bluuebunny/crossref_metadata_2025 huggingface dataset:
«No matarás ni con hambre ni con balas». Las mujeres de los comedores populares autogestionarios en El Agustino durante la violencia política
Authors: Minaya Rodríguez Jacqueline
Published: April 2023

Los comedores populares autogestionarios - CPA tienen más de 35años de existencia, desde 1978, a la cabeza de mujeres valerosas, en una Lima pobre, migrante y luchadora. Estas mujeres lucharon frente al Estado por derechos y reivindicaciones, como servicios básicos y políticas alimentarias. Las mujeres hicieron, de temas caseros, políticas públicas que lograron sostener, en gran medida, la crisis económica a fines de la década de 1980 e inicios de la de 1990, dando así muestras de organización a gran escala en un con- texto sumamente difícil. En ese complicado panorama, convivieron con integrantes del grupo subversivo del Partido Comunista del Perú-Sendero Luminoso - PCP-SL, que incursionó en las barriadas para «profundizar las contradicciones» y aplicó, en nombre de la justicia, estrategias de guerra.La investigación rastrea las trayectorias de las exdirigentas de los CPA en el distrito limeño de El Agustino, y recoge sus testimonios sobre la violencia política que les tocó vivir entre 1978 y 19922 ysobre las problemáticas relaciones con el Estado. Esta convivencia produjo un complicado tejido de hilos muy delgados, donde lascercanías y lejanías de estas mujeres frente a Sendero Luminoso fueron parte de un proceso más complejo.
La acción política frente al estigma de la violencia entre los jóvenes universitarios posconflicto: los casos de la Universidad Nacional Mayor de San Marcos y la Universidad Nacional de San Cristóbal de Huamanga
Authors: Jave Iris , Cépeda Mario , Uchuypoma Diego
Published: April 2023

Este artículo explora los mecanismos por los cuales el período de violencia en el país sigue impactando las universidades, esta vez mediante la violencia simbólica expresada en formas de estigmatización desde un actor interno (la familia) y desde un actor externo (los medios de comunicación). En ese contexto, los jóvenes de esta generación construyen nuevas formas de participación política; la universidad como espacio de deliberación y de acción política uni- versitaria se ve mediada por el temor a ser señalado y estigmatizado como una consecuencia casi natural de la violencia, sin descuidar el desinterés por la política que prevalece en las últimas décadas. Pese a ello, encontramos que los jóvenes han llevado su experiencia participativa hacia nuevas formas de acción que, sin proponérselo o reconocerlo, son también plataformas políticas. Concluimos que entre el estigma —la supuesta presencia del Movadef— y la falta de canales institucionales, los universitarios se encuentran en una etapa no cohesionada pero que podría configurarse como acción colectiva.
Relation of Known Hallmarks of Aging to the Ontogenesis Program
Authors: Salnikov Lev
Published: April 2023

A brief assessment of the current state of the use of Hallmarks of aging is given in the article. It is noted that the biological clock based on registration of DNA methylation process is only a statistical indicator and has no direct connection to the known mechanisms of aging, reflecting only the fact of genome regulation during ontogenesis. In other words, the process of genome methylation is not the leading program, but rather it fixes the result of the main program of ontogenesis. The same problems are inherent to aging markers based on registration of changes in RNA synthesis levels in different genes. In our opinion, the Hallmarks of aging should primarily be connected with or directly reflect the most fundamental bases and processes which are universal for any organisms.
Comparative analysis of water and carbon dioxide injection for the thermohydraulics of an EGS project in Dikili Geothermal Field, Türkiye
Authors: BENİM Ali Cemal , ÇİÇEK Aydın
Published: April 2023

A comparative numerical analysis of the thermohydraulics of an enhanced geothermal system (EGS) project in Türkiye in Dikili area is presented. The fractured granodiorite is modelled as porous media, utilizing the numerically suggested data of other authors for the corresponding hydraulic characteristics. As the heat transmission fluid, two different mediums are alternatively considered. These are the more classical medium, water and the supercritical Carbon Dioxide (sCO2). Transient calculations are performed for a time period of twenty years, comparing the temporally developing results obtained for water and sCO2 with each other. Based on modeling parameters and assumptions, higher production temperatures are observed with sCO2, in comparison to water, implying an advantage for sCO2 usage as a working fluid in EGS. This is accompanied by the further advantage of a lower pressure drop for sCO2. On the other hand, the temperature advantage is relativized by the lower specific heat capacity of sCO2 causing a decrease in the production thermal power. In general, the present re found to be encouraging for a further and more detailed analysis of the employment of sCO2 as working fluid in EGS.
Experimentos virtuales en tópicos de ingeniería eléctrica.
Authors:   UJAT, Vázquez León Rubén , RodríguezLozoya Javier
Published: April 2023

En las áreas de ingeniería, las prácticas de laboratorio son una herramienta didáctica fundamental para propiciar un aprendizaje significativo de los futuros profesionistas. Actualmente, estas prácticas desarrolladas en laboratorios convencionales, tienen la característica de que requieren espacios físicos con equipo especializado, que generalmente es muy caro, donde se realizan prácticas o experimentos que involucran costos en materiales, sustancias y uso de la energía eléctrica, con horarios sin holgura y obvio, con la presencia física de los estudiantes. Esta propuesta contiene un compendio de experimentos virtuales para adecuarse a programas educativos flexibles y enfocados a competencias, y que presente un buen complemento al aprendizaje obtenido en los laboratorios convencionales donde no se tenga la limitante de un tiempo específico para realizar el experimento, para lo cual, el estudiante lo pueda realizar desde su hogar o cualquier otro espacio no especializado.
Denotation and Connotation of Mandau, A Weapon of Kanayatn Dayak Tribe in West Kalimantan
Authors: Pranoto Iwan , Iksan Nur , Yuliati Ika
Published: April 2023

The culture and the cultural product itself that develop in today’s society cannot be separated from the recognition and agreement of some community groups, the philosophical values, or the natural signs that are embedded in everyday life, or usually called myths. One of them is Mandau, a weapon of the Kanayatn Dayak tribe, in Sebetuk village, Ngabang sub-district, Landak district, West Kalimantan. The Mandau is a weapon owned by the Kanayatn Dayak people and is often used for many purposes such as cutting the grass, chopping the wood, cutting the meat from hunted animals, protecting themselves from wild animals, conducting traditional rituals and as weapons of war. This Mandau is differentiated into two categories, the one that has sacred value and another one that does not. In this study, the object of research was the one with a scared value. The Mandau that developed in the Kanayatn Dayak community has its own a message and meaning. The denotation and connotation of the Mandau were discussed in this study based on semiotic of Roland Barthes's thought. By employing a qualitative approach, the fine art elements of the Mandau such as the decorative motifs, colors, and shapes became the main discussion. Each of them has its own meaning and thus it is trusted by the local community.
Editorial
Authors: Coutinho Luciana Cristina Salvatti
Published: April 2023

Num cenário, ainda, de adversidades, mas também de esperança dado o pleito presencial vivido nesse ano, é que a Revista Histedbr On-line publica em 2022 seu volume 22, contando com 55 artigos e 4 resenhas, abordando temáticas educacionais e perspectivas teórico-metodológicas diversificadas. A vinculação institucional das autoras e dos autores dos manuscritos publicados nesse volume é, também, diversa. Nacionalmente, contamos com colaborações de pesquisadores e pesquisadoras das seguintes instituições: Instituto Geremário Dantas, EMEIEF Prof. Affonso Basile/Angatuba/SP, Rede Municipal de Ensino de Curitiba/PR, Rede Municipal de Ensino de Rio das Ostras/RJ, Rede Municipal de Ensino de Cuiabá/MT, Rede Estadual de Ensino do Paraná, Colégio Universitário Maranata, Rede Municipal de Ariquemes/RO, Rede Estadual de Minas Gerais, Associação Gente de Bem, Escola Judicial do Estado do Paraná, Secretaria Estadual de Educação do Maranhão, Secretaria Municipal de Educação de Panambi, Rede Pública Municipal João de Miriti, Escola Técnica Estadual do Estado de São Paulo, Centro Solidário de Educação Infantil de Uberlândia, Rede Municipal de Toledo, UFLA, Unicentro, UNIOESTE, UNESP, UFPR, UFOPA, UFMS, UNINOVE, UFPA, UFTM, PUC-PR, PUC-Goiás, UFT, UFF, UFRGS, UENP, UFAL, UFRRJ, UERJ, UFRGS, UNIR, Unicamp, IFMS, UFMG, UNIB, IF Baiano, IFBA, IF Sudeste MG, UniAnchieta, UFSCar, UESB, IFG, UFC, UEPG, PUC-SP, UFU, UNIFAP, UTFPR, IFPR, IFCE, IFSP, USP, UnB, Secretaria de Estado de Educação do Distrito Federal, UNESPAR, FURG, UEM, UFMT, IFMT, UFPB, UNIPAR, UFMA. Contamos, ainda, com a contribuição de autoras vinculadas a instituições internacionais, tais como: Universidad Nacional de Rosario (Argentina), Universidad de Oriente (Venezuela), Facultad Latinoamericana de Ciencias Sociales/FLACSO (Argentina), Universidad de Buenos Aires (Argentina). A diversidade temática, de abordagens e institucional é atravessada, contudo, por uma marca comum: a defesa intransigente por uma Educação efetivamente pública, laica, gratuita e de qualidade social para todas as pessoas, indistintamente.
Oyunlaştırma, Tüketici Katılımı, Marka Sadakati ve Uygulama Kullanmaya Devam Etme Niyeti Arasındaki İlişkilerin Belirlenmesi
Authors: Gökmerdan Önder Leyla
Published: April 2023

Oyun kavramı, dijitalleşmenin hızlı gelişimiyle birlikte oyunlaştırma kavramına dönüşmüştür. Birçok alanda kullanımı giderek artan oyunlaştırma, işletmeler açısından tüketicileri ile bağ kurma ve ilişkilerini güçlendirmenin yeni ve çekici bir yoludur. Öte yandan tüketicilerin ilgilerini çeken mobil uygulamalar sayesinde işletmeler, tüketicilerine keyifli bir deneyim sunarak marka sadakati oluşturabilirler. Oyunlaştırma ve mobil uygulamaları birleştirerek tasarlanan oyunlaştırılmış mobil uygulamalar ile müşterilerin markaya olan ilgilerini artırmak, satın alma davranışlarını tekrarlatmak ve onları sürece dâhil ederek uygulamayı kullanmaya devam etmelerini sağlamak amaçlanmaktadır. Buradan hareketle araştırmanın temel amacı, oyunlaştırılmış mobil uygulamalar, tüketici katılımı, marka sadakati ve uygulama kullanmaya devam etme niyeti arasındaki ilişkilerin belirlenmesidir. Bu amaçla Ankara’da yaşayan 18 yaş ve üzeri, kahve zinciri markalı mobil uygulamaları kullanan tüketiciler üzerinde bir anket çalışması yürütülmüştür. Toplanan veriler kullanılarak değişkenler arasındaki ilişkileri gösteren model Smart-PLS programı kullanılarak en küçük kareler yol analizi ile test edilmiştir. Elde edilen sonuçlara göre elemantal tetrad modelinin öngördüğü oyunlaştırılmış mobil uygulamaların tasarımı için kullanılan hikâye, mekanik, teknoloji ve estetik boyutları tüketici katılımını pozitif yönde etkilemektedir. Ayrıca tüketici katılımının marka sadakatini ve kullanmaya devam etme niyetini pozitif etkilediği tespit edilmiştir.
Evaluating model teacher education and training at Vietnam's universities of technology and education
Authors: Cao Chinh Danh , Vu Hang Thi Thuy , Nguyen Tuan Van , Nguyen Hung Thanh , Nguyen Thanh Thi
Published: April 2023

The traditional educational paradigm has become outdated as a result of changes in both the cultural and socioeconomic setting. A more sustainable and acceptable teacher is needed in education. A quantitative study was conducted. 95 administrators and teachers at the University of Technology and Education participated in this study with the aim of analyzing the current status of the teacher education model at the institution. According to the findings of the study, the model for educator preparation has been put into practice primarily through the processes of planning, organizing and directing activities related to educator preparation as well as inspecting and assessing the quality of education. The outcomes of the study indicate that it is essential to design educational programs that are appropriate for the present context. In particular, the study suggests that one of the most important steps towards achieving success is to incorporate technology into teaching methods. The process of educating teachers with the right degree of expertise and skills should be emphasized by educators and policymakers by developing relationships with other educational institutions and allowing teachers to participate in internships.
Frecuencia de migraña y discapacidad generada en estudiantes de medicina humana de una universidad privada en Lima, Perú
Authors: Vilchez-Villarreal Nicole , Oyola-Feijóo Almendra , Romani-Romani Franco , Del-Carmen-Sara José Carlos
Published: April 2023

Objetivo: Estimar la frecuencia de migraña, y discapacidad generada en estudiantes de medicina de una universidad privada de Lima Metropolitana. Métodos: Estudio transversal en una muestra no probabilística por conveniencia, mediante la aplicación online del autocuestionario ALCOI-95, para evaluar la presencia de migraña, seguido por el cuestionario MIDAS para medir la discapacidad en los positivos al primer cuestionario. El rendimiento académico fue evaluado mediante el promedio ponderado de sus calificaciones. Resultados: Cuarenticinco (21,6%) de 208 estudiantes experimentaron migraña (12,5% con aura y 9,1% sin aura), 14 (33,3%) de los cuales mostraron discapacidad severa y 12 (28,6%) moderada. Los portadores de migraña con aura tuvieron una media menor del promedio ponderado acumulado de sus calificaciones, comparado con aquellos con migraña sin aura. Los factores independientemente asociados a la migraña fueron tener un miembro de la familia nuclear con migraña y problemas para mantener el sueño. Conclusión: Dos de cada 10 estudiantes presentaron migraña y 1/3 de los afectados experimentó discapacidad severa.
Trastorno de Acumulación: A propósito de un caso
Authors: Cabrejo-Mendoza Hernan J. , Albornoz-Muñoz Delia P.
Published: April 2023

El trastorno de acumulación se caracteriza por una extrema dificultad para deshacerse o descartar artículos, independientemente de su valor real, originando con ello múltiples síntomas y problemas cotidianos de todo tipo. Aunque la severidad es más marcada en adultos mayores, el cuadro es de instalación progresiva a lo largo de varias décadas. Se presenta el caso de un paciente varón de 49 años, con inicio de la enfermedad desde los 15 años, guardando libros y cuadernos usados con la idea de que podrían ser útiles en el futuro; además de manifestaciones significativas de ansiedad. La acumulación de otros objetos como herramientas, ropa y utensilios de cocina se fue intensificando junto con el incremento de la ansiedad tras varias pérdidas familiares. El paciente buscó atención médica en diferentes centros sin encontrar alivio. Finalmente, el diagnóstico, el tratamiento psicofarmacológico y psicoterapéutico fueron replanteados con resultados favorables.
Bio-fabrication of liver cancer stem cells and testing of gemcitabine
Authors: Cevik Evrim , Erdogan Omer , Cevik Ozge
Published: April 2023

Aim: Cancer stem cells are cell populations that are essential in drug resistance and cancer metastasis. Some liver cancer cells exhibit the characteristics of cancer stem cells, and it is crucial to study the activities and interactions of drugs in these cells. Huh7 is a human liver cancer cell with stem cell biomarkers and is used with induced pluripotent stem cells to form various cancer organoids through encapsulation methods. Due to their ease of use without animal testing, bio-fabrication studies of cell-encapsulated models have gained importance in the pharmaceutical industry in recent years. This study aimed to biofabricate Huh7 human liver cancer stem cells by alginate encapsulation and test gemcitabine’s efficacy. Methods: Huh7 cells were encapsulated with alginate (0.8% w/v) and fibronectin, and their viability was evaluated with 3.2 µM gemcitabine on days 1, 3, 6, 9, and 12. Furthermore, gene expressions of stem cell markers CD90 and AFP were evaluated in encapsulated Huh7 cells by qPCR. In addition, IL-6 secretion in the cell medium was measured by ELISA for the tumor microenvironment. Results: Encapsulation of Huh7 cells was found to maintain their viability and stem cell properties for up to 12 days. In addition, alginate-encapsulated Huh7 cells were bio-fabricated to demonstrate long-term gemcitabine response. While the effect of the gemcitabine was evaluated in alginate-encapsulated Huh7 cells, CD90 and AFP mRNA levels were significantly reduced in the cells and IL-6 secretion was decreased in the tumor microenvironment. Conclusion: This study demonstrated that bio-fabrication of alginate-encapsulated Huh7 cells is a novel approach for long-term drug testing in liver cancer models. Bio-fabricated alginate-encapsulated cancer stem cells may be a cheaper and faster method for the testing of many drugs.
Benefits of physical exercise on Alzheimer's disease: an epigenetic view
Authors: Li Song
Published: April 2023

Increasing lines of evidence have indicated the beneficial impacts of exercise on the neurodegeneration and cognitive decline of Alzheimer’s disease (AD). While general mechanisms underlying the positive effects, including the elevated neurotrophins level, improved neurogenesis and neuroplasticity, restored angiogenesis and autophagy, and reduced neuroinflammation, have been well documented, the epigenetic mechanisms of exercise on AD, however, are still inconclusive. Exercise can regulate the expression of those AD-related genes or proteins through various epigenetic modulations, thereafter rescuing AD pathologies and improving cognitive deficits of AD. In this review, we briefly summarized recent research advances in the beneficial impacts of exercise on cognition and AD and discussed the underlying mechanisms from an epigenetic point of view, including DNA methylation, histone modifications, and non-coding RNAs. A deep understanding of how exercise epigenetically promotes cognitive and pathological recoveries in AD is crucial for the future discovery of precise exercise procedures or exercise-like remedies to treat this disease.
The metabolism of novel flame retardants and the internal exposure and toxicity of their major metabolites in fauna - a review
Authors: Hou Rui , Sun Chuansheng , Zhang Siqi , Huang Qianyi , Liu Shan , Lin Lang , Li Hengxiang , Xu Xiangrong
Published: April 2023

The worldwide production and usage of novel flame retardants increase their exposure to non-human fauna. Animals can accumulate and metabolize these novel flame retardants including novel halogenated flame retardants (NHFRs) and organophosphate flame retardants (OPFRs), which is of considerable significance to their internal exposure and final toxicities. In this review, recent studies on the metabolic pathways and kinetics of the two classes of novel flame retardants and the internal exposure and toxicity of their major metabolites are summarized. The results showed that the metabolic pathways of OPFRs were similar among various animals, while the metabolism kinetics (or toxicokinetics) were variable among species. O-dealkylation, hydroxylation and phase II conjunction were the most likely pathways for OPFRs. NHFRs might be metabolized through the pathways of debromination, hydroxylation, dealkylation, and phase II conjunction. We also suggested that di-alkyl phosphates (DAPs) and hydroxylated OPFRs (OH-OPFRs) were the predominant metabolites in the animal body. DAPs, 2,3,4,5-tetrabromobenzoic acid (TBBA) and 2-ethylhexyl tetrabromophthalate (TBMEHP) have relatively higher internal exposure levels in fauna, which might attribute to their high conversion rate and stability in the body. The metabolism of OPFRs and NHFRs in non-human animals may eliminate their acute toxicity but not their chronic toxicities (especially for endocrine-disrupting effects), which suggests attention should also be paid to the major metabolites. Based on the issues mentioned above, we proposed that the metabolic processes in multitrophic organisms, the transfer of major metabolites across the food web, and the co-exposure of the novel flame retardants and their metabolites in fauna are worth studying in the future.
A tool to assess the mock community samples in 16S rRNA gene-based microbiota profiling studies
Authors: Shetty Sudarshan A. , Kool Jolanda , Fuentes Susana
Published: April 2023

Inclusion and investigation of technical controls in microbiome sequencing studies is important for understanding technical biases and errors. Here, we present chkMocks, a general R-based tool that allows researchers to compare the composition of mock communities that are processed along with samples to their theoretical composition. A visual comparison between experimental and theoretical community composition and their correlation is provided for researchers to assess the quality of their sample processing workflows.
Design and Implementation of an Orbitrap Mass Spectrometer Data Acquisition System for Atmospheric Molecule Identification
Authors: Wang Wei , Li Yongping
Published: April 2023

Orbitrap mass spectrometers have been widely used in environmental component analysis . This paper presents an enhanced data acquisition system for in-situ detection of Orbitrap mass spectrometry, which enables in-suit real-time signal processing and analysis for atmospheric molecules with small mass numbers.During previous space atmospheric explorations, quadrupole mass spectrometry (QMS) was usually utilized for analyzing isotopic compositions and complicated compounds in the mixture. However, the inevitable ion scattering and drift during mass transfer, as well as the QMS attenuator loss, result in a relatively lower signal-to-noise ratio of the produced mass spectrum. In recent years, a novel mass spectrometer, called an Orbitrap mass spectrometer, has been gradually accepted and used because of its non-destructive detection ability, high mass resolution, and accuracy. Nevertheless, Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS) is preferred over the Orbitrap mass spectrometry for ground applications, especially for detecting low-mass components (e.g. below 50 atomic mass units) due to the former’s superior resolution. As the mass number decreases, the detection system demands a higher sampling and processing rate. Additionally, in ground-based scenarios, mass spectrometry analysis software on computers is often employed to analyze the signals. Therefore, in order to achieve in-situ detection of the space atmospheric environment using the Orbitrap mass spectrometer, this paper proposes a real-time signal acquisition and processing system for mass spectrometry analysis. The system comprises of signal conditioning circuits, analog-to-digital conversion circuits, programmable logic circuits, and related software. These components perform spectrum analysis and process the signal in real-time on hardware components, allowing for high-speed acquisition and analysis of the signals produced by the Orbitrap mass spectrometer.
Economic Impact of the Implementation of a Multidisciplinary Diabetic Foot Clinic in a Tertiary Hospital
Authors: Pérez-Montes Alejandra , Ricou Ríos Laura , Pons Calsapeu Arnau , López Seguí Francesc , Riera Clàudia , Sirvent Marc , Reynaga Esteban , Viadé Jordi , Malagon Paloma , Soldevila Berta , Perez Ricard , Casademunt Elena , Bonet Glòria , Puig Domingo Manel , Estrada Oriol , Alonso Núria
Published: April 2023

Objective: Diabetes and Diabetic Foot represent a major global burden for patients and the healthcare system. Multidisciplinary Diabetic Foot Clinics have been shown to be an effective therapeutic model for reducing major amputations and mortality rates. The aim of this article is to assess the economic impact of the implementation of a Multidisciplinary Diabetic Foot Clinic in a tertiary hospital in Catalonia.Methods: Retrospective observational cost-benefit study of all subjects with diabetes admitted with the diagnosis of a major amputation due to Diabetic Foot from 2010 to 2020. Direct and indirect costs were compared before and after the introduction of the Multidisciplinary Diabetic Foot Clinic, considering the probability of Emergency Room visits, Diabetic Foot Clinic visits, hospitalizations and outpatient clinic consultations for patients with Diabetic Foot. Results: The individual cost per Diabetic Foot patient was €14,768 before the implementation of the unit, with over 50% of the cost attributed to hospitalization and almost 20% to the costs associated with the morbidity caused by an amputation. After the implementation of the clinic, the expected cost was reduced to €5,985 due to a 40% reduction in the probability of hospitalization, which is the main factor contributing to cost savings. Overall, the implementation of the clinic resulted in cost savings per patient valued at €8,783, of which, €7,165 are related to hospital benefits. Conclusion: The results of this analysis contributes to the evidence suggesting that Multidisciplinary Diabetic Foot Clinics are cost-effective, by demonstrating that they have a positive impact on patient health while also reducing the utilization of healthcare resources.
Systemic Health Factors Related to Rapid Oral Health Deterioration Among Older People
Authors: Van der Putten Gert-Jan , De Baat Cees
Published: April 2023

The oral health of older individuals can be negatively impacted by various systemic health factors, leading to rapid oral health deterioration. Older people are at risk of experiencing adverse reactions to medications due to multimorbidity, polypharmacy, and changes in pharmacokinetics and pharmacodynamics. Hyposalivation, a significant side effect of some medications, can be induced by both the type and number of medications used. Frailty, disability, sarcopenia, care dependency, and limited access to professional oral healthcare can also compromise the oral health of older people. To prevent rapid oral health deterioration, a comprehensive approach is required that involves effective communication between oral healthcare providers, other healthcare providers, and informal carers. Regardless of their health status, it is crucial to prioritize the well-being of older people. Oral healthcare providers have a responsibility to advocate for the importance of maintaining adequate oral health and to raise awareness of the serious consequences of weakened oral health. By doing so, we can prevent weakened oral health from becoming a geriatric syndrome.
Soil Quality Evaluation Based on A Minimum Data Set (MDS)—A Case Study of Tieling County, Northeast China
Authors: Qian Fengkui , Yu Yuanjun , Dong XiuRu , Gu Hanlong
Published: April 2023

Soil quality is related to food security and human survival and development. In recent years, due to the acceleration of urbanization and the increase of abandoned land, land degradation occurs, poor topsoil quality. In this study, the minimum data set (MDS) was constructed through principal component analysis (PCA) to determine the indicator data set for evaluating topsoil quality in Tieling County, China. In addition, the soil quality index (SQI) was calculated to analyze the spatial distribution characteristics and influencing reasons of topsoil quality in Tieling County. The re-sults showed that MDS included total potassium (TK), Clay, zinc (Zn), soil organic matter (SOM), soil water content (SWC), cation exchange capacity (CEC), pH, and copper (Cu). The MDS indicators can well replace all indicators to evaluate the topsoil quality in the study area. The overall soil quality of Tieling County showed a trend of low in the east and high in the west, and gradually increased from the hilly area to the plain area. The evaluation results are consistent with field research, which can provide reference for other topsoil quality evaluation, and it also provide a basis for the formulation of soil quality improvement measures.
Прямая и обратная задачи сейсморазведки анизотропных и диспергирующих упругих сред на основе объемных интегральных уравнений
Authors: Александров Павел Николаевич , Aleksandrov Pavel Nikolaevich , Кризский Владимир Николаевич , Krizsky Vladimir Nikolaevich
Published: April 2023

Теория сейсморазведки базируется на теории упругости, где одну из важных ролей
играют материальные уравнения -- закон Гука. В уравнения теории упругости входит плотность среды. В общем случае в каждой точке среды необходимо определить матрицу параметров размерностью 12$\times$12 элементов. Эти параметры могут
быть диспергирующими, т.е. зависеть от частоты. Для такого количества параметров решение обратной задачи с использованием стандартных процедур измерений
и вычислений является затруднительным.
Предложен новый подход к решению обратных задач, основанный на развитии идеи
М.В. Клибанова. Исходя из векторного представления уравнений теории упругости,
получен баланс упругой энергии и интегральные уравнения для исследования принципа взаимности. Выведены объeмные интегральные уравнения, на основе которых
получено решение обратной задачи теории упругости. Рассмотрены некоторые примеры численной реализации решения прямой и обратной задач теории упругости в
трехмерно-неоднородных анизотропных моделях геологической среды.
Bicompact schemes for the joint solution of a one-group system of quasi-diffusion equations with the energy equation
Authors: Karavaeva Nataliia Igorevna
Published: April 2023

High-order bicompact schemes are proposed for one of the stages of the HOLO algorithm for solving the radiative transport equation and implemented. The system of quasi-diffusion equations is solved together with the energy equation. The schemes have a fourth-order approximation in space on a two-point stencil, integration over time is carried out using the diagonal-implicit Runge–Kutta method of the third order of approximation, each stage of the method can be represented as an implicit Euler method. It is proposed to organize an iterative process to find a solution, since the coefficients of the system are non-linear functions of temperature. The schemes are used for a number of analytical tests, the convergence in time and space with the declared orders is shown.
Renal reflux in retrograde intrarenal surgery
Authors:   European Medical Centre, Moscow, Russian Federation, Grigorev N.A. , Rubanov V.A. ,   European Medical Centre, Moscow, Russian Federation
Published: April 2023

Objective: to study renal reflux and reverse suction of irrigation fluid during retrograde lithotripsy. Patients and methods. This study was conducted at the Clinic of Urology, European Medical Center between 2021 and 2022 and included 20 urolithiasis patients who underwent retrograde lithotripsy. The volume of renal reflux was assessed by precise measurement of the amount of injected and discharged irrigation fluid. In one out of 20 patients (41-year-old male with a coral stone in the left kidney), a nephrostoma was installed before hospitalization. It was used not only as an additional drainage, but also for measuring intrarenal pressure during retrograde lithotripsy. Results. The difference between the volumes of injected and discharged irrigation fluid during retrograde lithotripsy was 29.02%. Antegrade measurement during retrograde lithorpsy with an ureteral access sheath showed that the intrarenal pressure was 80 cm of water column. In case of additional nephrostomic drainage, the volume of reverse suction of irrigation fluid was 6.7%. Conclusion. Nearly 100% of patients developed renal reflux during retrograde lithotripsy; presence of nephrostomy drainage reduced the volume of reverse suction of irrigation fluid by 4-5 times.
A Systematic Review of Nontuberculous Mycobacterium Infection Following Anterior Cruciate Ligament Reconstruction
Authors: Heifner John J. , Hunter Mitchell L. , Corces Arturo , Hommen Jan Pieter
Published: April 2023

Background:

Although infection following anterior cruciate ligament (ACL) reconstruction is rare, these cases have potentially catastrophic ramifications. Nontuberculous mycobacteria (NTM) are ubiquitous, located in the water supply and soil. Our objective was to review the literature to characterize NTM infection following ACL reconstruction.

Methods:

A database search was performed for arthroscopic ACL reconstructions that resulted in a postoperative diagnosis of NTM infection.

Results:

The literature search returned 6 case reports that met the inclusion criteria. The initial postoperative presentation occurred after 3 to 52 weeks, which is consistent with reports of postoperative NTM infection.

Conclusions:

The common indolent course of NTM infection hinders prompt diagnosis and treatment. Organism susceptibility testing is crucial for effective treatment and limiting unnecessary antibiotic exposure.

Clinical Relevance:

The duration of medical treatment for NTM infection is 4 to 6 months, depending on the severity of disease and species. Based on the aggregate literature, we recommend removal of local implants if the infection is localized and without articular involvement. However, in cases of articular involvement, all fixation and graft material should be removed.
Analisis Numerik Kekuatan Puntir Baja Karbon Rendah Menggunakan Software (Solidworks)
Authors: Affandi  , Huzni Syifaul
Published: April 2023

Salah satu komponen yaitu poros yang dikenai puntiran akan mengalami deformasi puntir. Semakin besar deformasi puntir menunjukkan kemampuan dari komponen mesin rendah, begitu sebaliknya. Permasalahan yang sering terjadi pada saat dilakukannya pengujian puntir adalah pengolahan data menjadi kurva tegangan-renggangan geser membutuhkan usaha yang tidak sedikit. Jika spesimen yang di gunakan adalah batang padat, maka akan timbul gradient tegangan yang cukup curam sepanjang penampang lintang spesimen sehingga mempersulit pengukuran. Objektif dari penelitian ini yaitu untuk mengetahui dan menganalisa pengujian kekuatan puntir pada baja karbon rendah dengan metode numerik menggunakan sofeware solidworks. Specimen uji puntir adalah baja karbon rendah dengan standart ASTM E-143. Metode penelitian ini diawali dengan studi literatur, menguji komposisi spesimen uji, membuat dan melakukan pemodelan spesimen uji puntir. Setelah itu dilakukan pengujian puntir yang selanjutnya dilakukan pengujian simulasi statik. Kemudian melakukan analisis kekuatan puntir dengan metode elemen hingga menggunakan software (solidworks). Berdasarkan hasil pembuatan geometri dan pemodelan spesimen uji puntir dengan standart ASTM E-143, bahwa distribusi tegangan yang terjadi pada permukaan area sudut spesimen memiliki nilai yang tidak terlalu signifikan berkisar 2.879e+09 N/m2 dan 2.973e+09 N/m2. Namun perlu dilakukan simulasi uji puntir software solidworkss dengan ukuran mesh yang bervariasi serta spesimen uji puntir dengan standart ASTM yang berbeda.
Bioremediation of reverse osmosis reject generated from the treatment of landfill leachate
Authors: Choudhury Atun Roy , Singh Neha , Palani Sankar Ganesh , Lalwani Jitesh
Published: April 2023

The moisture content of municipal solid waste (MSW) and local precipitation events lead to the leachate generation from MSW landfills. The high concentration of organic pollutants in landfill leachate makes it hazardous, requiring treatment before disposal into the environment. Landfill Leachate is most commonly treated by reverse osmosis (RO), which generates large volumes of wastewater termed as RO reject. This investigation aims to stabilize the RO reject through an inexpensive and effective bioremediation strategy. A bench-scale aerobic suspended growth reactor study was conducted using three commercial conversion agents, namely EM.1, Bokashi powder, and coir pith powder. Overall bench-scale efficacy of 63% was achieved in this study. The onsite studies were conducted in 7.5 kL artificial ponds with 46% efficacy amid atmospheric influences and constraints. In contrast, the control pond with no conversion agents showed an increase in pollution concentration over the 100 days of retention time. The findings revealed that the investigated technology had a marginally lower evaporation rate and performed relatively well compared to traditional solar evaporation ponds. Moreover, the technology can be easily scaled-up and readily applied for RO reject treatment in MSW landfills.
Ball-Milled Biochar Supported and Sulfidated Nanoscale Zerovalent Iron for Cr(VI) Removal
Authors: Hong Jie , Wei Lan , Wu Wei , Tan Jingying , Jia Siying , Clubb Preston , Rico Cyren M , He Feng
Published: April 2023

Hexavalent chromium, Cr(VI), is a common heavy metal that, if not remediated, will do great harm to the environment. Recently, nanoscale zerovalent iron (nZVI), a widely used water remediation nanomaterial, can be applied for Cr(VI) removal. In this study, ball-milled biochars (BM-BC) prepared from ball milling peanut shells biochar were reacted with FeCl3 and Na2S2O3·5H2O to synthesize S-nZVI@BM-BC (sulfidated nZVI supported on BM-BC). The S-nZVI:BM-BC mass ratio, solution pH, Cr(VI) concentrations, and dosage of S-nZVI@BM-BC were assessed for effectiveness of S-nZVI@BM-BC in eliminating Cr(VI) from water. The results showed that ball milling increased the oxygen content on the biochars surface. Both ball milling of biochar and sulfidation of nZVI enhanced the Cr(VI) removal capacity of S-nZVI@BM-BC at an optimized condition of 200 mg/L S-nZVI@BM-BC, pH 3, and Cr(VI) starting concentration of 10 mg/L. Further analysis revealed that reaction by-products Cr(III)/Fe(III) (oxy)hydroxides sorb on BM-BC composites for easy removal. These findings suggest that S-nZVI@BM-BC can be used in the remediation of chromium-contaminated water.
Long-term Outcomes Of Mitomycin-C Augmented Trabeculectomy using Subconjunctival Injections Versus Soaked Sponges: A Randomized Controlled Trial
Authors: Maheshwari Devendra , Pillai Madhavi , HM Priya , Rengappa Ramakrishnan , Kadar Mohideen , Pawar Neelam
Published: April 2023

Purpose: To compare the safety and efficacy of subconjunctival injection of Mitomycin C(MMC) with sponge-applied MMC during trabeculectomy.Methods: This prospective, randomized, interventional study was conducted on consecutive patients with uncontrolled glaucoma. 137 patients were randomized into an Injection group(Group 1,n=66) and a sponge group(Group 2,n=71). Trabeculectomy was performed in all patients who were followed up on days 1, 15, 30, 3 months,6 months,1 year,2 years & 3 years postoperatively. Baseline & follow-up visits were compared to find out difference in the number of antiglaucoma medications (AGM ), Intraocular pressure(IOP), and Best Corrected Visual Acuity(BCVA).In Group 1, the surgeon used MMC 0.2 mg/ml as subconjunctival injection and two separate semicircular surgical sponges soaked with MMC solution of 0.2 mg/mL were inserted subconjunctivally in Group 2.Results:Mean preop IOP was 34.21±13.3mmHg& 34.17±10.6mmHg in group 1&2 respectively,which reduced to 11.34±3.7& 12.57±4.7mmHg(6 months),11.97±4.2& 13.60 ±5.3mmHg(1year),12.42±4.4& 11.77±2.8 mmHg(2years)&11.25±3.2&11.81±3.2mmHg at final visit(P<0.001 in both groups)with no significant difference between the groups.The mean number of preoperative AGM was 2.32±0.7&2.32±0.8 in group1&2 respectively which reduced to 0.78±0.9(P<0.001)&1.13±1.1(P=0.930)at 3 years.Overall success rates were 75.3% in group 1 and 70.7% in group 2 at 3 years(p=0.512). Postoperative complications and the final post-operative visual outcomes were similar between the groups.Conclusion: Subconjunctival Injection of MMC is as safe and effective as sponge application with comparable surgical outcomes and complications in the long term.
The impact of lenvatinib on sarcopenia in patients with advanced unresectable hepatocellular carcinoma
Authors: Praktiknjo Michael , Solano Ana S. Pena , Sadeghlar Farsaneh , Welchowski Thomas , Schmid Matthias , Möhring Christian , Zhou Taotao , Mahn Robert , Monin Malte B. , Meyer Carsten , Feldmann Georg , Brossart Peter , Beekum Cornelius , Semaan Alexander , Matthaei Hanno , Manekeller Steffen , Sprinkart Alois M. , Nowak Sebastian , Luetkens Julian , Kalff Jörg C. , Strassburg Christian P. , -Carmona Maria A. Gonzalez
Published: April 2023

Lenvatinib is a multiple receptor tyrosine kinase inhibitor (TKI) approved for first-line treatment of patients with unresectable hepatocellular carcinoma (HCC). TKI are suspected of exacerbating muscle wasting (sarcopenia) in patients with cancer. In this study, we analyze the role of sarcopenia in patients with advanced HCC treated with lenvatinib. This is a retrospective analysis of a real-life cohort of 25 patients with advanced HCC who were treated with lenvatinib from 2018 to November 2020 in Germany. Patients were stratified for loss of skeletal muscle index (SMI) during the first three months of lenvatinib therapy. Overall survival (OS), progression-free survival (PFS) and toxicity were analyzed for all patients, especially regarding development of sarcopenia before and during the first three months of therapy with lenvatinib. Three months after beginning of therapy with lenvatinib, a significant reduction of muscle mass was observed in 60% of patients (p = 0.035). Despite increase of sarcopenia, patients benefitted from lenvatinib in our cohort of patients in terms of OS and PFS and did not experience increased toxicity. Furthermore, muscle loss was not found to be a negative predictor of survival in the univariate analysis. Patients with advanced hepatocellular carcinoma experience muscle wasting with lenvatinib therapy. However, despite progressive sarcopenia, patients benefit from a therapy with lenvatinib in terms of OS and PFS without increased toxicity. However, assessment and prophylaxis of skeletal muscle status should be recommended during a therapy with lenvatinib.
Determination of Survival-Related Factors in Coronary Artery Disease by Using Machine Learning Algorithms
Authors: Tanbakuchi Davoud , Ghavami Vahid , Mobarhan Majid Ghayour , Esmaily Habibollah
Published: April 2023

The aim of this study was to use machine learning methods in determining the factors related to the survival of heart patients in Mashhad. Because survival studies play an important role in medical and health research. Numerous methods have been used in this field and have been published in various magazines. Obviously, each of these methods has its drawbacks. accordingly, much research has been done to find algorithms that can meet the challenges. But so far none of them have been able to overcome all the challenges. In this research, our goal is to introduce algorithms that can overcome the challenges as much as possible and have the appropriate speed and accuracy. So, we first examine the theoretical issues of each method and introduce a series of the most practical machine learning methods in survival analysis. In addition, we will compare the performance of these methods with conventional and classical methods of survival analysis such as the Cox regression method. Then, while presenting the research results, we examine the strengths and weaknesses of each algorithm.
Urinary L-FABP: a potential novel early biomarker for Diabetic Nephropathy? A systematic review of the literature
Authors: Satta Ersilia , Strollo Felice , Borgia Luisa , Guarino Giuseppina , Romano Carmine , Masarone Mario , Gentile Sandro
Published: April 2023

Introduction:
Patients with Type 1 and Type 2 diabetes mellitus (T1DM and T2DM) are at high risk of developing chronic kidney disease (CKD), i.e., diabetic nephropathy (DN), whose onset and progression are associated with a high morbidity and mortality risk. Early DN prediction is crucial. Presently it relies on albumin excretion rate (AER) and glomerular filtration rate (GFR) assessment. Nevertheless, recent literature reports that DN eventually affects patients with normal AER and GFR values. Therefore, further cost-effective biomarkers of DN onset or fast worsening are needed. Intracellular liver-type fatty acid-binding protein (L-FABP) has been associated with renal tubular-interstitial damage and could help predict and diagnose DN.
Methods: we performed a systematic review of the literature to evaluate the performance of urinary excretion of such biomarker (uL-FABP) in predicting and diagnosing DN and its progression in T2DM and T1DM patients. To do so, we evaluated 635 publications on four major scientific databases, 21 of which were suited for inclusion in this review.
Results: we selected twenty-one in-extenso publications, 14 reporting a cross-sectional design/arm (nine on T2DM, four on T1DM, and one on both). Ten included a longitudinal design/arm. Cross-sectional studies, primarily conducted in Asian and north-European populations, showed uL-FABP levels to correlate directly with DN severity (micro-, macro-albuminuria, and overt CKD) in T1DM and T2DM, besides being significantly higher than in healthy controls in the case of normoalbuminuria. In addition, longitudinal ones showed baseline uL-FABP to predict DN onset in normoalbuminuric patients with T1DM and DN progression independently of diabetes type.
Discussion: the studies analyzed in this review suggest that uL-FABP is a marker of tubular damage detectable before increased albumin excretion and can represent the earliest sign of kidney dysfunction in diabetes. Indeed, it discloses DN onset and often predicts DN severity from start to end-stage renal disease (ESRD) in T2DM and T1DM patients. Currently, uL-FABP can be assessed on a routine basis and, being available as a point-of-care fast test kit, may also become an easy-to-handle diagnostic tool for outpatients.
Conclusions: uL-FABP represents a cost-effective and user-friendly biomarker of DN and can even predict DN progression in T2DM and T1DM over time.
Hemorrhagic fever with renal syndrome complicated by plasmacytosis mimicking multiple myeloma: A case report
Authors: Qian Long , Feng Ru , Wang Ting , Liu Hui , Bai Jiefei
Published: April 2023

Background Hemorrhagic fever with renal syndrome (HFRS) is a zoonosis endemic with atypical early clinical manifestations, and it is very easy to be misdiagnosed. Up to now, there has been no report on plasmacytosis caused by HFRS. Here we report a case of HFRS complicated by plasmacytosis mimicking multiple myeloma.Case presentation: We present an atypical case of HFRS, with the patient exhibiting both bone marrow and peripheral blood plasmacytosis during the course of illness. Besides, the patient presented with lymphadenopathy and was diagnosed with AITL and died soon due to cardiogenic shock.Conclusions HFRS should be one of differential diagnosis of plasmacytosis in certain endemic area.
Investigating an efficient processing strategy of SiCf/SiC composites during single grain scratching under minimum quantity lubrication.
Authors: Zhang Qi , Wang Ben , Song Chang , Wang Hao , Shi Zhongao
Published: April 2023

With the rapid development of processing technology, increasing processing efficiency is no longer the only goal but also the utilization of green and clean manufacturing procedures is required. In this context, the development of an efficient processing strategy for ceramic matrix composites (CMCs) is of great importance. Although SiCf/SiC composites are regarded as one of the most novel fiber-reinforced ceramic matrix composites, their processing is quite difficult. Along these lines, in this work, the orthogonal test of single-grain scratches was conducted under different lubrication modes. From the acquired results, it was demonstrated that compared with the dry type, the minimum quantity lubrication (vegetable oil) lubrication method exhibited the best effect, the scratch force was reduced by 48.3%, and the surface uplift height was reduced by 48.4%. The dominant mode of material removal of the SiCf/SiC composites was a brittle fracture, and the damage characteristics mainly included natural fiber fracture, matrix breakage, fiber pullout, and fiber exposure. In addition, the scratch depth and the scratch angle are the key factors affecting the processing quality. Increasing the processing ratio of 0° and using MQL (vegetable oil) have yielded the best results.