bluuebunny/crossref_metadata_2025 huggingface dataset:
Prognostic value of baseline total metabolic tumour volume of 18F-FDG PET/CT imaging in patients with angioimmunoblastic T-cell lymphoma
Authors: Gong Huanyu , Li Tiannv , Li Jianyong , Tang Lijun , Ding Chongyang
Published: July 2021

Purpose

The aim of this study was to explore the prognostic value of baseline metabolic parameters of 18F-FDG PET/CT imaging in patients with angioimmunoblastic T-cell lymphoma (AITL).

Materials and methods

Fifty-six AITL patients (average age 64.0 ± 1.3 years) diagnosed pathologically from August 2009 to August 2019 were enrolled in this retrospective study. The total metabolic tumour volume (TMTV), total lesion glycolysis (TLG), maximum standardized uptake value (SUVmax), and correlated clinical characteristics were collected and analysed. TMTV was computed with the 41% SUVmax threshold method. The chi-square test or Fisher’s exact probability method was used to compare clinical characteristics. Kaplan–Meier curves were used to describe progression-free survival (PFS) and overall survival (OS). The log-rank test was used to analyse the difference within groups. The statistically significant factors in the univariate regression analysis were incorporated into the Cox risk proportional regression model for multivariate survival analysis.

Results

The TMTV cut-off value was 514.6 cm3 from the ROC curve analysis. Forty (71.4%) patients progressed and 31 (55.4%) patients died within a median follow-up time of 19.1 (interquartile range 7.8–34.6) months. The 1-year and 3-year PFS rates were 42.9% and 30.1%, and the 3-year and 5-year OS rates were 45.9% and 34.4%, respectively. Univariate survival analysis showed that high TMTV and TLG may be the factors contributing to poor PFS and OS. Multivariate analysis showed that TMTV and prognostic index for T-cell lymphoma (PIT) were independent parameters for PFS and OS in AITL patients. TMTV, combined with PIT, may have better risk stratification performance than TMTV alone.

Conclusions

Baseline TMTV and PIT were independent prognostic predictors in AITL patients. The combination of TMTV and PIT can facilitate prognostic stratification and contribute to personalized therapy.
YTHDF2 alleviates cardiac hypertrophy via regulating Myh7 mRNA decoy
Authors: Xu Hongfei , Wang Zhen , Chen Miao , Zhao Wenting , Tao Tingting , Ma Liang , Ni Yiming , Li Weidong
Published: July 2021

Background

Pathological cardiac hypertrophy is a major contributor of heart failure (HF), which seriously threatens human’s health world widely. Deregulation of m6A RNA methylation, and m6A methyltransferases and de-methyltransferases have been demonstrated to act essential roles in cardiac hypertrophy and HF. Here, we studied the potential roles and its underlying mechanisms of m6A Reader YTHDF proteins in HF. In this study, we constructed HF mouse model by transverse aortic constriction surgery. Primary cardiomyocytes were isolated and stimulated with isoproterenol (ISO) or phenylephrine (PHE) to induce myocardial hypertrophy.

Results

Through single-cell RNA-seq analysis, immunofluorescent staining, HE staining, Western blotting, and real time-PCR detections, we found that YTHDF2 mRNA and protein level, but not YTHDF1 or YTHDF3, was significantly increased during HF development. YTHDF2 overexpression could efficiently alleviate cardiac hypertrophy. Furthermore, through immunoprecipitation accompanied with mass spectrometry analysis, Gene Ontology (GO) analysis, and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis, we found that ISO stimulation did not evidently affect YTHDF2-interacting proteins. However, ISO or PHE stimulation significantly increased YTHDF2 protein interacting with Myh7 (beta-myosin heavy chain) mRNA, an important cardiac hypertrophy marker, in an m6A-dependent manner. Knockdown of Myh7 or deletion of the YTH domain of YTHDF2 reversed the protective effects of YTHDF2 on cardiac hypertrophy. Finally, we found that ISO or PHE stimulation promoted YTHDF2 protein expression through enhancing Ythdf2 mRNA stability in an m6A-dependent manner in cardiomyocytes.

Conclusions

Overall, our results indicate that the m6A Reader YTHDF2 suppresses cardiac hypertrophy via Myh7 mRNA decoy in an m6A-dependent manner. This study highlights the functional importance of YTHDF2-dependent cardiac m6A mRNA regulation during cardiac hypertrophy, and provides a novel mechanistic insight into the therapeutic mechanisms of YTHDF2.
A blow-up result for a system of coupled viscoelastic equations with arbitrary positive initial energy
Authors: Li Qian
Published: July 2021

This article is devoted to a study of the blow-up result for a system of coupled viscoelastic wave equations. By establishing a new auxiliary function and using the reduction to absurdity method, we obtain some sufficient conditions on initial data such that the solution blows up in finite time at arbitrarily high initial energy. This work generalizes and improves earlier results in the literature.
Assessing the relationship between the rumen microbiota and feed efficiency in Nellore steers
Authors: Lopes Déborah Romaskevis Gomes , de Souza Duarte Márcio , La Reau Alex J. , Chaves Ibrahim Zuniga , de Oliveira Mendes Tiago Antônio , Detmann Edenio , Bento Cláudia Braga Pereira , Mercadante Maria Eugênia Zerlotti , Bonilha Sarah Figueiredo Martins , Suen Garret , Mantovani Hilário Cuquetto
Published: July 2021

Background

Ruminants rely upon a complex community of microbes in their rumen to convert host-indigestible feed into nutrients. However, little is known about the association between the rumen microbiota and feed efficiency traits in Nellore (Bos indicus) cattle, a breed of major economic importance to the global beef market. Here, we compare the composition of the bacterial, archaeal and fungal communities in the rumen of Nellore steers with high and low feed efficiency (FE) phenotypes, as measured by residual feed intake (RFI).

Results

The Firmicutes to Bacteroidetes ratio was significantly higher (P < 0.05) in positive-RFI steers (p-RFI, low feed efficiency) than in negative-RFI (n-RFI, high feed efficiency) steers. The differences in bacterial composition from steers with high and low FE were mainly associated with members of the families Lachnospiraceae, Ruminococcaceae and Christensenellaceae, as well as the genus Prevotella. Archaeal community richness was lower (P < 0.05) in p-RFI than in n-RFI steers and the genus Methanobrevibacter was either increased or exclusive of p-RFI steers. The fungal genus Buwchfawromyces was more abundant in the rumen solid fraction of n-RFI steers (P < 0.05) and a highly abundant OTU belonging to the genus Piromyces was also increased in the rumen microbiota of high-efficiency steers. However, analysis of rumen fermentation variables and functional predictions indicated similar metabolic outputs for the microbiota of distinct FE groups.

Conclusions

Our results demonstrate that differences in the ruminal microbiota of high and low FE Nellore steers comprise specific taxa from the bacterial, archaeal and fungal communities. Biomarker OTUs belonging to the genus Piromyces were identified in animals showing high feed efficiency, whereas among archaea, Methanobrevibacter was associated with steers classified as p-RFI. The identification of specific RFI-associated microorganisms in Nellore steers could guide further studies targeting the isolation and functional characterization of rumen microbes potentially important for the energy-harvesting efficiency of ruminants.
Exploring cardioprotective potential of esculetin against isoproterenol induced myocardial toxicity in rats: in vivo and in vitro evidence
Authors: Pullaiah Chitikela P. , Nelson Vinod K. , Rayapu Sushma , G V Narasimha Kumar , Kedam Thyagaraju
Published: July 2021

Background

Esculetin is a natural coumarin derivative from various plants with multiple pharmacological effects. Hence, the present study was undertaken to explore the cardio protective potential of esculetin against isoproterenol induced myocardial toxicity in rats.

Methods

The treatment schedule was fixed for 28 days and the rats were divided into five groups of six each. Rats of group I received the normal saline and served as normal control, group II was received ISO (100 mg/kg body weight) for last two consecutive days of the study and served as disease control. Groups III and IV received esculetin 10 and 20 mg/kg body weight respectively once a day per oral for 28 days along with ISO for last two consecutive days of the study. Cardiac biomarkers such as CK-MB and LDH, membrane bound Na+ /K+ ATPases activity, myocardial lysosomal enzymes activity and tissue antioxidants status were estimated in the heart tissue samples. The histopathological changes in the myocardium were also assessed. Further, DPPH assay was done to evaluate the free radicals scavenging potential of esculetin. Cytoxicity assay, intracellular ROS levels by DCFDA assay and m-RNA expression of TNF-α, IL-6 and NF-κB by quantitative RT-PCR in H9c2 cell lines.

Results

The increased levels of CK-MB, LDH, LPO, myocardial lysosomal enzymes and membrane bound Na+ /K+ ATPase levels by ISO administration was significantly increased with concomitant decrease in tissue antioxidant enzymes such as GSH, Catalase, and SOD. Pre-treatment with esculetin for 28 days has significantly decreased the levels of cardiac bio-markers, lysosomal enzymes, membrane bound Na+ /K+ ATPase levels as well as Lipid peroxides which is in contrary to the ISO group. Amelioration of the antioxidant levels were also found in esculetin treated groups. Histopathological examination of heart reveals that myocardial degeneration, mononuclear cell infiltration was noticed in ISO treated rats, whereas the same was restored with esculetin treatment. In H9C2 cell lines esculetin could effectively reduced intracellular ROS inhibition and m-RNA expression of pro-inflammatory cytokines including TNF-α, IL-6 and NF-κB to prevent apoptosis or cell necrosis.

Conclusion

The study provides the evidence of cardioprotective potentials of esculetin against isoproterenol induced myocardial infarction by antioxidant and myocardial membrane stabilization along with in vitro protection from arsenic induced ROS cell necrosis or apoptosis in H9C2 cells.
Rapid automatized naming assessment in Egyptian children with attention-deficit/hyperactivity disorder
Authors: Gomaa Doaa Abd El-Hakim , Bassiouny Samia , Ghandour Hassan Hosny , ElFiky Yomna Hassan
Published: July 2021

Background

Millions of children around the whole world are diagnosed with attention-deficit/hyperactivity disorder (ADHD) which is considered as one of the most common mental disorders and often persists into adulthood. There is almost a weak point in rapid naming abilities in children with ADHD in comparison to children without ADHD.

This was a cross-sectional study that was applied on 30 patients with an age ranging from 8 to 11 years and 6 months diagnosed as ADHD based on objective and clinical examination and measures.

Results

After the application of the Rapid Automatized Naming test (RAN) test on 30 patients with ADHD, there were 24 cases out of the 30 cases (80%) below 25th percentile (at risk) and 6 cases out of the 30 cases (20%) at 25th percentile (average performance). As regard the accuracy of RAN, there were 10 cases (33.3%) below 25th percentile (at risk) and 20 cases (66.7%) at 25th percentile (average performance).

Conclusions

This study showed that among children with attention deficit hyperactivity disorder (ADHD), there was affection in Rapid Automatized Naming (RAN) duration which represents working memory affection relative to children without ADHD.
Oncologist Perspectives on Telemedicine for Patients With Cancer: A National Comprehensive Cancer Network Survey
Authors: Tevaarwerk Amye J. , Chandereng Thevaa , Osterman Travis , Arafat Waddah , Smerage Jeffrey , Polubriaginof Fernanda C. G. , Heinrichs Tricia , Sugalski Jessica , Martin Daniel B.
Published: July 2021

PURPOSE:

The use of telemedicine expanded dramatically in March 2020 following the COVID-19 pandemic. We sought to assess oncologist perspectives on telemedicine's present and future roles (both phone and video) for patients with cancer.

METHODS:

The National Comprehensive Cancer Network (NCCN) Electronic Health Record (EHR) Oncology Advisory Group formed a Workgroup to assess the state of oncology telemedicine and created a 20-question survey. NCCN EHR Oncology Advisory Group members e-mailed the survey to providers (surgical, hematology, gynecologic, medical, and radiation oncology physicians and clinicians) at their home institution.

RESULTS:

Providers (N = 1,038) from 26 institutions responded in Summer 2020. Telemedicine (phone and video) was compared with in-person visits across clinical scenarios (n = 766). For reviewing benign follow-up data, 88% reported video and 80% reported telephone were the same as or better than office visits. For establishing a personal connection with patients, 24% and 7% indicated video and telephone, respectively, were the same as or better than office visits. Ninety-three percent reported adverse outcomes attributable to telemedicine visits never or rarely occurred, whereas 6% indicated they occasionally occurred (n = 801). Respondents (n = 796) estimated 46% of postpandemic visits could be virtual, but challenges included (1) lack of patient access to technology, (2) inadequate clinical workflows to support telemedicine, and (3) insurance coverage uncertainty postpandemic.

CONCLUSION:

Telemedicine appears effective across a variety of clinical scenarios. Based on provider assessment, a substantial fraction of visits for patients with cancer could be effectively and safely conducted using telemedicine. These findings should influence regulatory and infrastructural decisions regarding telemedicine postpandemic for patients with cancer.
Bariatric Surgery for Hypothalamic Obesity in Craniopharyngioma Patients: A Retrospective, Matched Case-Control Study
Authors: van Santen Selveta S , Wolf Peter , Kremenevski Natalia , Boguszewski Cesar L , Beiglböck Hannes , Fiocco Marta , Wijnen Mark , Wallenius Ville R , van den Heuvel-Eibrink Marry M , van der Lely Aart J , Johannsson Gudmundur , Luger Anton , Krebs Michael , Buchfelder Michael , Delhanty Patric J D , Neggers Sebastian J C M M , Olsson Daniel S
Published: July 2021

Context

Craniopharyngioma is a sellar tumor associated with high rates of pituitary deficiencies (~98%) and hypothalamic obesity (~50%).

Objective

To determine the efficacy regarding long-term weight loss after bariatric surgery in obese craniopharyngioma patients with hypothalamic dysfunction.

Design

Retrospective case control study.

Setting

Multicenter international study.

Patients and participants

Obese craniopharyngioma patients (N = 16; of which 12 women) with a history of bariatric surgery [12 Roux-en-Y gastric bypass, 4 sleeve gastrectomy; median age of 21 years (range 15-52), median follow-up 5.2 years (range 2.0-11.3)] and age/sex/surgery/BMI-matched obese controls (N = 155).

Main outcome measures

Weight loss and obesity-related comorbidities up to 5 years after bariatric surgery were compared and changes in hormonal replacement therapy evaluated.

Results

Mean weight loss at 5-year follow-up was 22.0% (95% CI 16.1, 27.8) in patients versus 29.5% (28.0, 30.9) in controls (P = 0.02), which was less after Roux-en-Y gastric bypass (22.7% [16.9, 28.5] vs. 32.0% [30.4, 33.6]; P = 0.003) but at a similar level after sleeve gastrectomy (21.7% [–1.8, 45.2] vs. 21.8% [18.2, 25.5]; P = 0.96). No major changes in endocrine replacement therapy were observed after surgery. One patient died (unknown cause). One patient had long-term absorptive problems.

Conclusions

Obese patients with craniopharyngioma had a substantial mean weight loss of 22% at 5-year follow-up after bariatric surgery, independent of type of bariatric surgery procedure. Weight loss was lower than in obese controls after Roux-en-Y gastric bypass. Bariatric surgery appears effective and relatively safe in the treatment of obese craniopharyngioma patients.
Cross-species Association Between Telomere Length and Glucocorticoid Exposure
Authors: Lee Richard S , Zandi Peter P , Santos Alicia , Aulinas Anna , Carey Jenny L , Webb Susan M , McCaul Mary E , Resmini Eugenia , Wand Gary S
Published: July 2021

Context

Chronic exposure to glucocorticoids (GCs) or stress increases the risk of medical disorders, including cardiovascular and neuropsychiatric disorders. GCs contribute to accelerated aging; however, while the link between chronic GC exposure and disease onset is well established, the underpinning mechanisms are not clear.

Objective

We explored the potential nexus between GCs or stress exposure and telomere length.

Methods

In addition to rats exposed to 3 weeks of chronic stress, an iatrogenic mouse model of Cushing syndrome (CS), and a mouse neuronal cell line, we studied 32 patients with CS and age-matched controls and another cohort of 75 healthy humans.

Results

(1) Exposure to stress in rats was associated with a 54.5% (P = 0.036) reduction in telomere length in T cells. Genomic DNA (gDNA) extracted from the dentate gyrus of stressed and unstressed rats showed 43.2% reduction in telomere length (P = 0.006). (2) Mice exposed to corticosterone had a 61.4% reduction in telomere length in blood gDNA (P = 5.75 × 10-5) and 58.8% reduction in telomere length in the dentate gyrus (P = 0.002). (3) We observed a 40.8% reduction in the telomere length in patients with active CS compared to healthy controls (P = 0.006). There was a 17.8% reduction in telomere length in cured CS patients, which was not different from that of healthy controls (P = 0.08). For both cured and active CS, telomere length correlated significantly with duration of hypercortisolism (R2 = 0.22, P = 0.007). (4) There was a 27.6% reduction in telomere length between low and high tertiles in bedtime cortisol levels of healthy participants (P = 0.019).

Conclusion

Our findings demonstrate that exposure to stress and/or GCs is associated with shortened telomeres, which may be partially reversible.
The Effect of Melatonin on Incretin Hormones: Results From Experimental and Randomized Clinical Studies
Authors: Lauritzen Esben Stistrup , Støy Julie , Bæch-Laursen Cecilie , Grarup Niels , Jessen Niels , Hansen Torben , Møller Niels , Hartmann Bolette , Holst Jens Juul , Kampmann Ulla
Published: July 2021

Context

Glucose homeostasis is under circadian control through both endocrine and intracellular mechanisms, with several lines of evidence suggesting that melatonin affects glucose homeostasis.

Objective

To evaluate the acute in vivo and in situ effects of melatonin on secretion of the incretin hormones, glucagon-like-peptide 1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP), and their impact on β-cell insulin secretion.

Design

A human randomized, double-blinded, placebo-controlled crossover study combined with a confirmatory in situ study of perfused rat intestines.

Setting

Aarhus University Hospital.

Methods

Fifteen healthy male participants were examined 2 × 2 times: an oral glucose tolerance test (OGTT) was performed on day 1 and an isoglycemic IV glucose infusion replicating the blood glucose profile of the OGTT day was performed on day 2. These pairs of study days were repeated on treatment with melatonin and placebo, respectively. For the in situ study, 6 rat intestines and 4 rat pancreases were perfused arterially with perfusion buffer ± melatonin. The intestines were concomitantly perfused with glucose through the luminal compartment.

Results

In humans, melatonin treatment resulted in reduced GIP secretion compared with placebo (ANOVA P = 0.003), an effect also observed in the perfused rat intestines (ANOVA P = 0.003), in which GLP-1 secretion also was impaired by arterial melatonin infusion (ANOVA P < 0.001). Despite a decrease in GIP levels, the in vivo glucose-stimulated insulin secretion was unaffected by melatonin (P = 0.78).

Conclusion

Melatonin reduced GIP secretion during an oral glucose challenge in healthy young men but did not affect insulin secretion. Reduced GIP secretion was confirmed in an in situ model of the rat intestine.
The routes of one-eyed ants suggest a revised model of normal route following
Authors: Woodgate Joseph L. , Perl Craig , Collett Thomas S.
Published: July 2021

The prevailing account of visually controlled routes is that an ant learns views as it follows a route, while guided by other path-setting mechanisms. Once a set of route views is memorised, the insect follows the route by turning and moving forwards when the view on the retina matches a stored view. We engineered a situation in which this account cannot suffice in order to discover whether there may be additional components to the performance of routes. One-eyed wood ants were trained to navigate a short route in the laboratory, guided by a single black, vertical bar placed in the blinded visual field. Ants thus had to turn away from the route to see the bar. They often turned to look at or beyond the bar and then turned to face in the direction of the goal. Tests in which the bar was shifted to be more peripheral or more frontal than in training produced a corresponding directional change in the ants' paths, demonstrating that they were guided by the bar. Examination of the endpoints of turns towards and away from the bar indicate that ants use the bar for guidance by learning how large a turn-back is needed to face the goal. We suggest that the ants' zigzag paths are, in part, controlled by turns of a learnt amplitude and that these turns are an integral component of visually guided route following.
Associations between Hamstring Fatigue and Sprint Kinematics during a Simulated Football (Soccer) Match
Authors: WILMES ERIK , DE RUITER CORNELIS J. , BASTIAANSEN BRAM J. C. , GOEDHART EDWIN A. , BRINK MICHEL S. , VAN DER HELM FRANS C. T. , SAVELSBERGH GEERT J. P.
Published: July 2021

Purpose

Neuromuscular fatigue is considered to be important in the etiology of hamstring strain injuries in football. Fatigue is assumed to lead to decreases in hamstring contractile strength and changes in sprinting kinematics, which would increase hamstring strain injury risk. Therefore, the aim was to examine the effects of football-specific fatigue on hamstring maximal voluntary torque (MVT) and rate of torque development (RTD), in relation to alterations in sprinting kinematics.

Methods

Ten amateur football players executed a 90-min running-based football match simulation. Before and after every 15 min of simulated play, MVT and RTD of the hamstrings were obtained in addition to the performance and lower body kinematics during a 20-m maximal sprint. Linear mixed models and repeated measurement correlations were used to assess changes over time and common within participant associations between hamstring contractile properties and peak knee extension during the final part of the swing phase, peak hip flexion, peak combined knee extension and hip flexion, and peak joint angular velocities, respectively.

Results

Hamstring MVT and sprint performance were significantly reduced by 7.5% and 14.3% at the end of the football match simulation. Unexpectedly, there were no indications for reductions in RTD when MVT decrease was considered. Decreases in hamstring MVT were significantly correlated to decreases in peak knee angle (R = 0.342) and to increases in the peak combined angle (R = −0.251).

Conclusions

During a football match simulation, maximal voluntary isometric hamstring torque declines. This decline is related to greater peak knee extension and peak combined angle during sprint running, which indicates a reduced capacity of the hamstrings to decelerate the lower leg during sprint running with fatigue.
Comparative study on tertiary contacts and folding of RNase P RNAs from a psychrophilic, a mesophilic/radiation-resistant, and a thermophilic bacterium
Authors: Marszalkowski Michal , Werner Andreas , Feltens Ralph , Helmecke Dominik , Gößringer Markus , Westhof Eric , Hartmann Roland K.
Published: July 2021

In most bacterial type A RNase P RNAs (P RNAs), two major loop-helix tertiary contacts (L8–P4 and L18–P8) help to orient the two independently folding S- and C-domains for concerted recognition of precursor tRNA substrates. Here, we analyze the effects of mutations in these tertiary contacts in P RNAs from three different species: (i) the psychrophilic bacterium Pseudoalteromonas translucida (Ptr), (ii) the mesophilic radiation-resistant bacterium Deinococcus radiodurans (Dra), and (iii) the thermophilic bacterium Thermus thermophilus (Tth). We show by UV melting experiments that simultaneous disruption of these two interdomain contacts has a stabilizing effect on all three P RNAs. This can be inferred from reduced RNA unfolding at lower temperatures and a more concerted unfolding at higher temperatures. Thus, when the two domains tightly interact via the tertiary contacts, one domain facilitates structural transitions in the other. P RNA mutants with disrupted interdomain contacts showed severe kinetic defects that were most pronounced upon simultaneous disruption of the L8–P4 and L18–P8 contacts. At 37°C, the mildest effects were observed for the thermostable Tth RNA. A third interdomain contact, L9–P1, makes only a minor contribution to P RNA tertiary folding. Furthermore, D. radiodurans RNase P RNA forms an additional pseudoknot structure between the P9 and P12 of its S-domain. This interaction was found to be particularly crucial for RNase P holoenzyme activity at near-physiological Mg2+ concentrations (2 mM). We further analyzed an exceptionally stable folding trap of the G,C-rich Tth P RNA.
Bookstagram y los mercados editoriales estadounidense y portugués.
Authors: Guardado da Silva Carlos , Catanho Cláudia
Published: July 2021

El estudio, de naturaleza cualitativa, parte del análisis del volumen de ventas de libros y su evolución en los mercados de Estados Unidos y Portugal. Busca comprender de qué modo las editoriales usan la red social Instagram para promover sus títulos, cómo evalúan la comunidad literaria Bookstagram y cuál es la percepción que la comunidad tiene de su papel y reconocimiento por parte de las editoriales en la promoción del libro y la lectura. Se propone responder a la siguiente pregunta de investigación: ¿cómo puede la red social Instagram, y particularmente la comunidad literaria Bookstagram, influenciar el mercado del libro?, para lo cual se sustenta en un estudio de caso – la comunidad literaria Bookstagram –, usando las técnicas de revisión de literatura, observación directa y entrevista. Los mercados del libro en ambos países son de difícil comparación en términos de volumen, aunque también geográficos, demográficos e incluso lingüísticos. A pesar de ello, los autores concluyen que la comunidad literaria Bookstagram tiene una gran influencia en los lectores y en la promoción de hábitos de lectura, notable en las generaciones más jóvenes y, en consecuencia, en el mercado editorial. Pero la relación entre bookstragrammers y editoriales es muy distinta en los dos países: mientras que en los Estados Unidos adquiere cada vez más relevancia, en Portugal es casi inexistente.
Medios de comunicación, redes sociales y virus del miedo, durante la pandemia de COVID-19.
Authors: Moreno-Espinosa Pastora , Contreras Orozco Javier-H , Román-San-Miguel Aránzazu
Published: July 2021

Los medios de comunicación, como altavoces de la sociedad, pueden ser quienes ayuden en las situaciones de crisis a calmar a la población o a generar un clima de prudencia que puede desembocar en miedo hacia lo desconocido. En este artículo se reflexiona, a través del análisis del discurso, sobre el pensamiento único al que Marcuse (1984) denominó “el hombre unidimensional” y cómo éste sigue imperando en la sociedad actual, apreciándose de forma explícita durante la pandemia generada por la enfermedad COVID-19 provocada por un tipo, que hasta el momento era desconocido, de coronavirus. Además, se hace un paralelismo de la difusión de la pandemia en España y en México. En España el virus se ha convertido en el principal problema que es necesario erradicar mientras que en México, este virus ha venido a tapar un problema aún mayor en el país, el caso de la espiral permanente de violencia que vive. A través del análisis de las informaciones aparecidas en difrentes medios de comunicación españoles sobre la pandemia en España y México, la conclusión principal de este trabajo es que, si en España el miedo derivado del nuevo coronavirus ha sido el que ha atemorizado a la población, en el caso de México hay un virus que ataca con mayor virulencia a la población y éste es el virus de la violencia donde solo en 2019 hubo 35.000 homicidios, en 2018 fueron 34.655 y a finales de 2020 ya habían muerto asesinadas 32.759 personas.
Televisión y medioambiente: la cobertura de la Cumbre del Clima de Madrid en los informativos de Antena 3, Telecinco y TVE.
Authors: Alonso González Marián
Published: July 2021

La presente investigación analiza la cobertura informativa de la Cumbre del Clima de Madrid por las tres cadenas televisivas con mayor audiencia: Antena 3, Telecinco y TVE, a través de sus informativos de mediodía. El objetivo es determinar los aspectos formales del tratamiento informativo y comprobar si las noticias trasmitidas lo hacen desde un punto de vista pedagógico que permita concienciar sobre la necesidad de tomar medidas para paliar las consecuencias del cambio climático. Para ello hemos empleado un método de carácter mixto en el análisis de las 381 noticias emitidas entre el 31 de noviembre y el 15 de diciembre, con objeto de recoger también las informaciones previas al evento. Los resultados demuestran la importancia informativa otorgada por los informativos a las negociaciones entre los países participantes en la Cumbre, pero también a los informes relativos al medioambiente y el sostenimiento de la diversidad. También se aprecia un creciente interés de los medios por convertirse en aliados en la lucha contra el cambio climático y en ofrecer informaciones fundamentadas, cercanas en el espacio y el tiempo, y alejada de posturas catastrofistas. No obstante, por delante queda el reto de comprobar si las televisiones son capaces de mantener su atención respecto a la crisis climática o si se trata de un hecho puntual y asociado al interés informativo que genera una Cumbre mundial organizada por España.
Ensino de História: a descolonização dos currículos, a formação docente e a ênfase à memória, história e identidade dos africanos e afro-brasileiros
Authors: Sousa Cleusa Teixeira
Published: July 2021

Asações provocadas pelos movimentos sociais dos negros incitaram mudanças na sociedade brasileira, especialmente, a partir da criação do Teatro Experimental dos Negros no Rio de Janeiro (1944). Tais transformações influenciaram também o campo educacional, sobretudo, àquele relativo ao Ensino de História no ensino básico (com a introdução da cultura africana e afro-brasileira) e no universitário, dando origem a “novas” disciplinas como “História da Cultura Afro-brasileira e Indígena” e “Diversidades Culturais”. Deste modo, este artigo tem como objetivo tecer análises reflexivas sobre as mudanças no cenário do Ensino de História no Brasil, especialmente a partir da implementação das leis 10.639/2003 e 11.645/2008, que confluíram para a obrigatoriedade do ensino das diversidades étnicas, africanas, afro-brasileiras e indígenas, as quais passaram a ser contempladas  no currículo escolar e nas Diretrizes Curriculares Nacionais para a Educação das Relações Étnico-Raciais (DCNERER), tanto no ensino básico, quanto no superior. Assim, trataremos das lutas que corroboraram para a mudança da legislação, incitando o resgate da memória, história e identidade desses povos. Pois, a emergência das leis, bem como das Diretrizes Curriculares Nacionais para a Educação das Relações Étnico-Raciais, decorre das lutas dos movimentos negros, intelectuais e acadêmicos em favor do exercício da educação antirracista pautada no resgate da história da matriz africana no Brasil, propiciando o processo de descolonização dos currículos e da história e memória afro-brasileira.
Experiências e reflexões sobre a prática docente Anti/Contra/Decolonial no ensino da História na escola pública e suas relações com o Museu da Maré como uma ferramenta pedagógica da Educação Popular
Authors: Manço de Souza Francisco Overlande , Rodrigues Pereira da Silva Noélia , Salustriano da Silva Humberto
Published: July 2021

O artigo trata da experiência de prática docente decolonial em turmas do ensino médio em  escolas da rede pública do estado do Rio de Janeiro tendo como proposta pedagógica a utilização do Museu da Maré como exemplo de pedagogia Anti/Contra/Decolonial que pode ser usada em sala de aula como forma de contrapor uma historiografia tradicional eurocentrada. A experiência museológica e epistemológica do Museu da Maré nos oferece subsídios didáticos para uma historiografia alinhada aos grupos subalternizados, quando utiliza em suas práticas elementos da Educação Popular, alinhados ao da Anti/Contra/Decolonialidade.
CONTO MARAVILHOSO: UMA PROPOSTA DE ENSINO PARA A FORMAÇÃO DO LEITOR LITERÁRIO / Wonderful tale: a teaching proposal for the formation of the literary reader
Authors: Fontenele Oscarina De Castro Silva , Lima Luzimar Silva de , Santos Valdelise Pereira dos
Published: July 2021

A escola é a agência por excelência para formar leitores, no entanto não basta “mandar ler”. Para formar leitores capazes de compreender toda a força do texto literário, é necessário sistematizar o ensino de literatura; colocar no centro das práticas escolares a leitura efetiva dos textos. Nessa perspectiva, o presente artigo discute a importância e a necessidade do trabalho com textos literários na escola. Mais especificamente, traz uma sugestão de ensino de leitura literária, utilizando a metodologia de sequência didática com o gênero textual conto maravilhoso As três penas, dos Irmãos Grimm, para alunos de 6º ano do Ensino Fundamental. Desta forma, o objetivo deste artigo é apresentar um material didático, que auxilie o professor de Língua Portuguesa no processo de didatização da literatura na educação básica e, ao mesmo tempo, suscite reflexões que conduzam a uma ressignificação do trabalho de leitura do texto literário no ambiente da sala aula. Para alcançar esse objetivo, recorremos, principalmente, a autores como Candido (2004), Coelho (2003), Colomer (2003), Compagnon (2009), Cosson (2012), Jouve (2012), Todorov (2010), entre outros. Esperamos com este trabalho contribuir para ampliar o contato de professores e alunos com o texto literário, proporcionando-lhes experienciar a leitura literária e todas as descobertas dela decorrentes.
O ENSINO DO VERBO A PARTIR DO SISTEMA DE TRÊS MARCOS TEMPORAIS E DA APRENDIZAGEM ATIVA / Verb teaching based on the three time points system and the active linguistics learning
Authors: De Araujo Ana Cristina Simões
Published: July 2021

Em escolas do Ensino Fundamental e Médio, é muito comum se ter a definição de verbo como aquele que indica ação, estado ou fenômeno da natureza. Isso faz com que os alunos tenham dificuldade em compreender por que palavras como corrida, feliz ou chuva recebem outras classificações que não a de verbo. Além disso, a classificação em presente, pretérito e futuro mescla o nome da conjugação verbal com o tempo linguístico, dificultando a compreensão de enunciados em que um verbo com desinência no presente, por exemplo, assume uma ideia no passado ou no futuro. O presente artigo tem como objetivo apresentar uma proposta de ensino dessa classe gramatical a partir do sistema de três marcos temporais (REICHENBACH, 2011)[1] e dos princípios da aprendizagem ativa (PILATI, 2017). A partir de um jogo chamado “Repórter do tempo”, os alunos irão ativar seus conhecimentos inatos como falantes de língua portuguesa para interpretarem e modificarem orações com diferentes tempos verbais. Sem, a princípio, apresentar a sua nomenclatura, o professor contribuirá para que sejam percebidas, na prática, as mudanças de sentido relacionadas ao uso de um ou de outro tempo verbal. Dessa forma, será possível o estudante identificar de forma mais acertada quando se está diante de um verbo e compreender as diferentes representações temporais que uma mesma desinência pode apresentar.[1] Originalmente publicado em 1947.
UM PERCURSO POSSÍVEL PARA O CONCEITO DE ENUNCIAÇÃO / A possible route to the concept of enunciation
Authors: Costa Débora Pereira Lucas , Naedzold Simone De Sousa
Published: July 2021

O presente artigo tem como objetivo traçar um percurso histórico para a constituição do conceito de ‘enunciação’ tal como é postulado pela Semântica da Enunciação e mapear como e quando este termo aparece nos livros teóricos e sob quais características. Optou-se, através de pesquisa bibliográfica, por percorrer um trajeto teórico até o ano de 2018, partindo da década de 1660 do século XVII. O percurso é marcado pelos postulados de Antoine Arnauld, Claude Lancelot, Pierre Nicole, Gottlob Frege, Michel Bréal, Ferdinand Saussure, Pierre Guiraud, Mikhail Bakhtin, Stephen Ullmann, Émile Benveniste e chega a Oswald Ducrot e Eduardo Guimarães. Esta análise destaca Bakhtin e seu círculo, que postularam bases enunciativas a partir de Saussure e outros autores; Benveniste, que traz discussões importantes e pertinentes ao tema ora estudado; Ducrot, que estuda Saussure e Bakhtin, avançando em conceitos como locutor, alocutor, dentre outros; e Guimarães por mostrar desdobramentos importantes da teoria de Ducrot e aprofundá-la no sentido da Semântica Enunciativa. Voltamos a atenção para estes autores por entendermos que os mesmos, na contemporaneidade, são referências para o uso do termo ‘enunciação’. Compreender como uma noção teórica toma forma possibilita-nos refletir sobre a constituição da Semântica em diferentes perspectivas. Nosso corpus, formado pelas obras completas ou parciais destes autores, constitui acervo importante para a análise que empreendemos. Esta produção integra as atividades do Grupo de Pesquisa Educação e Estudos de Linguagem (GedEL/UNEMAT).
DISCURSOS SOBRE O FEMININO E O MASCULINO NA ESCOLA: UMA PROPOSTA COM PRÁTICAS DE LEITURA À LUZ DA ANÁLISE DO DISCURSO / Discourses about female and male at school: a proposal with reading practices according to the Discourse Analysis
Authors: Mota Raquel Danielli , Rodrigues Andréa
Published: July 2021

O presente artigo apresenta um projeto desenvolvido em uma turma de nono ano de uma escola da rede pública do Estado do Rio de Janeiro, com práticas de leitura voltadas para os modos de produção de sentidos sobre o feminino e o masculino em diferentes materialidades discursivas. As propostas foram pensadas a partir de observações iniciais a respeito do modo como discursos estabilizados sobre o feminino e o masculino ressoavam em algumas produções de leitura, fala e escrita por parte dos alunos. A abordagem teórico-metodológica adotada no trabalho é a da Análise do Discurso materialista (PÊCHEUX, 1969; 1975; 1983; ORLANDI, 1988; 1998), e desenvolvida no Brasil por Eni Orlandi (2003). A pesquisa contou também com teóricas feministas como Simone de Beauvoir (2016), Angela Davis (2016) e Judith Butler (1993; 2018), bem como com a contribuição de outros autores que se voltam para as questões de gênero como Pierre Bourdieu (2018). Com essas práticas, buscamos percorrer um caminho de desconstrução dos sentidos estereotipados, naturalizados, sobre o feminino e o masculino para que, então, os alunos pudessem refletir e produzir novos sentidos. Para além do envolvimento e engajamento da turma, que pode ser percebido pelas análises do processo bem como da produção escrita dos/as alunos/as, houve uma reflexão sobre a própria prática pedagógica no decorrer da pesquisa.
Terreiro e produção de epistemologias decoloniais: narrativas de um pesquisador-filho de santo
Authors: Reis Neto João Augusto Dos
Published: July 2021

Este texto é uma reflexão sobre as 'com-vivências' de um pesquisador-filho de santo em sua comunidade. O objetivo do texto é refletir sobre como o terreiro anuncia outras possibilidades de existências, conhecimentos e educações. Além disso, trato de pensar como a dupla pertença (à academia e ao terreiro) do pesquisador pode impactar na produção do conhecimento, na produção (e resgate) de outras epistemologias e na construção de uma perspectiva decolonial para a educação e a práxis de pesquisa. Para esse movimento, recorro à pesquisa (auto)biográfica e adoto os estudos descoloniais, especialmente os afro-latino-americanos como referencial teórico. Com isso, tento anunciar uma outra perspectiva de mundo, incluindo aí as políticas do conhecimento, os modos de produzir conhecimento, de ensinar e aprender.
Maíra Azevedo: uma influenciadora digital na rede ciberaxé
Authors: Conceição Lúcio André Andrade da
Published: July 2021

O artigo apresenta parte de uma pesquisa sobre a rede ciberaxé, que representa a rede de conteúdos sobre  universo religioso afro-diaspórico, que circula no ciberespaço, através de diferentes plataformas digitais. O texto estuda uma representante dessa rede, Maira Azevedo, a Tia Má, influenciadora digital com notoriedade em várias plataformas virtuais, discutindo temas relacionados ao candomblé, mulher negra, dentre outros. Para realizar este estudo foi utilizado publicações suas postadas no facebook e uma entrevista semi-estruturada feita com ela. Para suporte nas análises os conceitos de virtualidade e subjetividade são acionados em diálogo com a compreensão teórica de Exu sob duas perspectivas: uma enquanto símbolo que representa a comunicação via ciberespaço, como sendo “boca que tudo come”; a outra como fragmentos de pensamento de um coletivo e tradutor de uma compreensão de mundo fora dos cânones ocidentais.
Fabulações imagéticas e produção de outras existências negras possíveis
Authors: Mello Maíra , Soares Maria da Conceição Silva
Published: July 2021

O presente texto é parte da pesquisa guarda-chuva do grupo de pesquisa Currículos, Narrativas Audiovisuais e Diferença (CUNADI), no qual pretendemos problematizar a produção de um feminino atribuído à docência, por meio de ensaios fotográficos em que professoras se autoapresentaram, autorrepresentaram e se deram a ver a partir de questões que atravessam seus cotidianos nos espaçostempos das escolas e além delas. Neste trabalho, intersecciamos a questão racial e o racismo vivenciado por duas dessas docentes, refletindo sobre racismo e o rosto-professora por meio da produção de outras imagens possíveis sobre si, tendo a fotografia como dispositivo de pesquisa problematizador para pensarmos a invenção de si e do mundo. A partir de suas potências individuais, elas se colocaram a fabular outras imagens sobre ser mulher negra e professora para além da docência, a partir de elementos que também constituem suas existências enquanto mulher negra, como adereços de referência a religiões de matriz africana.
Síndrome de Burnout en profesores de escuelas de países latinoamericanos
Authors: Santa Cruz Flores Estela Elizabeth , Rojas Jaimes Jesús , Barboza-Palomino Miguel
Published: July 2021

En los últimos años se ha escuchado mucho sobre el síndrome de burnout conocido también como “síndrome de agotamiento profesional” SAP y cómo influye en nuestra satisfacción laboral, un porcentaje de trabajadores no se encuentra satisfecho con las actividades que realiza, ya que solo trabajan para subsistir o por necesidad.
Exámenes europeos. Unión Europea de Médicos Especialistas (UEMS). Sección de Medicina del Trabajo de la UEMS
Authors: Rodríguez-Jareño Maria Cruz
Published: July 2021

La sección de Medicina del Trabajo de la Unión Europea de Médicos Especialistas (UEMS) lleva años trabajando en la puesta en marcha del examen europeo de Medicina del Trabajo de la UEMS por considerarlo beneficioso para los residentes y los países participantes, y para la propia especialidad de Medicina del Trabajo como marca de excelencia.

La fecha fijada para el examen europeo de la especialidad es el 30 de Agosto de 2021. El examen lo puede realizar cualquier especialista en Medicina del Trabajo, pero está especialmente dirigido a residentes de último año o que han terminado recientemente la especialidad.

En la página web de la Sección de Medicina del Trabajo de la UEMS (http://www.uems-occupationalmedicine.org) se puede encontrar la bibliografía recomendada para preparar el examen, así como otra información detallada sobre  inscripción, tasas de examen y alojamiento en Bruselas, sitio donde se realiza presencialmente la prueba.
Reconocimiento de la COVID-19 como enfermedad profesional y su repercusión en diferentes colectivos profesionales
Authors: Agún Juan José , Aguilar Raúl
Published: July 2021

En la notificación nº 366 “Enfermedad de Coronavirus” publicada por el Ministerio de Sanidad en fecha 03/05/2021, con los datos individualizados notificados por las CCAA a la Red Nacional de Vigilancia Epidemiológica (al sistema SiViEs), se indica que están notificados en España 3 540 430 casos de COVID-19 de los cuales 78 293 son fallecidos. Del total de casos notificados, corresponden al personal sanitario y sociosanitario unos 80 065 (2.26%) casos de COVID-19 notificados con diagnóstico posterior al 10 de mayo de 2020, siendo significativamente mayor el porcentaje entre las mujeres (77.95% o 62 416 casos) que entre los hombres (21.95% o 17 582 casos). Además, a la cifra de 80.065 casos se deben sumar un total de 35.548 casos declarados desde el inicio de la pandemia hasta el 7/05/2020(3), obteniendo una cifra total de 115 613 casos notificados de COVID-19 en personal sanitario.
Enhancing the patient experience, one person at a time
Authors: Marsh Ellie
Published: July 2021

Ellie Marsh describes her experience of providing patient-centred care and how she discovered the true importance of this central aspect of nursing.
Radiography and ultrasound of the equine neck
Authors: Dixon Jonathon J , Meehan Lucy
Published: July 2021

Diagnostic imaging of the equine neck is undertaken for a wide variety of conditions. In many cases, radiography is the principal imaging modality, often complemented by ultrasound examination. Common conditions encountered include osteoarthritis, articular process joint osteochondral fragmentation, cervical vertebral malformation (‘wobbler’), fractures and numerous soft tissue lesions. The complex three-dimensional anatomy of the region limits interpretation of planar images and, in some cases, cross-sectional imaging (such as computed tomography) may be required. However, careful use of radiography and ultrasound can help clinicians to achieve a diagnosis in many cases, often from combining conventional and lesion-orientated projections with a thorough clinical examination.
Recovering horses after general anaesthesia
Authors: Loomes Kate , Louro Luís
Published: July 2021

The recovery phase after general anaesthesia in horses is associated with significant risk. Optimising recovery safety and improving outcomes is an active area of research in the equine veterinary literature. Several risk factors which may negatively influence recovery quality have been identified, but study results relating to treatment options have been conflicting in many cases. This review article describes the risks associated with recovery after equine anaesthesia and explores the evidence relating to physical and pharmacological options which may improve recovery quality.