bluuebunny/crossref_metadata_2025 huggingface dataset:
OVERVIEW OF THE MAIN SOURCES OF STUDYING PROBLEMS OF ACCOUNTING AND ECONOMIC ANALYSIS OF EVACUATION PROCESSES OF INDUSTRIAL ENTERPRISES
Authors:   Zhytomyr Polytechnic State University, Kuchuk Anna
Published: October 2022

Historical analysis shows that the military economy is characterized by high dynamism and uneven development. In the last century, military-economic activity in various countries of the world underwent deep shifts, which led to the transformation of methods of economic support for military construction. Profound changes in the nature of the state's military needs demanded a transition to a new type of military economy, fundamentally different from the former in terms of basic qualitative and quantitative parameters, the system of organization and management, forms of relationships with the military organization of the state, the general economy and other areas of social activity. Economic analysis in the management system of production costs of large industrial enterprises has an undeniably significant value, which is manifested in the provision of relevant information about cause-and-effect relationships in the behavior of costs and the effectiveness of their management. "Economic analysis is the most important component of economic sciences, it decisively determines the reliability and reliability of the conclusions drawn in relation to the state, development prospects and efficiency of business entities of various levels. The current state of economic analysis characterizes it as a theoretically well-developed science. The methods of analysis created in previous periods are being adapted and improved to the new economic conditions. However, analytical science is in a state of development, which is determined by objective reasons related to changes in the economy (expansion of the independence of economic entities in the implementation of their activities, shifting of priorities towards the interests of company owners, etc.). In general, it can be said that analytical science is in a state of development, the methods of analysis of the use of the economic potential of enterprises, production of products, their cost price, and the financial condition of enterprises developed in previous periods require clarification, addition and adaptation to new business conditions. The wars of the last century prompted scientists from different countries to study the state of the economy during the period of war. As the experience gained in the 20th century shows, wars are won not only by a strong army, but also by an equally strong economy. And the military economy, in turn, needs an effective management mechanism, which is formed based on the study of practical and theoretical experience. Therefore, the study of the issue of war economy is very important and especially relevant in our time.
ORGANIZATION OF ACCOUNTING OF EVACUATION OF INDUSTRIAL ENTERPRISES
Authors:   Zhytomyr Polytechnic State University, Kuchuk Anna
Published: October 2022

The article describes the theoretical and methodological features of accounting for the evacuation of industrial enterprises. It was determined that the accounting system plays an important role in the formation of information support for the management of the process of evacuation of industrial enterprises from occupied territories or territories of hostilities. Considering the specifics of the object under study, there is a need to justify new approaches to the organization of accounting for the process of evacuation of an industrial enterprise. Yes, there is a need to identify the subjects of the organization and management of the evacuation process, as well as the subjects of the organization and accounting; establishment of accounting organization stages; determination of responsibility for accounting; organization of primary registration at all stages of evacuation; determination of the form of reporting on enterprise evacuation processes; organization of activities of the accounting service in safe territories; organization of information and communication links; development of a working plan of accounts. The definition of the peculiarities of the accounting organization is related to the accounting system that has developed in Ukraine and allows for the presence of several subsystems that have their own characteristics. We can see the reflection of these changes in the legislative acts and regulatory documents of the state, taking into account the peculiarities of business, formalized in the accounting of industrial enterprises. The accounting of the business structure must contain alternative options for the economic accounting of the evacuation, which is fixed by the order of the enterprise. It is worth noting that the size of the business structure and the scope of its activities largely determine the share of one or another type of accounting. Accounting for the evacuation of industrial enterprises as a specific element of the accounting system should create an organizational and methodological environment. The issue of the organization of accounting for the evacuation of industrial enterprises, in the sectoral aspect, is not sufficiently covered in the scientific literature, therefore there is a need for a theoretical justification and development of models for the organization of accounting at industrial enterprises with the determination of the structure, scope, terms and forms of submission of information for management, which is gaining relevance in a post-industrial society.
НАУКОВИЙ ДОРОБОК ДОСЛІДЖЕНЬ ПРОБЛЕМАТИКИ ВТРУЧАННЯ В ДІЯЛЬНІСТЬ ЗАХИСНИКА ЧИ ПРЕДСТАВНИКА ОСОБИ
Authors: Русанівська Д. Д.
Published: October 2022

Дана наукова стаття присвячена науковому доробку досліджень проблематики втручання в діяльність захисника чи представника особи шляхом узагальнення та систематизації результатів фундаментальних наукових досліджень вітчизняних та іноземних вчених. Крім цього детально проаналізовано наукові розвідки з досліджуваної проблематики, викладених у наукових статтях, посібниках. З метою поглибленого вивчення проблематики втручання в діяльність захисника чи представника особи обрано логічний принцип викладу матеріалу, який дає можливість висвітлити концептуальні ідеї та погляди. Аналіз вказаної проблематики розпочато із становлення процесуального статусу захисника та представника особи у кримінальному процесі. Продовжено розглядом процесуальних особливостей участі захисника як суб’єкта кримінального провадження. Також звернута увагу і на дослідженнях, що стосуються захисту прав потерпілих та викликають певний інтерес. Не залишено поза увагою і дослідження, які стосуються процесуального становища потерпілого як суб’єкта кримінально-процесуального доказування на різних стадіях кримінального провадження, адже за досліджуваною категорією кримінальних проваджень, захисник чи представника особи виступає потерпілим. Питання процесуального статусу захисника чи представника особи розглянуто кримінальною процесуальною доктриною, іншим напрямком виступає – втручання в їх діяльність, що розглянуто з позиції кримінального права в контексті кримінально-правової характеристики, кримінальної відповідальності, а представники криміналістики таку тематику не порушували, що зумовило відсутність методики розслідування втручання в діяльність захисника чи представника особи й ускладнило протидію цьому негативному явищу з боку підрозділів Національної поліції України.
Increasing mathematics students' involvement in research activities at teacher education universities
Authors: Vlasenko Kateryna , Rovenska Olha , Lovianova Iryna , Kondratyeva Oksana , Achkan Vitaliy
Published: October 2022

The paper explores the problem of creating interest in mathematics students' research endeavors at teacher preparation institutions. The purpose of the study is to determine whether it is possible to organize students' scientific investigation using the 5E Instructional Model during a workshop on approximation theory and the Fourier series. The study takes into account the survey responses from the students who assisted in assessing the workshop participants' emotional states. The Differential Emotion Scale, a tool for expressing evaluations of positive and negative emotionality, was used to gather the data. The benefits of the atmosphere created by the 5E Instructional Model on students' emotional states and how it shapes their motivation in scientific inquiry when setting up workshop classes are covered in the article. We have reason to believe that running workshops based on the 5E Instructional Model is effective. The students' involvement throughout the session and enthusiasm in research activities increased as a result of the index reduction of their negative feelings.
Surviving a Coma? Türkiye-EU Relations in Times of Crises (2005–2022)
Authors: İçener Erhan
Published: October 2022

Türkiye’s EU membership negotiation process has been comatose since its early years. Now, in 2022, the seventeenth year of negotiations, the final destination of Türkiye’s EU journey is still far from certain. And recent debates on Türkiye–EU relations focus on whether Türkiye should be an EU member rather than why or when. There has been increasing criticism directed at each other and waning interest in Türkiye’s EU integration while the EU and Türkiye have faced major crises in the last two decades. This article aims to analyse key factors and issues influencing Türkiye’s EU accession process on the road to the current stalemate since the beginning of accession negotiations in 2005: (a) the Europeanisation of the Cyprus issue (the role of EU Member States and conditionality), (b) deEuropeanisation in Türkiye (the role of conditionality), (c) the return of geopolitics (the role of security considerations and contextual changes), and (d) the July 15th failed coup attempt (the role of conditionality and contextual changes). It finally explores the EU’s commitment to enlargement and debates on its alternatives (the role of Member States, and EU institutions and narratives).
A Strategic Base in the Global Supply Chain: Türkiye
Authors: Aydın Kenan
Published: October 2022

Türkiye is becoming a new base in the global supply chain due to its geopolitical position and the cost advantages it provides. Due to the COVID-19 outbreak, logistics problems, especially production and transportation costs, have further strengthened Türkiye’s position in this context. Türkiye’s strategic location, strong logistics infrastructure, costeffective and qualified workforce, along with a liberal investment climate, offer a suitable environment for international companies. Türkiye ranks well
in the World Bank’s Logistics Performance Index, which evaluates countries’ logistics performance in customs, transportation, and infrastructure. Türkiye has served as a bridge between the east and west since historical times. During the Seljuk period, caravanserais and other infrastructure and service areas were established in Anatolia to support commercial activities. The Silk Road, which had an important place until a certain period of the Ottoman Empire, lost its importance due to other developments.
The “One Belt One Road Project” initiated by China, still in progress and planned to be completed in 2049, will make Türkiye even more important in terms of the global supply chain in the next 10 years. İpekyolu follows the northern and southern routes in Anatolia. With China’s “One Belt One Road Project”, the Silk Road will regain its former importance as the “Modern Silk Road”. Chinese President Xi Jinping fi rst mentioned the Land and Sea Silk Road project in one of his speeches in 2013. It has been decided to name these
two projects as the “Belt and Road Initiative-BRI” or the “One Belt One Road-OBOR” project. The word belt constitutes the land route of the project, which includes highways, railways, oil and natural gas pipelines, and infrastructure investments. The word road includes the sea routes covered by the project. The routes of these corridors are provided by multidimensional corridors in the direction of Asia-Europe instead of a single route. Within the scope of this project, many infrastructure investments are made in Türkiye as well. In this study, the cost advantages that Türkiye will provide to the global supply chain will be evaluated due to both its cost and geographical location and the infrastructure investments made.
节能低碳技术在污水处理中的应用
Authors: 沈 建
Published: October 2022

经济的快速发展也引发了各方面的问题，其中环境污染问题是现阶段亟待解决的问题之一，尤其是水环境污染问题已经成为环境污染中的主要问题。我们都深刻的知道，水资源与人们的生存发展有着非常重要的联系，如果没有做好水污染处理工作会给生态环境带来非常不利的影响，同时也给人们日常生活添加烦恼，因此应充分认识到污水处理工作的重要性，并将节能低碳技术应用到污水处理过程中，在保证污水处理效果的基础上减少处理过程中二次污染问题。
环保工程中污水处理工艺及方法探究
Authors: 金 超
Published: October 2022

在城市发展过程中会产生大量的污水，而污水对人们生产生活会产生很大的影响，严重的话还会威胁到人们的身体健康。而且从我国的生态环保现状来看，我国污水处理问题在变得日益加剧，虽然这一问题已经得到了相关部门以及社会的关注，但是污水废水处理问题依旧没有得到有效的控制。因此需要将污水处理与现代环保措施进行深入的结合，不断加大污水治理的力度和爆出措施，由此来为人们提供更加安全的用水资源，对城市的发展，社会的进步做出更大的贡献。因此在本文中我们主要对环保工程中污水处理工艺及方法进行了深入的分析与探讨，以供参考。
建筑施工图审查及设计中常见问题研究
Authors: 卢 静静
Published: October 2022

在施工过程中，施工图设计是施工的先决条件，它对保证施工质量和降低施工成本起着非常重要的作用。但鉴于目前设计计划的实际情况，在实际设计过程中显然出现了一些问题。在此基础上，结合正在施工的施工图找出存在的问题，提出具体的设计原则和应对措施，带动施工图设计的快速发展。
建筑工程中土建施工现场管理的优化策略
Authors: 李 晨旭
Published: October 2022

通常建筑工程土建施工现场的工作环境较为复杂，若不进行相应的规范管理，就会导致工作秩序越发混乱，引发较为严重的安全问题，最终影响到整个建筑工程的质量。因此就需要对建筑工程土建施工现场做好监督管理工作，才能保证建筑工程土建施工能够顺利稳定进行开展。提高建筑工程土建施工现场管理的工作力度，是确保整体建筑工程的基础，对于促进建筑行业发展以及提升国民经济可持续发展，具有良好的促进作用。对此，加强建筑工程土建施工现场监督管理，在提升施工建设质量与提升工作人员整体素质有重要的意义。
建筑工程中施工技术及现场施工管理的探究
Authors: 陈 志涛
Published: October 2022

随着城市建设的不断扩展，建筑施工企业面临更加严峻的形势，若想在竞争如此激烈的市场占有一席之地，就要根据自身发展状况以及市场需要进行相应的改革。因此目前建筑企业应提升建筑施工技术的操作的规范性，保障现场施工管理工作的顺利展开，发挥施工技术的引导效能，构建与建筑施工需要相符的管理体系，以此提升工程的施工质量，强化企业市场竞争力。
浅谈全过程管理模式在工程项目中的应用
Authors: 田 帝
Published: October 2022

经济发展迅速，大规模工程项目数量增多，传统管理模式管理效果难以达到项目建设质量需求，阻碍工程项目发展。文中将结合全过程管理模式的管理理念，从项目前期管理、施工过程管理、成本造价管理与竣工管理四方面探究全过程管理模式在工程项目中的运用方式，强化工程项目管理力度，提高工程项目的质量。
新形势下城市园林绿化工程技术与应用探讨
Authors: 刘 祥军 , 郭 静 , 李 建华 , 张 楠 , 李 晓华
Published: October 2022

在社会进步和人们生活质量提高的新形势下，人们的生活环境也发生了变化，对于城市内环境的绿化提出了更高、更新的要求。园林绿化工程是城市建设中关于环境绿化的重要项目，而工程的最终成效与施工技术密切相关，需要工程单位通过技术分析，全面提升工程效率和质量，为人们创造更加宜居的环境。鉴于此，本篇文章围绕城市园林绿化工程项目实际情况，简述了新形势下开展该项工程的意义和工程自身的特点，重点从七个方面分析了工程中相关技术的应用要点，以期为相关工作人员提供参考。
有效提升建筑工程施工技术管理水平的方法
Authors: 田 立慧 , 魏 继巍
Published: October 2022

现如今建筑工程项目不断增多，规模呈现逐渐扩大的趋势，各种先进的技术应用于建筑工程管理中，这对管理人员的综合能力提出更高要求。为了进一步提升建筑工程技术管理水平，文中在明确施工技术管控重要性的前提下，总结分析了当前技术管理常见的不足，进而提出优化施工技术管理的建议，希望通过本文分析可以为相关管理者提供参考。
体育中考背景下体能训练在体育课堂教学中的应用研究
Authors: 宋 思雨
Published: October 2022

近几年来，我国青少年体质水平连年下滑，我国强化学校体育工作，通过新政策的改革体育课程和体育分数的不断增加，将体能训练纳入体育课堂中，提高体育教师的教学质量和效率，同时也提高学生的身体素质。文章通过对体育中考背景下体能训练在体育课堂教学中的应用展开研究，找出体育课堂中存在的不足并提出相关建议，完善中学体育教学中体能训练的方法和相应对策，为后续开展体能训练打下基础。
建筑施工企业会计集中核算中财务管理的探讨
Authors: 袁 川明
Published: October 2022

现如今我国整体经济增长速度越来越快，城市建筑的数量也在不断增加，使得市场竞争变得极为激烈。施工企业为了能够获取更高的经济收益，理应做好财务管理工作，特别是会计集中核算，更是重中之重。只有处理好所有细节部分，才能确保各项工作顺利推进，为企业的发展提供帮助。本篇文章主要描述了集中核算的意义，探讨了建筑施工企业会计集中核算财管存在的问题，分析了现有的基本条件和应用的实际情况，并对于财务管理的主要策略发表一些个人的观点和看法。
企业会计核算工作优化发展对策
Authors: 李 友爱
Published: October 2022

财务工作中非常重要的一项任务就是会计核算，同时财务发展也要建立在会计核算工作上。近些年我国市场经济持续发展，这为企业的发展创造了有利条件，同时企业之间的竞争也日渐激烈。在企业管理中，只有更加准确地、灵活地完成会计核算工作才能获取不同维度的数据信息，才能为管理者制定决策提供数据支撑。为了进一步发挥会计核算在企业管理中的作用，文章首先明确了会计核算工作的重要性，分析了当前企业会计核算中常见的一些不足之处，并且提出了优化建议。通过本文的研究，有助于相关工作者进一步改进会计核算工作，提高工作水平。
加强企业会计核算提升财务管理水平
Authors: 张 磊
Published: October 2022

随着科学技术的迅速发展，信息时代的来到，企业会计需要核算的数量也越来越度多，其中涉及比较多的就是金融交易，此外就是企业纳税资质审核方面的内容，基于此，就需要不断提高会计基础工作能力，并且对会计核算方面的内容进行科学有效的整合。要更好的提供财务管理水平，还需要从管理层角度来对财务会计工作任务是否符合相关规范标准来进行有效的分析，由此找到改进和优化企业会计核算方法的措施。
财务会计向管理会计转型的路径探究
Authors: 李 雯
Published: October 2022

管理会计着力于为企业提供最优决策，改善企业的运营管理，提高其经济效益服务。管理会计在企业运营管理中发挥着至关重要的作用。随着我国的管理会计从传统会计中脱颖而出，发展比较晚，存在理论基础和实践经验不足的问题。并且企业之间的竞争也是非常激烈。因此，企业想要获得长期稳定的发展，除了不断进行产品、技术和服务创新外，还应当充分发挥管理会计的作用，为企业内部管理者提供及时有效的经营决策信息。
企业人力资源培训及优化策略研究
Authors: 陈 艳
Published: October 2022

当前企业持续进步和发展，人力资源（Human Resource，简称HR）作为企业发展重要组成，在企业经营发展中发挥着重要的作用。在人力资源管理活动中，人力资源培训活动全面落实可以为企业持续输送人才，为企业持续发展贡献坚实基础。在企业人力资源培训活动中，培训方式多种多样，很多企业在进行人力资源培训时存在很多问题，这些问题存在会对企业资源造成损耗，对企业总体经营效率产生影响。基于此，文章就企业人力资源培训及优化策略展开研究，希望可以促进企业人力资源培训工作进步和发展。
浅谈高校科技成果转化现有问题及对策
Authors: 梅 特
Published: October 2022

根据科技部《2021全国技术市场统计年报》，高校成果转化规模低于预期，而武汉市既是高校众多的城市又是全国成果转化的高地，故以武汉市技术市场的交易数据对高校科技成果转化的问题进行分析并提出相应的对策。
试论人工智能发展对会计专业人才需求的影响
Authors: 凌 静
Published: October 2022

随着人工智能在会计领域的应用,加速了会计职能的转型｡我国会计的发展与演进经过了四个时期：手工会计､电算化会计､信息化会计和智能化会计｡相应的会计职能也逐步由会计核算与监督转变到会计管理与控制,再转变到财务管理与决策｡会计职能的变化将深刻地影响到会计专业的人才,对低级会计人员的需求将急剧下降,同时由于会计职能的转移,对高级会计人员的需求也会随之增长｡
基层审计机关深化资源环境审计研究
Authors: 董 天骄
Published: October 2022

十九大报告提出建设生态文明，资源环境审计日益成为环境治理体系的重要组成部分。然而，基层审计机关资源环境审计仍处于初试阶段，需要进一步通过加强理论建设、构建协同机制、科学规划、创新工作方式等途径不断深化资源环境审计。
国企改革背景下的人力资源管理思考
Authors: 阮 晓敏 , 钟 娜 , 李 海琴 , 肖 泱 , 陈 晨
Published: October 2022

2021年，按照公司2021年工作会要求和部署，结合部门实际，立足部门职责，突出抓好各项工作计划的落实和部门自身党风廉政建设，努力提升人力资源管理工作水平。文中对国企改革背景下人力资源管理存在的问题进行综合性分析,并提出相关完善建议,以供参考。
浅谈企业党政思想工作建设现状及优化建议
Authors: 宣 璇
Published: October 2022

任何企业在发展的过程中，都必须充分考虑当前的社会状况，结合当前的形势，制定一系列的发展措施。党和政府的思想宣传工作也是其中的重要组成部分。只有做好党政思想工作，企业才能充分发挥自身优势，团结职工，激发企业发展动力。只有把企业的整体思维统一起来，才能进一步促进企业的发展。在经济快速发展的社会形势下，党和政府的思想宣传工作必须结合企业实际，发挥作用，进一步促进企业的快速发展。
论提高我国旅游经济效益的意义和主要途径
Authors: 张 立涛
Published: October 2022

旅游业是促进我国社会经济发展的重要行业，在21世纪的经济建设道路中，国内各地区致力于通过建设优秀的旅游生态环境，来为地区的旅游业提供良好的基础条件，使得其他地区纷纷效仿，这也就造就旅游业所对应的经济效益不断上升的发展趋势。基于此，本篇文章将通过分析旅游业发展的原则与现状，来总结提高旅游业经济效益对于地区发展的重要性，并且结合现状来分析优化旅游业发展的有效途径。
社会经济网络视域下的当代翻译研究
Authors: 毛肯 乔丽潘 ·
Published: October 2022

在一个特殊的历史发展时期，翻译行为的持续和创新催生了大量民间作品和可持续翻译传统。因此，即使在今天，翻译技能和技术仍在不断发展，这只会延长前任的工作时间，只会加强创新和实践。唯一保持不变的是对原文的尊重，即所有翻译最终都必须以目标受众为对象，并向他们提供全部或部分信息。即使在这一过程中，原语文的地位也没有得到应有的重视，但为了对公众负责，这一规则正在得到越来越多的承认。根据这一规则，翻译的目的是确定翻译的行为，保持文本的功能，同时遵守一致性和忠实性原则，并在必要时选择适当的翻译技术，以提高信息传播的效率。随着当今人类社会的发展，经济已成为社会活动中不可或缺的主题，特别是随着国民经济的发展、国际经济交流的加强以及报刊、广播、电视、因特网、移动通信等的参与。不同区域和语言的经济新闻影响到世界各国人民。
BCMA loss in the epoch of novel immunotherapy for multiple myeloma: from biology to clinical practice
Authors: Zhou Xiang , Rasche Leo , Kortüm K. Martin , Mersi Julia , Einsele Hermann
Published: October 2022

The treatment of multiple myeloma (MM) is evolving rapidly. In the past few years, chimeric antigen receptor modified T cells and bispecific antibodies are bringing new treatment options to patients with relapsed/refractory MM. Currently, B-cell maturation antigen (BCMA) has emerged as the most commonly used target of T-cell-based immunotherapies for relapsed/refractory MM. Clinical data have demonstrated promising efficacy and manageable safety profiles of both chimeric antigen receptor T-cell and bispecific antibody therapies in heavily pretreated relapsed/refractory MM. However, most patients suffer from relapses at later time points, and the mechanism of resistance remains largely unknown. Theoretically, loss of antigen is a potential tumor-intrinsic resistance mechanism against BCMA-targeted immunotherapies. Strategies to overcome this kind of drug resistance are, therefore, needed. In this review, we discuss the loss of BCMA in the new epoch of immunotherapy for MM.
Three-year results from phase I of ZUMA-4: KTE-X19 in pediatric relapsed/refractory acute lymphoblastic leukemia
Authors: Wayne Alan S. , Huynh Van , Hijiya Nobuko , Rouce Rayne H. , Brown Patrick A. , Krueger Joerg , Kitko Carrie L. , Ziga Edward Dela , Hermiston Michelle L. , Richards Michael K. , Baruchel Andre , Schuberth Petra C. , Rossi John , Zhou Lang , Goyal Lovely , Jain Rajul , Vezan Remus , Masouleh Behzad Kharabi , Lee Daniel W.
Published: October 2022

Here we present the 3-year results of ZUMA-4, a phase I/II multicenter study evaluating the safety and efficacy of KTEX19, an autologous anti-CD19 chimeric antigen receptor (CAR) T-cell therapy, in pediatric/adolescent patients with relapsed/refractory B-cell acute lymphoblastic leukemia. Phase I explored two dose levels and formulations. The primary endpoint was the incidence of dose-limiting toxicities. Thirty-one patients were enrolled; KTE-X19 was administered to 24 patients (median age 13.5 years, range 3-20; median follow-up 36.1 months). No dose-limiting toxicities were observed. All treated patients had grade ≥3 adverse events, commonly hypotension (50%) and anemia (42%). Grade 3 cytokine release syndrome rates were 33% in all treated patients, 75% in patients given the dose of 2×106 CAR T cells/kg, 27% in patients given the dose of 1×106 cells/kg in the 68 mL formulation, and 22% in patients given the dose of 1×106 cells/kg in the 40 mL formulation; the percentages of patients experiencing grade ≥3 neurologic events were 21%, 25%, 27%, and 11% respectively. Overall complete remission rates (including complete remission with incomplete hematologic recovery) were 67% in all treated patients, 75% in patients given 2×106 CAR T cells/kg, 64% in patients given 1×106 cells/kg in the 68 mL formulation, and 67% in patients given 1×106 cells/kg in the 40 mL formulation. Overall minimal residual diseasenegativity rates were 100% among responders; 88% of responders underwent subsequent allogeneic stem-cell transplantation. In the 1×106 (40 mL) group (recommended phase II dose), the median duration of remission censored at allogeneic stem-cell transplantation and median overall survival were not reached. Pediatric/adolescent patients with relapsed/refractory B-cell acute lymphoblastic leukemia achieved high minimal residual disease-negative remission rates with a manageable safety profile after a single dose of KTE-X19. Phase II of the study is ongoing at the dose of 1×106 CAR T cells/kg in the 40 mL formulation. ClinicalTrials.gov: NCT02625480.
Treatment patterns and outcomes in relapsed/refractory follicular lymphoma: results from the international SCHOLAR-5 study
Authors: Ghione Paola , Palomba M Lia , Ghesquieres Hervé , Bobillo Sabela , Patel Anik R , Nahas Myrna , Kanters Steve , Deighton Kevin , Hatswell Anthony , Ma Long , Limbrick-Oldfield Eve H. , Snider Julia Thornton , Wade Sally W. , Riberio Maria Teresa , Radford John , Beygi Sara , Gribben John
Published: October 2022

The SCHOLAR-5 study examines treatment patterns and outcomes of real-world follicular lymphoma (FL) patients on 3rd line of treatment (LoT) or higher, for whom existing data are limited. SCHOLAR-5 is a retrospective cohort study using data from adults (≥ 18 years) with grade 1-3a FL, initiating ≥3rd LoT after June 2014 at major lymphoma centers in the US and Europe. Objective response rate (ORR), complete response (CR), progression-free survival (PFS) and overall survival (OS) were analyzed by LoT. Time-to-event outcomes were assessed using Kaplan-Meier methods. Of 128 patients, 87 initiated 3rd LoT, 63 initiated 4th LoT, and 47 initiated 5th LoT. At 1st eligible LoT, 31% progressed within 24-months of 1st LoT anti-CD20 combination therapy, 28% had prior autologous stem cell transplantation, and 31% were refractory to the previous LoT. The most common regimen in each LoT was chemoimmunotherapy; however, experimental drugs were increasingly used at later LoT. In the US, anti-CD20 monotherapy was more common at ≥3rd LoT compared to Europe, where stem cell transplants were more common. ORR at 3rd LoT was 68% (CR 44%), but decreased after each LoT to 37% (CR 22%) in ≥5 LoT. Median OS and PFS at 3rd LoT were 68 and 11 months, respectively, and reduced to 43 and 4 months at ≥5 LoT. Treatments were heterogenous at each LoT in both the US and Europe. Few FL patients achieved CR in later LoT, and duration of response and survival diminished with each subsequent line.
Frequency of Meningitis Among Infants and Young Children With Clinically Diagnosed First Time Febrile Seizure
Authors: Mahamuduzzaman Abu Shoyeb Md , Banu Nazneen Akhter , Anowar Asma Bint , Hossain Mohammad Delwar , Karim Farhana , Qyuoom Md Abdul , Saleha Rawshon
Published: October 2022

Background: Patients with bacterial meningitis (BM) frequently present with febrile seizures (FS) without any signs or symptoms of BM. To perform a lumbar puncture on all FS patients to rule out meningitis is still debatable. The goal of this study was to estimate the frequency of meningitis among first-time febrile seizures (FTFS).
Methods: From July 2013 to June 2014, a cross-sectional study was conducted at Sir Salimullah Medical College and Mitford Hospital, Dhaka. CSF and blood reports and detailed histories and examinations were examined in children aged 6 months to 36 months with FTFS (simple or complex).
Results: The first complex febrile seizure (FCFS) and the first simple febrile seizure (FSFS) occurred in 58% and 42% of the 73 children included in this study. 11 (15%) cases had meningitis based on CSF and blood reports, where 2 (3%) had confirmed BM, 2 (3%) had probable BM, and 7 (10%) had viral meningitis (PVM). One of two children with confirmed BM had Klebsiella spp. in CSF culture and Streptococcus pneumoniae in CSF gram stain. Others with probable BM had CSF pleocytosis with low sugar and high protein levels. Leukocytosis was found in all four children with BM. Two of the seven children with PVM had isolated pleocytosis, one had low sugar, and four had high protein CSF. Blood cultures were negative in all 11 meningitis cases.
Conclusion: Although meningitis is common in FCFS, this study found no cases of BM children with FSFS, though PVM was not uncommon.
Sir Salimullah Med Coll J 2022; 30: 108-114
Evaluation of Blood Requisition Forms Submitted to Transfusion Medicine Department of a Tertiary Care Hospital in Dhaka, Bangladesh
Authors: Biswas Daanish Arefin , Wasim Md , Bhuiyan Hasiba Akhter , Nabi Quazi Md Rashid Un
Published: October 2022

Introduction: Blood requisition form (BRF) analysis is one of the most efficient and effective approaches to assess and monitor rational use of blood and its product. BRF is the first line of communication between the clinicians and transfusion medicine specialists which helps to recognize and evaluate inappropriate use of blood. This issue is frequently underrated by the clinicians which results in increased risk of inappropriate transfusion. The current study is aimed to examine the pattern of completion of blood requisition forms and to ensure safe blood transfusion.
Materials and methods: This cross sectional prospective study was conducted from January 2020 to December 2021, at the Department of Transfusion Medicine, Sir Salimullah Medical College Mitford Hospital, Dhaka, Bangladesh. A total of 32,133 blood requisition forms that were submitted during the study period were compiled and reviewed anonymously. The data were analyzed using Microsoft Excel.
Results: During the study period, a total of 32,133 Blood requisition forms were analyzed. Only 15.2% of these forms were duly completed. Rest of the forms had one or more important parameters left blank. The most common incomplete BRF items were the clinical history or differential diagnosis of the patient (52.66%), presumed date and time of transfusion (95.19%), previous transfusion history (95.9%), and referring doctor’s name and designation (88%). Blood requests were more for females (52.02%) than males (47.98%) during the period. Requisitions were more for adults (90%) than pediatric patients.
Conclusion: The current study provides evidence that the rate of completion of BRFs is not satisfactory. The request forms evaluated were not covering acceptable demographic and clinical data of the patients. Both the Hospital Transfusion Committee (HTC) and the Department of Transfusion Medicine can help to improve and standardize transfusion practice by working together.
Sir Salimullah Med Coll J 2022; 30: 142-147
Disease Pattern of Musculoskeletal Disorders of the Patients Attending Outdoor of the Department of Physical Medicine and Rehabilitation, Sir Salimullah Medical College, Dhaka
Authors: Banik Amitav , Amin Md Ruhul , Rashid Md Harun Or , Saha Himadri Shekhor , Rahman Anisur
Published: October 2022

Background: Physical medicine and rehabilitation (PM&R) is a medical speciality focused on prevention, diagnosis, rehabilitation, and therapy for patients who experience functional limitations resulting from injury, disease, or malformation. Department of Physical Medicine and Rehabilitation (PMR) at Sir Salimullah Medical College and Mitford Hospital provides outdoor services for different musculoskeletal and neurological disorders which include counseling, drug management, physical therapy, speech therapy, ADL training etc. In this study, we enrolled only the patients of musculoskeletal disorders.
Objectives: To understand the disease pattern and demographic characteristics of the patients of Musculoskeletal disorders presenting to the department of PMR. This will increase the awareness regarding PMR services among doctors and other health care providers and also to facilitate rehabilitation plan of a musculoskeletal disorder.
Methods: This cross-sectional observational study was done on outdoor patients attending the Department of PMR at Sir Salimullah Medical College from 1st January, 2021 to 31st December, 2021. We have enrolled only the patients of musculoskeletal disorders.
Results: Total number of patients was 13644, most of them were female. Maximum number of patients belong to 20-50 years of range and they mainly come from surrounding urban areas. Regarding the musculoskeletal disease pattern, 34.2% patients presented with mechanical low back pain (LBP) and related diseases, 11.4% patients with neck pain, 13.7% with knee pain, 9.4% with shoulder pain, soft tissue rheumatism (STR) comprises of 8.7%, 4.6% with heel pain and related disorders, 14.3% with rheumatological diseases, other musculoskeletal diseases contribute to 3.7%. Patients with LBP and related diseases were diagnosed as non-specific mechanical LBP (74%), Herniated disc disease(5%), Lumbar spondylosis, Spondylolisthesis (2%), etc.
Conclusion: LBP and related diseases affect most of the people attending outdoor with musculoskeletal diseases.
Sir Salimullah Med Coll J 2022; 30: 186-189
PROTECTION OF THE RIGHT TO HEALTH DURING THE PERIOD OF ARMED CONFLICT: THE EXPERIENCE OF UKRAINE
Authors: Mykhailichenko Tetiana , Zabuha Yuliia
Published: October 2022

This article deals with the protection of the right of the civilian population and medical workers to health. The issue of rights violations arises in connection with the armed conflict between the Russian Federation and Ukraine, which has been ongoing since 2014. On 24 February 2022, its second phase began, which has been characterised by a large-scale offensive by the Russian army. The hostilities are still ongoing, and some areas are temporarily occupied.
The aim of the present paper is to reveal the essence of the main international legal, and national means of protecting the right to health in a period of armed conflict.
Methods. A combination of general scientific and special scientific approaches was used, as well as a number of methods, namely: dialectical, comparative, analytical, synthetic, and complex methods and the method of generalisation.
The results of the study have proved that the existing system of regulatory and institutional means of protection of human rights to health, both at the international and national level, is not able to do this successfully.
Conclusions. The right to health in the current period of the armed conflict is limited legally and forcibly for those who stay in the rear by the state on whose territory the armed conflict continues. It is illegal when one of the parties to the conflict violates IHL norms. Despite the normative means of ensuring and protecting the right to health and a wide range of institutional protections established by the parties to the armed conflict – Ukraine and the Russian Federation – the existing system is unable to protect the right of civilians to health. First of all, this is due to the Russian Federation’s violation of the established IHL rules. At the same time, the lack of a quick and effective protection mechanism leads to the fact that civilians, and sometimes medical workers, increasingly feel defenceless against aggressors. Therefore, it seems that the world community should review the existing approaches and establish more effective means of protecting human rights, including the right to health.
Hazardous Effluents and their Impacts on Human Health: Future of Industrial Boom
Authors: Rashid Muhammad Tayyab , Aslam Rana Waqar , Abbas Waqas , Khalid Muhammad Burhan , Arshad Salman , Mirza Ali Imam , Tahir Muhammad Hussain , Ullah Hameed
Published: October 2022

Industries, being commercial productive units perform as manufacturing agents to produce large quantity of goods to cater the needs of increasing population. Manufacturing units use raw material and goods to deliver the final product. The findings of this research are consistent and reliable. The study area mainly consists of three types of industries including iron and steel, chemical and fertilizer and plastic industry. The hazardous waste generated by industries in Pakistan was computed as 1 lac tons per day and more than 10 thousand tons/day in Lahore. These wastes played a vital role in the degradation of environment. In addition, various harmful gases such as fluoride, carbon monoxide and dust were released by these industries which mixed with fog and caused smog that resulted in respiratory diseases and the Lahore remained in smog for last 3 years. The air quality declined to alarming level because of the dust produced by these industries. Air pollution leads to skin problems, and respiratory diseases among residents living in outskirts of these industries. In this research it is estimated that industrial emission is more dangerous than any other emissions. From the year 2008 to 2019 the harmful emissions were categorized as 43% by transport sector, 25% by industries, 20% by agricultural sector and 22% by power sector. Proper planning and management is required to secure the safety of environment from the adverse effects of industries.
A Study of Awareness and Practices in Pakistan’s Software Industry towards DevOps Readiness
Authors: Saleem Khadija , Khan Muhammad Sohail
Published: October 2022

There are regular conflicts between the traditionally divided software organization i.e. dev and ops teams during the software development process for delivering the software to the end-user. DevOps overcome these conflicts by automating the processes between the development and operations team in such a way that they can build, test, and release the software successfully and efficiently to the end-user. Globally, more and more organizations are adopting DevOps. As Pakistan’s software industry is progressively growing while DevOps is a relatively new concept, there is a need for DevOps awareness and understanding towards its adoption and practices. This paper evaluated DevOps awareness and identified the practices adopted in Pakistan’s software organizations and suggested generic guidelines for DevOps transition. A questionnaire-based survey is conducted to collect data and various DevOps sub-activities being practiced. The survey analysis and results depicted that Pakistan’s Software Industry is making efforts towards the adoption of DevOps but due to lack of its awareness, most of the DevOps practices are not fully adopted yet. According to the DevOps evolution model, only one-eighth of Pakistan’s software organizations are at the self-service stage, while the rest of them are still struggling at the normalization and standardization stage.
A Evaluation of tectonic geomorphology of Awaran in Baluchistan, Pakistan using SRTM data.
Authors: Baqi Abdul , Jamal Tabasam
Published: October 2022

An earthquake of September 24, 2013 with a magnitude of 7.7Mw destroyed extensive region of Awaran district located in province Baluchistan in southern Pakistan, the earthquake was nearly 10km deep below the surface of earth. This convulsion brought a havoc in the inaccessible and remote regions and victimized nearly 810 families. This tremor destroyed the non-engineered human structure within 100 km of the earthquake which caused tremendous loss of human lives. In this paper Digital elevation model (DEM) was utilized to study active deformation and mapped the isobase, relative relief, drainage density incision and vertical dissections which indicates that Awaran Fault sinisterly active in NNE-SSW direction and the deformations were highlighted. The high value of drainage density was observed on northern east and in the central region of southern west region of Awaran district. The drainage density is elevated by accelerated erosion in surrounding region. DEM and remote sensing tools proved efficient to study the region efficiently.
Isolation of Keratinolytic from Chicken (Gallus gallus domesticus) Farms and Assessment of their Efficacy in Feathers Degradation
Authors: Bokhari Shazia , Yasmeen Roheela , Qurashi Aisha Waheed , Habib Samiya , Rafi Uzma
Published: October 2022

Keratinolytic microorganisms and their enzymes are associated with poultry feather degradation. In the present study feathers of Gallus gallus domesticus (chicken) and surrounding dry soil was collected from a private poultry sheds located in Jahman village near Lahore. Bacteria were isolated by using enrichment techniques and screened for their proteolytic activity on skim agar. Isolated Bacteria were colonially, morphologically and biochemically characterized and named as SNC1, SNC2, SNC3, SNC4, SCH1, SCH2, SCH3 and SCH4. Results showed closed similarity of bacterial isolates with bacillus species. Effect of various media (LB-broth and Nutrient broth), pHs (7 and 8) and temperatures (4, 37, and 50℃) were recorded on bacterial growth and feather degradation. Bacterial cell densities and amount of keratin produced per gram feather weight were high at temperature 50℃ and pH 8.0. The feather degradation by bacterial isolates was confirmed at different time intervals using stereomicroscopes. The protein analysis of G. gallus domesticus feathers showed protein contents of 3.125g/100 ml. It was concluded high temperature and alkaline pH favored keratin production by bacterial consortia. Moreover, the bacterial isolates used in the current study have the potential to degrade poultry feather waste and extracted keratin is found to be promising for further exploitation of poultry waste.
Evaluation of Catastrophic Global Warming due to Coal Combustion, Paradigm of South Asia
Authors: Ahmad Hafiz Haroon , Saleem Farhan , Arif Hania
Published: October 2022

Coal is a carbon containing non-renewable fossil fuel and one of the major contributors of climate change and global warming. We used TANSO FTS instrument in order to obtain the level of atmospheric carbon dioxide through datasets obtained from GOSAT satellite. GIOVANNI was also used to obtain atmospheric concentration of various gases. Burning of coal causes emission of greenhouse gases (GHG) and black carbon (BC) in atmosphere which are responsible for nearly 0.3°C of 1°C rise in temperature. The annual average value of carbon emission for the year 2010 and 2019 is 388.4 ppm and 409 ppm respectively. Since the pre-industrial times CO2 concentrations have increased up to100 PPM (36%) in the last two and a half centuries (250 years).In South Asia Dhaka has the worst quality of air as CO2 concentration (6.7%) is higher than the country’s GDP (5.25%) and energy consumption (4.77%). While an increasing trend GHG has been observed in Lahore up to 5.5 %. This study concludes that the high concentration of carbon dioxide in atmosphere is responsible for average rise of 1.2 °C temperature annually. This temperature rise can lead to adverse climatic conditions i.e., melting of glaciers which will consequently rise the sea level various landmasses may disappear by 2050.
Estimated Zones of Saint-Venant Equations for Flood Routing with Over Bank Unsteady Flow in Open Channel
Authors: Nazir Talat , Awan Sohail Ahmad
Published: October 2022

In this paper, we learn about the control of open channel water glide under the flood routing conditions. Generally, for flood routing in rivers, the Saint-Venant equations will be used which can be solved by finite distinction method. Saint-Venant equations will be converted into nonlinear equations and will be solved using the Preissmann scheme in the finite difference method. Using the Newton Raphson method, the set of equations will be changed into linear equations and will be solved by the space method. Our aims are to the estimated zones of Saint-Venant equations for flood routing by using the finite difference method with over bank unsteady flow in an open channel. The effectiveness of this method to optimize the choice of finite difference method is more accurate than other methods having adequate space and time steps.
Compact Frequency Selective Surface (FSS) for X-Band Shielding
Authors: Khalil Taiba , Riaz Muhammad Ali , Shahid Humayun , Khan Muhammad Jamil , Amin Yasar
Published: October 2022

With the increase in the usage of electromagnetic devices, electromagnetic interference increased many folds. Frequency Selective Surface (FSS) provide effective shielding from unwanted frequency ranges. A thin, conformal band-stop FSS is presented in this research that provides effective electromagnetic shielding properties in X-band. The FSS acts as a band stop filter at 10 GHz. The proposed FSS has 54.7% fractional bandwidth. The design is of the dimensions 6.79 x 6.79 x 0.127 milimeter cube, employing Rogers RT 5880 substrate with 0.0009 dielectric constant. It has an attenuation of at least -57.97 dB. The proposed FSS shows oblique incidence angle independence for both TE and TM modes, up to 60o scan angle. The incidence angle independence makes the FSS response stable for both normal and varying angles of the incident waves. The design has a copper cladding of 0.018 mm, making the overall FSS thickness of 0.145 mm. The thin substrate makes the design flexible and easily bendable for curved surfaces. Its thin structure makes it easily applicable on buildings, vehicles and military aircrafts for electromagnetic shielding purposes. The conformability and shielding properties make the design suitable for various other applications.
Report Generation of Lungs Diseases From Chest X-ray using NLP
Authors: Iftikhar Shagufta , Naz Iqra , Zahra Anmol , Zaidi Syeda zainab Yousuf
Published: October 2022

Pulmonary diseases are very severe health complications in the world that impose a massive worldwide health burden. These diseases comprise of pneumonia, asthma, tuberculosis, Covid-19, cancer, etc. The evidences show that around 65 million people undergo the chronic obstructive pulmonary disease and nearly 3 million people pass away from it each year that make it the third prominent reason of death worldwide. To decrease the burden of lungs diseases timely diagnosis is very essential. Computer-aided diagnostic, are systems that support doctors in the analysis of medical images. This study showcases that Report Generation System has automated the Chest X-Ray interpretation procedure and lessen human effort, consequently helped the people for timely diagnoses of chronic lungs diseases to decrease the death rate. This system provides great relief for people in rural areas where the doctor-to-patient ratio is only 1 doctor per 1300 people. As a result, after utilizing this application, the affected individual can seek further therapy for the ailment they have been diagnosed with. The proposed system is supposed to be used in the distinct architecture of deep learning (Deep Convolution Neural Network), this is fine tuned to CNN-RNN trainable end-to-end architecture. By using the patient-wise official split of the OpenI dataset we have trained a CNN-RNN model with attention. Our model achieved an accuracy of 94%, which is the highest performance.
Statistical Evaluation of Environmental Factors as Diabetogenic Agent in Type 2 Diabetes Mellitus
Authors: shokat saima , Riaz Aasma , Iqbal Dr.Riffat , Yaqub Dr. Atif , Riaz Dr. Samreen
Published: October 2022

The purpose of this study was to analyze the environmental factors affecting individuals with diabetes. A study was conducted among diabetes patients at the Lahore General Hospital's outdoor clinic. Data was collected using a standardized questionnaire after getting approval of patients being interviewed. SPSS 25.0 was utilized for analysis. Total 1000 people were chosen, 500 of whom were diabetic patients and the rest were non-diabetic. Environmental factors were investigated in a 1000-person research of diabetics and non-diabetics. To determine the relationship between patients with diabetes and environmental factors, the Chi-Square test and Mann-Whitney test were used to compare the effects of age, BMI, and sugar level fasting. The findings reveal that environmental factors play crucial effects on patients in term of age, BMI, and sugar level. I also used the odds ratio on diabetic and non-diabetic patients who have the Stroke, TIA, hypertension, and other environmental factors. The study revealed that diabetes is more persistent in industrial and urban region as 60% of the population living in these areas are under risk of diabetes. Moreover, the results showed that nearly 62% tap water consumers in rural areas were diabetic while 38% filtered water consumers in urban areas were diabetic. Smoking caused diabetes in nearly 22% people, 28% people suffered due to utilization of homeopathic medicines while 35% diabetic patients were found multivitamin consumers. Furthermore, the study depicted that among 1000 individuals under study, 56 % females were diabetic due to environmental factors. Diabetes has a direct relationship with the environment experienced by a patient.
Ecological Significance of Floristic Structure and Biological Spectrum of Alpine Floral Biodiversity of Khunjerab National Park Gilgit-Baltistan Pakistan
Authors: Hyder Sujjad , Ibrahim Nasiba
Published: October 2022

The current study was conducted in Khunjerab National Park which is situated in the subalpine zone. The study area was thoroughly surveyed to ensure the maximum collection of flowering plants diversity. The work aimed to investigate the ecological significance of floral structure and the biological spectrum of prevailing flowering plants' biodiversity in the study area. For this purpose, we recognized four ecological zones based on altitude in the park namely the subalpine zone (3000m to 3500m), alpine zone (3600m to 4000m), super alpine zone (4100-4500m), and sub naval zone was started from (4600-4800m) altitude. The collected specimens comprised (155) plant species that belong to 97 genera and 36 families. The life forms of the collected species were 72% Hemicryptophyte (H), 13% Therophytes, 10% Chaemephyte, and 5% Phanerophyte. While the habit categories of the flora were analyzed with the help of Theophrastus classification. The breakup of the habit categories shows that the herbs with 137 species held the highest percentage to contribute the flora of the study area was with 88%, followed by shrubs with 14 species which contributed to the flora of the area was 9.03%. Similarly, subshrubs and trees contained the same number of 2 spices. We observed the phenological status of each species, i.e., flowering and fruiting conditions, and of the species that were infrequent.
Prominence of Filtering Techniques for Harmonics Mitigation in Advanced Power Electronics Systems
Authors: Sadiq Muhammad Arslan , Husain Dr. Nusrat , Shaukat Fawad , Yahya Ashraf , Arfeen Zeeshan Ahmad , Mehboob Osama , Altaf Huzaifa
Published: October 2022

With the advancement in technology, non-linear loads, continue to increase, and the enigma of harmonics is getting more and more serious. The huge addition of electronic loads in power systems has formed the problem of harmonic generation that has resulted in many associated drawbacks. This paper aims to analyze the harmonics in advanced power electronics-based systems and describes a solution to mitigate them through two distinguished filtering techniques. A rigorous analysis is done concerning the generation of harmonic distortion through different types of loads and harmonic mitigation by employing passive and active power filters. The active power (adaptive) filtering method mitigates all sorts of undesirable frequency components using artificial intelligence (AI) based algorithms by calculating the weight of the fundamental component and generating a harmonics replica to subtract it from the original periodic wave. The simulations that were done show that the indicated techniques can mitigate undesirable harmonics and can lower the total harmonic distortion (THD) effectively according to the statutory limit of the IEEE 519-2014 standard, thus lowering the associated drawbacks of harmonic generation in advanced power electronics systems.