bluuebunny/crossref_metadata_2025 huggingface dataset:
Clinical features and outcome of infection-related glomerulonephritis with IgA deposits
Authors: Miquelestorena-Standley Elodie , Jaulerry Charlotte , Machet Marie-Christine , Rabot Nolwenn , Barbet Christelle , Hummel Aurélie , Karras Alexandre , Garrouste Cyril , Crepin Thomas , Ducloux Didier , Cousin Maud , Albert Catherine , Rivalan Joseph , Gall Emilie Cornec Le , Pourreau François , Deltombe Clément , Nochy Dominique , Szlavik Nora , Felix Sophie , Croué Anne , Buob David , Rioux-Leclerc Nathalie , Doucet Laurent , Goujon Jean-Michel , Renaudin Karine , Rabant Marion , Halimi Jean-Michel
Published: February 2020

Background Infection-related glomerulonephritis with IgA deposits (IRGN-IgA) is being more widely recognized but the precise epidemiology and outcome is lacking, particularly in Europe. We aimed to assess clinical, pathologic and outcome data of IRGN-IgA. Methods Clinical and outcome data from patients from 11 French centers over the 2007-2017 period were retrospectively collected. We reviewed pathologic patterns and immunofluorescence of renal biopsies and evaluated C4d expression in IRGN-IgA. We analyzed correlation between histological presentation and outcome using the Chi square test (qualitative data) and Kruskal-Wallis test (quantitative data). Results Twenty-seven patients (23 men, mean age: 62 ± 15 years) were included. Most of them had a Staphylococcus aureus infection (77.8%) and 44.4% were diabetic. At the time of biopsy, 95.2% had haematuria, 48.1% had a serum creatinine >4 mg/dL, and 16% had a hypocomplementemia. The most common pathologic presentation included mesangial (88.9%) and endocapillary proliferative glomerulonephritis (88.9%) with interstitial fibrosis with tubular atrophy (IF/TA) (85.1%). Diffuse and global glomerular C4d expression, found in 17.8% of the cases, was most frequently observed in biopsies with acute or subacute pattern and associated with a shorter delay between infection and renal biopsy compared to segmental and focal staining. After a median follow-up of 13.2 months, 23.1% died, 46.2% had persistent renal dysfunction and 15.4% reached end-stage renal disease. Renal outcome was correlated to IF/TA severity. Conclusions Infection-related glomerulonephritis with IgA deposits is usually associated with Staphyloccus infections and mainly affects adult men. This entity has a poor prognosis which is correlated to interstitial fibrosis and tubular atrophy severity.
Non-immune-mediated versus immune-mediated type 1 diabetes diagnosis and long-term differences. Retrospective analysis.
Authors: Catarino Diana , Silva Diana , Guiomar Joana , Ribeiro Cristina , Ruas Luísa , Cardoso Luís , Paiva Isabel
Published: February 2020

Background

The American Diabetes Association proposed two subcategories for type 1 diabetes mellitus : type 1A or immune-mediated diabetes (IDM) and type 1B or idiopathic diabetes. The absence of β-cell autoimmune markers, permanent insulinopenia and prone to ketoacidosis define the second category, whose pathogenesis remains unclear. Only a minority of patients fall into this category, also designated non-immune-mediated (NIDM), which is considered by several authors similar to type 2 diabetes. The aim of this study is to evaluate differences at the diagnosis and ten years later of two categories.

Methods

Retrospective cohort study of patients with β-cell autoimmune markers performed at diagnosis and undetectable c-peptide. Were excluded patients with suspicion of another specific type of diabetes. We obtained two groups: IDM (≥ 1 positive antibody) and NIDM (negative antibodies). Age, family history, anthropometry, duration of symptoms, clinical presentation, blood glucose at admission, A1C, lipid profile, arterial hypertension, total diary dose of insulin (TDDI), microvascular and macrovascular complications were evaluated. Results were considered statistically significant with p<0.05.

Results

37 patients, 29 with IDM and 8 patients with NIDM. The age of diagnosis of IDM group (23 years) was significantly different (p=0.004) from the NIDM group (38.1).

The body mass index (BMI) at the diagnosis did not differ significantly (p=0.435). The duration of symptoms was longer in the NIDM (p=0.003). The disease presentation (p=0.744), blood glucose (p=0.482) and HbA1C (p=0.794) at admission and TDID at discharge (p=0.301) did not differ significantly. Total and LDL cholesterol levels were higher in NIDM group but did not differ significantly (p=0.585 and p=0.579, respectively).

After ten years BMI did not differ between groups(p=0.079). Patients with IDM showed a significantly higher HbA1C (p=0,008) and TDID (p=0.017). Relative to the lipid profile, there was no significant difference, however the LDL cholesterol and triglycerides were higher on the NIDM group, as the percentage of hypertension.

Microvascular complications were higher in the IDM group, but no significant difference was found.

Conclusion

Patients with IDM had a poor metabolic control and higher insulin requirement. Patients with NIDM were older and showed higher cardiovascular risk, resembling a clinical phenotype of type 2 diabetes.
Shared transcriptomic responses of Aedes aegypti to arboviral infections : example of dengue and Rift Valley fever viruses
Authors: LICCIARDI Séverine , LOIRE Etienne , CARDINALE Eric , GISLARD Marie , DUBOIS Emeric , CETRE-SOSSAH Catherine Béatrice
Published: February 2020

BackgroundArthropod borne virus infections cause several emerging and resurgent infectious diseases. Among the diseases caused by arboviruses, dengue and Rift Valley fever are responsible for a high rate of severe human diseases worldwide. Understanding the effects of viral infection on gene expression in the mosquito is crucial to the development of early diagnostic tools and may enable researchers and policy makers to better anticipate outbreaks in the next future. Methods Here we investigate the alterations in gene expression across the entire Aedes aegypti genome during infection with DENV and RVF over time.ResultsWe describe several up-regulated genes that share a similar expression profile during infection with both viruses at early and late phases of infection. Family B and D clip-domain serine proteases (CLIP) are clearly overrepresented as well as C-type lectins and transferrin. ConclusionsOur results provide an extensive amount of data highlighting viral gene targets in the mosquito during infection. This data may also be used to develop broad-spectrum anti-viral diagnostic tools based on mosquitoes rather than the mammalian hosts and would help to predict and manage the emergence of outbreaks.
Lorentz symmetry fractionalization and dualities in (2+1)d
Authors: Hsin Po-Shen , Shao Shu-Heng
Published: February 2020

We discuss symmetry fractionalization of the Lorentz group in
(2+1)dd
non-spin quantum field theory (QFT), and its implications for dualities.
We prove that two inequivalent non-spin QFTs are dual as spin QFTs if
and only if they are related by a Lorentz symmetry fractionalization
with respect to an anomalous \mathbb{Z}_2ℤ2
one-form symmetry. Moreover, if the framing anomalies of two non-spin
QFTs differ by a multiple of 8, then they are dual as spin QFTs if and
only if they are also dual as non-spin QFTs. Applications to summing
over the spin structures, time-reversal symmetry, and level/rank
dualities are explored. The Lorentz symmetry fractionalization naturally
arises in Chern-Simons matter dualities that obey certain spin/charge
relations, and is instrumental for the dualities to hold when viewed as
non-spin theories.
Preparation, characterization of fish scales biochar and their applications in the removal of anionic indigo carmine dye from aqueous solutions
Authors: Achieng George O. , Kowenje Chrispin O. , Lalah Joseph O. , Ojwach Stephen O.
Published: February 2020

The preparation and applications of Tilapia (Oreochromis niloticus) fish scale biochars (FSB) as an adsorbent in the removal of indigo carmine dye (ICD) from aqueous solutions is described. The biochars were prepared through pyrolysis over a temperature range of 200 °C–800 °C and characterized for surface charge, functional groups, thermal stability, particle size and morphology, elemental composition, crystallinity, and surface area by using pHpzc, Fourier transform infrared (FTIR) spectroscopy, thermo-gravimetric analysis (TGA), transmission electron microscopy/scanning electron microscopy (TEM/SEM), energy dispersive X-ray (EDX) spectroscopy, powder X-ray diffraction (PXRD) and Brunauer-Emmett-Teller (BET) techniques, respectively. Batch experiments were carried out to determine the variation of adsorption process with initial dye concentration, contact time, initial solution pH, adsorbent load, temperature and adsorbent pyrolysis temperature on the removal of the dye. The percentage removal increased with increase in initial dye concentration and adsorbent dosage. A pH of 2 was the most appropriate for the adsorption experiments. The equilibrium data fitted pseudo-first-order kinetics and Freundlich models, while the thermodynamic parameters confirmed that the adsorption process was endothermic.
Dünya’da ve Türkiye’de Doğa Korumanın Kuramsal Temelleri
Authors: Koç Yasin , Soykan Abdullah
Published: February 2020

İnsanın yeryüzünü en başta tarım sonrasında ise sanayi ve diğer teknolojilerle değişime uğratması ve dünya nüfusunun süreklilik arz eden bir şekilde artış göstermesi insan-çevre ilişkilerinde yeni bakış açısının ortaya çıkmasını doğurmuştur. Özellikle 1970’lerden sonra artan çevrecilik faaliyetleriyle birlikte zengin ekosistemleri ve biyoçeşitliliği sahip doğal alanları ve peyzajları güvence altına alarak gelecek nesillere aktarma düşüncesi ön plana çıkmıştır. Bu durum gerek merkezi hükümetler gerekse uluslararası örgütlerce çeşitli tedbirlerin alınmasıyla bazı önemli yapısal sorunların gündeme gelmesine neden olmuştur. Süregiden tartışmaların temelinde doğanın kimden ve nasıl korunacağı yatmaktadır. Bu bağlamda çalışmanın konusu dünyada ve Türkiye’de doğa korumanın tarihi süreçte geçirdiği kuramsal değişimlerdir. Çalışma böylelikle Türkiye’de doğa koruma faaliyetlerindeki mevcut durumun dünyadaki yaklaşımlarla benzerlik ve farklılıklarını ortaya koymayı amaçlamaktadır. 1970’li yıllardan sonra dünyada insansız doğa koruma yaklaşımı büyük ölçüde terk edilmiş, kırsal kalkınma ve diğer yararlanma düşünceleri neredeyse biyoçeşitliliği koruma ilkesinin önüne geçmiştir. Türkiye’de de benzer eğilimlerin ortaya çıktığı ancak kırsal kalkınma, eko turizm gibi pratiklerin gerçekten söz konusu alanlarda amacına ulaşıp ulaşmadığı doğa koruma literatüründe önemli bir eksiklik olarak dikkat çekmektedir. Bu bağlamda denilebilir ki koruma-kullanma ve kırsal kalkınma pratiklerinin ilişkisini, ortaya çıkan sorunları ortaya koymak için korunan alanların özgün kültürel ve doğal özelliklerini göz önüne alan daha fazla sayıda idiyografik karakterli nitel çalışmaya ihtiyaç vardır.
The Medical Device Applied to Uterine Fibroids Morcellation: Analysis of Critical Biological Issues and Drawbacks from A Medical-Legal Prospective
Authors: Mynbaev Ospan A. , Sparic Radmila , Stark Michael , Malvasi Antonio , Marinelli Enrico , Zaami Simona , Tinelli Andrea
Published: February 2020

Following the FDA safety communication of 2014 increasing attention has been to the treatment of uterine fibroids, due to the suspicion of a potential leiomyosarcoma (ULM). FDA banned the use of power morcellation in the US, since this technique is likely to spread malignant cells from an unsuspected ULM. We criticized the medical legal consequences of this banning among gynecologists and patients, focusing on the drawbacks of biology and surgery. The authors analyzed literature data on one side, on the incidence, diagnosis and treatment of leiomyoma and ULM, and the other side, on the power morcellations and related critical issues, trying to highlight their main controversial aspects and to outline the possible impact on patients and on medical responsibility. The alternative methods to power morcellation are more invasive surgical solutions (as mini laparotomy or culdotomy), which inevitably involve associated risks with the surgical procedure as such and always request the containing bags. Although the in-bag morcellation is a promising technique, currently the used devices are largely off-label. This highlights the surgical risk, in case of complications, of suffering for malpractice claims both for not having used a containment system, favoring the spread of the neoplasm, and for its off-label use. Since the diagnosis of ULM is by histology after surgery, the fear of legal consequences or medical malpractice for unknown ULM power morcellation, should be targeted to analyze, in terms of cost/benefit ratio, the surgical priority. It should focus on the prevention of the risk of having a rare and statistically limited ULM or on the surgical-related complications, often linked to a slowdown minimally invasive surgery, or on the use of the authorized in-bag morcellations.
Electrochemical Detection of Neurotransmitters in the Brain and Other Molecules with Biological Activity in the Nervous System: Dopamine Analysis
Authors: Bustos Erika , Manríquez Juan , Colín-González Ana Laura , Rangel-López Edgar , Santamaría Abel
Published: February 2020

Monitoring the appropriate functions of the brain is a priority when the diagnosis of neurological diseases is carried out. In this regard, there are different analytical techniques to detect neurotransmitters and other molecules with biological activity in the nervous system. Among several analytical procedures, electrochemical techniques are very important since they can be applied in situ, without loss of sensibility and/or minimal handling of samples. In addition, it is also possible to combine them with specific detectors designed on the basis of chemically-modified electrodes in order to improve detection limits by promoting molecular recognition capabilities at their surfaces, thus favoring the development of electrochemical detection in vivo by microelectrodes. In this mini-review, we will describe the major characteristics of this analytical method and its advantages for the detection of neurotransmitters (mostly dopamine) in vivo.
Consensus Analyses in Molecular Docking Studies Applied to Medicinal Chemistry
Authors: dos Santos Maia Mayara , Soares Rodrigues Gabriela Cristina , Silva Cavalcanti Andreza Barbosa , Scotti Luciana , Scotti Marcus Tullius
Published: February 2020

The increasing number of computational studies in medicinal chemistry involving molecular
docking has put the technique forward as promising in Computer-Aided Drug Design. Considering the
main method in the virtual screening based on the structure, consensus analysis of docking has been
applied in several studies to overcome limitations of algorithms of different programs and mainly to
increase the reliability of the results and reduce the number of false positives. However, some consensus
scoring strategies are difficult to apply and, in some cases, are not reliable due to the small number
of datasets tested. Thus, for such a methodology to be successful, it is necessary to understand why,
when and how to use consensus docking. Therefore, the present study aims to present different approaches
to docking consensus, applications, and several scoring strategies that have been successful
and can be applied in future studies.
Effect of Steroidal Hormone Pregnenolone on Proliferation and Differentiation of MC3T3-E1 Osteoblast like Cells
Authors: Badran Serene Adnan , Atia-tul-Wahab  , Fayyaz Sharmeen , Muhammad Bushra Taj , Choudhary Muhammad Iqbal
Published: February 2020

Background:

Bone remodeling is a complex process that includes continuous resorption
by osteoclast cells and bone formation by osteoblast cells. Bone fragility is a common health issue
of the elderly population, particularly in postmenopausal women. It has been established that steroidal
hormones have an important role in bone homeostasis. Therefore hormone replacement therapy
could have beneficial effects on bone health as compared to other treatments.

Objectives:

An imbalance between the rate of bone formation and bone resorption leads to the fragility
of bones. During the current study, we aimed to explore the ability of pregnenolone (1) (PRE),
on proliferation and differentiation of MC3T3-E1 cells. We further aimed to investigate the underlying
mechanism of action for the anabolic effect of PRE (1).

Methods:

The effects of pregnenolone (1) on proliferation, differentiation, and mineralization of
MC3T3 osteoblast-like cells were determined. Cell viability was analyzed using MTT assay and
flow cytometry. ALP activity and alizarin staining were employed to evaluate the effect of pregnenolone
on osteoblast differentiation. Moreover, western blot for analysis of certain important proteins,
crucial for the regulation of bone homeostasis, such as BMP2 and RANKL, was also performed.

Results:

Our results showed that pregnenolone (1) at a concentration of 5 μM
caused a significant (p< 0.05) rise in the growth of MC3T3-E1 cells, whereas a comparable effect
was observed in osteoblast differentiating assays. A significant decrease in RANKL expression was
observed at (0.04 – 1 .M). Our results, therefore, indicated the possible role of pregnenolone (1) in
positive regulation of bone homeostasis by suppressing RANKL expression.

Conclusion:

Taken together, our results indicate that pregnenolone (1) has the potential to enhance
osteoblast proliferation, as inferred from the increased number of cells. These results demonstrated that
pregnenolone (1) could be a potential anabolic agent for the treatment of fragility related disorders.
Deep Novo A+: Improving the Deep Learning Model for De Novo Peptide Sequencing with Additional Ion Types and Validation Set
Authors: Di Lei , He Yongxing , Lu Yonggang
Published: February 2020

Background:

De novo peptide sequencing is one of the key technologies in proteomics,
which can extract peptide sequences directly from tandem mass spectrometry (MS/MS) spectra
without any protein databases. Since the accuracy and efficiency of de novo peptide sequencing can
be affected by the quality of the MS/MS data, the DeepNovo method using deep learning for de
novo peptide sequencing is introduced, which outperforms the other state-of-the-art de novo
sequencing methods.

Objective:

For superior performance and better generalization ability, additional ion types of spectra
should be considered and the model of DeepNovo should be adaptive.

Methods:

Two improvements are introduced in the DeepNovo A+ method: a_ions are added in the
spectral analysis, and the validation set is used to automatically determine the number of training
epochs.

Results:

Experiments show that compared to the DeepNovo method, the DeepNovo A+ method can
consistently improve the accuracy of de novo sequencing under different conditions.

Conclusion:

By adding a_ions and using the validation set, the performance of de novo sequencing
can be improved effectively.
An Overview on Promising Nanotechnological Approaches for the Treatment of Psoriasis
Authors: Pandey Kalpana , Nimisha
Published: February 2020

Background:

Psoriasis is a chronic autoimmune disorder of the skin which is characterized by the reoccurring episodes of inflammatory lesions with a worldwide occurrence of around 2-5%. Psoriasis can be categorized as mild, moderate and severe conditions. In mild psoriasis, there is the formation of rashes, and when it becomes moderate, the skin turns scaly. In severe conditions, the red patches can be seen on the skin surface and the skin becomes itchy. The different treatment approaches include phototherapy, topical, oral and other systemic drug deliveries. Dermal treatment is now highly endorsed in topical indications for psoriatic patients, due to its higher penetration which can be achieved using pharmaceutical carriers.

Objective:

Though various conventional formulations are there, therapeutic benefits can be provided only to a limited extent. The objective of this review was to highlight newer biocompatible and biodegradable materials like phospholipids, and forefront drug delivery methods like liposomes, microemulsions, nanoemulsions, niosomes, ethosomes, etc. which has increased the possibility to improve the efficacy and safety of the topical products. Apart from this, many medicinal plants are available in nature that are used for treating skin diseases like psoriasis.

Conclusion:

The new trends in nanotechnology are marked by subsequent changes in the pharmaceutical research field. To safeguard the research works in the research field, various patents have been introduced, such as Glaxo Smith Kline (GSK 2981278) – RORγ antagonist, etc. The causes, pathophysiology and the herbal plants that are used in treating the disease are also discussed.
miR-18a-3p Encourages Apoptosis of Chondrocyte in Osteoarthritis via HOXA1 Pathway
Authors: Ding Baiyang , Xu Shujuan , Sun Xiumin , Gao Jianming , Nie Wenlei , Xu Hongguang
Published: February 2020

Background:

Osteoarthritis is a disorder of joints featuring inflammation and degeneration
of articular cartilage. Recently, miRs have been found to be associated in the regulation of chondrocytes
and their apoptosis. miR-18a-3p has been found to be associated in the pathogenesis of rheumatoid
arthritis, however, its role in articular cartilage tissues remains unclear.

Methods:

C57BL/6 strain of mice and human cartilage tissue were used for the study. Histological
analysis was done on isolated cartilage samples followed by TUNEL assay and immunohistochemical
analysis. The chondrocytes were isolated from mouse and human cartilage tissues, RNA was isolated
and subjected for qRT-PCR analysis. The chondrocytes were transfected with miR-18a-3p agomir,
antagomir and siHOXA-1. Luciferase assay was done in 293T cells. Flow cytometry analysis was
done and western blot analysis for studying the expression of proteins.

Results:

The expression of miR-18a-3p was upregulated in chondrocytes after exposing them to interlukin-
1β (IL-1β) in vitro. The transfection of miR-18a-3p antagomir halted the IL-1β mediated apoptosis.
The luciferase assay suggested that miR-18a-3p targets the 3’UTR region of HOXA1 gene thus
blocking its expression. The treatment of HOXA1 siRNA demonstrated the rescuing effect of miR-
18a-3p antagomir on the apoptosis of chondrocytes. Treatment of miR-18a-3p antagomir attenuated
the surface of cartilage in osteoarthritis mice and the agomir worsened it. TUNEL assay suggested
decreased apoptosis and over-expression of HOAX1 in osteoarthritis mice post miR-18a-3p knockdown.

Conclusion:

The findings confirmed the involvement of miR-18a-3p/HOXA1 pathway as a potential
mechanism in the regulation of Osteoarthritis.
Role of MicroRNA Genes miR-1000and miR-375in Forming Olfactory Conditional Memory in Drosophila melanogaster
Authors: Rahman Sadniman , Modak Chaity , Akter Mousumi , Alam Mohammad Shamimul
Published: February 2020

Background:

Learning and memory are basic aspects of neurogenetics as most of the neurological
disorders start with dementia or memory loss. Several genes associated with memory formation
have been discovered. MicroRNA genes, miR-1000 and miR-375, were reported to be associated
with neural integration and glucose homeostasis in some insects and vertebrates. However, the
neuronal function of these genes is yet to be established in D. melanogaster.

Objective:

The possible role of miR-1000 and miR-375 in learning and memory formation in this fly
has been explored in the present study.

Methods:

Both types of appetitive and aversive olfactory conditional learning were tested in the miR-
1000 and miR-375 knockout (KO) strains and compared with the wild one. Five days old third instar
larvae were trained by allowing them to be associated with an odor with reward (fructose) or punishment
(salt). Then, the larvae were tested to calculate their preferences to the odor they were
trained with. Learning Index (LI) values and larval locomotion speed were calculated for all strains.

Results:

Knockout strain of miR-1000 showed significant deficiency in both appetitive and aversive
memory formation whereas miR-375 KO strain showed a significantly lower response only in appetitive
one.

Conclusion:

The results of the present study indicate an important role of miR-1000 and miR-375
genes in forming short-term memory in D. melanogaster.
Ion-exchange Resins and Polypeptide Supported Catalysts: A Critical Review
Authors: Biswas Kinkar , Ghosh Sujit , Basu Basudeb
Published: February 2020

Heterogeneous catalysis represents one of the important areas in the field of organic synthesis.
Major developments have been emerged during last few decades and polymer-supported catalysts
have been employed successfully in various catalytic organic transformations. Ion-exchange resins
and polypeptides are two important examples of such heterogeneous polymer-supported catalysts
among others because of their easy accessibility, stability, recoverability and reusability. Cross-linked
ion-exchange resins and polypeptides are highly insoluble, which make them better choice in terms of
their easy separation from the reaction mixture and subsequent recyclability. The present review article
provides an overview of different types of ion exchange resins as polymer-supported catalysts such
as amberlite resin, polystyrene resin, polyionic gel-based systems, ion-exchange resins and prolineimmobilized
species, PEG-bound poly (amino acid), amino acid anchored with Merrifild resin, amphiphilic
block polypeptides etc. Their preparation, characterizations and catalytic applications in diverse
organic transformations have been presented with critical analysis on their stability, mechanistic
overview and suitability etc.
Pengaruh etika kerja Islam dan komitmen organisasi terhadap kinerja guru
Authors: Ali Khodijah Muhammad
Published: February 2020

Tujuan dari penelitian ini adalah untuk membuktikan adanya pengaruh etika kerja Islam dan komitmen organisasi terhadap kinerja guru SMP Islam Terpadu (SMPIT) di kota Tasikmalaya. Metode penelitian yang digunakan adalah metode survei, dengan menggunakan pendekatan kuantitatif. Penelitian ini dilakukan di 9 SMP Islam Terpadu di Kota Tasikmalaya, dengan populasi 114 orang guru dan sampel 89 orang guru. Teknik pengambilan sampel yang digunakan adalah teknik proportional random sampling, dengan menggunakan kuesioner sebagai pengumpulan data. Analisis data penelitian yang digunakan adalah path analysis. Hasil penelitian menunjukkan bahwa: pertama, terdapat pengaruh positif secara langsung dalam etika kerja Islam terhadap kinerja. Kedua, terdapat pengaruh positif secara langsung dalam komitmen organisasi terhadap kinerja. Ketiga, terdapat pengaruh positif secara langsung dalam etika kerja Islam terhadap komitmen organisasi. Berdasarkan hasil penelitian dapat disimpulkan bahwa untuk meningkatkan kinerja guru SMPIT di Kota Tasikmalaya, upaya yang dapat dilakukan adalah dengan meningkatkan kesadaran akan etika kerja Islam dan komitmen organisasi.Kata kunci: etika kerja Islam, komitmen organisasi, dan kinerja Effect of Islamic word ethic and organizational commitment to teachers performanceAbstractThe purpose of this research was to examine the influence of Islamic work ethic and organizational commitment to the job performance of Integrated Islamic Junior High School (SMPIT) teachers in the city of Tasikmalaya. The research method used survey methods, using a quantitive approach. This research was conducted in 9 Integrated Islamic Junior High School in Tasikmalaya City, with a population of 114 teachers and a sample of 89 teachers. The sampling technique used a proportional random sampling technique, using a questionnaire as data collection. Research data analysis used path analysis. The result of the study show that: first, there is a positive direct influence of Islamic work ethic on job performance. Second, there is a positive direct influence of organizational commitment on job performance. Third, there is a positive direct influence of Islamic work ethic on organizational commitment. Based on the result of the study, it can be concluded that: to improve the job performance of SMPIT teachers in Tasikmalaya City, it can be done by increasing awareness of Islamic work ethic and organizational commitment.Keywords: Islamic work ethic, organizational commitment, job performance
Efektivitas pembelajaran IPS melalui implementasi metode jigsaw ditinjau dari aktivitas dan hasil belajar
Authors: Suryani Elis , Aman Aman
Published: February 2020

Penelitian ini bertujuan untuk mengetahui ada tidaknya perbedaan aktivitas dan hasil belajar IPS siswa menggunakan metode Jigsaw dibandingkan menggunakan metode Ceramah di Kelas VIII SMP Negeri 1 Masaran Sragen, serta keefektifan metode Jigsaw terhadap aktivitas dan belajar dalam pembelajaran IPS siswa kelas VIII SMP Negeri 1 Masaran Sragen. Penelitian ini merupakan True Experimental Design dengan desain Pretest-Posttest Control Group Design. Analisis data menggunakan analisis statistik independent sample t-test dengan bantuan program SPSS 16.00 for Windows Hasil penelitian menunjukkan adanya perbedaan aktivitas dan hasil belajar dalam pembelajaran IPS menggunakan metode Jigsaw dibandingkan menggunakan metode Ceramah di Kelas VIII SMP Negeri 1 Masaran Sragen. Hal ini ditunjukkan dari hasil uji t pada aktivitas dan hasil belajar. Besar ukuran efek metode Jigsaw terhadap aktivitas dan hasil belajar memberikan efek sedang. Hal ini berarti, metode Jigsaw efektif terhadap aktivitas dan hasil belajar dalam pembelajaran IPS siswa kelas VIII SMP Negeri 1 Masaran Sragen. AbstractThis study aimed to find out the differences in the comparison of using IPS learning activity and output using Jigsaw and lecturing method at SMP Negeri 1 Masaran Sragen Grade VIII and the effectiveness of Jigsaw method on students’ learning activity and output in IPS learning at SMP Negeri 1 Masaran Sragen Grade VIII. This study is true experimental with Pretest-Posttest Control Group Design. The data analysis technique used statistic analysis of independent sample t-test towards the gain score in assistance with SPSS 16.00 for Windows program. The study showed the differences in the learning activity and learning output in using the Jigsaw method in comparison with lecturing method at SMP Negeri 1 Masaran Sragen. It can be seen from the result of t-test on learning activity and output. The Jigsaw method effect on learning activity and output give a medium effect. This means, the Jigsaw method was effective on students’ learning activity and output in IPS learning at SMP Negeri 1 Masaran Sragen Grade VIII.
Pengaruh gaya kepemimpinan, budaya sekolah dan motivasi terhadap kinerja guru SMP swasta
Authors: Candra Vivi , Sudirman Acai , Silaban Pasaman
Published: February 2020

Tujuan dari penelitian ini untuk menguji dampak gaya kepemimpinan kepala sekolah, budaya sekolah, dan motivasi terhadap kinerja guru di SMP Swasta Sultan Agung Pematangsiantar. Jumlah anggota populasi adalah 31 orang. Oleh karena itu, penelitian ini menggunakan metode deskriptif kuantitatif dengan menggunakan kuesioner atau sensus. Instrumen penelitian dalam penelitian ini adalah kuesioner yang dibagikan secara langsung kepada responden untuk mencari data yang berhubungan dengan penelitian ini. Metode analisis data yang digunakan adalah analisis kuantitatif dan analisis kualitatif. Hasil penelitian dan hasil pengumpulan data menunjukkan bahwa secara parsial, variabel gaya kepemimpinan kepala sekolah berpengaruh signifikan terhadap kinerja guru, variabel budaya sekolah berpengaruh signifikan terhadap kinerja guru, dan variabel motivasi berpengaruh signifikan terhadap kinerja guru. Temuan empiris tersebut mengindikasikan bahwa untuk meningkatkan kinerja guru, maka SMP Swasta Sultan Agung Pematangsiantar perlu memperhatikan faktor-faktor yang mempengaruhi kinerja guru, seperti kepemimpinan kepala sekolah, budaya sekolah, dan motivasi.  Dengan mengetahui pengaruh hubungan tersebut dapat dijadikan sebagai parameter untuk merancang strategi dimasa yang akan datang guna meningkatkan kinerja guru. AbstractThis study aims to examine the impact of principals' leadership style, school culture, and motivation on teacher performance at Sultan Agung Pematangsiantar Middle School. The number of members of the population is 31 people. Therefore, this study uses a quantitative descriptive method using a questionnaire or census. The research instrument in this study is a questionnaire that was distributed directly to respondents to look for data related to this study. The data analysis method used is the quantitative analysis and qualitative analysis. The results of the study and the results of data collection showed that partially, the principal leadership style variable had a significant effect on teacher performance, the school culture variable had a significant effect on teacher performance, and the motivation variable had a significant effect on teacher performance. The empirical findings indicate that to improve teacher performance, Sultan Agung Pematangsiantar Middle School needs to pay attention to the factors that influence teacher performance, such as principals' leadership, school culture, and motivation. Because by knowing the effect of the relationship can be used as a parameter to design a strategy in the future to improve teacher performance.
Analisis pemanfaatan jurnal elektronik oleh mahasiswa menggunakan Technology Acceptance Model (TAM)
Authors: Nurdiansyah Edwin , Dhita Aulia Novemy , Pratita Dewi
Published: February 2020

Penelitian ini bertujuan untuk mendeskripsikan pemanfaatan jurnal elektronik yang terdapat pada program studi PPKn, program studi Pendidikan Sejarah dan program studi Pendidikan Ekonomi di Universtas Sriwijaya menggunakan technology acceptance model (TAM). Sampel penelitian yaitu mahasiswa semester 3, 5, dan 7 pada jurusan Pendidikan Ilmu Pengetahuan Sosial (PIPS). Metodologi penelitian menggunakan metode kuantitatif dengan menggunakan kuesioner sebagai alat pengumpul data, kemudian data di analisis secara deskriptif dan analisis statistik inferensial. Hasil uji hipotesis menunjukan tidak ada pengaruh positif dan signifikan instrument perceived easy to use terhadap attitude toward using pada Jurnal Bhineka Tunggal Ika serta Jurnal Criksetra. Selanjutnya hasil uji hipotesis juga menunjukan ada pengaruh positif dan signifikan perceived usefulness terhadap attitude toward using pada Jurnal Bhineka Tunggal Ika serta Jurnal Criksetra. Untuk Jurnal Profit pada program studi Pendidikan Ekonomi tidak memenuhi kriteria untuk dilanjutkan penelitian karena hanya lima mahasiswa yang mengetahui tentang jurnal tersebut. AbstractThis study aims to describe the utilization of electronic journals contained in the civic education study program, historical education study programs and economic education study programs using technology acceptance models (TAM). The sample of the study is the semester 3, 5, and 7 students in the Educational of Social Science department. The research methodology uses quantitative methods with a questionnaire as a data collection tool, then the data is analyzed descriptively and inferential statistical analysis. The results of the hypothesis test show that there is no positive effect and that the instrument is perceived to be easy to use towards the attitude toward using the Journal of Unity in Diversity and the Criksetra Journal. Furthermore, the results of the hypothesis test also showed that there was a positive and significant perceived usefulness effect on the attitude toward using the Journal of Unity in Diversity and the Criksetra Journal. For the Profit Journal in the Economic Education study program does not meet the criteria for continued research because only five students know about the journal.
A Study of Korean Hearing Aid Satisfaction Survey Based on MarkeTrak VIII
Authors: Sim Sangik , Lee Junghak , Kim Jinsook
Published: February 2020

Purpose: The aim of this study was to survey the satisfaction of hearing aid users in Korea. The questionnaire was designed to find out not only the satisfaction of wearing hearing aid but also the various viewpoints about the hearing aid itself of its wearers.Methods: A total of 118 subjects including 72 males and 46 females completed the survey from 28 hearing aids centers. The questionnaire was divided into two parts. The first part contained the audiological information reported by the experts and the other part included about the information of hearing aid performance, listening environments and related services reported by the hearing aid users.Results: Overall satisfaction rate of hearing aid was 64.4%. About 84% of the subjects answered that the hearing aid made their quality of life improved. The most satisfied function of the hearing aid was ‘overall comfort,’ the most satisfied sound quality was ‘improved hearing ability,’ the most satisfied listening environments was ‘one-to-one conversation,’ and the most satisfied service quality was ‘kindness of the staffs.’ The most important listening situation they thought was ‘communication with cell phone.’ The proportion of using customized hearing aid was 77.9%, bilateral fitting rate was 62.4% and average purchasing price was 1,820,000 won per a unit.Conclusion: The overall hearing aid satisfaction rate (64.4%) was lower than USA (81%) and Germany (76%) but higher than Japan (38%). In Korea, the comprehensive study for the hearing aid market, specific satisfaction viewpoints of the hearing aid wearers and the status of non-wearers who have hearing loss should be needed for improving the user’s hearing aid satisfaction rate in the future.
The Pathophysiology of Tinnitus: Involvement of the Somatosensory, Brain, and Limbic Systems
Authors: Lee Yuri , Kim Taehwa , Lee Kieun , Jeon Seungik , Jo Sungmin , Jin In-Ki
Published: February 2020

This study reviewed the pathophysiology of tinnitus. Tinnitus is a symptom that a subject perceives sound regardless of external stimuli. Tinnitus sufferers have reported varying sound types, loudness, and duration of tinnitus. Also, the pathophysiology of tinnitus is also reported to be varied. We searched a web database and found 2,545 articles related to tinnitus. The selection criteria for articles to be reviewed was the year of publication, research category, participant characteristic, publication type, and area of study. Thirty-three studies on the pathophysiology of tinnitus were finally selected and reviewed. Tinnitus pathophysiology was reviewed in relation to the somatosensory, brain, and limbic systems. Fourteen sub-regions were identified to be associated with tinnitus. The data on each sub-region was also reviewed, including its primary role and the tinnitus trigger mechanism. The results of this study can be used as baseline data for studies attempting to understand the mechanism of tinnitus and develop intervention methods.
Aircraft Noise of Airport Community in Korea
Authors: Oh Soo Hee , Lee Kyoungwon
Published: February 2020

Aircraft noise is one of the serious environmental noises with the increased use of flight traffic. The purpose of this study is to understand aircraft noise levels of airport communities in Korea using baseline data for audiologic management. Aircraft noise levels were retrieved from the National Noise Information System every month between 2004 and 2018. We reviewed aircraft noise levels obtained from total of 111 airport communities across 14 airports. In order to understand aircraft noise levels of civil and military airports, the aircraft noise levels measured in civil and military airport communities compared with the noise levels from civil airport communities. The data showed average 71-73 weight equivalent continuous perceived noise level (WECPNL) for fifteen years across airport cities and the average noise levels did not increase over time between 2004 and 2018 years. The civil and military airports showed about 12 WECPNLs of increased noise levels compared to the civil airports. The most civil and military airport communities, including Gwangju, Gunsan, Daegu, Wonju, and Cheongju generated the maximum noise levels and ranked as the highest airport for aircraft noise levels. Although aircraft noise levels in airport communities were similar over the past decade, civil and military airports generated increased noised levels compared to civil airports due to jet plane noises and other military-related noises. Careful consideration is necessary to implement noise reduction policy for civil and military airport communities. Ongoing noise control, hearing monitoring, education, and relevant policies are required to improve the quality of life in the airport community residences.
General Practitioners’ Perceptions of Whether Teleconsultations Reduce the Number of Face-to-face Visits in the Catalan Public Primary Care System: Retrospective Cross-Sectional Study
Authors: López Seguí Francesc , Vidal-Alaball Josep , Sagarra Castro Marta , García-Altés Anna , García Cuyàs Francesc
Published: February 2020

Background

eConsulta is a teleconsultation service involving general practitioners (GPs) and patients. It is part of the information system belonging to Catalonia’s primary care service. It has been in operation since the end of 2015 in conjunction with face-to-face consultations with Primary Care Teams as one of the services offered in the patient’s Personal Health Folder.

Objective

This study aimed to assess the ability of using eConsulta to reduce the number of face-to-face visits to Primary Care Teams.

Methods

Using 13 categories proposed by the researchers, 18 GPs from the Central Catalonia Health Region retrospectively classified 2268 cases managed with eConsulta and indicated whether, in their opinion, the teleconsultations reduced the number of face-to-face visits.

Results

There was broad consensus among the GPs that eConsulta has the potential to resolve patient queries for every type of consultation. eConsulta avoided the need for a face-to-face visit in 87.9% of cases. In addition, the GPs reported that the ease of access increased the demand for health care support in 27.7% of cases; otherwise, the patient would not have initiated the queries. Therefore, based on the equation (88% x [1-28%]), eConsulta could replace 63%-88% of conventional appointments. The most frequent uses of the teleconsultation service were for management of test results (35.2%), medical enquiries (16.0%), and the management of repeat prescriptions (12.2%). On average, the teleconsultations consisted of a mean 1.57 messages (SD 0.54 messages); 45.9% (1040/2268) of the teleconsultations consisted of 1 message, and the majority of the remaining teleconsultations consisted of 2-5 interactions. The patient initiated 60.0% (1361/2268) of the teleconsultations.

Conclusions

Based on the GPs’ perceptions, eConsulta could replace 63%-88% of conventional appointments. Therefore, asynchronous teleconsultations between practitioners and patients in primary care could avoid interactions that have limited added clinical value.
A Mobile Phone–Based Sexual and Reproductive Health Intervention for Female Sex Workers in Kenya: Development and Qualitative Study
Authors: Ampt Frances H , L'Engle Kelly , Lim Megan S C , Plourde Kate F , Mangone Emily , Mukanya Collins Mudogo , Gichangi Peter , Manguro Griffins , Hellard Margaret , Stoové Mark , Chersich Matthew F , Jaoko Walter , Agius Paul A , Temmerman Marleen , Wangari Winnie , Luchters Stanley
Published: February 2020

Background

Female sex workers (FSWs) have high rates of both unintended pregnancy and HIV, but few health promotion interventions address their contraceptive needs or other sexual and reproductive health and rights (SRHR) concerns. A broader approach integrates contraceptive promotion with HIV and sexually transmitted infection (STI) prevention and management, alcohol awareness, gender-based violence and rights, and health care utilization. The Women’s Health Intervention using SMS for Preventing Pregnancy (WHISPER) mobile phone intervention uses a participatory development approach and behavior change theory to address these high-priority concerns of FSWs in Mombasa, Kenya.

Objective

This paper aimed to (1) describe the process of development of the WHISPER intervention, its theoretical framework, key content domains and strategies and (2) explore workshop participants’ responses to the proposed intervention, particularly with regard to message content, behavior change constructs, and feasibility and acceptability.

Methods

The research team worked closely with FSWs in two phases of intervention development. First, we drafted content for three different types of messages based on a review of the literature and behavior change theories. Second, we piloted the intervention by conducting six workshops with 42 FSWs to test and refine message content and 12 interviews to assess the technical performance of the intervention. Workshop data were thematically analyzed using a mixed deductive and inductive approach.

Results

The intervention framework specified six SRHR domains that were viewed as highly relevant by FSWs. Reactions to intervention content revealed that social cognitive strategies to improve knowledge, outcome expectations, skills, and self-efficacy resonated well with workshop participants. Participants found the content empowering, and most said they would share the messages with others. The refined intervention was a 12-month SMS program consisting of informational and motivational messages, role model stories portraying behavior change among FSWs, and on-demand contraceptive information.

Conclusions

Our results highlight the need for health promotion interventions that incorporate broader components of SRHR, not only HIV prevention. Using a theory-based, participatory approach, we developed a digital health intervention that reflects the complex reality of FSWs’ lives and provides a feasible, acceptable approach for addressing SRHR concerns and needs. FSWs may benefit from health promotion interventions that provide relevant, actionable, and engaging content to support behavior change.
Serious Game on a Smartphone for Adolescents Undergoing Hemodialysis: Development and Evaluation (Preprint)
Authors: Santana Cristina Célia De Almeida Pereira , Freitas Ana Tereza Vaz De Souza , Oliveira Barreto Gilson , Sousa De Avelar Igor , Mazaro-Costa Renata , Bueno Gina Nolêto , Ribeiro Diuly Caroline , Damasceno Silva Gabriela , Naghettini Alessandra Vitorino
Published: February 2020

BACKGROUND

Adolescents with chronic kidney disease have a hard time adhering to hemodialysis as a therapy, indicating a need to establish new alternatives for motivation and adherence to treatment.

OBJECTIVE

The objective of this study was to develop and evaluate a serious game to stimulate and motivate adolescents undergoing hemodialysis.

METHODS

We describe the technological production followed by a qualitative analysis. We invited 8 adolescents undergoing hemodialysis in the city Goiânia, located in the midwest of Brazil, to participate. The final convenience sample included 7 (87.5% of the target population) adolescents. The process was conducted in 3 phases: creation of a serious game, evaluation of its use, and observation of its motivating effect on behavioral modification with a focus on acquiring the necessary competence for self-care.

RESULTS

An app (Bim) in the modality of a serious game was developed to be used during hemodialysis; the player was encouraged to take care of a character with daily actions during his or her treatment. The game was made available to adolescents aged 10-14 years. Mobile devices were offered during the hemodialysis treatment for a period of 30-40 minutes, 3 times a week for 60 days. The usage definitions of the game were freely chosen by the participants. The qualitative evaluation of the use of the Bim app showed that it encompasses scenarios and activities that enable the exercise of daily actions for the treatment of patients. The behavioral evaluation showed that the Bim app worked as a motivating stimulus for behavioral adherence to hemodialysis requirements.

CONCLUSIONS

The easy-to-access app interface showed good operability for its users. The description of the character and proposed activities contributed to motivation and ability to cope with hemodialysis care.