bluuebunny/crossref_metadata_2025 huggingface dataset:
Supplementary Figure S4 from Randomized Placebo-Controlled, Biomarker-Stratified Phase Ib Microbiome Modulation in Melanoma: Impact of Antibiotic Preconditioning on Microbiome and Immunity
Authors: Glitza Isabella C. , Seo Yongwoo David , Spencer Christine N. , Wortman Jennifer R. , Burton Elizabeth M. , Alayli Farah A. , Loo Christopher P. , Gautam Shikha , Damania Ashish , Densmore Julie , Fairchild Justin , Cabanski Christopher R. , Wong Matthew C. , Peterson Christine B. , Weiner Brian , Hicks Nathan , Aunins John , McChalicher Christopher , Walsh Emily , Tetzlaff Michael T. , Hamid Omid , Ott Patrick A. , Boland Genevieve M. , Sullivan Ryan J. , Grossmann Kenneth F. , Ajami Nadim J. , LaVallee Theresa , Henn Matthew R. , Tawbi Hussein A. , Wargo Jennifer A.
Published: July 2024

Progression-free survival in a retrospective melanoma immunotherapy cohort by baseline Ruminococcaceae status
Supplementary Figure S21 from Randomized Placebo-Controlled, Biomarker-Stratified Phase Ib Microbiome Modulation in Melanoma: Impact of Antibiotic Preconditioning on Microbiome and Immunity
Authors: Glitza Isabella C. , Seo Yongwoo David , Spencer Christine N. , Wortman Jennifer R. , Burton Elizabeth M. , Alayli Farah A. , Loo Christopher P. , Gautam Shikha , Damania Ashish , Densmore Julie , Fairchild Justin , Cabanski Christopher R. , Wong Matthew C. , Peterson Christine B. , Weiner Brian , Hicks Nathan , Aunins John , McChalicher Christopher , Walsh Emily , Tetzlaff Michael T. , Hamid Omid , Ott Patrick A. , Boland Genevieve M. , Sullivan Ryan J. , Grossmann Kenneth F. , Ajami Nadim J. , LaVallee Theresa , Henn Matthew R. , Tawbi Hussein A. , Wargo Jennifer A.
Published: July 2024

Overview of exploratory correlative specimen availability
Supplementary Figure S2 from Randomized Placebo-Controlled, Biomarker-Stratified Phase Ib Microbiome Modulation in Melanoma: Impact of Antibiotic Preconditioning on Microbiome and Immunity
Authors: Glitza Isabella C. , Seo Yongwoo David , Spencer Christine N. , Wortman Jennifer R. , Burton Elizabeth M. , Alayli Farah A. , Loo Christopher P. , Gautam Shikha , Damania Ashish , Densmore Julie , Fairchild Justin , Cabanski Christopher R. , Wong Matthew C. , Peterson Christine B. , Weiner Brian , Hicks Nathan , Aunins John , McChalicher Christopher , Walsh Emily , Tetzlaff Michael T. , Hamid Omid , Ott Patrick A. , Boland Genevieve M. , Sullivan Ryan J. , Grossmann Kenneth F. , Ajami Nadim J. , LaVallee Theresa , Henn Matthew R. , Tawbi Hussein A. , Wargo Jennifer A.
Published: July 2024

Spiderplot demonstrating change of lesion size from pre-treatment baseline
Supplementary Figure S19 from Randomized Placebo-Controlled, Biomarker-Stratified Phase Ib Microbiome Modulation in Melanoma: Impact of Antibiotic Preconditioning on Microbiome and Immunity
Authors: Glitza Isabella C. , Seo Yongwoo David , Spencer Christine N. , Wortman Jennifer R. , Burton Elizabeth M. , Alayli Farah A. , Loo Christopher P. , Gautam Shikha , Damania Ashish , Densmore Julie , Fairchild Justin , Cabanski Christopher R. , Wong Matthew C. , Peterson Christine B. , Weiner Brian , Hicks Nathan , Aunins John , McChalicher Christopher , Walsh Emily , Tetzlaff Michael T. , Hamid Omid , Ott Patrick A. , Boland Genevieve M. , Sullivan Ryan J. , Grossmann Kenneth F. , Ajami Nadim J. , LaVallee Theresa , Henn Matthew R. , Tawbi Hussein A. , Wargo Jennifer A.
Published: July 2024

Peripheral Treg populations of interest by baseline Ruminococcaceae status prior to initiating anti-PD1 therapy
Supplementary Figure S17 from Randomized Placebo-Controlled, Biomarker-Stratified Phase Ib Microbiome Modulation in Melanoma: Impact of Antibiotic Preconditioning on Microbiome and Immunity
Authors: Glitza Isabella C. , Seo Yongwoo David , Spencer Christine N. , Wortman Jennifer R. , Burton Elizabeth M. , Alayli Farah A. , Loo Christopher P. , Gautam Shikha , Damania Ashish , Densmore Julie , Fairchild Justin , Cabanski Christopher R. , Wong Matthew C. , Peterson Christine B. , Weiner Brian , Hicks Nathan , Aunins John , McChalicher Christopher , Walsh Emily , Tetzlaff Michael T. , Hamid Omid , Ott Patrick A. , Boland Genevieve M. , Sullivan Ryan J. , Grossmann Kenneth F. , Ajami Nadim J. , LaVallee Theresa , Henn Matthew R. , Tawbi Hussein A. , Wargo Jennifer A.
Published: July 2024

Differences in baseline peripheral immune cell populations by response and baseline Ruminococcaceae levels
Supplementary Figure S14 from Randomized Placebo-Controlled, Biomarker-Stratified Phase Ib Microbiome Modulation in Melanoma: Impact of Antibiotic Preconditioning on Microbiome and Immunity
Authors: Glitza Isabella C. , Seo Yongwoo David , Spencer Christine N. , Wortman Jennifer R. , Burton Elizabeth M. , Alayli Farah A. , Loo Christopher P. , Gautam Shikha , Damania Ashish , Densmore Julie , Fairchild Justin , Cabanski Christopher R. , Wong Matthew C. , Peterson Christine B. , Weiner Brian , Hicks Nathan , Aunins John , McChalicher Christopher , Walsh Emily , Tetzlaff Michael T. , Hamid Omid , Ott Patrick A. , Boland Genevieve M. , Sullivan Ryan J. , Grossmann Kenneth F. , Ajami Nadim J. , LaVallee Theresa , Henn Matthew R. , Tawbi Hussein A. , Wargo Jennifer A.
Published: July 2024

Targeted MetaCyc imputed pathway analysis
Supplementary Figure S1 from Randomized Placebo-Controlled, Biomarker-Stratified Phase Ib Microbiome Modulation in Melanoma: Impact of Antibiotic Preconditioning on Microbiome and Immunity
Authors: Glitza Isabella C. , Seo Yongwoo David , Spencer Christine N. , Wortman Jennifer R. , Burton Elizabeth M. , Alayli Farah A. , Loo Christopher P. , Gautam Shikha , Damania Ashish , Densmore Julie , Fairchild Justin , Cabanski Christopher R. , Wong Matthew C. , Peterson Christine B. , Weiner Brian , Hicks Nathan , Aunins John , McChalicher Christopher , Walsh Emily , Tetzlaff Michael T. , Hamid Omid , Ott Patrick A. , Boland Genevieve M. , Sullivan Ryan J. , Grossmann Kenneth F. , Ajami Nadim J. , LaVallee Theresa , Henn Matthew R. , Tawbi Hussein A. , Wargo Jennifer A.
Published: July 2024

Intended study schema and CONSORT diagram
Supplementary Table S5 from Efficacy and Safety of Adagrasib plus Cetuximab in Patients with KRASG12C-Mutated Metastatic Colorectal Cancer
Authors: Yaeger Rona , Uboha Nataliya V. , Pelster Meredith S. , Bekaii-Saab Tanios S. , Barve Minal , Saltzman Joel , Sabari Joshua K. , Peguero Julio A. , Paulson Andrew Scott , Jänne Pasi A. , Cruz-Correa Marcia , Anderes Kenna , Velastegui Karen , Yan Xiaohong , Der-Torossian Hirak , Klempner Samuel J. , Kopetz Scott E.
Published: July 2024

Table S5. Summary of TRAEs with adagrasib monotherapy in previously treated patients with KRASG12C-mutated unresectable or metastatic CRC.
Supplementary Table 8 from The Pan-RAF–MEK Nondegrading Molecular Glue NST-628 Is a Potent and Brain-Penetrant Inhibitor of the RAS–MAPK Pathway with Activity across Diverse RAS- and RAF-Driven Cancers
Authors: Ryan Meagan B. , Quade Bradley , Schenk Natasha , Fang Zhong , Zingg Marshall , Cohen Steven E. , Swalm Brooke M. , Li Chun , Özen Ayşegül , Ye Chaoyang , Ritorto Maria Stella , Huang Xin , Dar Arvin C. , Han Yongxin , Hoeflich Klaus P. , Hale Michael , Hagel Margit
Published: July 2024

Global proteomics data
Supplementary Figure S2 from Efficacy and Safety of Adagrasib plus Cetuximab in Patients with KRASG12C-Mutated Metastatic Colorectal Cancer
Authors: Yaeger Rona , Uboha Nataliya V. , Pelster Meredith S. , Bekaii-Saab Tanios S. , Barve Minal , Saltzman Joel , Sabari Joshua K. , Peguero Julio A. , Paulson Andrew Scott , Jänne Pasi A. , Cruz-Correa Marcia , Anderes Kenna , Velastegui Karen , Yan Xiaohong , Der-Torossian Hirak , Klempner Samuel J. , Kopetz Scott E.
Published: July 2024

Supplementary Figure S2: Efficacy outcomes with adagrasib monotherapy in previously treated patients with KRASG12C-mutated unresecable or metastatic CRC.
Supplementary Table 7 from The Pan-RAF–MEK Nondegrading Molecular Glue NST-628 Is a Potent and Brain-Penetrant Inhibitor of the RAS–MAPK Pathway with Activity across Diverse RAS- and RAF-Driven Cancers
Authors: Ryan Meagan B. , Quade Bradley , Schenk Natasha , Fang Zhong , Zingg Marshall , Cohen Steven E. , Swalm Brooke M. , Li Chun , Özen Ayşegül , Ye Chaoyang , Ritorto Maria Stella , Huang Xin , Dar Arvin C. , Han Yongxin , Hoeflich Klaus P. , Hale Michael , Hagel Margit
Published: July 2024

RNAseq DEG data
Supplementary Appendix from Efficacy and Safety of Adagrasib plus Cetuximab in Patients with KRASG12C-Mutated Metastatic Colorectal Cancer
Authors: Yaeger Rona , Uboha Nataliya V. , Pelster Meredith S. , Bekaii-Saab Tanios S. , Barve Minal , Saltzman Joel , Sabari Joshua K. , Peguero Julio A. , Paulson Andrew Scott , Jänne Pasi A. , Cruz-Correa Marcia , Anderes Kenna , Velastegui Karen , Yan Xiaohong , Der-Torossian Hirak , Klempner Samuel J. , Kopetz Scott E.
Published: July 2024

Supplementary Appendix: additional Methods information
Supplementary Methods from The Pan-RAF–MEK Nondegrading Molecular Glue NST-628 Is a Potent and Brain-Penetrant Inhibitor of the RAS–MAPK Pathway with Activity across Diverse RAS- and RAF-Driven Cancers
Authors: Ryan Meagan B. , Quade Bradley , Schenk Natasha , Fang Zhong , Zingg Marshall , Cohen Steven E. , Swalm Brooke M. , Li Chun , Özen Ayşegül , Ye Chaoyang , Ritorto Maria Stella , Huang Xin , Dar Arvin C. , Han Yongxin , Hoeflich Klaus P. , Hale Michael , Hagel Margit
Published: July 2024

Supplementary methods with detailed protein production, mass spectrometry, in vivo, and in vitro methodology
Botensilimab, an Fc-Enhanced Anti–CTLA-4 Antibody, Is Effective against Tumors Poorly Responsive to Conventional Immunotherapy
Authors: Chand Dhan , Savitsky David A. , Krishnan Shanmugarajan , Mednick Gabriel , Delepine Chloe , Garcia-Broncano Pilar , Soh Kah Teong , Wu Wei , Wilkens Margaret K. , Udartseva Olga , Vincent Sylvia , Joshi Bishnu , Keith Justin G. , Manrique Mariana , Marques Marilyn , Tanne Antoine , Levey Daniel L. , Han Haiyong , Ng Serina , Ridpath Jackson , Huber Olivia , Morin Benjamin , Galand Claire , Bourdelais Sean , Gombos Randi B. , Ward Rebecca , Qin Yu , Waight Jeremy D. , Costa Matthew R. , Sebastian-Yague Alvaro , Rudqvist Nils-Petter , Pupecka-Swider Malgorzata , Venkatraman Vignesh , Slee Andrew , Patel Jaymin M. , Grossman Joseph E. , Wilson Nicholas S. , Von Hoff Daniel D. , Stebbing Justin , Curiel Tyler J. , Buell Jennifer S. , O’Day Steven J. , Stein Robert B.
Published: July 2024

Conventional immune checkpoint inhibitors (ICI) targeting cytotoxic T-lymphocyte antigen 4 (CTLA-4) elicit durable survival but primarily in patients with immune-inflamed tumors. Although the mechanisms underlying response to anti–CTLA-4 remain poorly understood, Fc-gamma receptor (FcγR) IIIA coengagement seems critical for activity, potentially explaining the modest clinical benefits of approved anti–CTLA-4 antibodies. We demonstrate that anti–CTLA-4 engineered for enhanced FcγR affinity leverages FcγR-dependent mechanisms to potentiate T-cell responsiveness, reduce intratumoral regulatory T cells, and enhance antigen-presenting cell activation. Fc-enhanced anti–CTLA-4 promoted superior efficacy in mouse models and remodeled innate and adaptive immunity versus conventional anti–CTLA-4. These findings extend to patients treated with botensilimab, an Fc-enhanced anti–CTLA-4 antibody, with clinical activity across multiple poorly immunogenic and ICI treatment–refractory cancers. Efficacy was independent of tumor neoantigen burden or FCGR3A genotype. However, FCGR2A and FCGR3A expression emerged as potential response biomarkers. These data highlight the therapeutic potential of Fc-enhanced anti–CTLA-4 antibodies in cancers unresponsive to conventional ICI therapy.

Significance:

This study reveals that Fc-enhanced anti–CTLA-4 harnesses novel mechanisms to overcome the limitations of conventional anti–CTLA-4, effectively treating poorly immunogenic and treatment-refractory cancers. Our findings support the development of a new class of immuno-oncology agents, capable of extending clinical benefit to patients with cancers resistant to current immunotherapies.
Supplementary Figure S4 from Inhibition of Notch4 Using Novel Neutralizing Antibodies Reduces Tumor Growth in Murine Cancer Models by Targeting the Tumor Endothelium
Authors: Eng Jason W.-L. , Kato Yu , Adachi Yusuke , Swaminathan Bhairavi , Naiche L.A. , Vadakath Rahul , Sakamoto Yoshimasa , Nakazawa Youya , Tachino Sho , Ito Ken , Abe Takanori , Minoshima Yukinori , Hoshino-Negishi Kana , Ogasawara Hideaki , Kawakatsu Tomomi , Nishimura Miyuki , Katayama Masahiko , Shimizu Masashi , Tahara Kazuhiro , Sato Toshitaka , Suzuki Katsuhisa , Agarwala Kishan , Iwata Masao , Nomoto Kenichi , Ozawa Yoichi , Imai Toshio , Funahashi Yasuhiro , Matsui Junji , Kitajewski Jan
Published: July 2024

A-B, Growth curves of subcutaneous B16F10 (n=3) and orthotopic Py8119 tumors (n=3) implanted into C57BL/6 mice and treated twice weekly IV with 25 m/kg of E7011 until tumors reached roughly 200mm3. Treatment duration was 4 days for B16F10 and 10 days for Py8119. C, Dose response curve of Calu-6 xenografts implanted subcutaneously in nude mice and treated with either control IgG, 1mg/kg, 3mg/kg or 10mg/kg of E7011 IV for 8 days (n=8). D, Representative images of CD31 staining and Hoescht dye staining following treatment. E, Quantitation of Hoescht+ stained area over total area. All quantitation were normalized to the control IgG. Statistics by 2-way ANOVA for growth curves and t-test for perfusion studies; *p<0.05, **p<0.01, ***p<0.001.
Supplementary Figure S1 from Inhibition of Notch4 Using Novel Neutralizing Antibodies Reduces Tumor Growth in Murine Cancer Models by Targeting the Tumor Endothelium
Authors: Eng Jason W.-L. , Kato Yu , Adachi Yusuke , Swaminathan Bhairavi , Naiche L.A. , Vadakath Rahul , Sakamoto Yoshimasa , Nakazawa Youya , Tachino Sho , Ito Ken , Abe Takanori , Minoshima Yukinori , Hoshino-Negishi Kana , Ogasawara Hideaki , Kawakatsu Tomomi , Nishimura Miyuki , Katayama Masahiko , Shimizu Masashi , Tahara Kazuhiro , Sato Toshitaka , Suzuki Katsuhisa , Agarwala Kishan , Iwata Masao , Nomoto Kenichi , Ozawa Yoichi , Imai Toshio , Funahashi Yasuhiro , Matsui Junji , Kitajewski Jan
Published: July 2024

A, Binding curves determined by SPR of 6-3-A6 and E7011 to murine and cynomolgus monkey Notch4. B, Binding of 6-3-A6 and E7011 at increasing concentrations to transfected HEK293 cell lines overexpressing full length human, murine, and cynomolgus Notch4 as assessed by mean fluorescent intensity (MFI) using flow cytometry.
Figure 1 from Inhibition of Notch4 Using Novel Neutralizing Antibodies Reduces Tumor Growth in Murine Cancer Models by Targeting the Tumor Endothelium
Authors: Eng Jason W.-L. , Kato Yu , Adachi Yusuke , Swaminathan Bhairavi , Naiche L.A. , Vadakath Rahul , Sakamoto Yoshimasa , Nakazawa Youya , Tachino Sho , Ito Ken , Abe Takanori , Minoshima Yukinori , Hoshino-Negishi Kana , Ogasawara Hideaki , Kawakatsu Tomomi , Nishimura Miyuki , Katayama Masahiko , Shimizu Masashi , Tahara Kazuhiro , Sato Toshitaka , Suzuki Katsuhisa , Agarwala Kishan , Iwata Masao , Nomoto Kenichi , Ozawa Yoichi , Imai Toshio , Funahashi Yasuhiro , Matsui Junji , Kitajewski Jan
Published: July 2024

Development and validation of 6-3-A6 and E7011 as Notch4 inhibitors. A, Schematic of the immunizing epitope used to generate clone 6-3-A6. EGF, EGF repeats; Igk, immunoglobulin κ chain; SEAP, secreted embryonic alkaline phosphatase. B, Binding assay of the fully humanized E7011 and 6-3-A6 fused to human Fc for immobilization. Affinity to recombinant human Notch4 was calculated with surface plasmon resonance. C, Affinity of 6-3-A6 and E7011 to Raji cell lines generated to overexpress full-length human Notch1, Notch2, Notch3, and Notch4 (hNotch1 to 4, respectively). Binding was determined by MFI with flow cytometry analysis (n = 3). D, Luciferase reporter assay using a Notch4-ECD/Notch1-ICD-Gal4 fusion protein expressed in bEnd.3-immortalized ECs. Luminescence was measured with increasing concentrations of added E7011 or 6-3-A6. Statistical analysis performed with one-way ANOVA with the Dunnett multiple comparison test, plotted as average ± SEM; **, P < 0.01; ****, P < 0.0001.
Refluxing versus Non-Refluxing Ureteric Implantation in Continent Cutaneous Urinary Diversion: A Propensity-Scored Comparison regarding Long-Term Renal, Metabolic, and Functional Outcomes of Patients with Ileocecal Pouch
Authors: Schwinger Marcel , Seitz Anna Katharina , Kübler Hubert , Kocot Arkadius , Riedmiller Hubertus , Kalogirou Charis
Published: July 2024

Introduction: Studies comparing refluxing versus non-refluxing ureteric implantation in continent cutaneous urinary diversion (CCUD) are scarce and often characterized by heterogeneous study populations. This work therefore aimed at comparing both techniques regarding long-term outcomes in a propensity-scored approach. Methods: We identified n = 19 patients, totaling n = 38 renal units (RU), who underwent CCUD surgery at our hospital out of a pool of 120 patients. Of these 38 RU, 27 RU were implanted via refluxing ureteric implantation utilizing various procedures due to special intraoperative circumstances (short ureters, damage due to radiation). In terms of preoperative renal function, a comorbidity index (Age-Adjusted Charlson Comorbidity Index [ACCI]), and gender, we compared them to n = 38 patients with a total of 76 RU with non-refluxing ureteric implantation in all RU (1:2 matching). The mean follow-up was 56 (IQR: 23–112) months. Results: Long-term renal function was comparable in CCUD patients receiving refluxing versus non-refluxing ureteric implantation (estimated glomerular filtration rate: 63.11 mL/min vs. 71.7 mL/min, p = 0.22) with an average decline of 17.4 mL/min and 13.69 mL/min during the follow-up period, respectively. Also, the rate of new-onset chronic kidney disease (CKD) (both 15%, p = 1), the need for alkalizing medication, or the number of pyelonephritis episodes did not significantly differ between the groups. In Cox regression analysis, ACCI was the single most predictive parameter for the development of new-onset CKD (HR: 1.71 [1.10–2.66], p = 0.0167). None of the RU in the refluxing group needed revisional surgery concerning the ureterointestinal anastomosis, whereas 7 RU of the non-refluxing group did. Conclusions: Our study confirms that refluxing ureteric implantation in CCUDs is a valid and safe procedure regarding long-term renal, metabolic and functional outcomes. Our data also suggest that patients should be counseled according to their comorbidities regarding long-term renal function.
Conventional Excisional Haemorrhoidectomy versus Transanal Haemorrhoidal Dearterialization for Haemorrhoids: A Systematic Review and Meta-Analysis
Authors: Jee Juliana , O’Connell Lauren Vourneen , Kaur Ishapreet , Sahebally Shaheel Mohammad
Published: July 2024

Introduction: Although effective, conventional excisional haemorrhoidectomy (CEH) is associated with significant postoperative pain. Novel techniques such as transanal haemorrhoidal dearterialization (THD) are suggested to reduce pain but may result in higher recurrence rates. We aimed to compare short- and long-term outcomes of CEH and THD in the present meta-analysis. Methods: A PRISMA-compliant meta-analysis was performed, searching PubMed, Embase, and CENTRAL databases for randomised controlled trials (RCTs) from 1995 to December 2022. The primary objective was recurrence. Secondary objectives included complication rates, length of stay (LOS), operative time, and time to return to baseline. Random-effects models were used to calculate pooled effect size estimates. Subgroup analysis was also performed. Results: A total of 6 RCTs encompassing 465 patients were captured. There were 142 (59%) males in the CEH group and 129 (54%) in the THD group. On random-effects analysis, THD had a higher recurrence rate (odds ratio = 2.76, 95% confidence interval [CI] = 1.03–7.38, p = 0.04) albeit a shorter return to baseline compared to CEH (mean difference = −14.05 days, 95% CI = −20.38 to −7.72, p < 0.0001). There were no differences in bleeding (p = 0.12), urinary retention (p = 0.97), incontinence (p = 0.41), anal stenosis (p = 0.19), thrombosed residual haemorrhoids (p = 0.16), operating time (p = 0.19), or LOS (p = 0.22). Results remained similar on subgroup analysis. Conclusions: CEH is associated with lower recurrence but similar complication rates to THD, although patients take longer to return to baseline function postoperatively.
Serum Soluble Suppression of Tumorigenicity-2 Levels Predict Cardiovascular Events in Patients Undergoing Incident Peritoneal Dialysis: A Prospective Cohort Study
Authors: Zhang Yunyun , Xu Qijiang , Wu Xiaofang , Pu Li , Zang Zhiyun , Xia Xiaoxiao , Ma Niya , Li Zi
Published: July 2024

Introduction: Biomarkers are urgently required to identify peritoneal dialysis (PD) patients at risk of cardiovascular (CV) events. This study aimed to investigate the predictive value of soluble suppression of tumorigenicity-2 (sST2) for CV events in patients undergoing incident PD. Methods: In this prospective cohort study, incident PD patients were enrolled. Blood samples to measure sST2 levels were obtained before PD catheter implantation. The patients underwent a standard peritoneal equilibration test (PET) after initiation of PD for 4–6 weeks. The sST2 levels in both serum and dialysate were determined using enzyme-linked immunosorbent assay. CV events were recorded during the follow-up period. Results: A total of 137 patients were enrolled. During the follow-up period of 17.3 months, 49 (35.76%) patients experienced CV events. When patients were dichotomized based on the median values and the calculated cutoff values of sST2, the higher sST2 group had 2.980- and 3.048-fold increased risks of CV events, respectively, when compared with the lower sST2 group. Moreover, the prognostic value of sST2 remained significant as a continuous variable (per 1 standard deviation increase, hazard ratio [HR] = 1.037, 95% confidence interval [CI] 1.010–1.066, p = 0.008). N-terminal pro-brain natriuretic peptide (NT-proBNP) levels were found to indicate a higher risk only when dichotomized based on the calculated cutoff values. Furthermore, serum sST2 and NT-proBNP levels simultaneously above the calculated cutoff values were associated with a higher risk of CV events (HR = 3.398, 95% CI 1.813–6.367, p < 0.001). Conclusion: Baseline serum sST2 level is an independent predictor of the risk of CV events in patients receiving incident PD, and in combination with NT-proBNP level, it can provide a more accurate predictive value.
There Is No Direct Causal Relationship Between Coronary Artery Disease and Alzheimer Disease: A Bidirectional Mendelian Randomization Study
Authors: Zhong Aifang , Tan Yejun , Liu Yaqiong , Chai Xiangping , Peng Weijun
Published: July 2024

Background

The association between poor cardiovascular health and cognitive decline as well as dementia progression has been inconsistent across studies. This study used Mendelian randomization (MR) to investigate the causal relationship between Alzheimer disease (AD), circulating levels of total‐tau, and coronary artery disease (CAD).

Methods and Results

This study used MR to investigate the causal relationship between AD or circulating levels of total‐tau and CAD, including ischemic heart disease, myocardial infarction, coronary heart disease, coronary atherosclerosis, and heart failure. The primary analysis used the inverse‐variance weighted method, with pleiotropy and heterogeneity assessed using MR‐Egger regression and the
Q
statistic. The overall results of the MR analysis indicated that AD did not exhibit a causal effect on heart failure (odds ratio [OR], 0.969 [95% CI, 0.921–1.018];
P
=0.209), myocardial infarction (OR, 0.972 [95% CI, 0.915–1.033];
P
=0.359), ischemic heart disease (OR, 1.013 [95% CI, 0.949–1.082];
P
=0.700), coronary heart disease (OR, 1.005 [95% CI, 0.937–1.078];
P
=0.881), or coronary atherosclerosis (OR, 0.987 [95% CI, 0.926–1.052];
P
=0.690). No significant causal effect of CAD was observed on AD in the reverse MR analysis. Additionally, our findings revealed that CAD did not influence circulating levels of total‐tau, nor did circulating levels of total‐tau increase the risk of CAD. Sensitivity analysis and assessment of horizontal pleiotropy suggested that these factors did not distort the causal estimates.

Conclusions

The findings of this study indicate the absence of a direct causal relationship between AD and CAD from a genetic perspective. Therefore, managing the 2 diseases should be more independent and targeted. Concurrently, investigating the mechanism underlying their comorbidity may not yield meaningful insights for advancing treatment strategies.
Ambient Air Pollution Exposure and Adverse Outcomes Among Medicare Beneficiaries With Heart Failure
Authors: Mentias Amgad , Desai Milind Y. , Pandey Ambarish , Motairek Issam , Moudgil Rohit , Albert Chonyang , Deo Salil V. , Brook Robert D. , Menon Venu , Rajagopalan Sanjay , Al‐Kindi Sadeer
Published: July 2024

Background

Exposure to fine particulate matter (<2.5 um, particulate matter with an aerodynamic diameter <2.5 microns [PM
2.5
]) has been implicated in atherogenesis. Limited data in animal studies suggest that PM
2.5
exposure leads to myocardial fibrosis and increased incidence of heart failure (HF). Whether PM
2.5
is associated with adverse outcomes in patients with preexisting HF has not been widely studied.

Methods and Results

In this retrospective cohort study, Medicare patients hospitalized with first HF between 2013 and 2020 were identified from the Medicare Provider Analysis and Review Part A 100% files. Patients were linked with integrated estimates of ambient PM
2.5
obtained at 1×1 km using the zip code of participants' residence. The study outcomes were all‐cause death, HF, and all‐cause readmissions burden. A total of 2 599 525 patients were included in this study, with 6 321 731 person‐years of follow‐up. Mean PM
2.5
was 7.3±1.7 μg/m
3
. Each interquartile range of PM
2.5
was associated with 0.9% increased hazard of all‐cause death, 4.5% increased hazard of first HF readmission, 3.1% increased risk of HF hospitalization burden, and 5.2% increase in all‐cause readmission burden, after adjusting for 11 sociodemographic and medical factors. Subgroup analyses showed that the effects were more pronounced at levels <7 μg/m
3
and in patients aged <75 years, Asians, and those residing in rural areas.

Conclusions

Ambient air pollution is associated with higher risk of adverse events in Medicare beneficiaries with established HF. These associations persist below the National Air Quality Standards (12 μg/m
3
), supporting that no threshold effect exists for health effects of air pollution exposure.
Lojistikte Sürdürülebilirlik Performansı: BIST Ulaştırma ve Depolama Sektörü Analizi
Authors: Özkan Özen Yeşim Deniz
Published: July 2024

Lojistik sektöründe sürdürülebilirlik performansı çevresel, sosyal ve ekonomik ektileri itibariyle kritik bir konudur ve sürdürülebilirlik performansının değerlendirilmesi işletmelerin günümüz küreselleşen dünyasında varlıklarının devamlılığını sağlayabilmeleri için stratejik önem taşımaktadır. Bu çalışmanın amacı lojistikte sürdürülebilirlik performans değerlendirmesinde kullanılacak göstergeleri ortaya koymak ve BİST Ulaştırma ve Depolama sektöründe yer alan şirketlerin sürdürülebilirlik performanslarını değerlendirerek sektörel bir analiz gerçekleştirmektir. Çalışmada yöntem olarak çok kriterli karar verme yöntemlerinden Entropi ve TOPSİS birlikte kullanılmıştır. Uygulamada, sektörde yer alan 9 şirket, ekonomik, çevresel ve sosyal konulardan oluşan 7 sürdürülebilirlik performansı göstergesi açısından değerlendirilmiştir. Çalışma sonucunda, ekonomik sürdürülebilirlik göstergelerinin yüksek ağırlığa sahip olduğu, şirket büyüklüğü ile sürdürülebilirlik performansı arasında aynı yönlü bir ilişki olduğu ve sürdürülebilirlik performansı en yüksek olan şirketlerin havayolu taşımacılığı alanında olduğu ortaya çıkmıştır.
Conflict Resolution through Indigenous Knowledge Systems
Authors: Abdo Mohammedawol Reshad
Published: July 2024

Indigenous knowledge is the local knowledge that is unique to a given culture or society. It is the basis for local decision-making in agriculture, medicine, food education, environmental management, craft skills, linguistics and conflict management. The study explored mengehacha, an indigenous system of conflict resolution among the Gumuz people in northwest Ethiopia, which aims to restore peace and harmony within the community when conflicts result from natural resource competition, exchange marriage, clan-based conflict and theft. Data was collected through semi-structured interviews, focus group discussions, non-participatory observation and document analysis, and analysed qualitatively. The indigenous mechanisms of conflict resolution were found to be relatively participatory and supplementary to the state justice system. It is recommended that indigenous systems of conflict management be supported and given equal treatment with the modern court system and that exchange marriage be curbed, since it is becoming a trigger for conflict eruption among the Gumuz.
The Identity, Etymology, and Material Context of סֹחֶרֶת in Esther 1:6
Authors: Ayil Ephraim S.
Published: July 2024

The hapax legomenon סֹחֶרֶת (sōḥereth) has eluded identification. Comparison with Ancient Egyptian ṯḥnt “faience, blue chalcedony” is phonologically plausible. “Faience” does indeed match the material evidence of the Susan palace.
Creating Community through Church-based Pollinator Gardening
Authors: Dohe Carrie B.
Published: July 2024

Bees for Peace promotes pollinator protection by establishing blooming feeding sites for bees and other pollinators on the grounds of houses of worship. In Canada, the project’s primary aim was to educate people about native bees, invoking positive feelings that moved people to protect these relatively unfamiliar creatures. To do so, I developed fun, educational games and talks on the cultural history of bees, which I presented at numerous churches in the Greater Toronto Area. Despite ongoing challenges posed by the COVID-19 pandemic, the project and its student researchers were able to partner with two churches to plant pollinator gardens. The educational activities that accompanied the care and maintenance of these gardens resulted in individuals in and around the churches experiencing an expanded sense of community as well as a heightened awareness of native pollinators and the desire to protect them.
“Therefore I Say, Mary”
Authors: Parkhouse Sarah
Published: July 2024

The recently published P.Oxy. 5577 bears such striking similarities to the Gospel of Mary that this article argues that it may be from the missing pages in which Mary recalls her vision of Jesus and their private conversation. By examining the shared themes of cosmology and eschatology, incarnation and divine goodness, baptism and salvation, Jesus appearing as and through the νοῦς, and the privileged role of Mary, this article argues that we see a continuous teaching from the beginning of the extant Coptic Gos. Mary, through the Greek fragments including P.Oxy. 5577, to the end of the gospel. Although P.Oxy. 5577 cannot definitively be identified as Gos. Mary, the correlations are enough to take the suggestion of its likelihood seriously.
Triads, Groups, and the Text of Jude 22–23
Authors: Prothro James B.
Published: July 2024

The text of Jude 22–23 is notoriously difficult and continually disputed. While many now acknowledge the antiquity and external evidence in favor of the shortest, two-clause reading found in 𝔓⁷² and other sources, it is often argued that a longer reading with three clauses (printed in the NA/UBS) has greater intrinsic probability owing to Jude’s triadic style. Recent proponents of the longer reading also argue its plausibility within Jude’s argumentation and the “groups” addressed therein. The present article defends and aims to enhance the probability of the shortest reading on internal grounds. In particular, this article shows that this reading fits Jude’s triadic style and Jude’s call for the “beloved” to exercise mercy on the “disputers” with particular caution.
Social fish use different submission signals depending on spatial position
Authors: Reddon Adam R. , Richardson Christian , Jose Amy , Frommen Joachim G. , Swaney William T.
Published: July 2024

Animals often possess multiple distinct threat signals which indicate their level of aggressive motivation or resource holding potential. In contrast, the diversity of submission signals is considerably lower. Still, some social species exhibit multiple distinct submission signals which could have different strategic functions or serve to enhance signal transmission. In the current study, we examine submission signalling in the daffodil cichlid (Neolamprologus pulcher), a cooperatively breeding fish which produces two distinct submission signals: a tail quiver, and a head-up posture. Observing interactions within stable social groups revealed that submission signal selection depends on the location of the interaction, with tail quivers being preferentially displayed near the substrate, and head-up postures being deployed when the interaction takes place further away from the substrate. Our findings suggest that variation in submission signalling in daffodil cichlids may serve to enhance signal transmission across spatial contexts rather than to convey distinct information.
Vulnerable Group Theory of Financial Inclusion
Authors: Ozili Peterson K.
Published: July 2024

In this article, I propose the vulnerable group theory of financial inclusion. The theory begins with the premise that vulnerable people are often left behind in society, they suffer the most from economic hardship and crises, and they are at risk of being excluded from the formal financial sector. The theory therefore proposes that financial inclusion efforts should be targeted at all vulnerable people and groups in society. Bringing vulnerable people into the formal financial sector will give them access to available formal financial services, which they can use to earn income and acquire assets that they can use to take themselves out of the vulnerability bracket. The study also identifies the vulnerable groups in need of financial inclusion and proposes a vulnerability grid. Several avenues to expand the theory are suggested.
New Hellenistic Coin Finds from the Baysun and Kugitang Piedmonts, Southern Uzbekistan (season 2018)
Authors: Stančo Ladislav , Shaydullaev Shapulat , Militký Jiří , Kmošek Matěj , Bek Tomáš
Published: July 2024

The article presents assemblage of Seleucid and Greco-Bactrian coins found by the Czech-Uzbek archaeological expedition in the frame of a sampling metal detector survey in the upper reaches of Sherabad Darya, from the sites of the Darband Wall, Daganajam, Kurganzol and Iskandar Tepa in 2018. Sixteen specimens, of both silver and copper alloys, which were determined including a very rare Seleukos I (?) coin are assessed not only from the numismatic and historical point of view, but also analysed in terms of elemental composition.
Young Scientists and Model Children
Authors: Brzycki Melissa A.
Published: July 2024

During the Great Leap Forward (1958–1961), the state attempted to rapidly transform the country into a socialist, industrial powerhouse, necessitating the mobilisation of all members of society, including children. This article demonstrates that during the Great Leap Forward in particular, periodicals, storybooks, and newspaper stories portrayed children as independent problem-solvers and political actors, who often acted outside of, and sometimes in defiance of, adult authority. However, during this period, in daily life, teachers, parents, and Young Pioneer counsellors rewarded children for many aspects of the same behaviour as in the early years of the PRC: studying hard, helping one’s classmates, supporting the teacher, doing chores at home, and being kind and obedient to adults and authority figures. Thus, the heroic child of national media and the obedient child of daily life diverged significantly during the Great Leap Forward.
Madness and the Apostle: Paul’s Jewishness in the Euthalian Prologue to the Letters of Paul and in the Writings of John Chrysostom
Authors: Drake Luke
Published: July 2024

The Euthalian Prologue to the Letters of Paul is found in hundreds of late ancient and medieval editions of the Pauline corpus, presenting readers with a prefatory biography of the apostle that both aligns and departs from canonical traditions. Notably, the Prologue depicts Paul’s violence against early Christian assemblies as a manifestation of Jewish μανία, triggered by prophetic foresight and healed by Christ on the road to Damascus. Previous studies primarily examine the Prologue’s connection to canonical sources. This article explores its relationship with other late ancient expressions of Paul’s life. It argues specifically that the Prologue’s depiction of Paul has been shaped – either directly or indirectly – by the writings of John Chrysostom, based on otherwise unique shared thematic elements. Its findings contribute to our understanding of the Prologue’s nebulous origins, its rhetorical objectives, and Chrysostom’s already massive impact on the reception of Pauline literature and tradition in the late ancient and medieval periods.
The Twilight of the Law of the Fairs: Inventing International Cooperation on Bankruptcies in Early Modern Europe (Lyon, 1660–1710)
Authors: Saint-Cast Benoît
Published: July 2024

Bankruptcy was a key institution in the development of markets in Europe. However, the territoriality of jurisdictions and legal systems made international insolvencies difficult to manage. In the middle of the seventeenth century, cities such as Lyon developed networks of cooperation by granting foreign merchants equal rights to local creditors on a reciprocal basis. However, courts were reluctant to give foreign authorities control over assets and creditors on their territory. The article examines how the Lyon commercial court changed its policy towards international insolvencies during the second half of the seventeenth century. Whereas equal treatment of foreign creditors was conditioned on the recognition of an extraterritorial jurisdiction in the medieval fairs system, it now depended on the reciprocity of the legal status granted to merchants abroad. This system of cooperation between equally sovereign courts prefigured in many ways the current situation of private international law in bankruptcy matters.
Argentina’s Commitment to International Criminal Justice to Address the Crimes of the Last Dictatorship (1976–1983)
Authors: Vegh Weis Valeria , Rey Sebastian
Published: July 2024

This article will explain how Argentina developed a strong commitment to international criminal justice to address the crimes of the last dictatorship (1976–1983) that transcended the local dimension and shaped the field globally. In particular, the article will focus on three specific dimensions: the disputes surrounding the concept of ‘dirty war’ in relation to the crimes committed in the 1970s and how its legal conceptualisation has evolved over time; how domestic courts have applied international and domestic criminal law to judge these crimes and how this has changed over time; and, finally, what was the role of human rights organisations in fostering the accountability process.
The Contribution of the European Court of Human Rights to the Construction of a Corruption-Free Society
Authors: Oriolo Anna
Published: July 2024

Corruption is a serious threat to the stability and security of societies, undermining institutions and democratic values, ethical principles, and justice, as well as sustainable development and the rule of law. It manifests itself in many ways and in a multitude of contexts, affecting almost all human rights, including economic and social rights (i.e., the right to work, the right to food, the right to housing, the right to health, the right to education, the right to public services, the right to development), as well as civil and political rights (i.e., the right to equality and non-discrimination, the right to political participation, the right to an effective remedy and to a fair trial). In this perspective, starting from an examination of the direct and negative impact of corruption on the enjoyment of human rights (Section 1), the analysis that follows focuses on the obligations of States to respect, promote, and above all, protect human rights (i.e., take all necessary measures to ensure their full enjoyment) (Section 2), traces the ECtHR’s most incisive pronouncements on violations of individual guarantees in the context of corruption (Section 3), and highlights the crucial role of the Court’s case law in defining more effective, preventive, and punitive measures against corruption (Section 4).
Healing the Incurable? Pentecostal Prayer Camps and Healing of Chronic Illnesses in Ghana
Authors: Benyah Francis Ethelbert Kwabena
Published: July 2024

Healing is one of the distinctive features of the Pentecostal movement. In Pentecostal missiology healing is fundamental and is geared towards the transformation of the human person and society. Healing thus encompasses both physical and spiritual ailments. It also concerns the healing of unjust structures of society – inequality, corruption, bad governance, and so on. In this article I examine some of the plausible factors that make persons living with chronic illnesses go to prayer camps in search of solutions for their illnesses. The article highlights how prayer camps in Ghana help those living with chronic illnesses negotiate their sense of self and identity in the midst of persistent illness. It argues that in a situation where healthcare systems cannot provide a cure for an illness, people identify with and rely on religious institutions and their resources such as those the prayer camps produce for support, meaning, and enhancement.
Missional Masculinities in Pentecostalism in Africa
Authors: Kaunda Chammah J.
Published: July 2024

The article argues for missional masculinities from an incarnational framework as the foundation for imitatio Christi among Pentecostal men in Africa. It suggests that since masculinities are defined by societal ideals that men are expected to embody, Pentecostal men should reclaim the divine vision of the new ‘manity’ in Christ. Here, Christ serves not only as the epitome of new humanity but also as the exemplar, setting the standard and modeling what it means to be human. Jesus is the primordial model, the definition, the determination, the illustration, and most importantly, the beginning and the end of what it means to be human. Therefore, missional masculinities, modeled after Christ, are primed to exhibit kenotic, relational, agapeic, redemptive characteristics, and are everyday prophetic performances of abundant life for humanity and creation.
A Sonic Vaccine for a White-Collar Disease
Authors: Lorea Carola
Published: July 2024

Members of the Matua religion, a displaced Dalit community from Bengal, believe that the coronavirus can affect only the upper-caste/class layers of society, those who sit in air-conditioned offices and live in the big cities. Matua devotees, on the other hand, are predominantly part of an agriculturist community inhabiting multiple fringes: the borderlands of India and Bangladesh, the peripheries of unorthodox Vaishnavism, and the social margins of untouchability. Conducting remote ethnography with Matua participants based in West Bengal, Bangladesh, and the Andamans, one comes across insistent narratives of immunity and recurrent interpretations of the pandemic that fit into the onto-cosmology and sociocultural imagination of the Matua religious movement. I discuss these as dissident tales of immunity that describe COVID-19 as an urban-based white-collar disease. Matua practitioners successfully prevent it through a sonic vaccine – the practice of kīrtan – and a kind of power (śakti) accumulated through physical agricultural labor.
International Criminal Law and the Environment: A Few Reflections
Authors: Martini Pauline
Published: July 2024

The article concludes the Special Issue by exploring the role that international criminal law (ICL) could play in the protection of the environment in light of the three core issues covered in the Special Issue: the right to a healthy environment, climate change litigation and Indigenous peoples’ Earth-Centric vision. First, the paper argues that fora applying ICL, including the International Criminal Court, could offer legal avenues to prosecute serious violations of the right to a healthy environment. Second, it alleges that whilst cases involving conducts leading to environmental degradation and destruction could be brought under ICL, ICL could not address the broader impact of such conducts, including on climate change. Third, it discusses the extent to which ICL could incorporate Indigenous peoples’ Earth-centric approach to enhance the protection of the environment.
What Is Historical Anti-realism and How to Define It?
Authors: Mitrović Branko
Published: July 2024

Authors who advocate historical anti-realism have often insisted that they do not claim that no past events happened or that the past did not happen. In this paper, I show that in spite of such protestations, the core arguments presented by Leon Goldstein, Paul Roth, Frank Ankersmit, and Jouni-Matti Kuukkanen preclude the possibility that the past or past events happened.
The Past in Question: History as Past and Present Problem-Spaces
Authors: Retz Tyson
Published: July 2024

This article underscores the role that questions play in the production of historical knowledge. It stresses two points: (1) the questions arising from the demands of the present are the means by which historians elicit evidence from sources; (2) the questions that arose from the demands of the past are the ‘real past’ in which agents acted in search of answers. Further, by examining David Scott’s application of R.G. Collingwood’s logic of question and answer, the article points to the socio-political dangers of realist aspirations to offer definitive accounts of the past. The example indicates that the political present has much to gain from a critical historical practice attuned to the demands of past and present problem-spaces alike.
Realism, Postmodernism and/as Metanarrative
Authors: O’Sullivan Luke
Published: July 2024

The question of how realism and metanarratives are related in the philosophy of history does not seem to have been widely discussed. Whereas there are distinct philosophical and political senses of ‘realism’, contrasting with ‘idealism’ and ‘utopianism’ respectively, ‘metanarrative’ has a singular meaning based on Jean-François Lyotard’s sceptical definition of postmodernism as “incredulity towards metanarratives”. Lyotard defined metanarratives as philosophies of history that serve some legitimatory function, but claimed that their importance was waning. From this point of view, postmodernism can be described as a species of philosophical ‘realism’. But the appearance of Francis Fukuyama’s ‘end of history’ thesis, which explicitly presented itself as a neo-Hegelian critique of political realism, suggested that Lyotard had underestimated the enduring power of metanarrative insofar as it served the interests of the American liberal-democratic capitalist order. For Jacques Derrida, Fukuyama’s work thus underlined the importance of breaking with what he called ‘onto-theological’ visions of history, although Derrida himself could be seen as authoring a metanarrative in the service of European social democracy. But if so, Derrida’s approach to metanarratives was very different in kind to contemporary religious and nationalistic versions. One way to resolve the difficulty is to make a distinction between modern ‘utopian’ and postmodern ‘realist’ versions of metanarratives.