bluuebunny/crossref_metadata_2025 huggingface dataset:
Electrical and viscoelastic parameters of erythrocytes in patients with different degrees of arterial hypertension
Authors: Gromov A A , Kruchinina M V , Rabko A V , Baum V A , Generalov V M
Published: February 2021

We investigated the electrical and viscoelastic parameters of red blood cells in patients with hypertension of 1 and 2 degree. We marked the increase of variations in the characteristics of red blood cells with an increase in the degree of hypertension. We identified the correlations of erythrocytes parameters with biochemical indicators reflecting hyperlipidemia, microalbuminuria and the presence of inflammation. It was noted that the velocity of red blood cells to the electrodes, the dipole moment can be the markers of initial stages of endothelial dysfunction. It was suggested that the decrease of deformability, surface charge of red blood cells are the important pathogenetic factors in the progression of hypertension, therefore, requires additional emphasis in the treatment of this disease.
Torasemide: additional benefits for postmenopausal women with arterial hypertension
Authors: Tkacheva O N , Runikhina N K , Sharashkina N V
Published: February 2021

Effective and safe diuretic torasemide has additional effects of renin-angiotensin-aldosterone system blockage. Torasemide can be used as monotherapy or combined with other antihypertensives. In low doses torasemide produces pronounced antihypertensive effect without augmentation of excretion of potassium and water with urine. Long-term administration of torasemide was not associated with significant effects on lipid, purine, carbohydrate, or electrolyte metabolism parameters. Torasemide particularly effective in postmenopausal women, as these women are more likely formed low-renin hypertension. Therefore, torasemide can be used more widely in modern clinical practice.
Effect of angiotensin II receptor antagonists on left ventricular hypertrophy, vascular elasticity, and lipid and carbohydrate metabolic parameters in metabolic syndrome
Authors: Nedogoda S V , Salasyuk A S , Chalyabi T A , Barykina I N , Pocheptsov D A , Ledyaeva A A , Tsoma V V , Chumachek E V
Published: February 2021

Aim: to evaluate the antihypertensive efficacy and effects of telmisartan and losartan on metabolic parameters in patients with arterial hypertension and metabolic syndrome. Subjects and methods. A blind randomized, controlled, parallel group comparative (telmisartan versus losartan for 24 weeks) trial enrolled 60 patients with arterial hypertension and metabolic syndrome. Results. Significant differences were found in favor of telmisartan in antihypertensive activity, cardio-, angio-, and nephroprotection and ability to improve lipid and carbohydrate metabolic parameters. Only did telmisartan reduce the manifestations of insulin resistance and hyperleptinemia in patients with hypertension and obesity. Therapy with telmisartan versus losartan exerted a pronounced positive effect on anthropometric parameters and fat deposition rate. The drugs were found to be well tolerated and to cause no adverse reactions in both groups.
Coagulogic risk factors of heart disease in the adult population of Tomsk
Authors: Dobrovolsky A B , Titaeva E V , Yarovaya E B , Storozhilova A N , Zhernakova Yu V , Oschepkova E V , Panchenko E P , Trubacheva I A , Serebryakova V N , Kaveshnikova V S , Chazova I E , Karpov R S
Published: February 2021

The following paper presents an analysis of fibrinogen and D-dimer levels and global index characterizing the anticoagulant function of protein C (TromboPas). 1104 people (25–64 years of age) of Tomsk adult unorganized population were examined within the framework of ECCE-RF-2012 (Epidemiology of cardiovascular diseases and their risk factors in the Russian Federation) project. The relationships of these parameters with the main demographic and clinical characteristics were analyzed. The presence of at least one of the markers of hypercoagulability, which include fibrinogen level higher than 3,7 g/l D-dimer – 500 ng / ml, and the index of inhibition of thrombin formation in the TromboPas (PICI%) test, that islower or equal to 84%, was found in 55,44% of the patients. At the same time, in 2,72% of the surveyed population a combination of all three hypercoagulation markers was observed, whereas a combination of at least one of the mentioned markers and / or risk factors such as arterial hypertension (AH) and obesity (BMI≥30 kg/m2) was observed in 36,87% of patients. Hypercoagulation markers, hypertension and obesity were absent only in 19,47% of patients. Thus, the results suggest a high risk of thrombotic complications of cardiovascular disease (CVD) in the studied population and justify the feasibility of developing adequate methods to prevent them.
Riociguatas the first innovative guanylatecyclase stimulators class drugs for pulmonary arterial hypertension patients treatment
Authors: Chazova I E , Martynyuk T V
Published: February 2021

Pulmonary arterial hypertension (PAH) drug therapy including prostanoids, endothelin receptor antagonists, type 5 phosphodiesterase inhibitors, can improve the possibilities for treatment and control of this progressive and irreversible disease. The modern research vector aims at exploring the potential therapeutic targets, as at developing new drugs that can affect the previously set target. NO synthase production disturbance plays an important role in PAH pathogenesis; this is determined by the powerful vasodylative action, as well as by anti-inflammatory, anti-proliferative, and antiaggregatory effects. Riociguat is the first in a new class of soluble guanylatecyclase stimulators to have proved effective in phase II of clinical trials. In a randomized, double-blind, placebo-controlled phase III of PATENT-1 (Pulmonary Arterial Hypertension soluble Guanilatcyclase-Stimulator Trial) study, 443 patients with PAH symptoms were randomized to receive placebo of riociguat in a single dose of 2,5 mg (with a dose titration based on tolerability to 2,5 mg three times a day) or a dose of 1,5 mg (with a dose titration according to portability to 1,5 mg three times a day). The study included patients not previously treated with PAH-specific therapy or those who have already taken endothelin receptor antagonists or prostanoids (except for parenteral ones). The primary endpoint of the PATENT-1 study was the distance dynamics in the 6-minute walk test (D6MH) to 12th treatment week. Secondary endpoints were: the dynamics of pulmonary vascular resistance (PVR), the level of NT-proBNP, functional class (FC) (WHO), the change in the time to developing of clinical deterioration, dyspnea (Borg index), indicators of quality of life and safety. By the 12th riociguat treatment week D6MH hasincreased by an average of 30 m in the group treated with the maximum single dose of 2,5 mg, or has decreased by an average of 6m in the placebo group (difference between groups, 36 m, 95% confidence interval 20–52 m, p
Experience of treating hypertension in an outpatient setting: a clinical case
Authors: Agafonov A N , Khozyainova N Yu , Petruschenkova O V
Published: February 2021

Presents a case of treating hypertension stage II, 2 nd degree, risk 3 (high) in a patient of 54 years on an outpatient basis. For antihypertensive therapy was chosen fixed combination of quinapril 20 mg + hydrochlorothiazide 12.5 mg (Akkuzid) 1 times a day. Assigned therapy has several solutions to achieve the urgent tasks: to reach target blood pressure (BP) during the entire two weeks, to maintain the target blood pressure level throughout the observation period (24 weeks) to achieve regression of left ventricular hypertrophy. Effectiveness of prescribed therapy served as the main reason for high patient complains of treatment.
Dynamics of arterial hypertension and its impact on mortality in the Russian population
Authors: Balanova Yu A , Shalnova S A , Deyev A D , Konstantinov V V , Kapustina A V
Published: February 2021

Aim. To assess impact of hypertension status in Muscovites cohort aged 35-64 examined twice for 20-years period on all cause mortality. Material and methods. Population based cohorts consists of 2029 Muscovites (1046 men and 983 women) observed twice during 21,8 years period. The same protocol was used with response rate - 65%. Participants defined as hypertensives if their SBP was ≥140 mm Hg, and/or their DBP was ≥90 mm Hg, and/or they reported current use of antihypertensive medications. Effective treatment - the proportion of those with SBP
Local rigidity of the walls of the carotid artery at the site of formation of atherosclerotic plaques in patients with arterial hypertension
Authors: Vakhovskaya T V , Tripoten M I , Pogorelova O A , Balakhonova T V , Loukianov M M , Boytsov S A
Published: February 2021

Aim: To study the local elastic properties of the arterial wall at the site of atherosclerotic plaque and adjacent areas «healthy» wall of the common carotid artery in patients with arterial hypertension (AH).Materials and methods. The study included 25 patients (3 men, 22 women) with AH 1-2 grad in combination with moderate carotid atherosclerosis and lipid metabolism disorders. All patients underwent conventional ultrasound duplex scanning of the carotid arteries to determine the severity of atherosclerotic carotid arteries and the structure of atherosclerotic plaque. Determination of parameters of the local rigidity - the elasticity of the arterial wall and the atherosclerotic plaque, was carried out on the ultrasound system ALOKA a7. Was scanned and the surroundingarea atherosclerotic plaque sections of the arterial wall in the B/M mode using echo-tracking method.Results. A significant increase in the hardness of the arterial wall in atherosclerotic plaque as in the adventitia and its surface, as compared with the adjacent «healthy» wall of the carotid artery. Atherosclerotic plaque base has significantly greater rigidity and less flexibility than its surface. Conclusion. The formation of atheroma by the action of arterial pulse pressure develops heterogeneity elastic properties carotid wall not only along the artery, but in the atherosclerotic plaque (between its base and the surface). This indicates of different mobility plots artery and plaque and can lead to the formation of the mechanical instability of atherosclerotic plaque in patients with hypertension.
Pleiotropic features of dihydropyridine calcium channel antagonists
Authors: Anikin G S
Published: February 2021

It is hard to imagine modern medicine without safe drugs (D). Often, adverse drug reactions (ADR) are the reason for drug with drawal, which is quite effective as a whole. The main dihydropyridine calcium channel antagonists (DCCA) ADR are the edema of shin and tachycardia, causing this drug with drawal. Lercanidipine is aquite new member of this class; it is a highly lipophilic compound, which blocking the influx of calcium ions through L-type calcium channels, by maintaining the high intramembrane concentration. This review provides the data on the efficacy and safety of lercanidipine and its pleiotropic features.
The treatment options of the new angiotensin II receptor blocker - azilsartan medoxomil in the therapy of hypertension in patients with metabolic disorders
Authors: Zhernakov Yu V , Chazova I Ye
Published: February 2021

One of the key pathogenic mechanisms of the arterial hypertension (AH) development in patients with metabolic syndrome is the activation of the renin-angiotensin-aldosterone system (RAAS). According to these advantages we need to use drugs inhibiting the RAAS in the treatment of AH patients. This article demonstrates the information about the new Angiotensin II receptor blocker (azilsartan) application in AH patients with metabolic disorders. There are several studies showing the high antihypertensive efficiency of azilsartan as compared with other antihypertensive drug classes in patients with obesity and metabolic disorders. According to the pilot studies, azilsartan has additional positive metabolic effects: increases tissue sensitivity to insulin and reduces body fat mass.
Effectiveness and safety of indapamide sustained-release in the treatment of post partial hypertension
Authors: Gaisin I R , Iskchakova A S , Shilina L V , Maksimov N I , Vavilkina Zh V , Sava N P
Published: February 2021

Background. Hypertensive disorders in pregnancy have been recognized as an important risk factor for atherosclerotic CVD in women. Therefore, lifestyle modifications, regular blood pressure control, and control of metabolic factors are recommended after delivery, to avoid complications in subsequent pregnancies and to reduce maternal cardiovascular risk in the future. There are no uniform recommendations for the treatment of post partial hypertension (HT) yet.Methods. In a case-control, open-label 1-year study, 54 post-partum hypertensive women (aged 22-38 years; body mass index 26.7±3.8 kg/m2; 18 with previous pre-eclampsia, 18 pre-existing HT, 18 pre-existing HT plus superimposed pre-eclampsia) were studied. Nursing mothers (n=27) received adjusted-dose methyldopa (Egis) 500-2000 mg daily, 27 non-feeding women received indapamide SR (Servier) 1.5 mg daily. No significant differences observed between two groups at baseline.Results. After comprehensive follow-up, clinical blood pressure was not found to differ substantially between indapamide and methyldopa groups (124.8±3.2/83.2±2.1 mmHg vs 125.3±3.8/81.5±2.9 mmHg respectively; p =NS), but indapamide significantly better improved diurnal BP patterns. No maternal adverse effects were registered in both groups, except for sleepiness and bad mood in 18.5% of methyldopa patients. There was a significant difference in weight reduction, in favour of indapamide (-11.3 kg vs -2.7 kg; p =0.032), as well as in decrease of microalbuminuria (-189.2 mg/24 h vs -51.4 mg/24 h; p
The first results of an international clinical trial VICTORY:the efficacy and safety of antihypertensive valsartan monotherapy and the fixed combination of valsartan and hydrochlorothiazide usingdifferent dosage regimens in patients with 1-2 degree arterial hypertension
Authors: Chazova E Evgen'evna , Martyniuk T V
Published: February 2021

On behalf of the group of russian researchers. The aim of the VICTORY study was to estimate the efficacy and safety of valsartan monotherapy using different dose regimes (Valsacor® 80, 160, 320 mg) and its fixed combination with hydrochlorothiazide (HCTZ) using different dosage regimens [Valsacor® H160 (valsartan 160 mg + HCTZ12.5 mg), Valsacor® H320 (valsartan 320 mg + HCTZ 12.5 mg) Valsacor® HD320 (valsartan 320 mg + HCTZ 25 mg)] in reaching the target level of blood pressure (BP) in patients with 1-2 degree arterial hypertension (AH).Materials and methods. There are 130 patients with 1-2 degree AH were enrolled in the open international multicenter prospective randomized study from 7 cities in 8 Russian Clinical Centers in Russia. The starting dose of valsartan depended upon the previous antihypertensive treatment: for previously untreated patients - 80 mg (Valsacor® 80 mg, KRKA, Slovenia) with randomization into 4 parallel groups (n=108) for the patients receiving antihypertensive therapy during the screening, after washout 7-day period of Valsacor® 160 mg application with randomization into 8 parallel groups (n=22). Besides the dynamics of clinical BP, we evaluated the impact of therapy on pulse ware velocity, erectile function (in men) and the quality of life. Results. The clinical BP in 130 patients with AH with age of 55.6±11.5 years (65% women) at the moment of inclusion into the study was 157.6/95.1 mm Hg. The BP was reduced to 140.9/85.3 mm Hg on the 4-week of valsartan 80 or 160 mg application. Valsartan titration or the combination of valsartan and HCTZ on the 8-week helped to reduce BP to 135.2/83.5 mm Hg. The 16-week treatment showed the BP reduced to 129.2/79.4 mm Hg. ( p
The rise of cardiac biomarkers due to planned PCI and 1-year prognosis in patients with stable coronary artery disease and arterial hypertension
Authors: Mironova O Yu
Published: February 2021

Aim. The aim of our study was to assess the prevalence of myocardial infarction (MI) type 4a and myocardial damage due to planned percutaneous interventions (PCI) in patients with stable coronary artery disease (CAD) and arterial hypertension (AH).Material and methods. 281 patients were screened before the enrollment in our study. 183 patients with stable CAD were included in our study whose levels of cardiac troponin I and CK-MB (creatine kinase-MB fraction) were studied after PCI. We divided patients into the groups according to their levels of cardiac troponin I after PCI and CK-MB (group 1 - no elevation; 2 - elevation 1-3 upper limits of normal - ULN; III - more than 3 ULN).167 patients had AH. In case of detected rise of CK-MB and/or troponin echocardiography and cardiac magnetic resonance imaging (MRI) were performed. Results. The prevalence of MI type 4a was 10,8% and periprocedural myocardial damage - 16,2% respectively. After performing the discriminant analysis we sought to build a prognostic model and calculate the formula of periprocedural myocardial damage probability: 0,871 × gender (male = 0; female = 1)+0,516 × angina pectoris functional class + 0,022 × age (years) - 0,011 × (estimated glomerular filtration rate (eGFR) using the Modification of Diet in Renal Disease - MDRD formula) + 0,27 × number of diseased coronary arteries ≥2,731.Conclusion. Women with low EGFR (MDRD), mutivessel disease and angina pectoris class 3-4 (NYHA) have the highest risk of MI type 4a. The most difficult localization for PCI is circumflex artery.
Safety of beta-agonists with different duration of action in patients with arterial hypertension and broncho-obstructive diseases
Authors: Dolgusheva Yu A , Agapova O Yu , Zykov K A , Chazova I E
Published: February 2021

Objective. To examine the safety of beta-agonists (BA) with different duration of action in patients with arterial hypertension (AH) and chronic obstructive pulmonary disease (COPD) or bronchial asthma (BA).Materials and methods: 40 patients (22 - male, 18 - female) with AH and COPD and AH and asthma aged 18 years were enrolled and examined initially. At the next three month, patients were treated with 3 types of BA: at the 1st month - with salbutamol (SABA), at the 2nd - with formoterol (LABA), at the 3rd - with indacaterol (ULABA). Initially, after one week and at the end of each month blood pressure (BP) and heart rate (HR) on the visit, oxygen saturation of peripheral blood, computer spirometry, serum potassium in blood, electrocardiogram, were evaluate. Initially, after one week and at the end of three month of treatment with SABA, LABA and ULABA all patients underwent holter monitoring and ambulatory blood pressure 24-monitoring.Results. Baseline, 1-month, 2-month, 3-month BP and HR levels on the visit were similar among all patients ( p =NS). At the end of the 3rd month of treatment with BA different duration of action in patients with AH and COPD daily average systolic BP (SBP) was lowered than initially ( p
Predictors of progression of atrial fibrillation in patients with arterial hypertension
Authors: Podzolkov V I , Tarzimanova A I
Published: February 2021

Recently progress has been made in the study of the natural history of atrial fibrillation (AF) from the stage without clinical manifestations, to the final stage, represent an irreversible arrhythmia associated with the development of serious cardiovascular complications. The progression of the arrhythmia worsens the clinical status of patients and prognosis. Slowing down progression of AF should be considered as a priority treatment of this cardiac arrhythmia.Aim. The study the predictors of AF progression in patients with arterial hypertension.Materials and methods. The study included 136 patients with essential hypertension and paroxysms of AF. Prospective observation of the patients was carried out from 2011 to 2015. The progression of the arrhythmia was considered: increased frequency of paroxysms of AF; the emergence of long-term persistent attacks or permanent form of arrhythmia.The results of our work allow to conclude that the predictors of progression of AF in patients with hypertension and preserved systolic left ventricular function are: endothelial dysfunction, increased vascular wall stiffness, left ventricle hypertrophy and increased size of the left atrium.
The validation of the questionnaire for the early detection of pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension
Authors: Valieva Z S , Glukhova S I , Martyniuk T V , Chazova I E
Published: February 2021

The objective: to identify pathognomonic symptoms and signs of different groups of pulmonary hypertension (PH), analyze the possibility of early diagnosis of patients with PH and the validity of the questionnaire.Material and methods. The questionnaire consists of 6 sections: clinical symptoms, physical examination, anamnestic information; diseases associated with PH; signs of pulmonary arterial hypertension (PAH) according to electrocardiography, chest radiography, echocardiography. All sections of the questionnaire were filled by physician. Was held an analysis of clinical symptoms, medical history, physical examination, methods of instrumental examination of 81 patients with idiopathic PH in comparison with 29 patients with PAH due to congenital heart defects - PAH-CHD, 36 patients chronic thromboembolic PH - CTEPH and the control group - 48 patients with essential hypertension. In addition, the validity of the questionnaire was evaluated: structural, the criterion and discriminant validity.Results. The leading complaint in IPAH patients was syncope; in patients with PAH-CHD the most often detected signs were cyanosis and accentuated pulmonary component of 2d heart sound; in patients with CTEPH - cough, they had a history of venous thrombosis of the lower limbs and the debut of the disease has been associated with pregnancy.Conclusion. Development and validation of a screening questionnaire allows to improve approaches to early detection of various forms of PH, allows identify specific symptoms that more typical of definite forms of PH.
The possibility of a new receptor blocker to angiotensin in improving control of hypertension. Non-intervention international multicenter observational prospective study of the use azilsartan medoxomil in patients with arterial hypertension and overweight or obesity in the Russian Federation and the Republic of Kazakhstan
Authors: Zhernakova Yu V , Chazova I E
Published: February 2021

Currently, there is evidence of a rather low efficacy of antihypertensive therapy, especially in patients with obesity and metabolic disorders that indicate the need for the search of new highly effective antihypertensive agents that have additional features to prevent destruction of target organs and cardiovascular complications. On the Russian pharmaceutical market antihypertensive drugs presents receptor blocker to angiotensin - azilsartan medoxomil (Edarbi®). The article is published design of study of the effectiveness of azilsartan medoxomil in patients with arterial hypertension and overweight or obesity in daily clinical practice of the Russian Federation and the Republic of Kazakhstan.
Loop diuretics in the treatment of hypertension and edema syndrome
Authors: Kirichenko A A
Published: February 2021

The comparison of the pharmacological properties, clinical efficacy of furosemide and torasemide in patients with hypertension and edema. Torasemid similar to furosemide mechanism of diuretic action but has a higher bioavailability (>80%) and a longer half-life (3-4 h). In-non-diuretic doses (2.5-5 mg/day) torasemide used in the treatment of essential hypertension, both as monotherapy and in combination with other antihypertensive drugs. When used in these doses torasemide reduces diastolic blood pressure to below 90 mm Hg in 70-80% of patients. In patients with chronic heart failure torasemide in a dose of from 5 to 20 mg/day is an effective diuretic. The bioavailability of torasemide when administered in patients with CHF decreases only slightly, the diuretic action is smoother, it is less likely to cause the phenomenon of "rebound". Total and cardiovascular mortality in patients treated with torasemide, was lower (2.2% compared with 4.5% in the comparison group; p
The role of bisoprolol in the management of patients with arterial hypertension
Authors: Nedogoda S V
Published: February 2021

According to the different recommendations (NICE, JNC-8, ASH/ISH) concerning the treatment of AH, β-blockers are in 3rd-4th place among the other antihypertensive drugs (AHD), because the results of various meta-analyses show that their antihypertensive activity was less potent in comparison with other classes of drugs, their worst impact on hard endpoints (especially in people over 60). The application of beta-blockers can increase the risk of diabetes mellitus (especially in combination of thiazide-type diuretics) and shows negative effects on aortic elasticity. However, "new" β-blockers occupy leading positions because of number of main AHD characteristics (cardioselectivity, amphiphilicity, duration of action, metabolic neutrality, etc.). Bisoprolol can be regarded as the drug of choice in patients with AH associated with ischemic heart disease (stable angina), especially with the trend towards high heart rate, and in patients with chronic heart failure. Bisoprolol is effective both in elderly patients (people over 60) and in younger one (younger than 60).
Demographic and clinical differences between idiopathic and scleroderma-related pulmonary arterial hypertension: Russian National Registry analysis
Authors: Yudkina N N , Valeeva E G , Taran I N , Nikolaeva E V , Paramonov V M , Kurmukov I A , Valieva Z S , Arkhipova O A , Martynyuk T V , Volkov A V , Nasonov E L , Chazova I E
Published: February 2021

Pulmonary arterial hypertension associated with systemic sclerosis (SSc-PAH) and idiopathic pulmonary arterial hypertension (IPAH) belong to group I in the clinical classification of PH, but there is evidence for significant differences in their survival due to current therapy. Objective: the objective of this report is to compare pts with (SSc-PAH) and (IPAH) based on data of Russian National Registry. Patients and methods: in the study we included 52 pts with IPAH and 50 with SSc-PAH. There were no differences in functional class (FC). Diagnosis was based on RHC. Results. At the moment of diagnosis average age of patients with SSc-PAH was 15 year higher (p
A fixed combination of amlodipine and losartan: effectiveness and safety in abnormal weather conditions in patients with arterial hypertension
Authors: Ageev F T , Smirnova M D , Fofanova T V , Blankova Z N , Vitsenya M V , Tsybulskaya T V , Neverova E F , Samsonova N S
Published: February 2021

Actuality. The effect of drugs on adaptation to abnormal temperatures is one of the most important questions put to practical medicine by the heat waves of recent years. One of the controversial issues - safety of use during the heat wave of calcium channel blockers (ACC) and blockers of receptors for angiotensin II (ARBS). The goal is to evaluate the efficacy and security of treatment of patients with arterial hypertension (AH) during the heat wave of a fixed combination of ARBS+ACC (Lortenza, KRKA). Materials and methods. Included 26 patients with hypertension 1 and 2 degrees from 42 to 81 years. All patients underwent measurement of office blood pressure, electrocardiography, body sphygmography with the determination of the pulse wave velocity and selectively CAVI, biochemical analysis of blood, estimation of osmolarity of blood, questionnaire: visual analogue scale, a questionnaire for patients exposed to heat, the test of adherence to treatment Moriscos-Green. Estimated diaries of self-control of blood pressure. The inclusion visit took place in spring 2016, 1st visit was in May - June 2016, 2nd - during heat waves, 3rd - September - October 2016. Results. The observed decrease in systolic blood pressure and diastolic blood pressure (p=0.000) to the target values, preserved for the whole period of observation. According to the diaries of self-control of blood pressure controlled blood pressure 81% of patients. During a heat wave, this value decreased to 58%, in autumn - to 63%. The 3rd visit achieved a reduction in heart rate at -6.0 (-11.1; and 2.8) beats/min; p=0.007. A noticeable decrease of the pulse wave velocity from 15.2±3.4 to 14.4 V±3.0 m/s; p=0.01 and CAVI in of-2.1 (to -2.9; -0.65); p=0.01; the decline in uric acid level c of 415.3 to 346.2 mmol/l (p=0.04) and creatinine on the 2nd visit compared to baseline (p=0.02). Electrolyte shifts and increasing the osmolarity of the blood during heat waves have not been identified. There is a growing commitment therapy (p=0.04) and quality of life to 20.0 (7.4; 23.3); p=0.000 by visual analogue scale. Conclusion. Fixed combination of losartan and amlodipine (Lorenza) is an effective, safe and may be recommended for patients receiving AG in the hottest period.
Calcium antagonists in pharmacotherapy in patients with concomitant cardiac pathology: priorities of the recommendations in clinical practice
Authors: Kompaniets O G , Linchak R M , Ketova G G
Published: February 2021

The article discusses the problem of using calcium antagonists in clinical practice. Physicians' judgments in prescribing calcium antagonists showed its compliance with current guidelines for the treatment of hypertension. Emphasizes the feasibility of dihydropyridine calcium antagonists as efficacy and safety tools in patients with combination of arterial hypertension, stable angina and chronic heart failure. The article discusses the results of clinical efficacy studies of felodipine in a combined cardiac pathology with cognitive impairment.
The patients of high cardiovascular risk of healthy: unrecognized metabolic syndrome
Authors: Blinova N V , Zhernakova Yu V , Chazova I E , Oshchepkova E V
Published: February 2021

Aims: to study the target organ damage in patients with metabolic syndrome (MS) and arterial hypertension (AH) 1 degree. Design and methods. We included 20 healthy volunteers and 60 patients with MS, AH 1 degree and dyslipidemia. Office blood pressure, 24-hour ambulatory blood pressure monitoring, measurements of the endothelial vasoactive mediators, carotid ultrasonography and echocardiography had performed at baseline. Results. The majority of patients with MS and AH 1 degree had metabolic abnormalities; the levels of vasoactive mediators were higher in comparison with control group; 30% of patients had signs of atherosclerotic process in carotid arteries; 40% of patients had left ventricular hypertrophy. Conclusion: the results showed high prevalence of target organ damage in patients with MS and AH 1 degree.
Mitral insufficiency: systematization, conservative and surgical treatment
Authors: Cherepanova E V , Gurevich M A
Published: February 2021

The article concerns mechanisms, clinical features, diagnostics, possible complications and treatment of mitral insufficiency. Much attention is given to modern diagnostic methods, principles for case management and indications for surgical treatment.
Quality assessment of examination of patients with arterial hypertension in primary health care (according to the Russian arterial hypertension register data)
Authors: Oshchepkova E V , Lazareva N V , Chazova I E
Published: February 2021

Objective: to assess the quality of examination of patients with arterial hypertension in primary health care. Materials and methods. The study was carried out with the Arterial Hypertension Register method (a software with remote access, medical data inputs were made from medical records of patients with AH). The study included a selection of 29 126 patients with AH under care in primary health care in 22 regions of Russia in 2010-2014. 35% were males, females were older by 3.7 years (60.9±12.5 years and 64.6±12.0 years respectively, p
Dihydropyridine calcium antagonists: conscious choice
Authors: Ostroumova O D , Vikentev V V , Abrosimov A G , Smoliarchuk E A
Published: February 2021

This article contains information concerning the aspects of pharmacokinetics and pharmacodynamics of dihydropyridine calcium antagonists. The authors have discussed the evidence-based amlodipine treatment of arterial hypertension, ischemic heart disease and chronic heart failure. The authors present the comparison of the efficacy, safety and application characteristics of the different dihydropyridine calcium antagonists that can be used in specific clinical cases.
Quality of life in patients with idiopathic pulmonary hypertension: the first experience of trimetazidine
Authors: Kuznetsova E G , Glukhova S I , Martynyuk T V , Nakonechnikov S N , Chazova I E
Published: February 2021

Objective - to estimate the quality of life with therapy of trimetazidine in patients with idiopathic pulmonary hypertension, I-III functional class. Material and methods. In this study we included 29 patients (27 women and 2 men) aged 41.9±10 years. All patients had a common complain of angina-like symptoms. The patients were divided into 2 groups. The first group consisted of 11 patients (1 men and 10 women) who were additionally prescribed trimetazidine 35 mg twice daily for 24 weeks. The second group included 18 patients (1 men and 17 women) who continued to receive standard and specific therapy. At baseline and after 24 weeks all patients were examination, which included: laboratory (general and biochemical blood tests, D-dimer), clinical and instrumental examinations (electrocardiography, echocardiography, chest radiography, scintigraphy, a 6-min walking test, spirometry). We are take into consideration: age, sex, functional class (World Health Organization), complaints, tolerance, a 6-min walking test, Holter electrocardiogram in 12 lead, SF-36 questionnaire. Results. We analyzed the questionnaire SF-36 quality of life compared to before and after treatment trimetazidine: improvement in general health (p
Features of the use of torasemide in arterial hypertension
Authors: Baryshnikova G A , Chorbinskajya S A
Published: February 2021

The article deals with the choice of diuretic in arterial hypertension and presents data on the antihypertensive efficacy of the loop diuretic torasemide. Data on the mechanisms of antihypertensive action of torasemide are presented, including a unique antialdosterone effect. The article reports on the absence of a negative effect of the drug on carbohydrate, lipid, purine metabolism and electrolyte balance, positive effect on the target organs, very good tolerability. It is advisable to use torasemide more widely in a "non-diuretic" dose (2.5-5 mg / day) for the treatment of arterial hypertension as in monotherapy as in combination with other antihypertensive drugs.
Modern concepts of the relationship between obesity and erectile dysfunction in patients with arterial hypertension
Authors: Alekseeva T A , Litvin A Y
Published: February 2021

In this article, we will consider the main modern concepts of obesity, as well as the definition, severity, prevalence and its pathogenetic features. The review will present various methods for diagnosing obesity, including laboratory diagnostics and visualization methods. The role of biomarkers of adipose tissue in the diagnosis of obesity will be considered. The advantages and disadvantages of various visualization methods for diagnosing obesity will be described in detail. Also in the article epidemiology, etiology and pathogenesis of erectile dysfunction will be described, diagnostic possibilities depending on the etiological factors of this pathology will be considered. Details of the relationship between erectile dysfunction and obesity in patients with arterial hypertension will be given. In this review a cascade of hormonal and metabolic disorders, leading to the formation of a vicious circle in patients with obesity erectile and dysfunction will be considered. The data of the results of both international and domestic research are given. In conclusion, erectile dysfunction is presented as an independent predictor of cardiovascular disasters.
Markers of early target-organ brain damage in essential arterial hypertension: the search continues. Possibilities of diffusion tensor magnetic resonance imaging
Authors: Anikin G S , Storozhuk I K , Filyazova Ya Yu
Published: February 2021

Rosuvastatin is one of the most frequently prescribed drugs for primary and secondary prevention of myocardial infarction and stroke. The present article deals with the main studies confirming the effectiveness of rosuvastatin in patients with different cardiovascular risks.
Obstructive sleep apnea syndrome
Authors: Litvin Aleksandr Yur'evich , Chazova Irina Evgen'evna , Litvin A Y , Chazova I E
Published: February 2021

The paper describes the major mechanisms of occurrence of obstructive sleep apnea syndrome (OSAS). Large populationbased
randomized studies in this area show the importance and prevalence of obstructive sleep respiratory disorders and provide
evidence for their clinical significance in the practice of a therapist and cardiologist. Multiple references demonstrate the
specific features of an association of OSAS with cardiovascular diseases, as well as major treatment approaches and methods
at the present stage are given.
Key words: obstructive sleep apnea syndrome, pathogenesis, epidemiology, diagnosis, clinical picture, treatment, cardiovascular
diseases
The improved form perindopril in treatment of arterial hypertension in various clinical situations (PREMIA)
Authors: Mychka Viktoriya Borisovna , Zhernakova Yu V , Chazova Irina Evgen'evna
Published: February 2021

The treatment of ACE inhibitors reduce risk of cardiovascular morbidity and mortality. The patients with grade 1-2 hypertension (n=2060) and at least one additional risk factors, subclinical organ damage, established CV or renal disease, diabetes mellitus or metabolic syndrome are recruited in this clinical study. The article presented of study design.
The condition of parameters of memory, attention and thinking at men of young age officers under the contractwith arterial hypertension.
Authors: Davidovich Il'ya Mikhaylovich , Afonaskov Oleg Vladimirovich , Staroverova Yuliya Konstantinovna
Published: February 2021

Aim: to evaluate memory, attention and thinking functions indices in young hired military officers depending on their 24-hours blood pressure profiles.
Materials and methods. The study was made in 49 patients with stage 1-2 arterial hypertension, aged 39,3±0,8, who did not take hypotensive medicines or took them occasionally. 24-hours blood pressure monitoring was performed with assessment of cognitive functions (memory, attention) depending on the stage, degree and duration of the disease. The control group included 12 men with no signs of arterial hypertension.
Results. Comparing with the controls the memory, attention and thinking indices in hypertonic patients were found to be lower .even in those who had the first degree of hypertension and duration of the disease less than 5 years. The hypertonic patients showed lowering of attention and semantic memory scopes irrespective of duration of the disease. There was a negative correlation between monitored blood pressure data and memory, attention and thinking indices.
Conclusions. Light cognitive dysfunctions can be found in young hired military officers with initial arterial hypertension but they are more typical for stage 2 of the disease
Vascular wall status and its link with perivascular adipose tissue and other fat depots in young patients with abdominal obesity
Authors: Zheleznova Ekaterina A , Zhernakova Juliya V , Pogorelova Olga A , Tripoten Mariia I , Blinova Nataliia V , Shariya Merab A , Azimova Marina O , Gorieva Shurat B , Maslov Andrei V , Balakhonova Tatiana V , Chazova Irina E
Published: February 2021

Aim. To evaluate the common carotid artery (CCA) intima-media complex thickness (IMT) and the presence of atherosclerotic plaques (ASP) in young people with abdominal obesity who don’t have metabolic syndrome and those who have it, as well as a link between fat depots (perivascular, visceral, subcutaneous, epicardial) and CCA IMT. Materials and methods. The study included 145 people aged 18-45 years. They were divided into 3 groups: group 1 (n=18) - healthy volunteers (control group), group 2 (n=48) - patients with abdominal obesity and no more than one additional risk factor (metabolically healthy) and group 3 (n=79) - patients with metabolic syndrome. In persons included in the study the following parameters were measured: the height, weight, body mass index, waist circumference, fasting blood glucose, glucose tolerance, uric acid, lipid profile, insulin and the insulin resistance index (HOMA-IR). They also were given a 24-hour blood pressure monitoring, and an evaluation of CCA IMT, a presence of ASP in the carotid arteries and a maximum degree of internal carotid stenosis was performed using the duplex scan of brachiocephalic arteries. Computed tomography (Aquilion One Vision Edition, Toshiba, Japan) with determining subcutaneous, visceral, perivascular, epicardial fat was performed, and the ratio of subcutaneous to visceral fat was calculated. Results. Significant differences in mean CCA IMT were revealed only between persons of group 1 and group 3 (p=0.025), while the median of IMT were within normal ranges (group 1: 0.49 [0.46; 0.56]; group 2: 0.53 [0.49; 0.59]; group 3: 0.56 [0.52; 0.62]). Significant differences in a distribution of individuals with increased IMT between groups were also not revealed. However, the proportion of individuals with ASP was significantly higher in group 2 compared with group 1 (p
EARLY FOREIGN EDUCATION THROUGH THE USAGE OF INTEGRATED LESSONS
Authors: Кошелева Екатерина Максимовна
Published: February 2021

Рассматривается актуальность применения интегрированного урока иностранного языка в раннем возрасте. Предложены приемы и техники по обучению с учетом возрастных психолингвистических особенностей детей. Описываются основные формы и принципы работы педагога английского языка в условиях детского сада, рассматриваются трудности в освоении иноязычного обучения в раннем возрасте. Приводится пример работы с дошкольниками на занятиях английским, которые могут быть реализованы как педагогом, так и родителями. Автор приходит к выводу, что изучение языков положительно влияет на развитие языковых, познавательных и коммуникативных способностей ребенка, расширяет кругозор, служит средством повышения и удержания интереса к иностранному языку.

The article discusses the relevance of using an integrated foreign language lesson at an early age. Learning techniques and teaching methods are proposed taking into account the age-related psycholinguistic characteristics of children. The author describes the necessary forms and principles of the work of an English teacher in a kindergarten, considers the difficulties in mastering foreign language from an early age, and gives the example of working with preschoolers in English classes. Both the teacher and parents can implement it. The author concludes that the study of languages has a positive effect on the development of linguistic, cognitive, and communicative abilities of the child, broadens his horizons, and serves as a means of increasing and maintaining interest in a foreign language.
THE SUBSTANTIATION OF THE NECESSITY OF NEW LANGUAGE WRITING SKILLS SYSTEM DEVELOPMENT AT A TECHNICAL UNIVERSITY
Authors: Сапожникова Оксана Сергеевна
Published: February 2021

Рассматривается проблема эффективности формирования умений письменной речи в процессе обучения английскому языку в вузах технического профиля подготовки. Проведен ретроспективный анализ требований к результатам обучения письменной речи в примерных программах по дисциплине «Иностранный язык» для неязыковых вузов. Проанализированы современные учебники для неязыковых вузов на их соответствие требованиям ФГОС ВО 3++ к формированию умений иноязычного письма. Обоснована необходимость повышения эффективности обучения письму на основе реализации системного подхода, сопряженного с конкретной постановкой цели - обучение письменной речи, ее проекции на содержание и поиск новых путей реализации.

The problem of developing writing skills efficiency in the process of teaching English at technical universities is reviewed. A retrospective analysis was made of the requirements for the results of teaching writing in exemplary programs on the subject «Foreign language» for non-linguistic universities. The resources of modern textbooks for non-linguistic universities regarding the implementation of the requirements of the latest Federal State Educational Standards 3++ to the development of foreign language writing skills are considered. It is stated that improvement of the efficiency of teaching writing is possible only through the implementation of a systematic approach, coupled with a specific statement of the objectives of teaching writing, their projection on the contents and search of new ways of their realization.
ESEARCH OF PERSONAL ADAPTIVE ABILITIES AND EMOTIONAL INTELLIGENCE OF ORDINATORS OF MEDICAL UNIVERSITY
Authors: Слесаренко Людмила Александровна
Published: February 2021

Представлены результаты исследования личностных адаптационных способностей и эмоционального интеллекта ординаторов. В качестве инструментария использовались многоуровневый личностный опросник (МЛО-АМ) «Адаптивность» А.Г. Маклакова и С.В. Чермянина и методика определения эмоционального интеллекта Н. Холла. Результаты представлены на основании описательных статистик.

The results of the study of personal adaptive abilities and emotional intelligence of residents are presented. The multi-level personal questionnaire (MLO-AM) «Adaptability» by A. G. Maklakov and S. V. Chermyanin and the method of determining the emotional intelligence of N. Hall were used as tools. The results are presented based on descriptive statistics.
EXPERIENCE OF INTRODUCTION OF MIXED LEARNING TECHNOLOGY IN THE STUDY OF THE RUSSIAN LANGUAGE CHINESE STUDENTS
Authors: Тинтин Ли
Published: February 2021

В статье описывается опыт внедрения технологии смешанного обучения на кафедре русского языка Даляньского университета информатики Neusoft. Рассматриваются проблемы обучения русскому языку в Китае и пути решения этих проблем, на примере Даляньского университета информатики Neusoft. В статье приведены этапы и результаты внедрения технологии смешанного обучения на кафедре русского языка.

This article describes the experience of implementing mixed learning technology at the Department of Russian language of Dalian University of Informatics Neusoft. The article deals with the problems of teaching Russian in China and ways to solve these problems, on the example of Dalian University of Informatics Neusoft. The article presents the stages and results of the introduction of mixed learning technology at the Department of Russian language.
Osteogénesis imperfecta en adulto: un desafí­o en el manejo anestésico
Authors: Monar Edwin , Lira Fabiola
Published: February 2021

La incidencia de Osteogénesis Imperfecta (OI) es aproximadamente de 1 por cada 10 000a 20 000 habitantes. Es una enfermedad que en la mayorí­a de los casos es autosómica dominante y quese presenta cuando existen mutaciones en los genes que codifican al colágeno tipo I. La supervivenciade estos pacientes depende del grado de afección de la OI, existiendo casos que llegan a la adultez. Estebreve reporte presenta el manejo anestésico de una paciente con OI que fue solicitada para corrección deprolapso uterino con difí­cil acceso de la ví­a aérea y dificultad en el manejo ventilatorio por la deformidadde la caja torácica, realizándose intubación con video estilete y manejo de la ventilación con Volumen Tidalpara protección de pulmón con caracterí­sticas restrictivas. El manejo anestésico se realizó con AnestesiaTotal Intravenosa (TIVA), utilizando infusión con propofol y remifentanilo y dosis única de rocuronio paraintubación con la finalidad de evitar utilizar medicamentos que puedan desencadenar hipertermia maligna.