bluuebunny/crossref_metadata_2025 huggingface dataset:
Développement du sentiment et du pouvoir d’agir : un exemple chez des médecins du travail
Authors: Poussin Nadine , Miossec Yvon
Published: April 2015

L’objectif de cet article, à partir d’une intervention en clinique de l’activité auprès de médecins du travail, est de prendre pour objet d’analyse le lien entre la modification de sentiments et le développement du pouvoir d’agir. Nous partons du cas d’un médecin du travail qui a vu ses sentiments, initialement d’inefficacité et d’inutilité, transformés lors de l’intervention. Au cours de celle-ci, elle a été affectée, décontenancée mais cette déstabilisation a été productive puisqu’elle lui a permis, avec ses collègues, de prendre comme objet de discussion les buts poursuivis dans l’action et ainsi de revenir sur les rapports entre ces buts et les motifs de l’activité. Nous donnons à voir plus précisément une séquence d’un dialogue analysée du point de vue des émotions et des échanges d’arguments. Nous concluons que l’affect qui a provoqué l’embarras a ouvert la voie à une nouvelle manière de voir, d’imaginer et de faire. Cela nous permettra : 1) de distinguer affect, émotion et sentiment ; 2) de poser deux conditions à la transformation des sentiments : l’éprouvé d’un affect et l’enrichissement des significations ; 3) d’attester du lien entre transformation du sentiment et développement du pouvoir d’agir.
The Wars of Love’s Labour’s Lost: Performance and Interpretation
Authors: Carroll William C.
Published: April 2015

This paper investigates the trope of war in relation to the critical and performance history of Love’s Labour’s Lost. The “civil war of wits” has long been recognized as central to the play’s linguistic texture, as has the “war against your own affections” that Navarre urges on his fellow academe-lovers. In addition to these linguistic and psychological threads, the play’s disputed debt between France and Navarre concerns the “wars” waged by Navarre’s father, while the four lords’ names point toward historical actors in the French wars of religion from the 1570s into the 1590s. Beyond these well-cited links, however, the play has an unusual history of being performed in actual war-time, or staged in a war-setting, as in Thomas Mann’s Doctor Faustus, the Branagh film, and productions directed by Robin Phillips, Trevor Nunn and Corinne Jaber, among others. Publicity for the current RSC production describes the setting as just before the First World War, “conjuring up the carefree elegance of a pre-war Edwardian summer.” This paper explores why the play has so frequently been associated with war, and particularly the Edwardian period.
An Unrehearsed Cue Script Perspective on Love’s Labour’s Lost
Authors: Kirtland Andy
Published: April 2015

Based on how Shakespeare’s actors would approach the text, through cue scripts, the Unrehearsed Cue Script Technique is a key to unlock the playwright’s directions written into the text. By looking at some excerpts from Berowne’s cue script we will see how Shakespeare was able to craft plays in such a way that his actors would be able to perform them with little to no group rehearsal.
“I smell false Latin, dunghill for unguem”: Odours and Aromas in Love’s Labour’s Lost
Authors: Sukič Christine
Published: April 2015

The “smell” of Love’s Labour’s Lost could be assessed through its original staging and the context of early modern playhouses, but its olfactory content is mainly metaphorical. The pedants of the play try to impose the sweet smell of knowledge as a social marker that they oppose to the stench of ignorance characterising the lower social classes. The play is also studded with fragrant metaphors that can be traced back to the Petrarchan tradition. However, in both cases, the smells undergo a process of reversibility and the play is often steeped in scatological metaphors as well as images of pestilent air—probably reflecting the context of the plague in early modern London. More importantly, the olfactory metaphors inform us on the aesthetics of the play and give us a clue about the reversibility of language.
C-Type Lectin Receptor MCL Facilitates Mincle Expression and Signaling through Complex Formation
Authors: Miyake Yasunobu , Oh-hora Masatsugu , Yamasaki Sho
Published: April 2015

C-type lectin receptors expressed in APCs are recently defined pattern recognition receptors that play a crucial role in immune responses against pathogen-associated molecular patterns. Among pathogen-associated molecular patterns, cord factor (trehalose-6,6′-dimycolate [TDM]) is the most potent immunostimulatory component of the mycobacterial cell wall. Two C-type lectin receptors, macrophage-inducible C-type lectin (Mincle) and macrophage C-type lectin (MCL), are required for immune responses against TDM. Previous studies indicate that MCL is required for TDM-induced Mincle expression. However, the mechanism by which MCL induces Mincle expression has not been fully understood. In this study, we demonstrate that MCL interacts with Mincle to promote its surface expression. After LPS or zymosan stimulation, MCL-deficient bone marrow–derived dendritic cells (BMDCs) had a lower level of Mincle protein expression, although mRNA expression was comparable with wild-type BMDCs. Meanwhile, BMDCs from MCL transgenic mice showed an enhanced level of Mincle expression on the cell surface. MCL was associated with Mincle through the stalk region and this region was necessary and sufficient for the enhancement of Mincle expression. This interaction appeared to be mediated by the hydrophobic repeat of MCL, as substitution of four hydrophobic residues within the stalk region with serine (MCL4S) abolished the function to enhance the surface expression of Mincle. MCL4S mutant failed to restore the defective TDM responses in MCL-deficient BMDCs. These results suggest that MCL positively regulates Mincle expression through protein–protein interaction via its stalk region, thereby magnifying Mincle-mediated signaling.
Tissue-Specific Regulation of p38α-Mediated Inflammation in Con A–Induced Acute Liver Damage
Authors: Kang Young Jun , Bang Bo-Ram , Otsuka Motoyuki , Otsu Kinya
Published: April 2015

Because p38α plays a critical role in inflammation, it has been an attractive target for the development of anti-inflammation therapeutics. However, p38α inhibitors showed side effects, including severe liver toxicity, that often prevailed over the benefits in clinical studies, and the mechanism of toxicity is not clear. In this study, we demonstrate that p38α regulates the inflammatory responses in acute liver inflammation in a tissue-specific manner, and liver toxicity by p38α inhibitors may be a result of the inhibition of protective activity of p38α in the liver. Genetic ablation of p38α in T and NKT cells protected mice from liver injury in Con A–induced liver inflammation, whereas liver-specific deletion of p38α aggravated liver pathology. We found that p38α deficiency in the liver increased the expression of chemokines to recruit more inflammatory cells, indicating that p38α in the liver plays a protective anti-inflammatory role during acute liver inflammation. Therefore, our results suggest that p38α regulates the inflammatory responses in a tissue-specific manner, and that the tissue-specific p38α targeting strategies can be used for the development of an effective anti-inflammation treatment with an improved side-effect profile.
Environmental Conditions for Akaganeite Formation in Marine Atmosphere Mild Steel Corrosion Products and Its Characterization
Authors: Morcillo M. , González-Calbet J.M. , Jiménez J.A. , Díaz I. , Alcántara J. , Chico B. , Mazarío-Fernández A. , Gómez-Herrero A. , Llorente I. , de la Fuente D.
Published: April 2015

The corrosion of mild steel in chloride-rich atmospheres is a highly topical issue. The formation of the oxyhydroxide akaganeite (β-FeOOH) in this type of atmosphere leads to a notable acceleration of the steel corrosion process. The scientific literature contains many references to outdoor marine atmospheric tests, but so far has failed to clarify two basic matters in relation to akaganeite: the environmental conditions necessary for its formation, and its morphological characterization. Research has been performed at three atmospheric corrosion stations located at Cabo Vilano wind farm (Camariñas, Spain) at different distances from the shoreline (332, 590, and 2,400 m), with chloride deposition rates of 390, 74, and 29 mg/m2/day, respectively, with the exposure of mild steel specimens for 1 year. This paper reports the environmental conditions that generally led to the formation of akaganeite: an annual average relative humidity of around 80% or higher, and simultaneously, an annual average chloride deposition rate of approximately 60 mg/m2/day or higher. Rigorous characterization of akaganeite was performed by x-ray diffraction, scanning electron microscopy/energy dispersive spectroscopy, and transmission electron microscopy/selected area electron diffraction.
Chinese Collection 457: the Call for Global History
Authors: Yangwen Zheng
Published: April 2015

With the help of the Jesuits, the Qianlong emperor (often said to be Chinas Sun
King in the long eighteenth century) built European palaces in the Garden of
Perfect Brightness and commissioned a set of twenty images engraved on copper in
Paris. The Second Anglo-Chinese Opium War in 1860 not only saw the destruction
of the Garden, but also of the images, of which there are only a few left in the
world. The John Rylands set contains a coloured image which raises even more
questions about the construction of the palaces and the after-life of the
images. How did it travel from Paris to Bejing, and from Belgium to the John
Rylands Library? This article probes the fascinating history of this image. It
highlights the importance of Europeans in the making of Chinese history and
calls for studies of China in Europe.
A Series of Fifty-four Clever Drawings on Vellum: Monstrous Births in Italian ms 63
Authors: Warr Cordelia
Published: April 2015

Italian ms 63, now in the John Rylands Library, contains fifty-four images of
monstrous births, both human and animal. The manuscript was probably completed
in the mid-eighteenth century and was owned by Edward Davenport (1778–1847) of
Capesthorne Hall and later by the Manchester-based physician David Lloyd Roberts
(1835–1920). This article explores the possible sources for some of the images,
which range from descriptions or illustrations in well-known publications on
monsters, to popular pamphlets, to drawings and paintings. An analysis of the
choice of subject matter and the ways in which the source material has been used
places the manuscript within eighteenth-century collecting practices and
emphasises the multivalency of the monstrous.
Lancashire Hodge-Podge: Reading the John Rylands Library through the Concept of Hybridity
Authors: Hodgson John
Published: April 2015

Postcolonial theory has yielded productive methodologies with which to examine an
institution such as the John Rylands Library. This paper reinterprets aspects of
the Library‘s history, especially its collecting practices, using Bhabha‘s
concept of hybridity. The Library‘s founder, Enriqueta Rylands, embodied
hybridity and colonial talking back in her remarkable trajectory from a Catholic
upbringing in Cuba, via her conversion to Nonconformity and her marriage to
Manchester‘s most successful cotton manufacturer, to her usurpation of the
cultural hegemony in purchasing spectacular aristocratic collections for her
foundation. Hybridity was embedded in many other aspects of the Library‘s
development: it was established as a public library with a board of governors
but its collections were largely shaped by Enriqueta‘s tastes and interests; it
was independent until 1972, while maintaining very close links to the University
of Manchester; it has always fulfilled a dual remit of addressing the research
needs of scholars and attracting wider audiences; and it is simultaneously a
library of printed books and manuscripts, an archive repository, and a gallery
of visual materials.
Fitorremediación de un residuo de mina asistida con enmiendas y bacterias promotoras de crecimiento
Authors: Stefani Perea-Vélez Yazmín , Rogelio Carrillo-González , Amílcar Solís-Domínguez Fernando , del Carmen A. González-Chávez Ma.
Published: April 2015

El objetivo del presente trabajo fue evaluar estiércol ovino fresco, CaCO3, K2HPO4 y vermicompost para estabilizar elementos potencialmente tóxicos (EPTs) en un residuo de mina, y el efecto de bacterias promotoras del crecimiento vegetal (BPCV) en R. communis. Las enmiendas mejoraron las propiedades físicas y químicas del residuo. En adición, las concentraciones de Pb y Zn extractables con DTPA-TEA-CaCl2 se redujeron 22% y 41%, respectivamente. La biomasa aérea y área foliar de Ricinus communis se triplicó, y la altura se duplicó por efecto de las enmiendas y éstas en conjunto con la inoculación de BPCV con respecto al tratamiento testigo. No obstante, las enmiendas tuvieron mayor influencia sobre el crecimiento de R. communis que la inoculación con BPCV. Las concentraciones de Pb y Cd en la parte aérea fueron mayores a los umbrales de fitotoxicidad en todos los tratamientos. Sin embargo, los factores de bioacumulación de Cd mostraron que las BPCV disminuyen significativamente la acumulación de este elemento en tejido aéreo en comparación con el tratamiento testigo y las enmiendas. No se observaron síntomas visibles de toxicidad (necrosis, clorosis, marchitez o malformaciones) en las plantas de los tratamientos con enmienda e inoculación de BPCV. Las concentraciones de malondialdehído y H2O2 fueron significativamente menores en comparación con las plantas del tratamiento testigo. Las plantas que crecieron en el residuo de mina presentaron baja biomasa y la concentración de Zn en el follaje fue 1.5 veces mayor a los umbrales fitotóxicos. El análisis de correlación linear sugiere que la alta concentración de Zn fue el principal factor en disminuir la tasa de fotosíntesis, biomasa aérea y concentración de clorofila en las plantas testigo. Así mismo, este elemento estimuló la generación de especies reactivas del oxígeno como el H2O2. Finalmente, después de establecer R. communis en el residuo de mina la concentración de Pb extractable con DTPA disminuyo 50% aproximadamente en todos los tratamientos, aparentemente la planta ayuda a estabilizarlo.
Revealing important nocturnal and day‐to‐day variations in fire smoke emissions through a multiplatform inversion
Authors: Saide Pablo E. , Peterson David A. , da Silva Arlindo , Anderson Bruce , Ziemba Luke D. , Diskin Glenn , Sachse Glen , Hair Johnathan , Butler Carolyn , Fenn Marta , Jimenez Jose L. , Campuzano‐Jost Pedro , Perring Anne E. , Schwarz Joshua P. , Markovic Milos Z. , Russell Phil , Redemann Jens , Shinozuka Yohei , Streets David G. , Yan Fang , Dibb Jack , Yokelson Robert , Toon O. Brian , Hyer Edward , Carmichael Gregory R.
Published: April 2015

We couple airborne, ground‐based, and satellite observations; conduct regional simulations; and develop and apply an inversion technique to constrain hourly smoke emissions from the Rim Fire, the third largest observed in California, USA. Emissions constrained with multiplatform data show notable nocturnal enhancements (sometimes over a factor of 20), correlate better with daily burned area data, and are a factor of 2–4 higher than a priori estimates, highlighting the need for improved characterization of diurnal profiles and day‐to‐day variability when modeling extreme fires. Constraining only with satellite data results in smaller enhancements mainly due to missing retrievals near the emissions source, suggesting that top‐down emission estimates for these events could be underestimated and a multiplatform approach is required to resolve them. Predictions driven by emissions constrained with multiplatform data present significant variations in downwind air quality and in aerosol feedback on meteorology, emphasizing the need for improved emissions estimates during exceptional events.
Anharmonic oscillatory flow braking in the Earth's magnetotail
Authors: Panov E. V. , Wolf R. A. , Kubyshkina M. V. , Nakamura R. , Baumjohann W.
Published: April 2015

Plasma sheet bursty bulk flows often oscillate around their equilibrium position at about 10 RE downtail. The radial magnetic field, pressure, and flux tube volume profiles usually behave differently earthward and tailward of this position. Using data from five Time History of Events and Macroscale Interactions during Substorms (THEMIS) probes, we reconstruct these profiles with the help of an empirical model and apply thin filament theory to show that the oscillatory flow braking can occur in an asymmetric potential. Thus, the thin filament oscillations appear to be anharmonic, with a power spectrum exhibiting peaks at both the fundamental frequency and the first harmonic. Such anharmonic oscillatory braking can explain the presence of the first harmonic in Pi2 pulsations (frequency doubling), which are simultaneously observed by magnetometers on the ground near the conjugate THEMIS footprints.
Control of spatially distributed processes with unknown transport‐reaction parameters via two layer system adaptations
Authors: Babaei Pourkargar Davood , Armaou Antonios
Published: April 2015

The control problem of dissipative distributed parameter systems described by semilinear parabolic partial differential equations with unknown parameters and its application to transport‐reaction chemical processes is considered. The infinite dimensional modal representation of such systems can be partitioned into finite dimensional slow and infinite dimensional fast and stable subsystems. A combination of a model order reduction approach and a Lyapunov‐based adaptive control technique is used to address the control issues in the presence of unknown parameters of the system. Galerkin's method is used to reduce the infinite dimensional description of the system; we apply adaptive proper orthogonal decomposition (APOD) to initiate and recursively revise the set of empirical basis functions needed in Galerkin's method to construct switching reduced order models. The effectiveness of the proposed APOD‐based adaptive control approach is successfully illustrated on temperature regulation in a catalytic chemical reactor in the presence of unknown transport and reaction parameters. © 2015 American Institute of Chemical Engineers AIChE J, 61: 2497–2507, 2015
Neurocognitive profile of a young adolescent with DK phocomelia/von Voss phocomelia/von Voss Cherstvoy syndrome
Authors: Antonini Tanya N. , Van Horn Kerne Valerie , Axelrad Marni E. , Karaviti Lefkothea P. , Schwartz David D.
Published: April 2015

DK phocomelia/von Voss Cherstvoy syndrome is a rare condition characterized by upper limb and urogenital abnormalities and various brain anomalies. Previously reported cases have noted significant developmental delays, although no formal testing of cognitive abilities has been reported. In this paper we describe results from a comprehensive neuropsychological evaluation of a 12‐year‐old male with DK phocomelia syndrome. Test findings indicated mild impairment in intellectual functioning, with more significant impairment in adaptive skills and academic achievement. The neuropsychological profile converged with neurological findings, showing a distinct pattern of strengths and weaknesses that suggests functional compromise of posterior brain regions with relatively well‐preserved functioning of more anterior regions. Specifically, impairments were evident in perceptual reasoning, visual perception, and visuomotor integration, whereas normal or near normal functioning was evident in memory, receptive language, social cognition, attention, and most aspects of executive functioning. To our knowledge this is the first report to describe the neurocognitive profile of an individual with DK phocomelia syndrome. © 2015 Wiley Periodicals, Inc.
New recessive truncating mutation in LTBP3 in a family with oligodontia, short stature, and mitral valve prolapse
Authors: Dugan Sarah L. , Temme Renee T. , Olson Rebecca A. , Mikhailov Anna , Law Rosalind , Mahmood Huda , Noor Abdul , Vincent John B.
Published: April 2015

Latent TGFB‐binding protein 3 (LTBP3) is known to increase bio‐availability of TGFB. A homozygous mutation in this gene has previously been associated with oligodontia and short stature in a single family. We report on two sisters with homozygous truncating mutations in LTBP3. In addition to oligodontia and short stature, both sisters have mitral valve prolapse, suggesting a link between truncating LTBP3 mutations and mitral valve disease mediated through the TGFB pathway. © 2015 Wiley Periodicals, Inc.
Resolution of refractory hypotension and anuria in a premature newborn with loss‐of‐function of ACE
Authors: Richer Julie , Daoud Hussein , Geier Pavel , Jarinova Olga , Carson Nancy , Feberova Jana , Nadya Ben Fadel , Unrau Jennifer , Bareke Eric , Khatchadourian Karine , Bulman Dennis E , Majewski Jacek , Boycott Kym M , Dyment David A
Published: April 2015

We present the investigation and management of a premature, hypotensive neonate born after a pregnancy complicated by anhydramnios to highlight the impact of early and informed management for rare kidney disease. Vasopressin was used to successfully treat refractory hypotension and anuria in the neonate born at 27 weeks of gestation. Next generation sequencing of a targeted panel of genes was then performed in the neonate and parents. Subsequently, two compound heterozygous deletions leading to frameshift mutations were identified in the angiotensin 1‐converting enzyme gene ACE; exon 5:c.820_821delAG (p.Arg274Glyfs*117) and exon24: c.3521delG (p.Gly1174Alafs*12), consistent with a diagnosis of renal tubular dysgenesis. In light of the molecular diagnosis, identification, and treatment of associated low aldosterone level resulted in further improvement in renal function and only mild residual chronic renal failure is present at 14 months of age. Truncating alterations in ACE most often result in fetal demise during gestation or in the first days of life and typically as a result of the Potter sequence. The premature delivery, and serendipitous early treatment with vasopressin, and then later fludrocortisone, resulted in an optimal outcome in an otherwise lethal condition. © 2015 Wiley Periodicals, Inc.
Clinical and molecular characterization of an infant with a tandem duplication and deletion of 19p13
Authors: Tan Ratna N. G. B. , Witlox Ruben S. G. M. , Hilhorst‐Hofstee Yvonne , Peeters‐Scholte Cacha M. P. C. D. , den Hollander Nicolette S. , Ruivenkamp Claudia A. L. , Hoffer Mariëtte J.V. , Hansson Kerstin B. , van Roosmalen Mark J. , Kloosterman Wigard P. , Santen Gijs W. E.
Published: April 2015

Copy number variations (CNVs) on the short arm of chromosome 19 are relatively rare. We present a patient with a tandem de novo 3.9 Mb duplication of 19p13.12p13.2 and an adjacent 288 kb deletion of 19p13.12. The CNVs were detected by genome wide SNP‐array and confirmed by fluorescence in situ hybridization. Mate‐pair sequencing revealed two breakpoint junctions leading to a germline tandem inverted duplication and an adjacent deletion. The patient had a major congenital heart defect and refractory edema leading to metabolic and endocrinological disturbances. Further complications occurred due to refractory chylothorax, severe inflammatory response syndrome, and repeating sepsis. After 2 months, the child died due to intractable respiratory failure. The phenotype of this patient was compared with reported patients with overlapping deletions or duplications. We conclude that the congenital heart defect, respiratory insufficiency, and abnormal neurologic examination are most likely due the contiguous gene deletion/duplication. © 2015 Wiley Periodicals, Inc.
Cayo Santiago—A scientific treasure
Authors: Southwick Charles H.
Published: April 2015

This article briefly reviews the contributions of Clarence R. Carpenter in establishing the free‐ranging colony of rhesus monkeys on Cayo Santiago, the Caribbean Primate Research Center and his legacy in primatology. Am. J. Primatol. 78:4–5, 2016. © 2016 Wiley Periodicals, Inc.
Microstructure and properties of carbon fiber sized with pickering emulsion based on graphene oxide sheets and its composite with epoxy resin
Authors: Wang Cuicui , Ge Heyi , Liu Huashi , Guo Shuai
Published: April 2015

The Graphene oxide (GO) sheets were used for preparing the epoxy resin Pickering emulsion. The particle size and the zeta potential of the Pickering emulsion were measured to evaluate its stability. The stable emulsion could be served as the film former of sizing agent for carbon fiber (CF). The effect of the Pickering emulsion stabilized by GO sheets on the properties of CF and the interfacial adhesion property of CF reinforced composite were investigated. Scanning electron microscopy (SEM) images showed that there existed a layer of sizing agent film with GO sheets evenly on the CF surface. Abrasion resistance and stiffness values of CF were tested and the results indicated that the sized CF conformed to the requirement of CF handleability. The interlaminar shear strength (ILSS) test indicated that the interfacial adhesion of the composite could be greatly improved. The fracture surfaces of CF composites were examined by SEM after ILSS tests. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015, 132, 42285.
A multi‐class transit assignment model for estimating transit passenger flows—a case study of Beijing subway network
Authors: Si Bingfeng , Fu Liping , Liu Jianfeng , Shiravi Sajad , Gao Ziyou
Published: April 2015

This paper describes a case study comparing a multi‐class transit assignment model with its single class counterpart for estimating the passenger flows of the Beijing subway network—one of the largest railway transit networks in the world. Multi‐class traffic assignment has been widely considered as a theoretically sound approach to capture the inherent variation in users' route choice behavior. However, few empirical studies have been devoted to showing the effectiveness of this approach in improving the accuracy of the underlying passenger flow estimation process. In this research, a passenger classification scheme is proposed on the basis of a dataset from a large stated preference survey conducted in the City of Beijing, China. Separate generalized cost functions are calibrated for different classes of subway users in Beijing and applied in a multi‐class transit assignment model for estimating passenger flows over a subway network. The case study has shown that the proposed multi‐class approach resulted in significantly improved estimation results with an average estimation error of less than 15% on the transfer flows as compared with 30% for the single class model. Copyright © 2015 John Wiley & Sons, Ltd.
Gender differences in the hepatic elimination and pharmacokinetics of lobeglitazone in rats
Authors: Lee Jong‐Hwa , Son Jun‐Hyeng , Chae Yoon‐Jee , Ahn Sung Hoon , Lee Wooin , Kim Dae‐Duk , Chung Suk‐Jae
Published: April 2015

The pharmacokinetics of lobeglitazone (LB) was studied after intravenous administration at a dose of 1 mg/kg and oral administration at doses of 0.1, 1 and 10 mg/kg in male and female rats. The area under the plasma concentration–time curve from time zero to infinity (AUCinf) after intravenous administration was approximately 7.1 times higher in female rats than in male rats. In addition, the AUCinf in the case of oral administration was at least 4.4 times higher in female rats and appeared to increase in proportion to the dose in both genders. The in vitro half‐lives were 18.8 ± 4.45 min and 60.7 ± 11.2 min, as evidenced by incubating liver microsomes obtained from male and female rats, respectively. As a result, the estimated CLint for LB for male rat liver microsomes (0.0779 ± 0.0233 ml/min/mg protein) was much higher than that for female rat liver microsomes (0.0233 ± 0.0039 ml/min/mg protein, p < 0.05). These observations suggest that there are gender differences in the pharmacokinetics and hepatic metabolism for LB in rats. Copyright © 2015 John Wiley & Sons, Ltd.
President's page
Authors: Hirsh Sandy
Published: April 2015

EDITOR'S SUMMARY

Just after ASIS&T's 2014 Annual Meeting in Seattle, the meeting of the Council of Scientific Society Presidents (CSSP) drew representatives from about 60 organizations, many facing challenges similar to those our Association faces. For ASIS&T president Sandy Hirsh, important takeaways included the realization that many, like ASIS&T, are changing to become more inclusive and that all the CSSP societies benefit from the organization's collective voice to promote public awareness of science. Shared best practices on strategic planning, governance, public and international outreach, diversity and relationships with other organizations will be valuable. Progress within ASIS&T continues on the goals of strategic planning, membership management and advocacy. All are being actively pursued following focus group input and member feedback. The website redesign is nearly complete and serves as a stimulus for broader reassessment and updating efforts.
ASIS&T 2014 award of merit acceptance speech
Authors: Hlava Marge
Published: April 2015

EDITOR'S SUMMARY

Accepting ASIS&T's Award of Merit for 2014, Marge Hlava retraced numerous influences on her information science career, starting with the radio broadcast of the launch of the Russian satellite Sputnik propelling science education. She applied her master's degree in biology to information science and beta testing of early telecommunications systems. In 1978 Hlava started her own company, Access Innovations, and has provided information services for over 2,000 projects over the course of 36 years, despite earthquakes, hurricanes and collapsed roofs. The company develops controlled vocabularies and enriches data with metadata to enhance search and retrieval. Through her years with ASIS&T, Hlava has observed academics, managers and entrepreneurs at Association meetings, each with distinct goals, but notes an increasingly academic focus with real‐life applications more likely to be seen at ASIS&T's IA Summit. She urged more pure research as well as work on practical applications with large‐scale data sets. In closing Hlava thanked the many individuals who supported her along the way.
Large scale simulation of UCG process applying porous medium approach
Authors: Seifi Mojtaba , Chen Zhangxin , Abedi Jalal
Published: April 2015

Underground coal gasification (UCG) has significant advantages and can be categorized as a clean coal technology for producing syngas in situ. However, a comprehensive understanding of the process is lacking, because it takes place deep underground and consists of multiple phenomena. Hence UCG modelling can be employed to investigate different aspects of this process. While small‐scale processes can be mechanistically informative, large‐scale processes may behave quite differently. In this work, detailed 3D simulation modelling of three widely‐applied UCG technologies was conducted for the Ardley coal formation (Alberta, Canada) in order to compare the performance of different technologies at field scale. The results of these comparisons can be helpful for selecting the right technology for a desired UCG pilot test. The results show that in spite of a higher heating value of produced syngas from the P‐CRIP (parallel controlled retracting injection point) method over the L‐CRIP (linear controlled retracting injection point) method, the volumetric rate and sweep efficiency of these methods are comparable. Moreover, we conducted 2D cross‐sectional modelling of the Thulin test as the earliest UCG process at great depth and in tight coal seams to address modelling issues. Several possible approaches, such as geomechanical modelling, are presented to resolve the issues of UCG modelling in tight coal seams. The modelling results are analyzed and compared with the field results. Comparisons show an engineering match for the composition of the produced syngas. Computer Modelling Group's STARS software was used in this study as the porous medium modelling approach.
Phased array coil for implementing parallel MRI in intravascular imaging: A feasibility study
Authors: Omer Hammad , Dickinson Robert J. , Awan Shakil A.
Published: April 2015

The use of intravascular MRI imaging of vessels will provide high quality images for improved diagnosis and treatment. An intravascular MR receive coil provides high SNR because of proximity to the tissue but respiratory and cardiovascular motion may affect the quality of acquired images. Parallel MRI provides a framework to reduce the scan time using multiple coils. This article presents a novel design of a Phased Array MR receive coil for intravascular imaging which can implement Parallel MRI. Cartesian and Radial GRAPPA are used as the main reconstruction algorithms. We demonstrate that Moving Segment Radial GRAPPA provides good image reconstruction with minimum artifacts when data is under‐sampled by a factor of 16. © 2015 Wiley Periodicals, Inc. Concepts Magn Reson Part A 43A: 267–276, 2015.
The dynamic properties of a single‐phase transformer‐based inverter for ups systems
Authors: Rymarski Zbigniew , Bernacki Krzysztof
Published: April 2015

This paper presents two algorithms for the creation of an analytical model of a single‐phase transformer‐based inverter, using either the measurements of the control frequency‐dependent characteristics of the inverter or the initial in‐circuit frequency‐dependent measurements of the transformer. The paper discusses how the parameters of the line transformer influence the dynamic properties of the inverter and, as a consequence, the design of the instantaneous control feedback loop. Line transformers, widely used in industry, have not yet been analysed for use at higher than normal operating frequencies. The basic parameters of the transformer are the nonlinear functions of the primary voltage amplitude and frequency. The paper includes verification of both methods using the breadboard experimental model. In the final step, the inverter control transfer functions are calculated. To show the utility of both models, an exemplary discrete controller for the experimental inverter model has been designed and tested. Copyright © 2015 John Wiley & Sons, Ltd.
Persistent expression of activated notch in the developing hypothalamus affects survival of pituitary progenitors and alters pituitary structure
Authors: Aujla Paven K. , Bogdanovic Vedran , Naratadam George T. , Raetzman Lori T.
Published: April 2015

Background: As the pituitary gland develops, signals from the hypothalamus are necessary for pituitary induction and expansion. Little is known about the control of cues that regulate early signaling between the two structures. Ligands and receptors of the Notch signaling pathway are found in both the hypothalamus and Rathke's pouch. The downstream Notch effector gene Hes1 is required for proper pituitary formation; however, these effects could be due to the action of Hes1 in the hypothalamus, Rathke's pouch, or both. To determine the contribution of hypothalamic Notch signaling to pituitary organogenesis, we used mice with loss and gain of Notch function within the developing hypothalamus. Results: We demonstrate that loss of Notch signaling by conditional deletion of Rbpj in the hypothalamus does not affect expression of Hes1 within the posterior hypothalamus or expression of Hes5. In contrast, expression of activated Notch within the hypothalamus results in ectopic Hes5 expression and increased Hes1 expression, which is sufficient to disrupt pituitary development and postnatal expansion. Conclusions: Taken together, our results indicate that Rbpj‐dependent Notch signaling within the developing hypothalamus is not necessary for pituitary development, but persistent Notch signaling and ectopic Hes5 expression in hypothalamic progenitors affects pituitary induction and expansion. Developmental Dynamics 244:921–934, 2015. © 2015 Wiley Periodicals, Inc.
Genetic structure and historical diversification of catfish Brachyplatystoma platynemum (Siluriformes: Pimelodidae) in the Amazon basin with implications for its conservation
Authors: Ochoa Luz Eneida , Pereira Luiz Henrique G. , Costa‐Silva Guilherme Jose , Roxo Fábio F. , Batista Jacqueline S. , Formiga Kyara , Foresti Fausto , Oliveira Claudio
Published: April 2015

Brachyplatystoma platynemum is a catfish species widely distributed in the Amazon basin. Despite being considered of little commercial interest, the decline in other fish populations has contributed to the increase in the catches of this species. The structure, population genetic variability, and evolutionary process that have driven the diversification of this species are presently unknown. Considering that, in order to better understand the genetic structure of this species, we analyzed individuals from seven locations of the Amazon basin using eight molecular markers: control region and cytochrome b mtDNA sequences, and a set of six nuclear microsatellite loci. The results show high levels of haplotype diversity and point to the occurrence of two structured populations (Amazon River and the Madeira River) with high values for FST. Divergence time estimates based on mtDNA indicated that these populations diverged about 1.0 Mya (0.2–2.5 Mya 95% HPD) using cytochrome b and 1.4 Mya (0.2–2.7 Mya 95% HPD) using control region. During that time, the influence of climate changes and hydrological events such as sea level oscillations and drainage isolation as a result of geological processes in the Pleistocene may have contributed to the current structure of B. platynemum populations, as well as of differences in water chemistry in Madeira River. The strong genetic structure and the time of genetic divergence estimated for the groups may indicate the existence of strong structure populations of B. platynemum in the Amazon basin.
Viral Nanotemplates Armed with Oxygenic Polyoxometalates for Hydrogen Peroxide Detoxification
Authors: Vilona Debora , Sorarù Antonio , Maccato Chiara , Bortolaso Rossella , Trainotti Livio , Valentini Federica , Boaretto Aldrei , Cepek Cinzia , Bonchio Marcella , Carraro Mauro
Published: April 2015

Layer‐by‐layer (LbL) assembly strategies were exploited to decorate wild‐type TMV (tobacco mosaic virus) 1D nanoscaffolds with a totally inorganic, multiredox, tetraruthenate complex belonging to the class of polyoxometalate catalysts. The hybrid capsids give rise to an entangled network of fibrils and ribbon‐like nanoassemblies, whose functional activity was probed towards H2O2 dismutation in neutral water. Combined solid‐state and surface characterization evidence, including Z‐potential, electronic microscopy, thermogravimetry and XPS, delineate a favorable tunability of the nanohybrid material as a function of the added cationic binder.
Prepare your institution for the future with a holistic strategic plan
Authors: Hope Joan
Published: April 2015

When officials at Delaware Valley College started a strategic planning process in 2008, they realized that the institution faced major challenges for meeting enrollment goals.
Provide comprehensive support, boost retention
Authors: Hope Joan
Published: April 2015

When students appear to be struggling, faculty members often suggest tutoring or other academic resources. But what if the student is hungry? What if she is being evicted from her apartment?
Investor Attention and Macroeconomic News Announcements: Evidence from Stock Index Futures
Authors: Chen Jing , Liu Yu‐Jane , Lu Lei , Tang Ya
Published: April 2015

This paper examines the role of investor attention in scheduled macroeconomic announcements, using intraday data from the Chinese Stock Index futures market. Overall, investor attention, proxied by the Baidu Search Index, is significantly higher in the Consumer Price Index (CPI) than in other macroeconomic news. Consistently, only the CPI announcement has a substantial short‐term impact on the price, liquidity, and volatility of the CSI 300 index futures. In addition, the reactions of futures price to CPI announcements are stronger to bad CPI news, more sensitive in high‐inflation periods, and less pronounced on Fridays, consistent with our investor attention behavior findings. © 2015 Wiley Periodicals, Inc. Jrl Fut Mark 36:240–266, 2016
Revisiting the 7‐Phospanorbornene Family: New P‐Alkyl Derivatives
Authors: Kovács Tamara , Fülöp Laura Sz. , Mucsi Zoltán , Karaghiosoff Konstantin , Czugler Mátyás , Keglevich György
Published: April 2015

A series of 1‐alkyl‐3‐methyl‐2,5‐dihydro‐1H‐phosphole oxides were converted to the corresponding phosphole oxides that, by the Diels–Alder reaction with N‐maleimide derivatives or with another unit of phosphole oxide, yielded trapped phosphole oxides or phosphole oxide dimers, respectively, as new 7‐phosphanorbornene 7‐oxides. The stereostructures of three derivatives were evaluated by single crystal X‐ray analysis. The regio‐ and stereospecific dimerization was studied by B3LYP/6‐31G(d,p) quantum chemical calculations, whose results were in accord with syntheses. Novel mechanistic features were explored. The geometrical data obtained by single crystal X‐ray analysis validated the results of quantum chemical calculations, as the deviation was less than 3%.
Persistent benefits of slow titration of paroxetine in a six‐month follow‐up
Authors: Olgiati Paolo , Serretti Alessandro
Published: April 2015

Objective

Paroxetine titration may be difficult in older individuals as they are more sensitive to side effects. The current study extends to 6 months our previously published report in which paroxetine was started at 2.5 mg/day and slowly increased by 2.5 mg on alternate days (slow titration) or rapidly titrated to target dose from 10 mg/day (standard titration) in a naturalistic setting.

Methods

Here, the follow‐up period was extended to 26 weeks. We performed an intent‐to‐treat analysis of 47 subjects from the original sample (major depressive disorder and/or generalized anxiety disorder (GAD); >60 years of age). Missing evaluations were replaced by last observations carried forward. GAD was included as a stratification factor.

Results

Patients in whom paroxetine was slowly up‐titrated were more likely to remit (84.0% vs 54.5%; p = 0.028) and had lower core depression (p = 0.0015) and psychic anxiety levels (p = 0.006) after 26 weeks. Dropout rate was 20% in the slow titration group compared with 77.3% in the standard titration arm (p < 0.001). Patients with GAD accounted for all significant associations. No substantial differences were reported between slow and standard titration groups in the subsample without GAD.

Conclusions

Despite some limitations, these findings suggest that paroxetine treatment should be started at lower doses in older depressed patients and slowly up‐titrated. This strategy would allow to increase antidepressant response and the likelihood of completing treatment cycle in patients with high anxiety levels and GAD comorbidity. Copyright © 2015 John Wiley & Sons, Ltd.
An example of population-level risk assessments for small mammals using individual-based population models
Authors: Schmitt Walter , Auteri Domenica , Bastiansen Finn , Ebeling Markus , Liu Chun , Luttik Robert , Mastitsky Sergey , Nacci Diane , Topping Chris , Wang Magnus
Published: April 2015

This article presents a case study demonstrating the application of 3 individual-based, spatially explicit population models (IBMs, also known as agent-based models) in ecological risk assessments to predict long-term effects of a pesticide to populations of small mammals. The 3 IBMs each used a hypothetical fungicide (FungicideX) in different scenarios: spraying in cereals (common vole, Microtus arvalis), spraying in orchards (field vole, Microtus agrestis), and cereal seed treatment (wood mouse, Apodemus sylvaticus). Each scenario used existing model landscapes, which differed greatly in size and structural complexity. The toxicological profile of FungicideX was defined so that the deterministic long-term first tier risk assessment would result in high risk to small mammals, thus providing the opportunity to use the IBMs for risk assessment refinement (i.e., higher tier risk assessment). Despite differing internal model design and scenarios, results indicated in all 3 cases low population sensitivity unless FungicideX was applied at very high (×10) rates. Recovery from local population impacts was generally fast. Only when patch extinctions occured in simulations of intentionally high acute toxic effects, recovery periods, then determined by recolonization, were of any concern. Conclusions include recommendations for the most important input considerations, including the selection of exposure levels, duration of simulations, statistically robust number of replicates, and endpoints to report. However, further investigation and agreement are needed to develop recommendations for landscape attributes such as size, structure, and crop rotation to define appropriate regulatory risk assessment scenarios. Overall, the application of IBMs provides multiple advantages to higher tier ecological risk assessments for small mammals, including consistent and transparent direct links to specific protection goals, and the consideration of more realistic scenarios. Integr Environ Assess Manag 2016;12:46–57. © 2015 SETAC

Key Points

The applicability of spatially explicit, individual-based population models for small mammal risk assessments for plant protection products was demonstrated. Recommendations were developed for how to use the models for risk assessments and how to evaluate the simulation results. Results of example risk assessments indicated that even with conservative settings the modelling approach will lead to risk refinements, compared to standard risk assessments.
Therapeutic effects of intra‐articular ultra‐purified low endotoxin alginate administration on an experimental canine osteoarthritis model
Authors: Tsukuda Yukinori , Onodera Tomohiro , Ito Masayuki , Izumisawa Yasuharu , Kasahara Yasuhiko , Igarashi Tatsuya , Ohzawa Nobuo , Todoh Masahiro , Tadano Shigeru , Iwasaki Norimasa
Published: April 2015

Objective:This study aimed to elucidate the therapeutic effects of intra‐articular administration of ultra‐purified low endotoxin alginate (UPLE‐alginate) on osteoarthritis (OA) using a canine anterior cruciate ligament transection (ACLT) model.Design:We used 20 beagle dogs. ACLT was performed on the left knee of each dog and a sham operation was performed on the right knee as a control. All animals were randomly divided into the control (saline) and therapeutic (UPLE‐alginate) groups. Animals in the control and therapeutic groups received weekly injections with 0.7 mL normal saline or 0.7 mL 0.5% UPLE‐alginate, respectively, from 0 to 3 weeks after ACLT or sham operation. At 9 weeks after ACLT, the knee joints of all animals were observed using arthroscopy. All animals were euthanized at 14 weeks after ACLT and evaluated using morphologic assessment, histologic assessment, and biomechanical testing.Results:Arthroscopic findings showed intact cartilage surface in both groups. Morphologic findings in the therapeutic group showed milder degeneration compared with those of the control group, but there were no significant differences between groups. Histologic scores of the medial femoral condyle (MFC) and lateral femoral condyle (LFC) were better in the therapeutic group than the control group (MFC:p = 0.009, LFC:p = 0.009). Joint lubrication did not differ significantly between groups.Conclusion:Intra‐articular administration of UPLE‐alginate in the early stage of OA slowed disease progression in canines. UPLE‐alginate may have potential as a therapeutic agent for OA patients and reduce the number of patients who need to undergo total joint arthroplasty. © 2015 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 103A: 3441–3448, 2015.