bluuebunny/crossref_metadata_2025 huggingface dataset:
Efficacy of tildrakizumab 200 mg for treating difficult-to-treat patient populations with moderate to severe plaque psoriasis
Authors: Dapavo Paolo , Megna Matteo , Talamonti Marina
Published: August 2024

Psoriasis is an inflammatory chronic disease of the skin typically located on the extensor surfaces of the body, and the trunk. Patients with psoriasis can often present multiple characteristics, such as lesions located in difficult-to-treat (DTT) areas or a high severity of the disease, which can negatively affect their quality of life. There is a lack of consensus in identifying the best therapy for these complex patient populations, especially after the failure of one or multiple lines of therapy. In this regard, we report a case series describing patients with psoriasis located in different DTT areas or presenting a high Psoriasis Area and Severity Index score at baseline and treated ineffectively with prior lines of therapy. Finally, patients achieved complete remission following therapy with tildrakizumab 200 mg (anti-IL-23p19), highlighting its potential efficacy in these patient populations.
Chronic prostatitis/chronic pelvic pain syndrome induces metabolomic changes in expressed prostatic secretions and plasma
Authors: Zhang Fang-Xing , Chen Xi , Niu De-Cao , Cheng Lang , Huang Cai-Sheng , Liao Ming , Xue Yu , Shi Xiao-Lei , Mo Zeng-Nan
Published: August 2024

Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is a complex disease that is often accompanied by mental health disorders. However, the potential mechanisms underlying the heterogeneous clinical presentation of CP/CPPS remain uncertain. This study analyzed widely targeted metabolomic data of expressed prostatic secretions (EPS) and plasma to reveal the underlying pathological mechanisms of CP/CPPS. A total of 24 CP/CPPS patients from The Second Nanning People’s Hospital (Nanning, China), and 35 asymptomatic control individuals from First Affiliated Hospital of Guangxi Medical University (Nanning, China) were enrolled. The indicators related to CP/CPPS and psychiatric symptoms were recorded. Differential analysis, coexpression network analysis, and correlation analysis were performed to identify metabolites that were specifically altered in patients and associated with various phenotypes of CP/CPPS. The crucial links between EPS and plasma were further investigated. The metabolomic data of EPS from CP/CPPS patients were significantly different from those from control individuals. Pathway analysis revealed dysregulation of amino acid metabolism, lipid metabolism, and the citrate cycle in EPS. The tryptophan metabolic pathway was found to be the most significantly altered pathway associated with distinct CP/CPPS phenotypes. Moreover, the dysregulation of tryptophan and tyrosine metabolism and elevation of oxidative stress-related metabolites in plasma were found to effectively elucidate the development of depression in CP/CPPS. Overall, metabolomic alterations in the EPS and plasma of patients were primarily associated with oxidative damage, energy metabolism abnormalities, neurological impairment, and immune dysregulation. These alterations may be associated with chronic pain, voiding symptoms, reduced fertility, and depression in CP/CPPS. This study provides a local-global perspective for understanding the pathological mechanisms of CP/CPPS and offers potential diagnostic and therapeutic targets.
Fournier’s Gangrene Following Acute Gastroenteritis in a Female Infant
Authors: Abubakar Muhammad Shakur , Ahmadu Ibrahim , Aliyu Suleiman Dada , Aliu-Isah Oiza Ozioroko
Published: August 2024

Background:

Fournier’s gangrene (FG) is a rare necrotizing infection of the genital and perineal structures. It can be very fatal, especially when appropriate treatment is delayed.

Clinical Description:

A 17-month-old girl presented with acute diarrhea, fever, and perineal ulceration. The perineal ulcer started as reddish rashes on the 3rd day of diarrhea, which rapidly progressed to form a large ulcer the next day. She was critically ill and in heart failure at presentation.

Management and Outcome:

After stabilization, investigations and cultures were taken. She had hyponatremia, hypokalemia, and neutropenia. The wound swab and blood culture yielded Pseudomonas
aeruginosa and coagulase-negative Staphylococcus aureus (methicillin resistant). She was treated with antibiotics, wound debridement and other supportive care. She recovered fully from her acute illness with complete healing of the ulcer.

Conclusion:

This case report brings to the fore the possibility that acute diarrhea in the presence of other predisposing factors may cause FG. Early recognition and prompt management by multidisciplinary team can result in successful outcomes.
Pattern and management of missile injury to the oral and maxillofacial region: A 12-year experience during Boko Haram insurgency in Maiduguri, North-Eastern Nigeria
Authors: Ahmad Mukhtar Modibbo , Suleiman Ibrahim Kayode , James Olutayo , Olasoji Hector Oladapo , Sanda Abubakar Kaka , Shehu Ibrahim Muhammad , Shehu Yusha`u Abdullahi
Published: August 2024

Introduction:

Missile injury is a global public health problem, which occurs in both military and civilian settings. Boko Haram insurgency in North-Eastern Nigeria is one of the major violence the country experienced that resulted in many civilian casualties. This study was aimed at exploring the various patterns of the missile injuries to the maxillofacial region during Boko Haram insurgency.

Methods:

In this retrospective cross-sectional study, relevant information was retrieved from patient records including sociodemographic, causes of missile injuries, site of injuries, pattern of presentation, treatment, and the complications, and analysed using SPSS version 23.

Result:

A total of 526 patients with various maxillofacial injuries were seen during this 12-year study period, with age ranging from 4 to 65 years, the peak incidence in the age group 31–40 years, 89.5% were males, 92.9% of the injuries were allegedly inflicted by insurgents and comprised of 61.0% gunshot injuries, 24.5% bomb blast, and machete cuts 7.4%. Most of the injuries occurred in the lower third of the face, 39.8%, and mandible was the commonest fractured facial bone.

Conclusion:

Facial injuries commonly are associated with devastating consequences to survivors and, hence, may require long time monitoring and psychosocial rehabilitations.
Doppler sonographic characteristics and clinical outcomes of diabetic foot syndrome: A 5-year audit from a tertiary hospital in northern Nigeria
Authors: Ismail Anas , Lawal Yusuf , Gezawa Ibrahim D. , Ramalan Mansur Aliyu , Uloko Andrew E. , Usman Mustapha Ibrahim
Published: August 2024

Background:

Diabetes foot syndrome is one of the common complications of diabetes. Detailed information on the clinical and vascular characteristics of patients with diabetic foot disease in relation to the outcome of the care provided to these patients will be useful to policymakers and clinicians in early detection and timely interventions for the prevention of disabling complications.

Materials and Methods:

This is a review of patients with diabetic foot managed in Aminu Kano Teaching Hospital over 5 years (January 2017–May 2022). The sociodemographic characteristics, Wagner classification of the foot, Doppler sonographic characteristics and clinical outcomes, etc., were reviewed.

Results:

A total of 51 patients were reviewed. Males and females accounted for 56.8% and 43.1%, respectively. Twenty-five patients had Wagner grade 4 ulcers, and fewer patients had Wagner grade 1 and 5-foot ulcers. The mean ± standard deviation Doppler arterial intimal media thickness was 1.53 ± 0.33 (range 0.90–2.40 mm). The majority of DFS patients had Doppler sonographic lesions on the right lower limb 28 (54.9%) only, and 11 (21.6%) of the lesions were bilateral. The posterior tibial artery 11 (21.6%) was the most involved arterial segment with plaques, followed by a combination of popliteal and tibial arterial 10 (19.6%) segments. At 6 months, 45.2% had limb amputation, 17.6% healed ulcers, 17.6% delayed wound healing, and 9.8% died.

Conclusion:

There is an unacceptably high prevalence of poor treatment outcomes, thus, contributing to a huge burden of care to patients living with diabetes. There is a strong association between severe arterial stenosis detected by Doppler ultrasound and higher rates of amputations.
Embryonal rhabdomyosarcoma of the prostate: Clinico-pathological highlights with review of literature
Authors: Singh Anshima , Phulware Ravi Hari , Kumar Arvind , Kishore Sanjeev
Published: August 2024

Rhabdomyosarcoma (RMS) is the third most common extra-cranial sarcoma occurring in childhood, adolescents, and young adults (AYAs); and is rare in adults. Literature about RMS mainly considers RMS in AYAs, either with that in the children or adults, even though histological, molecular, and clinical characteristics of RMS in AYAs are significantly different from either of the two. Herein, we report a case of prostatic embryonal RMS, in a 17-year-old boy, along with the review of literature of prostatic RMS, with emphasis on AYAs. Our patient presented with clinical complaints of acute urinary retention, Grade IV prostatomegaly and, low serum prostate-specific-antigen (0.11ng/dl). The diagnosis was clinched by prostatic biopsy, which revealed diffuse ‘small round blue cell’ tumour admixed with larger rhabdomyoblasts, displaying positivity for desmin and myogenin, on immunohistochemistry. Clinicians should be mindful that RMS is found in all age groups ranging from childhood to adults; however, the clinical, histological, and molecular features are different. RMS in AYAs is often treated according to the guidelines provided for the paediatric age group. Treatment mostly comprises a multimodality approach, including surgery with/without chemo- and radiotherapy. Prognosis in AYAs is worse than in children but is better than in adults. Thus, early diagnosis gains utmost importance to provide comparatively more probability of rendering treatment and, hopefully, a better quality of life.
Prevalence of anaerobic bacteria in surgical site infections in Lagos University Teaching Hospital
Authors: Chukwuma Stella Tochukwu , Balogun Olanrewaju Samuel , Oduyebo Oyinlola O. , Oshun Philip O. , Osuagwu Chioma S. , Rotimi Vincent O.
Published: August 2024

Background:

Surgical site infection (SSI) is the second most common cause of nosocomial infection, after urinary tract infection. Sequelae of SSI include increased healthcare costs and worse patient outcomes. There is a paucity of research studies on the impact of anaerobic organisms on SSIs in Nigeria. The aim of this study was to determine the role of anaerobic bacteria in SSI encountered at the Lagos University Teaching Hospital (LUTH).

Materials and Methods:

A total of 438 patients were consecutively recruited into this study from general surgery, obstetrics and gynaecology and paediatric units of the LUTH from 1 July through 31 December 2019. Two surgical wound specimens were collected from all patients with suspected SSIs. One was for anaerobic culture using Brucella blood agar incubated in an anaerobic jar that secured anaerobiosis using the anaerobic gas pack. The other swab was used for aerobic culture on blood agar incubated on air at 37oC. Identifications and antibiotic sensitivity testing were performed according to standard laboratory procedures.

Result:

The overall incidence of SSI in the study was 12.3%. The incidence of anaerobic SSI was 1.1%. The distribution of anaerobic infections by medical specialty unit was as follows; general surgery (1.6%), obstetrics and gynaecology (0.8%) and paediatrics (0.9%). Bacteroides species was the only anaerobic isolate. The risk factors associated with the development of SSI by multiple logistic regression analysis were duration of surgery greater than 2 h (OR 1.418; 95% CI 1.834–9.286; P = 0.001) and NNIS risk index 2 and 3 – (OR 2.165; 95% CI 2.366–32.086; P = 0.001).

Conclusions:

The prevalence of anaerobic SSI was 1.1%. Duration of surgery greater than 2 h and NNIS risk index 2 and 3 were independent predictors of SSI.
Validation of using smartphone based non-mydriatic camera for retinal photography to diagnose diabetic retinopathy
Authors: Banakar Ravindra , Anepla R Suresha , Pushparaj Yogaasri , Bhatt Kunal Prakashchandra
Published: August 2024

Purpose:

To assess the sensitivity and specificity of retinal imaging captured by portable non-mydriatic ‘fundus on phone’ camera as a screening tool against the conventional seven field digital fundus photography.

Design:

Prospective comparative study design.

Methods:

Study was performed over 300 diabetic patients (600 eyes). First fundus pictures were taken with non-mydriatic ‘fundus-on-phone’ camera and then with Zeiss seven field fundus camera after pupillary dilation. Images were analysed and compared by two observers.

Results:

Out of all the 600 undilated fundus images, 15.5% were ungradable, 76% were graded as poor and average quality by both observers. From the dilated fundus images taken using Zeiss camera, only 0.8% images were found ungradable by both observers. The sensitivity and specificity for detecting any diabetic retinopathy changes and its severity by using ‘fundus-on-phone’ camera against Zeiss fundus camera were found to be 54.92% and 85.5%, respectively, by observer one and 56.48% and 85.5%, respectively, by observer two.

Conclusion:

Non-mydriatic retinal imaging using fundus-on-phone camera is not a feasible method for screening diabetic retinopathy due to low sensitivity and high number of poor-quality images.
Posterior segment optical coherence tomography: A diagnostic aid in posterior uveitis
Authors: Danayak Parul M. , Chaudhary Rupal M. , Shah Zalak
Published: August 2024

Background:

Patients with posterior uveitis can develop vision-threatening complications. Optical coherence tomography (OCT) plays an important role in the diagnosis and management of these complications.

Aims:

The objectives of this study were to describe different retinal morphological characteristics presenting on OCT in patients with posterior uveitis, with an aim to facilitate early diagnosis to initiate specific treatment and also to observe the response to treatment.

Materials and Methods:

A cross-sectional prospective non-randomized study was undertaken at a tertiary eye care hospital. The study included 30 eyes of 30 patients with posterior uveitis between the period of May 2016 and May 2018. All subjects underwent a set of systemic investigations for etiological diagnosis and complete ophthalmic examination, including OCT (Zeiss Cirrus machine (model number 5000)] imaging). Data were collected and analyzed. A P value of <0.05 was considered statistically significant.

Results:

The mean patient age was 33.1 ± 4.2 years. Infectious etiology was diagnosed in 13 patients (43.33%) of which toxoplasma chorioretinitis (36.66%) was the most common infection. Among 17 patients with noninfectious uveitis (56.66%), Vogt-Koyanagi-Harada (VKH) disease and multifocal choroiditis (16.67% each) were the most common causes. RPE-Bruch’s membrane abnormalities were seen in 96.67% of patients. Subretinal detachment (26.67%) was the most common type of macular edema on OCT. Significant differences in central foveal thickness posttreatment were noted in cases with VKH syndrome and toxoplasma retinochoroiditis (P < 0.05).

Conclusion:

OCT is a useful tool complementary to conventional fundus photography and fluorescein angiography in patients with posterior uveitis.
The Relationship Between Caring Nursing Education Students and Caring Preceptors at Regional General Hospital
Authors: Setyawan Daniel Bagus , Supratno Haris , Roesminingsih Erny
Published: August 2024

Objective: This study aims to improve collaborative skills and student learning outcomes in science subjects by using the teaching at the right level (TaRL) learning approach by utilizing Canva media in the learning process. Method: The research method used was classroom action research involving 32 students of class 8B at Junior High School 3 Madiun. The research stage uses the Kemmis & Mc. Taggar model. The survey was conducted in two cycles. Each cycle consists of two meetings including the stages of planning, implementation of actions, observation and reflection. The data sources used in the study are observations during learning, tests, and learning evaluation results.  Results:  Showing a positive impact of learning using the TaRL approach by using Canva learning media, especially on collaborative skills and student learning outcomes. The results of observation and evaluation showed an improvement in collaboration skills and learning outcomes after implementing the TaRL approach through Canva's learning media.  Novelty: This research has a novelty because the use of the TaRL approach with Canva media will bring out students' creativity so that cohesiveness with the team is established, design learning that allows students to obtain learning concepts, and make it easier for teachers to apply this approach in science learning.
Strategic Leadership of School Principals in Enhancing Character Education in the Digital Literacy Era
Authors: Lukmantoro Dhanu , Hariyati Nunuk , Riyanto Yatim , Setyowati Sri
Published: August 2024

Objective: This research aims to explore the strategies employed by school principals to enhance character education through digital literacy at 3rd Sidoarjo State Senior High School, providing detailed insights into goal-setting processes and strategies. Method:  The study utilizes a qualitative approach, involving informants such as school principals, vice principals, subject teachers, and education staff. Data collection includes interviews, field notes, and other relevant materials. Systematic data analysis is performed by categorizing, synthesizing, and identifying patterns to derive meaningful findings. Results:  The findings reveal significant positive impacts on students, teachers, parents, and the school environment. Students show improved discipline, reduced delinquency, and enhanced digital responsibility. Teachers display better attendance and a deeper understanding of their role as role models. Increased parental involvement in school activities fosters a collaborative atmosphere. The school's management and community engagement have also improved, contributing to a supportive educational environment. Novelty: This study uniquely integrates character education with digital literacy, demonstrating a holistic approach to educational enhancement. It highlights the interconnectedness of ethical digital behavior and character development, offering a comprehensive model for other schools to emulate. The research underscores the importance of continuous evaluation and the inclusion of diverse perspectives to sustain and evolve effective character education programs in the digital age.
Scientific Literacy Profile of Prospective Science Teacher Students
Authors: Sarini Putri , Widodo Wahono , Sutoyo Suyatno , Suardana I Nyoman
Published: August 2024

Objective: This research aims to describe and analyze the scientific literacy achievements of prospective science teacher students. Scientific literacy is one of the skills that prospective science teacher students must master to promote scientific literacy at the primary and secondary education levels. Method: This research is a quantitative descriptive research. Data was collected using a purposive sampling technique so that a sample of 65 students from the Bachelor of Science Education Study Program at Ganesha University of Education was obtained. The research instrument used was the Test of Scientific Literacy Skills (TOSLS) which consisted of 28 multiple-choice questions. This research is a preliminary study of research and development (R&D) of innovative science learning models to increase students' scientific literacy. Results: The results of the research show that the literacy achievement of prospective science teacher students is very low with the scientific literacy achievement in the aspect of identifying and assessing inquiry methods that contribute to scientific knowledge at very low and the aspect of compiling, analyzing, and understanding quantitative data and scientific information of very low. Novelty: This research provides an overview of the scientific literacy achievements of prospective science teacher students which can be used as a basis for developing innovative science learning models to increase the scientific literacy of prospective science teacher students.
The Impact of Servant Leadership, Supervision Competence, and Teacher Performance on School Quality
Authors: Thai' Atun Waldatun , Hanafi M. Syadeli , Faturohman Nandang , Suryadi Suryadi
Published: August 2024

Objective: This study examines the correlation between servant leadership, supervisory competency, and teacher performance in school quality. Method: The results of this investigation were confirmed by employing a statistical survey approach. The structural equation model's PLS-SEM method for prediction was used to generate the values of the latent variables. The research sample comprised nineteen principals and two hundred thirty-one elementary school teachers from the Ciwandan sub-district of Cilegon City in Banten Province. Results: Structural model statistical studies show a positive relationship between servant leadership and supervisory competence. Supervision competency and school quality are not positively correlated. Servant leadership is positively correlated with teacher performance, and teacher performance is positively correlated with school quality. Novelty: The novelty of this research is that there are differences in emphasis, research participants, and integration of research components compared to other research. This study introduces novel research integrating servant leadership, supervisory competency, and teacher performance in school quality. This innovative research integrates multiple variables into a single unit for investigation and analysis.
Instrument Development of Design Thinking Test for Graphic Design Students
Authors: Patria Asidigisianti Surya , Ekohariadi Ekohariadi , Sutiadiningsih Any , Kristiana Nova , Prihadi Kususanto Ditto
Published: August 2024

Objective:  Design thinking is one of the methods used to carry out the design process. So, in solving this design problem, design students, especially Graphic Design students, should carry out the stages of design thinking for the work design process. The measurement of design thinking ability is a written exam to get a standardized assessment. This Research aims to describe the development of a design thinking test instrument for graphic design students. Method: The design thinking test instrument consists of 30 multiple-choice questions. After the questions were completed, five experts validated the question. The results of content validation to five experts were analyzed using the Content Validity Ratio. The question was then tested on 30 Unesa Graphic Design students. The results of each question item were tested for validity through the Rasch model with the STATA Program and ConQuest. Results:  To test the reliability of the instrument using Cronbach Alpha. The result is CVR scoring between 0.500 and 1.000, and the alpha Reliability value exceeds 0.881. The results of the total item correlation test vary from -0.0391 to 0.465, while the INFIT MNSQ value of the Rasch model starts with a value of 0.500 to 1.300. Novelty: It is concluded that the written test assessment instrument is empirically valid, so the design thinking skills assessment instrument is feasible to use.
Analysis of the Effectiveness of Pop-Up Book Media on Science Learning in Elementary Schools
Authors: Zaniyati Maharani , Rohmani Rohmani
Published: August 2024

Objective: Science education in elementary schools provides basic scientific knowledge and skills and develops students' critical and creative thinking abilities. This study aims to analyze the effectiveness of using pop-up books as media in learning science in elementary schools. Method: In this study, researchers applied the Systematic Literature Review (SLR) method using the Google Scholar database. The literature search focused on the initial keyword "learning media," restricted from 2019 to 2024, resulting in 86,200 articles. Furthermore, with the addition of the keyword "pop-up book," 4,120 articles were found. Then, adding the last keyword, "science in elementary school," resulted in 318 articles. From this number, data selection and eligibility tests were carried out to obtain suitable articles until 11 appropriate articles were obtained and by the literature review's objectives. Results:  Based on the study's results, it can be concluded that pop-up book media has proven effective in learning science in elementary schools. Novelty: For educators, engaging learning media in learning science is recommended to convey the learning material well and effectively, including pop-up books.
Changes in the CDX2 protein and cytokeratins CK20, K7 expression in the gastric mucosa in schoolchildren with Helicobacter pylori-associated gastritis
Authors: Vshivkov Vitaliy A. , Polivanova Tamara V.
Published: August 2024

The effect of carcinogenic factors such as bacterial invasion of Helicobacter pylori on the expression of CK20, CK7 cytokeratins and the distribution of CDX2 protein in the epithelium of the gastric mucosa (CO) and the pathophysiological significance of these processes have not yet been sufficiently studied. Aim: to determine changes in the distribution of CDX2 protein and the expression of cytokeratins CK20, K7 in the gastric mucosa in schoolchildren with Helicobacter pylori-associated gastritis. To evaluate the association between the expression of CDX2 and cytokeratins CK20, CK7 in the epithelium of the gastric mucosa in schoolchildren with gastritis under conditions of bacterial invasion by H. pylori.
Materials and methods. Esophagogastroduodenoscopy was performed with taking biopsies from the gastric mucosa in eighty nine 7–17 years children with gastroenterological complaints. The morphological method confirmed the diagnosis of gastritis and determined the presence of H. pylori infection. Biopsies were examined immunohistochemically to identify the proteins CDX2, CK20, CK7 in the gastric epithelium.
Results. A more pronounced expression of CK7 was noted in the body of the stomach with H. pylori-associated gastritis in 7–11 year schoolchildren, in comparison with those examined without H. pylori (p = 0.003) and with infected 12–17 years schoolchildren (p = 0.017). There were were revealed differences in the expression of CK20 in the antrum, which were absent in uninfec­ted girls and were lower than in girls with bacterial invasion (p = 0.024). Also in girls with H. pylori and in the body of the stomach, CK7 expression was higher (p = 0.045). Among uninfected patients, there was an increase in CK20 expression in the antrum in boys compared to girls, and to greater extent, this concerned the older age group (p = 0.006). While the increased expression of CK7 in schoolchildren of the younger age group primarily affected girls infected with H. pylori in both parts of the stomach. In the body of the stomach, the highest level of CK7 was also observed in H. pylori-associated gastritis 7–11 years old girls (p = 0.004). The association of CDX2 with H. pylori invasion has not been established.
Conclusion. Thus, in schoolchildren with gastritis, there was detected an expression of CK20, CK7 and CDX2 in the epithelium of the gastric mucosa, with features of its severity and a close association with the gender and age characteristics of the child.
Managerial and methodological measures to support breastfeeding in the implementation of the Federal project “Open Maternity Hospital”
Authors: Butskaya Tatyana V.
Published: August 2024

Introduction. In modern conditions, it is necessary to support breastfeeding and develop a set of measures for personalized optimization of a woman’s nutrition at all stages: from conception planning and pregnancy to the postpartum period and the entire period of breastfeeding.
The purpose of the work is to determine the effectiveness of using a set of measures aimed at promoting breastfeeding in the model of the updated form of the Federal project “Open Maternity Hospital”.
Materials and methods. In 2018, the Expert and Educational Center “Parents’ Choice” developed the Federal project “Open Maternity Hospital”, which included a set of managerial and methodological measures aimed at optimizing the nutrition of nursing women and the implementation of the Program for breastfeeding have been developed, tested and approved by specialists, both for consultants and for parents. In 2023, the Federal project “Open Maternity Hospital” has been significantly modified, expanded and updated its information base. By May 2024, 14 regions and one hundred thirty five maternity hospitals had joined the project. The updated version of the project included developed recommendations on the nutrition in lactating women and the promotion of breastfeeding.
Results. The analysis of data on the implementation of the updated project form showed the Federal project “Open Maternity Hospital” to open up new opportunities for the protection of maternal and infant health in various regions of the country as it creates conditions that favourably affect the increase in fertility in the region and provides personalized information work to identify the quality of medical care for women with disabilities. It is an additional means of formation a positive image of the medical institutions and the regional health authority; improves the conditions for the prevention of postpartum depression and other disorders in women after childbirth and during the first year of the infant life; improves the effectiveness of measures to optimize breastfeeding; improves parents’ awareness of safe and high-quality nutrition in infants; expands the possibilities of using the target audience of the project for operational sociological surveys.
Conclusion. The model of the updated form of the Federal project “Open Maternity Hospital”, developed on the initiative and with the direct participation of the author, is an accessible method in the regions for the active introduction into healthcare of a set of measures aimed at promoting breastfeeding, raising awareness of medical workers and nursing women to optimize breastfeeding and nutrition of women during breastfeeding. It serves as a modern means of expanding the communicative conditions for medical personnel, this is important for improving the quality of medical care to the population.
Stem Cell Treatment for Acute Lymphoblastic Leukemia in Adults
Authors: Gallicchio Vincent S
Published: August 2024

Stem cell therapy used to treat Acute Lymphoblastic Leukemia in adults (ALL) has been one of the more promising uses of stem cells and has large implications on the survival rate of adults with ALL. While the survival rate of ALL remains relatively low at an estimated 20% to 30% in adults, stem cell as an adjunct therapy has shown promising results. Historically, ALL has a high rate of recurrence in adults and one study aims to assess the effectiveness of hematopoietic stem cell therapy in diminishing the rates of recurrence. Stem cell therapy for blood diseases is most found in the form of an allogeneic bone marrow transplant, which includes transplantation of HSCs from a donor. It can help to stimulate the body to produce healthy blood cells and thereby keep the disease at bay. The study concluded that HSCT increases the survival rate of adults with ALL and that it should be considered if a patient has a viable donor available. We see that multiple other studies come to similar conclusions, such as one study that found increased long-term disease-free survival can be achieved through stem cell therapy. A culmination of incredible research excites the idea of an extraordinary step forward in helping to cure those suffering from acute lymphoblastic leukemia and improve long-term, disease-free survival.
Pemanfaatan Lingkungan Alam Sekitar dalam Pelaksanaan Pembelajaran IPAS Berbasis Etnosains di SDK Olabolo
Authors: Yovita Maria Pawe  , Yovita Awu  , Yosefina Uge Lawe  , Ernesta Menge
Published: August 2024

Tujuan dari penelitian ini adalah untuk menilai bagaimana Lingkungan Hidup digunakan dalam pengajaran Ilmu Pengetahuan dan Teknologi berdasarkan Etnosains di SDK Olabolo. Fokus penelitian adalah pada pendidikan ilmu sosial di SDK Olabolo, dan pesertanya adalah guru dari kelas I hingga VI. Penelitian ini bersifat kualitatif dan deskriptif, dan menggunakan wawancara, observasi, dan dokumentasi sebagai metode pengumpulan data. Peneliti yang melakukan penelitian lapangan menemukan bahwa di SDK Olabolo, pembelajaran IPAS hanya terjadi di kelas. Ini melibatkan penyediaan materi, tugas, ceramah, dan cerita tanpa praktikum atau proyek apa pun untuk meningkatkan keterampilan psikomotorik siswa. Akibatnya, pembelajaran berbasis kelas membuat siswa merasa tidak tertarik dan tidak terlibat. Tingkat keterampilan psikomotorik dan aktivitas belajar siswa di kelas dapat menurun sebagai akibatnya. Peneliti merekomendasikan agar guru meningkatkan sistem pembelajaran di kelas sehubungan dengan masalah ini. Salah satu cara untuk mencapai hal tersebut adalah dengan memanfaatkan lingkungan alam di sekitar sekolah sebagai sumber belajar. Berdasarkan lingkungan alam lingkungan Olabolo SDK, jelas bahwa ada hutan yang tersedia untuk digunakan sebagai sumber daya pendidikan bagi siswa, halaman sekolah, taman sekolah, dan taman bunga, yang dapat meningkatkan proses pembelajaran. Berdasarkan temuan peneliti, dapat disimpulkan bahwa pemanfaatan lingkungan alam di sekitar SDK Olabolo sangat efektif dalam menerapkan pembelajaran IPAS.
Analisis Kesulitan Mahasiswa dalam Menyelesaikan Soal Statistik pada Prodi Teknik Informasi di Universitas X Nusa Tenggara Barat
Authors: Andrianingsih Vivi , Sahrul Sahrul , Asmoro Eddi Indro , Samsudin Samsudin
Published: August 2024

Statistika dapat diartikan sebagai metode atau asas guna mengerjakan dan memanipulasi data kuantitatif agar angka berbicara. Penelitian ini lakukan di Universitas X Nusa Tenggara Barat pada prodi teknik informatika. Soal yang diberikan berjumlah 10 butir item yang  terdiri: 3 butir mencari modus,  3 butir mencarai median,  3 butir menghitung rata-rata (mean) dan 1 butir menghitung uji regresi linear sederhana. Mahasiswa sebagai subyek dalam penelitian dapat menyelesaikan soal dengan cara hitung manual dulu kemudian dilanjutkan dengan membandingkan hasil hitungan bantuan aplikasi SPSS, subyek dalam penelitian ini berjumlah 28 orang. Adapun tujuanya untuk mengetahui  tingkat kesulitan mahasiswa dalam menyelesaikan soal statistik. hasil penelitian yang dilakukan pada Universitas X Nusa Tenggara Barat prodi teknik informasi bahwa tingkat pemahaman mahasiswa dalam  menyelesaikan soal yang terdiri dari  mencari modus dengan rata-rata yang diperoleh sebesar 65,82. Pada  mencai median rata-rata 63,82. Sedangkan menghitung mean sebesar 66,75 dan menghitung uji regresi linear sederhana terdapat 58,18. Sehingga dapat disimpulakn bahwa mahasiswa tingkat kesulitannya berada pada kategori sedang.
Analysis of Vousinas Fraud Hexagon Theory on the Detection of Financial Statement Fraud in Service Companies Listed on Indonesia Stock Exchange (IDX) 2018-2022
Authors:   Faculty of Economics and Business, University of Nort Sumatera, Medan, Indonesia, Utami Amalia , Bukit Rina Br. ,   Faculty of Economics and Business, University of Nort Sumatera, Medan, Indonesia, Aulia Adnans Abdhy ,   Faculty of Economics and Business, University of Nort Sumatera, Medan, Indonesia
Published: August 2024

The aims of this research was to identify and determine the influence of financial targets, external auditor quality, total accruals to total assets, CEO educational background, managerial ownership, political relations, and cooperation with government projects on financial statement fraud in Infrastructure, Utilities and Transportation Sector Service Companies Listed on the IDX 2018-2022, both partial and simultaneous influence, also moderated influence by internal control system. This research is explanatory research design with the sampling technique used purposive sampling. The population in this research is companies in infrastructure, utility and transportation sector listed on IDX with total 79companies. The research sample was obtained with total 44 companies. The type of data used is secondary data with data analysis techniques used panel data regression models and moderated regression analysis (MRA) through Eviews 10 software. This research found that Financial Target, External Auditor Quality, CEO Educational Background, Political Connection have a significant effect on Financial Statement Fraud in Infrastructure, Utilities and Transportation Sector Companies listed on the IDX. While Total Accrual to Total Asset, Managerial Ownership, and Cooperation with Government Project have no influence on Financial Statement Fraud. This study also found that Internal Control is able to moderates the relationship between Return on Asset, External Auditor Quality, Total Accrual to Total Asset, CEO Educational Background, Managerial Ownership, Cooperation with Government Project and Financial Statement Fraud in Infrastructure, Utilities and Transportation Sector Service Companies listed on the IDX.
The Relationship between the Sexual Abstinence Period and Semen Parameters in Oligozoospermic and Asthenozoospermic Infertile Men
Authors:   Pathological Analyses Department /Faculty of Science, University of Kufa, Al-Murshedy Dr. Sahib , Issa Gasp Shanbara ,   Pathological Analyses Department /Faculty of Science, University of Kufa, mouhsen Hoda thaher ,   Pathological Analyses Department /Faculty of Science, University of Kufa, Noman Esraa Fawzy ,   Pathological Analyses Department /Faculty of Science, University of Kufa, Salman Maryam Hamoudi ,   Pathological Analyses Department /Faculty of Science, University of Kufa
Published: August 2024

The present study aimed to evaluate the correlation between sexual abstinence period and semen parameters in oligozoospermic and asthenozoospermic infertile men. this study was carried out in laboratories of fertility center in Alsader hospital in province of Najef, and in laboratories of faculty of science, Kufa university in Iraq. oligozoospermic and asthenozoospermic groups were selected in this study .semen analysis was conducted for two both groups according to WHO guidelines, and the correlation between semen parameters and abstinence period were studied. Our study involved a study of the correlation between the abstinence period and sperm parameters in both two group, oligozoospermia and asthenozoospermia. In the correlation between sperm parameters and abstinence period, the oligozoospermia group showed no significant differences (p>0.05) .While the asthenozoospermia group revealed nonsignificant diffrences in the correlation between abstinence period and sperm concentration and progressive motility percent and it revealed to find a significant correlation (r=0.20;p=0.047) between abstinence period and normal sperm morphology percent. abstinence period has not any effect on sperm parameters in oligozoospermia but there is positive correlation between sexual abstinence period and normal sperm morphology in asthenozoospermia. Study of corelation between abstinence period and ROS and DNA fragmentation for oligo and astheno spermia groups.
Amalan Kepimpinan Transformasional Guru Besar dan Hubungannya Terhadap Kualiti Guru Berdasarkan Standard 4 SKPMg2
Authors: Perumal Vani
Published: August 2024

Tujuan penyelidikan ini adalah untuk menganalisis perkaitan antara kaedah kepimpinan transformasi pengetua sekolah dengan kualiti guru SKPMg2 darjah empat mereka di Daerah Segamat. Seratus dua puluh guru sekolah kebangsaan dari kawasan Segamat merupakan subjek kajian deskriptif ini yang menggunakan kaedah tinjauan. Penulis menggunakan kedua-dua statistik deskriptif dan inferensi untuk meneliti data yang datang daripada tinjauan yang telah ditadbir. Dapatan kajian menunjukkan bahawa pengetua di daerah Segamat terlibat dalam kaedah kepimpinan transformasi yang sangat berkesan. Menurut SKPMg2 standard 4, kualiti guru juga baik. Kualiti pendidik sesebuah sekolah berkorelasi positif dengan kehadiran kepimpinan transformasi. Komponen utama yang mempengaruhi kaliber pendidik ialah salah satu ciri kepimpinan transformatif—pengaruh ideal. Hasil penyelidikan ini menunjukkan bahawa kepimpinan transformatif adalah penting untuk meningkatkan tahap pendidik dan taraf pendidikan di seluruh Daerah Segamat.
Gestão do cronograma e atendimento das demandas de um escritório de arquitetura e urbanismo localizado no estado do Rio de Janeiro - BR
Authors: Fonseca Isabela Rocha Lima Palmer , Gonçales Filho Manoel
Published: August 2024

Este trabalho ocorre em torno da gestão de cronogramas de um escritório de arquitetura e urbanismo localizado no Estado do Rio de Janeiro-Brasil. Foram estudadas a rotina, demanda e gestão do escritório por inteiro. O objetivo foi desenvolver e implementar uma metodologia eficiente para a distribuição de equipes e tarefas dentro do cronograma, visando otimizar o fluxo de trabalho, reduzir desperdícios e aumentar a transparência e eficiência organizacional. Para a metodologia utilizou-se da abordagem qualitativa e o procedimento técnico foi o estudo de caso. Os resultados, foram: melhor estruturação de modelos de gestão no escritório, aliados a métodos, “softwares”, gráficos e programas que possibilitem uma leitura clara e didática da gestão, tornando-a transparente e legível por toda a equipe.
A música no contexto da teoria histórico-cultural de Vigotski
Authors: Trevezani Eglieni , Pereira Morila Ailton
Published: August 2024

A arte existe na sociedade desde as primeiras civilizações. Dentre as diversas expressões artísticas, a música é uma das mais antigas e se destaca por seu caráter subjetivo e abstrato. Com o passar do tempo, ficou claro que a relação entre as pessoas e a música se tornou cada vez mais importante e inevitável, e diante disso, ressaltamos a importância de compreender o impacto da música no desenvolvimento humano e seu impacto na vida do sujeito, visualizando a música como um fenômeno psicológico e cultural. Para tanto, exploraremos o conceito de arte de Vigotski sob a ótica da teoria histórico-cultural, então, apresentaremos a música, e utilizaremos como método uma revisão da literatura. O possível impacto sobre o tema abre caminho para o trabalho na formação continuada de professores. Nessa perspectiva, acreditamos que a música pode mudar o estado físico e mental do sujeito, possibilitando que ele supere seus sentimentos e mude seu mundo.
Superando desafios educacionais e pessoais
Authors: Soares Paula Raquel da Rocha , Yamaguchi Klenicy Kazumy de Lima
Published: August 2024

O presente trabalho visa relatar a experiência de uma aluna do Programa Residência Pedagógica (PRP), inserida na Licenciatura em Química, durante um dos momentos mais desafiadores enfrentados pela educação contemporânea: a pandemia do Covid-19. O interesse em descrever os desafios, medos e angústias vivenciados pela acadêmica se deve ao contexto caótico imposto pela pandemia, somado ao fato de estar grávida, oferecendo uma perspectiva de superação de limites. A pandemia teve seu início em dezembro de 2019, na China, e foi declarada pela Organização Mundial de Saúde como uma pandemia global em fevereiro de 2020. Isso levou ao fechamento de fronteiras, suspensão de atividades comerciais, lazer, escolas e universidades. O isolamento social tornou-se a estratégia primordial para conter a propagação do vírus, causando um período inesperado e prolongado de alterações significativas no modo de vida, que se estendeu até 2023, com a disseminação das vacinas e a redução da transmissão do vírus. Por fim, a experiência obtida durante este processo tem contribuído para que a aluna pudesse, não só compreender o contexto da educação e ensino, por meio do ingresso no Programa Residência Pedagógica, mas também constatar a sua enorme força em superar limites e barreiras, pois, durante o processo pandêmico gerou-se em quase toda a população um sentimento de medo e angustia que foram superados aos poucos, com o avanço da ciência e no caso do relato acompanhado a acadêmica também passou por um processo de gravidez, que por si só, já gera muita insegurança em grande parte das mulheres.
Analisis Pengaruh Motivasi Kerja, Disiplin Kerja, dan Kompensasi Terhadap Kinerja Karyawan pada CV. Siuk Body Repair
Authors: Daffa Adhipratama Fahrizal , Kusdiyanto
Published: August 2024

The purpose of this research is to analyze the effect of work motivation, work discipline, and compensation on employee performance. By using a quantitative approach. The population in the study were all workers at Cv. Siuk Body Repair and the research sample was 50 employee taken with saturated sampling technique. The data analysis method used is data instrument test, classical assumption test, coefficient of determination test, t-test and f-test. Based on the results of hypothesis testing, it shows that partially motivation, discipline and compensation have a significant positive effect on the performance of employees of dicv siuk body repair. Based on the f test, the variables of motivation, discipline and compensation simultaneously have a significant positive effect on employee performance at dicv siuk body repair.
Pengaruh Model Pembelajaran Think Talk Write dengan Bantuan Gambar Terhadap Hasil Belajar Bahasa Arab Siswa Kelas VIII MTs Negeri 1 Deli Serdang
Authors: Ridho Ramadhani Fitri  , Zulfahmi Lubis
Published: August 2024

The purpose of this study was to test the effect of the Think Talk Write learning model with the help of images on the learning outcomes of Arabic students in grade VIII at MTsN 1 Deli Serdang. The method used in this study is a quantitative method with experimental techniques. After the researcher conducted research and experiments on grade VIII students at MTsN 1 Deli Serdang, the researcher found that the Think Talk Write learning media with the help of images greatly influenced student learning outcomes. The increase in learning outcome test scores when using Think Talk Write learning media with the help of images. In addition, students are also more active in learning. And based on the statistical value obtained t count 1.962 and t table 2.042 Because t count <t table, then Ho is accepted. So it can be concluded that there is a significant effect of the Think Talk Write learning model on student learning outcomes. There is a significant increase in learning outcomes with an average increase of 35 after getting a learning model using Think Talk Write. The learning that is carried out becomes interesting and fun for students. Because learning hones students to think critically, collaborate, and can share opinions among students. Learning tends not to be boring. Learning objectives can also be achieved optimally.
Penerapan Pembelajaran Pendidikan Agama Islam Berbasis Multikultural di SMP Laksamana Martadinata Medan
Authors: Imam Setiawan  , Junaidi
Published: August 2024

Multicultural values have become an integral part of the culture at Laksamana Martadinata Middle School Medan. Lots of  success in cultivating and maintaining multicultural values is recognized as the result of learning Islamic Religious Education,especially for Muslim students at the school. This article uses descriptive research, which means a systematic, factual and accurate description of the facts, characteristics and relationships between the phenomena being investigated. Research shows that at Laksamana Martadinata Medan Middle School, a multicultural-based Islamic Religious Education learning approach hasbeen implemented successfully. Awareness of student diversity, both in terms of religion and culture, is the main basis for developing an inclusive learning approach. This school concretely aligns Islamic teachings with the values of multiculturalism in preparing learning materials. This material includes an understanding of tolerance, mutual respect, and celebrating religiousand cultural differences. This implementation has a positive impact on students, who become more open, understand diversity, and are able to develop inclusive attitudes.