bluuebunny/crossref_metadata_2025 huggingface dataset:
Unknown ground moving target tracking using multiple unmanned aerial vehicles
Authors: He Shaoming , Wang Jiang , Lin Defu
Published: December 2017

This paper investigates the problem of robust guidance law design for multiple unmanned aerial vehicles to achieve desired formation pattern for standoff tracking of an unknown ground moving target. The proposed guidance law consists of two main parts: relative range regulation and space angle control. For the first mission, a novel control law is proposed to regulate the relative distance between the unmanned aerial vehicle and the ground moving target to zero asymptotically based on adaptive sliding mode control approach. Considering the discontinuous property of the sign function, which is often used in traditional sliding mode control and will result in high-frequency chattering in the control channel, the proposed controller adopts the continuous saturation function for chattering elimination. Besides the continuous property, convergence to the origin asymptotically can be guaranteed theoretically with the proposed controller, which is quite different from traditional boundary layer technique, where only bounded motion around the sliding manifold can be ensured. For asymptotic stability, it is only required that the lumped uncertainty is bounded, but the upper bound may be unknown by virtue of the designed adaptive methodology. For space angle control, a new multiple leader–follower information architecture is introduced and an acceleration command is then derived for each unmanned aerial vehicle to space them about the loiter circle defined by the first controller. Simulation results with different conditions clearly demonstrate the superiority of the proposed formulation.
Numerical simulation of coupled thermal-mechanical fracturing in underground coal gasification
Authors: Duan Tian-Hong , Zhang Jian-Ming , Mallett Cliff , Li Hong-Hang , Huo Li-Wen , Zhao Kai-Ting
Published: December 2017

A combination of thermal fracturing and stress-induced fracturing, i.e. coupled thermal-mechanical fracturing, occurs under the effect of combustion-generated heat and stress in underground coal gasification. Controlling the cracking of roofs and floors and the precise positioning of the combustion zone in underground coal gasification requires full knowledge of the characteristics of the coupled thermal-mechanical fracturing of the surrounding rocks. This study considers the variation in the physical and mechanical parameters of the rock with temperature and rock heterogeneity in order to derive a mathematical model of coupled thermal-mechanical fracturing. Then, a numerical simulation is performed, from which the following conclusions can be reached. First, temperature increases expand fractures, which emerge in the highest temperature area, before extending to lower temperature areas. Second, fracture density is directly related to temperature, with higher temperature corresponding to greater fracture density. Third, the cracking rate increases linearly with time in stages. For m = 1, the growth rate of the cracking rate are 55.76%/h, 26.08%/h correspondingly during the first stage (from 0.8 h to 1.6 h) and the second stage (from 1.6 h to 2 h).While for m = 2, the growth rates are 18.50%/h, 40.99%/h correspondingly during the first stage (from 0.8 h to 1.3 h) and the second stage (from 1.3 h to 2 h). Finally, fracture formation speed is slower in more homogeneous conditions when other conditions are unchanged. A few fractures emerge in the sample after 1.3 h for m = 2; the sample cracking rate is only 14.84%, which is far lower than for m = 1 at the same time (32.31%). Similarly, the cracking rate reaches 29.94% after 1.6 h for m = 2 (still far lower than that for m = 1 at the same time, which is 46.91%). The average growth rate of cracking rate for m = 1 (27.16%/h) is quicker than that of m = 2(21.77%/h).
Performance measurement and its impact on Brazilian public academic libraries
Authors: Celere Milena , Mendes Glauco Henrique de Sousa , Ganga Gilberto Miller Devós , Martins Roberto Antonio
Published: December 2017

Assessment and measurement of performance in academic libraries are well established. However, in developing countries such as Brazil, this has not been fully explored. This study aims to contribute to the knowledge by investigating practices of measuring library performance in Brazilian public academic libraries and analyzing their relationship with managerial processes. It employs a survey method with a descriptive-explanatory objective and follows a quantitative research approach. Data was gathered from 149 libraries. Results indicate that performance measurement system at academic libraries in Brazil lack systematic methods. However, libraries with implemented performance management systems have better management practices, reflecting in their library management maturity.
Exploring School Nurse Interventions and Health and Education Outcomes: An Integrative Review
Authors: Best Nakia C. , Oppewal Sonda , Travers Debbie
Published: December 2017

School nurses intervene with students, parents, and school staff to advance the health and academic success of students. We conducted an integrative literature review of published research to describe the types of school nurse interventions and health and education outcome measures and to examine how school nurse interventions were linked to student outcomes. Sixty-five studies met the inclusion criteria. We used the National Association of School Nurses’ Framework for 21st Century School Nursing Practice to categorize school nurse interventions and health and education outcome measures. The majority of interventions were categorized under the care coordination principle, most commonly, motivational interviewing and counseling. In 17 studies, school nurse interventions were linked to improved student outcomes. Most studies (80%) were descriptive. To advance school nursing science, researchers can build on this foundation with more rigorous research methods to evaluate the impact of school nurse interventions and activities on student health and education outcomes.
Primary Carcinosarcoma of the Vagina Associated With Differentiated Squamous Intraepithelial Neoplasia in a Patient With Complete Uterine Prolapse: Case Report and Review of the Literature
Authors: Babarović Emina , Sladoljev Karla , Perin Ena , Klarić Marko , Karnjuš-Begonja Ružica , Sinožić Tamara , Dinter Morana , Gačanin Lana Glavan , Eminović Senija
Published: December 2017

Vaginal carcinosarcomas (VCSs) are rare and clinically aggressive neoplasms. Primary vaginal malignancies are among the rarest malignant tumors, so clear management guidelines and optimal therapy, especially in the presence of significant pelvic organ prolapse, has not been determined. Here, we present a case of primary VCS closely associated with differentiated squamous intraepithelial neoplasia (DSIN), from which it appeared to have arisen in a postmenopausal patient with complete uterine prolapse. The unusual presentation of our case with DSIN in the adjacent vaginal epithelium with possible diagnostic pitfalls emphasizes the need for systemic presentation of these cases to help pathologists and clinicians know that such lesions can initially present in a patient with complete uterine prolapse. To our knowledge, this is the first case of vaginal DSIN described in the literature to date.
Graft-Versus-Host Disease With Early Cytomegalovirus Infection in Gastrointestinal Tract Biopsies
Authors: Sun Belinda L. , Jain Richa , Patel Charmi , Bhattacharyya Achyut K.
Published: December 2017

Gastrointestinal (GI) graft-versus-host disease (GVHD) and cytomegalovirus (CMV) infection often simulate each other. However, distinction between GVHD and CMV infection is critical in the management of immunosuppression for transplant recipients. This study retrospectively reviewed 16 patients diagnosed with GVHD from 2010 to 2016 and found 4 cases (25%) coinfected with CMV. Two cases were initially diagnosed as GVHD only but found to have CMV infection by serological testing within 3 days after immunosuppression treatment for GVHD. The remarkable histological feature of CMV infection appeared to be significant acute inflammation in addition to apoptotic epithelial injuries, and particularly in an early stage of CMV replication, acute inflammation is possibly the only detectable feature of CMV infection.
Incidence of skeletal related events in patients with bone metastasis receiving denosumab every four weeks compared to intervals greater than every four weeks
Authors: Yerram Prakirthi , Moore Russell , Wolf Steven , Barbour Sally Y
Published: December 2017

Objective

Denosumab is a monoclonal antibody used for prevention of skeletal related events in patients with bone metastasis from solid tumors and is administered every four weeks. In our practice, denosumab is often given at different frequencies more similar to patient’s chemotherapy regimens to decrease frequency of clinic visits. The purpose of this study is to compare the incidence of skeletal related events, incidence of hypocalcemia, and cost with denosumab given at every four weeks and denosumab given at other frequencies.

Methods

This retrospective study at Duke University Health System included solid tumor patients with an age ≥18 years who received denosumab for prevention of skeletal related events.

Results

A total of 94 patients were included, with 29 in the every four-week group and 65 in the greater than every four-week group. Patients who received denosumab every four weeks had a 41.4% incidence of skeletal related events compared to 26.2% incidence of skeletal related events in patients who received denosumab at intervals greater than every four weeks (OR: 0.50; p = 0.14). There was no statistically significant difference in incidence of hypocalcemia. Based on average wholesale price, when the frequency of denosumab is extended to greater than every four weeks, annual cost savings per patient ranged from $4700 (every 5 weeks) to $18,800 (every 12 weeks).

Conclusion

While this study raises the possibility of decreasing the frequency of denosumab administration, further data are necessary to confirm that less frequent administration is non-inferior to every four-week administration.
A retrospective analysis of clinical acuity markers on hospital length of stay in patients with febrile neutropenia
Authors: Johannesmeyer Herman J , Seifert Charles F
Published: December 2017

Objective

The primary objective of this study was to identify factors that have predictive value in determining total hospital length of stay in patients with febrile neutropenia, particularly time to first antibiotic dose.

Methods

This study was a retrospective chart review analyzing patients admitted to a 443 bed tertiary county teaching hospital from 1 November 2010 through 1 November 2015. Patients were eligible for enrollment into the study if they met Infectious Diseases Society of America accepted criteria for febrile neutropenia.

Results

Ninety-three patients were included for analysis. Time to first antibiotic dose, first empirically appropriate antibiotic dose, and time to first isolate-appropriate antibiotic did not show a significant correlation to total hospital length of stay (p = 0.71, p = 0.342, and p = 0.77, respectively). Subject’s Multinational Association for Supportive Care in Cancer and Simplified Acute Physiology II scores were significantly correlated with hospital lengths of stay (p = 0.0052, rs = −0.243 and p = 0.0001, rs = 0.344, respectively). Higher median (interquartile ranges) Simplified Acute Physiology II scores were also associated with hospital mortality [dead = 46 (34.8–51.7) vs. alive = 34 (28–43.3), p = 0.0173].

Conclusions

Measures of patient acuity, such as the Multinational Association for Supportive Care in Cancer and Simplified Acute Physiology II scores, did show a correlation to clinical outcomes in patients with febrile neutropenia. Timing of initial antibiotics between 2.32 and 6.27 hours after presentation in patients with febrile neutropenia did not correlate with clinical outcomes.
Cardiac birth defects in a twin infant born to a woman with chronic myeloid leukemia on dasatinib
Authors: Hermel David J , Chiu Victor , Hermel Melody H , Tulpule Anil , Akhtari Mojtaba
Published: December 2017

Preclinical animal studies have demonstrated an association between maternal use of tyrosine kinase inhibitors and embryofetal toxicity; yet, multiple clinical case series have reported normal pregnancy outcomes and healthy infants in women on these medications during the course of their pregnancy. We describe a case of a woman with chronic myeloid leukemia who had taken the second-generation tyrosine kinase inhibitor dasatinib during the first 12 weeks of her dichorionic diamniotic twin pregnancy and subsequently delivered two low-birth weight infants, one with severe cardiac malformations and the other without apparent birth abnormalities. To our knowledge, this is the first reported case of fetal cardiovascular defects in an infant born to a woman on dasatinib during a twin pregnancy and supports current recommendations to avoid this medication during pregnancy. We also review relevant preclinical and clinical studies of tyrosine kinase inhibitor use during pregnancy and explore alternative therapeutic options for patients with chronic myeloid leukemia during pregnancy to aid clinicians in the appropriate management of these patients so as to minimize both maternal and fetal risks.
Guided wave propagation in functionally graded cylindrical structures with sector cross-sections
Authors: Bo Zhang , Jiangong Yu , Lefebvre Jean-Etienne , Weijiang Xu , Xiaoming Zhang , Pingmei Ming
Published: December 2017

The differential equations governing guided waves in functionally graded cylindrical structures with sector cross-sections are solved by introducing the double orthogonal polynomial series method into the cylindrical coordinate system, and the wave characteristics are subsequently investigated. The validity of the present method is confirmed by way of the comparison with available references, and the convergence is discussed. The corresponding phase velocity dispersion curves, displacement distributions and Poynting vectors are illustrated. The influences of the variation in the radius to thickness ratio, angular measure and gradient index on the guided wave characteristics are discussed, which can be used as significant guidance on ultrasonic guided wave non-destructive testing for functionally graded cylindrical structures with sector cross-sections.
Quality characteristics of wheat flour dough and bread containing grape pomace flour
Authors: Šporin Monika , Avbelj Martina , Kovač Boris , Možina Sonja Smole
Published: December 2017

Wheat bread was enriched with 6%, 10% and 15% dried and milled grape pomace flour from two grape cultivars: ‘Merlot’ and ‘Zelen’. Rheological, textural, sensory and antioxidant properties of the enriched dough and bread were evaluated, and compared to control samples. Grape cultivar had significant impact on the rheological characteristics of the dough, and on the sensory and antioxidant properties of the final bread. Development time and dough stability were longer when ‘Merlot’ grape pomace flour was added compared to ‘Zelen’ grape pomace flour and the control. Grape pomace flour addition affected bread volume, firmness, crumb and crust colour, and odour and taste intensity. Moreover, grape pomace flour addition resulted in a stickier and less springy crumb texture, and some negative sensorial properties, such as increased intensity of aftertaste and sand feeling in the mouth. The phenolic content and antioxidant activity of bread were positively correlated with grape pomace flour addition ( r = 0.987, p = 0.01 and r = 0.941, p = 0.01 between phenolic content and ferric reducing antioxidant power and phenolic content and 2,2-diphenyl-1-picrylhydrazyl, respectively). The highest total phenolic contents were 5.92 mg gallic acid equivalents (GAE)/g dw for ‘Merlot’ and 3.65 mg gallic acid equivalents /g dw for ‘Zelen’, which were seen for the bread prepared with the highest grape pomace flour addition (15%). The highest antioxidant activity determined by the 2,2-diphenyl-1-picrylhydrazyl and ferric reducing antioxidant power assays were seen for the bread prepared with the highest ‘Merlot’ grape pomace flour addition (15%). Dough characteristic and sensory profile are strongly influenced by cultivar of grape pomace flour. Based on results of sensory profiling, the variety ‘Zelen’ is suggested for use.
Hypoxia Stress Modifies Na+/K+-ATPase, H+/K+-ATPase, Na+/NH4+-ATPase, and nkaα1 Isoform Expression in the Brain of Immune-Challenged Air-Breathing Fish
Authors: Peter MC Subhash , Simi Satheesan
Published: December 2017

Fishes are equipped to sense stressful stimuli and are able to respond to environmental stressor such as hypoxia with varying pattern of stress response. The functional attributes of brain to hypoxia stress in relation to ion transport and its interaction during immune challenge have not yet delineated in fish. We, therefore, explored the pattern of ion transporter functions and messenger RNA (mRNA) expression of α1-subunit isoforms of Na+/K+-ATPase (NKA) in the brain segments, namely, prosencephalon (PC), mesencephalon (MC), and metencephalon (MeC) in an obligate air-breathing fish exposed either to hypoxia stress (30 minutes forced immersion in water) or challenged with zymosan treatment (25-200 ng g−1 for 24 hours) or both. Zymosan that produced nonspecific immune responses evoked differential regulation of NKA, H+/K+-ATPase (HKA), and [Formula: see text] (NNA) in the varied brain segments. On the contrary, hypoxia stress that demanded activation of NKA in PC and MeC showed a reversed NKA activity pattern in MeC of immune-challenged fish. A compromised HKA and NNA regulation during hypoxia stress was found in immune-challenged fish, indicating the role of these brain ion transporters to hypoxia stress and immune challenges. The differential mRNA expression of α1-subunit isoforms of NKA, nkaα1a, nkaα1b, and nkaα1c, in hypoxia-stressed brain showed a shift in its expression pattern during hypoxia stress-immune interaction in PC and MC. Evidence is thus presented for the first time that ion transporters such as HKA and NNA along with NKA act as functional brain markers which respond differentially to both hypoxia stress and immune challenges. Taken together, the data further provide evidence for a differential Na+, K+, H+, and [Formula: see text] ion signaling that exists in brain neuronal clusters during hypoxia stress-immune interaction as a result of modified regulations of NKA, HKA, and NNA transporter functions and nkaα1 isoform regulation.
Possibility of elasto-hydrostatic evolved-gas bearing as one of the mechanisms of superlubricity
Authors: Kato Takahisa , Matsuoka Hiroshige , Kawaguchi Masahiro , Nosaka Masataka
Published: December 2017

In this article, firstly the experiments previously reported have been reviewed. That is, in the experiments conducted earlier it was seen that the friction coefficient reduced to the friction-tester noise-level of 0.0001, and only a small amount of sliding marks was seen on the tribofilm by scanning electron microscopic observation even though the maximum Hertzian contact pressure was 2.6 GPa. Based on these measurements, the possibility of elasto-hydrostatic gas bearing as the mechanism of super-low friction coefficient, where gas is not supplied from outside of the contact area but evolved from the contact surface, is investigated in the present report. Assuming the evolution of hydrocarbon gas mixture by ZrO2 catalytic reaction, which is represented by C2H4 in this report, the hydrostatic pressure distribution at the contact area and the evolved gas amount required for supporting a heavy applied load of 60 N are calculated.
Tribological compatibility analysis of conventional lubricant additives with palm trimethylolpropane ester (TMP) and tetrahedral amorphous diamond-like carbon coating (ta-C)
Authors: Zahid Rehan , Mufti Riaz Ahmad , Gulzar Mubashir , Bin Haji Hassan Masjuki , Alabdulkarem Abdullah , Varman Mahendra , Kalam Md Abul , Binti Mohd Zulkifli Nurin Wahidah , Yunus Robiah
Published: December 2017

Modern industrial applications involve rigorous operating conditions due to which lubricant either slips out of the contact or its thin layer resides between the interacting surfaces. Deposition of diamond-like carbon coatings and using lubricants capable of physically adsorbing on the interacting surfaces can significantly improve tribological performance. In this study, tribological compatibility of glycerol mono-oleate, molybdenum dithiocarbamate and zinc dialkyldithiophosphate with palm trimethylolpropane ester and tetrahedral amorphous diamond-like carbon coating has been investigated using universal wear testing machine. For comparison, additive-free and formulated versions of polyalphaolefin were used. Moreover, spectroscopic techniques were used to investigate mechanisms responsible for a particular tribological behavior. Among base oils, trimethylolpropane ester proved to be more effective in enhancing friction performance and mitigating wear of contacts when one of the interacting surfaces was ferrous-based. Self-mated tetrahedral amorphous diamond-like carbon coating surfaces resulted in lowest values of friction and wear coefficient of balls.
Drug-related deaths: Statistics based on death certificates miss one-third of cases
Authors: Fugelstad Anna , Ramstedt Mats , Thiblin Ingemar , Johansson Lars Age
Published: December 2017

Aims: Statistics on drug-related deaths (DRD) provide crucial information on the drug situation. The European Monitoring Centre for Drug and Drug Addiction (EMCDDA) has published a specification for extracting DRD from national mortality registers to be used in international comparisons. However, surprisingly little is known of the accuracy of DRD statistics derived from national mortality registers. This study assesses the accuracy of Swedish data derived from national mortality registers by comparing it with other sources of data. Methods: We compared five Swedish datasets. Three were derived from national mortality registers, two according to a Swedish specification and one according to the EMCDDA specification. A fourth dataset was based on toxicological analyses. We used a fifth dataset, an inventory of DRD in Stockholm, to assess the completeness and coverage of the Swedish datasets. Results: All datasets were extracted from high-quality registers, but still did not capture all DRD, and both the numbers and demographic characteristics varied considerably. However, the time trends were consistent between the selections. In international comparisons, data completeness and investigation procedures may impact even more on stated numbers. Conclusions: Basing international comparisons on numbers or rates of DRDs gives misleading results, but comparing trends is still meaningful.
A nationwide Danish survey on the use of green spaces by people with mobility disabilities
Authors: Stigsdotter Ulrika K. , Corazon Sus Sola , Ekholm Ola
Published: December 2017

Background: There is increasing awareness of the importance and health benefits of living near green spaces. Research usually focuses on the general population’s use of green spaces and there has been little focus on the use of green spaces by specific groups, such as people with mobility disabilities. This represents a significant knowledge gap with regard to facilitating access to healthy green environments by all population groups. This study aims to provide knowledge of the use of green spaces by people with mobility disabilities. Methods: The study was based on data from the Danish Health and Morbidity Survey in 2005. The study participants consisted of 11,238 adult Danes, 383 of whom reported mobility disabilities, meaning that they were dependent on assistive devices for walking or moving around. Multiple logistic regression analysis was used to investigate the association between mobility disability and use of green spaces. Results: The results show that respondents who reported mobility disabilities visited green spaces less often than respondents without mobility disabilities. The severity of the mobility disability was associated with the frequency of visits. Frequency of visits was also related to the respondents’ health-related quality of life status. Conclusions: These results highlight the need for further research into the constraints faced by people with mobility disabilities with regard to visiting green spaces.
Occupational gender composition and mild to severe depression in a Swedish cohort: The impact of psychosocial work factors
Authors: Nyberg Anna , Magnusson Hanson Linda L. , Leineweber Constanze , Hammarström Anne , Theorell Töres
Published: December 2017

Aims: The aim of the present study was to investigate associations between occupational gender composition, psychosocial work factors and mild to severe depression in Swedish women and men with various educational backgrounds. Methods: The study included 5560 participants from two waves of the Swedish Longitudinal Occupational Survey of Health, an approximately representative sample of the Swedish working population. Odds ratios (OR) and 95% confidence intervals of mild to severe depression in 2014 were estimated for five strata of occupational gender composition with >20–40%, >40–60%, >60–80% and >80–100% women, using 0–20% women as the reference. Analyses were stratified by gender and education. Job strain, organisational injustice, poor social support and effort–reward imbalance in 2012 were added in separate models, and changes in OR of mild to severe depression for strata of occupational gender composition were evaluated. Results: Among women, the odds of mild to severe depression did not vary by occupational gender composition. Among men with low to intermediate education, the odds were higher in the stratum with >80–100% women, and among men with high education, the odds were higher in strata with >20–40% and >60–80% women. Psychosocial work factors affected the odds ratios of mild to severe depression, but most of the variation remained unexplained. Conclusions: Odds of mild to severe depression appeared to vary by occupational gender composition among Swedish men but not women. This variation seemed only to a small extent to be explained by psychosocial work factors.
Contact with primary and mental health care prior to suicide: A systematic review of the literature from 2000 to 2017
Authors: Stene-Larsen Kim , Reneflot Anne
Published: December 2017

Aim: To examine rates of contact with primary and mental health care prior to suicide in men and women and across a range of age categories. Method: The authors performed a systematic review of 44 studies from 2000 to 2017 of which 36 reported rates on contact with primary health care and 14 reported on contact with mental health care prior to suicide. Results: Contact with primary health care was highest in the year prior to suicide with an average contact rate of 80%. At one month, the average rate was 44%. The lifetime contact rate for mental health care was 57%, and 31% in the final 12 months. In general, women and those over 50 years of age had the highest rates of contact with health care prior to suicide. Conclusions: Contact with primary health care prior to suicide is common even in the final month before death. The findings presented in this study highlight the importance of placing suicide prevention strategies and interventions within the primary health care setting.
So scary, yet so fun: The role of self-efficacy in enjoyment of a virtual reality horror game
Authors: Lin Jih-Hsuan Tammy , Wu Dai-Yun , Tao Chen-Chao
Published: December 2017

Enjoyment of frightening content is a paradoxical issue in communication research. Revising Zillmann’s model of suspense, we propose a three-factor model examining the audience appeal of horror content in a virtual reality (VR) survival horror game. In a laboratory study, participants played a VR horror game. The results show significant effects of the three-way interaction among horror self-efficacy, physiological arousal, and fear on enjoyment and future intentions to play similar games. Horror self-efficacy interacts with fear to affect enjoyment only among high-arousal participants. Among high-fear participants, higher horror self-efficacy leads to significantly greater enjoyment than lower horror self-efficacy. We measured enjoyment through self-reported ratings, future intentions to play similar games, and the behavioral choice of subsequent games to demonstrate the appeal of horror content. Horror self-efficacy in coping with mediated fright is the key to explaining the conditional positive association of fear and enjoyment in the gaming context.
In-plane vibration response of time and frequency domain with rigid-elastic coupled tire model with continuous sidewall
Authors: Liu Zhihao , Gao Qinhe
Published: December 2017

The in-plane vibration characteristic of time and frequency domain for heavy-loaded radial tire with a larger flat ratio (close to 1) is researched by utilizing the rigid-elastic coupled tire model with continuous sidewall. The sidewall bending stiffness is considered and the flexible beam on the elastic continuous beam tire model is proposed and investigated analytically to simulate the in-plane vibration of the heavy-loaded radial tire within more wider frequency band. The rigid-elastic coupled tire model is derived with finite difference method and the analytical stiffness matrix; mass matrix is formed based on the geometrical and structural parameters of heavy-loaded radial tire. Structural parameters are identified utilizing genetic algorithm based on the error between the analytical and experimental modal frequency. In-plane frequency domain transfer function and time domain dynamics response of heavy-loaded radial tire is investigated and compared with the experimental result. Experimental and theoretical results show that in-plane rigid-elastic coupled tire model with sidewall bending stiffness can be used to precisely predict the transfer function and vibration feature within the frequency band of 300 Hz, compared with the tire model with the distributed independent sidewall element. The flexible beam on the elastic continuous beam tire model and rigid-elastic coupled tire model with continuous sidewall can be extended to the dynamic analysis of the tire with larger flat ratio or the tire under the impulsive loading conditions.
Three Approaches to Understanding and Classifying Mental Disorder: ICD-11, DSM-5, and the National Institute of Mental Health’s Research Domain Criteria (RDoC)
Authors: Clark Lee Anna , Cuthbert Bruce , Lewis-Fernández Roberto , Narrow William E. , Reed Geoffrey M.
Published: December 2017

The diagnosis of mental disorder initially appears relatively straightforward: Patients present with symptoms or visible signs of illness; health professionals make diagnoses based primarily on these symptoms and signs; and they prescribe medication, psychotherapy, or both, accordingly. However, despite a dramatic expansion of knowledge about mental disorders during the past half century, understanding of their components and processes remains rudimentary. We provide histories and descriptions of three systems with different purposes relevant to understanding and classifying mental disorder. Two major diagnostic manuals—the International Classification of Diseases and the Diagnostic and Statistical Manual of Mental Disorders—provide classification systems relevant to public health, clinical diagnosis, service provision, and specific research applications, the former internationally and the latter primarily for the United States. In contrast, the National Institute of Mental Health’s Research Domain Criteria provides a framework that emphasizes integration of basic behavioral and neuroscience research to deepen the understanding of mental disorder. We identify four key issues that present challenges to understanding and classifying mental disorder: etiology, including the multiple causality of mental disorder; whether the relevant phenomena are discrete categories or dimensions; thresholds, which set the boundaries between disorder and nondisorder; and comorbidity, the fact that individuals with mental illness often meet diagnostic requirements for multiple conditions. We discuss how the three systems’ approaches to these key issues correspond or diverge as a result of their different histories, purposes, and constituencies. Although the systems have varying degrees of overlap and distinguishing features, they share the goal of reducing the burden of suffering due to mental disorder.
Walking and Talking With the Lord: Teleological Curation, Salvation, and the Billy Graham Library
Authors: Crane Jonathan Lake , Davis Christine S.
Published: December 2017

This article offers a critical auto-ethnography of Charlotte’s extensive Billy Graham Library complex, sculpted grounds, and memorial garden. Opened in 2007 and designed as an “ongoing Crusade,” the Billy Graham Library is a notable Evangelical archive. All historical sites are wellsprings curated to convey and preserve a compelling narrative through line that encompasses the meaning of the assembled artifacts on display. The museum is also constructed to win souls to God and bring all visitors to a personal relationship with Jesus Christ, and, we suggest, to usher visitors to an irredentist vision of Christ’s kingdom.
Patient-Specific Quality Assurance Using Monte Carlo Dose Calculation and Elekta Log Files for Prostate Volumetric-Modulated Arc Therapy
Authors: Katsuta Yoshiyuki , Kadoya Noriyuki , Fujita Yukio , Shimizu Eiji , Matsunaga Kenichi , Sawada Kinya , Matsushita Haruo , Majima Kazuhiro , Jingu Keiichi
Published: December 2017

Log file–based methods are attracting increasing interest owing to their ability to validate volumetric-modulated arc therapy outputs with high resolution in the leaf and gantry positions and in delivered dose. Cross-validation of these methods for comparison with measurement-based methods using the ionization chamber/ArcCHECK-3DVH software (version 3.2.0) under the same conditions of treatment anatomy and plan enables an efficient evaluation of this method. In this study, with the purpose of cross-validation, we evaluate the accuracy of a log file–based method using Elekta log files and an X-ray voxel Monte Carlo dose calculation technique in the case of leaf misalignment during prostate volumetric-modulated arc therapy. In this study, 10 prostate volumetric-modulated arc therapy plans were used. Systematic multileaf collimator leaf positional errors (±0.4 and ±0.8 mm for each single bank) were deliberately introduced into the optimized plans. Then, the delivered 3-dimensional doses to a phantom with a certain patient anatomy were estimated by our system. These doses were compared with the ionization chamber dose and the ArcCHECK-3DVH dose. For the given phantom and patient anatomy, the estimated dose strongly coincided with the ionization chamber/ArcCHECK-3DVH dose ( P < .01). In addition, good agreement between the estimated dose and the ionization chamber/ArcCHECK-3DVH dose was observed. The dose estimation accuracy of our system, which combines Elekta log files and X-ray voxel Monte Carlo dose calculation, was evaluated.
Can Persistence With Cholinesterase Inhibitor Treatment Lower Mortality and Health-Care Costs Among Patients With Alzheimer’s Disease? A Population-Based Study in Taiwan
Authors: Ku Li-Jung Elizabeth , Li Chung-Yi , Sun Yu
Published: December 2017

Although cholinesterase inhibitors (ChEIs) have been proved to help reduce cognitive deterioration in patients with Alzheimer’s disease (AD), their effects on survival remain inconclusive. This study aims to assess the effects of the persistent use of ChEIs on the risk of mortality in patients with AD. This population-based cohort study included 8614 patients having AD with ChEI prescription from 2002 to 2006 and followed until 2010. Kaplan-Meier curves and hazard ratios (HRs) of mortality were estimated in association with ChEI treatment duration and adherence. The average annual mortality rate per 100 person-years was 9.2 for the short-duration group (discontinued < 1 year) and 7.2 for the long-duration group (discontinued ≥ 2 years). Compared to the short-duration group, the long-duration group had a lower mortality (HR = 0.76, 95% confidence interval: 0.69-0.84) and shorter annual inpatient days. But the annual health-care costs did not differ significantly between the 2 groups.
The Contribution of Supplementary Tests in the Differential Diagnosis of Dementia
Authors: de Moraes Fabiano Moulin , Bertolucci Paulo Ferreira
Published: December 2017

Introduction:

Supplementary tests are part of the clinical approach to diagnose cognitive impairment. We aimed to determine the role of supplementary examinations, except for biomarkers, on diagnostic stability of dementia over time and to identify reversible dementias.

Methods:

We identified 432 patients with dementia who performed 2 clinical evaluations and the supplementary examinations recommended by the American Academy of Neurology in a follow-up period of 1 year.

Results:

In this sample, 110 (24.5%) patients changed their diagnosis at 1-year follow-up for the appearance of vascular cognitive impairment than the initial diagnosis, due to the neuroimaging. Concerning the reversible dementias, depression was the major differential diagnosis, detected in 13 (81%) of the 16 patients with cognitive improvement.

Conclusion:

Therefore, regarding the supplementary examinations only neuroimaging and the depression triage were relevant for clinical practice regarding the differential diagnosis of dementia.
Dual Effects of N,N-dimethylformamide on Cell Proliferation and Apoptosis in Breast Cancer
Authors: Zhang Jihong , Zhou Daibing , Zhang Lingyun , Lin Qunbo , Ren Weimin , Zhang Jinguo , Nadeem Lubna , Xu Guoxiong
Published: December 2017

N,N-dimethylformamide (DMF) has been widely used as an organic solvent in industries. DMF is a potential medication. However, the antitumorigenic role of DMF in breast cancer remains unclear. Here, we examined dose-dependent effects of DMF on proliferation and apoptosis in breast cancer MCF-7 and nontumorous MCF-12A cells. We found that DMF had a growth inhibitory effect in MCF-12A cells in a dose-dependent manner. By contrast, however, DMF had dual effects on cell proliferation and apoptosis in MCF-7 cells. DMF at a high dose (100 mM) significantly inhibited MCF-7 cell growth while at a low dose (1 mM) significantly stimulated MCF-7 cell growth (both P < .05). The inhibitory effect of DMF on cell proliferation was accompanied by the decrease of cyclin D1 and cyclin E1 protein expression, leading to the cell cycle arrest at the G0/G1 phase. Furthermore, a high-dose DMF significantly increased the number of early apoptotic cells by increasing cleaved caspase-9 and proapoptotic protein Bax expression and decreased the ratio of Bcl-xL/Bax ( P < .01). Thus, our data demonstrated for the first time that DMF has dual effects on breast cancer cell behaviors depending upon its dose. Caution must be warranted in determining its effective dose for targeting breast cancer.
Developmental Aspects of Unintentional Injury Prevention Among Youth: Implications for Practice
Authors: Barton Benjamin K. , Shen Jiabin , Stavrinos Despina , Davis Shane
Published: December 2017

Unintentional injuries, the leading cause of morbidity and mortality among youth in the United States, are burdensome and costly to society. Continued prevention efforts to reduce rates of unintentional injury remain imperative. We emphasized the role of practitioner influence across a linear concept of injury prevention comprising delivery, practice, and application/generalization and within the context of child developmental factors. Specific strategies for injury prevention tailored to the cognitive development stage of the patient are provided. This information may be useful to health care practitioners, who have significant interaction with youth and their families.
Exploring Cultural Disengagement: The Example of Chile
Authors: Gayo Modesto
Published: December 2017

Research on cultural capital has been very attentive to cultural participation. In numerous explorations of the social basis of participatory practices, a division between cultural engagement and disengagement has been frequently observed. In accordance with Bourdieu’s seminal work on taste, that divide has been predominantly associated with social class issues. But research has only weakly explored the rationale behind people’s behaviours in this regard. This article explores rationales for non-participation and reaches significant conclusions about these. First, non-participatory practices are very much spread across the social structure, and they are associated with different reasons (disliking, lack of time, money, information, habits, and access to venues). Second, the reasons provided by survey interviewees are affected differently by income levels, age and the size of the places people live in, amongst other important variables. Third, even though the effect of those variables on the reasons changes according to the legitimacy of the activities in which interviewees do not take part in, differences related to the status of the activities are less significant than similarities. I use data from Chile, collected in 2012, and the findings are linked to those of previous analyses undertaken in other countries.
Prevalence of maternal urinary ketones in pregnancy in overweight and obese women
Authors: Robinson Helen L , Barrett Helen L , Foxcroft Katie , Callaway Leonie K , Dekker Nitert Marloes
Published: December 2017

Background

Ketonuria may be associated with adverse fetal outcomes. This study aimed to determine the prevalence of ketonuria at three time points in pregnancy and to assess whether ketonuria correlates with a clinical indication for performing a urine test.

Methods

Women had fasting urinary ketone levels measured at 16 and 28 weeks gestation and random ketone levels measured close to 36 weeks gestation. All ketone levels in the third trimester were recorded along with the clinical indication for the test.

Results

One hundred and eighty-seven women were included in the study. Twenty-two per cent of women had ketonuria at either 16 or 28 weeks gestation and 8% at 36 weeks gestation. Ketonuria was significantly more likely if a test was performed for a clinical indication ( p = 0.0002).

Conclusion

Ketonuria in pregnancy is common affecting at least one in five women. Ketonuria is more common in women who have a clinical indication for performing a urine test.
Hip and knee arthroplasty
Authors: Marley Dominic , Sheikh Nomaan , Taylor John , Kumar Amit
Published: December 2017

The incidence of hip and knee replacement surgery has risen dramatically in recent years. The latest National Joint Registry figures indicate that almost 190 000 total hip and knee replacements were performed in 2015. The aim of this article is to discuss the management of hip and knee pain in primary care, the indications for hip and knee arthroplasty and surgical considerations.
Anterior Inferior Iliac Spine Deformity as a Cause for Extra-articular Hip Impingement in Young Athletes After an Avulsion Fracture: A Case Report
Authors: Novais Eduardo N. , Riederer Mark F. , Provance Aaron J.
Published: December 2017

Extra-articular hip impingement from prior traumatic injury to the anterior inferior iliac spine (AIIS) is an uncommon cause of groin pain in young athletes. Currently, the most common treatment for this injury is arthroscopic decompression. However, hip arthroscopy is not universally available and requires advanced skills. We report 2 cases of the development of extra-articular hip impingement from unusual bony exostoses off the AIIS after traumatic injury in 2 young athletes who underwent open surgical resection. The multidisciplinary sports medicine team should be aware of the development of extra-articular impingement from traumatic injury to the AIIS and that open surgical resection is a viable alternative to arthroscopic decompression.
Gender Roles and Employment Pathways of Older Women and Men in England
Authors: van der Horst Mariska , Lain David , Vickerstaff Sarah , Clark Charlotte , Baumberg Geiger Ben
Published: December 2017

In the context of population aging, the U.K. government is encouraging people to work longer and delay retirement, and it is claimed that many people now make “gradual” transitions from full-time to part-time work to retirement. Part-time employment in older age may, however, be largely due to women working part-time before older age, as per a U.K. “modified male breadwinner” model. This article therefore separately examines the extent to which men and women make transitions into part-time work in older age, and whether such transitions are influenced by marital status. Following older men and women over a 10-year period using the English Longitudinal Study of Ageing, this article presents sequence, cluster, and multinomial logistic regression analyses. Little evidence is found for people moving into part-time work in older age. Typically, women did not work at all or they worked part-time (with some remaining in part-time work and some retiring/exiting from this activity). Consistent with a “modified male breadwinner” logic, marriage was positively related to the likelihood of women belonging to typically “female employment pathway clusters,” which mostly consist of part-time work or not being employed. Men were mostly working full-time regardless of marital status. Attempts to extend working lives among older women are therefore likely to be complicated by the influence of traditional gender roles on employment.
Sociodemographic Characteristics, Health Literacy, and Care Compliance in Families With Spina Bifida
Authors: Cooper Jennifer , Chisolm Deena , McLeod Daryl J.
Published: December 2017

Children with spina bifida experience varying rates of disease complications and health system overutilization. Data on sociodemographics, urinary tract infection, clean intermittent catheterization, and health system utilization were collected from caregiver-patient dyads. Newest Vital Sign (NVS) and Brief Health Literacy Screen (BRIEF) were administered to evaluate health literacy (HL). In total, 105 dyads completed enrolment with 24.8% versus 12.4% of caregivers scoring poor/marginal on the NVS and BRIEF, respectively. Nearly half on clean intermittent catheterization missed a catheterization over the previous week. Medicaid insurance, parental education, and household income predicted HL ( P < .01). Over the preceding 5 years, 68.5% visited our hospital’s emergency department. Eighteen (25%) visited the emergency department >6 times and 12 incurred charges over $50 000. Caregivers of children who missed ≥4 catheterizations per week had lower NVS scores ( P = .03). Children with spina bifida represent high utilizers, and consideration of sociodemographic and HL differences is necessary when tailoring care plans.
Syndecan-1 promotes Wnt/β-catenin signaling in multiple myeloma by presenting Wnts and R-spondins
Authors: Ren Zemin , van Andel Harmen , de Lau Wim , Hartholt Robin B. , Maurice Madelon M. , Clevers Hans , Kersten Marie José , Spaargaren Marcel , Pals Steven T.
Published: December 2017

Key Points

HS chains decorating syndecan-1 promote autocrine and paracrine Wnt signaling in MM. Loss of HS inhibits MM cell growth by attenuating Wnt signaling.
Soluble interleukin-2 receptor is a sensitive diagnostic test in adult HLH
Authors: Hayden Anna , Lin Molly , Park Sujin , Pudek Morris , Schneider Marion , Jordan Michael B. , Mattman Andre , Chen Luke Y. C.
Published: December 2017

Key Points

The optimal cutoff for soluble interleukin-2 receptor in this study was 2515 U/mL (sensitivity, 100%; specificity, 72.5%). sIL-2r ≤2400 U/mL is helpful for ruling out HLH (sensitivity, 100%) and >10 000 U/mL is helpful for ruling it in (specificity, 93%).