bluuebunny/crossref_metadata_2025 huggingface dataset:
Methodical Approach to Assessment of Resource Provision of Innovative Development of Industrial Enterprise
Authors:   Odesa Polytechnic State University, Dyskina Anastasia , Kaftan Alina ,   Odesa Polytechnic State University
Published: August 2023

The article uses the system of evaluation of resource provision of innovative development on the example of an industrial enterprise. The competitiveness of the products of the investigated enterprise was calculated. An assessment of the innovation potential of PJSC "Element". The calculation of the level of innovative development of the researched enterprise is made. The organizational and economic measures on activization of innovative potential of the industrial enterprise are offered. Indicators of innovation activity of PJSC "Element" are calculated and conclusions on further strategy of the enterprise are given. A list of problems of economic support of innovative development of PJSC "Element" was formed and each of the problems was assessed by expert methods from 0 to 10 to better understand which of the identified problems are the most acute and require immediate response.
Attracting foreign investment in the country's economy: prospects for government regulation
Authors:   Odesa Polytechnic State University, Kudryavtseva Mariia , Lypynska Olena ,   Odesa Polytechnic State University
Published: August 2023

The article considers the issue of attracting international investments to various spheres of Ukraine's economy, mechanisms of state regulation of investment inflows, studies the investment climate in general, identifies the most promising areas for investment and suggests ways to improve the investment management mechanism.
Modeling of strategy of development of the production enterprise in the conditions of diversification
Authors:   Odesa Polytechnic State University, Niekrasova Liubov , Yezerova Maryna ,   Odesa Polytechnic State University
Published: August 2023

Necessary and sufficient conditions for diversification are considered. The influence of diversification processes on the efficiency of the enterprise and its potential growth on the basis of synergetic combinations of competencies and resources is determined. The scheme of modeling of process of formation of strategy of diversified development of the industrial enterprise is developed. A model of "investor portfolio analysis" adapted to diversification strategies is proposed, which allows to determine both efficiency and quantitative risks in production diversification tasks that may accompany the proposed diversification, as well as to determine the optimal production program of diversified products that corresponds to existing diversified products. market structure and enterprise capabilities.
Analysis of the definition of "corporate social responsibility"
Authors:   Odesa Polytechnic State University, Prodius Oksana , Ajaba Salma ,   Odesa Polytechnic State University, De Jesus Mateus Pessoa Jeciliano ,   Odesa Polytechnic State University
Published: August 2023

The article presents a theoretical generalization of scientific approaches to determining the nature, basic principles and methods of corporate social responsibility in modern business conditions. The components of corporate social responsibility and their impact on the functioning of the enterprise and on meeting social needs are studied. It is proved that the continuation of globalization processes and access to international markets require enterprises to have open and transparent social responsibility of business, based on the recognition of the state and business entities as equal partners in solving many economic, environmental and social problems.
Assessment of total peroxidase activity and its relationship with vitamin D in Iraqi rheumatoid arthritis patients
Authors: Hasan Hathama Razooki , Hwaidi Ahmed Qasim
Published: August 2023

Objective: In a previous work carried on in our laboratory, a positive correlation were recorded between different levels of vitamin D and the antioxidant status in Iraqi patients with rheumatoid arthritis, meanwhile some of peroxidases family have been known to act as antioxidant. Therefore in order to look for the molecular level of this action of vitamin D, the impact of different vitamin D levels on peroxidases activity in Iraqi rheumatoid arthritis patients was investigated. Method: The study included 119 patients with rheumatoid arthritis (who were matched in age range and body mass index range). Vitamin D was measured by Roche Elecsys vitamin D total II assay, total peroxidase activity was measured by Song's method and total protein was determined by biuret method. Results: The studied participants in this study were divided into four groups according to their vitamin D levels into: G1 (n=31), G2 (n=30), G3 (n=30) and G4 (n=28), through -out the present study group G4 was used as a control for the comparison purpose. The results indicated that total peroxidase activity and specific activity were highly significantly increased (p<0.001) in patients with severe deficient vitamin D level (G1), and were significantly increased (p<0.05) and highly significantly increased (p<0.001) respectively in patients with deficient vitamin D level (G2). While peroxidase activity and specific activity did not show a significant increase (P>0.05) in patients with insufficient vitamin D level (G3). Conclusion: In rheumatoid arthritis patients, vitamin D level affects peroxidases activity, as concluded from the negative counterbalance relationship that was found between the level of vitamin D and peroxidases activity.
Vipareeta Avipareeta Swapna Nidarshaneeyam chapter of Sushruta Sutra Sthana - an explorative study
Authors: Mamidi Prasad , Gupta Kshama
Published: August 2023

Vipareeta Avipareeta Swapna Nidarshaneeyam (VASN) is the 29th chapter of Sutra Sthana of Sushruta Samhita. This chapter has 81 verses that deal with various Shakunas (omens), Doota (caregiver) and Swapna (dreams). The aim of the present work is to provide a comprehensive and critical analysis of the contents of VASN chapter with the help of contemporary prognostic and dream literature. Characteristic features of a caregiver and their influence on patient’s clinical outcome, various omens (both good and bad) and dreams (both auspicious and inauspicious) and their positive or negative prognostic consequences are documented in the VASN chapter. Shakunas of the VASN chapter denote the belief systems that were prevalent in ancient India and the prognostic significance needs to be evaluated further. Interpretation of dreams that are documented in VASN chapter seems to be congruent with the findings of contemporary dream research. Interdisciplinary studies among Ayurveda, Jyotishya Shastra (medical astrology) and modern prognostic science are required to authenticate the good and bad omens and their association with the positive or negative clinical outcomes.
Intraosseous meningioma of the orbital roof
Authors: Cruz Díaz Miguel Ángel , Camacho-Gómez Ángel Serafín , Artiles Rivero Carlos Javier , Sarduy Arana Ramón
Published: August 2023

Primary intraosseous meningioma is a rare variety of meningioma that represents about 1% of all meningiomas Intraosseous or intradiploic meningioma of the pediatric orbital roof is reported in case reports in very isolation.. The following article is carried out with the objective of describing a case of primary intraosseous meningioma of orbital roof in a pediatric patient as well as reviewing the literature in this regard. It was concluded that intraosseous or intradiploic meningioma of the orbital roof is a rare entity. They are more frequent in males and the common age of presentation is at the beginning of the second decade of life. They usually only present with ipsilateral proptosis, without impaired visual acuity or pain. Most are histologically of the psammomatous variety and the treatment of choice is total surgical excision.
Skin barrier in veterinary allergy or the animal [and human] skin protective hat
Authors: Ferreira Matias Daniela , Carrilho Paixão Ana Raquel , Martins Luís
Published: August 2023

A main reason for veterinary consultation is related to dermatological conditions, with pruritus as a frequent complaint. Allergic-based Inflammatory conditions with several complications, such as alopecia and secondary infections, are common. Besides the immune-mediated triggering factors, assessment of the skin barrier, aiming restoring its effect stands essential. Defects in skin lipid and protein constitution are among human and animal skin barrier-impairing causes, favoring a deep penetration of different agents. Allergen and microorganism deep-skin penetration triggers an immune response, frequently associated to inflammation and itching, which may be enhanced by a genetic predisposition to sensitization and allergy. Human and dog skin show several constitutional similarities that have been identified as relevant for the barrier condition, which may influence both species susceptibility for allergy development and may allow for a two-way Human-dog model as both share the same environment, with the same exposome.
Factors influencing precision of determination of thermal parameters of textile fabrics
Authors: Hes Lubos , Unmar Roshan , Rosunee Satyadeo
Published: August 2023

Published data of thermal conductivity of particularly natural textile materials can be incorrect, due to uneasy way of testing of this parameter. Moreover, these data can be strongly affected by moisture of these materials. In the paper, the mentioned and other factors, which reduce the precision of thermal insulation and thermal contact properties of textile fabrics are presented and discussed.
Involvement of knee and foot pathology presenting as an accompanying sign in a soldier of synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome
Authors: Guo Chia-Yuan , Hsu Hsuan-Hsuan , Lai Chia Ying , Chang Shin-Tsu
Published: August 2023

Synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome is expressed as chronic multifocal osteomyelitis. There is no report to show a knee/foot lesions accompanying with SAPHO syndrome. We herein present a case of SAPHO syndrome with involvement of pathology of knee and foot, which was confirmed by obtaining the images of skeletal scintigraphy. We also described the clinical indicators and imaging features.
Psychological impact of the pandemic of covid-19
Authors: Aggarwal Rashmi , Aggarwal Hemant
Published: August 2023

The pandemic of covid -19, caused by the Severe Acute Respiratory Syndrome Corona Virus 2(SARS-CoV-2) is not just a grave physical health crisis but it has caused significant mental health issues as well. The aim of this paper is to assess the psychological impact of the pandemic of COVID-19. In order to reduce the community transmission of the disease, countries across the world imposed lockdowns, schools were closed, infected people were isolated and other strict measures were taken to ensure social and physical distancing. These measures induced stress, anxiety tension and depression in communities. As a result lot of people developed depression, mood alterations, irritability, insomnia, posttraumatic stress disorder and emotional exhaustion. A number of mental health supporting strategies need to be adopted to reduce the psychological impact of COVID19 pandemic. Some of these strategies include providing psychological support in form of tele psychotherapy, keeping away from mis- information, engaging in physical activity, chanting, yoga and meditation etc. Vulnerable population such as elderly people especially those who are staying alone and those already suffering from preexisting mental disorder should have access to psychologists.
GLP-1 analogue as a novel approach for fertility treatment: unravelling the therapeutic potential: A narrative review
Authors: Lindenberg DVM PhD Frederikke , Ulsø Bsc.med PhD Ida , Almind MD PhD Gitte Juul , García Marta Peña , Sømer Emilie Færch , Lindenberg Dr. Med. Svend
Published: August 2023

Glucagon-like peptide-1 (GLP-1) analogues have emerged as promising therapeutic agents for the treatment of type 2 diabetes. Recent studies have suggested a potential role of GLP-1 in reproductive functions, offering new avenues for fertility treatment. This paper aims to review the current understanding of GLP-1 analogues to human reproduction, focusing on their potential application in fertility treatment, and discussing the molecular mechanisms and signalling pathways involved. Further, we highlight the challenges and future directions in the application of GLP-1 analogues for fertility treatment.
A brief overview of solar cycle variability effects on climate
Authors: Davy Manyika Kabuswa , Alfred Daka , Matindih Levy Kahyata , Agripa Hamweendo , Mukonda Danny
Published: August 2023

Among interesting areas of scientific research is the study of the relationship between solar cycle variability and climate change. For centuries now, speculations on the influence of variations in the sunlight intensity on climate have been on going. It is without exaggeration to state that generally the earth has gotten warmer over the past centuries. Over the years, studies have shown that there is a very strong correlation between earth’s surface temperature and sunlight intensity variability. Some scholars argue that the main effect on the weather is not a change in the luminosity of the Sun during the period of maximum activity, but an increase in the flow of charged particles (solar wind). These act on the Earth’s magnetosphere and ionosphere. This action plays a role of the trigger that starts the processes, the energy of which is contained in the Earth’s atmosphere. The periodicity of these processes (hurricanes, floods, epidemics) often correlates with the period of solar activity. Nevertheless, it is quite possible that there may be the processes with a much longer period (hundreds and thousands of years). Some researchers suggest, that the observed increase in the Earth’s temperature is part of this long-term process. Thus, this piece of work compares these two views in an attempt to check the effects of solar cycle variability on climate.
Preparation of inclusion complex between ellagic acid and hydroxypropyl-β-cyclodextrin
Authors: Thi Lan Pham , Van Cuong Bui , My Hanh Le Thi , Phuong Lan Nguyen Thi , Roman Kushnir , Tatyana Usacheva
Published: August 2023

In recent years, the research and discovery of antioxidants of natural origin, such as those found plants, have increased dramatically. Ellagic acid is a bioactive compound found in many fruits and vegetables, which carries many biological activities, such as antioxidant, anti-inflammatory, anti-cancer and antibacterial activities. However, the low solubility of ellagic acid in water decreases its practical application. In this study, a complex of ellagic acid with hydroxypropyl-cyclodextrin was synthesized in the water-ethanol solvent. The results showed that the solvent with a volume content of EtOH of 20% was the most suitable for complex formation, with complexation yield of 46%. The complex was characterized by FTIR, DSC methods. The infrared spectrum of the complex is similar to that of HP-β-CD, however, the intensity and position of some oscillations in the complex have changed significantly, compared to spectra of EA and HP-β-CD. The sharp adsorbance band at 3475 cm-1 of the O-H bond of EA was not observed in the spectrum of the complex, indicating that the O-H group participated in the bonding and covered by the hollow cavity of the HP-β-CD molecules. The DSC curve of the complex shows that the melting points of EA and HPβCD in the complex are declined in terms of temperature and intensity. This is evidence that there is a complex interaction between EA and HPβCD. The complexation improved the solubility and antioxidant activity of EA. Especifically, the solubility of EA was increased by 3.2 times compared to raw EA; EC50 value of EA was reduced from 5.3x10-5 to 4.9x10-5mol. L-1 after complexation.
Remarkable Event in the History of Russian Children Healthcare (to the 260th Anniversary of the Imperial Moscow Orphanage Foundation)
Authors: Baranov Alexander A. , Albitskiy Valery Yu.
Published: August 2023

1 сентября (12 сентября по новому стилю) 1763 года навсегда вошло как красная дата в историю развития российской системы охраны здоровья матери и ребенка, отечественной педиатрической науки и практики. В этот день 260 лет назад императрица Екатерина Вторая подписала Манифест об учреждении в Москве «Сиропитального дома» с госпиталем для бедных родильниц, названного Императорским Московским воспитательным домом (ИМВД).
Yoghurts in Infants’ Nutrition: Opportunities of Infectious and Non-Communicable Diseases’ Prevention
Authors: Belyaeva Irina A. , Bombardirova Elena P. , Turti Tatyana V.
Published: August 2023

This review provides data on the use of yogurts in infants’ nutrition. The properties of these fermented milk products and associated urgent and delayed sanogenetic effects are described. The experience of yogurts (enriched with pre- and probiotics) implementation in the nutrition therapy of children who have undergone infectious diseases is shown. The yogurt usage for intestinal microbiota disorders correction in children with functional digestive disorders and chronic somatic pathology is discussed.
Resolution of the ХХIV Congress of Pediatricians of Russia with International Participation “Actual Problems of Pediatrics”
Authors: Editorial Article
Published: August 2023

XXIV Конгресс педиатров России, в котором приняли участие около 10 тыс. участников (из них свыше 3 тыс. очных делегатов) из различных регионов Российской Федерации, среди которых — педиатры, детские специалисты, организаторы детского здравоохранения, а также ученые, преподаватели высшей школы, студенты, ординаторы и аспиранты, обсудил актуальные проблемы охраны здоровья детей и принял следующую резолюцию.
Resolution of the II All-Russian Vaccine Assembly “Protecting Generations”
Authors: Editorial Article
Published: August 2023

В период с 3 по 5 марта 2023 г. в Москве проводилась II Всероссийская вакцинальная Ассамблея «Защищая поколения», в рамках которой состоялось 14 научных симпозиумов, пленарных заседаний, круглых столов и экспертных советов, посвященных наиболее актуальным вопросам отечественной и глобальной иммунопрофилактики инфекционных болезней.
EN PRENSA. Compuestos fitoquímicos en almidones de frutos de guanábana (Annona muricata L.). EN PRENSA
Authors: De los Santos-Santos M.A. , Balois Rosendo , Bello-Lara J.E. , León- Fernández A.E. , Jiménez-Zurita J.O. , Bautista-Rosales P.U. , Ramírez-Balboa G. , Casas-Junco P. P. , Montalvo-González E.
Published: August 2023

Las investigaciones en almidones que contengan compuestos fitoquímicos son nuevas oportunidades en la producción de alimentos funcionales y suplementos dietéticos. Los almidones que contienen estos compuestos pueden tener efectos benéficos para la salud, como propiedades antioxidantes. Los almidones se encuentran en una variedad de fuentes no convencionales, dentro de los cuales se encuentran los frutos de guanábana. El objetivo de este estudio fue determinar el contenido de compuestos fitoquímicos en almidones extraídos de frutos de guanábana mediante método convencional y ultrasonido. Se extrajo almidón de frutos de guanábana mediante método convencional y ultrasonido obteniéndose dos fases por cada método; se determinó el contenido de amilosa y lípidos, así como el contenido de compuestos fitoquímicos en los almidones (fenoles, taninos, flavonoides, fitoesteroles, alcaloides y acetogeninas). Las extracciones fueron: ACF1 (Almidón convencional fase 1), AUF1 (almidón convencional fase 1), AUF2 (Almidón ultrasonido fase 2), ACF2 (almidón convencional fase 2). Los almidones de AUF1 presentaron alto contenido de fenoles solubles totales (2.26 mg EAG / g de a.b.s.), taninos (0.99 mg EAG / g de a.b.s.) flavonoides (1.55 mg EQ / g de a.b.s.), fitoesteroles (3.55 mg / EC g de a.b.s.), alcaloides (8.42 mg EA / g de a.b.s.) y acetogeninas (1.81 mg EAn / g de a.b.s.). El método de extracción de almidones asistido por ultrasonido incrementa el contenido de almidones de frutos de guanábana y compuestos fitoquímicos. Los compuestos fitoquímicos presentes en los almidones de frutos de guanábana son fenoles, flavonoides, taninos, alcaloides, fitoesteroles y acetogeninas.
Challenges in Development and Qualification of PCR/dPCR Assays for Gene Therapy Biodistribution and Viral Shedding Assessment
Authors: Pineault Kyriel Marie , Danis Bénédicte , Lory Sabrina , Yuill Daisy
Published: August 2023

Gene therapies are part of a larger class of advanced therapies that aim to treat disease via delivery of recombinant genetic material. A gene therapy product has two components, the delivery system (viral vector or non-viral) and the transgene (DNA or RNA). These therapies act via replacement of a non-functional gene, silencing of a disease-causing gene, or introduction of a new or modified gene with the goal of generating a therapeutic response in patients. Gene therapy biodistribution and viral vector shedding must be evaluated during non-clinical testing. Polymerase chain reaction (PCR) has emerged as the technique of choice to quantify the gene therapy product and the transferred genetic material in study samples. With increasing numbers of gene therapies in pre-clinical development, there has been a concomitant increase in the use of PCR in bioanalytical laboratories. A major challenge in this space is the lack of formal guidance for the development, characterization, and validation of PCR assays. This article will focus on the opportunities and challenges in developing and characterizing non-GLP, digital PCR assays for AAV gene therapy products. AAV vectors are currently the most common viral delivery system, however many of the insights presented will be applicable to other delivery systems.
IRBESARTAN REDUCES LIVER DAMAGE INDUCED BY LIPOPOLYSACCHARIDE VIA INHIBITION OF TOTAL OXIDANT STATUS, INTERLEUKIN-1B AND CASPASE-3 LEVELS
Authors: NURLU TEMEL Esra , AĞIRCA TAŞAN Şerife , İLHAN İlter
Published: August 2023

Objective

In septic conditions, hyperinflammatory response

and hepatotoxicity are caused by oxidative stress,

inflammation, and apoptosis. Irbesartan (IB), an

adrenergic receptor blocker, has anti-inflammatory and

antioxidant properties. This study aimed to investigate

the protective effect of IB on lipopolysaccharide (LPS)-

induced acute hepatotoxicity.

Material and Method

A total of eight rats were used in three groups; a control

group; LPS group [5 mg/kg, intraperitoneally (IP)];

and LPS + IB group [5 mg/kg LPS (IP) + 50 mg/kg IB

(orally)]. After sacrification, tissues from the liver and

blood were obtained for immunohistochemical and

biochemical evaluations, such as interleukin-1 beta

(IL-1β), caspase-3 (Cas-3) alanine aminotransferase

(ALT), aspartate aminotransferase (AST), oxidative

stress index (OSI), total oxidant status (TOS), and

total antioxidant status (TAS).

Results

Compared with the control group, increased AST

and ALT levels in the blood, biochemically increased

TOS and OSI and decreased TAS levels in the

tissue, immunohistochemically increased IL-1β, Cas-

3, detected. Also, in liver tissue, histopathologically

hyperemia, hemorrhage, vacuolization, and

significant neutrophilia infiltration were found in the

LPS group. IB administration significantly reversed

all these parameters. TAS levels were increased

by IB administration, whereas TOS and OSI levels

were decreased (p = 0.001). IB also decreased

AST and ALT values (p = 0.001). In the IB group,

Cas-3 and IL-1β levels were significantly decreased

by IB administration (p = 0.001). In addition, the

IB ameliorated histopathological findings showed

enhanced hyperaemia, haemorrhages, vacuolisation

and significant neutrophilic leukocyte infiltration

(p = 0.001). IB treatment attenuated LPS-induced

hepatotoxicity by its antioxidant, anti-inflammatory and

antiapoptotic properties.

Conclusion

Attenuating liver injury and restoring liver function lowers

morbidity and mortality rates in patients with sepsis.

IB protects liver tissue from hepatotoxicity caused by

LPS thanks to its antioxidant, anti-inflammatory, and

anti-apoptotic properties. Further investigation of the

liver’s role in sepsis may lead to the development of

new therapeutic targets and strategies. IB may be

an alternative therapeutic agent for the prevention of

acute hepatotoxicity during sepsis.
CRISPR/Cas9 genome editing v1
Authors: not provided wusj
Published: August 2023

This protocol describes the generation of DNAJC5 KO using CRISPR/Cas9 edition
A study comparing the change in drug utilization pattern in medical intensive care unit of a tertiary care hospital in seven years
Authors: Karve Ashwini V. , Chaure Mayur M.
Published: August 2023

Background: Medical intensive care unit is a type of intensive care unit that takes care of a range of medical illnesses with patients who are seriously ill and/or suffer from severe chronic illnesses. These patients are usually prescribed multiple drugs. Use of antimicrobial agents and injectable medications in setting of MICU is high as compared with other class of drugs and other hospital settings respectively. Periodic evaluation of drug utilization pattern needs to be done to enable suitable modifications in prescription of drugs to increase the therapeutic benefit and decrease the adverse effects. There could be changes in drug utilization pattern due to changes in disease pattern, development of newer drugs, resistance to antimicrobial agents. Hence comparison of past and present data needs to be done to find out the changes that occurred in drug utilization pattern over the years.
Methods: Data was collected from June 2021 to Dec 2021 for prospective arm and June 2014 to December 2014 for retrospective arm was obtained from MICU of tertiary care hospital and Medical Record Department. Drug utilization pattern was analysed and compared with appropriate statistical tests.
Results: Most common cause of MICU admission was infective diseases (71% and 67% respectively in retrospective and prospective arm). The drug prescribed frequently was pantoprazole and antimicrobial was ceftriaxone in both the study arms. Half of the drugs were prescribed by generic names in both arms.
Conclusions: There was no change observed in drug utilization pattern and disease pattern in patients admitted to medical intensive care unit over the years in our institute.
Rationale use of drugs in pregnancy induced hypertension at a tertiary care hospital
Authors: S. Dwajani , Kulkarni Samhitha , Vincent Andrea S. , B. M. Sanjana
Published: August 2023

Background: Pregnancy induced hypertension known as preeclampsia is considered to be the second cause of death next to anaemia. There are significant sources of maternal and foetal mortality and morbidity. Antihypertensive medication reduces the progression of the course of hypertensive disorders. However, its effect on the outcomes of pregnancy may include development of preeclampsia, preterm delivery, foetal /neonatal demise, IUGR, low birth weight. Whether such associations are casual or confounded is unknown. Hence, we intended to study the rationale use of drugs in pregnancy induced hypertensive patients.
Methods: Patients diagnosed with hypertensive disorders in pregnancy were recruited. Pregnant women in the age group of 18-45 years who consented to participate were included. Non pregnant women and women with PCOD, depression and on any medications were excluded. Details on drug treatment, type of drugs, combination, dose, dosage and duration were noted.
Results: 105 patients were enrolled. 51% belonged to 18-25 years. 98% mothers received monotherapy and 2% received dual therapy. Labetalol was the most commonly prescribed drug. 50% of the patients received a combination of Nifedipine and Methyldopa while another 50% received Nifedipine with Labetalol. The outcome of new born babies born in mothers receiving antihypertensive drugs had complications of low birth weight and malformations. The dose of the medications prescribed was well within the range.
Conclusions: Proper counselling to the patients regarding life style management, regular follow ups and monitoring of blood pressure is important to understand, resolve the burden and complication.
Drug utilization pattern in patients of upper respiratory tract infections in pediatrics outpatient department at a tertiary care hospital
Authors: Hotwani Jitendra H. , Tathe Ankita V. , Save Sushma
Published: August 2023

Background: Upper respiratory tract infections are the most common and frequently occurring infections in the pediatric population. These infections include conditions like common cold, laryngitis, pharyngitis, tonsillitis, acute rhinitis, acute rhinosinusitis and acute otitis media. Young children have an average of 6-8 colds per year, however 10 -15% of children have at least 12 infections per year. This study concentrates on prescription pattern of Upper Respiratory Tract Infections in children. primary objective was to study the prescription pattern of drugs used in URTI in pediatric outpatient department and the secondary objective was to determine whether the drugs being prescribed comply with those listed in the National list of essential medicines.
Methods: This study was a Cross-sectional, observational study conducted at the Pediatric Outpatient Department in a tertiary care hospital, India. The data was collected from patients visiting Pediatrics OPD from June 2021 to December 2021 after taking written informed consent. Sample size was calculated to be 303.
Results: Total 943 drugs were prescribed for 303 patients with an average of 3.11±1.15 drugs per prescription. Most common class of drugs prescribed was Antipyretics of which Paracetamol was the most common drug. Antibiotics were prescribed for 19.80% patients & combination of Amoxicillin and Clavulanic acid was the most common antibiotic prescribed. 68.29% drugs were prescribed by generic name. 43.16% drugs were prescribed from National List of Essential Medicines 2015.
Conclusions: The study revealed that the majority of children suffering from URTI were below 5 years of age. Our study highlighted the prescribing.
Perception, knowledge and attitudinal assessment of drug promotional literature among second year, medical undergraduate students: a questionnaire-based study
Authors: Deikar Sweety Ramesh , Samuel Lois James
Published: August 2023

Background: WHO defines drug promotion literature (DPL) as “all informational and persuasive activities by manufacturers, the effect of which is to induce the prescription, supply, purchase and/or use of medicinal drugs”. Benefit driven marketing of new drugs by drug companies may lead to erroneous prescription due to insufficient understanding, knowledge of safety and therapeutic benefits of the drugs in the community. All these promotional activities influence the prescribing pattern of doctors. 2nd year of undergraduate medical course is the appropriate time to educate the medical undergraduate students about fundamentals of DPL and to train them accordingly for improving their prescribing behaviour eventually.
Methods: A prospective questionnaire-based study was conducted in Goa Medical College. The study participants consisted of 150 II-year undergraduate medical students. Approval from Institutional Ethics Committee was obtained. The feedback forms were collected from the students after they were completed and data was analysed and represented as counts and percentages.
Results: Among respondents 36% of students opined that the quality of details provided by medical representatives is biased and too commercial followed by others. 40.7% of students were of the view that the most important intervention needed to reduce the impact of drug promotion on prescribing was to formulate policies and guidelines for the health care authorities.
Conclusions: Promotional activities by manufacturers influence the attitude and prescribing pattern of doctors. So, it is of utmost importance to train medical graduates in order to enable them to develop the skill of critical analysis of DPL and consequently rational prescribing.
Study on clinical profile of ventilated children in a pediatric intensive care unit of tertiary care centre
Authors: S. N. Pushpa , Savaskar S. V. , Ansari Atif , Parmar Manish
Published: August 2023

Background: Mechanical ventilation constitutes a major therapeutic modality in intensive care, so care of patients requiring ventilatory support is an integral part of the critical care unit. Very less data is available from developing countries regarding use of Mechanical Ventilation, its complication and outcomes which is a challenge for modern day intensivists. Objectives were to study clinical profile of ventilated children in a PICU of tertiary care centre.
Methods: Present prospective cross-sectional study was conducted on ventilated children admitted at PICU of Dr. VMGMC hospital, Solapur. The study included demographics, clinical profile, indication for ventilation, length of hospital stays, outcome.
Results: Out of 300 children, 170 were males. Most the children were from age group <5 years. Difficulty in breathing was seen in 188 cases, fever in 55%, 100 patients had acute CNS infections, 82 cases had bronchopneumonia, 85 cases respiratory failure was the indication for intubation. The duration of the mechanical ventilation was more in CNS cases, RS cases, sepsis cases. 165 cases got recovered successfully.
Conclusions: Mechanical ventilation is one of the major supportive modalities used in critical care all over the world and is also used in many of the sick children in government tertiary care centre. Despite of its life saving advantages, mechanical ventilation is associated with complication. Early use of HHFNC, CPAP/BiPAP and other non-invasive modes of ventilation decrease the need for invasive mechanical ventilation.
Study on clinical presentation of malaria and response to antimalarial treatment in children less than twelve years
Authors: Goswami Priyanka , Pathak Gargi H. , Chauhan Anuya V.
Published: August 2023

Background: In the tropical country of India, malaria in pediatric age group is one of the most important cause of mortality and morbidity. The study aimed to identify the clinicoepidemiologic features and response to antimalarial treatment in the children.
Methods: Prospective analytical study conducted for the same over the period of two years in tertiary care hospital (September 2019 to September 2021). All children under twelve years hospitalised with fever and were diagnosed to have malaria by Peripheral smear or RDT were included in the study after ethical clearance and parental consent. Total sample size was 90.
Results: Incidence of the malarial disease among total admitted patients in our study period was found to be 3.5%. The highest percentage of patients with malaria belonged to age group of 13m to 5 years (40%) and least being the age group 10-12years (7.7%). In study fever was found to be the major chief complaint followed by chills and rigor. Bleeding diathesis was least common It was found out from our study that overall most common clinical finding in the study patients was anemia or pallor with an overall of 35 patients (38.8%). Almost 73.3% (66) patients had anemia out of which 14.4% (13 patients) overall where found to have severe anemia and 27.7% (25) had moderate anemia and 31.1% (28 patients) had mild anemia. 27.7% (25) cases satisfied one or more WHO criteria for severe malaria.
Conclusions: The emergence of severe malaria caused by P. vivax could have significant implications in planning the malaria-control programmes for the community. The widespread use of ACT for severe malaria as per the guidelines of the WHO could result in the emergence of resistant parasite strains. It may be rational to continue the use of chloroquine for malaria due to P. vivax in chloroquine-sensitive areas. In places where both P. vivax and P. falciparum co-exist, measures need to be equally targeted to P. vivax to decrease morbidity and mortality due to severe malaria.
A study of clinical profile and outcome of pneumonia associated with traditional child rearing practices in infants
Authors: Kulkarni Nagamani , Ukkali Sadashiva B. , Gangawati Sujay P. , Shetty Prasanna K. , Thobbi A. N.
Published: August 2023

Background: Customs and traditions are strictly followed in many Indian families, both rural and urban. Certain established child rearing practices are being advocated by elders and are being followed traditionally even today. Many of these practices play a significant role in causing pneumonia in children. This study was undertaken to compare and assess the clinical features and outcome of pneumonia occurring in children with traditional rearing practices and in infants without traditional child rearing practices and various factors influencing them.
Methods: The present study is a prospective case control study, done in the department of paediatrics, Al-Ameen Medical College and Hospital Vijayapura, in which a total of 220 infants with clinical and/or radiological signs of pneumonia were enrolled during the period of March 2022 to February 2023.
Results: 73 out of 220 infants (33%) with pneumonia had history of traditional child rearing practices. Demographic factors like combined families, young and illiterate mothers, lower socioeconomic status, domiciliary deliveries were found to be statistically significant. Increased clinical severity and prolonged outcome (60.4%) and complications (42.5%) were found to be more in pneumonia in infants associated with traditional child rearing practices.
Conclusions: This study showed increased clinical severity and prolonged outcome and more complications of pneumonia in infants associated with traditional child rearing practices. High mortality (7.5%) was also seen. Most common traditional child rearing practices influencing outcome in infants are oil bath and blowing into the nose. Thus there is an urgent need to systematically study the utility, futility and possible dangers of a large number of traditional child rearing practices followed in infants.
Pyloric stenosis in a Bangladeshi child due to corrosive ingestion
Authors: Dey Rajib K. , Shaker Moulud H. , Deb Kanchan K. , Benzamin M.
Published: August 2023

Accidental corrosive ingestion in children is one of the common problems of childhood trauma worldwide. Gastric outlet obstruction is rare, but it is a well-known complication of corrosive acid ingestion. It mostly occurs at the pylorus and antrum due to the pooling of the corrosive agent. This report presents an experience with a 7-year-old Bangladeshi boy with gastric outlet obstruction after an accidental corrosive ingestion.
Wildervanck syndrome: case report from a tertiary care centre
Authors: Paul Ebin Roshan , Chacko Anjali Ann , P. Varsha V. , P. Sobha
Published: August 2023

One suspected case of Wildervanck syndrome (OMIM 314600) reported from our tertiary care centre. Wildervanck syndrome is distinct from other similar conditions due to its opthal and hearing associations-forming a clinical triad. Candidate gene identification in Wildervanck syndrome is still pending whereas most other similar genetic conditions has got a specific gene mutation. Klippel Feil anomaly suspected one girl admitted in our centre with severe pneumonia showed features of short neck, fusion of cervical spines and Sprengel deformity. Detailed examination showed bilateral severe sensorineural hearing loss, Duane eye movement with other novel associations not described in literature. We clinically suspected Wildervanck syndrome and did molecular testing. Being clinicians, it is our responsibility to report new associations and clinical findings and thus broaden the phenotype. Since it is a highly infrequent disorder, discussed in detail here.
Inflammed appendix as a cause of incarcerated inguinal hernia in a neonate
Authors: Kadian Y. S. , Asati Shiva , Ali M. M.
Published: August 2023

Inflamed appendix as a cause of incarcerated inguinal hernia is a rare presentation in any age group. Appendix as a content in an inguinal hernial sac was named after the French surgeon Claudius Amyand (c.1681-1740), who performed the first successful appendectomy, on an 11-year-old boy who presented with an inflamed, perforated appendix in his inguinal hernia sac. Treatment of this condition is herniotomy with its repair with or without appendectomy depending on its involvement (inflammation status). We are reporting the case, in which, the inflamed appendix was presented as incarcerated inguinal hernia. The management of Amyand’s hernia depends on the variability of involvement of the appendix however, in children and neonates, it is better to perform appendectomy during the hernia repair.
Unusual case of cold agglutination induced hemolysis in a child with systemic lupus erythematosus
Authors: Chithrabhanu Anoop , Subramanian Arul Rajamurugan Ponniah , Ramamoorthy Ramesh , Varadhan Mythili Seetharaman
Published: August 2023

Autoimmune hemolytic anemia (AIHA) is a common symptom of systemic lupus erythematosus (SLE), but cold agglutinin disease is uncommon. We describe a rare instance of cold agglutinin causing hemolytic anemia in an eight-year-old girl who had a history of maternal antiphospholipid antibody syndrome. The girl had hemolytic anemia, and the Coombs test revealed both warm and cold antibodies with a significant titer of cold agglutinin. Whole exon sequencing revealed a heterozygous mutation in the GPI gene, which was previously described for non-spherocytic hemolytic anemia, but its significance in SLE is unknown. Patient responded to corticosteroids and azathioprine. The purpose of this article is to highlight this extremely rare SLE manifestation and compare it to previously reported cases.
Adenomatoid odontogenic tumor: True neoplasm vs hamartoma
Authors: Rawat Garima , Aiyer Hema Malini , Bhushan Bharat
Published: August 2023

Adenomatoid odontogenic tumor (AOT) is an uncommon benign epithelial odontogenic tumor frequently involving the maxillary anterior region. It presents as an encapsulated slow growing lesion displacing the roots of associated teeth. The histopathological findings are characteristic and aid in diagnosis of this entity.

We present a case of a 28 year old female who developed an expansile swelling in the anterior maxillary region which was reported as an Adenomatoid Odontogenic Tumor (AOT) post-surgical excision.

This article discusses the hamartomatous vs true neoplastic nature of AOT along with histopathological findings.
Análise de circuitos elétricos não-lineares: o caso do conversor CA/CC de 12 pulsos
Authors: Trindade Junior Walmeran José
Published: August 2023

Neste trabalho é mostrada a análise do conversor CA/CC de 12 pulsos através da técnica das fontes fictícias de tensão para a análise de circuitos elétricos não-lineares descrita em [1], [2], [3] e [4] [...].
Aplicações da informática em saúde
Authors: Santos Josemary Marcionila Freire dos , Brasil Lourdes Mattos
Published: August 2023

Informática em saúde é um dos campos mais emergentes nos dias atuais devido à necessidade de se aplicar tecnologia em saúde com a finalidade de monitorar o paciente [...].
Sistema especialista simbólico para auxílio aos usuários de computadores
Authors: Cabrera Jean Carlos , Brasil Lourdes Mattos , Kimura Gilson Da Cruz
Published: August 2023

O trabalho desenvolvido objetivou principalmente a ilustração da funcionalidade de um sistema especialista baseado no paradigma simbólico [...].
Aspectos ético-legais da telemedicina
Authors: Costa Karoline Lira Dantas da , Brasil Lourdes Mattos , Santos Nilton Freire
Published: August 2023

A telemedicina consiste no uso das tecnologias de telecomunicações e informática com a finalidade de realizar atos profissionais médicos, estando o médico e o paciente geograficamente distantes [...].
Aplicações em realidade virtual
Authors: Araújo Isabella Monte Leite de , Brasil Lourdes Mattos
Published: August 2023

Este trabalho apresenta a teoria básica sobre a Realidade Virtual, incluindo sua história, conceituações, características, hardware, software e aplicações [...].
Informatização de um centro de vacinação
Authors: Egypto Cândido José Ramos do , Amorim Bruno Pereira de , Brito Filho Mário Toscano de , Medeiros Filho João
Published: August 2023

A integração da informática com a área de saúde tem se desenvolvido de forma rápida e abrangente. Atualmente, observamos o surgimento de inúmeros sistemas de informação em saúde [...].
Importância da afiação de ferramentas de corte no processo de usinagem mecânica de tornearia
Authors: Silva Josevaldo Barbosa da
Published: August 2023

Este trabalho mostra a importância da qualidade da afiação das ferramentas de corte no processo de tornearia, no intuito de conscientizar os profissionais que trabalham com usinagem mecânica sobre a influência da variável ferramenta de corte na qualidade superficial e dimensional, bem como na produtividade e no custo final das peças usinadas.
Estudo da microdureza e das propriedades mecânicas de alumina sinterizada
Authors: Wolff Diva Maria Bessa , Borges Filipe Martel de Magalhães , Acchar Wilson , Maciel Theóphilo Moura
Published: August 2023

O presente trabalho tem como objetivo investigar a microestrutura e a microdureza de uma alumina sinterizada a 1650o durante 2 horas.
Síntese, caracterização e determinação da estrutura cristalina de aduto de índio metileno com ligante do grupo 15
Authors: Peppe Clovis , Oliveira Carlos Alberto Fernandes de
Published: August 2023

A reação de InX com CH2X2 em 1,4-dioxano ou acetonitrila forma o correspondente X2InCH2X solvatado, o qual reage com E(C6H5)3 (E= P, As, Sb) para formar X3InCH2E(C6H5)3 [...].
Estudo da variabilidade espacial da condutividade elétrica da água do lençol freático, em São Gonçalo-PB
Authors: Freitas Maria Sallydelândia Sobral de , Lima Vera Lucia Antunes de , Gopinath Tumkur Rajarao , Dantas Neto José
Published: August 2023

O objetivo deste trabalho foi avaliar a variabilidade espacial da condutividade elétrica da água do lençol freático no perímetro irrigado de São Gonçalo, Estado da Paraíba [...].
A irrigação no dilema meio ambiente e desenvolvimento
Authors: Goldfarb Maurício Costa , Oliveira Raquel Costa Goldfarb de
Published: August 2023

Este trabalho, inserido no dilema meio ambiente e desenvolvimento, procura discutir a questão de salinização do solo e do alto consumo hídrico provocado pela agricultura irrigada [...].
Efeitos da condutividade elétrica e da percentagem de sódio trocável do solo no cultivo de feijão caupi (Vigna unguiculata (L) Walp) irrigado
Authors: Leite Eugênio Pacelli Fernandes , Fernandes Pedro Dantas , Gheyi Hans Raj , Silva Francisco De Assis
Published: August 2023

Problemas de salinidade e sodicidade em regiões de clima semiárido são constantes principalmente quando práticas de irrigação e de drenagem não são bem conduzidas [...].
Gestão da etapa de projetos
Authors: Oliveira Jeferson Mack Souza de
Published: August 2023

A etapa de concepção dos projetos é de fundamental importância no desenvolvimento de todo o processo de execução de obras de edificação, bem como na sua posterior ocupação [...].
Uma análise comparativa da redução de perdas na alvenaria de vedação
Authors: Meira Gibson Rocha , Araújo Nelma Mirian Chagas de
Published: August 2023

O ambiente da construção tem se tornado cada vez mais competitivo. Atualmente somente empresas eficientes que racionalizam seus processos terão mais chances para permanecer nesse ambiente [...].