optimal BMF formula from flour suweg and SRB.
Compensation Algorithms Based On The P-q And Cpc Theories For Switching Compensators In Micro-grids
Authors: Monteiro L. F. C. , Afonso J. L. , Pinto J. G. , Watanabe E. H. , Aredes M. , Akagi H.
Published: May 2019

The main objective of this paper is to compare the applicability and performance of a switching compensa-tor when it is controlled by algorithms derived from the pq–Theory and from the Current’s Physical Components Power Theory (CPC-Theory) considering a micro-grid application. Compensation characteristics derived from each one of these set of power definitions are highlighted, and simulation results of test cases are shown. Special attention is put on the oscillating instantaneous real power, as it may produce torque oscillations or frequency variations in weak systems (micro-grids) generators. The oscillating instantaneous real power, as defined in the pq-Theory, gives the amount of energy oscillating between the source and the load, and its compensation using a switching compensator must have an energy storage element to exchange it with the load. The energy storage element can be easily calculated with the pq-Theory.
Critical Evaluation Of Fbd, Pq And Cpt Current Decompositions For Four-wire Circuits
Authors: Marafão Fernando P. , Paredes Helmo K. M. , Silva Luiz C. P. da
Published: May 2019

This paper investigates the major similarities and discrepancies of three important current decompositions proposed for the interpretation of unbalanced and/or non linear three-phase four-wire circuits. The considered approaches were the so-called FBD Theory, the pq-Theory and the CPT. Although the methods are based on different concepts, the results obtained under ideal conditions (sinusoidal and balanced signals) are very similar. The main differences appear in the presence of unbalanced and non linear load conditions. It will be demonstrated and discussed how the choice of the voltage referential and the return conductor impedance can influence in the resulting current components, as well as, the way of interpreting a power circuit with return conductor. Under linear unbalanced conditions, both FBD and pq-Theory suggest that the some current components contain a third-order harmonic. Besides, neither pq-Theory nor FBD method are able to provide accurate information for reactive current under unbalanced and distorted conditions, what seems to be done by means of the CPT.
Association of single nucleotide polymorphisms in the insulin and growth hormone gene with growth traits of Mia Chicken
Authors: Thinh Nguyen Hoang , Tuan Hoang Anh , Vinh Nguyen Thi , Doan Bui Huu , Phuong Giang Nguyen Thi , Frédéric Farnir , Nassim Moula , Linh Nguyen Viet , Dang Pham Kim
Published: May 2019

This study was conducted in Mia chicken breed to evaluate the association between four single nucleotide polymorphisms (SNPs), in insulin (INS) and growth hormone (GH) genes, with growth traits. Three genotypes for the SNP A3971G of INS gene and the SNP G662A and C423T of GH gene were present in the population while only two genotypes were found in the Mia chicken breed for SNP T3737C of INS gene (TT and TC). The SNP T3737C INS gene and G662A GH gene had significant association with growth traits (P less than 0.05). A significant association of T3737C INS gene with body weight (BW) was observed at 10 to 12 weeks of age and average daily gain (ADG) at 6-8 weeks of age. The SNP G662A of the GH gene was significantly associated (P less than 0.05) with BW of Mia chicken at ages from 7 to 14 weeks and with ADG (4-6; 6-8; 8-10; 10-12 and 2-16 weeks). Chicken with the GG genotype had greater BW and ADG compared to the other genotypes. The results demonstrated that this SNP G662A GH gene may be used as a candidate marker gene for genetic improvement of growth traits in Mia chicken breed.
The Reliability and Validity of the Arabic Version of the Composite Abuse Scale
Authors: Alhalal Eman , Ford-Gilboe Marilyn , Wong Carol , Albuhairan Fadia
Published: May 2019

Research that examines intimate partner violence (IPV) in the Arab world has been hampered by a lack of comprehensive valid and culturally appropriate measures. The purpose of this study was to test the reliability and validity of the Arabic version of the Composite Abuse Scale (CAS) in a sample of 299 Saudi women recruited from primary healthcare centers. Confirmatory factor analysis (CFA) did not support the original four-factor structure of CAS. Exploratory factor analysis revealed that the item pool reliably distinguished four different types of abuse (physical abuse, verbal abuse, sexual abuse, and control). Two items were dropped from the scale leaving a 27-item scale. The final four-factor model with 27 items was supported through further CFA, including analyses supporting the fit of the four-factor model on a higher level, second-order concept (IPV). Total and subscales CAS scores demonstrate excellent to good reliability and evidence of concurrent validity based on correlations with established measures of depression (Center for Epidemiologic Studies-Depression [CESD]) and posttraumatic stress disorder (PTSD) (PTSD Checklist-Civilian Version [PCL-C]).
The Bank For International Settlements: An Evolutionary Institution
Authors: Hughes Michael P. , Palke Chris
Published: May 2019

Established in 1930 in Basel, Switzerland, to expedite and supervise the payment of reparations by Germany to the victors of World War I, the Bank for International Settlements (BIS) quickly evolved into a banking establishment for various national central banks to negotiate and work out mutually-beneficial monetary policies and financial arrangements outside of the usual political and national channels. During World War II the BIS stayed open as a neutral central bank for central banks and provided significant back-channel communications between the Allied and Axis powers that could not have occurred any other way. As an example, discussions for the reconstruction of post-WWII Germany were underway between German and Allied representatives to the BIS at least two years prior to Germany’s surrender in May 1945. The post-WWII BIS then went on to become a global central bank for the world’s national central banks. In spite of the BIS holding so much effective financial power on an international scale and, hence, affecting nearly everyone in the world, few have ever heard of the BIS. This includes many economists and financial-economists. Why? Although technically not a secret organization, the BIS has always maintained an intentionally low profile. The BIS has never advertised its existence. It operates through many other organizations it has either directly created or where it holds major influence. This paper discusses the BIS, its history, and its impact and influence on world events. Questions concerning the role the BIS should possibly play in world events and central banking are raised for discussion near the end of this paper.

This paper is focused primarily towards both upper-level undergraduate and graduate finance and economics courses, particularly in the areas of money, banking and financial institutions, financial markets, and monetary policy. However, other courses, to include those outside of the financial-economic arena, can find great use for this subject matter as well. Such outside arenas could include political science and history courses.