bluuebunny/crossref_metadata_2025 huggingface dataset:
Advances in research on malignant transformation of endometriosis-associated ovarian cancer
Authors: Chen Fang , Zhu Mengying , Li Wenjuan
Published: October 2024

Endometriosis (EMs) is a prevalent chronic gynecological condition that depends on estrogen, marked by the presence of active endometrial tissue (glands and stroma) outside the uterus. Although pathologically benign, it exhibits biological behaviors such as invasion and metastasis akin to malignant tumors. Endometriosis-associated ovarian carcinoma (EAOC), arising from malignant transformation of EMs, poses significant clinical challenges. However, the mechanisms underlying EAOC pathogenesis remain incompletely understood, with a lack of reliable biomarkers for early diagnosis and personalized treatment strategies. Considering the significant number of EMs patients and the extended period during which malignant transformation can occur, EAOC deserves significant attention. Current research both domestically and internationally indicates that the pathogenesis of EAOC is complex, involving genetic mutations, immune microenvironment, oxidative stress, epigenetic changes, and related areas. This review summarizes the mechanisms underlying the development of EAOC.
Facilitators and barriers of adherence to rectal interventions by parents of young children with functional constipation: a qualitative study
Authors: Shen Haiyan , Zhang Li , Zhang Yu , Huang Yan , Xu Banghong , Yu Mingming
Published: October 2024

Background

Functional constipation in children is a worldwide problem that impacts both children's gastrointestinal function and the quality of family life. The treatment of this condition often depends on parental involvement to administer rectal interventions to their children to stimulate defecation. However, adherence to rectal interventions is currently suboptimal. We sought to explore the factors that facilitate and hinder parents from adherence to rectal interventions.

Methods

A descriptive qualitative study was conducted involving semi-structured interviews with parents of infants and young children with functional constipation requiring rectal interventions from March to May 2023. The data were analyzed using content analysis.

Results

Fourteen parents participated in the study. Parents reported the main facilitators of adherence to prescribed rectal interventions as recognition of illness severity, support from family and friends, and medical resource support and e-health literacy. Parents reported the primary barriers as information barriers, family conflict, cognitive misalignment, and difficulties in accessing healthcare services.

Conclusion

Rectal interventions are often essential in managing constipation in young children, with parental compliance being crucial for effective treatment. Healthcare providers must consider the psychosocial aspects of parents’ perceptions, adhere to guidelines to standardize communication, and ensure comprehensive education to improve medication literacy.
Zhachong Shisanwei pill drug-containing serum protects H2O2-Induced PC12 cells injury by suppressing apoptosis, oxidative stress via regulating the MAPK signaling pathway
Authors: Hu Hanqiong , Sun Yifan , Yang Zhen , Che Limuge , Cai Mingyang , Li Xiaoxuan , Huang Xianju , Bagen Hurile , Qiqige Wulan , Guleng Wuyunsiri , Ma Liqun , Tong Haiying
Published: October 2024

Introduction

Zhachong Shisanwei Pill (ZSP) is a classical Mongolian formula that combines 13 types of Chinese medicinal materials and has been used for treating ischemic stroke (IS) for centuries. However, the underlying molecular mechanisms have yet to be fully elucidated. The aim of this study is to explore potential mechanism of ZSP on nerve cells in cerebral ischemic injury.

Methods

To simulate the pathological process of oxidative stress following IS, an injury model using PC12 cells was induced with hydrogen peroxide (H2O2). Afterward, PC12 cells were treated with ZSP medicated serum at low, medium, and high doses. Various assays were conducted to assess cell viability and oxidative stress indicators, including lactate dehydrogenase (LDH), malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), reactive oxygen species (ROS), and mitochondrial membrane potential (MMP). Cell apoptosis was evaluated through morphological assessment and flow cytometry. Additionally, the expression levels of apoptosis-related proteins (Bcl-2, Bax, Caspase-9, Caspase-3, PARP) and signaling pathway proteins (JNK, phosphorylated JNK, ERK, phosphorylated ERK, p38, and phosphorylated p38) were measured using automated Western blotting.

Results

Our findings indicate that ZSP medicated serum preconditioning improves the condition of PC12 cells injured by H2O2. Specifically, it increased cell survival rates and reduced LDH release. Additionally, ZSP treatment decreased ROS levels and MDA content, while enhancing the activity of SOD and CAT in the injured PC12 cells. ZSP also reversed the depolarization of mitochondrial membrane potential and protected cells from apoptosis by modulating the expression of apoptosis-related proteins, including Bcl-2, Bax, Caspase-9, Caspase-3, and PARP. Furthermore, the overactivation of the MAPK signaling pathway due to H2O2-induced injury was inhibited, as evidenced by the downregulation of phosphorylated JNK, ERK, and p38 levels.

Discussion

Mongolian medicine ZSP demonstrates protective effects against H2O2-induced oxidative stress and apoptosis in PC12 cells. The underlying mechanism may involve the inhibition of the MAPK signaling pathway, enhancement of antioxidant enzyme activity, reduction of intracellular peroxidation levels, and suppression of intrinsic apoptosis pathways.
The NEDD4/FLRT2 axis regulates NSCLC cell stemness
Authors: Yang Yuping , Yan Fei , Gao Ziwei , Li Houke , Wen Shengke , Li Qi , Li Jiayuan , Huang Na , Zhao Wei
Published: October 2024

Introduction

Lung cancer is the leading cause of cancer-related death worldwide. The treatment for lung cancer, particularly for non-small cell lung cancer (NSCLC), remains a clinical challenge. Cancer stem cells are vital for lung cancer development. This study aimed to determine the influence of the neuronally expressed developmentally downregulated 4-fibronectin leucine-rich transmembrane 2 (NEDD4-FLRT2) axis on cancer cell stemness in NSCLC.

Methods

FLRT2 expression in NSCLC tissues and stem cells was investigated using western blot and RT-qPCR. The sphere formation assay and the abundance of stemness markers were employed to confirm the stemness of NSCLC stem cells. The CCK-8, colony formation, and Trans-well assays, as well as flow cytometry, were used to determine NSCLC stem cell growth, metastasis, and apoptosis, respectively. The Co-IP assay was used to confirm the binding between NEDD4 and FLRT2. Xenograft tumor mouse models were used to investigate tumorigenesis in vivo.

Results

Here, we reported that FLRT2 expression was reduced in NSCLC tissues, cells, and NSCLC stem cells. FLRT2 upregulation inhibited NSCLC stem cell proliferation, sphere formation, and drug resistance and promoted drug-resistant cell apoptosis. Furthermore, FLRT2 overexpression demonstrated antitumor effects in a xenograft tumor mouse model. Mechanically, FLRT2 was ubiquitinated and degraded by E3 ligase NEDD4. NEDD4 overexpression significantly abolished the inhibitory effects of FLRT2 on NSCLC stemness, as evidenced by in vitro and in vivo experiments.

Discussion

This study revealed that FLRT2 acted as a tumor suppressor by inhibiting cancer cell stemness in NSCLC. NEDD4 promoted ubiquitination degradation of FLRT2 protein. NEDD4 counteracted the inhibitory effects of FLRT2 on NSCLC stem cell tumorigenesis.
Insights about exosomal circular RNAs as novel biomarkers and therapeutic targets for hepatocellular carcinoma
Authors: Zhang Haiyan , Pei Shanshan , Li Jiaxuan , Zhu Jiajie , Li Hongyu , Wu Guangshang , Weng Ruiqi , Chen Ruyi , Fang Zhongbiao , Sun Jingbo , Chen Keda
Published: October 2024

One of the most prevalent pathological types of Primary Liver Cancer (PLC) is the Hepatocellular Carcinoma (HCC) poses a global health issue. The high recurrence and metastasis rate of HCC, coupled with a low 5-year survival rate, result in a bleak prognosis. Exosomes, small extracellular vesicles released by various cells, contain diverse non-coding RNA molecules, including circular RNAs (circRNAs), which play a significant role in intercellular communication and can impact HCC progression. Studies have revealed the potential clinical applications of exosomal circRNAs as biomarkers and therapeutic targets for HCC. These circRNAs can be transferred via exosomes to nearby non-cancerous cells, thereby regulating HCC progression and influencing malignant phenotypes, such as cell proliferation, invasion, metastasis, and drug resistance. This review provides a comprehensive overview of the identified exosomal circRNAs, highlighting their potential as non-invasive biomarkers for HCC, and suggesting new perspectives for HCC diagnosis and treatment. The circRNA from exosomal organelles promotes metastasis and immune scape because of their unique chirality which is different from the Biomolecular Homochirality.
Synthesis and characterization of activated carbon-supported magnetic nanocomposite (MNPs-OLAC) obtained from okra leaves as a nanocarrier for targeted delivery of morin hydrate
Authors: Öziç Cem , Ertaş Erdal , Baran Mehmet Fırat , Baran Ayşe , Ahmadian Elham , Eftekhari Aziz , Khalilov Rovshan , Aliyev Elvin , Yıldıztekin Mahmut
Published: October 2024

Introduction

The method of encapsulating the drug molecule in a carrier, such as a magnetic nanoparticle, is a promising development that has the potential to deliver the medicine to the site where it is intended to be administered. Morin is a pentahydroxyflavone obtained from the leaves, stems, and fruits of various plantsmainly from the Moraceae family exhibiting diverse pharmacological activities such as anti-inflammatory, anti-oxidant, and free radical scavenging and helps treat diseases such as diabetes, myocardial infarction and cancer.

Methods

In this study, we conducted the synthesis of a nanocomposite with magnetic properties by coating biocompatible activated carbon obtained from okra plant leaves with magnetic nanoparticles.

Results

Characterization of the synthesized activated carbon-coated magnetic nanocomposite was confirmed by Fourier transform infrared, scanning electron microscopy, dynamic light scattering, and zeta potential. The cytotoxic effects of the drug-loaded magnetic nanocomposite were examined in HT-29 (Colorectal), MCF-7 (breast), U373 (brain), T98-G (Glioblastoma) cancer cell lines, and human umbilical vein endothelial cells healthy cell line.

Discussion

We studied the loading and release behavior of morin hydrate in the activated carbon-coated magnetic nanocomposite. Activated carbon-coated magnetic nanocomposite carriers can show promising results for the delivery of Morin hydrate drugs to the targeted site.
Air cold plasmas as a new tool for nitrogen fixation in agriculture: underlying mechanisms and current experimental insights
Authors: Aceto Domenico , Ambrico Paolo F. , Esposito Fabrizio
Published: October 2024

Nitrogen fixation is crucial for plant growth and global agriculture, especially with the projected population growth requiring a significant increase in food production. Traditional nitrogen fixation relies on the Haber-Bosch (H-B) process, which is energy-intensive and environmentally harmful due to greenhouse gas emissions. Emerging technologies, such as cold plasma, offer promising alternatives with lower energy consumption. Cold plasma facilitates reactive nitrogen species generation under ambient conditions, potentially improving the production efficiency of nitrogen oxides (NOx). However, optimizing cold plasma nitrogen fixation requires a synergy between experimental and theoretical approaches. Accurate input data are essential for refining theoretical models, which can then guide the design of more efficient processes. This integrated approach can leverage renewable energy, operate on smaller scales, and minimize environmental impacts, making cold plasma a sustainable solution for future nitrogen fixation needs.
YOLOv8-licorice: a lightweight salt-resistance detection method for licorice based on seed germination state
Authors: Sha Mo , Fu Xiuqing , Bai Ruxiao , Zhong Zhibo , Jiang Haoyu , Li Fei , Yang Siyu
Published: October 2024

Seeds will display different germination states during the germination process, and their good or bad state directly influences the subsequent growth and yield of the crop. This study aimed to address the difficulties of obtaining the images of seed germination process in all time series and studying the dynamic evolution law of seed germination state under stress conditions. A licorice sprouting experiment was performed using a seed sprouting phenotype acquisition system to obtain images of the sprouting process of licorice in full-time sequence. A labeled dataset of licorice full-time sequence sprouting process images was constructed based on the four states of unsprouted, sprouted, cracked, and shelled in the sprouting process. An optimized model, YOLOv8-Licorice, was developed based on the YOLOv8-n model and its effectiveness was demonstrated by comparative and ablation tests. Different salt stress environments were simulated via NaCl aqueous solution concentration, and germination experiments of licorice seeds were performed under different salt stresses. The germination state of licorice under different salt stress environments was detected using the YOLOv8-Licorice detection model. Percentage curve of licorice seeds in an unsprouted state displayed a continuous decreasing trend. For the percentage curve of licorice seeds in the sprouted state, an increasing and then decreasing trend was observed under the condition of 0-200 mmol/L NaCl solution, and a continuous increasing trend was observed under the condition of 240-300 mmol/L NaCl solution. Licorice seeds in the cracked state demonstrated percentage curves with an increasing and then decreasing trend under the condition of 0-140 mmol/L NaCl solution and a continuous increasing trend under the condition of 160-300 mmol/L NaCl solution. The percentage curve of licorice seeds in shelled state displayed a continuous increasing trend in 0-200 mmol/L NaCl solution condition and remained horizontal in 220-300 mmol/L NaCl solution condition. Overall, this study provides a valuable method involving the seed sprouting phenotype acquisition system and the proposed method for detecting the germination state of licorice seeds. This method serves as a valuable reference to comprehensively understand the seed sprouting process under triggering treatment.
The roles of Magnaporthe oryzae avirulence effectors involved in blast resistance/susceptibility
Authors: Liu Xin , Hu Xiaochun , Tu Zhouyi , Sun Zhenbiao , Qin Peng , Liu Yikang , Chen Xinwei , Li Zhiqiang , Jiang Nan , Yang Yuanzhu
Published: October 2024

Phytopathogens represent an ongoing threat to crop production and a significant impediment to global food security. During the infection process, these pathogens spatiotemporally deploy a large array of effectors to sabotage host defense machinery and/or manipulate cellular pathways, thereby facilitating colonization and infection. However, besides their pivotal roles in pathogenesis, certain effectors, known as avirulence (AVR) effectors, can be directly or indirectly perceived by plant resistance (R) proteins, leading to race-specific resistance. An in-depth understanding of the intricate AVR-R interactions is instrumental for genetic improvement of crops and safeguarding them from diseases. Magnaporthe oryzae (M. oryzae), the causative agent of rice blast disease, is an exceptionally virulent and devastating fungal pathogen that induces blast disease on over 50 monocot plant species, including economically important crops. Rice-M. oryzae pathosystem serves as a prime model for functional dissection of AVR effectors and their interactions with R proteins and other target proteins in rice due to its scientific advantages and economic importance. Significant progress has been made in elucidating the potential roles of AVR effectors in the interaction between rice and M. oryzae over the past two decades. This review comprehensively discusses recent advancements in the field of M. oryzae AVR effectors, with a specific focus on their multifaceted roles through interactions with corresponding R/target proteins in rice during infection. Furthermore, we deliberated on the emerging strategies for engineering R proteins by leveraging the structural insights gained from M. oryzae AVR effectors.
Girls play basketball too? A study of the mechanisms of traditional social gender consciousness on female participation in contact leisure sports
Authors: He Yushan , Su Guibin , Wang Lujuan , Qian Haonan
Published: October 2024

Background

With the development of women’s sports, the mechanism of barriers to women’s leisure sports participation has attracted extensive attention from the academic community. Despite its significant impact, there are few empirical studies on intra-personal barriers. Consequently, a structural equation model was established to examine the relationships between traditional social gender awareness, gender bias, gender stereotypes, and barriers to participation in leisure sports.

Methods

In this study, a total of 508 questionnaires were collected and analyzed using AMOS 24.0 software for structural equation modeling. After model testing, the relationships between the variables were examined.

Results

The results of the statistical analyses indicated that traditional gender awareness could serve as an antecedent variable for barriers to participation in leisure sports, and that gender stereotypes mediated the relationship between traditional gender awareness and barriers to participation in leisure sports. The study also concluded that gender bias could not mediate the relationship between traditional gender awareness and participation barriers in leisure sports, but gender bias and gender stereotypes could act as chain mediators in the process of the influence of traditional gender awareness on barriers to contact leisure sports.

Discussion

This study emphasizes the need for women to break down the traditional social gender awareness, gender bias, gender stereotypes, and other intra-personal barriers when engaging in leisure sport participation. According to this study, the promotion of sustained and healthy development of women’s sport requires the breaking down of traditional social gender awareness education and the creation of more gender-inclusive sports policies and environments. The significance of the study is that by proposing and confirming the internal participation barriers to women’s participation in contact leisure sports, it will lead to the ideological liberation of women’s gender perspectives, so that they can break down the participation barriers to contact leisure sports, participate in sports activities, and enjoy the right to play sports on an equal footing.
The use of induced pluripotent stem cells as a platform for the study of depression
Authors: Villafranco Javier , Martínez-Ramírez Gabriela , Magaña-Maldonado Roxana , González-Ruvalcaba Anna Paola , López-Ornelas Adolfo , Velasco Iván , Becerril-Villanueva Enrique , Pavón Lenin , Estudillo Enrique , Pérez-Sánchez Gilberto
Published: October 2024

The neurobiological mechanisms underlying major depressive disorder (MDD) remain largely unexplored due to the limited availability of study models in humans. Induced pluripotent stem cells (iPSCs) have overcome multiple limitations of retrospective clinical studies, contributing to a more detailed understanding of the molecular pathways that presumably contribute to the manifestation of depression. Despite the significant progress made by these study models, there are still more formidable challenges that will eventually be addressed by these platforms, as further studies may eventually emerge. This review will examine the most recent advances in the comprehension of depression by using human neurons and non-neuronal cells derived from induced pluripotent stem cells of patients with depression. This study highlights the importance of using these platforms to increase our knowledge of depression and address this psychiatric disorder more efficiently.
Environment-related health risks, knowledge and awareness among people in precarious milieus: secondary data analysis from the German “Environmental Awareness Study”
Authors: Duda Annabell , Reifegerste Doreen
Published: October 2024

Introduction

Precarious milieus more frequently suffer from environmental risks and show lower environmental awareness and behavior than other milieus in the German population. This study investigates the factors that influence environmental awareness in precarious milieus and the roles of environmental knowledge and the perception of environment-related health burdens.

Methods

A quantitative secondary data analysis of the German Environmental Awareness Study 2018 (N = 2017) was used to analyze the perception of environmental health burdens, environmental knowledge, and environmental awareness between precarious milieus (n = 190) and seven other milieus. One-way analysis of variance (ANOVA) and Bonferroni post hoc tests were used for this purpose. More in-depth analyses of the precarious milieus were carried out using multiple regression analyses.

Results

There were significant differences in the perceptions of environmental health burdens affected by rail-traffic noise and neighborhood noise. Furthermore, environmental knowledge in precarious milieus was significantly lower than in five out of the seven other milieus (all p < 0.001) and was significantly associated with environmental cognition and gender. Precarious milieus had higher environmental affect than established milieus but less than that of critical-creative milieus and young idealists (all p < 0.001). Environmental cognition and environmental behavior were significantly associated with environmental affect. Environmental cognition was significantly higher in precarious milieus than in established milieus and among young pragmatists but was lower than in critical-creative milieus and among young idealists (all p < 0.001). Environmental affect, environmental knowledge, and gender were significantly associated with environmental cognition. In precarious milieus, environmental behavior was significantly lower than in traditional milieus and critical-creative milieus and among young idealists (all p < 0.001) and was significantly associated with environmental affect.

Conclusion

The differences in the perception of environmental health burdens, environmental knowledge, and environmental awareness among precarious milieus indicate that there is a need for specific education and support structures for these population groups. Further research is needed to determine what other factors within the precarious milieus influence environmental knowledge and awareness, as well as the skills needed to understand environmental information, which are included in the framework of environmental (health) literacy.
Integrating digital and interactive approaches in adolescent health literacy: a comprehensive review
Authors: Mancone Stefania , Corrado Stefano , Tosti Beatrice , Spica Giuseppe , Diotaiuti Pierluigi
Published: October 2024

Adolescent health literacy is critical for navigating the complex landscape of modern healthcare and making informed decisions that influence long-term health outcomes. This comprehensive review synthesizes current research on integrating digital tools and interactive learning approaches to enhance health literacy among adolescents. We explore the use of digital technologies, such as mobile apps and virtual reality, which cater to the preferences of this tech-savvy generation, offering personalized and accessible health information. The effectiveness of interactive learning methodologies, including simulations and role-playing, is also examined, highlighting their potential to increase engagement and retention of health-related knowledge. We address the importance of mental health literacy and the role of social media and peer education in disseminating health information effectively. Our review identifies gaps in the current literature, particularly the need for studies that consider long-term outcomes and the impact of socioeconomic and cultural factors on health literacy initiatives. We propose a multidimensional approach to health literacy education that incorporates innovative technologies and interactive methods to meet the diverse needs of adolescents in various contexts. The findings suggest that an integrated approach, including digital and critical health literacy, is essential for developing comprehensive health education programs that are both informative and engaging for adolescents.
Knowledge, attitudes, and support needs of obstetric and gynecological nurses and midwives toward perinatal mental health disorders screening in Central China: a multicenter cross-sectional survey
Authors: Zhu Luyang , Pan Xinlong , Chen Chunli , Chen Jianfei , Pan Yuanrui , Chen Xiaoli , Zou Zhijie , Li Chengqiu
Published: October 2024

Background

The perinatal period is a time of increased vulnerability regarding maternal mental health status. Although guidelines and policies have been published for perinatal mental health disorders (PMHDs) screening in China, the knowledge, attitudes, and support needs of nurses and midwives toward implementing mental health screening programs during pregnancy remain unclear. Thus, this study aimed to investigate the knowledge of PMHDs, attitudes and support needs related to implementing mental health screening during pregnancy among obstetrics and gynecology (OB/GYN) nurses and midwives in the central region of China while identifying the related influencing factors.

Methods

A cross-sectional survey was conducted in 14 cities in Hubei, China, using convenience sampling from July to October 2023. The Chinese version of the Perinatal Mental Health Knowledge Questionnaire, the Chinese version of the Perinatal Mental Health Attitudes Scale, and the Health Care Facilities Support Needs Scale were used to investigate the PMHDs knowledge, attitudes, and support needs of OB/GYN nurses and midwives, respectively. Data were analyzed using SPSS version 27.0. Descriptive and inferential statistics were performed, with a p-value of <0.05 considered statistically significant.

Results

The average scores for knowledge, attitudes, and support needs were 6.09 ± 1.99 (total score: 13), 47.67 ± 8.80 (total score: 80), and 29.35 ± 4.66 (total score: 35), respectively. After adjusting for years of nursing experience and years of obstetrics and gynecology nursing experience, the multivariate logistic regression analysis indicated that having mental health-related education or work experience [adjusted OR (aOR) = 1.43, p = 0.01], being midwives (aOR = 1.78, p < 0.001), and working in specialist maternity hospitals (aOR = 1.55, p < 0.001) were significantly associated with higher knowledge scores; having mental health related education or work experience (aOR = 1.59, p = 0.014) and working in specialist maternity hospitals (aOR = 1.42, p < 0.01) were significantly associated with higher support needs scores.

Conclusion

OB/GYN nurses and midwives demonstrated insufficient knowledge and moderate attitudes toward PMHDs screening, and have great support need for PMHDs screening. To address these issues, medical organizations and relevant government sectors should enhance training for nurses and midwives on PMHDs and provide professional support to promote routine maternal mental health screening programs and improve perinatal mental health outcomes.
Prevalence of injury and utilization of personal protective equipment among building construction workers and associated factors in Bale and West Arsi Zones, southeast Ethiopia 2022
Authors: Aliyi Ahmednur Adem , Hashim Mohammed Abdela , Abdurebi Muhammed Jemal
Published: October 2024

Introduction

The building construction industry is well known for being one of the most dangerous industries worldwide. Statistics show it is one of the most dangerous occupations in the world. The aim of this study is to assess the prevalence of injury, personal protective equipment usage among building construction workers, and associated factors in Southeast Ethiopia.

Methods

Institutional-based cross-sectional study was done among 406 selected construction workers in Southeast Ethiopia. Study participants were selected randomly. Data were collected by using a structured questionnaire. Descriptive statistics was used to summarize study variables. Binary logistic regression was utilized to investigate factors associated with injury among study participants. Accordingly, adjusted odds ratio along its 95% confidence interval were calculated and a p value of <0.05 was used to declare statistical significance. Generalized linear models were utilized to investigate factors associated with the use of personal protective equipment. Accordingly, an adjusted odds ratio with a 95% confidence interval was determined and a p value of <0.05 was used as a level to declare a significant statistical association.

Result and discussion

In this research 406 building construction workers were interviewed and 393 participants gave complete responses, yielding a 96.8% response rate. Of all participants included in this study, 27 (6.8%) drink alcohol and 26 (6.6%) chew khats. Uses of personal protective equipment among study participants was 133 (33.3%, with a 95% confidence interval of 28.3% to 37.7%). Of 393 participants in this study, 213 (54.2%) of them sustained at least one building work-related injury in the last year. The commonest type of injury that occurred among this population was abrasion 43.3% followed by muscular pain (13%). Not having orientation about personal protective equipment, without safety training, didn’t use personal protective equipment, and rural residence were factors significantly associated with injury among building construction workers. Residence, age, monthly income, service year, orientation about personal protective equipment, safety training, and start using personal protective equipment immediately after the job offers were significantly associated with the uses of personal protective equipment by participants of this study. In general, this study has identified a relatively high prevalence of injury and low use of personal protective equipment in the study subjects and associated factors.
Education and socioeconomic status as predictors of refugee mental health: insights from a study of Jordan-based Syrian refugee sample
Authors: Atrooz Fatin , Khabour Omar F. , Almomani Fidaa , Aljararwah Sally , Alfurjani Batool H. , Salim Samina
Published: October 2024

Background

The Syrian civil war is considered as the greatest humanitarian crisis in modern history, which has resulted in a major refugee crisis. A significant concern is the high prevalence of mental disorders such as depression, anxiety, and post-traumatic stress disorder (PTSD) among Syrian refugees. While the focus of most refugee mental health research has been pre-migration trauma, post-migration challenges and stressors, which can also be significant determinants of mental health, are often ignored. The purpose of this study was to assess mental health of Syrian refugees as compared to local Jordanians, and to examine sociodemographic factors and perceived stressors that are associated with mental distress among participants.

Methods

This was a cross sectional study conducted in northern region of Jordan among Syrian refugee and Jordanian adults. We used the validated Arabic version of Afghan Symptoms Checklist (ASC) to assess mental distress among participants.

Results

A total of 929 subjects (43% Syrian refugees, 56% females) participated in this study. Disparities in education, monthly income, and health insurance were significant between Syrian refugees and Jordanians, p < 0.001. The mean score in ASC was significantly higher among Syrian refugees, particularly among refugee females (mean ASC score ± standard deviation: Syrian refugee females: 58.22 ± 1.13; Syrian refugee males: 45.31 ± 1.28; Jordanian females: 51.06 ± 0.91; Jordanian males: 46.45 ± 1.08, p = 0.002). Multivariable linear regression showed that the estimated difference in the mean of ASC score between males and females is 7.42 (p < 0.001), and the estimated mean difference between Syrian refugees and Jordanians is 2.76 (p = 0.019). Interestingly, the estimated mean of ASC scores for individuals with high education level is decreased by 4.18 as compared to individuals with lower education level (high school or less), p < 0.001.

Conclusion

Education level was highly predictable of mental distress of Syrian refugees, particularly female refugees. Enhancing higher educational opportunities is proposed for improving socioeconomic status of refugees which might serve as a buffering strategy for mental distress among this vulnerable population.
Validity and reliability of the Polish version of the Pregnancy Mobility Index (PMI-PL)
Authors: Antosiak-Cyrak Katarzyna , Ratajczak Joanna , Lewandowska Magdalena , Wochna Krystian , Sobczak Katarzyna , Domaszewska Katarzyna , Rąglewska Patrycja , Urbański Piotr , Czerniak Urszula , Demuth Anna
Published: October 2024

Introduction

Mobility, defined as active, controlled, multi-joint flexibility used in movement, is limited in pregnant women due to problems with low back pain (LBP) and pelvic girdle pain (PGP). The Pregnancy Mobility Index (PMI) is a tool for assessing mobility in relation to LBP/PGP. The lack of a Polish version of the PMI test prompted a transcultural adaptation to the Polish conditions. The aim of the study was to evaluate the measurement properties of the Polish adaptation of the Pregnancy Mobility Index.

Methods

The study involved 121 pregnant women aged 18–44. The translation process was in accordance with the transcultural adaptation design. Reliability was assessed by intraclass correlation coefficient (ICC). Construct validity between the Polish version of the PMI (PMI-PL) and the Physical Activity Pregnancy Questionnaire (PPAQ-PL) was assessed by Spearman’s rank correlation coefficient.

Results

The transcultural adaptation of the PMI test into Polish was satisfactory, with high internal consistency (Cronbach’s alpha = 0.97–0.98, ICC = 0.989). Statistically significant inverse proportional correlations were found for total PA, total PA (light and above), light PA, moderate PA, and vigorous PA in the construct validity analysis between PMI-PL and PPAQ-PL.

Discussion

The Polish version of the PMI is a reliable instrument. The introduction of a questionnaire with a classification system will make it easier for health professionals to monitor the health status of pregnant women and encourage them to engage in physical activity appropriate for their current level of mobility.
The relationship between stress, anxiety and eating behavior among Chinese students: a cross-sectional study
Authors: Chai Yulin , Fu Guoqi , Liu Yanxu , Song Qi , Xue Cailing , Luo Sheng
Published: October 2024

Background

The expansion of higher education and the growing number of college students have led to increased awareness of mental health issues such as stress, anxiety, and eating disorders. In China, the educational system and cultural expectations contribute to the stress experienced by college students. This study aims to clarify the role of anxiety as a mediator in the relationship between stress and eating behaviors among Chinese college students.

Methods

This study utilized data from the 2021 Psychology and Behavior Investigation of Chinese Residents, which included 1,672 college students under the age of 25. The analysis methods comprised descriptive statistics, t-tests, Pearson correlation analyses, and mediation effect analysis.

Results

The findings indicate that Chinese college students experience high levels of stress, with long-term stress slightly exceeding short-term stress. Both types of stress were positively correlated with increased anxiety and the adoption of unhealthy eating behaviors. Anxiety was identified as a significant mediator, accounting for 28.3% of the relationship between long-term stress and eating behavior (95% CI = 0.058–0.183). The mediation effect of short-term stress on eating behavior through anxiety was also significant, explaining 61.4% of the total effect (95% CI = 0.185–0.327).

Conclusion

The study underscores the importance of stress management and mental health services for college students. It recommends a comprehensive approach to reducing external pressures, managing anxiety, and promoting healthy eating behaviors among college students. Suggestions include expanding employment opportunities, providing career guidance, enhancing campus and societal support for holistic development, strengthening mental health services, leveraging artificial intelligence technologies, educating on healthy lifestyles, and implementing targeted health promotion programs.
Factors associated with therapy non-completion for children with problematic sexual behaviors
Authors: Pitre Camille , Daignault Isabelle , Chouinard Thivierge Stéphanie , Tourigny Marc
Published: October 2024

Introduction

Children with problematic sexual behaviors (PSBs) can benefit, along with their parents or caregivers, from specialized therapeutic services to limit the manifestation of these behaviors. However, for some families, mobilization for therapy represents a significant challenge since a considerable proportion do not complete the therapy intended for them. The present study aims to identify the factors associated with therapy completion, thus allowing a deeper understanding of how to support children and more broadly families to complete their therapeutic process.

Methodology

The sample consists of 67 caregiver-child dyads referred to a specialized Center offering PSBs-focused cognitive behavioral therapy, actively involving the caregiver. Standardized questionnaires were administered to children and their caregiver before and after the therapy.

Results

While non-completers represent 31% of our sample, they present very similar profiles to completers in terms of socio-demographic characteristics, behavior problems and symptoms. However, they appear to differ regarding living situations and coping mechanisms. Results show that children who complete therapy are more likely to live in a placement situation, compared to non-completers. Children who completed therapy also report using more coping strategies that aim toward getting social support and less distancing coping strategies than non-completers. Non completers also reported feeling less maternal support compared to completers.

Discussion

Results underline the importance of implementing mobilization efforts for families with children with PSBs, along with a focus on developing efficient coping mechanisms.
Satisfaction analysis of 5G remote ultrasound robot for diagnostics based on a structural equation model
Authors: Han Zhi-Li , Lei Yu-Meng , Yu Jing , Lei Bing-Song , Ye Hua-Rong , Zhang Ge
Published: October 2024

Objectives

With the increasing application of 5G remote ultrasound robots in healthcare, robust methods are in critical demand to assess participant satisfaction and identify its influencing factors. At present, there is limited empirical research on multi-parametric and multidimensional satisfaction evaluation of participants with 5G remote ultrasound robot examination. Previous studies have demonstrated that structural equation modeling (SEM) effectively integrates various statistical techniques to examine the relationships among multiple variables. Therefore, this study aimed to evaluate the satisfaction of participants with 5G remote ultrasound robot examination and its influencing factors using SEM.

Methods

Between April and June 2022, 213 participants from Wuhan Automobile Manufacturing Company underwent remote ultrasound examinations using the MGIUS-R3 remote ultrasound robot system. After these examinations, the participants evaluated the performance of the 5G remote ultrasound robot based on their personal experiences and emotional responses. They completed a satisfaction survey using a self-developed questionnaire, which included 19 items across five dimensions: examination efficiency, examination perception, communication perception, value perception, and examination willingness. A SEM was established to assess the satisfaction of participants with the 5G remote ultrasound robot examinations and the influencing factors.

Results

A total of 201 valid questionnaires were collected. The overall satisfaction of participants with the 5G remote ultrasound robot examination was 45.43 ± 11.60, with 169 participants (84%) expressing satisfaction. In the path hypothesis relationship test, the dimensions of examination efficiency, examination perception, communication perception, and value perception had positive effects on satisfaction, with standardized path coefficients of 0.168, 0.170, 0.175, and 0.191. Satisfaction had a direct positive effect on examination willingness, with a standardized path coefficient of 0.260. Significant differences were observed across different educational levels in the dimensions of examination perception, communication perception, value perception, and examination willingness. Participants with different body mass indices also showed significant differences in examination perception; all p-values were less than 0.05.

Conclusion

In this study, value perception was identified as the most significant factor influencing satisfaction. It could be improved by enhancing participants’ understanding of the accuracy and safety of 5G remote ultrasound robot examinations. This enhances satisfaction and the willingness to undergo examinations. Such improvements not only facilitate the widespread adoption of this technology but also promote the development of telemedicine services.
Multilevel survival analysis of the age at first birth among women in Ethiopia
Authors: Hussen Nuru Mohammed , Arega Gezachew Gebeyehu , Shibeshi Abdu Hailu , Habtie Getnet Mamo , Kassa Tigabu Hailu , Getaneh Arge Kassaye
Published: October 2024

Introduction

The age at first birth refers to the age at which a woman has her first child. It can significantly influence the demographic behavior of women and the general community. Moreover, teenage childbearing is a serious public health and social problem. The main objective of this study was to identify factors associated with age at first birth among women in Ethiopia.

Methods

Secondary data on women were obtained from the 2019 Ethiopia Mini Demographic and Health Survey (EMDHS). These population-based cross-sectional data were downloaded from the Measure Demographic and Health Survey website (http://www.measuredhs.com). The study included a random sample of 8,885 women aged 15–49 years from 305 enumeration areas. A multilevel survival analysis was employed to identify the factors associated with teenage childbearing among women in Ethiopia.

Results

The majority (67.7%) of randomly sampled women were subjected to teenage childbearing. Women being rural dwellers [hazard ratio (HR) = 1.27, 95% CI: 1.05, 1.54]; women from middle-income families (HR = 1.43, 95% CI: 1.18, 1.74); and women from higher-income families (HR = 1.40, 95% CI: 1.15, 1.70) were associated with a higher risk of teenage childbearing. Conversely, contraception method users (HR = 0.87, 95% CI: 0.77, 0.99), Muslims (HR = 0.75, 95% CI: 0.64, 0.89), Orthodoxes (HR = 0.68, 95% CI: 0.57, 0.80), women with secondary education (HR = 0.53, 95% CI: 0.43, 0.65), women with higher education (HR = 0.28 (95% CI: 0.22, 0.37), and the higher age of household head (HR = 0.99, 95% CI: 0.98, 0.99) were associated with a lower risk of teenage childbearing among women in Ethiopia.

Conclusion

Since the median age of women to have their first child was 18 years old, this study strongly suggests that stakeholders at the federal and regional levels must work closely toward enforcing the legal age of marriage and implementing national adolescents’ and youths’ targeted sexual and reproductive health programs.
Exploring the factors of enabling environments for business investment projects in rural communities: stakeholders’ perspectives
Authors: Shongwe Mcolisi Austine , Lukhele Themba Mfanafuthi , Zulu Hlengiwe Patronella
Published: October 2024

In recent years, the local economic development (LED) planning paradigm has gained widespread acceptance worldwide as a locality-based response to the challenges posed by globalization, devolution, and local-level opportunities and challenges. Noticeably, governments in the Global South are seen to be supporting linkage policies that directly couple profitable growth and investment with redistribution and community development in rural-based localities. To attract potential investors to circulate more resources within the local rural communities, local governments must ensure that the local investment climate (LIC) is functional for business investment. Unlike in urban areas, rural localities, by their nature of periphery location from economic development nodes, prospective business investment projects (BIPs) are often faced with delays and uncertainty. This is mainly because the factors underlying the enabling environments for business investment in rural localities are poorly understood and based on speculation. Against this backdrop, this study therefore set out to explore and unveil the key factors that are fundamental for ensuring a conducive and functional local investment climate (LIC) in rural communities. Through a qualitative case study approach with the application of a conventional content analysis method, performed with coding methods, the study unveiled five key factors presented in a thematic approach. Namely, market and customer needs; government and regulatory support; access to infrastructure and services; land availability and zoning; and participatory community engagement. Understanding these fundamental factors that underpin conducive and operational investment environments is important for viable business decision-making in the feasibility study of investment projects toward LED in rural communities.