bluuebunny/crossref_metadata_2025 huggingface dataset:
Possible Neuroprotective Mechanisms of Physical Exercise in Neurodegeneration
Authors: Mahalakshmi B. , Maurya Nancy , Lee Shin-Da , Bharath Kumar V.
Published: August 2020

Physical exercise (PE) improves physical performance, mental status, general health, and well-being. It does so by affecting many mechanisms at the cellular and molecular level. PE is beneficial for people suffering from neuro-degenerative diseases because it improves the production of neurotrophic factors, neurotransmitters, and hormones. PE promotes neuronal survival and neuroplasticity and also optimizes neuroendocrine and physiological responses to psychosocial and physical stress. PE sensitizes the parasympathetic nervous system (PNS), Autonomic Nervous System (ANS) and central nervous system (CNS) by promoting many processes such as synaptic plasticity, neurogenesis, angiogenesis, and autophagy. Overall, it carries out many protective and preventive activities such as improvements in memory, cognition, sleep and mood; growth of new blood vessels in nervous system; and the reduction of stress, anxiety, neuro-inflammation, and insulin resistance. In the present work, the protective effects of PE were overviewed. Suitable examples from the current research work in this context are also given in the article.
Metastasis Suppressor NME1 Modulates Choice of Double-Strand Break Repair Pathways in Melanoma Cells by Enhancing Alternative NHEJ while Inhibiting NHEJ and HR
Authors: Puts Gemma , Jarrett Stuart , Leonard Mary , Matsangos Nicolette , Snyder Devin , Wang Ying , Vincent Richard , Portney Benjamin , Abbotts Rachel , McLaughlin Lena , Zalzman Michal , Rassool Feyruz , Kaetzel David
Published: August 2020

Reduced NME1 expression in melanoma cell lines, mouse models of melanoma, and melanoma specimens in human patients is associated with increased metastatic activity. Herein, we investigate the role of NME1 in repair of double-stranded breaks (DSBs) and choice of double-strand break repair (DSBR) pathways in melanoma cells. Using chromatin immunoprecipitation, NME1 was shown to be recruited rapidly and directly to DSBs generated by the homing endonuclease I-PpoI. NME1 was recruited to DSBs within 30 min, in concert with recruitment of ataxia-telangiectasia mutated (ATM) protein, an early step in DSBR complex formation, as well as loss of histone 2B. NME1 was detected up to 5 kb from the break site after DSB induction, suggesting a role in extending chromatin reorganization away from the repair site. shRNA-mediated silencing of NME1 expression led to increases in the homologous recombination (HR) and non-homologous end-joining (NHEJ) pathways of double-strand break repair (DSBR), and reduction in the low fidelity, alternative-NHEJ (A-NHEJ) pathway. These findings suggest low expression of NME1 drives DSBR towards higher fidelity pathways, conferring enhanced genomic stability necessary for rapid and error-free proliferation in invasive and metastatic cells. The novel mechanism highlighted in the current study appears likely to impact metastatic potential and therapy-resistance in advanced melanoma and other cancers.
Notching and Pulsatility Index of the Uterine Arteries and Preeclampsia in Twin Pregnancies
Authors: Springer Stephanie , Polterauer Mariella , Stammler-Safar Maria , Zeisler Harald , Leipold Heinz , Worda Christof , Worda Katharina
Published: August 2020

Increased uterine artery Doppler indices have been shown to be associated with preeclampsia and adverse pregnancy outcomes in singleton and twin pregnancies. At 20–22 weeks of gestation, we assessed the use of notching, the highest, lowest, and mean pulsatility index (PI), and the combination of notching and PI of the uterine arteries to screen for preeclampsia. This was done in a cohort of 380 twin pregnancies. The results showed that the combination of notching and the highest PI above the 95th centile of the uterine arteries gives the best screening characteristics for preeclampsia in twin pregnancies. We calculated sensitivities for preeclampsia for notching, highest PI, and the combination of notching and the highest PI of 50%, 45% and 91%, with specificities of 96%, 96% and 93%, respectively. The present findings demonstrate that notching, increased highest PI, and the combination of notching and the highest PI of the uterine arteries is associated with an increased risk of preeclampsia in twin pregnancies. We observed the highest sensitivity and specificity by using the combination of notching and the highest PI of the uterine arteries.
An Improved Danger Sector Model for Identifying the Collision Risk of Encountering Ships
Authors: Liu Zihao , Wu Zhaolin , Zheng Zhongyi
Published: August 2020

In order to avoid collision, ships usually take collision avoidance manoeuvres, such as course alteration. However, the effect of such a manoeuvre is influenced by ship manoeuvrability. This paper proposed an improved danger sector model to identify the collision risk between two encountering ships. The proposed model is improved from the danger sector model, which is based on a course alteration manoeuvre by taking ship manoeuvrability into consideration. To involve ship manoeuvrability in the proposed model, the turning circle of a ship is determined when it calculates the size of the danger sector. For validating the proposed model, the Automatic Identification System (AIS) data in the northern Yellow Sea of China were used to carry out some experiments of different encountering scenarios. The results show that the proposed improved danger sector model can identify the collision risk between two encountering ships effectively and has advantages compared with the original danger sector model. The proposed model can help mariners and maritime surveillance operators have a more accurate and effective assessment of ship collision risk in the water area, which can contribute to the improvement of navigational safety.
Titanium Implants Coated with a Bifunctional Molecule with Antimicrobic Activity: A Rabbit Study
Authors: Scarano Antonio , Carinci Francesco , Orsini Tiziana , Valbonetti Luca , Qorri Erda , Bignozzi Carlo Alberto , Lorusso Felice
Published: August 2020

Background: Various surface treatments have been tested for titanium implants aiming at increasing their surface biocompatibility and their biological characteristics, but also the efficiency of the implant surface will have to be improved to drastically decrease peri-implantite and mucosite. In fact, the peri-implantitis and peri-implant mucositis have a high incidence in clinical practice. The nanofabrication techniques that offer the possibility to achieve the implant surface that reduces bacterial colonization could influence the osteointegration. The aim of this research was to evaluate the bone response to titanium implants coated with a bifunctional molecule with antimicrobic activity consisting of a combination of silver ions covalently bound to titanium dioxide nanoparticles. Methods: A total of 36 implants were inserted into 18 older New Zealand white male rabbits. They had two different surfaces. The implants Control group was characterized by an acid-etched and sandblasted surface treatment, and the Test implants had an acid-etched and sandblasted surface coated with a silver ion covalently bound to titanium dioxide nanoparticles in the solution. Results: No statistically significant difference of the bone density was evidenced between Control and Test implants at two weeks (p-value = 0.623), four weeks (p-value = 0.339), and eight weeks (p-value = 0.461). Moreover, no statistically significant difference of the bone-implant contact percentage was evidenced between Control and Test implants at two weeks (p-value = 0.938), four weeks (p-value = 0.307), and eight weeks (p-value = 0.294). The effectiveness of the present investigation demonstrated no adverse effects on osseointegration, and no statistically significant differences were observed in the bone density and percentage of bone-implant contact between Test and Control implants at all the experimental time points (two, four, and eight weeks). Conclusions: Titanium implants coated with the silver-anatase solution bind very well to the bone and did not have an adverse effect on the bone tissue in a rabbit model. These facts suggest possible clinical applications for the silver composition.
Flexural Behavior of Composite Concrete Slabs Made with Steel and Polypropylene Fibers Reinforced Concrete in the Compression Zone
Authors: Sadowska-Buraczewska Barbara , Szafraniec Małgorzata , Barnat-Hunek Danuta , Łagód Grzegorz
Published: August 2020

The paper presented aimed at examining the effect of a fiber-reinforced concrete layer in the compressed zone on the mechanical properties of composite fiber-reinforced concrete slabs. Steel fibers (SF) and polypropylene fibers (PP) in the amount of 1% in relation to the weight of the concrete mix were used as reinforcement fibers. The mixture compositions were developed for the reference concrete, steel fiber concrete and polypropylene fiber concrete. The mechanical properties of the concrete obtained from the designed mixes such as compressive strength, bending strength, modulus of elasticity and frost resistance were tested. The main research elements, i.e., slabs with a reinforced compression zone in the form of a 30 mm layer of concrete with PP or SF were made and tested. The results obtained were compared with a plate made without a strengthening layer. The bending resistance, load capacity and deflection tests were performed on the slabs. A scheme of crack development during the test and a numerical model for the slab element were also devised. The study showed that the composite slabs with fiber-reinforced concrete with PP in the upper layer achieved 12% higher load capacity, with respect to the reference slabs.
Efficient Removal of Metals from Synthetic and Real Galvanic Zinc–Containing Effluents by Brewer’s Yeast Saccharomyces cerevisiae
Authors: Zinicovscaia Inga , Yushin Nikita , Abdusamadzoda Daler , Grozdov Dmitrii , Shvetsova Margarita
Published: August 2020

The performance of the brewer’s yeast Saccharomyces cerevisiae to remove metal ions from four batch systems, namely Zn(II), Zn(II)-Sr(II)-Cu(II), Zn(II)-Ni(II)-Cu(II), and Zn(II)-Sr(II)-Cu(II)-Ba(II), and one real effluent was evaluated. Yeast biosorption capacity under different pH, temperature, initial zinc concentration, and contact time was investigated. The optimal pH for removal of metal ions present in the analyzed solution (Zn, Cu, Ni, Sr, and Ba) varied from 3.0 to 6.0. The biosorption process for zinc ions in all systems obeys Langmuir adsorption isotherm, and, in some cases, the Freundlich model was applicable as well. The kinetics of metal ions biosorption was described by pseudo-first-order, pseudo-second-order, and Elovich models. Thermodynamic calculations showed that metal biosorption was a spontaneous process. The two-stage sequential scheme of zinc ions removal from real effluent by the addition of different dosages of new sorbent allowed us to achieve a high efficiency of Zn(II) ions removal from the effluent. FTIR revealed that OH, C=C, C=O, C–H, C–N, and NH groups were the main biosorption sites for metal ions.
Influence of Rivet Diameter and Pitch on the Fatigue Performance of Riveted Lap Joints Based on Stress Distribution Analysis
Authors: Liu Jintong , Zhao Anan , Ke Zhenzheng , Zhu Zhendong , Bi Yunbo
Published: August 2020

Interference-fit riveting is one of the most widely used mechanical joining ways in aircraft assembly. The fatigue performance of riveted joints has a significant impact on the service life and reliability of aircraft. In this paper, the fatigue performance of the riveted lap joints with various rivet diameters and pitches are studied based on stress distribution analysis under tensile load. First, a theoretical model of the riveted lap joint under tensile load is developed by using the spring-mass model. The rivet-load stress, bypass stress, and interference stress around the riveted hole are analyzed. Then, the finite element (FE) model of riveted lap joints are established. The influence of rivet diameter and pitch on stress distribution around the riveted hole are discussed. Finally, the fatigue tests are conducted with riveted lap joint specimens to verify the theoretical model and FE results, and a good agreement is observed. Based on the simulation and experimental results, a good combination of structural parameters of the riveted lap joint is found which can optimize the stress distribution around the riveted hole and improve the fatigue life of the riveted lap joint.
Fibroblast-Like-Synoviocytes Mediate Secretion of Pro-Inflammatory Cytokines via ERK and JNK MAPKs in Ti-Particle-Induced Osteolysis
Authors: Sharma Ashish Ranjan , Jagga Supriya , Chakraborty Chiranjib , Lee Sang-Soo
Published: August 2020

Biomaterials are designed to replace and augment living tissues in order to provide functional support to skeletal deformities. However, wear debris produced from the interfaces of metal implants initiates inflammatory bone loss, causing periprosthetic osteolysis. Lately, fibroblast-like synoviocytes (FLS) have been shown to play a role in wear-debris-induced osteolysis. Thus, here we have tried to understand the underlying mechanism of FLS involvement in wear-debris-induced osteolysis. Our results demonstrate that the effects of Ti particle (1:100 cell-to-Ti particle ratio) on FLS can induce Cox-2 expression and activate NFkB signaling. Moreover, the mRNA expression of pro-inflammatory cytokines such as IL-6, IL-8, IL-11, IL-1β, and TNFα was found to be elevated. However, among these pro-inflammatory cytokines, the mRNA and protein levels of only IL-6, IL-1β, and TNFα were found to be significantly higher. Ti particles activated extracellular signal-regulated kinase (ERK) and c-Jun N-terminal kinase (JNK) mitogen-activated protein kinases (MAPKs) as an early response in FLS. Co-inhibition of ERK and JNK signaling pathways by their specific inhibitors (PD9805 and SP600125, respectively) resulted in the suppression of mRNA and protein levels of IL-6, IL-1β, and TNFα in FLS. Taken together, targeting ERK and JNK MAPKs in FLS might provide a therapeutic option for reducing the secretion of bone-resorbing pro-inflammatory cytokines, thus preventing periprosthetic osteolysis.
Effect of Rare Earth on Microstructure and Wear Resistance of In-Situ-Synthesized Mo2FeB2 Ceramics-Reinforced Fe-Based Cladding
Authors: Jin Jun , Sun Junsheng , Wang Weimin , Song Jijun , Xu Hu
Published: August 2020

Mo2FeB2 ceramics-reinforced Fe-based cladding with various rare earth (RE) concentrations were prepared by the carbon arc surfacing process. The effects of RE content on the microstructure, phase composition, hardness and wear resistance of the cladding were systematically discussed. Meanwhile, the area fraction and grain size of Mo2FeB2 phase were exactly measured. Moreover, the refining mechanism of rare earth Y was analyzed. Results revealed that the claddings consisted of Mo2FeB2, FeCr, MoB and CrB. Adding the rare-earth Y decreased the grain sizes of Mo2FeB2 phase. Furthermore, grain-refining effects of Mo2FeB2 phase were significant when the RE content was 2% and hard phases evenly distributed in the cladding. In addition, the maximum microhardness value of claddings was about 1078 HV. The claddings with 2% RE contents had better wear resistance, which was equivalent to a sintered sample.
Si-QD Synthesis for Visible Light Emission, Color Conversion, and Optical Switching
Authors: Cheng Chih-Hsien , Lin Gong-Ru
Published: August 2020

This paper reviews the developing progress on the synthesis of the silicon quantum dots (Si-QDs) via the different methods including electrochemical porous Si, Si ion implantation, and plasma enhanced chemical vapor deposition (PECVD), and exploring their featured applications for light emitting diode (LED), color-converted phosphors, and waveguide switching devices. The characteristic parameters of Si-QD LED via different syntheses are summarized for discussion. At first, the photoluminescence spectra of Si-QD and accompanied defects are analyzed to distinguish from each other. Next, the synthesis of porous Si and the performances of porous Si LED reported from different previous works are compared in detail. Later on, the Si-QD implantation in silicide (SiX) dielectric films developed to solve the instability of porous Si and their electroluminescent performances are also summarized for realizing the effect of host matrix to increase the emission quantum efficiency. As the Si-ion implantation still generates numerous defects in host matrix owing to physical bombardment, the PECVD method has emerged as the main-stream methodology for synthesizing Si-QD in SiX semiconductor or dielectric layer. This method effectively suppresses the structural matrix imperfection so as to enhance the external quantum efficiency of the Si-QD LED. With mature synthesis technology, Si-QD has been comprehensively utilized not only for visible light emission but also for color conversion and optical switching applications in future academia and industry.
Improving Biodegradation of Clofibric Acid by Trametes pubescens through the Design of Experimental Tools
Authors: Ungureanu Claudia Veronica , Favier Lidia , Bahrim Gabriela Elena
Published: August 2020

Clofibric acid (CLF) is the main pharmacologically active metabolite in composition of the pharmaceutical products used for controlling blood lipid content. This xenobiotic compound is highly persistent in the aquatic environment and passes unchanged or poorly transformed in wastewater treatment plants. A white-rot fungal strain of Trametes pubescens was previously selected, for its ability for clofibric acid biodegradation (up to 30%) during cultivation in submerged system under aerobic conditions at an initial CLF concentration of 15 mg L−1. Plackett-Burman design (PBD) and response surface methodology (RSM) were used for experimental planning, mathematical modelling and statistical analysis of data of the biotechnological process of CLF biotransformation by Trametes pubescens fungal strain. After optimization, the capacity of the selected Trametes pubescens strain to degrade CLF was increased by cultivation in a liquid medium containing 3 g·L−1 yeast extract, 15 g·L−1 peptone, 5 g·L−1 glucose and mineral salts, inoculated at 2% (v/v) vegetative inoculum and cultivated at pH 5.5, during 14 days at 25 °C and 135 rpm. In these optimized biotechnological conditions, the CLF biotransformation yield was 60%.
Virtual Screening of FDA-Approved Drugs against LasR of Pseudomonas aeruginosa for Antibiofilm Potential
Authors: Sadiq Suhaib , Rana Nosheen Fatima , Zahid Muhammad Ammar , Zargaham Muhammad Kazim , Tanweer Tahreem , Batool Amna , Naeem Ayesha , Nawaz Afrah , Rizwan-ur-Rehman  , Muneer Zahid , Siddiqi Abdul Rauf
Published: August 2020

Pseudomonas aeruginosa is a Gram-negative pathogenic bacterium that is present commonly in soil and water and is responsible for causing septic shock, pneumonia, urinary tract and gastrointestinal infections, etc. The multi-drug resistance (MDR) phenomenon has increased dramatically in past years and is now considered a major threat globally, so there is an urgent need to develop new strategies to overcome drug resistance by P. aeruginosa. In P. aeruginosa, a major factor of drug resistance is associated to the formation of biofilms by the LasR enzyme, which regulates quorum sensing and has been reported as a new therapeutic target for designing novel antibacterial molecules. In this study, virtual screening and molecular docking were performed against the ligand binding domain (LBD) of LasR by employing a pharmacophore hypothesis for the screening of 2373 FDA-approved compounds to filter top-scoring hit compounds. Six inhibitors out of 2373 compounds were found to have binding affinities close to that of known LasR inhibitors. The binding modes of these compounds to the binding site in LasR-LBD were analyzed to identify the key interactions that contribute to the inhibition of LasR activity. Then, 50 ns simulations of top hit compounds were performed to elucidate the stability of their binding conformations with the LasR-LBD. This study, thus concluded that sulfamerazine showed the highest binding affinity for the LasR-LBD binding pocket exhibiting strong inhibitory binding interactions during molecular dynamics (MD) simulation.
Plants as Sources of Anti-Inflammatory Agents
Authors: Nunes Clara dos Reis , Barreto Arantes Mariana , Menezes de Faria Pereira Silvia , Leandro da Cruz Larissa , de Souza Passos Michel , Pereira de Moraes Luana , Vieira Ivo José Curcino , Barros de Oliveira Daniela
Published: August 2020

Plants represent the main source of molecules for the development of new drugs, which intensifies the interest of transnational industries in searching for substances obtained from plant sources, especially since the vast majority of species have not yet been studied chemically or biologically, particularly concerning anti-inflammatory action. Anti-inflammatory drugs can interfere in the pathophysiological process of inflammation, to minimize tissue damage and provide greater comfort to the patient. Therefore, it is important to note that due to the existence of a large number of species available for research, the successful development of new naturally occurring anti-inflammatory drugs depends mainly on a multidisciplinary effort to find new molecules. Although many review articles have been published in this regard, the majority presented the subject from a limited regional perspective. Thus, the current article presents highlights from the published literature on plants as sources of anti-inflammatory agents.
Ten New Dammarane-Type Saponins with Hypolipidemia Activity from a Functional Herbal Tea—Gynostemma pentaphyllum
Authors: Yin Maojing , Zhang Jingjing , Wang Lizhi , Li Fangyi , Li Zhenfa , Xiang Wei , Bie Songtao , Wang Chunhua , Li Zheng
Published: August 2020

Gynostemma pentaphyllum (thumb.) Makino is a functional herbal tea commonly used in Asian countries and regions to reduce blood lipid levels. G. pentaphyllum saponin is the main component, but there are still a large number of components with lipid-lowering activity that have not been found. In this study, 10 novel dammarane-type saponins, (1–10) and a known one (11) were isolated from G. pentaphyllum. Ten new compounds were identified and named as yunnangypenosides A-J (1–10), and another known one (11) was also obtained. Their chemical structures were determined by MS, NMR spectroscopic analyses. Moreover, the cytotoxicities on human HepG-2 hepatocellular carcinoma cells of these isolates were evaluated, and the results showed that compounds 1–11 had no obvious cytotoxicity. Finally, all these compounds were evaluated for their lipid-lowering effect by means of the oil red O staining method. Ten compounds could significantly reduce lipid levels except of 2, especially 8 exhibite the strongest hypolipidemia activity.
NMR Metabolomics Applied on the Discrimination of Variables Influencing Tomato (Solanum lycopersicum)
Authors: Abreu Ana Cristina , Fernández Ignacio
Published: August 2020

Tomato composition and nutritional value are attracting increasing attention and interest from both consumers and producers. The interest in enhancing fruits’ quality with respect to beneficious nutrients and flavor/aroma components is based not only in their economic added value but also in their implications involving organoleptic and healthy properties and has generated considerable research interest among nutraceutical and horticultural industries. The present article reviews up to March 2020 some of the most relevant studies based on the application of NMR coupled to multivariate statistical analysis that have addressed the investigation on tomato (Solanum lycopersicum). Specifically, the NMR untargeted technique in the agri-food sector can generate comprehensive data on metabolic networks and is paving the way towards the understanding of variables affecting tomato crops and composition such as origin, variety, salt-water irrigation, cultivation techniques, stage of development, among many others. Such knowledge is helpful to improve fruit quality through cultural practices that divert the metabolism towards the desired pathways and, probably more importantly, drives further efforts towards the differentiation of those crops developed under controlled and desired agronomical conditions.
Screening of Heteroaromatic Scaffolds against Cystathionine Beta-Synthase Enables Identification of Substituted Pyrazolo[3,4-c]Pyridines as Potent and Selective Orthosteric Inhibitors
Authors: Fantel Anna-Maria , Myrianthopoulos Vassilios , Georgoulis Anastasios , Lougiakis Nikolaos , Zantza Iliana , Lamprinidis George , Augsburger Fiona , Marakos Panagiotis , Vorgias Constantinos E. , Szabo Csaba , Pouli Nicole , Papapetropoulos Andreas , Mikros Emmanuel
Published: August 2020

Cystathionine β-synthase (CBS) is a key enzyme in the production of the signaling molecule hydrogen sulfide, deregulation of which is known to contribute to a range of serious pathological states. Involvement of hydrogen sulfide in pathways of paramount importance for cellular homeostasis renders CBS a promising drug target. An in-house focused library of heteroaromatic compounds was screened for CBS modulators by the methylene blue assay and a pyrazolopyridine derivative with a promising CBS inhibitory potential was discovered. The compound activity was readily comparable to the most potent CBS inhibitor currently known, aminoacetic acid, while a promising specificity over the related cystathionine γ-lyase was identified. To rule out any possibility that the inhibitor may bind the enzyme regulatory domain due to its high structural similarity with cofactor s-adenosylmethionine, differential scanning fluorimetry was employed. A sub-scaffold search guided follow-up screening of related compounds, providing preliminary structure-activity relationships with respect to requisites for efficient CBS inhibition by this group of heterocycles. Subsequently, a hypothesis regarding the exact binding mode of the inhibitor was devised on the basis of the available structure-activity relationships (SAR) and a deep neural networks analysis and further supported by induced-fit docking calculations.
Mercury(II) Complexes of Anionic N-Heterocyclic Carbene Ligands: Steric Effects of the Backbone Substituent
Authors: Dash Chandrakanta , Das Animesh , Dias H. V. Rasika
Published: August 2020

Mercury(II) complexes (Me-maloNHCDipp)HgCl (1b), (t-Bu-maloNHCDipp)HgCl (2b) and (t-Bu-maloNHCDipp)HgMe (2c) supported by anionic N-heterocyclic carbenes have been obtained in good yields from the reaction of the potassium salt of N-heterocyclic carbene ligand precursors and mercury(II) salts, HgCl2 and MeHgI. These molecules have been characterized by 1H-NMR, 13C-NMR and IR spectroscopy and elemental analysis. X-ray crystal structures of 1b and 2b are also presented. Interestingly, complex 1b is polymeric {(Me-maloNHCDipp)HgCl}n in the solid state, as a result of inter-molecular Hg-O contacts, and features rare three coordinate mercury sites with a T-shaped arrangement, whereas the (t-Bu-maloNHCDipp)HgCl (2b) is monomeric and has a linear, two-coordinate mercury center. The formation of T-shaped structure and the aggregation of complex 1b is attributable to the reduced steric demand of the N-heterocyclic carbene ligand backbone substituent.
Applications of Photoinduced Phenomena in Supramolecularly Arranged Phthalocyanine Derivatives: A Perspective
Authors: Bettini Simona , Valli Ludovico , Giancane Gabriele
Published: August 2020

This review focuses on the description of several examples of supramolecular assemblies of phthalocyanine derivatives differently functionalized and interfaced with diverse kinds of chemical species for photo-induced phenomena applications. In fact, the role of different substituents was investigated in order to tune peculiar aggregates formation as well as, with the same aim, the possibility to interface these derivatives with other molecular species, as electron donor and acceptor, carbon allotropes, cyclodextrins, protein cages, drugs. Phthalocyanine photo-physical features are indeed really interesting and appealing but need to be preserved and optimized. Here, we highlight that the supramolecular approach is a versatile method to build up very complex and functional architectures. Further, the possibility to minimize the organization energy and to facilitate the spontaneous assembly of the molecules, in numerous examples, has been demonstrated to be more useful and performing than the covalent approach.
Effects of both Pro- and Synbiotics in Liver Surgery and Transplantation with Special Focus on the Gut–Liver Axis—A Systematic Review and Meta-Analysis
Authors: Kahn Judith , Pregartner Gudrun , Schemmer Peter
Published: August 2020

The gut-liver axis is of upmost importance for the development of infections after surgery. Further bacterial translocation due to surgery-related dysbiosis is associated with limited detoxification function of the liver compromising outcome of surgical therapy. After liver surgery, about 30% of patients develop a bacterial infection, with the risk of bacteremia or even sepsis-associated liver failure and mortality in >40%. The potential benefit of pro-/synbiotics given before surgery is still under debate. Thus, a systematic literature search on trials comparing patients with or without supplementation and outcome after liver resection or transplantation was performed. Our search strategy revealed 12 relevant studies on perioperative administration of pro-/synbiotics in liver surgery. The pro-/synbiotic combinations and concentrations as well as administration timeframes differed between studies. Five studies were performed in liver transplantation and 7 in liver resection. All studies but one reported lower infection rates (pooled RR: 0.46, 95% CI: 0.31–0.67) with pro-/synbiotics. Liver function was assessed after LT/LR in 3 and 5 studies, respectively. Pro-/synbiotics improved function in 1/3 and 2/5 studies, respectively. Concluding, perioperative pro-/synbiotics clearly reduce infection after liver surgery. However, standard protocols with both well-defined probiotic strain preparations and administration timeframes are pending.
A Traditional Korean Diet with a Low Dietary Inflammatory Index Increases Anti-Inflammatory IL-10 and Decreases Pro-Inflammatory NF-κB in a Small Dietary Intervention Study
Authors: Shin Phil-Kyung , Park Seon-Joo , Kim Myung Sunny , Kwon Dae Young , Kim Min Jung , Kim KyongChol , Chun Sukyung , Lee Hae-Jeung , Choi Sang-Woon
Published: August 2020

Chronic low-grade inflammation may increase the risk of chronic disease, while diets rich in anti-inflammatory components may reduce it. To determine the anti-inflammatory properties of the traditional Korean diet (K-diet) that comprises high amounts of vegetables, fiber and phytochemicals, moderate amounts of legumes, and low amounts of animal fat, ten obese women aged 50–60 years were randomly assigned to the K-diet or control diet group. The control diet was a Westernized Korean diet commonly consumed in Korea, which is high in animal fat and protein. Subjects were housed in metabolic unit-like conditions during the 2-week intervention. Plasma was collected before and after the intervention to measure inflammatory cytokines using ELISA. The dietary inflammatory index (DII) was calculated based on nutrients and food intake. The DII score for the K-diet was lower than that of the control diet (−0.94 ± 1.39 vs. 1.04 ± 1.61, p < 0.001). In the K-diet group, anti-inflammatory interleukin (IL)-10 levels increased (4.45 ± 0.34 pg/mL vs. 5.94 ± 0.33 pg/mL, p = 0.0102), whereas pro-inflammatory nuclear factor kappa B (NF-κB) levels decreased (7.70 ± 0.62 pg/mL vs. 2.71 ± 0.49 pg/mL, p = 0.0015), but not in the control group. In the K-diet group, NF-κB levels negatively correlated with IL-10 levels (r = −0.794, p = 0.006). The K-diet has anti-inflammatory properties, and IL-10 and NF-κB are putative inflammatory markers for K-diet studies.
Lower Postprandial Thermogenic Response to an Unprocessed Whole Food Meal Compared to an Iso-Energetic/Macronutrient Meal Replacement in Young Women: A Single-Blind Randomized Cross-Over Trial
Authors: Mohr Alex E. , Ramos Carmen , Tavarez Kelvin , Arciero Paul J.
Published: August 2020

In contrast to ultra-processed foods that are associated with increased weight gain and obesity risk, nutritionally engineered dietary supplements, including meal replacement (MR) bars and shakes, are generally promoted as healthy. Limited data is available comparing the metabolic and hunger responses of whole food (WF) versus MR meals. The purpose of this study was to directly compare the thermic effect (TEM), respiratory exchange ratio (RER), hunger/taste ratings, and glucose response of two different breakfast meals containing MR and WF products in young healthy women. Eight volunteers completed two iso-caloric (529 kcals)/macronutrient (50% carbohydrates; 26% fat; 24% protein) test meals in a single-blind, randomized crossover design: (1) whole food meal; or (2) meal replacement. TEM was significantly higher following MR compared with WF (percent mean difference: 7.76 ± 3.78%; absolute mean difference: 0.053 ± 0.026 kcal/minute, p = 0.048), whereas WF substrate utilization demonstrated lower carbohydrate oxidation (RER) than MR (mean difference: −0.024 ± 0.008, p = 0.005). No differences existed for blood glucose response and feelings of hunger, desire to eat, and satiety among trials. Consumption of an MR meal increases postprandial thermogenesis and RER compared to a WF meal, which may impact weight control and obesity risk over the long-term.
Food in Chronic Pain: Friend or Foe?
Authors: Fifi Amanda C. , Holton Kathleen F.
Published: August 2020

While many still consider food to be innocuous, ongoing research demonstrates food’s role, both harmful and protective, in chronic pain [...]
Effect of a Simulated Activity on Student Ability, Preparedness, and Confidence in Applying the Pharmacists’ Patient Care Process to Contraceptive Prescribing
Authors: Lynch Sarah E. , Griffin Brooke , Stewart-Lynch Autumn , Vest Kathleen M.
Published: August 2020

Several states now permit pharmacists to prescribe hormonal contraception. Consequently, some schools of pharmacy now incorporate activities intending to prepare students to offer this service. This study aimed to assess the impact of a simulated activity on student pharmacists’ readiness for, ability to use, and confidence in applying the Pharmacists Patient Care Process along with the United States Medical Eligibility Criteria to a patient seeking contraception. Students completed a contraceptive-prescribing simulation with standardized patients. Scores were analyzed for safe and appropriate prescribing practices. Pre- and post-workshop surveys measured confidence and perceived preparedness. Chi-square and Mann–Whitney U tests were used to analyze categorical variables and Likert-scale data, respectively.The mean activity score was 86% (median 90%), with significant change in student confidence of ability to complete the process (p < 0.0001). The majority of students at baseline (52.2%) and follow up (53.2%) reported needing more practice during advanced pharmacy practice experiences (APPEs) to feel prepared. There was a significant change pre/post in students who agreed that their curriculum prepared them (15% to 28.7%, p = 0.0014). This study suggests that students are able to safely and appropriately prescribe contraception in a simulated activity. The activity increased student reported confidence and moved some students towards readiness for contraceptive prescribing.
Stress Distributions for Hybrid Composite Endodontic Post Designs with and without a Ferrule: FEA Study
Authors: Ausiello Pietro , Gloria Antonio , Maietta Saverio , Watts David C. , Martorelli Massimo
Published: August 2020

The aim of the current work was to analyze the influence of the ferrule effect for hybrid composite endodontic post designs consisting of carbon (C) and glass (G) fiber-reinforced polyetherimide (PEI), in upper canine teeth. Starting from theoretical designs of C-G/PEI hybrid composite posts with different Young’s moduli (Post A—57.7 GPa, Post B—31.6 GPa, Post C—graduated from 57.7 to 9.0 GPa in the coronal–apical direction) in endodontically treated anterior teeth, the influence of the ferrule effect was determined through finite element analysis (FEA). On the surface of the crown, a load of 50 N was applied at 45° to the longitudinal axis of the tooth. Maximum principal stresses were evaluated along the C-G/PEI post as well as at the interface between the surrounding tooth structure and the post. Maximum stress values were lower than those obtained for the corresponding models without a ferrule. The presence of a ferrule led to a marked decrease of stress and gradients especially for posts A and B. A less marked effect was globally found for Post C, except in a cervical margin section along a specific direction, where a significant decrease of the stress was probably due to local geometric features, compared to the model without a ferrule. The presence of a ferrule did not generally provide a marked benefit in the case of the graduated Post C, in comparison to other C-G/PEI posts. The outcomes suggest how such a hybrid composite post alone should be sufficient to optimize the stress distribution, dissipating stress from the coronal to the apical end.
An Overview of Household Energy Consumption and Carbon Dioxide Emissions in Iran
Authors: Rahmani Omeid , Rezania Shahabaldin , Beiranvand Pour Amin , Aminpour Shahram M. , Soltani Mohammad , Ghaderpour Yousef , Oryani Bahareh
Published: August 2020

This review tends to obtain a deeper understanding of the methods used in household energy consumption and carbon dioxide (CO2) emissions in Iran. Issues relating to energy consumption and CO2 emissions are very complex. This complexity arises from the fact that energy demand and energy consumption in Iran are influenced by many factors, such as income, household size, age, and gender. In Iran, the relevant energy sources mostly include liquefied petroleum gas (LPG) and electricity, which are used for different sectors, such as transportation, industry, and residential. This overview looks at both the theories and empirical studies of household energy consumption and CO2 emissions in Iran. Since energy consumption typically results in air pollution, it is often used as an indicator of environmental degradation. Although Iran is recently faced to energy efficiency improvement from all sectors, household energy requirements have been significantly increased. In Iran, a prime motivator had been improving living standards. As Iran gradually turns into a consumer society, households have an enormous influence on the direct use of energy and related CO2 emissions as well as through indirect use, as embodied in goods and services. The findings of this study can help policymakers to focus on renewable energy projects in order to reduce energy consumption and mitigate CO2 emissions.
A Multi-Sensor Unoccupied Aerial System Improves Characterization of Vegetation Composition and Canopy Properties in the Arctic Tundra
Authors: Yang Dedi , Meng Ran , Morrison Bailey D. , McMahon Andrew , Hantson Wouter , Hayes Daniel J. , Breen Amy L. , Salmon Verity G. , Serbin Shawn P.
Published: August 2020

Changes in vegetation distribution, structure, and function can modify the canopy properties of terrestrial ecosystems, with potential consequences for regional and global climate feedbacks. In the Arctic, climate is warming twice as fast as compared to the global average (known as ‘Arctic amplification’), likely having stronger impacts on arctic tundra vegetation. In order to quantify these changes and assess their impacts on ecosystem structure and function, methods are needed to accurately characterize the canopy properties of tundra vegetation types. However, commonly used ground-based measurements are limited in spatial and temporal coverage, and differentiating low-lying tundra plant species is challenging with coarse-resolution satellite remote sensing. The collection and processing of multi-sensor data from unoccupied aerial systems (UASs) has the potential to fill the gap between ground-based and satellite observations. To address the critical need for such data in the Arctic, we developed a cost-effective multi-sensor UAS (the ‘Osprey’) using off-the-shelf instrumentation. The Osprey simultaneously produces high-resolution optical, thermal, and structural images, as well as collecting point-based hyperspectral measurements, over vegetation canopies. In this paper, we describe the setup and deployment of the Osprey system in the Arctic to a tundra study site located in the Seward Peninsula, Alaska. We present a case study demonstrating the processing and application of Osprey data products for characterizing the key biophysical properties of tundra vegetation canopies. In this study, plant functional types (PFTs) representative of arctic tundra ecosystems were mapped with an overall accuracy of 87.4%. The Osprey image products identified significant differences in canopy-scale greenness, canopy height, and surface temperature among PFTs, with deciduous low to tall shrubs having the lowest canopy temperatures while non-vascular lichens had the warmest. The analysis of our hyperspectral data showed that variation in the fractional cover of deciduous low to tall shrubs was effectively characterized by Osprey reflectance measurements across the range of visible to near-infrared wavelengths. Therefore, the development and deployment of the Osprey UAS, as a state-of-the-art methodology, has the potential to be widely used for characterizing tundra vegetation composition and canopy properties to improve our understanding of ecosystem dynamics in the Arctic, and to address scale issues between ground-based and airborne/satellite observations.
Novel Pole Photogrammetric System for Low-Cost Documentation of Archaeological Sites: The Case Study of “Cueva Pintada”
Authors: Del Pozo Susana , Rodríguez-Gonzálvez Pablo , Hernández-López David , Onrubia-Pintado Jorge , Guerrero-Sevilla Diego , González-Aguilera Diego
Published: August 2020

Close-range photogrammetry is a powerful and widely used technique for 3D reconstruction of archaeological environments, specifically when a high-level detail is required. This paper presents an innovative low-cost system that allows high quality and detailed reconstructions of indoor complex scenarios with unfavorable lighting conditions by means of close-range nadir and oblique images as an alternative to drone acquisitions for those places where the use of drones is limited or discouraged: (i) indoor scenarios in which both loss of GNSS signal and need of long exposure times occur, (ii) scenarios with risk of raising dust in suspension due to the proximity to the ground and (iii) complex scenarios with variability in the presence of nooks and vertical elements of different heights. The low-altitude aerial view reached with this system allows high-quality 3D documentation of complex scenarios helped by its ergonomic design, self-stability, lightness, and flexibility of handling. In addition, its interchangeable and remote-control support allows to board different sensors and perform both acquisitions that follow the ideal photogrammetric epipolar geometry but also acquisitions with geometry variations that favor a more complete and reliable reconstruction by avoiding occlusions. This versatile pole photogrammetry system has been successfully used to 3D reconstruct and document the “Cueva Pintada” archaeological site located in Gran Canaria (Spain), of approximately 5400 m2 with a Canon EOS 5D MARK II SLR digital camera. As final products: (i) a great quality photorealistic 3D model of 1.47 mm resolution and ±8.4 mm accuracy, (ii) detailed orthophotos of the main assets of the archaeological remains and (iii) a visor 3D with associated information on the structures, materials and plans of the site were obtained.
On the Radiative Transfer Model for Soil Moisture across Space, Time and Hydro-Climates
Authors: Neelam Maheshwari , Mohanty Binayak P.
Published: August 2020

A framework is proposed for understanding the efficacy of the microwave radiative transfer model (RTM) of soil moisture with different support scales, seasonality (time), hydroclimates, and aggregation (scaling) methods. In this paper, the sensitivity of brightness temperature TB (H- and V-polarization) to physical variables (soil moisture, soil texture, surface roughness, surface temperature, and vegetation characteristics) is studied. Our results indicate that the sensitivity of brightness temperature (V- or H-polarization) is determined by the upscaling method and heterogeneity observed in the physical variables. Under higher heterogeneity, the TB sensitivity to vegetation and roughness followed a logarithmic function with an increasing support scale, while an exponential function is followed under lower heterogeneity. Surface temperature always followed an exponential function under all conditions. The sensitivity of TB at H- or V- polarization to soil and vegetation characteristics varied with the spatial scale (extent and support) and the amount of biomass observed. Thus, choosing an H- or V-polarization algorithm for soil moisture retrieval is a tradeoff between support scales, and land surface heterogeneity. For largely undisturbed natural environments such as SGP’97 and SMEX04, the sensitivity of TB to variables remains nearly uniform and is not influenced by extent, support scales, or an upscaling method. On the contrary, for anthropogenically-manipulated environments such as SMEX02 and SMAPVEX12, the sensitivity to variables is highly influenced by the distribution of land surface heterogeneity and upscaling methods.
A Robotic Cognitive Architecture for Slope and Dam Inspections
Authors: Pinto Milena F. , Honorio Leonardo M. , Melo Aurélio , Marcato Andre L. M.
Published: August 2020

Big construction enterprises, such as electrical power generation dams and mining slopes, demand continuous visual inspections. The sizes of these structures and the necessary level of detail in each mission requires a conflicting set of multi-objective goals, such as performance, quality, and safety. It is challenging for human operators, or simple autonomous path-following drones, to process all this information, and thus, it is common that a mission must be repeated several times until it succeeds. This paper deals with this problem by developing a new cognitive architecture based on a collaborative environment between the unmanned aerial vehicles (UAVs) and other agents focusing on optimizing the data gathering, information processing, and decision-making. The proposed architecture breaks the problem into independent units ranging from sensors and actuators up to high-level intelligence processes. It organizes the structures into data and information; each agent may request an individual behavior from the system. To deal with conflicting behaviors, a supervisory agent analyzes all requests and defines the final planning. This architecture enables real-time decision-making with intelligent social behavior among the agents. Thus, it is possible to process and make decisions about the best way to accomplish the mission. To present the methodology, slope inspection scenarios are shown.