bluuebunny/crossref_metadata_2025 huggingface dataset:
The Use of Botulinum Toxin in Oculoplasty
Authors: Lepska Katarzyna , Różycki Radosław , Różycka Małgorzata
Published: February 2024

Botulinum toxin is one of the strongest functional organic toxins. Throughout history, detailed research has contributed to changing the perception of this substancefrom a toxin to a widely used medication. Botulinum toxin has found therapeutic use in many fields of medicine, and indications for its use are constantly widening in a variety of diseases that all characterize muscular hyperactivity. Intramuscular injection causes a transient paralysis, by acting on the motorend-plate of the neural axon and blocking a release of acetylcholine. In oculoplasty, it is used in treating localized dystonia such as :eyelid droop and facial hemiparesis, lower eyelid curl, eyelid retraction in cases of thyroid ophthalmopathy, treatment of non-healing corneal ulcers such as post-paresis upper eyelid insufficiency and dry-eye syndrome. In the general field of ophthalmology, the use of botulinum toxin successfully treats strabismus as well as otherextraocular muscle disorders that are present in nystagmus as well as Grave’s disease.
The aim of this scientific study is to analyze the possibilities of botulinum toxin injections in various ophthalmic disorders, considering their potential as an alternativeto traditional surgeries, and discussing their benefits and risks. The research methodology relies on a systematic review of literature available in medical databases, analyzing publications and clinical studies related to botulinum toxin injections in ophthalmology.
Since its discovery, botulinum toxin has undergone a remarkable transformation, from a deadly poison to a medicine used in various fields of medicine.
When administered in appropriate doses, at proper intervals, and by qualified personnel, it becomes a safe form of the rapyfor numerous medical conditions characterized by excessive muscle activity.
Ophthalmological Complications following Aesthetic Medicine Procedures
Authors: Korwin Magdalena , Kowalewska Dorota , Dziedziak Jacek , Kamińska Anna , Szaflik Jacek P.
Published: February 2024

Aesthetic medicine is one of the most intensively developing branch of medicine worldwide. Additionally, the reis an increasing number of physician who start to perform the procedures and therefore increasing number of the treatments. As any medical procedure it can be associated with complications. The authors describe possible complications affecting peri ocular area following aesthetic procedures performed on the face.
Vascular Complications Following Aesthetic Procedures with Hyaluronic Acid Fillers Use
Authors: Korwin Magdalena , Kowalewska Dorota , Dziedziak Jacek , Kamińska Anna , Szaflik Jacek P.
Published: February 2024

Aesthetic medicine deals with patients’ quality of life improvement by reducing imperfections in appearance. It focuses on inhibiting and slowing down ageing and wrinkles reduction. One of the most frequently performed procedures is hyaluronic acid fillers injections to fill and improve volume loss, deep folds and wrinkles. Those products have the gel characteristics, therefore their injection into the tissues may be associated with complications development, including vascular occlusion.
The authors describe variety of possible vascular complications following aesthetic procedures with special attention paid to blindness and management algorithms in such cases.
Endophthalmitis Following Cataract Surgery – Is the Problem Still Present?
Authors: Jasielska Monika , Burakowska Aleksandra , Mackiewicz Jerzy
Published: February 2024

Purpose

The aim of this study is to present a group of patients who were diagnosed and treated for postoperative endophtalmitis following cataract surgery.

Material and Methods

The study included four patients two women and two men aged 53 to 89 who underwent cataract surgery two days previous. Acute postoperative endophtalmitis was diagnosed in these patients and vitrectomy was performed immediately upon admission to the clinic.

Results

In the first few days after vitrectomy the patients reported a reduction in eye pain and photophobia. Methicillin-resistant, coagulase-negative Staphylococcus epidermidis was isolated from intraoperatively collected material. Following the treatment five months after the initial surgery the patients showed an improvement in visual acuity from hand movement in front of the eye, finger counting from 0.5 meters to a range of 0.1 to 0.7 on the Snellen scale.

Discussion

In the analyzed group of patients with postoperative endophtalmitis the most common pathogen responsible for the development of this inflammation as described in the literature was isolated. The use of surgical treatment, full and early vitrectomy, yielded positive results that included the remission of subjective symptoms, improvement of the local condition and visual improvement.

Conclusions

Postoperative endophtalmitis is still a significant complication of cataract surgery within our practice. The use of an appropriate therapeutic procedure in our opinion – the vitrectomy can lead to very good postoperative outcomes.
Vitrectomy 23 G with Vascular Endothelial Growth Factor Injection in a Patient with Neovascular Glaucoma with Total Retinal Detachment, Hemorrhage into Anterior Chamber and Vitreous Chamber of the Right Eye – Case Report
Authors: Sirek Sebastian , Woszczek Dawid , Leszczyński Rafał , Mukwa-Kominek Ewa
Published: February 2024

Introduction

Neovascular glaucoma is a serious eye disease characterized by neovascularization of their is and anterior chamber angle. The most important risk factors for the development of neovascular glaucoma include retinal ischemia including that caused by proliferative diabetic retinopathy, central retinal vein occlusion, or retinal detachment.

Material and Methods

A 61-year-old man with anterior chamber and vitreous chamber hemorrhage, recurrent total retinal detachment and advanced neovascular glaucoma in the right eye.

Results

Visual acuity recorded as hand motion, intraocular pressure measured by applanation tonometry 16 mmHg. The anterior segment showed massive anterior chamber hemorrhage and iris neovascularization. Ultrasound examination of the right eyeball in the B projection showed multiple diffuse extra echoes consistent with hemorrhage into the vitreous chamber and flat total retinal detachment. The patient was scheduled for anterior chamber washout, 23 G posterior vitrectomy with retinal endolaser, silicone oil endotamponade and injection of ranibizumab into the vitreous chamber of the right eye. During the first follow-up, an improvement in visual acuity to a level of 1/50 using Snellen arrays, stabilization of intraocular pressure to a level of 11 mmHg, and retinal adhesion was achieved.

Conclusions

Pars plana vitrectomy in patients with anterior chamber and vitreous chamber hemorrhage, retinal detachment and neovascular glaucoma is an effective surgical procedure for restoring useful visual acuity. In addition, ranibizumab injection has a direct effect on reducing the level of intraocular vascular endothelial growth factor and causes regression of neovascularization in the retina, angle and iris.
LuxSmart™ Intraocular Lens – EDOF Tailored To the Needs of a Modern Patient
Authors: Ordon Agata J. , Nowik Katarzyna , Pielak Karolina , Szaflik Jacek P.
Published: February 2024

Enhanced depth of focus intraocular lenses had been successfully introduced few years ago. This heterogenous class of intraocular lenses aims to correct presbyopia and provide a spectacle independence for daily activities over a wider range than classic monofocal intraocular lenses. LuxSmart (Bausch & Lomb) is a high-quality enhanced depth of focus intraocular lens. This single piece, acrylic hydrophobic and aspheric intraocular has a small central zone which combines 4th and 6th orders of spherical aberration of opposite signs to increase the subjective depth of focus and further improve intermediate vision while maintaining good performance at distance. This article presents preliminary clinical outcomes and patient satisfaction of LuxSmart™ intraocular lens.
Oh, It Hurts – Perioperative Pain in Cataract Surgery
Authors: Langwińska Ewa , Pielak Karolina , Ordon Agata J. , Malinowska Katarzyna
Published: February 2024

Pain and anesthesia are important parts of the perioperative management of patients undergoing cataract surgery. They affect the quality of life and the readiness to undergo another procedure.
The level of anxiety, pain, and it’s intensity occur with different frequencies.
The group of patients who underwent uncomplicated phacoemulsification cataract surgery under local anesthesia and intravenous sedation was asked to complete an anonymous questionnaire, taking into account several factors such as age, gender, level of education, level of anxiety before surgery, nature of pain, previous procedures, general diseases and other.
The study aims to compare the frequency and intensity of perioperative pain during first and second eye surgery and to list predisposing factors to pain during cataract surgery.
Allergic Conjunctivitis
Authors: Ciepiaszuk Karolina , Langwińska Ewa , Szaflik Jacek P. , Szaflik Jerzy
Published: February 2024

Allergic conjunctivitis is the most common manifestation of conjunctivitis, affecting up to 40% of the population, mostly children and young adults. Among the risk factors there are air pollution, southern latitude and coexisting allergy. The disease develops when IgE-class antibodies are activated by an allergen and later Th2-dependent humoral response is activated. In seasonal and perennial allergic conjunctivitis the symptoms are limited to conjunctiva, however in vernal keratoconjunctivitis and atopic keratoconjunctivitis also the cornea can be affected. Giant papillary conjunctivitis is not an allergy but a response to irritating surface agents, most frequently a contact lens. In treatment there are three groups of medications used: antihistaminic, non-steroid anti inflammatory and steroids. Due to rise of allergic conjunctivitis, it is crucial to accurately diagnose and treat those conditions.
Fungal Keratitis
Authors: Trojacka Ewelina , Izdebska Justyna , Szaflik Jacek P.
Published: February 2024

Fungal keratitis are important problem in ophthalmology. The most often isolated ethiologic factors are Candida species, Fusarium species and Aspergillus species. Microbiological diagnostics of mycotic infections is long-lasting and has low susceptibility. Effectiveness of antifungal therapy is limited by pathogenes resistance and specific pharmacokinetics of medications used in therapy of eye ball infections.
Meibomian Gland Dysfunction as a Cause of Eye Surface Inflammation
Authors: Kiziak Marta , Langwińska Ewa , Szaflik Jacek P.
Published: February 2024

Meibomian glands dysfunction is described as one of the most common ophthalmic diseases in the world. Meibomian glands dysfunction is the most common cause of posterior blepharitis. Meibomian glands are the only ones responsible for the production of the tear film lipid layer. There are many diseases which induce Meibomian glands dysfunction, even leading to their disappearance. It is concluded that Meibomian glands dysfunction can both cause and result from dry eye syndrome through a process of events involving inflammation of the ocular surface. Accurate diagnosis becomes a great challenge, and it is of key importance in selecting the optimal form of treatment. This article provides an overview of the current understanding of Meibomian gland dysfunction and its therapeutic outlook.
Inflammation in Dry Eye Disease
Authors: Przybek-Skrzypecka Joanna , Szaflik Jacek P.
Published: February 2024

Dry eye syndrome is one of the most common ocular chronic conditions that affects increasing number of patients worldwide. It is multifactorial disease with complex pathophysiology. However, inflammatory process seems to be a key factor in its vicious circle. Thus, every ophthalmologist should be aware of potential modes of its treatment. This review outlines wide variety of anti-inflammatory drugs approved for dry eye syndrome.
Astigmatism in the Context of Cataract Surgery with the Use of Toric Intraocular Lenses – Curent Literature Review
Authors: Gontarz Katarzyna , Dorecka Mariola , Mrukwa-Kominek Ewa
Published: February 2024

Assessment and management of astigmatism is often difficult, and one of the specific situations in which this problem must be faced is when a patient with astigmatism is qualified for cataract surgery. A relatively predictable method of astigmatism correction during a single procedure and also the method of choice in the treatment of cataracts accompanied by corneal astigmatism is cataract phacoemulsification with implantation of toric intraocular lenses. The aim of the study is to review the current literature on this topic.
The prevalence of corneal astigmatism ≥1.0 D in patients with cataract varies in various studies from 34.8 to 66.9%, which illustrates the scale of demand for this procedure. The paper discusses the key aspects of pre-operative assessment of astigmatism, including the changes that occur with the aging process. The importance of measuring the posterior corneal astigmatism and the consequences of its neglect in the form of deviations in the assessment of total corneal astigmatism and postoperative residual refractive errors were emphasized. Attention was paid to available updates of toric calculators and innovations in cases of irregular astigmatism.
Proliferative Diabetic Retinopathy with Bilateraloptic Disc Edema – Maintaining Near-normal Blood Glucose Values as a Gold Standard Treatment. Case Report
Authors: Sirek Sebastian , Jastrzębska-Miazga Irmina , Woś Rafał , Nocoń-Bratek Martyna , Mrukwa-Kominek Ewa
Published: February 2024

Introduction

One of the microvascular complications of diabetes mellitus is a diabetic retinopathy which turns out to be the main reason of newly developed blindness in individuals of reproductive age in developed countries.

Purpose

The aim of this study was to report a case of 23-years old patient which was provided with intensive therapy with the goal of achieving near-normal glycemia. Improved blood-glucose levels lead to inhibition and regression of diabetic retinopathy and improvement of visual acuity.

Results

Improvement of best corrected visual acuity of both eyes (righteye 0.8, left eye 0.7) was achieved. We observed significant improvement in clinical manifestations of diabetic retinopathy including regression of microvasular abnormalities and considerable reduction of optic disc edema.

Conclusions

Besides of invasive procedures such as laseroterapy, steroid or anti vascular endothelial growth factor injections and vitrecotmy, correct treatment of diabetes mellitus complications such as proliferative diabetic retinopathy should be mainly focused on maintaining normal blood-glucoselevels.
Therapeutic Approaches for Treatment of Diabetic Macular Edema
Authors: Post Michał , Polakowska Dorota , Wróbel-Dudzińska Dominika , Szaflik Jacek P.
Published: February 2024

Diabetic macular edema is an ocular complication of diabetes mellitus, leading to significant visual impairment. The pathogenesis of diabetic macular edema occurs through the interaction of multiple molecular mediators, including the overexpression of several growth factors, including vascular endothelial growth factor, angiopoietin-1, and -2, insulin-like growth factor-1, etc. These growth factors mediate endothelial cell proliferation, angiogenesis, protease production. Treatment for diabetic macular edema involves primary management of diabetes mellitus, laser photocoagulation, and pharmacotherapeutics targeting mediators, namely, the anti-vascular endothelial growth factor pathway. The introduction of anti-vascular endothelial growth factor therapies has resulted in significant clinical improvements compared to laser photocoagulation alone. However, the presence of anti-vascular endothelial growth factor non-responders and multiple factors influencing the visual outcome after anti-vascular endothelial growth factor treatment have necessitated the development of new therapeutic approaches. In this review, we provide an analysis of current management strategies to the treatment of diabetic macular edema
Chlorochine Retinopathy in COVID-19 Pandemic
Authors: Borowska Sława
Published: February 2024

Hydroxychloroquine (HCQ, Plaquenil) is used in treatment of a variety of autoimmune disorders, in dermatology, rheumatology and oncology. Hydroxychloroquine and chloroquine (CQ) have been associated with irreversible visual loss due to retinal toxicity. Hydroxychloroquine retinal toxicity is far more common than previously considered; an overall prevalence of 7.5% was identified in patients taking HCQ for greater than 5 years, rising to almost 20% after 20 years of treatment.
SARS-CoV-2 is a novel coronavirus that emerged in 2019 and is causing the COVID-19 pandemic. There is no current standard of care. Clinicians need to be mindful of the toxicity of a wide variety of possibly unfamiliar substances being tested or repurposed to treat COVID-19.
Micropulse Laser Therapy
Authors: Solarski Konrad , Świtka-Więcławska Iwona
Published: February 2024

Classical laser therapy has been used in ophthalmology with success for many years around the world. Due to the risk of developing complications, a new method of using lasers has been sought for many years. Subtreshold laser therapy, described below, is considered such a breakthrough.
Complications After Trabeculectomy and Current Strategies – Literature Review
Authors: Sobolewska Małgorzata , Mrukwa-Kominek Ewa
Published: February 2024

Glaucoma is the first cause of blindness in Europe and over the world. The purposes of its treatment are lowering intraocular pressure. For patients who have visual potential, conventional glaucoma surgery such as trabeculectomy is frequently performed. The most common failures of it are associated with functioning of the filtering bleb, which causes inappropriate filtration and ultimately hypotony or increased intraocular pressure. Prevention or good treatment of complications after trabeculectomy is necessary to achieve long-term success of anti-glaucoma surgery.
Drainage Devices in a View of Other Forms of the Treatment of Refractory Glaucoma
Authors: Cywiński Adam
Published: February 2024

Drainage devices have been using in the treatment of refractory glaucoma for more than 40 years. They give possibility for effective control of intraocular pressure in eyes, where natural outflow is totally blocked. Superiority of drainage systems such as Ahmed valve or Molteno device over other methods of normalization of intraocular pressure is due its effectiveness in eyes with high intraocular pressure and possibility of its use in eyes with higher risk of intraocular hemorrhage, which are observing ie. in patients with diabetic complications of the eye. A high intraocular pressure in eyes with increasing eye healing processes, mainly observed in children or in eyes with recurrent inflammation are contraindicated to treat using typical trabeculectomy procedure, because of its high ineffectiveness and therapy using diode laser should be recommended as a last choice of treatment of glaucoma. Proper diagnosis and the introduction of appropriate treatment methods at the right time significantly reduces the risk of vision loss due to glaucoma.
Treatment of a Congenital Lacrimal Sac Mucocele Using Endoscopic Techniques – a Case Report
Authors: Rogowska Anna , Kocyła-Karczmarewicz Beata , Tomaszewska Magdalena , Hautz Wojciech
Published: February 2024

Congenital lacrimal sac mucocele occurs in approximately 3% of infants with congenital lacrimal duct obstruction. Lacrimal sac mucocele is sometimes associated with a intranasal nasolacrimal duct cyst presenting as an intranasal cystic mass, which needs the involvement of an ophthalmologist and otolaryngologist in diagnosis and management. Bilateral cysts may cause in the early neonatal varying degrees of nasal obstruction, sleep disturbance, feeding difficulty and even respiratory distress. We present a case of bilateral dacryocystocoele with intranasal extension presenting as respiratory distress in a 7-day-old male newborn. The diagnosis was confirmed clinically and by computed tomography scan.
Rodas de conversa com adolescentes
Authors: Yaísa Gonçalves da Silva Cláudia , Fernandes da Motta Ivonise
Published: February 2024

Adolescentes em situação de risco pessoal ou social podem ser temporariamente encaminhados a instituições de acolhimento, como medida protetiva. O acolhimento institucional, ainda que seja um recurso de segurança, pode ter impactos ambivalentes no desenvolvimento emocional dos adolescentes. Este trabalho pretende divulgar uma pesquisa realizada com adolescentes do gênero feminino, residentes de um Serviço de Acolhimento Institucional para Crianças e Adolescentes, da cidade de São Paulo – SP, Brasil. Foram realizadas Rodas de Conversa temáticas com o intuito de conhecer a experiência emocional das participantes sobre o tema da esperança e da perspectiva de futuro sobre as próprias vidas. O material foi analisado pelo referencial teórico psicanalítico de D. W. Winnicott. Notou-se que o distanciamento social imposto pela pandemia de COVID-19 contribuiu para o estado de apatia, desânimo e abalo da esperança nas adolescentes. Contudo, a partir das intervenções grupais, foi possível resgatar a esperança e as expectativas positivas quanto ao futuro, por meio do estabelecimento de uma relação de confiança entre as participantes e a pesquisadora. Compreende-se que a esperança, ainda que esquecida, ainda habitava as participantes e pela via da comunicação do grupo, foi possível reacender a possibilidade de acreditar e colocar em movimento os planos de vida.
Compreender e reagir precocemente ao trauma infantil
Authors: Marans Steve
Published: February 2024

O autor aborda a aplicação dos princípios psicanalíticos nas situações de exposição à violência e ao trauma em muitas crianças afetadas por adversidades e questões sociais e de saúde púbica prementes. Segundo o autor os clínicos psicanalíticos estão em maior sintonia com o seu método quando aderem às tradições mais fundamentais de observar atentamente, esforçando-se por ver o mundo através dos olhos/experiência dos outros. Trabalhar na variedade de contextos em que as crianças em risco são atendidas proporcionou aos clínicos com formação psicanalítica a oportunidade de se aproximarem de fenómenos observáveis e em desenvolvimento que de outra forma não seriam vistos. Esta oportunidade levou ao desenvolvimento de novas opções para lidar com alguns dos resultados psíquicos e adaptativos de desafios esmagadores ao desenvolvimento progressivo e ótimo das muitas crianças afetadas por adversidades e situações traumáticas. Na situação de exposição à violência e ao trauma, a aplicação de princípios psicanalíticos também ofereceu às instituições e aos profissionais regularmente chamados e desafiados nas suas tentativas de responder às crianças afetadas alternativas ao afastamento/evitamento, que tão naturalmente ocorre face a situações esmagadoras de medo e desamparo. Foram utilizados e desenvolvidos recursos comunitários tais como o CFTSI, YCTSR e o CD-CP.
Uma imagem vale mais que mil palavras
Authors: Bouça Jorge
Published: February 2024

A tatuagem está presente na história Humana há, pelo menos, 4000 a 2000anos. A evolução da sua utilização ao longo do tempo é marcada por múltiplassignificações decorrentes do contexto social. A descoberta da fotografia no século XX,assim como as mudanças culturais, sociais, políticas e económicas ocorridas na segundametade do século XX e no século XXI, transformam radicalmente a visão e filosofia dautilização do corpo. A tatuagem adquire uma nova dinâmica como fonte de expressãode um mundo moderno onde a subjetivação se torna difícil, numa relação íntima semtempo. A exploração psicanalítica dos corpos tatuados conduz-nos à significaçãoinconsciente, fundada no Eu corporal, no Eu-pele, na relação precoce, nas dificuldadesde simbolização, na somatização e nos mecanismos de regressão. A necessidade deexteriorização dos conflitos internos e afirmação da individualidade na pele, oembelezamento constante de um corpo espetáculo, o controlo de angústias psicóticas,são algumas das funções que o ato de tatuar ou a modificação do corpo podem cumprir.São descritos alguns exemplos clínicos de autores de referência.
Perspectiva constitucional del proceso judicial y arbitral
Authors: Arrázola Jaramillo Fernando
Published: February 2024

El derecho procesal no es un asunto sencillo y en ocasiones
las complejidades del proceso pueden ser un gran reto para los intervinientes
en el debate, más aún cuando surgen conflictos de interpretación o aplicación
de normas constitucionales. El abogado de hoy debe comprender a cabalidad que
el derecho constitucional permea todas y cada una de las etapas del proceso
judicial y arbitral, y que el dominio de los principios y valores
constitucionales es una herramienta indispensable para el éxito de su gestión
profesional. Así, a lo largo de estas páginas el lector encontrará el análisis
de una serie de problemáticas actuales de naturaleza procesal y constitucional
de gran relevancia para la actuación judicial y que muestran las crecientes
tensiones existentes entre las normas legales que rigen el proceso y las normas
constitucionales. Escritos por experimentados docentes universitarios y
abogados litigantes, todos los capítulos analizan o interpretan las
problemáticas a la luz de fallos de tutela o de constitucionalidad proferidos
por la Corte Constitucional. Es la intención de los autores hacer un aporte
significativo con su trabajo a la literatura procesal colombiana.
DELINEAMENTOS DA NATUREZA JURÍDICA DO SELO DE FISCALIZAÇÃO NOTARIAL E REGISTRAL
Authors: Rausch Bonifácio Hugo
Published: February 2024

O presente artigo objetiva investigar a natureza jurídica do Selo de Fiscalização, cobrado junto dos emolumentos devidos pelos cidadãos que utilizam os serviços notariais e de registro no Estado do Rio Grande do Sul, tendo como destino o Fundo Notarial e Registral – FUNORE. Utilizou-se para a realização deste estudo técnicas pertinentes à pesquisa bibliográfica, avaliação da posição doutrinária acerca do tema, análise das atribuições conferidas ao Selo de Fiscalização pela Lei 12.692/06, especialmente na parte destinada a “prover outros serviços” do Tribunal de Justiça do Rio Grande do Sul (TJRS).
INTRODUÇÃO AO CONCEITO DE ENERGIA ELÉTRICA COM ESTUDANTES DO 5º ANO DE UMA ESCOLA PÚBLICA POR MEIO DO ENFOQUE CTS
Authors: Rosario Áquila Sabres de Oliveira , Ramos Elaine da Silva
Published: February 2024

O objetivo deste trabalho foi abordar o conceito de energia elétrica por meio do enfoque CTS com 28 estudantes do 5º ano de uma escola pública da cidade de Telêmaco Borba – PR, fazendo assim a inserção da Física nos anos iniciais, bem como trabalhando a consciência crítica dos estudantes. Para este trabalho utilizou-se como instrumento de coleta de dados registros em áudio e fotografia. A pesquisa tem caráter qualitativo e de pesquisa-ação. Buscou-se por meio da sequência trabalhada favorecer a dialogicidade dentro da sala de aula, bem como propiciando atividades com enfoque CTS para a produção de maior significado e contexto para os estudantes. A sequência foi trabalhada em 4 encontros (16 aulas). Os resultados mostram que a abordagem utilizada auxiliou para a aprendizagem dos estudantes, bem como despertou nos mesmos a reflexão acerca de questões ambientais. Houve interação e dialogicidade entre professora-aluno/aluno-aluno, sendo a professora o mediador no processo de ensino e aprendizagem. Pelos depoimentos dos estudantes acredita-se que passaram a se importar com questões como economia de água, de luz, preocupações com o meio ambiente. Propostas como esta deveriam estar mais presentes em aulas dos anos iniciais, pois assim estaríamos trabalhando com o gosto pela ciência desde cedo.
Estética intermediada en la performance Laboratorio de fantasmas. Una instalación multimedia de danza en el edificio Rialto de Valencia
Authors: Barberá-Pastor Carlos , León-Mendoza Raúl , Domingo-Muñoz Roser
Published: February 2024

El artículo analiza una práctica performativa llevada a cabo en el edificio Rialto de la ciudad de Valencia, en España, el 26 de noviembre de 2022. Dentro del Rialto, la sala 7 acoge artistas visuales, músicos y bailarines para producir un acontecimiento analizado desde una concepción intermedial. Las condiciones improvisadas de la performance; con sonoridades producidas por un piano, una guitarra, un bajo, una flauta travesera, y sonidos sintetizados y sampleados junto a videos procesados en tiempo real y proyectados en cenital sobre el suelo y una pantalla vertical; generan unos razonamientos sobre el esquema espacial en el que se llevó a cabo la acción performativa. La interdependencia de los cuerpos danzantes — espacio, sonido e imágenes proyectadas— lleva a estudiar el movimiento de la danza, prestando atención a la ocupación del espacio, que se articula claramente desde el centro de la sala. La argumentación de la performance nos lleva a vincularla con la ciudad, en el sentido diferencial entre el centro y periferia. El objetivo es investigar su sentido según ciertas conexiones entre la sala y la urbe. El trabajo concluye sobre la necesidad de redefinir el espacio de la performance y la importancia del análisis para su caracterización.
Incubación de iniciativas de la economía social solidaria
Authors: Arzadun Paula , Picado Arroyo Rytha
Published: February 2024

Las organizaciones de la economía social solidaria (ESS) surgen en el siglo XIX a través de figuras como cooperativas, mutuales y asociaciones, y se distinguen por la participación en su comunidad, la conciencia social y la solidaridad. Se trata de un campo de estudio caracterizado por su heterogeneidad y dinamismo, marcado por dos hitos temporales: pre y post era del Estado de Bienestar, considerando las diferentes realidades y respuestas de cada una de esas dos etapas. La incubación de empresas, por su parte, surge a mediados del siglo XX en Estados Unidos de América, expandiéndose posteriormente en el resto del mundo. Hay un consenso en la identificación de tres generaciones de incubadoras de empresa: la primera y segunda durante la década de los 80 y la tercera, a partir de la década de los 90 del siglo pasado. Si bien particularmente durante las últimas dos décadas se ha observado el florecimiento de prácticas que giran en torno a la incubación de iniciativas y de procesos asociativos, existen vacíos en lo que respecta a la investigación de modelos de incubación propiamente diseñados para el campo de la ESS. Por tanto, el presente artículo realiza un análisis bibliométrico para identificar conexiones entre la incubación y la ESS. A partir de los exiguos avances que se encuentran hasta este momento, el trabajo concluye con una propuesta de marco conceptual para la incubación de las iniciativas de la ESS, basado en la evidencia empírica sobre antecedentes, factores organizacionales y resultados.
Project management approaches and their selection in the digital age: Overview, challenges and decision models
Authors: Sommer Lutz
Published: February 2024

Digital transformation is a challenge that also impacts the selection of tools for implementing projects. Which tools are suitable for handling complex digital twins? Project management must respond to this with suitable approaches. The challenge for decision-makers is to choose the right one. Based on literature research and a case study, influencing factors are derived and practice-relevant project management approaches are collected. Furthermore, a decision model is developed that, on the one hand, supports the decision-maker in selecting tools before and during the project, and on the other hand makes empirical values from past projects usable for future decisions. The results show that the number of influencing factors is large, and the approaches are di-verse. In complex projects, this can lead to complex decision-making situations that require appropriate decision models. The developed “Supervised Decision Model – L5” is based on five levels (L): (L1) Building a database; (L2) Derivation of algorithms; (L3) Initial approach selection; (L4) Review of the initial selection; (L5) Using experiences for future decisions. In practice it turns out that complex projects – like Digital Twins - often fail. Modified decision models for selecting suitable approaches should therefore take the following as-pects into account: (a) decision-makers are actively supported in the initial decision phase; (b) initial decisions once made are checked in the early phase of the project and corrected if necessary; (c) the lessons learned are recorded in the database as empirical value and used for future decisions.
Tecnologias assistivas: formação, experiências e práticas
Authors:   Décio Nascimento Guimarães,   Douglas Christian Ferrari de Melo,   Jaime Ribeiro
Published: February 2024

O livro busca descrever as Tecnologias Assistivas e suas funcionalidades, bem como o contributo dessas tecnologias para qualidade de vida de uma pessoa que se vê perante uma limitação ou mesmo uma incapacidade.
Atendimento Educacional Especializado: fundamentos, formação e práticas pedagógicas
Authors:   Marcelo Loureiro Ucelli,   Alexandro Braga Vieira,   Reginaldo Celio Sobrinho
Published: February 2024

Os processos de escolarização de estudantes com deficiências, transtornos globais do desenvolvimento e altas habilidades/superdotação se fundamentam no direito social à educação mediada nas escolas comuns com apoio do Atendimento Educacional Especializado. Diante disso, nesta obra, afastamo-nos de concepções que colocam esses serviços como substitutivos ao trabalho curricular para reconhecê-lo como um conjunto de ações pedagógicas voltadas a apoiar a apropriação dos conhecimentos pelos alunos mencionados. Portanto, propusemo-nos a apresentar reflexões sobre os Fundamentos, a Formação Docente e as Práticas Pedagógicas em uma concepção de Atendimento Educacional Especializado que apoia a aprendizagem nas ações cotidianas escolares.
Pharmacopoeial Compliance of Marketed Formulations containing seeds of Syzygium cumini (L.) Skeels
Authors: Govindarajan Nartunai , Ravichandran Lokesh , Kumar Chelladurai Prem , Pandey Akansha , Murugesan Vendal , Kusuma Ganji
Published: February 2024

Background: The seeds of Syzygium cumini are extensively used in Ayurveda, Siddha and Unani (ASU) systems of medicine to treat diabetes, polyuria, diarrhoea and vomiting. As per classical literatures and Ayurvedic Formularies, the seed kernel is to be used in the formulations. In practice, the food and herbal drug manufacturers are incorporating the whole seed along with testa instead of seed kernel, as such sold in raw drug market. This may leads to reduction in potency of drug in formulations. Objective: The study was carried out to confirm the Pharmacopoeial compliance for seeds of S. cumini in marketed formulations Methods: Macro-microscopic studies were carried out by following standard methods of official books. Results: Macroscopically the whole seed and seed kernel can be differentiated by colour, appearance, size and shape. Microscopically the seed kernel can be differentiated from whole seed by absence of sclereids and fibres. Conclusion: The findings will be helpful to analyse the Pharmacopoeial compliance of marketed formulations containing seeds of S.cumini and to differentiate the seed kernel from testa. The studied marketed formulations of S. cumini seeds in powdered form were found to be noncompliance with Pharmacopoeial standards, since whole seed powder along with testa was found instead of seed kernel as recommended.
Potential of Indian herbs and herbs derived compounds in the treatment of Acne – A Commonly occurring skin disease: A Review
Authors: Biswas Poulomi , Biswas Kaushik
Published: February 2024

Acne, known as acne vulgaris, is said to be a recurrent disease related to the skin that becomes visible and the blockage of hair follicles becomes irresistible with skin cells that are supposed to be dead, bacteria, and sebum or oil. Hypersecretion of sebum in disrupted follicles can be considered for the pathogenesis of acne which leads to the formation of microcomedones. Inflammation occurs as the cause of hyperproliferation insisted by the follicles of microcomedones and comedones in both closed and open types. Then the appearance of pustules, papules, cysts, and nodules was observed. The aforementioned state of the skin with sebum or oil confinement is said to be a predisposed condition to the anaerobic growth of C. acnes. Various synthetic drugs are available for the treatment of acne but they are responsible for several adverse effects and show resistance of C. acnes to the available antibiotics. Plant parts or plant-derived compounds are traditionally used in the treatment of acne in India. Even today also a large section of the Indian population is using herbs to cure acne. So, the herbal agents derived from nature, have received considerable interest as they show hardly any detrimental effect and are cost-effective. This article aims to enumerate the role of a few Indian herbs such as Aloe vera, Azadirachta indica, Curcuma longa, etc. in the treatment of acne.
Hepatoprotective effect of Pippali Ghrita, an Ayurvedic Formulation against Anti-Tubercular Drug Induced Hepatotoxicity in Wistar Rats
Authors: K. Bhapkar Vedvati , L. Suryawanshi Nilesh , P. Gharote Archana , A. Pawar Vinay , Y. Chitrakar Mrudul
Published: February 2024

Combination chemotherapy of Isoniazid, Rifampicin, and Pyrazinamide is the preferred regimen for successful treatment of Tuberculosis (TB). The major complication of otherwise useful Anti-tubercular treatment (ATT) drugs is hepatic damage. There is lack of a definite effective treatment for the same in modern medicine. In view of this, the hepatoprotective activity of an Ayurvedic formulation, Pippali Ghrita (PG), was evaluated in anti-tubercular drug induced hepatotoxicity in Wistar rats. ATT drugs, viz., Isoniazid, Rifampicin, and Pyrazinamide were administered for 30 days to induce hepatotoxicity. Co-administration of PG in study group and Silymarin in standard control group was done for same duration. Hepatotoxicity was assessed on basis of ponderal parameters (body and liver weight) and biochemical parameters, viz., liver function parameters (Aspartate transaminase and Alanine transaminase), and oxidative stress parameters (Malondialdehyde and Superoxide dismutase). Results demonstrated significant increase in body weight and significant reduction in the liver weight, in study group and standard control group as compared to ATT control group. Likewise, significant reduction in liver function parameters and Malondialdehyde levels, with increase in Superoxide dismutase activity were observed, when compared to the ATT control group. The results indicated that co-administration of Pippali Ghrita for 30 days along with ATT prevented anti-tubercular drugs induced hepatotoxicity in Wistar rat model.
Correlation of Vitamin D Levels with Insulin Resistance in women with PCOS
Authors: Charles P T Siahaan Salmon , Idarto Areta , Hagia Lestari Sarah , Usman Fatimah , Aprianto Tannus Ferdinand
Published: February 2024

Polycystic Ovary Syndrome (PCOS) is a common endocrine disorder. Since PCOS impacts insulin metabolism and fertility, gene transcription and hormone regulation play a role in its development. The symptoms of PCOS, namely insulin resistance, ovulation, menstrual irregularities, infertility, hyperandrogenism, obesity, and an increase in the risk of cardiovascular disease can be worsen by decrement of 25(OH)D level. This study aimed to determine the phenotype distribution of PCOS; to know the levels of Vitamin D in women with PCOS; to know the picture of insulin resistance in women with PCOS with excess body weight; to analyze the relationship of Vitamin D with insulin resistance in women with PCOS. This study used analytical test with randomization on PCOS patients. The phenotypes of the study samples were phenotype 1 (6 patients = 30%) and phenotype 4 (14 patients = 70%), phenotypes 2 and 3 were not found; There was no relationship between vitamin D and insulin (12.635±4.2721 vs 11.407±4.2721; p= 0,068);There was no relationship between vitamin D and glucose (12.635 ±4.2721 vs 102.75±10.015; p= 0,835); There is a relationship between vitamin D and HOMA IR (12.635± 4.2721 vs 2.880±.4213; p = 0,026; r -0,497) with a negative correlation between the two variables and there is a relationship between BMI with HOMA-IR and vitamin D (p=0,001 and p= 0,003).There is a negative relationship between vitamin D and HOMA-IR, namely a decrease in vitamin D causes an increase in HOMA-IR (insulin resistance).
Whey preparation as an adjuvant to minimise the Intestinal inflammatory status in mucositis rat model
Authors: Reddy Sudarshan , M Rao Gayathri , Marathe Aradhana , Kamath Saritha
Published: February 2024

To study the effect of Whey Preparation on intestinal mucositis, model developed by administration of single dose of etoposide (60mg/Kg body wt., i.p). The experimental procedure included Adult albino rats (10±1 week old) of Wistar strain (n=30, 6/group). Freshly prepared whey preparation-(100 and 200mg/Kg/body wt.) was administered by orogastric gavage- Pre, both pre and post etoposide injection. Effectiveness of whey preparation was determined by estimating the biochemical parameters including intestinal Tumor Necrosis Factor-α, Interleukin-6, sodium potassium ATPase, inflammatory markers- Cyclooxygenase and Myeloperoxidase along with Nitric Oxide and reduced Glutathione with and without intervention after 72 hrs. of etoposide injection. There was a significant increase in the Tumor Necrosis Factor –α, Interleukin-6 levels and extent of apoptosis in etoposide controls. Etoposide administration caused a significant decreased the activity of Na+-K+ ATPase and reduced glutathione levels in intestinal tissue. However, in the post treatment groups, Tumor Necrosis Factor–α, Interleukin-6 as well as extent of apoptosis were reverted to normal after whey preparation administration.Whey Preparation gavage in both the study groups- pre and both pre and post etoposide exposure showed that intervention was able to preserve/ prevent changes in the biochemical activity. The results support the WP potentials to reduce the deleterious effects of etoposide on normal cells, which leads to mucositis.
Gênero e trabalho
Authors: Silva Mayco Lima da , Ferreira Laura Senna
Published: February 2024

Diante do aumento significativo da precarização do trabalho o empreendedorismo se propagou como alternativa para os trabalhadores. Para as mulheres, ele procurou representar um meio para o empoderamento e para a superação das tradicionais barreiras do mercado de trabalho. A presente pesquisa analisa a relação entre empreendedorismo, empoderamento e desigualdades de gênero no trabalho, indagando acerca do papel que o empreendedorismo ocupa na reprodução ou superação das desigualdades de gênero. Para tal, analisamos a partir de pesquisa documental um caso concreto onde a gestão empresarial aponta o empreendedorismo como meio para o empoderamento e para a superação das barreiras de gênero no mercado de trabalho. Concluímos que o empreendedorismo pode emergir como alternativa de sobrevivência e como meio de empoderamento individual, podendo promover algumas melhorias individuais em determinadas condições de vida, mas jamais como meio de empoderamento coletivo e de transformação das estruturas de poder.
Should We Embrace Impossible Worlds Due to the Flaws of Normal Modal Logic?
Authors: Eyinck Til
Published: February 2024

Some philosophers advance the claim that the phenomena of logical omniscience and of the indiscernibility of metaphysical statements, which arise in (certain) interpretations of normal modal logic, provide strong reasons in favour of impossible world approaches. These two specific lines of argument will be presented and discussed in this paper. Contrary to the recent much-held view that the characteristics of these two phenomena provide us with strong reasons to adopt impossible world approaches, the view defended here is that no such ‘knock-down arguments’ do emanate on those grounds. This is not to rule out that there cannot be any other good reasons for assuming impossible world semantics. However, the discussion of a further argument for impossible worlds will suggest that different attempts to argue for them likely present intertwined problems.
La tutela de los derechos de la personalidad ante atentados producidos en redes sociales y servicios equivalentes
Authors: Santos Morón María José
Published: February 2024

La gran cantidad de información que los usuarios de redes sociales y servicios equivalentes (v. gr. blogs, foros, etc.) vuelcan en internet, unida a la rápida difusión de lo publicado en el entorno digital, ha incrementado la posibilidad de que se lesionen los derechos de la personalidad del individuo. Para tutelar estos derechos el perjudicado puede acudir a distintas normas –como son, entre otras, la Ley Orgánica 1/82 de Protección al honor, la intimidad y la imagen, la Ley 34/2002 de Servicios de la Sociedad de la Información o la Ley Orgánica 3/2018 de Protección de Datos Personales y el Reglamento UE 2016/679– que ofrecen diversos mecanismos, judiciales y extrajudiciales, que este trabajo pretende analizar y sistematizar. Partiendo de un análisis jurisprudencial dirigido a constatar en qué casos puede cometerse una intro- misión ilegítima en los derechos al honor, la intimidad o la imagen de una persona como consecuencia de la publicación de contenidos en internet, se examinan las distintas herramientas que el perjudicado tiene a su disposición para reparar el derecho lesionado con el fin de determinar cuáles ofrecen más garantías o pueden ser, según los casos, de mayor utilidad.
Evolución jurisprudencial en materia de usura de las tarjetas de crédito revolving
Authors: Agüero Ortiz Alicia
Published: February 2024

Desde el año 2015 a esta parte, el TS ha dictado una pluralidad de sentencias en materia de usura de tarjetas de crédito revolving que ha comportado la desnaturalización de dicho control, al haber prescindido por completo de la ponderación de las circunstancias concurrentes. Así, provocó el paradójico resultado de que todas las tarjetas de crédito merecieran la consideración de usurarias, de suerte que el control de usura dejó de ser un control excepcional para ser predicable de todo un mercado. Con todo, desde 2022 se ha producido un viraje corrector en esta jurisprudencia, que ha establecido un criterio de usura con la finalidad de poner coto a las declaraciones de nulidad, la heterogeneidad de criterios y la inseguridad jurídica generada por sus primeros pronunciamientos. En el presente trabajo, pretendemos realizar un estudio jurisprudencial en materia de usura y, especialmente, en materia de usura del crédito revolving.
Lattante con inappetenza in Pronto Soccorso: una sfida per il pediatra
Authors: Leotta Michele , Cavallaro Paola , De Santis Antonella , Cioffi Speranza , Della Vecchia Nicoletta , Papini Laura , Cristaldi Sebastian , Musolino Anna Maria , Pisani Mara , Raucci Umberto , Villani Alberto
Published: February 2024

The authors describe the case of a 2-month-old inappetent infant finally diagnosed with a left diaphragmatic hernia.