bluuebunny/crossref_metadata_2025 huggingface dataset:
The Guidelines for Developing the Integration of Production, Education, and Research under the Background of "Double High Plan" in Guizhou, China
Authors: Min Tang , Keyuraphan Luxana , Sutheeniran Niran , Dechhome Patchara
Published: September 2023

The objectives of this research were: 1) to study the current situation of industry-education integration under the background of the "double-high plan" in higher vocational college in Guizhou, China, 2) to develop the guidelines for industry-education integration under the background of the " double-high plan" in higher vocational college in Guizhou, China, and 3) to evaluate the adaptability and feasibility of the guidelines for industry-education integration under the background of the " double-high plan" in higher vocational college in Guizhou, China. The population of this research contained 420 teachers from four higher vocational colleges. According to the Krejcie and Morgan sampling table (1970), the sample group of this research was 201 teachers from four higher vocational colleges in Guizhou, and simple random sampling was used in this research.Furthermore, the interviewees of this research were five administrators, teachers, and industry representatives. Five high-level administrators in Guizhou were the five experts in evaluating the adaptability and feasibility of the guidelines. Purposive sampling was used in this part.The research instruments were a questionnaire, a semi-structured interview, and an evaluation form. The statistics for data analysis were frequency, percentage, mean, standard deviation, and content analysis.The results found that: 1) the current situation of industry-education integration under the background of the "double high plan" in the higher vocational college in Guizhou was government policy support, the attractiveness of higher vocational colleges, 2) The guidelines for industry-education integration under the background of the "double high plan" in higher vocational colleges in Guizhou had three dimensions: government dimension, higher vocational colleges dimension, and enterprises dimension, and 3) The adaptability and feasibility of the guidelines were at the highest level, with values ranging from 4.00 to 5.00.
OLIY TA’LIM TIZIMIDA TOʻLOV-KONTRAKT SHARTNOMALARINI INNOVATSION OPTIMALLASHTIRISHNING AMALIY YOʻLLARI
Authors: Karimov Muzaffar Abdumalik oʻgʻli
Published: September 2023

Ushbu maqolada oliy ta’lim muassasalari va ta’lim oluvchilar oʻrtasida tuziladigan toʻlov-kontrakt shartnomalarini oʻrgangan holda “Innovatsion toʻlov-kontrakt shartnoma” asosida innovatsion toʻlov mexanizmi ishlab chiqilgan. Toʻlov shartnomalarida belgilangan miqdor va muddatlar boʻyicha shartlarini taklif etilgan “Cash back” asosida innovatsion optimallashtirishga doir taklif va tavsiyalar berilgan.
KICHIK BIZNES SUByEKTLARI FAOLIYATIDA INSON RESURSLARIDAN FOYDALANISHNING METODOLOGIK ASOSLARI
Authors: A.A.Yusupov
Published: September 2023

Ushbu maqolada kichik biznes subyektlari faoliyatida inson resurslaridan foydalanishning metodologik asoslari xususida tahliliy fikr-mulohazalar bildirib oʻtilgan. Shuningdek, kichik biznes subyektlari faoliyatida inson resurslaridan samarali foydalanish jarayonlari, ularning metodologik asoslari hamda kichik  biznesni rivojlantirishga ta’siri haqida ma’lumotlar keltirib oʻtilgan. Bundan tashqari, mamlakatimiz iqtisodiyotida kichik biznes ulushi va unda inson resurslarining oʻrniga oid tahliliy yondashuvlar asosida statistik  tahlil natijalari yoritib oʻtilgan.
INFLUÊNCIA DA INTUBAÇÃO NA DEGLUTIÇÃO DE PACIENTES NEUROCIRÚRGICOS
Authors: Sales Assunção Gabryela , Andrade dos Santos de Queiroz Moisés , De Albuquerque Cabral Silva Jorgeane , Rolim Teixeira Henderson Mozart Ney , Laurindo Porto Andrea Cintia , Praça Brasil Christina Cesar
Published: September 2023

Analisar a influência da Intubação Orotraqueal (IOT) de curta duração na deglutição de pacientes pós-operatórios neurocirúrgicos. Estudo longitudinal, observacional, descritivo e prospectivo, realizado na unidade de terapia intensiva. A amostra constou de 90 pacientes, que foram submetidos ao Protocolo Fonoaudiológico de Introdução e Transição da Alimentação por Via Oral para pacientes com risco para Disfagia Orofaríngea e Protocolo de Videoendoscopia da Deglutição (VED). Os pacientes foram submetidos às avaliações entre 6-12 horas pós-extubação. Na avaliação clínica fonoaudiológica da deglutição, 80% dos pacientes apresentaram deglutição normal. O que também foi evidenciado durante a VED em 72,2% dos casos, não havendo diferença estatística entre os dois métodos de avaliação da deglutição à beira do leito. Pacientes submetidos à IOT de curto prazo apresentam possibilidade de iniciar dieta por via oral após um período de seis horas, porém com possíveis restrições quanto à consistência alimentar consumida.
Bridging the gap
Authors:   , Iqbal Ramsha
Published: September 2023

PART I
In chapter 2, the relationship between perfusion and hypoxia has been investigated with
15O-H2O en 18F-FAZA, respectively.
In chapter 3 the relationship between perfusion and proliferation with 15O-H2O and
18F-FLT was investigated.

PART II
In chapter 4A and 4B, the biodistribution of 18F-FES has been described and it has been
investigated how this is affected by rintodestrant, a novel SERD.
In chapter 5 the pharmacokinetic profile of the 18F-FES radiotracer was investigated in
patients with metastatic ER+ breast cancer.
In chapter 6 it was investigated how the diagnostic accuracy is of 18F-FDG, the radiotracer
that is currently used for staging of ER+ disease.
In chapter 7, it was investigated how 18F-FDG versus 18F-FES heterogeneity predicts response to therapy and/or allows to monitor treatment effect.
ALTERAÇÕES BUCAIS EM PACIENTES COM INSUFICIÊNCIA RENAL CRÔNICA: UMA REVISÃO INTEGRATIVA DE LITERATURA
Authors: Melo Ilana Loiola , Nogueira Luís Henrique dos Santos , Aguiar Valdelya Nara Pereira
Published: September 2023

A doença renal crônica (DRC) é determinada pela perda lenta, progressiva e irreversível da função renal ou destruição dos néfrons, sendo capaz de gerar ao paciente um quadro de síndrome urêmica, em função do aumento de substâncias tóxicas no sangue que se manifestam pela incapacidade dos rins de realizar a filtração glomerularea sua deficiência na produção de eritropoietina (ANDRADE et al., 2020). Diferentes estudos têm certificado que pacientes com DRC possuem um estado de saúde bucal ruim e necessitam uma atenção maior aos tratamentos odontológicos em relação à população em geral. Desse modo, é imprescindível que os odontólogos detenham um conhecimento sobre a função renal e suas consequências para a saúde bucal e tratamentos odontológicos (CHANG et al., 2021). Os pacientes devem realizar o seu tratamento renal levando em conta todos os problemas referentes à disfunção renal e adicionados a um exigente programa de acompanhamento até o transplante.  A detecção prévia de patologias orais e medidas preventivas podem reduzir a demanda de cuidados dentários extensos. O envolvimento do paciente é crucial para ampliar a motivação para a saúde bucal (CASTRO et al., 2017). Os exames de saúde bucal desses pacientes são necessários para que se eliminem focos potenciais de infecções odontológicas ou infecções metastáticas decorrente da cavidade bucal. São indicados para tais pacientes a execução de profilaxia e/ou raspagem e polimento radicular, instrução de higiene oral, inspeção radiográfica (radiografia panorâmica e radiografias Inter proximais), teste de vitalidade em todos os dentes e tratamento restaurador, além de procedimentos cirúrgicos. O exame inicial e o manejo ideal são capazes de fornecer uma base de comparação, quando o cirurgião-dentista pode considerar as manifestações bucais que procedem da progressão da insuficiência renal crônica (HOWEEL et al., 2016). A intervenção precoce deve ter como finalidade restabelecer a saúde oral e dentária, para diminuir o impacto das doenças orais, recompor a saúde bucal do paciente a capacidade alimentar, qualidade de vida, e precaver os efeitos que podem afetar o estado nutricional (CHANG et al., 2021).
CIRURGIA METABÓLICA COMO TRATAMENTO CIRÚRGICO DO DIABETES TIPO II
Authors: Silva Aída Lourandes Costa , Palhares André Osvaldo Melo , Valente Higor Martinho , Felix Isadora Pinheiro , Da Silva Izabela Pereira , Angioletti Lucas Félix , Melo Olívia Raquel Oliveira , Felix Victor Pinheiro
Published: September 2023

A Diabetes Mellitus tipo II (DMII) é uma doença crônica relacionada à ausência de secreção ou ao mau funcionamento da insulina, ocasionando em uma hiperglicemia severa. Devido às dificuldades clínicas existentes para o seu tratamento, a cirurgia metabólica tornou-se uma alternativa factível, uma vez que o metabolismo do trato digestivo está intrinsecamente relacionado à homeostasia da glicose. Das várias técnicas cirúrgicas, pesquisas recentes constataram maior sucesso quando realizada a técnica by-pass gástrico que tornou-se o procedimento padrão-ouro pela sua estimulação dos hormônios PYY e GLP-1. Nesse sentido, a cirurgia metabólica como tratamento para a DMII, torna-se bastante promissora e deve, portanto, ser considerada como conduta terapêutica para casos mais graves.
Публічні закупівлі в умовах воєнного стану
Authors: Петик Л. О. , Бацман І. В.
Published: September 2023

У статті розглянуто теоретичні основи системи публічних закупівель, визначено основні процеси, що використовуються при їх здійсненні. Встановлено категорії замовників, які здійснюють публічні закупівлі та основні принципи їх здійснення. Розглянуто нормативно-правові документи та зміни, які відбуваються в законодавстві у період воєнного стану, щодо здійснення регулювання закупівель. Досліджено проблеми, які існують в Україні при проведенні тендерних закупівель під час російської агресії. Подано статистичні дані проведення тендерів у системі Prozorro, з яких визначено, що до основних замовниками закупівель у 2022 році стали органи центральної влади, органи місцевого самоврядування, територіальні громади, державні та комунальні підприємства, правоохоронні структури. Крім цього показано найбільшу кількість закупівель по певних категоріях та установах. Розглянуто динаміку кількості скарг до Антимонопольного комітету за 2022 р.
IoT based Location Tracking System for Advanced Electric Vehicle
Authors:   Department of Electronics and Communication Engineering, Acropolis Institute of  Technology and Research Indore, India, Baig Imran , Awad Mukti
Published: September 2023

Abstract-The Location Tracking System is a critical component of modern technology, playing a pivotal role in various industries and applications, including transportation, logistics, emergency services, and personal navigation. This abstract provides an overview of the key components and functionalities of such a system, emphasizing its significance, challenges, and potential benefits. The system permits localization of a portable tracked unit and transmitting the position to the tracking centre. The GPS tracking system consists of portable tracked device attached to a person, vehicle or any asset, and the tracking center where the portable device's location should be monitored. The mobile tracked device receives its coordinates from the GPS and sends these coordinates as SMS via GSM modem to the tracking centre, which is simply a personal computer with many interface programs to display the location on Google maps using free version of Google Maps application programming interfaces. Keywords: Vehicle Controlling, Monitoring and Tracking, Road Network, Electric Vehicle, Smart Grid, Path Adaptation
The association between antiretroviral therapy with depression and health related quality of life in patients infected with HIV in Kasempa, Zambia
Authors: Mutimushi E. , Blackwood G. , Hachaambwa L. M.
Published: September 2023

Background: Many HIV-infected patients are accessing antiretroviral therapy (ART) in Zambia. This has enabled them to live longer. However, it is necessary to determine whether such improvements are accompanied with parallel improvements in quality of life. The purpose of this research was to determine whether ART was associated with lower levels of depression and higher levels of health-related quality of life (HRQOL).

Objectives: The primary objective was to compare the association of ART with depression and Health Related Quality of Life (HRQOL) in treatment naïve and treatment experienced patients. The specific objectives were to screen for levels of depression and HRQOL in HIV infected patients, and to compare these levels between ART-experienced and ART-na¿ve patients.

Methods: This was a cross sectional study in which 140 HIV-infected adults (70 ART-experienced and 70 ARTnaïve) in Kasempa district were enrolled by convenient sampling. Independent variables of sex, age, marital status, education and employment status were matched across the two groups to avoid their confounding effect and bias. Depression and HRQOL were screened using the Centre for Epidemiologic Studies – Depression (CES-D) and Medical Outcomes Survey – HIV (MOSHIV) tools respectively in both groups. The average scores for depression in both groups were compared using the t-test. Mental Health Summary scores (MHS) and Physical Health Summary scores (PHS) derived from the MOS-HIV tool were obtained by factor analysis and linearly transformed into a 0-100 scale. These scores were also compared between the two groups using the t-test. Multiple linear regression was used to determine the factors that were significantly associated with depression and HRQOL in both groups.

Results: The mean depression scores were found to be lower among ART-experienced clients compared with their ART-naïve counterparts with a mean difference of 7.40 (95% C.I 3.77-11.03; P < 0.0001). Overall, ARTexperienced participants had higher HRQOL scores compared with their ART- naïve counterparts with differences of 23.0 (95% C.I 16.0-30.1; P < 0.0001) and 11.2 (95% C.I 6.0-16.4; P < 0.0001) in MHS and PHS scores respectively.

Conclusion: Being ART-experienced was associated with lower depression scores and higher HRQOL scores when compared with being ART-naïve. Lower depression scores and higher HRQOL scores were associated with being male, married, single, asymptomatic and having higher CD4 counts.
CSR Program of PT Pertamina Patra Niaga FT Simeulue Community Empowerment Based Through Catfish Cultivation in Langenget Village
Authors: Dedi Krismanto
Published: September 2023

Community empowerment through catfish farming in Langenget Village is one of the Corporate Social Responsibility (CSR) programs of PT Pertamina Patra Niaga Fuel Terminal Simeulue. This community empowerment is carried out based on the results of mapping the potential and needs of the people of Langenget Village. Potential in the form of natural conditions and human resource skills can support the successful development of catfish cultivation in Langenget Village. This study aims to determine the community empowerment program through catfish cultivation and have an impact on the people of Langenget Village. The research method used is qualitative with an approach to program beneficiaries. Empowerment is carried out by providing knowledge and training to the people of Langenget Village to be able to take advantage of market opportunities so as to increase income. The training was conducted by informing about catfish farming techniques, starting from spawning to marketing strategies for harvests. The results of the study showed that there was an impact of increasing income by beneficiaries and gaining knowledge about catfish farming techniques after participating in capacity building activities.
Access to Clean Water: Towards a Healthy Society at Baturetno Subdistrict, Wonogiri
Authors: Manoy Kevin Christopher , Rini Chondro , Wibowo SFD Arie , Syaffei Ajie Dwi
Published: September 2023

Access to clean water is a basic need that must be met by all humans. Clean water is very important to improve people's quality of life, especially in improving health. Wonogiri Regency is one of the areas that often experiences drought, considering that the area is in the Seribu Hills area which has geological contours of rocky soil and it is difficult to absorb air, especially in the southern region. Kalbe as a company that cares about the importance of access to health opened access to clean water in two villages located in Baturetno District, Wonogiri, namely Watuagung Village and Boto Village. Until now, Kalbe's access to clean water has reached hundreds of heads of households, whose management is carried out through associations managed by the local community through a metering system. From the company's point of view, the satisfaction measurement results show community satisfaction with the results of opening access to clean water by Kalbe. The results of the Social Return on Investment (SROI) measurement also show that the impact of the program implemented by Kalbe exceeds the investment made at the start of the program implementation.
Empowerment of Coastal Communities Based on Environmental Management Through the Utilization of FABA
Authors: Delta Prayogi  , Zumar Bashendra Ibrahim  , Nurhidayati
Published: September 2023

Belitung Island is one of the rich islands in Indonesia that has high potential in the fisheries sector. Currently, it can't be relied upon as the only livelihood of the community for various reasons. To respond to these things, PT PJB Services PLTU Suge Belitung through the implementation of the Corporate Social Responsibility (CSR) program, can utilize FABA as waste generated from the coal combustion process into economically valuable goods. This can be an alternative activity that residents can do to add skills and fulfil their daily economic needs. The purpose of this study is to determine the effect of the implementation of FABA utilization in employment on community welfare. The research method in the implementation of CSR is carried out by cooperating with other partners, namely the surrounding community, religious education organizations, and the Government of Belitung Regency. Results of this study show that the training skills received by the community in utilizing FABA have absorbed labour and can be used as an alternative job for the coastal community of Pegantungan Village.
KRAXMALNING YELIMLILIK XOSSALARI VA JELATINIZASIYASI
Authors: Xamdamova Madina Dilmurod qizi , Asqarov Ibrohimjon Rahmonovich
Published: September 2023

Bugungi kunda kundalik ehtiyojlarimizning asosiy qismini etilen, stirol va vinil atsetat asosidagi polimerlar mahsulotlari tashkil qiladi. Ularning atrof muhit va inson organizmiga yetkizadigan zararlari o‘z isbotini topgan va aynan shuning uchun ham plastik buyumlarni tabiiy bioparchalanuvchan na’munalarga almashtirishga bo’lgan ehtiyoj juda yuqori. Ushbu maqolada plastik idishlar o‘rniga foydalanish mumkin bo‘lgan kepak asosidagi bir martalik bioparchalunuvchan idishlar tayyorlash jarayonlarida, biomateriallarning tabiiy yelimlilik xossalarini (adgeziv xossalarini) namoyon qiluvchi kraxmalning xossalari, jelatinizasiya jarayonlarining ahamiyati va tovar tarkibiga bo‘lgan ta'siri yoritilgan.
N,N1-GEKSAMETILEN BIS-[(DIBENZILAMINO)MOCHЕVINA]NING BIOLOGIK FAOLLIGINI O‘RGANISH VA SINFLASH
Authors: Xolboyev Yusubjon Hakimovich , Maxsumov Abduxamit Gafurovich , Abduraxmanov Ulugbek Kurganbayevich
Published: September 2023

Mochevina hosilalari ichidan biostimulyatorlarni izlash va ularni qo’llanilishini o’rganish maqsadida uslubiy tavsiyaga ko‘ra N,N1-geksametilen bis -[(dibenzilamino) mochevina] tarkibli mahsulot olindi. Mahsulotning eruvchanligi o‘rganildi. Biologik faolligi yuqori bo‘lganligi uchun chigit unishiga va g‘o‘za o‘simligining o‘sishiga ta’siri laboratoriya va dala amaliyoti tajribalarida sinovdan o‘tkazildi.
CHILONJIYDA МЕVАSINING KIMYOVIY TARKIBI VA UNING O’SMALARNI DAVOLASHDA QO’LLANILISHI
Authors: Xomidov Inomidin Ilmidinovich , Asqarov Ibrohimjon Rahmonovich
Published: September 2023

Xalq tilida jilonjiyda deb ataluvchi Ziziphus jujuba o‘simligi to‘yimli va shifobaxsh. U qadimdan xalq tabobatida ishlatilib kelinadi. Afsuski, saraton kasalligi keng tarqalgan kasalliklardan biriga aylanmoqda. So’ng yillarda jilonjiyda mevasidan saraton kasalligini davolashda ishlatiladigan moddalar aniqlangan. Ular triterpen organic kislotalar sinfiga mansub. Maqolada ushbu moddalarning rakka qarshi ta’siri to’g’risidagi tadqiqotlar tahlil etilgan.
Program Wakaf Tanaman Produktif perspektif Hukum Islam: Studi Program Penyuluh Agama Islam KUA Kecamatan Rumbia Kabupaten Lampung Tengah
Authors: Purnomo Robberto Purnomo , Ismail Habib , Mukhlishin Ahmad Mukhlishin , Arsyad Mufid Arsyad , Mardiantari Ani Mardiantari
Published: September 2023

Penyuluh Agama Islam Kantor Urusan Agama (KUA) Kecamatan Rumbia membuat trobosan program inovasi yaitu wakaf tanaman produktif. Program wakaf tanaman produktif dapat membantu untuk mengurangi masalah-masalah lingkungan dan ekonomi yaitu dengan cara mewakafkan harta bendanya berupa tanaman produktif. Penelitian ini bertujuan untuk menganalisis prespektif hukum Islam terhadap program wakaf tanaman yang diprogramkan oleh Penyuluh Agama Islam di Kecamatan Rumbia Kabupaten Lampung Tengah. Jenis penelitian menggunakan (field research) yang dilakukan di Kecamatan Rumbia Kabupaten Lampung Tengah dan dengan menggunakan pendekatan kualtatif yang bersifat deskriptif yaitu membuat gambaran mengenai situasi-situasi atau kejadian-kejadian mengenai permasalahan yang ada. Wakaf tanaman produktif ditinjau dari hukum Islam, wakaf tanaman produktif adalah sah asalkan peruntukkanya jelas untuk kepentingan umum dan sesuai dengan syariah dan tidak bertentangan dengan aturan. Saat ini Penyuluh Agama Islam KUA Kecamatan Rumbia yang telah melakukan penanaman sebanyak 100 wakaf tanaman produktif, dan berlokasi di Kampung Bina Karya Buana dan Kampung Reno Basuki Kecamatan Rumbia, Kabupaten Lampung Tengah yang berupa pohon Alpukat, Nangka dan Mangga.
The Role of Social Media in Enhancing English Language Proficiency
Authors: Islam Zubair Ul
Published: September 2023

In today's interconnected world, social media has emerged as a dynamic and influential platform that transcends geographical boundaries. Beyond its primary function of communication and networking, social media has increasingly played a pivotal role in the realm of education, particularly in enhancing English language proficiency. This abstract delves into the multifaceted ways in which social media contributes to the improvement of English language skills. The accessibility and ubiquity of social media platforms provide learners with a plethora of opportunities to engage with the English language. From reading articles and watching videos to participating in discussions and joining language-focused groups, individuals can immerse themselves in an English-rich environment that complements traditional language learning methods. Social media fosters interactive learning experiences. Through online language exchange partnerships, learners can connect with native speakers or proficient speakers of English, enabling realtime practice and feedback. Additionally, language learning applications and educational communities on platforms such as Facebook and Reedit facilitate collaborative learning and resource sharing. The gamification of language learning on social media adds an element of fun and motivation. Apps and challenges that encourage users to complete language-related tasks, quizzes, or word-of-the-day exercises create an engaging and enjoyable learning process. The social aspect of social media cannot be overlooked. Engaging with a global audience on platforms like Twitter or Instagram allows learners to explore diverse linguistic nuances and cultural contexts, thereby enriching their language skills. Engaging in discussions, commenting on posts, and even creating content in English contribute to language development. Social media analytics tools provide learners with valuable insights into their progress. Tracking language proficiency growth through language-learning apps or data analysis of social media interactions enables learners to set and achieve specific language goals. Social media has evolved into a powerful ally for those seeking to excel in the English language. This transformation underscores the adaptability of language learning in the digital age, opening new avenues for effective andenjoyable language acquisition.
De regelgevende bevoegdheid en het omgevingsplan: het raadsprimaat gerelativeerd.
Authors: van Karnenbeek L.J. (Lilian)
Published: September 2023

De regelgevende bevoegdheid en het omgevingsplan: het raadsprimaat gerelativeerd.

In dit artikel gaat de auteur in op de bevoegdheid van de gemeenteraad tot het stellen van regels inzake de ruimtelijke ordening en hoe de delegatiemogelijkheid van die bevoegdheid onder de Omgevingswet zich verhoudt tot het primaat van de gemeenteraad.
FROM COLONIAL PAST TO PRESENT: THE NEXUS OF SMALLPOX AND POLIO VACCINATION REJECTION IN NORTH-WESTERN NIGERIA
Authors: Abdullahi Labbo
Published: September 2023

This paper presents some historical precedents that provide a critical framework for interpreting the rejection of polio vaccination in North-western Nigeria. In this paper, qualitative content analysis of written and oral data is used to explore the genealogy of the suspicion that cloud both smallpox and polio vaccinations in the area. The main objective of the paper is to provide a critical analysis of the politics of smallpox vaccination that reveals mistrust that persists to the present. The paper observed that the people’s perception of colonial medicine and mistrust of colonial officers geared their apathy to smallpox vaccination in the zone. Traditional institutions and legislation were used to ensure the acceptance of the vaccination and this increased the suspicion when people perceived the strategy as a control mechanism than a genuine attempt to improve their public health. These memories of smallpox vaccinations have a direct impact on the contemporary polio eradication campaign. People perceived polio vaccination as a continuation of the surreptitious Western agenda. The findings of the study present that perceived mistrust of the West stands to be the significant challenge for polio eradication campaigns as it did during smallpox vaccination in the colonial era.
Comparison of MMP-9 Density Between Triple Negative and HER2 Enriched Breast Carcinoma Subtypes
Authors: Putra Pratama Eka , Dewi Citra , Aspitriani Aspitriani , Bahar Erial
Published: September 2023

Background

Matrix metalloproteinase-9 (MMP-9) is a protease that plays an important role in various biological processes of breast cancer. This marker may be useful in determining the prognosis and become a promising therapy, especially in breast carcinoma with an aggressive subtype including HER2 enriched and triple negative. Both subtypes have high MMP-9 expression, but it is necessary to differentiate them because they have different biological and molecular aspects. This study aims to compare the density of MMP-9 between triple negative and HER2 enriched breast carcinoma subtypes and their relationship with clinicopathological characteristics.

 

Methods

This is a cross sectional study using 32 samples of paraffin blocks and slides of breast carcinoma patients with triple negative and HER2 Enriched subtypes at the Department of Anatomical Pathology Faculty of Medicine Sriwijaya University/Dr. Mohammad Hoesin Hospital Palembang for the period January 1, 2016 to December 31, 2019. Each sample was stained with MMP-9 antibodies immunohistochemistry (polyclonal, Abcam). Comparative analysis of MMP-9 density between the two subtypes was carried out using the median value based on the Mann-Whitney analysis. MMP-9 density was categorized as high and low based on the ROC curve and analyzed by using chi-square test to assess its association with clinicopathological characteristics.

 

Results

Mann-Whitney test showed that the MMP-9 density was higher in the HER2 enriched subtype (median 12.0) than triple negative (median 8.8) with a p value of 0.632. The relationship distribution of high MMP-9 density was found in the category of age group >40 years old (60.0%), positive lymphovascular invasion (86.7%) and histological grade III (80.0%) with p values of 0.798, 0.402 and 0.691.

 

Conclusion

MMP-9 density in HER2 enriched subtype was higher than triple negative subtype, but statistically not significant.
Congestive Heart Failure Readmission Rates Decline After Patient Navigator Implementation in COVID-19 Era
Authors: Lauf Jason , Keller Elizabeth , Miniaci Anthony , Ramic Meghan , Forouzandeh Farshad , Hill James
Published: September 2023

Heart failure is a leading cause of hospitalizations, with a growing prevalence and a high readmission rate. Hospitalization and readmission affect both patient stress and hospital finances. The COVID-19 pandemic and broader economic conditions placed additional stress on hospitals in recent years. In response, our hospital implemented a heart failure navigator program during the COVID-19 pandemic to prevent readmissions. We monitored the readmission and mortality rates of patients hospitalized for heart failure in 2018 and 2019 (before implementation) against 2020 and 2021 (after implementation). There were 235 readmissions with 28 deaths before implementation and 156 readmissions with 17 deaths after implementation. The reduction in readmission was significant (p = .0185), with an insignificant reduction in mortality (p = .2674). This indicates that the reduction in readmission rate was secondary to navigator implementation, not patient mortality. In conclusion, a multifactorial HF navigator can reduce HF readmission, even when implemented during a pandemic that causes increased patient morbidity.
Da necessidade de políticas públicas relacionadas à inclusão sociodigital das pessoas com deficiência
Authors: Regis Arthur Henrique de Pontes , Da Cruz Gitia Albuquerque , Gonçalves Jonas Rodrigo
Published: September 2023

O tema neste estudo relaciona-se aos Direitos de Inclusão da Pessoa com Deficiência (PcD). A linha de pesquisa pautou-se no problema referente quanto às iniciativas para efetividade de fato na inclusão sociodigital deste núcleo de pessoas. É importante entender o significado das barreiras como exclusão social, para identificar se o problema referente à causa da deficiência está na pessoa ou na sociedade. O objetivo é consolidar as iniciativas de vários níveis sociais a fim de que realmente sejam viabilizadas ações inerentes a essa inclusão. Desta forma, haveria políticas públicas eficientes no Brasil. Também foi dada a importância dos investimentos governamentais e privados em pesquisas científicas nas tecnologias assistivas. Com destaque para iniciativas conjuntas entre sociedade e poder público na efetividade desse direito da inclusão sociodigital. Para que assim seja tutelado e garantido, em sentido amplo.
Estudos prospectivos da produção de queijos nacionais e do seu potencial para a indicação geográfica
Authors: Corrêa Sueli José Pereira , Barretto Lília Calheiros de Oliveira , De Oliveira Júnior Antonio Martins
Published: September 2023

Este estudo tem o objetivo apresentar o cenário da produção de queijo e o potencial deste produto para as indicações geográficas (IG), que podem ser utilizadas como uma oportunidade de inovação para esta cadeia produtiva em diversos territórios brasileiros. As seguintes bases de dados foram consultadas para a coleta de dados: Divisao de Estatísticas da Organização das Nações Unidas para Alimentação e Agricultura (FAOSTAT), Instituto Brasileiro de Geografia e Estatística (IBGE) - Censo Agropecuário 2017, eAmbrosia - Comissão Europeia, Instituto Nacional da Propriedade Industrial (INPI). Os resultados evidenciaram a Europa como o continente que possui a maior produção de queijo, possuindo 254 registros de IG para esse produto, com destaque para Itália e França. No Brasil, a região Sudeste se destaca como maior produtora de queijo e o país apresenta um total de 5 registros de IG para queijo. Foram identificados pelo Movimento Slow Food um total de 48 tipos de queijos tradicionais no Brasil. Considera-se neste estudo, a relevância setor produtivo de queijo para o Brasil e que há potencial para novas concessões de registros de IG de queijo em diversas regiões brasileiras que poderão utilizar desta estratégia de reconhecimento e valorização de seu produto e território para gerar oportunidades de desenvolvimento regional e melhoria da qualidade de vida da comunidade.
Green purchasing: a sustainable opportunity in supermarkets in the metropolitan region of Belém
Authors: Tavares Renato Jose Caldeira , Ferreira Filho Hélio Raymundo , De Souza Fábia Maria , Ferreira Aline da Oliveira , De Aguiar Enilde Santos , Reis Ana Carolina Moraes , De Oliveira Dimitri Maurício Queiroz , Do Nascimento Leonardo Silva
Published: September 2023

Currently, there is a great concern with environmental issues in all spheres of society, including the business sector. In this context, the management of ecological purchases, known as green purchases or sustainable purchases, becomes one of the correct practices that companies must carry out so that their actions do not cause damage to the environment. Green purchases are a component of the global management of organizations and their role is to help companies become more sustainable. With the objective of evaluating whether green purchases are part of the reality of companies in the supermarket sector that operate in Belém, this study sought to identify, through the analysis of the results of the application of a structured questionnaire, the attitude of managers and suppliers of the network supermarket operator in relation to sustainability practices. The results point to managers' lack of knowledge of environmental obligations, but also indicate a great interest in developing and applying new practices that make companies more competitive and sustainable. It should be noted the difficulty in obtaining information from companies, trying to preserve their strategies and practices from competitors. It is also suggested that the sample be expanded to include other supermarket chains that did not participate in this research.
О сложности вычисления систем элементов конечных абелевых групп
Authors: Кочергин Вадим Васильевич , Kochergin Vadim Vasil'evich
Published: September 2023

Исследуется сложность реализации систем элементов конечных абелевых групп. Под сложностью реализации системы элементов над заданным базисом понимается минимальное число применений групповых операций для вычисления элементов системы по базисным элементам, при этом допускается многократное использование результатов промежуточных вычислений. Для функции Шеннона $L(n,m)$, характеризующей максимальную сложность системы из $m$ элементов, где максимум берется по всем абелевым группам порядка не более $n$, по всем их базисам и по всем реализуемым системам, установлено, что в случае выполнения условия $m = o(\log \log n)$ при $n \to \infty$ справедливо асимптотичское равенство $L(n,m) \sim \log_2 n$. Кроме того, при тех же условиях установлена асимптотика максимально возможного отличия сложности вычисления системы элементов конечной абелевой группы и сложности реализации системы одночленов, соответствующих представлениям этих элементов через базисные элементы.
Инвариантные суммы произведений дифференциалов
Authors: Малышев Фeдор Михайлович , Malyshev Fedor Mikhailovich
Published: September 2023

На основе предлагаемого способа решения так называемых $(r,s)$-систем линейных уравнений доказано, что порядки однородных инвариантных дифференциальных операторов $n$ гладких вещественных функций одной переменной принимают значения от $n$ до $\frac{n(n+1)}2$, а размерность пространства всех таких операторов не превосходит $n!$. Получена классификация инвариантных дифференциальных операторов порядка $n+s$ для $s=1,2,3,4$, а при $n=4$ - для всех порядков от 4 до 10. Однородные инвариантные дифференциальные операторы самого маленького порядка $n$ и самого большого порядка $\frac{n(n+1)}{2}$ представлены соответственно произведением $n$ первых дифференциалов $(s=0)$ и вронскианом $(s=(n-1)n/2)$. Доказано существование ненулевых однородных инвариантных дифференциальных операторов порядка $n+s$ для $s<\frac{1+\sqrt{5}}{2}(n-1)$.
Influence of dispersion on dynamics of the anti-Stokes broadening of the femtosecond pulse spectrum during filamentation in fused silica
Authors: Geints I. Y. , Zaloznaya E. D. , Dormidonov A. E. , Kandidov V. P.
Published: September 2023

Numerical simulation methods are used to study the spectral transformation of a femtosecond wave packet
during filamentation in fused silica under conditions of normal, zero, and anomalous group velocity dispersion.
It is shown that during plasma generation that causes phase modulation of the light field, a rapid anti-Stokes
broadening of the spectrum occurs. It was established that the short-wavelength shift of the broadband
supercontinuum spectrum is much larger in case of anomalous group velocity dispersion than in case of
normal and zero dispersion. The influence of the wave packet energy on the spectrum broadening dynamics
is considered. Estimates of the numerical scheme parameters are obtained based on the dispersion analysis of
the process of broadband supercontinuum propagation in a medium.
Electrophysical Properties of Methylammonium Alum Single Crystals: The Role of the Hydrogen Bond Network in the Formation of Temperature Anomalies
Authors: Gavrilova N.D. , Malyshkina I.A. , Novik O.D.
Published: September 2023

Pyroelectric, dielectric properties, and thermodepolarization currents of methylammonium alum
crystallohydrate single crystals were studied in temperature range 120–200 K. Temperature dependences
of these quantities demonstrated peaks at ∼143, ∼160, and 176.4 K (Curie point). The behavior, which is
typical to many crystals with a network of hydrogen bonds with an O–H...O distance of ∼2.7 ± 0.1 ˚A, is considered from the point of view of a quantum chemical model of a hydrogen bond network containing
water clusters in addition to individual H2O molecules. The movement of bridging protons in molecular
clusters in electric fields is coherent and correlated, and all bridging protons of the system are involved in
it. These displacements are associated with oscillations of the oxygen frame of the compression-tension type.
The discreteness of the temperature peaks of the electrophysical properties is associated with the discreteness
of the energy levels of the double-well potential, caused by the splitting of the excited levels.
Contributions of motivational components to L2 achievement through the mediation of learning strategies
Authors: Park Gi-Pyo
Published: September 2023

This study investigated the relationships among intrinsic and extrinsic motivation, learning strategies, and second/foreign language (L2) achievement. A self-report questionnaire of the Motivated Strategies for Learning Questionnaire (MSLQ) was administered to 291 university students learning English in Korea to collect data about motivation and learning strategies, and L2 achievement was determined by the grade of an English reading course. The results of data analysis using the Pearson product moment correlation and structural equation modeling (SEM) were as follows: first, the correlations among intrinsic motivation, extrinsic motivation, self-efficacy, learning strategies, and achievement were all significant, with intrinsic motivation and self-efficacy the highest and intrinsic motivation and extrinsic motivation the lowest correlations. Second, the model (Model 4) explaining the contributions of extrinsic motivation and self-efficacy to achievement mediated by learning strategies fit the current data better than other competing models (Models 1, 2, and 3). Third, significant direct effects of extrinsic motivation and learning strategies on achievement were found, whereas a significant indirect effect of self-efficacy on achievement by way of learning strategies was detected. The implications of these findings were discussed in terms of the contributions of extrinsic motivation, self-efficacy, and learning strategy use to L2 achievement, followed by future study areas to shed further light on relations among motivational components, learning strategies, and L2 achievement.
Giardiasis intestinal y su impacto en la salud pública de los pacientes en América Latina
Authors: Cevallos-Yugcha Carlos Kevin , Caldas-Zambrano Solanyi Anyeli , Cárdenas-Macias María Daniela , Fuentes-Sánchez Elisa Tatiana
Published: September 2023

La investigación realizada se fundamentó en el análisis de la giardiasis intestinal en América Latina, con el objetivo de evaluar su impacto en la salud pública de la región. Este trabajo de investigación hace referencia al proyecto de investigación titulado como “Diagnóstico de parásitos y coccidios intestinales en individuos VIH positivo de Manabí, Ecuador”, en la cual se utilizó una metodología sistemática, donde se ha seleccionado el parasito de Giardia lamblia, siendo uno de los agentes que afecta a los pacientes. Se estableció una población de referencia compuesta por 150 fuentes bibliográficas obtenidas de bases de datos como Pubmed, Springe, Elsevier, Linder, Dialnet, Scielo, entre otras. Se implicó la recopilación de datos epidemiológicos, así como la revisión de estudios clínicos y epidemiológicos. Posteriormente, se aplicaron criterios de inclusión y exclusión para seleccionar una muestra representativa de 80 fuentes que proporcionaban información sobre la giardiasis intestinal como una enfermedad parasitaria altamente prevalente en América Latina. Esta enfermedad se caracteriza por tener una amplia distribución geográfica y una elevada incidencia, especialmente entre grupos poblacionales como niños y personas con condiciones socioeconómicas desfavorables. Los síntomas gastrointestinales relacionados con la enfermedad, como la diarrea crónica, el dolor abdominal y la desnutrición, tienen un impacto significativo en la calidad de vida de los pacientes. Esto resalta la importancia de programas educativos y de concientización dirigidos a la población. En conclusión, la giardiasis intestinal representa un desafío en términos de salud pública en América Latina, con repercusiones sustanciales en la calidad de vida de quienes las personas afectadas.
MÉTODOS INOVADORES DE ENSINO: EXPLORANDO ABORDAGENS ATIVAS E APRENDIZAGEM BASEADA EM PROJETOS NA SALA DE AULA
Authors: Guimarães Junior José Carlos , Ling Bianca Patrícia Gandini , Nazaré Magno Fernando Almeida , Piazzi Larissa Cândido , Lindstron Jacqueline Andreucci , Vieira Fernando Bueno , Araujo Fabiano da Silva , De Oliveira Ivan Lucas
Published: September 2023

Este artigo tem como objetivo geral investigar os métodos inovadores de ensino, com foco nas abordagens ativas e na aprendizagem baseada em projetos, e sua aplicação na sala de aula. Para isso, será realizada uma revisão bibliográfica abrangente de estudos de caso, pesquisas e reflexões teóricas sobre o tema. A metodologia adotada consiste em uma revisão bibliográfica sistemática, com a busca de artigos, livros e publicações acadêmicas relevantes nas bases de dados científicas. Serão selecionados trabalhos que abordem a implementação das abordagens ativas e da aprendizagem baseada em projetos em diferentes contextos educacionais, bem como suas implicações no processo de ensino-aprendizagem e no desenvolvimento dos estudantes, publicados entre os anos de 2010 a 2021. Espera-se que a revisão bibliográfica forneça insights significativos sobre as melhores práticas de implementação das abordagens ativas e da aprendizagem baseada em projetos na sala de aula, bem como os benefícios e desafios enfrentados pelos educadores e alunos durante esse processo. Além disso, espera-se identificar o impacto dessas metodologias no desempenho acadêmico dos estudantes e na formação de habilidades essenciais para o século XXI, como pensamento crítico, trabalho em equipe e criatividade. Os resultados esperados dessa pesquisa contribuirão para a compreensão dos métodos inovadores de ensino como ferramentas eficazes para promover um aprendizado significativo e engajador. Isso pode auxiliar educadores e gestores na adoção de práticas pedagógicas mais dinâmicas e alinhadas com as demandas contemporâneas, buscando formar cidadãos mais preparados para enfrentar os desafios da sociedade atual, além de espera-se que este estudo inspire novas pesquisas e reflexões sobre o tema, fomentando o debate acadêmico em prol da melhoria contínua da educação.
AS PRÁTICAS ASSISTENCIAIS DESENVOLVIDAS ÀS MULHERES NO CICLO GRAVÍDICO-PUERPERAL: A MATERIALIDADE DA VIOLÊNCIA OBSTÉTRICA
Authors: De Souza Mariana Xavier , Moreira Michelle Araújo , Suto Cleuma Sueli Santos
Published: September 2023

A violência obstétrica é caracterizada por qualquer ato de violência praticado durante a assistência profissional contra a mulher no ciclo gravídico-puerperal e àquelas em situações de abortamento. Diante disso, definiram os seguintes objetivos: Descrever as práticas assistenciais desenvolvidas pelos profissionais de saúde às mulheres no ciclo gravídico-puerperal; Identificar situações de violência obstétrica durante a assistência às mulheres no ciclo gravídico-puerperal e Analisar as práticas assistenciais desenvolvidas às mulheres no ciclo gravídico-puerperal caracterizadas como violência obstétrica. Trata-se de estudo descritivo, de abordagem qualitativa, norteado pela Teoria das Representações Sociais, realizado no período de setembro de 2021 a abril de 2022, com 40 mulheres atendidas em uma maternidade de Minas Gerais, no Brasil. Os dados foram coletados através de um roteiro de entrevista semiestruturada e da técnica de associação livre de palavras e foram analisados pela técnica de conteúdo temática proposta por Bardin e pelo software IRAMUTEQ, respectivamente. Evidenciou-se práticas assistenciais obstétricas não recomendadas e sem evidência científica, muitas das quais, enraizadas no modelo tecnocrático, a exemplo do jejum prolongado na hora do parto, a ausência de contato pele a pele entre mãe e filho, o uso da manobra de Kristeller e os toques vaginais repetitivos, com enfoque para a violação dos direitos sexuais e reprodutivos, ausência de comunicação empática e cuidado respeitoso, negligência, maus-tratos, abuso de poder e intervenções sobre o corpo feminino sem o devido consentimento. Percebe-se que a violência obstétrica é um problema de saúde pública com necessidade de intervenção imediata, sendo uma delas a educação permanente para a equipe de saúde.
RISCOS RELACIONADOS AO PERFIL DE OBESIDADE EM PROFISSIONAIS DE SAÚDE NO BRASIL
Authors: Marinho Patrícia Dias Barreto , Pereira Leonardo dos Santos , Souza Elenice da Silva Marinho , Alves Marcos Marinho , Berling Raiana Soares , Batalha Elziane de Jesus Ribeiro , Marinho Eliane , Salim Karolina de Araújo Barbeiro Moura , Duarte Beatriz de Souza , Amaro Andrezza Gonçalves Vieira , De Souza Cassius
Published: September 2023

Introdução: O sobrepeso e a obesidade constituem um problema de saúde pública global, devido aos riscos para a saúde e ao aumento substancial da prevalência nos últimos anos. Objetivo: Avaliar e discutir sobre a obesidade em profissionais da saúde no Brasil Método: Revisão integrativa de artigos publicados em português, inglês e espanhol nas bases MEDLINE, COCHRANE e LILACS utilizando os descritores enfermagem, obesidade, enfermagem do trabalho, riscos ocupacionais. Foram selecionados 11 artigos. Os resultados foram avaliados quanto ao Rigor Metodológico pela Sistema Grading of Recommendations Assessment, Development, and Evaluation Resultados e discussão: A obesidade é conhecida como uma doença de complexa interação entre diversos fatores, e os eixos temáticos encontrados foram: 1-Estado Nutricional e variáveis sociodemográficas da obesidade no profissional de enfermagem, 2- Obesidade em acadêmicos que desenvolvem atividades práticas. Observou-se a prevalência de mulheres, a questão da faixa de renda mostrou-se como fator que influencia a adesão a hábitos saudáveis, a circunferência abdominal demonstrou-se como fator de risco associado a doenças crônicas não transmissíveis. Conclusão: Os cuidados com o trabalhador de enfermagem e estudos nas áreas emergem investimentos e iniciativa, especialmente no que tange a qualidade de vida, prática de exercícios e alimentação saudável.