bluuebunny/crossref_metadata_2025 huggingface dataset:
Design, Plant Test and CFD Calculation of a Turbocharger for a Low-Speed Engine
Authors: Borovkov Aleksey , Voinov Igor , Galerkin Yuri , Kaminsky Roman , Drozdov Aleksandr , Solovyeva Olga , Soldatova Kristina
Published: November 2020

Various approaches and techniques are used to design centrifugal compressors. These are engineering one-dimensional and quasi-three-dimensional programs, as well as CFD Computational Fluid Dynamics (CFD) programs. The final judgment about the effectiveness of the design is given by testing the compressor or its model. A centrifugal compressor for an internal combustion engine turbocharger was designed jointly by the Research Laboratory “Gas Dynamics of Turbomachines” of Peter the Great St. Petersburg Polytechnic University (SPbPU) and RPA (Research and Production Association) “Turbotekhnika”. To check its dimensionless characteristics, the compressor was tested with two geometrically similar impellers with a diameter of 175 (TKR 175E) and 140 mm (TKR 140E). The mathematical model of the Universal Modeling Method calculates the efficiency in the design mode for all tests of both compressors with an error of 0.89%, and the efficiency for the entire characteristic with an error of 1.55%. The characteristics of the TKR 140E compressor were calculated using the ANSYS commercial CFD software. For TKR-140E, a significant discrepancy in the value of the efficiency was obtained, but a good agreement in the area of operation, which was not achieved in previous calculations. According to the calculation, the work coefficient is overestimated by 9%, which corresponds to the results of previous calculations by the authors.
The Balanchine Dilemma: “So-Called Abstraction” and the Rhetoric of Circumvention in Black-and-White Ballets
Authors: Tomić-Vajagić Tamara
Published: November 2020

Choreographer George Balanchine was known for rejecting the premise that his ballets were abstract. Yet, a closer look into his comments on abstraction reveals a greater degree of ambivalence toward the concept than previously noticed. His influential words found response in dance critical writing, where the term “abstract” continued to circulate, but was often applied in vague ways, such as “so-called abstraction.” This and other softened terminological variations formed an ambiguous collection of abstractive terms, like a vague word cloud around the dance concept. This article explores abstraction in Balanchine’s particular ballets, and makes a two-fold argument. On the one hand, by emphasizing the visual aspects of Balanchine’s compositions, we may uncover ways to untangle his dilemma about dance abstraction. Visual theories of “semantic abstraction” by Harold Osborne, and of “the gesture of abstraction” by Blake Stimson, may help us to understand the abstractive modes in several of Balanchine’s black-and-white ballets. On the other hand, whether discussed or not, Balanchine’s abstractive gestures have created powerful representational shifts in some cases. In particular, by examining the interracially cast duet from the ballet Agon (1957) as a visual case study, we may see how Balanchine’s rejections of the concept, amplified by critics’ vague terminological invocations of, or silence about, abstractive choreographic gestures, occluded the work’s participation in the discourse of abstraction. Simultaneously, unnoticed yet potent choreographic gestures of semantic abstraction may have promoted whiteness as a normative structure, one that relies on a hegemonic “bodily integrity” (as discussed by Saidiya Hartman). Such an analysis leads to a recognition that Balanchine’s abstraction could have been a subversive form of dissent similar to Kobena Mercer’s concept of “discrepant abstraction.” However, I posit that, as a result of the Balanchine dilemma and its influence, the interlinked gestures of an abstract nature that have not been recognized as such promoted the self-regulative structure identified by Bojana Cvejić as “white harmony.” Ultimately, a more specific and clear application of the term “abstract” in ballet is needed, as it can help to dismantle or disrupt the system of white supremacy operative in dominant ballet structures.
Interrogating Host Antiviral Environments Driven by Nuclear DNA Sensing: A Multiomic Perspective
Authors: Howard Timothy R. , Cristea Ileana M.
Published: November 2020

Nuclear DNA sensors are critical components of the mammalian innate immune system, recognizing the presence of pathogens and initiating immune signaling. These proteins act in the nuclei of infected cells by binding to foreign DNA, such as the viral genomes of nuclear-replicating DNA viruses herpes simplex virus type 1 (HSV-1) and human cytomegalovirus (HCMV). Upon binding to pathogenic DNA, the nuclear DNA sensors were shown to initiate antiviral cytokines, as well as to suppress viral gene expression. These host defense responses involve complex signaling processes that, through protein–protein interactions (PPIs) and post-translational modifications (PTMs), drive extensive remodeling of the cellular transcriptome, proteome, and secretome to generate an antiviral environment. As such, a holistic understanding of these changes is required to understand the mechanisms through which nuclear DNA sensors act. The advent of omics techniques has revolutionized the speed and scale at which biological research is conducted and has been used to make great strides in uncovering the molecular underpinnings of DNA sensing. Here, we review the contribution of proteomics approaches to characterizing nuclear DNA sensors via the discovery of functional PPIs and PTMs, as well as proteome and secretome changes that define a host antiviral environment. We also highlight the value of and future need for integrative multiomic efforts to gain a systems-level understanding of DNA sensors and their influence on epigenetic and transcriptomic alterations during infection.
Antiproliferative, Antimicrobial and Antiviral Activity of β-Aryl-δ-iodo-γ-lactones, Their Effect on Cellular Oxidative Stress Markers and Biological Membranes
Authors: Włoch Aleksandra , Stygar Dominika , Bahri Fouad , Bażanów Barbara , Kuropka Piotr , Chełmecka Elżbieta , Pruchnik Hanna , Gładkowski Witold
Published: November 2020

The aim of this work was the examination of biological activity of three selected racemic cis-β-aryl-δ-iodo-γ-lactones. Tested iodolactones differed in the structure of the aromatic fragment of molecule, bearing isopropyl (1), methyl (2), or no substituent (3) on the para position of the benzene ring. A broad spectrum of biological activity as antimicrobial, antiviral, antitumor, cytotoxic, antioxidant, and hemolytic activity was examined. All iodolactones showed bactericidal activity against Proteus mirabilis, and lactones 1,2 were active against Bacillus cereus. The highest cytotoxic activity towards HeLa and MCF7 cancer cell lines and NHDF normal cell line was found for lactone 1. All assessed lactones significantly disrupted antioxidative/oxidative balance of the NHDF, and the most harmful effect was determined by lactone 1. Contrary to lactone 1, lactones 2 and 3 did not induce the hemolysis of erythrocytes after 48 h of incubation. The differences in activity of iodolactones 1–3 in biological tests may be explained by their different impact on physicochemical properties of membrane as the packing order in the hydrophilic area and fluidity of hydrocarbon chains. This was dependent on the presence and type of alkyl substituent. The highest effect on the membrane organization was observed for lactone 1 due to the presence of bulky isopropyl group on the benzene ring.
MicroRNA, Diabetes Mellitus and Colorectal Cancer
Authors: Wang Hsiuying
Published: November 2020

Diabetes mellitus (DM) is an endocrinological disorder that is due to either the pancreas not producing enough insulin, or the body does not respond appropriately to insulin. There are many complications of DM such as retinopathy, nephropathy, and peripheral neuropathy. In addition to these complications, DM was reported to be associated with different cancers. In this review, we discuss the association between DM and colorectal cancer (CRC). CRC is the third most commonly diagnosed cancer worldwide that mostly affects older people, however, its incidence and mortality are rising among young people. We discuss the relationship between DM and CRC based on their common microRNA (miRNA) biomarkers. miRNAs are non-coding RNAs playing important functions in cell differentiation, development, regulation of cell cycle, and apoptosis. miRNAs can inhibit cell proliferation and induce apoptosis in CRC cells. miRNAs also can improve glucose tolerance and insulin sensitivity. Therefore, investigating the common miRNA biomarkers of both DM and CRC can shed a light on how these two diseases are correlated and more understanding of the link between these two diseases can help the prevention of both DM and CRC.
TrkB-Targeted Therapy for Mucoepidermoid Carcinoma
Authors: Wagner Vivian P. , Martins Manoela D. , Amoura Esra , Zanella Virgilio G. , Roesler Rafael , de Farias Caroline B. , Bingle Colin D. , Vargas Pablo A. , Bingle Lynne
Published: November 2020

The brain-derived neurotrophic factor (BDNF)/tyrosine receptor kinase B (TrkB) pathway was previously associated with key oncogenic outcomes in a number of adenocarcinomas. The aim of our study was to determine the role of this pathway in mucoepidermoid carcinoma (MEC). Three MEC cell lines (UM-HMC-2, H253 and H292) were exposed to Cisplatin, the TrkB inhibitor, ANA-12 and a combination of these drugs. Ultrastructural changes were assessed through transmission electron microscopy; scratch and Transwell assays were used to assess migration and invasion; and a clonogenic assay and spheroid-forming assay allowed assessment of survival and percentage of cancer stem cells (CSC). Changes in cell ultrastructure demonstrated Cisplatin cytotoxicity, while the effects of ANA-12 were less pronounced. Both drugs, used individually and in combination, delayed MEC cell migration, invasion and survival. ANA-12 significantly reduced the number of CSC, but the Cisplatin effect was greater, almost eliminating this cell population in all MEC cell lines. Interestingly, the spheroid forming capacity recovered, following the combination therapy, as compared to Cisplatin alone. Our studies allowed us to conclude that the TrkB inhibition, efficiently impaired MEC cell migration, invasion and survival in vitro, however, the decrease in CSC number, following the combined treatment of ANA-12 and Cisplatin, was less than that seen with Cisplatin alone; this represents a limiting factor.
Sensitization of Cutaneous Primary Afferents in Bone Cancer Revealed by In Vivo Calcium Imaging
Authors: de Clauser Larissa , Luiz Ana P. , Santana-Varela Sonia , Wood John N. , Sikandar Shafaq
Published: November 2020

Cancer-induced bone pain (CIBP) is a complex condition, comprising components of inflammatory and neuropathic processes, but changes in the physiological response profiles of bone-innervating and cutaneous afferents remain poorly understood. We used a combination of retrograde labelling and in vivo calcium imaging of bone marrow-innervating dorsal root ganglia (DRG) neurons to determine the contribution of these cells in the maintenance of CIBP. We found a majority of femoral bone afferent cell bodies in L3 dorsal root ganglia (DRG) that also express the sodium channel subtype Nav1.8—a marker of nociceptive neurons—and lack expression of parvalbumin—a marker for proprioceptive primary afferents. Surprisingly, the response properties of bone marrow afferents to both increased intraosseous pressure and acid were unchanged by the presence of cancer. On the other hand, we found increased excitability and polymodality of cutaneous afferents innervating the ipsilateral paw in cancer bearing animals, as well as a behavioural phenotype that suggests changes at the level of the DRG contribute to secondary hypersensitivity. This study demonstrates that cutaneous afferents at distant sites from the tumour bearing tissue contribute to mechanical hypersensitivity, highlighting these cells as targets for analgesia.
Correlating Radiomic Features of Heterogeneity on CT with Circulating Tumor DNA in Metastatic Melanoma
Authors: Gill Andrew B , Rundo Leonardo , Wan Jonathan C. M. , Lau Doreen , Zawaideh Jeries P. , Woitek Ramona , Zaccagna Fulvio , Beer Lucian , Gale Davina , Sala Evis , Couturier Dominique-Laurent , Corrie Pippa G. , Rosenfeld Nitzan , Gallagher Ferdia A.
Published: November 2020

Clinical imaging methods, such as computed tomography (CT), are used for routine tumor response monitoring. Imaging can also reveal intratumoral, intermetastatic, and interpatient heterogeneity, which can be quantified using radiomics. Circulating tumor DNA (ctDNA) in the plasma is a sensitive and specific biomarker for response monitoring. Here we evaluated the interrelationship between circulating tumor DNA mutant allele fraction (ctDNAmaf), obtained by targeted amplicon sequencing and shallow whole genome sequencing, and radiomic measurements of CT heterogeneity in patients with stage IV melanoma. ctDNAmaf and radiomic observations were obtained from 15 patients with a total of 70 CT examinations acquired as part of a prospective trial. 26 of 39 radiomic features showed a significant relationship with log(ctDNAmaf). Principal component analysis was used to define a radiomics signature that predicted ctDNAmaf independent of lesion volume. This radiomics signature and serum lactate dehydrogenase were independent predictors of ctDNAmaf. Together, these results suggest that radiomic features and ctDNAmaf may serve as complementary clinical tools for treatment monitoring.
PARPs, PAR and NAD Metabolism and Their Inhibitors in Cancer
Authors: Curtin Nicola , Bai Péter
Published: November 2020

The role of poly(ADP-ribose) polymerase-1 (PARP1) in DNA repair and as a potential target for anticancer therapy has been under investigation for more than 50 years [...]
Contrast-Enhanced Mammography for Screening Women after Breast Conserving Surgery
Authors: Gluskin Jill , Rossi Saccarelli Carolina , Avendano Daly , Marino Maria Adele , Bitencourt Almir G. V. , Pilewskie Melissa , Sevilimedu Varadan , Sung Janice S. , Pinker Katja , Jochelson Maxine S.
Published: November 2020

To investigate the value of contrast-enhanced mammography (CEM) compared to full-field digital mammography (FFDM) in screening breast cancer patients after breast-conserving surgery (BCS), this Health Insurance Portability and Accountability Act-compliant, institutional review board-approved retrospective, single-institution study included 971 CEM exams in 541 asymptomatic patients treated with BCS who underwent screening CEM between January 2013 and November 2018. Histopathology, or at least a one-year follow-up, was used as the standard of reference. Twenty-one of 541 patients (3.9%) were diagnosed with ipsi- or contralateral breast cancer: six (28.6%) cancers were seen with low-energy images (equivalent to FFDM), an additional nine (42.9%) cancers were detected only on iodine (contrast-enhanced) images, and six interval cancers were identified within 365 days of a negative screening CEM. Of the 10 ipsilateral cancers detected on CEM, four were detected on low-energy images (40%). Of the five contralateral cancers detected on CEM, two were detected on low-energy images (40%). Overall, the cancer detection rate (CDR) for CEM was 15.4/1000 (15/971), and the positive predictive value (PPV3) of the biopsies performed was 42.9% (15/35). For findings seen on low-energy images, with or without contrast, the CDR was 6.2/1000 (6/971), and the PPV3 of the biopsies performed was 37.5% (6/16). In the post-BCS screening setting, CEM has a higher CDR than FFDM.
Time-Dependent Anti-Demineralization Effect of Silver Diamine Fluoride
Authors: Ahn Ji-Hye , Kim Ji-Woong , Yoon Young-Mi , Lee Nan-Young , Lee Sang-Ho , Jih Myeong-Kwan
Published: November 2020

This study compared the demineralization resistance of teeth treated with silver diamine fluoride (SDF) to that treated with fluoride varnish. A total of 105 healthy bovine incisors were divided into control, fluoride varnish, and SDF groups. The enamel surface density change was then measured by micro-computed tomography (micro-CT) at three depths. The demineralized zone volume was measured on 3D micro-CT images to evaluate the total demineralization rate. The enamel surface morphology was assessed by scanning electron microscope. The enamel density had continuously decreased while demineralization increased in the control and fluoride varnish groups. The enamel density had increased in the SDF group till the 7th day of demineralization treatment and decreased thereafter. However, the decrease in the SDF group was less severe than that in the other groups (p < 0.05). The demineralized enamel volume had increased through treatment and was the highest in the control group, followed by the fluoride varnish and SDF group. The enamel surface morphology was the roughest and most irregular in the control group, followed by the fluoride varnish group and SDF groups.
Management of Molar Incisor Hypomineralisation (MIH): A 1-Year Retrospective Study in a Specialist Secondary Care Centre in the UK
Authors: Humphreys Judith , Albadri Sondos
Published: November 2020

(1) Background: Molar incisor hypomineralisation (MIH) is an enamel defect that affects an estimated 14.2% of children worldwide. Care takes place in primary and secondary care facilities. (2) Aim: To investigate how children with MIH are managed within a specialist centre in the north of England. (3) Method: A retrospective service evaluation within the paediatric dentistry department was registered with the clinical governance unit. Children who attended consultant-led new-patient clinics between 1 January and 31 December 2015 with a diagnosis of MIH were included. The data collected concerned the pre-referral treatment, the history and diagnoses and the treatments completed. (4) Results: Out of 397 records reviewed, 48 (12.1%) had MIH, where 81.3% and 18.8% of patients had severe and mild MIH, respectively. The majority of patients (n = 44 (91.7%)) were referred appropriately. Treatment was completed at the specialist centre for 44 (91.7%) patients. Twenty-five (52.1%) patients had an extraction of one or more first permanent molar teeth. Sixteen patients had the extractions at between 8 and 10 years old and 2 had the extractions later as part of an orthodontic plan. (5) Conclusion: Most children had severe MIH and were referred at an appropriate time to facilitate the consideration of loss of poor prognosis of first permanent molars (FPMs). Most children required specialist management of their MIH.
The Leafless Vanilla Species-Complex from the South-West Indian Ocean Region: A Taxonomic Puzzle and a Model for Orchid Evolution and Conservation Research
Authors: Andriamihaja Cathucia F. , Ramarosandratana Aro V. , Grisoni Michel , Jeannoda Vololoniaina , Besse Pascale
Published: November 2020

The pantropical genus Vanilla is a member of the Orchidaceae family, one of the largest and most diverse families of angiosperms in the world. It originated in America and differentiated in America, Africa, and Asia. About 132 species of Vanilla have now been accepted since the discovery of the genus. Within the Vanilla genus, leaflessness has appeared at least three independent times, in Africa, Asia, and America as an adaptation to drought conditions. The South-West Indian Ocean (SWIO) region, a biodiversity hotspot for orchids, is home to seven leafless species. Chloroplast markers failed to differentiate species within this recent SWIO clade. Morphological traits used for description are very similar between species and do not provide reliable identification. Moreover, some of the species have overlapping flowering periods and geographic distribution in Madagascar, increasing the probability of finding some sympatric species and, therefore, hybrids. Leafless Vanilla species from the SWIO islands are thus an excellent model for understanding the evolution of orchids. For their conservation, and to confirm the identity of these leafless species, an integrated approach with classical taxonomy using a large number of samples, intense fieldwork on biology and ecology, and molecular studies using variable markers is necessary.
Early Onset Ataxia with Comorbid Dystonia: Clinical, Anatomical and Biological Pathway Analysis Expose Shared Pathophysiology
Authors: Sival Deborah A. , Garofalo Martinica , Brandsma Rick , Bokkers Tom A. , van den Berg Marloes , de Koning Tom J. , Tijssen Marina A. J. , Verbeek Dineke S.
Published: November 2020

In degenerative adult onset ataxia (AOA), dystonic comorbidity is attributed to one disease continuum. However, in early adult onset ataxia (EOA), the prevalence and pathogenesis of dystonic comorbidity (EOAD+), are still unclear. In 80 EOA-patients, we determined the EOAD+-prevalence in association with MRI-abnormalities. Subsequently, we explored underlying biological pathways by genetic network and functional enrichment analysis. We checked pathway-outcomes in specific EOAD+-genotypes by comparing results with non-specifically (in-silico-determined) shared genes in up-to-date EOA, AOA and dystonia gene panels (that could concurrently cause ataxia and dystonia). In the majority (65%) of EOA-patients, mild EOAD+-features concurred with extra-cerebellar MRI abnormalities (at pons and/or basal-ganglia and/or thalamus (p = 0.001)). Genetic network and functional enrichment analysis in EOAD+-genotypes indicated an association with organelle- and cellular-component organization (important for energy production and signal transduction). In non-specifically, in-silico-determined shared EOA, AOA and dystonia genes, pathways were enriched for Krebs-cycle and fatty acid/lipid-metabolic processes. In frequently occurring EOAD+-phenotypes, clinical, anatomical and biological pathway analyses reveal shared pathophysiology between ataxia and dystonia, associated with cellular energy metabolism and network signal transduction. Insight in the underlying pathophysiology of heterogeneous EOAD+-phenotype-genotype relationships supports the rationale for testing with complete, up-to-date movement disorder gene lists, instead of single EOA gene-panels.
Integrated Information in the Spiking–Bursting Stochastic Model
Authors: Kanakov Oleg , Gordleeva Susanna , Zaikin Alexey
Published: November 2020

Integrated information has been recently suggested as a possible measure to identify a necessary condition for a system to display conscious features. Recently, we have shown that astrocytes contribute to the generation of integrated information through the complex behavior of neuron–astrocyte networks. Still, it remained unclear which underlying mechanisms governing the complex behavior of a neuron–astrocyte network are essential to generating positive integrated information. This study presents an analytic consideration of this question based on exact and asymptotic expressions for integrated information in terms of exactly known probability distributions for a reduced mathematical model (discrete-time, discrete-state stochastic model) reflecting the main features of the “spiking–bursting” dynamics of a neuron–astrocyte network. The analysis was performed in terms of the empirical “whole minus sum” version of integrated information in comparison to the “decoder based” version. The “whole minus sum” information may change sign, and an interpretation of this transition in terms of “net synergy” is available in the literature. This motivated our particular interest in the sign of the “whole minus sum” information in our analytical considerations. The behaviors of the “whole minus sum” and “decoder based” information measures are found to bear a lot of similarity—they have mutual asymptotic convergence as time-uncorrelated activity increases, and the sign transition of the “whole minus sum” information is associated with a rapid growth in the “decoder based” information. The study aims at creating a theoretical framework for using the spiking–bursting model as an analytically tractable reference point for applying integrated information concepts to systems exhibiting similar bursting behavior. The model can also be of interest as a new discrete-state test bench for different formulations of integrated information.
A Virtual Device for Simulation-Based Fault Injection
Authors: Muñoz-Quijada Maria , Sanz Luis , Guzman-Miranda Hipolito
Published: November 2020

This paper describes the design and implementation of a virtual device to perform simulation-based fault injection campaigns. The virtual device is fully compatible with the same user software that is already being used to perform fault injection campaigns in existing FPGA (Field Programmable Gate Array)-based hardware devices. Multiple instances of the virtual device can be launched in parallel in order to speed-up the fault injection campaigns, without any preexisting limitations on number, such as available license seats, since the virtual device can be compiled with the open-source simulator GHDL. This virtual device also allows one to find bugs in both software and firmware, and to reproduce in simulation, with total visibility of the internal states, corner cases that may have occurred in the real hardware.
Performance Study of Split Ferrite Cores Designed for EMI Suppression on Cables
Authors: Suarez Adrian , Victoria Jorge , Torres Jose , Martinez Pedro A. , Alcarria Antonio , Perez Joaquin , Garcia-Olcina Raimundo , Soret Jesus , Muetsch Steffen , Gerfer Alexander
Published: November 2020

The ideal procedure to start designing an electronic device is to consider the electromagnetic compatibility (EMC) from the beginning. Even so, EMC problems can appear afterward, especially when the designed system is interconnected with external devices. Thereby, electromagnetic interferences (EMIs) could be transmitted to our device from power cables that interconnect it with an external power source or are connected to another system to establish wired communication. The application of an EMI suppressor such as a sleeve core that encircles the cables is a widely used technique to attenuate EM disturbances. This contribution is focused on the characterization of a variation of this cable filtering solution based on openable core clamp or snap ferrites. This component is manufactured by two split parts pressed together by a snap-on mechanism which turns this into a quick, easy to install solution for reducing post-cable assembly EMI problems. The performance of three different materials, including two polycrystalline (MnZn and NiZn) materials and nanocrystalline (NC) solution, are analyzed in terms of effectiveness when the solid sleeve cores are split. The possibility of splitting an NC core implies an innovative technique due to the brittleness of this material. Thus, the results obtained from this research make it possible to evaluate this sample’s effectiveness compared to the polycrystalline ones. This characterization is carried out by the introduction of different gaps between the different split-cores and analyzing their behavior in terms of relative permeability and impedance. The results obtained experimentally are corroborated with the results obtained by a finite element method (FEM) simulation model with the aim of determining the performance of each material when it is used as an openable core clamp.
Patient Monitoring by Abnormal Human Activity Recognition Based on CNN Architecture
Authors: Gul Malik Ali , Yousaf Muhammad Haroon , Nawaz Shah , Ur Rehman Zaka , Kim HyungWon
Published: November 2020

Human action recognition has emerged as a challenging research domain for video understanding and analysis. Subsequently, extensive research has been conducted to achieve the improved performance for recognition of human actions. Human activity recognition has various real time applications, such as patient monitoring in which patients are being monitored among a group of normal people and then identified based on their abnormal activities. Our goal is to render a multi class abnormal action detection in individuals as well as in groups from video sequences to differentiate multiple abnormal human actions. In this paper, You Look only Once (YOLO) network is utilized as a backbone CNN model. For training the CNN model, we constructed a large dataset of patient videos by labeling each frame with a set of patient actions and the patient’s positions. We retrained the back-bone CNN model with 23,040 labeled images of patient’s actions for 32 epochs. Across each frame, the proposed model allocated a unique confidence score and action label for video sequences by finding the recurrent action label. The present study shows that the accuracy of abnormal action recognition is 96.8%. Our proposed approach differentiated abnormal actions with improved F1-Score of 89.2% which is higher than state-of-the-art techniques. The results indicate that the proposed framework can be beneficial to hospitals and elder care homes for patient monitoring.
Evaluation of Clearance to Stop Requirements in A Seismically Isolated Nuclear Power Plant
Authors: An Gyeonghee , Kim Minkyu , Jung Jae-Wook , Mosqueda Gilberto , Marquez Joaquin Fabian
Published: November 2020

Seismically isolated nuclear power plants (NPPs) can provide substantial benefits towards reducing the failure probability of NPPs, especially for beyond design basis earthquake shaking. One risk posed by seismic isolation is the potential for pounding to a stop or moat wall, with currently little guidance provided by design standards on how to address this concern. In this paper, a structural model of an isolated NPP based on the Advanced Power Reactor 1400 MW is enveloped with moat walls and advanced bearing models. The bearing models account for large strain behavior through failure based on full-scale experiments with lead rubber bearings (LRBs). Using these analytical models and a measured ultimate property diagram from LRB failure tests, the range of clearance to the stop considering the performance criteria for the NPP is investigated. Although the analysis results are dependent on the particular models, ground motions, and criteria employed, this research provides an overview of the seismic response and performance criteria of an isolated NPP considering the clearance to the stop.
Thermodynamic Modeling and Performance Analysis of a Combined Power Generation System Based on HT-PEMFC and ORC
Authors: Kang Hyun Sung , Kim Myong-Hwan , Shin Yoon Hyuk
Published: November 2020

Recently, the need for energy-saving and eco-friendly energy systems is increasing as problems such as rapid climate change and air pollution are getting more serious. While research on a power generation system using hydrogen energy-based fuel cells, which rarely generates harmful substances unlike fossil fuels, is being done, a power generation system that combines fuel cells and Organic Rankine Cycle (ORC) is being recognized. In the case of High Temperature Proton Exchange Membrane Fuel Cell (HT-PEMFC) with an operating temperature of approximately 150 to 200 °C, the importance of a thermal management system increases. It also produces the waste heat energy at a relatively high temperature, so it can be used as a heat source for ORC system. In order to achieve this outcome, waste heat must be used on a limited scale within a certain range of the temperature of the stack coolant. Therefore, it is necessary to utilize the waste heat of ORC system reflecting the stack thermal management and to establish and predict an appropriate operating range. By constructing an analytical model of a combined power generation system of HT-PEMFC and ORC systems, this study compares the stack load and power generation performance and efficiency of the system by operating temperature. In the integrated lumped thermal capacity model, the effects of stack operating temperature and current density, which are important factors affecting the performance change of HT-PEMFC and ORC combined cycle power generation, were compared according to operating conditions. In the comparison of the change in power and waste heat generation of the HT-PEMFC stack, it was shown that the rate of change in power and waste heat generation by the stack operating temperature was clearly changed according to the current density. In the case of the ORC system, changes in the thermal efficiency of the ORC system according to the operating temperature of the stack and the environmental temperature (cooling temperature) of the object to which this system is applied were characteristic. This study is expected to contribute to the establishment of an optimal operation strategy and efficient system configuration according to the subjects of the HT-PEMFC and ORC combined power generation system in the future.
Modeling of Limestone Dissolution for Flue Gas Desulfurization with Novel Implications
Authors: De Blasio Cataldo , Salierno Gabriel , Sinatra Donatella , Cassanello Miryan
Published: November 2020

Solid-liquid dissolution is a central step in many industrial applications such as pharmaceutical, process engineering, and pollution control. Accurate mathematical models are proposed to improve reactor design and process operations. Analytical methods are significantly beneficial in the case of iterative methods used within experimental investigations. In the present study, a detailed analytical solution for the general case of solid particles dissolving in multiphase chemical reaction systems is presented. In this model, the authors consider a formulation that considers the particles’ shape factor. The general case presented could be utilized within different problems of multiphase flows. These methods could be extended to different cases within the chemical engineering area. Examples are illustrated here in relation to limestone dissolution taking place within the Wet Flue Gas Desulfurization process, where calcium carbonate is dissolving in an acidic environment. The method is the most common used technology to abate SO2 released by fuel combustion. Limestone dissolution plays a major role in the process. Nevertheless, there is a need for improvements in the optimization of the WFGD process for scale-up purposes. The mathematical model has been tested by comparison with experimental data from several mild acidic dissolution assays of sedimentary and metamorphic limestone. We have found that R2 ⊂ 0.92 ± 0.06 from dozens of experiments. This fact verifies the model qualifications in capturing the main drivers of the system.
Combustible Material Content vs. Fire Properties of Electric Cables
Authors: Kaczorek-Chrobak Katarzyna , Fangrat Jadwiga
Published: November 2020

The fire load of buildings is significantly increased by means of electric cables, usually creating a long combustible base for fire to spread and in this way decreasing the fire safety of buildings. The aim of the study was to evaluate a relationship between the construction of the cables and their fire properties, especially the mass loss influence on other fire properties of cables. Six cables of different core numbers were tested by means of the standard test method EN 50399. Additionally, thermogravimetric analysis and Attenuated Total Reflection—Fourier Transform Infrared analysis were performed on the separate outer sheath, bedding, and core insulations in order to determine the similarity of the materials’ chemical structures. It was found that: (1) the construction of the cable strongly influences the fire behavior due to the creation of a barrier for flame penetration and emission of combustion effluents though inside the closed agglomeration of non-combustible metallic cores (conductors), and the intumescent structures formed from aluminum trihydrate/zinc borate fillers and fire retardants in outer sheath material during the self-sustained combustion process after ignition of cables; (2) the inhomogeneous distribution of non-combustible inorganic fillers or different contents of fillers and flame retardants within the polymer fraction cause an unobvious fire behaviors of cables; and (3) the use of bedding in multicore cable construction results in lower values of combustion parameters (maximum average heat release rate, total heat release, maximum average smoke production rate, total smoke production), e.g., better fire properties of cables.
Operation of a Solid Oxide Fuel Cell Based Power System with Ammonia as a Fuel: Experimental Test and System Design
Authors: Barelli Linda , Bidini Gianni , Cinti Giovanni
Published: November 2020

Ammonia has strong potentialities as sustainable fuel for energy applications. NH3 is carbon free and can be synthetized from renewable energy sources (RES). In Solid Oxide Fuel Cells, NH3 reacts electrochemically thereby avoiding the production of typical combustion pollutants such as NOx. In this study, an ammonia-fueled solid oxide fuel cells (SOFC) system design is proposed and a thermodynamic model is developed to evaluate its performance. A SOFC short stack was operated with NH3 in a wide range of conditions. Experimental results are implemented in the thermodynamic model. Electrical efficiency of 52.1% based on ammonia Lower Heating Value is calculated at a net power density of 0.36 W cmFC−2. The operating conditions of the after burner and of the ammonia decomposition reactor are studied by varying the values of specific parameters. The levelized cost of energy of 0.221 $ kWh−1 was evaluated, as introduced by the International Energy Agency, for a system that operates at nominal conditions and at a reference power output of 100 kW. This supports the feasibility of ammonia-fueled SOFC systems with reference to the carbon free energy market, specifically considering the potential development of green ammonia production.
Species, Climatypes, Climate Change, and Forest Health: A Conversion of Science to Practice for Inland Northwest (USA) Forests
Authors: Rehfeldt Gerald E. , Warwell Marcus V. , Monserud Robert A.
Published: November 2020

Research Highlights: This paper integrates disparate research results pertaining to climate change impacts to 12 co-occurring forest tree species and their climatypes such that management options for the ecosystem as a whole become discernible. Background and Objectives: The ecosystem under analysis is the Thuja-Tsuga forest ecosystem, occupying ca. 121,500 km2 in a largely mountainous setting in the interior northwest, USA. Our goal is to present land management options tied directly to climate-change in a straightforward framework for both the current and future generations. Materials and Methods: By merging synecological and genecological concepts in a climatic framework, we simplify complex interactions in a manner that relates directly to climate change impacts. Species and climatype distributions are redefined in terms of mean annual temperature and elevation of forested landscapes. Results: For each 2 °C increase in temperature, plant associations should shift upwards ca. 400 m, provided precipitation remains at or near contemporary levels, which, for this ecosystem, vary between 300 mm and 1450 mm. Management guidelines are developed for (a) selecting climatypes of the species suited to the climate at the leading edge of the migration front, (b) anticipating decline at the trailing edge, and (c) converting climatypes in areas where species should persist. Conclusions: Our results can provide robust strategies for adapting forest management to the effects of climate change, but their effectiveness is dependent on the implementation of global warming mitigation actions.
A Techno-Economic Perspective on Natural Gas and Its Value Chain
Authors: Egging-Bratseth Ruud
Published: November 2020

We describe the elements and actors in the global natural gas value chains with an emphasis on characteristics relevant for large-scale energy system and market modeling. We give backgrounds on natural gas as a hydrocarbon to provide a rationale and understanding for what functional representations in mathematical programming models aim to represent. Simply taking the most advanced and detailed functional forms for all value chain characteristics and activities will typically result in numerical intractability. One should carefully determine what is needed to address a research question or analyze a business case. Recent advances in mathematical programming do allow solving large models with adequate detail for many types of analysis. We discuss which functional forms and modeling approaches can be appropriate for representing various characteristics in different types of analysis and provide a succinct and general mathematical programming formulation reflecting the optimization problems for different types of actors in the value chain. We provide an implementation for a stylized network using GAMS.
Topographic Thresholds and Soil Preservation along the Southern High Plains Eastern Escarpment, Northwest Texas, USA
Authors: Conley Travis , Hurst Stance , Johnson Eileen
Published: November 2020

The eastern escarpment of the Southern High Plains (USA) is today a semi-arid erosional landscape delineated by canyon breaks and topographic relief. A series of buried soils were identified, described, and sampled at 19 soil profile localities exposed along terraces of the South Fork of the Double Mountain Fork of the Brazos River (South Fork) and two associated tributaries (Spring Creek and Macy 285 drainage). Radiocarbon dating revealed late-Pleistocene to early Holocene (~12,580–9100 14C B.P.), middle-Holocene (~6025–4600 14C B.P.), and late-Holocene (~2000–800 14C B.P.) buried soils. The late-Pleistocene to middle-Holocene soils were preserved only at higher elevations within the upper section of the South Fork and Spring Creek. A topographic position analysis was conducted using GIS to identify and examine the impacts of a soil topographic threshold on the preservation and distribution of buried soils within this geomorphic system. Above the identified ~810 m threshold, lateral migration of channels was constrained. Extensive channel migration below the threshold removed older terraces that were replaced with late-Holocene terraces and associated buried soils. Landscape topography constraints on geomorphic processes and soil formation impacted the preservation of archaeological sites in this semi-arid region.
The Evolution of Covid-19 in Italy after the Spring of 2020: An Unpredicted Summer Respite Followed by a Second Wave
Authors: De Natale Giuseppe , De Natale Lorenzo , Troise Claudia , Marchitelli Vito , Coviello Antonio , Holmberg Karen G. , Somma Renato
Published: November 2020

The coronavirus (COVID-19) pandemic was particularly invasive in Italy during the period between March and late April 2020, then decreased in both the number of infections and in the seriousness of the illness throughout the summer of 2020. In this work, we measure the severity of the disease by the ratio of Intensive Care Units (ICU) spaces occupied by COVID-19 patients and the number of Active Cases (AC) each month from April to October 2020. We also use the ratio of the number of Deaths (D) to the number of Active Cases. What clearly emerges, from rigorous statistical analysis, is a progressive decrease in both ratios until August, indicating progressive mitigation of the disease. This is particularly evident when comparing March–April with July–August; during the summer period the two ratios became roughly 18 times lower. We test such sharp decreases against possible bias in counting active cases and we confirm their statistical significance. We then interpret such evidence in terms of the well-known seasonality of the human immune system and the virus-inactivating effect of stronger UV rays in the summer. Both ratios, however, increased again in October, as ICU/AC began to increase in September 2020. These ratios and the exponential growth of infections in October indicate that the virus—if not contained by strict measures—will lead to unsustainable challenges for the Italian health system in the winter of 2020–2021.
Active Transport to School May Reduce Psychosomatic Symptoms in School-Aged Children: Data from Nine Countries
Authors: Kleszczewska Dorota , Mazur Joanna , Bucksch Jens , Dzielska Anna , Brindley Catherina , Michalska Agnieszka
Published: November 2020

It is widely proven that being physically active and avoiding sedentary behaviour help to improve adolescents’ well-being and keep them in better health in general. We aimed to investigate the relationship between modes of transport to school and subjective complaints among schoolchildren. Analyses were based on the HBSC (Health Behaviour in School-aged Children) surveys conducted in 2017/18 in nine countries (N = 55,607; mean age 13.43 ± 1.64 yrs.). The main outcome showed that health complaints consisted of somatic and psychological complaints. Transport to school was characterized by mode of getting there (walking, biking, or another passive mode). A total of 46.1% of students walked and 7.3% cycled to school; 46.6% commuted by passive means. Biking to school was more frequent in Denmark (37.9%), Norway (26.5%), and Germany (26.6%). The multivariate generalized linear model adjusted for age, gender, country, and school proximity showed that biking to school is protective against reports of health complaints. The beta parameters were equal to −0.498 (p < 0.001) for the general HBSC-SCL index, −0.208 (p < 0.001) for the somatic complaint index, and −0.285 (p < 0.001) for the psychological complaints index. Young people who actively commute to school are less likely to report health complaints, especially psychological symptoms.
A Systematic Review of Methods and Criteria Standard Proposal for the Use of Principal Component Analysis in Team’s Sports Science
Authors: Rojas-Valverde Daniel , Pino-Ortega José , Gómez-Carmona Carlos D. , Rico-González Markel
Published: November 2020

The availability of critical information about training and competition is fundamental on performance. Principal components analysis (PCA) is widely used in sports as a multivariate technique to manage big data from different technological assessments. This systematic review aimed to explore the methods reported and statistical criteria used in team’s sports science and to propose a criteria standard to report PCA in further applications. A systematic electronic search was developed through four electronic databases and a total of 45 studies were included in the review for final analysis. Inclusion criteria: (i) of the studies we looked at, 22.22% performed factorability processes with different retention criteria (r > 0.4–0.7); (ii) 21 studies confirmed sample adequacy using Kaiser-Meyer-Olkim (KMO > 5–8) and 22 reported Bartlett’s sphericity; (iii) factor retention was considered if eigenvalues >1–1.5 (n = 29); (iv) 23 studies reported loading retention (>0.4–0.7); and (v) used VariMax as the rotation method (48.9%). A lack of consistency and serious voids in reporting of essential methodological information was found. Twenty-one items were selected to provide a standard quality criterion to report methods sections when using PCA. These evidence-based criteria will lead to a better understanding and applicability of the results and future study replications.