bluuebunny/crossref_metadata_2025 huggingface dataset:
Automatic 3D Building Model Generation from Airborne LiDAR Data and OpenStreetMap Using Procedural Modeling
Authors: Župan Robert , Vinković Adam , Nikçi Rexhep , Pinjatela Bernarda
Published: July 2023

This research is primarily focused on utilizing available airborne LiDAR data and spatial data from the OpenStreetMap (OSM) database to generate 3D models of buildings for a large-scale urban area. The city center of Ljubljana, Slovenia, was selected for the study area due to data availability and diversity of building shapes, heights, and functions, which presented a challenge for the automated generation of 3D models. To extract building heights, a range of data sources were utilized, including OSM attribute data, as well as georeferenced and classified point clouds and a digital elevation model (DEM) obtained from openly available LiDAR survey data of the Slovenian Environment Agency. A digital surface model (DSM) and digital terrain model (DTM) were derived from the processed LiDAR data. Building outlines and attributes were extracted from OSM and processed using QGIS. Spatial coverage of OSM data for buildings in the study area is excellent, whereas only 18% have attributes describing external appearance of the building and 6% describing roof type. LASTools software (rapidlasso GmbH, Friedrichshafener Straße 1, 82205 Gilching, GERMANY) was used to derive and assign building heights from 3D coordinates of the segmented point clouds. Various software options for procedural modeling were compared and Blender was selected due to the ability to process OSM data, availability of documentation, and low computing requirements. Using procedural modeling, a 3D model with level of detail (LOD) 1 was created fully automated. After analyzing roof types, a 3D model with LOD2 was created fully automated for 87.64% of buildings. For the remaining buildings, a comparison of procedural roof modeling and manual roof editing was performed. Finally, a visual comparison between the resulting 3D model and Google Earth’s model was performed. The main objective of this study is to demonstrate the efficient modeling process using open data and free software and resulting in an enhanced accuracy of the 3D building models compared to previous LOD2 iterations.
Benzimidazole-Based NHC Metal Complexes as Anticancer Drug Candidates: Gold(I) vs. Platinum(II)
Authors: Kapitza Paul , Grabher Patricia , Scherfler Amelie , Wurst Klaus , Kircher Brigitte , Gust Ronald , Varbanov Hristo P.
Published: July 2023

Herein, we present a comparative study on the chemistry and biological activity of N-heterocyclic carbene (NHC)Pt(II)/Au(I) complexes. Accordingly, representative compounds of the cis/trans- [PtL2X2] (X = Cl (5, 6) or I (7, 8)), [PtL3Cl]+ (9), [AuLX] (X = Cl (10) or I (11)), and [AuL2]+ (12) type, where L is 1,3-diethylbenzimidazol-2-ylidene, were synthesized and characterized in detail to elucidate the role of the metal center on their physicochemical and biological properties. The stability of the complexes in the presence of cell culture medium and their reactivity toward relevant biomolecules were investigated by RP-HPLC. In addition, their effects on plasmid DNA and in vitro cytotoxicity in ovarian cancer cells and non-malignant fibroblasts were evaluated. Cationic [AuL2]+ and [PtL3X]+ species displayed the highest cytotoxicity and stability in cell culture medium in the series. They exhibited IC50 values lower than the established metallodrugs cisplatin and auranofin in both wild-type and cisplatin-resistant ovarian cancer cells, being able to circumvent cisplatin resistance. Finally, Pt(II)–NHC complexes form 5′-guanosine monophosphate adducts under physiologically relevant conditions and interact with plasmid DNA in contrast to their Au(I) analogs, corroborating their distinct modes of action.
Mastering the Best Practices: A Comprehensive Look at the European Guidelines for Cardiopulmonary Bypass in Adult Cardiac Surgery
Authors: Milojevic Milan , Milosevic Goran , Nikolic Aleksandar , Petrovic Masa , Petrovic Ivana , Bojic Milovan , Jagodic Sinisa
Published: July 2023

The successful outcome of a cardiac surgery procedure is significantly dependent on the management of cardiopulmonary bypass (CPB). Even if a cardiac operation is technically well-conducted, a patient may suffer CPB-related complications that could result in severe comorbidities, reduced quality of life, or even death. However, the role of clinical perfusionists in perioperative patient care, which is critical, is often overlooked. Therefore, the European Association for Cardio-Thoracic Surgery (EACTS), the European Association of Cardiothoracic Anaesthesiology (EACTA), and the European Board of Cardiovascular Perfusion (EBCP) have agreed to develop joint clinical practice guidelines (CPGs) for CPB due to its significant impact on patient care and significant variations in practice patterns between countries. The European guidelines, based on the EACTS standardized framework for the development of CPGs, cover the entire spectrum of CPB management in adult cardiac surgery. This includes training and education of clinical perfusionists, machine hardware, disposables, preparation for initiation of CPB, a complete set of procedures during CPB to help maintain end-organ function and anticoagulation, weaning from CPB, and the gaps in evidence and future research directions. This comprehensive coverage ensures that all aspects of CPB management are addressed, providing clinicians with a standardized approach to CPB management based on the latest evidence and best practices. To ensure better integration of these evidence-based recommendations into daily practice, this review aims to provide a general understanding of guideline development and an overview of essential treatment recommendations for CPB management.
Fishing Area Prediction Using Scene-Based Ensemble Models
Authors: Alfatinah Adillah , Chu Hone-Jay , Tatas  , Patra Sumriti Ranjan
Published: July 2023

This study utilized Chlorophyll-a, sea surface temperature (SST), and sea surface height (SSH) as the environmental variables to identify skipjack tuna catch hotspots. This study conducted statistical methods (decision tree, DT, and generalized linear model, GLM) as ensemble models that were employed for predicting skipjack area for each time slice. Using spatial historical data, each model was trained for one of the ensemble model sets. For prediction, the correlations of historical and new inputs were applied to select the predictive model. Using the scene-based model with the highest input correlation, this study further identified the fishing area of skipjack tuna in every case whether the alterations in their environment affected their abundance or not. Overall, the performance achieved over 83% for correlation coefficients (CC) based on the accuracy assessment. This study concluded that DT appears to perform better than GLM in predicting skipjack tuna fishing areas. Moreover, the most influential environmental variable in model construction was sea surface temperature (SST), indicating that the presence of skipjack tuna was primarily influenced by regional temperature.
The Intensification of Prolonged Cooling Climate-Exacerbated Late Ordovician–Early Silurian Mass Extinction: A Case Study from the Wufeng Formation–Longmaxi Formation in the Sichuan Basin
Authors: Zhang Zhibo , Guo Yinghai , Wei Hengye , Zeng Chunlin , Zhang Jiaming , Zhao Difei
Published: July 2023

The Late Ordovician–Early Silurian period was a significant transitional phase in geological history and has garnered global interest. This study focuses on the black shale series of the Wufeng Formation–Longmaxi Formation of the Upper Ordovician–Lower Silurian period in the Sichuan Basin. Based on the logging curves and lithological characteristics of the Yucan-1 Well, 46 black shale samples were collected from the target layer section for clay mineral XRD (46 samples) analysis and whole-rock XRF (14 samples) analysis. The results indicate that three third-order sequences (SQ1, SQ2, and SQ3) are present in the Wufeng Formation–Longmaxi Formation of the Yucan-1 Well, and two subfacies and three microfacies were identified. In conjunction with the characteristics as well as the characteristic parameters of whole-rock oxide and clay mineral content ((I/C), (S + I/S)/(I + C), CIA, CIA-error, CIW, PIA, MAP, and LST), the Wufeng Formation–Longmaxi Formation of the Yucan-1 Well is divided into three intervals. Interval I is the Wufeng Formation. During this interval, weathering intensity, surface temperature, and precipitation gradually decreased, while the climate shifted from warm and humid to cold and dry. This corresponds to two pulse-type biological extinction events and represents an interval of increasing organic carbon burial. Interval II encompasses the bottom-middle part of the Longmaxi Formation. Weathering intensity, surface temperature, and precipitation were characterized by smooth, low values. Subsequently, the climate was predominantly cold and dry. This was the primary interval of organic carbon enrichment. Interval III extends from the upper part to the top of the Longmaxi Formation. Weathering intensity, surface temperature, and precipitation gradually increased. The climate transitioned from cold and dry to warm and humid. Organic carbon burial gradually decreased, while sea levels dropped. This indicates that climate cooling was the primary controlling factor for this biological extinction event. In combination with previous divisions of graptolite zones in the Yucan-1 Well, it is postulated that this biological extinction event may primarily have been pulse extinction. The continuous cooling of the climate in the later period led to the continuous extinction of organisms that survived the disaster. Until approximately 438.76 Ma at the top of the Longmaxi Formation, the climate environment recovered to pre-extinction conditions, with a transition to a warm and humid climate again.
Sleep Quality Aspects in Post-COVID-19 Patients
Authors: Munteanu Ioana , Marc Monica , Gheorghevici Constantin , Diaconu George Alexandru , Feraru Nicolae , Sion Dragos , Nemes Roxana Maria , Mahler Beatrice
Published: July 2023

In this observational cohort study, sleep quality in post-COVID-19 patients was assessed using the Pittsburgh Sleep Quality Index (PSQI) questionnaire. This study aimed to examine aspects of sleep quality in patients who have undergone SARS-CoV-2 infection and if there is a pattern of progression or regression over time (6 months). We also observed and analyzed the results in order to identify any possible links between the severity of COVID-19 and sleep quality as measured by the PSQI questionnaire. The study group consisted of 65 adult patients with confirmed SARS-CoV-2 infection who were referred to a pulmonologist for evaluation. Sleep quality was impacted at a high rate in post-COVID-19 patients, quantified by a PSQI score ≥5. Out of 65 patients, 51% of them had scores greater than or equal to 5. Sleep was subjectively reported as unsatisfactory predominantly in mild and moderate COVID-19 patients. According to the PSQI score and a 6-month follow-up, many patients presented persistency in poor sleep quality. Investigation and individualized treatment of sleep disorders in post-COVID-19 patients should be part of the routine pneumological control, as improvement in sleep quality has an impact not only on the health but also on the psychological state of patients. Educating patients about the importance of sleep and sleep quality impairment should be a primary concern.
Gender Differences in Migrant Workers’ Wages and Their Influencing Factors in the Central Hilly Regions of China
Authors: Fu Zhanhui , Jiang Hongqiang , Qiao Jiajun , Jiang Xiaojun , He Weichun
Published: July 2023

Since the reform and opening up, the socioeconomic status of women in rural China has risen rapidly. However, unlike men, women have not been able to earn higher wages by “working in all directions”. Based on the interview data of 2064 migrant workers, this paper explores the nonlinear interaction of individual characteristics and urban geographic factors with gender differences in migrant workers’ wages with the help of random forest regression models. The results show the following: (1) migrant workers’ wages show obvious gender differences in different dimensions, but in general, men’s wages are higher than women’s wages; (2) there are also gender differences in the influencing factors of migrant workers’ wages. Work experience is more important for male migrant workers’ wages, age is more important for female migrant workers’ wages, and there is a variable effect of each factor on migrant workers’ wages. This paper is of great help in understanding the travel trajectories of migrant workers and gender differences in wages and holds reference value for guiding migrant workers in choosing jobs and places and increasing their income.
Bare Land Referenced Algorithm from Hyper-Temporal Data (BRAH) for Land Use and Land Cover Age Estimation
Authors: Boonprong Sornkitja , Khantachawana Anak
Published: July 2023

Determining the age of land use and land cover (LULC) using satellite imagery has long been one of the challenging tasks in remote sensing research. Accurately determining age, especially crop age, is essential for plot management, biomass calculations, and carbon sequestration. This research proposes a method for determining the age of LULC using hyper-temporal satellite data. The method is based on the assumption that “the starting point for the age count is when the latest bare land status disappears at any location”. To create a geospatial layer (referred to as the BR layer) that can be used to determine the age of any land cover at a specific location, we conditionally stacked such statuses obtained from the analysis of numerous satellite imagery data. The algorithm was tested at two study sites in Thailand, where rubber plantations dominated land use. The study revealed that all the rubber ages determined using BRAH fell accurately within the range of the local government survey data. The manuscript provides a straightforward explanation of the algorithm, including the pseudocode, accuracy assessment, implementations, robustness, and limitations.
Socket Preservation Using Dentin Mixed with Xenograft Materials: A Pilot Study
Authors: Minetti Elio , Palermo Andrea , Savadori Paolo , Patano Assunta , Inchingolo Alessio Danilo , Rapone Biagio , Malcangi Giuseppina , Inchingolo Francesco , Dipalma Gianna , Tartaglia Francesco Carlo , Inchingolo Angelo Michele
Published: July 2023

Background: The use of human dentin matrix could serve as an alternative to autologous, allogenic, and xenogeneic bone grafts due to its osteoinductive characteristics. The limitations of its use is tooth availability and that it is often necessary to mix it with a biomaterial. Aim: The aim of this study was to analyze a mix of two different graft materials with different reabsorption ranges when the dentin graft material was not sufficient for full socket preservation. Methods: Seven socket preservation surgeries were carried out employing a mixed graft material containing 50% dentin and 50% xenograft. After four months of recovery, the implants were positioned. At the time of the prosthesis placement and implant surgery, bone samples were collected. Results: The histologic analysis revealed no inflammatory or infective reaction against the seven biopsies. The histomorphometric graft analysis revealed an amount of New Bone of 29.03 ± 6.57% after 4 months and 34.11 ± 5.02% after 8 months. Conclusions: The two graft materials had a different volume reabsorption rate: 71% after 4 months and 90% after 8 months for dentin, and 6% after 4 months and 26% after 8 months for the xenograft. The space created by the dentin reabsorption increased the quantity of new bone.
Rapid-Hardening and High-Strength Steel-Fiber-Reinforced Concrete: Effects of Curing Ages and Strain Rates on Compressive Performance
Authors: Mo Fan , Li Boxiang , Li Mingyi , Fang Zhuangcheng , Fang Shu , Jiang Haibo
Published: July 2023

High-strength steel-fiber-reinforced concrete (HSFRC) has become increasingly popular as a cast-in-place jointing material in precast concrete bridges and buildings due to its excellent tensile strength and crack resistance. However, working conditions such as emergency repairs and low-temperature constructions require higher demands on the workability and mechanical properties of HSFRC. To this end, a novel rapid-hardening HSFRC has been proposed, which is produced using sulphoaluminate cement (SC) instead of ordinary Portland cement. In this study, quasi-static and dynamic tests were carried out to compare the compressive behavior of conventional and rapid-hardening HSFRCs. The key test variables included SC replacement ratios, concrete curing ages, and strain rates. Test results showed: (1) Rapid-hardening HSFRC exhibited high early strengths of up to 33.14 and 44.9 MPa at the curing age of 4 h, respectively, but its compressive strength and elastic modulus were generally inferior to those of conventional HSFRC. (2) The strain rate sensitivity of rapid-hardening HSFRC was more significant compared to its conventional counterpart and increased with increasing curing ages and strain rates. This study highlights the great potential of rapid-hardening HSFRC in rapid bridge construction.
Influence of the Graphene Oxide on the Pore-Throat Connection of Cement Waste Rock Backfill
Authors: Cheng Zhangjianing , Wang Junying , Hu Junxiang , Lu Shuaijie , Gao Yuan , Zhang Jun , Wang Siyao
Published: July 2023

The pore-throat characteristics significantly affect the consolidated properties, such as the mechanical and permeability-related performance of the cementitious composites. By virtue of the nucleation and pore-infilling effects, graphene oxide (GO) has been proven as a great additive in reinforcing cement-based materials. However, the quantitative characterization reports of GO on the pore-throat connection are limited. This study applied advanced metal intrusion and backscattered electron (BSE) microscopy scanning technology to investigate the pore-throat connection characteristics of the cement waste rock backfill (CWRB) specimens before and after GO modification. The results show that the microscopic pore structure of CWRB is significantly improved by the GO nanosheets, manifested by a decrease in the total porosity up to 31.2%. With the assistance of the GO, the transfer among internal pores is from large equivalent pore size distribution to small equivalent pore size distribution. The fitting relationship between strength enhancement and pore reinforcement efficiency under different pore-throat characteristics reveals that the 1.70 μm pore-throat owns the highest correlation in the CWRB specimens, implying apply GO nanosheets to optimizing the pore-throat under this interval is most efficient. Overall, this research broadens our understanding of the pore-throat connection characteristics of CWRB and stimulates the potential application of GO in enhancing the mechanical properties and microstructure of CWRB.
The Effect of Blocker Application on Color Matching of Different Colored Composite Resin Systems
Authors: Atasayar Emine , Ulusoy Nuran
Published: July 2023

To evaluate the effect of blocker on color matching of different shaded composite systems on natural teeth, 120 anterior teeth were divided into two groups as light and dark shades (n = 60). Round cavities (7 mm in diameter; 2 mm in depth) were prepared on labial surfaces of the teeth. They were restored using three types of resin composites: multi-shaded (Estelite Sigma Quick, Tokuyama Dental, Japan), single-shaded (Omnichroma, Tokuyama Dental, Japan) and group-shaded (Neo Spectra ST, Dentsply Sirona, Germany) (n = 20). Blocker (Omnichroma) was applied to half of the samples in each group (n = 10). Color matching of the restorations with the surrounding tissues were evaluated either by visual analysis or an instrumental method. The resin composites tested did not yield acceptable results instrumentally. Using blocker with single-shade resin composite on dark-colored teeth yielded a minimal change in color in 2 mm deep cavities in the visual evaluation by dentists. Similarly, applying blocker with group-shaded and multi-shaded resin composite on light-colored teeth caused minimal change in color of 2 mm deep cavities in the visual evaluation by dentists. As the application of blocker had no effect on the color matching of different shaded resin composites in the visual evaluations by all observers, except by dentists, blocker may be used as a dentin shade in 2 mm deep cavities of anterior teeth.
Evaluation of Mechanical Properties and Filler Interaction in the Field of SLA Polymeric Additive Manufacturing
Authors: Jirků Petr , Urban Jiří , Müller Miroslav , Kolář Viktor , Chandan Vijay , Svobodová Jaroslava , Mishra Rajesh Kumar , Jamshaid Hafsa
Published: July 2023

The paper deals with research focused on the use of fillers in the field of polymeric materials produced by additive technology SLA (stereolithography). The aim of the research is to evaluate 3D printing parameters, the mechanical properties (tensile strength, hardness), and the interaction of individual phases (polymer matrix and filler) in composite materials using SEM analysis. The tested fillers were cotton flakes and ground carbon fibres in different proportions. For the photosensitive resins, the use of cotton flakes as filler was found to have a positive effect on the mechanical properties not only under static but also under cyclic loading, which is a common cause of material failure in practice. The cyclic stress reference value was set at an amplitude of 5–50% of the maximum force required to break the pure resin in a static tensile test. A positive effect of fillers on the cyclic stress life of materials was demonstrated. The service life of pure resin was only 168 ± 29 cycles. The service life of materials with fillers increased to approximately 400 to 540 cycles for carbon fibre-based fillers and nearly 1000 cycles for cotton flake-based fillers, respectively. In this paper, new composite materials suitable for the use of SLA additive manufacturing techniques are presented. Research demonstrated the possibilities of adding cotton-based fillers in low-cost, commercially available resins. Furthermore, the importance of material research under cyclic loading was demonstrated.
Predicting Popularity of Viral Content in Social Media through a Temporal-Spatial Cascade Convolutional Learning Framework
Authors: Xu Zhixuan , Qian Minghui
Published: July 2023

The viral spread of online content can lead to unexpected consequences such as extreme opinions about a brand or consumers’ enthusiasm for a product. This makes the prediction of viral content’s future popularity an important problem, especially for digital marketers, as well as for managers of social platforms. It is not surprising that conventional methods, which heavily rely on either hand-crafted features or unrealistic assumptions, are insufficient in dealing with this challenging problem. Even state-of-art graph-based approaches are either inefficient to work with large-scale cascades or unable to explain what spread mechanisms are learned by the model. This paper presents a temporal-spatial cascade convolutional learning framework called ViralGCN, not only to address the challenges of existing approaches but also to try to provide some insights into actual mechanisms of viral spread from the perspective of artificial intelligence. We conduct experiments on the real-world dataset (i.e., to predict the retweet popularity of micro-blogs on Weibo). Compared to the existing approaches, ViralGCN possesses the following advantages: the flexible size of the input cascade graph, a coherent method for processing both structural and temporal information, and an intuitive and interpretable deep learning architecture. Moreover, the exploration of the learned features also provides valuable clues for managers to understand the elusive mechanisms of viral spread as well as to devise appropriate strategies at early stages. By using the visualization method, our approach finds that both broadcast and structural virality contribute to online content going viral; the cascade with a gradual descent or ascent-then-descent evolving pattern at the early stage is more likely to gain significant eventual popularity, and even the timing of users participating in the cascade has an effect on future popularity growth.
Research on Financial Default Model with Stochastic Intensity Using Filtered Likelihood Method
Authors: Liu Xiangdong , Wu Jiahui , Li Xianglong
Published: July 2023

This paper investigates the financial default model with stochastic intensity by incomplete data. On the strength of the process-designated point process, the likelihood function of the model in the parameter estimation can be decomposed into the factor likelihood term and event likelihood term. The event likelihood term can be successfully estimated by the filtered likelihood method, and the factor likelihood term can be calculated in a standardized manner. The empirical study reveals that, under the filtered likelihood method, the first model outperforms the other in terms of parameter estimation efficiency, convergence speed, and estimation accuracy, and has a better prediction effect on the default data in China’s financial market, which can also be extended to other countries, which is of great significance in the default risk control of financial institutions.
Metabolic Regulation of Copper Toxicity during Marine Mussel Embryogenesis
Authors: Young Tim , Gale Samantha L. , Ragg Norman L. C. , Sander Sylvia G. , Burritt David J. , Benedict Billy , Le Dung V. , Villas-Bôas Silas G. , Alfaro Andrea C.
Published: July 2023

The development of new tools for assessing the health of cultured shellfish larvae is crucial for aquaculture industries to develop and refine hatchery methodologies. We established a large-volume ecotoxicology/health stressor trial, exposing mussel (Perna canaliculus) embryos to copper in the presence of ethylenediaminetetraacetic acid (EDTA). GC/MS-based metabolomics was applied to identify potential biomarkers for monitoring embryonic/larval health and to characterise mechanisms of metal toxicity. Cellular viability, developmental abnormalities, larval behaviour, mortality, and a targeted analysis of proteins involved in the regulation of reactive oxygen species were simultaneously evaluated to provide a complementary framework for interpretative purposes and authenticate the metabolomics data. Trace metal analysis and speciation modelling verified EDTA as an effective copper chelator. Toxicity thresholds for P. canaliculus were low, with 10% developmental abnormalities in D-stage larvae being recorded upon exposure to 1.10 μg·L−1 bioavailable copper for 66 h. Sublethal levels of bioavailable copper (0.04 and 1.10 μg·L−1) caused coordinated fluctuations in metabolite profiles, which were dependent on development stage, treatment level, and exposure duration. Larvae appeared to successfully employ various mechanisms involving the biosynthesis of antioxidants and a restructuring of energy-related metabolism to alleviate the toxic effects of copper on cells and developing tissues. These results suggest that regulation of trace metal-induced toxicity is tightly linked with metabolism during the early ontogenic development of marine mussels. Lethal-level bioavailable copper (50.3 μg·L−1) caused severe metabolic dysregulation after 3 h of exposure, which worsened with time, substantially delayed embryonic development, induced critical oxidative damage, initiated the apoptotic pathway, and resulted in cell/organism death shortly after 18 h of exposure. Metabolite profiling is a useful approach to (1) assess the health status of marine invertebrate embryos and larvae, (2) detect early warning biomarkers for trace metal contamination, and (3) identify novel regulatory mechanisms of copper-induced toxicity.
A Comprehensive Review on the Roles of Metals Mediating Insect–Microbial Pathogen Interactions
Authors: Khan Subhanullah , Lang Minglin
Published: July 2023

Insects and microbial pathogens are ubiquitous and play significant roles in various biological processes, while microbial pathogens are microscopic organisms that can cause diseases in multiple hosts. Insects and microbial pathogens engage in diverse interactions, leveraging each other’s presence. Metals are crucial in shaping these interactions between insects and microbial pathogens. However, metals such as Fe, Cu, Zn, Co, Mo, and Ni are integral to various physiological processes in insects, including immune function and resistance against pathogens. Insects have evolved multiple mechanisms to take up, transport, and regulate metal concentrations to fight against pathogenic microbes and act as a vector to transport microbial pathogens to plants and cause various plant diseases. Hence, it is paramount to inhibit insect–microbe interaction to control pathogen transfer from one plant to another or carry pathogens from other sources. This review aims to succinate the role of metals in the interactions between insects and microbial pathogens. It summarizes the significance of metals in the physiology, immune response, and competition for metals between insects, microbial pathogens, and plants. The scope of this review covers these imperative metals and their acquisition, storage, and regulation mechanisms in insect and microbial pathogens. The paper will discuss various scientific studies and sources, including molecular and biochemical studies and genetic and genomic analysis.
Metasurfaces and Blinking Jamming: Convergent Study, Comparative Analysis, and Challenges
Authors: Gonçalves Licursi de Mello Rafael
Published: July 2023

Blinking jamming is an active self-screening technique performed by at least two aircraft to tackle monopulse radars and all complexity related thereto. Nowadays, the technique can be performed with digital radiofrequency memories (DRFMs), which are cumbersome, complex, expensive, need a dedicated compartment and antenna, and introduce spurs in the signals. In this paper, we propose an alternative to the implementation of blinking jamming with DRFMs, namely with reconfigurable metasurfaces. By covering the aircraft parts that most contribute to the radar cross-section (RCS), reconfigurable metasurfaces can interchangeably absorb or amplify impinging waves, making the aircraft ‘blink’ from the radar perspective. To validate the feasibility, simulations accounting for realistic phenomena are conducted. It is seen that, if the aircraft RCS can be varied in a ratio of 10:1, either with absorptive or power-amplifying metasurfaces, a performance similar to that of the DRFM is achieved. Furthermore, a ratio of 2:1 is sufficient to make the radar antenna system movements exceed the angular range of the formation. We also anticipate our work to be a starting point for completely new ways of countering radars, e.g., with countless small drones performing passive or active stand-off blinking jamming.
Carbon Capture Using Porous Silica Materials
Authors: Amaraweera Sumedha M. , Gunathilake Chamila A. , Gunawardene Oneesha H. P. , Dassanayake Rohan S. , Cho Eun-Bum , Du Yanhai
Published: July 2023

As the primary greenhouse gas, CO2 emission has noticeably increased over the past decades resulting in global warming and climate change. Surprisingly, anthropogenic activities have increased atmospheric CO2 by 50% in less than 200 years, causing more frequent and severe rainfall, snowstorms, flash floods, droughts, heat waves, and rising sea levels in recent times. Hence, reducing the excess CO2 in the atmosphere is imperative to keep the global average temperature rise below 2 °C. Among many CO2 mitigation approaches, CO2 capture using porous materials is considered one of the most promising technologies. Porous solid materials such as carbons, silica, zeolites, hollow fibers, and alumina have been widely investigated in CO2 capture technologies. Interestingly, porous silica-based materials have recently emerged as excellent candidates for CO2 capture technologies due to their unique properties, including high surface area, pore volume, easy surface functionalization, excellent thermal, and mechanical stability, and low cost. Therefore, this review comprehensively covers major CO2 capture processes and their pros and cons, selecting a suitable sorbent, use of liquid amines, and highlights the recent progress of various porous silica materials, including amine-functionalized silica, their reaction mechanisms and synthesis processes. Moreover, CO2 adsorption capacities, gas selectivity, reusability, current challenges, and future directions of porous silica materials have also been discussed.
Dietary Acid Load and Cancer Risk: A Review of the Uruguayan Experience
Authors: Ronco Alvaro Luis , Storz Maximilian Andreas
Published: July 2023

Dietary acid load (DAL) is recognized as a risk factor for several chronic disorders, including obesity, diabetes, and osteoporosis. Recent evidence suggests that an elevated DAL, as measured by the validated potential renal acid load (PRAL) and net endogenous acid production (NEAP) scores, could also increase the risk for several cancers. This narrative review summarizes the potential role of DAL in Uruguayan cancer patients and outlines the potentially involved pathophysiological pathways that mediate the role of DAL in both cancer development and growth. Although Uruguay is a developing country, its average diet is a heavily meat-based Western one, translating into a supraphysiological acid burden from diet. In recent years, we have published epidemiologic evidence based on ten case-control studies involving 3736 cancer cases and 9534 hospital-based controls. Odds ratios and 95% confidence intervals were estimated for each interest variable to analyze the association between the exposure levels of DAL scores and cancer, calculated by unconditional logistic regression. In a majority of the cases, the highest DAL scores tended to double the cancer risk as compared to the lowest category. We also found high risks for methionine intake, an acidifying amino acid found in higher concentrations in animal-based foods, which may increase cancer risks at least by a joint action based on the pH and the proliferation enhancing properties of the amino acid itself.
Diet Quality Trajectories over Adulthood in a Biracial Urban Sample from the Healthy Aging in Neighborhoods of Diversity across the Life Span Study
Authors: Fanelli Kuczmarski Marie , Beydoun May A. , Georgescu Michael F. , Noren Hooten Nicole , Mode Nicolle A. , Evans Michele K. , Zonderman Alan B.
Published: July 2023

Limited investigation has been done on diet quality trajectories over adulthood. The main study objectives were to determine the diet quality group trajectories (GTs) over time and to detect changes in a socio-economically and racially diverse middle-aged cohort. Data from three waves of the Healthy Aging in Neighborhoods of Diversity across the Life Span (HANDLS) study were used to determine diet quality with group-based trajectory modeling (GBTM). Three quality indices—the Healthy Eating Index (HEI), the Dietary Inflammatory Index (DII), and the Mean Adequacy Ratio (MAR)—were explored. The rate of change in quality over time was determined by mixed-effects regression analysis. Three diet quality GTs, low, middle, and high quality, were identified for each index and confirmed with spaghetti plots. Within each GT, only small changes in diet quality scores were observed, with improvements for the HEI and DII indices and a slight decline in MAR scores. Weighted kappa values revealed that the DII had better agreement with the HEI-2010 and MAR indices compared with the agreement between the HEI-2010 and MAR. Bayesian estimates revealed that the annualized rate of change in diet quality per person across the GTs was similar. There was minimal change in diet quality over time, regardless of the diet quality index used.
n-3 PUFA-Enriched Diet Preserves Skeletal Muscle Mitochondrial Function and Redox State and Prevents Muscle Mass Loss in Mice with Chronic Heart Failure
Authors: Gortan Cappellari Gianluca , Aleksova Aneta , Dal Ferro Matteo , Cannatà Antonio , Semolic Annamaria , Guarnaccia Alberto , Zanetti Michela , Giacca Mauro , Sinagra Gianfranco , Barazzoni Rocco
Published: July 2023

Rationale and Methods: Skeletal muscle derangements, potentially including mitochondrial dysfunction with altered mitochondrial dynamics and high reactive oxygen species (ROS) generation, may lead to protein catabolism and muscle wasting, resulting in low exercise capacity and reduced survival in chronic heart failure (CHF). We hypothesized that 8-week n-3-PUFA isocaloric partial dietary replacement (Fat = 5.5% total cal; EPA + DHA = 27% total fat) normalizes gastrocnemius muscle (GM) mitochondrial dynamics regulators, mitochondrial and tissue pro-oxidative changes, and catabolic derangements, resulting in preserved GM mass in rodent CHF [Myocardial infarction (MI)-induced CHF by coronary artery ligation, left-ventricular ejection fraction <50%]. Results: Compared to control animals (Sham), CHF had a higher GM mitochondrial fission-fusion protein ratio, with low ATP and high ROS production, pro-inflammatory changes, and low insulin signalling. n-3-PUFA normalized all mitochondrial derangements and the pro-oxidative state (oxidized to total glutathione ratio), associated with normalized GM cytokine profile, and enhanced muscle-anabolic insulin signalling and prevention of CHF-induced GM weight loss (all p < 0.05 vs. CHF and p = NS vs. S). Conclusions: n-3-PUFA isocaloric partial dietary replacement for 8 weeks normalizes CHF-induced derangements of muscle mitochondrial dynamics regulators, ROS production and function. n-3-PUFA mitochondrial effects result in preserved skeletal muscle mass, with potential to improve major patient outcomes in clinical settings.
Exploring the Potential of Extracts from Sloanea medusula and S. calva: Formulating Two Skincare Gels with Antioxidant, Sun Protective Factor, and Anti-Candida albicans Activities
Authors: Quintero-Rincón Patricia , Mesa-Arango Ana C. , Flórez-Acosta Oscar A. , Zapata-Zapata Carolina , Stashenko Elena E. , Pino-Benítez Nayive
Published: July 2023

Sloanea is a plant genus, native to tropical regions, used in medicinal practices for its anti-inflammatory properties. This study aimed to determine the antioxidant activity, sun protective factor (SPF), and antifungal of extracts obtained from two species of Sloanea and to develop extract-based gels with antioxidants, photoprotective, and anti-Candida albicans effects. Ethanolic extracts from S. medusula and S. calva collected in Chocó, Colombia, were used for antioxidant activity and SPF determination using the DPPH assay and the Mansur equation, respectively. Extracts were characterized using HPLC-MS and used to prepare the gels. The viscosity of the extract-based gels was evaluated using an MCR92 rheometer. In addition, the anti-Candida activity of extracts against five yeasts and anti-C. albicans of gels were evaluated following the Clinical and Laboratory Standards Institute M27, 4th Edition. High DPPH radical scavenging activity (42.4% and 44.7%) and a high SPF value (32.5 and 35.4) were obtained for the extracts of S. medusula and S. calva, respectively. Similarly, extract-based gels showed significant DPPH radical scavenging activity of 54.5% and 53.0% and maximum SPF values of 60 and 57. Extract from S. medusula showed an important antifungal activity against C. albicans (minimal inhibitory concentration (MIC) of 2 µg/mL). In contrast, S. calva extract was active against C. krusei, C. albicans (MIC of 2 µg/mL) and C. tropicalis (MIC of 4 µg/mL). Sloanea medusula gel (0.15%) exhibited an important C. albicans growth inhibition (98%), while with S. calva gel (0.3%) growth inhibition was slightly lower (76%). Polyphenolic and triterpenoid compounds were tentatively identified for S. medusula and S. calva, respectively. Both extracts can be considered promising sources for developing photoprotective gels to treat skin infections caused by C. albicans.
Synthesis, Characterization, Theoretical and Experimental Anticancer Evaluation of Novel Cocrystals of 5-Fluorouracil and Schiff Bases against SW480 Colorectal Carcinoma
Authors: Jubeen Farhat , Jabeen Ishrat , Aftab Usman , Noor Sadia , Hareem Mah e , Sultan Misbah , Kazi Mohsin
Published: July 2023

The chemotherapeutic agent known as 5-fluorouracil (5-FU) is an artificial fluoropyrimidine antimetabolite that has been widely used for its antineoplastic properties. Cocrystals of 5-fluorouracil (5-FU) with five different Schiff bases (benzylidene-urea (BU), benzylidene-aniline (BA), salicylidene-aniline (SA), salicylidene-phenylhydrazine (SPH), and para-hydroxy benzylideneaniline (HBA)) are reported in this study. The newly synthesized cocrystals were analyzed by FTIR and PXRD. In this study, we investigated the antitumor efficacy of 5-FU derivatives in SW480 colon cancer cells via MTT assay at varying dose concentrations. Molecular docking was performed to predict the binding mechanism of TS with various 5-FU complexes. FTIR revealed the presence of respective functional groups in the prepared cocrystals. The frequencies (v) of N-H (3220.24 cm−1) and carbonyl groups (1662.38 cm−1) in the spectrum of 5-FU shifted considerably in all derivative cocrystal new interactions. There was a noticeable transformation in the PXRD peak of 5-FU at 2θ = 28.37° in all derivatives. The novelty of the present study lies in the fact that 5-FU-BA showed an anticancer potential IC50 (6.4731) far higher than that of 5-FU (12.116), almost comparable to that of the reference drug doxorubicin (3.3159), against SW480 cancel cell lines, followed by 5-Fu-HBA (10.2174). The inhibition rates of 5-FU-BA and 5-FU-HBA were highest among the derivatives (99.85% and 99.37%, respectively) in comparison with doxorubicin (97.103%). The results revealed that the synthesized 5-FU cocrystals have promising antitumor efficacy compared with previously reported 5-FU and 5-FU. The activities of the cocrystals were rationalized by a molecular modeling approach to envisage binding modes with the target cancer protein.
Functionalized Metal Nanoparticles in Cancer Therapy
Authors: Villalobos Gutiérrez Paola , Muñoz Carrillo José , Sandoval Salazar Cuauhtémoc , Viveros Paredes Juan , Gutiérrez Coronado Oscar
Published: July 2023

Currently, there are many studies on the application of nanotechnology in therapy. Metallic nanoparticles are promising nanomaterials in cancer therapy; however, functionalization of these nanoparticles with biomolecules has become relevant as their effect on cancer cells is considerably increased by photothermal and photodynamic therapies, drug nanocarriers, and specificity by antibodies, resulting in new therapies that are more specific against different types of cancer. This review describes studies on the effect of functionalized palladium, gold, silver and platinum nanoparticles in the treatment of cancer, these nanoparticles themselves show an anticancer effect. This effect is further enhanced when the NPs are functionalized with either antibodies, DNA, RNA, peptides, proteins, or folic acid and other molecules. These NPs can penetrate the cell and accumulate in the tumor tissue, resulting in a cytotoxic effect through the generation of ROS, the induction of apoptosis, cell cycle arrest, DNA fragmentation, and a photothermal effect. NP-based therapy is a new strategy that can be used synergistically with chemotherapy and radiotherapy to achieve more effective therapies and reduce side effects.
Comprehensive Kinetic Study of PET Pyrolysis Using TGA
Authors: Alhulaybi Zaid , Dubdub Ibrahim
Published: July 2023

The pyrolysis of polyethylene terephthalate (PET) is a well-known process for producing high fuel value. This paper aims to study the kinetics of PET pyrolysis reactions at 4 different heating rates (2, 5, 10, and 20 K min−1) using thermogravimetric analysis (TGA) data. TGA data show only one kinetic reaction within the temperature ranges of 650 to 750 K. Five different model-free models, namely, the Freidman (FR), Flynn–Wall–Qzawa (FWO), Kissinger–Akahira–Sunose (KAS), Starink (STK), and distributed activation energy model (DAEM), were fitted to the experimental data to obtain the activation energy (Ea) and the pre-exponential factor (A0) of the reaction kinetics. The Coats–Redfern (CR) model equation was fitted with the help of master plot (Criado’s) to identify the most convenient reaction mechanism for this system. Ea’s values were determined by the application of the five aforementioned models and were found to possess an average value of 212 kJ mol−1. The mechanism of PET pyrolysis reaction was best described by first-order reaction kinetics; this was confirmed by the compensation. Further thermodynamic parameter analysis indicated that the reaction was endothermic in nature.
Mechanical Properties of Alginate Hydrogels Cross-Linked with Multivalent Cations
Authors: Malektaj Haniyeh , Drozdov Aleksey D. , deClaville Christiansen Jesper
Published: July 2023

Ionically, cross-linked alginate gels have a potential to be used in a wide range of biomedical, environmental and catalytic applications. The study deals with preparation of alginate hydrogels cross-linked with various cations and the analysis of their equilibrium swelling and mechanical properties. It is shown that the type of cations used in the cross-linking process affects the elastic moduli and the equilibrium degree of swelling of the gels. The experimental data in small-amplitude oscillatory tests are fitted with a model that involves two material parameters: the elastic modulus of a polymer network and a measure of its inhomogeneity. The influence of cations on these quantities is studied numerically. It is revealed that the dependence of the elastic modulus of ionically cross-linked alginate gels on their equilibrium degree of swelling differs from that predicted by the conventional theory for covalently cross-linked gels.
Persistent Free Radicals in Petroleum
Authors: Yañez Jaramillo Lina M. , Tannous Joy H. , de Klerk Arno
Published: July 2023

The persistent free radical content in petroleum is of the order 1018 spins/g (1 μmol/g), with higher and lower values found depending on origin and in different distillation fractions. The field of persistent free radicals in petroleum was reviewed with the aim of addressing and explaining apparent inconsistencies between free radical persistence and reactivity. The macroscopic average free radical concentration in petroleum is persistent over geological time, but individual free radical species in petroleum are short-lived and reactive. The persistent free radical concentration in petroleum can be explained in terms of a dynamic reaction equilibrium of free radical dissociation and association that causes a finite number of species at any given time to be present as free radicals. Evidence to support this description are observed changes in free radical concentration related to change in Gibbs free energy when the bulk liquid properties are changed and responsiveness of free radical concentration to dynamic changes in temperature. Cage effects, solvent effects, steric protection, and radical stabilization affect free radical reaction rate but do not explain the persistent free radical concentration in petroleum. The difference between persistent free radicals in straight-run petroleum and converted petroleum is that straight-run petroleum is an equilibrated mixture, but converted petroleum is not at equilibrium and the free radical concentration can change over time. Based on the limited data available, free radicals in straight-run petroleum appear to be part of the compositional continuum proposed by Altgelt and Boduszynski. Persistent free radical species are partitioned during solvent classification of whole oil, with the asphaltenes (n-alkane insoluble) fraction having a higher concentration of persistent free radicals than maltenes (n-alkane soluble) fraction. Attempts to relate persistent free radical concentration to petroleum composition were inconclusive.