bluuebunny/crossref_metadata_2025 huggingface dataset:
Optimalisasi Produksi Kue Kering Yayasan Amal Mulia Indonesia Menggunakan Program Linier Metode Substitusi
Authors: Latifah Siti , Akbar Gustomi , Nur Ribkhah Sifa
Published: March 2023

One of the basic things that can be done to anticipate the negative impact of rising prices of production materials is to re-analyze the prices of production materials with the selling prices of production using a linear program. In this study, the analysis technique used was linear programming using the substitution method to obtain profit predictions from selling Cookies. The purpose of this study is to determine the optimization of pastries production to generate maximum profit. The case study was conducted in the Pastry Business at the Mulia Amal Foundation, South Jakarta, Indonesia. The results of the research on optimizing the production of the KUKERAMI pastry business Yayasan Amal Mulia Indonesia produces with optimal results, the profit earned on last year's sales using the linear program substitution method achieved a profit of IDR 6,900,000 by selling chocolate cookies and snow white cookies, 70 jars each and 60 jars.
Sistem Informasi Persuratan Berbasis Website Studi Kasus di SMAN 1 Dramaga
Authors: Septian Ihsan , Jaenudin Jejen , Eosina Puspa
Published: March 2023

Letters are an important means of communication in every institution, including at SMAN 1 Dramaga. Unfortunately, letter management at the school is still done manually. Therefore, a web-based letter management information system was designed to help manage and process letter data efficiently and organized. The letter information system can accelerate the letter management process and avoid damage to letters that are stored for too long. A Letter Information System is required to improve letter management performance with timely letter issuance. The system development method used is the SDLC (System Development Life Cycle) method. Data collection methods include observation, interviews, and heritage studies. With a web-based information system, it can improve and facilitate letter management performance, timely letter issuance, and avoid damage to letters that are stored for too long. The result makes it easy to store letters centrally in a database that can be accessed again.
Forecasting Omset Printing of Printing Sales in CV Sembilan Jaya with Neural Network Method
Authors: Mawarti Reni Vivit Ayu , Herulambang Wiwiet , Adityo R Dimas
Published: March 2023

Forecasting is a process for estimating several needs in the future which includes needs in order to meet thedemand for goods and services. Neural Network Backpropagation Method is a time series forecasting method. Thepurpose of this study is to predict the turnover results in the next period obtained by CV. Nine Jaya every week. Thisstudy uses sales data obtained from the printing of food boxes, shoe boxes, watch boxes from January 2014 toDecember 2018. The results of this forecasting are done using the Neural Network method, the smallest MSE valueobtained is 0.004211 with 1000 times iteration and learning rate 0.2. The MSE value obtained meets the condition orcondition value as a good forecasting method because it is able to meet the MSE value requirement <0.1.
Decision Support System for The Feasibility of Giving Customer Credit Using Topsis and Saw Methods (case Study): Save Loan Cooperative CV. the Source of Prosperous Life
Authors: Hidayat M Mahaputra , Hamidah Mas Nurul , Nur Ayu
Published: March 2023

Supporting System for Deciding the Feasibility of Providing Credit to Customers with Topsis Method andSimple Additive Weighting Method in CV. Sumber Hidup Prosperous, this research is motivated by the results of acustomer who must meet the criteria determined by the cooperative to be able to get credit. In this case cooperativesare required to be able to make decisions quickly and carefully. To realize this it is necessary to have a decisionsupport system (SPK) with the Topsis method and the Simple Additive Weighting method that can solve the problemof decision making with many criteria. The results obtained from this study are the application program of the DecisionSupport System for Providing Credit to the Customer with the Topsis Method and the Simple Additive WeightingMethod in CV. The Source of Prosperous Life. The conclusions of the results of this study have shown a value that isaccurate enough to help simplify the process of creditworthiness and report generation.
Valorización de los residuos de podas de Jatropha curcas L para la obtención de pulpa celulósica
Authors: Martinez Valencia Biaani Beeu , Ocaña Colmenares Luz Dariana , Solis Bonilla José Luis , Lucas Rojas Sofia , Velázquez Pérez Diana Yoheli
Published: March 2023

En los últimos años, se han realizado trabajos de investigación sobre el uso de residuos agrícolas para la producción de materiales verdes mediante métodos químicos, estos recursos renovables y disponibles deben combinarse con tecnologías avanzadas. El presente trabajo se enfocó en desarrollar un proceso para la obtención de pulpa celulósica derivado de residuos de podas de Jatropha curcas L., con el fin de crear nuevas alternativas para la elaboración de papel.
Producción de aguacate en Tetela del Volcán: identificación de beneficios para los productores.
Authors: Almeraya-Quintero Silvia X. , Guajardo-Hernández Lenin G. , Pérez-Hernández Luz M. , Borja-Bravo Mercedes
Published: March 2023

Determinar los costos de producción agrícola brinda certidumbre sobre la rentabilidad del cultivo
Desarrollo de capacidades de Productores participantes en los Mercados Agro Mexiquenses
Authors: Pérez-Hernández Luz María , Almeraya-Quintero Silvia X. , Ayala-Carrillo María del R. , Guajardo-Hernández Lenin G.
Published: March 2023

Los productores rurales en pequeña escala, enfrentan entre muchas limitantes la comercialización de sus productos de forma individual
Reef Islands of Sabah, Malaysia
Authors: Adnan Farrah A.F. , Hamylton Sarah M. , Woodroffe Colin D.
Published: March 2023

Numerous low-lying, unconsolidated carbonate reef islands occur on the shallow reefs of the South China, Sulu and Celebes Seas off the coast of Sabah, at the northeastern end of Borneo. A range of sources, including maps and charts, as well as freely available satellite imagery, has been used to map the location of these islands, identify them, and develop a classification. A total of 44 reef islands were differentiated into: a) sandy areas visible on top of shallow reef flats, b) islands of low elevation, and c) islands of small area (many less than 1 ha). These reef islands were classified based on a) the presence of vegetation and density of vegetation cover, and b) the degree and identification of infrastructure development and human disturbance on the islands. Of the 26 identified in the Sulu Sea, 11 are unvegetated sand cays, 10 have sparse vegetation, and 5 are densely vegetated. Of the 16 reef islands in the Celebes Sea, 8 are sparsely vegetated, and 6 are densely vegetated. In the South China Sea, the densely vegetated Kalampunian Besar Island in the Pulau Tiga Park is contrasted with the extensive infrastructure of Pulau Layang-Layang Atoll. Many undeveloped islands occur in the Sulu Sea, while the three most developed islands occur in the Celebes Sea. Some islands, such as Mabul Island, are predominantly covered with buildings with construction extending over the reef flat. Several islands have been designated as Marine Protected Areas due to the significance of their biota. This inventory provides a baseline of the characteristics of these islands at the time of image acquisition to provide a much-needed record of their current status and against which future changes can be assessed.
Traditional Chinese medicine in treating Corona Virus Disease 2019: a systematic review and cost-effectiveness analysis
Authors: Shao Taihang , Wang Ke , Liao Xing , Tang Wenxi
Published: March 2023

ABSTRACT

Background: Currently, corona virus disease 2019 (COVID-19) has infected 633,601,048 people worldwide according to World Health Organization, which leads to huge disease burden. A considerable number of trials of traditional Chinese medicine (TCM) have been carried out and have shown the efficacy of TCM in the treatment of COVID-19, but their cost-effectiveness has not been studied, especially in China. Therefore, we plan to perform a systematic review and cost-effectiveness analysis to explore the cost-effectiveness of using TCM in treating COVID-19.

Methods: A systematic review based on previously published secondary data from randomized controlled trials and observational studies which included TCM as one of the interventions for patients with COVID-19 will be performed. Patients with COVID-19 will be classified into five specific groups (patients without diagnosis; patients with mild, moderate, severe and critical symptoms). TCM versus western medicine on both effectiveness outcomes(cure rate and survival rate) and utility outcome(quality-adjusted life years) will be evaluated. A decision tree model will be established taking the perspective of Chinese health care system since the costs were paid by the Chinese government. Cumulative costs, Qalys, and incremental cost-effectiveness ratio will be selected as the outcome indicator. Sensitivity analysis will also be conducted to evaluate the impact of parameter uncertainty on the base-case analyses results. We will present results at various willingness-to-pay thresholds using a cost-effectiveness acceptability curve.

Discussion We hope to demonstrate the cost-effectiveness of TCM, see an improvement in the patients' quality of life, achieve a improvement in the cure rate and survival rate of COVID-19. If TCM is cost-effectiveness, it could be applied to clinical practice decision making.

Ethics and dissemination: Ethics approval is not required for the current study. Because the data used in this study is just the re-use of data which are already in the public domain. The results will be disseminated to general public, clinicians, academics and policy makers.

Registration number: CRD42021228887

Keywords: Traditional Chinese medicine; Corona Virus Disease 2019; decision tree model; systematic review; cost-effectiveness analysis
Peran Vitamin D pada Fungsi Sawar Permeabilitas Kulit
Authors: Damayanti Nita
Published: March 2023

Salah satu fungsi utama kulit adalah membentuk sawar antara tubuh dan lingkungan eksternal. Fungsi sawar permeabilitas kulit salah satunya dipertahankan dengan proses diferensiasi dan proliferasi keratinosit pada lapisan epidermis. Efek vitamin D pada kulit termasuk memengaruhi proliferasi, diferensiasi, dan apoptosis keratinosit. Defisiensi serta kelainan aktivasi dan metabolisme vitamin D menyebabkan defek fungsi sawar permeabilitas kulit. Makalah ini membahas epidermis sebagai sawar permeabilitas kulit dan peran vitamin D pada sawar permeabilitas kulit.

One of the skin’s main functions is to form a protective barrier towards external environment. The protective function is maintained by differentiation and proliferation of keratinocytes in the epidermal layer. Vitamin D effects on the skin include proliferation, differentiation, and apoptosis of keratinocyte. Deficiency and abnormalities of vitamin D activation and metabolism impair skin’s function as permeability barrier. This paper discusses the epidermis as permeability barrier and the role of vitamin D in the skin permeability barrier.
Komplikasi Sistem Saraf Pusat pada COVID-19
Authors: Esterita Tasia , Wreksoatmodjo Budi Riyanto
Published: March 2023

Coronavirus disease-19 disebabkan oleh virus SARS-CoV-2 yang menyebabkan pandemi sejak Maret 2020. COVID-19 tidak hanya menyebabkan komplikasi pernapasan dan kardiovaskular, tetapi dapat menyebabkan komplikasi sistem saraf pusat yang juga berkontribusi terhadap mortalitas dan morbiditas. Beberapa komplikasi sistem saraf pusat pada COVID-19 adalah stroke iskemik, stroke hemoragik, meningoensefalitis, acute transverse myelitis, dan ensefalopati. Stroke iskemik pada COVID-19 disebabkan oleh beberapa mekanisme, di antaranya koagulopati, disfungsi endotel, kardioemboli, invasi virus ke sistem saraf pusat, dan terapi imunoglobulin. Stroke hemoragik dapat disebabkan oleh kerusakan endotel akibat inflamasi menyebabkan disregulasi tekanan darah yang meningkatkan risiko stroke hemoragik. Meningoensefalitis pada COVID-19 disebabkan invasi virus langsung melalui cribriform plate atau karena kerusakan endotel yang menjadi pintu masuk SARS-CoV-2 ke otak. Mielitis transversa pada COVID-19 disebabkan hiperinflamasi sistemik, molecular mimicry, dan epitope spreading. Kegagalan organ multipel pada pasien COVID-19 akibat badai sitokin dapat menyebabkan ensefalopati.

Coronavirus disease-19 is caused by the SARS-CoV-2 virus that has been causing a pandemic since March 2020. Besides respiratory and cardiovascular complications, COVID-19 can cause complications to central nervous system that also contribute to mortality and morbidity. Some central nervous system complications in COVID-19 are ischemic stroke, hemorrhagic stroke, meningoencephalitis, acute transverse myelitis, and encephalopathy. Ischemic stroke in COVID-19 is caused by several mechanisms, including coagulopathy, endothelial dysfunction, cardioembolism, viral invasion of the central nervous system and immunoglobulin therapy. Hemorrhagic stroke can be associated with blood pressure dysregulation caused by inflammational endothelial damage. Meningoencephalitis in COVID-19 can be caused by direct viral invasion through the cribriform plate or due to endothelial damage that facilitate SARS-CoV-2 entrance to the brain. Transverse myelitis in COVID-19 is caused by systemic hyperinflammation, molecular mimicry and epitope spreading. Multiple organ failure in COVID-19 patients due to a cytokine storm can lead to encephalopathy.
Osteomielitis: Diagnosis, Tata Laksana Bedah, dan Medikamentosa
Authors: Theola Jason , Suryoadji Kemal Akbar , Yudianto Valentino Ryu
Published: March 2023

Osteomielitis merupakan peradangan tulang dan sumsum tulang yang biasanya disebabkan oleh infeksi bakteri. Osteomielitis dapat menimbulkan gangguan fungsional irreversibel dan disabilitas. Namun, hingga saat ini, belum ada guideline khusus diagnosis dan manajemen tata laksana osteomielitis. Diagnosis dan tata laksana osteomielitis harus komprehensif agar memberikan hasil baik.

Osteomyelitis is an inflammation of bone and bone marrow which is usually caused by bacterial infection. Osteomyelitis can cause irreversible functional problems and disabilities. There is still no specific guidelines for diagnosis and management of osteomyelitis. Diagnosis and management must be conducted comprehensively to result in good recovery.
STEMI Inferior dengan Infark Ventrikel Kanan dan Posterior
Authors: Kurnia Andy
Published: March 2023

Infark miokard dengan elevasi segmen ST atau ST elevation myocardial infarction (STEMI) inferior merupakan salah satu jenis sindrom koroner akut (SKA) dengan prognosis dan luaran cukup baik. Namun, bila didapatkan infark ventrikel kanan dan posterior, prognosis dan luaran akan menjadi lebih buruk. Oleh karena itu, gambaran EKG STEMI inferior dengan keterlibatan infark ventrikel kanan dan posterior perlu dikenali guna tata laksana yang tepat dan akurat.

Inferior ST elevation myocardial infarction is a subset of acute coronary syndrome (ACS) with better prognosis and outcome. However, if right ventricular (RV) and posterior infarction are involved, the prognosis and outcome may be worse. Recognizing the ECG pattern of inferior wall myocardial infarction with RV and posterior involvement is important to provide precise and accurate management.
Coenzyme Q10 and/or Vitamin E Supplementation for Polycystic Ovarian Syndrome
Authors: Irianto Christian Bobby , Prasetyadi Erick Giovanni
Published: March 2023

Excessive androgens, insulin resistance, and changing estrogen levels in polycystic ovarian syndrome (PCOS) could affect the metabolic markers and lead to the increment of oxidative stress level. Coenzyme Q10 (CoQ10) is an organic molecule ubiquitously present in cell membranes and mitochondria. It is known to inhibit the peroxidation of cell membrane lipids and reduce the oxidation of circulating lipids, decreasing oxidative stress-induced cell damage. Vitamin E, an exogenous lipid-soluble molecule with antioxidant property, is a direct free radical scavenger that protects the cell membrane from lipid peroxidation and activates intracellular antioxidant enzymes. Some studies suggest that the cosupplementation of CoQ10 and vitamin E has strong synergistic outcomes in women with PCOS. The combination of those antioxidant agents is more likely to have better reproductive and metabolic outcomes.

Kadar androgen berlebih, resistensi insulin, dan perubahan kadar estrogen pada sindrom ovarium polikistik (SOPK) dapat memengaruhi parameter metabolik dan meningkatkan kadar stres oksidatif. Koenzim Q10 (CoQ10) merupakan molekul organik yang banyak ditemukan di dalam membran sel dan mitokondria. Molekul tersebut diketahui dapat menghambat proses peroksidasi lipid membran sel dan mengurangi proses oksidasi lipid dalam sirkulasi, sehingga berdampak mengurangi kerusakan sel yang disebabkan oleh reaksi stres oksidatif. Vitamin E yang merupakan molekul eksogen larut lemak berperan melindungi membran sel dari proses peroksidasi lipid dan membantu aktivasi enzim antioksidan intraseluler. Beberapa penelitian menunjukkan bahwa ko-suplementasi CoQ10 dan vitamin E memberikan dampak signifikan pada wanita dengan SOPK. Kombinasi dua antioksidan tersebut memberikan efek lebih baik dibandingkan pemberian terpisah.
Penggunaan Steroid Sistemik pada Henoch Schonlein Purpura
Authors: Masyalia Hasna Taqiyyah
Published: March 2023

Steroid umum digunakan pada HSP mengingat efek antiinflamasinya. Namun, di lain pihak beberapa kasus HSP dapat sembuh sendiri hanya dengan terapi simtomatik ataupun suportif. Penelitian terkini menunjukkan bahwa steroid hanya bermanfaat pada beberapa kasus HSP. Penggunaan steroid harus dipertimbangkan berdasarkan indikasi dan tidak untuk setiap kasus HSP.

Steroids are commonly used in all cases of HSP because of its anti-inflammatory effect. However, some HSP cases are self-limiting and only necessitate symptomatic or supportive therapy. Recent research has shown that steroids are beneficial in only a few cases of HSP. Steroid should be used as indicated and considered in every case of HSP.
Peutz-Jeghers Syndrome
Authors: Mahendra Cipta
Published: March 2023

Sindrom Peutz-Jeghers (Peutz-Jeghers Syndrome/PJS) merupakan penyakit herediter langka dengan ciri klinis pigmentasi mukokutaneus dan polip gastrointestinal. Hingga kini, satu-satunya upaya terapi adalah eliminasi polip melalui metode endoskopi dan/atau operasi laparatomi abdomen invasif. Penderita PJS memiliki risiko tinggi mendapat berbagai jenis kanker, sehingga diperlukan skrining rutin. Para penderita PJS perlu mendapat edukasi dan dukungan mental. Diperlukan riset lebih mendalam untuk tatalaksana terbaik sindrom PJS.

Peutz-Jeghers Syndrome (PJS) is rare hereditary disease with mucocutaneous pigmentations and gastrointestinal polyps as the most prominent clinical features. The only approved treatment is to eliminate the polyps by endoscopy and/or invasive abdominal laparotomy surgery. Patients with PJS have a high lifetime risk of various cancers and warrants regular surveillance for early signs of malignancies. PJS patients need to be well-informed and supported by the treating physicians to cope with their PJS status. More research in the management of PJS is needed
Pengaruh Pemberian Plasma Konvalesen terhadap Lama Rawat Inap Pasien COVID-19
Authors: Hermanadi Muhammad Ikrar , Theola Jason , Suryoadji Kemal Akbar , Nurfateen Ashadi Dhiya Athaullah
Published: March 2023

Masih meningkatnya kasus positif dan kematian COVID-19 di Indonesia menuntut fasyankes agar bisa mempersingkat durasi hospitalisasi/ rawat inap untuk efisiensi sumber daya kesehatan dan peningkatan kualitas pelayanan. Terapi adjuvan pasien rawat inap antara lain terapi plasma konvalesen (TPK). Review ini bertujuan untuk mengetahui pengaruh pemberian TPK dan terapi standar dibandingkan terapi standar saja terhadap durasi rawat inap pasien COVID-19. Penelusuran artikel secara manual pada empat database, yaitu PubMed, Cochrane, ScienceDirect, dan Scopus. Kata kunci yang digunakan adalah convalescent plasma, COVID-19 therapy, COVID-19 serotherapy, length of stay. Metode seleksi berdasarkan kriteria eligibilitas mendapatkan 1 artikel yang kemudian ditelaah kritis dari segi kesahihan, kepentingan, dan kemamputerapan. Satu artikel tinjauan sistematis merupakan artikel yang sahih dan penting, tetapi kurang memiliki kemamputerapan karena demografi dan kondisi klinis yang tidak sesuai. Review ini menyimpulkan bahwa pemberian TPK tidak memengaruhi durasi rawat inap pasien COVID-19. Diperlukan studi lebih lanjut dengan demografi dan kondisi klinis yang sesuai untuk mendapat keyakinan tertinggi.

Indonesia is still in an ongoing trend of positive cases and deaths caused by COVID-19. This condition urges health care facilities to reduce length of stay for more efficient health resources management and higher quality of care. Adjuvant therapy to hospitalized patients includes convalesent plasma therapy (CPT). This review aims to determine the effect of CPT on length of stay of COVID-19 patients in comparison to standard therapy. Literature search is through hand searching and through four databases: PubMed, Cochrane, ScienceDirect, and Scopus. Keywords used are: convalescent plasma, COVID-19 therapy, COVID-19 serotherapy, length of stay. Selection through eligibility criteria resulted in one systematic review article, then critically appraised by its’ validity, importance, and applicability.The article selected is valid and important, yet lack of applicability due to discrepancy in demographics and clinical conditions. The review concluded that CPT does not affect the length of stay of COVID-19 patients.More research with similiar demographics and clinical conditions are needed to achieve highest level of certainty.
Tatalaksana Melanoma Maligna Kutaneus
Authors: Chandra Rudi
Published: March 2023

Melanoma merupakan suatu tumor maligna dari melanosit, dengan lokasi paling sering adalah kulit (95% kasus). Tatalaksana melanoma tergantung stadium saat diagnosis; dengan pembedahan masih merupakan pilihan utama. Pengobatan melanoma primer adalah bedah eksisi definitif dengan batas eksisi berdasarkan ketebalan tumor. Pada keterlibatan nodus limfatikus regional, dapat dilakukan diseksi elektif komplit. Pada rekurensi lokal dilakukan bedah reseksi komplit dengan penutupan luka primer atau eksisi lokal luas disertai skin grafting ataupun penutupan flap. Metastasis melanoma dibedakan menjadi metastasis kulit atau jauh. Tatalaksana metastasis melanoma dapat berupa terapi sistemik (targeted therapy, terapi imun, dan kemoterapi) dan/atau radiasi. Terapi adjuvan diberikan hanya untuk pasien tanpa bukti metastasis tetapi berisiko tinggi penyebaran tumor lebih lanjut.

Melanoma is a malignant tumor of melanocytes, the most frequent location is in the skin (95% cases). Management of melanoma depends on the stage at diagnosis. Surgery is still the main choice of therapy. Treatment of primary melanoma is definitive excision surgery with excision limit based on the thickness of the tumor. In regional lymph node involvement, complete elective dissection can be performed. In local recurrence, complete resection is performed with primary wound closure or extensive local excision with skin grafting or flap closure. Treatment of melanoma metastasis can be divided into skin metastases or distant. Management of melanoma metastases can be systemic therapy (targeted therapy, immune therapy, and chemotherapy) and radiation. Adjuvant therapy is only given to patients without evidence of metastasis but is at high risk for further spread of the tumor.
Katarak Kongenital: Skrining dan Diagnosis
Authors: Priskila Taba Junetta Airene
Published: March 2023

Katarak kongenital merupakan kekeruhan lensa yang terjadi sejak lahir dan berpotensi menyebabkan gangguan penglihatan hingga kebutaan. Pemeriksaan red reflex pada bayi baru lahir sangat penting untuk deteksi dini kelainan tersebut. Pemeriksaan mata lanjutan untuk diagnosis antara lain slit-lamp, ultrasound, funduskopi, serta tajam penglihatan. Katarak kongenital yang mengganggu fungsi penglihatan dapat ditatalaksana dengan teknik operasi.

Congenital cataract is lens opacity that occurs since birth and can potentially cause visual impairment, even blindness. Red reflex examination in newborn is very important for early screening. Further diagnostic eye examination includes slit lamp, ultrasound, funduscopy, and visual acuity. Congenital cataract that impairs vision can be managed surgically.
Efektivitas N-Acetylsistein pada Pasien COVID-19
Authors: Sujana Karlina Sari , Maulida Munfika
Published: March 2023

COVID-19 disebabkan oleh virus SARS-Cov-2 dan menyebabkan morbiditas dan mortalitas yang tinggi. COVID-19 dapat menyebabkan pneumonia, sindrom gangguan pernapasan akut, perubahan kardiovaskular, dan kegagalan multi organ, yang dianggap berasal dari mekanisme badai sitokin, respons peradangan sistemik, dan serangan sistem kekebalan. N-acetylcysteine (NAC) telah digunakan dalam klinis untuk mengobati pasien sepsis dengan kondisi kritis. NAC memiliki karakteristik antioksidan, antiinflamasi, dan modulasi kekebalan yang bermanfaat menurunkan risiko perburukan COVID-19.

COVID-19 is caused by SARS-Cov-2 virus, and is known to cause high morbidity and mortality. COVID-19 causes pneumonia, acute respiratory distress syndrome, cardiovascular changes, and multi-organ failure, correlated to cytokine storm mechanisms, systemic inflammatory responses, and immune system attacks. N-acetylcysteine (NAC) has been used in clinical practice to treat sepsis patients with critical conditions. NAC has antioxidant, anti-inflammatory, and immune modulation characteristics beneficial to reduce the risk of COVID-19 worsening.
Tinjauan Klinis CADASIL (Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy)
Authors: Dwi Anandika Danar
Published: March 2023

CADASIL (cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy) adalah penyakit herediter langka dengan prevalensi 4,14 per 100.000. Penyakit ini disebabkan mutasi gen Notch 3 pada kromosom 19. Manifestasi klinisnya bervariasi dengan onset gejala awal migrain dengan aura. Pada tahap lanjut akan dijumpai lesi infark multipel di area subkortikal. Pasien juga dapat mengalami gangguan psikiatri dan neurobehaviour. Tidak ada terapi kausal, dapat diberikan terapi simptomatik.

CADASIL (cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy) is a rare hereditary disease with a prevalence of 4.14 per 100,000. The disease is caused by a mutation of the Notch 3 gene on chromosome 19. The clinical manifestations vary with the onset of initial symptoms is migraine with aura. In advanced stages, there will be multiple infarct lesions in the subcortical area. Patients may also experience psychiatric and neurobehavioral disorders. There is no causal therapy, only symptomatic therapy.
Pengaruh Coronavirus Disease 2019 (COVID-19) terhadap Insidens dan Tatalaksana Penyakit Serebrovaskular
Authors: Hamidjoyo Billy Priyanto , Wreksoatmodjo Budi Riyanto
Published: March 2023

COVID-19 dikenal dengan manifestasi klinis terkait saluran pernapasan seperti batuk, sesak, dan demam. Namun, saat ini telah banyak diteliti bahwa COVID-19 dapat menimbulkan gejala di luar sistem pernapasan, salah satunya ke sistem saraf. Pelaporan kejadian stroke pada pasien COVID-19 masih bervariasi, namun pada pasien COVID-19, khususnya yang bergejala berat terdapat kondisi hiperkoagulasi yang dapat menyebabkan komplikasi trombotik seperti trombosis vena dalam dan diduga berkaitan dengan risiko stroke pada pasien COVID-19.

COVID-19 is known for its clinical manifestations related to the respiratory tract such as cough, shortness of breath, and fever. However, currently it has been widely studied that COVID-19 can cause symptoms outside the respiratory system, one of which is the nervous system. Reports of stroke events in COVID-19 patients still vary, but in COVID-19 patients, especially those with severe symptoms, there is a hypercoagulable condition that can cause thrombotic complications such as deep vein thrombosis and is thought to be associated with the risk of stroke in COVID-19 patients.
Aspek Neurobiologi dan Neuroimaging Bunuh Diri
Authors: Safitri Dian Oktaria , AAAA. Kusumawardhani
Published: March 2023

Sejumlah 50% pelaku bunuh diri pernah melakukan percobaan bunuh diri sebelumnya. Sulitnya prediktor klinis dan tidak terdapatnya biomarker spesifik, menyulitkan prediksi perilaku bunuh diri. Perkembangan neurobiologi dan neuroimaging dapat memprediksi terjadinya upaya bunuh diri.

Fifty percent individuals who committed suicide have previously conducted suicide attempts. Rare clinical predictors and the absence of specific biomarkers, lead to difficulties in predicting suicidal behavior. Neurobiology and neuroimaging may predict the occurrence of suicide.
Diagnosis dan Tatalaksana Kegawatdaruratan Hiperkalemia
Authors: Teo Gloria
Published: March 2023

Hiperkalemia ialah kadar kalium plasma/ serum yang melebihi batas atas rentang normal, yaitu ≥5,5 mEq/L; dapat bervariasi tergantung cut off laboratorium dan sampel pemeriksaan. Hiperkalemia sering dijumpai di instalasi gawat darurat (IGD). Hiperkalemia berat dapat meningkatkan risiko mortalitas hingga 30%, karena menyebabkan aritmia yang mengancam nyawa, seperti fibrilasi ventrikel dan asistol. Hiperkalemia dapat disebabkan oleh perpindahan K+ intraseluler menuju ekstraselular, ekskresi inadekuat, dan intake K+ berlebih pada pasien gangguan ginjal. Tatalaksana hiperkalemia meliputi upaya menstabilkan miokard dan mencegah/ memperbaiki disritmia, redistribusi/pemindahan K+ menuju intraseluler, serta meningkatkan ekskresi K+.

Hyperkalemia is defined as a serum or plasma potassium level above the upper limits of normal range, usually ≥5,5 mEq/L; may vary depending on each laboratory cut off and sample. Hyperkalemia is the most common electrolyte disorder in emergency department. Severe hyperkalemia may increase the mortality up to 30% due to fatal arrhythmia, such as ventricular fibrillation and asystole. Hyperkalemia might be caused by potassium shift to extracellular compartment, inadequate excretion, and increased potassium intake in patients with decreased renal function. Management of hyperkalemia include myocardial stabilization and preventing/ improving dysrhythmia, redistribution/ shifting potassium back to intracellular compartment, and increasing potassium excretion.
PENGARUH MOTIVASI KERJA DAN DISIPLIN KERJA TERHADAP KINERJA PEGAWAI DINAS KETAHANAN PANGAN PROVINSI SULAWESI TENGGARA
Authors: A Ida Bagus Agung Surya , Mokodompit Eliyanti Agus , Hakim Adnan , Putera Asrip , Yusuf Yusuf
Published: March 2023

This study aims to examine and analyze the effect of work motivation and work discipline on employee performance. This study uses a sampling technique, namely a saturated sample of 60 samples consisting of secretaries, heads of divisions, heads of sections, and functional staff of the Food Security Service of Southeast Sulawesi Province. Methods of data collection using a questionnaire. The data analysis method uses multiple linear regression analysis with the help of the IBM SPSS Statistics Version 26 software application.The results of this study indicate that (1) work motivation partially has a positive effect on employee performance. (2) Work Discipline partially has a positive effect on employee performance. (3) Motivation and Work Discipline simultaneously have a positive effect on employee performance. The conclusion of this study is that the higher the work motivation, the higher the performance of the resulting employee as well as the higher the work discipline, the higher the employee's performance, and work motivation and work discipline have an interaction with employee performance.
PENGARUH KEPERCAYAAN MEREK DAN KEPUASAN KONSUMEN TERHADAP LOYALITAS MEREK MITSUBISHI XPANDER PADA PT. MAKASSAR MANDIRI PUTRA UTAMA
Authors: Al Qadri Adhitya , Rommy Nursaban , Sinarwaty Sinarwaty , Yusuf Hayat , Ittaqullah Nurul
Published: March 2023

This study aims to determine the effect of brand trust and consumer satisfaction on brand loyalty Mitsubishi Xpander at PT. Makassar Mandiri Putra Utama. The population in this study were all consumers at PT. Makassar Mandiri Putra Utama meanwhile, the sample is 30 samples. Data analysis was performed using multiple linear regression analysis techniques. The results showed that brand trust and consumer goals had a positive and significant effect on brand loyalty on Mitsubishi Xpander at PT. Makassar Mandiri Putra Utama
PENGARUH DIMENSI KUALITAS PRODUK TERHADAP KEPUTUSAN PEMBELIAN KARTU SELULER SIMPATI DI KOTA KENDARI
Authors: Heriyanto Heriyanto , Patwayati Patwayati , Nasrul Nasrul , Isalman Isalman , Istianandar Farhan Ramdhani
Published: March 2023

This study aims to determine both simultaneously and partially the effect of dimensions and product quality on the purchase of a simpathy cellular card in Kendari city. The population in this study is Kendari city residents who buy sympathy cards. Due to the infinite number of population, the determination of the sample used is accidental sampling. The data collection method in this study was to use a questionnaire. This study uses multiple linear regression analysis. The results showed that simultaneously and partially product quality and dimensions had a positive and significant effect on the purchase of a Simpati cellular card in the city of Kendari. That is, if the dimensions and quality of the product are good, it will tend to influence purchases
PENGARUH PENEMPATAN KERJA DAN KOMITMEN ORGANISASITERHADAP KINERJA KARYAWAN PADA PT. JASA RAHARJA CABANG SULAWESI TENGGARA
Authors: Hamzah Abdul Muin , Aliddin Laode Asfahyadin , Yusuf Abd. Razak , Nurwati Nurwati , Mahrani Sri Wiyati
Published: March 2023

This study aims: (1) To determine the effect of work placement and organizational commitment on employee performance at PT. Jasa Raharja Southeast Sulawesi Branch; (2) To determine the effect of Work Placement on employee performance; (3) To determine the effect of organizational commitment on employee performance. The population used in this study were all employees of PT. Jasa Raharja Southeast Sulawesi Branch, totaling 30 people who were also used as the respondent unit. The analysis used is quantitative analysis using Multiple Linear Regression Analysis. The results showed that; (1) Work placement and organizational commitment simultaneously have a significant positive effect on the performance of employees of PT. Jasa Raharja Southeast Sulawesi Branch; (2) Job placement has a significant positive effect on employee performance; (3) Organizational commitment has a significant positive effect on employee performance.
FUPOL: an Integrated Approach to Participative Policies
Authors: Tomic Rotim Silvana , Sonntagbauer Peter , Prister Giorgio
Published: March 2023

The Future Policy Modelling Project (FUPOL) is a research project funded by the 7th framework program of the European Union. Its research focus are new technologies and methods for e-governance, e-participation and policy modelling. The FUPOL consortium consists of partners from European countries, China and Kenya. and comprises innovative multinational companies, leading research institutes, high-level political organizations as well as strong pilot partners. This paper describes the FUPOL new integrated approach to policy design and implementation including also specific examples from real life pilots in cities from different countries. FUPOL consists of an advanced policy lifecycle and an IT-solution with features supporting all phases of the proposed lifecycle. The FUPOL concept and functional modules as well as the technical architecture to achieve such a complete integration are described.
Teaching Interaction Design and Children: Understanding the Relevance of Theory for Design
Authors: Bekker Tilde , Barendregt Wolmet , Markopoulos Panos , Read Janet
Published: March 2023

In this paper we address the challenge of teaching interaction design for children’s products especially pertaining to bridging the gap between child development theories and interaction design issues. We describe our experiences from developing a one-week course on interaction design and children, that is part of a competency based Masters program in design. We conclude that key elements in this course, to support learning how to incorporate theoretical knowledge in design, are a) providing design tool that covers a child developmental model of four domains (cognitive, social, emotional and physical) , such as the Developmentally Situated Design cards for creating child personas and design concepts b) using a design exercise c) giving students the possibility to work on several iterations d) giving students more than one age-group to work with in the project, and e) providing the students with an evaluation protocol.
Microscopic evaluation of fissure patterns of posterior permanent teeth: An in vitro study
Authors: Büyükgöze Dindar Mediha , Tekbaş Atay Meltem
Published: March 2023

Aim: Pits and fissures are considered the areas in the posterior teeth that are most susceptible to decay. The aim of this in vitro study was to evaluate the prevalence of fissure types in relation to tooth type and localization.
Methodology: A total of 100 extracted sound maxillary and mandibular molars and premolars were included in this study (25 teeth/group). The extracted teeth without any caries, cracks, fractures, anomalies, or restorations were classified according to tooth type and localization after disinfection. The teeth were sectioned in the buccolingual direction from the deepest part of the central fossa on the occlusal surface, and the fissure patterns were observed using a stereo microscope. The frequency distribution and percentages of the categorical data were obtained. Chi-square and exact tests were performed to compare the localization of the teeth and the prevalence of fissure types (p < 0.05).
Results: The V-type fissure pattern (59%) was statistically significantly more common in both the premolar and molar teeth, followed by the I-type (18%) and U-type (14%) patterns (p = 0.000). The rarest fissure pattern was the IK type. No relationships were found between fissure pattern, the tooth subgroups, and localization (p = 0.390).
Conclusion: Determining the types of fissure morphology is important for the prevention of caries on the occlusal surfaces of molars and premolars.
 
How to cite this article:
Büyükgöze Dindar M, Tekbaş Atay M. Microscopic evaluation of fissure patterns of posterior permanent teeth: An in vitro study. Int Dent Res 2022;12(3):107-11. https://doi.org/10.5577/intdentres.2022.vol12.no3.1
 
Linguistic Revision: The English in this manuscript has been checked by at least two professional editors, both native speakers of English.
Dental implant failure in immunosuppressed renal transplant patient: A case report
Authors: Güler Berceste , Terzioğlu Büşra , Çukurluöz Bayındır Banu , Dal Gülen
Published: March 2023

Background: In the literature, the dental implant survival rate has been reported one hundred percent in immunosuppressed patients after a solid organ transplant (SOT). There is no previously published dental implant failure that has been reported on immunosuppressed renal transplant, which is the most common SOT therapy.
Case Report: The case presented is that of a 66-years old male edentulous patient suffering from lack of functional prosthesis and who received a renal transplant two years ago. No complications such as infection, radiolucency, or pus were detected after two dental implants were placed in the mandible and after three months recovery period. The right mandibular dental implant failure occurred due to compression of the dental implant and healing head during the delivery of the patient’s removable prosthesis. Following implant socket healing after two months, the 4.8 mm diameter implant was placed immediately after. Osseointegration was completed uneventfully, and the patient was successfully rehabilitated with a two implant-retained mandibular overdenture prosthesis. The implant restoration was performing well with stable Peri-implant bone levels have shown minimal marginal bone loss at a 2-year follow-up. 
Conclusion: Treatment of combined immunosuppressive medication used in renal transplant patients after dental implant rehabilitation, as well as accompanying chronic diseases, should be performed considering the possibility of failure in dental implant applications. In this case report, the causes of implant failure were reported patients who received dental implant treatment after renal transplantation from a cadaver.
 
How to cite this article:
Güler B, Özaltun B, Çukurluöz Bayındır B, Dal G. Dental implant failure in immunosuppressed renal transplant patient: A case report. Int Dent Res 2022;12(3):171-5. https://doi.org/10.5577/intdentres.2022.vol12.no3.10
 
Linguistic Revision: The English in this manuscript has been checked by at least two professional editors, both native speakers of English.
The frequency and degree of expression of Carabelli’s trait on the permanent maxillary molars in a sample of Turkish individuals
Authors: Yılancı Hümeyra Özge , Özkan Gökhan , Akkaya Nursel , Boyacıoğlu Hatice
Published: March 2023

Aim: Carabelli’s trait, a morphological feature on the mesiopalatal surface of the maxillary molars, has importance in anthropology, forensic sciences, and clinical dentistry. The aim of this study was to find the frequency and degree of expression of Carabelli’s trait and to assess the asymmetry of the trait, on three permanent maxillary molars in a sample of Turkish individuals.
Methodology: Carabelli’s trait was evaluated using Dahlberg’s eight-grade scale on 462 subjects. Data were analyzed using a chi-square test.
Results: The frequencies in the total, positive and negative expressions of the trait were, respectively, 64.5%, 37.7% and 26.8% on the first molars, 27.1%, 19.6% and 7.6% on the second molars and 10.3%, 8.7% and 1.6% on the third molars. The occurrence of the trait on the first and second molars was more prevalent in males than in females. The trait was most frequently bilateral and symmetrical without significant sex differences, with varying degrees of asymmetry that increased from the first to the third molars. The frequencies of presence-absence asymmetry and any degree of asymmetry on the first molars were 5.3% and 15.7%, respectively.
Conclusion: This study revealed a comparatively high frequency of Carabelli’s trait with a relatively low asymmetry in a contemporary Turkish sample. This data has the potential to be used for anthropological, forensic, and clinical purposes.
 
How to cite this article:
Yılancı HÖ, Özkan G, Akkaya N, Boyacıoğlu H. The frequency and degree of expression of Carabelli’s trait on the permanent maxillary molars in a sample of Turkish individuals. Int Dent Res 2022;12(3):112-9. https://doi.org/10.5577/intdentres.2022.vol12.no3.2
 
Linguistic Revision: The English in this manuscript has been checked by at least two professional editors, both native speakers of English.
Движение в поле витка с током тела из анизотропного намагничивающегося эластомера с учетом взаимодействия с наклонной поверхностью
Authors: Меркулов Дмитрий Игоревич , Merkulov Dmitrii Igorevich , Пелевина Дарья Андреевна , Pelevina Daria Andreevna , Турков Владимир Андреевич , Turkov Vladimir Andreevich , Налетова Вера Арсеньевна , Naletova Vera Arsehyevna
Published: March 2023

В работе исследовано движение сферического тела из анизотропного намагничивающегося эластомера в вязкой жидкости под действием магнитного поля витка с током. Предложена математическая модель движения такого тела с учетом взаимодействия (качения, скольжения) с наклонной плоскостью. Построены расчетные траектории движения тела из начального положения на оси витка при включении магнитного поля. Определены параметры, при которых реализуется движение по наклонной поверхности. Вычислено максимальное отклонение тела от оси витка при различных параметрах задачи.
Геометрические факторы в задаче оценивания скорости самолета при помощи измерений трехлучевого лидара
Authors: Железнов Виктор Михайлович , Zheleznov Viktor Mikhailovich
Published: March 2023

Приводится исследование геометрических факторов в задаче оценивания скорости самолета при помощи измерений радиальных скоростей от трехлучевого доплеровского лидара. Подобные системы предлагается использовать в задачах авиационной гравиметрии как дополнение или как замену дифференциального скоростного решения спутниковой навигационной системы. Аналитическим способом получена оптимальная конфигурация направлений лучей лидара. Численным моделированием установлены конфигурации лучей, уменьшающие ковариацию ошибки оценивания вертикальной скорости самолета.
Evaluating the Impact of the Pandemic for the Low- and Middle-Income Countries Using Multimodal Data
Authors: Ding Zhiwei , Kong Jing
Published: March 2023

Compared with high-income countries, Low- and Middle-income Countries (LMICs) are characterized by large and dense populations with low standards of living. During major public health events, medical resources are often strained in LMICs. The COVID-19 pandemic has upended health and living standards around the world. This paper analyzes the impact of COVID-19 pandemic on medical resources in LMICs using multimodal data, including static attributes and epidemic time series data of countries. Specifically, we use the dynamic models to predict the maximum hospital demand and number of infections for the LMICs in the COVID-19 pandemic. The epidemic is estimated to impose health care burden excessively exceeding the current capacity of hospitals in many LMICs, especially in Honduras, Central African Republic, and Colombia. The reasons for the shortage of medical resources in these areas are further analyzed. We provide suggestion on coping with the shortage of medical resources in the COVID-19 era, as well as preparations for preventing major public health events in the future.
Segmentation of MR-guided, high intensity, focused ultrasound treated lesions based on diffusion-weighted imaging and interactive information
Authors: Liu Mingjia , Tang Na , Shen Guofeng
Published: March 2023

As the gold standard of traditional ablation treatment area, DCE-MRI has the disadvantages of slow imaging speed and only single examination during surgery. DWI is gradually being adopted as a new alternative. Considering the complex lesion status of uterine fibroids DWI, the interaction-based image segmentation method has a wider range of applications. Our proposed segmentation algorithm can be applied to a variety of cases and achieves a good segmentation Dice of 0.85.