bluuebunny/crossref_metadata_2025 huggingface dataset:
Nuclear envelope impairment is facilitated by the herpes simplex virus 1 Us3 kinase
Authors: Wild Peter , Leisinger Sabine , de Oliveira Anna Paula , Doehner Jana , Schraner Elisabeth M. , Fraevel Cornel , Ackermann Mathias , Kaech Andres
Published: February 2019

Background: Capsids of herpes simplex virus 1 (HSV-1) are assembled in the nucleus, translocated either to the perinuclear space by budding at the inner nuclear membrane acquiring tegument and envelope, or released to the cytosol in a “naked” state via impaired nuclear pores that finally results in impairment of the nuclear envelope. The Us3 gene encodes a protein acting as a kinase, which is responsible for phosphorylation of numerous viral and cellular substrates. The Us3 kinase plays a crucial role in nucleus to cytoplasm capsid translocation. We thus investigate the nuclear surface in order to evaluate the significance of Us3 in maintenance of the nuclear envelope during HSV-1 infection.

Methods: To address alterations of the nuclear envelope and capsid nucleus to cytoplasm translocation related to the function of the Us3 kinase we investigated cells infected with wild type HSV-1 or the Us3 deletion mutant R7041(∆Us3) by transmission electron microscopy, focused ion-beam electron scanning microscopy, cryo-field emission scanning electron microscopy, confocal super resolution light microscopy, and polyacrylamide gel electrophoresis.

Results: Confocal super resolution microscopy and cryo-field emission scanning electron microscopy revealed decrement in pore numbers in infected cells. Number and degree of pore impairment was significantly reduced after infection with R7041(∆Us3) compared to infection with wild type HSV-1. The nuclear surface was significantly enlarged in cells infected with any of the viruses. Morphometric analysis revealed that additional nuclear membranes were produced forming multiple folds and caveolae, in which virions accumulated as documented by three-dimensional reconstruction after ion-beam scanning electron microscopy. Finally, significantly more R7041(∆Us3) capsids were retained in the nucleus than wild-type capsids whereas the number of R7041(∆Us3) capsids in the cytosol was significantly lower.

Conclusions: The data indicate that Us3 kinase is involved in facilitation of nuclear pore impairment and, concomitantly, in capsid release through impaired nuclear envelope.
Home intervention model to promote physical activity in female older adults
Authors: Ribeiro Maria da Conceição Lopes , Pinto Lélia Lessa Teixeira , Santos Andreza Soares dos , Menegucci Joilson , Virtuoso Junior Jair Sindra , Tribess Sheilla
Published: February 2019

The aim of the study was to describe the logical model of a home intervention using a motivational strategy to improve physical fitness components in female older adults. A quasi-experimental study was conducted with 91 elderly women between 61 and 80 years old, divided into intervention (IG) and control (CG) groups. The participants also answered a questionnaire with sociodemographic information, stage of behaviour change, physical activity and physical performance tests, before and after 12 weeks of intervention. The intervention was performed using a guide with home-based physical exercise associated with motivational strategies (telephone calls and home visits). e intervention with reduced interaction was planned to have a low financial cost, both in relation to the physical space and the materials necessary to practice the home-based physical activities, making feasible the applicability in different places. The logical model provides insight into the intervention and its phases of planning, implementation, and evaluation.
O currículo para além da organização das experiências e do planejamento
Authors: Souza Alexandre Augusto
Published: February 2019

O tema deste artigo é o currículo e o debate proposto trata o currículo como política e poder, para além de uma perspectiva circunscrita à organização das experiências, do conhecimento e do planejamento escolar. A pesquisa bibliográfica foi adotada como caminho de investigação. Debate realizado a partir da perspectiva pós-fundacional. Perspectiva que compreende a política como articulações abertas, não determinantes, com muitos pontos nodais, instáveis e propícias a constantes contingências. Argumenta-se o currículo como constituinte e componente de disputas, imerso em um jogo difuso, incerto e com múltiplos participantes, discursivo, performático e antagônico, onde a diferença é tornada fronteira nomeada e vigiada.
O cotidiano das aulas de Educação Física na Educação Infantil: os brinquedos em cena.
Authors: Costa João Augusto Galvão Rosa , Terra Dinah Vasconcellos
Published: February 2019

Este trabalho parte do cotidiano da educação infantil de uma escola do Município de Duque de Caxias, localizada no Bairro de Gramacho. Discute um cenário despertado por alunos das turmas 51 e 52 da Educação Infantil durante as aulas de educação física escolar. Elegemos a observação participante como instrumento de coleta de dados. Tem como base teórica Michel Certeau, Tizuko Morchida Khishimoto, Gilles Brougère, Walter Benjamin, Paulo de Salles Oliveira, Johan Huizinga que nos orientaram nas reflexões, discussões acerca das ações apresentadas pelos alunos que se apropriaram desse objeto nas aulas, gerando categorias como a imaginação, a imitação, representação e reinvenção do brincar, pois o processo de (re) construção materializou diversos conteúdos dialogados no cotidiano das aulas.
‘Sábados com Deleuze’: imagens na escrita e escrever pelo Fora entre arte, pesquisa e educação
Authors: Mossi Cristian Poletti , De Oliveira Marilda Oliveira
Published: February 2019

O artigo trata dos modos como o Coletivo de Estudos ‘Sábados com Deleuze’ tem trabalhado com textos e imagens em suas pesquisas entre arte e educação – não como reforço ou decalque de realidades fixas, mas como disparadores de tramas discursivas que excedem, ampliam, tensionam visualidades e escritas formuladoras de multiplicidades experimentativas. Também busca, a partir do conceito de Fora em Deleuze – enquanto singularidade no pensamento que se mantém distante de toda e qualquer subjetividade formada – acionar formas de fazer pesquisas menores, ou seja, marginais em relação ao que o artigo nomeia de acordo com seu campo teórico como Pesquisas Majoritárias.
HOMENS QUE TRANSFORMAM A CIDADE QUE TRANSFORMA OS HOMENS: O CASO DE CURITIBA
Authors: Mariotto Belotto Marina Marini , Martins Pura Lúcia Oliver
Published: February 2019

O presente artigo busca relacionar a dinâmica de transformação urbana de uma cidade, no caso específico o processo de pedestrização da Rua XV de Novembro de Curitiba, com a construção de imagens e significados da mesma – um espaço-tempo educativo para além da escola - a partir dos diversos atores envolvidos. Esse processo é entendido como uma rede educativa que se forma num cotidiano multifacetado – vertical, se considerarmos a relação de tempo; horizontal, se considerarmos a relação entre os atores envolvidos. Para tanto é utilizada a Teoria SCOT, que visa investigar divergências e paralelismos dentre os posicionamentos dos vários atores que contribuíram para a construção histórico-social desse artefato e assim comprovar a interdependência entre o resultado e as variáveis do processo.
O GRUPO THE MANIFEST: (RE)INVENTANDO O HIP HOP
Authors: Bonfanti Bóris Ximendes
Published: February 2019

O artigo surge de um Estudo de Caso desenvolvido na cidade de Bagé (RS), no ano de 2016, acerca da temática “Identidades juvenis e as novas configurações sociais do Hip Hop no contexto da globalização de mercado”. A análise das práticas discursivas e não discursivas de jovens integrantes do Grupo The Manifest que participaram da pesquisa indicaram descontinuidades quanto à compreensão das novas tecnologias como fator de visibilidade social e cultural e regularidades quanto à necessidade de manter certas tradições da cultura Hip Hop, evidenciando efeitos híbridos. A dança se constitui numa prática de resistência ao preconceito presente na região fronteiriça gaúcha. É nesse jogo de forças que o Hip Hop se constitui como arte da existência.
O DESEMPENHO ESCOLAR NA VOZ DOS ATORES DE ESCOLAS PÚBLICAS CATARINENSES
Authors: Dallazem Aline , Coelho Vera Rejane
Published: February 2019

Esta pesquisa investigou quais fatores podem ser determinantes e/ou condicionantes do baixo e alto desempenho escolar, tendo como base a Prova Brasil e o Censo Escolar de 2009. Para a coleta de dados utilizou-se questionários para alunos, pais, professores e observação in loco das escolas. Foram realizadas análises quali-quantitativas dos dados levantados. Na relação família e escola a investigação permeou a composição socioeconômica da família e as suas expectativas em relação aos processos pedagógicos na escola. Na relação professores e alunos evidenciaram-se as categorias: estrutura física, gestão escolar, atuação dos professores, relação família e escola, contexto sociocultural e políticas públicas.
INTERDISCIPLINARIDADE NO CONTEXTO ESCOLAR: análise do Projeto Professor Diretor de Turma
Authors: Santos Jean Mac Cole Tavares , Pereira Brena Kesia Costa
Published: February 2019

Este artigo busca analisar como o Projeto Professor Diretor de Turma aborda a interdisciplinaridade no contexto escolar a partir dos seus documentos oficiais e de entrevistas realizadas com Professores Diretores de Turma. O método utilizado é o da análise bibliográfica, documental e de entrevistas, no qual o folder de apresentação do referido projeto, o Manual de Orientações das Ações do Professor Diretor de Turma e a opinião dos professores participantes do projeto serão fontes para entender como a interdisciplinaridade é desenvolvida nesses documentos e suas relações com o(s) contexto(s) da instituição em que está inserida. O artigo está dividido em três etapas; na introdução constará uma abordagem sobre a interdisciplinaridade no contexto escolar, em seguida analisaremos a interdisciplinaridade no PPDT e, por fim, as conclusões do artigo. Como referencial teórico, utilizamos autores como Veiga-Neto (1996) para definir o que é interdisciplinaridade, os conceitos de Lopes; Macedo (2011) sobre interdisciplinaridade e hibridismo, Silva (2005) para as discussões sobre a interdisciplinaridade no currículo e Ball; Maguire; Braun (2016) para as definições sobre dimensões de contexto.
ENTRE COMEMORAÇÕES, TENSÕES E CONSTRANGIMENTOS: INGRESSO NA UNIVERSIDADE PELO SISTEMA DE COTAS
Authors: Mongim Andréa Bayerl , Oliveira Osvaldo Martins
Published: February 2019

Este artigo tem como objetivo analisar o processo de ingresso e de permanência na universidade de discentes cotistas, destacando desafios, tensões e constrangimentos. Trata-se de estudo etnográfico, com utilização de entrevistas de narrativas de vida. O ingresso na universidade constitui-se em motivo de comemoração para os discentes que, em geral, reconhecem a importância do sistema de cotas para esse fim. No entanto, além das dificuldades financeiras, convivem com episódios de estigmatização e discriminação. Parte dos estudantes busca superar tais desafios através da organização coletiva. Outros, através de sacrifício pessoal. Assim, tão fundamental quanto assegurar as condições materiais de permanência na universidade, também o é investir no combate a toda e qualquer forma de discriminação.
AUTONOMIA DISCENTE NA UNIVERSIDADE: METODOLOGIAS ATIVAS E A CIBERCULTURA
Authors: Lupion Torres Patrícia , Carneiro Virginia Bastos , Trindade Fernandes Rui
Published: February 2019

O presente artigo trata da autonomia discente em John Dewey e sua atualidade na prática das metodologias ativas no cenário educacional contemporâneo e na participação ativista em rede. O tema “Autonomia discente na universidade: metodologias ativas e a cibercultura” teve como objetivo geral refletir a perspectiva do desenvolvimento de um aluno autônomo com o aprender. Dentre os autores pesquisados estão TORRES, HILU, SIQUEIRA (2015); TRINDADE (2012).  Pôde-se inferir que nas metodologias ativas hoje aplicadas em sala de aula, encontram-se pressupostos de autonomia discente em Dewey, na medida em que a valorização do aluno como centro do aprendizado no trabalho em grupos, além do trabalho individual, é estimulada em ambiente educacional democrático.Palavras-chave: autonomia discente; ambiente educacional democrático; metodologias ativas.
A UNILA e a integração: miragem latina, horizonte neoliberal ou disputas contínuas?
Authors: Traspadini Roberta Sperandio , Valdez Leo
Published: February 2019

O objetivo principal deste artigo é apresentar a UNILA a partir de uma perspectiva histórico-crítica, marxiana, à luz da história pensada e realizada de sua missão como universidade latino-americana para a integração, à luz dos nove anos que formalizam sua existência, de 2010-2019. Utilizaremos, como recurso didático, a compreensão de três momentos chaves da história das relações diplomáticas/internacionais do Brasil com o cone sul e os demais países do continente, que se mesclam com a própria história da UNILA: 2007-2010; 2010-2016; 2016, adiante. As perguntas geradoras de condução deste artigo serão: Como nasce e se desenvolve a UNILA? Quais os contextos de política externa e nacional nos quais está inserida a UNILA?
Potencial Transformador do Ensino Superior em Cabo Verde
Authors: Rodrigues Luís
Published: February 2019

Este artigo tem como objetivo analisar o potencial transformador que o Ensino Superior poderá ter na sociedade cabo-verdiana. Embora tenha um historial ainda breve, este subsistema de ensino tem mostrado uma forte dinâmica ao longo das últimas décadas em Cabo Verde. Dadas a sua particular relação com a sociedade, urge conhecer como pode modificar algumas estruturas sociais deste país. Tomando os dados oficiais mais recentes como corpus de análise, se avaliam a acessibilidade e equidade do Ensino Superior em Cabo Verde, assim como a sua qualidade e relevância. À luz das funções das universidades propostas por Castells, se defende que as Universidades cabo-verdianas pugnem por valores humanistas, que influenciem as elites por si formadas a instaurarem padrões mais democráticos na sociedade e no mercado de trabalho. Para tal, o Ensino Superior deve mudar para um paradigma transformador do panorama da inovação, pesquisa e desenvolvimento.
A EXPERIÊNCIA DO CONSÓRCIO CEDERJ E A DEMOCRATIZAÇÃO DO ENSINO SUPERIOR NO ESTADO DO RIO DE JANEIRO
Authors: Lo Bianco Vittorio Oliveira , Faria Lia
Published: February 2019

A proposta deste trabalho é refletir, a partir dos estudos de Darcy Ribeiro em 'A Universidade Necessária' (1991) em diálogo com outros autores contemporâneos, sobre o lugar da modalidade 'Educação a Distância' na ampliação da oferta educacional de nível superior no Estado do Rio de Janeiro. Para isso, analisamos a trajetória do Centro de Educação a Distância do Estado do Rio de Janeiro (Cederj) e sua conexão com o pensamento-ação de Darcy Ribeiro – entusiasta da EaD num tempo em que a modalidade ainda não era considerada no âmbito das políticas públicas de educação. Ao traçar as linhas gerais dos caminhos e descaminhos do Cederj, indagamos sobre os desafios que se apresentam e sublinhamos sua potência enquanto via de acesso ao ensino superior por milhares de estudantes.
O Ensino Universitário no Pensamento de Gilberto Freyre
Authors: Oliveira Amurabi
Published: February 2019

Gilberto Freyre (1900-1987) destaca-se como um dos autores clássicos do Pensamento Social Brasileiro, sendo considerado um dos principais intérpretes do Brasil. Todavia, seu trabalho ainda é insuficientemente explorado no campo educacional, especialmente no debate sobre o ensino universitário. Neste breve artigo, pretendo realizar alguns apontamentos sobre como Freyre analisa a questão do ensino universitário no Brasil, apontando como suas posições neste campo relacionam-se a suas experiências acadêmicas anteriores, produzindo uma concepção de ensino associada à pesquisa e à ideia de região.
LIBERALISMO, ESTADO, COLONIALISMO E EDUCAÇAO: INTERFACES COM O PASSADO E AS LIÇÕES PARA A ATUALIDADE
Authors: Alencar Colares Anselmo , Imbiriba Sousa Colares Maria Lilia , Pires Barros Cardozo Maria José
Published: February 2019

Este artigo discorre sobre algumas questões acerca do desenvolvimento do capitalismo e suas interfaces com o Estado a partir de estudos bibliográficos das obras A riqueza das nações, de Adam Smith e Princípios de economia política e tributação, de David Ricardo. Apresenta como esses autores revelam o pensamento liberal quanto a colonização e a intervenção do Estado. Conclui-se que a obra de David Ricardo, em especial, revela que várias de suas recomendações e assertivas quanto à defesa do liberalismo estão atuais, vivas e circulando vitoriosamente, inclusive no que se convencionou chamar de neoliberalismo.  Portanto, considera-se pertinente refletir sobre estas questões, buscando compreender que as interfaces do Estado com a economia, são fundamentais para que possamos melhor compreender outros temas, entre os quais destacamos a educação.
Ethical considerations of care towards the end of life
Authors: Smithard David , Mitchell Laura , Patel Farica
Published: February 2019

As people get older and approach the end of their lives, their medical situation can become more complex and they will often need various treatments. David Smithard explains the ethical principles behind medical decisions about older persons
Evidencing good practice in the CQC's key questions
Authors: Frankova Helena
Published: February 2019

The Care Quality Commission (CQC) publishes a range of information guides for both care providers and service users. Helena Frankova discusses the CQC's guide to choosing a care home for consumers and indicates how homes can meet expectations.
Adapting contracts to Brexit and economic downturns
Authors: Warchus John
Published: February 2019

It is always important to have clear and complete contracts with suppliers, but in uncertain economic times, such as those caused by Brexit, this becomes vital. John Warchus explains how to draw up flexible contracts and minimise the scope for conflict.
Preventing and solving issues in family-run businesses
Authors: Davies John
Published: February 2019

Running a business as a family can be a great venture and can secure a job for life for family members. Unfortunately, emotional ties can widen the scope for conflict. John Davies gives advice on how to set up a business to minimise the potential for clashes.
Succesfully completing the CQC registration process
Authors: Hannah Laura
Published: February 2019

The Care Quality Commission (CQC) has recently started taking a harder line in its demands for registration. Laura Hannah describes the application process, possible risk factors for passing and the CQC's main criteria.
Examining civic education pedagogies from a sociocultural curricular perspective: Lessons from three Israeli classrooms
Authors: Cohen Aviv
Published: February 2019

Research on pedagogical aspects of civic education is a field of study that deserves further exploration and scrutiny. This study focused on the examination of pedagogical practices enacted in three Israeli civics classrooms, in which an identical curriculum was taught. Classroom observations, teacher interviews and text analysis point to how despite similarities, each case presented different teaching activities and practices, framing and influencing the citizenship conceptions promoted in each case. These findings shed light on how pedagogy interplays with content while relating to contextual factors, determining and limiting the very notions of citizenship promoted in each case.
Le patrimoine juif de la région de Draa-Tafilalet: une mémoire à ressusciter
Authors: Kich Dr. Abdeltif
Published: February 2019

Le patrimoine culturel de la région de Draa-Tafilalet se caractérise par sa grande diversité, résultat d’influences diverses qui ont contribué au modelage d’une identité riche et composée. Toutefois, ce patrimoine demeure largement méconnu, souffre des affres du temps et risque ainsi de disparaître à jamais.Parmi ce patrimoine figure l’héritage culturel et cultuel légué par les juifs, composante importante et indéniable de l’identité locale. En plus des mellahs, leurs lieux d’habitation d’antan, les différents saints et cimetières, dispersés ici et là, les objets cultuels ou usuels, tout l’apport de la tradition orale (cérémonies et manifestations diverses, rituels, carnavals, moussems etc.,), sont autant d’éléments qui témoignent d’une histoire et d’une cohabitation communes, et qui méritent d’être réhabilités et revalorisés. Ainsi, ressusciter cette composante identitaire de la région permettrait de réconcilier le pays avec son identité plurielle, de réhabiliter un patrimoine en voie de disparition et de promouvoir l’économie locale par le biais du développement du tourisme.
La valorisation touristique du patrimoine : quelles contributions au développement durable de l’espace fragile des oasis ? Le cas des Kasbahs de Skoura Ahl El Oust
Authors: Oudada Dr. Mohamed , Amara Lhoussaine
Published: February 2019

L’oasis fragile de Skoura dans la Province d’Ouarzazate connaît ces dernières années une dynamique touristique importante. Cet essor est dû principalement à ses Kasbahs, édifices splendides à base de la terre et hautement riches en valeur culturelle et architecturale. Ce patrimoine - exposant un état alarmant à tous les égards, perdant son rayonnement d’antan et ne répondant plus aux besoins modernes de la population - est non seulement négligé mais aussi non valorisé en vue d’un développement local fédérateur. Face à ce constat, nous souhaitons à travers cette communication répondre à la question suivante : Comment, et par quels acteurs, le potentiel économique de ce patrimoine pourrait-il être capable de s’imposer comme vecteur contribuant au développement durable de l’espace fragile oasien à travers la valorisation touristique innovante de ses Kasbahs ?
« Anergui » du Haut Atlas Central: un patrimoine de montagne entre perte de la biodiversité et disparition des valeurs sociétales anciennes
Authors: El Morabet Dr. Rachida , Ouadrim Dr. M. , Chettar H.
Published: February 2019

Les montagnes sont dotées d’un patrimoine original et diversifié. En revanche, sur le plan socio-économique, elles restent en retrait par rapport aux bas paysvoisins. Dans ce contexte, la valorisation du patrimoine peut être considérée comme une nouvelle chance pour le développement des espaces montagnards.La protection du patrimoine concerne aussi bien le patrimoine naturel que le patrimoine culturel. Le patrimoine géomorphologique et la biodiversité constituent des éléments fondamentaux du cadre de vie des habitants d’un lieu, donc de son environnement au sens strict du terme. L’exemple développé iciconcerne les montagnes de « Anergui » du Haut Atlas Central où la forêt et les basses terrasses au bord des fleuves constituent une richesse naturelle et unesource de survie de la population locale qui résiste à l’exode rurale. Préserver et maintenir les connaissances et pratiques des communautés locales, qui incarnent des modes de vie traditionnels, présente un intérêt pour la conservation et l’utilisation durable de la diversité naturelle. Il ne saurait y avoir de développement soutenable sans la protection de la diversité naturelle comme il ne saurait y avoir de protection de cette diversité sans la préservation du patrimoine culturel des populations autochtones.
The Intangible Heritage of Ait Atta tribes in the Southern Morocco and Zemmour tribes in the Central Plateau
Authors: Lakhal Chaymae , ElKhabous Bouchra
Published: February 2019

Most of Moroccan tribes were characterized by traveling in search of pastures to cater for the needs of cattle pasture. So, by their repetitive movements, it was caused some conflicts among themselves. It was only the results of practising the farming under the pressures of authorities. Thus, they began to know the kind of stability in the regions that they resorted to them. Despite this shift on the level of production systems, the conflict continues to fester over the resources, which were offered by the space and mainly represented in pastures and water, and the other as in the case with the tribes of Ait Atta and  Zemmour. Consequently, they were prompted to put a Charter called the Tadda or Tatta in order to avoid disputes and conflicts and peacefully take advantage from economic resources, which are provided, by the space. Besides, the Tatta played an important role in stabilizing the peace and solidarity between tribes or between a family group tribe (subfraction) with another family group tribe. And, its implications extend to this present time. Furthermore, the Al-amazigh tribes retained those values that have become to reflect its identity as well as its heritage value which have made them cohesive despite the transformations that took place since the beginning of the 20th century. Due to this important subject, we will try to treat the importance of the Tada convention of Al-amazigh tribes and its impact on agricultural activity especially the grazing, in the tribes of south-east (Ait Atta) and the tribes of the central plateau (Zemmour) so as to view more on its position as well as its various geographical spaces. In this context, some questions arise in this principal issue, which we will try to answer later:

What is meant by the Tada convention?

What are the reasons for putting this convention?

What is its impact on agricultural activity especially grazing; on the relationships as well as the social ties with the unit spatial of tribes?
Architecture traditionnelle dans les zones de montagne: contribution à l’étude de la typologie des habitations dans le Haut Atlas au Maroc
Authors: Costa Miguel Reimão , Batista Desidério
Published: February 2019

Le système montagneux du Haut Atlas marocain comprend diverses sous-unités de paysage dont l’identité provient de l’interaction entre facteurs naturels (géologie, relief, sols, climat, hydrologie, végétation) etfacteurs culturels qui caractérisent la société tribale berbère.
Exemple de géosite à forte valeur patrimoniale méconnu du grand public: Cas de la Chaîne volcanique du Moyen Atlas (Maroc)
Authors: Eddif Dr. Aâtika , Hamid M. Ahmed , Ouazzani Dr. Hassane , Boutsougame Dr. Abdelaziz
Published: February 2019

Le présent travail, se réfère à la chaîne volcanique du Moyen Atlas qui présente un intérêt géologique et pédagogique important (laboratoire volcanologique à ciel ouvert), ce qui doit être valorisé à des fins éducatives, récréatives et écotouristiques en vue d’un développement durable local et national. Notre point de vue est résolument didactique, c’est à dire que nos analyses sont centrées sur les résultats contenues dans des questionnaires distribués à la fois auprès des élèves de la 2émeannée du cycle secondaire collégial appartenant à Six collèges publics des régions de Meknès et de Salé, et des futurs enseignants des Sciences de la Vie et de la Terre (SVT) du Centre Régional des Métiers de l’Éducation et de la Formation (CRMEF) Meknès. Cet article a pour objectifs de :Présenter ce patrimoine volcanique du Moyen Atlas, dans son cadre naturel et géologique; Mettre en valeur ce géosite méconnu du grand public; Apporter un éclairage sur les résultats des enquêtes; Proposer des recommandations et perspectives qui permettraient de poursuivre d’autres finalités susceptibles de faire connaître et partager au grand public ce géosite, afin de sensibiliser à sa conservation pour des fins pédagogiques, scientifiques et écotouristiques.
Le paysage oasien entre perception et réalité
Authors: Bouzahar Dr. Soumia
Published: February 2019

Cette réflexion questionne les récits de voyage et les descriptions des auteurs sur le paysage oasien, un patrimoine actuellement en péril qu’il faudra bientotsanctuariser, afin de comprendre ce que signfie un paysage oasien aux yeux d’un visiteur et de savoir quels sont les éléments visuels et sensoriels qui définissent sa representation mentale. Cette passionnante rechreche a mis sous la lumière une “relation d’échange de service écologique” entre le visiteur et l’agrosystème oasien. Cette relation illustre approximativement la vision d’un écutouriste ou plus simplement un touriste conscient de la fragilité de ce paysge.
Les oasis historiques, un facteur dynamique pour le developement durable: Cas de l’oasis de Nefta (Sud-ouest tunisien)
Authors: Naoui Imen , Hanafi Dr. Ali
Published: February 2019

Les oasis ont historiquement contribué au développement du commerce transsaharien et des échanges Nord-Sud permettant de renforcer les liens sociaux et de maintenir les équilibres économiques des familles rurales. Le Djérid au sud-ouest de la Tunisie est l’une des régions aux multiples oasis historiques, parmi lesquelles s’individualise l’oasis de Nefta. Située aux portes nord du Sahara, Nefta est une ancienne oasis traditionnelle qui doit son existence aux sources d’eau naturelles. Elle est considérée comme un bien public et constitue un patrimoine historique et culturel riche et varié. Cependant, depuis une trentaine d’années, le maintien des équilibres naturels et socio-économiques dans cette région a été confrontée à plusieurs contraintes naturelles (manque d’eau, salinisation des eaux et des sols, ensablement…) et anthropiques (morcellement des terres, problème de main d’oeuvre qualifiée, absentéisme…). Cette situation a engendré une rupture parfois irréversible des équilibres et a embrasé le développement de cette oasis conduisant à un déclin général de certains de ses secteurs.
Immunoglobulin M and G in Virologically Confirmed Dengue Hemorrhagic Fever
Authors: Samsi Tatang K. , Wulur H. , Sugianto D. , Bartz C. R. , Tan R. , Sie A.
Published: February 2019

Starting from September 1987, a one year prospective study on lgM and lgG in dengue hemorrhagic fever, was carried out at the Department of Pediatrics, Sumber War as Hospital West Jakarta. This report describes the preliminary finding of the study from September 1987 through June 1988.

Virus isolation and serologic analysis (HI, lgG and lgM capture ELISA) for DHF were done by NAMRU 2 in Jakarta. The subjects were 151 virologically confirmed DHF patients consisting of 82 boys and 69 girls of 6 months - 15 years old.

Serum samples were collected: (I) on the day of admission; (II) on the day of discharge and (Ill) 2 weeks after the first samples. Serum samples I, II, and Ill were collected from respectively 151, 131 and 64 subjects on respectively 3.5 ± 1.7; 8.8 ± 2.7 and 16.8 ± 2.1 days of illness. Positive lgM titer from acute sera was observed in 20% of subjects. A positive correlation between HI -lgM and HI -lgG was also observed.

The percentage of positive lgM titers rose with the increase of HI titer, the percentage of positive lgG titer was lower than that of /gM but a sudden increase exceeding that of lgM was observed at the HI liter of 320 and more.

This study revealed that HI titer of640 and 1280 were indicators for the primary and secondary dengue infection respectively and lgM capture ELISA can be used as a reliable predictor for DHF even more in fatal cases where only single serum is available.
The Changing Pattern of Certain Pediatric Infectious Diseases
Authors: Kaspan M. Faried
Published: February 2019

In Indonesia results of efforts to attain a better quality of life in general, and the health development sector in particular are encouraging. Reduction of the number of cases admitted has been observed, and disease pattern seems to he changing. This article reviews the changing pattern of some infectious diseases in the Communicable Disease Ward, Department of Child Health dr Soetomo Hospital Surabaya. Further on it deals with the application of observations in respect of the Tridarma of the University e. i. Research, Education and Public/Medical seroice. Medical students, nowadays, have less practical experiences especially of the immunizable diseases. In the aspect of patient management, laboratory facilities seem to become more important, as the clinical manifestations of the diseases are less characteristic. Studies on the establisment of standard procedures for diseases that potentially become public health problems are needed.
Hospital Stay in Nosocomial Infections
Authors: Garna Herry
Published: February 2019

A 9 month prospective study on nosocomial infections was held from August 1988 till April 1989 at the Department of Child Health, Medical School, Padjadjaran University, Hasan Sadikin Hospital Bandung. The purpose of the study was to compare the duration of hospitalization in patients with and without nosocomial infections. The Department of Child Health has 4 main wards, A2 (for low sosioeconomic families), A3 (for middle and high socioeconomic families), R-17 (for neonates) anda NICU. There were 4328 hospitalized pediatrica patients observed consisting of 293 children (29 9%) in A2, 485 (11.2%) in A3, 2487 (57.5%) in R-17, and 41 episodes in NICU, showing rates of 9.9% in A2, 4.5% in A3, 8.8% in R-17 and 65.1% in NICU. The means hospital stay of patients with nosocomial infecitons were 26.77 and 22.44 days in A2 and NICU, while in A3 and R-17 17.61 and 6.75 days. The means hospital stay of patients without nosocomial infecitons were 13.11 and 9.24 days in A2 and NICU, and 1 0.48 and 3.10 days In A3 and R-1 7. Length of stay specific nosocomial infeciton rate rose with the duration of hospitalization, with 3 2% of patients staying upt to 6 days, 16.7% of patients staying 7-13 days, 19.7% of patients staying 14 to 20 days, and 48,8% of patients staying 35 days or more. It can be concluded that the longer the length of stay, the higher the number of nosocomial infections. The overall mean hospital stay of patients with nosocomial infection was 2.4 times higher than that without nosocomial infection.
Conjunctival Mycobacteriosis
Authors: Rahajoe Nastiti N. , Setyanto Darmawan B. , Rhum Muhammad , Usman Tetty A.
Published: February 2019

A 6 1/2- year old Indonesian girl with 30 kg of body weight was consulted to the Department of Child Health, Cipto Mangunkusumo Hospital - Medical School University of Indonesia , Jakarta, for eye, surgery tolerance. At 3 1/2 years old, she came for the first time with a granulomatous tumor on her left eye. Excision was done, and histopathologic examination revealed granulation tissue corresponding to tuberculosis. The patient was referred to the Department of Child Health for further exploration. Sensitin test was positive for Mycobacterium intracellulare, not for Mycobacterium tuberculosis. The tumor reappeared twice and the last histopathologic examination revealed nonspecific granulation tissue.
Embroidered vestments: findings in the Terceira Island (Azores)
Authors: Ribeiro Maria Manuel Velasquez
Published: February 2019

A set of vestments with embroidered orphreys applied on velvet fabric, belonging to the Church of the College of Angra do Heroismo (Terceira Island, Azores), have been attributed, by 19th-century studies, to an English origin and unknown date, but prior to the 16th century. Another set found in a rural church of the island (Ribeirinha), comprises a chasuble and a stole, with embroidered orphreys as well. The origins of this set and its incorporation into the assets of the parish remain uncertain. This article attempts to deepen the knowledge about the presence of these liturgical textiles in the Azores along with their date and place of production and it aims to reconstruct the process of their recognition and consolidation as cultural heritage objects.
Aplikasi biomaterial aktif dari daging ikan gabus (Channa striata) untuk penyembuhan luka pascaoperasi pada hewan model tikus Wistar
Authors: Sunarno Sunarno , Damayanti Rahayu , Devi Alfisa , Fikri Muhammad , Pratiwi F , Ayu Linda
Published: February 2019

One problem for postoperative patients is tissue recovery takes a long time due to the occurrence of blood clotting disorders and immune system. Snakehead fish was known to contain bioactive ingredients that can potentially speed up the process of tissue repair as a result of injuries. Snakehead fish meat contains a lot of minerals, albumin, and amino acids needed for tissue protein synthesis and increases the antioxidant glutathione. This study was conducted to test the extraction of snakehead fish flesh against skin tissue wound healing in Wistar rats. The study was conducted with a completely randomized design consisting of three treatments with 6 replication, which include (P0) a negative control (without treatment madecassol and snakehead fish meat extract), (P1) madecassol commercial drug treatment, and (P2) treatment of snakehead fish meat extract. Each material was injected intramuscularly in Wistar rats at a dose of  9 ml/kg bb for 7 days. Data analysis uses Anova followed by test Honestly Significant Difference (HSD) with a significance of 95%. Treatment of snakehead meat extract with a dose of 9 ml/kg bb a significant effect on skin tissue repair after injury, better than treatment with madecassol and control with the average value of extensive tissue remaining after recovering from the condition of the wound by 0.2 cm2; 0.33 cm2; and 0.4 cm2, respectively. Snakehead fish meat extract with a dose of 9 ml/kg bb injected intramuscularly can accelerate the recovery of tissue in the skin after the wound in Wistar rats.
Kandungan klorofil dan karotenoid Kacang Tunggak (Vigna unguiculata (L.) Walp.) pada umur tanaman yang berbeda
Authors: Hendriyani Ika Susanti , Nurchayati Yulita , Setiari Nintya
Published: February 2019

Chlorophyll is a pigment of photosynthesis which is also efficacious as a cure for brain, lung, and oral cancer, and can be used as a disinfectant, antibiotic and dietary supplement, while carotenoids are useful as antioxidants. The content of the two pigments is strongly influenced by the age of the plant, especially for vegetable crops used in leaves such as cowpea (Vigna unguiculata (L.) Walp.). The purpose of this research is to know the pattern of chlorophyll content and carotenoid of cowpea leaf during the growth phase and to know the age of the right plant for harvesting cowpea so that the highest chlorophyll and carotenoid content is obtained. Cowpea seeds obtained from seeds are added then planted in pots containing ready-made planting media in the greenhouse. Chlorophyll and carotenoid analyzes were performed at different plant ages from 1 to 11 weeks. The research design used is Completely Randomized Design. Data were analyzed using variance analysis and continued with Duncan test at 95% significance level. The results showed that the highest chlorophyll and carotenoid content was produced by the cowpea leaf in the vegetative phase or before the flowering time. The highest chlorophyll content was obtained at 4WAP (weeks after planting) of age crop, while the highest carotenoid content was obtained in 3WAP.
Effect of rosella-based kombucha tea on the lipid profile on hyperlipidemic rats (Rattus norvegicus)
Authors: Darmawan Ahmad Edi , Sunarno Sunarno , Dhani Vinsensius M , Fairuzzaki Garin F
Published: February 2019

The purpose of this study was to determine the lipid profile of white rats (Rattus norvegicus) with high-fat feed after fermentation of rosella kombucha with various concentrations. This study used 20 white male rats (Rattus norvegicus) aged two months, with rosella kombucha treatment fermented for five days at 25oC per oral. This study used Completely Randomized Design with four treatments (for 21 days) and four replications, namely: P0 = Control, rats were only given food and drink as usual (with the same type of rat feed). P1 = 1 ml of pork oil/day for 14 days + 1.8 ml of rosella kombucha 50% in the morning and evening for seven days. P2 = 1 ml of pork oil/day for 14 days + 1.8 ml of 75% rosella kombucha morning and afternoon for seven days. P3 = 1 ml of pork oil/day for 14 days + 1.8 ml of 100% kombucha rosella morning and afternoon for seven days. The variables measured were levels of LDL (Low-Density Lipoprotein) and HDL (High-Density Lipoprotein). The data obtained were analyzed using ANOVA followed by Duncan Test with 95% confidence level using SPSS 16.0 software. The results showed that administration of rosella kombucha did not have a significant effect on LDL and HDL levels of white rats (Rattus norvegicus). Based on the results of the study, it can be concluded that the 5-day fermentation of kombucha rosella with various concentrations did not affect LDL and HDL levels.
Polymorphous Low Grade Adenocarcinoma of the Parotid Gland. Cytological, Histological and Immunohistochemical Features and Review of the Literature
Authors: Tamiolakis Demetrio , Thomaidis Vasilios , Tsamis Ioannis , Kariki Eleni , Kotini Athanasia , Lambropoulou Maria , Boglou Panagiotis , Papadopoulos Nikolaos
Published: February 2019

Aim: Polymorphous low grade adenocarcinoma of the salivary glands (PLGA) is a low grade neoplasm that predominantly occurs in the minor salivary glands. In this site is amenable to biopsy and histologic diagnosis. However, experience with cytological findings in these tumors is limited. We describe the cytology of this entity. Experimental design: Touch imprint cytology of a primary parotid PLGA is specified and correlated with histology. Results: Smears were hypercellular showing branching papillae, sheets and clusters of uniform cells with bland nuclei, dispersed chromatin and no nucleoli. The cells had a scant to moderate amount of eosinophilic cytoplasm. They formed tubular structures containing hyaline globules. Conclusions. The cytologic differential diagnosis of PLGA includes adenoid cystic carcinoma, pleomorphic adenoma, and monomorphic adenoma. PLGA should be considered in the differential diagnosis of head and neck tumors, where the cytology suggests on of the above mentioned tumors, even when the clinical findings (involvement of a major salivary gland, lymph node metastasis) is not typical of PLGA.
Predicting Factors Contributing to Length of Stay in Hospitalized Chronic Obstructive Pulmonary Disease (COPD) Patients: The Role of the Emergency Room
Authors: Díaz-Peromingo José Antonio , Grandes-Ibáńez Jesús , Fandińo-Orgeira José Manuel , Barcala-Villamarín Pablo , Garrido-Sanjuán Juan Antonio
Published: February 2019

Background: Exacerbation of chronic obstructive pulmonary disease (COPD) is a common cause of hospital admission and COPD patients usually have a long stay in hospital. Methods: The objective of this study was to identify factors predicting length of stay in patients with exacerbation of COPD when seen in the emergency room. We analyzed clinical and biological variables. Results: Patients with diminished breath sounds, systolic pressure higher than 140 mmHg, diastolic pressure higher than 90 mmHg and recent previous hospitalization for exacerbation of COPD had the longest hospital stay. Conclusions: Recognition of this clinical profile in the emergency room may help to increase efforts in order to diminish length of stay in these patients.
The “Edge Effect” After Implantation of β-Emitting (55Co) Stents with High Initial Activity
Authors: Červinka Pavel , Šťásek Josef , Costa Marco Aurelio , Štursa Jan , Fišer Miloslav , Vodňanský Petr , Kočišová Michaela , Veselka Josef , Pleskot Miloslav , Malý Jaroslav
Published: February 2019

The aim of this study was to evaluate the incidence and the cause of “edge restenosis” after implantation of high activity 41.1 μCi±1.2 μCi=1520 kBq±44 kBq, β-emitting (55Co) stents. Proton bombarding in cyclotron has brought the radioactivity. Intravascular ultrasound (IVUS) investigation has been completed in 10 patients. The angiographies performed at 6 month revealed restenosis >50 % in 5 cases (50 %). The analysis of edges (5 mm distally and proximally to the last stent struts) showed no significant changes in TVV (187.3±62.60 mm3 and 176.9±53.5 mm3) but PMV increase significantly (i.e. neointimal proliferation) from 61.9±31.2 mm3 to 82.2±43.4 mm3 (p<0.04) and was the major contributor (from 66 %) to lumen volume loss (125.4±40.7 mm3 and 94.7±22.2 mm3, p<0.02). In conclusion, neither statistically significant positive nor negative remodelling at the “stent edges“, were present. Statistically significant increase in plaque+media volume (i.e. neointimal hyperplasia) and reduction in lumen volume were found. The cause of “edge restenosis” was especially (from 66 %) due to increase in plaque+media volume (i.e. neointimal hyperplasia). Probably, main reason for “edge effect”/neointimal hyperplasia was in this trial sharp fall-off in radiation at the edges of the stents.
Cytologic Differential Diagnostic Problems in Ulcerative Cervicitis
Authors: Tamiolakis Demetrio , Kotini Athanasia , Koutlaki Nikoleta , Galazios Georgios , Liberis Vasilios , Anastasiadis Panagiotis
Published: February 2019

Objective: To improve the detection rates in the determination of signs consistent with ulcerative cervicitis against signs of intraepithelial neoplasia, in PAP smears. Study design: We investigated the frequency of establishing a diagnosis of a simple ulcerative cervicitis by histology in a cohort of 58 females with cervical cytology suggestive of intraepithelial neoplasia. Results: There was found a detection rate of 81.58% in the determination of ulcerative cervicitis by cytology and a rate of 100% in the determination of HPV-infection, CIN1, CIN2 and CIN3 respectively. There was no statistically significant difference between cytology and histology in the diagnosis of ultracerative cervicitis (p>0.5, chi-square). Conclusions: There is an overestimation of the cytological signs in the diagnosis of ulcerative cervicitis 18.42 %). There is also an excellent agreement in the diagnosis of HPV-infection and CIN grades (100 %) between cytology and histology, discordant with the literature (2.4 %–71 %).
What Are Appropriate Initial and Salvage Therapies for Patients with Thrombotic Thrombocyopenic Purpura (TTP)?
Authors: McCarthy Leo , Orazi Atillio , Miraglia Charles , Waxman Daniel , Skipworth Elaine , Danielson Constance
Published: February 2019

Although much has been learned about the pathophysiologic process of thrombotic thrombocytopenic purpura (TTP), both diagnostically and therapeutically, since its initial description by Moschowitz in 1924, its etiology and treatments remain, in many instances, problematic. Thrombotic thrombocytopenic purpura remains a rare entity whose etiology is usually unknown, but several drugs and infections have now been implicated in its development. Although treatment by plasma exchange has gained worldwide acceptance, the optimal exchange media is not known, nor the volume and duration of exchange therapy, not appropriate salvage therapies. Without the benefit of randomized controlled trials, its treatment, to a large extent, remains not evidence-based but “eminence-based“, making the same mistakes with increasing confidence over decades.
Arbuscular mycorrhiza and dark septate endophyte fungal associations of Oryza sativa L. under field condition: colonization features and their occurrence
Authors: Chakraborty Kripamoy , Banik Subam , Debnath Atithi , Das Aparajita Roy , Saha Ajay Krishna , Das Panna
Published: February 2019

The present study was aimed to study monthly colonization of arbuscular mycorrhizal (AM) and dark septate endophyte (DSE) fungal associations in rice. The presence of mycorrhizal structures in the roots confirms the colonization by AM fungi. The pattern of hyphae and arbuscules denotes Arum type of AM fungal morphology. The presence of dark coloured septate hyphae running frequently on the epidermal layer and in root cortex and the occurrence of microsclerotia marks the colonization by DSE fungi. The co-occurrence of both AM and DSE fungi ensure dual colonization by two distinct fungal groups. There was significant increase in arbuscules, vesicles and hyphal percentages from first to third month in both the samples collected from two sites. In the third month, AM colonization significantly higher in both the sites. DSE colonization percentages do not differ significantly in first to third month. A total of nine AM fungal species were recovered from two sites. This study is an effort to make aware the local farmers about the usefulness of these native AM mycobiota which can be a preferable choice over chemical fertilizers leading to ecofriendly organic farming.