bluuebunny/crossref_metadata_2025 huggingface dataset:
Longitudinal physiological remoulding of lower limb skin as a cause of diabetic foot ulcer: a histopathological examination
Authors: Imamura Yoshinobu , Suzuki Keiji , Saijo Hiroto , Tanaka Katsumi
Published: August 2022

Objective:

Diabetic foot ulcer (DFU) is recognised as a severe complication in patients with type 2 diabetes. With the increasing incidence of diabetes, it represents a major medical challenge. Several models have been proposed to explain its aetiology; however, they have never been assessed by longitudinal histopathological examination, which this study aims to address.

Method:

Multiplex-immunofluorescence analysis was carried out with lengthwise serial skin specimens obtained from the medial thigh, lower leg, ankle, dorsum of foot and acrotarsium close to the DFU region of a patient with type 2 diabetes receiving above the knee amputation.

Results:

Proximal-to-distal gradual loss of peripheral nerve was demonstrated, accompanied by compromised capillaries in the superficial papillary plexus and distended CD31-positive capillaries in the dorsum of foot. Neural fibres and capillaries were also significantly compromised in the sweat gland acinus in the ankle and dorsum of foot. Injuries in the superficial papillary plexus, sweat gland acinus, and sweat gland-associated adipose tissues were accompanied by significant infiltration of macrophages. These results indicated that longitudinal impairment of local blood circulation could be the cause of peripheral neuropathy, which initiated ulcer formation. Resultant chronic inflammation, involving sweat gland-associated adipose tissue, gave rise to impairment of wound healing, and thus DFU formation.

Conclusion:

Longitudinal histopathological examination demonstrated that impairment of local microvascular circulation (rather than the systemic complication caused by type 2 diabetes) was considered the primary cause of peripheral neuropathy, which initiated ulceration. Together with chronic inflammation in the superficial papillary plexus and sweat gland-associated adipose tissue, it resulted in the development of a DFU. Although this is a study of just one individual's limb, our study provided a unique observation, contributing mechanistic insights into developing novel intervening strategies to prevent and treat DFUs.
The Effects of Korean Medicine Treatment for Meniscus Tears: A Retrospective Chart Review
Authors: Park Ji-won , Jeong Myung-In , Jeong Wu-Jin , Hong Hae-Won , Koo Ji-eun , Bae Jun-Hyo , Kim Su-jin , Bae Ji-eun
Published: August 2022

Changes in symptoms and dysfunction related to meniscus tears following the use of Korean medicine for ≥ 4 days were studied. The medical charts of 53 cases of diagnosed meniscus tears (magnetic resonance imaging) with an admission Numeric Rating Scale (NRS) score ≥ 4, between 2017 and 2022 were retrospectively reviewed. Treatments included acupuncture, pharmacopuncture, herbal treatment, Chuna therapy, and physiotherapy. The NRS, Western Ontario and McMaster Universities Osteoarthritis Index, and European Quality of Life 5 Dimensions were performed at admission and discharge. There were 42 females and 11 males in this study. Patients were more likely to be in their 60s (38.18%), have an unknown etiology (81.13%), and have complex tears (50.94%). After receiving a combination of alternative Korean medicine during hospitalization, the mean NRS score improved from 6.82 ± 1.19 to 3.66 ± 1.83 (p < 0.001), the Western Ontario and McMaster Universities Osteoarthritis Index score improved from 46.47 ± 20.99 to 37.98 ± 19.23 (p < 0.001), and the mean European Quality of Life Five Dimensions score improved from 0.61 ± 0.18 to 0.68 ± 0.14 (p < 0.001) after treatment. These results suggest that Korean medicine treatment of meniscus tears alleviated pain and improved physical function.
Effectiveness of Electroacupuncture for Patients with Failed Back Surgery Syndrome: A Systematic Review and Meta-analysis
Authors: Shin Donghoon , Shin Kyungmoon , Jeong Hwejoon , Kang Deok , Yang Jaewoo , Oh Jihoon , Lim Jinwoong
Published: August 2022

Failed back surgery syndrome (FBSS) is a term that applies to symptoms such as persistent or recurring low back pain, paresthesia, sciatica, or numbness after spine surgery. Electroacupuncture (EA) has been reported to have excellent analgesic effects although there have been no systematic reviews on the effects of EA on FBSS. Therefore, a systematic review and meta-analysis of the effectiveness of EA on FBSS was conducted. Eight databases were searched for studies that used EA for FBSS and 7 randomized controlled trials (RCTs) were included. RCTs of EA as combination therapy for FBSS compared with conventional treatment demonstrated improvement in the level of pain, lumbar functional scale scores, and quality of life. However, meta-analysis showed that reduction in pain was not statistically significant, while evaluation of lumbar function significantly improved, although the quality of evidence in the RCTs was generally low. RCTs comparing EA alone with conventional treatment demonstrated an improved level of pain, lumbar function, and effective rate of treatment. Meta-analysis showed that pain was significantly decreased in the EA alone group compared with the control group, although the quality of evidence was low. To improve the quality of evidence, high-quality RCTs are required in the future.
Electroacupuncture Treatment for Primary Dysmenorrhea: A Review of Randomized Controlled Trials
Authors: Jeon Myung Kyu , Park Jae Eun , Lee Min Cheol , Kim Hyeon Jin , Ahn Jae Young , Shin Na Young , Nam Hye Jin , Chae Go Eun , Jo Hye Jeong , Kim Hyun Woo , Lee Young Jin , Koh Arha , Kim Woo Young
Published: August 2022

To evaluate the effectiveness of electroacupuncture treatment for primary dysmenorrhea (PD), a literature review of a randomized controlled trials (RCTs) was performed where electroacupuncture was used as a treatment intervention in patients diagnosed with PD. Relevant clinical studies (N = 226) were retrieved from multiple databases according to the study inclusion/exclusion criteria, and interventions and outcomes were analyzed. As a result of the review, there were 6 RCTs which met the criteria. In all 4 studies that measured pain indicators (visual analog scales), electroacupuncture showed significantly positive changes. In addition, positive changes were observed in most indicators (MMDQ, PGF2a, PGE2, 6-keto PGF1, TXB2, clinical efficacy score, uterine arterial blood flow parameters, and blood viscosity). 2 studies showed that electroacupuncture had a stronger therapeutic effect than NSAIDs. No major side effects were reported. Electroacupuncture may be an effective and safe treatment for PD however, further RCTs are required.
AS CONDIÇÕES DO TELETRABALHO FRENTE À CRISE DO COVID-19: DESAFIOS E PERSPECTIVAS.
Authors: Da Silva Wanessa Galindo Falcão , Oliveira João Pedro Cerqueira da Silva , Oliveira Neuza Vitoria de Andrade
Published: August 2022

O presente trabalho se propõe a analisar o protagonismo do teletrabalho durante a crise sanitária provocada pelo COVID-19.  Resgatamos um breve histórico sobre essa modalidade de trabalho, sua adoção no Brasil e no mundo, e as dificuldades e consequência da sua implantação. Por meio de consulta bibliográfica e de instrumentos legislativos, percebe-se que a legislação brasileira não abarca todas as peculiaridades do trabalho remoto, submetendo o teletrabalhador a condições precárias de trabalho.
O DIREITO FUNDAMENTAL À LIBERDADE DE EXPRESSÃO EM TEMPOS DE CRISE: A PRÁTICA DAS FAKE NEWS E DO DISCURSO DE ÓDIO NA DEMOCRACIA BRASILEIRA
Authors: Bispo Wallace Nascimento , Sousa Leite Jackson de Jesus
Published: August 2022

Artigo destinado a analisar o direito fundamental à liberdade de expressão, refletindo sobre o seu exercício durante o contexto pandêmico da COVID-19 (Sars-Cov-2) e, em um segundo plano, as crises político-social e jurídica, em que as notícias falsas, além do discurso de ódio, vêm sendo praticados afetando diretamente outros direitos fundamentais e a própria democracia. Assim, o tema, por relacionar-se às questões atuais, ao mesmo tempo preocupantes, haja vista as ameaças que tais práticas ensejam, se justifica para uma análise desses pontos no âmbito nacional, utilizando-se, para tanto, do método dedutivo. Para isto, a base da investigação se resume ao estudo de livros e artigos, jurisprudências e leis. Por fim, chegou-se às considerações de que o direito à liberdade de expressão não serve para proteger notícias inverídicas intencionalmente divulgadas, muito menos o discurso de ódio e ataques à democracia, além disso, considerou-se também que as liberdades individuais e os regimes democráticos são indissociáveis, tornando-se urgentes e necessárias a conscientização coletiva bem como uma solução legislativa-constitucional para tais práticas.
A RESPONSABILIDADE DAS AGÊNCIAS DE VIAGENS NO CANCELAMENTO E ATRASOS DE VOOS EM TEMPOS DE CRISE
Authors: Pereira Correia Álef Augusto
Published: August 2022

A presente pesquisa analisou as possibilidades de responsabilização de agências de viagens em casos de cancelamento, atrasos e desistências de voos decorrentes da crise do COVID-19. Inicialmente, tratou-se de entender o sistema de proteção assegurado no Código de Defesa do Consumidor e contextualização histórica e constitucional. O estudo aborda tanto a distinção entre as agências de viagens, operadoras de turismo e empresas de transporte aéreo como também os elementos jurídicos que compõe a caracterização e/ou exclusão da responsabilidade civil e ocorrências das chamadas práticas abusivas.
SISTEMAS PRODUTIVOS DE MORANGOS: AQUAPONIA COMO ALTERNATIVA PARA PRODUÇÃO DE ALIMENTOS SUSTENTÁVEL
Authors: Gomes Franco Mailson
Published: August 2022

A busca por técnicas produtivas em fruteiras que visam diminuir os impactos ambientais, melhorar a qualidade dos alimentos e potencializar os sistemas produtivos, minimizando a utilização de agroquímicos, tem se tornado cada vez mais frequentes no Brasil e no mundo.
Efeito do uso de Agrotóxicos sobre a população de vespas sociais (Hymenoptera – Vespidae) em áreas de cultivo de hortaliças em pequenas propriedades do município de Amélia Rodrigues-BA
Authors: Nascimento Campos Naiara
Published: August 2022

Das interações entre plantas e animais observadas na natureza, aquelas que ocorrem entre insetos e plantas são uma das que mais despertam atenção (WEST-EBERHARD et al., 1995).
Hybrid modeling of perovskite light-emitting diodes with nanostructured emissive layers
Authors: Chen Liyang , Gan Zhuofei , Zhang Yejin , Cai Wanqing , Wei Guo-Dan , Cui Dehu , Cai Jingxuan , Li Wen-Di
Published: August 2022

Perovskite light-emitting diodes (PeLEDs) have attracted much attention due to their superior performance. When a bottleneck of energy conversion efficiency is achieved with materials engineering, nanostructure incorporation proves to be a feasible approach to further improve device efficiencies via light extraction enhancement. The finite-difference time-domain simulation is widely used for optical analysis of nanostructured optoelectronic devices, but reliable modeling of PeLEDs with nanostructured emissive layers remains unmet due to the difficulty of locating dipole light sources. Herein we established a hybrid process for modeling light emission behaviors of such nanostructured PeLEDs by calibrating light source distribution through electrical simulations. This hybrid modeling method serves as a universal tool for structure optimization of light-emitting diodes with nanostructured emissive layers.
Photomodulated cryogenic temperature sensing through a photochromic reaction in Na0.5Bi2.5Ta2O9: Er/Yb multicolour upconversion
Authors: Li Peng , Zhang Zhen , Xu Ziyi , Sun Haiqin , Zhang Qiwei , Hao Xihong
Published: August 2022

Optical temperature sensing of the non-thermally coupled energy levels (N-TCLs) based on fluorescence intensity ratio (FIR) technologies has excellent temperature sensitivity and signal recognition properties. In this study, a novel strategy is established to enhance the low-temperature sensing properties by controlling photochromic reaction process in Na0.5Bi2.5Ta2O9: Er/Yb samples. The maximum relative sensitivity reaches up to 5.99% K−1 at cryogenic temperature of 153 K. After irradiation with commercial laser of 405 nm for 30 s, the relative sensitivity is increased to 6.81% K−1. The improvement is verified to originate from the coupling of optical thermometric and photochromic behaviour at the elevated temperatures. The strategy may open up a new avenue to improve the thermometric sensitivity in photo-stimuli response photochromic materials.
All-dielectric metalens for quasi-optical mode and polarization conversion
Authors: Han Meng , Fu Wenjie , Lu Dun , Zhang Chaoyang , Li Yunji , Yan Yang
Published: August 2022

Quasi-optical mode conversion technology plays a very important role in the development of high-power terahertz radiation sources. The ability of metamaterials to manipulate wave-front paves a new way in the field of quasi-optical mode conversion. In this paper, the approach for quasi-optical mode conversion by all-dielectric metalens and polarization conversion is proposed and investigated. Three metalens are designed to converter cylindrical waveguide TE01 mode to linear polarized (LP), left-hand circularly polarized (LHCP), and right-hand circularly polarized (RHCP) Gaussian beams at 350 GHz. Electromagnetic simulations show that the Gaussian mode contents of output waves from three metalens are all over 98% with high polarization contents. Furthermore, a metalens is designed for dual circularly polarized (DCP) which could convert cylindrical waveguide TE01 mode to LHCP and RHCP simultaneously. This work unveils the potential application for metalens in terahertz region.
Stabilized Dirac points in one-dimensional non-Hermitian optical lattices
Authors: Li Shan , Ke Shaolin , Wang Bing , Lu Peixiang
Published: August 2022

We demonstrate stable Dirac points (DPs) in low dimensions by taking advantage of non-Hermiticity in an optical lattice composed of two coupled Su–Schrieffer–Heeger chains. The occurrence of DPs stems from the constraints of pseudo-Hermiticity and charge-conjugation parity symmetry, which force the system to support both real bands and orthogonal eigenmodes despite its non-Hermitian nature. The two characteristics hold even at spectral degeneracies of zero energy, giving rise to non-Hermitian DPs. We show that DPs are stable with the variation of dissipation since they are topological charges and can develop into nodal rings in two dimensions. Moreover, we investigate the beam dynamics around DPs and observe beam splitting with stable power evolution. The study paves the way for controlling the flow of light to aid dissipation together with high stability of energy.
Archetypal Analysis for population genetics
Authors: Gimbernat-Mayol Julia , Dominguez Mantes Albert , Bustamante Carlos D. , Mas Montserrat Daniel , Ioannidis Alexander G.
Published: August 2022

The estimation of genetic clusters using genomic data has application from genome-wide association studies (GWAS) to demographic history to polygenic risk scores (PRS) and is expected to play an important role in the analyses of increasingly diverse, large-scale cohorts. However, existing methods are computationally-intensive, prohibitively so in the case of nationwide biobanks. Here we explore Archetypal Analysis as an efficient, unsupervised approach for identifying genetic clusters and for associating individuals with them. Such unsupervised approaches help avoid conflating socially constructed ethnic labels with genetic clusters by eliminating the need for exogenous training labels. We show that Archetypal Analysis yields similar cluster structure to existing unsupervised methods such as ADMIXTURE and provides interpretative advantages. More importantly, we show that since Archetypal Analysis can be used with lower-dimensional representations of genetic data, significant reductions in computational time and memory requirements are possible. When Archetypal Analysis is run in such a fashion, it takes several orders of magnitude less compute time than the current standard, ADMIXTURE. Finally, we demonstrate uses ranging across datasets from humans to canids.
Constructive connectomics: How neuronal axons get from here to there using gene-expression maps derived from their family trees
Authors: Kerstjens Stan , Michel Gabriela , Douglas Rodney J.
Published: August 2022

During brain development, billions of axons must navigate over multiple spatial scales to reach specific neuronal targets, and so build the processing circuits that generate the intelligent behavior of animals. However, the limited information capacity of the zygotic genome puts a strong constraint on how, and which, axonal routes can be encoded. We propose and validate a mechanism of development that can provide an efficient encoding of this global wiring task. The key principle, confirmed through simulation, is that basic constraints on mitoses of neural stem cells—that mitotic daughters have similar gene expression to their parent and do not stray far from one another—induce a global hierarchical map of nested regions, each marked by the expression profile of its common progenitor population. Thus, a traversal of the lineal hierarchy generates a systematic sequence of expression profiles that traces a staged route, which growth cones can follow to their remote targets. We have analyzed gene expression data of developing and adult mouse brains published by the Allen Institute for Brain Science, and found them consistent with our simulations: gene expression indeed partitions the brain into a global spatial hierarchy of nested contiguous regions that is stable at least from embryonic day 11.5 to postnatal day 56. We use this experimental data to demonstrate that our axonal guidance algorithm is able to robustly extend arbors over long distances to specific targets, and that these connections result in a qualitatively plausible connectome. We conclude that, paradoxically, cell division may be the key to uniting the neurons of the brain.
Ten simple rules for organizing a special session at a scientific conference
Authors: Chicco Davide , Bourne Philip E.
Published: August 2022

Special sessions are important parts of scientific meetings and conferences: They gather together researchers and students interested in a specific topic and can strongly contribute to the success of the conference itself. Moreover, they can be the first step for trainees and students to the organization of a scientific event. Organizing a special session, however, can be uneasy for beginners and students. Here, we provide ten simple rules to follow to organize a special session at a scientific conference.
Prescription quantity and duration predict progression from acute to chronic opioid use in opioid-naïve Medicaid patients
Authors: Johnson Drake G. , Ho Vy Thuy , Hah Jennifer M. , Humphreys Keith , Carroll Ian , Curtin Catherine , Asch Steven M. , Hernandez-Boussard Tina
Published: August 2022

Opiates used for acute pain are an established risk factor for chronic opioid use (COU). Patient characteristics contribute to progression from acute opioid use to COU, but most are not clinically modifiable. To develop and validate machine-learning algorithms that use claims data to predict progression from acute to COU in the Medicaid population, adult opioid naïve Medicaid patients from 6 anonymized states who received an opioid prescription between 2015 and 2019 were included. Five machine learning (ML) Models were developed, and model performance assessed by area under the receiver operating characteristic curve (auROC), precision and recall. In the study, 29.9% (53820/180000) of patients transitioned from acute opioid use to COU. Initial opioid prescriptions in COU patients had increased morphine milligram equivalents (MME) (33.2 vs. 23.2), tablets per prescription (45.6 vs. 36.54), longer prescriptions (26.63 vs 24.69 days), and higher proportions of tramadol (16.06% vs. 13.44%) and long acting oxycodone (0.24% vs 0.04%) compared to non- COU patients. The top performing model was XGBoost that achieved average precision of 0.87 and auROC of 0.63 in testing and 0.55 and 0.69 in validation, respectively. Top-ranking prescription-related features in the model included quantity of tablets per prescription, prescription length, and emergency department claims. In this study, the Medicaid population, opioid prescriptions with increased tablet quantity and days supply predict increased risk of progression from acute to COU in opioid-naïve patients. Future research should evaluate the effects of modifying these risk factors on COU incidence.
How can instructions and feedback with external focus be shaped to enhance motor learning in children? A systematic review
Authors: van der Veer Ingrid P. A. , Verbecque Evi , Rameckers Eugene A. A. , Bastiaenen Caroline H. G. , Klingels Katrijn
Published: August 2022

Aim

This systematic review investigates the effectiveness of instructions and feedback with external focus applied with reduced frequency, self-controlled timing and/or in visual or auditory form, on the performance of functional gross motor tasks in children aged 2 to 18 with typical or atypical development.

Methods

Four databases (PubMed, Web of Science, Scopus, Embase) were systematically searched (last updated May 31st 2021). Inclusion criteria were: 1. children aged 2 to 18 years old; 2. Instructions/feedback with external focus applied with reduced frequency, self-controlled timing, and/or visual or auditory form as intervention, to learn functional gross motor tasks; 3. Instructions/feedback with external focus applied with continuous frequency, instructor-controlled timing, and/or verbal form as control; 4. performance measure as outcome; 5. (randomized) controlled studies. Article selection and risk of bias assessment (with the Cochrane risk of bias tools) was conducted by two reviewers independently. Due to heterogeneity in study characteristics and incompleteness of the reported data, a best-evidence synthesis was performed.

Results

Thirteen studies of low methodological quality were included, investigating effectiveness of reduced frequencies (n = 8), self-controlled timing (n = 5) and visual form (n = 1) on motor performance of inexperienced typically (n = 348) and atypically (n = 195) developing children, for acquisition, retention and/or transfer. For accuracy, conflicting or no evidence was found for most comparisons, at most time points. However, there was moderate evidence that self-controlled feedback was most effective for retention, and limited evidence that visual analogy was most effective for retention and transfer. To improve quality of movement, there was limited evidence that continuous frequency was most effective for retention and transfer.

Conclusion

More methodologically sound studies are needed to draw conclusions about the preferred frequency, timing or form. However, we cautiously advise considering self-controlled feedback, visual instructions, and continuous frequency.

Trial registration

Registration: Prospero CRD42021225723. https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42021225723.
Home based postpartum care and determinants in Ethiopia: A multilevel analysis
Authors: Minuye Birhane Binyam , Alebachew Bayih Wubet , Chanie Muluken , Awoke Getaneh , Simegn Amare , Asnakew Sintayehu , Mamuye Melkalem , Yeshambel Abebaw , Muche Tewachew , Demis Asmamaw , Munye Tigabu , Endalamaw Aklilu , Eshetie Yeshambew , Kefale Demewoz , Chanie Ermias Sisay , Mengesha Yalew Zemen , Mesfin Belay Demeke
Published: August 2022

Introduction

Neonatal mortality remains a persisting public health challenge in Ethiopia. Timely intervention to neonatal morbidity and early neonatal care visit could reduce the burden of mortality. Studies related to home based postnatal care is limited in Ethiopia. Therefore, this study aimed to assess home based postnatal care visits and determinants in Ethiopia.

Methods

A secondary data analysis using 2016 EDHS data was conducted among 7590 women who had live births two years preceding the survey. A multilevel mixed-effect logistic regression analysis model was used and those variables with a P-value ≤ of 0.05 in multivariable analysis were considered as predictors. Results: Home based postpartum care by health care providers was 6.3% and 67.9% of women gave birth at home. Women perceived that distance is not big problem [AOR = 1.37; 95% CI: 1.06, 1.68], richer wealth index [AOR = 1.69; 95% CI: 1.15, 2.48], attending antenatal care visit [AOR = 2.17; 95% CI:1.57, 2.99], giving birth in health institution [AOR = 2.07; 95% CI:1.53, 2.80], giving birth by cesarean section [AOR = 3.41; 95% CI: 2.33, 4.99], and having awareness about neonatal danger sign [AOR = 3.68; 95% CI: 2.90,4.70] were factors associated with home based postpartum care.

Conclusion

Home based care by health care providers was low. Therefore, measures should be taken in increasing the number of nearby health care facility, strengthen the continuum of care on antenatal care follow-up, institutional delivery and improve mother’s knowledge about neonatal danger sign.
Factor structure and psychometric properties of Polish version of Parental Bonding Instrument (PBI) among adults and adolescents
Authors: Wajda Zbigniew , Izydorczyk Bernadetta , Sitnik-Warchulska Katarzyna , Lizińczyk Sebastian , Lickiewicz Jakub
Published: August 2022

Parental Bonding Instrument (PBI) by Parker et al., is a widely known and used tool in studies on the assessment of parenting behavior in adult, adolescent and child populations. This tool has had many translations and adaptations globally. In Poland, the factor structure and psychometric properties of PBI have not been studied so far. The aim of the presented research was to perform such an analysis both in the group of adults and adolescents. The data from four research projects, in which the 25-item version of the PBI translated into Polish was used, were analyzed. Data from 698 participants in total, including 473 adults and 225 adolescents were collected. Exploratory factor analyzes was performed for both mother and father version. A study of the reliability of individual factors, stability over time (test-retest) and an analysis of criterion validity were carried out. Both in the group of adults and adolescents, obtained a three-factor structure, acceptable reliability and stability over time. Moreover PBI correlated with another Polish tool in line with the adopted hypotheses, showing satisfactory criteria validity.
Semantic segmentation method of underwater images based on encoder-decoder architecture
Authors: Wang Jinkang , He Xiaohui , Shao Faming , Lu Guanlin , Hu Ruizhe , Jiang Qunyan
Published: August 2022

With the exploration and development of marine resources, deep learning is more and more widely used in underwater image processing. However, the quality of the original underwater images is so low that traditional semantic segmentation methods obtain poor segmentation results, such as blurred target edges, insufficient segmentation accuracy, and poor regional boundary segmentation effects. To solve these problems, this paper proposes a semantic segmentation method for underwater images. Firstly, the image enhancement based on multi-spatial transformation is performed to improve the quality of the original images, which is not common in other advanced semantic segmentation methods. Then, the densely connected hybrid atrous convolution effectively expands the receptive field and slows down the speed of resolution reduction. Next, the cascaded atrous convolutional spatial pyramid pooling module integrates boundary features of different scales to enrich target details. Finally, the context information aggregation decoder fuses the features of the shallow network and the deep network to extract rich contextual information, which greatly reduces information loss. The proposed method was evaluated on RUIE, HabCam UID, and UIEBD. Compared with the state-of-the-art semantic segmentation algorithms, the proposed method has advantages in segmentation integrity, location accuracy, boundary clarity, and detail in subjective perception. On the objective data, the proposed method achieves the highest MIOU of 68.3 and OA of 79.4, and it has a low resource consumption. Besides, the ablation experiment also verifies the effectiveness of our method.
Measurement of symphysis fundal height for gestational age estimation in low-to-middle-income countries: A systematic review and meta-analysis
Authors: Whelan Rachel , Schaeffer Lauren , Olson Ingrid , Folger Lian V. , Alam Saima , Ajaz Nayab , Ladhani Karima , Rosner Bernard , Wylie Blair J. , Lee Anne C. C.
Published: August 2022

In low- and middle-income countries (LMIC), measurement of symphysis fundal height (SFH) is often the only available method of estimating gestational age (GA) in pregnancy. This systematic review aims to summarize methods of SFH measurement and assess the accuracy of SFH for the purpose of GA estimation. We searched PubMed, EMBASE, Cochrane, Web of Science, POPLINE, and WHO Global Health Libraries from January 1980 through November 2021. For SFH accuracy, we pooled the variance of the mean difference between GA confirmed by ultrasound versus SFH. Of 1,003 studies identified, 37 studies were included. Nineteen different SFH measurement techniques and 13 SFH-to-GA conversion methods were identified. In pooled analysis of five studies (n = 5838 pregnancies), 71% (95% CI: 66–77%) of pregnancies dated by SFH were within ±14 days of ultrasound confirmed dating. Using the 1 cm SFH = 1wk assumption, SFH underestimated GA compared with ultrasound-confirmed GA (mean bias: -14.0 days) with poor accuracy (95% limits of agreement [LOA]: ±42.8 days; n = 3 studies, 2447 pregnancies). Statistical modeling of three serial SFH measurements performed better, but accuracy was still poor (95% LOA ±33 days; n = 4 studies, 4391 pregnancies). In conclusion, there is wide variation in SFH measurement and SFH-to-GA conversion techniques. SFH is inaccurate for estimating GA and should not be used for GA dating. Increasing access to quality ultrasonography early in pregnancy should be prioritized to improve gestational age assessment in LMIC.
Short-form adaptive measure of financial toxicity from the Economic Strain and Resilience in Cancer (ENRICh) study: Derivation using modern psychometric techniques
Authors: Xu Cai , Smith Grace L. , Chen Ying-Shiuan , Checka Cristina M. , Giordano Sharon H. , Kaiser Kelsey , Lowenstein Lisa M. , Ma Hilary , Mendoza Tito R. , Peterson Susan K. , Shih Ya-Chen T. , Shete Sanjay , Tang Chad , Volk Robert J. , Sidey-Gibbons Chris
Published: August 2022

Objectives

This study sought to evaluate advanced psychometric properties of the 15-item Economic Strain and Resilience in Cancer (ENRICh) measure of financial toxicity for cancer patients.

Methods

We surveyed 515 cancer patients in the greater Houston metropolitan area using ENRICh from March 2019 to March 2020. We conducted a series of factor analyses alongside parametric and non-parametric item response theory (IRT) assessments using Mokken analysis and the graded response model (GRM). We utilized parameters derived from the GRM to run a simulated computerized adaptive test (CAT) assessment.

Results

Among participants, mean age was 58.49 years and 278 (54%) were female. The initial round factor analysis results suggested a one-factor scale structure. Negligible levels of differential item functioning (DIF) were evident between eight items. Three items were removed due to local interdependence (Q3>+0.4). The original 11-point numerical rating scale did not function well, and a new 3-point scoring system was implemented. The final 12-item ENRICh had acceptable fit to the GRM (p<0.001; TLI = 0.94; CFI = 0.95; RMSEA = 0.09; RMSR = 0.06) as well as good scalability and dimensionality. We observed high correlation between CAT version scores and the 12-item measure (r = 0.98). During CAT, items 2 (money you owe) and 4 (stress level about finances) were most frequently administered, followed by items 1 (money in savings) and 5 (ability to pay bills). Scores from these four items alone were strongly correlated with that of the 12-item ENRICh (r = 0.96).

Conclusion

These CAT and 4-item versions provide options for quick screening in clinical practice and low-burden assessment in research.
Spatial variation and factors associated with home delivery after ANC visit in Ethiopia; spatial and multilevel analysis
Authors: Ayalew Hiwotie Getaneh , Liyew Alemneh Mekuriaw , Tessema Zemenu Tadesse , Worku Misganaw Gebrie , Tesema Getayeneh Antehunegn , Alamneh Tesfa Sewunet , Teshale Achamyeleh Birhanu , Yeshaw Yigizie , Alem Adugnaw Zeleke
Published: August 2022

Introduction

Institutional delivery is crucial to reduce maternal and neonatal mortality as well as serious morbidities. However, in Ethiopia, home delivery (attended by an unskilled birth attendant) after antenatal care (ANC) visit is highly in practice. Therefore, this study aimed to assess the spatial variation and determinants of home delivery after antenatal care visits in Ethiopia.

Method

A secondary data analysis was conducted using the 2019 mini Ethiopian demographic and health survey. A total of 2,923 women who had ANC visits were included. Spatial analysis was done by using GIS 10.7 and SaTscan 9.6. The risk areas for home delivery from GIS and spatial scan statistics results were reported. A multi-level logistic regression model was fitted using Stata14 to identify individual and community-level factors associated with home delivery after ANC visit. Finally, AOR with 95% CI and random effects were reported.

Result

Home delivery after ANC visit was spatially clustered in Ethiopia(Moran’s index = 0.52, p-value <0.01). The primary clusters were detected in Oromia and SNNP region (LLR = 37.48, p < 0.001 and RR = 2.30) and secondary clusters were located in Benishangul Gumuz, Amhara, Tigray and Afar (LLR = 29.45, p<0.001 and RR = 1.54). Being rural resident (AOR = 2.52; 95%CI 1.09–5.78), having no formal education (AOR = 3.19;95% CI 1.11–9.16), being in the poor (AOR = 2.20;95%CI 1.51–3.22) and middle wealth index (AOR = 2.07;95% CI 1.44–2.98), having one ANC visit (AOR = 2.64; 95% CI 1.41–4.94), and living in the agrarian region (AOR = 3.63; 95%CI 1.03–12.77) had increased the odds of home delivery after ANC visit.

Conclusion and recommendation

Home delivery after ANC visit was spatially clustered in Ethiopia. Factors like maternal education, wealth index, number of ANC visits, residency and region were significantly associated with home delivery after ANC visit. Therefore, it is better to increase the number of ANC contact by giving health education, especially for women with low levels of education and better to improve the wealth status of women. A special strategy is also vital to reduce home delivery after ANC visit in those high-risk regions.
Factors associated with Facebook addiction among university students amid the COVID-19 pandemic: Findings from an online cross-sectional survey
Authors: Ripon Rezaul Karim , Al Zubayer Abdullah , Rahman Quazi Maksudur , Khan Abid Hasan , Rahaman Arifur , Hasan M. Tasdik , Bhuiyan Md. Rifat Al Mazid , Khan Md. Kamrul Ahsan , Chowdhury Md. Ashraf Uddin , Hossain Md. Zakir
Published: August 2022

Background

Facebook addiction (FA) has been suggested as a potential behavioral addiction. There is a severe lack of research evidence regarding the Facebook addiction behavior among university students during the ongoing COVID-19 pandemic. The aim of this study was to determine factors associated with Facebook addiction among Bangladeshi university students.

Methods

A cross-sectional online survey was conducted among 2,161 Bangladeshi university students during the COVID-19 pandemic from June 2021 to September 2021. A well fitted regression model in R programming language was used for this study.

Results

Female respondents and those whose family monthly income was <25,000 BDT were more addicted to Facebook than other respondents. Respondents who lost a family member or a relative to COVID-19, engaged in physical activities (exercise) during the pandemic, used Facebook for work purposes or used Facebook to relieve daily stress were more addicted to Facebook.

Conclusion

Overuse of social media is problematic as it can trigger several mental health symptoms, especially among students. Adequate and effective interventions are required to educate students about the dangers of Facebook addiction and to provide an alternative, healthy options.
COVID-19 and prices of pulses in Major markets of India: Impact of nationwide lockdown
Authors: Paul Ranjit Kumar , Yeasin Md
Published: August 2022

The COVID-19 pandemic has impacted almost all the sectors including agriculture in the country. The present paper investigates the impact of COVID-19 induced lockdown on both wholesale and retail prices of major pulses in India. The daily wholesale and retail price data on five major pulses namely Lentil, Moong, Arhar, Urad and Gram are collected for five major markets in India namely Delhi, Mumbai, Kolkata, Chennai and Hyderabad during the period January, 2019 to September, 2020 from Ministry of Consumer Affairs, Food & Public Distribution, Government of India. The Government of India declared nationwide lockdown since March, 24, to May, 31, 2020 in different phases in order to restrict the spread of the infection due to COVID-19. To see the impact of lockdown on price and price volatility, time series model namely Autoregressive integrated moving average (ARIMA) model with error following Generalized autoregressive conditional heteroscedastic (GARCH) model incorporating exogenous variable as lockdown dummy in both mean as well variance equations. It is observed that in almost all the markets, lockdown has significant impact on price of the pulses whereas in few cases, it has significant impact on price volatility.
Changes in the oxygen isotope composition of the Bering Sea contribution to the Arctic Ocean are an independent measure of increasing freshwater fluxes through the Bering Strait
Authors: Cooper Lee W. , Magen Cédric , Grebmeier Jacqueline M.
Published: August 2022

A large volume of freshwater is incorporated in the relatively fresh (salinity ~32–33) Pacific Ocean waters that are transported north through the Bering Strait relative to deep Atlantic salinity in the Arctic Ocean (salinity ~34.8). These freshened waters help maintain the halocline that separates cold Arctic surface waters from warmer Arctic Ocean waters at depth. The stable oxygen isotope composition of the Bering Sea contribution to the upper Arctic Ocean halocline was established as early as the late 1980’s as having a δ18OV-SMOW value of approximately -1.1‰. More recent data indicates a shift to an isotopic composition that is more depleted in 18O (mean δ18O value ~-1.5‰). This shift is supported by a data synthesis of >1400 water samples (salinity from 32.5 to 33.5) from the northern Bering and Chukchi seas, from the years 1987–2020, which show significant year-to-year, seasonal and regional variability. This change in the oxygen isotope composition of water in the upper halocline is consistent with observations of added freshwater in the Canada Basin, and mooring-based estimates of increased freshwater inflows through Bering Strait. Here, we use this isotopic time-series as an independent means of estimating freshwater flux changes through the Bering Strait. We employed a simple end-member mixing model that requires that the volume of freshwater (including runoff and other meteoric water, but not sea ice melt) flowing through Bering Strait has increased by ~40% over the past two decades to account for a change in the isotopic composition of the 33.1 salinity water from a δ18O value of approximately -1.1‰ to a mean of -1.5‰. This freshwater flux change is comparable with independent published measurements made from mooring arrays in the Bering Strait (freshwater fluxes rising from 2000–2500 km3 in 2001 to 3000–3500 km3 in 2011).
Decellularized small intestine submucosa device for temporomandibular joint meniscus repair: Acute timepoint safety study
Authors: Chung William L. , Brown Bryan N. , Almarza Alejandro J.
Published: August 2022

Temporomandibular joint (TMJ) Meniscus removal is an option for the patient to regain full range of motion if the disc is irreversibly damaged or unable to be reduced. However, this procedure leaves the joint vulnerable to condylar remodeling and degeneration. We have shown that extracellular matrix (ECM) scaffolds remodel into a tissue with near native TMJ meniscus in previous studies. The next step towards clinical translation is to manufacture the ECM scaffold as a device under good manufacturing practices (GMP) and test it in a pre-clinical animal study under good laboratory practices (GLP). The primary objective of this study was to evaluate the in-vivo histopathological response to a Prototype GMP manufactured device made of decellularized porcine small intestinal submucosa (SIS), by observing for signs of surrounding tissue reaction to the device that are indicative of an adverse host response in comparison to an empty control at 21 days post-surgical implantation in a canine TMJ meniscus removal and implant model in a GLP setting. The conclusive findings were that the ECM device is safe for placement in the TMJ. After 21 days post implantation, histology of tissue surrounding the device and draining lymph nodes showed that the Prototype GMP device had no negative effects compared to the empty site (as evaluated by the board-certified veterinary pathologist). Furthermore, there was a lack of negative findings for clinical pathology (hematology and clinical chemistry), mortality, and body weight/weight change. Future studies will go to one year after implantation to show that the remodel device remains as a viable tissue with near native mechanical properties.
Biomechanical study of anterior and posterior pelvic rings using pedicle screw fixation for Tile C1 pelvic fractures: Finite element analysis
Authors: Song Yuanzheng , Shao Changsheng , Yang Ximing , Lin Feng
Published: August 2022

Objective

The purpose of this study was to analyse the biomechanical characteristics of pedicle screws with different placement methods and diameters in the treatment of Tile C1 pelvic fractures by finite element simulation technology and to compare them with the plate fixation model to verify the effectiveness of pedicle screw fixation.

Methods

A three-dimensional digital model of a normal pelvis was obtained using computed tomography images. A finite element model of a normal pelvis containing major ligaments was built and validated (Model 1). Based on the verified normal pelvis finite element model, a Tile C1 pelvic fracture model was established (Model 2), and then a plate fixation model (Model 3) and a pedicle screw fixation model with different screw placement methods and diameters were established (Models 4–15). For all pelvic fracture fixation models, a vertical load of 500 N was applied on the upper surface of the sacrum to test the displacement and stress distribution of the pelvis in the standing state with both legs.

Results

The finite element simulation results showed the maximum displacement of Model 1 and Models 3–15 to be less than 1 mm. The overall maximum displacement of Models 4–15 was slightly larger than that of Model 3 (the maximum difference was 177.91×10−3mm), but the maximum displacement of iliac bone and internal fixation in Models 4–15 was smaller than that of Model 3. The overall maximum stress (maximum stress of the ilium) and maximum stress of internal fixation in Models 4–15 were less than those in Model 3. The maximum displacement difference and maximum stress difference at the fracture of the pubic ramus between each fixed model were less than 0.01 mm and 1 MPa, respectively. The greater the diameter and number of pedicle screws were, the smaller the maximum displacement and stress of the pelvic fracture models were.The maximum displacement and stress of the pelvic fracture models of the screws placed on the injured side of the pubic region were smaller than the screws on the healthy side.

Conclusion

Both the anterior and posterior pelvic rings are fixed with a pedicle screw rod system for treatment of Tile C1 pelvic fractures, which can obtain sufficient biomechanical stability and can be used as a suitable alternative to other implants.The greater the diameter and number of pedicle screws were, the greater the pelvic stability was, and the greater was the stability of the screws placed on the injured side of the pubic region than the screws on the healthy side.
Effectiveness of graded motor imagery protocol in phantom limb pain in amputed patient: Protocol of a randomized clinical trial
Authors: Rierola-Fochs Sandra , Merchán-Baeza Jose Antonio , Minobes-Molina Eduard
Published: August 2022

Objective

The aim of this study is to analyse the effectiveness of the Graded Motor Imagery (GraMI) protocol in phantom limb pain in amputee patients.

Materials and methods

A randomised clinical trial will be conducted, with two parallel groups and simple blinding, and a phenomenological study with semi-structured interviews. People over the age of 18, with amputation of one limb, with a minimum score of 3 on the visual analogue scale of pain, who are pharmacologically stable and have been discharged from hospital, will be recruited. An initial assessment, a post-intervention assessment (9 weeks) and a follow-up assessment (12 weeks post-intervention) will be performed, in which pain, quality of life, functionality and psychological aspects will be assessed. The aim of the qualitative study is to find out about the experience of living with phantom limb pain and to identify the satisfaction with the intervention. A descriptive, univariate and bivariate quantitative statistical analysis will be performed using the SPSS program, with a 95% confidence level and a statistical significance level of p < 0.05. The qualitative analysis will be carried out using the Atlas.ti 8.0 program, where the different interviews will be analysed, coded and categorised.

Discussion

The GraMI protocol allows the patient to work on motor learning through brain reorganisation, analytical movements, sensory stimulation, and functional activities. In addition, it can help to standardise the use of graded motor imagery in future studies and in clinical practice with this patient profile.

Trial registration

NCT05083611.