bluuebunny/crossref_metadata_2025 huggingface dataset:
Identification of the Distribution of Seawater Intrusion Using the Resistivity 2D Method in the Belawan Area, North Sumatra Province
Authors: Muzambiq Said , Husin Amir , Herlina Netti , Gultom Tri Maylani
Published: January 2025

Excessive withdrawal of deep groundwater has an impact on changing the direction of groundwater flow so that the hydrostatic pressure decreases, resulting in seawater intrusion. This study aims to determine the areas indicated by seawater intrusion and determine the direction of distribution of saltwater contaminants. The method used is the Schlumberger configuration resistivity geoelectric method to obtain resistivity values with a path length of 200 meters. In the research results obtained in the field, processing using Ms. Excel and interpreted using IP2WIN.. The results of the processing using IP2WIN are then processed using Surfer to draw the correlation between Track I and Track III in 2D form. Line I which indicated seawater intrusion, namely the seventh layer with a resistivity value of 0.198 m, was designated as seawater intrusion. Track II shows seawater intrusion, namely in the sixth layer seawater intrusion is found with a resistivity value of 0.0584 m. Track III shows the presence of seawater intrusion, namely in the eighth layer seawater is found with a resistivity value of 0.0035 m. Based on the research conducted, the distribution of seawater intrusion from Track I on Jalan Raya Belawan, Belawan Harbor, Bagan Deli Village, Medan Belawan District, which is close to the beach. Seawater intrusion flows to the southwest which is the location of Track II and Track III through the groundwater layer affected by the intrusion.
Bio-efficacy of cow-urine-based neem, nochi and adhatoda extracts against sucking pests and impact on natural enemies in organic rice
Authors: Ganesan K , Anilkumar B , Suganthy M , Venugopal S , Manivannan V , Soundararajan R P , Murugan M , Sangeetha S V
Published: January 2025

To overcome the adverse effects of synthetic pesticides in rice, organic farming by utilizing botanicals is a viable alternative. The bio-efficacy of cow-urine-based extracts of neem (Azadirachta indica), nochi (Vitex nigundo) and adhatoda (Adhatoda vasica) was studied. The experiments targeted major sucking insect pests, brown plant hopper (BPH) and green leaf hopper (GLH), in wetland paddy fields, Tamil Nadu Agricultural University, Coimbatore, during Rabi 2023. The results showed that the cow-urine-based extracts of neem, nochi and adhathoda (NNA) leaves @15 % were most effective against BPH and GLH with 70.23 and 72.48 percent reduction over control (PROC), which was on par with NNA leaf extract @10 % and the PROC were 67.13 and 68.18, respectively. Individual 10 % leaf extracts of Neem, Nochi and Adhatoda recorded lower PROC values against BPH (53.68 %, 55.40 % and 53.68 %) and GLH (52.68 %, 55.75 % and 53.02 %) compared to the combined NNA extract at 15 % and 10 %. The neem, nochi and adhatoda (NNA) leaf extract @ 15 % has a moderate impact on beneficial arthropods, expressed as percent impact over control (PIOC) for natural enemies like spiders (27.70), coccinellids (32.99), rove beetles (10.88), mirid bugs (19.95) and ground beetles (43.99). Foliar application of NNA leaf extract at 10 % resulted in lower PIOC values (26.28 %, 31.33 %, 10.14 %, 18.74 % and 39.86 %, respectively, for spiders, coccinellids, rove beetles, mirid bugs and ground beetles), indicating its relative safety for beneficial arthropods. The eco-friendly, cost-effective and residue-free nature of the cow-urine-based neem, nochi and adhatoda leaf extract can be easily incorporated into the Integrated Pest Management programmes in the organic rice production system.
Bartók and the Topic of Drunkenness. Theory in Performance
Authors: Hellaby Julian
Published: January 2025

This article considers Mikhail Bakhtin’s notion of carnivalisation (1984 [1968]), which he divides into four categories, the second of which is eccentric or inappropriate behaviour where conventionally unacceptable behaviour becomes normalised in a carnival setting. Bakhtin believed that real-life carnivalisation, as practised in ancient and medieval societies, had gradually become eclipsed by its transfer to literature, and this essay further transfers it to music. Burlesque may be regarded as a particular manifestation of the Bakhtinian carnival and the focus of this article, the second of Bartók’s Three Burlesques Op. 8/c (“A Little Tipsy”), features what is here regarded as the topic of drunkenness. The carnivalisation of drunken behaviour is very much apparent in this music because outside the context of the carnival, drunkenness is generally the object of official censure whereas within the carnival context, as processed through Bartók’s music, it is rendered harmless, humorous and socially acceptable to the attentive listener. The notion of drunkenness as a topic is defended and this is followed by an examination of how best to portray it in performance – how to project the topic but without so much musical distortion that the piece’s coherence collapses. There are three principal sources for the performer to consult: the piano score (1911), the orchestral score of the composer’s later transcription (1931) and Bartók’s own recorded performance (1929). The author negotiates between these three sources, assessing a variety of performances both orchestral and pianistic, offering a personal interpretative strategy in the process.
Prolonged sitting is not associated with altered shear‐mediated dilation of the internal carotid artery, despite impairing lower limb endothelial function
Authors: Saito Shotaro , Dora Kento , Karaki Marino , Kunimatsu Narumi , Tsukamoto Hayato , Sugawara Jun , Iwamoto Erika , Ogoh Shigehiko
Published: January 2025

The present study aims to examine the effect of 4 h of continuous sitting on cerebral endothelial function, which is a crucial component of cerebral blood flow regulation. We hypothesized that 4 h of sitting may impair cerebral endothelial function similarly to how it affects lower limb vasculature. Thirteen young, healthy participants were instructed to remain seated for 4 h without moving their lower limbs. The blood flow and shear rate (SR) in the popliteal and internal carotid artery (ICA) were measured using duplex Doppler ultrasound. During the 4‐h sitting, peripheral (popliteal artery) and cerebral (ICA) endothelial function were assessed every hour. We induced peripheral and cerebral flow‐mediated dilation (pFMD and ICA FMD) using hyperemia (5 min of cuff inflation on lower limb, then deflation) or hypercapnia (30s of hypercapnia, end‐tidal partial pressure of CO2 + 9 mmHg), respectively. We then calculated each relative peak dilation from the baseline diameter to identify both pFMD and ICA FMD. We observed a significant decrease in pFMD starting at 2 h from the onset of sitting, and this reduction persisted throughout the 4‐h sitting [Base (6.8 ± 4.2%) vs. 2‐h (3.9 ± 2.0%), p = 0.044; vs. 3‐h (3.2 ± 1.8%), p = 0.016; vs. 4‐h (3.2 ± 1.9%), p = 0.005]. In contrast, during the 4‐h sitting, ICA blood flow, SR, and ICA FMD remained unchanged (p = 0.062, p = 0.068, and p = 0.203, respectively). Unlike peripheral endothelial function, cerebral endothelial function remained stable during 4‐h sitting. This suggests that the acute effect of prolonged sitting on cerebral vasculature differs from that of lower limb vasculature.
Quantification of training‐induced alterations in body composition via automated machine learning analysis of MRI images in the thigh region: A pilot study in young females
Authors: Ramedani Saied , Kelesoglu Ebru , Stutzig Norman , Von Tengg‐Kobligk Hendrik , Daneshvar Ghorbani Keivan , Siebert Tobias
Published: January 2025

The maintenance of an appropriate ratio of body fat to muscle mass is essential for the preservation of health and performance, as excessive body fat is associated with an increased risk of various diseases. Accurate body composition assessment requires precise segmentation of structures. In this study we developed a novel automatic machine learning approach for volumetric segmentation and quantitative assessment of MRI volumes and investigated the efficacy of using a machine learning algorithm to assess muscle, subcutaneous adipose tissue (SAT), and bone volume of the thigh before and after a strength training. Eighteen healthy, young, female volunteers were randomly allocated to two groups: intervention group (IG) and control group (CG). The IG group followed an 8‐week strength endurance training plan that was conducted two times per week. Before and after the training, the subjects of both groups underwent MRI scanning. The evaluation of the image data was performed by a machine learning system which is based on a 3D U‐Net‐based Convolutional Neural Network. The volumes of muscle, bone, and SAT were each examined using a 2 (GROUP [IG vs. CG]) × 2 (TIME [pre‐intervention vs. post‐intervention]) analysis of variance (ANOVA) with repeated measures for the factor TIME. The results of the ANOVA demonstrate significant TIME × GROUP interaction effects for the muscle volume (F1,16 = 12.80, p = 0.003, ηP2 = 0.44) with an increase of 2.93% in the IG group and no change in the CG (−0.62%, p = 0.893). There were no significant changes in bone or SAT volume between the groups. This study supports the use of artificial intelligence systems to analyze MRI images as a reliable tool for monitoring training responses on body composition.
Expression and function of Connexin 43 and Connexin 37 in the murine zona glomerulosa
Authors: Stölting Gabriel , Hellmig Nicole , Dinh Hoang An , Butz Frederike , Secener Ali Kerim , Volkert Marina , Scholl Ute I.
Published: January 2025

The zona glomerulosa (ZG) synthesizes the mineralocorticoid aldosterone. The primary role of aldosterone is the maintenance of volume and electrolyte homeostasis. Aldosterone synthesis is primarily regulated via tightly controlled oscillations in intracellular calcium levels in response to stimulation. It has previously been shown that calcium oscillations are synchronized through mechanical linkage between adjacent ZG cells. In many other cell types, similar synchronization is rather dependent on gap junctions (GJ). The recent discovery of mutations in CADM1 was linked to impaired GJ function in the ZG. Based on published transcriptomics data, we re‐examined the presence and functional impact of GJ in the ZG. We found evidence for the expression of murine connexin 43 and 37 using microarray data, in‐situ hybridization and immunohistology. Connexin 43 was also present in human samples. Calcium oscillations in ZG rosettes showed some degree of synchronization as reported previously. Unspecific GJ inhibition only had a small impact on this synchronicity. However, no signs of connections between cytosols could be observed as indicated by the lack of fluorescence recovery after photobleaching. We conclude that, while connexin proteins are expressed in the ZG, functional GJ in the physiological ZG are rare and of little consequence for calcium signaling.
Synergistic effect of artificial intelligence and new real-time disassembly sensors: Overcoming limitations and expanding application scope
Authors: Bozhou Li , Dajiang Ju , Xingwang Li , Yan Liu , Hongru He , Hao Wang
Published: January 2025

With the acceleration of industrialization and the increase in the complexity of equipment, it is particularly important to accurately predict and effectively maintain equipment failures. In response to the problem of difficulty in accurately achieving predictive maintenance and the severely limited application range of new real-time disassembly sensors, this article conducts research on the synergistic effect of the new real-time disassembly sensors and artificial intelligence technology. First, relevant parameter data of a certain enterprise’s generator can be collected on-site, and the Pearson correlation coefficient method can be used to calculate the correlation between the generator data parameters and the target fault type, ensuring the degree of correlation in extracting data features. Then, based on the gated recurrent unit (GRU) model, the article applied the particle swarm optimization (PSO) algorithm to optimize the parameters of the GRU network and used the support vector machine (SVM) model to optimize the classification function of the network output. Finally, the optimized GRU model can be applied to predict the fault types of generators, and based on this, it can be applied to the energy industry, agriculture, medical and health, and transportation industries to verify the application scalability of artificial intelligence and new real-time disassembly sensors. The experimental results show that the optimized GRU model combined with the new real-time disassembly sensor achieved an average accuracy of 0.94 in generator fault prediction, with a cost loss rate of only 3.03%, a decrease of 5.91% compared to the single new real-time disassembly sensor. The combination of artificial intelligence technology for precise predictive maintenance of generators greatly reduces maintenance costs and overcomes the limitations of individual real-time sensor disassembly. This has to some extent expanded the application scope and promoted the intelligent development of various industries.
Nanoscale heat generation in a single Si nanowire
Authors: Kim Jungkil , Lee Hoo-Cheol , Park Hong-Gyu
Published: January 2025

We develop a nanoheater utilizing a single Si nanowire with a porous segment that produces localized heat. The 19-fold higher resistivity of the porous segment compared to the solid segment in the nanowire facilitates the substantial confinement of heat to the porous segment by Joule heating. The heat profiles of the nanowire are examined using scanning thermal microscopy, a direct thermal imaging technique. The profiles recorded along the longitudinal and cross-sectional axes of the nanowire reveal that heat is concentrated in the sub-micrometer region of the porous segment, whereas it is uniformly distributed along the whole axis of the homogeneous solid Si nanowire. Moreover, the HfO2-passivated nanowire device exhibits a temperature increase above 10 °C within a 0.4 × 1 μm2 area, which is advantageous compared to the 3.3 °C increase observed in the hBN-passivated device. These point heaters demonstrate considerable potential for future applications in biomedical engineering and optoelectronics.
Time persistence of the fMRI resting-state functional brain networks
Authors: Guo Shu , Levy Orr , Dvir Hila , Kang Rui , Li Daqing , Havlin Shlomo , Axelrod Vadim
Published: January 2025

Time persistence is a fundamental property of many complex physical and biological systems; thus understanding the phenomenon in the brain is of high importance. Time persistence has been explored at the level of stand-alone neural time-series, but since the brain functions as an interconnected network, it is essential to examine time persistence at the network level. Changes in resting-state networks have been previously investigated using both dynamic (i.e., examining connectivity states) and static functional connectivity (i.e., test-retest reliability), but no systematic investigation of the time persistence as a network was conducted, particularly across different time-scales (i.e., seconds, minutes, dozens of seconds, days) and different brain subnetworks. Additionally, individual differences in network time persistence have not been explored. Here, we devised a new framework to estimate network time persistence at both the link (i.e., connection) and node levels. In a comprehensive series analysis of three functional MRI (fMRI) resting-state datasets including both sexes, we established that: a) The resting-state functional brain network becomes gradually less similar to itself for the gaps up to 23 minutes within the run and even less similar for the gap between the days; b) Network time persistence varies across functional networks, while the sensory networks are more persistent than non-sensory networks; c) Participants show stable individual characteristic persistence, which has a genetic component; and d) Individual characteristic persistence could be linked to behavioral performance. Overall, our detailed characterization of network time persistence sheds light on the potential role of time persistence in brain functioning and cognition.

Significance statementTime persistence − how long the system stays in a certain configuration − is a fundamental characteristic property of a variety of complex physical and biological systems. To date, the network time persistence of the brain is not sufficiently well understood. Here, we introduce and test a novel framework to quantify brain network time persistence. We found that the functional brain network becomes gradually less similar within the run (up to 23 minutes) and even less similar between days. The participants showed stable individual characteristic persistence, which has a genetic component. In addition, individual characteristic persistence could be linked to behavioral performance. Thus, brain network time persistence may play a key role in brain functioning and human cognition.
Spectrum and carcinogenic properties of thyroglobulin gene fusions in thyroid
Authors: Schmidt Gavin M , Fornal Ian J , Doerfler William R , Wald Abigail I , Keating Shannon E , Nikiforova Marina N , Nikiforov Yuri E , Nikitski Alyaksandr V
Published: January 2025

Approximately 10–20% of thyroid cancers are driven by gene fusions, which activate oncogenic signaling through aberrant overexpression, ligand-independent dimerization or loss of inhibitory motifs. We identified 13 thyroid tumors with thyroglobulin (TG) gene fusions and aimed to assess their histopathology and the fusions’ oncogenic and tumorigenic properties. Of eleven cases with surgical pathology, 82% were carcinomas and 18% were noninvasive follicular thyroid neoplasms with papillary-like nuclear features (NIFTP). TG fusions preserved exon(s) 1, 1–15, 1–35 or most frequently, 1–47 of TG and, based on the 3′ partner were grouped as i) involving receptor tyrosine kinases (RTKs) (TG::FGFR1, TG::RET, TG::ALK and TG::NTRK1), ii) driving aberrant DPRX and chromosome 19 microRNA cluster expression (TG::DPRX) or iii) involving IGF2 mRNA-binding protein (TG::IGF2BP1). All 13 fusion-positive tumors exhibited strong (8.5 ± 3.3 log2-fold) 3′ partner overexpression driven by the TG promoter. Gene expression analysis revealed TG::RET- and TG::ALK-positive tumors being BRAFV600E-like and remaining tumors RAS-like. In thyroid PCCL3 cells, the TG::NTRK1 fusion demonstrated both spontaneous and ligand-associated dimerization, activated downstream MAPK, AKT and STAT3 signaling and drove xenograft tumorigenesis in nude mice. FDA-approved NTRK inhibitors entrectinib and larotrectinib effectively blocked TG::NTRK1 signaling in vitro and inhibited xenograft tumor growth in vivo. In summary, we report a spectrum of TG gene fusions as recurrent oncogenic events in thyroid cancer and NIFTP that drive strong overexpression of partner genes, frequently RTKs. The TG::NTRK1 fusion is prone to dimerization, activates oncogenic signaling, drives tumorigenesis in thyroid cells and, like other fusions involving RTKs, represents a potential therapeutic target in thyroid cancer.
АНАЛИЗ СИНЕРГЕТИЧЕСКОГО НАЗЕМНОГО МКВ + ИК-МЕТОДА ОПРЕДЕЛЕНИЯ ВЕРТИКАЛЬНЫХ ПРОФИЛЕЙ СОДЕРЖАНИЯ ОЗОНА
Authors: БОРДОВСКАЯ Ю.И. , ТИМОФЕЕВ Ю.М. , ВИРОЛАЙНЕН Я.А. , ПОБЕРОВСКИЙ А.В.
Published: January 2025

Озон является одним из важнейших малых газовых составляющих атмосферы Земли. В данной работе анализируется наземный синергетический МКВ + ИК-метод измерения содержания озона с использованием функционирующих в Петергофе (СПбГУ) приборов: МКВ-озонометра и ИК-Фурье-спектрометра Bruker IFS 125HR. Вычислены погрешности дистанционных измерений озона, которые меняются от 5 до 20% и более. Вертикальное разрешение МКВ + ИК-метода варьируется от ~ 10 до ~ 12 км. Представленные оценки показывают потенциальные возможности определения содержания озона в Петергофе с помощью наземных комбинированных МКВ- и ИК-измерений.

Ozone is one of the important trace gases of the Earth's atmosphere. This study anal yses ground-based synergetic MW + IR method for remote measurements of ozone using ground-based instruments at Peterhof (SPbSU) - MW ozonometer and Bruker IFS-125HR Fourier transform infrared spectrometer. Numerical estimates of the errors and vertical resolution of remote measurements showed that uncertainties of remote ozone measurements at different altitudes vary from 5 to 20% or more. The vertical resolution of the MW + IR method varies from ~ 10 to ~ 12 km. These estimates demonstrate the potential for determining ozone in Peterhof using ground-based combined MW and IR measurements.
СРАВНИТЕЛЬНАЯ ХАРАКТЕРИСТИКА ВЕРТИКАЛЬНОГО РАСПРЕДЕЛЕНИЯ ИНТЕНСИВНОСТИ БИОЛЮМИНЕСЦЕНЦИИ В СЕВЕРО-ЗАПАДНОЙ И СЕВЕРО-ВОСТОЧНОЙ ЧАСТЯХ ЧЕРНОГО МОРЯ
Authors: ПОЛОНСКИЙ А.Б. , МЕЛЬНИКОВА Е.Б. , СЕРЕБРЕННИКОВ А.Н.
Published: January 2025

Представлены результаты анализа пространственно-временного распределения интенсивности свечения гидробионтов в Черном море на основе данных экспедиционных исследований, проведенных в июне 2013 г. и сентябре 2014 г. в рейсах НИС «Профессор Водяницкий». Сравнивается вертикальное распределение интенсивности биолюминесценции в северо-западной и северо-восточной частях Черного моря. Для объяснения причин пространственно-временных вариаций интенсивности свечения гидробионтов привлекаются спутниковые данные о приводном ветре и геострофических течениях. Показано, что в вертикальном распределении интенсивности биолюминесценции на большинстве станций наблюдался один максимум, который находился в верхней части сезонного термоклина. На глубоководных станциях в северо-западной части моря, приуроченных к зоне слабых вертикальных движений, наблюдались два максимума. Верхний максимум обусловлен развитием теплолюбивых, а нижний - холодолюбивых комплексов гидробионтов. Максимальные величины интегральной интенсивности свечения гидробионтов наблюдались в зоне дивергенции течений в глубоководной части северо-восточной акватории моря, что объясняется более активным обогащением вод биогенными веществами за счет более интенсивных восходящих движений. Полученные результаты могут быть использованы для уточнения оценки биопродуктивности деятельного слоя вод Черного моря на основе спутниковых данных.

The spatiotemporal distribution of the intensity of bioluminescence formed by hydrobionts in the Black Sea based on the data of expeditionary research conducted in June 2013 and September 2014 during the voyages of NIS “Professor Vodyanitskiy" (IBSS) was investigated. Comparison of this characteristic in the N-W and N-E parts of the Black Sea has been done. Satellite data on near-surface wind and geostrophic currents are used to explain the causes of spatiotemporal variations in the intensity of hydrobiont bioluminescence. It has been shown that in the vertical distribution of bioluminescence intensity, most stations had one maximum at the top part of the seasonal thermocline. At deep-sea stations in the north-western part of the sea located in the zone of weak vertical movements, two maxima were observed due to the development of heat-loving hydrobiont species in the upper maximum and cold-loving species in the lower one. The maximum values of the integral intensity of hydrobiont glow were observed in the divergence zone in the deep-water north-eastern part of the sea, which is explained by more active enrichment of waters with biogenic substances due to more intense upward movements. Obtained results can be utilized for more accurate assessment of the upper layer water bioproductivity in the Black Sea from satellite data.
Projective Maximality on H-closed extensions of Hausdorff Spaces
Authors: Serrato Vargas Sandra , Ordoñez Delgado Bartleby
Published: January 2025

Este artículo contiene una visión moderna del estudio de las extensiones H-cerradas de un espacio de Hausdorff X. Se plantean varias preguntas: ¿Cómo se pueden construir extensiones H-cerradas? ¿Es posible comparar estas extensiones? De ser así, ¿existe una extensión maximal? Se responde afirmativamente a estas preguntas, demostrando que la extensión de Katětov es la extensión H-cerrada maximal buscada. Además, se presentan aplicaciones a la teoría de extensión de funciones y espacios HČ-completos.
Modelos predictivos en la clasificación de donantes a plaquetoféresis sanguínea en el Hospital Nacional Edgardo Rebagliati Martins, Lima-Perú. 2022
Authors: Morales Del Pino Jimmy Rinaldo , Norabuena Figueroa Roger Pedro
Published: January 2025

The objective of the present investigation was to determine the predictive model that allows classifying donors for blood plateletpheresis at the Edgardo Rebagliati Martins-EsSalud National Hospital, Lima-Peru 2022, using a database of donors who came to donate platelets through plateletpheresis in the period 2015-2022. A descriptive, retrospective, and non-experimental research design was used. To evaluate the predictive models, the Python programming language was used using Google Colab, where the stages that involve the construction of a Machine Learning model were carried out, finding that the decision tree was the model with the best performance both when using unbalanced data (Precision=0.89; F1-Score=0.91; AUC=0.90) as balanced data using SMOTE (Precision=0.87; F1- Score=0.89; AUC=0.90), having a better predictive capacity in the classification of platelet donors versus other models.
A repeated case of neonatal sepsis in one family: coincidence or unfortunate pattern?
Authors:   Shupyk National Healthcare University of Ukraine, Kyiv, Kostiuk O.O. , Shunko Ye.Ye. ,   Shupyk National Healthcare University of Ukraine, Kyiv, Bugar V.V. ,   Kyiv Maternity Hospital No.1, Ukraine, Goncharuk N.P. ,   Kyiv Maternity Hospital No.1, Ukraine
Published: January 2025

Neonatal sepsis still remains an extremely relevant problem for newborns and a challenge for neonatologists and continues to take one of the prominent places of neonatal morbidity and mortality worldwide. The causes of neonatal sepsis are multifactorial and may have both maternal and other, unexplained causes. In recent years, numerous studies have been focused at studying the relationship between genetic variations and the frequency and causes of neonatal sepsis. Research are still continuous for study the role of genes associated with the formation of the inflammatory response in newborns. Research the role of genes associated with the formation of an inflammatory response in newborn children continues.
Aim - to provide substantiated information on the problem of the features of the clinical course of neonatal sepsis with an analysis of literature data on possible genetic determinants of the occurrence of this disease in newborns using the example of a specific clinical case.
The article presents a clinical case of fulminant sepsis in a newborn baby with a fatal outcome, which occurred repeatedly in the same family over two years with a similar clinical features and outcome. The authors tried to analyze the peculiarities of the neonatal sepsis, diagnostic procedures, treatment methods, causes of death and to link clinical and diagnostic findings with possible genetic disorders. The presented clinical case suggests the need for more in-depth studies involving geneticists and other specialists to predict the health of married couples and their future children.
Conclusions. Identification of variations in genes involved in the bacterial-induced cellular response, as well as in the pathogenesis of sepsis, may allow the development of new diagnostic tools, improve the classification of sepsis, and more accurately predict the results of treatment in patients. Considering the mother's history, the course of the disease in the newborn, and the available clinical and laboratory examination data, a comprehensive in-depth genetic study of this married couple is mandatory.
The study was carried out in accordance with the principles of the Declaration of Helsinki. The informed consent of the children's parents was obtained for the research.
No conflict of interests was declared by the authors.
Osteochondrodysplasia: punctate chondrodysplasia (а literature reference and own clinical case)
Authors:   Donetsk National Medical University, Lуman, Ukraine, Khapchenkova D.S. , Momot M.S. ,   Donetsk National Medical University, Lуman, Ukraine, Dubyna S.O. ,   Donetsk National Medical University, Lуman, Ukraine
Published: January 2025

Osteochondrodystrophies belong to the group of perixsomal diseases. Punctate chondrodysplasia is a genetic disorder of connective tissue, accompanied by the formation of punctate calcifications in the epiphyses, areas of the bone growth plate and in periarticular tissues, followed by shortening of the limbs, the development of flexion contractures and deformities of the feet and curvature of the spinal column. Foci of calcifications can be visualized using fetal ultrasound and radiography during the neonatal and infancy period. The clinical symptoms of this pathology are different, depending on the number of organs and systems involved in the pathological process. The diagnosis is based on the study of genealogical history, clinical manifestations, data from laboratory and instrumental research methods, DNA diagnostics. Treatment of the above pathology is syndromic. Osteochondrodysplasia is an example of a severe hereditary pathology, the prevalence of which tends to increase. Genetic heterogeneity and polymorphism of clinical symptoms indicate the need for an in-depth and detailed study of such diseases, the features of their metabolic disorders and their consequences in patients.
Aim - to present a clinical case of a patient with punctate osteochondrodysplasia, as an example of the need for constant palliative care.
Clinical case. Multiple malformations in a child are diagnosed prenatally, confirmed after birth. The boy's condition from birth is hard, the boy has no spontaneous breathing since birth, attempts at non-invasive artificial lung ventilation were unsuccessful. The child underwent a lower tracheostomy for further long-term invasive ventilation to sustain life. Throughout his life, the patient will need multidisciplinary supervision by doctors, long-term antibiotic therapy for the prevention of secondary bacterial infection, periodic sanitation of the tracheobronchial tree.
Conclusions. Patients with osteochondrodysplasia almost always have a serious condition. Children with osteochondrodysplasia need specialized lifelong care, taking into account the individual manifestations of the disease and the needs of the child.
The research was carried out in accordance with the principles of the Helsinki Declaration. The informed consent of the patient was obtained for conducting the studies.
No conflict of interest was declared by the authors.
Comprehensive analysis and quantitative assessment of land use/land cover dynamics in Wakiso and Kampala, Uganda: a multi-decadal remote sensing study.
Authors: Kamukama Ebaju Gerverse , Okrah Abraham , Genesis Magara , Mensah Caleb , Donnata Alupot , Prempeh Nana Agyemang , Yeboah Emmanuel , Sarfo Isaac
Published: January 2025

Aim of the study

This study analyses LULC changes in Wakiso and Kampala districts from 1995 to 2024. Objectives include mapping LULC types, assessing changes, evaluating transitions among categories (agriculture, water, built-up areas, forests), and examining trends and drivers. It provides insights into the impacts of urbanization and agricultural expansion, offering practical implications for sustainable land management.

Material and methods

Landsat images from 1995, 2010, and 2024 were used, sourced from NASA's Earth Explorer. January images minimized seasonal variation, and data were reprojected to UTM Zone 36N with WGS84. Pre-processing included corrections and haze reduction in ArcMap 10.4. Supervised classification used a False Colour Composite of blue, green, and red bands, with 2,500–3,000 pixels per LULC category sampled. Accuracy was assessed with Kappa statistics and overall accuracy, and NDVI and NDBI were calculated for vegetation and urban growth analysis.

Results and conclusions

The analysis showed significant land use changes: built-up areas increased by 163%, reducing vegetation cover by 30.7%. Agricultural land grew by 112.4%, while forest cover rose by 29.2%. NDVI trends revealed a vegetation density increase until 2010, then a slight decline by 2024 due to urban sprawl. NDBI showed substantial urban growth, stabilizing between 2010 and 2024. The study highlights the impact of urbanization and agricultural expansion in Wakiso and Kampala, emphasizing the need for sustainable land management to balance development and conservation.
Michael and Sybil Brown: Food and Wine of South West France
Authors: Davidson Alan E
Published: January 2025

Michael and Sybil Brown: Food and Wine of South West France: Batsford, London, 1980: 240 pp., maps, 12 colour photographs, £12.50.
Latency, sleep hours, and blood pressure in hospitalized patients in Mexico
Authors:   Universidad Autónoma de Tamaulipas, Tampico Faculty of Nursing. Tamaulipas, México, Pérez-Vega María Elena , Aguirre-González Ma. Elena , Amaro-Valdez Tania , Morelos-García Edgar Noé , Reséndiz-González Eunice , Lara-Pérez Ricardo
Published: January 2025

Introduction: Multiple studies have associated sleep duration and quality with changes in blood pressure in the general population, considering it a related risk factor. However, there is limited information regarding hospitalized patients who tend to experience sleep disturbances. Objective: To examine the relationship between subjective sleep duration, sleep latency, and systolic and diastolic blood pressure in hospitalized patients. Materials and Methods: A cross-sectional study included 381 Mexican adults hospitalized in a secondary-level hospital in Tampico, Tamaulipas, Mexico. Self-reported sleep duration and latency were assessed using the Pittsburgh Sleep Quality Index component. Clinical and sociodemographic data were collected. The study was approved by an ethics committee. Results: In adjusted models, a significant negative association was found between subjective sleep hours and diastolic blood pressure (β= -0.59; 95% CI: -1.80 to -0.10). A significant positive relationship was observed between sleep latency and systolic blood pressure (β= 1.48; 95% CI: -0.49 to 2.47). Discussion: The findings are consistent with those of previous studies. Hospitalization can impact sleep due to unfamiliar environments, noise, irregular schedules, and invasive procedures, affecting patients' health and prognosis. Conclusions: It is essential to consider sleep as a modifiable factor in preventing and managing hypertension in hospitalized patients and to find effective interventions to improve sleep duration and quality.
Content validation of a questionnaire on healthcare personnel's perceptions of technologies
Authors:   Corporación Universitaria Minuto de Dios-UNIMINUTO, Bogotá, Colombia, Díaz Rincón Maritza , Arango Franco Paula Constanza , Vergel Torrado Jose Alejandro , Lora Díaz Olga Lucia
Published: January 2025

Introduction: Across the world, multiple institutions in the health sector actively promote the adoption and expansion of health technology innovations, driven by their potential benefits in improving medical care quality. The successful integration of health technologies into healthcare settings brings significant changes to work activities and depends, in part, on their acceptance and appropriation by healthcare personnel. Objective: To determine the content validity of a questionnaire adapted to assess perceptions and attitudes toward health technologies. Materials and Methods: Content validity was assessed through expert judgment using the model proposed by Escobar and Cuervo (2008). A 28-item questionnaire was adapted to assess health personnel's perceptions and attitudes toward technologies, and content validity was determined using Aiken's V coefficient. The Brennan and Prediger coefficient was used to assess agreement among experts. Results: The Aiken V coefficient was 0.98 (95% CI: 0.88 - 1.00) for the entire instrument. The expert agreement was almost perfect. Discussion: Most of the studies evaluating perceptions and attitudes toward technologies do not include validation through expert judgment before conducting statistical validation. Conclusions: According to the criteria of the consulted experts, the questionnaire's content validity is acceptable for assessing perceptions and attitudes toward health technologies.
National adaptive social well-being index for measuring regional disparities in Kazakhstan
Authors:   Institute of Economics of the Science Committee of the Ministry of Science and Higher Education of Kazakhstan, Almaty, Kazakhstan, Satybaldin Azimkhan A. , Moldabekova Aisulu ,   Institute of Economics of the Science Committee of the Ministry of Science and Higher Education of Kazakhstan, Almaty, Kazakhstan, Alibekova Gulnaz Zh. ,   Institute of Economics of the Science Committee of the Ministry of Science and Higher Education of Kazakhstan, Almaty, Kazakhstan, Azatbek Tolkyn ,   L. N. Gumilyov Eurasian National University, Astana, Kazakhstan
Published: January 2025

Relevance. The well-being of citizens is a key focus of national policies worldwide. Kazakhstan, however, is characterized by significant regional disparities in social well-being, which necessitates targeted programs and investments to improve conditions in less developed areas.
Research Objective. This study aims to develop a national adaptive social well-being index to evaluate and spatially map the regions of Kazakhstan.
Data and Methods. The methodology included identifying indicators through a literature review and regional data, conducting an expert survey to weight them, and creating a social well-being index. A spatial analysis was then used to calculate the index for each region.
Results. The social well-being index shows significant disparities across regions. Astana, Almaty, and Atyrau demonstrate strong social welfare, driven by economic growth and advanced social infrastructure. In contrast, Karaganda, Pavlodar, and Shymkent show lower social welfare, highlighting the need for targeted interventions and investments.
Conclusion. The findings offer valuable insights for policymakers to design strategies for sustainable socioeconomic growth in Kazakhstan. The proposed index can help national and regional authorities monitor social well-being.
Key factors in managing creative reindustrialization strategies
Authors:   Ural Federal University, Ekaterinburg, Russian Federation, Derbeneva Valentina V. , Baskakova Irina V. ,   Ural Federal University, Ekaterinburg, Russian Federation, Chukavina Kristina V. ,   Ural Federal University, Ekaterinburg, Russian Federation, Turgel Irina D. ,   Ural Federal University, Ekaterinburg, Russian Federation, Novokshonova Zlata V. ,   Ural Federal University, Ekaterinburg, Russian Federation, Tsepeleva Alena D. ,   Ural Federal University, Ekaterinburg, Russian Federation
Published: January 2025

Relevance The growing importance of creative industries in Russia's economy underscores the need for effective management strategies to support the reindustrialization of second-tier cities, with a focus on socio-economic growth and the preservation of local identity.
Research Objective The article aims to identify key factors that influence the development and implementation of creative reindustrialization strategies in second-tier cities.
Data and Methods Using econometric modeling, the study analyzed data from 50 industrial cities in Sverdlovsk and Chelyabinsk regions (2010–2024), sourced from the Federal State Statistics Service, the Ministry of Construction, Housing and Utilities, and the Presidential Grant Foundation.
Results. The study identified key factors contributing to the growth of creative industries, including the expansion of creative sector companies, proximity to regional centers, increased grant applications, the presence of manufacturing enterprises, growth in local government revenue, and the development of new housing. A comprehensive set of government support measures was proposed, encompassing infrastructure development, financial assistance, educational initiatives, informational resources, and regulatory improvements.
Conclusions Essential government support to creative industries should include infrastructure development, simplified administrative procedures, tax incentives, institutional and legislative backing, and export promotion. Other support measures can be tailored to the chosen management strategy and regional needs, resulting in the creation of a flexible system centered around local identity.
“A Home-School for Everyone”. Transcultural Identity in Education as a Chance for Formation of School Transcultural Communities
Authors: Lisowska Kinga
Published: January 2025

Europe and the world have recently changed their political, economic and socio-cultural face. Migration movements caused by many factors, like SARS-CoV-2 or Russia’s attack on Ukraine, have destabilized the system of social structures in the macro and micro space, including groups and various communities. At the same time, progressive digitalization has led to an easy and rapid blurring of the boundaries between the cultures represented in the home and school environments of children and young people. From the perspective of these changes, on the one hand, the threat of marginalization of students identifying with different cultures has increased, and the use of stereotypes that have prevailed so far causes exclusion due to ethnic, national or religious diversity. On the other hand, the way has opened up for the formation of societies, including transcultural groups and communities, which makes it possible to come to terms with the dynamics of cultures and construct new transcultural structures devoid of antagonisms. The presented article attempts theoretical considerations on the essence of shaping transcultural identity among children and young people, introduced at school through education for acculturation, and leading to the creation of a transcultural school community open, ensuring safety for all differences and focused on creating new connections. In these considerations, transcultural identity was considered an "opportunity" for the school’s new tasks to ensure the functioning of students in a culturally diverse, open, non-marginalizing school transcultural community.
What Kind of Education in Times of Climate Migration?
Authors: Cywiński Aleksander
Published: January 2025

The climate and environment emergency caused by human-generated greenhouse gas emissions presents significant global challenges, including rising temperatures, extreme weather conditions, and sea level rise. These effects impact agriculture, water resources, human health, and biodiversity, while also exacerbating socio-economic vulnerabilities. Climate migration, driven by these environmental changes, will reshape societies and challenge access to education for displaced populations. In response, education systems must adapt, promoting environmental justice, inclusivity, and resilience, while equipping future generations with the skills needed for a sustainable future.
Entrepreneurial Education Profiles of Students from the Czech Republic, Poland and Slovakia
Authors: Sołtysiak Wioletta
Published: January 2025

The aim of this article is to know the opinions of students of pedagogical studies in terms of their self-assessment of selected competences that can form the profiles of entrepreneurial groups. The argument consists of two parts. The first one is the review of literature on the terminology of competences. The second part covers the presentation of the results of (preliminary) own research in groups of full-time students, conducted by a survey method using a questionnaire survey. The research covered students from the Czech Republic, Slovakia and Poland. Entrepreneurial competences were divided into three groups: ‘Ideas and capabilities’, “Resources” and “Action”, according to the document The Entrepreneurship Competence Framework(2020). The research showed that Polish students have most entrepreneurial characteristics, especially in terms of the traits in the group “Resources” and “Action”. Students from the Czech Republic mainly attributed themselves characteristics from the “Action” area. Students from Slovakia are to a small extent aware of possessing their entrepreneurial qualities.
The peasantry and national identity in the context of Czech ruralism
Authors: Derková Vladimíra
Published: January 2025

Since the National Revival in the 19th century the portrayal of the countryside and its inhabitants as bearers of traditional and folk values in Czech literature has been closely linked to the portrayal of national identity. The paper aims to analyse links between the countryside, the peasantry, and national identity within the context of Czech ruralism.
Náboženská symbolika ve službách expresionistického dramatu
Authors: Merenus Aleš
Published: January 2025

Studie Náboženská symbolika ve službách expresionistického dra-matu představuje na vybraných českých a německy psaných expresionistických hrách způsoby, jimiž expresionističtí dramatici desátých a dvacátých let minulé-ho století působící v geografickém prostoru českých zemí transformovali původně křesťanské náboženské motivy a symboly v symboly nové estetické religiozity a sociální revoluce.
Čehizmi u slovačkom jeziku iz normativnoga aspekta
Authors: Grčević Martina
Published: January 2025

Leksemi preuzeti iz češkoga u slovačkom standardnom jeziku mogu se razvrstati u tri skupine: 1) u skupinu adaptiranih leksema proizišlih iz slovač-ko-čeških jezičnih dodira koji pripadaju slovačkomu standardnomu jeziku, 2) u sku-pinu leksema koji se u nekom razdoblju pojavljuju kao rubni elementi u slovačkom, no koji nisu ušli u širu uporabu, odnosno koji se u njoj nisu zadržali, i 3) u skupinu leksema koji u slovačkoj jezičnoj praksi konkuriraju slovačkim riječima, no koji u normativistici nisu prihvaćeni kao dio slovačkoga standardnoga jezika. U ovom se radu opisuju normativni status i normativne mijene čehizama ponajprije na primjeru najnovijih izdanja Kratkoga rječnika slovačkoga jezika, koji je prema slovačkomu Ministarstvu kulture i Zakonu o državnom jeziku Slovačke Republike mjerodavan kodifikacijski priručnik.
Diskurzní markery: k otázce slovního přízvuku
Authors: Jílková Lucie
Published: January 2025

Tématem tohoto článku jsou víceslabičné diskurzní markery (dále DM) a jejich potenciální ztráta slovního přízvuku. Článek odpovídá na tyto výzkum-né otázky: Mohou víceslabičné diskurzní markery ztrácet přízvuk? Kolikaslabičné takty diskurzní markery (spolu)vytvářejí?Analýza ukázala, že z celkového počtu 44 přízvukových taktů, v nichž se DM ob-jevily, tvořily celý přízvukový takt ve 13 případech (např. | síla to najít | teda | ). V jednom případě pak tvořily přízvukový takt dva DM ( | fakt ty jo | dobrý | ). Ve všech ostatních případech se DM staly součástí víceslabičného přízvukového taktu; často se připojují k předcházejícím slovu, čímž ztrácejí slovní přízvuk. Nejdelší za-chycené přízvukové takty, jehož součástí byly dvojslabičné DM, měly sedm slabik (např. | něco | přirozenýho že jo | ). Velmi běžně se DM stávaly součástí taktů čtyř- a tříslabičných (např. | tim se cvičí | mozek že jo |; | člověk | přemejšlí a | nic ty jo | ). Častěji se objevovaly případy, v nichž se DM připojovaly k předchozímu slovu, DM však mohou stát i na začátku víceslabičných taktů (např. | ty jo to je | síla | ).