bluuebunny/crossref_metadata_2025 huggingface dataset:
DESASTRE AMBIENTAL NO NORDESTE BRASILEIRO
Authors: Arruda Marília , Trevizan Ana Flavia , De Andrade Laís Melo
Published: July 2024

Nos últimos anos, o mundo se depara com o aumento dos desastres ambientais naturais ou provocados pelas atividades humanas, chamadas de antrópicas. O litoral do Nordeste do Brasil, desde agosto de 2019, padeceu com derramamento de óleo, que atingiu 11 estados, em quatro mil quilômetros de costa, sendo considerada a maior catástrofe do tipo já ocorrida. Após três anos do acontecimento, com reincidência do derrame em junho de 2022 o óleo se alastrou por 1.009 localidades, sendo retirado por voluntários o total de cinco mil toneladas de óleo e resíduos oleosos, resíduos perigosos de classe I, causando a mortandade de centenas de animais e poluindo 59 Unidades de Conservação e importantes ecossistemas. Este estudo adota a metodologia qualitativa-descritiva utilizando a revisão bibliográfica e legislativa sobre catástrofes, além do estudo de caso sobre o derramamento de petróleo no Nordeste brasileiro. Demorou muito tempo para se identificar o responsável por esta catástrofe ambiental, ainda sem punição. Foi detectada negligência a nível institucional no acionamento do Plano Nacional de Contingência para conter a catástrofe e a gestão e destinação dos resíduos é incerta. As notícias são desencontradas, tanto do governo quanto dos meios de comunicação, e o país se torna condescendente neste crime ambiental sem precedentes e que tem se repetido recorrentemente.
Enzo Catarsi: il Maestro dell’etica delle relazioni nei luoghi dell’educazione
Authors: Falaschi Elena
Published: July 2024

This paper offers an interpretative reading of Enzo Catarsi’s pedagogical thought by proposing a specific focus on the ethical and aesthetic dimensions of human relations in places of education. Through a number of “excerpts” taken from Enzo Catarsi’s extensive scholarly production, several recurring themes are presented that accompanied his teachings and that represent, today, a cultural heritage of great educational depth for its current and future-oriented characters. The secrets of Enzo Catarsi’s legacy are found in democratic commitment and the courage of utopia. These professional behaviors represent the founding foundations of a broader a pedagogical horizon consisting of specific educational actions to be supported and implemented: teaching as encouragement, the role of affects, emotions and empathy, art and passion, the importance of recognition through an authentic gaze and the engagement to supporting processes of transformation, evolution and growth.
Valorizzare il territorio nella prospettiva del bene comune: l’esperienza trentina
Authors: Daddi Denise , Fruet Caterina
Published: July 2024

The article explores the holistic and circular approach adopted in the Trentino region to promote human ecology, enhance the territory, and ensure children’s well-being. The participatory model, grounded in empathy and sustainability, advocates for the valorization of the territory. Introduced actions foster children’s emotional connection with the region and encourage collective responsibility. The Autonomous Province of Trento and the social cooperative Città Futura, by committing to sustainable development and supporting local small businesses, contribute to the formation of resilient communities focused on collective well-being, reflecting a profound commitment to human ecology and territorial enhancement.
Dalla prima infanzia ai secondi “mille giorni di vita”: la trasformazione adolescenziale e le sue caratteristiche di “rinascita”. Il ruolo dell’educazione e della formazione
Authors: Mancaniello Maria Rita
Published: July 2024

The pedagogical focus on the first thousand days of life to which Professor Enzo Catarsi has devoted many of his studies and research is inseparably linked to my studies on adolescence and the paradigm of catastrophe on which I have focused much of my pedagogicalwork. The analysis on adolescence proposed herein finds its premises in the studies on dynamical systems of the mathematician Renè Thom, offering us, in an analogical sense, a possible interpretation of the meaning that pubertal change takes on in the child subject and allows us to understand the depth of the transformations experienced by the adolescent, characterised by qualitative leaps and the irreversibility of the changes gone through. A process of redefinition of the subject that is comparable to a new birth and requires specific educational attention in order to be meaningfully accompanied in this profound inner revolution and supported in such a difficult existential metamorphosis.
Evaluation of Balanced Fertilizer Types and Validation of Soil Fertility Map-Based Fertilizer Recommendation for Bread Wheat Production in Bale Highland Southeastern Ethiopia
Authors: Defar Tesfaye Ketema , Diriba Mulugeta Eshetu , Telila Regassa Gosa , Gemechu Girma Getachew
Published: July 2024

The optimal and appropriate fertilizer recommendation packages for all crops considering the improvement in productivity of small-scale farmers in the country. To evaluate the impact of blended fertilizer on wheat output, a field experiment using a five-treatment, three-replicate RCBD design was carried out during the 2020–2023 cropping season at Bale Highland southeastern Ethiopia to evaluate balanced fertilizer types and validation of soil fertility map-based fertilizer recommendation for Bread Wheat production The treatment 1Control (without fertilizer)2 (100 kg/ha-1 Urea )3 (100 kg /ha-1 NPS plus 100 kg of urea)4(100 kg /ha-1 NPSB plus 100 kg of urea) 5(100 kg /ha-1 NPSZnB plus 100 kg of urea). The plot size was 3m by 3 m (9 m2) and the spacing between plots and blocks was 1m and 1m, respectively in comparison to the control, The application of 100 kg ha-1 NPSZnB + 100 kg ha-1 urea in Bale Highland produced the highest and most significant yields of grains (5257.51 kg ha-1) the least amount of grain (3006.51 kg ha-1) in Bale Highland at the same time. To improve the production of wheat in the study area, farmers in Bale Highland must apply NPSZnB, with a similar agroecology.
The Church and Music Ministry
Authors: Fasipe Emmanuel Olusola
Published: July 2024

The music ministry is an invaluable ministry of the church. A church music ministry exists to develop a comprehensive music programme that ministers to all areas of the church’s life. An effective music ministry, therefore, provides the church with good music that members may use for worship, education and evangelism. The study adopts literary and theological approaches and engages pertinent scholarly literature. It discusses the value of music ministry to the congregation, the choir, the instrumentalists who play musical instruments and individuals who lead in the ministry. Furthermore, the study examines the various activities of the music ministry and factors that must be considered when organising a church’s music ministry. Finally, the paper discusses the criteria for enlisting leaders and workers for the music ministry. The study concludes that an effective music ministry must be put in place if the church music will be functional within the church.
Clinical Study of HELLP Syndrome and It's Outcome at Pravara Rural Hospital, Loni
Authors: Isser Dr Pragya , Borawake Dr Sai
Published: July 2024

Background: HELLP syndrome, a severe pregnancy complication characterized by hemolysis, elevated liver enzymes, and low platelet count, occurs in 0.5 to 0.9% of all pregnancies and in 10–20% of severe preeclampsia cases. It poses significant risks to both mother and fetus, presenting diagnostic and therapeutic challenges. Patients often experience epigastric or right upper quadrant pain, hypertension, proteinuria, fatigue, nausea, vomiting, sudden weight gain, and headaches. HELLP syndrome typically occurs in the second and third trimesters (27-37 weeks) and 15–30% of cases present postpartum. The exact causes remain unclear but may involve placental origins, autoimmune factors, gene mutations, or fatty acid oxidation disorders. Aims and Objectives: To analyze the clinical profile of HELLP syndrome cases and to assess maternal and perinatal outcomes, including morbidity and mortality. Material and Methods: This prospective cross-sectional study was conducted in the Obstetrics and Gynecology department at Pravara Rural Hospital, Loni, involving 45 patients with severe preeclampsia and eclampsia above 28 weeks of gestation diagnosed with HELLP syndrome. Patients were admitted to the ICU, and detailed histories and examinations were recorded. Patients were divided into two groups: those with HELLP syndrome (Group A) and those without (Group B). Results: Group A had a higher representation in the 20-22 age bracket, while Group B had more members aged 22-24. Cesarean sections were more common in Group A, whereas vaginal deliveries were more frequent in Group B. Blood pressure readings were higher in Group A. Maternal complications, such as abruption placentae, DIC, hepatic infarction, acute renal failure, and ascites, were more frequent in Group A, as were neonatal complications like IUGR, preterm delivery, neonatal thrombocytopenia, and RDS. Conclusion: The study reveals significant differences between patients with and without HELLP syndrome. Group A included younger patients, more first-time mothers, and a higher incidence of complications and mortality. These findings highlight the need for tailored management strategies for severe preeclampsia/eclampsia, especially in those with HELLP syndrome, to improve maternal and neonatal outcomes.
Evaluation and Treatment Strategies for Infertile Patients with Diagnosed Polycystic Ovary Syndrome (PCOS)
Authors: Choudhury Jafrin Yasmin , Elora Dr. Nahid , Akther Dr. Habiba , Chowdhury Dr. Jakia Jahan , Bilkish Dr. Umme Sayeda , Jaigyrder Dr. Mustofa Khalid Ahmed
Published: July 2024

Background: PCOS is the most common endocrine disorder in women that can lead to a variety of ailments associated with chronic anovulation and hyperandrogenism, it is also still a common cause of infertility in women. It is the most frequent endocrine and metabolic disorder among reproductive-aged women. PCOS (polycystic ovarian syndrome) is the most frequent cause of anovulatory infertility, accounting for more than 75% of all cases. This widespread problem affects around one in every six marriages and has a variety of causes across countries and social groups. Aims and Objective: The objective of this study was to evaluate the treatment strategies for infertile patients with diagnosed Polycystic Ovary Syndrome (PCOS). Material and Methods: This study looked at 80 cases of infertility caused by polycystic ovarian syndrome. From August 2021 to July 2022, this study evaluated 80 cases of infertility with PCOS at a tertiary medical college. The diagnosis was made using a hormone assay, ultrasound, and laparoscopy. Treatment options included clomiphene citrate, letrozole, and laparoscopic ovarian drilling. Results: In our study, the majority (50%) were between the ages of 26 and 30 years old, and 100% of patients complained of infertility, with 66.25% being of the primary type. Menstrual abnormalities affected 73.75% of women. The LH: FSH ratio was greater than 1.6 in approximately 85% of responders, and 77.5% of women had enlarged polycystic ovaries. Clomiphene citrate had a conception rate of 24%, Letrozole 31% had a rate of 20%, and laparoscopic ovarian drilling followed by Letrozole had a rate of 60%. Conclusion: Polycystic ovarian syndrome is a complex illness that necessitates a variety of treatment techniques based on the reason a patient seeks treatment. Aside from diet and fitness improvements, most patients with good conception rates require lifestyle modification treatment such as C/C and laparoscopic ovarian drilling.
Erectile Dysfunction in Adults: A Review of Neurological Causes and Risk Factor Analysis
Authors: Saadi Dr. S M , Fariha Dr. Rehnuma Taher , Jui Dr. Rabeya Sultana , Sadlee Dr. S M , Majumder Dr. Pijush , Rouf Dr. Muhammad Abdur , Roy Dr. Biplob Kumar , Islam Dr. Md. Nazrul , Sarkar Dr. Amitabh
Published: July 2024

Erectile dysfunction (ED) is a prevalent condition affecting adult men globally, characterized by the inability to achieve or maintain an erection sufficient for sexual intercourse. Neurological causes, including multiple sclerosis, Parkinson's disease, ischemic stroke, congenital spinal abnormalities, and spinal cord injuries, disrupt neural pathways essential for erectile function. Additionally, chronic conditions such as diabetes mellitus, hypertension, hyperlipidemia, and cardiovascular diseases, along with lifestyle factors like smoking and alcohol consumption, exacerbate ED by compromising vascular health. Psychological stressors further complicate the etiology of ED. Pelvic surgeries, cavernous nerve injuries, and certain medications, including antihypertensives and antidepressants, contribute to ED progression. Effective management requires addressing these neurological, vascular, hormonal, and psychological factors, necessitating a multidisciplinary approach involving specialists such as neurologists, urologists, endocrinologists, and mental health professionals. This review highlights the complex interplay between neurological disorders, systemic conditions, and lifestyle factors in the pathophysiology of ED, emphasizing the need for tailored treatment strategies targeting the underlying contributors to improve patient outcomes.
Assessment of the Antimicrobial Sensitivity Pattern of Bacterial Pathogens Causing Uncomplicated Urinary Tract Infection in Female Patients at a Tertiary Level Hospital
Authors: Khanam Dr. Majeda , Sultana Dr. Anwara , Hoque Dr. Sania , Ferdous Dr. Fatima
Published: July 2024

Introduction: Urinary tract infection (UTI) is a common infectious disease which affects both, men and women. It is a significant health concern due to multidrug-resistant (MDR) organisms. Therefore, it is necessary to have a current understanding of the antibiotic susceptibility (AS) pattern of uropathogens to manage UTI effectively. Objective: This study aims to assess the antimicrobial sensitivity pattern of bacterial pathogens causing uncomplicated urinary tract infection in female patients. Methods: A prospective study was conducted at the Department of Pharmacology & Therapeutics in collaboration with the Department of Microbiology at SBMC, the Outpatient Department of Medicine, and Gynae & Obstetrics at Sher-E-Bangla Medical College, Barishal, Bangladesh, from January 2017 to December 2017. Clean catch midstream urine samples were collected and processed using standard guidelines for microbiological procedures. Positive microbiological cultures were found in 200 of the 314 patients, Data on socio-demographic, clinical, and risk factors were collected using a structured questionnaire. Results: In this study, the age of the subjects ranged from 15 to 75 years, majority of subjects (38.4%) belonged to age group of 45-60 years. The mean age was found 42.6±11.4 years. Out of 200 cases, E. coli was the most predominant gram-negative bacteria. Antibiotic susceptibility testing revealed that the pathogenic bacteria isolated from urine samples were MDR organisms. Aminoglycoside antibiotics such as Amikacin and gentamycin were the most effective drugs. Conclusion: Urinary tract infections are prevalent, affecting 64% of cases, with all isolates showing resistance to commonly used antibiotics. Therefore, it is recommended to provide health education on the transmission and causes of urinary tract infections.
Inequality and Identity in Contemporary Processes of Labour Market Restructuring
Authors: Forsyth Andrew C.
Published: July 2024

Contemporary processes of labour market restructuring have resulted in increasing social and spatial inequalities in the United Kingdom. While the well-discussed issues of class, race and gender continue to be correlated to inequality, the decline in numbers of manufacturing jobs and rise in low-level service work has brought a new reality of identity-correlation. To remain employed, workers must increasingly present an identity that is appealing to employers: one that transcends geography and current job role. Thus, in today’s labour market with its increasing economic polarisation, previously strong social and work identities are challenged by the logic of capital.
“Bigly” Interpellations
Authors: Hanson David O.
Published: July 2024

The election of Donald Trump to the presidency sent shockwaves throughout the political sphere both domestically and internationally. The intrusion of such a volatile and abnormal political figure led to lacklustre analyses of the populism that buoyed his rise. This article will show how American populism is both a direct reaction to and an outcome of a dominant ideology upheld by the institutionalised American political class. After first outlining what type of ideological framework will be utilised, this article will then show how Trump is a symbolic representation of the crisis that American ruling ideology is undergoing.
“You’re never coming back you goddamn bastard!”
Authors: Lewis Jamie
Published: July 2024

Don Coscarelli’s 1979 sci-fi horror film Phantasm essentially depicts Mikey and his older brother Jody’s battle against, and eventual defeat of, an extraterrestrial undertaker: the Tall Man. Ultimately, it is revealed that Jody is in fact recently deceased and the entire plot was Mikey’s fantastical nightmare, the product of his grieving imagination. One scene’s use of sound is analysed here for its effectiveness in concisely tying together the disparate strands of Mikey’s subjective experience. Through the use of hushed dialogue, relational silences—particularly in relation to music—and the strategic repetition of doors being slammed, the soundtrack of this extract functions to elaborate upon the subthemes of sibling affection, abandonment, and ultimately profound terror. The audience is thus led through numerous stages of Mikey’s emotionally unstable psyche: from comforting relief, to deep distress, and finally fear.
withdrawal from Empire
Authors: Locke Henry
Published: July 2024

English post-war immigration has a turbulent history. Surprisingly, directly after the war, immigrants were mostly welcomed into English society with Polish, Irish, and Italian communities forming across the country. This began to change by the 1950s after the arrival of HMT Empire Windrush into Tilbury docks saw the first immigrants from outside Europe taking up their rights as a British Citizens to emigrate to the centre of the Commonwealth. “White Riots” broke out across the country in the latter half of the 1950s as traditionally white English communities began to fear what they saw as a “disrupting coloured invasion of their identity”. This caused a political backlash and saw the pushing through of the Race Relations Acts of 1965, 1968, and 1976 through parliament which outlawed various racial prejudices and discrimination on grounds of colour, race, ethnicity or national origins. Ultimately, the friction caused by increased immigration reached a crashing crescendo in 1968 with Enoch Powell’s “Rivers of Blood” speech which was met with vocal support up and down the country. Today, immigration, and the political and social connotations that come with it, are an accepted part of societal life. This article aims to show how and why this came about and the disruption this caused for English society; tracing the timeline of immigration from directly after the Second World War to the early 1970s.
Regressive Modernity?
Authors: Healey Euan
Published: July 2024

Modern: a byword for new, sleek, or desirable. This paper discusses the origins of Western modernity and argues that contemporary understanding frequently ignores the painful past which has allowed for a modern world to exist. This essay argues that what we consider the hallmarks of modernity and the capitalist economy originated not in Europe but in the plantations of the Caribbean, discussing and contextualising these oft-ignored colonial roots.
Religious Retribution through Football in Scotland
Authors: Burns Eva
Published: July 2024

This paper sheds light upon the conflicting, religious undertones of the two largest football clubs in Scotland, Rangers Football Club and Celtic Football Club, that is fuelled by the fanbases’ cultural dependencies within each association. These football clubs, known nationally across Scotland, have an established conflict of ideologies; beliefs that go far behind the goals of the football pitch. The main thrust of this paper, then, displays a compelling focus on the self-identity established through sport, and in this instance, football, while so too heightening the pertinence of the politics within this playing field.
A Critical Discussion of the Relationship Between Processes of Spatial Transformation and Youth Gang Activity in Denver
Authors: Deák Janka
Published: July 2024

Denver, Colorado is one of the most rapidly gentrifying cities in the United States. Case studies of gentrifying cities, including Chicago and Los Angeles demonstrate a relationship between urban restructuring and the emergence of youth gangs. However, this phenomenon is under-investigated in Denver. Drawing on an integrative literature review, this paper engages in a critical discussion of the relationship between processes of spatial transformation and youth gang activity in Denver. The contestation of urban space is identified as a central contributor to rising rates of gang criminality in the city’s gentrifying areas. These findings highlight the significance of community activism in popular resistance to gentrification and the protection of residents’ rights to the city.
Political representation and revolution
Authors: Grant James A.
Published: July 2024

At the heart of the idea of constitutionalism lies a paradox: on the one hand, the legitimacy of governmental power rests on the consent of individuals; on the other, such consent can only be expressed indirectly through already-established institutional forms. The political will, whether as a product of political representation, or as a rare moment of revolution, seems to be in a relationship of mutual antagonism with individual liberties. But if the moral reasoning underlying rights can only be the product of politics, then it is clear that politics must prevail over law and constitutional reason.
How has NATO enlargement impacted on NATO-Russia relations?
Authors: Disney Tom
Published: July 2024

Relations between NATO and the Russian Federation have been turbulent, particularly since the end of the Cold War and the ‘second wave’ of NATO expansion. Despite some initial evidence of cooperation between the two, this has not been present in the majority of cases, and Russian concerns have often been sidelined. Vital in understanding this relationship is the attitudes of both to the Baltic States, and the strain that their status brought to early Russo-NATO engagement. Indeed, perhaps the greatest tension has been caused by NATO expansion into those states, illustrating a central concern in contemporary international society.
Transitions in the Avant-garde
Authors: Wadsworth-Jones Emma
Published: July 2024

Written on the cusp between two movements, El Incongruente by Ramon Gómez de la Serna eloquently illustrates the transition between Dada and Surrealism. Utilising key Dadaist principles – such as the renunciation of logic, chance combinations of chapters and the juxtaposition of contradictory imagery – combined with Surrealist elements such as a focus on dreams and the passing of time, Gómez de la Serna constructs the puzzling world in which Gustavo lives. El Incongruente breaks with literary tradition eulogizing Dadaist elements whilst still representing the harbinger of Surrealism.
Sufficient to have stood, or supposed to fall?
Authors: Edwards Emily
Published: July 2024

Milton’s decision to anthropomorphise God by portraying him as a character in Paradise Lost has caused endless debate amongst critics. Many decry the attempt to humanise and understand the unknowable, but I intend to argue that Milton’s efforts allow the reader to engage with a theological position. By giving God the power to speak, Milton opens up the possibility for discussion. This article will challenge the perception of a perfect God in Paradise Lost and, incorporating theological and literary criticism, advance the argument that God was guilty of deliberately creating a world that was bound to fall through an investigation of his justified voice.
Moving Through Ruins and Encountering Entropy in the Horizon Video Games
Authors: Lowder James
Published: July 2024

Ruins are increasingly sites of interest in popular culture and scholarly settings, with recent academic thought surrounding ruination frequently crossing disciplinary lines. This includes work by human geographers reflecting on their experiences of walking through ruinous landscapes. By turning attention to the work of Tim Edensor and Jonathan Brettell, this article considers their ideas in the context of contemporary video games, using textual analysis to unpack the fantastical futures of Guerrilla Games’ Horizon Zero Dawn (2017) and its recent sequel Horizon Forbidden West (2022). Horizon Zero Dawn has been described as a ‘techno-fantasy’ (Maher n.p.), blending elements from classic fantasy novels and post-apocalypse film (Hudgins n.p.). These open-world role playing games are set in a post-apocalyptic United States, amidst landscapes strewn with debris left behind by the Old Ones. The player takes control of an outcast named Aloy, who sets out to solve the mysteries of the Old Ones and their technology, all while directing her on quests through a world overrun by strange animal-like machines. In considering the ruins of the Horizon games, this article develops the ideas of others: “that ruins might be one avenue through which to detect critical potential in games” (Fraser 178). On the whole, this article examines how Edensor’s and Brettell’s experiences of ruins compare to those in computer-generated settings, while thinking more broadly about the differences and similarities between physical and virtual ruins. In doing so, specific attention is given to how players traverse Horizon’s ruins, how game design curates the players’ experiences of ruination, and how encountering entropy provides an opportunity to reflect upon the future. Beyond these discussions, this article works to demonstrate the utility of fantasy media in interdisciplinary work, arguing that Horizon offers players an opportunity to engage with distinct entropic landscapes and to reflect on Earth’s ecological well-being.
A Comparative Study of Performance Appraisal Systems of Two Private Commercial Banks
Authors: Muhammad Bakhtear Uddin Talukdar , Sampa Saha
Published: July 2024

Organizations need to evaluate their employees in a timely manner to determine the lack of rightwardness in the employees’ effort. By doing so an organization can reward its employees by giving promotion and other pecuniary and non-pecuniary benefits. On the contrary, it can punish its employees depending on some strict performance measuring criteria. This study tries to compare the performance appraisal system of a local bank with that of a multinational bank. Both banks are using quantitative and qualitative performance appraisal criteria. Although objective factors do matter, judgmental approach is widely used by both banks in their performance evaluation system. Immediate boss plays a significant role in deciding the fate of the appraisee. It has been seen that though there exists a good performance appraisal system in both cases, good amount of training and counseling still necessary for both the appraiser and the appraisee.
Application of Robust Regression and Bootstrapping in Purchasing Power Parity Analysis
Authors: A. A. M. Nurunnabi , Mohammed Nasser
Published: July 2024

This article is an attempt to show how robust regression, a computer based statistical technique introduced by P.J.Huber in 1973 and later developed by Rousseeuw (1984), Rousseeuw and Yohai (1984), and many others, can helps us in cases where OLS totally fails due to outliers, leverage points and non-normality of error distribution. To infer from the estimators obtained from robust regression we generally need, especially for small samples, bootstrapping (resampling) technique that is also a computer intensive statistical technique introduced by Efron (1979), and later developed in many directions. This talk illustrates the whole thing by an example using data extracted from the Big Mac. Index with a purchasing power parity analysis.
Combination Of Lymphocyte Count and Albumin Concentration As A New Prognostic Biomarker For Gastric Cancer
Authors: Topal Uğur , Yalav Orçun , Yavuz Burak , Eray İsmail Cem , Ülkü Abdullah , Sakman Gürhan , Parsak Cem Kağan
Published: July 2024

Aim
This research links systemic inflammation and nutritional status with gastric cancer prognosis and postoperative outcomes.
Methods
Patients undergoing total gastrectomy for gastric adenocarcinoma (2015-2018) were categorized into two: Low Lymphocyte–Albumin(LA) score (Group 1) and High Lymphocyte-Albumin score (Group 2). Demographics, clinical data, operative outcomes, and survival rates were compared. The LA score's predictive ability for lymph node positivity was assessed.
Results
Using a cut-off value of 6069.7, Group 1 had 59 patients (low value) and Group 2 had 45 (high value). Hospital readmissions due to wound infections were higher in Group 1 (16.9% vs. 2.2%, p=0.041). Both groups had similar tumor localization and total lymph nodes removed, but Group 1 had more positive lymph nodes (4 vs. 2, p=0.026). Survival rates were comparable (32.59 vs. 31.32 months, p=0.390).
Conclusion
Low LA scores correlate with a higher number of positive lymph nodes, serving as a postoperative quality assessment indicator.
Testicular Sperm Extraction in Non-Obstructive Azoospermic Patients with Sertoli Cell-Only Syndrome Testicular Histology
Authors: Kayra Mehmet Vehbi , Özer Cevahir
Published: July 2024

INTRODUCTION: Sertoli cell-only syndrome (SCOS) is a prevalent cause of non-obstructive azoospermia (NOA) in males, where seminiferous tubules exclusively contain Sertoli cells, leading to minimal or absent spermatogenesis. Success rates for sperm retrieval in these cases vary significantly. We aimed to investigate the sperm retrieval rate with microdissection TESE (mTESE) in NOA patients with SCOS testicular histology and the factors that may affect it.
MATERIAL AND METHODS: Patients who underwent mTESE due to NOA were retrospectively evaluated. Only patients with a histopathological diagnosis of SCOS were included in the study. Those with other histopathological diagnoses, those who underwent conventional TESE (cTESE) were excluded from the study. The sperm retrieval rate after mTESE was calculated for patients with a pathology result of SCOS. The age, testicular volume, and Follicle-Stimulating Hormone (FSH) level of the groups with and without sperm were compared.
RESULTS: In our study, 186 patients with testicular histopathology diagnosed as SCOS were included. The rate of sperm retrieval after TESE in these patients was 28%. In patients with retrieved sperm, the mean age was 33.8 ± 5.4 years, the mean testicular volume was 11.1 ± 6.3 ml, and the mean FSH level was 22.5 ± 12.7 mIU/ml. In patients without retrieved sperm, the mean age was 33.8 ± 6.1 years, the mean testicular volume was 10.3 ± 6.1 ml, and the mean FSH level was 21.0 ± 9.8 mIU/ml. There was no significant difference observed in mean age, testicular volume, and FSH level between the group with retrieved sperm and the group without retrieved sperm (p=0.97, p=0.24, p=0.38, respectively).
CONCLUSION:
The findings of our study can be used for counseling men with NOA. Obtaining intratesticular sperm is possible in the presence of NOA and a diagnosis of SCOS histology. Therefore, patients undergoing testicular biopsy with TESE for histological examination can simultaneously prepare for intracytoplasmic sperm injection if sperm is found.
The Influence of Genetic Polymorphisms on Warfarin Dosage Requirements in Cardiac Valve Surgery Patients
Authors: Badak Tolga Onur , Cereb Ferid , Uçak Hacı Ali , Uncu Hasan , Özalp Özge , Anlaş Özlem
Published: July 2024

Aim: Warfarin, a widely prescribed anticoagulant, exhibits considerable variability in patient response, making its clinical use challenging due to a narrow therapeutic window. This study aimed to evaluate the prevalence of CYP2C9 and VKORC1 gene polymorphisms in a cohort of 87 Turkish patients who underwent cardiac valve surgery and received warfarin therapy, as well as to assess their impact on warfarin dosage requirements.
Methods: The frequencies of CYP2C9 and VKORC1 polymorphisms were analyzed, and patients were stratified based on the presence or absence of mutations affecting warfarin dosing.
Results: Revealed that patients carrying at least one CYP2C9 or VKORC1 polymorphism required a significantly lower weekly warfarin dose to achieve the optimal international normalized ratio (INR).
Conclusion: This study highlights the critical role of genetic factors in determining warfarin dosage and supports the integration of pharmacogenetic testing into clinical practice to personalize warfarin therapy. Such an approach has the potential to enhance treatment outcomes and minimize the risk of adverse events. Further research involving larger sample sizes and diverse patient populations is warranted to validate these findings and refine the current understanding of the genetic determinants of warfarin dosing.
Impact of Fast Fashion on Traditional Retail: A Comprehensive Analysis
Authors: Sathiyaseelan Yamla , S. Veshaleni
Published: July 2024

In recent times, the fashion industry has transformed unprecedentedly with the introduction of fast fashion. This research study analyses the multifaceted impact of fast fashion on traditional retail. Here, the analysis is carried out comprehensively based on micro and macro perspectives. This study has considered five fashion entities, out of which three are fast fashion and two are retail industries that play a crucial role in the fashion industry across the globe. A case study has also been presented on the selected brands’ weekly sales analysis. Finally, this research summarizes the selected industries operational roles and analyses the resultant consequential efforts on production, supplier dynamics, and consumer behaviours by comprehending the fast fashion industry and its implications on the retail industry.
ESTRATÉGIAS DE MANEJO CLÍNICO NO TRANSTORNO DE DÉFICIT DE ATENÇÃO E HIPERATIVIDADE: ABORDAGENS FARMACOLÓGICAS E TERAPIAS COMPORTAMENTAIS
Authors: Marilea dos Santos Carvalho  , Chung Won Chon  , Bene Rafael Jambo  , José Walter Lima Prado  , Daniel Barbosa Marques Silva  , Danielly Melo Brasil  , Fernanda Boni Xavier  , Francisco Neudo Rebouças Chaves  , Italo Fernando Morais de Castro  , Juliana Ribas Souza  , Lísia Maria Cruz Araújo  , Lucas Gonçalves Marangon  , Maria Manuella Vasconcelos  , Pamela Russel Machado Rocha  , Wendell Karielli Guedes Simplicio
Published: July 2024

O Transtorno de Déficit de Atenção e Hiperatividade é uma condição neuropsiquiátrica prevalente que afeta crianças, adolescentes e adultos, causando impacto significativo no desempenho acadêmico, profissional e social. Este artigo de revisão bibliográfica explora as estratégias de manejo clínico do Transtorno de Déficit de Atenção e Hiperatividade, com foco em abordagens farmacológicas e terapias comportamentais. A revisão destaca a eficácia dos psicoestimulantes, como metilfenidato e anfetaminas, bem como dos não-estimulantes, como atomoxetina e guanfacina, na redução dos sintomas do transtorno. Além disso, discute-se a importância das intervenções comportamentais, incluindo a terapia cognitivo-comportamental, treinamento de pais e intervenções escolares, que têm mostrado resultados positivos na melhoria dos sintomas e no funcionamento geral dos pacientes. A abordagem multimodal, que combina tratamentos farmacológicos e comportamentais, é enfatizada como a estratégia mais eficaz, proporcionando benefícios superiores em comparação com intervenções isoladas. A implementação dessa abordagem requer coordenação entre profissionais de saúde, educadores e familiares, e a personalização do tratamento com base nas necessidades individuais dos pacientes. Este artigo reforça a importância de uma abordagem holística e integrada para o manejo do Transtorno de Déficit de Atenção e Hiperatividade, visando melhorar a qualidade de vida dos pacientes.
RISCO DE CÂNCER DE PULMÃO NA POPULAÇÃO GERAL
Authors: Anielly Geovanna Santos Leopoldo  , Júnia Tamires Souza Vieira  , Rafael Cardoso dos Santos  , Flávia Ferreira Santana  , Sherydan Azevedo Vasconcelos  , Suede de Oliveira Neto Silva  , Paloma Gomes de Araújo Magalhães  , Cinthia Moreira de Araújo Melo  , Leone Mendes Dias  , Elisângela de Oliveira Neres  , Ive Rhayane Cangussu Leite  , Dávila Dayane Martins Souza  , Kerolaine de Freitas Moreira  , Marlete Scremin  , Amanda Alves de Jesus  , Henrique Andrade Barbosa  , Jéssica Caroline Silva Santiago
Published: July 2024

Introdução: o câncer é uma das principais malignidades responsável pelo alto índice de mortalidade da população. Com isso, analisa-se que, no Brasil, um dos principais cânceres que acometem a população é o de pulmão. Sua maior incidência está presente em ambos os sexos, mas se destaca na atualidade no sexo feminino. Entre as principais causas dessa malignidade está o uso excessivo do tabaco, além de substâncias nocivas dispersas no ambiente. O diagnóstico é realizado na maioria dos casos já avançados e a taxa de sobrevida é considerada baixa. Objetivo: avaliar a identificação do risco de desenvolvimento do câncer pulmonar na população. Metodologia: a caracterização utilizada dentro do presente estudo teve como objetivo a relação de doenças e condições de saúde associadas ao câncer de pulmão de acordo com o tempo, local e as características do indivíduo, de modo a analisar a exposição da condição associada ao desenvolvimento da malignidade, constatando as evidências em parâmetros estatísticos. Resultados: os dados avaliados demonstraram que 89,3% dos indivíduos investigados apresentaram risco baixo a moderado de manifestação da malignidade, sendo somente 7,9% em risco alto e 2,8% sem risco de desenvolvimento do câncer. Os dados foram identificados por meio de análise de estilo de vida e hábitos de vida diária. Conclusão: no desenvolvimento deste trabalho, foi possível realizar a verificação de acordo com o objetivo estipulado, com investigação dos dados para a incidência de câncer de pulmão na população, contudo as informações em bases de dados ainda são escassas, o que dificultou a análise máxima da amostra.
IMPACTO DOS FATORES DE RISCO CARDIOVASCULARES NO DESENVOLVIMENTO E RUPTURA DE ANEURISMAS CEREBRAIS: UMA REVISÃO INTEGRATIVA
Authors: Denise Krishna Holanda Guerra  , Chung Won Chon  , Bene Rafael Jambo  , Bruno Griggio  , Danielly Melo Brasil  , Emilly Louise Rodrigues Oliveira  , Gusthavo de Almeida Petrillo Braga  , Isabella Ferreira Leite  , Letícia Bueno da Silva  , Marilea dos Santos Carvalho  , Natan Vinicius de Lima Queiroz  , Paulo Roberto Bastos Vieira Filho  , Rafael Tedesco
Published: July 2024

Os aneurismas cerebrais representam uma condição neurológica grave que pode levar a hemorragias intracranianas fatais. Este estudo tem como objetivo investigar o impacto dos fatores de risco cardiovasculares no desenvolvimento e ruptura de aneurismas cerebrais. Utilizou-se uma revisão integrativa para sintetizar pesquisas publicadas entre 2019 e 2023, abordando hipertensão, dislipidemia, tabagismo e consumo de álcool como fatores de risco. A seleção de estudos foi realizada em bases de dados como PubMed, Scielo e Google Scholar, incluindo artigos em inglês e português. Foram analisados qualitativamente os dados extraídos, identificando os principais fatores de risco e seus mecanismos fisiopatológicos associados, além das abordagens preventivas e terapêuticas. Os resultados indicam que a hipertensão aumenta o estresse hemodinâmico nas paredes arteriais, contribuindo para a formação de aneurismas. A dislipidemia promove a inflamação e a degradação da matriz extracelular, enquanto o tabagismo e o consumo de álcool exacerbam esses efeitos. Técnicas avançadas de imagem, como CTA e MRI, são essenciais para o diagnóstico precoce e o monitoramento dos aneurismas. As intervenções terapêuticas incluem embolização endovascular e stents redirecionadores de fluxo, que oferecem opções minimamente invasivas eficazes. Conclui-se que a combinação de prevenção, diagnóstico precoce e tratamento inovador pode reduzir significativamente a incidência e as complicações dos aneurismas cerebrais. Estratégias de saúde pública devem focar na educação sobre fatores de risco e na equidade de acesso aos cuidados de saúde.
EFFICIENCY OF BIOCONVERSION OF NUTRIENTS AND FEED ENERGY INTO MEAT PRODUCTS BY SHEEP OF DIFFERENT GENOTYPES
Authors: Kosilov Vladimir , Yuldashbaev Yusupzhan , Nikonova Elena , Rahimzhanova Il'mira , Rebezov Maksim
Published: July 2024

The purpose of the study is to determine the influence of the genotype of rams on the efficiency of transformation of protein and energy of the feed ration by purebred young animals of the Romanov breed (Group I), its crosses with the Edilbaevskaya breed of the first generation 1/2 Romanovskaya × 1/2 Edilbay (II group) and the second generation 1/4 Romanovskaya × 1/4 Edilbay – ( Group III) in food protein and energy of meat products. Crossbreeds of groups II and III were distinguished by less crude protein consumption per 1 kg of live weight gain than peers of group I – by 15.9 (1.62 %) and 33.5 g (3.48 %) and energy by 3.64 (4.23 %) and 4.89 mJ (5.77 %). An advantage was noted for crosses of groups II and III in terms of the weight of edible parts of the carcass, which amounted to 5.05 (36.89 %) and 6.79 kg (49.60 %). Purebred rams of group I were inferior to crossbred young animals of groups II and III in terms of protein content in the edible part of the carcass by 0.86 (31.62 %) and 1.15 kg (42.28 %), respectively, extractable fat – by 0.82 (66.13 %) and 1.25 kg (100.8 %), energy – by 46.54 (49.01 %) and 68.30 mJ (71.93 %). All this determined the advantage of crossbred rams of groups II and III in terms of the yield of nutrients, edible parts of the carcass and energy per 1 kg of pre-slaughter live weight. For protein, this advantage was 2.49 (3.53 %) and 4.32 g (6.12 %), extractable fat – 9.86 (30.65 %) and 16.01 g (49.77 %), energy – 0.59 (23.98 %) and 0.70 mJ (28.45 %). The advantage of crossbred young animals of groups II and III in terms of the protein bioconversion coefficient was established, which was 0.26 and 0.65 % for protein, 0.21 and 0.40 % for energy, respectively. The leading position in all indicators was noted for crossbreeds of the second generation of group III.
TRANSFORMATION OF FALLOW LANDS SOILS FERTILITY IN THE FOREST-STEPPE ZONE WITH THEIR USE DIFFERENT DIRECTIONS
Authors: Sorokina Ol'ga
Published: July 2024

The purpose of research is to provide a comprehensive comparative assessment of the fertility of gray fallow soils in the forest-steppe zone of the Krasnoyarsk Region, overgrown with forest, used for hayma-king and re-developed into arable land. The studies were conducted in 2007–2020 in the Krasnoyarsk and Achinsk-Bogotol forest-steppe on gray soils of fallow lands no longer used for agricultural purposes. Stu-dies were carried out to assess the indicators of the potential and effective fertility of gray soils of fallow lands of the Krasnoyarsk and Achinsk-Bogotol forest-steppe with their various post-agrogenic use. It has been established that forests regenerated on fallow lands do not lead to degradation of soil fertility, especially in terms of the content of humus and agronomically valuable aggregates. The emerging forest litter and tree litter accelerate the accumulation of organic matter, a source of humus. There is weak spatial va¬riation in most indicators of effective and potential fertility in soils under regenerating forest compared to pure fallow lands. With the re-involvement of fallow land into arable land, nitrification somewhat increases, spatial variation in soil properties decreases, and the content of humus and absorbed bases decreases. The structural composition of the soils of all study objects is characterized as excellent (ACF 88–77 %) with an insignificant value of the coefficient of variation of fractions (4–7 %). When reclaiming fallow lands into arable land, the proportion of the blocky fraction is significantly reduced. The spatial variability of the structural composition of soils in fallow lands and hayfields is higher than on arable land, which is asso¬ciated with the “clumpiness” of the ground cover and root system of plants on uncultivated soils. In terms of fertility, post-agrogenic gray soils used for haymaking occupy an intermediate position between clean fallow lands and those overgrown with forest. The productivity of the phytomass of fallow lands, arable land and hayfields in the Krasnoyarsk and Achinsk-Bogotol forest-steppe is more closely correlated with the indicators of the potential fertility of post-agrogenic gray soils. In most cases, the values of the correlation coefficients are closer between phytomass reserves and indicators of effective fertility in the Achinsk-Bogotol forest-steppe, which is associated with more favorable hydrothermal conditions in this research area and optimal water-physical properties.
Household science: a new occupation for women?
Authors: Oakley Anne
Published: July 2024

An educational and social movement to raise the status of housework by emphasising its scientific nature developed in Europe, North America and other countries in the period from around 1880. This has mostly escaped the attention of scholars, who have failed to see how cleaning up homes and improving domestic nutrition could have an impact on public health. This article focuses chiefly on another aspect of the household science movement: its consequences for women’s work both inside and outside homes. Notions of scientific efficiency and improved house design, together with attention to the poor working conditions of housewives had a lasting effect on the way housework was done. New housework technologies created professional opportunities for women on the fringes of the scientific/technical world.
The neurobiological mechanism underlying ketamine’s rapid-acting antidepressant effect
Authors: Yin Yingying , Yuan Yonggui
Published: July 2024

Depression is one of the most common disabling mental disorders. However, first-line treatments for depression are typically slow-acting. Ketamine, a glutamatergic modulator with rapid antidepressant effects, has proven effective in treating both refractory depression and suicidal tendencies. The neurobiological mechanisms underlying the effects of antidepressants have become a research hotspot; yet, the exact processes remain unclear. Brain imaging studies have provided important evidence from macroscopic perspectives, such as brain structure and function, while biochemical studies have made significant discoveries from microscopic perspectives, including proteomics and genomics. Previous reviews have summarized a broad range of biomarkers related to the ketamine response, encompassing studies in imaging, electrophysiology, metabolism, immunology, genetics, and neurotrophy. In this review, we systematically summarize a number of potential biomarkers for predicting and modulating the efficacy of ketamine, from both macroperspectives (such as neuroimaging and neuroelectrophysiological markers) and microperspectives (such as neurobiochemical and genetic markers). Although research in this area is still in its infancy, these biomarkers can help clinicians identify whether ketamine intervention is needed for treatment-resistant depression, thereby reducing the burden on patients and society. However, the majority of biomarkers are still in the preclinical exploratory stage, and existing findings are limited. To realize the clinical application of these biomarkers, future studies should combine biomarkers of different types to investigate the relationships and interactions between them. This approach aims to optimize clinical outcomes by enhancing the involvement of biological targets in new models.