bluuebunny/crossref_metadata_2025 huggingface dataset:
Supplementary Table 12 from African American Prostate Cancer Displays Quantitatively Distinct Vitamin D Receptor Cistrome-transcriptome Relationships Regulated by BAZ1A
Authors: Siddappa Manjunath , Hussain Shahid , Wani Sajad A. , White Jason , Tang Hancong , Gray Jaimie S. , Jafari Hedieh , Wu Hsu-Chang , Long Mark D. , Elhussin Isra , Karanam Balasubramanyam , Wang Honghe , Morgan Rebecca , Hardiman Gary , Adelani Isaacson B. , Rotimi Solomon O. , Murphy Adam R. , Nonn Larisa , Davis Melissa B. , Kittles Rick A. , Hughes Halbert Chanita , Sucheston-Campbell Lara E. , Yates Clayton , Campbell Moray J.
Published: April 2023

ST_12 ChIP-Seq to RNA-Seq
Supplementary Figure 6 from African American Prostate Cancer Displays Quantitatively Distinct Vitamin D Receptor Cistrome-transcriptome Relationships Regulated by BAZ1A
Authors: Siddappa Manjunath , Hussain Shahid , Wani Sajad A. , White Jason , Tang Hancong , Gray Jaimie S. , Jafari Hedieh , Wu Hsu-Chang , Long Mark D. , Elhussin Isra , Karanam Balasubramanyam , Wang Honghe , Morgan Rebecca , Hardiman Gary , Adelani Isaacson B. , Rotimi Solomon O. , Murphy Adam R. , Nonn Larisa , Davis Melissa B. , Kittles Rick A. , Hughes Halbert Chanita , Sucheston-Campbell Lara E. , Yates Clayton , Campbell Moray J.
Published: April 2023

SF_6 RNA-Seq PCA
Supplementary Figure 5 from African American Prostate Cancer Displays Quantitatively Distinct Vitamin D Receptor Cistrome-transcriptome Relationships Regulated by BAZ1A
Authors: Siddappa Manjunath , Hussain Shahid , Wani Sajad A. , White Jason , Tang Hancong , Gray Jaimie S. , Jafari Hedieh , Wu Hsu-Chang , Long Mark D. , Elhussin Isra , Karanam Balasubramanyam , Wang Honghe , Morgan Rebecca , Hardiman Gary , Adelani Isaacson B. , Rotimi Solomon O. , Murphy Adam R. , Nonn Larisa , Davis Melissa B. , Kittles Rick A. , Hughes Halbert Chanita , Sucheston-Campbell Lara E. , Yates Clayton , Campbell Moray J.
Published: April 2023

SF_5 ChIP-Seq motif
Supplementary Figure 4 from African American Prostate Cancer Displays Quantitatively Distinct Vitamin D Receptor Cistrome-transcriptome Relationships Regulated by BAZ1A
Authors: Siddappa Manjunath , Hussain Shahid , Wani Sajad A. , White Jason , Tang Hancong , Gray Jaimie S. , Jafari Hedieh , Wu Hsu-Chang , Long Mark D. , Elhussin Isra , Karanam Balasubramanyam , Wang Honghe , Morgan Rebecca , Hardiman Gary , Adelani Isaacson B. , Rotimi Solomon O. , Murphy Adam R. , Nonn Larisa , Davis Melissa B. , Kittles Rick A. , Hughes Halbert Chanita , Sucheston-Campbell Lara E. , Yates Clayton , Campbell Moray J.
Published: April 2023

SF_4 VDR cistrome
Supplementary Figure 11 from African American Prostate Cancer Displays Quantitatively Distinct Vitamin D Receptor Cistrome-transcriptome Relationships Regulated by BAZ1A
Authors: Siddappa Manjunath , Hussain Shahid , Wani Sajad A. , White Jason , Tang Hancong , Gray Jaimie S. , Jafari Hedieh , Wu Hsu-Chang , Long Mark D. , Elhussin Isra , Karanam Balasubramanyam , Wang Honghe , Morgan Rebecca , Hardiman Gary , Adelani Isaacson B. , Rotimi Solomon O. , Murphy Adam R. , Nonn Larisa , Davis Melissa B. , Kittles Rick A. , Hughes Halbert Chanita , Sucheston-Campbell Lara E. , Yates Clayton , Campbell Moray J.
Published: April 2023

SF_11 BAZ containing complexes expression
Supplementary Figure 1 from African American Prostate Cancer Displays Quantitatively Distinct Vitamin D Receptor Cistrome-transcriptome Relationships Regulated by BAZ1A
Authors: Siddappa Manjunath , Hussain Shahid , Wani Sajad A. , White Jason , Tang Hancong , Gray Jaimie S. , Jafari Hedieh , Wu Hsu-Chang , Long Mark D. , Elhussin Isra , Karanam Balasubramanyam , Wang Honghe , Morgan Rebecca , Hardiman Gary , Adelani Isaacson B. , Rotimi Solomon O. , Murphy Adam R. , Nonn Larisa , Davis Melissa B. , Kittles Rick A. , Hughes Halbert Chanita , Sucheston-Campbell Lara E. , Yates Clayton , Campbell Moray J.
Published: April 2023

SF_1 workflow
Data from African American Prostate Cancer Displays Quantitatively Distinct Vitamin D Receptor Cistrome-transcriptome Relationships Regulated by BAZ1A
Authors: Siddappa Manjunath , Hussain Shahid , Wani Sajad A. , White Jason , Tang Hancong , Gray Jaimie S. , Jafari Hedieh , Wu Hsu-Chang , Long Mark D. , Elhussin Isra , Karanam Balasubramanyam , Wang Honghe , Morgan Rebecca , Hardiman Gary , Adelani Isaacson B. , Rotimi Solomon O. , Murphy Adam R. , Nonn Larisa , Davis Melissa B. , Kittles Rick A. , Hughes Halbert Chanita , Sucheston-Campbell Lara E. , Yates Clayton , Campbell Moray J.
Published: April 2023

African American (AA) prostate cancer associates with vitamin D3 deficiency, but vitamin D receptor (VDR) genomic actions have not been investigated in this context. We undertook VDR proteogenomic analyses in European American (EA) and AA prostate cell lines and four clinical cohorts. Rapid immunoprecipitation mass spectrometry of endogenous protein (RIME) analyses revealed that nonmalignant AA RC43N prostate cells displayed the greatest dynamic protein content in the VDR complex. Likewise, in AA cells, Assay for Transposase-Accessible Chromatin using sequencing established greater 1α,25(OH)2D3-regulated chromatin accessibility, chromatin immunoprecipitation sequencing revealed significant enhancer-enriched VDR cistrome, and RNA sequencing identified the largest 1α,25(OH)2D3-dependent transcriptome. These VDR functions were significantly corrupted in the isogenic AA RC43T prostate cancer cells, and significantly distinct from EA cell models. We identified reduced expression of the chromatin remodeler, BAZ1A, in three AA prostate cancer cohorts as well as RC43T compared with RC43N. Restored BAZ1A expression significantly increased 1α,25(OH)2D3-regulated VDR-dependent gene expression in RC43T, but not HPr1AR or LNCaP cells. The clinical impact of VDR cistrome-transcriptome relationships were tested in three different clinical prostate cancer cohorts. Strikingly, only in AA patients with prostate cancer, the genes bound by VDR and/or associated with 1α,25(OH)2D3-dependent open chromatin (i) predicted progression from high-grade prostatic intraepithelial neoplasia to prostate cancer; (ii) responded to vitamin D3 supplementation in prostate cancer tumors; (iii) differentially responded to 25(OH)D3 serum levels. Finally, partial correlation analyses established that BAZ1A and components of the VDR complex identified by RIME significantly strengthened the correlation between VDR and target genes in AA prostate cancer only. Therefore, VDR transcriptional control is most potent in AA prostate cells and distorted through a BAZ1A-dependent control of VDR function.
Significance:
Our study identified that genomic ancestry drives the VDR complex composition, genomic distribution, and transcriptional function, and is disrupted by BAZ1A and illustrates a novel driver for AA prostate cancer.
MR-Guided Transurethral Ultrasound Ablation of Prostate Cancer: Initial Experience of Monitoring Tumor Response by Dynamic Apparent Diffusion Coefficient Measurements at 3.0 T
Authors: Meyer Lena , Bohlscheid Andreas , Lemmer Oscar , van de Plas Jeroen , Leboutte Francois , Hadaschik Boris A. , Neisius Andreas , Willinek Winfried A.
Published: April 2023

Introduction: Diffusion-weighted imaging (DWI) as part of multiparametric magnetic resonance imaging (mpMRI) is an important sequence for the detection of prostate cancer (PCa). The objective of this retrospective analysis was to evaluate changes in apparent diffusion coefficient (ADC) measurements in biopsy-proven PCa undergoing TULSA-PRO (MR-guided transurethral ultrasound ablation of the prostate) at 3.0 T after 1, 3, and 6–12 months posttreatment. Methods: Nineteen patients underwent follow-up examinations after 1, 3, and 6–12 months including mpMRI at 3.0 T and urological-clinical examinations with quantitative analysis of ADCs. Results: In PCa, a significant increase of ADC values after 6–12 months was measured after TULSA-PRO treatment by 29.1% (pre-TULSA: 0.79 ± 0.16 × 10−3 mm2/s, 6–12 months: 1.02 ± 0.35 × 10−3 mm2/s), while the corresponding value in the reference tissue decreased by 48.5% (pre-TULSA: 1.20 ± 0.15 × 10−3 mm2/s, 6–12 months: 0.91 ± 0.29 × 10−3 mm2/s). The mean ADC values in the early follow-up groups at 1 and 3 months did not change significantly. Conclusion: DWI with ADC as part of mpMRI can serve as a biomarker to dynamically monitor the follow-up after TULSA after 6–12 months. For early posttreatment progression, it is not suitable due to too many confounding variables.
Soy Gly m 8 sIgE Has Limited Value in the Diagnosis of Soy Allergy in Peanut Ara h 2-Sensitized Adults
Authors: Briceno Daniela , Hendriks Lauren , Breedveld Annelot , Savelkoul Huub F.J. , Jansen Ad , Teodorowicz Malgorzata , Ruinemans-Koerts Janneke
Published: April 2023

Introduction: Recently, specific IgE (sIgE) sensitization against Gly m 8 (soy 2S albumin) has been described as a good diagnostic marker for soy allergy (SA). The aim of this study was to evaluate the diagnostic value of Gly m 8 by determining the sensitization profiles based on the homologues soy allergens Bet v 1, Ara h 1, Ara h 2, and Ara h 3. Methods: Thirty soy-allergic adults were included; sIgE to total soy extract, Gly m 8, Gly m 4, Gly m 5, Gly m 6, Bet v 1, Ara h 1, Ara h 2, and Ara h 3 were determined. Sensitization patterns were analyzed and determined. The clinical relevance of sIgE of Gly m 8 sensitization was measured by assessing its capacity to degranulate basophils in Gly m8-sensitized patients by an indirect basophil activation test (iBAT). Results: Based on the sIgE patterns of sensitization, two groups of SA patients were identified: (i) peanut-associated SA group (all patients were sensitized to one or more of the peanut compounds) and (ii) non-peanut/PR-10-associated SA group (22 patients were sensitized to Gly m 4 and Bet v 1 but not to any of the peanut compounds). A high and significant correlation between total soy extract and Gly m 6 (R2 = 0.97), Gly m 5 (R2 = 0.85), and Gly m 8 (R2 = 0.78) was observed. A nonsignificant correlation was observed between the levels of sIgE of Gly m 8 versus Ara h2. The iBAT results showed that Gly m 8 did not induce basophil degranulation in any of the peanut-associated patients, indicating that the Gly m8 sensitizations were not clinically relevant. Conclusions: Gly m 8 was not a major allergen in the selected soy-allergic population. The iBAT results indicated that Gly m 8 was not able to induce basophil degranulation in sIgE Gly m 8-sensitized soy-allergic patients. Thus, Gly m 8 would have no added value in the diagnosis of SA in the present study population.
COVID-19 Vaccines Are Safely Tolerated in Adolescents with Cutaneous Mastocytosis
Authors: Yuksel Bulut Hande , Ulusoy Severcan Ezgi , Ertugrul Aysegul
Published: April 2023

Introduction: The management of the COVID-19 vaccine in children with mastocytosis is unclear due to a lack of data. In the current study, we aimed to evaluate the adverse reactions following COVID-19 vaccination in adolescents with cutaneous mastocytosis (CM). Methods: This study included 27 paediatric patients who were diagnosed with CM and were followed up in the paediatric allergy department of a tertiary care children’s hospital. Results: The median (IQR) age of the patients at the time of COVID-19 vaccination was 180 (156–203) months. Forty-four per cent of patients were vaccinated with the COVID-19 vaccine. Among all participants, the vaccination rate was found to be higher in older children, those who had been diagnosed with MPCM, and those who had not been infected with COVID-19 (p = 0.019, p = 0.009, p = 0.002, respectively). A total of 23 doses of the COVID-19 vaccine, including two doses of Sinovac/CoronaVac and 21 doses of Pfizer/BioNTech, were administered to 12 paediatric patients with CM. One of the patients had a history of intense itch, erythematous urticarial plaques, and had an exacerbation of existing skin lesions within 24–48 h after both doses of Pfizer/BioNTech vaccination. Conclusion: The COVID-19 vaccination of patients with CM in this series seems to be safe, and the rate of adverse events was comparable to that in the general population. These results found in adolescents with CM are in line with the existing evidence that CM does not preclude vaccination in children.
The effect of ex-add learning techniques on critical thinking skills and pedagogic competence of Islamic education students
Authors: Mahfudz Mahfudz , Sukarno Sukarno
Published: April 2023

This study aimed to determine the effect of explain-analysis-doing-discussion or known as ex-add learning techniques on critical thinking skills and pedagogic competence of Islamic religious education students at State Islamic University (UIN) Sulthan Thaha Saifuddin Jambi and at UIN Raden Fatah Palembang, Indonesia. The approach used quantitative with quasi-experimental techniques. The number seen in this study was 31 students from UIN Sulthan Thaha Saifuddin Jambi. The data were obtained using tests, namely pretest, and posttest. The test instrument was in the form of multiple-choice questions, each consisting of 40 questions. Data analysis was carried out using percentage techniques, N-gain analysis, and a T-test. Based on the data and discussion that has been done, it can be concluded that the ex-add technique in ‘learning methods and strategies’ can increase critical thinking skill (CTS) and pedagogic competence (PC) respectively by 78 .23% in the ‘high’ category and 59.81% in the ‘medium’ category. This is reinforced by the results of the T-test that both variables obtain a value (2-tailed) of 0.0000.05. This means that there is an average difference between the pretest and posttest scores for each variable. In other words, it can be said that the increase in student CTS and PC after participating in learning with the ex-add technique is significant.
Abnormal Mechanics Relate to Myocardial Fibrosis and Ventricular Arrhythmias in Patients With Mitral Valve Prolapse
Authors: Nagata Yasufumi , Bertrand Philippe B. , Baliyan Vinit , Kochav Jonathan , Kagan Ruth D. , Ujka Kristian , Alfraidi Hassan , van Kampen Antonia , Morningstar Jordan E. , Dal-Bianco Jacob P. , Melnitchouk Serguei , Holmvang Godtfred , Borger Michael A. , Moore Reece , Hua Lanqi , Sultana Razia , Calle Pablo Villar , Yum Brian , Guerrero J. Luis , Neilan Tomas G. , Picard Michael H. , Kim Jiwon , Delling Francesca N. , Hung Judy , Norris Russell A. , Weinsaft Jonathan W. , Levine Robert A.
Published: April 2023

Background:

The relation between ventricular arrhythmia and fibrosis in mitral valve prolapse (MVP) is reported, but underlying valve-induced mechanisms remain unknown. We evaluated the association between abnormal MVP-related mechanics and myocardial fibrosis, and their association with arrhythmia.

Methods:

We studied 113 patients with MVP with both echocardiogram and gadolinium cardiac magnetic resonance imaging for myocardial fibrosis. Two-dimensional and speckle-tracking echocardiography evaluated mitral regurgitation, superior leaflet and papillary muscle displacement with associated exaggerated basal myocardial systolic curling, and myocardial longitudinal strain. Follow-up assessed arrhythmic events (nonsustained or sustained ventricular tachycardia or ventricular fibrillation).

Results:

Myocardial fibrosis was observed in 43 patients with MVP, predominantly in the basal-midventricular inferior-lateral wall and papillary muscles. Patients with MVP with fibrosis had greater mitral regurgitation, prolapse, and superior papillary muscle displacement with basal curling and more impaired inferior-posterior basal strain than those without fibrosis (
P
<0.001). An abnormal strain pattern with distinct peaks pre–end-systole and post–end-systole in inferior-lateral wall was frequent in patients with fibrosis (81 versus 26%,
P
<0.001) but absent in patients without MVP with basal inferior-lateral wall fibrosis (n=20). During median follow-up of 1008 days, 36 of 87 patients with MVP with >6-month follow-up developed ventricular arrhythmias associated (univariable) with fibrosis, greater prolapse, mitral annular disjunction, and double-peak strain. In multivariable analysis, double-peak strain showed incremental risk of arrhythmia over fibrosis.

Conclusions:

Basal inferior-posterior myocardial fibrosis in MVP is associated with abnormal MVP-related myocardial mechanics, which are potentially associated with ventricular arrhythmia. These associations suggest pathophysiological links between MVP-related mechanical abnormalities and myocardial fibrosis, which also may relate to ventricular arrhythmia and offer potential imaging markers of increased arrhythmic risk.
Ischemia in Anomalous Aortic Origin of a Right Coronary Artery: Large Pediatric Cohort Medium-Term Outcomes
Authors: Doan Tam T. , Sachdeva Shagun , Bonilla-Ramirez Carlos , Reaves-O’Neal Dana L. , Masand Prakash , Mery Carlos M. , Binsalamah Ziyad , Heinle Jeffrey H. , Molossi Silvana
Published: April 2023

Background:

Anomalous aortic origin of a right coronary artery may cause myocardial ischemia and sudden death in the young. Data on myocardial ischemia or longitudinal outcomes are sparse in pediatric anomalous aortic origin of a right coronary artery population.

Methods:

Patients <21 years with anomalous aortic origin of a right coronary artery were prospectively enrolled. Computerized tomography angiography defined morphology. Exercise stress test and stress perfusion imaging (sPI) were performed if >7 years or younger with concern for ischemia. High-risk features included intramural length, slit-like/hypoplastic ostium, exertional symptoms, or evidence of ischemia.

Results:

A total of 220 patients (60% males) were enrolled December 2012 to April 2020 at a median age 11.4 years (interquartile range, 6.1–14.5), including 168 (76%) with no/nonexertional symptoms (group 1) and 52 (24%) with exertional chest pain/syncope (group 2). Computerized tomography angiography was available in 189/220 (86%), exercise stress test in 164/220 (75%), and sPI in 169/220 (77%). Exercise stress test was positive in 2/164 (1.2%) patients in group 1, both had positive sPI. Inducible ischemia (sPI) was detected in 11/120 (9%) in group 1 and 9/49 (18%) in group 2 (P=0.09). Intramural length was similar in patients with/without ischemia (5 [interquartile range, 4–7] versus 5 [interquartile range, 4–7] mm;P=0.65). Surgery was recommended in 56/220 (26%) patients with high-risk features. In 52 surgical patients (38 unroofing, 14 reimplantation), all subjects were alive and have returned to exercise at last median follow-up of 4.6 (interquartile range, 2.3–6.5) years.

Conclusions:

Anomalous aortic origin of a right coronary artery patients can present with inducible ischemia on sPI despite symptoms or intramural length. Exercise stress test is a poor predictor of ischemia and caution should be given to determine low-risk based solely on this assessment. All patients are alive at medium-term follow-up.
An annotated catalog of the type material of Adephaga and Myxophaga (Coleoptera) deposited in the Florida State Collection of Arthropods in Gainesville, Florida, United States of America
Authors: KELLER OLIVER , SCHNEPP KYLE E. , ASHMAN KRYSTAL L. , TURNBOW ROBERT H. , SKELLEY PAUL E.
Published: April 2023

The Florida State Collection of Arthropods (FSCA) ranks in the top 10 largest Coleoptera collections in the United States of America with in excess of 1.5 million pinned beetles and significant amounts of materials in bulk collections and other unprocessed samples. The suborder Adephaga currently comprises approximately 34,000 species in 10 extant families and the suborder Myxophaga contains approximately 94 species in four extant families. The FSCA owns type material in the adephagan families Carabidae, Dytiscidae, Gyrinidae, Haliplidae, and Noteridae. The myxophagan holdings in the FSCA include type material from the families Hydroscaphidae and Lepiceridae. There were no holdings of type material in the suborder Archostemata at FSCA. This catalogue documents the FSCA type material for 253 species in 80 genera across the two suborders. A total of 3,528 type specimens are reported, including 60 holotypes, 36 allotypes, 3,426 paratypes, and six syntypes.
Flash Drought Intensification due to Enhanced Land–Atmospheric Coupling in India
Authors: Mahto Shanti Shwarup , Mishra Vimal
Published: April 2023

Land–atmospheric feedback influences the occurrence and severity of flash droughts. However, the observed and projected changes in flash droughts and associated land–atmospheric coupling have not been examined over India. Moreover, the causes of the rapid depletion of soil moisture during flash droughts are not well known. We identify major flash droughts and associated soil moisture–vapor pressure deficit (SM–VPD) coupling in India using ERA5 and simulations from global climate models (CMIP6-GCMs). The summer monsoon season (June–September) witnesses more than 60% of the flash drought events and a relatively higher rate of flash drought development. The flash drought frequency has mainly decreased during India’s observed climate (1980–2019), which is projected to decline further in the future warming climate. On the other hand, the flash drought development rate has significantly increased during the observed period, which is projected to enhance further under the warming climate. SM–VPD coupling during the flash drought onset-development phase is considerably higher (threefold to fivefold) than during the normal condition (in the absence of flash drought). The high (low) SM–VPD coupling explains the faster (slower) flash drought development rate in the observed and future warming climate. The strength of SM–VPD coupling has increased in the recent period and is projected to increase further in the future warming climate. The increased SM–VPD coupling can intensify future flash droughts in India, especially during the summer monsoon season, with considerable implications for agriculture, water resources, and ecosystems.

Significance Statement

This study aims to understand better the role of land–atmospheric coupling in explaining flash drought characteristics (frequency and development rate) in India. Strong land–atmospheric (SM–VPD) feedback might influence the regional weather patterns during flash drought, which often negatively impacts humans and the ecosystem. We explain the causes and drivers of increasing (decreasing) flash drought development rate (frequency) in India. The long-term change in SM–VPD coupling drives the frequency of flash drought, whereas an anomalous instantaneous change in coupling controls the flash drought development rate. More intense flash droughts contributed by the increased land–atmospheric coupling are projected in the future. Predicting the SM–VPD coupling metric can facilitate more time for preparedness, resulting in minimizing the flash drought impacts.
Presumptive Diagnosis in Tele-Health Laryngology: A Multi-Center Observational Study
Authors: Montalbaron Michael B. , Achlatis Efstratios , Johnson Aaron M. , Ma Yue , Young VyVy N. , Rosen Clark A. , Amin Milan R. , Kwak Paul E.
Published: April 2023

Objectives:

Early in the COVID-19 pandemic, outpatient visits were adapted for the virtual setting, forcing laryngologists to presume certain diagnoses without the aid of laryngoscopy, solely based on history and the limited physical exam available via video visit. This study aims to examine the accuracy of presumptive diagnoses made via telemedicine, compared to subsequent in-person follow up, where endoscopic examination could confirm or refute suspected diagnoses.

Methods:

A retrospective chart review was conducted of 38 patients evaluated for voice-related issues at NYU Langone Health and the University of California-San Francisco. Presumptive diagnoses at the initial telemedicine encounter were noted, along with diagnostic cues used for clinical reasoning and recommended treatment plans. These presumptive diagnoses were compared to diagnoses and plans established following laryngoscopy at follow-up in-person visits.

Results:

After laryngoscopy at the first in-person visit, 38% of presumptive diagnoses changed, as did 37% of treatment plans. The accuracy varied among conditions. Muscle tension dysphonia and Reinke’s edema were accurately diagnosed without laryngoscopy, but other conditions, including vocal fold paralysis and subglottic stenosis, were not initially suspected, relying on laryngoscopy for diagnosis.

Conclusions:

While some laryngologic conditions may be reasonably identified without in-person examination, laryngoscopy remains central to definitive diagnosis and treatment. Telemedicine can increase access to care, but it may provide more utility as a screening tool, triaging which patients should present more urgently for in-person laryngoscopy.

Level of Evidence:

4
Teachers’ Experiences of Emergency Remote Schooling During the Pandemic: Drivers for Student and Teacher Wellbeing
Authors: Burke Paul F , Schuck Sandy , Kearney Matthew
Published: April 2023

This article discusses findings from a recent survey ( n = 297) of teachers’ views of both their own and their students’ experiences during the 2021 enforced emergency remote schooling period occurring in New South Wales Australia, due to the COVID-19 pandemic. The quantitative analysis reported here explores teachers’ views regarding teaching and learning during this challenging period. It identifies three latent constructs, learning, assessment, and interaction, and then uses structural equation modelling to identify the perceived impact of these constructs on student and teacher wellbeing. The remote schooling period had a significant negative impact for teachers and their students across a range of elements of teaching and learning, as well as wellbeing. Student learning experiences and their peer interactions were found to be strong predictors of students’ wellbeing outcomes. Assessment design and teachers’ feedback to students were significant in predicting levels of teacher wellbeing. Future research directions are also provided.
The Emergence of Dominant Designs in Artificial Intelligence
Authors: Ferràs-Hernández Xavier , Nylund Petra A. , Brem Alexander
Published: April 2023

Artificial intelligence (AI) technologies are engaged in a harsh battle for market dominance. This article examines the emergence of a dominant design in terms of technology, service, and business model innovation. We conduct a theoretical synthesis of the literature on industrial organization, technology management, network economics, operations management, and strategic management—with the implications of each theory related to the dominant-design battle in AI. The findings indicate a dominant design for AI will be based on innovation concerning business models as much as on technology, and that the dominant business model will include AI as a service.
Nonconcurrent Multiple-Baseline and Multiple-Probe Designs in Special Education: A Systematic Review of Current Practice and Future Directions
Authors: Morin Kristi L. , Lindström Esther R. , Kratochwill Thomas R. , Levin Joel R. , Blasko Alyssa , Weir Amanda , Nielsen-Pheiffer Christiana M. , Kelly Samantha , Janunts Davit , Hong Ee Rea
Published: April 2023

Although quality guidelines for single-case intervention research emphasize the importance of concurrent baselines in multiple-baseline and multiple-probe designs, nonconcurrent variations on these designs persist in the research literature. This study describes a systematic review of special education intervention studies ( k = 406) between 1988 and 2020 that report using nonconcurrent multiple-baseline or multiple-probe designs to test interventions for individuals with disabilities ages 21 years and younger. We coded and synthesized study characteristics pertaining to participants, settings, interventions, data reporting, and contextual factors. Findings indicate the prevalence of nonconcurrent designs for intervention studies in a variety of settings addressing social and communication needs of individuals with disabilities. We discuss implications for research and practice and offer suggestions for improving the validity of nonconcurrent designs. A PRISMA-compliant abstract is available at https://osf.io/sdnj5/?view_only=f386b1fe5f14430a8d63fceed293718d .
Socioeconomic Determinants of Food Insecurity in Iran: A Systematic Review
Authors: Narmcheshm Saba , Esmaillzadeh Ahmad , Babashahi Mina , Sharegh Farid Elham , Dorosty Ahmad Reza
Published: April 2023

Food insecurity (FI) is a major global health challenge despite the actions taken to combat it. Social and economic factors can affect food security. This study aimed to systematically review research evidence to investigate socioeconomic determinants of FI in the healthy Iranian population. Three databases and search engines, including PubMed, Scopus, and Web of Science as well as Iranian scientific search engines, including Scientific Information Database (SID) and Magiran were systematically searched in English and Persian to identify relevant articles from 1990 until October 2022. A total of 6624 studies were identified. After screening, 115 cross-sectional and 6 case–control studies were included. We separated the results based on rural, urban, and suburban areas. Socioeconomic factors which were correlated to FI in both urban and rural areas were family head education level, parent’s occupation, family head occupation, occupation diversity, number of working persons in a family, marital status of the family head, family size, number of children, household’s economic status, house area, house ownership, and living facilities. Many socioeconomic determinants affect IF in the urban, rural, and suburban areas; so, policymakers should have comprehensive attention on these factors, specifically to improve food security status and support society’s health.
“Hope and grief woven together”: Consolation in a queer reading of Arundhati Roy’s The Ministry of Utmost Happiness
Authors: Kłaniecki Beniamin
Published: April 2023

This article considers the role of consolation in a biopolitical and queer reading of Arundhati Roy’s The Ministry of Utmost Happiness (2017). As a critique of contemporary Indian politics, Hindu nationalism, casteism, and economic neoliberalism, the novel promises to bring hope to those marginalized and dehumanized in “New India” — the “Unconsoled”. It is argued that Ministry’s liberatory potential is best realized when approached from a combined perspective of biopolitical liminality, that of Agambenian homo sacer and Butlerian precarity, as well as the reformative and reparative practices of queer theory. When viewed through queer readings of failure and non-imperative happiness, the alternative world of Jannat Guest House becomes a queer counterpublic, whereas its inhabitants become agents of subversion, whose mere existence defies the imperative of religious, caste, cisheteronormative and capitalist hegemonies endorsed by the state. The article positively assesses the novel’s ability to bring consolation. However, it indicates that there are also limitations to that and offers suggestions as to how to reaffirm the reformatory potential of the novel.
Powders of rGO-coated polyamide with special electrical properties for SLS 3D printing
Authors: Torkunov Mikhail , Shiyanova Kseniya , Verkhova Elizaveta , Yulovskaya Victoria , Ryvkina Natalia , Melnikov Valery , Gudkov Maksim , Chmutin Igor
Published: April 2023

Developing new polymer composites with special properties for 3D printing is one of the most attractive tasks. In our study, we have developed new polymer powders based on rGO-coated polyamide suitable for Selective Laser Sintering (SLS) printing. The obtained materials were characterized using optical microscopy, UV-Vis spectroscopy, scanning electron microscopy and dielectric spectroscopy. The size distribution of the powder particles, the angle of rest after an avalanche, the compactibility (Hausner ratio), the optical properties (absorption and transmission) of the powder monolayer, and the electrical conductivity of the obtained materials have been studied. It has been shown that the developed powders are suitable for the use in the framework of the SLS method, and can be applied to remove static electricity, as well as in reflective screens for electromagnetic radiation.
Nudging the Ship in the Right Direction: United States Public Diplomacy and Development in 1960s Spain
Authors: Martín García Óscar J.
Published: April 2023

In the early 1960s, Franco's Spain began to experience a rapid process of economic growth, which was encouraged by US diplomacy as it would underpin the stability required by the US defence program in the country. However, American officials felt that such an accelerated economic development should be orderly since chaotic modernization might spark social turmoil that would compromise the US geo-strategic objectives in Spain. The article unravels the US public diplomacy programs to steer Spanish society along with a stable development path based on US-inspired capitalism and alliance with the Western bloc. It examines the cultural, educational, and informational means employed by the US government in a bid to channel the socio-economic upheaval occurring in Spain in a direction that was compatible with US security interests. We also argue that modernization theory provided the ideological and intellectual framework for US persuasion efforts to harness Spain's socio-economic ferment. Nevertheless, the ‘development model’ promoted by the dictatorship generated inequalities and conflicts that fuelled anti-American sentiment among sectors of Spanish society called to play a role in the future post-Franco transition.
The Viceroyalty of General Queipo de Llano in Seville During the Spanish Civil War: A Dialectic of Violence and Destitution
Authors: Serém Rúben Leitão
Published: April 2023

This article reappraises General Queipo de Llano's authoritarian rule in Seville during the Spanish Civil War (1936–9). Queipo's murderous regime has long attracted scholarly attention, but very little research has been devoted to other aspects of his administration. Perhaps one exception to this rule is that several works have attempted to enhance Queipo's reputation, portraying the general not only as a military genius, but also as an economic visionary and architect of a proto-welfare state. Building on the concept of Queipo's ‘kleptocratic state’, the present article not only refutes this myth, but also demonstrates that economic policy was crucial to (and inseparable from) the process of physical repression in Seville. The new regime was thus founded on a brutal dialectic of violence and destitution. Prioritizing the liquidation of their perceived enemies, Spain's military rebels massacred thousands in the city after the coup of July 1936. The economic chaos wrought by the mass-killings soon compelled the insurgents to adopt a series of mitigating measures, but the murderous project was not abandoned. Indeed, as the article demonstrates, even ostensibly humanitarian measures must be regarded as part of a broader punitive, restrictive and ideological rebel ethos.
‘Plausible Enough’: The IRO and the Negotiation of Refugee Status After the Second World War
Authors: Huhn Sebastian
Published: April 2023

National Socialism, the Second World War, Stalinism, the expansion of the Soviet Union, and other political crises in Europe led to millions of people fleeing or being abducted in the 1930s and 1940s. The ‘European refugee problem’ led to the establishment of several international organizations. With the founding of the International Refugee Organization (IRO) in 1946, the concept of refugees changed. For the first time, those that had previously been inevitably labelled refugees – whether as groups or individuals – now had to apply for this status. I argue that refugee status was not simply granted or denied by the IRO, but rather negotiated between IRO officers and applicants, often via a protracted, multistage process. These negotiations were based on the applicants’ portrayal of their own personal history and not (only) an objective history itself. However, the question is not only whether people told the ‘truth’ or not; rather, the applicants’ individual ‘negotiation skills’ and individual perceptions of the IRO officers also played a decisive role. Whilst most current research looks at the actions and strategies of ethnic, religious, national, or social groups, I expand this perspective with a focus on individual negotiations of being recognized as a refugee or Displaced Person by the IRO.
“Wanna get married?”: The taxi driver transportation network at the marriage mill of Elkton, Maryland, 1913–1941
Authors: Epstein Seth
Published: April 2023

This article examines the development of a taxi drivers’ transportation network in the “marriage mill” of Elkton, Maryland between 1913 and 1941. It explores how legal conditions for marriage engendered particular forms of spatial organisation meant to accomplish the intensive production of weddings. Social policy impacted how space was organised and connected, but in ways different than authorities expected. The network drivers sought to maintain took direction from the conditions set by political authorities yet simultaneously threatened those conditions’ corruption in the eyes of many. Local and state authorities’ further attempts at regulation as well as changes in transportation together created a greater need for more durable associations between drivers, clergy, and technologies such as vehicles, trains, and advertising signs that they enlisted in their efforts. The article contends that a full accounting of the social consequences of marriage policies should encompass the networks that those policies facilitated.
Optimization of overhead enclosure monitoring in juvenile male Dunkin Hartley guinea pigs (Cavia porcellus)
Authors: Helbling Joel E , Spittler Alexa P , Sadar Miranda J , Santangelo Kelly S
Published: April 2023

Overhead enclosure monitoring provides objective quantitative mobility measurements for animals undergoing open-field testing. Notably, protocols for testing optimization have been minimally established for the guinea pig. It is unknown whether (a) repeated exposure, (b) time-of-day, or (c) length of testing duration influence outcome parameters. We hypothesized that guinea pigs would display decreased activity following repeated exposure to the open field; heightened activity during the earliest testing period; and that 10 min would be adequate for data collection. The study was conducted in two separate phases to distinguish between enclosure habituation and time-of-day effects, respectively. Two cohorts of male Dunkin Hartley guinea pigs were allowed voluntary movement in an open-field enclosure for 14 min to quantify mobility outcomes, including total distance traveled, total time mobile, average speed while mobile, and total time spent in the shelter. For both phases, testing occurred at four different times of day, and overhead monitoring software was programmed to divide the total testing duration into 2-min bins. Habituation phase results showed time mobile and distance traveled were influenced significantly by repeat exposure, as animals were most active during the first testing event. Time-of-day phase animals spent significantly more time mobile during the earliest testing period. Interestingly, significant differences were observed across 2-min bins for the time-of-day phase but not during the habituation phase. Specifically, progressively decreased ambulatory activity was observed as testing duration increased. Thus, habituation and time-of-day should be accounted for when possible. Finally, a trial period greater than 10 min may not yield additional data.
Refinement of systemic guinea pig deafening in hearing research: Sensorineural hearing loss induced by co-administration of kanamycin and furosemide via the leg veins
Authors: Behrends Wiebke , Ahrens Daniel , Bankstahl Jens P. , Esser Karl-Heinz , Paasche Gerrit , Lenarz Thomas , Scheper Verena
Published: April 2023

Auditory disabilities have a large impact on the human population worldwide. Research into understanding and treating hearing disabilities has increased significantly in recent years. One of the most relevant animal species in this context is the guinea pig, which has to be deafened to study several of the hearing pathologies and develop novel therapies. Applying kanamycin subcutaneously and furosemide intravenously is a long-established method in hearing research, leading to permanent hearing loss without surgical intervention at the ear. The intravenous application of furosemide requires invasive surgery in the cervical area of the animals to expose the jugular vein, since a relatively large volume (1 ml per 500 g body weight) must be injected over a period of about 2.5 min. We have established a gentler alternative by applying the furosemide by puncture of the leg veins. For this, custom-made cannula-needle devices were built to allow the vein puncture and subsequent slow injection of the furosemide. This approach was tested in 11 guinea pigs through the foreleg via the cephalic antebrachial vein and through the hind leg via the saphenous vein. Frequency-specific hearing thresholds were measured before and after the procedure to verify normal hearing and successful deafening, respectively. The novel approach of systemic deafening was successfully implemented in 10 out of 11 animals. The Vena saphena was best suited to the application. Since the animals’ condition, post leg vein application, was better in comparison to animals deafened by exposure of the Vena jugularis, the postulated refinement that reduced animal stress was deemed successful.
Pathologic copulatory lock in a genetically engineered laboratory mouse breeding pair
Authors: Leung Glory , Ricart-Arbona Rodolfo , Monette Sebastien , Lipman Neil S
Published: April 2023

A breeding pair of genetically engineered laboratory mice ( Mus musculus) presented in apparent copulatory lock (coital tie). After anesthetizing the animals, gentle traction was used to separate the pair at which point a vaginal prolapse was detected and the penis was covered with black, firm, dry crusts and noted to have a solid pale, tan, firm cylindrical mass adhering to its glans. The vaginal prolapse was reduced and the female was returned to its cage. The male mouse had a severely distended bladder which could not be expressed and was euthanized. Histopathologic examination of the distal two-thirds of the penis revealed diffuse, acute coagulative necrosis. The mass adhered to the distal penis was a homogenous granular eosinophilic material consistent with a copulatory plug. While copulatory plugs and locks have been described in some rodent species, they have not been reported in laboratory mice. While the cause of the adherence of the plug to the penis could not be determined, we hypothesize that its adherence to both the penis and the vagina led to the lock and subsequently to ischemic necrosis of the distal penis.
The Mediating Role of Tolerance for Psychological Pain in the Relationship Between Different Types of Childhood Traumatic Experiences and Suicidal Ideation
Authors: Passos Bruna , Campos Rui C. , Reixa Cátia , Holden Ronald R.
Published: April 2023

The aim of the present research was to evaluate the mediating effects of facets of the tolerance for psychological pain on the relationship between childhood trauma and suicidal ideation. A sample of 437 community individuals and a sample of 316 college students participated. For the community sample, managing the pain mediated the relationship between childhood trauma, the different types of traumatic experiences and suicidal ideation. In the college sample, managing the pain and enduring the pain mediated the relationship between childhood trauma, the different types of traumatic experiences and suicidal ideation, except for the case of sexual abuse. The present results have potential clinical implications. Mental health professionals should be aware of the long-term consequences of exposure to childhood trauma and need to assess the ability to tolerate psychological pain so as to implement appropriate psychological interventions that help individuals cope with their pain.
Using Aid to Control Migration
Authors: Christensen James , Simon Miranda
Published: April 2023

This article examines the practice of using aid to control migration, which we refer to as ‘inducement aid’. We examine two potential objections to inducement aid, each of which concerns a message that the practice communicates to two corresponding audiences: would-be migrants and other developed states. We suggest that the first objection has intuitive force but is undermined by a powerful reply. This finding seems to bolster the intuitive appeal that inducement aid might exhibit as a non-compulsory and apparently option-enhancing form of migration control. However, we argue that the second objection, which targets inducement aid in its capacity as a form of development assistance, has greater power. Developing the second objection, we argue that inducement aid threatens the establishment and maintenance of important international norms, thereby risking degrading the options of the world’s poorest people and setting back the cause of cosmopolitan morality.
A transport of one’s own: Women in contemporary Mexico City’s public transport through the lens of photojournalism
Authors: Franco Teresa
Published: April 2023

This article proposes the use of photojournalism to understand women’s urban mobility practices in contemporary Mexico City. Throughout the analysis, a variety of issues such as economic violence, time poverty and sexual harassment emerge. In general, the article argues that, by analysing the cultural representations that circulate within different media in a specific social and historical context, particular experiences of urban mobilities are made visible, thereby enriching current urban mobility scholarship. Specifically, the article explores how the analysis of material makes visible the various and distinct encounters that women experience when using public transport in Mexico City. The article makes the case that there is already plenty of scholarship within the humanities and cultural studies that could be integrated into existing research on urban mobility practices, enhancing our understanding of how such practices are distinct in particular locations and time periods, and ultimately helping to achieve a more complex and nuanced understanding of them.
Income polarisation, expenditure and the Australian urban middle class
Authors: Wiesel Ilan , de Bruyn Julia , Meekes Jordy , Chandrashekeran Sangeetha
Published: April 2023

Recent years have seen growing concern about the ‘hollowing out’ of the middle class, due to processes of polarisation. In this paper, we examine different conceptualisations of polarisation, and introduce the concept of expenditure-adjusted polarisation that considers not only income, but also various key categories of expenditure at a household level: housing, groceries and meals, transport and energy. Analysing longitudinal data from the Household, Income and Labour Dynamics in Australia Survey, we show that the Australian society is significantly more polarised, with fewer middle-income households, when the relative size of income groups in a given year is based on expenditure-adjusted income rather than pre-expenditure income. Such polarisation is particularly prominent when housing expenditure is considered and has distinctive spatial patterns. In contrast, our analysis finds no evidence of a temporal pattern of polarisation in Australia between 2005 and 2019, with no substantial change in the size of income groups over time, regardless of which income measures are used. We argue that a more nuanced conceptualisation of polarisation, and its relation to processes of ‘hollowing out’ and rising inequality, is needed to inform urban scholarship and policy.