bluuebunny/crossref_metadata_2025 huggingface dataset:
Distribution of wealth-stratified inequalities on maternal and child health parameters and influences of maternal-related factors on improvements in child health survival rate in Bangladesh
Authors: Mahumud Rashidul Alam , Gow Jeff , Sarker Abdur Razzaque , Sultana Marufa , Hossain Golam , Alam Khorshed
Published: March 2020

This study investigates the influence of household socioeconomic status and maternal risk factors and health-care service availability on changes in the under-five mortality rate (U5MR) in Bangladesh. Potential risk factors that influence U5MRs were investigated using multilevel logistic regression analysis and 29,697 data points from the Bangladesh Demographic and Health Surveys, 2004–2014. Maternal and child health parameters such as childhood morbidity, low vaccination coverage, poor utilization of perinatal care, and malnutrition were found to be more concentrated in poorer households. Pooled estimates indicated that the aggregate odds of U5MR risk declined by 18% to 2007 to 38% to 2014 compared to 2004. However, inadequate antenatal care, short birth interval, primiparity, illiteracy, delayed conception, and low socioeconomic status were significantly associated with a higher risk of under-five mortality. The magnitude of inequality using these measures were significantly associated with large variations in U5MR changes. Although a significant reduction in U5MR in Bangladesh was found in this study, substantial socioeconomic variations still persist. The analysis suggests that decreasing inequality in society is required for further reductions in child mortality. This will help to achieve a more equitable distribution of child and neonatal outcomes and assist the achievement of Sustainable Development Goals 3.2 by 2030.
Polyethylene Glycol–Based Nanocerium Improves Healing Responses in Excisional and Incisional Wound Models in Rats
Authors: Kardan Tara , Mohammadi Rahim , Taghavifar Saeed , Cheraghi Marzieh , Yahoo Ashkan , Mohammadnejad Kianoush
Published: March 2020

Applications of nanotechnology have gained progressive interest for regeneration of injured wound tissue. The aim of the present study was to evaluate effects of polyethylene glycol (PEG)-based nanocerium on excisional and incisional wound models in rats. For excisional wound healing model, 24 male white Wistar rats were randomized into 4 groups of 6 rats each: control group with creation of wounds and no treatment, PEG group with creation of wounds and dressing the wound with PEG, NanoCer group with application of 1 mL nanocerium on the wound, and PEG/NanoCer group with dressing the wound with PEG-based nanocerium. Wound size was measured on days 6, 9, 12, 15, 18, and 21 postsurgery. For incisional wound healing model, 24 healthy male Wistar rats were randomized into 4 groups of 6 rats each the same way in the excisional wound model. Reduction in wound area, hydroxyproline contents, and biomechanical parameters indicated that there was a significant difference ( P > .05) between PEG/NanoCer and other groups. Biomechanical testing was performed on day 9 postsurgery in the incisional model. Biochemical and quantitative histological studies demonstrated that there was a significant difference ( P > .05) between PEG/NanoCer and other groups. PEG/NanoCer offered potential advantages in wound healing acceleration and improvement through angiogenesis stimulation, fibroblast proliferation, and granulation tissue formation on early days of healing phases. Acceleration in wound repair was associated with earlier wound area reduction and enhanced tensile strength of damaged area by rearrangement of granulation tissue and collagen fibers. PEG-based nanocerium could have therapeutic benefits in wound healing.
The random forest algorithm for statistical learning
Authors: Schonlau Matthias , Zou Rosie Yuyan
Published: March 2020

Random forests (Breiman, 2001, Machine Learning 45: 5–32) is a statistical- or machine-learning algorithm for prediction. In this article, we introduce a corresponding new command, rforest. We overview the random forest algorithm and illustrate its use with two examples: The first example is a classification problem that predicts whether a credit card holder will default on his or her debt. The second example is a regression problem that predicts the logscaled number of shares of online news articles. We conclude with a discussion that summarizes key points demonstrated in the examples.
When to consult precision-recall curves
Authors: Cook Jonathan , Ramadas Vikram
Published: March 2020

Receiver operating characteristic (ROC) curves are commonly used to evaluate predictions of binary outcomes. When there is a small percentage of items of interest (as would be the case with fraud detection, for example), ROC curves can provide an inflated view of performance. This can cause challenges in determining which set of predictions is better. In this article, we discuss the conditions under which precision-recall curves may be preferable to ROC curves. As an illustrative example, we compare two commonly used fraud predictors (Beneish’s [1999, Financial Analysts Journal 55: 24–36] M score and Dechow et al.’s [2011, Contemporary Accounting Research 28: 17–82] F score) using both ROC and precision-recall curves. To aid the reader with using precision-recall curves, we also introduce the command prcurve to plot them.
Auditory Cortex Volume and Gamma Oscillation Abnormalities in Schizophrenia
Authors: Hirano Yoji , Oribe Naoya , Onitsuka Toshiaki , Kanba Shigenobu , Nestor Paul G. , Hosokawa Taiga , Levin Margaret , Shenton Martha E. , McCarley Robert W. , Spencer Kevin M
Published: March 2020

We investigated whether the gray matter volume of primary auditory cortex (Heschl’s gyrus [HG]) was associated with abnormal patterns of auditory γ activity in schizophrenia, namely impaired γ synchronization in the 40-Hz auditory steady-state response (ASSR) and increased spontaneous broadband γ power. (The γ data were previously reported in Hirano et al, JAMA Psychiatry, 2015;72:813-821). Participants were 24 healthy controls (HC) and 23 individuals with chronic schizophrenia (SZ). The ASSR was obtained from the electroencephalogram to click train stimulation at 20, 30, and 40 Hz rates. Dipole source localization of the ASSR was used to provide a spatial filter of auditory cortex activity, from which ASSR evoked power and phase locking factor (PLF), and induced γ power were computed. HG gray matter volume was derived from structural magnetic resonance imaging at 3 T with manually traced regions of interest. As expected, HG gray matter volume was reduced in SZ compared with HC. In SZ, left hemisphere ASSR PLF and induced γ power during the 40-Hz stimulation condition were positively and negatively correlated with left HG gray matter volume, respectively. These results provide evidence that cortical gray matter structure, possibly resulting from reduced synaptic connectivity at the microcircuit level, is related to impaired γ synchronization and increased spontaneous γ activity in schizophrenia.
Concomitant Anterior and Posterior Component Separations: Absolutely Contraindicated?
Authors: Daes Jorge , Winder Joshua S. , Pauli Eric M.
Published: March 2020

Many experts in abdominal wall reconstruction believe that the combination of simultaneous ipsilateral anterior component separation (ACS) and posterior component separation (PCS) is contraindicated. We performed ipsilateral endoscopic ACS and either endoscopic or open PCS-transversus abdominis release (TAR) in 5 fresh cadaver models. The full length of the semilunar line and the lateral abdominal wall remained well reinforced by 2 complete layers, comprising the internal oblique (IO) and TA muscles and their investing fasciae. Myofascial releases occurred 4 cm (median) apart. Additionally, we reviewed computed tomography images at 1 month and 1 year after PCS-TAR in 17 patients (30 PCS-TARs). Lateral displacement of the TA relative to the rectus abdominis (RA) was significant only at the superior mesenteric artery level, where it was <1 cm (median). Muscle mass changed minimally over time. Several studies showed that abdominal wall reconstruction after PCS-TAR results in compensatory muscular hypertrophy of the RA, external oblique (EO), and IO muscles and provides better quality of life and improved core physiology. These changes did not occur when the midline was not restored. Theoretically, endoscopic ACS-EO may be added to PCS-TAR to avoid partially bridged mesh repair in patients in whom complete midline restoration is impossible via PCS-TAR alone. Nevertheless, we advise most surgeons to perform a small-bridged repair instead of risking increased morbidity by attempting a highly complicated procedure.
Serum Proteins as New Biomarkers for Whole-Body Exposure to High- and Low-LET Ionizing Radiation
Authors: Wei Wenjun , Bai Hao , Feng Xiu , Hua Junrui , Long Kaiqin , He Jinpeng , Zhang Yanan , Ding Nan , Wang Jufang , Zhou Heng
Published: March 2020

Exposure to ionizing radiation is a major threat to human health and public security. Since the inherent limitations of current methods for indicating radiation exposure, new minimally invasive biomarkers that can be easily and quickly detected at an early stage are needed for optimal medical treatment. Serum proteins are attractive biomarkers and some radiosensitive proteins have been found, but the proteins in response to low-dose and high-linear energy transfer (LET) radiation have not been reported. In this study, mice were whole body exposed to a variety doses of carbon ions and X-rays. We performed Mouse Antibody Array to detect serum proteins expression profiles at 24 hours postirradiation. After conditional screening, insulin-like growth factor-1 (IGF-1), insulin-like growth factor binding protein-1 (IGFBP-1), and IGFBP-3 were further validated using enzyme-linked immunosorbent assay. After exposure to 0.05 to 1 Gy of carbon ions and 0.5 to 4 Gy of X-rays, only IGFBP-3 showed obvious increase with increased doses, both carbon ions and X-rays. Further, IGFBP-3 was detected for observation of its time-dependent changes. The results showed the expression difference of IGFBP-3 presented from 6 to 24 hours post-irradiation by carbon ions and X-rays. Moreover, the receiver–operating characteristic analysis showed that serum IGFBP-3 is efficient to triage exposed individuals with high sensitivity and specificity. These results suggest that serum IGFBP-3 is extremely sensitive to high- and low-LET ionizing radiation and is able to respond at an early stage, which could serve as a novel minimally invasive indicator for radiation exposure.
Application of artificial neural networks for quantitative damage detection in unidirectional composite structures based on Lamb waves
Authors: Qian Cheng , Ran Yunmeng , He Jingjing , Ren Yi , Sun Bo , Zhang Weifang , Wang Rongqiao
Published: March 2020

This article provides a quantitative nondestructive damage detection method through a Lamb wave technique assisted by an artificial neural network model for fiber-reinforced composite structures. For simulating damages with a variety of sizes, rectangular Teflon tapes with different lengths and widths are applied on a unidirectional carbon fiber–reinforced polymer composite plate. Two characteristic parameters, amplitude damage index and phase damage index, are defined to evaluate effects by the shape of the rectangular damage in the carbon fiber–reinforced polymer composite plate. The relationships between the amplitude damage index and phase damage index parameters and the damage sizes in the carbon fiber–reinforced polymer composite plate are quantitatively addressed using a three-layer artificial neural network model. It can be seen that a reasonable agreement is achieved between the pre-assigned damage lengths and widths and the corresponding predictions provided by the artificial neural network model. This shows the great potential of using the proposed artificial neural network model for quantitatively detecting the damage size in fiber-reinforced composite structures.
Improvements on the virtual obstacle method
Authors: Zheng Yuan , Shao Xueming , Chen Zheng , Zhang Jing
Published: March 2020

While the artificial potential field has been widely employed to design path planning algorithms, it is well-known that artificial potential field-based algorithms suffer a severe problem that a robot may sink into a local minimum point. To address such problems, a virtual obstacle method has been developed in the literature. However, a robot may be blocked by virtual obstacles generated during performing the virtual obstacle method if the environments are complex. In this article, an improved virtual obstacle method for local path planning is designed via proposing a new minimum criterion, a new switching condition, and a new exploration force. All the three new contributions allow to overcome the drawbacks of the artificial potential field-based algorithms and the virtual obstacle method. As a consequence, feasible collision-free paths can be found in complex environments, as illustrated by final numerical simulations.
Ethical considerations of Bedouin Arab school leaders: Negotiating Eurocentric and indigenous decision-making values
Authors: Eyal Ori , Da’as Rima’a , Berkovich Izhak
Published: March 2020

Ethical considerations have been examined in American and European school management research, but indigenous and comparative aspects have largely been understudied. To better understand the ethical decision-making of indigenous school leaders, the present research aims to examine the ethical considerations of one such minority group – Bedouin Arab educators in Israel – and to compare their ethical decision-making with that of their counterparts in Israel’s Jewish majority. The research utilized the pre-designed multiple Ethical Perspectives Instrument, which requires participants to resolve school dilemmas by choosing one of two given ethical perspectives taken from the following six: fairness, utilitarianism, care, critique, profession and community. Two exploratory studies were carried out: Study 1 examined the ethical judgments of Bedouin bachelor of education (BEd) students ( n = 28), and their perceptions of the ethical judgments of hypothesized Bedouin school leaders. Study 2 compared the ethical judgments of Bedouin ( n = 30) and Jewish ( n = 39) masters (MA) educational administration students. Bedouin undergraduates reported care and critique as their own dominant ethical preferences, but viewed utilitarian considerations as being dominant among hypothesized Bedouin school leaders. Among the graduate students, utilitarian considerations were more dominant among the Bedouin group than the Jewish group. The implications of the findings are discussed.
Assessment of the global warming potential associated with the construction process of healthcare centres
Authors: García-Sanz-Calcedo Justo , de Sousa Neves Nuno , Fernandes João Paulo Almeida
Published: March 2020

The carbon footprint reveals the emission profile of a healthcare building and, when quantified properly, is useful for the design of effective mitigation plans. This article aims to determine the global warming potential associated with the healthcare centre building process in Spain at a 100-year perspective. To this end, six healthcare centres built between 2007 and 2010 were analysed, and the emissions associated with the manufacturing, transport and placement of materials on site – including the final tests and commissioning of the building – were calculated. The results show that the average CO2 equivalent emission per m2 built is 1122.30 kg (standard deviation = 136.46), 1.24 kg (standard deviation = 0.19) per euro spent and 71.35 kg (standard deviation = 7.13) per hour spent on construction. Emissions per user, worker, electrical power and energy consumed were also classified. The material manufacturing and installation stages generate the most emissions, and healthcare centres larger than 2000 m2 appear to emit less CO2 equivalent per m2 when being built than smaller centres. The construction elements that caused most greenhouse gas emissions were also identified. These parameters allow extracting and designing proposals for improvements in environmental management.
A one-pot synthesis of benzimidazoles via aerobic oxidative condensation of benzyl alcohols with o-phenylenediamines catalyzed by [MIMPs]+Cl-/NaNO2/TEMPO
Authors: Geng Zhenzhen , Zhang Hong-yu , Yin Guohui , Zhang Yuecheng , Zhao Jiquan
Published: March 2020

The ionic liquid 1-methyl-3-(3-sulfopropyl)imidazolium chloride ([MIMPs]+Cl-) in combination with 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO) and sodium nitrite (NaNO2) as a catalytic system demonstrates high efficiency in the one-pot two-step aerobic oxidative condensation of benzyl alcohols with 1,2-phenylenediamines to give benzimidazoles. Various benzimidazoles are obtained in good to excellent yields by this strategy.
Brain Networks of Emotional Prosody Processing
Authors: Grandjean Didier
Published: March 2020

The processing of emotional nonlinguistic information in speech is defined as emotional prosody. This auditory nonlinguistic information is essential in the decoding of social interactions and in our capacity to adapt and react adequately by taking into account contextual information. An integrated model is proposed at the functional and brain levels, encompassing 5 main systems that involve cortical and subcortical neural networks relevant for the processing of emotional prosody in its major dimensions, including perception and sound organization; related action tendencies; and associated values that integrate complex social contexts and ambiguous situations.
Whose ‘Identity’? Multiculturalism vs. Integration in Europe
Authors: Virgili Tommaso
Published: March 2020

This article examines the question of migration from the perspective of long-term integration. In recent decades, the latter has often yielded to multicultural policies shaped on the recognition of groups and their alleged identities and demands. Through a case study of blasphemy against Islam, this article argues that multiculturalism has three main flaws: first, it shrinks the complexity of identities in order to assign individuals to pre-made boxes, thereby essentialising communities; second, it fosters social conflicts by opposing different groups and their supposed demands; and third, it creates a discriminatory system, contrary to the principles of equality and dignity. To avoid the ruination of the European dream of openness and diversity, it is necessary to return to an individualistic view of integration based on freedom, equality and universal citizenship.
Information and communication technology utilization effectiveness in distance education systems
Authors: Faisal Piliang , Kisman Zainul
Published: March 2020

Learning by using online application facilities through the Internet is a new service for all users. However, there are many problems and obstacles faced by users, both by students and by lecturers in utilizing online application services via the Internet. The development of a distance education service management software application model provides facilities for academics to facilitate interaction between students and lecturers with using online-based information technology communication services through the Internet. In addition, the management of distance education services is able to provide reports desired by students and lecturers using online-based information technology communication services through the Internet. This study used a descriptive–analytic method by presenting a summary of interviews and survey results in the form of a questionnaire to the faculty member. The method used is a qualitative method because it provides an explanation using analysis. This research uses Moodle application as a Distance Education System. The distance learning model used in the Trilogi University is considered sufficient, in terms of learning goals, learning materials, interactivity, and rules. The results also show that both lecturers and students argue that learning with a distance education system can simplify work, speed up work, accurate work, and be more efficient because it is interactive and user-friendly. This research can be applied to other school units or universities so that distance education services can help academics interact easily, quickly, and accurately. For its development, it can be applied using cellular-based applications.
Co-creation in new product development: Which drivers of consumer participation?
Authors: Mandolfo Marco , Chen Shan , Noci Giuliano
Published: March 2020

The present study investigates co-creation in new product development by providing a conceptual background in the psychological factors favoring consumer participation in company processes. The work explores the consumers’ profiles willing to participate in co-creation, through the identification of their personality traits, key motivations, and barriers. Two product typologies are investigated, namely high-tech and high-touch products through survey research on a sample of Italian consumers. Results from structural equation modeling show that consumers’ personality traits affect the perceived motivations and barriers to co-create, in turn shaping their willingness to co-create. Furthermore, consumer willingness to co-create varies depending on the product typology. Under a managerial viewpoint, the research study provides practitioners with keys to design targeted co-creation activities, fitting with the specific product typology and audience, and to devise the most suitable participation incentives to offer.
Anti-Inflammatory Activities of Kukoamine A From the Root Bark of Lycium chinense Miller
Authors: Wang Lin , Wang Peipei , Wang Dandan , Tao Mengqing , Xu Wenke , Olatunji Opeyemi Joshua
Published: March 2020

Kukoamine A (Kuk A) is a naturally occurring bioactive spermine alkaloid found in the root bark of Lycium chinense, and it exerts various therapeutic effects including antioxidant, neuroprotective, anti-inflammatory, and antidiabetic effects. This study evaluated the anti-inflammatory properties of Kuk A against lipopolysaccharide (LPS)-induced inflammation in RAW 264.7 macrophage cells and carrageenan-induced paw edema in rats. Pretreatment of cells with Kuk A significantly inhibited the production of reactive oxygen species, nitric oxide, prostaglandin E2, cyclooxygenase-2 activity, tumor necrosis factor-α, interleukin-1β (IL-1β), and IL-6 in LPS-treated cells. In addition, pretreatment of rats with Kuk A significantly decreased inflammatory response to carrageenan-induced paw edema by alleviating proinﬂammatory cytokines in the serum, malondialdehyde levels in the liver and increasing the activities of liver antioxidant enzymes (superoxide dismutase, catalase, and glutathione peroxidase) of carrageenan-treated rats. These results suggest the protective role of Kuk A in acute inflammatory reaction and could be useful in the treatment of inflammatory-related disorders.
A Synthetic Approach Toward a Brominated Oxocane Labdane Diterpenoid Isolated From Laurencia obtusa
Authors: Hagiwara Hisahiro , Fujiwara Shohei , Iibachi Chikako , Suzuki Toshio , Hoshi Takashi
Published: March 2020

The synthesis of a labdane oxocane epoxy-alcohol is described starting from the Wieland–Miescher ketone derivative via ring closing olefin metathesis of a diene derivative, targeting the total synthesis of a brominated oxocane labdane diterpenoid isolated from Laurencia obtusa.
Flower Infusions From Cornus mas and Cornus kousa Inhibit Aldose Reductase Enzyme, Without Any Effects on Lipotoxicity
Authors: Forman Vladimír , Šušaníková Ivana , Kukurová Ľubica , Švajdlenka Emil , Nagy Milan , Mučaji Pavel
Published: March 2020

Aldose reductase inhibitors are considered to be potential therapeutic agents for chronic diabetic complications. Diabetes mellitus can be accompanied by elevated blood levels of free fatty acids, which can cause lipotoxicity. Herbal extracts and their constituents are promising agents which have the potential for alleviating these complications. Our study was focused on the influence on these effects by flower infusions from Cornus mas L. and Cornus kousa F.Buerger ex Hance. Initially, phenolic compounds were quantified in the dried flowers. Next, we studied the ability of flower infusions from both plants to inhibit aldose reductase in vitro, the protective role in the cell model of lipotoxicity, and the cytotoxic action on fibroblast cell line NIH-3T3 by 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2 H-tetrazolium bromide assay. Both species are rich in phenolics; C. kousa flowers contain slightly higher amounts of phenolic acids (20.8%) and flavonoids (56.1%) than C. mas (20.2%) and (47.4%), respectively. Both extracts showed effective inhibition, expressed as half-maximal inhibitory concentration (IC50) (the concentration of inhibitor required to exhibit 50% inhibition of the enzyme reaction), of aldose reductase in non-toxic low concentrations (IC50 = 3.06 μg/mL for C. mas and IC50 = 2.49 μg/mL for C. kousa, respectively). In contrast, these concentrations of both extracts had almost no effects in the lipotoxicity cell model. To our knowledge, this study is the first report on C. mas and C. kousa flowers’ aldose reductase inhibitory activity and influence upon lipotoxicity.
The Role of Acetate in the Antagonization of Oxalate: A Potential Causative Molecule for Heart Disease and Cancer Death
Authors: An Shanshan , Li Xiaoxia , Tang Man , Xing Meng , Zhang Ying , Peng Jingli , Xu Li , Liu Qiuyun
Published: March 2020

Previous reports demonstrated the anticancer effects and the protective effects on cardiovascular diseases of vinegar products. The molecular mechanism underlying these phenomena is not well elucidated. It was proposed that carcinogenesis is triggered by the formation of local strong acids such as HCl. Cancer cells may overproduce weak or moderate organic acids such as oxalate to antagonize strong acids, and calcium oxalate may cause organ failure and death. This study aimed at elucidating the underlying mechanism on the antagonism of apoptosis by acetate on oxalate. Quantitation of cell apoptosis of HEK293T cells in the presence of sodium oxalate and compounds with similar structures to oxalate was conducted by using Annexin V-fluorescein isothiocyanate/propidium iodide staining via flow cytometry. The data indicate that acetate could attenuate the proapoptotic functions of oxalate. This study yields insight into the anticancer and antidisease functions of vinegar products and opens up a new path in the use of weak acetic acid in the prevention and treatment of cancer.
Genetic engineering and social justice: A reflection on Amartya Sen’s capability approach
Authors: Arambala Gerry F
Published: March 2020

Over the past decades, biomedical researchers have made great progress in finding the treatment for many diseases which have been considered in the past as incurable. The struggle for longevity and positive health has been addressed by medical science. People who can afford it are assured by the promise of genetic engineering. But while there has been considerable development in the treatment of diseases, the number of mortalities in poor countries remains high, especially in Sub-Saharan Africa and East Asia. Around 8 million people die each year worldwide due to poverty-related health issues. Despite the advancement in the treatment of diseases, poor people in most of the developing countries worldwide are dying each year. This article will argue that human poverty and the existence of infectious diseases are inseparable social phenomena that affect the fate of the poor in developing countries. Following Amartya Sen, this article will argue that access to advanced health care services should be affordable to all, and should form part of individual freedoms that the national policies of a country must secure.
Radon From the Ground into Our Schools: Parent and Guardian Awareness of Radon
Authors: Martin Kirsten , Ryan Rebecca , Delaney Thomas , Kaminsky David A. , Neary Scott J. , Witt Ethan E. , Lambert-Fliszar Florence , Remy Kyle , Sanford Shawn , Grenoble Kathryn , Carney Jan K.
Published: March 2020

Radon is the leading cause of lung cancer among non-smokers. Exposure in schools may be harmful to schoolchildren and staff. However, states differ considerably in their approaches to mandating radon testing and mitigaiton in schools. In this study, 126 survey responses were received and analyzed from parents of K-12 children in Vermont, USA. Qualitative data were obtained by interviewing two parents for their views and concerns about radon in schools. Our results showed that only 51% of parents believed that radon affects the lungs and only 39% identified it as a carcinogen. 91% believed their children’s schools should act to address elevated radon levels and 87% supported mandated mitigation. These data suggest that there is already overwhelming support for radon regulation in schools among parents of K-12 children. Parents with children in elementary school were significantly more likely to support radon testing, mitigation, and legislation than parents with older children. This suggests that these parents may be strong advocates to encourage legislative action. Parents with more knowledge about radon were significantly more likely to support radon testing in schools. Educating parents about exposure to radon at school and its association with lung cancer could strengthen existing community support for legislation mandating radon testing and mitigation.
Temporal Distance and Descriptive Norms on Environmental Behaviors: A Cross-Cultural Examination of Construal-Level Theory
Authors: Park Hee Sun , Ulusoy Ezgi , Choi Soe Yoon , Lee Hye Eun
Published: March 2020

Rapid urbanization has beset sustainable consumption. Although many countries are increasingly taking pro-environmental stances, most countries continue to have a low recycling rate and a high littering rate. This study examines the effect of temporal distance as a part of Construal-Level Theory and descriptive norms on pro- and contra-environmental behaviors (i.e., recycling and littering) cross-culturally. Participants were recruited from the United States and South Korea, and randomly assigned to one of five versions of the survey. Findings indicated stronger intention to recycle for the distant future (only 3-year) and no significant difference for littering. Americans showed higher likelihood to recycle than Koreans while Koreans showed higher likelihood to litter when temporal distance was disregarded. Situational descriptive norms showed significant differences cross-culturally, but the interaction of culture and time distance was not visible. Theoretical implications for Construal-Level Theory research and practical implications for environmental policymakers in encouraging pro-environmental behaviors are discussed.
Predicting Penetration of the Project Buffer Time of Critical Chain Project Management (CCPM) Using a Linear Programming Approach
Authors: Jagtap Milind
Published: March 2020

Managing the disruptions in projects is a challenging task for project managers. In this respect, critical chain project management (CCPM) has been considered as a promising methodology in expediting projects. However, the effectiveness of this methodology is often lost in search of optimal use of project buffers to hedge against delays occurring in the critical chain. The more critical chain activity gets delayed, the greater is the likelihood of penetration of project buffer time. The resource constraints of critical chains have been considered as a major determinant of project buffer penetration. Although a project buffer is provided to protect the critical chain, to keep the CCPM project schedule competitive, it is the priority of the project manager to minimize the blatant consumption of project buffer time by multiple critical chain activities. Historically, resource constraints within the critical chain have been associated with penetration of project buffer time.

The literature suggests that the productivity of resources deployed in the critical chain can predict the penetration of project buffer time. Based on the premise that delays are omnipresent and unavoidable but predictable, this research aims to consider the post-facto measures of delays instead of pre-facto measures. Pre-facto measures are resources productivity and resources availability while post-facto measures are the compensation paid by the client and the cost of liquidity damages incurred by the contractor. It is assumed that pre-facto measures are convertible into post-facto measures. A linear programming model is formulated and tested using the case of Botanical Garden Construction Project in Pune city. Sensitivity analysis revealed that the propensity of project buffer penetration on a critical chain varies with the compensation matrix. Varieties of scenario are developed and the optimal solution is validated with the case study.
Benefits Formulation in Construction Projects: An Exploratory Study through a Social Sustainability Perspective
Authors: Goel Ashish , Ganesh L.S. , Kaur Arshinder
Published: March 2020

Extant project management literature suggests that project benefits management (PBM) can facilitate social sustainability (SS) through benefits formulation for a wider set of project stakeholders. However, empirical evidence regarding the actual extent of SS considerations in benefits formulation is lacking, especially from large developing economies like India. To fill this gap, a SS-centric analysis of PBM plans of 80 construction projects has been conducted using content analysis to identify the benefits targeted at the internal and external stakeholders, viz., workers and project-affected community. The analysis reveals much higher occurrences of benefits for the affected community compared to those relating to the workers. The project proponents have highlighted the social relevance of projects mostly through ‘trickle down benefits’ – that may possibly accrue to the affected communities due to project investment – as compared to ‘co-created benefits’ – that empower the affected communities but require a deeper understanding of their needs and aspirations. ‘Local employment’ and ‘local business and economic growth’ are the most common benefits across projects. Three areas of improvement have been suggested in the benefits formulation process from a SS perspective – mandating worker-specific benefits, more focus on co-created benefits and specifying numeric measures of benefits along with timelines, to facilitate assessment of actual benefits realization during project implementation and operation phases. This study contributes to research literature on sustainable project management. Its findings offer useful implications for researchers, policymakers and project proponent organizations.
Stevens-Johnson Syndrome–Like Reaction After Exposure to Pembrolizumab and Recombinant Zoster Vaccine in a Patient With Metastatic Lung Cancer
Authors: Riano Ivy , Cristancho Cagney , Treadwell Thomas
Published: March 2020

Stevens-Johnson syndrome (SJS) is a life-threating mucocutaneous reaction predominantly induced by drugs. Targeted cancer therapies such as pembrolizumab, which has been approved for the treatment of metastatic malignancy, can cause severe skin toxicities, including SJS. They are rare and inconsistently reported. In this article, we report the case of a 80-year-old woman with metastatic non–small cell lung cancer who had a SJS-like eruption involving oral mucosa after 15 weeks of exposure of pembrolizumab (6 doses) and 7 days after 1 dose of recombinant zoster vaccine. SJS is a rare blistering disorder with high mortality rate and significant morbidity. Causes include drugs, herpes viruses, and immunization. The timing of the eruption soon after the receipt of recombinant zoster vaccine suggests a role of vaccination in our patient, yet patients receiving cancer immunotherapy may develop late-onset skin toxicity. Therefore, we recommend long-term monitoring for mucocutaneous reactions after initiation of pembrolizumab. Further research is needed to characterize the immunological pathogenesis and improve timely recognition and treatment strategies.
Transition from Pediatric to Adult HIV Care for Young Women Living with HIV
Authors: Kennedy Victoria Logan , Mellor Kaitlyn Luisa , Brophy Jason , Bitnun Ari , Alimenti Ariane , Kakkar Fatima , Logie Carmen Helen , Webster Kath , Proulx-Boucher Karène , Ding Erin , Jabbari Shahab , Kaida Angela , de Pokomandy Alexandra , Loutfy Mona ,   on behalf of the CHIWOS Research Team
Published: March 2020

Transitioning from pediatric to adult care is a complicated process for youth with chronic illnesses. This study elucidates the unique factors affecting transition preparedness and perception of adult HIV care among a cohort of young women with HIV. Between 2013 and 2015, 48 women with HIV, who had experience with pediatric HIV care, were enrolled in a large Canadian cohort study. Variables were self-reported during peer-administered surveys. Only 60% reported feeling prepared for transition. Having never had contact with child protection services ( P = .049), never been in foster care ( P = .011), never been in a group home ( P = .036), reporting a higher current CD4 count ( P = .033), and reporting a younger ideal age for transition ( P = .041) were associated with transition preparedness. Eighty-four percent reported equivalent or better HIV care following transition. Correlates of equivalent/better care following transition included lower personal income ( P = .023), higher CD4 count ( P = .021), care by an adult infectious diseases specialist ( P = .002), and transition preparedness ( P = .005). Our findings highlight the importance of adequate transition preparation and its effect on perception of care following transition.
Streamlining the KOOS Activities of Daily Living Subscale Using Machine Learning
Authors: Gupta Ashim , Potty Ajish S.R. , Ganta Deepak , Mistovich R. Justin , Penna Sreeram , Cady Craig , Potty Anish G.
Published: March 2020

Background:

Functional outcome scores provide valuable data, yet they can be burdensome to patients and require significant resources to administer. The Knee injury and Osteoarthritis Outcome Score (KOOS) is a knee-specific patient-reported outcome measure (PROM) and is validated for anterior cruciate ligament (ACL) reconstruction outcomes. The KOOS requires 42 questions in 5 subscales. We utilized a machine learning (ML) algorithm to determine whether the number of questions and the resultant burden to complete the survey can be lowered in a subset (activities of daily living; ADL) of KOOS, yet still provide identical data.

Hypothesis:

Fewer questions than the 17 currently provided are actually needed to predict KOOS ADL subscale scores with high accuracy.

Study Design:

Cohort study (diagnosis); Level of evidence, 2.

Methods:

Pre- and postoperative patient-reported KOOS ADL scores were obtained from the Surgical Outcome System (SOS) data registry for patients who had ACL reconstruction. Categorical Boosting (CatBoost) ML models were built to analyze each question and its value in predicting the patient’s actual functional outcome (ie, KOOS ADL score). A streamlined set of minimal essential questions were then identified.

Results:

The SOS registry contained 6185 patients who underwent ACL reconstruction. A total of 2525 patients between the age of 16 and 50 years had completed KOOS ADL scores presurgically and 3 months postoperatively. The data set consisted of 51.84% male patients and 48.16% female patients, with a mean age of 29 years. The CatBoost model predicted KOOS ADL scores with high accuracy when only 6 questions were asked ( R2 = 0.95), similar to when all 17 questions of the subscale were asked ( R2 = 0.99).

Conclusion:

ML algorithms successfully identified the essential questions in the KOOS ADL questionnaire. Only 35% (6/17) of KOOS ADL questions (descending stairs, ascending stairs, standing, walking on flat surface, putting on socks/stockings, and getting on/off toilet) are needed to predict KOOS ADL scores with high accuracy after ACL reconstruction. ML can be utilized successfully to streamline the burden of patient data collection. This, in turn, can potentially lead to improved patient reporting, increased compliance, and increased utilization of PROMs while still providing quality data.
A space structural mechanics model of silicene
Authors: Motamedi Mohsen
Published: March 2020

The two-dimensional nanostructures such as graphene, silicene, germanene, and stanene have attracted a lot of attention in recent years. Many studies have been done on graphene, but other two-dimensional structures have not yet been studied extensively. In this work, a molecular dynamics simulation of silicene was done and stress–strain curve of silicene was obtained. Then, the mechanical properties of silicene were investigated using the proposed structural molecular mechanics method. First, using the relations governing the force field and the Lifson–Wershel potential function and structural mechanics relations, the coefficients for the BEAM elements was determined, and a structural mechanics model for silicene was proposed. Then, a silicene sheet with 65 Å × 65 Å was modeled, and Young’s modulus of silicene was obtained. In addition, the natural frequencies and mode shapes of silicene were calculated using finite element method. The results are in good agreement with reports by other papers.
Relationship Between Demographic and Radiographic Characteristics and Second Ray Pathology in Hallux Valgus Patients
Authors: Cronin Samantha , Conti Matthew , Williams Nicholas , Ellis Scott J.
Published: March 2020

Background:

Hallux valgus can alter load bearing in the foot leading to abnormal forces on the second toe. The purpose of this study was to determine demographic and radiographic factors associated with second ray hammertoes in hallux valgus using 3-dimensional weightbearing CT scans.

Methods:

Seventy-one patients who underwent a modified Lapidus procedure for hallux valgus with preoperative weightbearing CT scans were separated into 2 groups: (1) hallux valgus only (47 feet) and (2) hallux valgus with second ray hammertoe (29 feet). Preoperative age, body mass index (BMI), sex, hallux valgus angle (HVA), intermetatarsal angle (IMA), absolute and effective metatarsal (MT) lengths, ratios between metatarsal lengths, Meary angle, metatarsus adductus angle (MAA), and pronation were measured. Mean values of continuous variables were compared and both simple and multivariable logistic regression models were used to evaluate associations between variables and hammertoe occurrence.

Results:

Patients in the hammertoe group were found to be significantly older and have higher BMIs, HVAs, effective second MT lengths, IMAs, and more apex plantar Meary angles (all P < .05). The multivariable analysis demonstrated that a higher IMA and a more apex plantar Meary angle were the only significant predictors of second ray hammertoe risk ( P = .03 and P = .01, respectively) once corrected for age and BMI.

Conclusion:

Significant associations were found between older age, higher BMI, and more severe deformity and the occurrence of hammertoe in hallux valgus patients. These results may help clinicians counsel hallux valgus patients about the risk of developing an advanced hammertoe deformity.

Level of Evidence:

Level III, retrospective comparative series
A human SIRPA knock-in xenograft mouse model to study human hematopoietic and cancer stem cells
Authors: Jinnouchi Fumiaki , Yamauchi Takuji , Yurino Ayano , Nunomura Takuya , Nakano Michitaka , Iwamoto Chika , Obara Teppei , Miyawaki Kohta , Kikushige Yoshikane , Kato Koji , Maeda Takahiro , Miyamoto Toshihiro , Baba Eishi , Akashi Koichi , Takenaka Katsuto
Published: March 2020

In human-to-mouse xenogeneic transplantation, polymorphisms of signal-regulatory protein α (SIRPA) that decide their binding affinity for human CD47 are critical for engraftment efficiency of human cells. In this study, we generated a new C57BL/6.Rag2nullIl2rgnull (BRG) mouse line with Sirpahuman/human (BRGShuman) mice, in which mouse Sirpa was replaced by human SIRPA encompassing all 8 exons. Macrophages from C57BL/6 mice harboring Sirpahuman/human had a significantly stronger affinity for human CD47 than those harboring SirpaNOD/NOD and did not show detectable phagocytosis against human hematopoietic stem cells. In turn, Sirpahuman/human macrophages had a moderate affinity for mouse CD47, and BRGShuman mice did not exhibit the blood cytopenia that was seen in Sirpa−/− mice. In human to mouse xenograft experiments, BRGShuman mice showed significantly greater engraftment and maintenance of human hematopoiesis with a high level of myeloid reconstitution, as well as improved reconstitution in peripheral tissues, compared with BRG mice harboring SirpaNOD/NOD (BRGSNOD). BRGShuman mice also showed significantly enhanced engraftment and growth of acute myeloid leukemia and subcutaneously transplanted human colon cancer cells compared with BRGSNOD mice. BRGShuman mice should be a useful basic line for establishing a more authentic xenotransplantation model to study normal and malignant human stem cells.
Prognostic and predictive impact of genetic markers in patients with CLL treated with obinutuzumab and venetoclax
Authors: Tausch Eugen , Schneider Christof , Robrecht Sandra , Zhang Can , Dolnik Anna , Bloehdorn Johannes , Bahlo Jasmin , Al-Sawaf Othman , Ritgen Matthias , Fink Anna-Maria , Eichhorst Barbara , Kreuzer Karl-Anton , Tandon Maneesh , Humphrey Kathryn , Jiang Yanwen , Schary William , Bullinger Lars , Mertens Daniel , Lurà Michele Porro , Kneba Michael , Döhner Hartmut , Fischer Kirsten , Hallek Michael , Stilgenbauer Stephan
Published: March 2020

Genetic parameters are established prognostic factors in chronic lymphocytic leukemia (CLL) treated with chemoimmunotherapy, but are less well studied with novel compounds. We assessed immunoglobulin heavy variable chain (IGHV) mutation status, common genomic aberrations, and gene mutations in 421 untreated patients within the CLL14 trial (NCT02242942), comparing obinutuzumab+chlorambucil (GClb) vs obinutuzumab+venetoclax (VenG). The incidences of genomic aberrations considering the hierarchical model were del(17p) 7%, del(11q) 18%, +12 18%, and del(13q) 35%, whereas IGHV was unmutated in 60% of patients. NOTCH1 mutations were most common (23%), followed by SF3B1 (16%), ATM (13%), and TP53 (10%). Although the overall response rate (ORR) for GClb was lower in patients with del(17p), del(11q), mutated TP53, ATM, and BIRC3, none of these parameters reduced complete remission (CR) rate and ORR with VenG. At a median follow-up of 28 months, del(17p) and mutated TP53 were the only abnormalities with an effect on progression-free survival (PFS) for both treatment groups: GClb (hazard ratio [HR], 4.6 [P < .01]; HR, 2.7 [P < .01], respectively) and VenG (HR, 4.4 [P < .01]; HR, 3.1 [P < .01], respectively). No other factors affected outcome with VenG, whereas for GClb del(11q), BIRC3, NOTCH1, and unmutated IGHV were associated with shorter PFS. Multivariable analysis identified del(17p), del(11q), unmutated IGHV, and mutated TP53, BIRC3, and SF3B1 as independent prognostic factors for PFS with GClb, whereas for VenG, only del(17p) was significant. VenG was superior to GClb across most genetic subgroups. Patients with adverse genetic markers had the strongest benefit from VenG, particularly subjects with unmutated IGHV, which was identified as a predictive factor in a multivariable treatment-interaction analysis.