bluuebunny/crossref_metadata_2025 huggingface dataset:
Electroacupuncture of Weizhong (BL-40) Acupoint Inspires Muscular Satellite Cell Regeneration and Promotes Muscle Repair Capacity after Back Muscle Injury in Sprague-Dawley Rat Model
Authors: Huo Bi-Xiu , Wang Zhi-Ling , Jiao Ying-Qian , Wang Xiao-Yi , Lang Yan-Li , Mi Yong-Jun , Li Zhi-Xin , Ma Zhi-Zhong
Published: August 2022

Background. Back muscle injury is the most common illness involved in aged people. Muscular satellite cells, playing a key role in the muscle repairing process, are gradually losing their regenerative ability with aging, which attenuates the injured muscle repairing process. Electroacupuncture at Weizhong acupoint has been widely used in the treatment of young and aged patients with back muscle damage. Its efficacy has been proven by a randomized double-blind placebo clinical trial. However, the rehabilitation mechanisms are largely unknown. This study will explore the possible mechanisms associated with electroacupuncture at the Weizhong acupoint (BL 40) promoting muscle repairing ability. Method. A total of 58 male and female Sprague-Dawley rats were divided into a younger group (4-month-old) and an aged group (16-month-old), younger and aged rats were further divided as a sham, injured, injured rats treated with electroacupuncture at Weizhong point or treated with Non-Weizhong point groups. The back muscle injury model was produced in rats as a previously described method with modification. Furthermore, Weizhong acupoints underwent electroacupuncture treatment with 15 V magnitude, 2 Hz/10 Hz frequency density, 1.0 mA current intensity, and 10 min each day for 10 consecutive days using HANS’s electroacupuncture apparatus. After the last treatment, the paravertebral muscles and serum of all animals were undergone histological, immunohistochemistry, and flow cytometry analysis. Serum levels of Creatine Kinase (CK) and proinflammatory cytokine, interleukin 6 (IL-6), were measured separately by using ELISA kit. Results. Electroacupuncture of Weizhong (BL 40) acupoints significantly attenuated back muscle damage in both young and aged rats, increasing PAX7 (a marker of muscle satellite cells) and MYOD (major marker of myoblasts) cells, simultaneously, reducing serum proinflammatory cytokines, IL-6, and downregulation of p38 MAPK signaling in aged muscular satellite cells. Conclusion. Our studies suggest that electroacupuncture of Weizhong (BL 40) acupoints can restore aged back muscular satellite cells and their regeneration capacity. These suggested electroacupuncture may be a potential means of promoting rehabilitation for muscular injury in aged patients.
Green Approaches, Potentials, and Applications of Zinc Oxide Nanoparticles in Surface Coatings and Films
Authors: Rohani Rosiah , Dzulkharnien Nur Syafiqah Farhanah , Harun Nurul Hidayah , Ilias Iqma Asyila
Published: August 2022

Interest in the use of zinc oxide nanoparticles (ZnO NPs) in surface coatings and films has increased as its incorporation can significantly improve the mechanical and antimicrobial properties of coatings and film solutions. In an effort to produce green or eco‐friendly products, the potential use of ZnO NPs biosynthesized from natural resources to replace conventional petroleum‐derived polymers has been investigated. This review provides an insight into the growing trend of incorporating ZnO NPs into synthetic or semi‐synthetic or bio‐based polymeric materials via different synthesis methods as well as its characteristics and potential applications in surface coatings and films. The antimicrobial potential of ZnO NPs to inhibit the growth of various types of microorganisms as well as its use in surface coatings or films to impart antimicrobial activities that prevent the spread of microorganisms, especially the COVID‐19 virus, was also discussed.
Effect and Mechanism of Flavored Tongxie Yaofang Decoction for Diarrheal Irritable Bowel Syndrome under Intestinal Microecology
Authors: He Shunyong , Lin Qiong , Huang Jianfeng , Zheng Lin , Lai Jinmei , Chen Chaoyuan
Published: August 2022

This research was to analyze the effect of flavored Tongxie Yaofang on diarrheal irritable bowel syndrome (IBS) by the situation of intestinal microecology. The treatment mechanism was analyzed, so as to provide a more effective treatment method for patients clinically. 60 IBS patients were selected as the research objects and were divided according to the different treatment methods. For the control group (n = 20 cases), oral pinaverium bromide tablets were given. For the treatment group (n = 40 cases), the flavored Tongxie Yaofang decoction was given in addition to conventional treatment. The curative effects on the two groups of patients were evaluated in combination with the changes in intestinal microecology. With the syndrome score, the total effective rate of the treatment group (92.5%) was obviously superior to the control group (80%) (

P
<
0.05

). The clinical symptoms such as abdominal pain, abdominal distension, and diarrhea in the treatment group were significantly relieved after treatment in contrast to the control group (

P
<
0.05

). Intestinal Bifidobacterium, Escherichia coli, and Bifidobacterium/Escherichia coli (B/E) ratio were all greatly higher than those in the control group (

P
<
0.05

). In summary, flavored Tongxie Yaofang had a good effect in improving the symptoms of patients with diarrheal IBS and improved the microflora of Bifidobacterium and Escherichia coli in the intestinal tract of patients.
Multidisciplinary Case Management in Mesiodens Impacted Cases with Calcifying Odontogenic Cyst
Authors: Saskianti Tania , Tedjosaongko Udijanto , Pramudita Regina Ayu , Naomi Nita , Restu Alit Rahma
Published: August 2022

Calcifying odontogenic cyst (COC) is a cyst originating from odontogenic epithelium and has a characteristic ghost cell appearance. Clinically, COC is characterized by asymptomatic swelling, leading to lingual expansion, tooth migration, apical resorption, and perforation of cortical bone. COC is most often asymptomatic and is often only discovered during a routine radiological examination. This case report describes the clinical interventions to manage a patient with mesiodens impacted with COC. The procedure is aimed at evaluating the multidisciplinary management of COC at Universitas Airlangga Hospital, Surabaya. Multidisciplinary care has an important role in treating COC cases comprehensively.
Evaluating the Change Characteristics of the Microstructure of the Modified Plant Asphalt Using Soft Computing to Improve the Road Performance for Green Environment
Authors: Ji Weishuai , He Dongpo , Wu Di
Published: August 2022

Due to the diversity of plant asphalt sources and refining processes, the composition and properties of the various plant asphalts are also different. The plant asphalts are used to preserve the green environment. The natural material is eco-friendly; hence, the usage of plant asphalts is getting promoted these days. There are some problems in the road performance of some source plant asphalt, so the change characteristics of the microstructure of the modified plant asphalt are analyzed in this paper. Firstly, the raw materials are prepared, then the experimental plan is made, and finally the microstructure change characteristics of asphalt at different dosages of 0%, 0.25%, 0.5%, 0.75%, and 1% are studied using the soft computing techniques. It is found that with the increase of the content of polyphosphate, the structure of modified asphalt has changed. The most obvious change is that the volume of asphaltenes becomes smaller, the number of asphaltenes increases, the area of asphalt micelle becomes smaller, and the area of dispersion medium becomes larger. The experimental study is performed to guide the right material for road construction which is eco-friendly for maintaining the green environment.
Evaluation of Talent Training Model Taking into Account the Knowledge Recognition Algorithm of Multiple Constraint Models
Authors: Jing Yangjun
Published: August 2022

In the current talent model analysis, the phenomenon occurs such as serious errors, low efficiency, and poor accuracy. Based on this, a talent training model evaluation method is proposed based on multi-constraint model knowledge recognition algorithm. The knowledge recognition algorithm of the multiple constraint model is used to establish a talent training mode evaluation based on the knowledge recognition algorithm of the multiple constraint model, and the mode weight value is used to adjust the connection weights of the knowledge recognition algorithm of the multiple constraint model. The proposed knowledge recognition algorithm of the multiple constraint model is used to analyze the data index weights of the medical professional talent model in detail, to establish the appraisal model of the talent training. The model can effectively complete the evaluation and analysis of the comprehensive ability of medical professional talents. When using the classifier for training, 76% of the data feature dimensions can be selected for dimension reduction, so as to improve the imbalance problem under the training sample. The characteristics of the various constraint models designed in this paper can be tested by using the classifier. Finally, the experimental analysis results show that the application of the knowledge recognition algorithm of the multiple constraint model to the training mode of medical professionals can significantly enhance the accuracy of evaluation. It has certain reference significance in personnel training.
Efficacy Evaluation of Neoadjuvant Chemotherapy in Breast Cancer by MRI
Authors: Liu Yongguang , Wu Mingxiang , Tan Wenyong , Gong Jingshan , Ma Jie
Published: August 2022

Breast cancer is a highly harmful malignancy, which often causes great distress to patients and seriously affects their physical and mental health. Breast cancer causes patients to experience decreased appetite, decreased eating, and indigestion, which in turn leads to malnutrition, body wasting, resistance, immune compromise, progressive anemia, cachexia, and, as a result, severe secondary infections. To investigate the efficacy evaluation of neoadjuvant chemotherapy in breast cancer by MRI, forty‐eight subjects treated at the hospital from June 2014 to August 2019 were recruited. After the neoadjuvant chemotherapy, the patients were divided into two groups based on the results of histopathological examination, namely, the ineffective group (n = 14) and the effective group (n = 34). Changes in MRI indicators were compared between the two groups before and after the neoadjuvant chemotherapy. The maximum diameter of lesions decreased significantly after the neoadjuvant chemotherapy than before. The apparent diffusion coefficient (ADC) increased considerably, and the time‐intensity curve (TIC) showed a transition from type III to type II/I and from type II to type I. MRI can indicate the maximum diameter of the breast cancer lesion, ADC, and TIC type. Therefore, it can be used to evaluate the efficacy of neoadjuvant chemotherapy for breast cancer and be widely applied in clinical practice.
Evaluation of Black-Start Schemes Based on the Evaluation Indicator System
Authors: Xiang Zhongming , Lu Mengke , Ling Chengxiang , Li Tianyu , Wu Ye , Tong Cunzhi , Ma Xiang , Zhang Xiaocong , Zhang Chen
Published: August 2022

The black-start scheme is of great significance for the rapid recovery of the power system after a blackout. Most of the existing black-start scheme evaluations are studied from the perspective of improving the weight of evaluation indicators and evaluation methods, ignoring differences in the importance of evaluation indicators at different stages of recovery. Therefore, this study proposes a black-start scheme evaluation model based on the evaluation indicator system. First, starting from the elements of the black-start scheme, 14 evaluation indicators for the black-start scheme are proposed, concerning the characteristics of the grid nodes and the different stages of system recovery. Based on the analytic hierarchy process, the evaluation indicators are linked to the evaluation criteria of the system recovery stage to construct an evaluation indicator system for the black-start scheme. Second, the weight of the evaluation indicator is calculated by combining the analytic hierarchy process and the entropy weight method to obtain the result of the subjective and objective combination. Third, this study proposes an evaluation method integrating prospect theory and the multicriteria compromise solution ranking method, by combining the psychological perceived value of decision-makers with the characteristics of black-start schemes, to evaluate and rank black-start schemes. Finally, the rationality and accuracy of the evaluation model proposed in this study are verified by an example of the black-start scheme of Gansu power grid, which could provide a new idea for decision-makers to choose an appropriate black-start scheme.
Problems and Countermeasures of China’s International Trade in Agricultural Products under the Belt and Road Strategy Based on Big Data Analysis Technology in the Internet of Things Era
Authors: Ge Zhenlin
Published: August 2022

In order to study the analysis of China’s trade development under big data technology, through the analysis of the import and export of trade, the expansion of international trade exports of agricultural products, the adjustment of agricultural structure, the enrichment of import and export markets, the security of agricultural products, and other issues through the Internet of things technology and traditional technology, as well as the comparison of the overall effect, comprehensive performance, and coupling data, it can be seen that the agricultural trade under Internet of things technology is more convenient and faster. The application of network technology makes things better connected with people, changes the previous way of life, speeds up the development process of international trade, and realizes the real intelligent era.
Pavement Performance Evaluation of Asphalt Expressway Based on Machine Learning Support Vector Machine
Authors: Sun Qiao , Wang Guan , Sui Yanpeng , Zakaria Ideris
Published: August 2022

Pavement quality evaluation is important for pavement maintenance and is the basis for maintenance and investment decisions. With the use of asphalt pavements on highways, road maintenance problems are becoming increasingly serious. This paper introduces the prediction and evaluation of asphalt pavement and analyzes the quality evaluation methods of asphalt pavement in terms of damage degree, pavement smoothness, pavement gauge, and pavement strength. Based on this, a pavement quality evaluation based on machine learning, SVM, and other techniques is established, and a comprehensive evaluation model based on SVM, a set of asphalt pavement performance teaching materials, and a training label determination method are proposed to highlight the importance of highway asphalt pavement quality prediction and evaluation and provide reference for China’s highway construction.
Dexpramipexole Attenuates White Matter Injury to Facilitate Locomotion and Motor Coordination Recovery via Reducing Ferroptosis after Intracerebral Hemorrhage
Authors: Wang Bo , Zhang Xuyang , Zhong Jun , Wang Shi , Zhang Chao , Li Mingxi , Hu Quan , Wang Shuhong , Chen Lin , Chen Weixiang , Ge Hongfei , Feng Hua
Published: August 2022

Deciphering the factors causing damage to white matter fiber bundles and exploring new strategies to alleviate white matter injury (WMI) is a promising treatment to improve neurological impairments after intracerebral hemorrhage (ICH). Ferroptosis usually occurs at perihematomal region and contributes to neuronal death due to reactive oxygen species (ROS) production. Dexpramipexole (DPX) easily crosses the blood brain barrier (BBB) and exerts antioxidative properties by reducing ROS production, while the role of DPX in ferroptosis after ICH remains elusive. Here, our results indicated that ferroptosis played a significant role in WMI resulting from iron and ROS accumulation around hematoma. Further evidence demonstrated that the administration of DPX decreased iron and ROS deposition to inhibit ferroptosis at perihematomal site. With the inhibition of ferroptosis, WMI was alleviated at perihematomal site, thereafter promoting locomotion and motor coordination recovery in mice after ICH. Subsequently, the results showcased that the expression of glutathione peroxidase 4 (GPX4) and ferroptosis suppressing protein 1 (FSP1) was upregulated with the administration of DPX. Collectively, the present study uncovers the underlying mechanism and elucidates the therapeutic effect of DPX on ICH, and even in other central nervous system (CNS) diseases with the presence of ferroptosis.
Ethnogynaecological Knowledge of Traditional Medicinal Plants Used by the Indigenous Communities of North Waziristan, Pakistan
Authors: Rehman Sabith , Iqbal Zafar , Qureshi Rahmatullah , Ur Rahman Inayat , Khan Muazzam Ali , Elshaer Mohamed M. A. , Al Farraj Dunia A. , Elshikh Mohamed S. , Younas Muhammad , Sakhi Shazia , Nawaz Ghazala , Ali Niaz , Rahim Fazal , Ali Hamid , Khan Imran , Rahman Siddiq Ur , Abu Bakr Elsaid Noha M.
Published: August 2022

Background. Since the beginning of civilization, medicinal plants have been used in human healthcare systems. Studies have been conducted worldwide to evaluate their efficacy, and some of the results have triggered the development of plant-based medications. Rural women in Pakistan frequently experience gynaecological disorders due to malnutrition and heavy physical work during pregnancy. Due to the low economic status, the remoteness of the area, and the lack of modern health services, herbal therapy for gynaecological disorders is common among the indigenous tribes of the study area. Methods. Field surveys were carried out from April 2018 to October 2020 to collect data regarding medicinal plants used for different gynaecological disorders. A semistructured questionnaire was used to collect ethnogynaecological data. Results. In total, 67 medicinal plant species belonging to 38 families are being used to treat 26 different gynaecological problems. The herbaceous growth form and the Lamiaceae family were recorded with the maximum number of plant species (42 species and 7 species, respectively). Leaves are the most highly utilized plant part, with 16 species. In the case preparation method, decoction was the dominant method (25 species, 36.76%). The informants reported the maximum number of species for the treatment of irregular menstrual flow as 11 species (15.28%). The highest relative frequency of citation (RFC) value was obtained for Acacia modesta (0.37), and the use value (UV) for Tecomella undulata (0.85). The highest informants’ consensus factor (ICF) value (1.0) was obtained for emmenagogue and tonic each after delivery. The highest consensus index (CI%) value was calculated for Acacia modesta (36.92%). The Lamiaceae had the highest family importance value (FIV) (98.46%). Conclusion. This is the first ever quantitative study focusing mainly on ethnogynaecological study conducted in the tribal areas of North Waziristan which highlights the importance of traditional herbal remedies for their basic medical requirements. The results of this study would serve as a baseline for advanced phytochemical and pharmacological screening, as well as conservationists for further studies.
New Technological Measures of Sustainable Buildings in Triple Bottom-Line Analysis
Authors: Ding Yi
Published: August 2022

At present, China is in a period of rapid urbanization, and the concept of green structure is getting more and more attention. Green structures can solve asset utilization and ecological problems brought about by rapid urbanization. Therefore, green structure has become the only way for the development of China’s construction industry. This paper aims to study the feasibility analysis of new green building technology measures. The related concepts of green building, the analytic hierarchy process, and the meaning of life cycle cost are proposed. The main assessment bottom lines include engineering, environmental, social, and economic bottom lines. From the application examples of green building technology in the starting area of Guangzhou International Financial City, it can be seen that, based on the green building technology proposed in this paper, it is necessary to sort out specific technologies and practices suitable for the actual application of the project in a specific project. Then, the applicability and incremental cost of each technology can be analyzed, and finally, a green building technology system suitable for specific project applications is formed. The experimental results show that compared with residential buildings, the increase of public buildings is 338 million yuan, and the increase of nonassigned parts is about 9.84 million yuan.
Coupled Attention Framework of Convolutional Neural Network Based on Computer Intelligence
Authors: Yang Huoxiang , Liang Yongsheng , Liu Wei , Meng Fanyang , Li Chao
Published: August 2022

Using an attention mechanism based on the convolutional neural networks (CNNs) improves the performance of computer vision tasks by enhancing the representation of the features. The existing attention methods enhance the expression of the features by modeling the internal information of the features. However, due to the limited information flow of the previous features, these methods are difficult to calibrate features more completely. In this paper, we propose a Coupled Attention Framework (CAF) that is a simple attention framework for improving the performance of the existing attention methods. In the CAF, a coupling branch is added to an existing attention method to generate the input attention maps and enhance the input features of the convolution. The input attention is then spread to the output features through coupling between the input attention maps and convolution, the output features. The final result is the experimental results on various visual tasks. The results show that applying CAF to most of the existing attention methods can improve the performance with fewer parameters.
Apigenin Induced Apoptosis by Downregulating Sulfiredoxin Expression in Cutaneous Squamous Cell Carcinoma
Authors: Wang Wenhua , Liu Xin , Zhang Zhibao , Yin Mingzhu , Chen Xiang , Zhao Shuang , Wu Lisha
Published: August 2022

Cutaneous squamous cell carcinoma (cSCC) is the second carcinoma in nonmelanoma skin cancer (NMSC). Sulfiredoxin (Srx) is an antioxidant protein with a role in maintaining redox homeostasis. And Srx has an oncogenic role in skin tumorigenesis. In the current study, we found that apigenin, as a natural flavonoid, downregulated the expression of Srx protein in cSCC cell lines. Apigenin also inhibited the ability of cell proliferation and migration and induced apoptosis in cSCC cell lines. Our results also showed that apigenin induced apoptosis via the activation of the mitogen-activated protein kinase (MAPK) signaling pathway, as well as downregulated Srx expression in cSCC cell lines. Importantly, the effect of downregulation Srx by apigenin has been rescued with the inhibitor of the MAPK signaling pathway intervention. And induced apoptosis by apigenin was partially attenuated by the addition of MAPK inhibitor, Binimetinib. Our research revealed that apigenin induced apoptosis by downregulation of Srx expression through regulating the MAPK signaling pathway in cSCC cells, thus providing evidence of its applicability as a potentially effective therapeutic agent for cSCC treatment.
Efficacy of Traditional Chinese Medicine Combined with Chemotherapy in the Treatment of Gastric Cancer: A Meta-analysis
Authors: Zhang Wenxin , Zhao Yijuan , Liu Hongbo , Jing Chunying
Published: August 2022

Objective. Meta-analysis was conducted to explore the effects of CM combined with chemotherapy on the effective rate and survival rate of gastric cancer patients. Methods. Literature retrieval was performed in PubMed, MEDLINE, Embase, CENTRAL, and CNKI databases. The subject of the literature was to compare the efficacy of CM combined with chemotherapy and chemotherapy alone in patients with gastric cancer. According to the Cochrane manual, the risk of bias was assessed for inclusion in randomized controlled trials. The chi-square test was used for the heterogeneity test. Subgroup analysis and sensitivity analysis were used to explore the causes of heterogeneity. Funnel chart and Egger’s test were used to assess publication bias. Results. This study included 761 patients with gastric cancer from 10 literatures. The effective rate of chemotherapy in the CM combined group was higher than that in the chemotherapy alone group (odds ratio

OR

=
1.96

, 95% confidence interval (CI) (1.39, 2.78),

Z
=
3.81

,

P
=
0.0001

), and there was no heterogeneity among studies (

ch

i

2

=
5.68

,

P
=
0.68

,

I

2

=
0

%). There was no significant publication bias among all studies (

P
>
0.05

). The one-year survival rate in the CM combined group was higher than that in the chemotherapy alone group (

OR
=
3.25

, 95% CI (1.90, 5.54),

Z
=
4.32

,

P
<
0.0001

). There was no heterogeneity among studies (

ch

i

2

=
1.04

,

P
=
0.79

,

I

2

=
0

%) and no significant publication bias among studies (

P
>
0.05

). The 3-year survival rate of gastric cancer patients in the traditional Chinese medicine combination group was higher than that in the chemotherapy alone group (

OR
=
1.71

, 95% CI (1.06, 2.78),

Z
=
2.18

,

P
=
0.03

). There was no heterogeneity among studies (

ch

i

2

=
2.18

,

P
=
0.54

,

I

2

=
0

%), and there was no significant publication bias (

P
>
0.05

). The incidence of nausea and vomiting after chemotherapy in gastric cancer patients in the Chinese medicine combination group was lower than that in the chemotherapy alone group (

OR
=
0.47

, 95% CI (0.34, 0.64),

Z
=
4.80

,

P
<
0.00001

). There was no heterogeneity among studies (

ch

i

2

=
8.57

,

P
=
0.48

,

I

2

=
0

%), and there was no significant publication bias (

P
>
0.05

). Conclusion. CM combined with chemotherapy can improve the effective rate and survival rate of gastric cancer and reduce the incidence of nausea and vomiting after chemotherapy. We recommend a large sample size, multicenter combined randomized controlled trial for validation.
Efficacy and Safety of Moxibustion for Menopausal Obesity: A Multicentre, Randomized, Controlled Trial Protocol
Authors: Yu Benlu , Huang Wei , Zhang Yingrong , Wang Jiajie , Xia Chen , Zhang YanJi , Xia Hongjie , Hu Yaxin , Rao Yingyue , Zhou Zhongyu
Published: August 2022

Background. In the past, moxibustion has been widely used to treat endocrine system disorders, but evidence of its effectiveness is scarce at this point. The aim of this multicenter, randomized, controlled trial is to evaluate the efficacy and safety of treating menopausal obesity with moxibustion. Methods/Design. There are six centers taking part in this randomized, controlled, parallel trial. A total of 216 patients with menopausal obesity will be randomly divided into two equal groups: the “moxibustion for harmonization of Yin and Yang” group and the gentle moxibustion group. A 12-week study period with moxibustion will be preceded by a 1-week baseline, followed by a 12-week follow-up. We will conduct an interim analysis to determine whether or not the treatment is efficacious and safe after 216 participants have completed a 12-week treatment period. Evaluations will be conducted at weeks 0, 4, 8, 12, 18, and 24. The main outcome is waist circumference (WC), and the rate of WC reduction will be compared to the baseline. An intention-to-treat analysis will be performed with a two-sided

P

value of <0.05 considered significant. Participants who withdraw from the trial will be analyzed according to the intention-to-treat formula (ITT). Discussion. These results will be used to support selecting the right moxibustion prescription and guiding the improvement of clinical efficacy. This trial will provide convincing evidence of moxibustion’s effectiveness and safety in the treatment of obesity by “moxibustion for harmonization of Yin and Yang,” which will be conducive to the promotion and clinical application of the theory of “moxibustion for harmonization of Yin and Yang.” Trial Registration. This trial is registered with Clinical Trials.gov: NCT04943705 (registered on June 27, 2021).
Utilization of Rural Resource Assets: Time‐Space Estimate on the Total Factor Productivity
Authors: Wang Lan , Li Cong
Published: August 2022

The utilization efficiency of China’s rural collective resource assets has always been at a low level, and excessive energy consumption and input have become the main limiting factor, which seriously affects the overall improvement of agricultural modernization and rural people’s livelihood. In this paper, time measure and space measurement are adopted alternatively, and spatiotemporal vertical‐horizontal progressive deduction is built with the improved model, so as to set up a perfect spatiotemporal dynamic effect evaluation system: First of all, improve the U‐HDM‐GML index model, study on the improvement strategy for input redundancy and unexpected output redundancy in the utilization efficiency of rural collective resources assets in various provinces of China, as well as the equilibrium rupture relation between the two from the perspective of global space and time, and at the same time of fulfilment of time measurement and estimation, provide support for better expressing the spatial effect in terms of improving approach and strategy; secondly, measure the improvement strategy of the total factor productivity of research samples with the spatial expletory ESDA test method, and it is also applicable to global spatial effect evaluation system; finally, apply FE‐SDM to further analyze the difference of spatial effect of total factor productivity in rural resource asset utilization. Through analysis of the significant difference characteristics of the research samples with different geographical and spatial characteristics, the strategy deficiency in terms of difference discrimination is made up. Conclusions. This paper carries out the time and spatial effect measurement of total factor productivity for the performance of pilot strategies in various provinces of China in the last ten years and puts forward a more beneficial improved strategy and mechanism, preferentially selected according to the direction indicated by good research indicators, gets the redevelopment strategy for improving the utilization efficiency of areas at a low level of resources utilization currently, and indicates the direction for tapping the full potential of existing rural resources according to the practical conditions at local places, in the hope of establishing the trans‐provincial cooperation supply and demand system based on the new rural collective economic organizations (cooperatives) after the reform experimentation and optimizing the spatial spillovers of rural resources assets, so as to make a breakthrough in the barrier due to growth of technical efficiency.
FDA Approval Summary: Pembrolizumab for Neoadjuvant and Adjuvant Treatment of Patients with High-Risk Early-Stage Triple-Negative Breast Cancer
Authors: Shah Mirat , Osgood Christy L. , Amatya Anup K. , Fiero Mallorie H. , Pierce William F. , Nair Abhilasha , Herz Jonathan , Robertson Kim J. , Mixter Bronwyn D. , Tang Shenghui , Pazdur Richard , Beaver Julia A. , Amiri-Kordestani Laleh
Published: August 2022

On July 26, 2021, the FDA granted approval to pembrolizumab in combination with chemotherapy for neoadjuvant treatment and then continued as a single agent for adjuvant treatment following surgery for patients with high-risk, early-stage triple-negative breast cancer. Approval was based on results from KEYNOTE-522, an ongoing randomized (2:1) trial evaluating pembrolizumab or placebo in combination with chemotherapy for neoadjuvant treatment and then as a single agent for adjuvant treatment. The co-primary endpoints were pathological complete response (pCR) rate and event-free survival (EFS). The trial demonstrated an improvement in pCR and EFS in the pembrolizumab arm compared with the control arm. The number of patients who experienced an EFS event was 123 (16%) and 93 (24%), respectively [HR: 0.63, 95% confidence interval (CI), 0.48–0.82, P = 0.00031]. Patients on the pembrolizumab arm experienced EFS benefit regardless of tumor PD-L1 status. The absolute pCR rate improvement with the addition of pembrolizumab was 7.5% (95% CI, 1.6–13.4). Among patients receiving pembrolizumab, 44% experienced an immune-related adverse reaction. This article summarizes FDA's review of pembrolizumab and the data supporting the favorable benefit–risk assessment.
A Druggable UHRF1/DNMT1/GLI Complex Regulates Sonic Hedgehog–Dependent Tumor Growth
Authors: Yang Fan , Rodriguez-Blanco Jezabel , Long Jun , Swiderska-Syn Marzena , Wynn Daniel T. , Li Bin , Shen Chen , Nayak Anmada , Ban Yuguang , Sun Xiaodian , Suter Robert K. , McCrea Heather J. , Capobianco Anthony J. , Ayad Nagi G. , Robbins David J.
Published: August 2022

Dysregulation of Sonic hedgehog (SHH) signaling drives the growth of distinct cancer subtypes, including medulloblastoma (MB). Such cancers have been treated in the clinic with a number of clinically relevant SHH inhibitors, the majority of which target the upstream SHH regulator, Smoothened (SMO). Despite considerable efficacy, many of these patients develop resistance to these drugs, primarily due to mutations in SMO. Therefore, it is essential to identify druggable, signaling components downstream of SMO to target in SMO inhibitor resistant cancers. We utilized an integrated functional genomics approach to identify epigenetic regulators of SHH signaling and identified a novel complex of Ubiquitin-like with PHD and RING finger domains 1 (UHRF1), DNA methyltransferase 1 (DNMT1), and GLI proteins. We show that this complex is distinct from previously described UHRF1/DNMT1 complexes, suggesting that it works in concert to regulate GLI activity in SHH driven tumors. Importantly, we show that UHRF1/DNMT1/GLI complex stability is targeted by a repurposed FDA-approved therapy, with a subsequent reduction in the growth of SHH-dependent MB ex vivo and in vivo.

Implications:

This work describes a novel, druggable UHRF1/DNMT1/GLI complex that regulates SHH-dependent tumor growth, and highlights an FDA-approved drug capable of disrupting this complex to attenuate tumor growth.
Bronquiolitis eosinofílica con ETosis por eosinófilos en tapones mucosos tratada con éxito con benralizumab
Authors: Sasaki Hisashi , Miyata Jun , Irie Akiko , Kuwata Ayako , Kouzaki Yuji , Ueki Shigeharu , Kawana Akihiko
Published: August 2022

La bronquiolitis eosinofílica es un trastorno alérgico poco frecuente causado por inflamación eosinofílica en los bronquiolos pulmonares. Se requiere una estrategia de tratamiento eficaz en los casos resistentes a los esteroides. Sin embargo, su fisiopatología sigue sin estar clara debido al escaso número de casos. Presentamos aquí el caso de un hombre de 31 años que experimentó bronquiolitis eosinofílica con ETosis por eosinófilos (EETosis) en los tapones de moco. El paciente fue diagnosticado con asma. Los síntomas respiratorios empeoraron con eosinofilia cuando recibió el tratamiento estándar para el asma, que incluía corticosteroides inhalados, agonistas β2 de acción prolongada, antagonistas muscarínicos de acción prolongada y antagonistas de los receptores de leucotrienos. La tomografía computarizada torácica reveló engrosamiento de la pared bronquial y nódulos centrilobulares en los lóbulos inferiores de ambos pulmones. La broncoscopía mostró obstrucción del bronquio subsegmentario con tapones de moco. El análisis histológico demostró la presencia de abundantes eosinófilos en los tapones mucosos. También se observaron eosinófilos citolíticos junto con formaciones de cristales de Charcot-Leyden y la deposición de proteína básica mayor, lo que indicó la aparición de EETosis. La introducción de benralizumab, un anticuerpo contra el receptor α de la interleucina 5, controló con éxito el estado del paciente y redujo la cantidad de corticosteroides sistémicos administrados. Nuestros resultados confirman que este anticuerpo disminuye notablemente el número de eosinófilos en las vías respiratorias de pacientes con asma grave. Así pues, el benralizumab podría ser un agente terapéutico óptimo para el tratamiento de las enfermedades pulmonares eosinofílicas formadoras de tapones de moco o de EETosis, incluida la bronquiolitis eosinofílica.
Pulmonale Rundherde: Ermutigende Daten zur Kombination von radiärer Ultraschallsonde und 1,7-mm-Kryosonde
Authors: Hagmeyer Lars
Published: August 2022

Background: Cryobiopsy is an established technique that yields larger and higher-quality samples than does a forceps biopsy. However, it remains underutilised in the diagnosis of peripheral pulmonary lesions (PPLs), mainly because of difficulties in handling conventional cryoprobes. A recently introduced single-use cryoprobe with a smaller diameter and more flexibility than conventional ones may improve its diagnostic ability for PPLs. We conducted this prospective study to evaluate the feasibility of transbronchial cryobiopsy in the diagnoses of PPLs, using a new 1.7-mm cryoprobe. Methods: The study included patients with PPLs less than 30 mm in diameter scheduled to undergo bronchoscopy. All the procedures were performed using a combination of virtual bronchoscopic navigation, radial endobronchial ultrasound (R-EBUS) and X-ray fluoroscopy, and all the samples were collected using the cryoprobe alone. Thereafter, we assessed the diagnostic outcomes and safety profiles. Results: A total of 50 patients were enrolled and underwent cryobiopsy. The median lesion size was 20.8 mm (range, 8.2–29.6 mm), and the negative bronchus sign was seen in 34% of lesions. The diagnostic yield was 94% (95% confidence interval, 83.5–98.8%). A positive bronchus sign had a significantly higher diagnostic yield than did a negative bronchus sign (100% vs. 82.4%; P = 0.035). The yield was achieved regardless of other variables, including lesion size, location, and R-EBUS findings. The major complications were mild and moderate bleeding in 28% and 62% of patients, respectively. Pneumothorax was identified in one patient. Conclusion: Transbronchial cryobiopsy using the new 1.7-mm cryoprobe is a feasible procedure that has the potential to increase the diagnostic accuracy for PPLs. Trial registration Japan Registry of Clinical Trials, jRCT1032200065. Registered July 8 2020, https://jrct.niph.go.jp/en-latest-detail/jRCT1032200065
A Novel Combination of Keratinocyte and Autologous Microskin Grafting to Repair Full-Thickness Skin Loss
Authors: Yin Kai , Li Dawei , Shen Chuanan , Shang Yuru , Li Longzhu , Zhao Dongxu , Cheng Wenfeng
Published: August 2022

Introduction: The high mortality of patients with extensive deep burns is mainly attributed to the extensive burn wound and the scarce autologous skin left for wound repair. The purpose of this study was to explore how to effectively use the limited remaining autologous skin to repair the extensive deep wound. Methods: Human keratinocytes harvested from the foreskin were cultured and transfected with epidermal growth factors (EGFs) by an adenovirus vector (Ad-EGF). The expression and the biological activity of EGF in both the normal human keratinocytes and the EGF gene-modified human keratinocytes were quantified by ELISA assay and CCK-8 assay, respectively. The differentiated phenotype of epidermal cells was detected by immunofluorescence staining via CK10, CK14, and CK19 expressions. Rats were subjected to a full-thickness skin loss (3.3 cm × 3.0 cm) on the dorsum, which was repaired with the EGF gene-modified human keratinocyte suspension and autologous microskin and covered with the allogeneic skin. The wound healing was quantified, and the expression of EGF mRNA was measured by RT-PCR. Results: The EGF gene-modified human keratinocytes highly expressed EGF. CK10, CK14, and CK19 as keratinocyte differentiation markers were increased in the EGF gene-modified human keratinocytes. Wound healing was accelerated remarkably by the combination of autologous microskin grafting and EGF gene-modified human keratinocytes in vivo, and a very high EGF mRNA expression was observed in EGF gene-modified human keratinocytes groups on days 7 and 14 compared with other groups. Discussion/Conclusion: The EGF gene-modified human keratinocyte suspension may serve as promising seed cells which can effectively secrete EGF to accelerate wound repair in combination with autologous microskin grafting and reduce the autologous skin requirement for wound repair.
The Construction of Executive Function in Early Development: The Pragmatics of Action and Gestures
Authors: Rodríguez Cintia
Published: August 2022

The position I take in this paper is that investigation of the construction and development of executive function (EF) and cognitive self-regulation must give children the opportunity to behave with initiative, as the agents they are. It must be based on children’s goal-directed behaviours and the challenges they face to achieve their own goals from the last third of the first year of life. It must consider children’s interests, the ecological validity of the situations, and the social context. Investigation into the origin and early development of cognitive self-regulation must be firmly anchored within a developmental framework. I will suggest that such a developmental framework is provided by the functional turn developed in the School of Geneva in the 1970s and its influence on the Pragmatics of the Object perspective. According to this pragmatic approach, actions and (private) gestures are central in the emergence and construction of EF.
A Esposa Divina de Amon em Assassin's Creed Origins - A Maldição dos Faraós: ressignificados e implicações
Authors: Kawaminami André Shinity
Published: August 2022

O jogo Assassin’s Creed: Origins pode ser considerado um dos grandes sucessos da Ubisoft. O lançamento de sua expansão em 2018 chamada “A Maldição dos Faraós” contribuiu ainda mais para a popularização do game, trazendo aos jogadores mais informações e reconstituições de cenários e personagens históricos do Egito Antigo. Por meio de uma análise mais voltada ao campo da História e não se atendo apenas ao delineamento de anacronismos e imprecisões históricas, este artigo tem como objetivo analisar as esposas divinas de Amon presentes em “A Maldição dos Faraós” para compreender os ressignificados sobre o ofício dessas sacerdotisas e suas implicações para o público em geral (particularmente o de jogadores).
Presentes entre irmãos – uma abordagem antropológica (Período de Amarna, Século XIV a.C.)
Authors: Ferreira Renato de Carvalho
Published: August 2022

No Período de Amarna (século XIV a.C.), o Egito manteve íntimas relações diplomáticas com seus vizinhos do Oriente Médio (Mitani, Babilônia, Assíria e Hati). Esses contatos são conhecidos por nós através das Cartas de Amarna (EA) descobertas no sítio de Telel Amarna (antiga Aquetatom), no Egito. Protocolarmente, as cortes enviavam emissários às cortes vizinhas carregando consigo mensagens, escritas em tabletes de argila, e presentes. Os presentes eram sempre esperados pela corte destinatária e sua ausência, caso ocorresse, poderia gerar reclamações. O sistema, imperativamente, demandava a submissão de presentes, mas não são poucos os casos nos quais um dos parceiros falhavam com o compromisso de envio. O presente artigo discute o que estas falhas podem revelar acerca das relações desses reis e como elas elucidam as características desse sistema diplomático.
Quantitative anatomy or macroscopic parameters of compression wood of Picea abies (L.) H. Karst.? Defining the optimal parameters for dendrogeomorphic purposes
Authors: Wiśniewská Kristýna , Šilhán Karel
Published: August 2022

The quantification of the intensities of tree growth responses to the impact of geomorphic processes is a modern research trend in dendrogeomorphology. It enables a more sensitive assessment of the activity of the studied geomorphic process compared to the traditional use of growth disturbances. The advanced definitions of individual intensity classes of growth disturbances are based exclusively on macroscopic observations. This study evaluates the possibility of anatomical quantification of compression wood (CW) intensity in the case of common spruce (Picea abies (L.) Karst.) and compares it with subjective macroscopic evidence of CW with respect to stem tilting intensity. In total, 25 disturbed (tilted) individuals of P. abies occupying a landslide active during July 1997 were sampled, and 21 of them were analysed. The intensity of external disturbance (stem tilting) was compared against the macroscopic (intensity and duration) and microscopic (quantitative change of the tracheid lumen area and the cell wall proportion) parameters of compression wood suitable for practical application in common dendrogeomorphic analysis. Generally, the macroscopic indices of CW were strongly correlated with stem tilting. The intensity of the anatomical growth response was stronger in the earlywood zone than in the latewood zone. Nevertheless, their dependence on stem tilting was not detected. Results suggest that CW classification based on the quantification of anatomical changes is not possible for dendrogeomorphic purposes. Nevertheless, based on the obtained results, the present study suggests preferring the most intensively tilted trees during future dendrogeomorphic research to obtain the most intensive macroscopic and subjective observable anatomical evidence for studying compression wood.
Taxonomic notes and range extension of the monospecific genus Ramudaria (Lophocoleaceae, Marchantiophyta) endemic to India
Authors: XU HAO , XU JING-JING , MA XIAO-YING , ZHU RUI-LIANG
Published: August 2022

Ramudaria is a monospecific genus well-characterized by the longitudinal, serially arranged lamelliform strips on the surface of the stem. This character seems to be unique amongst the leafy liverworts. Ramudaria lamellicaulis is so far known only from Arunachal Pradesh and Sikkim in the Eastern Himalaya, India. The species is reported here for the first time for China. The locality recorded here for China is the northernmost and highest in altitude. A description and illustrations of R. lamellicaulis based on the Chinese specimen are provided, along with a distribution map. A discussion about the status of such a morphologically remarkable genus is presented and an author citation of Ramudaria is corrected.
A novel taxon of the genus Ischaemum (Poaceae: Andropogoneae: Ischaeminae) from southern Western Ghats, Kerala, India
Authors: JABEENA MANJAKULAM KHADHERSHA , NITHYA VADASSERY MADHANAN , PRABHUKUMAR KONICKAL MAMBETTA , ATHIRA SUBRAMANIAN , HAREESH VADAKKOOT SANKARAN , MAYA CHANDRASEKHARAN NAIR
Published: August 2022

Ischaemum sunilii, a new grass species from Nelliyampathy hills of southern Western Ghats, Kerala, India, is described and illustrated. The new species is allied to I. rangacharianum, but differs in many attributes. Description of the new species with distribution, ecology and comparison with its allied taxa are provided.