bluuebunny/crossref_metadata_2025 huggingface dataset:
SLC22A3 methylation-mediated gene silencing predicts adverse prognosis in acute myeloid leukemia
Authors: Gu Yu , Xu Zi-jun , Zhou Jing-dong , Lin Jiang , Qian Jun , Wen Xiang-mei , Jin Ye , Yuan Qian , Xia Pei-hui , Feng Yuan , Yang Lei
Published: June 2022

Background: We screened out several hypermethylated solute carrier (SLC) family genes in acute myeloid leukemia (AML) by reduced representation bisulfite sequencing (RRBS). SLC22A3 encodes an organic cation transport protein, which is critical for drug transportation and cellular detoxification. SLC22A3 is significantly downregulated and associated with tumor progression and worse prognosis in a variety of solid tumors. However, there are no data available regarding the role of SLC22A in AML. This study aimed to explore the regulatory mechanism of DNA methylation on SLC22A3 expression, as well as its clinical significance in AML prognosis. Results: SLC22A3 was identified as the sole prognosis-associated gene among SLCs based on TCGA and Beat AML databases. Bone marrow mononuclear cells (BMMNCs) from AML, MDS patients and healthy donors were enrolled in this study. SLC22A3 methylation was significantly increased in AML compared with controls and MDS patients, and meanwhile the expression level of SLC22A3 was decreased. SLC22A3 hypermethylation presented obvious association with some specific clinical characteristics and affected survival time of AML patients as an independent risk indicator. SLC22A3 expression changed regularly as the disease complete remissions and relapses. Demethylation drug 5-aza-2’-deoxycytidine (DAC) activated transcription and increased mRNA expression of SLC22A3 in leukemia cell lines and AML fresh BMMNCs. Knockdown of SLC22A3 in leukemia cells enhanced cell proliferation and suppressed cell apoptosis. Data from public programs were used for auxiliary screening of probable molecular mechanisms of SLC22A3 in antileukemia effect. Conclusions: Our results showed that increased methylation and decreased expression of SLC22A3 may be indicators of poor prognosis in AML. Methylation-silenced SLC22A3 expression may have potential guiding significance on anti-leukemia effect of DAC.
Complete response to pembrolizumab in a patient with recurrent and metastatic urothelial bladder carcinoma reflecting coexisting sarcomatoid subtype and glandular differentiation: a case report
Authors: Miyama Yu , Kanao Kent , Uranishi Kousuke , Hirasaki Masataka , Yasuda Masanori
Published: June 2022

Background: In advanced urothelial carcinoma (UC), approximately 20% of patients respond to pembrolizumab, an anti-programmed cell death-1 (PD-1) antibody. Herein, we reported a single case of UC showing coexistence of sarcomatoid subtype and glandular differentiation. Notably, only glandular differentiation was recurrent, probably progressive, and metastatic, which showed complete response to pembrolizumab.Case presentation: An 80-year-old woman presented with hematuria and dysuria, and an intra-vesical tumor was detected on ultrasound. Transurethral resections (TUR) were performed three times. In the first TUR, a sub-pedunculated tumor and a flat lesion were closely but independently located. Pathologically, the sub-pedunculated tumor was an invasive UC, sarcomatoid subtype. Meanwhile, the flat lesion was invasive UC with glandular differentiation. Despite the second and the additional TUR, the tumor was growing and a lymph node metastasis was detected. The third TUR specimen showed UC with glandular differentiation, and a positive PD-L1 expression as well as high density CD8-positive lymphocytic cells infiltration were observed. Pembrolizumab was administered for four courses after terminating the chemotherapy. The CT scan revealed shrinkage of both primary tumor and metastases. Cystectomy and lymph nodes dissection were performed, and no residual carcinoma was detected. The therapeutic effect was regarded as pathological complete response.Conclusions: Pembrolizumab could be effective for special subtype or divergent differentiation of UC, particularly in an event of an ‘immune hot’ tumor.
Flood Susceptibility Mapping of Internally Displaced Persons Camps in Maiduguri, Borno State Nigeria
Authors: Ogunwumi Taiwo , Njoku Chukwudi , Uzoezie Arinze , Benson Iniobong
Published: June 2022

Increasing climate variability is causing an increase in flood occurrence, affecting vulnerable individuals who have been displaced by the insurgency and conflicts that occurred in the past years. The decade-long insurgency in northeast Nigeria is one of the most pressing humanitarian crises on the continent, with over 2 million people displaced from their homes by conflict and political instability. These yearly floods destroy campsites occupied by displaced families who fled from conflict zones. This study applied the multi-criteria approach, Geographical Information System, and Remote Sensing. Analytical processes such as buffering, slope generation, interpolation, reclassification, and the weighted overlay were performed through the GIS environment to generate a flood susceptibility map indicating four zones (very high, high, low and very low-risk). A total number of 25 of 35 Internal displaced campsites are within the high susceptibility while 4 camps are prone to a Very high flood risk level (SULUMBURI DOGON ICHE, GRA, SULUMBURI CAMP, and FULATARI FARIN RUWA). Based on our results, camps located close to water bodies will be submerged by flood during the coming raining seasons if actions are not taken in time. This paper is a vital for appropriate government agencies such as town planners, emergency management agencies, international NGOs, the United Nations Office for the Coordination of Humanitarian Affairs, and other important stakeholders who can implement preparedness, evacuation planning, and early warning to the populace and Internally displaced individual at various campsite and settlement within the inferred flood risk zones.
Exosome s from ADSCs attenuate bleomycin-induced skin fibrosis and oxidative stress in scleroderma via circ-Zfyve9 delivery
Authors: Zhu Zhidong , Tang Hui , Zhu Yiqi , Wang Hao , Shen Yanyun
Published: June 2022

Background
Systemic sclerosis (SSc) is an autoimmune trait affecting several organs and is identified by thickening of the dermis and connective tissue affected by collagen accumulation, as well as vascular injuries inducing hypoxia.
Methods
In this investigation, adipose-derived stem cells (ADSCs) and their exosomes were separated, and a bleomycin-induced SSc mouse model was constructed. High-throughput sequencing was employed to study abnormal expression of circular RNAs (circRNAs) in SSc skin tissues with or without ADSC exosome treatment. The regulatory mechanism and targets were studied using bioinformatics analysis, luciferase reporting analysis, angiogenic differentiation experiments, and RT-qPCR detection analysis.
Results
In this study, exosomes from ADSCs were successfully isolated. In addition, the exosome treatment prevented dermal thickening and fibrosis in bleomycin-induced scleroderma. In addition, circ-Zfyve9 was demonstrated to have an important function in ADSC exosome-mediated skin tissue protection. GPX4 and miR-135 were shown to be circ-Zfyve9 downstream targets. Overexpressing miR-135 or downregulating GPX4 reversed the promotion effects of circ-Zfyve9 to angiopoiesis by increasing lipidosome ROS in EPCs under hypoxic conditions. Overexpressing miR-135 or downregulating GPX4 reversed the inhibition effect of circ-Zfyve9 on fibrosis in myofibroblasts under hypoxic conditions. Overexpressing circ-Zfyve9 increased the therapeutic effect of ADSC exosomes.
Conclusions
Taken together, the present study results show that the exosomes from ADSCs attenuate bleomycin-induced skin fibrosis and oxidative stress in scleroderma via circ-Zfyve9 delivery.
Ein semi-implizites pseudo-inkompressibles Finite-Volumen Modell zur Simulation diabatischer Atmosphärenprozesse
Authors:   , Schmid Fabienne
Published: June 2022

Atmosphärische Schwerewellen spielen eine wichtige Rolle für die Zirkulation der mittleren Atmosphäre, die wiederum die Troposphäre auf saisonalen und längeren Zeitskalen beeinflusst, und stellen somit ein Schlüsselelement für das Wetter- und Klimageschehen dar. Eine adäquate Beschreibung des Lebenszyklus atmosphärischer Schwerewellen in den operationellen Modellen zur Wettervorhersage und Klimasimulation ist daher sehr wünschenswert. Um zu einer verbesserten mathematischen Darstellung der Schwerewellendynamik in den Modellen beizutragen, wurden in den vergangenen Jahren zahlreiche numerische Studien durchgeführt. Wenngleich auch viele der ablaufenden Prozesse gegenwärtig gut verstanden sind, stellt die Wechselwirkung zwischen den mesoskaligen Schwerewellen und den synoptischskaligen Prozessen aufgrund der hohen Komplexität der Strömung weiterhin eine besondere Herausforderung für die Erforschung der Schwerewellenaktivität dar und erfordert oftmals hochaufgelöste numerische Simulationen über große Modelldomänen. Folglich ist es wichtig, dass die angewendeten numerischen Verfahren effizient sind und möglichst idealisierte, aber dennoch atmosphärenähnliche Szenarien simulieren. In dieser Arbeit wird ein effizientes numerisches Verfahren zur Modellierung der Dynamik interner Schwerewellen sowie deren Einfluss auf die Zirkulation der mittleren Atmosphäre entwickelt. Dabei wird die Diskretisierung des pseudo-inkompressiblen Finite-Volumen-Modells auf einem versetzten Gitter von Rieper et al. (2013), welches der Einfachheit halber Schallwellen aus der Dynamik herausfiltert und zur Untersuchung adiabatischer Atmosphärenprozesse auf der f-Ebene entwickelt wurde, im wesentlichen durch zwei Komponenten erweitert: 1) die Anwendung eines semi-impliziten Zeitschrittverfahrens auf die Bewegungsgleichungen zur Integration der Auftriebs- und Corioliseffekte und 2) die Berücksichtigung einer Heizung durch einen thermischen Relaxationsansatz, welcher in der Troposphäre ein baroklin instabiles Strömungsprofil erzeugt und eine zeitabhängige Dynamik des Hintergrundzustands zulässt. Zur Überprüfung der korrekten Implementierung der Erweiterungen werden eine Reihe von atmosphärischen Standardteststudien durchgeführt, welche die Konvergenzeigenschaften sowie die Effizienz des Verfahrens validieren. Darüber hinaus zeigen die Testfälle, dass die Ergebnisse des Modells mit anderen veröffentlichten Arbeiten sehr gut übereinstimmen. Schließlich wird als Anwendungstestfall eine mesoskalige Simulation barokliner Instabilität in der Troposphäre durchgeführt, welche ferner die darin enthaltene kleinskalige Wellenaktivität sowie deren Einfluss auf die mittlere Atmosphäre modelliert. Die abschließende Betrachung der zonal und zeitlich gemittelten Felder zeigt die erwartete Zonalwindumkehr in der Höhe.
Meaning Properties of Covid-19 Related Terms in Selected Articles
Authors: Chyntia Fita , Deliana Deliana , Mono Umar
Published: June 2022

This study aims to see the meaning properties of the Covid-19 terms in six different articles. By seeing the meaning properties of these Covid-19 terms we can find if the terms are used meaningfully in those articles. The basis of meaning properties include being meaningful or meaningless – they are deemed meaningless if the words used contain ambiguity, redundancy, anomaly, and contradiction. In this study, the qualitative method was used. The sources of data are covid-19 related articles from Google Scholar. The articles chosen are free-accessed articles related to covid-19 impacts, pandemic, and its measures to tackle the crisis. The six covid-19 related articles are read through and the covid-19 related words or phrases that occur more than one time in one article and in more than one article are collected as the data, thirty-eight terms are the result of this data collection. The application of the thirty-eight terms is analyzed by their meaning properties. The result shows there are nine phrases or sentences that are anomalies, five redundancies, and two ambiguities in the original articles. The findings show that even in Google Scholar articles, some of the Covid-19 terms are not used meaningfully in the sentences.
Applications of Choline Chloride-Based Deep Eutectic Solvents as Sustainable Media and Catalyst in the Synthesis of Heterocyclic Scaffolds
Authors: Ratnani Sonia , Bargujar Savita , Khulbe Mihir , Kathuria Abha
Published: June 2022

Deep eutectic solvents (DESs), also referred to as low transition temperature mixtures (LTTMs), have emerged as sustainable and cheap alternatives to conventional organic solvents in organic synthesis. This is attributed to their exceptional characteristics viz. easy preparation with readily available cheap materials, water compatibility, non-flammability, non-toxicity, biocompatibility, biodegradability, etc. All these properties label them as versatile and cost-effective green solvents. The first reported DES, choline chloride urea mixture has appeared as an innocuous solvent and catalyst in many organic transformations. This prospective DES combination has been applied extensively to the synthesis of a wide range of heterocyclic compounds including quinolones, spirooxindoles, etc. The conditions employed are relatively mild and do not require additional acid catalysts or organic solvents. This ecofriendly blend for the synthesis of heterocycles reports excellent yields of products with shorter reaction times and a simple workup procedure. Evaluating these merits, this review focuses on the recent literature published on the use of choline chloride-based DESs in the synthesis of a few important heterocyclic compounds.
A Network Pharmacology Study on the Similarities and Differences in the
Mechanisms of Zuo Gui Wan/You Gui Wan for the Treatment of
Premature Ovarian Failure
Authors: Mei Shanshan , Yu Chaoqin , Ding Jie , Cheng Wen
Published: June 2022

Background:

Premature ovarian failure is a heterogeneous disease that severely affects the quality of life of women in their reproductive years. The ancient classical Chinese medicine compounds Zuo Gui Wan and You Gui Wan have great potential to treat premature ovarian failure, but the similarities and differences in their pharmacological mechanisms for treating POF are not yet clear.

Method:

In this study, the public database was used to screen the active ingredients and potential targets of Zuo Gui Wan and You Gui Wan. The similarities and differences in the potential targets of both pills for the treatment of POF were analysed using the POF-related genes obtained from OMIM and GeneCards. The protein–protein interaction network was established and collated to form a drug-active ingredient-target gene network by using STRING. Finally, the drug–target–pathway network was constructed by enrichment analysis to find the differences in target enrichment on the same pathway.

Results:

Pharmacological analysis of the network showed that Zuo Gui Wan contains 72 active ingredients, While You Gui Wan has 112. A total of 62 common compositions, such as quercetin and kaempferol, were identified. Amongst them were 10 unique compounds, such as hydroxyproline and cholesterol, in Zuo Gui Wan and 50 exclusive compounds, such as Karanjin and beta-carotene, in You Gui Wan. In addition, 14 overlapping targets, including MAPK1, CXCL8, TNF, IL6, and EGFR, were determined amongst the first 20 targets in the treatment of POF by both pills, demonstrating that the core mechanism of POF treatment is similar between the two. Pathway enrichment analysis showed 87 identical and significant pathways between Zuo Gui Wan and You Gui Wan, including IL-17, TNF, PI3K-Akt, oestrogen, VEGF, and other pathways. Zuo Gui Wan has 12 special pathways, such as natural killer cell-mediated cytotoxicity and intestinal immune network for IgA production. You Gui Wan has nine unique pathways, such as insulin secretion and glucagon signalling pathway.

Conclusion:

Zuo Gui Wan and You Gui Wan could treat POF by inhibiting oxidative stress and inflammation, regulating hormone levels, improving ovarian function, and promoting follicular development. Zuo Gui Wan is inclined to immune regulation, While You Gui Wan prefers insulin regulation. Therefore, similarities and differences clearly exist in the specific mechanisms of Zuo Gui Wan and You Gui Wan in the treatment of POF.
An Insight into the Hepatoprotective Activity and Structure-activity Relationships
of Flavonoids
Authors: Majee Chandana , Mazumder Rupa , Choudhary Alka N. , Salahuddin
Published: June 2022

Background:

Flavonoids are a class of polyphenolic bioactive compounds obtained from plants, which have a wide range of chemical structures and properties. More than 9000 distinct flavonoid molecules have been identified, and have been found to regulate numerous developmental processes and play key biological roles in living organism.

Objective:

This review aims to highlight the hepatoprotective potentiality of flavonoids and co-relate their pharmacological activity with their chemical structure.

Methods:

With advancement in the field of research related to phytochemicals, it is evident that flavonoids have versatile health benefits, viz., antioxidant property, free radical scavenging capacity, anticancer activity. The basic structures are C6—C3—C6 rings with various substitution patterns, resulting in a succession of subclass compounds, and the relationships between chemical structures and bioactivity have previously been investigated.

Results:

The hepatoprotective effects of bioactive flavonoids derived from plants have been widely linked to their antioxidant activity, antiinflammatory activity, effects on sterol regulatory element-binding proteins (SREBP), peroxisome proliferator-activated receptor gamma (PPARγ) receptors, and inflammatory mediator cytokines according to numerous studies. The C2-C3 double bond at the A ring, as well as the hydroxyl groups of C3′or C4′, and the carbonyl group at position C4,have been shown to augment their hepatoprotective activities; however, hydroxymethylation at C3′ and C4′ has been found to diminish the hepatoprotective activity.

Conclusion:

The impact of flavonoid moieties and the structure-activity relationship of flavonoids related to combating various hepatic disorders have been vividly discussed in this review paper.
A Role of Thyroid Hormones in Acute Myocardial Infarction: An Update
Authors: Jafar Tassadaq Hussain , Rasool Rabia , Unar Ahsanullah , Chanihoon Ghulam Qadir , Mubeen Bismillah
Published: June 2022

The acute coronary syndrome is one of the commonest life-threatening illnesses. It encompasses
the clinical spectrum of acute myocardial ischemia and includes unstable angina and
acute myocardial infarction both with and without ST segment elevation. The acute coronary syndrome
can be attributed to a significant hemodynamic insult that leads to atherosclerosis of the epicardial
coronary arteries. The main causative risk factors, such as obesity, smoking, and alcohol
intake, increase the burden of acute coronary syndrome. Owing to an increase in the utilization of
antioxidants, the antioxidant capacity decreases concerning the scavenging of lipid peroxides.
Moreover, the thyroid hormones are important regulators of the expression of cardiac genes, and
many of the cardiac manifestations of thyroid dysfunction are associated with alterations in triiodothyronine-
mediated gene expression. Cardiovascular signs and symptoms of thyroid disease are
among the most acute clinically relevant findings that occur in combination with both hypothyroidism
and hyperthyroidism. By understanding the cellular mechanism of the action of thyroid hormones
on the heart and cardiovascular system, it is possible to explain rhythm disturbances and alterations
in cardiac output, blood pressure, cardiac contractility, and vascular resistance that result
from thyroid dysfunction. Oxidative stress is thereby induced, together with a decrease in antioxidant
capacity for overcoming oxidative stress, which leads to endothelial dysfunction, subsequent
atherosclerosis, and, ultimately, acute myocardial infarction. The implications for the identification
of the effects of thyroid disease on acute myocardial infarction include the observation that restoration
of normal thyroid function repeatedly reverses abnormalities in cardiovascular hemodynamics.
Jugular Paraganglioma Presenting with a Tumor Thrombus Extending
from Posterior Fossa to Right Atrium and Multiple Skeletal Metastases
Authors: Pehlivan Umur Anil , Oktay Kadir , Onan Hasan Bilen , Acikalin Arbil , Keser Celalet , Paydas Semra
Published: June 2022

Introduction:

Paragangliomas are tumors of neuroendocrine origin, may appear in different
localizations, and are related to the autonomic nervous system. Paragangliomas are generally asymptomatic
and may rarely appear with adrenergic symptoms, and clinical findings depend on the catecholamines
they secrete. Extra-adrenal paragangliomas are mostly benign, like all paragangliomas.
Malignancy criteria consist of local recurrence, metastasis after total resection, and presence of distant
metastasis during primary diagnosis.

Case Presentation:

This report presents the case of a 31-year-old man with jugular paraganglioma,
multiple skeletal metastases, and a long-segment tumor thrombus. Imaging procedures showed a continuous
tumor thrombus extending from the posterior fossa to the right atrium and metastases in C2,
T1, T6, T8, L5, and right humerus. Histopathological assessment of the metastasis in C2 identified
malignant paraganglioma. Curative surgery was not an option for this patient, hence combined chemotherapy
was given.

Conclusion:

In cases of malignant paraganglioma with multiple distant metastases, chemotherapy and
radiotherapy are feasible treatment methods.
Heterogeneous Photocatalysis using Electroless Deposition of Ni/NiO
Nanoparticles on Silicon Nanowires for the Degradation of Methyl Orange
Authors: de Jesús Pérez Bueno José , López Maria Luisa Mendoza , Jesús Betancourt Medina Martin de , Rodríguez Carlos Hernández , Maldonado Pérez Alejandra Xochitl , Bocarando Chacón Jacqueline Guadalupe , López Coraquetzali Magdaleno , Robles María Reina García , Oza Goldie
Published: June 2022

Aims:

This work uses the MACE method to synthesize SiNWs- NiNPs/NiONPs to degrade organic pollutants by photocatalysis.

Background:

Photocatalytic degradation has been applied as an attractive solution to remove several organic pollutants. Heterostructured nanomaterials have become an interesting platform for investigation. Metal-assisted chemical etching (MACE) stands out as a promising technique because it is simple, low cost, and fast.

Objective:

Attain the degradation of methyl orange (MO) in the presence of silicon nanowires (SiNWs) in heterojunction with Nickel/Nickel Oxide nanoparticles (NiNPs-NiONPs).

Methods:

SiNWs were synthesized by metal (Ag) assisted chemical etching (MACE) of monocrystalline silicon wafers. NiNPs were non-electrolytically deposited on the SiNWs (electroless method). The morphology of the SiNWs- NiNPs/NiONPs was observed by SEM.

Results:

Heterogeneous photocatalytic degradation of methyl orange (C14H14N3NaO3S) in an aqueous solution at a concentration of 20 ppm had an efficiency of 66.5% after 180 min under UV irradiation. The MO degradation percentage was determined using UV-visible spectrophotometry.

Conclusion:

The SiNWs-NiNPs/NiONPs were obtained composed mainly of Si covered by SiO2 decorated on the tips with Ni (II) in the form of NiO and a small amount of nickel metal. The removal efficiency obtained at 180 min of light exposure was 66.5%. After the photocatalysis tests, further oxidation of the NiNPS into NiONPS, was attributed to the reactive oxygen species in the aqueous medium based on the changes of the oxygen and Ni2p3/2 peaks by XPS.

Other:

Through XPS, the oxidation state of the SiNWs- NiNPs/NiONPs was analyzed.
Alcoholic Consumption of Young Italians During the SARS-CoV-2
Pandemic
Authors: Federico Alessandro , Mazzarella Chiara , Spina Annamaria , Dallio Marcello , Romeo Mario , Masarone Mario , Persico Marcello , Gravina Antonietta Gerarda , Luzza Francesco , Abenavoli Ludovico , Di Mauro Maurizio , Loguercio Carmelina
Published: June 2022

Background:

The international health emergency caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which, at the end of 2019, hit the world, forced the govern-ments of all countries to adopt stringent restrictive measures to contain the spread of the virus. Sever-al studies have revealed worsening levels of anxiety, depression and perceived stress related to these restrictions and the resulting lifestyle changes. Some studies have also confirmed the presence of a re-lationship between SARS-CoV-2-related emotional distress and drinking behavior. Indeed, is a well-known fact that alcohol consumption is one of the behavioral strategies used to reduce negative emo-tional states. However, it was documented that young people developed different responses to alcohol use during the pandemic than adults.

Objective:

The aim of this work was to investigate the consumption habits of young Italians and how the consumption and purchase of alcoholic beverages have changed following the pandemic. New ways of drinking alcohol were also interesting to observe, such as online.

Methods:

Young people between 18 and 35 years old were subjected to an anonymous questionnaire of 22 questions on the adoption of forms of behavior at risk through alcohol consumption, the quanti-ty and occasions of preferential consumption, and on the methods and quantities of alcoholic bever-age purchase, before and during the SARS-CoV-2 pandemic. The subjects who declared themselves "non-drinkers" were not included in the statistical survey.

Results:

About 33% of the enrolled "drinkers" (268/823), adopted risky forms of alcoholic behavior. Males reported a higher average habit of drinking wine or alcohol (M = 1.9953 ± 1.39743, F = 1.7373 ± 1.36688, p <0.005); an increased frequency of drinking (M = 2.3025 ± 0.80610 F = 2.0494 ± 0.75043 p <0.001); a higher average number of drinks consumed (M = 1.5182 ± 0.85646, F = 1.2618 ± 0.53292, p <0.001) and binge drinking to the greatest extent (M = 1.1933 ± 0.96522 F = 0.8176 ± 0.85446 p <0.001). Education and employment were significantly correlated with the frequency of al-cohol consumption (r = 0.107 p <0.005 and r = 0.120 p = 0.001 respectively). Subjects reported buy-ing alcoholic beverages during the pandemic with a frequency of "less than once a month" (N = 291, 35.36%) and mainly in shops (N = 556, 67.56%), while before the pandemic they mainly bought al-cohol once a week (N = 431, 52.37%) and predominantly in bars / clubs (N = 619, 75.21%). New ways of drinking alcohol such as online drinking, have not been significantly identified.

Conclusion:

A change in alcohol consumed and alcohol purchased before and during the SARS-CoV-2 pandemic was revealed.
Berberine Hydrochloride Embedded Chitosan-based Novel Floating Microspheres:
Optimization, Characterization, and in vivo Anti-ulcer Potential
Authors: Kumar Manish , Rani Radha , Verma Ravinder , Gupta Pravin , Kumari Beena , Pahwa Rakesh , Mittal Vineet , Bhatt Shailendra , Kaushik Deepak
Published: June 2022

Background:

Microspheres are controlled drug delivery systems (CDDS) because they have the potential to encapsulate various drugs, nucleic acids, and proteins. Their benefits include biocompatiblity, greater bioavailability, and controlled release. Presently, existing antiulcer agents suffer from severe side effects which restricted their utility and encouraged the requirement of a harmless and proficient new antiulcer agent. The rationale of the present research work was to absorb the drug in the stomach for better antiulcer potential and fewer side effects.

Objective:

The rationale of the current investigational effort is to prepare and examine floating microspheres using berberine hydrochloride to increase gastric retention without interaction with the mucosa inside the stomach.

Methods:

The capillary extrusion technique was used with the aid of chitosan, a polymer in addition to sodium lauryl sulphate, a crosslinking agent. Scanning electron microscopy characterized the surface morphology of the prepared microspheres. The effects of polymeric concentration as well as the concentration of cross-link agent on percent yield, in vitro floating behavior, and in vitro drug release were efficiently assessed.

Results:

Diffusion has been observed as a popular mechanism for most launches. Prolonged drug release (12 hrs) has been seen in the prepared microspheres and they also remained buoyant for around 10 hrs. In vivo evaluation study was successfully performed. From the values of ulcer indexes for various groups, percentage protection was determined. The treatment group (F-2 formulation) showed the maximum percentage protection of 97.29%.

Conclusion:

The prepared floating microspheres can thus persuade potential candidates to be adaptable to any intra-gastric conditions for multiple-unit delivery devices.
Implementasi Kebijakan PBB Perdesaan dan Perkotaan di Provinsi DKI Jakarta
Authors: Pamungkas Yusuf Agil , Satispi Evi
Published: June 2022

Dengan berlakunya Undang-Undang Nomor 28 Tahun 2009 tentang Pajak Daerah dan Retribusi Daerah mengamanatkan adanya penyerahan kebijakan Pajak Bumi Bangunan Perdesaan dan Perkotaan (PBB-P2) kepada Pemerintah Daerah. Dalam prakteknya, terdapat basis data objek pajak yang bermasalah, diantaranya penetapan ganda atas satu objek pajak. Tujuan dari pelaksanaan penelitian adalah menganalisis implementasi kebijakan PBB-P2 di Provinsi DKI Jakarta. Metode penelitian yang digunakan adalah deskriptif kualitatif. Proses pengumpulan data dalam penelitian ini menggunakan teknik observasi, dokumentasi dan wawancara. Hasil penelitian menunjukkan bahwa pelaksanaan kebijakan PBB-P2 di Provinsi DKI Jakarta sejalan dengan Teori Edwards III dimana dipengaruhi oleh faktor komunikasi, sumber daya, disposisi dan struktur birokrasi. Hal ini terlihat dari kejelasan dan konsistensi pimpinan dalam mentransmisikan tujuan dan sasaran kebijakan kepada para pelaksana. Sumber daya manusia dan keuangan yang dialokasikan untuk mendukung kebijakan PBB-P2 masih terbatas, sehingga menghambat proses validasi basis data pajak. Pelaksana memiliki integritas, komitmen dan rasa tanggung jawab yang baik untuk menjalankan kebijakan yang telah ditetapkan. Struktur birokrasi telah menggambarkan dengan jelas adanya pemisahan tugas dan fungsi antar pelaksana.
The effect of genre and tarosi snake and ladders education media on reproductive health knowledge of adolescent in Karangsari Pengasih Village, Kulon Progo, Yogyakarta
Authors: Cahyani Nesti Nur , Fatimah Fatimah , Yulitasari Brune Indah
Published: June 2022

Background: Reproductive health is a state of physical, mental, and social well-being in all aspects related to the system and its functions and processes. The impact of reproductive health disorders is the occurrence of unwanted pregnancies, transmission of sexually transmitted diseases, and the use of drugs.

Objective: This study was to determine the effect of the tarosi genre and educational media on the knowledge of adolescent reproductive health in Karangsari Pengasih Village, Kulon Progo, Yogyakarta.

Methods: This type of research is pre-experimental with a one-group pre-posttest design. This research was conducted in Karangsari Pengasih Village, Kulon Progo, with a population of 400 teenagers. The sample of this research is 20 respondents. Bivariate analysis was conducted on the influence of educational media for snakes and ladders Genre and Tarosi on adolescent reproductive health knowledge using Paired t-test for paired samples.

Results: This study shows that the level of knowledge of adolescents about reproductive health using Tarosi education media is greater than those using Media Genre, namely the average pre-test score is 11.80 and post-test is 16.40. Moreover, the two media have the same influence on the level of knowledge of reproductive health in adolescents. This can be shown by the results of the significance value of the two media of 0.000˂p 0.05.

Conclusion: This study concludes that there is an influence of the tarosi genre and educational media on the knowledge of reproductive health in adolescents in Karangsari Pengasih Village, Kulon Progo Yogyakarta.
The effect of 3 months contraceptive injection on the body mass index of women of reproductive age in the Midwifery Independent Practice of Central Jakarta
Authors: Hamidah Hamidah , Damayanti Dina Sulviana
Published: June 2022

Background: Obesity is increasing in almost all countries in the world and becomes big challenge for the world of health at the moment because it can cause chronic health problems. The increase of obesity occurred is related to the lifestyle of each individual along with the present pandemic condition which carries several consequences caused by change from active behavior into relaxed or sedentary behavior. Because of side effects of weight gain during the use of contraceptive and pandemic routines that change activities, Women of reproductive age gain fat excessively and even lead to obesity.  

Objectives: The independent variable in this study was hormonal contraceptive (DMPA) and the dependent variables were obesity, age, and duration of hormonal contraceptive (DMPA). The data collected will be tested for normality in advance in order to discover whether the data are normally distributed or not, then will be analyzed by using simple linear regression. This study is expected to provide a reference to suppress obesity in women of reproductive age so the quality of life and reproductive system can be maintained and can bear healthy descendants.

Methods: This study had been performed by a quantitative method with chi-square analysis in order to discover the occurrence of obesity with total samples of 385 acceptors of contraceptive in Midwifery Independent Practice in Central Jakarta.  

Results: The results obtained had indicated that there was no effect on using 3 months contraceptive injection with the occurrence of obesity (p-value = 0.174), and there was no relationship between the duration of using 3 months contraceptive injection and the occurrence of obesity (p-value = 0.467). However significant results were obtained between the age and the occurrence of obesity in acceptors of 3 months contraceptive injection (p-value = 0.013) with a value = 0.05.
Conclusions: Women of reproductive age who use 3 months contraceptive injection were expected to be able to maintain their quality of life by preventing excessive weight gain by doing physical activities that can burn calories although it can only be done at home or environment around the house, and doing productive activities during the present COVID-19 pandemic.
Hydrocolloids reduce nasal injuries in infants receiving CPAP: a systematic review
Authors: Ngaisah Siti Nur , Rustinah Yeni
Published: June 2022

Background: CPAP is the standard oxygenation management in the respiratory emergencies in infants, complications such as nose injuries are still common. Recognizing risk factors and reducing the pressure which created between the adhesive interface and the nasal skin surface can prevent this complication

Objectives: The aims of this literature review is to determine the benefits of hydrocolloid dressing on nasal injury and comfort in infants with CPAP.

Methods: Systematic review, the articles search involved several online databases based on the PICO framework and focused on using PRISMA.

Results: 9 articles found according to the criteria. There are 3 main themes such as risk factors, the type of interface and  barriers skin

Conclusions: nasal injury can be prevented by selecting the right interface and administering hydrocolloid as a barrier to reduces pressure at the interface.
The risk sexual behavior of adolescents reviewed based on Health belief model
Authors: Ningrum Puspita
Published: June 2022

ABSTRACT

Background: Sexual behavior is a form of behavior that is carried out to attract attention with the opposite sex and involves a touch on the limbs carried out between men or women so that they reach the stage of intimate relationships. Health belief model (HBM) is one of the patterns in determining the relationship between health beliefs and behavior. The behavior of adolescents who have sexual relations is reviewed using the Health Belief Model theory because it can predict and influence the possibility that adolescents can prevent or not believe in the individual's own beliefs.

Objectives: To analyze how the relationship between perceived susceptibility, perceived seriousness, perceived benefits, perceived barriers, self-efficacy and cues to action with adolescent sexual behavior based on the Health Belief Model

Methods: This study is a non-experimental study using a cross-sectional approach. The sample in this study were 300 respondents who were conducted at SMA X Kotamobagu by taking purposive sampling technique. The instrument used is a questionnaire. Statistical test using Pearson Product Moment with a=<0.05

Results: The majority of respondents showed less behavior as much as 148 (49.3%), the majority of respondents were 17 years old (30.0%), the majority of female respondents were 204 (68.0%). The results of the analysis showed that there was a relationship between perceived susceptibility, perceived barriers, self-efficacy, cues to action p=<0.05 with risky sexual behavior, there was no relationship between perceived seriousness and perceived benefits adolescent with risky sexual behavior.

Conclusions: Based on the results of the analysis there is a relationship between perceived susceptibility, perceived barriers, self-efficacy, cues to action with risky sexual behavior p=<0.05, there is no relationship between perceived seriousness and perceived benefits with adolescent risky sexual behavior, the most related variable is cues to action at SMA X Kotamobagu

 
Correction: Predictors of Health Information–Seeking Behavior: Systematic Literature Review and Network Analysis (Preprint)
Authors: Mirzaei Ardalan , Aslani Parisa , Luca Edward Joseph , Schneider Carl Richard
Published: June 2022

UNSTRUCTURED

NA
Perceived Effectiveness of COVID-19 Preventive Practices and Behavioral Intention: Survey of a Representative Adult Sample in the United States (Preprint)
Authors: Bagasra Anisah , Allen Christopher T , Doan Sara
Published: June 2022

BACKGROUND

Using existing models of behavioral health promotion, specifically the Extended Parallel Process Model, previous research has identified factors that may impact engagement in preventive health behaviors during the COVID-19 pandemic such as perceived threat, perceived susceptibility to the threat, perceived severity, and perceived efficacy.

OBJECTIVE

This study aims to examine the role of perceived effectiveness of COVID-19 preventive behaviors, perceived susceptibility, perceived threat, and perceived severity of COVID-19 in participants’ intentions to engage in Centers for Disease Control (CDC)–recommended individual health behaviors in the first year of the pandemic.

METHODS

In October 2020, a representative sample of 506 US adults completed a web-based survey through the RAND American Life Panel.

RESULTS

The study primarily found that participants who perceived that CDC-recommended health practices were effective had stronger intentions to engage in those practices. The second strongest correlate was participants’ perceived severity of COVID-19 across the United States. Perceived effectiveness of recommended practices accounted for the largest variance in behavioral intention. However, analysis of individual behaviors indicated a mismatch in the behaviors perceived to be the most effective (avoiding sick people and mask-wearing) and those participants indicated intention to engage in (throwing away used tissues, avoiding sick people, and coughing into their elbows) in the next 30 days.

CONCLUSIONS

The authors recommend tailoring public health messaging to address the perceived threat of COVID-19 and self-efficacy. Thus, health promotion efforts should emphasize the effectiveness of CDC-recommended practices while highlighting the pandemic’s severity. Additionally, rebuilding trust in public health messaging and messengers is necessary to increase perceived self-efficacy. As the COVID-19 pandemic continues, health messaging must continue to promote and build trust in CDC-recommended health practices and educate regarding the efficacy of vaccination and other preventive behaviors.

CLINICALTRIAL
Working mechanisms of a Virtual Reality Exposure Therapy (VRET) for Symptoms of Claustrophobia: A Mixed-Methods Study with Patients, Healthy Subjects and Therapeutic Experts (Preprint)
Authors: Mayer Gwendolyn , Gronewold Nadine , Polte Kirsten , Hummel Svenja , Barniske Joshua , Korbel Jakob Johannes , Zarnekow Rüdiger , Schultz Jobst-Hendrik
Published: June 2022

BACKGROUND

The effectiveness of virtual reality exposure therapy (VRET) in the treatment of anxiety disorders is well established. Several working mechanisms of VRET have been identified, whereby both emotional processing and the sense of presence play a key role. However, there are only few studies that contribute to our knowledge on the working mechanisms in the case of VRET for claustrophobia.

OBJECTIVE

The current study asks for the experiences and perspectives of patients, healthy subjects and therapeutic experts testing a VRET application with 5 intensity levels for symptoms of claustrophobia in order to detect working mechanisms and find suggestions for improvement.

METHODS

A mixed-methods design was applied in which patients (n=15), healthy subjects (n=15) and therapeutic experts (n=15) tested a VRET intervention of an elevator ride in 5 intensity levels. Intensity was varied by elevator-size, duration of elevator-ride, and presence of avatars. Quantitative measures examined pre-treatment state-anxiety (STAI-S), the technology commitment scale (TCS) and post-treatment self-reported presence with the igroup presence questionnaire (IPQ). Finally, a quality score was calculated on the basis of 15 Likert-scaled evaluation items that had been developed for the purpose of this study ranging from 0 to 5. Think-aloud protocols of the patients and semi-structured interviews post-treatment of all participants were conducted to gain in-depth perspectives on emotional processes.

RESULTS

Pre-treatment anxiety was highest in the patient group with a STAI-S score of M=45.79 (healthy subjects: M=35.47; experts: M=36.80). Technology commitment was M=4.02 among all participants. Post-treatment scores showed a high IPQ presence score (M=3.88, SD=0.90) with differences between the three groups (P=.03*), especially lower values for patients (M=3.77, SD=0.91). Overall evaluation was high with M=4.24 (SD=0.35). The think-aloud protocols of the patients revealed that anxiety and presence both were achieved. Qualitative interviews uncovered 8 topics including feelings & emotions, personal story, telepresence, therapeutic effects, barriers, conditions and requirements, future prospects and realization.

CONCLUSIONS

The VRET intervention for claustrophobia evoked anxiety in patients and tension in the controls. A feeling of presence was reported by all participants. Patients expressed to prefer the presence of a therapist while doing the intervention. Experts rated the intervention as clinically valuable. Due to the implementation of avatars some of the fears might be related to symptoms of social phobia or agoraphobia. A higher degree of sophistication in the intensity levels is needed to deliver targeted help for specific symptoms of anxiety.
Landscape of Digital Peer Support Services During COVID-19 (Preprint)
Authors: Fortuna Karen , Chalker Samantha , Ferron Joelle
Published: June 2022

BACKGROUND

Social distancing and lockdown measures due to the COVID-19 pandemic has transformed the delivery of mental health care from in-person to remote services supported through the use of technologies. When the COVID-19 pandemic lockdown measures were instituted, wide scale necessity for remote mental health care emerged not only for professional clinicians, such as psychiatrists, psychologist, and social workers, but also certified peer support specialists. Understanding the landscape of digital peer support services can facilitate community-based support services to assist patients’ in coping with mental health symptoms between clinical encounters with licensed professionals.

OBJECTIVE

The objective of this cross-sectional study, is to describe the landscape of digital peer support within the United States.

METHODS

A national online survey was developed with input from certified peer specialists and completed by peer support specialists.

RESULTS

The majority of certified peer support specialists were trained in digital peer support. Most certified peer support specialists services were delivered through phone calls (62.1%), videoconference (54.6%), text (42%), video-conference based services (64.5%), smartphone-based communication (53%), smartphone applications (15.3%) and social media (47%). Some emerging digital peer support services were offered through virtual reality (2.4%) and video games (1.3%). Of the smartphone applications mentioned, 3% targeted connection making, 4% targeted alcohol or cigarette use, and 5% targeted meditation and mindfulness.

CONCLUSIONS

The majority of certified peer support specialists were trained in digital peer support, and the majority of services were delivered via telephone calls, videoconference-based services, and text messages. However, certified peer specialists offered peer support through smartphones and social media as well as virtual reality and video games. Virtual reality and video games may represent emerging technologies to develop and deliver community-based supports. The majority of certified peer support specialists use popular, publicly available technologies, rather than specific evidence-based mental health technologies. Using readily available, popular technology between clinical encounters may increase the uptake of support service between encounters and support delivery of digital peer support.
Understanding the Difficulties of Building Intersubjectivity among Members of an Organization
Authors: Hom Donna
Published: June 2022

The power of an organization comes from its members and it is the commitment of developing an intersubjective, experience with other members that nukes the administration functional. To translate the intersubjectively concept to life, it can he interpreted as follows: to be a member of an organization is to think and act in a certain way. of particular goals, values, pictures of the world, and to think and art so as to belong to an organization. In reali organization members have diversified backgrounds & cultural, sexual, educational, ethnic, and age – there are in building an intersubjective undemanding. To name a few, not recognizing the need for nor being willing to build intersubjectivity, lack of trust among members, lack of complete information when constructing intersub- ambiguity of language, cultural differences among members of an organization, action being different from words, recognition of changing condition, and valuing efficiency over long-term committment. Some tools, such as action can be used to overcome these difficulties. Action skills can be acquired through continuous education.
Government matters More Than Ever: Toward Respect for Government in an Increasingly Privatized World
Authors: Hamilton Mary R.
Published: June 2022

This article argues that, in our rapidly changing, increasingly complex worId, govemment matters. It always has and arguably now matters more than ever largely because of the context within which we live — a context in which more than two decades of govemment bashing have taken their toll on pride and capacity in public service, leaving an emusculaled public actor to deal with the immense challenges of today's world. To make this argument the historical shifts of perspecitve on government and the marketplace are describe along with the changes occurring so rapidly in our world. Second, the impact of the recent shift to a pro-marketplace bias and the impacts of globalization. interdependence and increased tribulism on governments and on public administration are described. Finally, some key challenges facing public administration as a result of these changes are discussed.