bluuebunny/crossref_metadata_2025 huggingface dataset:
Dominance-submissiveness cues modulate pain threshold for mechanical pressure
Authors: Ivanec Dragutin , Stanke Koraljka Modić , Tomić Ivan , Matijaš Sanja
Published: November 2022

Acute pain sensation is an inherently negative but adaptive experience; however, research on pain sensitivity shows that simple contextual cues can effectively attenuate the pain. In this study, we sought to investigate how dominance cues, manipulated as vertical spatial (i.e., height) distance between participants and experimenter, affect participants’ pain sensitivity. Positioning participants in a spatially higher position relative to the experimenter was aimed to induce a feeling of dominance in participants. Conversely, a feeling of submissiveness was induced by placing the experimenter in a spatially higher position. In addition, we examined the role of dominance cues with respect to participants’ and experimenters’ gender. Two separate studies were conducted—Study 1 with a male experimenter measuring pain threshold in female and male participants ( N = 137), and Study 2 with a female experimenter conducting pain measurement in a new sample of female and male participants ( N = 122). The results of both studies demonstrated that participants in a dominant position reported a higher pain threshold relative to participants in a submissive position. Male participants had a higher pain threshold in both studies; however, Study 1 revealed a significant interaction of dominance manipulation and participant’s gender, with the effect of dominance cues being larger in men.
Precision and accuracy of measuring finger motion with a depth camera: a cross-sectional study of healthy participants
Authors: Lv Lulu , Yang Jiantao , Gu Fanbin , Fan Jingyuan , Zhu Qingtang , Liu Xiaolin
Published: November 2022

The purpose of this cross-sectional study was to determine the precision and accuracy of the measurement of finger motion with a depth camera. Fifty-five healthy adult hands were included. Measurements were done with a depth camera and compared with traditional manual goniometer measurements. Repeated measuring showed that the overall repeatability and reproducibility of extension measured with the depth camera were within 3° and 4° and that of flexion were within 13° and 14°. Compared with traditional manual goniometry, biases of extension of all finger joints and flexion of metacarpophalangeal joints were less than 5°, and the average bias of flexion of proximal and distal interphalangeal joints was 29°. We conclude that the measurement of finger extension and flexion of the metacarpophalangeal joints with a depth camera was reliable, but improvement is required in the precision and accuracy of interphalangeal joint flexion.
Similar Clinical Outcome in Locking and Conventional Plate Osteosynthesis for the Treatment of AO 44-B2 Ankle Fractures
Authors: Schagemann Jan C. , Neumann Hanjo , Schäfers Jana , Paech Andreas , Wendlandt Robert , Oheim Ralf , Schulz Arndt Peter
Published: November 2022

Introduction

Biomechanical studies have proved that locking plates have better primary stability besides versatility regarding fracture pattern while reducing bone contact and bridging the gap, whereas conventional nonlocking plates (plus lag screw) depend on bone-plate compression. The clinical benefit of locking plates over nonlocking plates remains unanswered, however. Therefore, this retrospective cohort study was set up to test the hypothesis that the use of locking plates for unstable ankle fractures will result in fewer re-displacements, superior bony healing, and functional and clinical outcomes better than observed in the nonlocking cohort.

Methods

Bimalleolar ankle fractures (AO 44-B2) without syndesmotic injury treated with either a locking or a nonlocking plate were included. Groups were compared for complications, bone healing, secondary dislocation, progressions of osteoarthritis, and clinical outcome using patient-reported outcome measures.

Results

Data revealed no clinical outcome differences (Olerud-Molander Ankle Score: nonlocking 88.2 ± 14.4, locking 88.8 ± 12.3, P = .69, robust two 1-sided test for equality (RTOST): P = .03; American Orthopaedic Foot and Ankle Score: nonlocking 91.2 ± 12.9, locking 91.8 ± 11.3, P = .96, RTOST: P = .04). Nevertheless, a significant postoperative progression of osteoarthritis was detected in both groups (P = .04). This was independent of implant (P = .16). Although difference was not significant, locking plates were preferred in older (P = .78) and sicker patients (P = .63) and in cases with severer osteoarthritis (P = .16), and were associated with a higher complication rate (P = .42) and secondary dislocation (nonlocking 9.4%, locking 18.2%; P = .42). Re-displacement, however, was not a compelling reason for revision.

Conclusions

The present study shows statistically significant equality of both types of implants. Contrary to our expectation, locking plates seemed to be associated with a higher risk for re-displacement. Overall, the use of either locking or nonlocking plates for unstable AO 44-B2 fractures is safe and successful despite significant progression of osteoarthritis.

Level of Evidence:

III, Retrospective observational cohort study
Effect of Teaching Metacognitive Reading Strategies on Reading Comprehension of Engineering Students
Authors: khellab Faisal , Demirel Özcan , Mohammadzadeh Behbood
Published: November 2022

This experimental research investigates the impact of teaching metacognitive reading strategies on the reading comprehension of engineering students in the English for Science and Technology(EST) context. This research is the first empirical study of its kind in Libyan English as a Foreign Language (EFL/EST) context. The study utilizes the Survey of Reading Strategies (SORS) and a reading comprehension achievement test extracted from ‘Oxford English for Computing’ by Boechner and Brown (instruction manual). The treatment incorporates the explicit teaching of metacognitive strategies to the participants in the experimental group via the Cognitive Academic Language Learning Approach (CALLA) model. Paired-samples t-test results signify a considerable treatment effect among the experimental group. In conclusion, the findings support previous research indicating that explicit instruction effectively improves Libyan EST students’ metacognitive awareness and produces statistically significant gains in reading comprehension.
Inpatient Care Service Experience Among Adult Patients Admitted to Arba Minch General Hospital, Southern Ethiopia: Institution-Based Qualitative Study
Authors: Sabo Kebede Gemeda , Mare Kusse Urmale , Berhe Hailemariam , Berhe Haftu
Published: November 2022

Acknowledging patients' experience with the care delivered in healthcare settings is crucial in ensuring the quality of healthcare service delivery. In Ethiopia, qualitative evidence of patients’ experience with inpatient care services is limited. This study aimed to explore the experience of inpatient care service among adult patients admitted to Arba Minch General hospital, Southern Ethiopia from April 05-28, 2020. An institution-based qualitative approach was carried out among adult patients discharged from the study hospital. Thirty-one in-depth interviews using a semi-structured interview guide were conducted and audio-recorded data were transcribed verbatim and translated into English. Data were coded, sorted, and themes were developed manually based on the thematic analysis. This study showed that kindness, respecting appointments, and treatment outcomes were the positive experiences highlighted by study participants. Participants reported a lack of drinking water, unpleasant toilet hygiene, lack of bedsheets, and absence of drugs as negative experiences. Therefore, the hospital administration should work on improving the problems mentioned by the participants of this study.
Eosinophils protect against pulmonary hypertension through 14-HDHA and 17-HDHA
Authors: Shu Ting , Zhang Jiawei , Zhou Yitian , Chen Zhihua , Li Jinqiu , Tang Qihao , Lei Wenqi , Xing Yanjiang , Wang Jing , Wang Chen
Published: November 2022

Background

Pulmonary hypertension (PH) is a life-threatening disease featuring pulmonary vessel remodelling and perivascular inflammation. The effect, if any, of eosinophils (EOS) on the development of PH remains unclear.

Methods

EOS infiltration and chemotaxis were investigated in peripheral blood and lung tissues from pulmonary arterial hypertension (PAH) patients without allergic history and from sugen/hypoxia-induced PH mice. The role of EOS deficiency in PH development was investigated usingGATA1-deletion (ΔdblGATA) mice and anti-interleukin 5 antibody-treated mice and rats. Ultra-high-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) was conducted to identify the critical oxylipin molecule(s) produced by EOS. Culture supernatants and lysates of EOS were collected to explore the mechanisms in co-culture cell experiments.

Results

There was a lower percentage of EOS in peripheral blood but higher infiltration in lung tissues from PAH patients and PH mice. PAH/PH lungs showed increased EOS-related chemokine expression, mainly C-C motif chemokine ligand 11 derived from adventitial fibroblasts. EOS deficiency aggravated PH in rodents, accompanied by increased neutrophil and monocyte/macrophage infiltration. EOS highly expressed arachidonate 15-lipoxygenase (ALOX15). 14-hydroxy docosahexaenoic acid (14-HDHA) and 17-HDHA were critical downstream oxylipins produced by EOS, which showed anti-inflammatory effects on recruitment of neutrophils and monocytes/macrophages through N-formyl peptide receptor 2. They also repressed pulmonary artery smooth muscle cell (PASMC) proliferation by activating peroxisome proliferator-activated receptor γ and blunting Stat3 phosphorylation.

Conclusions

In PH development without external stimuli, peripheral blood exhibits a low EOS level. EOS play a protective role by suppressing perivascular inflammation and maintaining PASMC homeostasisvia14/17-HDHA.
Group-based pulmonary telerehabilitation is feasible, safe, beneficial and well-received in patients who have been hospitalised with COVID-19
Authors: Simpson Andrew J. , Green Angela , Nettleton Marion , Hyde Lucy , Shepherdson Joanne , Killingback Clare , Marshall Phil , Crooks Michael G.
Published: November 2022

Introduction

Coronavirus disease 2019 (COVID-19) has caused worldwide mass hospitalisation. The need for multidisciplinary post-hospitalisation rehabilitation is becoming increasingly apparent, and telerehabilitation has been endorsed. The aim of study was to investigate the feasibility and efficacy of pulmonary telerehabilitation for COVID-19 survivors.

Methods

This was a single-centre, mixed-methods, fast-track (wait-list), randomised controlled trial of telerehabilitation for patients who had been hospitalised with COVID-19. 40 patients discharged from two university teaching hospitals in the north of England were recruited. Telerehabilitation consisted of 12 exercise classes, six education events and opportunity for peer support. Patients commenced telerehabilitation 14 days after randomisation in the fast-track group and 56 days after randomisation in the wait-list group.

Outcome measures and results

Descriptive and statistical improvements were noted in several clinical outcome measures. Exercise capacity increased from a median (interquartile range) 20 (14–24) sit-to-stand repetitions in 1 min at baseline to 25 (24–30) post-telerehabilitation. Breathlessness rated using the Medical Research Council dyspnoea scale changed from 3.5 (3–4) at baseline to 2 (1.5–3) post-telerehabilitation, with additional favourable outcomes noted in respiratory symptoms measured using numerical rating scales and visual analogue scales (VAS). Quality of life measured using the EuroQol VAS improved from 55 (60–70) units at baseline to 70 (55–80) units following telerehabilitation. Improvements in fatigue (modified Functional Assessment of Chronic Illness Therapy: Fatigue) and mood (Hospital Anxiety and Depression Scale – Depression) were also observed. Natural recovery was observed in the wait-list group prior to receiving telerehabilitation; however, improvements were accelerated by early telerehabilitation in the fast-track group.

Conclusions

We have shown that group-based telerehabilitation is feasible, safe, beneficial and well-received in this population.
The risk of post-operative pulmonary complications in lung resection candidates with normal forced expiratory volume in 1 s and diffusing capacity of the lung for carbon monoxide: a prospective multicentre study
Authors: Cundrle Ivan , Merta Zdenek , Bratova Monika , Homolka Pavel , Mitas Ladislav , Sramek Vladimir , Svoboda Michal , Chovanec Zdenek , Chobola Milos , Olson Lyle J. , Brat Kristian
Published: November 2022

Introduction

According to the guidelines for preoperative assessment of lung resection candidates, patients with normal forced expiratory volume in 1 s (FEV1) and diffusing capacity of the lung for carbon monoxide (DLCO) are at low risk for post-operative pulmonary complications (PPC). However, PPC affect hospital length of stay and related healthcare costs. We aimed to assess risk of PPC for lung resection candidates with normal FEV1andDLCO(>80% predicted) and identify factors associated with PPC.

Methods

398 patients were prospectively studied at two centres between 2017 and 2021. PPC were recorded from the first 30 post-operative days. Subgroups of patients with and without PPC were compared and factors with significant difference were analysed by uni- and multivariate logistic regression.

Results

188 subjects had normal FEV1andDLCO. Of these, 17 patients (9%) developed PPC. Patients with PPC had significantly lower pressure of end-tidal carbon dioxide (PETCO2) at rest (27.7versus29.9; p=0.033) and higher ventilatory efficiency (V′E/V′CO2) slope (31.1versus28; p=0.016) compared to those without PPC. Multivariate models showed association between restingPETCO2(OR 0.872; p=0.035) andV′E/V′CO2slope (OR 1.116; p=0.03) and PPC. In both models, thoracotomy was strongly associated with PPC (OR 6.419; p=0.005 and OR 5.884; p=0.007, respectively). Peak oxygen consumption failed to predict PPC (p=0.917).

Conclusions

RestingPETCO2adds incremental information for risk prediction of PPC in patients with normal FEV1andDLCO. We propose restingPETCO2be an additional parameter to FEV1andDLCOfor preoperative risk stratification.
Highlights from the Respiratory Failure and Mechanical Ventilation 2022 Conference
Authors: Viegas Pedro , Ageno Elisa , Corsi Gabriele , Tagariello Federico , Razakamanantsoa Léa , Vilde Rudolfs , Ribeiro Carla , Heunks Leo , Patout Maxime , Fisser Christoph
Published: November 2022

The Respiratory Intensive Care Assembly of the European Respiratory Society gathered in Berlin to organise the second Respiratory Failure and Mechanical Ventilation Conference in June 2022. The conference covered several key points of acute and chronic respiratory failure in adults. During the 3-day conference, ventilatory strategies, patient selection, diagnostic approaches, treatment and health-related quality of life topics were addressed by a panel of international experts. Lectures delivered during the event have been summarised by Early Career Members of the Assembly and take-home messages highlighted.
Implementation of non-pharmacological interventions for the treatment of hypertension in primary care: a narrative review of effectiveness, cost-effectiveness, barriers, and facilitators
Authors: Dhungana Raja Ram , Pedisic Zeljko , de Courten Maximilian
Published: November 2022

Background

The current guidelines for the prevention, detection, evaluation, and management of hypertension recommend six types of non-pharmacological interventions: alcohol reduction, salt intake reduction, increased potassium intake, physical activity, weight loss, and heart-healthy diets. However, the non-pharmacological interventions are still not widely used in primary care. In this paper, we, therefore, reviewed and summarised the evidence on the effectiveness, cost-effectiveness, barriers, and facilitators of non-pharmacological interventions for the treatment of hypertension in primary care.

Methods

A thorough literature search was conducted in Embase, Google Scholar, and PubMed databases, to identify the most recent reviews or, in their absence, primary studies on alcohol reduction, salt intake reduction, potassium supplementation, physical activity, weight reduction, heart-healthy diets, and other non-pharmacological interventions for the treatment of hypertension in primary care.

Results

Alcohol reduction is a non-pharmacological intervention for the treatment of hypertension in primary care with proven effectiveness, feasibility, and acceptability. Interventions for sodium intake reduction, physical activity, and weight reduction are effective but there is insufficient evidence regarding their feasibility and acceptability in primary care settings. Evidence on the effectiveness of potassium intake and heart-healthy diets is limited and inconsistent. There is a lack of evidence on the cost-effectiveness of non-pharmacological interventions in the treatment of hypertension. The most common barriers to deliver such interventions related to healthcare providers include a lack of time, knowledge, self-confidence, resources, clear guidelines, and financial incentives. The most common barriers related to patients include a lack of motivation and educational resources. Less evidence is available on facilitators of implementing non-pharmacological interventions in primary care. Besides, facilitators differed by different types of interventions.

Conclusions

Available evidence suggests that more pragmatic, clinically feasible, and logistically simple interventions are required for sodium intake reduction, physical activity, and weight reduction in primary care settings. Future studies should provide further evidence on the effectiveness of weight control, potassium intake, and heart-healthy diets. More research is also needed on cost-effectiveness and facilitators of all types of effective non-pharmacological interventions for the treatment of hypertension in primary care.
Retraction Note: Effects of Panax notoginseng saponins on severe acute pancreatitis through the regulation of mTOR/Akt and caspase-3 signaling pathway by upregulating miR-181b expression in rats
Authors: Liu Ming-wei , Wei Rui , Su Mei-xian , Li Hui , Fang Tian-wen , Zhang Wei
Published: November 2022

This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1186/s12906-018-2118-8.
Bladder nephrogenic adenoma as a complication of surgical correction of megaureter
Authors: Rostyslav Nakonechnyy , Andrii Nakonechnyi
Published: November 2022

Background

Bladder nephrogenic adenoma (BNA) is a rare benign proliferative pathology of its mucosa. The etiopathogenesis of the disease remains uncertain, and the treatment is still challenging.

Case presentation

In this article, we present a clinical case of bladder nephrogenic adenoma in a 6-year-old boy. Clinical symptoms of the disease appeared 3 years after surgical treatment of obstructive megaureter. Histopathological and immunohistochemical examination of glandular polyp biopsies allowed excluding the tumor process and making a diagnosis.

Conclusion

Nephrogenic adenomas demonstrate a variety of morphologic patterns that may occasionally be confused with malignant processes. We described the endoscopic characteristics of BNA and characterized its histological and immunohistochemical features in a boy after ureteroneocystostomy.
ARTIGO DE REVISÃO O uso do guaraná (Paulinia cupana) como suplemento dietético antienvelhecimento: uma revisão sistemática
Authors: Oliveira Keciany Alves de , Cabral Marília Magahães , Barroso Raquel Pompeu de Montier , Freitas Paula Alexandre de , Lima Victor Vincent Morais de , Macêdo Levi Magalhães Gurgel , Dantas Ana Cecília Pereira , Oliveira Ariclécio Cunha de
Published: November 2022

Objetivo: o presente estudo busca avaliar se o guaraná poderia ser utilizado no antienvelhecimento. Métodos: foi realizada uma revisão sistemática de acordo com as normas do PRISMA. As bases de dados utilizadas foram Scielo e Medline (PUBMED). Foram incluídos artigos originais publicados entre 2016 e 2021 que avaliem os efeitos da suplementação do guaraná sobre os marcadores do envelhecimento. Foi realizada a avaliação de risco de viés pelo SYRCLE. Oito publicações foram incluídas nesta revisão após a análise dos critérios de inclusão e exclusão. Resultados: o guaraná aumentou a expectativa de vida e reduziu os marcadores de envelhecimento pelo seu efeito antioxidante. O guaraná preveniu o ganho de peso, a resistência à insulina, a desregulação de adipocinas, estimulou a biogênese mitocondrial e apresentou atividade anti-inflamatória. Assim, a ativação do tecido adiposo parece ser um dos mecanismos de ação envolvidos na suplementação de guaraná como antienvelhecimento. Contudo, a maioria dos estudos tiveram alto risco de viés, quanto ao uso do guaraná no retardo das alterações associadas ao envelhecimento. Conclusão: desta forma, para que se tenha uma recomendação da aplicabilidade do guaraná, faz-se necessária a realização de mais estudos com melhor qualidade metodológica.
Produção e uso de filtros de água com carvão ativado derivado de matérias sustentáveis
Authors: Costa Hudson Pimentel , Santos Rogério Nunes dos , Ribeiro Livia Paulia Dias , Pinto Olienaide Ribeiro de Oliveira , Pinto Ciro De Miranda , Costa Danielle Rabelo , Alcócer Juan Carlos Alvarado
Published: November 2022

Objective: to evaluate the efficiency of water treatment filters using activated carbon from different sources of biomass residue. Methods: this is a descriptive experimental study of a quantitative nature carried out at the Centro Universitário Católica de Quixadá, Ceará-Brazil, during the period from January to June 2018. Activated carbon filters were prepared, and subsequently, their efficiency in water treatment was evaluated. Wood waste, green coconut husk, cashew nut shell, and bamboo stem were used as a source of raw material. The water treatment filter was assembled using the column chromatography method by adding sand and cotton as other filter media. Physicochemical parameters were used to evaluate the efficiency of the built filters. Results: principal component analysis selected two water quality components, explaining 80.081% of the total variance. The cophenetic correlation coefficient of r=0.9572 indicates that the estimated dendrogram was good, considering the water quality parameters. Among the filters, bamboo showed the best response among the filters tested, being responsible for the reduction of several factors such as color, turbidity, total hardness, and sodium. Conclusion: activated carbon filters derived from discarded wood and cashew nut shells had little influence on improving water quality compared to the control sample
Non-surgical methods of pain treatment improving the quality of life of patients with endometriosis
Authors: Golemo Jagna , Gryc Anna , Nowińska Aleksandra , Grudzień Monika , Świdziński Rafał
Published: November 2022

Introduction : Endometriosis is a disease that currently affects 10-15% of women of reproductive age worldwide. The main problem of female patients, in addition to infertility, is pain, which varies greatly, significantly reduces the quality of life and affects family, social, sexual and professional life. Pharmacological treatment, which is applied both after the excision of the lesions and in patients who were not eligible for surgery, is an important element of pain therapy. There are also other methods, such as appropriate diet change, supplementation, acupuncture, electrotherapy, which are partially effective.
Method : review of the recent literature based on PubMEd ,Google scholar research based on the following keywords : endometriosis treatment, hormonal treatment of endometriosis, quality of life of patients with endometriosis
Purpose of work : Comparison of the mode of action and effectiveness of individual non-surgical methods of treating pain in patients with endometriosis.
Trabalho e Educação: Um Estudo de Caso com Professores de Escolas Rurais
Authors: Marinho Paulo Roberto Ribeiro , Schmidt Maria Luiza Gava , Vasconcelos Mário Sérgio
Published: November 2022

O presente artigo propõe analisar o contexto de trabalho dos professores de duas escolas rurais do interior do estado de São Paulo, com o intuito de demonstrar que o ambiente de trabalho pode estar relacionado aos riscos de adoecimento dos professores, considerando a perspectiva de saúde do trabalhador. Trata-se de um estudo de caso exploratório descritivo com enfoque quantitativo, que contou com a participação de 20 professores das duas escolas rurais. Os instrumentos de coleta de dados foram Questionário Sociodemográfico e Escala de Avaliação do Contexto de Trabalho (EACT), que abordam aspectos da organização, das condições de trabalho e das relações socioprofissionais. Os resultados apontaram para o nível crítico nos três fatores avaliados na escola "B", que indicaram aspectos tais como o número insuficiente de pessoas para realizar as tarefas, as tarefas repetitivas, entre outros. Na escola "A", o fator Organização do Trabalho foi avaliado de forma negativa, em itens como a falta de tempo para realizar a pausa de descanso e a rigidez das normas das tarefas. Esses aspectos revelam estado de preocupação nas escolas e merecem medidas de intervenção nesse ambiente a fim de minimizar riscos à saúde dos professores que atuam no contexto de escola rural.
Encontro de Combate e Prevenção ao Suicídio: Relato de Experiência em uma Universidade Pública
Authors: Peluso Marcelo Leonel , Pereira Arthur Teixeira , Leopoldino Letícia Costa , Leme Vanessa Barbosa Romera
Published: November 2022

Este estudo tem por objetivo apresentar um relato de experiência do projeto Encontro de Combate e Prevenção ao Suicídio (ECPS), de iniciativa discente, cuja proposta é organizar, anualmente, um evento aberto ao público com palestras e atividades acerca do suicídio. Os encontros são organizados na Universidade do Estado do Rio de Janeiro (UERJ) e, atualmente, conta-se com três edições, tendo cada uma abordado um recorte temático diferente sobre o suicídio. A fim de contribuir cientificamente com propostas de prevenção ao suicídio, todo encontro tem como procedimento o envio de dois formulários. O pré-evento possui a finalidade de investigar o interesse dos participantes e o pós-evento busca verificar seu impacto em relação à percepção dos ouvintes acerca das atividades e quais temas são considerados relevantes para o debate. Os formulários foram aplicados a 1053 respondentes. Os resultados indicaram que houve uma boa adesão ao projeto em virtude da quantidade de inscritos e do interesse em participar de outras edições do encontro. Por meio dos dados coletados e da narrativa dos organizadores, no que diz respeito às experiências e desafios, viabiliza-se a elaboração de projetos futuros que tenham como foco a prevenção do suicídio.
Preditores de Barreiras à Criatividade de Estudantes de Engenharia
Authors: Pereira-Guizzo Camila De Sousa , Gomes Marcus Vinicius Mendes , Nogueira Tarso Barretto Rodrigues , Murta Sheila Giardini
Published: November 2022

Na formação de engenheiros, a criatividade é valorizada por estar relacionada com inovação, mas há muitos desafios para serem enfrentados a fim de encorajá-la nesse contexto. Buscando oferecer condições para o desenvolvimento da criatividade no ensino superior, a literatura investiga a existência de fatores pessoais e ambientais que podem facilitar ou inibir a expressão criativa dos universitários. O objetivo foi identificar preditores de barreiras à criatividade de estudantes de engenharia, considerando variáveis pessoais e acadêmicas. Participaram 374 universitários, que responderam ao Questionário para Caracterização da Amostra e ao Inventário de Barreiras à Criatividade Pessoal. Regressão logística múltipla foi usada para tratamento dos dados. A variável resposta (se concordam ou não com fatores que refletem barreiras à criatividade) foi explicada levando em consideração um conjunto de variáveis preditoras (idade, gênero, curso de engenharia, período de curso e se trabalha). Os principais resultados sugerem que as variáveis gênero feminino e primeiro ano do curso foram preditoras para a barreira Inibição/Timidez; e as variáveis primeiro e segundo ano do curso foram preditoras para a barreira Repressão Social. Discutiu-se a importância desses resultados na ampliação de recursos pessoais e no fortalecimento de uma cultura institucional voltada para a valorização e o desenvolvimento da criatividade.
"Médico Disse que Era Só Psicológico": Analisando o Lugar da Psicologia no Campo da Saúde
Authors: Farias Isabela Cedro , Alves Samara Vasconcelos , Vieira Camilla Araújo Lopes , Furtado Luis Achilles Rodrigues , Lima Aluísio Ferreira de
Published: November 2022

As clínicas-escola de Psicologia vêm ocupando um lugar de centralidade nas regiões onde estão inseridas, pois acabam por dar suporte aos casos de "saúde mental" das redes de assistência social, educacional e, sobretudo, da saúde. Nesse sentido, nosso objetivo foi analisar os encaminhamentos da Atenção Primária à Saúde (APS) do município de Sobral-CE ao serviço-escola de Psicologia da Universidade Federal do Ceará (UFC). O estudo foi qualitativo e documental, uma vez que 293 prontuários, oriundos da APS, foram a fonte de pesquisa. Os dados foram analisados por meio da Análise de Discurso Crítica e a reflexão tomou como referência saber quem eram os profissionais que encaminhavam, o que "diziam" ao encaminhar e quais as sugestões de tratamentos consideravam mais adequadas. Constatamos que os psicólogos são os profissionais que mais encaminham ao serviço. Nos encaminhamentos feitos pelos médicos, percebemos a dificuldade de lidar e mesmo reconhecer o que não é palpável, com o que é "só psicológico". Por fim, consideramos que o que não pode ocorrer na atenção básica em saúde é a própria Psicologia, no entanto, as grandes filas de espera e os encaminhamentos massivos às clínicas-escola de Psicologia deflagrem o reconhecimento da importância da clínica, do atendimento individual.
Repercussões do Acesso às Redes Sociais em Pessoas com Diagnóstico de Anorexia Nervosa
Authors: Moraes Raquel Borges de , Santos Manoel Antônio dos , Leonidas Carolina
Published: November 2022

A exposição prolongada às mídias digitais tem sido associada ao desenvolvimento de mudanças no comportamento alimentar, mediante a internalização de padrões de magreza idealizada. Este estudo teve por objetivo investigar a percepção de pessoas com diagnóstico de transtornos alimentares acerca da influência do acesso às redes sociais virtuais sobre a precipitação e/ou manutenção de seus sintomas. Participaram seis mulheres e um homem, com diagnóstico de anorexia nervosa, que se encontravam em tratamento em um serviço especializado de um hospital universitário do interior paulista. Utilizou-se um roteiro de entrevista semiestruturada aplicada individualmente e audiogravada. Os dados foram transcritos e organizados em três categorias temáticas: Reverberações emocionais do acesso indiscriminado aos conteúdos online;Tomada de consciência acerca da influência perniciosa da mídia; Internet como fonte privilegiada de acesso à informação de qualidade duvidosa. Analisados com o amparo da literatura específica da área, os resultados indicaram que as redes sociais estimulam a busca obsessiva de um corpo idealizado, associando-o com a obtenção de felicidade e satisfação pessoal sob a égide do individualismo. Espera-se que os achados incentivem um olhar crítico acerca dos conteúdos disseminados indiscriminadamente no universo virtual.
Entre a Dor e a Alegria: Repercussões Subjetivas no Ser Palhaço(a)
Authors: Silva João Paulo Nogueira da , Silva Carolina Ventura , Brandão Fernando Mateus Viegas , Pedroso Janari Da Silva
Published: November 2022

Investigou-se como a dor e a alegria podem influenciar a construção do ser palhaço(a) com o objetivo de compreender melhor a construção da sua subjetividade. Foram realizadas entrevistas com dez palhaços(as). Utilizou-se como método a análise de conteúdo e o software NVivo® para sistematizar as informações presentes nos discursos dos(as) participantes em doze categorias, agrupadas em dois eixos temáticos e analisadas a partir de sua pertinência na construção do entendimento de ser palhaço(a). Os resultados indicaram que a dor diante de perdas afetivas no processo de ser palhaço(a) passa pela transformação do trágico à comicidade, não para minimizá-la, mas para lidar com a finitude humana por meio da ética, poética e estética de afirmação da vida. A transgressão da palhaçaria permite superar dificuldades e transformá-las criativamente em riso. Conclui-se que o ser palhaço(a) torna-se a vitrine das condições humanas apresentadas por meio do cômico, do trágico, do ridículo, do perder, do político, do rústico e do ser-no-mundo.
Loucos por Ler: Oficinas Expressivas em um Centro de Atenção Psicossocial Infantojuvenil
Authors: D'Urso Lourdes Aparecida , Jurdi Andréa Perosa Saigh
Published: November 2022

O objetivo deste artigo é discutir os significados da leitura e escrita para adolescentes de um Centro de Atenção Psicossocial Infantojuvenil do município de São Paulo, por meio do acompanhamento de um trabalho com oficinas expressivas e seus desdobramentos. Trata-se de uma pesquisa-intervenção com uso de diário de campo. A leitura e a linguagem escrita foram entendidas como objetos culturais, promotores da interação social e capazes de auxiliar na superação de crises, conforme pesquisas da antropóloga Michèle Petit. Nos grupos, eram realizados jogos, leitura de textos de diferentes gêneros discursivos e atividades de escrita, além de visitas a equipamentos culturais. A análise dos dados inspirou-se na obra de Mikhail Bakhtin. O estudo permitiu compreender aspectos singulares do ato de ler para cada participante e possibilitou ainda produções escritas mais significativas e com função social. Um desdobramento do estudo foi a realização de um novo ciclo de oficinas, que expôs as produções dos usuários no espaço de convivência do serviço.
A pyridinesulfonamide derivative FD268 suppresses cell proliferation and induces apoptosis via inhibiting PI3K pathway in acute myeloid leukemia
Authors: Chen Yi , Wu Tianze , Yang Chengbin , Lu Mingzhu , Chen Zhenxia , Deng Mingli , Jia Yu , Yang Yongtai , Liu Xiaofeng , Wang Hongyan , Ling Yun , Lu Lei , Zhou Yaming
Published: November 2022

Aberration of PI3K signaling pathway has been confirmed to be associated with several hematological malignancies including acute myeloid leukemia (AML). FD268, a pyridinesulfonamide derivative characterized by the conjugation of 7-azaindole group, is a newly identified PI3K inhibitor showing high potent enzyme activity at nanomole concentration. In this study, we demonstrated that FD268 dose-dependently inhibits survival of AML cells with the efficacy superior to that of PI-103 (pan-PI3K inhibitor) and CAL-101 (selective PI3Kδ inhibitor) in the tested HL-60, MOLM-16, Mv-4-11, EOL-1 and KG-1 cell lines. Further mechanistic studies focused on HL-60 revealed that FD268 significantly inhibits the PI3K/Akt/mTOR signaling pathway, promotes the activation of pro-apoptotic protein Bad and downregulates the expression of anti-apoptotic protein Mcl-1, thus suppressing the cell proliferation and inducing caspase-3-dependent apoptosis. The bioinformatics analysis of the transcriptome sequencing data also indicated a potential involvement of the PI3K/Akt/mTOR pathway. These studies indicated that FD268 possesses high potent activity toward AML cells via inhibition of PI3K/Akt/mTOR signaling pathway, which sheds some light on the pyridinesulfonamide scaffold for further optimization and investigation.
Geochemical features of strontium accumulation and migration in the peats of the Lviv Region
Authors: Yakovenko Myroslava
Published: November 2022

The article is devoted to the study of geochemical characteristics of the distribution, accumulation and migration of Strontium in the lowland peats of the Lviv region, both laterally and vertically, and to identify the main factors influencing the formation of its concentrations. A significant uneven distribution of concentration, high dispersion and variability (coefficient of variation – 116.61, standard deviation – 564.11) of Sr in peats within deposits, districts and regions both with depth and area of distribution and high content indicators were established Sr relative to clarks of the lithosphere, soils, plant ash (CC relative to the lithosphere = 1.42; CC relative to soil clarks = 1.94; Сs relative to background values in the soils of Ukraine = 4.56; CK relative to clarks of terrestrial plants = 1.61). The content of Sr in the peat of the Lviv region ranges from 40–3190 mg/kg (average content 483.75 mg/kg, median content (background content) – 250 mg/kg), which is due to natural-climatic, geological, lithological, hydrogeochemical and anthropogenic factors. The features of the distribution and the degree of concentration of Sr in the peatlands of the Lvіv region are mainly influenced by the chemical-mineralogical-petrographic composition of the bedrocks of the wear area during their weathering; terrain, climatic, geomorphological, tectonic and hydrogeological conditions of the area, which determine the of the weathering processes of the rocks in the wear areas, the degree of transformation of terrigenous material in the weathering processes, the rate of accumulation of biomass and the rate of its decomposition; features of water and mineral nutrition of the peatland. High concentrations of Strontium in the peat of the Lviv region reflect the local regional processes of the concentration of the element in the mass of peat and may indicate the accumulation of Sr of both natural and anthropogenic origin in the upper layers of peat profiles.There is an enrichment of Sr in the upper intervals of deposits (0–1 m) of deposits in the northeastern part of the Lviv region (Malopoliska peat region) is observed.
Çukuriçi Höyük 4
Authors: Cveček Sabina
Published: November 2022

Çukuriçi Höyük 4. Household Economics in the Early Bronze Age Aegean is a pioneering interdisciplinary account of households and socio-political organization in Aegean prehistory, written by a socio-cultural anthropologist embedded in a team of prehistoric archaeologists. Sabina Cveček applies methods of historical anthropology to address key issues in discussing households and socio-political organization at the dawn of the Bronze Age Aegean and beyond. By navigating through the “dwelling perspective” at two prehistoric mound sites, namely Çukuriçi Höyük in western Anatolia (Turkey) and Platia Magoula Zarkou in Thessaly (Greece), Cveček scrutinizes the conflicting relations between metanarratives and site-based archaeological contexts, complemented by historical ethnographic accounts. This unique interdisciplinary contribution will appeal not only to specialists in Aegean prehistory and historical anthropologists, but also to scholars in the social sciences and humanities. It may inspire scholars to recognize the unparalleled value of archaeological materiality in addressing non-state imagined communities, alongside historical, ethnographic, and other written sources.
A sensitive, heart-cutting, two-dimensional liquid chromatography–tandem mass spectrometry method for the determination of mometasone furoate in human plasma: Application for a bioequivalence study in nasal spray formulations
Authors: Yang Leting , Yang Hongyi , Xie Huiru , Liu Hui , He Gangmin , Zhong Wenjing , Wang Ling
Published: November 2022

We developed and validated a sensitive, heart-cutting, two-dimensional liquid chromatography–tandem mass spectrometry (2D-LC‒MS/MS) method to determine the concentration of mometasone furoate in human plasma after nasal spray administration. Isotopically labeled mometasone furoate-13C,d6 was used as an internal standard (IS). Plasma samples were prepared using a solid-phase extraction (SPE) method. With this 2D-LC strategy, the analytes were trapped in the first dimension (1D) column, and only judiciously selected portions of the 1D effluent were transferred to the second dimension (2D) column for further separation to obtain high-resolution information. MS/MS quantification was performed in positive ionization mode via multiple-reaction monitoring (MRM). This analytical method was fully validated according to related regulatory guidance, and the results showed that the method is robust and sensitive enough for pharmacokinetic investigation of mometasone furoate with satisfactory linearity from 0.25 to 30 pg mL−1. This method was successfully applied to a bioequivalence (BE) study of mometasone furoate aqueous nasal sprays in healthy volunteers.
THE AUSTRALIAN LANDSCAPE OF ONLINE BACHELOR OF MUSIC COURSES PRE-COVID-19
Authors: Johnson Carol , Cheok Tiffany
Published: November 2022

The 2020 COVID-19 pandemic lockdowns and safety precautions resulted in many Australian higher education music courses being taught online. However, it has yet to be established to what extent were music courses offered online pre-pandemic in Australia. Therefore, the purpose of this paper is to identify online music program offerings at the bachelor level in Australia before COVID-19, identify similarities of pre-COVID online music class offerings in Australian universities, and provide implications and recommendations resulting from the findings. Using a document analyses method, findings indicated 20% of Australian bachelor of music (BMus) programs offered one or more core and/or elective music courses for music majors via online (asynchronous) learning prior to January 2020. This implies that during the online teaching that occurred due to 2020-2021 lockdowns in Australia, 80% of BMus programs in Australia were limited in preparedness for the required pivot to online teaching. The implications of online Australian BMus courses are addressed as are the opportunities for supporting music students' digital literacy through online music course offerings. Finally, the paper highlights recommendations for student preparedness, academic staff development, and areas for future research.
Bridging technical, ecological and social–economic knowledge in engineering design
Authors: Halbe Johannes , Adamowski Jan
Published: November 2022

Sustainable engineering design requires the joint consideration of technical, ecological, economic and social aspects in the provision of societal demands, such as water and energy supply. A growing number of concepts and methods for integrated assessment and sustainable design have been developed in recent decades and pose new challenges to the engineering profession. This paper proposes the use of system design concepts and methods to link engineering design to ecological and social–economic knowledge. This study expands the conventional functional analysis approach from systems engineering with a technical focus towards a more integrated perspective that allows for the joint consideration of technical, ecological and social–economic solutions in engineering design. Participatory systems thinking and system dynamics modelling are used for conceptual and preliminary system design by analysing the hierarchy and flows of functions to meet system requirements. The methodology consists of three steps: requirement analysis (step 1), functional organisation analysis (step 2) and functional flow analysis (step 3). An application of the methodology is provided using sustainable water management in Cyprus as an example. The results demonstrate the synergies and trade-offs between technical, ecological and social solutions in water management that provide important information for the subsequent detailed system design phase.
Effectiveness of Adjuvant Chemotherapy for elderly Patients with Triple-Negative Breast Cancer
Authors: Guo Qiusheng , Lan Tian , Lu Yunyan , Hu Zujian , Xu Haibin , Wang Xiaojia , Shao Xiying , Fu Xueyan
Published: November 2022

There is little evidence determining whether elderly patients (from 70 to 90 years old) with triple-negative breast cancer could benefit from adjuvant chemotherapy (AC).  This study explores the effect of AC in these population following surgery. A total of 4610 patients were identified in the Surveillance, Epidemiology, and End Results database (2010-2018). Multiple imputation by chained equations was performed to impute missing data. Inverse probability of treatment weighting (IPTW) was applied to reduce the selection bias. IPTW-adjusted Kaplan-Meiers survival analysis and Cox proportional hazards models were performed to compare breast cancer specific survival (BCSS) and overall survival (OS) in the two treatment groups. The patients were classified into the chemotherapy (n=1989) and the observation (n=2621) groups. The percentage of patients receiving AC versus observation increased significantly from 2010 to 2018 (estimated annual percentage change, 1.49%; 95%CI, 0.75-2.16%, p=0.002). The 5-year IPTW-adjusted rates of BCSS and OS in AC group were better than that in observation group (BCSS: 82.32% vs. 78.42%, p=0.010; OS: 75.54% vs. 64.65%, p<0.001). The patients could benefit from AC based on the results of IPTW-adjusted Cox proportional hazards regression analysis (BCSS: HR, 0.77, 95%CI, 0.62-0.94, p=0.012; OS: HR, 0.66, 95%CI, 0.57-0.78, p<0.001). AC was associated with a significant outcome benefit across the year at diagnosis, marital status, stage, lymph node, surgery, and radiation subgroups (all p<0.050). Patients with T1ab could not benefit from AC (p>0.050). In conclusion, we presented a BCSS and OS benefit from AC in elderly patients with triple-negative breast cancer (TNBC). AC remained a reasonable treatment approach in these specific patients. For the patients with T1ab, de-escalated treatment would be administrated with caution.
The effect of olfactory exposure on the heart rate of rabbits during transport
Authors: Anouck Haverbeke , Stefania Uccheddu , Dieter Everaert , Maya Lagae , Marie Lacoste , Heidi Arnouts , Adinda Sannen
Published: November 2022

Rabbits can experience stress during transport. This study explores the effects of Essential Oils (EOs) on the heart rate of rabbits during transport. Rabbits were submitted to 3 different treatments: no olfactory exposure to EOs (treatment 1, control); olfactory exposure to 30 drops of Lavandula angustifolia EO (treatment 2); and olfactory exposure to 30 drops of a blend of 5 EOs (treatment 3, Cananga odorata, Citrus aurantium, Cupressus sempervirens, Lavandula angustifolia, Litsea citrata EOs) in a randomized controlled crossover study design. Treatment 1 and Treatment 2 did not induce a significant change in rabbits’ heart rates, however, treatment 3 did induce a significant decrease in rabbits’ heart rates after transport. These results suggest that olfactory exposure to this blend of 5 EOs decreased the rabbit’s heart rate after transport. More research is needed to further evaluate the effects of olfactory enrichment with EOs in rabbits during transport.
Environmental Microsegregation: Urban Renewal and the Political Ecology of Health
Authors: Geiselhart Klaus , Spenger David
Published: November 2022

In recent years, multiple-burden maps were developed as a tool for assessing environmental health inequities in cities. Maps of this kind are particularly useful in identifying disadvantaged neighbourhoods. In the case of Erlangen (Germany), the historical development of poorer neighbourhoods may mean that their situation as regards environmental assets is relatively favourable. However, urban renewal often precipitates the redistribution of environmental “goods” and “bads” in such a way as to place a disproportionate burden on socio-economically deprived people and privilege the better-off. This type of environmental microsegregation occurs on a scale below that of neighbourhoods, which means that newly developed approaches in urban geography may fail to identify it. This article details the roots of these processes in changes in the structure of ownership and the respective administration of housing and considers possible methods for monitoring these tendencies.