bluuebunny/crossref_metadata_2025 huggingface dataset:
Proton Conduction Properties of Intrinsically Sulfonated Covalent Organic Framework Composites
Authors: Yang Jianjian , Kong Zhihui , Li Xinyu , Guo Qinglei , Wang Zhen , Kang Zixi , Wang Rongming , Sun Daofeng
Published: July 2023

The long–term stability of proton conductors is one of the most important factors in evaluating materials. Guest molecules can act as “bridges” for proton conduction channels and reside in the channels of covalent organic frameworks, but they are prone to leakage. Therefore, it is important to develop proton conductors with intrinsic proton conductivity. In this paper, we synthesized an intrinsically sulfonated covalent organic framework, TpPa–SO3H, which has a more stable proton conducting performance than that of TpPa@H2SO4 by loading guest molecules. Meanwhile, the proton conductivity of TpPa–SO3H was further improved by coating a superabsorbent polymer through an in situ reaction to obtain PANa@TpPa–SO3H (PANa: sodium polyacrylate). As a result, the modified composite exhibits an ultrahigh proton conductivity of 2.33 × 10−1 S cm−1 at 80 °C under 95% relative humidity (RH). The stability of PANa@TpPa–SO3H makes it an efficient proton transport platform with excellent proton conductivity and long–term durability.
Method for Decontamination of Toxic Aluminochrome Catalyst Sludge by Reduction of Hexavalent Chromium
Authors: Pyagay Igor , Zubkova Olga , Zubakina Margarita , Sizyakov Viktor
Published: July 2023

The article is devoted to the neutralization of the harmful effects of aluminochrome catalyst sludge. Catalyst sludge is a waste product from petrochemical production and poses a serious threat to the environment and humans because of the toxic hexavalent chromium it contains. The emissions of Russian petrochemical enterprises’ alumochrome sludge is 10,000–12,000 tons per year. In this paper, research related to the possibility of reducing the harmful effects of sludge by converting hexavalent chromium to a less dangerous trivalent state is presented. The reduction of hexavalent chromium was carried out with different reagents: Na2SO3, FeSO4, Na2S2O3, and Na2S2O5. Then, a comparative analysis was carried out, and sodium metabisulfite was chosen as the most preferred reagent. The peculiarity of the reducing method was carrying out the reaction in a neutral medium, pH = 7.0. The reduction was carried out in the temperature range of 60–85 °C and under standard conditions. The maximum recovery efficiency of chromium from the catalyst sludge (100%) was achieved at 85 °C and 10 min. This method did not involve the use of concentrated sulfuric acid, as in a number of common techniques, or additional reagents for the precipitation of chromium in the form of hydroxide.
Characteristics of Electrocardiogram Findings in Fulminant Myocarditis
Authors: Dai Mei-Yan , Yan Yong-Cui , Wang Lu-Yun , Zhao Chun-Xia , Wang Dao-Wen , Jiang Jian-Gang
Published: July 2023

Fulminant myocarditis (FM) is an acute and severe form of myocarditis with rapid progression and poor clinical outcomes in the absence of acute or chronic coronary artery disease. Electrocardiogram (ECG) abnormalities can provide preliminary clues for diagnosis; however, there is a lack of systemic descriptions on ECG changes in FM populations. Thus, a retrospective analysis of 150 consecutive FM patients and 300 healthy controls was performed to determine the characteristic ECG findings in FM. All patients included had markedly abnormal ECG findings. Specifically, 83 (55.33%) patients had significantly lower voltage with remarkably decreased QRS amplitudes in all leads compared with healthy controls (p < 0.01), and 77 (51.33%) patients had a variety of arrhythmias with lethality ventricular tachycardia/ventricular fibrillation in 21 (14.00%) patients and third-degree atrioventricular block in 21 (14.00%) patients, whereas sinus tachycardia was only found in 43 (28.67%) patients with the median heart rate (HR; 88.00 bpm, IQR: 76.00–113.50) higher than that of controls (73.00 bpm, IQR: 68.00–80.00) (p = 0.000). Conduction and repolarization abnormalities were common in patients. A longer QTc interval (452.00 ms, IQR: 419.00–489.50) and QRS duration (94.00 ms, IQR: 84.00–119.00) were observed in patients compared to controls (QTc interval = 399.00 ms, IQR: 386.00–414.00; QRS duration = 90.00 ms, IQR: 86.00–98.00) (p < 0.05). Additionally, HR > 86.50 bpm, QTc > 431.50 ms, and RV5 + SV1 < 1.715 mV can be used to predict FM. Thus, marked and severe ECG abnormalities provide preliminary clues for the diagnosis of FM.
Preventing and Managing Radial Artery Occlusion following Transradial Procedures: Strategies and Considerations
Authors: Tsigkas Grigorios , Papanikolaou Amalia , Apostolos Anastasios , Kramvis Angelos , Timpilis Filippos , Latta Anastasia , Papafaklis Michail I. , Aminian Adel , Davlouros Periklis
Published: July 2023

Τransradial artery access has recently gained widespread acceptance as the preferred approach for coronary angiography and interventions, due to its lower incidence of bleeding and vascular complications compared to transfemoral access. However, thrombotic occlusion of the radial artery has emerged as the most common complication of this method, impeding its use in future interventions, and in the creation of arteriovenous fistulae for hemodialysis patients, or as a graft for coronary artery bypasses grafting. In this comprehensive review, we delve into the anatomy of the radial artery, the pathophysiology and diagnosis of radial artery occlusion, the identification of potential risk factors and, finally, prevention and treatment strategies. We acknowledge that distal transradial access provides an effective alternative for coronary angiography and catheterizations, with a reduced incidence of radial artery occlusion.
A New Proximal Adjustable Sling ATOMS SSP® Implantation Technique with Focus on the Urethral Bulb: Lessons Learned from Revision Surgery
Authors: Queissert Fabian , Bruecher Benedict , Schrader Andres J.
Published: July 2023

Background: Adjustable sling ATOMS-SSP results in ventral compression of the urethra with favorable results in the treatment of men with mild to moderate stress incontinence. However, with transobturator tunneling and mesh fixation, the surgeon has a range of options, which leads to different results and sometimes unfavorable positioning of the silicone cushion. Using retrograde urethrography (RUG), we identified ATOMS patients with considerable misplacement. We then modified the implantation technique when we performed the revision, and now present here our first experiences with this new surgical technique. Methods: Patients after ATOMS-SSP implantation at our clinic were systematically subjected to a RUG if incontinence persisted after adjustments. In case of unfavorable positioning, a revision was performed with the aim of achieving an idealized urethroproximal position of the silicone pad. During follow-up, a repeat RUG was performed, and both subjective and objective outcome parameters were recorded. Results: Four men met the above criteria and underwent revision with reimplantation using our new technique. All patients postoperatively experienced significantly improved continence. RUGs demonstrated an ideal ATOMS position immediately below the proximal bulbar urethra. Conclusions: Our proximal implantation technique, presented here for the first time, allows optimal positioning of the ATOMS SSP, which is reflected in the objective parameters and RUG. Its use in primary implantation should also be considered and an expansion to the indication of severe stress incontinence seems possible, but this should only be done in studies.
Patient-Reported Outcome Measures following Coblation Nucleoplasty for Cervical Discogenic Dizziness
Authors: Li Yongchao , Wu Bing , Li Mao , Pang Xiaodong , Yang Liang , Dai Chen , Peng Baogan
Published: July 2023

Background: There is little research in the literature comparing the efficacy of coblation nucleoplasty with conservative treatment in the treatment of cervical discogenic dizziness and reporting the achieved rate of minimal clinically important differences (MCID) and patient acceptable symptom state (PASS) after surgery. This retrospective study aims to explore the patient-reported outcome measures (PROM) following coblation nucleoplasty for cervical discogenic dizziness and to compare the therapeutic effect of coblation nucleoplasty with prolonged conservative treatment. Methods: Sixty-one patients with cervical discogenic dizziness and a positive intradiscal diagnostic test eligible for single-level cervical coblation nucleoplasty were included in the study. Among these 61 patients, 40 patients underwent cervical coblation nucleoplasty, while the remaining 21 patients refused surgery and received continued conservative treatment. The primary PROMs were the intensity and frequency of dizziness and secondary PROMs were related to the neck disability index (NDI) and visual analog scale (VAS) for neck pain (VAS-neck) during a 12-month follow-up period. Moreover, the achieved rate of MCID and PASS in both groups was assessed 12 months after surgery. Results: Dizziness intensity, dizziness frequency, VAS-neck score, and NDI score were significantly improved from the baseline at all follow-up time points in both treatment groups, except for showing no significant improvement in dizziness frequency in the conservative treatment group at 6 and 12 months after surgery. However, at each follow-up time point, the above indexes were lower in the surgery group than in the conservative treatment group. In addition, the achieved rates for PASS and MCID in all indexes in the surgery group were significantly higher than those in the conservative treatment group at 12 months after surgery. Conclusions: Cervical coblation nucleoplasty significantly improved the intensity and frequency of dizziness, neck pain, and NDI in patients with cervical discogenic dizziness, and the results were superior to those from prolonged conservative treatment. Meanwhile, cervical coblation nucleoplasty is a good choice for patients with chronic neck pain and refractory cervical discogenic dizziness who have not demonstrated the indications for open surgery and have not responded well to conservative treatment.
Presence of Pleural Effusion in the Assessment of Remote Dielectric Sensing
Authors: Imamura Teruhiko , Izumida Toshihide , Yamamoto Riona , Nomoto Yu , Aakao Kousuke , Kinugawa Koichiro
Published: July 2023

Background: The remote dielectric sensing (ReDS) system is a recently introduced non-invasive technology used to easily estimate the degree of lung fluid volume without any expert techniques. In the previous literature, ReDS values had a moderate correlation with invasively measured pulmonary artery wedge pressure (PAWP), the gold standard for representing left heart preload. Considering the mechanism of ReDS technology, ReDS values may be inappropriately elevated in the presence of pleural effusion (PE), and the ability of the ReDS system to estimate PAWP may decrease in such a situation. Methods: In-hospital patients with cardiovascular diseases underwent computed tomography, and the presence of pleural effusion (PE) was evaluated. The measurement of ReDS values using the ReDS system and the measurement of PAWP using invasive right heart catheterization were also performed simultaneously. The impact of the presence of PE on the relationship between the ReDS values and PAWP was evaluated. Results: A total of 59 patients (79 years, 30 male) were included. The median ReDS value was 25% (IQR: 22%, 30%) and the median PAWP level was 13 (IQR: 10, 18) mmHg. Of these patients, 11 had PE. PAWP was not significantly different between the two groups, whereas the ReDS values in the PE group were significantly higher than in the no-PE group. The impact of the presence of PE on the ReDS values was significant, with a beta value of 6.61 (95% confidence interval: 4.80–8.42, p < 0.001) upon adjusting for the levels of PAWP. Conclusions: We should pay attention to interpreting ReDS values when assessing the degree of pulmonary congestion in patients with PE, because ReDS values may be inappropriately elevated in this cohort.
The Toll-like Receptor 7-Mediated Ro52 Antigen-Presenting Pathway in the Salivary Gland Epithelial Cells of Sjögren’s Syndrome
Authors: Nishihata Shin-Ya , Shimizu Toshimasa , Umeda Masataka , Furukawa Kaori , Ohyama Kaname , Kawakami Atsushi , Nakamura Hideki
Published: July 2023

Objective: To investigate whether stimulation with toll-like receptor (TLR) 7 leads to pathways that proceed to tripartite motif-containing protein 21 (TRIM21) or Ro52/SS-A antigen presentation through major histocompatibility complex (MHC) class I in salivary gland epithelial cells (SGECs) from Sjögren’s syndrome (SS) patients. Design and Methods: Cultured SGECs from SS patients were stimulated with TLR7 agonist, loxoribine, and interferon-β. Cell lysates immunoprecipitated by anti-MHC class I antibody were analyzed by Western blotting. The immunofluorescence of salivary gland tissue from SS and non-SS subjects and cultured TLR7-stimulated SGECs was examined. Results: Significantly increased MHC class I expression was observed in SS patients’ ducts versus non-SS ducts; no significant difference was detected for ubiquitin. Upregulated MHC class I in the cell membrane and cytoplasm and augmented Ro52 expression were observed in SGECs stimulated with TLR7. The formation of peptide-loading complex (PLC), including tapasin, calreticulin, transporter associated with antigen processing 1, and endoplasmic reticulum-resident protein 57 in labial salivary glands (LSGs) from SS patients, was dominantly observed and colocalized with MHC class I, which was confirmed in TLR7-stimulated SGEC samples. Conclusion: These findings suggest that the TLR7 stimulation of SS patients’ SGECs advances the process toward the antigen presentation of TRIM21/Ro52-SS-A via MHC class I.
Predicting Intraoperative Hypothermia Burden during Non-Cardiac Surgery: A Retrospective Study Comparing Regression to Six Machine Learning Algorithms
Authors: Dibiasi Christoph , Agibetov Asan , Kapral Lorenz , Zeiner Sebastian , Kimberger Oliver
Published: July 2023

Background: Inadvertent intraoperative hypothermia is a common complication that affects patient comfort and morbidity. As the development of hypothermia is a complex phenomenon, predicting it using machine learning (ML) algorithms may be superior to logistic regression. Methods: We performed a single-center retrospective study and assembled a feature set comprised of 71 variables. The primary outcome was hypothermia burden, defined as the area under the intraoperative temperature curve below 37 °C over time. We built seven prediction models (logistic regression, extreme gradient boosting (XGBoost), random forest (RF), multi-layer perceptron neural network (MLP), linear discriminant analysis (LDA), k-nearest neighbor (KNN), and Gaussian naïve Bayes (GNB)) to predict whether patients would not develop hypothermia or would develop mild, moderate, or severe hypothermia. For each model, we assessed discrimination (F1 score, area under the receiver operating curve, precision, recall) and calibration (calibration-in-the-large, calibration intercept, calibration slope). Results: We included data from 87,116 anesthesia cases. Predicting the hypothermia burden group using logistic regression yielded a weighted F1 score of 0.397. Ranked from highest to lowest weighted F1 score, the ML algorithms performed as follows: XGBoost (0.44), RF (0.418), LDA (0.406), LDA (0.4), KNN (0.362), and GNB (0.32). Conclusions: ML is suitable for predicting intraoperative hypothermia and could be applied in clinical practice.
Anatomical Single-Bundle Anterior Cruciate Ligament Reconstruction Using a Calcium Phosphate-Hybridized Tendon Graft with More than an Average of 5 Years of Follow-Up: A Follow-Up Study of a Randomized Controlled Trial
Authors: Mutsuzaki Hirotaka , Kinugasa Tomonori
Published: July 2023

Calcium phosphate (CaP)-hybridized tendon grafting using an alternate soaking process improves tendon-to-bone healing in anterior cruciate ligament (ACL) reconstructions. This study aimed to compare bone tunnel enlargement, knee osteoarthritis, and clinical results between CaP-hybridized tendon grafting and conventional grafting in anatomical single-bundle ACL reconstruction. This study was a follow-up of a randomized controlled trial. Between July 2011 and December 2015, 90 patients underwent unilateral anatomical single-bundle ACL reconstructions and were randomly assigned to the CaP-hybridized tendon grafting (CaP group, n = 45; age, 27.1 [14–54] years; sex, 21 males and 24 females) or conventional grafting (control group, n = 45; age, 22.9 [13–58] years; sex, 26 males and 19 females). The randomization was performed according to the days of the week when the patients first visited the outpatient. The CaP-hybridized tendon grafting was created intraoperatively. The tendon grafts were soaked in a calcium solution for 30 s. After that, the tendon grafts were soaked in a NaHPO4 solution for 30 s. This soaking cycle between the calcium solution and the NaHPO4 solution was repeated 10 times. The bone tunnel enlargement, osteoarthritis grade, clinical score, and sports level were evaluated in patients who could be followed up for >3 years (CaP group, n = 20, average follow-up period 6.0 [5.1–6.9] years; control group, n = 15, average follow-up period 5.6 [4.3–6.9] years). Clinical scores, sports levels, and osteoarthritis grades were analyzed using a generalized linear mixed model (GLMM) based on repeated measurement data from preoperative and final observations, with time, group, sex, age, and BMI as fixed effects and the effect of individual differences as variable effects. In addition, bone-tunnel enlargements were analyzed using generalized linear models (GLM) with group, sex, age, and BMI as the main effects. Compared with the control group, the CaP group exhibited significantly reduced bone-tunnel enlargement on the femoral side (anteroposterior diameter; CaP group, 7.9% [−1.1–16.8] vs. control group, 29.2% [17.9–40.5], p = 0.004, MCID 16.05, proximal-distal diameter; CaP group, 7.9% [−1.9–17.8] vs. control group, 22.8% [10.9–34.7], p = 0.062, MCID 15.00). The osteoarthritis grades progressed in both groups (p < 0.001). The clinical scores and sports levels were not significantly different between the groups. This study suggests that the calcium phosphate-hybridized tendon graft reduces femoral bone-tunnel enlargement after anatomical single-bundle anterior cruciate ligament reconstruction in an average >5-year follow-up period. A longer follow-up period is necessary to reveal the clinical effects of the calcium phosphate-hybridized tendon grafts in anterior cruciate ligament reconstruction.
State of the Art in Temporomandibular Joint Arthrocentesis—A Systematic Review
Authors: Siewert-Gutowska Marta , Pokrowiecki Rafał , Kamiński Artur , Zawadzki Paweł , Stopa Zygmunt
Published: July 2023

Temporomandibular joint disorders are a heterogenic group of clinical conditions, which impair physiological functioning of the masticatory system. Arthrocentesis of the temporomandibular joint has become a widely approved method for non-invasive treatment, bridging the gap between conservative and surgical approaches. Regardless of technique, treatment is based upon joint lavage and lysis of the inflammatory fibrous tissue adhesions, which, in turn, improves joint mobility and reduces pain and closed lock. Recently, approaches for intra-articular injections have been proposed as adjuvant or replacement therapy. The aim of this study was to assess the most efficient technique of arthrocentesis. A systematic search based on PRISMA guidelines, including a computer search with specific keywords, a reference list search and a manual search, was performed. Relevant articles were selected after three search rounds for final review. The studies pulled for the analysis presented information about the relevant predictors, including the technique of arthrocentesis (single- or two-needle method), fluid used for lavage (Ringer lactate or saline), volume of the fluid, application of the injectable, number of interventions, pain (VAS) and mouth opening scores (MMO) and follow-up. All cohorts showed improvement in mouth opening, but significant pain reduction was observed only in cohorts treated either by arthrocentesis alone or arthrocentesis followed by intra-articular injectables. Intra-articular injectables used alone failed to reduce pain post-operatively when compared to other cohorts. We concluded that both double-needle and single-puncture arthrocentesis techniques are equally efficient. Application of the adjuvant injectable did not improve the outcomes of arthrocentesis performed alone. The volume of the fluid used for joint lavage and its chemical composition were not significant in clinical outcomes. However, due to the lack of homogeneity in the study settings, a meta-analysis could not be applied and a systematic review was conducted. We still, however, state that there is a knowledge gap in the current literature regarding the use of injectables alone, as well as a longitudinal follow-up, which provides information about treatment efficiency. More high-quality and randomized controlled trials are required to shed light on this subject.
Dynamics of Bone Disease Biomarkers Dickkopf-1 and Sclerostin in Patients with Multiple Myeloma
Authors: Gerov Vladimir , Gerova Daniela , Micheva Ilina , Nikolova Miglena , Mihaylova Galya , Galunska Bistra
Published: July 2023

Dickkopf-1 (DKK-1) and sclerostin are essential Wnt/β-catenin pathway inhibitors, playing an important role in multiple myeloma bone disease (MBD). We aimed to examine the serum DKK-1 and sclerostin variations in newly diagnosed multiple myeloma (NDMM) patients at diagnosis and in the course of therapy, including autologous stem cell transplantation (ASCT). This study included 41 NDMM-patients and 33 controls. MBD was assessed by whole-body low-dose computed tomography. DKK-1 and sclerostin were assayed by commercial ELISA kits. At diagnosis, NDMM-patients revealed significantly higher DKK-1 and sclerostin values (p < 0.0001), showing dependence on disease stage (lowest in ISS-I and highest in ISS-III: p < 0.0012 and p < 0.025, respectively, for both proteins). Bone lesions revealed significant positive correlation with both DKK-1 (p < 0.05) and sclerostin (p < 0.0001). In the course of therapy, significant reduction, more prominent after ASCT, was observed for both parameters in each treatment point compared to the baseline (p < 0.0001). Markedly lower sclerostin (p < 0.01) and DKK-1 (p < 0.05) values were observed in patients with complete and very good partial response compared to those with partial response, stable, or progressive disease. Sclerostin and DKK-1 in NDMM patients reflect the MBD severity and the effect of therapy. Both proteins could represent a novel tool for better disease monitoring and effectiveness of therapy.
Diagnostic Applications of Intraoral Scanners: A Systematic Review
Authors: Angelone Francesca , Ponsiglione Alfonso Maria , Ricciardi Carlo , Cesarelli Giuseppe , Sansone Mario , Amato Francesco
Published: July 2023

In addition to their recognized value for obtaining 3D digital dental models, intraoral scanners (IOSs) have recently been proven to be promising tools for oral health diagnostics. In this work, the most recent literature on IOSs was reviewed with a focus on their applications as detection systems of oral cavity pathologies. Those applications of IOSs falling in the general area of detection systems for oral health diagnostics (e.g., caries, dental wear, periodontal diseases, oral cancer) were included, while excluding those works mainly focused on 3D dental model reconstruction for implantology, orthodontics, or prosthodontics. Three major scientific databases, namely Scopus, PubMed, and Web of Science, were searched and explored by three independent reviewers. The synthesis and analysis of the studies was carried out by considering the type and technical features of the IOS, the study objectives, and the specific diagnostic applications. From the synthesis of the twenty-five included studies, the main diagnostic fields where IOS technology applies were highlighted, ranging from the detection of tooth wear and caries to the diagnosis of plaques, periodontal defects, and other complications. This shows how additional diagnostic information can be obtained by combining the IOS technology with other radiographic techniques. Despite some promising results, the clinical evidence regarding the use of IOSs as oral health probes is still limited, and further efforts are needed to validate the diagnostic potential of IOSs over conventional tools.
The Effects of Nanoparticle Reinforcement on the Micromilling Process of A356/Al2O3 Nanocomposites
Authors: Sunar Talha , Parenti Paolo , Tunçay Tansel , Özyürek Dursun , Annoni Massimiliano
Published: July 2023

Improving scientific knowledge around the manufacturing of nanocomposites is key since their performance spreads across many applications, including those in meso/micro products. Powder metallurgy is a reliable process for producing these materials, but usually, machining postprocessing is required to achieve tight tolerances and quality requirements. When processing these materials, cutting force evolution determines the ability to control the microcutting operation toward the successful surface and part quality generation. This paper investigates cutting force and part quality generation during the micromilling of A356/Al2O3 aluminum nanocomposites produced via powder metallurgy. A set of micromilling experiments were carried out under various process parameters on nanocomposites with different nano-Al2O3 reinforcements (0–12.5 vol.%). The material’s ductility, internal porosity, and lack of interparticle bonding cause the cutting force generation to be irregular when nanoparticle reinforcements were absent or small. Reinforcement ratios higher than 2.5 vol.% strongly affect the cutting process by regularizing the milling force generation but lead to a proportionally increasing average force magnitudes. Hardening due to nano-reinforcement positively affects cutting mechanisms by reducing the plowing tendency of the cutting process, resulting in better surface quality. Therefore, a threshold on the nano-Al2O3 particles’ volumetric loadings enables an optimal design of these composite materials to support their micromachinability.
New Insights in Phenothiazinium-Mediated Photodynamic Inactivation of Candida Auris
Authors: Silva Abdênego R. , Cabral Fernanda V. , Silva Camila R. , Silva Daniela F. T. , Freitas Anderson Z. , Fontes Adriana , Ribeiro Martha S.
Published: July 2023

In recent years, Candida auris has emerged as a hazardous hospital-acquired pathogen. Its resistance to antifungal treatments makes it challenging, requiring new approaches to manage it effectively. Herein, we aimed to assess the impact of photodynamic inactivation mediated by methylene blue (MB-PDI) or 1,9-dimethyl MB (DMMB-PDI) combined with a red LED against C. auris. To evaluate the photoinactivation of yeasts, we quantified colony-forming units and monitored ROS production. To gain some insights into the differences between MB and DMMB, we assessed lipid peroxidation (LPO) and mitochondrial membrane potential (ΔΨm). After, we verified the effectiveness of DMMB against biofilms by measuring metabolic activity and biomass, and the structures were analyzed through scanning electron microscopy and optical coherence tomography. We also evaluated the cytotoxicity in mammalian cells. DMMB-PDI successfully eradicated C. auris yeasts at 3 μM regardless of the light dose. In contrast, MB (100 μM) killed cells only when exposed to the highest dose of light. DMMB-PDI promoted higher ROS, LPO and ΔΨm levels than those of MB. Furthermore, DMMB-PDI was able to inhibit biofilm formation and destroy mature biofilms, with no observed toxicity in fibroblasts. We conclude that DMMB-PDI holds great potential to combat the global threat posed by C. auris.
Stable Coronary Artery Disease: Who Finally Benefits from Coronary Revascularization in the Modern Era? The ISCHEMIA and Interim ISCHEMIA-EXTEND Analysis
Authors: Bershtein Leonid , Sumin Alexey , Zbyshevskaya Elizaveta , Gumerova Victoria , Tsurtsumia Darejan , Kochanov Igor , Andreeva Alina , Piltakian Vartan , Sayganov Sergey
Published: July 2023

Coronary revascularization is one of the most studied treatment modalities in cardiology; however, there is no consensus among experts about its indications in patients with stable coronary artery disease (SCAD). Contemporary data regarding the role of revascularization in SCAD are in clear conflict with the current European guidelines. This article discusses the main statements of the most significant American and European Guidelines on myocardial revascularization of the last decade and also analyzes the appropriateness of revascularization to improve the prognosis and symptoms in SCAD in the light of new research data, primarily the ISCHEMIA study (NCT01471522) and the ACC/AHA 2021 Revascularization Guidelines based on them. Data on the revascularization in SCAD obtained after the completion of ISCHEMIA (including the interim analysis of ISCHEMIA-EXTEND) and their potential significance are discussed. The results of ISCHEMIA sub-analyses in the most important “controversial” subgroups (3-vessel disease, proximal left anterior descending artery disease, strongly positive stress test, etc.) are reviewed, as are the results of the ISCHEMIA-CKD substudy in patients with severe chronic kidney disease (CKD).
Seed Treatment with Sodium Nitroprusside Ensures a Long-Term Physiological and Protective Effect on Wheat under Salinity
Authors: Maslennikova Dilara , Knyazeva Inna , Vershinina Oksana , Titenkov Andrey , Lastochkina Oksana
Published: July 2023

Although salinity inhibits plant growth, the use of a nitric oxide (NO) gasotransmitter can reduce its negative effects. In this study, the influence of 200 μM sodium nitroprusside (SNP) (donor of NO) on wheat plants (Triticum aestivum L., cv. Salavat Yulaev) in conditions of salinization (100 mM NaCl) was analyzed in pot experiments. Seed priming regulated the level of endogenous NO in normal and salinity conditions throughout the entire experiment (30 and 60 days). Salinity led to the strong accumulation of NO and H2O2, which is negative for plants, and significantly reduced leaf area and photosynthetic pigments (chlorophyll a and b and carotenoids). In addition, stress caused a drop in the content of reduced glutathione (GSH) and ascorbic acid (ASA), an accumulation of oxidized glutathione (GSSG), and significantly activated glutathione reductase (GR), ascorbate peroxidase (APX), and lipid peroxidation (LPO) in wheat leaves. SNP treatment significantly attenuated the negative effects of salinity on leaf area and photosynthetic pigments. An important indicator of reducing the damaging effect of salinity on treated plants is the stabilization of the content of GSH and ASA throughout the experiment (60 days). This condition has been associated with long-term modulation of GR and APX activity. Such an effect of 200 μM SNP may be related to its ability to reduce stress-induced accumulation of NO. Additional accumulation of proline also mitigated the negative effect of salinity on plants, and this also evidenced decreased LPO and H2O2 in them. For the first time, in natural growing conditions (small-scale field experiments), it was found that pre-sowing seed treatment with 200 μM SNP led to an improvement in the main yield indicators and an increase in the content of essential amino acids in wheat grains. Thus, SNP treatment can be used as an effective approach for prolonged protection of wheat plants under salinity and to improve grain yield and its quality.
Effect of Heat Treatment on the Microstructure and Mechanical Properties of 18Ni-300 Maraging Steel Produced by Additive–Subtractive Hybrid Manufacturing
Authors: Osman Mahmoud , Sarafan Sheida , Wanjara Priti , Bernier Fabrice , Atabay Sila Ece , Gholipour Javad , Molavi-Zarandi Marjan , Soost Josh , Brochu Mathieu
Published: July 2023

The present work investigates the effectiveness of two heat treatment cycles—solution treatment + aging (STA) and direct aging (DA)—on optimizing the microstructure and enhancing the mechanical properties of 18Ni-300 maraging steel (300 MS) produced by additive–subtractive hybrid manufacturing (ASHM). The STA treatment led to a fully martensitic microstructure with minor remnants of the cellular substructures associated with the solidification conditions in ASHM. DA resulted in some reverted austenite and partial dissolution of the cellular morphologies into shorter fragments. Despite the contrasting microstructures, the tensile strength and the macro- and micro-hardness were comparable between STA and DA conditions. By contrast, the potential for improving the ductility was higher with the DA heat treatment. This is attributed to the higher reverted austenite content in the samples treated by DA, i.e., up to a maximum of 13.4% compared to less than 3.0% in the STA samples. For the DA sample with the highest reverted austenite content of 13.4%, the highest local and global fracture strain values of 30.1 and 5.9 ± 0.6% were measured, while the respective values were 23.4 and 4.4 ± 0.1% for the corresponding STA sample. This work suggests that DA of 300 MS produced by ASHM is sufficient to achieve comparable hardness and tensile strength to STA, whilst maintaining reasonable ductility. Avoiding the solution treatment cycle, with its appreciably higher temperatures, could benefit the dimensional stability and surface quality that are important for ASHM of 300 MS parts.
Effect of Welding Defects on Fatigue Properties of SWA490BW Steel Cruciform Welded Joints
Authors: Xu Xingyuan , Xie Liyang , Zhou Song , An Jinlan , Huang Yanqing , Liu Youcheng , Jin Lei
Published: July 2023

Welding is prone to several defects. To test the fatigue properties of the welded defective joints of high-speed rail bogies, SMA490BW steel cruciform welded joints were employed with artificial defects treatment. Consequently, fatigue tests were conducted on the specimens. Fatigue fracture morphology was studied via scanning electron microscopy. The ABAQUS (version 2022) finite element software was used to calculate the stress distribution and concentration factor of cruciform welded joints with defects. The results show that the fatigue limits of 1 and 2.4 mm defect specimens were approximately 57.2 and 53.75 Mpa, respectively. Furthermore, the stress concentration factor of no, 1 mm, and 2.4 mm defects were 2.246, 4.441, and 6.684, respectively, indicating that the stress concentration factor of 1 and 2.4 mm defects increased by 98 and 198%, respectively, with respect to the no-defect case.
Processing of Niobium-Alloyed High-Carbon Tool Steel via Additive Manufacturing and Modern Powder Metallurgy
Authors: Borkovcová Klára , Novák Pavel , Merghem Nawel , Tsepeleva Alisa , Salvetr Pavel , Brázda Michal , Rajnovic Dragan
Published: July 2023

Niobium is recently considered one of the potential alloying elements for tool steels due to the formation of hard and stable carbides of MC type. Its use is limited by the fact that these carbides tend to coarsen during conventional melting metallurgy processing. This work explores the potential of additive manufacturing for processing Nb-alloyed tool steel with a high content of carbon. Directed energy deposition was used as the processing method. It was found that this method allowed us to obtain a microstructure very similar to that obtained after the use of consolidation via spark plasma sintering when subsequent heat treatment by soft annealing, austenitizing, oil quenching and triple tempering for secondary hardness was applied. Moreover, the soft annealing process could be skipped without affecting the structure and properties when machining would not be required. The hardness of the steel was even higher after additive manufacturing was used (approx. 800–830 HV 30) than after spark plasma sintering (approx. 720–750 HV 30). The wear resistance of the materials processed by both routes was almost comparable, reaching 5–7 × 10−6 mm3N−1m−1 depending on the heat treatment.
Effects of Different Pre-Heating Welding Methods on the Temperature Field, Residual Stress and Deformation of a Q345C Steel Butt-Welded Joint
Authors: Yuan Jie , Ji Hongchao , Zhong Yingzhuo , Cui Guofa , Xu Linglong , Wang Xiuli
Published: July 2023

Heavy plate welding has been widely used in the construction of large projects and structures, in which the residual stress and deformation caused by the welding process are the key problems to address to reduce the stability and safety of the whole structure. Strengthening before welding is an important method to reduce the temperature gradient, control the residual stress and reduce the deformation of welds. Based on the ABAQUS software, the thermal elastoplastic finite element method (FEM) was used to simulate the welding thermal cycle, residual stress and deformation of low-alloy, high-strength steel joints. Based on the finite element simulation, the influences of flame heating and ceramic heating on the temperature field, residual stress distribution and deformation of a Q345C steel butt-welded joint were studied. The results showed that the thermal cycle of the ceramic sheet before welding had little influence on the whole weldment, but had great influence on the residual stress of the weldment. The results show that the maximum temperature and residual stress of the welded parts are obviously weakened under the heating of ceramic pieces, and the residual stress of the selected feature points is reduced by 5.88%, and the maximum temperature of the thermal cycle curve is reduced by 22.67%. At the same time, it was concluded that the weld shapes of the two were basically the same, but the weld seams heated by ceramic pieces had a better weld quality and microstructures through comparing the macro- and micro-structures between the welded parts heated by ceramic pieces and the simulated weld. Heating before welding, therefore, is an effective method to obtain a high weld quality with less residual stress and deformation.
Evaluating the Efficiency of Magnetic Treatment for Feed Water in Reverse Osmosis Processes
Authors: Lei Qian , Elele Ezinwa , Shen Yueyang , Tang John , Guerra Katherine L. , Leitz Frank , Khusid Boris
Published: July 2023

The paper presents a new methodology for short-term (5–25 min) benchtop tests to evaluate the effectiveness of magnetic treatment of feed water for reducing mineral scaling on a reverse osmosis (RO) membrane. Scale deposition is measured at a controlled level of salt supersaturation in water flowing through an RO unit in once-through mode. A magnetic water conditioner is tested in a transient flow regime when variations of the permeate flux along the flow path are insignificant. Scale formation under these conditions is governed by salt crystallization on the membrane surface. The proposed method was implemented to investigate the influence of magnetic treatment on gypsum deposition on RO membranes in supersaturated aqueous CaSO4/NaCl solutions. The effects of magnetic water treatment on scale formation under our experimental conditions were found to be statistically insignificant with a confidence level of 95%. However, this outcome should not be considered to negate the potential efficiency of magnetic water treatment in specific applications. The proposed methodology of testing under a controlled level of salt supersaturation will also be useful for evaluating the efficiency of other water treatment technologies.
Silicas with Polyoxyethylene Branches for Modification of Membranes Based on Microporous Block Copolymers
Authors: Davletbaeva Ilsiya M. , Faizulina Zulfiya Z. , Li Ekaterina D. , Sazonov Oleg O. , Efimov Sergey V. , Klochkov Vladimir V. , Arkhipov Alexander V. , Davletbaev Ruslan S.
Published: July 2023

We have synthesized cubic and linear polysiloxanes containing polyoxyethylene branches (ASiP-Cu) using tetraethoxysilane, polyoxyethylene glycol, and copper chloride as precursors; the products are stable to self-condensation. The effect of copper chloride content on the chemical structure of ASiP-Cu has been established. A special study was aimed at defining the modifying effect of ASiP-Cu on the sorption characteristics of membranes based on microporous, optically transparent block copolymers (OBCs). These OBCs were produced using 2,4-toluene diisocyanate and block copolymers of ethylene and propylene oxides. The study demonstrated significantly increased sorption capacity of the modified polymers. On the basis of the modified microporous block copolymers and 1-(2-pyridylazo)-2-naphthol (PAN) analytical reagent, an analytical test system has been developed. Additionally, the modified OBCs have the benefit of high diffusion permeability for molecules of organic dyes and metal ions. It has been shown that the volume of voids and structural features of their internal cavities contribute to the complex formation reaction involving PAN and copper chloride.
Aerodynamics Optimization of Multi-Blade Centrifugal Fan Based on Extreme Learning Machine Surrogate Model and Particle Swarm Optimization Algorithm
Authors: Meng Fannian , Wang Liujie , Ming Wuyi , Zhang Hongxiang
Published: July 2023

The centrifugal fan is widely used in converting mechanical energy to aerodynamic energy. To improve the pressure of the multi-blade centrifugal fan used in an air purifier, an optimization process was proposed based on extreme learning machine (ELM) combined with particle swarm optimization (PSO). The blade definition position parameter and blade definition radian parameter were designed using the full-factor simulation experimental method. The steady numerical simulation of each experimental point was carried out using ANSYS CFX software. The total pressure of the multi-blade centrifugal fan was selected as the optimization response. The optimized ELM combined with the PSO algorithm considering the total pressure response value and the two multi-blade centrifugal fan parameters were built. The PSO algorithm was used to optimize the approximation blade profile to obtain the optimum parameters of the multi-blade centrifugal fan. The total pressure was improved from 140.6 Pa to 151 Pa through simulation experiment design and improved surrogate optimization. The method used in the article is meant for improving multi-blade centrifugal total pressure. The coupling optimization of impellers, volutes, and air intakes should be comprehensively considered to further improve the performance of centrifugal fans.
Study of Microstructure and Mechanical Properties of Electrodeposited Cu on Silicon Heterojunction Solar Cells
Authors: Shan Jeff , Shan Chung-Hsuan , Huang Craig , Wu Yu-Ping , Lia Yuan-Kai , Chen Wen-Jauh
Published: July 2023

This study investigated the use of a pure copper seed layer to improve the adhesion strength and reduce the residual stress of electroplated copper films for heterojunction technology in crystalline solar cells. The experiment involved depositing a copper seed layer and an indium tin oxide (ITO) layer on textured silicon using sputtering. This resulted in the formation of a Cu(s)/ITO/Si structure. Following this step, a 10 µm thick copper layer was electroplated onto the Cu(s)/ITO/Si structure. Various characterization techniques were employed to evaluate the electroplated copper films’ microstructures, residual stress, and adhesion strength. The microstructures of the films were examined using a scanning transmission electron microscope (STEM), revealing a twin structure with a grain size of approximately 1 µm. The residual stresses of the as-deposited and annealed samples were measured using an X-ray diffractometer (XRD), yielding values of 76.4 MPa and 49.1 MPa, respectively. The as-deposited sample exhibited higher tension compared to the annealed sample. To assess the adhesion strength of the electroplated copper films, peel-off tests were conducted at a 90° angle with a constant speed of 30 mm/min. The peel force, measured in units of N/mm, was similar for both the as-deposited and annealed samples. Specifically, the peel force for electroplating copper on the copper seed layer on the ITO was determined to be 2.6 N/mm for the maximum value and 2.25 N/mm for the average value. This study demonstrated that using a pure copper seed layer during electroplating can improve adhesion strength and reduce residual stress in copper films for heterojunction technology in crystalline solar cells. These findings contribute to the development of more reliable and efficient solar-cell-manufacturing processes.
A Novel Density of States (DOS) for Disordered Organic Semiconductors
Authors: Qin Dong , Chen Jiezhi , Lu Nianduan
Published: July 2023

In this work, we proposed a novel theory of DOS for disordered organic semiconductors based on the frontier orbital theory and probability statistics. The proposed DOS has been verified by comparing with other DOS alternatives and experimental data, and the mobility calculated by the proposed DOS is closer to experimental data than traditional DOS. Moreover, we also provide a detailed method to choose the DOS parameter for better use of the proposed DOS. This paper also contains a prediction for the DOS parameters, and it has been verified by the experimental data. More importantly, the physical meaning of the proposed DOS parameter has been explained by equilibrium energy theory and transport energy theory to make this proposed model more rational. Compared with the improved DOS based on Gaussian and exponential DOS, this work is a new attempt to combine probabilistic theory with physical theory related to DOS in disordered organic semiconductors, showing great significance for the further investigation of the properties of DOS.
Improved Stable Read Range of the RFID Tag Using Slot Apertures and Capacitive Gaps for Outdoor Localization Applications
Authors: Jouali Redouane , Ouahmane Hassan , Khan Jalal , Liaqat Maryam , Bhaij Azize , Ahmad Sarosh , Haddad Abderrahim , Aoutoul Mohssin
Published: July 2023

This paper proposes a small-size UHF RFID tag antenna, which was designed to function in the frequency interval of 860–960 MHz, with a large-read range of up to 17 m. In this work, the effects of capacitive slots and gaps on the impedance matching between conventional industrial chips and a designed RFID antenna was investigated. Simulated and measured results provided a clear indication that these two techniques can efficiently improve the return loss parameter and the antenna impedance matching behavior at the UHF band. Three-dimensional electromagnetic (EM) simulations results further proved that a better impedance matching between an industrial chip and a proposed RFID antenna occurs at 870 MHz, where the estimated input antenna impedance was about Za = 16 + j184 (Ω), and the calculated read range reached a value of up to 17 m with a measured return loss value of –14 dB. The proposed RFID antenna can almost maintain the same read range value over a 180 degree angle variations on the horizontal plane owing to its omnidirectional radiation pattern. The fabrication and test stages of the antenna prototype were scheduled to validate the simulated characteristics. Experimental results confirmed the performances of our proposed RFID tag antenna and proved its potential ability for localization applications. EM simulations have been performed using the well-known commercial EM software simulator CST MWS.