bluuebunny/crossref_metadata_2025 huggingface dataset:
Learning to Learn a Cold-start Sequential Recommender
Authors: Huang Xiaowen , Sang Jitao , Yu Jian , Xu Changsheng
Published: February 2022

The cold-start recommendation is an urgent problem in contemporary online applications. It aims to provide users whose behaviors are literally sparse with as accurate recommendations as possible. Many data-driven algorithms, such as the widely used matrix factorization, underperform because of data sparseness. This work adopts the idea of meta-learning to solve the user’s cold-start recommendation problem. We propose a meta-learning-based cold-start sequential recommendation framework called metaCSR, including three main components: Diffusion Representer for learning better user/item embedding through information diffusion on the interaction graph; Sequential Recommender for capturing temporal dependencies of behavior sequences; and Meta Learner for extracting and propagating transferable knowledge of prior users and learning a good initialization for new users. metaCSR holds the ability to learn the common patterns from regular users’ behaviors and optimize the initialization so that the model can quickly adapt to new users after one or a few gradient updates to achieve optimal performance. The extensive quantitative experiments on three widely used datasets show the remarkable performance of metaCSR in dealing with the user cold-start problem. Meanwhile, a series of qualitative analysis demonstrates that the proposed metaCSR has good generalization.
Involvement of Taste Receptors in the Oro-Sensory Perception of Nutrients in Rainbow Trout (Oncorhynchus mykiss) Fed Diets with Different Fatty Acid Profiles
Authors: Roy Jérôme , Baranek Elodie , Mercier Yvan , Larroquet Laurence , Surget Anne , Ganot Akintha , Sandres Franck , Lanuque Anthony , Terrier Frederic , Briand Loic
Published: February 2022

Taste perception plays an important role in an animal’s detection of nutrients, conveying key dietary information, fundamental for its growth and survival. Because alternative terrestrial ingredients are known to affect the feeding of rainbow trout (RT, Oncorhynchus mykiss), we aimed to assess the importance of taste receptors in detection. Using self-feeders, we examined the feeding behavior (30 days of a feeding trial followed by 10 days of a preference trial) of RT fed with a commercial diet (C), vegetable diets supplemented with linseed oil (V1) or algal oil (V2). During the feeding trial those fed V2 decreased their food intake. The preference trial revealed that fish preferred V2 v. C and V1 v. V2 for fish which had consumed V1 and C during their feeding trial. Mechanistically, taste receptors were mainly expressed in taste organs and regulated by diet, which indicated the function of the taste receptors. Some taste receptors for fatty acids (such as the ffar receptor) and amino acids (such as the tasr receptor) were highly expressed in the RT tongue. While ffar2a transcripts were upregulated by vegetal diets in the tongue, ffar1 and ffar4, known for important roles in mammals, were very low expressed and not found in the RT genome, respectively. Overall findings show that RT displayed the fundamental mechanisms for oro-gustatory perception of nutrients related to different diet composition.
Discrete Optimization on Truck‐Drone Collaborative Transportation System for Delivering Medical Resources
Authors: Lin Min , Chen Yuming , Han Rui , Chen Yao
Published: February 2022

Under the epidemic, closed management has turned a large number of communities into lonely islands, and the contactless delivery method of UAV has become the rigid demand in this special period. This paper studies a collaborative system of multi‐UAV multitruck transportation, which can deliver emergency materials such as medicine to remote areas or closed communities. In this system, delivery tasks are assigned to multiple trucks and multiple drones on each truck can perform delivery tasks in parallel, thereby improving delivery efficiency. We study the routing problem of this system specifically for medical supplying road network and establish mixed‐integer model and hybrid algorithm. We show by experiments that the number of trucks has more significant impact on the optimal solution than the number of drones and the performance of hybrid particle swarm optimization is better than the performance of the other algorithms.
Design of a Fixed-Wing UAV Controller Combined Fuzzy Adaptive Method and Sliding Mode Control
Authors: Guo Yufei , Luo Leru , Bao Changchun
Published: February 2022

To overcome the complexity of the coupled nonlinear model of a fixed-wing UAV system and the uncertainty caused by a large number of interference factors, a control algorithm combining fuzzy adaptive control and sliding mode variable structure control was proposed. The controller algorithm mainly relies on the sliding mode variable structure control method to solve the control problem of the strongly coupled complex nonlinear system. Based on sliding mode control, a fuzzy adaptive method is introduced to reduce the chattering problem of the traditional sliding mode control, and the uncertain parameters and unknown functions caused by external disturbances are approximated by this method. In this study, two types of fuzzy adaptive sliding mode controller were designed according to the different object ranges of the fuzzy adaptive algorithm. In addition, the stability of the controllers was verified using the Lyapunov method. Finally, numerical simulations are performed to demonstrate the effectiveness of the proposed controllers by comparing with the traditional sliding mode controller.
Air-Liquid Exchange by Free Hand and One Needle for Unhealed Macular Hole
Authors: Lin Haishuang , Ji Yiting , Xia Luqi , Lin Bo , Li Zhihua , Hu Zhixiang , Wu Ronghan
Published: February 2022

Aim. To report the treatment of 7 cases of unsealed hole after macular hole surgery with air-fluid exchange. Methods. Retrospective case series. We collected 7 eyes of 7 patients with unsealed hole an unsealed hole about 2 weeks after macular hole surgery (23G vitrectomy with internal limiting membrane peeling with sterilizing air tamponade) in our hospital from February 2018 to December 2018. All patients underwent “air-liquid exchange by free hand and one needle.” The prone position was taken one week after operation. The macular holes before and after operation were examined by frequency-domain optical coherence tomography (SD-OCT). Results. The size of the macular hole before vitrectomy was 481 ± 156 μm (range: 281–609 μm). Two weeks after vitrectomy (before air and liquid exchange), the size of the macular hole was 295 ± 92 μm (range: 210–421 μm). All macular holes were closed within 7–14 days after air-liquid exchange. There was no complaint of discomfort among these patients. Conclusion. From this preliminary study, air-liquid exchange by free hand and one needle seems to be safe and effective in the treatment for patients with unsealed and tiny macular hole after vitrectomy as the lack of long effective gas in China. However, the exact efficacy and safety need further large case studies.
English Research Learning and Functional Research Based on Constructivism Theory and Few-Shot Learning
Authors: Li Chengyun
Published: February 2022

Research-based learning is a comprehensive practical course that requires students to identify research topics from their study life and social life and acquires knowledge and applied knowledge through independent inquiry in a way similar to scientific research. Under the framework of CT (constructivism theory), through the study of English research-based learning and its functions, starting from few-shot learning, a college English teaching model based on the integration of network and research-based learning is constructed to explore the realization method of this model in the teaching process. UCSR-EW (user context-aware semantic-aware recommendation for English words) algorithm is used to generate English word recommendation, and the English word records are represented by the semantic model. Then, the acceptance of English words is measured according to the learning stage and English word records, and then, the similar users are matched, and finally, the intelligent recommendation of English words is realized. CC (confidence coefficient) is introduced into the pronunciation error correction algorithm to improve the traditional pronunciation error correction algorithm, so as to improve the error correction effect.
Effects of Dietary Bitter Melon Extract on Growth Performance, Antioxidant Capacity, Inflammatory Cytokines Expression, and Intestinal Microbiota in Common Carp (Cyprinus carpio L.)
Authors: Qin Chaobin , Wang Junli , Zhao Wenli , Pi Daming , Yan Xiao , Nie Guoxing
Published: February 2022

Bitter melon extract (BME), which contains a variety of natural bioactive substances, has diversified biological functions. The present study is aimed at evaluating the effects of dietary supplementation of BME on growth performance, antioxidant capacity, inflammatory cytokine expression, and intestinal microbiota in common carp (Cyprinus carpio L.). An 8-week feeding trial was conducted using four isonitrogenous and isoenergetic diets containing different levels of BME (0%, 0.25%, 0.5%, and 1% for control, LBME, MBME, and HBME groups, respectively). The results showed that there were no significant differences in the growth performance of common carp among all groups, including final body weight (FBW), weight gain rate (WGR), specific growth rate (SGR), feed conversion ratio (FCR), and viscera index (VSI) (

p
>
0.05

), but the condition factor (CF) was decreased by all BME treatments (

p
<
0.05

). Serum superoxide dismutase (SOD) activity was significantly improved in all BME groups (

p
<
0.05

), and serum catalase (CAT) activity was significantly higher in the MBME group (

p
<
0.05

). Serum malondialdehyde (MDA) level was lowest while serum total antioxidant capacity (T-AOC) was highest in the HBME group (

p
<
0.05

). Dietary BME supplementation inhibited proinflammatory cytokine (il-1β and il-8) mRNA expression, while anti-inflammatory cytokine (il-6 and il-10) mRNA expressions were promoted (

p
<
0.05

). Furthermore, principal coordinate analysis (PCoA) showed that there were no differences in bacterial communities among different groups, and Shannon index and Simpson index of intestinal microbiota were unaffected (

p
>
0.05

). Whereas dietary BME reduced Firmicutes abundance and the ratio of Firmicutes to Bacteroidetes at phylum level, the relative abundance of streptococcaceae at family level, Streptococcus and Exiguobacterium at genus level were also decreased (

p
<
0.05

). Overall, these results suggested that dietary supplementation of BME improved serum antioxidant capacity, anti-inflammatory activity, and modified intestinal microbiota in common carp.
Anlotinib Enhances the Antitumor Activity of High-Dose Irradiation Combined with Anti-PD-L1 by Potentiating the Tumor Immune Microenvironment in Murine Lung Cancer
Authors: Yuan Meng , Zhai Yirui , Men Yu , Zhao Maoyuan , Sun Xin , Ma Zeliang , Bao Yongxing , Yang Xu , Sun Shuang , Liu Yunsong , Zhang Wanting , Hui Zhouguang
Published: February 2022

Background. Radioimmunotherapy has become one of the most promising strategies for cancer treatment. Preclinical and clinical studies have demonstrated that antiangiogenic therapy can improve the efficacy of immunotherapy and sensitize radiotherapy through a variety of mechanisms. However, it is undefined whether angiogenesis inhibitors can enhance the effect of radioimmunotherapy. In this study, we aim to explore the role of anlotinib (AL3818) on the combination of radiotherapy and immune checkpoint inhibitors in Lewis lung carcinoma mouse. Methods. C57BL/6 mouse subcutaneous tumor model was used to evaluate the ability of different treatment regimens in tumor growth control. Immune response and immunophenotyping including the quantification and activation were determined by flow cytometry, multiplex immunofluorescence, and multiplex immunoassay. Results. Triple therapy (radiotherapy combined with anti-PD-L1 and anlotinib) increased tumor-infiltrating lymphocytes and reversed the immunosuppressive effect of radiation on the tumor microenvironment in mouse model. Compared with radioimmunotherapy, the addition of anlotinib also boosted the infiltration of CD8+ T cells and M1 cells and caused a decrease in the number of MDSCs and M2 cells in mice. The levels of IFN-gamma and IL-18 were the highest in the triple therapy group, while the levels of IL-23, IL-13, IL-1 beta, IL-2, IL-6, IL-10, and Arg-1 were significantly reduced. NF-κB, MAPK, and AKT pathways were downregulated in triple therapy compared with radioimmunotherapy. Thus, the tumor immune microenvironment was significantly improved. As a consequence, triple therapy displayed greater benefit in antitumor efficacy. Conclusion. Our findings indicate that anlotinib might be a potential synergistic treatment for radioimmunotherapy to achieve better antitumor efficacy in NSCLC patients by potentiating the tumor immune microenvironment.
Signal Recognition of Polyphase-Coded Radar Signals Based on Multifeature Fusion
Authors: Wang Xiaofeng , Dong Huixu , Tian Ruilan
Published: February 2022

For improving recognition accuracy of polyphase-coded radar signals under low signal to noise ratio (SNR), a recognition method based on multifeature and feature selection was proposed. First, feature parameters of polyphase-coded radar signals in time domain, frequency domain, and pseudo-Zernike moments of Choi-Williams distribution (CWD) were extracted, respectively. And then, redundancy features and small-correlation features were removed based on mutual information with greedy idea. Finally, recognition of polyphase-coded radar signals was implemented using support vector machines (SVM). The experimental results showed that the average recognition accuracy of proposed method was over 90% when SNR is 0 dB, and the recognition performance was superior to the existing methods.
Role of P2X4/NLRP3 Pathway-Mediated Neuroinflammation in Perioperative Neurocognitive Disorders
Authors: Yuan Hui , Lu Bo , Ji Yiqin , Meng Bo , Wang Ruichun , Sun Daofan , Liu Rongjun , Zhai Xiaojie , Li Xiaoyu , Qin Jinling , Chen Junping
Published: February 2022

Several studies have demonstrated that neuroinflammation is the key to perioperative neurocognitive disorders (PND); however, the specific mechanism postsurgery and anesthesia has not yet been fully clarified. The present study is aimed at exploring the effects of P2X4/NLRP3 signaling pathway in neuroinflammation and cognitive impairment after surgery. 12–14-month-old male C57BL/6 mice undergoing open tibial fracture surgery by sevoflurane anesthesia were administered P2X4R inhibitor 5-BDBD or saline was intraperitoneally for 3 consecutive days after surgery. Then, the animals were subjected to Morris water maze test or sacrificed to collect the hippocampus. The level of P2X4R and NLRP3 was estimated by Western blot, the activation of microglia was detected via immunohistochemistry, and the expression of TNF-α, IL-1β, and IL-6 was quantified by enzyme-linked immunosorbent assay. These results indicated that tibial surgery caused cognitive impairment, increased the expression of P2X4R and NLRP3, and aggravated the neuroinflammation and microglia activation. However, intraperitoneal injection of 5-BDBD attenuated these effects. In conclusion, these findings indicated that the P2X4/NLRP3 pathway might be involved in the pathophysiology of PND.
Prediction of Insulin Resistance and Impaired Fasting Glucose Based on Sex Hormone-Binding Globulin (SHBG) Levels in Polycystic Ovary Syndrome
Authors: Biernacka-Bartnik Aleksandra , Kocełak Piotr , Owczarek Aleksander Jerzy , Choręza Piotr , Puzianowska-Kuźnicka Monika , Markuszewski Leszek , Madej Paweł , Chudek Jerzy , Olszanecka-Glinianowicz Magdalena
Published: February 2022

Objective. Decreased synthesis of sex hormone-binding globulin (SHBG) related to hyperinsulinemia is one of the disturbances characteristic of polycystic ovary syndrome (PCOS). Hyperinsulinemia is a compensatory mechanism for liver insulin resistance (IR); thus, SHBG may be considered as a surrogate marker of liver IR. Therefore, this study aimed to assess the prediction of IR and impaired fasting glucose (IFG) based on SHBG levels in women with PCOS. Methods. This analysis included data retrieved from medical records of 854 patients with PCOS hospitalized in the Gynecological Endocrinology Clinic from 2012 to 2019. Data including anthropometric parameters, fasting plasma glucose, insulin, and SHBG levels were analyzed. BMI and HOMA-IR were calculated with standard formulas. Results. IFG and IR assessed based on HOMA-IR values > 2.0 were found in 19.5% and 47.8% of the study group, respectively. Empirical optimal cutoff values for SHBG levels were ≤41.5 nmol/L typical for IR (AUC 0.711, sensitivity 61.1%, specificity 71.6%, positive predictive value (PPV) 70.7%, and negative predictive value (NPV) 62.1%). The probability of insulin resistance occurrence for SHBG concentration 26.1 nmol/L (the lower normal range) was 61.6% (95% CI: 57.4%–65.8%). The SHBG concentration of 36.4 nmol/L and 8.1 nmol/L was related to a 10% and 20% probability of IFG, respectively. Conclusion. In conclusion, this is the first study estimating the probability of liver IR and IFG occurrence based on SHBG levels in women with PCOS. Despite the low sensitivity, SHBG level below 42 nmol/L should cause closer monitoring for the fatty liver and prediabetes.
Changes in Anterior Chamber Parameters Measured by Pentacam in Coronavirus Disease 2019 Infection: A Longitudinal Study
Authors: Shokoohi-Rad Saeed , Abrishami Mojtaba , Bakhtiari Elham , Payandeh Asma , Heidarzadeh Hamid-Reza
Published: February 2022

Purpose. To evaluate changes in anterior segment parameters measured by imaging in coronavirus disease 2019 (COVID-19) infection. Methods. This longitudinal observational study included patients who recovered from COVID-19. All subjects exhibited a confirmed diagnosis of COVID-19 with a positive result of nasopharyngeal reverse transcription-polymerase chain reaction evaluation. Corneal Pentacam (Oculus, Dutenhofen, Germany) imaging was performed at least two weeks after recovery from systemic COVID-19. Measurements were repeated one and three months later. Results. A total of 20 patients, 11 (55%) of whom were females, with a mean age of 35.5 ± 7.1 years (age range: 25–51 years) recovered from nonhospitalized COVID-19 infection, were enrolled in this study. An increase in the keratometry mean front, keratometry mean back, cornea volume, and anterior chamber depth was observed in the longitudinal evaluation; however, they showed no statistical significance. The anterior chamber volume was statistically increased at three-month follow-up, compared to baseline (baseline: 177.8 ± 36.68 mm3; three months: 182.25 ± 39.58 mm3,

P
=
0.048

). Conclusion. COVID-19 infection may affect the cornea and anterior segment.
Contemplated Investigation and Statistical Prediction of the Swelling Potential of Expansive Soils Using Index Properties of Holte Town, Southern Ethiopia
Authors: Entonyos Tilahun K. , Dasho Defaru K. , Pampana Vasudeva R.
Published: February 2022

Expansive soils are problematic by exhibitingl shrink‐swell behaviors and high plasticity under different moisture conditions, which is communal in salient areas of Ethiopia. This article aims to conduct a contemplated investigation and statistical analysis‐based prediction for swelling potentials of soils using the index properties. This is used to define the properties of soils by investigation and to minimize the rigorous futuristic investigation by providing the prediction model of soils of the Holte town. Hence, thirty soil samples were collected from fifteen test pits with a depth of 1.5 m to 3.0 m from various locations. Investigations were conducted in the field and laboratory. Results revealed that the in situ moisture content, dry density, and bulk unit weight ranges were found, 31.21–40.93%, 1.20–1.30 g/cm3, and 1.60–1.73 g/cm3, respectively. The soil grain results presented that the study area is dominantly fine‐grained soil properties (i.e., silt and clay). Liquid limit, plastic limit, plasticity index, and liquidity index ranged from 58 to 77%, 26–33%, 28–45%, and 0.00–0.35%, respectively, which assured that the soils in this town have 87% high plastic clay (CH). In addition, the swelling potential, swelling pressure, free swell, and activity investigations revealed that the soils in this town are highly plastic with a high degree of expansiveness. This was found that the swelling potential is the main measuring property of expansive soils, which was predicted by the statistical tool SPSS using numerous index properties. After conducting numerous statistical models, the best swelling potential was found Sp = 6.876γd + 0.178PI − 10.664, which is maintained by 90% of the points found within the regression line having a mean confidence level of 99.99%. In conclusion, the obtained model was validated and was found as an optimal measuring tool of expansiveness through the swelling potential of soils specifically in Holte town.
An Overview of Pavement Degradation Prediction Models
Authors: Shtayat Amir , Moridpour Sara , Best Berthold , Rumi Shahriar
Published: February 2022

Pavement management systems (PMSs) have a primary role in determining pavement condition monitoring and maintenance strategies. Moreover, many researchers have focused on pavement condition evaluation tools, starting with data collection, followed by processing, analyzing, and ultimately reaching practical conclusions regarding pavement condition. The analysis step is considered an essential part of the pavement condition evaluation process, as it focuses on the tools used to find the most accurate results. On the other hand, prediction models are important tools used in pavement condition evaluation to determine the current and future performance of the road pavement. Therefore, pavement condition prediction has an effective and significant role in identifying the appropriate maintenance techniques and treatment processes. Moreover, pavement performance indices are commonly used as key indicators to describe the condition of pavement surfaces and the level of pavement degradation. This paper systematically summarizes the existing performance prediction models conducted to predict the condition of asphalt pavement degradation using pavement condition indexes (PCI) and the international roughness index (IRI). These performance indices are commonly used in pavement monitoring to accurately evaluate the health status of pavement. The paper also identifies and summarizes the most influencing parameters in road pavement condition prediction models and presents the strength and weaknesses of each prediction model. The findings show that most previous studies preferred machine learning approaches and artificial neural networks forecasting and estimating the road pavement conditions because of their ability to deal with massive data, their higher accuracy, and them being worthwhile in solving time-series problems.
Construction of Neonatal PICC Nursing Quality Evaluation System
Authors: Xiaoli Shi , Weiyan Hao , Li Dandan
Published: February 2022

Objective. In order to improve the quality of neonatal care, this study analyzed the construction of PICC and scientifically evaluated the quality of PICC. Methods. A total of 100 neonatal patients admitted to the Pediatric Medical Intensive Care Unit of the People’s Hospital in Laizhou City of Shandong Province between January 2015 and December 2018 were selected for nursing intervention. They were randomly divided into 50 cases in the observation group and 50 cases in the reference group. In the observation group, 50 were neonatal patients who received and completed PICC catheterization care, and in the reference group, 50 were neonatal patients with traditional conventional puncture care, PICC nursing quality evaluation index system, and nursing quality standard were applied, and questionnaire survey and patient satisfaction survey were conducted in the treatment. The two groups were compared for the success rate of one puncture, catheter detachment, treatment of local bleeding, incidence of nursing risk during other treatment, and other related nursing quality results. Results. The incidence of related medical and nursing risks in neonatal patients such as one-time puncture success rate, catheter detachment during treatment, and local bleeding was significantly lower than those in neonatal patients receiving conventional nursing methods. The incidence of nursing risk events during puncture was effectively reduced. It is shown in the comparison of adverse events in neonatal pediatric nursing in the fourth quarter of 2017 and 2018. In 2018, the proportion of adverse events in neonatal nursing is decreasing, the quality index of nursing is improving, and the satisfaction of patients’ families and relevant personnel in treatment is increasing. Conclusion. The construction and application of neonatal PICC nursing quality evaluation system can improve the success rate of one-time puncture, reduce the pain of newborns, improve the nursing quality evaluation system, scientifically and reasonably provide effective methods and basis for hospital PICC nursing, and play an important role in the development of pediatric nursing.
Experimental Study of the Flow Mechanism of Deep Lacustrine Carbonate Reservoirs in the Yingxi Area of the Qaidam Basin
Authors: Luo Xiangrong , Zheng Yongxian , Huang Penggang , Yang Li’an , Chen Xiaodong , Ren Xiaojuan , Wang Guo , Wang Yanzhi , Wang Zhiguo , Li Xiaoxiao
Published: February 2022

Many of the exploration and development theories derived for conventional clastic rock reservoirs are not applicable to pore-fracture lacustrine carbonate reservoirs. The fluid flow mechanisms under reservoir conditions are still unclear. Therefore, in this study, the rock samples were characterized using X-ray diffraction (XRD), porosity-permeability analysis, scanning electron microscopy (SEM), plain thin sections, and casting thin sections. The core samples were classified into two types (fractures and matrix pores) based on their reservoir spaces. The core flow experiments were performed under reservoir conditions using reservoir core plugs. The experimental results demonstrate that the cores, especially the fractured cores, have a strong stress sensitivity. The oil phase flow in the core has the characteristics of non-Darcy flow, and the threshold pressure gradient is 0.01–0.003 MPa/m. Additionally, for the oil-water two-phase flow in the fractured core, the water phase relative permeability of the residual oil is high. In contrast, the water phase relative permeability of the matrix core is less than 0.2. The nuclear magnetic resonance (NMR) transverse relaxation time (

T

2

) spectra were used to analyze the differences between the water flooding characteristics of the two pore structures. The experimental results show that the peaks of the

T

2

spectra after water flooding are lower than those before water flooding, and the matrix cores have a better oil displacement effect. The relaxation time of 0.1–10 ms makes the greatest contribution to the water flooding efficiency. The micropores smaller than 10 μm in diameter play an important role in the water flooding of the matrix core. These results will provide theoretical basis for solving the difficult problems of developing deep lacustrine carbonate reservoirs.
Anti-SARS-CoV-2 Antibody Screening in Healthcare Workers and Its Correlation with Clinical Presentation in Tertiary Care Hospital, Kathmandu, Nepal, from November 2020 to January 2021
Authors: Aryal Suraj , Pandit Sanskriti , Pokhrel Sushant , Chhusyabaga Mandira , Bista Pabitra , Bhatt Mahendra Psd. , Subedi Dharma Datta , Rijal Basista Psd.
Published: February 2022

Background. Antibody titer and the life span of antibodies against SARS-CoV-2 have been found to be associated with the clinical presentation in individuals. The extent of exposure of healthcare workers and the general public to SARS-CoV-2 needs to be assessed to monitor the COVID-19 pandemic. Thus, this study is an attempt in assessing the anti-SARS-CoV-2 antibody in health care workers. Methods. This laboratory-based cross-sectional study was performed in Manmohan Memorial Medical College and Teaching Hospital, Kathmandu from November 2020 to January 2021. A total of 185 HCWs were enrolled in this study. Their serum samples were screened for anti-SARS-CoV-2 antibodies, and a structured questionnaire was administered to collect further information. Anti-SARS-CoV-2 antibody screening was performed using lateral flow immunoassay. The data were analyzed using SPSS version 20. Results. Among 185 HCWs that participated in the study, 41 (22.2%) tested positive for the anti-SARS-CoV-2 antibody. Of these 41 HCWs, 37 tested positive for IgG only and 4 of them tested positive for both IgM and IgG antibodies. The presence of the previous history of SARS-CoV-2 infection (

p
<
0.001

), the presence of flu-like symptoms within the last 6 months (

p
<
0.001

), and the presence of positive contact history (

p
=
0.002

) were statistically significant with the presence of the antibody among HCWs. Conclusion. Healthcare workers carry a high burden of SARS-CoV-2 infection and are at risk of acquiring infection from their workplace. Anti-SARS-CoV-2 antibody screening among healthcare workers is highly recommended in multiple healthcare settings as it can help in monitoring transmission dynamics and evaluation of infection control policies.
C-Lock: Local Network Resilient Port Knocking System Based on TOTP
Authors: Junquera-Sánchez Javier , Cilleruelo Carlos , de-Marcos Luis , Martinez-Herráiz José-Javier
Published: February 2022

Port knocking is an access-control technique that consists of revealing a network protected resource only to those users that can prove they know a preshared port sequence. This proving process is done by connecting to the defined ports in the correct order; so, the list gets exposed to the adversaries with access to the connection’s channel. We propose a newfangled technique for protecting this process, avoiding eavesdroppers to get a long-live valid sequence. Our method is based on TOTP codes and has been designed thinking on making it the most usable as possible. There has been designed two different approaches, but we demonstrate that the most simple of them is far enough robust, while it remains to be very usable. This technique is especially suitable for enhancing the resilience of network services against local network adversaries.
Dietary Strategies for Better Utilization of Aquafeeds in Tilapia Farming
Authors: Gule Thandile T. , Geremew Akewake
Published: February 2022

Feed management practices significantly impact the production performance of tilapia (Oreochromis species) culture economically; hence, adopting appropriate feed management strategies is vital to maximize returns. The advancement in aquaculture has also allowed an advancement in the development formulated feeds to supplement or replace natural feeds. Farmers are now able to prepare their own fish feeds from locally available ingredients. Hence, feed ingredient evaluation is crucial for better development of appropriate diets for different aquaculture species as well as nutritional research. Therefore, this review used secondary data to evaluate the different strategies employed for better utilization of nutrients in feed by providing a discussion of functional feed additives used in aquafeeds such as the addition of enzymes, pre/probiotics, feeding stimulants, and use of hormones. Supplementation of diet with xynalase and phytase enzymes (

P
<
0.001

) and probiotics (

P
<
0.05

) improved growth (g/d) and FCR when applied individually. The combination of enzymes and probiotics showed an interaction effect (

P
<
0.05

) on growth and FCR. A detailed discussion of feed ingredient processing strategies like fermentation, heat treatment, germination, and other biological methods meant to improve the nutritional quality of the feed and minimize antinutritional factors is provided. Furthermore, information on how genetic selection is being used to enhance feed utilization in tilapia fish is provided. The food conversion efficiency was found to be significantly higher (

P
<
0.05

) in transgenic tilapia compared to the nontransgenic red tilapia fish with

average
 
weight
±
SD

of

384
±
158
 
g

and

314
±
101

for transgenic fish and red tilapia, respectively, after 275 days of culture. The review further outlines the feed formulation challenges, and research gaps in tilapia nutrition. It was noted that proper feeding management strategies are very critical for the sustainability of tilapia aquaculture. In conclusion, dietary sources for tilapia are slowly shifting to plant-based products. However, these come with a lot of antinutritional factors and digestibility problems; hence, the right feeding strategies have to be employed to enable efficient nutrient utilization. The review discovered that there are a lot of strategies which employed research gaps in tilapia nutrition, especially on nutrient utilization of feed and feed formulation.
First Presentation of Systemic Lupus Erythematosus in a 24-Year-Old Male following mRNA COVID-19 Vaccine
Authors: Raviv Yael , Betesh-Abay Batya , Valdman-Grinshpoun Yuliya , Boehm-Cohen Liora , Kassirer Michael , Sagy Iftach
Published: February 2022

The SARS-CoV-2 viral pandemic has had an immeasurable global impact, resulting in over 5 million deaths worldwide. Numerous vaccines were developed in an attempt to quell viral dissemination and reduce symptom severity among those infected. Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the production of antinuclear autoantibodies (ANAs) with heterogenic clinical manifestations, secondary to immune complex deposition in a multitude of organ systems. There are scarcely reported cases of SLE development following COVID-19 mRNA vaccination. We present a case of a 24-year-old male without preexisting conditions or family history of autoimmune disorders, presenting with SLE following the first dose of the SARS-CoV-2 Pfizer-BioNTech mRNA vaccine.
Serum Immune-Inflammation Index Assessment in the Patients with Ulcerative Colitis
Authors: Pakoz Zehra Betul , Ustaoglu Muge , Vatansever Sezgin , Yuksel Elif Saritas , Topal Firdevs
Published: February 2022

Radiologic and endoscopic diagnostic methods are used to determine disease activity in ulcerative colitis (UC). In order for endoscopic procedures to be invasive and to prevent radiation exposure, especially in young people, studies have been carried out frequently to determine a simple, fast, and reliable activity marker with laboratory methods. Our aim in this study is to determine the usefulness of serum immune-inflammatory index as a noninvasive marker of activation in patients with ulcerative colitis. A total of 82 consecutive patients treated with a diagnosis of ulcerative colitis were included in the study. The disease activation was assessed using the Mayo endoscopic subscore. The site of involvement was grouped into two as left colitis and extensive colitis. Patients were divided into two groups as those who had active disease based on clinical and endoscopic findings and those who were in remission. C-reactive protein (CRP) levels, platelets, neutrophils, and lymphocytes were recorded in all participants. The systemic immune-inflammation index (SII) and CRP values were compared between UC patients with active disease or remission. The correlations between CRP, SII, and Mayo endoscopic subscores were analyzed. In addition, ROC curve analysis for SII was performed to determine the cut-off value, sensitivity, and specificity in determining ulcerative colitis activity. The value of SII was significantly higher in the active group than the remission group (respectively,

1497
±
1300

and

495
±
224

,

p
<
0.001

). In the correlation analysis, a significant correlation was found between SII and Mayo subscore. In ROC curve analysis, SII was found to be significantly effective in determining activity in ulcerative colitis patients. For 0.860 area under the curve, the sensitivity was 68.1% and the specificity was 91.2% at a cut-off value of 781.5. SII is significantly higher in patients with active ulcerative colitis than those in remission. It shows promise for use as a noninvasive marker of active ulcerative colitis.
A Patient with a Novel RARS2 Variant Exhibiting Liver Involvement as a New Clinical Feature and Review of the Literature
Authors: Sevinç Selin , İnci Aslı , Ezgü Fatih S. , Eminoğlu Fatma T.
Published: February 2022

Pontocerebellar hypoplasia (PCH) is a heterogeneous neurodevelopmental disorder that is characterized by decreased brainstem and cerebellum volume. Pontocerebellar hypoplasia type 6 (PCH6) is a mitochondrial disease associated with autosomal recessive inheritance that results from mutations in the RARS2 gene. In this case report, we describe a new clinical presentation with a novel RARS2 pathogenic variant. We report here on 2 siblings who presented with neonatal lactic acidosis, microcephaly, growth retardation, persistent seizures, and cholestasis with a previously undefined RARS2 pathogenic variant. In our literature review, we evaluated the clinical features and pathogenic variants of 34 patients reported in 16 publications since the initial identification of RARS2 pathogenic variants in PCH6 in 2007. Both siblings were detected with c.1564G>A (p.Val522Ile), a novel homozygous pathogenic variant of the RARS2 gene. Imaging revealed advanced cerebral atrophy and cerebellar hypoplasia, while the basal ganglia and pons were preserved. At follow-up, the elevations in liver function test results and cholestasis had regressed while the LDH and GGT elevations persisted. Both siblings showed microcephaly on follow-up and started to suffer seizures. Severe developmental delay and nutritional problems were observed, and both died in infancy. RARS2 pathogenic variant is a mitochondrial disease that causes severe mental, motor, and developmental retardation, as well as short life expectancy. Our patients are the first cases with liver involvement in PCH6 and a novel homozygous RARS2 pathogenic variant to be reported in the literature. This additional phenotype can be considered as making a valid contribution to the literature.
Human STING Is Regulated by an Autoinhibitory Mechanism for Type I Interferon Production
Authors: Qi Shishi , Wang Changwan , Zhang Rui , Zhu Junyan , Hou Xianteng , Jiang Yingbo , Li Jiaxin , Ren Miao , Li Muwang , Hou Fajian
Published: February 2022

Stimulator of interferon genes (STING) plays a pivotal role in type I interferon-mediated innate immune response to the cytoplasmic detection of aberrant DNA. STING is a membrane protein localized in endoplasmic reticulum (ER), which upon stimulation translocates to Golgi apparatus and activates downstream signaling cascades. However, the mechanism regulating STING activity and significance of its intracellular traffic are not completely understood. Here we identify a novel region of human STING comprising thirteen residues within its C-terminal tail (CTT) for downstream nuclear factor kappa-light-chain-enhancer of activated B cell (NF-κB) activation. We also discover that STING CTT fragment can activate downstream signaling regardless of its ER localization. In addition, we reveal that ligand-binding domain (LBD) in the middle of STING binds and confers autoinhibition to its CTT for both NF-κB- and interferon regulatory factor 3-activation. Furthermore, STING LBD can inhibit the interferon-stimulating activity of STING CTT in trans and demonstrate a dominant negative effect on endogenous STING for interferon induction. We thus uncover an important autoinhibitory mechanism modulating STING activity.
Nutcracker syndrome: a case report
Authors: Khouri Thiago Elias Ferrari , Faria Isabella Rabelo , Miguel Gustavo Peixoto Soares
Published: February 2022

Nutcracker Syndrome is a rare disease of varied etiology and clinical presentation. It is described that Computed Tomography scan or Magnetic Resonance Imaging, followed by Doppler ultrasonography or venography for confirmation, are the diagnostic methods of choice. We report the case of a 35-year-old female patient who presented with macroscopic hematuria, fever and lumbar pain. She was managed with open surgical approach, the standard of care by many experts, with a double shunt performed: one between the left renal vein and the distal inferior vena cava and another between the left and right gonadal veins.
Entre a academia e os trilhos: um olhar sobre a temática ferroviária na pós-graduação da Faculdade de Arquitetura e Urbanismo da Universidade de São Paulo
Authors: Ribeiro Eduardo Bacani , Kühl Beatriz
Published: February 2022

Este estudo objetiva compreender a presença da temática ferroviária na pós-graduação da Faculdade de Arquitetura e Urbanismo da Universidade de Paulo (FAU-USP), um dos principais centros de produção acadêmica sobre arquitetura e urbanismo no país, entre a década de 1990 – momento em que o tema passa a ser identificado nos trabalhos presentes no banco de dados bibliográficos Dedalus – e o ano de 2020. Assim, por meio de pesquisa na plataforma digital da referida universidade, com subsequente leitura de títulos, resumos e assuntos de teses e dissertações em que foi identificada a presença dos termos “ferrovia(s)", “ferroviário" e “estações ferroviárias“, tabulou-se e formatou-se graficamente dados inéditos que auxiliam no entendimento de aspectos quantitativos, recortes temáticos, empíricos e espaciais, bem como tendências, lacunas e conexões presentes nesse corpus produzido ao longo de três décadas e que ainda não foi revisto historiograficamente. Espera-se que os resultados apresentados neste texto possam contribuir com trabalhos futuros que tenham por objetivo proble- matizar a temática ferroviária circunscrita à FAU-USP ou para além dela.
Pesquisa científica em museus universitários: as representações da história em pinturas e esculturas do Museu Paulista
Authors: Monteiro Michelli Cristine Scapol
Published: February 2022

O Museu Paulista da Universidade de São Paulo possui um dos mais significativos acervos de pintura e escultura, com representações históricas, que são importantes documentos para compreender a constituição de um imaginário social da história do Brasil. Este artigo tem por objetivo apresentar como esse campo de pesquisa se formou e se consolidou institucionalmente, e indicar os principais estudos acadêmicos realizados sobre esse acervo nos últimos anos. Pretende-se demonstrar a importância da pesquisa científica em museus para qualificar as atividades do ciclo curatorial, bem como as relações entre as ações de curadoria e as práticas científicas realizadas no âmbito da universidade, com que o museu interage.
Entre os muros da escola: Possibilidades para rever as noções de disciplina e avaliação
Authors: Silva Tereza Maria Trindade da , Ribeiro Henrique Melo , Campos Frederico Rodrigues
Published: February 2022

Este artigo tem como objetivo fazer uma reflexão a respeito das discussões educacionais proporcionadas com a leitura do Filme “Entre os Muros da Escola” (Entre les murs / The Class, França, 2008), dirigido por Laurent Cantet. Pretende-se discutir os aspectos da sala de aula representados no referido filme, utilizando os conceitos da etnografia, promovendo uma reflexão crítica a respeito da meritrocracia, disciplina e a avaliação
A Representação do Jogador de Futebol no Filme Linha de Passe, de Walter Salles e Daniela Thomas
Authors: Acker Ana Maria
Published: February 2022

Este artigo analisou a forma como o jogador de futebol é representado no cinema brasileiro contemporâneo – nesse caso no filme Linha de Passe (2008), de Walter Salles e Daniela Thomas. Foram verificadas, sobretudo, as implicações desse sujeito no âmbito social e esportivo. A análise se focou na obra em questão, no entanto, foram necessárias comparações com outros filmes de ficção recentes em que o futebol aparece
Lugar de Fala, Enquadramento e Valores no Caso Ângela Diniz
Authors: Lana Cecília
Published: February 2022

O presente artigo parte do entendimento da mídia como instância que está em profunda sintonia com os valores em vigência numa determinada sociedade e que é, portanto, capaz de construir, refletir, atualizar e reforçar valores e normas sociais. A proposta é identificar os “lugares de fala” construídos pelos discursos, bem como os valores e quadros de sentido acionados pela instância midiática na construção da narrativa de um crime passional específico: o assassinato de Ângela Diniz por Doca Street, ocorrido em 1976
A Educomunicação como Processo Formativo: uma abordagem sobre violência no âmbito escolar
Authors: Machado Jones , Vidoto Shelli Uílla da Rosa , Garcez Cadiani Lanes , Gonçalves Kauan Prates , Rosa Rosane
Published: February 2022

Este artigo aborda concepções de educomunicação e relata uma experiência de comunicação comunitária, a partir do projeto Educação Com & Para a Mídia. Por meio da técnica de grupo focal, aferiram-se as percepções dos conteúdos veiculados pelas mídias televisiva e impressa e a relação de fatos noticiosos a respeito da violência escolar com a realidade diária de estudantes da 6ª série do Instituto Estadual de Educação Olavo Bilac, da cidade de Santa Maria. O projeto de educação para a mídia representa uma possibilidade de que os processos comunicativo e educativo revelem-se formadores de sujeitos que exerçam de forma plena a cidadania na sociedade graças ao desenvolvimento da capacidade crítica dos indivíduos, de oportunidades de reflexão e da educação para a convivência em comunidade
O Círculo Mágico: Caminhos e Reflexões na Técnica Klauss Vianna
Authors: Vicente Nayara Cristina Zattoni
Published: February 2022

O presente artigo visa a investigação do processo criativo do ator, a partir da Técnica de conscientização e expressão corporal desenvolvida por Klauss Vianna. Para o artista cênico, esta técnica permite a ampliação de pesquisas individuais e coletivas, na medida em que propõe a percepção e a compreensão do processo evolutivo do corpo. Visa também investigar os princípios do movimento e de suas relações com o espaço em que atua. A Técnica Klauss Vianna foi aplicada e desenvolvida no Projeto de Pesquisa Corpo Sígnico, que foi concluído com a apresentação do exercício cênico “O Círculo Mágico”. Analisa-se, então, o processo de conscientização do corpo, sistematização da técnica e criação teatral durante o projeto de pesquisa