bluuebunny/crossref_metadata_2025 huggingface dataset:
Use of Remdesivir in Patients with SARS-CoV-2 Pneumonia in a Real-Life Setting during the Second and Third COVID-19 Epidemic Waves
Authors: Marocco Raffaella , Del Borgo Cosmo , Tortellini Eeva , Garattini Silvia , Carraro Anna , Di Trento Daniela , Gasperin Andrea , Grimaldi Alessandra , Tieghi Tiziana , Belvisi Valeria , Kertusha Blerta , Guardiani Mariasilvia , Zuccalà Paola , Alunni Fegatelli Danilo , Spagnoli Alessandra , Lichtner Miriam ,   LATINA COVID-group
Published: April 2023

In this retrospective comparative study, we evaluated the effectiveness of remdesivir (RDSV) in patients with SARS-CoV-2 pneumonia. Individuals hospitalized between March 2020 and August 2022 at S.M. Goretti Hospital, Latina, with a positive test for SARS-CoV-2 and, concomitantly, pneumonia, were included. The overall survival was the primary endpoint. The composite secondary endpoint included death or progression in severe ARDS at 40 days. The study population was stratified according to treatment into two groups: the RDSV group (patients treated with RDSV-based regimens) and the no-RDSV group (patients treated with any other, not RDSV-based, regimens). Factors associated with death and progression to severe ARDS or death were assessed by multivariable analysis. A total of 1153 patients (632 belonging to the RDSV group and 521 to the no-RDSV group) were studied. The groups were comparable in terms of sex, PaO2/FiO2 at admission, and duration of symptoms before hospitalization. Further, 54 patients (8.5%) in the RDSV group and 113 (21.7%) in the no-RDSV group (p < 0.001) died. RDSV was associated with a significantly reduced hazard ratio (HR) of death (HR, 0.69 [95% CI, 0.49–0.97]; p = 0.03), compared to the no-RDSV group, as well as a significantly reduced OR of progression in severe ARDS or death (OR, 0.70 [95% CI 0.49–0.98]; p = 0.04). An overall significantly higher survival rate was observed in the RDSV group (p < 0.001, by log-rank test). These findings reinforce the survival benefit of RDSV and support its routine clinical use for the treatment of COVID-19 patients.
Un précurseur de la pédiatrie à Bordeaux, Jean-Marie Caillau (1765-1820)
Authors: Battin Jacques
Published: April 2023

Jean-Marie Caillau a retenu la leçon des philosophes des Lumières. La science, fruit de l’observation et de la raison, est à partager avec le plus grand nombre. Educateur par nature, il enseigna pendant vingt ans la médecine des enfants, s’insurgea contre leur effroyable mortalité, en dénonça les causes. Il comprit l’intérêt de former les mères aux soins primaires en écrivant à leur intention un journal. Il fut ainsi un des premiers médecins de santé publique, discipline qui devint par la suite si liée à la pédiatrie. L’importance attachée à l’éducation morale du futur citoyen le fait apparaître aussi comme un des premiers psychologues de l’enfant.
State policy in the sphere of environmental protection: the regulatory aspect
Authors: Kryzhevskyi Vitalii , Ripenko Artem , Nikitin Volodymyr , Kozin Serhii , Kuzmenko Dmytro
Published: April 2023

The purpose of the article is to analyze the normative and legal aspect of public policy in the field of environmental protection and generalize the relevant legislative basis. Research results. The understanding of the concept of “sphere of the environment” and the content of its legal regulation are generalized. It is substantiated that under the European integration, adaptation of international experience to domestic legal realities, as well as harmonization of national and international legislation the development of the latest forms and methods of environmental protection is an urgent issue. Practical meaning. It is noted that there is a critical need to develop new and improve existing legal acts, taking into account modern trends, since the war unleashed by Russia on the territory of Ukraine causes critical damage to the environment and ecology of Ukraine, and accordingly, such actions must be properly qualified. Value/originality. The perspective of further research is the need to analyze the methods of protection in the field of environmental protection, which are defined as effective tools for the protection of nature from harmful effects. Informative and complementary to research is the question of using international experience in improving the relevant national mechanism.
Notas para leer ¡Qué cosa, la cosa pública!
Authors: Vinuesa Lucía
Published: April 2023

Reseña de: ¡Qué cosa, la cosa pública! Apuntes shakespeareanos para una república popular. Rinesi, Eduardo. 2021. Buenos Aires: Ubu editorial, 280 pp.
A los afrodescendientes “nos los pintan” como criminales. Cultura y biopolítica por el espacio urbano
Authors: Espinosa Eduardo Luis
Published: April 2023

Este artículo se enfoca en la dilucidación de los mecanismos culturales y biopolíticos que actúan en la criminalización de los afrodescendientes en áreas de la ciudad de La Habana en las últimas tres décadas. Ese prejuicio que lleva a la intervención policial en la vida de los afrocubanos, se revela en los marcos de la simbolización del imaginario de una nación unificada, sin contrastes raciales, y del continuum de un Estado totalitario. La criminalización viene de una raíz colonial. En ella se conjugan el control social y la cultura. El primero se vale de viejas construcciones coloniales de la jerarquía social. La segunda mantiene esas hechuras poscoloniales entre su naturalización y los embates de la lucha por la igualdad.
Modular, Articulated Models of DNA and Peptide Nucleic Acids for Nanotechnology Education
Authors: Goodwin-Schoen Caleigh M. , Taylor Rebecca E.
Published: April 2023

Dynamic and flexible nucleic acid models can provide current and future scientists with physical intuition for the structure of DNA and the ways that DNA and its synthetic mimics can be used to build self-assembling structures and advanced nanomachines. As more research labs and classrooms dive into the field of structural nucleic acid nanotechnology, students and researchers need access to interactive, dynamic, handheld models. Here, we present a 3D-printable kit for the construction of DNA and peptide nucleic acid (PNA). We have engineered a previous modular DNA kit to reduce costs while improving ease of assembly, flexibility, and robustness. We have also expanded the scope of available snap-together models by creating the first 3D-printable models of γPNA, an emerging material for nuclease- and protease-resistance nanotechnology. Building on previous research, representative nucleic acid duplexes were split into logical monomer segments, and atomic coordinates were used to create solid models for 3D printing. We used a human factors approach to customize 3 types of articulated snap-together connectors that allow for physically relevant motion characteristic of each interface in the model. Modules are easy to connect and separate manually but stay together when the model is manipulated. To greatly reduce cost, we bundled these segments for printing, and we created a miniaturized version that uses less than half the printing material to build. Our novel 3D-printed articulated snap-together models capture the flexibility and robustness of DNA and γPNA nanostructures. Resulting handheld helical models replicate the geometries in published structures and can now flex to form crossovers and allow biologically relevant zipping and unzipping to allow complex demonstrations of nanomachines undergoing strand displacement reactions. Finally, the same tools used to create these models can be readily applied to other types of backbones and nucleobases for endless research and education possibilities.
ПРОБЛЕМИ ФУНКЦІОНУВАННЯ ПРАВОВОГО Й ОРГАНІЗАЦІЙНОГО МЕХАНІЗМІВ ПУБЛІЧНОГО УПРАВЛІННЯ ЯКІСТЮ ПОСЛУГ ВОДОПОСТАЧАННЯ ТА ВОДОВІДВЕДЕННЯ МІСТА В УКРАЇНІ
Authors: Кордиш Д. Є.
Published: April 2023

У статті представлено результати проведеного дослідження у сфері функціонування правового й організаційного механізмів публічного управління якістю послуг водопостачання та водовідведення міста в Україні. Зокрема, визначено, що функціонування правового механізму публічного управління якістю послуг водопостачання та водовідведення міста в Україні передбачає прийняття та виконання низки спеціальних нормативно-правових актів. Установлено, що організаційний механізм публічного управління якістю послуг водопостачання й водовідведення міста в Україні передбачає створення та функціонування органів публічної влади (державних і самоврядних). Виявлено, що за кордоном сформувалися дві класичні моделі публічного управління у сфері водопостачання та водовідведення міста. Перша модель визначає, що існує центральний орган влади як регулятор у цій сфері, а відповідно до другої моделі здійснено приватизацію у сфері водовідведення та водопостачання. Акцентовано, що в Україні з моменту проголошення її незалежності впроваджена була спочатку друга модель, яка діяла до 2011 року. Проте, починаючи з цього періоду, діє гібридна модель – публічного управління у сфері водопостачання та водовідведення. З’ясовано, що в межах цієї моделі створено та функціонує НКРЕКП, а також регулятивні функції у сфері водовідведення та водопостачання виконують органи місцевого самоврядування. З’ясовано, що в Україні діє ринок послуг з водопостачання та водовідведення, який представлено як систему економічних відносин між виробником послуги та її споживачем, що виникає в процесі купівлі-продажу. Проте порівняння з основними напрямками регулювання в іноземних регуляторів сфери водовідведення та водопостачання, дало змогу стверджувати, що серед цих напрямків є ринок послуг, якість послуг, якість води, захист довкілля, ціна, захист інтересів і безпека споживачів. На цій підставі обґрунтовано завдання для України, що полягає в коригуванні моделі публічного управління у сфері водопостачання та водовідведення, в напрямку забезпечення її високоякісності.
Analysis of longitudinal leaky surface acoustic waves on piezoelectric thin plates bonded to diamond substrate
Authors: Hara Naoto , Suzuki Masashi , Kakio Shoji , Yamamoto Yasushi
Published: April 2023

Using the finite element method, we analyzed the resonance properties of a longitudinal leaky surface acoustic wave (LLSAW) on the structure of a piezoelectric LiTaO3 (LT) or LiNbO3 (LN) thin plate bonded to a diamond support substrate. When the plate thickness was 0.3 wavelength or larger, the particle displacements of the LLSAW were substantially concentrated near the surface, and the resonance properties were significantly improved compared to those of the single LT or LN. However, spurious responses due to other SAW modes also emerged. Regarding the LN thin plate, we obtained a phase velocity and fractional bandwidth of approximately 7300 m s−1 and 9.4%, respectively. Furthermore, a structure was proposed to suppress spurious responses in which the piezoelectric thin plate is divided into two layers with different Euler angles. The spurious responses were significantly suppressed after dividing the thin plate, while the main response of the LLSAW was maintained.
Recalcularea numărului populației Republicii Moldova, 2004-2014
Authors: Gagauz Olga
Published: April 2023

Această analiză face parte din Programul UNFPA de reziliență demografică pentru Europa și Asia Centrală lansat de Fondul Națiunilor Unite pentru Populație în 2021 cu scopul de a susține și dezvolta capacitățile țărilor din regiune, inclusiv Republica Moldova, de a elabora politici bazate pe evidențe și programe destinate societății și populației, pentru a răspunde la schimbările demografice și a consolida capitalul uman.
ESTIMASI CADANGAN KLAIM PRODUK ASURANSI JIWA KREDIT UNTUK PESERTA PENSIUN
Authors: Catur Widyo Utomo  , Awaloedin Mulawarman
Published: April 2023

Theoretically, insurance companies rarely suffer losses. Insurance companies in managing finances, are very careful, because they will face possible risks in the future in the form of claim payments. Therefore, in selling the products, they do not use the usual forms of marketing. They use agents and brokers in distributing risk products that are sold. In addition, for certain reasons, the company also cooperates with other parties. This cooperation is essentially a form of strategic alliance. Namely cooperation between the insurance company as the issuer of the policy with the bank as the owner of credit for customers. The problem is how insurance companies face the risk of claims in the future for bank customers who have retired status and are vulnerable to the risk of death. This article discusses term loans from customers at a bank as the insured who has retired status and they are guaranteed by an insurance company as the insurer. How much funds are provided by the insurer in the future to pay the risk of death (claims) of the insured? Using the semi-continuous prospective reserve method for term life insurance products, the results show that the insurer is experiencing liquidity difficulties in order to bear the burden of claims that have already occurred and are expected to suffer losses later. The reinsurance scheme offered has also not been able to cover the insurer's losses. Therefore, the most feasible scheme to assist the insurer's liquidity due to high claims is to enlarge new policies through the scheme of entry age for the insured with a younger age while continuing to run the reinsurance scheme.
Pengaruh Pelayanan Pengelola Terhadap Kepuasan Nasabah Bank Sampah
Authors: Wirawan Aldy , Yandri Pitri
Published: April 2023

Waste banks are increasingly important to assist government programs in reducing household waste.  The government has recognized the existence of waste banks as community-based waste management organizational entities through various laws and regulations. As an organization, waste banks must also adhere to sound management principles, including how to serve service users/customers (in this case, people who save their waste). However, research on waste banks focuses a lot on their role in the environment and how their members participate. Here, research related to management services functions is rarely carried out by researchers. Therefore, this study examines the effect of management services on the satisfaction of waste bank customers. We use the service and customer satisfaction theory and break it down into measurable indicators. This study looked at the Hibiscus Waste Bank in South Tangerang City. To answer the formulation of the problem, we surveyed more than 30 customers purposively through a questionnaire instrument. Then we examined it with the Structural Equation Modelling. We found strong evidence that physical evidence, responsiveness, empathy, assurance, and service reliability significantly affected waste bank customer satisfaction. Further elaboration of the findings we present more fully in this article.
PENGARUH GAYA KEPEMIMPINAN DAN MOTIVASI TERHADAP PRODUKTIVITAS KERJA PEGAWAI
Authors: Febrian Rizki , Ekowati Sri
Published: April 2023

This study aims to determine the effect of leadership style and motivation on work productivity (a case study on employees of PT. Kimia Farma Bengkulu branch). This type of research is a quantitative descriptive research. The object of this research is the employees of PT. Kimia Farma Bengkulu. The sampling method is a saturated sampling technique. The number of respondents in this study were 40 respondents. The method of data collection is using the distribution of questionnaires. The data analysis technique used multiple linear regression analysis and hypothesis testing, namely t test and F test.
The results of this study can be concluded that the variables of leadership style and motivation have a positive and significant effect on work productivity at PT. Pharmaceutical Chemistry. Partially, the two variables of leadership style and motivation have a positive and significant influence on work productivity. The better the leadership style and the better the motivation given in accordance with the employee's work, the work productivity will increase.
 Keywords: Leadership Style, Motivation, Work Productivity
PENGARUH MOTIVASI KERJA DAN LINGKUNGAN KERJA TERHADAP KINERJA KARYAWAN PT. FIF CURUP
Authors: Ramadhan Gilang , Islamuddin Islamuddin
Published: April 2023

Given the importance of employee motivation, work motivation is one of the factors that need attention from company leaders. Problem formulation 1) Is there any influence of work motivation on employee performance of PT. FIF Curup? 2) Is there any influence of the work environment on the performance of employees of PT. FIF Curup? 3) Is there any influence of work motivation and work environment on the performance of employees of PT. FIF Curu This study aims 1) To determine the effect of work motivation on the performance of employees of PT. FIF Curup 2) To determine the effect of the work environment on the performance of employees of PT. FIF Curup? 3) To determine the effect of work motivation and work environment on the performance of employees of PT. FIF Curup. This type of research is a quantitative approach. The method used in this research is descriptive method. The population in this study were all employees at PT. FIF Curup has 35 employees. a sample of 35 people PT. FIF Curup. Based on the results of research on the influence of work motivation and work environment on employee performance at PT. FIF Curup. The tSig value for the work motivation variable (X1) is 0.002. So it can be concluded that tSig<Sig (0.002<0.050 ) means that Ha is accepted and H0 is rejected, that the variable of work motivation affects the performance of employees of PT. FIF Curup. The tSig value for the work environment variable (X2) is 0.001. So it can be concluded that tSig<Sig (0.001<0.050 ) means Ha is accepted and H0 is rejected, that the work environment variable affects the performance of employees of PT. FIF Curup. The hypothesis test above can be seen for the variable work motivation (X1), and work environment (X2) the value of Fsig = 0.004. So it can be concluded that FSig < Sig (0.004 < 0.050 ) means Ha is accepted and H0 is rejected, that each variable has a significant effect on employee performance (Y) at PT. FIF Curup.
Keywords: Work Motivation, Work Environment, Employee Performance,
PENGARUH LINGKUNGAN KERJA DAN KEPUASAN KERJA TERHADAP KINERJA KARYAWAN
Authors: Amelia Kiki Rizki , Ratnawili Ratnawili
Published: April 2023

This study aims to analyze the Effect of Work Environment and Job Satisfaction on Employee Performance at the Hulu Palik Health Center, North Bengkulu Regency, both partially and simultaneously. The objects used in this study were 40 employees of the Hulu Palik Health Center, North Bengkulu Regency. In this study, the authors used data collection methods by means of observation, interviews and questionnaires. This type of research is quantitative, there are several data analysis techniques used in this study including using instrument tests, classical assumption tests, respondent response analysis, multiple linear regression analysis, coefficient of determination, and hypothesis testing. The result of this study is that the Work Environment variable affects employee performance. Job satisfaction has a positive and significant effect on employee performance. Work Environment and Job Satisfaction have a simultaneous effect on Employee Performance at the Hulu Palik Health Center, North Bengkulu Regency.
Keywords : Work Environment, Job Satisfaction and Employee Performance.
PENGARUH BRAND EQUITY, BRAND TRUST DAN BRAND PREFERENCE TERHADAP LOYALITAS PELANGGAN THREE SECOND DI BENCOOLEN INDAH MALL BENGKULU
Authors: Prayoga Amanda , Arianto Tezar
Published: April 2023

This study plans to decide the impact of Brand Equity, Brand Trust and Brand Preference on Three Second Customer Loyalty at Bencoolen Indah Mall Bengkulu. The populace utilized in this examination is Three Second Customers at Bencoolen Indah Mall Bengkulu. the quantity of tests utilized upwards of 75 respondents. The information that has been gathered is handled utilizing the Classical Assumption Test Technique, Multiple Linear Regression Analysis Technique, Coefficient of Determination Analysis (R2), and Partial Test (t-test), Simultaneous Test (F-test).The consequences of this study show that somewhat the Brand Equity variable fundamentally affects the Customer Loyalty variable, Brand Trust essentially affects the Customer Loyalty variable and Brand Preference altogether affects the Customer Loyalty variable. While the f Brand Equity Test, Brand Trust and Brand Preference impact Three Second Customer Loyalty at Bencoolen Indah Mall Bengkulu. As well as having a relapse condition together, the Brand Equity, Brand Trust and Brand Preference factors add to impacting Three Second Customer Loyalty at Bencoolen Indah Mall Bengkulu. Also, the most predominant element with the biggest relapse coefficient esteem is the Brand Trust variable.
Keywords: Brand Equity, Brand Trust, Brand Preference and Customer Loyalty.
PENGARUH PROMOSI TERHADAP KEPUTUSAN PEMBELIAN PADA PT. SUTAN KASIM CABANG KOTA BENGKULU
Authors: Prilianto Randi , Arini Eti
Published: April 2023

The influence of the promotion that is given makes the arrival of consumers increase so that it affects sales turnover. This study aims: to determine the effect of promotion on purchasing decisions at PT. Sutan Kasim Bengkulu City Branch. This type of research is a quantitative approach. The method used in this research is descriptive method. The population in this study were all consumers of PT. Sutan Kasim Bengkulu City Branch. the sample is 50 consumers of PT. Sutan Kasim Bengkulu City Branch. Based on the results of research on the Effect of Promotional Strategies on Purchase Decisions at PT. Sutan Kasim Bengkulu City Branch, the following conclusions can be drawn: 1). For the place of research, it is hoped that PT. Sutan Kasim to continue to maintain promotions in order to maintain consumer purchasing decisions because more consumers who buy will increase business income. 2). It is hoped that PT. Sutan Kasim in order to maintain consumer purchasing decisions so that turnover does not decrease.3). For academics, PT. Sutan Kasim pays attention to promotion variables because they have more influence on purchasing decisions.
Keywords: Promotion, Purchase Decision
PENGARUH CITRA MEREK, KUALITAS PRODUK DAN HARGA TERHADAP KEPUASAN KONSUMEN AC DAIKIN CV CENTRAL ELEKTRO
Authors: Kurniawansyah Roni , Fitri Marliza Ade
Published: April 2023

This study aims to determine the effect of brand image, product quality and price on consumer satisfaction of AC Daikin CV Central Elektro. This type of research uses descriptive quantitative research methods. The population used in this study is the Consumer AC Daikin CV Central Elektro. The number of respondents in this study were 110 people. Methods of data collection using questionnaires and using analytical techniques using multiple linear regression analysis test and hypothesis testing, namely t test and f test. Based on the results of multiple linear regression, the regression equation form Y = 5.265 + 0.297X1 + 0.153X2 + 0.278X3 and the results of the t test and f test of this study can be concluded that Brand Image has a positive and significant effect on consumer satisfaction. Product quality has a positive and significant effect on consumer satisfaction. Price has a positive and significant effect on consumer satisfaction. Brand Image (X_1), Product Quality (X_2) and Price (X3) together have a positive and significant effect on Consumer Satisfaction (Y) on AC Daikin CV Central Elektro.
PENGARUH INSENTIF DAN DUKUNGAN ORGANISASI TERHADAP KINERJA KARYAWAN PADA PT. SINAR MITRA SEPADAN FINANCE CABANG KOTA BENGKULU
Authors: Putra EY Yoega Dwi , Arini Eti
Published: April 2023

This study aims to determine the effect of incentives and organizational support on employee performance at PT. Sinar Mitra Sepadan Finance Bengkulu Branch. This type of research is a type of quantitative descriptive research, the object of this research is the employees of PT. Sinar Mitra Sepadan Finance Bengkulu Branch. The sampling method used a non-probabilty technique, namely accidental sampling. The number of respondents in this study were 40 people. Methods of data collection using a questionnaire. The data analysis technique uses Multiple Linear Regression Analysis Test, and Hypothesis Testing, namely t-test and f-test.
The results of this study can be concluded that the Incentive variable has a positive effect on Employee Performance, Organizational Support has a positive effect on Employee Performance, Incentives and Organizational Support together have a positive and significant effect on Employee Performance.
Keywords: Incentives, Organizational Support, Employee Performance
KERJA DAN KESELAMATAN KERJA TERHADAP KINERJA KARYAWAN PADA PT.PLN (PERSERO) WILAYAH S2JB CABANG BENGKULU
Authors: Bustami Taufik , Mardiana Dina
Published: April 2023

This research is based on the fact that occupational health insurance and occupational safety insurance have a positive effect on employee performance. looking for whether there is an effect of occupational health and safety guarantees on the performance of employees of PT. PLN (Persero) area S2JB Bengkulu Branch. In this research, the type of research is quantitative, which means the type of research based on the philosophy of positivism, is used to examine certain populations or samples.
The object of this research is all permanent employees at PT. PLN (Persero) Region S2JB Bengkulu Branch, totaling 50 employees and the sampling technique used by the researcher for this research is saturated/census sampling, which is a sampling technique if all of the population is used as a sample. Methods of data collection using a questionnaire
By using multiple linear regression analysis technique, the results of this study can be concluded that the occupational health insurance variable has a positive and significant effect on employee performance and the work safety insurance variable has a positive and significant effect on employee performance.
Keywords : Occupational health insurance, work safety assurance and employee performance
A Deep Neural Network Modeling Methodology for Extraction of RLGC Parameters in µ-wave and mm-wave Transmission Lines
Authors: Newberry Stephen , Zadehgol Ata
Published: April 2023

Transmission line geometry is one of the most critical aspects of high-speed digital and radio frequency (RF) printed circuit board (PCB) design. While relatively simple equation-based methods exist to estimate transmission line parameters such as characteristic impedance, they do not hold accuracy beyond certain structural limitations such as track width to dielectric thickness ratios. Electromagnetic field solvers have become far more common in recent times and can deliver exceptional accuracy with relatively low computational cost. This paper describes a proof-of-concept neural net which utilizes five input parameters of an uncoated microstrip transmission line and is able to output the per-unit-length equivalent resistance, inductance, conductance, and capacitance RLGC parameters. The goal of a deep-learning based transmission line tool is to enable  accurate microstrip and stripline PCB trace design with computation speeds which allow the engineer to compute hundreds or thousands of iterations in a short period of time with commodity hardware. The final model calculates characteristic impedance with less than ±1.33 Ω error for 100,000 swept samples when the samples are within the middle 90% range of the training data and with a computation speed increase of 14.5 times faster than the benchmark field solver.
Enabling New Generation Services with Multi-Level Delegation Architecture of Slicing Technology
Authors: Dandoush Abdulhalim , Kammoun Amal , diaz gladys , achir nadjib , Tabbane Nabil
Published: April 2023

5G/6G network slicing is identified as key enabler technology for allowing a diversity of sustainable applications while satisfying user’s requirements. A major problem of the traditional networking technologies is the use of the ”one size fits all” approach that handles all types of services. In this work, we focus on drawing a new architecture born of the need of a multi-level services’ orchestration for seeking flexible intelligent management of the new generation use-cases such as massively deployed cloud and edge-cloud based IoT applications for (i) environment monitoring, (ii) Agriculture development, (iii) and new generation Augmented Reality applications in medicine or e-learning.Thispaperproposesanovelmulti-levelDelegationArchitecture for Network Slicing Orchestration (DANSO). DANSO proposes a multi-level delegation for slices management and optimization framework for resources allocation. Our proposal is based on three pillars: (i) definition of levels to fulfill support of network slicing deployment and management via delegated decisions (ii) split of orchestrator, manager and control roles and (iii) placement-independence of entities in (ii). DANSO has the following advantages. First, it provides an optimization mechanism for the deployment of network slices. second, it takes into consideration a negotiation process for the requested slice. Third, it manages the life-cycle not only for the Virtual Network Function (VNF) level but also for the dynamic deployment and suppression of the whole slices. last, it considers network slicing over several administrative domains. 
An Overview of Recent Development of the Gap-Waveguide Technology for mmWave and sub-THz Applications
Authors: Yong Wai Yan , Vosoogh Abbas , Bagheri Alireza , Van de Ven Coen , Haddadi Abolfalz , Alayon Glazunov Andres
Published: April 2023

Interest in the mmWave and sub-THz bands for next-generation communication and radar systems is increasingly growing due to the available electromagnetic spectrum. This has led to an urgent need to develop low-loss and low-fabrication-cost technologies that perform well at these frequencies. The Gap Waveguide (GW) technology is an emerging and viable contender for the development of radio frequency passive components and antenna systems. The GW technology is based on the parallel-plate waveguide principle. According to Maxwell's equations, ideally, no wave propagates within a structure if the top plate consists of a perfect electric conductor (PEC) while the bottom plate is a perfect magnetic conductor (PMC), and the distance between the plates is less than a quarter wavelength. This PMC structure creates high surface impedance characteristics which provide cutoff to all propagating modes within the airgap. In practice, these magnetic conductors can be created artificially using an Electromagnetic Band Gap (EBG) structure. Based on this simple principle, considerable research and development of novel components with high performance has seen the light in the past decade. The purpose of this paper is to present an overview of current advancements in the design and technical implementations of GW-based antenna systems and components. Practical applications and the industry interest in the developments of the GW technology for mmWave and sub-THz applications have also been scrutinized.
«Con assoluta sincerità»
Authors: Bassi Giulia
Published: April 2023

«With absolute honesty»: this is how Natalia Ginzburg worked in her editorial job at the Einaudi publishing house. Through documents from the Einaudi Archives in Turin and the Archivio del Novecento (Sapienza University), this book traces Ginzburg's editorial work in the postwar period, when she had major editorial responsibility and coordinated the translation of Proust’s Recherche. The correspondences with authors and translators restore a new profile of the writer, bringing to light the relevance of her intervention in narrative series, such as “Coralli” and “Gettoni”; the interaction between the professions of writer, editor and translator, from which recurring elements of poetics emerge; and the issues involved in being the only woman to have a decision-making role in the Einaudi editorial staff of the time.
Bilateral Retropharyngeal Internal Carotid Artery ‘Kissing Carotids’: A Case Report
Authors: Garmane A. , Outaghyame S. , Slioui B. , Hammoune N. , Belasri S. , Mouhsine A.
Published: April 2023

Aberrant course of the internal carotid arteries is a rare congenital malformation, accounts for 5% of cases. Several cases of fatal hemorrhage due to an injury to the aberrant internal carotid artery have been observed in patients undergoing pharyngeal surgery procedures. This was associated with a lack of detection during surgery. We report a case of aberrant commun and internal carotid arteries, manifested by odynophagia. This particular anatomical condition should be suspected in patients with pharyngeal mass before any invasive procedure.
Spontaneous Intra Peritoneal Rupture of a Hepatic Hydatic Cyst: A Case Report
Authors: Choukri Ahmanna Hussein- , Bouktib Y. , Hajjami A. El , Boutakioute B. , Idrissi M Ouali , Guennouni N. Cherif Idrissi El
Published: April 2023

Hydatid disease in people is mainly caused by infection with the larval stage of the dog tapeworm Echinococcus granulosus, A 27-year-old men was admitted with a more than a week history of abdominal pain with a perception of an abdominal mass, the evolution was marked by the disappearance of the abdominal mass and installation of an abdominal distention with a generalized pruritus and cutaneous erythema; the chest X-Ray showed an elevation of the right diaphragmatic dome, An abdominal ultrasound were performed demonstrating a cystic formation, appearing to develop in the right liver, n, containing multiple membranous formations and floating serpiginous with peritoneal effusion of great abundance finely echogenic, it associates vesicular formations visible at the pelvic; The abdominal CT confirmed ruptured hepatic cyst; the patient was managed in the surgical unit and was initiated on albendazole treatment with good follow up. Rupture into the free peritoneum is a complication that occurs in 2-7% of cases Rupture rate is commonly reported as approximately 20% and is associated with young age, superficial localization, trauma, and large cyst size. The anaphylaxis rate has been reported as 10% in all ruptured cases in one series. The rupture can occur after a trauma, or spontaneously as a result of increased intracystic pressure. The spontaneous intra peritoneal rupture of a hepatic hydatic cyst is a serious complication and a particular situation from its clinical presentation to imaging features.
Effect of Aloe Vera Extract and Second Line Anti-Tuberculosis Drugs on Mycobacterium Tuberculosis Strain-H37Rv
Authors: Azal Shaikh , V Zodape, G.
Published: April 2023

The present study was undertaken to examine the direct effect of second line anti-tuberculosis drugs Ethionamide (ETH), Para amino salicylic acid (PAS), Aloe vera on Mycobacterium tuberculosis (MTB) strain H37Rv ATCC No- 27294. It is found that Aloe vera does not interfere with single or in the combination of both ETH and PAS showing the bioenhancer activity. In vitro study of Aloe vera observed that the extract inhibited the growth of H37Rv strains. The present results will pave new avenues to find a new medicine that possesses Aloe vera alone or in combination with drugs to combat H37Rv strains controlling tuberculosis.
Total Laparoscopic Approach for a Gastric Tumor Associated With an Old and Huge Hiatal Hernia
Authors: Moufid Abdellah , Sekkat Hamza , Skalli Leila Dahbi , Bakali Younes , Alaoui MounaMhamdi , Sabbah Farid , Hrora Abdelmalek , Raiss Mohammed
Published: April 2023

The combination of gastric tumor and hiatal hernia is a rare event, that makes management delicate, and the prognosis pejorative given the risk of multidirectional lymphatic dissemination. Through this case report, we present a fully laparoscopic management, in an 80-year-old woman with a gastric tumor of the upper 1⁄3 of the stomach, associated with a huge hiatal hernia. This lady presented to the emergencies during the period of the Covid 19 pandemic, for dyspnea crisis of progressive worsening. thoraco-abdominopelvic CT showed a huge hiatal hernia explaining its symptomatology. Esogastroduodenal fibroscopy showed a cardia-gastric tumor. A total laparoscopy gastrectomy with lymph node dissection D1.5 associated with a cure of hiatal hernia were performed. The postoperative follow-up was simple and the patient declared outgoing on Day 5 postoperative.
An Outstanding Rapid Clinical Response to Olaparib in A Patient with gBRCA2m Fungating Breast Cancer: A Case Report
Authors: Chelal Aref , Ahmed Rayan , Jamali Faek El , Silymon Deepthi , Almehrezi Abdulla , Syed Naveed , Uttamchandani Ashok , Alakkad Ashraf
Published: April 2023

Background: Breast cancer is a heterogeneous, phenotypically complex disease made up of various biologic subgroups with unique behaviors and therapeutic responses. Noted that despite lack of a cure for metastatic breast cancer (MBC), there have been appreciable advancements in survival that have occurred at the same time as newer systemic treatments. BRCA1 or BRCA2 mutations cause homologous recombination deficient (HRD) cells, which are vulnerable to PARPi agent treatment. Case Report: This case report presents a 40 years old single female, known case of multiple co-morbidities who was diagnosed with Bilateral breast cancer in June 2022. She has a Positive family history of malignancy; mother died from endometrial cancer and aunt from paternal side has breast cancer. She underwent needle core biopsy from her Right breast mass, which revealed Invasive high-grade ductal carcinoma with metaplastic features (foci of keratinizing squamous differentiation, and myxoid stromal change). DCIS, of intermediate and high grades and a solid pattern, was noted, focally suspicious for lymphovascular invasion, Triple negative (ER negative (<1%), PR negative (<1%) and her-2 (+2) FISH negative (Her-2 Low), KI 67= 70%. Left breast mass Biopsy done on 12/9/2022 showed Invasive Lobular carcinoma, grade 3, ER negative, PR negative, Her-2 +1, KI 67=70%, BRCA2 POSITIVE & PDL1 CPS score 10%. Staging positron emission tomography scan done on 10 October 2022. She had a Large hypermetabolic fungating right breast mass infiltrating the chest wall, consistent with biopsy-proven malignancy. Additional smaller FDG-avid lesions noted in the right breast. Moreover, she had FDG-avid right axillary and right internal mammary nodal metastases. Mildly FDG-avid left breast mass, consistent with biopsy-proven malignancy. FDG-avid liver and pleural metastases. She was started on PARP inhibitor (Olaparib) on 20/9/2022 after which she had amazing fast clinical response leading to falling off the large fungating mass. Conclusion: The chance of developing breast and ovarian cancer is extremely elevated if one possesses BRAC 1 or BRCA 2 mutation. In this situation, PARP inhibitors, mutation-targeted therapy, has better outcomes in reducing the morbidity and mortality associated with metastatic breast cancer (Olaparib).
Antígeno del factor von Willebrand (FVW:Ag)/ Actividad del cofactor de ristocetina (FVW:RCo)/ Multímeros de factor von Willebrand
Authors: Vizcaíno-Carruyo Jennifer C. , Pérez-Monterrosa María Elena , Toro-Montoya Ana Isabel , Franco-Alzate Catalina
Published: April 2023

La utilidad principal de la prueba antígeno del FVW (FVW:Ag) es diagnosticar la enfermedad de von Willebrand (EVW), la cual es un trastorno hemorrágico causado por una reducción o alteración cualitativa del FVW, que puede ser hereditario en la mayoría de los casos, o adquirido cuando es secundario a otras patologías. Por su parte, la prueba FVW:RCo mide la capacidad del FVW de aglutinar plaquetas exógenas normales fijadas en formaldehído, ante la presencia del cofactor antibiótico ristocetina. La cantidad de aglutinación inducida por la ristocetina está directamente relacionada con la concentración del FVW, y se determina como porcentaje de actividad a través de un agregómetro. Finalmente, la prueba de multímeros de factor von Willebrand  se basa en la técnica de electroforesis e inmunofijación en gel de agarosa, que permite evaluar la distribución y presencia de los multímeros del FVW en el plasma de acuerdo a su peso molecular. En el gel, los multímeros son separados e inmunoprecipitados con un antisuero específico anti-FVW. La utilización de un anticuerpo marcado con peroxidasa y un substrato específico, hace que se puedan visualizar las diferentes bandas en el gel.
Awareness of Ischemic Stroke among Physicians in Primary Care and Emergency Departments
Authors: Gesoglu Demir Tulin , Ethemoglu Ozlem , Agircan Dilek , Demir Huseyin Avni
Published: April 2023

Objective: In particular, ischemic stroke is the primary cause of disability and loss of work force. With intravenous thrombolytic therapy and/or mechanical thrombectomy, stroke is a curable disease. In this study, we evaluated the ischemic stroke awareness of physicians who had first contact with stroke patients.
Material and Methods: An online questionnaire of 20 items was applied to collect data. Participation was voluntary, resulting in 66 family physicians and 87 general practitioners.
Results: 92.4% of family physicians and 90.8% of general practitioners responded correctly to the item that deals with ischemic stroke symptoms. In the item related to the duration of thrombolytic therapy, the rate of correct response of general practitioners was significantly higher than that of family physicians (p< 0.05). Physicians who worked in the profession for less than 5 years had a significantly higher rate of correct answers than those who worked in the profession for more than 5 years.
Conclusion: Today, awareness of family physicians working in primary care and physicians working in emergency services who are in first contact with paralyzed patients should be increased. In addition, patient diagnosis and referral should be focused on. For this purpose, primary care physicians' knowledge on ischemic stroke should be increased. Training should be expanded to raise the awareness of physicians about new developments in stroke prevention, diagnosis and treatment.
Distribution and antifungal resistance rate of yeast isolated from various samples
Authors: Özbek Erdal , Bagi Azarkan Ayşe , Temiz Hakan , Atmaca Selehattin
Published: April 2023

Objective: Yeast causes hospital-acquired infections at increasing rates, which can cause serious mortality, especially in patients with a suppressed immune system. This study aimed to determine the species distribution and antifungal resistance rates of yeast isolated in a hospital.
Material and Methods: Isolated yeasts from clinical specimens of patients who received inpatient treatment in different clinics in our hospital between 1 December 2019 and 30 September 2020 were examined. In all of these isolates, species identification was made with an automated system in addition to classical methods. Additionally, the antifungal susceptibility of yeast against amphotericin B, flucytosine, Fluconazole, micafungin, caspofungin, and Voriconazole was investigated using an automated system.
Results: In the study, yeasts isolated from 183 clinical samples, including 64 vagen, 62 blood, 28 urine, 12 wounds, eight tracheal aspirates, five peritoneal fluids, three catheters and one cerebrospinal fluid (CSF) samples were included. Of these isolates, 93 were Candida albicans (50,82%), 40 were Candida parapsilosis (21,86%), 17 were Candida tropicalis (9,29%), eight were Candida glabrata (4,37%), eight were  Stephanoascus ciferrii (4,37%), five were Candida lusitaniae (2,19%), four were Candida famata (2,19%), four were Cryptococcus laurentii (2,19%) and four were Candida krusei ( 2,19%). Antifungal susceptibility testing was performed in 103 of the isolates. The highest resistance was found against Fluconazole, with 16.8%, and the lowest resistance was against flucytosine, with 2.2%. Antifungal resistance rates of Fluconazole, Voriconazole, amphotericin B, flucytosine, caspofungin and micafungin were found as 16.8%, 8.2%, 6.1%, 2.2%, 2.9% and 6.8% respectively.
Conclusion: Due to the increasing frequency of fungal infections due to long-term hospitalization, it has been concluded that identifying the causative species and reporting the antifungal susceptibility status is important in monitoring the change in resistance rates and guiding the treatment.
The role of macrophages, myeloperoxidase, interleukins IL-12, IL-13 in the formation of bronchial response to hyperosmolar stimulus in patients with bronchial asthma
Authors: Pirogov A. B. , Prikhodko A. G.
Published: April 2023

Introduction.The involvement of macrophages in the realization of oxidative / halogenating stress andthe role of macrophage populations in maintaining the balance of Th1/Th2 cytokines in patients with asthma with osmotic types of bronchial hyperresponsiveness has not been sufficiently studied.

Aim.To study the role of macrophages, myeloperoxidase (MPO), IL-12, IL-13 in the formation of the bronchial response to the hyperosmolar trigger in patients with asthma.

Materials and methods. The object of the study was asthma patients (n=35). The level of asthma control (Asthma Control Test, points), cellular composition (%) and MPO (pixel) of induced sputum (IS), bronchial response (ΔFEV1IHS, %) after 3-minute ultrasonic inhalation of hypertonic (4.5% NaCl) solution (IHS) were assessed. Before and after the IHS test, exhaled air condensate was collected, in which the concentration of IL-12, IL-12 (pg/mL) was determined.

Results.Patients with asthma did not control the disease, ACT was 14 (11; 16.5) points. Group 1 (n=15) included individuals with bronchial hyperresponsiveness to the IHS, group 2 (n=20) included patients with lack of it (ΔFEV1IHS-19.8±1.9 and 1.43±0.72%, respectively, p<0.001). Baseline FEV1 in groups 1 and 2 was 89.5±2.8 and 93.7±2.3%, respectively (p>0.05). The percentage of sputum macrophages in group 1 was lower (40 [15.95; 50.75]%), and the average cytochemical coefficient in phagocytes was higher (141.4±9.7) than in group 2 (50 [42.5; 63.6]; p=0.039 and 98.8±12.3; p=0.013, respectively). IL-12 expression was to be more significant than IL-13 expression in the initiation of airway inflammation and hyperresponsiveness to hyperosmolar stimulus.

Conclusion.The lower concentration of macrophages in the bronchi of asthma patients with airway hyperresponsiveness to hyperosmolar stimulus is most likely due to an increase in the secretory function of cells. A high level of MPO activity in these patients depended on the peroxidase function of secreting macrophages, was associated with M1 polarization of macrophages, and indicated a Th1 immune response associated with the participation of IL-12 in the regulation of airway hyperresponsiveness to a hypertonic trigger.