bluuebunny/crossref_metadata_2025 huggingface dataset:
Neural Network as a Tool for Design of Amorphous Metal Alloys with Desired Elastoplastic Properties
Authors: Galimzyanov Bulat N. , Doronina Maria A. , Mokshin Anatolii V.
Published: April 2023

The development and implementation of the methods for designing amorphous metal alloys with desired mechanical properties is one of the most promising areas of modern materials science. Here, the machine learning methods appear to be a suitable complement to empirical methods related to the synthesis and testing of amorphous alloys of various compositions. In the present work, a method is proposed a method to determine amorphous metal alloys with mechanical properties closest to those required. More than 50,000 amorphous alloys of different compositions have been considered, and the Young’s modulus E and the yield strength σy have been evaluated for them by the machine learning model trained on the fundamental physical properties of the chemical elements. Statistical treatment of the obtained results reveals that the fundamental physical properties of the chemical element with the largest mass fraction are the most significant factors, whose values correlate with the values of the mechanical properties of the alloys, in which this element is involved. It is shown that the values of the Young’s modulus E and the yield strength σy are higher for amorphous alloys based on Cr, Fe, Co, Ni, Nb, Mo and W formed by the addition of semimetals (e.g., Be, B, Al, Sn), nonmetals (e.g., Si and P) and lanthanides (e.g., La and Gd) than for alloys of other compositions. Increasing the number of components in alloy from 2 to 7 and changing the mass fraction of chemical elements has no significantly impact on the strength characteristics E and σy. Amorphous metal alloys with the most improved mechanical properties have been identified. In particular, such extremely high-strength alloys include Cr80B20 (among binary), Mo60B20W20 (among ternary) and Cr40B20Nb10Pd10Ta10Si10 (among multicomponent).
Enhanced Magnetic Properties and Thermal Conductivity of FeSiCr Soft Magnetic Composite with Al2O3 Insulation Layer Prepared by Sol-Gel Process
Authors: Xie Qintian , Yu Hongya , Yuan Han , Han Guangze , Chen Xi , Liu Zhongwu
Published: April 2023

FeSiCr soft magnetic composites (SMCs) were fabricated by the sol-gel method, and an Al2O3/resin composite layer was employed as the insulation coating. By the decomposition of boehmite (AlOOH) gel into Al2O3 in the temperature range of 606–707 °C, a uniform Al2O3 layer could be formed on the FeSiCr powder surface. The Al2O3 insulation coating not only effectively reduced the core loss, increased the resistivity, and improved the quality factor, but it also increased the thermal conductivity of SMCs. The best overall properties with saturation magnetization Ms = 188 emu/g, effective permeability μe = 39, resistivity ρ = 8.28 × 105 Ω·cm, quality factor Q = 94 at 1 MHz, and core loss = 1173 mW/cm3 at 200 kHz and 50 mT were obtained when the SMC was prepared with powders coated by 0.5 wt.% Al2O3 and resin. The optimized SMC exhibited the lowest core loss with 27% reduction compared to the resin only-insulated sample and 71% reduction compared to the sample without insulation treatment. Importantly, the thermal conductivity of the SMCs is 5.3 W/m·K at room temperature, which is higher than that of the samples prepared by phosphating and SiO2 coating owing to the presence of a high thermal conductive Al2O3 layer. The high thermal conductivity is beneficial to enhancing the high temperature performance, lifetime, and reliability of SMCs. This work is expected to be a valuable reference for the design and fabrication of SMCs to be applied in high-temperature and high-frequency environments.
Role of TiO2 Nanoparticles in Wet Friction and Wear Properties of PEO Coatings Developed on Pure Titanium
Authors: Molaei Maryam , Fattah-Alhosseini Arash , Nouri Meisam , Kaseem Mosab
Published: April 2023

The present study aims to explain how the incorporation of anatase TiO2 nanoparticles at three different concentrations, i.e., 1, 3, and 5 g/L, into the ceramic-like oxide plasma electrolytic oxidation (PEO) coatings on pure titanium substrate can affect the friction and wear behavior of the coatings in simulated body fluid (SBF) aqueous solution. For this purpose, a ball-on-disk friction and wear tester was utilized to characterize the wear performance of the PEO coatings. The morphology and dimensions (width and depth) of wear tracks were analyzed by scanning electron microscopy (SEM) and 2D depth profilometry, respectively. The results indicated that abrasive wear was identified in all PEO coatings; however, the coefficient of friction (COF), wear volume loss, and wear rate were strongly affected by the concentration of TiO2 nanoparticles. The coatings containing TiO2 nanoparticles presented a lower COF, less wear volume loss, reduced wear rate, and improved wear resistance due to having smoother surfaces and the presence of hard TiO2 nanoparticles on their surfaces and inside the pores. The coating with 3 g/L of TiO2 nanoparticles demonstrated the lowest wear rate value of 1.33 × 10−6 mm3/Nm (about a 32% reduction compared with that of coating without TiO2 nanoparticles) and the best wear protection properties among all coatings under investigation. The findings suggest TiO2 nanoparticles incorporated PEO coatings as a promising choice of surface treatment wherein the load-bearing capacity of titanium implants is critical.
An In-Situ Tester for Extracting Piezoresistive Coefficients
Authors: Li Fengyang , Yu Runze , Zhang Dacheng
Published: April 2023

In this study, an electrostatic force-driven on-chip tester consisting of a mass with four guided cantilever beams was employed to extract the process-related bending stiffness and piezoresistive coefficient in-situ for the first time. The tester was manufactured using the standard bulk silicon piezoresistance process of Peking University, and was tested on-chip without additional handling. In order to reduce the deviation from process effects, the process-related bending stiffness was first extracted as an intermediate value, namely, 3590.74 N/m, which is 1.66% lower than the theoretical value. Then, the value was used to extract the piezoresistive coefficient using a finite element method (FEM) simulation. The extracted piezoresistive coefficient was 9.851 × 10−10 Pa−1, which essentially matched the average piezoresistive coefficient of the computational model based on the doping profile we first proposed. Compared with traditional extraction methods, such as the four-point bending method, this test method is on-chip, achieving automatic loading and precise control of the driving force, so it has high reliability and repeatability. Because the tester is manufactured together with the MEMS device, it has the potential to be used for process quality evaluation and monitoring on MEMS sensor production lines.
Numerical Investigation of Transient Breakdown Voltage Enhancement in SOI LDMOS by Using a Step P-Type Doping Buried Layer
Authors: Yang Xiaoming , Cao Taiqiang , Zhang Xiaohua , Li Tianqian , Luo Hang
Published: April 2023

In this paper, the transient breakdown voltage (TrBV) of a silicon-on-insulator (SOI) laterally diffused metal-oxide-semiconductor (LDMOS) device was increased by introducing a step P-type doping buried layer (SPBL) below the buried oxide (BOX). Device simulation software MEDICI 0.13.2 was used to investigate the electrical characteristics of the new devices. When the device was turned off, the SPBL could enhance the reduced surface field (RESURF) effect and modulate the lateral electric field in the drift region to ensure that the surface electric field was evenly distributed, thus increasing the lateral breakdown voltage (BVlat). The enhancement of the RESURF effect while maintaining a high doping concentration in the drift region (Nd) in the SPBL SOI LDMOS resulted in a reduction in the substrate doping concentration (Psub) and an expansion of the substrate depletion layer. Therefore, the SPBL both improved the vertical breakdown voltage (BVver) and suppressed an increase in the specific on-resistance (Ron,sp). The results of simulations showed a 14.46% higher TrBV and a 46.25% lower Ron,sp for the SPBL SOI LDMOS compared to those of the SOI LDMOS. As the SPBL optimized the vertical electric field at the drain, the turn-off non-breakdown time (Tnonbv) of the SPBL SOI LDMOS was 65.64% longer than that of the SOI LDMOS. The SPBL SOI LDMOS also demonstrated that TrBV was 10% higher, Ron,sp was 37.74% lower, and Tnonbv was 10% longer than those of the double RESURF SOI LDMOS.
Nosocomial Infections in Adult Patients Supported by Extracorporeal Membrane Oxygenation in a Cardiac Intensive Care Unit
Authors: Mornese Pinna Simone , Sousa Casasnovas Iago , Olmedo María , Machado Marina , Juàrez Fernández Miriam , Devesa-Cordero Carolina , Galar Alicia , Alvarez-Uria Ana , Fernández-Avilés Francisco , García Carreño Jorge , Martínez-Sellés Manuel , De Rosa Francesco Giuseppe , Corcione Silvia , Bouza Emilio , Muñoz Patricia , Valerio Maricela
Published: April 2023

The use of venoarterial (VA) extracorporeal membrane oxygenation therapy (ECMO) in patients admitted to cardiac intensive care units (CICU) has increased. Data regarding infections in this population are scarce. In this retrospective study, we analyzed the risk factors, outcome, and predictors of in-hospital mortality due to nosocomial infections in patients with ECMO admitted to a single coronary intensive care unit between July 2013 and March 2019 treated with VA-ECMO for >48 h. From 69 patients treated with VA-ECMO >48 h, (median age 58 years), 29 (42.0%) patients developed 34 episodes of infections with an infection rate of 0.92/1000 ECMO days. The most frequent were ventilator-associated pneumonia (57.6%), tracheobronchitis (9.1%), bloodstream infections (9.1%), skin and soft tissue infections (9.1%), and cytomegalovirus reactivation (9.1%). In-hospital mortality was 47.8%, but no association with nosocomial infections was found (p = 0.75). The number of days on ECMO (OR 1.14, 95% CI 1.01–1.30, p = 0.029) and noninfectious complications were higher in the infected patients (OR: 3.8 95% CI = 1.05–14.1). A higher baseline creatinine value (OR: 8.2 95% CI = 1.12–60.2) and higher blood lactate level at 4 h after ECMO initiation (OR: 2.0 95% CI = 1.23–3.29) were significant and independent risk factors for mortality. Conclusions: Nosocomial infections in medical patients treated with VA-ECMO are very frequent, mostly Gram-negative respiratory infections. Preventive measures could play an important role for these patients.
Probiotics for Neurodegenerative Diseases: A Systemic Review
Authors: Ojha Sandhya , Patil Nil , Jain Mukul , Kole Chittaranjan , Kaushik Prashant
Published: April 2023

Neurodegenerative disorders (ND) are a group of conditions that affect the neurons in the brain and spinal cord, leading to their degeneration and eventually causing the loss of function in the affected areas. These disorders can be caused by a range of factors, including genetics, environmental factors, and lifestyle choices. Major pathological signs of these diseases are protein misfolding, proteosomal dysfunction, aggregation, inadequate degradation, oxidative stress, free radical formation, mitochondrial dysfunctions, impaired bioenergetics, DNA damage, fragmentation of Golgi apparatus neurons, disruption of axonal transport, dysfunction of neurotrophins (NTFs), neuroinflammatory or neuroimmune processes, and neurohumoral symptoms. According to recent studies, defects or imbalances in gut microbiota can directly lead to neurological disorders through the gut-brain axis. Probiotics in ND are recommended to prevent cognitive dysfunction, which is a major symptom of these diseases. Many in vivo and clinical trials have revealed that probiotics (Lactobacillus acidophilus, Bifidobacterium bifidum, and Lactobacillus casei, etc.) are effective candidates against the progression of ND. It has been proven that the inflammatory process and oxidative stress can be modulated by modifying the gut microbiota with the help of probiotics. As a result, this study provides an overview of the available data, bacterial variety, gut-brain axis defects, and probiotics’ mode of action in averting ND. A literature search on particular sites, including PubMed, Nature, and Springer Link, has identified articles that might be pertinent to this subject. The search contains the following few groups of terms: (1) Neurodegenerative disorders and Probiotics OR (2) Probiotics and Neurodegenerative disorders. The outcomes of this study aid in elucidating the relationship between the effects of probiotics on different neurodegenerative disorders. This systematic review will assist in discovering new treatments in the future, as probiotics are generally safe and cause mild side effects in some cases in the human body.
Trichoderma asperellum Extract Isolated from Brazil Nuts (Bertholletia excelsa BONPL): In Vivo and In Silico Studies on Melanogenesis in Zebrafish
Authors: Ferreira Adriana Maciel , da Silva Sena Iracirema , Curti Jhone , de Souza Agerdânio Andrade , dos Santos Lima Paulo Cesar , Rodrigues Alex Bruno Lobato , da Silva Ramos Ryan , de Souza Pinheiro Wandson Braamcamp , Ferreira Irlon Maciel , Carvalho José Carlos Tavares
Published: April 2023

Endophytic fungi are those that present part of their life cycle in healthy tissues of different plant hosts in symbiosis without causing harm. At the same time, fungus-plant symbiosis makes it possible for microorganisms to synthesize their own bioactive secondary metabolites while in the stationary stage. To accomplish this, the endophytic fungus Trichoderma asperellum was isolated from Bertholletia excelsa (Brazil nut) almonds. The fungus was cultivated and extracted with ethyl acetate, obtaining AM07Ac. Then, using HPTLC (High-performance thin-layer chromatography) and nuclear magnetic resonance (1H NMR), β-amyrin, kaempferol, and brucine were identified as major compounds. Further in vivo assays in zebrafish demonstrated the activity of AM07Ac on melanogenesis by producing a concentration–response inhibitory effect, which, through an in silico study, proved to be related to the noted major compounds known to inhibit tyrosinase activity. The inhibition of tyrosinase prevents melanin accumulation in skin. Therefore, these results imply the importance of investigating microorganisms and their pharmacological activities, in particular the endophytic fungus Trichoderma asperellum as a generator of active metabolites for melanogenesis modulation.
Blood and Tissue Advanced Glycation End Products as Determinants of Cardiometabolic Disorders Focusing on Human Studies
Authors: Kim Yoona
Published: April 2023

Cardiometabolic disorders are characterised by a cluster of interactive risk determinants such as increases in blood glucose, lipids and body weight, as well as elevated inflammation and oxidative stress and gut microbiome changes. These disorders are associated with onset of type 2 diabetes mellitus (T2DM) and cardiovascular disease (CVD). T2DM is strongly associated with CVD. Dietary advanced glycation end products (dAGEs) attributable from modern diets high in sugar and/or fat, highly processed foods and high heat-treated foods can contribute to metabolic etiologies of cardiometabolic disorders. This mini review aims to determine whether blood dAGEs levels and tissue dAGEs levels are determinants of the prevalence of cardiometabolic disorders through recent human studies. ELISA (enzyme-linked immunosorbent assay), high-performance liquid chromatography (HPLC), liquid chromatography-mass spectrometry (LC-MS) and gas chromatography-mass spectrometry (GC-MS) for blood dAGEs measurement and skin auto fluorescence (SAF) for skin AGEs measurement can be used. Recent human studies support that a diet high in AGEs can negatively influence glucose control, body weight, blood lipid levels and vascular health through the elevated oxidative stress, inflammation, blood pressure and endothelial dysfunction compared with a diet low in AGEs. Limited human studies suggested a diet high in AGEs could negatively alter gut microbiota. SAF could be considered as one of the predictors affecting risks for cardiometabolic disorders. More intervention studies are needed to determine how dAGEs are associated with the prevalence of cardiometabolic disorders through gut microbiota changes. Further human studies are conducted to find the association between CVD events, CVD mortality and total mortality through SAF measurement, and a consensus on whether tissue dAGEs act as a predictor of CVD is required.
Urinary Tract Infections: The Current Scenario and Future Prospects
Authors: Mancuso Giuseppe , Midiri Angelina , Gerace Elisabetta , Marra Maria , Zummo Sebastiana , Biondo Carmelo
Published: April 2023

Urinary tract infections (UTIs) are among the most common bacterial infections worldwide, occurring in both community and healthcare settings. Although the clinical symptoms of UTIs are heterogeneous and range from uncomplicated (uUTIs) to complicated (cUTIs), most UTIs are usually treated empirically. Bacteria are the main causative agents of these infections, although more rarely, other microorganisms, such as fungi and some viruses, have been reported to be responsible for UTIs. Uropathogenic Escherichia coli (UPEC) is the most common causative agent for both uUTIs and cUTIs, followed by other pathogenic microorganisms, such as Klebsiella pneumoniae, Proteus mirabilis, Enterococcus faecalis, and Staphylococcus spp. In addition, the incidence of UTIs caused by multidrug resistance (MDR) is increasing, resulting in a significant increase in the spread of antibiotic resistance and the economic burden of these infections. Here, we discuss the various factors associated with UTIs, including the mechanisms of pathogenicity related to the bacteria that cause UTIs and the emergence of increasing resistance in UTI pathogens.
Viability of African Swine Fever Virus with the Shallow Burial with Carbon Carcass Disposal Method
Authors: Duc Hoang Minh , Hutchinson Mark , Flory Gary A. , Ngan Pham Hong , Son Hoang Minh , Hung Le Van , Hoa Tran Thi Khanh , Lan Nguyen Thi , Lam Truong Quang , Rozeboom Dale , Remmenga Marta D. , Vuolo Matthew , Miknis Robert , Burns Amira , Flory Renée
Published: April 2023

African swine fever (ASF) is a highly contagious swine disease with high mortality. In many countries, culling pigs infected and exposed to the ASF virus is mandatory to control the disease, which poses a real challenge in the disposal of large numbers of carcasses during ASF outbreaks. Shallow burial with carbon (SBC) Thanks ew mortality disposal method developed from deep burial and composting. The present study investigates the effectiveness of SBC in disposing of ASF virus-infected pigs. The real-time PCR results showed that DNA of the ASF virus was still detected in bone marrow samples on day 56, while the virus isolation test revealed that the infectious ASF virus was destroyed in both spleen and bone marrow samples on day 5. Interestingly, decomposition was found to occur rapidly in these shallow burial pits. On day 144, only large bones were found in the burial pit. In general, the results of this study indicated that SBC is a potential method for the disposal of ASF-infected carcasses; however, further studies are needed to provide more scientific evidence for the efficacy of SBC in different environment conditions.
The First Anti-Snakebite and Hepatoprotective Characterization of a Trypsin Kunitz-like Inhibitor (EcTI) from the Plant Enterolobium contortisiliquum; A Case of Two Soul Mates Meeting
Authors: Costa Caroline R. C. , Belchor Mariana N. , Roggero Airam , Moraes Laila L. , Samelo Ricardo , Annunciato Isabelly , Bonturi Camila R. , Oliva Maria L. V. , Sousa Sergio F. , de Oliveira Marcos A. , Toyama Marcos H.
Published: April 2023

Snake venom serine protease (SVSP) interferes with the regulation and control of important biological reactions in homeostasis and can be classified as an activator of the fibrinolytic system and platelet aggregation. Our group has recently isolated a new serine protease from Crotalus durissus terrificus total venom (Cdtsp-2). This protein exhibits edematogenic capacity and myotoxic activity. A Kunitz-like EcTI inhibitor protein with a molecular mass of 20 kDa was isolated from Enterolobium contortisiliquum and showed high trypsin inhibition. Thus, the objective of this work is to verify the possible inhibition of the pharmacological activities of Cdtsp-2 by the Kutinz-type inhibitor EcTI. To isolate Cdtsp-2 from total C. d. terrificus venom, we used three-step chromatographic HPLC. Using the mice paw edema model, we observed an edematogenic effect, myotoxicity and hepatotoxicity caused by Cdtsp-2. In vitro and in vivo experiments showed that the alterations in hemostasis caused by Cdtsp-2 are crucial for the development of marked hepatotoxicity and that EcTI significantly inhibits the enzymatic and pharmacological activities of Cdtsp-2. Kunitz-like inhibitor may be a viable alternative for the development of ancillary treatments against the biological activities of venoms.
Efficacy of Mentha aquatica L. Essential Oil (Linalool/Linalool Acetate Chemotype) against Insect Vectors and Agricultural Pests
Authors: Ferrati Marta , Spinozzi Eleonora , Baldassarri Cecilia , Maggi Filippo , Pavela Roman , Canale Angelo , Petrelli Riccardo , Cappellacci Loredana
Published: April 2023

In recent years, agrochemical industries have been focused on the development of essential oil (EO)-based biopesticides, which can be considered valuable alternatives to traditional chemical products. The genus Mentha (Lamiaceae) comprises 30 species characterized by a wide range of biological activities, and some of their EOs showed good potential as pesticidal agents. In this regard, the aim of this study was to evaluate the insecticidal activity of the EO obtained from a rare linalool/linalool acetate chemotype of Mentha aquatica L. The EO was found to be highly effective against Culex quinquefasciatus (Say) 2nd instar larvae, Metopolophium dirhodum (Walker) adults, Spodoptera littoralis (Boisduval) 2nd instar larvae, and Tetranychus urticae (Koch) adults, showing lethal concentrations (LC50) or doses (LD50) of 31.5 ± 2.2 µL L−1, 4.9 ± 0.8 mL L−1, 18.5 ± 2.1 µg larvae−1, and 3.3 ± 0.5 mL L−1, respectively. On the contrary, Musca domestica L. adults and 3rd instar larvae of C. quinquefasciatus and S. littoralis were moderately affected by the treatment (LC50 or LD50: 71.4 ± 7.2 µg adult−1, 79.4 ± 5.2 µL L−1, 44.2 ± 5.8 µg larvae−1, respectively). The results obtained in this work demonstrated that various insects and pests could be differently sensible to the same EO and may lead to the exploitation of this plant or its major volatile compounds as novel ingredients of botanical insecticides and pesticides.
Hydroxyapatite Thin Films of Marine Origin as Sustainable Candidates for Dental Implants
Authors: Dorcioman Gabriela , Grumezescu Valentina , Stan George E. , Chifiriuc Mariana Carmen , Gradisteanu Gratiela Pircalabioru , Miculescu Florin , Matei Elena , Popescu-Pelin Gianina , Zgura Irina , Craciun Valentin , Oktar Faik Nüzhet , Duta Liviu
Published: April 2023

Novel biomaterials with promising bone regeneration potential, derived from rich, renewable, and cheap sources, are reported. Thus, thin films were synthesized from marine-derived (i.e., from fish bones and seashells) hydroxyapatite (MdHA) by pulsed laser deposition (PLD) technique. Besides the physical–chemical and mechanical investigations, the deposited thin films were also evaluated in vitro using dedicated cytocompatibility and antimicrobial assays. The morphological examination of MdHA films revealed the fabrication of rough surfaces, which were shown to favor good cell adhesion, and furthermore could foster the in-situ anchorage of implants. The strong hydrophilic behavior of the thin films was evidenced by contact angle (CA) measurements, with values in the range of 15–18°. The inferred bonding strength adherence values were superior (i.e., ~49 MPa) to the threshold established by ISO regulation for high-load implant coatings. After immersion in biological fluids, the growth of an apatite-based layer was noted, which indicated the good mineralization capacity of the MdHA films. All PLD films exhibited low cytotoxicity on osteoblast, fibroblast, and epithelial cells. Moreover, a persistent protective effect against bacterial and fungal colonization (i.e., 1- to 3-log reduction of E. coli, E. faecalis, and C. albicans growth) was demonstrated after 48 h of incubation, with respect to the Ti control. The good cytocompatibility and effective antimicrobial activity, along with the reduced fabrication costs from sustainable sources (available in large quantities), should, therefore, recommend the MdHA materials proposed herein as innovative and viable solutions for the development of novel coatings for metallic dental implants.
Controlled Release of Flurbiprofen from 3D-Printed and Supercritical Carbon Dioxide Processed Methacrylate-Based Polymer
Authors: Ngo Truc T. , Kim Jae D.
Published: April 2023

The ability to engineer and predict drug release behavior during treatment is critical to the design and implementation of effective drug delivery systems. In this study, a drug delivery system consisting of a methacrylate-based polymer and flurbiprofen was studied, and its release profile in a controlled phosphate-buffered saline solution was characterized. The polymer, which was 3D printed and processed in supercritical carbon dioxide under different temperature and pressure settings, showed sustained drug release over a prolonged period. A computer algorithm was used to determine the drug release time duration before reaching steady state and the maximum drug release at steady state. Several empirical models were applied to fit the release kinetic data to gain information about the drug release mechanism. The diffusion coefficients for each system were also estimated using Fick’s law. Based on the results, the influence of supercritical carbon dioxide processing conditions on the diffusion behavior is interpreted, providing insights into the effective and tunable design of drug delivery systems for targeted treatment specifications.
A Multi-Criteria Decision Aid Tool for Radiopharmaceutical Selection in Tau PET Imaging
Authors: Ozsahin Ilker , Onakpojeruo Efe Precious , Uzun Berna , Uzun Ozsahin Dilber , Butler Tracy A.
Published: April 2023

The accumulation of pathologically misfolded tau is a feature shared by a group of neurodegenerative disorders collectively referred to as tauopathies. Alzheimer’s disease (AD) is the most prevalent of these tauopathies. Immunohistochemical evaluation allows neuropathologists to visualize paired-helical filaments (PHFs)—tau pathological lesions, but this is possible only after death and only shows tau in the portion of brain sampled. Positron emission tomography (PET) imaging allows both the quantitative and qualitative analysis of pathology over the whole brain of a living subject. The ability to detect and quantify tau pathology in vivo using PET can aid in the early diagnosis of AD, provide a way to monitor disease progression, and determine the effectiveness of therapeutic interventions aimed at reducing tau pathology. Several tau-specific PET radiotracers are now available for research purposes, and one is approved for clinical use. This study aims to analyze, compare, and rank currently available tau PET radiotracers using the fuzzy preference ranking organization method for enrichment of evaluations (PROMETHEE), which is a multi-criteria decision-making (MCDM) tool. The evaluation is based on relatively weighted criteria, such as specificity, target binding affinity, brain uptake, brain penetration, and rates of adverse reactions. Based on the selected criteria and assigned weights, this study shows that a second-generation tau tracer, [18F]RO-948, may be the most favorable. This flexible method can be extended and updated to include new tracers, additional criteria, and modified weights to help researchers and clinicians select the optimal tau PET tracer for specific purposes. Additional work is needed to confirm these results, including a systematic approach to defining and weighting criteria and clinical validation of tracers in different diseases and patient populations.
Amphiphilic Polypeptides Obtained by Post-Polymerization Modification of Poly-l-Lysine as Systems for Combined Delivery of Paclitaxel and siRNA
Authors: Dzhuzha Apollinariia , Gandalipov Erik , Korzhikov-Vlakh Viktor , Katernyuk Elena , Zakharova Natalia , Silonov Sergey , Tennikova Tatiana , Korzhikova-Vlakh Evgenia
Published: April 2023

The development of effective anti-cancer therapeutics remains one of the current pharmaceutical challenges. The joint delivery of chemotherapeutic agents and biopharmaceuticals is a cutting-edge approach to creating therapeutic agents of enhanced efficacy. In this study, amphiphilic polypeptide delivery systems capable of loading both hydrophobic drug and small interfering RNA (siRNA) were developed. The synthesis of amphiphilic polypeptides included two steps: (i) synthesis of poly-αl-lysine by ring-opening polymerization and (ii) its post-polymerization modification with hydrophobic l-amino acid and l-arginine/l-histidine. The obtained polymers were used for the preparation of single and dual delivery systems of PTX and short double-stranded nucleic acid. The obtained double component systems were quite compact and had a hydrodynamic diameter in the range of 90–200 nm depending on the polypeptide. The release of PTX from the formulations was studied, and the release profiles were approximated using a number of mathematical dissolution models to establish the most probable release mechanism. A determination of the cytotoxicity in normal (HEK 293T) and cancer (HeLa and A549) cells revealed the higher toxicity of the polypeptide particles to cancer cells. The separate evaluation of the biological activity of PTX and anti-GFP siRNA formulations testified the inhibitory efficiency of PTX formulations based on all polypeptides (IC50 4.5–6.2 ng/mL), while gene silencing was effective only for the Tyr-Arg-containing polypeptide (56–70% GFP knockdown).
Influence of Solid Oral Dosage Form Characteristics on Swallowability, Visual Perception, and Handling in Older Adults
Authors: Hummler Henriette , Page Susanne , Stillhart Cordula , Meilicke Lisa , Grimm Michael , Mannaa Marwan , Gollasch Maik , Weitschies Werner
Published: April 2023

Swallowability, visual perception, and any handling to be conducted prior to use are all influence factors on the acceptability of an oral dosage form by the patient. Knowing the dosage form preferences of older adults, as the major group of medication end users, is needed for patient-centric drug development. This study aimed at evaluating the ability of older adults to handle tablets as well as to assess the anticipated swallowability of tablets, capsules, and mini tablets based on visual perception. The randomized intervention study included 52 older adults (65 to 94 years) and 52 younger adults (19 to 36 years). Within the tested tablets, ranging from 125 mg up to 1000 mg in weight and being of different shapes, handling was not seen as the limiting factor for the decision on appropriate tablet size. However, the smallest sized tablets were rated worst. According to visual perception, the limit of acceptable tablet size was reached at around 250 mg for older adults. For younger adults, this limit was shifted to higher weights and was dependent on the tablet shape. Differences in anticipated swallowability with respect to tablet shapes were most pronounced for tablets of 500 mg and 750 mg in weight, independent of the age category. Capsules performed worse compared to tablets, while mini tablets appeared as a possible alternative dosage form to tablets of higher weight. Within the deglutition part of this study, swallowability capabilities of the same populations were assessed and have been reported previously. Comparing the present results with the swallowing capabilities of the same populations with respect to tablets, it shows adults’ clear self-underestimation of their ability to swallow tablets independent of their age.
Psychotherapy as Ethics
Authors: Gipps Richard G. T.
Published: April 2023

Talk of matters ethical is, in the psychotherapeutic context, typically relegated to therapy’s preconditions and setting, i.e., to its ‘frame’. What goes on within that frame, i.e., therapeutic action itself, gets theorised in psychological rather than ethical terms. An explanation for this is the frequent therapeutic imperative to extirpate self-directed moralising. Moralising, however, constitutes but a phoney pretender to the ethical life. A true ethical sensibility instead shows itself in such moments of life as involve our offering humane recognition to one another and to ourselves. Being offered such recognition not only allows a patient to internalise it as a remoralising dignity or healthy pride. It also enables the patient to know herself by animating within herself a range of virtue concepts—courage, probity, repentance, etc.—which can then function as regulative ideals for a well-functioning psyche. Inchoate anxiety now takes shape as intelligible guilt. Repentance and the repair of damaged relationships now replace blame’s repression or projection. Conscience now becomes a motor for therapeutic change. In such ways, ethical concern constitutes not merely the frame but the living flesh of the therapeutic project.
Low-Complexity Modulation Format Identification Based on Amplitude Histogram Distributions for Digital Coherent Receivers
Authors: Hao Ming , Jiang Xuedong , Xiong Xingzhong , Giddings Roger , He Wei , Tang Jianming
Published: April 2023

In this work, a prior-training-free and low-complexity modulation format identification (MFI) scheme, based on amplitude histogram distributions, was proposed and demonstrated, both numerically and experimentally, for autonomous digital coherent receivers. In the proposed scheme, after having performed power normalization, incoming polarization division multiplexed (PDM) signals were classified into QPSK, 8QAM, 16QAM, 32QAM and 64QAM signals, according to their ratios. Ratios were defined according to specific features of their amplitude histograms. The proposed MFI scheme used only amplitude information. As such, it was insensitive to carrier phase noise. Furthermore, the proposed scheme did not require any prior information, such as optical signal-to-noise ratio (OSNR). The performance of the proposed MFI scheme was numerically verified using 28GBaud PDM-QPSK/-8QAM/-16QAM/-32QAM/-64QAM signals. The numerical simulation results showed that the proposed scheme was able achieve a 100% correct identification rate for all five modulation formats when their OSNR values were higher than the thresholds corresponding to the 20% FEC correcting bit error rate (BER) of 2.4 × 10−2. To further explore the effectiveness of the proposed MFI scheme, proof-of-concept experiments in 28GBaud PDM-QPSK/-8QAM/-16QAM, and 21.5GBaud PDM-32QAM transmission systems were also undertaken, which showed that the proposed scheme as robust against fiber nonlinearities. To explore the scheme’s feasibility for use in practical transmission systems, the computational complexity analysis of the proposed scheme was conducted. It showed that, compared with relevant MFI schemes, the proposed MFI scheme was able to significantly reduce the computational complexity.
Preparation of Antireflection Microstructures on ZnSe Crystal by Femtosecond Burst Bessel Direct Laser Writing
Authors: Zhou Sikun , Yang Junjie , Wang Sha , Wang Shutong , Deng Guoliang , Zhou Shouhuan
Published: April 2023

In this work, we fabricated the antireflection microstructures (ARMs) on ZnSe surfaces using a femtosecond Bessel direct laser writing in burst mode. The morphology and transmittance performance of ARMs with different single-pulse energies (from 200 nJ to 500 nJ), different burst modes (burst 1, 3, and 5 modes), different periods (from 3 μm to 6 μm), and different arrangements were investigated. The results revealed that tetragonally arranged ARMs fabricated by 500 nJ of single-pulse energy, the burst 3 mode, and a period of 3 μm show the best transmittance performance. The average transmittance of the ARMs was about 17.13% higher than that of bulk ZnSe in the range of 8–12 μm, and the highest transmittance of 81.75% (an improvement of 18.63% on one side of the ZnSe) was achieved at 12.36 μm. This process makes it possible to enhance ARMs’ transmittance in the infrared wavelength range by using direct laser writing in burst mode.
Study on Road Performance of Polyurethane Cold-Recycled Mixture
Authors: Li Zhenxia , Guo Tengteng , Chen Yuanzhao , Zhang Tong , Tang Deqing , Hao Menghui , Zhao Xu , Liu Jinyuan
Published: April 2023

To give full play to the advantages of polyurethane as a binder, such as mixing at room temperature, short curing time, and high curing strength, polyurethane was used as the binder of a waste asphalt mixture, and the pavement performance of PCRM (Polyurethane Cold-Recycled Mixture) was analyzed. Firstly, the adhesion performance of polyurethane binder with new and old aggregates was evaluated using the adhesion test. Then, the mix proportion was designed according to the material characteristics, and the reasonable molding process, maintenance conditions, design indexes, and the optimal binder ratio were proposed. Secondly, the high-temperature stability, low-temperature crack resistance, water stability, and compressive resilient modulus of the mixture were evaluated through laboratory tests. Finally, the pore structure and microscopic morphology of polyurethane cold-recycled mixture were analyzed by industrial CT (Computerized Tomography) scanning, and the failure mechanism of polyurethane cold-recycled mixture was revealed. The test results show that the adhesion between polyurethane and RAP (Reclaimed Asphalt Pavement) is good, and the splitting strength of the mixture increases greatly when the ratio of glue to stone reaches 9%. Polyurethane binder has low sensitivity to temperature and poor water stability. With the increase of RAP content, the high-temperature stability, low-temperature crack resistance, and compressive resilient modulus of PCRM showed a decreasing trend. When the RAP content was less than 40%, the freeze–thaw splitting strength ratio of the mixture was improved. After the incorporation of RAP, the interface was more complex and there were many micron-scale holes, cracks, and other defects; after high-temperature immersion, the polyurethane binder appeared to show a certain degree of peeling at the holes of the RAP surface. After freeze–thaw, the polyurethane binder on the surface of the mixture produced many cracks. The study of polyurethane cold-recycled mixture is of great significance to realize green construction.
Biodegradable Preformed Particle Gel (PPG) Made of Natural Chitosan Material for Water Shut-Off Application
Authors: Elaf Reem , Ben Ali Ahmed , Saad Mohammed , Hussein Ibnelwaleed A. , Nimir Hassan , Bai Baojun
Published: April 2023

Oil and gas extraction frequently produces substantial volumes of produced water, leading to several mechanical and environmental issues. Several methods have been applied over decades, including chemical processes such as in-situ crosslinked polymer gel and preformed particle gel, which are the most effective nowadays. This study developed a green and biodegradable PPG made of PAM and chitosan as a blocking agent for water shutoff, which will contribute to combating the toxicity of several commercially used PPGs. The applicability of chitosan to act as a crosslinker has been confirmed by FTIR spectroscopy and observed by scanning electron microscopy. Extensive swelling capacity measurements and rheological experiments were performed to examine the optimal formulation of PAM/Cs based on several PAM and chitosan concentrations and the effects of typical reservoir conditions, such as salinity, temperature, and pH. The optimum concentrations of PAM with 0.5 wt% chitosan were between 5–9 wt%, while the optimum chitosan amount with 6.5 wt% PAM was in the 0.25–0.5 wt% range, as these concentrations can produce PPGs with high swellability and sufficient strength. The swelling capacity of PAM/Cs is lower in high saline water (HSW) with a TDS of 67.2976 g/L compared with fresh water, which is related to the osmotic pressure gradient between the swelling medium and the PPG. The swelling capacity in freshwater was up to 80.37 g/g, while it is 18.73 g/g in HSW. The storage moduli were higher in HSW than freshwater, with ranges of 1695–5000 Pa and 2053–5989 Pa, respectively. The storage modulus of PAM/Cs samples was higher in a neutral medium (pH = 6), where the fluctuation behavior in different pH conditions is related to electrostatic repulsions and hydrogen bond formation. The increase in swelling capacity caused by the progressive increment in temperature is associated with the amide group’s hydrolysis to carboxylate groups. The sizes of the swollen particles are controllable since they are designed to be 0.63–1.62 mm in DIW and 0.86–1.00 mm in HSW. PAM/Cs showed promising swelling and rheological characteristics while demonstrating long-term thermal and hydrolytic stability in high-temperature and high-salinity conditions.
Effects of Butadiene Sulfone as an Electrolyte Additive on the Formation of Solid Electrolyte Interphase in Lithium-Ion Batteries Based on Li4Ti5O12 Anode Materials
Authors: Kung Yu-Ruei , Li Cheng-Yao , Hasin Panitat , Su Chia-Hung , Lin Jeng-Yu
Published: April 2023

In this study, butadiene sulfone (BS) was selected as an efficient electrolyte additive to stabilize the solid electrolyte interface (SEI) film on the lithium titanium oxide (LTO) electrodes in Li-ion batteries (LIBs). It was found that the use of BS as an additive could accelerate the growth of stable SEI film on the LTO surface, leading to the improved electrochemical stability of LTO electrodes. It can be supported by the BS additive to effectively reduce the thickness of SEI film, and it significantly enhances the electron migration in the SEI film. Consequently, the LIB-based LTO anode in the electrolyte containing 0.5 wt.% BS showed a superior electrochemical performance to that in the absence of BS. This work provides a new prospect for an efficient electrolyte additive for next-generation LIBs-based LTO anodes, especially when discharged to low voltage.
Polymer Supercritical CO2 Foaming under Peculiar Conditions: Laser and Ultrasound Implementation
Authors: Villamil Jiménez Jennifer Andrea , Haurat Margaux , Berriche Rayan , Baillon Fabien , Sauceau Martial , Chaussat Mattéo , Tallon Jean-Marc , Kusiak Andrzej , Dumon Michel
Published: April 2023

The two-step batch foaming process of solid-state assisted by supercritical CO2 is a versatile technique for the foaming of polymers. In this work, it was assisted by an out-of-autoclave technology: either using lasers or ultrasound (US). Laser-aided foaming was only tested in the preliminary experiments; most of the work involved US. Foaming was carried out on bulk thick samples (PMMA). The effect of ultrasound on the cellular morphology was a function of the foaming temperature. Thanks to US, cell size was slightly decreased, cell density was increased, and interestingly, thermal conductivity was shown to decrease. The effect on the porosity was more remarkable at high temperatures. Both techniques provided micro porosity. This first investigation of these two potential methods for the assistance of supercritical CO2 batch foaming opens the door to new investigations. The different properties of the ultrasound method and its effects will be studied in an upcoming publication.
Polymer Screening for Efficient Water Cut Reduction in a Sandstone Oilfield in Kazakhstan
Authors: Yerniyazov Daniyar , Yesmukhambet Madi , Kenes Razida , Bukayev Azamat , Shakeel Mariam , Pourafshary Peyman , Musharova Darya
Published: April 2023

Polymer flooding is one of the most widely used and effective enhanced oil recovery techniques. It can improve the macroscopic sweep efficiency of a reservoir by controlling the fractional flow of water. The applicability of polymer flooding for one of the sandstone fields in Kazakhstan was evaluated in this study and polymer screening was carried out to choose the most appropriate polymer among four hydrolyzed polyacrylamide polymer samples. Polymer samples were prepared in Caspian seawater (CSW) and assessed based on rheology, thermal stability, sensitivity to non-ionic materials and oxygen, and static adsorption. All the tests were performed at a reservoir temperature of 63 °C. Based on the results of the screening study, tolerance of a polymer towards high-temperature reservoir conditions, resistance to bacterial activity and dissolved oxygen present in make-up brine, chemical degradation, and reduced adsorption on rock surface were considered the most important screening parameters. As a result of this screening study, one out of four polymers was selected for the target field as it showed a negligible effect of bacterial activity on thermal stability. The results of static adsorption also showed 13–14% lower adsorption of the selected polymer compared to other polymers tested in the study. The results of this study demonstrate important screening criteria to be followed during polymer selection for an oilfield as the polymer should be selected based on not only polymer characteristics but also the polymer interactions with the ionic and non-ionic components of the make-up brine.
Statistical Copolymers of N–Vinylpyrrolidone and 2–Chloroethyl Vinyl Ether via Radical RAFT Polymerization: Monomer Reactivity Ratios, Thermal Properties, and Kinetics of Thermal Decomposition of the Statistical Copolymers
Authors: Plachouras Nikolaos V. , Pitsikalis Marinos
Published: April 2023

The radical statistical copolymerization of N–vinyl pyrrolidone (NVP) and 2–chloroethyl vinyl ether (CEVE) was conducted using the Reversible Addition–Fragmentation chain Transfer (RAFT) polymerization technique, employing [(O–ethylxanthyl)methyl]benzene (CTA-1) and O–ethyl S–(phthalimidylmethyl) xanthate (CTA-2) as the Chain Transfer Agents (CTAs), leading to P(NVP–stat–CEVE) products. After optimizing copolymerization conditions, monomer reactivity ratios were estimated using various linear graphical methods, as well as the COPOINT program, which was applied in the framework of the terminal model. Structural parameters of the copolymers were obtained by calculating the dyad sequence fractions and the monomers’ mean sequence lengths. Thermal properties of the copolymers were studied by Differential Scanning Calorimetry (DSC) and kinetics of their thermal degradation by Thermogravimetric Analysis (TGA) and Differential Thermogravimetry (DTG), applying the isoconversional methodologies of Ozawa–Flynn–Wall (OFW) and Kissinger–Akahira–Sunose (KAS).