bluuebunny/crossref_metadata_2025 huggingface dataset:
The Effectiveness of Using Augmented Reality Learning Media in Improving the Ability to Draw Sketches
Authors: Nurhidayat Martiyadi , Azhar Hanif
Published: November 2023

In practical, learning sketching at the concentration of product design this becomes a competence that requires must be able to students. Students are generation Z who have more insight into the effectiveness of using technology. While learning to draw sketches is less of an approach to technology so that competence is not achieved entirely. By creating learning media based on Augmantid Reality (AR) aims to carry out learning effectiveness to achieve competence in drawing sketches. This study uses qualitative methods with a descriptive approach, for data processing techniques using pretest and posttest control groups and Likert scales are able to analyze thoroughly. The population was 100 students and a random sampling technique was carried out into 20 respondents which were divided into 2 classes, namely the experimental class and the control class. There are results such as the following: the experimental class has a pretest value of 19 points with a description of Cannot and a posttest value of 34 points with a very clear can be after applying AR-based learning media, while the control class has a pretest value of 18.5 points with a description of Not being able and a posttest value of 24.5 points with a description of not being able to and a posttest value of 34 points with clarity can be applied after applying power point learning media. The difference after applying AR-based learning media is that it guarantees to increase the competence of sketching skills.
Impressions of a Brazilian in New Delhi
Authors: Durão Fabio
Published: November 2023

This text is a collection of 18 fragments written during a trip to New Delhi during February and March 2014. They can be seen as a discontinuous short travel diary which develops comparative cultural criticism between Brazil and India from ordinary experiences. As they try to develop concepts from everyday occurrences they also end up fusing academia and tourism in a way that both are eventually improved. [Article copies available for a fee from The Transformative Studies Institute. E-mail address: journal@transformativestudies.org Website: http://www.transformativestudies.org ©2023 by The Transformative Studies Institute. All rights reserved.]
Quests for a Change of Territories: Forms of Dystopia and Transfiction in La autopista: the movie, by Jorge Enrique Lage
Authors: Timmer Nanne
Published: November 2023

The Cuban literary tradition is closely linked to the idea of a “national literature,” reducing narrative to a specific axis of space and time. The authors of the so-called Generación Zero (Generation Zero) experiment with the elements of this “national literature,” or, Literature-Nation (Aguilera 2002), and de-territorialize narrative while working with its tropes. Departing from the idea of ‘transfiction’ (Aguilera 2015) and the idea that utopia is not only referring to a time and space, but also to a genre, I will analyse the novel La autopista: the movie (2015), by Jorge Enrique Lage from that perspective. The novel stretches the binary between utopic and dystopic fiction articulating an ambiguous future that the present article explores through the narrative possibilities of the (trans)generic, (trans)spatial, and (trans)temporal. While easy to conceive of this novel as dystopic, futuristic, and apocalyptic text, it rejects the limits of space, time, and the dystopic genre. The article thus invites a re-thinking of the role of literature in the Cuban tradition as merely representative of territory or nation. [Article copies available for a fee from The Transformative Studies Institute. E-mail address: journal@transformativestudies.org Website: http://www.transformativestudies.org ©2023 by The Transformative Studies Institute. All rights reserved.]
PENERAPAN MODEL PEMBELAJARAN PROBLEM BASED LEARNING DENGAN MEDIA PEMBELAJARAN KARTA ORGAMAWA UNTUK MENINGKATKAN KEMAMPUAN BAHASA SISWA SD
Authors: Lestiana Rofiah Dwi , Pratiwi Cerianing Putri , Sari Ima Yana
Published: November 2023

Penelitian ini bertujuan untuk mengetahui aktivitas belajar siswa kelas V dalam menentukan ide pokok dengan menggunakan model pembelajaran Problem Based Learning dan media pembelajaran Karta Orgamawa (Kartu Cerita Kartu Organ Gerak Manusia dan Hewan) dan untuk mengetahui hasil belajar siswa kelas V pada pembelajaran menentukan ide pokok dengan menggunakan model pembelajaran Problem Based Learning dan media pembelajaran Karta Orgamawa (Kartu Cerita Kartu Organ Gerak Manusia dan Hewan). Penelitian dilakukan di SDN Bangunasri. Subjek penelitian berjumlah 16 siswa dengan jumlah siswa laki-laki sebanyak 3 siswa dan perempuan 13 siswa. Penelitian ini menggunakan Penelitian Tindakan Kelas (PTK) yang dikembangkan oleh Kemmis & Mc Taggart. Tahap pelaksanaannya dimulai dari rencana tindakan, pelaksanaan tindakan, observasi, dan diakhiri refleksi. Metode penelitian yang digunakan yaitu tes tertulis, observasi, dan dokumentasi. Teknik analisis data menggunakan teknik deskriptif dengan analisis kuantitatif. Hasil penelitian menunjukkan bahwa terdapat peningkatan kemampuan siswa dalam menentukan ide pokok dibuktikan dengan nilai hasil tes mereka dengan rata-rata pada siklus I adalah 74,68 meningkat pada siklus II menjadi 83,43 dengan peningkatan sebanyak 8,75. Berdasarkan temuan-temuan pada saat penelitian dapat disimpulkan bahwa penerapan model pembelajaran Problem Based Learning  dan media pembelajaran Karta Orgamawa (Kartu Cerita Kartu Organ Gerak Manusia dan Hewan) dapat meningkatkan kemampuan menentukan ide pokok siswa kelas V di SDN Bangunasri.

Kata-kata Kunci: Problem Based Learning, Media Kartu Cerita, Ide Pokok
PENGELOLAAN SARANA DAN PRASARANA PEMBELAJARAN PENDIDIKAN AGAMA ISLAM
Authors: Mustakim Sulfiani , Isnaini Rahmatun Lukluk , Mulyawan Arif , Fitria Faning Maulida
Published: November 2023

Penelitian ini bertujuan untuk memahami bagaimana sarana pembelajaran dikelola, mencakup seluruh proses mulai dari perencanaan, pengadaan, pemeliharaan, hingga tahap penghapusan. Metode penelitian yang diterapkan adalah kualitatif dengan pendekatan deskriptif interpretatif. Metode pengumpulan data melibatkan tiga aspek utama, yaitu wawancara, observasi, dan dokumentasi, sementara validitas data diuji melalui reliabilitas, transferabilitas, dan verifiabilitas. Proses analisis data dalam penelitian ini melibatkan penerapan teknik analisis interaktif, yang mencakup reduksi data, penyajian data, dan penarikan kesimpulan. Responden dalam penelitian ini mencakup kepala sekolah, pengelola perpustakaan agama, staf bidang sarana dan prasarana, serta guru mata pelajaran PAI. Sumber data yang digunakan mencakup data primer dan sekunder. Hasil penelitian menunjukkan bahwa pengelolaan sarana dan prasaran pembelajaran di SDN Lempuyangan 1 Yogyakarta sudah dilakukan berdasar pada standar proses. Pengelolaan tersebut meliputi: (a) perencanaan sarana pembelajaran sudah dilakukan dengan baik, (b) pengadaan buku pembelajaran, (c) pemeliharaan pembelajaran, pihak sekolah sudah melakukan pemeliharaan sarana dengan baik dengan cara menyimpan dengan rapi apabila telah digunakan untuk menjaga agar sarana pembelajaran tidak mudah rusak. dan (d) penghapusan sarana pembelajaran, dilakukan dengan pencatatan buku pembelajaran yang tidak layak digunakan.
GOES observations of solar protons during ground level enhancements
Authors: Rodriguez Juan V. , Kress Brian T.
Published: November 2023

Since 1974, the U.S. National Oceanic and Atmospheric Administration (NOAA) has observed solar proton fluxes from the Geostationary Operational Environmental Satellites (GOES). These observations frequently have
served as measurements of the primary component of ground level enhancements (GLEs). Until March 2020, when GOES-14 and -15 were turned off, solar proton measurements were made by the Energetic Particle Sensor
(EPS) and the High-Energy Proton and Alpha Detector (HEPAD). EPS had poor energy resolution above 100 MeV, and NOAA derived a >100 MeV integral flux from the EPS channels to support alerts issued by the Space
Weather Forecast Office. HEPAD provided some energy resolution in the 330-700 MeV range and a >700 MeV integral channel. Starting with GOES-16, a new instrument called the Solar and Galactic Proton Sensor (SGPS)
has replaced EPS and HEPAD. SGPS uses three solid-state telescopes to observe solar proton fluxes between 1 and 500 MeV with a >500 MeV integral channel. The >100 MeV integral flux is now derived from SGPS
observations and includes the >500 MeV flux in its derivation. In this paper, we describe the older EPS and HEPAD observations and the new SGPS solar proton observations. We also compare methods for detecting
solar proton event onsets currently used with GOES and neutron monitor observations and recommend some innovations.
What do we learn from ground level enhancements?
Authors: Papaioannou Athanasios
Published: November 2023

Ground-level enhancements (GLEs) comprise the high-energy end of solar energetic particle (SEP) events and constitute a special class in which ions are accelerated to relativistic energies, causing a significant
sudden increase of cosmic rays at ground-based detectors, mainly at neutron monitors (NMs). GLEs require acceleration processes capable of producing particles with sufficient energy to allow their secondary
products to reach the terrestrial ground and be detected. Moreover, due to their fast propagation, relativistic protons in GLEs are particularly useful for the identification of SEP sources at the Sun (i.e. flare,
coronal mass ejections) - nonetheless, the debate about the exact nature of GLE mechanisms is still ongoing. GLEs are further critical for the establishment of Space Weather services and the accurate determination
of their imposed radiation risk. In this tutorial, an overview of GLEs with respect to their historical identification, measurements from the worldwide neutron monitor network, modeling and forecasting efforts will
be provided. In addition, a hands-on tutorial that will demonstrate how the Neutron Monitor Database (NMDB) can be utilized for GLE analysis will be conducted.
Haleakala neutron monitor redeployment and calibration with AMS data
Authors: Consolandi Cristina , Bindi Veronica , Corti Claudio , Nikonov Nikolay , Ryan James , Legere Jason , Nuntiyakul Waraporn
Published: November 2023

Since the 1950s, neutron monitors (NMs) have successfully measured both the long-term and the short-term variation of Galactic Cosmic Rays (GCRs). NMs are also sensitive to solar energetic particles (SEPs) and solar
neutron particles (SNPs), both detected as ground level enhancements. Since SNPs are not affected by the interplanetary magnetic field, they retain direct information about the nuclear reactions happening near the
SEP acceleration site. The global NM network has still a huge gap over the equatorial Pacific for measuring high energy GCRs and SNPs which are best measured at low latitudes. We plan to extend the coverage of the
world wide NM network for SNP and GCR observations by redeploying the Haleakala NM station (HLEA) on Maui, in time for the upcoming solar maximum (around 2025). Since NMs can only measure the total count rate, it is
not trivial to derive the actual particle flux and to compare different station responses. We plan to calibrate the HLEA with the future AMS daily proton fluxes, extended until the ISS decommission date now planned
in 2031, and to perform extensive Mote Carlo simulations of the detector and surrounding environment. The initial phase of the project has already started. Status of the upcoming HLEA NM detector is reported.
Magnetized Accretion Disks with Outflows for Changing-look AGNs
Authors: Wu Wen-Biao , Gu Wei-Min
Published: November 2023

Changing-look active galactic nuclei (CL-AGNs) challenge the standard accretion theory, owing to their rapid variability. Recent numerical simulations have shown that, for the sub-Eddington accretion case, the disk is magnetic pressure–dominated, thermally stable, and geometrically thicker than the standard disk. In addition, outflows were found in the simulations. Observationally, high blueshifted velocities absorption lines indicate that outflows exist in AGNs. In this work, based on the simulation results, we investigate the magnetic pressure–dominated disk, and find that the accretion timescale is significantly shorter than that of the standard thin disk. However, such a timescale is still longer than that of the CL-AGNs. Moreover, if the role of outflows is taken into account, then the accretion timescale can be shortened even further. By the detailed comparison of the theoretical accretion timescale with the observations, we propose that the magnetic pressure–dominated disk incorporating outflows can be responsible for the rapid variability of CL-AGNs.
Analyses of ∼0.05–2 MeV Ions Associated with the 2022 February 16 Energetic Storm Particle Event Observed by Parker Solar Probe
Authors: Giacalone Joe , Cohen C. M. S. , McComas D. J. , Chen X. , Dayeh M. A. , Matthaeus W. H. , Klein K. G. , Bale S. D. , Christian E. R. , Desai M. I. , Hill M. E. , Khoo L. Y. , Lario D. , Leske R. A. , McNutt R. L. , Mitchell D. G. , Mitchell J. G. , Malandraki O. , Schwadron N. A.
Published: November 2023

We present analyses of 0.05–2 MeV ions from the 2022 February 16 energetic storm particle event observed by Parker Solar Probe's (PSP) IS⊙IS/EPI-Lo instrument at 0.35 au from the Sun. This event was characterized by an enhancement in ion fluxes from a quiet background, increasing gradually with time with a nearly flat spectrum, rising sharply near the arrival of the coronal mass ejection (CME)–driven shock, becoming nearly a power-law spectrum, then decaying exponentially afterward, with a rate that was independent of energy. From the observed fluxes, we determine diffusion coefficients, finding that far upstream of the shock the diffusion coefficients are nearly independent of energy, with a value of 1020 cm2 s−1. Near the shock, the diffusion coefficients are more than 1 order of magnitude smaller and increase nearly linearly with energy. We also determine the source of energetic particles, by comparing ratios of the intensities at the shock to estimates of the quiet-time intensity to predictions from diffusive shock acceleration theory. We conclude that the source of energetic ions is mostly the solar wind for this event. We also present potential interpretations of the near-exponential decay of the intensity behind the shock. One possibility we suggest is that the shock was overexpanding when it crossed PSP and the energetic particle intensity decreased behind the shock to fill the expanding volume. Overexpanding CMEs could well be more common closer to the Sun, and this is an example of such a case.
Influence of an Upstream Dynamic Pressure Pulse on Venus–Solar Wind Interaction by Multispecies Magnetohydrodynamic Simulation
Authors: Li Yun , Xiong Ruijing , Lu Haoyu , Cao Jinbin , Zhu Tianle , Li Guokan , Li Shibang
Published: November 2023

As an unmagnetized planet, Venus does not have a global dipole magnetic field like Earth. The solar wind interacts directly with the Venusian ionosphere. In this paper, the interaction between solar wind and the Venusian upper atmosphere is investigated by conducting a three-dimensional multispecies magnetohydrodynamic (MHD) model, in which the Venusian ionosphere is developed self-consistently by considering chemical reactions among four major ion species (H+, O2
+, O+, and CO2
+). Based on this developed MHD model, we mainly study the effects of the impulsive solar wind dynamic pressure on the interaction process. Simulation results reveal that the locations of the bow shock and magnetic pileup boundary show an abrupt compression, then expansion, and finally shrinkage to reach a new steady state with the influence of the impulsive dynamic pressure. The recovery time of the large-scale magnetic field is a few minutes. In addition, the peak escape fluxes are enhanced by about 1 order of magnitude due to the increased solar wind dynamic pressure pulse.
The Impact of Angular Momentum Loss on the Outcomes of Binary Mass Transfer
Authors: Willcox Reinhold , MacLeod Morgan , Mandel Ilya , Hirai Ryosuke
Published: November 2023

We use the rapid binary population synthesis code COMPAS to investigate commonly used prescriptions for the determination of mass transfer stability in close binaries and the orbital separations after stable mass transfer. The degree of orbital tightening during nonconservative mass transfer episodes is governed by the poorly constrained angular momentum carried away by the ejected material. Increased orbital tightening drives systems toward unstable mass transfer leading to a common envelope. We find that the fraction of interacting binaries that will undergo only stable mass transfer throughout their lives fluctuates between a few and ∼20% due to uncertainty in the angular momentum loss alone. If mass transfer is significantly nonconservative, stability prescriptions that rely on the assumption of conservative mass transfer underpredict the number of systems which experience unstable mass transfer and stellar mergers. This may substantially impact predictions about the rates of various transients, including luminous red novae, stripped-envelope supernovae, X-ray binaries, and the progenitors of coalescing compact binaries.
Professor Ahmet Hadrovic's Philosophy of Architecture
Authors: Hadrovic Ahmet
Published: November 2023

As a part of the Universe, man is, by himself, such a complex reality that, as long as he exists, he will not be fully 'explored'. Before the explicit elaboration of 'his philosophy of architecture', the Author will present a brief description of 'his life path', since he is convinced that it is the material for his philosophy. In this description, he used excerpts from his published book (2019) of philosophical content – “Man: something or nothing”. The author is convinced that the text presented in this work is only one view of man about man. It is true to the extent that the very existence of the Author is true.
Integration of acceptability analyses into an adaptive landscape co-design and management – The acceptability and landscape design cycle (ALDC)
Authors: Busse Maria , Heitepriem Nico , Zscheischler Jana , Siebert Rosemarie
Published: November 2023

1. Acceptability analyses of place-based innovations provide crucial in-depth knowledge (e.g., perceptions and values on landscapes) for the sustainability transformation of landscapes. However, previous acceptability analyses often neglect complex and on-going processes. We argue that for the design of a sustainability-oriented transformation and to address spatial and temporal dynamics in landscapes, an operational heuristic is needed that integrates acceptability analyses into an adaptive landscape co-design and management approach.

2. Therefore, this conceptual-empirical paper introduces the concept of the ‘acceptability and landscape design cycle’(ALDC), which is based on findings from various transdisciplinary innovation processes in the Spreewald region (Germany). It is composed of four iterative phases: (1) defining the preconditions for acceptability analysis, (2) conducting the acceptability analysis, (3) integrating the results into the landscape development strategy, and (4) re-designing and refining it.

3. We illustrate the application of these phases using the case study of the Cultural Landscape Spreewald. The paper provides practical implementation guidelines of the ALDC and contributes to a better understanding of the dynamics of acceptability decisions in landscape transformation processes. Furthermore, it can advance the understanding of how coevolution of socio-ecological systems occurs.
Synotis jinpingensis (Asteraceae, Senecioneae), a new species with white ray florets from southeastern Yunnan, China
Authors: Zhao Liao-Chen , Chen Ren , Yu Zhi-Yong , Tang Ming , Yang Qin-Er
Published: November 2023

Synotis jinpingensis (Asteraceae, Senecioneae), a new species from Jinping county in southeastern Yunnan province, China, is described and illustrated. This species is distinguished by having white ray florets in the genus Synotis, in which only species with yellow ray florets have been hitherto known. In habit and leaf shape S. jinpingensis is most closely similar to S. duclouxii, a species occurring in southwestern Guizhou, southern Sichuan and northeastern Yunnan, China, but differs, in addition to the color of ray florets, by having fewer lateral veins of leaves, obviously longer bracts of calyculus, and larger phyllaries. The membership of the new species within Synotis is strongly corroborated by evidence from floral micromorphology and phylogenetic analyses based on ITS sequence data. Color photographs of living plants, a distribution map, and provisional IUCN status of S. jinpingensis are provided.
Distributed Team Working - Approaches for DiSSCo
Authors: Hardy Helen , French Lisa , Humphries Josh , von Mering Sabine , Giere Peter , Berger Frederik , Koivunen Anne , Grieb Jonas , Vipp Martin , Smith Vincent
Published: November 2023

As a highly decentralised research infrastructure, the Distributed System of Scientific Collections (DiSSCo) will need to develop cross-institutional teams, adopting work practices where individual staff are intensively working collectively on common tasks in a distributed environment. These flexible and distributed working practices will be essential to the delivery of the research infrastructure across a wide range of delivery partners and a geographically dispersed set of scarce resources and skills, particularly in more technical roles. Since work to consider secondment and distributed working in DiSSCo was first envisaged, there has been a step change in distributed working owing to the Covid-19 pandemic and lockdowns or other restrictions to where work could take place. This report examines distributed team working practices and how they have changed, through interviews with a range of key roles across DiSSCo Prepare institutions. It briefly examines key project management and technical team delivery techniques. It documents how some of these approaches have been piloted within DiSSCo Prepare for the development, testing and delivery of DiSSCo Policy and Digital Maturity tools. Finally, bringing this together with previous work on secondment policies and practices for DiSSCo, we make recommendations about how secondment and distributed team working can be approached to enhance DiSSCo capabilities and the likelihood of successful implementation of the research infrastructure.
Dette publique, retour de l’inflation et policy mix : qu’enseigne l’expérience contemporaine ?
Authors: Eboué Chicot , Villieu Patrick
Published: November 2023

L’introduction générale au numéro spécial de la RFE, revient sur les grands enjeux liés à la soutenabilité de la dette publique d’une part, et à l’identification d’une combinaison optimale entre politique budgétaire et politique monétaire, d’autre part. À cette occasion, les conditions nécessaires à la soutenabilité de la dette publique sont évoquées, aussi bien pour les pays riches que pour les pays pauvres d’Afrique. La « borne inférieure de taux d’intérêt », qui a prévalu de 2009 à 2020, ayant conduit à la dominance budgétaire, est à l’origine de l’assignation de la politique monétaire à l’objectif intermédiaire de l’endettement public. Il en est résulté une tolérance inflationniste plus grande à partir de 2021, suite aux crises imprévisibles de la Covid-19 et la guerre russoukrainienne. Il en découle la nécessité de redéployer les dispositifs des politiques budgétaire et monétaire, afin d’éviter d’étouffer la croissance, tout en combattant l’inflation. Cette introduction examine les différentes options possibles, dont les réformes des règles budgétaires, le verdissement de la politique monétaire et la coordination budgétaire verticale. Successivement, la contribution des auteurs à ce numéro spécial est évaluée.
Dette publique et policy mix climatique : l’éclairage des modèles macroéconomiques stocks-flux cohérents
Authors: Mazier Jacques , Reyes Luis
Published: November 2023

L’article examine l’apport des modèles stocks-flux cohérents (SFC) à la définition d’un policy mix vert facilitant la mise en œuvre d’une politique de transition climatique. Dans une première partie, les modèles SFC traditionnels sont utilisés pour évaluer si les politiques monétaires non conventionnelles peuvent accroître les marges de manœuvre budgétaires et contribuer ainsi au financement du coût élevé de la transition climatique. Dans une seconde partie, l’approche est élargie aux modèles SFC mondiaux ou nationaux intégrant la dimension environnementale. Certaines modalités d’un policy mix vert (quantitative easing vert, politique sélective du crédit, mesures fiscales, dépenses publiques plus actives) sont examinées dans ce cadre.
Le Grand défi biomédicaments
Authors: Dequier Emmanuel
Published: November 2023

Avec l’arrivée des biomédicaments, la filière des médicaments est en train de vivre une véritable révolution. Ces médicaments qui permettent de soigner des cancers jusque-là incurables ou bien de traiter des maladies génétiques, entraînent une transformation profonde de l’industrie de santé avec le déploiement de nouvelles technologies de production et de nombreux challenges encore à relever pour l’industrialisation des traitements les plus innovants. Le Grand défi biomédicaments puis la stratégie d’accélération Biothérapie et Bioproduction de thérapies innovantes ont permis de poser les premières bases de structuration de la filière afin que la France devienne un des leaders européens de la production des biothérapies.
Le rôle de l’Agence de l’Innovation en Santé (AIS)
Authors: Alter Lise
Published: November 2023

Au lendemain d’une pandémie immuablement transformatrice, le gouvernement a répondu en se dotant d’une stratégie visant à faire de la France la première nation européenne innovante et souveraine en santé. Cette dernière prend la forme du plan innovation santé 2030, volet santé de France 2030, doté de 7,5 milliards d’euros avec la double ambition suivante : transformer durablement le secteur clef qu’est la santé, tout en positionnant la France comme leader de l’innovation de demain. L’Agence de l’Innovation en Santé (AIS) en constitue la pierre angulaire et a pour vocation d’anticiper, accélérer et simplifier l’accès aux innovations en France sur l’entièreté de la chaîne de valeur. Véritables révolutions pour les patients, le système de santé, et l’industrie, les innovations dans le domaine des biothérapies et bioproductions sont expressément accompagnées par l’AIS afin de fluidifier leur intégration dans l’écosystème et les rendre accessibles au plus vite, au plus grand nombre.
Les biomédicaments dérivés du plasma et de protéines thérapeutiques : enjeux et perspectives
Authors: Guedegbe Herbert J. , Burlot Ludovic , Delavault Patrick
Published: November 2023

Les médicaments biologiques dérivés du plasma et des protéines thérapeutiques sont une classe particulière de biomédicaments assez méconnue et ce, malgré des applications pour le traitement de maladies rares et souvent graves telles que les maladies génétiques, les cancers et les maladies inflammatoires. Les processus industriels de fabrication allant du fractionnement à la sécurisation biologique du plasma ainsi que de la production et la purification des protéines recombinantes sont décrits dans ce présent article. Bien que ces deux types de biomédicaments diffèrent principalement au niveau de leur source de production mais aussi des procédés en amont, les enjeux restent comparables et renvoient souvent à des questions de souveraineté sanitaire et de positionnement stratégique de la France dans un contexte de forte compétition autour du marché mondial du médicament biologique, marché en pleine croissance.
Les stratégies dans la lutte contre les maladies infectieuses : le rôle de l’ANRS | Maladies infectieuses émergentes
Authors: Telford Erica , Porcheray Fabrice , Halfen Sandrine , Pasquet Armelle , Pulik Nicolas , Fanjat Marion , Raoul Hervé , Yazdanpanah Yazdan
Published: November 2023

La crise Covid-19 a mis en évidence le besoin d’anticipation des crises sanitaires. L’ANRS I Maladies Infectieuses Émergentes, agence issue de la fusion de l’ANRS (Agence Nationale de Recherche sur le SIDA) et du consortium REACTing (REsearch and ACTion targeting emerging infectious diseases), a été créée dans ce contexte. C’est une agence autonome de l’Inserm qui anime, évalue, coordonne et finance la recherche sur le VIH/sida, les hépatites virales, les infections sexuellement transmissibles, la tuberculose et les maladies infectieuses émergentes et ré-émergentes. La stratégie de l’agence s’intègre dans un large cadre d’initiatives structurantes mises en place au niveau national et international, allant de la recherche fondamentale au développement et à la bioproduction, pour améliorer la préparation et la réponse aux épidémies. Les aspects liés à l’innovation, aux enjeux sociétaux, ainsi qu’à la collaboration internationale sont particulièrement renforcés pour répondre à ces objectifs.
Les vecteurs viraux en immunothérapie du cancer
Authors: Quéméneur Éric
Published: November 2023

Par leurs propriétés uniques, les vecteurs viraux sont incontournables en thérapie génique ou pour l’ingénierie des thérapies cellulaires. Leur usage direct en tant qu’agent d’immunothérapie antitumorale, soit sous la forme de virus oncolytique ou comme vaccin thérapeutique, fait encore l’objet d’importants travaux de recherche et développement. L’approbation de T-Vec en 2015 a dopé le domaine des oncolytiques et près d’une vingtaine de produits sont en cours d’évaluation clinique. Les vecteurs non réplicatifs bénéficient de l’engouement général pour la vaccination thérapeutique et de l’arrivée des nouvelles classes d’antigènes. Ces deux classes d’immunothérapies virales trouvent parfaitement leur place dans les stratégies de combinaison avec d’autres modalités de traitement. Le secteur reste dynamique sur le plan de l’innovation technologique et clinique. Cet article évoque également les défis qui restent à relever pour que les vecteurs viraux puissent devenir une classe thérapeutique reconnue et industriellement mature.
Les enjeux éthiques soulevés par les biothérapies
Authors: Duée Pierre-Henri , Crozier Sophie , Jusot Florence , Delfraissy Jean-François
Published: November 2023

Depuis plusieurs années, de nouveaux médicaments, issus de la recherche biomédicale, apparaissent pour traiter des maladies graves telles que les cancers ou les maladies inflammatoires. Ces nouvelles thérapies font appel à des secteurs de recherche récents en rupture avec la recherche de nature chimique ou biochimique. Elles sont souvent personnalisées et présentent un coût particulièrement élevé. Ces caractéristiques soulèvent des questions éthiques, à commencer par celle du « juste prix » de ces innovations thérapeutiques, mais aussi par celle de la priorisation dans leur accès. Le travail d’analyse proposé dans cet article s’appuie sur les avis du Comité consultatif national d’éthique, notamment l’avis 135 adopté le 24 septembre 2020. Ce travail insiste aussi sur l’importance de se donner un cadre général afin de réguler le flux de ces nouvelles thérapies et de prendre en compte les enjeux de santé publique avec des repères éthiques qui portent sur les notions d’intérêt général et le principe d’équité. Enfin, une évolution structurelle ouvrant sur de nouveaux modèles économiques serait opportune, ce qui supposera néanmoins une évolution culturelle importante.
A catástrofe pós-colonial: ler António Lobo Antunes «à rebours»
Authors: Lentina Alda Maria
Published: November 2023

Le roman As Naus (Le retour des Caravelles) d’António Lobo Antunes propose une révision du passé historique portugais, en offrant une relecture de la Révolution du 25 avril 1974 comme événement traumatique et catastrophique. En effet, sur fond de guerre et de décolonisation africaine, l’auteur nous transmet une vision dysphorique du contexte révolutionnaire portugais, ceci en adoptant le point de vue des « retornados », ex-colons fuyant l’Afrique, revenant vers la mère Patrie : le Portugal. Nous assistons ainsi à une « navigation à contre-courant », celle où les « héros de jadis », relégués aux marges de la société portugaise, se transforment en personnages nomadiques et « border-line ». Dans ces conditions, l’espace des marges représente « l’envers du décor » de la société portugaise, un monde sens dessus dessous, où règnent la sauvagerie et l’abjection. C’est à travers ces motifs apocalyptiques que l’auteur touche à l’un des fondements de l’identité portugaise, à savoir, celle d’une grande Nation au centre d’un Empire.
La idea de catàstrofe en la dramatúrgia catalana contemporània (2002-2012): representació i pulsió catastròfica del text teatral
Authors: Rollet Aymeric
Published: November 2023

L’article examine l'hypothèse d'une incidence des grandes catastrophes (terrorisme, guerres, famine, épidémies, changement climatique, etc.) sur la littérature dramatique catalane postérieure aux événements du 11 septembre 2001. On analyse plusieurs pièces écrites entre 2002 et 2012, selon deux approches distinctes : d'une part, une approche de nature thématique qui consiste à évaluer la place et à décrire la représentation de la catastrophe dans le théâtre écrit au cours de la période considérée ; d'autre part, une approche de nature formelle et esthétique qui consiste à se demander dans quelle mesure les grandes catastrophes, en modifiant de manière significative le regard que les hommes portent sur le réel, ont pu se traduire dans le théâtre catalan et déterminer ainsi la forme dramatique elle-même.
Le grand vertige
Authors: Grimaud Emmanuel , Wacquez Julien , Halloy José
Published: November 2023

Le futur est-il écrit à l’avance ? La vie est-elle un accident ou une nécessité de l’univers ? La Terre respire-t-elle vraiment ? Le physicien José Halloy revient sur son parcours intellectuel et sur son travail interdisciplinaire — à la croisée des sciences humaines et sociales, des sciences dites de la « nature », de la prospective et de la littérature de science-fiction — pour nous aider à mieux comprendre les enjeux de l’Anthropocène. Il ne nous propose rien de moins que le plus grand des vertiges, en nous faisant voyager de la femtoseconde au milliard d’années, de la mitochondrie à la planète tout entière.
Et si on restait sur terre ?
Authors: Schultz Nikolaj
Published: November 2023

Cet article a d’abord été écrit pour une présentation lors de l’Aarhus Architecture Festival, à l’école d’architecture d’Aarhus, le 8 octobre 2021. Il a été légèrement édité, en conservant le rythme oral du texte. Il est actuellement en cours de développement pour un livre à paraître aux éditions de La Découverte en 2024, avec pour titre provisoire Le Nouvel exode.
Dans l’épaisse tresse rougeâtre
Authors: Tassel Clémence
Published: November 2023

À partir d’une ethnographie en ligne d’un forum et d’entretiens avec des professionnels de l’anticipation au moment de la pandémie de Covid-19, nous montrerons que les pratiques spéculatives peuvent être comprises comme un processus technique, une certaine manière d’agencer un collectif de personnes, des représentations du monde et des temporalités. Qu’elles soient « bricologiques » ou procèdent de protocoles précis, les activités futures centrées engendrent une multitude de projections d’à-venir, mettant ainsi en mouvement un récit commun toujours en train de se (re)faire. Finalement, c’est la catégorie même de futur qu’interrogent ces expériences de dialogue temporel entre des options politiques.
Y a-t-il un pilote dans le tramway ?
Authors: Darche Camille
Published: November 2023

On suit ici les membres du Comité national pilote d’éthique du numérique alors qu’ils observent minutieusement la course folle d’un tramway jeté à pleine vitesse sur les rails mouvants d’un monde changeant. Certains freinent, d’autres accélèrent puis, ensemble, font un pas de côté – tâchent de prédire la manière dont le surgissement de véhicules sans chauffeur pourrait transformer le monde, d’anticiper le récit que l’on fera du voyage, de raconter pourquoi ces engins auront existé. S’il n’est pas déjà passé par-dessus bord, le lecteur se demandera finalement, un peu essoufflé, quelle est la main qui actionne le levier et à qui il revient d’en décider.
Extase fiction
Authors: -h-
Published: November 2023

Ce texte est le récit d’une expérience collective du point de vue de ses auteurices. Il relate la création d’un club de pratiques des imaginaires en réaction à la formation d’une Red Team, composée d’auteurices de science-fiction, ayant pour objectif d’aider l’armée française à concevoir les menaces futures pour les intérêts de la France. Les membres de Chronotopium ne concevant pas les intérêts de l’État comme étant les leurs vont alors s’appliquer à concevoir l’imaginaire comme un outil, un muscle qu’il faut entraîner afin de pouvoir projeter et rendre tangibles des possibles qui épousent leurs aspirations propres.
Comme dans un vaisseau spatial
Authors: Obadia Lionel
Published: November 2023

La cité d’Auroville, située au Tamil Nadu (Inde du Sud), a été pensée dès sa création en 1968 comme une cité expérimentale, un « laboratoire à l’échelle de la planète » inspiré par la vision syncrétique du leader spirituel Sri Aurobindo Ghose. Mise en œuvre à partir des visions de sa compagne, Mira Alfassa, dite « la Mère », sa conception emprunta autant aux codes de l’aventure spatiale qu’à l’ésotérisme et à la géométrie sacrée, en particulier le Matrimandir (Temple de la Mère) dont l’architecte voulait que sa porte principale « s’ouvre comme dans un vaisseau spatial ». Subtil mariage rétrofuturiste, alliant émancipation et spiritualité, sur lequel cet article s’interroge.
HEART SOUND NOISE SEPARATION FROM LUNG SOUND BASED ON ENHANCED VARIATIONAL MODE DECOMPOSITION FOR DIAGNOSING PULMONARY DISEASES
Authors: Sangeetha B. , Periyasamy R.
Published: November 2023

Lung sound (LS) signals are vital for diagnosing pulmonary disorders. However, heart sound (HS) interferes with the analysis of LS, leading to the misdiagnosis of lung disorders. To address this issue, we propose an Enhanced Variational Mode Decomposition (E-VMD) technique to remove HS interference from LSs effectively. The E-VMD method automatically determines the mode number for signal decomposition based on the characteristics of variational mode functions (VMFs) such as normalized permutation entropy, kurtosis index, extreme frequency domain, and energy loss coefficient. The performance of the proposed denoising technique was evaluated using six performance metrics: Signal-to-noise ratio (SNR), root mean square error (RMSE), normalized mean absolute error (nMAE), correlation coefficient factor (CCF), CPU[Formula: see text], and CPU[Formula: see text]. In comparison to other denoising methods such as empirical mode decomposition (EMD), ensemble empirical mode decomposition (EEMD), complementary ensemble empirical mode decomposition (CEEMD), singular spectrum analysis (SSA), and variational mode decomposition (VMD), the new E-VMD method demonstrates superior denoising outcome. The proposed method was evaluated using LS recorded from the outpatient department of Thoracic Medicine at Thanjavur Medical College and Hospital, Thanjavur. The obtained performance measures are as follows: RMSE: 0.02103 ± 0.00054, SNR: 28.52464 ± 0.00253, nMAE: 0.00009 ± 0.00056, CCF: 0.9962, CPU[Formula: see text]: 34.586, and CPU[Formula: see text]: 0.452 s. These results affirm the adaptability and robustness of the proposed method, even in the existence of HS noise. This method improves denoising accuracy and computational efficacy, making it a useful tool for improving the analysis of LS signals and assisting in medical diagnostics. This technique utilizes an electronic stethoscope, a common clinical device used by healthcare professionals for detecting lung disease.
Pre-Service Teachers and Mathematics Writing
Authors: Smith R. Alex , Price Madeline Day , Arsenault Tessa L. , Powell Sarah R. , Smith Erin , Hebert Michael
Published: November 2023

This chapter focuses upon research related to building pre-service teachers' (PSTs') own competencies in mathematics writing (MW) as well as their skills in teaching MW and integrating MW into their future K-12 classrooms. The authors provide a review of the research with PSTs and MW. Although there is limited research on PSTs and MW, it is likely that many PSTs enter their preparatory programs with limited MW experience and competencies despite expressing beliefs in the value of MW. Therefore, there is a responsibility of mathematics teacher educators (MTEs) to build PSTs' knowledge of the various genres of MW and their purposes, to explicitly teach PSTs to compose high-quality MW themselves, and to provide frequent models of how MW may be integrated into the mathematics classroom across a range of genres. The authors conclude with suggestions for current practice and future research.
A metodologia antropofágica de Guimarães Rosa
Authors: Silva Míriam Cristina Carlos , De Castro da Silva Gustavo
Published: November 2023

Entendimento do método criativo de Guimarães Rosa a partir da definição de metodologia antropofágica em Oswald de Andrade. Após a análise de trabalhos anteriores acerca da antropofagia em Guimarães Rosa, relacionamos, criticamos e apontamos aspectos pouco considerados pela crítica, e presentes em sua biografia e criação literária. Nossa conclusão é a de que a teoria antropofágica foi pensada e praticada por Guimarães Rosa como método de trabalho artístico.
Antropofagia às avessas: modernismos e decolonialidade
Authors: Teixeira Maurício de Carvalho , Graeff Nina
Published: November 2023

Este texto de apresentação retoma os termos que originaram este dossiê, abarcando a ideia inicial da chamada de artigos que buscava ampliar os conceitos de modernismo e de decolonialidade em diferentes pesquisas. Posteriormente, realizou-se uma descrição avaliativa de cada um dos dez artigos que compõem o volume e da entrevista documental que o encerra. Ao se abrir para o inesperado, o dossiê reuniu contribuições de grande diversidade, atualizando as discussões sobre intersecções entre a produção modernista e a decolonial.
Expansion of the Innate Lymphocyte Family: Discovery of IL-22–Producing ILC3s
Authors: Choi Hee Sun , Kuchroo Vijay K
Published: November 2023

This Pillars of Immunology article is a commentary on “A human natural killer cell subset provides an innate source of IL-22 for mucosal immunity,” a pivotal article written by M. Cella, A. Fuchs, W. Vermi, F. Facchetti, K. Otero, J. K. M. Lennerz, J. M. Doherty, J. C. Mills, and M. Colonna, and published in Nature, in 2009. https://www.nature.com/articles/nature07537.
Correlation between extended surgical mask usage and adverse health effects during the COVID-19 pandemic among healthcare personnel in Jazan, Saudi Arabia
Authors: Ali Suhaila A. , Alqassim Ahmad Y. , Alshekh Fatmah O. , Alshammakhi Atheer M. , Omar Rawan N. , Areeshi Roaa A. , Alhazmi Roaa M. , Zaalah Lamees A. , Muaddi Mohammed A. , Alharbi Abdullah A.
Published: November 2023

The global prevalence of COVID-19 has necessitated the use of personal protective equipment, particularly face masks, amongst healthcare workers (HCWs). However, extended face mask usage has led to adverse health effects. This cross-sectional study investigates the relationship between prolonged surgical mask-wearing and the development of adverse effects among 500 HCWs in Jazan, Saudi Arabia. The study utilized an anonymous questionnaire distributed across multiple departments in Jazan and Sabya Hospitals. The results indicated that most participants believed that wearing face masks for extended periods led to adverse skin and respiratory effects. The primary respiratory complaints were difficulty breathing and nasal itching, while skin-related issues included sweating, itching, and acne. Therefore, this study concludes that extended surgical mask usage during the COVID-19 pandemic could potentially lead to adverse health implications among HCWs in Jazan. Further research into this correlation is needed.
Lakes in the Anthropocene: Reflections on Tracking Ecosystem Change in the Arctic
Authors: Guilizzoni Piero
Published: November 2023

This book - requested by S.J. Hawkins, the Editor of Excellence in Ecology, when John Smol was recognized with the International Ecology Institute Prize - is certainly one of the most modern and complete texts on the Canadian Arctic. The polar area like many other extreme environments that I studied during my scientific activity (e.g., Greenland, Antarctica, Svalbard archipelago, Finland Lapland and mountain ecosystems), has for years been subject to great alterations due to climate changes (“the big threat multiplier”), mine effluents, local and long-distance pollution. The book provides an excellent overview of how the arctic environment has developed during the last ca. 200 years and even before. The Arctic environment is transforming rapidly....
Antinociceptive and anti-inflammatory actions of curcumin and nano curcumin: a comparative study
Authors: Mohammadi Mojdeh , Abadi Farshid Sangin , Haddadi Rasool , Nili-Ahmadabadi Amir
Published: November 2023

Background and purpose:

Pain and inflammation can be treated by various therapies that for the most part are not effective and can result in adverse effects. The current study was proposed to compare the antinociceptive and anti-inflammatory actions of curcumin and nano curcumin in rats.

Experimental approach:

Rats were randomly allocated into ten groups of six for formalin and tail-flick tests including the control group, curcumin and nano curcumin groups (20, 50, 100 mg/kg), morphine group (10 mg/kg), naloxone + 100 mg/kg curcumin group, and naloxone + 100 mg/kg nano curcumin group. There were nine groups for the carrageenan test. Groups 1-7 were the same as the previous division; groups 8 and 9 received 10 mg/kg diclofenac and 1% carrageenan, respectively.

Findings/Results:

All doses of nano curcumin significantly decreased the paw-licking time in both phases of the formalin test. In the tail-flick test, curcumin 100, nano curcumin 100, naloxone + curcumin 100, and naloxone + nano curcumin 100 showed significant analgesic effects compared to the control group. In the paw edema test, at 180 s after injection, curcumin (50 and 100 mg/kg) and all doses of nano curcumin significantly inhibited carrageenan-induced edema. Myeloperoxidase activity and lipid peroxidation decreased at doses of 50 and 100 mg/kg of curcumin but at three doses of nano curcumin (20, 50, and 100 mg/kg).

Conclusion and implication:

In conclusion, our results suggest that the nanoemulsion formulation of curcumin can be efficient in reducing pain and especially inflammation in lower doses compared to the native form of curcumin.
Computational design of newly engineered DARPins as HER2 receptor inhibitors for breast cancer treatment
Authors: Isfahani Maryam Beheshti , Mahnam Karim , Seyedhosseini-Ghaheh Hooria , Sadeghi Hamid Mir Mohammad , Khanahmad Hossein , Akbari Vajihe , Varshosaz Jaleh
Published: November 2023

Background and purpose:

Human epidermal growth factor receptor 2 (HER2) is overexpressed in approximately 25% of breast cancer patients; therefore, its inhibition is a therapeutic target in cancer treatment.

Experimental approach:

In this study, two new variants of designed ankyrin repeat proteins (DARPins), designated EG3-1 and EG3-2, were designed to increase their affinity for HER2 receptors. To this end, DARPin G3 was selected as a template, and six-point mutations comprising Q26E, I32V, T49A, L53H, K101R, and G124V were created on its structure. Furthermore, the 3D structures were formed through homology modeling and evaluated using molecular dynamic simulation. Then, both structures were docked to the HER2 receptor using the HADDOCK web tool, followed by 100 ns of molecular dynamics simulation for both DARPins / HER2 complexes.

Findings/Results:

The theoretical result confirmed both structures' stability. Molecular dynamics simulations reveal that the applied mutations on DARPin EG3-2 significantly improve the receptor binding affinity of DARPin.

Conclusion and implications:

The computationally engineered DARPin EG3-2 in this study could provide a hit compound for the design of promising anticancer agents targeting HER2 receptors.