bluuebunny/crossref_metadata_2025 huggingface dataset:
PARTICÍPIOS DUPLOS: NORMA, AVALIAÇÃO E USO ESCRITO
Authors: Miara Fernanda Lima Jardim , Coelho Izete Lehmkuhl
Published: May 2021

Esta pesquisa investiga as formas de particípio regulares e irregulares, em sentenças ativas e passivas, com base em uma análise dos verbos salvar, pegar, abrir e chegar. A amostra utilizada é formada por um corpus, extraído do jornal Diário Catarinense on-line. Os resultados deste trabalho já apontam que os particípios irregulares, além de mais bem avaliados, são as formas mais frequentes na escrita do PB (MIARA, 2013).
Implementasi Teknik Lean Manufacturing untuk Meningkatkan Produksi Joint di PT Pratamaeka Bigco Indonesia
Authors: Setiawan Fran , Lee Angelica Jesslyn Aprilia , Pramesthiwardhani Maria Vionetta , Eigia Cabrina
Published: May 2021

PT. Pratamaeka Bigco Indonesia merupakan salah satu perusahaan yang bergerak di bidang perancangan alat material handling. Perusahaan ini memproduksi sendiri komponen utama dari alat material handling berupa pipe dan joint. Permasalahan yang kerap kali terjadi adalah produksi joint tidak mencapai target produksi. Salah satu penyebab tidak tercapainya target produksi adalah waktu setup yang cukup lama. Oleh karena itu, dilakukan perbaikan dengan menggunakan metode Single Minute Exchange Dies (SMED). Usulan perbaikan yang diberikan kepada perusahaan adalah penggunaan stopper dan trolley. Selain itu, diusulkan juga untuk melakukan pergantian material ketika mesin 150T sedang beroperasi. Dalam menerapkan usulan-usulan tersebut, diperlukan perubahan layout pabrik dan implementasi 5S untuk menata tempat kerja. Dilakukan juga standarisasi proses kerja dengan menggunakan prinsip SOP dan visual display. Estimasi penurunan waktu setup dari hasil usulan perbaikan untuk mesin 150T, 110T dan 45T secara berturut-turut adalah 965 detik, 396 detik dan 216 detik. Setelah dilakukan perbaikan, target produksi belum juga dapat terpenuhi. Oleh karena itu, disarankan kepada perusahaan untuk menambah satu orang operator untuk mengoperasikan mesin.
Penerapan Metode Transformasi Ruang Warna HSI untuk Mendeteksi Tingkat Kematangan Buah Pisang Berdasarkan Fitur Warna Citra Kulit Pisang
Authors: Sakir Sakir , Rhenislawaty Rhenislawaty , Putriyana Sendri , Wibisono Supri , Sadimantara Muhammad Syukri , L Mariani , Suwarjoyowirayatno Suwarjoyowirayatno , Inthe Mita Gebriella
Published: May 2021

Pisang Lampung atau yang lebih dikenal sebagai pisang burung-burung merupakan salah satu jenis pisang yang sering dan banyak dijumpai didaerah Kendari. Penelitian ini bertujuan untuk mengetahuai tingkat kematangan buah pisang melalui pengolahan citra kulit pisang menggunakan metode transformasi ruang HSI. Pengolahan citra mempunyai peranan penting di berbagai bidang. Aplikasi pengolahan citra berkaitan dengan pemrosesan citra berkaitan dengan transformasi warna. Objek yang digunakan dalam penelitian ini yaitu citra pisang lampung atau pisang burung-burung yang diambil dengan kamera smartphone Vivo V5 Lite, dengan pengambilan gambar latar putih menggunakan kertas HVS A4 yang kemudian akan diekstrak ciri warnanya, dan dihitung tingkat kadar warna dari R (red), G (green), dan B (blue) dan diubah ke HSI. Dari hasil penelitian 30 sampel buah dimana 10 buah pisang lampung atau pisang burung-burung  mentah, 10 buah pisang lampung atau pisang burung-burung setengah matang, dan 10 buah pisang lampung atau pisang burung-burung matang, kemudian yang terdeteksi oleh citra sebanyak 13 sampel buah pisang lampung atau pisang burung-burung dimana didapatkan hasil 7 sesuai antara manual dengan aplikasi, sedangkan 6 sampel tidak sesuai.
Nodal Volume as a Prognostic Factor in Oral Tongue Cancer with Cervical Lymph Node Metastasis
Authors: Wiengnon Rattawut , rawangban worawat , Chakkabatr Chakkrapong , Tangjaturonrasme Napadon
Published: May 2021

Objectives Oral tongue cancer is the most prevalent type of oral cavity
cancer and presents the worst prognosis. With the use of tumor, lymph
node, distant metastasis (TNM) staging system, only the tumor and lymph
node size are taken into account. However, several studies have
considered the tumor volume as a possible significant prognostic factor
of oral tongue cancer with cervical lymph node metastasis. Our study,
therefore, aimed to explore the prognostic implications of the relevant
nodal volume. Design, Setting and Participants Medical records and
imaging (either from computed tomography scan, CT scan or magnetic
resonance imaging scan, MRI scan) of 70 patients diagnosed with oral
tongue cancer with cervical lymph node metastasis between January 2011
and December 2016 were retrospectively reviewed. Main outcome measures
The nodal volume was measured from the imaging using the Eclipse
application (Version 15.6.05, Varian company) and was further analyzed
for its prognostic implications, particularly on overall survival,
disease-free survival, and distant metastasis-free survival. Results
From a receiver operating characteristic (ROC) curve analysis, the
optimal cut-off value of the nodal volume was 3.95 cm3, to predict the
disease prognosis, in terms of overall survival and metastatic-free
survival (p= <0.001 and p=0.005, respectively), but not the
disease-free survival (p=0.241). For the multivariable analysis, the
nodal volume, but not TNM staging, was a significant prognostic factor
for distant metastasis (HR=4.5, 95%CI 1.1-17.94, p=0.036 vs p=0.459,
respectively). Conclusions In patients with oral tongue cancer and
cervical lymph node metastasis, the presence of a nodal volume of 3.95
cm3 was a poor prognostic factor for distant metastasis. Therefore, the
lymph node volume from the current imaging protocol may be useful in
adjunct with the current staging system to predict the disease prognosis
Crystallization Solvent Design Based on a New Quantitative Control Model of Crystal Morphology
Authors: Chai Shiyang , Li Enhui , Zhang Lei , Du Jian , Meng Qingwei
Published: May 2021

Solution crystallization is an important separation unit operation in
active pharmaceutical ingredient (API) production. Solvent is one of the
important factors affecting crystal morphology. How to select/design
suitable crystallization solvents is still one of the most urgent
problems in the crystallization field. In this paper, a framework for
crystallization solvent design based on the developed quantitative
control model of crystal morphology is proposed. First, molecular
dynamics is used to predict the crystal morphology in solvents. Next,
nine solvent descriptors are selected. Then, the quantitative
relationship between crystal aspect ratio and solvent descriptors is
developed. Subsequently, Computer-Aided Molecular Design (CAMD) method
is integrated with the developed quantitative control model. The
crystallization solvent design problem is expressed as a Mixed-Integer
Non-Linear Programming (MINLP) model, which is solved by the
decomposition algorithm. Finally, the crystallization solvent design
framework is applied to two cases: benzoic acid and ibuprofen, and
experimental verification is implemented.
Cryopreservation of Serbian autochthonous plum ‘Crvena Ranka’ using aluminium cryo-plates
Authors: Vujovic Tatjana , Jevremovic Darko , Marjanovic Tatjana , Ruzic Djurdjina
Published: May 2021

?Crvena Ranka? is one of the oldest autochthonous plum cultivars in Serbia.
However, it is endangered due to the long-term pathogen pressure and
continuous suppression by commercially important cultivars and therefore
faced with genetic erosion. This study was carried out to investigate the
suitability of two efficient and simple cryopreservation methods using
aluminium cryo-plates for its conservation. Precultured shoot tips of this
genotype were embedded in alginate gel into cryo-plates wells.
Osmoprotection was performed using loading solution with 1.9 M glycerol and
0.5 M sucrose (30 min at room temperature). In the V cryo-plate protocol,
explants were dehydrated at room temperature for 20 or 40 min with PVS A3
(37.5% glycerol, 15% dimethylsulfoxide, 15% ethylene glycol and 22.5%
sucrose) or with PVS3 (50% glycerol and 50% sucrose) for 60 min. In the D
cryo-plate protocol, desiccation for 2, 2.5 or 3 h was performed over silica
gel. Then, the cryo-plates were directly immersed into liquid nitrogen.
Unloading was done in MS medium containing 0.8 M sucrose (30 min at room
temperature). In the V cryo-plate procedure regrowth of cryopreserved
explants dehydrated with PVS A3 was between 50% and 51.9%, while in those
dehydrated with PVS3 it was 66.7%. As for the D cryo-plate method, regrowth
of cryopreserved explants ranged between 30-40%. After regrowth, shoots were
successfully multiplied and rooted. Results prove the feasibility of these
new cryogenic methods for a long-term storage of this valuable Prunus
genotype.
Matrix metalloproteinase 7 (MMP-7) and tissue inhibitor of metalloproteinases-2 (TIMP-2) downregulation complements PALG1 oncogene overexpression in pleomorphic adenoma pathogenesis
Authors: Anicic Boban , Nikolic Nadja , Carkic Jelena , Jelovac Drago , Jezdic Zoran , Dozic Branko , Danilovic Vesna , Milasin Jelena
Published: May 2021

Pleomorphic adenoma (PA) is the most common neoplasm of salivary glands and
consists of epithelial and mesenchymal components. Although a benign lesion,
it harbors a potential for recurrence and malignant transformation. Also,
due to its histological diversity and unpredictive behavior PA can represent
both diagnostic and therapeutic challenge. Matrix metalloproteinases (MMPs)
are well known modifiers of extracellular matrix (ECM) PA component and in
conjunction with their endogenous tissue inhibitors (TIMPs) may influence PA
tumor biology. PLAG1 oncogene also has an important role in PA; however,
neither the exact mechanisms of its influence nor its interactions with
other genes are completely elucidated. The aims of this study were to assess
the expression of PLAG1, MMP-2, MMP-7, MMP-9, TIMP-1 and TIMP-2 genes in
PAs, and find a possible association of gene expression levels with
clinical/epidemiological parameters of PA patients. Relative mRNA levels
were assessed using Quantitative real-time PCR analyses in 15 PAs of the
parotid gland and 5 normal salivary glands (NSGs). A statistically
significant overexpression of PLAG1 was observed in PA compared to NSG
samples (P=0.010); PA had 5.48 times higher mRNA levels than NSG. Out of the
three analyzed MMP genes, significantly lower levels of MMP-7 were found in
PA patients (P=0.026). TIMP2 was also downregulated in PA samples, compared
to NSGs (P=0.040). MMP-7 and TIMP-2 mRNA levels were decreased 2.95 and 2.85
times respectively, in PA samples. No association was found between gene
expression and clinical/epidemiological PA parameters. Our results suggest
that PLAG1 overexpression with concomitant MMP7 and TIMP2 downregulation may
contribute to PA development.
Evaluation of different growth hormones mediated callus induction and regeneration as well as the effect of colchicines, ethyl methanesulfonate (EMS) and gamma radiation on some traits of Impatiens walleriana
Authors: Sharafi Sedigheh , Azadi Pejman , Jafarkhani Kermani Maryam , Abdossi Vahid , Eskandri Ali
Published: May 2021

Impatiens is an ornamental member of family Balsaminaceae. This plant mostly
propagated by vegetative technique, which generally time wasting process. It
is often multiplicities via seed but is barricaded by F1 seed sterility. In
vitro culture of Impatiens walleriana has much significant function in fast
proliferation with useful features and elicitation of healthful and
disease-free plants. This experiment was conducted to investigate the impact
of medium and different hormones on in vitro propagation of Impatiens
walleriana by using a completely randomized design. MS medium was prepared
along with various concentrations of BAP, TDZ and ZEA. Callus was induced
and grew well in media supplemented with 0.5 mg/l NAA + 1 mg/l BAP. In order
to indirect propagation, explants were cultured in same media containing
BAP, ZEA and TDZ in combination with NAA. These treatments have ability to
organogenesis. The results revealed that the control treatment had the
lowest effect on traits including shoot percentage, number of shoots, number
of leaves, shoot length, fresh and dry weight, and it lead to maximum
proliferations in medium supplemented with 0.5 mg/l NAA + 1 mg/l BAP. The
highest root length and rooting percentage was observed in 0.5 mg/l IBA +
0.5 mg/l BAP. In addition, the effect of mutation agents was studied.
Aseptic samples were treated with ?- irradiation, Ethyl Methane Sulfonate
and colchicines at growth chamber. Treatments with 30 and 60 grey
respectively had the lower survival rate, growth rate and polyploidy while
colchicines with 0.1 and 0.2 had the highest rats. Regarding to these, the
present technique illustrate an effective system for in vitro reproduction
of Impatiens walleriana by hypocotyls cultures. In addition, colchicines
proved to be effective in induction of polyploidy in this plantlet.
Molecular identification and genetic diversity in Hypericum L.: A high value medicinal plant using RAPD markers markers
Authors: Bi Dezhong , Chen Dan , Khayatnezhad Majid , Hashjin Zohreh , Li Zifa , Ma Yuexiang
Published: May 2021

Genus Hypericum (Guttiferae, Hypericoideae) is perennial, belonging to the
Hypericaceae family, having 484 species in forms of trees, shrubs, and
herbs, distributed in 36 taxonomic sections. No detailed Random Amplified
Polymorphic DNA (RAPD) studies were conducted to study Hypericum genetic
diversity. Therefore, we collected and analyzed six species from five
provinces of Iran regions. Overall, seventy plant specimens were collected.
Our aims were 1) to assess genetic diversity among Hypericum species 2) is
there a correlation between species genetic and geographical distance? 3)
Genetic structure of populations and taxa. We showed significant differences
in quantitative morphological characters in plant species. H. dogonbadanicum
depicted unbiased expected heterozygosity (UHe) in the range of 0.10.
Shannon information was high (0.32) in H. perforaturm. H. dogonbadanicum
showed the lowest value, 0.17. The observed number of alleles (Na) ranged
from 0.22 to 0.53 in H. dogonbadanicum and H. elongaturn. Gene flow (Nm) was
relatively low (0.87) in Hypericum. The Mantel test showed correlation (r =
0.45, p=0.0001) between genetic and geographical distances. We reported high
genetic diversity, which clearly shows the Hypericum species can adapt to
changing environments since high genetic diversity is linked to species
adaptability. Present results highlighted the utility of RAPD markers and
morphometry methods to investigate genetic diversity in Hypericum species.
An Intronic Risk SNP rs12454712 for Central Obesity Acts As an Allele-Specific Enhancer To Regulate BCL2 Expression
Authors: Dong Shan-Shan , Zhu Dong-Li , Zhou Xiao-Rong , Rong Yu , Zeng Mengqi , Chen Jia-Bin , Jiang Feng , Tuo Xiao-Mei , Feng Zhihui , Yang Tie-Lin , Guo Yan
Published: May 2021

Genome-wide association studies (GWAS) have reproducibly associated the single nucleotide polymorphism (SNP) rs12454712 with waist-to-hip ratio adjusted for BMI (WHRadjBMI), but the functional role underlying this intronic variant is unknown. Integrative genomic and epigenomic analyses supported rs12454712 as a functional independent variant. We further demonstrated that rs12454712 acted as an allele-specific enhancer regulating expression of its located gene BCL2 by using dual-luciferase reporter assays and clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9. Specifically, the rs12454712-C allele can bind transcription factor ZNF329, which efficiently elevates the enhancer activity and increases BCL2 expression. Knocking down Bcl2 in 3T3-L1 cells led to the downregulation of adipogenic differentiation marker genes and increased cell apoptosis. A significant negative correlation between BCL2 expression in subcutaneous adipose tissues and obesity was observed. Our findings illustrate the molecular mechanisms behind the intronic SNP rs12454712 for central obesity, which would be a potential and promising target for developing appropriate therapies.
Infant Bladder Rhabdomyosarcoma in a Shared-Care Centre in Ghana: Case Report and Review of the Literature
Authors: Yenli Edwin M.T. , Bimpong Kingsley A , Salifu Nihad , Kwarteng Peter G. , Cheyuo Ernest K. , Fuseini Yaninga H. , Anyekase Dieu-Donnee , Akorli Emmanuel , Der Edmund
Published: May 2021

Rhabdomyosarcoma is a fairly common soft tissue sarcoma among children. Genitourinary rhabdomyosarcoma accounts for one tenth of rhabdomyosarcomas in the West African sub-region. However, its occurrence and management are yet to be reported in our resource limited study setting. Care of such patients could be a daunting task. A comprehensive paediatric oncology service should be advocated to optimize the chances of survival. A seven-month old boy was referred to our facility on account of posterior urethral valve. A week’s complaint of crying on micturition, with associated passage of scanty urine and irritability, although he was apparently well since birth with no urinary complaints. A suprapubic mass was palpated on abdominal examination. Digital rectal examination revealed a nodular pelvic mass. Open cystostomy done and histopathology showed embryonal rhabdomyosarcoma of the urinary bladder. Chemotherapy was commenced on a modified Malignant Mesenchymal Tumour protocol of the International Society of Paediatric Oncology group. The mass was reduced by a third after six cycles of chemotherapy. In resource limited settings, the management of paediatric genitourinary rhabdomyosarcoma, using multidisciplinary and multimodal approach to include the hub for comprehensive paediatric oncology services should be advocated to optimize chances of survival.
PENGEMBANGAN LAYANAN APLIKASI GO-JEK DALAM MENINGKATKAN KEPUASAN PELANGGAN
Authors: Lungsae Suhaila , Maika M. Ruslianor
Published: May 2021

Dalam penelitian ini penulis akan membahas permasalahan model bisnis berbasis ekosistem pada aplikasi Go-Jek untuk meningkatkan kepuasan dan loyalitas pelanggan. Dan pada masa terkini bahwa internet sangat mempengaruhi kehidupan masyarakat. Meningkatnya pengguna smartphone, baik Android maupun iOS, menjadikan tingkat ketergantungan masyarakat pada handphone serta internet yang tinggi. Kesempatan inilah yang mendorong para pendiri transportasi online (GO-JEK) menyediakan ojek berbasis online. Oleh karenan itu menjadi permasalahan bertujuan untuk mencari dampak ekosistem layanan dengan adanya suatu aplikasi yaitu aplikasi Go-jek. Dan juga dapat mengetahui loyalitas penggunaan aplikasi Go-jek oleh mahasiswa Universitas Muhammadiyah Sidoarjo. Metode penelitian menggunakan penelitian kualitatif pendekatan fenomenologi, bertujuan untuk mengembangkan pemahaman yang lengkap, akurat dan jelas tentang pengalaman manusia atau momen pengalaman tertentu. Dan pendekatan fenomenologi dapat mencari pengalaman pengguna secara mendalam dalam menggunakan aplikasi Go-jek. Berdasarkan hasil penelitian ini bahwa sebayak 75% informan, merasa puas terhadap layanan mitra Go-jek, meskipun mengalami kejadian tidak sesuai dengan standar prosedur operasional Go-jek, tetapi tetap puas dengan layanan yang diberikan. Go-food merupakan layanan terbanyak yang digunakan yaitu sebanyak 36 orang, layanan kedua yang paling banyak digunakan adalah Go-ride sebayak 32 orang yang menggunakannya. Tingkat loyalitas pelanggan kepada mahasiswa UMSIDA cukup tinggi dengan jumlah 52% informan dalam menggunakan aplikasi Go-jek.
Cultural Urban Catalysts as Meaning of the City
Authors: Balvočienė Vaiva , Zaleckis Kęstutis
Published: May 2021

City is a network with clear organization and architecture. It also has permanent connections. Human senses, perception and cognition are the base points while understanding these connections. Hypothesis of this article proposes that concentration of creativity potential in strategically placed junctions (cultural nodes) would catalyse people flow between them naturally. Three main features of the cultural node are distinguished, and possible identification methodology is being proposed. This strategy leads to more extensive methodology research and appliance analysing city structure.
Analisis Perubahan Sifat Karakter di Sepanjang Perjalanannya Berdasarkan Pola Kejadian dan Plot Segment dalam Film “Green Book”
Authors: Sanjaya William
Published: May 2021

Film “Green Book” merupakan film yang membahas tentang diskriminasi yang dialami oleh pekerja Italy bersama teman sekaligus atasannya yang merupakan orang Negro. Pola kejadian dalam keseluruhan cerita dapat dilihat melalui rangkaian adegan yang menggambarkan perjalanan karakter. Dalam pola kejadian tersebut, perubahan karakter dapat dilihat melalui setiap masalah dari luar (outer problem) dan masalah batin (inner problem) yang dialami. Perubahan tersebut memberikan nilai – nilai yang merefleksikan kehidupan. Penelitian ini bertujuan untuk mengetahui pola kejadian dan perubahan karakter di sepanjang perjalanan karakter dalam cerita. Metode yang digunakan dalam penelitian ini adalah kualitatif deskriptif yang mengumpulkan berbagai macam teori sebagai bahan untuk menganalisa secara akurat. Teori yang digunakan adalah teori plot segment dari David Bordwell, 7 pola kejadian dalam cerita oleh David Trottier serta perubahan sifat karakter sepanjang perjalanan oleh Christopher Vogler. Dari penjabaran yang telah dilakukan, disimpulkan bahwa terdapat 7 pola kejadian yang dapat digambarkan melalui setiap kejadian dalam cerita film. Perubahan sifat karakter terjadi sepanjang perjalanan yang dihadapi. Perubahan karakter tersebut memberi nilai yang merefleksikasn nilai – nilai kehidupan. Dalam perubahan dimensi pada aspek  sosiologi, psikologi, dan ciri – cici fisik, karakter dapat mengalami perubahan terhadap satu atau lebih dari satu aspek lain, namun karakter juga dapat mengalami perubahan pada satu aspek dalam sifatnya saja.
Karantina Wilayah sebagai Ide Penciptaan Foto Seri Tentang Topical Trends Covid-19
Authors: Setiyanto Pamungkas Wahyu , Andrea Novan Jemmi , Triyana Agus
Published: May 2021

Quarantine Areas as an Idea The Creation of A Series of Topical Trends of Covid-19. Research called quarantine areas as an idea the creation of a photograph series about topical trends covid-19 is a study based the creation of artistic, with the result of a photograph series describing the atmosphere quarantine areas due to pandemics covid-19 in Pedukuhan Pelem Sewu , RT 08 and RT 09 , Panggungharjo, Sewon, Bantul , Yogyakarta. Photo series made is activity the creation of a guide making a photograph produce a series of photos containing descriptions based on the theme or a particular subject same, that is the situation quarantine areas. Through the observation, design concept, to recording equipment, produced a series of photographs quarantine areas described the situation, the closure enter and leave in a region in which there were people infected covid-19. Methods used in this study began of observation, the design of the concept of, until shooting. The result of the creation of this series are photographs that describe scenes of residents and the activities of that lasts for quarantine areas to come into effect. Conclusions obtained from the research with the approach the work of art it produces an understanding of the circumstances and the residents habit covid-19 due to new pandemic. A new habit of them is online learning activity, aware of their health and clean environment, and of their fellow citizens for mutual support and through the quarantine.
El título de San Mateo Calpulalpan, Oaxaca. Actualidad y autenticidad de un título primordial
Authors: Romero Frizzi María de los Ángeles
Published: May 2021

Uno de los propósitos de este artículo es reflexionar sobre el uso de los Títulos Primordiales en los litigios agrarios contemporáneos. El artículo se basa principalmente en el análisis del Título de San Mateo Capulalpan (Oaxaca) y se ubica en dos tiempos: uno, cuando el título fue presentado en los Tribunales Agrarios y se solicitó un peritaje que diera constancia de su autenticidad (1996). Otro, cuando el título fue elaborado a mediados del siglo XVIII. El trabajo trata de mostrar las contradicciones que existen entre los dictámenes que solicitan los tribunales agrarios y los problemas propios del género de los Títulos Primordiales.
Asentamiento y transición en el Lienzo de San Jerónimo Otla, Coixtlahuaca
Authors: Van Doesburg Sebastián
Published: May 2021

Recientemente, se dio a conocer la existencia de un lienzo pictográfico en la comunidad de San Jerónimo Otla, una agencia de Coixtlahuaca. El documento es el decimotercer texto del llamado “Grupo Coixtlahuaca”. En esta contribución se describe el lienzo y se busca contextualizarlo con la ayuda de la documentación archivística existente y a través de la comparación con los otros documentos del mismo grupo. Se analizan varios temas relacionados con la dramática transformación de la comunidad a raíz de las reorganizaciones y redefiniciones llevadas a cabo durante el siglo XVI. La información más antigua se refiere a las relaciones entre los nobles de Otla y uno de los fundadores de Coixtlahuaca en el siglo XIII, quizás reflejando la ayuda de estos nobles en la conquista de la parte sur de la cuenca. Las datos más recientes refieren a la creación del actual pueblo en 1591 a raíz de una separación de una congregación anterior del año de 1556.
El Partido liberal Sonorense y la candidatura de Ignacio Pesqueira a la gubernatura
Authors: Trejo Zulema
Published: May 2021

El Partido liberal Sonorense y la candidatura de Ignacio Pesqueira a la gubernatura
Dos visiones en torno a un problema: las tierras comunales indígenas en Oaxaca y Michoacán, 1824-1857
Authors: Arrioja Díaz Viruell Luis Alberto
Published: May 2021

Este artículo intenta mostrar la posición que asumieron los gobiernos republicanos de Oaxaca y Michoacán frente a un componente de su realidad: las tierras comunales indígenas. En este mismo orden, trata de revelar cómo visualizaron las autoridades políticas –entre 1824 y 1857– dichas tierras, qué retórica construyeron y qué acciones legales desplegaron al respecto.
Comunidad, reformas liberales y emergencia del indígena moderno. Pueblos de la Meseta Purépecha (1869-1904)
Authors: Zárate H. J. Eduardo
Published: May 2021

El presente artículo analiza el impacto que tuvieron las reformas liberales del siglo xix en las comunidades indígenas de la Meseta Purépecha en Michoacán, no sólo en la reconfiguración de su territorio sino en la emergencia de un indígena moderno. Con base en la documentación que generaron las propias comunidades se revisan los argumentos que esgrimieron para presentarse como sujetos con derechos individuales a la vez que colectivos y negociar con el Estado mexicano la privatización de sus tierras comunales.
María del Rosario Juan Mendoza, Españoles en Xalapa. Migración e inserción en la sociedad xalapeña, 1824-1835, Zamora, El Colegio de Michoacán, 2009, 515 p.
Authors: Castillo Flores José Gabino
Published: May 2021

María del Rosario Juan Mendoza, Españoles en Xalapa. Migración e inserción en la sociedad xalapeña, 1824-1835, Zamora, El Colegio de Michoacán, 2009, 515 p.
Enrique García Hernán, Consejero de ambos mundos. Vida y obra de Juan de Solórzano Pereira (1575-1655), Madrid, Fundación Mapfre, 2007, 421 p.
Authors: Gaudin Guillaume
Published: May 2021

Enrique García Hernán, Consejero de ambos mundos. Vida y obra de Juan de Solórzano Pereira (1575-1655), Madrid, Fundación Mapfre, 2007, 421 p.
In Memoriam. María Justina Sarabia Viejo
Authors: Diego-Fernández Rafael
Published: May 2021

(Ciudad Real 1947 - Sevilla 2012)
Asentamientos caxcanes en el Cañón de Juchipila y el primer intento del Camino Real de Guadalajara a Zacatecas
Authors: Caretta M. Nicolás
Published: May 2021

En este trabajo se presentarán algunos elementos para identificar la primera ruta o camino que se quiso establecer como Camino Real que llevó a las minas de plata de Zacatecas, basado en la identificación arqueológica de sitios en el Cañón de Juchipila y la información que proporcionan las primeras fuentes que dan cuenta de las rutas usadas por los colonos conquistadores. A su vez, en este documento, se busca explorar los conflictos provocados entre los caxcanes y los españoles y sus aliados que, finalmente, culminaron con la guerra del Mixtón y lo que pasó a ser la ruta definitiva del Camino Real de Guadalajara a Zacatecas.
Regionalismo abstracto y representación simbólica de la nación en la literatura latinoamericana de la región
Authors: Schmidt-Welle Friedhelm
Published: May 2021

En Latinoamérica, la noción de “regionalismo literario” se aplica a dos corrientes literarias: la literatura de una cierta región con sus localismos, por una parte, y la llamada “novela regional” o “regionalista” que incluye la narrativa indianista e indigenista. El apogeo de esta última corresponde a las primeras tres décadas del siglo xx. En el artículo, se enfatiza el hecho de que la novela regional o regionalista, al contrario de la literatura local de una región, es una representación simbólica de la nación y, en este sentido, representa una alegoría nacional.
La utopía de fray Jacobo el Danés y su lucha por un clero indígena
Authors: Carrillo Cázares Alberto
Published: May 2021

El presente trabajo se dirige a contextualizar, dentro de la obra evangelizadora de la Iglesia mexicana del siglo xvi, el esfuerzo del franciscano danés, fray Jacobo Daciano, por defender los derechos religiosos de los indígenas a quienes, habiendo recibido el bautismo, se les negaba la recepción de los demás sacramentos, especialmente el sacerdocio, por razones raciales contrarias a la práctica de la primitiva Iglesia de los apóstoles. Este último Provincial de la Orden Seráfica en Dinamarca, expulsado de su país a raíz de la introducción del protestantismo en su patria, pasó a España y de España a México en 1542, destinado a la Custodia de su Orden en Michoacán. Su sueño evangélico quedó diseñado en una obra latina y castellana titulada Declamación del pueblo bárbaro de los indios que habiendo recibido el bautismo desea recibir los demás sacramentos, que despertó una fuerte controversia dentro de su misma Orden. Su memoria se conserva viva a través de más de cuatro siglos en los pueblos indígenas de Zacapu y de Tarecuato en Michoacán.
Sebastian Dorsch, Verfassungskultur in Michoacán (Mexiko). Ringen um Ordnung und Souveränität im Zeitalter der Atlantischen Revolutionen, Colonia, Weimar, Viena, Böhlau, 2010, 634 p.
Authors: Bock Ulrike
Published: May 2021

Sebastian Dorsch, Verfassungskultur in Michoacán (Mexiko). Ringen um Ordnung und Souveränität im Zeitalter der Atlantischen Revolutionen, Colonia, Weimar, Viena, Böhlau, 2010, 634 p.
Alfredo Pureco Ornelas, Empresarios lombardos en Michoacán. La familia Cusi entre el Porfiriato y la Posrevolución (1884-1938), Zamora, El Colegio de Michoacán, Instituto Mora, 2010, 432 p.
Authors: Lizama Silva Gladys
Published: May 2021

Alfredo Pureco Ornelas, Empresarios lombardos en Michoacán. La familia Cusi entre el Porfiriato y la Posrevolución (1884-1938), Zamora, El Colegio de Michoacán, Instituto Mora, 2010, 432 p.
Melba Falck Reyes y Héctor Palacios, El japonés que conquistó Guadalajara. La historia de Juan de Páez en la Guadalajara del siglo xvii, Guadalajara, Universidad de Guadalajara, Biblioteca Pública del Estado de Jalisco Juan José Arreola, 2009, 178 p.
Authors: Castillo Flores José Gabino
Published: May 2021

Melba Falck Reyes y Héctor Palacios, El japonés que conquistó Guadalajara. La historia de Juan de Páez en la Guadalajara del siglo xvii, Guadalajara, Universidad de Guadalajara, Biblioteca Pública del Estado de Jalisco Juan José Arreola, 2009, 178 p.
Iván Escamilla, Los intereses malentendidos. El consulado de comerciantes de México y la monarquía española, 1700-1739, México, Universidad Nacional Autónoma de México, 2011, 364 p.
Authors: Torres Puga Gabriel
Published: May 2021

Iván Escamilla, Los intereses malentendidos. El consulado de comerciantes de México y la monarquía española, 1700-1739, México, Universidad Nacional Autónoma de México, 2011, 364 p.
Antonio Escobar Ohmstede y Ana Ma. Gutiérrez Rivas, coords., Entretejiendo el mundo rural en el oriente de SLP, siglos XIX y XX, México, CIESAS, COLSAN, 2009, 356 p.
Authors: Villagómez Velázquez Yanga
Published: May 2021

Antonio Escobar Ohmstede y Ana Ma. Gutiérrez Rivas, coords., Entretejiendo el mundo rural en el oriente de SLP, siglos XIX y XX, México, CIESAS, COLSAN, 2009, 356 p.
Marcelino Cuesta Alonso, Las polémicas de Pedro Gual, Oviedo, I.M.D./S.P.A.U.A.Z., 2010, 384 p.
Authors: Connaughton Brian
Published: May 2021

Marcelino Cuesta Alonso, Las polémicas de Pedro Gual, Oviedo, I.M.D./S.P.A.U.A.Z., 2010, 384 p.
Rodolfo Suárez Molnar, Explicación histórica y tiempo social, Colección Autores, Textos y Temas. Psicología número 27, Barcelona, uam-Cuajimalpa, Anthropos editorial, 2007, 206 p.
Authors: Jiménez Marce Rogelio
Published: May 2021

Rodolfo Suárez Molnar, Explicación histórica y tiempo social, Colección Autores, Textos y Temas. Psicología número 27, Barcelona, uam-Cuajimalpa, Anthropos editorial, 2007, 206 p.
Experiencia sin lugar en el lenguaje: enunciación, autoridad y la historia de los otros
Authors: Rufer Mario
Published: May 2021

Este artículo trabaja el problema de la autoridad en los lenguajes de la historia. Tomando casos específicos de trabajo sobre políticas de memoria en Argentina y Sudáfrica y voces subalternas, se analiza de qué manera la construcción del discurso histórico-científico (el lugar de enunciación de la “fuente” histórica y el problema amplio del “archivo”) entra en tensión con prácticas poscoloniales de narrar la experiencia de la desposesión y la violencia. ¿Cómo afrontar desde la historia estos discursos de la hibridez, que no son fácilmente catalogables como testimonio, documento ni “ficción”? ¿Qué dilemas políticos enfrenta aquí el discurso histórico?
Instrumentos del poder episcopal en Indias. Cuatro seminarios tridentinos del siglo XVI
Authors: Pérez Puente Leticia
Published: May 2021

El presente trabajo tiene como propósito mostrar cómo el objetivo de los seminarios conciliares no fue tan sólo la formación del clero, sino sobre todo fortalecer a la autoridad episcopal en el gobierno de las diócesis. Fin último de la legislación tridentina que ordenó su creación. Con esa intención se estudian las circunstancias en que se crearon los seminarios de Quito en 1569, Santa Fe de Bogotá en 1582, Lima en 1591 y Guatemala en 1597.
Nikolaus Böttcher, Bernd Hausberger y Max Hering Torres, comps., El peso de la sangre. Limpios, mestizos y nobles en el mundo hispánico, México, El Colegio de México, 2011, 320 p.
Authors: Castro Gutiérrez Felipe
Published: May 2021

La sangre, ese ‘‘humor rojo contenido en las arterias y venas’’, como lo definía en sus inicios la Madre Academia, ha sido siempre asunto de fascinación, interés y, en ocasiones, temor.
Beatriz Rojas, El “municipio libre”. Una utopía perdida en el pasado. Los pueblos de Zacatecas, 1786-1835, México, Instituto Mora, Instituto Cultural de Aguascalientes, Colegio de Bachilleres del Estado de Zacatecas, 2010, 307 p.
Authors: García Ruiz Luis Juventino
Published: May 2021

Beatriz Rojas, El “municipio libre”. Una utopía perdida en el pasado. Los pueblos de Zacatecas, 1786-1835, México, Instituto Mora, Instituto Cultural de Aguascalientes, Colegio de Bachilleres del Estado de Zacatecas, 2010, 307 p.
María José Garrido Asperó, Soborno, fraude, cohecho: Los proyectos para evitar la manipulación electoral en las primeras elecciones del México independiente 1821-1822, México, Instituto Mora, 2011, 156 p.
Authors: Mujica Jaris
Published: May 2021

María José Garrido Asperó, Soborno, fraude, cohecho: Los proyectos para evitar la manipulación electoral en las primeras elecciones del México independiente 1821-1822, México, Instituto Mora, 2011, 156 p.
Infraestructura hidráulica en Guadalajara para el abastecimiento de agua potable: el caso de sustentabilidad en las galerías filtrantes de Guadalajara
Authors: Torres Rodríguez Alicia
Published: May 2021

En el presente artículo se analiza la construcción de la infraestructura hidráulica para el abastecimiento de agua a la ciudad de Guadalajara y su continuidad, específicamente, la primera obra que permitió el abastecimiento de agua de manera colectiva; las galerías filtrantes, que basan su funcionamiento en aguas phreáticas y subterráneas. A su vez se describe la región hidrológica de Guadalajara y la importancia de los actores sociales que participaron en su construcción, así como la tecnología utilizada, que hicieron posible llevar agua a la ciudad. Por otra parte, se da seguimiento, en el tiempo, de las galerías filtrantes y su impacto en las zonas de extracción, sustentabilidad y permanencia de éstas como fuente de abastecimiento para la ciudad, considerando la riqueza de sus acuíferos, los cuales han sido olvidados o no tomados en cuenta por cuestiones políticas y económicas.
Verdad y Justicia para víctimas de desaparición en México. Del fondo a la forma
Authors: Rosas Villicaña Rosa María
Published: May 2021

En este estudio se hace un análisis del fenómeno criminal de las desapariciones en México ,partiendo del sentido social de la naturaleza humana y el daño de esta forma de violencia en el tejido social, por lo que se retoma  la reflexión sobre función social del Estado para garantizar la seguridad y la paz social que se fractura ante las desapariciones. Se plantea la verdad y la justicia como derechos fundamentales y pripritarios para las víctimas y la sociedad y un camino hacia la paz, proponiendo  lineamientos y un compromiso de deber cívico y generacional en las Comisiones de la Verdad.
Juvenicidio en Córdoba (Argentina) y estrategias de biorresistencia en la acción colectiva juvenil.
Authors: Roldán Macarena
Published: May 2021

El presente artículo se propone caracterizar los procedimientos de abuso policial y de hostigamiento sistemático que afectan a jóvenes de sectores populares de Córdoba en tanto procesos de juvenicidio, tanto en su dimensión simbólica y moral como física. Asimismo, se presenta a la Marcha de la Gorra como una acción colectiva que habilita la construcción de estrategias de biorresistencia que permiten oponerse a los regímenes de opresión cotidiana, y que tienen al cuerpo de los marchantes como principal locus de realización. Ambos tópicos son abordados a partir del discurso de los propios jóvenes que participan de la Marcha. La construcción de datos se enmarca en un estudio de tipo cualitativo que empleó técnicas de registro etnográfico, observación participante, conversaciones en marcha y entrevistas en profundidad.
Christianity, Neurotheology & Cancer- Oncologic Christian Neuro Theology: New Era, Needs more attention
Authors:   New Alliance Integrative Research, Morales-Borges Raúl H
Published: May 2021

Many Christians are battling Cancer and there is a chaotic vortex of emotions that need resolving. They think they are alone. Religion and spirituality are fundamental to the human condition and play a role in our mental health and wellbeing. Initially, religion and science thrived in a complimentary relationship, only to be polarized with the aggressive secularization of science. We know that with the introduction of Neurotheology as a unique filed of scholarship and investigations that seek to understand the relationship specifically between the brain and theology, the cancer patients will feel more the Grace of God. More investigations and healthcare professionals need to be involved in this area.
FEATURES OF DIAGNOSIS AND TREATMENT OF OBSTETRIC BLEEDING, ACCOMPANIED BY COAGULOPATHY
Authors:   the Obstetrics Department, Scientific Research Institute of Obstetrics, Gynecology and Perinatology, Kamilova Markhabo , Aminzoda Nodira ,   Obstetrics Department, Scientific Research Institute of Obstetrics, Gynecology and Perinatology
Published: May 2021

The literature of recent years on modern methods of diagnosing and treating coagulation disorders in obstetric bleeding (OB) were studied and analyzed. The literature is presented on the frequency and structure of OB in the world and countries with different levels of development. It has been shown that massive OB is often accompanied by impaired blood clotting and lead to maternal mortality. In the structure of causes of maternal mortality in the world, OB is in the leading position. A theoretical and critical analysis of the literature on modern methods of diagnosing and treating coagulation disorders in OB has shown that it is necessary to continue further research on optimization of diagnostics and individual approaches in infusion-transfusion therapy of women with massive OB. Optimization of the methods of diagnosis and treatment of OB will improve obstetric outcomes in this complication. Keywords: Obstetric bleeding, maternal mortality, coagulopathy, diagnostics, treatment
ETIOLOGICAL ASPECTS OF EPISTAXIS AND ALTERNATIVE WAYS TO STOP IT
Authors:   Head of the Department of Otorhinolaryngology, Institute of Postgraduate Education in Healthcare of the Republic of Tajikistan, Shamsidinov Bobonazar , Mukhtorova Parvina ,   Department of Otorhinolaryngology, Institute of Postgraduate Education in Healthcare of the Republic of Tajikistan, Olimov Tojulo ,   Department of Otorhinolaryngology, Institute of Postgraduate Education in Healthcare of the Republic of Tajikistan, Akhrorova Zarina ,   Department of Otorhinolaryngology, Avicenna Tajik State Medical University
Published: May 2021

Objective: To study the etiology of epistaxis and to improve the mechanical ways to stop it. Methods: 354 patients with nose bleeding aged 6 months to 78 years were examined from 2,360 people who applied to the urgent ENT Department of the National Medical Center of the Republic Tajikistan, which was 15%. They conducted an otorhinolaryngological examination, evaluation of the general state, finding out the causes of nasal bleeding and all necessary measures to stop it. Results: Out of 354 patients, 339 (95.6%) provided the first emergency care in the urgent ENT Outpatient Department, and 15 (4.2%) hospitalized in ENT Department. Among general and local causes, cardiovascular disease, respiratory infections, chronic atrophic and subatrophic processes of nose mucous were identified. In 297 (83.4%) had a combination of those and other causes. The majority of patients (n=209; 58.5%) suffered from cardiovascular pathology, in particular hypertension and atherosclerosis, in 19 (5.5%) patients the nasal bleeding occurred during the period or after recently suffered acute respiratory infections. Only in 51 (14.4%) patients identified local causes of nasal bleeding, of which 15 patients were hospitalized in the ENT Department. Bleeding was stopped by the anterior nasal tamponade in 6 cases, the anterior and posterior tamponade – in 8 observations, and in one patient, with inefficiency of the posterior and anterior tamponade, ligation of external carotid artery was performed. An alternative method has been used as a rear tamponade for the first time using a device made from a conventional endotracheal tube with an inflatable cuff on the distal end. The method has proven to be more gentle and less traumatic, allowing keeping nasal breathing through the tube. This provides the best quality of postoperative management, and at times accelerates the rehabilitation process. Conclusions: The results show that the causes of nasal bleeding are most often caused by general somatic pathology and only in 14.4% of cases are associated with pathology of nasal cavity. The proposed alternative method of posterior tamponade has shown good results and the possibility of its wide practical application, especially in terms of first aid. Keywords: Epistaxis (nasal bleeding, nosebleed), posterior tamponade, endotracheal tube, hypertension, alternative method
ASSESSMENT OF COGNITIVE STATUS IN PATIENTS WITH AKINETIC-RIGID AND TREMOR-DOMINANT PARKINSON’S DISEASE
Authors:   Department of Neurology and Basics of Medical Genetics, Avicenna Tajik State Medical University, Zaripov Nurali , Ganieva Manizha ,   Department of Neurology and Basics of Medical Genetics, Avicenna Tajik State Medical University
Published: May 2021

Objective: To study cognitive changes in patients with akinetic-rigid and tremor-dominant Parkinson’s disease (PD). Methods: From January to May 2019 were examined and responded 32 patients with akinetic-rigid (n=15; 46.9%) and tremor-dominant (n=17; 53.1%) PD. The average age of the patients was 66.5±3.7 years. All patients of PD before and after receiving appropriate therapy were responded using the MMSE (Mini-Mental State Examination) scale to detect the possible cognitive dysfunctions. The study of cognitive functions in patients was conducted before the start of therapy, as well as 3 months after treatment. Results: At the admission, cognitive disorders were more significant in akinetic-rigid PD than in a tremor-dominant PD. After 3 months of appropriate therapy, cognitive dysfunction rates in patients with akinetic-rigid PD improved significantly (p<0.001) in compare to tremor-dominant PD (p<0.05). Conclusions: Using the MMSE scale helps to detect and determine the severity of cognitive changes in a timely manner and the risk of further development of dementia in patients with PD, that allows to start corrective activities in time. Timely detection and appropriate approach to the treatment of the underlying disease and the correction of cognitive impairment significantly improves the quality of life of patients themselves, contributes reducing economic costs. Keywords: Parkinson’s disease, cognitive disorders, akinetic-rigid and tremor-dominant Parkinson’s disease, MMSE scale.
CONTENT-ANALYSIS OF THE PHARMACEUTICAL MARKET OF NONSTEROIDAL ANTI-INFLAMMATORY DRUGS IN GROUPS OF ACETIC ACID DERIVATIVES IN THE KYRGYZ REPUBLIC
Authors:   Institute of Chemistry and Phytotechnology of the National Academy of Sciences of the Kyrgyz Republic, Ermekova Dinara , Ismailov Isabek ,   Department of Basic and Clinical Pharmacology, I.K. Akhunbaev Kyrgyz State Medical Academy
Published: May 2021

Objective: To segment the pharmaceutical market of non-steroidal anti-inflammatory drugs (NSAIDs) of the derivatives groups of acetic acid in the Kyrgyz Republic. Methods: The database of the State Registry of Medicines registered and approved for Medical use in Kyrgyzstan, the Department of Drugs Security and Medical Engineering of the Ministry of Health of the Kyrgyz Republic is used for analysis. Results: Analysis showed that the leaders of the pharmaceutical market in Kyrgyzstan the number of registered medicines (M) under the trade names are Medical Drugs (MD) with international generic name: diclofenac, ketorolac, indomethacin. It has been established that there are 99 trade names of NSAIDs of the groups of acetic acid derivatives in the Kyrgyz pharmaceutical market. The largest part of the range consists of diclofenac (M01AB05), represented by 62 trade names MD (62.6%), and ketorolac (M01AB15), represented by 20 trade names MD (20.2%). In the pharmaceutical market of Kyrgyzstan are NSAIDs from the groups of acetic acid derivatives from 15 countries, of which 21.1% of MDs are produced by neighboring countries, and 73.3% – in far countries. Conducted studies have revealed that the structure of the range of NSAIDs groups of acetic acid derivatives is dominated by soft medicinal forms, which making up 37.4%. A comparative analysis of the composition of MD by the number of active substances revealed that 92.9% of NSAIDs of the groups of acetic acid derivatives are monodrugs. Based on the analysis of the price segmentation of NSAIDs of the groups of acetic acid derivatives, most of the drugs are in the low-price segment. Conclusions: A sufficient assortment saturation of the pharmaceutical market of Kyrgyzstan NSAIDs groups of acetic acid derivatives has been revealed. The pharmaceutical market of the Kyrgyz Republic is dominated by monocomponent NSAIDs in the form of soft medicinal forms produced in foreign countries. Only 7 MDs from this group are in the high-price range, making the remaining drugs financially available to consumers. Keywords: NSAIDs, indomethacin, diclofenac, etodolac, ketorolac, aceclophenac.