bluuebunny/crossref_metadata_2025 huggingface dataset:
Investigation of Ni Catalyzed Oxygen Reduction Reaction with the Interdigitated Array Electrodes
Authors: Hao Yanan , Du Peiqi , Tao Keyu , Liang Yanping , Liu Fei
Published: July 2022

Oxygen reduction reaction is considered as the “bottleneck” of the energy storage and utilization reactions, and understanding the specific reaction pathway and mechanism are essential in designing new catalysts. Interdigitated array electrodes are special electrochemical tool for in situ measurements and have the advantage of high collection efficiency and high sensitivity, which could be utilized for the detection of the reaction intermediate. Here in this work, the nonprecious metal catalyst Ni was studied in situ towards the ORR catalytic activity with IDA electrodes. Through the electrodeposition method, the Ni catalyst was conducted with the IDA electrodes successfully. The generator-collector mode of IDA electrodes was applied so as to carry out ORR and have the reaction intermediate H2O2 being detected simultaneously. It was observed that the average electron transfer number of Ni-catalyzed ORR is about 3, and it various with the change of applied potential and the surface state of catalyst. The H2O2 production changes between 40% and 75%, reflecting the possible reaction pathway at different status. After being annealed with different temperatures, the overall catalytic current enhanced with the increase of temperature, while the average electron transfer number declined.
Study on Mechanism and Control Technology of Asymmetric Floor Heave in a Deep Soft Rock Main Roadway
Authors: He Fulian , Zhai Wenli , Xu Xuhui , Song Jiayu , Li Liang , Lv Kai
Published: July 2022

Considering the serious asymmetric deformation and failure of the floor of 1# main roadway in Wanglou Coal Mine, the mechanism of roadway asymmetric floor heave was studied through on-site investigation, theoretical analysis, numerical simulation, and on-site test. The following conclusions were drawn: (1) the floor heave of 1# main roadway is mainly caused by high original rock stress, surrounding rock stress, water physical effect, support strength, etc. (2) A mechanical model of asymmetric floor heave is built and analyzed. Roadway floor stability is relevant to the stress concentration coefficient of the roadway sides, the burial depth of the roadway, and the cohesion and internal angle of friction of the floor rock. The relationship between the upward resultant force of the floor and the stress concentration coefficient of the roadway sides is established. Affected by mining, the upward force of roadway floor reaches 17.0 MPa, and serious floor heave is easy to occur when the floor is opened. (3) The floor heave curve of the position of 1# main roadway corresponding to working face is obviously asymmetric, the maximum value of floor heave being 948 mm. The floor heave curve of other positions of 1# main roadway is basically symmetric, the maximum floor heave value being merely 497 mm. A new “differentiated” combined support is proposed and field tested. It has been 13 months since the completion of main roadway repair in this section, no obvious deformation occurred, and the long-term stability of soft rock roadway support in deep mines is realized.
Artificial Controlling of the Collinear Liberation Points Using Lorentz Force in the Restricted Three-Body Problem
Authors: El-Saftawy M.I. , Yousef M.A. , Mostafa A.
Published: July 2022

This work studies the possibility of generating artificial collinear liberation points for the planar circular restricted three-body problem using Lorentz force affecting a charged spacecraft due to the magnetic field of a planet. It is considered to be a magnetic dipole inclined by angle α with the spin axis of the planet. The acceleration components for Lorentz force are first derived in an inertial planet-center coordinate system. Then, they are transformed into the rotating coordinate system of the three-body system, with the planet naturally the smaller primary in a planet-Sun system. The equations for the liberation points are derived including the charge per unit mass as the controlling parameter. Finally, the values of the charge per unit mass required for controlling the collinear liberation point positions are derived. A numerical application for the Sun-Jupiter system is introduced and the relation between the position of the artificial liberation point and the charge per unit mass is presented graphically.
Assessment of Early Response to Lung Cancer Chemotherapy by Semiquantitative Analysis of Dynamic Contrast-Enhanced MRI
Authors: Zhu Jiang , Yun Jian , Wang Kaixiang , Liu Liangqing , Zheng Jiangang , Mei Li , Xu Jianxing
Published: July 2022

Objective. To evaluate the early chemotherapy response in patients with lung cancer using semiquantitative analysis of dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI). Methods. Twenty-two patients with lung cancer treated with chemotherapy were subjected to DCE-MRI at two time points: before starting treatment and after one week of therapy. The image data were collected by DCE-MRI, and the semiquantitative parameters including positive enhancement integral (PEI), signal enhancement ratio (SER), maximum slope of increase (MSI), and time to peak (TTP) were calculated. After chemotherapy, the parameters and relevant variations between the responders and nonresponders were compared with Mann–Whitney

U

tests. Student’s

t

-test for paired samples was used to evaluate the temporal changes between pre- and posttreatment images. Results. The patients were categorized as 13 responders and 9 nonresponders based on the tumor response evaluation. After chemotherapy, the PEI, SER, and MSI were significantly increased in responders compared with the pretreatment values (

P
<
0.05

), while no obvious decrease in TTP was observed (

P
>
0.05

). However, 9 nonresponders showed no significant changes in PEI, SER, MSI, and TTP values, as compared with those of pretreatment (

P
>
0.05

). Moreover, the increase of PEI was more dramatically in responders than in nonresponders (

P
<
0.05

), but no significantly differences were observed in SER, MSI, and TTP (

P
>
0.05

). Conclusion. Semiquantitative analysis of DCE-MRI could provide a reliable noninvasive method for assessing early chemotherapy response in lung cancer patients.
Kaleva-Seikkala’s Type Fuzzy
b
-Metric Spaces and Several Contraction Mappings
Authors: Li Shu-Fang , He Fei , Lu Shu-Min
Published: July 2022

In this paper, we introduce the concept of Kaleva-Seikkala’s type fuzzy

b

-metric spaces as a generalization of the notion of

b

-metric spaces and fuzzy metric spaces. In such spaces, we establish Banach type, Reich type, and Chatterjea type fixed-point theorems, which improve the relevant results in fuzzy metric spaces. Two technical lemmas are employed to ensure that a Picard sequence is a Cauchy sequence. Finally, various applications are given to testify the fact that our main theorems extend the cases of

b

-metric spaces.
Methylene Blue Dye Photodegradation during Synthesis and Characterization of WO3 Nanoparticles
Authors: Surakasi Raviteja , Alimuddin  , Rao Yenda Srinivasa , Sanuj Ashitha K. , Patil Pravin P. , Jayaganthan A. , Hechhu Ramana
Published: July 2022

Semiconductor-based photocatalytic systems have found widespread use in environmental pollution cleanup and renewable energy production. In this study, we synthesized WO3 as a catalyst for the degradation of methylene blue, a thiazine dye, which was used in the previous work. The hydrothermal process is used to create WO3 nanoparticles, which are made from sodium tungstate. When it comes to confirming the nanoparticles, many characterization techniques are employed, including X-ray diffraction (XRD), Fourier transform infrared (FTIR), UV-Vis diffuse reflectance spectrometer (DRS), X-ray photoelectron spectroscopy (XPS), and field emission–scanning electron microscope (FE-SEM). The existence of monoclinic crystalline structure is shown by XRD, with the average crystalline size being around 34 nm. FTIR confirms the presence of metal oxides. The pellucid absorption extremity in the UV-Vis region corresponds to the rudimentary absorption of the WO3 semiconductor. FE-SEM confirms square-shaped nanoplates with EDX address the occurrence of elemental tungsten. The photocatalytic activity of WO3 nanoparticles against methylene blue is taken for at different intervals of time that confirms MB’s degradation. Our present work suggests that prepared nanoparticles should be potential for photocatalysts using various industrial dyes.
Clinical Efficacy of Retroauricular Injection of Methylprednisolone Sodium Succinate in the Treatment of Sudden Deafness with Type 2 Diabetes
Authors: Zhong Zhenbo , Wang Xiaofei , Xu Kairui , Tao Jing
Published: July 2022

Background. The etiology of sudden deafness is still unclear. In recent years, people’s life rhythm is getting faster and faster. Fatigue, environment, diet, psychology, and other factors have increased the morbidity rate of sudden deafness and improved the quality of life of patients. And work efficiency is greatly affected. Aims. A study to investigate the clinical efficacy of postauricular injection of methylprednisolone sodium succinate in the treatment of sudden deafness with type 2 diabetes. Materials and Methods. Sixty patients with sudden deafness who were treated in our hospital from January 2018 to October 2020 were selected as the subjects of this prospective study and divided into 30 cases each in the comparison group and the observation group according to the random number remainder grouping method. The comparison group was treated conventionally, and the observation group was treated with postauricular injection of methylprednisolone sodium succinate on the basis of the comparison group. Patients in the two groups were observed and compared on the 3rd, 6th, and 9th days after treatment with pure-tone hearing threshold checks and regular monitoring of blood glucose, blood rheology, and other indexes. Results. On the 7th, 14th, and 30th days after treatment, the pure-tone audiometric thresholds of the two groups were gradually decreased, and the changes in the pure-tone audiometric thresholds in the observation group were greater than those in the control group. After lunch on the 6th day and after lunch on the 9th day, it was lower than that in the control group, and the difference was statistically significant (

P
<
0.05

). 30 days after treatment, the blood viscosity, fibrin, and platelet aggregation rate of the observation group were significantly lower than those of the control group. After treatment, the clinical efficacy rate of the observation group was 96%, which was significantly higher than that of the control group, 80%, and the above differences were statistically significant (

P
<
0.05

). Conclusion. Treatment with postauricular injection of methylprednisolone sodium succinate has shown better therapeutic recovery in patients with sudden deafness, improved pure-tone hearing threshold, reduced risk of blood glucose elevation, and improved clinical outcomes for patients with sudden deafness, providing some reference for the treatment of patients with sudden deafness.
Symptom‐Based COVID‐19 Prognosis through AI‐Based IoT: A Bioinformatics Approach
Authors: Pal Madhumita , Parija Smita , Mohapatra Ranjan K. , Mishra Snehasish , Rabaan Ali A. , Al Mutair Abbas , Alhumaid Saad , Al-Tawfiq Jaffar A. , Dhama Kuldeep
Published: July 2022

Objective. Internet of Things (IoT) integrates several technologies where devices learn from the experience of each other thereby reducing human‐intervened likely errors. Modern technologies like IoT and machine learning enable the conventional to patient‐specific approach transition in healthcare. In conventional approach, the biggest challenge faced by healthcare professionals is to predict a disease by observing the symptoms, monitoring the remote area patient, and also attending to the patient all the time after being hospitalised. IoT provides real‐time data, makes decision‐making smarter, and provides far superior analytics, and all these to help improve the quality of healthcare. The main objective of the work was to create an IoT‐based automated system using machine learning models for symptom‐based COVID‐19 prognosis. Methods. Comparative analysis of predictive microbiology of COVID‐19 from case symptoms using various machine learning classifiers like logistics regression, k‐nearest neighbor, support vector machine, random forest, decision trees, Naïve Bayes, and gradient booster is reported here. For the sake of the validation and verification of the models, performance of each model based on the retrieved cloud‐stored data was measured for accuracy. Results. From the accuracy plot, it was concluded that k‐NN was more accurate (97.97%) followed by decision tree (97.79), support vector machine (97.42), logistics regression (96.50), random forest (90.66), gradient boosting classifier (87.77), and Naïve Bayes (73.50) in COVID‐19 prognosis. Conclusion. The paper presents a health monitoring IoT framework having high clinical significance in real‐time and remote healthcare monitoring. The findings reported here and the lessons learnt shall enable the healthcare system worldwide to counter not only this ongoing COVID but many other such global pandemics the humanity may suffer from time to come.
Multimodal Neuroelectrophysiological Monitoring Combined with Robot‐Assisted Placement of a Transiliac–Transsacral Screw for the Treatment of Transforaminal Sacral Fractures
Authors: Wang Pengfei , Yang Kun , Qi Huaguang , Yan Xinan , Fei Chen , Liu Xuemei , Wei Xing , Wang Hu , Fu Yahui , Deng Hongli , Zhang Kun , Zhuang Yan
Published: July 2022

Objective. This study aimed to evaluate the safety and efficacy of the fixation of transforaminal sacral fractures using TiRobot‐assisted transiliac‐transsacral (TITS) screws under multimodal neuroelectrophysiological monitoring (MNM). Methods. From January 2019 to May 2021, 22 patients (17 male and 5 female patients) with transforaminal sacral fractures who were treated with closed reduction and placement of TiRobot‐assisted TITS screws under MNM were retrospectively evaluated. The average age of the patients was 43.32 ± 11.40 years (range: 19–63). The patients received MNM, including somatosensory‐evoked potentials (SEPs), motor‐evoked potentials (MEPs), and electromyographic monitoring (EMG), prior to surgery, during closed reduction and the placement of the guidewire and TITS screw, and at the end of surgery. The operation was adjusted according to the MNM results. Results. Overall, 22 TITS screws were inserted in 22 patients, including 5 TITS screws in the S1 body and 17 TITS screws in the S2 body. The average time needed for screw placement was 27.95 ± 6.84 mins, and the average frequency of X‐ray fluoroscopy exposures was 31.00 ± 5.56 for each patient. Anterior ring fixation was performed in 4 patients using an external fixator, in 5 patients using cannulated screws, and in 13 patients using reconstruction plates. The mean follow‐up time was 14.46 ± 2.46 months (12–20 months). Tornetta and Matta radiographic outcomes were excellent in 10 patients, good in 9 patients, fair in 2 patients, and poor in 1 patient. The proportion of excellent and good ratings was 86.36%. At the final follow‐up, the average Majeed score was 82.18 ± 14.52, with clinical outcomes that were excellent in 9 patients, good in 9 patients, fair in 1 patient, and poor in 3 patients. The proportion of excellent and good ratings was 82.82%. Preoperatively, the amplitude of the SEP on the injured side was lower than that on the contralateral side before reduction in 9 patients (>50%). In this study, no screw was mistakenly inserted into the sacral canal, and no surgical site infection occurred. Conclusion. MNM combined with TiRobot assistance can safely implant TITS screws and can effectively identify the neurological function of patients under anesthesia and reduce iatrogenic nerve injury.
Trace and Rare Earth Element Partitioning in Organic Fractions of Mudstones during the Oil Formation
Authors: Gao Ping , Li Boyuan , Xiao Xianming
Published: July 2022

In order to investigate trace and rare earth element partitioning in organic fractions of mudstones, this study isolated organic fractions of mudstones, including insoluble organic fraction (kerogen), soluble organic fraction (extract), or expelled hydrocarbon (reservoir solid bitumen), and the isolated organic fractions and their corresponding whole rocks for trace and rare earth element compositions were measured. Analysis of trace and rare earth element compositions in organic fractions of lacustrine and marine mudstones revealed that mudstone kerogens were more enriched in rare earth elements (REE) and redox-sensitive trace elements (e.g., U, Mo, and Ni) relative to corresponding whole rocks. During the oil generation, middle rare earth elements (Sm-Ho), especially Eu, migrated from kerogen to extract more easily than the rest REE. The Eu was easily transferred to soluble hydrocarbon under the acidic and reducing environments formed by oil generation, resulting in the higher concentrations of Eu relative to its neighboring REE (Sm and Gd) and the pronounced positive Eu anomalies. Transition metal elements (e.g., Mo, V, Cr, Co, Ni, Cu, and Zn) also more easily released from kerogen than the rest elements, especially V and Ni. The enrichment and mobilization of trace elements in organic fractions of mudstones, such as Mo, U, V, Ni, and Ba, are closely related with their geochemical behaviors during the depositional and early digenetic processes, providing the potential information for predicting the distribution characteristics of trace elements in the expelled hydrocarbons of mudstones (e.g., crude oil and solid bitumen) and fingerprinting of oil to source.
Anti‐inflammatory and Immunomodulatory Properties of Lepidium sativum
Authors: Vazifeh Saeid , Kananpour Parya , Khalilpour Mahna , Eisalou Sajjad Vazifeh , Hamblin Michael R.
Published: July 2022

Background. Lepidium sativum (garden cress) is a member of the Brassicaceae family that has been utilized for medicinal and culinary purposes in centuries. Anti‐inflammatory, antioxidant, immunomodulatory, hepatoprotective, antihypertensive, antiasthmatic, and hypoglycemic properties are found in various portions of the plant. The anti‐inflammatory, antioxidant, and immunomodulatory effects of L. sativum were the subject of this review. Methods. The required information was gathered by searching the Web of Science, PubMed, and Scopus databases for the terms anti‐inflammatory, antioxidant, immunomodulatory, immune system, and Lepidium sativum. Up until February 2022, the search was conducted. Results. TNF‐, IL‐6, IL‐1, NO, iNOS, and HO‐1 levels were reduced, indicating that L. sativum has anti‐inflammatory and immunomodulatory properties. Flavonoids, alkaloids, cyanogenic glycosides, tannins, glucosinolates, sterols, and triterpenes are the key chemical components that contribute to the anti‐inflammatory effects. In peritoneal neutrophils, L. sativum reduced oxidative stress by scavenging free radicals, as evidenced by a drop in superoxide anion and an increase in glutathione. Conclusion. The anti‐inflammatory, antioxidant, and immunomodulatory activities of L. sativum could be explored in clinical trials to treat inflammatory and immune system illnesses.
An Energy Metabolism Study on the Efficacy of Naoxintong Capsules against Myocardial Infarction in a Rat Model
Authors: Zhao Jie , Ouyang Yi , Wang Huanhuan , Lai Huaqing , Hu Shaowei , Tang Liying , Yang Hongjun , Wu Hongwei
Published: July 2022

Background. In myocardial ischemia, optimizing the myocardial metabolic phenotype to improve cardiac function is critical. Naoxintong capsules (NXT) are widely prescribed in Chinese medicine for the treatment of cerebrovascular and cardiovascular diseases. Methods. In this study, a rat model of myocardial infarction was established by ligation of the left anterior descending coronary artery. The structure and function of the heart were evaluated using echocardiography. The pathological changes of the rat myocardium and the myocardial volume collagen fraction (CVF) were examined using hematoxylin-eosin (HE) and Masson’s trichrome staining (Masson). The expression of TNF-α and IL-6 were detected by immunohistochemistry. The level of cTnT was also measured to evaluate myocardial injury. In order to study the changes in energy metabolism in myocardial infarction and the effects of NXT, a targeted analysis method for detecting the 29 energy metabolites in cardiac muscle tissue was developed based on UPLC-QQQ-MS. Western blotting was used to detect the expression of proteins related to energy metabolism in myocardia. Results. In the rat model of myocardial infarction, NXT showed obvious effects, such as improving heart function and increasing LVEF and LVFS. HE staining, Masson staining, and immunohistochemical results revealed that NXT decreased inflammatory infiltration, improved myocardial fibrosis, and reduced infarct size. In addition, NXT significantly reduced the level of serum cTnT. The levels of the 29 energy metabolites in cardiac muscle tissue were analyzed using a newly developed targeted analysis method. Compared to the sham group, the levels of 17 metabolites from different energy metabolic pathways, including four compounds in glycolysis metabolism, four compounds in TCA cycle, three compounds in oxidative phosphorylation, four compounds in purine metabolism, and two compounds in glutathione metabolism, displayed obvious changes induced by myocardial ischemia. Expressions of SIRT1, PGC-1α, and ATP5D proteins related to energy metabolism were decreased after myocardial infarction. These perturbations could all be reversed by NXT intervention, suggesting that the therapeutic effects of NXT were partially due to interferences with energy metabolisms. Conclusion. This study provides a useful approach for investigating the mechanism of myocardial infarction and evaluating the efficacy of NXT from energy metabolism.
International Logistics Management System Based on Cloud Computing Technology
Authors: Fan Ming
Published: July 2022

In order to solve the problems of slow matching between supply and demand, information authenticity and security, and lack of trust in traditional logistics platforms, the author proposes an international logistics management system based on cloud computing technology. The system uses blockchain as the underlying technology, combined with related technologies such as smart contracts and NSGA-II algorithms, matches the supply and demand sides of cross-border logistics resources, writes the important information generated in the platform transaction into the blockchain, and carries out network-wide broadcast and consensus, so as to realize the intelligence of the transaction and the nontampering and traceability of the information. The experiment found that in the case set by this example,

max

Z

1

=
57.139

, and

max

Z

2

=
54.679

, meaning that the final matching result is as follows: P2, the cross-border logistics provider, is matched with U5, the consignor; P3 matches U9, P8 matches U4, P9 matches U3, P1 matches U6, P5 matches U1, P7 matches U2, P4 matches U7, P10 matches U8, and P8 matches U10. Satisfactory matching results show that the algorithm is effective. Experimental results show that the system can increase the transparency and sharing of cross-border logistics information, help to reduce forged data information, improve the level of automation and intelligence, and provide a reference for the application of blockchain technology in the field of cross-border logistics.
Mechanism of Danhong Injection in the Treatment of Arrhythmia Based on Network Pharmacology, Molecular Docking, and In Vitro Experiments
Authors: Yu Tingting , Li Yuxin , Yan Meihui , Zhang Zhang , Yuan Xin , Li Sen
Published: July 2022

Background. Danhong injection (DHI) is widely used in the treatment of cardiovascular and cerebrovascular diseases, and its safety and effectiveness have been widely recognized and applied in China. However, the potential molecular mechanism of action for the treatment of arrhythmia is not fully understood. Aim. In this study, through network pharmacology and in vitro cell experiments, we explored the active compounds of DHI for the treatment of arrhythmia and predicted the potential targets of the drug to investigate its mechanism of action. Materials and Methods. First, the potential therapeutic effect of DHI on arrhythmia was investigated in an in vitro arrhythmia model using human induced pluripotent stem cell‐derived cardiomyocytes (hiPSC‐CMs), in which calcium transients were recorded to evaluate the status of arrhythmia. Next, the active compounds and key targets in the treatment of arrhythmia were identified through network pharmacology and molecular docking, and the key signaling pathways related to the treatment of arrhythmia were analyzed. Furthermore, we used real‐time quantitative reverse transcription PCR (qRT–PCR) to verify the expression levels of key genes. Results. Early afterdepolarizations (EADs) were observed during aconitine treatment in hiPSC‐CMs, and the proarrhythmic effect of aconitine was partially rescued by DHI, indicating that the antiarrhythmic role of DHI was verified in an in vitro human cardiomyocyte model. To further dissect the underlying molecular basis of this observation, network pharmacology analysis was performed, and the results showed that there were 108 crosstargets between DHI and arrhythmia. Moreover, 30 of these targets, such as AKT1 and HMOX1, were key genes. In addition, the mRNA expression of AKT1 and HMOX1 could be regulated by DHI. Conclusion. DHI can alleviate aconitine‐induced arrhythmia in an in vitro model, presumably because of its multitarget regulatory mechanism. Key genes, such as AKT1 and HMOX1, may contribute to the antiarrhythmic role of DHI in the heart.
Biological Activities Underlying the Therapeutic Effect of Quercetin on Inflammatory Bowel Disease
Authors: Lyu Yong-Li , Zhou Hai-Feng , Yang Jia , Wang Fa-Xi , Sun Fei , Li Jun-Yi
Published: July 2022

Inflammatory bowel disease (IBD) is a chronic autoimmune disorder stemming from unrestrained immune activation and subsequent destruction of colon tissue. Genetic susceptibility, microbiota remodeling, and environmental cues are involved in IBD pathogenesis. Up to now, there are limited treatment options for IBD, so better therapies for IBD are eagerly needed. The therapeutic effects of naturally occurring compounds have been extensively investigated, among which quercetin becomes an attractive candidate owing to its unique biochemical properties. To facilitate the clinical translation of quercetin, we aimed to get a comprehensive understanding of the cellular and molecular mechanisms underlying the anti-IBD role of quercetin. We summarized that quercetin exerts the anti-IBD effect through consolidating the intestinal mucosal barrier, enhancing the diversity of colonic microbiota, restoring local immune homeostasis, and restraining the oxidative stress response. We also delineated the effect of quercetin on gut microbiome and discussed the potential side effects of quercetin administration. Besides, quercetin could serve as a prodrug, and the bioavailability of quercetin is improved through chemical modifications or the utilization of effective drug delivery systems. Altogether, these lines of evidence hint the feasibility of quercetin as a candidate compound for IBD treatment.
The Study of Virtual Reality Sensing Technology in the Form Design and Perception of Public Buildings
Authors: Li Leili , Zheng Xinyu
Published: July 2022

In order to explore the commercial building design method that meets the needs of contemporary consumer behavior, the author proposes a method of applying virtual reality, behavior simulation, and other technologies to commercial building design. First, through a questionnaire survey of commercial buildings in a city, the influencing factors of consumption behavior are explained with the help of SPSS correlation analysis. Then, applying virtual reality technology on this basis, three-dimensional presentation of the commercial building design scheme, taking the design of commercial space signage system as an example, the preset low-brightness color system, and the color and shape are single, the logo set A and the logo set B using high-brightness color system and changeable form are presented, expand 3D dynamic visual and behavioral simulations. At last, relying on ResNet image recognition technology, it analyzes the user’s visual experience and usage effect. Experimental results show: There is a significant correlation between plane layout, spatial identification, familiarity of indoor space, and frequency of use, and visual perception is the main driving factor for choosing commercial buildings; using the comparative analysis of commercial logos, it is found that the average value of the confidence of set B is less than that of set A; in terms of significance, the average time of identifying all categories of logo set A is 0.68 s, and the average identification time of all categories of identification set B is 0.46 s; in terms of discrimination, it takes 0.28 s to correct the misrecognition of all categories of identification set A and 0.11 s to correct the misrecognition of all categories of identification set B, indicating that the design of the identification system uses bright colors and changeable forms, which are easier to use. The results indicate that the elevation, slope, hydrology, transportation conditions, economic indexes and cultural factors are important factors affecting the spatial distribution of traditional villages in a city. The analysis shows that the distribution of traditional villages is affected by natural conditions, social economic conditions, cultural factors and other factors, and the optimal layout of traditional villages can be strengthened from these aspects.
Clinical Manifestations, Imaging Features, and Pathogenic/Prognostic Risk Factors for Temporomandibular Disorders (TMD): A Case-Control Study Based on Psychogenic Factors of Patients
Authors: Hu Sunqiang , Shao Zhenghao , Deng Lichao
Published: July 2022

Objective. To survey the clinical manifestations and imaging features of temporomandibular disorders (TMD) and analyze the risk factors for pathogenesis/prognosis through a case-control study based on psychogenic factors of patients. Methods. According to the inclusion criteria, 200 adult patients were randomly enrolled from the maxillofacial department of our hospital from January 2020 to May 2021, including 100 patients with TMD as the study group and 100 healthy patients as the control group. The study group can be assigned into four subgroups according to their clinical manifestations: (1) articular area or/and masticatory muscle pain group, (2) mandibular movement abnormality group, (3) joint murmur group, and (4) two or more symptom groups. Based on the study of psychogenic factors of patients, the clinical manifestations and imaging features of TMD were determined, and the risk factors for pathogenesis/prognosis were analyzed. Results. The distribution of psychological status in the TMD group was higher than that in the control group (

P
<
0.05

). The distribution of anxiety, depression, and somatic symptoms in the TMD group was significantly different from that in the control group (

P
<
0.05

). Anxiety, depression, and somatic symptoms were the risk factors for TMD. Compared with the control group, the incidence of abnormal MRI images in patients with temporomandibular disorders was significantly different (

P
<
0.05

). There were significant differences in psychological status (anxiety, depression, and somatic symptoms) among the three groups (

P
<
0.05

). Anxiety, depression, and somatic symptoms were the risk factors for abnormal mandibular movement and joint tremor and murmur (

P
<
0.05

). Somatic symptoms were the risk factors for various clinical symptoms of TMD (

P
<
0.05

). Depression was the risk factor for pain (

P
<
0.05

). Conclusion. In patients with TMD, MRI can early identify disc abnormalities and other related imaging features, which is helpful for more comprehensive clinical evaluation and treatment of TMD patients. There exhibits no significant difference in psychological status (anxiety, depression, and somatic symptoms) of patients with different clinical symptoms, and abnormal psychological status may be one of the risk factors leading to different clinical symptoms and development of different types of TMD patients.
Image 3D Reconstruction and Interaction Based on Digital Twin and Visual Communication Effect
Authors: Wang Yuhang
Published: July 2022

With the continuous development of multimedia technology and electronic information technology, the application of 3D images has become more and more extensive, and 3D reconstruction and interactive technology have also received more and more attention from researchers. Digital twin (DT for short) is a technology that makes full use of digital twin models and real-time monitoring data to complete real-time mapping of the real world in the digital world. Visual communication (CV for short) design is a design that is expressed and communicated to the audience through a visual medium. 3D reconstruction refers to the mathematical process and computer technology that uses 2D projection to recover 3D information of an object. This essay aims to study an image 3D reconstruction and interaction method based on DT and CV and analyze the practical feasibility and practical effect of this method. This essay proposes a model for image 3D reconstruction and interaction, which combines DT and CV effects and conducts a system simulation test for the model. The simulation is carried out on the three-dimensional reconstruction of the craniomaxillofacial area in medicine, and the reconstruction process is relatively smooth. And the final simulation test shows that the maximum CPU usage rate of the system during the rebuilding process is about 50%, which is relatively stable. The average CPU usage is about 30%, the overall system energy consumption is low, the lower limit of the overall SNR of the image is 57, and the upper limit is 62. The image quality of the reconstruction process is good, and the overall system reliability is high, which is feasible.
A Novel Modulation Technique with Low PAPR for 5G-IoT Systems
Authors: Sun Junchao , Chen Buyu , Huang Ding , Wang Baobing , Xiang Tian , Kong Dejin
Published: July 2022

For existing orthogonal frequency division multiplexing (OFDM) in 5G internet of things (5G-IoT) systems, one of the critical problems is the high peak to average power ratio (PAPR), which seriously degrades the energy efficiency. To this end, we propose a novel modulation technique with low PAPR for IoT systems, which preserves the advantage of low implementation complexity and ability to fight against multipath channels. The key methodology is the employment of symbol repetition in the frequency domain. Hence, by designing the appropriate phase factors on the repeated symbols, the PAPR of transmitted signals is equivalent to that of an OFDM signal with a reduced size of discrete Fourier transform (DFT). It is demonstrated that, even if there exists repetitive symbols, the proposed method can still maintain an unreduced spectral efficiency performance. Moreover, to evaluate the proposed method, the Monte-Carlo simulations are conducted for the complementary cumulative distribution function (CCDF) and the bit error rate under multipath fading channels. The simulations show that, as

CCDF
=

10

−
3

, the proposed method can achieve 2.5 dB gains about the PAPR compared with the original OFDM signal.
An Electrochemical-Based Point-of-Care Testing Methodology for Uric Acid Measurement
Authors: Zhao Yuetong , Song Xia
Published: July 2022

Point-of-care technology (POCT) is an important method in clinical testing in the future, which can achieve the purpose of rapid analysis. In this work, we assembled an electrochemical POC sensor for uric acid (UA) by surface modification of a screen-printed electrode. Copper nanowires were used as electrode modifiers to achieve high-performance electrochemical oxidation of UA. This electrochemical sensor can achieve linear detection of UA in the range of 10 μM to 2 mM. The detection limit of the sensor was calculated to be 2 μM. Although the detection performance of this sensor is not competitive with high-performance electrochemical sensors, it has been able to meet the needs of POC detection. At the same time, the sensor has excellent anti-interference performance. It has also been used successfully to test urine and serum samples from healthy and gout patients.
The Resource Potential and Development Prospect of Helium in Changqing Gas Field
Authors: Wang Dahai , Li Jinbu , Yu Zhanhai , Zhang Ji , Liu Lili , Xiao Feng , Shan Changan
Published: July 2022

Helium, a rare gas widely applied in high-tech fields, is a significant strategic resource in China. The foreign-trade dependence ratio of helium in China is 95%. The work reviewed the applications and market analysis of helium and reservoir modeling and distribution of helium in Changqing Gas Field as well as the helium extraction techniques from natural gases. According to the analysis of the component test and the dynamic monitoring of exploited gas wells and gas-gathering stations, the average helium content in Changqing Gas Field was 0.028%. Helium was rich in the northwest of Changqing Gas Field, but poor in the central and eastern regions. The helium volume contents in Qingyang Gas Field, Huanglong Gas Field, and the central, western, and southern regions of Sulige Gas Field have reached the industrial development standard. PetroChina performed the economic-feasibility evaluation and production-factor matching research on helium development and selected Changqing Gas Field as the demonstration for development. A large helium plant was established in Changqing Gas Field using the cryogenic method with/without membrane separation for helium extraction. Then, a helium development scheme was formulated and implemented to build the industry chain of helium in China. Changqing Gas Field is rich in helium resources. Developing helium has entered a strategic period with the technological advancement in extracting helium from natural gases and the increased prosperity of the international helium market. There are broad prospects and great benefits to exploiting helium resources in Changqing.
[Retracted] Hui Medicine Moxibustion Promotes the Absorption of Lumbar Disc Herniation and the Recovery of Motor Function in Rats through Fas/FasL Signaling Pathway
Authors: Xu Jianfeng , Luo Qiang , Song Junyao , Zhang Yanming , Wang Yingxu , Yang Lei , Sha Yinyin , Sun Bowen , You Na , Tian Xinbao , Lin Ruizhu , Wu Yongli
Published: July 2022

Objectives. To study the resorption of the herniated lumbar disc (RHLD) and its mechanism in the SD rats of lumbar intervertebral disc herniation treated with Hui medicine moxibustion (HMM). Methods. Forty SD rats were randomly divided into four groups, normal group, lumbar disc herniation (LDH) group, HMM group, and antagonist (HMM+Met12) group, with 10 rats in each group. The rat model of LDH was prepared with the method of lumbar epidural emplacement of the caudal intervertebral disc. In the HMM group and HMM+Met12 groups, 4 weeks after modeling, HMM therapy was performed in the lumbar spine for 3 months with 1 time per day and 20 min each time, the samples were collected 8 weeks after the treatment. The histological degeneration was observed through HE staining, and the neovascularization of intervertebral disc tissues was detected by the expression of CD34 and vascular endothelial growth factor (VEGF). The apoptosis of nucleus pulpous cells was detected by TUNEL assay, and the activity of caspase‐3, ‐8, and ‐9 and extracellular matrix enzymes was detected by western blotting. Results. HMM treatment significantly improved the behavioral ability of rats with LDH surgery. The morphological structure was obviously destroyed in the LDH group, but disc structure was significantly repaired in the HMM group, and mild structure alterations were observed in the HMM+Met12 group. Higher levels of CD34 and VEGF were detected in the HMM group indicating that neovascularization is formed. The expression level of FasL was significantly increased in the HMM group. The protein expression levels of cleaved‐caspase‐3, cleaved‐caspase‐8, and cleaved‐caspase‐9 in nucleus pulposus (NP) tissues were also elevated when treated with HMM, and the TUNEL staining showed the same results. The protein expression levels of matrix metalloproteinases‐ (MMP‐) 1, MMP‐2, MMP‐3, MMP‐13, and ADAMTS‐4 were markedly promoted in the HMM group. Met12, a small peptide antagonist of FasL, significantly reduced the effects of HMM. Conclusion. HMM can promote the formation of neovascularization of lumbar intervertebral disc, support the apoptosis of NP cells through Fas/FasL signaling, and regulate the degradation of extracellular matrix enzyme, which then accelerates the absorption of lumbar intervertebral disc herniation and the recovery of motor function in rats.
Synaptic Secretion and Beyond: Targeting Synapse and Neurotransmitters to Treat Neurodegenerative Diseases
Authors: Wei Ziqing , Wei Mingze , Yang Xiaoyu , Xu Yuming , Gao Siqi , Ren Kaidi
Published: July 2022

The nervous system is important, because it regulates the physiological function of the body. Neurons are the most basic structural and functional unit of the nervous system. The synapse is an asymmetric structure that is important for neuronal function. The chemical transmission mode of the synapse is realized through neurotransmitters and electrical processes. Based on vesicle transport, the abnormal information transmission process in the synapse can lead to a series of neurorelated diseases. Numerous proteins and complexes that regulate the process of vesicle transport, such as SNARE proteins, Munc18-1, and Synaptotagmin-1, have been identified. Their regulation of synaptic vesicle secretion is complicated and delicate, and their defects can lead to a series of neurodegenerative diseases. This review will discuss the structure and functions of vesicle-based synapses and their roles in neurons. Furthermore, we will analyze neurotransmitter and synaptic functions in neurodegenerative diseases and discuss the potential of using related drugs in their treatment.
Inhibition of c-MYC-miRNA 19 Pathway Sensitized CML K562 Cells to Etoposide via NHE1 Upregulation
Authors: Cao Shannan , Xiong Qingqing , Ding Bowen , Wang Xu , Wei Feng , Sun Qian , Yang Fan , Luo Jing , Chang Guoqiang , Li Suxin , Wang Jian
Published: July 2022

As a previously discovered target of DNA damage, Na+/H+ exchanger 1 (NHE1) plays a role in regulation of intracellular pH (pHi) through the extrusion of intracellular proton (H+) in exchange for extracellular sodium (Na+). Its abnormal expression and dysfunction have been reported in solid tumor and hematopoietic malignancies. Here, we reported that suppression of NHE1 in BCR-ABL+ hematopoietic malignancies’ K562 cells treated with Etoposide was manipulated by miR-19 and c-MYC. Inhibition of miR-19 or c-MYC enhanced the expression of NHE1 and sensitized K562 cells to Etoposide in vitro. The in vivo nude mouse transplantation model was also performed to confirm the enhanced sensitivity of K562 cells to Etoposide by inhibiting the miR-19 or c-MYC pathway. TCGA analysis conferred a negative correlation between miR-19 level and leukemia patients’ survival. Thus, our results provided a potential management by which the c-MYC-miRNA 19 pathway might have a crucial impact on sensitizing K562 cells to Etoposide in the therapeutic approaches.
Experimental Study on the Mechanism of Cinnamaldehyde Ameliorate Proteinuria Induced by Adriamycin
Authors: He Dan , Li Qiang , Du Guangli , Chen Shaoli , Zeng Puhua
Published: July 2022

Objective. Cinnamaldehyde (CA) is the main active component of Guizhi (Cinnamomi ramulus) to ameliorate adriamycin‐ (ADR‐) induced proteinuria in rats. However, the underlying mechanism of CA against proteinuria remains unclear. The aim of this study was to investigate the action mechanisms of CA to treat proteinuria. Methods. 13 rats were randomly selected from 78 SD rats as control group, and the other rats were injected with ADR (3 mg/kg/time) twice through tail vein on day 1 and day 8 for modeling. After modeling, the rats were randomly divided into 5 groups as follows: ADR group, ADR+CA low‐dose group, ADR+CA middle‐dose group, ADR+CA high‐dose group and Benazepril group with 13 rats in each group. The urine of SD rats was collected for 24 h, urine protein, creatinine and urea nitrogen were detected, renal index was calculated, and HE staining and western blot were performed. Results. The 24 h urine volume and urine protein, renal function, and renal histopathology got worse significantly in the ADR group. To western blot, CA downregulated the protein expression of ACE and Ang‐2 and upregulated the protein expression of ACE2 in RAS signaling pathway. Conclusion. The underlying action mechanism of CA to treat NS might mainly be achieved by regulating RAS signaling pathway.
Wound Healing Properties and Antimicrobial Effects of Parkia clappertoniana Keay Fruit Husk Extract in a Rat Excisional Wound Model
Authors: Kuma Dominic Nkwantabisa , Boye Alex , Kwakye-Nuako Godwin , Boakye Yaw Duah , Addo Justice Kwaku , Asiamah Ernest Amponsah , Aboagye Eugene Agyei , Martey Orleans , Essuman Mainprice Akuoko , Atsu Barku Victor Yao
Published: July 2022

Background. Parkia clappertoniana Keay (Family: Fabaceae) (P. clappertoniana) fruit husk is commonly used in northern Ghana for wound treatment. However, this folk claim remains to be confirmed scientifically. Objective. This study investigated wound healing and antimicrobial effects of P. clappertoniana fruit husk extract (PCFHE) by using excision wound model in rats. Materials and Methods. After preparation and phytochemical analysis of PCFHE, it was reconstituted in purified water and emulsifying ointment yielding a wound healing formula (0.3, 1, and 3%). Excision wounds were established in healthy male Sprague‐Dawley rats (aged 8‐10 weeks; weighing 150–200 g). Rats were randomly assigned into six groups (model, 1% silver sulfadiazine [SSD], vehicle, and PCFHE [0.3, 1, and 3%, respectively]) and topically treated daily until complete wound healing. The endpoints (period of epithelialization, wound contraction, collagen content, erythema index, oedema index, inflammatory cell infiltration, and antimicrobial activity) were assessed for all groups. Minimum fungicidal concentration (MFC), minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC), and time‐kill were assessed. Results. Quercetin and catechin were detected in PCFHE. Compared to model and vehicle groups, PCFHE‐treatment groups improved wound healing and antimicrobial (MBC, MFC, and MIC) endpoints. PCFHE demonstrated bacteriostatic and fungicidal effects against identified wound contaminants (Pseudomonas aeruginosa, Klebsiella pneumoniae, Escherichia coli, and Candida albicans). Conclusion. P. clappertoniana fruit husk possesses wound healing and antimicrobial effects in excisional wounds in rats that confirms its folk use, and the reported pharmacological properties of PCFHE are attributable to its quercetin and catechin phyto‐constituents.