bluuebunny/crossref_metadata_2025 huggingface dataset:
Principles and Challenges in anti-COVID-19 Vaccine Development
Authors: Strizova Zuzana , Smetanova Jitka , Bartunkova Jirina , Milota Tomas
Published: February 2021

The number of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-infected patients keeps rising in most of the European countries despite the pandemic precaution measures. The current antiviral and anti-inflammatory therapeutic approaches are only supportive, have limited efficacy, and the prevention in reducing the transmission of SARS-CoV-2 virus is the best hope for public health. It is presumed that an effective vaccination against SARS-CoV-2 infection could mobilize the innate and adaptive immune responses and provide a protection against severe forms of coronavirus disease 2019 (COVID-19) disease. As the race for the effective and safe vaccine has begun, different strategies were introduced. To date, viral vector-based vaccines, genetic vaccines, attenuated vaccines, and protein-based vaccines are the major vaccine types tested in the clinical trials. Over 80 clinical trials have been initiated; however, only 18 vaccines have reached the clinical phase II/III or III, and 4 vaccine candidates are under consideration or have been approved for the use so far. In addition, the protective effect of the off-target vaccines, such as Bacillus Calmette-Guérin and measles vaccine, is being explored in randomized prospective clinical trials with SARS-CoV-2-infected patients. In this review, we discuss the most promising anti-COVID-19 vaccine clinical trials and different vaccination strategies in order to provide more clarity into the ongoing clinical trials.
An Update on the Epidemiological Features of Imported Schistosomiasis and Cystic Echinococcosis in Kuwait, 2010–2018
Authors: Al-Awadhi Mohammad , Iqbal Jamshaid , Ahmad Suhail
Published: February 2021

Objective: Kuwait is considered a non-endemic country for most parasitic infections. However, ∼70% of 4.7 million residents in Kuwait are expatriates from Asian and African countries, which are endemic for parasitic infections. Results of microbiological investigations for schistosomiasis and cystic echinococcosis (CE) performed in a reference national laboratory were retrospectively collected and analyzed to provide an insight on the epidemiology of these 2 neglected tropical diseases in Kuwait. Subjects and Methods: Schistosoma infection in fecal and urine specimens from suspected patients was detected by microscopy. Schistosoma and CE infections were also detected by indirect hemagglutination assays (IHAs) using blood specimens. Patients’ epidemiological data were extracted from the laboratory records. Results: The overall prevalence rates of schistosomiasis and CE were 19.0 and 5.8%, respectively. Almost all schistosomiasis cases were seen among Egyptians, especially among males, and a significantly higher prevalence (p < 0.05) was seen for CE cases among the Syrian residents. A decreasing annual trend was observed for both the parasitic infections over time in Kuwait. Conclusions: This study confirmed that schistosomiasis is not autochthonous in Kuwait, as all cases were detected among expatriates from Schistosoma-endemic countries. Our data also showed that CE remains endemic among humans and livestock in Kuwait as is also seen in other Middle Eastern countries.
Artificial Intelligence–Enabled Assessment of the Heart Rate Corrected QT Interval Using a Mobile Electrocardiogram Device
Authors: Giudicessi John R. , Schram Matthew , Bos J. Martijn , Galloway Conner D. , Shreibati Jacqueline B. , Johnson Patrick W. , Carter Rickey E. , Disrud Levi W. , Kleiman Robert , Attia Zachi I. , Noseworthy Peter A. , Friedman Paul A. , Albert David E. , Ackerman Michael J.
Published: February 2021

Background:

Heart rate–corrected QT interval (QTc) prolongation, whether secondary to drugs, genetics including congenital long QT syndrome, and/or systemic diseases including SARS-CoV-2–mediated coronavirus disease 2019 (COVID-19), can predispose to ventricular arrhythmias and sudden cardiac death. Currently, QTc assessment and monitoring relies largely on 12-lead electrocardiography. As such, we sought to train and validate an artificial intelligence (AI)–enabled 12-lead ECG algorithm to determine the QTc, and then prospectively test this algorithm on tracings acquired from a mobile ECG (mECG) device in a population enriched for repolarization abnormalities.

Methods:

Using >1.6 million 12-lead ECGs from 538 200 patients, a deep neural network (DNN) was derived (patients for training, n = 250 767; patients for testing, n = 107 920) and validated (n = 179 513 patients) to predict the QTc using cardiologist-overread QTc values as the “gold standard”. The ability of this DNN to detect clinically-relevant QTc prolongation (eg, QTc ≥500 ms) was then tested prospectively on 686 patients with genetic heart disease (50% with long QT syndrome) with QTc values obtained from both a 12-lead ECG and a prototype mECG device equivalent to the commercially-available AliveCor KardiaMobile 6L.

Results:

In the validation sample, strong agreement was observed between human over-read and DNN-predicted QTc values (−1.76±23.14 ms). Similarly, within the prospective, genetic heart disease–enriched dataset, the difference between DNN-predicted QTc values derived from mECG tracings and those annotated from 12-lead ECGs by a QT expert (−0.45±24.73 ms) and a commercial core ECG laboratory [10.52±25.64 ms] was nominal. When applied to mECG tracings, the DNN’s ability to detect a QTc value ≥500 ms yielded an area under the curve, sensitivity, and specificity of 0.97, 80.0%, and 94.4%, respectively.

Conclusions:

Using smartphone-enabled electrodes, an AI DNN can predict accurately the QTc of a standard 12-lead ECG. QTc estimation from an AI-enabled mECG device may provide a cost-effective means of screening for both acquired and congenital long QT syndrome in a variety of clinical settings where standard 12-lead electrocardiography is not accessible or cost-effective.
The Metamorphosis of a Periplaneta Americana
Authors: de Paulis Daniela
Published: February 2021

The author presents her ongoing artistic research and practice at the intersection of neuroscience and radio astronomy that connects two of her current projects: COGITO in Space and The Metamorphosis. The author focuses primarily on theoretical concepts underpinning her projects, encompassing philosophy of mind and animal ethics. The artistic vision and collaborative work in COGITO in Space has been extensively addressed and presented by the author in previous papers that provide complementary reading to this text.
The Observer Effect: The Artistic Image as a Metaphor for Scientific Interpretations of the Natural World
Authors: Gubanova Elena
Published: February 2021

In this article, the author presents some of her artworks in which she created artistic images and interpretations of time, space and light that define human life on Earth. In her multimedia installations of the last 10 years, her interest in the scientific study of the universe has been interwoven with her experience as the daughter of an astronomer. The author and her husband collaborate to express their thoughts on science and philosophy through a combination of art and engineering solutions and technologies.
A new alpine skink species (Scincidae: Eugongylinae: Oligosoma) from Kahurangi National Park, New Zealand
Authors: PATTERSON GEOFF B. , HITCHMOUGH RODNEY A.
Published: February 2021

A new species of Oligosoma is described from a slate scree in montane tussock grassland in Kahurangi National Park, New Zealand, where it is currently known from a single small site. The new species (Oligosoma kahurangi sp. nov.) can be distinguished from all congeners by its extremely long tail, 36–38 mid-body scale rows, head length/head width ratio of 1.66, and colour pattern. It is part of the O. longipes Patterson species complex. The species is currently very poorly known but likely to be highly threatened, and we suggest listing as Nationally Critical (Data Poor, One Location) in New Zealand, and Data Deficient in the IUCN red-list. Predation by introduced mammals, particularly mice, is assumed to be a threat to its survival.
Satellite-Based Regionalization of Solar Irradiation in Vietnam by k-Means Clustering
Authors: Thanh Nga Pham Thi , Ha Pham Thanh , Hang Vu Thanh
Published: February 2021

This study presents the application of k-means clustering to satellite-based solar irradiation in different regions of Vietnam. The solar irradiation products derived from the Himawari-8 satellite, named AMATERASS by the solar radiation consortium under the Japan Science and Technology Agency (JST), are validated with observations recorded at five stations in the period from October 2017 to September 2018 before their use for clustering. High correlations among them enable the use of satellite-based daily global horizontal irradiation for spatial variability analysis and regionalization. With respect to the climate regime in Vietnam, the defined 6-cluster groups demonstrate better agreement with the conventionally classified seven climatic zones rather than the four climatic zones of the Köppen classification. The spatial distribution and seasonal variation in the regionalized solar irradiation reflect interchangeable influences of large-scale atmospheric circulation in terms of the East Asian winter monsoon and the South Asian summer monsoon as well as the effect of local topography. Higher daily averaged solar radiation and its weaker seasonal variation were found in two clusters in the southern region where the South Asian summer monsoon dominates in the rainy season. Pronounced seasonal variability in solar irradiation in four clusters in the northern region is associated with the influence of the East Asian monsoon, resulting in its clear reduction during the winter months.
The Role of Vegetation in Flash Drought Occurrence: A Sensitivity Study Using Community Earth System Model, Version 2
Authors: Chen Liang , Ford Trent W. , Yadav Priyanka
Published: February 2021

Flash droughts are noted by their unusually rapid rate of onset or intensification, which makes it difficult to anticipate and prepare for them, thus resulting in severe impacts. Although the development of flash drought can be associated with certain atmospheric conditions, vegetation also plays a role in propagating flash drought. This study examines the climatology of warm season (March–September) flash drought occurrence in the United States between 1979 and 2014, and quantifies the possible impacts of vegetation on flash drought based on a set of sensitivity experiments using the Community Earth System Model, version 2 (CESM2). With atmospheric nudging, CESM2 well captures historical flash drought. Compared with NASA’s Modern-Era Retrospective Analysis for Research and Applications, version 2 (MERRA-2), and National Climate Assessment–Land Data Assimilation System (NCA-LDAS), CESM2 shows agreement on the high flash drought frequency in the Great Plains and southeastern United States, but overestimates flash drought occurrence in the Midwest. The vegetation sensitivity experiments suggest that vegetation greening can significantly increase the flash drought frequency in the Great Plains and the western United States during the warm seasons through enhanced evapotranspiration. However, flash drought occurrence is not significantly affected by vegetation phenology in the eastern United States and Midwest due to weak land–atmosphere coupling. In response to vegetation greening, the extent of flash drought also increases, but the duration of flash drought is not sensitive to greening. This study highlights the importance of vegetation in flash drought development, and provides insights for improving flash drought monitoring and early warning.
The Naval Research Laboratory’s Coupled Ocean–Atmosphere Mesoscale Prediction System-Tropical Cyclone Ensemble (COAMPS-TC Ensemble)
Authors: Komaromi William A. , Reinecke Patrick A. , Doyle James D. , Moskaitis Jonathan R.
Published: February 2021

The 11-member Coupled Ocean–Atmosphere Mesoscale Prediction System-Tropical Cyclones (COAMPS-TC) ensemble has been developed by the Naval Research Laboratory (NRL) to produce probabilistic forecasts of tropical cyclone (TC) track, intensity and structure. All members run with a storm-following inner grid at convection-permitting 4-km horizontal resolution. The COAMPS-TC ensemble is constructed via a combination of perturbations to initial and boundary conditions, the initial vortex, and model physics to account for a variety of different sources of uncertainty that affect track and intensity forecasts. Unlike global model ensembles, which do a reasonable job capturing track uncertainty but not intensity, mesoscale ensembles such as the COAMPS-TC ensemble are necessary to provide a realistic intensity forecast spectrum. The initial and boundary condition perturbations are responsible for generating the majority of track spread at all lead times, as well as the intensity spread from 36 to 120 h. The vortex and physics perturbations are necessary to produce meaningful spread in the intensity prediction from 0 to 36 h. In a large sample of forecasts from 2014 to 2017, the ensemble-mean track and intensity forecast is superior to the unperturbed control forecast at all lead times, demonstrating a clear advantage to running an ensemble versus a deterministic forecast. The spread–skill relationship of the ensemble is also examined, and is found to be very well calibrated for track, but is underdispersive for intensity. Using a mixture of lateral boundary conditions derived from different global models is found to improve upon the spread–skill score for intensity, but it is hypothesized that additional physics perturbations will be necessary to achieve realistic ensemble spread.
From Benefits and Beneficiaries: The Historical Origins of Old-Age Pensions From a Political Regime Perspective
Authors: Grünewald Aline
Published: February 2021

Global studies on the historical origins of old-age pensions from a political regime perspective are quite rare. Based on the novel PENLEG dataset this article shows that democratic and nondemocratic regimes had different policy priorities when designing old-age pensions for the first time. Whereas democracies had significantly higher legal pension coverage rates than nondemocratic regimes, the reverse pattern can be found for pension replacement rates. The study also shows that temporal effects and colonial legacy mattered. Longstanding democracies introduced much higher legal pension coverage rates than countries that had recently democratized. Additionally, the French colonial legacy spurred high legal pension coverage rates in African autocracies. These findings underline the importance of taking the multidimensionality of welfare programs into account when analyzing political regime differences. Moreover, due attention must be paid to the historical context when theorizing about welfare policies from a political regime perspective.
Mental health impact of the Covid-19 pandemic on parents in high-risk, low income communities
Authors: Alonzo Dana , Popescu Marciana , Zubaroglu Ioannides Pinar
Published: February 2021

Background:

COVID-19 has spread across the globe, resulting in significant changes in virtually every aspect of life. Mitigation efforts, like shelter-in-place orders, have taken a particular toll on parents who have had to navigate disruptions in work and/or school schedules. Research from high-income countries demonstrates increased parental anxiety, stress, depression, and burnout resulting from the pandemic. It is unclear if these outcomes are the same for parents in high-risk communities in low-income countries where pre-pandemic conditions were deleterious. This study addresses this gap and examines the mental health impact of the pandemic on parents in high-risk communities in Guatemala.

Methods:

A total of 330 individuals from 11 districts in Guatemala participated in the study and were assessed for sociodemographic characteristics and mental health impairment. Chi-squares were conducted for bivariate analysis. Multivariate analysis was conducted using binary logistic regression.

Results:

Bivariate analysis revealed differences between groups on burnout, with parents more often reporting feelings of burnout than nonparents ( p < .001). Binary regression demonstrated that non-parents were 70% less likely to endorse feelings of stress as compared to parents (OR = .285; p = .014).

Conclusion:

Our findings underscore the importance of identifying the unique mental health impact of the COVID 19 pandemic on parents in high-risk communities. In high-risk communities, parental stress is a pressing problem that, if unaddressed, has the potential to result in even greater psychological distress and child maltreatment. Training community healthcare providers to assess and address parental stress can lead to increased community capacity and the development of a community-based network to serve as a first line of support for parents and their children.
Real-Time Brand Reputation Tracking Using Social Media
Authors: Rust Roland T. , Rand William , Huang Ming-Hui , Stephen Andrew T. , Brooks Gillian , Chabuk Timur
Published: February 2021

How can we know what stakeholders think and feel about brands in real time and over time? Most brand reputation measures are at the aggregate level (e.g., the Interbrand “Best Global Brands” list) or rely on customer brand perception surveys on a periodical basis (e.g., the Y&R Brand Asset Valuator). To answer this question, brand reputation measures must capture the voice of the stakeholders (not just ratings on brand attributes), reflect important brand events in real time, and connect to a brand’s financial value to the firm. This article develops a new social media–based brand reputation tracker by mining Twitter comments for the world’s top 100 brands using Rust–Zeithaml–Lemon’s value–brand–relationship framework, on a weekly, monthly, and quarterly basis. The article demonstrates that brand reputation can be monitored in real time and longitudinally, managed by leveraging the reciprocal and virtuous relationships between the drivers, and connected to firm financial performance. The resulting measures are housed in an online longitudinal database and may be accessed by brand reputation researchers.
Disembedded or Deeply Embedded? A Multi-Level Network Analysis of Online Labour Platforms
Authors: Tubaro Paola
Published: February 2021

This article extends the economic-sociological concept of embeddedness to encompass not only social networks of, for example, friendship or kinship ties, but also economic networks of ownership and control relationships. Applying these ideas to the case of digital platform labour pinpoints two possible scenarios. When platforms take the role of market intermediaries, economic ties are thin and workers are left to their own devices, in a form of ‘disembeddedness’. When platforms partake in intricate inter-firm outsourcing structures, economic ties envelop workers in a ‘deep embeddedness’ which involves both stronger constraints and higher rewards. With this added dimension, the notion of embeddedness becomes a compelling tool to describe the social structures that frame economic action, including the power imbalances that characterize digital labour in the global economy.
Trauma-Informed Spiritual Care: Lifelines for a Healing Journey
Authors: Hunsinger Deborah van Deusen
Published: February 2021

The article describes how primary, secondary, intergenerational and collective trauma are intertwined in our lived experience, especially in times of severe stress, such as the current coronavirus pandemic. An argument is made for personal and collective mourning, and for developing an attitude of curiosity, openness, acceptance, and love toward oneself and others who suffer traumatic stress. The foundational lifeline of trust in God is nurtured by the faith and practice of the church through the witness of Scripture, worship, prayer, song, and mutual caring.
The smart grid as a security device: Electricity infrastructure and urban governance in Kingston and Rio de Janeiro
Authors: Pilo’ Francesca
Published: February 2021

This article aims to contribute to recent debates on the politics of smart grids by exploring their installation in low-income areas in Kingston (Jamaica) and Rio de Janeiro (Brazil). To date, much of this debate has focused on forms of smart city experiments, mostly in the Global North, while less attention has been given to the implementation of smart grids in cities characterised by high levels of urban insecurity and socio-spatial inequality. This article illustrates how, in both contexts, the installation of smart metering is used as a security device that embeds the promise of protecting infrastructure and revenue and navigating complex relations framed along lines of socio-economic inequalities and urban sovereignty – here linked to configurations of state and non-state (criminal) territorial control and power. By unpacking the political workings of the smart grid within changing urban security contexts, including not only the rationalities that support its use but also the forms of resistance, contestation and socio-technical failure that emerge, the article argues for the importance of examining the conjunction between urban and infrastructural governance, including the reshaping of local power relations and spatial inequalities, through globally circulating devices.
Motivation, Legitimation, or Both? Reciprocal Effects of Parental Meritocratic Beliefs and Children’s Educational Performance in China
Authors: Olivos Francisco
Published: February 2021

Different research traditions have long held that parental beliefs motivate children’s performance. However, regarding meritocratic beliefs, sociologists often argue that meritocratic narratives legitimize and make sense of societal inequalities as justly deserved. Using the case of China, I tested these competing hypotheses of the relationship between parental meritocratic beliefs and children’s educational achievement. Parental beliefs about skills and hard work as predictors of higher grades were used. I analyzed data from the first and second waves of the China Educational Panel Survey. Autoregressive cross-lagged structural models indicated that parental meritocratic beliefs do not affect children’s educational performance but, rather, meritocratic beliefs are affected by academic results, suggesting their justificatory role. This pattern is much sharper in rural China, where traditional Chinese culture is preserved. The implications of meritocratic beliefs for a broader discussion of citizens’ beliefs about social inequalities and stratification are discussed.
Linking Parental Phubbing to Adolescent Self-Depreciation: The Roles of Internal Attribution and Relationship Satisfaction
Authors: Liu Ke , Chen Weiwei , Lei Li
Published: February 2021

Phubbing is suggested to be a new form of social rejection, yet little is known about how people who are being “phubbed” interpret it within different relationships. Based on the social information processing model and the sociometer theory, this cross-sectional study investigated adolescents’ attribution for parental phubbing and its associations with adolescents’ relationship satisfaction and core self-evaluations. With a survey data from 300 Chinese adolescents, ages 12 to 16, a model linking parental phubbing to adolescents’ core self-evaluations was assessed, in which adolescents’ relationship satisfaction was a mediator and adolescents’ internal attribution for parental phubbing was a moderator. Parental phubbing was found to be associated with lower relationship satisfaction among adolescents who tended to internally attribute for it, which was predictive of their lower core self-evaluations.
The Ambivalence of Aryanism: A Genealogical Reading of India-Europe Connection
Authors: Birkvad Ida Roland
Published: February 2021

How do historical ideas of global, supremacist connection exist alongside ideas of civilisational and racial difference? And what enables certain reactionary, political alliances to traverse colonial hierarchies of power? With an onset in contemporary, transnational connections between a Hindu and a Western Right, this article offers a critical genealogical reading of the concept of Aryanism. Understanding it as articulated historically through interactions between British colonialists and upper-caste Hindus in India, this reading focuses on these elites’ intersecting and contradictory ideas of hierarchy, difference, and cross-civilisational connection. Tracing the empirical, theoretical and political implications of these entanglements, the article contributes to on-going discussions on the imperial roots of conceptual formations and knowledge production in postcolonial International Relations.
Rainfall patterns and geomorphological controls driving inundation frequency in tropical wetlands: How does the Pantanal flood?
Authors: Pereira Gabriel , Ramos Raquel de Cássia , Rocha Leonardo Cristian , Brunsell Nathaniel Alan , Merino Eder Renato , Mataveli Guilherme Augusto Verola , Cardozo Francielle da Silva
Published: February 2021

The Pantanal is one of the world’s largest freshwater wetlands. The spatial and temporal variability of flooded areas is a key factor for preserving and managing the flora and fauna of this biodiversity hotspot, and thus, its dynamic is crucial to maintain ecosystem services. However, existing inventories of flooded areas with high spatial resolution are scarce or do not represent a continuous time series considering the entire Pantanal wetland. In this study, flooded areas were derived from Landsat and Resourcesat satellite imagery time series for the years 2000 to 2020 through big data analytical tools. Our results show that permanently flooded areas accounted for 3.40% of the total Pantanal wetland and 8.85% of the study area was flooded during only one year, indicating a complex and dynamic fluvial system. In addition, approximately 39% of the basin was composed of non-flooded areas. During the analyzed period (2000–2020), the highest flood event occurred in 2011 covering an area of 57,969 km2, followed by 2014, with 52,500 km2 (respectively 38.55% and 34.91% of the total area of the Pantanal). The year with the smallest flooded area was 2020 (10,668 km2), 83% lower when compared to the period-based average. The Pantanal is a seasonal wetland, thus, rainfall plays a significant role in the flood pulse, accounting for approximately 60% of the total variability of the flooded areas. The flood dynamics is also affected by the morphology of the modern depositional system of the Pantanal, which is composed by large megafans created by several distributive rivers, and by neotectonics that generates differential movements of blocks creating lower areas that will determine how flood pulse moves spatially and temporally. Therefore, the understanding and analysis of this dynamism becomes an indispensable tool for the public government ordering defining policies for the occupation and the economic zoning of the Pantanal.
Estimation and Mitigation of Epidemic Risk on a Public Transit Route using Automatic Passenger Count Data
Authors: Kumar Pramesh , Khani Alireza , Lind Eric , Levin John
Published: February 2021

This paper studies the potential spread of infectious disease through passenger encounters in a public transit system using automatic passenger count (APC) data. An algorithmic procedure is proposed to evaluate three different measures to quantify these encounters. The first two measures quantify the increased possibility of disease spread from passenger interaction when traveling between different origin–destination pairs. The third measure evaluates an aggregate measure quantifying the relative risk of boarding at a particular stop of the transit route. For calculating these measures, compressed sensing is employed to estimate a sparse passenger flow matrix planted in the underdetermined system of equations obtained from the APC data. Using the APC data of Route 5 in Minneapolis/St. Paul region during the COVID-19 pandemic, it was found that all three measures grow abruptly with the number of passengers on board. The passenger contact network is densely connected, which further increases the potential risk of disease transmission. To reduce the relative risk, it is proposed to restrict the number of passengers on-board and analyze the effect of this using a simulation framework. It was found that a considerable reduction in the relative risk can be achieved when the maximum number of passengers on-board is restricted below 15. To account for the reduced capacity and still maintain reasonable passenger wait times, it would then be necessary to increase the frequency of the route.
Victimization and Food Addiction Symptoms: Direct and Indirect Effects Through Emotion Dysregulation, Impulsivity, and Loss-of-Control Eating
Authors: Jacques-Tiura Angela J. , Lanni Daniel J. , Anderson Lindsay A. , Naar Sylvie
Published: February 2021

Previous research suggests that dating, intimate partner, and sexual violence victimization throughout the life span are predictive of numerous adverse health outcomes including addictive behaviors, psychopathology, and physical health symptoms. Self-medication hypotheses posit that victims may drink heavily, use substances, or rely on food to cope with negative affect and psychological symptoms. We examined a self-medication hypothesis-driven model linking dating and sexual violence victimization with food addiction symptoms through their relationships with emotion regulation, impulsivity, and loss-of-control eating in a sample of 313 single, non-treatment-engaged, college student women aged 18–25 years old enrolled in a minority serving, urban university. Participants completed an online survey with measures of dating and sexual violence victimization since age 14 years, emotion regulation, impulsivity, loss-of-control eating, and food addiction symptoms. Seventy-nine percent of participants reported experiencing some form of intimate partner violence victimization. Using path analyses, we found some support for our model as well as significant, positive, direct pathways from victimization to loss-of-control eating and food addiction symptoms. Clinicians and policy makers should incorporate these findings into practice by honoring the experiences of past victimizations in current health behaviors and by utilizing trauma-informed care practices. To extend this study’s findings, researchers should examine the role of trauma-informed interventions targeting emotional regulation and impulsivity to decrease loss-of-control eating and food addiction symptoms.
Ten-Year Survivorship, Patient-Reported Outcome Measures, and Patient Acceptable Symptom State After Over-the-Top Hamstring Anterior Cruciate Ligament Reconstruction With a Lateral Extra-articular Reconstruction: Analysis of 267 Consecutive Cases
Authors: Grassi Alberto , Macchiarola Luca , Lucidi Gian Andrea , Silvestri Annamaria , Dal Fabbro Giacomo , Marcacci Maurilio , Zaffagnini Stefano
Published: February 2021

Background:

Long-term patient-reported outcome measures (PROMs) and predictors of success or failure after anterior cruciate ligament (ACL) reconstruction are not fully understood, especially when combined with a lateral extra-articular reconstruction.

Purpose:

To assess the long-term PROMs, revision rate, and predictors of success or failure after ACL reconstructions using an over-the-top surgical technique with single-bundle hamstring tendon autografts and a lateral extra-articular reconstruction.

Study Design:

Case series; Level of evidence, 4.

Methods:

The study cohort consisted of 267 consecutive patients (mean age, 30.7 years) who underwent ACL reconstruction with an over-the-top surgical technique with single-bundle hamstring tendon autografts and a lateral extra-articular augmentation between November 2007 and May 2009. The number of subsequent ACL revisions and reoperations were recorded. Subjective clinical status was assessed with PROMs—specifically, the Knee injury and Osteoarthritis Outcome Score (KOOS), Lysholm, Tegner, and visual analog scale for pain—at a minimum follow-up of 10 years.

Results:

Overall, 3% of patients underwent ACL revision, with a 10-year survival rate of 96.3%. High sport activity (hazard ratio, 6.9; P = .285) and concomitant meniscal lesion (hazard ratio, 2.6; P = .0487) were predictors of ACL revision or new meniscectomy. The mean ± SD Lysholm score was 94.1 ± 10.8, while that for the visual analog scale for pain was 0.2 ± 0.9 at rest and 2.1 ± 2.6 during activity. KOOS subscale scores were as follows: 95.7 ± 8.1 for Pain, 92.5 ± 10.5 for Symptoms, 98.4 ± 7.4 for Activities of Daily Living, 90.7 ± 17.2 for Sport, and 91.2 ± 17.1 for Quality of Life; respectively, 88%, 99%, 81%, 89%, and 91% of patients achieved the Patient Acceptable Symptom State. Female sex and chondropathy with Outerbridge grade ≥2 were predictors of worse KOOS subscales. Overall, 82% of patients returned to sport, and 57% were still participating at the 10-year evaluation.

Conclusion:

ACL reconstruction with an over-the-top surgical technique with single-bundle hamstring autografts and a lateral extra-articular reconstruction provided satisfactory results in terms of function, symptoms, sports, and quality of life in 80% to 90% of patients after 10 years. Long-term survivorship was 96%. Sport participation declined from 82% postoperatively to 57% at long-term follow-up. A concomitant medial meniscal lesion was a predictor of higher risk of ACL failure or new meniscal lesion, while advanced chondropathy and female sex were predictors of higher pain, lower function, and poor quality of life scores.
Course and Predictors of Posttraumatic Stress Disorder in the Canadian Armed Forces: A Nationally Representative, 16-Year Follow-up Study: Cours et prédicteurs du trouble de stress post-traumatique dans les Forces armées canadiennes: une étude de suivi de 16 ans nationalement représentative
Authors: Mota Natalie , Bolton Shay-Lee , Enns Murray W. , Afifi Tracie O. , El-Gabalawy Renée , Sommer Jordana L. , Pietrzak Robert H. , Stein Murray B. , Asmundson Gordon J. G. , Sareen Jitender
Published: February 2021

Objective:

This study examined baseline risk and protective predictors and interim correlates of the persistence/recurrence, remission, and onset of posttraumatic stress disorder (PTSD) in a 16-year prospective, nationally representative sample of Canadian Forces members and veterans.

Methods:

The 2018 Canadian Armed Forces Members and Veterans Mental Health Follow-up Survey is a prospective study of 2,941 regular force service members and veterans who participated in the 2002 Canadian Community Health Survey on Mental Health and Wellbeing: Canadian Forces Supplement ( n = 5,155; ages 15 to 64 years; response rate 68%). PTSD diagnoses in 2002 and 2018 were used to create 4 groups: (1) no lifetime, (2) remitted, (3) new onset, and (4) persistent/recurrent PTSD. Multinomial regressions were conducted to identify predictors of PTSD courses.

Results:

Female sex, being a junior noncommissioned member (vs. officer), and land (vs. air) operations in 2002 were associated with all PTSD courses relative to no lifetime PTSD (relative risk ratio [RRR] range: 1.28 to 3.65). After adjusting for sociodemographic variables, baseline predictors of all PTSD courses included lifetime mental disorder, history of mental health care utilization, all trauma type categories (deployment-associated, sexual, “other”), and the number of lifetime traumatic events (RRR range: 1.14 to 8.95). New (“since 2002”) traumas, transitioning to veteran status, and alcohol dependence were mostly associated with the new onset and persistent/recurrent PTSD courses (RRR range: 1.79 to 4.31), while mental health care utilization and greater avoidance coping were associated with all PTSD courses (RRR range: 1.10 to 17.87). Protective factors for several PTSD courses at one or both time points included social support, social network size, and problem-focused coping (RRR range: 0.71 to 0.98).

Conclusions:

This is the first population-based survey to examine the longitudinal course of PTSD in Canadian Forces members. Prevention and intervention programs focused on bolstering social support and active coping strategies as possible protective factors/correlates may help mitigate the development and persistence of PTSD.
Older Adults’ Self-Reported Barriers to Aging in Place
Authors: Brim Brianna , Fromhold Stacy , Blaney Shannon
Published: February 2021

Current literature on aging in place highlights the socioemotional components that act as barriers to remaining in the home, but it often neglects actionable safety features of the home which may also pose a threat. Furthermore, this literature often neglects self-reported barriers to aging in place. Utilizing grounded theory, a retrospective review of home safety assessments completed in Philadelphia analyzed older adult reports to determine what factors older adults view as barriers to their aging in place plans. Overarching categories that were discovered through the data analysis process included barriers related to home mobility and safety, personal health, access to community services, home improvement and maintenance needs, general safety concerns, and bathroom safety. Results indicate that older adults can identify many barriers to aging within their home, but that accessing support and services to overcome these barriers requires additional resources and funding.
Deep Medullary Vein White Matter Injury Global Severity Score Predicts Neurodevelopmental Impairment
Authors: Benninger Kristen L. , Benninger Tara L. , Moore-Clingenpeel Melissa , Ruess Lynne , Rusin Jerome A. , Maitre Nathalie L.
Published: February 2021

Aim:

To examine associations between the deep medullary vein white matter injury global severity scoring system and neurodevelopmental impairment.

Methods:

This is a prospective observational cohort study of infants born at ≥32 weeks, diagnosed with deep medullary vein thrombosis and infarction on neuroimaging in the first month of life. Developmental testing was performed using validated measures for early, preschool, and school-age follow-up.

Results:

Nineteen (37%) patients had major neurodevelopmental impairment. Global severity score was higher among patients with neurodevelopmental impairment (21.6 vs 13.4, P = .04). Overall, 78% of patients with epilepsy had neurodevelopmental impairment. A greater degree of asymmetry with right-sided injury predominance was associated with lower Bayley-III cognitive scores and presence of neurodevelopmental impairment ( P < .01).

Conclusions:

Results suggest a need for targeted clinical surveillance for patients with a high global severity score and/or asymmetric, predominantly right cerebral white matter injury and for those who develop epilepsy.
Factors Associated With Willingness To Report Intimate Partner Violence (IPV) to Police in South Korea
Authors: Kim Chunrye , Ferraresso Riccardo
Published: February 2021

Intimate partner violence (IPV) is a serious social problem in South Korea, but the IPV reporting rate to the police is not high enough. To reduce violence and further victimization, it is important for IPV (potential) victims to report to police. Thus, this study aimed to examine the factors associated with willingness to report IPV to police if they experience it using the 2013 Korean National Domestic Violence Survey data. A representative sample of 5,000 Korean participants, of whom 1,668 were males and 3,332 were females, were recruited using a stratified multistage sampling design. We found that the willingness to report IPV to the police was statistically significant when the participants were young, had strong knowledge of IPV-related laws, had lower levels of acceptance of violence, had lower levels of conservative gender role values, and when the seriousness of violence was higher for both male and female participants. However, having children and having experienced child abuse only affected women’s willingness to report IPV to the police. Based on this study’s findings, we then discussed policy implications to prevent further victimization, focusing on factors that are associated with willingness to report violence to the police.
Relationship-Based Care Work, Austerity and Aged Care
Authors: Baines Donna , Dulhunty Annabel , Charlesworth Sara
Published: February 2021

Home care and aged care in English-speaking countries around the globe have enthusiastically taken up a model of work known as ‘relationship-based care’ (RBC). Part of the popularity of RBC is because it does not challenge austerity, underfunding, and extensive managerialism. Instead it works within and through them to foster caring connections between patients, staff, and families, and is able to do so because workers are willing to self-sacrifice for clients. Drawing on case study data collected using a ‘rapid ethnography’ methodology in two large Australian aged care organisations, this article explores workers’ experience of work and contributes to Bolton’s typology of emotion management in the relationship-based care endeavour. Our typology includes: (1) austerity-linked sacrifice; (2) official discourse; (3) faux control; and (4) compulsory time philanthropy. The article contributes to debates on care work, relationship-based care, emotional labour, and emotion management and working in the context of austerity and managerialism.
Combining multiple biomarkers to linearly maximize the diagnostic accuracy under ordered multi-class setting
Authors: Hua Jia , Tian Lili
Published: February 2021

Either in clinical study or biomedical research, it is a common practice to combine multiple biomarkers to improve the overall diagnostic performance. Despite the fact there exist a large number of statistical methods for biomarker combination under binary classification, research on this topic under multi-class setting is sparse. The overall diagnostic accuracy, i.e. the sum of correct classification rates, directly measures the classification accuracy of the combined biomarkers. Hence the overall accuracy can serve as an important objective function for biomarker combination, especially when the combined biomarkers are used for the purpose of making medical diagnosis. In this paper, we address the problem of combining multiple biomarkers to directly maximize the overall diagnostic accuracy by presenting several grid search methods and derivation-based methods. A comprehensive simulation study was conducted to compare the performances of these methods. An ovarian cancer data set is analyzed in the end.
Social justice in pandemic immunization policy: We’re all in this together
Authors: Torrie Carmen , Yanicki Sharon , Sedgwick Monique , Howard Lisa
Published: February 2021

Policy decisions regarding immunization during a pandemic are informed by the ethical understandings of policy makers. With the possibility that a vaccine might soon be available to mitigate the deadly COVID-19 pandemic, policy makers can consider learnings from past pandemic immunization campaigns. This critical analysis of three policy decisions made in Alberta, Canada, during the 2009 H1N1 influenza pandemic demonstrates the predominance of distributive justice principles and the problems that this created for vulnerable groups. Vulnerable groups identified in Alberta include rural and First Nations populations. We propose a social justice approach as a viable alternative to inform pandemic immunization policy and invite debate.
Incidence and Risk Factors for Flap Coverage After Total Ankle Arthroplasty
Authors: Cunningham Daniel J. , Ryan Sean P. , Hong Cierra , Mithani Suhail K. , Adams Samuel B.
Published: February 2021

Background:

Wound complications following total ankle arthroplasty (TAA) can have a significant impact on patient morbidity, particularly when they require flap coverage. We sought to determine the risk factors associated with the need for flap coverage after TAA and hypothesized that medical and operative risk factors such as diabetes and additional procedures would be associated with the need for flap coverage after TAA.

Methods:

We performed a single-center retrospective review of TAAs from April 2007 to February 2019. Patient demographics and medical comorbidities were collected, in addition to other procedures performed at the time of TAA. Patients were stratified by the need for flap coverage, and unadjusted inferential statistics were performed to evaluate the risk factors associated with subsequent need for flap coverage.

Results:

Among 2065 patients undergoing TAA, 28 (1.4%) patients required flap coverage after the index arthroplasty. Patients requiring flap coverage were older ( P = .045), had higher Charlson comorbidity indices ( P = .017), and had higher rates of diabetes and pulmonary disease ( P = .038). Patients requiring flap coverage also had higher rates of additional procedures ( P = .043, P = .007). The most common flap was a radial forearm free flap, which was performed in 14 (50%) patients. Twenty-one patients (75%) requiring flap coverage had a stable, plantigrade foot at median 1.5-year follow-up.

Conclusion:

Patient and operative risk factors, including advanced age, increased comorbidity burden, diabetes, pulmonary disease, and increased number of simultaneous procedures, were significantly associated with need for subsequent flap coverage. This should be considered as the indications for TAA expand.

Level of Evidence:

Level III, retrospective, prognostic cohort study.
Effect of Gender Differences on Patient-Reported Outcomes and Complications in Total Ankle Replacement
Authors: Fletcher Amanda N. , Mody Kush S. , Adams Samuel B. , DeOrio James K. , Easley Mark E. , Nunley James A.
Published: February 2021

Background:

The purpose of this study was to evaluate gender differences in patient outcomes and complications following total ankle replacement (TAR).

Methods:

Consecutive patients who underwent primary TAR from July 2007 through May 2016 were prospectively followed and retrospectively reviewed. Demographic, operative, patient-reported outcomes (PROs), and complication data were collected and analyzed. PROs included the visual analog scale (VAS), 36-Item Short-Form Health Survey (SF-36), American Orthopaedic Foot & Ankle Society (AOFAS) hindfoot scale, and Short Musculoskeletal Function Assessment (SMFA). A total of 475 patients were evaluated, including 248 males (52.2%) and 227 females (47.8%) with an average of 56.8 months follow-up.

Results:

Women were more likely to have inflammatory arthritis (13.7% vs 2.8%; P < .01) and significantly worse preoperative SF-36 total, SF-36 mental health component, AOFAS total, AOFAS pain, SMFA function, and SMFA bother scores (all P < .05). Both genders demonstrated significant improvement in PROs at 1, 2, and 5 years. The magnitude of improvement was similar between genders for all PROs (all P < .05) with the exception of SF-36 physical function, which was greater in men. Females underwent more nonrevision reoperations (32.2% vs 22.6%; P = .0191), but there was no significant difference in failure rates (male 7.3% vs female 3.5%; P = .07). The reoperation and failure rates at 2 years postoperation were 10.1% and 1.6% for men and 18.5% and 0.9% for women, respectively.

Conclusion:

Women undergoing TAR were more likely to have worse preoperative PROs and higher rates of nonrevision reoperations, which remains true when controlling for their increased incidence of inflammatory arthritis. However, women reported similar improvements in PROs and had similar prosthetic survival rates as men. Increased understanding of these disparities, combined with gender-based interventions, may further advance patient outcomes.

Level of Evidence:

Level III, therapeutic, retrospective comparative series