bluuebunny/crossref_metadata_2025 huggingface dataset:
Between Private and Public: AIDS, Health Care Capitalism, and the Politics of Respectability in 1980s America
Authors: BELL JONATHAN
Published: May 2018

The AIDS crisis in the US in the 1980s radically transformed the relationship between sexual minorities and capitalism. Opportunistic infections given free rein in human bodies by HIV rendered employees visible to employers and to health care providers as an economic risk, and set the stage for battles between health capitalists, politicians, and AIDS activists over access to health care. Health capitalism in 1980s America was both an arena of integration of queer Americans into mainstream society and also a political cul-de-sac, blunting the radical possibilities of sexual politics that were alive in the years before the AIDS crisis. In this article I focus on activist groups, primarily ACT UP, Gay Men's Health Crisis, National Gay Rights Advocates, and National Gay and Lesbian Task Force, and the liberal politicians who led legislative battles at federal and state level to force the health care system to respond to AIDS. In shifting our gaze from the Reagan administration and the religious right as the primary foils to AIDS activism, we can gain new insights into the direction of liberal politics in an era of supposed conservative ascendancy. An understanding of how AIDS activists and their allies negotiated questions of health access suggests that health care activism was in part a marker of class privilege, as gay activists and liberal Democrats openly embraced a medical model for sexual minorities that lifted them above the stigma of a public welfare system and integrated them further into heteronormative capitalism.
Inhibition ofex vivoerythropoiesis by secreted and haemozoin-associatedPlasmodium falciparumproducts
Authors: Boehm Daniela , Healy Lydia , Ring Sarah , Bell Angus
Published: May 2018

It has been estimated that up to a third of global malaria deaths may be attributable to malarial anaemia, with children and pregnant women being those most severely affected. An inefficient erythropoietic response to the destruction of both infected and uninfected erythrocytes in infections withPlasmodiumspp. contributes significantly to the development and persistence of such anaemia. The underlying mechanisms, which could involve both direct inhibition of erythropoiesis by parasite-derived factors and indirect inhibition as a result of modulation of the immune response, remain poorly understood. We found parasite-derived factors in conditioned medium (CM) of blood-stagePlasmodium falciparumand crude isolates of parasite haemozoin directly to inhibit erythropoiesis in anex vivomodel based on peripheral blood haematopoietic stem cells. Erythropoiesis-inhibiting activity was detected in a fraction of CM that was sensitive to heat inactivation and protease digestion. Erythropoiesis was also inhibited by crude parasite haemozoin but not by detergent-treated, heat-inactivated or protease-digested haemozoin. These results suggest that the erythropoiesis-inhibiting activity in both cases is mediated by proteins or protein-containing biomolecules and may offer new leads to the treatment of malarial anaemia.
Development of a sensitive immunochromatographic kit using fluorescent silica nanoparticles for rapid serodiagnosis of amebiasis
Authors: Tachibana Hiroshi , Kakino Azumi , Kazama Makoto , Feng Meng , Asai Satomi , Umezawa Kazuo , Nozaki Tsukasa , Makiuchi Takashi , Kamada Takayuki , Watanabe Hideki , Horiki Noriyuki , Cheng Xunjia , Masuda Gohta
Published: May 2018

We have previously shown that the C-terminal region of the intermediate subunit ofEntamoeba histolyticagalactose- andN-acetyl-D-galactosamine-inhibitable lectin (C-Igl) is a useful antigen for serodiagnosis of amebiasis. An immunochromatographic kit was developed using fluorescent silica nanoparticles coated with C-Igl prepared inEscherichia coli. Samples for examination were added to the freeze-dried particles and then applied to the immunochromatographic device, in which a test line on the membrane was also coated with C-Igl. Fluorescent intensity was measured using a hand-held reader. In an evaluation of the kit using a human monoclonal antibody, the minimum amount of C-Igl specific antibody showing positive results was 100 pg. In the evaluation of serum samples with different antibody titers in indirect immunofluorescent antibody tests in the kit, 20µL of serum was sufficient to obtain positive results at 30 min. Serum samples from symptomatic patients with amebic colitis and amebic liver abscess and those from asymptomaticE. histolytica-cyst carriers showed positive results in the kit. Based on evaluation using sera from healthy controls and patients with other infectious diseases, the sensitivity and specificity of the kit were 100 and 97.6%, respectively. Therefore, we conclude that the newly developed kit is useful for rapid serodiagnosis of amebiasis.
A new pathogen spillover from domestic to wild animals: Plasmodium juxtanucleare infects free-living passerines in Brazil
Authors: Ferreira-Junior Francisco C. , de Angeli Dutra Daniela , Silveira Patrícia , Pacheco Richard Campos , Witter Rute , de Souza Ramos Dirceu Guilherme , Pacheco M. Andreína , Escalante Ananias A. , Braga Érika M.
Published: May 2018

Habitat modification may facilitate the emergence of novel pathogens, and the expansion of agricultural frontiers make domestic animals important sources of pathogen spillover to wild animals. We demonstrate for the first time that Plasmodium juxtanucleare, a widespread parasite from domestic chickens, naturally infects free-living passerines. We sampled 68 wild birds within and at the border of conservation units in central Brazil composed by Cerrado, a highly threatened biome. Seven out of 10 passerines captured in the limits of a protected area with a small farm were infected by P. juxtanucleare as was confirmed by sequencing a fragment of the parasite's cytochrome b. Blood smears from these positive passerines presented trophozoites, meronts and gametocytes compatible with P. juxtanucleare, meaning these birds are competent hosts for this parasite. After these intriguing results, we sampled 30 backyard chickens managed at the area where P. juxtanucleare-infected passerines were captured, revealing one chicken infected by the same parasite lineage. We sequenced the almost complete mitochondrial genome from all positive passerines, revealing that Brazilian and Asian parasites are closely related. P. juxtanucleare can be lethal to non-domestic hosts under captive and rehabilitation conditions, suggesting that this novel spillover may pose a real threat to wild birds.
The philosophy offilioque
Authors: EFFINGHAM NIKK
Published: May 2018

This article offers a model of the Trinity dealing with various objections to thefilioqueclause. I deal with three worries: the problem of double procession; the problem of the Father's omnipotence; worries about the Spirit's subordination. The model has two main commitments: (i) relations like proceeding, begetting, generation, etc. are causal relations; (ii) each Divine Person is caused by the other two Divine Persons. The model also allows for the Father's elevation over and above the Spirit and the Son. I end by discussing some problems for this revisionary scheme.1
Exploiting lattice structures in shape grammar implementations
Authors: Chau Hau Hing , McKay Alison , Earl Christopher F. , Behera Amar Kumar , de Pennington Alan
Published: May 2018

The ability to work with ambiguity and compute new designs based on both defined and emergent shapes are unique advantages of shape grammars. Realizing these benefits in design practice requires the implementation of general purpose shape grammar interpreters that support: (a) the detection of arbitrary subshapes in arbitrary shapes and (b) the application of shape rules that use these subshapes to create new shapes. The complexity of currently available interpreters results from their combination of shape computation (for subshape detection and the application of rules) with computational geometry (for the geometric operations need to generate new shapes). This paper proposes a shape grammar implementation method for three-dimensional circular arcs represented as rational quadratic Bézier curves based on lattice theory that reduces this complexity by separating steps in a shape computation process from the geometrical operations associated with specific grammars and shapes. The method is demonstrated through application to two well-known shape grammars: Stiny's triangles grammar and Jowers and Earl's trefoil grammar. A prototype computer implementation of an interpreter kernel has been built and its application to both grammars is presented. The use of Bézier curves in three dimensions opens the possibility to extend shape grammar implementations to cover the wider range of applications that are needed before practical implementations for use in real life product design and development processes become feasible.
Efficient probabilistic grammar induction for design
Authors: Whiting Mark E. , Cagan Jonathan , LeDuc Philip
Published: May 2018

The use of grammars in design and analysis has been set back by the lack of automated ways to induce them from arbitrarily structured datasets. Machine translation methods provide a construct for inducing grammars from coded data which have been extended to be used for design through pre-coded design data. This work introduces a four-step process for inducing grammars from un-coded structured datasets which can constitute a wide variety of data types, including many used in the design. The method includes: (1) extracting objects from the data, (2) forming structures from objects, (3) expanding structures into rules based on frequency, and (4) finding rule similarities that lead to consolidation or abstraction. To evaluate this method, grammars are induced from generated data, architectural layouts and three-dimensional design models to demonstrate that this method offers usable grammars automatically which are functionally similar to grammars produced by hand.
Shape grammars as design tools: an implementation of a multipurpose chair grammar
Authors: Garcia Sara , Menezes Leitão António
Published: May 2018

This paper presents a multipurpose chair grammar and its implementation in the design toolChairDNA. This tool is oriented for the exploration of design alternatives in the early concept phase of the chair design process. This work addresses two shortcomings within the research area of shape grammars (SGs), namely, the lack of implementation of SGs applied to design domains, and the lack of practical applications in real-life design scenarios. To address these problems, a methodology is proposed for the implementation of a SG (more specifically, a set grammar) into a tool, comprising the translation of the grammar into user-interface elements oriented for design practitioners. By using the proposed tool, the user can add/delete chair components and edit shape parameters, while visualizing the effects on a three-dimensional digital model presented in a variety of CAD applications. Compared with other SG implementations, ChairDNA uses an approach that keeps under control the combinatorial explosion of rule applications, which simplifies the use of the tool by designers that do not have experience in SGs. The generative potential of the tool is demonstrated by generating chairs of different types, and its usability and utility in aiding the designer are evaluated by design students and design practitioners.
Outcomes associated with Clostridium difficile infection in patients with chronic liver disease
Authors: Dotson Kierra M. , Aitken Samuel L. , Sofjan Amelia K. , Shah Dhara N. , Aparasu Rajender R. , Garey Kevin W.
Published: May 2018

Patients with chronic liver disease (CLD) have frequent exposure to Clostridium difficile infection (CDI) risk factors but the incidence and aetiology of CDI on this population is poorly understood. The aim of this study was to assess the incidence, disease presentation and outcomes of CDI in patients with underlying CLD. The Health Care and Utilization Project National Inpatient Sample (HCUP-NIS) 2009 dataset was used to identify patients with CLD who developed CDI along with matched non-CLD patients with CDI. Using the NIS dataset, the incidence rate of CDI was 189.4/10 000 discharges in CLD patients vs. 83.7/10 000 discharges in the non-CLD matched cohort (P < 0.001). Compared with non-CLD, comorbidity-matched controls with CDI, CLD patients with CDI had higher likelihood of in-hospital mortality (8.8% vs. 18.6%, P < 0.001), increased length of stay by 1.19 days (P < 0.001) and increased total costs by $8632 (P < 0.001). In separate analyses using a tertiary case database of hospitalised patients in Houston, Texas (2006–2016) with CLD and CDI (n = 41) compared with patients with CDI but not CLD (n = 111), CLD patients had significantly higher Charlson comorbidity index (P < 0.0001) but similar risk factors for CDI and CDI-related disease presentation compared with non-CLD patients. In conclusion, CDI-related risk factors were almost universally present in the CLD population. CDI resulted in worse outcomes in this population.
EARLY EXEGETICAL PRACTICE ON AVICENNA'S ŠIFĀʾ: FAḪR AL-DĪN AL-RĀZĪ’S MARGINALIA TO LOGIC
Authors: Di Vincenzo Silvia
Published: May 2018

Nine manuscripts preserving Avicenna's Kitāb al-Šifāʾ share a set of identical marginal glosses to the section of Logic. One of these manuscripts reports, at the end of each of the glosses, a certificate of transmission ascribing them to the theologian and philosopher Faḫr al-Dīn al-Rāzī (d. 606H/1210), which provides some material evidence of the existence of a flourishing exegetical activity on the Kitāb al-Šifāʾ during the twelfth-thirteenth century, in spite of the apparent lack of commentaries on the text in that period. The present paper provides an edition of the so far unknown ḥāšiyāt to Avicenna's Kitāb al-Šifāʾ by al-Rāzī, with an attempt at reconstructing their tradition and contextualizing them within al-Rāzī’s exegetical and teaching activity.
Outpatient pharmacologic weaning for neonatal abstinence syndrome: a systematic review
Authors: Murphy-Oikonen Jodie , McQueen Karen
Published: May 2018

Aim

The purpose of this systematic review was to assess the literature regarding the effectiveness and safety of outpatient pharmacologic weaning for infants with neonatal abstinence syndrome (NAS).

Background

NAS is a multi-system disorder observed in infants experiencing withdrawal from opioid exposure in utero. Infants requiring pharmacologic treatment to manage withdrawal, traditionally receive treatment as a hospital inpatient resulting in lengthy hospitalization periods. However, there is evidence to suggest that some healthcare institutions are continuing outpatient pharmacologic weaning for select infants in a home environment. As there is no standard of care to guide outpatient weaning, assessment of the safety and effectiveness of this approach is warranted.

Method

A systematic review of outpatient weaning for infants with NAS was conducted using the electronic databases PubMed, Nursing and Allied Health, CINAHL, Evidence-Based Medicine, Web of Science, Medline, and PsychINFO. Studies were eligible for inclusion in the review if they fulfilled the following criteria: (1) reported original data on outcomes related to the effectiveness or safety of outpatient weaning for infants with NAS, (2) infants were discharged from hospital primarily receiving opioid pharmacologic treatment for NAS, (3) the method included quantitative designs that included an inpatient comparison group, and (4) articles were published in English in a peer-reviewed journal.

Findings

The search identified 154 studies, of which 18 provided information related to NAS and outpatient weaning. After reviewing the remaining full-text studies, six studies met all inclusion and exclusion criteria. All studies identified that outpatient weaning for select infants was associated with shorter hospitalization compared with infants weaned in-hospital only and may be potentially effective in reducing associated healthcare costs. However, duration of pharmacologic treatment was longer in the outpatient weaning groups in the majority of the studies. Furthermore, adverse events were rare and compliance to follow-up treatment was high among those who received outpatient weaning.
The Reciprocal Translation Proviso: An Alternative Approach to Public Reason
Authors: Tyler George
Published: May 2018

The role of religion in politics is problematic for liberal legitimacy. Religion is often restrained by a public reason requirement, but this creates cognitive burdens that asymmetrically impact religious citizens creating unequal barriers to accessing the political system, which is itself problematic for liberal legitimacy. Habermas’ institutional translation proviso balances the competing concerns of liberal legitimacy, which aims to offset the asymmetry disadvantaging religious citizens. This paper analyzes the problem and Habermas’ solution. It concludes that Habermas does not alleviate the asymmetry created by the public reason requirement to the greatest extent possible and so does not equalize the barriers to accessing the political system as much as he might. The reciprocal translation proviso provides an alternative that balances the competing components of liberal legitimacy more fully and alleviates the asymmetry and inequality of barriers to political access to the greatest extent possible while preserving the public reason requirement.
Modeling the Impact of Harvest Weed Seed Control on Herbicide-Resistance Evolution
Authors: Somerville Gayle J. , Powles Stephen B. , Walsh Michael J. , Renton Michael
Published: May 2018

Harvest weed seed control (HWSC) techniques have been implemented in Australian cropping systems to target and reduce the number of weed seeds entering the seedbank and thereby reduce the number of problematic weeds emerging in subsequent years to infest subsequent crops. However, the influence of HWSC on ameliorating herbicide-resistance (HR) evolution has not been investigated. This research used integrated spatial modeling to examine how the frequency and efficacy of HWSC affected the evolution of resistance to initially effective herbicides. Herbicides were, in all cases, better protected from future resistance evolution when their use was combined with annual HWSC. Outbreaks of multiple HR were very unlikely to occur and were nearly always eliminated by adding annual, efficient HWSC. The efficacy of the HWSC was important, with greater reductions in the number of resistance genes achieved with higher-efficacy HWSC. Annual HWSC was necessary to protect sequences of lower-efficacy herbicides, but HWSC could still protect herbicides if it was used less often than once per year, when the HWSC and the herbicides were highly effective. Our results highlight the potential benefits of combining HWSC with effective herbicides for controlling weed populations and reducing the future evolution of HR.
Differential Performance of Professional Dancers to the Music Apperception Test and the Thematic Apperception Test
Authors: van den Daele Leland , Yates Ashley , Rae Jenkins Sharon
Published: May 2018

Abstract. This project compared the relative performance of professional dancers and nondancers on the Music Apperception Test (MAT; van den Daele, 2014 ), then compared dancers’ performance on the MAT with that on the Thematic Apperception Test (TAT; Murray, 1943 ). The MAT asks respondents to “tell a story to the music” in compositions written to represent basic emotions. Dancers had significantly shorter response latency and were more fluent in storytelling than a comparison group matched for gender and age. Criterion-based evaluation of dancers’ narratives found narrative emotion consistent with music written to portray the emotion, with the majority integrating movement, sensation, and imagery. Approximately half the dancers were significantly more fluent on the MAT than the TAT, while the other half were significantly more fluent on the TAT than the MAT. Dancers who were more fluent on the MAT had a higher proportion of narratives that integrated movement and imagery compared with those more fluent on the TAT. The results were interpreted as consistent with differences observed in neurological studies of auditory and visual processing, educational studies of modality preference, and the cognitive style literature. The MAT provides an assessment tool to complement visually based performance tests in personality appraisal.
SCZI or PTI – Schizophrenia or Psychosis?
Authors: Campo† Vera
Published: May 2018

Abstract. This paper attempts to illustrate the usefulness of therapy follow-up studies with the Rorschach, based on a particularly striking and difficult protocol (including Structural Summary 1 and 2), in which the two indexes pointed to either schizophrenia (Schizophrenia Index, SCZI) or a psychotic episode (Perceptual-Thinking Index, PTI) in an adolescent whose later development was distinctly positive. Implications of the interpretive process are discussed, of the use of both indexes in favor of the PTI, as well as of the danger of depending on single indexes or of using the Rorschach for psychiatric diagnosis.
PyBacktrack 1.0: A Tool for Reconstructing Paleobathymetry on Oceanic and Continental Crust
Authors: Müller R. D. , Cannon J. , Williams S. , Dutkiewicz A.
Published: May 2018

The pyBacktrack software package allows the backtracking of the paleo‐water depth of ocean drill sites, providing a framework for reconstructing the accumulation history of sediment components through time. The software incorporates the effects of decompaction of common marine lithologies and allows backtracking of sites on both oceanic and continental crust. Backtracking on ocean crust is based on a user‐selected lithospheric age‐depth model and the present‐day unloaded basement depth. Backtracking on continental crust is based on syn‐rift and post‐rift subsidence that is modeled using the total sediment thickness at the site and the timing of the transition from rifting to thermal subsidence. On sites that did not penetrate basement, the age‐coded stratigraphy is supplemented with a synthetic stratigraphic section that represents the undrilled section, whose thickness is estimated using a global sediment thickness map. This is essential for estimating the decompacted thickness of the total sedimentary section, and thus bathymetry, through time. PyBacktrack further allows the consideration of the effects of mantle‐convection driven dynamic topography on paleo‐water depth. The user can select one of the dynamic topography models bundled with pyBacktrack or add other models. PyBacktrack runs on all platforms with a Python 2.7 and a pyGPlates installation and is available via Github.
The Alpine Fault Hangingwall Viewed From Within: Structural Analysis of Ultrasonic Image Logs in the DFDP‐2B Borehole, New Zealand
Authors: Massiot Cécile , Célérier Bernard , Doan Mai‐Linh , Little Tim A. , Townend John , McNamara David D. , Williams Jack , Schmitt Douglas R. , Toy Virginia G. , Sutherland Rupert , Janku‐Capova Lucie , Upton Phaedra , Pezard Philippe A.
Published: May 2018

Ultrasonic image logs acquired in the DFDP‐2B borehole yield the first continuous, subsurface description of the transition from schist to mylonite in the hangingwall of the Alpine Fault, New Zealand, to a depth of 818 m below surface. Three feature sets are delineated. One set, comprising foliation and foliation‐parallel veins and fractures, has a constant orientation. The average dip direction of 145° is subparallel to the dip direction of the Alpine Fault, and the average dip magnitude of 60° is similar to nearby outcrop observations of foliation in the Alpine mylonites that occur immediately above the Alpine Fault. We suggest that this foliation orientation is similar to the Alpine Fault plane at ∼1 km depth in the Whataroa valley. The other two auxiliary feature sets are interpreted as joints based on their morphology and orientation. Subvertical joints with NW‐SE (137°) strike occurring dominantly above ∼500 m are interpreted as being formed during the exhumation and unloading of the Alpine Fault's hangingwall. Gently dipping joints, predominantly observed below ∼500 m, are interpreted as inherited hydrofractures exhumed from their depth of formation. These three fracture sets, combined with subsidiary brecciated fault zones, define the fluid pathways and anisotropic permeability directions. In addition, high topographic relief, which perturbs the stress tensor, likely enhances the slip potential and thus permeability of subvertical fractures below the ridges, and of gently dipping fractures below the valleys. Thus, DFDP‐2B borehole observations support the inference of a large zone of enhanced permeability in the hangingwall of the Alpine Fault.
Downcore Variations of Sedimentary Detrital (238U/232Th) Ratio: Implications on the Use of 230Thxs and 231Paxs to Reconstruct Sediment Flux and Ocean Circulation
Authors: Missiaen L. , Pichat S. , Waelbroeck C. , Douville E. , Bordier L. , Dapoigny A. , Thil F. , Foliot L. , Wacker L.
Published: May 2018

Excess 231Pa and 230Th (231Paxs and 230Thxs) can be used to reconstruct past oceanic sedimentation (230Th‐normalized flux) and circulation changes ((231Pa/230Th)xs,0, hereafter Pa/Th). These quantities are determined by computing the detrital and authigenic contributions from bulk sediment measurement. The method relies on the use of a chosen constant value of the detrital (238U/232Th) activity ratio (hereafter (U/Th)det). In this study, we have extracted the detrital fraction of the sediments from North Atlantic deep‐sea core SU90‐08 (43°03′1N, 30°02′5W, 3,080m) and determined its (U/Th)det value over the last 40 ky. We find that (U/Th)det varied significantly through time with a minimum value of 0.4 during the Holocene and a maximum value of 0.7 during the Last Glacial Maximum (LGM). The sensitivity of sedimentary 230Th‐normalized flux and Pa/Th is tested for our study site and for other North Atlantic sites. We show that the sensitivity is highly dependent on the core location and its terrigenous material supply. The 230Th‐normalized flux and Pa/Th signals are very robust in cores with low detrital contributions, whereas they are very sensitive to (U/Th)det changes in cores with higher detrital contribution. In the latter case, changes in 230Th‐normalized flux and Pa/Th due to the choice of a constant (U/Th)det can largely exceed the uncertainty on the 230Th‐normalized flux and Pa/Th, inducing potential biases in the amplitude and temporal variability of reconstructed sedimentation and ocean circulation changes.
Inert and Adsorptive Tracer Tests for Field Measurement of Flow‐Wetted Surface Area
Authors: Hawkins Adam J. , Becker Matthew W. , Tester Jefferson W.
Published: May 2018

Field tests in a discrete rock fracture validated a combined inert/adsorbing tracer test method to estimate the contact area between fluids circulating through a fracture and the bulk rock matrix (i.e., flow‐wetted surface area, A). Tracer tests and heat injections occurred at a mesoscale well field in Altona, NY. A subhorizontal bedding plane fracture ∼7.6 m below ground surface connects two wells separated by 14.1 m. Recovery of the adsorbing tracer cesium was roughly 72% less than the inert tracer iodide. Using an advection‐dispersion‐reaction model in one‐dimension, the adsorbing/inert tracer method identified substantial flow channelization. These results are consistent with Ground Penetrating Radar (GPR) and thermal sensors. All characterization methods suggest circulating fluids were concentrated in a narrow, 1–2 m wide channel directly connecting the injection and production well. The inert/adsorbing tracer method identified two flow channels with areas of 28 and 80 m2. A one‐dimensional heat transport model predicted production well temperature rises 20.5°C in 6 days, whereas measured temperature rise was 17.6°C. For comparison, two‐dimensional heat transport through a fracture of uniform aperture (i.e., homogeneous permeability) predicted roughly 670 days until production well temperature would rise 17.6°C. This suggests that the use of a fracture of uniform aperture to predict heat transport may drastically overpredict the thermal performance of a geothermal system. In the context of commercial geothermal reservoirs, the results of this study suggest that combined inert/adsorbing tracer tests could predict production well thermal drawdown, leading to improved reservoir monitoring and management.
Satellite Data Archives Reveal Unrecorded Himalayan Floods
Authors: Kornei Katherine
Published: May 2018

Almost 30 years’ worth of Landsat observations created a comprehensive inventory of catastrophic floods caused by glacial lakes bursting through their rock dams.
Marine Volcaniclastic Record of Early Arc Evolution in the Eastern Ritter Range Pendant, Central Sierra Nevada, California
Authors: Barth A. P. , Wooden J. L. , Riggs N. R. , Walker J. D. , Tani K. , Penniston‐Dorland S. C. , Jacobson C. E. , Laughlin J. A. , Hiramatsu R.
Published: May 2018

Marine volcaniclastic rocks in the Sierra Nevada preserve a critical record of silicic magmatism in the early Sierra Nevada volcanic arc, and this magmatic record provides precise minimum age constraints on subduction inception and tectonic evolution of the early Mesozoic Cordilleran convergent margin at this latitude. New zircon Pb/U ages from the Ritter Range pendant and regional correlations indicate arc inception no later than mid‐Triassic time between 37°N and 38°N. The regional first‐order felsic magma eruption rate as recorded by marine volcanic arc rocks was episodic, with distinct pulses of ignimbrite emplacement at ca. 221–216 and 174–167 Ma. Ignimbrites range from dacite to rhyolite in bulk composition, and are petrographically similar to modern arc‐type, monotonous intermediate dacite or phenocryst‐poor, low‐silica rhyolite. Zircon trace element geochemistry indicates that Jurassic silicic melts were consistently Ti‐enriched and light rare earth‐enriched and U‐depleted in comparison to Triassic melts of the juvenile arc, suggesting Jurassic silicic melts were hotter, drier, and derived from distinct lithospheric sources not tapped in the juvenile stage of arc construction. Pulses of ignimbrite deposition were coeval with granodioritic to granitic components of the underlying early Mesozoic Sierra Nevada batholith, suggesting explosive silicic volcanism and batholith construction were closely coupled at 1–2 million‐year time scales.
Seismic Structure of the Upper Mantle Beneath Eastern Asia From Full Waveform Seismic Tomography
Authors: Tao Kai , Grand Stephen P. , Niu Fenglin
Published: May 2018

To better understand the subsurface behavior of subducting slabs and their relation to the tectonic evolution of the overriding plate, we conduct a full waveform inversion on a large data set to determine a high‐resolution seismic model, FWEA18 (Full Waveform inversion of East Asia in 2018), of the upper mantle beneath eastern Asia. FWEA18 reveals sharper, more intense high‐velocity slabs in the upper mantle under the southern Kuril, Japan, and Ryukyu arcs, than previous studies have found. The subducting Pacific plate is imaged as a roughly 100 km thick high‐velocity slab to near 550 km depth indicating relatively little deformation. Stagnation near 600 km depth is observed over horizontal distances of 600 km or less. The Pacific plate we image accounts for roughly 25 Myr of subduction with older slab likely located in the lower mantle. The Philippine plate, subducting beneath the Ryukyu Islands, has a clear termination at about 450 km depth. This may indicate a tearing event in the past or that less Philippine Sea plate has subducted than previously thought. We found a double‐layer high‐velocity anomaly above and below 660 km under the Yellow Sea and eastern coast of North China. This may correspond to parts of the Philippine Sea plate that detached in the past and Pacific plate that have intersected at depth or a complicated behavior of the Pacific plate at that depth. Slow cylindrical anomalies cross the entire upper mantle are imaged beneath major Holocene volcanoes, which are likely upwellings associated with the edges of deep slabs that are entering the lower mantle.
Significant Space Weather Impact on the Escape of Hydrogen From Mars
Authors: Mayyasi Majd , Bhattacharyya Dolon , Clarke John , Catalano Amy , Benna Mehdi , Mahaffy Paul , Thiemann Edward , Lee Christina O. , Deighan Justin , Jain Sonal , Chaffin Michael , Crismani Matteo , McClintock William , Stewart Ian , Holsclaw Greg , Stiepen Arnaud , Montmessin Franck , Schneider Nick , Jakosky Bruce
Published: May 2018

In September 2017, an active region of the Sun produced a series of strong flares and a coronal mass ejection that swept past Mars producing enhanced ionization and heating in the upper atmosphere. Emissions from atmospheric hydrogen Lyman‐α were also enhanced at Mars. Temperatures derived from neutral species scale heights were used in conjunction with the H Lyman‐α observations to simulate the effects of this space weather event on Martian hydrogen properties in the exosphere. It was found that hydrogen abundance in the upper atmosphere decreased by ~25% and that the H escape rate increased by a factor of 5, mainly through an increase in upper atmospheric temperature. This significant escape rate variation is comparable to seasonally observed trends but occurred at much shorter timescales. Such solar events would statistically impact extrapolation of Martian water loss over time.
Leukaemic alterations of IKZF1 prime stemness and malignancy programs in human lymphocytes
Authors: Li Zhen , Li Shui-Ping , Li Ruo-Yan , Zhu Hua , Liu Xia , Guo Xiao-Lin , Mu Li-Li , Cai Jie-Jing , Bai Fan , Chen Guo-Qiang , Hong Deng-Li
Published: May 2018

Somatic cells acquire stem cell-like properties during cancerous transformation; however, mechanisms through which committed cells develop stemness and malignancy remain largely unknown. Here we uncovered upregulated stem cell program in leukaemic lymphoblasts of patients withIKZF1alterations by analysing the archived gene-expression profiling datasets. We then used a frequentIKZF1deletion, IK6, as a model via transduction into human primitive haematopoietic cells, followed by xenotransplantation in mice. Immunophenotypically defined stem, pro-B, and immature/mature (IM/M)-B cells were collected from primary recipients for functional assay and transcriptome profiling. Successful reconstitution in secondary recipient mice revealed the stemness of IK6+pro-B and IM/M-B cells. Upregulated stemness and malignancy programs in IK6+cells confirmed IK6 effects. Interestingly, these programs corresponded to distinct canonical pathways. Remarkably, the pathway profile mapped in the modelled cells well mirrored that in patients’ leukaemic cells; therefore, our study provides a seminal insight into the cancerous reprogramming of somatic cells.
Diffusion markers of dendritic density and arborization in gray matter predict differences in intelligence
Authors: Genç Erhan , Fraenz Christoph , Schlüter Caroline , Friedrich Patrick , Hossiep Rüdiger , Voelkle Manuel C. , Ling Josef M. , Güntürkün Onur , Jung Rex E.
Published: May 2018

Previous research has demonstrated that individuals with higher intelligence are more likely to have larger gray matter volume in brain areas predominantly located in parieto-frontal regions. These findings were usually interpreted to mean that individuals with more cortical brain volume possess more neurons and thus exhibit more computational capacity during reasoning. In addition, neuroimaging studies have shown that intelligent individuals, despite their larger brains, tend to exhibit lower rates of brain activity during reasoning. However, the microstructural architecture underlying both observations remains unclear. By combining advanced multi-shell diffusion tensor imaging with a culture-fair matrix-reasoning test, we found that higher intelligence in healthy individuals is related to lower values of dendritic density and arborization. These results suggest that the neuronal circuitry associated with higher intelligence is organized in a sparse and efficient manner, fostering more directed information processing and less cortical activity during reasoning.
Functionalized boron nitride membranes with ultrafast solvent transport performance for molecular separation
Authors: Chen Cheng , Wang Jiemin , Liu Dan , Yang Chen , Liu Yuchen , Ruoff Rodney S. , Lei Weiwei
Published: May 2018

Pressure-driven, superfast organic solvent filtration membranes have significant practical applications. An excellent filtration membrane should exhibit high selectivity and permeation in aqueous and organic solvents to meet increasing industrial demand. Here, we report an amino functionalized boron nitride (FBN) based filtration membrane with a nanochannel network for molecular separation and permeation. This membrane is highly stable in water and in several organic solvents and shows high transport performance for solvents depending on the membranes’ thickness. In addition, the FBN membrane is applicable for solute screening in water as well as in organic solvents. More importantly, the FBN membranes are very stable in acidic, alkaline and oxidative media for up to one month. The fast-flow rate and good separation performance of the FBN membranes can be attributed to their stable networks of nanochannels and thin laminar structure, which provide the membranes with beneficial properties for practical separation and purification processes.
Highly sensitive integrated flexible tactile sensors with piezoresistive Ge
2
Sb2Te5 thin films
Authors: Wang Zhiguang , Dong Cunzheng , Wang Xinjun , Li Menghui , Nan Tianxiang , Liang Xianfeng , Chen Huaihao , Wei Yuyi , Zhou Haomiao , Zaeimbashi Mohsen , Cash Syd , Sun Nian-Xiang
Published: May 2018

Flexible tactile sensor has been extensively investigated as a key component for emerging electronics applications such as robotics, wearable devices, computer hardware, and security systems. Tactile sensors based on various one-dimensional materials have been widely explored. However, precise control of the direction and distribution of these nanomaterials remains a great challenge, and it has been difficult to scale down the device. Here, we introduce highly sensitive integrated flexible tactile sensors based on uniform phase-change Ge2Sb2Te5 (GST) thin films that can scale device size down, at least, to micrometer range. Significant piezoresistive effect has been observed in GST-based sensors, showing a giant gauge factor of 338. A proof of concept 5 × 5 sensor array functioning as a touch panel has been demonstrated. Also, the flexible GST tactile sensor has been utilized for monitoring of radial artery pulse. In addition to the well-known tunable electrical and optical properties, the piezoresistive GST films provide a versatile platform for the integration of sensing, recording, and displaying functions.
Publisher Correction: Co-expression network analysis of toxin-antitoxin loci in Mycobacterium tuberculosis reveals key modulators of cellular stress
Authors: Gupta Amita , Venkataraman Balaji , Vasudevan Madavan , Bankar Kiran Gopinath
Published: May 2018

A correction to this article has been published and is linked from the HTML and PDF version of this paper. The error has been fixed in the paper.
Author Correction: Protein corona of airborne nanoscale PM2.5 induces aberrant proliferation of human lung fibroblasts based on a 3D organotypic culture
Authors: Li Yan , Wang Pengcheng , Hu Chuanlin , Wang Kun , Chang Qing , Liu Lieju , Han Zhenggang , Shao Yang , Zhai Ying , Zuo Zhengyu , Mak Michael , Gong Zhiyong , Wu Yang
Published: May 2018

A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper.
Publisher Correction: Valproic Acid Sensitizes Hepatocellular Carcinoma Cells to Proton Therapy by Suppressing NRF2 Activation
Authors: Yu Jeong Il , Choi Changhoon , Shin Sung-Won , Son Arang , Lee Ga-Haeng , Kim Shin-Yeong , Park Hee Chul
Published: May 2018

A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper.
Stable isotopes in water vapor and rainwater over Indian sector of Southern Ocean and estimation of fraction of recycled moisture
Authors: Rahul P. , Prasanna K. , Ghosh Prosenjit , Anilkumar N. , Yoshimura Kei
Published: May 2018

Stable Hydrogen and Oxygen isotopic composition of water vapor, rainwater and surface seawater show a distinct trend across the latitude over the Southern Indian Ocean. Our observations on isotopic composition of surface seawater, water vapor and rainwater across a transect covering the tropical Indian Ocean to the regions of the Southern Ocean showed a strong latitudinal dependency; characterized by the zonal process of evaporation and precipitation. The sampling points were spread across diverse zones of SST, wind speed and rainfall regimes. The observed physical parameters such as sea surface temperature, wind speed and relative humidity over the oceanic regions were used in a box model calculation across the latitudes to predict the isotopic composition of water vapor under equilibrium and kinetic conditions, and compared with results from isotope enabled global spectral model. Further, we obtained the average fraction of recycled moisture across the oceanic transect latitudes as 13.4 ± 7.7%. The values of recycled fraction were maximum at the vicinity of the Inter Tropical Convergence Zone (ITCZ), while the minimum values were recorded over the region of subsidence and evaporation, at the Northern and Southern latitudes of the ITCZ. These estimates are consistent with the earlier reported recyling values.
Resveratrol significantly improves the fertilisation capacity of bovine sex-sorted semen by inhibiting apoptosis and lipid peroxidation
Authors: Li Chong-Yang , Zhao Ya-Han , Hao Hai-Sheng , Wang Hao-Yu , Huang Jin-Ming , Yan Chang-Liang , Du Wei-Hua , Pang Yun-Wei , Zhang Pei-Pei , Liu Yan , Zhu Hua-Bin , Zhao Xue-Ming
Published: May 2018

The aim of this study was to test the effects of five different concentrations (0, 10−3, 10−4, 10−5, and 10−6 M) of resveratrol (Res) supplementation in bull sperm washing and fertilisation medium on levels of reactive oxygen species (ROS), phosphatidylserine (PS) externalisation, mitochondrial membrane potential (Δψm), ATP and malondialdehyde (MDA), acrosomal integrity, blastocyst rate, and blastocyst quality after in vitro fertilisation (IVF). The results for sex-sorted sperm from three bulls showed: (1) ROS and MDA levels in 10−3 M and 10−4 M Res groups were significantly lower than those of controls (P < 0.05); (2) the percentage of viable sperm, percentage of sperm with high Δψm, and the ATP content in 10−3 M and 10−4 M Res groups were significantly higher than those of controls (P < 0.05); (3) the percentage of viable sperm with acrosomal integrity, and the blastocyst percentage and quality of the 10−4 M Res group were significantly higher than those of controls (P < 0.05). In conclusion, 10−4 M Res supplementation in washing and fertilisation medium of sex-sorted bull sperm significantly decreased ROS, PS externalisation, and MDA, and protected mitochondrial function and acrosomal integrity, thereby increasing blastocyst percentage and quality following IVF.
Submarine canyons represent an essential habitat network for krill hotspots in a Large Marine Ecosystem
Authors: Santora Jarrod A. , Zeno Ramona , Dorman Jeffrey G. , Sydeman William J.
Published: May 2018

Submarine canyon systems are ubiquitous features of marine ecosystems, known to support high levels of biodiversity. Canyons may be important to benthic-pelagic ecosystem coupling, but their role in concentrating plankton and structuring pelagic communities is not well known. We hypothesize that at the scale of a large marine ecosystem, canyons provide a critical habitat network, which maintain energy flow and trophic interactions. We evaluate canyon characteristics relative to the distribution and abundance of krill, critically important prey in the California Current Ecosystem. Using a geological database, we conducted a census of canyon locations, evaluated their dimensions, and quantified functional relationships with krill hotspots (i.e., sites of persistently elevated abundance) derived from hydro-acoustic surveys. We found that 76% of krill hotspots occurred within and adjacent to canyons. Most krill hotspots were associated with large shelf-incising canyons. Krill hotspots and canyon dimensions displayed similar coherence as a function of latitude and indicate a potential regional habitat network. The latitudinal migration of many fish, seabirds and mammals may be enhanced by using this canyon-krill network to maintain foraging opportunities. Biogeographic assessments and predictions of krill and krill-predator distributions under climate change may be improved by accounting for canyons in habitat models.
Space-Wave Routing via Surface Waves Using a Metasurface System
Authors: Achouri Karim , Caloz Christophe
Published: May 2018

We introduce the concept of a metasurface system able to route space waves via surface waves. This concept may be used to laterally shift or modulate the beam width of scattered waves. The system is synthesized based on a momentum transfer approach using phase-gradient metasurfaces. The concept is experimentally verified in an “electromagnetic periscope”. Additionally, we propose two other potential applications namely a beam expander and a multi-wave refractor.
Identification of a flagellar protein implicated in the gravitaxis in the flagellate Euglena gracilis
Authors: Nasir Adeel , Le Bail Aude , Daiker Viktor , Klima Janine , Richter Peter , Lebert Michael
Published: May 2018

Flagellated cells are of great evolutionary importance across animal and plant species. Unlike higher plants, flagellated cells are involved in reproduction of macro-algae as well as in early diverging land plants. Euglena gracilis is an emerging flagellated model organism. The current study reports that a specific calmodulin (CaM2) involved in gravitaxis of E. gracilis interacts with an evolutionary conserved flagellar protein, EgPCDUF4201. The subsequent molecular analysis showed clearly that EgPCDUF4201 is also involved in gravitaxis. We performed subcellular localization of CaM2 using immunoblotting and indirect immunofluorescence. By employing yeast two-hybrid screen, EgPCDUF4201 was identified as an interaction partner of CaM2. The C-terminus of EgPCDUF4201 is responsible for the interaction with CaM2. Silencing of N- and C-terminus of EgPCDUF4201 using RNAi resulted in an impaired gravitaxis. Moreover, indirect immunofluorescence assay showed that EgPCDUF4201 is a flagella associated protein. The current study specifically addressed some important questions regarding the signal transduction chain of gravitaxis in E. gracilis. Besides the fact that it improved the current understanding of gravity sensing mechanisms in E. gracilis, it also gave rise to several interesting research questions regarding the function of the domain of unknown function 4201 in flagellated cells.