bluuebunny/crossref_metadata_2025 huggingface dataset:
Defining the Functionally Important Domain and Amino Acid Residues in Mycobacterium tuberculosis Integration Host Factor for Genome Stability, DNA Binding, and Integrative Recombination
Authors: Sharadamma Narayanaswamy , Harshavardhana Yadumurthy , Muniyappa K.
Published: July 2017

The integration host factor of
Mycobacterium tuberculosis
(mIHF) consists of a single polypeptide chain, the product of the
ihf
gene. We previously revealed that mIHF is a novel member of a new class of nucleoid-associated proteins that have important roles in DNA damage response, nucleoid compaction, and integrative recombination. The mIHF contains a region of 86 amino acids at its N terminus, absent from both α- and β-subunits of
Escherichia coli
IHF. However, the functional significance of an extra 86-amino-acid region in the full-length protein remains unknown. Here, we report the structure/function relationship of the DNA-binding and integrative recombination-stimulating activity of mIHF. Deletion mutagenesis showed that an extra 86-amino-acid region at the N terminus is dispensable; the C-terminal region possesses the sequences essential for its known biological functions, including the ability to suppress the sensitivity of
E. coli
Δ
ihfA
and Δ
ihfB
cells to DNA-damaging agents, DNA binding, DNA multimerization-circularization, and stimulation of phage L5 integrase-catalyzed integrative recombination. Single and double alanine substitutions at positions Arg170 and Arg171, located at the mIHF DNA-binding site, abrogated its capacity to suppress the sensitivity of
E. coli ΔihfA
and Δ
ihfB
cells to DNA-damaging agents. The variants encoded by these mutant alleles failed to bind DNA and stimulate integrative recombination. Interestingly, the DNA-binding activity of the mIHF-R173A variant remained largely unaffected; however, it was unable to stimulate integrative recombination, thus revealing a separation-of-function allele of mIHF. The functional and structural characterization of this separation-of-function allele of mIHF could reveal previously unknown functions of IHF.

IMPORTANCE
The integration host factor of
Mycobacterium tuberculosis
is a novel nucleoid-associated protein. mIHF plays a vital role in DNA damage response, nucleoid compaction, and integrative recombination. Intriguingly, mIHF contains an extra 86-amino-acid region at its N terminus, absent from both α- and β-subunits of
Escherichia coli
IHF, whose functional significance is unknown. Furthermore, a triad of arginine residues located at the mIHF-DNA interface have been implicated in a range of its functions. Here, we reveal the roles of N- and C-terminal regions of mIHF and the individual residues in the Arg triad for their ability to provide protection
in vivo
against DNA damage, bind DNA, and stimulate integrase-catalyzed site-specific recombination.
The first pterosaur pelvic material from the Dinosaur Park Formation (Campanian) and implications for azhdarchid locomotion
Authors: Funston Gregory F. , Martin-Silverstone Elizabeth , Currie Philip J.
Published: July 2017

A partial pterosaur pelvis from the Campanian Dinosaur Park Formation of Canada adds to our knowledge of Late Cretaceous pterosaurs. The pelvis is tentatively referred to Azhdarchidae and represents the first pelvic material from a North American azhdarchid. The morphology of the ilium is bizarre compared with other pterosaurs: it is highly pneumatized, the preacetabular process tapers anteriorly, and muscle scars show that it would have anchored strong adductor musculature for the hindlimb. The acetabulum is deep and faces ventrolaterally, allowing the limb to be positioned underneath the body. These features support previous suggestions that azhdarchids were well adapted to terrestrial locomotion.
A Partial Backordering Inventory Model with a Drop-Shipping Option Under Purchase Dependence
Authors: Park Changkyu
Published: July 2017

Drop-shipping is a commonly adopted online-order fulfillment strategy in the Internet age. In this practice, online retailers leverage the fulfillment capabilities of suppliers to fulfill orders. On the other hand, purchase dependence is a frequent phenomenon and is characterized by the purchase of certain items together due to their unknown interior associations. Although this concept has been significantly examined in the marketing field (e.g., market basket analysis), it has largely remained unaddressed in operations management. This paper develops an [Formula: see text] model to address an environment in which unmet demand orders are partially lost and partially backordered when purchase dependence exists. The partial backorders are fulfilled by a drop-shipping option. Through computational analyses, this paper demonstrates the effect of both drop-shipping on a partial backordering and purchase dependence. The results show that more profit can be realized by utilizing a drop-shipping option under purchase dependence.
Resistive Switching Behavior of Au/TiO2/NiCr Structure
Authors: Cristopher M. M. , Dhanisha K. M. , Abinaya M. , Deepak Raj P. , Jeyadheepan K. , Sridharan M.
Published: July 2017

Thin film memristor behavior depends on the choice of top and bottom electrode material and metal oxide layer. In the present work, the influence of the top and bottom electrode layers on the electric field-induced resistance switching phenomena of TiO2-based MIM was studied. Au/TiO2/NiCr and NiCr/TiO2/Au structures were fabricated by depositing TiO2 active layer by reactive dc magnetron sputtering technique between thermally evaporated NiCr and Au electrodes. TiO2 layer was sputtered with a cathode power of 150[Formula: see text]W keeping the other deposition parameters constant. TiO2 films were analyzed by X-ray diffractometer, field emission scanning electron microscopy and UV–Visible spectrophotometer to investigate their structural, morphological and optical behavior. Structural studies of the films reveal that the samples were amorphous. And the [Formula: see text]–[Formula: see text] analysis for the fabricated MIM structure was analyzed.
Nonlinear Optical Behavior of Nanostructured 4-Dimethyl-Aminopyridinium Dihydrogen Phosphate
Authors: Muruganandi G. , Jessie Raj M. B. , Sabari Girisun T. C.
Published: July 2017

Optical nonlinearity of 4-dimethyl aminopyridinium dihydrogen phosphate (DMAPDP) was studied using continuous wave of diode pumped Nd:YAG laser (532[Formula: see text]nm, 50[Formula: see text]mW). The nonlinear refractive index, nonlinear absorption coefficient and nonlinear optical (NLO) susceptibility of the sample were found to be in the order of 10[Formula: see text][Formula: see text]cm2/W, 10[Formula: see text][Formula: see text]cm/W and 10[Formula: see text] esu respectively. The observed self defocusing effect was used to demonstrate the optical limiting action at 532[Formula: see text]nm. Initially, XRD analysis showed that DMAPDP crystallizes in triclinic crystal system with centrosymmetric space group [Formula: see text]. Thermal studies explored that the material undergoes an irreversible endothermic transition at 192[Formula: see text]C which correspond to the decomposition of material. SEM image portrays the formation of nanoparticles with grain size in the range of 45–170[Formula: see text]nm. Hence 4-dimethyl aminopyridinium dihydrogen phosphate nanoparticles can be used as potential candidate for optical limiting applications.
Investigation on V2O5 Thin Films Prepared by Spray Pyrolysis Technique
Authors: Anasthasiya A. Nancy Anna , Gowtham K. , Shruthi R. , Pandeeswari R. , Jeyaprakash B. G.
Published: July 2017

The spray pyrolysis technique was employed to deposit V2O5 thin films on a glass substrate. By varying the precursor solution volume from 10[Formula: see text]mL to 50[Formula: see text]mL in steps of 10[Formula: see text]mL, films of various thicknesses were prepared. Orthorhombic polycrystalline V2O5 films were inferred from the XRD pattern irrespective of precursor solution volume. The micro-Raman studies suggested that annealed V2O5 thin film has good crystallinity. The effect of precursor solution volume on morphological and optical properties were analysed and reported.
Noncoding Centromeric RNA Expression Impairs Chromosome Stability in Human and Murine Stem Cells
Authors: Chan David Y. L. , Moralli Daniela , Khoja Suhail , Monaco Zoia L.
Published: July 2017

We analyzed the effect of transcribed noncoding RNA centromeric satellites on chromosome segregation in normal human and murine stem and fibrosarcoma cells. The overexpression of different centromeric alphoid DNAs in all cell lines induced a marked increase in chromosome mis-segregation in anaphase. Overexpression of centromeric mouse minor satellite also increased chromosome instability in the murine stem but not in human cells. Analysis of chromosome segregation in vivo showed disturbances in the mitotic progression, which was frequently unresolved. Live cell imaging revealed that overexpression of centromeric satellites resulted in several different chromosomal morphological errors in the cell nuclei. Our findings correlated with other reports that several centromeric noncoding RNAs are detected in different carcinoma cells and their expression resulted in segregation errors. Our study furnishes further insights into a novel source of genomic instability in human and murine cells. It has recently been shown that noncoding centromeric RNAs are present in some form of cancer, and thus, overexpression of several types of centromeric noncoding RNAs may be useful as a specific maker for neoplastic cells.
Free and Forced Vibration of the Moderately Thick Laminated Composite Rectangular Plate on Various Elastic Winkler and Pasternak Foundations
Authors: Shi Dongyan , Zhang Hong , Wang Qingshan , Zha Shuai
Published: July 2017

An improved Fourier series method (IFSM) is applied to study the free and forced vibration characteristics of the moderately thick laminated composite rectangular plates on the elastic Winkler or Pasternak foundations which have elastic uniform supports and multipoints supports. The formulation is based on the first-order shear deformation theory (FSDT) and combined with artificial virtual spring technology and the plate-foundation interaction by establishing the two-parameter foundation model. Under the framework of this paper, the displacement and rotation functions are expressed as a double Fourier cosine series and two supplementary functions which have no relations to boundary conditions. The Rayleigh-Ritz technique is applied to solve all the series expansion coefficients. The accuracy of the results obtained by the present method is validated by being compared with the results of literatures and Finite Element Method (FEM). In this paper, some results are obtained by analyzing the varying parameters, such as different boundary conditions, the number of layers and points, the spring stiffness parameters, and foundation parameters, which can provide a benchmark for the future research.
Mesenchymal Stromal Cells Accelerate Epithelial Tight Junction Assembly via the AMP-Activated Protein Kinase Pathway, Independently of Liver Kinase B1
Authors: Rowart P. , Erpicum P. , Krzesinski J.-M. , Sebbagh M. , Jouret F.
Published: July 2017

Background. Mesenchymal stromal cells (MSC) are fibroblast-like multipotent cells capable of tissue-repair properties. Given the essentiality of tight junctions (TJ) in epithelial integrity, we hypothesized that MSC modulate TJ formation, via the AMP-activated kinase (AMPK) pathway. Liver kinase-β1 (LKB1) and Ca2+-calmodulin-dependent protein kinase kinase (CaMKK) represent the main kinases that activate AMPK.Methods. The in vitro Ca2+switch from 5 μM to 1.8 mM was performed using epithelial Madin-Darby canine kidney (MDCK) cells cultured alone or cocultured with rat bone marrow-derived MSC or preexposed to MSC-conditioned medium. TJ assembly was measured by assessing ZO-1 relocation to cell-cell contacts. Experiments were conducted using MDCK stably expressing short-hairpin-RNA (shRNA) against LKB1 or luciferase (LUC, as controls). Compound STO-609 (50 μM) was used as CaMKK inhibitor.Results. Following Ca2+switch, ZO-1 relocation and phosphorylation/activation of AMPK were significantly higher in MDCK/MSC compared to MDCK. No difference in AMPK phosphorylation was observed between LKB1-shRNA and Luc-shRNA MDCK following Ca2+switch. Conversely, incubation with STO-609 prior to Ca2+switch prevented AMPK phosphorylation and ZO-1 relocation. MSC-conditioned medium slightly but significantly increased AMPK activation and accelerated TJ-associated distribution of ZO-1 post Ca2+switch in comparison to regular medium.Conclusions. MSC modulate the assembly of epithelial TJ, via the CaMKK/AMPK pathway independently of LKB1.
Kindlin-2 Regulates the Growth of Breast Cancer Tumors by Activating CSF-1–Mediated Macrophage Infiltration
Authors: Sossey-Alaoui Khalid , Pluskota Elzbieta , Bialkowska Katarzyna , Szpak Dorota , Parker Yvonne , Morrison Chevaun D. , Lindner Daniel J. , Schiemann William P. , Plow Edward F.
Published: July 2017

Interplay between tumor cells and host cells in the tumor microenvironment dictates the development of all cancers. In breast cancer, malignant cells educate host macrophages to adopt a protumorigenic phenotype. In this study, we show how the integrin-regulatory protein kindlin-2 (FERMT2) promotes metastatic progression of breast cancer through the recruitment and subversion of host macrophages. Kindlin-2 expression was elevated in breast cancer biopsy tissues where its levels correlated with reduced patient survival. On the basis of these observations, we used CRISPR/Cas9 technology to ablate Kindlin-2 expression in human MDA-MB-231 and murine 4T1 breast cancer cells. Kindlin-2 deficiency inhibited invasive and migratory properties in vitro without affecting proliferation rates. However, in vivo tumor outgrowth was inhibited by >80% in a manner associated with reduced macrophage infiltration and secretion of the macrophage attractant and growth factor colony-stimulating factor-1 (CSF-1). The observed loss of CSF-1 appeared to be caused by a more proximal deficiency in TGFβ-dependent signaling in Kindlin-2–deficient cells. Collectively, our results illuminate a Kindlin-2/TGFβ/CSF-1 signaling axis employed by breast cancer cells to capture host macrophage functions that drive tumor progression. Cancer Res; 77(18); 5129–41. ©2017 AACR.
Posttranscriptional Regulation of PARG mRNA by HuR Facilitates DNA Repair and Resistance to PARP Inhibitors
Authors: Chand Saswati N. , Zarei Mahsa , Schiewer Matthew J. , Kamath Akshay R. , Romeo Carmella , Lal Shruti , Cozzitorto Joseph A. , Nevler Avinoam , Scolaro Laura , Londin Eric , Jiang Wei , Meisner-Kober Nicole , Pishvaian Michael J. , Knudsen Karen E. , Yeo Charles J. , Pascal John M. , Winter Jordan M. , Brody Jonathan R.
Published: July 2017

The majority of pancreatic ductal adenocarcinomas (PDAC) rely on the mRNA stability factor HuR (ELAV-L1) to drive cancer growth and progression. Here, we show that CRISPR-Cas9–mediated silencing of the HuR locus increases the relative sensitivity of PDAC cells to PARP inhibitors (PARPi). PDAC cells treated with PARPi stimulated translocation of HuR from the nucleus to the cytoplasm, specifically promoting stabilization of a new target, poly (ADP-ribose) glycohydrolase (PARG) mRNA, by binding a unique sequence embedded in its 3′ untranslated region. HuR-dependent upregulation of PARG expression facilitated DNA repair via hydrolysis of polyADP-ribose on related repair proteins. Accordingly, strategies to inhibit HuR directly promoted DNA damage accumulation, inefficient PAR removal, and persistent PARP-1 residency on chromatin (PARP-1 trapping). Immunoprecipitation assays demonstrated that the PARP-1 protein binds and posttranslationally modifies HuR in PARPi-treated PDAC cells. In a mouse xenograft model of human PDAC, PARPi monotherapy combined with targeted silencing of HuR significantly reduced tumor growth compared with PARPi therapy alone. Our results highlight the HuR–PARG axis as an opportunity to enhance PARPi-based therapies. Cancer Res; 77(18); 5011–25. ©2017 AACR.
SÃO PAULO NAS MUDANÇAS CLIMÁTICAS: ESTUDOS E PROPOSIÇÕES PARA A RESILIÊNCIA URBANA
Authors: Franco Maria De Assunção Ribeiro , Pellegrino Paulo Renato Mesquita , Marques Taícia Helena Negrin
Published: July 2017

O Workshop Labverde: “São Paulo nas Mudanças Climáticas: Estudos e Proposições para a Resiliência Urbana” foi proposto como parte das atividades relacionadas ao desenvolvimento do projeto aprovado pela Fapesp, “Infraestrutura Verde para a Resiliência Urbana às Mudanças Climáticas da Cidade de São Paulo”. O workshop ocorreu no dia 06 de fevereiro de 2017 nas dependencias da FAU-USP e contou com a participação de pesquisadores associados ao projeto e alunos de pós graduação, provindos de distintos institutos, e que desenvolvem suas pesquisas em temas afins.
American Heart Association’s Call to Action for Payment and Delivery System Reform
Authors: Bufalino Vincent J. , Berkowitz Scott A. , Gardner Timothy J. , Piña Ileana L. , Konig Madeleine , Bauman Mary Anne , Barbouche Michael , Creager Mark , Fonarow Gregg , Gibbons Ray , Meltzer David , Meltzer Neil , Schwamm Lee , Warner John
Published: July 2017

The healthcare system is undergoing a transition from paying for volume to paying for value. Clinicians, as well as public and private payers, are beginning to implement alternative delivery and payment models, such as the patient-centered medical home, accountable care organizations, and bundled payment arrangements. Implementation of these new models will necessitate delivery system transformation and will actively involve all fields of medical care, in particular medicine and surgery. This call to action, on behalf of the American Heart Association’s Expert Panel on Payment and Delivery System Reform, serves to offer support and direction for further involvement by the American Heart Association. In doing so, it (1) provides baseline review and definition of the present models and some of the early results of these delivery models, including outcomes; (2) initiates a conversation within the American Heart Association on the impact of payment and delivery system reform, as well as how the American Heart Association should engage in the interest of patients; (3) issues a call to action to our organization and to cardiovascular and stroke health professionals across the country to become educated about these models so to as to understand their impact on patient care; and (4) asks the government and other funding agencies, including the American Heart Association, to begin supporting and prioritizing meaningful research endeavors to further evaluate these models.
Temporal Trends of Single-Photon Emission Computed Tomography Myocardial Perfusion Imaging in Patients With Coronary Artery Disease
Authors: Jouni Hayan , Askew J. Wells , Crusan Daniel J. , Miller Todd D. , Gibbons Raymond J.
Published: July 2017

Background—

There has been a gradual decline in the prevalence of abnormal stress single-photon emission computed tomography (SPECT) myocardial perfusion imaging studies among patients without history of coronary artery disease (CAD). The trends of SPECT studies among patients with known CAD have not been evaluated previously.

Methods and Results—

We assessed the Mayo Clinic nuclear cardiology database for all stress SPECT tests performed between January 1991 and December 2012 in patients with history of CAD defined as having previous myocardial infarction, percutaneous coronary intervention, and coronary artery bypass grafting. The study cohort was divided into 5 time periods: 1991 to 1995, 1996 to 2000, 2001 to 2005, 2006 to 2010, and 2011 to 2012. There were 19 373 patients with a history of CAD who underwent SPECT between 1991 and 2012 (mean age, 66.2±10.9 years; 75.4% men). Annual utilization of SPECT in these patients increased from an average of 495 tests per year in 1991 to 1995 to 1425 in 2003 and then decreased to 552 tests in 2012 without evidence for substitution with other stress modalities. Asymptomatic patients initially increased until 2006 and then decreased. Patients with typical angina decreased, whereas patients with dyspnea and atypical angina increased. High-risk SPECT tests significantly decreased, and the percentage of low-risk SPECT tests increased despite decreased SPECT utilization between 2003 and 2012. Almost 80% of all tests performed in 2012 had a low-risk summed stress score compared with 29% in 1991 (
P
<0.001).

Conclusions—

In Mayo Clinic, Rochester, annual SPECT utilization in patients with previous CAD increased between 1992 and 2003, but then decreased after 2003. High-risk SPECT tests declined, whereas low-risk tests increased markedly. Our results suggest that among patients with a history of CAD, SPECT was being increasingly utilized in patients with milder CAD. This trend parallels reduced utilization of other stress modalities, coronary angiography, reduced smoking, and greater utilization of optimal medical therapy for prevention and treatment of CAD.
Validity of Cardiovascular Data From Electronic Sources
Authors: Ahmad Faraz S. , Chan Cheeling , Rosenman Marc B. , Post Wendy S. , Fort Daniel G. , Greenland Philip , Liu Kiang J. , Kho Abel N. , Allen Norrina B.
Published: July 2017

Background:

Understanding the validity of data from electronic data research networks is critical to national research initiatives and learning healthcare systems for cardiovascular care. Our goal was to evaluate the degree of agreement of electronic data research networks in comparison with data collected by standardized research approaches in a cohort study.

Methods:

We linked individual-level data from MESA (Multi-Ethnic Study of Atherosclerosis), a community-based cohort, with HealthLNK, a 2006 to 2012 database of electronic health records from 6 Chicago health systems. To evaluate the correlation and agreement of blood pressure in HealthLNK in comparison with in-person MESA examinations, and body mass index in HealthLNK in comparison with MESA, we used Pearson correlation coefficients and Bland-Altman plots. Using diagnoses in MESA as the criterion standard, we calculated the performance of HealthLNK for hypertension, obesity, and diabetes mellitus diagnosis by using
International Classification of Diseases, Ninth Revision
codes and clinical data. We also identified potential myocardial infarctions, strokes, and heart failure events in HealthLNK and compared them with adjudicated events in MESA.

Results:

Of the 1164 MESA participants enrolled at the Chicago Field Center, 802 (68.9%) participants had data in HealthLNK. The correlation was low for systolic blood pressure (0.39;
P
<0.0001). In comparison with MESA, HealthLNK overestimated systolic blood pressure by 6.5 mm Hg (95% confidence interval, 4.2–7.8). There was a high correlation between body mass index in MESA and HealthLNK (0.94;
P
<0.0001). HealthLNK underestimated body mass index by 0.3 kg/m
2
(95% confidence interval, –0.4 to –0.1). With the use of
International Classification of Diseases, Ninth Revision
codes and clinical data, the sensitivity and specificity of HealthLNK queries for hypertension were 82.4% and 59.4%, for obesity were 73.0% and 89.8%, and for diabetes mellitus were 79.8% and 93.3%. In comparison with adjudicated cardiovascular events in MESA, the concordance rates for myocardial infarction, stroke, and heart failure were, respectively, 41.7% (5/12), 61.5% (8/13), and 62.5% (10/16).

Conclusions:

These findings illustrate the limitations and strengths of electronic data repositories in comparison with information collected by traditional standardized epidemiological approaches for the ascertainment of cardiovascular risk factors and events.
Immediate Vascular Imaging Needed for Efficient Triage of Patients With Acute Ischemic Stroke Initially Admitted to Nonthrombectomy Centers
Authors: Boulouis Gregoire , Siddiqui Khawja-Ahmeruddin , Lauer Arne , Charidimou Andreas , Regenhardt Robert W. , Viswanathan Anand , Leslie-Mazwi Thabele M. , Rost Natalia , Schwamm Lee H.
Published: July 2017

Background and Purpose—

Current guidelines for endovascular thrombectomy (EVT) used to select patients for transfer to thrombectomy-capable stroke centers (TSC) may result in unnecessary transfers. We sought to determine the impact of simulated baseline vascular imaging on reducing unnecessary transfers and clinical-imaging factors associated with receiving EVT after transfer.

Methods—

We identified patients with stroke transferred for EVT from 30 referring hospitals between 2010 and 2016 who had a referring hospitals brain computed tomography and repeat imaging on TSC arrival available for review. Initial Alberta Stroke Program Early CT scores and TSC vascular occlusion level were assessed. The main outcome variable was receiving EVT at TSC. Models were simulated to derive optimal triaging parameters for EVT.

Results—

A total of 508 patients were included in the analysis (mean age, 69±14 years; 42% women). Application at referring hospitals of current guidelines for EVT yielded sensitivity of 92% (95% confidence interval, 0.84–0.96) and specificity of 53% (95% confidence interval, 0.48–0.57) for receiving EVT at TSC. Repeated simulations identified optimal selection criteria for transfer as National Institute of Health Stroke Scale >8 plus baseline vascular imaging (sensitivity=91%; 95% confidence interval, 0.83–0.95; and specificity=80%; 95% confidence interval, 0.75–0.83).

Conclusions—

Our findings provide quantitative estimates of the claim that implementing vascular imaging at the referring hospitals would result in significantly fewer futile transfers for EVT and a data-driven framework to inform transfer policies.
Ecology of benthic crustaceans in the Cautin river (38°S, Araucania region, Chile)
Authors: Vega Rolando , De los Ríos-Escalante Patricio , Encina Francisco , Mardones Alfonso
Published: July 2017

The Cautin river is located in the Araucania region, Chile (38°S), and is characterized by alterations through human interference in its surrounding basin, by the presence of introduced salmonids, and by its mixed regime, which originates from melting snow in summer and rains in winter. The fauna of this river includes an invertebrate fauna composed of both endemic and widespread species, which has, however, been only poorly studied until now. The aim of the present study was to make a review of the ecological role of the benthic inland water crustaceans of the River Cautin, in order to understand their importance in the ecosystem of the river. The literature revealed the presence of abundant populations of amphipods and freshwater crabs as well as of aquatic insects along the river’s course. Many of these crustaceans are prey for both introduced salmonids and native fishes. Similar results have been reported for other southern Argentinean and Chilean Patagonian rivers.
First records of Paratymolus pubescens Miers, 1879 and Litosus sexspinosus (Miers, 1884) (Decapoda, Brachyura, Inachidae) from Korean waters
Authors: Seo In-Soo , Kim Mi Hyang , Hwang Un-Ki , Yoon Sang-Pil
Published: July 2017

Two inachid crabs, Paratymolus pubescens Miers, 1879 from Geomundo and Litosus sexspinosus (Miers, 1884) from Jeju Island, are briefly described here. The two species are unique representatives of their respective genera in local waters. Morphological and distributional accounts of these species are discussed.
First record of Bopyrina ocellata (Isopoda, Bopyridae) from the Sea of Marmara, Turkey
Authors: Artüz M. Levent
Published: July 2017

The bopyrid isopod Bopyrina ocellata was obtained from the caridean shrimp Hippolyte inermis, collected on seagrass meadows of Posidonia oceanica and Zostera (Zostera) marina in the Sea of Marmara, Turkey. This is the first record of the genus Bopyrina from the Sea of Marmara. One-hundred-and-seventy-eight individuals of H. inermis were collected from the sampling area, of which 21 specimens (11.80%) were parasitized in the branchial chamber by B. ocellata.
us Colonial Governance of Superstition and Fanaticism in the Philippines
Authors: Wheatley Jeffrey
Published: July 2017

This article examines howuscolonial officials understood and utilized the categories of superstition, fanaticism, and religion during the occupation of the Philippines in the early twentieth century. I adapt Jason Josephson-Storm’s model of the trinary to explore the colonial politics of these categories. I focus on ideas about Filipino supernatural charms, typically referred to asanting anting. Civil administrators like ethnologist Dean Worcester and officers of the Philippine Constabulary blamed these charms for superstitious credulity and fanatical resistance againstusrule. As such, beliefs, practices, and communities categorized as superstitious or fanatical were targeted strategically for reformation or elimination. I argue that ideas about superstition, religion, and fanaticism were key parts ofuswar and policy, often serving racial projects of governance. Pursuing this line of inquiry allows scholars to see the material stakes of the category of religion and its proximate others.
icsid Jurisdiction with Regard to State-Owned Enterprises – Moving Toward an Approach Based on General International Law
Authors: Cortesi Giulio Alvaro
Published: July 2017

The decision of the ad hoc Committee in the case Tulip Real Estate v. Turkey of 2015 represents a new development in the methods applied by icsid tribunals to ascertain their own jurisdiction when the acts giving rise to the investor’s claim have been undertaken by a State-owned entity. Indeed, prior to this case, different views and trends had arisen over the years: some tribunals have addressed this matter by narrowing their field of analysis to the formal requirements of the claim, while others have focused on the issue of implicit designation. Lastly, there has been a growing trend, starting in 2009 with the case Toto Costruzioni v. Lebanon, where arbitrators have applied the rules on attribution at the jurisdictional stage. This last group of cases suggests that those arbitrators were developing an approach closer to that of general international law. The Tulip Real Estate v. Turkey Committee was the first annulment panel to comment on this latest development, although they commented without expressing much enthusiasm for it. The present article will focus on the issue of establishing an icsid tribunal’s jurisdiction when a State entity is involved in the proceedings, in order to cast some light on the rules that a tribunal should apply when deciding whether a dispute between the foreign investor and a State entity falls within its remit.
The Uncomfortable Balance between a Minority and a People: The Global/Local Disconnect
Authors: Menon Parvathi
Published: July 2017

The legitimacy of secessionist movements has emerged as an important debate, while the protection of minorities within a democracy has become merely of peripheral interest to international law. My project suggests that the advent of universalized (minority) rights re-conceptualized the majority-minority relationship and its balance, reducing the possibilities of political processes to balance the relationship. What was construed as a redress for dichotomous relationships between the oppressor and the oppressed through (the right to) self-determination, became a discourse between minority (identity) rights and a democratic entitlement, post-colonially. These norms universalized a demand to rethink minority protection, no longer from the perspective of advantaged and disadvantaged; rather, to introduce perspectives of individuals polarized around a personal characteristic in their identity thus establishing/reinforcing the inferiority of their identity within the hierarchy.
A taxonomic revision of the genus Pseudocamelina (Brasssicaceae, tribe Thlaspideae)
Authors: ESMAILBEGI SHOKOUH , LYSAK MARTIN A. , RAHIMINEJAD MOHAMMAD REZA , MIRTADZADINI MANSOUR , MUMMENHOFF KLAUS , AL-SHEHBAZ IHSAN A.
Published: July 2017

Pseudocamelina comprises nine species, of which seven are endemic to Iran and one each to Pakistan and Kurdistan Iraq. The new species P. bakhtiarica and P. kermanica are described, illustrated, and their relationships to nearest relatives are discussed. The new combination P. kurdica is proposed, and the genus Camelinopsis is reduced to synonymy of Pseudocamelina. Second-step lectotypifications are designated for P. camelinae and P. violacea.
Improving the Stable Surface Layer in the NCEP Global Forecast System
Authors: Zheng Weizhong , Ek Michael , Mitchell Kenneth , Wei Helin , Meng Jesse
Published: July 2017

This study examines the performance of the NCEP Global Forecast System (GFS) surface layer parameterization scheme for strongly stable conditions over land in which turbulence is weak or even disappears because of high near-surface atmospheric stability. Cases of both deep snowpack and snow-free conditions are investigated. The results show that decoupling and excessive near-surface cooling may appear in the late afternoon and nighttime, manifesting as a severe cold bias of the 2-m surface air temperature that persists for several hours or more. Concurrently, because of negligible downward heat transport from the atmosphere to the land, a warm temperature bias develops at the first model level. The authors test changes to the stable surface layer scheme that include introduction of a stability parameter constraint that prevents the land–atmosphere system from fully decoupling and modification to the roughness-length formulation. GFS sensitivity runs with these two changes demonstrate the ability of the proposed surface layer changes to reduce the excessive near-surface cooling in forecasts of 2-m surface air temperature. The proposed changes prevent both the collapse of turbulence in the stable surface layer over land and the possibility of numerical instability resulting from thermal decoupling between the atmosphere and the surface. The authors also execute and evaluate daily GFS 7-day test forecasts with the proposed changes spanning a one-month period in winter. The assessment reveals that the systematic deficiencies and substantial errors in GFS near-surface 2-m air temperature forecasts are considerably reduced, along with a notable reduction of temperature errors throughout the lower atmosphere and improvement of forecast skill scores for light and medium precipitation amounts.
Effect of Condensation Temperature on Formaldehyde Release from Durable Press Fabrics
Authors: Katovic Drago , Soljacic Ivo
Published: July 2017

We investigated formaldehyde release from cotton and polyester/cotton materials treated with DMEU and DMDHEU resins at different condensation temperatures. In the samples treated with DMEU, the amount of free formaldehyde was greater at lower condensation temperatures. Samples treated with DMDHEU gave similar results when the AATCC method for determining formaldehyde was used, but when the MITI method was used, the condensation temperature-formaldehyde curves showed a minimum at about 140°C. The release of formaldehyde is a slow process, because both methods gave similar curves when longer extraction times were used. Changing the extraction temperature gave a quantitative difference.
Central Vein Thrombophlebitis Associated with a Permanent Silastic Central Catheter
Authors: Alpert Jeffrey R. , Thomas John W. , Mullen James L.
Published: July 2017

The use of silastic catheters for total parenteral nutrition has greatly expanded. Their decided advantages of flexibility and minimal thrombogenicity favor their use in the long‐term nutritional support. This case report details the development of central vein thrombophlebitis associated with an indwelling central silastic catheter. This uncommon hazard of central venous catheterization is not eliminated by the use of silastic catheters.
Serum Zinc Concentrations: Contamination from Laboratory Equipment
Authors: Ralstin Janet O. , Schneider Philip J. , Blackstone Lenora , Ruberg Robert L.
Published: July 2017

The following experiment was designed because of high serum zinc reported in patients who were receiving total parenteral nutrition (TPN) concentrations. Blood samples were collected, divided into 3 containers: a clean glass control test tube, a vacuum collecting tube with a rubber stopper, and paraffin clot activator. It was found that compared to glass control tubes, vacuum collection with rubber stoppers contributed an average of 76 ± 14 μg/dl of zinc as contaminants. Moreover, tubes with a rubber stopper and clot activator contributed 198 ± 42 μg/dl of zinc as contaminants. It is concluded that care must be used to avoid trace element contaminants when plasma zinc concentrations are analyzed. Without proper methodology, including selection of the container in which the sample is taken, erroneous results will be reported.
Parenteral Nutrition Utilization: Evaluation of an Educational Protocol and Consult Service
Authors: Hickey Melanie M. , Munyer Thomas O. , Salem Ronald B. , Yost Richard L.
Published: July 2017

A two part study was undertaken to evaluate the effectiveness of an educational protocol and consult service on parenteral nutrition (PN) utilization. Forty‐one patient admissions were evaluated retrospectively and nine prospectively. Average length of hospital stay and number of days on PN were decreased significantly (p <.05). Frequency of adverse effects were also decreased significantly (p <.05). A positive trend toward selection of patients for enteral rather than PN was evidenced. Utilization of already available manpower and financial resources by this modified approach should contribute toward reducing costs and hazards of PN therapy, particularly for smaller hospitals with both limited requirements and resources, as well as for teaching institutions.
The Soviet Revolutions and India's Struggle for Freedom
Authors: Datta V. N.
Published: July 2017

The Soviet Revolutions and India's Struggle for Freedom: A Review Article: Vivekanand Shukla, Soviet Revolutions and the Indian National Movement. Perceptions of Indian Media, Delhi, 1989, 235p., Rs. 225.
High discordance in development and organ site distribution of tumors in rats and mice in NTP two-year inhalation studies
Authors: Smith Carr J , Anderson Steven P
Published: July 2017

The National Toxicology Program (NTP) reports 60 two-year inhalation studies in both mice and rats on single agents or closely related agents. “Cadmium and cadmium compounds” and “diesel exhaust particulates” were omitted from this analysis due to lack of results regarding a particular compound. No Ames test data were available for antimony trioxide, nickel sulfate hexahydrate, and indium phosphide. For antimony trioxide, a comet assay was used as a surrogate for the Ames test. To eliminate selection bias, all positive Ames assay test results and any statistically significant increase in lung tumor incidence over background in an NTP two-year inhalation study were accepted at face value. For the 58 compounds tested via inhalation by NTP, there is a high degree of discordance between mice and rats in the susceptibility to develop lung tumors. The causation of tumors at anatomical sites outside the lung via the inhalation route is also discordant in mice and rats, for example, 11/58 (19%) of agents tested in the NTP inhalation studies using mice and rats were negative in the Ames assay test and showed lung tumors in mice only. The ability to form lung tumors in mice in the absence of genotoxicity demonstrates that other mechanisms, for example, cytotoxicity followed by reparative cellular proliferation, might be involved. Mouse and rat data are discordant regarding the ability to induce tumors at organ sites outside the lungs—0/58 as compared with 16/58, respectively. Mice and rats display distinctly different patterns of both lung tumor development and development of tumors outside the lungs.
Eventual Cone Invariance
Authors: Kasigwa Michael , Tsatsomeros Michael
Published: July 2017

Eventually nonnegative matrices are square matrices whose powers become and remain (entrywise) nonnegative. Using classical Perron-Frobenius theory for cone preserving maps, this notion is generalized to matrices whose powers eventually leave a proper cone K â R^n invariant, that is, A^mK â K for all sufficiently large m. Also studied are the related notions of eventual cone invariance by the matrix exponential, as well as other generalizations of M-matrix and dynamical system notions.
La colección artística de Josefa Marín (1807-1871), condesa viuda de Velle
Authors: Martínez Plaza Pedro José
Published: July 2017

El artículo se centra en el estudio de la colección de Josefa Marín, condesa viuda de Velle, una de las de mayor interés del reinado de Isabel II y que fue muy diferente a las formadas por otros de sus contemporáneos. El análisis del archivo familiar y de otras fuentes diversas ofrece información sobre su colección, hasta ahora inédita, y permite ponderar la relevancia de esta, así como conocer la personalidad e intereses estéticos de esta coleccionista.
Lipidoak aztertu eta identifikatzeko TLC kromatografiaren eta MALDI masa-espektrometriaren arteko akoplamendua
Authors: Veloso Antonio
Published: July 2017

Geruza meheko kromatografia teknika (TLC, ingelesezko Thin Layer Chromatography) oso erabilia izan da hainbat molekularen banaketa eta karakterizaziorako. Bestalde, Matrix Assisted Laser Desorption Ionization Time of Flight Mass Spectrometry (MALDI-TOF MS) edo matrizez lagundutako laserraren bidezko desortzioionizazioa/hegaldi-denbora masa-espektrometria teknikaren erabilera gero eta gehiago hedatzen ari da molekula desberdinen analisia egiteko. Gainera, Imaging Mass Spectrometry (IMS) edo masa-espektrometriaren bidezko irudia izeneko teknikak, ahalbidetzen du ehun biologikoetan dauden lipidoen, proteinen eta farmakoen banaketa-irudiak lortzea eta teknika bikaina da molekula horien banaketa aztertzeko. Teknika honek lipido mota ezberdinen identifikazioa eta lokalizazioa ahalbidetzen du, konposatuaren edota familia kimikoaren aukera egin aurretik. Analizatu behar diren konposatuen aukera aldez aurretik egin behar ez denez, aukera dago irudiak sortzeko masa-espektrometroan detektatutako ioietatik abiatuta. Lan honetan, erakusten da lipidoen ikerkuntzarako oso lagungarria dela TLC xaflak eta MALDI IMS teknikak konbinatzea.
Hormigoi armatuaren eboluzioa linealki irakurtzeko ezintasuna. Espainiaren kasua (1896-1973)
Authors: Sagarna Maialen , Etxepare Lauren , Lizundia Iñigo , Uranga Eneko Jokin
Published: July 2017

Material artifizial baten kalitateak garaiz garai duen bilakaerak ez luke atzerakadarik izan behar. Garapen teknologikoak eta erabileraren jarraipenak bermatu beharko lukete kalitatearen hobekuntza, baldin eta egia balitz teknologiak eta zientziak, bide beretik, norabide berean eta abiadura berarekin egiten dutela beti aurrera. Alabaina, gertaera sozioekonomiko eta politikoek baldintzatu dezakete bilakaera hori, material baten teknologiaren eta ezaugarrien eboluzioa linealki irakurtzea ezinezko bihurtuz. Horren adibide garbia da Espainian hormigoi armatuak izan duen bilakaera. Artikulu honek hori azaltzea du helburu, Euskal Herrian aspaldian eraikitako hainbat egitura historikotan eskuraturiko datuak elkarren parean jarriz eta kronologikoki aztertuz.
Berehalako mezularitzan erabilitako hizkuntza: ezaugarriak eta erabiltzaileen pertzepzioak
Authors: Bereziartua Garbiñe
Published: July 2017

Con el desarrollo de la tecnología han emergido nuevas vías y nuevas maneras de comunicación y eso influye directamente en el uso del lenguaje. Entre las nuevas vías de comunicación que han surgido se encuentra la mensajería instantánea. En este artículo se analizan cuestiones relacionadas con el uso del lenguaje que hacen los adolescentes multilingües de un contexto sociolingüístico vascohablante en la comunicación por medio de mensajería instantánea.Por una parte, se analizan las características del lenguaje escrito utilizado en un contexto informal. Y por otra parte, se hace un análisis cualitativo de las percepciones que tienen los usuarios con respecto a ello. Al poner el foco en el euskara, el presente artículo intenta hacer una aportación que enriquezca la investigación que se está llevando a cabo sobre este tema a nivel internacional.
La duración del plano en el videoclip: hacia una categorización de los recursos formales en el vídeo musical contemporáneo.
Authors: Pérez Rufí José Patricio , Rodríguez López Jennifer
Published: July 2017

Este artículo tiene como objetivo descubrir prácticas habituales en la realización y la edición del vídeo musical actual. Incluso si el formato propone una gran variedad de alternativas, consideramos que la repetición de opciones formales podría conducir a la enunciación de un código. Creemos que determinados planos serán más frecuentes y que su duración vendrá determinada por el tamaño del encuadre, los posibles cambios de encuadre a través del movimiento de cámara y la duración de la acción representada con respecto a la duración de la acción filmada. Realizaremos un análisis de contenido sobre una muestra de videoclips.
Phi-Agreement in Past Participle Constructions
Authors: Castillo Concha
Published: July 2017

I argue in this paper that agreeing past participles are merged externally in the derivation in V endorsed with a feature [+resultative], whereas non-agreeing past participles are bound to value a feature [+perfective] against the have-auxiliary. Phi-agreement on the former kind of participle occurs since the meaning [+resultative] denotes a property of the logical object, which happens to merge in the position of sister to V-en. As postulated in standard frameworks, phi-agreement consists in that the V-en form values uninterpretable phi-features against the DP object. In contrast with agreeing past participles, non-agreeing past participles are merged externally in the form of V and they get their –en suffix in v valued against the have-auxiliary once the latter enters the derivation. The meaning or interpretation of this –en suffix is [+perfective] or [+anterior]. No phi-agreement occurs between these V-en forms marked [+perfective] and their logical object (whenever they select for one) since [+perfective] is a property of the event or situation as a whole, and not of the object. It is further suggested that the specific Agree relation that is phi-agreement appears not to be subject to configurations of asymmetric c-command, but to just occur on external Merge of the DP that bears the corresponding valued, interpretable phi-features.
Getting it All in the Right Order: the Love Plot, Trauma and Ethical Uncertainty in Rachel Seiffert’s Afterwards
Authors: Monnickendam Andrew
Published: July 2017

This article analyzes Seiffert’s Afterwards (2007), which, in marked contrast to her debut publication, The Dark Room (2001), has received scarce critical attention. Set in anodyne suburbia, Afterwards narrates the fate of two unglamorous ex-combatants and their trauma. Seiffert’s complex narrative binds together romance and PTSD in a double plot that intertwines the fate of a “squaddy” involved in a shooting incident in the Northern Ireland Troubles with that of a former RAF officer stationed in colonial Kenya. This article argues that beyond subjective issues of judgment, Seiffert shows an awareness that modern romance cannot combine with trauma, as the idea of healing is nonsensical in a world ruled by ethical uncertainty. Furthermore, Seiffert’s examination of trauma indicates that in fiction –as in life– author and reader have to confront questions of guilt, responsibility and the absence of forgiveness. Seiffert, drawing on ideas similar to Primo Levi’s, concludes the novel with the tragic irony that the more humane the perpetrator, the more distant closure becomes, leaving her main character locked in trauma and the reader ensnared in uncertainty.