bluuebunny/crossref_metadata_2025 huggingface dataset:
Effectiveness of Mifepristone plus Misoprostol and Misoprostol alone in Cervical Ripening and Induction of Labour in Postdated Pregnancy
Authors: Ghimire Asmita , Gurung Geeta , Ojha Bhuwan Prasad , Baral Josie
Published: May 2022

Aims: To compare the effectiveness of mifepristone plus misoprostol in pre-induction cervical ripening and induction of labour in uncomplicated post-dated primigravidae.
Methods: It is a hospital based prospective comparative study enrolling 50 uncomplicated post-dated pregnancies in each group to determine the efficacy and safety of mifepristone and misoprostol with misoprostol alone for induction. It was conducted in Institute of Medicine. Computer software SPSS 20 was used for processing and analysis of the data. Chi-square test and paired sample t-test was used.
Results: Comparing change in Bishops score among the two groups, no any statistically significant difference was seen. Sixty-six percent delivered vaginally in mifepristone group as compared to 42% in misoprostol group (p≤0.01). Rest delivered by caesarean section. No significant maternal side effects and complications were seen. Twenty-six percent in mifepristone group and 50% babies in misoprostol group developed fetal side effects (p=0.01).
Conclusions: Mifepristone and misoprostol both bring favourable change in the Bishop’s score. Regarding success rate and fetal complications mifepristone seems to be effective and safe.
Keywords: induction of labour, mifepristone, misoprostol, post-dated pregnancy
Past experience of women during childbirth in the periphery of western mountain region of Nepal during childbirth
Authors: Shah Rajiv , Baral Gehanath , Basnyat Subi , Shrestha Sharmila
Published: May 2022

Aims: To explore the past experience of women during childbirth in terms of respectful maternity on institutional deliveries in the region.
Methods: This is a cross sectional descriptive study among women during outdoor visit at Karnali Academy of Health Sciences in Jumla from April to August 2020. Data were analyzed in terms of seven components of respectful maternity care.
Results: The prevalence of obstetrics mistreatment was 78.5%. From 200 respondents, more than half had hospital delivery and one-fourth at local birthing center. Two-third of them perceives the care provided to them was proper and 85% opt to visit again to the same center in next pregnancy. Around 70-80% by ethnic group and at least three-fourth by the site of delivery have experienced at least one type of mistreatment.
Conclusions: Indicators of respectful maternity care are not satisfactory in the western mountainous region.
Keywords: institutional delivery, mistreatment, respectful maternity care
Exteriorization of uterus versus intrabdominal uterine closure at Caesarean delivery
Authors: Lamichhane Basant , Pokharel Shreesiya
Published: May 2022

Aims: To assess the intraoperative and post-operative complications of exteriorization repair with intrabdominal repair of uterus during caesarean delivery.
Method: This was a prospective comparative study of 150 caesarean deliveries. Randomization of the cases was irrespective of age, parity, indication and elective or emergency and was performed by two surgeons. Total of 150 cases were considered in the study and 75 cases performed by each surgeon were selected. One surgeon performed the surgery as intrabdominal repair while the other exteriorized the uterus for closure. Descriptive parameter and t-test were used.
Results: Intraoperative complications like intraoperative nausea, vomiting, pain were more commonly associated in cases in which uterus was exteriorized. In regards to severity of blood loss in either group there was no significant difference in either group (1.28±1.00, 1.23±0.98). The study revealed no significant difference in febrile morbidity and wound infections in either group.
Conclusions: There is no significant difference in the post-operative morbidity between the two groups but intraoperative peritoneal stretching pain was more when uterus was exteriorized.
Keywords: caesarean delivery, exteriorization, intrabdominal repair, uterine closure
Dental caries and periodontal disease prevalence and oral hygiene practices among Chepang female of Nepal
Authors: Pradhan Reema Joshi , Poudyal Sijan , Lamichhane Ramsudhan , Joshi Ujjwal
Published: May 2022

Aim: To explore the dental caries and periodontal disease and oral hygiene practice among the females in Chepang ethnic group.
Methods: Questionnaire were developed regarding socio-behavioral aspects in the prevention and control of dental caries and periodontal diseases at an individual and population level; and mechanical and chemical plaque control in the simultaneous management of gingivitis and dental caries. Data were collected and analyzed.
Results: Total 104 female patients were interviewed with their mean age of 30.1±12.7 (range: 11-70) years. 85.6% showed the regular brushing and 96.2% used the tooth brush and paste. 79% of the female brushes twice daily. Periodontal index and DMFT index showed good results.
Conclusions: Despite of tooth brushing practice the prevalence of periodontal disease and DMFT were significant. This could be associated with many other factors. Education and motivation of the population is required to improve the oral hygiene, oral hygiene measures and to refrain from habits.
Keywords: Caries, Chepang female, DMFT, Periodontal Index
Huge Subserosal Leiomyoma fed by serpentine omental blood vessels
Authors: Maskey Suvana , Gurung Geeta , Baral Josie , Paudyal Pooja
Published: May 2022

Leiomyoma is considered the most common benign tumor of genital tract with variable presentation and diverse operative findings. We are presenting a case of asymptomatic huge subserosal pedunculated leiomyoma in a 37 years unmarried nullipara lady diagnosed as highly vascular abdominopelvic mass preoperatively as suggested by imaging studies but of uncertain origin, imposing surgical challenge due to diagnostic dilemma and its vascularity. Laparotomy revealed solid mass of 26 x 24 cm occupying whole abdomen covered with torturous dilated serpentine vessels derived from omentum. The mass was arising from the fundus of bulky uterus with small pedicle suggesting suserosal pedunculated leiomyoma. Myomectomy with infracolic omentectomy with round ligament plication was done and her post operative recovery was smooth. Histological examination confirmed it as leiomyoma.
Keywords: Omentum, Pedunculated Leiomyoma, Serpentine
Types of plagiarism and how to avoid misconduct: Pros and cons of plagiarism detection tools in research writing and publication
Authors: Shah Jay N , Shah Jenifei , Baral Gehanath , Baral Reetu , Shah Jesifei
Published: May 2022

The ultimate journey of research and writing is publication. To see one’s name listed in the author's byline is an exciting feeling. This exciting feeling of authorship credit is linked with responsibility. The impact of the published work will depend on the dissemination of evidence-based scientific findings to help the health care workers, scientists, and policymakers for the benefit of society. This requires ethical research, to begin with, and publication without misconduct to maintain the integrity and trust in science. Among various misconducts in research writing and publication, plagiarism is serious scientific misconduct. The issue of plagiarism is a global concern that requires a collective effort from all stakeholders to prevent it and take prompt action if this issue does arise. Adequate teaching and training are necessary to increase awareness right from the early phases of learning; and to develop a culture of ethical research, writing, and publication. Types of plagiarism and its characteristics vary and should be dealt with accordingly, from a warning to definitive punishment for the offense committed. The software available to detect and avoid plagiarism is plenty and should be used taking into consideration their accuracy, usability, and cost.
Maternal and Fetal Outcomes in Active versus Expectant Management of prelabor rupture of membrane
Authors: Malla Rosy Vaidya , Khadka Shailaja , Thapa Sumana , Bidari Sumit , Acharya Indira , Neupane Bibhusan , Rai Kopila
Published: May 2022

Aim: To assess the effects of planned early birth (active treatment within 24hrs) compared to expectant management (without active treatment within 24hrs) for women at term with Prelabor Rupture of Membrane (PROM) on maternal and fetal outcomes.
Methods: This is an observational comparative study carried out in all the pregnant women who present in maternity ward of Shree Birendra Hospital with PROM at 37-41 weeks of gestation with vertex presentation during the study period between 13 April 2020 to 13 April 2021.They were randomly placed into (A) active treatment group and (B) expectant treatment group. Group (A) was induced with 25mcg of PGE1 (Misoprostol) depending on cervical score, whereas group (B) was expectantly managed for 24 hrs. PROM to delivery interval, maternal and fetal outcomes were then evaluated in both the groups.
Results: 79.5% of group A and 71.8% in group B delivered through vaginal route. 20.5% patients in group A and 28.2% patients in group B underwent Cesarean section. The average PROM to delivery interval was 15.6 hours in group A, as compared to 16.8 hours in group B. Only 2 babies in group B had an Apgar score of less than 7 at five minutes. Subsequently, in both the groups, two babies required NICU admission for respiratory distress syndrome with no neonatal mortality in both the groups.
Conclusion: Expectant management up to 24 hours can be safely offered to a woman with term PROM.
Diagnosis and management of ectopic ureter in a low resource setting – A case series
Authors: Heywood Shirley , Shrestha Shuvechchha Dewa
Published: May 2022

Aims:  To review the experience of women and girls treated for ectopic ureter in Surkhet through the fistula camps and Fistula Treatment Centre and analyse the diagnostic method, management and outcome.
Methods: This was a retrospective study of the patients with ectopic ureter who received treatment in Surkhet since 2009. Data were analysed from patient records and interviews.
Results:  Seven patients were diagnosed with ectopic ureter over a period of 12 years. Five patients were prepubertal with age range of  7 - 15 years. History of continuous incontinence with normal voiding was suggestive of ureteric fistula in six out of seven cases. The seventh case had massive ureterocele in the distal end of the duplex right ureter. Ultrasound suggested a diagnosis of duplex collecting system in five cases. IVU or CT IVU suggested duplex ureter in only three cases. Diagnosis was confirmed by examination under anaesthesia after i.v. frusemide in six cases. All cases were managed by implantation of the ectopic ureter into the bladder. In the case with ureterocele heminephrectomy was performed. All seven patients are well at follow-up between 6 months and five years after presentation.  
Conclusion: Ectopic ureter is a treatable cause of urinary incontinence and the diagnosis may be overlooked. A lifelong history of continuous urinary leakage with normal voiding, in absence of trauma or surgical procedure should raise the suspicion. Examination under anaesthetic and ultrasound proved most effective in confirming the diagnosis
Rawls’sA Theory of Justiceat Fifty
Authors: Audard Catherine , Forsé Michel
Published: May 2022

Throughout 2021, numerous celebrations, conferences and events took place to pay tribute to the Harvard philosopher John Rawls (1921-2001) and to his most famous book, A Theory of Justice published just fifty years ago in 1971. At the time, the publication became an immediate success worldwide and its influence has been deemed tremendous, the most commented and quoted philosophy book of the century. What was so special about it, was that it brought back to the forefront major normative political and moral issues such as the meaning of distributive justice and its value for democracies, as well as a definitive critique of welfarism. Through an evocation of Rawls’s impact as experienced in the States, in France and Europe, from different disciplines ranging from political and moral philosophy to economics and politics, this issue of The Tocqueville Review/La Revue Tocqueville will help to understand the complex nature of European-American cultural and political relations, well in the spirit of Tocqueville. This introduction to this issue presents the various contributions that have been brought together to achieve this goal.
COLLECTION OF THE WOMEN'S HEADDRESSES OF THE OLD BELIEVERS IN THE EXPOSITION OF THE ETHNOGRAPHIC MUSEUM OF THE PEOPLES OF TRANSBAIKALIA
Authors:   FSBEI HE «Irkutsk state university», Kostrov Alexandr Valeryevich , Galdanova Yulia Yuryevna ,   SAIC RB  «The Ethnographic Museum of the Peoples of Transbaikalia»
Published: May 2022

The article attempts to give an analytical review of the collection of the women's headdresses of the Old Believers stored in the Ethnographic Museum of the peoples of Transbaikalia. The quantitative and qualitative parameters of this collection are given in the article. The article reveals the specific features of kichkas, kokoshniks, pozatylnics and other components of the festive, everyday and death complexes in the context of the structural analysis and comparative correlation. The author comes to the conclusion that the information about this parameter of the Old Believers’ life has been collected in the course of such an activity.
THE PROBLEMS OF EVIL AND GOOD IN THE PROSAIC WORKS OF MODERN WRITERS
Authors:   FSBEI HE «East Siberian state Institute of culture», Nimaeva Irina Balzhinimaevna
Published: May 2022

The article tells about the moral problems touched upon in fiction. The solution of moral problems might serve guidance in the personality’s spiritual development in the process of her/his inculcation to human values in the prosa-ic works of Yu. Bondyrev, Ch. Aitmatov, V. Dudintsev, N. Luginov, A. Lyg-denov and other writers, in particular.
THE GAME SPACE MODEL: PREREQUISITIES AND DIRECTIONS OF RESEARCH
Authors:   FSBEI HE «East Siberian state Institute of culture», Matveeva Yelena Vladimirovna
Published: May 2022

Тhe article suggests the conception of studying the game as a phenom-enon inherent to human nature. The author analyzes some of the scientific the-ories of the game phenomenon based on the age-related peculiarities of human playful behavior. Several stages of the process of game consciousness for-mation are identified and characterized as the author's interpretation: game as an impulse; game as cognition, game as a way of social self-regulation. The re-search guidelines, the purpose and objectives of the coming concrete empirical research are formulated, which, in the author's plan, will allow to model the space for children's play creativity, the basis of which will comprise the values of game culture inherent to ethnic groups living in Eastern Siberia.
Potassium Permanganate Necrosis of the Vagina
Authors: Slaoui Aziz
Published: May 2022

A 19-year-old woman was referred to our emergency department for massive vaginal hemorrhage following an attempted clandestine abortion by intravaginal instillation of potassium permanganate crystals. Primigravida, she was 7 weeks pregnant and had no particular pathological history. Upon admission, she was in hemorrhagic shock with blood pressure at 7/3 mmHg and tachycardia at 152 bpm. Pelvic examination revealed active bleeding from the right vaginal wall. The cervix and vulva were normal. Mechanical hemostasis using a sterile gauze pad mounted on a long forceps was directly applied at the same time as the resuscitative management. After 3 minutes of compression, hemostasis was achieved and vaginal necrotic lesions appeared
Identification of Ways to Prevent and Overcome the Language Barrier in Foreign Language Classes
Authors: N.S Shvaikina , E.E Laryushkina
Published: May 2022

Some students lose their motivation to learn a foreign language at school, as they may have had a negative experience. In order for a teacher to increase motivation to learn a second language, it is necessary to create a situation of success.
Management of Pharmacotoxicologic Side Effects using Novel SONAPS Technologies
Authors: Alamdary Badlou Bahram
Published: May 2022

Patients who are daily suffering from drug abuse and pharmacotoxicologic side effects causing unnecessary hospitals’ visits, which unintentionally increase morbidity and mortality rate in- Hospital that the underlying mechanism still is not elucidate completely
Use of Dolutegravir in Hiv Treatment
Authors: Barbosa da Silva Emerson , Silva Matheus Carolina , Santos Chagas Camila dos , Rodrigues Pereira Daniela , Carvalho Garcias Anita de
Published: May 2022

The present work deals with the theme of the use of the retroviral Dolutegravir in the fight against the HIV virus, aiming to present the pharmacological aspects of the drug. The thematic focus was guided by two major interconnected questions: a) how has the evolution of the disease occurred in Brazil and which policies have been adopted in the fight against HIV/AIDS; b) how is Dolutegravir being used to face this epidemic? The methodological procedures adopted were the research of some normative documents and materials considered of reference in the area. As a result, it was evidenced that because it is a drug that had its use approved in August/2013 by the FDA in the USA and by the European Commission in January/2014, Dolutegravir presents itself as a new efficient pharmacological option for the treatment/coping of HIV/AIDS in the country, incorporated in 2017 to the ministry of health to minimize infection in patients with cross-resistance to other drugs used.
Neuroprotective Effect of Vitamin B6 and Vitamin B12 against Vincristine- Induced Peripheral Neuropathy: A Randomized, Double- Blind, Placebo Controlled, Multicenter Trial
Authors: Tasmin Jeenia Fatiha , Ahmed Sojib Ferdaush
Published: May 2022

Background: Vincristine leads to development of debilitating neuropathy in 40-45% patients with resultant compromised efficacy of chemotherapy, suboptimal treatment and worse prognostic outcome. Vitamin B6 and vitamin B12 improves non- oncological neuropathies. Therefore, this study investigated vitamin B6 and vitamin B12 to prevent vincristine- induced peripheral neuropathy (VIPN) by reducing incidence, absolute risk, relative risk, severity as well as delaying the onset. Methods: Patients with ALL undergoing induction phase were randomly assigned into intervention or placebo arm in a double- blind manner. Vitamin B6 (25 mg Pyridoxine) two tablets were given three times daily for 5 weeks. Vitamin B12 (500 μg/ml Methyl cobalamin) was administered intravenously on day 1, 3 and 5 of every week for 5 weeks during induction period. Placebo arm received oral and intravenous placebo for same duration. Patients were evaluated on the outset of every week by FACT/GOG-NTX questionnaire. Severity was assessed per NCI-CTCAE grading scale. Results: 102 patients were enrolled. Among them 81 completed the study, where 42 received vitamin B6 and B12 and 39 received placebo. There was significant difference in incidence of neuropathy between arms (26.19% intervention arm, 56.41% placebo; P-0.01). Relative risk of neuropathy was significantly (RR-0.46) lower in intervention arm. Besides, absolute risk reduction (ARR) was 30% and relative risk reduction (RRR) was 54%. NNT was 3.33. Significant trend was observed in difference of severity of VIPN between groups (P-0.03). No significant difference observed in between arms for time to onset of neuropathy. Conclusion: Vitamin B6 and vitamin B12 significantly reduced the incidence, relative risk and severity of VIPN. NNT was encouraging too. Henceforth, the status of vitamin B6 and vitamin B12 as neuroprotective agent against VIPN can be recommended as a promising one.
Cardiac Management in Covid-19 Patients
Authors: Hussain Md Sadique , Tyagi Swati
Published: May 2022

Coronavirus disease 2019 (COVID-19) was initially identified in late December 2019 in Wuhan, China. COVID-19 has spreaded swiftly over the planet, becoming a global pandemic affecting over 200 nations and territories, having an extraordinary impact not only on public health but also on social and economic activity.
PEMANFAATAN YOUTUBE SEBAGAI MEDIA KOMUNIKASI MASSA DIKALANGAN PELAJAR
Authors: Tinambunan Tresia Monica
Published: May 2022

ABSTRAKPembelajaran dengan media teks atau konvensional membuat pelajar kesulitan untuk memahami materi yang disampaikan oleh tenaga pengajar. Sehingga sekarang ini para pelajar memanfaatkan aplikasi Youtube sebagai penopang dalam kegiatan belajar. Penelitian ini bertujuan untuk mengetahui lebih dalam manfaat dari media Youtube bagi para pelajar dan penggunaan media sosial Youtube sebagai tempat untuk membagikan materi pelajaran. Penelitian ini menggunakan metode deskriptif dengan pendekatan kualitatif dan penelitian ini menggunakan teknik pengumpulan data mencakup penelitian jenis kepustakaan. Data yang digunakan dalam pentingnya penelitian ini adalah data sekunder. Hasil penelitian menunjukkan bahwa para pelajar yang memanfaatkan Youtube sebagai media komunikasi massa sangat mempermudah dalam mencari informasi atau pengetahuan yang diperlukan dan pelajar lebih mudah memahami materi yang terdapat dalam video dibanding materi yang disampaikan secara langsung oleh guru atau dosen baik secara daring ataupun tatap muka karena video yang ada pada aplikasi Youtube bisa diputar ulang kapan saja untuk mempelajari kembali bahan ajaran yang disampaikan.
Pengelolaan Dana Desa Untuk Peningkatan Kesejahteraan Masyarakat di Desa Kandangan Kabupaten Temanggung Tahun 2016 - 2018
Authors: Ramadhani Sarah Budi , Dewi Dyah Adriantini Sintha , Syafingi Habib Muhsin
Published: May 2022

Berdasarkan Pasal 25 Peraturan Menteri Keuangan Nomor 247/PMK.07/2015 tentang Tata Cara Pengalokasian, Penyaluran, Penggunaan, Pemantauan dan Evaluasi Dana Desa yang pada dasarnya penggunaan Dana Desa ini diprioritaskan untuk pembangunan dan pemberdayaan Desa dalam realisasinya belum berkorelasi dengan peningkatan kesejahteraan masyarakat. Hal ini setidaknya bisa dilihat dari data kemiskinan di Desa Kandangan, Kecamatan Kandangan, Kabupaten Temanggung yang tidak mengalami perubahan sejak tahun 2016 sampai dengan 2018. Angka kemiskinan tahun 2016 sebesar 551 KK, tahun 2017 mencapai 531 KK hingga akhir 2018 angka ini tidak berubah. Penelitian ini menggunakan metode normatif. Pendekatan penelitian dilakukan secara statute approach. Sumber data secara Primer (wawancara, peraturan perundangan) dan sekunder (kepustakaan). Teknik pengambilan data dilakukan secara studi pustaka, wawancara, observasi. Analisis data mengacu pada beberapa tahapan yang dijelaskan Miles dan Huberman.

Berdasarkan hasil penelitian dapat diketahui bahwa program pemberdayaan masyarakat saat ini belum mampu meningkatkan kesejahteraan masyarakat. Terbukti dari angka kemiskinan yang tidak berubah. Peneliti melihat program-program diatas tidak efektif dan belum tepat sasaran. Memang telah ada home industry, usaha mandiri masyarakat namun pihak pemerintah desa hanya membantu sebatas promosi saja. Padahal apabila menilik pada dana desa yang digunakan sebebsar 22% dari anggaran maka seharusnya anggaran tersebut mampu memberikan dampak walaupun sedikit. Artinya, perlu beberapa koreksi dan evaluasi rincian kegiatan pemberdayaan masyarakat. Dengan melihat faktor lingkungan, masyarakat dan menjalin pihak-pihak lain. Solusi yang dapat ditempuh adalah mengevaluasi pemerintahan desa dan membuka forum melibatkan warga yang terfokus pada pemberdayaan masyarakat. Sebisa mungkin program pemberdayaan masyarakat harus berkelanjutan atau sustainable. Program harus terfokus pada produk  home industry yang ada di Desa Kandangan mengingat potensi dari kegiatan tersebut mampu memberikan nilai positif dan menjalin stakeholder
Penyelesaian tindak pidana eigenrichting terhadap pelaku tindak pidana dalam perspektif antropologi hukum pidana
Authors: Saputra Wahyudi , Khakim Mufti
Published: May 2022

Penelitian ini bertujuan untuk menganalisis pola perilaku masyarakat tentang Eigenrichting dalam menanggapi suatu tindak pidana agar penyimpangan yang terjadi dari norma-norma sosial yang telah ditentukan dapat diperbaiki. Metode yang digunakan dalam penelitian ini adalah metode yuridis sosiologis dengan pendekatan kasus dan pendekatan konseptual. Lokasi penelitian bertempat di Desa Condongcatur, Depok, Sleman Yogyakarta. Bahan hukum yang digunakan dalam penelitian ini adalah bahan hukum primer dan bahan sekunder. Bahan hukum primer berupa Kitab Undang – Undang Hukum Pidana (KUHP) dan bahan hukum sekunder berupa buku – buku hukum hukum pidana dan artikel di jurnal hukum. Data primer diperoleh dari wawancara dilakukan kepada masyarakat Desa Condong Catur, Pemerintah Desa Condong Catur dan Kepolisian Resor Kabupaten Sleman. Bahan hukum dan data primer yang terkumpul kemudian dianalisis dan disajikan secara deskriptif. Hasil penelitian menunjukkan bahwa perilaku yang ada di masyarakat mengenai Eigenrichting disebabkan karena tingginya egoisme masyarakat yang ditambah dengan adanya tindakan provokasi, ketidakpercayaan masyarakat terhadap penegak hukum. Kondisi tersebut berakibat pelaku tindak pidana dihakimi oleh massa. Kurangnya kerjasama antara penegak hukum dan perangkat desa dalam memberikan penyuluhan sadar hukum, menyebabkan sulitnya mengatasi tindakan Eigenrichting di Desa Condong Catur.
Kajian Yuridis Perlindungan Merek Terhadap Gugatan Merek Nama Orang Terkenal
Authors: Heniyatun Heniyatun , Sulistyaningsih Puji , Iswanto Bambang Tjatur , Asiyah Yeni , Praja Chrisna Bagus Edhita
Published: May 2022

Penelitian ini bertujuan untuk mengetahui perlindungan merek terdaftar dan pertimbangan hakim dalam memutus Niet Ontvankelijke Verklaard (NO) Pengadilan Niaga Jakarta Pusat dengan nomor perkara 48/PDT.SUS/Merek/2018/PN.Niaga.Jkt.Pst. Di dalam posita menyebutkan bahwa singkatan nama “Bensu” merupakan singkatan nama orang terkenal, dan bahwa ayam Geprek Bensu milik penggugat merupakan merek terkenal, oleh karenanya penggugat mohon agar majelis hakim membatalkan merek Bensu milik Jessy. Namun perkara tersebut oleh Majelis Hakim Pengadilan Niaga diputus NO (Niet Ontvankelijke Verklaard) dengan mengabulkan eksepsi tergugat. Metode pendekatan dalam penelitian ini menggunakan pendekatan yuridis normative melauli pendekatan Undang-Undang dan pendekatan kasus. Hasil penelitian menunjukan bahwa perlindungan merek di Indonesia mengacu pada asas first to file, yaitu bahwa merek yang sudah didaftarkan memiliki perlindungan dan hak eksklusif, hanya dapat dibatalkan jika terbukti melanggar Undang-Undang. Putusan NO oleh Majelis Hakim dalam sengketa merek tersebut mengacu pada Pasal 28 Undang-Undang Nomor 20 Tahun 2016 Tentang Merek dan Indikasi Geografis (UU MIG) bahwa seharusnya penggugat mengajukan banding ke Komisi Banding Merek (KBM) lebih dahulu, karena merek milik penggugat belum terdaftar di DJKI. Hal ini sesuai Pasal 76 ayat 2 UU MIG bahwa merek yang belum terdaftar harus mengajukan gugatan kepada Menteri, selanjutnya Pasal 30 UU MIG menjelaskan bahwa keputusan KBM diberikan dalam jangka waktu tiga bulan. Namun Penggugat tidak menunggu tiga bulan sebagaimana putusan yang diberikan oleh KBM, akan tetapi langsung mengajukan gugatan ke Pengadiilan Niaga sehingga gugatan ditolak oleh Pengadilan Niaga dan dinyatakan cacat formil.
Tanggungjawab pengangkut terhadap hilangnya barang kiriman (studi kasus ekspedisi dharma raya Muntilan)
Authors: Saputri Rischa Indah , Iswanto Bambang Tjatur , Heniyatun Heniyatun , Nurwati Nurwati
Published: May 2022

Penelitian ini bertujuan untuk menganalisa tanggungjawab pengangkut terhadap hilangnya barang yang diangkut dan hambatan pengirim saat melakukan klaim ganti kerugian kepada pengangkut terhadap hilangnya barang. Jenis penelitian yang digunakan yuridis normatif, dengan pendekatan undang-undang (statute approach). Hasil penelitian menunjukkan bahwa dalam perjanjian pengangkutan, pengangkut bertanggungjawab terhadap barang yang dibawa mengacu berdasarkan Pasal 468 KUHD. Akan tetapi, dalam prakteknya saat proses pengangkutan sering terjadi barang hilang dikarenakan : a) barang dicuri bajing loncat; b) barang dicuri supir truk dan dijual kembali saat harga cabai mahal; c) barang dicuri saat bongkar di pasar; d) Barang dicuri saat barang disimpan di Kantor Ekspedisi Dharma Raya Muntilan. Hambatan pengirim cabai saat meminta ganti kerugian terhadap pengangkut ada 3 macam: a) Pengangkut terlambat memberikan laporan hilangnya barang kepada pengirim; b) Kurang teliti dalam menulis surat muatan; c) Pengangkut meminta tenggang waktu saat akan memberikan ganti rugi. Berdasarkan Pasal 468 KUHD yaitu perjanjian pengangkutan apapun faktor kehilangannya pengangkut harus memberikan pertanggungjawaban.
Dampak kebijakan asimilasi untuk pencegahan penyebaran virus Covid-19 terhadap statistik kejahatan di Magelang
Authors: Kurniaty Yulia , Yudha Awiek Prama , Krisnan Johny , Basri Basri
Published: May 2022

Penelitian ini bertujuan untuk mengetahui angka kriminalitas dan ragam penyakit masyarakat di Kota Magelang setelah diterapkannya kebijakan asimilasi bagi narapidana untuk mencegah terjadinya kluster baru di Lapas Kelas IIA Magelang. Untuk menjawab permasalahan penelitian digunakan metode penelitian lapangan guna memperoleh data primer angka kriminalitas dan ragam penyakit masyarakat di Unit Reskrim Polres Magelang Kota. Hasil penelitian ini menunjukan bahwa statistik kriminalitas di Kota Magelang setelah diberlakukannya Keputusan Kemenkumham tentang Pengeluaran dan Pembebasan Narapidana dan Anak melalui Asimilasi dan Integrasi dalam rangka Pencegahan dan Penanggulangan Penyebaran Covid-19 tidak meningkat. Adapun ragam kejahatan yang terjadi adalah pencurian, penipuan, penganiayaan, penggelapan dan pemerasan
Legal solutions of lake monitoring systems in Poland in compliance with the Water Framework Directive
Authors: Zębek Elżbieta Małgorzata
Published: May 2022

The Water Framework Directive 2000/60/EC is considered a very modern strategy of water management in the EU. The purpose is to establish a framework for the protection of inland surface waters by preventing further deterioration and protecting the condition of aquatic ecosystems, as well as increasing the protection and improvement of the condition of the aquatic environment by limiting emissions and losses of priority substances. It was considered that changes in the water law in Poland during the process of implementing the guidelines of the Water Framework Directive may have contributed to widening and strengthening the monitoring system of lakes and changes in their quality, especially their ecological state. This article aims to determine the changes in legal regulations in the field of water quality/ecologically state of lakes in Poland as a result of the implementation of the WFD. The EC reports indicate that some requirements are too rigorous and complicated for Member States to implement. Water monitoring was significantly expanded and modernised which lead to improvement of lake water quality in Poland. The five-grade ecological status of lake waters and standardised biological indicators were introduced. It was highlighted that the improvement of the WFD implementation process allowed for more effective water management and the development of effective strategies for the protection of lakes in Poland and other EU countries.
Forecast of radionuclide migration in groundwater of the zone affected by construction drainage at the Leningrad NPP-2
Authors: Erzova Valentina , Rumynin Vyacheslav , Nikulenkov Anton , Vladimirov Konstantin , Sudarikov Sergei , Vilkina Mariia
Published: May 2022

The distribution of natural (at the level of global background) and technogenic radionuclides in groundwater of the industrial zone in Sosnovy Bor town, where several nuclear power facilities are operating, was analyzed. The main technogenic radionuclides recorded in groundwater samples are cesium (137Cs), strontium (90Sr), and tritium isotopes. The first two aquifers from the surface are subject to contamination: the Quaternary and the upper zone of the Lomonosov aquifer. Based on extensive material on the engineering and geological studies of the work area, a 3D geological model and hydrodynamic and geomigration models of the industrial zone were constructed. By means of modeling, the extent and nature of changes in hydrogeological conditions of area resulting from the construction and operational drainage of the new stage of the Leningrad Nuclear Power Plant (LNPP-2) were determined. The “historical” halo of radioactive contamination of groundwater forming (1970-1990) at the site adjacent to the NPP, where the storage facility of low- and medium-level radioactive waste is located, falls into the zone of influence. Interpretation of monitoring data allowed obtaining the migration parameters for predictive estimates. Modeling has shown that during the time of the LNPP-2 operation there was no intake of contaminated water by the drainage system of the new power plant.
IMPLIKATUR KONVENSIONAL DAN NON KONVENSIONAL TUTURAN PENGUNJUNG KAWASAN LAWANG SEWU SEMARANG JAWA TENGAH
Authors: Arifianti Ika
Published: May 2022

The speech of visitors of the Lawang Sewu Semarang  is very interesting to study, because the average Lawang Sewu visitors come from outside of Semarang with diverse languages and social and educational backgrounds.  The way they deliver utterances is very diverse.  The use of implicature in language does not mean that it is not intentional or does not have a specific function. The use of implicature in language has considerations such as to refine speech, maintain ethics of politeness, to insinuate subtly (indirectly), and to avoid offending directly.  In implicative speech, the speaker and the interlocutor must have the same concept in a context.  There are conventional implicative forms of speech by visitors of Lawang Sewu area.  Conventional implications are the meanings of utterances that are conventionally or generally accepted by the public.  The approach used in this study is twofold, namely the theoretical research approach of nonconventional implications as expressions that imply something different from the actual and methodological esearch approach. The theoretical approach is used to test pragmatic analysis as the study.  The methodological research approach used is descriptive-qualitative method.
Early and late results of intravenous immunoglobulin as potential adjuvant therapies in critically ill COVID-19 patients: a retrospective cohort study
Authors: GÜRSOY Canan , ORAL TAPAN Özge , DOĞAN Emrah , PEKTAŞ Sinan , DEMİRBİLEK Semra
Published: May 2022

Introduction: Intravenous immunoglobulin (IVIG), which is one of the adjuvant therapy strategies, has been started to be used in critically ill COVID-19 patients due to its anti-inflammatory and immunomodulatory effects.

Material and Method: In our study, it was aimed to evaluate the effect of IVIG used in critically ill COVID-19 patients in the intensive care unit on early laboratory findings and late lung damage. Twenty-two critically ill COVID-19 patients who met the inclusion criteria were included in the study. Laboratory data of the patients who received 0.4 gr/kg/day IVIG for 5 days were analyzed before the treatment and on the 1st and 5th days of the treatment. For the percentage of injured lung areas was evaluated with chest CT.

Results: Respiratory rate and CRP decreased with IVIG, while an increase was observed in PaO2/FiO2, WBC, lymphocyte count, D-Dimer and fibrinogen values, which was statistically significant (p
The diagnostic value of calcium binding protein S100A8/A9 and S100A12 in acute pancreatitis
Authors: BARDAKCI Okan , DAŞ Murat , ŞEHİTOĞLU Hilal , ÜNAL ÇETİN Ece , ATALAY Ünzile , KÜÇÜK Uğur , KAMIŞ Fatih , TANOĞLU Alpaslan , BEYAZIT Yavuz
Published: May 2022

Background: S100A8/A9 and S100A12 which are the major calcium-binding proinflammatory proteins secreted by granulocytes, has been proposed to be related to distinct disease states of inflammatory origin. This study aims to explore the circulating levels of S100A8/A9 and S100A12 in acute pancreatitis (AP) and reveal their relationship with conventional inflammatory markers.
Material and Method: Serum S100A8/A9 and S100A12 were determined in AP patients (male/female: 17/13) by using a specific enzyme-linked immunosorbent assay (ELISA) method at both onset and remission and in 30 healthy controls (male/female: 17/13).
Results: Significantly higher S100A8/A9 and S100A12 levels were found in AP patients compared to healthy controls (p
Histopathological examination of the placenta after delivery in pregnant women with COVID-19
Authors: TAŞ Fatih , ERDEMCİ Fikri , AŞIR Fırat , MARAŞLI Mustafa , DEVECİ Engin
Published: May 2022

Introduction: COVID-19 is a viral disease generated by a new coronavirus named SARS-CoV-2. The consequences of this virus on the human placenta and the newborn are still unclear. IL-6 can disturb the placenta's immunological homeostasis and be employed as an inflammatory marker for the poor prognosis of COVID-19 infection. Bax has some features like being a key protein regulating apoptotic mechanisms and plays an important role in both maintaining dynamic balance and integrity in the placenta as in many tissues. This study aims to indicate the impact of COVID-19 on inflammation and apoptotic pathways in the placenta by using IL-6 and Bax antibodies.

Material and Method: COVID-19 positive (n:10) and COVID-19 negative (n:10) normotensive placentas were included. Haematoxylin-eosin staining and immunohistochemical staining (IL-6 and Bax antibodies) were applied. Statistical data of immunohistochemical (IL-6 and Bax expression) staining results were assessed by analyzing the H-score. Biochemical parameters were recorded. Group means were analyzed with a nonparametric Kruskal Wallis Test.

Results: In the COVID-19 group, increased syncytial knots, fibrin deposition, inflammation, fibrinoid necrosis, neutrophil accumulation were observed. The COVID-19 group had considerably higher levels of IL-6 and Bax expression than the control group. Furthermore, COVID-19 patients had statistically lower WBC and higher CRP values than normotensive patients.

Conclusion: COVID-19 has been linked to placental inflammation and trophoblast cell damage, both of which can result in major maternal and fetal problems during pregnancy. We found intense IL-6 expression in the placentas of pregnant women with COVID-19 infection. A rise in IL-6 levels triggers CRP production, and this increase is linked to the severity of COVID-19 as a risk factor. Also, we suggested that COVID-19 infection triggers the apoptotic process in placental tissue by increasing the expression of the proapoptotic Bax protein. It is clinically very significant to follow up COVID-19 positive pregnancies for maternal and fetal health. During this follow-up, IL-6 and Bax expression levels in the placenta, together with histopathological findings and serum CRP levels, can guide the evaluation of the prognosis, severity and response to treatment of the disease.
Overexpression of cytoplasmic dynamin 2 is associated with worse outcomes in patients with clear cell renal cell carcinoma
Authors: Safaei Sadegh , Sajed Roya , Saeednejad Zanjani Leili , Rahimi Mandana , Fattahi Fahimeh , Ensieh Kazemi-Sefat Golnaz , Razmi Mahdieh , Dorafshan Shima , Eini Leila , Madjd Zahra , Ghods Roya
Published: May 2022

BACKGROUND: Dynamin 2 (DNM2) involved in tumor progression in various malignancies. OBJECTIVE: For the first time, we evaluated DNM2 expression pattern, its association with clinicopathological characteristics and survival outcomes in RCC subtypes. METHODS: We evaluated the DNM2 expression pattern in RCC tissues as well as adjacent normal tissue using immunohistochemistry on tissue microarray (TMA) slides. RESULTS: Our findings revealed increased DNM2 expression in RCC samples rather than in adjacent normal tissues. The results indicated that there was a statistically significant difference between cytoplasmic expression of DNM2 among subtypes of RCC in terms of intensity of staining, percentage of positive tumor cells, and H-score (P= 0.024, 0.049, and 0.009, respectively). The analysis revealed that increased cytoplasmic expression of DNM2 in ccRCC is associated with worse OS (log rank: P= 0.045), DSS (P= 0.049), and PFS (P= 0.041). Furthermore, cytoplasmic expression of DNM2 was found as an independent prognostic factor affecting DSS and PFS in multivariate analysis. CONCLUSIONS: Our results indicated that DNM2 cytoplasmic expression is associated with tumor aggressiveness and poor outcomes. DNM2 could serve as a promising prognostic biomarker and therapeutic target in patients with ccRCC.
Designing Run-time Evolution for Dependable and Resilient Cyber-Physical Systems Using Digital Twins
Authors: Rivera Luis F. , Jiménez Miguel , Tamura Gabriel , Villegas Norha M. , Müller Hausi A.
Published: May 2022

The proliferation of Smart Cyber-Physical Systems (SCPS) is increasingly blurring the boundaries between physical and virtual entities. This trend is revolutionizing multiple application domains along the whole human activity spectrum, while pushing the growth of new businesses and innovations such as smart manufacturing, cities and transportation systems, as well as personalized healthcare. Technological advances in the Internet of Things, Big Data, Cloud Computing and Artificial Intelligence have effected tremendous progress toward the autonomic control of SCPS operations. However, the inherently dynamic nature of physical environments challenges SCPS’ ability to perform adequate control actions over managed physical assets in myriad of contexts. From a design perspective, this issue is related to the system states of operation that cannot be predicted entirely at design time, and the consequential need to define adequate capabilities for run-time self-adaptation and self-evolution. Nevertheless, adaptation and evolution actions must be assessed before realizing them in the managed system in order to ensure resiliency while minimizing the risks. Therefore, the design of SCPS must address not only dependable autonomy but also operational resiliency. In light of this, the contribution of this paper is threefold. First, we propose a reference architecture for designing dependable and resilient SCPS that integrates concepts from the research areas of Digital Twin, Adaptive Control and Autonomic Computing. Second, we propose a model identification mechanism for guiding self-evolution, based on continuous experimentation, evolutionary optimization and dynamic simulation, as the architecture’s first major component for dependable autonomy. Third, we propose an adjustment mechanism for self-adaptation, based on gradient descent, as the architecture’s second major component, addressing operational resiliency. Our contributions aim to further advance the research of reliable self-adaptation and self-evolution mechanisms and their inclusion in the design of SCPS. Finally, we evaluate our contributions by implementing prototypes and showing their viability using real data from a case study in the domain of intelligent transportation systems.
Goal and Feature Model Optimization for the Design and Self-Adaptation of Socio-Cyber-Physical Systems
Authors: Anda Amal Ahmed , Amyot Daniel
Published: May 2022

Socio-cyber-physical systems (SCPSs) are cyber-physical systems with social concerns. Many emerging SCPSs, often qualified as “smart”, need such concerns to be addressed not only at design time but also at runtime, often by adapting dynamically to surrounding contexts, to keep providing optimal value to users. A comprehensive requirements and design modeling approach is needed to incorporate social concerns (e.g., using goal modeling) into SCPS development activities. This paper introduces an optimization method that provides design-time and runtime solutions for self-adaptive SCPSs while supporting the validation of their design models. The method helps satisfying the goals of the SCPS and its stakeholders by monitoring the system’s environment and qualities, while enforcing correctness constraints specified in a feature model. We integrate arithmetic functions generated automatically from goal and feature models to build a combined goal-feature model and synchronize the values of the features shared between i) the objective function represented by goal functions, and ii) the constraints represented by feature functions. The goal-feature model is solved by an optimization tool (IBM CPLEX) in order to calculate optimal adaptation solutions for common situations at design time. Runtime optimization is also used by the system for adapting to situations unanticipated during design. We use a Smart Home Management System case study to assess how well the method can be used to manage selection among alternatives according to monitored environmental conditions while solving emergent conflicts. Further experiments on the use of the method for runtime adaptation show good performance for realistic models and good scalability overall. Some remaining challenges and limitations exist, including the availability of quantitative models as inputs.
Blockchain implementation for agricultural food supply chain using hyperledger fabric
Authors: Balasubramanian Suganya , Akila I.S.
Published: May 2022

Agricultural Food Supply chain management has arisen as an area of day-to-day importance for the agricultural food sector, since stakeholders involved in the execution of decision-making processes. Quality less agricultural products are added to the market in day-to-day life which leads to usage of chemicals in the production process. These leads to the major issues that gives the impact on agricultural product’s quality as well as overall well-being of the consumers. Devices are needed to identify the quality of the food products which are highly demanded due to the lack of transparency in the recent processes. Henceforth Blockchain technology is evolving as a decentralized and secure infrastructure which could replace involvement of a third party to verify the transactions inside the system. The purpose of the proposed work is to implement a Blockchain based solution i.e. constructing a Decentralized Application (DApp) using Hyperledger Fabric framework to verify the food quality and the cause of the agricultural supply chain. A private permissioned Blockchain concept is chosen instead of a public Blockchain in the proposed work to ensure transparency and secure transaction by consenting any person to access the network. Smart contract chain code was instantiated for the deployment of Blockchain network. All the performers who are involved in the supply chain must be able to interact with the system to achieve the transparency. Transaction and queries related to a food product are validated by peers of the Blockchain network. A Barcode & QR code-based scanning mechanism is used to indicate the customer’s satisfaction with their products. Transactions without third party gives Farmer’s reputation for their products. A unique DApp mechanism is used to identify each product within the food supply chain. Thus, the proposed system has been implemented as a prototype and validated using smart contracts.