bluuebunny/crossref_metadata_2025 huggingface dataset:
ANÁLISE DO EFEITO ANTIOXIDANTE HEPÁTICO DA MACROALGA Kappaphycus alvarezii ADICIONADA NA DIETA
Authors: Venâncio Stefany de Mira , Schroeder Gabriela Sangalli , Valentini Fernanda Danieli Antoniazzi , Petrolli Rafaella Rossetto , Terranova Izabel Carolina Bousfield , Petrolli Tiago Goulart , Milarch Carine de Freitas
Published: December 2024

A fitoterapia está presente na sociedade desde os tempos primórdios com as primeiras descobertas sobre plantas e ervas que eram usadas para o tratamento de patologias diversas. Dentro deste contexto, a macroalga Kappaphycus alvarezii destaca-se por sua composição rica em alcalóides, glicosídeos, flavonóides, esteróides e compostos fenólicos e assim, torna-se uma candidata em potencial para análise dos efeitos de compostos fitoquímicos na ação antioxidante hepática, objetivo do presente estudo. Trata-se de uma pesquisa experimental com abordagem quantitativa, que foi realizada em 2 experimentos para melhor avaliação dos extratos vegetais obtidos da macroalga em estudo. No experimento I, os extratos da alga foram obtidos e testados para capacidade antioxidante total e compostos fenólicos. Após a escolha dos extratos de composição em destaque, foi realizado o experimento II, onde os extratos da alga foram adicionados na ração de O. niloticus (~10,32 ± 7,54 g; 5 ± 3,5 cm), distribuídos em 5 grupos (n=6), em duplicata, sendo 5 tratamentos com diferentes concentrações dos extratos escolhidos e 1 grupo controle, contendo apenas a dieta basal. Nesse contexto, após 30 dias de experimento, foram preparadas amostras de fígado para avaliar enzimas antioxidantes (superóxido dismutase  e glutationa-S-transferase) e danos às proteínas (carbonilação protéica) e ácido tiobarbitúrico (TBARS). Diante do exposto, considerando que o fígado é um órgão complexo e de extrema importância para a homeostase corporal, nota-se que a introdução de extratos de alga na dieta promoveu o potencial antioxidante hepático ocasionando possível redução de radicais livres.
Rehabilitation Following Repairs of the PCL, MCL, and Medial Meniscus Root in a Collegiate Football Player
Authors: Joreitz Rick , Lott Ariana , Hughes Jonathan , Herrman Elizabeth , Musahl Volker
Published: December 2024

BACKGROUND: Little evidence exists regarding the return-to-sport outcomes of American football players following multiligament knee injuries (MLKIs), specifically following an injury that does not include the anterior cruciate ligament (ACL).

CASE PRESENTATION: The patient is a 22-year-old American football offensive lineman, who sustained posterior cruciate ligament (PCL), medial collateral ligament (MCL), and medial meniscus root tears.

OUTCOME AND FOLLOW-UP: The patient underwent surgery to repair the PCL, MCL, and medial meniscus root tears. The patient completed physical therapy and was able to return to his prior level of function, playing collegiate football 11 months after surgery.

DISCUSSION: This case highlights the decision-making process of the sports medicine team regarding the diagnosis and management of the acute injury and details the surgical, rehabilitation, and return-to-sport processes following an MLKI that does not include the ACL. JOSPT Cases 2025;5(1):1-11. Epub 12 December 2024. doi:10.2519/josptcases.2024.0075
СОЗРЕВАНИЕ ООЦИТОВ КРУПНОГО РОГАТОГО СКОТА МОДИФИКАЦИЯ МЕТОДИКИПРИМЕНЕНИЕМ РЕКОМБИНАНТНОГО ФОЛЛИКУЛОСТИМУЛИРУЮЩЕГО ГОРМОНА ЧЕЛОВЕКА
Authors: И. Г. Сметанина , Л. В. Татаринова , А.С. Кривохарченко
Published: December 2024

Цель работы - изучить эффективность созревания ооцитов крупного рогатого скота in vitro в безбелковой среде MEM-α, дополненной двумя различными препаратами фолликулостимулирующего гормона (полученного из свиных гипофизов и рекомбинантного человеческого ФСГ). Критерием успешного созревания считали способность ооцитов после оплодотворения развиваться до стадии морулы-бластоцисты и бластоцисты. Показано, что ооциты, созревавшие в присутствии рекомбинантного человеческого гормона, лучше развивались до стадии морулы-бластоцисты (в процентах от дробившихся эмбрионов), и этот эффект сохранялся при развитии до стадии бластоцисты. Заключили, что рекомбинантный ФСГ человека может использоваться для созревания ооцитов крупного рогатого скота in vitro наравне с “классическим” гормоном, полученным из свиных гипофизов.

The aim was to study the efficiency of maturation of bovine oocytes in vitro in a protein-free medium MEM-alfa supplemented by two various preparations of follicle stimulating hormone, isolated from pig pituitary glands and recombinant. The development of in vitro maturated and fertilized oocytes to morula-blastocyst stage and to blastocyst stage was considered as criterion of successful maturation. It has been shown that oocytes matured in the presence of recombinant human hormone developed better to the morula-blastocyst stage (as a percentage of divided embryos), and this effect was maintained during development to the blastocyst stage. It was concluded that recombinant human FSH can be used for the maturation of cattle oocytes in vitro along with the “classical” hormone obtained from porcine pituitary glands.
ВКЛАД ГАПЛОТИПОВ В ФОРМИРОВАНИЕ ПЛЕМЕННЫХ И ВОСПРОИЗВОДИТЕЛЬНЫХ КАЧЕСТВ ЖИВОТНЫХ
Authors: Яковлев А.Ф.
Published: December 2024

В последние десятилетия наблюдаются серьёзные проблемы с репродуктивной функцией коров. Был открыт ряд летальных гаплотипов, связанных с рецессивными расстройствами воспроизводства и других признаков. Частота вредных аллелей, переносимых производителями, возрастает в последовательных генерациях. Разработан ряд методов сканирования генома для оценки биоразнообразия внутри и между породами. Полученные карты неравновесного сцепления генов с высоким разрешением и детали этих карт внесли большой вклад в понимание природы сложных сетей связей между генами гаплотипов и формированием фенотипических признаков. Разработка многоаллельной расчётной модели позволила учитывать вклад каждого гаплотипа в качестве аддитивной и доминантной переменной для геномного прогноза и оценки племенных качеств животных. Митохондриальная ДНК влияет на признаки скорости роста, качества продукции и плодовитости. Гаплотипы мтДНК играют важную роль в репродуктивной функции млекопитающих на этапах созревания яйцеклеток, развития эмбрионов и формирования хозяйственных признаков в постнатальные периоды. Следы интрогрессии в геноме современных пород животных, вызванные искусственным отбором, проявляются в признаках осложнений отёлов, дефектов конституции, эффективности использования корма и фертильности. Различия между микро и макрохромосомами у птиц по неравновесному сцеплению генов объясняются разной скоростью рекомбинации, а различия в дифференцировке генотипа более высокой частотой мутаций в микрохромосомах. Изучение гаплотипов в геномах животных имеет важное значение для понимания вариаций их влияния на формирование фенотипа, на этиологию и патогенез заболеваний. Так, генетическая вариабельность локуса IL8 у коров ассоциируется с проявлением межпородных и индивидуальных различий по иммунитету и устойчивости к инфекции. Обнаружение и идентификация предковых гаплотипов способствуют анализу эволюционной динамики различных популяций, а также выявлению геномных областей для использования в селекции
Генетическая изменчивость и функциональные различия толл - подобных рецепторов (обзор)
Authors: Новак К. , Калашников А.Е. , Калашникова Л.А. , Ялуга В.Л. , Селькова И.В. , Захаров В.М.
Published: December 2024

Исследование генетических факторов, влияющих на состояние здоровья высокопродуктивных животных, может открыть новые пути решения в борьбе с болезнями, вызываемых микробными и вирусными патогенами. Структурное разнообразие толл-подобных рецепторов (TLR), как наиболее часто исследуемых факторов врождённого иммунитета, изучается у всех основных видов животных. Основные разделы обзора: генетическое разнообразие TLR; значение сведений о полиморфизме TLR для успешной борьбы с болезнями животных; перспективы изучения TLR в селекции животных. Выявленные частоты и группировки гаплотипов отдельных полиморфизмов TLR используются для отслеживания происхождения этих изменений как независимых индикаторов функциональных изменений. Выявлены варианты TLR, ассоциированные с маститом и микобактериальными инфекциями у крупного рогатого скота, поэтому применение данных генотипирования при разведении может быть использовано в программах селекции животных на устойчивость к болезням. Выявленные ассоциативные закономерности указывают на то, что повышение врождённой устойчивости возможно для большого числа видов животных. Поэтому традиционные породы и аборигенные популяции животных следует рассматривать как ресурсы генетического разнообразия, применимые для выведения новых пород животных, устойчивых к заболеваниям и влиянию производственных факторов.

ABSTRACT. The exploitation of the genetic factors affecting the health status of farm animals represents an alternative approach to controlling the diseases caused by microbial pathogens. The determination of innate immunity based on the genotype of the germplasm cells is a constraint for specificity but becomes an advantage in breeding schemes. The structural deviations among Toll-like receptors (TLRs), as the most frequently studied innate immunity components, have been documented at all levels, i.e., interspecific, inter- and intravarietal, in the main farm species. The current computational methods facilitate the prediction of the functional consequences of the observed mutations. Subsequently, these predictions can be verified through immunological responsiveness and population-wide association studies. The frequency and haplotype grouping of individual polymorphisms are used to track the origin and selection coefficient as independent indicators of functional changes. The Toll-like receptor variants associated with mastitis and mycobacterial infection have been identified in cattle, consequently, the targeting of these proteins in breeding could contribute to disease control. The range of infections affected by TLR polymorphisms suggests that the improvement of innate resistance is feasible in more species. Thus, the traditional breeds and wild populations should be regarded as the resources of genetic variability accessible for these purposes.
МОНИТОРИНГ АЛЛЕЛОФОНДА ГРУПП КРОВИ ГОЛШТИНИЗИРОВАННОЙ ЧЁРНО-ПЕСТРОЙ ПОРОДЫ КРУПНОГО РОГАТОГО СКОТА
Authors: Шаталина О.С. , Ярышкин А.А. , Лешонок О.И.
Published: December 2024

На основе мониторинга аллелофонда групп крови у современных пород высокопродуктивного молочного скота можно осуществлять отбор селекционного материала с последующим закреплением удачных сочетаний на большом поголовье потомков. Цель исследования – изучить особенности аллелофонда у коров голштинизированной чёрно-пестрой породы крупного рогатого скота и его изменения в период 2013-2018 г.р. на трёх племенных предприятиях Свердловской области (Патруши, Белореченский и Глинский). Определение аллелофонда ЕАВ-системы групп крови проведено с использованием гемолитических тестов; животные были аттестованы по группам крови и по происхождению (n=1812). Рассчитана частота встречаемости каждого аллеля, унаследованного по отцовской, материнской линии и по аллелофонду в целом. Выявлено, что маркерами голштинизированной чёрно-пестрой породы являются аллели G2Y2E'1Q' и I2. Данные аллели имели наибольшую частоту встречаемости со стороны и отца, и матери; частота встречаемости превышала 10% и в отдельных случаях достигала 45%. Количество аллелей со стороны отца составило 19-21 на популяцию племенного предприятия, и со стороны матери – 20-22. Спектр неинформативных аллелей варьирует от трех до 13 аллелей на популяцию.

ABSTRACT. Based on the monitoring of the allele pool of blood groups in modern breeds of highly productive dairy cattle, it is possible to select breeding material with subsequent consolidation of successful combinations on a large number of descendants. The aim of the work was to study the features of the allele pool in cows of the Holsteinized Black-and-White breed of cattle and its changes in the period of 2013-2018 at three breeding enterprises of the Sverdlovsk oblast. Determination of the allele pool of the EAB system of blood groups was carried out using hemolytic tests; the animals were certified by blood groups and origin (n=1812). The frequency of occurrence of each allele inherited from the paternal, maternal and allele pool as a whole was calculated. It was revealed that the G2Y2E'1Q' and I2 alleles are markers of the Holsteinized Black-and-White breed. These alleles have the highest frequency of occurrence on the part of both the father and the mother; the frequency of occurrence exceeded 10% and in some cases reached 45%. The number of alleles from the father's side was 19-21 per population of the breeding enterprise, and from the mother's side –20-22. The spectrum of non-informative alleles varies from 3 to 13 alleles per population.
УТОЧНЕНИЕ РЕФЕРЕНСНЫХ ИНТЕРВАЛОВ ПОКАЗАТЕЛЕЙ БИОХИМИЧЕСКОГО СОСТАВА КРОВИ У КОРОВ С УЧЁТОМ СТАДИЙ РЕПРОДУКТИВНО-ЛАКТАЦИОННОГО ЦИКЛА
Authors: Василевский Н.В.
Published: December 2024

Необходимость уточнения референсных интервалов биохимических показателей крови связана с тем, что качественная оценка текущего физиологического статуса животного невозможна без учёта широкого спектра биохимического и клеточного состава крови. В то же время однозначная интерпретация полученных результатов исследования крови для оценки физиологического состояния лактирующих коров не всегда однозначна и зачастую ограничиваются констатацией факта невыхода этих показателей за пределы нормы. Описанные в литературе референсные диапазоны определяются на клинически здоровых животных в пределах 95%-ного доверительного интервала, при этом обычно не учитывается возможный сдвиг значений показателей к границам «нормы» у животных с субклиническими бессимптомными расстройствами, что крайне важно для ранней диагностики нарушений. Для повышения качества физиологического мониторинга в технологических группах за счёт комплексной оценки всего спектра измеряемых показателей ранее был предложен вариант использования квалиметрического анализа. Полученные результаты показали, что на распределение границ референсных интервалов биохимических показателей крови у коров оказывают фазы репродуктивно-лактационного цикла.

The need to clarify the reference intervals of biochemical blood parameters is due to the fact that a qualitative assessment of the current physiological status of an animal is impossible without taking into account a wide range of biochemical and cellular blood composition. At the same time, an unambiguous interpretation of the results of a blood test to assess the physiological state of lactating cows is not always unambiguous and is often limited to stating the fact that these indicators do not go beyond the norm. The reference ranges described in the literature are determined on clinically healthy animals within a 95% confidence interval, while a possible shift in the values of indicators to the boundaries of the “normal” in animals with subclinical asymptomatic disorders is usually not taken into account, which is extremely important for early diagnosis of disorders. To improve the quality of physiological monitoring in technological groups through a comprehensive assessment of the entire range of measured indicators, a variant of using qualimetric analysis was previously proposed. The obtained results showed that the distribution of the boundaries of the reference intervals of biochemical blood parameters in cows is influenced by the phases of the reproductive-lactation cycle.
ПРИЕМЫОПТИМИЗАЦИИУСЛОВИЙВЫРАЩИВАНИЯОЗИМОЙТВЕРДОЙПШЕНИЦЫВОРОШАЕМОЙЗОНЕДАГЕСТАНА
Authors: Магомедов Н.Р. , Магомедов Н.Н. , Абдуллаев Ж.Н. , Абдуллаев А.А.
Published: December 2024

Представлены результаты исследований по изучению влияния различных доз минеральных удобрений и систем обработки почвы на урожайность и качество зерна нового сорта озимой твердой пшеницы Крупинка. Опыт заложен в опытной станции им. Кирова ФГБНУ ФАНЦ РД на луговокаштановой тяжелосуглинистой почве равнинной зоны Дагестана в условиях орошения. В результате проведенных исследований установлено, что максимальная урожайность озимой твердой пшеницы 5,58 т/га, в среднем за 20142019 гг., достигнута в варианте внесения повышенной дозы минеральных удобрений (N180P100) на фоне полупаровой системы обработки почвы, что на 55,1 больше, чем на контроле (без удобрений). Применение системы обработки почвы по типу поливного полупара приводило к снижению урожайности в варианте внесения повышенной дозы минеральных удобрений (N180P100) по сравнению с полупаровой системой на 0,49 т/га, или на 8,8 .

The results of studies on the effect of different doses of mineral fertilizers and tillage systems on the yield and quality of grain of a new variety of winter durum wheat Grain are presented. The experience lies in the experimental station. Kirov RUSSIAN FANZ R on meadowchestnut loamy soil of the lowland areas of Dagestan in the context of irrigation. As a result of the studies, it was found that the maximum yield of winter hard wheat 5.58 t/ha, on average for 20142019, was achieved in the variant of introduction of an increased dose of mineral fertilizers (N180P100) against the background of a semisoil treatment system, which is 55.1 more than under control ( without fertilizers). The application of the system of tillage in type of irrigation polupar led to lower yields in option of introducing high doses of mineral fertilizers (N180P100) compared with the semisteam system is 0.49 t/ha, or 8.8 .
Rapid Access to Small Molecule Conformational Ensembles in Organic Solvents Enabled by Graph Neural Network Based Implicit Solvent Model
Authors: Katzberger Paul , Hauswirth Lea M. , Kuhn Antonia S. , Landrum Gregory A. , Riniker Sereina
Published: December 2024

Understanding and manipulating the conformational behavior of a molecule in different solvent environments is of great interest in the fields of drug discovery and organic synthesis. Molecular dynamics (MD) simulations with solvent molecules explicitly present are the gold standard to compute such conformational ensembles (within the accuracy of the underlying force field), complementing experimental findings and supporting their interpretation. However, conventional methods often face challenges related to computational cost (explicit solvent) or accuracy (implicit solvent). Here, we showcase how our graph neural network (GNN)-based implicit solvent (GNNIS) approach can be used to rapidly compute small molecule conformational ensembles in 39 common organic solvents with high accuracy compared to explicit-solvent simulations. We validate this approach using nuclear magnetic resonance (NMR) measurements, thus identifying the conformers contributing most to the experimental observable. The method allows the time required to accurately predict conformational ensembles to be reduced from days to minutes while achieving results within one kBT of the experimental values.
Evaluating the functional importance of conformer-dependent atomic partial charge assignment
Authors: Osato Meghan , Baumann Hannah , Huang Jennifer , Alibay Irfan , Mobley David
Published: December 2024

Physics-based methods such as protein-ligand binding free energy calculations have been increasingly adopted in early-stage drug discovery to prioritize promising compounds for synthesis. However, the accuracy of these methods is highly dependent on details of the calculation and choices made while preparing the ligands and protein ahead of running calculations. During ligand preparation, researchers typically assign partial atomic charges to each ligand atom using a specific ligand conformation for charge assignment, often the input conformer. While it is a well known problem that partial charge assignment is dependent on conformation, little investigation has explored the downstream effects of varied partial charge assignment on free energy estimates. Preliminary benchmarks from Open Free Energy Project show that generating partial charges from different input conformers leads to variation of up to ±5.3 kcal/mol in calculated relative binding free energies due to variation in partial charges alone. In this study, we more systematically explore this issue, investigating systems where differences in partial charge generation (such as those caused by input conformer choice, partial charge engine, and hardware) may lead to differences in calculated absolute hydration free energy (AHFE) values. We demonstrate that supplying different input conformers to a partial charge engine can result in atomic partial charge discrepancies of up to 0.681 e, resulting in differences in calculated AHFE of 6.9 ± 0.1 kcal/mol. We find that even relatively small variations in partial charge assignment can result in notable differences in calculated AHFE, and thus care should be taken when assigning partial charges to ensure reproducibility and accuracy of any resulting free energy calculations.
ТРЕНІНГ ЯК ЕФЕКТИВНА ТЕХНОЛОГІЯ У ПРОФЕСІЙНІЙ ПІДГОТОВЦІ МАЙБУТНІХ АКТОРІВ: ТЕОРЕТИКО-МЕТОДИЧНІ АСПЕКТИ
Authors: Ванюга Л. С. , Калаур С. М. , Топорівська Я. В.
Published: December 2024

У статті обґрунтовано актуальність проблеми якісної підготовки майбутніх акторів засобами тренінгу. Тренінг визначено як ефективну інноваційну технологію у професійній підготовці студентів спеціальності 026 «Сценічне мистецтво». Мета наукової роботи полягає у розкритті теоретико-методичних аспектів використання тренінгу як ефективної технології у професійній підготовці майбутніх акторів. З’ясовано, що термін «професійна підготовка» розглядається науковцями як система педагогічних і організаційних заходів, які забезпечують формування в особистості сукупності знань, умінь, навичок, професійної готовності та спрямованості до діяльності. Акторську майстерність визначено як один із найважливіших компонентів професійної компетентності майбутніх акторів. Окреслено переваги використання в освітньому процесі інноваційних, мистецько-педагогічних технологій. Висвітлено сутність поняття «тренінг», яке розглядається як своєрідне поєднання інтерактивних методів, націлених на вдосконалення й розвиток умінь і навичок міжособистісного спілкування, комунікативної компетентності. Визначено мету тренінгових технологій, акторського тренінгу. Наголошено на необхідності використання в освітньому процесі вправ на розвиток уваги, уяви, імпровізації, фантазії. Розглянуто методичні особливості використання тренінгу в професійній підготовці майбутніх акторів. Охарактеризовано психофізичний тренінг і запропоновано методичні рекомендації щодо його проведення. Розкрито переваги фізичного тренінгу для професійної підготовки майбутніх акторів. Запропоновано визначення поняття «ігровий тренінг». Визначено педагогічні умови формування професійних навичок у майбутніх акторів засобами тренінгових технологій. Наведено трактування терміна «готовність до професійної діяльності». Охарактеризовано компоненти готовності майбутніх акторів до професійної діяльності: мотиваційний, когнітивний, діяльнісно-ігровий, особистісно-професійний. Результати досліджень свідчать, що тренінг є важливою технологією для підготовки високопрофесійних акторів.
Stress Estimation Based on Stochastic Method for Strength Evaluation of Floating Wind Turbines
Authors: Kim Byungmo , Kim Beomil
Published: December 2024

Structural integrity assessment of floating wind turbine (FOWT) systems is performed based on fully coupled load analysis in time domain and structural analysis that consider the complex interactions among wind, wave, and currents. However, there is a limit to repeating load and structural analyses several times for numerous DLCs required in actual projects. In this study, to determine the reasonable analysis time for structural integrity evaluation, actual time series for 1 hour and 3 hours were calculated based on FOWT load and structural analysis. Next, each time series was stochastically fitted to Weibull distribution function. The most probable maximum (MPM) von-Mises stresses were estimated according to the probability level corresponding to the design life of the platform on the fitted curves. The maximum von-Mises stress from 1 h and 3 h showed a large deviation depending on the analysis time, while the MPM von-Mises stress estimated by applying the same probability level did not show a large deviation, and the variability according to random execution also showed a similar trend. Through further research, it is expected that the optimal analysis time for estimating MPM stress can be determined, allowing for efficient structural integrity assessment for FOWT.
Safety evaluation of the food enzyme endo‐1,4‐β‐xylanase from the non‐genetically modified Trichoderma citrinoviride strain HBI‐TX01
Authors:   EFSA Panel on Food Enzymes (FEZ), Zorn Holger , Barat Baviera José Manuel , Bolognesi Claudia , Catania Francesco , Gadermaier Gabriele , Greiner Ralf , Mayo Baltasar , Mortensen Alicja , Roos Yrjö Henrik , Solano Marize L. M. , Sramkova Monika , Van Loveren Henk , Vernis Laurence , Liu Yi , Criado Ana , Apergi Kyriaki , Andryszkiewicz Magdalena , Cavanna Daniele , Marini Eleonora
Published: December 2024

Abstract
The food enzyme endo‐1,4‐β‐xylanase (4‐β‐d‐xylan xylanohydrolase; EC 3.2.1.8) is produced with Trichoderma citrinoviride strain HBI‐TX01 by HBI Enzymes Inc. The food enzyme is free from viable cells of the production organism. It is intended to be used in four food manufacturing processes. Since residual amounts of food enzyme–total organic solids (TOS) are removed in two food manufacturing processes, dietary exposure was calculated only for the remaining two processes. It was estimated to be up to 1.488 mg TOS/kg body weight (bw) per day in European populations. Genotoxicity tests did not indicate a safety concern. The systemic toxicity was assessed by means of a repeated dose 90‐day oral toxicity study in rats. The Panel identified a no observed adverse effect level of 1101 mg TOS/kg bw, the highest dose tested, which when compared with the estimated dietary exposure, resulted in a margin of exposure of at least 740. A search for homology of the amino acid sequence of the food enzyme to known allergens was made and no match was found. Known sources of food allergens were used in the manufacturing process. The Panel considered that the risk of allergic reactions upon dietary exposure to this food enzyme cannot be excluded, but the likelihood is low. Based on the data provided, the Panel concluded that this food enzyme does not give rise to safety concerns, under the intended conditions of use.
Using “Book Creator” Application in Making e-Modules as Teaching Material for English TOEFL Courses
Authors: Fitria Tira Nur
Published: December 2024

This study simulates the use of Book Creator application in making and designing e-module of the material TOEFL courses. This research is descriptive qualitative research. The result analysis shows that e-module can be created in Book Creator. We can open Chrome browser then type book creator.com on the search page. If the book creator has opened, click Create Free Account. We click “New Book”. The e-book size display will appear. The first page (cover) of e-book will be opened. On the right side of the cover there is a “+”, “i” icon and a triangular-shaped play icon. Next select the “+” icon and click “shapes” to create a second color background on the e-book page. We can select the “+” icon to add content to the page. We can select "media" then "import". We will take the contents of the files contained in the device then select the file. The selected file will appear on the e-book page. To add other content such as text, images or audio, select the “+” icon and the menu list below it. To see the appearance and content of the e-book that we created, we can click the play sign in the upper right corner. To share the e-book link, click the play sign, then click the share button on the menu bar and then specify how we want to share the e-book. Book Creator is a book creation application to make an attractive type of book. Book Creator is a simple tool for creating multimedia digital books in any academic area, from elementary school to college. Create content by combining text, music, video, drawings, photographs, and appsmash, a book will be read in different languages, including word highlighting and page flipping. Publish implies to make a book available for online viewing, download as an ePub file, or print as a PDF. Book Creator can bring creativity to our classroom, assist hesitant writers engage, and enable students to show their learning through books created by teachers and students all across the globe.
Implementation of Project-Based Learning Method to Enhance English Listening Skills of Computer Science Students at ITB AAS Indonesia
Authors: Muliasari Dewi , Efendi Tino Feri
Published: December 2024

This study aims to evaluate the effectiveness of implementing a project-based learning method in enhancing English listening skills among second-semester Computer Science students at AAS Institute of Business Technology, Indonesia. This method was chosen for its active learning approach that can increase student engagement and language proficiency development. The research employs a quantitative approach with a pre-test post-test control group experimental design. The research sample consists of two groups: an experimental group receiving project-based learning and a control group receiving conventional instruction. Data collection includes English listening tests administered before and after the learning intervention. The findings are expected to provide insights into the effectiveness of project-based learning methods in the context of English language education within the technology education setting in Indonesia.
Decision Support System for Determining the Right Fertilizer for Coffee Plants Using the AHP Method
Authors: Yusnanto Tri , Fatkhurrochman Fatkhurrochman , Muin Muhammad Abdul
Published: December 2024

Coffee is one of the leading commodities in the plantation subsector in Indonesia. Padangan Hamlet is a hamlet located in Kandangan District, Temanggung Regency, with the majority of the community as coffee farmers. However, over time, coffee productivity has decreased and a strategy is needed to increase coffee productivity. To improve the quality of good coffee, special knowledge is needed regarding fertilization of coffee plants. Determining the right fertilizer for coffee farmers is an important problem because it can affect the crop yield. In providing solutions related to this problem, this study developed a decision support system for determining the right fertilizer for coffee plants using the AHP method. The system was developed using the waterfall process model with PHP and MySQL programming languages based on the Codeigniter framework. The system was tested for functionality and validity. In addition, the system was also evaluated and a feasibility study was carried out on the system against 8 respondents consisting of members of the farmer group. The results showed that the percentage value was 81.852% which indicated that the system was categorized as very feasible.
Expert System For Diagnosing Goat Diseases Using The Forward Chaining Method (case study of SHQ Nura Farm)
Authors: Saputra Aditya Aji , Efendi Tino Feri , Pakarti Moch Bagoes
Published: December 2024

Goats are livestock that provide many benefits for human life, such as meat and milk. Healthy goats will produce quality meat and milk. good so it increases the selling price. Disease can interfere with the growth of goats and if left untreated can kill goats. Most of the farmers still have low knowledge about disease control, whereas goat livestock diseases thrive in tropical climates such as Indonesia. The number of experts available in rural areas is still limited. Information technology such as expert systems can help farmers carry out early treatment of diseases that attack goat livestock. An expert system is a system that tries to adopt human knowledge to a computer, so that the computer can solve a problem as experts usually do. The research here uses the forward chaining method to solve problems that exist in goat livestock. Forward Chaining is a reasoning inference method that uses facts to reach conclusions. The results obtained are in the form of a simple website application to help determine goat diseases and are easy to operate by entering symptom facts of 2 - 3 visible symptoms. The results of the system testing showed 80% accuracy in diagnosing diseases in goats.
Web Based He Live Doc Application System Design Analysis
Authors: Muqorobin Muqorobin , Indriastiningsih Erna
Published: December 2024

This research focuses on the design and development of the He Live Doc application, a web-based document management platform that supports real-time collaboration. Using a prototyping method with a user-centered design approach, this research aims to create a solution that increases productivity and efficiency in document management. The research methodology involves user needs analysis, system design, prototype development, and user evaluation. Results show a 30% increase in efficiency compared to traditional methods, with user satisfaction levels reaching 85%. The app offers a responsive interface, secure authentication system, real-time collaboration features, version control, and cloud storage integration. The main challenge identified was performance optimization for simultaneous editing by multiple users. This research contributes to the development of document collaboration technology and opens opportunities for further research in performance optimization and integration of artificial intelligence
Artificial Intelligence System Integrated With Smartphone Application For Early Detection Of Stunting Based On Toddler Growth Index
Authors: Iskandar Dwi , Putri Frestiany Regina , Kusuma Junianto Chandra , Saputro Rizal Tommy
Published: December 2024

Toddlers have certain characteristics and needs that require growth monitoring. Toddlers will experience a period called the "Golden age" which is a period of experiencing a golden period in early life. What needs to be considered during the Golden Age of Toddlers is the record of weight, height, and head circumference of the child at each visit, then the results are recorded using the Healthy Menu Card. Collaboration between Artificial Intelligence and IoT can provide innovative and effective solutions, these two fields of science can be collaborated with IoT Sensors for measuring weight and height, data collection and storage, AI systems for data analysis, providing recommendations, notification systems and monitoring. The method used to complete this research is a literature study and data collection to find reference materials, design technology concepts, development preparation, hardware assembly, Arduino IDE coding, uploading coding to hardware, PHP (Hypertext Preprocessor) coding, uploading PHP (Hypertext Preprocessor) Code to hosting, coding .Apk (Android Package), technology trials. This application is available on two platforms, namely web-based and Android. Everyone can weigh, but to record data to the system, users must register to get an account and QR code. QR code is used to transfer weight and height data into the system, and the account allows the user to view all weighing data and history. The system also displays a graph containing height, weight, and upper and lower limits of ideal weight.
Development of E-Learning Web for ITB AAS Indonesia Using CodeIgniter Framework
Authors: Muqorobin Muqorobin , Sumadi Sumadi , Fitria Tira Nur
Published: December 2024

With the rapid advancement of information technology, the need for effective educational platforms has become pressing. ITB AAS Indonesia has taken steps to meet this need by developing an e-learning system using the CodeIgniter framework. This paper discusses the development process of the e-learning platform designed to provide an enhanced learning experience for students and faculty. By adopting a user-centered approach and applying structured development methods, this system offers advanced features that support remote learning, user interaction, and educational content management. Evaluation results indicate that this platform enhances accessibility and efficiency in the teaching and learning process, significantly contributing to modern education in Indonesia.
Implementation of Inventory Checking System Using Finite State Machine in Role Playing Game
Authors: Kusuma Ahmad Fauzi Anggi Ariesta , Handayani Riska Dwi
Published: December 2024

This study aims to implement an inventory checking system combined with Finite State Machine (FSM) in the Role Playing Game (RPG) game genre using Arnold Hendrick's Game Development Life Cycle (GDLC) development method. In RPG games, inventory management is a crucial aspect that affects the gameplay, especially in the management of quests and item crafting features. The FSM approach is used to manage state and state transitions in randomly completed quests, providing more flexible dynamics in the completion of in-game tasks. The GDLC method was chosen to ensure that system development is carried out in a structured manner, starting from planning, design, implementation, to testing. This research integrates FSM in  the RPG Maker MV game engine, which allows developers to dynamically set various quest variables and optimize the item crafting process. By implementing FSM, items can be combined based on predefined state conditions, creating a more complex and interactive gameplay experience. The results of this study show that the application of FSM in the inventory checking system has a significant impact on flexibility in quest management and crafting. Quest variables that can be completed freely according to the player's choice, Overall, Finite State Machine can provide interactivity and depth of gameplay in RPGs with various quests that are tiered with each level, especially in the use of RPG Maker MV as an engine to apply various supporting variables to create flexibility in completing missions.
POSITIONING JASHPUR ON THE ECOTOURISM MAP: OPPORTUNITIES AND CHALLENGES IN CHHATTISGARH
Authors: Xaxa Augustin , Tiwari Anju
Published: December 2024

Ecotourism has become a pivotal tool for sustainable development, balancing conservation with community development. Jashpur District in Chhattisgarh, with its rich natural resources, diverse ecosystems, and vibrant tribal culture, holds immense potential as an ecotourism destination. However, it remains largely untapped. This paper explores how Jashpur can be positioned as a leading ecotourism destination through a comprehensive analysis of its natural and cultural assets, existing challenges, and sustainable strategies for tourism development. The study examines the critical role of community participation, government policies, and private sector engagement in developing Jashpur into a model ecotourism destination that ensures environmental preservation, socio-economic growth, and cultural heritage conservation.
INVESTOR PERCEPTION OF MUTUAL FUNDS: A STUDY ON SYSTEMATIC INVESTMENT PLAN WITH SPECIAL REFERENCE TO MOTIHARI, BIHAR
Authors: Singh Shivendra , Yadav Nidhi , Kumari Priya
Published: December 2024

The mutual fund emerged as a medium to mobilize the savings of the common public towards productive use. A mutual fund is a trust that mobilises the savings of several small investors who have a common financial goal. This paper aims to investigate valuable insights into how SIPs and mutual funds are perceived in developing regions like Motihari Bihar. The data from 250 respondents were collected using a structured questionnaire through a convenient sampling method and gathered data were analysed through SPSS 23 using statistical tools such as Chi-square test, ANOVA, and Correlation Test. The majority of investors in Motihari City are aged 31-40, with 86% being male. The largest group is undergraduates, with 58.8% being private employees. Most investors have a monthly income between 50000-100000. This study explores Motihari region mutual fund investors' attitudes and perspectives, focusing on satisfaction levels, investing preferences, and demographics. Despite concerns about the disclosure of information and challenges during the investing process, most investors are confident in mutual fund's ability to provide returns and maintain well-diversified portfolios.
Sahâbe İhticâcına Arz Prensibinin e Silentio Deliliyle Benzerlik Sorunu: Aralarındaki İlişki ve Karşıtlıklara Dair Bir İnceleme
Authors: Yüksel Furkan
Published: December 2024

İslâm ilim geleneğinde Hz. Peygamber’e ait olanla olmayan bilginin sahih bir şekilde tespit edilmesi büyük önem arz etmektedir. Bu bağlamda haberlerin doğruluğunu ve güvenilirliğini belirlemek için çeşitli metodolojiler geliştirilmiştir. Hanefî fukahâsı, bu metodolojiler arasında kendine özgü bir yaklaşım benimsemiş ve haber-i vâhidlerin kabul edilebilirliğini dört temel ölçüt üzerinden değerlendirmiştir. Bu dört asıldan birisi de sahâbe ihticâcına arz prensibidir. Hanefî usulcüler, sahâbe arasında bir konuda ihtilaf çıktığında o konuyla alakalı rivâyetin ihtilaf anında delil olarak sunulmamasını o haberin makbul olmadığının alameti olarak değerlendirmişlerdir. Hanefîlerin benimsemiş olduğu bu prensip oryantalistlerin e silentio/sessizlik delilini çağrıştırttığı ifade edilmektedir. e Silentio delili “Bir hadisin belirli bir zaman diliminde bulunmadığını ispatlamanın en iyi yolu, eğer hadis gerçekten o dönemde mevcut olsaydı, o dönemdeki fıkhî tartışmalarda delil olarak kullanılması gerektiği halde kullanılmadığını ortaya koymaktır” şeklinde açıklanmıştır. Bu sebeple Hanefî usûlcülerin bu haber-i vâhid tenkit kriterinden neyi kastettiklerinin, bunun nasıl anlaşılması ve uygulandığının doğru bir şekilde tespit edilmesi gerekmektedir. Çalışmanın en önemli amacı ise bu
prensibin e silentio deliliyle ilişkisi ve karşıtlıklarının ortaya çıkarılmasıdır. Bu sebeple araştırmada hem literatür taraması hem de mukayeseli bir yöntem takip edilmiştir. Hanefî usûl eserleri ve e silentio delilini daha çok kullanan Schacht (1902-1969) ve Juynboll’un (1935-2010) eserleri çalışmanın ana kaynaklarını oluşturmaktadır. Cessâs'tan (ö. 370/981) itibaren bu asla atıfta bulunan Hanefî usûlcülerin bakış açıları incelendiğinde, her iki delilin görünüşte benzer yaklaşımlar sergilediği düşünülse de ayrıntılarda farklı amaçlara sahip oldukları sonucuna ulaşılmıştır.
Arte e design na formação continuada de docentes da educação profissional: relato de experiência.
Authors: Ghizi Marcelo , Martins Bianca
Published: December 2024

O objeto deste artigo é o processo de concepção e aplicação um curso de arte e design que feza parte de um programa de formação continuada de professores. A partir da apresentação de conceitos e fundamentos arte e design, o pensamento projetual é apresentado como ferramenta para o desenvolvimento de habilidades consideradas fundamentais tanto para professores quanto para estudantes que atuam na resolução de problemas reais da indústria. O artigo está organizado em três partes: na primeira, de modo breve, apresenta-se o contexto e as ideias centrais que estimularam a concepção do curso; na segunda, a partir dos resultados de aplicação, destacamos importância da consciência projetual na atuação dos docentes e, por fim, apresentamos algumas reflexões sobre a utilização da Aprendizagem Baseada em Design na formação continuada de docentes que atuam na educação profissional. Palavras Chave: design; consciência projetual; educação profissional
Análise dos aspectos do design emocional na rede social Tiktok e seu impacto no comportamento dos usuários.
Authors: Barros Ana Tereza Rio do Rego , Brito Marina de Burgos , Castelão Júlia Pinheiro , Coelho Maria Luíza Pedrosa Florentino de Paiva , Lima Luana Vieira Alves de , Larrazábal Rodrigo Rios de
Published: December 2024

Este estudo examina como os princípios do design emocional são aplicados na plataforma TikTok e seu impacto no comportamento dos usuários. Baseado nas teorias de Donald Norman, Pieter Desmet e Anna Pohlmeyer, a pesquisa explora três níveis de design emocional: visceral, comportamental e reflexivo. Utilizando uma metodologia exploratória que inclui revisão de
literatura, análise de design, questionários e observações de uso, o estudo revela que elementos visuais atraentes, interações intuitivas e personalização do conteúdo são cruciais para manter os usuários engajados. Os resultados mostram que 90% dos participantes utilizam o TikTok diariamente, destacando a eficácia das estratégias de design emocional. No entanto, também foram identificados impactos negativos, como distração e procrastinação, enfatizando a necessidade de um uso equilibrado da plataforma. Este estudo fornece insights valiosos para o desenvolvimento de experiências digitais mais saudáveis e envolventes. Palavras-Chave: design emocional; tiktok; mídias sociais.
Artistas e redes sociais: um levantamento da experiência do usuário sob a ótica do design.
Authors: Kawagoe Carolina Arissa , Ono Isabella Mari , Dick Maurício Elias Klafke
Published: December 2024

As redes sociais são ambientes propícios à criação de laços e círculos online, mas que também podem causar emoções negativas. Especificamente para a comunidade artística, é possível perceber uma competição de visibilidade de conteúdos e uma predominância redes sociais com objetivos majoritariamente relacionadas à carreira profissional. Diante disso, em uma abordagem de design centrada no usuário, este estudo teve por objetivo encontrar contribuições que auxiliem no design de redes sociais direcionadas a artistas, a partir da compreensão da experiência do usuário com este tipo de interface. Para isso, realizou-se um levantamento de campo que permitiu identificar as redes sociais mais utilizadas pelos artistas, assim como seus objetivos, necessidades, carências, preocupações e emoções no uso destas; além dos aspectos que formam seu senso como comunidade. Ao fim, concluiu-se que os artistas demandam por ambientes que sejam mais empáticos e inclusivos e que incentivem a colaboração e a troca de experiências. Palavras-Chave: Design centrado no usuário; redes sociais; artistas.
Avaliação de usabilidade de um sistema de gestão acadêmica.
Authors: Razza Bruno , Kattel Cristina do Carmo Lucio Berrehil el
Published: December 2024

Sistemas de gestão acadêmica são essenciais em universidades e devem ser desenvolvidos considerando a usabilidade para diferentes perfis de usuários e necessidades locais. A revisão da literatura revelou que a maioria dos estudos sobre sistemas de gestão acadêmica utilizou questionários padronizados ou personalizados focados na percepção de usabilidade, com poucos estudos empregando métodos experimentais. Este estudo avaliou objetiva e subjetivamente o sistema de gestão acadêmica da Universidade Estadual de Maringá, utilizado por alunos de graduação. A metodologia incluiu uma avaliação heurística com especialistas, além de avaliações subjetivas por meio de questionários e análises de tarefas. Os resultados indicaram sérios problemas relacionados à organização e disponibilidade informações, layout e fluidez das tarefas. A usabilidade percebida foi considerada de moderada a ruim nas avaliações objetivas e subjetivas e conclui-se que métodos experimentais foram mais úteis para gerar parâmetros de projeto. Palavras Chave: Usabilidade; experiência do usuário; sistema de gestão acadêmica.