bluuebunny/crossref_metadata_2025 huggingface dataset:
Approach of Analysis of Data Mining Prediction In Earthquake Case Using Non Parametric Adaptive Regression Method
Authors: Priyanto Dadang , Zarlis Muhammad , Mawengkang Herman , Efendi Syahril
Published: November 2020

Data Mining is the process of finding certain patterns and knowledge from big data. In general, the data mining process can be grouped into two categories, namely descriptive data mining and data mining prediction. There are several Math functions that can be used in the data mining process, one of which is the Classification and Regression function. Regression Analysis is also called Prediction analysis, which is a statistical method that is widely used to investigate and model relationships between variables. Regression analysis to estimate the regression curve can be done by analyzing Nonparametric Regression. One well-known method in non-parametric regression is MARS (Multivariate Adaptive Regression Spline). The MARS method is used to overcome the weaknesses of the Linear Regression method. The use of a stepwise backward algorithm with the CQP quadratic programming framework (CQP) from MARS resulted in a new method called CMARS (Conic Multivariate Adaptive Regression Splines). The CMARS method is able to model high dimensional data with nonlinear structures. The flexible nature of the CMARS model can be used in the process of analyzing earthquake predictions, especially in Lombok, West Nusa Tenggara. Test results Obtained a mathematical model of four independent variables gives significant results to the dependent variable, namely Peak Ground Acceleration (PGA). Contributions of independent variables are the distance of the epicenter 100%, magnitude 31.1%, the temperature of the incident location 5.5% and a depth of 3.5%.
Hostel Hostage Safety Application
Authors: D Gangai Aishwarya , I Hiremath Aishwarya , S Hotanahalli Akshata
Published: November 2020

Our project entitled as “Hostel Hostage Safety Application” is a web based application and also supports the android app and developed using .Net with C# technology. This app designed for the use by the Hostels where this application utilizes RFID Cards methodology that is implemented to record the in time and out time of the students from the hostel. Using RFID Cards we can track the students quickly and easily. This application helps the parents of their students who reside within the hostel to know every activity and attendance of their students within the hostel easily. This application also records the date and time of the visitors who visit the hostel. This application completely concentrates on security within the hostel and providing the safety to the residents who reside within their hostel.
A Secure and Fine-Grained Big Data Access Control Scheme for Cloud-Based Services
Authors: J William Nisha , O S Nisha
Published: November 2020

Cloud computing is the delivery of computing services including servers, storage, databases, networking, software, analytics, and intelligence over the Internet. Nowadays, access control is one of the most critical problems with cloud computing. Ciphertext-Policy Attribute Based Encryption (CP-ABE) is a promising encryption technique that enables end-users to encrypt their data under the access policies defined over some attributes of data consumers and only allows data consumers whose attributes satisfy the access policies to decrypt the data. In CP-ABE, the access policy is attached to the ciphertext in plaintext form, which may also leak some private information about end-users. Existing methods only partially hide the attribute values in the access policies, while the attribute names are still unprotected. This paper proposes an efficient and fine-grained big data access control scheme with privacy-preserving policy. Specifically, it hides the whole attribute (rather than only its values) in the access policies. To assist data decryption, it designs an algorithm called Attribute Bloom Filter to evaluate whether an attribute is in the access policy and locate the exact position in the access policy if it is in the access policy. The paper also deals with offline attribute guessing attack. Security analysis and performance evaluation show that this scheme can preserve the privacy from any LSSS access policy without employing much overhead.
A Study on Cryptographic Techniques
Authors: Krishna A Anjali , Manikandan L. C.
Published: November 2020

In current scenario, to store data securely on online is a tedious task as a result proper security over the network. Cryptography is a technique that masks the data over the channel of communication. Hiding the data to outsiders is an art. As the technology grows day by day, the need for data security over the channel of communication is greatly increased. Several cryptographic schemes are used for secure communication. The cryptographic technique and various algorithms are used to ensure the application has the necessary security. Cryptography is the science of both encryption and decryption. This paper describes all of the cryptographic techniques in detail.
Research on the Reform and Innovation of Vocal Music Teaching in Colleges
Authors: Fu Lei
Published: November 2020

The fundamental purpose of education is to promote better development of students. As the process of economic globalization accelerates, the teaching methods of art courses are also constantly improving. Especially in today's society with a high degree of tolerance, science and technology and the Internet have not only changed people's lives, but also changed the mode of thinking and learning. As an important front for transporting talents, the school pays more attention to strengthening the construction of student quality education and professional education service system. Obviously, the traditional education model can no longer meet the current social development's demand for high-quality talents. If we want students to achieve better development, we need to actively embrace the changes of the times, be student-oriented, follow the trend, and formulate educational policies that are more in line with the development of the times. Therefore, we need to make drastic reforms and innovations in vocal music teaching, and continuously improve the quality and level of vocal music teaching by reconstructing the teaching model. This article briefly describes the positive significance of the current college vocal music teaching reform and innovation, as well as the specific reform and innovation strategies for reference.
Aplikasi Mobile Pengaduan Kekerasan Dalam Rumah Tangga
Authors: Purnia Dini Silvi
Published: November 2020

Data on domestic violence (KDRT) sourced from the PPA symphony shows there were 12,185 reported domestic violence cases in 2018. Then in 2019 there were 6,009 reported domestic violence cases. Many cases of domestic violence that are not recorded and reported are caused by victims having difficulty in making complaints. Therefore, researchers designed a mobile-based complaint application that helps victims of domestic violence in the complaints process. In this study, researchers used a waterfall model software development method. This research resulted in a domestic violence complaint application that will facilitate victims to make complaints without having to come to the police station, so that the time needed is more efficient and effective.
Bio-informed Research in the Discipline of Architecture: A Bibliometric Analysis
Authors: Mutlu Avinç Güneş , Selçuk Semra Arslan
Published: November 2020

Bio-informed research reveals innovative, creative and original ideas for the solution to various problems in architectural design and many design disciplines. In the designs that adopt this approach, "nature" can be considered as a "data warehouse" providing various data that can be transferred from nanoscale to mesoscale regarding process, function, material, structure. Within the scope of this study, bibliometric research was carried out in the CumInCAD database to reveal what kind of information and outputs have been achieved through the data/capta taken from nature. In this process, the aim is to discover and understand the conceptual relationships, not only the purpose of the data taken from nature but also the relationships between the data and the patterns. All the data obtained were analysed within the scope of the determined parameters and visuals, including data relations, were prepared. As a result of the study, it can be seen that the bio-informed studies examined in this paper have the potential to open up a wide range of new research in the discipline of architecture. The findings show that the biomimetic approach has set the stage for the scientific and interdisciplinary studies that have the potential to change paradigms in architecture.
Effect of Insertion Viscoelastic Damping Layer with Different Thicknesses on the Dynamic Response of Multi-layered Beam in Forced Vibration
Authors: Baali Messaoud , Amrane Mohamed Nadir
Published: November 2020

In this work, we study the effect of the thickness variation of viscoelastic layer inserted in a laminated multi-layer beam in forced vibration on the vertical displacements and on the natural frequencies. The new structure is a sandwich structure composed by two external layers (top and bottom facesheets) of aluminum and viscoelastic core of 3M ISD112 polymers. The viscoelastic model used to describe the behavior of the core is a four-parameter fractional derivative model. The finite element method including the viscoelastic model of fractional derivatives for modeling the sandwich structure is used. The system resolution of the nonlinear equations of motion of the sandwich structure is required to use a numerical integration method as the explicit method of Newmark to obtain the transient response. Also, ANSYS finite element modeling is applied to the sandwich structure to calculate the frequency response in harmonic vibration. The increase in the thickness of the viscoelastic layer leads to a decrease in the amplitudes of vibration. The natural frequencies found by the two methods are very close to the frequencies found experimentally in the literature.
玻璃进深对门窗热工性能的影响
Authors: 吕 艳艳 , 袁 向东 , 林 忠仁 , 王 海龙 , 唐 浩
Published: November 2020

文章通过对比铝合金窗和铝包木窗配置的不同中空玻璃进深后的传热系数进行模拟计算和数据分析，总结玻璃进深对门窗传热系数的影响，同时对比使用不同玻璃进深后窗室内面温度的变化，总结中空玻璃进深对门窗结露性能的影响。
建设工程招标过程中存在的问题及改进措施
Authors: 黄 毅 , 张 莉
Published: November 2020

近年来，我国加大了对外经济开放的力度，从而促进了社会经济水平的显著提升，为各个行业的发展带来了良好的机遇。随着建设工程行业的不断发展，人们对工程招标工作越发的关注，招标制度的出台不但为建设工程企业在运营模式的创新创造了良好的基础，也使得建设工程企业管理机制不断的优化。早在上世纪80年代时，我国就逐渐的开始使用建设工程招标制度，其主要作用在于通过市场竞争挑选出最适宜的施工方，保证实现项目利益最大化的目标。经过实践调查我们发现，高品质的招标投标制度不但可以为工程各项工作的有序开展提供良好的辅助，而且可以从根本上对工程施工质量加以保障。但是，因为建筑市场还没有达到规范化的状态，再加上管理机制方面的缺失，从而造成了当前建设工程招标工作中存在诸多的问题。
Transfer of a Critically Ill Coronavirus Disease Patient: Transfer of Critical Covid-19 Patient
Authors: sulistio septo , Habib Hadiki , Mulyana Radi , Albar Imamul , Prabowo Yogi , Tjhia Jollis , Purawijaya Handrian
Published: November 2020

Coronavirus disease (COVID-19) is an infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Acute respiratory distress syndrome (ARDS) is a feature of SARS-CoV-2, and transferring patients with severe ARDS is challenging owing to their condition and risk of infection during the transfer process.

The hemodynamic instability of critically ill patients adds to the challenge of safe transfer, which requires thorough preparation of personnel, medication, equipment, and communication and transport methods, all of which must be organised within the infection control framework.

In this case report we discuss a woman, 37 years of age, with suggested COVID-19, intubated due to severe ARDS. Owing to the hospital referral policy in Indonesia, the patient was transferred to a specialist infectious disease hospital by land ambulance, with a special transfer team formed to adhere to infection control protocols and critical patient transfer procedures.
Sosialisasi Pemanfaatan Air Hujan dengan Pembuatan Sumur Resapan Untuk Penanggulangi Banjir/Genangan dan Konservasi Air Tanah di SMP Negeri 8 Menteng Jakarta Pusat
Authors: Lestari Endah
Published: November 2020

In recent years floods and droughts have occurred in various places in Indonesia. Java is one of the islands that often experiences flooding. During the rainy season floods cause several major cities to be submerged. Jakarta was hit several times by severe flooding. Flood events that occurred in 2007 caused approximately 60% of the DKI area to be submerged by a depth of more than 5 meters. PKM Partners is a public junior high school building located in Menteng, Central Jakarta. The Mitra area in the last few years has experienced a flood, it is quite disturbing the teaching and learning process in the Mitra area. The clean water crisis also occurs in the Mitra area, this is due to the location of the Mitra which is quite close to office buildings that have large enough water needs.

The average rainfall in Indonesia is 2779 mm per year, in Jakarta around 2500 mm per year, with 180 days / year of rainy days. With a large enough rainfall average is the potential of water resources that can be utilized optimally. With the potential of existing water resources, it is necessary to have efforts to utilize water resources, especially rainwater, one of which is by making water infiltration techniques into the ground in the form of infiltration wells. Through this outreach activity, it is hoped that it can develop public awareness on how to tackle flooding on a small scale, namely at the household level to a wider level, schools, office buildings, etc. by using infiltration well technology in handling floods. and groundwater conservation.
Sosialisasi dan Instalasi Panel Surya Sebagai Energi Terbarukan Menuju Kesadaran Lingkungan Indonesia Bebas Emisi
Authors: Kinasti RR Mekar Ageng , Putri Desi , Lestari Endah , Sofyan Muhammad , Kustanrika Irma Wirantina , Hidayawanti Ranti , Sangadji Iriansyah BM
Published: November 2020

Perubahan iklim yang terjadi saat ini sebagai dampak ketidakeimbangan tingkat CO2 di atmosfer sebagai emisi dari penggunaan energi berbahan baku karbon serta prediksi kebutuhan akan energi dimasa depan, serta meningkatnya biaya pemenuhan kebutuhan listrik berbahan fosil terkait dua alasan yang melatarbelakangi Program Kemitraan Masyarakat ( PKM) ini dilakukan. PKM ini dilakukan dengan memberikan sosialisasi kepada masyarakat tentang pemanfaatan sel surya sebagai sumber energi alternatif yang sangat dekat dengan kehidupan kita setiap harinya, serta latar belakang perlunya kita mempergunakan energi alternatif tersebut di harapkan mampu membuka wawasan sekaligus memberikan motivasi kepada pihak Mitra untuk melakukan pengembangan pemanfaatannya sebagai bentuk kepedulian kita  terhadap masa depan bumi yang akan datang. Dengan sampainya informasi pemutakhiran serta penerapannya kepada masyarakat, hal tersebut dapat memotivasi Mitra untuk mengembangkan pemanfaatan panel surya di SMPN 462 dengan lebih baik sehingga dapat menjadi sekolah yang mandiri dalam memenuhi kebutuhan energi listrik di sekolah tersebut. Optimalisasi tujuan PKM memerlukan keseriusan serta kepedulian dari berbagai lapisan elemen masyarakat seperti tim pelaksana, institusi tim pelaksana, serta pihak Mitra guna meningkatkan kesejahteraan kehidupan bermasyarakat serta turut menjaga  kelestarian lingkungan hidup menuju Indonesia Bebas Emisi.

Kata Kunci : panel surya, sel surya, energi alternatif, energi terbarukan, penyelamatan lingkungan hidup
Pelatihan Instalasi Penerangan Untuk Mahasiswa Teknik Elektro
Authors: Kurniasih Novi
Published: November 2020

The training of lighting installations for electrical engineering students is intended to provide an understanding of the electricity dangers and skills in terms of installing lighting installations that comply with PUIL standards. With the training of this lighting installation, it can help electrical engineering students to install and repair electrical installations independently even with having these skills can make those students open business opportunities so that employment opportunities will be open and at least they will have income for themselves. This training is given in two stages, namely the stage of supply material and the material testing phase, both theoretically and practically. With this training, the trainees are expected to understand well about the electricity dangers and how to secure it, read installation drawings, measure voltage, detect broken connections, and can make lighting installations using various switches and sockets that comply with the standards and conditions in PUIL and SPLN. In designing and installing electrical installations systems must be considered about human safety, other living things and the security of property from harm and damage that can be caused by the use of electrical installations. Through the Community Partnership Program, electrical engineering lecturer team of IT–PLN felt to need to conduct community training which is currently only focused on electrical engineering students of Pertamina University, by providing knowledge about lighting installation engineering skills. By utilizing experts in the electrical engineering department of IT–PLN, it is expected to be able to add skills and knowledge to electrical engineering students of Pertamina University. The trainees are expected to have an understanding of the electricity theory, the dangers of electricity and how to deal with it and have a strong desire to obtain theoretical and practical knowledge about electrical lighting installation techniques.
Perancangan Pemanfaatan Pompa Air Tenaga Surya Untuk Sumber Air Bersih Desa Sukarame, Kec. Sajira, Banten
Authors: Simamora Yoakim
Published: November 2020

Water requirements for the people in sukarame village, Sajira, for daily needs in the dry season tend to increase, They always experience drought for 6-9 months annually. The people independently built water reservoirs from mountain water sources. Water is pumped using a water pumping machine and accommodated in reservoirs, then distributed to local residents through pipes with minimum distribution distance is 1 km from the reservoir. Because the distance between water sources and the people complaining about clean water does not reach their homes. This problem can be done by building a ground well located not far from the house of the community, so that the distance between the source of clean water and the house of the community is not too far, water from the water source  will be accommodated in reservoirs by sucking ground water using a solar water pump so residents are not burdened with electricity fees to suck ground well water into clean air tendons. This design is expected to provide a solution for clean water sources for volunteers in the village of Sajira.
Exemption of behind-the-wheel driving test for novice young drivers: A serious public health concern
Authors: Bari Imran , Paichadze Nino , Hyder Adnan
Published: November 2020

Road traffic injuries (RTIs) continue to emerge as a serious public health issue across the world; according to the World Health Organization, every year, almost 1.35 million individuals lose their lives, and approximately 25 million injuries are caused by road traffic crashes (World Health Organization, 2018). These RTIs are the leading cause of death for children and young adults between 5-29 years of age (World Health Organization, 2018).

Under the current situation of COVID-19 pandemic, there have been reports suggesting a profound decline in RTIs because of reduced traffic on the world’s roads (Job, 2020); however, amid this pandemic, some states in the United Sates have proposed controversial road traffic policies that can jeopardize road safety. The Governor of the State of Georgia, the United States, recently, through an executive order, waived the behind-the-wheel road test requirement for novice drivers who had held a driving permit for a year (The State of Georgia Government, 2020). Through this wavier, almost 20,000 teenagers were granted full driving privileges last month (Taylor, 2020). While the decision was made to address the backlog of driving tests created by the COVID-19 pandemic, and also to practice social distancing (Taylor, 2020), many public health experts are now concerned that this decision will have catastrophic consequences on road safety.
Çalışmada Akış Deneyimi Ölçeğinin (ÇADÖ) Türkçe Uyarlaması: Geçerlik ve Güvenirlik Çalışması
Authors: TURAN Nuray , PALA Osman
Published: November 2020

Bu araştırmanın amacı, 2008 yılında Bakker tarafından geliştirilen Çalışmada Akış Deneyimi Ölçeği (ÇADÖ) Türkçe formunun geçerlilik ve güvenirliğini test etmektir. Çalışmanın örneklemini, 135 akademisyen ve 117 öğretmen oluşturmaktadır. Elde edilen sonuçlara göre ölçeğin iki boyutlu bir yapıya sahip olduğu tespit edilmiştir. Bu boyutlardan orijinal ölçekte yer alan “çalışmaya kendini verme” boyutu bu çalışmada aynı sonucu vermiş; “çalışmadan keyif alma” ve “içsel çalışma motivasyonu” boyutları ise, orijinal ölçekten farklı olarak tek boyutta birleşmiştir. Birleşen iki boyuttan oluşan bu yeni boyut “çalışmada içsel keyif” olarak adlandırılmıştır.Sonuç olarak, ölçeğin bu haliyle farklı sektörlerde ve örneklemlerde çalışmada akış deneyimi yaşama hakkında çalışma yaşamına dair çıkarımlarda bulunabilmek için yararlı olacağı düşünülmektedir. Ayrıca, bu ölçeğin, gelecekte farklı araştırmalarda bağımlı ve bağımsız değişken olarak kullanılması önerilmektedir.
Recognition of the Indigeneity of the Basarwa in Botswana: Panacea against their Marginalisation and Realisation of Land Rights?
Authors: Mogomotsi Goemeone E. J. , Mogomotsi Patricia K.
Published: November 2020

The Basarwa are the most marginalised tribe in Botswana. Their loss of access to land and subjugation is traceable to the arrival of the Bantu in Southern Africa. In an effort to address this historical injustice, the colonial government conceived the Central Kalahari Game Reserve (CKGR) as a ‘Bushmen’ land reserve. Notwithstanding this, the Basarwa have lost access to their historical lands and natural resources to tourism and mining. Consequently, the Basarwa took the government to court which resulted in the judicial pronouncement that that they are lawful occupiers of the reserve and cannot be relocated against their will. The court ruled that the Basarwa are indigenous peoples within the scope of international law. This article investigates the rights indigenous peoples have in the context of protecting the Basarwa. It argues that the Constitution of Botswana confers special rights to the Basarwa equivalent to those of indigenous peoples at international law. It further argues that the Basarwa have rights to access and utilisation of natural resources in the CKGR. This article recommends that the government should desist from approaching the Basarwa in a paternalist manner and respect their right to self-determination. It concludes that the recognition of the indigeneity of the Basarwa is critical in resolving their land issues.
Solid Polymer Electrolytes Derived from Oligomeric Poly(ethylene oxide) Chain-Grafted Crosslinked Polystyrene Microspheres
Authors: Zhao Wendy , Mei Xinyi , Yue Zheng , Mandal Braja K
Published: November 2020

A new class of lithium-ion conducting Solid Polymer Electrolytes (SPEs) has been derived from oligomeric Polyethylene Oxide (PEO)-grafted Cross-linked Polystyrene (XPS) microspheres containing one or two lithium sulfonamide moieties. The SPE containing Li:O mole ratio of 1:8 displayed excellent ionic conductivity (in excess of 10-4S/cm at 25ºC) and good electrochemical stability (4.3 volts versus Li/Li+). Thermal properties of these SPEs have also been investigated with Differential Scanning Calorimetry (DSC) and Thermogravimetric Analysis (TGA). These new SPEs possess amorphous character with a glass Transition Temperature (Tg) around 135ºC, and no significant thermal decomposition until 420ºC. Synthesis and characterization including surface morphologies of these SPEs are described.
Pharmacological Effects of Salvianolic Acid B Against Oxidative Damage
Authors: Xiao Zhun , Liu Wei , Mu Yong-ping , Zhang Hua , Wang Xiao-ning , Zhao Chang-qing , Chen Jia-mei , Liu Ping
Published: November 2020

Salvianolic acid B (Sal B) is one of the main active ingredients of Salvia miltiorrhiza, with strong antioxidant effects. Recent findings have shown that Sal B has anti-inflammatory, anti-apoptotic, anti-fibrotic effects and can promote stem cell proliferation and differentiation, and has a beneficial effect on cardiovascular and cerebrovascular diseases, aging, and liver fibrosis. Reactive oxygen species (ROS) include oxygen free radicals and oxygen-containing non-free radicals. ROS can regulate cell proliferation, survival, death and differentiation to regulate inflammation, and immunity, while Sal B can scavenge oxygen free radicals by providing hydrogen atoms and reduce the production of oxygen free radicals and oxygen-containing non-radicals by regulating the expression of antioxidant enzymes. The many pharmacological effects of Sal B may be closely related to its elimination and inhibition of ROS generation, and Nuclear factor E2-related factor 2/Kelch-like ECH-related protein 1 may be the core link in its regulation of the expression of antioxidant enzyme to exert its antioxidant effect. What is confusing and interesting is that Sal B exhibits the opposite mechanisms in tumors. To clarify the specific target of Sal B and the correlation between its regulation of oxidative stress and energy metabolism homeostasis will help to further understand its role in different pathological conditions, and provide a scientific basis for its further clinical application and new drug development. Although Sal B has broad prospects in clinical application due to its extensive pharmacological effects, the low bioavailability is a serious obstacle to further improving its efficacy in vivo and promoting clinical application. Therefore, how to improve the availability of Sal B in vivo requires the joint efforts of many interdisciplinary subjects.
Significance of Medicinal Mushrooms in Integrative Oncology: A Narrative Review
Authors: Jeitler Michael , Michalsen Andreas , Frings Daniela , Hübner Marisa , Fischer Moritz , Koppold-Liebscher Daniela A. , Murthy Vijay , Kessler Christian S.
Published: November 2020

Medicinal mushrooms are widely used in East Asia for the treatment of various diseases, especially in complementary cancer care. While there is a growing interest in medicinal mushrooms in Western countries and an increasing number of pre-clinical studies indicate distinct anti-cancer and regenerative properties, little is known about their potential relevance for clinical practice. This review aims to provide an overview of the clinical evidence, significance and potential role of medicinal mushrooms in complementary cancer care. Scientific databases for (randomized) controlled clinical trials evaluating whole spectrum formulations of medicinal mushrooms (mushroom powder and mushroom extracts) in cancer patients during and/or after conventional oncological treatment were searched. Eight studies met our inclusion criteria (eight randomized controlled trials, one controlled clinical trial). The medicinal mushrooms investigated were Agaricus sylvaticus (two trials), Agaricus blazei murill (two trials), Antrodia cinnamomea (one trial), Coriolus versicolor (one trial) and Ganoderma lucidum (three trials); all were compared to placebo and administered orally. A variety of cancer entities, outcomes and treatment durations were observed. Study results suggested beneficial effects of medicinal mushrooms, particularly quality of life and reduction of adverse effects of conventional therapies. Also, positive effects on antitumor activity and immunomodulation were reported, e.g., an increased activity of natural killer cells. In addition, results might suggest a longer survival of cancer patients receiving mushroom preparations, although in most studies this was not significant when compared to placebo. Adverse events of treatment with medicinal mushrooms were poorly reported; gastrointestinal reactions and a decrease in platelet cell count occurred in some cases. The methodological quality of most studies was generally unsatisfying and most results were insufficiently reported in several respects. Medicinal mushrooms may have a therapeutic potential for cancer patients during and after conventional oncological care with regards to quality of life, reduction of adverse effects of conventional care and possibly other surrogate parameters like immune function. There is an urgent need to investigate the safety and possible interactions of medicinal mushrooms. High-quality clinical research is warranted in order to clarify the potential of medicinal mushrooms in cancer therapy.
External Validation of a Nomogram and Risk Grouping System for Predicting Individual Prognosis of Patients With Medulloblastoma
Authors: Guo Chengcheng , Yao Dunchen , Lin Xiaoping , Huang He , Zhang Ji , Lin Fuhua , Mou Yonggao , Yang Qunying
Published: November 2020

Background: Medulloblastoma (MB) is one of the most malignant neuroepithelial tumors in the central nervous system. This study aimed to establish an effective prognostic nomogram and risk grouping system for predicting overall survival (OS) of patients with MB.

Materials and Methods: The nomogram was constructed based on data from the database of Surveillance, Epidemiology, and End Results (SEER). This database consisted of 2,824 patients with medulloblastoma and was used as the training cohort. The data of another additional 161 patients treated at the Sun Yat-sen University Cancer Center (SYSUCC) were used as the external validation cohort. Cox regression analysis was used to select independent prognostic factors. Concordance index (C-index) and calibration curve were used to predict the prognostic effect of the nomogram for overall survival.

Results: In the training cohort, Cox regression analyses showed that the prognostic factors included histopathology, surgery, radiotherapy, chemotherapy, tumor size, dissemination, and age at diagnosis. The internal and external validated C-indexes were 0.681 and 0.644, respectively. Calibration curves showed that the nomogram was able to predict 1-, 3-, and 5-year OS for patients with MB precisely. Using the training cohort, a risk grouping system was built, which could perfectly classify patients into four risk nomogroups with a 5-year survival rate of 83.9%, 76.5%, 64.5%, and 46.8%, respectively.

Conclusion: We built and validated a nomogram and risk grouping system that can provide individual prediction of OS and distinguish MB patients from different risk groups. This nomogram and risk grouping system could help clinicians making better treatment plan and prognostic assessment.
The Self and Its Nature: A Psychopathological Perspective on the Risk-Reducing Effects of Environmental Green Space for Psychosis
Authors: Ebisch Sjoerd J. H.
Published: November 2020

Epidemiological studies have shown that environmental green space contributes to the reduction of psychosis incidence in the population. Clarifying the psychological and neuro-functional mechanisms underlying the risk-decreasing effects of green surroundings could help optimize preventive environmental interventions. This perspective article specifically aims to open a new window on the link between environmental green space and psychosis by considering its core psychopathological features. Psychotic disorders, such as schizophrenia, are essentially characterized by self-disturbances. The psychological structure of the self has been described as a multidimensional phenomenon that emerges from the reciprocal interaction with the environment through intrinsic and extrinsic self-processes. The intrinsic self refers to the experience of mental activity and environmental information as inherently related to one’s own person, which involves self-referential processing, self-reflection, memory, interoception, and emotional evaluation. The extrinsic self refers to sensorimotor interactions with the environment and the sense of agency, that is, the experience of being the source of one’s own actions and the multisensory consequences thereof. In psychosis, anomalous self-processing has been related to a functional fragmentation of intrinsic and extrinsic self-processes and related brain networks. Moreover, evidence from cognitive neuroscience suggests that green space could have beneficial effects on self-related processing. Based on the literature, it could be hypothesized that self-processing is involved in mediating the beneficial effects of green space for psychosis. Considering the multidimensionality of the self, it is proposed that urban green space design aimed at improving mental health ideally impacts the complexity of self-facets and thus restores the individual’s self.
Supporting Double Duty Caregiving and Good Employment Practices in Health Care Within an Aging Society
Authors: Detaille Sarah I. , de Lange Annet , Engels Josephine , Pijnappels Mirthe , Hutting Nathan , Osagie Eghe , Reig-Botella Adela
Published: November 2020

Background: Due to the aging society the number of informal caregivers is growing. Most informal caregivers are women working as nurses within a health organization (also labeled as double-duty caregiver) and they have a high risk of developing mental and physical exhaustion. Until now little research attention has been paid to the expectations and needs of double duty caregivers and the role of self-management in managing private-work balance.

Objective: The overall aim of this study was to investigate the expectations and needs of double duty caregivers in Netherlands, and to examine the meaning of self-management in managing work-life balance.

Method: Different research methods have been applied in this exploratory study. Firstly, a scoping review has been conducted on the topics self-management and sustainable employability of double-duty caregivers using the search engines: CINAHL, MEDLINE, PubMed, and Google Scholar. Furthermore, a qualitative study has been conducted through focus groups with double duty caregivers.

Results: Twenty studies that met the inclusion criteria (i.e., nurses with double duty caregiving tasks) could be identified. We found that double duty caregivers have different motivations for being a double duty caregiver based on internal and external expectations. Double duty caregiving causes a lot of mental and physical pressure for the caregiver. To be able to combine both duty’s, double duty caregivers need flexibility and understanding from the workplace. Through two focus groups (N = 17) we found that social support from the workplace is not enough to be able to manage the situation. Self-management skills are important to be able to communicate effectively with the workplace and community care organizations about the kind of support needed. Also, health care organizations should offer the same support to double duty caregivers as any other informal caregiver.

Discussion: Double-duty caregivers are at high risk of developing symptoms of overload and risk of reduced self-management quality and employability levels across time. Health care organizations and the double duty caregiver often wait too long to act instead of taking more preventive measures. Furthermore, community care organizations should dialog with double duty caregivers about their wishes concerning the division of caring tasks. This finding calls for special attention, with long-term solutions at both macro (health-care level), organizational (meso-level), and employee level (micro level).
Discovery of 12O—A Novel Oral Multi-Kinase Inhibitor for the Treatment of Solid Tumor
Authors: Fan Yan , Huang Zhi , Wang Xiaoshuang , Ma Yakun , Li Yongtao , Yang Shengyong , Shi Yi
Published: November 2020

A novel series of pyrimidine-benzotriazole derivatives have been synthesized and evaluated for their anticancer activity against human solid tumor cell lines. The most promising molecule 12O was identified for its excellent antiproliferative activities, especially against the SiHa cell line with IC50 value as 0.009 μM. Kinase inhibition assay assessed 12O was a potential multi-kinase inhibitor, which possessed potent inhibitory activities against cyclin-dependent kinases (CDKs) and fms-like tyrosine kinase (FLT) with IC50 values in the nanomolar range. Molecular docking studies illustrated that the introduction of triazole moiety in 12O was critical for CDKs inhibition. In addition, 12O inhibited cancer cell proliferation, colony-formation, and cell cycle progression and provoked apoptotic death in vitro. In an SiHa xenograft mouse model, a once-daily dose of compound 12O at 20 mg/kg significantly suppressed the tumor growth without obvious toxicity. Taken together, 12O provided valuable guide for further structural optimization for CDKs and FLT inhibitors.
Overcoming the Biological Contamination in Microalgae and Cyanobacteria Mass Cultivations for Photosynthetic Biofuel Production
Authors: Zhu Zhi , Jiang Jihong , Fa Yun
Published: November 2020

Microalgae and cyanobacteria have shown significant potential for the development of the next biofuels innovation because of their own characteristics as photosynthetic microorganisms. However, it is confronted with a lot of severe challenges on the economic scaling-up of the microalgae- and cyanobacteria-based biofuels production. One of these major challenges is the lack of a reliable preventing and controlling culture system of biological contamination, which can attack the cell growth or product accumulation causing crashing effects. To increase the commercial viability of microalgae- and cyanobacteria-based biofuels production, overcoming the biological contaminations should be at the top of the priority list. Here, we highlight the importance of two categories of biological contaminations and their controlling strategies in the mass cultivations of microalgae and cyanobacteria, and outline the directions that should be exploited in the future.
Circulating Ligands of the Receptor for Advanced Glycation End Products and the Soluble Form of the Receptor Modulate Cardiovascular Cell Apoptosis in Diabetes
Authors: Tsoporis James N. , Hatziagelaki Erifili , Gupta Sahil , Izhar Shehla , Salpeas Vasileos , Tsiavou Anastasia , Rigopoulos Angelos G. , Triantafyllis Andreas S. , Marshall John C. , Parker Thomas G. , Rizos Ioannis K.
Published: November 2020

We determined whether plasma concentrations of the receptor for advanced glycation end products (RAGE) and the soluble (s) form of RAGE (sRAGE) in healthy individuals and patients with type 2 diabetes (T2D) modulate vascular remodeling. Healthy individuals and patients with T2D were divided into two age groups: young = <35 years old or middle-aged (36–64 years old) and stratified based on normal glucose tolerance (NGT), impaired (IGT), and T2D. Plasma titers of sRAGE, the RAGE ligands, AGEs, S100B, S100A1, S100A6, and the apoptotic marker Fas ligand Fas(L) were measured by enzyme-linked immunosorbent assay (ELISA). The apoptotic potential of the above RAGE ligands and sRAGE were assessed in cultured adult rat aortic smooth muscle cells (ASMC). In NGT individuals, aging increased the circulating levels of AGEs and S100B and decreased sRAGE, S100A1 and S100A6. Middle-aged patients with T2D presented higher levels of circulating S100B, AGEs and FasL, but lower levels of sRAGE, S100A1 and S100A6 than individuals with NGT or IGT. Treatment of ASMC with either AGEs or S100B at concentrations detected in T2D patients increased markers of inflammation and apoptosis. Responses attenuated by concomitant administration of sRAGE. In middle-aged patients with T2D, lower circulating plasma levels of sRAGE may limit decoy and exogenous trapping of deleterious pro-apoptotic/pro-inflammatory RAGE ligands AGEs and S100B, increasing the risk for diabetic complications.
Bio-Degradable Polyurethane Foams Produced by Liquefied Polyol from Wheat Straw Biomass
Authors: Serrano Luis , Rincón Esther , García Araceli , Rodríguez Jesús , Briones Rodrigo
Published: November 2020

In the present work, an abundant and unused residue (wheat straw) has been employed to synthesize a polyol as a substituent of castor oil in polyurethane foams. The liquefied product showed excellent properties for the proposed application. Castor oil was substituted with up to 50% wheat straw polyol in the formulation of polyurethane foams, which were prepared using two different isocyanates (methylene diphenyl diisocyanate (MDI) and toluene-2,4-diisocyanate (TDI)). The evaluation of physical, mechanical, and thermal properties of the foams revealed that these materials can successfully be formed with up to 40% wheat straw polyols since all the results were improved. Moreover, at this polyol concentration, the morphology of the foams was presented as a compact and ordered structure. Following this trend, the foams showed excellent biodegradability at 30 days (5.60 and 7.31% for TDI and MDI foams, respectively) and 60 days (8.49 and 9.88% for TDI and MDI foams, respectively) in the soil media tests carried out. Thus, the materials prepared in this work can be proposed for agricultural applications such as use in plant nurseries.
Diamond B23 CD Imaging of Thin Films of Chiral Materials or Achiral Polymers Coated with Chiral Molecules
Authors: Hussain Rohanah , Jávorfi Tamás , Hughes Charlotte S , Sriram Harini , Lashminarayanan Rajamani , Siligardi Giuliano
Published: November 2020

The novel vertical sample chamber, developed at the B23 beamline for synchrotron radiation circular dichroism (SRCD), has enabled the Diamond User community to conduct different types of experiments from high throughput CD of protein and DNA folding using 96-well multiplates to CD imaging at high spatial resolution. Here, we present the application of CD imaging to large areas of achiral polymer PVA films doped with D-dopa to assess the chiral homogeneity of the film preparation with potential antimicrobial property. Synopsis: CDi application of Diamond B23 SRCD beamline.
Deformed Shape Invariant Superpotentials in Quantum Mechanics and Expansions in Powers of ℏ
Authors: Quesne Christiane
Published: November 2020

We show that the method developed by Gangopadhyaya, Mallow, and their coworkers to deal with (translational) shape invariant potentials in supersymmetric quantum mechanics and consisting in replacing the shape invariance condition, which is a difference-differential equation, which, by an infinite set of partial differential equations, can be generalized to deformed shape invariant potentials in deformed supersymmetric quantum mechanics. The extended method is illustrated by several examples, corresponding both to ℏ-independent superpotentials and to a superpotential explicitly depending on ℏ.
Skip the Dip—Avoid the Risk? Integrated Microbiological Water Quality Assessment in the South-Eastern Baltic Sea Coastal Waters
Authors: Gyraite Greta , Kataržytė Marija , Overlingė Donata , Vaičiūtė Diana , Jonikaitė Eglė , Schernewski Gerald
Published: November 2020

The bathing water microbiome consists of pathogenic and non-pathogenic microorganisms, such as bacteria, viruses, and protozoa. However, the targets of the Bathing Water Directive (2006/7/EC) focus exclusively on fecal pollution. This study aims to investigate fecal indicator bacteria (FIB), naturally thriving cyanobacteria, and Vibrio bacteria in the Lithuanian coastal Baltic Sea and Curonian Lagoon bathing sites, combining information into an integrated microbial risk assessment scheme. The results show that officially monitored indicators, such as FIB, do not exceed the acceptable ‘low’ risk threshold. Simultaneously, cyanobacteria and Vibrio cholerae abundance in the Curonian Lagoon sites reveal a ‘high’ probability of adverse health effects. In coastal bathing sites, a positive correlation was found between Escherichia coli, cyanobacterial harmful algae bloom (cHAB), and V. cholerae, indicating that all target microorganisms may occur at the same time, with consequently high risks for the health of bathers. Therefore, implementing new target organisms in national or even regional bathing water monitoring programs is recommended, in order to safeguard the health of beachgoers.
UM OLHAR SOBRE A FORMAÇÃO CONTINUADA DE PROFESSORES NA REDE MUNICIPAL DE RECIFE/PE
Authors: Lopes Mario Marcos , Rodrigues Costa Luiza Maria
Published: November 2020

O presente estudo investiga o processo de formação continuada na Rede Municipal de Recife. Teve como objetivo geral, verificar os impactos da formação continuada de professores na Rede Municipal de Ensino de Recife. Para alcançar os objetivos propostos essa investigação adotou uma perspectiva qualitativa. A metodologia consistiu no acompanhamento de formações continuadas ofertadas, aos professores de 4ºs e 5ºs anos, pela Rede Municipal de Ensino de Recife ao longo de 5 meses de formação. A primeira parte da pesquisa consistiu na análise documental do Plano de Ação/2018 em que havia a programação anual das formações. Em seguida foram analisadas as respostas dadas pelos docentes em um formulário avaliativo e os relatórios feitos pelas formadoras responsáveis por esse grupo de professores. Os resultados evidenciaram que o modelo de organização das formações possibilitaram um aprofundamento de temáticas trabalhadas por semestres, apesar de haver algumas limitações. Nas avaliações, os docentes apontaram que nem sempre as formações auxiliava-os em sua prática, já que os temas propostos no primeiro semestre só seriam trabalhados pelos docentes no segundo semestre, segundo a matriz curricular da referida rede. Os momentos formativos, de uma forma geral, foram bem avaliados pelos/as professores, que percebiam, em grande parte, a articulação entre teoria e prática, bem como reconheciam o espaço, durante a formação, para o compartilhar de experiências docentes. Conclui-se, então, que o momento de formação continuada é importante para o fortalecimento da identidade docente, promovendo uma ressignificação da ação pedagógica e o aumento do protagonismo dos professores.
Assessment of hand hygiene practice among residents of Uyo-southern Nigeria during the COVID-19 pandemic
Authors: Ubani Blessing Chinenye , Ekuma Agantem Emmanuel , Akpabio Akpabio Akanimo , Akpabio Tiemah Ntiense
Published: November 2020

The COVID19 pandemic has caused widespread global devastation with over 11 million infections and 534,000 deaths recorded at the end of June 2020. Measures such as physical distancing and regular hand hygiene are effective in controlling the disease, though compliance varies. This study aimed to determine the frequency of hand hygiene compliance, identify reasons for non-compliance as well as significant associations of hand hygiene performance, type and duration. Visitors to two landmark sites in Uyo—southern Nigeria, (a tertiary hospital and a popular mall) were observed for hand hygiene compliance. The type and duration of hand hygiene was also assessed. A subset of the participants was subsequently invited to participate in an interviewer-administered survey comprising questions on hand hygiene frequency, type, duration and reasons for non-compliance. Ethical approval was obtained for the study. A total of 490 subjects were observed from both sites (280 from the mall and 210 from the hospital), while 155, comprising 52.9% females and 47.1% males, with a mean age of 32.3 ± 11.2 years completed the survey. Although almost all patients (94.2%) considered hand hygiene a necessity, most (65.2%) forgot to wash their hands. Majority of the participants (74.3%) performed hand hygiene, while using soap and running water was the preferred method in majority (80.6%). Age and location were significantly associated with hand hygiene performance, type and duration

Over 70% of adult residents in Uyo performed hand-hygiene though infrequently. Forgetfulness was the most common reason for non-compliance. Public education and compulsion at public places are key strategies in improving hand hygiene compliance.