bluuebunny/crossref_metadata_2025 huggingface dataset:
miR-539-5p inhibits proliferation and invasion of gallbladder cancer cells by targeting BACH1
Authors: Fang Jian , Zhu Huifen , Xu Pengcheng , Jiang Renya
Published: March 2022

Background: Gallbladder cancer (GBC) is a common biliary tract malignancy worldwide, with no definite molecular-targeted treatment. Previous studies have shown that miR-539-5p was observed to be aberrantly expressed in multiple tumors and was associated with the occurrence and progression of human cancers. However, the functional role and exact mechanism of miR-539-5p in GBC progression remain barely known.Methods: The expression of miR-539-5p and BACH1 in GBC tissues and cell lines was detected by qRT-PCR. Western blotting was utilized to detect the protein level of BACH1. CCK-8 assay, colony formation assay, and Transwell assay was employed to evaluate GBC cell proliferation and invasion. Dual-luciferase reporter gene assay was utilized to verify the target relationship between miR-539-5p and BTB domain and CNC homolog 1 (BACH1). Xenograft tumor experiments were conducted on nude mice to confirm antitumor effect of miR-539-5p on GBC in vivo.Results: Our results showed that miR-539-5p was downregulated in GBC tissues and cell lines. Overexpression of miR-539-5p significantly suppressed the proliferation and invasion abilities of GBC cells. Dual-luciferase reporter gene assay confirmed that BACH1 was a target gene of miR-539-5p. Moreover, knockdown of BACH1 exhibited anti-proliferation and anti-invasion effects on GBC cells. Mechanistically, miR-539-5p suppressed the malignant behaviors of GBC cells, which were largely counteracted by the overexpression of BACH1. In vivo experiments, miR-539-5p overexpression tremendously repressed GBC tumor growth.Conclusion: miR-539-5p inhibited GBC progression via directly targeting BACH1, which can be served as potential treatment targets against the progression of GBC.
Effect of thermal treatment at high temperature on phase stability and transformation of Yb2O3 and Y2O3 co-doped ZrO2 ceramics
Authors: Cao Zheng , An Shengli , Song Xiwen
Published: March 2022

Y2O3 doped ZrO2 (YSZ) ceramic material is used to protect alloy components worked in high-temperature. But its phase transformation occurred at high temperate leads to YSZ invalid. This study explored the process of phase changes of YSZ at high temperature. Besides, the phase stability and transformation details of Yb2O3 and Y2O3 co-doped ZrO2 (YbYSZ) ceramics were also discussed. The ceramic samples were synthesized using a solid-state reaction method. The results of X-ray diffraction and Raman spectra displayed that all bulks exhibited almost the same crystal structure. The phase transformation investigation through the thermal treatment at 1300 °C demonstrated that YbYSZ ceramics had better phase stability than YSZ. The content of the monoclinic phase calculated according to X-ray diffraction of ceramic samples heat-treated at 1300 °C for 0 – 358 hours showed a sigmoidal behavior. The content change of monoclinic phase of YbYSZ ceramics with heat treatment time at 1300 °C can be divided into three stages: (I) diffusion progress accompany by the transformation of t′→t+c→t+c+m, (II) drastic change from tetragonal phase to monoclinic phase, and (III) the content of monoclinic phase gets saturation.
Polarization-entangled photon pairs in the visible spectral band using intermodal spontaneous four-wave mixing
Authors: Lee Ju Han , Lee Kyungtaek , Jung Junha
Published: March 2022

The theoretical and experimental investigation results of the generation of the polarization-entangled photon pairs operating at visible wavelengths are reported. The generation of polarization-entangled photon pairs was based on intermodal spontaneous four-wave mixing (IM-SFWM) using standard step-index few-mode fiber. It was shown theoretically that several combinations of IM-SFWM processes could occur depending on spatial modes of a pump beam. A polarization-entangled photon pair source based on Sagnac loop incorporating a segment of few-mode fiber were then experimentally created. A two-photon interference fringe visibility of our implemented photon pair source were 91.7% and 88.8% in H/V bases and D/A bases, respectively. A quantum state tomography was also conducted to reconstruct the density matrix of the generated state with a fidelity to a maximum entangled state of 93.1%.
Research Polyphenylene Sulfide Fiber-Reinforced Elastic Wheel Polishing based on Soft Consolidation Abrasive
Authors: yisen zeng , xi zeng
Published: March 2022

In industry 4.0 background, traditional technical industry is mentioned more and more times. Technological innovation has been advanced in precision-machine internationally. Faced to remained peak of surface layer distributed non-uniformly, this article proposes polyphenylene sulfide fiber-reinforced method to get highly sophisticated surface. Based on different hard matrix rubber of wheels, fiber added into wheels to improve elastic modulus and guarantees abrasive particles which contacts with workpiece distributed evenly while polishing. This method reduces scratches and avoids subsurface damage when wheel polishes in declining angle. Compared to different proportional fiber, two hard wheels in 5% fiber can get smoother and parallel surface when wheel rotates in high speed. Predicted model of rubber built based on Halpin-Tsai empirical formula, which displays elastic modulus of fiber is much higher than matrix rubber and adds polyphenylene sulfide can enhance anti-truncation ability of wheel exponentially. Rubber surface layer supports soft consolidation abrasive elastically to ensure particles arranged horizontally which can be reflected from observing deformation and stress of wheel by ansys. This phenomenon called elastic support that guarantees every particle have same volume material removed on contact area to get smoother surface. In following polishing experiments, carbide surface polished by 5% fibrous elastic wheel is the best among 0%, 2% ,4% and 5% polyphenylene sulfide. Fiber-reinforced elastic wheel surely promotes carbide polished effectively.
Bodrum daki Otel İşletmelerinin Web Sitelerinin Etkinlik ve Verimlilik Bakımından Analizi (An Analysis of the Efficiency and Effectiveness of Hotel Websites in Bodrum)
Authors: Esen Özlem , Yazıcı Ayyıldız Ahu
Published: March 2022

Turistlerin tatil kararlarını vermede artan bir şekilde dijital bilgi kullanımlarına paralel olarak, bu çalışma Bodrum’daki 5 yıldızlı otellerin web sitelerini araştırmayı ve karşılaştırmayı amaçlamaktadır. Çalışma, özellikle bu otellerin web sitelerinin etkinlik ve verimlilik derecelerini araştırmayı ve belirlemeyi hedeflemektedir. Çalışmanın Bodrum’a odaklanmasının temel nedeni, Bodrum’un Time dergisi tarafından 2021 yılında tarafından “Dünyanın En Müthiş 100 Yeri” listesinde gösterilmesidir. Time dergisinin okuyucu kitlesi göz önünde bulundurulduğunda, Bodrum’a önümüzdeki ve daha sonraki sezonlarda gelecek turist sayısında önemli bir artış beklenebilir. Çalışmadaki veri seti SPSS (Statistical Package for the Social Sciences) istatistiki veri analiz paket programı kullanılarak analiz edilmiş ve otellerin web sitelerinin pazarlama iletişimi verimliliği ve etkinliğine ilişkin çeşitli frekans tabloları oluşturulmuştur. Tespit edilen bazı yaygın eksikliklerden hareketle, bölgedeki uygulayıcılara, otel sahiplerine ve yöneticilere, gelecekte web sitelerini tasarlama veya yeniden tasarlama faaliyetleri konusunda çeşitli tavsiyelerde bulunulmuştur. Araştırma, temel olarak bir tutundurma aracı olarak, otellerin web sitelerine atfettikleri önem açısından önemli farklılıklar olduğunu göstermektedir.
Tabak Prezantasyonunun Kötü Görünümlü Yiyeceklerin Kabulüne Etkisi: Şırdan Örneği (The Effect of Plate Presentation on the Acceptance of Bad-Looking Foods: Şırdan Example)
Authors: Uçuk Ceyhun , Kahraman Ayşe Gülnihal , Özdemir Sami Sonat
Published: March 2022

Bu çalışma, görünümü sebebiyle tüketimi tercih edilmeyen yemeklerin estetik değeri bulunan sunumlar yoluyla kabulünün artırılmasını ele almaktadır. Bu kapsamda kötü görünümlü yemekleri temsilen şırdan dolması, yenilikçi sunum teknikleri kullanılarak 5 farklı şekilde sunulmuştur. Sunumların değerlendirilmesi amacıyla hazırlanan anket formu, Türk tüketicilere çevrimiçi olarak iletilmiştir. Araştırma kapsamında hazırlanan 5 sunum özelinde renk, görsel doku, şekil ve genel sunum (komposizyon) parametreleri belirlenerek beğeni testi uygulanmıştır. Şırdan dolmasını görsel özelliklerinden dolayı tüketmek istemediğini ifade eden 215 katılımcıdan elde edilen veriler sonucunda, şırdan dolmasının bütün halde sunulmasının beğeni puanını olumsuz etkilediği ve şırdandan alınan kesitlerin yatay sunumunun tüm parametreler bazında daha fazla beğeni puanı aldığı tespit edilmiştir. Bunun yanı sıra şırdan dolmasına yönelik en fazla beğeni toplayan tabakların sunumları incelendiğinde, renk çeşitliliği ve canlı renk kullanımı, sos veya baharat kullanımı, şırdan dolması miktarı, tabak doluluk oranı ve tabağın odak noktasının şırdan dolması olmaması gibi unsurların etkili olduğu dikkat çekmiştir. Araştırma bulgularından hareketle, şırdan dolması ve temsil ettiği yiyeceklerin yenilikçi sunum teknikleriyle tüketici nezdinde kabul görme oranının artırılabileceğine ve görsel manipülasyonun tüketici tercihlerinde sahip olduğu etkiye yönelik önemli sonuçlara ulaşılmıştır.
COVID-19 Salgınının Otellerin Mutfak Departmanına Yansımaları: Antalya daki Beş Yıldızlı Otel İşletmeleri Üzerinde Nitel Bir Araştırma (Reflections of the COVID-19 Outbreak on the Hotel Kitchen Department: A Qualitative Research on Five-Star Hotels in Antalya)
Authors: Güneri Beysun , Yay Özlem
Published: March 2022

Bu araştırmanın amacı, Antalya'da bulunan beş yıldızlı otel işletmelerinin mutfak departmanlarının COVID-19 salgın sürecinde nasıl etkilendiklerini, mutfak şeflerinin bakış açısıyla ortaya koymaktır. Araştırmanın yöntemi nitel araştırma olup, veriler 2-18 Aralık 2021 tarihleri arasında, 20 mutfak şefi ile yüz yüze gerçekleştirilen görüşmeler doğrultusunda elde edilmiş ve içerik analizine tabi tutulmuştur. Araştırmanın sonucunda, COVID-19 salgının otellerin mutfak departmanlarına olumlu ve olumsuz yansıyan etkileri, mutfak departmanında meydana gelen değişiklikler ve değişikliklerin sürdürülebilirliğine ilişkin bulgular elde edilmiştir. Çalışmanın önemli bulgularına göre mutfak şeflerinin bir kısmı yeni uygulamaları tamamen; bir kısmı ise kısmen devam ettirmek istediklerini belirtmektedirler. Ayrıca mutfak şeflerinin bir kısmı da COVID-19 salgınının getirdiği yeni uygulamaların etkisiyle, otel işletmelerinin her şey dahil açık büfe sisteminden her şey alakart sistemine doğru dönüşüm içinde olduğunu ifade etmektedirler. Şefler yeni düzenlemelerin, kişiye özel hizmet verebilmeyi mümkün kıldığını ve her şey dahil açık büfe sisteminin iyi bir alternatifi olabileceğini belirtmişlerdir. Ancak mutfak şeflerinin bir kısmı ise, yeni uygulamalardan memnun olmayıp tamamen eski sisteme geri dönmek istemektedirler.
Sinop Şehrinin Destinasyon İmajı ve Destinasyon Bağlılığı, Tavsiye Etme ve Öznel İyi Oluş Üzerindeki Rolü (Destination Image of Sinop Province and its Role on Destination Attachment, Recommending and Subjective Well-being)
Authors: Daşkın Mustafa , Aşan Kübra
Published: March 2022

Bu çalışmanın amacı, Sinop destinasyon imajının araştırılması ve destinasyon imajının destinasyon aidiyeti, tavsiye etme davranışı ve öznel iyi oluş üzerindeki rolünü araştırmaktır. Araştırma verileri Sinop ilini ziyaret eden turistlerden yüz yüze anket tekniği ile toplanmıştır. Araştırma lokasyonunda toplam 143 adet kullanılabilir anket elde edilmiştir. Verileri test etmek için çoklu regresyon analizi kullanılmıştır. Mevcut çalışmada tüm hipotezler desteklenmiştir. Çalışma sonuçlarına göre, destinasyon imajının aidiyet ve tavsiye etme tutumlarının yanı sıra öznel iyi oluş üzerinde olumlu etkileri olduğu sonucuna ulaşılmıştır. Ancak ortalama değerler, katılımcıların DEİM6 (Alışveriş imkanları yeterlidir), DEİM7 (Gece hayatı yeterli), DEİM8 (Sinop’ta yeme-içme seçenekleri çok çeşitlidir) ve DEİM10 (Gelişmiş altyapıya sahiptir) hususlarında hemfikir olmadıklarını göstermektedir. Bu bulgular, turistlerin mevcut algılarını ve imajını anlamak ve gerekli aksiyonları hayata geçirmek açısından destinasyon için oldukça önemlidir. Araştırma öncülleri ve bulguları açısından yeni olan bu çalışma turizm literatürüne katkı sağlamakta ve turizm uygulayıcılarına da faydalı öneriler sunmaktadır.
Turizmde Çekicilik Unsuru Olarak Gastronomi Müzeleri: Adatepe Zeytinyağı Müzesi Örneği (Gastronomy Museums as Attractive Elements in Tourism: The Case of Adatepe Olive Oil Museum)
Authors: Lokman Uğur , Yarmacı Nihan , Güdül Halime
Published: March 2022

Farklı kültürlere olan ilginin mutfak açısından ele alındığı gastronomi müzeleri turizmde çekici bir unsur haline gelmiştir. Özellikle 20. yüzyılın sonlarına doğru insanların ilgisini çekmeyi başaran gastronomi müzeleri büyük bir ivme kazanmıştır. Kâr amacı olmayan kuruluşlar arasında yer alan gastronomi müzeleri, kültürel açıdan geçmişin anlaşılmasına katkı sağlamanın yanında destinasyon ve ülkelere de turizmde çekiciliği açısından değer katmaktadır. Bu bağlamda Türkiye’nin ilk zeytinyağı müzesi olan Adatepe Zeytinyağı Müzesi’nin turizmde çekicilik unsuru olarak kullanımı ve bölgenin turizm faaliyetlerine katkısının belirlenmesi amaçlanmaktadır. Araştırma kapsamında müzenin ortak kurucularından olan üç kişi ile hem yüz yüze hem de dijital ortamda görüşme yapılmıştır. Çalışmada nitel veri toplama yöntemlerinden görüşme tekniği ve gözlem kullanılmıştır. Araştırma sonuçlarına göre müzenin bulunduğu Küçükkuyu ilçesinde müze açılmadan önce turistik faaliyetlerin fazla olmadığı tespit edilmiştir. Adatepe Zeytinyağı müzesi kurulduktan sonra eğitim ve gurme turları ile beraber münferit turistik ziyaretlerin de arttığı belirlenmiştir. Araştırma sonucunda, gastronomi müzelerinin destinasyon ya da bölgenin turizm potansiyeli üzerinde olumlu bir katkısı olacağı öngörülmektedir.
Changes of high order aberrations after photorefractive keratectomy (PRK) and FemtoLASIK
Authors: Khodzhabekyan N. V. , Khandzhyan A. T. , Tarutta E. P. , Harutyunyan S. G. , Sengaeva M. D.
Published: March 2022

Purpose: a comparative study of corneal and total wavefront aberration changes after traditional PRK and FemtoLASIK.Material and methods. Corneal and total wavefront aberrations were studied on OPD-Scan III aberrometer (Nidek) in 63 patients (126 eyes) with moderate and high myopia before and after FemtoLASIK (Ziemer + Nidek-Quest, Japan) (44 patients, 88 eyes) and PRK (Nidek-Quest, Japan) (19 patients, 38 eyes). Spherical aberration (SA) was considered as the sum Z4 + Z8 + Z12.Results. The corneal asphericity coefficient Q changed to positive values after both types of intervention. Corneal RMS HOA increased in both Femto and PRK groups. Corneal Tilt 1 increased after FemtoLASIK and moved to negative values after PRK, corneal tilt 2 moved to negative values after Femto and to positive values after PRK. The vertical trefoil showed no significant change in the Femto group and dropped in the PRK group. The vertical and horizontal coma (coma 7, coma 8) changed synchronously. Corneal SA increased after Femtolasic, and became negative after PRK. The total aberrations showed a lesser change and the changes were not synchronized with the corneal ones: in particular, the RMS HOA fell from 0.28 ± 0.05 to 0.19 ± 0.05 in the Femto group, while the corneal RMS increased significantly. In the PRK group, the corneal RMS HOA showed some increase, but it was much less than corneal RMS: from 0.25 ± 0.07 to 0.62 ± 0.02 μm. The total SA increased from 0.11±0.03 to 0.27±0.02 in the Femto group and showed an insignificant drop from 0.09±0.03 to 0.03 ± 0.01, while remaining positive in the PRK group.Conclusions. The changes of the wavefront after FemtoLASIK and PRK are both significant and different. The revealed differences in the changes of corneal aberrations correspond to different profiles of the anterior surface of the cornea formed after FemtoLASIC and PRK. The internal optics of the eye partially compensates the corneal aberrations induced by excimer laser surgery.
Global Trends and Effects of Fiscal Policy in 2021
Authors: Bukina I. S.
Published: March 2022

The coronavirus pandemic in 2020 had a negative impact on the state of the Russian economy and the consolidated budget of the Russian Federation. At the same time, the budgetary system of the Russian Federation is sufficiently resilient to such external shocks. In 2020, borrowed funds from the domestic market were used to finance the budget deficit, partly from the Sovereign Fund, the amount of which, however, did not change by the beginning of 2021. Despite the spread of new strains of coronavirus infection and the relatively low level of vaccination in Russia, the recovery of the global economy and rising commodity prices contributed to a significant increase in consolidated budget revenues. At the same time, a policy of budget consolidation was pursued – those items of federal budget expenditures that unexpectedly increased in 2020 (primarily healthcare spending) were subject to reductions. The beginning of 2022 was marked by the emergence of new external shocks that significantly destabilize the economic and financial sphere of Russia. Now a certain level of budgetary stability has been achieved, which, among other things, will make it possible to solve new targets of the population and businesses support, but this is not enough in the medium term. Directions for operational measures of fiscal policy to restore the sustainability of public finances in the current environment are proposed.
Measures to Neutralize the Consequences of Sanctions Against Russia at the Federal and Regional Levels
Authors: Alikhani S.
Published: March 2022

The Russian ruble depreciated sharply in 2014 after the US embargo was imposed, in just one day it lost 19% of its value, which was the biggest daily drop in the previous 16 years. Inflation has reached a three-year high. The reasons for the sharp decline in the indicators of the Russian economy were the factors of a sharp drop in oil prices, sanctions against the country and insufficient effective management. The article discusses Russia’s anti-sanctions actions at the federal and regional levels of government. It is concluded that the following measures have become the most effective in responding to sanctions: the introduction of import sanctions against countries subject to the embargo, reducing dependence on the dollar and euro in foreign trade (de-dollarization) by concluding bilateral currency agreements, changing export directions, introducing a national payment system, adopting import substitution plans within federal and regional policies, as well as a plan to support firms affected by sanctions. It is noted that the sanctions posed threats not only to the economy of Russia and its regions, but also to the economies of European countries and, ultimately, to the stability of the global financial system.
Histological Manifestations of Diabetic Kidney Disease and its Relationship
with Insulin Resistance
Authors: Adeva-Andany María M. , Adeva-Contreras Lucía , Fernández-Fernández Carlos , Carneiro-Freire Natalia , Domínguez-Montero Alberto
Published: March 2022

Histological manifestations of diabetic kidney disease (DKD) include mesangiolysis,
mesangial matrix expansion, mesangial cell proliferation, thickening of the glomerular basement
membrane, podocyte loss, foot process effacement, and hyalinosis of the glomerular arterioles, interstitial
fibrosis, and tubular atrophy. Glomerulomegaly is a typical finding. Histological features
of DKD may occur in the absence of clinical manifestations, having been documented in patients
with normal urinary albumin excretion and normal glomerular filtration rate. Furthermore, the histological
picture progresses over time, while clinical data may remain normal. Conversely, histological
lesions of DKD improve with metabolic normalization following effective pancreas transplantation.
Insulin resistance has been associated with the clinical manifestations of DKD
(nephromegaly, glomerular hyperfiltration, albuminuria, and kidney failure). Likewise, insulin resistance
may underlie the histological manifestations of DKD. Morphological changes of DKD are
absent in newly diagnosed type 1 diabetes patients (with no insulin resistance) but appear afterward
when insulin resistance develops. In contrast, structural lesions of DKD are typically present before
the clinical diagnosis of type 2 diabetes. Several heterogeneous conditions that share the occurrence
of insulin resistance, such as aging, obesity, acromegaly, lipodystrophy, cystic fibrosis,
insulin receptor dysfunction, and Alström syndrome, also share both clinical and structural manifestations
of kidney disease, including glomerulomegaly and other features of DKD, focal segmental
glomerulosclerosis, and C3 glomerulopathy, which might be ascribed to the reduction in the
synthesis of factor H binding sites (such as heparan sulfate) that leads to uncontrolled complement
activation. Alström syndrome patients show systemic interstitial fibrosis markedly similar to that
present in diabetes.
Inferior Vena Cava Agenesis Associated with Urogenital Anomalies: A
Case Report
Authors: Atay Musa , Kocakoc Ercan
Published: March 2022

Background:

Inferior vena cava (IVC) agenesis, ectopic ureterocele, and ureteral duplication
are very rare congenital anomalies.

Case Presentation:

A-25-year-old female patient was referred with right flank pain, chills and dysuria.
Laboratory tests and CT showed findings consistent with acute pyelonephritis. The medical history
revealed only frequent urinary tract infections and Factor V Leiden mutation. The patient was treated
with antibiotherapy. CT examination demonstrated IVC agenesis (IVCA). Urogenital anomalies such
as vaginal ectopic ureterocele, ureteral duplication and septate uterine anomaly were also present.

Conclusion:

We report the first occurrence of IVC agenesis associated with multiple urogenital anomalies
in the literature.
An Electronic Evaluation of Symptoms in People of India Post-COVID-19
Vaccination
Authors: Kamboj Sweta , Kamboj Rohit , Kamboj Shikha , Dutt Rohit , Guarve Kumar , Bansal Kamal , Rohila Vivek
Published: March 2022

Background:

Remarkable and groundbreaking performances of scientists all over the
globe have led to the evolution of COVID-19 vaccines, which are extensively viewed as means to
control the epidemic. The primary purpose of this research work was to discover the major side effects
of the vaccines, mainly in Homo sapiens.

Methods:

An online survey was conducted in various cities of Haryana, India, using a trial version
of QualtricsCoreXM software to prototype 20 questionnaires.

Result:

In the survey, 200 candidates participated, among which 83.5% had received Covishield
and 16.5% had been vaccinated with Covaxin. Overall 65% of respondents have reported side effects.
The major side effects reported were fever, tiredness, myalgia, diarrhea, headache, etc.

Conclusion:

Succeeding the survey related to the effects of COVID-19 vaccine on non-identical
Homo sapiens, generally with respect to their perspective regarding the symptoms of vaccine, both
the vaccines were found to have mild side effects which could be easily managed.
Formulation, Characterization, and Pharmacokinetic Evaluation of Novel
Glipizide-phospholipid Nano-complexes with Improved Solubility and
Bio-availability
Authors: Rathor Sandeep , Bhatt Dinesh Chandra
Published: March 2022

Background:

The proposed study was aimed to formulate and evaluate the Glipizide-Phospholipid Nano-complex. Since Glipizide is a poorly soluble drug, its complexation with phospholipids is an ideal approach to improving solubility

Method:

To improve the oral potency of Glipizide, its phospholipid complex was prepared by employing the solvent evaporation method. The formulations were characterized using DSC, FT-IR, PXRD, SEM, TEM, and hot stage microscopy (HSM). Solubility tests of the Glipizide-Phospholipid Nano-complex revealed a significant increase in aqueous solubility compared to Glipizide's physical combination. The oral bioavailability of the Glipizide-Phospholipid Nano-complex was measured by using HPLC in Wistar rats’ plasma. FTIR and PXRD results revealed no significant interaction between the drug and the phospholipid in the formulation. SEM and TEM studies confirmed the morphology of the formulation assuring the conversion of crystalline form into an amorphous structure.

Results:

The Glipizide-Phospholipid Nano-complex had a greater peak plasma concentration (5.2 vs 3.8 g/mL), a larger AUC (26.31 vs 19.55 μgh/L), and a longer T1/2 (2.1 vs 4.1 h) than free Glipizide, indicating that it improved drug dissolution rate.

Conclusion:

The outcomes suggested that a phospholipid complexation is a potential approach to increasing water-insoluble drugs' oral bioavailability.
Структура, диэлектрические и сегнетоэлектрические свойства тонких пленок мультиферроика Ba-=SUB=-2-=/SUB=-NdFeNb-=SUB=-4-=/SUB=-O-=SUB=-15-=/SUB=-
Authors: Павленко А.В. , Ильина Т.С. , Киселев Д.А. , Стрюков Д.В. , Очкуров М.В.
Published: March 2022

С использованием рентгендифракционного анализа, диэлектрической спектроскопии, методов анализа сегнетоэлектрических свойств и сканирующей зондовой микроскопии исследованы фазовый состав, наноструктура и свойства тонких пленок мультиферроика Ba2NdFeNb4O15. Для роста пленок на поверхности монокристаллической подложки Pt/MgO(001) использовался одностадийный метод ВЧ-катодного распыления в атмосфере кислорода. Установлено, что полученные пленки Ba2NdFeNb4O15 являются однофазными, беспримесными и с-ориентированными, что позволило изучить их диэлектрические свойства вдоль полярного направления. В пленках имели место деформации растяжения элементарной ячейки 1.35% вдоль полярной оси), что привело к реализации в пленке Ba2NdFeNb4O15 сегнетоэлектрической фазы при комнатной температуре. Обсуждаются причины выявленных закономерностей и перспективы использования данного материала в виде наноразмерных тонких пленок. Ключевые слова: мультиферроик, диэлектрические характеристики, сегнетоэлектрик, тетрагональная вольфрамовая бронза.
Широкополосная ЭПР-спектроскопия кристалла Y-=SUB=-3-=/SUB=-Al-=SUB=-5-=/SUB=-O-=SUB=-12-=/SUB=-:Ho-=SUP=-3+-=/SUP=-
Authors: Асатрян Г.Р. , Шакуров Г.С. , Петросян А.Г. , Крамущенко Д.Д. , Ованесян К.Л.
Published: March 2022

EPR spectra of Ho3+ impurity ions were recorded in single crystals of yttrium aluminum garnet (Y3Al5O12) in the frequency range of 114-170 GHz, at a temperature of 4.2 K. The measurement results indicate the substitution of Ho3+ ions for Y3+ ions in the dodecahedral position with D2 local symmetry. The magnitude of the g-factor, the hyperfine structure constant, and the energy interval between the main and the first excited nondegenerate sublevels of the main multiplet 5I8 are determined. Weak satellite signals have also been registered, the origin of which is associated with the formation of antisite defects in the environment of Ho3+ paramagnetic centers.
Влияние скорости деформации на эффект пластификации ультрамелкозернистого сплава Al-Cu-Zr в высокопрочном состоянии
Authors: Садыков Д.И. , Орлова Т.С. , Мурашкин М.Ю.
Published: March 2022

Исследовалось влияние скорости деформации на эффект пластификации (ЭП) ультрамелкозернистого (УМЗ) сплава Al-1.47Cu-0.34Zr (wt%), структурированного методом интенсивной пластической деформации кручением. Значительное увеличение пластичности (более чем в 2 раза) при сохранении высокого уровня прочности (предел прочности ~465 MPa) в УМЗ-сплаве было достигнуто в результате дополнительной деформационно-термической обработки (ДТО), состоящей из низкотемпературного отжига и небольшой дополнительной деформации. Показано, что ЭП после ДТО сохраняется при изменении скорости деформации от 10-4 до 10-3 s-1 и уменьшается вдвое при дальнейшем ее увеличении до 10-2 s-1. Определен коэффициент скоростной чувствительности для УМЗ-сплава Al-1.47Cu-0.34Zr (wt%) в состояниях до и после ДТО. Обсуждаются возможные причины подавления ЭП при высоких скоростях деформации (≥ 10-2 s-1). Ключевые слова: алюминиевые сплавы, интенсивная пластическая деформация, ультрамелкозернистая структура, прочность, пластичность, скоростная чувствительность.
Vom Rechtstext zum regelkonformen Geschäftsprozess
Authors: Niemand Sven
Published: March 2022

Im täglichen Betrieb von Organisationen ist Compliance gleichermaßen herausfordernd wie unerlässlich. Nicht zuletzt steht das Compliance-Management vor der schwierigen Aufgabe, alle Tätigkeiten und Abläufe
innerhalb der Organisation – die Geschäftsprozesse – regelkonform zu gestalten und im Hinblick auf Regelkonformität zu überwachen. Häufig könnte Geschäftsprozessmanagement bei der Implementierung von Compliance
helfen, da es bereits etablierte Techniken zum Gestalten und Überwachen von Geschäftsprozessen mitbringt. Hohe Komplexität im Recht, juristische Fachsprache und unterschiedliche Ideologien lassen aber auch die
Zusammenarbeit von Experten im Compliance- und Geschäftsprozessmanagement zu einer besonderen Herausforderung werden. Vor allem bildet die interdisziplinäre Kommunikation zwischen den Juristen im Compliance-Management
und den juristischen Laien im Geschäftsprozessmanagement eine Barriere.
Als zentrales Brückenelement zwischen Compliance- und Geschäftsprozessmanagement wird in dieser Arbeit das Konzept der regelbasierten Prozessmodelle eingeführt. Dahinter verbirgt sich die Idee, die regulatorischen
Anforderungen in Form von Prozessmodellen zu visualisieren – also in einem für das Geschäftsprozessmanagement üblichen Dokumentationsformat. Mit diesen speziellen Prozessmodellen kann die Kommunikation zwischen
Rechtsexperten und juristischen Laien unterstützt werden, indem der Einsatz von Rechtstexten und juristischer Fachsprache reduziert und eine gemeinsame Kommunikationsbasis geschaffen wird.
Doings of Caste: An Analysis of Inter-Caste Violence among Dalits in Bama’s Novel, Vanmam: Vendetta
Authors: Kumar Dr. Brijesh
Published: March 2022

Caste carries a sort of symbolic value. For those who are at the top in the hierarchical Indian caste system have positive symbolic value of caste and those who remain in the bottom have negative value of it. It is so infectious that everyone in this system wants to assert his supremacy over the next one and this hierarchy goes on till the lowest of the low. Dalits are no exception to this rule. Dalits as a community has been victims of caste-based atrocities since the inception of caste-system but they do not hesitate to apply the same sort of caste rules among themselves. Having been beguiled by the Brahmanical ideologies, Dalits have divided themselves into many castes on the basis of high and low. By doing so, they have unknowingly reinforced their own torture in the hands of their oppressors. Bama is a prolific Dalit writer who has touched upon this very sensitive issue of inter-caste violence among Dalits in her third novel, Vanmam: Vendetta. In the novel, she has underscored how Dalits fight among themselves in the name of high and low caste falling prey to the ideologies of their oppressors. In this researcher paper, a genuine effort has been made to highlight how castebecomes functional in promoting inter caste violence among people of two Dalit castes in a village of Tamilnadu.
NEW VISUAL RECORDS OF PLANTS CONSUMED BY 10 LIZARD SPECIES ON ISLANDS OF THE GULF OF CALIFORNIA, AND IMPLICATIONS FOR THE INSULAR ECOLOGY AND TROPHIC WEBS
Authors: Cerdá-Ardura Adrián
Published: March 2022

II present an unpublished list of 59 plant species of 19 families that constitute a source of food for the insular reptiles Ctenosaura conspicuosa, C. hemilopha, Sauromalus varius, S. hispidus, S. slevini, S. klauberi, S. ater, Dipsosaurus dorsalis, D. catalinensis, and Petrosaurus thalassinus on 15 islands of the Gulf of California based on 711 direct observations of feeding events. Two reptile species climb to the tops of cardon cacti branches to purposely eat flowers and fruits and accidentally dislodge plant parts that partially subsidize ground organisms; the rest forage mainly on the ground, but do show a strong evolutionary, ecological, and behavioral tendency to climb on low trees and bushes to eat leaves and flowers. The reptiles’ food habits influence other populations, species, trophic levels, and even the whole insular communities, both up (to predators), down (to producers and primary consumers) and horizontally (to competitors). Insular herbivorous and omnivorous lizards, as primary and secondary consumers, and even as predators, are in the middle of complex food webs. In these interactions, the cardon cactus provides vast amounts of biomass and energy to the whole insular communities.
DEPREDACIÓN DE LA LAGARTIJA Aspidoscelis communis (Teiidae) POR LA SERPIENTE BEJUQUILLO Oxybelis microphtalmus (Colubridae) EN MICHOACÁN, MÉXICO
Authors: Bucio Jiménez Luis Eduardo , Flores Loyola Claudia Mónica
Published: March 2022

Reportamos la observación de una serpiente bejuquillo Oxybelis microphtalmus depredando una lagartija Aspidoscelis communis. A pesar de que existe bastante información acerca de la dieta de O. microphtalmus, este es el primer registro de depredación de A. communis. Esta información es importante para conocer más sobre la dieta del género Oxybelis.
EL CANTO DE ANUNCIO DEL ANURO MÁS PEQUEÑO DE MÉXICO, LA RANA PIGMEA Craugastor pygmaeus (ANURA: CRAUGASTORIDAE)
Authors: Reyna Bustos Oscar Francisco , Serrano José Manuel , Huerta Francisco Martín
Published: March 2022

Craugastor pygmaeus es el anuro más pequeño dentro de su género y probablemente el anuro más pequeño conocido en México. En el presente estudio se describe el canto de anuncio de la rana C. pygmaeus de una población localizada en una localidad de La Ciénega dentro del Área de Protección de Flora y Fauna Sierra de Quila, Jalisco, México. El canto consiste en un silbido corto sin frecuencia modulada con una repetición sumamente irregular en el tiempo. Se distinguió que los cantos de anuncio presentan variación restringida en la frecuencia dominante, lo cual sugiere que C. pygmaeus cuenta con una firma espectral distintiva a nivel individual.
HERPETOFAUNISTIC DIVERSITY IN THE ECOLOGICAL PARK "LA JOYA–LA BARRETA", QUERÉTARO, MÉXICO: A COMPARISON BETWEEN TWO SAMPLING METHODS AND VEGETATION TYPES.
Authors: Tepos Ramírez Mauricio , Pineda López Ruben , Domínguez Vega Hublester
Published: March 2022

Due to its topographic and climatic diversity, the state of Querétaro possesses high levels of amphibian and reptile richness, abundance, and endemism. However, this information must be updated constantly as regions with previously little to no information are further explored, using sampling methods that allow efficient recording of biological diversity. The objective of this study was to compare herpetofaunistic diversity among three different vegetation types (oak–forest, grassland, and associated secondary vegetation) using two sampling methods (pitfall/funnel traps and transects). We registered thirteen species: five amphibians, and eight reptiles. We found differences in species dominancy with amphibians showing higher values of relative abundance in oak forest and grassland for both sampling methods. Transects showed a higher effective number of species for q0, q1, and q2. The oak forest and secondary vegetation possess comparable similarity percentages and did not show significant differences (p = 0.54). We observed significant differences between the grassland and secondary vegetation (p = 0.02). We found high distinctness levels (> 70%) between sampling techniques. The present study shows the importance of protected natural areas as shelters for threatened groups such as amphibians and reptiles, and highlights the importance of using complementary sampling methods.
A NEW SPECIES PREVIOUSLY CONFUSED WITH Caecilia pachynema (GÜNTHER, 1859) (AMPHIBIA: GYMNOPHIONA: CAECILIIDAE) FROM THE CORDILLERA CENTRAL OF COLOMBIA
Authors: Fernandez Juan David , Lynch John D.
Published: March 2022

Caecilia pachynema is a distinctively colored species known from western Ecuador and supposedly from a remote population in the northern Cordillera Central of Colombia. Previously it had been detected that the Colombian populations of "C. pachynema’’ were likely an undescribed species. Material gathered over the past twenty years allows us to describe this new species and restrict the known distribution of C. pachynema to Ecuador.
Review Paper on LoRa based technologies for Vehicular and Tracking applications
Authors: Prajwal C Y , K S Chandan , Prajwal M S Poorna , S Likith , B Santhosh
Published: March 2022

Abstract: LoRa stands For Long Range. It is a low powered wide area network derived from chirp spread spectrum technology and encodes information through chirp pulses on to the radio waves. The range of LoRa greatly varies from few meters to approximately 100 Kilometers depending on the mode of operation. The main advantage of LoRa against Bluetooth, WiFi and ZigBee is its long range and it is well suited for transmission of small chunks of data with low bit rates. LoRa is generally operated at 915MHz, 868MHz and 433MHz which are Sub-Giga Heartz bands. These are a part of the ISM bands which are reserved for Industrial and Medical Purposes Internationally which are free of cost and do not require any kind of licensing. Vehicular communication is a form of exchanging messages between various vehicular and roadside units regarding their location, speed and much more. The LoRa technology when integrated with Vehicular Communication establishment of green corridors for Emergency vehicles by clearing the traffic and help in reaching the destination with minimal time delay. Keywords: LoRa, ISM Bands, Vehicular Communication
Multi Cloud Data Hosting with SIC Architecture
Authors: Munde Amit V. , Deshmukh Dr. Pranjali P.
Published: March 2022

Abstract: Data hosting on cloud decreases cost of IT maintenance and data reliability get enhance. Nowadays, customers can store their data on single cloud, which has some drawbacks. First is vendor lock in problem and second is security on cloud. The solution to this problem is to store the data on different cloud server without redundancy using encryption algorithm. Customers do not want to lose their sensitive data on cloud. Another issue of cloud computing is data thievery should be overcome to supply higher service. Multi-cloud environment has ability to scale back security risks. To avoid security risk we offer framework. Keywords: Cloud computing, cloud storage, data hosting, data intrusion, multi-cloud, single cloud.
Unknown Soldier of Fortune for the Professional Development of Students: Sri Dantuluri Narayana Raju
Authors: Koteswari Dr S. , Kumar B. Nandan
Published: March 2022

Abstract: Dantuluri Narayana Raju College (DNR) was founded in 1945, before Indian independence, and was an offshoot of the national movement and Renaissance thought. Being agrarian, the Godavari region had been kept away from higher academic activities during the pre-independence period. Sri Dantuluri Narayana Raju, a freedom fighter, activist and visionary wanted to provide the uneducated rural masses with the hitherto unthinkable and inaccessible source for their general development and welfare, namely higher education. This visionary, with the help of a limited number of lieutenants and committed philanthropists, worked hard with missionary zeal and brought about the establishment of a boarding school in Bhimavaram, known as West Godavari Bhimavaram (W.G.B) College in 1945.In 1964 it was renamed as Dantuluri Narayana Raju (D.N.R) College in memory of its founder. The introduction of post graduate courses in 1971 is a milestone in the history of the college. The infrastructure available in the college became an impetus for starting an Engineering College in 1980. In view of the outstanding academic excellence maintained by the college since its inception, the college was conferred autonomy in the year 1987, by the University grants commission, India. Consequently, the college has academic freedom to introduce new courses. Keyword: Dantuluri Narayana Raju College (DNR), Bhimavaram, Higher Education, West Godavari Bhimavaram (W.G.B)
Baraq Khan’s Ulus: Some Issues of Localization of his Pastures in Light of Written Sources
Authors:   Institute for Humanitarian Research ABDI, Uskenbay Kanat Z.
Published: March 2022

Objective: The purpose of the article is an attempt to determine the appro­ximate boundaries of Baraq Khan’s nomads’ territories, to summarize information from various written sources and modern literature, and to determine how the name of this famous ruler should actually be written. Research materials: To achieve this goal, we used medieval Muslim written sources. Among these sources, we have identified four groups based on language. The first group is written in Arabic. It is represented by one source – the work of al-Aini “Iqd al-juman”. The second group is more plentiful: here we drew on the data of Samarkandi’s “Matla ‘as-sa’dain”, Hafiz-i Abru’s “Zubdat at-tavarih”, Mirkhond’s “Rauzat al-safa”, and also Ibn Ruzbihan’s “Mihaman name-yi Bukhara”. The third group includes works in the Turkic language, among them Ötemish Haji’s “Kara Tavarih”, Qyrymi’s “Umdet al-Akhbar”, and Qadyrgali’s “Jami at-tavarih”. Another group of sources is written in Russian; these are the data of the chronicles and materials of the Ambassadorial Department of the Russian state. In addition to these sources, we used numismatic data and that from the letter of the Golden Horde Khan, Ulugh-Muhammad, to the Turkish Sultan Murad I. Results and novelty of the research: According to al-Aini, the lands of Baraq Khan bordered on the lands of Amir Temir. The materials of the Ambassadorial Department drew a direct continuity between the ulus of Baraq Khan and the khanate of the Qazaqs. Persian chroniclers called Baraq Khan the ruler of the Uzbek Ulus whose territory was contingent with the Qazaq Ulus that arose later. Ötemish Haji and Qyrymi call Baraq Khan’s property the “Qazaq summer pasture”. The same lands were called Uzbekiya in the work of Qadyrgali. Coins of Baraq Khan do not clarify his main possessions but nevertheless indirectly refer to the fact that the main territory of his nomads was the steppes east of the Volga. All this information has led to several important conclusions. The main conclusion is that the Baraq Khan’s ulus was located in the eastern part of the Jochid Ulus, mainly in the left-bank area of the Volga region, on the Ural and Emba rivers, and in the northern Aral and Syr Darya regions. Baraq Khan did not pursue the goal of annexing these lands to his possessions. Geographically, the lands of his ulus were contingent with the lands of the future Qazaq Khanate, founded by his son, Zhanibek. Russian and Nogai contemporaries of the Qazaqs perceived them precisely as the heirs of Baraq Khan and his grandfather Urus Khan. That last fact testifies to the continuity of not only the dynasty, but also the territories. In conclusion, the etymology of the name Baraq, which is a common Turkic anthroponym, is considered while attempts to establish Arabic roots for it are ruled out as erroneous.
Metode AHP Dan SAW Dalam Penentuan Penutupan Ruas Jalan Sebagai Upaya Pencegahan Penyebaran Covid-19
Authors: Sarjono Sandi Probo , Istiadi Istiadi , Marisa Fitri
Published: March 2022

The President of the Republic of Indonesia issued Presidential Decree Number 7 of 2020 concerning the Task Force for the Acceleration of Handling of Corona Virus Desease 2019. This decision was followed up by all Regional Leaders as the basis for the formation of a Regional Level Task Force, one of which is Malang Regency, East Java Province. One of the efforts is to implement Physical Distancing at the sub-district level, namely by closing existing roads in Malang Regency with the aim of reducing the activity of people and vehicles on these roads. The problem is how to determine the most appropriate road sections to be closed so that the policy is right on target. The decision support system application and the calculation of data obtained using the Simple Additive Weighting (SAW) and Analytical Hierarchy Process (AHP) methods can help make decisions in determining which roads will be closed. The application of these two methods is able to analyze data and provide accurate calculation results so that it can provide appropriate alternative solutions. There are differences in the results of calculations and rankings in the two methods, each method provides a value that can be used as an alternative as a choice of roads to be closed as needed.
SIMULASI PENERAPAN TEKNOLOGI FACE RECOGNITION PADA APLIKASI PENDATAAN KEHADIRAN KARYAWAN / KARYAWATI TERINTEGRASI E-MON SISTEM PENGGAJIAN DENGAN PENDEKATAN EIGENFACE DAN UXD LARAVEL VERSI 5.6 BERBASIS CLOUD SERVICE
Authors: Suharyanti Suharyanti , Rimbawan Raditya
Published: March 2022

Face recognition is a face-oriented recognition method by comparing patterns that have previously been stored in the database. In general, facial image recognition systems are divided into two types, namely feature based systems and image based systems. To carry out facial image recognition, there are several kinds of approach algorithms that can support the processing of the face image. One approach algorithm that is well known and capable of processing images with a good level of accuracy is the eigenface approach. By using the eigenface approach, the face image will be processed by performing a matrix calculation, which results in an eucludian distance to be able to get the suitability of the face image. so this research produces a result which includes: the results of the test on the FGD Functional says for the accepted percentage is: 73% for not accepted is 27%, for Non-Functional FGD says for the accepted percentage is 82% and not accepted is 18 %, and for the results of testing the adaptation of ISO 9126 in the good category with a percentage result of 79%, and the last test result, namely the Blackbox Testing test to be accepted is 83% and for the results the percentage that is not accepted is 17%
The Level Of Use And Acceptance Towards Online Learning In Covid-19 Pandemic (Case Study Of College Students In Pontianak)
Authors: Yosita Melya , Aisyah Aisyah , Pratiwi Windi
Published: March 2022

This research to determine the perceptions of college students in Pontianak City on the level of adoption, use and acceptance of online learning during the COVID-19 pandemic. This research is a descriptive quantitative using non-probability sampling with purposive sampling and quota sampling techniques. The sample of this research is college students in Pontianak City with 180 respondents. The data analysis technique used is descriptive analysis with a focus on the elements of the average. The results showed the respondents 'responses regarding Attitude, Affect and Motivation towards online learning when the Covid-19 epidemic obtained the highest index value of 153, included in the high category, respondents' responses regarding Perceived Behavioral Control obtained an index value of 145.5 also included in the high category. Meanwhile, the respondents' responses regarding Perceived Behavioral Control have an index value of 120.5 in the medium category. The conclusion of research is that college students in Pontianak City prefer face-to-face learning activities compared to online learning. The ease of use of the online education platform and the acquisition of higher scores were also felt by students when participating in online learning. The majority of university students in Pontianak are still not satisfied with online learning