bluuebunny/crossref_metadata_2025 huggingface dataset:
Features of protocols of assisted reproductive technologies in patients of the older age group depending on the ovarian stimulation drug: recombinant follicle-stimulating hormone or highly purified human menopausal gonadotropins
Authors: Kraevaya E. E.
Published: October 2022

Introduction. An actual task of reproductive medicine is a comparative analysis of the use of highly purified urinary gonadotropins and recombinant FSH preparations for ovarian stimulation in in vitro fertilization programms in older patients. This was suggested on the basis of data available in the literature on the possible positive effect of LH on the effectiveness of various stages of ART programs in this category of women.   Aim. To compare the parameters of ovarian stimulation, gametogenesis, early embryogenesis, pregnancy rate (PRF) in patients of older reproductive age in ART programs who underwent ovarian stimulation using drugs containing FSH + LH or drugs containing recombinant FSH.   Materials and methods. The study included 44 patients aged 35 to 40 years with infertility due to tubal- peritoneal and non-severe male factor treated with ART techniques. In 50% of patients, ovarian stimulation was performed with highly purified urinary gonadotropin, in 50 % – with rFSH preparations.   Results. The characteristics of the embryological stage in both groups showed high rates, comparable with global data. The frequency of pregnancy and early miscarriage was comparable in both groups.   Conclusions. Ovarian stimulation with MHT is effective, safe and can be recommended for patients of older reproductive age.
Penggalian Potensi Usaha BUMK Hendro Mulyo, Lampung Tengah
Authors:   Politeknik Keuangan Negara STAN, Sektor V, Jl. Bintaro Utama 5, Jurang Manggu Tim., Kec. Pd. Aren, Kota Tangerang Selatan, Banten 15222, Kurnianingsih Puji , Fadila Syuja Andika ,   Politeknik Keuangan Negara STAN, Sektor V, Jl. Bintaro Utama 5, Jurang Manggu Tim., Kec. Pd. Aren, Kota Tangerang Selatan, Banten 15222, Adi Fahrizal ,   Politeknik Keuangan Negara STAN, Sektor V, Jl. Bintaro Utama 5, Jurang Manggu Tim., Kec. Pd. Aren, Kota Tangerang Selatan, Banten 15222, Prihandini Nabilla Ulfah ,   Politeknik Keuangan Negara STAN, Sektor V, Jl. Bintaro Utama 5, Jurang Manggu Tim., Kec. Pd. Aren, Kota Tangerang Selatan, Banten 15222, Kurniawan Reza ,   Politeknik Keuangan Negara STAN, Sektor V, Jl. Bintaro Utama 5, Jurang Manggu Tim., Kec. Pd. Aren, Kota Tangerang Selatan, Banten 15222, Permita Sari Saraswati ,   Politeknik Keuangan Negara STAN, Sektor V, Jl. Bintaro Utama 5, Jurang Manggu Tim., Kec. Pd. Aren, Kota Tangerang Selatan, Banten 15222, Raharjo Taufik ,   Politeknik Keuangan Negara STAN, Sektor V, Jl. Bintaro Utama 5, Jurang Manggu Tim., Kec. Pd. Aren, Kota Tangerang Selatan, Banten 15222, Sulaeman Agus Sunarya ,   Politeknik Keuangan Negara STAN, Sektor V, Jl. Bintaro Utama 5, Jurang Manggu Tim., Kec. Pd. Aren, Kota Tangerang Selatan, Banten 15222
Published: October 2022

The Village Owned Enterprises (BUMK) Hendro Mulyo was established by the Government of Tempuran Village, Trimurjo District, Central Lampung Regency. Although it is strategically located, BUMK has not been able to explore business potential following the conditions of the local community. The purpose of this community service activity is to explore the potential of the village as a form of BUMK business and make a Budget Plan for BUMK businesses. The result of community service activities is that BUMK management has established a business form and can plan their business budget.
Pendampingan Pemasaran Produk UMKM Slow Food Menggunakan Sosial Media Facebook
Authors:   Universitas Serang Raya, Jl. Raya Cilegon No.Km. 5, Taman, Drangong, Kec. Taktakan, Kota Serang, Banten 42162, Indonesia, Karyaningsih Dentik , Safaah Eva ,   Universitas Serang Raya, Jl. Raya Cilegon No.Km. 5, Taman, Drangong, Kec. Taktakan, Kota Serang, Banten 42162, Indonesia, Fachriah Eva ,   Universitas Serang Raya, Jl. Raya Cilegon No.Km. 5, Taman, Drangong, Kec. Taktakan, Kota Serang, Banten 42162, Indonesia, Felycia Felycia ,   Universitas Serang Raya, Jl. Raya Cilegon No.Km. 5, Taman, Drangong, Kec. Taktakan, Kota Serang, Banten 42162, Indonesia
Published: October 2022

The livelihoods of most residents in Lebak district are rainfed rice farming, gardening, in addition to raising goats. Many of the plantation commodities that generate income for the villagers in Lebak Regency include plantation products such as rubber, oil palm, cocoa, robusta coffee, sugar palm, cloves, coconut, hybrid coconut, pepper, pandan, tea, cashew nuts, vanilla, jatropha, jatropha, and Kapok. In addition, the difficulty of transportation in some areas of Lebak Regency makes it difficult for farmers to market their products. Electricity in Lebak is supplied by PLN continuously, but there are still some areas that have not been touched by electricity at all, so the residents still rely on oil lamps as a means of lighting at night. Phone and GPRS signal is still difficult. This condition is what causes the marketing of products produced by farmers or MSME actors is still marketed in their respective regions and even the barter process is still going on (exchanging goods). During the Covid-19 Pandemic, Slow Food MSME actors experienced a decline in sales due to a decline in people's purchasing power which was the effect of the covid-19 pandemic. From some of these problems, community service will provide training and socialization of the use of information technology, namely by providing knowledge on the use of Facebook social media as a means of marketing MSME products, with the aim that Slow Food MSME business actors can continue to market their products and increase people's purchasing power towards Slow Food MSME products. It is hoped that after participating in the training and socialization, Slow Food MSME business actors have an online buying and selling account through Facebook that is easy, effective, and safe so that they can increase product marketing not only in their own region, but also on a national and international scale.
Pengembangan Strategi Pemasaran UMKM Dapur Tihwa Pada Masa Pandemi Covid-19
Authors:   Universitas Prasetiya Mulya, Edutown BSD Campus Kavling Edu I.1, Jl. BSD Raya Utama, BSD City, Serpong - Tangerang , Indonesia 15820, Hartini Halim Imelda , Sukmana Ariq Naufal Aqilla ,   Universitas Prasetiya Mulya, Edutown BSD Campus Kavling Edu I.1, Jl. BSD Raya Utama, BSD City, Serpong - Tangerang , Indonesia 15820, Victoria Benedicta ,   Universitas Prasetiya Mulya, Edutown BSD Campus Kavling Edu I.1, Jl. BSD Raya Utama, BSD City, Serpong - Tangerang , Indonesia 15820, Vinsky Elvin ,   Universitas Prasetiya Mulya, Edutown BSD Campus Kavling Edu I.1, Jl. BSD Raya Utama, BSD City, Serpong - Tangerang , Indonesia 15820, Christopher Jessica ,   Universitas Prasetiya Mulya, Edutown BSD Campus Kavling Edu I.1, Jl. BSD Raya Utama, BSD City, Serpong - Tangerang , Indonesia 15820, Wijaya Meryssa ,   Universitas Prasetiya Mulya, Edutown BSD Campus Kavling Edu I.1, Jl. BSD Raya Utama, BSD City, Serpong - Tangerang , Indonesia 15820, Jonathan Rorong Raynard ,   Universitas Prasetiya Mulya, Edutown BSD Campus Kavling Edu I.1, Jl. BSD Raya Utama, BSD City, Serpong - Tangerang , Indonesia 15820, Ginting Maydison ,   Universitas Prasetiya Mulya, Edutown BSD Campus Kavling Edu I.1, Jl. BSD Raya Utama, BSD City, Serpong - Tangerang , Indonesia 15820
Published: October 2022

During the Covid-19 pandemic, lots of businesses were negatively affected, one of which is Dapur Tihwa, a Small Medium Enterprises (SME) around Cianjur which sells various types of food such as cireng and seblak. Not only external challenges such as the pandemic period which resulted in Dapur Tihwa decreased sales up to 50%, there's many internal problems experienced by Dapur Tihwa such as production, finance, marketing, distribution, and mindset. In fact, as we all know, Small Medium Enterprises (SME) have a major contribution due to Indonesia's macro economy. Therefore, during the community development opportunity held by Universitas Prasetiya Mulya and based on the analysis that has been carried out by the group, the group will focusing on conducting research especially in the marketing department by improving Dapur Tihwa marketing strategy with the intention to increase affected sales during this Covid-19 pandemic. Through intensive assistance, our partner has succeeded in obtaining new, more attractive packaging stickers, knowledge in digital technology, as well as the addition of marketing and sales media, namely Shopee and Tokopedia.
Pengembangan UMKM Cho Cweet melalui Program Community Development
Authors:   Universitas Prasetiya Mulya, Edutown BSD Campus Kavling Edu I.1, Jl. BSD Raya Utama, BSD City, Serpong - Tangerang , Indonesia 15820, Hosea Jason Evander , Filbert Keandre ,   Universitas Prasetiya Mulya, Edutown BSD Campus Kavling Edu I.1, Jl. BSD Raya Utama, BSD City, Serpong - Tangerang , Indonesia 15820, Jasmine Livia ,   Universitas Prasetiya Mulya, Edutown BSD Campus Kavling Edu I.1, Jl. BSD Raya Utama, BSD City, Serpong - Tangerang , Indonesia 15820, Darmawan Putu ,   Universitas Prasetiya Mulya, Edutown BSD Campus Kavling Edu I.1, Jl. BSD Raya Utama, BSD City, Serpong - Tangerang , Indonesia 15820, Susanto Yohana Stella ,   Universitas Prasetiya Mulya, Edutown BSD Campus Kavling Edu I.1, Jl. BSD Raya Utama, BSD City, Serpong - Tangerang , Indonesia 15820, Zulandari Peni ,   Universitas Prasetiya Mulya, Edutown BSD Campus Kavling Edu I.1, Jl. BSD Raya Utama, BSD City, Serpong - Tangerang , Indonesia 15820
Published: October 2022

Community Development is an entrepreneurship-based Community Service program with the aim of increasing partners’ understanding of basic business management, motivation in running a business, and increasing welfare in the form of income growth through business development. Community Development 2021 will be carried out online. The group had the opportunity to provide assistance with a Micro, Small and Medium Enterprises, “Cho Cweet” as a partner. In providing assistance, the group assists in the development of one of the partner's products, optimizes online sales, and conducts partner financial analysis. The results we get are quite good and our partner felt very helpful with the guidance of this Community Development program. Our partner’s income also increased during the mentoring program
Identifying Barriers and Enablers to Vaccine uptake from Immunizers and Individuals Receiving a COVID-19 Vaccine in Saskatchewan
Authors: Vanstone Jason Robert , Azizian Amir Reza , Berry Warren , Carr Tracey , Falastein Patrick , Mise Taysa-Rhea , Patel Shivani , Sarker Kinsuk Kalyan , Yasinian Maryam , Groot Gary
Published: October 2022

Background:

Vaccine hesitancy presents a challenge to public health, especially during a global pandemic. Understanding reasons for vaccine hesitancy in local populations may help policymakers and public health practitioners increase vaccine uptake.

Objective:

We surveyed individuals receiving a COVID-19 vaccine and immunizers in Saskatchewan, Canada and categorized their responses according to the Theoretical Domains Framework. This provides policymakers with evidence-based suggestions for behaviour change interventions that may promote vaccine uptake among hesitant individuals.

Methods:

Two online surveys were developed to better understand vaccine hesitancy in Saskatchewan: one aimed at individuals receiving a vaccination and the other at immunizers. Both surveys were available for a one-week period when vaccination uptake had plateaued in Saskatchewan. Individuals receiving a vaccine were asked what made them decide to get a vaccine, and both groups were asked what they thought would promote vaccine uptake among hesitant individuals. Responses were analyzed thematically based on the Theoretical Domains Framework and reported descriptively.

Results:

Individuals receiving a COVID-19 vaccine indicated that mandates and restrictions and having a positive attitude toward COVID-19 vaccines were the most common reasons for receiving a vaccine. Immunizers most frequently indicated that media issues led to vaccine hesitancy and that having access to, and trust in, reputable information sources would enable more vaccine hesitant individuals to seek a COVID-19 vaccination.

Conclusion:

Mandates and restrictions, promoting positive attitudes towards vaccines, and ensuring people have access to, and trust in, reputable information sources, are key enablers for promoting vaccine uptake among vaccine hesitant individuals.
Associations of whole body reaction time with anaerobic power performance among Saudi athletes in different sports
Authors:   Department of Physiology, Faculty of Medicine, King Saud University, Riyadh, Saudi Arabia, Alhowikan Abdulrahman M. , Altaweraqi Reema A. ,   Department of Physiology, Faculty of Medicine, King Saud University, Riyadh, Saudi Arabia, Halepoto Dost M. ,   Department of Physiology, Faculty of Medicine, King Saud University, Riyadh, Saudi Arabia, Al-Hazzaa Hazzaa M. ,   Lifestyle and Health Sciences Research Centre, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia
Published: October 2022

This study aims to analyze the associations between whole-body reaction-movement time (RT) and anaerobic power performance among Saudi athletes participating in different sports. Fifty athletes (age 18-26 years) of four different sport groups representing sprinters (SP, n=12), fencers (FN, n=13), table tennis player (TT, n=12) long-distance runner (LD, n=13), and one non-athlete group (NA, n=8) participated in the study. All groups performed Wingate Anaerobic Test (WAnT), and the vertical jump (VJ) test. RT was recorded using a sound (RT-S), light (RT-L), and a choice of light (RT-C). There were no significant differences in reaction-movement time between LD, SP, FN, TT, or NA groups. However, tests between subjects showed significant differences relative to sport type in muscular power (p=0.011), absolute maximal anaerobic power (p=0.008), absolute average anaerobic power in 30 seconds (p=0.001), average anaerobic power relative to body weight (p=0.007), and in fatigue index (p=0.028). Fencers recorded the highest values in absolute anaerobic power, absolute average power in 30 seconds, and average anaerobic power relative to body mass. Sprinters showed the highest decrement in anaerobic power during the 30-second test (18.7±6.0 watts/sec). Partial correlation coefficients (r) of selected anthropometric variables with reaction time and anaerobic power were calculated. This study showed that there were no significant changes in reaction-movement time between LD, SP, FN, TT, or NA groups. However, tests between subjects showed significant differences relative to sport type in muscular power, absolute maximal anaerobic power, absolute average anaerobic power in 30 seconds, average anaerobic power relative to body weight, and fatigue index.
Impact of the Mobile Game FightHPV on Cervical Cancer Screening Attendance: Retrospective Cohort Study
Authors: Orumaa Madleen , Campbell Suzanne , Støer Nathalie C , Castle Philip E , Sen Sagar , Tropé Ameli , Adedimeji Adebola , Nygård Mari
Published: October 2022

Background

The wide availability of mobile phones has made it easy to disseminate health-related information and make it accessible. With gamification, mobile apps can nudge people to make informed health choices, including attending cervical cancer screening.

Objective

This matched retrospective cohort study examined the association between exposure to the FightHPV mobile app gamified educational content and having a cervical exam in the following year.

Methods

Women aged 20 to 69 years who signed an electronic consent form after downloading the FightHPV app in 2017 (intervention group) were matched 1:6 with women of the same age and with the same screening history (reference group) in 2015. To estimate the impact of exposure to the FightHPV app, we estimated cumulative incidence and hazard ratios (HRs) with 95% CIs. We used data from the Norwegian Cervical Cancer Screening Program database and Statistics Norway to determine screening participation and outcomes, respectively.

Results

We matched 3860 women in the control group to 658 women in the intervention group; 6 months after enrollment, 29.6% (195/658) of the women in the intervention group and 15.21% (587/3860) of those in the reference group underwent a cervical exam (P<.01). Women exposed to the FightHPV app were 2 times more likely to attend screening (adjusted HR 2.3, 95% CI 2.0-2.7), during which they were 13 times more likely to be diagnosed with high-grade abnormality (adjusted HR 12.7, 95% CI 5.0-32.5) than the women in the reference group.

Conclusions

Exposure to the FightHPV app significantly increased cervical cancer screening attendance across the various analyses and improved detection of women with high risk for cervical cancer. For the first time, we demonstrated the effectiveness of gamification combined with mobile technology in cancer prevention by empowering women to make active health-related decisions. Gamification can significantly improve the understanding of complicated scientific concepts behind interventions and increase the acceptance of proposed cancer control measures.
Methodological Frameworks and Dimensions to Be Taken Into Consideration in Digital Health Technology Assessment: Protocol for a Scoping Review
Authors: Segur-Ferrer Joan , Moltó-Puigmartí Carolina , Pastells-Peiró Roland , Vivanco-Hidalgo Rosa Maria
Published: October 2022

Background

Health technology assessment (HTA) is one of the main tools that health systems have to appraise evidence and determine the value of a given health technology. Although the existing HTA frameworks are useful tools for the evaluation of a wide range of health technologies, more and more experts, organizations across the world, and HTA agencies are highlighting the need to update or develop specific methodological frameworks for the evaluation of digital health technologies in order to take into account additional domains that cover these technologies’ intrinsic characteristics.

Objective

The purpose of our scoping review is to identify the methodological frameworks that are used worldwide for the assessment of digital health technologies; determine what dimensions and aspects are being considered; and generate, through a thematic analysis, a proposal for a methodological framework that is based on the most frequently described dimensions in the literature.

Methods

The scoping review will be performed in accordance with the guidelines established in the updated statement of the PRISMA-ScR (Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews). We will search for peer-reviewed and grey literature published between 2011 and the date of the search execution. The retrieved references will be reviewed in a single-blind manner by 2 independent authors, and their quality will be assessed by using the Critical Appraisal Skills Program tool. The ATLAS.ti software (Scientific Software Development GmbH) will be used for data extraction and to perform the thematic analysis.

Results

The scoping review is currently (May 2022) in progress. It is expected to be completed in October 2022, and the final results of the research will be presented and published by November 2022.

Conclusions

To our knowledge, no studies have been published to date that identify the existing methodological frameworks for digital HTA, determine which dimensions must be evaluated for correct decision-making, and serve as a basis for the development of a methodological framework of reference that health care systems can use to carry out this kind of assessment. This work is intended to address this knowledge gap of key relevance for the field of HTA.

International Registered Report Identifier (IRRID)

DERR1-10.2196/39905
This is test 2 11 Oct 2022 (Preprint)
Authors: Account DeveloperX
Published: October 2022

UNSTRUCTURED

This is test 2 11 Oct 2022
No-show Prediction Model Performance Among People With HIV: External Validation Study (Preprint)
Authors: Mason Joseph A , Friedman Eleanor E , Rojas Juan C , Ridgway Jessica P
Published: October 2022

BACKGROUND

Regular medical care is important for people living with HIV. A no-show predictive model among people with HIV could improve clinical care by allowing providers to proactively engage patients at high risk of missing appointments. Epic, a major provider of electronic medical record systems, created a model that predicts a patient’s probability of being a no-show for an outpatient health care appointment; however, this model has not been externally validated in people with HIV.

OBJECTIVE

We examined the performance of Epic’s no-show model among people with HIV at an academic medical center and assessed whether the performance was impacted by the addition of demographic and HIV clinical information.

METHODS

We obtained encounter data from all in-person appointments among people with HIV from January 21 to March 30, 2022, at the University of Chicago Medicine. We compared the predicted no-show probability at the time of the encounter to the actual outcome of these appointments. We also examined the performance of the Epic model among people with HIV for only HIV care appointments in the infectious diseases department. We further compared the no-show model among people with HIV for HIV care appointments to an alternate random forest model we created using a subset of seven readily accessible features used in the Epic model and four additional features related to HIV clinical care or demographics.

RESULTS

We identified 674 people with HIV who contributed 1406 total scheduled in-person appointments during the study period. Of those, we identified 331 people with HIV who contributed 440 HIV care appointments. The performance of the Epic model among people with HIV for all appointments in any outpatient clinic had an area under the receiver operating characteristic curve (AUC) of 0.65 (95% CI 0.63-0.66) and for only HIV care appointments had an AUC of 0.63 (95% CI 0.59-0.67). The alternate model we created for people with HIV attending HIV care appointments had an AUC of 0.78 (95% CI 0.75-0.82), a significant improvement over the Epic model restricted to HIV care appointments (P<.001). Features identified as important in the alternate model included lead time, appointment length, HIV viral load >200 copies per mL, lower CD4 T cell counts (both 50 to <200 cells/mm3 and 200 to <350 cells/mm3), and female sex.

CONCLUSIONS

For both models among people with HIV, performance was significantly lower than reported by Epic. The improvement in the performance of the alternate model over the proprietary Epic model demonstrates that, among people with HIV, the inclusion of demographic information may enhance the prediction of appointment attendance. The alternate model further reveals that the prediction of appointment attendance in people with HIV can be improved by using HIV clinical information such as CD4 count and HIV viral load test results as features in the model.
A Digital Health Fall Prevention Program for Older Adults: Feasibility Study (Preprint)
Authors: Arul Hari
Published: October 2022

BACKGROUND

About 1 in 3 adults aged 65 and older falls annually. Exercise interventions are effective in reducing the fall risk and fall rate among older adults. In 2020, startup company Age Bold Inc. disseminated the Bold Fall Prevention Program, aiming to reduce falls among older adults through a remotely delivered, digital exercise program.

OBJECTIVE

We conducted a feasibility study to assess the delivery of the Bold Fall Prevention Program remotely and evaluate the program's impact on 2 primary outcomes—annualized fall rate and weekly minutes of physical activity (PA)—over 6 months of follow-up.

METHODS

Older adults at high risk of falling were screened and recruited for the feasibility study via nationwide digital advertising strategies. Self-reported outcomes were collected via surveys administered at the time of enrollment and after 3 and 6 months. Responses were used to calculate changes in the annualized fall rate and minutes of PA per week.

RESULTS

The remote delivery of a progressive digital fall prevention program and associated research study, including remote recruitment, enrollment, and data collection, was deemed feasible. Participants successfully engaged at home with on-demand video exercise classes, self-assessments, and online surveys. We enrolled 65 participants, of whom 48 (74%) were women, and the average participant age was 72.6 years. Of the 65 participants, 54 (83%) took at least 1 exercise class, 40 (62%) responded to at least 1 follow-up survey at either 3 or 6 months, 20 (31%) responded to both follow-up surveys, and 25 (39%) were lost to follow-up. Among all participants who completed at least 1 follow-up survey, weekly minutes of PA increased by 182% (ratio change=2.82, 95% CI 1.26-6.37, n=35) from baseline and annualized falls per year decreased by 46% (incidence rate ratio [IRR]=0.54, 95% CI 0.32-0.90, n=40). Among only 6-month survey responders (n=31, 48%), weekly minutes of PA increased by 206% (ratio change=3.06, 95% CI 1.43-6.55) from baseline to 6 months (n=30, 46%) and the annualized fall rate decreased by 28% (IRR=0.72, 95% CI 0.42-1.23) from baseline to 6 months.

CONCLUSIONS

The Bold Fall Prevention Program provides a feasible strategy to increase PA and reduce the burden of falls among older adults.
Role of glycated hemoglobin in microvascular complications in type 2 diabetes mellitus: cross sectional study
Authors: Puri Deepika , Kaur Jaspreet , Gaur Naveen , Kodidala Satyanath Reddy
Published: October 2022

Background. Diabetes mellitus (DM) is a complex disorder which defects mainly vascular complications. Complications increase the morbidity and mortality associated with the disease, reducing life expectancy by 10–15 years. Diabetic neuropathy (DN) is a frequent complication of DM and is defined as the presence of peripheral nerve dysfunction after exclusion of other causes. Poor glycaemic control and chronic hyperglycaemia are the major risk factors for DN. Most important treatment of DN remains good glucose control generally noted as HbA1c ≤ 7.5 %. The purpose of this cross-sectional study is to investigate the role of glycated hemoglobin in microvascular complications in type 2 diabetes mellitus. Materials and methods. This cross-sectional study was carried out in Teerthanker Mahaveer Medical College and Research Center, Moradabad from Jan 2016 to December 2016 in which 100 type 2 diabetic mellitus (T2DM) patients in the age group of 35–69 years were included. Patients were divided into 2 groups of 50 each. Group 1 constituted of T2DM patients without any microvascular complication and group 2 includes T2DM patients with microvascular complications. Examination of patients included recording of medical history, pulse rate and blood pressure. Neuropathy was assessed by clinical examination based on modified NDS procedure, which included examination of vibration, pin prick sensation, temperature sensation on dorsum of foot and Achilles tendon reflex. Blood samples were collected by venepuncture and accordingly biochemistry analysis was carried out (Fasting Blood Glucose, post prandial blood glucose and HbA1c were recorded). HbA1c estimation was done by using COBAS fully automated analyser. Results. Among recruited patients, Mean fasting, PPBS level, HbA1c among test group was significantly more than control group. In control group significant correlation of HbA1c is found with age, weight and BMI and in test group significant correlation of HbA1c is observed with age and duration of DM. Significant correlation of HbA1c with FBS and PPBS seen in both control group and in test group. Among test group, 19 patients were found to have DN and significant correlation of HbA1c is observed with NDS score. Conclusions. Increased HbA1c is closely associated with DN in T2DM patients and could be considered as a potent indicator for DN in these patients.
Kidney-Protective Effects of SGLT2 Inhibitors
Authors: Palmer Biff F. , Clegg Deborah J.
Published: October 2022

The sodium-glucose cotransporter 2 (SGLT2) inhibitors have become an integral part of clinical practice guidelines to slow the progression of CKD in patients with and without diabetes mellitus. Although initially developed as antihyperglycemic drugs, their effect on the kidney is multifactorial resulting from profuse glycosuria and natriuresis consequent to their primary site of action. Hemodynamic and metabolic changes ensue that mediate kidney-protective effects, including (1) decreased workload of proximal tubular cells and prevention of aberrant increases in glycolysis, contributing to a decreased risk of AKI; (2) lowering of intraglomerular pressure by activating tubular glomerular feedback and reductions in BP and tissue sodium content; (3) initiation of nutrient-sensing pathways reminiscent of starvation activating ketogenesis, increased autophagy, and restoration of carbon flow through the mitochondria without production of reactive oxygen species; (4) body weight loss without a reduction in basal metabolic rate due to increases in nonshivering thermogenesis; and (5) favorable changes in quantity and characteristics of perirenal fat leading to decreased release of adipokines, which adversely affect the glomerular capillary and signal increased sympathetic outflow. Additionally, these drugs stimulate phosphate and magnesium reabsorption and increase uric acid excretion. Familiarity with kidney-specific mechanisms of action, potential changes in kidney function, and/or alterations in electrolytes and volume status, which are induced by these widely prescribed drugs, will facilitate usage in the patients for whom they are indicated.
Current Issues within the U.S. History Curricula
Authors: Intravaia Brittany D.
Published: October 2022

North Carolina recently implemented new social studies standards for each content area. However, there has been some controversy over whether the standards truly represent U.S. History and racial equity. However, opponents argue that this makes the U.S. History too political and includes topics that are too sensitive for students. As the population of the United States increases in diversity, it is essential that students are exposed to diverse perspective within their history lessons.
Evaluierung des Programms Klima- und Energie-Modellregionen
Authors:   Wuppertal Institut, Schüle Ralf , Schepelmann Philipp , Fischl Iris , Kaufmann Joachim ,   KMU Forschung Austria
Published: October 2022

Klima- und Energie-Modellregionen (KEM) ist ein Programm des österreichischen Klima- und Energiefonds, das Gemeinden und Regionen bei der Umsetzung von Klimaschutzmaßnahmen unterstützt. KEM folgt dabei der Leitvorgabe des Fonds, die Senkung der Treibhausgasemissionen Österreichs so schnell und nachhaltig wie möglich umzusetzen und dabei regionale Wertschöpfung und Arbeitsplätze zu generieren. Eine Evaluierung des Programms wurde durch das Wuppertal Institut und der KMU Forschung Austria zwischen Oktober 2018 und Juni 2019 durchgeführt. Ein breites Spektrum von Erhebungsmethoden kam darin zur Anwendung, durch die das Konzept und die Ziele des Programms, die Qualität des Programmmanagements und dessen Wirkungen evaluiert wurden. Insbesondere über zahlreiche Interviews mit Experten und Expertinnen, eine Online-Befragung der KEM-Managerinnen und -Manager und quantitative Wirkungsberechnungen getätigter Investförderungen konnten eine Fülle von Informationen gewonnen werden, anhand derer Vorschläge zur Weiterentwicklung und Verbesserung des Programms formuliert wurden.
Evaluation des nationalen Programms für Weltraum und Innovation
Authors:   iit – Institut für Innovation und Technik VDI/VDE-IT, Bießlich Susan , von Engelhardt Sebastian , Kaufmann Peter , Kerlen Christiane , Kind Sonja , Kofler Jakob , Marcher Anja , Nindl Elisabeth , Robeck Martin , Rodriguez Karoline , Zinke Guido
Published: October 2022

Mit dem Nationalen Programm für Weltraum und Innovation - Forschungs- und Entwicklungsvorhaben (NPWI) stärkt das deutsche Bundesministerium für Wirtschaft und Energie (BMWi) die Innovations- und Wettbewerbsfähigkeit des deutschen Raumfahrtinnovationsökosystems aus Forschung und Industrie. Orientierungsrahmen des NPWI ist die Raumfahrtstrategie der Bundesregierung „Für eine zukunftsfähige deutsche Raumfahrt“. Umgesetzt wird das Programm durch das DLR Raumfahrtmanagement (DLR-RFM). Für die hier vorliegende Evaluation des NPWI für 2011 bis 2018 beauftragte das BMWi das Institut für Innovation und Technik und seine Partner Kerlen Evaluation und KMU Forschung Austria. Analysiert und bewertet wurde, inwieweit das NPWI seine Ziele erreichte, welche Wirkungen es zeitigte und wie es wirtschaftlich umgesetzt wurde. Angesichts identifizierter Anpassungsbedarfe wurden Handlungsempfehlungen an das BMWi sowie das DLR-Raumfahrtmanagement gerichtet.
Wirkungsmonitoring der FFG Förderungen 2021 Unternehmen und Forschungseinrichtungen
Authors:   KMU Forschung Austria, Kofler Jakob , Kaufmann Joachim , Kaufmann Peter
Published: October 2022

Das Wirkungsmonitoring 2021 bezieht sich auf im Jahr 2017 beendete Forschungsprojekte ab einer gewissen Mindestgröße, für die kein programmspezifisches Monitoring der FFG durchgeführt wird.1 In diesem Jahr wurden zudem die Einflussfaktoren auf die wirtschaftliche Verwertung von Projektergebnissen gesondert in der Befragung berücksichtigt. Es konnten 92 % der Unternehmen erreicht werden; der Netto-Rücklauf beträgt 61 % (372 Projektteilnahmen). In diesem Berichtsjahr ist erstmals der Anteil an Projektbeteiligungen an Thematischen Programmen im Wirkungsmonitoring größer als jener der Basisprogramme. Die Projektbeteiligungen verteilen sich auf 54 % Thematische Programme, 42 % Basisprogramme, 2 % Strukturprogramme sowie 2 % Luft- und Raumfahrtprojekte. Forschungseinrichtungen (FE) werden im Wirkungsmonitoring ebenfalls berücksichtigt, weisen im Vergleich zu Unternehmen jedoch typischerweise weniger Projektteilnahmen auf. Insgesamt wurden 502 Projektteilnahmen erreicht und 344 Fragebögen ausgewertet. Dies entspricht einem Netto-Rücklauf von rd. 69 %.
Welche Hebel hat die angewandte Forschungsförderung zur Unterstützung von Frauen in der Forschung?
Authors:   KMU Forschung Austria, Heckl Eva , Kofler Jakob
Published: October 2022

Die FFG hat diese Kurzstudie beauftragt, um zum einen den Status quo in Hinblick auf die Repräsentanz von Frauen in den von ihr geförderten Projekten zu untersuchen, und zum anderen zu analysieren, welche Maßnahmen eine Agentur wie die FFG setzen kann bzw. welche bereits implementierten Maßnahmen am vielversprechendsten erscheinen. Methodisch stützt sich die Kurzstudie auf eine Sonderauswertung im Rahmen des Wirkungsmonitorings der von der FFG geförderten Projekte sowie einer Literaturanalyse, die insbesondere Metastudien und graue Literatur (insbesondere auf EU-Ebene) sowie Evaluierungen inkludiert. Die FFG setzt eine Reihe von Maßnahmen zur Förderung der Gleichstellung in F&E und verfolgt eine umfassende Strategie, indem sie alle drei Handlungsebenen adressiert (Individuen, Institutionen, Gender als Forschungsinhalt). Dennoch zeigt die Sonderauswertung der von der FFG-geförderten Projekte insofern eine ernüchternde Bilanz bei den involvierten Unternehmen, als sich die Teilnahme von Frauen an den FFG Projekten nicht von den aggregierten Zahlen der Statistik Austria für forschungsaktive Unternehmen unterscheiden – also kein Impuls zu einer Änderung wahrnehmbar ist.
Ontologías terminológicas en la organización temática de dominios de conocimiento
Authors: Suárez Sánchez Adriana
Published: October 2022

Los dominios son campos de conocimiento con una base de saber, objetivos y usuarios. Se encuentran en la realidad, como espacios cognitivos individuales o sociales. Están “ahí”, pero para ser identificados y comunicados requieren ser explicitados. Desde la perspectiva bibliotecológica, los dominios de conocimiento han sido organizados temáticamente mediante listas de temas, tesauros y clasificaciones; sin embargo, en las últimas décadas las tecnologías de la información han aportado nuevas herramientas que están transformando la actividad. A partir de lo señalado anteriormente, el objetivo del presente artículo es analizar los alcances de las ontologías terminológicas en la organización temática de dominios de conocimiento. La metodología de investigación aplicada fue exploratoria-cualitativa y se fundamentó en dos técnicas de estudio: hermenéutica del discurso y análisis de casos. Se encontró que las ontologías terminológicas son un sistema de organización de conocimiento caracterizado por elementos conceptuales, categoriales, atributivos y relacionales que les permiten representar de manera semántica campos del conocimiento. Se concluye que son sistemas con grandes ventajas en la gestión temática de dominios: contribuyen en la clarificación terminológica y conceptual de los tópicos, posibilitan el entendimiento consensuado entre los expertos, son bases de datos comprensibles para las máquinas y pueden actuar como lenguajes documentales.
Estudio descriptivo de los resultados obstétricos y neonatales en dos modelos de asistencia al parto en primíparas
Authors: Conesa Ferrer María Belén , Camacho Ávila Marcos , Hernández Sánchez Encarnación , López Martínez Esther María , Marín Conesa Ester
Published: October 2022

Introducción: En el siglo XX el parto pasó de ser atendido en casa al ámbito hospitalario. Se adoptaron de forma acrítica intervenciones inapropiadas e innecesarias que condujeron a una deshumanización del parto. Este es el modelo que existe actualmente en la mayoría de los hospitales españoles y que fue cuestionado por la OMS ya en 1996. Objetivo: Describir las diferencias que existen en los resultados obstétricos y neonatales en primíparas en dos modelos distintos de asistencia al parto (biomédico y humanizado). Método: Se llevó a cabo un estudio descriptivo, de corte transversal. Se obtuvo una muestra por conveniencia de 205 primíparas, 110 del modelo biomédico y 95 del humanizado. Se compararon los resultados obstétricos y neonatales en dos hospitales con modelos diferentes de asistencia al parto en España. Resultados: En el modelo humanizado de asistencia al parto se obtuvieron unos mejores resultados obstétricos (inicio espontáneo, parto eutócico, periné íntegro o desgarro de I grado y menos episiotomías) que en el biomédico. No hubo diferencias en los resultados neonatales. Conclusión: Los beneficios de instaurar un modelo humanizado de asistencia al parto deberían ser considerados por los responsables de políticas sanitarias y reflejados en la mujer y su criatura.
Formulation & Development of Baclofen microemulsion incorporated into Transdermal patch
Authors: Panghal Anshul , Sachdeva Monika , Agarwal Vijay
Published: October 2022

The current study aims at developing formulations based on microemulsions for the transdermal patch of Baclofen. Castor oil was used in the oil phase, Tween-20 was used as a surfactant, propylene glycol(PG) worked as a cosurfactant, and water worked as an aqueous phase in the formation of microemulsions. Using Franz diffusion cells, in vitro permeation tests were conducted. At the conclusion of 8 hours, the in vitro permeation release of ME-3 was determined to be 88.79%, and baclofen microemulsion was later put into the transdermal patch. The most effective composition was ME-3, which included dimethyl sulfoxide as a penetration enhancer, propylene glycol as a plasticizer, and carbopol 940 as a bio-adhesive polymer. The formulation with the best penetration enhancement exhibited a 39-fold increase and contained 0.1% DMSO. It was discovered that ME-3 Patch has a 97.67% in vitro permeation release rate. According to a study, baclofen may be produced into transdermal patches with an acceptable appearance and an appropriate drug release time of 4 hours.

Keywords: (ME-)Microemulsion, HPMC, Transdermal patch, Baclofen, Carbopol- 940
Synthesis and Virtual Screening of Some Novel Quinazolinone Derivatives as Potent Cholinesterase Inhibitors against Alzheimer’s Disease
Authors: Kachhadiya Radhika , Prajapati Denish , Patel Krishna , Prajapati Navnit
Published: October 2022

In the past few decades, the cholinergic theory of Alzheimer's disease has been promoted as a crucial tool for the creation of new drugs. In this study, a series of novel quinazolinone scaffold were synthesized, docked and predicted for their ADMET studies for cholinesterase inhibitors against Alzheimer’s disease. Docking study were performed, using Autodock 4.2 for the synthesized compounds 4a-c and were observed to be well accommodated in the active site of AChE compared to standard Donepezil. Compounds 4d-f were most suggested novel quinazolinone derivative that the inhibitor exhibited two hydrogen bonding interactions with AChE. In-silico drug-likeness and pharmacokinetic properties was predicted using Swiss ADME, pkCSM software. All synthesized compounds 4a-f having better pharmacokinetic profile for potential to act as a cholinesterase inhibitors against Alzheimer’s disease.

Keywords: Alzheimer’s disease, Quinazolinone, Pharmacokinetic profile, Cholinesterase, Acetylcholinesterase (AChE).
A Review on Household Poisoning and its Management
Authors: Singh S Daniel Sundar , Das Alka M , Harshini A. , Kishore Irene Mariya , Subanandhiny S.M.
Published: October 2022

Background: Hazardous materials have become a popular home item in many developing countries over the last few decades. It has become a huge global health problem due to their simple availability, marketing, accessibility, and lack of knowledge. According to current figures, unintentional and domestic poisoning is the 13th biggest cause of mortality in India in an urban setting in India; Patil et al. (2014) identified home items to be the most common poisoning agents.

Data sources Study selection: This is a review paper. All the content in this article is taken from several reviews and guidelines published by WHO, HSRA etc.

Conclusion: To lower the prevalence of poisoning in urban settings, it is crucial to educate and raise awareness among the general public about chemical poisoning from home chemicals. Early diagnosis of suspected poisoning symptoms, implementing effective preventive measures and providing fast, focused treatment will help you win the war against poisoning in India.

Keywords: Household poisoning, WHO, Antidotes, Poison, Toxicity.
TikTok Media as an Effort to Increase Dental Health Knowledge for High School Students
Authors: RE Pudentiana Rr , Harliani Nabila Dwi , Purnama Tedi
Published: October 2022

Background: The first step in an effort to increase knowledge and prevent dental and oral health problems is to provide counseling. The success of counseling in changing target behavior is influenced by the extension media used, one of the learning media that can be used on the internet is the TikTok application. Objective: To analyze the effectiveness of TikTok media as an effort to increase dental health knowledge among students of SMAN 1 Gunung Sindur in 2022. Methods: This study used a quasi-experimental method. This research was conducted on 32 people obtained by purposive sampling technique. The instrument used in this study was a questionnaire about oral health. Analysis of the data used is a paired sample test. Results: The results of this study showed that before being given education the average was 62.66, while after education, the average was 93.91. The results of the paired sample test obtained p value = 0.000, meaning that there is a difference in knowledge before and after dental health education with TikTok media. Conclusion: TikTok media is effective in increasing dental health knowledge in high school students.

Keywords: TikTok, Education, Dental Health
Drug-Induced Liver Injury: A Literature Review
Authors: Tandon Pooja , Malhotra Meenakshi , Singh Ajeet Pal , Singh Amar Pal , Melkani Indu
Published: October 2022

Drug-Induced liver injury (DILI) is a common harmful drug reaction of some medication which can cause the damage to liver cells, or might be a chance of death. In the western countries DILI is the main cause for acute liver failure. These reactions are very common because almost all drug regimens can cause injury to liver. Most of DILI cases are harmless and they get better after stopping the offending drug. These reactions are mainly due to some pharmacological remedies, traditional medications, herbal and nutritional supplements. Due to these harmful reactions, elevation is noticed in the liver enzymes (alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphate, total bilirubin) 2N from its normal value. Drug-induced liver injury includes 1,000 of pharmacological remedies or more. Here, we review the maximum current literature, so the treatment includes timely diagnosis and removal of the doubtable medication is the key. This paper explains the different causes, pharmacological medications responsible for drug-induced liver injury, effect of covid-19 on liver injury and future perspective. It is important to be aware of and remove the suspected agent as soon as possible. There are no specific risk factors for DILI, but existing liver disease and genetic factors may be a priority for some people. Treatment of liver damage caused by drugs and herbs includes immediate drug withdrawal and supportive care aimed at alleviating unwanted symptoms. Main purpose of this paper is to deliver the info about the DILI, which are dose related, identification and consideration of disease.

Keywords: Drug-Induced liver injury (DILI), Pathophysiology, Diagnosis, Treatment, Risk factors and effect of covid-19 on liver injury.
ética policial en el marco de la ética cívica y la razón cordial
Authors: Losada-Sierra Manuel , Contreras Sarmiento Jorge Orlando
Published: October 2022

Como garante de la seguridad de los ciudadanos y de la convivencia y estabilidad de la sociedad, la institución policial requiere desarrollar una sólida formación ética en sus miembros que les permita cumplir con su misión y fortalecer las relaciones con la comunidad. El presente trabajo tiene como objetivo mostrar que el trabajo del policía debe tener una doble perspectiva: la ética cívica que organiza la vida social de los ciudadanos en las sociedades democráticas y la ética de la razón cordial que lleva al policía a entregar su vida al servicio particularmente de los más vulnerables. Usando como método un trabajo teórico de análisis-síntesis, el artículo demuestra que esta doble perspectiva permite que la labor del policía pueda desarrollarse en contextos democráticos, pero también en aquellos contextos necesitados de fortalecer mecanismos de respeto por quienes han sido víctimas. El artículo concluye que la ética cívica y la ética cordial son un complemento que puede hacer del policía un ciudadano con una autoridad entendida como servicio y como respuesta a la sociedad democrática en el que los ciudadanos son iguales ante la ley, pero además en la cual se tiene especial cuidado de quienes son más vulnerables.