bluuebunny/crossref_metadata_2025 huggingface dataset:
Sequential Learning of Principal Curves: Summarizing Data Streams on the Fly
Authors: Li Le , Guedj Benjamin
Published: November 2021

When confronted with massive data streams, summarizing data with dimension reduction methods such as PCA raises theoretical and algorithmic pitfalls. A principal curve acts as a nonlinear generalization of PCA, and the present paper proposes a novel algorithm to automatically and sequentially learn principal curves from data streams. We show that our procedure is supported by regret bounds with optimal sublinear remainder terms. A greedy local search implementation (called slpc, for sequential learning principal curves) that incorporates both sleeping experts and multi-armed bandit ingredients is presented, along with its regret computation and performance on synthetic and real-life data.
Entropy-Based Shear Stress Distribution in Open Channel for All Types of Flow Using Experimental Data
Authors: Choo Yeon-Moon , Jeon Hae-Seong , Seo Jong-Cheol
Published: November 2021

Korean river design standards set general design standards for rivers and river-related projects in Korea, which systematize the technologies and methods involved in river-related projects. This includes measurement methods for parts necessary for river design, but does not include information on shear stress. Shear stress is one of the factors necessary for river design and operation. Shear stress is one of the most important hydraulic factors used in the fields of water, especially for artificial channel design. Shear stress is calculated from the frictional force caused by viscosity and fluctuating fluid velocity. Current methods are based on past calculations, but factors such as boundary shear stress or energy gradient are difficult to actually measure or estimate. The point velocity throughout the entire cross-section is needed to calculate the velocity gradient. In other words, the current Korean river design standards use tractive force and critical tractive force instead of shear stress because it is more difficult to calculate the shear stress in the current method. However, it is difficult to calculate the exact value due to the limitations of the formula to obtain the river factor called the tractive force. In addition, tractive force has limitations that use an empirically identified base value for use in practice. This paper focuses on the modeling of shear-stress distribution in open channel turbulent flow using entropy theory. In addition, this study suggests a shear stress distribution formula, which can easily be used in practice after calculating the river-specific factor T. The tractive force and critical tractive force in the Korean river design standards should be modified by the shear stress obtained by the proposed shear stress distribution method. The present study therefore focuses on the modeling of shear stress distribution in an open channel turbulent flow using entropy theory. The shear stress distribution model is tested using a wide range of forty-two experimental runs collected from the literature. Then, an error analysis is performed to further evaluate the accuracy of the proposed model. The results reveal a correlation coefficient of approximately 0.95–0.99, indicating that the proposed method can estimate shear-stress distribution accurately. Based on this, the results of the distribution of shear stress after calculating the river-specific factors show a correlation coefficient of about 0.86 to 0.98, which suggests that the equation can be applied in practice.
Operation of Distributed Battery Considering Demand Response Using Deep Reinforcement Learning in Grid Edge Control
Authors: Li Wenying , Tang Ming , Zhang Xinzhen , Gao Danhui , Wang Jian
Published: November 2021

Battery energy storage systems (BESSs) are able to facilitate economical operation of the grid through demand response (DR), and are regarded as the most significant DR resource. Among them, distributed BESS integrating home photovoltaics (PV) have developed rapidly, and account for nearly 40% of newly installed capacity. However, the use scenarios and use efficiency of distributed BESS are far from sufficient to be able to utilize the potential loads and overcome uncertainties caused by disorderly operation. In this paper, the low-voltage transformer-powered area (LVTPA) is firstly defined, and then a DR grid edge controller was implemented based on deep reinforcement learning to maximize the total DR benefits and promote three-phase balance in the LVTPA. The proposed DR problem is formulated as a Markov decision process (MDP). In addition, the deep deterministic policy gradient (DDPG) algorithm is applied to train the controller in order to learn the optimal DR strategy. Additionally, a life cycle cost model of the BESS is established and implemented in the DR scheme to measure the income. The numerical results, compared to deep Q learning and model-based methods, demonstrate the effectiveness and validity of the proposed method.
Synergies between Renewable Energy and Flexibility Investments: A Case of a Medium-Sized Industry
Authors: Wanapinit Natapon , Thomsen Jessica
Published: November 2021

Climate and energy policies are tools used to steer the development of a sustainable economy supplied by equally sustainable energy systems. End-users should plan their investments accounting for future policies, such as incentives for system-oriented consumption, emission prices and hydrogen economy, to ensure long-term competitiveness. In this work, the utilization of variable renewable energy and flexibility potentials in a case study of an aggregate industry is investigated. An energy concept considering PV and battery expansion, flexible production, fuel cell electric trucks (FCEV) and hydrogen production is proposed, and analysed under expected techno-economic conditions and policies of 2030 using an energy system optimization model. Under this concept, total costs and emissions are reduced by 14% and 70%, respectively, compared to the business-as-usual system. The main benefit of PV investment is the lowered electricity procurement. Flexibility from schedulable manufacturing and hydrogen production increases not only the self-consumption of PV generation from 51% to 80% but also the optimal PV capacity by 41%. Despite the expected cost reduction and efficiency improvement, FCEV is still not competitive to diesel trucks due to higher investment and fuel prices, i.e., its adoption increases the costs by 8%. However, this is resolved when hydrogen can be produced from own surplus electricity generation. Our findings reveal synergistic effects between different potentials and the importance of enabling local business models, e.g., regional hydrogen production and storage services. The SWOT analysis of the proposed concept shows that the pursuit of sustainability via new technologies entails new opportunities and risks. Lastly, end-users and policymakers are advised to plan their investments and supports towards integration of multiple application, consumption sectors and infrastructure.
A Decentralized Passive Islanding Detection Method Based on the Variations of Estimated Droop Characteristics
Authors: Lopez Juan Roberto , Ibarra Luis , Ponce Pedro , Molina Arturo
Published: November 2021

A microgrid including distributed generators can operate connected to the main electrical network or in an isolated manner, referred to as island operation. The transition between both states can occur voluntarily, but a disconnection can also happen unexpectedly. The associated transients can be harmful to the grid, and compensating actions must be triggered to avoid service interruption, preserve power quality, and minimize the possibility of faults; island detection methods are essential to this end. Such techniques typically depend on communication networks or on the introduction of minor electrical disturbances to identify and broadcast unexpected islanding events. However, local energy resources are distributed, variable, and are expected to be integrated in a plug-and-play manner; then, conventional island detection strategies can be ineffective as they rely on specific infrastructure. To overcome those problems, this work proposes a straightforward, distributed island detection technique only relying on local electrical measurements, available at the output of each generating unit. The proposed method is based on the estimated power-frequency ratio, associated with the stiffness of the grid. A “stiffness change” effectively reveals island operating conditions, discards heavy load variations, and enables independent (distributed) operation. The proposal was validated through digital simulations and an experimental test-bed. Results showed that the proposed technique can effectively detect island operation at each generating unit interacting in the microgrid. Moreover, it was about three times faster than other reported techniques.
Probabilistic Assessment and Uncertainty Analysis of CO2 Storage Capacity of the Morrow B Sandstone—Farnsworth Field Unit
Authors: Asante Jonathan , Ampomah William , Rose-Coss Dylan , Cather Martha , Balch Robert
Published: November 2021

This paper presents probabilistic methods to estimate the quantity of carbon dioxide (CO2) that can be stored in a mature oil reservoir and analyzes the uncertainties associated with the estimation. This work uses data from the Farnsworth Field Unit (FWU), Ochiltree County, Texas, which is currently undergoing a tertiary recovery process. The input parameters are determined from seismic, core, and fluid analyses. The results of the estimation of the CO2 storage capacity of the reservoir are presented with both expectation curve and log probability plot. The expectation curve provides a range of possible outcomes such as the P90, P50, and P10. The deterministic value is calculated as the statistical mean of the storage capacity. The coefficient of variation and the uncertainty index, P10/P90, is used to analyze the overall uncertainty of the estimations. A relative impact plot is developed to analyze the sensitivity of the input parameters towards the total uncertainty and compared with Monte Carlo. In comparison to the Monte Carlo method, the results are practically the same. The probabilistic technique presented in this paper can be applied in different geological settings as well as other engineering applications.
Optimal Placement of PMU to Enhance Supervised Learning-Based Pseudo-Measurement Modelling Accuracy in Distribution Network
Authors: Lee Kyung-Yong , Park Jung-Sung , Kim Yun-Su
Published: November 2021

This paper introduces a framework for optimal placement (OP) of phasor measurement units (PMUs) using metaheuristic algorithms in a distribution network. The voltage magnitude and phase angle obtained from PMUs were selected as the input variables for supervised learning-based pseudo-measurement modeling that outputs the voltage magnitude and phase angle of the unmeasured buses. For three, four, and five PMU installations, the metaheuristic algorithms explored 2000 combinations, corresponding to 40.32%, 5.56%, and 0.99% of all placement combinations in the 33-bus system and 3.99%, 0.25%, and 0.02% in the 69-bus system, respectively. Two metaheuristic algorithms, a genetic algorithm and particle swarm optimization, were applied; the results of the techniques were compared to random search and brute-force algorithms. Subsequently, the effects of pseudo-measurements based on optimal PMU placement were verified by state estimation. The state estimation results were compared among the pseudo-measurements generated by the optimal PMU placement, worst PMU placement, and load profile (LP). State estimation results based on OP were superior to those of LP-based pseudo-measurements. However, when pseudo-measurements based on the worst placement were used as state variables, the results were inferior to those obtained using the LP.
Main Carotenoids Produced by Microorganisms
Authors: Martínez-Cámara Sonia , Ibañez Ana , Rubio Sara , Barreiro Carlos , Barredo José-Luis
Published: November 2021

Carotenoids are the pigments present in plants, animals, and microorganisms which are responsible for a broad variety of colors found in nature. Their capacity as antioxidants mainly established their marketable success as health, food, and feed supplements, and cosmetics components. Currently, chemical synthesis dominates the worldwide market; however, due to the high biological value of natural carotenoids, the production scheme is moving towards microbial production as a profitable alternative.
Production of Bioethanol—A Review of Factors Affecting Ethanol Yield
Authors: Tse Timothy J. , Wiens Daniel J. , Reaney Martin J. T.
Published: November 2021

Fossil fuels are a major contributor to climate change, and as the demand for energy production increases, alternative sources (e.g., renewables) are becoming more attractive. Biofuels such as bioethanol reduce reliance on fossil fuels and can be compatible with the existing fleet of internal combustion engines. Incorporation of biofuels can reduce internal combustion engine (ICE) fleet carbon dioxide emissions. Bioethanol is typically produced via microbial fermentation of fermentable sugars, such as glucose, to ethanol. Traditional feedstocks (e.g., first-generation feedstock) include cereal grains, sugar cane, and sugar beets. However, due to concerns regarding food sustainability, lignocellulosic (second-generation) and algal biomass (third-generation) feedstocks have been investigated. Ethanol yield from fermentation is dependent on a multitude of factors. This review compares bioethanol production from a range of feedstocks, and elaborates on available technologies, including fermentation practices. The importance of maintaining nutrient homeostasis of yeast is also examined. The purpose of this review is to provide industrial producers and policy makers insight into available technologies, yields of bioethanol achieved by current manufacturing practices, and goals for future innovation.
A Fast Preconditioned Semi-Implicit Difference Scheme for Strongly Nonlinear Space-Fractional Diffusion Equations
Authors: Huang Yu-Yun , Gu Xian-Ming , Gong Yi , Li Hu , Zhao Yong-Liang , Carpentieri Bruno
Published: November 2021

In this paper, we propose a semi-implicit difference scheme for solving one-dimensional nonlinear space-fractional diffusion equations. The method is first-order accurate in time and second-order accurate in space. It uses a fractional central difference formula and the backward Euler method to approximate its space and time derivatives, respectively. Stability and convergence properties of the proposed scheme are proved with the help of a discrete Grönwall inequality. Moreover, we extend the method to the solution of two-dimensional nonlinear models. A fast matrix-free implementation based on preconditioned Krylov subspace methods is presented for solving the discretized linear systems. The resulting fast preconditioned semi-implicit difference scheme reduces the memory requirement of conventional semi-implicit difference schemes from O(Ns2) to O(Ns) and the computational complexity from O(Ns3) to O(NslogNs) in each iterative step, where Ns is the number of space grid points. Experiments with two numerical examples are shown to support the theoretical findings and to illustrate the efficiency of our proposed method.
More General Weighted-Type Fractional Integral Inequalities via Chebyshev Functionals
Authors: Rahman Gauhar , Hussain Arshad , Ali Asad , Nisar Kottakkaran Sooppy , Mohamed Roshan Noor
Published: November 2021

The purpose of this research paper is first to propose the generalized weighted-type fractional integrals. Then, we investigate some novel inequalities for a class of differentiable functions related to Chebyshev’s functionals by utilizing the proposed modified weighted-type fractional integral incorporating another function in the kernel F(θ). For the weighted and extended Chebyshev’s functionals, we also propose weighted fractional integral inequalities. With specific choices of ϖ(θ) and F(θ) as stated in the literature, one may easily study certain new inequalities involving all other types of weighted fractional integrals related to Chebyshev’s functionals. Furthermore, the inequalities for all other type of fractional integrals associated with Chebyshev’s functionals with certain choices of ϖ(θ) and F(θ) are covered from the obtained generalized weighted-type fractional integral inequalities.
An Investigation into the Impact of a Glutaminase Inhibitor, Compound 968, on Nrf2 Signaling
Authors: Lei Wei , Kliebe Valentin M. , Chen Xin
Published: November 2021

Glutaminase is a critical enzyme that catalyzes the process of glutaminolysis for energy synthesis. Meanwhile, glutaminase also contributes to the pathological process of various diseases, such as cancer, neurodegenerative diseases, and inflammation. This leads to the discovery of glutaminase inhibitors for therapeutical uses. However, the mechanisms of the beneficial therapeutical effect of glutaminase inhibitors are still unclear. This pilot study aimed to determine the impact of a well-characterized glutaminase inhibitor, compound 968 (C968), on Nrf2 signaling. We performed molecular docking, luciferase assay, and quantitative PCR to determine the activation of Nrf2 and the expression of several Nrf2-related genes. These experiments found that C968 induced the Nrf2 activation and promoted the expression of Nrf2, heme oxygenase-1 (HO-1), and NAD(P)H Quinone Dehydrogenase-1 (NQO-1). All findings provide evidence that Nrf2 activation could be one of the mechanisms contributing to the therapeutical activity of C968, but more studies are warranted to further confirm this mechanism.
Development of Chocolates with Improved Lipid Profile by Replacing Cocoa Butter with an Oleogel
Authors: Alvarez María Dolores , Cofrades Susana , Espert María , Sanz Teresa , Salvador Ana
Published: November 2021

The reformulation of chocolates seeks to find innovative alternatives to cocoa butter (CB) that are more economical and adhere to nutritional recommendations to replace saturated fats with unsaturated ones. In this research, chocolates were elaborated by substituting CB with an oleogel (OG) formulated with hydroxypropyl methylcellulose (HPMC) as an entrapper of sunflower oil by using the foam-templated approach. Four different CB/OG blends were prepared and characterized as potential CB substitutes (100/0 control), at replacement levels of 30%, 50%, 70% and 100% (70/30, 50/50, 30/70 and 0/100 blends), and subsequently, CB/OG-based chocolates (CB/OG-Ch) were formulated (100/0-Ch, 70/30-Ch, 50/50-Ch, 30/70-Ch and 0/100-Ch). Both the CB/OG blends and the CB/OG-Ch counterparts were characterized by dynamic and stationary rheology, hardness, thermal parameters, microstructure, and oil-binding capacity; in addition, the lipid profile of the chocolates was analyzed, and a sensory analysis was performed. Increasing the OG proportion in the CB/OG blend weakens the rigidity and strength of the fat-crystal network conferred by the CB, and decreases both its viscoelasticity and thermal parameters, but the differences between all the different properties and parameters of the CB/OG-Ch samples diminished in presence of the other ingredients used in the chocolate formulation. Sensory analysis evidenced that it is possible to replace up to 70% of CB with the OG, although from a technological point of view a replacement level of 50% would seem more appropriate. As compared to 100/0-Ch, 50/50-Ch and 30/70-Ch involve saturated fat reductions of 55% and 37%, respectively.
In Silico Drug Screening Based Development of Novel Formulations for Onychomycosis Management
Authors: Fatima Mahak , Monawwar Sadia , Mohapatra Sradhanjali , Alex Thomson Santosh , Ahmed Abdulrahman , Taleuzzaman Mohamad , Ali Asgar , Ansari Mohammad Javed , Mirza Mohd. Aamir , Iqbal Zeenat
Published: November 2021

Onychomycosis is a prominent fungal infection that causes discoloration, thickening, and mutilation leading to the separation of the nail from the nail bed. Treatment modalities for onychomycosis may include oral, topical, or combination therapy with antifungals and at times may require chemical or surgical intervention. The burden of side effects of antifungals is enormous, and therefore using molecular docking-based drug selection in context with the target keratin protein would ensure better disease management. Ciclopirox, Amorolfine HCl, Efinaconazole, Tioconazole, and Tavaborole were submitted for assessment, revealing that Amorolfine HCl is the best fit. Consequently, two formulations (Nail lacquer and nanoemulgel) were developed from Amorolfine HCl to validate the in silico screening outcomes. The formulations were further fortified with over-the-counter ingredients vis-a-vis with vitamin E in nail lacquer and undecylenic acid in nanoemulgel for their prominent roles in improving nail health. Both the formulations were systematically designed, optimized, and characterized. Amorolfine HCl containing nanoemulgel (NEG) was developed using undecylenic acid as an oil phase and thioglycolic acid as a penetration enhancer. The quality parameters evaluated were particle size, the zeta potential for nanoemulsion (NE) (78.04 ± 4.724 nm and −0.7mV, respectively), in vitro cumulative drug release (96.74% for NE and 88.54% for NEG), and transungual permeation (about 73.49% for NEG and 54.81% for NE). Nail lacquer was evaluated for the drying time, non-volatile content, and blush test. In vitro cumulative drug release of the developed nail lacquer and comparator marketed formulations were around 81.5% and 75%, respectively. Similarly, the transungual drug permeation was 6.32 μg/cm2 and 5.89 μg/cm2, respectively, in 24 h. The in silico guided preparation of both formulations containing Amorolfine HCl and over the counter ingredients is amenable for therapeutic use against onychomycosis and will be evaluated in the in vivo model.
Spectrum of Genetic Diseases in Tunisia: Current Situation and Main Milestones Achieved
Authors: Mezzi Nessrine , Messaoud Olfa , Mkaouar Rahma , Zitouna Nadia , Romdhane Safa , Abdessalem Ghaith , Charfeddine Cherine , Maazoul Faouzi , Ouerteni Ines , Hamdi Yosr , Zaouak Anissa , Mrad Ridha , Abdelhak Sonia , Romdhane Lilia
Published: November 2021

Genetic diseases in Tunisia are a real public health problem given their chronicity and the lack of knowledge concerning their prevalence and etiology, and the high rates of consanguinity. Hence, we performed systematic reviews of the literature in order to provide a more recent spectrum of these disorders and to expose the challenges that still exist to tackle these kinds of diseases. A manual textual data mining was conducted using MeSH and PubMed databases. Collected data were classified according to the CIM-10 classification and the transmission mode. The spectrum of these diseases is estimated to be 589 entities. This suggests remarkable progress through the development of biomedical health research activities and building capacities. Sixty percent of the reported disorders are autosomal recessive, which could be explained by the high prevalence of endogamous mating. Congenital malformations (29.54%) are the major disease group, followed by metabolic diseases (22%). Sixty percent of the genetic diseases have a known molecular etiology. We also reported additional cases of comorbidity that seem to be a common phenomenon in our population. We also noticed that epidemiological data are scarce. Newborn and carrier screening was only limited to pilot projects for a few genetic diseases. Collected data are being integrated into a database under construction that will be a valuable decision-making tool. This study provides the current situation of genetic diseases in Tunisia and highlights their particularities. Early detection of the disease is important to initiate critical intervention and to reduce morbidity and mortality.
Sex Chromosomes and Master Sex-Determining Genes in Turtles and Other Reptiles
Authors: Thépot Dominique
Published: November 2021

Among tetrapods, the well differentiated heteromorphic sex chromosomes of birds and mammals have been highly investigated and their master sex-determining (MSD) gene, Dmrt1 and SRY, respectively, have been identified. The homomorphic sex chromosomes of reptiles have been the least studied, but the gap with birds and mammals has begun to fill. This review describes our current knowledge of reptilian sex chromosomes at the cytogenetic and molecular level. Most of it arose recently from various studies comparing male to female gene content. This includes restriction site-associated DNA sequencing (RAD-Seq) experiments in several male and female samples, RNA sequencing and identification of Z- or X-linked genes by male/female comparative transcriptome coverage, and male/female transcriptomic or transcriptome/genome substraction approaches allowing the identification of Y- or W-linked transcripts. A few putative master sex-determining (MSD) genes have been proposed, but none has been demonstrated yet. Lastly, future directions in the field of reptilian sex chromosomes and their MSD gene studies are considered.
Mitigation of Drought Damages by Exogenous Chitosan and Yeast Extract with Modulating the Photosynthetic Pigments, Antioxidant Defense System and Improving the Productivity of Garlic Plants
Authors: Abdelaal Khaled , Attia Kotb A. , Niedbała Gniewko , Wojciechowski Tomasz , Hafez Yaser , Alamery Salman , Alateeq Talal K. , Arafa Sally A.
Published: November 2021

Garlic is an important vegetable in terms of its economic value and also as a medicinal plant. In this study, chitosan (300 mM) and yeast extract (8 g/L) were used individually or in combination to improve the yields of garlic plants under drought conditions (i.e., 75% and 50% of the water they would normally receive from irrigation) for two seasons. Significant decreases in numbers of leaves per plant and plant height, plant dry weight, relative water content, and chlorophyll a and b concentrations were found in stressed garlic plants in both seasons. The greatest reductions in these characters were recorded in plants that received only 50% of the normal irrigation in both seasons. Levels of hydrogen peroxide, products of lipid peroxidation such as malondialdehyde, and superoxide, as well as percentages of electrolyte leakage, were elevated considerably and were signals of oxidative damage. The application of the yeast extract (8 g/L) or chitosan (300 mM) individually or in combination led to a remarkable increase in the most studied characters of the stressed garlic plants. The combination of yeast extract (8 g/L) plus chitosan (300 mM) led to increase plant height (44%), ascorbic acid levels (30.2%), and relative water content (36.8%), as well as the chlorophyll a (50.7%) and b concentrations (79%), regulated the proline content and levels of antioxidant enzymes in stressed garlic plants that received 75% of the normal irrigation, and this decreased the signs of oxidative stress (i.e., percentage of electrolyte leakage and levels of malondialdehyde, hydrogen peroxide, and superoxide).
Is Instrumental Compression Equally Effective and Comfortable for Physiotherapists and Physiotherapy Students than Manual Compression? A Comparative Cross-Sectional Study
Authors: Pérez-Palomares Sara , Jiménez-Sánchez Carolina , Serrano-Herrero Ignacio , Herrero Pablo , Calvo Sandra
Published: November 2021

The objective of this work is to compare the homogeneity of instrumental and manual compression during the simulation of a pressure release technique, measured with a dynamometer, as well as to evaluate the comparative degree of comfort by physiotherapists and physiotherapy students when performing this technique. Methods: A comparative cross-sectional study was carried out with physiotherapists (lecturers with clinical experience) and 4th year students of the Physiotherapy Degree at Universidad San Jorge. The amount of pressure performed and how it was maintained during 80 s with both techniques was analysed using a digital dynamometer. The degree of comfort was evaluated using a modified numeric rating scale, with higher values representing a higher degree of discomfort. Results: A total of 30 subjects participated. Significant differences were found between the techniques in terms of maintaining a constant pressure level for 80 s (p = 0.043). A statistically significant difference was found between both techniques in the period from 45 to 80 s. Regarding the degree of discomfort, the value obtained from the students’ responses was 4.67 (1.35) for the manual technique and 1.93 (0.88) for the instrumental technique. In the case of physiotherapists, the comfort was 4.87 (2.13) for the manual technique and 3.33 (1.54) for the instrumental technique. Conclusion: The sustained manual compression necessary in manual pressure release techniques in the treatment of myofascial trigger points can be performed with assistive tools that guarantee a uniform compression maintained throughout the development of the technique and are more comfortable for physiotherapists.
Short-Term Cumulative Exposure to Ambient Traffic-Related Black Carbon and Blood Pressure: MMDA Traffic Enforcers’ Health Study
Authors: Regencia Zypher Jude G. , Dalmacion Godofreda V. , Ligsay Antonio D. , Baja Emmanuel S.
Published: November 2021

Exposure to traffic-related air pollution is linked with acute alterations in blood pressure (BP). We examined the cumulative short-term effect of black carbon (BC) exposure on systolic (SBP) and diastolic (DBP) BP and assessed effect modification by participant characteristics. SBP and DBP were repeatedly measured on 152 traffic enforcers. Using a linear mixed-effects model with random intercepts, quadratic (QCDL) and cubic (CCDL) constrained distributed lag models were fitted to estimate the cumulative effect of BC concentration on SBP and DBP during the 10 hours (daily exposure) and 7 days (weekly exposure) before the BP measurement. Ambient BC was related to increased BP with QCDL models. An interquartile range change in BC cumulative during the 7 days before the BP measurement was associated with increased BP (1.2% change in mean SBP, 95% confidence interval (CI), 0.1 to 2.3; and 0.5% change in mean DBP, 95% CI, −0.8 to 1.7). Moreover, the association between the 10-h cumulative BC exposure and SBP was stronger for female (4.0% change, 95% CI: 2.1–5.9) versus male and for obese (2.9% change, 95% CI: 1.0–4.8) vs. non-obese traffic enforcers. Short-term cumulative exposure to ambient traffic-related BC could bring about cardiovascular diseases through mechanisms involving increased BP.
The Effect of Abusive Supervision on Safety Behaviour: A Moderated Mediation Model
Authors: Zhang Xinyong , Sun Zhenzhen , Niu Zhaoxiang , Sun Yijing , Wang Dawei
Published: November 2021

Leadership behavior has an impact on the behavior of employees. Previous studies have mainly studied the impact of positive leadership behaviors on employees’ behaviors, but there is an absence of research on the impact of negative leadership behaviours (abusive supervision) on safety behaviours (including safety participation and safety compliance). In this study, 599 front-line employees in the petrochemical industry were selected as subjects. Abusive supervision, safety behaviour, safety motivation and a conscientiousness questionnaire were used as measurements to explore the relationship between abusive supervision and employee safety behaviors, and to further explore the roles of safety motivation, conscientiousness and the relationship between them. This study found that abusive supervision is negatively related to employee safety behaviours (safety compliance and safety participation); that safety motivation plays a mediating role in the relationship between abusive supervision and employees’ safety behavior; and that conscientiousness moderates the role of safety motivation between the relationship of abusive supervision and employees’ safety behaviour. With a higher level of conscientiousness, the indirect relationship between abusive supervision and employee safety behaviours is weaker. Finally, we discuss the theoretical and practical significance of these findings for abusive supervision and the management of safety behaviours.
Circumstances and Consequences of Violence-Related Injuries Presenting at Hospital. A Study at the Pediatric Emergency and Forensic Medicine Units of Maputo Central Hospital, Mozambique
Authors: Nhassengo Sérgio Keita , Matsinhe Stela Ocuane , Jethá Eunice , Laflamme Lucie
Published: November 2021

Rates of violence against children are high in Sub-Saharan Africa and information is scarce on the resulting injuries. This study investigates sex-related differences in the circumstances and consequences of sexual and physical violence in the Mozambican context. Hospital records from 2019 at the pediatric emergency and forensic medicine units of Maputo Central Hospital were scrutinized using a standardized form. Of the 321 cases identified, 60% resulted from sexual violence. Girls represented 86.4% of the victims of sexual violence and boys, 66.1% of those from physical violence. Being injured in a familiar environment and by a parent, a relative, or someone known was strikingly common. The injury pattern varied by form of violence and sex of the child. About half of the injuries sustained by physical violence were minor/superficial. Severe injuries requiring hospitalization (33% in total) and some specialized care (27% in total) were mainly sustained by girl victims of sexual violence. While circumstances and consequences of violence-related injuries have several similarities, being severely injured is more typical of girl victims of sexual violence. Besides medical care, hospital services in Mozambique must be prepared to offer pediatric victims of violence the necessary social care.
Identification of Groundwater Contamination in a Rapidly Urbanized Area on a Regional Scale: A New Approach of Multi-Hydrochemical Evidences
Authors: Bi Pan , Pei Lixin , Huang Guanxing , Han Dongya , Song Jiangmin
Published: November 2021

Efficient identification of groundwater contamination is a major issue in the context of groundwater use and protection. This study used a new approach of multi-hydrochemical indicators, including the Cl-Br mass ratio, the hydrochemical facies, and the concentrations of nitrate, phosphate, organic contaminants, and Pb in groundwater to identify groundwater contamination in the Pearl River Delta (PRD) where there is large scale urbanization. In addition, the main factors resulting in groundwater contamination in the PRD were also discussed by using socioeconomic data and principal component analysis. Approximately 60% of groundwater sites in the PRD were identified to be contaminated according to the above six indicators. Contaminated groundwaters commonly occur in porous and fissured aquifers but rarely in karst aquifers. Groundwater contamination in porous aquifers is positively correlated with the urbanization level. Similarly, in fissured aquifers, the proportions of contaminated groundwater in urbanized and peri-urban areas were approximately two times that in non-urbanized areas. Groundwater contamination in the PRD was mainly attributed to the infiltration of wastewater from township-village enterprises on a regional scale. In addition, livestock waste was also an important source of groundwater contamination in the PRD. Therefore, in the future, the supervision of the wastewater discharge of township-village enterprises and the waste discharge of livestock should be strengthened to protect against groundwater contamination in the PRD.
Physical Activity under Stress: A Perspective of HAPA and Individual Differences
Authors: Zhou Song , Li Linqian , Zhao Yan , Cao Yiheng , Peng Baozhong , Zheng Lei
Published: November 2021

Aims: Physical activity is an effective way for people to cope with stress. However, people often decrease their physical activity in response to stressors. Therefore, we aimed to understand the relationship between perceived stress and physical activity from an outcome expectancies perspective and investigated the moderating role of future orientation in this relationship. Methods: This study recruited 425 students who completed a three-wave survey at six-week intervals. A moderated mediation model was used to examine the mediating effects of outcome expectancies and the moderating effects of future orientation. Results: The results indicated that outcome expectancies mediated the relationship between perceived stress and physical activity. This relationship was moderated by future orientation. In particular, the mediating effects were significant for people with a high future orientation, but not for those with a low future orientation. Conclusion: Our results demonstrate the adaptive function of future orientation in response to general stress. Importantly, the link between perceived stress and reduced physical activity could be mitigated by encouraging people to focus on future consequences. Future studies should consider developing intervention strategies that help those struggling with stressful contexts.
Meat in a Seat: A Grounded Theory Study Exploring Moral Injury in Canadian Public Safety Communicators, Firefighters, and Paramedics
Authors: Smith-MacDonald Lorraine , Lentz Liana , Malloy David , Brémault-Phillips Suzette , Carleton R. Nicholas
Published: November 2021

The work of public safety personnel (PSP) is inherently moral; however, the ability of PSP to do what is good and right can be impeded and frustrated, leading to moral suffering. Left unresolved, moral suffering may develop into moral injury (MI) and potential psychological harm. The current study was designed to examine if MI is relevant to frontline public safety communicators, firefighters, and paramedics. Semi-structured interviews (n = 3) and focus groups (n = 3) were conducted with 19 participants (public safety communicators (n = 2); paramedics (n = 7); and firefighters (n = 10)). Interviews and focus groups were audio-recorded, transcribed, coded, and constantly compared in accordance with the grounded theory method. A conceptual theory of “frustrating moral expectations” emerged, with participants identifying three interrelated properties as being potentially morally injurious: chronic societal problems, impaired systems, and organizational quagmires. Participants navigated their moral frustrations through both integrative and disintegrative pathways, resulting in either needing to escape their moral suffering or transforming ontologically. The current study results support MI as a relevant concept for frontline PSP. Given the seriousness of PSP leaving their profession or committing suicide to escape moral suffering, the importance of the impact of MI on PSP and public safety organizations cannot be ignored or underestimated. Understanding the similarities and differences of morally injurious exposures of frontline PSP may be critical for determining mental health and resilience strategies that effectively protect PSP.
Reconstruction of a Neglected, Extensor Hallucis Longus Tendon Rupture Using Interposed Scar Tissue: A Case Report and Literature Review
Authors: Kim Woo-Jong , Jung Ki-Jin , Ahn Hyein , Yeo Eui-Dong , Lee Hong-Seop , Won Sung-Hun , Lee Dhong-Won , Ji Jae-Young , Yoon Sung-Joon , Hong Yong-Cheol
Published: November 2021

Injury of the extensor hallucis longus (EHL) tendon is relatively rare, but surgical repair is necessary to prevent deformity and gait disturbance. Primary suturing is possible if the condition is acute, but not when it is chronic. The scar tissue between the ruptured ends is a proliferative tissue composed of fibroblasts and collagen fibers. Given the histological similarity to normal tendons, several studies have reported tendon reconstruction using scar tissue. Here, we report a reconstruction of a neglected EHL rupture using interposed scar tissue. A 54-year-old female visited our clinic with a weak extension of a big toe. She had dropped a knife on her foot a month prior, but did not go to hospital. The wound had healed, but she noted dysfunctional extension of the toe and increasing pain. Magnetic resonance imaging (MRI) revealed that EHL continuity was lost and that the proximal tendon stump was displaced toward the midfoot. Scar tissue running in the direction of the original ligament was observed between the ruptured ends. In the surgical field, the scar tissue formed a shape similar to the extensor tendon. Therefore, we performed tendon reconstruction using the interposed scar tissue. For the first 2 postoperative weeks, the ankle and foot were immobilized to protect the repair. Six weeks after surgery, the patient commenced full weight-bearing. At the 3-month follow-up, active extension of the hallux was possible, with a full range of motion. The patient did not feel any discomfort during daily life. Postoperative MRI performed at 1 year revealed that the reconstructed EHL exhibited homogeneously low signal intensity, and was continuous. The AOFAS Hallux Metatarsophalangeal-Interphalangeal scale improved from 57 to 90 points and the FAAM scores improved from 74% to 95% (the Activities of Daily Living subscale) and from 64% to 94% (the Sports subscale). Scar tissue reconstruction is as effective as tendon autografting or allografting, eliminates the risk of donor site morbidity and infection, and requires only a small incision and a short operative time.
A Long-Term Follow-Up of Dental and Craniofacial Disturbances after Cancer Therapy in a Pediatric Rhabdomyosarcoma Patient: Case Report
Authors: Chang Pei-Ching , Lin Shiao-Yu
Published: November 2021

Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children and adolescents. A boy aged seven years and five months was diagnosed with stage three group III embryonal parameningeal RMS with intracranial extension. He received chemotherapy for 23 weeks in combination with localized radiotherapy during the inductive phase of nine weeks (a total tumor dose of 5040 cGy). Three months later, he was referred to the department of pediatric dentistry for radiation-induced caries, the treatment of which was later terminated because of severe trismus and radiation-induced oropharyngeal mucositis. Three years later, the patient returned for the fitting of a prosthesis because of mastication problems. The dental treatments performed included: extraction, banding, composite resin restorations, root canal fillings, and stainless steel crown fabrication. An interim denture was fitted due to the poor retention of the fixed prosthesis. As the patient grew older, they developed facial asymmetry as a result of the prominent atrophy of their right cheek. By the age of 32, they had lost multiple teeth and exhibited severe facial deformity. Therefore, it is essential not only to involve a multidisciplinary medical team before, during, and after cancer therapy, but also to initiate long-term follow-ups given the potential effects of late sequelae after chemoradiation in multiple developmental areas.
Spatial Clustering of County-Level COVID-19 Rates in the U.S.
Authors: Andrews Marcus R. , Tamura Kosuke , Best Janae N. , Ceasar Joniqua N. , Batey Kaylin G. , Kearse Troy A. , Allen Lavell V. , Baumer Yvonne , Collins Billy S. , Mitchell Valerie M. , Powell-Wiley Tiffany M.
Published: November 2021

Despite the widespread prevalence of cases associated with the coronavirus disease 2019 (COVID-19) pandemic, little is known about the spatial clustering of COVID-19 in the United States. Data on COVID-19 cases were used to identify U.S. counties that have both high and low COVID-19 incident proportions and clusters. Our results suggest that there are a variety of sociodemographic variables that are associated with the severity of COVID-19 county-level incident proportions. As the pandemic evolved, communities of color were disproportionately impacted. Subsequently, it shifted from communities of color and metropolitan areas to rural areas in the U.S. Our final period showed limited differences in county characteristics, suggesting that COVID-19 infections were more widespread. The findings might address the systemic barriers and health disparities that may result in high incident proportions of COVID-19 clusters.
Impact of Telehealth Care among Adults Living with Type 2 Diabetes in Primary Care: A Systematic Review and Meta-Analysis of Randomised Controlled Trials
Authors: Robson Natalie , Hosseinzadeh Hassan
Published: November 2021

Primary health care physicians are increasingly offering telehealth services to patients not only for its cost and time saving advantages but for the additional benefits telehealth can provide for patients with type 2 diabetes (T2D) such as improved self-management behaviours. To support the development of telehealth based T2D clinical care models in primary health care settings, a narrative synthesis and meta-analysis of randomised controlled trial studies was completed for 29 studies that evaluated the effect of one or more types of telehealth interventions on HbA1c levels compared to usual care alone. Results from the random effects meta-analysis demonstrated that telehealth interventions had a stronger influence on HbA1c compared to usual care with a mean difference in HbA1c \% −0.18 (CI −0.35, −0.01), p = 0.04. Results from the subgroup meta-analysis demonstrated that telehealth interventions, when grouped by type of telemonitoring (mHealth and telephone communication), all have a stronger effect on lowering HbA1c levels; however, none of these findings were significant. Key findings from this review demonstrate that telehealth interventions that address T2D self-management behaviours and have higher levels of health care provider engagement, have greater effects on lowering HbA1c levels compared to usual care alone.
The Evolvement of Rail Transit Network Structure and Impact on Travel Characteristics: A Case Study of Wuhan
Authors: Peng Jiandong , Cui Changwei , Qi Jiajie , Ruan Zehan , Dai Qi , Yang Hong
Published: November 2021

The expansion of the rail transit network has a positive impact on travel characteristics under spatial and temporal constraints by changing accessibility. However, few empirical studies have examined the longitudinal evolution of the impact of accessibility and travel characteristics. In this paper, a model of the Wuhan rail transit network is constructed and the evolution of the spatial pattern of accessibility over different periods is analyzed. The correlation of accessibility with rail transit travel characteristics is studied longitudinally to provide theoretical support for rail transit construction and traffic demand management. The study shows that: (1) Wuhan’s rail transit network has evolved from a tree to a ring, improving the operational efficiency. (2) The accessibility of Wuhan’s rail transit network has evolved into a circular structure, showing a decreasing trend away from the city center. (3) The change of accessibility greatly affects travel characteristics. The higher the accessibility, the higher the traffic volume, and the lower the travel frequency, the more residents travel during peak hours, and the shorter the travel distance. These findings are useful for gaining insight into public transportation demand in large cities, and thus for developing reasonable transportation demand management policies.