bluuebunny/crossref_metadata_2025 huggingface dataset:
La insuficiencia de la categoría formal “sujeto/objeto” en el derecho
Authors: Dorado-Bravo Leidy , Portillo-Cabrera Jesús , Granizo-Haro Asdrúbal
Published: November 2021

Este artículo describe algunos escenarios complejos que permiten identificar la insuficiencia de la categoría formal sujeto/objeto en el derecho. Entre sujeto/objeto existe una relación en la que el primero se encuentra cualificado para dominar y disponer del segundo, lo que significa la aprehensión racional que excluye a la otredad y, en el derecho, se formaliza a través de la norma jurídica. La investigación parte de esta premisa y reflexiona sobre algunos ejemplos para identificar los escenarios jurídicos en los que la dualidad sujeto/objeto es insuficiente o presenta dificultades. A partir de los antecedentes teóricos y de la revisión documental, el trabajo precisa tres escenarios que agrupan los mayores desafíos de esta relación en el derecho: i) la línea germinal del ser humano, ii) la voluntad determinante en el sujeto, y iii) cuando el sujeto no es humano. Los resultados son interesantes porque, a pesar de que este es un tema muy relevante, hasta el momento existen pocos escritos que lo abordan en el país; en consecuencia, se espera que con este aporte se incentiven nuevas investigaciones que profundicen en los escenarios identificados.
La conceptualidad y realidad de la justicia indígena en el Ecuador
Authors: Delgado-Sayay Roberth
Published: November 2021

En el Estado ecuatoriano no solamente desde la constitución del 2008 vigente hasta la actualidad se reconoce el derecho a la administración de justicia de las colectividades indígenas a través de sus propias autoridades, siendo esta materia del análisis del presente artículo y es uno de los temas más que requiere de una atención y tratamiento especial dada a la situación de desventaja frente a la justicia ordinaria imperante dentro del territorio nacional. Dentro del estado unitario como se halla configurado el Ecuador la presencia de los sistemas jurisdiccionales entre ellos un sistema de justicia alternativa para la resolución de los conflictos resulta muy útil incluso para descongestionar la administración de justicia ordinaria dada a la alta demanda de los procesos judiciales.En este trabajo, al abordar el ejercicio de la administración de justicia indígena el análisis en las fuentes primarias y secundarias con énfasis de la normativa constitucional, instrumentos internacionales hasta legales, a su vez se evidencia la praxis propiamente dicha de estos procesos cuya panorámica no es nada alentador al no haberse desarrollado plenamente este sistema milenario.
Методологічні основи управління оборонними ресурсами в Збройних силах України
Authors: Semenenkо Oleh , Onofriichuk Petro , Chernyshova Iryna , Ostapets Oleh , Motrunych Ivan , Romanchenko Olha
Published: November 2021

В існуючих умовах розвитку держави, коли системи оборонного планування України адаптується до стандартів НАТО, розвиток Збройних Сил (ЗС) України повинен базуватися на показниках необхідного рівня обороноздатності країни з урахуванням її економічних можливостей щодо забезпечення потреб в оборонних ресурсах. Для України питання оборонного менеджменту, оборонного планування, який ґрунтується на принципах програмно цільового управління та управління оборонними ресурсами є недостатньо вивченим. Керівництво ЗС України та держави в цілому бажає найшвидше перейти до оборонного планування за стандартами НАТО, а саме із застосуванням методу “планування на основі спроможностей”. Проте нині в Україні відсутні методологічні основи управління оборонними ресурсами, що має негативні наслідки. Аналіз сучасних досліджень засвідчує, що сьогодні активно використовується термін управління оборонними ресурсами проте, в літературі зустрічається безліч його неоднозначних тлумачень. Крім того, важко знайти єдиний підхід до управління оборонними ресурсам. Тому необхідним та актуальним завданням є дати визначення терміну «управління ресурсами» та окреслити методологічні основи управління оборонними ресурсами в ЗС України. Сформовані методологічні основи повинні дати відповіді на питання щодо переліку, змісту та алгоритму реалізації методів управління оборонними ресурсами, а також розкрити питання практичної значимості процесу управління оборонними ресурсами. Пропоновані методологічні основи управління оборонними ресурсами за своєю сутністю є сукупність уточненого (стандартного для усіх рівнів ЗС України) понятійно-термінологічного апарату, розробленої концепції подальшого розвитку системи управління оборонними ресурсами та методичного апарату воєнно-економічного обґрунтування розвитку ЗС України, який являє собою набір методів, прийомів, способів дослідження питань управління оборонними ресурсами.

Подальші дослідження можуть бути пов’язані з розробленням практичних рекомендацій щодо створення та розвитку в ЗС України окремої ланки управління, яка відповідає безпосередньо за управління оборонними ресурсами.
Методичний підхід до визначення можливостей системи відновлення озброєння та військової техніки з технічної розвідки
Authors: Zvonko Andrey , Ovcharenko Igor , Yaroshenko Alexander , Pavlov Denis
Published: November 2021

Аналіз виконання бойових завдань підрозділами та військовими частинами ЗС України з зоні проведення антитерористичної операції (АТО) на території Донецької та Луганської областей вказує на зміну сучасних форм та способів застосування військ (сил), що призводить до необхідності удосконалення існуючих та пошуку нових способів виконання завдань з логістичного забезпечення, зокрема з відновлення пошкоджених зразків озброєння та військової техніки (ОВТ). Комплексна методика функціонування системи відновлення ОВТ включає два основних розрахункових блоки, а саме: методику визначення можливого обсягу втрат ОВТ та сил і засобів ремонтно-відновлюваних органів (РВО); методику визначення можливостей РВО щодо відновлення ОВТ, яка включає часткові методики визначення можливостей з технічної розвідки, евакуації та ремонту ОВТ.
Ітераційний метод “динамічної ефективності” при багатомірній задачі лінійного програмування для підвищення ефективності ресурсного забезпечення
Authors: Nevolnichenko Anatoly , Boiko Ruslan , Loishyn Anatolii
Published: November 2021

Типова задача оптимального розподілу ресурсів відома у дослідженні операцій як задача лінійного програмування з багатомірним аргументом, виникає при прийнятті рішень щодо управління “складною ергатичною бойовою системою (БС)” при її створенні («тендерна» задача) і застосуванні («транспортна» задача). “Тендерна” задача полягає у пошуку оптимального плану замовлень і постачань різнорідних ресурсів для створення елементів (об’єктів) структури БС, який максимізує ефективність використання бюджетних засобів (видатків). “Транспортна” задача полягає у пошуку оптимального плану замовлень і постачань різнорідних витратних ресурсів для відновлення боєздатності елементів (об’єктів) структури БС, яка підвищує ефективність використання витрат на ресурсне забезпечення. Якщо в тендерній задачі видатки є вартістю ресурсу і вартістю його постачання, то у транспортній задачі витрати є тільки “транспортними” (на постачання). В основу запропонованого методичного підходу пропонується універсальна постановка задач даного класу і універсальний ітераційний метод “динамічної ефективності” їх вирішення, що є розвитком методів теорії оптимальних рішень у воєнній кібернетиці. Головне практичне значення запропонованого підходу полягає в тому, що він дозволить вирішити даного класу задачі при незбалансованості постачання ресурсів.
Análise de práticas de Educação Ambiental em Escolas Públicas do Município de Olinda - Pernambuco
Authors: Vasconcelos Jamile Maria Pereira Bastos Lira de , Correia Dennis Bezerra , Verçosa Cícero Jorge , Santos Rafael Henrique Luciano dos , Figueirêdo Francileide Vieira , Anunciação José Aglailson Oliveira da , Cabral Clêidio da Paz , Santos Allyson Francisco dos , Oliveira João Paulo Camilo de , Oliveira Bruna Almeida de , Bento Elizângela Beneval , Figueroa Maria Eliana Vieira , Teixeira Pedro Hudson Rodrigues
Published: November 2021

A Educação Ambiental é um tema transversal geralmente incluído no currículo escolar nas disciplinas de Ciências e Geografia do ensino fundamental. O presente trabalho aborda as práticas e os entraves relacionados à Educação Ambiental (EA) na rede municipal de ensino do município de Olinda-PE. Para tal, procurou-se na literatura suporte para uma pesquisa empírica e analisando as práticas pedagógicas desenvolvidas em escolas da rede municipal e em setores públicos do município responsável por práticas de EA. Optou-se por pesquisas qualitativa e quantitativa através de entrevistas semiestruturadas com gestores e professores, além de observações diretas em departamentos responsáveis pelo ensino na rede pública. Os resultados revelam que a EA no município de Olinda necessita de políticas públicas que invistam em projetos contínuos de formação do estudante em uma EA transformadora e que a temática socioambiental precisa estar presente no currículo escolar de forma interdisciplinar. Foi possível identificar um descompasso entre o que os aportes teóricos tratam sobre EA e o que vem sendo feito na prática em algumas escolas do município de Olinda.
Situações de risco e vulnerabilidade em relação a possíveis transtornos mentais em crianças, adolescentes e mulheres
Authors: Silva Mariana Rodrigues , Coelho Isadora Sayonara Ferreira , Araújo Ruth Lany Barros , Morais Victor Emanoel da Silva , Silva Cleiton Veloso , Santos Thalita Cristina Oliveira , Nascimento Vinícius Sampaio Melo do , Leão George do Carmo , Salazar Devydiana da Silva , Santos Giovanna da Conceição dos , Rocha Francisca Jorlanna da Silva , Silva Luís Filipe Santos da , Santos Felipe Delmiro dos , Mesquita Eudilene da Silva , Santos Josefa Delmiro dos
Published: November 2021

A Organização Mundial de Saúde (OMS) destaca brevemente questões, em que uma a cada quatro pessoas desenvolvem transtornos mentais em seu período de vida. Buscando assim compreender a ocorrência de transtornos mentais em crianças, adolescentes e mulheres, o presente estudo objetivou analisar a ocorrência de transtornos mentais em crianças, adolescentes e mulheres em situações de risco ou vulnerabilidade bem como verificar as possíveis causas relacionadas a estes transtornos mentais e investigar os possíveis transtornos relacionados à criança, ao adolescente e à mulher. Para a realização desta pesquisa realizou-se um estudo transversal utilizando base de dados como BIREME e BVS, utilizando como fator de inclusão materiais publicados nos anos de 2015 a 2020. Os resultados apontam relação entre a ansiedade pré-natal materna com problemas emocionais na prole posteriormente, logo em se tratando da exposição à violência e sua repercussão na saúde mental do adolescente, características emocionais, aspectos relacionados à vulnerabilidade e uso de drogas na adolescência são fatores para desenvolvimento de transtornos mentais, já com relação à população infantil houve apenas resultados encontrados de materiais dessa temática relacionados às crianças autistas. Em síntese os estudos apontam o quanto questões de vulnerabilidade e situações de risco em crianças, adolescentes e mulheres colaboram consequentemente para quadros de adoecimento mental nos mesmos. Por fim, conclui-se que há uma necessidade de ampliação de estudos sobre o tema abordado ao qual, dessa forma contribuirá para melhores resultados e, consequentemente compreensão acerca os transtornos mentais relacionados à criança, adolescente e mulher.
Atividades biológicas da espécie spilanthes acmella: uma revisão
Authors: Dias Rafael Silva , Brasil Davi do Socorro Barros , Martelli Marlice Cruz
Published: November 2021

A proposta do trabalho é apresentar uma revisão bibliográfica sobre atividades biológicas em plantas da espécie Spilanthes acmella (L.).  A pesquisa foi realizada no período de setembro a novembro de 2019 e consistiu em uma busca na base de dados do SciFinder, considerando, os artigos publicados no período entre janeiro de 1959 e janeiro de 2021 e utilizando as palavras-chave: Acmella oleracea, Spilanthes acmella, antioxidante, antipirético e anti-inflamatório. Por meio desse processo resultou em 32 artigos encontrados endossando as atividades biológicas que são atribuídas à espécie Spilanthes acmella (L.), como as atividades inseticida e anti-inflamatória. Muitas atividades que eram atribuídas à planta Spilanthes acmella puderam ser comprovadas, assim como as substâncias biologicamente ativas e seus mecanismos de ação, em especial a atividade inseticida, que demonstrou grande potencial contra várias espécies de invertebrados.
Expondo os benefícios dos microrganismos aos seres humanos para alunos de Ensino Médio em São Luís-MA
Authors: Vila Nova Beatriz Gomes , Silva Lucas dos Santos , Sabóia Rafaella Santos , Alves Lully Gabrielly Silva , Gomes Paulo Dyago Borges , Galvão Lívia Câmara de Carvalho , Sousa Eduardo Martins de
Published: November 2021

Tratar dos microrganismos e os relacionar com o seu extenso leque de benefícios, no âmbito escolar, é de suma importância na perspectiva de deixar-se de lado o conceito de que os mesmos são apenas nocivos à saúde humana. O objetivo do projeto foi averiguar o que estudantes do ensino médio compreendem ou acreditam compreender sobre os microrganismos, e a partir disso, promover conhecimento e desfazer os conceitos distorcidos, assegurando que os microrganismos também são passíveis de benefícios. O projeto foi realizado no Colégio Marista Araçagy localizado no município de São José de Ribamar, no Maranhão, com alunos do 3º ano do ensino médio. Previamente os alunos foram pré-avaliados para que pudéssemos estimar seus conhecimentos acerca dos microrganismos e quão benéficos são. Logo em seguida o tema foi abordado com o auxílio de slides, onde definiu-se conceitos, benefícios e exemplos foram relatados.  Seguidamente, aplicou-se novamente um questionário com o intuito de mensurarmos o rendimento e aprendizado após os sujeitarmos à ação proposta. Após análise do questionário, verificou-se que dos 31 alunos que participaram, 39% não tinham conhecimento sobre a temática, enquanto 61% disseram já ter tido contato com o tema e 10% dos estudantes afirmaram que todas as bactérias são patogênicas. Só foi possível evidenciarmos um cenário animador após avaliarmos as respostas do segundo questionário. Contudo, favorecer conhecimento prévio sobre os microrganismos e seus benefícios é sem dúvida primordial na construção do saber acerca do que é verídico.
Infecção do trato urinário em gestantes: uma revisão integrativa
Authors: Silva Larissa Botelho da , Souza Pâmella Grasielle Vital Dias de
Published: November 2021

As infecções do trato urinário (ITU), são consideradas a complicação clínica mais frequente na gestação, ela surge devido uma falha no sistema de defesa contra os agentes instalados que podem provocar lesões de graus diversificados tanto para mãe quanto para o feto. O presente estudo aponta os principais agentes microbiológicos, as classificações clínicas, complicações advindas e condutas terapêuticas. Foi realizada uma revisão de literatura integrativa, utilizando artigos publicados entre os anos de 2016 e 2021, nas línguas portuguesa, inglesa e espanhola que foram publicados de forma íntegra nos bancos de dados PubMed, SciELO, LILACS e DeCS. As ITUs na gestação são causadas por fatores hormonais, anatômicos e fisiológicos, essas condições promovem o crescimento bacteriano. Essas infecções são normalmente ocasionadas por bactérias da microbiota intestinal que contaminam o trato urinário, destacando-se com maior predominância a Escherichia coli com 80% dos casos. Para um tratamento eficaz é preciso identificar a bactéria causadora da infecção, para selecionar o antibiótico adequado. Portanto, para a redução e controle dos casos de infecções do trato urinário, devem ser realizadas consultas de pré-natal e exames precoces para diagnosticar a infecção a fim de precaver possíveis complicações perinatais e maternas.
Planejamento e execução de mutirões de vacinação contraCOVID-19 no município de Manaus: relato de experiência
Authors: Machado Bruna Alves , Silva George Lucas Augusto Trindade da , Melo Giane Zupellari dos Santos , Santos Edinilza Ribeiro dos , Ribeiro Maria de Nazaré de Souza , Melo Mônica Lima de Melo e
Published: November 2021

Objetivo: Este artigo tem por objetivo descrever a experiência da equipe de planejamento e execução de mutirões de vacina contra o COVID-19 na cidade de Manaus, Amazonas. Metodologia: Trata-se de um estudo descritivo, do tipo relato de experiência, fundamentado e conduzido conforme Holiday que estabelece passos para sistematização de experiências. Relato de caso: A partir da vivência na campanha de vacinação contra a COVID-19 foi possível perceber a importância da vacina para a sociedade, em relação à prevenção da doença e consequentemente a redução da morbimortalidade. Sendo também fundamental a organização de mutirões de vacinação contra o COVID-19 e da necessidade de estes serem estruturados de forma eficaz e com trabalho em equipe. Considerações Finais: Este relato de experiência demonstra que para o alcance dos objetivos, desses mutirões, é necessário planejamento e trabalho em equipe, pois somente assim, foi possível alcançar as metas estabelecidas e pode-se seguir em constante assertividade tendo em vista a execução de quatro mutirões no município de Manaus que atingiu a meta de vacinar o público-alvo programado.
Reformulação do projeto editorial da Revista Informação na Sociedade Contemporânea
Authors: Silva Tarcísio Medeiros da , Medeiros Gustavo Luís Bezerra de
Published: November 2021

Este trabalho apresenta as sugestões para o processo de reformulação do projeto editorial da Revista Informação na Sociedade Contemporânea (RISC), periódico científico ligado ao Departamento de Ciência da Informação (DECIN) e ao Programa de Pós-.Graduação em Gestão da Informação e do Conhecimento da Universidade Federal do Rio Grande do Norte (UFRN). Objetivando determinar quais os elementos que deverão conter o projeto e qual política deve ser apresentada para que venha a ser um canal de desenvolvimento nesse tipo de publicação, comparar as políticas e processos editoriais da RISC com as de outros conceituados periódicos da área da Ciência da Informação, identificando e indicando as boas práticas editoriais para que elas sejam aplicadas. A análise comparativa se dará com as revistas: Informação & Sociedade, Perspectivas em Ciência da Informação e Transinformação.
EXAMINATION OF COVID-19 FEAR IN TERMS OF ITS DEFINING CHARACTERISTICS
Authors: ÇİMKE Sevim , YILDIRIM GÜRKAN Dilek , ESENKAYA Derya
Published: November 2021

Aim: The aim of the study is to determine the fear of coronavirus and affecting factors.
Method: It was conducted as a descriptive study. Data on participants were collected using an online questionnaire spread throughout the social media, e-mail and whatsapp groups. Socio-demographic questionnaire form, COVID-19 Fear Scale and Visual Analogue Scale (VAS) were used to collect data. Number, percentage, mean, t test, one way anova and pearson correlation analysis were used to evaluate the research data. The research was completed with 727 people.
Result: A statistically significant relation was found between the COVID-19 fear with age, gender, marital status, having children, having a chronic disease, working status and being health personnel, watching coronavirus news and always talk about coronavirus at home settings.
Conclusıon Accordingly, it is recommended to determine the fear of coronavirus in the society, to identify high-risk individuals by performing community screenings and to provide psychological support. It is very important to diversify and implement protective intervention programs in order to reduce some of the psychological consequences of fear and fear.
Water depth and mesoscale oceanography drive neustonic polychaete assemblages in the SE Pacific Ocean
Authors: Gusmao JB , Diaz O , Gallardo C , Hidalgo-Ruz V , Kiessling T , Mecho A , Meerhoff E , Rozbaczylo N , Thiel M
Published: November 2021

This study aimed to assess how oceanographic variables (depth, water temperature, and phytoplankton biomass) and the proximity to islands and seamounts affect the structure of neustonic polychaete assemblages across the SE Pacific Ocean. We used data from 2 oceanographic cruises and online databases to analyze how different environmental variables affect polychaete assemblages sampled at the sea surface. We hypothesized that (1) the proximity to islands and seamounts would have a positive effect on polychaete diversity, since islands and seamounts cause changes in local currents that can promote primary productivity; and that (2) changes in species composition would be related to large spatial scales, since major gradients in oceanographic variables are observed along a longitudinal gradient of the SE Pacific. Thirty polychaete taxa belonging to 14 different families were identified. All polychaetes were collected no further than 350 km from shallow geological features, such as seamounts or oceanic islands, indicating that mesoscale oceanographical processes drive neustonic polychaete assemblages. Polychaete abundance increased towards shallow waters and decreased with increasing distances from shallow geological features. Changes in species composition were related to gradients in latitude, longitude, and increasing distances to coastal systems. The most notable changes in assemblage structure were observed along the longitudinal gradient. These results indicate that the assemblage structure of neustonic polychaetes is the result of the interaction between mesoscale oceanographic processes related to shallow geological features and the major longitudinal gradients in productivity and temperature observed across the SE Pacific Ocean.
Fine-scale spatial and temporal acoustic occurrence of island-associated odontocetes near a mid-oceanic atoll in the northern Indian Ocean
Authors: Panicker D , Baumgartner MF , Stafford KM
Published: November 2021

Temporal patterns of oceanic predators can provide valuable information on both lunar and diel influences not just on the distributions of these predators, but also on prey patches that are often difficult to study. Mid-oceanic island chains in the northern Indian Ocean have high odontocete occurrence, but the ecology of these animals is not well characterized. We investigated fine-scale spatial and temporal patterns of island-associated odontocetes using passive acoustic monitoring from January 2019 to January 2020 around Kavaratti Island, Lakshadweep, India. Based on opportunistic recordings in the presence of odontocetes, the majority of the detected whistles were likely made by spinner dolphinsStenella longirostris. We identified a resident population whose whistle occurrence was significantly influenced by month, site, and diel and lunar cycles. More acoustic detections were made in the northeast monsoon month of November and fewer during pre-monsoon and southwest monsoon periods. Distinct day-night differences along with fine-scale temporal variability were also observed, suggesting that delphinids use nearshore waters as a daytime resting habitat. Odontocete detections were highest during the new moon period and lowest during the first quarter phase. Detection rates were higher on the south side of the island. Our study shows that solar and lunar cycles modulate odontocete vocal occurrence, presumably through influences on their prey. Similarities of odontocete occurrence around Lakshadweep to other mid-oceanic island chains suggests that an island-associated micronekton community may exist around Lakshadweep that may also be important to other pelagic species targeted by local fisheries.
Use of Chemical Dosimetry for Comparison of Ultrasound and Ionizing Radiation Effects on Cavitation
Authors: Kratochvíl B. , Mornstein V.
Published: November 2021

A comparison of the effects of ultrasound produced by low- and high-frequency ultrasonic apparatuses upon biological systems is one of the basic problems when studying ultrasound cavitation effects. One possibility for how to compare these effects is the indirect method which uses well-known physical quantities characterizing the interaction of ionizing radiation with matter and which also converts these quantities to one common physical quantity. The comparison was performed with two methods applied to the chemical dosimetry of ionizing radiation. The first method employed a twocomponent dosimeter which is composed of 50 % chloroform and 50 % re-distilled water (i.e. Taplin dosimeter). The other method used a modified iodide dosimeter prepared from a 0.5 M potassium iodide solution. After irradiation or ultrasound exposure, measurable chemical changes occurred in both dosimeters. The longer the exposure, the greater the chemical changes. These effects are described by the relationship of these changes versus the exposure times in both dosimeters. The UZD 21 ultrasonic disintegrator (with a frequency of 20 kHz, 50 % power output) was used as a lowfrequency ultrasound source, and the BTL-07 therapeutic instrument (with a frequency of 1 MHz and intensity of 2 W/cm2 ) was used as a high-frequency cavitation ultrasound source. For comparison, a 60Co gamma source was applied ( 60Co, gamma energies of 1.17 and 1.33 MeV, activity of 14 PBq). Results of this study have demonstrated that the sonochemical products are generated during exposure in the exposed samples of both dosimeters for all apparatuses used. The amount of these products depends linearly upon the exposure time. The resulting cavitation effects were recalculated to a gray-equivalent dose (the proposed unit is cavitation gray [cavitGy]) based on the sonochemical effects compared to the effects of ionizing radiation from the 60Co source.
ORGANIZATION OF THE MULTIMODAL TRANSPORTATION OF THE GOODS ON THE AIR TRANSPORT
Authors:   National Aviation University, Kyiv, Ukraine, I Borets , O Sokolova ,   National Aviation University, Kyiv, Ukraine, O Soloviova ,   National Aviation University, Kyiv, Ukraine, I Vysotska ,   National Aviation University, Kyiv, Ukraine
Published: November 2021

The article is devoted to the development of methods infolohichnoho modeling and simulation polierhatychnoho documentary describing the test bearing properties nanomaterials that determine the endurance and technological resources mixtures structural components pavement layers in terms the variety effects to cover non-stationary environment and traffic. Formalized mathematical description models and methods necessary for the system CM-PD as hardware and software testing technology polierhatychnoho structure formation nanomaterials under technical and technological orders endurance performance evaluation and resource material layers work surfaces for safe movement traffic forecasting. The peculiarities the modes interaction and the language simulation ergatic modeling for the search rational technologies creation road materials are substantiated. The proposed analytical tools aimed at forming the structure silicon-carbon polymers and composites with expected force-moment and mass-energy physicochemical properties to counteract the effects heterogeneous factors non-stationary environment. The method infological modeling processes for providing conditions for the purposeful between atomic and molecular interactions in the limited local spatial volumes is developed. Formalized parametrization of mutual functions distribution concentrations, pressure and temperatures, which jointly accelerates the stage thermodynamic self-organization and controlledly form the domain-granular structures substances artificial structural materials (SCM) road cover. The information analytical tools the KM-PD system provide the reliability the estimates endurance interval, mechanical strength, integrated resource, obtained by the methods simulation the MSC and in general, KSSSDO. Mixtures substances withstand similar effects from environmental factors and respond equally to microphase spatial separation compatible component components. The maximum levels energy efficiency ordered load bearing coverings are the achievement for the operation the transport and road complex with non-stationary flows moving objects on the surfaces the future ITS infrastructure provided by the agreed levels multiple heterogeneous interactions. KEY WORDS: THERMODYNAMIC SYNTHESIS, FORMATION OF NANOSTRUCTURES, DOCUMENTARIES DECISION, INFORMATION TECHNOLOGY, INFOLOHICHNE MODELING, CARRYING LAYERS TRANSPORT INTERACTION CRITERION SIMILARITY SECURITY RESOURCE SPACE SELF-ORGANIZATION.
INVESTIGATION OF ROTATIONAL AND LONGITUDINAL MOTIONS OF A SUPER LONG ROD IN INCLINED BORE-HOLES
Authors:   National Transport University, Kyiv, Ukraine, I Gorbunovich , L Levkivska ,   National Transport University, Kyiv, Ukraine
Published: November 2021

The article deals with a super long elastic tubular rod with an internal fluid flow. The rotational and longitudinal motions of straight and curved rods in inclined bore-holes are studied. The bifurcation states of the rod at these motions are investigated. The purpose of the study is to detect at the beginning of bifurcation states of straight and curved rods taking into account their friction interaction with the inner surface of a bore-holes. The reasons of appearance of bifurcation protrusion of the rod are stated. Among these reasons, an internal longitudinal force and torque are identified and described as main ones. Research methods are based on the construction of boundary-value problems determining the stress­strain state and stability of super long straight and curved rods in an inclined bore-hole. Solving the problems allows detecting the beginning of bifurcation states of rods. KEY WORDS: SUPER LONG ROD, STRIGHT AND INCLINED BORE-HOLE, ROTATIONAL AND LONGITUDINAL MOTIONS, BIFURCATION STATES, LONGITUDINAL FORCE, TORQUE.
INFLUENCE OF TEMPERATURE OF THE ENVIRONMENT ON PROPERTIES OF MOTOR OILS
Authors:   National Transport University, Kyiv, Ukraine, M Dmytrychenko , A Milanenko ,   National Transport University, Kyiv, Ukraine, O Bilyakovych ,   National Transport University, Kyiv, Ukraine, A Savchuk ,   National Transport University, Kyiv, Ukraine, Y Turitsa ,   National Transport University, Kyiv, Ukraine, M Kosenko ,   National Transport University, Kyiv, Ukraine
Published: November 2021

The article presents the results of studies that were conducted on the SMC-2 tribometer according to the ring-sleeve scheme in conditions of non-shocking sliding friction due to the rotational motion of the roller. In order to perform experimental studies of the processes of friction and wear of metal vapors and to study mechanical-physicochemical processes in the interaction of a steel-steel pair, in our experiment we studied motor all-season oils of different chemical composition on the rheological basis: motor oils of semisynthetic origin TEMOL 10 synthetic origin and TEMOL Premium synthetic origin origin of TEMOL Premium 5W-40. The aforementioned oils were tested for 15 min under conditions of temperature rise from minus 180C to plus 750C. The purpose of the work is to minimize the friction processes in the conditions of forced increase of the volume temperature of engine oil in engines of type D-241 and engine of concern Volkswagen VAG ASV 1.9 TDI. The method of investigation is the experimental determination of the rheological features of motor oils and the antifriction properties of friction pairs. According to the results of experimental studies, it is established that the stability of the formation of film thickness with increasing temperature, starting from low temperatures, gives synthetic oils some advantages at low-temperature starting, that is, to the conditions of realization of mixed friction (lubrication starvation). Semi-synthetic oil has some advantages in the formation of the thickness of the lubricating layer under conditions of liquid friction at moderate temperatures, which is explained by the formation of a thickness of greater magnitude, has better viscoelastic properties in these conditions of fluid friction. It is established that oils of semisynthetic and synthetic origin have excellent antifriction properties and this can be explained by their stable to mechanical degradation properties in the conditions of accelerated warming of the internal combustion engine. KEYWORDS: ENGINE OIL, RHEOLOGICAL CHARACTERISTICS, ANTIFRICTION PROPERTIES, FILM THICKNESS.
EVALUATION DOMESTIC AND FOREIGN TRANSPORTATION HUB WORK EXPERIENCE
Authors:   National Transport University, Kyiv, Ukraine, M Zakharchenko
Published: November 2021

The article deals with the peculiarities of domestic and foreign experience hubs. The object of study - the process of multimodal transport hubs in traffic. The purpose of the work - in analyzing the domestic and foreign experience of transport nodes to identify ways to improve multimodal transport nodes. The research method is analytical. The most important structural unit of multimodal transport systems are multimodal transport nodes. By the term multimodal transport hub (MTH) understand the geographical point of docking and interaction of several types of transport, through which multimodal transportation is carried out. Such a hub may combine the railway stations connecting their railways, sea and river ports, airports, stations, highways, terminal and intermediate objects of main pipelines, and municipal transport networks. The infrastructure of the MTH includes warehouses and cargo terminals with traffic control and distribution centers, customs clearance facilities, transport insurance, organizations representing freight forwarding and banking services. In the analysis of domestic and foreign experience of transport hub, it was discovered that transport nodes are the bridgeheads of organizational-technical and technological interaction of different types of transport, implementation of multimodal transportations on logistic principles. The capacity of transport hubs in Ukraine is at a critical point. In modern conditions, the power of transport hubs is not sufficient for the volume of freight traffic, including and transit grew. In order to eliminate "bottlenecks" in transport hubs of Ukraine, it is necessary to improve the technical and operational capabilities of the infrastructure objects, their technical re-equipment and modernization. The results of the work can be applied to develop measures for the improvement of multimodal transport hubs. Foreseeable assumptions about the development of the research object - the search for ways to improve multimodal transport hubs. KEY WORDS: MULTIMODAL TRANSPORTATION, MULTIMODAL TRANSPORT HUBS, WAYS OF CONNECTION.
SOME ASPECTS OF THE DEVELOPMENT OF SOCIO-ECONOMIC ORGANIZATION
Authors:   National Transport University, Kyiv, Ukraine, O Markov
Published: November 2021

The article presents the theoretical substantiation of the resource approach method proposed by the author for solving the issue of continuous support for the effectiveness of the functioning of a socio­economic organization. The urgency of the problem is due to the significant influence of the Soviet personnel mentality on the effectiveness of the organization. The subject of the study is three types of resources: investment, functional and development resources. Three states of organization are considered: in statics, in the process of functioning and dynamics. The dynamics of changes in the state of the organization in the field of positive and negative selection, as well as the pattern of changes in the state of the organization due to functional and development resources are shown. The effectiveness of development resources compared to functional resources is shown. The conclusions boil down to the fact that development resources are a significant factor in improving the efficiency of an organization that is not yet used in the practice of our business. KEYWORDS: SOCIO-ECONOMIC ORGANIZATION; SYSTEM; FUNCTION; REPORTS; ORGANIZATION DYNAMICS
Do different languages train our brain in different ways? The discussion of typological distance and its influence in the bilingual brain
Authors: Lee Yan-Yi
Published: November 2021

As we come to understand that a unified cognitive outcome of bilingualism is unlikely, attention is now more often directed to the factors that may leave an impact on the bilingual brain. One element that has started to receive attention is that of L1-L2 typological distance. In this presentation, I make the case that the scientific foundations to develop this line of inquiry are still not firm. I begin by arguing that the concept of ‘typological distance’ is overly generic and not firmly concretised in the realm of bilingualism research. Furthermore, discussions on how bilingual cognitive demands are formed as a result of L1-L2 typological distance, along with how such demands are connected to the aspect of skill, are fundamental yet underpowered. Finally, the significance of bilingual neural activity and neurostructural changes has yet to be concretised before conclusions on the influence of typological distance can be formed.
The Theology Of The Incarnation: A Paradigm For A Theology Of Contextual In The Era Of The Third Millennium
Authors: Ranto Ranto
Published: November 2021

Why is it necessary to learn the Theology of the Incarnation, it is not separated from some of the advantages of basic and very critical of the approach of this theology.  First, the Theology of the Incarnation to take the role as a theology of contextual provided the Bible itself, and that God has taken this pattern in the states themselves, and his word to man. This is the pattern and the case of biblical theology and contextual theology in the context of health.  Next, as an example the case of theology is contextual, the role of the incarnation embodies well the demands of the two mandates the basis of theology is contextual.  In this case, God and His Word are eternal it is final, eternal, and unchangeable in the encounter, and ‘incarnation” in humanity and human culture. While at the same time, there is no doubt that it is relevant and following the bible.
Relationship Between Serum Amino Acid Levels and Bone Mineral Density: A Mendelian Randomization Study
Authors: Cui Zhiyong , Feng Hui , He Baichuan , He Jinyao , Tian Yun
Published: November 2021

Background

This study aimed to explore the association between serum amino acids (AAs) levels and bone mineral density (BMD).

Methods

We performed a two-sample Mendelian randomization (MR) analysis to analyze the associations between the levels of eight AAs and BMD values by using summary-level genome-wide association study (GWAS) data. We applied the MR Steiger filtering method and MR Pleiotropy RESidual Sum and Outlier (MR-PRESSO) global test to check for and remove single nucleotide polymorphisms (SNPs) that were horizontally pleiotropic. The associations were estimated with the inverse variance weighted (IVW), MR-Egger, weighted median and MR Robust Adjusted Profile Score (MR.RAPS) methods.

Results

Our study found that genetically increased isoleucine (Ile) [IVW: effect = 0.1601, 95% confidence interval (CI) = 0.0604 ~ 0.2597, p = 0.0016] and valine (Val) levels (IVW: effect = 0.0953, 95% CI = 0.0251 ~ 0.1655, p = 0.0078) were positively associated with total body BMD (TB-BMD). The results also revealed that genetically increased tyrosine (Tyr) levels were negatively associated with TB-BMD (IVW: effect = -0.1091, 95% CI = -0.1863 ~ -0.0320, p = 0.0055).

Conclusions

In this study, associations between serum AA levels and BMD were established. These findings underscore the important role that serum AAs play in the development of osteoporosis and provide evidence that osteoporosis can be prevented and treated by the intake of certain AAs.
DNA Methylation Differences Between Zona Pellucida-Bound and Manually Selected Spermatozoa Are Associated With Autism Susceptibility
Authors: Wang Longda , Chen Mengxiang , Yan Gaofeng , Zhao Shuhua
Published: November 2021

Children conceived through intracytoplasmic sperm injection (ICSI) have been reported to have a higher risk of many abnormalities and disorders, including autism and intellectual disability, which may be due to bypassing of the natural sperm selection process during ICSI. Zona pellucida (ZP)-bound spermatozoa (ZPBS) have normal morphology and nuclear DNA. Using these spermatozoa for ICSI results in better outcomes compared with conventional ICSI. However, differences besides morphology that exist between sperm selected by ZP and by an embryologist and whether these differences affect the risk of autism in offspring after ICSI are unclear. To explore these questions, we compared genome-wide DNA methylation profiles between ZPBS and manually selected spermatozoa (MSS)using single-cell bisulfite sequencing. Global DNA methylation levels were significantly lower in ZPBS than in MSS. Using gene ontology (GO) analysis, genes overlapping differentially methylated regions (DMRs) were enriched in biological processes involving neurogenesis. Furthermore, we found that 47.8% of autism candidate genes were associated with DMRs, compared with 37.1% of matched background genes (P<0.001). This was mainly because of the high proportion of autism candidate genes with bivalent chromatin structure. In conclusion, bivalent chromatin structure results in large differences in the methylation of autism genes between MSS and ZPBS. ICSI using MSS, which increases the risk of methylation mutations compared with ZPBS, may lead to a higher risk of autism in offspring.
Urinary mRNA Signatures as Predictors of Renal Function Decline in Patients With Biopsy-Proven Diabetic Kidney Disease
Authors: Lee Yu Ho , Seo Jung-Woo , Kim Miji , Tae Donghyun , Seok Junhee , Kim Yang Gyun , Lee Sang-Ho , Kim Jin Sug , Hwang Hyeon Seok , Jeong Kyung-Hwan , Moon Ju-Young
Published: November 2021

The clinical manifestations of diabetic kidney disease (DKD) are more heterogeneous than those previously reported, and these observations mandate the need for the recruitment of patients with biopsy-proven DKD in biomarker research. In this study, using the public gene expression omnibus (GEO) repository, we aimed to identify urinary mRNA biomarkers that can predict histological severity and disease progression in patients with DKD in whom the diagnosis and histologic grade has been confirmed by kidney biopsy. We identified 30 DKD-specific mRNA candidates based on the analysis of the GEO datasets. Among these, there were significant alterations in the urinary levels of 17 mRNAs in patients with DKD, compared with healthy controls. Four urinary mRNAs—LYZ, C3, FKBP5, and G6PC—reflected tubulointerstitial inflammation and fibrosis in kidney biopsy and could predict rapid progression to end-stage kidney disease independently of the baseline eGFR (tertile 1 vs. tertile 3; adjusted hazard ratio of 9.68 and 95% confidence interval of 2.85–32.87, p < 0.001). In conclusion, we demonstrated that urinary mRNA signatures have a potential to indicate the pathologic status and predict adverse renal outcomes in patients with DKD.
Progress of the Art of Macrophage Polarization and Different Subtypes in Mycobacterial Infection
Authors: Ge Gai , Jiang Haiqin , Xiong Jingshu , Zhang Wenyue , Shi Ying , Tao Chenyue , Wang Hongsheng
Published: November 2021

Mycobacteriosis, mostly resulting from Mycobacterium tuberculosis (MTb), nontuberculous mycobacteria (NTM), and Mycobacterium leprae (M. leprae), is the long-standing granulomatous disease that ravages several organs including skin, lung, and peripheral nerves, and it has a spectrum of clinical-pathologic features based on the interaction of bacilli and host immune response. Histiocytes in infectious granulomas mainly consist of infected and uninfected macrophages (Mφs), multinucleated giant cells (MGCs), epithelioid cells (ECs), and foam cells (FCs), which are commonly discovered in lesions in patients with mycobacteriosis. Granuloma Mφ polarization or reprogramming is the crucial appearance of the host immune response to pathogen aggression, which gets a command of endocellular microbe persistence. Herein, we recapitulate the current gaps and challenges during Mφ polarization and the different subpopulations of mycobacteriosis.
Prognostic Influence of Residual Tumor-Infiltrating Lymphocyte Subtype After Neoadjuvant Chemotherapy in Triple-Negative Breast Cancer
Authors: da Silva Jesse Lopes , de Albuquerque Lucas Zanetti , Rodrigues Fabiana Resende , de Mesquita Guilherme Gomes , Fernandes Priscila Valverde , Thuler Luiz Claudio Santos , de Melo Andreia Cristina
Published: November 2021

Objective

This study aimed to examine the prevalence and prognostic role of tumor microenvironment (TME) in triple-negative breast cancer (TNBC) after neoadjuvant chemotherapy (NACT) through immunohistochemical characterization.

Methods

The internal database of the Brazilian National Cancer Institute for women diagnosed with TNBC who underwent NACT and thereafter curative surgery between January 2010 and December 2014 was queried out. Core biopsy specimens and tissue microarrays containing surgical samples of TNBC from 171 and 134 women, respectively, were assessed by immunohistochemistry for CD3, CD4, CD8, CD14, CD56, CD68, CD117, FOXP3, PD-1, PD-L1, and PD-L2. Immune cell profiles were analyzed and correlated with response and survival.

Results

Mean age was 50.5 years, and most cases were clinical stage III [143 cases (83.6%)]. According to the multivariate analysis, only Ki67 and clinical stage significantly influenced the pattern of response to systemic treatment (p = 0.019 and p = 0.033, respectively). None of the pre-NACT IHC markers showed a significant association with event-free survival (EFS) or overall survival (OS). As for post-NACT markers, patients with high CD14 had significantly shorter EFS (p = 0.015), while patients with high CD3 (p = 0.025), CD4 (p = 0.025), CD8 (p = 0.030), CD14 (p = 0.015), FOXP3 (p = 0.005), high CD4/FOXP3 (p = 0.034), and CD8/FOXP3 (p = 0.008) showed longer EFS. Only high post-NACT CD4 showed significantly influenced OS (p = 0.038).

Conclusion

The present study demonstrated that the post-NACT TIL subtype can be a determining factor in the prognosis of patients with TNBC.