bluuebunny/crossref_metadata_2025 huggingface dataset:
Treatment of post-coronary insomnia from the perspective of deficiency
Authors: DU YuNing , Wang EnLong
Published: March 2024

The widespread epidemic of Coronavirus disease 2019 (COVID-19) worldwide has had a tremendous impact on both human life and health. The mechanism and treatment of the post-COVID symptoms after acute infection in patients with the COVID-19 has become an important research content at present. Insomnia is one of the most common sequelae after COVID-19. Modern medicine believes that the pathogenesis of insomnia after COVID-19 is related to psychological factors, persistent inflammatory reaction and immune system disorder, etc. According to the theory of traditional Chinese medicine(TCM), after the patient was infected with COVID-19, he had a deficiency after a serious illness, which led to the insomnia that the human body's Rong Wei was out of harmony and the yin and yang were out of harmony, and differentiate between different types of evidence found that the patient mostly manifested Deficiency of both qi and yin syndrome, Syndrome of non-interaction between the heart and kidney, Heart-spleen deficiency syndrome, Pattern of qi deficiency of both heart and gallbladder, etc., so the treatment should be based on the thesis of “deficiency” and should make full use of the theoretical features of Chinese medicine, such as "Theory of developing appropriate treatment according to three types of disease causes" and "Strengthening healthy qi to eliminate pathogenic factors",to adjust the physique of the patient after a serious illness, and at the same time take care of the spleen and stomach, so as to prevent the symptoms from recurring and to help the patient to restore his health as soon as possible.
Causal Inference and Genome-Wide Perturb-Seq Reveals Tau as Downstream Biomarker but not Driver of Diseases
Authors: Huang Zhiyuan
Published: March 2024

Tau is a protein created by alternative splicing of the gene MAPT, which plays an important role in stabilizing the internal structure of neurons. While Tau has been strongly associated with neurodegenerative diseases like Multiple Sclerosis (MS) and Alzheimer's disease, it remains unclear whether Tau is the cause of these diseases or merely a downstream biomarker. To investigate the causal association between MS and Tau levels, a Mendelian randomization (MR) analysis was performed and the results indicated that MS can causally elevate blood Tau expression. Specifically, for every one log-odds increase in MS risk, blood MAPT expression increases by 0.063 standard deviations. However, the reverse MR analysis did not show any evidence suggesting that increased blood Tau levels doesn’t affect the risk of developing MS. To gain further insights into the regulatory mechanisms of Tau and its relationship with neurodegenerative disease, we utilized Perturb-seq, a single-cell sequencing method that enables the mapping of transcriptional effects resulting from genetic perturbations. Though analyzing the transcriptomic data from genome-wide knockouts in a human cell line, it turned out that MAPT knock-out has relatively small transcriptomic impact. We also identified that genes regulating Tau, but not genes regulated by Tau, are enriched with neurodegenerative disease-related pathways. These findings suggest that Tau may serve as a downstream biomarker rather than an initiator of neurodegenerative disease, implying that future gene-based interventions should focus primarily on the upstream regulators of Tau instead of targeting Tau itself.
Potential of Cytokines in the Management of Intervertebral Disc Degeneration
Authors: Yu Huiyang
Published: March 2024

The illness known as intervertebral disc degeneration (IDD) is characterized by discomfort in the intervertebral discs. The IDD is made up of the annulus fibrosus (AF) and nucleus pulposus (NP), which function as a joint and cushion for the spine. IDD can develop with ageing, which can cause the NP to herniate and cause pain. IDD patients experience detrimental effects on their quality of life and mental health in addition to their physical health. It also poses a critical economic burden on society as a whole. Imaging techniques used for the diagnosis are disc herniation, X-ray plain film, CT, and MRI are discussed as imaging modalities, with MRI being particularly useful for diagnosing disc herniation. Treatment approaches range from conservative methods to surgical intervention, related to the type of IDD. Nonsteroidal anti-inflammatory medications, rest, traction therapy, and physical therapy are examples of non-surgical therapies. Options for surgery include conventional open surgery, microsurgical lumbar discectomy, minimally invasive IVD removal surgery, and artificial IVD replacement surgery. Many studies are focused on the role of cytokines to explain the cause of IDD. And these cytokines can be classified as cell cycle inhibitor, proinflammatory factor and growth factor. The article highlights cell cycle inhibitors (p16INK4a and p53), proinflammatory factors (IL-1β and TNF-α), and growth factor (TGF-β) involvement in IDD. However, currently, there are no cytokine-based treatments available for IDD in clinical practice. Future research could focus on developing new treatment or prevention targets for IL-1β or TNF-α.
Health Benefits of Tea Polyphenols and Mechanisms via Regulating Gut Microbiota
Authors: Xu Xinyue
Published: March 2024

Tea has been a beloved beverage for centuries, enjoyed by people all over the world. Tea polyphenols, natural bioactive compounds abundant in tea, have gained increasing attention for their potential health-promoting properties. This study provides a comprehensive overview of the multifaceted interactions between tea polyphenols and gut microbiota, shedding light on their roles in health and disease prevention. The opening section provides an in-depth examination of the definition and categorization of tea polyphenols, and their prevalence in various types of tea. Subsequently, the following section conducts an extensive analysis of the crucial role played by gut microbiota and the ways in which tea polyphenols modulate their composition, including their potential as prebiotic agents. In addition, this paper discusses the diverse health-promoting aspects of tea polyphenols, such as their antioxidative properties, anti-inflammatory effects, and their potential impact on conditions like inflammatory bowel diseases (IBD) and colorectal cancer, furthermore, explores their role in addressing functional disorders like depression and combating fatigue. This paper highlights the intricate interplay between tea polyphenols and gut microbiota and underscores the potential significance of these interactions in promoting health, advancing the understanding of the role of tea polyphenols in wellness and disease prevention.
The relationship and relevant factors between sleep disturbance and depressive symptoms in adolescents
Authors: Yin Xi
Published: March 2024

Depression and sleep difficulties have a strong association. Depression may coexist with long-term sleep difficulties in some people, and vice versa for those who already have depression, they are more likely to develop sleep disturbance. In other words, the development of one symptom can trigger the development of another. Patients must therefore pay close attention to their sleep difficulties. Numerous psychiatric illnesses that are related to sleep difficulties might worsen a patient's overall condition. If the issue of sleep difficulties is not resolved in a timely manner, it may eventually lead to the appearance of other connected psychiatric illnesses, which may make the patient's condition worse overall. Depression is a prevalent mental illness. Clinical symptoms of depression commonly include tiredness, delayed thinking, and diminished volitional activity. Sleep disturbances can arise for a variety of reasons, including physical illnesses and psychological issues. This review can provide some suggestions for the development of prevention and intervention programs for individuals with depression and sleep disturbance.
Systematic Overview: AD Pathology and Recent Pharmacological Advances
Authors: Luo Tingxi
Published: March 2024

This systematic review provides a comprehensive analysis of Alzheimer’s Disease (AD) pathology and its pharmacological advancements. Population aging over last decades render AD becoming more prevalent, indicating a significant sociological and economic burden. Yet, due to the complexity of the brain structure, the researchers must understand AD’s multifactorial pathology and progression mechanisms in order to find an effective treatment. The review will primarily examine the classical amyloid-β hypothesis and tau protein’s involvement, exploring their interplay in neuronal degeneration. Additionally, it also examines the emerging theories of neuroinflammation, prion-like proteins and vascular damages as crucial contributors to AD pathology. Recently, several FDA-approved non-curative drugs have been reported to reduce amyloid-β plaque and/or enhance cognitive function. Consequently, beyond analyzing AD’s pathological hypotheses, critically assessments on recent pharmacological advances using monoclonal antibodies (Aducanumab), cholinesterase inhibitors (Donepezil) and NMDA antagonists (Memantine) are used as examples to compare their clinical efficacies and controversies. Discussion on other factors including ethical considerations, personalized medicine and the transformation of treatment paradigms are included. By identifying a paradigm shift towards a multi-targeted approach which integrates pharmacological and non-pharmacological interventions, this review underscores the necessities of ethical concerns and patient-centred treatments. Thus, this review aims to present an academic consolidation of current knowledge and stimulate further interdisciplinary research, promoting innovation in AD treatment.
Seed-Induced Accumulation of β-Amyloid Exacerbates Oxidative Stress in Drosophila
Authors: Li Zhaotian
Published: March 2024

Background: Progression of Alzheimer's disease (AD) was considered involving fibrosis and amyloidosis of abnormal proteins that kill cells and disrupt neuronal connections. The polymerization process of Amyloid β (Aβ) is resistant to degradation. Aβ42, one of the major isoforms of Aβ, could be a "seed" to accelerate the aggregation and deposition of homologous or heterologous erroneous proteins in the brain. Methods: A new drosophila model was constructed by exogenous injection of Aβ42 to explore the neural mechanism of amyloid plaque formation in the brain. Results: Aβ aggregates in the brains of APP-injected flies decreased in the early stage and increased in the later stage, suggesting that Aβ42 may act as an innate immune defense molecule to activate brain immune responses to protect the host from infection. To demonstrate the effect of exogenous injections on antioxidant capacity, reactive oxygen species (ROS) were measured in a drosophila model. It was found that injection of Aβ42 accelerated ROS accumulation in the brain only in the short term, but ROS accumulated and accelerated Aβ accumulation in brain-induced neurodegeneration over time. Both crawling ability tests and lifespan tests showed more severe AD symptoms. However, in the monitoring of fly sleep after Aβ42 injection, sleep was compensated in APP flies injected with Aβ42. Conclusion: A seed mechanism is involved in the propagation and development of Aβ in the brain of Drosophila. It also provides new insights into Alzheimer's disease research.
Alkylammonium Modified Photosensitizers Achieve Lysosome-Precision Photodynamic Therapy: Implications from Molecular Dynamics Simulations
Authors: He Xi
Published: March 2024

Photodynamic therapy (PDT) is one of the developing treatment modalities that has been clinically approved for cancer treatment. It uses an organic photosensitizer that harnesses the light energy and converts intracellular oxygens to reactive cytotoxic species. The resulting chemicals can then damage cells and lead to cancer cell death. However, the existing photosensitizers do not show cancel cell or organelle specificity, which lowers their treatment outcomes. In this project, we used molecular dynamic simulations to demonstrate that a straightforward alkylammonium modification on photosensitizers is able to endow conventional photosensitizers with the ability to target and accumulate in lysosomes. This acquired lysosome specificity may achieve the lysosome-precision PDT experimentally, which is expected to enhance the PDT outcomes. More importantly, such organelle-precision modifications have the potential to be extended beyond PDT treatment and make contribution to drug discovery and eventually cancer treatment.
Application of enzyme-linked immunosorbent assay in cancer detection
Authors: She Zhen
Published: March 2024

The enzyme-linked immunosorbent assay (ELISA) has emerged as an indispensable method in the realm of cancer detection., serving as a significant factor in the timely identification, prediction, and surveillance of many forms of cancer. ELISA as a highly sensitive immunological assay, utilizes the binding affinity between antibodies and antigens to detect and quantify cancer-associated biomolecules, such as tumor markers, oncogenic proteins, and specific antibodies. The recently adopted methodology facilitates the identification of cancer-associated biomarkers in various types of samples, such as plasma, urine, and tissue extracts. In the context of cancer diagnosis, ELISA aids in the early detection of malignancies by detecting cancer-specific biomarkers at low concentrations, allowing for timely intervention and improved patient outcomes. This research provides a concise overview of the multifaceted applications of ELISA in the field of oncology, especially in electrochemical ELISA and gold nanoparticle–based ELISA. It discusses the diverse biomarkers employed, and elucidates its significance in cancer research and clinical practice.
The Health Regulatory Effect of Lactic Acid Bacteria on Human Body
Authors: Guan Yichen
Published: March 2024

Probiotics are a kind of active microorganisms that are beneficial to the host by colonizing in the human body and changing the composition of the flora in a certain part of the host. The organic acids, special enzymes and actinomycin’s produced by lactic acid bacteria (LAB) have special physiological functions. LAB can regulate the normal flora of gastrointestinal tract and maintain the microecological balance, so as to improve gastrointestinal function, increase food digestibility and biotiter, reduce serum cholesterol, control endotoxin, inhibit the growth of spoilage bacteria in intestinal tract, and improve body immunity. This paper studied the existence mode and influencing factors of probiotics and took LAB as an example to mainly describe the research progress of LAB in probiotics, discussed the mechanism of probiotics to maintain the ecological balance of intestinal flora, summarized the impact of probiotics on human body, and aimed at various problems and deficiencies faced by the probiotic industry at present. Some suggestions on the future research direction are put forward.
Analisis Filosofis Penerapan Moderasi Keberagamaan di Pondok Pesantren Islam Al-Mukmin Ngruki
Authors: Fanani Zahrodin
Published: March 2024

Artikel ini bertujuan untuk menganalisis filosofis Implementasi Moderasi Beragama di Pondok Pesantren Islam Al Mukmin Ngruki Sukoharjo jawa Tengah. Berdasarkan analisis penulis pada proses Pendidikan formal dan non formal di pesantren Ngruki, dapat dipahami bahwa Pondok Ngruki telah menerapkan Moderasi keberagamaan kepada santri dan santriwati. Dukungan dari pengasuh dan para ustdaz, juga merupakan salah satu efek dari bukti keterlibatan aktif keluarga pesantren untuk menerapkan moderasi beragama di tingkat santri.

Penulis menyimpulkan bahwa moderasi keberagamaan telah diterapkannya di pondok ngruki baik melalui kurikulum intrakurikuler maupun ekstrakurikuler, yang berarti dalam hal ini secara filosofis civitas akademika pondok pesantren Ngruki adalah civitas akademik yang moderat dalam keberagamaan. Namun peneliti juga menyarankan usaha yang perlu dikembangkan lebih lanjut adalah pengembangan mata pelajaran Agama Islam menjadi instrumen untuk mendiseminasi moderasi beragama salah satunya melakukan pengembangan moderasi beragama melalui Bahan Ajar.
A study of the relationship between the Russian and global stock markets in 2019-2024 using the DCC GARCH method
Authors: Айвазян Г.В.
Published: March 2024

В данном исследовании был проведен анализ зависимости между российскими (РТС, индекс МосБиржи) и мировыми (промышленный индекс Доу Джонса, S&P 500) фондовыми индексами в период с марта 2019 года по март 2024 года. Актуальность работы обусловлена резким изменением геополитической ситуации в последние два года и связанным с этим изменением конъюнктуры российского финансового рынка, что, полезно учитывать многим экономическим субъектам при принятии решений как, например, инвесторам при принятии инвестиционных решений. Для моделирования корреляции между индексами во времени была использована модель DCC GARCH первого порядка. В работе основной акцент был сделан на изучении связи между российскими и мировыми фондовыми рынками до и после 2022 года в контексте ужесточения антироссийских санкций. В результате анализа было обнаружено снижение корреляции между рассмотренными российскими и мировыми фондовыми индексами до небольших значений после 2022 года. Итоги исследования позволяют сделать вывод о значительном усилении изоляции российской экономики и финансового рынка в условиях санкций

This study analyzed the relationship between Russian (RTS, Moscow Exchange Index) and global (Dow Jones Industrial Index, S&P 500) stock indices in the period from March 2019 to March 2024. The relevance of the work is due to the sharp change in the geopolitical situation in the last two years and the related change in the conjuncture of the Russian stock market, which is useful for many economic entities to take into account when making decisions, such as investors when making investment decisions. The first-order DCC GARCH model was used to model the correlation between indices over time. The main focus of the work was on studying the relationship between Russian and global stock markets before and after 2022 in the context of tightening anti-Russian sanctions. The analysis revealed a decrease in the correlation between the considered Russian and global stock indices to insignificant values after 2022. The results of the study allow us to conclude that the isolation of the Russian economy and financial market has significantly increased under the conditions of sanctions
Ethical AI Governance: A Global Blueprint
Authors: Pasupuleti Murali Krishna
Published: March 2024

Abstract: In an era where artificial intelligence (AI) significantly impacts societal norms, economic structures, and individual rights, establishing a framework for ethical AI governance emerges as a paramount concern. "Ethical AI Governance: A Global Blueprint" provides a comprehensive exploration of the principles, challenges, and strategies necessary for implementing ethical governance of AI technologies across the globe. This chapter delves into the universally recognized principles of fairness, accountability, transparency, and privacy, examining their application in diverse cultural and legal contexts. It highlights the global challenges and opportunities in harmonizing ethical AI governance, emphasizing the need for international cooperation, stakeholder engagement, and the development of adaptable regulatory mechanisms. Through a review of existing frameworks and models, along with case studies of successful implementations, the chapter offers a detailed blueprint for ethical AI governance. This blueprint advocates for collaborative platforms, educational initiatives, and robust monitoring and evaluation mechanisms to ensure AI's ethical development and deployment. As AI continues to evolve, this chapter serves as a foundational guide for stakeholders worldwide to navigate the complex landscape of ethical AI governance, fostering innovation that aligns with human values and societal norms. Keywords/Index Terms: Artificial Intelligence (AI),Ethical Governance,Global Blueprint,Fairness,Accountability,Transparency,Privacy,International Cooperation,Regulatory Mechanisms,Stakeholder Engagement,Education and Awareness,Monitoring and Evaluation,Cultural Diversity,Legal Variances,Economic Disparities,Frameworks and Models,Case Studies and Innovation Ecosystems.
Entornos virtuales de aprendizaje: un espacio para fomentar el aprendizaje ante la presencia del COVID-19
Authors: Suárez Martínez Kaufa
Published: March 2024

The general purpose of this article is to interpret the perception of university actors about learning experiences during the use of Virtual Learning Spaces in the National Training Program (PNF) in Hydrocarbons of the Territorial Polytechnic University of Zulia (UPTZ) before the COVID-19 pandemic. Oriented on the qualitative research approach, under the interpretive paradigm, the chosen method is phenomenological. Four (04) teachers and four (04) students were considered as actors in the study. The data collection technique was the in-depth interview. The techniques used are demonstrated through the reliability and validity of the key informants, these are reinforced by the categorization of the information. The findings were made known, the lack of knowledge about the use of EVA could lead to a lack of student learning in times of the COVID-19 pandemic, which had some negative consequences. It is concluded that there were not very positive teaching experiences during the pandemic, specifically regarding evaluation, because a greater diversity of ways of evaluating was reported.
Experiencias estudiantiles durante la pandemia por covid-19: una mirada al aprendizaje colaborativo en línea
Authors: Suárez Martínez Karina
Published: March 2024

The purpose of this article is to describe student experiences during the COVID-19 pandemic and collaborative online learning in the National Electricity Training Program of the Territorial Polytechnic University of Zulia. As for the methodology, it was under the qualitative approach, the interpretive paradigm and the method was phenomenological. Three students and three teachers were considered. The data collection technique was the unstructured interview and the instrument was the script; reliability and external reliability were determined because a reality was studied in different times or situations. The results indicate that online learning is the way forward because it allows the flexibility and comfort of doing extra activities in real time. It is concluded that the COVID-19 pandemic caused a significant disruption at UPTZ, forcing students to make a complete transition to online learning and teachers to quickly adopt new technologies and resources to teach in new ways.
Propuesta de rediseño curricular para la carrera de Derecho, mediante la formación basada en competencias
Authors: Prudencio Candia Paola Verónica
Published: March 2024

The objective of this study was to propose the curricular redesign of the “San Agustín” Law degree, through competency-based training, in response to the demands, social needs and expectations of professional training, in correspondence with the development of legal sciences. from the Technical University of Oruro, Bolivia. The type of research was descriptive-exploratory and propositional, with a non-experimental and transactional design. The results indicated that 52% of those surveyed endorse the current curriculum as excellent and good. It is concluded that the curricular redesign of the study plan, of the Law degree, is achieved through competency-based training, based on the study and analysis of the “quality” element in the graduates, to identify the difficulties and problems that they face, contrasting them with the study profile, in order to determine that the current study plan does not meet the current challenges.
Diagnóstico de necesidades psicopedagógicas mediante la atención clínica y grupal en la Universidad Adventista, Bolivia
Authors: Merida Choquez Katerine Elizabeth
Published: March 2024

The results of the diagnosis of the main psycho-pedagogical needs of university students and school-age children with and without learning difficulties are shown. The sample was made up of 400 university students, five managers, 20 teachers, 24 children and seven university students who attended the psycho-pedagogical office. The survey, interview, test and questionnaire were used as instruments. It is found that there is agreement in the preference for using real or imaginary examples as strategies; Students consider that the evaluation should not have ambiguous questions, the preferred teaching methodology is questioning and exposition, while teachers consider narration about their work experience. The students propose as a psycho-pedagogical need to improve comprehension and increase reading speed, to have oratory techniques, effective performance in front of the public and study techniques. The teachers indicated that it is necessary to strengthen writing and written production.
Modalidad virtual como estrategia didáctica para el proceso de enseñanza-aprendizaje en la carrera de Derecho
Authors: Quiñones Ortiz Shirley Roxana
Published: March 2024

In this study, the technological, methodological, motivational and cognitive availability was analyzed to implement a virtual course as a teaching strategy in the teaching-learning process in the Law degree. A propositional-descriptive study was carried out, showing that 87.5% of students consider it positive to use technologies to learn, while 52.1% claim to make good use of them. Regarding the use of technologies by the teacher, 50% rate it as low for presentations in class and 54.2% for evaluation. Furthermore, 56.3% consider that the teacher has little technological mastery. However, 64.6% of students consider that it would be beneficial to implement a change in teaching-learning methodology. The teacher recognizes his pedagogical and technological skills, and is willing to assume a virtual teaching model. As a result of this study, a virtual course on Procedural Law, Judicial Branch Law and Notarial Law was designed in the Law degree, using the Moodle platform, with the aim of improving academic efficiency.
Educación en valores a estudiantes de derecho, pilar indispensable para el ejercicio profesional
Authors: Chavarria Campos Patricia Susana
Published: March 2024

The objective of this research is to reflect on the relevance that the formation of values in law students at the Tomas Frías Autonomous University in Bolivia has for the practice of the profession. The research was developed under a mixed approach (quantitative-qualitative), with a survey of 100 schoolchildren from the first and second year of the aforementioned degree and a structured interview with 10 teachers. The main results highlight that students recognize that higher education contributes to human and social development. The teachers agreed that education in values is a systemic, multidimensional, intentional and integrated process that is realized through the curricular and extracurricular. It is concluded that it is pertinent for the students of this science so that when they practice they comply not only with the social commitment to administer justice and do so with responsibility and suitability, but also that they are, among other things, honest, supportive, respectful and humble; attached to the social, moral and legal norms established by society.
Melodien erfinden mit authentischen Aufgaben - Der Einfluss von Aufgabeninstruktionen auf Gruppenkompositionen
Authors: Büring Markus
Published: March 2024

Konstruktivistische Lernkonzepte wie das Problembasierte Lernen fordern als Konsequenz komplexe, authentische Aufgaben in offenen Lernarrangements. Die Entwicklung authentischer Aufgaben im Musikunterricht könnte eine neue musikdidaktische Perspektive bieten, die Ã¤sthetische Erfahrungen und fächerübergeifendes bzw. integrierendes Wissensmanagement gleichermaßen zulässt. Es wird ein Aufgabenmodell nach dem Vorbild der Anchored Instruction zur Melodieerfindung in Kleingruppen vorgestellt, bestehend aus Ankergeschichte, Aufgaben(set) und ergänzenden Materialien. Mit der Ankergeschichte soll eine problembasierte, authentische Lernsituation generiert werden, deren Offenheit mit instruktionaler Unterstützung stark eingeschränkt werden kann. Die Kombination aus Aufgabeninstruktion und versteckten Lernhilfen in den ergänzenden Materialien soll die kognitive Informationsverarbeitung der Probanden steuern sowie den gesamten Problemlöseprozess in Teilen beschleunigen. Im folgenden Beitrag wird die Wirksamkeit dieser aufgabenorientierten Problemlöseprozesse auf die Qualität von zweiminütigen Schülerkompositionen ausgewertet.

Die Ergebnisse der analysierten Kurzzeiteffekte mit 13- bis 15-jährigen Schülerinnen und Schülern zeigen, dass in dem Versuchszeitraum von 45 Minuten die Steuerung des Lernprozesses durch direkte Instruktionen im Hinblick auf die Entdeckung des Variationsprinzips als Melodien generierender Mechanismus wirksamer sind als offene Instruktionen. Bei der Bearbeitung von Aufgaben mit offenen Instruktionen entstehen zwar originellere Kompositionen, die im Sinne der in der Aufgabe präsentierten Problemsituation aber nicht nachhaltig generierend wirken. Die Schüler entwickelten ihre Melodien mit diesem Aufgabentyp trotz der offenen Problemsituation nicht systemisch, sondern sukzessiv-additiv, was ihren präferierten Problemösestrategien aus bisherigen Unterrichtserfahrungen entsprach.
Daniela Neuhaus (2008). Perspektive Musiklehrer/in. Der Berufswahlprozess von Lehramtsstudierenden mit dem Unterrichtsfach Musik.
Authors: Bailer Noraldine
Published: March 2024

Köln: Verlag Dohr. ISBN 978-3-936655-57-5. 39,80 €.
Der Capability Approach in der musikpädagogischen Teilhabeforschung. Empirische Anwendung eines capability-basierten Modells der Teilhabe an Musikkultur.
Authors: Krupp-Schleußner Valerie
Published: March 2024

Das Entstehen zahlreicher musikalischer Bildungsangebote legitimiert sich nicht selten aus der Forderung nach mehr Teilhabegerechtigkeit. „Jedem Kind ein Instrument“ ist hierfür ein Beispiel. Der Artikel widmet sich der Entwicklung und Anwendung eines Modells der Teilhabe an Musikkultur auf der Basis des Capability Approach. In diesem auf das Individuum fokussierten Rahmen werden das domänenspezifische und das allgemeine well-being (i. S. von Lebenszufriedenheit) als individuelle Indikatoren für das Gelingen der Teilhabe an Musikkultur und für die Beurteilung von Teilhabegerechtigkeit einbezogen.Die empirische Anwendung des Modells erfolgt im Rahmen einer Analyse der Teilhabe an Musikkultur in Klassenstufe 7. Es kann gezeigt werden, dass sich auf der Basis von domänenspezifischem well-being und der Teilhabe an Musikkultur vier unterschiedliche Teilhabeprofile bilden lassen. Teilhaben und nicht-teilhaben nicht als einfache Dichotomie zu betrachten. Insgesamt können wichtige inhaltliche Annahmen des Teilhabe-Modells bestätigt werden, was die Produktivität des Capability Approach für die musikpädagogische Teilhabeforschung bestätigt.Schlagwörter: JeKi, Capability Approach, kulturelle Teilhabe, Teilhabegerechtigkeit, well-being
Lernstrategien beim musikalischen Üben handlungsnah erfassen
Authors: Naujoks Nick , Weiß Simone , Händel Marion
Published: March 2024

Das Üben spielt eine zentrale Rolle beim Musizieren. Gelingende Übeprozesse sind durch einen vielfältigen Einsatz verschiedener Lernstrategien gekennzeichnet. Ziel dieser Arbeit war es, das selbstregulierte Lernverhalten während des individuellen Übens anhand verwendeter Lernstrategien zu erfassen. Dazu wurden Video-Stimulated-Recall Interviews mit sechs Musiker*innen unterschiedlichen Alters und mit unterschiedlichen instrumentalen Vorkenntnissen durchgeführt. Eine qualitative Inhaltsanalyse der transkribierten Interviews mit Hilfe eines selbsterstellten Kodierleitfadens zeigte, dass durch die Video-Stimulated Recall Interviews als verwendete Forschungsmethode eine Vielzahl verschiedener Lernstrategien abgebildet werden konnte. Dabei zeigten sich sowohl zwischen den einzelnen Lernstrategien als auch in Abhängigkeit des Alters bzw. der Bildungsinstitution interindividuelle Unterschiede in der Häufigkeit des Strategiegebrauchs, die auf Zusammenhänge mit musikalischer Expertise hinweisen.
The Effect of a High Monosodium Glutamate Diet in Inducing Changes in Microbiota Diversity and Kidney Pathology in Hamsters Infected with Opisthorchis viverrini
Authors: Sarutipaiboon Ingkarat , Dangtakot Rungtiwa , Thunyaharn Sudaluck , Pinlaor Somchai , Haonon Ornuma
Published: March 2024

OBJECTIVE: To investigate the effect of a combination of a high dose of monosodium glutamate (MSG) and chronic Opisthorchis viverrini (O. viverrini) infection on kidney pathology and microbiota changes compared to either factor alone.METHODS: Forty male golden hamsters were divided into four groups (10 hamsters per group): non-infected hamsters fed with standard diet (NC), O. viverrini infected hamsters fed with standard diet (OV), non-infected hamsters fed with high doses of MSG in drinking water (MS), and O. viverrini infected hamsters fed with high doses of MSG in drinking water (OM). After 8 months, fecal samples were collected, DNA extracted and subjected to 16S-rRNA sequencing analysis to determine microbial diversity. Kidneys were also collected for histopathological study.RESULTS: Kidney histopathology showed tubular damages and tubular fibrosis were significantly prominent in the OM group, which showed higher pathology changes than in the OV group or MS groups. Next generation sequencing indicated that the levels of Firmicutes to Bacteroides ratio decreased in the OV group (0.28), MS group (0.43) and OM group (0.43) respectively when compared to control group (0.52). In genus levels, Methanobrevibacter, Ruminococcus_1, Escherichia Shigella, Bacteroides, Akkermansia and Oligella were abundance in the OM group.CONCLUSION: The changing of gut microbiota distribution and kidney pathology changes were more severe in the cases of O. viverrini infection together with MSG consumption. This study provides a first step towards focusing on diet and parasitic infections.
Ultrasound Percutaneous Tenotomy: An Intervention for Managing Lateral Epicondylitis: A Narrative Review
Authors: Suwannaphisit Sitthiphong , Thaveepunsan Sutee , Chaitantipongse Sirisak , Nakanishi Yasuaki
Published: March 2024

A growing emphasis is being focused on percutaneous ultrasonic tenotomy for expedited recovery from lateral epicondylitis (LE) and enhanced functionality. The TX1 tissue removal system, also known as the Tenex device from Tenex device (Tenex Health Inc., Lake Forest, CA, USA), notably excels in the management of chronic LE. Utilizing ultrasonic energy, this device offers three tips, namely, TX1, TX2, and TXBone-introducing novel avenues, for determining the previously inaccessible tendon pathology. The procedure disrupts degenerated segments, which creates fenestrations that induce local hemorrhage and the release of vasoactive substances. The overarching goal of Tenex is to boost vascularity through the initiation of tendon repair via the deposition of new collagen and elimination of necrotic tissues. This review assesses Tenex’s effectiveness though gathering information, aiming to understand how it helps doctors and other healthcare professionals in their work.
Implementation of Digital Business in Maximizing Small and Medium Enterprises During the Covid 19 Period
Authors: Aggy Pramana Gusman  , Ahmad Vajri Rahman
Published: March 2024

The SME products produced by the women's savings and loan cooperatives in Lubuk Basung, Agam Regency, West Sumatra are the majority of food products which are homemade on a home scale and are done by housewives. The growth and development of SMEs in the range of Maninjau Lake, Lubuk Basung, Agam Regency, especially those produced by housewives, has experienced various kinds of obstacles so that it is not optimal. Technology-based marketing strategies can be a major force to boost sales of these products. The purpose of this activity is to increase market share so as to increase turnover and profit from product sales through social media as a marketing tool for SME products. The number of participants was 47 people, consisting of housewives who were members of the cooperative. The method used is training and mentoring. The result of this training is an increase in the knowledge and ability of participants in the use of social media as a marketing tool, as indicated by a change in the average pretest and posttest scores, from a score of 71.03 to a score of 120.30. Participants' final understanding of social media Facebook is 70% greater than participants' final understanding of Instagram by 55%.
Implementation Of The Argonoleptic Test Of Purple Sweet Potatoes BasicBiscuits As A Processing Innovation Of Mp-Asi Ages 6 – 12 Months
Authors: Nita Tri Putri  , Vedjia Medhyna  , Anjali Shakila
Published: March 2024

This Community Service (PKM) aims to add insight and knowledge about the importance of writing scientific papers, techniques, and procedures for writing scientific publication articles, concepts, and techniques for publishing articles in national scientific journals, to the management of Scientific Publication Journals. Infancy is the most important period because it is a period that is very vulnerable to malnutrition. The provision of breast milk substitutes (MP-ASI) has an important role in overcoming the problem of malnutrition in infants. Purple sweet potatoes can help meet nutritional needs because they contain complex nutrients, namely carbohydrates, protein, fat, vitamins, iron, fiber, and anthocyanins. This type of research is an experiment that aims to determine the organoleptic test on biscuits substituted with purple sweet potato flour. The research population was mothers of infants aged 6-12 months and infants aged 6-12 months with a total population of 293 people. The sampling technique was purposive sampling with a total sample of 29 mothers of infants aged 6-12 months and 29 infants aged 6-12 months. The results of the organoleptic test showed that the level of preference for color was very like (38%) liked (55%) taste was very like (55%) liked (45%), the texture was very like (31%) liked (48%), the aroma was very like (34 %) liked (48%) and the acceptability test for 6-12 months babies liked it (93%). The results of this study can be useful as complementary foods for breast milk so that it can meet the daily nutritional needs of babies. It is recommended that further research be carried out to increase the preference value on the color, texture, and aroma of purple sweet potato biscuits
Dagusibu And Pkrt Health Counseling In The Surrounding EnvironmentFor Wkri Dpd West Sumatra
Authors: Reny Salim  , Tuty Taslim  , Irene Puspa Dewi  , Fita Selonni
Published: March 2024

Mothers need knowledge of the treatment and use of PKRT according to the rules. This is important considering that the mother is the individual responsible for taking care of the family's needs. The expert must welcome the fulfillment of these mothers' needs must be received through devotional activities. One form of service activity that mothers can do is health counselling which aims to measure the influence of counselling on changes in participants' attitudes. The participants in this counselling are the categorial group of WKRI DPD West Sumatra The method used is offline and online interactive counselling. The supporting media used are Microsoft PowerPoint, Quiziz, and Zoom. The data collection method used is pretest-posttest. The results obtained in the counseling activity were a change in participants' attitudes before and after counseling with a signification value of p<0.05. It means that there is a need for interactive counseling on drugs and PKRT that can help improve public health and lower long-term adverse risks.
PERAN MADRASAH DALAM MEMBENTUK KEHIDUPAN PENDIDIKAN HUMANIS, INKLUSIF, DAN RELIGIUS
Authors: Mentari Luluk Kurnia
Published: March 2024

Abstract: Madrasa is a place or educational institution to study Islamic knowledge, science, and other expertise in a directed, guided, and controlled manner. The approach used in this research is a qualitative approach techniques of using collection data, namely library technique. The results of the analysis show that madrasa have an important role, that is as an educational institution in advancing education and improving the quality of educational organizer that are humanistic, inclusive, and religious. Some things that can be done by the madrasa to achieve the role of madrasa in form the life of humanist, inclusive, and religious education as follows: 1) Madrasa prepares adequate facilities and infrastructure for the teaching and learning process; 2) Madrasas prepares of quality education organizeror human resources in appropriate with competencies; 3) Madrasa prepares curriculum, administration, extracurricular activities, and its management system are formulated and implemented for the benefit of students including ABK; 4) Madrasa must provide the conditions of class that are warm, friendly, accept diversity and respect differences; 5) Madrasa must be prepared to manage heterogeneous classes by applying curriculum and learning that is individualized; 6) The teacher must be implemented interactive learning.

     Madrasah merupakan tempat atau lembaga pendidikan untuk mempelajari ajaran Islam secara terarah, terpimpin, dan terkendali. Hasil penelitian kualitatif ini menemukan bahwa madrasah memiliki peranan yang penting yaitu sebagai lembaga pendidikan dalam memajukan pendidikan serta meningkatkan kualitas penyelenggara pendidikan yang bersifat humanis, inklusif, dan religius. Beberapa hal yang dapat dilakukan oleh pihak madrasah untuk mencapai peran madrasah dalam membentukkehidupan pendidikan humanis, inklusif, dan religius sebagai berikut : 1) Madrasah mempersiapkan sarana dan prasarana yang memadai untuk proses belajar mengajar; 2)Madrasah menyiapkan penyelenggara pendidikan atau SDM yang berkualitas sesuai dengan kompetensi; 3) Madrasah mempersiapkan kurikulum, administrasi, kegiatan ekstrakurikuler, serta sistem pengelolaannya dirumuskan dan dilaksanakan demi kepentingan peserta didik termasuk ABK; 4) Madrasah harus menyediakan kondisi kelas yang hangat, ramah, menerima keaneka-ragaman dan menghargai perbedaan; 5) Madrasah harus siap mengelola kelas yang heterogen dengan menerapkan kurikulum dan pembelajaran yang bersifat individual; 6) Guru harus menerapkan pembelajaran yang interaktif.
Penggunaan Aplikasi Quiziz dan Relevansinya dengan Rekognisi Pembelajaran Daring Matematika di MAN 1 Model Bojonegoro
Authors: Agustinayanti
Published: March 2024

Abstract: This study reveals online Mathematics learning in the MAN 1 Bojonegoro Model on the pandemic table. Data with descriptive quantitative retrieval to comprehensively describe the bold pinking problem of how it is analyzed to optimize through the Applique Quiz. Some of the learning problems of courage that were found were: 1) Weaknesses of teachers and rumpy participants in utilizing information technology in courageous learning, 2) Teachers and schools/madrasahs are limited by the distance in controlling the bell for development of play abilities, hash control the pink learning platform, 4) School / Madrasah has not controlled the platform has a unique platform as a medium for pink evaluation of lessons. The presence of Quiz applique as an efficient solution to solve all problems that are evaluative exercises. In addition to free access and free users, Quiz also has exclusive features in doing questions and has fish bait for teachers that can be used as a reference for the development of students' abilities. Interested meandering participants, interactive from the fun.

Abstrak: Penelitian ini mengungkap rekognisi pembelajaran Matematika secara online di MAN 1 Model Bojonegoro pada masa pandemi ini. Data dianalisis dengan pendekatan kualitatif deskriptif untuk menggambarkan secara komprehensif mengenai problem pembelajaran daring dan cara untuk mengoptimalkan melalui aplikasi Quiziz. Beberapa probelematika pembelajaran daring yang ditemukan adalah: 1) Kelemahan guru dan peserta didik memanfaatkan tekhnologi informasi pada pembelajaran daring, 2) Guru dan sekolah/Madrasah terbatasi oleh jarak dalam mengontrol perkembangan kemampuan pelajaran Matematika, 3) belum memiliki platform model latihan soal untuk mengevaluasi hasil pembelajaran, 4) Sekolah/Madrasah belum memiliki platform khusus sebagai mediai pembelajaran dan evaluasi. Kehadiran aplikasi Quiziz sebagai solusi efektif dan efisien untuk menyelesaikan segala problem yang bersifat latihan evaluatif. Selain free acces dan free user, Quiziz juga memiliki fitur yang lengkap dalam mengerjakan soal, dan memiliki umpan balik kepada guru yang dapat dijadikan rujukan pengetahuan perkembangan kemampuan peserta didik. Peserta didik merasa tertarik, menyenangkan dan interaktif.

 

DOI: https://doi.org/10.33399/edukasia.v2i1.38
Optimalisasi Game Learning Kahoot dalam Evaluasi Pembelajaran Daring Matematika di SMKN 1 Singgahan Tuban
Authors: Hidayat Rahman
Published: March 2024

Abstract: This descriptive qualitative research offers an evaluation model for Mathematics learning problems that have stagnated due to the rigidity of manual exams and exercises with the Kahoot application. This Kahoot application is equipped with tutorials, pictures, and practical testing tools and their feedback. At least there are some problems in Mathematics learning faced by teachers at SMKN 1 Singgahan Tuban, namely, difficulties in utilizing technological devices, 2) there are limitations in making learning evaluation questions with virtual applications. 3) learning evaluation is still carried out in a monotone. The Kahoot application is an appropriate evaluation model to answer three mathematics learning problems. That is because Kahoot has a small difficulty level, making it easy to practice. Apart from being virtual based and having direct feedback, the Kahoot evaluation model can save all test results into Google Drive. Kahoot application, teachers/educators can offer some questions to answer. Students are more interactive and happy. Moreover, this application is equipped with a rating system as feedback.

Abstrak: Penelitian kualitatif deskriptif ini menawarkan model evaluasi atas problem pembelajaran Matematika yang mengalami stagnasi akibat kekakuan dari ujian dan latihan yang bersifat manual dengan aplikasi Kahoot. Aplikasi Kahoot ini dilengkapi dengan tutorial, gambar dan perangkat alat uji praksis beserta umpan baliknya. Setidaknya ada beberapa problematika pembelajaran Matematika yang dihadapi guru terjadi di SMKN 1 Singgahan Tuban yakni, kesulitan dalam memanfaatkan perangkat teknologi, 2) adanya keterbatasan dalam membuat soal evaluasi pembelajaran dengan aplikasi virtual. 3) evaluasi pembelajaran masih dilakukan dengan monoton. Aplikasi Kahoot adalah model evaluasi tepat untuk menjawab tiga problem pembelajaran Matematika. Hal ini karena Kahoot memiliki tingkat kesulitan yang kecil, sehingga mudah untuk dipraktikan. Selain juga berbasis virtual dan terdapat umpan balik (feedback) langsung, model evaluasi Kahoot dapat menyimpan segala hasil tes ke dalam Google Drive. Aplikasi Kahoot, guru/pendidik dapat menyodorkan beberapa soal untuk dijawab. Peserta didik lebih interaktif dan senang, apalagi aplikasi ini dilengkapi dengan sistem peringkat sebagai umpan balik.

 

DOI: https://doi.org/10.33399/edukasia.v2i1.39