bluuebunny/crossref_metadata_2025 huggingface dataset:
Umbelliferone Enhances Immune Function in Cyclophosphamide-Induced Immunosuppressed Mice via Histidine and Purine Metabolism Regulation
Authors: Li Mei , Wang Jing , Huo Bingjie , Wan Qianqian , Xing Liwei , Wang Yuming , Pei Huan , Wang Li , Xia Yafei , Cui Huantian
Published: February 2025

Background:

Chemotherapy-induced immunosuppression significantly impacts patient’s quality of
life. Umbelliferone (UMB) is known for its anti-inflammatory, antioxidant, and anti-apoptotic properties, but
its effects on cyclophosphamide (CTX)-induced immunosuppression need further study.

Methods:

We established a CTX-induced immunosuppressed mouse model and administered varying doses of
UMB. Immune function was assessed by evaluating white blood cells, lymphocytes, thymus and spleen indices,
and CD4+/CD8+ T cell ratios. Serum levels of IL-2, IFN-γ, IgA, IgM, and IgG, along with macrophage
phagocytic activity, NK cytotoxicity, and lymphocyte proliferation, were measured. Untargeted metabolomics
was used to identify key pathways regulated by UMB, and RT-qPCR and Western blotting were performed to
analyze the expression of related enzymes and metabolites.

Results:

UMB intervention increased white blood cells, lymphocytes, thymus and spleen indices, and
CD4+/CD8+ T cell ratios in CTX-immunosuppressed mice. It reversed reduced levels of serum IL-2, IFN-γ,
IgA, IgM, and IgG and improved macrophage phagocytic activity, NK cytotoxicity, and lymphocyte proliferation.
Key pathways identified by metabolomics included histidine and purine metabolism. UMB improved levels
of histamine, L-glutamate, L-aspartate, xanthine, dAMP, deoxyinosine, xanthosine, and cGMP and upregulated
HDC, ASPA, and PNP while downregulating XDH, PDE5, ROS, and MDA in spleen tissue. UMB enhanced
SOD activity and GSH levels and reduced apoptosis, as indicated by lower TUNEL-positive expression.

Conclusion:

UMB enhanced immune function in CTX-immunosuppressed mice through the regulation of histidine
and purine metabolism, exhibiting antioxidant and anti-apoptotic effects. These findings highlight the
potential of UMB in mitigating immunosuppression.
Preclinical Pharmacology of CX1837, a High-Impact Ampakine with an
Improved Safety Margin: Implications for Treating Alzheimer’s Disease
and Ischemic Stroke
Authors: Radin Daniel P. , Zhong Sheng , Cerne Rok , Shoaib Mohammed , Smith Jodi L. , Witkin Jeffrey , Lippa Arnold
Published: February 2025

Introduction:

For over a decade, AMPA receptor allosteric potentiators (AMPAkines)
have shown significant effectiveness in multiple preclinical studies related to neurodegenerative
and psychiatric disorders underpinned by deficient excitatory synaptic activity. Despite promising
preclinical evidence, the clinical translation of AMPAkines has been slow due to the propensity of
some of these compounds to produce seizures at or around therapeutic doses.

Materials and: Methods:

The preclinical activity of the AMPAkine CX1837 is disclosed in the
current work.

Results:

CX1837 enhanced synaptic transmission in hippocampal slices in vitro and dose-dependently
enhanced long-term potentiation, which is believed to control memory consolidation.
CX1837 boosted performance in cognition tests, such as the novel object recognition test and the
win-shift radial arm maze. CX1837 also increased attentional functioning in the 5-choice serial reaction
time task involving rats. CX1837 produced positive preclinical effects at 0.01-1.0 mg/kg
dose and elicited epileptic effects at 10 mg/kg dose. Discussion: CX1837 has demonstrated to
have one of the largest safety margins to date in preclinical studies. Low doses of CX1837, which
produce acute increases in cognition, may potentially increase neurotrophins when given chronically.
This could slow the progression of Alzheimer’s disease and reverse deficits secondary to ischemic
stroke.

Conclusion:

Together, our findings highlight CX1837 as a potential candidate for clinical development
in order to treat multiple neurodegenerative and psychiatric disorders.
Prospective Memory in Mobile: Using Smartphone-Based Calendars to Rehabilitate Prospective Memory in Patients with Alzheimer’s Disease
Authors: El Haj Mohamad , Gallouj Karim , Antoine Pascal , Chapelet Guillaume
Published: February 2025

Introduction:

The rapid growth of mobile phone use and internet access among older
adults can provide valuable opportunities for clinicians and researchers to incorporate these technologies
into the memory rehabilitation of patients with Alzheimer’s disease (AD). Building on
this opportunity, previous research has used smartphone calendar applications to cue prospective
memory in patients with AD. However, in these studies, the calendar has been programmed to
send cues only about the time of prospective events.

Method:

We investigated the benefits of the smartphone calendar applications sending notifications
about both the time and location of the prospective events. We recruited two groups. In the
first group (time-and-location-cued group), we configured smartphone-based calendars to send notifications
about the time and location of prospective events, while in the second group (time-cued
group), we configured smartphone-based calendars to send notifications only about the time of
prospective events. In both groups, we invited patients to attend three prospective events per week
during a three-week period.

Results:

The results demonstrated fewer omissions in the time- and location-cued group than in
the time-cued group.

Conclusion:

Providing patients with AD with several contextual cues through smartphone-based
calendars may result in better prospective performance than providing them with only one contextual
cue.
Enhanced Efficacy of Radiation Therapy against Glioblastoma by Attenuated Salmonella Carrying Co-Expression Plasmids with siRNA-PD-L1 and Endostatin
Authors: Ji Yinghua , Guo Jiaming , Jiang Hanyu , Ren Weiwei , Geng Jiaxin , Lei Mengyu , Li Jiahang , Dang Peiyuan , Wang Yu , Chen Xin , Zhao Tiesuo , Lu Chengbiao , Jia Huijie , Yang Jin
Published: February 2025

Background:

Glioblastoma (GBM), a common type of brain tumor, is currently treatable through radiation therapy. However, there is room for improvement in the effec-tiveness of treatment. Radiation can lead to an increase in the expression of PD-L1 and VEGF, which might reduce the responsiveness of the tumor to the therapy. This situation underlines the necessity for innovative treatment strategies.

Objectives:

In this study, we investigated the potential of attenuated Salmonella carrying the co-expressing plasmid siPD-L1-Endo to effectively inhibit PD-L1 and VEGF expres-sion, thereby enhancing the anti-tumor effects of radiation therapy in GBM-bearing mice.

Methods:

The regulatory mechanisms responsible for the treatment effect were detected by Flow cytometry, Immunohistochemistry, TUNEL, Immunofluorescence, H&E staining, and Western blot assays.

Results:

Upon administration of attenuated Salmonella carrying siRNA-PD-L1 and co-expressing endostatin plasmids, the results exhibited significant suppression of tumor growth and tumor cell proliferation, as well as a concurrent decrease in PD-L1 and VEGF expression in tumor tissues. Moreover, the treatment led to reduced expression levels of tumor-related proteins p-Stat3, MMP2, Cyclin D1, and PCNA, an increase in the expres-sion of the apoptosis-related protein cleaved-caspase3, facilitated infiltration of CD4+ and CD8+ T cells within tumor tissues, and an elevation of the ratios of CD4+, CD8+ T cells, and NK cells in the spleen of tumor-bearing mice.

Conclusion:

These findings highlight the ability of attenuated Salmonella carrying siR-NA-PD-L1 and co-expressing endostatin plasmids to effectively modulate PD-L1 and VEGF expression, thus strengthening the anti-tumor immune response in GBM-bearing mice subjected to radiation therapy. This combination therapy approach holds promise as a potential avenue for improving the efficacy of radiation therapy in the treatment of glio-blastoma.
Effects of Physical Exercise and the Use of Doxorubicin on Cardiac Function in Rodents: A Systematic Review and Meta-Analysis
Authors: Linhares Bruno Gama , Linhares Diego Gama , Vale Rodrigo Gomes de Souza
Published: February 2025

Background:

Anthracycline-based chemotherapy, such as Doxorubicin (DOX), often
induces cardiotoxicity in cancer patients, which compromises their health and quality of life.

Objective:

This study aimed to verify the effects of exercise concomitant with prolonged administration
of DOX on improving cardiotoxicity.

Methods:

A systematic literature search in MedLine, PubMed, Web of Science, and Scopus databases
was performed from inception until November 2023, strictly following the Preferred Reporting
Items for Systematic reviews and Meta-Analyses (PRISMA) statement. Preclinical randomized
controlled trials related to exercise, cardiotoxicity, and DOX were included.

Results:

Eight studies were included in the systematic review and 7 were selected for metaanalysis. By evaluating the Fractional Shortening (FS), it was possible to verify that exercise as complementary therapy provided a cardioprotective effect when compared to DOX combined with sedentary behavior (heterogeneity: I² = 53%; tau² = 0.19; p = 0.03; overall effect: z = 2.69; p < 0.01). However, no additional benefits were observed for the Left Ventricular Ejection Fraction (LVEF) (heterogeneity: I² = 82%; tau² = 1.43; p < 0.01; overall effect: z = 1.42; p = 0.15).

Conclusion:

The included studies demonstrated exercise to have a cardioprotective effect on rodents,
mainly on FS. However, there is a lack of high-level evidence to guide exercise prescription
in clinical practice to improve cardiotoxicity associated with DOX administration.
Integrative Multi-Omics Approaches for Personalized Medicine and Health
Authors: Tiwari Prateek , Pandey Raghvendra , Chadha Sonia
Published: February 2025

Introduction:

Multi-omics data integration has transformed personalized medicine,
providing a comprehensive understanding of disease mechanisms and informed precision therapeutic
options. Multi-omics data generated for the same samples/patients can help in getting insights into
the flow of biological information at several levels, thereby providing in-depth information regarding
the molecular mechanisms underlying pathological conditions. Multi-omics integration
plays a pivotal role in personalized medicine by providing comprehensive insights into the complex
biological systems of individual patients. This review provides a comprehensive account of the current
and future progress brought into multi-omics methodologies, promising to refine diagnostics
and therapeutic strategy by integrating genomic, transcriptomic analyses, proteomics approaches
and metabolome screens.

Methods:

A literature search was performed in PubMed using keywords like genomics, proteomics,
transcriptomics, metabolomics, multi-omics, and precision medicine to identify published research
articles. A thorough review of all results was then conducted, and their results and conclusions were
compiled and summarized.

Result:

By analyzing various omics layers, such as genomics, transcriptomics, proteomics, and
metabolomics, multi-omics approaches enable the identification of patient-specific molecular traits
and the discovery of new clinical therapeutics for diseases. Integration of various data types augments
diagnostics, optimizes therapeutic regimens and supports personalized medicine according to
an individual patient profile.

Conclusion:

Integration of multi-omics data and its applications in various fields, such as cancer research,
helps in optimizing patient-specific treatment and improvement of patient health. With time,
as these technologies reach more people, they stand to democratize precision medicine and hopefully
bridge health disparities. In conclusion, the present review highlights multiomics data integration
as a transformative step towards personalized medicine and ultimately changing patient care from
empirical-based to precision or individualized.
Virtual Screening and Biological Evaluation of T22306 as a Potent Third-generation EGFR Inhibitor for NSCLC Treatment
Authors: Wang Ran , Ruan Wei , Fan Dang , Long Li , Zhang Han , Li Min , Xu Shan , Wang Linxiao
Published: February 2025

Objectives:

According to the data, mutations in EGFR-related genes are the main cause of Non-Small
Cell Lung Cancer (NSCLC), necessitating the development of new drug constructs for EGFR-TKIs particularly
important. This study aimed to screen potential third-generation EGFR-TKIs to address the emerging drug resistance
challenges in NSCLC.

Methods:

In this study, virtual screening, molecular dynamics modeling, and bioactivity evaluation were carried
out to find a potential EGFR inhibitor that could overcome the L858R/T790M mutation. At first, 12 potential
compounds were screened step by step from about 250,000 structures by virtual screening. These 12 compounds
were subjected to MTT antitumor activity evaluation and kinase inhibition assay to select compounds with strong
antiproliferative effects on cancer cells. Then, the preferred compounds were subjected to time-dependent assay,
scratch assay, AO staining assay, and hemolysis assay. Finally, the preferred compound was subjected to molecular
docking and molecular dynamics simulation with 5HG7 protein.

Result:

The IC50 of T22306 on H1975 cells was 9.17 μM. In further kinase evaluation, the kinase inhibition of
EGFRL858R/T790M was 69.17%. In addition, time-dependent experiments and scratch and AO staining assays
confirmed the potential of T22306 as an EGFR-TKI inhibitor, while hemolysis assays demonstrated no significant
toxicity. Finally, molecular docking revealed the formation of critical hydrogen bonds between T22306 and
LEU-718. Furthermore, molecular dynamics simulations showed that the T22306-5HG7 complex has a low binding
energy (-117.73 ± 18.69 kJ/mol), thus suggesting that T22306 binds tightly to the target protein 5HG7.

Conclusion:

In this study, we rapidly screened potential compounds against NSCLC with the help of virtual
screening technology. Further in vitro experiments demonstrated that T22306 successfully overcame the
L858R/T790M mutation and could be a potential epidermal growth factor receptor inhibitor.

result:

The IC50 of T22306 on H1975 cells was 9.17 μM. In further kinase evaluation, the kinase inhibition of EGFRL858R/T790M was 69.17%. In addition, Time-dependent, Scratch and AO staining assays confirmed the potential of compound T22306 as an EGFR-TKI inhibitor, while Hemolysis assays showed no significant toxicity. Finally, molecular docking revealed the formation of a critical hydrogen bond between compound T22306 and the 5HG7 protein, while the T22306-5HG7 complex was shown in molecular dynamics simulations to have a low binding energy (-117.728 ± 18.688 kJ/mol), thus suggesting that T22306 binds tightly to the target protein 5HG7.
Barbigerone against Lipopolysaccharide-Induced Memory Deficit in Rodents via Alteration of Inflammatory and Oxidative Stress Pathway: In vivo and Molecular Dynamics Simulations Study
Authors: Nadeem Muhammad Shahid , Khan Jalaluddin Azam , Al-Abbasi Fahad A. , Alqurashi May M. , Bawadood Azizah Salim , Alzarea Sami I. , Sayyed Nadeem , Gupta Gaurav , Kazmi Imran
Published: February 2025

Background:

Memory loss and cognitive decline are prominent symptoms of various
neurodegenerative diseases, impacting daily activities and posing a significant burden on healthcare
systems. The study aimed to explore the effect of barbigerone against LPS-induced memory impairment
in rats and may offer novel therapeutics for neurodegenerative diseases.

Methods:

A total of 30 male Wistar rats were utilized and subsequently divided into five distinct
experimental groups: group I received saline water as a control, group II- received LPS, group III -
received LPS, and barbigerone (10 mg/kg/p.o.), group IV- received LPS and a higher dose of
barbigerone (20 mg/kg/p.o.), and group V -barbigerone alone (20 mg/kg/p.o.). Behavioural test was
performed through the Morris water maze and Y-maze test. Biochemical markers such as oxidative,
proinflammatory, apoptotic, and further molecular docking and simulations elucidate the mechanisms
of barbigerone effects.

Results:

Barbigerone significantly improved the learning capacity of rats in both the MWM and Ymaze
tests, indicating enhanced memory and reduced latency times. Furthermore, barbigerone exhibited
beneficial effects on oxidative stress and inflammation markers, suggesting its potential to
protect against neuronal damage and promote cognitive function. Based on molecular docking,
barbigerone showed a greater binding affinity with different intermolecular interactions; among
them, NF-KB (ISVC) had the most potent interaction. Molecular dynamics simulations were performed
to assess the stability and convergence of complexes formed by Barbigerone with 1NME_
Barbigerone, 1SVC_Barbigerone, and 4AQ3 4AQ3_Barbigerone.

Conclusion:

These findings demonstrate that barbigerone possesses neuronal protective effects against
LPS-induced memory deficits in rats by restoring endogenous antioxidant and pro-inflammatory cytokines.

result:

The outcomes of this investigation revealed that the treatment of barbigerone significantly improved the learning capacity of rats in both the MWM and Y-maze tests, indicating enhanced memory and reduced latency times. Furthermore, barbigerone exhibited beneficial effects on oxidative stress and inflammation markers, suggesting its potential to protect against neuronal damage and promote cognitive function.
Computational Design of Multitargeted Ligands to Counter Drug Resistance of Mycobacterium Tuberculosis
Authors: Vummidi Varalakshmi , Talluri Sekhar
Published: February 2025

Background

Tuberculosis (TB) is a significant global health challenge due to drug resistance. Furthermore, tuberculous meningitis (TBM), which affects the central nervous system, has a particularly high mortality rate. TBM drugs have low efficacy because of their low blood-brain barrier (BBB) permeability. Many institutions that treat tuberculosis lack the infrastructure to identify specific drug-resistance mutations. The development of drugs with the capability of treating multiple strains would contribute considerably to the advancement of TB control in countries with limited resources. Therefore, there is an urgent requirement for novel therapeutics that can target native and drug-resistant strains.

Objective

This study aimed to design a novel drug to target native as well as drug-resistant Mycobacterium tuberculosis (MTB) strains associated with pulmonary TB and TBM.

Methods

RNA Polymerase beta-subunit (rpoB) was chosen because it is a validated target for MTB. Pharmacophore features, core moiety analysis, and docking scores were used for ligand screening. Deep neural networks (DeepFrag) were used for structural optimization, and binding affinity was evaluated using AutoDock Vina. Custom scoring schemes, STWMM for TB and STWMMM for TBM, met the requirements of high binding affinity for multiple targets, optimal pharmacokinetic profiles, and chemical synthesizability.

Results

M1, M2, and M3 were the molecules with the highest STWMM and STWMMM scores, indicating their potential for TB and TBM therapy. The average binding energy of M1 was -8.83 kcal/mol for native and mutant rpoB. The average binding energy for M2 and M3 was -9.63 and -9.83 kcal/mol, respectively).

Conclusion

In this study, novel ligands for native and drug-resistant TB and TBM therapy were obtained by multi-target drug design. A major challenge for current therapeutic regimens for TB and TBM is the rise of drug-resistant strains of Mycobacterium tuberculosis and the necessity of distinguishing them from the native strains. The multi-targeted ligands developed have the potential to overcome these limitations.
Práticas poéticas indígenas no período da invasão do Brasil à invasão dos sertões do Nordeste brasileiro
Authors: Campos Lindoaldo
Published: February 2025

Poetry was a strategy of resistance and social prominence used by the indigenous people of the backlands of the brazilian Northeast who survived the “War of the Barbarians” (which occurred between the end of the 17th century and the beginning of the 18th century), in a movement that, from the 19th century and alongside íbero-arabic poetry, it shaped the Sertão da Poesia, a way of life centralized by the municipalities of Teixeira/PB and São José do Egito/PE, where the Xukuru indigenous people historically lived. This article consists of a slightly modified version of an excerpt from Chapter 3 – Cowboys and Singers: Xukuru Poets Creating the Backland of Poetry, from the book Maracá, Gibão e Viola, which attempts to highlight aspects of indigenous poetry recorded from the 16th century to the 19th century, as a way of contributing to an approach to this theme.
Changes in Internet Activities and Influencing Factors for Problematic Internet Use During the COVID-19 Pandemic in Korean Adolescents: Repeated Cross-Sectional Study
Authors: Kim Sol I , Jin Jae-Chan , Yoo Seo-Koo , Han Doug Hyun
Published: February 2025

Background

As adolescents increasingly engage with digital experiences, the internet serves as a platform for social interaction, entertainment, and learning. The COVID-19 pandemic accelerated this trend, with remote learning and restricted physical interactions driving changes in internet behavior. Adolescents spent more time on gaming and social media, reflecting a notable shift in use patterns.

Objective

We hypothesized that the COVID-19 pandemic changed internet use patterns among Korean adolescents, including content types, time spent on web-based activities, and pathological use prevalence. Additionally, we anticipated that these changes would correlate with shifts in adolescents’ psychological status during the pandemic.

Methods

Data from 827 adolescents aged 12 to 15 years (n=144 in 2018, n=142 in 2019, n=126 in 2020, n=130 in 2021, n=143 in 2022, and n=142 in 2023) were gathered over 6 years from 43 middle schools across 16 regions and 1 hospital in South Korea. The demographic data collected included age, sex, and school year. Participants also provided information on their internet use patterns and levels of internet addiction. Additionally, psychological status, including mood, anxiety, attention, and self-esteem, was assessed.

Results

There were significant differences in the depression scale (Patient Health Questionnaire 9). The Patient Health Questionnaire 9 scores for 2018, 2019, and 2023 decreased compared to those in 2020, 2021, and 2022 (F5=3.07; P=.007). Regarding changes in internet use behavior, game playing among adolescents decreased after the pandemic compared to before, while watching videos increased. Additionally, the rate of problematic internet use was highest for games before COVID-19, but after COVID-19, it was highest for videos, and this trend continued until 2023 (χ23=8.16, P=.04). Furthermore, this study showed that the Young’s Internet Addiction Scale (YIAS) score was highest in the game group in 2018 compared to other groups before COVID-19 (F5=14.63; P<.001). In 2019, both the game and video groups had higher YIAS scores than other groups (F5=9.37; P<.001), and by 2022, the YIAS scores among the game, video, and Social Network Service groups did not differ significantly. The degree of influence on the severity of internet addiction was also greatest for games before COVID-19, but after COVID-19, the effect was greater for videos than for games.

Conclusions

During the COVID-19 pandemic, internet use for academic and commercial purposes, including remote classes and videoconferences, increased rapidly worldwide, leading to a significant rise in overall internet use time. The demand for and dependence on digital platforms is expected to grow even further in the coming era. Until now, concerns have primarily focused on the use of games, but it is now necessary to consider what types of internet behaviors cause problems and how to address them.
Building a Smart Hospital System Through Ward Automation at the National Health Insurance Service Ilsan Hospital (Preprint)
Authors: OH Jun Hee , Park Young Min , Park Min Hyun , Han Jung Mi , OH Seung Jin , Kim Jung A , KIM JOO YOUN , PAK HAEYONG
Published: February 2025

BACKGROUND

This study presents the development of a smart hospital system through implementation of ward automation at the National Health Insurance Service (NHIS) Ilsan Hospital. The primary goal is to share our experience and provide foundational knowledge for other healthcare institutions that want to establish similar smart hospital systems. The ward automation system operates on a Bluetooth-enabled wireless network, with more than 1,000 signal scanners installed throughout the hospital.

OBJECTIVE

The scanners collect data from various smart devices and transmit them to the hospital information system. Additionally, a dedicated Internet of Medical Things monitoring platform is used to visualize the gathered data and manage various medical devices

METHODS

The ward automation solutions focus on two primary areas: automatic transfer of vital signs to electronic medical records (EMR) and real-time remote monitoring

RESULTS

By automating the transfer of blood pressure, body temperature, height, and weight directly to the EMR, the system reduces manual input and minimizes the risk of errors. Real-time remote monitoring includes functions such as tracking medical assets and high-risk patients, monitoring refrigerator temperatures, tracking infusion rates, and a psychiatry-specific system for monitoring risk of self-harm risks

CONCLUSIONS

This system enhances data accuracy, improves healthcare staff efficiency, and strengthens patient safety management. Ensuring a stable network environment and consistent maintenance is essential for successful implementation. This case study demonstrates the potential of ward automation systems to advance healthcare delivery, with future work focusing on integrating innovative smart solutions, incorporating user feedback, and establishing a dedicated department for system maintenance and improvements
The Role of the School Principal in the Design of Learning Spaces and the Evaluation of Inclusion
Authors:   Dottore di Ricerca, Universita di Salerno, Italy, Formisano Maria Anna , Brenca Rita ,   Dirigente Scolastico, Ministry of Education and Merit, Italy
Published: February 2025

This paper explores the vital role of school principals in the design of learning spaces and the
evaluation of inclusion within educational environments. Recognizing the significant relationship
between architecture and pedagogy, it articulates how principals can promote inclusive
education by establishing and maintaining learning spaces that are accessible, flexible, and
conducive to diverse learning needs. By collaborating with educational stakeholders and
employing innovation in teaching practices, principals can create learning ecosystems that
prioritize the well-being and success of all students. The paper also emphasizes the importance
of evaluating inclusive practices through self-assessment tools, such as the Self-Evaluation
Report (RAV), to identify strengths and address areas for improvement in fostering an inclusive
educational atmosphere. Ultimately, it posits that effective school leadership is instrumental in
advancing a culture of inclusion, benefiting not only the academic but also the social and
emotional development of every student.
Educational Innovation in the Wake of COVID-19: Directions and Challenges
Authors:   Andong National University, Andong City, North Gyeongsang Province, South Korea  D, Kim Bok-rae
Published: February 2025

In recent years, society has experienced significant shifts due to the COVID-19 pandemic, the
widespread adoption of social distancing, and the rise of the contact-free (untact) economy.
These changes have driven an accelerated digital transformation, profoundly impacting various
sectors, particularly education. Governments and educational institutions were compelled to
rapidly implement new infrastructures, curricula, and teaching methods to support non-face-toface learning. Additionally, the advent of generative artificial intelligence (AI) technologies, such
as ChatGPT, is disrupting traditional educational models, shifting the focus of education from
knowledge acquisition to adaptability and innovation. Achieving sustainable educational
innovation now requires not only the integration of advanced technologies but also a
comprehensive rethinking of curricula, learning environments, and educational practices. This
paper examines the challenges and future directions in fostering meaningful educational
innovation, emphasizing the critical role of educators and practitioners in this transformation. As
lifelong learning becomes increasingly relevant, education is evolving beyond college preparation
to support personal growth, leisure, and employment, positioning it as a dynamic contributor to
future societal and economic development.
Application of Information Technology in Identifying HOAX Information Circulating on Social Media Related to the COVID-19 Pandemic by the Sawahlunto Police Cyber Patrol Team
Authors: Pinandhita Johannes Bregas , S. Basir , Prianggono Jarot
Published: February 2025

The COVID-19 pandemic in the era of Industry 4.0 has fueled the spread of misinformation and disinformation on social media. Unregulated discussions and the 24-hour news cycle have facilitated HOAXes, often aimed at inciting public unrest. This phenomenon has led to a lack of trust in the validity of Covid-19 information, contributing to the rise in cases. Consequently, the government cannot address this issue alone and requires support from law enforcement. This study examines the problem from a police science perspective, proposing digital policing (e-policing) as a solution to identify and address circulating HOAXes. The Indonesian National Police's Priority Program (PRESISI) outlines an innovative approach by introducing the Polisinyo Urang Sawahlunto (PUAS) application. This research uses a qualitative approach to analyse the relevant findings, including interviews, observations, and literature reviews. The results show that: 1) The spread of HOAX information via social media within the Sawahlunto Police's jurisdiction is still widespread; 2) The PUAS application's HOAX checker feature can identify HOAXes related to COVID-19, helping the police gather valid information to share with the public; 3) However, when analysed through management theory, the application's implementation still lacks fulfilment of the Man, Money, Method, and Machines components. As a result, PUAS has not yet been fully implemented and requires further development.
Фактори впливу на ефективність антикризових PR-кампаній Factors influencing the effectiveness of a crisis PR campaign
Authors: Dankeieva Oksana , Zakrevska Lyudmila
Published: February 2025

This research aims to identify and characterise key influencing factors that impact the effectiveness of crisis communication campaigns. This study has identified and characterised key factors influencing the effectiveness of crisis communication campaigns, namely the speed of the company's response to a crisis, clearly defined roles and responsibilities of the company's crisis management team, the nature of the crisis, understanding public sentiment, and the choice of communication channels. Factors influencing the presence of a crisis management team within a company have been characterised. This study has shown that a company's consideration of the nature of a crisis will impact the definition of the crisis communication campaign's objectives, understanding of stakeholder needs, and considering their specific characteristics and values when conveying messages into the information space, which will facilitate the application of appropriate crisis communication measures to achieve the stated goal. It has been determined that understanding public sentiment will enable companies to employ crisis communication tools that can effectively shape public opinion regarding the company's crisis and/or influence its trajectory. The importance of selecting communication channels for crisis communication campaigns has been substantiated, as each audience has its specific communication channels that depend on the speed of information delivery, the level of trust in communication channels, the interaction of communication channels, and other factors.The conducted research has demonstrated the importance of considering factors influencing the effectiveness of crisis communication campaigns for modern companies that constantly face the threat of crises in their operations. Understanding the specific characteristics of factors affecting the effectiveness of crisis communication campaigns will not only enable the minimisation of negative consequences of a situation but also provide opportunities for the company's growth and resilience.
The Standardized Data Management Plan for Educational Research
Authors: Netscher Sebastian , Kaluza Harald , Mauer Reiner , Mozygemba Kati , Stephan Karsten
Published: February 2025

Although there is an increasing number of tools and support opportunities, research data management is still challenging. Conventional templates of data management plans (DMP) guide users, but hardly support them in implementing and realizing data management. Instead, users of conventional templates require more tailored guidance to better understand how to manage their data according to the needs of their research discipline, and its methods and practises, e.g., regarding data sharing. To provide more tailored, discipline-specific guidance, Science Europe (2018) suggests developing and using so-called Domain Data Protocols, i.e., a model DMP for a given discipline or community. The project Domain Data Protocols for Empirical Educational Research was one of the first to turn this concept into a practically useable DMP template tailored to educational research by developing the Standardised Data Management Plan for Educational Research (Stamp). The Stamp is designed to assist researchers in managing their data, appropriately, and to ensure shareable data according to the FAIR Data Principles. Due to its flexible structure, its checklist and auxiliary materials, the Stamp tackles most of the challenges of conventional DMP templates. Providing tailored, discipline-specific guidance and enabling to manage various types of data, the Stamp is an innovative approach to further professionalize data management.
Initial Effects of Clearcutting and Partial Retention Forest Harvesting Methods on Some Small Mammals in Northern British Columbia
Authors: Constantinou Alexia , Burton A Cole , Simard Suzanne , Hodder Dexter
Published: February 2025

British Columbia’s interior forests have been heavily subjected to logging, burning, and beetle outbreaks for decades. Partial retention forest harvesting may be a method that could mitigate some of the negative effects of clearcut harvesting on wildlife. We conducted live trapping for small mammals at John Prince Research Forest in north-central BC to estimate species diversity, population density, and habitat use across a gradient of overstory tree retention. We detected 7 species, with diversity highest in the uncut forest (control) relative to the clearcut (control mean Shannon Index = 1.01, SE = 0.14) and partial retention treatments (30% and 60% retention, mean Shannon Indices = 0.99, 0.98; SE = 0.17, 0.17), and significantly lower in the seed tree treatment (mean = 0.63, SE = 0.17, p = 0.02). Greater population densities of North American deer mouse (Peromyscus sonoriensis) and southern red-backed vole (Myodes gapperi) in partially harvested stands, as estimated with spatially explicit capture-recapture models, support these practices for supporting populations of forest specialists. More experimental approaches to forest operations are needed across larger spatial scales, such as adaptive management of forest harvest methods with rigorous wildlife monitoring to ensure ecological objectives are met.
THE USE OF THE INSTITUTION OF RESIDENCE IN SOCIAL SECURITY RELATIONS
Authors:   Bryansk State Academician I.G. Petrovski University, Rodina Tatyana , Kozin Dmitriy ,   Bryansk State Academician I.G. Petrovski University
Published: February 2025

The article analyzes the practice of applying the institution of residence in social security relations, and notes the lack of a uniform approach to understanding the criteria for providing social support measures, including the place of residence. The author proposes to reformulate the principle of prohibiting the conditionality of rights by the place of registration in the law on freedom of movement, as well as to supplement the legislation of social security, indicating that the basis for granting measures is the existence of status, and the conditions for their provision are determined by law
viaje multiespecie: animales de compañía y evolución familiar desde una perspectiva de trayectoria vital
Authors: López-Cepero-Borrego Javier , Español Alicia , Rodríguez Banda Ángel
Published: February 2025

El presente estudio analiza el papel de los animales de compañía en el curso de vida de la familia. Utiliza para ello un enfoque evolutivo, conceptualizando el vínculo entre especies como una intersección de trayectorias vitales de animales humanos y no humanos. Se llevaron a cabo tres grupos focales en línea y se realizó un análisis temático utilizando una perspectiva vivencial y constructivista. Los cuatro temas extraídos hacen referencia a momentos de convivencia: 1) la llegada del animal, 2) la maduración conjunta de la relación, 3) los cambios relacionados con las transiciones familiares, y 4) el final de la relación. Estos temas describen cómo la individualidad de los animales de compañía y la identidad de la familia coevolucionan a lo largo del curso de la vida y ponen de relieve los retos a los que se enfrentan las familias. Estos hallazgos contribuyen a la literatura que cuestiona los discursos sociales dominantes y muestran modelos emergentes de familias multiespecies.
Larissa Buchholz: The Global Rules of Art. The Emergence and Divisions of a Cultural World Economy. Princeton University Press, 2022
Authors: Guirao Soro Gloria
Published: February 2025

La globalización del arte no es un fenómeno nuevo: la circulación de obras de arte y de artistas es una constante histórica. Sin embargo, el canon artístico ha estado formado principalmente por artistas europeos y americanos hasta la década de 1980. Se puede hablar de un “campo global” del arte desde entonces, partiendo de una serie de indicadores de globalización que incluye la emergencia de bienales y la expansión del mercado artístico fuera de Occidente, así como un discurso y unas problemáticas transnacionales del arte. En The Global Rules of Art. The Emergence and Divisions of a Cultural World Economy, Buchholz propone una aproximación a la valuación del arte a partir del modelo de la economía dual de los bienes simbólicos de Pierre Bourdieu expandido al contexto global. Su propuesta tiene en cuenta tanto lo común como lo distintivo de las culturas globalizadas, buscando evaluar las desigualdades estructurales y los significados que las definen.
A Power-Efficient Optical Modem for Reliable, Long-Distance Communication Using GFDM Technology in Underwater and Terrestrial Wireless Systems
Authors: Tejovathi VENATI  , Swarnalatha SUGALI
Published: February 2025

This paper presents the design of a GFDM-based optical communication modem using MATLAB SIMULINK to improve the power efficiency, reliability and long distance communication in underwater wireless communication (UWC) systems. Conventional techniques such as orthogonal frequency division multiplexing (OFDM) and single-carrier frequency division multiple access (SC-FDMA) are commonly utilized to enhance data rates, reduce BER, and mitigate the impact of multipath fading. However, these methods come with certain limitations. OFDM, for instance, suffers from a high peak-to-average power ratio (PAPR) and significant out-of-band emissions, whereas SC-FDMA is highly susceptible to inter-symbol interference (ISI) in multipath environments. Generalized frequency division multiplexing (GFDM) provides a better flexibility for reducing the PAPR and improve the robustness against Doppler effects of a critical factor in UWC by using non-orthogonal subcarriers. By using MATLAB SIMULINK, the optical communication modem was developed for long distance signal transmission and reception. This approach enhances channel bandwidth utilization and spatial diversity, making it a more effective solution for underwater wireless communication. As a result, GFDM emerges as a promising alternative to conventional techniques, offering improved modem performance by reducing bit error rate (BER), increasing spectral efficiency, and demonstrating greater resilience to variations in underwater channel conditions.
Strengthening Religious Moderation in Social Media to Fight Online Radicalism
Authors: Daud Sulhi Muhammad , Bafadhal M. Iqbal
Published: February 2025

The aim of this research is to explore how efforts to strengthen religious moderation on social media can eradicate online radicalism. The author uses the Maudhu'i exegesis method, namely raising one topic then selecting several verses and hadiths related to religious moderation then connecting them with developments in technology, the internet and social media. The research results show that the use of counter-narrative material on social media will encourage religious moderation, tolerance, a spirit of pluralism, harmony and peace, so that the phenomenon of online radicalism can actually still be resisted by the younger generation. The way to do this is by strengthening religious moderation on social media such as; social media campaigns accompanied by collaboration with influencers, preaching religious moderation through podcasts, and creating innovative playstore-based religious moderation applications on smartphones.
Hidden Curriculum Model: PAI Tutorial Program Collaboration in Building Religious Digital Literacy Awareness at Jambi University
Authors: Iryani Eva , Sobri Muhammad , Hasibuan Tuti Hardianti
Published: February 2025

This study aims to provide an in-depth description of the phenomenon of implementing the hidden curriculum in collaborative learning of the Pai Tutorial Program in Building Awareness of Religious Digital Literacy at Jambi University. The main focus of this research approach is qualitative research. as quoted by Creswell Qualitative is a research approach that aims to understand what phenomena are presented by research topics such as behavior, perceptions, motives, and actions and others. Qualitative Approach This study aims to reveal data in related fields: Hidden Curriculum Model in the PAI Tutorial Program in building awareness of religious digital literacy and its application. As well as looking at the perceptions of students who take part in the tutorial program with the Hidden Curriculum model of digital literacy collaborative learning at the University of Jambi. The hidden curriculum is an invisible curriculum, can occur spontaneously, unplanned and can arise from learning experiences in schools. Even though the hidden curriculum does not have formal and measurable systematics, it plays a very important role in realizing a learning goal, especially PAI learning. PAI learning can be achieved optimally with hidden curriculum support through tutorial activities involving students outside class hours
Pendekatan Spiritualitas Untuk Kebermaknaan Hidup Penderita Hipertensi
Authors: Pambuka Fian Rizkyan Surya , Rahmadi Sidiq , Hidayat Wahyu , Saputra Tri Danang Nugroho Ikhwan , Alamsyah Muawwalul Bahafi
Published: February 2025

Hipertensi merupakan penyakit kronis yang  menjadi penyebab primer penyakit kronis yang lain. Penyakit hipertensi termasuk penyakit yang hanya dapat ditangani dengan obat-obatan dan modifikasi perilaku. Akantetapi, individu dengan penyakit kronis juga sering mengalami pandangan hidup yang pesimis hingga muncul kecemasan, dan kekhawatiran. Memberi makna dalam hidup dapat mendukung spiritualitas inividu. Maka tujuan dari penelitian ini adalah menjelaskan pentingnya spiritualitas untuk kebermaknaan hidup. Metode yang digunakan adalah literatir riview, peneliti melakukan pencarian artikel terkait menggunakan. Melalui penelitian ini dijelaskan bahwa spiritualitas menjadi aspek pendukung dan pelengkap pengobatan maupun terapi sbelumnya.
The Impact of Online Games on Student’s Religiosity
Authors: Maharani Chehra Nabilah
Published: February 2025

This research aims to gather sufficient information about the impact of online gaming on the religiosity of university students. This research method is a literature study that collects several previous studies to answer the impact of online games on a person's religiosity, especially a student. The results of this study indicate that there are changes regarding decreasing someone's religiosity caused by an addiction to playing online games, which results in negligence in performing obligations as Muslims. The suggestions given are to develop strategies to reduce the negative impact of online games, such as paying attention to playing time according to obligations and needs and using online games as a tool to build abstract thinking skills.
Gen Z's View on Islam and People's Welfare
Authors: Hanifah Khansa , Sobri Muhammad
Published: February 2025

This research aims to provide comprehensive insights to policymakers, educators, and religious communities. This research uses a qualitative approach method with a literature review. The results of this research show that Generation Z's views on Islam in the 13-26 year age range are influenced by various factors, including the environment, media, and personal experience. It is essential to acknowledge this diversity of views and encourage open dialogue and mutual understanding among members of Generation Z to understand and respect differences. Through a literature review, I analyze Generation Z's religious perceptions, knowledge, and practices and their impact on individual and societal well-being.  My results reveal the complexity of the interactions between religious values, social values, and personal aspirations in shaping Gen Z's perspective on Islam and the well-being of the Ummah, providing important insights for further understanding religious dynamics in the digital and globalization era.
Technological Innovation in the Islamic World: History and Today's Challenges
Authors: Yoza Alifa Putri
Published: February 2025

In a modern era filled with rapid technological development, the Islamic world faces a number of challenges in technological development. Key factors influencing this advancement are education, economics, and globalization. First, quality education becomes an important foundation in preparing individuals to contribute to technological innovation. However, there are still gaps in access to and quality of education in various Islamic countries. Second, economic challenges include dependence on natural resources and lack of investment in research and development. A greater boost is needed to strengthen the knowledge-based sector of the economy. Third, globalization affects how technology is developed and deployed, while there are still barriers to access and digital infrastructure. International cooperation and investment in internet connectivity are key to overcoming these challenges. By focusing on collaboration, investment, and renewal, the Islamic world can transcend these challenges and become a leader in global technological innovation