bluuebunny/crossref_metadata_2025 huggingface dataset:
Factor analysis: psychological and social maturity of personality
Authors: Popovici Adriana
Published: October 2024

The article addresses the topic of psychological and social maturity, highlighting the interdependence between these two essential concepts in the field of psychology. The paper provides a detailed analysis of how these notions are understood and applied in the specialized literature, emphasizing the main indicators of optimal development of psychological and social maturity. Empirically, it presents the results of a study conducted in 2023, which focused on identifying the interconnections between psychological and social maturity in young people during their transition from education to work. This research offers valuable contributions to both the field of psychology and pedagogy, providing a reference framework for understanding the complexity of the maturation process from a psycho-social perspective. The study served as a basis for developing an educational program aimed at promoting the development of indicators associated with achieving optimal psycho-social maturity.
Peculiarities of image formation in ceramics and artistic printing of Tatiana Vatavu
Authors: Spînu Constantin
Published: October 2024

The creative options of Tatiana Vatavu were directed from the beginning – the last decade of the 20th century - and in the first decades of the new millennium, towards the determination and development of her own style, the elaboration of a thematic repertoire that encouraged her initiation and development of an innovative artistic discourse that enriched the art of ceramics and artistic printing in the Republic of Moldova with new aesthetic values. The thematic area reveals, on the one hand, tendencies to capitalize on important conceptual landmarks rooted in the artifacts of popular plastic creation, and on the other hand, it reflects the artist's aspirations directed towards the capitalization of ideas that would facilitate an ascending path in the diversification of the plastic language and its symbolism, and the promotion of its own creative identity. The ceramic works highlight relevant morphological and syntactic experiments, through which the combined form of the pieces promotes original aesthetic values and complex messages, while those in the field of artistic printing and drawing reflect the exceptional ability to operate with the plastic means in order to achieve the compositional integrity of the image and to highlight certain topical messages.
Decoding Genetic Signatures for Identification: A Molecular Investigation Approach in Pakistan via Cytochrome C Oxidase I (COI) Gene Sequencing
Authors: Muhammad Usman  , Sahrish Ghazanfar  , Sana Ashraf  , Asma Iqbal  , Naila Amjad  , Shakeel Ahmad  , Sahrish Naqvi  , Muhammad Khalid  , Ayesha Imtiaz  , Mudassar Maqbool  , Muhammad Imran  , Hassan  Raza Javed  , Sana Shahid
Published: October 2024

DNA barcoding is an efficient and rapid approach to the identification of species. A standard genetic marker is used to barcode the sequence of unidentified species. So, mitochondrial cytochrome c oxidase I (COI) genetic marker is mostly used for species molecular identification. Therefore, molecular identification and phylogeographic relationship of Cirrhinus reba (C. reba) were carried out in the present study. In the present study, we propose the barcoding analysis of the mitochondrial cytochrome c oxidase I (COI) gene of freshwater fish as different sequences were obtained from the sequencer and found (all < 500) base pairs and successfully barcode with mitochondrial COI genetic marker for identification. BLAST analysis provides 100% identity match with reference sequences of GenBank database and confirmed the species as C. reba as the length of the sequence is found 496 base pairs. The present study successfully reported DNA barcoding for genetic diversity and identification contributing to covering sufficient information about molecular analysis to identify unknown species the best of our knowledge this is the first study reporting a genetic tool for identification of the commercial food fish of Pakistan. Moreover, DNA barcoding can play a very significant role in molecular identification and inference of relationships in diverse freshwater ecosystem.
An Analysis of the Physical Environment and Distribution of Lifelong Education Facilities: A Case Study of Gongju City
Authors:   The Korean Society for Lifelong Education, Park Jisuk , Min Kyunghun
Published: October 2024

This study investigates the physical environment of lifelong education facilities crucial for the revitalization of lifelong education. By analyzing the spatial characteristics of these facilities, key issues related to their physical environment are identified. Focusing on Gongju City, regulations and previous research on lifelong and other educational facilities are examined. The distribution and total area of 75 lifelong education facilities in Gongju City as of 2021 are analyzed in relation to the demographic characteristics and population size.
The analysis reveals that the number and total area of lifelong education facilities do not proportionally align with population size. Despite the high number of facilities, many do not meet the minimum space requirements, and several regions lack even a single facility per legal district. Two critical points are discussed based on these findings: first, improving accessibility to lifelong education facilities to ensure that residents can easily participate in lifelong education; second, establishing a minimum standard of area to provide a safe and conducive learning environment. The study emphasizes the need for regular statistical monitoring of facility numbers and spatial conditions to promote the philosophy of lifelong education and achieve spatial equity.
Experiences of Higher Education and the Meaning of 'University' for Women who Crossed Boundaries: Focusing on the Case of North Korean Defector Women in the Two Koreas’ Higher education
Authors:   The Korean Society for Lifelong Education, Nam Youjin , Kim You-Yeon , Kang Hee Young
Published: October 2024

The purpose of this study is to examine the higher education experiences of North Korean defector women who have crossed both national borders and the boundary between life and death, focusing on their academic journeys in North and South Korea and the significance of their achievements in the South. This research involved a case study of three women who pursued higher education in both countries. For these women, re-entering university in South Korea was not only a proactive choice but also a reaction against their irreversible educational experiences in North Korea. It served as a defensive strategy against the structures of discrimination they encountered in South Korean society and provided a period of deferred assimilation, allowing them to adopt an identity as ‘learners’ in pursuit of their academic aspirations. Although they had successfully escaped the visible oppression of the North Korean regime, they found themselves in a new, invisible but equally powerful structure under the principles of capitalism, where they felt the need to continuously prove and equip themselves. In this context, returning to university was a deliberate choice to integrate into South Korean society, fully aware of and accepting the social emphasis on educational attainment and credentials. Through this process, they sought to secure the qualifications necessary for social acceptance and recognition in their new country.
Artificial Intelligence and Data Concerns for Government Sector Undertakings
Authors: Mayank Chhatwal
Published: October 2024

The integration of Artificial Intelligence (AI) within government sector undertakings (PSUs) represents a critical step toward achieving enhanced operational efficiency, improved service delivery, and more informed decision-making processes. However, this transformative potential is accompanied by significant concerns, particularly around data privacy, security, governance, and ethical issues. This paper seeks to explore the nuanced relationship between AI and data concerns in PSUs, evaluating the advantages, challenges, and best practices for managing these technologies responsibly. In doing so, it highlights strategies for balancing innovation with responsible data governance to ensure that AI is implemented effectively, ethically, and securely in the public sector.
畜牧业来源的抗生素耐药大肠杆菌研究进展
Authors: 李 嘉 , 孙 世广
Published: October 2024

大肠杆菌是动物和人类胃肠道和肠道外疾病的最常见原因之一。由于抗生素的过度使用和误用，近年来抗生素耐药大肠杆菌在全球的流行率迅速上升；特别是来自农场动物相关来源的抗生素耐药大肠杆菌及其抗生素耐药基因 (ARGs) 正在成为全球关注的问题，并且在临床上对人类和动物的健康都具有负面的影响。本综述的目的是探讨来自畜牧业、废物处理和水生环境的抗生素耐药大肠杆菌的流行趋势。重点介绍了抗生素的消毒方法和可能的替代方法。同时发现来自食用动物、产品和动物粪便的过敏性大肠杆菌的流行率正在以惊人的速度增加，但在废物处理厂却有所减少。紫外线 (UV) 处理、表面等离子体氧化和生物炭通常用于有效消除抗生素耐药大肠杆菌。一些益生菌、植物提取物和抗菌肽作为抗生素的有希望的替代品正在引起人们的更大关注。目前的研究表明，来自畜牧业的抗生素耐药大肠杆菌普遍存在，并对全球公共卫生构成严重威胁。这一综述为进一步研究、开发和应用新的策略来减少农场动物源性大肠杆菌的抗生素耐药性提供了新的思路。
抗生素抗性基因的传播机制及对策
Authors: 韩 爱萍
Published: October 2024

抗生素的出现极大地便利了生活，但由于滥用抗生素，全球抗药性的扩散对公共卫生构成了严重威胁。用于治疗和预防的抗生素正在全球范围内得到越来越广泛的使用。耐药菌株的数量在增加，越来越多的耐药基因正在出现。这将给自然环境、人类生产和生活带来更大的潜在危害。本文简要介绍了污水处理中抗生素抗性基因(ARGs) 传播的现状。此外，总结了基因编辑、全基因组测序 (WGS) 和人工智能 (AI) 在降低或阻止抗生素抗性扩散方面的应用，并探讨和展望了几种污水处理过程的工程可行性。这为找到能减少抗微生物药物抗性基因的出现，从根源上抑制抗生素抗性基因的传播，并最大限度地维护生活环境和保护公共健康安全的方法提供了参考。
食用动物细菌抗生素耐药性研究进展
Authors: 李 嘉 , 韩 爱萍
Published: October 2024

在食用动物中过度使用抗生素的现象在世界范围内的广泛存在，导致了细菌耐药性问题日益严重。食用动物中的耐抗生素细菌 (ARB) 和耐抗生素基因 (ARGs) 目前被认为是新兴污染物，对全球公共卫生构成严重威胁。本文首次综述了食用动物养殖场、粪便和废水中 ARB 和 ARGs 的现状，同时还强调了对公共卫生的潜在风险，以及抗击细菌耐药性的战略 (包括新技术、替代品和管理)。本综述可为进一步研究、开发和应用新型抗菌药物，减少食用动物养殖场抗生素耐药性的不良影响提供参考。
基于分子模拟技术筛选南美白对虾胶原蛋白中的抗氧化肽
Authors: 邹 天畅
Published: October 2024

本研究以生物信息学技术为基础，利用计算机模拟酶解、相关活性预测与评价、药物代谢动力学及分子模拟技术对南美白对虾胶原蛋白抗氧化肽进行筛选。通过 BIOPEP-UWM 模拟酶解、Peptide Ranker 评分得到具有生物活性的小分子肽，同时采用 ToxinPred、Innovagen 及 Expasy 进一步分析肽段的理化性质，并通过药物代谢动力学 ADMET 分析对肽段进行筛选，得到 2 条无毒、无致敏性、无致突变性、无致癌性及水溶性良好的小分子肽，采用分子对接技术将 AWW、HL 两种抗氧化肽与超氧化物歧化酶 ( superoxide dismutase，SOD) 结合，对其最优复合物进行构象分析。结果显示，AWW、HL 抗氧化肽可在人体中较好地发挥抗氧化活性，本方法为天然食品源抗氧化肽的高效、快速、低成本筛选提供了新思路。
基于网络药理学和分子对接探讨甘草和酸枣仁对入睡困难型 失眠的作用机制
Authors: 任 翰迟
Published: October 2024

本文基于网络药理学和分子对接探讨甘草和酸枣仁对入睡困难型失眠的作用机制。利用 TCMSP 数据库对甘草和酸枣仁的潜在活性成分及其相关靶点进行筛选；利用 GeneCards、TTD 、OMIM 数据库筛选睡眠障碍、入睡困难和失眠相关靶点，并对其取交集，获得疾病相交靶点；利用 R 语言绘制活性成分作用靶点和疾病相交靶点 Venn 图，获得中药活性成分-疾病共有靶点；采用 Cytoscape 绘制“中药-活性成分-疾病-共有靶点”网络，向 STRING 数据库中导入共有靶点获得 PPI 网络关系，利用 Cytoscape 分析关键作用靶点；利用 DAVID 数据库和 R 进行 GO 功能及 KEGG 通路富集分析；对核心成分与关键靶点进行分子对接验证。最终获得甘草和酸枣仁活性成分共 100 个，相关靶点 184 个，治疗入睡困难型失眠潜在作用靶点 50 个，涉及 336 个生物过程、39个细胞组分、54 个分子功能及 128 条信号通路。筛选得到山奈酚、维斯体素、柚皮素、7-甲氧基-2-甲基异黄酮等核心活性成分；TNF、TP53、IL6、AKT1、IL1B 等核心靶点以及脂质与动脉粥样硬化、癌症的发病途径、流体剪切应力与动脉粥样硬化等多种信号通路。本文通过网络药理学和分子对接探讨甘草和酸枣仁对入睡困难型失眠的作用机制，为进一步研究提供参考。
基于GPS的堆叠串行LSTM组合神经网络目标跟踪方法
Authors: 金 学波 , 刘 嵩政
Published: October 2024

机动目标轨迹估计广泛应用于无人驾驶、拦截导弹等领域。由于机动目标的运动特性的不确定性、传感器精度低的问题，轨迹估计一直是一个开放研究问题和一项有挑战性的工作。本文提出了目标运动特性不确情况下，一种基于深度 LSTM 神经网络的轨迹估计方法。该网络有两个具有堆叠串行关系的 LSTM 网络组成，其中，一个 LSTM 网络用于预测运动状态，另一个网络用于更新状态。与经典的基于机动模型的 Kalman 滤波器相比，本文的方法基于网络学习、无需对运动特性和传感器特性进行建模。实验结果表明，该方法可以在目标运动具有未知和不确定性的情况下，有效提升轨迹的估计性能。
基于机器学习和深度学习的蛋白质结构预测研究进展
Authors: 崔 佳轩
Published: October 2024

蛋白质结构预测是生物信息学领域的一个核心问题，对于理解蛋白质功能、药物设计以及疾病研究具有重要意义。传统的蛋白质结构预测方法受限于计算复杂度和预测精度。近年来，随着机器学习和深度学习技术的快速发展，这些先进的方法被广泛应用于蛋白质结构预测中，显著提高了预测的准确性和效率。本文首先介绍了蛋白质结构预测的背景和重要性，然后详细阐述了机器学习和深度学习在蛋白质结构预测中的应用，包括常用的算法、模型架构以及优化策略。最后，本文展望了基于机器学习和深度学习的蛋白质结构预测在未来的发展方向和潜在挑战，为相关领域的研究者提供了有价值的参考。
基于拮抗特性模型的夜视微光图像与红外图像彩色融合
Authors: 曹 欣然 , 马 慧鋆
Published: October 2024

融合可以有效地利用可见光图像的色彩信息得到较好的可视效果，又可以充分利用红外图像获得人眼无法观察到的红外信息，具有广阔的应用前景。论文首先采用拮抗特性模型中的中心-周边对抗网络对红外与微光图像进行增强，利用区域生长方法对增强后红外图像进行分割，根据分割后各区域亮度得到目标图像。在融合阶段加入两种融合运算：采用选择运算将目标图像信息融合到增强后微光背景中作为亮度通道的输入；利用拮抗特性模型将经采用区域生长法得到红外图像和增强后的微光图像进行融合，作为饱和度通道的输入。同时，直接将增强的微光图像送入调色通道, 作为彩色融合图像的背景进行调色，最后通过彩色重映射并加以显示。实验结果获得的图像具有较好的目标指示特性，色彩更适合人眼观察，有利于提高对目标情景的感知能力。
基于机器学习和深度学习的抗菌肽预测研究进展
Authors: 耿 浩宸
Published: October 2024

随着抗生素耐药性问题的日益严峻，全球对新型药物的需求急剧增加。抗菌肽，作为一种具有广谱抗菌活性的天然肽类物质，展现出对抗耐药性细菌的潜力。然而，传统的抗菌肽发现方法耗时耗力且效率低下，难以满足迅速发展的医疗需求。近年来，机器学习和深度学习技术在生物信息学和序列分析中的应用为抗菌肽的高效预测和设计提供了新的解决方案。本文综述了机器学习和深度学习在抗菌肽预测中的应用，从抗生素耐药性问题引出抗菌肽的重要性，介绍了抗菌肽预测的挑战，以及基于机器学习和深度学习的预测模型和性能评估。尽管面临诸多挑战，二者在抗菌肽研究中的应用仍具有巨大潜力，有望为解决抗生素耐药性问题提供新的策略。
机器学习模型在心血管疾病中的应用
Authors: 蒋 子悠
Published: October 2024

随着当今社会带给人们的高强度工作生活压力,心血管疾病问题的日益严峻，发病率逐年增加,全球对此类疾病的关注与日俱增。传统的预测方法虽有一定预测能力,但是特异性较低，而机器学习和深度学习技术在为心血管疾病的高效预测和设计提供了新的解决方案。本文综述了机器学习和深度学习在心血管疾病预测中的应用，从心血管疾病问题现状引出对其预测的重要性，介绍了其遭遇的挑战，以及预测模型的优势性能评估。尽管面临诸多挑战，机器学习模型在预测心血管疾病研究中的应用仍具有巨大潜力，有望为降低心血管疾病发病率提供新的支持策略。
结合注意力机制和LSTM的参数自适应无模型状态估计
Authors: 陈 伟 , 金 学波 , 马 慧鋆 , 曹 欣然
Published: October 2024

机动目标跟踪广泛地应用于无人车的自动驾驶跟踪领域。在实际应用中，系统噪声协方差很难获得准确值。传统的Kalman滤波器在系统噪声的协方差未知情况下，跟踪性能会下降。为了解决由于实际目标运动复杂、测量传感器噪声特性很难准确建模的困难，本文提出了一种基于注意力参数学习模块的自适应KF算法的状态估计方法：将Transformer的编码器和长短时记忆网络(LSTM)相结合，本文设计了注意力学习模块。通过离线对测量数据进行学习，获得了系统的运动特性，无需进行系统动力学和测量特性建模。进而，基于注意力学习模块的输出，利用期望最大化(EM)算法在线估计系统模型参数，并使用Kalman滤波器获得状态估计。本文使用GPS轨迹路径数据集进行验证，实验结果证明了本文提出的无模型状态估计方法的估计精度优于其他模型，为利用深度学习网络进行轨迹跟踪提供了一种有效方法。
EDUKASI PENGOLAHAN NUGGET IKAN LELE SEBAGAI PRODUK UNGGULAN MASYARAKAT DALAM PENCEGAHAN STUNTING
Authors: Susi Sustiyah , Eunike Wulansari Angely , Ambarita Tresia Ayu Lestari Elipenta , Gantiku Aria
Published: October 2024

ABSTRAK
Stunting dapat dipengaruhi oleh beberapa faktor, yaitu tingkat pendidikan orang tua, status sosial dan ekonomi rumah tangga, serta minimnya penyuluhan tentang stunting dan akses layanan kesehatan. Berdasarkan data Survei Kesehatan Indonesia, pada tahun 2023, Kabupaten Kapuas mencatat angka prevalensi stunting sebesar 16,2%, termasuk di Kecamatan Kapuas Hilir khususnya di Desa Saka Batur. Penurunan angka stunting juga merupakan salah satu prioritas pemerintah Kabupaten Kapuas karena akan berdampak positif bagi kualitas perkembangan masyarakat. Oleh karena itu, Kuliah Kerja Nyata (KKN) di Desa Saka Batur bertujuan untuk memberikan edukasi sosialisasi dan pendampingan pentingnya pencegahan stunting bagi ibu hamil dan balita melalui program kerja Pengolahan Nugget Ikan Lele sebagai produk unggulan ketahanan pangan. Metode yang digunakan adalah sosialisasi melalui penyuluhan pentingnya pengetahuan, pencegahan, dan dampak stunting, serta pendampingan pembuatan nugget ikan lele. Kegiatan ini diikuti oleh 32 orang dan mendapatkan respon positif oleh masyarakat karena ikan lele diternak oleh kelompok masyarakat setempat dan merupakan program unggulan, sehingga keberlanjutan produk nugget ini dapat menjadi salah satu pilihan dalam memenuhi kebutuhan gizi dan menjadi aset untuk meningkatkan pendapatan masyarakat Desa Saka Batur.
Kata Kunci: stunting, nugget ikan lele.
Attitude of Teachers Towards the Use of LMS for Teaching and Learning in Secondary Schools in Delta State
Authors: Ehighae Iyayi Innocent , Okoh Iyeke Patrick
Published: October 2024

This research investigated teachers' perspectives on utilizing Learning Management Systems (LMS) for educational purposes in secondary schools in Delta State. The study was guided by one research question and a null hypothesis, employing a descriptive ex-post facto research design. The total population of the study consisted of 10,764 secondary school teachers in Delta State, with a sample size of 370 teachers selected using proportionate stratified and convenience sampling techniques. Data collection was done through a validated questionnaire endorsed by experts in Guidance and Counselling and Measurement and Evaluation fields. The instrument demonstrated high reliability with a Cronbach alpha coefficient of 0.84. The research question was addressed using mean and standard deviation analysis, while the hypothesis was tested using an independent samples t-test at a significance level of 0.05. Statistical analysis was conducted using the Statistical Package for Social Sciences (SPSS) version 26. Results indicated that teachers exhibited a positive attitude towards LMS use in teaching, and there was no significant difference in attitude between male and female teachers in Delta State's secondary schools. The study recommended that more training and support should be provided to teachers on how to use LMS effectively.
A qualitative assessment of behavioral interview method among anesthesiology residency applicants
Authors: Ramachandran Sujatha , Vick Angela , Nair Singh , Koushik Sarang , Stilli Ludovica , Slinchenkova Kateryna , Viswanath Omar , Gritsenko Karina , Shaparin Naum
Published: October 2024

Background

The objective of residency recruitment is to select the most appropriate candidate. While cognitive skills are identified before an interview and can be measured objectively, non-cognitive skills can be harder to discern. These non-cognitive skills though are a good predictors of future residency performance. A structured behavioral interview is better at identifying noncognitive skills compared to a traditional interview.

Objective

Compare the noncognitive traits identified in the interviews with those identified in resident evaluations

Methods

Using the semi-annual evaluations 6 residents were split between satisfactory group and excellent group. Behavioral-based interviews and traditional unstructured interviews conducted on the same individual were compared and the results of the interview were compared to the semi-annual and annual evaluations submitted by the teaching faculty and the program directors. The interviews were analyzed for non-cognitive skills.

Results

Qualitative analysis of behavioral interview narratives and the narrative part of the semiannual evaluations independently identified the non-cognitive characteristics of adaptability, decisiveness, time management, judgment, and the ability to work in a team. It also identified other essential non-cognitive skills necessary for an anesthesiologist, such as ability to prioritize, study techniques, ability to destress.

Conclusion

The noncognitive traits found in the excellent group response to the structured interview match those found in the semi-annual evaluations. In this case individuals who are suited to the field of anesthesiology are adaptable, decisive, team-players with excellent judgment.
The Effect of Consumer Trust and Service Quality on Shopee Users Online Purchase Decisions
Authors: Harefa Kelly , Gea Elhan , Mendrofa Yupiter , Bate’e Maria Magdalena
Published: October 2024

This research is motivated by the development of the use of digital marketing in Indonesia, especially in the Nias Islands, which is currently running quite rapidly, which has directly given rise to new competition, this requires business actors to be more creative and innovative regarding the marketing changes that are currently occurring. This research aims to determine the influence of consumer trust and service quality on online purchasing decisions of Shopee users among students at the Faculty of Economics, Unversitas Nias, North Sumatera, Indonesia. This research is quantitative research with the research object at the Faculty of Economics, Unversitas Nias, North Sumatera, Indonesia. Data sources are taken from documentation, questionnaire results and observation results. Based on the results of the written analysis and discussion regarding the influence of Consumer Trust and Service Quality on Purchasing Decisions on the Shopee application, it can be concluded that Consumer Trust has a significant influence on Purchasing Decisions on the Shopee application which can be seen from the results of the t-test where Consumer Trust is 4,731 which is greater than t-estimated 2,645 and Service Quality with a t-value of 3,578 which is greater than t-estimated 2,645 and so H2 is accepted. Consumer Trust and Service Quality on Shopee Application Purchase Decisions. This can be proven by the statistical results of F-calculated of 19.008 which is greater than F-estimated of 3.12.
Implementation of Islamic Religious Education Courses at the Center for the Implementation of Personality Formation Courses (PP-MPK) Universitas Sriwijaya, Indonesia
Authors: Safrina Sri
Published: October 2024

Islamic religious education has an important role in shaping the character and morals of students in higher education. The implementation of religious education aims to create a generation that is not only intellectually intelligent, but also has strong moral and spiritual integrity. In Indonesia, the implementation of religious education is strengthened by Law of the Republic of Indonesia Number 12 of 2012 concerning Higher Education. The method in this research uses qualitative methods with content analysis techniques. This student character formation course aims to instill noble values and build strong personalities in students. The implementation of learning material is carried out face-to-face in lecture classes and through e-learning. Islamic Religious Education at PP-MPK Sriwijaya University is a mandatory course which aims to equip students with a broad knowledge base, develop critical thinking skills, and shape student character. This course covers various topics related to Islamic teachings and is implemented through face-to-face, virtual face-to-face and via e-learning methods. The implementation of Islamic religious lectures is not only carried out in the classroom but is also carried out at the Al Ghazali Mosque on the Palembang and Indralaya campuses. In addition to promoting activities at the campus mosque, this activity aims to put into practice the learning of the theory that has been obtained in the classroom, so that students can later put it into practice. learning outcomes into the real world.
Analysis of biological activities of Aloe vera gel and extract used as the potential use in natural food additives
Authors: Yörük Nuray Gamze
Published: October 2024

El propósito de este estudio es evaluar las propiedades antimicrobianas del gel de Aloe vera (AVG) y el extracto de Aloe vera (AVE). En el contexto de la seguridad alimentaria, el enfoque principal ha sido el uso potencial de estos productos naturales como conservantes de alimentos y sus efectos a nivel microbiano. Como parte del estudio, se prepararon AVG y AVE en diferentes concentraciones (1, 2, 3, 4 y 5% p/v). Los microorganismos utilizados en las pruebas incluyeron Salmonella spp., Staphylococcus aureus, Escherichia coli, Bacillus subtilis subsp. spizizenii, Candida albicans y Aspergillus niger. Los análisis microbiológicos se realizaron de acuerdo con las normas ISO y las cargas microbianas se evaluaron en diferentes diluciones. El análisis estadístico de los datos se realizó mediante la prueba de rangos con signos de Wilcoxon, la prueba no paramétrica de Friedman y el ANOVA bidireccional. Se descubrió que ambas formas de AVG y AVE eran efectivas contra ciertas bacterias y hongos probados. Específicamente, la forma de gel de AVG mostró efectividad contra B. subtilis y E. coli, mientras que la forma de extracto fue ineficaz contra estos microorganismos. Los análisis estadísticos indicaron que el tiempo es un factor importante en la eficacia antimicrobiana de AVG y AVE. El estudio presentó hallazgos que respaldan el uso potencial de AVG y AVE como conservantes de alimentos.
Lynxacarus radovskyi en un felino doméstico en la ciudad de Maracaibo, edo. Zulia, Venezuela. Caso clínico
Authors: Prato–Silva Gustavo Adolfo , Parra–Parra Derexandra Verónica
Published: October 2024

Se reporta el caso de un felino doméstico que llega a consulta a la Policlínica Veterinaria de la Universidad del Zulia, por presentar historial de urolitiasis con posible futura programación a cirugía (Cistotomía). El paciente no presentaba sintomatología clínica asociativa a presencia de ácaros. El médico tratante al realizar la exploración física del paciente observa puntos blancos sobre las áreas de pelaje de color negro del felino, llamando su atención, por lo que procedió a realizar exámenes complementarios para poder llegar a un diagnóstico. Por medio de un tricograma y una citología de piel, mediante cinta adhesiva se encontraron huevos y ácaros de la especie Lynxacarus radovskyi en gran cantidad. Este ácaro de la piel en felinos es observado en varios países; presentándose su primera descripción en 1974, por Tenório, en el Hawái, y hay informes en algunos países, como: Australia, Brasil, India y Ecuador. Actualmente no existe un reporte del mismo en la ciudad de Maracaibo, estado Zulia.
SPECIAL ISSUE: The Effect of Perceived Racial Discrimination in African Americans on HRV
Authors: Gustaveson Cody , Lackey Nicholas S. , Baez Katelyn F. , Chintalapalli Sharmista , Maxwell Naomi , Gevirtz Richard N.
Published: October 2024

Health disparities among African Americans have been reported for decades. This is especially true for cardiovascular disease (CVD) even when compared with other minority groups in America. Such disparities have been tied to perceived discrimination. A previous study found that perceived racism accounted for a substantial percentage of the variance in resting heart rate variability (HRV), an independent biomarker of cardiac health. The present study attempts to replicate such findings. This study includes 57 healthy African American individuals who met inclusion criteria. Participants were given the Perceived Ethnic Discrimination Questionnaire–Community Version (PEDQ-CV) and the Perceived Racism Scale (PRS) and had their resting HRV and blood pressure measured. After accounting for breathing rate and age, the lifetime score on the PRS uniquely accounted for up to 45% of the variability of HRV metrics. The PEDQ-CV was not found to be a statistically significant predictor of HRV. Within this sample, blood pressure was not significantly predicted by either scale. The findings suggest that lifetime perceived racism may directly affect HRV indices, which may indicate an increased risk for CVD. Further research should continue to investigate this association and potential avenues for related intervention.
Metin Temelli İşlevsel Dil Bilgisi Öğretiminde Oyunların Rolü: Bir Eylem Araştırması
Authors: Arslan Sevtap , Göçer Ali
Published: October 2024

Dil eğitimi, öğrencilerin dil becerilerini geliştirmeleri için kritik bir alandır. Özellikle Türkçe eğitiminde, dilin yapısal ve işlevsel özelliklerini öğrencilere etkili bir şekilde aktarabilmek önemlidir. Metin temelli dil bilgisi öğretimi, dilin gerçek yaşamdaki kullanımını vurgulayarak, dilin sadece kurallardan ibaret olmadığını, aynı zamanda bir iletişim aracı olduğunu belirtir. Bu yaklaşımla, öğrencilerin dili işlevsel bir şeklilde kullanabilmelerini amaçlanır. Oyunlar, özellikle dil eğitiminde, öğrencilerin dil becerilerini geliştirmelerine yardımcı olabilecek etkili bir araç olarak kabul edilmektedir. Oyunlar, öğrencilere dilin gerçek yaşamdaki kullanımını deneyimleme fırsatı sunar, motivasyonlarını artırır ve dil öğrenme sürecini daha eğlenceli ve etkileşimli kılar. Bu çalışma, metin temelli işlevsel dil bilgisi öğretiminde oyunların rolünü incelemeyi amaçlamaktadır. Eylem araştırması yöntemiyle metin temelli işlevsel dil bilgisi öğretimi çalışmalarında oyunların; dil bilgisi öğretimi üzerindeki etkisi, öğrenci motivasyonu, öğrenme süreci ve dil becerilerinin gelişimine olan katkısı detaylı bir şekilde ele alınmıştır. Metin temelli işlevsel dil bilgisi öğretiminde kullanılan oyunların, öğrencilerin motivasyonunu artırarak dili keşfetmelerini sağlarken kalıcı öğrenme ve üst düzey düşünme becerilerinin gelişimine katkı sunduğu gözlemlenmiştir. Bu yöntemin, dil bilgisi öğrenimini eğlenceli ve etkili hale getirerek öğrencilerin akademik başarısını ve bilgilerin uzun süre akılda kalmasını desteklemede önemli bir rol oynayabileceği görülmüştür.
Examinatıon of Assessment and Evaluation Elements in 5th, 6th and 7th Grade Social Studies Middle School Textbooks
Authors: Çelik Çetinkaya Şeymanur , Oruç Şahin
Published: October 2024

Textbooks are the most fundamental educational materials. For these materials to be effectively used, they need to be relevant to the era we live in. In this context, since 2004, the content of textbooks in Turkey has been prepared within the framework of constructivist education, aiming to enhance students’ cognitive, affective, and psychomotor skills. This study examines the assessment and evaluation elements within Social Studies textbooks to determine their alignment with constructivist education and the specific skills they target for students. The research analyzes assessment components found in six different textbooks approved by the Ministry of National Education (MEB). Within these textbooks, the assessment elements related to seven learning approaches—such as preparatory questions, in-text questions, activities, end-of-text evaluations, self-assessment, peer assessment, concept maps, end-of-unit assessment questions, and group self-assessment—are classified and studied from a constructivist perspective. Using a qualitative research design, document analysis is employed to identify assessment elements and link them to skills consistent with constructivist education. Finally, a comparative evaluation reveals differences between textbooks at different educational levels, contributing to the literature on the relationship between assessment elements and constructivist education in Social Studies textbooks.
İlkokul Matematik Öğretiminde Farklılaştırma Örneği Olarak Resfebenin Kullanımı
Authors: Doğan Adem , Avcıoğlu Aylin
Published: October 2024

Okullarımızda farklı zekâ alanlarına sahip öğrencilerin olması ve teknolojinin çok hızlı ilerlemesi nedeniyle öğretmenlerin derslerde farklılaştırılmış öğretim stratejilerini uygulamaları gerekmektedir. Bu durum öğretmenlerin, farklı materyal kullanma ihtiyacını da doğurmuştur. Bu nedenle, öğretimde içerik farklılaştırması özellikle önemlidir. Bu araştırmanın temel amacı; ilkokul matematik dersi öğretim programında yer alan “Geometrik Cisimler ve Şekiller” ünitesinden seçilen kazanımlarla, içerik farklılaştırılması yapılarak matematik dersinde, bu ünitenin kavramlarının resfebe yöntemiyle oluşturulması ve resfebenin çocukların hayatlarındaki matematiğe olan etkisini incelemektir. Araştırma, 2021-2022 eğitim-öğretim yılında Kahramanmaraş ilinde bir devlet ilkokulunda, 4. sınıf öğrencilerden oluşan toplam 50 öğrenci ile gerçekleştirilmiştir. Araştırmada verilerin toplanması için araştırma yöntemlerinden karma yöntem kullanılmıştır. “Geometrik Cisimler ve Şekiller” ünitesinde farklılaştırılmış öğretim yapılarak bu ünitenin kavramlarına resfebe uygulanmış ve uygulama öncesi ve sonrası yapılan sınavlardan elde edilen veriler karşılaştırılmıştır. Uygulama sonrasında yaptırılan resfebe etkinliğine ilişkin düşüncelerini kaydetmek için bazı öğrencilerle görüşme yapılmıştır. Elde edilen araştırma bulgularında, 4. sınıf öğrencilerine yönelik hazırlanan ve uygulanan farklılaştırılmış matematik öğretimde kullanılan resfebe etkinliklerinin, öğrencilerin matematik dersine ve üniteye olan ilgilerinin olumlu yönde değiştiği, öğrenmeyi daha kalıcı ve etkili hale getirdiği, öğrencileri yaratıcı düşünmeye sevk ettiği ve son olarak kavram öğretiminde etkili olduğu görülmüştür.
Investigation of Higher Education Students' Computational Thinking Skill Levels
Authors: Şahin Kölemen Cansu
Published: October 2024

Computational thinking skill is a skill that has its origins in ancient times but has gained importance today. The competences provided to individuals by computational thinking skills are also of great importance for the education system. Therefore, it is important for students to acquire and develop these skills in order to adapt to the requirements of the modern world. Based on this, in this study, the level of information processing thinking skills of higher education students was examined and the level of this skill was investigated in line with different variables. 'Computational Thinking' scale was used as a data collection tool in the study. Cronbach Alpha internal consistency coefficient of the scale. 96 was calculated as. Demographic characteristics such as gender, department, class and education level were taken into consideration. Quantitative research method was used in the study. The research was conducted with 298 participants studying in higher education. In the analysis of the data, independent t-test and ANOVA analyses were applied to determine the score differences between the groups. As a result of the study, higher education students were found to have high levels of computational thinking skills. Gender was found to be effective on computational thinking skills. As the level of education increased, it was determined that computational thinking skills increased. It was seen that the education given in different departments had an effect on computational thinking skills. Finally, it was found that there were significant changes in students' computational thinking skills as their grade level increased.
Psychometric Properties of Turkish Versions of the Non-Attachment Scale Short Form
Authors: Türk Nuri , Batmaz Hasan
Published: October 2024

This study aimed to examine the psychometric properties of the Non-Attachment Scale Short Form in a Turkish sample. With the participation of 244 adults over 18 years of age, the Short Form of the Nonattachment Scale, the Resilience Scale and the Ontological Addiction Scale were used as data collection tools. Cronbach's alpha and McDonald's omega coefficient were used for the reliability of the Non-Attachment Scale Short Form. According to the results of the analyses, the internal consistency coefficient and McDonald's value were found to be .77 and .78, respectively. Exploratory Factor Analysis (EFA) and Confirmatory Factor Analysis (CFA) were used to test the construct validity of the scale. The results of the analyses showed that the model fit and Kaiser-Meyer-Olkin (KMO) values were at an acceptable level. Item factor loadings ranged between .40 and .67 and the scale was found to have a single factor structure. The statistically significant difference between the 27% lower and upper groups among the participants showed that the item discrimination index of the scale was at a good level. According to the correlation findings conducted to test the criterion validity of the scale, non-attachment was found to have positive significant relationships with resilience (r = .60) and negative significant relationships with ontological dependence (r = -.39). As a result, adaptation of the Short Form of the Non-Attachment Scale can be said to be a valid and reliable measurement tool.
The Effect of Historical Places Through Virtual Museums on Students' Academic Achievement And Attitudes Towards The Course In Social Sciences Course Concept Teaching
Authors: Eren Rahmet , Oruç Şahin
Published: October 2024

This research, 7. the classroom social studies course was conducted in order to determine the effect of historical sites on students' academic achievements and attitudes towards the course through virtual museums in concept teaching. In line with the aim, 20 concepts included in the social studies curriculum were selected. A 20-question academic achievement test was prepared and applied to be applied to students in relation to these concepts. In addition, a 35-item attitude scale was applied to determine the students' attitudes towards the Social studies course. The study group of the research consists of 40 7th grade students (20 experimental, 20 control). The study was carried out over a total period of 3 weeks. The experimental group was taught concepts through virtual museums in historical places, and the control group was taught according to the Social Studies curriculum. SPSS, which is a statistical analysis program, was used for the analysis of quantitative data. In the measurements related to the research, dependent and independent variable t test, mean, standard deviation values were calculated. According to the results of the analysis, it has been determined that the use of virtual museums with historical sites in social studies course concept teaching enables more effective learning compared to traditional methods and creates significant differences in students' attitudes towards social studies course.
Optimizing care for gastric cancer with overt bleeding: Is systemic therapy a valid option?
Authors: Qayed Emad
Published: October 2024

Gastric cancer (GC) and gastroesophageal junction cancer (GEJC) represent a significant burden globally, with complications such as overt bleeding (OB) further exacerbating patient outcomes. A recent study by Yao et al evaluated the effectiveness and safety of systematic treatment in GC/GEJC patients presenting with OB. Using propensity score matching, the study balanced the comparison groups to investigate overall survival and treatment-related adverse events. The study's findings emphasize that systematic therapy can be safe and effective and contribute to the ongoing debate about the management of advanced GC/GEJC with OB, highlighting the complexities of treatment decisions in these high-risk patients.
Prognostic impact of inflammatory and nutritional biomarkers in pancreatic cancer
Authors: Teja Macarena , Garrido María I , Ocanto Abrahams , Couñago Felipe
Published: October 2024

Pancreatic cancer is usually associated with a poor prognosis. Surgery is the main curative treatment but pancreatic operations are aggressive and new tools that help clinicians to predict surgical and prognostic outcomes are necessary. Lu et al recently published a retrospective, single centre cohort study evaluating the impact of seven nutritional and inflammatory markers in pancreatic cancer surgical patients: The albumin-to-globulin ratio, prognostic nutritional index (PNI), systemic immune-inflammation index (SII), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), nutritional risk index, and the geriatric nutritional risk index. A significant correlation was found between the PNI, SII, NLR, and PLR and a hospital discharge of less than 15 days. In a univariable analysis, PNI, SII, NLR and PLR were significantly related to recurrence-free survival and, in a multivariable analysis PNI was associated with overall survival. Various meta-analyses corroborate the results in terms of prognosis but individual studies are discordant on their usefulness. Besides, the cut-off values for these markers vary significantly between studies and there are no clinical trials comparing them to identify the most relevant ones. These are limitations when implementing nutritional and inflammatory biomarkers into clinical practice and further studies are needed in order to answer these questions.
Proton pump inhibitors and all-cause mortality risk among cancer patients
Authors: Krishnan Arunkumar , Schneider Carolin Victoria , Walsh Declan
Published: October 2024

BACKGROUND

Proton pump inhibitors (PPIs) are widely used, including among cancer patients, to manage gastroesophageal reflux and other gastric acid-related disorders. Recent evidence suggests associations between long-term PPI use and higher risks for various adverse health outcomes, including greater mortality.

AIM

To investigate the association between PPI use and all-cause mortality among cancer patients by a comprehensive analysis after adjustment for various confounders and a robust methodological approach to minimize bias.

METHODS

This retrospective cohort study used data from the TriNetX research network, with electronic health records from multiple healthcare organizations. The study employed a new-user, active comparator design, which compared newly treated PPI users with non-users and newly treated histamine2 receptor antagonists (H2RA) users among adult cancer patients. Newly prescribed PPIs (esomeprazole, lansoprazole, omeprazole, pantoprazole, or rabeprazole) users were compared to non-users or newly prescribed H2RAs (cimetidine, famotidine, nizatidine, or ranitidine) users. The primary outcome was all-cause mortality. Each patient in the main group was matched to a patient in the control group using 1:1 propensity score matching to reduce confounding effects. Multivariable Cox regression models were used to estimate hazard ratios (HRs) and 95% confidence interval (CI).

RESULTS

During the follow-up period (median 5.4 ± 1.8 years for PPI users and 6.5 ± 1.0 years for non-users), PPI users demonstrated a higher all-cause mortality rate than non-users after 1 year, 2 years, and at the end of follow up (HRs: 2.34-2.72). Compared with H2RA users, PPI users demonstrated a higher rate of all-cause mortality HR: 1.51 (95%CI: 1.41-1.69). Similar results were observed across sensitivity analyses by excluding deaths from the first 9 months and 1-year post-exposure, confirming the robustness of these findings. In a sensitivity analysis, we analyzed all-cause mortality outcomes between former PPI users and individuals who have never used PPIs, providing insights into the long-term effects of past PPI use. In addition, at 1-year follow-up, the analysis revealed a significant difference in mortality rates between former PPI users and non-users (HR: 1.84; 95%CI: 1.82-1.96).

CONCLUSION

PPI use among cancer patients was associated with a higher risk of all-cause mortality compared to non-users or H2RA users. These findings emphasize the need for cautious use of PPIs in cancer patients and suggest that alternative treatments should be considered when clinically feasible. However, further studies are needed to corroborate our findings, given the significant adverse outcomes in cancer patients.
Os aspectos psicossociais do suicídio na esfera pandêmica do COVID-19
Authors: Viegas Állanis Lopez Tavares , Coelho Bruno Brandão Teixeira , Melo Gabriela Câmara Nascimento de , Leite Raul Victor Caetano , Pereira Wogelsanger Oliveira
Published: October 2024

A pandemia do novo coronavírus (SARS-CoV-2) promoveu grandes alterações econômicas, políticas e, sobretudo, sociais, afetando diretamente a saúde mental da população, o que, por conseguinte, reflete nos dados epidemiológicos referentes ao fenômeno suicida, englobando tanto a ideação e o planejamento, quanto a tentativa de autoextermínio propriamente dita. Dito isso, faz-se essencial analisar a influência dessas mudanças — como a promoção do isolamento social, o desenvolvimento de uma constante sensação de insegurança e o aumento dos níveis stress - nos padrões e nas taxas do fenômeno estudado, explicitando a necessidade de adequação da postura social e governamental frente a uma realidade extrema. Portanto, esse estudo visa, por meio de uma revisão sistemática, estabelecer conexões entre as variações estatísticas observadas no período pandêmico, no que diz respeito ao quadro suicida, e as mudanças socioculturais e econômicas vivenciadas, estabelecendo correlações, também, com o surgimento de novos grupos de risco e fortalecimento de grupos já existentes.
Análise das notificações de Mpox no Brasil: um estudo ecológico
Authors: Lôbo Eduarda Araújo de Gusmão , Lado Ana Carolina Rodrigues , Rezende Thaís Coutinho de , Silva Silvia Jordania Barboza da , Ruela Guilherme de Andrade
Published: October 2024

OBJETIVO: Analisar as notificações de Mpox no Brasil. MÉTODOS: Estudo ecológico. Foram retirados dados do boletim especial do Ministério da Saúde, elaborado pela Secretaria de Vigilância em Saúde e Ambiente, acerca das notificações de Monkeypox entre os meses de maio de 2022 e 2023. Foram analisadas de forma estatística e descritiva a distribuição espacial das variáveis: sexo; gênero; raça e idade. RESULTADOS: Foram registradas 53.091 notificações, 19,7% confirmadas. Maior incidência no sexo masculino, os quais 70,5% declararam-se como homens cis e 53,7% afirmaram realizar sexo com homens. No quesito raça/cor negra e branca, a pesquisa revelou uma proporção semelhante, com 42,2 e 41,1%. CONCLUSÃO: A análise permitiu uma melhor visualização acerca dos acometidos pelo Mpox, ratificando a importância que o fortalecimento de ações de vigilância em saúde tem mediante situações de assistência médica e informatização da população no geral.
Becheck DMG: um aplicativo móvel para manejo da diabetes durante a gestação
Authors: Araújo Lívia Maria Azevedo de , Lima Joaquim Gomes de , Cobucci Ricardo Ney , Pinto Ciro Martins , Vale Adson José Martins
Published: October 2024

OBJETIVO: Apresentar o desenvolvimento do aplicativo BeCheck DMG, ferramenta com o potencial de contribuir para o acompanhamento, manejo e redução de desfechos desfavoráveis nas pacientes portadoras de diabetes mellitus no período gestacional. MÉTODOS: Trata-se de um trabalho descritivo sobre o desenvolvimento de um aplicativo destinado à prática clínica construído com base na metodologia Design Science Research (DSR). Para isso, foram realizadas pesquisas bibliográficas sobre a utilização de novas tecnologias no acompanhamento gestacional, mais especificamente na terapêutica em casos de Diabetes Mellitus Gestacional (DMG). Desse modo, após a percepção do problema, foram elaboradas algumas telas que iriam compor a aplicação como, por exemplo, as seções de identificação, pré-natal, resumo clínico, entre outros. Foram utilizadas algumas ferramentas, dentre as quais podem-se citar o aplicativo Freeform e Figma. Já para a elaboração do back-end, utilizou-se da tecnologia Spring Security com uma autenticação baseada em JSON Web Token (JWT). RESULTADOS: O desenvolvimento resultou em um aplicativo móvel com manuseio fácil e didático, para ser utilizado livremente por médico e paciente, com acesso a todas as telas do aplicativo, porém com possibilidades de edição diferentes, utilizando-se de telas de login, cadastro, primeira consulta, exames complementares, inserir medidas de HGT e resumo clínico. CONCLUSÃO: O aplicativo tem potencial para melhorar a gestão da DMG, promovendo melhores práticas clínicas durante o pré-natal, parto e puerpério. A utilização desta tecnologia visa aprimorar a coordenação do trabalho da equipe de atendimento, ao oferecer uma solução acessível e segura para profissionais de saúde e pacientes no contexto da saúde obstétrica.
EVALI associado à hemorragia alveolar grave e pneumonia em organização
Authors: Quidigno Camila Alcantara , Ferreira Pedro de Freitas , Guerra Daniela de Lima , Feitosa Paulo Henrique Ramos
Published: October 2024

Este caso reporta um paciente do sexo masculino, 32 anos, usuário de cigarro eletrônico, com relato de hemoptise, dispneia aos grandes esforços, sudorese noturna e cansaço, com piora progressiva. Fez uso a nível ambulatorial de antibioticoterapia oral, evoluindo sem melhora clínica, com piora importante do padrão respiratório e da hemoptise (aproximadamente 600 mililitros). Tomografia (TC) de tórax evidenciando consolidações irregulares em ambos os pulmões, predominando nos campos superiores e médios. Em internação hospitalar, iniciado antibioticoterapia venosa, corticoide, oxigênio no cateter nasal e cessado uso de cigarro eletrônico. Nova TC de tórax com melhora de áreas consolidativas após tratamento, levantando o diagnóstico de EVALI associado a hemorragia alveolar grave e provável pneumonia em organização. Como o fator de risco é o uso de cigarro eletrônico ou produto similar, este caso demonstra a importância de maior orientação e conscientização dos jovens e adultos a respeito da cessação do uso deste dispositivo.
Escetamina no tratamento da depressão resistente: revisão de literatura
Authors: Vale Camila da Fonte Porto Carreiro de Lima , Oliveira Leticia Souza de , Costa Heloísa Macedo de Araújo Matias da , Melo Isabella Amaral Duarte , Veras João Victor Mendonça , Medeiros Maria Cecilia Fernandes de , Padilha Deborah de Melo Magalhães
Published: October 2024

OBJETIVO: Revisar a literatura sobre a eficácia da ação antidepressiva e anti-suicida da escetamina na depressão resistente ao tratamento (DRT). MÉTODOS: Revisão integrativa de literatura realizada entre agosto e dezembro de 2023 nas bases de dados PubMed/Medline, SciELO e Lilacs. A pesquisa selecionou 54 estudos após aplicar critérios de inclusão, como publicação nos últimos cinco anos, acesso livre à íntegra, título e resumo. RESULTADOS: A escetamina possui ação antidepressiva e anti-suicida otimizada devido ao agonismo dos receptores AMPA e elevação do BNF, promovendo neuroplasticidade e uma resposta terapêutica rápida. A administração intranasal requer supervisão profissional para gerenciar efeitos adversos agudos. Apesar de apresentar desempenho clínico inferior à cetamina racêmica intravenosa, a escetamina ainda exibe benefícios essenciais no tratamento da DRT. CONCLUSÃO: A administração intranasal da escetamina, especialmente em combinação com antidepressivos convencionais, resulta em melhorias rápidas e substanciais nos sintomas depressivos. A eficácia na prevenção de recaídas e na redução da ideação suicida destaca a importância clínica como uma alternativa promissora para pacientes que não respondem aos tratamentos convencionais, configurando a escetamina uma candidata ideal ao tratamento da DRT.