bluuebunny/crossref_metadata_2025 huggingface dataset:
Generalized Pareto Model: Properties and Applications in Neutrosophic Data Modeling
Authors: Khan Zahid , Almazah Mohammed M. A. , Hamood Odhah Omalsad , Alshanbari Huda M.
Published: September 2022

The Pareto distribution is widely used to model industrial, biological, engineering, and other various types of data. A new generalized model, namely the neutrosophic Pareto distribution (NPD), is developed in this article. The proposed model is a neutrosophic variant of the classical Pareto distribution, potentially useful for analyzing vague, unclear, indeterminate, or imprecise data. The structure form of the proposed distribution is skewed to the right and determined to be unimodal. Several characteristics of the NPD are investigated under the neutrosophic framework. The expressions for basic properties such as mean, variance, raw moments, and shape coefficients are obtained. The maximum likelihood approach is presented for estimating the imprecise distributional parameters of the proposed model. The extended notions of the NPD are explained with various key functions in the domain of applied statistical methods. Finally, the practical benefits of NPD are proven by analyzing two real datasets.
Unveiling the m6A Methylation Regulator Links between Prostate Cancer and Periodontitis by Transcriptomic Analysis
Authors: Ding Dexin , Liu Guobin , Gao Jianing , Cao Muyang
Published: September 2022

Objective. To identify the N6-methyladenosine (m6A) methylation regulator genes linking prostate adenocarcinoma (PRAD) and periodontitis (PD). Materials and Methods. PD and TCGA-PRAD GEO datasets were downloaded and analyzed through differential expression analysis to determine the differentially expressed genes (DEGs) deregulated in both conditions. Twenty-three m6A RNA methylation-related genes were downloaded in total. The m6A-related genes that overlapped between PRAD and PD were identified as crosstalk genes. Survival analysis was performed on these genes to determine their prognostic values in the overall survival outcomes of prostate cancer. The KEGG pathways were the most significantly enriched by m6A-related crosstalk genes. We also performed lasso regression analysis and univariate survival analysis to identify the most important m6A-related crosstalk genes, and a protein-protein interaction (PPI) network was built from these genes. Results. Twenty-three m6A methylation-related regulator genes were differentially expressed and deregulated in PRAD and PD. Among these, seven (i.e., ALKBH5, FMR1, IGFBP3, RBM15B, YTHDF1, YTHDF2, and ZC3H13) were identified as m6A-related cross-talk genes. Survival analysis showed that only the FMR1 gene was a prognostic indicator for PRAD. All other genes had no significant influence on the overall survival of patients with PRAD. Lasso regression analysis and univariate survival analysis identified four m6A-related cross-talk genes (i.e., ALKBH5, IGFBP3, RBM15B, and FMR1) that influenced risk levels. A PPI network was constructed from these genes, and 183 genes from this network were significantly enriched in pathogenic Escherichia coli infection, p53 signaling pathway, nucleocytoplasmic transport, and ubiquitin-mediated proteolysis. Conclusion. Seven m6A methylation-related genes (ALKBH5, FMR1, IGFBP3, RBM15B, YTHDF1, YTHDF2, and ZC3H13) were identified as cross-talk genes between prostate cancer and PD.
The Analysis of Feasibility of Sale of Public Sports Center in Korea
Authors: Shin Sang-Hyun , Jang Seung-Hwan
Published: September 2022

The purpose of this study is to analyze the feasibility of selling the public sports center and to verify the feasibility of selling the public sports center. We analyze the feasibility of the wholesale including management rights and the feasibility of the stake sale method to maintain management rights. Based on the financial data collected through the National Sports Promotion Corporation, we estimated the average cash flows of the Bundang and Ilsan Public Sports Centers by the year 2020 and the past five years (2016–2020). The present value is calculated through the cash flow, and the NPV (net present value) is used as the method. In conclusion, firstly, the wholesale (bidding) method is expected to lose some of the national treasury costs due to the difference between the appraisal value and the sale price. Although the public sports center has set options for sustainable operation, it is difficult to guarantee continued operation, and the program can be expected to be changed and increased. Because of this, it is difficult to maintain its function as a public sports center, and the loss of the national treasury is expected. As a result, the private sale (bidding) method is unlikely and is considered inappropriate. Secondly, in the case of stake disposal, it is unlikely that private investors will be able to sell their stakes considering the profitability and cash flow of the two centers, as stable profitability and dividend payout is an important criterion for private investors. Therefore, it is more realistic to sell to a structure that can fully reflect private business techniques through in‐kind investment, and it is desirable to pursue a share transfer or additional stake disposal after securing a certain portion of profitability through the issuance of convertible bonds.
LncRNA TP73-AS1 Exacerbates the Non-Small-Cell Lung Cancer (NSCLC) Process via Regulating miR-125a-3p-Mediated ACTN4
Authors: Tong Yueyang , Feng Zhemin , Li Yaqian , Yan Chenxi , He Wenbo , Chen Xueyuan
Published: September 2022

Background. LncRNA TP73-AS1 has been revealed to exert a noteworthy impact on the occurrence and advancement of different cancers. In this study, we explored the function of TP73-AS1 in tumor growth, cell progression as well as the relevant molecular mechanism in non-small-cell lung cancer (NSCLC). Methods. QRT-PCR was employed to assess the expression of TP73-AS1, miR‐125a-3p, and actinin alpha 4 (ACTN4) in NSCLC cells. The biological effect of TP73-AS1 on NSCLC cells was assessed by cell transfection, CCK8, and transwell experiments. We further predicted the interaction among RNAs (TP73-AS1, miR-125a-3p, and ACTN4) through bioinformatics online tools and verified via luciferase reporter, RNA immunoprecipitation, and qRT-PCR assays. Xenograft models of SPC-A1 cells were conducted to test how TP73-AS1 regulates tumorigenesis. Western blot, as well as the immunohistochemistry (IHC) assays, was utilized to measure the expression levels. Functions of TP73-AS1 in NSCLC progression through the miR-125a-3p/ACTN4 axis were investigated by rescue experiments. Results. Knockdown of TP73-AS1 suppressed the growth and simultaneously attenuated the migration and invasion ability of NSCLC SPC-A1 and A549 cells. Bioinformatics and molecular mechanism assays demonstrated that TP73-AS1 could bind to miR-125a-3p/ACTN4 and regulate their expression. Moreover, the rescued‐function experiment demonstrated that suppressing miR-125a-3p or elevating ACTN4 turned around the suppression effect of sh-TP73-AS1 on NSCLC progression. TP73-AS1 inhibition could also inhibit the NSCLC tumor growth and correspondingly regulated the expression of miR-125a-3p and ACTN4 in the tumor xenograft model. Conclusion. The present study indicated that TP73-AS1 affects NSCLC progression through a new competitive RNA (ceRNA) regulatory network of miR-125a-3p/ACTN4, providing an underlying target for NSCLC treatment in the future.
Correlation Analysis between Higher Education Level and College Students’ Public Mental Health Driven by AI
Authors: Cai Yinying , Tang Ling
Published: September 2022

Generally, there is a certain correlation between the level of higher education and the public mental health of college students. Traditionally, questionnaires and literature research methods are used to analyze the correlation between mental health and higher education, but these methods are always limited by many factors, such as resource conditions, survey paths, theoretical framework, and technical means. In recent years, with the rapid development and application of artificial intelligence technology, a new direction of analyzing the correlation between higher education level and college students’ public mental health has been given. The artificial intelligence method makes the correlation analysis change from subjective to big data algorithm evaluation, which can make up for the shortcomings and inefficiency of traditional methods, truly analyze the degree of correlation, and put forward exact solutions, which is of great significance for further evaluating and monitoring the public mental health of college students in higher education. This study first analyzes different AI algorithms and determines to use convolution neural network and random forest algorithm to establish an AI correlation model. After testing and data analysis, the established model has an accuracy of 87.5% in the determination and analysis of correlation. Compared with support vector machine (SVM) and backpropagation (BP) neural network algorithm, it has a higher recognition accuracy.
Tourism Route Selection Model for Tourism Sustainable Development Based on Improved Genetic Algorithm
Authors: Qi Jingwen , Wang Qiuhong
Published: September 2022

The improvement of people’s quality of life also promotes the development of tourism. The traditional travel mode is no longer suitable for the needs of modern people. How to quickly determine the optimal tourist route according to the needs of different families is the current sustainable development direction of tourism. Scientific planning of tourist routes to minimize the cost and time of tourists is very important for the improvement of tourism experience. This study employs an improved genetic algorithm (IGA) to find the best tourist route based on this requirement. With the increase of tourist attractions, routes, and demands, the traditional genetic algorithm (GA) has problems such as premature convergence and poor local search ability when planning the tourist route. The existence of these problems will affect the effect of route planning. IGA proposes three improvements to traditional GA. One is to introduce the ant colony algorithm (ACA) to initialize the parameters in the GA. This algorithm is introduced to alleviate the over-reliance of GA on initializing the population and the poor adaptability of individual populations. Second, because the crossover probability parameter in GA has such a large influence on the final solution, this study proposes an adaptive strategy for adjusting the crossover probability to improve population fitness. Third, considering the weak local search ability of GA and the problem of premature convergence, this study introduces the 2-opt optimization algorithm to improve the quality of the solution. The results of the experimental analysis confirm the effectiveness of the proposed method.
Infantile Hemangioma Treated with Propranolol Readmission Trends, Complications of Therapy, and Cost: A PHIS Database Study
Authors: Abu-Rmaileh Muhammad , Hairston Hayden C. , Zaniletti Isabella , Kompelli Anvesh , Davis Kyle P. , Gardner James Reed , Bolin Elijah H. , Richter Gresham T.
Published: September 2022

Objective. To examine admission trends, complications, and costs for inpatient infantile hemangioma (IH) associated with propranolol therapy utilizing the Pediatric Health Information System (PHIS) database. Study Design. A retrospective cohort study was completed using the PHIS database. The PHIS database was queried from 2008 to 2020 for children without cardiac disease and between the ages of three weeks and one year who were admitted with a diagnosis of IH and administered propranolol. Admissions were trended annually and by geographic region. Primary outcomes were length of stay (LOS), readmission, mortality, propranolol-related complications, and costs. Bivariate and multivariable analyses were employed to identify predictors of the primary outcomes. Results. A total of 2290 unique patient encounters were identified. Admissions steadily decreased after 2011, with variations by geographic region. There was no mortality and only 60 (2.6%) propranolol-related complications. African-American race (odds ratio (OR) 1.20 [95% CI: 1.02-1.41]), respiratory comorbidities (OR 2.04 [95% CI: 1.42-2.93]), neurologic conditions (OR 1.34 [95% CI: 1.09-1.59]), admission to an intensive care unit (OR 1.31 [95% CI: 1.09-1.59]), bronchospasm (OR 1.37 [95% CI: 1.22-1.55]), and hyperkalemia (OR 1.86 [95% CI: 1.08-3.20]) were associated with increased LOS. Neurologic conditions (OR 2.87 [95% CI: 1.76-4.67]) and respiratory comorbidities (OR 2.48 [CI: 1.43-4.30]) were associated with readmission. Average cost per admission was $5,158 ($3,259 to $8,560 range). Conclusion. There is an overall national decline in rate of admissions for IH propranolol therapy. Inpatient admission may be beneficial for patients with neurologic or respiratory conditions.
To Explore and Analyze the Safety and Clinical Efficacy of Periocline-Assisted Periodontal Basic Therapy on Chronic Periodontitis
Authors: Zhang Shengnan , Ye Hongyan , Sun Jing , Tong Dongdong , Meng Junru
Published: September 2022

Objective. This study aimed to investigate and analyse the clinical efficacy and safety of periocline-assisted periodontal foundation in the therapy of chronic periodontitis. Methods. From May 2018 to January 2021, 108 patients with chronic periodontitis were treated at our institution and randomly assigned equally to either the control or the experimental group. The plaque index (PLI), sulcus bleeding index (SBI), probing depth (PD), and periodontal attachment level (AI) were evaluated before and after periodontal basic therapy in the control group and periocline as an adjunct in the experimental group. Lactobacillus (LB) and Porphyromonas gingivalis (PG) concentrations in saliva were measured before and after therapy, and adverse responses during treatment were noted. Results. The levels of PLI, SBI, PD, and AI in the two groups were significantly lower in both groups at 1 and 3 months posttreatment compared to baseline; the levels of PLI and SBI were higher, and the levels of PD and AI were lower at 3 months after treatment compared to 1 month after treatment; compared with the control group at 1 month and 3 months after treatment, the levels of PLI, SBI, PD, and AI in the experimental group were lower than those in the control group (

P
<
0.05

). The LB level was higher and the PG level was lower in both groups compared to baseline at 1 and 3 months posttreatment. The LB level was higher and the PG level was lower at 3 months posttreatment compared to 1 month after treatment. Compared with the control group at 1 month and 3 months after treatment, the LB level was higher, and the PG level was lower in the experimental group (

P
<
0.05

). No significant adverse effects were observed in either group during the treatment period. Only 1 patient in the experimental group had mild gastrointestinal reactions, mainly nausea, without obvious neurological symptoms or abnormal blood changes, which did not affect the treatment. Conclusion. Periodontal fundamental therapy with perioclines may be a potential treatment for persistent periodontitis. It improves the primary clinical indicators, increases dysbacteriosis control, and has a strong safety profile. It could effectively control the development of clinical symptoms of periodontitis and reduce tissue destruction, with obvious clinical treatment effects. It could be used as the first choice for topical treatment of chronic periodontitis. It is recommended for further study by a wide range of researchers.
Integrated Use of Cattle Manure and NPS Fertilizer to Improve the Yield of Grain Amaranth (Amaranthus caudatus L.) in Southwest Ethiopia
Authors: Mekonnen Getachew
Published: September 2022

There is a need to optimize the modus operandi of fertilizer beneath farmers’ situations, mainly its application alongside organic resources. The study is aimed at investigating the effect of combined application of NPS blended fertilizer and cattle manure on growth, yield attributes, and yield of grain amaranth. The experiments were conducted in 2020 main cropping season in 3 localities, i.e., Guraferda, Menitgoldiya, and Menitshasha woredas in Southwest Ethiopia. The treatments were consisted of four NPS blended fertilizer levels (0, 20, 40, and 60 kg·ha−1) and four cattle manure series (0, 4, 8, and 12 t·ha−1). The experiment was laid out as a randomized complete block design (RCBD) in a factorial arrangement and was replicated 3 times. The effects revealed that the combined efficacy of NPS blended fertilizer and cattle manure significantly affected the days to flowering, days to physiological maturity, plant height, panicle length, number of panicles per plant, weight of thousand-grain, above-ground biomass yield, and grain yield. The highest amaranth grain yield of 1264.4 kg·ha−1 was recorded with 60 kg NPS fertilizer ha−1 and 12 t cattle manure ha−1 in combination followed by 60 kg NPS fertilizer ha−1 + 8 t cattle manure ha−1. The partial budget analysis indicated that the highest price 22759 ETB ha−1 was received from 60 kg·ha−1 NPS fertilizer and 12 t·ha−1 cattle manure. The results of this study indicated that application of 60 kg·NPS ha−1 in mixture with 12 t·ha−1 cattle manure is the best combination to achieve the maximum yield in the study areas. Therefore, in light of the significant response of amaranth to organic and inorganic fertilizer, further studies aimed at promoting integrated soil fertility management and formulation of fertilizer recommendation on yearly soil and plant test bases over locations will be useful.
A Hybrid Approach by CEEMDAN-Improved PSO-LSTM Model for Network Traffic Prediction
Authors: Shao Bilin , Song Dan , Bian Genqing , Zhao Yu
Published: September 2022

As an important part of data management, network traffic evaluation and prediction can not only find network anomalies but also judge the future trends of the network. To predict network traffic more accurately, a novel hybrid model, integrating Complete Ensemble Empirical Mode Decomposition with Adaptive Noise (CEEMDAN) with long short-term memory neural network (LSTM) optimized by the improved particle swarm optimization (IPSO) algorithm, is established for network traffic prediction. Firstly, an LSTM prediction model for the real-time mutation and dependence of network traffic is constructed, and the IPSO is applied to optimize the hyperparameters. Then, CEEMDAN is introduced to decompose sequences of raw network traffic data into several different modal components containing different information to reduce the complexity of the network traffic sequence. Finally, the evaluation of the experiments shows the feasibility and effectiveness of the proposed method by comparing it with other deep neural architectures and regression models. The results show that the proposed model CEEMDAN-IPSO-LSTM produced a significantly superior performance with a reduction of the prediction error.
SLC7A1 Overexpression Is Involved in Energy Metabolism Reprogramming to Induce Tumor Progression in Epithelial Ovarian Cancer and Is Associated with Immune-Infiltrating Cells
Authors: You Shijing , Zhu Xiaoying , Yang Yao , Du XiuZhen , Song Kejuan , Zheng Qingmei , Zeng Pengjiao , Yao Qin
Published: September 2022

Cationic amino acid transporters (SLC7A1/CAT1) are highly expressed in human ovarian cancer (OC) tissues. However, the specific biological functions and mechanisms involved remain unclear. We used bioinformatics analysis to explore SLC7A1 expression level, prognostic value, and tumor mutation burden (TMB) in ovarian cancer (OC) tissues. We performed in vitro experiments to identify the expression and biological function of SLC7A1 in epithelial ovarian cancer (EOC) tissues and cells. An amino acid autoanalyzer was used to detect the effect of SLC7A1 on amino acid metabolism in EOC cells. Finally, SLC7A1 in OC was evaluated for cell-to-cell signalling and immune infiltration using online databases. We found that increased SLC7A1 expression in EOC cells and tissues was associated with poorer survival outcomes (

P
<
0.05

) but not with tumor stage or grade of OC (

P
>
0.05

). SLC7A1 is involved in the transport of phenylalanine and arginine in EOC cells, and its knockdown reduced the proliferation and migration of EOC cells and the resistance of cells to cisplatin. Furthermore, the TIMER database indicated that SLC7A1 overexpression was significantly positively correlated with levels of CD4+ memory resting cells, CD8+ effector memory cells, M0 macrophages, and cancer-associated fibroblasts (CAFs) in OC (

P
<
0.05

) and significantly negatively correlated with CD4+ memory-activated cells (

P
<
0.05

). Cell immunofluorescence indicated that SLC7A1 overexpression may affect the distribution of immune-infiltrating lymphocytes in tumors by inhibiting the expression of CCL4. Therefore, we concluded that SLC7A1 is involved in the metabolic remodelling of amino acids in EOC to promote tumor development and cisplatin resistance and is related to the tumor-infiltrating immune microenvironment of OC. SLC7A1 is a biomarker for predicting EOC progression and cisplatin resistance and represents a promising target for EOC treatment.
Research on Monitoring of Gymnastics Facilities and Intelligent Optimal Distribution of Gymnastics Venues Based on Internet of Things
Authors: Liu Hongbo , Wang Yuzhen
Published: September 2022

In view of the low level of gymnastics facilities monitoring and intelligent management of gymnastics venues, which cannot effectively manage gymnastics venues in real time, this paper proposes a method of gymnastics facilities monitoring and intelligent optimization distribution of gymnastics venues in the Internet of Things. This paper will build an information monitoring model, introduce a particle swarm optimization algorithm to participate in the location layout, and explore the actual effect of gymnastics and the Internet of Things. The research results show that (1) the system can measure the mechanical error of facilities and ensure that the controllable fault tolerance rate is less than 1%. (2) The quality of system monitoring is evaluated in accuracy, time, delay, and satisfaction, and the results are basically satisfactory, but the accuracy and time still need to be improved. (3) Using the evaluation system of sports facilities to test the temperature, humidity, facility pressure, and energy consumption suitable for gymnastics and to verify the injury tendency of athletes. When the damage tendency is between 70% and 100%, the actual damage rate is 1. (4) The speed of the PSO algorithm is faster than other methods, which is used to optimize the layout of gymnastics venues and has a certain role in promoting the construction of gymnastics venues. The system model designed in this paper performs well in gymnastics and needs to be further improved and optimized.
Strong Total Monophonic Problems in Product Graphs, Networks, and Its Computational Complexity
Authors: Varghese Eddith Sarah , Xavier D. Antony , Alsinai Ammar , Mathew Deepa , Amirtha Raja S. Arul , Ahmed Hanan
Published: September 2022

Let G be a graph with vertex set as V(G) and edge set as E(G) which is simple as well as connected. The problem of strong total monophonic set is to find the set of vertices T⊆V(G), which contains no isolated vertices, and all the vertices in V(G)\T lie on a fixed unique chordless path between the pair of vertices in T. The cardinality of strong total monophonic set which is minimum is defined as strong total monophonic number, denoted by smt(G). We proved the NP‐completeness of strong total monophonic set for general graphs. The strong total monophonic number of certain graphs and networks is derived. If l, m, n are positive integers with 5 ≤ l ≤ m ≤ n and m ≤ 2l − 1, then we can construct a connected graph G with strong monophonic number l and strong total monophonic number m.
Creep Properties of Axially Compressed Fly Ash Concrete under Sulfate Corrosion
Authors: Cao Jian , Han Ziyang , Du Zhifeng
Published: September 2022

Creep, sulfate erosion resistance, fly ash content of concrete, and sustained compression load are important factors that will affect the long-term performance of concrete. It is of great interest to combine these effects together to make a comprehensive investigation of fly ash concrete. However, the concrete creep under both sustained compression load and sulfate attack conditions has rarely been reported. To obtain the creep characteristics of fly ash concrete in a sulfate environment, this paper first finishes the creep experiments of fly ash concrete under sustained compression load and sulfate attack. The test factors include the load stress level, the concentration of sulfate solution, and the content of fly ash. Based on the creep mechanism of fly ash concrete under sulfate erosion, the relationship between time-dependent section area variation and creep was carried out. After comparing different creep models, the creep calculation model of fly ash concrete under sulfate erosion was built via the B4 model combined with the cross-sectional area of the damaged layer and undamaged layer of concrete. Finally, comparing the calculated values with the test results, the calculated results were in good agreement with the test data, which is of practical significance to the practical engineering application and the improvement of structural reliability.
Chelerythrine Inhibits Stemness of Cancer Stem-Like Cells of Osteosarcoma and PI3K/AKT/mTOR Signal
Authors: Chen Zhixing , Yang Hui , Zhang Qianlu , Hu Qiongying , Zhao Ziyi
Published: September 2022

Chelerythrine (CHE) is widely found in many herbs and is the main alkaloid constituent of Toddalia asiatica (L.) LAM. It has been proved to exert remarkable antitumor, antifungal, anti-inflammatory, and antiparasitic effects. In osteosarcoma, CHE is reported to inhibit proliferation and promote apoptosis. However, the effect of CHE on cancer stem-like cells (CSCs), which contribute to metastasis and recurrence in osteosarcoma, is still largely unknown. In this study, we investigated the effects of CHE on the stemness and malignant behaviors of CSCs derived from osteosarcoma cells. CSCs were enriched by culturing in serum-free medium. The effects of CHE on stemness were measured by detecting stemness factors and sphere formation ability. The effects of CHE on chemosensitivity to doxorubicin and MTX were measured by Annexin V-FITC/PI double staining. The effects of CHE on CSC malignancy were measured by performing CCK-8, colony formation, tumor formation in soft agar, migration, and invasion assays. We first enriched CSCs from osteosarcoma cells, which were characterized by upregulated stemness markers, including Oct4, Nanog, and Nestin. The addition of CHE clearly decreased malignant behaviors, including colony formation, tumor formation in soft agar, migration, and invasion. CHE also inhibited stemness and thus induced the failure of sphere formation. Moreover, CHE promoted apoptosis induced by chemo agents, including doxorubicin (DOX) and methotrexate (MTX). After CHE treatment, the protein expression of MMP-2/9 was significantly decreased, potentially inhibiting invasion. CHE also exhibited an inhibitory effect on the phosphorylation of PI3K, AKT, and mTOR, which is an upstream regulatory signaling pathway of MMP-2/9. In summary, CSCs derived from U2OS and MG-63 cells, CHE could inhibit the stemness and malignant behaviors of CSCs potentially by inhibiting the PI3K/AKT/mTOR signaling pathway.
Optimal Design and Dynamic Performance Analysis of Vehicle Suspension Employing an Eccentric Inerter
Authors: Qiu Chengqun , Chen Ang , Xu Yuqiu , Shen Yujie
Published: September 2022

This paper concerns the dynamic performance analysis of the vehicle ISD (inerter-spring-damper) suspension employing an eccentric inerter. Firstly, the quarter car model of the two basic vehicle suspension layouts involving an eccentric inerter, namely, the series-connected layout and the parallel-connected layout, is established. Then, by considering the overall performance such as the vehicle body acceleration, the suspension working space, and the dynamic tire load, the key parameters of the two suspensions are optimized by using the genetic algorithm. Simulation analysis results indicate that the series-connected vehicle ISD suspension is superior to the parallel-connected one, and all of the RMS values of the body acceleration, the suspension working space, and the dynamic tire load are decreased significantly by comparing to the conventional suspension, while the improvement of the parallel-connected vehicle ISD suspension is relatively poor. At last, the impact of the flywheel eccentricity and the screw pitch on the dynamic performance indices of the two suspensions is discussed, and the trade-offs among the three performances are analyzed, which will provide a guide method for the suspension design when considering the eccentric factor.
Experimental Study on the Inhibition of RANKL-Induced Osteoclast Differentiation In Vitro by Metformin Hydrochloride
Authors: Chen Zhang , Zige Liu , Sai Kiang Yeow , Desheng Chen
Published: September 2022

Objective. Establishment of an in vitro osteoclast induction model under nuclear factor-κB receptor activator ligand (RANKL) induction for investigating the effect of metformin hydrochloride (Met) on osteoclast differentiation. Methods. RANKL induced the differentiation of mouse bone marrow macrophages (BMMs) into osteoclasts in vitro, and Met was added at different concentrations for intervention during the induction process. After 5 d of culture and fixation, the number of osteoclasts was counted by tartrate-resistant acid phosphatase (TRAP) staining and F-actin staining, and the function of osteoclasts was examined with hydroxyapatite-coated plates. Real-time fluorescence quantitative PCR was performed to detect the expression of Cathepsin K, osteoclast associated receptor (OSCAR), and TRAP, and the effect of Met on Mitogen-activated protein kinases (MAPK) signaling pathway was detected by Western blot. Results. Met significantly reduced osteoclast formation, F-actin ring formation, bone resorption, and the expression of relevant genes Cathepsin K, OSCAR, and TRAP. The Western blotting study demonstrated that Met inhibited the MAPK signaling pathway by decreasing the phosphorylation of extracellular regulated protein kinase (ERK), which plays important roles in osteoclast formation. Conclusion. Metformin hydrochloride inhibited the differentiation of osteoclasts, decreased the bone resorption area, and suppressed phosphorylation of ERK in vitro.
On Pata Convex-Type Contractive Mappings
Authors: Aktay Merve , Özdemir Murat
Published: September 2022

In this work, we introduce weak Pata convex contractions and weak

E

-Pata convex contractions via simulation functions in metric spaces to prove some fixed point results for such mappings. Also, we consider an example related to weak Pata convex contractions. Consequently, our results generalize and unify some results in the literature.
Digital Transformation and Financial Risk Prediction of Listed Companies
Authors: Xinxian Chen , Jianhui Cai
Published: September 2022

Digitalization is a revolution, a frontal battleground in the new global competitive landscape, and a long-distance race for which all employees must be prepared, and organizations must actively embrace the resulting changes. The article begins by analyzing three characteristics of digital transformation and enterprise growth: the heterogeneity of digital transformation’s impact on enterprise growth and the process by which digital transformation influences enterprise growth. In addition, this article develops a convolutional neural network-based financial early warning model to aid businesses’ digital transformation initiatives.
Stellate Nonhereditary Idiopathic Foveomacular Retinoschisis: Cataract Surgery
Authors: Van der Auwera Sofie , Kallay Oscar
Published: September 2022

Purpose. We present the first case described in the literature of cataract surgery in a patient with stellate nonhereditary idiopathic foveomacular retinoschisis (SNIF). Methods. In this case report, we describe the extensive workup we did on our patient, including optical coherence tomography, fundus autofluorescence, fluo-angiography, full field electroretinogram, and genetic testing. We moreover describe the cataract surgery with clear lens extraction and implanting of a multifocal implant. Results. The refractive and lifestyle profile of our patient made implantation of multifocal intraocular implants the only solution for this case. During preoperative measurements, a SNIF diagnosis was suspected after optic coherence tomography imaging which led to an even more extensive workup of our patient and the diagnosis of stellate nonhereditary idiopathic foveomacular retinoschisis. We then proceeded to cataract surgery, which was performed safely and without any sequellae. Conclusion. Stellate nonhereditary idiopathic foveomacular retinoschisis (SNIF) is a relatively new disease entity. Only few cases in the literature describe this disease, and none of them describe cataract surgery in a patient with SNIF. We therefore describe the first known cataract surgery in such a case. Long term follow-up results show that the procedure can be performed safely. Summary Statement. We hereby present the first case described in the literature of cataract surgery of a patient diagnosed with stellate nonhereditary idiopathic foveomacular retinoschisis. A clear lens extraction with implantation of a multifocal intraocular implant was conducted with excellent postoperative results and a happy patient.
Predictors of Mortality in Adults with Acute Kidney Injury Requiring Dialysis: A Cohort Analysis
Authors: Kahindo Charles Kangitsi , Mukuku Olivier , Mokoli Vieux Momeme , Sumaili Ernest Kiswaya , Wembonyama Stanis Okitotsho , Tsongo Zacharie Kibendelwa
Published: September 2022

Introduction. Acute kidney injury (AKI) requiring renal replacement therapy is accompanied by considerable mortality. This present study evaluated predictors of mortality at initiation of hemodialysis (HD) in AKI patients in Goma (in the Democratic Republic of the Congo (DRC)). Methods. A single-centre cohort survey evaluated the clinical profile and survival rates of AKI patients admitted to HD in the only HD centre in Goma, North Kivu province (DRC). Data were collected from patients who underwent HD for AKI. Patient demographics, comorbidities, clinical presentation, laboratory tests, and mortality were reviewed and analyzed. The survival study used the Kaplan–Meier curve. Predictors of mortality were evaluated using Cox regression. Results. Of the 131 eligible patients, the mean age was 43.69 ± 16.56 years (range: 18–90 years). Men represented 54.96% of the cohort. The overall HD mortality rate was 25.19% (n = 33). In multivariate analysis, independent predictors of mortality in AKI stage 3 patients admitted to HD were as follows: age ≥ 60 years (adjusted hazard ratio (AHR) = 15.89; 95% CI: 3.98–63.40;p<0.0001), traditional herbal medicine intake (AHR = 5.10; 95% CI: 2.10–12.38;p<0.0001), HIV infection (AHR = 5.55; 95% CI: 1.48–20.73;p=0.011), anemia (AHR = 9.57; 95% CI: 2.08–43.87;p=0.004), hyperkalemia (AHR = 6.23; 95% CI: 1.26–30.72;p=0.025), respiratory distress (AHR = 4.66; 95% CI: 2.07–10.50;p<0.0001), and coma (AHR = 11.39; 95% CI: 3.51–36.89;p<0.0001). Conclusion. Initiation of hemodialysis with AKI has improved survival in patients with different complications.
Design and Analysis of a New Coupled Inductor-Based Interleaved High Step-Up DC-DC Converter for Renewable Energy Applications
Authors: Hashemzadeh Seyed Majid , Babaei Ebrahim , Hosseini Seyed Hossein , Sabahi Mehran
Published: September 2022

In this paper, a novel nonisolated interleaved high step-up DC-DC converter is proposed based on the coupled inductor and voltage multiplier cell (VMC) methods. Due to the interleaved structure, its input current ripple is low. The low input current ripple and also high power efficiency make the proposed converter suitable for renewable energy applications like photovoltaic (PV) and fuel cell (FC) power generation systems. The windings of the coupled inductors are combined with VMCs to further increase the output voltage with a low power switch’s duty cycle. This combination also leads to obtaining a flexible voltage gain that can be adjusted by coupled inductors’ turns ratio and power switches’ duty cycle. The voltage peaks over semiconductors are much lower than the output voltage. Therefore, low-rated semiconductors can be used for the implementation of the proposed converter, which can reduce the cost and volume. Generally, high voltage gain, low voltage, current stress of power switches, low input current ripple, high efficiency, common ground between the input and output ports, and a low number of elements are the main benefits of the suggested structure. The operation principle, steady-state analysis, and comparison with other converters are presented to show the advantages of the suggested converter. Also, a prototype is built, and the experimental results are presented to prove the theoretical analysis. This prototype is implemented with 200 W rated power, 25 V∼400 V voltage conversion, and 50 kHz switching frequency. Additionally, the efficiency is measured at 95.3% at the rated power.
Hesitancy toward Childhood Vaccinations: Preliminary Results from an Albanian Nursing Staff’s Investigation
Authors: Gjini Enkeleda , Carestia Mariachiara , Cenko Fabian , Di Giovanni Daniele , Mehmeti Irsida , Moramarco Stefania , Yulli Alban , Buonomo Ersilia
Published: September 2022

Healthcare professionals are important models for their patients since their individual knowledge and attitudes toward vaccination can influence the patient’s willingness to adhere to vaccination campaigns. After developing a structured questionnaire, it was administered to a sample of nursing staff working in public vaccination centers in Albania (December 2020-January 2021), in order to conduct a preliminary investigation aimed at describing knowledge, attitudes, beliefs, and hesitancy toward childhood vaccinations. Among the sample of nurses involved in the administration of vaccines (n.64, 92% females), most of them were confident about vaccines and favorable to childhood vaccinations (90%). However, when specifically investigating beliefs, nearly a quarter of the sample showed to be hesitant; 22% were unsure or partially agreed that vaccines might cause conditions such as autism and multiple sclerosis. A high risk of hesitancy was identified in the youngest staff especially when their work experience was below 10 years or when they graduated less than 10 years before (OR: 5.3, CI: 1.4–19.5; and OR: 4.2 CI: 1.2–14.6). Similarly, a low acceptance rate (54%) was detected for future childhood SARS-CoV-2 vaccines among the nurses, which is a sign of high levels of vaccine hesitancy. With regard to knowledge about childhood vaccine contraindications, none of the nurses identified all the ten correct answers, while only 13% answered at least six questions correctly. These preliminary results highlight the need of investigating more Albanian nursing staff’s knowledge and attitudes toward child vaccinations, therefore investing in tailored training. Due to the ongoing Covid-19 pandemic and the roll-out of mass vaccination, the role of healthcare workers remains crucial and needs more support to manage the changing public opinion as well as quickly evolving vaccine technologies.
Evaluation of Phytochemical Content and the Antioxidant and Antiproliferative Potentials of Leaf Layers of Cabbage Subjected to Hot Air and Freeze-Drying
Authors: Cuong Do Manh , Kim Hee Young , Keshawa Ediriweera Meran , Cho Somi Kim
Published: September 2022

Cabbage (Brassica oleracea var. capitata f. alba), a cruciferous vegetable, is one of the most widely consumed vegetables worldwide. However, research on whether there are differences in its contents of phytochemicals and biological activities according to the drying method for each portion of the vegetable remains insufficient. The present study investigated the contents of representative polyphenols and isothiocyanates, the antioxidant capacity, and the antiproliferative effects among six leaf layers of cabbage subjected to hot air and freeze-drying. High-performance liquid chromatography analysis showed that most phenolic and flavonoid bioactive compounds were significantly accumulated in the outer cabbage leaf layer (P1), whereas isothiocyanates were most abundant in the leaf layer close to the core of the head (P5). The contents of isothiocyanates, gallic acid, epicatechin, p-coumaric acid, sinapic acid, and myricetin were significantly higher in the hot air-dried sample than in the freeze-dried sample, whereas the contents of catechin hydrate, chlorogenic acid, 4-hydroxybenzoic acid, and rutin hydrate were significantly higher in the freeze-dried sample. Compared to other leaf layers, P1 exhibited high antiproliferative efficacy against pancreatic, breast, and gastric cancer cells. P1 also showed excellent DPPH·(EC 50–4.208 ± 0.033 and 4.611 ± 0.053 mg/mL for hot air and freeze-dried samples, respectively) and ABTS· (2.422 ± 0.068 and 2.224 ± 0.070 mg/mL for hot air and freeze-dried samples, respectively) radical-scavenging effects. These results indicate that the contents of polyphenols and isothiocyanates in cabbage may vary depending on the leaf layer and the drying method. Our findings provide insight for applying appropriate food drying methods that can be used to produce cabbage leaf-based products with enhanced bioactivity.
[Retracted] Analysis of Graphic Design Based on AI Interaction Technology
Authors: Du Yishu , Xu Dong
Published: September 2022

The naive Bayes classification algorithm is used to determine the plane feature vector, and the color image enhancement algorithm based on the visual characteristics is used to improve the local contrast of the plane visual image. In addition, based on the visual perception intensity of each region of the interactive interface and the importance of visual perception elements in the edge contour, a hierarchical optimization model of graphical HMI is established, which is solved by the genetic algorithm. Finally, it has been proved that this system has high efficiency in image color processing, and the image enhancement effect is better, which meets the requirements of human visual perception. The contribution of this study lies in the design of the human‐computer interface plane visual image color enhancement system, so as to improve the visual effect of plane visual image color.
Classroom Simulation System of Oral English Teaching Based on a Network Computer
Authors: Song Yuchen , Wei Yi
Published: September 2022

The aim is to study the classroom simulation system of oral English teaching based on a network computer. A classroom simulation system for oral English teaching is proposed. Firstly, the third-party software “Baidu voice” recognition system is introduced into the oral training module of the system, which introduces the field of Baidu artificial intelligence into the system. Baidu AI open platform provides permanent and free speech technology services, including speech recognition, semantic analysis, speech synthesis, and other functions. Then, from the perspective of modern educational technology students, this paper attempts to design an artificial intelligence system module for middle school English teaching and explore the specific implementation conditions and ideas of the system. Finally, the students in a middle school are divided, including 37 in the top class and 34 in the normal class. The simulation results show that the system not only studies the listening and speaking materials but also deeply analyzes the data tables. The functions of English listening, speaking, homework release, and query are realized.
Analytical Investigation of Nonlinear Fractional Harry Dym and Rosenau-Hyman Equation via a Novel Transform
Authors: Alshammari Saleh , Iqbal Naveed , Yar Mohammad
Published: September 2022

We use a new integral transform approach to solve the fractional Harry Dym equation and fractional Rosenau-Hyman equation in this work. The Elzaki transform and the integral transformation are combined in the suggested method (ET). To handle two nonlinear problems, we first construct the Elzaki transforms of the Caputo fractional derivative (CFD) and Atangana-Baleanu fractional derivative (ABFD). The ultimate purpose of this study is to find an error analysis that demonstrates that our final result converges to the exact and approximate result. The convergent series form solution demonstrates the method’s efficiency in resolving several types of fractional differential equations. Furthermore, the solutions obtained in this study agree well with the exact solutions; thus, this strategy is powerful and efficient as an alternate way for obtaining approximate solutions to both linear and nonlinear fractional differential equations.
Association of Obstructive Sleep Apnea Syndrome (OSA/OSAHS) with Coronary Atherosclerosis Risk: Systematic Review and Meta-Analysis
Authors: Chen Liwen , Zou Shujing , Wang Jinhong
Published: September 2022

Objective. Obstructive sleep apnea syndrome (OSA) is the most common type of sleep disorders. This study aimed to systematically review the correlation between OSA and the risk of coronary atherosclerosis. Methods. Literature on case-control studies on the relationship between coronary heart disease (CHD) and sleep apnea syndrome was collected and collated, and the incidence of SAS in CHD and non-CHD patients was observed and compared. RevMan 5.2 analysis software and Stata12SE analysis software were used for heterogeneity test and combination analysis of the included studies. The results were expressed with odds ratio (OR), 95% confidence intervals (CI) were calculated, and publication bias and sensitivity tests were evaluated. Results. There was a statistical difference in OSA associated with the risk of coronary atherosclerosis between the experimental group and the control group [

OR
=
1.38

, 95% CI (1.18, 1.62),

P
<
0.0001

,

I

2

=
0
%

,

Z
=
3.93

]. OSA associated with vascular endothelial injury [

OR
=
3.59

, 95% CI (3.00, 4.29),

P
<
0.00001

,

I

2

=
90
%

,

Z
=
14.09

]. OSA is associated with vascular oxidation emergency [

OR
=
2.19

, 95% CI (2.05, 2.33),

P
<
0.00001

,

I

2

=
94
%

,

Z
=
23.40

]; OSA is associated with chronic vascular inflammation [

OR
=
1.70

, 95% CI (1.39, 2.07),

P
<
0.00001

,

I

2

=
16
%

,

Z
=
5.18

]. Conclusion. The incidence of obstructive sleep apnea in patients with CHD was higher than that in non-CHD patients, and obstructive sleep apnea was a risk factor for CHD.