bluuebunny/crossref_metadata_2025 huggingface dataset:
Medición del patrimonio desde dos paradigmas: contabilidad de la riqueza y pensamiento ambiental latinoamericano/sur (complejidad). Caso Plaza de Mercado Leopoldo Rother (Girardot)
Authors: Burbano Pedraza María del Cielo , Niño Bernal Saudy Giovanna , Granados Perdomo Efraín , Romero Buitrago Alexander
Published: February 2025

El objetivo de este artículo es proponer una lectura de la riqueza del patrimonio, a partir del caso de la Plaza de Mercado Leopoldo Rother, como ecosistema sociocultural del municipio de Girardot, como elemento identitario de la cuenca hidrográfica alta del Río Grande de la Magdalena. El marco principal es la declaración de esta plaza como bien de interés cultural (BIC) y su consiguiente amparo y garantía de preservación a través del plan especial de manejo y protección (PEMP), dado según la Resolución 1743 de 2020 del Ministerio de Cultura. Dicha lectura se postula como “medición”, disputando semánticamente este concepto desde dos paradigmas que se presentan con amplitud: la contabilidad de la riqueza (apoyada en la biocontabilidad, la sociocontabilidad y la contametría) y el enfoque de la complejidad, conocido como pensamiento ambiental latinoamericano/sur o movimiento ambientalista colombiano, documentado por pensadores como Julio Carrizosa Umaña, Enrique Leff y Ángel Amaya, entre otros. El documento sustenta por qué hacer medición y valoración desde estos paradigmas y no desde el enfoque económico-financiero tradicional. Ofrece, al tiempo, toda una propuesta propia a partir de los cuestionamientos efectuados y de los hallazgos del proceso mismo de investigación. Esta medición busca ser ilustrativa y operar concienciación sobre cuatro grupos sociales: i) los entes territoriales y gubernamentales que pueden realizar reconocimientos sobre la amplia riqueza de este contexto y de allí tomar decisiones y efectuar gestiones en coherencia con el PEMP; ii) los grupos sociales que hacen parte de este contexto y usan, reconocen o desconocen esta riqueza; iii) los organismos que registran y regulan la contabilidad nacional de la riqueza y; iv) la academia, directivos, docentes y estudiantes, que desde su campo de poder tienen la necesidad de romper paradigmas sobre los alcances y libertad de la contabilidad y de las ciencias ambientales en relaciones transdisciplinares con otros saberes para proteger la riqueza y el patrimonio del país.
Real-word study of racial/ethnic disparities and socioeconomic determinants of overall survival in male breast cancer
Authors: Freeman Jincong Q. , Schechter Kent , Nguyen Long C. , Omoleye Olasubomi J. , Hara Jared H.
Published: February 2025

This study assessed racial/ethnic disparities and socioeconomic determinants of overall survival in male breast cancer. Using the 2010–2021 US National Cancer Database, we identified 20,470 patients: 78.2% White, 13.8% Black, 4.0% Hispanic, and 2.5% Asian or Pacific Islander. After adjusting for clinicopathologic characteristics, Black patients had higher mortality than White patients (adjusted hazard ratio [AHR] 1.22, 95% CI: 1.12–1.32); however, when further adjusting for socioeconomic factors, this difference was no longer significant (AHR 1.09, 95% CI: 0.99–1.21). Hispanic patients had better survival. In the TNBC cohort, Asian or Pacific Islander patients had higher mortality than White patients (AHR 2.35, 95% CI: 1.21–4.55), warranting further investigation. In this US male breast cancer cohort, Black patients and White patients had similar mortality risk after further adjusting for socioeconomic indicators. Higher median household income and private insurance were linked to better survival. Strategies addressing socioeconomic inequities may help improve male breast cancer outcomes.
Host serum amyloid A1 facilitates Streptococcus pneumoniae adaptation to acidic stress induced by pneumococcal anaerobic metabolism
Authors: Gong Weichen , Ono Masayuki , Sumitomo Tomoko , Kobayashi Momoko , Hirose Yujiro , Kawabata Shigetada
Published: February 2025

Serum amyloid A1 (SAA1), an acute-phase protein, exhibits a decreased level in bronchoalveolar lavage fluid (BALF) following nasal Streptococcus pneumoniae infections. However, the function of SAA1 in relation to S. pneumoniae remains to be unclear. In this study, we investigate whether S. pneumoniae utilized SAA1 for its survival in host or not. We explored the function of SAA1 in relation to S. pneumoniae by initially comparing serum with high SAA1 levels to serum with low SAA1 levels. We then validated our findings using recombinant SAA1. In this research, we developed an original PBS-based intranasal administration method to induce SAA1 increases in serum. This innovative approach provides a convenient platform for studying the role of SAA1 in various bacterial species. In vitro experiments showed that when serum-THY broth was incubated with S. pneumoniae, a similar reduction in SAA1 was observed, which was proved to be independent of protease activity. Intake of AF488 (green-fluorescent probe)-conjugated recombinant SAA1 by S. pneumoniae was observed using fluoresence microscope. Then, we proved that intake of SAA1 enhanced S. pneumoniae resistance against formate, a key metabolite of its anaerobic metabolism. This study is the first to reveal the relationship between SAA1 and a Gram-positive bacterium. We demonstrate that S. pneumoniae exploits host acute-phase proteins to enhance its survival in formic acidic environments. These findings expand our understanding of bacterial survival strategies, highlighting how pathogens utilize host-derived components to adapt to hostile conditions.
Exploring the Immediate Effects of an Online Self-Regulation Intervention on Pain, Affect, and Arousal in Women with Endometriosis: An Observational Study Protocol
Authors: Moreira Marcelo de França , Oliveira Marco Aurelio Pinho
Published: February 2025

Background
Endometriosis is a chronic condition that affects millions of women worldwide, causing significant pain, emotional distress, and impaired quality of life. Despite advances in biomedical treatments, many patients continue to experience persistent symptoms due to the complex interplay between biopsychosocial factors, shaped by the lived experience of endometriosis and further exacerbated by socioeconomic adversities common in middle- and low-income countries. Self-regulation, the ability to modulate physiological and psychological responses, addresses core mechanisms underlying emotional challenges and pain, potentially benefiting interconnected difficulties. This study aims to evaluate the immediate effects of an online self-regulation intervention that integrates smooth whole-body movements, postural stillness, and deep breathing, explicitly guiding participants to train adaptive psychological attitudes such as present-centered awareness, nonreactivity, and acceptance through body exercises.
Methods
This observational study employs a within-subject, repeated-measures design to assess pre-to-post-session changes in pain intensity, affect, and arousal in women with symptomatic endometriosis. Assessments include self-reported measures of pain, affective states, and psychological attitudes before and after each session. Statistical analyses will use weighted fixed-effects regression models to estimate immediate changes, adjusting for session and clinical predictors. Mixed-effects models will explore individual variability, accounting for repeated measures within participants. Mediation analysis will examine whether nonreactivity and acceptance explain intervention effects on pain and affective outcomes. Additionally, qualitative analysis will be conducted using thematic content analysis of self-reflexive reports to capture participants' spontaneous narratives regarding their engagement with the intervention and its perceived impact beyond predefined quantitative outcomes. Data collection began in August 2024 at the Endometriosis Outpatient Clinic of Pedro Ernesto University Hospital.
Discussion
By investigating the acute effects of a structured online self-regulation intervention, this study aims to provide insights into non-pharmacological strategies for managing endometriosis-related pain and emotional distress. Understanding the short-term impact of the intervention will help refine its delivery and inform future research on long-term effects. Given the limited accessibility of specialized pain management resources, particularly in low- and middle-income settings, this study may contribute to the development of scalable, low-cost therapeutic approaches.
Identification of a broad-spectrum flavivirus inhibitor targeting NS2A, a previously unidentified target
Authors: Goethals Olivia , Borrenberghs Doortje , Chan Kitti Wing Ki , Brandt Sven Van , Jaensch Steffen , Choy Milly , Geluykens Peggy , Bouayadi Asmae El , Lauwers Dax , Bist Pradeep , Stoops Bart , de Ven Jeroen Van , Vermeulen Peter , Megens Sarah , Peeters Danielle , Kaptein Suzanne , Neyts Johan , Vasudevan Subhash , Koul Anil
Published: February 2025

Flaviviruses, such as dengue virus (DENV), Zika virus (ZIKV), West Nile virus (WNV), Japanese encephalitis virus (JEV), and yellow fever virus (YFV), constitute a significant public health concern with billions of people at risk of infection. Climate change and the expanding geographical distribution of mosquito vectors transmitting flaviviruses have increased their potential to cause large-scale disease outbreaks. The frequency and severity of disease outbreaks highlights the urgent need for a broad-spectrum antiviral agent targeting flaviviruses. In this work, we conducted a comprehensive morphological profiling of approximately 200,000 small molecules through a fluorescence-based high-content imaging platform, which led to the identification of a singular small molecule exhibiting broad-spectrum activity against flaviviruses. Subsequent hit deconvolution against DENV serotype 2 (DENV-2) revealed NS2A as a novel therapeutic target and suggested a mechanism whereby the identified small molecule inhibits the interaction between NS2A and the prM protein, revealing a previously uncharacterized antiviral mechanism of action.
The Effect of Roux-en-Y gastric bypass and sleeve gastrectomy on adults with obesity and its Impact on Their Cardiovascular Risk Assessment Score in Abu Dhabi, United Arab Emirates
Authors: Mazrouei Fatima Mohamed Al , Mohamed Alyaa Ali Aal , Nuaimi Aysha Saeed Al , Mazrouei Ruwayya Zayed Al , Marzooqi Dana Mohamed Al , ALZAROONI Amal Abdul Rahim , Maskari Fatima Al , Torab Fawaz , Nimeri Abdelrahman
Published: February 2025

BACKGROUND Obesity is a global health issue with significant public health implications. In addition, obesity plays a role in the development of obesity-related chronic illnesses like type 2 diabetes [T2DM], dyslipidemia, hypertension [HTN], and major adverse cardiovascular events [MACE]. Metabolic and bariatric surgery leads to significant and sustained weight loss and improves T2DM, HTN, dyslipidemia, and a lower rate of MACEs.OBJECTIVE To assess the impact of Roux-en-Y gastric bypass [RYGB] and sleeve gastrectomy [SG] on Framingham risk score and the major modifiable cardiovascular risk factors including Type 2 Diabetes, dyslipidemia, and hypertension.MATERIALS AND METHODS A single-center retrospective cohort study, for all adult patients with obesity who underwent RYGB or SG at the Bariatric & Metabolic Institute (BMI Abu Dhabi) at Sheikh Khalifa Medical City (SKMC), United Arab Emirates (UAE) from January 2010 to December 2013. The cardiovascular risk score was calculated for 2 years before and 2 years after undergoing RYGB or SG for each patient. Electronic medical records were reviewed. All statistical analysis and data analysis were carried out using the R software, version 3.0.3RESULTS During the study period, 363 adults with obesity underwent bariatric surgery at BMI Abu Dhabi (220 patients had Laparoscopic Roux-en Y gastric bypass (RYGB), 102 patients had Laparoscopic sleeve gastrectomy (SG), and 41 patients had other type of bariatric procedures). The overall risk reduction in cardiovascular risk score was 34.02% over 2 years from baseline. There was a significant reduction in the cardiovascular risk score in the first year after RYGB and SG followed by a plateau for the second year. Additionally, systolic blood pressure (SBP) improved by 9.02%, diastolic blood pressure (DBP) improved by 7.52%, and body mass index (BMI) improved by 39.93%. In addition, the total cholesterol, triglycerides, and low-density lipoprotein (LDL) levels declined by 9.07%, 29.98%, and 21.93% respectively. Furthermore, there was a considerable increase in high-density lipoprotein (HDL) levels of 35.65% over the same time, drop in glycated Hemoglobin (HbA1c) by 10.79%, drop in fasting blood glucose (FBS) by 10.30%, and drop in random blood glucose (RBG) by 15.55%.CONCLUSION A significant reduction in cardiovascular risk score after RYGB and SG was observed. In addition, RYGB and SG led to significant weight loss and improvement in other obesity-related medical conditions.
Mapping the evolution of priorities for health systems evidence synthesis in a low-income country: A case study of Uganda from 2013 to 2023
Authors: OBUKU Ekwaro A. , APUNYO Robert , NABUDEERE Harriet , SEWANKAMBO Nelson K.
Published: February 2025

RATIONALE Resources for conducting health systems research are often limited and yet millions of research articles, systematic reviews, technical reports, and policy briefs are published annually with a significant proportion hardly read, let alone used for decision making. We aimed to identify health systems research priorities for evidence synthesis; assess the availability, evolution and alignment of this evidence with dynamic priorities; and contextualized our findings in Uganda’s health policies and systems. APPROACH This was a multiple methods study between 2013 and 2023, consisting of a mini–Delphi technique to identify health systems research priorities, an uncontrolled before–and–after assessment of availability of research evidence to support the identified priorities, and a qualitative documentary analysis of evolving health policies and systems in Uganda. MAIN FINDINGS Our findings highlighted financial arrangements as a resilient priority area for health system evidence synthesis in Uganda. Secondly, we found an abundance of existing evidence syntheses from the PDQ-Evidence database, in all the areas including health systems governance and human capital development. Third, we mapped the evolution of health systems priorities in Uganda together with the evidence in PDQ-Evidence over the past decade with the emergence of human capital development as a priority policy concern that received massive investment by the Ministry of Health, and indeed highest increase in researched evidence. The organizational realignment of Uganda’s Ministry of Health responded to the evolving health systems priorities in line with agenda 2030 of the sustainable development goals (SDG). CONCLUSIONS Our study findings suggest that access to evidence by decision makers remains an important challenge in bridging the “know–do–gap”. This calls for health systems researchers in Uganda to constantly engage decision makers about where and how to find relevant research evidence, and further refine their information needs. A key starting point is empowering the Uganda National Health Research Organization to provide an integrated knowledge translation platform for the health sector.
Cortical Spectral Dynamics of Vibrotactile Frequency Processing
Authors: Rustamov Nabi , Demarest Phillip , Han Zhuangyu , Mohamud Safia , Haroutounian Simon , Leuthardt Eric C.
Published: February 2025

While scientific research has extensively explored how the brain integrates touch and pain signals, the cerebral processing of specific vibrotactile frequencies remains poorly understood. This gap is particularly significant given clinical evidence that vibrotactile stimulation can reduce pain in both chronic pain patients and experimental settings. Our study investigated the cortical electrophysiological correlates of peripheral vibrotactile stimulation across different frequencies in healthy volunteers, with a focus on frequency-dependent patterns of neuronal activation. While electroencephalogram (EEG) was recorded, healthy participants received vibrotactile stimulation to the left index fingertip at frequencies corresponding to established neural rhythms: delta (2 Hz), theta (6 Hz), alpha (12 Hz), beta (20 Hz), and gamma (40 Hz). We compared the EEG bandwidth activity between vibrotactile stimulation conditions relative to resting baseline. Our findings demonstrated that vibrotactile stimulation produces distinct frequency-dependent patterns of cortical activation. A key finding was that 6 Hz stimulation selectively enhanced theta power in the left prefrontal cortex - an electrophysiological signature previously linked to successful pain relief. These findings advance the understanding of the "spectrotopic" nature of vibrotactile frequency processing in the cortex and provide a mechanistic foundation for developing novel vibration-based therapies in the future.
Study on growth law of austenite grain of by cellular automaton and real-time observation in a high-strength weathering steel
Authors: Cheng Jian , Li Juan
Published: February 2025

This research investigates the development law of austenite grains in a novel V-N microalloyed high-strength weathering steel by cellular automaton and experimental methods. The cellular automaton was employed to mimic the grain transformation of three types of single and smaller grains during austenite grain development.The austenite grains are quadrilateral, hexagonal, or octagonal, each surrounded by a limited number of adjacent grains. The results indicate that during austenite grain development, grains with a boundary number exceeding six continue to expand, approaching a boundary number of six, whereas grains with a boundary number below six progressively decline until they vanish. The austenite grain development process in weathering steel was seen in situ using confocal laser scanning microscopy (CLSM).The CLSM results confirmed the development law of austenite grain as simulated by cellular automata. The used model possesses a superior physical foundation for modeling the advancement of austenite grain development.
Laccase-encapsulated metal-organic frameworks (Lac@MOF): Removal of BPA, a major endocrine disruptor, from the aquatic environment
Authors: ARABACI Gökmen , ÇAĞAN Aleyna , DOĞAÇ Yasemin İSPİRLİ
Published: February 2025

Bisphenol A (BPA) is an endocrine disruptor. The utilization of enzymes in the bioremediation of these compounds offers advantages such as high catalytic efficiency, non-toxicity, high substrate specificity, and short reaction times. However, the use of enzymes in their soluble forms limits their practical applications and presents certain disadvantages, including sensitivity to denaturing agents, non-reusability, and low stability. To address these limitations, enzyme immobilization is a significant method. Recently, porous and large-surface-area metal-organic frameworks (MOFs) have been considered potential candidates for enzyme immobilization. In this study, BPA removal was achieved using an enzymatic process. Encapsulation of laccase was accomplished for the first time during the synthesis of Co2+-and malonic acid-based MOF structures. Optimization and structural characterization (SEM and TGA) of laccase-encapsulated MOF structures (Lac@MOF) were conducted. The enzymatic properties, including temperature, pH, reusability, and kinetic properties of Lac@MOF structures synthesized under optimal conditions, were investigated. The catalytic performance of the laccases increased subsequent to immobilization. The temperature profile at which it exhibited activity broadened and demonstrated enhanced activity in the alkaline range. Notably, the thermal stability results indicated that the activity of the Lac@MOF structures increased by 147% at 60°C, 157% at 70°C, and 134% at 80°C compared to the free enzyme. After the 7th use, 60% of immobilized laccase activity was retained. For BPA, 66% removal was achieved after 230 min.
Enhanced Vehicle Detection in SAR Images via Global and Dual Attention Mechanisms
Authors: LEI Shengjie , WEI Zhiyong , ZHANG Yulian , FANG Meihua , WU Baowen
Published: February 2025

Target detection in Synthetic Aperture Radar (SAR) images is widely applied in various fields, such as geographic information systems, environmental monitoring, disaster warning, urban planning, and military surveillance. Despite the advances in mainstream detection methods, challenges persist in handling complex backgrounds, small targets, and targets with arbitrary orientations. To address these issues, we propose the Global and Dual Attention Network (GDAN), which builds upon the YOLOv5 framework. GDAN incorporates the Spatial Pyramid Pooling Feature Concatenation and Spatial Pyramid Convolution (SPPFCSPC) module to process input images of various sizes and extract multi-level features. The Global Attention Mechanism (GAM) is designed to handle feature interactions in three dimensions simultaneously, enabling adaptive feature aggregation and improving the model's robustness. Furthermore, the Dual Attention (DA) module enables the model to receive multiple feature information from different spatial locations and adaptively acquire global image features. Experimental results demonstrate that GDAN achieves state-of-the-art performance with a mean Average Precision (mAP) of 82.63% on the HighSAR dataset and 91.5% on the VOC dataset, significantly outperforming existing methods. The links to the code https://github.com/ynlsj/Global-and-Dual-Attention-Mechanisms/, dataset(https://github.com/whu-csl/SAR_vehicle_detection_dataset and http://host.robots.ox.ac.uk/pascal/VOC/voc2012/ )
Challenging Pro-Growth Dynamics by Developing Planning Knowledges for Diverse Economies
Authors: Rydin Yvonne
Published: February 2025

The paper examines the knowledges that post-growth planning will require and in which planners should be centrally involved in generating and fostering. It argues that developing such knowledges could help re-align planning agendas away from growth-dependence. It uses Gibson-Graham’s
diverse economies approach to build a framework for researching aspects of diverse economies that could pre-figure a postgrowth future. The proposition is that examples of alternatives are already present within diverse economies and, if supported, could present a significant challenge to
the pro-growth hegemony. The paper draws on an extensive review of the research literature alongside European case studies of neo-endogenous development, cooperatives, community land trusts, social enterprises managing community assets, community-owned infrastructure, and urban commoning.
Lessons are drawn for the kinds of knowledges needed to enable the shift to more diverse economies, looking across new ways of understanding the locality and the importance of networks in circulating and adapting knowledge. The paper ends with a consideration of how this would change the nature
of local planning.
Unveiling the Therapeutic Promise of Indole and Thiazole Derivatives in Treating Lung Diseases
Authors: Raj Smriti , Patle Deepshikha , Kumar Banoth Karan
Published: February 2025

Heterocyclic scaffolds, particularly indole and thiazole compounds, are revolutionizing the treatment
of lung diseases due to their structural diversity and broad therapeutic potential. Their ability to target multiple
biological pathways positions them as powerful tools for developing innovative treatments for lung disorders,
particularly lung cancer. This review systematically explores recent advances in the synthesis and biological
evaluation of indole and thiazole derivatives, emphasizing detailed synthetic strategies and the identification of
the most potent molecules reported in the studies referenced within this manuscript for their relevance to lung
diseases, particularly lung cancer. The SAR studies elucidate the role of molecular features and key functional
groups in enhancing the potency, selectivity, and therapeutic efficacy of synthetic indole and thiazole derivatives.
Given that lung cancer remains the leading cause of cancer-related deaths worldwide, the findings highlight
the urgent need for developing innovative and effective anti-lung cancer agents, with indole and thiazole
scaffolds serving as promising therapeutic frameworks.
Recent Accomplishments in Exhaled Breath Condensate Analysis - Molecular Aspects
Authors: Silkin Sergey V. , Pekov Stanislav I. , Bocharov Konstantin V. , Popov Igor A.
Published: February 2025

Nowadays, the research of exhaled breath condensate (EBC) analysis is
widely discussed in the scientific community. The growing interest in EBC analysis
results is related to the ample advantages of non-invasive techniques in healthcare
and related fields. In particular, EBC analysis can be used to diagnose respiratory
diseases, monitor the disease’s course during therapy, and monitor drug intake and
metabolism. This review aims to systematize the accumulated knowledge on EBC
collection, concentration, storage, and analysis methods and compare them with
similar procedures for exhaled breath (EB). We proposed a generalized chemical
classification of EBC compounds that are biomarkers for various diseases. The
potential transformation of substances during EB condensation was considered, and
EBC analysis methods were systematically categorized based on this classification.
Methods for EBC analysis using chromatographic separation with mass spectrometric
detection (hyphenated methods) were separately discussed as the most promising
methods for future research applications.
Enhanced Electrochemical Performance Using Polyaniline/BiPr Composite Nanosheet-modified Glassy Carbon Electrode
Authors: Cai Zhengyu , Chang Yuetong , Pei Mengyan , Huang Jianfeng , Pei Lizhai
Published: February 2025

Background:

L-cysteine (L-CySH) plays a crucial physiological role in the life-support
system, which has been widely applied in the food and medicine industries. Abnormal content of LCySH
in the human body can lead to liver damage, Alzheimer's disease, and even cancer. Therefore,
it is of great practical importance to investigate highly sensitive and selective methods for the determination
of L-CySH.

Methods:

L-CySH electrochemical detection by cyclic voltammetry (CV) technique was reported
using the polyaniline/BiPr composite nanosheet-modified glassy carbon electrode (GCE).

objective:

Polyaniline/BiPr composite nanosheets modified glassy carbon electrode (GCE) was used for L-cysteine (L-CySH) electrochemical detection by cyclic voltammetry (CV) technique.

Results:

The obtained nanosheets with a size of less than 500 nm were composed of rhombohedral
Bi1.35Pr0.65O3, tetragonal Bi2O3, and hexagonal Pr2O3. Irregular polyaniline nanoparticles were covered
on BiPr nanosheets. Polyaniline/BiPr composite nanosheet-modified GCE had good electrocatalytic
performance for L-CySH detection. A pair of CV peaks was observed on the BiPr composite
nanosheet-modified GCE with the potentials at +0.06 V and –0.75 V. Peak potentials at the polyaniline/
BiPr composite nanosheet-modified GCE were shifted to –0.09 V and –0.72 V. The linear
range detection limit indicated 0.0005–2 mM and 0.086 μM for the polyaniline/BiPr composite
nanosheet-modified GCE.

Conclusion:

Polyaniline/BiPr composite nanosheets provide a kind of new electrode material for
improving the electrochemical performance towards L-CySH determination.
Optimizing Gold Nanoparticle Size and Aggregation Strategies for Enhanced Sers: A Comprehensive Review
Authors: Zulhanip Aida Zulia , Mohamad Hadis Nor Shahanim , Mohd Radzol Afaf Rozan , Rosli Anis Diyana
Published: February 2025

Surface-enhanced Raman scattering (SERS) is an ultrasensitive spectroscopy technique
that leverages localized surface plasmon resonance (LSPR) in nanostructured metallic substrates.
Its ability to detect and analyze molecules at very low concentrations is certain; however, the effectiveness
is highly dependent on the size and aggregation state of the nanoparticles used as a substrate.
This study analyzes the correlation between key sensitivity parameters consisting of enhancement
factor (EF) and limit of detection (LOD) in relation to the enhanced SERS. The effects of
sensitivity associated with suitably sized nanoparticles focusing on gold nanoparticles (AuNPs)
and their implementation of SERS are comprehensively analyzed. The method for controlling
nanoparticle aggregation is also reviewed as a complementary strategy to enhance SERS performance
alongside the optimal size. The findings indicate that the AuNPs with sizes below 55 nm
provide higher EF and lower LOD due to the increased strength of the electromagnetic field, although
they may suffer from aggregation instability compared to the larger nanoparticles. To manage
this concern, the integrated strategies involving chemical, physical, and self-assembly techniques
of controlled aggregation of AuNPs have a significant impact on forming SERS hot spots
and amplifying signals. Therefore, an adaptation of the approaches to obtain the optimal size and
well-distributed aggregation of AuNPs to achieve a reliable SERS substrate in various applications
serves as a decisive factor. This study identifies the current gaps to address the diversity of
accessible sizes of AuNPs, aggregation control, and challenges in evaluating AuNPs and introduces
a future path for achieving a reliable SERS substrate in diverse applications.
Relationship Between Depressive Symptoms and Hearing Impairment in the Elderly
Authors: Kösemihal Ebru , Cesur Sıdıka
Published: February 2025

Objective: This study aims to examine the relationship between the severity of hearing impairment and psychological symptoms in the elderly.
Methods: A cross-sectional survey was conducted using Google Forms distributed via social media and hearing aid dispensers to participants aged 65 and above in Turkey and Northern Cyprus. The survey included demographic questions, the Hearing Handicap Inventory for the Elderly-Screening version (HHIE-S), and the Beck Depression Inventory (BDI).
Results: The sample comprised 246 participants (102 males, 144 females) with a mean age of 72.58 ± 7.75 years. The median score for the HHIE-S was 22. Of the participants, 6.9% reported no hearing handicap, 50.8% reported moderate, and 42.3% reported severe hearing handicap. Hearing aid users had higher HHIE-S scores. The median BDI score was 29, with 3.3% of participants classified as minimal, 17.5% mild, 39% moderate, and 40.2% severe depression. A statistically significant difference in BDI scores was found among groups based on HHIE-S impairment levels (p=0.000). Gender differences were not significant for HHIE-S (p = 0.167) or BDI (p = 0.072), but marital status, education, and income level showed significant differences across groups.
Conclusion: This study revealed that hearing handicaps and symptoms of depression are prevalent among individuals over the age of 65. Those reporting hearing handicaps have a higher rate of depression. Age, marital status, education, and income level effects hearing handicap and depression levels. No effect of gender on hearing handicaps or depression was observed. The use of hearing aids may contribute to a reduction in depression scores among individuals reporting hearing impairment.
Exploring the Relationship Between Parental Trauma, Parenting Style, and Children’s Medical Treatment Adherence (Preprint)
Authors: Stull Margaret , Vsevolozhskaya Olga , Collman Kristopher , Steinken Rachel , Rios Christina , Meadows Amy
Published: February 2025

BACKGROUND

Different factors, such as parental trauma or parenting style, may influence their child(ren)’s medical treatment adherence. Authoritative, or “flexible” parenting is known to develop the most nurturing relationship between parent and child(ren).

OBJECTIVE

This study examines the relationship between parental trauma, parenting style, and their child(ren)’s adherence to medical recommendations.

METHODS

Participants were recruited through Amazon.com’s Mechanical Turk (mTurk), an online crowdsourcing platform. Participants were 18 years or older, a caregiver for at least one child under the age of 18, and had at least one child who was prescribed medication within the past three months. Parental trauma level was measured via the Adverse Childhood Experiences (ACE’s) questionnaire and parenting style was measured via the Parental Authority Questionnaire-Revised (PAQ-R). Descriptive statistics, including chi-square tests, t-tests, and adjusted logistic regressions were utilized to determine the association between parental trauma, parenting style, and their child(ren)’s medical adherence.

RESULTS

A total of 723 participant responses were analyzed. Children who were medically adherent were younger (p=0.016) and of Caucasian ethnicity. Caregiver's mean age was 36.8 years old and 35.4% identified as male. An increase in caregiver’s ACE score was marginally associated with an increased risk of medication non-adherence among their children (adjusted odds ratio (OR) 0.94, P = 0.066).

CONCLUSIONS

Similar to other studies, this study showed that parents of children who adhere to medical treatment practice an authoritative parenting style. Uniquely, it also showed that an increased ACE score was only marginally associated with an increased risk of medical non-adherence.
Major element analysis in sedimentary rocks from the Middle Mississippian–Middle Pennsylvanian La Joya section in Sierra Agua Verde, Sonora, Mexico
Authors: Villanueva-Olea Rafael , Sánchez-Beristain Francisco , Palafox-Reyes Juan José , Buitrón-Sánchez Blanca Estela
Published: February 2025

The Sierra Agua Verde is a significant paleontological site in northwestern Mexico. While numerous stratigraphic and paleontological studies have been conducted in this area, a lack of geochemical research has hindered a complete understanding of its paleoenvironmental context. Our study primarily focused on examining the fossiliferous limestone from the Middle Mississippian to Middle Pennsylvanian periods in the region. By utilizing X-ray fluorescence (XRF), we measured major element oxide concentrations in bulk rock limestone samples. This analysis helped us infer the paleoenvironmental conditions through elemental ratios and correlation coefficients. The samples displayed calcium enrichment, with some also exhibiting high magnesium/calcium (Mg/Ca) ratios. The silicon/aluminum (Si/Al) ratio, akin to Si/Ca, was interpreted as indicative of productivity, potentially attributed to the presence of siliceous sponges. Nevertheless, elevated silicon values could also result from continental weathering processes. Peaks in elemental values apart from calcium may indicate episodes of riverine influx onto the carbonate platform where these sediments settled. We related the curve of major elements to previous stable isotope studies to determine if detrital element input aligned with global or regional climate conditions. Our hypotheses were corroborated by statistical analysis, yielding dendrograms that highlighted associations between elements such as Al and K, as well as Fe and Ti (Morisita Index). This could suggest the precipitation of minerals like orthoclase/illite and ilmenite. Moreover, the increasing divergence between Mg and Mn in comparison to the Al-K clade, along with Si, might explain the strong Fe-Ti connection, reflecting the tendency of both Mn and Ti to form oxides. The co-precipitation of Si and P might also be linked to productivity episodes. However, the Si content could indicate either quartz input or biogenic silica contribution.
Herramientas basadas en inteligencia artificial en la publicación científica, ¿herramientas de apoyo o promotoras de malas prácticas?
Authors: Díaz Gloria Mercedes , Escobar Adolfo
Published: February 2025

La inteligencia artificial, esa tecnología que pareciera haber emergido de repente hace apenas unos años, pero que lleva varias décadas de desarrollo, se ha convertido en uno de los temas de mayor interés a nivel mundial. Una consulta en la muy conocida herramienta de Google Trends (https://trends.google.com), nos muestra cómo la búsqueda del concepto alcanzó un máximo en el mes de mayo de 2023, tan sólo un mes después del lanzamiento de GPT-4. Este modelo de inteligencia artificial generativa es capaz de simular conversaciones humanas, en respuesta a preguntas específicas, y permite incluso crear documentos completos con una legibilidad similar a la de los textos creados por humanos. Ese mismo mes, también fue el lanzamiento de la actualización conocida como GPT-4o, la cual mostró al mundo la capacidad para la interpretación y generación realista de texto, imágenes, vídeos y voz, en más de 50 idiomas.
Использование электронных образовательных ресурсов в информационной образовательной среде
Authors: Ничагина А.В.
Published: February 2025

Автор рассматривает основные подходы использования электронных образовательных ресурсов педагогами и студентами в информационной образовательной среде с учетом современных требований, предъявляемых к высшим учебным заведениям в Российской Федерации. Содержание данной статьи является особенно актуальным в связи с возросшей необходимостью обеспечения образовательных программ возможностями дистанционного или смешанного обучения. Автором проведен глубокий анализ терминологического аппарата в рамках заявленной проблематики, а также выделены ключевые аспекты и проблемы, связанные с функционированием систем дистанционного обучения, с предложением возможных путей их решения на основе практического опыта. Кроме того, в работе уточняется понятие информационной образовательной среды и приводится классификация различных видов онлайн-обучения, образовательных порталов и ресурсов, применяемых в российских вузах. Особое внимание автор акцентирует на сравнительном анализе наиболее перспективных (с точки зрения ведущих средств массовой информации) образовательных платформ и технологий электронного обучения, раскрывая их сильные и слабые стороны. Также в статье рассматривается жизненный цикл электронного образовательного ресурса (от планирования до использования) на примере ресурса «Производственная практика», который был применен в ходе педагогической (производственной) практики студентов на территории Российской Федерации. Автором выделены наиболее эффективные формы и методы организации работы студентов на каждом из этапов.

The author considers the main approaches to the use of electronic educational resources by teachers and students in the information educational environment, taking into account modern requirements for higher education institutions in the Russian Federation. The content of this article is especially relevant due to the increased need to provide educational programs with distance or blended learning opportunities. The author has conducted an in-depth analysis of the terminological apparatus of the stated problems, highlighted the key aspects and problems of the functioning of distance learning systems and proposed possible ways to solve them based on practical experience. In addition, the paper clarifies the concept of an information educational environment and provides a classification of various types of online learning, educational portals and resources used in Russian universities. The author focuses special attention on the comparative analysis of the most promising from the point of view of the leading mass media, educational platforms and e-learning technologies, revealing their strengths and weaknesses. The article also examines the life cycle of an electronic educational resource (from planning to use) using the example of the resource «Industrial Practice», which was applied during the pedagogical (industrial) practice of students in the Russian Federation. The author identifies the most effective forms and methods of organizing students' work at each stage.
Det handler om krigen: Norske meninger om Nato og EU før og etter Russlands fullskala invasjon av Ukraina
Authors: Tvinnereim Endre
Published: February 2025

Russlands fullskala invasjon av Ukraina i februar 2022 var et sjokk som forandret den norske opinionen i utenrikspolitiske spørsmål. Data fra Norsk medborgerpanel viser at støtten til Natos styrkeoppbygging i Øst-Europa økte betydelig mellom 2016 og 2022–24. Det er også signifikant flere som er positive til norsk EU-medlemskap etter februar 2022, men disse utgjør fremdeles et mindretall. Data samlet inn fra de samme individene før og etter invasjonen viser at forandringen i holdninger til EU-medlemskap er særlig stor blant de eldre og høyt utdannede. Dette var også gruppene som i utgangspunktet var mest positive til EU, noe som tyder på en klarere segmentering av opinionen i EU-spørsmålet.
Abstract in English:It’s About the War: Norwegian Public Opinion About NATO and the EU Before and After Russia’s Full-scale Invasion of UkraineRussia’s full-scale invasion of Ukraine in February, 2022, constituted a shock that transformed Norwegian public opinion about foreign policy. Data from the Norwegian Citizen Panel show that support for strengthening of Nato’s military forces in Eastern Europe increased markedly from 2016 to 2022–24. Support for Norwegian membership in the European Union has also increased significantly in the wake of February, 2022, but supporters remain a minority. Data collected from the same individuals before and after the invasion show that the change in opinion toward EU membership is particularly large among older respondents and those with higher education. Since these groups were already more in favour of EU membership, the data indicate a clearer segmentation of public opinion on this question.
Post-Truth Reality: Worldwide Infodemia and Mental Health Concerns during and Post COVID-19 Pandemic Scenarios
Authors: SM Chavez-Valdez
Published: February 2025

Introduction: The health emergency due to COVID-19 added to the pre-existing mental health panorama, especially with respect to perceived stress, anxiety and depression, to the risk cognition that the infodemia entails, together with the economic
and psychosocial ones, triggered a mental health pandemic in the medium and long term. mental health.
Aim: Describe associations between infodemia, mental and psychosocial health as well as associated conditions in the population during the contingency due to the SARS-CoV2 pandemic.
Methods: A cross-sectional, empirical, descriptive study was carried out through a documentary review.
Results: Massive information promotes beliefs, values and ideals endorsed as real that misinform, generating chaos in virtual
communities disregarding scientific evidence, consequently, detonating greater physical and mental vulnerability that reinforced a pandemic mental health crisis due to SARS-COV2.
TRANSFORMING PRODUCT INNOVATION TO MEET CUSTOMER NEEDS THROUGH AI MARKETING, A CUSTOMER FEEDBACK ANALYSIS WITH GPT-4O MINI
Authors: Sudirman Ivan , Sudirman Iman , Setiawan Margareth , Rahmatillah Intan
Published: February 2025

This research uses GPT to conduct sentiment analysis on customer reviews for biodegradable products. Sentiment analysis uses 4 categories, namely positive, negative, neutral and mixed, then for product improvement this study focuses on negative sentiment by adding negative sentiments from the mixed sentiments. Data collected from Amazon reviews regarding one brand of biodegradable trash bag in several stores. The GPT-4o Mini model was then used to categorize sentiment.The results of sentiment analysis show that most reviews are positive, but there are also many negative sentiments regarding product durability, leakage and price. The model used is able to accurately identify and extract negative sentiment even from a mixed sentiment, thereby providing a more complete understanding of customer dissatisfaction. This research emphasizes the importance of integrating AI-driver sentiment analysis into the marketing process.
IMPACT OF 5S ON BUSINESS PERFORMANCE THROUGH LEAN MANAGEMENT AND BLUE OCEAN LADERSHIP IN THE INDONESIAN MANUFACTURING INDUSTRY
Authors: Maemunah Siti , Rayyan Rayyan
Published: February 2025

Business competition in the manufacturing sector is increasingly high and unpredictable. Tight investment in capital and human resources requires companies to ensure 5S practices, the basic concepts of Japanese culture and lean management need to be applied to improve business performance in Indonesia, especially at PT. Manufacturing. This research uses a PLS-SEM approach. A total of 85 respondents were in division head positions. The research results show that 5S has no direct or indirect influence on business performance. The results show that lean management and blue ocean leadership do not have a mediating effect between 5S and business performance. Blue ocean leadership has not been implemented optimally by the leadership, so performance has not met expectations. Contribution of researchers to PT. Manufacturing helps top management in companies implement and execute 5S well in the company. The second contribution concerns the need to improve lean management in the pull system.
Efecto del tratamiento con ácido fólico y carboplatino sobre la viabilidad de células no tumorales
Authors: Manso González Sasha T. , Gambaro Rocío C. , Seoane Analía I. , Padula Gisel
Published: February 2025

Las células cancerígenas están muy adaptadas y suelen ser resistentes a los agentes antitumorales, lo cual impedimenta una terapia efectiva contra el cáncer. Sin embargo, en estas células se encuentran factores que pueden modificar la respuesta al tratamiento quimioterapéutico. Resultados previos, obtenidos en células tumorales HeLa, demostraron que el ácido fólico (AF) combinado con el carboplatino (CBP) permitía bajar la dosis de CBP utilizada y aumentar la actividad del compuesto platinado. En este sentido, es imprescindible evaluar los efectos de dicho tratamiento en las células sanas. Por este motivo, se analizó el efecto del tratamiento combinado de AF y CBP in vitro sobre la viabilidad celular (ensayo MTT) utilizando sangre periférica de mujeres sanas. Los cultivos se realizaron por 48 horas a 37°C, durante las últimas 24 horas se efectuaron los tratamientos: 1. control negativo (CN); 2. control AF (900 nM); 3. control CBP (40,4 mM); 4. control de manitol (ML 40,4 mM); 5. combinado AF-CBP (900 nM-40,4 mM); 6. combinado AF-ML (900 nM-40,4 mM); 7. control positivo (CP etanol 10%). Los cultivos que recibieron la combinación AF-CBP presentaron una viabilidad similar a la observada para el CN. Por el contrario, en los cultivos que recibieron el tratamiento sólo con CBP la viabilidad disminuyó de manera estadísticamente significativa respecto de dicho control. Estos hallazgos podrían resultar un aporte explorando el uso del AF en protocolos basados en agentes platinados, con el fin de reducir las dosis en el tratamiento de pacientes y la aparición de efectos secundarios.
REALITA BUDAYA PABALIAN DI DESA BUNTU BARANA KECAMATAN CURIO KAB. ENREKANG
Authors: Muhtadiyah Ikrimah Al Muhtadiyah , M. Muzakkir  , Muhammad Yahdi
Published: February 2025

Artikel ini bertujuan untuk mengetahui nagaimana realita  pabalian di desa Buntu Barana kecamatan Curio kabupaten Enrekang. Jenis penelitian ini tergolong kualitatif dengan pendekatan penelitian yang digunakan adalah: fenomenologi, sosiologi dan etnografi. Adapun sumber data dalam penelitian ini yaitu Kepala Desa, Kepala Dusun, tokoh pendidik dan masyarakat di desa Buntu Barana. Selanjutnya metode pengumpulan data yang digunakan adalah observasi, wawancara dan dokumentasi. Lalu Teknik pengolahan dan analisis data dilakukan melalui tiga tahap, yaitu: reduksi data, penyajian data, dan penarikan kesimpulan. Hasil penelitian ini  menunjukkan bahwa realita pabalian di desa Buntu Barana dari keenam bentuk pabalian yang sudah disebutkan sebelumnya ada satu bentu pabalian yang partisipannya sudah berkurang yaitu menanam padi disebabkan oleh beberapa faktor yaitu kemajuan teknologi, kemajuan ilmu pengetahuan, saling mengharapkan dan sudah adanya kebun dan tanaman jangka panjang. Implikasi dari penelitian ini adalah memberikan pesan moral kepada masyarakat di desa Buntu Barana kecamatan Curio kabupaten Enrekang bahwa pentingnya budaya pabalian untuk tetap dipertahankan dan dikembangkan, karena di dalamnya terdapat nilai-nilai Pendidikan Islam dan juga karena tolong menolong sangat dibutuhkan sebagai makhluk sosial.