bluuebunny/crossref_metadata_2025 huggingface dataset:
Resveratrol rescues cutaneous radiation-induced DNA damage via a novel AMPK/SIRT7/HMGB1 regulatory axis
Authors: Jin Yi , Liu Xingyuan , Liang Xiaoting , Liu Jiabin , Liu Jieyu , Han Zonglin , Lu Qianxin , Wang Ke , Meng Bingyao , Zhang Chunting , Xu Minna , Guan Jian , Ma Li , Zhou Liang
Published: January 2023

Cutaneous radiation injury (CRI) interrupts the scheduled process of radiotherapy and even compromises the life quality of patients. However, the current clinical options for alleviating CRI are relatively limited. Resveratrol (RSV) has been shown to be a promising protective agent against CRI; yet the mechanisms of RSV enhancing radioresistance were not fully elucidated and limited its clinical application. In this study, we demonstrate RSV promotes cutaneous radioresistance mainly through SIRT7. During ionizing radiation (IR) treatment, RSV indirectly phosphorylates and activates SIRT7 through AMPK, which is critical for maintaining the genome stability of keratinocytes. Immunoprecipitation and mass spectrometry identified HMGB1 to be the key interacting partner of SIRT7 to mediate the radioprotective function of RSV. Mechanistic study elucidated that SIRT7 interacts with and deacetylates HMGB1 to redistribute it into nucleus and “switch on” its function for DNA damage repair. Our findings establish a novel AMPK/SIRT7/HMGB1 regulatory axis that mediates the radioprotective function of RSV to alleviate IR-induced cutaneous DNA injury, providing an efficiently-curative option for patients with CRI during radiotherapy.
The early universe in a quantum gas
Authors: Miller Johanna L.
Published: January 2023

With a Bose–Einstein condensate in a magnetic field, researchers see hints of particle production and cosmic sound waves—and they can run the experiment more than once.
Extraintestinal pathogenic Escherichia coli (ExPEC) reservoirs, and antibiotics resistance trends: a one-health surveillance for risk analysis from “farm-to-fork”
Authors: Meena Prem Raj , Priyanka Priyanka , Singh Arvind Pratap
Published: January 2023

Extraintestinal pathogenic Escherichia coli (ExPEC) associated infections are significant health concerns for both animals and humans. ExPEC strains are associated with various infections in humans, i.e. urinary tract infections, meningitis, septicemia, and other infections. Over the few years, several studies revealed, food animals act as a reservoir for ExPEC pathovars, but there is no information about the agricultural sector. In particular, the extensive use of antibiotics in food animals and agricultural settings could be significantly contributed to the emergence of antibiotic-resistant pathogens. However, global outbreaks of food-borne illnesses from contaminated food have made a significant concern for both public health and food safety. This review focuses on the reservoirs for ExPEC and their potential circulation between animals, humans, and environment. In this, we first report that the agricultural setting could be the reservoir of ExPEC and can play a role in disseminating antimicrobial-resistant ExPEC. A thorough understanding of ExPEC ecology, reservoirs, and transmission dynamics can significantly contribute to reducing the burden of ExPEC-associated infections. Overall, the study provides the important data on the current state of knowledge for different reservoirs with dynamic, dissemination, and transmission of antimicrobial-resistance ExPEC in animals, humans, and environment in the “One-Health” context.
Bacterial species-specific antimicrobial efficacies of three different body embalming solutions for anatomical studies
Authors: Lindenberg Marc , Buchhorn Andreas , Reineke Christiane , Vonberg Ralf-Peter , Schmiedl Andreas
Published: January 2023

While body decompensation is mainly facilitated by bacteria, investigating the antimicrobial properties of body preservation methods is still a neglected research area. We performed microbiological sampling for potentially pathogenic bacteria species of brain, lung, liver, colon, and subcutis samples obtained from bodies perfused with embalming solutions of variable composition with emphasis on variable formaldehyde concentrations. We, thereby, identified spore-forming aerobic and anaerobic bacteria mainly in the samples obtained from the colon of ethanol- and lower-concentrated formaldehyde formulation embalmed bodies. Moreover, we could identify Enterococcus species in bodies preserved with the latter method. Tissue samples of the subcutis remained sterile. Long-term incubation of special mycobacteria growth indicator tubes revealed no growth of mycobacteria in all 60 samples analyzed. Overall, we show survival of bacterial genera known to be especially environmentally resistant but also include potentially pathogenic members. Knowledge of bactericidal capacities of embalming solutions are therefore critical to assess risk and apply appropriate disinfection routines while working with human bodies. Moreover, new formulations to reduce potentially toxic substances for embalming needs to be evaluated regarding their bactericidal capacities.
Efficient conversion of rebaudioside C to steviol by Paenarthrobacter ilicis CR5301
Authors: Li Hongfei , Sun Daqing , Cao Longkui , Wang Baohui
Published: January 2023

To improve the conversion efficiency of rebaudioside C, this study screened the Paenarthrobacter ilicis CR5301 from soil samples and identified it by 16S rRNA. The conversion experiment proved that P. ilicis CR5301 was capable of converting rebaudioside C. The effects of initial pH, temperature, inoculation amount, and substrate concentration on rebaudioside C conversion rate were investigated. The results showed that the conversion rate of rebaudioside C reached up to 100% when CR5301 was incubated in a conversion medium with an initial pH of 7.0 for 8 h at 28°C and 270 rpm. The conversion time was reduced by at least 16 h compared with previous studies. The conversion product was analyzed and identified as steviol by high performance liquid chromatography, ultra performance liquid chromatography-triple-time of flight mass spectrometer, and Fourier transform infrared spectroscopy methods. In addition, stevioside, rebaudioside A, dulcoside A, and some unknown components in steviol glycosides byproduct were all efficiently converted to steviol. These findings provide an efficient approach to the conversion of rebaudioside C and byproduct to steviol to simplify the subsequent industrial process and improve the reuse value of steviol glycosides.
Hot off the press: SGEM#383: Tommy can you hear me—Deaf and hard‐of‐hearing patients in the ED
Authors: Heitz Corey , Challen Kirsty , Milne William K.
Published: January 2023

Patients who are deaf and hard of hearing may have difficulty accessing healthcare resources when compared with non‐deaf or hard of hearing patients. Little research has been performed investigating in what ways these difficulties manifest. This article summarizes the podcast and blog discussing the manuscript by James et al. in which deaf and hard of hearing patients are compared to non‐deaf and hard of hearing patients when it comes to acuity, length of stay, and emergency department revisits. Social media commentary is included.
A Persistent Route Diversification Mechanism for Defending against Stealthy Crossfire Attack
Authors: Zhou Boyang , Wu Chunming , Yang Qiang , Chen Xiang , Zhang Dong
Published: January 2023

Computer networks are facing the challenge of stealthy crossfire attacks that flood through persistent routes (PRs) towards their decoys at a low rate for disrupting end-to-end connectivity of the target. At first, the PRs can be stealthily probed at the initial stage of the attack. Later, some undefended and vulnerable PRs can be speculated at the renaissance stage of the attack, which yet remains unconcerned. To achieve an effective defense against the two-stage attacks, this paper investigates a new persistent route diversification defense (PRDD) mechanism to mitigate each identified PR under the attacks. The PRDD effectively stops the flooding on the PRs to mitigate their congestion. Meanwhile, it makes the adversary unable to probe or speculate the PRs under their corresponding attack stages. Thus, it disables every flooding choice for the adversary, avoiding the attacks. The PRDD is designed with scalable algorithmic complexity in computation and overhead. The PRDD is extensively assessed using NS-3 and Mininet, and the results show the following. (a) It is more effective in mitigating more attacked PRs compared with the existing solutions. (b) The defense performance of the PRDD remains highly scalable in computation, while maintaining an acceptable overhead.
Neuropsychiatric Alterations in a Patient Diagnosed with Advanced Korsakoff’s Syndrome: Clinical Case of Low Incidence and Prevalence in Colombia
Authors: Alberto Hurtado Gonzalez Carlos , Ospina Otalvaro Sebastian , Marmolejo Escobar Carlos Steven , Quebrada Mera Karen Julieth , Arango de la Pava Pablo Miguel , Clavijo Carlos Andres , Ortega Bolaños Lucely , Rátiva Hernández Narda , Vidal Rosero Angelica Maria , Gutierrez Lenis Paola Andrea , Lucumí Armando , Cappellaro Sánchez Jean Paul , Zamorano Angela Agudelo , Jacome Juan Pablo , Herrera Montoya Valentina , Saldarriaga Luis Miguel , Prado Salcedo Carolina , Alvarado Carranza Sharon Fabiana , Marín Hoyos Carlos Andres , Beltran Alomia Juan Pablo , Ayala Rico Juan Felipe , Torres Colorado Luigui Andres , Arias Díaz Julia Andrea
Published: January 2023

Korsakoff’s syndrome (KS) is an insidious and progressive neuropsychiatric disorder that affects specific neurocognitive functioning, especially in tasks that require sustained attention, memory, executive functions, and visuospatial functioning. Usually, this disease generates neuropsychiatric complications that worsen the quality of life (QOL) of patients in the medium term. We present a case of a 63-year-old male who presented with a diagnosis of advanced Korsakoff’s syndrome and has a clinical history of recurrent memory loss and a history of alcohol abuse. The patient showed difficulty manipulating immediate information, associated with a possible frontal lobe dysfunction, and inability to remember material given through the auditory pathway. The patient showed a psychiatric clinical picture which is constantly worsening his and his immediate caregiver’s QOL. The data obtained demonstrate that the patient presents a progressive cognitive impairment, which in the short term is correlated with Korsakoff-type dementia. It is suggested to carry out functional neurorehabilitation plans aimed at improving the QOL of the patient, his immediate caregiver, and future people with this type of diagnosis.
Transition of cluster headache phenotype: An interview-based study
Authors: Søborg Marie-Louise Kulas , Petersen Anja Sofie , Lund Nunu , Wandall-Holm Malthe Faurschou , Jensen Rigmor Højland , Barloese Mads
Published: January 2023

Background Cluster headache exists diagnostically in a chronic and episodic variant between which patients can convert. We aimed to describe how many patients change phenotype, elucidate possible factors associated with this transition and identify differences in clinical features between primary and secondary phenotypes.

Methods 540 well-defined cluster headache patients according to current ICHD-criteria completed a cross-sectional semi-structured interview.

Results Total transition-incidence for the cohort was 20.7%. Conversion from chronic to episodic was reported by 6.3% and transition from episodic to chronic by 14.4% with attack side shift as a possible predictor (p = 0.007). Compared to primary chronic patients, secondary chronic patients had more frequent (60 vs 34 per month, p = 0.0487), but shorter (60 vs 90 minutes, p = 0.041) attacks. Secondary episodic patients experienced shorter remission periods than primary episodic patients (6 vs 11 months, p = 0.010). Treatment response was poor in all groups and only one third had effective prevention.

Conclusion Cluster headache is a fluctuating disorder with a fifth of our cohort having experienced at least one phenotype change during course of disease. Apart from attack side shifts, no predictors for transition were identified. Severity differed between primary and secondary subtypes. Overall, there is an urgent need for better understanding of cluster headache.
Screening of Pancreatic Lipase Inhibitors of Endophytic Fungi of Medicinal Plants in Uzbekistan
Authors: Gulyamova T.G. , D. M Ruzieva , M Yoldosheva , G. A Rasulova , K. V Kondrasheva
Published: January 2023

Search for pancreatic lipase (PL) inhibitors is essential for obesity and associated chronic disease therapy. PL inhibitors significantly reduce enzyme activity and prevent the absorption and hydrolysis of triglycerides into free fatty acids. This study provides new evidence of screening PL inhibitory activity of 15 endophytic fungi from 6 medicinal plants in Uzbekistan. In general, the extracts of almost all twelve endophytes exposed the inhibitory potential, but only five of them had inhibition levels above 50%. The highest inhibitory activity, amounting to 73.7% and 65.2%, and comparable to the activity of Xenical as a standard, was established for Fusarium sp.-AL142R and F.sambucinum - AL135L, respectively, isolated from the endemic plant Allium longicuspis. The values of IC50 inhibitory activity are 20.7 and 8.01, respectively, compared with Xenical as a standard with IC50 20.6 μg/ml. The inhibitory extracts of both endophytes contain alkaloids, terpenoids, flavonoids, and tannins. The data obtained for the first time indicate the potential of Uzbekistan plant endophytes as possible sources of PL inhibitors
Spiral Resonator Arrays for Misalignment Compensation in Wireless Power Transfer Systems
Authors: Fontana Nunzia , Barmada Sami , Raugi Marco , Brizi Danilo , Monorchio Agostino
Published: January 2023

In this contribution, the authors focus on the use of a metasurface (physically implemented as a 2D array of spiral resonators) as an additional component of a two-coil Wireless Power Transfer (WPT) system, with the aim of increasing the robustness to misalignment between the transmitter and the receiver coils. Resonator arrays have been proven to have a positive effect on WPT systems’ performance since they produce a focusing effect on the magnetic field; at the same time, they contribute to the reduction of the electric near field. In addition, we herein demonstrate how proper control over the metasurface’s unit cells can contribute to making a WPT system more tolerant to misalignment. In particular, the comparison between metasurfaces of different sizes (keeping the same transmitting and receiving coils) and their optimization performed to improve misalignment robustness is proved by numerical simulations.
Comparative Effects and Safety of Full-Endoscopic Versus Microscopic Spinal Decompression for Lumbar Spinal Stenosis: A Meta-Analysis and Statistical Power Analysis of 6 Randomized Controlled Trials
Authors: Yang Zechuan , Wang Huan , Li Wenkai , Hu Weihua
Published: January 2023

Objective: This meta-analysis with statistical power analysis aimed to evaluate the difference between full-endoscopic and microscopic spinal decompression in treating spinal stenosis.Methods: We searched PubMed, Embase, CENTRAL (Cochrane Central Register of Controlled Trials), and CNKI (China National Knowledge Infrastructure) for relevant randomized controlled trials (RCTs) regarding the comparison of full-endoscopic versus microscopic spinal decompression in treating lumbar spinal stenosis through February 28, 2022. Two independent investigators selected studies, extracted information, and appraised methodological quality. Meta-analysis was conducted using RevMan 5.4 and STATA 14.0, and statistical power analysis was performed using G*Power 3.1.Results: Six RCTs involving 646 patients met selection criteria. Meta-analysis suggested that, compared with microscopic decompression, full-endoscopic spinal decompression achieved more leg pain improvement (mean difference [MD], -0.20; 95% confidence interval [CI], -0.30 to -0.10; p = 0.001), shortened operative time (MD, -12.71; 95% CI, -18.27 to -7.15; p < 0.001), and decreased the incidence of complications (risk ratio, 0.43; 95% CI, 0.22–0.82; p = 0.01), which was supported by a statistical power of 98.57%, 99.97%, and 81.88%, respectively.Conclusion: Full-endoscopic spinal decompression is a better treatment for lumbar spinal stenosis, showing more effective leg pain improvement, shorter operative time, and fewer complications than microscopic decompression.
Generation of High-Resolution Orthomosaics from Historical Aerial Photographs Using Structure-from-Motion and Lidar Data
Authors: Suh Ji Won , Ouimet William
Published: January 2023

This study presents a method to generate historical orthomosaics using Structure-from-Motion (SfM ) photogrammetry, historical aerial photographs, and lidar data, and then analyzes the horizontal accuracy and factors that can affect the quality of historical orthoimagery products made with these approaches. Two sets of historical aerial photographs (1934 and 1951) were analyzed, focused on the town of Woodstock in Connecticut, U.S.A. Ground control points (GCPs) for georeferencing were obtained by overlaying multiple data sets, including lidar elevation data and derivative hillshades, and recent orthoimagery. Root-Mean-Square Error values of check points (CPs ) for 1934 and 1951 orthomosaics without extreme outliers are 0.83 m and 1.37 m, respectively. Results indicate that orthomosaics can be used for standard mapping and geographic information systems (GIS ) work according to the ASPRS 1990 accuracy standard. In addition, results emphasize that three main factors can affect the horizontal accuracy of orthomosaics: (1) types of CPs, (2) the number of tied photos, and (3) terrain.
Örgütsel Politika Algısı ve İşten Ayrılma Niyeti Arasındaki İlişki: Örgütsel Yalnızlığın Aracılık Etkisi
Authors: KAYIŞ Ali , AKSOY KÜRÜ Seval
Published: January 2023

Bu çalışmada öğretmenlerin örgütsel politika algısı ile örgütsel yalnızlık ve işten ayrılma niyetleri arasındaki ilişkinin
tespit edilmesi amaçlanmaktadır. Araştırmada ilişkisel tarama modeli kullanılmıştır. Araştırmanın örneklemini, 2018-
2019 eğitim-öğretim yılında İstanbul ili Kadıköy ilçesinde bulunan ortaokullarda görev yapmakta olan toplam 439
öğretmen oluşturmaktadır. Araştırmanın verilerinin toplanmasında Örgütsel Politika Algısı, Örgütsel Yalnızlık ve İşten
Ayrılma Niyeti ölçekleri kullanılmıştır. Yapısal eşitlik modellemesi sonuçlarına göre; örgütsel politika algısı, örgütsel
yalnızlığı oluşturan boyutlardan sosyal arkadaşlığı negatif yönde, duygusal yoksunluğu ise pozitif yönde etkilemektedir.
Örgütsel politika algısı, aynı zamanda öğretmenlerin işten ayrılma niyetlerini de olumlu yönde etkilemektedir. Örgütsel
yalnızlığın bu iki boyutu, örgütsel politika algısı ile işten ayrılma niyeti arasındaki ilişkide tam aracılık rolü oynamaktadır.
Risk analysis of gold processing in artisanal and small-scale gold mining in Bolaang Mongondow Regency, North Sulawesi, Indonesia
Authors: Sapulete Margareth Rosalinda , Effendi Hefni , Riani Etty , Machfud Machfud
Published: January 2023

Gold processing at artisanal and small-scale gold mining (ASGM) in Indonesia is inherently risky due to the high severity and likelihood of accidents causing serious injury. The objectives of this study were to identify hazards, assess risks, and determine risk control measures in the ASGM location at Imandi Village, East Dumoga District, Bolaang Mongondow Regency, North Sulawesi Province. The method used was Hazard Identification Risk Assessment and Risk Control (HIRARC). The determination of work stages and identification of hazards was carried out through observation at 14 ASGM units and interviews with 14 informants consisting of 6 mining workers and 8 ASGM business owners. The risk assessment was carried out by observing and interviewing 8 experts as informants selected from health and environmental scientists, various offices of the Government Bolaang Mongondow Regency, and non-government institutions. The results showed that the stage of gold processing work in ASGM consists of 13 sources of hazards that can pose 16 risks. The obtained risk assessment results showed that 19% were low risk, 31% moderate risk, 25% high risk, and 25% very high risk caused by exposure to mercury through the gold ore burning process with a risk value of 25. The identified risk control measures were PPE (personal protective equipment) 43%, administrative controls 14%, engineering controls 14%, substitution 21%, and elimination 7%. Realistic risk controls that can be applied in ASGM are a combination of administrative controls and PPE.
The quality of acid soils treated with seaweed (Kappapychus alvarezii) sap enriched biochar from Southeast Sulawesi, Indonesia
Authors: Kilowasid Laode Muhammad Harjoni , Manik Dwita Siniona , Nevianti Nevianti , Komang Gusti Arya , Mutmainna Puja , Afa La Ode , Rakian Tresjia Corina , Hisein Waode Siti Anima , Ramadhan La Ode Ahmad Nur , Alam Syamsu
Published: January 2023

Biochar enriched with fertilizers has the potential to improve the quality of acid soils. In the agricultural sector, it was reported that the sap of Kappapychus alvarezii (K-sap) is often used as a biofertilizer. Therefore, this study aimed to (i) examine the character of biochar enriched with the K-sap and (ii) analyze the soil quality after incubation. This study was carried out using two treatment factors arranged in a randomized block design, namely the biochar dose at 0%, 2.5%, 5.0%, and 7.5% in weight and K-sap at concentrations of 0%, 5%, 10%, and 15%.  Ten kilograms of acid soil were incubated with K-sap enriched biochar for up to 2 weeks in each experimental pot. The results showed that the absorption band increased with the K-sap concentration for the functional group associated with the OH-stretching of the biochar enriched with K-sap was stronger and wider than the unenriched. The peak elevation pattern detected by X-ray diffraction for all biochars was similar. The dosage of 7.5% biochar enriched with 5%-10% K-sap concentrations increased pH, EC, organic C, total N, C:N ratio, available P, and exchangeable K, Ca, Mg, and Si than those without treatment. Furthermore, ammonium and total spores of arbuscular mycorrhizal fungi decreased, flagellates increased with and without the biochar, while the nitrate, total bacteria, and fungi of all treatments were similar. Based on these results, it was concluded that biochar enriched with K-sap could improve the quality of acid soil.
A technology package to improve growth and yield of sweet sorghum in ex-coal mining land, East Kalimantan, Indonesia
Authors: Munawwarah Tarbiyatul , Sulaeman Yiyi
Published: January 2023

Huge ex-coal mining land provides the soil for crop development, yet soil improvement is required. Fertilizer and soil organic matter application and liming are standard practices to improve soil productivity. The integrated crop and land management (ICLM) package offers alternative technology to increase growth and crop yield. This study aimed to evaluate an ICLM technological package to improve sweet sorghum growth and production in the ex-coal mining land. The sweet sorghum of Bioguma 1 Agritan variety was used as the indicator crop. The ICLM was composed of mixed organic fertilizers (1,000 kg granule organic fertilizer ha-1, 10 kg Procal soil amendment ha-1, 10 kg Kayabio biofertilizer ha-1, and 5 kg NPK fertilizer    ha-1), mixed inorganic fertilizers (300 kg NPK ha-1, 50 kg Urea ha-1, 10 kg Procal soil amendment ha-1, and 10 kg Kayabio biofertilizer ha-1), and local bio-activators. The field trial used a group-randomized design with four frequencies of bio-activator application and five replications. Mixed organic fertilizer was used to cover the planting holes, where previously, the seed was soaked by a bio-activator and put into holes. The mixed fertilizer was applied to a 14-day-old plant using the hole punch method (tugal). Results of this study showed that local bio-activator significantly affected the sorghum growth and yield. The best frequency of bio-activator application was three times spraying. ICLM are prospective technology to improve soil condition, crop growth, and crop yield in ex-coal mining land.
Ethics and Integrity in a Public Sector Organisation in Malaysia: An Assessment of Understanding and Perception of the Employees
Authors: Wook Izawati , Haron Hasnah , Rosli Shaari Rosli Shaari , Abd Ghani Zulkiple , Mohad Abd Hakim , Md Yusof Arif Fahmi
Published: January 2023

The formation of quality work culture in the organization will only be achieved if employees practice a comprehensive and positive work ethic and integrity. In order to improve the level of ethics and integrity, the focus should be on overall improvement in the organization not only at the grassroots but all up to the top level. Comprehensive involvement of all parties will significantly improve the integrity of the organization. Recognizing the importance of integrity as the core of quality staff development and higher organizational performance, this study is expected to help the public sector organization plan strategies to achieve a higher level of ethics and integrity. The corporate Integrity Assessment Questionnaire (CIAQ) was used to measure the implementation of the integrity system in a public sector organization. The questionnaires were distributed to 850 employees at the agency via e-survey. It was found that the level of ethics and integrity of the agency is at 74%.  “Vision and goals” dimension shows the highest score which shows that the organization has given attention to ethics and integrity through its approach to ethics and integrity in the organization, including, its formal articulation of the underlying philosophy about ethical and moral conduct embedded by the organization. The lowest score of the “disciplinary action and reward” dimension indicates that the public sector organization needs to relook policies and guidelines for discipline and reward so that it is in line with best practice. Thus, the public sector organization needs to provide rewards and incentives to encourage ethical conduct and implement strict disciplinary action to punish unethical work conduct improve in terms of ethical communication, work culture, infrastructure, training and ethics education, discipline, and reward.
Utilising Causal Loop Diagram to Explore Public Integrity for Effective COVID-19 Preventive Measures in Malaysia
Authors: Cheng Jack Kie , Muhamad Tamyez Puteri Fadzline , Mohamad Fazeeda , Kamaruzzaman Zetty Ain , Zulkipli Faridah , Mohd Zainudin Maizura
Published: January 2023

COVID-19 creates an unprecedented crisis in our lifetimes.  The escalating rates of COVID-19 infection brings calamity to many parts of the world.  Malaysia has been in a fierce battle with COVID-19 since March 2020 but the endgame is still obscure.  Since the beginning of the pandemic, many preventive measures are implemented by the Malaysian government.  Some of the strategies such as lockdown and movement restrictions are effective in flattening the curve of COVID-19.  However, over a period of time, negative unintended consequences such as pandemic fatigue emerged due to prolong confinement.  Lockdown is also an expensive measure that impacts the community livelihood and subsequently risking Malaysia’s economy.  After two years of the pandemic, with the success of COVID-19 vaccination programme, Malaysia may be ready to return to normalcy.  However, the world is alarmed with new deadly COVID-19 variant which puts Malaysia in constant risk of resurge of cases.  This paper aims to understand how implemented preventive measures interacted with each other and collectively influence the spread of COVID-19 in Malaysia.  Only by understanding these interaction, more effective, economical and sustainable counter measures that safe lives without compromising people livelihood can be introduced.  The causal loop diagram, an essence of system dynamics is developed to capture these interconnections and provide meaningful insights.  The role of community and public integrity are also observed in this study.
Determinants of National Digital Identity Verification Platform Acceptance Among Young Investors in Malaysia
Authors: Manogaran Pavitira , Teoh Ai Ping
Published: January 2023

This study aims to investigate the determinants of NDIV platform acceptance among young investors in Malaysia within the context of protection motivation theory and uncertainty reduction theory. The study proposed a conceptual model comprising five hypotheses tested using structural equation modelling-partial least squares. Data was collected through an online questionnaire survey from 361 young investors in Malaysia. The results show that acceptance of the NDIV platform is directly influenced by perceived severity, response efficacy, self-efficacy, and transparency. This study extended the protection motivation theory by incorporating uncertainty reduction theory to strengthen the predictions of NDIV platform acceptance among young investors in Malaysia. The study brought meaning by filling the theoretical, empirical, and methodological gaps in the body of knowledge.  This research contributes to the administrators, regulators, industry practitioners, and government to improve the platforms' strategies and increase citizen engagement conclusions.
Lithuanian Language and Literature Program – a Medium for Deep Reading Education
Authors: Šileris Arūnas
Published: January 2023

Researchers have been observing the deteriorating deep reading skills among pupils and highlighting the necessity to nurture them. Yet the concept of what ‘reading’ means (and ‘deep reading’ in particular) seems elusive. Deep reading may be interpreted in a number of ways. The difference in the notion of what constitutes deep reading calls for a closer investigation, with the view to delineating the two concepts. By drawing on the theoretical framework of Self-Determination Theory and Transportation theory, the article analyses two different approaches to deep reading in the light of a the recent draft curriculum of the Lithuanian language and literature for grades 5–12 of high school in Lithuania. The analysis has revealed that the current draft seems to be less focused on promoting the first type of deep reading associated with the deep emotional engagement (and hence higher levels of internal motivation) with literary texts. It is rather focused on the second type of deep reading that seeks to engage cognitive processes (and is more related to external motivation). Irrespective of the fact that the draft curriculum does make references to concepts associated with deep emotional involvement of readers (such as the pleasure of reading), this type of deep reading is not the main focus of the new curriculum.
Quiste óseo aneurismático vertebral agresivo: presentación de un caso y revisión bibliográfica
Authors: Baigorria José Francisco , Besse Micaela , Rosado Pardo José Antonio , Steverlynck Alejandro , Sarotto Aníbal José
Published: January 2023

Introducción: El quiste óseo aneurismático es una lesión seudotumoral lítica, expansiva, compuesta por espacios llenos de sangre separados por tabiques. Representa el 15% de los tumores primarios en la columna, y su presentación de comportamiento agresivo es aún más infrecuente. Se han descrito diferentes opciones terapéuticas en función de su estadio y tasa de recurrencia. Presentamos a un paciente con compromiso neurológico secundario a un quiste óseo aneurismático en la columna torácica, decomportamiento agresivo, que requirió resolución quirúrgica.

Conclusión: Las opciones de tratamiento del quiste óseo aneurismático se deben adecuar a cada caso en particular, según sus características.

Nivel de Evidencia: IV
Protocolo multimodal farmacológico perioperatorio para la cirugía de columna en pediatría
Authors: Piantoni Lucas , Tello Carlos A. , Remondino Rodrigo G. , Galaretto Eduardo , Noel Mariano A.
Published: January 2023

Introducción: La cirugía de columna es uno de los procedimientos con mayor morbimortalidad dentro de la población pediátrica; el manejo farmacológico del dolor en dicha población aún no se encuentra estandarizado. La analgesia multimodal trata de responder a esta problemática.
Objetivo: Sobre la base de una revisión sistemática de la bibliografía, desarrollar un detallado protocolomultimodal farmacológico para el manejo del dolor pre- y posoperatorio intra/extrahospitalario para la cirugía de columna en niños.
Materiales y Métodos: Se realizó una revisión sistemática de textos completos en inglés o español en PubMed, Embase, Cochrane Library y LILACS Database publicados entre 2000 y 2021; se aplicó el diagrama de flujo PRISMA.
Resultados: De 756 artículos preseleccionados, 38 fueron incluidos en la evaluación final. Dada la dificultad bioética de desarrollar trabajos en formato de ensayos clínicos con fármacos y combinaciones de ellos en la población pediátrica, desarrollamos un protocolo detallado de manejo del dolor pre- y posoperatorio por vía intravenosa/oral, intra- y extrahospitalario, para aplicar en niños sometidos a cirugía de columna.
Conclusión: Logramos desarrollar un detallado protocolo multimodal farmacológico para el perioperatorio intra- y extrahospitalario de cirugía de columna en niños, sencillo y reproducible, tendiente a acelerar la recuperación funcional del paciente y disminuir los costos socioeconómicos globales.Nivel de Evidencia: II
The interaction between language usage and acoustic correlates of the Kuy register distinction
Authors: Lau-Preechathammarach Raksit Tyler
Published: January 2023

Contact is often cited as an explanation for the convergence of areal features and has been proposed as an explanation for the emergence of tonal languages in Mainland Southeast Asia. The current production study probes this hypothesis by exploring the relationship between tonal language usage and the acoustic correlates of the register distinction in Kuy, a Katuic language, as spoken in a quadrilingual (Kuy, Thai, Lao, Khmer) Kuy community in Northeast Thailand. The results demonstrate greater persistence of fundamental frequency (f0) differences over the course of the vowel alongside more tonal language experience for male speakers; however, analysis of individual differences finds that H1*−H2*, a correlate of voice quality, is the primary cue for male speakers with greater tonal language experience. For female speakers, a tradeoff is found between f0 and voice quality cues alongside tonal language experience at both the group and individual levels. These findings provide evidence for a model by which contact may serve to enhance existing, non-primary cues in a phonological contrast by shifting cue distributions, thereby increasing the likelihood that these cues will come to be perceived as prominent and phonologized.
Analysis of regenerative braking efficiency in an electric vehicle through experimental tests
Authors: Valladolid Juan , Calle Mauricio , Guiracocha Angel
Published: January 2023

This paper presents a regenerative braking analysis of efficiency in real driving conditions and different road geographies. Factors affecting or benefiting energy recovery were identified, these are: the weight of the vehicle, torque, speed, inclination of road, and braking time; however, the sport and Eco driving modes were not considered because the same driving pace was chosen for the different routes. These results are intended to collaborate with real energy regeneration data and help investigators, academics, and automotive engineering, improving this system's efficiency. In the driving process, the state of charge (SOC), speed, torques, and road geography effect the efficiency of regenerative braking, as driving a vehicle on a road with irregular geography exposes it to aggressive physical factors, which considerably reduces its energy autonomy. The main aspects of recovery and regenerative braking efficiency were determined through quantitative data analysis, resulting in experimental surfaces and curves, which present the performance of current and deceleration during vehicle braking. Thus, it is shown that the energy recovery during braking is 78% considering the low autonomy of the electric vehicle.
Evincing Offence: How Digital Forensics Turns Big Data into Evidence for Policing Sexual Abuse
Authors: Rappert Brian , Wilson-Kovacs Dana , Wheat Hannah , Leonelli Sabina
Published: January 2023

A reader can expect the abstract, paper and keywords to discuss descriptions of evidence, classification schema, seizure rules and more generally the data frictions, constraints and limitations associated with the processing of digital forensic evidence involving children in England.

The widespread availability and use of digital devices both enables criminal acts and helps to detect them. The production and circulation of indecent images of children has been one area of crime that has transformed in recent years because of developments in modern communication technologies. Through in-depth ethnographic observations and qualitative interviews with four police forces in England, this article examines the resources and labor required to turn digital footprints into evidence for the possession of indecent images. In doing so, our aim is twofold. One, we detail the formal and informal processes whereby large sets of data become discrete pieces of judicial evidence. A notable feature of these administrative and technical processes is that while criminal justice agencies often strive for linear investigations, such aspirations fail to acknowledge the messy interrelation of expertise and roles that underpin the transformation of digital devices into evidence. As a second aim, we seek to identify similarities and differences in the practices whereby evidence is constructed between digital and other areas of forensics. In particular, this analysis raises questions around the descriptive and normative adequacies of prevalent theories of objectivity for digital forensics.
Yenidoğanlarda seftriakson kullanımının yan etkilerinin değerlendirilmesi
Authors: AKÇALI Mustafa , ŞİMŞEK Hüseyin , ÖZLÜ Ferda , YAPICIOĞLU Hacer , SATAR Mehmet
Published: January 2023

Amaç: Seftriakson yan etkileri nedeniyle yenidoğanda sınırlı kullanıma sahiptir. Yenidoğan enfeksiyonlarında kullanımı ile ilgili sınırlı sayıda çalışma vardır. Bu çalışma ile setriakson alan yenidoğanlarda seftriakson sonrası oluşabilecek yan etkilerin değerlendirilmesi amaçlanmıştır.

Gereç ve Yöntem: Çukurova Üniversitesi Tıp Fakültesi Balcalı Hastanesi Yenidoğan Yoğun Bakım Ünitesi’nde, 2015-2016 yılları arasında yatan bebeklerin seftriakson tedavisi öncesi ve sonrası klinik ve laboratuvar verileri retrospektif olarak incelenmiştir.

Bulgular: Çalışmaya 30 olgu alınmıştır. Bu bebeklerin ortalama gebelik yaşı 37 ± 3,1 (30-41) hafta, seftriakson aldığı süre 7,2 ± 2,2 (2-12) gün bulunmuştur. 30 olgudan alınan idrar kültürlerinde; 17 (%56,6) bebekte üreme saptanmıştır. Bunların 11’inde (%36,6) Escherischia coli (E. coli), 5’inde (%16,7) diğer bakteriler üremiştir. Olguların seftriakson öncesi ve sonrası laboratuvar verilerinde kan üre azotu (BUN), total bilirubin (TB) ve hematokrit değerlerinde anlamlı düşüş saptanmıştır. Seftriakson kullanımına bağlı herhangi bir yan etki izlenmemiştir.

Sonuç: Çalışmamızda seftriakson sonrası komplikasyon görülmemiş olması term veya terme yakın yenidoğanlarda seftriakson kullanımı için cesaret verici olabilir. Fakat, yenidoğanda seftriaksonun yan etkilerinin ve sıklıklarının kesinleştirilmesi ve yenidoğanda kullanılan diğer antibiyotiklere karşı alternatif olup olamayacağının belirlenmesi için daha fazla araştırmalara ihtiyaç vardır.
Two diseases that mimic each other: Behçet disease and sarcoidosis
Authors: TORUN Bekir , OKYAR Burak , OKTEM Esen Saba , YILDIZ Fatih , YILDIRIM ÇETİN Gözde
Published: January 2023

Behçet syndrome(BS), also known as Behçet disease (BD), is characterized by recurrent oral aphthae and any of several systemic manifestations including genital aphthae, ocular disease, skin lesions, gastrointestinal involvement, neurologic disease, vascular disease or arthritis. Sarcoidosis is a multisystem granulomatous disorder of unknown etiology that affects individuals worldwide and is characterized pathologically by the presence of noncaseating granulomas in involved organs. BD may be confused with sarcoidosis because they are both multisystem inflammatory disorders presenting with uveitis, polyarthritis, meningitis, cardiovascular disease, erythema nodosum, and other cutaneous lesions, and abnormal chest radiographs.
Type 2 diabetes and atrial fibrillation could cause transient ischemic attack
Authors: GOKDEMIR Ozden , BULUT BATUR Ülkü , GÜRKAN Anıl
Published: January 2023

Diabetes mellitus (DM) is still one of the common chronic problems not only in rural but also the urban cities. While the regulation of blood sugar metabolism is one of the target points, living with DM can trammel primary care physicians.

64 years old female patient who was diagnosed with DM and hypertension for at least 5 years has attended the surgery for nuisance and dysuria. Bacteriuria has detected and blood sugar was 550 mg/dl WBC= 12,48 CRP: 7 HbA1C: 10,4 % Her neurologic examination was normal except she has got urinary incontinence. She was hospitalized with a diagnosis of DM, HT, and cystitis. Metformin 2x1gr, 1x 40 mg, ceftriaxone 2x1gr, and insulin glargine were ordered. Diabetic patient education has been performed. During follow-up, her blood sugar regulation has been settled but she complained of palpitation, ECG has been performed and diagnosed as AF (atrial fibrillation). Her blood pressure was 120/80 and metoprolol infusion was made. INR: 1,44 sec PT=17sn creatine=0,9 mg/dl. Control ECG was at sinus rhythm. While she was in time of recovery, internal medicine consultation has performed and she was planned to discharge. She complained about "could not talk". In her neurologic examination, her left arm has lost strength (3/5) and she could hear and understand what was told but couldn't speak. She was transferred to another health center for detection and treatment as pre-diagnose of Transient Ischemic Attack (TIA).

DM never walks alone. At primary health care centers physicians should be aware of chronic conditions as well as the new onset problems to manage.
Relationship between theory of mind and metabolic parameters and functioning in patients with bipolar I disorder
Authors: KULACAOĞLU Filiz , ÜNVER Hasan , YILDIRIM Yusuf Ezel , ERZİN Gamze
Published: January 2023

Purpose: We aimed to investigate the relationship theory of mind abilities with functionality and metabolic alteration in patients with bipolar disorder-1 (BD-1) during the remission period.

Materials and Methods: This cross-sectional study is consisted of 68 patients with bipolar disorder-1 and 45 healthy controls. Sociodemographic form, Reading the Mind in the Eyes Test (RMET), Bipolar Disorder Functioning Questionnaire (BDFQ) were administered to the participants. Body mass index (BMI), waist circumference (WC), fasting plasma glucose (FG), high density lipoprotein cholesterol (HDL), low density lipoprotein cholesterol (LDL), total cholesterol (TC), triglyceride (TG) levels were recorded.

Results: There were significant differences between the patient group and healthy control group in terms of WC, BMI, HDL, LDL, TG. The results of independent samples t-test indicated a statistically significant difference in RMET score between the two groups with control group significantly higher than patient group.

Conclusion: Patients with BD-1 during the remission period have lower performance on theory of mind abilities and more alteration in metabolic parameters than healthy controls. Metabolic alteration and theory of mind impairment should be potential treatment target for BD
Just Singing and Dancing: Official Representations of Ethnic Minority Cultures in China
Authors: Lin Jason Cong , Jackson Liz
Published: January 2023

This paper uses a critical multicultural, constructivist approach to examine how the Chinese government represents minority cultures in its official discourse. Although at an abstract level the government acknowledges the contributions of minority cultures to society, our findings show a mismatched picture in terms of minority representation. Government documents and discourse recorded and obtained on the government website only highlight traditional and stereotypical cultural aspects related to minorities. These representations essentialise minority cultures, obscure their dynamism and their contributions, reinforce power hierarchies, and discourage critical reflexivity. In this context, we recommend addressing fundamental challenges undergirding this pattern in representation to develop more balanced and comprehensive understandings of minority cultures.
Digital Twins for Personalized Healthcare: Application to Radiopharmaceutical Therapies
Authors: Abdollahi Hamid , Rahmim Arman
Published: January 2023

There is significant interest and value in utilizing Digital Twins (DTs) to extend healthcare from ‘one-size-fits-all’ to personalized therapies. Radiopharmaceutical Therapies (RPTs), which represent very powerful developments in the battle against cancer, are no exceptions to this. In fact, Theranostic Digital Twins (TDTs), which we elaborate in this work, present viable and feasible approaches to personalize RPTs. TDTs are computational representations of the human body that, unlike images, are operable; i.e. virtual trials can be conducted on them to propose optimal therapies for individual patients. TDTs can be built using Physiologically Based Pharmacokinetic (PBPK) models. This work elaborates that TDTs can be developed in static, dynamic and interactive modes towards routine use in future clinical settings. TDTs will open a new area of theranostics research and development in terms of new radiopharmaceutical designs, synthesis and enabling of more optimal therapies.
Quantitative Elemental Analysis Using Whole Spectral Information (with GA and MLR Methods) of Proton Induced Prompt Gamma-Rays Simulated Using Geant4 Toolkit
Authors: Saheli Fereshte , Vosoughi Naser , Riazi Zafar , Rasouli Fatemeh S. , Jowkar Alireza
Published: January 2023

Purpose: Online determination of the elemental composition of tissues near the Bragg peak is a challenge in proton therapy related studies. In the present work, an analysis method based on the whole spectral information is presented for the quantitative determination of the elemental composition (weight %) of an irradiated target from its emitted Prompt Gamma (PG) spectrum.
Materials and Methods: To address this issue, four test phantoms with different weights (%) of 12C, 16O, 20Ca, and 14N elements were considered. The simulated PG spectra were recorded using 3 × 3 inch NaI detectors. A library consisting of the spectra of single-element phantoms as well as the spectra of test-irradiated phantoms was produced for 30, 70, and 150 MeV incident protons using the Geant4 Monte Carlo toolkit. The elemental analysis was performed using the information of the whole spectrum by applying two methods, including the well-known Genetic Algorithm (GA) and Multiple Linear Regression (MLR).
Results: The results show that the proposed method estimates the oxygen concentration accurately. Furthermore, the estimated weights of other elements, with both methods, agree well with nominal values in each test phantom, for the considered energies.
Conclusion: The proposed quantitative elemental analysis of proton-bombarded phantoms using their induced PG spectrum is expected to be beneficial in treatment planning and treatment verification studies.
Comment on “Effect of Loaded Glycyrrhizic Acid on PLGA Nano-particle on Treatment of Allergic Asthma”
Authors: Asadi Zahra , Vaisi-Raygani Asad , Aghaz Faranak
Published: January 2023

The Article Abstract is not available.