bluuebunny/crossref_metadata_2025 huggingface dataset:
Analysis of the Impact of Innovative Economic Conditions on the Flow of Workers in the Labour Markets of the European Union Countries
Authors: Węgrzyn Grażyna , Salamaga Marcin
Published: September 2023

The main purpose of the work is to present the results of empirical research on the impact of innovation levels in the economy on the structure of labour market flows. The analysis of the directions and scale of these flows makes it possible to discover important characteristics of the labour market and thus makes it possible to better construct and target policies to reduce unemployment or activate economically inactive people. The study uses data from the Labour Force Survey (LFS) and experimental job‑to‑job statistics for the European Union (EU) countries, covering the 2011–2019 period. We conducted research separately for selected groups of economies classified by their level of innovation, i.e. Innovation Leaders, Strong Innovators, Moderate Innovators, and Emerging Innovators. The results demonstrate that the structure of flows in a labour market depends on the innovation level of the respective economy. The main contribution of the study is that it identifies employee flow patterns in the labour markets of individual EU countries from the perspective of the innovation levels of their respective economies. Panel error correction models (ECM) and panel causality tests were used. In countries that are Innovation Leaders, an increase in participation in lifelong learning leads to a parallel increase in employee flow (EE) and job‑to‑job employee turnover. In countries that are Emerging Innovators, increasing participation in lifelong learning increases turnover, mainly among young people (15–24 age group).
A Reassessment of Oil Market Volatility and Stock Market Volatility: Evidence from Selected SAARC Countries
Authors: Aziz Tariq
Published: September 2023

Volatility spillover informs whether the information in one market impacts the information in another. This paper examines whether oil market volatility spills over to the equity markets of selected SAARC countries. The study uses data from February 2013 to September 2019 to obtain updated evidence about the transmission of global oil price volatility to the equity markets of the SAARC member countries. The bivariate EGARCH model is used to test for volatility transmission from the oil market to the stock market. It is found that oil price shocks do not significantly impact equity market volatility, except in Bangladesh. Policymakers can use these findings when making policy decisions.
ANALYSIS OF THE CLIMATIC DEFLATION INDICATOR DYNAMICS ON THE EXAMPLE OF ERZIN WEATHER STATION DATA
Authors: Kozlova Inga V. , Zenkova Zhanna N. , Kvasnikova Zoya N.
Published: September 2023

Link for citation: Kozlova I.V., Zenkova Zh.N., Kvasnikova Z.N. Analysis of the climatic deflation indicator dynamics on the example of Erzin weather station data. Bulletin of the Tomsk Polytechnic University. Geo Аssets Engineering, 2023, vol. 334, no. 9, рр. 154-162. In Rus.
The relevance of the research is caused by the need to identify factors affecting the development of deflationary processes of arid geosystems of the Tuva Republic. This will allow us to propose further measures to reduce the degradation of agricultural land and minimize the development of land desertification. Objective: assessment of climatic conditions and identification of anthropogenic factors of the potential danger of deflation to monitor changes in vulnerable geosystems and natural and anthropogenic processes. Objects: a section of the north-eastern (Russian) part of the Ubsunur basin within the Erzinsky district of the Tuva Republic. Methods: statistical analysis, regressions, moving average, comparative geographical method, interpretation of satellite images. Results. The dynamics of the climatic index of deflation based on the data of the Erzin weather station for 1966–2020 is analyzed; graphs of changes in the temperature regime, the amount of precipitation, wind speed are plotted; a linear trend of the distribution of the average annual temperature is revealed; coefficients of the climatic index of deflation and aridity indices are determined, graphs of their dynamics for the period under study are plotted; a tendency to weaken deflation is revealed; the studied landscapes are subarid on average, and according to the index fluctuation – from weakly arid (0,6–0,8) to arid (0,3) and subarid (0,5 –0,6).
Impact of Irrigation and Fertigation Levels on Growth, Yield Components and Yield of Aerobic Rice (Oryza sativa L.) under Drip System
Authors: Singh Nunavath Umil , Vaiyapuri K. , Thavaprakaash N. , Selvakumar S. , Vanitha K.
Published: September 2023

Back ground: More than half of the world’s population depends on rice, which is grown in transplanting conditions. Due to the global water crisis, irrigated rice systems are no longer sustainable. Therefore, cultivating aerobic rice with drip irrigation and fertigation meets the crop water and nutrient requirements, results in the optimal yield. Method: A field experiment was conducted during summer 2022 and 2023 at Research Farm of Wetland in Tamil Nadu Agricultural University, Coimbatore, to evaluate the performance of aerobic rice under drip irrigation and fertigation levels on growth and yield of Co-51 variety. The experiment was laid out in randomized complete block design with combination of thirteen treatments, replicated thrice. Results: Among different treatments, drip fertigation @ 100% PE up to 30 DAS+150% PE up to 60 DAS+ 200% PE up to 90 DAS with 125% RDF (25% through NF+75% through WSF) resulted significantly superior growth characters viz., higher plant height (92.54 and 95.95 cm), no. of tiller m-2(469.78 and 478.42), total drymatter production m-2 (988.21 and 1025.42 g m-2), no. of filled grains panicle-1 (107.5 and 114.5), total no. of grains panicle-1 (122.6 and 127.1), fertility percentage (87.7% and 90.1%) and lower no. of ill filled grains panicle-1 (15.1 and 12.6), grain yield (4316 and 4446 kg ha-1) and straw yield (5528 and 5775 kg ha-1) as compared to others, during summer 2022 and 2023, respectively.
STRATEJİK İLETİŞİM YÖNETİMİ KAPSAMINDA KAMU KURUMLARININ STRATEJİK PLANLARINDA İLETİŞİM ve HALKLA İLİŞKİLER: BAKANLIKLAR ÜZERİNE BİR İNCELEME
Authors: YILDIRIM Ali
Published: September 2023

tratejik iletişim, günümüzde her kurum ve kuruluş için hedef kitlelerle iletişime geçmek ve onlarla stratejik düzeyde ilişki kurmak için önemli bir enstrümandır. Kamu kurumlarının da iletişimi bir amaç olarak benimseyip paydaşlarıyla stratejik ilişki kurmak için kullanması gerekmektedir. Bu çalışmanın amacı, Türkiye Cumhuriyeti Cumhurbaşkanlığına bağlı Bakanlıkların stratejik planlarında iletişimin bir amaç, hedef veya strateji olarak nasıl ele alındığını tespit etmek ve iletişimin önemini ortaya koymaktır. Araştırmada içerik analizi tekniği kullanılmıştır. Bu doğrultuda, Bakanlıkların stratejik planları resmi örün sayfaları aracılığıyla toplanmıştır. Toplanan iletişim planları Microsoft Office Excel yardımıyla kategori haline getirilmiştir. Her bir bakanlığın stratejik amacı, hedefi ve hedef doğrultusunda belirlediği stratejileri kategorilere ayrılarak tanımlanmıştır. Tanımlanan amaç ve hedefler, iletişim çerçevesinde incelenmiştir. Elde edilen bulgularda, bakanlıkların stratejik planlarında iletişime amaç, hedef ve stratejiler düzeyinde yer verdiği; fakat sadece 4 bakanlığın iletişimi amaç düzeyinde belirlediği tespit edilmiştir. Bakanlıkların iletişimi çoğunlukla teknik düzeyde bir araç olarak tercih ettiği ortaya çıkmıştır. Elde edilen bulgulara bakıldığında, bir bakanlığın stratejik planına ulaşılamamış, bir bakanlık da iletişime hiç yer vermemiştir. Her bir bakanlığın iletişimi stratejik düzeyde benimsemesi gerektiği, stratejik planlarına amaç ve hedef düzeyinde dahil etmesi gerektiği sonucuna ulaşılmıştır.
Türk Medyasının Depremle İmtihanı: Kahramanmaraş Depremini Afet Haberciliği Üzerinden Değerlendirmek
Authors: BUDAK Emrah
Published: September 2023

Afet dönemlerinde toplumun bilgi ihtiyacını karşılayan, koordinasyon sağlayan medya kuruluşlarının felaketler süresince söz konusu bölgeye dair ürettiği içerikler afet haberciliği çerçevesinde ele alınmaktadır. Doğal afetlerin yarattığı hasarların azaltılması, toplumun doğru bir biçimde bilgilendirilmesi konusunda haber medyasına önemli bir sorumluluk düşmektedir. Haber medyasının kamusal yararı gözeten bilim temelli bir afet haberciliği yürütmesi konusunda ne denli başarılı olduğu tartışmalıdır. Bu bağlamda çalışmada Türk medyasında farklı editöryal tutumu benimseyen gazetelerin Kahramanmaraş’ta yaşanan depreme ilişkin ürettiği haberler (n: 3329) afet haberciliği çerçevesinde nitel ve nicel içerik analizi yöntemi ile incelenmiştir. Çalışmadan elde bulgular; Türk medyasının depremi politik, duygusal bir bakış açısı ile değerlendirdiğini göstermiştir. Bununla birlikte Türk medyasının depreme dair nitelikli bir afet haberciliği yürütemediği kavranmış, bilimsel ve derinlemesine incelenen bir anlayıştan ziyade felaket odaklı bir yaklaşımı benimsediği ortaya konmuştur.
Comprehensive child safety is a new type of national security in the strategic planning system
Authors: Kolotkina Oksana А. , Yagofarova Inara D.
Published: September 2023

The article presents a theoretical and legal analysis of the concept of “comprehensive child safety”, which is new to Russian legislation, and is enshrined in the Strategy of comprehensive child safety in the Russian Federation for the period up to 2030, approved by the President of the Russian Federation Decree no. 358 of May 17, 2023. It is emphasized that it is necessary to develop a definition of “comprehensive safety” concept at the doctrinal level due to the absence of an appropriate prescription establishing its content in the strategic planning document itself. The purpose of the research is to determine the content of “comprehensive child safety” concept to substantiate the possibility of considering the latter as a separate type of national security focused on specific strategic national interests’ implementation stated in the National Security Strategy 2021. Comprehensive child safety is an individual security integral part as a whole, but at childhood development stage. Ensuring the child safety issues in an integrated relationship with national interests, strategic national priorities and strategic planning as a whole are not studied at the doctrinal level and require theoretical development. General scientific and private scientific methods, including special legal ones, were used as research methods. The main research methods used are analysis, comparative legal and formal legal methods. Based on the strategic planning documents’ analysis, the author’s definition of “comprehensive child safety” concept is formulated, its content elements are indicated. The conclusion is made that the main purpose of ensuring the comprehensive child safety is to achieve the unhindered realization by minors of their rights and legitimate interests provided by current legislation norms. Ensuring such a state will allow achieving the harmonious development of the child as a person in the future.
ROLE OF LEADER IN EDUCATIONAL MANAGEMENT
Authors:   PhD Student, Business Administration, Georgian American University, IMS Manager, Independent Auditor of Management Systems and Occupational Health and Safety, Tbilisi, Georgia, Chkheidze Salome
Published: September 2023

The main objective of this article is to describe a role of leader and define its importance in educational management. The role of a leader in educational management is critically important to make the educational institution provide high-quality education to students, to create an effective management system and motivate the staff to go towards the aim (Eacott, 2015). On the educational context, leadership influences the process, which finally leads to the achievement of desired purpose. A good leader should develop a vision on values of their educational institutions on personal and professional sides. A successful leader makes the staff love their job and be determined to achieve success. Educational leadership is a process, where a leader takes the initiative to facilitate the following conditions for implementing change in teaching and learning (Surya, 2011). The leader in educational leadership is responsible for setting the vision and mission of the educational institution, which serves as a guiding principle for all stakeholders, including students, teachers, and staff. Moreover, the leader must ensure that the educational institution environment is conducive to learning, which includes creating a safe and respectful atmosphere for students and teachers.
Real-time quality control for chemical and biotechnological processes: a brief review
Authors: Kołodziejczak-Radzimska Agnieszka , Rukowicz Beata , Davin Sharon
Published: September 2023

Monitoring critical process parameters of chemical and biotechnological processes is an essential tool at every stage of drug manufacturing technology. The aim of Process Analytical Technology (PAT) is to provide effective tools, such as multidimensional data analysis, modern analytical methods, and monitoring tools, for the continuous improvement of process understanding and knowledge. Among the methods of wide interest are optical and spectroscopic techniques that can be used in the control of chemical and biotechnological processes. The selection of the appropriate method is crucial and depends on many factors, including the nature of the process, the number of variables, and analytical limitations. This review focuses on a brief and precise characterization of spectroscopic and optical methods that can be applied to monitoring and control of chemical and biotechnological processes.
Test of Volatile Behaviors with the Asymmetric Stochastic Volatility Model: an Implementation on nasdaq-100
Authors: Suleymanov Elchin , Gubadli Magsud , Yagubov Ulvi
Published: September 2023

ABSTRACT
The present study aimed to investigate the presence of asymmetric stochastic volatility and leverage effects within the Nasdaq-100 index. This index is widely regarded as an important indicator for investors. We focused on the nine leading stocks within the index, which are highly popular and hold significant weight in the investment world. These stocks are Netflix, PayPal, Google, Intel, Microsoft, Amazon, Tesla, Apple, and Meta. The study covered the period between 03/01/2017 and 30/01/2023, and we employed the Eviews and WinBUGS applications to conduct the analysis.
We began by calculating the logarithmic difference to obtain the return series. We then performed a sample test with 100,000 iterations, excluding the first 10,000 samples to eliminate the initial bias of the coefficients. This left us with 90,000 samples for analysis. Using the results of the asymmetric stochastic volatility model, we evaluated both the Nasdaq-100 index as a whole and the volatility persistence, predictability, and correlation levels of individual stocks. This allowed us to evaluate the ability of individual stocks to represent the characteristics of the Nasdaq-100 index.
Our findings revealed a dense clustering of volatility, both for the Nasdaq-100 index and the nine individual stocks. We observed that this volatility is continuous but has a predictable impact on variability. Moreover, with the exception of Intel, all the stocks in the model exhibited both leverage effects and the presence of asymmetric relationships, as did the Nasdaq-100 index as a whole. Overall, our results show that the characteristics of stocks in the model are similar to the volatility characteristic of the Nasdaq-100 index and have the ability to represent it.
SARS-CoV-2 phoenix: Empirical formulas and thermodynamic properties (enthalpy, entropy and Gibbs energy) of nucleocapsid, virus particle and biosynthesis of BA.2.86 Pirola variant
Authors: Popović Marko E. , Šekularac Gavrilo , Popović Marta
Published: September 2023

Similarly to a phoenix, SARS-CoV-2 has appeared periodically in waves. The new variants that appeared through mutations have during the 4 years of the pandemic suppressed earlier variants, causing new waves of the pandemic. The Omicron BA.2.86 Pirola variant is the latest in the sequence of SARS-CoV-2 variants, which appeared in 2023. The BA.2.86 variant has started to spread rapidly and we are witnesses of a new epidemic wave. In this short period, an increased infectivity was noticed, which results in rapid spreading and decreased pathogenicity, which results in a lower number of severe cases. However, in the public there is a fear of further development of the epidemic. This analysis was made with the goal to assess the risks in the period of late 2023. Mutations that were developed by the BA.2.86 variant have led to a change in empirical formula and thermodynamic properties. It seems that there is no ground for fear of an extensive spreading of severe forms, but there are reasons for caution and monitoring of the spreading of the epidemic and potential appearance of new mutations.
A Comprehensive Analysis of the Public Discourse on Twitter about Exoskeletons from 2017 to 2023
Authors: Thakur Nirmalya , Patel Kesha A. , Poon Audrey , Shah Rishika , Azizi Nazif , Han Changhee
Published: September 2023

The work of this paper presents multiple novel findings from a comprehensive analysis of about 150,000 tweets about exoskeletons posted between May 2017 and May 2023. First, findings from content analysis and temporal analysis of these tweets reveal the specific months per year when a significantly higher volume of Tweets was posted and the time windows when the highest number of tweets, the lowest number of tweets, tweets with the highest number of hashtags, and tweets with the highest number of user mentions were posted. Second, the paper shows that there are statistically significant correlations between the number of tweets posted per hour and different characteristics of these tweets. Third, the paper presents a multiple linear regression model to predict the number of tweets posted per hour in terms of these characteristics of tweets. The R2 score of this model was observed to be 0.9540. Fourth, the paper reports that the 10 most popular hashtags were #exoskeleton, #robotics, #iot, #technology, #tech #innovation, #ai, #sci, #construction and #news. Fifth, sentiment analysis of these tweets was performed using VADER and the DistilRoBERTa-base library. The results show that the percentage of positive, neutral, and negative tweets were 46.8%, 33.1%, and 20.1%, respectively. The results also show that in the tweets that did not express a neutral sentiment, the sentiment of surprise was the most common sentiment. It was followed by the sentiments of joy, disgust, sadness, fear, and anger. Furthermore, analysis of hashtag-specific sentiments revealed several novel insights, for instance, for almost all the months in 2022, the usage of #ai in tweets about exoskeletons was mainly associated with a positive sentiment. Sixth, text processing-based approaches were used to detect possibly sarcastic tweets and tweets that contained news. Finally, a comparison of positive tweets, negative tweets, neutral tweets, possibly sarcastic tweets, and tweets that contained news, in terms of different characteristic properties of these tweets are presented. The findings reveal multiple novel insights, for instance, the average number of hashtags used in tweets that contained news has considerably increased since January 2022.
Impact on Food of Uranium and Heavy Metals Mining Activities
Authors: Radu Violeta Monica , Popescu (Hoștuc) Ioana Carmen , Banu Diana Maria , Zlăgnean Marius , Tomuș Nicolae
Published: September 2023

The rapid technological development of society determined increased demand for safe potable water and food resources. Unfortunately, this progress causes complex environmental pollution, that is continuously challenging the scholars’ community. Therefore, it is important to chemically analyze the food for a better understanding of pollution-spreading mechanisms. Our study is focused on food analysis originating from Vatra Dornei City, which belongs to Suceava County in the Bukovina region of Romania. It represents a well-known Romanian spa and ski resort in the northern parts of the Oriental Carpathians Mountains. The mountain region owns a lot of mineral resources, mainly consisting of mineral and sparkling waters, uranium, manganese, copper, pyrite, chalcopyrite, polymetallic ores, baryte, gold and silver-bearing orebodies, etc. The present contribution aims to point out the results obtained from the analysis of soil, water and food samples collected from the local markets. The food samples consisted of lettuce, spinach, apples, pork (smoked) chicken meat (raw), milk and cheese. Last year the survey was conducted over six months. The results highlighted that the mining activities carried out during time caused environmental pollution with uranium and heavy metals due to the waste heaps’ weathering phenomena and tailing ponds’ presence.
Integration of Metabolomics and Transcriptomics to Explore Dynamic Alterations in Fruit Color and Quality in ‘Comte De Paris’ Pineapple during Ripening Processes
Authors: Song Kang Hua , Liu Jia Meng , Yao Quan Sheng , Li Yi Xing , Hou Xiao Wan , Liu Sheng Hui , Qiu Xun Xia , Yang Yue , Chen Li , Hong Ke Qian , Lin Li Jing , Zhang Xiu Mei
Published: September 2023

To understand the molecular mechanism underlying yellowing in pineapples during ripening, coupled with alterations in fruit quality, comprehensive metabolome and transcriptome investigations were carried out. These investigations were conducted using the pulp samples collected at three distinct stages of maturity: young fruit (YF), mature fruit (MF), and fully mature fruit (FMF). This study revealed a noteworthy increase in the levels of total phenols and flavones, coupled with a concurrent decline in lignin and total acid content, as the fruit transitioned from YF to FMF. Furthermore, the analysis yielded 167 differentially accumulated metabolites (DAMs) and 2194 differentially expressed genes (DEGs). Kyoto Encyclopedia of Genes and Genomes enrichment analysis based on DAMs and DEGs revealed that the biosynthesis of plant secondary metabolites, particularly the flavonol, flavonoid, and phenypropanoid pathways, plays a pivotal role in fruit yellowing. Additionally, a comprehensive regulatory network encompassing genes that contribute to metabolisms of flavones, flavonols, lignin, and organic acids was proposed. This network sheds light on the intricate processes that underlies fruit yellowing and quality alterations. These findings enhance our understanding of the regulatory pathways governing pineapple ripening and offer valuable scientific insight into the molecular breeding of pineapples.
Urinary L-FABP, a Biomarker for Disease Progression, Dialysis and Overall Mortality in Chronic Kidney Disease
Authors: Mitsides Nicos , Mitra Vikram , Saha Ananya , Harris Shelley , Kalra Philip A. , Mitra Sandip
Published: September 2023

Chronic Kidney Disease (CKD) is a major public health concern with an increasing proportion of sufferers progressing to renal replacement therapy (RRT). Early identification of those at risk of disease progression could be key in improving outcomes. We hypothesise that urinary liver-type fatty acid binding protein (uL-FABP) may be a suitable biomarker for CKD progression and can add value to currently established biomarkers such as urinary protein to creatinine ratio (uPCR)

583 participants with CKD 1-5 (not receiving renal replacement therapy) entered a 2-yr prospective longitudinal study. UPCR and uL-FABP were measured at baseline and CKD progression was defined as either i) a decline in eGFR of >5ml/min/1.73m2 or an increase in serum creatinine by 10% at 1-yr or ii) a decline in eGFR of >6 ml/min/1.73m2, or an increase in serum creatinine by 20% at 2-yrs or iii) the initiation of RRT. A combined outcome of initiating RRT or death was also included.

Approximately 40% of participants showed CKD progression. UL-FABP predicted CKD progression at both years 1 and 2 (OR 1.01, p<0.01). Sensitivity and specificity were comparable to those of uPCR (AUC 0.623 v 0.706) and heat map analysis suggested that uL-FABP in the absence of significant proteinuria can predict an increase in serum creatinine of 10% at 1yr and 20% at 2yr. The risk of the combined outcome of initiating RRT or death was 23% higher in those with high uL-FABP (p<0.01) independent of uPCR.

UL-FABP appears to be a highly sensitive and specific biomarker of CKD progression. The use of this biomarker could enhance the risk stratification of CKD and its progression and should be assessed further.
Effects of Land Use Characteristics, Physiochemical Variables and River Connectivity on Fish Assemblages in a Lowland Basin
Authors: Zhang Zhiming , Gao Junfeng , Cai Yongjiu
Published: September 2023

Human disturbances can have severe environmental impacts on freshwater ecosystems. The main aim of this study was to detect the influences of physiochemical variables, land-cover characteristics, and river connectivity on fish assemblages in Lake Chaohu Basin, China. A cluster analysis of the river connectivity variables identified four groups of sites that characterized by significantly different connectivity gradients in local scale. These four groups of sites showed increasing connectivity from the upper reaches to the lower reaches. At the same time, among the four groups, the values of the environmental variables generally increased from the upper reaches with less human activity towards the lower reaches with more human activities. For instance, some main physiochemical variables (e.g., river width, water depth, nitrate, phosphate) significantly increased among the four groups. In contrast, fish taxa richness and diversity indices were not significantly different among the four connectivity groups. However, fish assemblages showed significant variation among the connectivity groups (p=0.026). In addition, the study determined that upper riparian land uses (e.g., woodland and grassland), flow velocity, and elevation were environmental variables regulating the variance in the fish communities, and for the connectivity variables, only river order and number of branches along a path to the left of the main stem affected the variance in the fish communities. Therefore, new practices aimed at maintaining and even increasing the riparian canopy coverage and the flow velocity of rivers should be integrated into local conservation planning for freshwater ecosystems, especially in the upper reaches of the basin.
D2MFNet: a Dual-Domain Multi-Frequency Network for Side-Scan Sonar Image Detection
Authors: Wang Wen , Zhang Yifan , Li Houpu , Gong Xue , Liu Lei , Kang Yixin
Published: September 2023

The utilization of side-scan sonar (SSS) technology plays a pivotal role in ensuring the safety of underwater environments and facilitating the discovery of aquatic resources during daily production activities. Within this field, the use of SSS images for seabed target detection has gained widespread recognition. However, many existing detection approaches primarily concentrate on tracking the evolution path of optical image object detection tasks, resulting in complex structures and limited versatility. To tackle this issue, we introduce a pioneering Dual-Domain Multi-Frequency Network (D2MFNet) meticulously crafted to harness the distinct characteristics of SSS image detection.
To maximize the information extracted from SSS images across various frequency ranges, we introduce a novel method for calculating the information flow of target ranges and propose a Multi-Frequency Combined Attention Mechanism (MFCAM). This mechanism amplifies the relevance of dual-domain features across different channels. Moreover, recognizing that SSS images can provide richer insights after frequency domain conversion, we introduce a Dual-Domain Feature Pyramid Network D2FPN. By incorporating frequency domain information representation, D2FPN significantly augments the depth and breadth of feature information in underwater small datasets.
Our methods are seamlessly designed for integration into existing networks, offering plug-and-play functionality with substantial performance enhancements. We have conducted extensive experiments to validate the efficacy of our proposed techniques, and the results showcase their state-of-the-art performance. We will make our code and models publicly available at https://dagshub.com/estrellaww00/D2MFNet.
Experimentation of a PVA-Borax hydrogel for the removal of Paraloid B72® from artifacts of archaeological interest from the National Archaeological Museum in Naples, Italy
Authors: Altobelli Annarita , Cennamo Paola , Trojsi Giorgio , Barone Lumaga Maria Rosaria , Carpentieri Andrea , Fatigati Giancarlo
Published: September 2023

This paper shows the results of an experimentation aimed at the removal of a polymeric film of aged Paraloid B72® originally placed to protect some wooden artifacts belonging to the Egyptian collection of the National Archaeological Museum of Naples (MANN). The study was conducted on two shabtis dated to the 19th Dynasty and a sculpture of Ptah-Sokar-Osiris dating to the late period. Thanks to the collaboration between the National Archaeological Museum of Naples and the Laboratory of Restoration of Wooden Artifacts of the University of Naples Suor Orsola Benincasa, it was possible to conduct an in-depth study of the artifacts, from both an archaeological-historical point of view and from a conservation point of view. This led to the development of the above-mentioned experimentation and to the planning of a proper restoration intervention. The study and experimentation were supported by several diagnostic techniques. In a first stage, non-invasive investigations were carried out to study the execution technique and the state of conservation of the artifacts. This allowed the recognition of the wood species that constituted the three sculptures through optical microscopy, whereas IR reflectography, UV induced fluorescence and X-ray radiation (XRF) were conducted to identify the type and the chemical nature of the pigments. Based on the above analysis, different restoration strategies, based on the removal of Paraloid B72® through a methodology that would act in full respect of the wooden support of the artifacts, were considered. Pros and cons of the different methodologies applied in the recent past for the removal of aged Paraloid from artifact surfaces were analysed. A removal technique based on the use PVA-Borax hydrogel loaded with a solvent mixture was selected. Experiments were conducted to validate the effectiveness of the selected method.
Combining SIRI and AFR to predict early serious complications and recurrent or metastases after respectable gastric cancer
Authors: Ren Jingyao , Wang Da , Zhu Lihui , Liu Shuo , Yu Miao , Cai Hui
Published: September 2023

Aims. The aim of this study was to assess the clinical importance and prognostic significance of systemic inflammatory response index (SIRI) and the albumin fibrinogen ratio (AFR) on early postoperative outcomes in patients undergoing radical gastric cancer surgery.
Methods. We conducted a retrospective analysis of the clinicopathological characteristics and relevant laboratory indices of 568 patients with gastric cancer. We examined the diagnostic ability of the combination of SIRI and AFR for early postoperative serious complications. We compared three groups of patients to evaluate the prognostic value of various preoperative SIRI-AFR scores for early postoperative recurrence or metastasis.
Results. The results demonstrated that the SIRI-AFR score was an independent risk factor for early postoperative recurrence or metastasis and had the highest diagnostic power for early serious complications in patients with gastric cancer.
Conclusion. Preoperative SIRI and AFR were significantly associated with early postoperative recurrence or metastasis and the occurrence of severe complications in patients with gastric cancer.
Harnessing the Potential of Exosomal miRNAs: A Breakthrough in Rheumatoid Arthritis Diagnosis and Monitoring
Authors: Gong Jianmin , Zhang Xiaoshan , Khan Adeel , Liang Jun , Xiong Tao , Yang Ping , Li Zhiyang
Published: September 2023

Background
Rheumatoid arthritis (RA) is an autoimmune disorder characterized by the inflammation-induced joint damage. Timely diagnosis and treatment are crucial to prevent lasting disability. Here, we aim to evaluate whether exosomal miRNAs could serve as promising biomarkers for expeditious RA diagnosis and effective therapy.
Methods
First, we performed small RNA sequencing to determine the miRNA profiles of serum exosomes within a screening cohort comprising 18 untreated active RA patients, along with 18 age and gender-matched healthy controls. Subsequently, the miRNA profiles were then validated in a training cohort consisting of 24 RA patients and 24 healthy controls, using RT-qPCR methodology. Finally, the selected exosomal miRNAs were subjected to validation in a larger cohort comprising 108 RA patients and 103 healthy controls. The diagnostic efficacy of the exosomal miRNAs was evaluated by receiver operating characteristic (ROC) curve analysis. The biological functions of the miRNAs were determined by gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses.
Results
Our results first demonstrated a noteworthy upregulation of three specific miRNAs (miR-885-5p, miR-6894-3p, and miR-1268a) in the serum exosomes of patients of RA patients as compared with healthy controls. The combination of three miRNAs along with Anti-Cyclic Citrullinated Peptide Antibodies (ACPA) exhibited excellent diagnostic accuracy, yielding an area under the curve (AUC) of 0.963 (95% confidence interval = 0.941–0.984), a sensitivity of 87.96%, and a specificity of 93.20%. Notably, miR-885-5p exhibited remarkable discriminatory capacity by itself indistinguishing ACPA- negative RA patients from healthy controls, with an AUC of 0.993 (95% CI = 0.978-1), a sensitivity of 96.67%, and a specificity of 100%. Moreover, in the assessment of therapeutic effectiveness, the expression of miR-1268a displayed a significant reduction on the 29th day of MTX treatment in RA patients. This decline in expression paralleled the trends observed in TJC28 (28-joint tender count), SJC28 (28-joint swollen count), and DAS28-CRP (Disease Activity Score with 28-joint count using C-Reactive Protein), all of which are indicative of RA disease activity. Finally, predictive analysis indicated that all three exosomal miRNAs target pivotal signaling molecules involved in inflammatory pathways, thereby demonstrating effective modulation of the immune system.
Conclusions
In this study, we have successfully demonstrated the promising potential of serum exosomal miRNAs, particularly miR-885-5p, miR-6894-3p and miR-1268a, hold promising potential as biomarkers for the early diagnosis and prediction of RA for the first time. These findings highlight the importance of exosomal miRNAs in the realm of RA diagnosis and disease monitoring.
Medicinal Plant-based Biologically Active Substances and Extracts Inhibit Intestinal Autofluorescence Accumulation in Caenorhabditis elegans
Authors: Salimon Saoban Sunkanmi , Marusich Elena Ivanovna , Leonov Sergey Victorovich
Published: September 2023

Aging is a complex process related with the gradual diminution in cellular and physiological functions. The geroprotective effect of 10 biologically active substances (BAC – rutin, squalene, kaempferol, biohanin A, urosolic acid, chlorogenic acid, baicalin, mangiferin, quercetin and trans-cinnamic acid) and 5 crude extracts (Ginkgo biloba, Pulmonaria officinalis, Scutellaria baicalensis, Hedysarum neglectum and Panax ginseng) isolated from medicinal plants of Altai Region of Russia were evaluated for their influence on the accumulation of intestinal autofluorescence material (IAM) using Caenorhabditis elegans model. Gravid nematodes were synchronized, and then seeded in 96-well plates to develop to L4-stage. Each BAC in 200 µmol, 100 µmol, 50 µmol and 10 µmol concentrations and extracts with a tenth, hundredth and thousandth times-dilution were administered to each well in 6 replicates for each treatment group. On incubation days 1, 5, and 15, adult L4 nematodes underwent spectrofluorometric analysis to determine the effect of the BACs and extracts on IAM accumulation. It was found that quercetin, kaempferol, baicalin, mangiferin, Ginkgo biloba and Panax ginseng extracts exhibited the most profound inhibition of IAM accumulation compared to the control. Thus, they can be considered as important precursors or active ingredients for the pharmacosynthesis of geroprotective drugs in future research.
Efficacy of Supervised Self-Reduction vs Physician-Assisted Techniques for Anterior Shoulder Dislocations: A Systematic Review and Meta-Analysis
Authors: Hoveidaei Amir Human , Dankoub Mahdi , Nasab Mohammad Mehdi Mousavi , Ansari Amin Nakhostin , Pouramini Alireza , Eghdami Shayan , behbahani Fatemeh Mashaknejadian , Zangiabadian Moein , Forogh Bijan
Published: September 2023

background: The purpose of this study is to compare the efficacy of supervised self-reduction procedures versus physician-assisted techniques for treating anterior shoulder dislocations.
Method: We conducted a comprehensive search on PubMed, Scopus, Web of Science, and Cochrane up to March 22, 2023, using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) checklist. Relevant articles were reviewed, with a focus on studies comparing supervised self-reduction techniques to physician-assisted techniques in cases of anterior shoulder dislocation.
Results: The meta-analysis included four studies, with 283 patients in the physician-assisted group and 180 patients in the supervised self-reduction group participating. The success rate of supervised self-reduction techniques was significantly higher, with an odds ratio of 2.71 (95% CI 1.25-5.58, p-value = 0.01). Based on the Visual Analog Scale (VAS) score, the physician-assisted group reported significantly higher maximum pain, with a mean difference of 1.98 (95% CI 1.24-2.72, p-value < 0.01).
Conclusion: Supervised self-assisted techniques outperform in terms of success rate and reduction-related maximum pain. These techniques could be used as an effective first-line treatment for anterior shoulder dislocation, potentially reducing the need for analgesics and emergency room visits.
Pingchan Granule for objective and subjective insomnia in Parkinson's Disease: a multicentre, randomized, controlled, double-blind trial
Authors: Gu Sichun , Yin Ping , Cao Yang , Shi Rong , Li Qiang , Liu Jun , Wu Yun-Cheng , Zhang Yu , Wang Chang-De , Zhang Yun-Yun , Gu Min-Jue , Xu Li-Min , Gao Chen , Yuan Xiao-Lei , Wu You , Hu Yu-Qing , Yuan Canxing , Ye Qing
Published: September 2023

Background
Insomnia is a common and disabling nonmotor manifestation of Parkinson’s disease (PD). Drugs improving both parkinsonism and sleep would be of great benefit to patients with PD-related insomnia. Pingchan granule (PCG) is a traditional Chinese medicine for PD. The objective of this study was to test the efficacy and safety of PCG for insomnia associated with PD.
Methods
In this multicenter, randomized, double-blind, placebo-controlled trial, 100 participants were included and followed for 16 weeks (12-week treatment, 4-week follow-up after intervention), randomly assigned to receive PCG or placebo at a 1:1 ratio. The primary outcome was subjective PD-related insomnia evaluated by Parkinson’s disease sleep scale 2 (PDSS-2) score. Secondary outcomes included objective parameters of nighttime sleep by polysomnography and serum biomarker. As secondary outcomes, we also evaluated Insomnia Severity Index (ISI) score, Epworth Sleepiness Scale (ESS) score, rapid eye movement sleep behaviour disorder screening questionnaire (RBDSQ) score, Movement Disorder Society Unified Parkinson’s Rating Scale (MDS-UPDRS) I, II,and III scores, and Parkinson's disease questionnaire (PDQ-39) score. Assessments were conducted at baseline (T0), week 4 (T1), week 8 (T2), week 12 (T3) and week 16 (T4).
Results
The PCG group had significantly greater amelioration in PDSS-2 score than placebo group, as well as its domain scores of overall quality of night’s sleep, sleep onset and maintenance insomnia, nocturnal restlessness, nocturnal psychosis, nocturnal motor symptoms, and daytime dozing. PCG was associated with significant improvement in sleep efficiency, N3 sleep time, total sleep time, and interleukin (IL)-2/IL-4 ratio. Improvements of ISI, ESS, RBDSQ, MDS-UPDRS I, II, III, and PDQ-39 scores were also observed in PCG group compared with the placebo group
Conclusions
This trial provided class I evidence for the efficacy of PCG in treating insomnia in PD according to a wide range of subjective and objective sleep parameters with good tolerance, supporting that PCG might be a viable alternative in the management insomnia in PD.
Trial registration:
Chinese Clinical Trial Register, ChiCTR-INR-17011949 (11/07/2017).
The Effect of Formal Education on Ovarian Cancer and Clinical Trial Awareness Among Black and Latino US Women: The Promising Role of Annual Women’s Wellness Visits to Improve Health Literacy
Authors: Bakaj Amonda , Bakaj Angela , Lekaj Klaudi , Nwokeleme Treasure , Onigbinge Victoria , Gonzalez Indiara , Muyah Cynthia , Muyah Fanesse , Rocheburn Brianna , Ureta Elsie , Equils Ozlem
Published: September 2023

Background
Ovarian Cancer (OC) is ranked as one of the deadliest women’s cancers in the United States. Due to non-specific symptoms, it is often misdiagnosed and detected late. The mortality rate is higher and increasing among Black women. In addition, Black women have poor rates of participation in clinical trials.
Methods
We conducted a survey study among Black and Latino US women to understand the factors influencing their understanding of genetic risks of OC, clinical trial awareness and ability to access a clinical trial. MiOra health educators developed a SurveyMonkey-based survey and administered it to 226 women between the ages of 18 and 65 anonymously in their communities in three large US cities: Houston, TX, Atlanta, GA and Los Angeles, CA. The data was analyzed using two-sided Fisher’s exact and Chi-square tests.
Results
Out of the 226 respondents 63.4% were 30 years of age or younger and 22.9% had lower education (defined as having completed high school education or less. Out of 109 respondents, 93 (85.3%) self-identified as Black or Latino. Age did not influence self-reported awareness of genetic risk for OC, clinical trials or how to locate a clinical trial (Table 1). Lower education women were significantly less likely to report being knowledgeable about the genetic risk factors of OC, clinical trials or locating clinical trials (Table 1). Thirty out of 48 (62.5%) responding lower education women and 118 out of 173 (68.2%) responding higher education women reported to have an annual provider visit (p > 0.05). Self-reported awareness on how to locate a clinical trial was low in both the lower education (3 out of 48, 6.2%) and higher education groups (34 out of 171, 19.9%, p <0.05, Table 1).
Conclusions
These results suggest that the level of formal education influences the Black and Latino women’s awareness of OC genetic risk factors, OC clinical trials and clinical trial access. However, even among college educated Black and Latino women only a small portion reported to know how to locate a clinical trial. Interestingly, both high and lower education Black and Latino women reported to comply with annual provider visits. These visits may be an opportunity to close the health-literacy disparities in OC and clinical trials for Black and Latino women.
Clinical characteristics and managment of patient with portal hypertension at tertial level hospital in Tanzania
Authors: Itule Paul william , Mwanga Ally , Ramadhani Khamis , Byomuganyizi Moses , lutege william , Kagaruki Tryphone Buchard
Published: September 2023

Background
Portal hypertension is a common diagnosis in Sub-Saharan African countries, with the majority of patients presenting late. This study aimed to understand Clinical characteristics, etiology, the treatment offered in our setting, and factors associated with portal hypertension at a tertiary level hospital, in Tanzania.
Methodology:
A prospective cross-sectional observational single hospital-based study was conducted at MNH, from May 2021 to April 2022. A minimum of 152 subjects were required with an error of less than 5% and a study power of 80% at a 95% confidence interval. A structured questionnaire was used to collect data. Ethical clearance was obtained from the MUHAS/MNH IRB.
Results
A total of 154 eligible participants consented and participated in this study. The mean age of participants was 42 ± 15.8 years (range 2–87). The majority of the study participants were males 64.9% with a male to female (M: F) ratio of 1.8:1. Vomiting blood was the common symptom among the study participants 51.3%. Schistosomiasis 53.9% and viral infection 26.6% were the common etiologies followed by alcohol abuse 7.8%. Most were medically treated at 89.61% followed by radiological treatment at 8.44% while only 1.95% of patients received surgical treatment. There was a significant association between the grade of esophageal varices and bleeding consequences (p-value < 0.01).
Conclusion
The majority of patients were medically treated while patients who require surgical care are unable to assess it. We recommend the establishment of a transplant services program to counteract the unmet need and more retrospective research toward policy establishment.
A two-sequence motif-based method for the inventory of gene families in fragmented and poorly annotated genome sequences
Authors: Nørrevang Anton Frisgaard , Shabala Sergey , Palmgren Michael
Published: September 2023

Databases of genome sequences are growing exponentially, but, in some cases, assembly is incomplete and genes are poorly annotated. For evolutionary studies, it is of interest to identify all members of a given gene family in a genome. In this work, we developed a method for identifying most, if not all, members of a gene family from a raw genomes in which assembly is of low quality, using the P-type ATPase superfamily as an example. The method is based on the translation of an entire genome in all six reading frames and the co-occurrence of two family-specific sequence motifs that are in close proximity to each other. To test the method's usability, we first used it to identify P-type ATPase members in the high-quality annotated genome of barley (Hordeum vulgare). Subsequently, after successfully identifying plasma membrane H+-ATPase family members (P3A ATPases) in various plant genomes of varying quality, we tested the hypothesis that the number of P3A ATPases correlates with the ability of the plant to tolerate saline conditions. In 19 genomes of glycophytes and halophytes, the total number of P3A ATPase genes was found to vary from 7 to 22. Taken together, the method developed proved useful for identification of P-type ATPase family members in raw genomes that are poorly assembled.