bluuebunny/crossref_metadata_2025 huggingface dataset:
Measurement Burst Designs to Improve Precision in Peer Research
Authors: Persram Ryan J. , Panarello Bianca , Castellanos Melisa , Astrologo Lisa , Bukowski William M.
Published: September 2021

Measurement burst designs, in which assessments of a set of constructs are made at two or more times in quick succession (e.g., within days), can be used as a novel method to improve the stability of basic measures typically used in longitudinal peer research. In this Element, we hypothesized that the stabilities for adolescent-reported peer acceptance, anxiety, and self-concept would be stronger when using the measurement burst approach versus the single time observation. Participants included youth between 10 and 13 years old who completed (a) sociometric assessments of acceptance, and measures of (b) social and test anxiety, and (c) self-concept across three times with two assessments made at each burst. Findings broadly showed that the stabilities were significantly stronger with the measurement burst when compared to the single time assessment, supporting our main hypothesis. We discuss the utility of the measurement burst in a broader context and considerations for researchers.
Spanwise-coherent hydrodynamic waves around flat plates and airfoils
Authors: Abreu Leandra I. , Tanarro Alvaro , Cavalieri André V.G. , Schlatter Philipp , Vinuesa Ricardo , Hanifi Ardeshir , Henningson Dan S.
Published: September 2021

We investigate spanwise-coherent structures in the turbulent flow around airfoils, motivated by their connection with trailing-edge noise. We analyse well-resolved large-eddy simulations (LES) of the flow around NACA 0012 and NACA 4412 airfoils, both at a Reynolds number of 400 000 based on the chord length. Spectral proper orthogonal decomposition performed on the data reveals that the most energetic coherent structures are hydrodynamic waves, extending over the turbulent boundary layers around the airfoils with significant amplitudes near the trailing edge. Resolvent analysis was used to model such structures, using the mean field as a base flow. We then focus on evaluating the dependence of such structures on the domain size, to ensure that they are not an artefact of periodic boundary conditions in small computational boxes. To this end, we performed incompressible LES of a zero-pressure-gradient turbulent boundary layer, for three different spanwise sizes, with the momentum-thickness Reynolds number matching those near the airfoils trailing edge. The same coherent hydrodynamic waves were observed for the three domains. Such waves are accurately modelled as the most amplified flow response from resolvent analysis. The signature of such wide structures is seen in non-premultiplied spanwise wavenumber spectra, which collapse for the three computational domains. These results suggest that the spanwise-elongated structures are not domain-size dependent for the studied simulations, indicating thus the presence of very wide structures in wall-bounded turbulent flows.
Relationship Between Positive Childhood Experiences and Psychological Resilience in University Students: The Mediating Role of Self-Esteem
Authors: Kocatürk Metin , Çiçek İlhan
Published: September 2021

Childhood experiences can affect individuals’ self-esteem and psychological resilience during personality and psychosocial development in adolescence and adulthood. The effect of positive childhood experiences on adulthood has rarely been investigated, with most studies focusing on negative aspects of childhood. Evidence shows that they also influence the development of psychological resilience and self-esteem. This study examined the relationship between positive childhood experiences, self-esteem, and psychological resilience. A total of 570 university students completed the Positive Childhood Experience Scale, Brief Resilience Scale and Rosenberg Self-Esteem Scale. The results of structural equation modelling indicated that positive experiences significantly predicted self-esteem and resilience. Self-esteem also predicted psychological resilience. Most importantly, positive childhood experiences had an indirect effect on resilience through self-esteem. The results suggest that focusing on positive aspects of childhood is as important and functional as dealing with negative ones to contribute to self-esteem and resilience. We suggest that school psychologists and counsellors could integrate these results into intervention programs to improve resilience through increased self-esteem.
Regionalist Parties in Central Government: A Shift in Ministerial Portfolio Preferences?
Authors: Terrière Lorenzo , Bouteca Nicolas
Published: September 2021

This article takes a closer look at the ministerial representation of peripheral elites in central state institutions. We assess the ministerial portfolios that regionalist parties hold once they enter national government. We use a novel dataset that consists of a large sample of ministerial posts (N=1880) allocated to regionalist parties across Western multilevel democracies throughout the post–World War II period. An empirical analysis shows that regionalist parties control a disproportionately high share of the minister posts, a proportionate share of the policy domains, and a disproportionately low share of the key leadership positions in national cabinets. They have a distinctive preference to hold territorial and institutional (that is, decentralization) responsibilities in their ministerial portfolios. In contrast, concerning secondary policy domains (social-economic and culture-identity) they appear to be highly flexible. Ministerial appointments are an important gateway for peripheral elites to get access to central state institutions. It is also one of the clearest manifestations of (policy) payoffs: portfolios are meaningful tools to defend the interests of a territorial subgroup. Yet, there is no straight line from portfolio distribution to policy outcomes at the end of a legislative term. Resolving this broader question of a party’s influence on public policy requires continued research.
Exploring the relationship between working history, retirement transition and women's life satisfaction
Authors: Tambellini Elisa
Published: September 2021

How does the transition to retirement affect female subjective wellbeing? The major theoretical perspectives that have been applied as frameworks to study the heterogeneous adjustment to retirement include role theory and continuity theory. They have often been integrated with a lifecourse approach, which allows us to study retirement as a transition set inside a lifelong process. In this paper, I assess how working life courses are related to changes in subjective wellbeing before and after retirement, using data from the Survey of Health, Ageing and Retirement in Europe (SHARE) and concentrating on women. Firstly, I conduct sequence analysis and cluster analysis to identify groups of typical working lifecourses from ages 20 to 50. Secondly, regression models estimate how retirement transition is associated with changes in life satisfaction, according to the different working trajectories. The results show that some of the trajectories, constituted of discontinuity or part-time periods, exhibit a continuous increase in life satisfaction, passing from employment (or unemployment) to retirement. For other trajectories, such as the full-time one, retirement seems not to have implications for subjective wellbeing.
Modulating Electron Beam–Sample Interactions in Imaging and Diffraction Modes by Dose Fractionation with Low Dose Rates
Authors: Kisielowski Christian , Specht Petra , Rozeveld Steven J , Kang Joo , Fielitz Alyssa J , Barton David , Salazar Anthony C , Dubon Oscar D , Van Dyck Dirk , Yancey David F
Published: September 2021

Technological opportunities are explored to enhance detection schemes in transmission electron microscopy (TEM) that build on the detection of single-electron scattering events across the typical spectrum of interdisciplinary applications. They range from imaging with high spatiotemporal resolution to diffraction experiments at the window to quantum mechanics, where the wave-particle dualism of single electrons is evident. At the ultimate detection limit, where isolated electrons are delivered to interact with solids, we find that the beam current dominates damage processes instead of the deposited electron charge, which can be exploited to modify electron beam-induced sample alterations. The results are explained by assuming that all electron scattering are inelastic and include phonon excitation that can hardly be distinguished from elastic electron scattering. Consequently, a coherence length and a related coherence time exist that reflect the interaction of the electron with the sample and change linearly with energy loss. Phonon excitations are of small energy (<100 meV), but they occur frequently and scale with beam current in the irradiated area, which is why we can detect their contribution to beam-induced sample alterations and damage.
Development of an Energy-Sensitive Detector for the Atom Probe Tomography
Authors: Bacchi Christian , Da Costa Gérald , Cadel Emmanuel , Cuvilly Fabien , Houard Jonathan , Vaudolon Charly , Normand Antoine , Vurpillot François
Published: September 2021

A position and energy-sensitive detector has been developed for atom probe tomography (APT) instruments in order to deal with some mass peak overlap issues encountered in APT experiments. Through this new type of detector, quantitative and qualitative improvements could be considered for critical materials with mass peak overlaps, such as nitrogen and silicon in TiSiN systems, or titanium and carbon in cemented carbide materials. This new detector is based on a thin carbon foil positioned on the front panel of a conventional MCP-DLD detector. According to several studies, it has been demonstrated that the impact of ions on thin carbon foils has the effect of generating a number of transmitted and reflected secondary electrons. The number generated mainly depends on both the kinetic energy and the mass of incident particles. Despite the fact that this phenomenon is well known and has been widely discussed for decades, no studies have been performed to date for using it as a means to discriminate particles energy. Therefore, this study introduces the first experiments on a potential new generation of APT detectors that would be able to resolve mass peak overlaps through the energy-sensitivity of thin carbon foils.
Unexpected Decrease in TW3 Amplitude During Antarctic Sudden Stratospheric Warming Events as Revealed by SD‐WACCM‐X
Authors: Teng Chen‐Ke‐Min , Gu Sheng‐Yang , Qin Yusong , Dou Xiankang , Li Na , Tang Liang
Published: September 2021

The specified dynamics Whole Atmosphere Community Climate Model with thermosphere and ionosphere extension (SD‐WACCM‐X) was utilized to explore migrating tidal variabilities that occurred during the 2002, 2010, and 2019 Antarctic sudden stratospheric warming (SSW) events. All migrating tides show prominent day‐to‐day variations in the mesosphere and lower thermosphere regions, which can be mainly attributed to each Antarctic SSW event. The westward propagating diurnal tide with zonal wavenumber 1 (DW1) and the westward propagating semidiurnal tide with zonal wavenumber 2 (SW2) show a distinct reduction and an increase during each Antarctic SSW event, respectively. Specifically, the westward propagating terdiurnal tide with zonal wavenumber 3 (TW3) shows an unexpected decrease, which is opposite to the behaviors of TW3 reported during Arctic SSW events. We conclude that the unexpected decrease in TW3 may be mainly caused by the nonlinear interaction between DW1 and SW2, in which DW1 may play a major role. In the ionosphere, the TW3 amplitudes also show a decrease during each Antarctic SSW event, which is in consistency with decreasing tidal amplitudes in the neutral atmosphere. Our study demonstrates that TW3 is also a considerable source for short‐term ionospheric variability during Antarctic SSW events.
Importance of Pressure Changes in High Cloud Area Feedback Due to Global Warming
Authors: Ohno Tomoki , Noda Akira T. , Seiki Tatsuya , Satoh Masaki
Published: September 2021

High clouds have large impacts on the Earth's radiation balance, and a better understanding of their change in warmer climates is essential for climate projection science. Previous studies have focused on the role of large‐scale circulations in high cloud change, and little attention is paid to the local processes in high clouds. Here, we show that the evolution of ice clouds in the upper troposphere due to the cloud microphysical processes is dominated by the collection, sublimation, deposition, and sedimentation using a model with an explicit cloud microphysics scheme. Furthermore, we show that these processes can be enhanced and can lead to the reduction of high clouds in warmer climates through the pressure dependencies of fall speeds of ice particles and the molecular diffusivity of water vapor. Our results highlight the importance of change of the high cloud pressure level in the high cloud area feedback.
Enceladus' Tiger Stripes as Frictional Faults: Effect on Stress and Heat Production
Authors: Pleiner Sládková K. , Souček O. , Běhounková M.
Published: September 2021

We propose a new model of Enceladus' tiger stripes in which the ice shell is modeled as an elastic system with Coulomb‐type frictional interfaces subjected to periodic tidal loading. We find that the diurnal tides produce a complex pattern of stress anomalies, characterized by a length scale of tens of km and the peak values exceeding 100 kPa. Friction delays the response of the system to tidal loading and leads to an asymmetry between the compression and extension phases. This asymmetry results in additional stress, constant in time and comparable in magnitude to the cyclic stress. This static stress field is characterized by compression in the direction perpendicular to the faults and may influence the evolution of the south polar region on geological time scales. The total heat flow generated by friction is 0.1–1 GW, accounting for only a small fraction of the heat power emitted from the tiger stripes.
The Essential Role of Cloud‐Radiation Interaction in Nonrotating Convective Self‐Aggregation
Authors: Fan Yiyuan , Chung Yu To , Shi Xiaoming
Published: September 2021

Convective self‐aggregation in radiative‐convective equilibrium (RCE) is a phenomenon of significant interest because of its potential relevance to the organization of tropical storms. However, some previous theories on RCE instability neglected or simplified cloud‐radiative interaction in theoretical models and suggested that water vapor‐radiation feedback is responsible for destabilizing a homogeneous RCE state. Here, through numerical experiments of nonrotating RCE, we first confirm that the predictions from these theories are valid insomuch that dry patches can form in an initially homogeneous domain with uniform sea‐surface temperature when cloud‐radiation interaction is suppressed or eliminated. However, sustained growth of those dry patches is not guaranteed. Developing deep convective circulation can engulf dry patches, and water vapor feedback is not sufficient for overcoming this barrier. Only when the early‐stage cloud radiative forcing is sufficiently strong can self‐aggregation fully develop. Therefore, cloud‐radiative feedback is essential for the eventual realization of self‐aggregation in nonrotating RCE.
Linking Southern Ocean Mixed‐Layer Dynamics to Net Community Production on Various Timescales
Authors: Li Zuchuan , Lozier M. Susan , Cassar Nicolas
Published: September 2021

Mixed‐layer dynamics exert a first order control on nutrient and light availability for phytoplankton. In this study, we examine the influence of mixed‐layer dynamics on net community production (NCP) in the Southern Ocean on intra‐seasonal, seasonal, interannual, and decadal timescales, using biogeochemical Argo floats and satellite‐derived NCP estimates during the period from 1997 to 2020. On intraseasonal timescales, the shoaling of the mixed layer is more likely to enhance NCP in austral spring and winter, suggesting an alleviation of light limitation. As expected, NCP generally increases with light availability on seasonal timescales. On interannual timescales, NCP is correlated with mixed layer depth (MLD) and mixed‐layer‐averaged photosynthetically active radiation (PAR) in austral spring and winter, especially in regions with deeper mixed layers. Though recent studies have argued that winter MLD controls the subsequent growing season's iron and light availability, the limited number of Argo float observations contemporaneous with our satellite observations do not show a significant correlation between NCP and the previous‐winter's MLD on interannual timescales. Over the 1997–2020 period, we observe regional trends in NCP (e.g., increasing around S. America), but no trend for the entire Southern Ocean. Overall, our results show that the dependence of NCP on MLD is a complex function of timescales.
AMOC Variability and Watermass Transformations in the AWI Climate Model
Authors: Sidorenko D. , Danilov S. , Streffing J. , Fofonova V. , Goessling H. F. , Scholz P. , Wang Q. , Androsov A. , Cabos W. , Juricke S. , Koldunov N. , Rackow T. , Sein D. V. , Jung T.
Published: September 2021

Using the depth (z) and density (ϱ) frameworks, we analyze local contributions to AMOC variability in a 900‐year simulation with the AWI climate model. Both frameworks reveal a consistent interdecadal variability; however, the correlation between their maxima deteriorates on year‐to‐year scales. We demonstrate the utility of analyzing the spatial patterns of sinking and diapycnal transformations through depth levels and isopycnals. The success of this analysis relies on the spatial binning of these maps which is especially crucial for the maps of vertical velocities which appear to be too noisy in the main regions of upwelling and downwelling because of stepwise bottom topography. Furthermore, we show that the AMOC responds to fast (annual or faster) fluctuations in atmospheric forcing associated with the NAO. This response is more obvious in the ϱ than in the z framework. In contrast, the link between AMOC and deep water production south of Greenland is found for slower fluctuations and is consistent between the frameworks.
Prefrontal cortex, amygdala, and threat processing: implications for PTSD
Authors: Alexandra Kredlow M. , Fenster Robert J. , Laurent Emma S. , Ressler Kerry J. , Phelps Elizabeth A.
Published: September 2021

Posttraumatic stress disorder can be viewed as a disorder of fear dysregulation. An abundance of research suggests that the prefrontal cortex is central to fear processing—that is, how fears are acquired and strategies to regulate or diminish fear responses. The current review covers foundational research on threat or fear acquisition and extinction in nonhuman animals, healthy humans, and patients with posttraumatic stress disorder, through the lens of the involvement of the prefrontal cortex in these processes. Research harnessing advances in technology to further probe the role of the prefrontal cortex in these processes, such as the use of optogenetics in rodents and brain stimulation in humans, will be highlighted, as well other fear regulation approaches that are relevant to the treatment of posttraumatic stress disorder and involve the prefrontal cortex, namely cognitive regulation and avoidance/active coping. Despite the large body of translational research, many questions remain unanswered and posttraumatic stress disorder remains difficult to treat. We conclude by outlining future research directions related to the role of the prefrontal cortex in fear processing and implications for the treatment of posttraumatic stress disorder.
Organic nitrogen utilisation by an arbuscular mycorrhizal fungus is mediated by specific soil bacteria and a protist
Authors: Rozmoš Martin , Bukovská Petra , Hršelová Hana , Kotianová Michala , Dudáš Martin , Gančarčíková Kateřina , Jansa Jan
Published: September 2021

Arbuscular mycorrhizal (AM) fungi lack efficient exoenzymes to access organic nutrients directly. Nevertheless, the fungi often obtain and further channel to their host plants a significant share of nitrogen (N) and/or phosphorus from such resources, presumably via cooperation with other soil microorganisms. Because it is challenging to disentangle individual microbial players and processes in complex soil, we took a synthetic approach here to study 15N-labelled chitin (an organic N source) recycling via microbial loop in AM fungal hyphosphere. To this end, we employed a compartmented in vitro cultivation system and monoxenic culture of Rhizophagus irregularis associated with Cichorium intybus roots, various soil bacteria, and the protist Polysphondylium pallidum. We showed that upon presence of Paenibacillus sp. in its hyphosphere, the AM fungus (and associated plant roots) obtained several-fold larger quantities of N from the chitin than it did with any other bacteria, whether chitinolytic or not. Moreover, we demonstrated that adding P. pallidum to the hyphosphere with Paenibacillus sp. further increased by at least 65% the gain of N from the chitin by the AM fungus compared to the hyphosphere without protists. We thus directly demonstrate microbial interplay possibly involved in efficient organic N utilisation by AM fungal hyphae.
DNA metabarcoding reveals the dietary composition in the endangered black-faced spoonbill
Authors: Huang Pei-Yu , Poon Emily Shui Kei , Wong Anson Tsz Chun , So Ivy Wai Yan , Sung Yik-Hei , Sin Simon Yung Wa
Published: September 2021

Extensive loss of natural wetlands caused by changes in land use largely diminishes the food resources essential for the survival of migratory waterbirds. Globally, the decline in waterbird populations in East Asia is the most serious, with 64% of these populations showing a decreasing trend. In this study, we applied DNA metabarcoding to examine the spatiotemporal variations and diversities in the dietary compositions of migratory waterbirds in a natural/artificial wetland complex in Asia. By investigating 110 fecal samples from the endangered black-faced spoonbill (Platalea minor) wintering in the wetland, our results show that P. minor had a broad dietary spectrum. The birds fed on at least 26 species in the classes Actinopterygii and Malacostraca, with Mugiliformes, Cichliformes, and Gobiiformes being the main taxa in their diets. Our results also demonstrated clear patterns of the spatiotemporal variations between the roosting groups and intraspecific variations between the individuals, which potentially reflect some of their feeding habits, and the probable usage of different habitat types in the wetland complex. Using high-throughput sequencing, we were able to elucidate the food resources that are critical to P. minor non-invasively, this method can also be used to provide invaluable information for the conservation of many other waterbird species.
Hemidiaphragmatic paralysis following costoclavicular versus supraclavicular brachial plexus block: a randomized controlled trial
Authors: Hong Boohwi , Lee Soomin , Oh Chahyun , Park Seyeon , Rhim Hyun , Jeong Kuhee , Chung Woosuk , Lee Sunyeul , Lim ChaeSeong , Shin Yong-Sup
Published: September 2021

Costoclavicular brachial plexus block is emerging as a promising infraclavicular approach performed just below the clavicle. However, there are relatively little data regarding the hemidiaphragmatic paralysis (HDP) compared to the commonly performed supraclavicular block. We hypothesized that the incidence of HDP in costoclavicular block is lower than supraclavicular block like classical infraclavicular approach. Eighty patients were randomly assigned to ultrasound-guided supraclavicular (group S) or costoclavicular (group C) block with 25 mL of local anesthetics (1:1 mixture of 1% lidocaine and 0.75% ropivacaine). The primary outcome was the incidence of HDP, defined as less than 20% of fractional change in the diaphragm thickness on ultrasound M-mode. Also, pulmonary function test and chest radiograph were assessed before and after the surgery. The incidence of HDP was 4/35 (11.4%) in the group C and 19/40 (47.5%) in the group S (risk difference, − 36%; 95% CI − 54 to − 17%; P = 0.002). The mean (SD) change of DTF values were 30.3% (44.0) and 56.9% (39.3) in the group C and S, respectively (difference in means, − 26.6%; 95% CI − 45.8 to − 7.4%; P = 0.007). The pulmonary function was more preserved in group C than in group S. The determined diagnostic cut off value of the diaphragm elevation on chest radiograph was 29 mm. Despite the very contiguous location of the two approaches around the clavicle, costoclavicular block can significantly reduce the risk of HDP compared with supraclavicular block.
Microbiota composition and intestinal integrity remain unaltered after the inclusion of hydrolysed Nannochloropsis gaditana in Sparus aurata diet
Authors: Cerezo-Ortega I. M. , Di Zeo-Sánchez D. E. , García-Márquez J. , Ruiz-Jarabo I. , Sáez-Casado M. I. , Balebona M. C. , Moriñigo M. A. , Tapia-Paniagua S. T.
Published: September 2021

The use of lysed microalgae in the diet of carnivorous fish can increase the bioavailability of proteins and bioactive compounds, such as unsaturated fatty acids or vitamins in the digestive tract. These are essential molecules for the proper physiological development of fish in aquaculture. However, some antinutritional components and other undesirable molecules can be released from an excess of microalgae supplied, compromising the integrity of the intestine. The inclusion of small amounts of hydrolized microalgae in the fish diet can be a good strategy to avoid negative effects, improving the availability of beneficial compounds. Nannochloropsis gaditana is an interesting microalgae as it contains nutraceuticals. Previous studies reported beneficial effects after its inclusion in the diet of Sparus aurata, a widely cultured species in Europe and in all Mediterranean countries. However, administration of raw microalgae can produce intestinal inflammation, increased intestinal permeability, bacterial translocation and disturbance of digestion and absorption processes. The aim of this study was to evaluate changes in the intestinal microbiota and barrier stability of S. aurata fed with low inclusion (5%) hydrolysed N. gaditana. Intestinal microbiota was analyzed using Illumina MiSeq technology and libraries were constructed using variable regions V3–V4 of 16S rDNA molecules. Analysis were based in the identification, quantification and comparison of sequences. The predictive intestinal microbial functionality was analyzed with PICRUSt software. The results determined that the intestinal microbiota bacterial composition and the predictive intestinal microbiota functionality did not change statistically after the inclusion of N. gaditana on the diet. The study of gene expression showed that genes involved in intestinal permeability and integrity were not altered in fish treated with the experimental diet. The potential functionality and bacterial taxonomic composition of the intestinal microbiota, and the expression of integrity and permeability genes in the intestine of the carnivorous fish S. aurata were not affected by the inclusion of hydrolysed 5% N. gaditana microalgae.
Physiological responses of Agriophyllum squarrosum and Setaria viridis to drought and re-watering
Authors: Chen Juanli , Zhao Xueyong , Li Yuqiang , Luo Yongqing , Zhang Yaqiu , Liu Mei , Li Yan
Published: September 2021

Drought resistance of psammophyte determines survival and growth, but their responses to drought are not well understood. We conducted a pot experiment to study how physiological characteristics respond to drought and rehydration. We found that watering to 60–65% of field capacity (the control) provided more water than was required by Agriophyllum squarrosum and its leaves became yellow and slightly wilted. The total chlorophyll content and Fm (maximum fluorescence after dark adaptation) in control were lower than in the drought treatment, and both decreased after rehydration. With increasing drought duration and intensity, the relative water content (RWC), chlorophyll content, Fm, and the quantum efficiency of photosystem II (Fv/Fm) of Setaria viridis decreased, but malondialdehyde and membrane permeability increased. During the late drought, the activities of three antioxidant enzymes in A. squarrosum increased to prevent membrane lipid peroxidation; for S. viridis, only peroxidase and superoxide dismutase activities increased. After rehydration, RWC of both species increased, but Fv/Fm of A. squarrosum and Fm of S. viridis did not recover under severe drought. Our research illustrated that A. squarrosum is better adapted to arid environment than S. viridis, but the high soil moisture content is not conducive to normal growth of A. squarrosum.
Target modulation and pharmacokinetics/pharmacodynamics translation of the BTK inhibitor poseltinib for model-informed phase II dose selection
Authors: Byun Joo-Yun , Koh Yi T. , Jang Sun Young , Witcher Jennifer W. , Chan Jason R. , Pustilnik Anna , Daniels Mark J. , Kim Young Hoon , Suh Kwee Hyun , Linnik Matthew D. , Lee Young-Mi
Published: September 2021

The selective Bruton tyrosine kinase (BTK) inhibitor poseltinib has been shown to inhibit the BCR signal transduction pathway and cytokine production in B cells (Park et al.Arthritis Res. Ther.18, 91, https://doi.org/10.1186/s13075-016-0988-z, 2016). This study describes the translation of nonclinical research studies to a phase I clinical trial in healthy volunteers in which pharmacokinetics (PKs) and pharmacodynamics (PDs) were evaluated for dose determination. The BTK protein kinase inhibitory effects of poseltinib in human peripheral blood mononuclear cells (PBMCs) and in rats with collagen-induced arthritis (CIA) were evaluated. High-dimensional phosphorylation analysis was conducted on human immune cells such as B cells, CD8 + memory cells, CD4 + memory cells, NK cells, neutrophils, and monocytes, to map the impact of poseltinib on BTK/PLC and AKT signaling pathways. PK and PD profiles were evaluated in a first-in-human study in healthy donors, and a PK/PD model was established based on BTK occupancy. Poseltinib bound to the BTK protein and modulated BTK phosphorylation in human PBMCs. High-dimensional phosphorylation analysis of 94 nodes showed that poseltinib had the highest impact on anti-IgM + CD40L stimulated B cells, however, lower impacts on anti-CD3/CD-28 stimulated T cells, IL-2 stimulated CD4 + T cells and NK cells, M-CSF stimulated monocytes, or LPS-induced granulocytes. In anti-IgM + CD40L stimulated B cells, poseltinib inhibited the phosphorylation of BTK, AKT, and PLCγ2. Moreover, poseltinib dose dependently improved arthritis disease severity in CIA rat model. In a clinical phase I trial for healthy volunteers, poseltinib exhibited dose-dependent and persistent BTK occupancy in PBMCs of all poseltinib-administrated patients in the study. More than 80% of BTK occupancy at 40 mg dosing was maintained for up to 48 h after the first dose. A first-in-human healthy volunteer study of poseltinib established target engagement with circulating BTK protein. Desirable PK and PD properties were observed, and a modeling approach was used for rational dose selection for subsequent trials. Poseltinib was confirmed as a potential BTK inhibitor for the treatment of autoimmune diseases.

Trial registration: This article includes the results of a clinical intervention on human participants [NCT01765478].
Collagen-derived dipeptide Pro-Hyp administration accelerates muscle regenerative healing accompanied by less scarring after wounding on the abdominal wall in mice
Authors: Jimi Shiro , Koizumi Seiko , Sato Kenji , Miyazaki Motoyasu , Saparov Arman
Published: September 2021

Collagens act as cellular scaffolds in extracellular matrixes, and their breakdown products may also have important biological functions. We hypothesize that collagen dipeptide Pro-Hyp induces favorable healing activities and examined the effects of Pro-Hyp administered via different routes on wound healing using our novel murine model, in which an advanced fibrosis-prone scar lesion was developed in the abdominal muscle wall under the skin. After excising a part of the abdominal wall, a free-drinking experiment was performed using solutions with casein (CS), high molecular weight collagen peptides (HP), and low molecular weight collagen peptides including Pro-Hyp and Hyp-Gly (LP), in addition to water (HO). On day 21 of the study, when compared to the HO and CS groups, muscle regeneration in the LP group was significantly advanced in the granulation tissue, which was associated with a decrease in fibrosis. To clarify the effects of Pro-Hyp, daily intraperitoneal administration of pure Pro-Hyp was performed. Pro-Hyp administration induced many myogenically differentiated cells, including myogenin-positive myoblasts and myoglobin-positive myocytes, to migrate in the granulation tissue, while scar tissue decreased. These results indicated that Pro-Hyp administration accelerates muscle regenerative healing accompanied by less scarring after wounding on the abdominal wall.
Presence of male mitochondria in somatic tissues and their functional importance at the whole animal level in the marine bivalve Arctica islandica
Authors: Dégletagne Cyril , Abele Doris , Glöckner Gernot , Alric Benjamin , Gruber Heike , Held Christoph
Published: September 2021

Metazoans normally possess a single lineage of mitochondria inherited from the mother (♀-type mitochondria) while paternal mitochondria are absent or eliminated in fertilized eggs. In doubly uniparental inheritance (DUI), which is specific to the bivalve clade including the ocean quahog, Arctica islandica, ♂-type mitochondria are retained in male gonads and, in a few species, small proportions of ♂-type mitochondria co-exist with ♀-type in somatic tissues. To the best of our knowledge, we report, for the first time in metazoan, the natural occurrence of male and female individuals with exclusively ♂-type mitochondria in somatic tissues of the bivalve A. islandica. Mitochondrial genomes differ by ~5.5% at DNA sequence level. Exclusive presence of ♂-type mitochondria affects mitochondrial complexes partially encoded by mitochondrial genes and leads to a sharp drop in respiratory capacity. Through a combination of whole mitochondrial genome sequencing and molecular assays (gene presence and expression), we demonstrate that 1) 11% of individuals of an Icelandic population appear homoplasmic for ♂-type mitochondria in somatic tissues, 2) ♂-type mitochondrial genes are transcribed and 3) individuals with ♂-type mitochondria in somatic cells lose 30% of their wild-type respiratory capacity. This mitochondrial pattern in A. islandica is a special case of DUI, highlighted in individuals from both sexes with functional consequences at cellular and conceivably whole animal level.
Standing shock prevents propagation of sparks in supersonic explosive flows
Authors: von der Linden Jens , Kimblin Clare , McKenna Ian , Bagley Skyler , Li Hsiao-Chi , Houim Ryan , Kueny Christopher S. , Kuhl Allen , Grote Dave , Converse Mark , Vossen Caron E. J. , Stern Sönke , Cimarelli Corrado , Sears Jason
Published: September 2021

Volcanic jet flows in explosive eruptions emit radio frequency signatures, indicative of their fluid dynamic and electrostatic conditions. The emissions originate from sparks supported by an electric field built up by the ejected charged volcanic particles. When shock-defined, low-pressure regions confine the sparks, the signatures may be limited to high-frequency content corresponding to the early components of the avalanche-streamer-leader hierarchy. Here, we image sparks and a standing shock together in a transient supersonic jet of micro-diamonds entrained in argon. Fluid dynamic and kinetic simulations of the experiment demonstrate that the observed sparks originate upstream of the standing shock. The sparks are initiated in the rarefaction region, and cut off at the shock, which would limit their radio frequency emissions to a tell-tale high-frequency regime. We show that sparks transmit an impression of the explosive flow, and open the way for novel instrumentation to diagnose currently inaccessible explosive phenomena.
M(B(SeO3)3)H2O (M = Al, Ga): the first boroselenites with a unique sandwich like double-layer structure
Authors: Cao Ming-Yang , Hu Chun-Li , Kong Fang , Xiong Zhe-Yao , Mao Jiang-Gao
Published: September 2021

M(B(SeO3)3)H2O (M = Al, Ga) possesses a unique sandwich type double-layer structure formed by two [MSe2O8]5− 2D layers interconnected by [BSeO5]3− 1D chains, large band gaps and moderate birefringences.
An NMR-based metabolomics study on sea anemones Exaiptasia diaphana (Rapp, 1829) with atrazine exposure
Authors: Jiang Lin , Sullivan Hunter , Seligman Cole , Gilchrist Sandra , Wang Bo
Published: September 2021

NMR metabolomics was performed on E. diaphana exposed to atrazine, and glutamate was discovered as a potential early biomarker.
Effect of Increased Daily Cochlear Implant Use on Auditory Perception in Adults
Authors: Holder Jourdan T. , Gifford René H.
Published: September 2021

Purpose

Despite the recommendation for cochlear implant (CI) processor use during all waking hours, variability in average daily wear time remains high. Previous work has shown that objective wear time is significantly correlated with speech recognition outcomes. We aimed to investigate the causal link between daily wear time and speech recognition outcomes and assess one potential underlying mechanism, spectral processing, driving the causal link. We hypothesized that increased CI use would result in improved speech recognition via improved spectral processing.

Method

Twenty adult CI recipients completed two study visits. The baseline visit included auditory perception testing (speech recognition and spectral processing measures), questionnaire administration, and documentation of data logging from the CI software. Participants watched an educational video, and they were informed of the compensation schedule. Participants were then asked to increase their daily CI use over a 4-week period during everyday life. Baseline measures were reassessed following the 4-week period.

Results

Seventeen out of 20 participants increased their daily CI use. On average, participants’ speech recognition improved by 3.0, 2.4, and 7.0 percentage points per hour of increased average daily CI use for consonant–nucleus–consonant words, AzBio sentences, and AzBio sentences in noise, respectively. Questionnaire scores were similar between visits. Spectral processing showed significant improvement and accounted for a small amount of variance in the change in speech recognition values.

Conclusions

Improved consistency of processor use over a 4-week period yielded significant improvements in speech recognition scores. Though a significant factor, spectral processing is likely not the only mechanism driving improvement in speech recognition; further research is warranted.
Cross‐cultural analysis of the correlation between musical elements and emotion
Authors: Wang Xin , Wei Yujia , Yang Dasheng
Published: September 2021

In a cross‐cultural context, exploring musical elements' cultural specificity and universality that affect various types of music is conducive to personalised emotion recognition. In this study, high‐level musical elements are introduced to explore their influence on emotional perception. By comparing music emotion recognition (MER) models of varied cultural music, musical elements with cultural universality and cultural specificity are further determined. Participants rated valence, tension arousal, and energy arousal on labelled nine‐point analogical–categorical scales for four types of classical music: Chinese ensemble, Chinese solo, Western ensemble, and Western solo. Fifteen musical elements in five categories—timbre, rhythm, articulation, dynamics, and register were annotated through manual evaluation or the automatic algorithm. The relationship between music emotion and musical elements was analysed through partial least squares regression. Results showed that tempo, rhythm complexity, and articulation are culturally universal; musical elements related to timbre, register, and dynamics features are culturally specific. By increasing tempo, rhythm complexity, staccato, perception of valence, tension arousal, and energy arousal can be effectively improved. Based on the Partial least squares regression (PLSR) model's results for the datasets, the combination of manual and automatic annotation for musical elements can improve the MER system's performance.
Supply chain control towers: Technology push or market pull—An assessment tool
Authors: Patsavellas John , Kaur Rashmeet , Salonitis Konstantinos
Published: September 2021

As digital technology and connectivity advance rapidly, the premise of bringing supply chain (SC) visibility across multiple tiers of supply, whilst facilitating the velocity to achieve strategic business objectives, is gaining interest. The feasibility and timing for successful adoption and implementation of such technology depend primarily on the readiness level and specific needs of each organisation, making it imperative to exercise insightful judgement as it can be expensive to acquire, develop and master. This research study examines the market pull versus technology push components of the functionalities enabled by digital SC control towers and buildings on the outcome of an extensive survey and expert interviews and proposes an assessment tool to aid decision making for the consideration of their adoption.
Performance Evaluation of a Novel Hydro - Pneumatic Suspension System of a Heavy Truck on Ride Comfort
Authors: Long Le Xuan , Ha Dang Viet , Van Quynh Le , Van Cuong Bui , Hien Vu Thi
Published: September 2021

The purpose of this work is to evaluate the performance of novel hydrfo-pneumatic suspension system (HPSs) in comparison with traditional hydro-pneumatic fsuspension system (HPSs) of a heavy truck in the direction of improving vehicle ride comfort. Firstly, the nonlinear dynamic models of the traditional and novel HPS systems are set up to determine the vertical forces. And then, the vertical forces are connected with a 3-D nonlinear dynamic model of heavy truck with 10 degrees of freedom under random excitation of road surface. The root mean square (RMS) acceleration responses of the vertical cab, pitch and roll angles of the cab (awzcb, awfcb and awtcb) based on the International Standard ISO 2631-1: 1997 are chosen as objective functions. The study results show that the awzcb, awfcb and awtcb values with novel HPSs reduce by 28.27%, 28.32% and 6.89% in comparison with traditional HPSs when vehicle moves on ISO class D road surface at vehicle speed of 50 km/h and full load. Finally, the ride performance of novel HPSs is verified and compared and evaluated with traditional HPSs under different operating conditions and the evaluation results are also indicated that the ride performance of a novel HPSs is better than the traditional HPSs under survey conditions.
Formation of the vegetation cover in the desert pasture phytocenoses
Authors: Khamroyev Khusen , Abdullayev Obidjon
Published: September 2021

Rising global temperatures in recent years have led to a sharp increase in the area of desert areas. Desert areas are widely used as pastures. The productivity of desert pastures in Uzbekistan is very low, ie 1-3 ts/ha. This limits the year-round use of desert pastures. One of the resource-saving and long-term effective ways to increase their productivity is to plant enclosures, as well as reclamation and forage rows in these desert pastures using plants such as Haloxylon aphyllum, Calligonum caput-medusae, Salsola paletzkiana. This is because protected areas have been scientifically proven to show their positive properties in other areas (around mountainous and irrigated fields). In these areas, enclosures not only perform a protective function, but also serve as a source of fodder for livestock in the autumn-winter seasons.
Study on technological properties of winter wheat soils
Authors: Ravshanov Hamrokul , Mamatov Farmon , Primov Odil , Khazratkulova Shakhnoza , Baratov Dilshod
Published: September 2021

The aim of the study is to study and analyze the physical, mechanical and technological properties of soils from under winter grain crops in the hot climate of Uzbekistan. The results of determining the moisture content, density, hardness and resistance to various deformations of soils after harvesting winter wheat are presented. The basic principles and methods of classical mechanics, mathematical analysis and statistics were used in this study. Studies have found that, in the layer 0-30, the soil moisture for ten days after harvesting winter cereals decreases by 12.1-16.3%, and the soil hardness increases by 10.7-16.4% and are 3.22-5.14 MPa. At the same time, at an average humidity of 12-14%, the resistance of the soil to breakage and torsion, respectively, is 1.3-1.8 and 1.0-1.1 times higher than the resistance of the soil to shear. The resistance of the soil to shear is 87.9 kPa, and to breakage and torsion-69.7 and 78.6 kPa, respectively.
Integrated studies of the physical and mechanical properties of cotton fabric
Authors: Saydalieva Nodira , Khudayberdieva Dilfuza , Isamukhamedova Feruza , Shin Illarion
Published: September 2021

The nature of the adhesive forces of the K-4 preparation is manifested in the occurrence of hydrogen bonds between molecules, as a substance with a sufficiently developed ability to form hydrogen bonds with cellulose. By the method of a one-factor experiment, the regularities of the influence of the concentration of the preparation alkaline-hydrolyzed PAN product on shrinkage, the total opening angle and weight gain of the fabric were revealed. It was found that the concentration of the preparation, equal to 75 g/l, provides the minimum shrinkage and rinsability of the sizing, as well as at the same time the largest value of TOA.
Theoretical and experimental analysis of the process of discretization of cotton fiber in OE spinning
Authors: Akhmedov Kamol , Matismailov Saypila , Mardonov Botir , Yuldashev Alisher
Published: September 2021

This article examines the influence of the parameters of the coating teeth of the discrete drum on the quality of the OE yarn. Based on the analysis of the conditions for retention of fibers by the covering teeth of the discrete drum, equations were obtained to determine the angle of inclination of the teeth. To determine the effect of the coating parameters of the discrete drum teeth on yarn quality, experiments were performed using the Full Factor Experiments mathematical planning method, and a regression equation was obtained for each variable. As a result, the optimal values of the discretization drum coating teeth of the OE spinning machine were determined.
The Young Minds Leadership Meeting 2021 a virtual experience
Authors: Zeltner Richard , Mkrtchyan Hripsime , Martín Valderrama Carmen
Published: September 2021

The Young Minds (YM) programme of the European Physical Society (EPS) was initiated 10 years ago, with the goal to connect young students and researchers all over Europe and to support their professional and personal growth.
Spectroscopy of antihydrogen
Authors: Madsen Niels
Published: September 2021

In 2017 the first observation of an optical transition in an anti-atom was announced by the ALPHA collaboration. This marked a new era in using precision measurements to help unravel one of the most profound questions of modern physics; why the Universe is predominantly made of matter.
The many faces (phases) of strong correlations
Authors: Paschen Silke , Si Qimiao
Published: September 2021

There has been considerable recent progress in discovering and understanding quantum phases and fluctuations produced by strong correlations. Heavy fermion systems are an ideal platform for systematic studies because low and competing energy scales make them highly tunable. As such the phases (faces) of strong correlations transform continuously into one another.