bluuebunny/crossref_metadata_2025 huggingface dataset:
Functional Coupling of the Locus Coeruleus Is Linked to Successful Cognitive Control
Authors: Grueschow Marcus , Kleim Birgit , Ruff Christian Carl
Published: February 2022

The locus coeruleus (LC) is a brainstem structure that sends widespread efferent projections throughout the mammalian brain. The LC constitutes the major source of noradrenaline (NE), a modulatory neurotransmitter that is crucial for fundamental brain functions such as arousal, attention, and cognitive control. This role of the LC-NE is traditionally not believed to reflect functional influences on the frontoparietal network or the striatum, but recent advances in chemogenetic manipulations of the rodent brain have challenged this notion. However, demonstrations of LC-NE functional connectivity with these areas in the human brain are surprisingly sparse. Here, we close this gap. Using an established emotional stroop task, we directly compared trials requiring response conflict control with trials that did not require this, but were matched for visual stimulus properties, response modality, and controlled for pupil dilation differences across both trial types. We found that LC-NE functional coupling with the parietal cortex and regions of the striatum is substantially enhanced during trials requiring response conflict control. Crucially, the strength of this functional coupling was directly related to individual reaction time differences incurred by conflict resolution. Our data concur with recent rodent findings and highlight the importance of converging evidence between human and nonhuman neurophysiology to further understand the neural systems supporting adaptive and maladaptive behavior in health and disease.
Stereotactic Body Radiation Therapy in Patients with Oligometastatic Disease: Clinical State of the Art and Perspectives
Authors: Kinj Rémy , Muggeo Emilien , Schiappacasse Luis , Bourhis Jean , Herrera Fernanda G.
Published: February 2022

Stereotactic body radiation therapy (SBRT) is a form of radiation therapy (RT) in which a small number of high doses of radiation are delivered to a target volume using highly sophisticated equipment. Stereotactic body radiation therapy is crucial in two cancer stages: early primary cancer and oligometastatic disease, with the goal of inducing complete cancer remission in both. This treatment method is commonly used to treat a variety of disease types. Over the years, a growing body of clinical evidence on the use of SBRT for the treatment of primary and metastatic tumors has accumulated, with efficacy and safety demonstrated in randomized clinical trials. This article will review the technical and clinical aspects of SBRT according to disease type and clinical indication.
STAT1 and STAT3 Exhibit a Crosstalk and Are Associated with Increased Inflammation in Hepatocellular Carcinoma
Authors: Ploeger Carolin , Schreck Johannes , Huth Thorben , Fraas Angelika , Albrecht Thomas , Charbel Alphonse , Ji Junfang , Singer Stephan , Breuhahn Kai , Pusch Stefan , Köhler Bruno Christian , Springfeld Christoph , Schirmacher Peter , Mehrabi Arianeb , Goeppert Benjamin , Roessler Stephanie
Published: February 2022

Liver cancers, which are mostly hepatocellular carcinoma (HCC) and cholangiocarcinoma (CCA), are very aggressive tumors with poor prognosis. Therapeutic options with curative intent are largely limited to surgery and available systemic therapies show limited benefit. Signal transducer and activator of transcription 1 (STAT1) and 3 (STAT3) are key transcription factors activated by pro-inflammatory cytokines such as interferon-γ (IFN-γ) and interleukin-6 (IL-6). In this study, we combined in vitro cell culture experiments and immunohistochemical analyses of human HCC (N = 124) and CCA (N = 138) specimens. We observed that in the absence of STAT3, IL-6 induced the activation of STAT1 and its target genes suggesting that IL-6 derived from the tumor microenvironment may activate both STAT1 and STAT3 target genes in HCC tumor cells. In addition, STAT1 and STAT3 were highly activated in a subset of HCC, which exhibited a high degree of infiltrating CD8- and FOXP3-positive immune cells and PD-L1 expression. Our results demonstrate that STAT1 and STAT3 are expressed and activated in HCC and tumor infiltrating immune cells. In addition, HCC cases with high STAT1 and STAT3 expression also exhibited a high degree of immune cell infiltration, suggesting increased immunological tolerance.
Long-Term Use of Proton Pump Inhibitors in Cancer Patients: An Opinion Paper
Authors: Raoul Jean-Luc , Edeline Julien , Simmet Victor , Moreau-Bachelard Camille , Gilabert Marine , Frénel Jean-Sébastien
Published: February 2022

Multikinase inhibitors (MKIs), and particularly tyrosine kinase inhibitors (TKIs) and immune checkpoint inhibitors (CPIs), are currently some of the major breakthroughs in cancer treatment. Proton pump inhibitors (PPIs) revolutionised the treatment of acid-related diseases, but are frequently overused for epigastric pain or heartburn. However, long-term acid suppression from using PPIs may lead to safety concerns, and could have a greater impact in cancer patients undergoing therapy, like bone fractures, renal toxicities, enteric infections, and micronutrient deficiencies (iron and magnesium). Moreover, acid suppression may also affect the pharmacokinetics of drugs (at least during acid suppression) and decrease the absorption of many molecularly-targeted anticancer therapies, which are mostly weak bases with pH-dependent absorption. This type of drug-drug interaction may have detrimental effects on efficacy, with major clinical impacts described for some orally administrated targeted therapies (erlotinib, gefitinib, pazopanib, palbociclib), and conflicting results with many others, including capecitabine. Furthermore, the long-term use of PPIs results in severe alterations to the gut microbiome and recent retrospective analyses have shown that the benefit of using CPIs was suppressed in patients treated with PPIs. These very expensive drugs are of great importance because of their efficacy. As the use of PPIs is not essential, we must apply the precautionary principle. All these data should encourage medical oncologists to refrain from prescribing PPIs, explaining to patients the risks of interaction in order to prevent inappropriate prescription by another physician.
Reduced Absolute Count of Monocytes in Patients Carrying Hematological Neoplasms and SARS-CoV2 Infection
Authors: Romano Alessandra , Cerchione Claudio , Conticello Concetta , Filetti Sabina , Bulla Anna , Chiarenza Annalisa , Del Fabro Vittorio , Leotta Salvatore , Markovic Uros , Motta Giovanna , Parisi Marina , Stagno Fabio , Palumbo Giuseppe Alberto , Di Raimondo Francesco
Published: February 2022

Background: Clinical course of COVID-19 depends on several patient-specific risk factors, including immune function, that is largely compromised in cancer patients. Methods: We prospectively evaluated 120 adult consecutive patients (including 34 cases of COVID-19 breakthrough after two full doses of BNT162b2 vaccine) with underlying hematological malignancies and a SARS-CoV-2 infection, in terms of patient’s clinical outcome. Results: Among fully vaccinated patients the achievement of viral clearance by day 14 was more frequent than in unvaccinated patients. Increased 30-day mortality was associated with presence of active/progressing disease and absolute monocyte count lower than 400 cells/uL. Results of multivariable analysis in unvaccinated patients showed that the pre-infection absolute count of monocytes less or equal to 400 cells/mmc, active or progressive disease of the underlying hematological malignancy, the COVID-19 severity identified by hospitalization requirement and lack of viral clearance at 14 days were independent predictors of 1-year overall survival. Conclusions: Taken together, our results indicate that absolute monocyte count determined one month before any documented SARS-CoV-2 infection could identify patients affected by hematological neoplasms with increased risk of inferior overall survival.
Trends in Diagnosing Obstructive Sleep Apnea in Pediatrics
Authors: Kang Mandip , Mo Fan , Witmans Manisha , Santiago Vicente , Tablizo Mary Anne
Published: February 2022

Obstructive sleep apnea in children has been linked with behavioral and neurocognitive problems, impaired growth, cardiovascular morbidity, and metabolic consequences. Diagnosing children at a young age can potentially prevent significant morbidity associated with OSA. Despite the importance of taking a comprehensive sleep history and performing thorough physical examination to screen for signs and symptoms of OSA, these findings alone are inadequate for definitively diagnosing OSA. In-laboratory polysomnography (PSG) remains the gold standard of diagnosing pediatric OSA. However, there are limitations related to the attended in-lab polysomnography, such as limited access to a sleep center, the specialized training involved in studying children, the laborious nature of the test and social/economic barriers, which can delay diagnosis and treatment. There has been increasing research about utilizing alternative methods of diagnosis of OSA in children including home sleep testing, especially with the emergence of wearable technology. In this article, we aim to look at the presentation, physical exam, screening questionnaires and current different modalities used to aid in the diagnosis of OSA in children.
Psychosocial Distress Due to Interference of Normal Developmental Milestones in AYAs with Cancer
Authors: Itzep Nelda , Roth Michael
Published: February 2022

Cancer in the adolescent and young adult phase poses additional challenges to this period of development that is crucial to the transition to independence. This report provides a brief review of normal developmental milestones in this age range while highlighting the disruptive effects of cancer. We focus on the psychological burden of cancer in patients aged 15–39 years and explore the application of the total pain model to highlight the psychological/emotional, social, and spiritual aspects of non-physical pain. We also briefly review posttraumatic growth and resilience. Lastly, we provide a review of areas for possible development and future research.
Stability of Rhodamine Lactone Cycle in Solutions: Chain–Ring Tautomerism, Acid–Base Equilibria, Interaction with Lewis Acids, and Fluorescence
Authors: Obukhova Olena M. , Mchedlov-Petrossyan Nikolay O. , Vodolazkaya Natalya A. , Patsenker Leonid D. , Doroshenko Andrey O.
Published: February 2022

The equilibrium between different tautomers that can be colored or colorless is an important feature for rhodamine dyes. Presently, this phenomenon is mostly discussed for rhodamine B. Herein, we studied the tautomerism and acid–base dissociation (HR+ ⇄ R + H+) of a set of rhodamines in organic media. Form R is an equilibrium mixture of the colored zwitterion R± and colorless lactone R0. Absorption spectra in 90 mass% aqueous acetone reflects the correlation between the dyes structure and the equilibrium constant, KT = [R0]/[R±]. Increase in the pKa value on transferring from water to organic solvents confirms the highly polar character of the R± tautomer. To reveal the role of the solvent nature, the tautomerism of an asymmetrical rhodamine, 2-(12-(diethyliminio)-2,3,5,6,7,12-hexahydro-1H-chromeno[2,3-f]pyrido[3,2,1-ij]quinolin-9-yl)benzoate, was examined in 14 media. This chain–ring tautomerism is an intramolecular acid–base reaction; the central carbon atom acts as a Lewis acid. The interaction with other Lewis acids, Li+, Ca2+, Mg2+, and La3+, results in rupture of lactone cycle. In polar solvents, lactones undergo photocleavage resulting in formation of highly fluorescent R±, whereas the blue fluorescence and abnormally high Stokes shift in low-polar media may be explained either by another photoreaction or by spiroconjugation and charge transfer in the exited state.
Melanin-Binding Colorants: Updating Molecular Modeling, Staining and Labeling Mechanisms, and Biomedical Perspectives
Authors: Stockert Juan C. , Espada Jesús , Blázquez-Castro Alfonso
Published: February 2022

Melanin and melanoma tumors are two fields of increasing interest in biomedical research. Melanins are ubiquitous biopigments with adaptive value and multiple functions, and occur in the malignant melanoma. Although several chemical structures have been proposed for eumelanin, molecular modeling and orbitals indicate that a planar or spiral benzoquinone-porphycene polymer would be the model that better explains the broad-band light and ultrasound absorption, electric conductivity, and graphite-like organization shown by X-ray crystallography and electron microscopy. Lysosomes and melanosomes are selectively labeled by vital probes, and melanin also binds to metal cations, colorants, and drugs, with important consequences in pharmacology, pathology, and melanoma therapy. In addition to traditional and recent oncologic treatments, photodynamic, photothermal, and ultrasound protocols represent novel modalities for melanoma therapy. Since eumelanin is practically the ideal photothermal and ultrasound sensitizer, the vibrational decay from photo-excited electrons after NIR irradiation, or the electrochemical production of ROS and radicals after ultrasound absorption, induce an efficient heating or oxidative response, resulting in the damage and death of tumor cells. This allows repetitive treatments due to the remaining melanin contained in tumoral melanophages. Given that evolution and prognosis of the advanced melanoma is still a concern, new biophysical procedures based on melanin properties can now be developed and applied.
The Role of Surgical Approaches in the Multi-Modal Management of Adult Craniopharyngiomas
Authors: Hong Christopher S. , Omay Sacit Bulent
Published: February 2022

Craniopharyngiomas are rare, benign primary brain tumors that arise from remnants of the craniopharyngeal duct epithelium within the sellar and suprasellar region. Despite their benign biology, they may cause significant morbidity, secondary to involvement of nearby eloquent neural structures, such as the pituitary gland, hypothalamus, and optic apparatus. Historically, aggressive surgical resection was the treatment goal to minimize risk of tumor recurrence via open transcranial midline, anterolateral, and lateral approaches, but could lead to clinical sequela of visual, endocrine, and hypothalamic dysfunction. However, recent advances in the endoscopic endonasal approach over the last decade have mostly supplanted transcranial surgery as the optimal surgical approach for these tumors. With viable options for adjuvant radiation therapy, targeted medical treatment, and alternative minimally invasive surgical approaches, the management paradigm for craniopharyngiomas has shifted from aggressive open resection to more minimally invasive but maximally safe resection, emphasizing quality of life issues, particularly in regards to visual, endocrine, and hypothalamic function. This review provides an update on current multi-modal approaches for craniopharyngiomas, highlighting the modern surgical treatment paradigm for this disease entity.
An Improved Hidden Markov Model for Monitoring the Process with Autocorrelated Observations
Authors: Li Yaping , Li Haiyan , Chen Zhen , Zhu Ying
Published: February 2022

With the development of intelligent manufacturing, automated data acquisition techniques are widely used. The autocorrelations between data that are collected from production processes have become more common. Residual charts are a good approach to monitoring the process with data autocorrelation. An improved hidden Markov model (IHMM) for the prediction of autocorrelated observations and a new expectation maximization (EM) algorithm is proposed. A residual chart based on IHMM is employed to monitor the autocorrelated process. The numerical experiment shows that, in general, IHMMs outperform both conventional hidden Markov models (HMMs) and autoregressive (AR) models in quality shift diagnosis, decreasing the cost of missing alarms. Moreover, the times taken by IHMMs for training and prediction are found to be much less than those of HMMs.
Blocking IbmiR319a Impacts Plant Architecture and Reduces Drought Tolerance in Sweet Potato
Authors: Ren Lei , Zhang Tingting , Wu Haixia , Ge Xinyu , Wan Huihui , Chen Shengyong , Li Zongyun , Ma Daifu , Wang Aimin
Published: February 2022

MicroRNA319 (miR319) plays a key role in plant growth, development, and multiple resistance by repressing the expression of targeted TEOSINTE BRANCHED/CYCLOIDEA/PCF (TCP) genes. Two members, IbmiR319a and IbmiR319c, were discovered in the miR319 gene family in sweet potato (Ipomoea batatas [L.] Lam). Here, we focused on the biological function and potential molecular mechanism of the response of IbmiR319a to drought stress in sweet potato. Blocking IbmiR319a in transgenic sweet potato (MIM319) resulted in a slim and tender phenotype and greater sensitivity to drought stress. Microscopic observations revealed that blocking IbmiR319a decreased the cell width and increased the stomatal distribution in the adaxial leaf epidermis, and also increased the intercellular space in the leaf and petiole. We also found that the lignin content was reduced, which led to increased brittleness in MIM319. Quantitative real-time PCR showed that the expression levels of key genes in the lignin biosynthesis pathway were much lower in the MIM319 lines than in the wild type. Ectopic expression of IbmiR319a-targeted genes IbTCP11 and IbTCP17 in Arabidopsis resulted in similar phenotypes to MIM319. We also showed that the expression of IbTCP11 and IbTCP17 was largely induced by drought stress. Transcriptome analysis indicated that cell growth-related pathways, such as plant hormonal signaling, were significantly downregulated with the blocking of IbmiR319a. Taken together, our findings suggest that IbmiR319a affects plant architecture by targeting IbTCP11/17 to control the response to drought stress in sweet potato.
Sorbitol Reduces Sensitivity to Alternaria by Promoting Ceramide Kinases (CERK) Expression through Transcription Factor Pswrky25 in Populus (Populus simonii Carr.)
Authors: Qi Meng , Wu Rui , Song Zhihua , Dong Biying , Chen Ting , Wang Mengying , Cao Hongyan , Du Tingting , Wang Shengjie , Li Na , Yang Qing , Fu Yujie , Meng Dong
Published: February 2022

Sugar, acting as a signal, can regulate the production of some chemical substance during plant defense responses. However, the molecular basis and regulatory mechanisms of sugar in poplar and other forest trees are still unclear. Sorbitol is a sugar-signaling molecule associated with plant defense. In this study, the pathogen-infested status of poplar was alleviated after exogenous feeding of 50 mM sorbitol. We sequenced and analyzed the transcriptome of poplar leaves before and after inoculation. The results showed that the genes PR1, WRKY, ceramide kinases (CERK) and so on responded to sorbitol feeding and pathogen infestation. We screened for genes related to disease resistance such as PsWRKY25 and PsCERK1 and found that significant disease spots occurred on day six of strep throat infestation. Under sorbitol feeding conditions, the appearance of spots was delayed after the pathogen inoculation. Due to the overexpression of PsWRKY25, the overexpression of PsCERK1 triggered the defense response in poplar. This was also confirmed by PsWRKY25 overexpression experiments. These findings present new insights into the influence of sorbitol on Populus simonii Carr. disease resistance. These results emphasize the value of molecular phenotypes in predicting physiological changes.
The Investigation of Phenylalanine, Glucosinolate, Benzylisothiocyanate (BITC) and Cyanogenic Glucoside of Papaya Fruits (Carica papaya L. cv. ‘Tainung No. 2’) under Different Development Stages between Seasons and Their Correlation with Bitter Taste
Authors: Jioe Irvan Prawira Julius , Lin Huey-Ling , Shiesh Ching-Chang
Published: February 2022

Papaya fruit is one of economic crops in Taiwan, mostly eaten as table fruits. In some Asian countries, unripe papaya fruit is eaten as salad and this led to trends in Taiwan as well. However, unripe papaya fruit may taste bitter during cool seasons. Glucosinolate and cyanogenic glucoside are among the substances that cause bitter taste in many plants, which can also be found in papaya. However, there is still no report about the relationship between seasons and bitter taste in papaya fruits. Thus, the purpose of this study is to investigate the glucosinolate biosynthesis and its correlation between bitterness intensity during cool and warm seasons. The bitterness intensity was highest at the young fruit stage and decreased as it developed. In addition, the bitterness intensity in cool season fruits is higher than in warm season fruits. Cyanogenic glucoside and BITC content showed negative correlation with bitterness intensity (r = −0.54 ***; −0.46 ***). Phenylalanine showed positive correlation with bitterness intensity (r = 0.35 ***), but its content did not reach the bitterness threshold concentration, which suggested that phenylalanine only acts as cyanogenic glucoside and glucosinolate precusors. Glucosinolate content showed positive correlation with bitterness intensity at different developmental stages (r = 0.805 ***). However, the correlation value in different lines/cultivars decreased (0.44 ***), suggesting that glucosinolate was not the only substance that caused bitter taste in immature papaya fruits.
A Comparative Evaluation of Hydromorphological Assessment Methods Applied in Rivers of Greece
Authors: Stefanidis Konstantinos , Kouvarda Theodora , Latsiou Anna , Papaioannou George , Gritzalis Konstantinos , Dimitriou Elias
Published: February 2022

The ecological assessment of all surface water bodies in Europe according to the Water Framework Directive involves the monitoring of biological, physicochemical and hydromorphological quality elements. For the hydromorphological assessment in particular, there are numerous methods that have been developed and adopted by EU member countries. With this study, we compared three different methods (River Habitat Survey, Morphological Quality Index and River Hydromorphology Assessment Technique) applied in 122 river reaches that are part of the National Monitoring Network of Greece. The main objectives were (a) to identify whether different assessment systems provide similar classifications of hydromorphological status and (b) to distinguish strengths and weaknesses associated with the implementation of each method. Our results show that the River Hydromorphology Assessment Technique (RHAT) and the Morphological Quality Index (MQI) resulted in the same classification for 58% of the studied reaches, while 34% of the remaining cases differed by only one quality class. Correlations between the two indices per river type (ICT) showed that the two indices were strongly correlated for water courses located at low altitudes. Concerning the HMS index of the River Habitat Survey (RHS), which is an index that reflects the overall hydromorphological pressure, it showed larger differences with the other two indices, mainly because it classified more sites as “Poor” and “Bad” quality classes. Based on our results, we recommend that the two indices, RHAT and MQI, can be implemented complementary to the RHS for providing a rather easy and quick assessment of the overall hydromorphological status, at least until a national hydromorphological database is compiled that will allow for the proper adaptation of the Habitat Quality Assessment (HQA) index.
Evaluation of Happy Sport, an Emotional Education Program for Assertive Conflict Resolution in Sports
Authors: Ros-Morente Agnès , Farré Miriam , Quesada-Pallarès Carla , Filella Gemma
Published: February 2022

Background: Interpersonal conflicts occur in any kind of social relation, including the field of sports. Proper emotional management can improve athletes’ well-being, coexistence, and performance. This study presents the initial results of the gamified emotional education program Happy Sport in a sample of athletes in the field of non-formal education. Methods: The study sample consists of 194 athletes from the benjamín and alevín categories (3rd- to 6th-grade primary school children). A quasi-experimental pre-intervention and post-intervention design with a control group is followed using the Games and Emotions Scale (GES), Social Support Scale, Emotion Regulation Questionnaire for Children and Adolescents (ERQ-CA), and Bullying in Sports Questionnaire. Results: Statistically significant differences were found across participants in the experimental group between the pre- and post-intervention evaluations for the variables satisfaction and bullying. An analysis of the competencies related to emotion regulation revealed significant results for the experimental group for both scales (cognitive reappraisal and expressive suppression). Conclusions: The results show that after a training session with the gamified software Happy Sport, children’s satisfaction increased and bullying levels decreased. Changes in cognitive reappraisal and expressive suppression may also be explained by the training received.
Gamification as a Promoting Tool of Motivation for Creating Sustainable Higher Education Institutions
Authors: Navarro-Espinosa Johanna Andrea , Vaquero-Abellán Manuel , Perea-Moreno Alberto-Jesús , Pedrós-Pérez Gerardo , Martínez-Jiménez Maria del Pilar , Aparicio-Martínez Pilar
Published: February 2022

Higher Educational Institutions (HEIs) are responsible for creating healthy and sustainable environments for students and teachers through diverse educational paradigms such as gamification. In this sense, the Healthy People 2030 and the Sustainable Development Goals indicated the imperative to provide inclusive and equitable quality education to promote a healthy environment and life. The principal objective was to analyse the impact of gamification on health development in HEIs, highlighting their positive and negative effects. To achieve such an objective, a bibliometric analysis was carried out. The 257 documents showed no significant increasing trend in the last decade (p > 0.05) related to the pandemic. Most of the publications were conferences (45%), and the few published articles were the documents with more citations (p < 0.001). According to their index in Journal Citation Reports, there were significant differences between the citations of articles published in journals (p < 0.001). The analysis of journal co-citations showed that the leading journals (such as Computers in Human Behavior) had a significant part in the clusters formed (p < 0.001), conditioning also the keywords, especially the term “motivation”. These findings were discussed, concluding that the experimental studies focused on the teachers’ adverse effects are yet to come.
Perinatal Anxiety among Women during the COVID-19 Pandemic—A Cross-Sectional Study
Authors: Iwanowicz-Palus Grażyna , Mróz Mariola , Korda Aleksandra , Marcewicz Agnieszka , Palus Agnieszka
Published: February 2022

Introduction: The COVID-19 pandemic has changed the way prenatal education and obstetric care are provided. Pandemic-related anxiety, restrictions, limitations in perinatal care, and the inability to be accompanied by a loved one can have negative psychological consequences for future parents and their child. The aim of this study was to analyze the determinants and assess the anxiety of pregnant women in individual trimesters, as well as to learn about the sources of support and medical personnel proceeding methods. Materials and Methods: This research was conducted as a diagnostic survey, using the State-Trait Anxiety Inventory (STAI), Childbirth Anxiety Questionnaire (CAQ), and a standardized interview questionnaire, on 534 pregnant women in Poland. Resultsand Conclusions: The pregnant women, regardless of the trimester of pregnancy, are characterized by: increased anxiety level influenced by the current epidemiological situation, psychophysical condition, previous maternal experiences, participation in classes preparing for childbirth, organization of perinatal care, their relationship with a partner, and the presence of a loved one during childbirth. A negative correlation was shown between the level of childbirth anxiety and maternal experience, as well as the support of a doctor and midwife.
Human Papillomavirus Self-Sampling for Primary Cervical Cancer Screening in Under-Screened Women in Hong Kong during the COVID-19 Pandemic
Authors: Ngu Siew-Fei , Lau Lesley S. K. , Li Justin , Wong Grace C. Y. , Cheung Annie N. Y. , Ngan Hextan Y. S. , Chan Karen K. L.
Published: February 2022

The aim of this study was to assess the effectiveness of HPV self-sampling for cervical cancer screening and the best means of service delivery, with a specific focus on under-screened women, particularly during the COVID-19 pandemic. Using three arms of service delivery (social media, school outreach and underserved outreach), we recruited under-screened women aged 30–65 years from two population groups: the general public and specific underserved communities, from whom self-sampled specimens and optional clinician-sampled cervical specimens were obtained for HPV testing. A total of 521 self-sampling kits were distributed, of which 321 were returned, giving an overall uptake rate of 61.6%. The response rate was higher in the face-to-face underserved outreach (65.5%) compared to social media (22.8%) and school outreach (18.2%). The concordance for HPV detection between self-sampled and clinician-sampled specimens was 90.2% [95% confidence interval (CI) 85.1–93.8%; Cohen’s kappa 0.59 (95% CI 0.42–0.75)]. Overall, 89.2% of women were willing to have self-sampling again. In conclusion, HPV self-sampling is an effective method for cervical cancer screening and can be considered as an option, particularly in women who are reluctant or unable to attend regular screening. Various service deliveries could be considered to increase participation in cervical cancer screening.
Higher Work-Privacy Conflict and Lower Job Satisfaction in GP Leaders and Practice Assistants Working Full-Time Compared to Part-Time: Results of the IMPROVEjob Study
Authors: Göbel Julian , Schmidt Manuela , Seifried-Dübon Tanja , Linden Karen , Degen Lukas , Rind Esther , Eilerts Anna-Lisa , Pieper Claudia , Grot Matthias , Werners Brigitte , Schröder Verena , Jöckel Karl-Heinz , Rieger Monika A. , Weltermann Birgitta M. ,   on behalf of the IMPROVEjob Consortium
Published: February 2022

Background: Work-privacy conflict (WPC) has become an important issue for medical professionals. The cluster-randomized controlled IMPROVEjob study aimed at improving job satisfaction (primary outcome), with additional outcomes such as examining the work-privacy conflict in German general practice personnel. Using baseline data of this study, the relationship between work-privacy conflict and job satisfaction (JS) was analyzed. In addition, factors associated with higher WPC were identified. Methods: At baseline, 366 participants (general practitioners (GPs) in leadership positions, employed general practitioners, and practice assistants) from 60 German practices completed a questionnaire addressing socio-demographic data and job characteristics. Standardized scales from the German version of the COPSOQ III requested data concerning job satisfaction and work-privacy conflict. Both scores range from 0 (lowest) to 100 (highest). Multilevel analysis accounted for the clustered data. Statistical analyses were performed using IBM SPSS and RStudio software, with a significance level set at p < 0.05. Results: Job satisfaction was 77.16 (mean value; SD = 14.30) among GPs in leadership positions (n = 84), 79.61 (SD = 12.85) in employed GPs (n = 28), and 72.58 (SD = 14.42) in practice assistants (n = 254). Mean values for the WPC-scale were higher for professionals with more responsibilities: GPs in leadership positions scored highest with 64.03 (SD = 29.96), followed by employed physicians (M = 45.54, SD =30.28), and practice assistants (M = 32.67, SD = 27.41). General practitioners and practice assistants working full-time reported significantly higher work-privacy conflict than those working part-time (p < 0.05). In a multilevel analysis, work-privacy conflict was significantly associated with job satisfaction (p < 0.001). A multiple regression analysis identified working hours, as well as and being a practice owner or an employed physician as factors significantly influencing WPC. Discussion: WPC was high among general practice leaders and practice personnel working full-time. Future interventions to support practice personnel should focus on reducing WPC, as there is good evidence of its effects on job satisfaction.
A Central Nervous System Focused Treatment Program for People with Frozen Shoulder: A Feasibility Study
Authors: Mena-del Horno Silvia , Dueñas Lirios , Lluch Enrique , Louw Adriaan , Luque-Suarez Alejandro , Mertens Michel GCAM , Fuentes-Aparicio Laura , Balasch-Bernat Mercè
Published: February 2022

Background: Frozen shoulder (FS) is a highly disabling pathology of poorly understood etiology, which is characterized by the presence of intense pain and progressive loss of range of motion (ROM). The aim of this study is to evaluate the feasibility and clinical impact of a CNS-focused treatment program for people with FS. Methods: 10 subjects with primary FS received a 10-week CNS-focused intervention including sensory discrimination training and graded motor imagery techniques delivered as clinic sessions (60 min) and home therapy (30 min five times per week). Measurements were taken at baseline, after a 2-week “washout” period, after treatment, and at three months follow-up. The Shoulder Pain and Disability Index (SPADI) was the primary outcome. Secondary measures were feasibility-related outcomes, self-reported shoulder pain, active and passive range of motion, two-point discrimination threshold (TPDT), left/right judgement task (LRJT), fear-avoidance (Tampa Scale for Kinesiophobia), pain catastrophization (Pain Catastrophizing Scale), and pain sensitization (Central Sensitization Inventory). A Student’s t-test was used to assess the “washout” period. A repeated measure analysis of variance (ANOVA) was used to evaluate within-subjects’ differences for all outcome measures in the different assessment periods and a pairwise analysis was used to compare between the different assessment points. Statistical significance was set at p < 0.05. Results: 70% of participants completed the treatment. No significant changes were found after “washout” period except for TPDT (p = 0.02) and SPADI (p = 0.025). Improvements in self-reported shoulder pain (p = 0.028) and active shoulder flexion (p = 0.016) were shown after treatment (p = 0.028) and follow-up (p = 0.001) and in SPADI at follow-up (p = 0.008). No significant changes were observed in TPDT, LRJT, fear-avoidance, pain catastrophization, and pain sensitization. Conclusions: a CNS-focused treatment program might be a suitable approach to improve pain and disability in FS, but further research is needed to draw firm conclusions.
Subjective Wellbeing and Related Factors of Older Adults Nine and a Half Years after the Great East Japan Earthquake: A Cross-Sectional Study in the Coastal Area of Soma City
Authors: Kinoshita Yuri , Nakayama Chihiro , Ito Naomi , Moriyama Nobuaki , Iwasa Hajime , Yasumura Seiji
Published: February 2022

This study examined older adults’ subjective wellbeing and related factors in the coastal area of Soma City nine and a half years after the Great East Japan Earthquake (GEJE). Data were collected from 65- to 84-year-old residents and 1297 participants via a questionnaire from October to November 2020. The participants were divided into two groups: housing complexes and non-housing complexes. The dependent variable was subjective wellbeing assessed via Lawton’s Philadelphia Geriatric Center Morale Scale (PGCMS). Using multivariate regression analysis, the factors most strongly related to a low PGCMS score for both groups were poor health conditions, difficulties resting while asleep, poor financial wellbeing, inability to chew certain foods, and fear of solitary death. The GEJE experience was further distinguished in the housing complex group by the loss of an important non-family individual; for the other group, important factors were female gender, junior high school education level or lower, limited social networks, and deterioration of a family member’s health. Older adults’ subjective wellbeing in Soma City was low after nine and a half years following the GEJE. For disaster victims and their families in both groups, it is crucial to implement measures such as long-term, continuous physical and mental health support.
Terbinafine Resistance in Dermatophytes: A French Multicenter Prospective Study
Authors: Moreno-Sabater Alicia , Normand Anne-Cécile , Bidaud Anne-Laure , Cremer Geneviève , Foulet Françoise , Brun Sophie , Bonnal Christine , Aït-Ammar Nawel , Jabet Arnaud , Ayachi Aymen , Piarroux Renaud , Botterel Françoise , Houzé Sandrine , Desoubeaux Guillaume , Hennequin Christophe , Dannaoui Eric
Published: February 2022

In recent years, we have moved from the sporadic description of terbinafine-resistant (TerR) Trichophyton spp. isolates to the Indian outbreak due to T. indotineae. Population flows have spread TerR worldwide, altering local epidemiology. We conducted a prospective multicentric study to determine the relative frequency of TerR isolates in France (Paris area) and of the newly introduced T. indotineae species. TerR isolates were screened by the terbinafine-containing-agar-medium (TCAM) method and confirmed by EUCAST. Sequencing methods were used to identify isolates to the species/genotype level and to analyze substitutions in the squalene epoxidase gene (SQLE). In total, 3 isolates out of 580 (T. rubrumn = 1; T. interdigitalen = 1; T. indotineaen = 1) grew on TCAM, showed terbinafine resistance by EUCAST and harbored the Phe397Leu (n = 2) or Leu393Ser (n = 1) substitution in the SQLE. ITS-sequencing of isolates of the T. mentagrophytes/interdigitale complex (n = 125) revealed a relative frequency of 4.8% for T. indotineae and the presence of T. mentagrophytes genotype VII. Despite the detection of terbinafine resistance, isolates from this complex remained susceptible to itraconazole, voriconazole and amorolfine. Terbinafine resistance is present in France and the dermatophyte epidemiology is changing. Efficient systems must be implemented to survey the evolution of newly introduced species and to identify TerR isolates.
A Simplified Ductile Fracture Model for Predicting Ultra-Low Cycle Fatigue of Structural Steels
Authors: Yu Mingming , Xie Xu , Li Shuailing
Published: February 2022

Under strong earthquakes, steel structures are prone to undergoing ultra-low cycle fatigue (ULCF) fracture after sustaining cyclic large-strain loading, leading to severe earthquake-induced damage. Thus, establishing a prediction method for ULCF plays a significant role in the seismic design of steel structures. However, a simple and feasible model for predicting the ULCF life of steel structures has not been recognized yet. Among existing models, the ductile fracture model based on ductility capacity consumption has the advantage of strong adaptability, while the loading history effect in the damage process can also be considered. Nevertheless, such models have too many parameters and are inconvenient for calibration and application. To this end, focusing on the prediction methods for ULCF damage in steel structures, with the fragile parts being in moderate and high stress triaxiality, this paper proposes a simplified uncoupled prediction model that considers the effect of stress triaxiality on damage and introduces a new historical-effect related variable function reducing the calibration work of model parameters. Finally, cyclic loading test results of circular notched specimens verify that the proposed model has the advantages of a small dispersion of parameters for calibration, being handy for application, and possessing reliable results, providing a prediction method for ULCF damage of structural steels.
Designing High Entropy Bulk Metallic Glass (HE-BMG) by Similar Element Substitution/Addition
Authors: Ding Hongyu , Luan Hengwei , Bu Hengtong , Xu Hongjie , Yao Kefu
Published: February 2022

In this paper, we report that two newly designed high entropy bulk metallic glasses (HE-BMGs), Ti20Hf20Cu20Ni20Be20 with a critical diameter of 2 mm, and Ti16.7Zr16.7Nb16.7Cu16.7Ni16.7Be16.7 with a critical diameter of 1.5 mm, can be fabricated by copper mold casting method. These newly developed HE-BMGs exhibited a high fracture strength over 2300 MPa. The glass forming ability and atomic size distribution characteristics of the HE-BMGs are discussed in detail. Moreover, a parameter δ′ was proposed to evaluate the atomic size distribution characteristics in different HEAs. It showed that this new parameter is closely related to the degree of lattice distortion and phase selection of high-entropy alloys. Adjusting the value of δ′ parameter by similar element substitution/addition would be beneficial for designing high entropy bulk metallic glasses.
Dynamics Analysis of Penetration against Pebble-Concrete Target
Authors: Yan Huan , Jin Lei , Gao Shiqiao , Xu Xiao , Li Zezhang , Fu He
Published: February 2022

The classical continuum mechanics theory cannot sufficiently describe the effect of pebbles on projectile, which leads to a large calculation error. In this paper, an orthogonal curvilinear coordinate system is constructed, which effectively describes and perfects the normal cavity expansion theory. A couple stress theory based on the normal cavity expansion is proposed in which not only the tangential movements but also the rotations of the concrete medium are considered. According to the high-speed impact of pebble concrete, combined with dynamic equations and the FE simulation, the theoretical and simulation results of pebble particles scale on warhead resistance are compared. It is shown that, the larger the scale of pebble particles, the stronger the effect of rotation on the resistant force applied on the warhead.
Intermediate-Temperature Tensile Behavior of a Hot-Rolled Mg-Li-Al-Cd-Zn Alloy
Authors: Zhang Lunyong , Huang Yongjiang , Wu Ming , Xu Chao , Ning Zhiliang , Cao Fuyang , Sun Jianfei
Published: February 2022

Developing light structure materials that work stably at elevated temperatures is a long-standing challenge for many application fields, particularly in the development of aerospace equipment. Zn/Cd alloying elements were prospected to improve the stability of the lightest Mg-Li based alloys; however, little is known about the intermediate-temperature mechanical properties of such alloys. The present work investigated the tensile behaviors of a cold-rolled Mg-Li-Al-Cd-Zn alloy in a temperature range of 30–150 °C. The results indicate that the alloy can host a tensile strength σUTS of 108~121 MPa, a yield strength σYP of 97~109 MPa and elongation εB of 14–15 % at 150 °C, dependent on the tensile direction. The mechanical properties intensively are modulated by temperature through the competition between work hardening and softening. Work hardening due to dislocation blocking by the precipitated MgLi2X phase dominated the deformation at low temperatures, while softening that resulted from dynamic recrystallization was the main effect at high temperatures. Correspondingly, a quasi-cleavage mechanism dominated the fracture at temperatures near room temperature, and microvoid coalescence worked at high temperatures above 100 °C. Our results offer a new experimental understanding of the elevated-temperature mechanical behaviors of Mg-Li alloys and will advance the development of new light magnesium alloys with high stability.
Properties and Microstructure of Na2CO3-Activated Binders Modified with Ca(OH)2 and Mg(OH)2
Authors: Xie Lilan , Liu Kaiwei
Published: February 2022

Delayed strength development and long setting times are the main disadvantageous properties of Na2CO3-activated slag cements. In this work, combined auxiliary activators of Ca(OH)2 and Mg(OH)2 were incorporated in one-part Na2CO3-activated slag binders to accelerate the kinetics of alkali activation. The properties and microstructure evolution were investigated to clarify the reaction mechanism. The results showed that the additions of auxiliary activators promoted the hardening of the pastes within 2 h. The 28 days compressive strengths were in the range of 39.5–45.5 MPa, rendering the binders practical cementitious materials in general construction applications. Ca(OH)2 was more effective than Mg(OH)2 in accelerating the kinetics of alkali activation. The dissolution of Ca(OH)2 released more OH− and Ca2+ ions in the aqueous phase to increase alkalinity in the aqueous phase and promote the formation of the main binding gel phase of calcium-aluminosilicate hydrate (C-A-S-H). An increase in the Ca(OH)2/Mg(OH)2 ratios increased autogenous shrinkage and decreased drying shrinkage of the binders. The formation of a compact pore structure restricted the water evaporation from the binders during the drying procedure.
Characterization of the Interface between Aluminum and Iron in Co-Extruded Semi-Finished Products
Authors: Thürer Susanne Elisabeth , Peters Kai , Heidenblut Torsten , Heimes Norman , Peddinghaus Julius , Nürnberger Florian , Behrens Bernd-Arno , Maier Hans Jürgen , Klose Christian
Published: February 2022

Within the framework of the Collaborative Research Center 1153, we investigated novel process chains for the production of bulk components with different metals as joining partners. In the present study, the co-extrusion of coaxially reinforced hollow profiles was employed to manufacture semi-finished products for a subsequent die-forging process, which was then used for the manufacture of hybrid bearing bushings. The hybrid hollow profiles, made of the aluminum alloy EN AW-6082 paired with either the case-hardening steel 20MnCr5, the stainless steel X5CrNi18-10, or the rolling bearing steel 100Cr6, were produced by Lateral Angular Co-Extrusion. Push-out tests on hybrid hollow sections over the entire sample cross-section showed shear strengths of 44 MPa ± 8 MPa (100Cr6) up to 63 MPa ± 5 MPa (X5CrNi18-10). In particular, the influence of force and form closure on the joint zone could be determined using specimen segments tested in shear compression. Locally, shear strengths of up to 131 MPa (X5CrNi18-10) were demonstrated in the shear compression test. From these samples, lamellae for microstructural analysis were prepared with a Focused Ion Beam. Detailed analyses showed that for all material combinations, a material bond in the form of an ultra-thin intermetallic phase seam with a thickness of up to 50 nm could be established.