bluuebunny/crossref_metadata_2025 huggingface dataset:
Reliability Analysis and Life Cycle Cost Optimization of Hydraulic Excavator
Authors: Mishra Sandeep Kumar , Goyal Neeraj Kumar , Mukherjee Arup
Published: March 2024

This study focuses on conducting a reliability analysis of an excavator from its field failure data and improve its reliability cost effectively. The aim of the research is to perform reliability estimation of systems and identify the critical subsystem with significant contributions to system unreliability. The reliability analysis was performed using repairable system data analysis approaches. Life cycle cost (LCC) was estimated for critical subsystems, and it was optimized to select cost effective reliability improvement strategy. The results of the study provide valuable insights into the performance and cost-effectiveness of the excavator and its subsystems, which can assist manufacturers and operators in optimizing their equipment’s reliability, availability while considering the cost implications over the life cycle of the equipment. The results show that the undercarriage has critical contributions to system unreliability. This study attempts deep down reliability analysis of critical undercarriage components for optimal selection of improvement method among feasible alternatives. LCC analysis and its optimization performed on the critical sub-system is expected to help OEM save approx. 15% of LCC. The empirical data used in the paper is based on field data gathered during the operational life of the hydraulic excavator over approx. six years in its Indian operations.
Two-channel optimal energy-efficient control of distributed parameter systems
Authors: Ilina Natalya A.
Published: March 2024

A formulation and method for solving the problem of the energy-efficient two-channel programmed control of an object with distributed parameters with a given-precision uniform approximation of the resulting spatial distribution of the controlled quantity to the required state is proposed. Two internal controls on the power of heat sources in the electromagnetic field of the inductor are considered as control actions. Proposed solution approach involves a special-form preliminary parametrization procedure for control actions on finite-dimensional subsets of the terminal values of conjugate variables in the boundary-value problem of Pontryagin’s maximum principle, in combination with the subsequent reduction to a semi-infinite optimization problem, which is solved with respect to the requisite parameter vector using the alternance method based on additional information about fundamental laws of the subject area. An example of optimal energy-efficient control of transient heat conduction, which is of independent interest, is given.
Managing the staffing process of the Samara region oil industry
Authors: Tuponosova Elena P. , Livshits Mikhail Y. , Golovanov Pavel A.
Published: March 2024

The problem of constructing dynamic models in the form of differential equations or transfer functions linking the performance indicators of the oil industry of the Samara region with the performance indicators of a regional university with a large institute of oil and gas technologies, considered as the controlling factors of staffing the oil industry, is solved. The input factors of the model are the normative performance indicators of the Samara State Technical University (SamSTU). The effectiveness of the regional oil cluster of the Samara region is assessed by indicators established by the Federal State Statistics Service (Rosstat), in particular, the amount of oil received for processing. For the algorithm of personnel management of the oil industry of the region, the problem of structural and parametric identification of the personnel training process at the university based on statistical characteristics as experimental data is solved. Using the library of typical linear models of management objects by N.S. Raibman, mathematical models of the process of staffing the industry in the form of transfer functions are constructed. Verification of mathematical models is carried out by comparison with official statistical data. On the basis of the obtained transfer functions, the synthesis of algorithms for automatic management of the personnel management process of the regulatory industry in the management decision support system is carried out.
Modeling of thermal processes when melting ice on power lines
Authors: Bazarov Aleksandr A. , Budko Stepan I.
Published: March 2024

An analysis of the problem of ice formation on power line wires was carried out, and a review of work in the field of melting ice on various lines was carried out. Existing achievements and problems are noted. One of the reasons for the low equipment of lines with automated melting systems is the need to transfer the line from the operating state to the melting mode. One way to solve the problem is to combine these modes by loading the line with additional current without increasing the power transmitted to consumers. A set of issues on modeling thermal processes in the ice shell of power line wires during ice melting is considered. Limiting the power of heat generation in wires leads to the need to build a sufficiently accurate mathematical model to guarantee melting at different values of wind speed and temperature. A study of wire heating processes was carried out using models of stationary and non-stationary thermal conductivity. An algorithm is proposed for solving the thermal problem when a heated wire penetrates an ice shell, based on simulating the movement of the interface between the solid and liquid phases of water. The features of modeling the melting and crystallization process using a numerical method are described. When ice transitions to a molten state, melting reflects a change in density and the formation of an air gap, accompanied by a significant decrease in heat flows to the lower region of the ice shell. The results of numerical modeling of the process of melting an ice shell with a wire at different values of the convective heat transfer coefficient are presented. When analyzing the modeling results, conditions were identified for the occurrence of unacceptable overheating of a wire freed from ice. Various options for constructing a control system for the smelting process have been proposed to prevent overheating of the wire.
Measurement of electrical conductivity of transformer oil based nanofluid
Authors: Korobejnikov Sergej M. , Shevchenko V. E. , Rydel Alexander V. , Goreva Ludmila P.
Published: March 2024

In this article, an attempt was made to evaluate the electrical conductivity of ananofluid based on transformer oil. For this purpose, several nanofluid samples with different concentrations of dielectric silicon dioxide nanoparticles and conductive zinc nanoparticles were prepared. The dielectric permittivity and electrical conductivity of the obtained nanofluids were measured experimentally. After processing the experimental results, a theoretical calculation was made using the Nielsen formula. After the calculation, the results were compared with the experimental data. In the process of comparative analysis, the correspondence of the calculated and experimental values of the dielectric permittivity was noted. There was also a discrepancy between the experimental and calculated values of electrical conductivity. An explanation is proposed for the discovered discrepancy between the calculated and experimental values. Presumably, the main reason for the decrease in electrical conductivity in the experiment is the adsorption of ion particles in the dielectric.
Investigation of the thermal regime of a linear DC motor
Authors: Makarichev Yury A. , Ratzev Yaroslav A.
Published: March 2024

Linear DC motors (LDPT) with a limited armature stroke are used in mechanisms that reciprocate the working body or stabilize its position in tracking systems. The use of LDPT instead of rotary motion motors with a converter in the form of a crank mechanism, a screw pair or other similar mechanical systems leads to a significant simplification of the kinematic scheme, increased efficiency and, as a rule, increased accuracy of the complex and its reliability. There are a number of problems in the creation of LDPT, which are not fully reflected in the scientific and technical literature. In particular, with parametric optimization of the engine according to weight, size and energy criteria, one of the main limiters is overheating of the winding, and in magnetoelectric machines, also overheating of permanent magnets, which are very sensitive to the magnitude of the operating temperature and thermal shocks. The article presents an analytical method for calculating the thermal state of an engine in steady state, based on the method of thermal substitution schemes. The technique is designed for use in a parametric optimization program. To clarify the values of the a priori coefficients in the analytical expressions of the proposed algorithm, the authors modeled the LDPT using the numerical finite element method. Based on the simulation results, a picture of the temperature field of the machine was obtained and the critical heating areas were determined. Verification of the theoretical provisions was carried out during experimental studies of the prototype engine. The tests showed good convergence of the calculated and experimental parameters.
Morphometric and Densitometric Analysis of Heterochromatin during Cell Differentiation Using the Leukaemic Granulocytic Lineage as a Convenient Model
Authors: Smetana Karel , Mikulenková D. , Klamová H.
Published: March 2024

Granulocytic early progenitors and terminally differentiated – mature granulocytes with segmented nuclei were studied using computer-assisted diameter and heterochromatin optical image densitometry to provide more information on the nuclear size and heterochromatin condensation state. Bone marrow smears of patients suffering from chronic myeloid leukaemia untreated as well as treated with “specific” anti-leukaemic therapy with imatinib mesylate are a convenient model for such study because they possess a satisfactory number of cells for diameter and optical density measurements. In addition, the identification of developmental stages of granulocytes is very easy and the morphology is not different from that in not-leukaemic persons. As it was expected, the mean diameter of nuclear segments in fully differentiated and mature granulocytes was much smaller than that in non-segmented nuclei of early granulocytic precursors. Therefore, no wonder that the heterochromatin condensation state in nuclear segments of mature granulocytes was much larger than in non-segmented nuclei of granulocytic progenitors. On the other hand, the sum of mean diameters of all nuclear segments per cell was close to the mean nuclear diameter of early granulocytic progenitors. The heterochromatin condensation state in granulocytic progenitors or fully differentiated mature granulocytes exhibited marked stability and did not change after the anti-leukaemic therapy. In addition, Barr bodies of characteristic drumstick appearance bearing inactive X chromosome in interphase nuclei of mature granulocytes in fertile female patients exhibited a heterochromatin condensation state similar to nuclear segments. This heterochromatin condensation state was also stable and constant, and was not apparently influenced by the anti-leukaemic therapy.
A Mutation of the Prdm9 Mouse Hybrid Sterility Gene Carried by a Transgene
Authors: Mihola O. , Trachtulec Zdenek
Published: March 2024

PRDM9 is a protein with histone-3-methyltransferase activity, which specifies the sites of meiotic recombination in mammals. Deficiency of the Prdm9 gene in the laboratory mouse results in complete arrest of the meiotic prophase of both sexes. Moreover, the combination of certain PRDM9 alleles from different mouse subspecies causes hybrid sterility, e.g., the male-specific meiotic arrest found in the (PWD/Ph × C57BL/6J)F1 animals. The fertility of all these mice can be rescued using a Prdm9-containing transgene. Here we characterized a transgene made from the clone RP24-346I22 that was expected to encompass the entire Prdm9 gene. Both (PWD/Ph × C57BL/6J)F1 intersubspecific hybrid males and Prdm9-deficient laboratory mice of both sexes carrying this transgene remained sterile, suggesting that Prdm9 inactivation occurred in the Tg(RP24-346I22) transgenics. Indeed, comparative qRT-PCR analysis of testicular RNAs from transgene-positive versus negative animals revealed similar expression levels of Prdm9 mRNAs from the exons encoding the C-terminal part of the protein but elevated expression from the regions coding for the N-terminus of PRDM9, indicating that the transgenic carries a new null Prdm9 allele. Two naturally occurring alternative Prdm9 mRNA isoforms were overexpressed in Tg(RP24-346I22), one formed via splicing to a 3’-terminal exon consisting of short interspersed element B2 and one isoform including an alternative internal exon of 28 base pairs. However, the overexpression of these alternative transcripts was apparently insufficient for Prdm9 function or for increasing the fertility of the hybrid males.
The Influence of Sodium Fluoride on the Growth of Ameloblasts and Kidney Proximal Tubular Cells
Authors: Wahluyo Soegeng , Ismiyatin K. , Purwanto B. , Mukono I. S.
Published: March 2024

Fluoride has toxic potential particularly for teeth, bones, and kidney. This study was aimed to investigate the NaF exposure effects on the growth of ameloblasts and kidney proximal tubular cells. Adult male healthy rats were used as experiment models, divided into control and NaF-induced groups. The expression of amelogenin, Bcl-2, and caspase-3 were significantly different in the control and NaF-induced group (P < 0.05). There was no correlation among these proteins in the control group but significant correlation in the NaF-induced group (r = 0.694). There was a significant correlation in proximal tubular cells, as seen from the increase of caspase-3 in the NaF-induced group (r = 0.715).
Phonetic loan, graphic borrowing, and script-mixing: key to the vitality of written Cantonese in Hong Kong
Authors: Li David C. S. , Tak-sum Wong
Published: March 2024

This study aims at investigating how loanwords from Japanese and Korean are used in informal written Cantonese media discourse, including print and social media. Data from these media were collected from designated websites for 15 min every other day over a two-week period. The results show that loanwords from Korean, being written in a phonographic scripthangul(한글), are rendered into written Cantonese typically through phonetic adaptation using Chinese morpho-syllables, while their Chinese-specific morphographic meanings are ignored. By contrast, lexical items from Japanese written inkanjitend to be borrowed directly through graphic borrowing, paying no regard to their Japanese pronunciation. Japanese being written with mixed scripts,kanjiand twokanasyllabaries, graphic borrowing fromhiraganaorkatakanais rare, with the Japanese grammatical particle の being a notable exception. We conclude that lexical items written in a phonographic script tend to be rendered into written Cantonese phonetically, while those written in character-basedhànzìare borrowed directly through graphic borrowing but assigned Cantonese pronunciation. In informal interaction between Cantonese-dominant Hongkongers, colloquial written Cantonese relies on the affordance of script mixing for its vitality, in print as much as in internet-mediated social media discourse.
Magnetic alginate supported potassium manganese ferrocyanide for the recovery of uranium from acidic wastewater
Authors: Li Tingting , Wang Fang , Xia Liangshu
Published: March 2024

With the rapid development of the atomic energy industry, the demand for nuclear fuel has risen, while the limited resources of uranium mines make it difficult to meet the needs of the future development of nuclear energy. Expanding sources of uranium acquisition is necessary, and the enrichment and recovery of precious uranium from uranium-containing wastewater is invaluable. By synthesizing alginate supported potassium manganese ferrocyanide nanocomposites with magnetic response (KMnFC/MA/Fe3O4), the high efficiency adsorption and separation of uranium in acidic uranium-containing wastewater can be realized conveniently and quickly. The magnetic composite was characterized by a variety of technical means, and the adsorption behavior of the magnetic material on uranium was studied by static adsorption experiments under different environmental conditions. The adsorption kinetics and isotherm of uranium by KMnFC/MA/Fe3O4 were studied by using some common linear adsorption models. The results show that the adsorption rate of KMnFC/MA/Fe3O4 on uranium is fast, and the adsorption equilibrium can be reached within 90 min. The adsorption process conforms to a pseudo-secondary kinetic model and is dominated by chemisorption. The adsorption of uranium by KMnFC/MA/Fe3O4 magnetic material is single molecular layer adsorption, and the maximum adsorption capacity is 425.5 mg g−1 at 35 °C. KMnFC/MA/Fe3O4 is a promising adsorbent in the field of acidic low-concentration uranium wastewater treatment because of its good effect on the treatment of low concentration uranium wastewater, the concentration of uranium in the wastewater reaches the emission standard after treatment and it is easy to be separated magnetically after adsorption.
Az aphasia zeneterápiájának módszerei, azok direkt és indirekt hatásai
Authors: Juhos-Kiss Eszter , Pusztafalvi Henriette
Published: March 2024

Bevezetés: A zeneterapeuták ma még nem megszokott tagjai a hazai
neurológiai és rehabilitációs osztályokon működő szakmai csoportoknak, így a
zeneterápia sem természetes része a klinikai gyakorlatban alkalmazott kezelési
programoknak. Az elmúlt fél évszázadban számos hazai, de különösen nemzetközi
tanulmány született a neurológiai zeneterápia eredményeinek bemutatására.
Célkitűzés: A jelen munka az aphasia zeneterápiájának
direkt és indirekt hatásait hivatott bemutatni, ezzel is alátámasztva annak
relevanciáját. A tanulmány célja a zenei alapú aphasiaterápiás módszerek
bemutatása és elfogadtatása a hazai szakemberek körében, valamint alkalmazásának
elősegítése a klinikai gyakorlatban. Módszer: Az aphasia
zeneterápiájának direkt hatásaira irányuló vizsgálathoz a magyar és angol nyelvű
szakirodalomból 16 tanulmányt választottunk ki az általunk megszabott
kritériumok alapján, melyek összesen 9 különböző módszert mutatnak be. Közülük 7
módszerhez terápiás intervenció is kapcsolódik, melyek számszerűsített
eredményeit táblázatban összesítettük. Tanulmányunk kitér az aphasiás
személyekkel végzett zeneterápiás foglalkozások indirekt hatásaira is. A
szekunder hatásokat saját szerkesztésű kérdőívvel mértük. A felmérést a 2021 és
2023 között általunk egyéni terápiába vont 28 páciens körében végeztük.
Eredmények: Az így kapott eredményeket táblázatban
rögzítettük. A zenei alapokra épülő aphasiaterápiák vizsgálati alanyainak
83%-ában szignifikáns javulást mértek valamely nyelvi területen a terápiás
folyamat végén. A saját pácienseink körében végzett kérdőíves felmérés alapján
pedig elmondható, hogy a zenei alapú terápia pozitív hatásai indirekt módon,
emocionális szinten is érvényesültek. Az aphasia zeneterápiájának a fellelt
szakirodalomban közölt direkt hatásai mellett a járulékos hatások terén is
pozitív eredményt mértünk a kutatásunkba bevont résztvevők általános hangulatára
és motivációjára vonatkozóan. Következtetés: A bemutatott
eredmények tükrében arra következtetünk, hogy a nyugati minták példájára
hazánkban is indokolt lenne nagyobb hangsúlyt fektetni az alternatív
gyógymódoknak a klinikai gyakorlatba történő integrálására. Orv Hetil. 2024;
165(11): 424–432.
A Turner-szindróma áttekintése az újabb genetikai ismeretek és a multidiszciplináris beteggondozás tekintetében
Authors: Beniczky Nikolett Jusztina , Szücs Nikolette , Gellén Balázs , Bertalan Rita Ágnes
Published: March 2024

A Turner-szindróma női fenotípussal járó komplex betegség, melynek oka az egyik
X-kromoszóma teljes vagy részleges hiánya. Előfordulási gyakorisága leány
újszülött esetén 1/2000–2500. A legújabb diagnosztikus kritériumok, a genetikai
háttér egyre pontosabb ismerete, a terápiás lehetőségek fejlődése és az egyre
részletesebb gondozási protokollok segítséget nyújtanak a betegség minél korábbi
felismeréséhez és a betegek életminőségének nagy fokú javításához. A
beteggondozás legfontosabb eleme minden életkorban a multidiszciplináris
ellátás, mivel a Turner-szindrómás pácienseknél a különböző életszakaszokban más
és más, de egyszerre akár több tünet, illetve betegség vagy szövődmény
manifesztálódása is várható. A szindrómához társuló fenotípusbeli eltérések nagy
variációt mutatnak. Leggyakoribb tünete az alacsony termet, a petefészek
dysgenesise által okozott hypogonadismus és következményes késői vagy elmaradt
pubertas. Graviditás csupán 4,8–7,6%-ban fordul elő. A testi elváltozások
mellett több szervrendszer érintett, így várható különböző, Turner-szindrómával
összefüggő betegségek – úgymint veleszületett szív- és vesefejlődési
rendellenességek, vérnyomáseltérés, fülészeti, szemészeti, pajzsmirigy-, ortopéd
betegségek, neurokognitív diszfunkció, a csont-ásványianyag csökkenése és
autoimmun betegségek – előfordulása is. Összefoglalónk célja, hogy segítséget
nyújtson a Turner-szindrómás betegek minél korábbi diagnosztizálásához és az
élethosszig tartó teljes körű beteggondozáshoz, különös tekintettel
endokrinológiai és kardiológiai ellátásukra. Orv Hetil. 2024; 165(11):
416–423.
Kritikus állapotú, szeptikus felnőtt betegek antibiotikumkezelésének farmakokinetikai és farmakodinamikai megfontolásai
Authors: Holub Lili , Szabó Bálint Gergely , Závorszky Lőrinc , Hümpfner Rózsa , Andréka Péter , Karvaly Gellért Balázs , Lakatos Botond
Published: March 2024

A szepszis életet veszélyeztető, komplex klinikai állapot, melynek kezelése
jelentős kihívást és számottevő költségráfordítást jelent a betegellátás
számára. A szepszis által előidézett patofiziológiai változások jelentős
mértékben megváltoztatják a gyógyszerek és a szervezet kölcsönhatását,
megnehezítve az optimális gyógyszerelést. A kapillárisszivárgás jelensége,
valamint az ellátás során alkalmazott folyadékterápia hatására megemelkedhet
egyes antibiotikumok megoszlási térfogata. A hypalbuminaemia következtében
megnövekedett szabad frakció a nagy fehérjekötődésű antibiotikumok gyorsabb
eliminációját okozhatja. A megnövekedett perctérfogat és a vascularis ellenállás
csökkenése a fiatalabb betegpopulációkban megnövekedett renalis clearance-t
idézhet elő. A betegek nagyobb hányadában azonban a hipoperfúzió miatt szepszis
indukálta akut veseelégtelenség jellemző, melynek hatására a renalis clearance
csökken. A klinikai képet tovább árnyalja, ha vesepótló vagy extracorporalis
membránoxigenizációs kezelést alkalmazunk. Az antibiotikumok fizikai-kémiai
jellemzői meghatározzák, hogy a patofiziológiai változások milyen mértékben
befolyásolják az egyes gyógyszermolekulák farmakokinetikai paramétereit. A
várttól eltérő gyógyszer-expozíciót előidéző folyamatok ellensúlyozására a
farmakokinetikai-farmakodinamikai indexek, valamint a fizikokémiai értékek
ismeretében többféle klinikai stratégia áll rendelkezésre. A terápia racionális
szempontok szerint történő személyre szabásával és a terápiás gyógyszerszint
monitorozásával növelhető a hatékonyság, és csökkenthető az
antibiotikumrezisztencia kialakulásának esélye. Orv Hetil. 2024; 165(11):
403–415.
Features of the clinical course of anaplastic lymphoma in children. Clinical case
Authors:   National Pirogov Мemorial Medical University, Vinnytsya, Ukraine, Dudnyk V.M. , Furman V.H. ,   National Pirogov Мemorial Medical University, Vinnytsya, Ukraine, Kutsak O.V. ,   National Pirogov Мemorial Medical University, Vinnytsya, Ukraine, Pasik V.Yu. ,   National Pirogov Мemorial Medical University, Vinnytsya, Ukraine
Published: March 2024

Anaplastic large cell lymphoma (ALCL) is a rare type of T-cell non-Hodgkin lymphoma with a characteristic primary localized, mainly extra-bone marrow tumor growth of lymphoid tissue, the clinical picture of which includes lesions of peripheral lymph nodes and extranodal organs, such as bones, skin, lungs, liver, muscles which tissues and bone marrow. Purpose - to acquaint practicing doctors with the features of clinical manifestations, differential diagnosis and course of ALCL in children. Features of the clinical course of ALCL in a child are described. The main diagnostic value of the anamnesis, clinical picture, laboratory, instrumental, immunohistochemical and microscopic research methods, in particular trepan biopsy of this tumor, is highlighted. Microscopic examination of the tissue trepanbioptate show that in half of the cells of the bone marrow, its normal structure is revealed, hematopoietic bone marrow is present with the preservation of all sprouts, with a slightly increased number of megakaryocytes. Half of the cells are filled with solid layers of sharply atypical lymphocyte-like cells with a moderate amount of eosinophilic cytoplasm, the nuclei of tumor cells are large, vesicular, with the formation of 1-2 basophilic nuclei. In the tumor cells there are figures of mitosis, including atypical ones. Single hematopoietic cells of various germs are found between these cells. The conducted immunohistochemical study of tumor cells show that they are positive for common leukocyte antigen (CD4), negative for common cytokeratins, S-100, myogenin, MuoD1, which indicates their hematopoietic origin. Upon further examination, the tumor cells were positive for CD 30, negative for CD3, CD20, CD 43, CD 68, CD11c, tdt, myeloperoxidase, CD 1a. Staining for CD246 reveals a granular cytoplasmic reaction in tumor cells. The histological pattern and immunophenotype of tumor cells correspond to ALCL. The research was carried out in accordance with the principles of the Helsinki Declaration. The informed consent of the patient was obtained for conducting the studies. No conflict of interests was declared by the authors.
Prediction of the risk of development of autistic spectrum disorders in children with epileptic encephalopathies
Authors:   SI Institute of Pediatrics, Obstetrics and Gynecology named after academician O.M. Lukyanova of the NAMS of Ukraine, Kyiv, Miroshnykov O.O.
Published: March 2024

Predicting the risk of developing autism spectrum disorders (ASD) in children with epileptic encephalopathies (EE) is an important task, which makes it possible to identify the most significant risk factors and develop ways of their modification. Purpose - to develop a model for predicting the risk of developing ASD in young children with EE. Materials and methods. 75 children aged 0-3 years with the onset of epileptic seizures in the first year of life, clinical manifestations of EE were examined. The most informative clinical, neurophysiological, and neuroimaging indicators for predicting the risk of clinical manifestations of ASD were determined: age of onset of epileptic seizures, index of spike-wave activity during NREM sleep, frequency and amplitude of alpha rhythm, frequency and amplitude of epileptiform activity, fractional anisotropy and mean diffusion coefficient in the Broca’s center, fractional anisotropy in the Wernicke center and knee of the corpus callosum. The multiple linear regression method was used to predict the risk of developing ASD symptoms. Results. A model for predicting the risk of developing clinical manifestations of ASD in children with EE has been developed. It was established that the risk of developing clinical manifestations of ASD increases with a decrease in the age of onset of epileptic seizures, decrease in the frequency and amplitude of the alpha rhythm according to electroencephalography (EEG) data, increase of the index of spike-wave activity, frequency and amplitude of epileptiform activity, increase in the index of fractional anisotropy in the anterior part of the arcuate tract, decrease in the average diffusion coefficient in the area of the Broca’s center, fractional anisotropy in the Wernicke center and the knee of the corpus callosum according to magnetic resonance tractography. Conclusions. A regression model for predicting the risk of clinical manifestations of ASD in children with EE was developed with an average error of approximation of 13.2% and a coefficient of determination of 0.74, which is recommended for use in clinical practice in order to form groups of children at high risk of ASD. Such children require further dynamic monitoring and early intervention by specialists of a multidisciplinary team for timely identification and correction of ASD symptoms The research was carried out in accordance with the principles of the Helsinki Declaration. The study protocol was approved by the Local Ethics Committee of the participating institution. The informed consent of the patient was obtained for conducting the studies. No conflict of interests was declared by the author.
Treatment of infantile hemangioma with topical β-blockers in pediatric practice: a review of the literature
Authors:   Ukrainian Military Medical Academy, Kyiv, Bogomolets O.V. ,   Academy of Silesia, Katowice, Poland,   Dr. Bogomolets’ Institute of Dermatology and Cosmetology, Kyiv, Ukraine, Selyuk O.V. ,   Ukrainian Military Medical Academy, Kyiv, Bogomolets K.P. ,   Dr. Bogomolets’ Institute of Dermatology and Cosmetology, Kyiv, Ukraine, Bogomolets-Sheremetieva S.O. ,   Dr. Bogomolets’ Institute of Dermatology and Cosmetology, Kyiv, Ukraine,   Bogomolets National Medical University, Kyiv, Ukraine
Published: March 2024

The purpose of this review is to acquaint the audience with the benefits of infantile hemangioma (IH) treatment with local β-blockers, which are safe for the child, allow for the complete cure of hemangiomas without surgery, complications, scars, and cosmetic defects, and have practically no systemic side effects. We aimed to analyze the effectiveness and limitations of the use of local β-blockers, to show the possibility and expediency of IH management in pediatric practice, and to demonstrate that the goal of therapy is not the treatment of complications, but the prevention of their occurrence and complete resolution of the hemangioma without surgical intervention. The use of topical β-blockers, such as timolol gel or solution, provides a non-surgical, non-invasive treatment option for IH, minimizing the systemic exposure and possible side effects associated with oral β-blockers. Local treatment is best started before the age of 2 months - at an early stage, when IHs are small in size, potentially preventing the need for more invasive treatment methods. Topical use is associated with a lower risk of systemic side effects, such as hypotension or bradycardia, that can occur with oral β-blockers. Topical treatment can be applied at home, which can be more convenient for parents and caregivers, and also increases the opportunity for treatment and follow-up by pediatricians. In case of natural disasters or military operations, treatment can be done remotely using teledermatology. The effectiveness of local β-blockers mostly depends on the age at which treatment was started: the earlier it was started, the higher the effectiveness. Treatment of complicated IH with deep soft tissue, mucosal, or airway involvement usually requires a combination of systemic propranolol and topical β-blockers or other interventions such as laser therapy. The choice of treatment should be selected individually according to the degree of risk of IH, its size, localization, child's age, weight, and other parameters in each clinical case. β-adrenoblockers are the most modern, effective, non-surgical, and safe method of treating IH, they can be used both for systemic and local application. IH can be successfully treated by pediatricians and dermatologists. No conflict of interests was declared by the authors.
International classification of diseases - 11: what do you need to know regarding upper respiratory tract injuries? Questions and answers
Authors:   Shupyk National Healthcare University of Ukraine, Kyiv, Beketova H.V. , Popovych V.I. ,   Higher Private Educational Institution Lviv Medical University, Ukraine
Published: March 2024

Purpose - to draw the attention of physicians to the structure of the International Classification of Diseases, the 11th Revision (ICD-11) for use in clinical practice using the example of nosological forms of tonsillitis. The question-and-answer format provides up-to-date information on the main provisions of ICD-11, which was implemented worldwide from 01.01.2022. The attention of doctors is focused on the nosological approach in its structure. Using the example of acute and recurrent tonsillitis, it is shown how to use the new statistical classification of diseases correctly, and answers are given to the questions most often asked by practitioners when making a diagnosis according to this classification. Conclusions. ICD-11, in addition to statistical needs, adds clinical needs and more, moving the ICD from a simple statistical database to a clinical classification for statistical use. Based on the most up-to-date clinical and epidemiological data and the results of double-blind, randomised, placebo-controlled trials, ICD-11 is synchronized with current clinical guidelines to help clinicians make informed decisions. No conflict of interests was declared by the authors.
Gallstone disease in children
Authors:   Bogomolets National Medical University, Kyiv, Ukraine, Bobrova V.I. , Proshchenko J.I. ,   Bogomolets National Medical University, Kyiv, Ukraine, Pavliuchenko K.S. ,   Uzhhorod National University, Ukraine
Published: March 2024

The prevalence of gallstone disease among children is 0.13-1.9%. Cholelithiasis in children is a multifactorial disorder. Scientific data analysis indicates a diversity of pathogenetic mechanism of gallstone formation. The purpose of the review is to summarize the scientific data about risk factors, clinical features, diagnosis and treatment of gallstone disease in children. Based on the literature data, the main factors for the disease are genetic, metabolic, low-calorie diet, nutritional disorders, liver and small intestine diseases. The main pathogenetic mechanisms of gallstone formation are liver dyscholia, disorders of enterohepatic circulation of bile acids, increased erythrocyte hemolysis and erythrocyte enzyme system insufficiency, a decrease in hepatic enzyme activity, impairment of gallbladder motility due to decreased sensitivity to cholecystokinin. Most children undergo asymptomatic gallstone disease: clinical features are absent, concrements in the gallbladder or bile ducts appear as accidental findings during ultrasound examination. The first stage of diagnosing cholelithiasis is an abdominal ultrasound examination. In case of absence of concrements during ultrasound examination and presence of typical clinical picture of cholelithiasis, endoscopic ultrasound and magnetic resonance cholangiopancreatography are prescribed. To reduce biliary pain, non-steroidal anti-inflammatory drugs and analgesics are required. The only way to treat symptomatic form of gallstone disease is cholecystectomy. The asymptomatic form is subject to observation without treatment. For the treatment and prevention of cholelithiasis, it is not recommended to take bile acid preparations due to the low effectiveness and frequency of relapses in the formation of stones after their complete dissolution. Conclusions. The incidence of gallstone disease among children and adolescents increases and more than half of patients has asymptomatic form. During the treatment of patients with cholelithiasis, cholecystectomy or observation tactics are used, depending on the clinical form of the disease. Prevention of gallstone disease relies on healthy lifestyle, weight loss for the obese children, physical activity, diet high in fiber and calcium. The authors declare that they have no conflicts of interest.
Non-surgical management of right post cervical uterine torsion during terminal stages of parturition in a graded murrah buffalo
Authors: Mohan P. , Jahangirbasha D. , Renukaradhya G. J. , Sarangamath Santosh P.
Published: March 2024

A graded Murrah buffalo aged above six years and in its second lactation was brought to the department of Veterinary Gynaecology and Obstetrics, Veterinary College, Gadag. The history revealed that completion of gestation period, straining since three days. By per rectal examination right side torsion was diagnosed and relieved by applying Schaffer’s method. During the correction oof torsion after first rotation, gushing of fluids from the uterus was observed. On pervaginal examination carpal flexion was found. After correcting carpal flexion by applying traction a male dead fetus was removed.
A comparative analysis of arecanut based cropping system in Uttara Kannada district
Authors: Hebbur Lekhan N. , Gotyal S. H. , Aski S. G.
Published: March 2024

The study was conducted in Uttara Kannada district which comes under the jurisdiction of UAS, Dharwad during the year 2021-2022. To make comparative analysis of arecanut based cropping system by employing “Ex-post facto” research design and by using simple random sampling technique in Uttara Kannada district constituting a total sample size of 120 farmers. It was revealed that, 77.50 per cent of sole crop and 65.00 per cent of multiple cropping growers adopted Sirsi local variety, 77.50 per cent of sole crop growers done planting during May-August and 65.00 per cent of multiple cropping growers done planting during August-September, 95.00 per cent of multiple cropping growers adopted 2.7×2.7m spacing, 47.50 per cent of multiple cropping growers adopted square system of layout, 47.50 per cent of sole crop growers adopted covering of stem, 52.50 per cent of sole crop growers adopted method of fertilizer application, 67.50 per cent of sole crop growers adopted depth of drainage, 75.00 per cent of sole crop growers adopted mulching, both sole and multiple cropping growers adopted manual method of harvesting and 92.50 per cent of sole crop growers go for rashi type of processing to get maximum profit. There is enough scope to encourage adoption of arecanut based cropping system by using mass contact methods and concerned transfer of technology centers. Thus, the efforts should be made to conduct training programmes and demonstrations.So, it is another vital thing that needs to be given priority to adoption of production technology.
Effects of post-shooting sprays and bunch covering on yield attributes of Willium banana (Musa paradisiaca L.)
Authors: Paradva D. R. , Patel M. J. , Ram Bhavin , Kacha H. L.
Published: March 2024

This research investigates the synergistic effects of post-shooting sprays and bunch covering materials on the growth, development, and yield of Willium banana (Musa paradisiaca L.). Gibberellic acid (GA3) at 100 mg/l emerges as a potent post-shooting spray, significantly enhancing bunch length, finger length, girth of finger, bunch weight, and overall fruit yield. The study highlights the pivotal role of GA3 in promoting both cell division and elongation, contributing to increased fruit size and weight. Non-woven material bag covering proves superior in creating an optimal microclimate, fostering enhanced air circulation, temperature control, and light interception. This material significantly boosts finger length, girth, bunch weight, and fruit yield. These findings provide valuable insights for banana cultivation, emphasizing the strategic use of GA3 and appropriate covering materials to optimize environmental conditions and hormonal balance for improved crop outcomes. The study contributes to the evolving field of banana cultivation practices and offers practical implications for enhancing fruit quality and yield.
Incidence of canine reproductive cases presented to veterinary college Gadag, during 2021-2023
Authors: Mohan P. , Jahangirbasha D. , Renukaradhya G. J. , Ballari Shashidhar
Published: March 2024

A study on the incidence of gynaecological cases in canines was presented between April 2021andMarch 2023 at the Department of Veterinary Gynaecology and Obstetrics, Veterinary College Gadag. A total of 374 gynaecological cases were presented. The highest incidence was found to be Exfoliative Vaginal Cytology (36.10%), followed by Pregnancy Diagnosis (26.74%), Birth control (7.49%), Tumour (7.22%), Assisted mating and AI (7.22%), Pyometra (6.15%), Anoestrous (4.28%), Mismating (2.41%), Dystocia (1.34%) and Retention of Fetal Membranes (1.07%). Breed-wisepredilection indicated that Labrador Retriever(32.89%), Golden Retriever (10.70%), German Shepherd (10.70%), Rottweiler (9.63%) and others(36.10%).The majority of cases were presented during Winter (29.94%), followed by Monsoon (25.94%), Autumn (22.73%) and Summer (21.39%).
Influence of bio-fertilizer on morphology and yield of cowpea [Vigna unguiculata (L.) Walp]
Authors: Ramesh G. , Rao P. Srinivasa , Rao Ch. Bhaskara , Anujya Chilaka
Published: March 2024

A field experiment is carried out at agriculture field of Agriculture Research Station, Amaravathi to study the influence of different levels of Jeevamrutha, seaweed and KNF (Korean Natural Farming). The main concept of this research workis to apply a mineral source in the form of Korean Natural forming, involving the culturing of Indigenous Micro Organisms (IMO). KNF emphasizes self sufficiency by limiting externals inputs and relyingonre cycled farm waste to produce biologically active inputs. The application of this method has given more yield in cowpea.The results reveals that application of jeevamrutha at 1000 lha-1 3% of sea weed Sargassumswartzii (SSE) and KNF at 5-3-2 nutriarichpellets, significantly influenced growth parameters like plant height, number of branches, number of leaves, number of pods per plant, length of pods, number of seeds per pod, seeds weight per plant and 100 seed weight.Application of KNF is more affective in producing higher grain yield in cowpea.
Fabrication of continuous solar dryer for fruits and vegetables slices
Authors: Vikas L. , Patil H.S. Ravikumar , Kandkur Shivabasappa , Gowda L. Harhavardan
Published: March 2024

The world population is more than 8 billion and about 20-25 per cent people does not have enough food to eat. It has been estimated that world as a whole more than 30-50 per cent vegetables, fruits etc. are lost before it reaches to the consumers. To overcoming spoiling problems of vegetables and fruit; various preserving methods are used and renewable sources are best for this purpose by which we can save energy for preservation and keeping the product in their natural flavor by drying it.Drying is one of the oldest methods of preserving food. The solar drying system utilizes solar energy to heat air and to dry any food substance. It brings about a substantial reduction in weight, volume, minimizing packing, storage, and transportation costs, and enables storability of the product under ambient temperatures. This paper present the Construction of Continuous solar dryer which can be used for drying various fruits and vegetables products in rural areas under hygienic conditions. The Continues solar dryer was constructed consisting of a solar collector cum drying chamber. The overall dimension of the continues solar dryer is 1830×300×620mm and the drying chamber was painted black to absorb maximum solar radiations. The glass was covered it permits the solar radiation into the system but resists flow of heat energy out of system and product were moving continually from inlet to outlet through chain conveyors. This chain conveyors was connected to the rollers and the roller was connected to belt pully to reduction motor and VFD to control the chain conveyor from inlet to outlet to dry the product at required moisture content.
Correlation studies for seed yield and its components in chickpea (Cicer arientinum L.) germplasm
Authors: Kamble B. G. , Sarode S. B. , Patil M. D. , Akhare M. B. , Gadkar U. G.
Published: March 2024

The association between seed yield and yield contributing characters was studied by using 41 chickpea genotypes. The characters viz. number of pods per plant, 100 seed weight, harvest index, number of secondary branches per plant and plant height recorded a highly positive significant correlation with seed yield at both genotypic and phenotypic levels. This indicates the simultaneous improvement of these characters through selection.
Effect of organic and inorganic sources on economics of hybrid tea rose cv. Gladiator
Authors: Hadwale M. B. , Sable P. B. , Waskar D. P.
Published: March 2024

The present investigation entitled effect of organic and inorganic sources on economics of Hybrid Tea Rose Cv. Gladiator was conducted at Department of Horticulture, Late Shri Vasantrao Naik Marathwada Krishi Vidyapeeth, Parbhani, M.S., India during the year 2008-2009. The experiment was conducted in Randomized Block Design (RBD) with seven treatments and three replications. From the data recorded it was found that the highest returns (Rs. 2.12 Lakhs) were obtained with the treatment T3 (50 % RDF +50% Vermicompost). However, the lowest returns were obtained at the treatment T1 (Control) with 0.92 lakhs. From the data of Benefit : Cost ratio, it was found that the treatment T3 (50% RDF + 50% Vermicompost) was found most beneficial among all the treatments and recorded the highest ratio (1:4.27). However, the lowest ratio (1:2.41) was recorded by the treatment T1 (Control).
Impact of Front Line Demonstrations on the pulses and oilseed productivity in South Tripura district
Authors: Chakraborti Mandira , Singh A.K.
Published: March 2024

Krishi Vigyan Kendra, South Tripura undertaken number of front line demonstration (FLD) to impart knowledge on different improved scientific technologies of non-traditional oilseeds and pulses crops like groundnut, lentil, red gram (arhar) and green gram (moong) during Kharif and Rabi season of 2009-10. To demonstrate the technology, six villages of South Tripura district of Tripura state were selected after assessment of the village through PRA method. Awareness programme were conducted in all villages. Farmers were trained on scientific cultivation practices of groundnut, lentil, red gram (Arhar) and green gram (Moong). Besides imparting training, printed leaflets on oilseed and pulses were distributed among the farmers. Field day programme was also conducted in the farmer’s field during field demonstration. Altogether 8 hectare area of oilseed and 5 ha area of pulses was covered under this programme. Improved varieties of groundnut (GG-20, GG-7 and TG-37A), lentil (WBL-58), green gram (HUM-16) and red gram (UPAS-120) were distributed among the farmers. Under this programme, most of the farmers obtained better yield of pulses and oilseeds as compared to local varieties and traditional method of cultivation. The yield percentage increased from 21.43 to 40 per cent in case of pulses, and 30.43 to 65.45 per cent in oilseed crops. Farmers earned up to Rs.31,100/ha by selling oilseed and up to Rs. 29,250/ha by selling pulses crops. The programme conducted by KVK, South Tripura succeeded to build the skills of farmers for expansion of pulses and oilseeds crops through number of knowledge management practices like group meetings, awareness programmes, trainings, demonstrations, field day, etc. Farmers of the neighbouring villages also participated in this programme and expressed their willingness to take up such crops under scientific methods in the next crop season.