bluuebunny/crossref_metadata_2025 huggingface dataset:
Adaptive Behavior: Teachers and Parents Disagree
Authors: Mealor David J. , Richmond Bert O.
Published: January 2022

This article explores the concept of adaptive behavior. It notes some of the problems in measuring adaptive behavior and focuses on the possible bias that occurs in relying on informed sources to report the child's adaptive behavior. Moderately or severely retarded children (30 Black and 30 White) were selected randomly from schools serving them. A teacher and parent were asked to complete two adaptive behavior scales on each child. Parents and teachers did not always agree on the child's level of adaptive behavior.
Mechanical properties of carbon fibre reinforced composites modified with star-shaped butyl methacrylate
Authors: Pinto Rochele , Monastyreckis Gediminas , Aboelanin Hamza Mahmoud , Spacek Vladimir , Zeleniakiene Daiva
Published: January 2022

This article presents the possibility of strength improvement and energy absorption of carbon fibre reinforced polymer composites by matrix modification. In this study, the mechanical properties of bisphenol-A epoxy matrix and carbon fibre reinforced polymer composites were modified with four different wt.% of star-shaped polymer n-butyl methacrylate (P n-BMA) block glycidyl methacrylate (PGMA). The tensile strength of the epoxy with 1 wt.% star-shaped polymer showed 128% increase in comparison to unmodified epoxy samples. Two different wt.% were then used for the modification of carbon fibre-reinforced polymer composite samples. Tensile tests and low-velocity impact tests were conducted for characterising modified samples. Tensile test results performed showed a slight improvement in the tensile strength and modulus of the composite. Low-velocity impact tests showed that addition of 1 wt.% star-shaped polymer additives increase composite energy absorption by 53.85%, compared to pure epoxy composite specimens. Scanning electron microscopy (SEM) analysis of post-impact specimens displays fracture modes and bonding between the matrix and fibre in the composites. These results demonstrate the potential of a novel star-shaped polymer as an additive material for automotive composite parts, where energy absorption is significant.
Views of Community Corrections Supervision and Their Predictors: An Officer and Offender Comparison
Authors: Jiang Shanhe , Zhang Dawei , Lambert Eric G.
Published: January 2022

Appropriate supervision strategies are the backbone of community corrections. The success of community supervision is dependent upon the attitudes of both officers and offenders. Despite this, research on offenders’ attitudes toward community corrections supervision is surprisingly very limited. The current study investigated attitudes of officers and offenders toward and predictors of four different community supervision strategies based on data collected in Hubei, China, in 2103 and 2016. The study found that among demographics, community variables, and value factor, the mutual trust value factor was the most important predictor of community supervision strategies by both officers and offenders. Additional findings and policy implications are discussed.
Are Immigrants Scapegoats? The Reciprocal Relationships Between Subjective Well-Being, Political Distrust, and Anti-immigrant Attitudes in Young Adulthood
Authors: Korol Liliia , Fietzer Alexander W. , Bevelander Pieter , Pasichnyk Ihor
Published: January 2022

This study examined the impact of native youth’s subjective well-being on exclusionary attitudes toward immigrants, seeking to understand the relationship between subjective well-being, political distrust, and anti-immigrant attitudes over time. Using longitudinal data, we followed three cohorts of native young adults ( N = 1352; Mage = 22.72, SD = 3.1) in Sweden over a period of 2 years. The results showed that subjective well-being did not predict an increase in anti-immigrant attitudes among native youth, but anti-immigrant attitudes had a significant impact on subjective well-being. The data also found bidirectional and mutually reinforcing relationships between subjective well-being and political distrust, and between political distrust and anti-immigrant attitudes. These results highlight that improving young adults’ subjective well-being represents an important basis for preventing the development of political distrust, which in turn could reduce native youth’s susceptibility to adopt hostile attitudes toward immigrants.
Association of Pediatric Hearing Quality and Sports Participation: A Population‐Based Study
Authors: Kozin Elliott D. , Knoll Renata M. , Bhattacharyya Neil
Published: January 2022

Sports‐related injuries, such as concussion, during childhood may result in considerable morbidity, including a range of negative developmental consequences. Auditory dysfunction is generally recognized to be a possible sequela of sports‐related concussion; however, few epidemiologic studies have quantified the association between hearing quality and sports‐related activity in the pediatric population. The National Health and Nutrition Examination Survey for the 2015‐2016 cycle was utilized to determine the association of sports activities and hearing quality. Subjective abnormal hearing quality was more frequent among children who played football than those that did not (36.5% vs 26.8%; odds ratio, 1.56 [95% CI, 1.23‐2.00]; P =. 001). Other sports, such as basketball and soccer, did not have this association with hearing quality (P =. 496 and P =. 852, respectively). Our findings suggest a notable association between practice of a potentially high concussion sport and hearing quality. Children practicing football are 1.56 times more likely to report abnormal hearing quality.

Level of Evidence: 4.
Experiences of stressful situations and mindfulness training for persons with visual impairment
Authors: Lyngroth May Britt Frøysa , Gammelsæter Frøydis
Published: January 2022

The aim of this study was to explore what persons with visual impairment (VI) experienced as stressful in their daily lives and their experiences with using mindfulness training (MT) to cope with stressful situations. In order to explore this we conducted semi-structured interviews with six persons with VI after finishing an 8-week MT course. Systematic text condensation was used to analyze the interviews. This qualitative study found that the participants described three main areas of stress: (1) lack of access to information, (2) social expectations, and (3) navigating the body through one’s surroundings. The participants’ experiences with using MT to cope with stressful situations resulted in emotion-based and problem-based strategies: (1) breathing anchor, (2) awareness of and reflection upon thoughts and feelings, (3) most things are doable, (4) tackling the situation in a new way, and (5) haste makes waste. Our respondents described using MT for coping with stressful situations in all the three main areas of stress. Based upon this study we propose that there is good reason to offer MT as stress management for persons with VI, but further study is required to confirm the health-promoting benefits of MT for this group.
Using Sequence Analysis to Identify Conversational Motifs in Supportive Interactions
Authors: Solomon Denise Haunani , Jones Susanne , Brinberg Miriam , Bodie Graham D. , Ram Nilam
Published: January 2022

This study demonstrates how sequence analysis, which is a method for identifying common patterns in categorical time series data, illuminates the nonlinear dynamics of dyadic conversations by describing chains of behavior that shift categorically, rather than incrementally. When applied to interpersonal interactions, sequence analysis supports the identification of conversational motifs, which can be used to test hypotheses linking patterns of interaction to conversational antecedents or outcomes. As an illustrative example, this study evaluated 285 conversations involving stranger, friend, and dating dyads in which one partner, the discloser, communicated about a source of stress to a partner in the role of listener. Using sequence analysis, we identified three five-turn supportive conversational motifs that had also emerged in a previous study of stranger dyads: discloser problem description, discloser problem processing, and listener-focused dialogue. We also observed a new, fourth motif: listener-focused, discloser questioning. Tests of hypotheses linking the prevalence and timing of particular motifs to the problem discloser’s emotional improvement and perceptions of support quality, as moderated by the discloser’s pre-interaction stress, offered a partial replication of previous findings. The discussion highlights the value of using sequence analysis to illuminate dynamic patterns in dyadic interactions.
Notes on policing, racism and the Covid-19 pandemic in the UK
Authors: Harris Scarlet , Joseph-Salisbury Remi , Williams Patrick , White Lisa
Published: January 2022

This commentary excerpts from the research report ‘A threat to public safety: policing, racism and the Covid-19 pandemic’, carried out by the Centre on the Dynamics of Ethnicity (CoDE) and published by the Institute of Race Relations in September 2021. One of the only pieces of research based on the experiences of the policed and their testimonies, the report suggests that policing during the Covid-19 pandemic undermines public health measures whilst disproportionately targeting Black and Minority Ethnic communities in the UK. The authors raise concerns about the policing of the pandemic and show that racially minoritised communities have been most harshly affected – being more likely to be stopped by the police, threatened or subject to police violence and falsely accused of rule-breaking and wrong-doing. The report argues that lockdown conditions, new police powers, and histories of institutionally racist policing have combined to pose a threat to already over-policed communities and the most marginalised and vulnerable sections of society.
The State of the Do-Not-Resuscitate Order in a Pediatric Intensive Care Unit in the Middle East: A Retrospective Study
Authors: Sabouneh R. , Lakissian Z. , Hilal N. , Sharara-Chami R.
Published: January 2022

Objectives: The Do-Not-Resuscitate (DNR) order is part of most hospitals’ policies on the process of making and communicating decisions about a patient's resuscitation status. Yet it has not become a part of our society's ritual of dying in the Middle East especially among children. Given the diversity of pediatric patients, the DNR order continues to represent a challenge to all parties involved in the care of children including the medical team and the family. Methods: This was a retrospective review of the medical charts of patients who had died in the pediatric intensive care unit (PICU) of a tertiary academic institution in Beirut, Lebanon within the period of January 2012 and December 2017. Results: Eighty-two charts were extracted, 79 were included in the analysis. Three were excluded as one patient had died in the Emergency Department (ED) and 2 charts were incomplete. Most patients were male, Lebanese, and from Muslim families. These patients clinically presented with primary cardiac and oncological diseases or were admitted from the ED with respiratory distress or from the operating room for post-operative management. The primary cause of death was multiorgan failure and cardiac arrest. Only 34% of families had agreed to a DNR order prior to death and 10% suggested “soft” resuscitation. Most discussions were held in the presence of the parents, the PICU team and the patient's primary physician. Conclusions: The DNR order presents one of the most difficult challenges for all care providers involved, especially within a culturally conservative setting such as Lebanon. As the numbers suggest, it is difficult for parents to reach the decision to completely withhold resuscitative measures for pediatric patients, instead opting for “soft” resuscitations like administering epinephrine without chest compressions.
Effect of the inlet gas volume fraction on the turbulent dissipation characteristics in the multiphase pump
Authors: Shi Guangtai , Dan Yue , Xiao Yexiang , Shu Zekui , Liu Xiaobing
Published: January 2022

The internal flow of the multiphase pump is complicated owing to its specific structure. To reveal the effect of the inlet gas volume fraction (IGVF) on the turbulent dissipation characteristics, the method of combining numerical simulation based on k-ε turbulence model with experiment was adopted, and the turbulent dissipation of the multiphase pump was quantitatively and qualitatively analyzed in both the pure water and gas-liquid two phases condition. Results showed the vortexes were primarily distributed in the diffusers at different inlet gas volume fractions (IGVFs), near the middle of the first diffuser and the outlet of the next diffuser. At the same time, the larger value of the turbulent dissipation than that in the impellers was concentrated in the inlet and outlet of the impellers and diffusers. In addition, the effect of IGVFs on the turbulent dissipation increased gradually from the hub to the shroud at the inlet section of the first impeller. Moreover, the turbulent dissipation became increasingly unsymmetrical from the hub to the shroud at the outlet section of the first impeller.
Data-driven model-free adaptive fractional-order sliding mode control for the SMA actuator with prescribed performance
Authors: Liu Hongshuai , Hao Lina , Liu Mingfang , Zhao Zhirui
Published: January 2022

In this paper, a novel data-driven model-free adaptive fractional-order sliding mode controller with prescribed performance is proposed for the shape memory alloy (SMA) actuator. Due to the strong asymmetric saturated hysteresis nonlinear characteristics of the SMA actuators, it is not easy to establish an accurate model and develop an effective controller. Therefore, we present a controller without using the model of the SMA actuators. In other words, the proposed controller depends merely on the input/output (I/O) data of the SMA actuators. To obtain the reasonable compensation for hysteresis, enhance the noise robustness of the controller, and reduce the chattering, a fractional-order sliding mode controller with memory characteristics is employed to improve the performance of the controller. In addition, the prescribed performance control (PPC) strategy is introduced in our work to guarantee the tracking errors converge to a sufficiently small boundary and the convergence rate is not less than a predetermined value which are significant and considerable in practical engineering applications of the SMA actuator. Finally, experiments are carried out, and results reveal the effectiveness and success of the proposed controller. Comparisons with the classical Proportional Integral Differential (PID), model-free adaptive control (MFAC), and model-free adaptive sliding mode control (MFAC-SMC) are also performed.
A novel phenomenological model for predicting hysteresis loss of rubber compounds obtained from ultra-large off-the-road tires
Authors: Ma Shaosen , Huang Guangping , Obaia Khaled , Won Moon Soon , Victor Liu Wei
Published: January 2022

The objective of this study was to develop a novel phenomenological model that can predict the hysteresis loss of rubber compounds obtained from ultra-large off-the-road (OTR) tires under typical operating conditions at mine sites. To achieve this, first, cyclic tensile tests were conducted on tire tread compounds to derive the experimental results of hysteresis curves, peak stress, residual strain, and hysteresis loss at 6 strain levels, 8 strain rates, and 14 rubber temperatures. Then, referring to these experimental results, a phenomenological model was developed – the HLSRT model (a hysteresis loss model considering strain levels, strain rates, and rubber temperatures). This HLSRT model was generated based on a novel strain energy function that was modified from the traditional Mooney-Rivlin (MR) function, and the model was used to predict the hysteresis loss of rubber compounds in OTR tires. The prediction results show that the HLSRT model estimated the hysteresis loss of tire tread compounds with average and maximum mean absolute percent errors (MAPEs) of 11.2% and 18.6%, respectively, at strain levels ranging from 10% to 100%, strain rates from 10% to 500% s−1, and rubber temperatures from −30°C to 100°C. These MAPEs were relatively low when compared with previous studies, showing that the HLSRT model has higher prediction accuracy. For the first time, the HLSRT model derived from this study has provided a new approach to predicting the hysteresis loss of OTR tire rubbers to guide the use of OTR tires in truck haulage at mine sites.
Queen’s Gambit Declined: The Gender-Equality Paradox in Chess Participation Across 160 Countries
Authors: Vishkin Allon
Published: January 2022

The gender-equality paradox refers to the puzzling finding that societies with more gender equality demonstrate larger gender differences across a range of phenomena, most notably in the proportion of women who pursue degrees in science, technology, engineering, and math. The present investigation demonstrates across two different measures of gender equality that this paradox extends to chess participation ( N = 803,485 across 160 countries; age range: 3–100 years), specifically that women participate more often in countries with less gender equality. Previous explanations for the paradox fail to account for this finding. Instead, consistent with the notion that gender equality reflects a generational shift, mediation analyses suggest that the gender-equality paradox in chess is driven by the greater participation of younger players in countries with less gender equality. A curvilinear effect of gender equality on the participation of female players was also found, demonstrating that gender differences in chess participation are largest at the highest and lowest ends of the gender-equality spectrum.
Effect of Gamma-irradiation on the Physicochemical, Functional, and Antioxidant Properties of Unpigmented Brown Whole Rice Flour
Authors: Bhat Naseer Ahmad , Wani Idrees Ahmed , Sultan Neelofar
Published: January 2022

Whole grain brown rice, being a rich source of fiber and other bioactive compounds like polyphenols is effective in reducing the risk of chronic diseases including cardiovascular diseases, hypercholesterolemia and Type II diabetes. The study was aimed to evaluate the effect of gamma irradiation on the physicochemical, functional and antioxidant properties of whole grain brown rice flour. The brown rice flour was conditioned to two different moisture contents of 10% and 12% and treated with gamma irradiation doses of 0 kGy (native or control), 2.5 kGy and 5 kGy. Moisture, protein, fat, ash and carbohydrate content of native flour was found as 10 g/100 g, 6.54 g/100 g, 1.54 g/100 g, 1.0 g/100 g, and 81.48 g/100 g, respectively. The hunter color ‘L’, ‘a’, and ‘b’ values of the native brown rice flour sample were found as 81.95, −0.97 and 17.36, respectively and were non-significantly ( p ≥ 0.05) affected by gamma irradiation. Apparent amylose content was observed to decrease significantly ( p ≤ 0.05) from 29.97 to 20.30 g/100 g with the increase in gamma irradiation dose and moisture content. The pasting properties such as peak viscosity, trough viscosity and final viscosity of all the flour samples decreased significantly ( p ≤ 0.05) with the increase in irradiation dose. The functional properties such as water and oil absorption and emulsion capacities were increased while emulsion stability and foaming stability decreased upon irradiation. Irradiation led to an overall increase in the antioxidant activity of rice flours. In general, FTIR spectra revealed a decrease in the absorption intensities of the functional groups. Therefore, it can be concluded that gamma irradiation can be used as a tool to modify the physicochemical properties of rice flours as well as to improve their antioxidant properties.
Practice and performance management strategies of emerging professional musicians in preparation for orchestra auditions
Authors: Kegelaers Jolan , Hoogkamer Lotte , Oudejans Raôul RD
Published: January 2022

Orchestra auditions form a critical career challenge for many aspiring classical musicians. Hence, emerging professional musicians—defined as promising musicians entering the professional circuit without having yet established full-time employment—require effective practice and performance strategies to manage the demands of auditions. The purpose of this collective case study was to gain an in-depth and contextualized understanding of such practice and performance management strategies in relation to mock orchestra auditions. Data were collected using an intensive qualitative approach, combining semi-structured interviews with regular structured monitoring interviews, with eight musicians. Content analysis revealed that participants, on average, engaged in 33 hr of music-related activities per week, during which they adopted self-regulating strategies (i.e., strategic goal setting, structuring practice, monitoring practice, and reflecting on progress) to a varying degree. Furthermore, participants used different performance management strategies to cope with the pressure of auditions (i.e., practicing under pressure, imagery, relaxation, cognitive reframing, routines, attentional control, and substance use). Overall, the data suggest that the emerging musicians possessed several different practice and performance strategies but showed great variation in the use of such strategies and had a preference for long practice hours. Potential implications for music education organizations aiming to prepare students for auditions are discussed.
Network resilience and EU fisheries policy engagement in third countries: Lessons for post-Brexit governance
Authors: Van Der Zwet Arno , Connolly John , Huggins Christopher , McAngus Craig
Published: January 2022

This article examines the ways in which third countries can engage with, and respond to, European Union policy-making processes. A novel analytical framework based on the concept of network resilience which consists of an institutional, political and policy dimension is operationalised to understand third country access to European Union policy-making. Empirically, the article examines the experiences of three non-European Union countries, Iceland, the Faroe Islands and Norway in the context of the European Union’s Common Fisheries Policy. The article concludes by presenting a research agenda based on an in-depth analysis of network resilience and reflects on what the findings mean for future research, particularly within the context of understanding the development of UK–EU post-Brexit relations.
Numerical analysis on fatigue behavior of ultrahigh-performance concrete-Orthotropic steel composite bridge deck
Authors: Huang Yang , Chen Shiming , Gu Ping
Published: January 2022

Ultrahigh-performance concrete-orthotropic steel composite bridge deck is composed of the orthotropic steel deck and a thin ultrahigh-performance concrete (UHPC) overlayer. In the previous fatigue tests, two typical fatigue failure modes were found and identified. As a supplementary test after fatigue tests, air penetration method is capable of providing a reference to the quantitative and non-destructive damage detection of fatigue damage of UHPC. To further the previous study, a detailed numerical investigation is accomplished through complimentary finite element (FE) analysis. Compared with the solid element model, the refined shell-solid element model can better reflect the mechanical behavior. It is illustrated that the vertical stress can be adopted in assessing the fatigue strength of rib-to-diaphragm welded connection in the field test by means of nominal stress method. The combination of various factors would lead to fatigue shear failure of the short headed-studs. The fatigue strength of rib-to-diaphragm welded connection predicted by the hot spot stress method and the consistent nominal stress (CNS) method can basically meet the requirements of FAT90. The consistent nominal stress method can be used as the optimization method of nominal stress of fatigue detail. It is demonstrated that the fatigue life of UHPC can be estimated by S-N curves of ordinary concrete conservatively. The allowable equivalent maximum stress level can be taken as 0.55 for two million cycles of fatigue loading, and 0.52 for five million cycles of fatigue loading.
Fiber element modeling of circular double-skin concrete-filled stainless-carbon steel tubular columns under axial load and bending
Authors: Ahmed Mizan , Liang Qing Quan , Hamoda Ahmed
Published: January 2022

Circular concrete-filled double-skin steel tubular (CFDST) columns with external stainless-steel are high-performance composite columns that have potential applications in civil construction including the construction of offshore structures, bridge piers, and transmission towers. Reflecting the limited research performed on investigating their mechanical performance, this study develops a computationally efficient fiber model to simulate the responses of short and slender beam-columns accounting for the influences of material and geometric nonlinearities. Accurate material laws of stainless steel, carbon steel, and confined concrete are implemented in the mathematical modeling scheme developed. A new solution algorithm based on the Regula-Falsi method is developed to maintain the equilibrium condition. The independent test results of short and slender CFDST beam-column are utilized to validate the accuracy of the theoretical solutions. The influences of various column parameters are studied on the load-axial strain [Formula: see text] curves, load-lateral deflection [Formula: see text] curves, column strength curves, and interaction curves of CFDST columns. Design formulas are suggested for designing short and beam-columns and validated against the numerical results. The computational model is found to be capable of simulating the responses of CFDST short and slender columns reasonably well. Parametric studies show that the consideration of the concrete confinement is important for the accuracy of the prediction of their mechanical responses. Furthermore, high-strength concrete can be utilized to enhance their load-carrying capacity particularly for short and intermediate slender beam-columns. The strengths of CFDST columns computed by the suggested design model are in good agreement with the test and numerical results.
C-reactive protein to albumin ratio provides important long-term prognostic information in patients undergoing endovascular abdominal aortic repair
Authors: Demirci Gökhan , Demir Ali Riza , Uygur Begüm , Bulut Umit , Avci Yalcin , Tükenmez Karakurt Seda , Memiç Sancar Kadriye , Aktemur Tugba , Ersoy Burak , Celik Omer , Erturk Mehmet
Published: January 2022

Background

The prognostic value of C-reactive protein/albumin ratio (CAR) is of import in cardiovascular diseases. Our aim was to evaluate the impact of the CAR in patients with asymptomatic abdominal aortic aneurysm (AAA) undergoing endovascular aneurysm repair (EVAR).

Material and Method

We retrospectively evaluated 127 consecutive patients who underwent technically successful elective EVAR procedure between December 2014 and September 2020. The optimal CAR cut-off value was determined by using receiver operating characteristic (ROC) curve analysis. Based on the cut-off value, we investigated the association of CAR with long-term all-cause mortality.

Results

32 (25.1%) of the patients experienced all-cause mortality during a mean 32.7 ± 21.7 months’ follow-up. In the group with mortality, CAR was significantly higher than in the survivor group (4.63 (2.60–11.88) versus 1.63 (0.72–3.24), p < 0.001). Kaplan–Meier curves showed a higher incidence of all-cause mortality in patients with high CAR compared to patients with low CAR (log-rank test, p < 0.001). Multivariable Cox regression analysis revealed that glucose ≥ 110 mg/dL (HR: 2.740; 95% CI: 1.354–5.542; p = 0.005), creatinine ≥ 0.99 mg/dL (HR: 2.957, 95% CI: 1.282–6.819, p = 0.011) and CAR > 2.05 (HR: 8.190, 95% CI: 1.899–35.320, p = 0.005) were the independent predictors of mortality.

Conclusion

CAR was associated with a significant increase in postoperative long-term mortality in patients who underwent EVAR. Preoperatively calculated CAR can be used as an important prognostic factor.
Don’t blame yourself: Conscious source monitoring modulates feedback control during speech production
Authors: Franken Matthias K , Hartsuiker Robert J , Johansson Petter , Hall Lars , Lind Andreas
Published: January 2022

Sensory feedback plays an important role in speech motor control. One of the main sources of evidence for this is studies in which online auditory feedback is perturbed during ongoing speech. In motor control, it is therefore crucial to distinguish between sensory feedback and externally generated sensory events. This is called source monitoring. Previous altered feedback studies have taken non-conscious source monitoring for granted, as automatic responses to altered sensory feedback imply that the feedback changes are processed as self-caused. However, the role of conscious source monitoring is unclear. The current study investigated whether conscious source monitoring modulates responses to unexpected pitch changes in auditory feedback. During the first block, some participants spontaneously attributed the pitch shifts to themselves (self-blamers) while others attributed them to an external source (other-blamers). Before Block 2, all participants were informed that the pitch shifts were experimentally induced. The self-blamers then showed a reduction in response magnitude in Block 2 compared with Block 1, while the other-blamers did not. This suggests that conscious source monitoring modulates responses to altered auditory feedback, such that consciously ascribing feedback to oneself leads to larger compensation responses. These results can be accounted for within the dominant comparator framework, where conscious source monitoring could modulate the gain on sensory feedback. Alternatively, the results can be naturally explained from an inferential framework, where conscious knowledge may bias the priors in a Bayesian process to determine the most likely source of a sensory event.
Guillain-Barré Syndrome with Rapid Onset and Autonomic Dysfunction Following First Dose of Pfizer-BioNTech COVID-19 Vaccine: A Case Report
Authors: Lanman Tyler Ashford , Wu Connie , Cheung Helen , Goyal Neelam , Greene Maxwell
Published: January 2022

Guillain-Barre syndrome (GBS) is an immune-mediated, often post-infectious illness manifesting as an acute, characteristically monophasic, polyradiculoneuropathy. We present a case of GBS with autonomic involvement following an mRNA-based vaccine against SARS-COV2 (Pfizer/BioNTech mRNA-BNT162b2). A 58-year-old woman presented with fatigue, distal extremity paresthesias, and severe back pain within 3 days after receiving her first vaccine dose. She developed worsening back pain and paresthesias in distal extremities which prompted her initial presentation to the hospital. By the third week post-vaccine, she developed increasing gait unsteadiness, progression of paresthesias, and new autonomic symptoms including presyncopal episodes and constipation. Neurological exam showed bilateral distal predominant lower extremity weakness, decreased sensation in a length-dependent pattern, and areflexia. EMG/NCS showed a diffuse sensorimotor polyneuropathy with mixed demyelinating and axonal features consistent with GBS. She was treated with 2 g/kg of IVIG over 3 days and also received prednisone 60 mg daily for 3 days for severe back pain, with improvement of symptoms. This possible association with mRNA-based vaccination expands the potential triggers for an autoimmune-based attack on the peripheral nervous system.
Elevated number of IL-21+ TFH and CD86+CD38+ B cells in blood of renal transplant recipients with AMR under conventional immuno-suppression
Authors: Liu Jing , Tang Tongyu , Qu Zhihui , Wang Li , Si Rui , Wang Haifeng , Jiang Yanfang
Published: January 2022

The objective of this study is to detect the number of different subsets of TFH and B cells in renal transplant recipients (RTR) with antibody-mediated acute rejection (AMR), acute rejection (AR), chronic rejection (CR), or transplant stable (TS). The present study was a prospective study. The numbers of ICOS +, PD-1+ and IL-21+ TFH, CD86+, CD38+, CD27+, and IgD- B cells in 21 patients with end-stage renal disease (ESRD) and post-transplant times were measured by flow cytometry. The level of serum IL-21 was detected by ELISA. The numbers of circulating CD4+CXCR5+, CD4+CXCR5+ICOS+, CD4+CXCR5+PD-1+, CD4+CXCR5+IL-21+ TFH, CD19+CD86+, and CD19 +CD86+CD38+ B cells as well as the level of serum IL-21 in the AMR, AR, and CR groups at post-transplantation were significantly higher than those at pre-transplantation. In contrast, the number of circulating CD19+CD27+IgD B cells was significantly increased in the TS groups in respect to the other groups. Moreover, the numbers of circulating CD4+CXCR5+IL-21+ TFH cells, CD19+CD86+CD38+ B cells as well as the level of serum IL-21 were positive related to the level of serum Cr while showing negative correlated with the values of eGFR in the AMR groups at post-transplantation for 4 and 12 weeks. Circulating TFH cells may be a biomarker in RTR with AMR, which can promote the differentiation of B cells into plasma cells by activating B cells, thereby promoting disease progression.
Experiences With Elementary School Counseling Advocacy
Authors: Goodman-Scott Emily , Brown Emily , Berger Carolyn , Blalock Sarah
Published: January 2022

Elementary school counselors are instrumental in student success and well-being; unfortunately, school counselors at the elementary level also have higher caseloads and more tenuous job opportunities. Thus, there exists a need to advocate for elementary school counseling. Previous research has examined school counseling advocacy across K–12 settings and included advocacy as one aspect of larger studies. Given this gap in the literature, we conducted a phenomenological investigation to examine the lived experiences of professionals who reported successfully advocating for elementary school counseling positions and roles. We discuss findings and implications, including applying results to the school counseling profession, in an effort to bolster elementary school counseling and better school counseling services to students.
Heritage’s: MOOving Forward
Authors: Watson Renee D.
Published: January 2022

The first Heritage’s Dairy Store opened in Westville New Jersey on October 10, 1957. The chain of convenient stores is known for their quality lunchmeats, fresh coffee, and their own brand of milk and ice cream. The company wholesales candy, tobacco, and groceries from its Heritage’s Wholesale Company, which supplies more than 75% of products sold in its 33+ locations. Additionally, Heritage’s now offers customizable food options throughout the day. As the business transitions to the next generation, the leadership has noticed changes within their markets, new trends within the industry, and several marketing related challenges. Following marketing research, Heritage’s found the majority of their consumers were over the age of 50. Research also showed many respondents under 25 were unaware of the company. Additionally, many within the 20–39 age bracket who had heard of the company still did not have a clear understanding of the product offerings or overall brand. Heritage’s is faced with maintaining their current consumer base while simultaneously attracting the younger demographic. Additionally, major changes in technology, store design, marketing, and branding would come at a significant cost. Lastly, the management of Heritage’s seeks to honor their company history while looking toward the future.
GCRNN: graph convolutional recurrent neural network for compound–protein interaction prediction
Authors: Elbasani Ermal , Njimbouom Soualihou Ngnamsie , Oh Tae-Jin , Kim Eung-Hee , Lee Hyun , Kim Jeong-Dong
Published: January 2022

Background

Compound–protein interaction prediction is necessary to investigate health regulatory functions and promotes drug discovery. Machine learning is becoming increasingly important in bioinformatics for applications such as analyzing protein-related data to achieve successful solutions. Modeling the properties and functions of proteins is important but challenging, especially when dealing with predictions of the sequence type.

Result

We propose a method to model compounds and proteins for compound–protein interaction prediction. A graph neural network is used to represent the compounds, and a convolutional layer extended with a bidirectional recurrent neural network framework, Long Short-Term Memory, and Gate Recurrent unit is used for protein sequence vectorization. The convolutional layer captures regulatory protein functions, while the recurrent layer captures long-term dependencies between protein functions, thus improving the accuracy of interaction prediction with compounds. A database of 7000 sets of annotated compound protein interaction, containing 1000 base length proteins is taken into consideration for the implementation. The results indicate that the proposed model performs effectively and can yield satisfactory accuracy regarding compound protein interaction prediction.

Conclusion

The performance of GCRNN is based on the classification accordiong to a binary class of interactions between proteins and compounds The architectural design of GCRNN model comes with the integration of the Bi-Recurrent layer on top of CNN to learn dependencies of motifs on protein sequences and improve the accuracy of the predictions.
Fruit ripening: dynamics and integrated analysis of carotenoids and anthocyanins
Authors: Kapoor Leepica , Simkin Andrew J. , George Priya Doss C. , Siva Ramamoorthy
Published: January 2022

Background

Fruits are vital food resources as they are loaded with bioactive compounds varying with different stages of ripening. As the fruit ripens, a dynamic color change is observed from green to yellow to red due to the biosynthesis of pigments like chlorophyll, carotenoids, and anthocyanins. Apart from making the fruit attractive and being a visual indicator of the ripening status, pigments add value to a ripened fruit by making them a source of nutraceuticals and industrial products. As the fruit matures, it undergoes biochemical changes which alter the pigment composition of fruits.

Results

The synthesis, degradation and retention pathways of fruit pigments are mediated by hormonal, genetic, and environmental factors. Manipulation of the underlying regulatory mechanisms during fruit ripening suggests ways to enhance the desired pigments in fruits by biotechnological interventions. Here we report, in-depth insight into the dynamics of a pigment change in ripening and the regulatory mechanisms in action.

Conclusions

This review emphasizes the role of pigments as an asset to a ripened fruit as they augment the nutritive value, antioxidant levels and the net carbon gain of fruits; pigments are a source for fruit biofortification have tremendous industrial value along with being a tool to predict the harvest. This report will be of great utility to the harvesters, traders, consumers, and natural product divisions to extract the leading nutraceutical and industrial potential of preferred pigments biosynthesized at different fruit ripening stages.
An economic evaluation of triage tools for patients with suspected severe injuries in England
Authors: Pollard Daniel , Fuller Gordon , Goodacre Steve , van Rein Eveline A. J. , Waalwijk Job F. , van Heijl Mark
Published: January 2022

Background

Many health care systems triage injured patients to major trauma centres (MTCs) or local hospitals by using triage tools and paramedic judgement. Triage tools are typically assessed by whether patients with an Injury Severity Score (ISS) ≥ 16 go to an MTC and whether patients with an ISS < 16 are sent to their local hospital. There is a trade-off between sensitivity and specificity of triage tools, with the optimal balance being unknown. We conducted an economic evaluation of major trauma triage tools to identify which tool would be considered cost-effective by UK decision makers.

Methods

A patient-level, probabilistic, mathematical model of a UK major trauma system was developed. Patients with an ISS ≥ 16 who were only treated at local hospitals had worse outcomes compared to being treated in an MTC. Nine empirically derived triage tools, from a previous study, were examined so we assessed triage tools with realistic trade-offs between triage tool sensitivity and specificity. Lifetime costs, lifetime quality adjusted life years (QALYs), and incremental cost-effectiveness ratios (ICERs) were calculated for each tool and compared to maximum acceptable ICERs (MAICERs) in England.

Results

Four tools had ICERs within the normal range of MAICERs used by English decision makers (£20,000 to £30,000 per QALY gained). A low sensitivity (28.4%) and high specificity (88.6%) would be cost-effective at the lower end of this range while higher sensitivity (87.5%) and lower specificity (62.8%) was cost-effective towards the upper end of this range. These results were sensitive to the cost of MTC admissions and whether MTCs had a benefit for patients with an ISS between 9 and 15.

Conclusions

The cost-effective triage tool depends on the English decision maker’s MAICER for this health problem. In the usual range of MAICERs, cost-effective prehospital trauma triage involves clinically suboptimal sensitivity, with a proportion of seriously injured patients (at least 10%) being initially transported to local hospitals. High sensitivity trauma triage requires development of more accurate decision rules; research to establish if patients with an ISS between 9 and 15 benefit from MTCs; or, inefficient use of health care resources to manage patients with less serious injuries at MTCs.
Effects of virtual reality-based motor control training on inflammation, oxidative stress, neuroplasticity and upper limb motor function in patients with chronic stroke: a randomized controlled trial
Authors: Huang Chien-Yu , Chiang Wei-Chi , Yeh Ya-Chin , Fan Shih-Chen , Yang Wan-Hsien , Kuo Ho-Chang , Li Ping-Chia
Published: January 2022

Background

Immersive virtual reality (VR)-based motor control training (VRT) is an innovative approach to improve motor function in patients with stroke. Currently, outcome measures for immersive VRT mainly focus on motor function. However, serum biomarkers help detect precise and subtle physiological changes. Therefore, this study aimed to identify the effects of immersive VRT on inflammation, oxidative stress, neuroplasticity and upper limb motor function in stroke patients.

Methods

Thirty patients with chronic stroke were randomized to the VRT or conventional occupational therapy (COT) groups. Serum biomarkers including interleukin 6 (IL-6), intracellular adhesion molecule 1 (ICAM-1), heme oxygenase 1 (HO-1), 8-hydroxy-2-deoxyguanosine (8-OHdG), and brain-derived neurotrophic factor (BDNF) were assessed to reflect inflammation, oxidative stress and neuroplasticity. Clinical assessments including active range of motion of the upper limb and the Fugl-Meyer Assessment for upper extremity (FMA-UE) were also used. Two-way mixed analyses of variance (ANOVAs) were used to examine the effects of the intervention (VRT and COT) and time on serum biomarkers and upper limb motor function.

Results

We found significant time effects in serum IL-6 (p = 0.010), HO-1 (p = 0.002), 8-OHdG (p = 0.045), and all items/subscales of the clinical assessments (ps < 0.05), except FMA-UE-Coordination/Speed (p = 0.055). However, significant group effects existed only in items of the AROM-Elbow Extension (p = 0.007) and AROM-Forearm Pronation (p = 0.048). Moreover, significant interactions between time and group existed in item/subscales of FMA-UE-Shoulder/Elbow/Forearm (p = 0.004), FMA-UE-Total score (p = 0.008), and AROM-Shoulder Flexion (p = 0.001).

Conclusion

This was the first study to combine the effectiveness of immersive VRT using serum biomarkers as outcome measures. Our study demonstrated promising results that support the further application of commercial and immersive VR technologies in patients with chronic stroke.
Corneal confocal microscopic characteristics of acute angle-closure crisis
Authors: Wang Weiwei , Yang Xin , Yao Qian , Xu Qianqian , Liu Wenting , Liu Jianrong
Published: January 2022

Background

To investigate characteristics of the acute angle-closure crisis (AACC) and fellow eyes using confocal microscopy.

Methods

Unilateral AACC patients hospitalized at the Xi’an People’s Hospital from October 2017 to October 2020 were recruited in this cross-sectional study. Age-matched participants scheduled for cataract surgery were enrolled as a healthy control group. Corneal epithelial cells, subepithelial nerve fiber plexus, stromal cells, and endothelial cells were examined by confocal and specular microscopy.

Results

This study enrolled 41 unilateral AACC patients (82 eyes) and 20 healthy controls (40 eyes). Confocal microscopy revealed that the corneal nerve fiber density, corneal nerve branch density and corneal nerve fiber length were reduced significantly in AACC eyes. The stromal cells were swollen and the size of the endothelial cells was uneven with the deposition of punctate high-reflective keratic precipitate on the surface. In severe cases, the cell volume was enlarged, deformed, and fused. The corneal subepithelial nerve fiber, stromal layer, and endothelial layer were unremarkable in the fellow eyes, and the density of the endothelial cells was 2601 ± 529 cells/mm2, which was higher than 1654 ± 999 cells/mm2 in AACC eyes (P < 0.001). Corneal edema prevented the examination of 17 eyes using specular microscopy and in only four eyes using confocal microscopy. There were no significant differences in endothelial cell density between confocal and specular microscopy in the AACC eyes (P = 0.674) and fellow eyes (P = 0.247). The hexagonal cell ratio reduced significantly (P < 0.001), and average cell size and coefficient of variation of the endothelial cells increased significantly compared with fellow eyes (P < 0.001, P = 0.008).

Conclusions

AACC eye showed decreased density and length of corneal subepithelial nerve fiber plexus, activation of stromal cells, increased endothelial cell polymorphism, and decreased density.