bluuebunny/crossref_metadata_2025 huggingface dataset:
Knockdown lncRNA Neat1 regulates the activation of microglia and alleviate neuronal apoptosis through AKT/STAT3 pathway after cerebral ischemic reperfusion.
Authors: Ni Xunran , Su Qian , Xia Wenbo , Zhang Yanli , Jia Kejuan , Li Guozhong , Su Zhiqiang
Published: February 2020

Background Acute cerebral ischemia may cause serious consequences, one of them is brain injury caused by the uncontrolled reperfusion which occurs once the circulation is re-established. Neat1 is one of long non-coding RNA presents important roles in the immune system. However, the potential roles and underlying molecular mechanisms of it in cerebral ischemic reperfusion injury is still unclear.The aim of the present study was to investigate the function of LncRNA Neat1 in cerebral ischemic reperfusion injury and its possible advantage for neure.MethodsIn our study, oxygen glucose deprivation was used in vitro to mimic cerebral I/R injury. CCK8 was used to mesure cell viability and flow cytometry measured cell apoptosis. qRT-pcr was used to measure the phenotypic marker of M1 and M2 microglia, western blot was used to detect the protein expression of AKT/STAT3 pathway.ResultsKnockdown the LncRNA Neat1 alleviated the apoptosis induced by OGD/R and increased the cell viability.We further provided that Neat1 may inhibite microglia polarize to M1 phenotype to reduce the damage of immunoreaction caused after cerebral I/R injury through AKT/STAT3 pathway. ConclusionsWe evaluated the function and mechanism of lncRNA Neat1 in cerebral I/R injury, And LncRNA Neat1 may be a potential target for new therapeutic intervention.
Effectiveness of recombinant Escherichia coli for the production of (R)-(+)-perillyl alcohol ﻿
Authors: Sun Chao , Dong Xianjuan , Zhang Rubing , Xie Congxia
Published: February 2020

Background:(R)-(+)-perillyl alcohol is a naturally oxygenated monoterpene that is produced in perilla leaves, citrus, lemon and lavender. Perillyl alcohols have many uses, including natural flavor additives, insecticides, jet fuels and anti-cancer therapies. The bioconversion of readily available monoterpene precursors, such as (R)-(+)-limonene are recognized as valuable oxygenated derivatives. However, as this natural product is present at low concentrations in plant oils, alternative microbial production methods are required for its extraction from natural plant sources. Results:In this study, we engineered Escherichia coli to possess a heterologous mevalonate (MVA) pathway, including limonene synthase, P-cymene monoxygenase hydroxylase and P-cymene monoxygenase reductase for the production of (R)-(+)-perillyl alcohol. The concentration of (R)-(+)-limonene (the monoterpene precursor to (R)-(+)-perillyl alcohol) reached 27.3 mg/L from glucose. Enhanced (R)-(+)-perillyl alcohol production was therefore achieved. The strain produced (R)-(+)-perillyl alcohol at a titer of 45.7 mg/L in a 5 L bioreactor fed batch system. Conclusions:These data highlight the efficient production of (R)-(+)-perillyl alcohol through microbial fermentation. This can serve as a platform for the future production of other monoterpenes.
Gender-Based Vulnerability: Combining Pareto ranking and geostatistics to model gender-based vulnerability in Rohingya refugee settlements in Bangladesh
Authors: Nelson Erica , Saade Daniela Reyes , Greenough P.Gregg
Published: February 2020

Background: The Rohingya refugee crisis in Bangladesh continues to outstrip humanitarian resources and undermine the health and security of over 900,000 people. Spatial, sector-specific information is required to better understand the needs of vulnerable populations, such as women and girls, and to target interventions with improved efficiency and effectiveness. This study aimed to create a gender-based vulnerability index and explore the geospatial and thematic variations in gender-based vulnerability of Rohingya refugees residing in Bangladesh by utilizing pre-existing, open source data. Methods: Data sources included remotely-sensed REACH data on humanitarian infrastructure, United Nations Population Fund resource availability data, and the Needs and Population Monitoring Survey conducted by the International Organization for Migration in October 2017. Data gaps were addressed through probabilistic interpolation. A vulnerability index was designed through a process of literature review, variable selection and thematic grouping, normalization, and scorecard creation, and Pareto ranking was employed to rank sites based on vulnerability scoring. Spatial autocorrelation of vulnerability was analyzed with the Global and Anselin Local Moran’s I applied to both combined vulnerability index rank and disaggregated thematic ranking. Results: Twenty-four point one percent of settlements were ranked as ‘most vulnerable,’ with 30 highly vulnerable clusters identified predominantly in the upazila of Sadar. Five settlements in Dhokkin, Somitapara, and Pahartoli were categorized as less vulnerable outliers amongst highly vulnerable neighboring sites. Security- and health-related variables appear to be the most significant drivers of gender-specific vulnerability in Cox’s Bazar. Clusters of low security and education vulnerability measures are shown near Kutupalong. Conclusion: The humanitarian sector produces tremendous amounts of data that can be analyzed with spatial statistics to improve research targeting and programmatic intervention. The critical utilization of these data and the validation of vulnerability indexes are required to improve the international response to the global refugee crisis. This study presents a novel methodology that can be utilized to not only spatially characterize gender-based vulnerability in refugee populations, but can also be calibrated to identify and serve other vulnerable populations during crises.
A classroom intervention targeting working memory, attention and language skills: a cluster randomised feasibility trial
Authors: Rowe Anita , Titterington Jill , Holmes Joni , Henry Lucy , Taggart Laurence
Published: February 2020

Background: International debate around the best models of speech and language therapy provision for children with language disorders has highlighted the need for research into classroom-based approaches and intervention dosage. Working memory (WM) is a cognitive skill that underpins attention and language. ‘Recall to Enhance Children’s Attention, Language and Learning’ (RECALL) is a novel, six-week, classroom-based intervention targeting WM to enhance attention and language skills in 4-5 year olds.Methods : A cluster randomised feasibility trial was conducted to address uncertainties around: the feasibility of a definitive trial to evaluate RECALL; the acceptability of RECALL to the health professionals and teachers who would deliver it; and the factors that may impact on the fidelity of its delivery in the classroom. Six classes of 4-5 year olds participated: 2 received RECALL; 2 received an existing intervention targeting attention skills (not underpinned by WM theory); and 2 received education as usual (no intervention). Ten children in each class ( n= 60) were sampled to assess the appropriateness of the outcome measures that may be used in a definitive trial. A process evaluation included: observations of the fidelity of the intervention delivery and semi-structured interviews with the health professionals (HPs) and teachers who delivered RECALL.Results: The recruitment targets were achieved and all six schools completed the trial. For the experimental RECALL intervention, 95% of sessions were delivered but fidelity to the intervention protocol varied between the two schools (76% versus 45%). The interview data revealed mixed findings regarding the acceptability of the intervention tasks and the outcome measures. A greater understanding of the theory underpinning RECALL would have enhanced the teachers’ fidelity to its delivery. Conclusions: The trial processes (e.g., recruitment and consent procedures) could be easily scaled-up into a future definitive trial but the RECALL intervention requires modification to enhance its acceptability. Large class sizes, child and facilitator factors impacted on the dose (number of practice items) accessed by individual children, particularly those most at risk. This study highlights the need for thorough training for teachers and HPs engaged in the delivery of classroom interventions for children with language disorders. Trial registration: ISRCTN13633886 . Registered 7 Sept 2018 . Keywords: working memory, classroom interventions, dosage, working memory, attention, language, feasibility
Gas exchanges in sugar apple (Annona squamosa L.) subjected to salinity stress and nitrogen fertilization
Authors: Figueiredo Francisco Romário Andrade , Gonçalves Anderson Carlos de Melo , Ribeiro João Everthon da Silva , Silva Toshik Iarley da , Nóbrega Jackson Silva , Dias Thiago Jardelino , Albuquerque Manoel Bandeira de
Published: February 2020

Salinity is one of the modern agriculture major obstacles, causing several physiological disturbances in plants, adversely affecting its growth and development. Therefore, some techniques are required in order to alleviate the negative effects of salinity stress on plants, as for example an adequate nitrogen fertilization. The aim of this study was to assess the ecophysiological responses of sugar apple plants (Annona squamosa L.) submitted to different salinity levels and nitrogen fertilization doses. The experimental design was a randomized block in an incomplete factorial scheme, with five electrical conductivities of the irrigation water (ECw: 0.5, 1.01, 2.25, 3.49 and 4.0 dS m-1) and five nitrogen doses (0, 101, 350, 598.2 and 700 mg dm-3), with four replicates, generated from the Box Central Composite experimental design matrix. Through a daily course, it was observed variations in gas exchange, chlorophyll content and fluorescence parameters. The gas exchange, chlorophyll content and fluorescence parameters were measured on photosynthetically active leaves. There was significant interaction between the salinity levels (ECw) and nitrogen doses for the chlorophyll indexes. The electrical conductivity of the irrigation water caused significant negative effects on chlorophyll fluorescence. Therefore, it can be stated that the sugar apple plants ecophysiology varies through the day and that salinity affects its chlorophyll content and fluorescence.
Optimización del proceso de minado, mediante modelos matemáticos no lineales
Authors: Sosa Jose , Castillo Paredes Hebert Carlos
Published: February 2020

Las operaciones industriales como la minería a menudo requieren de constante mejoramiento de sus procesos para cumplir los estándares de calidad y por ende su productividad.Por tal el modelamiento matemático es una herramienta que ayuda a describir el comportamiento de proceso convirtiéndose en una alternativa potencial para nuestra investigación. La identificación de las variables de entrada como de salida obedecen a sistemas de ecuaciones cuadráticas lo que hace perfecto para emplear las derivadas para obtener el máximo o mínimo resultado de la función objetivo
A Multipurpose Platform for Ambient Assisted Living (ActiveAdvice): Usability Study (Preprint)
Authors: Abrantes Diogo , Teles Soraia , Tavares de Sousa Rita , Freitas Alberto , Vieira-Marques Pedro , Ferreira Ana
Published: February 2020

BACKGROUND

Aging of the global population is slowly paving the way for new markets for care products and services. The desire of older people to maintain their independence while remaining at home is boosting the development of ambient assisted living (AAL) solutions. Lack of user awareness of AAL solutions paired with an insufficient use of user-centered and participatory design approaches in the development of these products has hindered the uptake of these solutions by end users.

OBJECTIVE

This study aims to describe the usability and users’ experiences within a novel platform, ActiveAdvice, aimed at offering advice and a holistic market overview of AAL products and services.

METHODS

Usability tests were performed on the developed platform among identified prospective end users, with 32 older adults and informal carers from 4 European countries being part of the user tests. The usability and appeal of the web interface design, information flow, and information architecture were analyzed by collecting both objective and subjective measures. These would include pretest and posttest surveys, along with a series of think-aloud tasks to be performed within the platform.

RESULTS

The outcomes suggest that the ActiveAdvice platform’s objectives and functionalities are mostly aligned with the needs and expectations of end users, who demonstrated interest in using it, stressing its purpose along with its simple and intuitive interaction. Task completion rates were high, and participants had good satisfaction rates when navigating the platform. However, the tests still advocate for an improved design at some points and better disclosure of information.

CONCLUSIONS

Our findings shed light on a few peculiarities of interface design, information architecture, user needs, and preferred functionalities, which should be applied to future developments of similar platforms with related services. The AAL field could benefit from tools supporting the dissemination of available AAL solutions and how they can improve one's quality of life. These tools may benefit not only older adults but also caregivers, business owners, and governmental employees.
1 Day Artwork
Authors: Zoe Panagiota (aka Betty) Nigianni
Published: February 2020

Net art for unrealized site-specific performing arts installation, 2020

The exposition shows fragments of work prepared for an unrealized interactive site-specific public installation at Siobhan Davies Dance Studios, South London. The installation would include dance performance, video/photography and structures with objects.

The work was produced at different times between the winter and summer of 2011. The installation was to be a collaboration with dance artist Susanna Recchia and photographer Rachel Cherry. Audiences would traverse or remain on site as long as they wished.

The Critical Pathways workshop by choreographer and artist Rosemary Butcher served as the starting point. Walking journeys allowed for emerging themes, such as pilgrimage, walking-the-lifeline and potentiality. The concepts of the moving body and the plane tree, a variety imported into the city, became intertwined. The performers would enact processes related to journeying and nomadism. The installation would create a virtual landscape of remoteness: a place for reflection.

Revisiting these works, I draw from Deleuze and Guattari's notion of becoming animal to suggest that we rethink the notion of animal via the concept of the plan(e)/plateau. Deleuze and Guattari's advancement of the notion of the plan(e), from a metaphoric articulation of processes of translation into a conceptual apparatus of intersection across forms, enables the co-existence of multi-dimensional multiplicities against their reduction to two dimensions. The plane is one of consistency that is sustained across multiplicities. If it is the plane of Nature in the Deleuzian sense of natural history, it allows for the infinite multiplicity of individuals. Entering the plan(e)/plateau, one becomes part of an individuated assemblage depending on their relations of movement.

In memory of Rosemary.
Journal Reviews and Revisions: Advice from an Early Career Panel Discussion
Authors: Paul Chan  , Carrie Dossick  , Miriam Hacker  , Timo Hartmann  , Amy Javernick-Will  , Ashwin Mahalingam  , Vedran Zerjav
Published: February 2020

Editorial for Volume 9
Isolation, identification and quantification of gallic acid (gallotannins) through HPTLC in leaf galls of Madhuca longifolia (Koenig) j.f. Macb
Authors: Kumkum  , Preeti Mishra  , Rishikesh Meena  , Vidya Patni
Published: February 2020

Plant galls (cecidia) are pathologically produced cells, tissues, or organs of plants that have developed by hypertrophy and hyperplasia of plant tissues under the effect of gall causing organisms. Madhuca longifolia (Koenig) j.f Macb. is an economically and medicinally very important plant of the family Sapotaceae. It is a tropical mixed deciduous tree. Various galls due to insect infestation are found on almost all tree species. Leaf galls of Madhuca longifolia induced by insects of order Diptera and Hymenoptera represent a unique pattern of chemical perturbations which normally do not occur in normal leaf. During the present investigation, an accurate, fast and easy  HPTLC method was followed for quantification of gallic acid occur in the normal leaf and dried leaf galls of the Madhuca longifolia plant. The protocol followed in this study resulted in an intense peak and was able to give a good resolution of gallic acid from normal leaf and galled tissues of Madhuca longifolia (Koenig) j.f. Macb. Adaxial leaf gall induced by insect Mohwadiplosis Orientalis Rao belonging to Diptera class, Marginal gall induced by another Dipteran and vein gall by chalcidoiid Hymenopteran class of insect. Variation in Gallic acid present in normal leaf and leaf galls of Madhuca longifolia was critically reported. It was found that Gallic acid content increased almost two folds in gall tissues as compared to normal leaf tissue. Galled leaf (Dipteran adaxial gall) had a maximum amount of Gallic acid (344.4 ng) while in normal leaf and another leaf galls had less amount of gallic acid was found (180ng). This study is of practical importance because gallic acid is the most important active phenolic acid, which may be correlated with post-infection biochemical defense. Compound gallic acid has been reported for the first time from leaf galls of Madhuca longifolia (Koenig) j. f. Macb. Plant in the study.
CONHECIMENTOS E DIFICULDADES MANIFESTADOS POR ALUNOS DA ENGENHARIA CIVIL EM UMA AVALIAÇÃO DIAGNÓSTICA DE ESTATÍSTICA
Authors: Costa Manoel dos Santos , Moura Anna Regina Lanner de
Published: February 2020

A pesquisa que tratamos neste artigo teve por objetivo analisar os conhecimentos e as dificuldades que alunos do curso de Engenharia Civil manifestaram em relação aos conteúdos básicos de Estatística através de uma avaliação diagnóstica. A pesquisa foi realizada com 30 (trinta) estudantes que cursavam o 5º período do curso em uma universidade particular na cidade de São Luís/MA. Trata-se de uma pesquisa de natureza qualitativa de cunho interpretativo. Os resultados revelaram que os alunos apresentaram dificuldades em analisar e interpretar tabelas e gráficos, assim como em calcular as medidas de tendência central, principalmente a mediana. Apesar de a maioria ter acertado o cálculo da média aritmética e da moda, ainda assim houve uma quantidade expressiva de erros. A prova diagnóstica mostrou que as dificuldades dos alunos residem no desconhecimento conceitual, particularmente, da moda e da mediana, não sabendo quando aplicar uma e outra. Desse modo, esses resultados da prova podem servir de sustentação para um planejamento coerente às necessidades conceituais dos alunos, o que poderá contribuir para uma aprendizagem mais efetiva desses conceitos estatísticos.
Soft System Methodology (SSM) Analysis to Increase the Number of Prospective Students
Authors: Nikhlis Neilin , Iriani Ade , Hartomo Kristoko Dwi
Published: February 2020

The competition between campus, whether it’s a public college and private college in Central Java, is very tight with the increasing number of interested students for prospective students from various regions. The close competition requires many campuses to compete to provide the best facilities and services. The research objective is expected to support the "XY" university promotion strategy to help the university in the knowledge capture process. Data collection was carried out using the group discussion forum (FGD) method with a structured interview process for university leaders, university officials, marketing departments, and students. The technique used in this study is a soft system methodology (SSM). The results of this study model knowledge capture (KC) on the "XY" university promotion strategy and produce knowledge documentation that provides benefits in making policy strategies and has an impact on increasing the number of prospective new college students by optimizing digital marketing.
Peningkatan Hasil Belajar Kemampuan Membaca Pemahaman Melalui Penerapan Strategi Survey Question Reading Recite Review (SQ3R) Pada Siswa
Authors: Subaedah Subaedah
Published: February 2020

Abstrak. Tujuan penelitian ini untuk mengetahui (1) Penerapan strategi SQ3R dapat meningkatkan aktivitas membaca pemahaman siswa kelas V SDI Kananga Kec.manuju. (2) Penerapan strategi SQ3R dalam pembelajaran dapat meningkatkan hasil belajar membaca pemahaman siswa kelas V SDI Kananga Kec.manuju. Sumber data dalam penelitian ini adalah personil penelitian yang terdiri dari siswa dan guru. Jenis data yang diperoleh adalah data kualitatif yang terdiri dari tes hasil belajar dan hasil observasi. Tindakan dalam penelitian ini dilakukan dalam 3 siklus. Setiap siklus melalui empat tahap, yaitu perencanaan, pelaksanaan, observasi dan refleksi.Dalam penelitian ini, pembelajaran mengacu kepada langkah-langkah pembelajaran dengan menggunakan strategi SQ3R yaitu dimulai dari Tahap persiapan pembelajaran, Tahap Pelaksanaan pembelajaran, dan Tahap akhir pembelajaran .Dari paparan data dan pembahasan diperoleh kesimpulan pembelajaran dengan menerapkan strategi SQ3R dapat meningkatkan hasil belajar membaca pemahaman siswa kelas V SDI Kananga Kec.manuju.
PROFIL TAKSONOMI PENGETAHUAN SISWA SMP DALAMPEMECAHAN MASALAH SOAL CERITA SISTEM PERSAMAAN LINEAR DUA VARIABEL DITINJAU DARI GAYA KOGNITIF
Authors: Patta Rahmawati
Published: February 2020

The Study aimed at discovering (1) the profile of  knowledge taxonomy of student in solving story problem of linear equation system of two variables based on cognitive style, (2) the comparison of knowledge taxonomy of student in solving story problem of linear equation system of two variables based on cognitive style.The Study is a qualitative research. The instrument of the study was the researcher himself as the main instrument guided by tasks in solving story problem of linear equation system of two variables and a valid, reliable guided interview. Data were collected by conducting task based interview. The subjects of the study were two grade VIII students of SMPN 5 Marioriwawo in Soppeng district consisted of one student who categorized as field independent named as SFI (subject field independent) and one student who categorized as field dependent named as SFD (subject field dependent).
ANALISIS KESIAPAN GURU IPA DALAM IMPLEMENTASI KURIKULUM 2013 DI SMP NEGERI SE- KECAMATAN STABAT
Authors: Safitri Layil
Published: February 2020

The study of Science Teacher Readiness Analysis in 2013 Curriculum Implementation in this Public Middle School aims to find out: the readiness of Junior High School science teachers in preparing learning by implementing the 2013 curriculum and the readiness of junior high school science teachers in preparing learning tools by implementing the 2013 curriculum. The subjects in this study were 2 teachers Stabat 1 state junior high school, 4 Stabat state 2 junior high school teachers, and 5 Stabat state 5 junior high school teachers. This type of research is quantitative descriptive analysis research. The results showed that: State Junior High School Teachers in Stabat Subdistrict were declared ready in preparing the 2013 curriculum learning, this can be seen from the average percentage of 79% with the ready category; State Junior High School Teachers in Stabat Subdistrict are in the ready category in preparing the 2013 curriculum learning tools, this can be seen from the following data: Average percentage of readiness of Stabat 1 Public Middle School teachers is 79% with ready category. The average percentage of readiness of Stabat 2 state junior high school teachers is 70% in the ready category.
Penanaman Moral Untuk Meningkatkan Pribadi Berkarakter Remaja
Authors: Purwati Purwati , Yuhenita Nofi Nur , Purwandari Septiyati , Faizah Rayinda
Published: February 2020

The purpose of this study is to develop a model of moral cultivation in adolescents in the form of practical books that can be used as a guide for teachers, counselors, parents, students and practitioners based on need assessment problems by involving stakeholders in the preparation and accompaniment. This research is a Research and Development (R&D) research. This research lasted 2 years. In the first year, a study was carried out on a moral inculcation model that had been carried out and a survey of moral behavior in adolescents that became a crucial issue. Furthermore, various models of moral cultivation interventions in adolescents are combined with the values of adolescent karaker values which are priorities for completion. In this study, a qualitative descriptive method was used to collect data while the counseling model for adolescents used the literature review and evaluative methods, so that drafted models and book models of moral cultivation were arranged in adolescents. The moral cultivation model consists of 5 stages namely habituation, observation, example, consequences and coaching.
Penguatan Kemampuan Matematika Dasar Siswa Sma Melalui Kegiatan Matrikulasi
Authors: Jana Padrul
Published: February 2020

The aim of the matriculation is to improve the basic mathematics skills of high school students in order to ease the learning process in the next level. The method of this research is started with pretest, explaining material, exercise, postest and the last one in evaluation.The result of this activity is the increase of basic mathematics comprehension of the students which was 48,5% and the final result showed that student who passed the criterion of minimum mastery were 51,4%.
Sarjana (Sarana Belajar Anak Jalanan): Pemberdayaan Anak Jalanan Mandiri, Kreatif Dan Inovatif Melalui Pendidikan Kewirausahaan
Authors: Basam Fajri , Amal Amri
Published: February 2020

Makassar city is one of the cities in Indonesia that can not be separated from the problem of street children. Street children are a very vulnerable social group from various acts of violence, whether physical, emotional, sexual or social violence. Therefore, through the program of dedication to the community intend to participate actively in solving the problems of street children through the program "SARJANA (Sarana Belajar Anak Jalanan): Empowerment of Independent Street Children, Creative, and Innovative Through Entrepreneurship Education". The expected expenditure of this program is to enable street children to become independent, creative and innovative in that it no longer becomes a begging demanding society through entrepreneurship education and the provision of appropriate skills in a relatively short period of time. Methods of implementation are: (1) providing entrepreneurial materials, (2) Production and Financial Management materials, (3) Marketing Management Materials, (4) motivational materials, (5) monitoring and evaluation. The result of this devotion is that the built children already have the creative ability to produce various products that can be the future to be self-supporting.
Menumbuhkan Wirausaha Baru Bagi Mahasiswa dilingkungan UNIBA Surakarta
Authors: Dewi Riana Rachmawati , Annisa Nenden Nur , Suryo Ibnu
Published: February 2020

Tujuan dari pengabdian ini adalah untuk menumbuhkan minat berwirausaha bagi mahasiswa di UNIBA Surakarta. Metode yang dipergunakan berupa tahapan kegiatan adalah Observasi dan survey, pengumpulan materi, modelling, diskusi/konsultasi, monitoring dan terakhir evaluasi. Hasilnya, sebanyak 2 (dua) kelompok mahasiswa mulai memberanikan diri untuk membuat usaha makanan (kue) dan sesuai dengan rencana awal maka kedua kelompok mahasiswa tersebut mendapatkan bantuan / stimulan dana sebesar  Rp. 750.000,- per kelompok. Total dana yang dikeluarkan untuk praktek mahasiswa berwirausaha sebesar Rp. 1.500.000,-. Simpulan, perlu upaya yang berkelanjutan untuk dapat menumbuhkan jiwa wirausaha dikalangan mahasiswa. Upaya modelling ini dilakukan untuk memberikan semangat kepada mahasiswa yang berani untuk mencoba dan memulai (start-up) hal yang baru dan berasal dari hobi dapat dikatakan masih mampu untuk memotivasi mahasiswa memulai bisnis.
Pelatihan Penulisan Proposal Penelitian Tindakan Kelas pada Guru MTs Pesantren DDI Kaballangangg
Authors: Thalhah Sitti Zuhaerah , Raupu Sumardin , Arifanti Dwi Risky
Published: February 2020

Salah satu upaya dalam meningkatkan kualitas pembelajaran oleh seorang guru profesional adalah melakukan Penelitian Tindakan Kelas (PTK). Tujuan Pelatihan penulisan PTK yaitu: 1). Meningkatkan pemahaman para guru tentang PTK, 2). Mengembangkan pengetahuan dan keterampilan Penelitian Tindakan Kelas para guru di MTs Pesantren DDI Kaballangang. Metode yang digunakan dalam pelaksanaan pelatihan ini adalah  metode ceramah dan demonstrasi. Metode ceramah sebagai upaya untuk meningkatkan pemahaman guru berupa penjelasan tentang prinsip-prinsip PTK, prosedur pelaksanaan PTK, implementasi PTK, dan penulisan laporan PTK, untuk metode demonstrasi sebagai upaya mengembangkan pengetahuan dan keterampilan para guru berupa latihan identifikasi masalah dalam proses pembelajaran yang dapat dipecahkan melalui PTK, dan rancangan proposal PTK. Kegiatan ini sangat membantu para guru dalam mengembangkan profesinya dengan adanya hasil luaran berupa proposal PTK. Secara umum, hasil pelaksanaan pelatihan ini adalah cukup baik dan reponsif, artinya terjadi tingkat pemahaman para guru tentang PTK. Hal dapat dilihat bahwa 85% guru mampu mengembangkan keterampilan menulis proposal PTK pada saat pelatihan.
PKM Kelompok Guru Bidang Studi Biologi Kota Palopo Untuk Meningkatkan Keterampilan Media Pembelajaran
Authors: Saparuddin Saparuddin , Charmilasari Charmilasari , Syakur Akhmad
Published: February 2020

tujuan PKM ini adalah memberikan 1) Pelatihan pembuatan media pembelajaran Biologi, 2) Pendampingan pembuatan media pembelajaran biologi 3) Menyediakan sumber referensi bagi guru terkait ragam media pembelajaran biologi dan tata cara pembuatannya. Kegiatan pelatihan dan penyuluhan menghadirkan nara sumber dari dosen yang sesuai dengan disiplin ilmu yang dibutuhkan pada pelatihan pembuatan media pembelajaran. Setiap setelah mendapatkan materi kemudian dilanjutkan dengan pelatihan  pembuatan media pembelajaran. Kegiatan ini tidak sekedar pelatihan saja tetapi dilanjutkan dengan pendampingan di sekolah masing-masing.  Hasil dari kegiatan PKM menunjukkan bahwa guru-guru sangat antusias dan berpartisipasi serta memiliki keinginan yang kuat untuk tetap melanjutkan program-program yang sangat bermanfaat bagi mereka, seperti pembuatan media pembelajaran berupa awetan, multimedia, dan e- learning. Pemahaman dan keterampilan yang mereka peroleh dilaksanakn dan diterapkan di sekolah masing-masing.
“What is a scientific ideology?” Extracts from Ideology and rationality in the history of the life sciences by G. Canguilhem
Authors: Akmut Camille
Published: February 2020

a modest philosopher-historian of the sciences re-examines hisown work and the notion of “[scientific] ideology”; the latter’s history – from18th c. French philosophy through Marx to Foucault – he retraces for us here.
Dampak Sosialisasi Kebijakan Keselamatan Dan Kesehatan Kerja Terhadap Pelaksanaan Keselamatan Dan Kesehatan Kerja
Authors: Purba Hana Ike Dameria
Published: February 2020

Pada tahun 2017 terdapat30 kasus kecelakaankerja di lokasi penelitian yakni perusahaanpengolahan kelapa sawit. Tujuan penelitian iniuntuk menganalisis Penerapan Kebijakan dan Perencanaan Kebijakan Keselamatan dan Kesehatan Kerja(K3)di sebuah perusahaan pengolahan kelapa sawit. Jenis Penelitian ini adalahkualitatif dengan pendekatan fenomenologi. Data dikumpulkan melalui wawancara mendalamdan observasi langsung. Informandalam penelitian iniyaitumanajer (sekaligusAhli K3)sertasekretaris K3. Hasil penelitianmenunjukkan bahwa kebijakan K3 sudah ada tertulis, namun belum tersosialisasikan kepada seluruh elemen perusahaan. Perencanaan K3 telah dilakukandengan pengumpulan data dan penentuan prioritas. Pengorganisasian dilakukan dengan membentuk organisasi P2K3. Penerapan K3,sosialisasi dan penyediaan alat pelindung diri nasih rendahdikarenakan dana yang minim. Evaluasi dan peninjauan belum terlaksana secara sempurna. Rekomendasi bagi pihak manajemen untuk lebih memperkuat komitmenmelalui penyediaan anggaran khusus K3, penyediaan personil P2K3 yang memenuhi syarat, disosialisasikannya kebijakan K3 kepadaseluruh jajaran manajemen, karyawan dan pengunjung perusahaan.
Manajemen Kepala Madrasah dalam Meningkatkan Kompetensi Profesional Guru Pendidikan Agama Islam
Authors: Tamrin Husni , Nuzuar Nuzuar , Dedi Syahrial
Published: February 2020

The purpose of this study was to determine the management of madrasa principals in improving the professional competence of Islamic religious education teachers. In this study, the authors used a type of qualitative research with a descriptive approach that is research that describes or illustrates the state or status of phenomena. The results of the study, several things that need to be done by the madrasa head include: 1) Knowing the condition / condition of the teacher in the background of environmental, social and economic life, 2) stimulating the teacher's work spirit in various ways, 3) maintaining the availability of facilities needed to develop the ability teacher, 4) increasing teacher participation in the school environment, 5) fostering a sense of family within the school environment, 6) strengthening the relationship of the school with the community, committee and student guardians. Conclusions, the management of madrasas in improving the professional competence of Islamic religious education teachers (PAI) are: 1) involving teachers in training activities, 2) promoting discipline, 3) motivating teachers, 4) supervision. Conclusion, The application of the management of the madrasa head at the MA Al-Manshuriyah Sungai Baung has already been implemented, the professional competence of PAI teachers at the Al-Manshuriyah MA has been very good

Keywords: Principal Management, PAI Teacher Competence
Peran Kepala Sekolah Sebagai Administrator dan Supervisor
Authors: Hamidi Hamidi , Nuzuwar Nuzuwar , Nurmal Ifnaldi
Published: February 2020

The purpose of this study was to find out how the role of the principal as an administrator and supervisor. The design of this study uses a qualitative descriptive approach. The research subjects consisted of principals, teachers and staff staff at Megang Sakti Public Middle School, Musi Rawas District. The results of the study explained that the principal had applied his main tasks and functions as the principal. The conclusions of this study are that the Principal of Megang Sakti Middle School has made a good work program, this can be seen from school activities, both related to students and with educators and school education.

Keywords: Work Program, Role of Principal
Sistem Pakar IQ dalam Pengelompokan Anak Reterdasi Mental dengan Algoritma K-Means
Authors: Rahayu Novi
Published: February 2020

Reterdated mental children are children who have an intellectual level below the average. mentally retarded children are children who have intellectual deficiencies or limitations, are below the normal average, so have difficulties in academic, communication, and social tasks, and require special education services. Expert system is one part of artificial intelligence which has recently experienced very rapid development. This study aims to help the Dharma Wanita Extraordinary School to place students and students into a class with groups that are equally backward by applying the K-Means algorithm. The design of this expert system uses Data Flow Diagrams (DFD) and the programming language used to build expert systems in this study is Visual Basic. The results of the expert system built in this study help in diagnosing the level of mental reterdation based on the symptoms given by the user and the level of mental reterdation based on possible values ​​using the K-Means algorithm calculation.

Keywords:Expert System, Mental Retarded Children, K-Means Algorithm.
Desain Pembelajaran Penjumlahan dan Pengurangan Bilangan Menggunakan Konteks Bangka Belitung untuk Mendukung KBKM Siswa
Authors: Vebrian Rajab , Putra Yudi Yunika
Published: February 2020

This study aims to produce learning trajectories of addition and subtraction of material numbers using the context of Bangka Belitung, also to find out whether the use of these learning designs can support students' Critical Thinking Abilities (KBKM). The research method, this research is a validation study design research type involving 6 students in the pilot experiment stage, and 25 students in the teaching experiment stage. The alleged learning trajectory was developed from a series of learning activities using the context of the Pacific Islands, such as sahang / pepper seeds as a model in learning the addition and subtraction of numbers. The results showed the use of trajectories in the context of Bangka Belitung provided different assessment results between the students' pretest and posttest scores. Most students have been able to solve the problem of addition and subtraction and provide arguments in answering the problems encountered. In conclusion, the use of instructional design using the context of Bangka Belitung in the learning of addition and subtraction of numbers can support student CBCS.

Keywords: Numbers, Design, Learning Context
Desain Pembelajaran Menggunakan Tessellation Berbasis Pendekatan Saintifik pada Materi Translasi dan Refleksi
Authors: Widiawati Widiawati
Published: February 2020

The purpose of this study was to determine the role of tesselation in translational and reflection material in developing students' mathematical communication based on a scientific approach. The research method uses design research type validation study involving 30 students of class VII SMP 9 Palembang. The research process produces learning trajectory which contains a series of learning processes in two activities, namely scientific on translational material and scientific on reflection material. Every scientific activity consists of observing, asking, reasoning, trying, and forming networks. The results of the study showed that by providing learning material through a scientific approach, the role of tesselations could help students to carry out mathematical communication so that they could identify translational and reflection material. Therefore, students can understand the concepts of translation and reflection and solve problems related to the material. In conclusion, learning using tessellation with a scientific approach effectively helps students understand the concepts of translation and reflection. Through activities such as observing, asking, reasoning, trying, and forming networks

Keywords: Mathematical Communication, Scientific Approach, Tessellation
Morphology of the pathways of intracellular circulation in the brain
Authors: Kondor Yurii , Tykholaz Vitalii , Huminskyi Yurii
Published: February 2020

The article reflects the current position of the issue of morphologies of the pathways of intercellular circulation in the brain. There are covered main, known at present time, data on the features of the exchange between the spinal fluid and intercellular fluid, the ways of elimination of the intertissued fluid of the brain through the so-called “glymphatic system”, its components: transarterial, transvenous, and transglial ways of intercellular fluid outflow from brain tissue. It also raises the question of the role of glia namely astrocytes and ependymocytes – as the main cells forming the haemato-encephalic barrier and participating in the intercellular circulation.
Migrations Impacts on Diminishing Lingual Heritage
Authors: Chaudhry Abid Ghafoor , Zeeshan Mahwish
Published: February 2020

Socialization in the post-migration phase has a key role in shaping the behavior of the people towards a new place, culture and phenomenon. The socialization of children after the migration has potential impacts on the diminishing lingual heritage. Migration has radically exposed the younger generation to this challenge threatening the lingual heritage. They, most probably, lose their mother tongue and get socialized in other languages. This study explores the latent hazards faced by migrants from a rural setting and their impacts on the diminishing languages. The methodology of the study was descriptive. In-depth questionnaires were conducted along with a focused group discussion of sample 95 out-migrant families, living in Rawalpindi and Islamabad through a convenient sampling technique. The results from the cross-comparison of three generations show that the majority of the grandparents and parents proudly speak their native languages whereas their children are rapidly getting alienated from the language of their forefather
Aspects of Discourse Stream Analysis
Authors: Perkins Mark
Published: February 2020

The huge proliferation of textual (and other data) in digital and organisational sources has led to new techniques of text analysis. The potential thereby unleashed may be underpinned by further theoretical developments to the theory of Discourse Stream Analysis (DSA) as presented here. These include the notion of change in the discourse stream in terms of discourse stream fronts, linguistic elements evolving in real time, and notions of time itself in terms of relative speed, subject orientation and perception. Big data has also given rise to fake news, the manipulation of messages on a large scale. Fake news is conveyed in fake discourse streams and has led to a new field of description and analysis.
MR-guided focused ultrasound cerebellothalamic tractotomy for chronic therapy-resistant essential tremor: anatomical target reappraisal and clinical results
Authors: Gallay Marc N. , Moser David , Jeanmonod Daniel
Published: February 2020

OBJECTIVE

In addition to the well-recognized ventral intermediate nucleus (Vim) thalamotomy for the treatment of chronic therapy-resistant essential tremor (ET), an alternative approach targeting the posterior part of the subthalamus was proposed in the 1960s and early 1970s and then was reactualized as cerebellothalamic tractotomy (CTT) with the advent of MR-guided focused ultrasound (MRgFUS) surgery. The goal of this study was to improve target coverage and thus efficacy (i.e., tremor control and its consistency). The authors undertook a histological reappraisal of the CTT target and proposed a targeting strategy of the MRgFUS CTT based on 1) the MR visualization of the center of the red nucleus and 2) the application of preplanned target subunits realized with short sonications under thermal dose control. This study was aimed at demonstrating the efficacy and risk profile of this approach against chronic therapy-resistant ET.

METHODS

Ten consecutive patients suffering from chronic therapy-resistant ET benefited from a unilateral MRgFUS CTT and were followed over the course of 1 year. Primary endpoints were subjective tremor relief, Clinical Rating Scale for Tremor (CRST) score, activities of daily living (ADL) score, and the hand function (HF) scores HF16 and HF32. Histological reappraisal of the target led the authors to propose a standardized targeting protocol for MRgFUS CTT. Thermal doses for 18 and 240 cumulative equivalent minutes at 43°C were calculated and correlated with intraoperative and 2 days postoperative T2-weighted MR images.

RESULTS

The mean ± SD for the baseline CRST score was 48 ± 12; the score was 16 ± 7 at 3 months, and 17 ± 8 at 1 year. The mean tremor relief rated by the patients for the operated side was 95% after 2 days, 96% at 3 months, and 93% at 1 year. The mean HF16 was 11.0 ± 2.1 at baseline, 0.7 ± 0.7 at 3 months, and 0.8 ± 0.9 at 1 year (93% mean reduction). The minimum reduction for the HF16 at 1 year was 78%. There was a 51% reduction of the mean ADL score at 1 year. There was no bleeding or infection. Gait difficulties, only detectable on tandem gait, were increased in 3 patients and reduced in 2 patients at 1 year. There was no dysarthria.

CONCLUSIONS

The authors’ results suggest that MRgFUS CTT is a very effective treatment option for therapy-resistant ET.
How long is the tail end of the learning curve? Results from 1000 consecutive endoscopic endonasal skull base cases following the initial 200 cases
Authors: Younus Iyan , Gerges Mina M. , Uribe-Cardenas Rafael , Morgenstern Peter F. , Eljalby Mahmoud , Tabaee Abtin , Greenfield Jeffrey P. , Kacker Ashutosh , Anand Vijay K. , Schwartz Theodore H.
Published: February 2020

OBJECTIVE

Endoscopic endonasal approaches (EEAs) to the skull base have evolved over the last 20 years to become an essential component of a comprehensive skull base practice. Many case series show a learning curve from the earliest cases, in which the authors were inexperienced or were not using advanced closure techniques. It is generally accepted that once this learning curve is achieved, a plateau is reached with little incremental improvement. Cases performed during the early steep learning curve were eliminated to examine whether the continued improvement exists over the “tail end” of the curve.

METHODS

A prospectively acquired database of all EEA cases performed by the senior authors at Weill Cornell Medicine/NewYork-Presbyterian Hospital was reviewed. The first 200 cases were eliminated and the next 1000 consecutive cases were examined to avoid the bias created by the early learning curve.

RESULTS

Of the 1000 cases, the most common pathologies included pituitary adenoma (51%), meningoencephalocele or CSF leak repair (8.6%), meningioma (8.4%), craniopharyngioma (7.3%), basilar invagination (3.1%), Rathke’s cleft cyst (2.8%), and chordoma (2.4%). Use of lumbar drains decreased from the first half to the second half of our series (p <0.05) as did the authors’ use of fat alone (p <0.005) or gasket alone (p <0.005) for dural closure, while the use of a nasoseptal flap increased (p <0.005). Although mean tumor diameter was constant (on average), gross-total resection (GTR) increased from 60% in the first half to 73% in the second half (p <0.005). GTR increased for all pathologies but most significantly for chordoma (56% vs 100%, p <0.05), craniopharyngioma (47% vs 0.71%, p <0.05) and pituitary adenoma (67% vs 75%, p <0.05). Hormonal cure for secreting adenomas also increased from 83% in the first half to 89% in the second half (p <0.05). The rate of any complication was unchanged at 6.4% in the first half and 6.2% in the latter half of cases, and vascular injury occurred in only 0.6% of cases. Postoperative CSF leak occurred in 2% of cases and was unchanged between the first and second half of the series.

CONCLUSIONS

This study demonstrates that contrary to popular belief, the surgical learning curve does not plateau but can continue for several years depending on the complexity of the endpoints considered. These findings may have implications for clinical trial design, surgical education, and patient safety measures.