bluuebunny/crossref_metadata_2025 huggingface dataset:
ATIVIDADE FARMACOLÓGICA DE ÓLEOS ESSENCIAIS NO SISTEMA RESPIRATÓRIO: UMA REVISÃO SISTEMÁTICA DE ESTUDOS PRÉ-CLÍNICOS
Authors: Menezes Pedro Modesto Nascimento , Brito Mariana Coelho , Lucchese Angélica Maria , Lima Julianeli Tolentino de , Ribeiro Luciano Augusto de Almeida , Silva Fabrício Souza
Published: January 2018

Os óleos essenciais são uma mistura de diversos compostos voláteis, que são extraídos de plantas aromáticas e que possuem diversas propriedades farmacológicas. Entre as propriedades farmacológicas, descritas na literatura para esses óleos essenciais, destacam-se os efeitos repelente, anti-inflamatório, antiasmático, ansiolítico e anticâncer. Neste trabalho, destacamos de forma sistemática o uso de plantas aromáticas no tratamento de enfermidades relacionadas ao sistema respiratório, relacionando espécies que são fontes de óleos essenciais e cujos efeitos farmacológicos foram avaliados em modelos animais, envolvendo a investigação de sua atividade antiasmática, antitussígena e/ou expectorante. Para tanto, foram pesquisadas em bases de dados (Pubmed/Medline, Scopus e Biblioteca Virtual de Saúde) artigos com as seguintes palavras-chave: “essential oil” e “spasmolytic”, “essential oil” e “airway smooth muscle”, “essential oil” e “anthiasthmatic”, “essential oil” e “antitussive”, “essential oil” e “cough”, “essential oil” e “mucolytics” ou “essential oil” e “expectorant”. De um total de 868 artigos pesquisados, que continham as palavras-chave no título e/ou no resumo, foram encontradas 28 espécies de plantas com estudos relacionados à atividade de seus óleos essenciais no sistema respiratório.
ANÁLISE DOS PARÂMETROS MORFOMÉTRICOS DA SUB-BACIA HIDROGRÁFICA DO RIACHO CARAÚNA, EM QUIXERAMOBIM (CEARÁ)
Authors: Rodrigues Lima Wagner José , Dos Santos Francílio De Amorim , Da Cruz Maria Lúcia Brito
Published: January 2018

O presente estudo propôs-se realizar a compartimentação da Sub-Bacia do riacho Caraúna (SBRC), analisar os parâmetros morfométrica, entender os processos erosivos e identificar as áreas potencialmente suscetíveis a eventos erosivos intensos. A Sub-Baciaestudada está localizada em Quixeramobim, estado do Ceará, possui uma área de 119 km2, que representa 3,6% da área do referido município. A SBRC integra a Bacia Hidrográfica de planejamento do rio Banabuiú. Utilizou-se imagem da Missão SRTM para delimitação e extração da rede de drenagem do objeto estudado. A proposta de compartimentação baseou-se em parâmetros como a densidade da rede de drenagem, densidade de riachos, linha divisora de águas e hipsometria. Os procedimentos técnicos foram realizados no Sistema de Informação Geográfica (SIG) Quantum GIS (QIGIS), versão 10.4 - Essen. Desse modo, a análise das características geométricas, da rede de drenagem e do relevo da MBRC, assim como sua compartimentação em alto, médio e baixo curso permitiuverificar que: (a) as áreas mais vulneráveis aos processos erosivos e com maiores declividades encontram-se no alto curso da Sub-Bacia; e (b) que tem forma alongada e que é pouco suscetível a eventos de inundações e enchentes.
DESTINAÇÃO DE EFLUENTES SANITÁRIOS NA ÁREA RURAL DO MUNICÍPIO DE CAÇADOR, SANTA CATARINA, BRASIL
Authors: Ferreira de Campos Roger Francisco , Borga Tiago , Mello Osni Ribeiro
Published: January 2018

Atualmente vinte por cento da população brasileira reside em áreas rurais, uma quantidade expressiva de pessoas que geram grande volume de resíduos sólidos e líquidos, necessitando de um olhar ambiental por parte da comunidade e principalmente pelos órgãos públicos ambientais. Portanto, o presente trabalho tem como objetivo realizar um levantamento descritivo sobre o atual cenário do esgotamento sanitário da área rural do município de Caçador/SC, com um levantamento qualitativo da atual realidade da destinação e tratamento dos efluentes sanitários do município. Com o estudo, pode-se concluir que as áreas rurais do município necessitam de um acompanhamento pelos órgãos ambientais do município, visto que 49.899% da população possuem poço negro (sumidouro), 44.064% o sistema de fossa e filtro, e 1.609% não possuem nenhum tipo de tratamento, causando impactos ambientais no solo devido à falta de tratamento. Assim, o presente estudo visa mostrar para a sociedade atual a presente realidade do município de Caçador, com a perspectiva de buscar alternativas sustentáveis para esses empecilhos ambientais. Conclui-se que o município necessita de um melhor acompanhamento sobre o esgotamento sanitário na área rural.
CARACTERIZAÇÃO MORFOMÉTRICA DA BACIA HIDROGRÁFICA DO RIO IVAÍ - PARANÁ
Authors: Souza Camila Furlan de , Pertille Carla Talita , Schramm Corrêa Bruno Jan , Vieira Francielle Santos
Published: January 2018

O objetivo desse estudo foi avaliar as propriedades morfométricas da bacia do Rio Ivaí, utilizando técnicas de geoprocessamento de forma a fornecer dados para planejamento e gestão de bacias hidrográficas do Estado do Paraná. O processamento dos dados foi realizado em ambiente SIG utilizando o aplicativo computacional ArcGIS 10.4/ArcMap®. Os parâmetros morfométricos avaliados foram: coeficiente de compacidade, fator de forma, índice de circularidade, índice de rugosidade, índice de alongamento, razão de elongação, índice de sinuosidade, razão de relevo, densidade de drenagem, densidade hidrográfica e coeficiente de manutenção. Os resultados para fator de forma e índice de circularidade foram muito baixos, o que indica o formato mais alongado da bacia. Enquanto o coeficiente de compacidade apresentou um valor alto, o que caracteriza uma baixa propensão à ocorrência de enchentes em condições normais de precipitação. A bacia é classificada como de 5ª ordem, ou seja, bem ramificada. Além disso, o relevo é caracterizado principalmente pela classe suavemente ondulado (47,15%), seguido da classe ondulado (29,99%). Conclui-se que a análise dos dados morfométricos permitiu compreender o regime hidrológico e inferir sobre o manejo e conservação da bacia do rio Ivaí.
Alexithymia in Relation to Alcohol Use, Emotion Recognition, and Empathy: The Role of Externally Oriented Thinking
Authors: Lyvers Michael , McCann Karrah , Coundouris Sarah , Edwards Mark S. , Thorberg Fred Arne
Published: January 2018

Both alcohol misuse and the externally oriented thinking (EOT) facet of alexithymia are associated with deficits in facial emotion recognition and emotional empathy. The aim of the present study was to investigate whether EOT mediates the association of drinking with these deficits, and to test the hypothesis that impaired facial emotion recognition mediates the relationship between EOT and low emotional empathy, in a nonclinical sample. The sample consisted of 161 men and women who completed an online survey that included the Alcohol Use Disorders Identification Test (AUDIT), Depression Anxiety Stress Scales, Interpersonal Reactivity Index (IRI), Reading the Mind in the Eyes Test (RMET), and Toronto Alexithymia Scale (TAS-20). In addition to replicating associations between TAS-20 and other measures, EOT was found to mediate relationships between potential alcohol misuse (as indexed by AUDIT) and facial emotion recognition (as indexed by RMET) as well as emotional empathy (as indexed by the corresponding subscale of the IRI) after controlling for mood and demographic variables. The negative relationship between EOT and emotional empathy was mediated by impaired facial emotion recognition. Present findings point to a likely role of the EOT trait in the reported associations of alcohol misuse with both poor emotion recognition and low emotional empathy, and a mediating role of poor emotion recognition in the relationship of EOT to the latter.
Exploring the Relationship Between Narcissism and Extreme Altruism
Authors: White Daniel , Szabo Marianna , Tiliopoulos Niko
Published: January 2018

Extreme altruism is defined as prosocial behavior that violates social norms or the law. Little research has been done on this phenomenon, although research into related areas suggests that, surprisingly, extreme altruistic activities may be associated with traits traditionally associated with narcissism. This relationship was explored by comparing members of the public, people involved in prosocial activities within socially and legally accepted realms, and members of the Real-Life Superhero (RLSH) movement. The RLSH movement is a subculture whose prosocial-directed activities often exceed social norms and legal constraints. These include patrolling and conducting community and citizen police work in superhero-inspired uniforms, which has on several occasions resulted in altercations with other civilians or with law enforcement. The results suggest that there is a relationship between certain traits within the narcissism spectrum and the proclivity to engage in extreme altruism. These traits include grandiose fantasy, self-sacrificing self-enhancement, and devaluing. Furthermore, these traits are expressed at significantly higher levels in people who engage in extreme altruism more often. Finally, a model based predominantly on narcissism indicated a strong ability to predict group membership among the three groups. The findings suggest that a reconceptualization that reflects the capacity of these traits to be expressed in a prosocial or antisocial behavior is needed to explain this relationship.
Optimization of the Merging Area after Toll
Authors: Lin Li , Su Liang , Chen Shaozhen , Zhang Yuanbiao
Published: January 2018

In this paper, we focus on the planning of the merging area after toll and have established an optimization model by means of nonlinear integer programming model. With the consideration of factors such as safety, cost, and throughput, we select indexes including traffic flow, vehicle speed, lane width and the number of lanes to calculate and determine the tollbooth and merging area, and depending on the situation, we built modification model and reconstruction model. Then, we select Delaware Memorial Bridge toll plaza as an example to evaluate the effectiveness of our solutions based on the optimal model. We apply the method of computer simulation to solve the model, and we find that some parameters with the fixed value such as forced exchange rate, average expected speed and gradient rate may affect the applicability of the model. Then, we carry out the sensitivity analysis with the three parameters to determine the scope of application of the model. Finally, we further discuss development direction of this model.
Prioritizing Solutions of Sovereign Debt Default in PIIGS
Authors: Ting Chien-Jung
Published: January 2018

The global economic recession in 2008 triggered an eruption of Europe sovereign debt defaults in Portugal, Italy, Ireland, Greece, and Spain (PIIGS), and these defaults originated from a social welfare expense burden and sovereign debt rollover. In this paper, we detect methods for eliminating the European sovereign debt crisis via the Delphi technique and the Analytic Hierarchy Process. Suggestions from experts include, respectively, “actively lessening government fiscal deficit,” ”lowering the sovereign debt of PIIGS,” and “strengthening the fiscal structure of Eurozone countries.” The empirical results correspond with the actual actions of the EMU, especially the reimbursement constraints on PIIGS by the European Central Bank. It is concluded that improving the nation’s fiscal structure is important, and the feasible ways to do so include reducing social welfare expense, levying more taxes on the middle class, and improving the quality of labor. Especially, enhancing a nation’s debt-credit ratio could increase solvency.
Turkish Secondary Education Students’ Perceptions of Justice and Their Experiences of Unjustice
Authors: Tarhan Sinem
Published: January 2018

The purpose of this study was to identify how secondary education students define the concept of justice, based on which criteria they define their experiences as just/unjust, what they see as the source of injustice, how they feel and how they behave when they face injustice.This study was designed as a qualitative research study. Open-ended questions were asked to the students and they were asked to give detailed answers. Descriptive analysis was used in analysing the collected data. The study group consisted of students studying at 9th, 10th, 11th and 12th grades in different types of high schools (Anatolian High School, Vocational School for Girls, Science High School). A total number of 268 high school students participated in the study. We used convenience sampling to choose the study group.The results of the study indicated that students defined the concept of justice with the “equality, equity non-discrimination, respect, rights and freedoms, conscience, rights, deciding the right, being fair and needs” concepts. The students see grades, school rules and non-communication they experience with their teachers and principals as unjust, so they point the school principals as the source of injustice. Besides, the students indicated that they had negative feelings when they experienced something that is not just but preferred to stay silent.
O que podemos aprender com a atual realidade da Atenção Primária inglesa? Considerações a partir da tradução de textos da British Journal of General Practice pela Revista Brasileira de Medicina de Família e Comunidade
Authors: Sarti Thiago Dias , Fontenelle Leonardo Ferreira
Published: January 2018

Neste editorial, apresentamos a nova sessão de textos traduzidos, fruto da parceria da Revista Brasileira de Medicina de Família e Comunidade com a British Journal of General Practice. Em 2017, optamos por traduzir textos que trouxessem para o Brasil reflexões sobre a atualidade da atenção primária inglesa, particularmente sobre a incorporação de tecnologias na prática dos médicos de família, a necessidade de maior conhecimento sobre a relação entre oferta, demanda e acesso aos serviços de saúde, bem como sobre os efeitos de políticas de pagamento por performance na prática dos profissionais de saúde. Tais reflexões são atuais para o contexto brasileiro, sugerindo a importância de maiores investimentos em inovação e produção de conhecimentos científicos para o fortalecimento da APS no país.
La recepción de la democracia ateniense en la filosofía política de Antoni Domènech: el sorteo y su trasfondo ético y antropologico
Authors: Vázquez García Francisco
Published: January 2018

En este artículo se analiza la recepción de la institución ateniense del sorteo en la filosofía política de Antoni Domènech (n. 1952). Tomando como referencia principal el libro De la ética a la política (1989), se examina la perspectiva de su autor sobre el trasfondo ético y antropológico del republicanismo antiguo, a partir de los conceptos de “razón erótica” y “tangente ática”. Por otra parte, utilizando la metodología de la sociología de la filosofía, se localiza su intervención en el campo filosófico español de la década de 1980. Por último, se estudia el modo en que la referencia a la filosofía antigua le sirve a Domènech para pronunciarse sobre el debate coetáneo en torno a la crisis de la razón moderna.
Behavior and biocompatibility of rabbit bone marrow mesenchymal stem cells with bacterial cellulosic membrane
Authors: Alencar Marcello Silva , Carvalho Yulla Klinger , Carvalho Camila Ernanda , Feitosa Matheus Tajra , Carvalho Fernando Aécio de Amorim , Viana Bartolomeu Cruz , Miglino Maria Angélica , Jozala Ângela Faustino , Carvalho Maria Acelina
Published: January 2018

Background. Tissue engineering has been shown to exhibit great potential for the creation of biomaterials capable of developing into functional tissues. Cellular expansion and integration depends on the quality and surface-determinant factors of the scaffold, which are required for successful biological implants. The objective of this research was to characterize and evaluate the in vitro characteristics of rabbit bone marrow mesenchymal stem cells (BM-MSCs) associated with a bacterial cellulose membrane (BCM). We assessed the adhesion, expansion, and integration of the biomaterial as well as its ability to induce macrophage activation. Finally, we evaluated the cytotoxicity and toxicity of the BCM.

Methods. Samples of rabbit bone marrow were collected. Mesenchymal stem cells were isolated from medullary aspirates to establish fibroblast colony-forming unit assays. Osteogenic, chondrogenic, and adipogenic differentiation was performed. Integration with the BCM was assessed by scanning electron microscopy at 1, 7, and 14 days. Cytotoxicity was assessed via the production of nitric oxide, and BCM toxicity was assessed with the MTT assay; phagocytic activity was also determined.

Results. The fibroblastoid colony-forming unit (CFU-F) assay showed cells with a fibroblastoid morphology organized into colonies, and distributed across the culture area surface. In the growth curve, two distinct phases, lag and log phase, were observed at 15 days. Multipotentiality of the cells was evident after induction of osteogenic, chondrogenic, and adipogenic lineages. Regarding the BM-MSCs’ bioelectrical integration with the BCM, BM-MSCs were anchored in the BCM in the first 24 h. On day 7 of culture, the cytoplasm was scattered, and on day 14, the cells were fully integrated with the biomaterial. We also observed significant macrophage activation; analysis of the MTT assay and the concentration of nitric oxide revealed no cytotoxicity of the biomaterial.

Conclusion. The BCM allowed the expansion and biointegration of bone marrow progenitor cells with a stable cytotoxic profile, thus presenting itself as a biomaterial with potential for tissue engineering.
Simulated Impact of Glacial Runoff on CO2 Uptake in the Gulf of Alaska
Authors: Pilcher Darren J. , Siedlecki Samantha A. , Hermann Albert J. , Coyle Kenneth O. , Mathis Jeremy T. , Evans Wiley
Published: January 2018

The Gulf of Alaska (GOA) receives substantial summer freshwater runoff from glacial meltwater. The alkalinity of this runoff is highly dependent on the glacial source and can modify the coastal carbon cycle. We use a regional ocean biogeochemical model to simulate CO2 uptake in the GOA under different alkalinity‐loading scenarios. The GOA is identified as a current net sink of carbon, though low‐alkalinity tidewater glacial runoff suppresses summer coastal carbon uptake. Our model shows that increasing the alkalinity generates an increase in annual CO2 uptake of 1.9–2.7 TgC/yr. This transition is comparable to a projected change in glacial runoff composition (i.e., from tidewater to land‐terminating) due to continued climate warming. Our results demonstrate an important local carbon‐climate feedback that can significantly increase coastal carbon uptake via enhanced air‐sea exchange, with potential implications to the coastal ecosystems in glaciated areas around the world.
On the Effects of Bremsstrahlung Radiation During Energetic Electron Precipitation
Authors: Xu Wei , Marshall Robert A. , Fang Xiaohua , Turunen Esa , Kero Antti
Published: January 2018

Precipitation of energetic particles into the Earth's atmosphere can significantly change the properties, dynamics, as well as the chemical composition of the upper and middle atmosphere. In this paper, using Monte Carlo models, we simulate, from first principles, the interaction of monoenergetic beams of precipitating electrons with the atmosphere, with particular emphasis on the process of bremsstrahlung radiation and its resultant ionization production and atmospheric effects. The pitch angle dependence of the ionization rate profile has been quantified: the altitude of peak ionization rate depends on the pitch angle by a few kilometers. We also demonstrate that the transport of precipitating electron energy in the form of bremsstrahlung photons leads to ionization at altitudes significantly lower than the direct impact ionization, as low as ∼20 km for 1 MeV precipitating electrons. Moreover, chemical modeling results suggest that the chemical effects in the atmosphere due to bremsstrahlung‐induced ionization production during energetic electron precipitation are likely insignificant.
Emerging methods in colorectal cancer screening
Authors: Ryan E J , Creagh E M
Published: January 2018

Gene-specific possibilities
Impact of genomics on the surgical management of melanoma
Authors: Ferguson P M , Long G V , Scolyer R A , Thompson J F
Published: January 2018

Background

Although surgery for early-stage melanoma offers the best chance of cure, recent advances in molecular medicine have revolutionized the management of late-stage melanoma, leading to significant improvements in clinical outcomes. Research into the genomic drivers of disease and cancer immunology has not only ushered in a new era of targeted and immune-based therapies for patients with metastatic melanoma, but has also provided new tools for monitoring disease recurrence and selecting therapeutic strategies. These advances present new opportunities and challenges to the surgeon treating patients with melanoma.

Methods

The literature was reviewed to evaluate diagnostic and therapeutic advances in the management of cutaneous melanoma, and to highlight the impact of these advances on surgical decision-making.

Results

Genomic testing is not required in the surgical management of primary melanoma, although it can provide useful information in some situations. Circulating nucleic acids from melanoma cells can be detected in peripheral blood to predict disease recurrence before it manifests clinically, but validation is required before routine clinical application. BRAF mutation testing is the standard of care for all patients with advanced disease to guide therapy, including the planning of surgery in adjuvant and neoadjuvant settings.

Conclusion

Surgery remains central for managing primary melanoma, and is an important element of integrated multidisciplinary care in advanced disease, particularly for patients with resectable metastases. The field will undergo further change as clinical trials address the relationships between surgery, radiotherapy and systemic therapy for patients with high-risk, early-stage and advanced melanoma.
Histopathological and molecular classification of colorectal cancer and corresponding peritoneal metastases
Authors: Ubink I , van Eden W J , Snaebjornsson P , Kok N F M , van Kuik J , van Grevenstein W M U , Laclé M M , Sanders J , Fijneman R J A , Elias S G , Borel Rinkes I H M , Aalbers A G J , Kranenburg O
Published: January 2018

Background

Patients with colorectal peritoneal carcinomatosis have a very poor prognosis. The recently developed consensus molecular subtype (CMS) classification of primary colorectal cancer categorizes tumours into four robust subtypes, which could guide subtype-targeted therapy. CMS4, also known as the mesenchymal subtype, has the greatest propensity to form distant metastases. CMS4 status and histopathological features of colorectal peritoneal carcinomatosis were investigated in this study.

Methods

Fresh-frozen tissue samples from primary colorectal cancer and paired peritoneal metastases from patients who underwent cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy were collected. Histopathological features were analysed, and a reverse transcriptase–quantitative PCR test was used to assess CMS4 status of all collected lesions.

Results

Colorectal peritoneal carcinomatosis was associated with adverse histopathological characteristics, including a high percentage of stroma in both primary tumours and metastases, and poor differentiation grade and high-grade tumour budding in primary tumours. Furthermore, CMS4 was significantly enriched in primary tumours with peritoneal metastases, compared with unselected stage I–IV tumours (60 per cent (12 of 20) versus 23 per cent; P = 0.002). The majority of peritoneal metastases (75 per cent, 21 of 28) were also classified as CMS4. Considerable intrapatient subtype heterogeneity was observed. Notably, 15 of 16 patients with paired tumours had at least one CMS4-positive tumour location.

Conclusion

Significant enrichment for CMS4 was observed in colorectal peritoneal carcinomatosis.
Recent Advances in Homogeneous Carbonylation Using CO2 as CO Surrogate
Authors: Wang Lu , Sun Wei , Liu Chao
Published: January 2018

Carbon dioxide is a sufficient and important carbon resource, which has been widely used as a C1 building block in synthetic chemistry. Carbonylations with CO are important processes in industry. However, due to the toxicity of CO, its storage and transport are problematic. Attentions are gradually focused on using other safe reagents to be the CO surrogates in carbonylation reactions. This review focuses on the summary of recent developments in using CO2 as a CO surrogate in homogeneous catalysis. Reductive processes by using H2, Si‐H, alcohols, etc and redox‐neutral processes are separately summarized.
Root reinforcement to soils provided by common Ethiopian highland plants for gully erosion control
Authors: Zegeye Assefa D. , Langendoen Eddy J. , Tilahun Seifu A. , Mekuria Wolde , Poesen Jean , Steenhuis Tammo S.
Published: January 2018

Grasses and trees are often used to stabilize gully banks. However, the effectiveness of such biological conservation measures has not been investigated for the Ethiopian highlands. This study investigates the reinforcement that plant roots may provide to strengthen gully banks in Ethiopia. The root systems of 26 indigenous and exotic plant species of 3 plant life forms (grasses, shrubs, and trees) were sampled, and root tensile strength and distribution were determined. The RipRoot model was used to quantify the additional cohesion derived from the plant roots. Among all tested roots, Eleusine floccifolia (grass), Tephrosia vogelii (tree), and Rosa abyssinica (shrub) had the strongest roots for each life form. The root volumetric ratio (root volume divided by soil volume) in the top 0.6 m of soil ranged from 0.03% to 0.46%. Roots of Digitaria abyssinica provided the maximum added cohesion (10.6 kPa) over this depth. For a given plant species, root volumetric ratio had a greater effect on additional cohesion than root tensile strength. Plant species with a fibrous root system provided greater additional cohesion values in the top 0.6 m (on average 3.4 vs. 1.7 kPa for tap root systems) and could potentially enhance gully bank stability for shallow gullies more than plants having a tap root system. To effectively rehabilitate larger gullies, plants should be integrated with other gully rehabilitation measures, such as regrading of gully banks and structural measures such as check dams to trap sediments, thereby reducing the effective gully bank height relative to rooting depth.
Enzymatic Inter‐Esterification of Binary Blends Containing Irvingia gabonensis Seed Fat to Produce Cocoa Butter Substitute
Authors: Yamoneka Juste , Malumba Paul , Lognay Georges , Béra François , Blecker Christophe , Danthine Sabine
Published: January 2018

In order to investigate Irvingia gabonensis seed fat (IGF) as a potential cocoa butter alternative (CBA), its melting behavior is first compared to that of cocoa butter (CB). It is then modified by blending 90% of this fat with 10% of a liquid oil either rapeseed oil (RO) or groundnut oil (GO) or palm super olein (PSO) or Dacryodes edulis pulp oil (DPO). Those blends are then enzymatically interesterified in order to improve their melting profiles. The binary blend that shows a similar profile with CB and palm kernel stearin (PKS) is chosen as the best potential new speciality fat. Compatibility between the new speciality fat and CB is evaluated by constructing phase diagrams from NMR and XRD data. The interesterified blends with 90% of IGF and 10% of DPO is chosen as the new speciality fat because its profiles is close to that of CB and shows similar characterics to PKS. The results indicate that the specialty fat produced from IGF and DPO could be used as CBS in confectionery industries (alone or mixed in low proportion with CB).

Practical Applications: Fractionnated and/or hydrogenated lauric fats are frequently used by confectionery industries to substitute CB. Results from this study demonstrate that an interesterified blend made of 90% IGF and 10% of DPO can be used also as CBS. The use of these two tropical oils (Irvingia gabonensis seeds fat and Dacryodes edulis pulp oil) as new sources of CBS constitutes a promizing way for their valorization at an industrial scale.

Irvingia gabonensis seed fat (IGF) is a naturel lauric fat source with a high quantity of lauric acid (≈37%). Its melting profile, which is similar to cocoa butter (CB), is too high for a direct use in its native state in confectionery application. When IGF is blend to Dacryodes edulis pulp oil and after enzymatically interesterified, its profile is close to that of CB. This result indicated that the interesterified blend can be used as cocoa butter subtitute in confectionery industries (alone or mixed in low proportion with CB).
Home range estimator method and GPS sampling schedule affect habitat selection inferences for wild turkeys
Authors: Cohen Bradley S. , Prebyl Thomas J. , Collier Bret A. , Chamberlain Michael J.
Published: January 2018

Understanding patterns in the spatial distribution of individuals in a population is a central question in ecology. Concurrent with advances in biotelemetry devices, development of home range estimator methods incorporating the temporal component of locational fixes are increasingly used to investigate these patterns at finer scales. However, these methods may necessitate sampling schedules that limit battery life and study period length. Practically, evaluating how home range estimator methods affect calculations of space use and habitat selection prior to deployment of biotelemetry devices could help researchers optimize data acquisition schedules. We quantified spatial overlap between a home range estimator using temporal information (dynamic Brownian bridge movement model [dBBMM]) and home range estimators not incorporating the temporal component of fixes (ad hoc and href kernel density estimator [KDE]) across differing sample schedules, and the resulting error in habitat selection ratios using data collected from wild turkeys (Meleagris gallopavo) equipped with Global Positioning Systems units in Texas, Georgia, South Carolina, and Louisiana, USA, during February–May 2015. When comparing ranges created from KDEs to dBBMM, commission errors were large (20–80%) and did not diminish with increased sampling rates. In contrast, omission error rate declined quicker and improvements were minimal when fix rates increased beyond 4/day. Compared with ranges estimated with dBBMM, KDEs poorly defined the spatial bearings of an individual's range, overestimated areas of use, underestimated areas avoided, and showed different patterns of habitat selection. Our results suggest home range estimator methods incorporating temporal information seem capable of estimating ranges encompassing nearly all area used by an individual and should be used even at relatively low‐frequency collection schedules to assess home ranges of wild turkeys. If researchers are interested in describing habitat selection of wild turkeys, we recommend a sampling schedule of ≤1 location/hour during daytime and dBBMM for range estimation. © 2018 The Wildlife Society.
Spin Hall photoconductance in a three-dimensional topological insulator at room temperature
Authors: Seifert Paul , Vaklinova Kristina , Ganichev Sergey , Kern Klaus , Burghard Marko , Holleitner Alexander W.
Published: January 2018

Three-dimensional topological insulators are a class of Dirac materials, wherein strong spin-orbit coupling leads to two-dimensional surface states. The latter feature spin-momentum locking, i.e., each momentum vector is associated with a spin locked perpendicularly to it in the surface plane. While the principal spin generation capability of topological insulators is well established, comparatively little is known about the interaction of the spins with external stimuli like polarized light. We observe a helical, bias-dependent photoconductance at the lateral edges of topological Bi2Te2Se platelets for perpendicular incidence of light. The same edges exhibit also a finite bias-dependent Kerr angle, indicative of spin accumulation induced by a transversal spin Hall effect in the bulk states of the Bi2Te2Se platelets. A symmetry analysis shows that the helical photoconductance is distinct to common longitudinal photoconductance and photocurrent phenomena, but consistent with optically injected spins being transported in the side facets of the platelets.
A hypoxia- and telomerase-responsive oncolytic adenovirus expressing secretable trimeric TRAIL triggers tumour-specific apoptosis and promotes viral dispersion in TRAIL-resistant glioblastoma
Authors: Oh Eonju , Hong JinWoo , Kwon Oh-Joon , Yun Chae-Ok
Published: January 2018

Glioblastoma is a highly aggressive and malignant type of cancer that is apoptosis resistant and difficult to cure by conventional cancer therapies. In this regard, an oncolytic adenovirus that selectively targets the tumour tissue and induces tumour cell lysis is a promising treatment option. We designed and constructed a hypoxia-responsive and cancer-specific modified human telomerase reverse transcriptase (H5CmTERT) promoter to drive replication of an oncolytic adenovirus (H5CmTERT-Ad). To enhance the anti-tumour efficacy of H5CmTERT-Ad against malignant glioblastoma, we also generated an H5CmTERT-Ad expressing secretable trimeric tumour necrosis factor-related apoptosis-inducing ligand (H5CmTERT-Ad/TRAIL). H5CmTERT promoter-regulated oncolytic adenoviruses showed cancer-specific and superior cell-killing effect in contrast to a cognate control oncolytic adenovirus replicating under the control of the endogenous adenovirus promoter. The cancer cell-killing effects of H5CmTERT-Ad and H5CmTERT-Ad/TRAIL were markedly higher during hypoxia than normoxia owing to hypoxia responsiveness of the promoter. H5CmTERT-Ad/TRAIL showed more potent anti-tumour efficacy than H5CmTERT-Ad did in a xenograft model of TRAIL-resistant subcutaneous and orthotopic glioblastoma through superior induction of apoptosis and more extensive virus distribution in the tumour tissue. Altogether, our findings show that H5CmTERT-Ad/TRAIL can promote dispersion of an oncolytic adenovirus through robust induction of apoptosis in a highly TRAIL-resistant glioblastoma.
Group-I PAKs-mediated phosphorylation of HACE1 at serine 385 regulates its oligomerization state and Rac1 ubiquitination
Authors: Acosta Maria I. , Urbach Serge , Doye Anne , Ng Yuen-Wai , Boudeau Jérôme , Mettouchi Amel , Debant Anne , Manser Edward , Visvikis Orane , Lemichez Emmanuel
Published: January 2018

The regulation of Rac1 by HACE1-mediated ubiquitination and proteasomal degradation is emerging as an essential element in the maintenance of cell homeostasis. However, how the E3 ubiquitin ligase activity of HACE1 is regulated remains undetermined. Using a proteomic approach, we identified serine 385 as a target of group-I PAK kinases downstream Rac1 activation by CNF1 toxin from pathogenic E. coli. Moreover, cell treatment with VEGF also promotes Ser-385 phosphorylation of HACE1. We have established in vitro that HACE1 is a direct target of PAK1 kinase activity. Mechanistically, we found that the phospho-mimetic mutant HACE1(S385E), as opposed to HACE1(S385A), displays a lower capacity to ubiquitinate Rac1 in cells. Concomitantly, phosphorylation of Ser-385 plays a pivotal role in controlling the oligomerization state of HACE1. Finally, Ser-385 phosphorylated form of HACE1 localizes in the cytosol away from its target Rac1. Together, our data point to a feedback inhibition of HACE1 ubiquitination activity on Rac1 by group-I PAK kinases.
Publisher Correction: Determination of total and unbound docetaxel in plasma by ultrafiltration and UPLC-MS/MS: application to pharmacokinetic studies
Authors: Sheu Ming-Thau , Wu Chen-Yuan , Su Chia-Yu , Ho Hsiu-O
Published: January 2018

A correction to this article has been published and is linked from the HTML version of this paper. The error has been fixed in the paper.
Modular design of optically controlled protein affinity reagents
Authors: Babalhavaeji A. , Woolley G. A.
Published: January 2018

Reversible, optical control of a generalizable protein affinity reagent.
[UCl4(HCN)4] – a hydrogen cyanide complex of uranium tetrachloride
Authors: Rudel S. S. , Pietzonka C. , Hoelzel M. , Kraus F.
Published: January 2018

The reaction of uranium tetrachloride with anhydrous liquid hydrogen cyanide yields a turquoise microcrystalline powder of tetrachloridotetraformonitrileuranium(iv), [UCl4(HCN)4].
Inducing chemical reactivity on specific sites of a molecule using the Coulomb interaction exerted by a low energy electron
Authors: Davis Daly , Sajeev Y.
Published: January 2018

Site-specificity in the resonant attachment of low energy electrons to molecular targets is used for engineering chemical reactivity.
A simple microfluidic platform for the partial treatment of insuspendable tissue samples with orientation control
Authors: Fan Anthony , Tofangchi Alireza , De Venecia Matthew , Saif Taher
Published: January 2018

We introduce a microfluidic platform that mounts directly onto a living sample to perform partial treatment of single exposed axons.
Heterocyclic amino acids as fluorescent reporters for transition metals: synthesis and evaluation of novel furyl-benzoxazol-5-yl-l-alanines
Authors: Ferreira Rosa Cristina M. , M. Raposo Maria Manuela , Costa Susana P. G.
Published: January 2018

Novel benzoxazol-5-yl-l-alanines with heterocyclic pendants were synthesized and investigated as fluorescent reporters for metal cations through spectrofluorimetric titrations.
Dissimilitude behaviour of Cu2O nano-octahedra and nano-cubes towards photo- and electrocatalytic activities
Authors: Mukherjee Indrani , Das Sushanta K. , Jena Bikash Kumar , Saha Rajnarayan , Chatterjee Sriparna
Published: January 2018

Nano-octahedra are photocatalytically active for the removal of organic contaminants of water, whereas nanocubes are electrocatalytically active towards oxygen reduction reactions.
On the copper(ii) binding of asymmetrically functionalized tripodal peptides: solution equilibrium, structure, and enzyme mimicking
Authors: Dancs Ágnes , Selmeczi Katalin , May Nóra V. , Gajda Tamás
Published: January 2018

The increasing histidyl functionalisation of tren results in the fundamental impact on the structure, stability and catecholase activity of its copper(ii) complexes.
LINC00152 down-regulated miR-193a-3p to enhance MCL1 expression and promote gastric cancer cells proliferation
Authors: Huang Yong , Luo Hui , Li Fang , Yang Yun’e , Ou Guangsheng , Ye Xiaolong , Li Nianchu
Published: January 2018

The present work aimed to probe into the effect of long non-coding RNA (lncRNA) LINC00152 on gastric cancer (GC) cells proliferation by regulating miR-193a-3p and its target gene MCL1. Transfected si-LINC00152 was used to down-regulate LINC00152, and cells proliferation was measured by the cell counting kit-8 (CCK-8) assay. Cell apoptosis and cell cycle were analyzed by flow cytometry (FCM). Besides, we also detected the potential functional effects of differential expression of LINC00152 in vivo using nude mouse xenograft model. We overexpressed and downexpressed miR-193a-3p to study the in vitro effect of miR-193a-3p on GC cells proliferation and vitality. And MCL1 was silenced by shRNA to investigate the effect of MCL1 on proliferation of GC cells. In this research, LINC00152 was proven to have a higher expression level in GC tissues than in the adjacent normal tissues. GC cells proliferation was inhibited after LINC00152 was down-regulated. LINC00152 inhibited the expression of miR-193a-3p, which negatively regulated MCL1. In addition, GC cells proliferation was inhibited by cell transfection with shRNA-MCL1, and enhanced by transfection with miR-193a-3p mimics. Our study suggested that LINC00152 was overexpressed in GC tissues, and it down-regulated miR-193a-3p to enhance MCL1 expression thereby promoting GC cells proliferation.
Antenna array in 3D to improve tracking of small HF RFID tag
Authors: Miyassa Salhi , Benamara Megdouda , Grzeskowiak Marjorie , Lissorgues Gaëlle , Diet Antoine , Le Bihan Yann
Published: January 2018

This paper presents an improvement of small RFID tags detection in HF near field, whatever their lateral and angular misalignments, using a complementary sub‐coils reader antenna, enhanced by coplanar weakly‐coupled resonators, and conformed on a 3D tube. The key ideas of detection improvement are: (i) modification of B‐field vector distribution with the complementary coils above the common edge of consecutive loops; (ii) increase of B‐field vector diversity and magnitude distribution by a 3D structure conformed on the tube, by realising 2 pairs of Identical Coaxial Loops (ICLs) with face‐to‐face sub‐coils in forward current, and (iii) enhancement of B‐field magnitude distribution by resonators included in the complementary sub‐coils. Numerical simulations are carried out using High Frequency Structure Simulator (HFSS). The studied figure‐of‐merit is the mutual inductance between the tag and the reader coil. Results are reported for the 4 planar complementary sub‐coils, the previous structure conformed on the tube and for the structure in which RCL resonators are added in the 3 planar complementary sub‐coils. Experimental detection range measurements of each fabricated structure drives to the enhancement of the 3D complementary 4 × 3 sub‐coils structure with weakly‐coupled RLC resonators in each‐sub‐coil in terms of read‐out distance and detection surface area.
Fahrtauglichkeit bei Leichter Kognitiver Störung und Demenz
Authors: Schmidtke Klaus
Published: January 2018

Exekutive Leistungen, visuell-räumliches Denken und Verhaltenskontrolle sind für das sichere Autofahren wesentliche geistige Leistungen. Bei
Demenz und Leichter Kognitiver Störung treten Defizite dieser Leistungen auf, die sich zu altersbedingten Defiziten addieren. Sie können
durch eine angepasste Fahrweise nicht immer ausreichend kompensiert werden und führen ggf. schon im frühen Stadium zur Aufhebung der
Fahrtauglichkeit. Neurologen und Psychiater kommt eine wichtige Rolle bei der Untersuchung, Aufklärung und ggf. Aussprache eines ärztlichen
Fahrverbotes zu. Fehler und Unterlassungen können hier unter Umständen juristische Konsequenzen nach sich ziehen. Der vorliegende Beitrag
stellt die relevanten Erkrankungen und die mit ihnen assoziierten kognitiven Störungen dar, gibt Empfehlungen für die neuropsychologische
Untersuchung und die Kommunikation mit Patienten und Angehörigen.
Analytic methods to find beating transitions of asymmetric Gaussian beams in GNLS equations
Authors: Ianetz David , Schiff Jeremy
Published: January 2018

In a simple model of propagation of asymmetric Gaussian beams in nonlinear waveguides, described by a reduction to ordinary differential equations of generalized nonlinear Schrödinger equations with cubic-quintic (CQ) and saturable (SAT) nonlinearities and a graded-index profile, the beam widths exhibit two different types of beating behavior, with transitions between them. We present an analytic model to explain these phenomena, which originate in a 1:1 resonance in a 2 degree-of-freedom Hamiltonian system. We show how small oscillations near a fixed point close to 1:1 resonance in such a system can be approximated using an integrable Hamiltonian and, ultimately, a single first order differential equation. In particular, the beating transitions can be located from coincidences of roots of a pair of quadratic equations, with coefficients determined (in a highly complex manner) by the internal parameters and initial conditions of the original system. The results of the analytic model agree with the numerics of the original system over large parameter ranges, and allow new predictions that can be verified directly. In the CQ case, we identify a band of beam energies for which there is only a single beating transition (as opposed to 0 or 2) as the eccentricity is increased. In the SAT case, we explain the sudden (dis)appearance of beating transitions for certain values of the other parameters as the grade-index is changed.
Note: Low temperature calibration of a commercial differential scanning calorimeter
Authors: Berberian John G.
Published: January 2018

A method for a direct calibration of temperature for a commercial differential scanning calorimeter is presented. The advantage of this calibration method is that it can be done for any number of selected temperatures and is not dependent on standards of known melting points in the temperature range of interest. The calibration presented in this note is for the temperature range from 91 K to 273 K, the temperature range of interest, but the range can easily be extended.
Broadband nonlinear optical response of monolayer MoSe2 under ultrafast excitation
Authors: Nie Zhonghui , Trovatello Chiara , Pogna Eva A. A. , Dal Conte Stefano , Miranda Paulo B. , Kelleher Edmund , Zhu Chunhui , Turcu Ion Crisitan Edmond , Xu Yongbing , Liu Kaihui , Cerullo Giulio , Wang Fengqiu
Published: January 2018

Due to their strong light-matter interaction, monolayer transition metal dichalcogenides (TMDs) have proven to be promising candidates for nonlinear optics and optoelectronics. Here, we characterize the nonlinear absorption of chemical vapour deposition (CVD)-grown monolayer MoSe2 in the 720–810 nm wavelength range. Surprisingly, despite the presence of strong exciton resonances, monolayer MoSe2 exhibits a uniform modulation depth of ∼80 ± 3% and a saturation intensity of ∼2.5 ± 0.4 MW/cm2. In addition, pump-probe spectroscopy is performed to confirm the saturable absorption and reveal the photocarrier relaxation dynamics over hundreds of picoseconds. Our results unravel the unique broadband nonlinear absorptive behavior of monolayer MoSe2 under ultrafast excitation and highlight the potential of using monolayer TMDs as broadband ultrafast optical switches with customizable saturable absorption characteristics.
Negative stiffness honeycombs as tunable elastic metamaterials
Authors: Goldsberry Benjamin M. , Haberman Michael R.
Published: January 2018

Acoustic and elastic metamaterials are media with a subwavelength structure that behave as effective materials displaying atypical effective dynamic properties. These material systems are of interest because the design of their sub-wavelength structure allows for direct control of macroscopic wave dispersion. One major design limitation of most metamaterial structures is that the dynamic response cannot be altered once the microstructure is manufactured. However, the ability to modify wave propagation in the metamaterial with an external stimulus is highly desirable for numerous applications and therefore remains a significant challenge in elastic metamaterials research. In this work, a honeycomb structure composed of a doubly periodic array of curved beams, known as a negative stiffness honeycomb (NSH), is analyzed as a tunable elastic metamaterial. The nonlinear static elastic response that results from large deformations of the NSH unit cell leads to a large variation in linear elastic wave dispersion associated with infinitesimal motion superposed on the externally imposed pre-strain. A finite element model is utilized to model the static deformation and subsequent linear wave motion at the pre-strained state. Analysis of the slowness surface and group velocity demonstrates that the NSH exhibits significant tunability and a high degree of anisotropy which can be used to guide wave energy depending on static pre-strain levels. In addition, it is shown that partial band gaps exist where only longitudinal waves propagate. The NSH therefore behaves as a meta-fluid, or pentamode metamaterial, which may be of use for applications of transformation elastodynamics such as cloaking and gradient index lens devices.