bluuebunny/crossref_metadata_2025 huggingface dataset:
Part-time Work and Sickness Absence – an Organization-level Analysis
Authors: Jacobsen Dag Ingvar , Fjelde Viktoria
Published: January 2023

Background
Absenteeism is consistently higher in public than in private organizations, and represents great cost for both individuals, organizations, and society. Most research on absenteeism has focused mostly on the individual level, less on whether and eventually how one of all organizations’ basic organization of work – the number of hours worked – affects absence. This study focuses on the relationship between part-time work and sickness absence at the organizational level.
Methods
The data is a six-year panel for all Norwegian municipalities, linking register data on both part-time employment and sickness absence, while controlling for other relevant organizational and environmental variables like municipal size and economic resources. Data were analyzed using OLS regression with fixed effects for municipality and time.
Results
The main findings are that the organizations’ use of part-time work is unrelated to sickness absence.
Conclusions
While concerns have been raised on whether part-employees would be less attached to the organization, leading to higher absenteeism, this study indicates that organizations with extensive use of part-time work do not experience higher levels of absenteeism than those having less extensive use of part-time employees.
Analyzing the diagnostic value of ultrasound on different-sized thyroid nodules based on ACR TI-RADS
Authors: li weimin , Ye Feng , Yang Chen , Xu Dong , Fan Xiaofang
Published: January 2023

Purpose: The current study aims to explore diagnostic value of the thyroid imaging, reporting and data system (TI-RADS) published by the American College of Radiology (ACR) on different-sized thyroid nodules.
Methods: A total of 1183 thyroid nodules were selected from 952 patients with thyroid nodules confirmed by surgical pathology from January 2021 to October 2022. Based on the maximum diameters of the nodules, they were stratified into groups A (≤ 10 mm), B (> 10 mm, < 20 mm) and C (≥ 20 mm). The ultrasonic features of the thyroid nodules in each group were evaluated and scored based on ACR TI-RADS, and the receiver operating characteristic curve (ROC) was plotted to determine the optimal cut-off value for the ACR TI-RADS scores and categories in each group. Finally, the diagnostic efficacy of ACR TI-RADS on different-sized thyroid nodules was analyzed.
Results: Among the 1183 thyroid nodules, 340 were benign, 10 were low-risk and 833 were malignant. The scores and categorical levels of malignant thyroid nodules in each group were higher than those of benign ones (P<0.05). The areas under the ROCs (AUCs) plotted based on scores were 0.741, 0.907, and 0.904 respectively in the three groups, and the corresponding optimal cut-off values were > 6 points, > 5 points and > 4 points respectively. While the AUCs of the ACR TI-RADS categories were 0.668, 0.855, and 0.887 respectively in each group, with the optimal cut-off values were all > TR4. Besides, for thyroid nodules of larger sizes, ACR-TIRADS exhibited weaker sensitivity with lower positive prediction value (PPV), but the specificity and negative prediction value (NPV) were both higher, presenting with statistically significant differences (P < 0.05).
Conclusion: For thyroid nodules of different sizes, the diagnostic efficacy of ACR TI-RADS varies as well. The system shows better diagnostic efficacy on thyroid nodules of > 10 mm than on those ≤ 10 mm. Considering the favorable prognosis of thyroid microcarcinoma and the low diagnostic efficacy of ACR TI-RADS on it, the scoring and classification of thyroid micro-nodules can be left out in appropriate cases, so as to avoid the over-diagnosis and over-treatment of thyroid microcarcinoma to a certain extent.
Manufacture of carbon storage sintered body using microwave-selective and high-speed heating techniques
Authors: Kashimura Keiichiro , Oshita Akio , Miyata Takeshi , Segawa Satoru , Yokawa Hiroshi , Tendo Kazunari , Kurooka Kouhei
Published: January 2023

Microwave sintering of fly ash samples with large amounts of unburned carbon and CaCO3 was examined in this study. To this end, CaCO3 was mixed with fly ash sintered body to fix CO2. The decomposition of CaCO3 was observed when the raw material was heated to 1000 ℃ using microwave irradiation; however, a sintered body containing aragonite was obtained when the raw material with water was heated to 1000°C. Further, carbides in the fly ash could be selectively heated by controlling the microwave irradiation. The microwave magnetic field created a temperature gradient of 100°C in a narrow region of 2.7 µm or less in the sintered body, and it helped suppress the CaCO3 decomposition of the mixture in sintering. By storing water in the gas phase, CaCO3, which is difficult to sinter with conventional heating, can be sintered without decomposing.
Dark-Bright Exciton Splitting Dominates Low-Temperature Diffusion in Halide Perovskite Nanocrystal Assemblies
Authors: Bornschlegl Andreas , Lichtenegger Michael , Luber Leo , Lampe Carola , Bodnarchuk Maryna , Kovalenko Maksym , Urban Alexander
Published: January 2023

Semiconductor nanocrystals could replace conventional bulk materials completely in displays and light-emitting diodes. However, the organic ligands enabling their unique optical properties, prevent current flow in nanocrystal films, leaving energy transfer as the only means of injecting or extracting carriers. Here, we investigate exciton diffusion in halide perovskite superlattices - nearly perfect 3D nanocrystal assemblies. This high degree of order is not as crucial as the individual nanocrystal size, which affects transport differently depending on temperature. Up to 70 K, a confinement-induced splitting of excitonic energies, especially for the smallest nanocrystals, traps excitons into dark levels, suppressing diffusion. At intermediate temperatures, the distance of individual FRET steps corresponding to nanocrystal size enhances diffusion in the larger nanocrystals. This trend is reversed, as exciton dissociation and carrier trapping in less strongly confined nanocrystals become dominant up to room temperature. Our results reveal that transport must be factored strongly into nanocrystal design strategies for future optoelectronic applications.
Improving the efficiency of household insecticide testing against mosquitoes
Authors: Martins Walter Fabricio Silva , Reid Emma , Tomlinson Sean Sean , Evans George , Gibson Jennie , Guy Amy , Donnelly Martin , Weetman David
Published: January 2023

Background
Developing robust, standardized approaches for testing mosquito populations against insecticides is a vital step for understanding the effectiveness of new active ingredients or formulations. Methods for testing mosquito susceptibility against contact insecticides or products, such as those delivered through public health programmes are well-established and standardized. Nevertheless, approaches for testing volatile or aerosolized insecticides used in household products can be challenging to standardize and implement efficiently.
Methods
We adapted WHO guidelines for household insecticides to develop a standardized and higher-throughput methodology for testing aerosolized products in Peet Grady test chamber (PG-chamber) using caged mosquitoes and an efficient decontamination method. The new approach was validated using insecticide resistant and susceptible Aedes and Anopheles mosquito colonies. An added feature is the inclusion of cage-facing cameras to allow real-time quantification of knockdown following insecticide exposure.
Results
The wipe-based decontamination method was highly effective for removing pyrethroids’ aerosolized oil-based residues from chamber surfaces, with < 2% of recorded mortality for susceptible mosquitoes tested directly on the surfaces. There was no spatial heterogeneity for knockdown or mortality of caged mosquitoes within the PG chamber, and the dual-cage approach applied effectively discriminate susceptible and resistant mosquito colonies tested side-by-side.
Conclusions
The dual-cage based assay that we implement yields eight-times the throughput compared to a free-flight protocol and allows simultaneous testing of different mosquito strains.
The Impact of Journal Clubs on Postgraduate Medical Education in China
Authors: Zhang Yue , Li Yujuan , Liu Rong , Hao Yi , Xiong Jing
Published: January 2023

Purpose
Journal club plays an essential role in medical education. Studies have revealed its contribution in many countries except China. Chinese medical postgraduates are divided into academic and clinical types. This study aims to investigate their participation, performance, and gains in journal clubs and how student type and study phase influence these aspects.
Method
The authors distributed a survey involving demographic information, participation, performance, and improvements to postgraduates at Tongji Medical College of Huazhong University of Science and Technology, and 232 questionaries were included in further analysis. Mann-Whitney U and Gamma tests were adopted for respective data, and a p-value < 0.05 was considered statistically significant.
Results
The total participation and performance resemble worldwide studies. As for student type, academic postgraduates displayed superior participation and research assistance than clinical postgraduates, while their performances were at the same level. After introducing the study phase, academic-related downward trend and clinical-related upward trend in attendance rate and listening attitude along the senior phase, as well as time-promoting presentation comments, progress after presentation and research assistance were observed.
Conclusions
In this study, the authors revealed academic postgraduates’ fatigue, clinical postgraduates’ enthusiasm, and academic-superior research assistance. We recommend encouraging and supporting scientific research training for clinical postgraduates, helping academic postgraduates establish better time management and less irrelevant work, and promoting critical appraisal skill education.
Decision support system for effective action recognition of track and field sports using Ant Colony Optimization
Authors: He Liqin , Ren Yuedong , Cheng Xinnian
Published: January 2023

Based on emerging technologies like artificial intelligence, machine learning, the Internet of Things, and virtual reality, various Decision Support Systems (DSS) are being employed for the revolution in the sports industry. The coach can now make very precise and unbiased decisions related to the players’ skills and selection. It is now very convenient to improve the skills and performance of the players through the implementation of various computer-grounded methodologies. Professionals can recognize the unwanted behavior of players in time during sports and hence can ensure a peaceful atmosphere during sports. The recognition of non-standard actions by the players can help in the avoidance of serious injuries or illness. The DSS can predict the nature of the weather and the sports personnel can take decisions regarding the carrying out of games. The players can do their training without any restrictions on space and time. The real-time analysis of already existing videos of games can help the newcomers learn and improve their skills and performance. The trainers can check the physical fitness of the sportsmen very efficiently and provide them with useful and valuable recommendations related to their fitness level. The proposed study has used the Ant Colony Optimization to recognize and track the optimal features of athletes to enhance individual as well as team performance in sport competitions.
Elucidating Morpho-Molecular Diversity and Population Structure of Elite Tomato (Solanum lycopersicum L.) Germplasm
Authors: Khan Tamana , Shah Labiba , Rashid Rizwan , Afroza Baseerat , Khan Sabba , Mansoor Sheikh , Masoodi Khalid Z. , Bhat M. Ashraf , Shah Mehraj Ul Din D. , Padder Bilal A. , Mahajan Reetika
Published: January 2023

Background
Tomato (Solanum lycopersicum L.) crop is well known for its versatility worldwide and recognized as model species used extensively for various genetic studies. This study was carried out to evaluate some indigenous and exotic tomato genotypes for divergence studies using a combined multidisciplinary approach. Regardless of its significant contributions to nutritional and economic status globally, lack of diversity among the cultivated species has been witnessed extensively due to the intensive selection of genotypes with respect to specific traits and severe genetic bottlenecks.
Methods and Results
As a part of the countermeasure to restore the genetic diversity in tomato, the incorporation of wild varieties, landraces, and traditional varieties in the crop-breeding scheme is highly acknowledged. On these grounds, inter and intra-genetic diversity was assessed among 51 tomato genotypes morphologically, biochemically, and by using DNA-based marker SSR markers. A total of 15 discrete agro-morphological traits and 6 biochemical traits were undertaken in the current study for evaluating the analysis of variance, genetic parameters, and correlation. Morphological clustering divided the genotypes into 2 clusters and the genotype-wise distance matrix was obtained to identify the most diverse genotypes. PCA analysis was conducted to understand the directive relation of traits and the magnitude of variability contributed by them. SSR profiling with 24 primers identified 44 alleles with 1.83 as a mean number of alleles/SSR with an average PIC value of 0.31. Structure analysis revealed two sub-populations (K = 2). The AMOVA indicated that 98% of the total variation was present within the populations. This study presents a roadmap for composing future breeding strategies for integrating desirable traits in novel tomato lines that combine robustness and nutritive value.
Conclusion
The tomato genotypes were found to be a rich resource of germplasm with respect to genetic variation and needs to be preserved and utilized efficiently in breeding programs to rescue the gene pool wealth. The clustering patterns revealed the distinctiveness and relatedness of the panel under study. A substantial degree of morphological and molecular diversity was attained within and among the genotypes and populations. The efficiency of the SSR marker technique used in the current study can be considered for future breeding programs.
Influencing factors and prognostic value of left ventricular systolic dysfunction in patients with complete occlusion of the left anterior descending artery reperfused by primary percutaneous coronary intervention
Authors: Jing Yongle , Lu Chengzhi , Guo Suzhen , Chen Bingwei , Ye Xuying , He Qiang , Xia Wei , Xin Ting
Published: January 2023

Background: The aim of this study was to perform a retrospective analysis of patients with acute anterior wall ST-segment elevation myocardial infarction (AAW-STEMI) whose left anterior descending (LAD) artery was completely occluded and reperfused by primary percutaneous coronary intervention (PPCI) and to determine the influencing factors and prognostic value of left ventricular systolic dysfunction (LVSD) in the acute phase of acute myocardial infarction (AMI).
Methods: A total of 304 patients with AAW-STEMI were selected. The selected patients were divided into two groups: the preserved left ventricular ejection fraction (pLVEF) group (LVEF≥50%, n=185) and the reduced left ventricular ejection fraction (rLVEF) group (LVEF<50%, n=119). The influencing factors of LVSD and their predictive value for LVSD were analyzed. Patients were followed up (median follow-up: 47 months [interquartile range: 27 to 64 months]) by examining outpatient records and via telephone. The predictive value of LVSD for the survival of patients with AAW-STEMI was analyzed.
Results: Age, heart rate (HR) at admission, number of ST-segment elevation leads (STELs), peak creatine kinase (CK) and symptom to wire-crossing (STW) time were independent risk factors for LVSD. Peak CK had the strongest predictive value for LVSD. LVSD is an independent adverse factor for long-term prognosis in patients with AAW-STEMI discharged after PPCI.
Conclusions: Age, HR at admission, number of STELs, peak CK, and STW time may be used to identify patients with a high risk of heart failure (HF) in a timely manner and initiate early standard therapy for patients with AAW-STEMI whose LAD artery was completely occluded and reperfused by PPCI. Incident LVSD in the acute phase after AAW-STEMI was significantly associated with a trend toward increased mortality at follow-up.
Impact of Non-academic Responsibilities of Teachers on Teaching Quality
Authors: Kulal Abhinandan , N Abhishek , Kanchan Swarn G , Kulal Meghashree
Published: January 2023

Teaching quality in an education system becomes the foundation and roadmap to the development of young people and country at large. If the quality of education declines the productivity of the country also declines. Whatever the type of education institutions running in the country must emphasize on improving the quality of education they are intended to provide. Nowadays it can be noticed that many education institutions are becoming commercial and mainly focusing on getting grades, certifications, rankings and recognitions. The purpose of presence study is to examine the impact of non-academic responsibilities on quality of teaching. For this purpose study adopted descriptive research design to analyse the collected data from the teachers teaching in higher education. This study observed that non-academic responsibilities are significantly influencing on teaching quality in India. Thus, the higher education institutions and regulators should work together to bring policies, strategies and methods to balance both academic and non-academic responsibilities without compromising with the teaching quality. If this will be the reality the competencies of the students for their survival will be enhanced and in turn the overall productivity of young people will also go up for the long run.
Childhood trauma and depressive level among non-clinical Chinese college students: the roles of rumination and perceived stress
Authors: Wang Junjing , Liang Qian , Ma Yueqi , Zhang Yi
Published: January 2023

Background: Childhood trauma is one of major risk factors to depression, and the incidence of depression among college students has been increasing. Previous studies have validated the effect of childhood trauma on depressive level. But few studies based on the Diathesis-stress theory to investigate the role of perceived stress in the pathway between childhood trauma and depressive level, as well as considering the role of rumination.
Methods: We recruited 995 non-clinical Chinese college students and ask them to finish four self-report questionnaires, including Childhood Trauma Questionnaire-Short Form (CTQ-SF), Perceived Stress Scale (PSS), the 22-item Ruminative Responses Scale (RSS-22), and Beck Depression Scale-II (BDI-II). Then we conducted the multiple mediation analyses and multiple linear regression analyses.
Results: Results revealed that perceived stress played a mediation role between childhood trauma and depressive level, and rumination played a moderation role between childhood trauma and perceived stress and between childhood trauma and depressive level.
Limitations: This is a cross-sectional study and based on subjective reports of measures.
Conclusions: These findings provided multi-dimensional indications for reducing the effect of childhood trauma on depressive level in college students, which would help them to improve their mental health.
Three Gorges Dam: The changing trend of the density of Oncomelania hupensis, the intermediate host for Schistosoma japonicum, in reaches of the Yangtze River, 1990-2019
Authors: Gong Yanfeng , Tong Yixin , Jiang Honglin , Xu Ning , Yin Jiangfan , Wang Jiamin , Huang Junhui , Chen Yue , Jiang Qingwu , Zhou Xiaonong , Li Shizhu , Zhou Yi-Biao
Published: January 2023

Background:
Oncomelania hupensis (O. hupensis) snail is the sole intermediate host of Schistosoma japonicum. Environmental changes caused by Three Gorges Dam (TGD), flood and drought, affect the distribution of snail population, and better understanding the dynamics and spatial distribution of snail density is critical for schistosomiasis risk assessment and control for affected areas.
Methods:
Data of O. hupensis snail survey between 1990 and 2019 were collected from previous studies in four electronic databases (CNKI, Wanfang, Pubmed, and SCI) and from the national schistosomiasis surveillance. Meta-analysis was conducted to estimate the overall and annual snail densities and their 95% confidence intervals (CIs). Joinpoint model was used to identify the changing trend and inflection point of snail density between 1990 and 2019. Inverse distance weighted (IDW) interpolation was used to determine the spatial distribution of recent snail density.
Results:
A total of 3777 snail survey sites (872 for the upstream area and 2905 for the downstream area of the TGD) with a precise location of village or beach were identified. For the downstream area of the TGD, the snail density peaked in 1998 (1.635/0.11m2, 95% CI: 1.220–2.189) and fluctuated at a relatively high level before 2003, and declined steadily from 2003 (1.143/0.11m2, 95% CI: 0.905–1.397) to 2012 (0.127/0.11m2, 95% CI: 0.081–0.199). The snail density maintained lower than 0.150/0.11m2 between 2012 and 2019. Joinpoint model identified that the inflection point of 2003 was statistically significant and the snail density showed a significant downward trend from 2003 to 2012 with an APC of -20.56% (95% CI: -24.15 to -16.80). For the Upstream area of the TGD, the snail density peaked in 2005 (0.760/0.11m2, 95% CI: 0.479–1.207) and was generally greater than 0.300/0.11m2 before 2005. The snail density steadily declined since 2006 and was generally lower than 0.150/0.11m2 after 2011. No inflection point was identified and the snail density showed a significant downward trend from 1990 to 2019 with an APC of -6.05% (95% CI: -7.97 to -7.09). The areas with a relatively high snail density were mainly distributed in Poyang Lake, Dongting Lake, Jianghan Plain, and the Anhui branch of the Yangtze River.
Conclusion:
The density of O. hupensis snails showed a fluctuating downward trend in the Yangtze River basin between 1990 and 2019. In the downstream area, the decline of snail density was accelerated after the operation of TGD, and then fluctuated at a relatively low level. Infected areas with a higher density of snails were distributed in Dongting Lake, Poyang Lake, Jianhan Plain, and the Anhui branch of the Yangtze River.
Nonagenarians Admission and Prognosis in a Tertiary Center Intensive Coronary Care Unit – a prospective study.
Authors: Bruoha Sharon , Maller Tomer , Loutati Ranel , Perel Nimrod , Tabi Meir , Taha Louay , Yosefy Chaim , Jafari Jamal , Braver Omri , Amsalem Itszhak , Hitter Rafael , Manassra Mohamed , Levy Nir , Abu-Alkean Ismael , Hamyil Kamal , Steinmetz Yoed , Karameh Hani , Karmi Mohamed , Marmor David , Wolak Arik , Glikson Michael , Asher Elad
Published: January 2023

Background
With increasing life expectancy, the prevalence of nonagenarians with cardiovascular disease is steadily growing. However, this population is underrepresented in randomized trials and thus poorly defined, with little quality evidence to support and guide optimal management. The aim of the present study was to evaluate the clinical management, therapeutic approach, and outcomes of nonagenarians admitted to a tertiary care center intensive coronary care unit (ICCU).
Methods
We prospectively collected all patients admitted to a tertiary care center ICCU between July 2019 – July 2022 and compared nonagenarians to all other patients. The primary outcome was in-hospital mortality.
Results
A total of 3807 patients were included in the study. Of them 178 (4.7%) were nonagenarians and 93 (52%) females. Each year the prevalence of nonagenarians has increased from 4.0% in 2019, to 4.2% in 2020, 4.6% in 2021 and 5.3% in 2022. Admission causes were similar in both groups except for a lower rate of ST segment myocardial infarction (STEMI) (12.9% vs. 27.3%, p < 0.001) and a higher rate of septic shock (4.5% vs 1.2%, p < 0.001) in nonagenarians. Nonagenarians had more comorbidities, such as hypertension, renal failure, and atrial fibrillation (82% vs. 59.6%, 23% vs. 12.9%, 30.3% vs 14.4% p < 0.001, respectively). In-hospital mortality rate was 2-fold higher in the nonagenarians (5.6% vs. 2.5%, p = 0.025).
Conclusions
With increasing life expectancy, the prevalence of nonagenarians in ICCU’s is expected to increase. Although nonagenarian patients had more comorbidities and higher in-hospital mortality, they generally have good outcomes after admission to the ICCU. Hence, further studies to create evidence-based practices and to support and guide optimal management in these patients are warranted.
Spreading Points using Gradient and Tabu
Authors: Huang Xiangyang , Huang LiGuo
Published: January 2023

Large spreading (packing) problems are hard to be solved exactly. Consequently, heuristic approaches are usually used to find approximate solutions. In this paper, a hybrid heuristic method, consisting of a Neighborhood Tabu (NT) and a Perturbed Gradient (PG), is proposed for solving spreading points problems. NT applies an adaptive random technique to selecting promising candidate solutions from the neighborhood of the current local minimum and PG uses a neighborhood-based perturbed gradient algorithm to seek a better minimum, starting from the candidates. Two procedures work alternatively and cooperatively. When applied to some previously studied packings, the proposed method can improve the accuracy of the previous record solutions.
Survival and neurologic outcomes following aortic occlusion for trauma and hemorrhagic shock in a hybrid operating room
Authors: Balch Jeremy A. , Loftus Tyler J. , Efron Philip A. , Mohr Alicia M. , Upchurch Gilbert R. , Smith R. Stephen
Published: January 2023

Background: Outcomes following aortic occlusion for trauma and hemorrhagic shock are poor, leading some to question the clinical utility of aortic occlusion in this setting. This study evaluates neurologically intact survival following resuscitative endovascular balloon occlusion of the aorta (REBOA) vs. resuscitative thoracotomy at a center with a dedicated trauma hybrid operating room with angiographic capabilities.
Methods: This retrospective cohort analysis compared patients who underwent zone 1 aortic occlusion via resuscitative thoracotomy (n=13) vs. REBOA (n=13) for blunt or non-thoracic, penetrating trauma and refractory hemorrhagic shock (systolic blood pressure less than 90 mmHg despite volume resuscitation) at a level 1 trauma center with a dedicated, trauma hybrid operating room. The primary outcome was survival to hospital discharge. The secondary outcome was neurologic status at hospital discharge, assessed by Glasgow Coma Scale (GCS) scores.
Results: Overall median age was 40 years, 27% had penetrating injuries, and 23% had pre-hospital closed-chest cardiopulmonary resuscitation. In both cohorts, median Injury Severity Scores and head Abbreviated Injury Scores were 26 and 2, respectively. The resuscitative thoracotomy cohort had lower systolic blood pressure on arrival (0 [0-75] vs. 76 [65-99], p=0.009). Hemorrhage control (systolic blood pressure 100 mmHg without ongoing vasopressor or transfusion requirements) was obtained in 77% of all REBOA cases and 8% of all resuscitative thoracotomy cases (p=0.001). Survival to hospital discharge was greater in the REBOA cohort (54% vs. 8%, p=0.030), as was discharge with GCS 15 (46% vs. 0%, p=0.015).
Conclusions: Among patients undergoing aortic occlusion for blunt or non-thoracic, penetrating trauma and refractory hemorrhagic shock at a center with a dedicated, trauma hybrid operating room, nearly half of all patients managed with REBOA had neurologically intact survival. The high death rate in resuscitative thoracotomy and differences in patient cohorts limit direct comparison.
Potential of patellar height measurement methods in predicting recurrent patellar dislocation incidence: A case-control study
Authors: Yamashita Satoshi , Ishizuka Shinya , Sakai Tadahiro , Oba Hiroki , Sakaguchi Takefumi , Mizuno Takafumi , Kawashima Itaru , Tsukahara Takashi , Takahashi Shigeo , Kurokouchi Kazutoshi , Imagama Shiro
Published: January 2023

Background
Recurrent patellar dislocation (RPD) is a multifactorial disease that affects young and active people. Patellar height measurements are used clinically to screen and diagnose knee conditions. However, there are no known studies that have assessed and compared the performance of patellar height indices for predicting the incidence of RPD, which could be used to recommend surgical treatment after primary patellar dislocation. This case-control study aimed to determine if the patellar height index could be used to predict the incidence of RPD, and to identify the optimal method in terms of its diagnostic ability for RPD.
Method
Altogether, 133 patients (52 patients with RPD [Group R] and 81 sex- and age-matched controls [Group C]) were enrolled in this study. The Insall-Salvati (IS), Blackburne-Peel (BP), Caton-Deschamps (CD), and modified IS (mIS) methods were used to measure the patellar height index. The intra-observer and inter-observer reliabilities of these four methods were determined using intraclass correlation coefficients. A receiver operating characteristic curve analysis was performed to evaluate the predictive ability of each index and identify the cut-off values that indicated significantly increased risk of RPD.
Results
Patient demographics were similar between the two groups. The inter-observer and intra-observer reliabilities were good for all four methods. In patients with RPD, the mean index values for the four methods were significantly higher than those in the matched controls. The area under the curve (AUC) values for IS, BP, CD, and mIS were 0.91 (standard error [SE], 0.03; 95% confidence interval [CI], 0.84–0.96), 0.72 (SE, 0.05; 95% CI, 0.63–0.81), 0.86 (SE, 0.03; 95% CI, 0.79–0.92), and 0.96 (SE, 0.01; 95% CI, 0.94–0.99), respectively.
Conclusion
Patellar height indices had high predictive performance for the incidence of RPD. The mIS method had the highest AUC.
Crestal sinus lift combining recombinant human bone morphogenetic protein-2 with leukocyte- and platelet- rich fibrin as grafting material: A 1-year retrospective pilot trial
Authors: He Dongning , 杨 扬 , Xu Linkun , Li Yi , Gao Wen , Wang Yi , Xue Lijun , Yu Feiyan
Published: January 2023

The authors have requested that this preprint be removed from Research Square.
Complete Recovery in NORSE Observed in İntensive Care Unit: A Case Report
Authors: Arıoğlu İnal Bensu , Koltka Emine Nursen
Published: January 2023

New-onset refractory status epilepticus (NORSE) is a definition used to describe clinical conditions with no history of seizures, no identifiable structural or etiological cause, and for which a diagnostic result cannot be reached by research. Its treatment is often done with intravenous anesthetic drugs and its mortality is quite high. In this article, a 33-year-old patient whose etiology could not be determined as a result of extensive research in our intensive care unit and who recovered completely is presented.
PLGA/BGP/Nef Porous Composite Restrains Osteoclasts by Inhibiting the NF-κB Pathway, Enhances IGF-1-mediated Osteogenic Differentiation and Promotes Bone Regeneration
Authors: Wu Feng , Wu Zhenxu , Ye Zhijun , Niu Guoqing , Ma Zhiliang , Zhang Peibiao
Published: January 2023

Background
Novel bone substitutes are urgently needed in experimental research and clinical orthopaedic applications. There are many traditional Chinese medicines that have effects on bone repair. However, application of natural medicines in traditional Chinese medicine to bone tissue engineering and its mechanism were rarely reported.
Results
In this study, the drug loading and controlled release ability and osteogenic ability of bioactive glass particles (BGPs) and the osteogenic and osteoclastic ability of neferine were fused into PLGA-based bone tissue engineering materials for bone regeneration. BGPs were prepared by spray drying and calcination for loading of Nef. Particles loaded with drugs were then mixed with PLGA solution to prepare porous composites by the phase conversion method. Here we showed that Nef inhibited proliferation and enhanced ALP activity of MC-T3-E1 cells in a dose- and time‐dependent manner. And the composites containing Nef could also inhibit RANKL‐induced osteoclast formation (p < 0.05). Mechanistically, the PLGA/BGP/Nef composite downregulated the expression of NFATC1 by inhibiting the NF-κB pathway to restrain osteoclasts. In the other hands, PLGA/BGP/Nef composite was first demonstrated to effectively activate the IGF-1R/PI3K/AKT/mTOR pathway to enhance IGF-1-mediated osteogenic differentiation. The results of animal experiments show that the material can effectively promote the formation and maturation of new bone in the skull defect site.
Conclusions
The PLGA/BGP/Nef porous composite can restrain osteoclasts by inhibiting the NF-κB pathway, enhance IGF-1-mediated osteogenic differentiation and promotes bone regeneration, and has the potential for clinical application.
Innovation Strategy Design of Public Sports Service Governance Based on cloud computing
Authors: Hao Yangyang , Qiu Zhaoyi , Xu Qiner , He Qiuhong , Fang Xuemo , Wang Chuyun
Published: January 2023

Public sports services are an important part of the service system of modern government construction, and play an important role in strengthening national physique, improving people's satisfaction with public services, and improving people's welfare level. With the implementation of the national sports strategy, the quality of sports is constantly improving, and significant progress has been made in sports facilities construction, sports services mechanism, sports services projects, sports services personnel, etc. Although the public sports services has made rapid progress, due to the tilt of the national development center and the difference in regional economic level, there are problems such as unbalanced urban and rural development, insufficient social security, etc. Therefore, this paper analyzed the characteristics of public sports services, the importance of development, the status quo and the causes of the status quo to study the problems in the current public sports services. According to the problems, the governance objectives and principles of sports services are constructed, and finally the innovation strategy of sports services is combined with cloud computing. It can be seen from edge computing that the update weight and the offset vector under the public sports services innovation strategy are gradually increasing over time. The average value of the update weight under the public sports services innovation strategy was about 1.28, and the average value of the offset vector was about 1.36. On the whole, the update weight under the public sports services innovation strategy increased by 0.33 in the whole process, while the offset vector increased by 0.34 in the whole process. The service quality and implementation effect of the cloud computing public sports service innovation system are better than the original public sports service system. The service quality of the cloud computing public sports service innovation system is about 10.6% higher than the original public sports service system, and the implementation effect is about 8.1% higher than the original public sports service system. In short, both cloud computing and intelligent models can promote the development of sports services.
Role of Hypertension and Obesity as Risk Factors for IHD
Authors: Ghaffari Mohammad Mujtaba. , Ahmadi Abdul Samad
Published: January 2023

Background
Hypertension and obesity are two major modifiable risk factors for CAD, most of the time there will be more than two risk factors in an IHD. Obesity itself cause insulin resistance to initiate type − 2 DM. is the most common and significant RFs for IHD, and proper BP management is the cornerstone of both direct and indirect prevention. Overweight and obesity account for more than 80% of CHD patients. Obesity is sometimes viewed as a "minor" CHD RF, however it is a widely effective risk-factor approach. A range of "major" risk factors have been proven to be significantly influenced by weight loss, including HTN, hyperlipidemia and insulin resistance/T2DM.
Aim
To assess arterial hypertension and obesity as risk factors of IHD.
Methods
This cross sectional study which was done retrospectively by collecting data from database of "Scientific Research Institute of Cardiology and Internal Diseases" Almaty city, Kazakhstan during 2020. IHD confirmed by history,physical exam, angiography and other lab findings.
Result
The research involved a total of 649 participants. The mean age of study population was 64.2 ± 9.24 (P = 0,000).Mean of SBP and DBP were 180.73 ± 34.9; 99.48 ± 14.28 mmHg respectively. Number of female with normal BMI 50(21.6%), overweight 93(40.10%), obesity class – 1, 59(25.4%), obesity class – 2, 23(9.90%) and obesity class – 3, 7(3%), (P = 0.486). Number of male with underweight BMI 1(0.20%), normal BMI 96(23%), overweight 190(45.6%), obesity class – 1, 89(21.3%), obesity class – 2, 29(7%) and obesity class – 3, 12(2.9%). (P = 0.486). Mean of BMI in both gender was (28.72 ± 11.79).
Conclusion
The burden of CVDs and their related risk factors is significant in Almaty, posing a major public health concern. For accurate management and implementation of preventive measures in this area, effective strategies in management, education, and healthcare centers are needed.
METTL3-mediated m6A modification of lncRNA TSPAN12 promotes epithelial-mesenchymal transition and metastasis of hepatocellular carcinoma through SENP1-dependent deSUMOylation of EIF3I
Authors: Li Bei , Xiong Xianze , Xu Jianrong , Peng Dingzhong , Nie Guilin , Wen Ningyuan , Wang Yaoqun , Lu Jiong
Published: January 2023

Background Our previous study revealed that lnc-TSPAN12 was remarkably upregulated in HCC and correlated with poor survival. However, the role of lnc-TSPAN12 in regulating epithelial-mesenchymal transition (EMT) and metastasis in hepatocellular carcinoma (HCC) remains uncharacterized. Methods The biological function of lnc-TSPAN12 in HCC metastasis was investigated by loss- and gain-of-function experiments both in vitro and in vivo. RNA pull-down, RNA immunoprecipitation and fluorescence in situ hybridisation were performed to examine the interaction between lnc-TSPAN12 and Eukaryotic Translation Initiation Factor 3 subunit I (EIF3I)/Sentrin/SUMO-Specific Protease 1 (SENP1) (SUMO: small ubiquitin-like modifier). EIF3I ubiquitination and SUMOylation modifications were analyzed using co-immunoprecipitation and western blot. Results Functional assays showed that lnc-TSPAN12 positively regulated the migration, invasion and EMT of HCC cells in vitro and accelerated liver metastasis in patient-derived tumour xenograft metastasis models in vivo. Importantly, methyltransferase like 3 (METTL3) mediated N6-methyladenosine modification is responsible for the upregulation of lnc-TSPAN12, contributing to lnc-TSPAN12 stabilization. Mechanistically, lnc-TSPAN12 physically interacts with EIF3I/SENP1 and functions as a scaffold to facilitate the binding of SENP1 to EIF3I, which suppresses EIF3I SUMOylation and ubiquitin degradation, ultimately activating Wnt/β-catenin signalling to promote EMT and metastasis in HCC. Conclusions Our findings elucidate the regulatory mechanism of lnc-TSPAN12 involved in metastasis of HCC and highlight the lnc-TSPAN12-EIF3I/SENP1 axis as a promising therapeutic target for the disease.
Risk Factors, Symptomatology, and Predictors of Mortality among COVID-19 Inpatients Presenting with Delirium Symptoms in a Tertiary Hospital in the Philippines
Authors: Factor Sedric John , Ly-Uson Josefina , Aligam Katrina Joy , Gelvezon Marie Angelique
Published: January 2023

INTRODUCTION Delirium is a common but under-recognized finding among patients with COVID-19. This study aimed to describe the risk factors, symptomatology, and predictors of mortality of COVID-19 patients presenting with delirium symptoms admitted in 2021 to the Philippine General Hospital, a public tertiary hospital in the Philippines.
METHODS Medical records of adult COVID-19 patients admitted to the Philippine General Hospital in 2021 were analyzed. Descriptive statistics were used to summarize the demographic and clinical history. Univariate and multivariate logistic regression were done to determine the variables that are predictive of mortality.
RESULTS Four hundred patients with COVID-19 had delirium symptoms. Of those, 36.5% were not diagnosed with delirium, only 7% were referred to Psychiatry, and 74% expired during their admission. Patients referred to Psychiatry have lower odds of mortality compared to those not referred (aOR=0.069, p=0.014); those that received midazolam had higher odds of mortality (aOR=3.112, p=0.001). Patients on mechanical ventilation (aOR=20.172), those placed on prone positioning during mechanical ventilation (aOR=6.272), those with decreased sensorium (aOR=7.438), and those with decreased psychomotor activity (aOR=3.857) all had higher odds of mortality (p<0.001).
CONCLUSIONS Timely assessment and appropriate management are critical for COVID-19 patients with delirium symptoms, especially those at an increased risk for mortality. Clinicians dealing with COVID-19 patients presenting with delirium symptoms need to be reoriented to delirium symptomatology, initial interventions, and indications for referral to psychiatrists.
Secure Framework to Enhance Security Using Hybrid Algorithm in Cloud Computing With Ssl
Authors: F MARGRET SHARMILA , K KARUPPASAMY
Published: January 2023

In the last several years, cloud computing has grown at a very rapid pace.With a growing number of enterprises relying on cloud-based services, it's more important than ever to protect the data of many users who utilise centralised resources.The privacy, preservation, and management of a user's data are just a few of the issues that Cloud Computing has to deal with. The fundamental purpose is to understand security risks in Cloud Computing and to discover efficient security measures for reducing them, as listed below. To get a better comprehension of the security situation concerns and approaches employed in today's world of Cloud Computing the hybrid SSL based Crpto System is proposed .To propose countermeasures to the future Cloud Computing's issues may confront. Various security specialists working on Cloud Computing were surveyed and interviewed. The proposed approach employ SSL or IPSec to protect the communication route between the users, the cloud, and the cryptographic server. A piece of software was created to encrypt a user's data , this is how we plan to address the security breaches that have occurred in recent years and protect data in the cloud from emerging threats
Specific Parameters of Detection of Fungi of the Genus Aspergillus in Respiratory Organs of Pulmonary Tuberculosis Patients
Authors: Panova A. E. , Lovacheva O. V. , Gracheva A. N. , Burmistrova I. A. , Naumova T. A. , Tyulkova T. E.
Published: January 2023

The objective: to study specific parameters of detection of fungi of the genus Aspergillus in respiratory organs of pulmonary tuberculosis patients.

Subjects and Methods. In 2019-2021, the samples of sputum or bronchoalveolar lavage of 520 patients above 18 years old with confirmed pulmonary tuberculosis and HIV-negative status were tested for molds. Also, all patients had their sputum or BAL tested for acid fast mycobacteria (AFB), cultures of M. tuberculosis (MBT), and DNA of tuberculous mycobacteria.

Results. Positive culture results for fungi were obtained in 50/520 (9.62%; 95% CI 7.37-12.45, Wilson test) pulmonary tuberculosis patients. Species identification revealed fungi of the genus Aspergillus in 46/50 (92%) of them.

In 37/46 (80.43%; 95% CI 66.83-89.35) patients, a single type (one species of Aspergillus) was identified, in 9/46 (19.57%; 95% CI 10.65-33.17) two types were identified. A. fumigatus (16/37 isolates, 43.24%) and A. niger (13/37 isolates, 35.14%) prevailed among single types of cultures. A. niger + A. flavus (3/9 isolates, 33.33%) was the most frequent combination. The ratio of the effectiveness of methods for detecting fungi such as culture/direct microscopy/galactomannan antigen in serum and BAL was 100/84.78/4.35% and 67.39%, respectively. Thus, BAL is more preferable than serum for detection of galactomannan antigen in patients with tuberculosis.

Only in 8/46 (17.4%) patients, bacterial excretion was detected by culture, which is typical for the active phase of the course of tuberculosis. In the remaining 38 (82.6% 95% CI 69.28-90.91) patients, no tuberculous mycobacteria were detected by culture, which was typical of stabilization and cure of tuberculosis.
Diskriminasi Pendidikan di Indonesia
Authors: Karmila Karmila , Fauziah Nurul , Safira Elsa , Atdeni Sadikin M. Nur , Wardhana Kautsar Eka
Published: January 2023

Indonesia is a country that has various kinds of diversity inherent in diversity, ethnicity, race, culture and religion. So we need multicultural education that respects differences and does not discriminate, especially in the world of education. This study aims to find out what kind of role multicultural education plays in efforts to prevent cases of discrimination in the world of education. The hope that we want to achieve in this research is to be able to describe that multicultural education can be an effort to prevent educational discrimination in Indonesia. In this study, the authors used the library research method or library search, as well as this type of method which is a type of qualitative method. This study only uses literature without field research. Multicultural education must strive that whoever and whatever the conditions of a person are all entitled to the same education because Indonesia is a country that has a lot of diversity.
A incorporação do ODS 16 pelo Judiciário Brasileiro
Authors: Vitória Paulo Renato , Ribeiro Mangueira Marques Iracy
Published: January 2023

Este artigo analisa, a partir de uma perspectiva crítica da colonialidade, as possibilidades e os limites decorrentes da incorporação da Agenda 2030 da ONU pelo Poder Judiciário Nacional,  precisamente no tocante ao ODS 16. Primeiramente, elencamos alguns dos principais aspectos normativos referentes à adesão a essa pauta e a recepção do PNUD como consectários da preocupação do órgão de cúpula da Justiça Brasileira com a qualidade e aprimoramento da entrega jurisdicional. Prosseguimos com uma análise crítica da pretensão de universalidade da visão ocidental de direitos humanos, relacionando-a com o conceito de colonialidade do poder, de Quijano (1992). Em seguida, problematizamos o conceito de desenvolvimento que subjaz o ODS em questão, tomando em conta o capitalismo estruturalmente dependente que caracteriza a nossa região, como também os paradoxos do crescimento econômico enquanto critério implícito na pauta onusiana. Finalmente, diante dessas reflexões e considerando os limites das concepções hegemônicas de direitos humanos e desenvolvimento, discutimos algumas condicionantes estruturais, contextuais e interseccionalidades que desafiam a construção de novas metodologias, mediações e ferramentas que possam permitir a integração dessa pauta pelo Judiciário. Apontamos alguns possíveis caminhos horizontais, dialógicos, transmodernos e pluriversais, coerentes com as particularidades, as contradições materiais e as especificidades da realidade brasileira.