bluuebunny/crossref_metadata_2025 huggingface dataset:
Drug-resistant human cytomegalovirus infection in children after allogeneic stem cell transplantation may have different clinical outcomes
Authors: Eckle Tobias , Prix Lothar , Jahn Gerhard , Klingebiel Thomas , Handgretinger Rupert , Selle Barbara , Hamprecht Klaus
Published: October 2019

Three seropositive pediatric recipients of allogeneic stem cell transplantation out of a group of 42 patients receiving T-cell–depleted, unrelated transplants and 37 patients receiving T-cell–depleted, haploidentical transplants were monitored longitudinally for human cytomegalovirus (HCMV) infection and the emergence of antiviral drug resistance. Early in the posttransplant course, all 3 patients developed HCMV mutations conferring drug resistance to ganciclovir. One child additionally developed multidrug resistance to foscarnet and cidofovir, with mutations in the viral phosphotransferase gene (UL97) and the DNA-polymerase gene (UL54) being found. These data show that resistant HCMV infection does not necessarily correlate with a severe clinical outcome. The early detection of genotypic resistance up to 129 days before the emergence of phenotypic resistance and the dissociation of resistance patterns among different body sites emphasize the importance of genotypic analyses of different DNA specimens for an efficient antiviral therapy. T-cell–depleted children having transplantation might be at an increased risk for the development of drug resistance.
Infliximab for pediatric patients with ulcerative colitis: a phase 3, open-label, uncontrolled, multicenter trial in Japan
Authors: Tajiri Hitoshi , Arai Katsuhiro , Kagimoto Seiichi , Kunisaki Reiko , Hida Nobuyuki , Sato Noriko , Yamada Hiroshi , Nagano Mieko , Susuta Yutaka , Ozaki Kunihiko , Kondo Kazuoki , Hibi Toshifumi
Published: October 2019

Background

Pediatric ulcerative colitis (UC) is typically more extensive and has a more active disease course than adult UC, and requires early treatment augmentation to achieve and maintain disease remission. The present study aimed to investigate the efficacy, safety, and pharmacokinetic profile of infliximab (IFX) in pediatric patients with moderate-to-severe UC and inadequate response to existing treatment.

Methods

This open-label, uncontrolled, multicenter, Phase 3 trial was conducted at 17 centers in Japan between April 2012 and September 2014. Pediatric patients (aged 6–17 years) diagnosed with moderate-to-severe UC received a treatment protocol comprising 5 mg/kg IFX at Weeks 0, 2, and 6, and Clinical Activity Index (CAI)-based responders at Week 8 also received treatment at 8-week intervals at Weeks 14 and 22, with a final evaluation at Week 30.

Results

A total of 21 patients were treated in this study. IFX therapy rapidly improved clinical symptoms, and this effect was maintained for up to 30 weeks. Overall CAI-based remission rate was 42.9% and overall Pediatric Ulcerative Colitis Activity Index (PUCAI)-based remission rate was 19.0%. Median partial Mayo score was 6.0 at baseline and 4.0 at Week 30 (overall). Among the eight patients who underwent sigmoidoscopy, Mayo response was achieved at Week 30 (overall) in three patients (37.5%). Trough serum IFX concentrations in Week 8 CAI-based responders were maintained throughout the study period. Adverse events and serious adverse events were observed in 95.2 and 14.3% of patients, respectively.

Conclusions

These results support the use of IFX in the treatment of pediatric patients with UC with inadequate response to existing treatment.

Trial registration

ClinicalTrials.gov, registration number: NCT01585155.
What are the information needs of parents caring for a child with Glutaric aciduria type 1?
Authors: Piercy Hilary , Yeo Mildrid , Yap Sufin , Hart Anthony R.
Published: October 2019

Background

Newborn screening has enabled the early diagnosis of Glutaric aciduria type 1, with the possibility of improving neurological outcomes in affected children. Achieving those outcomes requires parents to effectively manage their child’s condition by adherence to a strict dietary regime and responding to situations that may trigger decompensation. The specific information and support needs of this group of parents are unknown.

Methods

A focus group with five parents was conducted to gain insights into the information that parents needed and the ways in which they accessed and used information to manage their child’s condition. A topic guide was used to direct the discussion which was recorded and fully transcribed. All participants gave informed consent. Data were analysed using thematic analysis, a structured approach that contributes to transparency and validity of results while allowing the integration of predetermined and emerging themes. To ensure rigour, two researchers were involved in initial coding of data and key analytic decisions.

Results

Two main themes were identified. ‘Understanding the condition’ explored parent’s needs to understand the scientific complexity of the condition and to be aware of the worst case scenario associated with loss of metabolic control. ‘Managing the condition’ explained how parents co-ordinated and controlled the involvement of other carers and parents’ need to be active partners in medical management to feel in control of the situation.

Conclusions

The study highlights the importance of addressing parents’ initial and ongoing informational needs so they can fulfil their role and protect their child from metabolic harm.
Is there any benefit to adding students to the European council on chiropractic education evaluation teams and general council? An audit of stakeholders
Authors: Peterson Cynthia , Miller Joyce , Humphreys B. Kim , Vall Ken
Published: October 2019

Background

The European Council on Chiropractic Education (ECCE) is currently the only chiropractic specific accrediting body in the world to include students as equal members on Council and accreditation evaluation teams. Therefore, the purpose of this study is to evaluate feedback from four ECCE stakeholder groups regarding the effectiveness of chiropractic students on ECCE General Council and evaluation teams.

Methods

This was a mixed-methods audit using questionnaires including closed statements requesting level of agreement and open-ended statements requesting written responses. The proportion of responses falling into the five categorical options for level of agreement was calculated for each questionnaire using descriptive statistics. The analysis of the two statements per questionnaire requiring written responses used a modified ‘thematic analysis’ approach. Three researchers independently identified themes from the written responses. They then met to agree the final themes for each statement.

Results

The response rates for the four questionnaires ranged from 87 to 100%. Feedback regarding ‘Student members on General Council’ was the least positive with 65% neutral or negative regarding ‘students being prepared for meetings’. Feedback from stakeholders regarding use of students on evaluation teams was universally positive, ranging from 82.4–100% Strongly Agreeing or Agreeing with each closed statement.

Themes were identified for each open statement. The unique contribution students make to evaluation teams was most common. General Council feedback identified ‘lack of student preparation’ and ‘the short time period of student membership’ as important themes.

Conclusions

This study demonstrates the unique and positive contributions chiropractic students make to accreditation evaluation teams. The results were less positive concerning students on ECCE General Council due to the lack of specific training for their roles and the short time-frame of their membership. Therefore, the ECCE has created training workshops and expanded the time period for students on Council in order to address these issues.
A Consensus on the Diagnosis and Treatment of Acromegaly Comorbidities: An Update
Authors: Giustina Andrea , Barkan Ariel , Beckers Albert , Biermasz Nienke , Biller Beverly M K , Boguszewski Cesar , Bolanowski Marek , Bonert Vivien , Bronstein Marcello D , Casanueva Felipe F , Clemmons David , Colao Annamaria , Ferone Diego , Fleseriu Maria , Frara Stefano , Gadelha Monica R , Ghigo Ezio , Gurnell Mark , Heaney Anthony P , Ho Ken , Ioachimescu Adriana , Katznelson Laurence , Kelestimur Fahrettin , Kopchick John , Krsek Michal , Lamberts Steven , Losa Marco , Luger Anton , Maffei Pietro , Marazuela Monica , Mazziotti Gherardo , Mercado Moises , Mortini Pietro , Neggers Sebastian , Pereira Alberto M , Petersenn Stephan , Puig-Domingo Manel , Salvatori Roberto , Shimon Ilan , Strasburger Christian , Tsagarakis Stylianos , van der Lely A J , Wass John , Zatelli Maria Chiara , Melmed Shlomo
Published: October 2019

Objective

The aim of the Acromegaly Consensus Group was to revise and update the consensus on diagnosis and treatment of acromegaly comorbidities last published in 2013.

Participants

The Consensus Group, convened by 11 Steering Committee members, consisted of 45 experts in the medical and surgical management of acromegaly. The authors received no corporate funding or remuneration.

Evidence

This evidence-based consensus was developed using the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) system to describe both the strength of recommendations and the quality of evidence following critical discussion of the current literature on the diagnosis and treatment of acromegaly comorbidities.

Consensus Process

Acromegaly Consensus Group participants conducted comprehensive literature searches for English-language papers on selected topics, reviewed brief presentations on each topic, and discussed current practice and recommendations in breakout groups. Consensus recommendations were developed based on all presentations and discussions. Members of the Scientific Committee graded the quality of the supporting evidence and the consensus recommendations using the GRADE system.

Conclusions

Evidence-based approach consensus recommendations address important clinical issues regarding multidisciplinary management of acromegaly-related cardiovascular, endocrine, metabolic, and oncologic comorbidities, sleep apnea, and bone and joint disorders and their sequelae, as well as their effects on quality of life and mortality.
Drug Breakdown: Atorvastatin
Authors: Rees Sharon
Published: October 2019

In this column, Sharon Rees aims to refresh knowledge and interest in some of the commonly used drugs in a series of tweets. This month she is talking about #atorvastatin
Leading a nurse-led stoma partnership programme
Authors: Hart Tracey Anne , Benn Allison
Published: October 2019

This article discusses the service re-design within West Essex for the provision of ostomy care. This clinical focus will discuss the history of the service, why and how the service had to be re-designed to improve costs together with patient outcomes. Enabling the specialist nurse to manage a specialist service working in collaboration with the Clinical Commissioning Group can improve prescription costs together with patient outcomes.
A project to introduce peer-tutoring in year 9
Authors: Russell David
Published: October 2019

Raising the aspirations and attainment of disadvantaged students through peer-tutoring has proven successful at Parkside School. David Russell explains how…
Ready for the chalkface?
Authors: Howells Sophie
Published: October 2019

For trainee teachers across the country, September and the start of the NQT year is on the horizon. Sophie Howells seeks some advice from this year's NQT cohort to help you prepare. She also urges this year's NQTs to ensure they get some proper rest this summer
Behaviour management for new teachers
Authors: Bromley Matt
Published: October 2019

Behaviour management is one of the biggest challenges for new teachers. Matt Bromley looks at some tenets of good practice and offers seven strategies for success
Flexible and part-time working in practice
Authors: Sharp Caroline
Published: October 2019

Rising pupil numbers mean that England's schools need more teachers each year, especially in secondary schools where pupil numbers are forecast to rise by 15 per cent over the next decade. Caroline Sharp looks at how increasing part-time and flexible working opportunities could help keep teachers in the profession – and in your school…
Keeping your early career teachers
Authors: Walker Matt , Straw Suzanne
Published: October 2019

Amid the challenges of teacher recruitment, the retention of early career teachers has become even more crucial for schools. Matt Walker and Suzanne Straw consider how the teaching profession can effectively support and retain early career teachers
Curriculum development: Two key questions
Authors: Rollett Stephen
Published: October 2019

Teachers talk a lot about pedagogy, but often neglect to discuss the curriculum and how it translates into their lessons. Curriculum specialist Stephen Rollett looks at how we can have high-quality conversations about what we teach…
Some early career TLC
Authors: Purdy Roger
Published: October 2019

Drawing on research findings can help schools to nurture and support teachers who are in the early stages of their careers. Roger Purdy explains his school's approach
Reducing teacher workload: Part 1
Authors: Bromley Matt
Published: October 2019

Excessive and inappropriate workload is a key reason for teachers quitting the profession. In a two-part SecEd Best Practice Focus, Matt Bromley looks at how schools can keep workload in check. In part one, he touches upon the role of leadership, culture, student behaviour, school routines, email and more. He also offers tips to help teachers protect their own wellbeing
Data: Embracing ‘managed ambiguity’
Authors: Read Chris
Published: October 2019

Schools should rethink their approaches to monitoring and evaluation and move away from meaningless and highly processed data in order to ease the work and accountability load. Chris Read looks at principles of how data should be used…
Continuity in change: A history of radio for national development
Authors: Tietaah Gilbert K. M. , Amoakohene Margaret I. , Smith Marquita S.
Published: October 2019

In this article, we assert and demonstrate a particular and enduring adaptability of radio in tandem with observable temporal shifts in development communication theory and practice in Africa. Specifically, we use the historical research method to explore and explain the ideological discourses, polity contours and social forces that have overlain the role of radio as both an index and an instrument of development in Ghana. The evidence reveals that radio has transitioned through three key milestones in how the technology has been appropriated and applied to national development efforts: from transplantation, through transmission, to transaction. Each of these phases coincides, incidentally, with paradigm shifts in development communication theorizing: from modernization through diffusion to participation. They also coincide, broadly, with three distinctive epochs of ideological shifts in the historical accounting on radio for development in Ghana: from British imperial hegemony, through post-independence command-and-control, to contemporary liberal pluralism.
Chorionic gonadotropin test in the diagnosis of hermaphroditism variants caused by congenital disorders of testosterone biosynthesis
Authors: Samsonova L. N.
Published: October 2019

The study is devoted to search for the optimal modification of chorionic gonadotropin test which permits timely assessment of the function of gonads and, hence, diagnose the variants of hermaphroditism caused by disordered biosynthesis of testosterone. Two modifications of the test: three-day and two-week with measurements of basal and stimulated testosterone levels in the serum were used in 18 patients aged 10 months to 10 years. Both modifications were diagnostically valuable in assessing the function of the gonads in patients with male pseudohermaphroditism. However, the three-day test with its 83% sensitivity may be used only as a screening method in the diagnosis of the above condition.
The general position problem and strong resolving graphs
Authors: Klavžar Sandi , Yero Ismael G.
Published: October 2019

The general position number gp(G) of a connected graph G is the cardinality of a largest set S of vertices such that no three pairwise distinct vertices from S lie on a common geodesic. It is proved that gp(G) ≥ ω(GSR), where GSR is the strong resolving graph of G, and ω(GSR) is its clique number. That the bound is sharp is demonstrated with numerous constructions including for instance direct products of complete graphs and different families of strong products, of generalized lexicographic products, and of rooted product graphs. For the strong product it is proved that gp(G ⊠ H) ≥ gp(G)gp(H), and asked whether the equality holds for arbitrary connected graphs G and H. It is proved that the answer is in particular positive for strong products with a complete factor, for strong products of complete bipartite graphs, and for certain strong cylinders.
Continuous linear operators on Orlicz-Bochner spaces
Authors: Nowak Marian
Published: October 2019

Let (Ω, Σ, μ) be a complete σ-finite measure space, φ a Young function and X and Y be Banach spaces. Let Lφ(X) denote the corresponding Orlicz-Bochner space and
$\begin{array}{}
\displaystyle
\mathcal T^\wedge_\varphi
\end{array}$ denote the finest Lebesgue topology on Lφ(X). We examine different classes of (
$\begin{array}{}
\displaystyle
\mathcal T^\wedge_\varphi
\end{array}$, ∥ ⋅ ∥Y)-continuous linear operators T : Lφ(X) → Y: weakly compact operators, order-weakly compact operators, weakly completely continuous operators, completely continuous operators and compact operators. The relationships among these classes of operators are established.
Exclusion sets in the S-type eigenvalue localization sets for tensors
Authors: Zhang Yuan , Zhang Ying , Wang Gang
Published: October 2019

In this paper, we break the index set N into disjoint subsets S and its complement, and propose two S-type exclusion sets that all the eigenvalues do not belong to them. Furthermore, we establish new S-type eigenvalue inclusion sets, which can reduce computations and obtain more accurate numerical results. At the same time, we give two criteria for identifying nonsingular tensors. Finally, new S-type eigenvalue inclusion sets are shown to be sharper than existing results via two examples.
Ejecting protestors, interpellating supporters: The interactional pragmatics of expulsion at Trump’s campaign rallies
Authors: Sidnell Jack
Published: October 2019

During his campaign for president in 2016, Donald Trump repeatedly instructed his supporters and event security to remove protesters from his rallies, most often, by issuing a directive to “get them out”. These occasions, far from being a distraction from the political process, emerged as potent rituals of participation and the activity of removing protestors became a tool of interactional messaging. Specifically, activities of ejecting protestors were semiotically and discursively elaborated so as to cast them as the virtual realizations of a larger political project of “making America great again.” Various aspects of this include the way these events came to signify about Trump’s persona and the brand of leadership he promised, about immigration reform and border control, about the possibilities for political participation and about a more diffuse struggle against the supposed tyranny of political correctness. Moreover, supporters who responded to the the instruction by attempting to remove protestors were interpellated by it as agents in the local scene of action and were thereby written into the larger populist narrative that Trump articulated.
Genossenschaftsbanken mobilisieren regionale Ressourcen
Authors: Blome-Drees Johannes , Schmale Ingrid
Published: October 2019

Im Rahmen endogener Entwicklungsstrategien sind Genossenschaften wichtige Akteure in regionalen Netzwerken, in denen sie als Promotoren zur Mobilisierung lokaler und regionaler Ressourcen beitragen. Die vorliegende Abhandlung beschreibt und analysiert, welche Leistungen die VR-Bank Nordeifel eG als Genossenschaftsbank zum Erhalt und zur Verbesserung der Lebensgrundlagen und der Lebensqualität in der strukturschwachen Region Nordeifel erbringt. Im Zentrum der Ausführungen stehen ihre Aktivitäten bei der Gründung der Dienstleistungsgenossenschaft Eifel DLG eG.
Shock hipovolémico por ruptura aórtica en perro: un caso de espirocercosis
Authors: Oviedo Socarrás Teresa De Jesús , De Lavalle G. Rodrigo
Published: October 2019

Se presenta un caso de espirocercosis canina, que durante el proceso de migración de la larva culminó en ruptura de la pared de la aorta, con consecuente shock hipovolémico y muerte de un canino de raza Pointer de dos años.
Tratamiento combinado de quimioterapia y cirugía en el tumor venéreo transmisible en caninos
Authors: Sastre Torres José Luis , Mato Lorenzo Yunaika , Lazo Pérez Leonel , Bulnes Goicochea Carlos Anibal
Published: October 2019

Se realizó un estudio descriptivo con el objetivo de evaluar la efectividad de la combinación del tratamiento quirúrgico y quimioterapéutico en el tumor venéreo transmisible (TVT) en caninos. El estudio se realizó con casos llevados a consulta en la clínica veterinaria del municipio de Rodas, Provincia Cienfuegos, Cuba. La población estudiada fue de 57 perros diagnosticados con TVT. Un grupo (n=14) recibió quimioterapia con sulfato de vincristina (0.01 mg/kg, vía endovenosa, tres veces con intervalos de 10 días), un segundo grupo (n=17) fue sometido a tratamiento quirúrgico y el resto (n=26) recibió tratamiento quirúrgico inicial seguido de la quimioterapia, con la misma dosis y concentración que el primer grupo. Los resultados demuestran que la combinación de la cirugía y quimioterapia resultó en la total recuperación de los animales en el 95% de los casos en un periodo de tres meses.
Estudio clínico-patológico del Sarcoide Fibroblastico Equino: reporte de caso clínico
Authors: Pinilla León Juan Carlos , Florez Angel Alberto
Published: October 2019

Se describe el caso en un equino Paso Fino de Colombia de 6 años que presenta una masa recidivante de aspecto irregular, granulomatosa, ulcerativa y hemorrágica en la región del prepucio y pene. Se practicó resolución quirúrgica del tumor, estudio histopatológico y tratamiento posoperatorio del equino. Las características macroscópicas y descripción histológica de las lesiones estudiadas ponen en evidencia la presencia de un Sarcoide de tipo fibroblástico.
Estudio histoquímico e inmunotipificación de poblaciones leucocitarias del timo de alpacas (Vicugna pacos) menores a 60 días de edad
Authors: Grandez R. Ricardo , Mamani P. Javier , Pitot A. Christian , Andrade E. Roy
Published: October 2019

El objetivo del estudio fue identificar las poblaciones leucocitarias en el timo posnatal de alpacas menores de 60 días de edad. Se realizó la eutanasia a seis alpacas Huacaya en la provincia de Huanta, Ayacucho, Perú. Se obtuvieron muestras de timo que fueron embebidas en OTC y congeladas inmediatamente en nitrógeno líquido y conservadas a -70 ºC hasta su procesamiento. Se prepararon secciones congeladas y se fijaron a la lámina con el adhesivo organosilano. Se realizó la inmunohistoquímica con anticuerpo primario de ratón y secundarios de conejo. La reacción se evidenció empleando el complejo avidina-biotina-peroxidasa y se contra-coloreó con Hematoxilina. Se emplearon anticuerpos monoclonales específicos para la identificación de las subpoblaciones leucocíticas del timo; se evaluaron cinco campos visuales de forma aleatoria a un aumento de 400X. La distribución y densidad de la tinción se clasificó como negativa (-), inconstante (±), ligera (+), moderada (++) y fuerte (+++). Los resultados muestran que la mayor población de células leucocitarias se ubicó en la corteza del timo y correspondieron a células inmaduras que no expresan marcadores de superficie; así mismo, la mayor población de células inmunomarcadas, en maduración, se ubicaron en la médula del timo, predominando los linfocitos TCR αβ, con valores bajos de linfocitos TCR γδ, linfocitos CD8, linfocitos B y monocitos/macrófagos, con valores inconstantes de linfocitos CD4. En la corteza del timo se observaron valores bajos de linfocitos TCR αβ y linfocitos CD8, y valores inconstantes de monocitos/macrófagos, sin evidencias de linfocitos TCR γδ, linfocitos CD4 y linfocitos B.
Hallazgos oculares como factores predictivos y diagnósticos de erlichiosis canina
Authors: Trujillo Piso Dunia Yisela , Quijano Ramírez Juan Sebastián , Padilla Barreto Mónica Yamile , Sánchez Bonilla María Del Pilar
Published: October 2019

El objetivo del presente estudio fue determinar la posibilidad de predecir infecciones por Ehrlichia canis con base a lesiones oculares de caninos sin signos clínicos sistémicos aparentes sugerentes de infección por Erlichia. Se trabajó con 30 caninos llevados a la Clínica Veterinaria de la Universidad Cooperativa de Colombia (Ibagué) por alteraciones oculares. Se realizó el examen oftálmico completo. Aquellos con uveítis o hemorragias retinianas se les realizó el SNAP test para Ehrlichia canis. El principal motivo de consulta oftálmico de los pacientes positivos a E. canis fue secreción ocular (33.3%), seguido ojo rojo (30%) y de pérdida de la visión (20%). Al examen oftálmico, la alteración ocular más frecuentemente fue disminución de la presión intraocular (PIO) (93.3%) e hiperemia conjuntival (63.3%). El 46.7% presentó aumento de la secreción ocular y el 40% fue positivo a queratoconjuntivitis seca (KCS) (Rosa de Bengala +). Desprendimiento de retina y edema perivascular de vasos retinianos fue encontrado en el 26.7% de los pacientes. En conclusión, el ojo rojo, PIO baja y la KCS de tipo cualitativo se presentan como hallazgos tempranos de la ehrlichiosis canina; por tanto, estos signos deberían ser considerados como sugerentes de la enfermedad en regiones endémicas.
Fasciola hepatica y otras parasitosis gastrointestinales en bovinos de doble propósito del municipio Sabana de Torres, Santander, Colombia
Authors: Pinilla Juan Carlos , Uribe Delgado Nelson , Florez Angel Alberto
Published: October 2019

El propósito de esta investigación fue determinar la prevalencia de Fasciola hepatica y otras parasitosis gastrointestinales en bovinos doble propósito del municipio Sabana de Torres, departamento de Santander, Colombia. Se colectaron 196 muestras fecales y de sangre en 18 fincas de doble propósito. Los animales fueron estratificados en tres grupos etarios: 0-12, 12-24 y >24 meses. Las muestras fecales se procesaron mediante las técnicas coprológicas de McMaster y Dennis, y la presencia de anticuerpos anti-F. hepatica se determinó mediante una prueba de ELISA indirecto. Se identificaron los géneros de los parásitos según tamaño y morfología de sus huevos o de las larvas infectivas. La prevalencia global de parásitos gastrointestinales fue de 36.7%, siendo los valores más altos para Eimeria sp (19.4%) y Paramphistomum sp (9.2%). La prevalencia coprológica y serológica de F. hepatica fue de 4.1 y 6.1%, respectivamente, lo que refleja que el municipio Sabana de Torres es una zona hipoendémica para F. hepatica. Se encontró asociación estadística (p<0.05) entre el parasitismo por Eimeria sp y el grupo etario.
Efecto de dietas con alta concentración de Saccharomyces cerevisiae sobre la proliferación de hemocitos en camarones Cryphiops caementarius machos
Authors: Cabrera P. Elizabeth , Marcelo T. Zanny , Reyes A. Walter , Azañero D. Carlos
Published: October 2019

El objetivo del estudio fue evaluar el efecto de dietas con alta concentración de Saccharomyces cerevisiae sobre la proliferación de hemocitos en camarones Cryphiops caementarius machos. Los camarones (5.3 ± 1.2 cm de longitud total y 7.4 ± 2.9 g de peso total) se colectaron del río Pativilca (Perú). Cada camarón se mantuvo en un recipiente instalado dentro del acuario (seis camarones por acuario). Se empleó una dieta control (3% de levadura) y tres dietas experimentales (6, 9 y 12% de levadura) con dos repeticiones por tratamiento durante 28 días de cultivo. El número total de hemocitos fue mayor (p<0.05) con 6% de levadura (134.75 x 105 cél/ml), así mismo el número de granulocitos (31.44 x 105 cél/ml) y semigranulocitos (102.44 x 105 cél/ml). El número de hialinocitos disminuyó en todos los tratamientos y se mantuvo entre 0.31 y 1.56 x 105 cél/ml. El número de hemocitos atípicos se mantuvieron bajos en todos los tratamientos y sin diferencias con el basal (0.31 x 105 cél/ml). La dieta con 6% de levadura incrementó (p<0.05) el número total de hemocitos y los hemocitos granulocitos y semigranulocitos en los camarones machos C. caementarius. En cambio, las dietas con 9 y 12% de levadura afectaron (p<0.05) la proliferación de hemocitos totales y diferenciales.
The Effects of Personality, Family Functioning and Perceived Social Support on Suicide: Suicide Risk Among Individuals in Turkish Probation System
Authors: Görgülü Tuğba , Işıkhan Vedat
Published: October 2019

Each year, an average of one million people end their lives by suicide. This rate is higher for disadvantaged groups such as the criminal population and substance users.  Psychiatric problems and certain social factors increase suicide risk. Although the criminal involved and substance users have been studied in Turkey, research on suicide risk factors are limited. Therefore, the aim of this study is to examine the effects of personality traits, and psychosocial variables such as family functioning, and perceived social support on suicide risk in individuals directed to Turkish probation services. Participants were 403 males, of which 183 were substance users and 220 were criminals. Results, revealed a significant relationship between being single, low income, criminal behavior at an early age, substance use behavior, multiple drug use, and suicide risk. Additionally, personality traits of neuroticism and psychoticism, as well as family members’ interest in each other were found to be best predictive variables of suicide risk R2= 0.551, F (12, 389) = 39.79, p<.001; Adjusted R2= .537, and the explained variance ratio was 55%. These results indicate that inclusion of social support factors such as family support, in suicide prevention programs may decrease suicide risk.
NON-LANGUAGE FACTORS AND LANGUAGE EVOLUTION
Authors: A. Kuprieva Irina , B. Smirnova Stanislava , S. Pugach Vladimir , V. Belkina Irina , N. Yatsenko Yulia , V. Kazantsev Denis
Published: October 2019

Purpose: This paper is devoted to the description of the functioning and development of the language system seen in correlation with the influence of non-language factors. Methodology: The methodology of the research is based on the systemic approach to the terms and notions interpretation, analysis of different points of view. Result: As a result, as reality tends to change, the language system meets the requirements for the metamorphosis and starts to absorb new information and adapt to the new conditions. In conclusion, simultaneously the language system, represented by gestalts on the conceptual level, is capable of evolution while knowledge accumulation occurs. Applications: This research can be used for the universities, teachers and education students. Novelty/Originality: In this research, the model of the non-language factors and language evolution is presented in a comprehensive and complete manner.
MAINSTREAMING PEACE IN QURANIC TEACHING TEXTBOOKS FOR MUHAMMADIYAH SCHOOLS
Authors: Nurwanto  , Marsudi
Published: October 2019

Purpose: The article reviews whether the contents of some Quranic understandings taught in Muhammadiyah schools endorse peace or not. By taking account of the increasingly violent acts among Indonesian students, making them more seriously engaged in peace provided by schools, ranging from textbooks to classroom practices, is unavoidable.

Methodology: This study is library research intended to uncover peaceful values contained in the Quranic teaching textbooks provided for those studying at Class X, XI and XII or Senior Secondary levels of Muhammadiyah Schools in Yogyakarta. These textbooks had officially been published by the Council of Basic and Middle Education of the Muhammadiyah Provincial Board headquartered in Yogyakarta. These teaching contents are basically unseparated parts of the subject called ISMUBA (Al-Islam, Muhammadiyah Studies and Arabic). By content analysis usage, this article categorizes and elaborates contents relevant to peace issues.

Result: This article especially focuses on the content analysis of the Quranic exegesis textbooks issued in Yogyakarta. The result shows that those textbooks generally provide contents endorsing peace, interpreted from the Quran. However, they seem to have a lack of both content clarity and some relevant sources. Furthermore, the boundaries of the content might also be affected by the learning targets shaped with relatively low-order thinking skills. Therefore, the textbooks remain engaging in providing peace elements even though some limitations are found.

Applications: This research can be used for universities, teachers, and students.

Novelty/Originality: In this research, the model of mainstreaming peace in Quranic teaching textbooks for Muhammadiyah schools is presented in a comprehensive and complete manner.
PECULIAR FEATURES OF TEACHING HISTORY TO ECONOMIST STUDENTS IN RUSSIAN UNIVERSITIES
Authors: M. Dorozhkin Evgenij , R. Moskalenko Maxim , B. Larionova Marina , A. Kazantseva Ekaterina , E. Loginova Natalia
Published: October 2019

The purpose of the article: The article is aimed at studying of key issues of the set of methods and methodology of teaching history to students of the direction "Economics"; identifying of key aspects of the history course, competent understanding whereof is important for development of professional competencies of future economists, is of special attention.Materials and methods: The leading approach to the study of this problem is the analysis of key problem issues of the history course, a competent understanding of which is important for the formation of professional competencies of economists.Results of the research: The article shows that in the history of economics there are a lot of controversial, controversial issues on which quite superficial, subjective judgments and conclusions can occur in the journalistic, and sometimes academic literature. A number of similar questions are considered, the features of their study with students are revealed. The work identifies key aspects of the course of history, a competent understanding of which is important for the formation of professional competencies of future economists. The recommendations of the methodological and methodological plan for their study are proposed to increase the effectiveness of training future economists.

Applications: This research can be used for the universities, teachers, and students.

Novelty/Originality: In this research, the model of peculiar features of teaching history to economist students in Russian universities is presented in a comprehensive and complete manner.
Evaluation of phytochemical contents and antioxidant activity of pomegranate flower
Authors: KÜÇÜKBAY F. Zehra , TEKİN Zehra
Published: October 2019

Pomegranate is one of the most abundant
fruit consumed in Turkey. This study aimed to determine the content of total
phenolic, total flavonoid and antioxidant activity of Punica granatum L.
flower in different extracts. Antioxidant activities of different extracts were
determined 2,2-diphenyl-1-picrylhydrazyl (DPPH•) radical scavenging, reducing
power and metal chelating methods. The result showed that, total phenolic
content for the extracts was ranged from 14.82 to 90.86 mg gallic acid
equivalents(GAE) / g extract. The contents of flavonoids were found to range
from 7.35 to 500.00 mg quercetin equivalents (QUE)/ g extract. All pomegranate
flower extracts displayed remarkable antioxidant activity according to DPPH and
reducing power assays. Especially the methanolic extract of pomegranate flower
possesses significant scavenging activity against DPPH• (85.80 %), as well as
the largest contents of flavonoids
and phenolic compounds. The antioxidant capacity of the methanolic extract was
also greater than those of BHT and α-tocopherol in DPPH and reducing power
assays. The results demonstrated that the antioxidant activity of extracts of Punica
granatum L. flower might be, at least in part, due to the existence of high
content of flavonoids compounds and other phenolics.
Gestantes adolescentes en la perspectiva de tres docentes de educación física escolar
Authors: Cortés Jhon Carlos , Perea Ita Del pilar
Published: October 2019

Esta investigación de tipo cualitativo interpreta el sentir-pensar-actuar de tres maestros de educación física a partir de su conocimiento y decisiones frente a  casos en los cuales algunas de sus estudiantes se encuentran en estado de gestación. Frente a esto, los sentimientos, conocimientos y actuaciones del maestro se despliegan en actividades que se reflejan en las percepciones de sus estudiantes, de tal manera que genera en ellos modos de pensar, comprender y significar los procesos que se realizan en clase. Para el trabajo de campo se realizaron observaciones no participantes en ficha de registro tres veces por semana durante un periodo de cinco meses. Como complemento a este ejercicio se desarrollaron seis entrevistas semi-estructuradas de dos encuentros con cada participante. Los resultados indican que los docentes actúan de acuerdo a los imperativos disciplinares que privilegian el cuidado del cuerpobiofísico por encima de los aspectos socio-culturales, razón por la cual han hecho del desempeño físico y desarrollo motor los ejes gravitacionales de sus propuestas educativas.
Educación emocional para el desarrollo de competencias emocionales en niños y adolescentes
Authors: Pérez Núria , Filella Gemma
Published: October 2019

A partir de la convicción de que la educación debe preparar para la vida, en los últimos años se ha generado un movimiento a favor de promover, difundir y desarrollar la educación emocional como innovación psicopedagógica. Con un enfoque de ciclo vital, esta forma parte del currículo académico en todas sus etapas. En este artículo se aportan orientaciones para su puesta en práctica y elaborar programas en los centros educativos de cualquier nivel. Se hace una propuesta de los objetivos y contenidos curriculares más apropiados para trabajar con personas de 3 a 16 años. También se reflexiona acerca de las competencias a desarrollar, las metodologías o estrategias didácticas apropiadas y acerca de los criterios a tener en cuenta en la elaboración de los programas de educación emocional.
Claroscuros de la inteligencia emocional iluminan la utopía
Authors: Ibarra Luis Rodolfo
Published: October 2019

El objetivo de este trabajo de reflexión es enriquecer la teoría de la inteligencia emocional. Se contribuye a la alfabetización emocional con la distinción de: impulso, afecto, sentimiento, emoción y afectividad. Asimismo, se ilustran las implicaciones de tal distinción en la humanización. La metodología es de tipo complejo. Se presentan antecedentes de la inteligencia emocional: sus límites y potencialidades, tales como los claroscuros de la psicologización de la educación, la psicología cognitiva, los neuromitos y las teorías de la inteligencia emocional y de los sentimientos. El artículo exhorta a humanizar en aras de una utopía: una humanidad altruista.
Pola Pertumbuhan Dimensi Lingkar Tubuh Babi Bali
Authors: Putra I Made Wira Diana , Sampurna I Putu , Nindhia Tjokorda Sari
Published: October 2019

Pola pertumbuhan dimensi lingkar tubuh babi bali dipengaruhi oleh banyak faktor salah satunya adalah umur. Penelitian ini bertujuan untuk mengetahui pada umur berapa masing masing dimensi lingkar tubuh babi bali mencapai titik infleksi dan ukuran dewasa. Babi yang digunakan dalam objek penelitian ini adalah babi bali yang dipelihara secara tradisional di Desa Musi, Kecamatan Gerokgak, Kabupaten Buleleng, umur 0 sampai 26 minggu sebanyak 56 ekor yang terdiri dari babi bali jantan dan betina. Hasil regresi model sigmoid menunjukkan bahwa ukuran babi bali saat lahir memiliki dimensi lingkar yang sama antara babi Bali jantan dan betina. Lingkar leher babi bali jantan dan betina mencapai ukuran dewasa pada umur  21,840 minggu dan 22,893 minggu.
Studi Histopatologi dan Kadar Timbal pada Ginjal Sapi Bali di Tempat Pembuangan Akhir Suwung Denpasar
Authors: Janardani Ni Made Kunti , Berata I Ketut , Kardena I Made
Published: October 2019

Penelitian ini bertujuan untuk mengetahui perubahan histopatologi dan kadar logam berat timbal pada ginjal sapi bali yang dipelihara di Tempat Pembuangan Akhir (TPA) Suwung Denpasar. Penelitian menggunakan 5 ekor sapi yang dipelihara di TPA. Sapi di nekropsi kemudian diambil organ ginjal sebagai sampel dan selanjutnya dibagi menjadi dua bagian, pertama digunakan untuk pemeriksaan logam berat timbal dan bagian kedua untuk pemeriksaan histopatologi. Pemeriksaan kadar logam berat timbal dilakukan dengan metode Atomic Absorption Spectrofotometri (AAS). Untuk pembuatan preparat histopatologi dilakukan dengan teknik embedded block paraffin dan pewarnaan Hematoxilin-Eosin. Hasil Pemeriksaan 5 sampel ginjal sapi bali secara keseluruhan ditemukan adanya cemaran logam berat timbal yang bervariasi yaitu 0,5829 ppm, 1,0504  ppm, 1,0505 ppm, 1,1305 ppm sampai dengan 1,1306 ppm. Sedangkan pada pemeriksaan histopatologi secara keseluruhan ditemukan perubahan berupa infiltrasi sel radang, degenerasi melemak dan nekrosis. Perubahan histopatologi ini kemungkinan disebabkan oleh toksisitas dari logam berat timbal yang terakumulasi di dalam ginjal. Selain itu, faktor-faktor yang tidak dikendalikan kemungkinan juga berpengaruh. Simpulannya adalah ginjal sapi bali yang dipelihara di TPA Suwung terpapar logam berat timbal dengan perubahan histopatologi peradangan, degenerasi melemak dan nekrosis. Perlu penelitian lebih lanjut tentang pengaruh logam berat timbal yang murni tanpa adanya faktor-faktor lain yang mempengaruhi terhadap perubahan histopatologi ginjal.
Pola Pertumbuhan Panjang Bagian-Bagian Kaki Depan dan Kaki Belakang Babi Bali
Authors: Sembiring Ade Vindha Mebrina br , Suatha I Ketut , Sampurna I Putu
Published: October 2019

Penelitian ini bertujuan untuk mengetahui pola pertumbuhan dan ukuran panjang bagian-bagian kaki depan dan kaki belakang saat mencapai titik infleksi dan ukuran dewasa. 56 ekor babi bali (umur 0 sampai 26 minggu) digunakan sebagai sampel dalam penelitian ini. Data dianalisis dengan model analisis regresi sigmoid, dengan menentukan ukuran maksimum panjang bagian-bagian kaki depan dan kaki belakang saat lahir. Hasil penelitian menunjukkan bahwa panjang bagian-bagian kaki depan dan kaki belakang babi bali mengikuti pola sigmoid. Anak babi pada saat lahir memiliki ukuran panjang kaki yang sama, sedangkan untuk ukuran maksimum, panjang bagian-bagian kaki depan dan belakang terdapat perbedaan antara jantan dan betina. Titik infleksi yang paling cepat dicapai oleh panjang kaki belakang bawah babi jantan pada umur 5 minggu, sedangkan ukuran dewasa tercepat dicapai oleh panjang kaki depan atas babi betina pada umur 58 minggu.
Манифест прикладного конструктивизма
Authors: Непейвода Н.Н. , Бельтюков А.П.
Published: October 2019

Манифест конструктивизма, возрожденный. Эта конструктивная концепция в некоторых отношениях более либеральная, а в некоторых более строгая, чем традиционные. Он призван объединить лучшие стороны интуиционизма и советского конструктивизма и применить его к практическим проблемам информатики и других областей.
Логика и процедуры поиска вывода
Authors: Брюшинкин В.Н.
Published: October 2019

В статье рассматриваются возможности теории поиска доказательств для моделирования творчества и решения логико-философских задач. Анализируются идеи выдающегося русского логика Владимира Смирнова. Появление теории поиска доказательств объясняется в свете модели развития научных теорий Бориса Грязнова. Объяснение основано на новой интерпретации неожиданных последствий (поризма) теории доказательств Гильберта, в частности, на основе построения доказательств снизу вверх в секвенциальных логических системах, принципа подформульности и его интерпретации в области процедур автоматического поиска доказательств.
Хорошо определенные логики
Authors: Горбунов И.А.
Published: October 2019

В данной статье рассматриваются некоторые вопросы, касающиеся теоремы дедукции для операторов следования и сентенциальных исчислений.
Логика функционального следования
Authors: Шалак В.И.
Published: October 2019

Целью данной работы является определение понятия функционального следования и его аксиоматизации. Проблема полноты относительно предложенной семантики остается открытой.
An approach to the interpretation on intensional contexts
Authors: Смирнова Е.Д.
Published: October 2019

The paper introduces a non-standard analysis of intensional contexts on the ground of generalized approach to semantics construction. The principles of building such kind semantics are consider. As far as I can see it is an idea on domains and anti-domains that lays in the ground a semantics of intensional contexts. Intensional contexts differ from extensional by ascription of specific values to intensional predicates (operators) and, what is more important, by a way of their combination with arguments. Thus constructing operations play the leading role in proposed analysis. The peculiarities of IPL: any expression including intensional predicates and operators has an intension as well as an extension.
Equality of consequence relations in finite-valued logical matrices
Authors: Девяткин Л.Ю.
Published: October 2019

In this paper the procedure is presented that allows to determine in finite number of steps if consequence relations in two finite-valued logical matrices for propostional language L are equal.
The concept of ‘Translation’: history and theory
Authors: Карпенко И.А.
Published: October 2019

This article deals with the problem of translations. It covers the history of translation in linguistics and analyzes peculiarities and role of translation in logic. Moreover, the article contains typical examples of embedding operations in terms of different logical theories.
The modified Ramsey theorem is not a G_del sentence
Authors: Хинтикка Я. 
Published: October 2019

G_delian sentences are self-referential first-order sentences in the language of arithmetics. Perhaps the most celebrated one is the sentence which asserts its own unprovability. It is well known that this sentence is neither provable nor refutable in PA (Peano Arithmetics). Some logicians and philosophers have complained that such a sentence is difficult to grasp given its ‘meta-theoretical’ content and they started to look for undecidable arithmetical statements which have a combinatorial content. One such sentence is a variant of Ramsey’s sentence: the Paris-Harrington theorem asserts its undecidability. In the present paper I shall argue that such a sentence is not first-order expressible and thereby it does not provide the desired example of a combinatorial, undecidable arithmetical sentence. Instead I shall argue that it is expressible in Independence-friendly (IF) logic.
Natural three-valued logics and classical logic
Authors: Томова Н.Е.
Published: October 2019

In this paper implicative fragments of natural three- valued logic are investigated. It is proved that some fragments are equivalent by set of tautologies to implicative fragment of classical logic. It is also shown that some natural three-valued logics verify all tautologies of classical propositional logic.
The path of logic in Ukraine
Authors: Хоменко И.В.
Published: October 2019

This paper traces the development of history of logic in Ukraine in the 19th century and early 20th century. The author particularly discusses and compares the logical concepts of representatives of Kyiv philosophies, who made their contribution to the development of logic as a science and academic discipline. Some of them had sunk into oblivion for a long time and their names are still unknown in the logic community.