bluuebunny/crossref_metadata_2025 huggingface dataset:
Selective Activation of G Protein-coupled Estrogen Receptor 1
Attenuates Atherosclerosis
Authors: Haider Mohammad Zulqurnain , Sahebkar Amirhossein , Eid Ali H.
Published: May 2023

therosclerosis remains a leading contributor to cardiovascular disease-associated
morbidity and mortality. Interestingly, atherosclerosis-associated mortality rate is
higher in men than women. This suggested a protective role for estrogen in the cardiovasculature.
These effects of estrogen were initially thought to be mediated by the classic estrogen
receptors, ER alpha, and beta. However, genetic knockdown of these receptors did
not abolish estrogen’s vasculoprotective effects suggesting that the other membranous Gprotein
coupled estrogen receptor, GPER1, maybe the actual mediator. Indeed, in addition
to its role in vasotone regulation, this GPER1 appears to play important roles in regulating
vascular smooth cell phenotype, a critical player in the onset of atherosclerosis.
Moreover, GPER1-selective agonists appear to reduce LDL levels by promoting the expression
of LDL receptors as well as potentiating LDL re-uptake in liver cells. Further
evidence also show that GPER1 can downregulate Proprotein Convertase Subtilisin/
Kexin type 9, leading to suppression of LDL receptor breakdown. Here, we review
how selective activation of GPER1 might prevent or suppress atherosclerosis, with less
side effects than those of the non-selective estrogen.
Hydrogen Sulfide: Physiological Roles and Therapeutic Implications
against COVID-19
Authors: Abolfazli Sajad , Ebrahimi Nima , Morabi Etekhar , Asgari Yazdi Mohammad Amin , Zengin Gokhan , Sathyapalan Thozhukat , Jamialahmadi Tannaz , Sahebkar Amirhossein
Published: May 2023

The COVID-19 pandemic due to severe acute respiratory syndrome coronavirus
2 (SARS-COV-2) poses a major menace to economic and public health worldwide.
Angiotensin-converting enzyme 2 (ACE2) and transmembrane protease serine 2
(TMPRSS2) are two host proteins that play an essential function in the entry of SARS--
COV-2 into host cells. Hydrogen sulfide (H2S), a new gasotransmitter, has been shown to
protect the lungs from potential damage through its anti-inflammatory, antioxidant, antiviral,
and anti-aging effects. It is well known that H2S is crucial in controlling the inflammatory
reaction and the pro-inflammatory cytokine storm. Therefore, it has been suggested
that some H2S donors may help treat acute lung inflammation. Furthermore, recent research
illuminates a number of mechanisms of action that may explain the antiviral properties
of H2S. Some early clinical findings indicate a negative correlation between endogenous
H2S concentrations and COVID-19 intensity. Therefore, reusing H2S-releasing
drugs could represent a curative option for COVID-19 therapy.
Network Pharmacology and Molecular Docking Analysis on Molecular Targets and
Mechanisms of Fei Jin Sheng Formula in the Treatment of Lung Cancer
Authors: Zhang Yun-Chao , Gao Wen-Cang , Chen Wei-Jian , Pang De-Xiang , Mo Da-Yu , Yang Min
Published: May 2023

Background:

Fei Jin Sheng Formula (FJSF) is widely used in clinical treatment of lung cancer. But
the underlying active ingredients and mechanisms are unclear.

Objective:

To investigate the active components and functional mechanisms of FJSF in treating lung cancer
using a network pharmacology approach and molecular docking combined with vitro experiments.

Methods:

Based on the TCMSP and related literature, the chemical components of related herbs in FJSF were
collected. The active components of FJSF were screened by ADME parameters, and the targets were predicted
by the Swiss Target Prediction database. The "drug-active ingredient-target" network was constructed by Cytoscape.
Disease-related targets of lung cancer were acquired from GeneCards, OMIM, and TTD databases. Then
drug-disease intersection target genes were obtained through the Venn tool. GO analysis and KEGG pathway
enrichment analysis were performed via the Metascape database. Cytoscape was used to construct a PPI network
and perform topological analysis. Kaplan-Meier Plotter was used to analyze the relationship between
DVL2 and the prognosis of lung cancer patients. xCell method was used to estimate the relationship between
DVL2 and immune cell infiltration in lung cancer. Molecular docking was performed by AutoDockTools-1.5.6.
The results were verified by experiments in vitro.

Results:

FJSF contained 272 active ingredients and 52 potential targets for lung cancer. GO enrichment analysis is
mainly related to cell migration and movement, lipid metabolism, and protein kinase activity. KEGG pathway enrichment
analysis mainly involves PI3K-Akt, TNF, HIF-1, and other pathways. Molecular docking shows that the
compound Xambioona, quercetin and methyl palmitate in FJSF has a strong binding ability with NTRK1, APC,
and DVL2. Analysis of the data in UCSC to analyze the expression of DVL2 in lung cancer shows that DVL2
was overexpressed in lung adenocarcinoma tissues. Kaplan-Meier analysis shows that the higher DVL2 expression
in lung cancer patients was associated with poorer overall survival and poorer survival in stage I patients. It
was negatively correlated with the infiltration of various immune cells in the lung cancer microenvironment.
Vitro Experiment showed that Methyl Palmitate (MP) can inhibit the proliferation, migration, and invasion of
lung cancer cells, and its mechanism of action may be to downregulate the expression of DVL2.

Conclusion:

FJSF may play a role in inhibiting the occurrence and development of lung cancer by downregulating
the expression of DVL2 in A549 cells through its active ingredient Methyl Palmitate. These results provide
scientific evidence for further investigations into the role of FJSF and Methyl Palmitate in the treatment of
lung cancer.
Kechuanning Gel Plaster Exerts Anti-inflammatory and Immunomodulatory Effects on Ovalbumin-induced Asthma Model Rats via ERK Pathway
Authors: Xie Miaomiao , Liu Tingting , Yin Jie , Liu Jing , Yang Liu , Li Ting , Xia Chen , Fan Yanbo
Published: May 2023

Background:

We aimed to evaluate the therapeutic effects of Kechuanning gel plaster
on ovalbumin (OVA)-induced rat model of asthma.

Methods:

Rats were injected with OVA to induce asthma, and Kechuanning gel plaster was administered
after the OVA challenge. The immune cell counts in the bronchial alveolar lavage fluid
(BALF) were calculated after Kechuanning gel plaster administration. The levels of immune factors
in BALF and serum OVA-specific IgE levels were analyzed. Western blot analysis and immunohistochemistry
were carried out to analyze the following proteins: C-FOS, C-JUN, RAS p21
protein activator 1 (RASA1), matrix metalloproteinase 9 (MMP9), RAF1, p-MEK1, tissue inhibitor
of metalloproteinase-1 (TIMP1), and p-extracellular signal-regulated kinase 1 (ERK1).

Results:

Administration of Kechuanning gel plaster led to decreased immune cell counts, inflammatory
cytokines (interleukin (IL)-1β, IL13, and IL17), and OVA-specific IgE expression. Compared
to the normal group, the C-FOS, C-JUN, RASA1, MMP9, RAF1, MEK1, TIMP1, and p-
ERK1 expressions in the model group were significantly increased, whereas Kechuanning gel plaster
administration decreased C-JUN, MMP9, TIMP1, RAF1, MEK1, p-ERK1, C-FOS, and RASA1
protein levels.

Conclusion:

Kechuanning gel plaster exerted its therapeutic effects on OVA-induced asthma model
rats through the ERK signaling pathway. Kechuanning gel plaster could be considered as a
potential alternative therapeutic agent for the management of asthma.
Antiviral Flavonoids: A Natural Scaffold with Prospects as Phytomedicines
against SARS-CoV2
Authors: Saha Chiranjeet , Naskar Roumi , Chakraborty Sandipan
Published: May 2023

Flavonoids are vital candidates to fight against a wide range of pathogenic microbial infections. Due to their therapeutic potential, many flavonoids from the herbs of traditional medicine systems are now being evaluated as lead compounds to develop potential antimicrobial hits. The emergence of SARS-CoV-2 caused one of the deadliest pandemics that has ever been known to mankind. To date, more than 600 million confirmed cases of SARS-CoV2 infection have been reported worldwide. Situations are worse due to the unavailability of therapeutics to combat the viral disease. Thus, there is an urgent need to develop drugs against SARS-CoV2 and its emerging variants. Here, we have carried out a detailed mechanistic analysis of the antiviral efficacy of flavonoids in terms of their potential targets and structural feature required for exerting their antiviral activity. A catalog of various promising flavonoid compounds has been shown to elicit inhibitory effects against SARS-CoV and MERS-CoV proteases. However, they act in the high-micromolar regime. Thus a proper lead-optimization against the various proteases of SARS-CoV2 can lead to high-affinity SARS-CoV2 protease inhibitors. To enable lead optimization, a quantitative structure-activity relationship (QSAR) analysis has been developed for the flavonoids that have shown antiviral activity against viral proteases of SARS-CoV and MERS-CoV. High sequence similarities between coronavirus proteases enable the applicability of the developed QSAR to SARS-CoV2 proteases inhibitor screening. The detailed mechanistic analysis of the antiviral flavonoids and the developed QSAR models is a step forward toward the development of flavonoid-based therapeutics or supplements to fight against COVID-19.
Dual Specificity Phosphatase 3 (DUSP3) Knockdown Alleviates Acute
Myocardial Infarction Damage via Inhibiting Apoptosis and Inflammation
Authors: Yu Kun , Jiang Aixia , Zhao Caixia , Zhang Dongying
Published: May 2023

Background:

Dual Specificity Phosphatase 3 (DUSP3) regulates the innate immune
response and is associated with ischemia/reperfusion (I/R). However, the precise function of
DUSP3 in acute myocardial infarction (AMI) remains to be established.

Methods:

In this study, the AMI model in vivo was established in mice by permanent left anterior
descending coronary artery (LAD) occlusion, and primary neonatal mouse cardiomyocytes were
treated with hypoxia for 12 hours to mimic AMI in vitro. Sh-DUSP3 and AAV9-sh-DUSP3 were
used to knock down the DUSP3 expression. LVEF%, LVFS%, SOD1, and HO-1 level, and TTC
staining were used to test the cardiac function. Flow cytometric analysis, Western blot, and
TUNEL staining were used to investigate the effect of DUSP3 knockdown on apoptosis. Moreover,
we detect inflammatory factors expression and oxidative stress by ELISA. Besides, we investigate
DUSP3 expression by RT-qPCR.

Results:

Our findings determined the role of DUSP3 in the progression of AMI. And demonstrated
that DUSP3 knockdown alleviated oxidative stress, inflammation, and apoptosis. In addition, our
results indicated that DUSP3 knockdown could regulate the expression of p-NF-κB, ICAM1, and
VCAM1.

Conclusion:

Our results demonstrated that the knockdown of DUSP3 could effectively alleviate
AMI symptoms and be mediated through the NF-κB signaling pathway.
Oxidative Biotransformation of Organophosphotioate Pesticides and Acetylcholinesterase Enzymatic Inhibition
Authors: Militani Isabela Aparecida , Mancini Daiana Teixeira , de Castro Alexandre Alves , Ramalho Teodorico Castro
Published: May 2023

Introduction:

Pesticides have lethal properties, capable of controlling or eliminating a living
organism; they block the organisms' vital metabolic processes. They cause serious problems for human
health, as they are highly toxic. The most used pesticides that are considered toxic are known as organophosphothioates
(OP/P=S) in their commercialized form and organophosphates (OP/P=O) in their active
form. These compounds have been the subject of studies on their metabolism and toxicology. According
to research, these pesticides' toxicity is increased when oxidative metabolic desulfurization reactions occur,
with the P=S bond being transformed into a P=O bond. This toxicity is due to the ability of OP/P=O
species to inhibit the human acetylcholinesterase enzyme (HssAChE).

Methods:

To study the oxidative biotransformation of OP/P=S pesticides and the inhibition of the HssAChE
enzyme by OP/P=S and OP/P=O using the molecular docking technique and QM/MM calculations.

Results:

The theoretical results showed that parathion is the compound with the greatest capacity to transform
its P=S bonds into P=O bonds, thus forming the active paraoxon metabolite in the oxidative biotransformation
process. In the HssAChE inhibition by OP/P=S and OP/P=O, our results showed that of all
the compounds investigated, those with the highest inhibitory activities are parathion, paraoxon, malathion,
diazoxon, chlorpyrifos and omethoate.

Conclusion:

This study was essential due to the lack of information in the literature about the oxidative
biotransformation process of OP/P=S pesticides and the ability of these compounds to inhibit HssAChE.
With this study, it was possible to observe that, in the oxidative biotransformation, chlorpyrifos and parathion
have greater capacities to transform into their active metabolites and in the inhibition of the HssAChE
enzyme, it was possible to observe that not all OF/P=O are the ones with the highest abilities to inhibit
the HssAChE enzyme.
Unhealthy Dietary Pattern Associated with Common Mental Disorders in
Adults and Older Adults: A Population-based Study
Authors: de Melo Simplício Ana Paula , de Almeida Fonseca Viola Poliana Cristina , de Carvalho Lavôr Layanne Cristina , de Lima Sousa Paulo Víctor , de Carvalho Carolina Abreu , Lopes Rodrigues Lays Arnaud Rosal , de Sá  Lustosa Larissa Carvalho Ribeiro , da Silva Pinheiro Michelly , de Lima Jaine Magalhães Paz , de Sousa Ibiapina Cyntia Regina Lucio , de  Oliveira Amanda Ferreira Mesquita , de Moura Crisóstomo Jany , Nunes Lopes Denise Maria , de Azevedo Paiva Adriana , da Silva do Nascimento Vanessa , de Macedo Gonçalves  Frota Karoline
Published: May 2023

Background::

Mental and behavioral disorders are influenced by biological, psychological
and social factors, especially income, gender, age and family environment, indicating that
physical health is directly associated with mental health. In this perspective, food consumption is
highlighted as a risk factor for mental health, as healthy behaviors, along with a good quality diet,
can reduce symptoms of anxiety and depression.

Objective::

The objective of this a study is to investigate the association between CMD and dietary
patterns, among other lifestyle and socioeconomic factors.

Method::

Cross-sectional population-based and household study conducted with 1574 individuals
aged over 20 years, of both sexes, residing in Teresina and Picos, Piaui, Brazil. Sociodemographic,
lifestyle and food consumption data were collected. The instrument used to identify
the presence of CMDs was the Self Reporting Questionnaire 20 (SRQ-20). Dietary patterns were
obtained using the Principal Component Analysis method.

Results::

Individuals of female sex, separated, with low education, smokers and lower level of
physical activity had a higher prevalence of common mental disorders. As for the eating pattern,
after adjustments, individuals who adhered to the unhealthy eating pattern had a 9% higher prevalence
of CMD. Furthermore, adherence to the white meat standard represented 12% higher prevalence
of CMD.

Conclusion::

The results showed that, regardless of other socioeconomic and lifestyle factors, adherence
to a more monotonous eating pattern in foods, characterized by the mainly consumption
of animal protein and the lack consumption of foods like fruits and vegetables, as well as a less
healthy one, characterized by the consumption of ultra-processed foods, increases the risk of developing
CMD.
Synthesis of S-2-phenylchromane Derivatives and Evaluation of the Antiproliferative
Properties as Apoptosis Inducers in Cancer Cell Lines
Authors: Zhang Yunfeng , Ma Jiale , Pei Yujie , Xie Zeyuan , Fu Dong-Jun , Li Jun
Published: May 2023

Background:

Cancer remains one of the major health issues globally, where chemotherapy forms the main
treatment mode for different types of cancers. Due to cancer cell ability to develop resistance, decreased clinical effectiveness
of anticancer drugs can occur. Therefore, the need to synthesize novel antitumor drugs remains important.

Objective:

The aim of our work consisted of synthesizing S-2-phenylchromane derivatives containing the tertiary amide
or 1,2,3-triazole fragments with promising anticancer activity.

Methods:

A series of S-2-phenylchromane derivatives were synthesized and evaluated for cytotoxic activity against
three selected cancer cell lines (HGC-27 human gastric carcinoma cell line, Huh-7 epithelial-like tumorigenic cells,
and A549 adenocarcinomic human alveolar basal epithelial cells) using the 3-(4,5-dimethylthiazol-2-yl)-2,5-
diphenyltetrazolium bromide (MTT) assay. Hoechst staining was used to detect the effects of S-2-phenylchromane
derivatives on apoptosis. The apoptosis percentages were detected by annexin V-fluoresceine isothiocyanate/propidium
iodide (Annexin V-FITC/PI) double staining assay with flow cytometry. Expression levels of apoptosis-related proteins
were detected by western blot.

Results:

Cell line A549, consisting of adenocarcinomic human alveolar basal epithelial cells, displayed the highest
sensitivity to the S-2-phenylchromane derivatives. Among these compounds, E2 showed the most potent antiproliferative
activity against A549 cells with an IC50 value of 5.60 μM. Hoechst staining and flow cytometry analysis revealed
apoptosis in A549 cells by compound E2. In addition, activation of the expression levels of caspase-3, caspase-7, and
their substrate poly (ADP-ribose) polymerase (PARP) by E2 was detected by western blot.

Conclusion:

In summary, results point towards compound E2, an S-2-phenylchromane derivative, as a potential lead
molecule in anticancer agents for human adenocarcinomic alveolar basal cells based on the induction of apoptosis.
SARS-CoV-2 Infection and Severity in Patients with Hematologic
Malignancies: A Systematic Review
Authors: SeyedAlinaghi SeyedAhmad , Karimi Amirali , Mirzapour Pegah , Salmani Roghayeh , Razi Armin , Mojdeganlou Hengameh , Mojdeganlou Paniz , Qodrati Mohammad , Jashaninejad Reyhaneh , Paranjkhoo Parinaz , Dadras Omid , Zarezadeh Besharat , Afsahi Amir Masoud , Afzalian Arian , Varshochi Sanaz , Mehraeen Esmaeil , Afsahi Ghazaleh
Published: May 2023

Introduction:

Earlier reports described the possibility of higher SARS-CoV-2 infection and
severity in patients with hematological malignancies. Given the importance and incidence of these
malignancies, we aimed to systematically review SARS-CoV-2 infection and severity in patients with
hematologic cancers.

Methods:

We retrieved the relevant records by searching the keywords in online databases of PubMed,
Web of Science, Cochrane, and Scopus on December 31st, 2021. A two-step screening; title/abstract
and full-text screening, was employed to select the eligible studies. These eligible studies entered the
final qualitative analysis. The study is adhered to the Preferred Reporting Items for Systematic Reviews
and Meta-Analyses (PRISMA) checklist to ensure the reliability and validity of the results.

Results:

Forty studies concerning different hematologic malignancies and the effect of COVID-19
infection on them were included in the final analysis. The findings showed that in general, the prevalence
of SARS-CoV-2 infection and the severity of the disease are often higher in hematologic malignancies
and the patients could experience higher morbidity and mortality compared to general populations.

Conclusion:

It appeared that individuals with hematologic malignancies are more vulnerable to
COVID-19 infection and they experience more severe disease with higher mortality rates. The presence
of other comorbidities could also deteriorate this situation. Further investigation is recommended
to evaluate the outcome of COVID-19 infection in different subtypes of hematologic malignancies.
Construction of Flower-like ZnO Nanoclusters on Functionalized Graphene
Nanosheets for Room Temperature Formaldehyde Sensing
Authors: Hu Huiyun , Guo Lanpeng , Liang Hongping , Lu Ruofei , Lv Sitao , Wang Chenxu , Liu Liming , Yang Haihong , Lee Yi-Kuen , French Paddy J. , Li Hao , Wang Yao , Zhou Guofu
Published: May 2023

Background:

Formaldehyde (HCHO) is one of the sources of indoor air pollution
and a recognized carcinogenic gas, which sets a huge threat to human health. Therefore, it is
urgent to develop a formaldehyde gas sensor with high efficiency, low consumption, and low
limit of detection.

Methods:

With solvothermal and supramolecular assembly methods, we fabricate a nanocomposite
of ZnO/5-aminonaphthalene-1-sulfonic acid (ANS)-reduced graphene oxide (rGO)
through in situ assembling flower-like ZnO nanoclusters on ANS-modified graphene nanosheets
for room temperature formaldehyde detection.

Results:

The flower-like ZnO/ANS-rGO based gas sensor exhibits high response (32%, 5 ppm),
ultra-fast response/recovery times (18/23 s), high selectivity, long-term stability and a low practical
limit of detection (pLOD) of 1 ppm toward HCHO at room temperature, offering significant
advantages and competitiveness in chemiresistive room temperature HCHO sensors.

Conclusion:

The unique flower-like nanostructure of ZnO and the functionalization with ANS
molecules jointly improved the HCHO sensing performance of the composite at room temperature.
This work provides a new approach to designing and preparing high-performance room
temperature gas sensing materials.
Spontaneous four-photon mixing in ghost imaging
Authors: Belinsky A. V.  , Vasilkov V. V.
Published: May 2023

A generalization of the calculation of the formation of ghost images in the course of backward four-photon mixing to the real situation of non-planar spatially limited pumping, which has a Gaussian profile of the fundamental laser mode, is developed, taking into account the specifics of the formation of phantom images. Computer images have been obtained that make it possible to estimate the spatial resolution of the systems. A relatively simple equivalent scheme for describing the process is proposed, which shows that the effect of diffraction in nonlinear systems is similar to its role in ordinary linear optics with a limited aperture. A fiber-optic version of the formation of ghost images is proposed, suitable for the study of hard-to-reach cavities and organs of the human body, which allow the introduction of a thin fiber bundle there. Keywords: quantum entangled states, quantum images, optical systems, ghost images, quantum measurements.
Influence of the chemical composition of the porous matrix and sintering atmosphere on the luminescent properties of bismuth-containing composites
Authors: Girsova M.A.  , Antropova T.V.  , Golovina G.F.  , Anfimova I.A.  , Kurilenko L.N.
Published: May 2023

The spectral-optical and luminescence properties of bismuth-containing composite materials based on matrices of high-silica porous glasses are investigated. Luminescence spectra, luminescence excitation spectra, infrared transmission spectra (8000-4000 cm-1) depending on the composition of different types of matrices and sintering atmosphere (nitrogen, argon) of bismuth-containing composite materials were examined. It was found that the samples of bismuth-containing composite materials are characterized by UV (λem=350 nm), blue-green (λem=410-550 nm) and orange-red (λem=600-725 nm) luminescence due to the presence of various bismuth active centers. The analysis of the spectra obtained by near-infrared spectroscopy demonstrates the formation of Bi2+ dimers of bismuth and bismuth active centers associated with silicon. Keywords: Bismuth-containing composite materials, high-silica porous glass, near-infrared spectroscopy, luminescence, bismuth active centers.
Application of the method of absorption diode laser spectroscopy for measuring the content of -=SUP=-13-=/SUP=-C and -=SUP=-12-=/SUP=-C in exhaled air
Authors: Kireev S. V.  , Kondrashov A. A.  , Shnyrev S. L.
Published: May 2023

The paper reports on experimental studies of the absorption of 13C16O2 in a mixture with 12C16O2 in exhaled air by laser absorption spectroscopy using a diode laser tunable in the frequency range 4860-4880 cm-1. The results of the studies showed that the minimum detectable concentration of 13C16O2 is at a level of less than 20 ppm, and this approach is promising for measuring the content of 13C16O2 in exhaled air for non-invasive online diagnosis of oncological diseases of the gastrointestinal tract at early stages. Keywords: diode laser spectroscopy, carbon dioxide, breath tests, oncological diseases of the gastrointestinal tract.
Thermoreflectometry of single crystals of mercury selenide in the range of 35-300 K in a fiber-optic pump-probe" scheme with a Fabry-Perot interferometer
Authors: Lonchakov A. T.  , Bobin S. B.  , Kotov A. N.  , Starostin A. A.  , Shangin V. V.
Published: May 2023

A study of the reflection of infrared radiation at a wavelength of 1530 nm from the surface of HgSe single crystals in a two-beam pump-probe fiber-optic scheme was carried out using the thermoreflectometry (TR) method with a Fabry-Perot interferometer (FP). Along with the "high-temperature" anomaly of the probe laser signal (at T > 100 K) in the relaxation region, a "low-temperature" anomaly was revealed in the heating region, consisting in a change in signal polarity at T < 50 K. A qualitative interpretation of the observed features of the relative intensity of the reflected signal in the region of heating and relaxation is proposed, based on the hypothesis of two types of energy barriers, separating the bulk chiral states from the Fermi-arc surface states. Keywords: thermal reflection, interferometer, mercury selenide, Weyl nodes.
Forming regimes of Pd/Ge/Au contact system to n-GaAs influence on its electric parameters
Authors: Malevskaya A. V.  , Soldatenkov F. Yu.  , Levin R. V.  , Potapovich N. S.
Published: May 2023

The investigations of Pd/Ge/Au contact system forming regimes influence on the specific contact resistivity to n-type conductivity GaAs layer were carried out. The method of samples surface treatment before the layers evaporation and thermal annealing regimes in H2, N2 and Ar atmosphere influence on contact system parameters was investigated. The specific contact resistivity value (2-3)· 10-6 Ohm· cm2 at the reduced annealing temperature 190oC was archived.. Keywords: Pd/Ge/Au, n-GaAs, surface treatment, thermal annealing
Features of the breakdown in heavy noble gases under the action of Novosibirsk free electron laser radiation
Authors: Sidorov A. V.  , Veselov A. P.  , Vodopyanov A. V.  , Kubarev V. V.  , Gorbachev Ya. I.  , Shevchenko O. A.
Published: May 2023

The results of experimental studies on the breakdown of noble gases (argon and krypton) by terahertz radiation from the Novosibirsk free electron laser (NovoFEL) are presented. For the first time, the breakdown thresholds of noble gases by terahertz radiation were measured in a wide pressure range (0.2-1.5 bar). Previous experiments to measure breakdown thresholds in the THz range in various gases were carried out for hundreds of GHz or at atmospheric pressure. Experimental breakdown thresholds are compared with calculated data using various simplified models. Keywords: THz radiation, gas breakdown, THz laser discharge.
Electron-photon interactions in the conditions of dimensional conductivity restrictions in semiconductor single quantum-size particles in interelectrodic nanogap
Authors: Zhukov N. D.  , Gavrikov M. V.  , Rokakh A. G.
Published: May 2023

For quantum-size particles of the InSb, PbS, HgSe, CdSe semiconductors, a model of competition of dimensional quantum restrictions and blocking with a single-electron current and Coulomb restriction, as well as heating electrons with an electric field of the light wave, is proposed. This made it possible to explain the highly multiplicity (up to two orders of order) of a change in photoconductivity observed in conditions of tunnel conductivity, and in the conditions of the confinement --- the absence of inter-zone and inter-level photoconductivity. The resonant current peaks of quantum conductivity observed on the V-I characteristics when irritating with light of any wavelength (in the interval of 0.4-1.2 μm) are reset or shifted towards smaller voltage values. The energy minimum of quanta recorded in this case is estimated as 100 meV. The results can be useful in resolving issues of application in uncooled IR detectors, including single-photon registration. Keywords: Quantum-size particle, dimensional quantification, one-electron current, single-photon process, inter-zone and intra-zone transitions, tunnel conductivity, Coulomb restriction, quantum conductivity.
Increasing the gain of an antenna array based on Fabry-Perot cavities at high scanning angles
Authors: Litinskaya Ye. A.  , Polenga S. V.  , Salomatov Yu. P.  , Chursina O. A.
Published: May 2023

An approach for increasing the gain of an antenna array based on Fabry-Perot cavities with mechanoelectrical scanning in the 60-90o angle sector by using a radio-absorbing material on the shading subarray is described. Simulation and analysis of the directional characteristics of the antenna array based on Fabry-Perot cavities with a radio-absorbing material have been performed, and the characteristics have been compared with those of the antenna array without an absorber. Conclusions on the applicability of the proposed configuration of the antenna array based on Fabry-Perot cavities in mobile satellite terminals are made. Keywords: antenna array, Fabry-Perot cavity, wide-angle scanning, radio absorber.
EMPIRICAL APPROACH FOR DEVELOPMENT OF PARENTAL PREFERENCES TO ADMIT CHILDREN IN SCHOOLS
Authors: Hussain Mohammed Sajjad , Chand Bharati
Published: May 2023

The present study was taken up to research question of Parental Preference for School Type. When government schools do exist in sufficient numbers alongside private schools, will families choose to enroll children in private schools over government schools? Does curriculum matter? Do other cultural factors matter?
GARLANDING THE SANITATION WORKERS: GLORIFICATION OF LABOR, CASTE AND INDIAN PSYCHE
Authors: Kumar Narender
Published: May 2023

After independence India has made a good progress in many areas such as academia. Indians succeeded to make their presence felt at the best academic institutes in the world and they have been popularly recognized for their contribution. But one thing which could not change even after independence and constitutional provisions is the notion of caste. This is the notion prevalent everywhere and gets reflected in everyday social. This paper makes an attempt to understand two incidents: first, a video, in which some people are garlanding the sanitation workers, got viral on social media in April 2020 during the lockdown; second, the celebrities such as Salman Khan, Shipa Shetty, cricketer Yuvraj Singh and Sonakshi Sinha made comments on a Dalit caste known as Bhangi. The first incident makes an impression that caste is not an issue in the modern India. This paper contests this impression and makes an effort to reveal how caste functions between the sanitation workers and the people who garlanded the sanitation workers. The study also attempts to understand the psyche of the people who made casteist comments.
सामाजिक न्याय के सृजन में साहित्य की भूमिका
Authors: सिंह ब्यूटी
Published: May 2023

.
CRITICAL OBSERVATION OF PSYCHOSOCIAL MEDIATORS OF HEALTH HABITS AND PATTERNS OF HEALTH RELATED BEHAVIOR
Authors: Ranjan Annita
Published: May 2023

Human health in present day’s lifestyle due to technological advancement, stress to compete with world, urbanization, changing lifestyle and changing cultural beliefs of people has given rise to many diseases, particularly life style diseases. The studies have proved that Indians are genetically prone to heart diseases. The top ten causes of illness and death are accidents, suicide and diseases like, cancer, diabetes, blood-pressure and other diseases affected by quality and style of life. These are largely the result of psychological factors, including behavioural pathogens, lack of behavioural immunogens, psychosocial stress and poor coping strategies. The bio-psychosocial model of health and illness refute that biological, social and psychological factors interact in an interdependent or systemic way of maintaining health or causing illness. The emphasis of the article is only on the psychosocial mediators in health and illness. Mediators shape a person's responses to stress. They are the internal and external resources the person can bring to assess and interpret the magnitude stress, to assess his or her own capacities for addressing the stress, and to formulate a coping strategy to overcome the stress.
लघु कथाओं में पर्यावरणीय विमर्ष
Authors: वर्मा सरिता , . तरुणा
Published: May 2023

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INSIGHTS ON GENERATIONS OF DISTANCE EDUCATION WITH REFERENCE TO LEARNING MATERIAL
Authors: Deolankar Uttara
Published: May 2023

Learning is a lifelong and continuous process. It is a process of resultant changes in behaviour and this is brought out with teaching. The learning process has got no boundaries of age and becomes a lifelong process. It cannot be restricted to the four walls of schools or training institutes but can be taught according to the convenience of the learner. The distance education concept comes with an emphasis of planned with opportunities for learning at the student’s convenient time and location. Distance education is two-way communication between the learner and facilitator for providing opportunities to the learner to engage in self–study with the freedom of time, space and pace. Education takes place throughout life in many forms. Today, Distance education is equipped through technological advances. It took many generations for education, which is now imparted through distance mode of education. This research paper highlights the generations of distance education.
FLOOD FURRY AND THE PEOPLE OF INDIA
Authors: Singh Arminder
Published: May 2023

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TRIBAL CHILDREN’S HEALTH AND HYGIENE PRACTICES DURING EARLY CHILDHOOD
Authors: Ramesh Maloth
Published: May 2023

Early Childhood Care and Education (ECCE) is an indispensable foundation for lifelong learning and development, and have critical impact on success at the primary stage of education. It therefore becomes imperative to accord priority attention to ECCE and invest adequately by providing commensurate resources. The present study was conducted in anganwadies centres of Nizamabad and Kamareddy districts of Telangana state. The result reveals that there were significant differences in the health and hygiene practices followed in anganwadies among tribal children during early childhood.
RESEARCH PRODUCTIVITY OF SCIENTISTS: A CASE STUDY OF NATIONAL CENTRE FOR CELL SCIENCE (NCCS), PUNE
Authors: Trimukhe Dhananjay , Wadhwana Alka
Published: May 2023

This paper presents a scientometric analysis of the research output of the scientists. Ten years i.e., 2008 to 2017 research output was drawn from Web of Science online indexing and abstracting databases. Used scientometric tools such as biblioshyni, bibexcel, and VOS viewer software for the study of publication growth, form, and type of publications, a collaboration of researchers with foreign countries, authorship pattern, and productive author.
FOUR FOUNDATIONS OF MINDFULNESS
Authors: . Candavara
Published: May 2023

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THE QUALITIES OF HUMAN BEING
Authors: . Saritta
Published: May 2023

1. The sources of electricity production such as coal, oil, and natural gas have contributed to one-third of global greenhouse gas emissions. It is essential to raise the standard of living by providing cleaner and more reliable electricity . India has an increasing energy demand to fulfill the economic development plans that are being implemented. The provision of increasing quanta of energy is a vital pre-requisite for the economic growth of a country. The National Electricity Plan [NEP] framed by the Ministry of Power (MoP) has developed a 10-year detailed action plan with the objective to provide electricity across the country, and has prepared a further plan to ensure that power is supplied to the citizens efficiently and at a reasonable cost. According to the World Resource Institute Report 2017 , India is responsible for nearly 6.65% of total global carbon emissions, ranked fourth next to China (26.83%), the USA (14.36%), and the EU (9.66%). Climate change might also change the ecological balance in the world. Intended Nationally Determined Contributions (INDCs) have been submitted to the United Nations Framework Convention on Climate Change (UNFCCC) and the Paris Agreement. The latter has hoped to achieve the goal of limiting the rise in global temperature to well below 2 °C . According to a World Energy Council prediction, global electricity demand will peak in 2030. India is one of the largest coal consumers in the world and imports costly fossil fuel . Close to 74% of the energy demand is supplied by coal and oil.
OMPRAKASH VALMIKI'S JOOTHON : A REMARKABLE RECORD OF A RARE INDIAN JOURNEY
Authors: Nagar Anu
Published: May 2023

Omprakash Valmiki, a famous Indian writer, has shown how the so-called "upper caste" in India dominates and suppresses the populace. This study focuses on how the upper caste controls the scheduled caste by many machinery such as tradition, law, religion, culture, and language of the dominant group of people, who are truly in power. In his work Joothan, the author defines a character from the family of minorities, labourers, and peasants. Omprakash, the protagonist, is forced to seed sugarcane on Fauz Sing's land regardless of the fact that his examination is arriving. There are several evidences to support his muteness, which adds to his subaltern status. Dalit writing has made social equality and political involvement a literary theme, completing the unfinished task of economic equality. Man cannot attain total equality without achieving equality on these three concerns. This impeccable equality is fought for in Dalit literature.
मधुकर राव दादा एक समाज सुधारक
Authors: शिंदे जीवन खुशाल राव
Published: May 2023

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COMMERCIAL SEXUAL EXPLOITATION OF CHILDREN: A MENACE
Authors: Tayde Aarti A.
Published: May 2023

What is the Commercial Sexual Exploitation of Children? The Indian Penal Code defines sexual exploitation of children as: forced or unwanted sexual behaviour towards children, Inclusive of outraging the modesty of a child, rape, sodomy etc. Commercial Sexual Exploitation of Children is mostly element of trafficking. Child trafficking can be defined as any person under 18 who is illegally recruited, transported, transferred, harboured or received by threats, force, and coercion or inducing fear for the purpose of exploitation, either within or outside a country. Child trafficking is a common malpractice in India and also in many parts of world. Child exploitation is done for several reasons. Some of the primary reasons are Sexual exploitation. Children, especially girl children are lured into moving to another city and are forced into prostitution, sex tourism and pornography.
EFFECTIVENESS OF LEARNING MANAGEMENT SYSTEM ON ACHIEVEMENT IN ENGLISH AT SECONDARY SCHOOL LEVEL
Authors: Sharma Anju
Published: May 2023

In the present era of globalization, English has emerged as the language of communication both at the national and international level. The present times demand curriculums integrate technology with the teaching learning practices to improve the achievement levels of the students, particularly the language skills. So, the need was felt to design technology integrated instructions for teaching the subject of English which may prove beneficial for the students. The importance of this study lies in its practical value and its contribution to the pedagogical body of knowledge in teaching of English. Using a Learning Management system is an innovative approach to teaching and learning that refers to the mixing of different learning environments. Here it refers to an instructional method designed by combining traditional classroom teaching with asynchronous online learning through learning management system called Moodle. The present study was conducted on the sample of 200 students of secondary schools affiliated to CBSE in Jalandhar City. It aims to study the effectiveness of LMS on the achievement in English of ninth grade students
EFFECTIVE CLASSROOM MANAGEMENT STRATEGIES IN A BLENDED LEARNING ENVIRONMENT
Authors: Majumdar Subrata .
Published: May 2023

This paper is written for the purpose of our growing consciousness about the role of teacher in classroom management in a blended learning environment. Blended learning is relatively a new approach to teaching learning process. It is a practice that combines digital media with traditional teacher led teaching methods. It is now considered as one of the most effective ways to teach and blended learning programs can now be found at all levels of education. However, one of the major concerns for the teachers while implementing blended learning strategies is how to manage the classroom. It is indeed a legitimate concern since all the students aren’t used to flexible learning environment. Teachers in a blended learning system have to follow certain rules for an effective classroom management. This paper aims at pointing out the various factors which affect proper implementation of the blended learning system and the various ways as to how to properly manage a classroom in such a flexible environment so that the teaching learning process is not hampered and students are benefitted.
IMPACT OF DEMONETIZATION AND COVID-19 ON THE USAGE OF INTERNET BANKING OF ICICI AND HDFC BANK IN MARATHWADA REGION
Authors: Newase Shital S. , Warbhuwan Nishikant C.
Published: May 2023

Following demonetization and the COVID-19 pandemic, people have preferred cashless transactions or online transactions over exchanging cash currency. Internet banking encompasses a wide range of banking activities that the consumer can perform online. Because these online transactions can be completed from a distance, contact is not required, and the risk of contracting COVID-19 is reduced. As a result, the purpose of this research is to investigate the use of Internet banking in HDFC and ICICI banks in the Marathwada region before, during, and after the pandemic and demonetization. This is a comparative study to investigate the impact of demonetization & Covid19 on the usage of internet banking offered by respective banks. The study focuses on primary data collected through questionnaires. Secondary data was gathered through online articles on economic times, RBI reports, journals, newspapers, and other sources in order to review the literature and understand the theoretical background of Internet banking in India prior to demonetization, during COVID-19 , and after COVID-19. There is a significant difference in the factors influencing the use of Internet banking services at various stages of a pandemic situation. Banks not only provided internet banking services to customers, but they also increased customer loyalty
प्राथमिक विद्यालयों के छात्र छात्राओं का गणितीय कौशल का अध्ययन
Authors: यादव चन्द्रधारी  .
Published: May 2023

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ग्रामीण भागातील उच्च माध्यमिक विदयालयातील विदयार्थ्यांच्या ऊर्जाबचत अभिवृत्तीचा षोध घेऊन कृतीकार्यक्रमाच्या परिणामकारकतेचा अभ्यास
Authors: पालवे प्रेमकुमार  दिनकर , पोंधे मुकुंद  .
Published: May 2023

मानवी जीवनात ऊर्जेला अनन्य साधारण महत्व आहे.मानव असो की यंत्र ऊर्जेषिवाय कार्य करणे अषक्य आहे.ऊर्जेला इंग्रजीत एनर्जी म्हणतात .एन म्हणजे आत आणि एरऑन म्हणजे कार्य. अर्थात कार्य करण्याची क्षमता म्हणजे ऊर्जा होय. सूर्य हा ऊर्जेचा मुख्य स्त्रोत आहे. सूर्यापासून पृथ्वीला 174 पेटावॅट ऊर्जा मिळते परंतु ती ऊर्जा रूपांतरीत करण्याच्या अभावामुळे देषावर ऊर्जासंकट ओढावले आहे.पारंपारिक ऊर्जास्त्रोत मर्यादित आहेत, लोकसंख्या प्रचंड प्रमाणात वाढत आहे.यामुळे ऊर्जेची मागणी व पुरवठा यात मोठी तफावत आहे. ग्रामीण भागात फक्त 3 ते 6 तास वीज पुरवठा होतो.भारताचा दरडोई ऊर्जा वापर केवळ 540 किलो वॅट आहे.2025 पर्यंत 34000 मेगावॅटचे अतिरिक्त वीज केंद्र उभारण्याची आवष्यकता आहे. त्यासाठी भविश्यात अपारंपारिक ऊर्जास्त्रोतांचा उपयोग केला तर स्वच्छ आणि मुबलक ऊर्जा मिळेल व ऊर्जेची बचत करता येईल.त्याअनुशंगाने प्रस्तुत संषोधन महत्वाचे आहे. सदर संषोधनासाठी मिश्र पध्दतीचा उपयोग केला आहे.सदर संषोधनात न्यादर्ष म्हणून सर्वेक्षणासाठी ग्रामीण भागातील अहमदनगर जिल्हयातील उच्च माध्यमिक विदयालयातील 300 विदयार्थ्याची निवड केली.श्री आनंद विदयालय चिचोंडी षिराळ या विदयालयातील विदयार्थ्यामध्ये ऊर्जा बचत अभिवृत्ती कमी आढळली. म्हणून या विदयालयातील 27 मुले व 27 मुली अषा एकूण 54 विदयार्थ्याची कृतीकार्यक्रमासाठी सहेतूक निवड केली. माहितीचे संख्याषास्त्रीय विष्लेशण टी परिक्षीकेने करून परिकल्पनेचे सत्यापन पडताळले असता ज परिक्षीका मुल्य 0.3442 आले ते मुल्य 0.01 व 0.05 या स्तरावरील टी मुल्यापेक्षा कमी आहे. म्हणून षुन्य परिकल्पनेचा त्याग करावा लागेल व दोन मध्यमानातील फरक लक्षणीय आहे हे दर्षवणारी परिकल्पना स्विकारावी लागेल.ती म्हणजे ग्रामीण भागातील उच्च माध्यमिक विदयालयातील विदयार्थ्यांच्या ऊर्जाबचत अभिवृत्तीचा षोध घेऊन कृतीकार्यक्रम राबविले असता विदयार्थ्याच्या अभिवृत्तीत लक्षणीय फरक दिसून येतो. प्रस्तुत संषोधनात ऊर्जा बचतीसाठी अनेक घटकांचा समावेष व सहभाग आहे म्हणून प्रस्तुत संषोधन उपयुक्त आहे.
TO ACCESS THE REASONS FOR THE FORMATION OF A COALITION GOVERNMENT
Authors: Siddiqui Mohd Aftab , Prabha Kanchan .
Published: May 2023

In order to gain a parliamentary majority and establish a government based on that majority, two or more political parties must agree to collaborate. Though, voting rights are guaranteed in democracies but may not be sufficient to create a majority government. The most significant method to participate in politics is by voting which can be accomplished directly or indirectly, in secret or in the open, by mail or in person. Although Indian politics may not yet be the final choice for dishonest and corrupt individuals, they can no longer be held up as a model of what public service should be. Because decisions in a coalition government are reached by consensus and are based on a shared strategy to gain position. The party's regulations must be adhered to in every detail. The possibility that a powerful opposition was in charge of monitoring policy changes and keeping the public informed about them could not be rejected. So, here, the emergence of coalition form will be discussed and reasons that lead to formation of the same.
AN INVESTIGATION IN TO EFFECT OF CO-OPERATIVE LEARNING ON INDIVIDUAL AND GROUP CO-OPERATIVE WORK
Authors: H Ravi .
Published: May 2023

The present system of education dominantly nurtures a competitive learning environment focusing primarily on the cognitive domain Somewhere Somehow the social nature of learning holds cooperation in high esteem. Helping students develop socially and emotionally is important, if not more important as helping them progress academically keeping this in mind, the effectiveness of cooperative learning was studied in relation to individual and group cooperative work. It revealed that teaching through cooperative learning is able to bring significant changes in the cooperative behaviour of teacher trainees.
A HISTORICAL STUDY OF LIFE AND WORK OF THERAĀNANDA
Authors: . Aggasara , Chawhan Nilima
Published: May 2023

The Venerable Ānanda was one of eighty great disciples of the Buddha, among which he occupied a unique position in the Buddha’s Order. This topic relates to the fact that how he acted himself as a mediator between the Buddha and the monks and the general public as well as the understanding of Ānanda’s life as the personal attendant of the Buddha and his lifelong carrier as the contributor to the Buddha Sāsana. The objective of this paper is the Social, Philosophical, and Historical approach, which will help us to focus on his life and also on what was the social situation, problems, and norms were during the lifetime of the Buddha. One feels that an analytical type of understanding of the subject is required for such an approach.