bluuebunny/crossref_metadata_2025 huggingface dataset:
Desarrollo de la criticidad de la música en estudiantes de educación superior: revisión sistemática
Authors: Sigüeñas Carmen , Sigüeñas Ana , Huayta Yolanda
Published: March 2024

El presente artículo tiene como objetivo analizar los aportes científicos ligados al desarrollo de la criticidad de la música en estudiantes de educación superior, de países iberoamericanos, desde los años 2006 al 2021. El método utilizado fue una revisión sistemática con nivel descriptivo, empleando los criterios de cribado y elegibilidad a través de la guía de la Declaración PRISMA. La búsqueda se realizó en bases de datos online de SciELO, Scopus, EBSCO y ProQuest, aplicando los descriptores: "critical thinking", "criticality", "music", "music education", a su vez combinando entre ellos el uso de los booleanos AND y por último OR, en inglés y español. En la revisión del análisis se tuvo en cuenta las estrategias didácticas, secuencias metodológicas de incremento formativo, habilidades de pensamiento, autorregulación y motivación. Los resultados fueron el análisis de 22 artículos originales, de los cuales 3 fueron artículos con diseño no experimentales descriptivos, 4 cuasi experimentales, 1 no experimental observacional, 2 no experimentales correlacionales, 1 cuantitativo longitudinal, 3 investigación-acción, 4 fenomenológico hermenéutico, 1 cualitativo descriptivo, 1 teórico cultural y 3 de diseño mixto; resaltando la necesidad del acceso a nuevas formas de pensamiento crítico. Se concluyó que el desarrollo de la criticidad en la música requiere de una enseñanza auténtica, basada en el manejo de herramientas vanguardistas, estrategias pedagógicas innovadoras y actualizadas que generen la autonomía, la autorregulación y la motivación en el estudiante.
Reflections and perspectives on adjuvant treatment in the setting of resected hepatocellular carcinoma
Authors: Donadon Matteo , Di Martino Marcello , Baroffio Paolo , Polidoro Michela Anna
Published: March 2024

Hepatectomy is a curative procedure in selected patients affected by hepatocellular carcinoma (HCC). However, recurrence rates are as high as 70% five years after resection, and having a valid postoperative systemic regimen would represent a significant improvement in the care of HCC patients. While burgeoning evidence is emerging around the use of immunotherapy in the setting of resected HCC, little is yet known to allow the widespread use of immunotherapy after surgery. Here, we pointed out some reflections and perspectives on adjuvant strategies for patients with resected HCC and discussed potential benefits and drawbacks.
Improved Brain Function with Deep Spectrum Biotherapeutics
Authors: Strickland Iain , Oakley David S , Parievsky Anna
Published: March 2024

In this case series, we examine the impact of the Titan-iR Pro® deep spectrum biotherapeutic device on brain function in healthy individuals. Here we present 15 participants, aged 26-68 years, who enrolled in this open-label study, designed to assess the effect of a single 15-minute course of deep spectrum biotherapy on brain function. Although symptom-free upon enrollment, participants had diverse medical histories with some displaying early signs of cognitive decline. As part of the evaluation, all participants engaged in electroencephalogram (EEG) recording sessions that focused on assessing event-related potential (ERP) evaluations, including audio P300 amplitudes and latencies (speeds), neurocognitive testing, and physical reaction times. Following the Titan-iR Pro intervention an improvement in EEG-based cognitive markers was observed. These results underscore the importance of further investigation into the potential of advanced and deep spectrum photobiomodulation in the prevention and treatment of cognitive decline and other neurological disorders.
Comorbidies of Blood Pressure and Blood Glucose: Challenges and Future Trends
Authors: G R Ashisha , Mary X Anitha , C Karthik , Gheisari Mehdi
Published: March 2024

Background: Several kinds of research say that adjuvant blood glucose and blood pressure are usual, but an efficient solution for medical application count remains. This review analyzes the pandemic blood pressure and blood glucose to identify the publications which tell about the clinical practices and research gaps in systematic research.Methods: A study guides to identify the research of Blood Pressure (BP) and Blood Glucose. In order to analyze the recent innovations and research on BP and Blood glucose, the relevant publications and literature from journals were identified.Results: Co-morbidity of BP and Blood glucose is reported as very high. The commonness of blood pressure is thrice as high in type I diabetes patients and almost two times higher in type II diabetes patients when compared to others without Diabetes. The pervasiveness of getting depression is more in the female when compared with men. A detailed study about the linkage of BP and blood glucose tells that the relationship between them is not exactly clear.Limitations: Nearly all reviews providing the linkage of BP and blood glucose are with some limitations and they are not providing any clear conclusion.Conclusions: Present research tells that people having high blood glucose will have a greater chance of getting high blood pressure. More research is needed to state the linkage between BP, blood glucose, and the growth of diabetes mellitus issues and to provide support for managing Diabetes.
Metamaterial Labyrinth Wall Low-Frequency Sound Absorption Measurements for Restaurant Room Acoustics and Decorative Applications
Authors: Bader Rolf , Mischo Johannes , Gernert Stefanie , Mischo Hendrik
Published: March 2024

A labyrinth metamaterial wall with glass coverage is measured in a reverberating chamber and after its installation in a restaurant. Glass is used to meet two aims, namely acoustic absorption and visual design demands. The wall consists of five multiple labyrinth elements of 1.83 m$^2$ each. Glass was taken to make the wall act as a room lightning device where a translucent cover material is needed. Absorption measurements show about four times improved absorption compared to typical glass. Due to the metamaterial behavior, absorption is high in the low-frequency range below 300 Hz where damping is problematic with traditional materials. Especially in this range, the glass metamaterial wall is an excellent compromise between room acoustic and visual design demands, as loud low-frequencies make visitors speak louder and experience less intimacy with additionally reduced speech intelligibility. For mid-frequencies, absorption is shown less effective and improvements are discussed.
Empowering Future Teachers: The Role of Student Organizations in Enhancing Public Speaking and Teaching Skills
Authors: Alfi Zahra , Amalia Nur
Published: March 2024

Recognizing the pivotal role of teachers in shaping education, extensive research has been conducted to assess their effectiveness. Among the prominent challenges faced by many educators is mastering public speaking, a crucial skill for effective classroom instruction. This study delves into whether participation in student groups can augment aspiring elementary school teachers' public speaking and teaching competencies while emphasizing the significance of public speaking skills within the teaching profession. Employing descriptive qualitative methods such as interviews, observations, and document analysis, the research elucidates the profound impact of public speaking proficiency on teaching effectiveness. The study encompasses four key stages: preparation, implementation, analysis, and reporting. Twelve students participated as respondents, focusing on those actively engaged in group activities. Additionally, six lecturers from the Primary School Teacher Education Study Program, Muhammadiyah University of Surakarta, knowledgeable about the fundamental skill requirements for aspiring teachers and the program director, served as supplementary subjects. The findings suggest that engagement in student groups can significantly enhance aspiring teachers' public speaking skills, thereby better equipping them for successful careers in education.
Enhancing Mathematical Disposition in Geometry Instruction : The Role of E-Comics in Realistic Mathematics Education
Authors: Nugraha Trisna , Samsudin Asep
Published: March 2024

Success in learning mathematics can be measured through five aspects called the five strands of mathematical proficiency. These five aspects need to be taught fairly, resulting in a change in students' mathematical attitudes where this aspect is still minimally looked at and researched. Therefore, the research aims to analyze changes in students' mathematical dispositions by reviewing the role of e-comics in Realistic Mathematics Education (RME). This context-based mathematics learning approach is assumed to provide meaningful learning for students. This mixed-methods research with a sequential explanatory research design was carried out on 30 elementary school students by combining quantitative data collection and analysis techniques with qualitative data support. The research showed that using e-comics in RME learning significantly improved students' mathematical dispositions with a large effect size (Cohen’s effect size = 0,98). In a qualitative review involving data triangulation, evidence was found that using e-comics in RME learning has a role in facilitating the development of each student indicator, as evidenced in the high students’ enthusiasm or response in learning both in observations, questionnaires, and documentation studies. In this way, it is hoped that this innovation can be researched and developed further on a more diverse scale and content. In addition, this research provides further opportunities for research and teacher training related to developing RME learning designs and e-comics in learning.
Exploring Listening Relationship Pattern of Information Approval Process in Science Learning: A Qualitative Investigation Using TBLA (Transcript Based Lesson Analysis)
Authors: Hajar Maya Umi , Putra Dedy Dwi
Published: March 2024

This study reveals listening relationship patterns in the information approval process used to improve the quality of learning dialogue, especially in science learning. A qualitative method with a case study approach was used to analyze listening relationship patterns in science learning during one semester. A total of 3 science teachers, 31 students, and two academics involved in lesson study for learning communities were selected to capture a mutual listening relationship pattern in receiving information with a natural performance and not tense when observing. Observation, documentation, and clinical interviews were used as data collection techniques. Video and audio recorders were involved as documentation tools for this study. Transcript-based lesson analysis (TBLA) was included in conducting data analysis. The listening relationship patterns analysis results in classical discussion sessions in cycles 1–3, which tend to have semi-equal listening relationship patterns. Meanwhile, the listening relationship pattern in group discussion sessions in cycles 1 to 3 tends to be the isolated listening relationship group pattern. The shift in the pattern of listening relationships in group discussion sessions is caused by several factors, including student collaboration awareness, heterogeneous composition of students, tasks, and questions that challenge students, and appropriate interruptions of teacher direction. The research results provide a reference for reflection on developing teacher professionalism to improve more effective and meaningful learning.
Resiliencia empresarial y COVID. Un estudio local para el estado de Chihuahua, México
Authors: Martínez Morales Javier , González Milán David de Jesús
Published: March 2024

La resiliencia empresarial se define como la capacidad de las organizaciones para hacer frente a condiciones adversas o de incertidumbre, siendo capaces de crear soluciones distintas a problemas existentes, donde la generación de cambios deriva de los procesos de innovación propios de los individuos que la conforman, siendo este factor clave en la transformación y flexibilización de la organización. La crisis económica derivada de la contingencia sanitaria por COVID-19 ha resultado un reto para las empresas. Este trabajo indaga sobre los determinantes de la resiliencia empresarial en micro y pequeñas empresas de Hidalgo del Parral, Chihuahua (México). Se evidencía algunos determinantes de resiliencia empresarial, mostrando elementos que caracterizan una probabilidad alta, media, baja o nula resiliencia, identificando elementos clave relacionados con la continuidad empresarial, o la antigüedad de la misma.
Production Process of Premium Processed Fish in the Form of Tofu (Fish Tofu) at PT. Indo Lautan Makmur Sidoarjo Regency, East Java
Authors: Elshiva Danya Mozza , Azara Rima , Laksana Cakra
Published: March 2024

This Field Work Practice (PKL) aims to find out the production process, especially processed fish tofu at PT. Indo Lautan Makmur. PKL was carried out on September 1, 2023 to September 30, 2023 at PT. Indo Lautan Makmur Sidoarjo Regency, East Java. The methods used in this field work practice are observation, interviews, field practice, dan literature study. PT. Indo Lautan Makmur is a food company that produces processed products from sea fish. The production process of processed fish tofu uses the main raw material surimi mixed with other supporting ingredients such as liquid ISP, tapioca folur, palm oil, ice water, flavouring, sugar, pepper, salt, white butter, and STTP. The sequence of production of processed fish tofu starts with the preparation of surimi, followed by the process of kneading, molding, boiling I, boiling II, cooling I, cutting, frying, cooling II, freezing, packaging, and then storing. The practical results show that process of processed fish tofu is in accordance with Good Manufacturing Practice (GMP) standards
Analysis of the Causes of Turbine Power Efficiency Decreases
Authors: Kurniawan Ricky , Akbar Ali
Published: March 2024

Abstract. The steam turbine as the prime mover converts steam energy into kinetic energy and kinetic energy is further converted into mechanical energy in the form of rotation of the shaft turbine. Turbines as generator drives so as to produce electric power that can be used in various industrial fields. The energy required is large and the continuous use of the turbine must operate with sufficient stability for a long time. Turbine efficiency will decrease due to several factors such as errors during operation and duration of maintenance. Based on data obtained from PT. Synergy of Gula Nusantara PG. Kremboong turbine power efficiency will decrease because there are several factors that cause corrosion, erosion and wear and tear on turbine engine components. Steam for turbine drive produced by steam boilers containing dirt or inappropriate water ph can cause scale on the turbine so that the turbine cannot rotate optimally.
Use Of The Yamaha F100B Outboard Engine As a Populsion On The Rinca and Bawean Survey Boats
Authors: Aldiantofas Rizky Dwi , Akbar Ali
Published: March 2024

The aim of this research is to determine the use of the Yamaha F100B outboard engine as a propulsion for the Rinca and Bawean survey boats. The research was carried out within one month, namely August to September 2023. This research was carried out using practical field work methods. The variables in this research were the specification,work process, fuel efficiency system,  superiority, and environmental impact. The method in this research uses the observation method, namely the method of collecting data by recording directly while in the field. The research results show that the use of a Yamaha F100B outboard motor as a propulsion is able to provide adequate thrust for the survey vessel, with efficient fuel consumption. In the context of survey vessels, the reliability and speed of these motors are important factors in supporting successful marine survey operations.
Balancing climate resilience and adaptation for Caribbean Small Island Developing States (SIDS) : building institutional capacity
Authors: Galaitsi Stephanie , Corbin Christopher , Cox Shelly-Ann , Joseph Genora , McConney Patrick , Cashman Adrian , Springer Cletus , Keenan Jesse , Cummings Christopher , Trump Benjamin , Linkov Igor
Published: March 2024

Although the Caribbean's Small Island Developing States (SIDS) minimally contribute to global greenhouse gas emissions, they face disproportionate climate risks and are particularly susceptible to systemic economic threats posed by climate change and subsequent increases in climate variability. Historically, strategic programs and investments have sought to develop more robust and adaptive engineered systems to absorb climate threats. However, such initiatives are limited and under-resourced in the SIDS’ context. This article reviews existing climate strategies in the Caribbean and then critically examines current gaps and barriers relating to climate impact knowledge, needs, and implementation. This examination can assist Caribbean SIDS leadership to identify opportunities to transition from a vulnerability-reducing mindset to one of resilience and transformative adaptation to improve long-term economic outlooks, social welfare, and environmental stewardship despite recurring and escalating climate risks.
Hazardous and solid waste management planning in select African countries
Authors: Wilson Emily , Davidson Susannah , McDermott Andrew , Urban Angela
Published: March 2024

Managing wastes produced during contingency operations in United States Africa Command (USAFRICOM) locations has historically relied on local contract disposal or open-air burn pits, which have been shown to be harmful to the health of service members. Posture locations that can find alternative ways to manage waste, specifically through contracts with the host country’s waste services, can better protect the health and safety of the warfighter and the native landscapes. African waste systems are complex, decentralized systems with considerable regional variation. The lack of government-funded waste management services leaves many residents with few options for safe disposal. The differing waste disposal strategies are described to offer guidance for military operations in the focus countries of Gabon, Ghana, Kenya, Morocco, Niger, Senegal, and Uganda. Relevant international agreements regulating the flow of hazardous waste across borders that can impact disposal plans are also noted. This report serves as a reference to develop waste management alternatives in the USAFRICOM area of responsibility (AOR). Official Department of Defense and Army regulations should be consulted when devising an integrated waste management plan.
TRIM37 maintains 5hmC levels and stemness through preventing DNMT1 alternative splicing
Authors: HUNG SHIH-CHIEH , Ho Chun-Te , Li Ling-Hui , Chang Wei-Chao , Wu Heng-Hsiung , Chen Ya-Huey
Published: March 2024

The significance of DNA hydroxymethylation in stemness remains unknown. Here, we demonstrate 5hmC levels positively regulate mesenchymal stem cell (MSC) properties. Mechanistically, PARP1 recruits TET1 to hydrolyze methylated nucleotides on DNMT1 exons, helping CTCF to bind to exons and prevent DNMT1 alternative splicing in early MSCs. Furthermore, ATM phosphorylates TRIM37 at Th203 and promotes its entry into the nucleus, as well as the monoubiquitination of PARP1, thereby stabilizing the PARP1 protein. CTCF or TRIM37 knockdown induces replicative senescence of MSCs with loss of full-length DNMT1, while simultaneous treatment of MSCs during expansion with ATM activators, such as resveratrol, and TET1 activator, vitamin C, induces the rejuvenation of late MSCs through the TRIM37/PARP1/DNMT1 pathway. Through gene knockout, TRIM37 and PARP1 are shown to be involved in MSC aging and bone repair in vivo. This study highlights the role of DNA hydroxymethylation and its regulators in stemness, offering strategies for therapeutic interventions.
Overview of Interference Management in Massive Multiple- Input Multiple-Output Systems for 5G Networks
Authors: Aikoun Yves Fidèle , Yin Sheng
Published: March 2024

New challenges have arisen in the field of wireless communication systems since the advent of Fifth Generation (5G) networks and the main objectives of delivering higher data rates, ultra-low latency, more reliability, and massive network capacity. While massive multiple-input multiple-output (MIMO) systems have emerged as a key technology for delivering a more uniform user experience to multiple users simultaneously, the deployment of multiple radiated elements in a confined area can lead to interference between the transmitted and received signals, resulting in the degradation of system efficiency. Therefore, interference management techniques are essential to mitigate this impact and enhance system performance. This review aims to explore interference management techniques in massive MIMO systems, including beamforming methods, non-orthogonal multiple access (NOMA), and joint transmission coordinated multi-point (JT-CoMP). The objective is to analyze the performance of these techniques in terms of the network capacity, coverage, and reliability and to compare their effectiveness in reducing interference. The valuable insights gained from this investigation will serve to inform the design and optimization of these systems.
WITHDRAWN: Outdoor UDA Depth Estimation with Intra-domain Attention and Cross-domain Edge Constraint
Authors: Peng Guo , Pan Shuguo , Hu Peng , Pei Ling , Yu Baoguo
Published: March 2024

The full text of this preprint has been withdrawn by the authors due to author disagreement with the posting of the preprint. Therefore, the authors do not wish this work to be cited as a reference. Questions should be directed to the corresponding author.
Using applicable theorems for solving circle geometry problems: A correlational study of senior high school students’ academic performance in circle geometry
Authors: Enoch Suglo Kabinaa
Published: March 2024

The primary objective of this research was to examine the theorems students employ when solving circle geometry problems and how this impacts their academic performance in the subject. The study was designed around the null hypothesis that students' use of applicable theorems for tackling circle geometry questions do not significantly affects their academic achievement in this area. It was a quantitative study involving a total population of 460 students, with a sample size of 210 selected through probability systematic sampling. Data collection utilized a questionnaire and an achievement test instrument, while analysis methods included descriptive statistics and simple linear regression analysis. The study found that the use of relevant theorems in solving circle geometry problems has a statistically significant impact on students' academic performance in this field \({r}^{2}\)=.012, t(210) = 8.585, p(< .001). Given this significant finding, it is recommended that educators and curriculum developers highlight the importance of theorem application in teaching circle geometry to enhance students' understanding and performance in the subject.
WITHDRAWN: Doxorubicin Involves in Cardiomyocyte Ferroptosis by Inhibiting STAT3 Phosphorylation and Reducing GPX4 Expression
Authors: Gao Ge , Shen Cheng , Wang Manman , Ji Cuiling , Fang Fang , Liu Zhichao , Chen Wenqiang , Zhang Jinguo
Published: March 2024

The full text of this preprint has been withdrawn by the authors due to author disagreement with the posting of the preprint. Therefore, the authors do not wish this work to be cited as a reference. Questions should be directed to the corresponding author.
Probing the role of glycocalyx in host-microbe interactions with systematic modification of the glycomic surface
Authors: Lebrilla Carlito , Sheng Ying , Grijaldo-Alvarez Sheryl Joyce , Xie Yixuan , Wong Maurice
Published: March 2024

Glycosylation is a conserved post-translational modification by which oligosaccharides are attached to a macromolecule, typically proteins and lipids found on the cell surface. In particular, protein glycosylation play an important role in host-microbe interactions which can further help in describing microbial pathogenicity, recognition by the host immune system and host susceptibility to infections. Glycan-mediated host-microbe interactions were empirically investigated using glycan arrays; however, characterizing the cellular glycocalyx via in situ binding with cells has not been explored. In this research, we established a metabolic-engineered host cell model that generates controlled glycan structure phenotypes on the cell surface. Specifically, we produced host cell surfaces that were primarily fucosylated, sialylated, undecorated complex-type structures, and high mannose-type structures. The manipulated host cell N-glycomes were characterized and confirmed by liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis. To validate glycans involved during infection, we employed adherence assays which showed fucosylated N-glycans on the colon cell line HCT116 cell surface significantly increased the number of adhered Salmonella enterica serovar Typhimurium (S. Typhi) compared to the other glycan subtypes. Furthermore, we showed that adherence of S. Typhi to HCT116 cells could be blocked by co-incubation with free fucose monosaccharides. The results proved that fucose residues on host cells bind with S. Typhi during bacterial infection. Proteomic analysis showed that the glycoengineering did not change the abundances of membrane proteins, indicating that host protein expression did not contribute to the increased adherence of S. Typhi. Meanwhile, glycoproteomic analysis yielded site-specific N-glycosylation information. Glycopeptides were identified and quantified using a standard glycoproteomic workflow. Collectively, our results suggested the importance of glycans in host-microbe interactions and provided a novel insight into the significance of host glycome during pathogenesis.
Challenges in Trials on Neonatal Sepsis- Case of ProSPoNS Trial & Role of Central Endpoint Adjudication
Authors: Sinha Anju Pradhan , Raja Dilip K , Mahajan Kamlesh S , Gupta Subodh S , Poluru Ramesh , Kawade Anand S , Dhayma Girish , Sazawal Sunil , Bavdekar Ashish , Parida Sailajanandan , Nangia Sushma , Raut Abhishek V , Bethou Adhisivam , Devi Prabhabati , Gorpade Makrand , Fatima Tharika , Nayak Rashmita , Kapil Arti , Azam Mohd. , Khan Pearlin A , Pandey Ravindra Mohan , Arora Narendra Kumar
Published: March 2024

Background: Despite progress in reducing Infant mortality in India, neonatal mortality decline is slower, necessitating concerted efforts to achieve Sustainable Development Goal-3. A promising strategy aiming prevention of neonatal sepsis in high-risk, vulnerable, low birth weight neonates through an innovative intervention, including probiotic supplementation. This article communicates the decision by ProSPoNS trial investigators to establish a Central Endpoint Adjudication committee as an addendum to the published protocol in 'Trials 2021.'
Methods: In the pursuit of clarity regarding the primary outcome of Sepsis/PSBI in a clinical trial, a crucial decision was reached during the investigators' meeting at MGIMS Sevagram on 17th-18th August 2023. The unanimous consensus was to explicitly define "Physician diagnosed sepsis" as the primary study outcome, encompassing Sepsis/PSBI. This alignment aimed to synchronize the primary objective and outcome with the stated hypothesis, necessitating the establishment of a Central Endpoint Adjudication (CEA) process across all six trial sites.
To enact this, the CEA committee, chaired by an external Subject Expert and comprising Site Principal Investigators, a Trial Statistician, and a Microbiologist, will employ four criteria to determine 'Physician diagnosed sepsis' for each sickness event in a study participant. These criteria include Blood culture status, Sepsis screen status, PSBI/non-PSBI signs and symptoms, and the Clinical course during the event, including antibiotic usage. Importantly, this clarification maintains consistency with the approved study protocol (Protocol No.5/7/915/2012 Version 3.1 dated 14 Feb 2020), emphasizing the commitment to methodological transparency and adherence to predefined standards.
Results: The challenges faced in the trial implementation, such as complex multi-centric design, heterogeneity / extreme variation across sites, inconsistency with definition of sepsis in the neonatal/young infant population, remote vs. on-site training/monitoring during the Covid-19 Pandemic have been described and potential solutions to some of the challenges in clinical trials suggested.
Conclusions: The decision to utilize the guidance of a Central Endpoint Adjudication Committee has been suggested as a way forward in the ProSPoNS and other multicentre complex clinical trials.
Trial registration: Clinical Trial Registry of India (CTRI) CTRI/2019/05/019197. Registered
on 16 May 2019.
From Rainwater Harvesting to Groundwater Exploitation: Understanding theChanging Role of Farm Ponds and their Socio-economic Consequences in Maharashtra's Semi-Arid Region, India.
Authors: Warsi Taufique , Chemburkar Sarita , Yadav Ankita , Rupani Faraz , D'Souza Marcella
Published: March 2024

Groundwater plays a critical role in providing irrigation and drinking water in the drought-prone semi-arid region of Maharashtra, India. To address water scarcity, the government has promoted the construction of Farm Ponds (FPs) as a strategy to secure rural agrarian livelihoods and drought-proof the area. However, FPs, originally designed for rainwater harvesting, have now become commonly used as groundwater storage tanks, leading to overexploitation of groundwater by a few affluent farmers. This creates inequity in access to water by making it private and increases the vulnerability of other user communities. In this study, a systematic hydrogeological assessment was conducted, analysing 68 functional FPs constructed between 2009 and 2016 in six groundwater-vulnerable villages. The assessment focused on using Electrical Conductivity (EC) and Total Dissolved Solids (TDS) as parameters to delineate the zone of influence created by the feeding wells of FPs. Furthermore, the study utilized the Groundwater Survey and Development Agency’s (GSDA) recharge priority zone map to examine the distribution of lined FPs and identify areas where these ponds hinder recharge in high and moderate priority recharge zones and their socio-economic impacts on farmers were evaluated. The findings provide valuable insights into the relationship between the Zone of Influence and its socio-economic impacts on farmers, offering a comprehensive understanding of the distribution, practices, and ill effects of farm ponds.
The Effect of Sleep Deprivation on Executive Functions, Moral Decision Making and Social Cognition
Authors: Yilmaz Ilkay , Yildirim Erol
Published: March 2024

Objective
Sleep is a vital need for human life, and sleep deprivation is a common problem that can have serious consequences. Although the effects of acute sleep deprivation have been frequently reported in the literature, the effects of long-term sleep deprivation have not been well explained. This study investigated the effects of long-term sleep deprivation on executive functions, moral decision making, and social cognition.
Method
The study involved 85 participants who were between the ages of 20 and 40 and who has not any psychiatric or neurological disorders. The test performance averages of the groups with and without sleep problems were compared.
Results
The results showed that there was no significant difference in the performance of the two groups on any of the tests.
Conclusions
The results suggest that long-term sleep deprivation does not have a significant impact on executive functions, moral decision making and social cognition. These results are inconsistent with previous research that has shown that acute sleep deprivation can have a negative impact on these cognitive abilities. However, it is important to note that this study was relatively small, and participants are mostly university student. Further research is needed to confirm these findings.
Source and Distribution of Heavy Metals in Sediment Samples from Select Creeks of the Highly Urbanized Metro Vancouver Watersheds, Canada
Authors: Gampson Enoch , Dodd Matt , d'Entremont Marc V
Published: March 2024

Forty-seven samples collected from 23 creeks in Metro Vancouver, BC, Canada were analyzed to assess how different land use activities affect physicochemical properties in surface water and metal concentrations in sediments. The pH, total dissolved solids (TDS) and electrical conductivity (EC) in surface water samples ranged from 5.50 to 8.27, 14.0 to 410.0 ppm, and 19.0 to 903.0 µS/cm, respectively, with no discernible relationship between the surrounding land use and the parameters. However, land use influenced metal concentrations in the sediments with As, Cd, Cr, Cu, Pb, Ag, and Zn at some locations exceeding the Sediment Quality Guidelines (SQGs). The enrichment factor (EF) value, geo-accumulation index (Igeo), pollution load index (PLI) and concentration factor (CF) indicates most of the sediments are highly contaminated. The geo-accumulation index showed the study area contained extremely contaminated sediment and >64-fold increase due to high levels of Ba, Cr, Cu, Fe, Mn, Ni, Pb, V and Zn. The calculated contamination factors are found to fall in the following sequences: Cd>Ag>As>Pb>Zn>Mn>Cu>Ba>Cr>Ni>V>Fe>Hg in the study area. Creeks closer to highways with heavy vehicular activities reported significantly higher concentrations of metals. Principal component and cluster analyses revealed anthropogenic and natural processes enrich the sediments with metals. It is therefore important to put measures in place to curb increase in metal concentrations in creek sediments.
Rapid Genome Sequencing Shows Diagnostic Utility In Infants With Congenital Heart Defects
Authors: Durbin Matthew D. , Helvaty Lindsey R. , Posorske Alyx , Zhang Samuel , Huang Manyan , Li Ming , Abreu Daniel , Fairman Korre , Geddes Gabrielle C. , Helm Benjamin M. , Landis Benjamin J. , McEntire Alexis , Mitchell Dana K. , Ware Stephanie M.
Published: March 2024

Congenital heart disease (CHD) is the most common birth defect and a leading cause of infant mortality. CHD often has a genetic etiology and recent studies demonstrate utility in genetic testing. In clinical practice, decisions around genetic testing choices continue to evolve, and the incorporation of rapid genome sequencing (rGS) in CHD has not been well studied. Though smaller studies demonstrate the value of rGS, they also highlight the burden of results interpretation. We analyze genetic testing in CHD at two time-points, in 2018 and 2022–2023, across a change in clinical testing guidelines from chromosome microarray (CMA) to rGS. Analysis of 421 hospitalized infants with CHD demonstrated consistent genetic testing across time. Overall, after incorporation of rGS in 2022–2023, the diagnostic yield was 6.8% higher compared to 2018, and this pattern was consistent across all patient subtypes analyzed. In 2018, CMA was the most common test performed, with diagnostic results for CHD in 14.3%, while in 2022–2023, rGS was the most frequent test performed, with results diagnostic for CHD in 16.9%. Additionally, rGS identified 44% more unique genetic diagnoses than CMA. This is the largest study to highlight the value of rGS in CHD and has important implications for management.
Automatic summarization model based on clustering algorithm
Authors: Dai Wenzhuo , He Qing
Published: March 2024

Extractive document summary (EDS) is usually seen as a sequence labeling task, which the summary is formulated by sentences from the original document. However, the selected sentences usually are high redundancy in semantic space, so that the composed summary are high semantic redundancy. To alleviate this problem, we propose a model to reduce the semantic redundancy of summary by introducing the cluster algorithm in semantic space. We evaluate our model and perform significance testing on the CNN/DailyMail datasets compare with baselines.
Fhl2 deteriorates the progression in IL-1β-induced chondrocyte-like ATDC5 cells through the inhibition of mTOR and NF-ĸB signaling pathways
Authors: Li Yicheng , Wang Fei , Ji Baochao , Amat Abdusami , Cao Li
Published: March 2024

Background: The role of nuclear translocation in the pathogenesis of osteoarthritis (OA)has received increased attention in recent years, and extensive research has shown that Fhl2 functions as a nuclear transmitter by interacting with other nuclear transcription factors.We aimed to determine the role of Fhl2 in the cell model of osteoarthritis.
Methods: OA cartilage model was established by chondrocyte-like ATDC5 cells induced by 1% insulin-transferrin-selenium and then treated with interleukin-1β (IL-1β, 10ng/ml). Lentivirus transfection was employed to suppress the expression of Fhl2. Immunofluorescence and flow cytometry wereused to examine nuclear transcription and apoptosis, respectively. Western blotting was performed to analyze the expression of metabolism-related proteins, autophagy-related proteins, apoptosis-related proteins, NF-ĸB pathway-related proteins, and mTOR pathway-related proteins.
Results: The elevated expression of Fhl2 occurred in both the cytoplasm and the nucleus. Knockdown of Fhl2 could inhibit IL-1β-induced phosphorylation of NF-ĸB and stabilize the extracellular matrix (ECM) by decreasing MMP-3 and MMP-13 expression, to suppress type 2 collagen degradation in chondrocyte-like ATDC5 cells. Meanwhile, the knockdown of Fhl2-activated autophagy in IL-1β-treated chondrocytes, characterized by an increased LC3-II/LC3-I ratio and Beclin-1. The downregulation of Fhl2 inhibited IL-1β-induced apoptosis by suppressing the expression of BAX and caspase-3, as well as enhancing BCL-2 protein levels. The mechanism may be related to the phosphorylation of AKT and the decreased expression of p-NF-ĸB.
Conclusions: Fhl2 knockdown activated autophagy while suppressing inflammation, apoptosis, and ECM degradation. The mechanism behind these processes may be associated with the inhibition of mTOR and NF-ĸB signaling pathways.
Rare Fundus Lesions in Patients after SARS-Cov-2 Infection: A Multicenter and Multimodal Imaging Study
Authors: An Guangqi , Lei Bo , Wang Zhili , Yang Kaizhuan , Fan Dongsheng , Li Bing , Fu Ke , Fang Haixin , Zhang Min , Li Lin , Zhao Yu , Jin Xuemin , Du Liping
Published: March 2024

Purpose
To define the characteristics of fundus manifestations in patients after SARS-Cov-2 infection with multimodal imaging techniques.
Methods
This is a retrospective multicenter and multimodal imaging study including 90 patients. All patients with a visual complaint occurring immediately after SARS-Cov-2 infection were referred to six clinics between December 2022 and February 2023. Demographic information and the temporal relationship between SARS-Cov-2 infection and visual symptoms were documented. The characteristics of the fundus lesions were evaluated using multimodal imaging.
Results
Ninety patients from six hospitals were enrolled in this study, including 24 males (26.67%) and 66 (73.33%) females. Seventy-eight patients (86.66%) (146 eyes) were diagnosed with AMN. The AMN patients were primarily young women (67.95%). Sixty-eight patients (87.18%) had AMN in both eyes. Thirty-eight eyes (24.36%) included Purtscher or Purtscher-like lesions. optical coherence tomography and infrared retinal photographs can show AMN lesions well. Eleven cases were diagnosed with simple Purtscher or Purtscher-like retinopathy (2 cases, 2.22%), VKH or VKH-like uveitis (3 cases, 3.33%), MEWDS (2 cases, 2.22%), and ROCM (5 cases, 5.56%).
Conclusions
After SARS-Cov-2 infection, diversified fundus lesions were evident in patients with visual complaints. In this report, AMN was the dominant manifestation, followed by Purtscher or Purtscher-like retinopathy, MEWDS, VKH-like uveitis, and ROCM.
WITHDRAWN: Enhancing Wound Healing: Formulation and Evaluation of Acalypha Fruticosa Ethosomal Gel
Authors: Haq Mohammed Misbah Ul
Published: March 2024

The full text of this preprint has been withdrawn by the authors in order to comply with an institutional policy on preprints. Therefore, the authors do not wish this work to be cited as a reference.
WITHDRAWN: Wavelength selection algorithm for near-infrared spectra of volatile organic gases based on wave-cluster interval
Authors: Yue Yan
Published: March 2024

A novel wavelength selection algorithm, based on Wave Cluster Interval (WBIS), for near-infrared spectroscopy in the detection of volatile organic gases is presented. The algorithm employs a series selection mode, utilizing characteristic wavelength point cluster classification and absorption peak interval screening. Initially, cluster clustering is performed to preserve significant absorption peak features while avoiding mechanical division or random uncertain point changes in the algorithm. Subsequently, an improved moving window method is devised, and a greedy algorithm is employed to re-screen wavelength points within the same cluster class. This process ensures the retention of the optimal wavelength range, crucial for representing spectral characteristics and facilitating subsequent model predictions. Experimental validation was conducted using near-infrared spectral data of styrene, para-xylene, and o-xylene, employing four models: Partial Least Squares (PLS), Ridge Regression (RR), Support Vector Machine (SVM). The results demonstrate that, while maintaining model accuracy, the dataset can be reduced to 43.71%-36.35% of its original size. Additionally, utilizing a dataset comprising three gases (two concentrations each), as well as fully arranged and combined mixed gases, we conducted comparative experiments on three different CNN structures. The effectiveness of the proposed algorithm in reducing machine learning model complexity while ensuring prediction accuracy was validated through experimental comparisons before and after spectral waveform selection, with the CNN prediction models demonstrating a 90% increase in operational efficiency post-wavelength selection.
Comprehensive Assessment of PCM Integrated Roof for Passive Building Design: A Study in Energo-Economics
Authors: PEERZADA JAFFAR ABASS , Subramaniyan Muthulingam
Published: March 2024

There has been a notable surge in energy demand within the building sector of developing nations, particularly in the context of space cooling and heating, which constitute significant portions of energy consumption. The thermal performance of a building's roof slab plays a crucial role in determining these heating and cooling requirements. To address this, the utilization of Phase Change Material (PCM) to enhance the building's thermal energy storage capacity has emerged as an innovative strategy for reducing energy demand. This study assesses the thermal behavior of a building envelope integrated with macroencapsulated PCM in a real subtropical environment. Experimental setups include both a conventional slab unit (Ref–SU) devoid of PCM and a PCM (OM37) integrated slab unit (Exp–SU). Analysis entails examining variations in temperature, heat flow, thermal loadings, and maximum heat gain reduction. Economic metrics, such as electricity savings, simple payback periods, and CO2 emissions savings, are also scrutinized. The investigation aims to elucidate the efficacy and underlying parameters governing the PCM's performance in reducing thermal loads in the Indian city of Rupnagar. Findings indicate that the Exp–SU configuration reduces indoor temperatures by 4.0°C during sunny hours, resulting in 33.33% more electricity savings for space cooling compared to heating, with a simple payback period of 5.7 years. Additionally, the heat flux in Exp–SU is reduced by 60.6% compared to Ref–SU and thermal load by up to 49.8%. Furthermore, Exp–SU achieves a 44.24% reduction in CO2 emissions for space cooling compared to heating with a maximum heat gain reduction of 40.3%.
The verification of the utility of a commercially available phantom combination for quality control in contrast-enhanced mammography
Authors: Kim Jung-Ha , Kessell Meredith , Taylor Donna , Hill Melissa , Burrage John
Published: March 2024

Contrast-enhanced mammography (CEM) is being increasingly implemented clinically, providing much improved contrast between tumour and background structures, particularly in dense breasts. Although CEM is similar to conventional mammography it differs via an additional exposure with high energy X-rays (≥ 40 kVp) and subsequent image subtraction. Because of its special operational aspects, the CEM aspect of a CEM unit needs to be uniquely characterised and evaluated. This study aims to verify the utility of a commercially available phantom set (BR3D model 020 and CESM model 022 phantoms (CIRS, Norfolk, Virginia, USA)) in performing key CEM performance tests (linearity of system response with iodine concentration and background subtraction) on two models of CEM units in a clinical setting. The tests were successfully performed, yielding results similar to previously published studies. Further, similarities and differences in the two systems from different vendors were highlighted, knowledge of which may potentially facilitate optimisation of the systems.
TIPS Creation with Viatorr Stent-grafts for Variceal Hemorrhage: a Cohort Study in China
Authors: liu yuzhou , Sun Lin , zhou chuang , Xiang Hua
Published: March 2024

Objectives
To investigate the effectiveness and safety of transjugular intrahepatic portosystemic shunt (TIPS) insertion for the management of variceal hemorrhage in Chinese Viatorr era.
Methods
114 consecutive TIPS patients with variceal hemorrhage were included. Viatorr endoprostheses were used in all patients. The cumulative rates of variceal rebleeding, overall survival, shunt dysfunctions and overt hepatic encephalopathy (HE) were calculated by GraphPad Prism 9.5 (GraphPad Software Inc., San Diego, CA, USA).
Results
The overall survival rates at 1, 2, 3, and 4 years were 90.4%, 83.3%, 75.6%, and 69.2%, respectively. Variceal rebleeding rates increased over time, with rates of 9.1% at 1 year, 14.1% at 2 years, 17.9% at 3 years, and 25% at 4 years. Shunt dysfunctions showed a cumulative rate of 4.6% at 1 year, 8.5% at 2 years, 13.3% at 3 years, and 20.4% at 4 years and the risk of overt HE showed a cumulative rates of 14.2%, 17.9%, 23%, and 24.6% at 1, 2, 3, and 4 years, respectively.
Conclusion
TIPS using Viatorr stents is a beneficial approach for recurrent variceal bleeding. Yet the long-term complications including OHE development, stent dysfunctions, and rebleeding remain a main concern of physicians. It is valuable to consider these complications and inform TIPS candidates prior to the procedures.