bluuebunny/crossref_metadata_2025 huggingface dataset:
Molecular β-Lactamase Characterization of Aerobic Gram-Negative Pathogens Recovered from Patients Enrolled in the Ceftazidime-Avibactam Phase 3 Trials for Complicated Intra-abdominal Infections, with Efficacies Analyzed against Susceptible and Resistant Subsets
Authors: Mendes Rodrigo E. , Castanheira Mariana , Woosley Leah N. , Stone Gregory G. , Bradford Patricia A. , Flamm Robert K.
Published: March 2017

The correlation of the clinical efficacy of ceftazidime-avibactam (plus metronidazole) with that of meropenem was evaluated in subjects infected with Gram-negative isolates having characterized β-lactam resistance mechanisms from the complicated intra-abdominal infection (cIAI) phase 3 clinical trials.
Enterobacteriaceae
isolates displaying ceftriaxone and/or ceftazidime MIC values of ≥2 μg/ml and
Pseudomonas aeruginosa
isolates with ceftazidime MIC values of ≥16 μg/ml were characterized for extended-spectrum-β-lactamase (ESBL) content.
Enterobacteriaceae
and
P. aeruginosa
isolates with imipenem and meropenem MIC values of ≥2 and ≥8 μg/ml, respectively, were tested for carbapenemase genes. The primary efficacy endpoint was clinical cure at test of cure (TOC) among the members of the microbiologically modified intention-to-treat (mMITT) population. A total of 14.5% (56/387) and 18.8% (74/394) of patients in the ceftazidime-avibactam and meropenem arms had isolates that met the MIC screening criteria at the baseline visit, respectively. CTX-M variants alone (29.7%; 41/138) or in combination with OXA-1/30 (35.5%; 49/138), most commonly,
bla
CTX-M
group 1 variants (79/90; 87.8%), represented the β-lactamases most frequently observed among
Enterobacteriaceae
isolates. Among the patients infected with pathogens that did not meet the screening criteria, 82.2% showed clinical cure in the ceftazidime-avibactam group versus 85.9% in the meropenem group. Among patients infected with any pathogens that met the MIC screening criteria, clinical cure rates at TOC were 87.5% and 86.5% for the ceftazidime-avibactam and meropenem groups, respectively. Ceftazidime-avibactam had clinical cure rates of 92.5% to 90.5% among patients infected with ESBL- and/or carbapenemase-producing
Enterobacteriaceae
strains at the baseline visit, while meropenem showed rates of 84.9% to 85.4%. The ceftazidime-avibactam and meropenem groups had cure rates of 75.0% and 86.7%, respectively, among patients having any pathogens producing AmpC enzymes. The efficacy of ceftazidime-avibactam was similar to that of meropenem for treatment of cIAI caused by ESBL-producing organisms. (This study has been registered at ClinicalTrials.gov under registration no. NCT01499290 and NCT01500239.)
QTwig: A Structural Join Algorithm for Efficient Query Retrieval Based on Region-Based Labeling
Authors: Subramaniam Samini , Haw Su-Cheng , Soon Lay-Ki , Koong Kok-Leong
Published: March 2017

Dependability on XML has increased tremendously over the years. As such the need for efficient query processing technique is certainly important. Despite the fact that these techniques are able to process queries with various edge combinations, they still suffer from processing overheads by buffering large amount of intermediate results particularly for parent–child (P–C) edges. Therefore, in this paper, we propose architecture named ReLaQ, which comprises of two components, ReLab[Formula: see text] (node annotator) and QTwig (query processor) for efficient XML query processing. QTwig improves retrieval time by incorporating a pruning technique that avoids accessing irrelevant data during query processing. Experimental results indicated that ReLaQ superseded TwigStack for both path and twig queries using both regular- and skewed-structured datasets. In addition, this is also proven by means of correctness analysis of ReLaQ.
Dynamics and center of mass energy of colliding particles around black hole in f(R) gravity
Authors: Majeed Bushra , Jamil Mubasher
Published: March 2017

We have investigated the dynamics of particles in the vicinity of a static spherically symmetric black hole in [Formula: see text] gravity. Using the Euler Lagrange method, the dynamical equations of a neutral particle are obtained. Assuming that the particle is initially moving in the innermost stable circular orbit (IMSCO), we have calculated its escape velocity, after a collision with some other particle. The conditions for the escape of colliding particles are discussed. The effective potential and the trajectories of the escaping particles are studied graphically.
ANTECEDENTS OF EMPLOYEE CREATIVITY AND ORGANISATIONAL INNOVATION: AN EMPIRICAL STUDY
Authors: OUAKOUAK MOHAMED LAID , OUEDRAOGO NOUFOU
Published: March 2017

As an important source of organisational innovation, employee creativity is considered by most scholars and practitioners as a must for contemporary organisations. In this vein, organisational members should and must actively engage in generating new and valuable ideas. Various scholars have emphasized the value of identifying and understanding the factors contributing to employee creativity. The purpose of this research is therefore to investigate the factors fostering individual creativity and organisational innovation. To this end, we have developed a conceptual model and tested it with an empirical study based on a sample of 307 participants from Canadian organisations. The results reveal that knowledge sharing and person–organisation fit have positive impacts on individual creativity. Furthermore, personal trust moderates the relationship between business ethics and individual creativity. The results also show that an initiative-friendly culture moderates the impact of individual creativity on organisational innovation.These findings offer a new framework for developing further studies on creativity and innovation, as well as important practical implications for managers.
Preparation and Characterization of Magnetic Cobalt Ferrites/SBA-15 Nanocomposite Adsorbents and the Removal of Methylene Blue
Authors: Chen X. J. , Xu J. C. , Jin H. X. , Jin D. F. , Hong B. , Ge H. L. , Wang X. Q.
Published: March 2017

In this paper, ordered mesoporous SBA-15 silica was synthesized by the hydrothermal method, and then a series of CoFe2O4/SBA-15 nanocomposites were synthesized by a facile impregnation method. X-ray diffraction and N2 adsorption–desorption isotherms were used to characterize the microstructure and morphology of SBA-15 and CoFe2O4/SBA-15 nanocomposites. CoFe2O4 nanoparticles presented spinel phase structure and existed in the mesopores of SBA-15. The magnetic response of CoFe2O4/SBA-15 nanocomposites was characterized with vibrating sample magnetometer (VSM). The adsorption efficiency of CoFe2O4/SBA-15 nanocomposites for methylene blue increased firstly with the increasing CoFe2O4 content, and then decreased. Sample-2 (SBA-15: CoFe2O[Formula: see text]: 0.1 in the precursor) not only presented the best adsorptive performance, but also could be separated and retrieved effectively by magnetic separation technique.
Laser Incision Depth Control in Robot-Assisted Soft Tissue Microsurgery
Authors: Acemoglu Alperen , Fichera Loris , Kepiro Ibolya E. , Caldwell Darwin G. , Mattos Leonardo S.
Published: March 2017

This paper presents the concept of a technology for the automation of laser incisions on soft tissue, especially for application in Transoral Laser Microsurgery (TLM) interventions. The technology aims at automatically controlling laser incisions based on high-level commands from the surgeon, i.e. desired incision shape, length and depth. It is based on a recently developed robotic laser microsurgery platform, which offers the controlled motion of the laser beam on the surgical site. A feed-forward controller provides (i) commands to the robotic laser aiming system and (ii) regulates the parameters of the laser source to achieve the desired results. The controller for the incision depth is extracted from experimental data. The required energy density and the number of passes are calculated to reach the targeted depth. Experimental results demonstrate that targeted depths can be achieved with [Formula: see text]m accuracy, which proves the feasibility of this approach. The proposed technology has the potential to facilitate the surgeon’s control over laser incisions.
AdaFT
Authors: Xu Ye , Koren Israel , Krishna C. Mani
Published: March 2017

Cyber-physical systems (CPS) frequently have to use massive redundancy to meet application requirements for high reliability. While such redundancy is required, it can be activated adaptively, based on the current state of the controlled plant. Most of the time, the plant is in a state that allows for a lower level of fault tolerance. Avoiding the continuous deployment of massive fault tolerance will greatly reduce the workload of the CPS, and lower the operating temperature of the cyber sub-system, thus increasing its reliability. In this article, we extend our prior research by demonstrating a software simulation framework Adaptive Fault Tolerance (AdaFT) that can automatically generate the
sub-spaces
within which our adaptive fault tolerance can be applied. We also show the
theoretical benefits
of AdaFT and its
actual implementation
in several real-world CPSs.
Supporting credibility judgment in web search by Yusuke Yamamoto, with Martin Vesely as coordinator
Authors: Yamamoto Yusuke
Published: March 2017

To support users obtain correct web information and make effective decision during web search, we propose two kinds of search systems. One is a system for helping users to judge the credibility of web search results and to search for credible web pages. This proposed system provides users with the following functions: (1) calculation and visualization of several scores of web search results on the major credibility aspects, (2) prediction of user's credibility judgment model, and (3) re-ranking of web search results based on user's predicted credibility model. The other proposed system suggests suspicious information, promoting more careful information seeking to users during web search and browsing. In this paper, we argue the strong and weak points of the two proposed systems towards credibility-oriented web search.
Examining the context of technical information use
Authors: Öberg Lena-Maria
Published: March 2017

On 9--10 October 2013, the information system research group at Mid Sweden University arranged an international scientific meeting on the theme
Technical Information
(TI). The event's organizers consciously kept the theme broad, but they also intentionally paired this general theme with a number of subthemes, namely
Organizational Learning, Information Design, Information Management
and
Organizational Benefit.
The objective of this design was to examine this overall topic from a range of perspectives.
Ductility and Ultimate Capacity of Prestressed Steel Reinforced Concrete Beams
Authors: Wang Chengquan , Shen Yonggang , Yang Runfang , Wen Zuolin
Published: March 2017

Nonlinear numerical analysis of the structural behaviour of prestressed steel reinforced concrete (PSRC) beams was carried out by using finite element analysis software ABAQUS. By comparing the load‐deformation curves, the rationality and reliability of the finite element model have been confirmed; moreover, the changes of the beam stiffness and stress in the forcing process and the ultimate bearing capacity of the beam were analyzed. Based on the model, the effect of prestressed force, and H‐steel to the stiffness, the ultimate bearing capacity and ductility of beam were also analyzed.
Utilizing CT with Maximum Intensity Projection Reconstruction Bypassing CTA Improves Time to Groin Puncture in Large Vessel Occlusion Stroke Thrombectomy
Authors: Atchaneeyasakul Kunakorn , Tipirneni Anita , Khandelwal Priyank , Saini Vasu , Ronca Richard , Lord Steven , Sur Samir , Guada Luis , Ramdas Kevin , Peterson Eric , Yavagal Dileep
Published: March 2017

Background and Purpose: Prior to thrombectomy for proximal anterior circulation large vessel occlusion (LVO) stroke, recent trials have utilized CT angiography (CTA) for vascular imaging immediately following noncontrast CT (NCCT) for decision-making, but thin-section NCCT with automated maximum intensity projection (MIP) reconstruction also has high accuracy in demonstrating the site of an occluding thrombus. We hypothesized that performing thin-section NCCT with MIP alone prior to thrombectomy improves the time to groin puncture (GP) compared to performing CTA after NCCT. Materials and Methods: We performed a retrospective cohort study of anterior circulation LVO thrombectomy at our tertiary care academic medical center. All stroke patients evaluated with thin-section NCCT (0.625 mm) with automated MIP reconstructions alone and those who had additional CTA were included. We excluded transfer patients, in-hospital strokes, posterior circulation strokes, and patients that were evaluated with stroke imaging other than NCCT or CTA prior to thrombectomy. The study groups were compared for duration from NCCT to GP and total stroke imaging duration. Results: From March 2008 through August 2015, 34 thrombectomy patients met the inclusion/exclusion criteria - 13 in the NCCT and 20 in the NCCT+CTA group. The total stroke imaging duration was shorter in the NCCT group than in the NCCT+CTA group (2 min [1-6] vs. 28 min [23-65]; p < 0.001). The NCCT-only group had a shorter time from NCCT to GP (68 min [32-99] vs. 104 min [79-128]; p = 0.030). Conclusion: Avoiding advanced imaging for patients with anterior circulation LVO in whom thin-section NCCT with MIPs reveals a hyperdense sign significantly shortens the imaging-to-GP time.
Focal Macroscopic Cortical Lesions in Cerebral Autosomal-Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy
Authors: Lyoubi-Idrissi Aicha , De Guio François , Chabriat Hugues , Jouvent Eric
Published: March 2017

Background and Purpose—

Cortical microinfarcts and secondary cortical degeneration have been demonstrated in cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), a severe monogenic cerebral small vessel disease. The aim of this study was to determine whether focal macroscopic cortical lesions can be detected using a specific in vivo magnetic resonance imaging approach.

Methods—

Three-dimensional T1 magnetic resonance imaging scans were obtained in 28 nondemented nondisabled CADASIL patients and 29 age- and sex-matched controls. The cortical mantle of patients and controls were extracted using Brainvisa by an experienced user and then evaluated during a dedicated reading session by a second reader after removing the white matter to stay blind to the clinical status. Thereafter, confirmed focal macroscopic cortical lesions were characterized using all available imaging data, including 7-T magnetic resonance imaging in some patients.

Results—

Three focal macroscopic cortical lesions were confirmed in 3 of 28 patients (11%) but none in controls. All lesions were observed in the close vicinity of severe signal changes in the underlying white matter.

Conclusions—

Focal macroscopic cortical lesions can be detected using specific magnetic resonance imaging approaches in CADASIL patients long before the end stage of the disorder. The underlying mechanisms and precise clinical consequences of these cortical changes still need to be determined.
A monograph of Daviesia (Mirbelieae, Faboideae, Fabaceae)
Authors: CRISP MICHAEL D. , CAYZER LINDY , CHANDLER GREGORY T. , COOK LYN G.
Published: March 2017

Daviesia is a clade of scleromorphic shrubs that are endemic to Australia and its near offshore islands, where it is the largest genus of Fabaceae subfam. Faboideae, with 131 species recognised here. The genus is distributed throughout the continent and occurs in all major habitats except wetlands, rainforest and the alpine zone. This is the first monograph of the genus published since Bentham’s in 1864, which included only 55 species. New taxa described herein are D. divaricata subsp. lanulosa, D. filipes subsp. terminalis, D. subulata, D. schwarzenegger and D. scabrella. New combinations with a change of rank are D. aphylla, D. decurrens subsp. hamata and D. implexa, while D. devito is raised from subspecies level and given a new epithet. A key to species and subspecies, detailed comparative descriptions, phenology and habitat information, as well as line drawings or photographs, are presented for all species. Conservation status is given for taxa of concern, mostly based on assessments by government agencies. A new molecular phylogenetic analysis using sequences of chloroplast and nuclear ribosomal DNA is presented and used to arrange the species descriptions, where the 13 unsequenced species are interpolated using morphological similarity. Seven strongly supported clades and seven mostly well-supported subclades are named informally for reference in discussion of affinities, but are not formally described because they lack morphological synapomorphies.
The rediscovery of Ipomoea macedoi (Convolvulaceae)
Authors: MARINHO ANTONIELA MORAIS , DELGADO-JÚNIOR GEADELANDE CAROLINO , BURIL MARIA TERESA
Published: March 2017

A new population of Ipomoea macedoi, a critically endangered species from Brazil, was found in Chapada do Apodi (Rio Grande do Norte State). The species is recognized by its large, distinctly cordate outer sepals. A detailed description, comments on its distribution and conservation, a taxonomic comparison, photographs and a line drawing are provided.
The genus Leucophenga (Diptera, Drosophilidae), part VII: the subpollinosa species group from China, with morphological and molecular evidence
Authors: HUANG JIA , SU YIRUI , CHEN HONGWEI
Published: March 2017

Seventeen species of Leucophenga subpollinosa species group are described from China (including 11 new species): L. argentina (de Meijere, 1924); L. flavicosta Duda, 1926; L. formosa Okada, 1987; L. nigroscutellata Duda, 1924; L. subpollinosa (de Meijere, 1914); L. umbratula Duda, 1924; L. aculeata sp. nov.; L. acuticauda sp. nov.; L. cultella sp. nov.; L. cyclophylla sp. nov.; L. flaviclypeata sp. nov.; L. fuscipedes sp. nov.; L. gracilenta sp. nov.; L. latipenis sp. nov.; L. magnicauda sp. nov.; L. rhombura sp. nov.; L. rugatifolia sp. nov. A key to all examined species of the subpollinosa group in the present study is provided. The phylogenetic relationships among the 17 species of the subpollinosa group are reconstructed by NJ (Neighbor-joining) and Bayesian analyses using 98 DNA sequences of COI (cytochrome c oxidase subunit I) gene. The pairwise intra- and interspecific p-distances of aforementioned sequences are summarized.
Radiographic Evidence of Occult Intracranial Hypertension in Patients with Ménière’s Disease
Authors: Tawfik Kareem O. , Stevens Shawn M. , Mihal David , Costello Mark S. , Cornelius Rebecca S. , Samy Ravi N. , Pensak Myles L.
Published: March 2017

Objectives

(1) Describe the prevalence of radiographic signs of intracranial hypertension (ICH) in Ménière’s disease (MD) and (2) compare the prevalence of radiographic signs of ICH in MD patients managed medically to those managed surgically.

Study Design

Case‐control study.

Setting

Academic neurotologic practice.

Subjects and Methods

Adult MD patients (aged ≥17 years) treated from 2011 to 2015 were reviewed. Inclusion required magnetic resonance imaging (MRI) of the head and follow‐up >6 months. Patients with intracranial tumors, mass effect, trauma, previous intracranial surgery, and glaucoma were excluded. MD patients were separated by administered treatment into medical and surgical subgroups. Cochlear implant (CI) recipients served as radiographic controls. Eighty‐four MD patients (46 surgical, 38 medical) and 37 CI controls were assessed. MRI measurements assessed for empty/partial sella (ES/PS), dilated/tortuous optic nerve sheath (ONS), and posterior globe flattening (PGF).

Results

Mean age was 53.8 ± 1.3 years and median body mass index (BMI) was 28.2 kg/m2. Of the patients, 64% were female and 92% were white. MRI findings in the MD cohort were as follows: ES/PS, 46.4%; ONS change, 42.8%; and PGF, 8.3%. The prevalence of ONS change was higher in MD patients than in controls (42.8% vs 13.5%, P =. 003). The surgical MD group had higher prevalence of ONS change (52%) compared with the medical group (31.5%, P =. 05) and controls (13.5%, P =. 0004). The surgical group had a higher prevalence of ≥2 simultaneous MRI findings compared with medical MD patients (39% vs 10%, P =. 01) and controls (14%, P =. 01).

Conclusion

MD patients demonstrate a high prevalence of radiographic signs of ICH. MD patients who required surgery had a greater prevalence of radiographic signs of ICH compared with non‐MD patients and medically managed MD patients.
Circadian Misalignment Increases C-Reactive Protein and Blood Pressure in Chronic Shift Workers
Authors: Morris Christopher J. , Purvis Taylor E. , Mistretta Joseph , Hu Kun , Scheer Frank A. J. L.
Published: March 2017

Shift work is a risk factor for inflammation, hypertension, and cardiovascular disease. This increased risk cannot be fully explained by classical risk factors. Shift workers’ behavioral and environmental cycles are typically misaligned relative to their endogenous circadian system. However, there is little information on the impact of acute circadian misalignment on cardiovascular disease risk in shift workers, independent of differences in work stress, food quality, and other factors that are likely to differ between night and day shifts. Thus, our objectives were to determine the independent effect of circadian misalignment on 24-h high-sensitivity C-reactive protein (hs-CRP; a marker of systemic inflammation) and blood pressure levels—cardiovascular disease risk factors—in chronic shift workers. Chronic shift workers undertook two 3-day laboratory protocols that simulated night work, comprising 12-hour inverted behavioral and environmental cycles (circadian misalignment) or simulated day work (circadian alignment), using a randomized, crossover design. Circadian misalignment increased 24-h hs-CRP by 11% ( p < 0.0001). Circadian misalignment increased 24-h systolic blood pressure (SBP) and diastolic blood pressure (DBP) by 1.4 mmHg and 0.8 mmHg, respectively (both p ≤ 0.038). The misalignment-mediated increase in 24-h SBP was primarily explained by an increase in SBP during the wake period (+1.7 mmHg; p = 0.017), whereas the misalignment-mediated increase in 24-h DBP was primarily explained by an increase in DBP during the sleep opportunity (+1.8 mmHg; p = 0.005). Circadian misalignment per se increases hs-CRP and blood pressure in shift workers. This may help explain the increased inflammation, hypertension, and cardiovascular disease risk in shift workers.
Synthesis of ultramarine pigments from Na-A zeolite derived from kaolin waste from the Amazon
Authors: Menezes R.A. , Paz S.P.A. , Angélica R.S. , Neves R.F. , Neumann R. , Faulstich F.R.L. , Pergher S.B.C.
Published: March 2017

Ultramarine pigments were synthesized successfully from Na-A zeolite derived from kaolin waste. Na-A zeolite encapsulates the sulfur species formed and which act as chromophores, which circumvents their oxidation and the subsequent liberation of high levels of toxic gases during the reaction. Different Na-A zeolite matrices with various grain sizes (fine to coarse) were mixed with sulfur and sodium carbonate in various proportions to study the influence of these variables on the pigments’ colours and hues. After calcination at 500°C for 5 h, the products were characterized by X-ray diffraction, X-ray fluorescence and Raman spectroscopy and were classified by the Munsell system (colour and hue). Products with colour ranging from blue to green with various hues were obtained. Both colour and hue were affected by the amount of additives and by the particle size.
Genetic profiling of MYC and BCL2 in diffuse large B-cell lymphoma determines cell-of-origin–specific clinical impact
Authors: Ennishi Daisuke , Mottok Anja , Ben-Neriah Susana , Shulha Hennady P. , Farinha Pedro , Chan Fong Chun , Meissner Barbara , Boyle Merrill , Hother Christoffer , Kridel Robert , Lai Daniel , Saberi Saeed , Bashashati Ali , Shah Sohrab P. , Morin Ryan D. , Marra Marco A. , Savage Kerry J. , Sehn Laurie H. , Steidl Christian , Connors Joseph M. , Gascoyne Randy D. , Scott David W.
Published: March 2017

Key Points

MYC and BCL2 genetic alterations are associated with COO subtype-specific clinical effect in R-CHOP-treated DLBCL.
Outcome of Lower-Risk Patients With Myelodysplastic Syndromes Without 5q Deletion After Failure of Erythropoiesis-Stimulating Agents
Authors: Park Sophie , Hamel Jean-François , Toma Andrea , Kelaidi Charikleia , Thépot Sylvain , Campelo Maria Diez , Santini Valeria , Sekeres Mikkael A. , Balleari Enrico , Kaivers Jennifer , Sapena Rosa , Götze Katharina , Müller-Thomas Catharina , Beyne-Rauzy Odile , Stamatoullas Aspasia , Kotsianidis Ioannis , Komrokji Rami , Steensma David P. , Fensterl Jaime , Roboz Gail J. , Bernal Teresa , Ramos Fernando , Calabuig Marisa , Guerci-Bresler Agnès , Bordessoule Dominique , Cony-Makhoul Pascale , Cheze Stéphane , Wattel Eric , Rose Christian , Vey Norbert , Gioia Daniela , Ferrero Dario , Gaidano Gianluca , Cametti Giovanni , Pane Fabrizio , Sanna Alessandro , Germing Ulrich , Sanz Guillermo F. , Dreyfus François , Fenaux Pierre
Published: March 2017

Purpose

Most anemic patients with non-deleted 5q lower-risk myelodysplastic syndromes (MDS) are treated with erythropoiesis-stimulating agents (ESAs), with a response rate of approximately 50%. Second-line treatments, including hypomethylating agents (HMAs), lenalidomide (LEN), and investigational drugs, may be used after ESA failure in some countries, but their effect on disease progression and overall survival (OS) is unknown. Here, we analyzed outcome after ESA failure and the effect of second-line treatments.

Patients and Methods

We examined an international retrospective cohort of 1,698 patients with non-del(5q) lower-risk MDS treated with ESAs.

Results

Erythroid response to ESAs was 61.5%, and median response duration was 17 months. Of 1,147 patients experiencing ESA failure, 653 experienced primary failure and 494 experienced relapse after a response. Primary failure of ESAs was associated with a higher risk of acute myeloid leukemia (AML) progression, which did not translate into an OS difference. Of 450 patients (39%) who received second-line treatment, 194 received HMAs, 148 received LEN, and 108 received other treatments (MISC), whereas 697 received RBC transfusions only. Five-year AML cumulative incidence was 20.3%, 20.3%, and 11.3% for those receiving HMAs, LEN, and MISC, respectively ( P = .05). Five-year OS for patients receiving HMA, LEN, and MISC was 36.5%, 41.7%, and 51%, respectively ( P = .21). In a multivariable analysis adjusted for age, sex, revised International Prognostic Scoring System score, and progression at ESA failure, there was no significant OS difference among the three groups.

Conclusion

In this large, multicenter, retrospective cohort of patients with non-del(5q) lower-risk MDS treated with ESAs, none of the most commonly used second-line treatments (HMA and LEN) significantly improved OS. Early failure of ESAs was associated with a higher risk of AML progression.
Necrotising fasciitis after laparoscopic rectal cancer surgery
Authors: Yiasemidou M , Majumder S , Basheer M
Published: March 2017

Necrotising fasciitis is a rare, serious infection of the deep fascia leading to subcutaneous tissue necrosis. It is extremely important for this condition to be identified and treated promptly as it bears significant mortality. We describe a case of necrotising fasciitis after laparoscopic rectal cancer surgery. To our knowledge, this is the first case reported after the specific procedure. This case report aims to encourage surgeons to have a low threshold in recognising necrotising fasciitis postoperatively, especially for patients with possible risk factors.
The bedroom tax in the Supreme Court: implications of the judgment
Authors: Meers Jed
Published: March 2017

In common with most decisions of the Supreme Court, the judgment in R. (on the application of Carmichael) v Secretary of State for Work and Pensions [2016] UKSC 58 tells two stories: a short version and a long version. This article outlines both. The short story is the immediate impact of the decision: the application of the high-bar ‘manifestly without reasonable foundation test’, a distinction drawn on ‘transparent medical need’, and the lack of regard given to international obligations under the UNCRPD and the UNCRC. The long story is how this decision fits into the ‘cut-and-devolve’ approach to welfare reform in the UK, where local authorities are left to mitigate the effects of centrally determined benefit reductions without adequate support. After outlining the basis of the decision and its likely effects, this article argues that the decision does little to square this key structural circle at the heart of the UK government's welfare reform agenda.
Mapeamento dos geossistemas e dos sistemas antrópicos como subsídio ao estudo de áreas com riscos a inundações no baixo curso da bacia hidrográfica do rio Muriaé (Rio de Janeiro – Brasil)
Authors: Amorim Raul Reis , Reis Claudio Henrique , Ferreira Carmen
Published: March 2017

Os elementos presentes na paisagem natural e antrópica podem ser indicativos de áreas sujeitas a inundações no baixo curso da Bacia Hidrográfica do Rio Muriaé (RJ). Elaboramos o mapeamento temático que tornou possível identificar elementos naturais e sociais que evidenciam o risco à inundação e alagamentos, bem como suas amplitudes e intensidades. https://doi.org/10.14195/1647-7723_24_7
Trusting the Police
Authors: Staubli Silvia
Published: March 2017

The police can be seen as a governmental institution or as an organizational body, where especially the work - effectiveness, or fairness in encounters - is valued. Through the combination of these approaches and the inclusion of social trust and criminal victimization, Silvia Staubli offers an understanding beyond existing literature on institutional trust and procedural fairness. Moreover, due to analyses for Eastern and Western Europe, she addresses experts from sociology, political science, criminology, and social anthropology equally. Beyond, the study offers an insight to the public on how public opinions towards institutions are shaped.
Klinisch rein
Authors: Bose Käthe von
Published: March 2017

Sauberkeit Macht Arbeit. Mit den Fragen, wer für wen putzt und was unter »sauber« und »schmutzig« verstanden wird, sind viele grundlegende Themen verbunden. Diese ethnografische Studie zeigt, dass es bei dem Thema Sauberkeit auch in Krankenhäusern nicht nur um hygienische Reinheit geht, sondern zugleich um Fragen gesellschaftlicher Arbeitsteilung, um soziale Grenzziehungen, Geschlechterzuschreibungen und die (widerständige) Arbeit an sozialer Ordnung. Käthe von Bose bietet einen detaillierten Einblick in die vielschichtigen Aushandlungen um Sauberkeit und Hygiene sowie die damit befassten Arbeiten von verschiedenen Krankenhausakteur_innen. So macht sie Reinigen als soziale Praxis und als Verdichtung gesellschaftlicher Machtfragen sichtbar.
Racism and Resistance
Authors: Meister Franziska
Published: March 2017

Even a cursory look at U.S. society today reveals that protests against racial discrimination are by no means a thing of the past. What can we learn from past movements in order to understand the workings of racism and resistance? In this book, Franziska Meister revisits the Black Panther Party and offers a new perspective on the Party as a whole and its struggle for racial social justice. She shows how the Panthers were engaged in exposing structural racism in the U.S. and depicts them as uniquely resourceful, imaginative and subversive in the ways they challenged White Supremacy while at the same time revolutionizing both the self-conception and the public image of black people. Meister thus highlights an often marginalized aspect of the Panthers: how they sought to reach a world beyond race - by going through race. A message well worth considering in an age of "color blindness".
Kunsttransfer
Authors: Bertram Ursula
Published: March 2017

Creativity is not a prisoner of Art! Unangepasstes, non-lineares und normfreies Denken und Handeln hat schon immer zu großen künstlerischen Werken, bahnbrechenden Erfindungen und zukunftsweisenden Sichtweisen geführt. Doch wie kommt dieses kostbare Gut in unsere berufliche Alltagswelt, um dabei zu helfen, die sozialen, ökologischen und ökonomischen Herausforderungen zu bewältigen? Es handelt sich um die Synergie des logisch begründbaren Wissens und der Fähigkeit des Navigierens im offenen System. Ursula Bertram hat Tausende von künstlerischen Prozessen begleitet und entwickelt. Sie beobachtete dabei die Strategien und Prinzipien von Künstlern, Theaterregisseuren, Musikern und Querdenkern, verglich sie mit den Erzählungen von Physikern, Mathematikern, Managern und Wissenschaftlern. Durch den Austausch und die Erprobung künstlerischen Denkens in außerkünstlerischen Feldern, so zeigt sie, entsteht ein Muster, genannt Kunsttransfer, das sich als äußerst effizient erweist.
Against Musical ἀτεχνία: Papyrus Hibeh I 13 and the Debate on τέχνη in Classical Greece
Authors: Pelosi Francesco
Published: March 2017

The oration preserved in Papyrus Hibeh I 13 consists in a harsh attack on some self-appointed
CCD Photometry of the Open Cluster Tombaugh 5 in the Vilnius System
Authors: Zdanavičius J. , Vrba F. J. , Zdanavičius K. , Straižys V. , Boyle R. P.
Published: March 2017

We present the results of eight-color CCD photometry of 674 stars in the direction of the open cluster Tombaugh 5 in Camelopardalis. The stars are observed in the Vilnius system supplemented by the broad-band I filter; the field is of 22’ diameter, the limiting magnitude is V =17.7 mag. The catalog contains the coordinates, V magnitudes, seven color indices, two-dimensional spectral types determined from photometric parameters, interstellar extinctions and distances. The color-magnitude diagram plotted for 480 individually dereddened stars is used to identify cluster members and to determine the distance (1.74 kpc) and age (200-250 Myr) of the cluster. The faintest cluster stars classified are of spectral class G0. The cluster contains two blue stragglers of spectral classes B2-B4, both of them seem to be visual binaries. The extinction A
Dark Matter
Authors: Einasto J.
Published: March 2017

I give a review of the development of the concept of dark matter. The dark matter story passed through several stages from a minor observational puzzle to a major challenge for theory of elementary particles. Modern data suggest that dark matter is the dominant matter component in the Universe, and that it consists of some unknown non-baryonic particles. Dark matter is the dominant matter component in the Universe, thus properties of dark matter particles determine the structure of the cosmic web.
Some Relations Between the Stockholm and Tartu Observatories During the 19th Century
Authors: Lindberg Michael
Published: March 2017

This article introduces the Royal Swedish Academy of Sciences and the old Stockholm Observatory. It focuses on the Swedish astronomers Jöns Svanberg and Nils H. Selander, and on their work with the Struve Geodetic Arc. The particular relations to the Tartu Observatory through Oskar Backlund and the contemporary Swedish astronomers in Stockholm are traced.
Equivalent width Measurements in Optical Spectra of Galaxies in Local Clusters: Hints On the Star Formation History in Clusters
Authors: Fritz Jacopo , Poggianti Bianca M. , Cava Antonio , Moretti Alessia
Published: March 2017

Equivalent widths of spectral lines in the optical spectra of galaxies are commonly used to characterize their stellar populations and to get some insight on their evolution. Here we describe a new method to measure automatically equivalent widths of spectral lines with a good accuracy. This makes possible to classify galaxies according to the presence/absence and intensity of [O II] and Hδ lines. Based on these classification criteria, we give a description of the characteristics of the star-forming and post-starburst galaxies in local clusters, and their dependence on the cluster characteristics.
Optical Spectroscopy with the Technology of Virtual Observatory
Authors: Škoda P.
Published: March 2017

The contemporary astronomy is flooded with an exponentially growing petabyte-scaled data volumes produced by powerful ground and space-based instrumentation as well as a product of extensive computer simulations and computations of complex numerical models. The efficient organization and seamless handling of this information avalanche stored in a world-wide spread heterogeneous databases and the facilitation of extraction of new physical knowledge about the Universe is a primary goal of the rapidly evolving astronomical Virtual Observatory (VO). We give an overview of current spectroscopic capabilities of VO and identify the future requirements indispensable for detailed multi-wavelength analysis of huge amounts of spectra in a semi-automatic manner.
On the Gas Temperature Determination from Van Der Waals Broadening in Argon - Neon Microwave Plasmas
Authors: Muñoz José , Dimitrijević Milan S. , Calzada M. D.
Published: March 2017

Recently we proposed a method to determine the gas temperature using the van der Waals broadening of atomic spectral lines for atmospheric pressure Ar-He plasma. Here our investigations are continued by studying the influence of Ar*-Ne interactions in order to enlarge the applicability of the proposed method for the determination of gas temperature in argon - neon mixtures. The Ar I 425.9 nm line is found to be suitable for the gas temperature determination.
Symbiotic Stars: Observations Confront Theory
Authors: Mikołajewska J.
Published: March 2017

In this paper, I present and discuss some recent observational results which may have important implications for our understanding of late phases of binary evolution.
The ANS Collaboration Monitoring Program
Authors: Munari U. , Bacci S. , Baldinelli L. , Castellani F. , Cetrulo G. , Cherini G. , Dallaporta S. , Dallavia G. , Englaro A. , Frigo A. , Graziani M. , Luppi V. , Maitan A. , Marangoni C. , Milani A. , Moretti S. , Moschini F. , Ochner P. , Siviero A. , Righetti G. L. , Tomaselli S. , Tomasoni S. , Vagnozzi A. , Valisa P.
Published: March 2017

ANS Collaboration is a growing Italian network of small and medium size telescopes performing spectroscopy (low and medium resolution single dispersion, and Echelle high resolution modes) and UBV RCIC CCD photometry of symbiotic stars and novae mainly, but with interest also on other types of objects like optical transients, eclipsing binaries, X-ray source counterparts and on-call follow-up observations of selected targets from some surveys like IPHAS or RAVE. In the present form ANS started operations in 2005, and at the time of writing has logged on symbiotic stars 14602 photometric runs and a rich ensemble of low and high resolution, absolutely fluxed spectra. the paper describes the internal organization, operation modes and procedures, and presents sample data and performance statistics.
New Symbiotic Stars Monitored with the Hermes Spectrograph: A Case Study of Orbital Hα Modulation
Authors: Jorissen Alain , Van Eck S. , Dermine T. , Van Winckel H. , Gorlova N.
Published: March 2017

We present new orbital elements for two symbiotic systems involving a giant of spectral type S, namely V420 Hya and ER Del. These orbital elements are compared with existing elements for S-type binaries and for symbiotic binaries with M-giant primaries. It is shown that among the S-type binaries, most of the short-period systems (with P in the range 300 - 1000 d) exhibit some kind of symbiotic activity (Hα emission, UV continuum, hard X-rays), but symbiotic systems are not restricted to the short-period systems. the complex and varying Hα profile of V420 Hya has been decomposed to several components (broad emission with σ ~ 140 km/s, narrow emission with σ ~ 60 km/s, and narrow absorption components). Their orbital modulation reveals that the broad emission is located close to the companion (under the hypothesis of a system with a mass ratio Mg/Mc = 2), and that this broad emission is mutilated by absorption from matter located along the line of sight and flowing towards the observer (faster than the giant) at all orbital phases.
Spectroscopic Monotoring of the Symbiotic Star BX Monocerotis
Authors: Anupama G. C. , Kamath U. S. , Gurugubelli U. K. , Mikołajewska J.
Published: March 2017

Low resolution optical spectra of the symbiotic star BX Monocerotis in the 3500-9000 Å range obtained during 1999–2010 are described. the spectrum of BX Mon at all phases is dominated by the cool component, with a red continuum and TiO absorption. Emission lines, predominantly due to HI, He I, He II, Fe II, Ca II and [O III] are seen superimposed on the spectrum of the M5III star, with variable intensities. the observed variations in the spectra seem to be correlated with the orbital phases.
SBS 0802+529: A New Variable Star from the Second Byurakan Survey
Authors: Chavushyan V. , Erastova L. , Tovmassian G. , Torrealba J. , Valdez J. R.
Published: March 2017

A new emission line star was discovered on the plates of the Second Byurakan Survey (SBS). the follow up spectroscopy demonstrated that the object had a spectrum dominated by a late-type giant star with superposed hydrogen emission lines. the object resembles a pulsating Mira, but the amplitude of variability and a rapid UV variability are quite unusual for a single star, and we tentatively classify the object as a symbiotic star.
Science with the VO: Spectroscopic Studies of Herbig Ae/Be Stars
Authors: Baines D. , Gonzalez J. , Arviset C. , Barbarisi I. , Laruelo A. , Leon I. , Landaluce I. Ortiz de , Osuna P. , Rios C. , Salgado J.
Published: March 2017

The Virtual Observatory (VO) is opening up new ways of exploiting the huge amount of data provided by the ever growing number of ground-based and space facilities. Using VOSpec, a multi-wavelength spectral analysis tool developed by the ESA-VO Team at ESAC, and new developments on scripting with VOSpec (VOScript), we have started to undertake a comprehensive study of spectroscopic and photometric data in the VO on Herbig Ae/Be stars. By studying line strengths, variabilities and spectral energy distributions, from the X-ray to sub-millimeter ranges, we aim to gain insights into processes and disk properties of a large sample of these objects. This paper presents initial findings of the spectroscopic analysis and initial spectral energy distribution classifications.
The Lower Main Sequence of Stars in the Solar Neighborhood: Model Predictions Versus Observation
Authors: Bartašiūtė S. , Deveikis V. , Raudeliūnas S. , Sperauskas J.
Published: March 2017

We have used the Simbad database and VizieR catalogue access tools to construct the observational color-absolute magnitude diagrams of nearby K-M dwarfs with precise Hipparcos parallaxes (σπ/π ≤ 0:05). Particular attention has been paid to removing unresolved double/multiple stars and variables. In addition to archival data, we have made use of nearly 2000 new radial-velocity measurements of K-M dwarfs to identify spectroscopic binary candidates. The main sequences, cleaned from unresolved binaries, variable stars, and old population stars which can also widen the sequence due to their presumably lower metallicity, were compared to available solar-metallicity models. Significant offsets of most of the model main-sequence lines are seen with respect to observational data, especially for the lower-mass stars. Only the location and slope of the Victoria-Regina and, partly, BaSTI isochrones match the data quite well.
Chemical Composition of a Young Star HD 377
Authors: Kipper Tõnu
Published: March 2017

A high resolution spectrum of a pre-main sequence star HD 377 is analyzed. The atmospheric parameters are found to be: Teff=5875 K, log g = 4.25 and the microturbulent velocity ξt= 1.40 kms−1. The metallicity of HD377 is slightly higher than of the Sun, [Fe/H]=0.21. The lithium abundance is very high log ε(Li) = 3.02.
A novel keratin 10 gene mutation causing epidermolytic hyperkeratosis (bullous congenital ichthyosiform erythroderma) in a term neonate
Authors: Pegu Satyaranjan , Bodani Jaya. P. , Lemire Edmond G. , Holfeld Karen I.
Published: March 2017

Epidermolytic hyperkeratosis (EHK) is a rare skin condition characterized by erythroderma and blistering at birth, leading to generalized hyperkeratosis of varying severity in adulthood. EHK is frequently mistaken for staphylococcal scalded skin syndrome (SSSS) or epidermolysis bullosa. EHK is usually inherited in an autosomal dominant fashion, but very rare autosomal recessive families have been reported. Molecular genetic testing in this patient identified a novel homozygous keratin-10 gene (KRT10) mutation consistent with autosomal recessive inheritance. Furthermore, diagnosis was achieved by molecular genetic testing circumventing the need to perform a skin biopsy.
On the gate complexity of reversible circuits consisting of NOT, CNOT and 2-CNOT gates
Authors: Zakablukov Dmitry V.
Published: March 2017

The paper is concerned with the problem of complexity of reversible circuits consisting of NOT, CNOT and 2-CNOT gates. For a reversible circuit implementing a map

f
:

Z

2
n

→

Z

2
n

$f: \mathbb Z_2^n\, \to\, \mathbb Z_2^n$

we define the Shannon complexity function L(n, q) as a function of n and the number q of additional inputs in the circuit. We prove the lower estimate

L
(
n
,
q
)

⩾

2
n

(
n
−
2
)

3

log
2

⁡
(
n
+
q
)

−

n
3

$L(n,q)\, \geqslant\, \displaystyle\frac{2^n(n-2)}{3\log_2(n+q)} - \frac{n}{3}$

for the complexity of a reversible circuit and derive the upper estimate L(n, 0) ⩽ 48n2
n
(1 + o(1)) / log2
n if there are no additional inputs. The asymptotic upper estimate for the complexity is shown to be L(n, q
0) ≲ 2
n
with q
0 ∽ n2
n−o(n) additional inputs.
A Simple Ultra-Wideband Magneto-Electric Dipole Antenna With High Gain
Authors: Shuai Chen-yang , Wang Guang-ming
Published: March 2017

A simple ultra-wideband magneto-electric dipole antenna utilizing a differential-fed structure is designed. The antenna mainly comprises three parts, including a novel circular horned reflector, two vertical semicircular shorted patches as a magnetic dipole, and a horizontal U-shaped semicircular electric dipole. A differential feeding structure working as a perfect balun excites the designed antenna. The results of simulation have a good match with the ones of measurement. Results indicate that the designed antenna achieves a wide frequency bandwidth of 107 % which is 3.19~10.61 GHz, when VSWR is below 2. Via introducing the circular horned reflector, the designed antenna attains a steady and high gain of 12±1.5dBi. Moreover, settled broadside direction main beam, high front-to-back ratio, low cross polarization, and the symmetrical and relatively stable radiation patterns in the E-and H-plane are gotten in the impedance bandwidth range. In the practical applications, the proposed antenna that is dc grounded and has a simple structure satisfies the requirement of many outdoor antennas.
Effects of Rare Earth on Mechanical Properties of LZ50 Axle Steels and Its Formation Mechanism
Authors: Zhang Jin-ling , Yu Yan-chong , Wang She-bin , Hou Yang , Yin Shu-chun
Published: March 2017

To study the mechanism of rare earth (RE) elements on the mechanical properties of axle steels, trace RE were added to LZ50 axle steel, which was melted in vacuum induction furnace. By calculating the thermodynamic and kinetic of RE inclusions, the formation mechanism of inclusions was discussed. And the effects of RE elements on the microstructures and mechanical properties were investigated. The results show that RE and O elements in the molten steels diffused into the interface and increased the thickness of the liquid film. The inclusions transform into 1–3 μm spherical RE compound inclusions instead of 5 μm Al2O3-SiO2 with sharp edges. The grain sizes of the steels containing 0.0010 %～0.0026 % RE were decreased, impact toughness and fatigue resistance were improved greatly, compared with the steel without RE. The impact toughness and fatigue resistance of the LZ50 steel with the addition of 0.0010 % RE were increased by 1.65 and 2 times, respectively.