bluuebunny/crossref_metadata_2025 huggingface dataset:
Penerapan Keamanan Owasp Terhadap Aplikasi GTFW Pada Website Universitas Battuta
Authors: Harahap Baginda
Published: March 2023

In this study, we will test the penetration of GTFW-based applications that have been carried out, then obtain the results as a session management category vulnerability test, namely 3 that did not pass, namely cookie attributes, CSRF, and session timeout, then the vulnerability of the input validation category there was 1 that did not pass, namely stored XSS. The xplorin application has a cookie attribute vulnerability with a Medium vulnerability risk level. The xplorin application has a CSRF vulnerability with a Medium vulnerability risk level. The xplorin application has a session timeout vulnerability with a Low vulnerability risk level. The xplorin application has a stored XSS vulnerability with a Low risk level of vulnerability.
Pengembangan Sistem E-Elearning Berbasis Kurikulum Tingkat Satuan Pendidikan Di SMAN 1 Talawi
Authors: Nisa Sukria Hairun , Ahmad Diva Sri Wahyuni , Wulandari Ria , Febrian M. Fauzan
Published: March 2023

Penelitian ini menerangkan menganai sebuah pengambangan sistem E-learning Berbasis Kurikulum Tingkat Satuan Pendidikan yang dikembangkan dengan tujuan untuk menyediakan sebuah media pembelejaran berbasis web yang digunakan sebagai komplemen diluar jam pembelajaran bagi guru dan siswa. Sistem yang dikembangkan dalam penelitian ini menonjolkan aspek perencanaan pembelajaran yang baik sesuai dengan kurikulum satuan pendidikan yang digunakan di Indonesia  ditambah dengan fitur-fitur standar seperti yang ada pada Learning Manajament System untuk tercapainya kegiatan pembelajaran. Penelitian ini juga bertujuan untuk mengetahui respon dan penilaian guru dan siswa mengenai sistem yang dikembangkan serta kelayakan dari sistem nya. Tujuan penelitian ini yaitu untuk mengetahui bagaimana pengembangan sistem e-learning berbasis kurikulum tingkat satuan Pendidikan SMAN 1 Talawi. Penelitian ini menggunakan metode kepustakaan. E-learning digunakan untuk proses pembelajaran melalui media elektronik yang digunakan oleh peserta didik dan pendidik. Kurikulum tingkat satuan pendidikan digunakan untuk mewujudkan kurikulum yang sesuai dengan kondisi, potensi kebutuhan dan permasalahan. Dari penelitian ini didapatkan hasil (1) hampir seluruh siswa memberikan respon yang cukup baik, (2) dari 2 guru yang mencoba sistem secara langsung didapatkan penilaian yang dapat dikategorikan baik, (3) tingkat kelayakan sistem yang diberikan oleh ahli sistem setelah melalui perbaikan dikategorikan sangat tinggi.
Pengaruh Teknologi Terhadap Perkembangan Islam di Era Remaja Milenial
Authors: Putri Meuthia , Lestari Rizki Dwi , Matondang Salsabila , Sunardi Nirzal
Published: March 2023

Teknologi memberi dampak bagi kehidupan.Pada tingkat teoritis teknologi mempengaruhi pola berpikir dan juga berdampak pada tindakan .Perkembangan yang di bawa oleh teknologi tidak hanya berdampak pada kehidupan di pusat kota,tetapi jugak masuk ke pedesaan.Di sisi lain teknologi memberi pemerataan informasi dalam bentuk demokratisasi data serta informasi.Dalam islam ,sumber informasi di buat oleh otoritas dengan kualifikasi khusus.Sementara itu teknologi membuat otoritas menjadi transparan .Fenomena keagamaan yang muncul sangat beragam sesuai dengan tingkat paparan teknologi yang terjadi di lingkungan.Dengan demikian yang menjadi landasan utama penelitian mengenai dampak teknologi terhadap perkembangan islam,khususnya pada studi kasus remaja milenial .Penulis menemukan adanya perubahan pemahaman yang berkenaan dengan aspek fundamental dalam islam yang sebelumnya bertitik fokus pada otoritas kea rah tekno-teologis dalam bentuk dan akse-aksenya yang baru.
Insults within National Criminal Law and Islamic Criminal Law: Sanctions Perspective and Legal Developments Review
Authors: Banjarani Desia Rakhma , Putri Taufani Yunithia , Zulaikha Almira Novia
Published: March 2023

Insults are a common issue in society, yet it is crucial that the honor, dignity, and respect of all individuals are maintained and shielded from any form of disturbance or insult attempts, as guided by both Islamic provisions and state law. This research aims to explore two primary questions: What are the sanction provisions for insults within Indonesian law? And, how has Islamic criminal law evolved in addressing insult crimes in Indonesia? A normative research method is employed, drawing on both primary and secondary data sources. The primary source is Law Number 1 of 2023 on the Criminal Code, with secondary data derived from related books and articles. Indonesian law, through Law Number 1 of 2023, outlines sanctions for insult crimes, identifying 8 types of insulting behaviors, alongside the Information and Electronic Transactions Law (ITE Law). In Islamic criminal law, regulations are grounded in the Al-Qur'an and authentic Hadiths: Muttafaq alaih. Islamic criminal law's approach to insult crimes utilizes Takzir punishment, also known as jarimah Takzir, highlighting the adaptability of Islamic legal principles in contemporary judicial considerations, allowing judges to apply Takzir punishment provisions in their rulings.
Judges' Considerations in Determining the Sentences for Narcotics Abuse Category I
Authors: Darmawan Dimas Didi
Published: March 2023

The rise in drug-related arrests in Indonesia has increasingly implicated the younger generation, highlighting the urgent need for appropriate legal responses. Narcotics, which include both naturally derived and synthetic substances, have the capacity to alter consciousness, reduce or eliminate pain, and create dependency. In the legal context, while rehabilitation serves as a potential corrective measure, aimed at treating the drug users rather than solely punishing them, it is underutilized. Instead, judicial practices often lean towards imposing prison sentences and fines. This empirical normative legal research draws on both primary and secondary data, collected through fieldwork and library research, to explore these judicial decisions. The research focuses on how judges apply Article 127, paragraph 1, letter a of Law Number 35 of 2009 (Narcotics Law) in determining the guilt of defendants and deciding their sentences. A case research from the Special Class II Gedong Tataan District Court demonstrates that judicial decisions predominantly favor incarceration and fines, often due to the lack of established evidence that the defendants are drug addicts or victims of drug abuse, thus not qualifying them for rehabilitation. This research underscores the need for a critical reassessment of sentencing practices to better address the rehabilitation needs of drug offenders, particularly the youth.
Equally Public and Private Refugee Resettlement: The Historical Development of Canada’s Joint Assistance Sponsorship Program
Authors: McNally Rachel
Published: March 2023

For over 40 years, Canada’s Joint Assistance Sponsorship Program has combined government financial assistance, professional settlement services, and private sponsor settlement support for refugees identified as having “special needs.” With high public and private involvement, the program offers another potential model for sponsorship, yet existing knowledge about the program is limited. This article explores the historical development of the program, highlighting three time periods: 1979–1981, when it launched; 1998–2001, when it welcomed thousands of Kosovars and expanded as selection criteria prioritized vulnerability; and 2014–2019, as it increasingly competed with other sponsorship programs.
ANÁLISE DA AVALIAÇÃO DE DESEMPENHO DE FUNCIONÁRIOS NO TRABALHO REMOTO - UM ESTUDO DE CASO NA UNIVERSIDADE FEDERAL DA INTEGRAÇÃO LATINO-AMERICANA – UNILA
Authors: Luiz Jéssica Damian , Costa Mariana Soares , Petri Sergio Múrilo , Martins Vinícius Abílio
Published: March 2023

Vivemos numa sociedade em constante mudança, sendo deste modo necessário que as organizações estejam bem estruturadas e se adaptem rapidamente aos imprevistos. Um bom exemplo do mesmo, é a pandemia que todo o mundo enfrenta, a covid-19, que obriga as organizações a repensarem tanto as suas estratégicas como as suas práticas. Neste artigo, será analisado como foi desenvolvida a avaliação de desempenho dos funcionários de uma Universidade Federal durante o teletrabalho e identificar melhorias para o processo, por meio de um estudo de caso na Universidade Federal da Integração Latino-Americana – UNILA. A natureza deste estudo é exploratória, descritiva e de abordagem qualitativa, os dados, em vez de serem numéricos, são textuais, e cabe ao pesquisador interpretar e classificar. Como resultados encontrados, percebeu-se a importância em avaliar a motivação, satisfação e adaptabilidade dos funcionários quanto ao trabalho remoto e de realizar a gestão de talentos. Foi identificada a necessidade de criar subcritérios para os critérios avaliativos e de atribuir pesos a eles para que seja possível visualizar a importância de cada um na avaliação do desempenho. Também foi sugerido a criação de nível de complexidade e tempo de execução das atividades para uma das ferramentas utilizadas.
Faktor-Faktor yang Berhubungan dengan Kejadian Dismenore Primer Pada Mahasiswi Institut Pertanian Bogor
Authors: Fachruddin Kadija Raisa , Anwar Faisal , Dwiriani Cesilia Meti
Published: March 2023

Penelitian ini bertujuan menganalisis faktor-faktor yang berhubungan dengan kejadian dismenore primer pada mahasiswi Institut Pertanian Bogor (IPB). Desain penelitian ini adalah cross sectional study, melibatkan 97 subyek. Pengambilan data dilakukan secara online melalui pengisian kuesioner Google Form (data karakteristik dan aktivitas fisik subyek) dan wawancara melalui voice call (data riwayat asupan). Sekitar 2/3 subyek (69.1%) mengalami dismenore primer terutama tingkat 1 (49.5%). Sekitar 2/3 subyek (68%) memiliki ibu yang tidak mengalami dismenore. Hampir 2/3 subyek yang mengalami dismenore primer (61.2%) merasa terganggu aktivitas belajarnya saat mengalami dismenore. Sekitar separuh subyek (51.5%) memiliki asupan energi kurang, 4/5 subyek (81.4%) memiliki kecukupan karbohidrat kurang dan hampir separuh subyek (47.4%) memiliki kecukupan lemak lebih. Sebagian besar subyek memiliki asupan zat gizi mikro kurang kecuali vitamin A. Terdapat hubungan yang signifikan antara dismenore primer dengan riwayat dismenore ibu (p<0,05). Terdapat hubungan yang signifikan antara nilai status gizi dengan jumlah asupan energi (p=0.007, r=-0.271) dan karbohidrat (p=0.005, r=-0.283). Terdapat hubungan yang signifikan antara gangguan belajar akibat dismenore primer dengan tingkat intensitas dismenore (p=0.000).
Proyeksi Produksi Daging Ayam Ras untuk Memenuhi Kebutuhan Protein Penduduk di Indonesia
Authors: Swamilaksita Prita Dhyani , Sukandar Dadang
Published: March 2023

Penelitian ini dilakukan untuk menganalisis forecasting produksi daging ayam ras untuk memenuhi kebutuhan protein penduduk di Indonesia. Penelitian ini dilakukan dengan menggunakan metode penelitian kuantitatif deskriptif dengan pendekatan Analisis Data Sekunder (ADS) secara time series. Penelitian dilaksanakan dari bulan April-Juni 2022. Populasi yang digunakan dalam penelitian adalah seluruh data time series produksi daging ayam ras di Indonesia selama periode 2000-2021 dan data jumlah penduduk Indonesia 2010 dan 2020. Pengolahan data dalam penelitian menggunakan Microsoft Excel, beberapa metode peramalan yang digunakan untuk analisis produksi antara lain rata-rata bergerak (Moving Average–MA), Weight Moving Average (WMA), pemulusan atau penghalusan eksponensial SES (Single Exponential Smoothing), dan DES (Double Exponential Smoothing). Proyeksi jumlah penduduk dianalisis menggunakan metode geometri. Hasil analisis proyeksi produksi daging ayam ras bahwa terjadi peningkatan pada periode 2000-2024 seiring dengan peningkatan jumlah penduduk. Metode yang paling baik untuk melakukan peramalan produksi daging ayam ras yaitu exponensial smoothing dengan SES karena memiliki MAPE 10-20% dan nilai eror yang paling kecil. Apabila dilihat dari kontribusi terhadap konsumsi maka diketahui proyeksi produksi belum mampu memenuhi konsumsi penduduk kg per kapita per tahun karena beberapa penelitian masih banyak menyebutkan ketergantungan Indonesia akan impor daging ayam ras.
Hubungan Kualitas Tidur, Asupan Zat Gizi Makro dan Aktivitas Fisik dengan Status Gizi Mahasiswa Gizi UMJ
Authors: Febytia Nechita Dinda , Dainy Nunung Cipta
Published: March 2023

Pada usia dewasa, aktivitas fisik dapat menjadi lebih tinggi dan hal tersebut memicu terjadinya perubahan pada metebolisme seiring dengan peningkatan usia. Pada usia ini, individu rentan mengonsumsi asupan makanan dalam jumlah yang berlebihan, perubahan gaya hidup, tekanan lingkungan yang tinggi, kurang berolahraga, dan stress yang tinggi yang dapat memicu terjadinya perubahan pada pola makan, sehingga dapat menyebabkan masalah gizi. Tujuan penelitian ini adalah mengetahui hubungan antara kualitas tidur, asupan zat gizi makro dan aktivitas fisik mahasiswa Program Studi Ilmu Gizi UMJ dengan status gizi. Desain penelitian ini adalah cross sectional dengan jumlah subjek 52 orang mahasiswa. Kualitas tidur diukur menggunakan kuesioner Pittsburgh Sleep Quality Index (PSQI), Asupan zat gizi makro diukur dengan food recall 1x24 jam, dan aktivitas fisik diukur dengan kuesioner Physical Activity Level (PAL). Analisis statistik menggunakan uji Fisher Exact Probability Test. Hasil penelitian menunjukkan terdapat hubungan signifikan antara asupan lemak dan aktivitas fisik dengan status gizi (p<0,05), namun tidak terdapat hubungan antara kualitas tidur, asupan energi, asupan protein dan karbohidrat dengan status gizi.
Compreendendo o conceito de robótica pedagógica a partir de concepções ligadas à cibernética
Authors: Madureira Luso Soares
Published: March 2023

Objetivo: Compreender de maneira contextualizada, o conceito de robótica pedagógica através de uma reflexão sobre alguns dos principais conceitos ligados ao campo da cibernética. Revisão bibliográfica: A cibernética é a teoria geral que estuda os sistemas que controlam irrestritamente as máquinas. Contudo, por falta de uma perspectiva crítica da realidade, tais estudos têm trilhado caminhos escorregadios e ideológicos. Estes estudos, majoritariamente, têm influenciado a distorção de conceitos ligados a robótica pedagógica, pois dão a entender que o conceito em torno da robótica pedagógica está vinculado apenas a questões funcionais e isto, de maneira sorrateira, tem contribuído para uma distorção do contexto social, no sentido de tentar anular a essência dos homens e de todo o resultado da sua historicidade, comparando-os e colocando-os abaixo das máquinas tecnológicas. Portanto, a partir de algumas discussões, é possível atestar que a robótica pedagógica não se resume a um artefato, pois ela representa um conjunto de processos e procedimentos que utiliza de artefatos robóticos pedagógicos. Considerações finais: Essa perspectiva conceitual sobre a robótica pedagógica é de grande relevância, pois resgata a ressignificação dos papéis e das relações sociais entre o ser humano e os artefatos tecnológicos dentro e fora do ambiente educacional.
Análise das características das Espondiloartrites Axiais
Authors: Franco Luiz Gustavo Mayrink de Moura , Souza Renan Lopes de , Siqueira Emílio Conceição de
Published: March 2023

Objetivo: Analisar as características da Espondiloartrite Axial radiográfica (r-axSpA) ou Espondilite Anquilosante (EA) e não radiográfica (nr-axSpA). Revisão bibliográfica: A espondiloartrite axial é uma doença inflamatória contínua que varia de axSpA não radiográfica a axSpA radiográfica. A condição é definida pelo envolvimento da articulação axial, muitas vezes sacroileíte associada a artrite periférica e envolvimento extra-articular (uveíte, doença inflamatória intestinal, entesite e psoríase. Um sintoma clássico e chave da axSpA é a dor inflamatória nas costas (IBP). Os sintomas de axSpA criam um fardo significativo para os pacientes e para a sociedade, pois interferem significativamente na qualidade de vida. Considerações finais: A axSpa é uma doença reumatológica cuja prevalência é de 1,4% e que pode interferir nas atividades diárias dos pacientes. Dessa forma, o tratamento objetiva diminuir a atividade da doença e prevenir incapacitação, melhorando a qualidade de vida do portador. O manejo da doença inclui AINEs como primeira opção terapêutica seguido pelos biológicos e outros medicamentos anti-reumáticos modificadores da doença. Ademais, o tratamento não farmacológico baseado em fisioterapia e exercícios físicos também é indicado além da educação do paciente acerca da condição.
Scrotal migration of peritoneal end of ventriculoperitoneal shunt in an infant – A rare entity
Authors: Chanchlani Roshan , Sharma Pramod Kumar , Gunasekaran Vidhya , Kasundra Ankit
Published: March 2023

Ventriculoperitoneal shunt migration into the scrotum is a rare phenomenon that has been reported in nearly 35 patients in the literature till date. Genitalia-related complications of ventriculoperitoneal shunts in children like inguinoscrotal migration usually occur during 1st year of the shunt procedure due to factors like raised abdominal pressure and patency of process vaginalis. We report a case of scrotal migration of tip of ventriculoperitoneal shunt in a 2-month-old infant presenting to us with communicating hydrocephalus. In a patient with inguinoscrotal swelling and ventriculoperitoneal shunt, migration of shunt should be suspected. Prompt diagnosis and management of this condition is important due to various complications like shunt dysfunction and testicular lesions. Treatment of this condition is surgical closure of the patent processes vaginalis and shunt reposition.
Antegrade and Retrograde Crossing of Chronic Total Occlusions Using the Outback Re-entry Device
Authors:   University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, Clark Timothy , Vance Ansar , Mantell Mark , Reddy Shilpa , Shackles Christopher
Published: March 2023

Purpose. The Outback device (Cordis) enables true lumen re-entry during subintimal recanalization of chronic total occlusions (CTOs). This study compared outcomes of patients who underwent subintimal recanalization of lower-extremity arterial CTOs utilizing the Outback device via antegrade and retrograde approaches. Methods. A retrospective analysis identified 39 patients with Rutherford 3 (n = 13), 4 (n = 13), and 5 disease (n = 13) where the Outback device was utilized (19 antegrade crossing femoropopliteal CTOs, 20 retrograde [17/20 transpedal access crossing femoropopliteal/tibioperoneal CTOs, 3/20 femoral access crossing iliac CTOs]) after conventional techniques failed. Mean age was 70.5 years and 67% were men. Most patients had multifocal and/or long-segment occlusions, with 41% having combined above- and below-knee disease. Results. Overall technical success was 90% (95% antegrade and 85% retrograde cohort; P=.15). There were no major complications and 4 minor complications (prolonged bleeding, femoral pseudoaneurysm requiring thrombin injection, and 2 small access-site hematomas). Fifteen percent of the retrograde cohort subsequently underwent distal bypass, compared with 0% in the antegrade cohort (P=.23). A single amputation occurred, in the antegrade group. Twelve-month target-vessel unassisted primary patency was higher with antegrade use (76% in the antegrade group vs 48% in the retrograde group; P=.03), but 12-month assisted primary patency was similar (85% in the antegrade group vs 79% in the retrograde group; P=.85). Conclusion. The Outback can be used safely and effectively from both antegrade and retrograde approaches during recanalization of CTOs. Lower target-vessel unassisted primary patency using the retrograde transpedal approach indicates the need for closer surveillance to achieve high rates of limb salvage.
Single-Center Experience With Optical Coherence Tomography-Guided Directional Atherectomy System for Below-the-Knee Critical Limb Ischemia
Authors:   Einstein Medical Center, Memon Sehrish
Published: March 2023

BACKGROUND. Below-the-knee (BTK) peripheral arterial disease (PAD) more often presents as critical limb ischemia. Endovascular revascularization strategies continue to evolve to achieve long-term limb-salvage outcomes. A single-center experience with optical coherence tomography (OCT)-guided atherectomy using Pantheris SV (Avinger) is reported. METHODS. All patients with PAD in femoropopliteal or infrapopliteal vessels (n = 27) who underwent plaque debulking by Pantheris SV were analyzed retrospectively. Baseline comorbidities, Rutherford classification, lesion length and characteristics, adjunctive treatment strategy, device-related failures/complications, and major adverse events were analyzed. Additionally, 6-month target-lesion revascularization (TLR) rate was available for 21 of 27 patients. RESULTS. Mean patient age was 70.5 years, 16 patients (59%) were women, and 19 patients (70%) had Rutherford class 5 to 6 symptoms. A total of 58 vessels were treated, including 32 iliofemoropopliteal and 26 infrapopliteal vessels. Chronic occlusions were present in 19% of iliofemoropopliteal lesions and 17.2% of infrapopliteal lesions. The most commonly treated BTK lesion (12 of 26) was the anterior tibial artery (ATA). Following atherectomy, 21 were treated with angioplasty, 4 with angioplasty followed by coronary drug-eluting stent (DES), and 1 with cutting balloon and laser atherectomy. Four failures/complications occurred; 3 of these were device related (failure to pass through lesion due to proximal ATA angulation, coronary DES dislodgment while treating BTK in-stent restenosis, and 1 requiring laser atherectomy for no-flow post atherectomy and angioplasty). At 6 months, 2 of 21 patients (9.5%) required revascularization interventions. CONCLUSION. Treatment of BTK-PAD with imaging guided Pantheris SV atherectomy device appears to be safe, with low rate of TLR at 6 months. Future multicenter randomized trials are needed to confirm these findings.
The prospects for the diagnosis of optic neuritis in neuromyelitis optica
Authors:   S. Fyodorov Eye Microsurgery Federal State Institution, Moscow, Russian Federation, Ioyleva E.E. , Safonenko A.Y. ,   S. Fyodorov Eye Microsurgery Federal State Institution, Moscow, Russian Federation, Golubeva O.V. ,   S. Fyodorov Eye Microsurgery Federal State Institution, Moscow, Russian Federation, Potykun I.V. ,   S. Fyodorov Eye Microsurgery Federal State Institution, Moscow, Russian Federation, Mitrofanov A.M. ,   S. Fyodorov Eye Microsurgery Federal State Institution, Moscow, Russian Federation
Published: March 2023

The review presents data on the prospects for the diagnosis of optic neuritis in neuromyelitis optica (NMO). The differential diagnosis of NMO with multiple sclerosis and other autoimmune diseases is complicated by the similarity of the clinical manifestations of optic neuritis. The diagnostic approach, tactics of using and interpreting the results of modern laboratory, instrumental and hardware research methods are described. Additional diagnostic criteria are described for AQPR4-IgGseronegative patients with clinical symptoms of acute urinary tract infections. NMO is characterized by severe unilateral damage to the optic nerve with poor recovery of visual functions after conservative therapy, frequent recurrences of optic neuritis in one or both eyes, bilateral simultaneous damage to the optic nerves or chiasm. Timely diagnosis makes it possible to prescribe pathogenetic therapy for NMO and reduce the number of relapses of optic neuritis and prevent patients’ blindness. Key words: neuromyelitis optica, optic neuritis, OCT, multiple sclerosis, neuromyelitis optica spectrum disorders, AQPR4
Sandwiching textiles with FDM Printing
Authors: Özev Mahmut-Sami , Ehrmann Andrea
Published: March 2023

3D printing on textile fabrics has been investigated intensively during the last years. A critical factor is the adhesion between the printed polymer and the textile fabric, limiting the potential areas of application. Especially safety-related applications, e.g. stab-resistant textile/polymer composites, need to show reliable adhesion between both components to serve their purpose. Here we investigate the possibility of sandwiching textiles between 3D-printed layers, produced by fused deposition modeling (FDM). We show that adding nubs to the lower 3D-printed layers stabilizes the inner textile fabric and suggest future constructive improvements to further enhance the textile-polymer connection.
Geographical space of G.V. Ksenofontov’s research
Authors: Пахомова Л.С.
Published: March 2023

В статье рассматривается экспедиционная деятельность известного якутского ученого-филолога, этнографа Г.В. Ксенофонтова, который первым взглянул с научной точки зрения на происхождение якутов – местообитания предков якутского народа. Научные труды Г.В. Ксенофонтова исследованы довольно подробно, опубликовано множество научных исследований филологов, историков, этнографов и краеведов и не теряют своей актуальности. Но его научные исследования имеют востребованность и в других науках, в частности имеют тесную связь с географией. Географический и пространственный подходы к научным исследованиям ученого обозначили маршрутные этнографические экспедиции в аспекте географического пространства. Актуальность заключается в описании территорий этнографических экспедиций Г.В. Ксенофонтова, которые были проведены в 1921–1926 гг., как маршрутные полевые исследования на географическом пространстве Восточной Сибири. Объект и предмет исследования: научная деятельность Г.В. Ксенофонтова и описание маршрутов экспедиционной деятельности по междуречью рек Енисей и Лена. Материалы и методы Обзор научной литературы позволил раскрыть ключевые вопросы по теме статьи: понятие географического пространства обосновано на исследованиях Э.Б. Алаева, Ю.Н. Гладкого, В.Д. Сухорукова [1, 2, 3]; монография А.И. Дьячковой [4, 8] и другие источники раскрыли сведения о личной, общественной и научной деятельности Г.В. Ксенофонтове; деятельность ученого в ВСОРГО и Якутском отделе РГО основана на работах А. Мальковой [7], Ю.А. Зуляр Л.М. Корытного [10], и др. В исследовании применены методы анализа и обобщения, исторический, сравнительный и картографический методы при рассмотрении маршрутов экспедиций на географическом пространстве. Анализ работы Г.В. Ксенофонтова «Легенды и рассказы о шаманах у якутов, бурят и тунгусов (материалы к мифологии урало-алтайских племен в Северной Азии» [9] обозначил основные маршруты по территориям. В результате автором определены территории и события научной экспедиционной деятельности ученого как географическое пространство. Экспедиционная деятельность Г.В. Ксенофонта во время полевых экспедиций обобщена в 4 таблицах и разработана карта маршрутов четырех экспедиций протяженностью 8 тыс. км, охватив территорию около 2 млн. кв. км. на географическом пространстве Восточной Сибири.
Thromboelastometry-Guided Therapy of Fulminant Coagulopathy during C-Section and Amniotic Fluid Embolism
Authors:   Department of Anesthesiology, Intensive Care and Pain Medicine, University Hospital Münster, Germany, R Weiss , TC Von Groote ,   Department of Anesthesiology, Intensive Care and Pain Medicine, University Hospital Münster, Germany, SD Schäfer ,   Department of Gynecology and Obstetrics, University Hospital Münster, Germany, M Keller ,   Department of Anesthesiology, Intensive Care and Pain Medicine, University Hospital Münster, Germany
Published: March 2023

This article describes the emergency case of a mid-thirty-year-old pregnant woman who suffered the rare obstetric complication of an amniotic fluid embolism, resulting in fulminant Disseminated Intravascular Coagulopathy (DIC) and shock. DIC was diagnosed with Thromboelastometry (TEM) and therapy was consequently guided by TEM. Thromboelastometry is a viscoelastic hemostatic assay that enables assessment of different aspects of whole blood clot formation under shear stress. This technique is increasingly used in anesthesia and critical care to guide hemostatic therapy. This report underlines the importance of TEM-monitoring of hemostatic complications such as DIC.
Swyer’s Syndrome: Discordance between Genetic and Biological Sex - Case report
Authors:   Clinic of Endocrinology and Metabolism, School of Medicine, Hospital of Clisnics, Manuel Quintela, University Republic (UdelaR), G Aldao , G Mintegui ,   Clinic of Endocrinology and Metabolism, School of Medicine, Hospital of Clisnics, Manuel Quintela, University Republic (UdelaR), P Agüero ,   Clinic of Endocrinology and Metabolism, School of Medicine, Hospital of Clisnics, Manuel Quintela, University Republic (UdelaR)
Published: March 2023

Swyer’s syndrome is a rare condition in which a disorder of the sex chromosomes produces a defective gonadogenesis with total absence of functional gonadal tissue, resulting in pure gonadal dysgenesis and discordance between genetic and biological sex. The gonads appear as rudimentary bands and the risk of developing gonadal tumors is significant. The etiology is not clear: one of the possible causes is the absence or mutations of the SRY gene located on the Y chromosome. This gene is considered to be the most important, although it is known that there are other genes involved in the cascade of sexual differentiation. This article reports the case of a 17-year-old female phenotype patient who was studied for primary amenorrhea and presented laboratory findings compatible with hypergonadotropic hypogonadism, 46XY karyotype, who was diagnosed with Swyer Syndrome.
UPLC-QTOF-MS-Based Metabolomics Reveal the Effect of Polysaccharides from Danggui-Shaoyao-San in Type 2 Diabetic Male and Female Rats
Authors:   Key Laboratory of Basic and Application Research of Beiyao, Ministry of Education, Heilongjiang University of Chinese Medicine, China, F Xin , L Si-Han ,   Key Laboratory of Basic and Application Research of Beiyao, Ministry of Education, Heilongjiang University of Chinese Medicine, China, L Jia-Jun ,   Key Laboratory of Basic and Application Research of Beiyao, Ministry of Education, Heilongjiang University of Chinese Medicine, China, W Zhi-Bin ,   Key Laboratory of Basic and Application Research of Beiyao, Ministry of Education, Heilongjiang University of Chinese Medicine, China
Published: March 2023

Background: Type 2 Diabetes Mellitus (T2DM) is currently one of the most prominent and global chronic conditions. In recent years, it has been found that macromolecular polysaccharide has a significant effect on T2DM, various polysaccharides such as Angelica Sinensis Polysaccharide (ASP), Poriacocos polysaccharide and Atractylodesmacrocephala polysaccharide in DSS have effects on T2DM, but mechanism of polysaccharides of DSS(p-DSS) at the metabolic level is still unclear. The purpose of this work is to study the male and female mechanisms of p-DSS in treating T2DM based on metabolomics. Materials and Methods: In this study, metabolomics was used to elucidate the therapeutic mechanism of DSS in T2DM. Urinary samples were collected from male and female rats with T2DM, induced by a high-sugar and high-fat diet combined with Streptozotocin (STZ), to measure the levels of biochemical markers. Urinary metabolomics-based analysis using ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF-MS) was conducted to evaluate the differential metabolites from multiple metabolic pathways. Results: After treatment with p-DSS for 4 weeks, biochemical indicators, including Fasting Blood Glucose (FBG), Fasting Insulin (FINS), Oral Glucose Tolerance Test (OGTT), Insulin Tolerance Test (ITT) and Homeostasis Model Assessment of Insulin Resistance (HOMA-IR), were significantly improved. Metabolomics results revealed that p-DSS regulated the biomarkers, such as PC, 2-oxoglutarate, NAAG in TCA cycle and alanine, aspartate and glutamate metabolism for male rats, on the contrary, leukotriene B4, cholic acid in arachidonic acid metabolism and primary bile acid biosynthesis for female rats. Conclusions: Based on metabolomics, the mechanisms of p- DSS in male and female rats are not identical.
Energetic and Kinetic Origin of CALB Interfacial Activation Revealed by PaCS-MD/MSM
Authors: Wijaya Tegar , Kitao Akio
Published: March 2023

Conformational dynamics of Candida antarctica Lipase B (CALB) was investigated by molecular dynamics (MD) simulation, parallel cascade selection MD (PaCS-MD), the Markov state model (MSM), and mainly focused on the lid-opening motion closely related to substrate binding. All-atom MD simulation of CALB was conducted in water and that around the interface constructed by water and tricaprylin. CALB initially situated in water and separated by layers of water from the interface is spontaneously adsorbed onto the tricaprylin surface during MD simulation. The opening and closing motions of the lid are simulated by PaCS-MD and subsequent MSM analysis provided the free energy landscape and time scale of the conformational transitions among the closed, semi-open, and open states. The closed state is the most stable in the water system but the stable conformation in the interface system shifts to the semi-open state. In the interface system, the transition probability to the open state is higher than in the water system. These effects could explain the energetics and kinetics origin of previously reported interfacial activation of CALB. We also suggest two types of mechanisms for substrate binding in which small and hydrophilic substrates bind without interfacial activation while large and bulky substrates bind via interfacial activation. These findings could help expand the application of CALB towards a wide variety of substrates.
High-throughput crystallography for rapid fragment growth from crude arrays by low-cost robotics
Authors: Grosjean Harold , Aimon Anthony , Hassell-Hart Storm , Thompson Warren , Koekemoer Lizbé , Bennett James , Anderson Cameron , FitzGerald Edward A , Krojer Tobias , Bradley Anthony , Fedorov Oleg , Biggin Philip C. , Spencer John , von Delft Frank
Published: March 2023

We demonstrate that a simple workflow of array synthesis, combining low-cost robotics with analytic techniques to deconvolute crude reaction mixtures, is an effective way to collect structural data on a binding site. Starting from the high information content of the crystallographic fragment screens on PHIP(2) (second bromodomain of the pleckstrin homology domain interacting protein), a collection of more than 1800 compounds was enumerated. Several thousand Crude Reaction Mixtures (CRMs) were synthesized on one robotic platform, an OpenTrons OT-1 liquid handler, using reaction sequences of up to 5 chemical steps. Analysis via MScheck, an algorithm-based system for finding an m/z in a CRM, significantly shortened product identification protocol times. 969 usable X-ray diffraction datasets were acquired, which resolved as 22 reaction products binding to the protein, 19 with conserved poses relative to the original fragment and 3 with a new, unexpected binding pose. The 22 crystallographic hit compounds were subsequently tested with peptide displacement alpha-screen assay and time-resolved grating-coupled interferometry-based biosensor assays, which confirmed one molecule with an IC50 = 34 μM and KD = 50 μM, from an inactive fragment. The procedures described are entirely formulaic and engineerable and the method is eminently scalable. We anticipate that this cheap, low solvent-use approach will yield vast amounts of data, enabling rapid structural SAR landscape exploration around fragments, leading to faster fragment-to-lead times.
Exploring the Stability and Disorder in the Polymorphs of L-Cysteine through Density Functional Theory and Vibrational Spectroscopy
Authors: Kendrick John , Burnett Andrew
Published: March 2023

Static and dynamic density functional calculations are reported for the four known polymorphs of L-Cysteine. Static calculations are used to explore the relative free energies (within the harmonic approximation) of the polymorphs as a function of pressure. An important feature of the structural differences between the polymorphs is shown to be the dihedral angle of the C-C-S-H bond. It is shown that by varying this angle it is possible to move between hydrogen bonding motifs S-H...S and S-H...O in all four polymorphs. The energetics for dihedral angle rotation are explored and the barriers for rotation between the hydrogen bonding motifs have been calculated for each polymorph. Two possible models for the experimental disorder observed in Form I at room temperature are explored using both static and dynamic methods; a domain disorder model, where the disorder is localised, and a dispersed disorder model, where the disorder is randomly distributed throughout the crystal. Molecular dynamics calculations show transitions between the two hydrogen bonding motifs occurring in the dispersed disorder model at 300 K and 350 K. In addition, molecular dynamics calculations of Form IV also showed the onset of hydrogen bond disorder at 300 K. Calculations of the predicted infrared and terahertz absorption are performed for both the static and dynamic simulations and the results compared with experiment to understand the influence of disorder on the observed spectra.
On the Foreign Policy Rhetoric of Hyper-Postmodernism
Authors:   Institute of Scientific Information for Social Sciences RAS, Tsibizova I. M.
Published: March 2023

Contemporary Western foreign policy rhetoric is defined as hyper-postmodern. The cliche “Putin's inflation” is shown as the result of the exclusion of the necessary logical link, flawed logic or its complete absence. At the same time, it is a “strong” metaphor used as a semiotic icon in ideological rhetoric conducted in a strictly controlled media space – knowledge of the laws of semantics and advertising is inherent in experienced behind-the-scenes puppeteers standing behind the backs of politicians who are rather illiterate in geopolitical terms. Thanks to the method of ascent from the particular to the general, from real facts, the model of a “democratic” state is reproduced in the Western view. The resulting surreal picture has nothing to do with the classical definition of democracy, reminiscent of the Third Reich or an ideal state from the point of view of ISIS. This rhetoric is not logical and not pragmatic, as it is based on the ideology of hyper-moralism (A. Grau) – hypertrophied morality, not moral, having no other basis than itself and based on the “rules” it establishes. This rhetoric deserves the name of hyper-postmodernist, because it is hypertrophied and, surpassing the present, is not aimed at the future. If hyper-moralism, by extolling “gender diversity”, calls into question the continuation of the human race, hyper-postmodern foreign policy rhetoric and its continuation policies not only destroy the economy, but also threaten the future of the planet.
A two-way satisfaction model for sharing economy
Authors:   Universitat Internacional de Catalunya, Cueva Alejandra , Akhmedova Anna ,   Universitat Internacional de Catalunya, Marimon Frederic ,   Universitat Internacional de Catalunya
Published: March 2023

Customer satisfaction has been gaining the attention of researchers hoping to develop a model that integrates different constructs to achieve the satisfaction that leads to customer loyalty. Under the sharing economy paradigm, satisfaction is vital to the development of this disruptive business model. Trust between the consumer and the supplier allows its collaboration, and digital platforms connect the consumer with the supplier by creating a framework of trust around transactions. Producer satisfaction is as important as consumer satisfaction; however, it has not had the necessary attention— hence the need and motivation to develop a two-way review system. Based on the American Customer Satisfaction Index, we propose a cause-effect model for the consumer and supplier, connected by the common trust construct. Based on the literature review and choice of relevant publications, we define a conceptual model that will allow the development of a two-way satisfaction model to serve as a contribution to future satisfaction studies in the sharing economy.
Why is it worth studying economics? A course proposal for non-economics students
Authors:   Universitat Politècnica de Catalunya, Berbegal-Mirabent Jasmina , Carpi David ,   Universitat Internacional de Catalunya
Published: March 2023

At an early life stage, students must choose a degree, a crucial decision that will shape their professional life. Whatever the studies chosen, these are very topic specific, and the current higher education system does not have the mechanisms to make this choice less focused, allowing students to open their minds to other areas of knowledge. This situation is particularly critical for students who do not choose a major in a business-related discipline. Basic economic knowledge is paramount as it provides individuals with a better understanding of human behavior and the rules of the marketplace. Knowledge of its foundations is valuable for daily life (e.g. making better choices, allocating resources more effectively, and understanding policy options). However, in some countries, economics is compulsory at neither high school nor university; and thus, it is usually overlooked. Focusing on Spain’s particular context, this study underlines the key reasons for including economics in non-economic university programs. A survey gathering students’ perceptions of the fundamentals of economics and their level of understanding is presented and discussed. Building on the literature and the survey’s results, we identify three core blocks that should be taught. A panel of experts is consulted to evaluate our proposal.
Language and thought. (c2012)
Authors:   ,   Lebanese American University, El Jurdi Aleen
Published: March 2023

The relationship between language and thought has been a major area of discussion and debate for many philosophers, linguists, and researchers. While some considered that these two variables are separate faculties, others argued that they share many links and relationships. The study conducted in this research paper aimed at investigating whether there exists an influential relationship between language and thought. The participants were first year university students who viewed magazine images in the presence and absence of linguistic interference. Content analysis was done on the participants’ responses to an openended questionnaire which questioned the interpretation of the images. The findings of the study suggest that language has an evident impact on thought and cognition.
Artificial propagation of Asian catfish, Clarias batrachus (Linnaeus, 1758) in Asia: A review
Authors: Khan Abu Bakker Siddique , Akhter Mousumi , Modak Sunanda Rani
Published: March 2023

Clarias batrachus (Linnaeus, 1758) is a popular food fish of Indian sub-continent due to its high nutritional value. Earlier many workers have carried out studies on feeding and breeding biology of this fish species but convulsive information on the same is not available. So, a survey of published literatures on the induced breeding of C. batrachus has been carried out to consolidate the available information. Environmental factors play an important role in regulating reproduction in fishes. Pituitary gland extract, HCG and synthetic hormones viz., ovaprim and ova tide are successfully being tested for the induced breeding of fishes by various researchers under different climatic conditions, with varying degree of success. Chasm of information has been pointed out for further study mainly on age group wise variation in food preference and correlation of breeding periodicity with hydrological parameters and photoperiod.
Sosialisasi Pentingnya Internalisasi Nilai-Nilai Moderasi Beragama Melalui Semua Mata Pelajaran dalam Upaya Membangun Karakter Sosial Siswa SMP Negeri 1 Talun
Authors: Mustafa Mutakhirani
Published: March 2023

Tujuan penelitian ini, yakni menjelaskan pentingnya internalisasi nilai-nilai moderasi beragama dalam melakukan proses pembelajaran disetiap mata pelajaran tingkat sekolah menengah pertama. Penelitian ini menggunakan metode deskriptif kualitatif dengan pendekatan kualitatif case study . Sumber data penelitian yaitu berupa video pada saat melakukan sosialisasi di SMPN 1 Talun. Data penelitian yaitu berupa topik yang dijadikan bahan sosialisasi yang disampaikan oleh tim PkM berbasis riset. Teknik pengumpulan data berupa wawancara dan sejumlah dokumentasi baik visual maupun audio visual. Intrumen penelitian yaitu berupa vidio rekaman saat melakukan sosialisasi dan sejumlah foto-foto serta wawancara terstruktur dengan tim pelaksana PkM dan peserata. Kegiatan sosialisasi ini membuka cakrawala berfikir guru-guru bahwa pentingnya melakukan internalisasi nilai-nilai moderasi beragama dengan memberikan contoh secara langsung maupun melalui strategi dan metode pembelajaran. Semoga kedepan guru-guru melakukan pengembangan materi pembelajaran, kurikulum, silabus, rencana pembelajaran serta materi pembelajaran yang didesain menanamkan nilai-nilai moderasi beragama dalam rangka membentuk karakter sosial peserta didik.
Menjadi Relawan Kesehatan pada Bencana Gempa Bumi Cianjur
Authors: Abdurrasyid Abdurrasyid , Darmawan Dimas Fauzi , T Fransiskus Febri Juferta , Arare Khairina , Parangin-Angin Mayliana , Situmorang Rio Ardiyah
Published: March 2023

Relawan secara sederhana didefinisikan seorang yang meluangkan waktunya secara sukarela untuk memberikan kebaikan kepada sesama tanpa mengharapkan keuntungan. Pengabdian masyarakat bertujuan untuk mengetahui proses tahapan yang harus dilalui oleh mahasiswa yang akan menjadi relawan Universitas Esa Unggul, dan persiapan apa saja yang perlu dibawa oleh para relawan. Metode pelaksanaan yang akan digunakan untuk menjadi relawan di Desa Tunggilis, Kabupaten Cianjur, Jawa Barat dengan Kegiatan Abdi masyarakat Universitas Esa Unggul yang terdiri atas tahap registrasi, persiapan, dan pelaksanaan. Dengan menggunakan Metode menunjukan bahwa proses untuk menjadi relawan memiliki beberapa tahap diantaranya yaitu tahap pertama melakukan registrasi melalui ketua himpunan mahasiswa jurusan masing-masing prodi, tahap kedua yaitu pengarahan relawan penjelasan singkat tentang daerah bencana, tahap ketiga yaitu menyiapkan pelengkapan administrasi dan sarana pendukung yang harus dibawa oleh relawan. Selain itu menjadi relawan juga memiliki beberapa faktor yang mempengaruhi berjalanannya kegiatan relawan terdiri atas faktor pendukung pelaksanaan relawan dan faktor penghambat dari pelaksanaan relawan. Adapun saran untuk kedepannya perlu memperbaiki dan meningkatkan hubungan kerjasama yang baik dari relawan dari berbagai prodi, serta relawan perlu dibuat perencanaan yang lebih matang lagi dan persiapan apa saja yang diperlukan sebelum pelaksanaan program atau kegiatan relawan.
Sosialisasi Pemeliharaan Daerah Aliran Sungai (DAS) pada Masyarakat Berada di Das Kuranji Kota Padang
Authors: Jamilah Jamilah , Berd Isril , Junaidi Junaidi , Mizwar Zuherna , Nefilinda Nefilinda
Published: March 2023

Daerah aliran Sungai atau yang disebut DAS khususnya DAS Kuranji meruapakan semua kawasan yang akan mempengaruhi kualitas Batang Kuranji. Saat ini air pada Batang Kuranji mengalami peramsalahan yang serius, mulai dari debit air yang sangat fluktuatif antara musim hujan dan kemarau, terjadinya pendangkalan sungai di bagian hilir, intensifnya penambangan galian C di bagian Hulu dan Tengah Kawasan DAS, alih fungsi lahan yang sangat intensif di bagian Hulu DAS, sampah yang potensial merusak badan sungai dan lingkungan, semuanya menjadikan DAS semakin tidak sehat. Tujuan kegiatan adalah memberikan pemahaman pada masyarakat di kawasan DAS Kuranji pentingnya memelihara DAS untuk kehidupan yang bersinergi antara alam dan manusia secara kesinambungan. Kegiatan ini dilaksanakan selama 1 bulan dan 2 kali tiap minggu di 5 kecamatan yang berada dalam kawasan DAS Kuranji, yaitu Koto Tangah, Padang Utara, Nanggalo, Kuranji dan Pauh. Metode pelaksanaannya adalah dengan memberikan ceramah, diskusi (tanya jawab) dan buku program kerja FDAS Kota Padang pada Camat. Hasil kegiatan dapat disimpulkan bahwa Kegiatan sosialisasi memberikan dampak positif terhadap pemehaman masyarakat yang berada di dalam DAS Kuranji dalam upaya pemeliharaan DAS. Masyarakat mengharapkan kegiatan sosialisasidapat lebih intensif dilaksakan hingga ke kelurahan agar hasilnya jauh lebih efektif dibandingkan hanya di Kecamatan saja.