bluuebunny/crossref_metadata_2025 huggingface dataset:
Structural characterization of a breast cancer-associated mutation in caveolin-1
Authors: Han Bing , Gulsevin Alican , Connolly Sarah , Wang Ting , Porta Jason , Tiwari Ajit , Deng Angie , Chang Louise , Peskova Yelena , Mchaoraub Hassane S. , Karakas Erkan , Ohi Melanie D. , Meiler Jens , Kenworthy Anne K.
Published: May 2022

Caveolin-1 (CAV1) is a membrane sculpting protein that oligomerizes to generate flask-shaped invaginations of the plasma membrane known as caveolae. Mutations in CAV1 have been linked to multiple diseases in humans. Such mutations often interfere with oligomerization and the intracellular trafficking processes required for successful caveolae assembly, but the molecular mechanisms underlying these defects have not been structurally explained. Here, we investigate how a breast cancer-associated mutation in one of the most highly conserved residues in CAV1, P132L, affects CAV1 structure and oligomerization. We show that P132 is positioned at a major site of protomer-protomer interactions within the CAV1 complex, providing a structural explanation for why the mutant protein fails to homo-oligomerize correctly. Using a combination of computational, structural, biochemical, and cell biological approaches, we find that despite its homo-oligomerization defects P132L is capable of forming mixed hetero-oligomeric complexes with wild type CAV1 and that these complexes can be incorporated into caveolae. These findings provide insights into the fundamental mechanisms that control the formation of homo- and hetero-oligomers of caveolins that are essential for caveolae biogenesis, as well as how these processes are disrupted in human disease.
Perceptual decisions exhibit hallmarks of dynamic Bayesian inference
Authors: Charlton Julie A. , Młynarski Wiktor F. , Bai Yoon H. , Hermundstad Ann M. , Goris Robbe L. T.
Published: May 2022

To interpret the sensory environment, the brain combines ambiguous sensory measurements with context-specific prior experience. But environmental contexts can change abruptly and unpredictably, resulting in uncertainty about the current context. Here we address two questions: how should context-specific prior knowledge optimally guide the interpretation of sensory stimuli in changing environments, and do human decision-making strategies resemble this optimum? We probe these questions with a task in which subjects report the orientation of ambiguous visual stimuli that were drawn from three dynamically switching distributions, representing different environmental contexts. We derive predictions for an ideal Bayesian observer that leverages the statistical structure of the task to maximize decision accuracy and show that its decisions are biased by task context. The magnitude of this decision bias is not a fixed property of the sensory measurement but depends on the observer’s belief about the current context. The model therefore predicts that decision bias will grow with the reliability of the context cue, the stability of the environment, and with the number of trials since the last context switch. Analysis of human choice data validates all three predictions, providing evidence that the brain continuously updates probabilistic representations of the environment to best interpret an uncertain, ever-changing world.

SIGNIFICANCE

The brain relies on prior knowledge to make perceptual inferences when sensory information is ambiguous. However, when the environmental context changes, the appropriate prior knowledge often changes with it. Here, we develop a Bayesian observer model to investigate how to make optimal perceptual inferences when sensory information and environmental context are both uncertain. The behavioral signature of this strategy is a context-appropriate decision bias whose strength grows with the reliability of the context cue, the stability of the environment, and with the number of decisions since the most recent change in context. We identified exactly this pattern in the behavior of human subjects performing a dynamic orientation discrimination task. Together, our results suggest that the brain continuously updates probabilistic representations of the environment to make perceptual decisions in the face of uncertainty over both sensory and contextual information.
Multiplexed microfluidic platform for stem-cell derived pancreatic islet β cells
Authors: Goswami Ishan , de Klerk Eleonora , Carnese Phichitpol , Hebrok Matthias , Healy Kevin E.
Published: May 2022

Stem-cell derived β cells offer an alternative to primary islets for biomedical discoveries as well as a potential surrogate for islet transplantation. The expense and challenge of obtaining and maintaining functional stem-cell derived β cells calls for a need to develop better high-content and high-throughput culture systems. Microphysiological systems (MPS) are promising high-content in vitro platforms, but scaling for high-throughput screening and discoveries remain a challenge. Traditionally, simultaneous multiplexing of liquid handling and cell loading poses a challenge in the design of high-throughput MPS. Furthermore, although MPS for islet beta culture/testing have been developed, studies on multi-day culture of stem-cell derived β cells in MPS have been limited. We present a scalable, multiplexed islet beta MPS device that incorporates microfluidic gradient generators to parallelize fluid handling for culture and test conditions. We demonstrated the viability and functionality of the stem-cell derived enriched β clusters (eBCs) for a week, as assessed by the ~2 fold insulin release by the clusters to glucose challenge. To show the scalable multiplexing for drug testing, we demonstrated the exhaustion of eBC insulin reserve after long term exposure to logarithmic concentration range of glybenclamide. The MPS cultured eBCs also revealed a glycolytic bottleneck as inferred by insulin secretion responses to metabolites methyl succinate and glyceric acid. Thus, we present an innovative culture platform for eBCs with a balance of high-content and high-throughput characteristics.
PKN2 deficiency leads both to prenatal ‘congenital’ cardiomyopathy and defective angiotensin II stress responses
Authors: Marshall Jacqueline J T , Cull Joshua J , Alharbi Hajed O , Thin May Zaw , Cooper Susanna TE , Barrington Christopher , Vanyai Hannah , Snoeks Thomas , Siow Bernard , Suáarez-Bonnet Alejandro , Herbert Eleanor , Stuckey Daniel J , Cameron Angus , Prin Fabrice , Cook Andrew C. , Priestnall Simon L , Chotani Sonia , Rackham Owen J L , Meijles Daniel N , Mohun Tim , Clerk Angela , Parker Peter J
Published: May 2022

Background

The protein kinase PKN2 is required for embryonic development, and PKN2 knockout mice die as a result of failure in expansion of mesoderm tissues, cardiac development and neural tube closure. In the adult, cardiomyocyte PKN2 and PKN1 (in combination) are required for cardiac adaptation to pressure-overload. The role of PKN2 in contractile cardiomyocytes during development and its role in the adult heart remain to be fully established.

Methods

We used mice with cardiomyocyte-directed knockout of PKN2 or global PKN2 haploinsufficiency. Cardiac function and dimensions were assessed with high resolution episcopic microscopy, MRI, micro-CT and echocardiography. Biochemical and histological changes were assessed.

Results

Cardiomyocyte-directed PKN2 knockout embryos displayed striking abnormalities in the compact myocardium, with frequent myocardial clefts and diverticula, ventricular septal defects and abnormal heart shape. The sub-Mendelian homozygous knockout survivors developed cardiac failure. RNASeq data showed upregulation of PKN2 in patients with dilated cardiomyopathy, suggesting an involvement in adult heart disease. Given the rarity of homozygous survivors with cardiomyocyte-specific deletion of PKN2, this was explored using mice with constitutive heterozygous PKN2 knockout. Cardiac hypertrophy resulting from hypertension induced by angiotensin II was reduced in haploinsufficient PKN2 mice relative to wild-type littermates, with suppression of cardiomyocyte hypertrophy and cardiac fibrosis.

Conclusions

Cardiomyocyte PKN2 is essential for heart development and formation of compact myocardium, and is also required for cardiac hypertrophy in hypertension. Thus, PKN signalling may offer therapeutic options for managing congenital and adult heart diseases.
Cyclin A and Cks1 promote kinase consensus switching to non-proline directed CDK1 phosphorylation
Authors: al-Rawi Aymen , Korolchuk Svitlana , Endicott Jane , Ly Tony
Published: May 2022

Ordered protein phosphorylation by CDKs is a key mechanism for regulating the cell cycle. How temporal order is enforced in mammalian cells remains unclear. Using a fixed cell kinase assay and phosphoproteomics, we show how CDK1 activity and non-catalytic CDK1 subunits contribute to the choice of substrate and site of phosphorylation. Increases in CDK1 activity alters substrate choice, with intermediate and low sensitivity CDK1 substrates enriched in DNA replication and mitotic functions, respectively. This activity dependence was shared between Cyclin A- and Cyclin B-CDK1. Cks1 has a proteome-wide role as an enhancer of multisite CDK1 phosphorylation. Contrary to the model of CDK1 as an exclusively proline-directed kinase, we show that Cyclin A and Cks1 promote non-proline directed phosphorylation, preferably on sites with a +3 lysine residue. Indeed, 70% of cell cycle regulated phosphorylations, where the kinase carrying out this modification has not been identified, are non-proline directed CDK1 sites.
Phase-separated nuclear bodies of nucleoporin fusions, SET-NUP214 and NUP98-HOXA9, promote condensation of MLL1 and CRM1 to activate target genes
Authors: Oka Masahiro , Otani Mayumi , Miyamoto Yoichi , Adachi Jun , Tomonaga Takeshi , Asally Munehiro , Ohkawa Yasuyuki , Yoneda Yoshihiro
Published: May 2022

Nucleoporins NUP98 and NUP214 form chimeric fusion proteins that assemble into phase-separated nuclear bodies. However, the function and physiological significance of these nuclear bodies remain largely unknown. Previously, we reported that both NUP98-HOXA9 and SET-NUP214 are recruited to HOX cluster regions via chromatin-bound CRM1, a nuclear export receptor (Oka et al., 2019). Here, we show that these nuclear bodies promote the condensation of mixed lineage leukemia 1 (MLL1), a histone methyltransferase which is essential for the maintenance of HOX gene expression. Our analysis revealed that SET-NUP214 and CRM1 robustly associate with MLL1 to form nuclear bodies and are colocalized on chromatin. We also showed that MLL1 and CRM1 are recruited to the nuclear bodies of NUP98-HOXA9 and that the NUP98-HOXA9/CRM1/MLL1 complex accumulates on its target gene loci, including HOX clusters and MEIS1. These phenomena were not observed in phase-separation–deficient mutants or non-DNA-binding mutants of NUP98-HOXA9. Collectively, these results show that both phase separation and proper targeting of nucleoporin fusions to specific sites could enhance the activation of a wide range of target genes by promoting the condensation of MLL1 and CRM1.
The AMPK activator A-769662 inhibits human TASK3 potassium channels in an AMPK-independent manner
Authors: Said Esraa A. , Lewis Ryan W. , Dallas Mark L. , Peers Chris , Ross Fiona A. , Hardie D. Grahame , Evans A. Mark
Published: May 2022

Heteromeric TASK1/3 channels play a fundamental role in oxygen-sensing by carotid body type 1 cells, where hypoxia-induced inhibition of TASK3 and/or TASK1/3 potassium currents leads to depolarisation, voltage-gated calcium entry, exocytotic transmitter release and increases in carotid body afferent input responses that initiate corrective changes in breathing patterns. However, the mechanism by which hypoxia leads to TASK-1/3 channel inhibition is still debated. It had been proposed that the AMP-activated protein kinase (AMPK) might directly phosphorylate and inhibit TASK channels, in particular TASK-3, although subsequent studies on rat type I cells argued against this view. Here we report on the effects of novel, highly selective AMPK activators on recombinant human TASK-3 potassium channels. Sequence alignment identified an AMPK recognition motif in TASK-3, but not TASK-1, with Ser55 representing a potential site for AMPK-dependent phosphorylation in TASK-3. However, neither of the AMPK activators, AICAR or MK-8722, caused a significant reduction of human TASK-3 current amplitude. By contrast, high concentrations of the AMPK activator A-769662 (100-500 µM) inhibited human TASK-3 currents in a concentration-dependent manner. Importantly, A-769662 (300 µM) also inhibited human TASK-3 channels in HEK293 cells that stably over-expressed an AMPK-β1 subunit mutant (S108A) that renders AMPK insensitive to activators binding the Allosteric Drug and Metabolite (ADaM) site, such as A-769662. We therefore identify A-769662 as a novel human TASK-3 channel inhibitor and provide conclusive evidence that AMPK does not regulate TASK-3 channel currents.
Morphological profiling by high-throughput single-cell biophysical fractometry
Authors: Zhang Ziqi , Lee Kelvin C. M. , Siu Dickson M. D. , Lai Queenie T. K. , Lam Edmund Y. , Tsia Kevin K.
Published: May 2022

Complex and irregular cell architecture is known to statistically exhibit fractal geometry, i.e., a pattern resembles a smaller part of itself. Although fractal variations in cells are proven to be closely associated with the disease-related phenotypes that are otherwise obscured in the standard cell-based assays, fractal analysis with single-cell precision remains largely unexplored. To close this gap, here we develop an image-based approach that quantifies a multitude of single-cell biophysical fractal-related properties at subcellular resolution. Taking together with its high-throughput single-cell imaging performance (~10,000 cells/sec), this technique, termed single-cell biophysical fractometry, offers sufficient statistical power for delineating the cellular heterogeneity, in the context of classification of lung-cancer cell subtypes and tracking of cell-cycle progression. Further correlative fractal analysis shows that single-cell biophysical fractometry can enrich the standard morphological profiling depth and spearhead systematic fractal analysis of how cell morphology encodes cellular health and pathological conditions.
Sickle red blood cell derived extracellular vesicles activate endothelial cells and enhance sickle red cell adhesion mediated by von Willebrand factor
Authors: An Ran , Man Yuncheng , Cheng Kevin , Zhang Tianyi , Chen Chunsheng , Kucukal Erdem , Wulftange William J. , Goreke Utku , Bode Allison , Nayak Lalitha V. , Vercellotti Gregory M. , Belcher John D. , Little Jane A. , Gurkan Umut A.
Published: May 2022

Endothelial activation and sickle red blood cell (RBC) adhesion are central to the pathogenesis of sickle cell disease (SCD). Quantitatively, RBC-derived extracellular vesicles, REVs, are more abundant from SS RBCs compared with healthy RBCs (AA RBCs). Sickle RBC-derived REVs (SS REVs) are known to promote endothelial cell (EC) activation through cell signaling and transcriptional regulation at longer terms. However, the SS REV-mediated short term non transcriptional response of EC is unclear. Here, we examined the impact of SS REVs on acute microvascular EC activation and RBC adhesion at 2 hours. Compared with AA REVs, SS REVs promoted human pulmonary microvascular endothelial cells (HPMEC) activation indicated by increased von Willebrand Factor (vWF) expression. Under microfluidic conditions, we found abnormal SS RBC adhesion to HPMECs exposed to SS REVs. This enhanced SS RBC adhesion was reduced by vWF cleaving protease ADAMTS13 to a level similar to HPMECs treated with AA REVs. Consistent with these observations, studies in SS mice with implanted dorsal skin-fold chambers found hemin-induced stasis was inhibited by ADAMTS13. The adhesion induced by SS REVs was variable, and was higher with SS RBCs from patients with increased markers of hemolysis (LDH and reticulocyte count) or a concomitant clinical diagnosis of deep vein thrombosis. Our results emphasize the critical contribution made by REVs to the pathophysiology of SCD by triggering acute microvascular EC activation and abnormal RBC adhesion. These findings may help to better understand acute pathophysiological mechanism of SCD and thereby the development of new treatment strategies using vWF as a potential target.
An enhanced sensorless control based on active disturbance rejection controller for a PMSM system: design and hardware implementation
Authors: Lu Hao , Li Shengquan , Feng Bo , Li Juan
Published: May 2022

Purpose

This paper mainly aims to deal with the problems of uncertainties including modelling errors, unknown dynamics and disturbances caused by load mutation in control of permanent magnet synchronous motor (PMSM).

Design/methodology/approach

This paper proposes an enhanced speed sensorless vector control method based on an active disturbance rejection controller (ADRC) for a PMSM. First, a state space model of the PMSM is obtained for the field orientation control strategy. Second, a sliding mode observer (SMO) based on back electromotive force (EMF) is introduced to replace the encode to estimate the rotor flux position angle and speed. Third, an infinite impulse response (IIR) filter is introduced to eliminate high frequency noise mixed in the output of the sliding mode observer. In addition, a speed control method based on an extended state observer (ESO) is proposed to estimate and compensate for the total disturbances. Finally, an experimental set-up is built to verify the effectiveness and superiority of the proposed ADRC-based control method.

Findings

The comparative experimental results show that the proposed speed sensorless control method with the IIR filter can achieve excellent robustness and speed tracking performance for PMSM system.

Research limitations/implications

An enhanced sensorless control method based on active disturbance rejection controller is designed to realize high precision control of the PMSM; the IIR filter is used to attenuate the chattering problem of traditional SMO; this method simplifies the system and saves the total cost due to the speed sensorless technology.

Practical implications

The use of sensorless can reduce costs and be more beneficial to actual industrial application.

Originality/value

The proposed enhanced speed sensorless vector control method based on an ADRC with the IIR filter enriches the control method of PMSM. It can ameliorate system robustness and achieve excellent speed tracking performance.
Consumer purchase intention of intangible cultural heritage products (ICHP): effects of cultural identity, consumer knowledge and manufacture type
Authors: Zhang Mengxia , Guo Xixuan , Guo Xiaoling , Jolibert Alain
Published: May 2022

Purpose

Intangible cultural heritage products (ICHP) in this paper refer to the products made with handicrafts listed as intangible cultural heritage. The purpose of this paper is to examine the effects of consumer cultural identity and consumer knowledge on purchase intentions of ICHP, as well as the role of the perceived scarcity for such effects.

Design/methodology/approach

Three between-participants experiments were conducted to investigate the effect of cultural identity on purchase intention of ICHP and the underlying mechanism of the effect.

Findings

The results show that cultural identity has a positive influence on ICHP purchase intention, and this effect is stronger for consumers with higher level of consumer knowledge. Furthermore, perceived scarcity underlies such effect, but the scarcity account holds only for handmade ICHP, not for machine-manufactured products.

Practical implications

The current research suggests that ICHP should remain handmade to preserve their scarcity as a distinctive feature. Additionally, business practitioners handling ICHP should target consumers of high cultural identity, and/or provide iconic cues to activate their cultural identity situationally. Furthermore, it highlights the importance of consumer education programs about ICHP-related knowledge in enhancing the cultural identity effect.

Originality/value

This paper explores systematically the conditions and process of consumers' responses toward ICHP for the first time. Besides, it builds on accessibility-diagnosticity framework and provides novel knowledge about the functioning of consumer cultural identity. It also enriches our understanding of perceived scarcity from the supply side.
The new-normal challenges and IPD solutions: a Canadian case study
Authors: Rankohi Sara , Bourgault Mario , Iordanova Ivanka
Published: May 2022

Purpose

According to the construction literature, the number of projects applying integrated project delivery (IPD) principles is expected to increase in the new-normal era. However, given that the pandemic is not yet fully over, accurate and measurable data are not yet available. Also, there is a lack of empirical studies that could provide guidelines as to the application of IPD principles at the various stages of construction projects. Thus, the goal of this paper is to address this knowledge gap through case studies.

Design/methodology/approach

This paper follows a multi-step research methodology, namely, a literature review, case study and focus group discussions in the context of Canadian construction projects.

Findings

Based on the conducted literature review and focus group discussions, the authors identified: (1) new challenges in the various stages of the construction projects' life cycle, (2) their related proximity aspects (technological, organizational, geographical and cognitive) and (3) IPD principles that can address the identified challenges within their associated proximities. The results show that IPD relational principles can improve a project's organizational and cognitive proximities, while IPD digital integrative principles can enhance a project's geographical and technological proximities.

Originality/value

This study contributes to the theoretical checklists of challenges that the construction industry has experienced since the beginning of the pandemic, and to the practical guidelines of implementation of IPD principles to meet these challenges. The conducted case studies are timely and relevant, and their results provide new insights for key project stakeholders into the application of IPD to tackle new-normal challenges based on their proximity perspectives.
The effects of puffery in food packaging on consumers' responses via persuasion knowledge: role of food type and picture type
Authors: Huang Li-Shia , Huang Wan-Ju , Wu Yu-Han
Published: May 2022

Purpose

Food packaging pictures are one of the most important extrinsic cues for consumers to evaluate food products before purchasing. Over the past decades, marketers have used exaggerated pictures to attract consumers' attention, enhance their attitude toward a product and increase their purchase intention. This study examined the interplay of “puff-up” product picture, food type and picture type in influencing consumers' responses via persuasion knowledge.

Design/methodology/approach

The research comprises two 2 × 2 factorial experiments. Study 1 tested the interaction effect of puffery (high vs low) and food type (utilitarian vs. hedonic) on consumers' responses using two fictitious brands of prepared food, whereas Study 2 tested the interaction effect of puffery (high vs. low) and picture type (ingredients vs. cooked food) using a fictitious brand of Chinese delicacy.

Findings

Results demonstrated that the degree of picture puffery did not influence consumers' responses to utilitarian food and ingredient image. Conversely, consumers were sensitive to puffery when they see hedonic food and cooked-food image. Our findings also suggested that consumers' persuasion knowledge mediates the relationship between puffery and their responses.

Practical implications

The presented findings facilitate marketers to know consumers' attitude about food puffery pictures.

Originality/value

This research is one of the first efforts to empirically explore the influences of persuasion knowledge on food puffery pictures. The importance of this work is underscored by the fact that a growing number of visual exaggerations are adopted on food packaging.
Identifying and classifying the financial resilience measurement indices using intuitive fuzzy DEMATEL
Authors: Zahedi Javad , Salehi Mahdi , Moradi Mahdi
Published: May 2022

Purpose

The current study aims to identify and classify the financial resilience measurement indices using the intuitive fuzzy approach.

Design/methodology/approach

The present study aims to identify and classify firms' indices of financial resilience measurement using the Fuzzy–Delphi combined method and the intuitive fuzzy DEMATEL technique with interval values. For the study and the literature review, 29 financial resilience indices were identified, and 12 were finalised after screening and localisation. Next, the selected indices were classified into two groups of influencing and being influenced, and the significant range of each one was determined. Finally, the executive and research suggestions were presented based on the obtained results.

Findings

The study results indicate a higher significance level of redundancy and visibility in financial resilience.

Originality/value

The present study is the pioneer study to assess, identify and classify the contributing indices to financial resilience.
Factors influencing buildability assessment implementation in the Nigerian construction industry
Authors: Osuizugbo Innocent Chigozie , Okolie Kevin Chuks , Oyeyipo Opeyemi Olanrewaju
Published: May 2022

Purpose

Due to the need to enhance the buildability of building designs in building construction industry, a buildability assessment framework was developed for use in Nigeria. This paper aims to investigate and determine the factors influencing buildability assessment implementation in the Nigerian construction industry with the view to improving buildability of building designs. To address the aim, this study will provide answers to the following research question: what are the factors hindering and supporting the implementation of buildability assessment in the Nigerian construction industry?

Design/methodology/approach

Survey research method was adopted for the study. Questionnaires were administered to purposively selected group of architects, engineers, builders and quantity surveyors involved in construction project delivery within the client, consulting and contracting organisations in Nigeria. A total of 368 questionnaires were distributed among the sampled participants, out of which a total of 219 representing 60% were sufficiently filled and returned. Data collected were analysed using inferential and descriptive statistics.

Findings

The results revealed owner’s commitment, clients’ awareness of the benefits of conducting buildability assessment on building design, unity among different professionals in the construction industry, designers consider buildability important, adequate coordination among different design disciplines, adequate channel for coordination and communication between designers and constructors at the design stage and adequate support from the government as the topmost seven factors supporting buildability assessment implementation in the construction sector of Nigeria. Second, the study revealed that poor coordination among different design disciplines, lack of buildability assessment awareness, design review pattern where construction personnel (builders) are invited to assess the building production information, unwillingness to invest extra money and effort during the early stage of project and designers value aesthetics and functionalities more than buildability in their designs are the topmost five factors hindering buildability assessment implementation in the Nigerian construction industry.

Originality/value

The study provides detailed insights into the factors supporting and hindering buildability assessment implementation in the Nigerian construction industry. The findings indicate the need to enlighten principal stakeholders in construction about buildability and the outcome of the buildability assessment tool. This information can motivate principal stakeholders in implementing and practising buildability assessment.
It’s not justice if it’s not for all: cross-level interaction of interactional justice differentiation and supervisory justice on psychological safety and conflict
Authors: Afshan Gul , Serrano-Archimi Carolina , Riaz Amir , Kashif Muhammad , Khuhro Mansoor Ahmed
Published: May 2022

Purpose

Building on social exchange and deontic justice theory, this study aims to examine the relationship between supervisory justice (i.e. interactional, procedural and distributive) and conflict (i.e. relationship, process and task) through subordinates’ perceptions of psychological safety. Moreover, the authors hypothesize that interactional justice differentiation (IJD) within a workgroup at the group level interacts with supervisory justice at the individual level, affecting subordinates’ psychological safety and conflict.

Design/methodology/approach

Data were collected using a survey conducted among 378 service sector (banks, hospitals and universities) employees working under 54 supervisors.

Findings

Multi-level data analysis demonstrates that supervisory justice positively influences psychological safety, negatively affecting conflict. Moreover, psychological safety mediates the supervisory justice–conflict relationship. A cross-level interaction partially supports the conditional indirect effect of IJD in the supervisory justice–conflict relationship via psychological safety.

Originality/value

Following moral principles based on a deontic perspective, this study stretches the understanding of how to treat employees in a workgroup while creating a healthier working environment to minimize conflict fairly. This study extends the limited research on supervisory justice by conceptualizing employees’ perceptions of justice beyond an individual-level analysis.
Corporate social responsibility and corporate innovation efficiency: evidence from China
Authors: Yuan Ling , Zheng Li , Xu Yong
Published: May 2022

Purpose

This study aims to analyse the impact of corporate social responsibility (CSR) on corporate innovation efficiency and the mechanism underlying this effect.

Design/methodology/approach

Data of non-financial listed companies operating in China from 2010 to 2019 were employed. Dual fixed-effects and dynamic panel models were used to explore the relationship between CSR and corporate innovation efficiency, and analyse its heterogeneity.

Findings

The researchers found that CSR reduces innovation efficiency in China. Further, (1) when enterprises conduct CSR to obtain excess returns, it is easy to form excess goodwill; (2) under the pressure of the government and society, enterprises passively assume CSR, thereby crowding out R&D funds; and (3) regardless of whether companies in the high-tech industry actively or passively assume social responsibilities, CSR will not have a significant impact on their innovation efficiency.

Research limitations/implications

The sample of this research is limited to Chinese A-share listed companies and lacks consideration for small and medium-sized enterprises. Therefore, whether the conclusions of this article are applicable to small and medium-sized enterprises or family enterprises needs further verification.

Practical implications

The research explores the intrinsic motivation and possible consequences of CSR from the dual perspectives of corporate active and passive.

Social implications

The ultimate goal of a firm is to make a profit. In practice, few enterprises pay without any return. Perhaps some companies actively assume social responsibilities in order to obtain greater benefits, while passively assume social responsibilities due to oppression.

Originality/value

This study analyses the impact of CSR on corporate innovation efficiency from both active and passive perspectives. The results have important implications for government officials and entrepreneurs.
Surviving intimate partner violence and disaster
Authors: Cannon Clare E.B. , Ferreira Regardt , Buttell Fredrick , O'Connor Allyson
Published: May 2022

Purpose

Few studies investigating disaster have examined the risks associated with surviving both disaster and intimate partner violence (IPV). IPV is psychological or physical abuse in a personal relationship. Using an intersectional approach, the purpose of this study is to investigate contributions to and differences in perceived stress and personal resilience during the COVID-19 pandemic among a sample of predominantly female-identified IPV survivors (n = 41) to examine risks associated with this vulnerable population during disaster.

Design/methodology/approach

Using a structured interview guide, IPV survivors were interviewed regarding their perceived stress (i.e. perceived stress scale), personal resilience, (i.e. Connor Davidson Resilience Scale), type of violence experienced (i.e. physical violence), COVID-19-related stressors (i.e. loss of income due to the pandemic) and relevant socio-demographic characteristics (i.e. race).

Findings

These interviews indicate that participants exhibited low levels of resilience and a moderate amount of stress exposure highlighting risk factors associated with experiencing personal violence during disaster.

Originality/value

At the height of their need for support and assistance, the disaster generated additional rent and nutritional stress compounding the pressures violence survivors face. These findings suggest those who are socially vulnerable due to violence need structural support services to cope with disaster and violence-related stresses.
Understanding the influence of business strategy in corporate social responsibility: evidence from Chinese firms in Africa
Authors: Getele Gutama Kusse , Arrive Tsitaire Jean , Ruoliu Xiong
Published: May 2022

Purpose

This study aims to understand better how business strategies impact a company’s corporate social responsibility (CSR).

Design/methodology/approach

In this research, two categories of business strategy are proposed, and partial least squares structural equation modelling (PLS-SEM) was used to test the research model using a sample of 150 valid surveys data from the Chinese manufacturing firms industry in Africa.

Findings

This study indicates business strategy in terms of real support and development approach plan in the Chinese manufacturing industry has a crucial influence on CSR effectiveness. Business strategy leads to effective CSR practices by adding value to firm products, services, marketing strategies and technological investment.

Practical implications

Companies can use a support strategy for effective CSR to improve corporate social performance. The study expands upon previous insights into corporate leaders enhancing their CSR strategy because it may successfully contribute to environmental preservation.

Social implications

This research mobilized and found academic gaps in business strategy regarding real support and development approach; it is necessary to combine the impacts of business strategy at multiple levels of analysis to explain the expansion of CSR to integrate the stakeholder theory.

Originality/value

This study offers a deeper perspective and provides empirical evidence of a better understanding of CSR effectiveness by emphasizing the role of business strategy. Effective CSR implementation requires integrating the influences of company strategy and real support at multiple levels of analysis to explain CSR dispersion.
Implementing organisational change in a digitalising facilities management organisation through stewardship interventions
Authors: Johannes Koos , Voordijk Hans , Wakkee Ingrid , Aranda-Mena Guillermo
Published: May 2022

Purpose

While digitalisation requires facilities management (FM) organisations to change at an increasing rate, little is known about the mechanisms that create ownership and enable individuals to implement changes in everyday FM practice. In this study, these mechanisms are explored from a stewardship perspective. The purpose of this paper is to provide insights into the dynamics of organisational change in FM by analysing how stewardship behaviour leads to change.

Design/methodology/approach

A process model for implementing organisational change is constructed, based on existing theoretical insights from stewardship and intrapreneurship literature. The model is evaluated in a case study through analysis of critical events. Interviewing was the key data collection method.

Findings

The process model gives an event-driven explanation of change through psychological ownership. Analysis of multiple critical events suggests that the model explains intra-organisational as well as inter-organisational change. The case data further suggests that, compared with intra-organisational change, tailored relational and motivational support is more important for inter-organisational change because of the higher risks involved. Job crafting emerged as an unanticipated finding that offers interesting prospects for future FM research.

Practical implications

The process model offers guidance for leaders in FM organisations on providing tailored support to internal and external employees during periods of organisational change.

Originality/value

Stewardship and intrapreneurship are combined to provide insights on organisational change in FM. The study demonstrates how intrapreneurial behaviour and stewardship behaviour can be linked to create innovation within and between organisations.
Requested to do right things excessively: how citizenship pressure/future focus influence health-related work outcomes in health organizations during the pandemic
Authors: Lan Junbang , Gong Yuanyuan , Yuan Bocong
Published: May 2022

Purpose

Public health practitioners face citizenship pressure when requested to engage in more extra-roles behaviors during the pandemic. The purpose of the study is to reveal the potential influence mechanism of citizenship pressure on the health and work outcomes of practitioners.

Design/methodology/approach

The authors completed a three-wave survey from a public healthcare organization during the coronavirus disease 2019 (COVID-19) delta-variant epidemic.

Findings

Results of polynomial regression and response surface showed that increased (versus decreased) and consistently high (versus low) level of citizenship pressure induced citizenship fatigue, which in turn increases negative affect/turnover intention. These negative effects of citizenship pressure are weaker among practitioners with a higher level of future focus.

Practical implications

Providing counseling service to health care practitioners in adopting a future time perspective of citizenship behaviors is important for public health organizations.

Originality/value

This study is among the earliest attempts to reveal the potential dark side of excessive request of conducting organization citizenship behavior which is more commonly seen within public health organizations in the context of pandemic.
Measuring halal logistics implementation
Authors: Susanty Aries , Puspitasari Nia Budi , Silviannisa Silviannisa , Jati Sumunar
Published: May 2022

Purpose

This study aims to identify the suitable indicators and their scale for measuring the level of logistic halal implementation and then develops the measurement system based on those indicators and scales. Moreover, this research also applies the measurement system in food, beverage, and ingredient companies.

Design/methodology/approach

This study collected data through web-based closed questionnaires and short telephone interviews. This study succeeded in obtaining seven valid data sets from filling out validation and analytical hierarchy process questionnaires by a panel of experts. This study also obtained 97 valid data sets from filling out the questionnaire about the current condition of each indicator related to halal logistics (HL) implementation. Then, the framework for measuring HL implementation was designed based on the multi-attribute value theory approach.

Findings

The aggregate value of HL implementation in ingredient companies belongs to the excellent implementation category. In contrast, the aggregate value of HL implementation in food and beverage companies only belongs to the good implementation category. Then, according to the size of the company, the large-sized companies have the higher means of the aggregate value of HL implementation for preferred indicators than small- and medium-sized companies. However, all size companies belong to the good implementation category.

Research limitations/implications

This research has several limitations. The preferred indicators are only measured by the Likert scales. Future research may benefit from inducing the qualitative approaches to measure the condition of each indicator better. Secondly, this research only consisted of 97 food, beverages and ingredients companies. Thirdly, this research only measured the HL implementations to a particular sector or industry. Future research could benefit from replicating the work in similar and dissimilar contexts, adding the sample size and comparing the level of HL implementation between Muslim and non-Muslim companies, and moreover, enhance the measurement of HL implementation by including consumers and other actors involved, such as the government.

Practical implications

This research provided a basis for helping the government and policymakers understand and evaluate non-performing indicators in HL implementation before formulating several actions.

Social implications

Understanding the current HL implementation conditions could facilitate a more effective response in designing some appropriate alternative actions.

Originality/value

This research contributed to measuring HL implementation with a new indicator, a new scale and a new object in an empirical case of food, beverages and ingredient companies in Indonesia.
Supply chain risk management: manufacturing- and service-oriented firms
Authors: Truong Huy Quang , Hara Yoshinori
Published: May 2022

Purpose

A risk, when it occurs, causes negative effects on outputs. Typically, risks are not independent as multiple risks occur simultaneously. The purpose of this paper is to compare the impact various risks have on the performance of manufacturing-oriented and service-oriented firms from a supply chain (SC) perspective.

Design/methodology/approach

First, SC risks were identified and classified into two criteria: context and probability. Then, the different characteristics between manufacturing- and service-oriented firms were distinguished by the theory of goods-dominant logic (GDL) and service-dominant logic (SDL). Structural equations modeling and multiple-group analysis were then used to validate research hypotheses and compare the two groups.

Findings

The empirical evidence, gathered from the Vietnamese construction sector, indicated that in a serious situation all of the five risks proposed occur at the same time, thus the remarkable 87.1% variance in SC performance was explained. Furthermore, this rate is significant when the two groups are compared: manufacturing-oriented firms (88.3 percent) and service-oriented firms (85.6 percent), implying that risks in the manufacturing-oriented group have a greater effect on SC performance. While manufacturing-oriented companies should pay close attention to the operational and demand risks that adversely affect SC performance, they should treat information risk as an opportunity to improve. Service-oriented companies, however, need to manage supply risk which, in their case, can be attributed to a 51.2 percent variance in SC performance. Moreover, service quality can also be improved remarkably if information risk is well managed.

Research limitations/implications

This study provides a detailed picture of the relationship between risks and performance in the SC. Risks are illustrated as affecting the SC performance simultaneously, (not separately) and so the approach outlined here will give firms a comprehensive view of their SCs and provide guidelines for predicting the impact risks will have on the SC performance. Moreover, by comparing manufacturing- and service-oriented firms, a thorough overview of risk behaviors is provided and appropriate solutions for each type of company can be determined.

Originality/value

The “novelty of approach” of this study is in applying GDL and SDL theory to classify the manufacturing-oriented and service-oriented firms. The different characteristics between the two groups are identified and explained in terms of resources, value, network, effectiveness vs efficiency and communication, thus providing an insight into risk management activities in the SC network.
Undertaking qualitative research on trauma: impacts on researchers and guidelines for risk management
Authors: Dickson-Swift Virginia
Published: May 2022

Purpose

Undertaking qualitative research exploring experiences of trauma can be challenging for all members of a research team. The aim of this article is to document the key challenges faced by researchers and to provide an overview of the key guidelines and processes that have been developed.

Design/methodology/approach

Drawing on a range of empirical and published reflective accounts over the past 20 years, this article documents the key challenges researchers undertaking qualitative research face. These accounts are synthesized for the reader and an overview of research guidelines provided.

Findings

Qualitative researchers and members of the research team (including research assistants, transcriptionists and research supervisors) undertaking trauma research face many challenges including physical and emotional manifestations. Despite the development of a range of guidelines and protocols, formalized processes are still lacking. Researchers need to be supported to consider the impact of the research on themselves and others within the research team and include these assessments in their ethics and funding applications.

Research limitations/implications

Researching trauma (like many other topics) can be challenging for researchers and it is important that we ensure researchers are not harmed in the research process. Adopting guidelines like those presented in this paper and encouraging formalized processes for researcher risk assessments are paramount.

Originality/value

Discussions about risk to researchers when undertaking qualitative research have existed for many years but they have not always resulted in acknowledgement of development of supportive processes. By bringing together empirical research and reflective accounts from a range of disciplines the issues researchers face can become more visible.