bluuebunny/crossref_metadata_2025 huggingface dataset:
Associated Factors of Marital Satisfaction in Iranian Women During the COVID-19 Pandemic: A Population-Based Study
Authors: Banaei Mojdeh , Safarzadeh Sanaz , Moridi Azam , Dordeh Mohammad , Dashti Sareh , Abdi Fatemeh , Roozbeh Nasibeh
Published: August 2021

Background: The increasing prevalence of COVID-19 in Iran has increased the risk for anxiety and stress in families. Due to the significance of the impact of family health on the society’s mental health and the fundamental role of marital relationships, which is an indicator of marital satisfaction, this study was conducted to investigate associated factors of marital satisfaction in Iranian women during the COVID-19 pandemic. Methods: This online cross-sectional study was carried out to assess associated factors of marital satisfaction in Iranian women during the COVID-19 pandemic from April 1 to April 20, 2020. The study sample consisted of 317 married women of childbearing age eligible to enter the study. Data were collected using a socio-demographic and obstetric questionnaire, the female sexual function index, the ENRICH Marital Satisfaction Scale, and the General Health Questionnaire. Data analysis was performed using SPSS software version 22. Results: A total of 317 married women participated in the study. The average age of the participants was 31.85 ± 6.94 years. Based on the multiple linear regression model, only five variables, including sexual satisfaction (B = 2.414, P < 0.001), physical symptoms (B = 0.245, P = 0.045), anxiety and insomnia (B = -0.319, P = 0.002), social dysfunction (B = 0.265, P = 0.003), and depression (B = -0.441, P < 0.001), could significantly predict marital satisfaction during the COVID-19 pandemic. Conclusions: Sexual satisfaction, physical symptoms, anxiety and insomnia, social dysfunction, and depression can significantly affect marital satisfaction during the COVID-19 pandemic. Therefore, planning to identify these factors and provide the appropriate strategy can increase marital satisfaction in times of crisis.
“Do You Read Me?”
Authors: Powell Tracy ,   Society for Phenomenology and Media
Published: August 2021

Inaccurate interpretation of negotiated nonverbal communication during an intimate encounter has serious moral and legal repercussions. Reciprocity between bodies allows one to assess the intention of the other. However, when the intended message is miscommunicated through the sender’s embodied action or misperceived by the receiver, a sexual assault can ensue. Understanding, conveying, and responding to behavioral gestures indicative of agreement or refusal to consent, is an emotional quagmire that has received global attention through sociopolitical movements such as #MeToo. Despite the desired cogitation of a pre-reflexive intentioned message, reciprocal navigation of a shared intimate space shifts within the corporeal/intercorporeal relationship, such that a habituated behavioral response, autonomic bodily responding, and socialized dating norms all have the potential to sabotage the essence of the original message. Seeking legal retribution is compromised in its application of objectified parameters to an ambiguous, subjective human interaction. While programs promoting slogans such as “Just Say No” are well intentioned, the complexity of human behavior, unconscious processes, and subjective perception, all suggest that communicating a refusal to consent extends far beyond the verbal utterance of saying “No.”
Processing of personal data relating to the health of the data subject in a pandemic situation
Authors: Rodriguez Ayuso Juan Francisco ,   Society for Phenomenology and Media
Published: August 2021

This study offers a systematic, exhaustive and updated investigation of the declaration of the state of alarm and the processing of personal data relating to the health of citizens affected and/or potentially affected by the exceptional situation resulting from COVID-19. Specifically, it analyses the distinction between the state of alarm and the states of exception and siege and the possible effect on the fundamental right to the protection of personal data in exceptional health crisis situations and the effects that this declaration may have on the applicable regulations, issued, at a Community level. Next, and taking into consideration all the general and sectorial regulations applicable to data protection and health, we proceed to the analysis of the legitimate bases and the exceptions that, applicable to situations of health emergency such as the present one, enable the processing, taking into account the nature of the person who intervenes as the controller, making special emphasis on the public interest pursued by the Public Administrations and on the vital interest of the interested party.
The Question of Disclosure in Photography
Authors: Inutsuka Junichiro ,   Society for Phenomenology and Media
Published: August 2021

Keeping aside discussions about theories of depiction of photography and the epistemic value of photography from the viewer’s perspective, I reconsider this techne from the photographers’ entire act of photographing. It presents the quest of the possibility to regain the world by the art of photography, especially in a situation where human consciousness of the living environment is overwhelmed by the photographic effects. The nature of the current technological environment—while disguising the manifestation of pure humanity, in the sense that it is the externalization of technology due to human nature—is completely destructive. Today, trying to save or regenerate philosophy should be nothing more than seeking a way for human beings to refuse being incorporated as an automaton in an endless track of automated reproduction processes. As one of those who wish to find a way to reconstruct the relationship between humans and nature or to reveal that human existence can only be established in such correlation, I seek a way of breathing human freedom, momentarily disputing this automated living and social environment. In other words, to regain or to play the art of photography, to unsettle what usually works as concrete support for the cognitive transformation making us unconsciously think of the technological environment as something inevitable and natural. It would be presenting a temporary retreat and a more positive way forward.
Thermodynamics of the Technosphere. Rethinking Temporality and Technicity in the Age of Planetary Emergency with Heidegger and Stiegler
Authors: Lemmens Pieter ,   Society for Phenomenology and Media
Published: August 2021

This article critically reflects on Stiegler’s re-interpretation of Heidegger’s views on the relationships between existential temporality, the understanding of being and technology within the context of the latter’s notion of enframing, reconceptualized as an explicitly planetary phenomenon: the technosphere. Stiegler replaces Heidegger’s ontological conception with an organological one, arguing that the latter fails to understand these phenomena from the crucial perspective of thermodynamics, i.e., of the question of entropy and negentropy, which has never been addressed by Heidegger. What I particularly aim to show is that Stiegler’s organological re-intepretation of enframing as the technosphere and of existential temporality in terms of ‘quasi-causality’ (per Deleuze) may profit from being put in the broader, geothermodynamic context of Earth System Science, and considered from the perspective of Schneider & Sagan’s ‘gradient theory’, as being driven by what may be called the planetary ‘thermodynamic imperative’ with Jeffrey Wicken.
Exceptionally preserved calcified sponge assemblagesin Upper Jurassic carbonates of the eastern Getic Carbonate Platform (Southern Carpathians, Romania)
Authors: PLEŞ George , SCHLAGINTWEIT Felix , LAZĂR Iuliana , BUCUR Ioan I. , SĂSĂRAN Emanoil , Mihaela GRĂDINARU undefined
Published: August 2021

A rich poriferan assemblage was identified within the easternmost part of the Getic Carbonate Platform of Romania (Grădiștei Gorges). The excellent preservation state of most poriferans here led to the discovery of a new species (Neuropora gigantea Pleș & Schlagintweit, n. sp.) and to the identification of previously unknown diagnostic features in some species (Sarsteinia babai Schlagintweit & Gawlick, 2006 emend., Neuropora lusitanica Termier, 1985, Sphaeractinia steinmanni Canavari, 1893). Calciagglutispongia yabei Reitner, 1992, Sarsteinia babai and Sphaeractinia steinmanni are reported for the first time from the Upper Jurassic carbonates of the Getic Carbonate Platform. The sedimentary input fluctuations and the nutrient competition had an important role in understanding the morphological adaptations of the analysed species. The existing palaeoecological and palaeoenvironmental conditions generated different distribution patterns towards the reef profile and also preferential adaptations to a specific Tethyan domain. As opposed to the poriferan assemblages from the northern Tethyan shelves, these organisms formed sponge-coral-microencruster boundstones at the margins and fore-reefal zones of isolated carbonate platforms within the intra-Tethyan realm. The importance of calcified sponges in reef-zonation is highlighted by the establishment of a general zonation model. Three zones can be distinguished: 1) Cladocoropsis-Milleporidium zone (back-reef area); 2) Bauneia-Chaetetopsis-Parastromatopora zone (central reef area); and 3) Sphaeractinia/Ellipsactinia-Neuropora zone for the fore-reef area. In the absence of a true reef framework these calcified sponges developed typical morphologies, environmental adaptations and partnerships with other biotic groups which strongly influenced the carbonate production throughout the intra-Tethyan domain.
A new tribe, two new genera and three new species of Cypridopsinae (Crustacea, Ostracoda, Cyprididae) from Brazil
Authors: Almeida Nadiny Martins , Higuti Janet , Ferreira Vitor Góis , Martens Koen
Published: August 2021

We describe one new tribe, two new genera and three new species of the subfamily Cypridopsinae Kaufmann, 1900 from Brazilian floodplains. Brasilodopsis gen. nov. belongs in the nominal tribe Cypridopsini, and both new species in this new genus were found in both sexual and asexual populations. Brasilodopsis baiabonita gen. et sp. nov. has a wide distribution and was found in three of the four major Brazilian floodplains. Brasilodopsis amazonica gen. et sp. nov. was recorded only from the Amazon floodplain. Brasilodopsis baiabonita gen. et sp. nov. has a subtriangular shape in lateral view, whereas Brasilodopsis amazonica gen. et sp. nov. is more elongated and has more rounded dorsal margins in both valves, as well as more pronounced external valve ornamentation, consisting of rimmed pores in shallow pits. Paranadopsis reducta gen. et sp. nov. was found in asexual populations in the Upper Paraná River floodplain only and differs from other Cypridopsinae in the more elongated carapace, an A1 with strongly reduced chaetotaxy (hence the specific name) and the total absence of caudal rami in females. Because of these strong reductions in valve and limb morphology, Paranadopsini trib. nov. is created within the Cypridopsinae for this intriguing new genus and species.
Laboratory Detection and Initial Diagnosis of Monoclonal Gammopathies
Authors: Keren David F. , Bocsi Gregary , Billman Brooke L. , Etzell Joan , Faix James D. , Kumar Shaji , Lipe Brea , McCudden Christopher , Montgomery Roberta , Murray David L. , Rai Alex J. , Redondo Teresita Cuyegkeng , Souter Lesley , Ventura Christina B. , Ansari Mohammad Qasim
Published: August 2021

Context.—

The process for identifying patients with monoclonal gammopathies is complex. Initial detection of a monoclonal immunoglobulin protein (M protein) in the serum or urine often requires compilation of analytical data from several areas of the laboratory. The detection of M proteins depends on adequacy of the sample provided, available clinical information, and the laboratory tests used.

Objective.—

To develop an evidence-based guideline for the initial laboratory detection of M proteins.

Design.—

To develop evidence-based recommendations, the College of American Pathologists convened a panel of experts in the diagnosis and treatment of monoclonal gammopathies and the laboratory procedures used for the initial detection of M proteins. The panel conducted a systematic literature review to address key questions. Using the Grading of Recommendations Assessment, Development, and Evaluation approach, recommendations were created based on the available evidence, strength of that evidence, and key judgements as defined in the Grading of Recommendations Assessment, Development, and Evaluation Evidence to Decision framework.

Results.—

Nine guideline statements were established to optimize sample selection and testing for the initial detection and quantitative measurement of M proteins used to diagnose monoclonal gammopathies.

Conclusions.—

This guideline was constructed to harmonize and strengthen the initial detection of an M protein in patients displaying symptoms or laboratory features of a monoclonal gammopathy. It endorses more comprehensive initial testing when there is suspicion of amyloid light chain amyloidosis or neuropathies, such as POEMS (polyneuropathy, organomegaly, endocrinopathy, M protein, and skin changes) syndrome, associated with an M protein.
El bullying desde el punto de vista del acosador: análisis y procedimiento
Authors: Tejada Eneko , Garay Urtza , Romero Ainara , Bilbao Naiara
Published: August 2021

Los centros de enseñanza poseen numerosos instrumentos para prevenir el acoso escolar, pero existe una gran escasez de medios para detenerlo desde una perspectiva pedagógica, cuando ya se ha originado. Esta investigación tiene por objeto diseñar un procedimiento eficaz que permita detener el bullying en esta situación y la muestra la conforman seis estudiantes de Educación Secundaria Obligatoria (ESO) identificados como acosadores escolares. Para el desarrollo de este estudio se ha adoptado una metodología de investigación acción, lo que ha facilitado el diseño de una herramienta anti-bullying, su implementación, la observación de cómo funciona y la valoración acerca de su incidencia y eficacia. El análisis de los datos ha sido cuantitativo y cualitativo, lo que ha permitido observar el efecto de las actividades en las conductas acosadoras en las seis sesiones llevadas a cabo y conocer el nivel de comprensión y tipo de pensamiento por el que pasa el acosador antes de dejar de agredir. De los resultados se extrae un procedimiento anti-bullying avanzado que constituye una propuesta válida para la intervención con el alumnado acosador y que contribuye a detener las conductas de acoso escolar.

Bullying is a type of violence that occurs in the educational environment and has great social repercussions. Schools have at their disposal different instruments to prevent bullying behaviour, however, there are not so many means to stop these behaviours at the time of their development. The aim of the present research is to analyze the incidence of an intervention composed by a sequence of metacognitive actions carried out with adolescent school bullies in order to design a better procedure that helps to stop bullying. An action research methodology has been carried out and the analysis of the data obtained has been of a quantitative and qualitative nature, which has allowed us to observe the effect of the bullying behaviours throughout the six sessions carried out and to know the type of thinking that the bully goes through before he stops the aggression. From the results of the research, a procedure has been extracted that constitutes a valid proposal for intervening with bullying students that contributes to stopping bullying behaviours
Análisis de la evaluación de programas de educación emocional y motivación en Educación Secundaria
Authors: Gutiérrez-de-Rozas Belén , Carpintero Molina Elvira
Published: August 2021

La motivación y las emociones son aspectos clave en el ámbito escolar debido a su clara relación con el rendimiento académico, y los programas de intervención se proponen como un recurso adecuado para contribuir a su mejora y ajuste. Sin embargo, seleccionar el programa adecuado y con garantías de calidad no siempre es una tarea sencilla. Una manera de obtener cierta garantía es partir de aquellos programas de intervención que no solo han sido evaluados, sino de los que además se dispone de evidencias de que dicha evaluación se ha realizado de forma correcta.
El presente trabajo tiene como objetivo analizar los procesos y resultados de evaluación de diferentes programas de educación emocional y de motivación dirigidos a estudiantes de Secundaria y/o adolescentes a partir de los resultados de sus evaluaciones. Para ello, se realiza una aproximación teórica a la evaluación y metaevaluación de programas y se lleva a cabo una revisión de la literatura académica de la que se seleccionan y comparan evaluaciones de programas de educación emocional y motivación. Finalmente, se realiza una metaevaluación mediante la aplicación de estándares.
Los resultados muestran que las evaluaciones se realizan, generalmente, de forma interna y sumativa, centrándose en los resultados de aplicación y no tanto en el proceso.

Motivation is a key aspect in education due to its influence on academic performance, and intervention programs are a useful resource to contribute to its improvement. However, selecting the right programme with quality guarantees is not always a simple task. One way to have a certain guarantee is by choosing those programs that have not only been evaluated, but for which there is also evidence that the evaluation has been performed correctly

The present work aims to analyse the evaluation processes and results of different motivational intervention programs addressed to Secondary students from the results of their evaluation results. In order to achieve this goal, a theoretical approach to program evaluation and meta-evaluation is made and a review of the academic literature from which evaluations of motivational intervention programs are selected and compared. Finally, a meta-evaluation is performed through the application of standards.

The results show that evaluations are generally conducted internally and in a summative manner, focusing on the results of implementation rather than on the process.
Archive, narrative, and loss
Authors: Strowe Anna
Published: August 2021

This article explores notions of loss in the archive through examples of archival materials related to translation, and the framework of narrative theory. Loss is seen as both a preliminary state prompting research and a result of research. Initially this article looks at these types of loss from a less theoretical perspective, before turning to sociological narrative theory as a conceptual framework that can both describe those types of loss and explain broader issues that arise in archival work, which are argued to be forms of narrative loss. Some existing discussions of archival work touch on the idea of narrative, but usually not in a specific enough way to provide a solid framework for the analysis and comparison of narratives themselves. By incorporating the narrative theory elaborated by Somers and Gibson (1994) and brought into translation studies by Baker (2006), I begin to explain how a narrative approach can both account for obvious types of loss and be used to conceptualize other forms of loss that occur in the process of preservation, transmission, and interpretation of archives.
Teaching with Children’s Literature in Initial Teacher Education: Developing Equitable Literacy Pedagogy through Talk about Books
Authors: Simpson Alyson
Published: August 2021

Teaching about children’s literature in pre-service teacher education is quite rare, even though research shows it is crucial for teachers to be good at teaching reading as well as being committed readers (Commeyras et al., 2003; Cremin et al., 2009). Emphasis on the reading process can sideline the importance of talking about quality literature to engage students in reading (Simpson, 2016). I have positioned the role of talk about books as a core part of the undergraduate program that I coordinate. In this way, the pre-service teachers of this study were alerted about the ‘fiction effect’ (Jerrim & Moss, 2019), which shows extended reading of literature has potential to improve reading skills for all students.
The paper explores how an initial teacher education course in Australia partnered with local schools to create interactions between school children and pre-service teachers talking about children’s literature. A dialogic approach to learning (Alexander, 2020) was adopted to teaching pre-service teachers to develop equitable literacy pedagogy working with children’s literature. Equity was used as a guiding principle to ensure pre-service teachers would provide children of all backgrounds and abilities the same opportunities to read literary texts. During their education program, the pre-service teachers received letters from school children who wrote about their reading preferences. The letters were discussed for evidence of reading habits and new books were sought as recommendations for children to read. By considering their own reading identities, pre-service teachers collectively developed their knowledge about children’s literature as they developed knowledge of literacy pedagogy. The scaffolding of habits of noticing through iterative discussion (Simpson et al., 2020) helped the pre-service teachers learn about their students, learn from their students, and encouraged them to take a more holistic view of the teaching of reading.
Identification of abscission checkpoint bodies as structures that regulate ESCRT factors to control abscission timing
Authors: Strohacker Lauren K , Mackay Douglas R , Whitney Madeline A , Couldwell Genevieve C , Sundquist Wesley I , Ullman Katharine S
Published: August 2021

The abscission checkpoint regulates the ESCRT membrane fission machinery and thereby delays cytokinetic abscission to protect genomic integrity in response to residual mitotic errors. The checkpoint is maintained by Aurora B kinase, which phosphorylates multiple targets, including CHMP4C, a regulatory ESCRT-III subunit necessary for this checkpoint. We now report the discovery that cytoplasmic abscission checkpoint bodies (ACBs) containing phospho-Aurora B and tri-phospho-CHMP4C develop during an active checkpoint. ACBs are derived from mitotic interchromatin granules, transient mitotic structures whose components are housed in splicing-related nuclear speckles during interphase. ACB formation requires CHMP4C, and the ESCRT factor ALIX also contributes. ACB formation is conserved across cell types and under multiple circumstances that activate the checkpoint. Finally, ACBs retain a population of ALIX, and their presence correlates with delayed abscission and delayed recruitment of ALIX to the midbody where it would normally promote abscission. Thus, a cytoplasmic mechanism helps regulate midbody machinery to delay abscission.
When a virus lies in wait
Authors: Taussig David , Wine Yariv
Published: August 2021

A mouse model supports the hypothesis that latent Epstein–Barr virus exacerbates the symptoms of rheumatoid arthritis.
iSUMOK-PseAAC: prediction of lysine sumoylation sites using statistical moments and Chou’s PseAAC
Authors: Khan Yaser Daanial , Khan Nabeel Sabir , Naseer Sheraz , Butt Ahmad Hassan
Published: August 2021

Sumoylation is the post-translational modification that is involved in the adaption of the cells and the functional properties of a large number of proteins. Sumoylation has key importance in subcellular concentration, transcriptional synchronization, chromatin remodeling, response to stress, and regulation of mitosis. Sumoylation is associated with developmental defects in many human diseases such as cancer, Huntington’s, Alzheimer’s, Parkinson’s, Spin cerebellar ataxia 1, and amyotrophic lateral sclerosis. The covalent bonding of Sumoylation is essential to inheriting part of the operative characteristics of some other proteins. For that reason, the prediction of the Sumoylation site has significance in the scientific community. A novel and efficient technique is proposed to predict the Sumoylation sites in proteins by incorporating Chou’s Pseudo Amino Acid Composition (PseAAC) with statistical moments-based features. The outcomes from the proposed system using 10 fold cross-validation testing are 94.51%, 94.24%, 94.79% and 0.8903% accuracy, sensitivity, specificity and MCC, respectively. The performance of the proposed system is so far the best in comparison to the other state-of-the-art methods. The codes for the current study are available on the GitHub repository using the link: https://github.com/csbioinfopk/iSumoK-PseAAC.
Effects of delivery via pressure-adjustable pneumatic gas-powered dart gun of three antimicrobial drugs (ceftiofur crystalline free acid, tildopirosin, and tulathromycin) on drug disposition and meat quality in cattle
Authors: Hairgrove Thomas B. , Fajt Virginia , Gill Ronald , Miller Rhonda , Miller Michael , Mays Travis
Published: August 2021

Background

Although Beef Quality Assurance guidelines do not recommend use of darting methods to deliver drugs, cattle in the US may be raised on farms and ranches without restraint facilities, and reports from the field suggest that dart guns are being used to deliver antimicrobial drugs. Few studies report whether this route of administration results in altered drug disposition or carcass quality.

Methods

Forty steers were blocked by sire and then randomly assigned to treatment with saline, ceftiofur crystalline free acid, tildipirosin, or tulathromycin delivered via dart gun. To assess drug disposition, eight ceftiofur, six tulathromycin, and six tildipirosin-treated calves were selected to measure plasma concentrations of drugs up to 10 days after drug administration. Steers were then fed a balanced ration for approximately 6.5 months and slaughtered. To evaluate carcass quality, tenderness of steaks from darted-side and non-darted sides was evaluated via Warner–Bratzler shear force testing. Due to the prohibition of extralabel routes of administration for ceftiofur in the U.S., animals treated with this drug did not enter the food supply.

Results

Ceftiofur disposition differed from published reports with lower mean Cmax but similar mean apparent elimination half-life. Tildipirosin disposition differed from published reports with lower Cmax and shorter apparent elimination half-life. Tulathromycin was similar to previous published reports but Cmax and apparent elimination half-life was highly variable. All steaks (from darted and non-darted sides) from cattle treated with ceftiofur and saline were more tender than from cattle treated with tulathromycin or tildipirosin (P = 0.003). There was a trend toward more tenderness in steaks from the non-darted compared to the darted side. Steaks from the darted side for one treatment, tildipirosin, were less tender than the non-darted side.

Conclusions

Pharmacokinetic parameters of ceftiofur crystalline free acid, tildipirosin, and tulathromycin to cattle using pressure-adjustable pneumatic gas-powered dart gun were estimated in this study. Delivery of tildipirosin and tulathromycin to cattle with dart gun may also result in detectable decreases in tenderness of harvested steaks.
Selection Approach for Indian Medical Residency Program: Perspective of Interns and Residents
Authors: Dulloo Puja
Published: August 2021

Introduction: Indian Postgraduate (PG) selection process has undergone various modifications since the past decade including the recent single nationalised entrance test initiated from April 2016. The perception of graduates and PGs for the type and process of selection test is not known. Aim: To study the perception of interns and residents regarding the process of the National Eligibility Cum Entrance Test for Postgraduates (NEET-PG) selection test. Materials and Methods: An exploratory qualitative thematic analytic study was conducted using purposive sampling with Semi-Structured Interviews (SSI), as per gender and academic grading, interns, and residents were selected. Eleven interns and ten first year residents took part. Braun and Clarke's six-phase thematic analysis framework was used for data analysis. Results: Three themes emerged; "building validity", "Proposed modifications" and "learning by the assessment". Validity building was related in terms of framing the multiple-choice questions, the format of the examination, and single attempt made per year. Different modifications were suggested by graduates and residents, in terms of assessment tools and strategies. Significant variations were observed in terms of learning by present assessment. Conclusion: The NEET-PG, a single nationalised assessment, appears to be well accepted with questioning for its validity in terms of assessment tool used, leading to restricted learning for the applicants. Participants widely proposed various assessment tools and methods for conducting a PG selection test for medical specialties. The NEET-PG assessment requires modification in terms of domains being assessed for the applicant so that it would improve patient care and safety. Selection authorities should pay weightage to the applicant's voice before framing the policies.
The Role of Cytogenetic Methods in the Diagnosis of Haematological Diseases
Authors: Aščerić Amina , Durović Mirela Mačkić , Nefić Hilada
Published: August 2021

Introduction: Conventional cytogenetics by the use of standard karyotyping allows the study of numerical and structural chromosomal aberrations. Haematological malignancies include a number of cancer types that originate in the blood cells of the bone marrow or of the lymphatic system. Cytogenetic methods are traditionally used for the sake of diagnosis and prognosis of these diseases. However, with the ever more frequent use of molecular methods in the diagnostic laboratories, the importance of the conventional cytogenetic analysis in the diagnosis of haematological diseases needs to be reassessed. Aim: To evaluate the role of cytogenetic methods in the diagnosis of haematological malignancies. Materials and Methods: A retrospective analysis of cytogenetic findings of 146 patients with various haematological malignancies was performed. All of the findings were made over a period of three years at the Centre for Genetics at the Medical Faculty of the University of Sarajevo in Bosnia and Herzegovina. Microsoft Excel 2019 was used for the analysis and presentation of data in the form of tables and graphs. Results: The results of the present study showed that the use of conventional cytogenetic analysis is a good diagnostic method for 50.68% (74) of patients in whom chromosomal aberrations were detected. Conclusion: Cytogenetics remains the most comprehensive method for assessing chromosomal abnormalities due to its ability to detect clinically relevant aneuploidies and additional cytogenetic abnormalities that cannot be detected by locus-specific assays.
Pervasiveness and Epidemiological Profile of SARS-CoV-2 Infection among the Population of Majha Region of Punjab,India
Authors: Kaur Harsimrat , Singh Ravinder , Singh Kanwardeep , Kaur Savjot , Jairath Mohan , Sidhu Shailpreet Kaur
Published: August 2021

Introduction: There are many types of coronaviruses that causes respiratory and intestinal infection in humans. Among these coronaviruses, is a group of Severe Acute Respiratory Syndrome (SARS)-like bat coronavirus, including both SARS-CoV and SARS-Cov-2 that comprise a unique clade under the subgenus Sarbecovirus. The SARS-CoV-2 strains in India are more closely related to bat-CoVRaTG13 (93% homology) than pangolin CoV (83.5% homology). India reported its first case of Coronavirus Disease 19 (COVID-19) on January 30, 2020. Punjab, a state in northwestern India comprises of 22 districts which are classified into three major distinct regions viz. Majha, Malwa and Doaba. Four districts of Majha region of Indian state of Punjab are Amritsar, Tarn Taran, Gurdaspur and Pathankot. Aim: The present study describes the SARS-CoV-2 epidemiology based on samples tested for this virus; received at Viral Research and Diagnostic Laboratory (VRDL), Government Medical College, Amritsar-Punjab, India. Materials and Methods: This epidemiological study was designed taking into consideration three main factors i.e. the gender, the age groups and the factor whether the individual has any symptoms or not. To study their context of applicability and its interpretation, a total of 3,47,418 samples from period of 01st April 2020 to 31st October 2020 were included in this study. Ribonucleic Acid amplification by Reverse Transcriptase Polymerase Chain Reaction (RT-PCR) of SARS-CoV-2 from nasopharyngeal/oropharyngeal swabs of all individuals revealed confirmation of 17,920 positive samples. Total 2,29,310 males and 1,18,108 females were tested for the COVID-19 infection. Social science statistics online tool (https://www.socscistatistics.com/tests/) was used for χ2 test to analyse different parameters. Results: Maximum number of COVID-19 positive patients was detected in 21 to 30 years age group (p<0.05). Highest positivity ratio of samples was observed in individuals exceeding the age of 50 years. Number of asymptomatic individuals was found to be quite higher than symptomatic individuals in total population. Overall percent positivity of asymptomatic individuals was 4.81% (p<0.00001), which accounts to 4.71% of total number of tested individuals in this study. Conclusion: COVID-19 is an evolving disease and data from this study elucidates the epidemiological profile of the SARS-CoV-2 infection among population of Majha region of Punjab state of Indian subcontinent.
Persistence of Symptoms after Acute COVID-19 Infection- An Experience from a Tertiary Care Centre in South India
Authors: Areekal Binu , Sukumaran Sudhiraj Thiruthara , Andrews Andrews Mekkattukunnel , Nanu Sreejith Parayil , Madhavan Indira , Veepanattu Pranav , Parambath idhin Raj , Solomon Jobin Palluruthil
Published: August 2021

Introduction: Coronavirus Disease-19 (COVID-19) pandemic is posing a challenge not only with sheer number of people infected but also with the large number of patients with persistent symptoms of COVID-19 infection. A proper understanding of the magnitude and associated factors of persistent COVID-19 symptoms will go a long way in planning treatment and control strategies. Aim: To determine the proportion of patients who have persistent symptoms post acute COVID-19 infection and to determine the factors associated with it, among those who have been discharged from Government Medical College, Thrissur, Kerala, India. Materials and Methods: The current cross-sectional study was conducted among 335 patients who were admitted and discharged with COVID-19 infection in Government Medical College, Thrissur, Kerala, a tertiary care institution in southern India between December 2020 and February 2021. They were contacted through a telephonic interview 28 days from symptom onset through a semi-structured interview schedule. The questions included basic demographic details, symptomatology at admission, persistent symptoms at 28 days after onset and other clinical details including comorbidities. For defining post COVID-19 symptom persistence National Institute for Health and Care (NICE) guidelines were used. Association between persistent symptoms and selected factors was done by Chi-square test. Results: Out of the 335 patients, the persistence of symptoms of COVID-19 infection after 28 days of symptom onset was 221 (66%) (CI 60.7-79.8). Persistence of two or more COVID-19 symptoms after 28 days of onset was seen in 120 (35.8%). The most common persistent symptoms among the patients were fatigue in 109 (32.5%) of people followed by dyspnoea in 77 (23%), cough in 45 (13.4%) and myalgia in 37 (11%) patients. Highest persistence was seen in Category C patients where symptoms were persisting in 75%. Persistence was also higher in those with Diabetes Mellitus (DM), those who received oxygen support and those who were in Intensive Care Unit (ICU) or on ventilator and the association was statistically significant (p-value <0.05). Conclusion: The study shows that two-third of patients still continues to have persistent symptoms even after 28 days of symptom onset. Health systems should be prepared to face the consequences of morbidities caused by post COVID-19 syndrome.
Case Report on Rheumatoid Arthritis
Authors: Dhanvijay Roshani , Pohekar Savita
Published: August 2021

Rheumatoid arthritis (RA) is an autoimmune disorder that inhibits the body's immune system that induces inflammation in the injured areas of the body. It is commonly caused the joints of the palms, wrists, and knees. An inflaming rheumatoid arthritis joint contributes to joint tissue damage. This condition may cause chronic or long term discomfort, instability, and deformation. Symptoms include exhaustion, pain, and depression. If the patient does not undergo early diagnosis and care for symptoms, a series of symptoms can arise including Osteoporosis, rheumatoid nodules, dry eye and mouth, carpal tunnel syndrome Case Report: The female patient name is Yogita Shinde 65-year-old religion Hindu lived in the kandhali. She was admitted to AVBR Hospital with the chief complaint of pain in her shoulder and hands, joints pain, swelling on both the hands. She started taking ibuprofen 800 mg 3 times per day to relieve discomfort and rigidity.  Three months earlier, as she was doing her job, she had pain on her right and left shoulders. She still started to feel very sleepy and short-tempered. Tab ibuprofen was not an effective very long time for pain.  One morning, Yogita couldn't lift her arms without the intense pain of her back. She was conscious that it was time for help. She had spoken to her parents, and they advised her to see a physician. The primary healthcare practitioner (PHP), who tested and carried out a variety of blood test. Positive-rheumatoid factors, CCP antibiotics, higher ESR, and C-reactive protein were seen via the blood samples. These findings were communicated to Yogita and the Rheumatologist was directed at her PCP to see her as soon as possible. The primary health care practitioner inquired about the medical records of Yogita parents and grandparents, family conditions, medical and operative records of yogita, and details on their family and working lives. And after that, the physician started the treatment, after which Yogita feels better for some days. After a few weeks she having recurrent pain in her hand and foot, this is intolerable to her. And then she is admitted to AVBR Hospital on date 20th Sept 2020
Assessment of Aliskiren Hemifumarate and Amlodipine Besylate in combined Tablet Dosage form by Three Simple UV Spectrophotometric Methods
Authors: Sen Ashim K. , Sen Dhanya B. , Zanwar Aarti S. , Maheshwari Rajesh A. , Balaraman R.
Published: August 2021

Background: For a cardiovascular patient's blood pressure to be effectively controlled, more than one drug is required. When coupled with amlodipine besylate (AMLO), a calcium channel blocker, Aliskiren hemifumarate (ALI) is the 1st nonpeptide, low molecular mass, orally active transition state rennin inhibitor to efficaciously normalize blood pressure and cardiac ailments.

Objective: Three innovative, easy, sensitive, exact, and accurate UV spectrophotometric approaches, including simultaneous equation method (SEM), absorbance ratio method (ARM) and 1st derivative (zero-crossing) spectroscopic approach (FDR), were created and authenticated by validation for synchronized estimation of ALI and AMLO in tablet formulation.

Materials and Methods: The SEM was used to measure the absorbance of both medicines at 237 and 280 nm. ALI and AMLO were calculated using 237 and 271 nm, respectively, in the ARM. ALI and AMLO, on the other hand, used the FDR technique to transform UV spectra to first derivative spectra, with the first derivative signal captured at 237 and 254 nm, respectively. The wavelength interval (Δλ) was kept at 2 and the scaling factor was kept at 1 when transforming zero-order spectra using the first derivative approach. Validation of the proposed processes was done in compliance with the “International Conference on Harmonization” (ICH) recommendations. Results: SEM and ARM both showed a linear outcome in the range of 1-50 µg/ml for ALI and AMLO. FDR, on the other hand, was shown to be more sensitive and linear between 0.5 and 50 µg/ml for both medications. The results of the method validation parameters were within the allowed ranges of the ICH guidelines.

Conclusion: The proposed procedures were shown to be relatively quick, sensitive, simple, and cost-effective, and can thus be used for scheduled quality control analysis of ALI and AMLO in the mixed tablet.
The Role of Radiographic Imaging in Diagnosis and Follow-up of Vesicoureteral Reflux: Review Article
Authors: Fadl Mahmoud Elsayed Mahmoud , Almutairi Anwar Suwailem , Alshalan Amal Muteb S.
Published: August 2021

Background: Primary vesicoureteral reflux is a basic influencing for urinary tract infections in children. The basic technique for the diagnosis of vesicoureteral reflux is voiding cystourethrography, accompanied with cystoscintigraphy. Voiding cystourethrography has the benefit of only minor irradiation. However it does no longer permit the morphological assessment of bladder and vesicoureteral reflux grading. Colored-Doppler cystosonography with echocontrast is a currently delivered technique for imaging vesicoureteral reflux. The purpose of our study is to explore the role of Radiographic Imaging in diagnosis and follow‐up of vesicoureteral reflux.

Method: A systematic review was carried out, (including PubMed, Google Scholar, and EBSCO) of imaging modalities used to detect or evaluate vesicoureteral reflux disease. The found articles were screened by titles, and abstracts. No software will be utilized to analyze the data. The review was performed by the group members and each verified by at least two, to ensure the validity and minimize the mistakes.

Results and Conclusion: Colour-Doppler cystosonography, due to the nonexistence of ionizing radiations, has great benefits, mainly in cases requiring continued or prolonged monitoring. In spite of practices stated in the literature, this procedure has a role in the diagnosis of vesicoureteral reflux. Our group chooses colour-Doppler cystosonography for the follow-up of medium-severe grade vesicoureteral reflux previously diagnosed by radiology and/or scintigraphy. Cystoscintigraphy is used only to confirm cases resulting negative at ultrasonography.
Evaluation of in vivo Wound Healing Activity of Ursolic Acid Rich Chloroform Extract of Hedyotis herbacea Linn Ointment
Authors: Babu K. Anand , Sivakrishnan S. , Jasemine S.
Published: August 2021

Aim: This study evaluates the effect of in vivo wound healing potential of Ursolic acid rich chloroform extract of Hedyotis herbacea Linn ointment using incision and excision wound model.

Study Design: Wound healing potentials of Hedyotis herbacea were analysed by Incision and excision wound model.

Place of Study: Nandha College of Pharmacy, Erode, Tamilnadu.

Methodology: Hedyotis herbacea was subjected to extraction (cold maceration), with solvents of increasing polarity. All the extracts were estimated for the presence of phytoconstituents by HPTLC. As the study has been focused on the phytoconstituent based biological activity, the Ursolic acid rich chloroform extract was chosen for the study of wound healing activity. The Chloroform extract of Hedyotis herbacea was incorporated into ointment base, to prepare the ointment. The ointments prepared with Chloroform extract (2.5% and 5%) of Hedyotis herbacea (CEHH) were subjected for evaluation of excision and incision wound model. Wistar albino rats were divided into four groups each consisting of six animals; group I (left untreated) considered as untreated control, group II treated with 5% w/w povidone-iodine ointment served as standard, group III treated with CEHH 2.5% w/w ointment, and group IV treated with CEHH 5% w/w ointment were considered as test groups. All the treatments were given once daily. Wound healing effect was assessed by the rate of wound contraction, level of total protein, Hydroxy proline, Hexosamine and Hexuronic acid and histopathology studies in an excision wound model. Tensile strength was also measured in both excision and incision wound.

Results: Wound healing activity of CEHH 5% w/w ointment treated group was greater than CEHH 2.5% w/w and untreated groups in both excision and incision wound model. The high rate of wound contraction (*P< 0.001), high tensile strength (*P< 0.001), and elevated total protein, Hydroxyproline, Hexosamine, and Hexuronic acid content were observed in animals treated with CEHH ointments when compared to the untreated control group of animals. Histopathological studies of the CEHH ointments treated groups also revealed the effectiveness in wound healing.

Conclusion: These results justified the claimed traditional use of the Hedyotis herbacea as wound healing plant.
A Case Report on Pulmonary Effusion due to Non-Hodgkin’s Disease
Authors: Selsurkar Sarika
Published: August 2021

Introduction: In patients with non- Hodgkin's disease, pleural effusion is not an unusual finding, with a recorded incidence of up to 20 percent. The effusion can be unilateral or bilateral, and the fluid causes symptoms of dyspnoea, cough, and/or chest pain in most patients.

Case Presentation: A 17 years male was admitted in AVBRH with the chief complaint of chest pain since 4 days on one side which radiated to left shoulder, breathlessness from 2 days on walking and cough from 1 month. Patient had no complaint of fever, cold, abdominal pain,        vomiting, orthopnia or trauma. The patient had done all necessary investigations by physician order.

Therapeutic Intervention, Management and Outcomes: Patient was treated with oxygen therapy, chemotherapy, Thoracentesis and anticoagulant, antibiotics medication.

Nursing Management: Administered fluid replacement i.e. RL, oxygen therapy 15 litres per minute, chemotherapy, monitored all vital signs half hourly.

Conclusion: Timely treatment and management of Pleural effusion with non-Hodgkin’s disease can bring out successful recovery with limited complications.
Assessing of the Risk Factor & Determine Epidemiology of Acne Vulgaris in Tertiary Care Teaching Hospital
Authors: Hadia Rajesh , Tousif Idrisi Mohammed , Kapadia Avani , Pillai Suchitra , Rajput Hemraj Singh , Joshi Dhaval , Lakhani Som , Gohel Kushalkumar , Maheshwari Rajesh
Published: August 2021

Background: Acne vulgaris remains one of the commonest diseases to afflict humanity, with over 90% of males and 80% of females affected by the age of 21 years.

Objectives: The aim of this study was to assessing the specific risk factors, determine the epidemiology and etiology of Acne Vulgaris.

Methodology: It is a cross-sectional observational study conducted for a period of six month in the department of dermatology, Dhiraj General Hospital, Vadodara. Patients who were diagnosed with acne vulgaris and fulfilled the inclusion criteria were enrolled in the study. Data was collected by filling the patient medical record sheet.

Result: Total 300 patients were included in the study. Out of which 38.67% males and 61.33% females were found affected by Acne Vulgaris. The mean age group affected were found to be 21.77±4.06 years. When compared their social habits, patients consumed more caffeine (49.67%) than alcohol (24.67%), smoking (15.33%) and tobacco (5.67%). 32.33% patients also had history of seborrheic dermatitis. Using GAGS scale, we found 94% patients suffered from moderate Acne condition while 6% suffered from severe Acne condition.

Conclusion: Acne Vulgaris was predominantly found in females in adolescence and in males in adulthood. The severity was found more in males than females. The common site for Acne Vulgaris was found to be face while comedones and papules were the common types of lesions. Stress was found to be one of the major aggravating factors for severity of Acne Vulgaris.