bluuebunny/crossref_metadata_2025 huggingface dataset:
Real World Patient-reported Outcomes in HIV-infected Adults Switching to EVIPLERA®, Because of a Previous Intolerance to cART. PRO-STR Study
Authors: Podzamczer D. , Rozas N. , Domingo P. , Miralles C. , den Eynde E. Van , Romero A. , Deig E. , Knobel H. , Pasquau J. , Antela A. , Clotet B. , Geijo P. , de Castro E. Rodríguez , Casado M.A. , Muñoz A. , Casado A. , for the PRO-STR STUDY GROUP
Published: February 2019

Background:

To investigate the impact of switching from stable Combined Antiretroviral
Therapy (cART) to single-tablet regimen (RPV/FTC/TDF=EVIPLERA®
/COMPLERA®) on patient-reported outcomes in HIV-infected adults who cannot tolerate previous cART, in a real-world
setting.

Methods:

PRO-STR is a 48-week observational, prospective, multicenter study. Presence and magnitude
of symptoms (main endpoint), health-related quality-of-life (HRQoL), adherence, satisfaction
with treatment and patient preferences were assessed.

Results:

Three hundred patients with 48-week follow-up, who switched to EVIPLERA® (mean age:
46.6 years; male: 74.0%; 74.7% switched from a non-nucleoside reverse-transcriptase-inhibitor,
25.3% from a protease inhibitor + ritonavir) were included. There was no statistical difference in
median CD4+ cell count (baseline: 678.5 cells/mm3; 48-week: 683.0 cells/mm3) neither in virological
suppression (≤50 copies/mL) (baseline: 98.3%; 48-week: 95.3%). The most frequent reasons for
switching were neuropsychiatric (62.3%), gastrointestinal (19.3%) and biochemical/metabolic
(19.3%) events. Only 7.7% of patients permanently discontinued therapy. At 48-week, all outcomes
showed an improvement compared to baseline. Overall, there was a significant decrease (pvalue≤
0.05) in number and magnitude of symptoms, while HRQoL, satisfaction and adherence
improved significantly. Most patients prefered EVIPLERA® than previous cART. According to the
type of intolerance, HRQoL was improved, but only significantly in patients with neuropsychiatric
and gastrointestinal symptoms. Adherence improved significantly in patients with metabolic
disturbances and satisfaction with EVIPLERA® was higher in the three groups.

Conclusion:

Switching to EVIPLERA® from non-nucleoside reverse-transcriptase-inhibitor or protease
inhibitor-based regimens due to toxicity, improved the presence/magnitude of symptoms,
HRQoL, and preference with treatment. EVIPLERA® maintained a virological response, CD4+ cell
count and maintained or improved adherence.
Potential Role of Regulatory T Cells in Mother-to-Child Transmission of HIV
Authors: Kessler Peter A.
Published: February 2019

Background:

Mother-to-child transmission of HIV-1 occurs in a minority of HIVinfected mother-infant pairs, even without any interventions. The mechanisms that protect the majority of HIV-exposed infants from infection are unclear. T regulatory cells (Treg) have important immunomodulatory functions, but their role in the fetus as well as in mother-to-child transmission of HIV is under-studied.

Methods:

We studied available cryopreserved peripheral blood mononuclear cells from HIVexposed infants from the Breastfeeding, Antiretrovirals and Nutrition (BAN) Study cohort in Malawi: 64 infants were HIV-uninfected and 28 infants were HIV-infected at birth. We quantified the frequency of Treg cells (CD4+CD25+FoxP3+), and activated CD4+ and CD8+ T cells (CD38+ HLADR+) by flow cytometry at birth, 6 weeks and 6, 9 and 12 months of age. Descriptive statistics were performed to describe the distributions of these lymphocyte markers according to the HIV infection status; and Student’s t tests and Wilcoxon-Rank Sum tests were performed to compare HIVinfected and uninfected infants.

Results:

T cell activation increased rapidly in the first 6 weeks of life, more pronounced on CD8+ T cells; a further increase in activation was observed at the time of weaning from breastfeeding at 6 months of age. In contrast, the frequency of Treg was stable over the first 6 weeks of life (median, 0.5%), slightly decreased between 6 weeks and 6 months (median at 6 months, 0.3%) and then slightly increased between 6 months (time of weaning) and 12 months of age (median, 0.45%). HIVinfected infants had significantly higher frequencies of activated T cells than uninfected infants (P < 0.01). At the time of birth, HIV-exposed uninfected infants had higher levels of Treg, compared to infants infected in utero, even though this did not reach statistical significance in this small sample size (P = 0.08).

Conclusion:

This study provides initial evidence that Treg may play a role in preventing mother-tochild transmission of HIV, likely by suppressing immune activation in the fetus and infant, and needs to be substantiated in a larger study. Better characterization of the role of Treg in fetal and neonatal immunity may provide a valuable complementary approach to achieve eradication of mother-to-child transmission of HIV.
Characterization of Chemical Compounds and Antioxidant Activity of Centaurea solstitialis sp. schouwii (DC.) Q. et S. (Asteraceae)
Authors: Aliouche Lamia , Mosset Paul , León Francisco , Brouard Ignacio , Benayache Samir , Sarri Djamel , Benayache Fadila
Published: February 2019

Background:

The antioxidant activity and the total phenolic and flavonoid contents of the derived extracts (chloroform, ethyl acetate and n-butanol) of the 70% hydroalcoholic extract of the aerial parts of Centaurea solstitialis growing in Algeria was assessed. The active extracts were selected for phytochemical investigations.

Methods:

The antioxidant capabilities of the extracts were assessed using 1, 1-diphenyl-2- picrylhydrazyl radical (DPPH•) scavenging and Cupric Ion Reducing Antioxidant Capacity (CUPRAC) assays. Butylhydroxyanisole (BHA), butylhydroxytoluene (BHT) and α –tocopherol were used as positive controls. The total phenolic content and total flavonoid content of the extracts were determined as gallic acid equivalents and quercetin equivalents, respectively. Chromatographic methods were used to isolate the secondary metabolites and spectrometric and spectroscopic methods were used to determine their chemical structures.

Results:

The ethyl acetate extract exhibited the highest antioxidant activities followed by the n-butanol extract. The highest phenolic and flavonoid contents were found in the n-butanol extract. Phytochemical study of the ethyl acetate and n-butanol extracts led to the isolation of an undescribed guaianolide named 3-(4-hydroxybenzoyl)-cynaratriol and a known sesquiterpene lactone along with three known flavonoid glycosides. Their structures were established by spectral analyzes mainly high resolution electrospray ionisation mass spectrometry (HR-ESIMS) and 1D and 2D nuclear magnetic resonance experiments.

Conclusion:

The extracts of aerial parts of C. solstitialis showed significant antioxidant activities. An undescribed sesquiterpene lactone and four known secondary metabolites were isolated from the most active extracts.
Telomere DNA Binding, Cleavage and Anticancer Activity of [Cu(phendione)(Hpyramol)Cl]
Authors: Maheswari Palanisamy Uma , Duraisamy Renuga , Kanagavel Murugesan , Natarajaseenivasan Kalimuthusamy , Meera Sheriffa Begum Kadhar Mohamed , Kandasamy Ruckmani
Published: February 2019

Background:

The ligand Hpyramol is a redox active, which on coordination with Cu(II) cleaves DNA without any added reductant. Another ligand phendione is known for its wide application towards anticancer activities. We combined the ligands with CuCl2 to have an intercalation moiety and a redox active ligand in participation towards telomere DNA cleavage and anticancer activity.

Objective:

In this study, our aim is to interact it with Human telomere DNA and to see their effects on cancer cells.

Methods:

The complex [Cu(L)(L’)Cl] has interacted with the human telomere DNA sequence (TTAGGG), HTelo20. The HTelo20 was stabilized under both parallel and antiparallel G-quadruplex conformations and the complex [Cu(L)(L’)Cl] has interacted followed by circular dichroism spectroscopy and gel electrophoresis.

Results:

The parallel G-quadruplex and randomly coiled conformations of HTelo20 were easily cleaved than the anti-parallel G-quadruplex conformation. The nature of DNA cleavage was found to be oxidative rather hydrolytic. The formation of phenoxyl radical species under electrochemical and controlled potential electrolysis conditions by the complex [Cu(L)(L’)Cl] proves the possibility of oxidative nature of DNA cleavage. The comet assay also proves the DNA cleavage induced by the complex [Cu(L)(L’)Cl] inside the nucleus of HeLa cancer cells.

Conclusion:

The complex [Cu(L)(L’)Cl] was tested for anticancer activity, induced by ROS and DNA cleavage. The IC50 values resulted in nanomolar concentrations with selected cancer cell lines. Relatively the Cu complex shows less toxicity with the normal cell line L132.
Dar voz aos cidadãos: Debate eleitoral na elaboração da Constituição vintista
Authors: Fernandez Hugo Matos
Published: February 2019

A implantação do liberalismo e a consagração do princípio da soberania nacional através dos mecanismos darepresentação política significaram não só o envolvimento dos cidadãos na governação de cada país por via essencialmenteeleitoral – na escolha dos representantes mandatados para exercer o poder em nome do interesse coletivo – como aconsideração igualitária da condição cívica, atestando simultaneamente a passagem do súbdito a cidadão e a assunçãodeste último enquanto indivíduo portador de iguais direitos e deveres. É neste contexto teórico que enquadraremos a análiseda problemática eleitoral na vigência do período inicial do liberalismo português (1820-1823), focando-nos na discussãoparlamentar que levou à elaboração da nossa primeira Constituição (1822) e à determinação do âmbito ou extensão socialdo direito de voto então consagrado.
A Formação dos Campos Políticos na Queda dos Regimes Autoritários. Portugal e Itália: Paradigmas de Recrutamento Político
Authors: Adinolfi Goffredo
Published: February 2019

O problema das elites políticas é de certeza uma das questões centrais para o estudo do funcionamento dos sistemas políticos. Crucial, em nosso entender, a relação entre crise de regime, transição e recrutamento político. Neste artigo são abordados esses processos em dois países do Sul da Europa: Itália e Portugal. O objectivo é ver como na única instituição que nunca deixou de existir - o Governo - se recompuseram as fracturas nos períodos de conjunturas críticas. Utilizando uma metodologia quantitativa - que leva em consideração variáveis de carácter político (filiação partidária, percurso nas instituições) - e qualitativa (cargos chave nos ministérios, biografias), percorremos o processo de re-construção da elite ministerial durante e após a transição. A investigação põe em relevo a dificuldade em encontrar elementos comuns entre estes dois países, sendo no caso italiano o campo político fortemente dissociado da sociedade civil e, no caso português, composto em grande parte por ministros alheios ao profissionalismo político tout court. Os dados evidenciam como as tradições de recrutamento político nacional são factores mais explicativos do que os possíveis paradigmas "Sul-europeus". O único elemento comum importante entre Itália e Portugal é, em momentos de grande crise, a confiança dos actores políticos em jogo nas altas patentes militares, elemento que não nos parece caracterizar unicamente estes dois países.
A 'ardente paciência': reconstruir o político numa era global de compressão
Authors: Rocha-Cunha Silvério
Published: February 2019

Este texto pretende pensar os dilemas políticos da cidadania moderna numa era global, quando a esperança dos povos e possibilidades históricas se encontram subordinadas a uma ideia débil de democracia.
La Teoria de A. Negri. Tra "Pensare Nella" e "Pensare Sulla" Congiuntura
Authors: Viparelli Irene
Published: February 2019

Il presente articolo si propone di reflettere sull' evoluzione della teoria di Negri, dagli scritti "marxiani" degli anni Sessanta e Settanta, fino all´último testo, scrito in collaborazione con M. Hardt, Commonwealth. La nostra ipotese à che sia possibilecogliere la logica di sviluppo della teoria di Negri soltanto ipotizzando la sua apparteneza alla tradizione del pensiero rivoluzionario; una tradizione che si caratterizza per líntimo legame tra sviluppo teorico e movimento ciclico del capitalismo. Utilizzando il lessico althusseriano, abbiamo definito tale dinamica di svilluppo del pensiero rivoluzionario come alternarsi "pensare nella" e del "pensare sulla" congiuntura. La prima parte dell´articolo è consacrata all´analisi dei testi del cosiddetto "perioso operaista": tali testi, sia per la loro subordinazione alla specifica congiuntura italiano degli anni sessanta e alla crisi internazionale degli anni settanta, sia per la loro ricerca di una strategia politica adeguata alla lotta di classe in questo specifico contesto, non possono che essere considerati come espressione emblematica di un "pensare nella" conguintura. Nella seconda parte ci siamo occupati della produzione teorica di Negri, dagli scritti degli anni Ottanta fino a Multitude, mostrando come l'obiettivo fondamentale sia quello di portare "alla forma del concetto" una serie di intuizioni teoriche sviluppate nel corso della "riflessione congiunturale". Infine, nell'ultima parte, abbiamo formulato l'ipotesi che, con Commonwealth, si compia un nuovo "dislocamento teorico": la crisi finanziaria del 2008 impone a Negri di abbandonare nuovamente l'"astratto" terreno della riflessionare teorica, per immergersi nella "concretezza" della riflessione congiunturale, al fine di definire una strategia rivoluzionaria adeguata alle forze produttive contemporanee, alla Moltitudine biopolitica.
The US in Justice. Liberal Criteria for Exclusion and Inclusion
Authors: Ivan Juárez Mario
Published: February 2019

The current debate between national and cosmopolitan liberalism has reached a dead-lock because of the importance they both award to culture in the realm of justice. This paper analyzes both proposals considering only the extent to which they achieve liberal objectives. On the one hand, cosmopolitanism reveals to be illiberal: Sen argues that the only way to warrant plurality is through an external eye in order to avoid dangerous localisms, which cancels cosmopolitanism´s proposal as it is based on a unique metaphysical conception of the human being. On the other hand, national liberalism may occlude justice as fairness if the cultural and essentialist identity that shapes the state creates hurdles for distributing wealth within the national society: albeit nationalism has largely been efficient as the basis for fairness, with the advent of free-trade economy, the nation-state has lost the means to control its peolpe´s future.This paper holds the hypothesis that it is not cultural sympathies that allow voluntary cooperation within the state, but it is the possibility of justice that creates common sympathies within the population. Therefore, beyond any cultural considerations, a liberal state must be defined only by the extent to which it fulfills the ethical, material and spatial requirements of justice as fairness.Area: Political Theory.Keywords: Liberalism, Transnational Justice, Nation-State, Cosmopolitanism, Justice as fairness.
Géstion de la Movilidad Humana de Acuerdo com la Externalización de Fronteras: los Procediementos del Acuerdo de Readmisión entre España e Mauritania
Authors: Trejo Peña Alma Paola , Fernández Feijoo Elisa Carolina
Published: February 2019

El objetivo de este trabajo es dar a conocer lo que subyace en la política migratoria española a la hora de gestionar los flujos de entrada de extranjeros. La metodología utilizada para llevar a cabo este estudio se basa en un análisis descriptivo tanto de la política española como de la europea respecto al control de la migración. En la primera parte del documento se muestra cómo la gestión de las fronteras es una estrategia para controlar la migración irregular a nivel mundial. La segunda, se refiere a la exposición de un caso concreto basado en el análisis del acuerdo bilateral de readmisión entre España e Mauritania. Se trata de abordar dos vertientes, por un lado, la del control y por outro, de la cooperación para estos fines a través del principio de reciprocidad.
Prohibiting Amendment: the Use of Absolute Rigidity in the Constitutions of the Countries of the World
Authors: Anckar Dag
Published: February 2019

Constitutional amendments are as a rule enacted by special procedures that are more stringent than the procedure required of ordinary legislation. Some constitutions even make use of entrenched clauses which restrict in full the use of amendment; such constitutions, then, introduce what is called in this study "absoluty rigidity" (AR). Mapping the use of AR in the constitutions of countries of the world, this study shows that about one third of the countries have introduced for defined issues and principles a ban on amendment, differences between regions of the world being fairly small and the overall pattern therefore being global rather than territorial. However, more than countries in other regions, African countries are frequent AR-users. In regards to the question why some states resort to AR whereas others do not, findings are that democracies are not as frequent AR-users as are non-democracies; furthermore, diffusion stands out as an important explanatory factor, as evident from an inserted case study of former British colonies which indicates that a distaste of Britain for AR has indeed been transformed to the colonies, almost all of which have avoided the method. Concerning matters that enjoy AR-protection, territorial integraty, fundamental rights and freedmons, and republican and democratic forms of government are among the most frequent. A fair amount of the AR-entrenchements are in an empty-words category, as they are violated, even flagrantly, by the very states that have installed them.Key-words: Comparative law, constitution-making, constitutional rigidity, democratic politics.
The Real Tools of Magic: Pamphile’s Macabre Paraphernalia (Apuleius, Met. 3,17,4-5)
Authors: Costantini Leonardo
Published: February 2019

This study aims to shed new light on the references to the materiality of magic in the description of the witch Pamphile’s laboratory at Apul. Met. 3,17,4-5. Through comparing this passage with earlier descriptions of magical paraphernalia in Horace, Lucan, and Petronius and by drawing parallels with non-literary evidence – especially the Papyri Graecae Magicae and the Defixionum Tabellae – it will be shown how Apuleius borrows from the material culture of magic to provide his readership with an exceptionally realistic and gruesome account. Leonardo Costantini is a postdoctoral research fellow at the Albert-Ludwigs-Universität Freiburg, where he is working on a new commentary on Apuleius’ Metamorphoses 3 to complete the GCA series. His research focuses on the literary and textual aspects of Apuleius’ literary works, the ancient novels, writings of the Second Sophistic, taking into account their socio-cultural background with particular attention to Greco-Roman magic. A reworked version of his doctoral dissertation, devoted to Apuleius’ Apologia and magic, is forthcoming at De Gruyter, series: Beiträge zur Altertumskunde.
St. Paul’s Letters and Classical Culture
Authors: Smith Warren S.
Published: February 2019

Paul in his Letters drew on conventions that would have been familiar to anyone receiving a rudimentary Greek education. The persona used at the end of Romans 1 to denounce the sinners in contemporary culture is based on the alazon or boastful man familiar from satire and the diatribe philosophical style of Bion, Seneca, and later Epictetus. The persona in Romans 7 who prays to be delivered from “this body of death” goes back to Greek tragedy and can be paralleled in the tragic tone of such poets as Ovid and Catullus. The beautiful hymn to love in I Corinthians 13 goes back to Socrates’ speech in Plato’s Symposium and also owes much to the pattern for an  encomium used  in Aristotle’s Rhetoric and followed by Isocrates and Cicero. Paul’s discussion of “the Married and Unmarried Man” in I Corinthians 7 and “The Weak Man’ in Romans 14 are consistent with stereotypes introduced by Aristotle and Theophrastus and found on stage in comedies such as “The Bad Tempered Man.” All these passages are based on cultural commonplaces that would have made Paul’s arguments come alive to a Greek speaking audience.Warren S. Smith is a retired Professor of Classics at the University of New Mexico. Among his books is Satiric Advice on Women and Marriage from Plautus to Chaucer (Michigan, 2005). His articles on Apuleius and the New Testament have appeared before inAncient Narrative. His church service includes teaching stints in the Philippines and Kenya, and  weekly visits to a prison in Los Lunas, N.M.
Jagadguru Adi Shankaracharya – A Source of Learning Leadership Traits and Skills for Sustainable Management Practices
Authors: Kinkhabwala Bhavesh A. , Gor Ravi
Published: February 2019

During the 8th century when a chaotic situation prevailed in the society, the very subsistence of the Hindu religion, culture and traditions were in peril and more proximate to vanish. At that time a great logician, a
profound stalwart named Shankar, who left the world at an early age of 32, with an accolade of “Bhagwadpad Jagadguru Adi Shankaracharya” and referred as Adi Shankara or Shankaracharya brought a radical transmutation in the society. This paper
attempts to study and develop an insight from the life, events, teachings, lineage and practices of “Jagadguru Shankaracharya” and drawing out the leadership traits, style and skills for sustainable management practices which is the need of an hour.
Digital Games and Mindfulness Apps: Comparison of Effects on Post Work Recovery
Authors: Collins Emily , Cox Anna , Wilcock Caroline , Sethu-Jones Geraint
Published: February 2019

Background

Engagement in activities that promote the dissipation of work stress is essential for post work recovery and consequently for well-being. Previous research suggests that activities that are immersive, active, and engaging are especially effective at promoting recovery. Therefore, digital games may be able to promote recovery, but little is known about how they compare with other popular mobile activities, such as mindfulness apps that are specifically designed to support well-being.

Objective

The aim of this study was to investigate and compare the effectiveness of a digital game and mindfulness app in promoting post work recovery, first in a laboratory setting and then in a field study.

Methods

Study 1 was a laboratory experiment (n=45) in which participants’ need for recovery was induced by a work task, before undertaking 1 of 3 interventions: a digital game (Block! Hexa Puzzle), a mindfulness app (Headspace), or a nonmedia control with a fidget spinner (a physical toy). Recovery in the form of how energized participants felt (energetic arousal) was compared before and after the intervention and how recovered participants felt (recovery experience) was compared across the conditions. Study 2 was a field study with working professionals (n=20), for which participants either played the digital game or used the mindfulness app once they arrived home after work for a period of 5 working days. Measures of energetic arousal were taken before and after the intervention, and the recovery experience was measured after the intervention along with measures of enjoyment and job strain.

Results

A 3×2 mixed analysis of variance identified that, in study 1, the digital game condition increased energetic arousal (indicative of improved recovery) whereas the other 2 conditions decreased energetic arousal (F2,42=3.76; P=.03). However, there were no differences between the conditions in recovery experience (F2,42=.01; P=.99). In study 2, multilevel model comparisons identified that neither the intervention nor day of the week had a significant main effect on how energized participants felt. However, for those in the digital game condition, daily recovery experience increased during the course of the study, whereas for those in the mindfulness condition, it decreased (F1,18=9.97; P=.01). Follow-up interviews with participants identified 3 core themes: detachment and restoration, fluctuations and differences, and routine and scheduling.

Conclusions

This study suggests that digital games may be effective in promoting post work recovery in laboratory contexts (study 1) and in the real world, although the effect in this case may be cumulative rather than instant (study 2).
Seasonality Patterns of Internet Searches on Mental Health: Exploratory Infodemiology Study
Authors: Soreni Noam , Cameron Duncan H , Streiner David L , Rowa Karen , McCabe Randi E
Published: February 2019

Background

The study of seasonal patterns of public interest in psychiatric disorders has important theoretical and practical implications for service planning and delivery. The recent explosion of internet searches suggests that mining search databases yields unique information on public interest in mental health disorders, which is a significantly more affordable approach than population health studies.

Objective

This study aimed to investigate seasonal patterns of internet mental health queries in Ontario, Canada.

Methods

Weekly data on health queries in Ontario from Google Trends were downloaded for a 5-year period (2012-2017) for the terms “schizophrenia,” “autism,” “bipolar,” “depression,” “anxiety,” “OCD” (obsessive-compulsive disorder), and “suicide.” Control terms were overall search results for the terms “health” and “how.” Time-series analyses using a continuous wavelet transform were performed to isolate seasonal components in the search volume for each term.

Results

All mental health queries showed significant seasonal patterns with peak periodicity occurring over the winter months and troughs occurring during summer, except for “suicide.” The comparison term “health” also exhibited seasonal periodicity, while the term “how” did not, indicating that general information seeking may not follow a seasonal trend in the way that mental health information seeking does.

Conclusions

Seasonal patterns of internet search volume in a wide range of mental health terms were observed, with the exception of “suicide.” Our study demonstrates that monitoring internet search trends is an affordable, instantaneous, and naturalistic method to sample public interest in large populations and inform health policy planners.
The Influence of Individual and Environmental Factors on Small Business Performance of Briquettes In Bangunharjo Village, Bantul Regency
Authors: Syikhristani Syikhristani , Jamhari Jamhari , Darwanto Dwidjono Hadi
Published: February 2019

This study aims to: (1) acknowledge the application level of the individual factor and work environment to the employee of the coconut shell briquette small business in Bangunharjo Village, Bantul Regency, (2) acknowledge the performance level of the employee of the coconut shell briquette small business in Bangunharjo Village, Bantul Regency, (3) acknowledge the effectiveness of the individual factor and work environment toward the employee’s performance of the coconut shell briquette small business in Bangunharjo Village, Bantul Regency. The location and the sample of the research are determined in purpose based on the certain consideration and criteria through a case study. The method used in this study comprises of two independent variables and one dependent variable. The number of respondent taken are 31 people consisting of business owner and employee. The questionnaire technique being used is questionnaire with likert scale measurement 1-5 from attitude strongly disagree to strongly agree, assisted Statistical Product and Service Solutions (SPSS) program version 24 in order to obtain the descriptive data analysis, the correlation of person product moment, and double linear regression with 5% significancy range. The result of the analysis reveals: (1) the level of application of individual factors and the work environment for employees are in a good category; (2) the measurement through the employee's performance is good; (3) Individual factor and work environment both have a significant positive effect on employee's performance, this is proven by the discovery of adjusted R squared value that is 0.727 on the determination coefficient.
Penilaiaan Mutu Hasil Beberapa Galur Harapan Padi Gogo Aromatik
Authors: Taryono Taryono
Published: February 2019

Penilaian bertujuan untuk....
Cost Effectiveness Analysis of Crystalloid and Crystaloid-Colloid Combination on Dengue Fever without Shok in Bhakti Asih General Hospital Tangerang
Authors: Suratni Suratni , Anggriani Yusi , Banun Agusdini
Published: February 2019

Dengue fever is an infectious disease caused by virus transmitted through Aedes aegypty. The high incidence dengue fever can lead to increased healthcare costs. This study was conducted to analyze the effectiveness and direct cost of medical patients dengue fever without shock use fluid therapy by comparing crystalloid and crystalloid colloid combination. The subjects were 171 patients divided into two groups: 106 patients with crystalloid and 65 patients with crystalloid colloid combination. Assessed of effectiveness treatment and the mean medical costs. The results showed reviewed from hematocrit value no difference (p>0.05) in both study groups. The mean total cost of treatment for crystalloid Rp 4.005.223, the crystalloid colloid combination Rp 5.525.407. The highest cost of drug costs was 31.75% of the total cost crystalloid, 40.9% of the total cost crystalloid colloid combination. There was a significant difference between mean cost and two study groups (p0.05) with effectiveness treatment. Conclusion crystalloid have the same effectiveness as crystalloid colloid combination fluids at lower costs.
Drug Interaction Potency on Type 2 Diabetes Mellitus Patient in Hospital X in South Tangerang
Authors: Saibi Yardi , Hasan Delina , Shaqila Verona
Published: February 2019

Drug interaction is an interaction among a drug with other ingredients that prevents the drug from giving certain or expected effect. Such interaction might happen between a drug and other drugs, drugs with food, as well as drugs and disease. Potential drug interaction in patients with type 2 diabetes mellitus in some hospitals had been reported by several previous publications. This study aimed to identify the potential of drug interactions in patients with type 2 diabetes mellitus at Hospital X, South Tangerang. This paper is a descriptive research with retrospective retrieval data. Data were obtained in the form of patient medical records from July 2014 to June 2015. Data analysis was done by descriptive statistic analysis using SPSS version 16. The results showed that there were 90 medical records that fulfilled the inclusion criteria. Of these, 57.7% was found to be potential drug interaction. There are 55 drug interactions that potentially cause hypoglycemia, and there are 21 times that potentially cause hyperglycemia. The severity of interaction in moderate category was 89.39% (total of 66), and the rest was in minor category. Major categories were not found. The potential for drug interactions in type 2 diabetes mellitus patients is quite common and these findings complement the findings of previous published studies. Physicians and pharmacists as health workers who are directly related to the treatment of patients need to increase awareness of the potency of interactions of these drugs.
Microemulsion Formulation of Combination of Virgin Coconut Oil and Rice Bran Oil for Hair Growth
Authors: Suhery Wira Noviana , Febrina Mira , Permatasari Ivone
Published: February 2019

Research on micro emulsion formulation of combination of virgin coconut oil (VCO) and rice bran oil (RBO) as a hair growth promoter has been done. The purpose of this study was to formulate and produce the best formula that is physically stable and optimally promoting the hair growth by varying the content of VCO and RBO in the form of micro emulsions. These dosage formulations were prepared in three formulas using 45% tween 80 as surfactants and 20% glycerin as co surfactant i.e.: F,I containing a combination of VCO and RBO 1:1; FII (1:2) and FIII (2:1). Physical evaluation of the preparation was carried out for 8 weeks of storage which included organoleptic examination, pH, homogeneity, density, globule particle size, phase freeze thaw, and rabbit hair growth activity test for 18 days. Based on the results of the evaluation, it was found that the FI, FII and FIII micro emulsion formulations were physically stable for 8 weeks of storage with a pH ranging from 6.7 to 7.0, density of 1.085-1.088 g/mL, average globul particle size of FI (34.6 nm ), FII (54 nm) and FIII (68.8 nm). The best formulas is FIII for hair growth length of 1.26 cm for 18 days.
The usage of Jati Leaves Extract (Tectona grandis L.f) As color of lipstick
Authors: Setyawaty Rety , Pratama Meldina R.
Published: February 2019

Lipstick is one of the most used cosmetics by women. According to Tranggano and Latifah (2007), lipstick is a cosmetic applied to the lips, to protect the lips in cold and dry air so that the lips are not easy to dry and crack. Lipstick is used by women for a long time so that lipstick should be safe and do not cause irritation. Chemicals substances in the manufacture of lipstick can accidentally be consumed and long-term use so that its accumulation in the body would be harmful to health. Synthetic lipstick color is one part of the dangerous lipstick making material. Synthetic substances can be replaced with natural dyes. The use of natural dye limits on cosmetics is 5-15% (Mercado, 1991). One example of natural dyes that can be used is the dye from the Jati leaves (Tectona grandis L.f). This study aim is to prove that Jati leaves (Tectona grandis L.f) can be used as a natural dye in the material of lipstick. The method used in this research is the method of extraction maceration with jati leaf samples of 300 grams and ethanol of 96%. Component of lipstick formula which are cera alba, lanolin, vaseline, cetyl alcohol, paraffin solid, oleum ricini, oleum rosae, propylene glycol, butyl hydroxytoluene, methyl paraben, and the addition Jati leaf extract under the concentration of 0%, 18% , and 22%. The material of lipstick is easy to apply, stable, brown color, homogeneous, melting point of 600C, range pH between 3 at 4 and lipstick have a breaking point of 500 grams. Jati leaf extract (Tectona grandis L.f) can be used as a dye or color of lipstick.
Determination of γ-oryzanol, Phenolic total content, and (2,2-difenil-1-picrylhydrazyl) Radical Scavenging Activity in Different Varieties of Rice (Oryza sativa) in Yogyakarta, Indonesia
Authors: Setyowati Erna Prawita , Gani Andayana Puspitasari
Published: February 2019

In Indonesia, beras (Oryza sativa) has become the main ingredient in natural beauty products such as masks, scrubs, and cold powder. γ-oryzanol and phenolic compounds are the major components in beras that have many benefits, one of which as antioxidants. This study aims to determine the content of γ-oryzanol and total phenolic compounds in different beras cultivars in the area of Yogyakarta. The leveling was done by a TLC-densitometry method and Folin Ciocalteu. The results showed that the largest γ-oryzanol content found in red beras was 0.0843% by weight of the sample. The highest total phenolic content was found in red beras as much as 1.92% by weight of the sample. The antioxidants activity IC50 Red Beras is 0.591.
Acute Tocixity of Sterculia quadrifida R.Br Bark Ethanol Extract on Sprague-Dawley Rats
Authors: Siswadi Siswadi , Saragih Grace S.
Published: February 2019

Faloak (Sterculia quadrifida R.Br) is a medicinal plant used by people in the province of East Nusa Tenggara to treat hepatitis. This study aims to determine the acute toxicity of faloak (Sterculia quadrifida R. Br) bark ethanol extract in Sprague-Dawley (SD) male white rats. The method used is experimental using post-test only control group design. In this study the parameters used are body weight, clinical symptoms, clinical biochemistry (ALT & AST), histopathology of liver organ and mortality in rats. Twenty male Sprague-Dawley rats were randomly assigned to 5 groups, group 1 as control, group 2 was administered orally faloak bark ethanol extract at dose of 40 mg / kg body weight, group 3 at dose of 200 mg / kg body weight, group 4 at dose of 1000 mg / kg body weight and group 5 at dose of 5000 mg / kg body weight. Results of observation for 24 hours there are no dead rats, so the value of LD50 extract ethanol faloak is > 5,000 mg / kg body weight. Observations were conducted for 14 days to observed delayed occurrence of toxic effects. Oral administration of the faloak bark ethanol extract reduced the level of AST and ALT. The histopathology observation of rats liver cells showed liver cell necrosis at treatment doses of 200 - 5,000 mg / kg body weight.
ANALISIS PENGARUH INVESTASI, PDRB, JUMLAH PENDUDUK, PENERIMAAN PEMBANGUNAN, DAN INFLASI TERHADAP PENDAPATAN ASLI DAERAH (PAD) DI KABUPATEN LOMBOK BARAT
Authors: Batik Karlina
Published: February 2019

Mark sense application autonomousing to expected region gets to give facility to region to even out its own housewifery, also give room opportunity for region to dig up and mendayagunakan is proprietary potency optimal ala. PAD as one of accepting region reflects to increase region independence. The greater PAD therefore points out that region progressively is able to   dig up and utilizes source those are at its region. To the effect that wants to be reached   in this research is menganalisis affecting investment, PDRB, population, Development acceptance, and inflation to PAD. Observed data in this research is time series's data with runtut time 1980 2007. Estimation model that is utilized is bifilar regression that ditranspormasikan goes to to form logarithm.
PENGARUH MODAL DAN TENAGA KERJA USAHA PENGRAJIN BATIK TULIS KLASIK TERHADAP TINGKAT PRODUKSI (Studi Pada Industri Kecil Menengah “ IKM “ Batik Tulis Klasik di Desa Margorejo, Kecamatan Kerek, Kabupaten Tuban)
Authors: Hidayatullah Muhammad Nur
Published: February 2019

The objective of this study was to investigate the effects of capital and labor in both small and medium industries of classic batik entrepreneurs in Margorejo Village, Kerek District, Tuban. The result of multiple linear regression analysis shows that: Y = -6.286474 + 0.695922 1.260502 X1 + X2. Regression coefficient of 0921 states the influence of the amount of labor (X1) and capital (X2) on the production of batik per month (Y), meaning amount of labor (X1) and capital (X2). While the rest of 7.80% is determinaned by factors beyond the studied variables
ECONOMIC STRUCTURE ANALYSIS, LEADING SECTORS AND	REGIONAL DEVELOPMENT IN MALANG YEAR 2008-2012.
Authors: Santoso Seno Aji
Published: February 2019

The purpose of this study was to determine the structure of the economy, the dominant sector and regional development strategies in Malang Year 2008-2012.From the analysis it can be concluded that by using a tool known for Economic Structural Analysis of 9 existing economic sector in Gross Domestic Product during the years 2008 to 2012 the sector that contributes most to the Gross Domestic Product (GDP) at constant prices Malang is the sector tertiary contributing 64.82 %. From the analysis of the leading sectors, Malang has a leading sectors are trade, hotels, and restaurants with LQ value of 1.29 and a differential value shift by shift proportional 195,272.27 and 135,101.68. From the analysis of gravity, Malang has the greatest interaction with the Malang region. For the development of Malang area is quite well characterized by an increase in Gross Domestic Product (GDP) from year to year but still needs to be developed further other economic sectors that still have the potential to compete with other regions in East Java.
Pengaruh Infrastruktur dan Keterkaitan Spasial Terhadap Konvergensi Beta di Indonesia
Authors: Fahmi Anisa
Published: February 2019

Motivated inter-regional disparities condition that occurs persistently, this thesis examines the Indonesian economy in the long run, whether it will tend to converge or diverge. This convergence is based on the Solow Neoclassical growth theory which assumes the existence of diminishing returns to capital so that when the developed countries reach steady state conditions, developing countries will continuous growth up to ‘catch-up‘ with developed countries. This thesis also focuses on the influence of spatial dependency and infrastructure since regional economics perspective, each region can not be treated as a stand-alone unit. Economical and political situation of a region will influence policy in that region which will also have an impact to the neighboring regions. The estimation results of  spatial cross-regressive model using fixed effect method consistently confirmed that the Indonesian economy in the long term will likely converge with a speed of 8.08 percent per year. Other finding is, road infrastructure has a positive effect on economic growth and investment  and road infrastructure are spatially showed a positive effect on economic growth. In other words, the investment and the infrastructure of a region not only affect the economic growth of that region but also to the economy of the contiguous region.
STRATEGI PERCEPATAN PENCAPAIAN TARGET MILLENIUM DEVELOPMET GOALS (MDGs) DI KOTA MALANG
Authors: Nuraini Ida , Susilowati Dwi
Published: February 2019

The purpose of this study is a map of the readiness of Malang in achieving the MDGs by 2015 and the right strategy based on SWOT analysis to accelerate the achievement of the target MDGs.Dari can be concluded that the MDG targets by 8 item in Malang in 2015 still can not be reached. The number of poor people was 43,400 people, the open unemployment of 5.19% (22.185%). The adult literacy rate of 4.57% or 34 717 persons. Percentage of the population 10 years and over who do not have a diploma of 21.21%, finished primary school / MI amounted to 23.77% and 18.17% of junior high school graduation. In the field of gender equality, the contribution of women in politics is still very low. In the health field there are still 245 the number of infant deaths and 10 cases of maternal mortality. People with HIV and March 2013 reached 2,134 and AIDS as many as 341 people with high risk factors through needle drugs and high risk in men (65%) at the age of 25-49 years. The field of environmental sustainability in some respects much decreased as the quality of drinking water, air quality and temperature.
ANALISIS PENDAPATAN PEDAGANG MIKRO MAKANAN DAN MINUMAN DI SEKITAR MALL DINOYO CITY
Authors: Nisantoro Wahyu Dwi
Published: February 2019

This study aimed to analyze the effect of variable capital , trading hours and locations micro traders to trade on the income of food and drinks around the Mall Dinoyo City Malang. In this study using primary data through direct interviews on 60 respondents micro traders of food and drinks around the Mall Dinoyo City with a list of questions that had been prepared . To achieve the goal, in this study using regression analysis ( OLS ). The results of this study indicate that the variable capital and trade locations positive and significant impact on the micro traders of food and drinks around the Mall Dinoyo . While variable trading hours do not significantly affect the income micro traders of food and drinks around the Mall Dinoyo City .
ANALISIS PERDAGANGAN INDONESIA PASCA PEMBERLAKUAN ACFTA (STUDI KOMPARATIF INDONESIA-CHINA)
Authors: Muslihati .
Published: February 2019

Every international economy linking countries through two channels: trade in goods and services (real sector) and financial sector. Trade relations means that some products from a country that exported abroad, while some goods that are consumed or invested in the country are imported from abroad. The strong role of international trade is partly reflected in the goods market will be able to help us to know how big contribution to the real sector is affected by exchange rate and net exports to increase income or national output. All economies, regardless of size, depends on other economies and are affected by events beyond its limits.The existence of an agreement between Indonesia and China as stipulated in the agreement more or less ACFTA will influence the increase or decrease in Indonesia's trade balance are reflected in an increase or decrease in GNP. Indonesia's ability to see its comparative advantage will be able to increase the competitiveness of Indonesian products in the international market.
ANALISIS PENGARUH SUKU BUNGA KREDIT DAN KRISIS EKONOMI TERHADAP PENANAMAN MODAL DALAM NEGERI DI INDONESIA TAHUN 1990-2010
Authors: Alfarisi Salman
Published: February 2019

This study aims to determine the development of  domestic direct investment (DDI) with lending rates level and to determine the effect of lending rates and economic crisis on domestic direct investment (DDI) in Indonesia in 1990-2010. Based on the result of regression analysis found that the coefficient value of determination (R2) is 0.499. It means the ability of the independent variables consist of lending rates level and economic crisis which is able to explain 49 % of the dependent variable that is domestic direct investment (DDI). From the t test results obtained the level of lending rates have a significant influence on domestic direct investment (DDI) this is proved by t count > t table is amounted to -4.235 > 2.101. On the other hand, the economic crisis has the value t count is 2.432, therefore, the economic crisis also significantly influence the domestic direct investment (DDI). Obtained from the F test that both of lending rates level and economic crisis significantly influence on domestic direct investment (DDI). This is proved by the value of F count (8.972) > F table (3.55).
Thermodynamics as a Consequence of Information Conservation
Authors: Bera Manabendra Nath , Riera Arnau , Lewenstein Maciej , Khanian Zahra Baghali , Winter Andreas
Published: February 2019

Thermodynamics and information have intricate interrelations. Often thermodynamics is considered to be the logical premise to justify that information is physical - through Landauer's principle -, thereby also linking information and thermodynamics. This approach towards information has been instrumental to understand thermodynamics of logical and physical processes, both in the classical and quantum domain. In the present work, we formulate thermodynamics as an exclusive consequence of information conservation. The framework can be applied to the most general situations, beyond the traditional assumptions in thermodynamics: we allow systems and thermal baths to be quantum, of arbitrary sizes and even possessing inter-system correlations.Here, systems and baths are not treated differently, rather both are considered on an equal footing. This leads us to introduce a ''temperature''-independent formulation of thermodynamics. We rely on the fact that, for a fixed amount of information, measured by the von Neumann entropy, any system can be transformed to a state with the same entropy that possesses minimal energy. This state, known as a completely passive state, acquires Boltzmann-Gibbs canonical form with an intrinsic temperature. We introduce the notions of bound and free energy and use them to quantify heat and work, respectively. Guided by the principle of information conservation, we develop universal notions of equilibrium, heat and work, Landauer's principle and universal fundamental laws of thermodynamics. We demonstrate that the maximum efficiency of a quantum engine with a finite bath is in general lower than that of an ideal Carnot engine. We introduce a resource theoretic framework for our intrinsic temperature based thermodynamics, within which we address the problem of work extraction and state transformations. Finally, the framework is extended to multiple conserved quantities.