bluuebunny/crossref_metadata_2025 huggingface dataset:
CRISPR-Cas13a-Based Assay for Accurate Detection of OXA-48 and GES Carbapenemases
Authors: Ortiz-Cartagena Concha , Pablo-Marcos Daniel , Fernández-García Laura , Blasco Lucía , Pacios Olga , Bleriot Inés , Siller María , López María , Fernández Javier , Aracil Belén , Fraile-Ribot Pablo Arturo , García-Fernández Sergio , Fernández-Cuenca Felipe , Hernández-García Marta , Cantón Rafael , Calvo-Montes Jorge , Tomás María
Published: July 2023

Carbapenems are one of the last-resort antibiotics for defense against multidrug-resistant pathogens. Multiple nucleic acid amplification methods, including multiplex PCR, multiplex loop-mediated isothermal amplification (LAMP) and multiplex RPAs, can achieve rapid, accurate, and simultaneous detection of several resistance genes to carbapenems in a single reaction.
Randomised controlled trial of cultural-adapted and programme-adopted cognitive behavioural therapy for children and adolescents’ anxiety in Japan: protocol for a Multi-, Inter-, and Cross-cultural Clinical Child Study (MIXCS)
Authors: Takashina Hikari N , Ueda Satsuki , Sakai Mie , Takahashi Fumito , Sato Hiroshi , Hudson Jennifer L , Rapee Ronald M , Ishikawa Shin-ichi
Published: July 2023

Introduction

The primary objective of the Multi-, Inter-, and Cross-cultural Clinical Child Study (MIXCS) is to evaluate the hypothesis that the effects of cultural-adapted cognitive behavioural therapy (CA-CBT) and programme-adopted cognitive behavioural therapy (PA-CBT) for children and adolescents’ anxiety are both superior to a psychological control (moral education control: MEC) for reducing child and adolescent anxiety disorders and symptoms as well as related constructs. The secondary objective is to explore commonalities and differences in therapy factors between CA-CBT and PA-CBT.

Method and analysis

The study has been designed as a randomised, controlled and assessor masked multicentre superiority trial with three groups: CA-CBT, PA-CBT and MEC. Primary outcome is remission of primary anxiety disorders evaluated by independent evaluators. Secondary outcomes are clinician’s severity ratings, child self-reported anxiety symptoms, depressive symptoms, cognitive errors and family accommodation, as well as parent-reported anxiety symptoms, and family accommodation. Competence and adherence of treatment, therapy factors in treatment sessions are also measured based on behavioural observation. Finally, satisfaction and comprehension are collected. We aim to recruit at least 99 families for the analysis. Treatment will be delivered weekly for 10 sessions and assessment will be conducted 2 weeks before the treatment (pre), 3 months after the base date when the treatment starts (post), 6 months (six months follow-up) and 12 months (12 months follow-up) after the postassessment.

Ethics and dissemination

The MIXCS study was approved by Doshisha University Research Ethics Review Committee, Kwansei Gakuin University Institutional Review Board for Medical and Biological Research Involving Human Subjects and Shinshu University Certified Review Board of Clinical Research. Regardless of the results, the primary outcome will be published in a journal, and if the efficacy and effectiveness of CA-CBT and/or PA-CBT are empirically supported, the authors will encourage dissemination of the programmes including the assessment system through key stakeholders in education, health, and welfare areas.

Trial registration number

UMIN000038128
Capacity building of district health management teams in the era of provincial health administration reform in the Democratic Republic of Congo: a realist evaluation protocol
Authors: Bosongo Samuel , Belrhiti Zakaria , Chenge Faustin , Criel Bart , Marchal Bruno
Published: July 2023

Introduction

In 2006, the Congolese Ministry of Health developed a health system strengthening strategy focusing on health district development. This strategy called for reforming the provincial health administration in order to better support the health district development through leadership and management capacity building of district health management teams. The implementation is currently underway, yet, more evidence on how, for whom and under what conditions this capacity building works is needed. The proposed research aims to address this gap using a realist evaluation approach.

Methods and analysis

We will follow the cycle of the realist evaluation. First, we will elicit the initial programme theory through a scoping review (completed in December 2022, using MEDLINE, Health Systems Evidence, Wiley Online Library, Cochrane Library, Google Scholar and grey literature), a review of health policy documents (completed in March 2023), and interviews with key stakeholders (by June 2023). Second, we will empirically test the initial programme theory using a multiple-embedded case study design in two provincial health administrations and four health districts (by March 2024). Data will be collected through document reviews, in-depth interviews, non-participant observations, a questionnaire, routine data from the health information management system and a context mapping tool. We will analyse data using the Intervention-Context-Actor-Mechanism-Outcome configuration heuristic. Last, we will refine the initial programme theory based on the results of the empirical studies and develop recommendations for policymakers (by June 2024).

Ethics and dissemination

The Institutional Review Board of the Institute of Tropical Medicine and the Medical Ethics Committee of the University of Lubumbashi approved this study. We will also seek approvals from provincial-level and district-level health authorities before data collection in their jurisdictions. We will disseminate the study findings through the publication of articles in peer-reviewed academic journals, policy briefs for national policymakers and presentations at national and international conferences.
Cancer-related breathlessness: opioids other than morphine – comprehensive literature review
Authors: Sakaguchi Tatsuma
Published: July 2023

Introduction

Although there is low-quality evidence, there has been an increase in publications on the experience of evaluating and managing cancer-related breathlessness using opioids other than morphine.

Methods

The author conducted a non-systematic literature review in the PubMed/Medline and Embase until 4 October 2022. Eligible studies have evaluated the efficacy of opioids other than morphine for cancer-related breathlessness. Studies focused on sedation, anaesthesia, paediatric patients, opioid toxicity or basic research were excluded. Reviews/meta-analyses and non-English language publications were also excluded.

Results

A total of 1556 records were identified, of which 23 studies including 469 patients who were treated with fentanyl (n=223), oxycodone (n=171) and hydromorphone (n=75) were considered eligible. Six phase II randomised clinical trials (RCTs), four observational studies and four case reports of fentanyl were found. For breathlessness on exertion, fentanyl yielded promising results, but no RCT showed significant superiority of fentanyl to placebo or morphine. For terminal breathlessness, three RCTs, five non-randomised or observational studies and one case report on oxycodone or hydromorphone were found. Although the results of the observational studies suggested that oxycodone and hydromorphone might be effective alternatives to morphine, the superiority over placebo or non-inferiority to morphine had not been demonstrated in the RCTs.

Conclusion

As an alternative to morphine, the author recommends fentanyl for breathless crisis or breathlessness on exertion, and oxycodone or hydromorphone for terminal breathlessness in advanced cancer. Larger and well-designed studies based on firm research policies are needed to confirm this current knowledge.
Do physical symptoms predict psychological issues in patients with cancer?: the Memorial Symptom Assessment Scale—Short Form
Authors: Webber Katherine , Davies Andrew Neil , Waghorn Melanie
Published: July 2023

Objectives

This study aimed to determine if individual physical symptoms were predictive of psychological disorders.

Methods

This study was a secondary analysis of data from two studies which used the Memorial Symptom Assessment Scale—Short Form (MSAS-SF) to assess both physical and psychological symptoms. Correlation between individual symptoms and the validated psychological subscale (MSAS-PSYCH) were performed using Spearman’s coefficient. Linear regression analysis was performed to assess whether correlated symptoms predicted the presence of psychological disorders.

Results

1507 patients’ data were analysed. The physical symptoms of pain, lack of energy, drowsiness, dizziness, constipation, ‘feeling bloated’ and ‘I don’t look like myself’ were correlated with MSAS-PSYCH. Other physical symptoms existed independently to psychological symptoms. None of these physical symptoms were independently predictive of a mood disorder.

Conclusions

This study presents a large data set evaluating psychological symptom correlations. There are certain physical symptoms which correlate with mood disorders, but these are not independently predictive. It is not known whether the correlative data are cause or effect. Comprehensive assessment remains essential to assess all problems.

Trial registration number

The trial registered was at National Institute for Health Research Clinical Research Network Portfolio (Central Portfolio Management System (CPMS) ID 30723) Integrated Research Application System Identification (IRAS) ID 198753.
Quality of death educational programme in a national reference palliative care unit
Authors: De Oliveira Livia Costa , Rosa Karla Santos da Costa , Salman Amirah Adnan , Salman Manuela Samir Maciel , Simões Alessandra Gomes , Siqueira Alex Sandro de Azeredo , Richard Amanda Alves Orsini , Yamaguchi Angelica , Ribeiro João Barroso , Vinicius da Silva Marcus , Bolzan Mônica , Freitas Renata , Bryan Liz
Published: July 2023

Objective

To report the experience of offering the Quality End of Life Care for All (QELCA) Programme, highlighting the distinct methodology for the training of health professionals.

Development

The QELCA Programme, intellectual property of St Christopher’s Hospice, was offered to seven health professionals working in the hospital palliative care unit at the National Cancer Institute, between June and December 2022, with the support of Premier Institute. The programme, which originates in the UK, has been evaluated there and is currently being evaluated in Hong Kong, and is delivered in two phases: (1) a 5-day immersion programme; (2) monthly sessions of Action Learning for 6 months. Participants realised that communication between members of the multidisciplinary team, as well as between health professionals and patients/loved ones, was one of the key challenges for achieving quality of death in the hospital palliative care unit. This insight empowered them to drive forward significant changes in practice that promise to improve quality of care.

Conclusion

The QELCA Programme enabled participants to engage in active problem-solving to promote the relief of suffering of patients and their families in end-of-life care.
The Analysis of Muscle Volume Measured by Bioelectrical Impedance in Patients with Hepatocellular Carcinoma Treated with First-Line Atezolizumab plus Bevacizumab Combination Therapy or First-Line Lenvatinib
Authors: Chihiro Kikugawa , Kawaoka Tomokazu , Uchikawa Shinsuke , Kinami Takahiro , Yamasaki Shintaro , Kosaka Masanari , Johira Yusuke , Yano Shigeki , Amioka Kei , Naruto Kensuke , Ando Yuwa , Yamaoka Kenji , Teraoka Yuji , Uchida Takuro , Fujino Hatsue , Nakahara Takashi , Ono Atsushi , Murakami Eisuke , Okamoto Wataru , Yamauchi Masami , Miki Daiki , Tsuge Masataka , Imamura Michio , Aikata Hiroshi , Oka Shiro
Published: July 2023

Introduction: Measurements of body composition, such as the skeletal muscle index (SMI), are useful for predicting prognosis in hepatocellular carcinoma (HCC). This study aimed to analyze the relationship between skeletal muscle changes during therapy with atezolizumab plus bevacizumab (Atezo + Beva) or lenvatinib (Len) and the association between SMI and prognosis. Methods: Patients with advanced HCC and Child-Pugh A status received Atezo + Beva or Len as first-line systemic chemotherapy. We assessed prognosis and body composition obtained by bioelectrical impedance analysis. Results: A total of 109 patients received treatment (Atezo + Beva, n = 47; Len, n = 62). During treatment, the arm SMI was reduced in the Len group and maintained in the Atezo + Beva group. The extracellular water to total body water ratio (ECW/TBW) increased significantly in both groups during treatment. In the Atezo + Beva group, no factor was associated with prognosis. Multivariate analysis showed that in the Len group, the arm SMI (hazard ratio [HR], 0.5; 95% CI: 0.26–0.89; p = 0.02), ECW/TBW (HR: 2.7; 95% CI: 1.21–6.01; p = 0.01), and Child-Pugh score (HR: 2.3; 95% CI: 1.31–6.13; p = 0.004) were associated with progression-free survival. Conclusion: Assessing body composition with BIA before Atezo + Beva and Len treatment may be useful.
Geographic Market Definition in Commercial Health Insurer Matters: A Unified Approach for Merger Review, Monopolization Claims, and Monopsonization Claims
Authors: Haas-Wilson Deborah , Zetenyi Kristof , Gorin Brian
Published: July 2023

We provide a methodology for geographic market definition when the product(s) being purchased or sold has an intrinsic geographic component, such as (1) the sale of commercial health plans and (2) the purchase of health care providers’ services by commercial health plans. In these situations, we show that a straightforward application of the Horizontal Merger Guidelines issued by the U.S. Department of Justice and the Federal Trade Commission (hereafter, Guidelines) that uses the customer or supplier location to define the geographic market is not sufficient and can result in markets that are unintuitively small. This is often addressed by applying an assumption about aggregating based on similar competitive conditions. The practice of relying on the assumption of similar competitive conditions across counties, metropolitan statistical areas, or other geographic areas, without a methodology to support this assumption, could lead to market definitions that are too narrow or too broad and could influence the assessments of the extent of market concentration and the presence or absence of market power. We outline a framework that is consistent with the Guidelines and does not require a reliance on the assumption of aggregation based on similar competitive conditions.

JEL Classification L12, L40, K21, D42, I11
Poverty, inequality, and redistribution: An analysis of the equalizing effects of social investment policy
Authors: Sakamoto Takayuki
Published: July 2023

Social investment (SI) policies have been implemented by governments of affluent countries in hopes of safeguarding against new social risks and mitigating social exclusion by encouraging employment and making it easier for parents to balance work and family. Governments hope that human capital investment (education and job training) will better prepare workers for jobs, promote their employment and social inclusion, and reduce poverty. This article investigates whether SI policies contribute to lower poverty and inequality by analyzing data from 18 Organization for Economic Cooperation and Development countries between 1980 and 2013. The analysis finds, first, that SI policies (education and active labor market policy (ALMP)) alone may be less effective in generating lower poverty and inequality without redistribution, but when accompanied and supported by redistribution, SI policies are more effective in creating lower poverty and inequality. I propose the explanation that SI policies create lower-income poverty and inequality by creating individuals and households that can be salvaged and lifted out of poverty with redistribution, because SI policies help improve their skills and knowledge and employability, although they may be not quite able to escape poverty or low income without redistribution. As partial evidence, I present the result that education is associated with a lower poverty gap in market income. The analysis also finds that education and ALMP produce lower poverty and/or inequality in interaction with social market economies that redistribute more, and that augments the equalizing effects of education and ALMP. The results, thus, suggest the complementary roles of SI policies and redistribution.
ARCO Mapping the Cognitive Dynamics of Communication Expectations: An Approach to Designing Usable Content Based on Audience Expectations
Authors: St.Amant Kirk
Published: July 2023

The usability of items is connected to cognition, or how the brain processes information. Many of the related processes occur subconsciously and are guided by the mental models individuals have created based on their experiences. The better communication professional and communication students understand such dynamics, the more effectively they can create usable content for an audience. This article presents an approach, the Actualization, Recognition, Categorization, Operationalization (ARCO) method, for identifying the mental models that influence usability expectations. Individuals can use the results of this process to create content that better addresses an audience’s usability expectations.
Depression, anxiety, insomnia and dysmenorrhea in stressed fingolimod-treated women with multiple sclerosis
Authors: Gammoh Omar , Ennab Wail
Published: July 2023

Objective

This study examined the prevalence and correlates of depression, anxiety, insomnia, and dysmenorrhea in stressed fingolimod-treated women with multiple sclerosis.

Methods

This cross-sectional study recruited female patients diagnosed with multiple sclerosis and high stress scores from Al-Bashir Hospital in Jordan. Depression was assessed by the Patient Health Questionnaire (PHQ-9); anxiety by the Generalized Anxiety Disorder (GAD-7) scale; insomnia by the Insomnia Severity Index (ISI-A) scale; and dysmenorrhea severity by a measure assessing working ability, location, intensity, days of pain, and miscellaneous dysmenorrhea symptoms (WaLIDD).

Results

A total of 129 patients were recruited for the study. Severe depression was reported in 55.8%, severe anxiety in 62.0%, severe insomnia in 36.4%, and severe dysmenorrhea in 23.3%. Multivariate analyses revealed that depressive symptoms were associated with dysmenorrhea (OR = 3.55, 95% CI = 1.56–8.12, p = 0.003); anxiety symptoms with “not using dysmenorrhea analgesics” (OR = 2.74, 95% CI = 1.16–6.46, p = 0.02) and dysmenorrhea symptoms (OR = 4.74, 95% CI = 1.94–11.59, p = 0.001); insomnia symptoms with age above 30 years (OR = 4.34, 95% CI = 1.64–11.51, p = 0.003); and dysmenorrhea symptoms with the presence of chronic diseases (OR = 4.21, 95% CI = 1.28–13.92, p = 0.02), anxiety symptoms (OR = 3.03, 95% CI = 1.18–7.73, p = 0.02), and insomnia symptoms (OR = 3.00, 95% CI = 1.18–7.64, p = 0.02).

Conclusion

Stressed women with multiple sclerosis in Jordan experience high rates of depression, anxiety, insomnia, and dysmenorrhea. Characteristics related to these conditions may help clinicians to identify those at risk. Longitudinal studies are needed to determine the causal nature of these associations.
Politics on the stock market? Political investorism as a form of political participation
Authors: Christensen Henrik Serup , Brännlund Anton
Published: July 2023

Political investorism involves the use of financial investments to promote political aims, but has, with some recent exceptions, received scarce attention from political scientists although there are valid theoretical reasons to consider this a new form of political participation. Here, we add new knowledge to this research agenda by examining empirically whether political investorism constitutes a distinct mode of political participation. Furthermore, we explore the characteristics of political investors and why they use political investorism. We examine these issues using an original survey from Finland ( n = 1065). Our results demonstrate that political investorism constitutes a distinct mode of participation that in particular appeals to young and well-educated women living in an urban setting. Finally, cultural ideological divisions (measured with GAL-TAN: Green-Alternative-Libertarian and Traditional-Authoritarian-Nationalist) mediate socio-demographic characteristics when explaining participation.
Robots and care of the ageing self: An emerging economy of loneliness
Authors: Pratt Geraldine , Johnston Caleb , Johnson Kelsey
Published: July 2023

What happens when caring for the ageing population is so devalued that robots are deployed to care for our elders? We examine the growing employment of companion robots in elder care as one response to a critical labour shortage and loneliness epidemic shared across the Global North. Reflecting on interviews conducted with robot engineers, researchers, NGO care providers and local government, we examine five robots under development or in use in the UK and the USA. We ask if machines providing emotional and social care signal a diminishment of what it means to be human or if robots and automation present a promising solution to our elder care crisis. We do not evaluate the efficacy of robotic technology but identify and question assumptions concerning what it means to be human in modernity and examine companion or social robots at a moment of crisis and the substantive reorganisation of social reproduction wrought by neoliberal austerity. We end by calling for a reimagining of elder care, in which the care of our elders is radically revalued and where robots assist and support workers in their difficult and skilled labour of care.
Connecting the Dots: Potential Interactions Between Sex Hormones and the Circadian System During Memory Consolidation
Authors: Boyd Hannah M. , Frick Karyn M. , Kwapis Janine L.
Published: July 2023

Both the circadian clock and sex hormone signaling can strongly influence brain function, yet little is known about how these 2 powerful modulatory systems might interact during complex neural processes like memory consolidation. Individually, the molecular components and action of each of these systems have been fairly well-characterized, but there is a fundamental lack of information about how these systems cooperate. In the circadian system, clock genes function as timekeeping molecules that convey time-of-day information on a well-stereotyped cycle that is governed by the suprachiasmatic nucleus. Keeping time is particularly important to synchronize various physiological processes across the brain and body, including those that regulate memory consolidation. Similarly, sex hormones are powerful modulators of memory, with androgens, estrogens, and progestins, all influencing memory consolidation within memory-relevant brain regions like the hippocampus. Despite clear evidence that each system can influence memory individually, exactly how the circadian and hormonal systems might interact to impact memory consolidation remains unclear. Research investigating either sex hormone action or circadian gene function within memory-relevant brain regions has unveiled several notable places in which the two systems could interact to control memory. Here, we bring attention to known interactions between the circadian clock and sex hormone signaling. We then review sex hormone–mediated control of memory consolidation, highlighting potential nodes through which the circadian system might interact during memory formation. We suggest that the bidirectional relationship between these two systems is essential for proper control of memory formation based on an animal’s hormonal and circadian state.
Effect of teak wood on recycled HDPE/pine wood composites subjected to termite attack and accelerated weathering
Authors: Cruz-Estrada Ricardo H , Guillén-Mallette Javier , López-Naranjo Edgar J , Zacarías-Calderón Edgar
Published: July 2023

This study aimed to investigate the impact of including teak wood in recycled high-density polyethylene wood plastic composites (WPC) with pine wood on their resistance to degradation caused by termite attack and accelerated weathering. A 23 factorial experimental design was conducted with three repetitions in the center to analyze the weight loss and termite mortality during the experiments. The factors studied were the days of exposure to accelerated weathering, days of exposure to termite attack, and the concentration of teak wood in the composite. Surface characterizations (SEM and FTIR) were carried out to analyze the exposed surfaces and determine the chemical modification of the composite components. The results showed that the WPC manufacturing process promotes a heterogeneous distribution of the wood particles, being greater within the center of the samples than on the surface. Specimens exposed to both accelerated weathering and termite attack resulted in a certain weight loss and termite mortality, depending on the material, conditions of exposure, and the content of teak wood in the WPC. When those compounds were subjected to accelerated weathering followed by termite attack they exhibited a higher termite attack. The presence of teak wood in the WPC produced a reduction in the effects of termite attack and accelerated weathering on weight loss and an increase in termite mortality compared to the WPC with only pine wood, as teak wood contains extractables with termiticidal action. The lowest value of weight loss (0.06%) was observed for the WPC with the highest amount of teak wood with termite attack, resulting in a termite mortality rate of 100% after 17 days of exposure.
Searching for role models: The case of Malferida the healthy cola with nothing to hide
Authors: Donaldson Colin , Villagrasa Jorge
Published: July 2023

Gendered barriers that have traditionally impeded entry into entrepreneurship are lessening. Nonetheless, there is still a clear need to further encourage female students into an entrepreneurial career pathway. To do so, traditional classroom discourse that promotes the masculinised concept of the ‘heroic’ entrepreneur who experiences overnight success needs to be challenged. By providing a case study of a young successful female entrepreneur we open a pathway beyond a narrow vision of the homogenous entrepreneur driven by purely profit-seeking motives. It is well recognised that the socialisation process differs between individuals, making it important to consider the lived experiences of a variety of entrepreneurs that can appeal to the idiosyncratic needs of our students. At the same time, to amplify the value of such narratives they need to be connected to what we already know. The overriding aim of this teaching case is to offer a narrative of a successful female entrepreneur that can be used as a tool to stimulate an entrepreneurial mindset in students.
How Sustainable Are Tourist Destinations Worldwide? An Environmental, Economic, and Social Analysis
Authors: Nguyen Dinh Tam , Kuo Kuo-Cheng , Lu Wen-Min , Nhan Dinh Thanh
Published: July 2023

Sustainable tourism is the idea of managing the negative impacts or potential for serious harm to the economic, environmental, or social elements of a destination, and thus reaching the goals of sustainable development. This research benchmarks the sustainability of 111 tourist destinations throughout the world, using an advanced integration of a two-stage network DEA under the meta-frontier concept, directional distance function, and network-based ranking methods. The empirical outcomes of these analyses clarify that the sources of sustainable inefficiencies are the self-production process and the technology gap among the tourism regions, rather than the capacity of utilizing the input resources or maintaining the production outcomes. The network-based ranking emphasizes the sufficiency and deficiency of each place, and provides a map of reference among destinations. Based on these, the article reports some managerial suggestions, theoretical implications, and future research directions.
I Don’t Know Why . . . I Swallowed That Lie
Authors: Poulos Christopher N.
Published: July 2023

Following the logic and structure of the children’s nursery rhyme “I don’t know why she swallowed a fly,” this autoethnographic performance essay explores the contours of woundedness, anxiety, self-respect, and recovery. I write my way through the wounds I have suffered from lies casually thrown my way by family, institutions, and culture—and land, somewhat surprised and surprisingly, in love.
Influences of High School Physical Learning Environments on Students’ Anxiety in China
Authors: Li Mengqi , Lu Zhipeng , Xu Leiqing
Published: July 2023

Background:

High school students are at an increased risk of developing generalized anxiety disorder (GAD) due to significant pressure to achieve academic success.

Aim:

Although it is known that a school’s physical learning environment can influence students’ GAD, there is limited research examining this relationship. To fill this knowledge gap, a cross-sectional study was conducted among 230 students from two high schools in China.

Methods:

A survey questionnaire captured students’ GAD self-evaluations (dependent variables), perceptions/preferences of their school physical environment (independent variables), and social and personal conditions (confounding variables). Bivariate analysis showed that students’ GAD scores were associated with multiple factors related to the learning environment, physical activities, and personal characteristics. The multivariate analysis examined the relationship between GAD scores and physical learning environment variables while controlling for confounding variables.

Results:

The results indicated that adequate lighting ( B = −0.154, p = .029) and perceived effectiveness of using self-service cafeterias in reducing anxiety ( B = −0.138, p = .044) were significantly associated with GAD scores.

Conclusions:

These findings provide evidence for the importance of designing high schools with students’ mental health in mind. Specifically, school administrators and designers should consider how to improve the physical learning environment by incorporating natural light, a self-service cafeteria, and spaces for physical activities to promote students’ mental well-being.
Survival Trends and Profiling of Gastric Mixed Adenoneuroendocrine Carcinoma (gMANEC) in the Current Era
Authors: Gupta Shreya , McDonald James D. , Rossi Alexander J. , Hernandez Jonathan M. , Davis Jeremy L. , Blakely Andrew M.
Published: July 2023

Background:

Gastric mixed adenoneuroendocrine carcinoma (gMANEC) is a histopathologic diagnosis with at least 30% each of exocrine and endocrine components. Although prognosis is thought to be driven by the relative exocrine or endocrine dominance, gMANEC has been clinically treated as gastric adenocarcinoma (gAC). The overall survival of gMANEC as compared to gastric neuroendocrine carcinoma (gNEC) or gAC remains undefined.

Methods:

Using the National Cancer Database, patients with gastric tumors were queried from 2004 to 2016 for gMANEC, gNEC, and gAC histologies. Demographic and clinicopathologic features were recorded. Univariate and multivariate Cox proportional hazards analyses were performed to delineate factors associated with overall survival (OS).

Results:

Overall, 404 patients diagnosed with gMANEC were identified. Patients had a median age 68 years, were majority male, and predominantly Caucasian. Gastric MANEC was more frequently poorly differentiated (73%vs 52% (gAC) vs 20% (gNEC), P < .001) with lymphovascular invasion (57%vs 38%vs 27%, P < .001) and lymph node involvement (59%vs 49%vs 36%, P < .001); these factors were associated with worse OS on univariable analysis. Finally, tumors >5 cm and lymph node involvement were independent predictors of worse survival. The median OS of patients with gMANEC was 41.5 months.

Conclusion:

Gastric MANEC and gAC have a similarly dismal prognosis and thus should be continued to treat like gAC. Pathologic nodal metastasis, tumor size and grade are useful prognostic factors.
Targeting TIM-3 for hematological malignancy: latest updates from the 2022 ASH annual meeting
Authors: Tan Jiaxiong , Tan Huo , Li Yangqiu
Published: July 2023

T cell immunoglobulin domain and mucin domain-3 (TIM-3) is an important immune checkpoint (IC) protein in cancer immunosuppression that is considered a novel target for immunotherapy. Moreover, TIM-3, an immuno-myeloid regulator, is highly expressed on the cells of several solid tumors and myeloid leukemia stem cells (LSCs). TIM-3 blockade was shown to have dual effects for directly inhibiting leukemia cells and restoring T cell activation. We summarize several of the latest reports on the role of TIM-3 in immunotherapy for hematological malignancies from the 2022 ASH Annual Meeting (ASH2022).
Case Report: Optical coherence tomography angiography findings in radiation retinopathy
Authors: Ammari Wafa , Zaghdoudi Asma , Berriche Olfa , Messaoud Riadh
Published: July 2023

We report the observation of a 31-year-old patient followed for a nasopharyngeal carcinoma since 2009, treated by locoregional radiotherapy, with a cumulative dose of 70 Gray.  This case presented all ocular complications of radiotherapy; radiation retinopathy (RR), which is the most severe complication, could be diagnosed earlier and have a better prognosis if optic coherence tomography angiography (OCTA) was performed.

She presented with a progressive decline in bilateral visual acuity. Ophthalmologic examination revealed bilateral posterior subcapsular cataract, radiation retinopathy, and optic neuropathy. The OCT B-scan showed more pronounced macular edema in the right eye.  The OCTA revealed enlargement of the central avascular zone and loss of the deep and superficial retinal vascular network. The patient received three consecutive monthly intravitreal injections of anti-vascular endothelial growth factor (VEGF), without improvement in visual acuity.

The aim of this case report is to present the contribution of OCT-A in the diagnosis of radiation maculopathy, and attribute these changes to ischemia at the level of the retinal vascular network.
Past and future wars on TV: High-end drama series and national identity
Authors: Engelstad Audun
Published: July 2023

War on film and in television series reflects a nation’s preoccupation with war and how warfare shapes conceptions of history. The war genre is inherently national, as it deals with a nation’s heroic moments and traumas. Stories about war address a nation’s collective moral values, cultural heritage and other tropes of national identity markers. This article will discuss two Norwegian war dramas made for TV, one set in the past (Kampen om tungtvannet[The Saboteurs] [2015]) and one set in a not-too-distant future (Okkupert[Occupied] [2015–20]). This article discusses how these war dramas articulate themes about history and nationality.
Autophagy orchestrates the crosstalk between cells and organs
Authors: Piletic Klara , Alsaleh Ghada , Simon Anna Katharina
Published: July 2023

Over the recent years, it has become apparent that a deeper understanding of cell‐to‐cell and organ‐to‐organ communication is necessary to fully comprehend both homeostatic and pathological states. Autophagy is indispensable for cellular development, function, and homeostasis. A crucial aspect is that autophagy can also mediate these processes through its secretory role. The autophagy‐derived secretome relays its extracellular signals in the form of nutrients, proteins, mitochondria, and extracellular vesicles. These crosstalk mediators functionally shape cell fate decisions, tissue microenvironment and systemic physiology. The diversity of the secreted cargo elicits an equally diverse type of responses, which span over metabolic, inflammatory, and structural adaptations in disease and homeostasis. We review here the emerging role of the autophagy‐derived secretome in the communication between different cell types and organs and discuss the mechanisms involved.
Kobiety i kobiecość w twórczości literackiej Wandy Maleckiej
Authors:   Uniwersytet Warszawski, Westermark Katarzyna
Published: July 2023

Wanda Malecka’s literary work remains a proof of her gradual acknowledgment of woman role in society. In the 1810’s and 1820’s she was experimenting with different Enlightment era literary genres, such as dialogue, fable and anecdote. The representation of femininity portrayed in those works was consequently mocking. The romantic poem “Wyjątek z historycznego poematu Wanda” marks the second phase, as it brings heroic lead female character, attributed with male features and desires. In the 1830’s the author focused on short sentimental novels, where the issues concerning gender inequalities were most visible.
Entre marino y campesino. Apropósito del arte de contar historias
Authors: Almeyda Sarmiento Juan David
Published: July 2023

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Los Estados Unidos de Banana: re-construcción de la identidad puertorriqueña en tiempos post-neocoloniales
Authors: Castillo Balmaceda Sandra
Published: July 2023

Este trabajo analiza la novela Los Estados Unidos de Banana de la escritora puertorriqueña Giannina Braschi a partir de conceptos desarrollados por la intelligentsia caribeña como la transnación y el lenguaje nación, y en el marco del escenario neocolonial en el que está inmersa la diáspora puertorriqueña y latinoamericana en los Estados Unidos. La tesis central que planteo en este texto es que Braschi aboga por una inversión epistémica que revierta procesos de aculturación a los que fueron sometidos los puertorriqueños y latinos y a partir de eso impulsar la renegociación de elementos identitarios. Asimismo, este trabajo estudia el entramado simbólico construido por Braschi para develar mecanismos de dominación neocolonial como la zombificación y la normativización de los ciudadanos que han migrado a Estados Unidos.
A-normalidad quebrada Reseña del libro ¡Y qué…! De Víctor Raúl Jaramillo Restrepo
Authors: Zuluaga Mesa David Esteban
Published: July 2023

Escribir sobre sí mismo es el reflejo de que nos hemos emancipado de nosotros mismos y pretendemos ponernos en el centro del mundo. Por eso la autobiografía de un poeta no puede comprenderse como las palabras de un hombre que habla de sí; sino como las palabras de un hombre que se habla a sí mismo, que se emancipa del mundo para privilegiar el propio, que se sumerge en la más honda soledad para regocijarse en su más profunda intimidad.Retirarse del mundo exige tres cosas fundamentales: soledad: para desnudar el pensamiento. Voluntad filosófica: para no desear conocer lo inefable, para anular la necesidad de construir el principio de todo. Y espíritu: para no perder el camino cuando vamos de la sima a la cima, para no caer de rodillas ante los mandatos y la desproporcionada ambición de la sociedad fratricida.
Liberalismo Burgués en SAB de Gertrudis Gómez de Avellaneda y torquemada en la hoguera de Benito Pérez Galdós: intelectualidad y poder en el siglo XIX
Authors: Castillo Balmaceda Sandra Milena
Published: July 2023

Este artículo analiza las novelas cortas Sab de Gertrudis Gómez de Avellaneda y Torquemada en la hoguera de Benito Pérez Galdós a partir de sus puestas en escena del neoliberalismo burgués. Contrario a las lecturas de Sab que ven esta novela como antiesclavista, mi tesis central apunta a que la novela hace parte de un proyecto de construcción de la emergente nación cubana que busca configurar un nosotros excluyente criollo, blanqueado y racional. La novela de Pérez Galdós patentiza, a diferencia de la de Gómez de Avellaneda, una actitud crítica frente a la ideología neoliberal burguesa a partir de la parodia del ethos que la sustenta. Pérez Galdós muestra lo falso de ese ethos mediante la caracterización de su personaje central y la capacidad de ese personaje para adaptarse a las cambiantes condiciones sociales. Este artículo hace uso de la tematología como metodología de análisis. Los textos son analizados a partir de temáticas similares que permiten adentrarse en las similitudes y divergencias de las posturas de los autores frente a esas temáticas.
Homoerotismo y sociedad: una polifonía de fuerzas en la poesía de Raúl Gómez Jattin
Authors: Guerrero Cabrera Sonia Amparo , Escobar Arboleda Yonathan Alexander
Published: July 2023

En este trabajo se retoma la antología poética titulada Amanecer en el Valle del Sinú, del escritor colombiano Raúl Gómez Jattin, para realizar un estudio de algunos de sus poemas. Con base en el apartado Del Amor se indaga sobre los recursos lingüísticos y retóricos que los componen, profundizando en las percepciones homoeróticas y homosexuales. De igual manera, con dicho análisis se evidenciará cómo mediante las construcciones poéticas -expresivas, apelativas y representativas- de la obra, se da cuenta de una sociedad patriarcal y machista, sumida en los cánones de una tradición religiosa excluyente, que margina a la población homosexual. La nostalgia y la desesperanza de no hallar un objeto común o un estado común que sirva como medio para sentirse parte de un todo es una constante en la obra del autor; sin embargo, él también confronta lo establecido por la sociedad desde nociones como el cuerpo, los placeres, el deseo y el amor.
Poesía colombiana actual
Authors: Vega Bedoya Wilfredo Esteban
Published: July 2023

Si en 1960 G. G. Márquez pudo  trazar su desolado inventario con el devastador título: “La literatura colombiana, un fraude a la nación”, y Cobo Borda pudo realizar en 1979 su remake para el caso de la poesía,  con el no menos lapidario: “Tradición de la pobreza”, no es menos cierto que hoy, en los últimos tramos de la segunda década del siglo XXI,  valoraciones de ese tenor no resultarían tan pertinentes como aquellas lo fueron en su momento.Median casi dos décadas entre ambos inventarios  que marcan puntos fronterizos de inflexión. Justamente, en el marco de esas dos décadas se produce el arribo de nuestra literatura a su entera modernidad.
La carrera por la teoría
Authors: Christian Barbara
Published: July 2023

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La poesía de Tomás Quintero
Authors: Fajardo Fajardo Carlos
Published: July 2023

La poesía de Tomás Quintero (Santiago de Cali, Colombia, 1945- 1978) no es conocida entre la mayoría de los críticos literarios colombianos. De hecho, no ha sido publicado en ninguna antología nacional de renombre, no por falta de calidad poética, sino por el desconocimiento de su obra. En ese sentido, el siguiente artículo es un intento crítico de analizar su poesía, con el propósito de reivindicarla y sustraerla del silencio y el olvido. Para ello abordaremos los contextos poéticos, así como los cimientos temáticos, conceptuales y formales a través de los cuales Tomás Quintero construyó su poética.
Machismo se inscribe con M de mujer: La parodia como gesto de autora en la obra de Fanny Buitrago
Authors: Gutiérrez Mavesoy Aleyda
Published: July 2023

Estudiar a la escritora Fanny Buitrago desde una perspectiva feminista va más allá de indagar por su rol como mujer, implica analizar su presencia en las obras, esto es, considerar aspectos literarios y no sólo cuestiones de contenido. Para ello, se inicia con la revisión del concepto de autor. Posteriormente, se indaga por las formas literarias a las que recurre la autora para la estructuración de los relatos: el juego con los géneros atribuidos por tradición a las mujeres y su subversión paródica en la obra de esta autora. Finalmente, se realiza la comparación mediante el contraste entre las distintas construcciones del personaje femenino en sus textos. Todo ello con el fin de poder determinar las constantes en estos dos rasgos que permitan configurar un posible gesto de autora.
Violín y otras cuestiones: la apuesta por una poética comunicante
Authors: Molina Flórez Félix Manuel
Published: July 2023

Este artículo explora el primer trabajo del poeta argentino Juan Gelman. En este poemario, se evidencia la mediación de un YO poético que analiza la realidad y la lleva al plano del lenguaje, donde sufre una reestructuración estética hasta construir un discurso que exalta la cotidianidad como principal mecanismo de interacción con los otros. Violín y otras cuestiones es un poemario mayormente lírico en el que prevalece la visión permanente de un YO que expresa la visión de un sujeto que habla de sí y desde sí.
RootBot Image Scoring Instructions v1
Authors: Ruppel Mia
Published: July 2023

Instruction for scoring RootBot images.
2018-2020 Yılları Arasında Partner Şiddeti Nedeniyle Mersin Tıp Fakültesi Hastanesine Başvuran Kadın Olguların Değerlendirilmesi
Authors: Işık Hammet , Gamsız Bilgin Nursel
Published: July 2023

Objective: It is aimed to medicolegal evaluation of risk factors and to discuss in the light of literature, depending on sociodemographic data, causes of violence and physical/mental pathologies in women who were sent to the Forensic Medicine outpatient clinic with the claim of being subjected to partner violence.
Methods: The data of female cases sent between 01.01.2018 and 31.12.2020 were retrospectively scanned in terms of sociodemographic data, degree of physical violence and mental illnesses related to violence. It was evaluated using the SPSS package program.
Results: The mean age of 143 female cases was 35.8±10.7, women with low educational and economic level and unemployed were exposed to more physical violence by their partners, 88.1% were exposed to physical violence, 54.5% were injured in the facial region. Bone fractures were detected in 16.4%, and severe mental illness developed in 45.9%. In addition, it was determined that the risk of suicide attempt was high in cases who were exposed to violence for many years and were diagnosed with a violence-related mental illness.
Conclusion: It has been observed that low education and economic level, unemployment constitute a higher risk group for women to be subjected to physical violence by their partners. We believe that, together with the urgent legal regulations to prevent violence, the development of projects to increase the education level of women, create jobs and gain economic freedom will provide significant contributions and benefits to the prevention of violence.
Rozwijanie mądrości w praktyce edukacyjnej. Scenariusze zajęć dla młodzieży
Authors: Płóciennik Elżbieta
Published: July 2023

Prezentowana publikacja stanowi praktyczny przewodnik metodyczny dla nauczycieli gimnazjów i liceów zakresie rozwijania mądrości dzieci. Kolejny tom po publikacji dla przedszkoli i szkół podstawowych. W książce zaprezentowano syntetycznie koncepcję edukacji dla mądrości oraz dostarczono nauczycielom konkretnych narzędzi do wykorzystania w pracy edukacyjnej i wychowawczej z młodzieżą w postaci ćwiczeń proponowanych w codziennych sytuacjach edukacyjnych oraz scenariuszy zajęć. Ćwiczenia i scenariusze służą: doskonaleniu kompetencji nauczycieli i wychowawców, wyzwalaniu aktywności i refleksyjności; praktycznemu przygotowaniu ucznia do życia; wsparciu w procesie dojrzewania do samodzielności; autorefleksji, samopoznaniu, podejmowaniu wyborów również odnośnie do przyszłej drogi zawodowej; integracji; profilaktyce negatywnych zjawisk w środowisku rówieśniczym uczniów; terapii nacechowanych agresją oraz negatywnymi emocjami relacji i modyfikowaniu pracy szkoły w kierunku właściwego realizowania funkcji wychowawczej i edukacyjnej.