bluuebunny/crossref_metadata_2025 huggingface dataset:
Comparative Genomics Identifies the Evolutionarily Conserved Gene TPM3 as a Target of eca-miR-1 Involved in the Skeletal Muscle Development of Donkeys
Authors: Yang Ge , Sun Minhao , Wang Zhaofei , Hu Qiaoyan , Guo Jiajun , Yu Jie , Lei Chuzhao , Dang Ruihua
Published: October 2023

Species within the genus Equus are valued for their draft ability. Skeletal muscle forms the foundation of the draft ability of Equus species; however, skeletal muscle development-related conserved genes and their target miRNAs are rarely reported for Equus. In this study, a comparative genomics analysis was performed among five species (horse, donkey, zebra, cattle, and goat), and the results showed that a total of 15,262 (47.43%) genes formed the core gene set of the five species. Only nine chromosomes (Chr01, Chr02, Chr03, Chr06, Chr10, Chr18, Chr22, Chr27, Chr29, and Chr30) exhibited a good collinearity relationship among Equus species. The micro-synteny analysis results showed that TPM3 was evolutionarily conserved in chromosome 1 in Equus. Furthermore, donkeys were used as the model species for Equus to investigate the genetic role of TPM3 in muscle development. Interestingly, the results of comparative transcriptomics showed that the TPM3 gene was differentially expressed in donkey skeletal muscle S1 (2 months old) and S2 (24 months old), as verified via RT-PCR. Dual-luciferase test analysis showed that the TPM3 gene was targeted by differentially expressed miRNA (eca-miR-1). Furthermore, a total of 17 TPM3 gene family members were identified in the whole genome of donkey, and a heatmap analysis showed that EaTPM3-5 was a key member of the TPM3 gene family, which is involved in skeletal muscle development. In conclusion, the TPM3 gene was conserved in Equus, and EaTPM3-5 was targeted by eca-miR-1, which is involved in skeletal muscle development in donkeys.
Innate Immunity in Autoimmune Thyroid Disease during Pregnancy
Authors: Bogović Crnčić Tatjana , Girotto Neva , Ilić Tomaš Maja , Krištofić Ines , Klobučar Sanja , Batičić Lara , Ćurko-Cofek Božena , Sotošek Vlatka
Published: October 2023

Autoimmune thyroid disease (AITD) is the most common organ-specific autoimmune disorder clinically presented as Hashimoto thyroiditis (HT) and Graves’ disease (GD). The pathogenesis of AITD is caused by an inappropriate immune response related to genetic, non-genetic, and environmental factors. Pregnancy is one of the factors that have a great influence on the function of the thyroid gland because of the increased metabolic demand and the effects of hormones related to pregnancy. During pregnancy, an adaptation of the maternal immune system occurs, especially of the innate immune system engaged in maintaining adaptive immunity in the tolerant state, preventing the rejection of the fetus. Pregnancy-related hormonal changes (estrogen, progesterone, hCG) may modulate the activity of innate immune cells, potentially worsening the course of AITD during pregnancy. This especially applies to NK cells, which are associated with exacerbation of HD and GD. On the other hand, previous thyroid disorders can affect fertility and cause adverse outcomes of pregnancy, such as placental abruption, spontaneous abortion, and premature delivery. Additionally, it can cause fetal growth retardation and may contribute to impaired neuropsychological development of the fetus. Therefore, maintaining the thyroid equilibrium in women of reproductive age and in pregnant women is of the highest importance.
Investigation on the Structural and Photocatalytic Performance of Oxygen-Vacancy-Enriched SnO2-CeO2 Heterostructures
Authors: Yang Daixiong , Xia Yangwen , Zhang Ling , Liu Jiawei , Zhu Xiaodong , Feng Wei
Published: October 2023

In this study, pure CeO2 and oxygen-vacancy-enriched SnO2-CeO2 composite materials were prepared using the sol–gel method, and their microstructures and photocatalytic properties were investigated. The results indicate that SnO2 coupling promotes the separation and transfer of photogenerated electrons and holes and suppresses their recombination. The 50% SnO2-CeO2 composite material exhibited a decreased specific surface area compared to pure CeO2 but significantly increased oxygen vacancy content, demonstrating the highest photogenerated charge separation efficiency and the best photocatalytic performance. After 120 min of illumination, the degradation degree of MB by the 50% SnO2-CeO2 composite material increased from 28.8% for pure CeO2 to 90.8%, and the first-order reaction rate constant increased from 0.002 min−1 to 0.019 min−1.
ACP-BC: A Model for Accurate Identification of Anticancer Peptides Based on Fusion Features of Bidirectional Long Short-Term Memory and Chemically Derived Information
Authors: Sun Mingwei , Hu Haoyuan , Pang Wei , Zhou You
Published: October 2023

Anticancer peptides (ACPs) have been proven to possess potent anticancer activities. Although computational methods have emerged for rapid ACPs identification, their accuracy still needs improvement. In this study, we propose a model called ACP-BC, a three-channel end-to-end model that utilizes various combinations of data augmentation techniques. In the first channel, features are extracted from the raw sequence using a bidirectional long short-term memory network. In the second channel, the entire sequence is converted into a chemical molecular formula, which is further simplified using Simplified Molecular Input Line Entry System notation to obtain deep abstract features through a bidirectional encoder representation transformer (BERT). In the third channel, we manually selected four effective features according to dipeptide composition, binary profile feature, k-mer sparse matrix, and pseudo amino acid composition. Notably, the application of chemical BERT in predicting ACPs is novel and successfully integrated into our model. To validate the performance of our model, we selected two benchmark datasets, ACPs740 and ACPs240. ACP-BC achieved prediction accuracy with 87% and 90% on these two datasets, respectively, representing improvements of 1.3% and 7% compared to existing state-of-the-art methods on these datasets. Therefore, systematic comparative experiments have shown that the ACP-BC can effectively identify anticancer peptides.
Roles of Oxidative Injury and Nitric Oxide System Derangements in Kawasaki Disease Pathogenesis: A Systematic Review
Authors: Tsuge Mitsuru , Uda Kazuhiro , Eitoku Takahiro , Matsumoto Naomi , Yorifuji Takashi , Tsukahara Hirokazu
Published: October 2023

Kawasaki disease (KD) is an acute febrile vasculitis that occurs mostly in children younger than five years. KD involves multiple intricately connected inflammatory reactions activated by a cytokine cascade. Despite therapeutic advances, coronary artery damage may develop in some patients, who will be at risk of clinical cardiovascular events and even sudden death. The etiology of KD remains unclear; however, it may involve both genetic and environmental factors leading to aberrant inflammatory responses. Given the young age of onset, prenatal or perinatal exposure may be etiologically relevant. Multisystem inflammatory syndrome in children, a post-infectious hyper-inflammatory disorder associated with severe acute respiratory syndrome coronavirus 2, has features that overlap with those of KD. Available evidence indicates that vascular endothelial dysfunction is a critical step in the sequence of events leading to the development of cardiovascular lesions in KD. Oxidative stress and the dysregulation of the nitric oxide (NO) system contribute to the pathogenesis of inflammatory responses related to this disease. This review provides current evidence and concepts highlighting the adverse effects of oxidative injury and NO system derangements on the initiation and progression of KD and potential therapeutic strategies for cardiovascular pathologies in affected children.
Optimizing Eco-Friendly Degradation of Polyvinyl Chloride (PVC) Plastic Using Environmental Strains of Malassezia Species and Aspergillus fumigatus
Authors: El-Dash Heba A. , Yousef Nehal E. , Aboelazm Abeer A. , Awan Zuhier A. , Yahya Galal , El-Ganiny Amira M.
Published: October 2023

Worldwide, huge amounts of plastics are being introduced into the ecosystem, causing environmental pollution. Generally, plastic biodegradation in the ecosystem takes hundreds of years. Hence, the isolation of plastic-biodegrading microorganisms and finding optimum conditions for their action is crucial. The aim of the current study is to isolate plastic-biodegrading fungi and explore optimum conditions for their action. Soil samples were gathered from landfill sites; 18 isolates were able to grow on SDA. Only 10 isolates were able to the degrade polyvinyl chloride (PVC) polymer. Four isolates displayed promising depolymerase activity. Molecular identification revealed that three isolates belong to genus Aspergillus, and one isolate was Malassezia sp. Three isolates showed superior PVC-biodegrading activity (Aspergillus-2, Aspergillus-3 and Malassezia) using weight reduction analysis and SEM. Two Aspergillus strains and Malassezia showed optimum growth at 40 °C, while the last strain grew better at 30 °C. Two Aspergillus isolates grew better at pH 8–9, and the other two isolates grow better at pH 4. Maximal depolymerase activity was monitored at 50 °C, and at slightly acidic pH in most isolates, FeCl3 significantly enhanced depolymerase activity in two Aspergillus isolates. In conclusion, the isolated fungi have promising potential to degrade PVC and can contribute to the reduction of environmental pollution in eco-friendly way.
Tryptophan-Starved Human Cells Overexpressing Tryptophanyl-tRNA Synthetase Enhance High-Affinity Tryptophan Uptake via Enzymatic Production of Tryptophanyl-AMP
Authors: Yokosawa Takumi , Wakasugi Keisuke
Published: October 2023

Our previous study demonstrated that L-tryptophan (Trp)-depleted cells display a marked enhancement in Trp uptake facilitated by extracellular tryptophanyl-tRNA synthetase (TrpRS). Here, we show that Trp uptake into TrpRS-overexpressing cells is also markedly elevated upon Trp starvation. These findings indicate that a Trp-deficient condition is critical for Trp uptake, not only into cells to which TrpRS protein has been added but also into TrpRS-overexpressing cells. We also show that overexpression of TrpRS mutants, which cannot synthesize tryptophanyl-AMP, does not promote Trp uptake, and that inhibition of tryptophanyl-AMP synthesis suppresses this uptake. Overall, these data suggest that tryptophanyl-AMP production by TrpRS is critical for high-affinity Trp uptake.
Activation of the TNF-α-Necroptosis Pathway in Parvalbumin-Expressing Interneurons of the Anterior Cingulate Cortex Contributes to Neuropathic Pain
Authors: Duan Yiwen , Li Qiaoyun , Zhou Yaohui , Chen Shaoxia , Li Yongyong , Zang Ying
Published: October 2023

The hyperexcitability of the anterior cingulate cortex (ACC) has been implicated in the development of chronic pain. As one of the key causes of ACC hyperexcitation, disinhibition of the ACC may be closely related to the dysfunction of inhibitory parvalbumin (PV)-expressing interneurons (PV-INs). However, the molecular mechanism underlying the ACC PV-INs injury remains unclear. The present study demonstrates that spared sciatic nerve injury (SNI) induces an imbalance in the excitation and inhibition (E/I) of the ACC. To test whether tumor necrosis factor-α (TNF-α) upregulation in the ACC after SNI activates necroptosis and participates in PV-INs damage, we performed a differential analysis of transcriptome sequencing using data from neuropathic pain models and found that the expression of genes key to the TNF-α-necroptosis pathway were upregulated. TNF-α immunoreactivity (IR) signals in the ACCs of SNI rats were co-located with p-RIP3- and PV-IR, or p-MLKL- and PV-IR signals. We then systematically detected the expression and cell localization of necroptosis-related proteins, including kinase RIP1, RIP3, MLKL, and their phosphorylated states, in the ACC of SNI rats. Except for RIP1 and MLKL, the levels of these proteins were significantly elevated in the contralateral ACC and mainly expressed in PV-INs. Blocking the ACC TNF-α-necroptosis pathway by microinjecting TNF-α neutralizing antibody or using an siRNA knockdown to block expression of MLKL in the ACC alleviated SNI-induced pain hypersensitivity and inhibited the upregulation of TNF-α and p-MLKL. Targeting TNF-α-triggered necroptosis within ACC PV-INs may help to correct PV-INs injury and E/I imbalance in the ACC in neuropathic pain.
Disrupted Neural Regeneration in Dry Eye Secondary to Ankylosing Spondylitis—With a Theoretical Link between Piezo2 Channelopathy and Gateway Reflex, WDR Neurons, and Flare-Ups
Authors: Sonkodi Balázs , Marsovszky László , Csorba Anita , Balog Attila , Kopper Bence , Keller-Pintér Anikó , Nagy Zoltán Zsolt , Resch Miklós D.
Published: October 2023

This study aimed at analyzing the corneal neural regeneration in ankylosing spondylitis patients using in vivo corneal confocal microscopy in correlation with Langerhans cell density, morphology, and dry eye parameters. Approximately 24 ankylosing spondylitis subjects and 35 age- and gender-matched control subjects were enrolled. Data analysis showed that all corneal nerve-fiber descriptives were lower in the ankylosing spondylitis group, implicating disrupted neural regeneration. Peripheral Langerhans cell density showed a negative correlation with nerve fiber descriptions. A negative correlation between tear film break-up time and corneal nerve fiber total branch density was detected. The potential role of somatosensory terminal Piezo2 channelopathy in the pathogenesis of dry eye disease and ankylosing spondylitis is highlighted in our study, exposing the neuroimmunological link between these diseases. We hypothesized earlier that spinal neuroimmune-induced sensitization due to this somatosensory terminal primary damage could lead to Langerhans cell activation in the cornea, in association with downregulated Piezo1 channels on these cells. This activation could lead to a Th17/Treg imbalance in dry eye secondary to ankylosing spondylitis. Hence, the corneal Piezo2 channelopathy-induced impaired Piezo2-Piezo1 crosstalk could explain the disrupted neural regeneration. Moreover, the translation of our findings highlights the link between Piezo2 channelopathy-induced gateway to pathophysiology and the gateway reflex, not to mention the potential role of spinal wide dynamic range neurons in the evolution of neuropathic pain and the flare-ups in ankylosing spondylitis and dry eye disease.
The Effect of Cation Incorporation on the Elastic and Vibrational Properties of Mixed Lead Chloride Perovskite Single Crystals
Authors: Junaid Syed Bilal , Naqvi Furqanul Hassan , Ko Jae-Hyeon
Published: October 2023

In recent years, there have been intense studies on hybrid organic–inorganic compounds (HOIPs) due to their tunable and adaptable features. This present study reports the vibrational, structural, and elastic properties of mixed halide single crystals of MAxFA1-xPbCl3 at room temperature by introducing the FA cation at the A-site of the perovskite crystal structure. Powder X-ray diffraction analysis confirmed that its cubic crystal symmetry is similar to that of MAPbCl3 and FAPbCl3 with no secondary phases, indicating a successful synthesis of the MAxFA1-xPbCl3 mixed halide single crystals. Structural analysis confirmed that the FA substitution increases the lattice constant with increasing FA concentration. Raman spectroscopy provided insight into the vibrational modes, revealing the successful incorporation of the FA cation into the system. Brillouin spectroscopy was used to investigate the changes in the elastic properties induced via the FA substitution. A monotonic decrease in the sound velocity and the elastic constant suggests that the incorporation of large FA cations causes distortion within the inorganic framework, altering bond lengths and angles and ultimately resulting in decreased elastic constants. An analysis of the absorption coefficient revealed lower attenuation coefficients as the FA content increased, indicating reduced damping effects and internal friction. The current findings can facilitate the fundamental understanding of mixed lead chloride perovskite materials and pave the way for future investigations to exploit the unique properties of mixed halide perovskites for advanced optoelectronic applications.
Joint Dysfunction as a Cause of Spontaneous Subclinical Bleeding in Infants with Hemophilia
Authors: Boccalandro Elena Anna , Pasca Samantha , Begnozzi Valentina , Gualtierotti Roberta , Mannucci Pier Mannuccio
Published: October 2023

Hemophilia is an inherited hemorrhagic disorder; its main clinical manifestations being bleeding in muscles and joints. Ankles, knees, and elbows are the most frequently affected joints, followed by shoulders and hips. The clinical signs of joint involvement are reduced mobility, swelling and walking difficulties. Bleeding episodes in patients with hemophilia are usually divided into traumatic and spontaneous, but we believe that the latter are not truly spontaneous but rather the result of joint stresses owing to motion actions that create dysfunctions starting from infancy. Pharmacological prophylaxis with factor replacement therapies or non-replacement drugs markedly reduces musculoskeletal hemorrhages. However, the onset of subclinical joint stress can be reduced only by associating this therapeutic approach with the accurate observation of the child motion patterns and restoring them if dysfunctional, thereby primarily preventing subclinical bleeding and ultimately the onset or progression of hemophilic arthropathy.
The Subcutaneous Implantable Cardioverter-Defibrillator: A Patient Perspective
Authors: Nesti Martina , Russo Vincenzo , Palamà Zefferino , Panchetti Luca , Garibaldi Silvia , Startari Umberto , Mirizzi Gianluca , Piacenti Marcello , Rossi Andrea , Sciarra Luigi
Published: October 2023

The subcutaneous implantable cardioverter-defibrillator (S-ICD) is a new technology for the management of ICD patients. But what is the patients’ perspective? Previous studies on the transvenous ICD (TV-ICD) showed that device implantation is related not only to anxiety and depression because of the fear of ICD shocks, but also to many biopsychosocial factors like body image changes, perceived reduction of socialization and limitation in professional and sports activities. Anxiety and distress are more evident in younger women because of aesthetic reasons. The scar size and the position of the S-ICD can help these patients and positively influence their social relationships. Moreover, the position of the S-ICD reduces possible complications from catheters due to stress injury and can improve patients’ professional life by avoiding some work activity limitations. An S-ICD can be also a good option for athletes in avoiding subclavian crash and reducing inappropriate shocks. However, some questions remain unsolved because an S-ICD is not suitable for patients with indications for pacing, cardiac resynchronization therapy or anti-tachycardia pacing. In conclusion, the use of an S-ICD can assist physicians in reducing the negative impact of implantation on the well-being of some groups of patients by helping them to avoid depression and anxiety as well as improving their noncompliance with their medical treatment.
Association of a Bioimpedance Profile with Optical Coherence Tomography Features in Diabetic Macular Edema
Authors: Hwang Sunjin , Seong Mincheol , Kang Min Ho , Thng Zheng Xian , Cho Heeyoon , Shin Yong Un
Published: October 2023

We examined the association between bioimpedance profiles and optical coherence tomography (OCT) features in patients with diabetic macular edema (DME). This cross-sectional study included 100 eyes of 100 patients with type 2 diabetes mellitus. The systemic fluid status was assessed using extracellular water-to-total body water ratio (ECW/TBW) and phase angle (PhA), which was measured using bioimpedance equipment. ECW/TBW was higher in the DR (diabetic retinopathy) with DME group than in the no DR and DR without DME groups (p = 0.007 and p = 0.047, respectively); however, no significant difference was observed between the no DR and DR without DME groups. The PhA values were significantly lower in the DR with DME group (5.45 ± 0.84) than in the no DR (6.69 ± 0.69) and DR without DME groups (6.05 ± 1.15) (p < 0.001, p = 0.032, respectively). The presence of multiple HRF (hyper-reflective foci) was associated with a significantly higher ECW/TBW (p = 0.001). In the group with the most significant HRF, PhA was lower than in those with none or moderate amounts of HRF (p < 0.05). Bioimpedance fluid profiles of patients with OCT features of DME suggest a connection between the overall systemic state, including fluid status and DME development. Further research is required to fully understand and utilize this information for effective clinical assessment and treatment planning.
A Robust Denoised Algorithm Based on Hessian–Sparse Deconvolution for Passive Underwater Acoustic Detection
Authors: Yin Fan , Li Chao , Wang Haibin , Zhou Shihong , Nie Leixin , Zhang Yonglin , Yin Hao
Published: October 2023

Digital beamforming techniques find wide applications in the field of underwater acoustic array signal processing. However, their azimuthal resolution has long been constrained by the Rayleigh limit, consequently limiting their detection performance. In this paper, we propose a novel two-dimensional Hessian–sparse deconvolution algorithm based on image processing techniques. This method assumes a priori that the underwater acoustic bearing time record (BTR) images exhibit sparsity, and then it first constructs partial differential equations in the beamforming domain with sparsity-norm constraints for optimal noise reduction. Subsequently, a two-dimensional deconvolution operation is applied to narrow the main lobe, aiming to achieve additional temporal gains in two-dimensional processing. The simulation and real sea trial data processing results show that the main lobe width of the proposed method is about 1.3 degrees at 0 dB. It effectively reduces the main lobe width and enhances the detection resolution of BTRs in the post-processing part, especially in low-signal-to-noise-ratio (SNR) environments. Therefore, the proposed method provides nice opportunities to further improve the target-detecting ability of hydrophone arrays.
Underestimations in the In Silico-Predicted Toxicities of V-Agents
Authors: Pampalakis Georgios
Published: October 2023

V-agents are exceedingly toxic nerve agents. Recently, it was highlighted that V-agents constitute a diverse subclass of compounds with most of them not extensively studied. Although chemical weapons have been banned under the Chemical Weapons Convention (CWC), there is an increased concern for chemical terrorism. Thus, it is important to understand their properties and toxicities, especially since some of these agents are not included in the CWC list. Nonetheless, to achieve this goal, the testing of a huge number of compounds is needed. Alternatively, in silico toxicology offers a great advantage for the rapid assessment of toxic compounds. Here, various in silico tools (TEST, VEGA, pkCSM ProTox-II) were used to estimate the acute oral toxicity (LD50) of different V-agents and compare them with experimental values. These programs underestimated the toxicity of V-agents, and certain V-agents were estimated to be relatively non-toxic. TEST was also used to estimate the physical properties and found to provide good approximations for densities, surface tensions and vapor pressures but not for viscosities. Thus, attention should be paid when interpreting and estimating the toxicities of V-agents in silico, and it is necessary to conduct future detailed experiments to understand their properties and develop effective countermeasures.
Assessment of Surgical Accuracy in Maxillomandibular Advancement Surgery for Obstructive Sleep Apnea: A Preliminary Analysis
Authors: Ho Jean-Pierre T. F. , Zhou Ning , van Riet Tom C. T. , Schreurs Ruud , Becking Alfred G. , de Lange Jan
Published: October 2023

This retrospective study aimed to: (1) investigate the surgical accuracy of maxillomandibular advancement (MMA) in obstructive sleep apnea (OSA) patients, with a specific focus on maxillary and mandibular advancement and counter-clockwise rotation and (2) investigate the correlation between the amount of achieved advancement and the reduction in the relative apnea hypopnea index (AHI). Sixteen patients, for whom a three-dimensional virtual surgical plan was generated preoperatively and a computed tomography scan (CT) or cone-beam computer tomography (CBCT) was acquired postoperatively, were included. The postoperative CT or CBCT was compared to the virtual surgical plan, and differences in the mandibular and maxillary advancement and counter-clockwise rotation were assessed. Maxillary and mandibular advancement (median 3.1 mm, p = 0.002 and 2.3 mm, p = 0.03, respectively) and counter-clockwise rotation (median 3.7°, p = 0.006 and 4.7°, p = 0.001, respectively) were notably less than intended. A significant correlation was found between the planned maxillary advancement and the difference between the planned and actual maxillary advancement (p = 0.048; adjusted R2 = 0.1979) and also between the planned counter-clockwise rotation and the difference between the planned and actual counter-clockwise rotation for the mandible (p = 0.012; adjusted R2 = 0.3261). Neither the maxilla-first nor the mandible-first surgical sequence proved to be superior in terms of the ability to achieve the intended movements (p > 0.45). Despite a significant reduction (p = 0.001) in the apnea hypopnea index (AHI) from a median of 62.6 events/h to 19.4 events/h following MMA, no relationship was found between the extent of maxillary or mandibular advancement and AHI improvement in this small cohort (p = 0.389 and p = 0.387, respectively). This study underlines the necessity for surgeons and future research projects to be aware of surgical inaccuracies in MMA procedures for OSA patients. Additionally, further research is required to investigate if sufficient advancement is an important factor associated with MMA treatment outcome.
Earnings Management and Status of Corporate Governance under Different Levels of Corruption—An Empirical Analysis in European Countries
Authors: Dokas Ioannis
Published: October 2023

This study investigates the effect of the characteristics of the board of directors on the accrual and real earnings management level, focusing on the role of the corruption level. The employed dataset consists of 469 European-listed firms from 2011 to 2019. Using a fixed-effect panel data regression model, the results documented that larger boards lack coordination and communication in less corrupt economies, facilitating earnings manipulation through accruals and sales. In highly corrupt countries, oversized boards are associated with increased manipulation of production costs and discretionary expenses. Board meetings are positively related to accrual and sales manipulation in low-corruption countries, and board independence leads to reducing discretionary expenses regardless of corruption level. Board tenure negatively affects accruals and discretionary expenses but tends to increase manipulation through production costs in low-corruption contexts. Additionally, when the CEO serves as the board chairman, it encourages the manipulation of discretionary expenses while reducing real earnings manipulation through sales and production costs. In aggregate, the level of corruption can influence a board’s effectiveness under specific conditions.
Environmental Performance and a Nation’s Growth: Does the Economic Status and Style of Governance of a Country Matter?
Authors: Rastogi Shailesh , Kanoujiya Jagjeevan , Tejasmayee Pracheta , Banerjee Souvik , Parashar Neha , Dani Asmita
Published: October 2023

The literature abounds with studies on the impact of the growth of nations on the environment. However, studies on the financial materiality of environmental concerns are found less often. This study aims to determine the impact of environmental concerns on a nation’s GDP per capita (GDPC). In addition, the influence of developed nations and democracy is also explored. The data for 106 countries and ten years (2011–2020) are procured from World Bank’s official website. The countries with incomplete data for a balanced panel are not included. Panel data econometrics (quantile regression) is applied to analyze the data. Environmental concerns are measured with the help of environmental efficiency (EE) using data envelopment analysis (DEA). It is found that environmental efficiency (EE) negatively impacts the GDPC for low levels of GDPC. However, no association of EE with GDPC is witnessed in the case of high GDPC levels. In addition, developed nations positively moderate the EE’s impact on the GDPC when the GDPC levels are high. Moreover, democratic nations negatively moderate the EE’s impact on the GDPC when low GDPC levels exist. The main implication of the current study is that developed high GDPC countries could bear a significant chunk of the cost of EE. This way, the adverse impact of an increase in EE on the GDPC (by low GDPC counties) could be dodged, and by the efforts of developed high GDPC countries, EE could be increased significantly without adversely impacting their GDPC.
Agricultural Land Rights Confirmation, Clan Network, and Farmers’ Investment in Production and Operation
Authors: Hong Mingyong , Yu Shunfa , Long Jiao
Published: October 2023

This study is based on micro-survey data on rural household transfers in China. This study uses a multiple linear regression model (to analyze the relationship between variables), an instrumental variable model (to solve potential endogenous problems), and an intermediary effect model to explore the impact of farmland rights confirmation and clan network on farmers’ investment in production and operation and the relationship between clan network confirmation of farmland rights and farmer household investment. The research shows that: (1) The confirmation of farmland rights in China substantially bolsters farmers’ investments in agricultural production and operation. It serves as a secure foundation for land property rights, elevating farmers’ confidence and significantly contributing to the growth of rural economies and the improvement of farmers’ income levels in the Chinese context. (2) In the Chinese context, the existence of clan networks exerts a discernible adverse influence on farmers’ investment decisions in agricultural production and operation. This is primarily attributable to the restricted flow of information within these networks, the enforcement of stringent social norms, and the prevalence of risk-averse attitudes. These factors collectively act as barriers, dampening farmers’ enthusiasm for investment and impeding effective decision-making. (3) Importantly, the confirmation of agricultural land rights in China serves as a counterbalance to the inhibitory effects of clan networks. It achieves this by mitigating information asymmetry and reducing cooperation risks. This proactive approach not only promotes but also facilitates farmers’ investments in agricultural production and operation within the Chinese context. Consequently, land rights confirmation emerges as a key driver of increased rural investments in China. This study conducts in-depth research on the impact of farmland ownership confirmation and clan networks on farmers’ investment behavior and the mechanism of action, which provides a useful reference for formulating relevant policies, such as increasing the authority of cultivated land, promoting the modernization of clan networks, cultivating modern management capabilities, etc.
Trends in High Nature Value Farmland and Ecosystem Services Valuation: A Bibliometric Review
Authors: Girão Inês , Gomes Eduardo , Pereira Paulo , Rocha Jorge
Published: October 2023

High Nature Value farmland (HNVf) represents a rural landscape characterized by extensive farming practices. These lands not only deliver vital ecosystem services (ES) but also serve as significant harbors of biodiversity, underscoring their critical conservation status. Consequently, European Union countries have prioritized the identification, monitoring, and enhancement of HNVf systems in their policies. As governments and international organizations increasingly lean on green subsidies to promote sustainable environmental practices, the valuation of ecosystem services (VES) emerges as a crucial tool. This valuation offers both an economic rationale for conservation and aids in determining the optimal allocation of these subsidies for maximum environmental and economic return on investment. Given the potential for such valuations to shape and justify conservation subsidies, there is a growing imperative to understand the research trends and knowledge gaps in this realm. This article, through a bibliometric review, seeks to illuminate the size, growth trajectory, and thematic tendencies within HNVf and VES literature. Bibliometric analysis is recognized as promising in identifying research trends; thus, this article consists of a bibliometric review of HNVf and VES research. The objective is to identify the size, growth trajectory, and geographic distribution of HNVf and VES literature between the first publication until 2022, while assessing the critical publishing journals, authors, documents, and conceptual structure of the research fields (e.g., economic, social, and environmental). The analysis revealed a predominant concentration of research on HNVf in Europe, with limited studies conducted outside this continent. The primary focus of these studies revolved around subject areas such as environmental science, agriculture, and biological sciences. Conversely, regarding research on VES, there was no clear regional concentration. VES research publications mainly covered the interdisciplinary fields of economics, biology, and policymaking. As the fields of HNVf and VES have evolved, it is evident that there has been a stronger push towards data-driven approaches, emphasizing the need for tangible assessments and precise understanding. In examining the overlap between topics, the analysis revealed a gap between methodologies for HNVf monitoring and conservation and VES, highlighting the need for further development in crafting an integrated approach encompassing both areas.
Investigation of Mechanical Properties of Grey Cast Irons Reinforced with Carbon Titanium Nitride (TiNC)
Authors: Yakut Rifat
Published: October 2023

In this study, grey cast iron (GG25) was produced via reinforcement with carbon titanium nitride (TiNC) in different amounts (0%, 0.153%, 0.204% and 0.255%). Samples were made from this material according to the standards for hardness, compression and wear, and then experiments were conducted. The test conditions applied for the TiNC-reinforced samples were similarly applied to unreinforced samples. The TiNC-reinforced and unreinforced samples were compared regarding their compression, hardness, and wear properties. The results of the hardness tests showed the highest average hardness value of 215 HB for sample A (0% TiNC). For TiNC-reinforced specimens, the hardness values of the reinforced specimens increased with increasing reinforcement. Sample B (0.153% TiNC) had an average hardness value of 193 HB. For sample C (0.204% TiNC), an average hardness value of 200 HB was measured. For sample D (0.255% TiNC), an average hardness value of 204 HB was determined. Sample A’s highest compression strength value was 780 MPA (0% TiNC). Similar to the hardness test values, the compression strength of the reinforced samples increased with the increasing reinforcement rate. The compression test value was found to be 747 MPa for sample B (0.153% TiNC), 765 MPa for sample C (0.204% TiNC) and 778 MPa for sample D (0.255% TiNC). Wear tests were performed on all samples to examine changes in the wear volume loss, wear rate and friction coefficients. Scanning electron microscopy (SEM) was used to determine the wear mechanisms on the worn surfaces of the samples. When examining the wear condition of the samples with the same hardness value as a function of increasing load values, increases in the wear volume loss values were observed as the load value increased.
On Characterization of Shear Viscosity and Wall Slip for Concentrated Suspension Flows in Abrasive Flow Machining
Authors: Peng Can , Gao Hang , Wang Xuanping
Published: October 2023

In the realm of abrasive flow machining (AFM), precise finishing and maintaining dimensional accuracy have remained challenging due to non-uniformities in the AFM process and complexities associated with the abrasive media’s shear viscosity and wall slip behavior. By addressing these challenges, this study introduces a comprehensive framework, combining theoretical foundations, measurement techniques, and experimental setups. Utilizing capillary flow, a novel compensation strategy is incorporated within the Mooney method to counter entrance pressure drop effects. This enhanced capillary flow method emerges as a promising alternative to the conventional Cox–Merz empirical rule, enabling precise characterization of wall slip behavior and shear viscosity, particularly at elevated shear rates. The abrasive media exhibit a Navier nonlinear wall slip, as highlighted by the Mooney method. Rigorous verification of the proposed methodologies and models against supplemental experiments showcases a high degree of congruence between predicted and observed results, emphasizing their accuracy and broad application potential in AFM. This research illuminates the intricacies of the abrasive media’s behavior, accentuating the need for meticulous characterization, and provides a robust foundation for genuine modeling and predictions in material removal within AFM.
Implant-Supported Fixed Partial Dentures with Posterior Cantilevers: In Vitro Study of Mechanical Behavior
Authors: García-Sala Bonmatí Fernando , Bustamante-Hernández Naia , Alonso Pérez-Barquero Jorge , Maneiro-Lojo Jesús , Fons-Badal Carla , Labaig-Caturla Carla , Fernández-Estevan Lucía , Agustín-Panadero Rubén
Published: October 2023

Rehabilitation with dental implants is not always possible due to the lack of bone quality or quantity, in many cases due to bone atrophy or the morbidity of regenerative treatments. We find ourselves in situations of performing dental prostheses with cantilevers in order to rehabilitate our patients, thus simplifying the treatment. The aim of this study was to analyze the mechanical behavior of four types of fixed partial dentures with posterior cantilevers on two dental implants (convergent collar and transmucosal internal connection) through an in vitro study (compressive loading and cyclic loading). This study comprised four groups (n = 76): in Group 1, the prosthesis was screwed directly to the implant platform (DS; n = 19); in Group 2, the prosthesis was screwed to the telescopic interface on the implant head (INS; n = 19); in Group 3, the prosthesis was cemented to the telescopic abutment (INC; n = 19); and in Group 4, the prosthesis was cemented to the abutment (DC; n = 19). The sets were subjected to a cyclic loading test (80 N load for 240,000 cycles) and compressive loading test (100 KN load at a displacement rate of 0.5 mm/min), applying the load until failure occurred to any of the components at the abutment–prosthesis–implant interface. Subsequently, an optical microscopy analysis was performed to obtain more data on what had occurred in each group. Results: Group 1 (direct screw-retained prosthesis, DS) obtained the highest mean strength value of 663.5 ± 196.0 N. The other three groups were very homogeneous: 428.4 ± 63.1 N for Group 2 (INS), 486.7 ± 67.8 N for Group 3 (INC), and 458.9 ± 38.9 N for Group 4 (DC). The mean strength was significantly dependent on the type of connection (p < 0.001), and this difference was similar for all of the test conditions (cyclic and compressive loading) (p = 0.689). Implant-borne prostheses with convergent collars and transmucosal internal connections with posterior cantilevers screwed directly to the implant connection are a good solution in cases where implant placement cannot avoid extensions.
Assessment of Properties and Microstructure of Concrete with Cotton Textile Waste and Crushed Bricks
Authors: Saca Nastasia , Radu Lidia , Truşcă Roxana , Calotă Răzvan , Dobre Daniela , Năstase Ilinca
Published: October 2023

Cotton textile waste (CW) and crushed bricks (CB) are wastes generated by the textile and construction industries that cause adverse effects on the environment. This paper explores the effect of adding 1, 2, 5, and 10 wt.% of CW and CB, instead of natural sand under 1 mm (50 to 100 vol.%), on the properties of concrete. The study included the analysis of workability, density, water absorption, thermal conductivity, mechanical strengths, and electron microscopy. The results show that the presence of CW and CB increased the water required to obtain the same slump value as reference, R. Concretes with CW provided better performance in terms of density, water absorption (for 1 wt.%), and splitting strength (for 1 to 2 wt.%). The 28 days of compressive strength decreased with increasing CW (33.3 MPa for R and 26.9 MPa for 2 wt.% of CW). The partial substitution of sand decreased the workability and density and increased the mechanical strength of concrete. The presence of both CW and CB decreased workability, density, and mechanical strengths. Regarding the ability of concrete to transfer heat, the addition of CW and CB decreased the thermal conductivity value (e.g., 0.32 W/(m·K) for 1 wt.% of CW compared to 0.37 W/(m·K) for reference).
Effect of Modified Cow Dung Fibers on Strength and Autogenous Shrinkage of Alkali-Activated Slag Mortar
Authors: Li Kang , Yang Zhengxian , Yan Xueyuan , Xu Liying , Briseghella Bruno , Marano Giuseppe Carlo
Published: October 2023

Alkali-activated slag (AAS) presents a promising alternative to ordinary Portland cement due to its cost effectiveness, environmental friendliness, and satisfactory durability characteristics. In this paper, cow dung waste was recycled as a renewable natural cellulose fiber, modified with alkali, and then added to AAS mortar. The physico-chemical characteristics of raw and modified cow dung fibers were determined through Fourier transform infrared (FTIR), X-ray diffraction (XRD), and Scanning electron microscope (SEM). Investigations were conducted on the dispersion of cow dung fibers in the AAS matrix, as well as the flowability, strength, and autogenous shrinkage of AAS mortar with varying cow dung fiber contents. The results indicated that modified fiber has higher crystallinity and surface roughness. The ultrasonic method showed superior effectiveness compared to pre-mixing and after-mixing methods. Compared with raw cow dung fibers, modified fibers led to an increase of 11.3% and 36.3% of the 28 d flexural strength and compressive strength of the AAS mortar, respectively. The modified cow dung fibers had a more significant inhibition on autogenous shrinkage, and the addition of 2 wt% cow dung fibers reduced the 7 d autogenous shrinkage of the AAS paste by 52.8% due to the “internal curing effect.” This study provides an alternative value-added recycling option for cow dung fibers as a potential environmentally friendly and sustainable reinforcing raw material for cementitious materials, which can be used to develop low autogenous shrinkage green composites.
Peculiarities of the Structure of Au-TiO2 and Au-WO3 Plasmonic Nanocomposites
Authors: Sagidolda Yerulan , Yergaliyeva Saule , Tolepov Zhandos , Ismailova Guzal , Orynbay Bakytzhan , Nemkayeva Renata , Prikhodko Oleg , Peshaya Svetlana , Maksimova Suyumbika , Guseinov Nazim , Mukhametkarimov Yerzhan
Published: October 2023

As nanotechnology continues to advance, the study of nanocomposites and their unique properties is at the forefront of research. There are still various blank spots in understanding the behavior of such composite materials, especially regarding plasmonic effects like localized surface plasmon resonance (LSPR) which is essential for developing advanced nanotechnologies. In this work, we explore the structural properties of composite thin films consisting of oxide matrices and gold nanoparticles (Au NPs), which were prepared by radio-frequency magnetron sputtering. Titanium dioxide (TiO2) and tungsten trioxide (WO3) were chosen as the host matrices of the composites. Such composite thin films owing to the presence of Au NPs demonstrate the LSPR phenomenon in the visible region. It is shown, that spectroscopic study, in particular, Raman spectroscopy can reveal peculiar features of structures of such composite systems due to LSPR and photoluminescence (PL) of Au NPs in the visible spectrum. In particular, defect peaks of TiO2 (700–720 cm−1) or WO3 (935 cm−1) in Raman spectra can be clearly observed when the samples are illuminated with a 633 nm excitation laser. Excitation with 532 nm leads to a decrease in the intensity of the defect peak, which totally disappears at 473 nm excitation. Such dependences of the defect peaks on excitation laser wavelength are probably related to the polarization of the matrix’s defective regions close to the interface with gold NPs.
Microporous Block Copolymers Modified with Cu(II)-Coordinated Polyethylene Oxide-Substituted Silicas for Analytical Sensors
Authors: Davletbaeva Ilsiya M. , Li Ekaterina D. , Faizulina Zulfiya Z. , Sazonov Oleg O. , Mikhailov Oleg V. , Safiullin Karim R. , Davletbaev Ruslan S.
Published: October 2023

The influence of stable-to-self-condensation Cu(II)-coordinated polyoxyethylene-substituted silicas (ASiP-Cu-0.5) on the synthesis of microporous block copolymers (OBCs) whose structural feature is the existence of coplanar polyisocyanate blocks of acetal nature (O-polyisocyanates) and a flexible-chain component of amphiphilic nature was studied. The use of ASiP-Cu-0.5 increased the yield of O-polyisocyanate blocks and the microphase separation of OBC. The resulting OBCs turned out to be effective sorbents for the analytical reagents PAN and PHENAZO, which, being in the micropore cavity, interacted with copper(II) and magnesium ions. To reduce the thickness of the selective OBC layer ten-fold and simplify the technology for obtaining analytical test systems, polyethylene terephthalate was used as a substrate for applying OBC. It was found that the increased sensitivity of the resulting test systems was due to the fact that in thin reaction layers, the efficiency of the formation of O-polyisocyanate blocks noticeably increased.
Effect of Impaired B-Cell and CTL Functions on HIV-1 Dynamics
Authors: AlShamrani Noura H. , Halawani Reham H. , Elaiw Ahmed M.
Published: October 2023

This paper formulates and analyzes two mathematical models that describe the within-host dynamics of human immunodeficiency virus type 1 (HIV-1) with impairment of both cytotoxic T lymphocytes (CTLs) and B cells. Both viral transmission (VT) and cellular infection (CT) mechanisms are considered. The second model is a generalization of the first model that includes distributed time delays. For the two models, we establish the non-negativity and boundedness of the solutions, find the basic reproductive numbers, determine all possible steady states and establish the global asymptotic stability properties of all steady states by means of the Lyapunov method. We confirm the theoretical results by conducting numerical simulations. We conduct a sensitivity analysis to show the effect of the values of the parameters on the basic reproductive number. We discuss the results, showing that impaired B cells and CTLs, time delay and latent CT have significant effects on the HIV-1 dynamics.