bluuebunny/crossref_metadata_2025 huggingface dataset:
Colletes hederae bees are equally attracted by visual and olfactory cues of inconspicuous Hedera helix flowers
Authors: Lukas Kathrin , Dötterl Stefan , Ayasse Manfred , Burger Hannah
Published: September 2023

Wild bees are heavily declining worldwide except for a few species, such as Colletes hederae, which is spreading in its distribution throughout Europe. Colletes hederae mainly forages on ivy (Hedera helix) which is widespread in Europe and the plants’ availability is thought to contribute to the successful spread of C. hederae. A rapid location of the plants using visual and/or olfactory floral cues would allow the bee to efficiently forage. Beside bee visitors, the flowers attract a high variety of other insects, such as Vespula wasps that were recently investigated regarding their floral-cue preferences. The aim of this study was to investigate the communication between C. hederae and its H. helix host flowers, and to compare the results with that previously obtained with V. germanica wasps. We identified headspace compounds detectable by the bees using gas chromatography coupled to electroantennography (GC-EAD) and performed behavioral experiments to both compare the attractiveness of visual and olfactory floral cues and to determine the attractiveness of a synthetic mixture composed of physiologically active compounds. In the GC-EAD analyses, bees responded to 15 flower-specific compounds of various chemical classes, of which 4-oxoisophorone, (E)-linalool-oxide furanoid, and acetophenone were the most abundant in the floral scent. In the bioassays, visual and olfactory flower cues were equally attractive for bees, but a combination of both cues was needed to elicit not only approach responses but also landings. A synthetic mixture of the EAD-active compounds was attractive to the bees, but to a lesser extent than the natural scent of H. helix flowers. The bees’ integrations of different floral-cue modalities in its search image and its strong antennal responses elicited by various floral scent compounds make C. hederae highly effective in finding its host flowers. In comparison to V. germanica wasps, the bees relied stronger on visual cues than the wasps do, but both species showed the highest attraction when presented with a combination of the cues.
Ein geschlechterspezifischer Blick auf das gesundheitsbezogene Informationshandeln, seine Treiber und Barrieren
Authors: Link Elena , Baumann Eva , Aluttis Christoph
Published: September 2023

Hintergrund

Vor dem Hintergrund der Geschlechterperspektive als relevante Ebene effektiver Gesundheitskommunikation wird das gesundheitsbezogene Informationshandeln fokussiert. Ergänzend zur Informationssuche wird die Informationsvermeidung einbezogen. Beide Formen des Informationshandelns werden geschlechterspezifisch beschrieben und sollen anhand verschiedener Ressourcen wie der Gesundheit, dem Wohlbefinden, dem Empowerment, dem Involvement und der sozialen Unterstützung erklärt werden.

Methode

Es wurde eine Online-Befragung einer für die deutsche Bevölkerung stratifizierten Stichprobe (N = 3000) durchgeführt. Erfasst wurden die beiden Formen des Informationshandelns sowie ihre theoretisch abgeleiteten Prädiktoren. Neben deskriptiven Analysen dienen blockweise Regressionsanalysen dazu, geschlechterspezifisch die Prädiktoren der Suche und Vermeidung zu identifizieren.

Ergebnisse

Die Informationssuche findet häufiger statt als die Informationsvermeidung. Beide unterscheiden sich nur in geringem Maß zwischen Männern und Frauen. Für Suche und Vermeidung zeigen sich die stärksten Zusammenhänge mit dem Involvement der Befragten. Für die Suche sind zudem auch Ressourcen des Bedrohungsmanagements bedeutsam, während die Vermeidung mit dem psychischen Wohlbefinden und der sozialen Unterstützung assoziiert ist. Geschlechterübergreifend zeigen sich ähnliche Assoziationsmuster.

Diskussion

Geschlechterübergreifend zeigt sich, dass mittels gesundheitskommunikativer Maßnahmen das Involvement der Bevölkerung unterstützt und Ressourcen des Bedrohungsmanagements gestärkt werden müssen, um die Suche zu fördern und der Vermeidung entgegenzuwirken. Zudem wird deutlich, dass Vermeider*innen als eine zentrale Zielgruppe mehr Aufmerksamkeit erhalten sollten.
Zertifizierung der Deutschen Gesellschaft für Neurorehabilitation e. V., DGNR
Authors: Platz Thomas , Schmidt-Wilcke Tobias , Groß Martin , Friederich Christian , Pohl Marcus
Published: September 2023

Hintergrund

Die Zertifizierung von Zentren für Beatmungsentwöhnung in der neurologisch-neurochirurgischen Frührehabilitation (NNFR) durch die Deutsche Gesellschaft für Neurorehabilitation (DGNR) ist seit dem 01.10.2021 möglich.

Ziel der Arbeit

Die Ergebnisse der Zertifizierung von Einrichtungen im ersten Jahr nach Aufnahme des Verfahrens werden vorgestellt.

Material und Methoden

Im Rahmen der Zertifizierung werden 28 Kriterien geprüft, darunter eine Reihe mandatorisch zu erfüllender Charakteristika der Einrichtung. Die Kriterien gliedern sich in Strukturkriterien (i = 7), Diagnostikkriterien (i = 6), Personalkriterien (i = 3), Kriterien der internen Organisation (i = 7) und Qualitätsmanagementkriterien (i = 5).

Ergebnisse

Insgesamt 13 Zentren wurden im ersten Jahr zertifiziert, die zusammen über 283 Betten zur Beatmungsentwöhnung („weaning“) in der NNFR verfügen und im Jahr vor der Zertifizierung 2278 Personen im Weaning betreuten, im Median pro Einrichtung 134 (Bereich [Min-Max] 44–414). Nur selten war das Weaning nicht erfolgreich, sodass vor Entlassung auf eine Heimbeatmung eingestellt werden musste (invasive Heimbeatmung Median pro Einrichtung 10 Personen, Bereich 2–25; nichtinvasive Heimbeatmung Median 0 Personen, Bereich 0–57). Festgestellt wurde ein hohes Maß an Prozess- und Strukturqualität in den zertifizierten Zentren: Über alle Prüfbereiche hinweg waren die Prüfkriterien zu allermeist erfüllt (Median Erfüllungsgrad 86 %) bzw. erfüllt mit von den Auditor*innen dokumentierten Verbesserungspotenzialhinweisen (Median 11 %).

Schlussfolgerung

Erfolgreiches Weaning in der NNFR und ein hohes Maß an Prozess- und Strukturqualität lassen sich anhand der Zertifizierungsergebnisse der Zentren belegen, die diesen integrativen Ansatz bei der Beatmungsentwöhnung verfolgen.
Grain refinement of aluminium welds by Ti, TiB$$_2$$, and TiC filler wire inoculation
Authors: Kirkbakk Kjell Martin , Marhaug Nikolai , Kvam-Langelandsvik Geir , Werenskiold Jens Christofer
Published: September 2023

A fine-grained fusion zone characterises a tough aluminium weld. To improve the solidification characteristics and refine the grains in aluminium welding, different inoculation particle combinations were introduced to the filler wire by solid state metal screw extrusion. Filler wires were I-joint welded with two different welding methods to reveal the potency for grain refinement. Grain size, microstructure, porosity content, and hardness across the weld was revealed. Gas metal arc welding with a Ti-TiC inoculated filler wire exhibited a remarkable grain refinement of 91% compared to a base reference of commercial pure aluminium. The Al$$_3$$

3

Ti intermetallic phase was found as nucleation point. Gas tungsten arc welding showed lower grain refinement potency, and no Al$$_3$$

3

Ti phase was found in any weld. Thus, the effect of welding method must be taken into consideration upon development of inoculant containing filler wires.
Sex-specific foraging behaviour in a long-lived seabird
Authors: Militão Teresa , Kürten Nathalie , Bouwhuis Sandra
Published: September 2023

Sex-specific foraging behaviour may lead to differences between the sexes in both resource acquisition and exposure to threats and thereby contribute to sex-specific reproductive roles or mortality. As such, it is important to identify in which species sex-specific foraging behaviour occurs. We deployed GPS devices to incubating common terns (Sterna hirundo) from a German breeding population to study how sex and spatial or temporal extrinsic factors influence the daily activity budget, foraging distribution, and trip characteristics of this slightly sexually size dimorphic seabird. Birds of both sexes only foraged during the day, showing peaks of activity after sunrise and before sunset, perhaps in response to temporal variation in prey availability and/or as a strategy to overcome or prepare for nocturnal fasting. Furthermore, foraging was more frequent around low tide and at the beginning of the flood tide and mainly occurred in shallow (< 5 m depth) and coastal waters (< 2 km from coastline) up to 20 km from the colony. Females rested less, foraged closer to the colony in more coastal waters, and showed a lower maximum flight speed than males. Males foraged more outside protected areas than females and showed higher variability in their foraging distribution throughout the tide cycle. As such, our study provides evidence for sex-specific aspects of foraging behaviour in common terns and underlines the importance of considering sex-specific foraging distributions when assessing the impact of at-sea threats on seabirds, knowledge of which should be incorporated when developing conservation management strategies.
Non-big Ulrich bundles: the classification on quadrics and the case of small numerical dimension
Authors: Lopez Angelo Felice , Muñoz Roberto , Sierra José Carlos
Published: September 2023

On any smooth n-dimensional variety we give a pretty precise picture of rank r Ulrich vector bundles with numerical dimension at most $$\frac{n}{2}+r-1$$

n
2

+
r
-
1

. Also, we classify non-big Ulrich vector bundles on quadrics and on the Del Pezzo fourfold of degree 6.
MIL-CELL: a tool for multi-scale simulation of yeast replication and prion transmission
Authors: Hall Damien
Published: September 2023

The single-celled baker’s yeast, Saccharomyces cerevisiae, can sustain a number of amyloid-based prions, the three most prominent examples being [URE3], [PSI+], and [PIN+]. In the laboratory, haploid S. cerevisiae cells of a single mating type can acquire an amyloid prion in one of two ways (i) spontaneous nucleation of the prion within the yeast cell, and (ii) receipt via mother-to-daughter transmission during the cell division cycle. Similarly, prions can be lost due to (i) dissolution of the prion amyloid by its breakage into non-amyloid monomeric units, or (ii) preferential donation/retention of prions between the mother and daughter during cell division. Here we present a computational tool (Monitoring Induction and Loss of prions in Cells; MIL-CELL) for modelling these four general processes using a multiscale approach describing both spatial and kinetic aspects of the yeast life cycle and the amyloid-prion behavior. We describe the workings of the model, assumptions upon which it is based and some interesting simulation results pertaining to the wave-like spread of the epigenetic prion elements through the yeast population. MIL-CELL is provided as a stand-alone GUI executable program for free download with the paper. MIL-CELL is equipped with a relational database allowing all simulated properties to be searched, collated and graphed. Its ability to incorporate variation in heritable properties means MIL-CELL is also capable of simulating loss of the isogenic nature of a cell population over time. The capability to monitor both chronological and reproductive age also makes MIL-CELL potentially useful in studies of cell aging.
Eastern Australian Farmers Managing and Thinking Differently: Innovative Adaptation Cycles
Authors: McKenzie David K. , Joyce Janine , Zander Kerstin K. , Wurm Penelope A. S. , Caudwell Kim M.
Published: September 2023

The uncertainty of climate change is a significant challenge prompting Australian farmers to create different thinking and different management systems that ensure sustained farm business viability and continuity, particularly in extreme environments. The purpose of this study was to explore the conditions and adaptive processes for managing farm resilience and cyclic adaptation pathways, in response to climate change. A positive deviance sample of farmers was interviewed, and data was collected from a cohort of twenty-two climate change innovators across Eastern Australia. Grounded theory analysis of data identified three processes and two transactional maps of climate change adaptation, in this under studied farmer cohort. The development of the transactional maps found the resilience and preparedness processes as adaptive learning responses to the stressors of climate change. The processes of managing the business and resources were identified as markers of preparedness and resilience that ensured business viability and continuity. Farmers prepared for climate change through transforming make-over processes as an adaptive learning response to climate challenges. Mapping the cycle of adaptation identified the processes of socio-cognitive agency, learning from feedback and consequences, and contextual variables as critical elements of adaptation. The intervening socio-ecological processes of intelligence gathering and influencing, and socio-cognitive precursors, were found to regulate the adaptation cycle. The cycle was found to have both incremental and transformative transmission processes, and intervening processes of climate and contextual variables. The changing patterns and extremes of climate change were found to impact the growing season, and its potential, as unique variables that demand farm adaptation. Ultimately, this study identified potential points of influence for leveraging preparedness behaviours.
Risk factors for thromboembolic events in patients with paroxysmal nocturnal hemoglobinuria (PNH): a nested case–control study in the International PNH Registry
Authors: Höchsmann Britta , Peffault de Latour Regis , Hill Anita , Röth Alexander , Devos Timothy , Patriquin Christopher J. , Chou Wen-Chien , Jain Deepak , Zu Ke , Wu Chuntao , Lee Jong Wook
Published: September 2023

The objective of this analysis was to identify risk factors for thromboembolic events (TE) in patients with paroxysmal nocturnal hemoglobinuria (PNH) who were not treated with C5 inhibitors. Patients with PNH and a history of ≥ 1 TE at enrollment in the International PNH Registry (NCT01374360; registration date, January 2011) were each matched with up to 5 patients without TE. Multivariable analysis was performed with the following variables: percentage glycosylphosphatidylinositol (GPI)–negative cells, high disease activity (HDA), non-TE major adverse vascular event history, and recent anticoagulation. Of 2541 eligible patients, 57 with TE and 189 matched controls were analyzed. Multivariable analysis (odds ratio [95% CI]) identified the following factors as being associated with increased thrombotic risk: patients with no history of TE (with recent anticoagulation, 9.30 [1.20–72.27]), patients with history of TE (with recent anticoagulation, 8.91 [0.86–92.62]; without recent anticoagulation, 5.33 [0.26–109.57]), patients with ≥ 30% GPI-negative granulocytes (≥ 30% to < 50%, 4.94 [0.54–45.32]; ≥ 50%, 1.97 [0.45–8.55]), or patients with lactate dehydrogenase (LDH) ratio ≥ 1.5 × upper limit of normal (ULN) plus ≥ 2 HDA criteria (2–3 criteria, 3.18 [0.44–23.20]; ≥ 4 criteria, 3.60 [0.38–33.95]). History of TE, ≥ 30% GPI-negative granulocytes, and LDH ratio ≥ 1.5 × ULN with ≥ 2 HDA criteria are TE risk factors for patients with PNH. These findings will aid physicians by providing important clinical and laboratory risk factors that can be used to identify and manage patients with PNH who are at risk of developing TE.
Distinct smell and taste disorder phenotype of post-acute COVID-19 sequelae
Authors: Rass Verena , Tymoszuk Piotr , Sahanic Sabina , Heim Beatrice , Ausserhofer Dietmar , Lindner Anna , Kofler Mario , Mahlknecht Philipp , Boehm Anna , Hüfner Katharina , Pizzini Alex , Sonnweber Thomas , Kurz Katharina , Pfeifer Bernhard , Kiechl Stefan , Peball Marina , Kindl Philipp , Putnina Lauma , Fava Elena , Djamshidian Atbin , Huber Andreas , Wiedermann Christian J. , Sperner-Unterweger Barbara , Wöll Ewald , Beer Ronny , Schiefecker Alois Josef , Bellmann-Weiler Rosa , Bachler Herbert , Tancevski Ivan , Pfausler Bettina , Piccoliori Giuliano , Seppi Klaus , Weiss Günter , Löffler-Ragg Judith , Helbok Raimund
Published: September 2023

Purpose

Olfactory dysfunction (OD) commonly accompanies coronavirus disease 2019 (COVID-19). We investigated the kinetics of OD resolution following SARS-CoV-2 infection (wild-type and alpha variant) and its impact on quality of life, physical and mental health.

Methods

OD prevalence was assessed in an ambulatory COVID-19 survey (n = 906, ≥ 90 days follow-up) and an observational cohort of ambulatory and hospitalized individuals (n = 108, 360 days follow-up). Co-occurrence of OD with other symptoms and effects on quality of life, physical and mental health were analyzed by multi-dimensional scaling, association rule mining and semi-supervised clustering.

Results

Both in the ambulatory COVID-19 survey study (72%) and the observational ambulatory and hospitalized cohort (41%) self-reported OD was frequent during acute COVID-19. Recovery from self-reported OD was slow (survey: median 28 days, observational cohort: 90 days). By clustering of the survey data, we identified a predominantly young, female, comorbidity-free group of convalescents with persistent OD and taste disorders (median recovery: 90 days) but low frequency of post-acute fatigue, respiratory or neurocognitive symptoms. This smell and taste disorder cluster was characterized by a high rating of physical performance, mental health, and quality of life as compared with convalescents affected by prolonged fatigue or neurocognitive complaints.

Conclusion

Our results underline the heterogeneity of post-acute COVID-19 sequelae calling for tailored management strategies. The persistent smell and taste disorder phenotype is characterized by good clinical, physical, and mental recovery and may pose a minor challenge for public health.

Study registration

ClinicalTrials.gov: NCT04661462 (survey study), NCT04416100 (observational cohort).
Linking connectivity of deep brain stimulation of nucleus accumbens area with clinical depression improvements: a retrospective longitudinal case series
Authors: Leserri Simona , Segura-Amil Alba , Nowacki Andreas , Debove Ines , Petermann Katrin , Schäppi Lea , Preti Maria Giulia , Van De Ville Dimitri , Pollo Claudio , Walther Sebastian , Nguyen T. A. Khoa
Published: September 2023

Treatment-resistant depression is a severe form of major depressive disorder and deep brain stimulation is currently an investigational treatment. The stimulation’s therapeutic effect may be explained through the functional and structural connectivities between the stimulated area and other brain regions, or to depression-associated networks. In this longitudinal, retrospective study, four female patients with treatment-resistant depression were implanted for stimulation in the nucleus accumbens area at our center. We analyzed the structural and functional connectivity of the stimulation area: the structural connectivity was investigated with probabilistic tractography; the functional connectivity was estimated by combining patient-specific stimulation volumes and a normative functional connectome. These structural and functional connectivity profiles were then related to four clinical outcome scores. At 1-year follow-up, the remission rate was 66%. We observed a consistent structural connectivity to Brodmann area 25 in the patient with the longest remission phase. The functional connectivity analysis resulted in patient-specific R-maps describing brain areas significantly correlated with symptom improvement in this patient, notably the prefrontal cortex. But the connectivity analysis was mixed across patients, calling for confirmation in a larger cohort and over longer time periods.
Healthcare utilization prior to a diagnosis of young-onset Alzheimer’s disease: a nationwide nested case–control study
Authors: Damsgaard Line , Janbek Janet , Laursen Thomas Munk , Waldemar Gunhild , Jensen-Dahm Christina
Published: September 2023

Objective

Our aim was to identify changes in healthcare utilization prior to a young-onset Alzheimer’s disease diagnosis.

Methods

In a retrospective incidence density matched nested case–control study using national health registers, we examined healthcare utilization for those diagnosed with young-onset Alzheimer’s disease in Danish memory clinics during 2016–2018 compared with age- and sex-matched controls. Negative binomial regression analysis produced contact rate ratios.

Results

The study included 1082 young-onset Alzheimer’s disease patients and 3246 controls. In the year preceding diagnosis, we found increased contact rate ratios for all types of contacts except physiotherapy. Contact rate ratios for contacts with a general practitioner were significantly increased also > 1–5 and > 5–10 years before diagnosis. The highest contact rate ratios were for psychiatric emergency contacts (8.69, 95% CI 4.29–17.62) ≤ 1 year before diagnosis.

Interpretation

Results demonstrate that young-onset Alzheimer’s disease patients have increased healthcare utilization from 5 to 10 years prior to diagnosis. Awareness of specific alterations in health-seeking behaviour may help healthcare professionals provide timely diagnoses.
Mesonephric-like adenocarcinoma of the female genital tract: possible role of KRAS-targeted treatment—detailed molecular analysis of a case series and review of the literature for targetable somatic KRAS-mutations
Authors: Brambs Christine E. , Horn Lars-Christian , Hiller Ruth , Krücken Irene , Braun Christian , Christmann Corina , Monecke Astrid , Höhn Anne Kathrin
Published: September 2023

Purpose

Mesonephric-like adenocarcinomas (MLA) of the female genital tract represent a rare and relatively recently described neoplasm exhibiting characteristic morphologic and immunohistochemical findings commonly associated with a KRAS-mutation. Most cases display an aggressive clinical behavior, but knowledge about treatment approaches is limited, especially for targeting KRAS.

Methods

We report a series of eight cases with a detailed molecular analysis for KRAS. These cases as well as the data of previously published cases with detailed information regarding KRAS-mutational events were reviewed for a potential targeted approach and its prognostic impact.

Results

Both the uterine and ovarian MLA harbor a somatic KRAS-mutation in about 85% of the reported cases, affecting the hotspot codons 12 and 13. 15.7% of the endometrial and 15.6% of ovarian MLA are wild type for KRAS. A p.G12A-alteration was seen in 5.6% (5/89) of the endometrial and in 6.2% (2/32) of the ovarian tumors, for p.G12C in 7.9% and 6.2%, for p.G12D in 32.6% and 34.5% and for p.G12V in 36% and 37.5%, respectively. Very limited data are available regarding the prognostic impact of different mutational sites within the KRAS-gene without significant prognostic impact.

Conclusion

Because of a specific p.G12C-KRAS somatic mutation, only the minority of MLA (7.9% with uterine and 6.2% with ovarian primary) are potentially targetable by sotarasib in that rare but aggressive subtype of adenocarcinoma of the female genital tract. Until now, the different location of a somatic KRAS-mutation is of no prognostic impact.
A proposed framework for advancing acute kidney injury risk stratification and diagnosis in children: a report from the 26th Acute Disease Quality Initiative (ADQI) conference
Authors: Fuhrman Dana Y. , Stanski Natalja L. , Krawczeski Catherine D. , Greenberg Jason H. , Arikan A. Ayse Akcan , Basu Raj K. , Goldstein Stuart L. , Gist Katja M. ,   the ADQI 26 workgroup, Alobaidi Rashid , Askenazi David J. , Bagshaw Sean M. , Barhight Matthew , Barreto Erin , Bayrakci Benan , Ray Bignall O. N. , Bjornstad Erica , Brophy Patrick , Charlton Jennifer , Chanchlani Rahul , Conroy Andrea L. , Deep Akash , Devarajan Prasad , Dolan Kristin , Fuhrman Dana , Gist Katja M. , Gorga Stephen M. , Greenberg Jason H. , Hasson Denise , Heydari Emma , Iyengar Arpana , Jetton Jennifer , Krawczeski Catherine , Meigs Leslie , Menon Shina , Morgan Catherine , Morgan Jolyn , Mottes Theresa , Neumayr Tara , Ricci Zaccaria , Selewski David T. , Soranno Danielle , Stanski Natalja , Starr Michelle , Sutherland Scott M. , Symons Jordan , Tavares Marcelo , Vega Molly , Zappitelli Michael , Ronco Claudio , Mehta Ravindra L. , Kellum John , Ostermann Marlies
Published: September 2023

Acute kidney injury (AKI) in children is associated with increased morbidity, reduced health-related quality of life, greater resource utilization, and higher mortality. Improvements in the timeliness and precision of AKI diagnosis in children are needed. In this report, we highlight existing, novel, and on-the-horizon diagnostic and risk-stratification tools for pediatric AKI, and outline opportunities for integration into clinical practice. We also summarize pediatric-specific high-risk diagnoses and exposures for AKI, as well as the potential role of real-time risk stratification and clinical decision support to improve outcomes. Lastly, the key characteristics of important pediatric AKI phenotypes will be outlined. Throughout, we identify key knowledge gaps, which represent prioritized areas of focus for future research that will facilitate a comprehensive, timely and personalized approach to pediatric AKI diagnosis and management.
Factors associated with suicide attempt risk in adolescent inpatient psychiatric care: toward a practical model
Authors: Szmajda Rafał , Mokros Łukasz , Szmajda-Krygier Dagmara , Gmitrowicz Agnieszka
Published: September 2023

Suicide is an important social and medical problem, particularly among children and adolescents. The aim of the study was to determine the association of the psychiatric diagnosis and selected psychosocial factors with the risk of suicide attempts among patients of an adolescent psychiatric unit. A retrospective analysis was performed on a database of consecutive N = 1311 patients aged 13–18 years of the adolescent psychiatric ward. A hierarchical logistic regression analysis was performed to assess the predictive value of the main psychiatric diagnosis, for factors selected from the database to determine their influence on the relative risk of a suicide attempt. Primary diagnoses of mood disorders and emotional and behavioral disorders were associated with an increased risk of a current admission after a suicidal attempt, a history of past suicidal attempts and non-suicidal self-harm (NSSI). History of NSSI was associated with a fourfold increase probability of a suicide attempt. Truancy, sexual abuse, heartbreak and frequent conflicts were related to a rise in suicidal attempt risk. Learning difficulties were found to be linked to increased probability of suicidal attempt, but only among women. The current study confirms that the primary diagnosis, NSSI and well-recognized psychosocial factors (including family- and school-related factors) may prove useful in the assessment of suicidal risk among adolescents admitted to a psychiatric ward.
Experimental investigation of moving contact pattern in helical planetary gearboxes
Authors: Fürst Marius , Sepp Sebastian , Schweigert Daniel , Otto Michael , Stahl Karsten
Published: September 2023

Planetary gear sets combine the characteristics of high-power density and compact design which are beneficial for a wide range of high-performance applications. Embedded in the efforts for resource efficiency and cost reduction, new challenges arise regarding a lightweight design. An accurate prediction of the load sharing on the individual planetary gears and especially of the load distribution of the meshing gears is of major importance. A uniform load distribution enables the design of the individual tooth meshes without load increases and oversizing. However, a varying load distribution has been observed in planetary gearboxes with respect to the rotation of the carrier which is caused by misaligned central shafts of the gearbox. This behavior is influenced by several factors, such as manufacturing and assembly deviations, the rigidity of shafts, housing and bearings, the number of planets, the quality of the gear wheels and the operating conditions. To determine the exact load distribution, detailed simulations or extensive experimental prototype tests are required. In an early design phase, these detailed boundary conditions are not yet defined and their effect on a moving contact pattern therefore cannot be reliably considered.

Thus, in this paper an experimental investigation of the influencing factors on a varying load distribution with regard to the carrier rotation is presented. Based on experimental data recommendations for the design of planetary gearboxes are derived.
Simulation extractable versions of Groth’s zk-SNARK revisited
Authors: Amine Oussama , Baghery Karim , Pindado Zaira , Ràfols Carla
Published: September 2023

Zero-knowledge succinct non-interactive arguments of knowledge (zk-SNARKs) are the most efficient proof systems in terms of proof size and verification. Currently, Groth’s scheme from EUROCRYPT 2016, $$\textsf{Groth16}$$

Groth
16

, is the state-of-the-art and is widely deployed in practice. $$\textsf{Groth16}$$

Groth
16

is originally proven to achieve knowledge soundness, which does not guarantee the non-malleability of proofs. There has been considerable progress in presenting new zk-SNARKs or modifying $$\textsf{Groth16}$$

Groth
16

to efficiently achieve strong Simulation extractability, which is shown to be a necessary requirement in some applications. In this paper, we revise the Random oracle based variant of $$\textsf{Groth16}$$

Groth
16

proposed by Bowe and Gabizon, BG18, the most efficient one in terms of prover efficiency and CRS size among the candidates, and present a more efficient variant that saves 2 pairings in the verification and 1 group element in the proof. This supersedes our preliminary construction, presented in CANS 2020 (Baghery et al. in CANS 20, volume 12579 of LNCS, Springer, Heidelberg. pp 453-461, 2020), which saved 1 pairing in the verification, and was proven in the generic group model. Our new construction also improves on BG18 in that our proofs are in the algebraic group model with Random Oracles and reduces security to standard computational assumptions in bilinear groups (as opposed to using the full power of the generic group model (GGM)). We implement our proposed simulation extractable zk-SNARK (SE zk-SNARK) along with BG18 in the library, and compare the efficiency of our scheme with some related works. Our empirical experiences confirm that our SE zk-SNARK is more efficient than all previous simulation extractable (SE) schemes in most dimensions and it has very close efficiency to the original $$\textsf{Groth16}$$

Groth
16

.
Clinical and immunological characterisation of patients with common variable immunodeficiency related immune thrombocytopenia
Authors: Somasundaram Nadia , Meyer Oliver , Scheibenbogen Carmen , Hanitsch Leif Gunnar , Stittrich Anna , Kölsch Uwe , Wittke Kirsten
Published: September 2023

Primary Immune thrombocytopenia (ITP) is an autoimmune disease. Secondary ITP occurs in patients with underlying diseases such as common variable immunodeficiency (CVID). CVID is one of the most common symptomatic primary immunodeficiencies in adults, characterised by infectious and non-infectious symptoms. Amongst CVID patients, ITP is the most frequent autoimmune manifestation. In this single-centre study, we performed a clinical and immunological characterisation of 20 patients with CVID-related ITP and 20 ITP patients without CVID to compare severity and remission rates. We found that patients with CVID-related ITP had a higher WHO Bleeding Scale at initial diagnosis yet showed higher remission rates and required less treatment. Patients with ITP needed up to seven therapy options and were often treated with second-line drug therapy, whilst only one CVID-related ITP patient required second-line drug therapy. Therefore, we show that the course of thrombocytopenia in patients with CVID-related ITP is milder. Furthermore, we show that soluble interleukin-2 receptor (sIL-2R, CD25) was higher in CVID-related ITP compared to ITP patients and could accurately classify patient cohorts with an Area Under the Receiver Operating Characteristic of 0.92. Whilst none of the ITP patients had a history of immunodeficiency, we found immunological abnormalities in 12 out of 18 patients. Therefore, we recommend screening ITP patients for CVID and other immunodeficiencies to detect immune abnormalities early, as we found patients with reduced immunoglobulin levels as well as severe lymphocytopenia in our ITP cohort.
Iterative threshold-based Naïve bayes classifier
Authors: Romano Maurizio , Zammarchi Gianpaolo , Conversano Claudio
Published: September 2023

The iterative Threshold-based Naïve Bayes (iTb-NB) classifier is introduced as a (simple) improved version of the previously introduced non-iterative Threshold-based Naïve Bayes (Tb-NB) classifier. iTb-NB starts from a Natural Language text-corpus and allows the user to quantify with a numeric value a sentiment (positive or negative) from a specific test. Differently from Tb-NB, iTb-NB is an algorithm aimed at estimating multiple threshold values that concur to refine Tb-NB’s decision rules when classifying a text into positive (negative) based on its content. Observations with sentiment scores close to the threshold are marked to be reclassified, hence a new decision rule is defined for them. Such “iterative” process improves the quality of predictions w.r.t. Tb-NB but keeping the possibility to utilize its results as the input of useful post-hoc analyses. The effectiveness of iTb-NB is evaluated analyzing hotel guests’ reviews from all hotels located in the Sardinia region and available on Booking.com. Furthermore, iTb-NB is compared with Tb-NB in terms of model accuracy, resistance to noise, and computational efficiency.
Biotechnology activism is dead; long live biotechnology activism! The lure and legacy of market-based food movement strategies
Authors: Pechlaner Gabriela
Published: September 2023

Scholarly debate over the transformative potential of neoliberal, market-based, food movement strategies historically contrasts those who value their potential to reform the food-system from the inside against those who argue that their use concedes the primacy of the market, creates citizen-consumers, and undermines overall movement goals. While narrow case studies have provided important amendments, the legacy of such strategies requires impacts to be evaluated both contextually and more broadly than the specific activism. This study thus conceptualizes the ‘case’ of U.S. biotechnology market activism expansively, drawing on interviews with 25 activists from diverse organizations to investigate the legacy of two food-labeling movement strategies (one public and mandatory, one private and voluntary). The results support that the legacy of market strategies extends more broadly than the immediate initiative. They also confirm that the consequences of such neoliberalized strategies are most productively assessed contextually and applied, rather than categorically—as most clearly illustrated by the counterintuitive results of the failed mandatory labeling effort. Of the two market strategies, voluntary labeling demonstrated the most problematic relationship to broader movement goals of food system transformation, in part because of the greater potential for overlapping credence claims and in part due to the risks of niche market logic.
Modulation of Turbulence Flux Budgets by Varying Fluid Properties in Heated High Prandtl Number Flow
Authors: Irrenfried Christoph , Steiner Helfried
Published: September 2023

The accurate computational modelling of momentum and heat transfer in turbulent wall-bounded flow is still a challenging task, especially for fluids with high molecular Prandtl numbers. Due to the steep temperature gradients, the strong variation of fluid properties becomes an additional important issue. The present Direct Numerical Simulation study specially addresses this problem considering a representative working fluid in terms of a real heat transfer oil with temperature-dependent material properties. Near the heated wall, the increase in molecular viscosity significantly attenuates the turbulent convective fluxes of both momentum and heat, despite the markedly increased enthalpy fluctuations. As the thermal conductivity decreases markedly less with temperature than the viscosity, the dampened turbulent mixing significantly reduces the Nusselt number, whereas the skin friction coefficient only marginally differs from the constant fluid property case. The attenuation of the radial velocity fluctuation consistently reduces the production terms in the budgets of the turbulent momentum and heat fluxes, while the production of the enthalpy fluctuations is only shifted away from the wall without significant change in peak level. The also attenuated redistribution in the turbulent axial stress budget reduces the pressure-strain based steering of turbulence towards isotropy. Facing a consequently more anisotropic turbulent motion poses a further difficulty to standard turbulence modelling mostly developed for isotropic turbulence.
Slip and Twinning in Bravais Lattices
Authors: Ball John M.
Published: September 2023

A unified treatment of slip and twinning in Bravais lattices is given, focussing on the case of cubic symmetry, and using the Ericksen energy well formulation, so that interfaces correspond to rank-one connections between the infinitely many crystallographically equivalent energy wells. Twins are defined to be such rank-one connections involving a nontrivial reflection of the lattice across some plane. The slips and twins minimizing shear magnitude for cubic lattices are rigorously calculated, and the conjugates of these and other slips analyzed. It is observed that all rank-one connections between the energy wells for the dual of a Bravais lattice can be obtained explicitly from those for the original lattice, so that in particular the rank-one connections for fcc can be obtained explicitly from those for bcc.
Geochemical evolution of dissolved trace elements in space and time in the Ramganga River, India
Authors: Sen Indra Sekhar , Nizam Sarwar , Ansari Aqib , Bowes Michael , Choudhary Bharat , Glendell Miriam , Ray Surajit , Scott Marian , Miller Claire , Wilkie Craig , Sinha Rajiv
Published: September 2023

Understanding the spatiotemporal dynamics of river water chemistry from its source to sinks is critical for constraining the origin, transformation, and “hotspots” of contaminants in a river basin. To provide new spatiotemporal constraints on river chemistry, dissolved trace element concentrations were measured at 17 targeted locations across the Ramganga River catchment. River water samples were collected across three seasons: pre-monsoon, monsoon, and post-monsoon between 2019 and 2021. To remove the dependency of trace element concentrations on discharge, we used molar ratios, as discharge data on Indian transboundary rivers are not publicly available. The dataset reveals significant spatiotemporal variability in dissolved trace element concentrations of the Ramganga River. Samples collected upstream of Moradabad, a major industrial city in western Uttar Pradesh, are characterized by ~ 1.2–2.5 times higher average concentrations of most of the trace elements except Sc, V, Cr, Rb, and Pb, likely due to intense water–rock interactions in the headwaters. Such kind of enrichment in trace metal concentrations was also observed at sites downstream of large cities and industrial centers. However, such enrichment was not enough to bring a major change in the River Ganga chemistry, as the signals got diluted downstream of the Ramganga-Ganga confluence. The average river water composition of the Ramganga River was comparable to worldwide river water composition, albeit a few sites were characterized by very high concentrations of dissolved trace elements. Finally, we provide an outlook that calls for an assessment of stable non-traditional isotopes that are ideally suited to track the origin and transformation of elements such as Li, Mg, Ca, Ti, V, Cr, Fe, Ni, Cu, Zn, Sr, Ag, Cd, Sn, Pt, and Hg in Indian rivers.
A decomposition and decoupling analysis for carbon dioxide emissions: evidence from OECD countries
Authors: Magazzino Cosimo , Pakrooh Parisa , Abedin Mohammad Zoynul
Published: September 2023

Despite the huge difference in their climatic regimes, the OECD countries are among the world’s largest energy consumers and emitters of greenhouse gases, particularly carbon dioxide. Nonetheless, no studies have been conducted to decompose and decouple the long-term influential primary factors of carbon emissions for these countries. In this research, the Log Mean Divisia Method I is used to inspect the contribution of several influencing factors to fill this knowledge gap. Moreover, Tapio (Transp Policy 12(2):137–151, 2005) decomposition analysis (DA) is performed to investigate the driving forces of CO2 emissions over the 1990–2019 years. The study provides an in-depth analysis of how to reduce CO2 emissions and the factors that contribute to their variation, which is crucial for both global and regional climate change policies. DA shows that, up to 2004, the activity effect and the population effect drove the emissions to increase; while, in more recent years, the activity effect was able to curb the emissions. Decoupling analysis show the prevalence of the expansive negative decoupling regime for the 1990–2004 and 2015–2019 periods, while several countries were in the strong decoupling phase over the central period (2005–2009). According to the results, further efforts to increase energy efficiency, political support for digitalization and decentralized energy systems, and setting up a unique emission trading system are recommended for air pollution reduction.
Heidegger’s Worldview – Freedom, Control and Affectivity
Authors: Lepis Beatrix Susanne
Published: September 2023

The tendency of individuals to protect their own worldview by rejecting information and phenomena that cannot be reconciled with it is a significant issue in today’s polarised society. This paper aims to gain a deeper insight into this tendency towards exclusion and the impact it has on worldview by examining a particular interpretation of worldview developed in the late 1930s by Martin Heidegger. It is a radical account that portrays a highly restrictive and extremely closed-off model of worldview, within which exclusion plays a key role. The impact of this exclusion on the nature and shape of worldview is explored by analysing worldview from three distinct perspectives focusing on (1) its appearance, marked by freedom and safety, (2) its inner dynamic, marked by absolute control, and (3) its affective background, marked by frantic struggle and dread. The analysis reveals a dread-fuelled, highly reactionary, and thus extremely fragile structure that is fundamentally shaped by the endless effort to conceal the exclusion on which it is built, resulting in a complete inability to engage with that which is excluded without severely endangering the very existence of that worldview.
Identification of Biodegradable, Compostable or Toxic Plastic Bags with Two Beetles of the Tenebrionidae Family
Authors: Huidobro Medina Erik Saul , Rojas-Valencia María Neftalí , Fernández-Rojas Denise Yeazul , Araiza-Aguilar Juan Antonio
Published: September 2023

Various studies have demonstrated the environmental problems caused by plastic bags (PB) made with hydrocarbons, and therefore international policies have been established to replace the use of conventional PB by biobags or compostable bags, which are designed to be biodegradable and/or composted in the environment. However, the methods used to characterize such bags are still far from being effectively assessed. This study evaluated a technique to identify biodegradable, compostable and/or toxic PB by feeding compostable bags certified by recognized institutions to larvae of theTenebrionidaefamily, particularlyTenebrio molitorandZophobas moriospecies. Three brands of single-use bags were studied, and the following parameters were evaluated: rate of consumption (of bags by larvae), percentage of biomass (weight increase in larvae), percentage of survival (percentage of larvae eating bags), percentage of biodegradability by evaluating the total organic carbon (TOC) in stool, and stool analysis by spectroscopy and spectrometry. The results showed differences between the rate of consumption, the EHappy bag being the most consumed; there were differences in the percentage of biomass, the EHappy bag showing less potential for biomass increase; both species showed lower survival with the Ealternative bag. TOC evaluation indicated that the WCare bag presents the highest biodegradability; the total reflectance attenuated infrared analysis showed a decrease in the representative peaks of the spectrum of PB, evidencing biodegradation; and the amount of metals in feces was found within the Maximum Permissible Limits. The two species showed a good performance, demonstrating that they can be used as a suitable and viable tool to evaluate toxicity, biodegradability and compostability.
Comparing the Symptomatology of Post-stroke Depression with Depression in the General Population: A Systematic Review
Authors: Blake J. J. , Gracey F. , Whitmore S. , Broomfield N. M.
Published: September 2023

Previous research into the phenomenological differences of post-stroke depression (PSD) has typically focused on comparisons of symptom profiles between stroke and non-stroke population controls. This systematic review aimed to synthesize these findings with results from other methodological approaches that contribute to an understanding of phenomenological differences. Articles were identified via a systematic search of seven databases and additional manual searching. A narrative synthesis approach was adopted because of the high methodological heterogeneity. Twelve articles comparing the symptomatology of depression between stroke and non-stroke controls were included. Three distinct methodological approaches, relevant to the aim, were identified: comparisons of profiles among groups with similar overall depression severity, comparisons of the strengths of correlations between a symptom and depression, and comparisons of latent symptom severity. The symptomatology of depression was generally similar between the groups, including somatic symptoms, despite the hypothesized interference of comorbid physical stroke effects. Despite high heterogeneity, there was a tentative indication that post-stroke depression manifests with comparatively less severe/prevalent anhedonia. Possible mechanisms for the observed similarities and differences are explored, including suggestions for future research.