bluuebunny/crossref_metadata_2025 huggingface dataset:
THE ROLE OF THE INTERNATIONALIZATION OF THE HIGHER EDUCATION SYSTEM OF UKRAINE ON THE WAY TO THE EUROPEAN UNION
Authors:   SSI «Institute of Educational Analytics», Chymbay Liudmyla , Popkova Larysa ,   SSI «Institute of Educational Analytics», Khaniuk Tetiana ,   SSI «Institute of Educational Analytics»
Published: December 2022

The article is devoted to the training of specialists with higher education in the context of the integration of Ukraine into the European educational space. Nowadays it is necessary to implement European principles, approaches and practices into the Ukrainian education policy through fundamental reforms in the field of education. The analysis of scientific research has shown that the academic mobility of all participants in the educational process contributes to the internationalization and adaptation of the national education system of Ukraine to European criteria. Special attention was paid to the current legislation of Ukraine, which regulates legal, organizational and financial relations in the process of implementing academic mobility in the training of competitive specialists with higher education. The article defines the advantages of international academic mobility in the educational process, contains a list of countries with the largest contingent of Ukrainian students and a list of the most popular universities of Ukraine, chosen by foreign citizens for obtaining higher education. Based on the data of the Erasmus+ National Office, the results of Ukraine's participation in the exchange projects of the Erasmus+ program, and joint master's programs Erasmus Mundus and Jean Monnet were analyzed. The paper outlines exceptional measures taken within the framework of the approved European Union Directives to support Ukrainian educators and facilitate their integration into educational projects. Foreign organizations and programs that support the international academic mobility of participants in the educational process are given as an example of cooperation between well-known Ukrainian HEIs with scientific institutions and universities of other countries. Attention is paid to the modern approaches available to Ukrainian students to obtain quality higher education, namely their participation in virtual international academic mobility and double degree programs. This issue is now relevant and could be the subject of further research. In general, the participation of Ukrainian students and researchers in international academic mobility projects has been identified by the authors as an important factor in achieving the goals of the Bologna process and the training of highly qualified and competitive specialists at the European level.
THE NUS REFORM AS A COMPONENT OF THE UKRAINIAN EDUCATION INTEGRATION INTO THE EUROPEAN EDUCATIONAL SPACE
Authors:   SSI «Institute of Educational Analytics», Denisyuk Oksana , Dron Tetiana ,   SSI «Institute of Educational Analytics», Tytarenko Nataliia ,   SSI «Institute of Educational Analytics», Tkachenko Valentyna ,   SSI «Institute of Educational Analytics»
Published: December 2022

The paper considers the basic principles of the European educational space. The article is aimed to determine the main ways of integrating the domestic educational system into the European educational space through the prism of the New Ukrainian School (NUS) reform. It was pointed out the European Community does not require that the specificities of member countries' education systems be levelled. On the contrary, its priorities include effective cooperation, exchange of experience while preserving the national characteristics of each educational space, promotion of continuous training of EU citizens, carrying out measures to increase the mobility of applicants for education, developing joint educational programmes and exchange of information, etc. In the current conditions of crisis and war in Ukraine, the European community is open to Ukrainian schoolchildren, teachers and scientists. Hubs and special programs for supporting the Ukrainian educational and scientific sphere are being created. The NUS reform in Ukraine is a key element for integration into the European educational space because many provisions of this reform have common features with the principles of the European Community educational system. In particular, it is the formation of competencies necessary for successful self-realization in society, pedagogy based on the partnership between student, teacher and parents, trained and motivated teacher, having the freedom of creativity and developing professional, orientation to the student needs in the educational process, child-centeredness, inclusiveness of educational environment, etc. However, for effective European integration, Ukraine’s educational system must take a number of steps that will ensure the transformation of the domestic educational space into European. In particular, to create a road map for the entry of the Ukrainian education system into the European educational space, to expand the autonomy of educational institutions, to ensure appropriate training of scientific and pedagogical personnel, to reform the system of financing education in Ukraine, to introduce modern educational technologies, to improve the quality of teacher training, ensure international cooperation between educational institutions, etc.
THE IMPACT OF EUROPEAN INTEGRATION PROCESSES ON THE PROSPECTS OF REFORMING THE FINANCIAL SYSTEM OF GENERAL SECONDARY EDUCATION IN UKRAINE
Authors:   SSI «Institute of Educational Analytics», Gapon Valentyna , Barabash Olena ,   SSI «Institute of Educational Analytics», Chytaieva Kateryna ,   SSI «Institute of Educational Analytics»
Published: December 2022

The article considers theoretical and practical aspects of financing general secondary education in Ukraine and the European Union member states, in particular in Finland, Estonia and Germany. Studies of Ukrainian and foreign researchers on the problems of the decentralization of secondary education management, expanding the autonomy of education authorities at the local level, and establishing the rights and responsibilities of the institutions both in educational processes and in financial support were analyzed. The article justifies the importance of implementation of the reform of decentralization in Ukraine, as a result of which the rights of local self-government bodies in making managerial decisions, in particular in the system of financial resources and control, have been expanded. Analytical indicators of the efficiency of the use of funds of educational subsidies allocated for payment of salaries of teaching staff in 2021 are provided, and the relationship between the cost of education per student and the number of classes in the general secondary education institutions is established. The example of the rural territorial communities helped to prove that the larger the number of classes in the general secondary schools, the lower the cost of education per student. The most common factors of mismanagement and misuse of public and local budgets were identified, in particular the lack of sound forecasting and planning; the misuse of financial resources; unreasonable management decisions; long-term maintenance of the balances of educational subvention funds without the use of the accounts of budget fund managers and the current accounts of educational institutions, etc. The planned amounts of the educational subvention and the subvention for the provision of support for persons with special educational needs for 2022, as well as the remaining unused funds under these subventions, were analyzed in detail. The volumes of the sequestration of subventions, which took place as a result of the military aggression of the russian federation against Ukraine are given. Further research will include the systematization and development of financial reporting forms for a comprehensive analysis of the use of financial resources at all levels of school education management.
Evolution Of Halal Research: A Bibliometric For 1996 – 2020
Authors: Has-Yun Hashim Yumi Zuhanis , Ahmad Anis Najiha , Samsudin Nurhusna , Abd Lateef Miratul Hayah , Majlan Nurul Shahirah
Published: December 2022

The purpose of this review was to examine the evolution of halal research across various sectors in the last two decades, identify research gaps, and explore future research directions. This study employed the Scopus database to identify articles with the term “halal” within the publication year of 1996 to 2020. Bibliometric and network analyses were performed on 1770 articles using VOSviewer software 1.6.13. Citation metrics were generated using Publish and Perish v7 software. Halal research themes encompassed different disciplines. Halal authentication was found to be the largest cluster among a total of 10 clusters.  Emerging research areas include halal cosmetics, halal food supply chains, and halal tourism. Islamic finance and banking were found to be relevant in the halal ecosystem. Untapped areas include modest fashion, halal media and recreation, halal curriculum, halal science, and interrelationship between halal practice and Islamic faith. Responding to the COVID-19 pandemic, technologies surrounding digitisation and the Internet of Things are foreseen to be re-emerging hot areas. This study covers comprehensive halal research topics, including banking and financial aspects. A summary of recent bibliometric studies on halal is included in the discussion. The study also accentuates the keyword analysis that has enabled the identification of mature, emerging, and untapped clusters of halal research.  The evolution of halal research was mapped to the Islamic economic sectors of the Global Islamic Economy Report to provide cogent arguments on the halal research landscape.
Pembelajaran Jarimatika di Yayasan Aulia Rahmah Hasanah, Balikpapan
Authors: Rizalmi Sigit Rahmat , Karim Abdul Alimul , Hertadi Christopher Davito Prabandewa , Anwar Putri Gesan Prabawa
Published: December 2022

Pengabdian kepada masyarakat merupakan bagian dari salah satu Tri Dharma Perguruan Tinggi. Yayasan Aulia Rahmah Hasanah merupakan panti asuhan yang menampung anak yatim piatu dan juga anak yang kurang beruntung. Keterbatasan SDM dan sarana prasarana membuat kemampuan anak asuh yang mengalami kemunduran dibandingkan dengan anak-anak seumurannya. Pada saat ini terdapat beberapa metode pembelajaran yang dapat digunakan para pengajar atau pendidik sebagai transfer of knowledge bagi anak – anak. Metode pengajaran yang dipakai adalah Jarimatika. Metode pembelajaran ini cocok bagi anak dengan sedikit keterbatasan pengetahuan atau kemampuan dalam membaca (Tunagrahita) sehingga memudahkan mereka dalam menyerap informasi yang akan disampaikan oleh tenaga pengajar atau pendidik. Metode ini dilakukan dengan tahapan tes pendahulu, pembelajaran jarimatika, dan diakhiri dengan tes akhir dan dilakukan selama 3 bulan dan dikemas ke dalam 7 pertemuan.  Hasil dari pengabdian masyarakat ini menunjukan terdapat peningkatan waktu penyelesaian soal matematika sederhana dengan menggunakan metode jarimatika.
Pelatihan Inspeksi Pengelasan dengan Metode Penetran Test Sesuai Standart AWS D1.1 di SMK Negeri Robatal Kabupaten Sampang
Authors: Risdianto Anauta Lungiding Angga , Syarifuddin Arief , Iswidodo Windra , Prasetyo Taufan
Published: December 2022

Madura luas wilayah 1233,33  terdiri atas 4 Kabupaten, salah satunya Kabupaten Sampang. Sampang memiliki (IPM) berada pada nilai 61,9 %. Kondisi tersebut dipengaruhi oleh minimnya minat menlanjutkan ke jenjang lebih tinggi. Melihat kondisi maka, dilakukan pengabdian berupa pelatihan dengan tujuan meningkatkan pengetahuan pada bidang inspeksi hasil las yang dilaksanakan di SMK Negeri Robatal Jurusan Teknik Kendaraan Ringan  yang dihadiri oleh perwakilan sebanyak 30 peserta, besar harapan bahwa siswa SMK dapat diserap secara maksimal oleh industri. Metode yang dilakukan berupa presentasi, praktek menggunakan pengujian penetran tes, dan evaluasi.  Hasil post test rata rata nilai 70 dan presentasi pemahaman 90 % dari data tersebut menunjukkan pengabdian ini mudah dipahami. Hasil evaluasi dari kegiatan ini peserta dapat memahami tentang penetran tes, dapat mengidentifikasi cacat permukaan dan dapat memahami standar yang digunakan dalam proses inspeksi. Setelah dilaksanakan pelatiahan ini peserta dapat menerapkan ilmu berupa pengelasan yang baik terutama di bidang konstruksi kendaraan ringan.
Analisis Makna dan Nilai Nilai Moral Pada Puisi Anak Usia Sekolah Dasar dengan Tema Lingkungan
Authors: Kinasih Arum , Exa Hasna Nabila , Amalia Siva Anisa , Yulisetiyani Septi
Published: December 2022

The author chose the topic of analyzing meaning and moral values ​​so that elementary school age students can easily absorb the meaning and understand the moral values ​​contained in children's poetry so that they can be implemented in everyday life. The author took samples of 6 poems on the poindua.net website by Yunita. The method used by the author is the literary study method with data analysis techniques in the form of interactive analysis. The results of the analysis carried out by the author show that children's poetry has several implied meanings so it is difficult to understand and contains moral values ​​in it. One of the results of the poem that we analyzed was entitled "Rainbow" with the moral value contained, namely being grateful for all the blessings that God has given us.
HUBUNGAN KONFORMITAS DENGAN FANATISME SUPORTER KLUB SEPAK BOLA ARSENAL DI KOTA MADIUN
Authors:   Widya Mandala Surabaya Catholic Univercity Indonesia, Yunus Alfian , Wicaksono David Ary ,   Widya Mandala Surabaya Catholic Univercity Indonesia
Published: December 2022

Penelitian ini bertujuan untuk mengetahui hubungan konformitas dengan fanatisme suporter klub sepak bola Arsenal di Kota Madiun. Jumlah subjek dalam penelitian ini adalah 45 orang yang tergabung dalam grup media sosial WhatsApp Arsenal Indonesia Suporter Madiun. Penelitian ini menggunakan metode kuantitatif, dengan menggunakan skala konformitas dan skala fanatisme sebagai alat pengumpul data. Data yang diperoleh dianalisis menggunakan korelasi product moment dari Karl Pearson. Hasil pengujian koefisien korelasi yang diperoleh adalah 0,826 dengan nilai signifikansi p=0,000 (p<0,05). Dengan demikian hasil penelitian ini menunjukan hipotesis diterima dan ada hubungan yang signifikan antara konformitas dengan fanatisme suporter klub sepak bola Arsenal di Kota Madiun.
HUBUNGAN ANTARA RELIGIOSITAS DENGAN HARDINESS PADA MAHASISWA KATOLIK TINGKAT AKHIR DI SURABAYA
Authors:   Widya Mandala Surabaya Catholic University Indonesia, Cahyasari Emanuela Adika , Susilo Dicky ,   Widya Mandala Surabaya Catholic University Indonesia, Tedjawidjaja Detricia ,   Widya Mandala Surabaya Catholic University Indonesia
Published: December 2022

Mahasiswa memiliki tanggung jawab untuk menyelesaikan studinya di perguruan tinggi. Tidak sedikit mahasiswa yang berada dalam kondisi tertekan, sehingga dibutuhkan hardiness untuk dapat bertahan dalam situasi penuh tekanan. Hardiness adalah suatu karakteristik yang terdiri dari komitmen, kontrol, dan tantangan yang mempunyai fungsi dan strategi untuk dapat beradaptasi dan bertahan dalam menghadapi keadaan stres. Salah satu faktor yang mempengaruhi hardiness adalah strategi koping dengan implementasinya yaitu religiositas. Adanya hubungan spiritual dengan orang lain dan mengakui campur tangan Tuhan, akan membantu dalam mengendalikan dan mengarahkan diri dalam mengatasi permasalahan. Tujuan dari penelitian ini untuk mengetahui ada tidaknya hubungan antara religiositas dengan hardiness pada mahasiswa Katolik tingkat akhir di Surabaya. Subjek dalam penelitian ini sebanyak 91 mahasiswa. Teknik pengambilan sampel yang digunakan dalam penelitian ini yaitu accidental sampling. Skala yang digunakan dalam penelitian ini yaitu skala Hardiness dan skala Religiositas. Hasil analisis data menggunakan korelasi Pearson Product Moment menghasilkan r=0,555 (p<0,05) yang berarti bahwa terdapat hubungan positif antara religiositas dan hardiness pada mahasiswa Katolik tingkat akhir di Surabaya. Semakin tinggi religiositas pada diri seseorang maka semakin tinggi pula hardiness seseorang dan begitu pula sebaliknya.
CAREER DECISION MAKING SELF-EFFICACY (CDMSE) DENGAN CAREER INDECISION PADA MAHASISWA TINGKAT AKHIR
Authors:   Faculty of Psychology Widya Mandala Catholic University of Surabaya Indonesia, Repi Andhika Alexander , Kurniawati Angela ,   Faculty of Psychology Widya Mandala Catholic University of Surabaya Indonesia
Published: December 2022

Kehidupan mahasiswa akhir tidak hanya dikelilingi oleh banyaknya beban tugas dan pengerjaan skripsi atau tugas akhir saja, namun juga dihadapkan pada pilihan untuk memilih masa depan. Jika mahasiswa akhir tersebut, tidak dapat menentukan bidang karir yang akan ditekuni di masa depan maka akan timbul perasaan bimbang dan ragu pada pilihan karirnya. Hal ini disebut dengan career indecision. Terdapat beberapa faktor yang mempengaruhi kebimbangan karir pada mahasiswa akhir, salah satunya adalah efikasi diri pada bidang karir yang disebut juga Career Decision Making Self-Efficacy (CDMSE). Dengan metode penelitian kuantitatif, peneliti menyebarkan kuisioner melalui google form dan didapatkan total 79 responden mahasiswa akhir yang tersebar di beberapa fakultas UKWMS. Tujuan penelitian ini adalah untuk mengetahui ada atau tidak hubungan antara Career Indecision dan juga Career Decision Making Self-Efficacy (CDMSE). Berdasarkan hasil penelitian, nilai sig sebesar 0,000 (p < 0,05) yang berarti ada hubungan yang negatif antara Career Decision Making Self-Efficacy dengan Career Indecision pada mahasiswa akhir Universitas Katolik Widya Mandala Surabaya. Artinya, semakin tinggi tingkat kebimbangan mahasiswa mengenai karirnya, maka semakin rendah keyakinan pada kemampuannya di bidang karir yang akan ditekuni. Begitu pula sebaliknya, semakin rendah tingkat kebimbangan mahasiswa akan karirnya, maka mahasiswa semakin yakin dengan kemampuannya di bidang karir yang ditekuni. Hasil ini didukung dengan sumbangan efektif yang diberikan Career Decision Making Self-Efficacy (CDMSE) terhadap Career Indecision (CI) sebesar 66,6%, yang artinya CDMSE memiliki peran yang kuat untuk menentukan bimbang tidaknya mahasiswa tingkat akhir di Universitas Katolik Widya Mandala Surabaya.
WORK ENGAGEMENT DENGAN PERCEIVED ORGANIZATIONAL SUPPORT PADA KARYAWAN YANG MELAKUKAN WORK FROM HOME
Authors:   Fakultas Psikologi, Universitas Katolik Widya Mandala Surabaya Indonesia, Apsari Florentina Yuni , Wijaya Vincentius Michael ,   Fakultas Psikologi, Universitas Katolik Widya Mandala Surabaya Indonesia
Published: December 2022

The COVID-19 pandemic has caused the work system that was originally in the office to now work from home or what we usually know as work from home (WFH). Work from home causes employee not to get full support from the company, such as the absence of work support facilities and having to provide work needs while work at home. These things make employee more lazy at work, feel their work is heavy, etc. decreased enthusiasm for wok is one aspect of work engagement. According to Schaufeli & Bakker (2004) work engagement is a condition of thinking about work where a person has positive thoughts and feels happy about work that is formed through vigor, dedication, and absorption. The factor that affect work engagement are perceived organizational support. Researchers use quantitative research method, researchers use google form as a medium for data collection. The number of subjects obtained by the researchers were 84 respondents (WFH employees). The results of this study show sig. of 0.000 (p <0.05) means that there is a relationship between work engagement and perceived organizational support for employees who do WFH. This study is supported by a correlation value of 0.391 and an effective contribution of 31.9% so that it can be said that the two variables studied have a positive relationship, which means that when individuals have high perceived organizational support, the individual will also have high work engagement. On the other hand, when an individual has low perceived organizational support, the individual will have low work engagement.
Jurnalisme Imersif dan Partisipasi Publik dalam Industri Media
Authors:   Universitas Indonesia, Indonesia, Paramitha Clara Ariski
Published: December 2022

This article aims to introduce the concept of immersive journalism as a new genre in digital journalism. Hierarchy of influence is used to understand the condition of immersive journalism in the media industry. This article describes the condition of digital journalism in Indonesia and the concept of immersive journalism using the literature review method. The results of the analysis show that the production, distribution, and consumption processes of news are influenced by internal and external media organizations. The public participation opportunity that has been created in digital journalism has the potential to sustain in immersive journalism. The audience can actively participate and have control over narrative construction. A series of challenges in the development of immersive journalism that have been identified include business potential, adaptation of supporting tools, narrative creation, and vulnerability to manipulation. The dilemmatic problems faced by media industry players will be even more complex if they apply immersive journalism: redefining with the audience the limits of participation, narrative framing, objectivity, and sensitive content.
Pengungkapan Diri Mahasiswa pada Media Sosial Twitter (Studi Etnografi Virtual Akun Autobase @Collegemenfess)
Authors:   Universitas Riau Indonesia, Avdijan Aliyyah Aura , Rumyeni Rumyeni ,   Universitas Riau Indonesia
Published: December 2022

The phenomenon of anonymous self-disclosure on social media is currently increasingly found, one of which is on social media Twitter. The @collegemenfess Twitter account is an autobase account that is widely used as a medium for student self-disclosure, especially about college issues and campus life.The purpose of this study was to determine the form of areas and motives of self-disclosure and cyber culture formed on the autobase @collegemenfess account. The study used descriptive qualitative methods. The Data in this study were obtained through interviews with 5 informants and observations on communication activities in cyberspace Twitter account @collegemenfess. The results showed that there were two forms of johari Window area that occurred in the self-disclosure in the @collegemenfess account, which occurred in the open area and the blind area. Furthermore, it is known that there are five motives for users to do self-disclosure, the @collegemenfess account is anonymous, users are afraid to tell stories with others directly, to share information and experiences, to overcome problems and get a better understanding, and motivation and actualization. The study also found five levels of cyber culture formed, namely the first level of media space, where the @collegemenfess account uses Twitter as a medium. Second, the level of media documents, where the media documents in this account are the access, interaction, activities and responses from users. Third, the media object level, where the @collegemenfess account is used as a place to discuss such as exchanging stories and expressing yourself. Finally, the experience level, which is the reason the account owner created this account to provide a communication platform for students and user communication culture using an anonymous identity.
Persepsi Publik, Kapasitas Personal dan Kepemimpinan Presiden Joko Widodo dalam Mengatasi Pandemi Covid-19
Authors:   Universitas Gadjah Mada Indonesia, Ahmad Nyarwi
Published: December 2022

This article is directed to examine how did Indonesian people perceived Joko Widodo’s personal competence and leadership resiliency during the covid-19 pandemic era and the degree to which did political preference of these people on political party carry out effects on such perceptions. Focusing on these issues, this article adopts concepts of presidential leadership, personal competence, resilient leadership and political preference, collects the survei data derived from 1200 respondents using a multistage random sampling and extracts the survei data using descriptive and cross tabulation statistical analyses. The finding indicates that the Indonesian people’ perception of Joko Widodo’s personal competence and leadership resiliency to handle covid-19 pandemic-related problems varied. Most of them perceived that President Joko Widodo had personal competence and leadership resiliency to manage covid-19 pandemic. Polical preference of these people on political party are likely to determine these perceptions however. These evidences confirms that not merely a perception bias among these people regarding Joko Widodo’s personal competence and leadership resiliency to manage covid-19 pandemic-related problems keep evolving, but also political preference of these people on political party have been taking place as a determinant factor. This hints that a perception bias remained taking shape as influential factor that determines the development of Indonesian (electoral) politics.
Melihat Dunia dengan Simulakra (Mengkaji Baudrillard dan Masyarakat Konsumsi)
Authors:   Universitas Mulawarman Indonesia, Purwanti Silviana
Published: December 2022

This paper is a literature review that elaborates Baudrillard's thoughts on Simulacra in Consumption Society which can be used as a study in understanding the phenomenon of consumption society today and in the future. Basically, according to Baudrillard, consumption in its process can be analyzed in two basic perspectives, namely: as a process of meaning and communication based on rules (code), where consumption practices appear and receive their meaning. Here, consumption is a language-appropriate system of exchange. Second, as a process of social classification and differentiation, this time defines objects/signs not only as significant differences in one code, but as values (rules) that are appropriate in a hierarchy. Consumption can be the subject of strategic power-determining discourse here, especially in the distribution of values that follow rules (except in relation to other social signals: knowledge, power, culture, etc.). In other words, Baudrillard's theory is able to connect the dynamics of consumption society with self-actualization and social needs.
Geometric similarity measures and their applications
Authors:   , Vermeulen Jordi Luca
Published: December 2022

Similarity measures are used in many applications, from comparing and searching for images to procedural content generation. They let us rank objects in order of similarity to a query, and they let us guide many search-based algorithms by telling us how good a chess move is, or how much our generated content resembles a given example. In this thesis, we specifically explore geometric similarity measures, which are used to quantify the resemblance between two geometric objects. We expand on the theoretical understanding of similarity measures, showing how the earth mover's distance can be approximated for a variety of simple geometric objects. We also find new applications for well-studied similarity measures by showing how the Hausdorff distance can be used to interpolate between two shapes, creating a morph. Additionally, we take a detour to study a new model of indeterminacy in graphs.
microRNAS in Therapy Resistance of Breast Cancer
Authors: Jung Janine , Wagner Vinona , Körner Cindy
Published: December 2022

Breast cancer is one of the deadliest cancer types worldwide and consists of several subtypes differing in their molecular characteristics; each subtype requires various effective treatment strategies. Development of resistance to radiation or therapeutic agents is one of the main factors leading to the death of about 450,000 breast cancer patients each year. Since microRNAs (miRNAs) have been shown to be key players in health and disease, it is not surprising that they influence the development of resistance to treatment and thereby affect the fate of patients suffering from different types of cancer. miRNAs typically modulate the expression of hundreds of targets, forming a complex regulatory layer which we have only begun to understand. This review summarises miRNAs that confer resistance to different treatment options or sensitise breast cancer cells to a particular treatment. Moreover, this review addresses the high clinical value of miRNAs as biomarkers that allow prediction or monitoring therapy response. The focus of the review is to illustrate how much we know already but also to emphasise that a vast part of the miRNome and its implications for breast cancer therapy resistance remains in the dark and requires further investigation.
Understanding the Microenvironment of Melanoma Cells for the Development of Target Drug Delivery Systems
Authors: Naves Lucas B. , Almeida Luis , Ramakrishna Seeram
Published: December 2022

Melanoma is the most aggressive and deadly form of skin cancer. The high rate of patient death is related to advanced melanoma metastasis, which usually occurs several months to years after the primary melanoma diagnosis. At an early stage, the melanoma tumour can be removed, therefore promoting a survival rate up to 99%. In this manuscript, we elucidate the tumour microenvironment factor, which is crucial for melanoma growth, proliferation, and metastasis. Melanoma is more resistant to traditional therapies, such as chemotherapy and radiotherapy; indeed, tumour-associated macrophages are often related to the worst prognosis. A better understanding of the melanoma microenvironment, including melanoma-associated fibroblasts and hypoxia-inducible factors, will enable researchers to develop drug-delivery systems with higher anticancer activity than current melanoma therapies available on the market. This review also covers macrophage targeting melanoma, such as macrophage colony-stimulating factor receptor inhibitors, C-C chemokine ligand 2 inhibitors, and vaccines combining αFAP-PE38 and melanoma associated antigens via lentiviral vectors. We also report a study using statins, which demonstrated long circulating liposome-encapsulate simvastatin reduced tumour-associated macrophage-mediated oxidative stress and production of the hypoxia-inducible factor 1α in tumours. In melanoma, xenografts may be treated with antiangiogenic agents targeting different angiogenic pathways, such as properdistatin, which selectively removes small diameter vessels and reduces the blood supply time. Sunitinib also plays a role in reducing the density of small and large diameter vessels, although it does not change the blood supply time. Considering all these factors holistically suggests that a better understanding of the melanoma microenvironment is crucial for the development of a novel and effective therapeutic approach.
The acquisition of demonstratives in a complex noun class system
Authors: Sagna Serge , Vihman Virve‑Anneli , Vihman Marilyn , Brown Dunstan
Published: December 2022

We present an exploratory study of 2- to 3-year-old children’s acquisition of the demonstrative system of Eegimaa (ISO 369–3 bqj), an endangered language belonging to the Jóola cluster of the Atlantic family of the Niger-Congo phylum, spoken by about 13,000 speakers in southwestern Senegal. Eegimaa demonstratives express distance from speaker (proximal, medial and distal) and the agreement categories of number and gender, as well as having four morphological types that create an additional dimension of complexity for children to learn. These demonstrative types are each associated with a range of syntactic functions with partial overlaps.

From nearly seven hours of recordings, including children at three age points (2;0, 2;6 and 3;0), we extracted 218 demonstrative tokens from the children’s speech, matched with 205 tokens from a sub-sample of caregiver speech. The youngest children can be described as restricting their use of demonstratives to a small set of learned items, with evidence of generalisation and productivity arising over the course of development, alongside an increase in frequency and development in distribution patterns of the various demonstrative forms to more target-like usage in the 3;0 sample. At age three we observe more variation by syntactic function. As has been found in other languages, children acquiring Eegimaa seem to make use of the diverse forms of demonstratives early, but they do not yet make use of the full range of forms even at age three, when they are beginning to produce more systematic forms of the demonstratives across syntactic contexts and with a variety of genders.
Agreeing inflected quantifiers, intensifiers and anaphors as derived personal pronouns: Evidence from Tatar
Authors: Lyutikova Ekaterina
Published: December 2022

In this paper, I analyse the intricate agreement pattern attested with inflected quantifiers, intensifiers and anaphors in Tatar, which can trigger not only a default 3rd person agreement, but also the marked person agreement reflecting the features of their restrictor or binder. I claim that in these constructions, inflected quantifiers, intensifiers and anaphors bear the features the agreement reveals, and propose a mechanism allowing them to acquire the features of their restrictor or binder. I build on the idea that agreeing inflected quantifiers, intensifiers and anaphors contain a minimal pronoun equipped with a set of unvalued interpretable features, and that this feature set gets valued via agreement.
Life and Language Beyond Earth: Could we communicate with exobeings?
Authors: Hickey Raymond
Published: December 2022

My talk will address four basic questions about life and language beyond Earth with a specific focus on attempted answers to the fourth. Is there any life beyond Earth? Is there intelligent life beyond Earth? Is this life technologically advanced enough to communicate with us? Does such life have a communication system which we would recognise as language?
A review of swine heat production: 2003 to 2020
Authors: Ramirez Brett C. , Hoff Steven J. , Hayes Morgan D. , Brown-Brandl Tami , Harmon Jay D. , Rohrer Gary A.
Published: December 2022

Swine heat production (HP) data are an essential element of numerous aspects affecting swine production sustainability, such as, housing environmental control design, energetics and thermoregulation modeling, as well as understanding of feed energy partitioning. Accurate HP values that reflect the continuous advances in growth, nutrition, health, and reproduction are needed to update outdated models and data; hence, this review of swine HP values is a critical contribution. This review updates the last previous review conducted in 2004, by reviewing literature from growing and breeding pigs from 2003 to 2020. In total, 33 references were identified that provided relevant HP data and from these references, 192 records were identified for pigs ranging in weight from 12.5 to 283 kg and exposed to temperatures between 12.0°C and 35.5°C. For growing pigs at thermoneutral conditions, a 4.7% average increase in HP was observed compared to HP data summarized from 1988 to 2004. Only five records were identified for gestating sows and the 43 records for lactating sows plus litter. This sow data shows high variability and inconsistent trends with temperature, most likely attributed to variation in experimental protocols, management, and limited reported information. There is still a lack of data on growing pigs greater than 105 kg, gilts and gestating sows housed in different systems (stall, pen, mixed, etc.), and latent HP values that reflect different housing systems. Further, there is a need to standardize reporting of HP values (with an example provided) across different disciplines to drive documentation of increased swine production efficiency, environmental control design, and energetics modeling.
Application of yeast in plant-derived aroma formation from cigar filler leaves
Authors: Yao Lan , Huang Chenyi , Ding Jingyi , Zhang Tongtong , Yu Jun , Yang Chunlei , Chen Xiong
Published: December 2022

Introduction: There are various degrees of defects of cigar filler leaves after air drying.

Methods: In order to improve the quality and plant-derived aroma content of cigar filler leaves, nine aroma-producing yeasts were applied in artificially solid-state fermentation of cigar filler leaves in this study. The differences with various yeasts application were compared by chemical composition and GC-MS analysis.

Results and discussion: The results showed that 120 volatile components were identified and quantified in cigar filler leaves after fermentation, including aldehydes (25 types), alcohols (24 types), ketones (20 types), esters (11 types), hydrocarbons (12 types), acids (4 types) and other substances (23 types). Based on the analysis of odor activity value (OAV), the OVA of fruity and floral aroma components were higher. It was found that floral aroma are the representative aroma types of cigar filler leaves treated with Clavispora lusitaniae, Cyberlindera fabianii, Saccharomycosis fibuligera and Zygosaccharomyces bailii R6. After being inoculated with Hanseniaspora uvarum J1, Hanseniaspora uvarum J4 and Pichia pastoris P3, the OAV of fruity aroma in cigar filler leaves was the highest, followed by tobacco aroma and woody aroma. The correlation between volatile components of cigar filler leaves with different yeasts was revealed after PCA analysis. It was concluded that the quality of cigar filler leaves was improved, and cigar filler leaves fermented with different yeasts showed different flavor.
Human parvovirus B19 infection in hospitalized patients suspected of infection with pathogenic microorganism
Authors: Guo Junshuang , Wang Yating , Zhang Mian , Zheng Hongxiang , Zang Qiuling , Huang Peipei , Wen Lijun , Song Dandan , Yang Fan , Dong Ruirui , Miao Wang
Published: December 2022

Background

Human parvovirus B19 (HPV B19) is a single-stranded DNA virus. The detection rate of HPV B19 in the blood of healthy blood donors using PCR technology was reported to be 6.323/100000. However, that among hospitalized patients suspected of being infected with a pathogenic microorganism is unknown.

Methods

A retrospective analysis was conducted on 2,182 high-throughput NGS results for 1,484 inpatients admitted to the First Affiliated Hospital of Zhengzhou University from January 2020 to October 2021 who were suspected of being infected with a pathogenic microorganism, as well as on clinical data of some HPV B19-positive patients.

Results

Human parvovirus B19 was detected in 39 samples from 33 patients. The positivity rate was 2.22% among patients and 1.78% among samples. HPV B19 was detected in 20 cerebrospinal fluid samples, 13 blood samples, 3 alveolar lavage fluid samples, 2 tissue samples, and 1 throat swab. Based on clinical symptoms and NGS results, 16 patients were diagnosed with HPV B19 infection. The number of HPV B19 sequences in these patients was greater than 6, and the patients showed common symptoms such as fever (14 cases), anemia (11 cases), and severe nervous system symptoms such as meningoencephalitis (9 cases) and Guillain–Barré syndrome with peripheral motor and sensory nerve axon damage (4 cases). All 16 patients had experienced events likely to lead to decreased immunity (11 had a history of trauma/surgery/major disease, 4 had a history of precursor infection, and 3 had used immunosuppressants) and 7 had a history of blood transfusion during hospitalization. After treatment with antiviral drugs (12 cases) and intravenous human immunoglobulin (3 cases), of the 16 patients, 14 patients improved.

Conclusion

The HPV B19 infection rate in hospitalized patients suspected of microbial infection was 2.22%. Most patients with HPV B19 infection had a history of low immunity and blood transfusion. HPV B19 could be detected in various bodily fluids and tissues (especially cerebrospinal fluid) using NGS. Patients with severe HPV B19 infection may have nervous system damage such as Guillain–Barré syndrome and meningoencephalitis. Early diagnosis using NGS and treatment with antiviral drugs and immunoglobulin can improve prognosis.
Neuroscience is ready for neuroethics engagement
Authors: Das Jayatri , Forlini Cynthia , Porcello Darrell M. , Rommelfanger Karen S. , Salles Arleen ,   Global Neuroethics Summit Delegates
Published: December 2022

Neuroscience research has been expanding, providing new insights into brain and nervous system function and potentially transformative technological applications. In recent years, there has been a flurry of prominent international scientific academies and intergovernmental organizations calling for engagement with different publics on social, ethical, and regulatory issues related to neuroscience and neurotechnology advances. Neuroscientific activities and outputs are value-laden; they reflect the cultural, ethical, and political values that are prioritized in different societies at a given time and impact a variety of publics beyond the laboratory. The focus on engagement in neuroscience recognizes the breadth and significance of current neuroscience research whilst acknowledging the need for a neuroethical approach that explores the epistemic and moral values influencing the neuroscientific agenda. The field of neuroethics is characterized by its focus on the social, legal, and philosophical implications of neuroscience including its impact on cultural assumptions about the cognitive experience, identity, consciousness, and decision-making. Here, we outline a proposal for neuroethics engagement that reflects an enhanced and evolving understanding of public engagement with neuroethical issues to create opportunities to share ideation, decision-making, and collaboration in neuroscience endeavors for the benefit of society. We demonstrate the synergies between public engagement and neuroethics scholarship and activities that can guide neuroethics engagement.
Echocardiography protocol: A tool for infrequently used parameters in mice
Authors: Todd Emily Ann , Williams Monique , Kamiar Ali , Rasmussen Monica Anne , Shehadeh Lina A.
Published: December 2022

Echocardiography is frequently used to evaluate cardiac function in rodent models of cardiovascular disease. Whereas methods to acquire the commonly used echocardiography parameters are well-described in published protocols or manuals, many important parameters are ill-defined and often open to subjective interpretation. Such lack of uniformity has engendered conflicting interpretations of the same parameters in published literature. In particular, parameters such as mitral regurgitation, mitral stenosis, pulmonary regurgitation, and aortic regurgitation that are required to define more esoteric etiologies in rarer mouse models often remain equivocal. The aim of this methods paper is to provide a practical guide to the acquisition and interpretation of infrequently used echocardiography parameters and set a framework for comprehensive analyses of right ventricle (RV), pulmonary artery (PA) pulmonary valve (PV), left atrium (LA), mitral valve (MV), and aortic valve (AoV) structure and function.
Cardiac sequelae after COVID-19: Results of a 1-year follow-up study with echocardiography and biomarkers
Authors: Matejova Gabriela , Radvan Martin , Bartecku Elis , Kamenik Martin , Koc Lumir , Horinkova Jana , Sykorova Lubica , Stepanova Radka , Kala Petr
Published: December 2022

Objective

To evaluate the need for cardiac monitoring in unselected patients recovered from COVID-19 and to estimate the risk of heart complications after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

Materials and methods

During March 2020 and January 2021, 106 patients who had recovered from SARS-CoV-2 (alpha and beta variants) were enrolled in prospective observational cohort study CoSuBr (Covid Survivals in Brno). The diagnosis was based on a reverse transcription-polymerase chain reaction swab test of the upper respiratory tract. Demographic parameters, patient history, clinical evaluation, cardiac biomarkers, ECG and echocardiography were recorded during three visits (Visit 1 at least 6 weeks after infection, Visit 2 three months later, and Visit 3 one year after Visit 1).

Results

58.5% of the study group (n = 106) were female, while the mean age was 46 years (range 18–77 years). The mean time interval between the onset of infection and the follow-up visit was 107 days. One quarter (24.5%) of the patients required hospitalization during the acute phase of the disease; the rest recovered at home. 74% suffered a mild form of the disease, with 4.8, 18.1, and 2.9% suffering moderate, severe, and critical forms, respectively. At the time of enrolment, 64.2% of the patients reported persistent symptoms, while more than half of the whole group (50.9%) mentioned at least one symptom of possible cardiac origin (breathing problems, palpitations, exercise intolerance, fatigue). In the 1-year follow-up after COVID-19 infection, left ventricle ejection fraction showed no significant decrease [median (IQR) change was −1.0 (−6.0; 4.0)%, p = 0.150], and there were no changes of troponin (mean change −0.1 ± 1.72 ng/L; p = 0.380) or NT-proBNP [median (IQR) change 2.0 (−20.0; 29.0) pg/mL; p = 0.315]. There was a mild decrease in right ventricle end diastolic diameter (-mean change 2.3 ± 5.61 mm, p < 0.001), while no right ventricle dysfunction was detected. There was very mild progress in left ventricle diastolic diameter [median (IQR) change 1.0 (−1.0; 4.0) mm; p = 0.001] between V1 and V3, mild enlargement of the left atrium (mean change 1.2 ± 4.17 mm; p = 0.021) and a non-significant trend to impairment of left ventricle diastolic dysfunction. There was a mild change in pulmonary artery systolic pressure [median (IQR) change 3.0 (−2.0; 8.0) mmHg; p = 0.038].

Conclusion

Despite a lot of information regarding cardiac impairment due to SARS-CoV2, our study does not suggest an increased risk for developing clinically significant heart changes during the 1-year follow-up. Based on our results, routine echocardiography and biomarkers collection is currently not recommended after COVID-19 recovery.
Breakdown-limited endurance in HZO FeFETs: Mechanism and improvement under bipolar stress
Authors: Toprasertpong Kasidit , Takenaka Mitsuru , Takagi Shinichi
Published: December 2022

Breakdown is one of main failure mechanisms that limit write endurance of ferroelectric devices using hafnium oxide-based ferroelectric materials. In this study, we investigate the gate current and breakdown characteristics of Hf0.5Zr0.5O2/Si ferroelectric field-effect transistors (FeFETs) by using carrier separation measurements to analyze electron and hole leakage currents during time-dependent dielectric breakdown (TDDB) tests. Rapidly increasing substrate hole currents and stress-induced leakage current (SILC)-like electron currents can be observed before the breakdown of the ferroelectric gate insulator of FeFETs. This apparent degradation under voltage stress is recovered and the time-to-breakdown is significantly improved by interrupting the TDDB test with gate voltage pulses with the opposite polarity, suggesting that defect redistribution, rather than defect generation, is responsible for the trigger of hard breakdown.