bluuebunny/crossref_metadata_2025 huggingface dataset:
Supplementary Tables S3-S4 from Epigenetic Regulator Smchd1 Functions as a Tumor Suppressor
Authors: Leong Huei San , Chen Kelan , Hu Yifang , Lee Stanley , Corbin Jason , Pakusch Miha , Murphy James M. , Majewski Ian J. , Smyth Gordon K. , Alexander Warren S. , Hilton Douglas J. , Blewitt Marnie E.
Published: April 2023

Supplementary Tables S3-S4 XLSX file - 576K, Gene set analysis (Camera) and differentially expressed genes
Supplementary Figures from Substance P Autocrine Signaling Contributes to Persistent HER2 Activation That Drives Malignant Progression and Drug Resistance in Breast Cancer
Authors: Garcia-Recio Susana , Fuster Gemma , Fernandez-Nogueira Patricia , Pastor-Arroyo Eva M. , Park So Yeon , Mayordomo Cristina , Ametller Elisabet , Mancino Mario , Gonzalez-Farre Xavier , Russnes Hege G. , Engel Pablo , Costamagna Domiziana , Fernandez Pedro L. , Gascón Pedro , Almendro Vanessa
Published: April 2023

PDF file, 12332K, Supplementary Figure S1. Expression of NK-1R, NK-2R and SP in normal mammary epithelium. Supplementary Figure S2. Transactivation of HER2 by human tachykinins. Supplementary Figure S3. Dose-response effect of SP on HER2 activation. Supplementary Figure S4. Contribution of HER2 signaling to SP-induced MAPK activation. Supplementary Figure S5. Representative images of NK-1R immunohistochemistry in the tumors used for primary cultures. Supplementary Figure S6. Activation of HER2 under SP treatment in each primary culture derived from 19 primary breast tumors. Supplementary Figure S7. Overexpression of NK-1R in BC cells. Supplementary Figure S8. Mitotic index for the MDA-MB-231 and MDA-MB-453 xenograft tumors growth under the continuous exposure to SP. Supplementary Figure S9. Immunohistochemical analysis of the xenograft tumors treated with the NK-1R inhibitor L-733,060. Supplementary Figure S10. Acute and chronic effects of SP on cellular responses to anti-HER2 and anti-EGFR therapies. Supplementary Table S1. Statistical analysis for the correlation of NK-1R, NK-2R and SP expression levels. Supplementary Table S2. Statistical analysis for the correlation of NK-1R, NK-2R and SP expression levels. Supplementary Table S3. Clinical information of the cohort used to investigate the levels of circulating SP in healthy donors and breast cancer patients. Supplementary Table S4. Histopathologic information of the samples used Supplementary Table S5. IC50 obtained in the drug-response studies and combination index.
Supplementary Methods from Complex Tumor Genomes Inferred from Single Circulating Tumor Cells by Array-CGH and Next-Generation Sequencing
Authors: Heitzer Ellen , Auer Martina , Gasch Christin , Pichler Martin , Ulz Peter , Hoffmann Eva Maria , Lax Sigurd , Waldispuehl-Geigl Julie , Mauermann Oliver , Lackner Carolin , Höfler Gerald , Eisner Florian , Sill Heinz , Samonigg Hellmut , Pantel Klaus , Riethdorf Sabine , Bauernhofer Thomas , Geigl Jochen B. , Speicher Michael R.
Published: April 2023

PDF file - 146K, Additional clinical data and detailed Material & Methods section
Supplementary Figure 7 from Complex Tumor Genomes Inferred from Single Circulating Tumor Cells by Array-CGH and Next-Generation Sequencing
Authors: Heitzer Ellen , Auer Martina , Gasch Christin , Pichler Martin , Ulz Peter , Hoffmann Eva Maria , Lax Sigurd , Waldispuehl-Geigl Julie , Mauermann Oliver , Lackner Carolin , Höfler Gerald , Eisner Florian , Sill Heinz , Samonigg Hellmut , Pantel Klaus , Riethdorf Sabine , Bauernhofer Thomas , Geigl Jochen B. , Speicher Michael R.
Published: April 2023

PDF file - 868K, Ratio bin distributions for CTC12 (a) and CTC03 (b) from patient #6. The large bin 13 peak indicates the frequency of oligonucleotides with balanced ratio values. The bins to the right of 13 represent the bins for oligonucleotides with deleted, the bins to the left oligonucleotides with increased values. (a) In CTC12 only one of the bins for deleted values was increased (i.e. bin 15), suggesting that this cell is diploid. In a diploid cell the log2 ratio for balanced values ranges from 0.295 to -0.293 and therefore extends to bins adjacent to 13, which is reflected by the small increases in the bins 12 and 14. The peaks at bins 11 and 12 reflect trisomies (i.e. a 3:2 ratio or an integer copy number of 3), the peak at 9 indicates tetrasomies (i.e. 4:2) or 4 copies). (b) CTC03 had clearly more discrete deleted copy number states visible at bins 15 to 18, suggesting that this cell is tetraploid. In a tetraploid cell the log2 ratio range for balanced values is narrower (i.e. 0.161 to -0.208) as in a diploid cell, which is reflected in the almost empty bins 12 and 14. Bin 15 represents oligonucleotides with ratio values translating to 3 copies, bins 16 and 17 to two copies and bin 18 to one copy. Bin 10 represents 5 copies, bins 8 and 9 six copies, bin 7 seven copies, and bin 4 eight copies.
Supplementary Figure 6 from Complex Tumor Genomes Inferred from Single Circulating Tumor Cells by Array-CGH and Next-Generation Sequencing
Authors: Heitzer Ellen , Auer Martina , Gasch Christin , Pichler Martin , Ulz Peter , Hoffmann Eva Maria , Lax Sigurd , Waldispuehl-Geigl Julie , Mauermann Oliver , Lackner Carolin , Höfler Gerald , Eisner Florian , Sill Heinz , Samonigg Hellmut , Pantel Klaus , Riethdorf Sabine , Bauernhofer Thomas , Geigl Jochen B. , Speicher Michael R.
Published: April 2023

PDF file - 188K, Sequencing of UCR41 and flanking regions: UCR41 is a 217-bp-long ultra-conserved region depicted in dark green. The gray bar indicates the extremely conserved sequence. The region is flanked by two SNPs that are frequent in the European population (blue arrows). The black curve indicates the mutability, which is higher in non-conserved regions compared with conserved segments. The black bars illustrate the 5 overlapping amplicons used for amplification. Mutations identified in our samples are indicated with red arrows. The genomic coordinates refer to the hg18 assembly of the human genome. (The graph is reproduced with permission from De Grassi et al.)
Supplementary Figure 2C from Complex Tumor Genomes Inferred from Single Circulating Tumor Cells by Array-CGH and Next-Generation Sequencing
Authors: Heitzer Ellen , Auer Martina , Gasch Christin , Pichler Martin , Ulz Peter , Hoffmann Eva Maria , Lax Sigurd , Waldispuehl-Geigl Julie , Mauermann Oliver , Lackner Carolin , Höfler Gerald , Eisner Florian , Sill Heinz , Samonigg Hellmut , Pantel Klaus , Riethdorf Sabine , Bauernhofer Thomas , Geigl Jochen B. , Speicher Michael R.
Published: April 2023

PDF file - 231K, Evaluation of available material from patient #6. (c) Integer copy number profiles of CTC14.
Supplementary Figure 2 from Complex Tumor Genomes Inferred from Single Circulating Tumor Cells by Array-CGH and Next-Generation Sequencing
Authors: Heitzer Ellen , Auer Martina , Gasch Christin , Pichler Martin , Ulz Peter , Hoffmann Eva Maria , Lax Sigurd , Waldispuehl-Geigl Julie , Mauermann Oliver , Lackner Carolin , Höfler Gerald , Eisner Florian , Sill Heinz , Samonigg Hellmut , Pantel Klaus , Riethdorf Sabine , Bauernhofer Thomas , Geigl Jochen B. , Speicher Michael R.
Published: April 2023

PDF file - 940K, Evaluation of available material from patient #6. (a-b) Array CGH profiles of the primary tumor (a) and metastasis (b). The multicolor bar codes at the top or bottom of the ratio profiles illustrate the results obtained during the iterative calculations with various window sizes, the single green and red bars summarize the regions which were gained or lost based on all calculations (Supplementary Methods). Black parts in the profile represent balanced regions, lost regions appear in red and gained regions in green.
Supplementary Table S1 from Chromothripsis and Focal Copy Number Alterations Determine Poor Outcome in Malignant Melanoma
Authors: Hirsch Daniela , Kemmerling Ralf , Davis Sean , Camps Jordi , Meltzer Paul S. , Ried Thomas , Gaiser Timo
Published: April 2023

Supplementary Table S1 PDF file 43K,Summary of aCGH gains and losses in the 18 MM samples
Supplementary Figure Legends from Differential Contributions of STAT5A and STAT5B to Stress Protection and Tyrosine Kinase Inhibitor Resistance of Chronic Myeloid Leukemia Stem/Progenitor Cells
Authors: Casetti Luana , Martin-Lannerée Séverine , Najjar Imen , Plo Isabelle , Augé Sylvie , Roy Lydia , Chomel Jean-Claude , Lauret Evelyne , Turhan Ali G. , Dusanter-Fourt Isabelle
Published: April 2023

PDF file - 32K
Supplementary Video 7 from Senescent Fibroblasts in Melanoma Initiation and Progression: An Integrated Theoretical, Experimental, and Clinical Approach
Authors: Kim Eunjung , Rebecca Vito , Fedorenko Inna V. , Messina Jane L. , Mathew Rahel , Maria-Engler Silvya S. , Basanta David , Smalley Keiran S.M. , Anderson Alexander R.A.
Published: April 2023

MOV file - 8219K, This video shows the spatio-temporal evolution of vSkin that produced Figure 6b (minimally transformed melanocytes and highly senescent fibroblasts).
Supplementary Figure S7 from mTOR Complex 2 Is Involved in Regulation of Cbl-Dependent c-FLIP Degradation and Sensitivity of TRAIL-Induced Apoptosis
Authors: Zhao Liqun , Yue Ping , Khuri Fadlo R. , Sun Shi-Yong
Published: April 2023

Supplementary Figure S7 PDF file - 106K, Enforced activation of Akt does not impair the ability of PP242 to reduce FLIPS levels
Supplementary Video 3 from Senescent Fibroblasts in Melanoma Initiation and Progression: An Integrated Theoretical, Experimental, and Clinical Approach
Authors: Kim Eunjung , Rebecca Vito , Fedorenko Inna V. , Messina Jane L. , Mathew Rahel , Maria-Engler Silvya S. , Basanta David , Smalley Keiran S.M. , Anderson Alexander R.A.
Published: April 2023

MOV file - 9113K, This video shows the spatio-temporal evolution of vSkin that produced Figure 4B (biochemical perturbation).
Supplementary Figure S4 from mTOR Complex 2 Is Involved in Regulation of Cbl-Dependent c-FLIP Degradation and Sensitivity of TRAIL-Induced Apoptosis
Authors: Zhao Liqun , Yue Ping , Khuri Fadlo R. , Sun Shi-Yong
Published: April 2023

Supplementary Figure S4 PDF file - 256K, Both INK128 (A and C) and BEZ235 (B and D) decrease FLIPS levels (A and B) and synergy with TRAIL to kill cancer cells (C and D)
Supplementary Figure S3 from mTOR Complex 2 Is Involved in Regulation of Cbl-Dependent c-FLIP Degradation and Sensitivity of TRAIL-Induced Apoptosis
Authors: Zhao Liqun , Yue Ping , Khuri Fadlo R. , Sun Shi-Yong
Published: April 2023

Supplementary Figure S3 PDF file - 99K, Impact of stable knockdown of rictor or raptor on the expression of c-FLIP and survivin in A549 cells
Supplementary Figure 3 from Transient Antiangiogenic Treatment Improves Delivery of Cytotoxic Compounds and Therapeutic Outcome in Lung Cancer
Authors: Chatterjee Sampurna , Wieczorek Caroline , Schöttle Jakob , Siobal Maike , Hinze Yvonne , Franz Thomas , Florin Alexandra , Adamczak Joanna , Heukamp Lukas C. , Neumaier Bernd , Ullrich Roland T.
Published: April 2023

PDF file - 665KB, Imaging of tumor cell proliferation using 18FFLT PET in H1975 tumors.
Supplementary Figure 2 from Transient Antiangiogenic Treatment Improves Delivery of Cytotoxic Compounds and Therapeutic Outcome in Lung Cancer
Authors: Chatterjee Sampurna , Wieczorek Caroline , Schöttle Jakob , Siobal Maike , Hinze Yvonne , Franz Thomas , Florin Alexandra , Adamczak Joanna , Heukamp Lukas C. , Neumaier Bernd , Ullrich Roland T.
Published: April 2023

PDF file - 677KB, Multimodal imaging of tumor blood flow using 15OH2O PET in xenograft (H1975) in mice using ZD6474 as anti-angiogenic agent.
Supplementary Video 7 from Endogenous Two-Photon Fluorescence Imaging Elucidates Metabolic Changes Related to Enhanced Glycolysis and Glutamine Consumption in Precancerous Epithelial Tissues
Authors: Varone Antonio , Xylas Joanna , Quinn Kyle P. , Pouli Dimitra , Sridharan Gautham , McLaughlin-Drubin Margaret E. , Alonzo Carlo , Lee Kyongbum , Münger Karl , Georgakoudi Irene
Published: April 2023

AVI file - 1119KB, Representative endogenous TPEF OPTICAL STACK E6E7 EETE.
Supplementary Video 4 from Endogenous Two-Photon Fluorescence Imaging Elucidates Metabolic Changes Related to Enhanced Glycolysis and Glutamine Consumption in Precancerous Epithelial Tissues
Authors: Varone Antonio , Xylas Joanna , Quinn Kyle P. , Pouli Dimitra , Sridharan Gautham , McLaughlin-Drubin Margaret E. , Alonzo Carlo , Lee Kyongbum , Münger Karl , Georgakoudi Irene
Published: April 2023

AVI file - 1230KB, Representative 3D RENDERING HKcDR EETE.
Supplementary Video 3 from Endogenous Two-Photon Fluorescence Imaging Elucidates Metabolic Changes Related to Enhanced Glycolysis and Glutamine Consumption in Precancerous Epithelial Tissues
Authors: Varone Antonio , Xylas Joanna , Quinn Kyle P. , Pouli Dimitra , Sridharan Gautham , McLaughlin-Drubin Margaret E. , Alonzo Carlo , Lee Kyongbum , Münger Karl , Georgakoudi Irene
Published: April 2023

AVI file - 970KB, Representative endogenous TPEF OPTICAL STACK HKcDR EETE.
Supplementary Figure 3 from Endogenous Two-Photon Fluorescence Imaging Elucidates Metabolic Changes Related to Enhanced Glycolysis and Glutamine Consumption in Precancerous Epithelial Tissues
Authors: Varone Antonio , Xylas Joanna , Quinn Kyle P. , Pouli Dimitra , Sridharan Gautham , McLaughlin-Drubin Margaret E. , Alonzo Carlo , Lee Kyongbum , Münger Karl , Georgakoudi Irene
Published: April 2023

PDF file - 107KB, Quantitative evaluation of PCNA staining (green) with respect to DAPI staining (blue) throughout the depth of the EETEs.
Supplementary Figure 3 from Mixed Lineage Kinase MLK4 Is Activated in Colorectal Cancers Where It Synergistically Cooperates with Activated RAS Signaling in Driving Tumorigenesis
Authors: Martini Miriam , Russo Mariangela , Lamba Simona , Vitiello Elisa , Crowley Emily Hannah , Sassi Francesco , Romanelli Davide , Frattini Milo , Marchetti Antonio , Bardelli Alberto
Published: April 2023

PDF file - 422K, A) Ctrl and MLK4 knock down (Sh1 and Sh2) Sw48 cells were stimulated with EGF (2nM-20 nM) at 37 {degree sign}C for 10 minutes. Cell lysates were subjected to western blotting with the indicated antibodies. B) Parental and MLK4 -/- HCT116 cells were stimulated with EGF (2nM-20 nM) at 37 {degree sign}C for 10 minutes. Cell lysates were subjected to western blotting with the indicated antibodies.
Supplementary Figure 2 from Mixed Lineage Kinase MLK4 Is Activated in Colorectal Cancers Where It Synergistically Cooperates with Activated RAS Signaling in Driving Tumorigenesis
Authors: Martini Miriam , Russo Mariangela , Lamba Simona , Vitiello Elisa , Crowley Emily Hannah , Sassi Francesco , Romanelli Davide , Frattini Milo , Marchetti Antonio , Bardelli Alberto
Published: April 2023

PDF file - 246K, A) Proliferation rates of HCT116 parental and MLK4 -/- cancer cells (two independent clones).*p value < 0.05; **p value < 0.01; error bars represent s.d; FC, fold change. B) Expression levels of the MLK4 protein were assessed by western blotting in control (ctrl) and MLK4 knock down LoVo cells (upper panel). C) Proliferation rates of ctrl and MLK4 knock down LoVo cells grown in plastic . *p value < 0.05; **p value < 0.01; error bars represent s.d; FC, fold change. D) Proliferation rates of Ctrl and MLK4 knock down LoVo cells grown in low adherence conditions. *p value < 0.05; **p value < 0.01; error bars represent s.d; FC, fold change. E) Anchorage-independent growth (soft agar) assay performed on control and MLK4 knock down LoVo cells. ***p value < 0.001; error bars represent s.d.
Supplementary Table 1 from TGF-β Mediates Homing of Bone Marrow–Derived Human Mesenchymal Stem Cells to Glioma Stem Cells
Authors: Shinojima Naoki , Hossain Anwar , Takezaki Tatsuya , Fueyo Juan , Gumin Joy , Gao Feng , Nwajei Felix , Marini Frank C. , Andreeff Michael , Kuratsu Jun-Ichi , Lang Frederick F.
Published: April 2023

PDF file - 57K, Primer sequences for STR markers.
Supplementary Table 1 from Natural Human Plasmacytoid Dendritic Cells Induce Antigen-Specific T-Cell Responses in Melanoma Patients
Authors: Tel Jurjen , Aarntzen Erik H.J.G. , Baba Tetsuro , Schreibelt Gerty , Schulte Barbara M. , Benitez-Ribas Daniel , Boerman Otto C. , Croockewit Sandra , Oyen Wim J.G. , van Rossum Michelle , Winkels Gregor , Coulie Pierre G. , Punt Cornelis J.A. , Figdor Carl G. , de Vries I. Jolanda M.
Published: April 2023

Supplementary Table 1 PDF file - 29K, Induration (mm) of the different injection sites in the DTH skin test
Supplementary Figure Legend from TGF-β Mediates Homing of Bone Marrow–Derived Human Mesenchymal Stem Cells to Glioma Stem Cells
Authors: Shinojima Naoki , Hossain Anwar , Takezaki Tatsuya , Fueyo Juan , Gumin Joy , Gao Feng , Nwajei Felix , Marini Frank C. , Andreeff Michael , Kuratsu Jun-Ichi , Lang Frederick F.
Published: April 2023

PDF file - 64K
Supplementary Figure 3 from TGF-β Mediates Homing of Bone Marrow–Derived Human Mesenchymal Stem Cells to Glioma Stem Cells
Authors: Shinojima Naoki , Hossain Anwar , Takezaki Tatsuya , Fueyo Juan , Gumin Joy , Gao Feng , Nwajei Felix , Marini Frank C. , Andreeff Michael , Kuratsu Jun-Ichi , Lang Frederick F.
Published: April 2023

PDF file - 29856K, Assays of STR polymorphism using twelve unique markers in RCS, RAT2, C6, GSC001 low, GSC001 high cells.
Supplementary Figure 2 from FOXC2 Expression Links Epithelial–Mesenchymal Transition and Stem Cell Properties in Breast Cancer
Authors: Hollier Brett G. , Tinnirello Agata A. , Werden Steven J. , Evans Kurt W. , Taube Joseph H. , Sarkar Tapasree Roy , Sphyris Nathalie , Shariati Maryam , Kumar Sreedevi V. , Battula Venkata L. , Herschkowitz Jason I. , Guerra Rudy , Chang Jeffrey T. , Miura Naoyuki , Rosen Jeffrey M. , Mani Sendurai A.
Published: April 2023

Supplementary Figure 2 PDF File - 600K, Ectopic expression of FOXC2 induces EMT in transformed human mammary epithelial cells (HMLER). (a) Quantification of EMT marker mRNA expression by quantitative real-time PCR analysis. Data is represented as the expression of EMT markers in HMLER-FOXC2 (FOXC2) cells relative to HMLER-Vector control cells (Vector). GAPDH was used as an internal normalization control. Columns indicate the mean (n = 3); error bars indicate SEM. (b) Western blot analysis of EMT marker protein expression upon FOXC2 overexpression in HMLER cells. Actin was used as a loading control. (c) Phase contrast and immunofluroescence images of HMLER-Vector and HMLER-FOXC2 cells. Overlayed images are shown for respective EMT markers (red) and DAPI nuclear stain (blue). Scale bar indicates 50 �m
Supplementary Figure 1 from TGF-β Mediates Homing of Bone Marrow–Derived Human Mesenchymal Stem Cells to Glioma Stem Cells
Authors: Shinojima Naoki , Hossain Anwar , Takezaki Tatsuya , Fueyo Juan , Gumin Joy , Gao Feng , Nwajei Felix , Marini Frank C. , Andreeff Michael , Kuratsu Jun-Ichi , Lang Frederick F.
Published: April 2023

PDF file - 1222K, The migration of BM-hMSCs toward increasing concentrations of TGF-β1.
Supplementary Figure 5 from Myeloid-Specific Expression of Ron Receptor Kinase Promotes Prostate Tumor Growth
Authors: Gurusamy Devikala , Gray Jerilyn K. , Pathrose Peterson , Kulkarni Rishikesh M. , Finkleman Fred D. , Waltz Susan E.
Published: April 2023

PDF file - 50K, Microvessel staining in tumors isolated from TKf/f and TKf/f LysMcre+ mice. For Review and Publication Both.
Supplementary Table S1 from MYC Regulation of CHK1 and CHK2 Promotes Radioresistance in a Stem Cell-like Population of Nasopharyngeal Carcinoma Cells
Authors: Wang Wen-Jun , Wu Si-Pei , Liu Jia-Bin , Shi Yong-Sheng , Huang Xue , Zhang Qian-Bing , Yao Kai-Tai
Published: April 2023

XLS file - 34K,All primers used for the constructs and PCR
Supplementary Methods from MYC Regulation of CHK1 and CHK2 Promotes Radioresistance in a Stem Cell-like Population of Nasopharyngeal Carcinoma Cells
Authors: Wang Wen-Jun , Wu Si-Pei , Liu Jia-Bin , Shi Yong-Sheng , Huang Xue , Zhang Qian-Bing , Yao Kai-Tai
Published: April 2023

PDF file - 174K,Include: Clonogenic survival assay;Patients and primary NPC samples;Ethics Statement;Quantitative real-time (qRT)-PCR;Alkaline comet assay ;Plasmids, oligonucleotides, and transfections;Luciferase assay;EdU labeling;c-MycBS prediction and ChIP assay;Immunohistochemistry
Supplementary Legends from MYC Regulation of CHK1 and CHK2 Promotes Radioresistance in a Stem Cell-like Population of Nasopharyngeal Carcinoma Cells
Authors: Wang Wen-Jun , Wu Si-Pei , Liu Jia-Bin , Shi Yong-Sheng , Huang Xue , Zhang Qian-Bing , Yao Kai-Tai
Published: April 2023

PDF file - 68K, Supplemental Figure Legends
Supplementary Figure 3 from MYC Regulation of CHK1 and CHK2 Promotes Radioresistance in a Stem Cell-like Population of Nasopharyngeal Carcinoma Cells
Authors: Wang Wen-Jun , Wu Si-Pei , Liu Jia-Bin , Shi Yong-Sheng , Huang Xue , Zhang Qian-Bing , Yao Kai-Tai
Published: April 2023

PDF file - 1299K,A, Western blot detection of CHK1 and CHK2 in CNE2 cells. B, Western blot detection of c-MYC, CHK1 and CHK2 in PKH26+ NPC cells after treated with c-Myc shRNA
Supplementary Figure 2 from MYC Regulation of CHK1 and CHK2 Promotes Radioresistance in a Stem Cell-like Population of Nasopharyngeal Carcinoma Cells
Authors: Wang Wen-Jun , Wu Si-Pei , Liu Jia-Bin , Shi Yong-Sheng , Huang Xue , Zhang Qian-Bing , Yao Kai-Tai
Published: April 2023

PDF file - 2674K, A, Western blot analysis of c-MYC, CHK1, and CHK2 in vector control and c-MYC+shCHK1/shCHK2 infected PKH26- NPC CNE2 cells. B. EdU proliferation assay of vector control, c-MYC, and c-MYC+shCHK1/CHK2 infected irradiated (8 Gy) PKH26- NPC CNE2 cells. Quantification of the percentages of cells with comet tails following irradiation at different doses. (Data represent the mean�standard deviation (SD); N = 3; *P=0.000; **P=0.064, with a 20 msec exposure time for image acquisition). C. Alkaline comet assay of vector control, c-MYC, and c-MYC+shCHK1/CHK2 infected irradiated (8 Gy) PKH26+NPC CNE2 cells. Quantification of the percentages of cells with comet tails following irradiation at different doses (Data represent the mean�standard deviation (SD); N = 3; *P=0.000; **P=0.102)
Supplementary Figure 2 from mTOR Inhibitors Block Kaposi Sarcoma Growth by Inhibiting Essential Autocrine Growth Factors and Tumor Angiogenesis
Authors: Roy Debasmita , Sin Sang-Hoon , Lucas Amy , Venkataramanan Raman , Wang Ling , Eason Anthony , Chavakula Veenadhari , Hilton Isaac B. , Tamburro Kristen M. , Damania Blossom , Dittmer Dirk P.
Published: April 2023

PDF file - 84K, Suppl. Figure 2: Apoptosis induction of PEL cells by combination of rapamycin and doxorubicin in culture
Supplementary Figure 1 from MYC Regulation of CHK1 and CHK2 Promotes Radioresistance in a Stem Cell-like Population of Nasopharyngeal Carcinoma Cells
Authors: Wang Wen-Jun , Wu Si-Pei , Liu Jia-Bin , Shi Yong-Sheng , Huang Xue , Zhang Qian-Bing , Yao Kai-Tai
Published: April 2023

PDF file - 2945K, A, Flow cytometry of CD44 expression in PHK26 + cells. Data represent the mean�standard deviation (SD); n = 3. B, The delineation of CNE1 and CNE2 cells after labeling with PKH26 and treated with PI in Flow cytometry. C, RT-PCR validation of c-MYC, CHK1, CHK2, and ATM RNA levels in CNE2 cells. D, Western blot analysis of c-MYC, pCHK1, and pCHK2 markers in CNE2 cells. GAPDH served as a loading control
Supplementary Figure 1 from mTOR Inhibitors Block Kaposi Sarcoma Growth by Inhibiting Essential Autocrine Growth Factors and Tumor Angiogenesis
Authors: Roy Debasmita , Sin Sang-Hoon , Lucas Amy , Venkataramanan Raman , Wang Ling , Eason Anthony , Chavakula Veenadhari , Hilton Isaac B. , Tamburro Kristen M. , Damania Blossom , Dittmer Dirk P.
Published: April 2023

PDF file - 41K, Suppl. Figure 1: Inhibition of VEGF secretion of PEL cells by rapamycin as measured by ELISA and bioassay.
Supplementary Table 1 from Characterization of Torin2, an ATP-Competitive Inhibitor of mTOR, ATM, and ATR
Authors: Liu Qingsong , Xu Chunxiao , Kirubakaran Sivapriya , Zhang Xin , Hur Wooyoung , Liu Yan , Kwiatkowski Nicholas P. , Wang Jinhua , Westover Kenneth D. , Gao Peng , Ercan Dalia , Niepel Mario , Thoreen Carson C. , Kang Seong A. , Patricelli Matthew P. , Wang Yuchuan , Tupper Tanya , Altabef Abigail , Kawamura Hidemasa , Held Kathryn D. , Chou Danny M. , Elledge Stephen J. , Janne Pasi A. , Wong Kwok-Kin , Sabatini David M. , Gray Nathanael S.
Published: April 2023

PDF file - 401K
Supplementary Figures 1 - 4 from Characterization of Torin2, an ATP-Competitive Inhibitor of mTOR, ATM, and ATR
Authors: Liu Qingsong , Xu Chunxiao , Kirubakaran Sivapriya , Zhang Xin , Hur Wooyoung , Liu Yan , Kwiatkowski Nicholas P. , Wang Jinhua , Westover Kenneth D. , Gao Peng , Ercan Dalia , Niepel Mario , Thoreen Carson C. , Kang Seong A. , Patricelli Matthew P. , Wang Yuchuan , Tupper Tanya , Altabef Abigail , Kawamura Hidemasa , Held Kathryn D. , Chou Danny M. , Elledge Stephen J. , Janne Pasi A. , Wong Kwok-Kin , Sabatini David M. , Gray Nathanael S.
Published: April 2023

PDF file - 719K, Supplemental figure 1. Torin2 on PC-3 wide type cell line, the IB was made after 30 min treatment of drug at indicated concentrations. Supplemental figure 2. Torin1, Torin2, AZD8055 and BEZ235 on HeLa and HCT-116 cell line at different time point with a dose responsive drug treatment. Supplemental figure 3. PET-CT experiment of short term treatment of drugs. Supplemental figure 4. PDG-PET determination of drug treatment response with statistics
Supplementary Figure 5 from PTEN Loss Mitigates the Response of Medulloblastoma to Hedgehog Pathway Inhibition
Authors: Metcalfe Ciara , Alicke Bruno , Crow Ailey , Lamoureux Marlea , Dijkgraaf Gerrit J.P. , Peale Franklin , Gould Stephen E. , de Sauvage Frederic J.
Published: April 2023

PDF file - 77K, GNE-317, but not vismodegib, reduces the levels of pAKT in the PPM model. Western blot analysis of lysates from allografts, treated as indicated.
Supplementary Figure 4 from PTEN Loss Mitigates the Response of Medulloblastoma to Hedgehog Pathway Inhibition
Authors: Metcalfe Ciara , Alicke Bruno , Crow Ailey , Lamoureux Marlea , Dijkgraaf Gerrit J.P. , Peale Franklin , Gould Stephen E. , de Sauvage Frederic J.
Published: April 2023

PDF file - 5347K, Illustration of CC3 IHC image analysis. Bright-field images of CC3 IHC were imported into ImageJ. Automated local thresholding (Niblack method) and watershed segmentation were used to identify all nuclei, and total nuclear area was calculated. Dark CC3 positive areas were subsequently identified using a predetermined intensity-based threshold, and the area representative of these regions was calculated, enabling us to calculate % CC3 positive area as a function of total nuclear area.
Supplementary Figure 3 from PTEN Loss Mitigates the Response of Medulloblastoma to Hedgehog Pathway Inhibition
Authors: Metcalfe Ciara , Alicke Bruno , Crow Ailey , Lamoureux Marlea , Dijkgraaf Gerrit J.P. , Peale Franklin , Gould Stephen E. , de Sauvage Frederic J.
Published: April 2023

PDF file - 286K,Proliferation is suppressed in PPM tumors. Phosphorylation of histone H3 (pH3) is tightly correlated with chromosome condensation during mitosis. PM tumors have a high frequency of pH3 positive cells, while in PPM and PPwt/loxpM tumors, pH3 positive cells tend to occur in restricted regions.
Supplementary Figure 2 from PTEN Loss Mitigates the Response of Medulloblastoma to Hedgehog Pathway Inhibition
Authors: Metcalfe Ciara , Alicke Bruno , Crow Ailey , Lamoureux Marlea , Dijkgraaf Gerrit J.P. , Peale Franklin , Gould Stephen E. , de Sauvage Frederic J.
Published: April 2023

PDF file - 1233K, Loss of PTEN in Math1-expressing granule neuronal precursor cells results in ectopic positioning of enlarged NeuN-expressing cells.
Supplementary Table 1 from Automated Tracking of Nanoparticle-labeled Melanoma Cells Improves the Predictive Power of a Brain Metastasis Model
Authors: Sundstrøm Terje , Daphu Inderjit , Wendelbo Ingvild , Hodneland Erlend , Lundervold Arvid , Immervoll Heike , Skaftnesmo Kai Ove , Babic Michal , Jendelova Pavla , Sykova Eva , Lund-Johansen Morten , Bjerkvig Rolf , Thorsen Frits
Published: April 2023

PDF file - 37K, Tumor take and mean number of tumors in the labeled 105, 5 x 105 and 106 groups and in the unlabeled 106 group at 4, 6 and 8 weeks post injection
Supplementary Movie 2 from Automated Tracking of Nanoparticle-labeled Melanoma Cells Improves the Predictive Power of a Brain Metastasis Model
Authors: Sundstrøm Terje , Daphu Inderjit , Wendelbo Ingvild , Hodneland Erlend , Lundervold Arvid , Immervoll Heike , Skaftnesmo Kai Ove , Babic Michal , Jendelova Pavla , Sykova Eva , Lund-Johansen Morten , Bjerkvig Rolf , Thorsen Frits
Published: April 2023

MP4 file - 1594K, 3D model of melanoma brain metastases in a mouse
Supplementary Methods from Automated Tracking of Nanoparticle-labeled Melanoma Cells Improves the Predictive Power of a Brain Metastasis Model
Authors: Sundstrøm Terje , Daphu Inderjit , Wendelbo Ingvild , Hodneland Erlend , Lundervold Arvid , Immervoll Heike , Skaftnesmo Kai Ove , Babic Michal , Jendelova Pavla , Sykova Eva , Lund-Johansen Morten , Bjerkvig Rolf , Thorsen Frits
Published: April 2023

PDF file - 74K, More details on specific topics from main Materials and Methods, including BRAF mutational status, PPB staining, Scanning electron microscopy, Transmission electron microscopy, Histology and Immunohistochemistry data. Also includes supplementary reference.
Supplementary Figure 3 from Tissue Damage–Associated “Danger Signals” Influence T-cell Responses That Promote the Progression of Preneoplasia to Cancer
Authors: He Ying , Zha Jikun , Wang Yamin , Liu Wenhua , Yang Xuanming , Yu Ping
Published: April 2023

PDF file - 20K, The majority of CD11b+ cells were F4/80+ in the prostate of TRAMP mice
Supplementary Figure 2 from Tissue Damage–Associated “Danger Signals” Influence T-cell Responses That Promote the Progression of Preneoplasia to Cancer
Authors: He Ying , Zha Jikun , Wang Yamin , Liu Wenhua , Yang Xuanming , Yu Ping
Published: April 2023

PDF file - 41K, Few infiltrating immune cells in the prostate of young or old WT mice
Supplementary Figure 1 from Tissue Damage–Associated “Danger Signals” Influence T-cell Responses That Promote the Progression of Preneoplasia to Cancer
Authors: He Ying , Zha Jikun , Wang Yamin , Liu Wenhua , Yang Xuanming , Yu Ping
Published: April 2023

PDF file - 46K, Lymphocytes promote prostate cancer in TRAMP mice
Supplementary Figure Legend from Ex Vivo Activation of CD56+ Immune Cells That Eradicate Neuroblastoma
Authors: Rujkijyanont Piya , Chan Wing Keung , Eldridge Paul W. , Lockey Timothy , Holladay Martha , Rooney Barbara , Davidoff Andrew M. , Leung Wing , Vong Queenie
Published: April 2023

PDF file - 74K, Legend for Supplementary Figure 1
Supplementary Figure 1 from Ex Vivo Activation of CD56+ Immune Cells That Eradicate Neuroblastoma
Authors: Rujkijyanont Piya , Chan Wing Keung , Eldridge Paul W. , Lockey Timothy , Holladay Martha , Rooney Barbara , Davidoff Andrew M. , Leung Wing , Vong Queenie
Published: April 2023

PDF File - 222K, Titration experiments for optimal CD56+:CD56− cell ratio.
Supplementary Figure and Table Legend from Identification of an Aurora Kinase Inhibitor Specific for the Aurora B Isoform
Authors: Xie Hua , Lee Mee-Hyun , Zhu Feng , Reddy Kanamata , Peng Cong , Li Yan , Lim Do Young , Joon Kim Dong , Li Xiang , Kang Soouk , Li Haitao , Ma Weiya , Lubet Ronald A. , Ding Jian , Bode Ann M. , Dong Zigang
Published: April 2023

PDF file - 81K
Supplementary Figure 1 from Identification of an Aurora Kinase Inhibitor Specific for the Aurora B Isoform
Authors: Xie Hua , Lee Mee-Hyun , Zhu Feng , Reddy Kanamata , Peng Cong , Li Yan , Lim Do Young , Joon Kim Dong , Li Xiang , Kang Soouk , Li Haitao , Ma Weiya , Lubet Ronald A. , Ding Jian , Bode Ann M. , Dong Zigang
Published: April 2023

PDF file - 107K, HOI-07 inhibits Akt1 and Akt2 activities in vitro but not in cells. A and B, HOI-07 inhibits in vitro Akt1 (A) and Akt2 (B) kinase activities in a concentration-dependent manner. Akt1 and Akt2 kinase assays were performed using the liquid scintillation method. C and D, Western blot analysis of the expression of Akt downstream signaling molecules in A549 (C) and NCI-H520 (D) cancer cells. No obvious inhibitory activity on the Akt downstream pathway was observed after treatment HOI-07 for 2 h
Supplementary Methods from Cholesterol Loading and Ultrastable Protein Interactions Determine the Level of Tumor Marker Required for Optimal Isolation of Cancer Cells
Authors: Jain Jayati , Veggiani Gianluca , Howarth Mark
Published: April 2023

Supplementary Methods PDF file - 192K,Contains methods for cloning and expression of proteins, flow cytometry, biotinylation, microscopy, statistics and selected magnetic isolation procedures
Supplementary Figure 5 from Therapeutic PD-1 Pathway Blockade Augments with Other Modalities of Immunotherapy T-Cell Function to Prevent Immune Decline in Ovarian Cancer
Authors: Duraiswamy Jaikumar , Freeman Gordon J. , Coukos George
Published: April 2023

PDF file, 41K, Synergistic effect of PD-1 or PD-L1 blockade with vaccination and co-stimulation (TLR 9 ligand) on ovarian ID8 tumor rejection.
Supplementary Tables 1 - 6 from Epigenetic Repression of miR-31 Disrupts Androgen Receptor Homeostasis and Contributes to Prostate Cancer Progression
Authors: Lin Pei-Chun , Chiu Ya-Lin , Banerjee Samprit , Park Kyung , Mosquera Juan Miguel , Giannopoulou Eugenia , Alves Pedro , Tewari Ashutosh K. , Gerstein Mark B. , Beltran Himisha , Melnick Ari M. , Elemento Olivier , Demichelis Francesca , Rubin Mark A.
Published: April 2023

PDF file - 146K, Supplementary Table S1. Differentially expressed 105 miRNAs in PCA. Supplementary Table S2. List of 25 miRNAs differentially expressed with at least 1.5 fold change in PCA. Supplementary Table S3. List of CpG sites examined by MassARRAY EpiTyping. Supplementary Tables S4. Statistic analysis of DNA methylation levels of the miR-31 promoter in matched samples. Supplementary Tables S5. Statistic analysis of DNA methylation levels of the miR-31 promoter in clinical PCA samples. Supplementary Table S6. Top 5 cellular processes altered by miR-31 in LNCaP cells.
Supplementary Figures 1 - 5 from Epigenetic Repression of miR-31 Disrupts Androgen Receptor Homeostasis and Contributes to Prostate Cancer Progression
Authors: Lin Pei-Chun , Chiu Ya-Lin , Banerjee Samprit , Park Kyung , Mosquera Juan Miguel , Giannopoulou Eugenia , Alves Pedro , Tewari Ashutosh K. , Gerstein Mark B. , Beltran Himisha , Melnick Ari M. , Elemento Olivier , Demichelis Francesca , Rubin Mark A.
Published: April 2023

PDF file - 1891K, Supplementary Fig. S1. Identification of 105 differential expressed miRNAs in PCA, deletion analysis for Chr. 9p21.3, and DNA methylation analysis of the miR-31 promoter region Supplementary Fig. S2. AR-signaling negatively regulates the expression of miR-31. Supplementary Fig. S3. miR-31 negatively regulates AR and E2F1. Supplementary Fig. S4. miR-31 directly targets key cell cycle players. Supplementary Fig. S5. miR-31 inhibits growth the VCaP xenografts.
Supplementary Figure Legends from Genome-wide Profiling of AP-1–Regulated Transcription Provides Insights into the Invasiveness of Triple-Negative Breast Cancer
Authors: Zhao Chunyan , Qiao Yichun , Jonsson Philip , Wang Jian , Xu Li , Rouhi Pegah , Sinha Indranil , Cao Yihai , Williams Cecilia , Dahlman-Wright Karin
Published: April 2023

PDF file - 42KB
Supplementary Figure 4 from Genome-wide Profiling of AP-1–Regulated Transcription Provides Insights into the Invasiveness of Triple-Negative Breast Cancer
Authors: Zhao Chunyan , Qiao Yichun , Jonsson Philip , Wang Jian , Xu Li , Rouhi Pegah , Sinha Indranil , Cao Yihai , Williams Cecilia , Dahlman-Wright Karin
Published: April 2023

PDF file - 102KB, Survival analysis of the K-M dataset.
Supplementary Figure 6 from Definition of Molecular Determinants of Prostate Cancer Cell Bone Extravasation
Authors: Barthel Steven R. , Hays Danielle L. , Yazawa Erika M. , Opperman Matthew , Walley Kempland C. , Nimrichter Leonardo , Burdick Monica M. , Gillard Bryan M. , Moser Michael T. , Pantel Klaus , Foster Barbara A. , Pienta Kenneth J. , Dimitroff Charles J.
Published: April 2023

PDF file - 41K, E-selectin ligand+ PC-R1 FT7 cells breach HUVEC under shear flow without exogenous chemokines
Supplementary Figure 2 from Genome-wide Profiling of AP-1–Regulated Transcription Provides Insights into the Invasiveness of Triple-Negative Breast Cancer
Authors: Zhao Chunyan , Qiao Yichun , Jonsson Philip , Wang Jian , Xu Li , Rouhi Pegah , Sinha Indranil , Cao Yihai , Williams Cecilia , Dahlman-Wright Karin
Published: April 2023

PDF file - 86KB, Examination of knockdown efficiency after siRNA transfection and validation of microarray data by real-time PCR.
Supplementary Figure 2 from Definition of Molecular Determinants of Prostate Cancer Cell Bone Extravasation
Authors: Barthel Steven R. , Hays Danielle L. , Yazawa Erika M. , Opperman Matthew , Walley Kempland C. , Nimrichter Leonardo , Burdick Monica M. , Gillard Bryan M. , Moser Michael T. , Pantel Klaus , Foster Barbara A. , Pienta Kenneth J. , Dimitroff Charles J.
Published: April 2023

PDF file - 213K, beta1 and alphaVbeta3 are constitutively active and mediate PCa cell adhesion
Supplementary Table 1 from HDAC6 Inhibition Restores Ciliary Expression and Decreases Tumor Growth
Authors: Gradilone Sergio A. , Radtke Brynn N. , Bogert Pamela S. , Huang Bing Q. , Gajdos Gabriella B. , LaRusso Nicholas F.
Published: April 2023

PDF file - 48K, shRNAs Target Sequences
Supplementary Figure 1 from Definition of Molecular Determinants of Prostate Cancer Cell Bone Extravasation
Authors: Barthel Steven R. , Hays Danielle L. , Yazawa Erika M. , Opperman Matthew , Walley Kempland C. , Nimrichter Leonardo , Burdick Monica M. , Gillard Bryan M. , Moser Michael T. , Pantel Klaus , Foster Barbara A. , Pienta Kenneth J. , Dimitroff Charles J.
Published: April 2023

PDF file - 196K, PCa cells prominently express beta1 and alphaVbeta3 integrins
Supplementary Figure 5 from HDAC6 Inhibition Restores Ciliary Expression and Decreases Tumor Growth
Authors: Gradilone Sergio A. , Radtke Brynn N. , Bogert Pamela S. , Huang Bing Q. , Gajdos Gabriella B. , LaRusso Nicholas F.
Published: April 2023

PDF file - 981K, HDAC6 staining in AccuMax Array A205(II)
Supplementary Figure 1 from HDAC6 Inhibition Restores Ciliary Expression and Decreases Tumor Growth
Authors: Gradilone Sergio A. , Radtke Brynn N. , Bogert Pamela S. , Huang Bing Q. , Gajdos Gabriella B. , LaRusso Nicholas F.
Published: April 2023

PDF file - 1169K, Cilia staining in AccuMax Array A205(II)
Supplementary Figures 1 - 9 from Antitumor Activity of the Selective Pan-RAF Inhibitor TAK-632 in BRAF Inhibitor-Resistant Melanoma
Authors: Nakamura Akito , Arita Takeo , Tsuchiya Shuntarou , Donelan Jill , Chouitar Jouhara , Carideo Elizabeth , Galvin Katherine , Okaniwa Masanori , Ishikawa Tomoyasu , Yoshida Sei
Published: April 2023

PDF file - 614K, Cellular effects of TAK-632, vemurafenib, and TAK-733 on MAPK signaling (S1); Model describing RAF paradoxical activation (S2); Effects of TAK-632 and vemurafenib on BRAF kinase activity (S3); Reversibility of TAK-632 and vemurafenib in living cells (S4); Effects of TAK-632 and vemurafenib on RAF kinase activity in NRAS-mutated cells expressing dimerization-prone RAF mutants (S5); Effect of TAK-632 on MAPK signaling in cells expressing NRASQ61K or deltaN-BRAF (S6) Combined effect of TAK-632 and TAK-733 on cell proliferation in cells bearing wild-type RAF and RAS (S7); Combined effect of TAK-632 and TAK-733 on MAPK signaling in cells expressing NRASQ61K or deltaN-BRAF (S8); Model describing the mechanism of action of a pan-RAF inhibitor (S9).
Supplementary Figure Legend from Antitumor Activity of the Selective Pan-RAF Inhibitor TAK-632 in BRAF Inhibitor-Resistant Melanoma
Authors: Nakamura Akito , Arita Takeo , Tsuchiya Shuntarou , Donelan Jill , Chouitar Jouhara , Carideo Elizabeth , Galvin Katherine , Okaniwa Masanori , Ishikawa Tomoyasu , Yoshida Sei
Published: April 2023

PDF file - 119K
Supplementary Methods, Figures 1 - 6 from Oncogenic Activation of Pak1-Dependent Pathway of Macropinocytosis Determines BCG Entry into Bladder Cancer Cells
Authors: Redelman-Sidi Gil , Iyer Gopa , Solit David B. , Glickman Michael S.
Published: April 2023

PDF file - 270K, Figure S1: Gating strategy for flow cytometry Figure S2: Effect of small-molecule inhibitors on the uptake of fixed BCG Figure S3: Uptake of organisms other than BCG Figure S4: BCG uptake is independent of dynamin and clathrin Figure S5: Effect of dynamin constructs and clathrin shRNA on uptake of fluorescent transferrin Figure S6: Effect of BKM120 on BCG uptake
Supplementary Methods, Figure Legend from Phosphatidylinositol 4-Phosphate in the Golgi Apparatus Regulates Cell–Cell Adhesion and Invasive Cell Migration in Human Breast Cancer
Authors: Tokuda Emi , Itoh Toshiki , Hasegawa Junya , Ijuin Takeshi , Takeuchi Yukiko , Irino Yasuhiro , Fukumoto Miki , Takenawa Tadaomi
Published: April 2023

PDF file - 114K
Supplementary Data from Oncogenic Activation of Pak1-Dependent Pathway of Macropinocytosis Determines BCG Entry into Bladder Cancer Cells
Authors: Redelman-Sidi Gil , Iyer Gopa , Solit David B. , Glickman Michael S.
Published: April 2023

Supplementary Data - PDF file 270K, Supplementary Materials and Methods Figure S1: Gating strategy for flow cytometry Figure S2: Effect of small-molecule inhibitors on the uptake of fixed BCG Figure S3: Uptake of organisms other than BCG Figure S4: BCG uptake is independent of dynamin and clathrin Figure S5: Effect of dynamin constructs and clathrin shRNA on uptake of fluorescent transferrin Figure S6: Effect of BKM120 on BCG uptake
Supplementary Figure 5 from Phosphatidylinositol 4-Phosphate in the Golgi Apparatus Regulates Cell–Cell Adhesion and Invasive Cell Migration in Human Breast Cancer
Authors: Tokuda Emi , Itoh Toshiki , Hasegawa Junya , Ijuin Takeshi , Takeuchi Yukiko , Irino Yasuhiro , Fukumoto Miki , Takenawa Tadaomi
Published: April 2023

PDF file - 274K, Supplementary Figure 5. Knockdown of PI4KIIIbeta in Hs578t cells.
Supplementary Figure 3 from Phosphatidylinositol 4-Phosphate in the Golgi Apparatus Regulates Cell–Cell Adhesion and Invasive Cell Migration in Human Breast Cancer
Authors: Tokuda Emi , Itoh Toshiki , Hasegawa Junya , Ijuin Takeshi , Takeuchi Yukiko , Irino Yasuhiro , Fukumoto Miki , Takenawa Tadaomi
Published: April 2023

PDF file - 229K, Supplementary Figure 3. Knockdown of SAC1 and PI4KIIIbeta in MCF7 cells.
Supplementary Figure Legend from Selective Blockade of Matrix Metalloprotease-14 with a Monoclonal Antibody Abrogates Invasion, Angiogenesis, and Tumor Growth in Ovarian Cancer
Authors: Kaimal Rajani , Aljumaily Raid , Tressel Sarah L. , Pradhan Rutika V. , Covic Lidija , Kuliopulos Athan , Zarwan Corrine , Kim Young B. , Sharifi Sheida , Agarwal Anika
Published: April 2023

PDF file - 62K
Supplementary Figure 1 from Dual Targeting of EGFR and HER3 with MEHD7945A Overcomes Acquired Resistance to EGFR Inhibitors and Radiation
Authors: Huang Shyhmin , Li Chunrong , Armstrong Eric A. , Peet Chimera R. , Saker Jarob , Amler Lukas C. , Sliwkowski Mark X. , Harari Paul M.
Published: April 2023

PDF file - 23KB, Effect of MEHD7945A on cell cycle progression and EGFR/HER3 signaling
Supplementary Materials and Methods, Figure Legends, Figures 1-2, and Tables 1-2 from Generation of Prostate Tumor–Initiating Cells Is Associated with Elevation of Reactive Oxygen Species and IL-6/STAT3 Signaling
Authors: Qu Yi , Oyan Anne Margrete , Liu Runhui , Hua Yaping , Zhang Jigang , Hovland Randi , Popa Mihaela , Liu Xiaojun , Brokstad Karl A. , Simon Ronald , Molven Anders , Lin Biaoyang , Zhang Wei-dong , McCormack Emmet , Kalland Karl-Henning , Ke Xi-Song
Published: April 2023

PDF file 659K, Supplementary Materials and Methods, Figures,and Tables.
Supplementary Data 3 from Generation of Prostate Tumor–Initiating Cells Is Associated with Elevation of Reactive Oxygen Species and IL-6/STAT3 Signaling
Authors: Qu Yi , Oyan Anne Margrete , Liu Runhui , Hua Yaping , Zhang Jigang , Hovland Randi , Popa Mihaela , Liu Xiaojun , Brokstad Karl A. , Simon Ronald , Molven Anders , Lin Biaoyang , Zhang Wei-dong , McCormack Emmet , Kalland Karl-Henning , Ke Xi-Song
Published: April 2023

XLS file 2928K, Changed gene expression in D5HS comparing to EPT2-D5 cells
Supplementary Figure Legend from Proliferation-Independent Control of Tumor Glycolysis by PDGFR-Mediated AKT Activation
Authors: Ran Cong , Liu Huan , Hitoshi Yasuyuki , Israel Mark A.
Published: April 2023

PDF file - 100K
Supplementary Figure 6 from Proliferation-Independent Control of Tumor Glycolysis by PDGFR-Mediated AKT Activation
Authors: Ran Cong , Liu Huan , Hitoshi Yasuyuki , Israel Mark A.
Published: April 2023

PDF file - 90K, Figure S6. Inhibition of AKT activation decreases glycolysis in glioma-derived TSCs.
Supplementary Figure 4 from CSF1R Signaling Blockade Stanches Tumor-Infiltrating Myeloid Cells and Improves the Efficacy of Radiotherapy in Prostate Cancer
Authors: Xu Jingying , Escamilla Jemima , Mok Stephen , David John , Priceman Saul , West Brian , Bollag Gideon , McBride William , Wu Lily
Published: April 2023

PDF file - 1234K, Supplemental figure 4: ABL1 mediates CSF1 expression in other human prostate cancer cell lines.
Supplementary Figure 4 from Proliferation-Independent Control of Tumor Glycolysis by PDGFR-Mediated AKT Activation
Authors: Ran Cong , Liu Huan , Hitoshi Yasuyuki , Israel Mark A.
Published: April 2023

PDF file - 74K, Figure S4. PDGF regulates glycolysis in cell-cycle arrested TSCs.
Supplementary Figure 1 from CSF1R Signaling Blockade Stanches Tumor-Infiltrating Myeloid Cells and Improves the Efficacy of Radiotherapy in Prostate Cancer
Authors: Xu Jingying , Escamilla Jemima , Mok Stephen , David John , Priceman Saul , West Brian , Bollag Gideon , McBride William , Wu Lily
Published: April 2023

PDF file - 13003K, Supplemental figure 1: Local irradiation enhances recruitment of TAMs and MDSCs to tumors in RM-9 model.
Supplementary Table 3 from Cisplatin Hypersensitivity of Testicular Germ Cell Tumors Is Determined by High Constitutive Noxa Levels Mediated by Oct-4
Authors: Gutekunst Matthias , Mueller Thomas , Weilbacher Andrea , Dengler Michael A. , Bedke Jens , Kruck Stephan , Oren Moshe , Aulitzky Walter E. , van der Kuip Heiko
Published: April 2023

PDF file - 39K, siGenome SMARTpool (Dharmacon) siRNA sequences
Supplementary Table 1 from Cisplatin Hypersensitivity of Testicular Germ Cell Tumors Is Determined by High Constitutive Noxa Levels Mediated by Oct-4
Authors: Gutekunst Matthias , Mueller Thomas , Weilbacher Andrea , Dengler Michael A. , Bedke Jens , Kruck Stephan , Oren Moshe , Aulitzky Walter E. , van der Kuip Heiko
Published: April 2023

PDF file - 82K, TaqMan assays
Supplemental Figure 5 from Mast Cell–Derived Prostaglandin D2 Inhibits Colitis and Colitis-Associated Colon Cancer in Mice
Authors: Iwanaga Koichi , Nakamura Tatsuro , Maeda Shingo , Aritake Kosuke , Hori Masatoshi , Urade Yoshihiro , Ozaki Hiroshi , Murata Takahisa
Published: April 2023

Supplemental Figure
Supplementary Figures 1 - 5, Tables 1 - 3 from CD44-Positive Cancer Stem Cells Expressing Cellular Prion Protein Contribute to Metastatic Capacity in Colorectal Cancer
Authors: Du Lei , Rao Guanhua , Wang Hongyi , Li Baowei , Tian Weili , Cui Jiantao , He Leya , Laffin Brian , Tian Xiuyun , Hao Chunyi , Liu Hongmin , Sun Xin , Zhu Yushan , Tang Dean G. , Mehrpour Maryam , Lu Youyong , Chen Quan
Published: April 2023

PDF file - 2531K, Supplementary Figure S1. PrPc is correlated with tumor grade, metastasis and outcomes. Supplementary Figure S2. PrPc co-expresses with CD44 and enriches CSC Supplementary Figure S3. PrPc confers greater metastatic capacity in spleen-to-liver metastasis Supplementary Figure S4. PrPc is functional importance for metastatic capacity Supplementary Figure S5. PrPc induces EMT in CCSCs Supplementary Table 1. Analysis of CD44+PrPc+, CD44+PrPc-, CD44-PrPc+, and CD44-PrPc- subpopulations from 31 CRC patients Supplementary Table 2. Tumor-initiating incidence of CD44+PrPc+, CD44+PrPc-, CD44-PrPc+ and CD44-PrPc- CRC subpopulations Supplementary Table 3. Primers for quantitative PCR
Supplementary Table 1 from Thyroid Hormone Regulation of miR-21 Enhances Migration and Invasion of Hepatoma
Authors: Huang Ya-Hui , Lin Yang-Hsiang , Chi Hsiang-Cheng , Liao Chen-Hsin , Liao Chia-Jung , Wu Sheng-Ming , Chen Cheng-Yi , Tseng Yi-Hsin , Tsai Chung-Ying , Lin Sheng-Yen , Hung Yu-Ting , Wang Chih-Jen , Lin Crystal D. , Lin Kwang-Huei
Published: April 2023

PDF - 57K, Basic clinical characterization of 40 patients with hepatoma.