bluuebunny/crossref_metadata_2025 huggingface dataset:
The Genetic and Environmental Adaptation of the Associated Liana Species Derris trifoliata Lour. (Leguminosae) in Mangroves
Authors: Zhang Yun , Xin Kun , Liao Baowen , Ai Xihang , Sheng Nong
Published: October 2021

Derris trifoliata Lour. is an indigenous and associated liana species of mangroves in China; however, its rapid dispersal is threatening mangrove survival. To explore and evaluate their persistence in past disturbances and their potential resistance to future climate and environmental changes, 120 D. trifoliata samples were collected from three sites in Guangdong Province, China, and they were used to develop single nucleotide polymorphic markers using specific-locus amplified fragment sequencing technology. A total of 351.59 Mb reads and 97,998 polymorphic specific-locus amplified fragment sequencing tags were identified, including 360,672 single nucleotide polymorphisms. The principal component analysis, phylogenetic tree, and genetic structure all clustered the samples according to their geographic positions. The three populations showed medium genetic diversity levels and high clonal diversity, indicating that sexual propagation played vital roles in the populations’ succession, although clonal growth was intense within the populations. An association analysis revealed that 9 out of 16 markers were correlated with nitrogen, which indicated the positive roles of nitrogen in population formation and maintenance. This study provides an ecological and molecular basis for understanding the outbreaks of D. trifoliata in mangroves. To control the further expansion of D. trifoliata in mangroves, preventive and control measures should be taken against clonal growth and sexual propagation, respectively; obstructing the clonal growth, especially that of the stolon, should be mainly considered at the junctions of D. trifoliata and mangroves.
Drought Stress Described by Transcriptional Responses of Picea abies (L.) H. Karst. under Pathogen Heterobasidion parviporum Attack
Authors: Yeoh Xenia Hao-Yi , Durodola Blessing , Blumenstein Kathrin , Terhonen Eeva
Published: October 2021

The major threats to the sustainable supply of forest tree products are adverse climate, pests and diseases. Climate change, exemplified by increased drought, poses a unique threat to global forest health. This is attributed to the unpredictable behavior of forest pathosystems, which can favor fungal pathogens over the host under persistent drought stress conditions in the future. Currently, the effects of drought on tree resistance against pathogens are hypothetical, thus research is needed to identify these correlations. Norway spruce (Picea abies (L.) H. Karst.) is one of the most economically important tree species in Europe and is considered highly vulnerable to changes in climate. Dedicated experiments to investigate how disturbances will affect the Norway spruce—Heterobasidion sp. pathosystem are important, in order to develop different strategies to limit the spread of H. annosum s.l. under the predicted climate change. Here, we report a transcriptional study to compare Norway spruce gene expressions to evaluate the effects of water availability and the infection of Heterobasidion parviporum. We performed inoculation studies of three-year-old saplings in a greenhouse (purchased from a nursery). Norway spruce saplings were treated in either high (+) or low (−) water groups: high water group received double the water amount than the low water group. RNA was extracted and sequenced. Similarly, we quantified gene expression levels of candidate genes in biotic stress and jasmonic acid (JA) signaling pathways using qRT-PCR, through which we discovered a unique preferential defense response of H. parviporum-infected Norway spruce under drought stress at the molecular level. Disturbances related to water availability, especially low water conditions can have negative effects on the tree host and benefit the infection ability of the pathogens in the host. From our RNA-seq analysis, 114 differentially expressed gene regions were identified between high (+) and low (−) water groups under pathogen attack. None of these gene pathways were identified to be differentially expressed from both non-treated and mock-control treatments between high (+) and low (−) water groups. Finally, only four genes were found to be associated with drought in all treatments.
Electroencephalography (EEG)-Based Neural Emotional Response to the Vegetation Density and Integrated Sound Environment in a Green Space
Authors: Zeng Chengcheng , Lin Wei , Li Nian , Wen Ya , Wang Yanxin , Jiang Wenyuan , Zhang Jialing , Zhong Haolin , Chen Xin , Luo Wenhao , Chen Qibing
Published: October 2021

Emotion plays an important role in physical and mental health. Green space is an environment conducive to physical and mental recovery and influences human emotions through visual and auditory stimulation. Both the visual environment and sound environment of a green space are important factors affecting its quality. Most of the previous relevant studies have focused solely on the visual or sound environment of green spaces and its impacts. This study focused on the combination of vegetation density (VD) and integrated sound environment (ISE) based on neural emotional evaluation criteria. VD was used as the visual variable, with three levels: high (H), moderate (M) and low (L). ISE was used as the sound variable, with four levels: low-decibel natural and low-decibel artificial sounds (LL), low-decibel natural and high-decibel artificial sounds (LH), high-decibel natural and low-decibel artificial sounds (HL) and high-decibel natural and high-decibel artificial sounds (HH). These two variables were combined into 12 unique groups. A total of 360 volunteer college students were recruited and randomly assigned to the 12 groups (N = 30). All 12 groups underwent the same 5 min high-pressure learning task (pretest baseline), followed by a 5 min audio-visual recovery (posttest). Six indicators of neural emotion (engagement, excitement, focus, interest, relaxation and stress) were dynamically measured by an Emotiv EPOC X device during the pretest and posttest. Analysis of covariance was used to determine the main and coupled effects of the variables. (1) VD and ISE have significant effects on human neural emotions. In moderate- and high-VD spaces, artificial sound levels may have a positive effect on excitement. (2) A higher VD is more likely to result in excitatory neural emotion expression. (3) Low-VD and high-VD spaces have a higher degree of visual continuity. Both extremely low and extremely high VDs result in a higher expression of stressful emotions than observed for a moderate VD. (4) High-decibel artificial sounds are more likely to attract attention, possibly because artificial sounds are easier to recognize than natural sounds. However, when both the natural and artificial sounds are low, it is difficult to induce higher tones, and the lower the artificial sound decibel level, the easier it is to relax. Additionally, under the influence of an ISE, attention recovery and stress recovery may be negatively correlated. The results show that an appropriate combination of VD and ISE can improve the health benefits of a green space and thus the well-being of visitors.
On Predicting Ticket Reopening for Improving Customer Service in 5G Fiber Optic Networks
Authors: Ricciardi Celsi Lorenzo , Caliciotti Andrea , D'Onorio Matteo , Scocchi Eugenio , Sulieman Nour Alhuda , Villari Massimo
Published: October 2021

The paper proposes a data-driven strategy for predicting technical ticket reopening in the context of customer service for telecommunications companies providing 5G fiber optic networks. Namely, the main aim is to ensure that, between end user and service provider, the Service Level Agreement in terms of perceived Quality of Service is satisfied. The activity has been carried out within the framework of an extensive joint research initiative focused on Next Generation Networks between ELIS Innovation Hub and a major network service provider in Italy over the years 2018–2021. The authors make a detailed comparison among the performance of different approaches to classification—ranging from decision trees to Artificial Neural Networks and Support Vector Machines—and claim that a Bayesian network classifier is the most accurate at predicting whether a monitored ticket will be reopened or not. Moreover, the authors propose an approach to dimensionality reduction that proves to be successful at increasing the computational efficiency, namely by reducing the size of the relevant training dataset by two orders of magnitude with respect to the original dataset. Numerical simulations end the paper, proving that the proposed approach can be a very useful tool for service providers in order to identify the customers that are most at risk of reopening a ticket due to an unsolved technical issue.
A Dynamic Service Reconfiguration Method for Satellite–Terrestrial Integrated Networks
Authors: Qiao Wenxin , Lu Hao , Lu Yu , Meng Lijie , Liu Yicen
Published: October 2021

Satellite–terrestrial integrated networks (STINs) are regarded as a promising solution to meeting the demands of global high-speed seamless network access in the future. Software-defined networking and network function virtualization (SDN/NFV) are two complementary technologies that can be used to ensure that the heterogeneous resources in STINs can be easily managed and deployed. Considering the dual mobility of satellites and ubiquitous users, along with the dynamic requirements of user requests and network resource states, it is challenging to maintain service continuity and high QoE performance in STINs. Thus, we investigate the service migration and reconfiguration scheme, which are of great significance to the guarantee of continuous service provisioning. Specifically, this paper proposes a dynamic service reconfiguration method that can support flexible service configurations on integrated networks, including LEO satellites and ground nodes. We first model the migration cost as an extra delay incurred by service migration and reconfiguration and then formulate the selection processes of the location and migration paths of virtual network functions (VNFs) as an integer linear programming (ILP) optimization problem. Then, we propose a fuzzy logic and quantum genetic algorithm (FQGA) to obtain an approximate optimal solution that can accelerate the solving process efficiently with the benefits of the high-performance computing capacity of QGA. The simulation results validate the effectiveness and improved performance of the scheme proposed in this paper.
Opportunities and Challenges to Improve a Public Research Program in Plant Breeding and Enhance Underutilized Plant Genetic Resources in the Tropics
Authors: Cerón-Souza Ivania , Galeano Carlos H. , Tehelen Katherine , Jiménez Hugo R. , González Carolina
Published: October 2021

The American tropics are hotspots of wild and domesticated plant biodiversity, which is still underutilized by breeding programs despite being conserved at regional gene banks. The improvement of those programs depends on long-term public funds and the maintenance of specialized staff. Unfortunately, financial ups and downs complicate staff connectivity and their research impact. Between 2000 and 2010, Agrosavia (Corporación Colombiana de Investigación Agropecuaria) dramatically decreased its public financial support. In 2017, we surveyed all 52 researchers from Agrosavia involved in plant breeding and plant genetic resource programs to examine the effect of decimating funds in the last ten years. We hypothesized that the staff dedicated to plant breeding still suffer a strong fragmentation and low connectivity. As we expected, the social network among researchers is weak. The top ten central leaders are predominantly males with an M.Sc. degree but have significant experience in the area. The staff has experience in 31 tropical crops, and 17 are on the list of underutilized species. Moreover, although 26 of these crops are in the national germplasm bank, this has not been the primary source for their breeding programs. We proposed five principles to improve connectivity among teams and research impact: (1) The promotion of internal discussion about gender gaps and generation shifts to design indicators to monitor and decrease this disparity over time. (2) The construction of long-term initiatives and synergies with the Colombian government to support the local production of food security crops independent of market trends. (3) Better collaboration between the National Plant Germplasm Bank and plant breeding researchers. (4) A concerted priority list of species (especially those neglected or underutilized) and external institutions to better focus the collaborative efforts in research using public funds. (5) Better spaces for the design of projects among researchers and training programs in new technologies. These principles could also apply in other tropical countries with public plant breeding research programs facing similar challenges.
The Genetic Landscape of Mitochondrial Diseases in Spain: A Nationwide Call
Authors: Bellusci Marcello , Paredes-Fuentes Abraham J , Ruiz-Pesini Eduardo , Gómez Beatriz ,   MITOSPAIN Working Group, Martín Miguel A , Montoya Julio , Artuch Rafael
Published: October 2021

The frequency of mitochondrial diseases (MD) has been scarcely documented, and only a few studies have reported data in certain specific geographical areas. In this study, we arranged a nationwide call in Spain to obtain a global estimate of the number of cases. A total of 3274 cases from 49 Spanish provinces were reported by 39 centres. Excluding duplicated and unsolved cases, 2761 patients harbouring pathogenic mutations in 140 genes were recruited between 1990 and 2020. A total of 508 patients exhibited mutations in nuclear DNA genes (75% paediatric patients) and 1105 in mitochondrial DNA genes (33% paediatric patients). A further 1148 cases harboured mutations in the MT-RNR1 gene (56% paediatric patients). The number of reported cases secondary to nuclear DNA mutations increased in 2014, owing to the implementation of next-generation sequencing technologies. Between 2014 and 2020, excepting MT-RNR1 cases, the incidence was 6.34 (95% CI: 5.71–6.97) cases per million inhabitants at the paediatric age and 1.36 (95% CI: 1.22–1.50) for adults. In conclusion, this is the first study to report nationwide epidemiological data for MD in Spain. The lack of identification of a remarkable number of mitochondrial genes necessitates the systematic application of high-throughput technologies in the routine diagnosis of MD.
A Low-Cost, High-Throughput Digital Image Analysis of Stain Patterns on Smoked Cigarette Filter Butts to Estimate Mainstream Smoke Exposure
Authors: Watson Clifford H. , Yan Jane , Stanfill Stephen , Valentin-Blasini Liza , Bravo Cardenas Roberto , Blount Benjamin C.
Published: October 2021

Standard machine smoking protocols provide useful information for examining the impact of design parameters, such as filter ventilation, on mainstream smoke delivery. Unfortunately, their results do not accurately reflect human smoke exposure. Clinical research and topography devices in human studies yield insights into how products are used, but a clinical setting or smoking a cigarette attached to such a device may alter smoking behavior. To better understand smokers’ use of filtered cigarette products in a more natural environment, we developed a low-cost, high-throughput approach to estimate mainstream cigarette smoke exposure on a per-cigarette basis. This approach uses an inexpensive flatbed scanner to scan smoked cigarette filter butts and custom software to analyze tar-staining patterns. Total luminosity, or optical staining density, of the scanned images provides quantitative information proportional to mainstream smoke-constituent deliveries on a cigarette-by-cigarette basis. Duplicate sample analysis using this new approach and our laboratory’s gold-standard liquid chromatography/tandem mass spectrometry (LC/MS/MS) solanesol method yielded comparable results (+7% bias) from the analysis of 20 commercial cigarettes brands (menthol and nonmentholated). The brands varied in design parameters such as length, filter ventilation, and diameter. Plots correlating the luminosity to mainstream smoked-nicotine deliveries on a per-cigarette basis for these cigarette brands were linear (average R2 > 0.91 for nicotine and R2 > 0.83 for the tobacco-specific nitrosamine NNK), on a per-brand basis, with linearity ranging from 0.15 to 3.00 mg nicotine/cigarette. Analysis of spent cigarette filters allows exposures to be characterized on a per-cigarette basis or a “daily dose” via summing across results from all filter butts collected over a 24 h period. This scanner method has a 100-fold lower initial capital cost for equipment than the LC/MS/MS solanesol method and provides high-throughput results (~200 samples per day). Thus, this new method is useful for characterizing exposure related to filtered tobacco-product use.
Prediction and Analysis of Tourist Management Strategy Based on the SEIR Model during the COVID-19 Period
Authors: Shi Yongdong , Huang Rongsheng , Cui Hanwen
Published: October 2021

Tourism destinations are now facing a dilemma choice of controlling the epidemic or developing the economy. This paper takes Macao, a typical international tourist city, as an example to study the strategy of tourist source control during the COVID-19 period. According to the published epidemic data of Macao, this study has established an improved SEIR (Susceptible-Exposed-Infected-Recovered) model, formulated six control strategies against the current epidemic, and used the model above to simulate the time required for all confirmed cases to recover and discharge under different strategies. By taking into consideration the gross revenue of Macao’s gambling industry from 2017 to 2019, the impact of different strategies on the economy is predicted and three control strategies are found to be feasible. This study shows that an effective way to break through the above dilemma is to design the tourist management strategy by screening the source of passengers and controlling the upper limit of capacity of destination. These findings provide a scientific basis for tourism destinations in formulating public policies. The improved SEIR model is more consistent with the actual conversion rule of patients in the current COVID-19 epidemic, and it can be applied to further public health related research.
Increased Risk of Neurodegenerative Dementia after Benign Paroxysmal Positional Vertigo
Authors: Kim So Young , Yoo Dae Myoung , Min Chanyang , Choi Hyo Geun
Published: October 2021

The aim of the present study was to estimate the risk of dementia in patients with benign paroxysmal positional vertigo (BPPV), using a population cohort. Data from the Korean National Health Insurance Service-National Sample Cohort for the population ≥60 years of age from 2002 to 2013 were collected. A total of 11,432 individuals with dementia were matched for age, sex, income, region of residence, hypertension, diabetes, and dyslipidemia with 45,728 individuals comprising the control group. The crude (simple) and adjusted odds ratios (ORs) of dementia in BPPV patients were analyzed using non-conditional logistic regression analyses. Subgroup analyses were conducted according to age and sex. A history of BPPV characterized 5.3% (609/11,432) of the dementia group and 2.6% (1,194/45,728) of the control group (p < 0.001). The adjusted OR of dementia for BPPV was 1.14 (95% CI = 1.03–1.26, p = 0.009). In subgroup analyses according to age and sex, males had higher ORs of dementia for BPPV. BPPV increases the risk of dementia in the 60 years of age or older population.
Transgenerational Trauma and Mental Health Needs among Armenian Genocide Descendants
Authors: Der Sarkissian Alissa , Sharkey Jill D.
Published: October 2021

The trauma of a genocide can be transmitted to subsequent generations though familial mental health, sociopolitical trauma, and cultural narratives, thereby impacting mental health and well-being. Understanding specific mechanisms that are unique to each ethnic group impacted by genocide illuminates cultural, sociopolitical, and individual factors related to the transmission. For the Armenian community, the unresolved historical loss of the Armenian Genocide of 1915, with the threat of acculturation for such a large diasporic population, a continued denial by the perpetrators, as well as subsequent generations’ refugee experiences, may further exasperate the impact of transgenerational trauma from the genocide. This literature review explores the mental health needs of Armenian youth in the current sociopolitical context and provides implications for how schools and communities may use this knowledge to inform supports that center Armenian community healing. Future directions for research are also discussed.
Prevalence and Impact of the Relative Age Effect on Competition Performance in Swimming: A Systematic Review
Authors: Lorenzo-Calvo Jorge , de la Rubia Alfonso , Mon-López Daniel , Hontoria-Galán Monica , Marquina Moises , Veiga Santiago
Published: October 2021

This systematic review aimed to examine the prevalence of the relative age effect (RAE) in swimming and its impact on competition performance according to different types of interacting constraints. A systematic literature search, following the PRISMA guidelines for preparing systematic reviews, was performed through four electronic databases, and nine studies met the inclusion criteria. The quality of the selected studies was evaluated using STROBE, and an average score of 16.2 points was obtained. In these studies, the prevalence of the RAE in swimming was observed in more than half (58.65%) of the participants analysed, and the effect of the RAE was more accentuated in young categories (decreased as age increased and was inverted in older ones) and in male swimmers (double that in female swimmers).The impact of the RAE on competitive performance appeared to be related to the strength demands of the event, as the performance in simultaneous strokes, in shorter events, and of swimmers in the postadolescence period seems to be more affected by the RAE. These results indicate that the RAE in competitive swimming relies on individual and environmental (the swimmer’s age group and gender) but also task (the competitive events) determinants or limitations. This should serve as a guide for a more effective design of selection and development procedures for young athletes.
Melanin: Production from Cheese Bacteria, Chemical Characterization, and Biological Activities
Authors: Ferraz Ana Rita , Pacheco Rita , Vaz Pedro D. , Pintado Cristina S. , Ascensão Lia , Serralheiro Maria Luisa
Published: October 2021

Pigments are compounds of importance to several industries, for instance, the food industry, where they can be used as additives, color intensifiers, and antioxidants. As the current trend around the world is shifting to the use of eco-friendly commodities, demand for natural dyes is increasing. Melanins are pigments that are produced by several microorganisms. Pseudomonas putida ESACB 191, isolated from goat cheese rind, was described as a brown pigment producer. This strain produces a brown pigment via the synthetic Müeller-Hinton Broth. This brown compound was extracted, purified, analyzed by FTIR and mass spectrometry, and identified as eumelanin. The maximum productivity was 1.57 mg/L/h. The bioactivity of eumelanin was evaluated as the capacity for scavenging free radicals (antioxidant activity), EC50 74.0 ± 0.2 μg/mL, and as an acetylcholinesterase inhibitor, with IC50 575 ± 4 μg/mL. This bacterial eumelanin did not show cytotoxicity towards A375, HeLa Kyoto, HepG2, or Caco2 cell lines. The effect of melanin on cholesterol absorption and drug interaction was evaluated in order to understand the interaction of melanin present in the cheese rind when ingested by consumers. However, it had no effect either on cholesterol absorption through an intestinal simulated barrier formed by the Caco2 cell line or with the drug ezetimibe.
Spatiotemporal Evolution of Ecosystem Health of China’s Provinces Based on SDGs
Authors: Zhao Run , Shao Chaofeng , He Rong
Published: October 2021

In the context of increasing ecological scarcity, maintaining the balance between natural and artificial capital has become a popular research topic in the field of ecosystem health. From the perspective of coordinating natural and artificial capital and maintaining the balance between human systems and the Earth’s ecosystem, the Ecosystem Health Index (EHI) was developed on the basis of the Sustainable Development Goals (SDGs). The EHI consists of the Social Progress Index (SPI), Economic Development Index (EDI), Natural Environment Index (NEI), and a pressure adjustment coefficient. Comprehensive indicator assessment models were used to analyze the spatial and temporal evolution of the EHIs in 30 of China’s provinces from 2013 to 2019. A three-dimensional judgment matrix was used to classify the 30 provinces into four basic types. The results show the following: (1) From 2013 to 2019, the EHIs of all provinces improved to different degrees, with 19 provinces achieving a healthy state. (2) Spatially, the EHI showed some regional aggregation in 2013. Provinces with high EHIs were concentrated in the west, followed by those in the east, and those in the central provinces had the lowest EHIs. However, the differences between regions had narrowed by 2019. (3) The spatial distribution patterns of the NEI and the EDI varied widely, and most provinces did not reach a high level of coordination between natural and artificial capital. (4) The environmental pressure in all provinces, except Liaoning, decreased over time. In some cases, excessive pressure decreased the pressure-adjusted EHI, regardless of the EHI value. (5) According to the results of the ecosystem health classification in each province, the factors that hinder ecosystem health vary from place to place.
Mental Health and Work-Related Behaviors in Management of Work Requirements of University Lecturers in Ukraine—An Age Group Comparison
Authors: Thielmann Beatrice , Karlsen Håvard Rudi , Tymbota Myroslav , Kapustnyk Valeriy , Zavgorodnia Nathalie , Zavgorodnii Igor , Böckelmann Irina
Published: October 2021

Background: There are only a few national and international studies on the health of third-level professor lecturers at universities and colleges. Work-related diseases are important and relevant for occupational medicine. The aim of the study was to examine the mental health and work-related behavior and experience patterns of Ukrainian university lecturers in age group comparisons. Methods: Data were collected from 81 Ukrainian university lecturers (General Health Questionnaire (GHQ-12), Questionnaire on Work-Related Behavior and Experience Patterns (AVEM)). The university lecturers were split into 4 age groups. Results: 9.9% of higher education lecturers reported impaired mental health (GHQ-12). In all, 64.8% of the total sample showed AVEM risk patterns. There were differences in age groups (third age group scoring lower than the first age group on the GHQ total score). The first age group had significantly lower opinions of the subjective importance of work on their personal lives compared to the third and fourth age group, while the second age group had significantly lower opinions compared to the fourth age group. All individuals with impaired mental health in GHQ-12 had AVEM risk patterns. Conclusions: These results offer novel insights into the health of Ukrainian university lecturers. Occupational healthcare practitioners should take them into consideration in order to initiate appropriate interventions.
Prevalence of Second Victims, Risk Factors, and Support Strategies among German Nurses (SeViD-II Survey)
Authors: Strametz Reinhard , Fendel Johannes C. , Koch Peter , Roesner Hannah , Zilezinski Max , Bushuven Stefan , Raspe Matthias
Published: October 2021

Background: Second victim phenomena (SVP) are critical to workplace and patient safety, and epidemiological data are limited to investigate the causes and impact on German health care. We investigated SVP in German nurses regarding prevalence, causes, and predisposition compared to a preceding study on German physicians (Second Victims in Deutschland/SeViD-I). Methods: We conducted a nationwide anonymous cross-sectional online study in 2020 using a modified SeViD questionnaire including the BFI-10 (personality traits). Statistical analysis was conducted using chi² tests and binary logistic regression models. Results: Of 332 nurses, 60% reported to experience SVP at least once a working lifetime, with a 12-month prevalence among SVP of 49%. Of the nurses, 24% reported recovery times of more than 1 year. In contrast to physicians from SeViD-I, a main cause for becoming a second victim was aggressive behavior by patients. High neuroticism values, higher age, and medium work life experience, but neither gender nor workplace position, were predisposing for SVP. Like SeViD-I, nurses reported demand for an institutional response in cases of SVP. Conclusions: SVP is common among German nurses and comprises other causes and a different course than in physicians. Further research should concentrate on specific prevention strategies, e.g., profession- and workplace-based educational programs.
Core Temperature Measurement—Principles of Correct Measurement, Problems, and Complications
Authors: Hymczak Hubert , Gołąb Aleksandra , Mendrala Konrad , Plicner Dariusz , Darocha Tomasz , Podsiadło Paweł , Hudziak Damian , Gocoł Radosław , Kosiński Sylweriusz
Published: October 2021

Core temperature reflects the temperature of the internal organs. Proper temperature measurement is essential to diagnose and treat temperature impairment in patients. However, an accurate approach has yet to be established. Depending on the method used, the obtained values may vary and differ from the actual core temperature. There is an ongoing debate regarding the most appropriate anatomical site for core temperature measurement. Although the measurement of body core temperature through a pulmonary artery catheter is commonly cited as the gold standard, the esophageal temperature measurement appears to be a reasonable and functional alternative in the clinical setting. This article provides an integrative review of invasive and noninvasive body temperature measurements and their relations to core temperature.
The Direct and Spillover Effect of Multi-Dimensional Urbanization on PM2.5 Concentrations: A Case Study from the Chengdu-Chongqing Urban Agglomeration in China
Authors: Wang Sicheng , Sun Pingjun , Sun Feng , Jiang Shengnan , Zhang Zhaomin , Wei Guoen
Published: October 2021

The Chengdu-Chongqing urban agglomeration (CUA) faces considerable air quality concerns, although the situation has improved in the past 15 years. The driving effects of population, land and economic urbanization on PM2.5 concentrations in the CUA have largely been overlooked in previous studies. The contributions of natural and socio-economic factors to PM2.5 concentrations have been ignored and the spillover effects of multi-dimensional urbanization on PM2.5 concentrations have been underestimated. This study explores the spatial dependence and trend evolution of PM2.5 concentrations in the CUA at the grid and county level, analyzing the direct and spillover effects of multi-dimensional urbanization on PM2.5 concentrations. The results show that the mean PM2.5 concentrations in CUA dropped to 48.05 μg/m3 at an average annual rate of 4.6% from 2000 to 2015; however, in 2015, there were still 91% of areas exposed to pollution risk (>35 μg/m3). The PM2.5 concentrations in 92.98% of the area have slowly decreased but are rising in some areas, such as Shimian County, Xuyong County and Gulin County. The PM2.5 concentrations in this region presented a spatial dependence pattern of “cold spots in the east and hot spots in the west”. Urbanization was not the only factor contributing to PM2.5 concentrations. Commercial trade, building development and atmospheric pressure were found to have significant contributions. The spillover effect of multi-dimensional urbanization was found to be generally stronger than the direct effects and the positive impact of land urbanization on PM2.5 concentrations was stronger than population and economic urbanization. The findings provide support for urban agglomerations such as CUA that are still being cultivated to carry out cross-city joint control strategies of PM2.5 concentrations, also proving that PM2.5 pollution control should not only focus on urban socio-economic development strategies but should be an integration of work optimization in various areas such as population agglomeration, land expansion, economic construction, natural adaptation and socio-economic adjustment.
Reflections Based on Pollution Changes Brought by COVID-19 Lockdown in Shanghai
Authors: Zhang Fang , Han Yi , Cong Bailin
Published: October 2021

COVID-19 and its variants have been changing the world. The spread of variants brings severe effects to the global economy and to human’s lives and health, as well as to society. Lockdown is proven to be effective in stopping the spread. It also provides a chance to study natural environmental changes with humanity’s limited interference. This paper aims to evaluate the impact of lockdown on five major airborne pollutants, i.e., NO2, SO2, O3, PM2.5 and PM10, in the three different functional regions of Chongming, Xuhui and Jinshan of Shanghai. Changes in the same pollutants from the three regions over the same/different periods were all studied and compared. Overall, the COVID-19 lockdown has changed pollutant concentrations in the long and short terms. Concentrations of four pollutants decreased, except for that of earth surface O3, which increased. SO2 had significant correlations with all other pollutants. PM2.5 and PM10 are more externally input than locally produced. NO2, SO2 and PM levels sharply reduced in Jinshan and Xuhui due to the limited usage of fossil fuel. Lockdown improved the air quality. People now have a chance to rethink the value of life and the harmony between economic progress and environmental protection. This is helpful to establish sustainable societies.
Impact of Life Stressors on Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Symptoms: An Australian Longitudinal Study
Authors: Balinas Cassandra , Eaton-Fitch Natalie , Maksoud Rebekah , Staines Donald , Marshall-Gradisnik Sonya
Published: October 2021

(1) Background: Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a complex, multifaceted illness. The pathomechanism, severity and progression of this illness is still being investigated. Stressors have been implicated in symptom exacerbation for ME/CFS, however, there is limited information for an Australian ME/CFS cohort. The aim of this study was to assess the potential effect of life stressors including changes in work, income, or family scenario on symptom severity in an Australian ME/CFS cohort over five months; (2) Methods: Australian residents with ME/CFS responded to questions relating to work, income, living arrangement, access to healthcare and support services as well as symptoms experienced; (3) Results: thirty-six ME/CFS patients (age: 41.25 ± 12.14) completed all questionnaires (response rate 83.7%). Muscle pain and weakness, orthostatic intolerance and intolerance to extreme temperatures were experienced and fluctuated over time. Sleep disturbances were likely to present as severe. Work and household income were associated with worsened cognitive, gastrointestinal, body pain and sleep symptoms. Increased access to healthcare services was associated with improved symptom presentation; (4) Conclusions: life stressors such as work and financial disruptions may significantly contribute to exacerbation of ME/CFS symptoms. Access to support services correlates with lower symptom scores.
A Social-Ecological Approach to Understanding the Relationship between Cyberbullying Victimization and Suicidal Ideation in South Korean Adolescents: The Moderating Effect of School Connectedness
Authors: Lee Jungup , Chun JongSerl , Kim Jinyung , Lee Jieun , Lee Serim
Published: October 2021

Background: Cyberbullying victimization and suicidal ideation are both ongoing deleterious social problems in South Korea. Using the social-ecological approach, this study examined the association between cyberbullying victimization and suicidal ideation as well as the buffering role of school connectedness in this relationship. Methods: A nationally representative sample of 7333 adolescents from the 2016 Korean Children and Youth Right Study participated in the study. Data were analyzed using descriptive statistics, Wald chi-square test, bivariate correlations, and multivariate logistic regression analyses. Results: Nearly 17.7% of adolescents were cyberbullied, and 28.4% had suicidal ideation in the past 12 months. Cyberbullying victims were at an increased risk of suicidal ideation. The results also found that parental abuse, family dysfunction, and perceived peer relationship stress were positively associated with suicidal ideation, while parental support for autonomy was negatively associated with suicidal ideation. Further, school connectedness moderated on the relationship between cyberbullying victimization and adolescent suicidal ideation. Conclusions: These findings suggest that various stakeholders should consider interventions and preventive programs that address school connectedness when working with adolescents who are victims of cyberbullying and exhibit suicidal behavior.
Effects of Intermittent and Continuous Static Stretching on Range of Motion and Musculotendinous Viscoelastic Properties Based on a Duration-Matched Protocol
Authors: Oba Kensuke , Samukawa Mina , Abe Yosuke , Suzuki Yukino , Komatsuzaki Miho , Kasahara Satoshi , Ishida Tomoya , Tohyama Harukazu
Published: October 2021

The different effects of intermittent and continuous stretching on the mechanical properties of the musculotendinous complex have been unclear. This study aimed to compare the effects of intermittent and continuous stretching for the same duration on the range of motion (ROM), passive resistive torque (PRT), and musculotendinous stiffness (MTS) of ankle plantar flexors. Eighteen healthy young men participated in the study. Intermittent (four sets × 30 s) and continuous stretching (one set × 120 s) were performed in random orders on two separate days. Both stretching protocols were conducted using a dynamometer with a constant torque applied. ROM and PRT were determined using a dynamometer, and MTS was calculated using the torque–angle relationship measured before and after stretching. Two-way repeated measures analysis of variance was performed for all parameters. Both intermittent and continuous stretching significantly increased ROM and decreased PRT and MTS (p < 0.05). Intermittent stretching led to greater changes in ROM and PRT than continuous stretching. However, the reduction in MTS did not differ between the two conditions. These results suggest that intermittent stretching is more effective in increasing ROM and changing the mechanical properties of the musculotendinous complex.
Socio-Economic Disparities in Access to Diagnostic Neuroimaging Services in the United Kingdom: A Systematic Review
Authors: Karia Aleesha , Zamani Reza , Akrami Mohammad
Published: October 2021

Socio-economic factors affecting health care can lead to delays in diagnosis of neurological conditions, consequentially affecting treatment and morbidity rates. This inequality in health care can leave patients from lower socio-economic backgrounds more vulnerable to a poorer quality of care from health care providers in the United Kingdom (U.K.). Aims: In this systematic review, we assess the impact of socio-economic status on the use of diagnostic neuroimaging in the U.K., measured by the timeliness, accessibility and appropriate use of computed tomography (CT), magnetic resonance imaging (MRI), ultrasonography, electroencephalography (EEG) and single-photon emission computed tomography (SPECT). We specifically evaluate the non-surgical use of neuroimaging techniques as this relies on the judgment of primary care-givers (e.g., doctors and radiologists), where health disparities are most common. This study includes the analysis of diagnostic imaging used for dementia, minor head injury, stroke, cancer, epilepsy, chronic inflammatory demyelinating polyneuropathy and Parkinson’s disease. With this study, we aim to assess the health inequalities at disease diagnosis. Methods: Using Medline (via Ovid), PubMed and Web of Science databases as sources of information, we critically appraise existing studies on neuroimaging use in the U.K. health care system, published between January 2010 and February 2021. Findings: A total of 18 studies were included in this research, revealing that there was an increase in patients of Black and Asian communities diagnosed with dementia and at an earlier age. There was little evidence to suggest that a lack of access to diagnostic imaging is associated with socio-economic status. However, there are data to suggest that people of a lower socio-economic background require more specialist services with diagnostic neuroimaging tools. In addition, there is evidence to suggest that diagnostic neuroimaging techniques could be utilised more effectively by health care workers to prevent unnecessary delays in diagnosis for patients in lower socio-economic areas.
Rule of Law, Corruption Control, Governance, and Economic Growth in Managing Renewable and Nonrenewable Energy Consumption in South Asia
Authors: Mahmood Haider , Tanveer Muhammad , Furqan Maham
Published: October 2021

Strong governance is vital for developing environmental policies to promote renewable energy consumption and discourage nonrenewable energy sources. The present research explores the effect of economic growth and different governance indicators on renewable and nonrenewable energy consumption in Pakistan, India, Bangladesh, and Sri Lanka using data from 1996 to 2019. For this purpose, the study uses different econometric techniques to find the long-term effects of the rule of law, regulatory quality, corruption control, government effectiveness, political stability, voice and accountability, and economic growth on oil, natural gas, coal, hydroelectricity, and renewable energy consumption. The results show that economic growth has a positive impact on all investigated renewable and nonrenewable energy sources. Additionally, regulatory quality measures also increase all types of renewable and nonrenewable energy consumption. Except for natural gas, the impact of the rule of law is negative, and government effectiveness positively affects all energy sources. Control of corruption has a positive effect on natural gas consumption. Political stability has a negative effect on nonrenewable energy sources and a positive impact on renewable energy sources. The magnitudes of the effects of economic growth and most governance indicators are found to be larger on nonrenewable sources than renewable sources. The testing of the energy consumption and governance nexus is scant in global literature and is missing in South Asian literature. Hence, the study results contribute to how South Asian economies can be more sustainable in energy use by enhancing governance indicators in the economies. Particularly, the results imply that these countries should focus on improving the rule of law, corruption control, governance, regulatory quality, political stability, and economic growth to help maintain a sustainable balance of renewable and nonrenewable energy sources. Moreover, this issue needs further attention in developing countries, as governance indicators would play an effective role in promoting sustainable energy.
Changes in Stress-Mediated Markers in a Human Cardiomyocyte Cell Line under Hyperglycemia
Authors: Thakur Vikram , Alcoreza Narah , Cazares Jasmine , Chattopadhyay Munmun
Published: October 2021

Diabetes is a major risk factor for cardiovascular diseases, especially cardiomyopathy, a condition in which the smooth muscles of the heart become thick and rigid, affecting the functioning of cardiomyocytes, the contractile cells of the heart. Uncontrolled elevated glucose levels over time can result in oxidative stress, which could lead to inflammation and altered epigenetic mechanisms. In the current study, we investigated whether hyperglycemia can modify cardiac function by directly affecting these changes in cardiomyocytes. To evaluate the adverse effect of high glucose, we measured the levels of gap junction protein, connexin 43, which is responsible for modulating cardiac electric activities and Troponin I, a part of the troponin complex in the heart muscles, commonly used as cardiac markers of ischemic heart disease. AC16 human cardiomyocyte cells were used in this study. Under hyperglycemic conditions, these cells demonstrated altered levels of connexin 43 and Troponin-I after 24 h of exposure. We also examined hyperglycemia induced changes in epigenetic markers: H3K9me1, Sirtuin-1 (SIRT1), and histone deacetylase (HDAC)-2 as well as in inflammatory and stress-related mediators, such as heat shock protein (HSP)-60, receptor for advanced glycation end products (RAGE), toll-like receptor (TLR)-4, high mobility group box (HMGB)-1 and CXC chemokine receptor (CXCR)-4. Cardiomyocytes exposed to 25mM glucose resulted in the downregulation of HSP60 and SIRT1 after 48 h. We further examined that hyperglycemia mediated the decrease in the gap junction protein CX43, as well as CXC chemokine receptor CXCR4 which may affect the physiological functions of the cardiomyocytes when exposed to high glucose for 24 and 48 h. Upregulated expression of DNA-binding nuclear protein HMGB1, along with changes in histone methylation marker H3K9me1 have demonstrated hyperglycemia-induced damage to cardiomyocyte at 24 h of exposure. Our study established that 24 to 48 h of hyperglycemic exposure could stimulate stress-mediated inflammatory mediators in cardiomyocytes in vitro. These stress-related changes in hyperglycemia-induced cardiomyocytes may further initiate an increase in injury markers which eventually could alter the epigenetic processes. Therefore, epigenetic and inflammatory mechanisms in conjunction with alterations in a downstream signaling pathway could have a direct effect on the functionality of the cardiomyocytes exposed to high glucose during short and long-term exposures.