bluuebunny/crossref_metadata_2025 huggingface dataset:
Machine Learning-Powered Identification of Source Code Vulnerabilities
Authors: Purushottam Borse  , Rushabh Gangurde  , Chaitanya Joshi  , Prof. N.V. Kapade
Published: October 2023

These methods for identifying source code defects face limitations, including false positives and negatives, resource demands, and integration issues in modern software projects. This article explores cutting-edge research in using ML to enhance source code security. As ML gains traction in bug prediction, numerous studies investigate its potential. This research contributes to the growing interest in applying ML to source code, addressing the need for more efficient, accurate, and scalable defect detection methods. By leveraging ML techniques, software development processes can become more robust, reducing vulnerabilities and enhancing overall code quality.
Analisis Sistem Penanganan Pencegahan Tumpahan Minyak Di MV. Mariwit
Authors: Moh Aziz Rohman  , Eva Susanti P
Published: October 2023

Tujuan dengan dilatar belakangi permasalahan pencemaran lingkungan khususnya pada dunia maritim yang semakin merebak, maka kami berupaya mengangkatnya ke penelitian yang berjudul analisis system penanganan pencegahan tumpahan minyak yang berdasarkan aturan yang berlaku yaitu marpol 78/78. Penelitian ini dilakukan di MV Mariwit. Penelitian ini dilakukan selama 15 bulan 9 hari tehitung dari tanggal 30 November 2020. Metode penelitian yang digunakan yaitu kualitatif, dengan pengambilan data melalui Field Research yang meliputi observasi dan wawancara dibantu dengan Library Research dan Internet Research. Hasil yang diperoleh penelitian ini adalah kurangnya perawatan pada perangkat-perangkat bongkar muat sehingga seringnya terjadi tumpahan minyak di kapal serta rendahnya kesadaran awak kapal dalam penanganan tumpahan minyak terutama menaati tugas dan tanggungjawabnya dalam sijil rencana keadaan darurat pencemaran minyak di laut (SOPEP).
Campaigning Europe
Authors: Gjuričová Adéla
Published: October 2023

The article deals with the campaign before the Czech parliamentary elections in 2002, focusing on the imagery concerning the European Union and the expected Czech membership. It explains the radicalizing domestic and international political context, demonstrating that while the EU accession was omnipresent in the campaign, it was reduced to two topics unrelated to the actual entry into the Union, namely Temelín power plant and so called Beneš decrees. The concluding part seeks to relate the institutional aspect of the development to the debate on Europeanization.
The European Union in the Russian State Duma Debates, 1994–2004
Authors: Sablin Ivan
Published: October 2023

Although the European Union (EU) was occasionally presented in a positive light in the lower house of the Russian parliament (the State Duma) in 1994–2004, there were also numerous criticisms of the EU and the “European community” in a broader sense. The discussions were accompanied by vocally articulated anxieties by those factions that were oppositional to the President and the Government but had a strong foothold in the parliament, such as the conservative Communist Party of the Russian Federation (KPRF), the rightwing populist Liberal Democratic Party of Russia (LDPR), and the rightwing Rodina (“Motherland”) Party and its predecessors. These anxieties pertained to Chechnya, Yugoslavia, Ukraine, and the Baltic states as the spaces of contestation between Russia and the EU. The projects of (re)building the Russian (Soviet) imperial formation on the basis of the Commonwealth of Independent States (CIS) or the Union State (of Russia and Belarus) were presented as alternatives to Western European integration based on the EU and the North Atlantic Treaty Organization (NATO). The anti-EU rhetoric in the Duma, which came hand in hand with the denunciation of NATO, provided a discursive foundation for the eventual shift of the President’s and the Government’spolicy. The members of United Russia, the Government’s party without a clear ideology that won a constitutional majority in 2003, adopted elements of conservative and rightwing rhetoric of the formal opposition in 2004. This happened in the context of the EU enlargement when the issues of the accessibility of the Kaliningrad Region and the rights of the Russian speakers in Latvia and Estonia were discussed in the parliament. Later the same year, the start of the Orange Revolution in Ukraine became a further impetus for the Duma’s anti-EU discourse, a discourse that would soon become mainstream in Russian politics.
Enakost v različnem: dejstva in spoznanja o politični problematiki dveh jugoslovanskih držav
Authors: Čepič Zdenko
Published: October 2023

V zgodovini Slovencev se Jugoslaviji ni mogoče izogniti, saj je z njo povezana tudi zgodovina slovenske državnosti oziroma nastajanja slovenske države, prav tako osamosvojitev Slovenije in nastanek neodvisne in suverene slovenske države. To sodi v našo zgodovino, prav tako kot vanjo sodijo življenje Slovencev pod Habsburžani in vse, kar se je zgodilo na našem ozemlju in je vplivalo na takratno življenje tukajšnjega prebivalstva, razvoj Slovencev kot naroda in Slovenije kot države. Zgodovina je nekaj celovitega in ne nekaj, kar nekomu danes ni všeč, kar je treba iz nje izpustiti, spregledati ali pa prikazati kot nekaj skrajno negativnega. To vsaj pri določenih političnih subjektih sedaj velja za Jugoslavijo. Zgodovino želijo prilagoditi svojim političnim pogledom in potrebam. Zgodovinopisje se temu ne sme ukloniti in Jugoslavija, prva in druga, morata imeti v slovenski zgodovini svoj prostor. Podoba prve in druge Jugoslavije je v zgodovini slovenskega naroda lahko le takšna, kot jo izriše znanstveno zgodovinopisje. Obdobje življenja v Jugoslaviji je del slovenske zgodovine in ga je treba kot takšno tudi zgodovinopisno obravnavati.
Influencia de la concepción curricular y su diseño en el aprendizaje de los niños de la educación infantil
Authors: Hernández Jara Peggy Verónica , Andaluz Zúñiga Juana Victoria , Camacho Abril Patricia Elizabeth
Published: October 2023

En el presente artículo se analiza la teoría curricular, se definen y conceptualizan los términos currículo, diseño curricular y los modelos. Se valora la influencia de la concepción curricular y su diseño en el aprendizaje de los niños de la educación infantil; donde se concibe el juego, como principal estrategia en el proceso de enseñanza-aprendizaje. Se aluden los tres ejes de desarrollo y aprendizaje para toda la educación inicial, cada uno de ellos engloba a diferentes ámbitos propuestos para cada subnivel educativo; todo ello facilita la adecuada articulación entre educación inicial y primer grado de educación general básica. En el proceso de constatación se pudo comprobar el incremento del interés y la motivación, en tanto los niños acometieron con gran entusiasmo todas las tareas asignadas durante el desarrollo del curso, lo que facilitó el aprendizaje de las destrezas previstas en cada subnivel educativo.
Estrategia neurodidáctica para el desarrollo de habilidades lectoras en estudiantes de tercer año de Educación General Básica
Authors: Mallitasig Unapanta Amparo del Pilar , Solórzano Sánchez Rossana Paola , Bernal Cerza Raisa Emilia
Published: October 2023

La promoción del desarrollo de habilidades lectoras en estudiantes de tercer año de Educación General Básica es de vital relevancia para su formación académica y desarrollo cognitivo. El presente estudio tuvo como objetivo diseñar una estrategia neurodidáctica destinada a mejorar las habilidades lectoras de los estudiantes en la Escuela América y España. La muestra consistió en 33 estudiantes de tercer año de EGB y 10 docentes de la misma institución. Se emplearon métodos y técnicas de investigación que incluyeron encuestas a estudiantes, entrevistas a docentes, revisión de documentos escolares, currículos y materiales didácticos, así como la validación de la estrategia por un panel de expertos en neurodidáctica, pedagogía y literatura infantil. Los resultados revelaron la existencia de desafíos significativos en el desarrollo de habilidades lectoras entre los estudiantes, incluyendo dificultades en comprensión, velocidad de lectura y motivación. Las preferencias de lectura se inclinaron hacia cuentos y narrativa, y se identificaron necesidades de capacitación docente y acceso a recursos adecuados. La estrategia neurodidáctica diseñada incorporó principios de diversidad lingüística y cultural, promoción de la comunicación oral efectiva, lectura autónoma, desarrollo de habilidades de pensamiento, uso de recursos tecnológicos y biblioteca de aula, entre otros. La evaluación de expertos destacó la relevancia de los objetivos y la idoneidad de los materiales didácticos. Este estudio arroja luz sobre la importancia de abordar los desafíos en la enseñanza de la lectura y ofrece una estrategia integral respaldada por la neurodidáctica para mejorar las habilidades lectoras en los estudiantes de tercer año de EGB.
IMPLEMENTASI KEBIJAKAN PENGELOLAAN SAMPAH
Authors: Mahin Mikael
Published: October 2023

Penelitian Ini Mengkaji Tentang Tentang Implementasi Kebijakan Pengelolaan SampahPada Dinas Lingkungan Hidup Kabupaten Melawi. Teknik pengumpulan data yang digunakan dalampenelitian ini adalah teknik wawancara, teknik observasi, dan dokumentasi. Hasil penelitian inimenunjukkan bahwa Implementasi Kebijakan Pengelolaan Sampah Pada Dinas Lingkungan HidupKabupaten Melawi telah dilaksanakan dengan baik. informasi yang telah disampaikan PemerintahKabupaten Melawi dapat dengan mudah ditangkap atau dicerna secara jelas oleh masyarakat. SumberDaya Implementasi Kebijakan Pengelolaan Sampah Pada Dinas Lingkungan Hidup Kabupaten Melawisudah berjalan sesuai yang diharapkan oleh Pemerintah Kabupaten Melawi dengan jumlah 115 orangmendapatkan gaji sebesar Rp.1.376.817/Bulan dengan status status honorium. Struktur Birokrasi dalamPengelolaan Sampah telah memiliki Standar Operasional Prosedur dalam melaksanakan tugas. Standaroperasional prosedur dibentuk dalam rangka mempelancar proses jalannya implementasi kebijakantentang Pengelolaan Sampah di wilayah Kabupaten Melawi. Menyarankan hendaknya komunikasiyang baik dalam pengelolaan sampah dapat dipertahankan pada masa yang akan datang. Perlu adapeningkatan gaji bagi petugas pengelolaan sampah di Kabupaten Melawi. Struktur Birokrasi perlunyamenjalankan standar operasioanal prosedur yang lebih komprehensif dalam implementasi pengelolaansampah.
UPAYA PENGEMBANGAN USAHA PEMBUATAN TEMPE PADA PABRIK TEMPE NTT KECAMATAN SINTANG
Authors: Darmansah Darmansah
Published: October 2023

Pabrik Tempe NTT Salah satu Industri pengolahan tempe di Kecamatan Sintang yangberdiri sejak tanggal 23 Pebruari 2008, berlokasi di Jalan Jalan Teuku Umar Rt 03/Rw. 02 KelurahanLadang Kecamatan Sintang memiliki 6 orang karyawan. Ditinjau dari aspek pemasarannya hingga saatini usaha pengrajin tempe NTT di Kecamatan Sintang ini membuat dan menyebarluaskan produk tempeselain dipasarkan di kota Sintang juga dikirimkan tersebar ke daerah-daerah kecamatan lainnya diKabupaten Sintang. Seiring dengan berjalannya waktu, pembuatan tempe semakin berkembang hinggatahun 2019, Namun pada tahun 2020 volume penjualannya terjadinya penurunan yang disebabkanoleh situasi ekonomi masyarakat yang semakin lesupada saat pandemic covid19. Pabrik Tempe NTTdidalam memulai kegiatan usahanya hingga saat ini hanya menggunakan modal dari pemilik usaha yangdisebabkan pemilik usaha tidak ingin menanggung beban bunga dari pinjaman usaha dan hanya inginmemaksimalkan dari potensi yang dapat dilakukan oleh kegiatan usahanya. Sumber Daya Manusiapada Pabrik Tempe NTT berjumlah 6 orang maksimal berpendidikan SLTA dilatih secara internperusahaan untuk mengisi berbagai bidang usaha di pabrik dengan menggunakan sistem rolling. Untukkegiatan promosi produk hasil usaha Pabrik Tempe NTT dilakukan dengan cara pemotongan hargaproduk terutama kepada para pelanggan dan konsumen yang membeli produk dalam jumlah yangbesar dan promosi melalui berbagai pamflet, Media internet seperti Watshap, Fb dll serta mengutamakanpelayanan yang baik. Sedangkan pada sektor sarana dan prasarana pada Pabrik Tempe NTT KecamatanSintang memiliki pabrik sendiri dan 3 buah mesin tempe sebagai modal utama pengolahan tempe hinggasaat ini serta 1 kendaraan roda dua dan 1 kendaraan roda empat. Pabrik Tempe NTT KecamatanSintang didalam melakukan kegiatan usahanya dibiayai secara pribadi pemilik usaha, manajemennyamasih bersifat semi tradisional serta tergolong usaha mikro dengan pengembangannya secara bertahap.Sebaiknya pengelolaan kegiatan usaha pada Pabrik Tempe NTT Kecamatan Sintang dilakukanperubahan sesuai dengan kaidah-kaidah pengelolaan yang ada pada fungsi-fungsi manajemen.
More than one landslide per road kilometer – surveying and modeling mass movements along the Rishikesh-Joshimath (NH-7) highway, Uttarakhand, India
Authors: Mey Jürgen , Kumar Guntu Ravi , Plakias Alexander , Silva de Almeida Igo , Schwanghart Wolfgang
Published: October 2023

Abstract. The rapidly expanding Himalayan road network connects rural mountainous regions. However, the fragility of the landscape and poor road construction practices lead to frequent mass movements along-side roads. In this study, we investigate fully or partially road-blocking landslides along the National Highway (NH-7) in Uttarakhand, India, between Rishikesh and Joshimath. Based on an inventory of >300 landslides along the ~250 km long corridor following exceptionally high rainfall during September and October, 2022, we identify the main controls on the spatial occurrence of mass-movement events. Our analysis and modeling approach conceptualizes landslides as a network-attached spatial point pattern. We evaluate different gridded rainfall products and infer the controls on landslide occurrence using Bayesian analysis of an inhomogeneous Poisson process model. Our results reveal that slope, rainfall amounts, lithology and road widening are the main controls on landslide occurrence. The individual effects of aggregated lithozones are consistent with previous assessments of landslide susceptibilities of rock types in the Himalayas. Our model spatially predicts landslide occurrences and can be adapted for other rainfall scenarios, and thus has potential applications for efficiently allocating efforts for road maintenance. To this end, our results highlight the vulnerability of the Himalayan road network to landslides. Climate change and increasing exposure along this pilgrimage route will likely exacerbate landslide risk along the NH-7 in the future.
Air pollution walk as an impact education tool for air quality sensitization in the global south
Authors: Bej Debabrata , Ghosh Sandip Sankar , Haldar Srijan , Roy Arindam
Published: October 2023

Abstract. Air pollution has become a serious matter of concern in the global south and a significant amount of funding has been used to create awareness of air pollution. The conventional method of sensitization relies on workshops where slide-based presentations, images, plots and graphs are shown to the participants. However, sensitization about air quality using such an audio-visual format might not be sufficient to create adequate impact. Here in this study, we propose a new sensitization technique, the pollution walk, where participants and a subject matter expert will walk through different urban micro-environments with live air quality monitor. A pilot involving three such pollution walks with 24 participants were conducted in a south Asian megacity and pre and post-ante survey were conducted. The results indicate a greater sense of understanding among the participants and multidisciplinary nature of the air pollution problem has been well communicated. To understand the long-term impact, a survey after one year has been done which clearly indicates high levels of awareness and behavioural changes among the participants.
Brief communication: On the environmental impacts of 2023 flood in Emilia-Romagna (Italy)
Authors: Arrighi Chiara , Domeneghetti Alessio
Published: October 2023

Abstract. The impacts of floods to environmental assets are often not assessed. This communication reflects on this issue by analysing the reported environmental consequences of the 2023 Emilia-Romagna flood. The information on the environmental impacts is constructed by collecting data from reports, press releases and interviews in the aftermath of the event. The most frequently reported damages involve water resources and water-related ecosystems, with cultural and supporting ecosystem services particularly affected. Indirect effects in time and space, intrinsic recovery capacity, cascade impacts on socio-economic systems and lack of established monitoring activities appear as the most challenging aspects for future research.
Forced-motion simulations of vortex-induced vibrations of wind turbine blades – a study of sensitivities
Authors: Grinderslev Christian , Houtin-Mongrolle Felix , Nørmark Sørensen Niels , Raimund Pirrung Georg , Jacobs Pim , Ahmed Aqeel , Duboc Bastien
Published: October 2023

Abstract. Vortex-induced vibrations on wind turbine blades are a complex phenomenon not predictable by standard engineering models. For this reason, higher-fidelity computational fluid dynamics (CFD) methods are needed. However, the term CFD covers a broad range of fidelities, and this study investigates which choices have to be made when wanting to capture the vortex-induced vibration (VIV) phenomenon to a satisfying degree. The method studied is the so-called forced-motion (FM) approach, where the structural motion is imposed on the CFD blade surface through mode shape assumptions rather than fully coupled two-way fluid–structure interaction. In the study, two independent CFD solvers, EllipSys3D and Ansys CFX, are used and five different turbulence models of varying fidelities are tested. Varying flow scenarios are studied with low to high inclination angles, which determine the component of the flow in the spanwise direction. In all scenarios, the cross-sectional component of the flow is close to perpendicular to the chord of the blade. It is found that the low-inclination-angle and high-inclination-angle scenarios, despite having a difference equivalent to up to only a 30∘ azimuth, have quite different requirements of both grid resolution and turbulence models. For high inclination angles, where the flow has a large spanwise component from the tip towards the root, satisfying results are found from quite affordable grid sizes, and even with unsteady Reynolds-averaged Navier–Stokes (URANS) k–ω turbulence, the result is quite consistent with models resolving more of the turbulent scales. For low inclination, which has a high degree of natural vortex shedding, the picture is the opposite. Here, even for scale-resolving turbulence models, a much finer grid resolution is needed. This allows us to capture the many incoherent vortices, which have a large impact on the coherent vortices, which in turn inject power into the blade or extract power. It is found that a good consistency is seen using different variations of the higher-fidelity hybrid RANS–large eddy simulation (LES) turbulence models, like improved delayed detached eddy simulation (IDDES), stress-blended eddy simulation (SBES) and k–ω scale-adaptive simulation (SAS) models, which agree well for various flow conditions and imposed amplitudes. This study shows that extensive care and consideration are needed when modeling 3D VIVs using CFD, as the flow phenomena, and thereby solver requirements, rapidly change for different scenarios.
Weight Reducing Effect of Moringa Oleifera Leaves Against Induced Obesity in Rabbits
Authors: Khalid Syed Saqib , Zehra Tabassum , Ali Fizzah , Batool Fizza
Published: October 2023

Objectives: To study the weight-reducing effect of M. Oleifera Leaves against induced obesity in rabbits. Study Design and Settings: It was an animal study conducted in the Department of Pharmacology, Liaquat National Hospital & Medical College, Karachi. Methodology: The study period was 6 months, and random sampling was done. Twenty four Healthy rabbits of either sex, weighing 1–2 kg and aged 1-3 years, were included in the study. Sick rabbits weighing less than 1 kg or more than 2 kg and aged less than 1 year or more than 3 years were excluded from the study. Results: The weight of Group B animals fed with a high-fat diet (HFD) for 28 days increased significantly from 1.28±0.07 to 1.88 ± 0.17. While the weight of Group C and D rabbits which were fed with M. oleifera extract(300mg/kg and 600mg/kg) along with a HFD for 28 days, increased slightly from 1.38±0.07 to 1.53± 0.08 and from 1.25±0.13 to 1.38± 0.14 respectively. P-value of weight on Day 28 also became significant with a P-value of (0.000), which was (0.176) on Day 0, proving the anti-obesity effects of M. oleifera leaves. Conclusion: In our study, we found out that there was a significant weight-reducing effect of M. oleifera leaves against obesity induced rabbits as well as skin fold thickness was also decreased. This study also indicates that the given dose of M. oleifera leaves extracts are devoid of any side effects
Impact of Maternal Body Mass Index (BMI) and Age on Pregnancy Outcomes at a Tertiary Care Hospital
Authors:   Armed Forces Post Graduate Medical Institute, Rawalpindi, Iffet Shazia , Arif Ayesha , Moin Sadaf , Raja Aisha , Arif Sadia , Arif Nadia
Published: October 2023

Objectives: To analyze the role of maternal BMI and age on pregnancy outcomes. Study design and Setting: A retrospective cohort study CMH, Abbottabad from 1st August 2022 to 31st January 2023 Methodology:A retrospective cohort study was done over a period of 6 months in 500 post-natal women whose BMI were calculated and recorded at first trimester during their booking visit and eventually delivered at combined military hospital, Abbottabad. Data related to age, BMI, gestational age at the time of delivery, spontaneous or induction of labour and mode of delivery were evaluated. Results: The study included 500 female patients. The mean age and BMI were 32±11.5 years and 28.8±8 respectively. 140 (28%) females had normal weight, 310(62%) and 50(10%) were overweight and obese respectively. The variable age at the time of booking was divided into three groups = 20 years, 21-35 years, and 36-42 years which included 80(16.4%), 275(55%) and 145(29%) patients respectively. Multigravida were 285(57%) and prim gravida were 215(43%). Induction was given to 275(55%) and those who went into spontaneous labour were 225(45%). Delivery at term that is = 37 weeks was 455(91%) and only 45(9%) were delivered before 37 weeks. Percentage of women having a spontaneous vaginal delivery was 230(46%) and 250(50%) had LSCS and 20(4%) underwent instrumental delivery. Conclusion: It was evident that raised BMI and maternal age had confounding effects on pregnancy outcomes. The incidence of LSCS was more in patients with higher BMI and age.
The Dynamic Competition Paradigm: Insights and Implications
Authors: Teece David J.
Published: October 2023

See article page for abstract text.
Rethinking Community Reinvestment
Authors: Della Rocca Benjamin
Published: October 2023

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Usnea jingdongensis sp. nov. from Southwest China
Authors: Chen Yu-Xin , Wang Li-Bao , Xie Yu-Huan , Guo Shou-Yu , Han Liu-Fu
Published: October 2023

Usnea jingdongensis from the Ailaoshan Mountain of Southwest China, is described as a new species of Parmeliaceae. It is characterized by the uninflated branches, fistulose axis with pale brown to dark brown loose hyphae, and the absence of pseudocyphellae and soralia.
The phylogenetic analysis of the nrDNA ITS sequence data supported the recognition of the species. A key to the eumitrioid Usnea species in China is also provided.
#MassTestingNowPH tweets as acts of citizenship: The rhetorical functions of tweets in pandemic-stricken Philippines
Authors: Ladia Charles Erize P.
Published: October 2023

Constrained physical mobility and oppositional action during the COVID-19 pandemic in the Philippines drove many Filipinos to turn to social media affordances, like Twitter’s hashtags, as sites of free speech, dissent, and collective action. One of which, #MassTestingNowPH, called for the implementation of mass testing for the vulnerable population and objected to Rodrigo Duterte’s militaristic pandemic response. This paper examined how #MassTestingNowPH tweets served as acts of citizenship and exerted their rhetorical functions in the digital space during this global medical crisis. Using rhetorical political analysis, this research found that #MassTestingNowPH tweets manifested acts of citizenship by asserting citizens’ rights and responsibilities, and exacting government’s accountability in newly-formed ad hoc publics. Users criticized the country’s COVID-19 response and the injustices of VIP testing for some of its officials. These criticisms enabled them to generate collective grievances for medical frontliners and the marginalized. With these sentiments, netizens called on their audiences to act on their judgment and assert their citizenship in online and offline platforms. These tweets, as acts of citizenship, performed three rhetorical functions: forensic, epideictic, and deliberative. This rhetorical process shaped Twitter’s hashtag as an ad hoc public and the meaning of citizenship in our highly-networked world.
Method development and validation of a new stability indicating HPLC and LC-APCI-MS methods for the determination of Bumetanide
Authors: Chandrakant Kulkarni Dipak , Sunil Dadhich Anima , Mathrusri Annapurna Mukthinuthalapati
Published: October 2023

Bumetanide is a diuretic used to reduce edema caused by the conditions such as heart failure, kidney disease, and liver disease. A new stability indicating isocratic LC-APCI-MS and RP-HPLC methods have been developed and validated for the estimation of Bumetanide as per ICH guidelines. Thermo scientific-TSQ Quantis with Vanquish HPLC coupled with MS was used for the present study. Simpack C18 column was used for chromatographic resolution and a triple quadrupole mass spectrometer with atmospheric pressure chemical ionization (APCI) source, running in the positive mode (as well as negative mode) was used for detection. A mixture of 0.1% Formic acid: Acetonitrile was used as mobile phase on gradient mode and Acetonitrile was used as diluent. A wide linearity concentration range 5.0-200 μg/ml was shown by the proposed method. The proposed methods are simple, precise, accurate and used to quantify the marketed formulations of Bumetanide. Stress degradation studies were performed and the method is found to be selective and specific.
Synthesis, Characterization and Biological Evaluation of some new Isoxazole and Pyrazole compounds for Anti-obesity drug
Authors: Agrawal Bhagyashree , Kumar Gupta Bhaskar , Kumar Sahu Satish
Published: October 2023

The discipline of medicinal chemistry is dedicated to the discovery and development of new agents for treating diseases. Most of this activity directed to new natural or synthetic organic compounds. Development of organic compounds has grown beyond traditional synthetic methods. It now includes the new exciting new field of biotechnology using cells biochemistry to synthesize new compounds. Chemical synthesis is purposeful execution of chemical reactions to get a product or several products. Chemical synthesis is purposeful execution of chemical reactions to get a product or several products. The requirement is to synthesize novel molecules having good potential with high therapeutic index. Keeping in view the diverse therapeutic activities of Chalcones for the preparation of bioactive heterocycles, it was contemplated to synthesize a novel series of Chalcones. Attention has been focused on the substitution of acetophenone and benzaldehydes to achieve new anti-obesity profiles.
A Systematic Review on Chemical Composition and Biological Activities of cedar Oils and Extracts
Authors: Chauiyakh Oussama , El Fahime Elmostafa , Aarabi Samar , Ninich Oumaima , Bentata Fatiha , Kettani Kamal , Chaouch Abdelaziz , Ettahir Aziz
Published: October 2023

The valorization of aromatic and medicinal plants is a vital research axis in the field of valorization and optimization of natural resources. Cedar is one of the most sought-after plants in the world due to the quality of its wood and its richness in bioactive molecules that can be used in the pharmaceutical, cosmetic, and perfumery industries. Using keywords such as: Cedrusatlantica Manetti, Cedrusbrevifolia Henry, Cedrus deodara London,Cedruslibani London and Cedrusbrevifolia Henry, articles were collected from international scientific databases. The analysis of the abstracts of these articles by computer tools such as Zotero, Excel, and Nvivo allowed us to conclude that the chemical composition of cedar varies from one species to another and from one part of the plant to another and according to the harvesting environment. However, it is generally characterized by the dominance of terpenes. The latter is known to have antimicrobial properties, which explains the effectiveness of the oils and extracts of this plant against fungi and bacteria such as helicobacter pylori, Gram-positive and Gram-negative bacteria, and important anticancer power.
LOCAL CHURCHES OWNED BUSINESS AS STRATEGIC TOWARD SUSTAINABILTY AND FINANCIAL OTONOMY
Authors: Darnita Cristi Devi
Published: October 2023

The purpose of this paper is to describe and analyze the strategy of local churches, in this case, tribal churches that exist in GKE Resort Tewah, for sustainability and financial independence by building businesses owned by the church. The method used is exploratory qualitative with observation, interview, and documentation study techniques. This paper concluded that the church, as a non-profit organization, can build a business to support church finances. Local churches build businesses as one of the church's financial management strategies sourced from the empowerment of church assets. Empowerment of local church assets is classified as a business in the form of investment in property assets included in non-current assets. Income from church-owned businesses is recognized and recorded as general church income so that the income is used to fund church operations. Business ownership by local churches today can be one of the strategies to achieve the financial independence of the church and the sustainability of local churches that depend on the offerings given by the congregation.
Corrosion behavior of TiN and TiCN coatings synthesized by PVD on the spark plasma sintered NiTi substrate
Authors: Botshekanan Nasim , Majidian Hudsa , Farvizi Mohammad
Published: October 2023

TiN and TiCN coatings have garnered widespread attentions in the field of materials science and engineering because of their exceptional characteristics, including high melting point, excellent thermal conductivity, remarkable chemical stability, superior corrosion and wear resistance, and notable biocompatibility. These properties make them highly suitable for coating various alloys, and as a result, they have been successfully applied in numerous applications. The aim of this research study is to delve into the corrosion behavior of spark plasma sintered NiTi substrates that were coated with TiN and TiCN employing physical vapor deposition (cathodic arc technology). In order to comprehensively analyze the corrosion response, potentiodynamic polarization and electrochemical impedance spectroscopy techniques were employed. To gain deeper insights into the impact of the coating, a meticulous comparison was conducted between the corrosion resistance of the uncoated specimen and that of the coated ones. The results showcased a significant enhancement in corrosion resistance for both coated samples when compared to the uncoated NiTi substrate. However, it was found that the TiN-coated specimen showed even higher corrosion resistance than the TiCN-coated counterpart. These findings highlight the superiority of TiN coatings in terms of corrosion resistance when applied on the NiTi substrate.
Penegakan Diagnosis dan Penatalaksanaan Herpes Zoster
Authors: Devi Maria , Ismunandar Helmi , Wintoko Risal , Hadibrata Exsa , Djausal Anisa Nuraisa
Published: October 2023

Herpes zoster merupakan penyakit neurokutaneus yang disebabkan karena varicella-zoster virus (VZV). Paparan primer dari virus varicella-zoster akan bermanifestasi sebagai varicella atau chickenpox dan mengalami reaktivasi menyebabkan shingles atau dikenal dengan herpes zoster. Transmisi dari herpes zoster melalui rute respirasi dan menginfeksi sel epitel pada traktus pernapasan atas. Risiko tertular herpes zoster diperkirakan sekitar 15-30%, akan tetapi risikonya lebih tinggi pada orang dewasa dan usia lanjut, pasien dengan immunocompromised, dan pasien yang memiliki komorbiditas. Puncak insiden herpes zoster di Indonesia terjadi pada kisaran usia 45-64 tahun. Infeksi herpes zoster biasanya diawali dengan gejala prodromal seperti malaise, sakit kepala, demam, myalgia lokal, arthralgia, pruritus (sensasi gatal), dan parestesia (kesemutan) sepanjang dermatom yang mendahului ruam dalam beberapa jam hingga beberapa hari. Penyakit herpes zoster dapat menurunkan efektivitas dan kualitas hidup pasien akibat rasa nyeri hebat yang ditimbulkan saat fase prodromal, dan setelah lesi sembuh dapat menyebabkan postherpetic neuralgia (PHN). Pentingnya penegakan diagnosis awal disertai dengan penanganan efektif berfungsi untuk menangani kondisi akut, menghambat berkembangnya penyakit, menurunkan rasa nyeri akibat lesi pada kulit, dan mencegah komplikasi akibat kondisi kronis. Diagnosis herpes zoster akan sangat jelas, karena gambaran klinisnya khas. Herpes zoster umumnya didiagnosis secara klinis setelah munculnya ruam. Tetapi, sebelum ruam timbul dan pada kasus atipikal, diagnosis mungkin memerlukan konfirmasi laboratorium. Artikel ini akan membahas informasi mengenai etiologi, patofisiologi, penegakan diagnosis, serta penatalaksanaan yang dapat dilakukan pada kasus herpes zoster.
ROLE OF OBESITY IN BREAST CANCER METASTASIS
Authors: Daraz Fadila Gustiani , Windarti Indri , Ayu Sangging Putu Ristyaning
Published: October 2023

Kanker payudara adalah jenis kanker yang paling umum diderita wanita di seluruh dunia. Salah satu faktor yang diyakini memiliki peran dalam perkembangan dan pertumbuhan kanker payudara adalah status gizi yang dapat dihubungkan dengan indeks massa tubuh pasien dewasa. Diperkirakan bahwa berat badan berlebih dan obesitas menjadi salah satu faktor risiko penyebaran kanker payudara menjadi metastasis jauh. Mekanisme penyebaran melalui dua cara, estrogen dan leptin. Aromatase adalah enzim dalam biosintesis estrogen yang mendorong pertumbuhan tumor melalui ekspresinya dalam sel stroma adiposa payudara. Sedangkan, leptin dihasilkan oleh adiposit. Adiposit yang mengalami hipertrofi dan hiperplasia menyebabkan perubahan patofisiologi yang berpengaruh pada perkembangan kanker payudara. Berbagai studi kasus menunjukkan diet tinggi lemak dan kalori berkaitan dengan timbulnya kanker payudara.  Tingginya risiko obesitas terhadap metastasis kanker payudara. ini penting untuk dikaji lebih lanjut karena banyaknya kasus kanker payudara baik secara global, di Indonesia maupun di Lampung. Artikel review ini penting untuk mengetahui hubungan obesitas dengan metastasis kanker payudara, sebagai informasi ilmiah dan pengetahuan, serta dapat dijadikan bahan intervensi diet pada pasien kanker payudara yang mengalami obesitas.
Obesity in Children : Long-Term Causes and Consequences
Authors: Fitriliani Ananda , Pramesona Bayu Anggileo , Nareswari Shinta
Published: October 2023

Obesity in children has reached epidemic levels in both developed and developing countries. Overweight and obesity in childhood are known to have a significant impact on physical and psychological health. Overweight and obese children tend to be obese into adulthood and are more likely to develop non-communicable diseases such as diabetes and cardiovascular disease at a younger age. The mechanism of obesity is not fully understood and is believed to be a disorder with various causes. In general, overweight and obesity are assumed to result from increased calorie and fat intake. On the other hand, there is supporting evidence that excessive sugar intake through soft drinks, an increase in portion size, and a steady decline in physical activity play a major role in the increase in obesity rates worldwide. Child obesity can greatly affect children's physical, social and emotional well-being, and self-confidence. It is also associated with poor academic performance and a lower quality of life experienced by children. Many comorbid conditions such as metabolic, cardiovascular, orthopedic, neurological, hepatic, pulmonary, and renal disorders have also been seen to be associated with childhood obesity. The growing problem of childhood obesity can be slowed, if society focuses on its causes. Overweight and obesity cannot be solved through individual actions alone. A comprehensive response is needed to create a healthy environment that can support individuals in making healthy choices based on knowledge and skills related to health and nutrition. This response requires government commitment and leadership, long-term investment, and whole-of-society engagement to protect children's right to good health and well-being. Progress can be made if all actors remain committed to working together towards the common goal of ending childhood obesity. This literature review discusses obesity in children by explaining what risk factors influence and long-term consequences for children.
Nahit Sırrı Örik’in Gezi Yazılarında Modernleşen Anadolu Kentleri
Authors: OKTAY Neşe
Published: October 2023

Nahit Sırrı Örik, Cumhuriyet döneminin hikâye, roman, deneme, gezi yazısı gibi farklı nesir türlerinde eser vermiş; ancak edebî seçimlerinden kaynaklı olarak devrinde ve edebiyat tarihi içerisinde uzun yıllar boyunca unutulmuş bir yazardır. Bu unutuşta memleket için edebiyatın yapıldığı devrede, geçmişten kalan dil ve konuları tercih etmesi etkili olarak görülmüştür. Ankara/Anadolu edebiyatına karşılık İstanbul edebiyatını seçtiği düşünüldüğü için unutulmasına rağmen Nahit Sırrı gezi yazılarında uzun zaman gezdiği, yaşadığı Avrupa kentlerini değil, romanlarında da kimi zaman mekân olarak kullandığı Anadolu kentlerini anlatmıştır. Seyahat edebiyatı yazıldığı devrenin siyasi bakış açısıyla yakın temaslar içerisindedir. Gezi yazılarının yazılması veya yazılamaması, gezmek ve yazmak için seçilen yerler, bu mekânlarda dikkat edilen hususlar gibi birçok unsur siyasi konjonktürün etkisindedir. Nahit Sırrı’nın gezi yazıları Erken Cumhuriyet adı verilen devrede kaleme alınmış olması ve Cumhuriyet’in ideolojisinden izler taşıması bakımından önemlidir. Cumhuriyet, ideolojisini ve varlığını mekân üzerinden kurgularken Ankara başta olmak üzere şehirlerin modernleşmesi için demiryolları, sanayi, mimari, turizm gibi çeşitli göstergelerin üzerinde durmuştur. Bu yazıda sözü edilen bağlam etrafında Nahit Sırrı’nın yazıları değerlendirilerek Cumhuriyet’in şehirlere yaklaşımı devrin içinden bir bakışla ortaya konarak hem devrin edebiyatı şekillendirmesi hem edebiyatın devre etkileri bir arada değerlendirilmeye çalışılacaktır.
Halkevlerinin Yayın Faaliyetleri: Van Tarihine Medhal Birinci Sardur’un Kitabeleri Örneği
Authors: ŞAHİN Güneş , DEMİREL Şengül
Published: October 2023

Çalışmadaki amaç, ülke çapında 1932’de açılan halkevlerinin yayın faaliyetleri üzerinden, Van Halkevi’nin tek yayını olarak tespit edebildiğimiz, halk dershaneleri komitesi başkanı ve aynı zamanda Maarif Müdürü olan Mustafa Noyan tarafından kaleme alınan Van Tarihine Medhal Birinci Sardur’un Kitabeleri isimli eserini analiz etmek ve erken dönem Cumhuriyet arkeolojisine katkılarını değerlendirmektir. Halkevleri açıldıktan sonra fiziki şartları el verdiği müddetçe şube kolları ile çalışmalar yürütmüştür. Dil-edebiyat ve tarih şubesi ile kitapsaray ve yayın şubesi bünyesinde açıldığı halkevinde yayın faaliyetlerinden sorumlu olmuştur. Kemalist ideolojinin halk nezdinde yayılması ve devrim mantığının anlaşılması için halkevleri yayınladıkları gazete, dergi, kitap, broşürlerle kendi etkinlik alanlarını yaratmışlardır. Özellikle cumhuriyet rejiminin idealize ettiği aynı ülkü etrafında toplanmış ve kaynaşmış bir toplum oluşturulması noktasında çalışmalar yürüten şubeler tarih, edebiyat, folklor, halk bilimi konularında eserler ortaya çıkarmıştır. Söz konusu eserlerde temel prensip millî değerlerin ve kültürün genç nesillere öğretilmesidir. Bu süreç de şüphesiz, okuma-yazma etkinliği ile anlaşılabilecek ve aktarılacaktır. Çalışmada, ülke genelindeki halkevlerinin yayın faaliyetleri ile ne amaçladığını izah etmeye çalışmakla birlikte, 1940’lı yılların başında Van Kalesi/Urartular ile ilgili yüksek bir bilinç seviyesine ve çalışma azmine sahip Mustafa Noyan’ın söz konusu eserini akademik olarak incelemek hedeflenmektedir.
Development and validation of competency framework for pharmacy undergraduate programs in Brazil
Authors: Brito Aline de Sousa , Garcia Telma Alves , Lopes Flavio Marques
Published: October 2023

Pharmaceutical education in Brazil undergoes structuring in the requirement to train professionals working in health care, providing pharmaceutical services, in contact with the patient and the community. To meet this new demand for education, an expansion of higher education arises that increasingly requires the presence of qualified teachers and in a constant process of updating. Competency-based teaching is the strategy applied to meet this demand, based on a document that gathers information on the main guiding competencies in pharmaceutical training. In view of this, the aim of this study was to develop and validate a competency matrix for pharmacy courses. For that a qualitative study was carried out with interviews seeking the opinion and experiences of teachers who work in pharmacy courses in the most different areas that generated a preliminary skills matrix, sent for evaluation by teachers in the pharmacy course in several regions of Brazil, using the Delphi method in two rounds, with a five-point Likert scale. 86 competences were obtained grouped in seven thematic domains, observing the teachers' consensus in face of the needs of the knowledge, skills and attitudes that are essential for the training of the pharmacist.
Análisis de los factores que limitan a los pequeños productores en el desarrollo de la actividad cacaotera en México
Authors: Sántiz Russell , Nadal Ana , Salvatierra Benito , Nazar Dominga , Bello Eduardo
Published: October 2023

México es pionero en el cultivo del cacao y el consumo del chocolate por parte de las civilizaciones mokaya, olmeca y maya. A pesar de esto, su aporte en las estadísticas de la producción mundial del cacao mokaya es relativamente baja. Esto se debe a que los productores y el cultivo enfrentan varios factores limitantes que crean las condiciones necesarias para una tendencia a la baja en términos de producción. En este contexto, el objetivo del estudio fue analizar desde una perspectiva multidisciplinaria los factores limitantes que enfrentan los productores de cacao en México, así como sus interacciones durante la producción, transformación y comercialización del cacao en grano y derivados. Para ello se emplearon métodos cualitativos basados en una revisión sistemática de la literatura de investigación científica, en las bases de datos de Web of Science, Scopus y Google Scholar. Se consideraron artículos de investigación, libros y capítulos publicados entre 2005 a 2020 en español e inglés, que abordarán problemáticas de los estados productores (Chiapas, Guerrero, Oaxaca y Tabasco) relacionadas con los productores de cacao, la producción, transformación o comercio del cacao y derivados. Inicialmente se identificaron 438 publicaciones. Después de filtrarlas, empleando los criterios de inclusión, se obtuvo la muestra final de 17 publicaciones. Los resultados mostraron que existen al menos 45 factores limitantes que interactúan con el productor de cacao, los cuales se distribuyen en seis ámbitos diferentes. Se identificó que el ámbito más significativo fue el de “Cultivo y cosecha de cacao” y que los factores “Manejo convencional” y “Enfermedades de las plantaciones” fueron las principales limitantes para el cultivo del cacao en México. Además, se observó que el factor “Organización deficiente” es una limitante que afecta a los productores en todos los ámbitos analizados. Finalmente, los hallazgos de este estudio podrían utilizarse como una herramienta orientadora por la academia e instituciones gubernamentales y no gubernamentales, ya que las áreas críticas y limitaciones del sector están expuestas a lo largo de toda la cadena de valor del cacao, con especial énfasis en los pequeños productores.
Tipificación socioproductiva de los agroecosistemas de producción de cacao de Manabí, Ecuador
Authors: Guillen Saskia , Urdaneta Fátima , Portillo Elvis
Published: October 2023

Ecuador se destaca por ser tradicionalmente el primer productor en grano de cacao fino y de aroma a nivel mundial. Sin embargo, en los sistemas productivos persisten prácticas y características (sociales, técnicas y económicas) que limitan la expresión de su productividad y calidad. Tomando en cuenta la multiplicidad de variables involucradas y la complejidad de las interrelaciones sistémicas de estas formas de producción, se plantearon como objetivos de esta investigación: tipificar los sistemas de producción de cacao de la provincia de Manabí, dado que esta representa la mayor superficie de cacao cultivado en Ecuador (130.945 hectáreas), identificar los factores críticos que determinan esas diferencias entre grupos y analizar su comportamiento productivo. Para ello, se tomó una muestra de 150 productores a quienes se les aplicó un cuestionario. Se calcularon índices adimensionales a los cuales se les aplico análisis clúster. Los grupos se caracterizaron con estadísticas descriptivas y los factores críticos, se identificaron con análisis de varianza o 2 dependiendo del tipo de variable. Los resultados muestran la conformación de 4 grupos con buenos valores para el índice agronómico (0,60), no así para el índice gerencial, cuyos valores no superan 0,50. Los grupos 3 y 4 resaltan por sus índices poscosecha (0,71 y 0,48 respectivamente) y muestran los mayores ingresos por hectárea (393,91 y 317,31 US$/ha), porque reciben mejor precio. Los factores críticos significativos (p ≤ 0,05) resultaron ser el manejo poscosecha, el manejo agronómico (fertilización, poda y riego), los servicios públicos, la asistencia técnica en sus relaciones con el entorno y desde el punto de vista gerencial, el manejo de registros, la mano de obra, la legalización de la tierra y el estar asociado. El análisis de los indicadores productivos por grupo, permitió concluir, que las prácticas poscosecha repercuten en los ingresos de cada productor y será el índice poscosecha, el factor crítico más importante para mejorar la respuesta del sistema.