bluuebunny/crossref_metadata_2025 huggingface dataset:
Local Control Model of a Human Ventricular Myocyte: An Exploration of Frequency-Dependent Changes and Calcium Sparks
Authors: Alvarez Jerome Anthony E. , Jafri M. Saleet , Ullah Aman
Published: August 2023

Calcium (Ca2+) sparks are the elementary events of excitation–contraction coupling, yet they are not explicitly represented in human ventricular myocyte models. A stochastic ventricular cardiomyocyte human model that adapts to intracellular Ca2+ ([Ca2+]i) dynamics, spark regulation, and frequency-dependent changes in the form of locally controlled Ca2+ release was developed. The 20,000 CRUs in this model are composed of 9 individual LCCs and 49 RyRs that function as couplons. The simulated action potential duration at 1 Hz steady-state pacing is ~0.280 s similar to human ventricular cell recordings. Rate-dependence experiments reveal that APD shortening mechanisms are largely contributed by the L-type calcium channel inactivation, RyR open fraction, and [Ca2+]myo concentrations. The dynamic slow-rapid-slow pacing protocol shows that RyR open probability during high pacing frequency (2.5 Hz) switches to an adapted “nonconducting” form of Ca2+-dependent transition state. The predicted force was also observed to be increased in high pacing, but the SR Ca2+ fractional release was lower due to the smaller difference between diastolic and systolic [Ca2+]SR. Restitution analysis through the S1S2 protocol and increased LCC Ca2+-dependent activation rate show that the duration of LCC opening helps modulate its effects on the APD restitution at different diastolic intervals. Ultimately, a longer duration of calcium sparks was observed in relation to the SR Ca2+ loading at high pacing rates. Overall, this study demonstrates the spontaneous Ca2+ release events and ion channel responses throughout various stimuli.
Association of CYP2C9*2 Allele with Sulphonylurea-Induced Hypoglycaemia in Type 2 Diabetes Mellitus Patients: A Pharmacogenetic Study in Pakistani Pashtun Population
Authors: Jan Asif , Saeed Muhammad , Mothana Ramzi A. , Muhammad Tahir , Rahman Naveed , Alanzi Abdullah R. , Akbar Rani
Published: August 2023

Polymorphism in cytochrome P450 (CYP) 2C9 enzyme is known to cause significant inter-individual differences in drug response and occurrence of adverse drug reactions. Different alleles of the CYP2C9 gene have been identified, but the notable alleles responsible for reduced enzyme activity are CYP2C9*2 and CYP2C9*3. No pharmacogenetic data are available on CYP2C9*2 and CYP2C9*3 alleles in the Pakistani population. In Pakistan, pharmacogenetics, which examines the relationship between genetic factors and drug response, are in the early stages of development. We, for the first time, investigated the association between the CYP2C9 variant alleles CYP2C9*2 and CYP2C9*3 and the incidence of hypoglycaemia in patients with Type 2 diabetes mellitus (T2DM) receiving sulphonylurea medications. A total of n = 400 individuals of Pashtun ethnicity were recruited from 10 different districts of Khyber Pakhtunkhwa, Pakistan to participate in the study. The study participants were divided into two distinct groups: the case group (n = 200) and the control group (n = 200). The case group consisted of individuals with T2DM who were receiving sulphonylurea medications and experienced hypoglycaemia with it, whereas the control group included individuals with T2DM who were receiving sulphonylurea medication but did not experience sulphonylurea-induced hypoglycaemia (SIH). Blood samples were obtained from study participants following informed consent. DNA was isolated from whole blood samples using a Wiz-Prep DNA extraction kit. Following DNA isolation, CYP2C9 alleles were genotyped using MassARRAY sequencing platform at the Centre of Genomics at the Rehman Medical Institute (RMI). The frequency of CYP2C9*2 (low-activity allele) was more frequent in the diabetic patients with SIH compared to the control group (17.5% vs. 6.0%, p = 0.021). The frequency of its corresponding genotype CYP2C9*1/*2 was higher in cases compared to the control group (10% vs. 6% with p = 0.036); the same was true for genotype CYP2C9*2/*2 (7% vs. 3.5% with p = 0.028). Logistic regression analysis evidenced potential association of CYP2C9*2 allele and its genotypes with SIH. When adjusted for confounding factors such as age, weight, sex, mean daily dose of sulphonylurea, and triglyceride level, the association between the CYP2C9*2 allele and hypoglycaemia remained consistent. Confounding factors played no role in SIH (insignificant p-value) because both groups (cases and controls) were closely matched in term of age, weight, sex, mean daily dose of sulphonylurea, and triglyceride levels. Our study suggests that genetic information about a patient’s CYP2C9 gene/enzyme can potentially assist physicians in prescribing the most suitable and safest drug, based on their genetic make-up.
Unveiling the Genetic Footprint: Exploring Somatic Mutations in Peripheral Arterial Disease Progression
Authors: Salybekov Amankeldi A. , Hassanpour Mehdi
Published: August 2023

Peripheral arterial diseases (PADs) are complex cardiovascular conditions influenced by environmental factors and somatic mutations in multiple genes involved in hematopoiesis and inflammation. While traditional risk factors, such as smoking, hypercholesterolemia, and hypertension, have been extensively studied, the role of somatic mutations in PAD progression remains underexplored. The present article intends to provide a comprehensive commentary of the molecular mechanisms, genetic landscape, prognostic significance, and clinical implications of somatic mutations in PADs. The expansion of clonal hematopoiesis of indeterminate potential (CHIP) clones in the circulating blood, named clonal hematopoiesis (CH), leads to the infiltration of these clones into atherosclerotic plaques and the production of inflammatory cytokines, increasing the risk of cardiovascular diseases, including PADs. Furthermore, recent experimental evidence has demonstrated the involvement of somatically mutated TP53 genes with a high variant allele frequency (VAF) in PAD development and prognosis. This review delves into the relationship between CH and PADs, elucidating the prevalence, impact, and underlying mechanisms of this association. This understanding paves the way for novel therapeutic approaches targeting CHIP to promote tissue regeneration and improve outcomes in PAD patients. It emphasizes the need for further research to fully unravel the genetic footprint of the disease and highlights potential clinical implications. The findings presented in this article lay the foundation for personalized medicine approaches and open avenues for the development of targeted therapies based on somatic mutation profiling.
Development and Evaluation of a Low-Cost Triglyceride Quantification Enzymatic Biosensor Using an Arduino-Based Microfluidic System
Authors: Pliego-Sandoval Jorge E. , Díaz-Barbosa Arturo , Reyes-Nava Luis A. , Angeles Camacho-Ruiz María , Iñiguez-Muñoz Laura Elena , Pinto-Pérez Osmar
Published: August 2023

Overweight and obesity promote diabetes and heart disease onset. Triglycerides are key biomarkers for cardiovascular disease, strokes, and other health issues. Scientists have devised methods and instruments for the detection of these molecules in liquid samples. In this study, an enzymatic biosensor was developed using an Arduino-based microfluidic platform, wherein a lipolytic enzyme was immobilized on an ethylene-vinyl acetate polymer through physical adsorption. This low-cost optical biosensor employed a spectrophotometric transducer and was assessed in liquid samples to indirectly detect triglycerides and fatty acids using p-nitrophenol as an indicator. The average triglyceride level detected in the conducted experiments was 47.727 mg/dL. The biosensor exhibited a percentage of recovery of 81.12% and a variation coefficient of 0.791%. Furthermore, the biosensor demonstrated the ability to detect triglyceride levels without the need for sample dilution, ranging from 7.6741 mg/dL to 58.835 mg/dL. This study successfully developed an efficient and affordable enzymatic biosensor prototype for triglyceride and fatty acid detection. The lipolytic enzyme immobilization on the polymer substrate provided a stable and reproducible detection system, rendering this biosensor an exciting option for the detection of these molecules.
Explanatory Capacity of Postural Control and Physical Fitness in Cognitive Impairment and Support Needs among Individuals with Intellectual Disabilities—A Cross-Sectional Pilot Study
Authors: Reguera-García María Mercedes , Fernández-Baró Eva , Diez-Vega Ignacio , Varona-Echave Irene , Seco-Calvo Jesús
Published: August 2023

Postural control is a skill associated with most motor activities and is essential for the performance of activities of daily living. People with intellectual disabilities (ID) present postural control deficits that can be attributed to several causes. The aim of this study was to determine whether postural control and physical fitness could explain the cognitive impairment and support needs in this population. A cross-sectional pilot study was conducted with 18 people with ID. Data collection was based on assessments for postural control (Mini BESTest and Berg Balance Scale) and physical fitness (Senior Fitness Test). The data were analyzed using linear regression models. Anticipatory postural adjustments were associated with support needs, explaining up to 45% of these. Consecutive postural adjustments and upper limb strength were less significantly associated with support needs. However, none of the variables used explained cognitive impairment in ID. Knowledge of the relationships and behavior of the different measurement tools is essential for the development of appropriate interventions in this population.
Validation of an Abbreviated Scale of the CENVI Questionnaire to Evaluate the Perception of School Violence and Coexistence Management of Chilean Students: Differences between Pandemic and Post-Pandemic
Authors: Muñoz-Troncoso Flavio , Cuadrado-Gordillo Isabel , Riquelme-Mella Enrique , Muñoz-Troncoso Gerardo , Miranda-Zapata Edgardo , Bizama-Colihuinca Karina , Legaz-Vladímirskaya Ekaterina
Published: August 2023

The objective of the study was to specify an abbreviated model of the school coexistence questionnaire for non-violence (CENVI) for students from 5th to 8th grade (9 to 14 years old), in order to determine the perception of violence and management of school coexistence, and the differences between Mapuche and non-Mapuche students. A total of 1870 students from schools in the city of Temuco (Chile) responded to the CENVI questionnaire. There were two samples: (1) Pandemic, with online, face-to-face and hybrid classes; and (2) Post-pandemic, with face-to-face classes. Sample 1 consisted of 848 students aged 9 to 15 years (M = 11.90; SD = 1.27). Sample 2 consisted of 1022 students aged 9 to 14 years (M = 11.46; SD = 1.14). The questionnaire was validated using expert inter-judgment and Confirmatory Factor Analysis. A good fit of the proposed model to the data and good internal consistency measured according to the composite reliability were found, and convergent validity was demonstrated. Mapuche students perceived more physical violence and social exclusion. Cut-off points were proposed for the interpretation of the results. In the data, the effect of Coexistence Management on School Violence was null. The discussion approaches the findings from the literature on education in spaces of socio-cultural diversity in a Mapuche context.
The Secondary Development and Application of the Improved Nishihara Creep Model in Soft Rock Tunnels
Authors: Deng Xianghui , Shi Junxin , Li Xiaolin , Wang Rui , Zhang Jinzeng , Yang Xin
Published: August 2023

Given the complexity and diversity of rock formations, existing constitutive models struggle to accurately portray their mechanical properties, leading to substantial discrepancies between numerical simulation outcomes and reality. This inadequacy fails to meet the demands of numerical analysis in practical engineering. This study first analyzes the physical and mechanical properties of thin-layered carbonaceous phyllite. Subsequently, an improved Nishihara rheological constitutive model is established based on these analyses. Utilizing the secondary development function offered by FLAC3D, the proposed model is further developed. The program’s correctness and reliability are confirmed through a numerical simulation using the triaxial creep test from existing research. Finally, the established constitutive model is applied in the numerical simulation of an actual soft rock tunnel engineering, obtaining results compared to real monitoring data. The results demonstrate that the improved Nishihara model is more effective at describing the creep deformation characteristics of soft rock. Moreover, the findings from this study can serve as a theoretical reference for predicting deformation in soft rock tunnel engineering.
Assessment of Barriers to the Implementation of Smart Contracts in Construction Projects—Evidence from Turkey
Authors: Budayan Cenk , Okudan Ozan
Published: August 2023

Despite their promising potential, the level of implementation of smart contracts is not at the desired level. To expedite the acceptance and deployment of smart contracts, the barriers to the implementation of smart contracts should be revealed. Past studies, however, do not provide a comprehensive theoretical basis due to several methodological drawbacks. Thus, this study aims to identify and assess the barriers to the implementation of smart contracts by considering the inherent characteristics of the construction industry. An in-depth literature review was initially conducted to extract all barriers proposed in the literature. Then, focus group discussion (FGD) sessions were conducted with the participation of the construction practitioners. In the FGD session, the results of the literature review were validated, and nine additional barriers were proposed. Finally, a total of 20 barriers under five categories was proposed for the smart contract adoption in the construction industry. Then, a questionnaire survey was conducted with the participation of 15 construction practitioners. Lastly, fuzzy VIKOR analysis was performed to assess the criticality of the implementation barriers. This study indicates that the construction companies should overcome not only technical barriers but also managerial barriers. Changes in the processes arisen due to smart contract implementation prevent the construction from implementing a smart contract, since the employees show resistance to these changes. Furthermore, the companies believe that they can lose their bargaining power with smart contracts, and they do not want to lose their power. Bottlenecks are considered the most critical barrier from a technological perspective, and companies are concerned about the problems resulting from them. Although this study provides insights into the barriers to smart contracts in the construction industry, all the respondents are from Turkey. Therefore, some of the findings of this study can be specific to the Turkish construction industry.
Effect of Indoor Wall Wood Coverage on the Elderly Group—A Case Study of Activity Rooms in Old-Age Buildings
Authors: Yan Di , Guo Qishen
Published: August 2023

Wood finds extensive utilization in the design of indoor environments due to its natural and visual weighty characteristics. However, the visual perception of the elderly group towards their surroundings differs from that of other age groups, resulting in distinct requirements for the visual environment. Taking the activity room of an old-age building as a case study, this research employs a focus group to identify the factors and levels that influence the acceptance of wood among older individuals, subsequently designing various simulation scenarios. The semantic differential method and physiological monitoring enable the collection of psychological and physiological evaluations. The findings reveal that the increases in wood coverage significantly impact the psychological and physiological perceptions of older individuals, with acceptance of the environment increasing initially and then decreasing. In terms of physiology, the incorporation of wooden wall designs in indoor spaces assists in regulating essential physiological indicators such as heart rate and blood pressure. In conclusion, the implementation of indoor wood design positively influences the psychological and physiological perceptions of older individuals, thereby providing valuable guidance for the design of healthy indoor environments.
Supply–Demand Matching of Smart Parcel Lockers in a Residential Area: Insights from Tianjin
Authors: Ding Mengyue , Song Yan , Hu Yike
Published: August 2023

The COVID-19 pandemic has led to a surge in the use of self-service facilities (SSFs) in residential areas worldwide. Previous studies on SSFs mainly focused on their application in commercial or other scenarios. However, SSFs in residential areas have not been thoroughly studied. This study develops an analytical framework for assessing both the supply and demand for SSFs in residential areas. The study evaluates 2693 residential communities and 479 smart parcel lockers (SPLs) in Tianjin, China. The results show that the high-demand area for SPLs is within 300 m of home, while the high-supply area is 300–600 m from home. Further analysis using the Gini coefficient and location quotient shows that the top 20% of the population have access to 80% of SPLs, and most residential communities experience an oversupply. Our study suggests that a mismatch between the supply and demand of SPLs may result in massive public space waste, resource waste, and inequity. Given the many uncertainties of the future, this study highlights the need to consider the dynamic supply–demand relationship of SSFs. This may encourage urban planners, policymakers, and experts in other related disciplines to work towards a more service-efficient and equitable utilization of SSFs in residential areas.
Construction Work-Stage-Based Rule Compliance Monitoring Framework Using Computer Vision (CV) Technology
Authors: Khan Numan , Zaidi Syed Farhan Alam , Yang Jaehun , Park Chansik , Lee Doyeop
Published: August 2023

Noncompliance with safety rules is a major cause of unsatisfactory performance in construction safety worldwide. Although some research efforts have focused on using computer vision (CV) methods for safety rule inspection, these methods are still in their early stages and cannot be effectively applied on construction job sites. Therefore, it is necessary to present a feasible prototype and conduct a detailed analysis of safety rules to ensure compliance at the job site. This study aims to extend the validation of safety rule analysis through four case scenarios. The proposed structured classification of safety rules includes categorizing them based on project phases and work stages. The construction phase-related rules are divided into four groups: (1) before work, (2) with intervals, (3) during work, and (4) after work. To validate the proposed framework, this research developed prototypes for each group’s scenarios using deep learning algorithms, a storage database to record compliance with safety rules, and an Android application for edge computing, which is required in the “before work” and “after work” groups. The findings of this study could contribute to the development of a compact CV-based safety monitoring system to enhance the current safety management process in the construction industry.
Excellent Performance and Feasible Mechanism of ErOx-Boosted MnOx-Modified Biochars Derived from Sewage Sludge and Rice Straw for Formaldehyde Elimination: In Situ DRIFTS and DFT
Authors: Wang Jiajie , Gao Lei , Xie Dong , Li Caiting , Xiang Liping , Jiang Yun , Xu Qing , Xiong Huiyu , Yi Lei , Liu Jie , Wu Jiajun
Published: August 2023

To avoid resource waste and environmental pollution, a chain of ErOx-boosted MnOx-modified biochars derived from rice straw and sewage sludge (EryMn1-y/BACs, where biochars derived from rice straw and sewage sludge were defined as BACs) were manufactured for formaldehyde (HCHO) elimination. The optimal 15%Er0.5Mn0.5/BAC achieved a 97.2% HCHO removal efficiency at 220 °C and exhibited favorable EHCHO and thermal stability in a wide temperature window between 180 and 380 °C. The curbed influences of H2O and SO2 offset the boosting effect of O2 in a certain range. Er–Mn bimetallic-modified BACs offered a superior HCHO removal performance compared with that of BACs boosted using Er or Mn separately, owing to the synergistic effect of ErOx and MnOx conducive to improving the samples’ total pore volume and surface area, surface active oxygen species, promoting redox ability, and inhibiting the crystallization of MnOx. Moreover, the support’s hierarchical porous structure not only expedited the diffusion and mass transfer of reactants and their products but also elevated the approachability of adsorption and catalytic sites. Notably, these prominent features were partly responsible for the outstanding performance and excellent tolerance to H2O and SO2. Using in situ DRIFTS characterization analysis, it could be inferred that the removal process of HCHO was HCHOad → dioxymethylene (DOM) → formate species → CO2 + H2O, further enhanced with reactive oxygen species. The DFT calculation once again proved the removal process of HCHO and the strengthening effect of Er doping. Furthermore, the optimal catalytic performance of 15%Er0.5Mn0.5/BAC demonstrated its vast potential for practical applications.
Closed-Loop Stability of a Non-Minimum Phase Quadruple Tank System Using a Nonlinear Model Predictive Controller with EKF
Authors: Oyehan Ismaila A. , Osunleke Ajiboye S. , Ajani Olanrewaju O.
Published: August 2023

The dynamics of a quadruple tank system (QTS) represent an extensive class of multivariate nonlinear uncertain systems found in the industry. It has been established that changes in split fractions affect the transmission zero location, thereby altering the operating conditions between the minimum and non-minimum phase regions. The latter is difficult to control as more fluid flows into the two upper tanks than into the two bottom tanks, resulting in competing effects between the initial and final system responses. This attribute, alongside nonlinearity, uncertainties, constraints, and a multivariate nature, can degrade closed-loop system performance, leading to instability. In this study, we addressed the aforementioned challenges by designing controllers for the regulation of the water flow in the two bottom tanks of the QTS. For comparative analysis, three controller algorithms—a nonlinear model predictive controller (NMPC), NMPC augmented with an extended Kalman filter (i.e., NMPC-EKF) and linear model predictive controller (LMPC)—were considered in the analysis and design of the control mechanism for the quadruple water level system in a non-minimum phase condition via the Matrix Laboratory (MATLAB) simulation package environment. The simulated and real-time results in the closed loop were analyzed, and the controller performances were considered based on faster setpoint responses, less oscillation, settling time, overshoot, and smaller integral absolute error (IAE) and integral square error (ISE) under various operational conditions. The study showed that the NMPC, when augmented with an EKF, is effective for the control of a QTS in the non-minimum phase and could be designed for more complex, nonlinear, and multivariable dynamics systems, even in the presence of constraints.
Quantitative Detection of the Influenza a Virus by an EGOFET-Based Portable Device
Authors: Poimanova Elena Y. , Zavyalova Elena G. , Kretova Elena A. , Abramov Anton A. , Trul Askold A. , Borshchev Oleg V. , Keshek Anna K. , Ponomarenko Sergey A. , Agina Elena V.
Published: August 2023

Elaboration of biosensors on the base of organic transistors with embedded biomolecules which can operate in an aqueous environment is of paramount importance. Electrolyte-gated organic field-effect transistors demonstrate high sensitivity in detection of various analytes. In this paper, we demonstrated the possibility of quantitative fast specific determination of virus particles by an aptasensor based on EGOFET. The sensitivity and selectivity of the devices were examined with the influenza A virus as well as with control bioliquids like influenza B, Newcastle disease viruses or allantoic fluid with different dilutions. The influence of the semiconducting layer thickness on EGOFETs sensory properties is discussed. The fabrication of a multi-flow cell that simultaneously registers the responses from several devices on the same substrate and the creation of a multi-sensor flow device are reported. The responses of the elaborated bioelectronic platform to the influenza A virus obtained with application of the portable multi-flow mode are well correlated with the responses obtained in the laboratory stationary mode.
The Effect of a Short-Term Occupational Therapy Intervention on the Participation and Personal Factors of Preschoolers with Developmental Disabilities
Authors: Soref Bosmat , Robinson Gary L. , Bart Orit
Published: August 2023

Background: Preschoolers with developmental disabilities are referred to occupational therapy due to their decreased participation in daily life occupations. The purpose of this study was to evaluate the improvement in preschoolers’ participation and sensory-motor abilities following an occupational therapy intervention. Materials and Methods: A prospective cohort study of 38 preschoolers and their parents was conducted using an interrupted time-series design, including assessments at three time points: base line (upon referral to an occupational therapy assessment), pre-intervention, and post-intervention after 9–12 sessions of occupational therapy interventions. Children were evaluated with the Developmental Test of Visual–Motor Integration, as well as the balance and fine motor precision sub tests of the Bruininks–Oseretsky Test of Motor Proficiency. Parents completed the Children’s Participation Questionnaire and the Child Performance Skills Questionnaire. Each intervention session was documented by the therapists using the Documentation of Occupational Therapy Session Intervention form. Results: Significant improvement in children’s sensory–motor abilities were found in balance, visual integration, and fine motor precision post-intervention. There were also improvements in the measures of diversity, children’s independence, and parental satisfaction. Conclusions: A short-term occupational therapy intervention applied to preschoolers with developmental disabilities is effective in improving their sensory–motor abilities, as well as in promoting their participation in daily activities.
Under the Surface: Climatic and Societal Challenges in Marine Spatial Planning in the Westfjords of Iceland
Authors: Wilke Maria , Kristjánsdóttir Sigríður
Published: August 2023

As the global climate is changing dramatically, the Westfjords of Iceland are facing a multitude of challenges, including changing weather patterns, sea level rise, and invasive species. In order to cope with the recent climatic changes—many of which present great uncertainties to livelihoods—strategies must be developed to plan and adapt for the future. Iceland has recently launched marine spatial planning (MSP) endeavours, and one of the first planning processes has been conducted in the Westfjords. MSP presents opportunities for authorities, stakeholders, and the public to come together to forge a sustainable path ahead for marine areas that are under increasing pressure from human activities. However, MSP comes with its own considerable challenges as it attempts to engage stakeholders and the general public in decisions about an ‘invisible’ space largely beneath the surface of the sea. In this paper, the uncertainties of the environmental changes will be explored in conjunction with the multitude of societal challenges to coastal and marine planning in the Westfjords to establish Iceland’s unique context for MSP and to make recommendations for its development. Data from the planning documents as well as from semi-structured interviews and a workshop conducted in the Westfjords will be analysed and discussed. The results show both an urgent environmental need to take action to adapt to ongoing climate change effects and a complex societal structure that favours those who already have power and influence over others. Our recommendations include reforming the Icelandic MSP process with a view to strengthening the public participatory channels as well as the transparency, trust, and accessibility of the process.
Determination of Thermal Damage Threshold in THz Photomixers Using Raman Spectroscopy
Authors: Mikulics Martin , Adam Roman , Chen Genyu , Chakraborty Debamitra , Cheng Jing , Pericolo Anthony , Komissarov Ivan , Bürgler Daniel E. , Heidtfeld Sarah F. , Serafini John , Preble Stefan , Sobolewski Roman , Schneider Claus M. , Mayer Joachim , Hardtdegen Hilde H.
Published: August 2023

The increase of device lifetime and reliability of THz photomixers will play an essential role in their possible future application. Therefore, their optimal work conditions/operation range, i.e., the maximal incident optical power should be experimentally estimated. We fabricated and tested THz photomixer devices based on nitrogen-implanted GaAs integrated with a Bragg reflector. Raman spectroscopy was applied to investigate the material properties and to disclose any reversible or irreversible material changes. The results indicate that degradation effects in the photomixer structures/material could be avoided if the total optical power density does not exceed levels of about 0.7 mW/µm2 for 100 min of operation. Furthermore, the investigations performed during 1000 min of optical exposure on the photomixer devices’ central region comprising interdigitated metal-semiconductor-metal (MSM) structures suggest a reversible “curing” mechanism if the power density level of ~0.58 mW/µm2 is not exceeded. Long-term operation (up to 1000 h) reveals that the photomixer structures can withstand an average optical power density of up to ~0.4 mW/µm2 without degradation when biased at 10 V. Besides the decrease of the position of the A1g (LO) Raman mode from ~291 cm−1 down to ~288 cm−1 with increasing optical power density and operation time, broad Raman modes evolve at about 210 cm−1, which can be attributed to degradation effects in the active photomixer/MSM area. In addition, the performed carrier lifetime and photomixer experiments demonstrated that these structures generated continuous wave sub-THz radiation efficiently as long as their optimal work conditions/operation range were within the limits established by our Raman studies.
Clinical Considerations for the Integration of Adjuvant Olaparib into Practice for Early Breast Cancer: A Canadian Perspective
Authors: Henning Jan-Willem , Boileau Jean-François , Peck Larissa , McFarlane Tom
Published: August 2023

With the recent Health Canada approval of olaparib for high-risk, HER2-negative early breast cancer, physicians are now facing the practical challenges of integrating olaparib into current management of triple-negative breast cancer (TNBC) and HR-positive, HER2-negative (HR+/HER2−) early breast cancer. This review provides perspectives on some of the challenges related to identification of olaparib candidates, with a focus on the latest guidance for germline BRCA testing and considerations regarding high-risk disease definitions. Updated treatment pathways are explored for both disease states, including other adjuvant treatment options such as pembrolizumab, capecitabine, and abemaciclib. Gaps in the current literature regarding the sequential or combined use of these adjuvant therapies are noted and future, potentially informative, studies are briefly examined.
Spatiotemporal Variability in Fish Assemblages in a Coastal and Estuarine System in the Tropical Eastern Pacific during the Anthropause
Authors: Hernández-Álvarez Yareli , Ramírez-Ortiz Georgina , Flores-de-Santiago Francisco , Amezcua-Linares Felipe , Muro-Torres Victor , Arceo-Carranza Daniel , Amezcua Felipe
Published: August 2023

Differences in fish assemblages’ composition and their relationship with the environmental variables were analyzed in the Urías estuarine system, Mexican North Pacific. Environmental variables and fish catches were recorded bimonthly between June 2018 and November 2021, including a period before and during the COVID-19 pandemic. Multivariate analyses were performed in the studied area to define zones based on their environmental, biotic, and abiotic characteristics and the effect of these on the fish assemblages. Two zones were identified, an estuarine with mangrove forest and a surf zone in the coastal area outside the estuarine system. Fish composition, biomass, and diversity (α and β) were evaluated among the factors of the period (before–during COVID-19), climatic seasons, and zones. A total of 5947 fish individuals of 41 species were collected using beach seines as fishing gear. The structure of the fish assemblages was different between zones and periods. Abiotic (temperature, salinity, and total matter suspended), biotic (mangrove area), and temporal (season and period before–during COVID-19) variables had an effect on fish biomass and α diversity, while the results of the β diversity only indicate changes in the nestedness component before–during the lockdown. These results indicate a change in fish assemblages’ structure and composition between periods, which might be a consequence of the limitation of human activities derived from the pandemic, climatic changes, or a combination of both effects. Our results show that fish assemblages in the estuarine systems of the Tropical Eastern Pacific are unique, and there is a need to establish local management strategies for these ecosystems.
Ant Species Diversity in the Central and Northern Parts of the Western Sichuan Plateau in China
Authors: Li Zhao-Yi , Xu Zheng-Hui , Zhang Xin-Min , Li Ting , Yin Xiao-Dan , Duan Jia-Huan
Published: August 2023

Understanding how species richness changes along elevational gradients has attracted increasing attention from many researchers. The relationships between species richness and elevations were characterized by monotonic decreases or mid-elevational peaks. The western Sichuan Plateau is an important species diversity hotspot. However, there is little information available about the ant species diversity and distribution patterns of this region. In this study, we hypothesize that ant diversity will show a monotonic decrease from mid-elevation with increasing elevation. Here, the ant species diversity and distribution patterns of this region were investigated by plot surveys. A total of 22,645 ants were collected from eight elevational transects in the central and northern parts of the western Sichuan Plateau, which were identified as belonging to 40 species, 18 genera, and 4 subfamilies. We found a unimodal relationship between elevation and ant species richness, with the highest ant species richness occurring at mid-elevations. The similarity coefficient of ant communities in each elevational transect was at a moderate level of dissimilarity, indicating that the elevation difference and habitat heterogeneity had a great impact on ant communities in the central and northern areas of the western Sichuan Plateau.
Efficient Numerical Simulation of Biochemotaxis Phenomena in Fluid Environments
Authors: Zhou Xingying , Bian Guoqing , Wang Yan , Xiao Xufeng
Published: August 2023

A novel dimension splitting method is proposed for the efficient numerical simulation of a biochemotaxis model, which is a coupled system of chemotaxis–fluid equations and incompressible Navier–Stokes equations. A second-order pressure correction method is employed to decouple the velocity and pressure for the Navier–Stokes equations. Then, the alternating direction implicit scheme is used to solve the velocity equation, and the operator with dimension splitting effect is used instead of the traditional elliptic operator to solve the pressure equation. For the chemotactic equation, the operator splitting method and extrapolation technique are used to solve oxygen and cell density to achieve second-order time accuracy. The proposed dimension splitting method splits the two-dimensional problem into a one-dimensional problem by splitting the spatial derivative, which reduces the computation and storage costs. Finally, through interesting experiments, we show the evolution of the cell plume shape during the descent process. The effect of changing specific parameters on the velocity and plume shape during the descent process is also studied.
Quantum Knowledge in Phase Space
Authors: Geiger Davi
Published: August 2023

Quantum physics through the lens of Bayesian statistics considers probability to be a degree of belief and subjective. A Bayesian derivation of the probability density function in phase space is presented. Then, a Kullback–Liebler divergence in phase space is introduced to define interference and entanglement. Comparisons between each of these two quantities and the entropy are made. A brief presentation of entanglement in phase space to the spin degree of freedom and an extension to mixed states completes the work.
First Year Engineering Students’ Difficulties with Math Courses- What Is the Starting Point for Academic Teachers?
Authors: Charalambides Marios , Panaoura Rita , Tsolaki Eleni , Pericleous Savvas
Published: August 2023

The discussion about first-year engineering students’ difficulties in mathematics is continuous in the fields of engineering, mathematics and higher education. The present study aimed to examine the initial barriers academic math teachers need to have in mind if they want to improve students’ performance in engineering math courses through appropriate teaching practices in order to face their initial interindividual differences. During the first phase of the study, we examined first year engineering students’ initial beliefs about the nature of mathematics, their self-efficacy beliefs about mathematics and their basic mathematical knowledge. The math school grade was used for their previous mathematical performance. Results indicated the predominant role of the previous mathematical knowledge and the important role of the formalistic disposition toward mathematics. The lack of experience of using mathematics for problem-solving situations within an engineering framework prevented students from recognizing and appreciating the value of mathematical courses during the engineering studies. The second phase of the study examined, through an interview with a group of students, their perceptions of the teaching practices which were introduced after their teacher attended a training program. The discussion concentrates on how academics can use teaching processes for equity and not equality in order to motivate their students.
Leveraging IoT to Address Separation Anxiety in Preschoolers: A Techno-Psychological Approach
Authors: Alabduljabbar Reham , Alsakran Raseel
Published: August 2023

Separation anxiety disorder (SAD) is a prevalent psychological disorder among preschoolers, characterized by excessive fear or anxiety related to separation from a primary attachment figure. The COVID-19 pandemic likely exacerbated the problem due to the transition to online schooling. While some attention has been given to treating SAD, most current solutions are non-technical and based on behavior analytic research which can be costly and time-consuming. Mediated social touch, which uses technology to simulate physical touch and deliver it remotely, has been extensively studied for its potential to promote wellbeing, enhance social connectedness, and improve affective experiences in various contexts. However, no research has focused on the use of such technology to manage SAD in preschoolers. To address this gap, this work presents the design, development, and evaluation of a novel mediated social touch system aimed at managing separation anxiety in preschoolers. Specifically, the study investigates the effectiveness of using IoT in huggable interfaces and game-based applications in improving children’s emotional state and adaptation to the kindergarten environment. Through experiments conducted on a sample of nearly 30 preschoolers, the results have shown that the system is effective in helping preschoolers adapt to kindergarten, with the best results achieved when using the huggable interface and the developed game together. The implications of this study may be beneficial to parents, educators, and mental health professionals who work with preschoolers who experience SAD.
Simulation-Based Headway Optimization for the Bangkok Airport Railway System under Uncertainty
Authors: Sasithong Pruk , Parnianifard Amir , Sinpan Nitinun , Poomrittigul Suvit , Saadi Muhammad , Wuttisittikulkij Lunchakorn
Published: August 2023

The ever-increasing demand for intercity travel, as well as competition among all modes of transportation, is an unavoidable reality that today’s urban rail transit system must deal with. To meet this problem, urban railway companies must try to make better use of their existing plans and resources. Analytical approaches or simulation modeling can be used to develop or change a rail schedule to reflect the appropriate passenger demand. However, in the case of complex railway networks with several interlocking zones, analytical methods frequently have drawbacks. The goal of this article is to create a new simulation-based optimization model for the Bangkok railway system that takes into account the real assumptions and requirements in the railway system, such as uncertainty. The common particle swarm optimization (PSO) technique is combined with the developed simulation model to optimize the headways for each period in each day. Two different objective functions are incorporated into the models to consider both customer satisfaction by reducing the average waiting time and railway management satisfaction by reducing needed energy usage (e.g., reducing operating trains). The results obtained using a real dataset from the Bangkok railway system demonstrate that the simulation-based optimization approach for robust train service timetable scheduling, which incorporates both passenger waiting times and the number of operating trains as equally important objectives, successfully achieved an average waiting time of 11.02 min (with a standard deviation of 1.65 min) across all time intervals.
Operation of the System of Coupled Low-Voltage Feeders during Short-Circuit Faults
Authors: Shahnia Farhad
Published: August 2023

As a technique to control the voltage drop at network peak periods and voltage rise at middays when a high number of rooftop photovoltaic systems exist in a low-voltage feeder (LVF), two or more neighboring LVFs can be coupled. To add voltage controllability to the coupling point, a distribution static compensator (DSTATCOM) can be installed. An important issue for such a system is its operation under short-circuit conditions in one of the LVFs and relevant protection aspects. This paper investigates the performance of such a system under fault conditions and presents a protection scheme that can achieve the desired operation of the system, under short-circuit faults in either of the LVFs. The performance of the system of coupled LVFs is investigated by numerical analysis in MATLAB while the dynamic feasibility of the proposed technique is validated by simulation studies in PSCAD/EMTDC.
Integrating Advanced Technologies for Sustainable Construction Purposes
Authors: Chong Heap-Yih , Cheng Mengyuan
Published: August 2023

The trend of integrating sustainability into construction activities has sought to meet the growing demands of sustainable development [...]
Power Smoothing Strategy for Wind Generation Based on Fuzzy Control Strategy with Battery Energy Storage System
Authors: Tabosa da Silva Pablo L. , Rosas Pedro A. Carvalho , Castro José F. C. , Marques Davidson da Costa , Aquino Ronaldo R. B. , Rissi Guilherme F. , Neto Rafael C. , Barbosa Douglas C. P.
Published: August 2023

This work discusses the use of a battery energy storage system applied to the smoothing of power generated at the output of wind turbines based on a fuzzy logic power control. The fuzzy control logic proposed can perform the aforementioned activity while the state of charge of the energy storage system is maintained within operational limits. In order to assess the fuzzy logic power control’s effectiveness at maintaining the state of charge levels within the allowed range, two operating situations are explored: one in which the state of charge is above the upper limit allowed, and another in which the state of charge is in the minimum value allowed. The numerical results show that, when using the battery energy storage system in conjunction with the control logic proposed, the active power provided as the point of common coupling by the wind turbines can be smoothed, thus contributing to the Electric Power System reliability and stability. The main results of this paper are based on measurements of wind and active power associated with a wind generation plant installed in the northeast region of Brazil and equipped with 2.1 MW wind turbines.
Acid-Soluble Drilling Fluid in the Northern Carbonate Reservoir of the Yishan Slope in the Ordos Basin
Authors: Zhang Xiaolin , Dang Binhua , Wang Xuecheng , Luo Shun , Chen Bugao , Zheng Lihui
Published: August 2023

The carbonate reservoir in the northern Yishan slope of the Ordos Basin presents significant challenges to gas field exploration and development. With its low pressure, limited porosity, low permeability, and abundance of micro-fractures, the reservoir is resistant to acid dissolution. Once solid particles block these fractures during drilling and completion, serious reservoir damage ensues. To address these obstacles, we engineered an acid-soluble, solid-free drilling fluid system in the lab. This involved incorporating sodium carboxymethyl cellulose, heat-resistant starch, fungicides, and lubricants. Contrasted with the commonly used potassium ammonium based drilling fluid system, our innovative solution showed notable improvements. Specifically, the density decreased by 0.04 to 0.06 g/cm3, and the solid content decreased by 4.0% to 6.50%, while the acid-soluble rate surged from 8.50% to 95.45%. In addition, the reservoir permeability recovery value saw an increase from 51.50% to 95.88%. In practical field application, we employed this novel drilling fluid system in ten horizontal wells. Following acid fracturing and reconstruction, these wells registered a 75.94% increase in gas production compared to nearby wells. Our findings demonstrate that the proposed system effectively mitigates the incursion of solid-phase particles into the reservoir while enhancing acidification during acid fracturing. This results in the swift removal of plugging, restoration of formation permeability, and improved well production. Our research thus introduces a drilling and completion fluid system of high efficiency with superior reservoir protection performance, potentially offering substantial benefits to the development of carbonate rock salt gas reservoirs.