bluuebunny/crossref_metadata_2025 huggingface dataset:
Exploring New Vista of Intelligent Recommendation Framework for Tourism Industries: An Itinerary through Big Data Paradigm
Authors: Sarkar Manash , Roy Arup , Agrebi Maroi , AlQaheri Hameed
Published: January 2022

Big Data is changing how organizations conduct operations. Data are assembled from multiple points of view through online quests, investigation of purchaser purchasing conduct, and then some, and industries utilize it to improve their net revenue and give an overall better experience to clients. Each of these organizations must figure out how to improve the general client experience and meet every client’s novel necessities, and big data helps with this cycle. Through the utilization and reviews of Big Data, travel industry organizations can study the inclinations of more modest portions of their intended interest group or even about people in some cases. In this paper, a Crow Search Optimization-based Hybrid Recommendation Model is proposed to get accurate suggestions based on clients’ preferences. The hybrid recommendation is performed by combining collaborative filtering and content-based filtering. As a result, the advantages of collaborative filtering and content-based filtering are utilized. Moreover, the intelligent behavior of Crows’ assists the proper selection of neighbors, rating prediction, and in-depth analysis of the contents. Accordingly, an optimized recommendation is always provided to the target users. Finally, performance of the proposed model is tested using the TripAdvisor dataset. The experimental results reveal that the model provides 58%, 58.5%, 27%, 24.5%, and 25.5% better Mean Absolute Error, Root Mean Square Error, Precision, Recall, and F-Measure, respectively, compared to similar algorithms.
Acknowledgment to Reviewers of Infrastructures in 2021
Authors:   Infrastructures Editorial Office
Published: January 2022

Rigorous peer-reviews are the basis of high-quality academic publishing [...]
No Impact of Biocontrol Agent’s Predation Cues on Development Time or Size of Surviving Aedes albopictus under Optimal Nutritional Availability
Authors: Russell Marie C. , Cator Lauren J.
Published: February 2022

Cyclopoid copepods have been applied successfully to limit populations of highly invasive Aedes albopictus mosquitoes that can transmit diseases of public health importance. However, there is concern that changes in certain mosquito traits, induced by exposure to copepod predation, might increase the risk of disease transmission. In this study, third instar Ae. albopictus larvae (focal individuals) were exposed to Megacyclops viridis predator cues associated with both the consumption of newly hatched mosquito larvae and attacks on focal individuals. The number of newly hatched larvae surrounding each focal larva was held constant to control for density effects on size, and the focal individual’s day of pupation and wing length were recorded for each replicate. Exposing late instar Ae. albopictus to predation decreased their chances of surviving to adulthood, and three focal larvae that died in the predator treatment showed signs of melanisation, indicative of wounding. Among surviving focal Ae. albopictus, no significant difference in either pupation day or wing length was observed due to copepod predation. The absence of significant sublethal impacts from M. viridis copepod predation on surviving later stage larvae in this analysis supports the use of M. viridis as a biocontrol agent against Ae. albopictus.
Beyond the N-Limit of the Least Squares Resolution and the Lucky Model
Authors: Landi Gregorio , Landi Giovanni E.
Published: January 2022

A very simple Gaussian model is used to illustrate an interesting fitting result: a linear growth of the resolution with the number N of detecting layers. This rule is well beyond the well-known rule proportional to N for the resolution of the usual fits. The effect is obtained with the appropriate form of the variance for each hit (observation). The model reconstructs straight tracks with N parallel detecting layers, the track direction is the selected parameter to test the resolution. The results of the Gaussian model are compared with realistic simulations of silicon micro-strip detectors. These realistic simulations suggest an easy method to select the essential weights for the fit: the lucky model. Preliminary results of the lucky model show an excellent reproduction of the linear growth of the resolution, very similar to that given by realistic simulations. The maximum likelihood evaluations complete this exploration of the growth in resolution.
The Latest Advances in Wireless Communication in Aviation, Wind Turbines and Bridges
Authors: Śliwa Romana Ewa , Dymora Paweł , Mazurek Mirosław , Kowal Bartosz , Jurek Michał , Kordos Damian , Rogalski Tomasz , Flaszynski Pawel , Doerffer Piotr , Doerffer Krzysztof , Grigg Stephen , Unnthorsson Runar
Published: January 2022

Present-day technologies used in SHM (Structural Health Monitoring) systems in many implementations are based on wireless sensor networks (WSN). In the context of the continuous development of these systems, the costs of the elements that form the monitoring system are decreasing. In this situation, the challenge is to select the optimal number of sensors and the network architecture, depending on the wireless system’s other parameters and requirements. It is a challenging task for WSN to provide scalability to cover a large area, fault tolerance, transmission reliability, and energy efficiency when no events are detected. In this article, fundamental issues concerning wireless communication in structural health monitoring systems (SHM) in the context of non-destructive testing sensors (NDT) were presented. Wireless technology developments in several crucial areas were also presented, and these include engineering facilities such as aviation and wind turbine systems as well as bridges and associated engineering facilities.
Introducing the Living Lab Approach in the Coastal Area of Constanta (Romania) by Using Design Thinking
Authors: Anton Catalin , Micu Angela Eliza , Rusu Eugen
Published: January 2022

Living Labs are an innovative concept that combines research, governance, and citizens, using technology and knowledge. Using design thinking techniques as a method of approach, this innovative idea builds a bridge between decision makers and stakeholders, promoting a shared vision of growth and innovation at the community level. The coastal zone is an extremely dynamic area in terms of human and natural activities. This is a particularly sensitive area to climate change, necessitating ongoing adaptation and mitigating action. This paper aims to introduce the application of the Living lab concept in the management of the coastal area of Constanta (Romania). The concept of the Living Lab means involving citizens along with public bodies and research structures. This new coastal management model will use the design thinking approach and will consider the pressures that exist between the activities that occur in the examined coastal zone. In the study, “Multi-Criteria Analysis of the Mass Tourism Management Model Related to the Impact on the Local Community in Constanța (Romania)”, published in MDPI Inventions on 28 June 2021, a coastal management model was built that took into consideration only the data given by the government. In this paper, the authors aim to expand their research by including data from independent sources, using the concept of a Living Lab.
Targeted Therapy, Chemotherapy, Immunotherapy and Novel Treatment Options for Different Subtypes of Salivary Gland Cancer
Authors: Mueller Sarina K. , Haderlein Marlen , Lettmaier Sebastian , Agaimy Abbas , Haller Florian , Hecht Markus , Fietkau Rainer , Iro Heinrich , Mantsopoulos Konstantinos
Published: January 2022

Surgical resection remains the first line treatment for salivary gland cancer (SGC). In the case of locally advanced disease, surgery is followed by adjuvant radiotherapy. Surgical resection should be favored in resectable locoregional recurrent disease as well, and even the complete resection of all distant oligometastases has clinical benefit for the patients. For inoperable and disseminated metastatic disease, a multitude of systemic therapies including chemotherapy, targeted therapy, and immunotherapy are available. In this review, the current therapeutic options for inoperable recurrent or metastatic SGCs are summarized. Systemic treatment can achieve prolonged progression-free and overall survival, while the overall prognosis remains poor. Current clinical trials include only a limited number of patients and mostly combine different histologic subtypes. Additionally, no randomized controlled trial comparing different therapeutic options has been performed. In the future, further studies with a larger patient cohort and ideally only one histologic subtype are needed in order to improve the outcome for SGC patients. However, this may be difficult to accomplish due to the rarity and diversity of the disease. Additionally, molecular analyses need to be performed routinely in order to individualize treatment and to go one step further towards precision medicine.
Interventional Radiology’s Osteoid Osteoma Management: Percutaneous Thermal Ablation
Authors: Bianchi Giampaolo , Zugaro Luigi , Palumbo Pierpaolo , Candelari Roberto , Paci Enrico , Floridi Chiara , Giovagnoni Andrea
Published: January 2022

Osteoid osteoma (OO) is one of the most common benign bone tumors with specific clinical and radiological characteristics. Analgesic therapy and surgical treatment have been considered the only therapy for a long time. Recently, safe and effective new therapeutic options have been introduced, among which percutaneous thermal ablation techniques. This review aims to describe the recent updates in the field of percutaneous thermal ablation techniques in the treatment of OO, assessing the outcomes in terms of efficacy, complications, and recurrence rate.
Procurement of Uterus in a Deceased Donor Multi-Organ Donation National Program in France: A Scarce Resource for Uterus Transplantation?
Authors: Dion Ludivine , Santin Gaëlle , Nyangoh Timoh Krystel , Boudjema Karim , Jacquot Thierry Louise , Gauthier Tristan , Carbonnel Marie , Ayoubi Jean Marc , Kerbaul François , Lavoue Vincent
Published: January 2022

Uterus transplantation is a new possibility for women suffering from absolute uterine infertility to become pregnant and have children. In the case of a deceased donor, a list of exclusion criteria is defined to ensure the high quality of the uterus graft. This study evaluates the number of potentially available uterus grafts based on the pre-defined exclusion criteria in a national deceased donor multi-organ donation program in France. We analyzed the data reported in the CRISTAL database regarding all women aged 18 to 60 on whom organ procurement was performed between 2014 and 2019. Potential deceased women donors were classified into three categories: very ideal donor, ideal donor, and expanded criteria donor. Between 2014 and 2019, 4544 women underwent organ procurement. Using the very ideal donor, ideal donor, and expanded criteria donor classification, we found that, respectively, only 124, 264, and 936 donors were potentially eligible for UTx. This represents 2.8 per million people (PMP) very ideal donors, 3.8 PMP ideal donors, 8.6 PMP expanded criteria donors (ECDs). The restricted number of grafts requires a complementary strategy of living and deceased donors to meet the demand of all women with AUI.
Alexithymia in Adolescents with Acne: Association with Quality of Life Impairment and Stigmatization
Authors: Szepietowska Marta , Dąbrowska Alicja , Nowak Bernadetta , Skinderowicz Katarzyna , Wilczyński Bartosz , Krajewski Piotr K. , Jankowska-Konsur Alina
Published: January 2022

Alexithymia seems to be more common among patients with skin diseases. However, studies on acne patients are very limited. We conducted this study to evaluate alexithymia in adolescents with acne. In our cross-sectional study, 730 high school students (mean age: 17.05 ± 1.18 years) were recruited. The Toronto Alexithymia Scale (TAS-20) was used to measure alexithymia, the Dermatology Life Quality Index (DLQI) was employed to study quality of life (QoL), and the 6-item Stigmatization Scale (6ISS) was used to evaluate the level of stigmatization in acne subjects. Alexithymia was found in 31% of adolescents, with similar prevalence among those with and without acne (31.3% and 30.1%, respectively). The mean scoring on the TAS-20 in patients with acne (53.1 ± 12.8 points) was not significantly different from that of the non-acne group (53.5 ± 11.9 points). However, significant correlations between TAS-20 scores and QoL assessments (r = 0.332, p < 0.001) as well as stigmatization level (r = 0.284, p < 0.001) were found. These correlations were also significant for the domains of alexithymia described as difficulty in identifying feelings (DIF) and difficulty in describing feelings (DDF), but not for externally oriented thinking (EOT). The findings clearly showed that acne does not predispose to alexithymia; however, alexithymia in acne subjects is related to impaired QoL and stigmatization.
Combination of CLEC4M rs868875 G-Carriership and ABO O Genotypes May Predict Faster Decay of FVIII Infused in Hemophilia A Patients
Authors: Lunghi Barbara , Morfini Massimo , Martinelli Nicola , Linari Silvia , Castaman Giancarlo , Bernardi Francesco
Published: January 2022

The C-type lectin CLEC4M binds and internalizes factor VIII (FVIII). Common CLEC4M variants have been associated with FVIII pharmacokinetic (PK) profiles in hemophilia A (HA) patients. The two-compartment PK analysis of plasma-derived (pd-) and full length recombinant FVIII concentrates was conducted in twenty-six patients (FVIII:C ≤ 2 IU/dL). F8, ABO blood-groups, and the CLEC4M rs868875A/G polymorphism were genotyped. CLEC4M genotype groups differed for the elimination rate constant K 1-0 (p < 0.001), half-life (K 1-0 HL), and the Beta rate constant. Patients treated with pd-FVIII also differed in the Alpha phase. In linear regression models, the contribution of the CLEC4M genotypes to FVIII PK parameters remained significant after correction for ABO, age, and VWF antigen levels at PK. Combined CLEC4M rs868875A/G and ABO genotypes displayed significant interaction (K 1-0, p = 0.014). Compared to other combined genotypes, the G-carriers/O genotypes showed half-reduced K 1-0 HL (p = 0.008), and faster FVIII clearance (mean 7.1 ± 2.2 mL/h/kg SE) than in the G-carriers/non-O (mean 2.4 ± 0.3 mL/h/kg SE), (p = 0.038). Comparison in HA patients recruited in several countries suggests that CLEC4M genotypes coherently influence infused FVIII half-life and clearance. Our analysis supports substantially faster FVIII decay associated with the rs868875 G-carrier/ABO O genotypes, which has potential implications for genetically tailored substitutive HA treatment.
Clinical Management of Thrombotic Antiphospholipid Syndrome
Authors: Tumian Nor Rafeah , Hunt Beverley J.
Published: January 2022

Thrombotic manifestations of antiphospholipid syndrome are often a therapeutic dilemma and challenge. Despite our increasing knowledge of this relatively new disease, many issues remain widely unknown and controversial. In this review, we summarise the latest literature and guidelines on the management of thrombotic antiphospholipid syndrome. These include the laboratory assays involved in antiphospholipid antibodies (aPL) testing, the use of direct oral anticoagulants in secondary prevention, management of recurrent thrombosis, individuals with isolated aPL, and catastrophic antiphospholipid syndrome. Treatment aims to prevent the potentially fatal and often disabling complications of APS with antithrombotic and cardiovascular risks prevention strategies. Some insights and updates on topical issues in APS are provided. We also include our current practice, which we believe is the pragmatic approach based on the currently available evidence.
Frozen Blastocyst Embryo Transfer: Comparison of Protocols and Factors Influencing Outcome
Authors: Eleftheriadou Aikaterini , Francis Abraham , Wilcox Mark , Jayaprakasan Kanna
Published: January 2022

Background: Various factors, including treatment protocols, can influence the outcomes of frozen embryo transfers (FETs). The study objectives were to compare different endometrial preparation protocols of FET cycles and to evaluate the factors, including the endometrial thickness (ET), that affect outcomes. Methods: This observational cohort study involved 5037 women undergoing FETs at eight tertiary clinics in the UK between January 2016 and March 2019. The endometrial preparation protocols used were natural cycle (NC-FETs), artificial hormone support cycle with oestradiol valerate but without pituitary downregulation (AC-FETs) and artificial hormone support cycle with agonist downregulation (ACDR-FETs). Results: The mean (±SD) ages across NC-FET, AC-FET and ACDR-FET groups were 36.5 (±4.2), 35.9 (±5.0) and 36.4(±4.9) years, respectively. LBRs were comparable (40.7%, 175/430; 36.8%, 986/2658; and 36.7%, 716/1949, respectively) across the three groups. Clinical pregnancy, implantation, multiple pregnancies, miscarriage and ectopic pregnancy rates were also similar. In the regression analysis of variables including age, duration of infertility, number of embryos transferred, protocol type and endometrial thickness, age was the only significant predictor of LBRs, although its predictive ability was poor (AUC: 0.55). With the overall LBR of the study population being 37.1%, the post-test probability of a live birth at an ET of <5 mm was 0%, and at 5–5.9, 6–6.9, 7–7.9 and 8–8.9 mm, the probabilities were 16.7%, 33.8%, 36.7% and 37.7%, respectively. The LBR remained above 35% up to the 14–14.9 mm range and then declined gradually to 23% for the 17–25 mm range. Conclusions: The FET outcomes were similar for the three protocols used for endometrial preparation. The protocol type and endometrial thickness were not predictive of FET outcomes; age was the only predictive variable, despite its low predictive ability.
Clinical Manifestations of Leukocytoclastic Vasculitis, Treatment, and Outcome in Patients with Ulcerative Colitis: A Systematic Review of the Literature
Authors: Pantic Ivana , Jevtic Djordje , Nordstrom Charles W. , Madrid Cristian , Milovanovic Tamara , Dumic Igor
Published: January 2022

Leukocytoclastic vasculitis (LCV) is a rare extraintestinal manifestation (EIM) of ulcerative colitis (UC). Observations about its association with UC stem from case reports and small case series. Due to its rarity, more rigorous cross-sectional studies are scarce and difficult to conduct. The aim of this systematic review was to synthetize the knowledge on this association by reviewing published literature in the form of both case reports and case series; and report the findings according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. In contrast to LCV in Chron disease (CD), which occurs secondary to biologic therapies used for its treatment, LCV in UC is a true reactive skin manifestation. Both genders are equally affected. Palpable purpura (41%) and erythematous plaques (27%) are the most common clinical manifestations. In 41% of patients, the rash is painful, and the lower extremities are most commonly involved (73%). Systemic symptoms such as fever, arthralgias, fatigue, and malaise are seen in 60% of patients. Unlike previous reports, we found that LCV more commonly occurs after the UC diagnosis (59%), and 68% of patients have active intestinal disease at the time of LCV diagnosis. Antineutrophil cytoplasmic antibody (ANCA) is positive in 41% of patients, and 36% of patients have other EIMs present concomitantly with LCV. The majority of patients were treated with corticosteroids (77%), and two (10%) required colectomy to control UC and LCV symptoms. Aside from one patient who died from unrelated causes, all others survived with their rash typically resolving without scarring (82%).
Acute Bacterial Infections and Longitudinal Risk of Readmissions and Mortality in Patients Hospitalized with Heart Failure
Authors: Ng Tien M. H. , Oh Esther E. , Bae-Shaaw Yuna H. , Minejima Emi , Joyce Geoffrey
Published: January 2022

Aims: Infections are associated with worse short-term outcomes in patients with heart failure (HF). However, acute infections may have lasting pathophysiologic effects that adversely influence HF outcomes after discharge. Our objective was to describe the impact of acute bacterial infections on longitudinal outcomes of patients hospitalized with a primary diagnosis of HF. Methods and Results: This paper is based on a retrospective cohort study of patients hospitalized with a primary diagnosis of HF with or without a secondary diagnosis of acute bacterial infection in Optum Clinformatics DataMart from 2010–2015. Primary outcomes were 30 and 180-day hospital readmissions and mortality, intensive care unit admission, length of hospital stay, and total hospital charge, compared between those with or without an acute infection. Cohorts were compared after inverse probability of treatment weighting. Multivariable logistic regression was used to examine relationship to outcomes. Of 121,783 patients hospitalized with a primary diagnosis of HF, 27,947 (23%) had a diagnosis of acute infection. After weighting, 30-day hospital readmissions [17.1% vs. 15.7%, OR 1.11 (1.07–1.15), p < 0.001] and 180-day hospital readmissions [39.6% vs. 38.7%, OR 1.04 (1.01–1.07), p = 0.006] were modestly greater in those with an acute infection versus those without. Thirty-day [5.5% vs. 4.3%, OR 1.29 (1.21–1.38), p < 0.001] and 180-day mortality [10.7% vs. 9.4%, OR 1.16 (1.11–1.22), p < 0.001], length of stay (7.1 ± 7.0 days vs. 5.7 ± 5.8 days, p < 0.001), and total hospital charges (USD 62,200 ± 770 vs. USD 51,100 ± 436, p < 0.001) were higher in patients with an infection. Conclusions: The development of an acute bacterial infection in patients hospitalized for HF was associated with an increase in morbidity and mortality after discharge.
Survival Trends in Adults with Out-of-Hospital Cardiac Arrests after Traffic Collisions in Japan: A Population-Based Study
Authors: Hosomi Sanae , Kitamura Tetsuhisa , Sobue Tomotaka , Zha Ling , Kiyohara Kosuke , Oda Jun
Published: January 2022

The 1-month survival rate from out-of-hospital cardiac arrest (OHCA) of cardiac origin has reportedly improved recently, at ≥5%. However, the characteristics of patients with OHCA after a traffic collision have not been adequately evaluated in Japan. We analyzed the All-Japan Utstein Registry data of 12,577 adult patients aged ≥ 20 years with OHCA due to traffic collisions who were resuscitated by emergency medical service personnel or bystanders and were then transported to medical institutions between 2013 and 2019. Multiple logistic regression analysis was used to assess factors potentially associated with the 1-month survival rate after OHCA. The 1-month survival rate was 1.4% (174/12,577). The proportion of 1-month survival of all OHCAs after a traffic collision origin did not increase significantly (from 1.6% [30/1919] in 2013 to 1.8% [25/1702] in 2019), and the adjusted odds ratio for 1-year increments was 1.04 (95% confidence interval, 0.96–1.12). In multivariate analysis, men who received ventricular fibrillation, pulseless electrical activity, intravenous fluid replacement, or early emergency medical service response and had a traffic collision during daytime had significantly favorable 1-month outcomes. In Japan, the 1-month survival after OHCA of a traffic collision origin was lower than that of a cardiac origin and remains stable.
Non-Invasive Myocardial Work in Patients with Severe Aortic Stenosis
Authors: De Rosa Salvatore , Sabatino Jolanda , Strangio Antonio , Leo Isabella , Romano Letizia Rosa , Spaccarotella Carmen Anna , Mongiardo Annalisa , Polimeni Alberto , Sorrentino Sabato , Indolfi Ciro
Published: January 2022

Changes in cardiac mechanics after correction of severe Aortic Stenosis (AS) are under-investigated. Myocardial Work (MW) is emerging as a useful non-invasive correlate of invasively measured myocardial performance and oxygen consumption. The aim of this study was to assess the usefulness of MW in the clinical management of patients with AS undergoing transcatheter aortic valve implantation (TAVI). Consecutive patients referred for TAVI were included in this observational study. Echocardiograms were performed before and after TAVI to measure Global Work Index (GWI), Global Constructive Work (GCW), Global Wasted Work (GWW), and Global Work Efficiency (GWE). Mean transvalvular gradient was significantly improved (p < 0.05), without significant changes in left ventricular ejection fraction, nor in global longitudinal strain (GLS). GWI (p < 0.001) and GCW (p < 0.001), but not GWW (p = 0.241) nor GWE (p = 0.854) were significantly reduced after TAVI. Patients with a low flow low gradient (LF-LG) AS had lower left ventricular ejection fraction (LVEF) (p < 0.001), worse global longitudinal strain (GLS) (p < 0.001), and lower baseline GWI (p < 0.001), GCW (p < 0.001) and GWE (p = 0.003). The improvement in GWI and GCW observed after TAVI in the general study population were abolished among LF-LG patients. In conclusion, non-invasive MW might be useful to further classify patients with AS and to predict non responders.
Risk Factors and Surgical Management of Recurrent Herniation after Full-Endoscopic Lumbar Discectomy Using Interlaminar Approach
Authors: Ono Koichiro , Ohmori Kazuo , Yoneyama Reiko , Matsushige Osamu , Majima Tokifumi
Published: January 2022

Full-endoscopic lumbar discectomy (FED) is one of the least invasive procedures for lumbar disc herniation. Patients who receive FED for lumbar disc herniation may develop recurrent herniation at a frequency similar to conventional procedures. Reoperation and risk factors of recurrent lumbar disc herniation were investigated among 909 patients who received FED using an interlaminar approach (FED-IL). Sixty-five of the 909 patients received reoperation for recurrent herniation. Disc height, smoking, diabetes mellitus (DM), subligamentous extrusion (SE) type, and Modic change were identified as the risk factors for recurrence. Other indicators such as LL, Cobb angle, disc migration, age, sex, and body mass index (BMI) did not reach significance. Among 65 patients, reoperation was performed within 14 days following FED-IL (very early) in 7 patients, from 15 days to 3 months (early) in 14 patients, from 3 months to 1 year (midterm) in 17 patients, and after more than 1 year (late) in 27 patients. The very early group included a greater number of males, and the mean age was significantly lower in comparison to other groups. All patients in the very early group received FED-IL for reoperation. Reoperation within 2 weeks allows FED-IL to be performed without adhesion. Fusion surgery was performed on three cases in the early and midterm groups and on 10 cases in the late group, which increased over time as degenerative change and adhesion progressed. The procedure selected to treat recurrent herniation mostly depends on the surgeon’s preference. Revision FED-IL is the first choice for recurrent herniation in terms of minimizing surgical burden, whereas fusion surgery offers the advantage that discectomy can be performed through unscarred tissues. FED-IL is recommended for recurrent herniation within 2 weeks before adhesion progresses.
Sutureless versus Hand-Sewn Coronary Anastomoses: A Systematic Review and Meta-Analysis
Authors: Hoogewerf Marieke , Schuurkamp Jeroen , Kelder Johannes C. , Jacobs Stephan , Doevendans Pieter A.
Published: January 2022

Background: Sutureless coronary anastomotic devices are intended to facilitate minimally invasive coronary artery bypass grafting (MICS-CABG) by easing and eventually standardizing the anastomotic technique. Within this systematic review and meta-analysis, we aim to determine patency and to evaluate safety outcomes for the sutureless anastomoses. Methods: CENTRAL, MEDLINE, and EMBASE were searched from database start till August 2021 in a predefined search strategy combining the key concepts: ‘coronary artery bypass grafting’, ‘sutureless coronary anastomoses’, and ‘hand-sewn coronary anastomoses’ by the Boolean operation ‘AND’. Study characteristics, patient demographics, interventional details, and all available outcome data were extracted. A meta-analysis was performed on patency at longest follow-up. Safety outcomes were presented. Results: A total of eleven trials towards six sutureless anastomotic devices were included, comprising 3724 patients (490 sutureless and 3234 hand-sewn). There was no significant difference in patency at a mean follow-up duration of 546.3 (range 1.5–2691) days, with a risk ratio of 0.77 (95% CI 0.55–1.06). MACE was reported in 4.5% sutureless and 3.9% hand-sewn patients, including all-cause mortality (resp. 1.3 vs. 1.9%), myocardial infarction (resp. 1.6 vs. 1.7%), and coronary revascularization (resp. 1.8 vs. 0.5%). Incomplete hemostasis occurred in 24.8% of the sutureless anastomoses. Intra-operative device failure forced conversion to hand-sewn or redo-anastomosis in 5.8% of the sutureless cases. Conclusion: Based on the systematic review and meta-analysis including six devices, we conclude that sutureless coronary anastomotic devices appear safe and effective when used by well-trained and dedicated surgical teams.
On the Machining Temperature and Hole Quality of CFRP Laminates When Using Diamond-Coated Special Drills
Authors: Xu Jinyang , Lin Tieyu , Davim Joao Paulo
Published: February 2022

Carbon fiber reinforced polymers (CFRPs) are attractive engineering materials in the modern aerospace industry, but possess extremely poor machinability because of their inherent anisotropy and heterogeneity. Although substantial research work has been conducted to understand the drilling behavior of CFRPs, some critical aspects related to the machining temperature development and its correlations with the process parameters still need to be addressed. The present paper aims to characterize the temperature variation and evolution during the CFRP drilling using diamond-coated candlestick and step tools. Progression of the composite drilling temperatures was recorded using an infrared thermography camera, and the hole quality was assessed in terms of surface morphologies and hole diameters. The results indicate that the maximum drilling temperature tends to be reached when the drill edges are fully engaged into the composite workpiece. Then it drops sharply as the tool tends to exit the last fiber plies. Lower cutting speeds and lower feed rates are found to favor the reduction of the maximum composite drilling temperature, thus reducing the risk of the matrix glass transition. The candlestick drill promotes lower magnitudes of drilling temperatures, while the step drill yields better surface morphologies and more consistent hole diameters due to the reaming effects of its secondary step edges.
Unsaturated Polyester-Based Polymer Concrete Containing Recycled Cathode Ray Tube Glass Aggregate
Authors: Malchiodi Beatrice , Siligardi Cristina , Pozzi Paolo
Published: February 2022

Polymer concrete (PC) is a composite construction material that boasts several advantages, such as lightness, low water permeability, high resistance to corrosive environments, and chemical degradation. Consequently, it has recently attracted interest as an alternative material to the traditional ones for several civil applications. In this study, unsaturated polyester resin was considered the matrix phase of PC. Aimed to produce green PC, the commonly dispersed phase of natural aggregate was totally replaced by recycled glass aggregate (RGA) deriving from cathode ray tube (CRT) glass waste. Fine and coarse fractions of non-hazardous CRT glass were considered in different ratios. Chemical and physical analyses were carried out through XRF, particle size distribution and microstructural analysis to characterize RGA. The influence of RGA particle size and percentage on PC performance was investigated by microstructural analysis and aggregate packing, chemical resistance, water absorption, and mechanical analyses, such as bending, impact, and scratch test. Using solely the coarse fraction of RGA led to the manufacturing of a green PC with similar performance to the traditional PC and in addition lower in density. The PC quality mainly depended on the matrix crosslinking which, for PC containing fine RGA, was promoted by adding 4 wt% of silane coupling agent.
Effects of Silver Diamine Nitrate and Silver Diamine Fluoride on Dentin Remineralization and Cytotoxicity to Dental Pulp Cells: An In Vitro Study
Authors: Srisomboon Surapong , Kettratad Matana , Stray Andrew , Pakawanit Phakkhananan , Rojviriya Catleya , Patntirapong Somying , Panpisut Piyaphong
Published: February 2022

Silver diamine nitrate (SDN) is expected to help control caries similar to silver diamine fluoride (SDF). The aim of this study was to determine the mineral precipitation in demineralized dentin and the cytotoxicity of SDN and SDF to dental pulp cells. Demineralized dentin specimens were prepared, and SDF, SDN, or water (control) was applied. The specimens were then remineralized in simulated body fluid for 2 weeks. The mineral precipitation in the specimens was examined using FTIR-ATR, SEM-EDX, and synchrotron radiation X-ray tomographic microscopy (SRXTM). Additionally, the cytotoxicity of SDF and SDN to human dental pulp stem cells was analyzed using an MTT assay. The increase in FTIR spectra attributable to apatite formation in demineralized dentin in the SDF group was significantly higher compared to the SDN and control groups (p < 0.05). Dentinal tubule occlusion by the precipitation of silver salts was detected in both SDF and SDN groups. The mineral density as shown in SRXTM images and cytotoxicity of both SDN and SDF groups were comparable (p > 0.05). In conclusion, SDF demonstrated superior in vitro apatite formation compared to SDN. However, the degree of mineral precipitation and cytotoxic effects of both were similar.
Is Muscle Architecture Different in Athletes with a Previous Hamstring Strain? A Systematic Review and Meta-Analysis
Authors: Kellis Eleftherios , Sahinis Chrysostomos
Published: February 2022

Hamstring strains are a frequent injury in sports and are characterized by a high recurrence rate. The aim of this review was to examine the muscle and tendon architecture in individuals with hamstring injury. A systematic literature search in four databases yielded eleven studies on architecture following injury. Differences in the fascicle length (FL), pennation angle (PA) and muscle size measures (volume, thickness and physiological cross-sectional area) at rest were not significantly different between the previously injured limb and the contralateral limb (p > 0.05). There was moderate evidence that biceps femoris long head (BFlh) FL shortening was greater during contraction in the injured compared to the contralateral limb. The BFlh FL was smaller in athletes with a previous injury compared to uninjured individuals (p = 0.0015) but no differences in the FL and PA of other muscles as well as in the aponeurosis/tendon size were observed (p > 0.05). An examination of the FL of both leg muscles in individuals with a previous hamstring strain may be necessary before and after return to sport. Exercises that promote fascicle lengthening of both injured and uninjured leg muscles may be beneficial for athletes who recover from a hamstring injury.
Microstructure Evolution in Inconel 718 Produced by Powder Bed Fusion Additive Manufacturing
Authors: Schneider Judy , Farris Laura , Nolze Gert , Reinsch Stefan , Cios Grzegorz , Tokarski Tomasz , Thompson Sean
Published: January 2022

Inconel 718 is a precipitation strengthened, nickel-based super alloy of interest for the Additive Manufacturing (AM) of low volume, complex parts to reduce production time and cost compared to conventional subtractive processes. The AM process involves repeated rapid melting, solidification and reheating, which exposes the material to non-equilibrium conditions that affect elemental segregation and the subsequent formation of solidification phases, either beneficial or detrimental. These variations are difficult to characterize due to the small length scale within the micron sized melt pool. To understand how the non-equilibrium conditions affect the initial solidification phases and their critical temperatures, a multi-length scale, multi modal approach has been taken to evaluate various methods for identifying the initial phases formed in the as-built Inconel 718 produced by laser-powder bed fusion (L-PBF) additive manufacturing (AM). Using a range of characterization tools from the bulk differential thermal analysis (DTA) and x-ray diffraction (XRD) to spatially resolved images using a variety of electron microscopy tools, a better understanding is obtained of how these minor phases can be properly identified regarding the amount and size, morphology and distribution. Using the most promising characterization techniques for investigation of the as-built specimens, those techniques were used to evaluate the specimens after various heat treatments. During the sequence of heat treatments, the initial as-built dendritic structures recrystallized into well-defined grains whose size was dependent on the temperature. Although the resulting strength was similar in all heat treated specimens, the elongation increased as the grain size was refined due to differences in the precipitated phase distribution and morphology.
Acknowledgment to Reviewers of JMSE in 2021
Authors:   JMSE Editorial Office
Published: January 2022

Rigorous peer-reviews are the basis of high-quality academic publishing [...]
Applying Surfactin in the Removal of Blooms of Karlodinium veneficum Increases the Toxic Potential
Authors: Tian Xiaoyu , Meng Ran , Zhou Chengxu , Pan Yuanbo , Yan Xiaojun
Published: February 2022

Biosurfactant has potential application value in the removal of microalgal blooms, but the ecological risks require more research. In this paper, the effects of surfactin on the toxic dinoflagellate Karlodinium veneficum were studied. The coaction of surfactin and K. veneficum was also evaluated through toxicological experiments on Artemia and juvenile clams. The results showed that: (1) in the concentration range of 0–10 mg/L, surfactin significantly killed algal cells in a dose-dependent manner within 48 h; the 24 h EC50 was 3.065 mg/L; (2) K. veneficum had the ability to restore population growth after stress reduction and the restored proliferation was positively correlated with the initial surfactin concentration; (3) the ability to restore population growth was associated with protection afforded by the promotion of antioxidant enzymes, including catalase (CAT), peroxidase (POD) and superoxide dismutase (SOD), whose increase was positively correlated with the surfactin concentration; (4) the toxicity of the coculture of surfactin and K. veneficum was significantly greater than that of the K. veneficum culture or surfactin alone and was dose and time dependent. The potential ecological risks should be considered when applying biosurfactants, such as surfactin, in the removal of harmful algal blooms.
Sero-Epidemiology of Pneumocystis Infection among Infants, Children, and Adults in Chile
Authors: Miller Robert F. , Daly Kieran R. , Walzer Peter D. , Ulloa Ana V. , Ponce Carolina A. , Vargas Sergio L.
Published: January 2022

Previous serologic surveys show >80% of infants in Chile have anti-Pneumocystis antibodies by 2 years of age, but the seroepidemiology of Pneumocystis infection beyond infancy is unknown. We describe the sero-epidemiology in infants, children, and adults at different locations in Chile. Serum samples were prospectively obtained from 681 healthy adults (age ≥ 17 years) and 690 non-immunocompromised infants/children attending eight blood banks or outpatient clinics (2 in Santiago) in Chile. ELISA was used to measure serum IgM and IgG antibodies to Pneumocystis jirovecii major surface antigen (Msg) constructs MsgA and MsgC1. Serologic responses to Pneumocystis Msg showed a high frequency of reactivity, inferring infection. Among infants/children increasing age and the proportion with detectable IgM responses to MsgA, and IgG responses to MsgA, and MsgC1 were positively associated. Among adults there was almost universal seropositivity to one or more Pneumocystis Msg constructs. In infants and children rates of detectable IgM responses to MsgC1 and MsgA were greater than IgG responses. In Santiago, rates of seropositivity among infants/children were greater in clinics located in a more socio-economically deprived part of the city. In Chile, a serological response to Pneumocystis Msg constructs was common across ages regardless of geographical location and climatic conditions. Observed higher rates of IgM responses than IgG responses is consistent with concept of recent/ongoing exposure to Pneumocystis in children and adults. Higher rates of seropositivity in infants/children residing in more densely populated areas of Santiago infers crowding poses an increased risk of transmission.
How Genetics Can Improve Clinical Practice in Chronic Kidney Disease: From Bench to Bedside
Authors: Piras Doloretta , Lepori Nicola , Cabiddu Gianfranca , Pani Antonello
Published: February 2022

Chronic kidney disease (CKD) is considered a major global health problem with high socio-economic costs: the risk of CKD in individuals with an affected first degree relative has been found to be three times higher than in the general population. Genetic factors are known to be involved in CKD pathogenesis, both due to the possible presence of monogenic pathologies as causes of CKD, and to the role of numerous gene variants in determining susceptibility to the development of CKD. The genetic study of CKD patients can represent a useful tool in the hands of the clinician; not only in the diagnostic and prognostic field, but potentially also in guiding therapeutic choices and in designing clinical trials. In this review we discuss the various aspects of the role of genetic analysis on clinical management of patients with CKD with a focus on clinical applications. Several topics are discussed in an effort to provide useful information for daily clinical practice: definition of susceptibility to the development of CKD, identification of unrecognized monogenic diseases, reclassification of the etiological diagnosis, role of pharmacogenetics.
Differential Expression of RAD51AP1 in Ovarian Cancer: Effects of siRNA In Vitro
Authors: Filipe Alice , Katopodis Periklis , Chudasama Dimple , Kerslake Rachel , Jeyaneethi Jeyarooban , Anikin Vladimir , Silva Elisabete , Kyrou Ioannis , Randeva Harpal S. , Sisu Cristina , Hall Marcia , Karteris Emmanouil
Published: February 2022

Background: DNA double strand breaks can affect genome integrity potentially leading to cancer. RAD51-associated protein 1 (RAD51AP1), an accessory protein to RAD51, is critical for homologous recombination, a key DNA damage response pathway. Emerging studies indicate a novel role for RAD51AP1 in carcinogenesis. Here we provide additional insight into the role of RAD51AP1 in ovarian cancer (OvCa). Methods: Gene expression and patient phenotype data were obtained from TCGA and GTEX project consortia for bioinformatics analysis. Immunohistochemistry of OvCa tissue microarray was undertaken. Functional analyses were performed in a SKOV3 OvCa cell line with down-regulation of RAD51AP1 using siRNA. Results: RAD51AP1 is overexpressed at gene level in primary and recurrent OvCa compared to controls. At protein level, RAD51AP1 was up-regulated in low grade serous tumors compared to high grade OvCa. There was higher expression of RAD51AP1 in OvCa metastatic to lymph nodes compared to primary cancer samples. Gene enrichment analyses identified 12 differentially expressed genes (DEGs) related to OvCa, eight of which are also common in tissue from patients with type 2 diabetes mellitus (T2DM). Conclusions: RAD51AP1 is overexpressed in OvCa, Given the link between OvCa and T2DM, the eight-gene signature shows potential for predictive value.
Language-Internal Reanalysis of Clitic Placement in Heritage Grammars Reduces the Cost of Computation: Evidence from Bulgarian
Authors: Ivanova-Sullivan Tanya , Sekerina Irina A. , Tofighi Davood , Polinsky Maria
Published: January 2022

The study offers novel evidence on the grammar and processing of clitic placement in heritage languages. Building on earlier findings of divergent clitic placement in heritage European Portuguese and Serbian, this study extends this line of inquiry to Bulgarian, a language where clitic placement is subject to strong prosodic constraints. We found that, in heritage Bulgarian, clitic placement is processed and rated differently than in the baseline, and we asked whether such clitic misplacement results from the transfer from the dominant language or follows from language-internal reanalysis. We used a self-paced listening task and an aural acceptability rating task with 13 English-dominant, highly proficient heritage speakers and 22 monolingual speakers of Bulgarian. Heritage speakers of Bulgarian process and rate the grammatical proclitic and ungrammatical enclitic clitic positions as equally acceptable, and we contend that this pattern is due to language-internal reanalysis. We suggest that the trigger for such reanalysis is the overgeneralization of the prosodic Strong Start Constraint from the left edge of the clause to any position in the sentence.
Bim Expression Promotes the Clearance of Mononuclear Phagocytes during Choroidal Neovascularization, Mitigating Scar Formation in Mice
Authors: Wang Shoujian , Zaitoun Ismail S. , Darjatmoko Soesiawati R. , Sheibani Nader , Sorenson Christine M.
Published: January 2022

Inflammation is increasingly recognized as an important modulator in the pathogenesis of neovascular age-related macular degeneration (nAMD). Although significant progress has been made in delineating the pathways that contribute to the recruitment of inflammatory cells and their contribution to nAMD, we know little about what drives the resolution of these inflammatory responses. Gaining a better understanding of how immune cells are cleared in the choroid will give a novel insight into how sustained inflammation could influence the pathogenesis of nAMD. The pro-apoptotic Bcl-2 family member Bim is a master regulator of immune cell homeostasis. In its absence, immune cell lifespan and numbers increase. Most therapeutic regimes that squelch inflammation do so by enhancing immune cell apoptosis through enhanced Bim expression and activity. To test the hypothesis that Bim expression tempers inflammation during the pathogenesis of nAMD, we used the mouse laser-induced choroidal neovascularization (CNV) model in which inflammation acts as a facilitator of CNV. Here, we showed minimal to no change in the recruitment of F4/80-, CD80-, CD11b-, and Iba1-positive myeloid-derived mononuclear phagocytes to the site of laser photocoagulation in the absence of Bim expression. However, the resolution of these cells from the choroid of Bim-deficient (Bim -/-) mice was significantly diminished following laser photocoagulation. With time, we noted increased scar formation, demonstrated by collagen I staining, in Bim -/- mice with no change in the resolution of neovascularization compared to wild-type littermates. We also noted that mice lacking Bim expression in mononuclear phagocytes (BimFlox/Flox; Lyz2-Cre (BimMP) mice) had delayed resolution of F4/80-, CD80-, CD11b-, and Iba1-positive cells, while those lacking Bim expression in endothelial cells (BimFlox/Flox; Cad5-Cre (BimEC) mice) had delayed resolution of only CD11b- and Iba1-positive cells. Both BimMP and BimEC mice demonstrated increased scar formation, albeit to differing degrees. Thus, our studies show that resolving inflammation plays an important role in moderating scar formation in nAMD, and it is impacted by Bim expression in both the endothelium and mononuclear phagocyte lineages.