bluuebunny/crossref_metadata_2025 huggingface dataset:
Experimental demonstration of low signal-to-noise ratio matched field processing with a geoacoustic model extracted from noise
Authors: Hunter Akins F. , Kuperman W. A.
Published: May 2023

Passive localization of a low signal-to-noise ratio (SNR) source in a shallow water waveguide without prior geoacoustic information is accomplished by combining the mode-extraction method modal-MUSIC (multiple signal classification) with range-coherent matched field processing (MFP). Range-coherent MFP coherently combines snapshots from different resolution cells to obtain gain over noise. Modal-MUSIC uses knowledge of the water column sound speed profile (no bottom information) to extract noisy estimates of modal wavenumbers from ship noise recorded on a partially spanning vertical line array (VLA). A geoacoustic model is then fit to the wavenumber estimates extracted from noise with modal-MUSIC and used to compute replicas for range-coherent MFP. The combination of these two methods applied to a 21-element VLA achieves successful source localization at SNR levels as low as −20 dB using ten tonals transmitted during the SWellEx96 experiment.
Rheological signatures of a glass-glass transition in an aging colloidal clay
Authors: Angelini Roberta , Larobina Domenico , Ruzicka Barbara , Greco Francesco , Pastore Raffaele
Published: May 2023

The occurrence of non-equilibrium transitions between arrested states has recently emerged as an intriguing issue in the field of soft glassy materials. The existence of one such transition has been suggested for aging colloidal clays (Laponite® suspensions) at a weight concentration of 3.0%, although further experimental evidences are necessary to validate this scenario. Here, we test the occurrence of this transition for spontaneously aged (non-rejuvenated) samples by exploiting the rheological tools of dynamical mechanical analysis. On imposing consecutive compression cycles to differently aged clay suspensions, we find that quite an abrupt change of rheological parameters occurs for ages around three days. For Young’s and elastic moduli, the change with the waiting time is essentially independent from the deformation rate, whereas other “fluid-like” properties, such as the loss modulus, do clearly display some rate dependence. We also show that the crossover identified by rheology coincides with deviations of the relaxation time (obtained through x-ray photon correlation spectroscopy) from its expected monotonic increase with aging. Thus, our results robustly support the existence of a glass-glass transition in aging colloidal clays, highlighting characteristic features of their viscoelastic behavior.
Cryo-Electron Microscopy Structure of theMycobacterium tuberculosis Cytochromebcc:aa3Supercomplex and a Novel Inhibitor Targeting Subunit CytochromecI
Authors: Mathiyazakan Vikneswaran , Wong Chui-Fann , Harikishore Amaravadhi , Pethe Kevin , Grüber Gerhard
Published: May 2023

The mycobacterial cytochromebcc:aa3complex deserves the name “supercomplex” since it combines three cytochrome oxidases—cytochromebc, cytochromec, and cytochromeaa3—into one supramolecular machine and performs electron transfer for the reduction of oxygen to water and proton transport to generate the proton motive force for ATP synthesis. Thus, thebcc:aa3complex represents a valid drug target forMycobacterium tuberculosisinfections.
CRISPR Interference-Based Inhibition of MAB_0055c Expression Alters Drug Sensitivity in Mycobacterium abscessus
Authors: Nguyen Thanh Quang , Heo Bo Eun , Park Yujin , Jeon Seunghyeon , Choudhary Arunima , Moon Cheol , Jang Jichan
Published: May 2023

In this study, we utilized CRISPR interference (CRISPRi) to specifically target the
MAB_0055c
gene in
M. abscessus
, a bacterium that causes difficult-to-treat infections. The study found that silencing the gene lead to increased rifabutin and rifalazil susceptibility.
Identification by High-Throughput Real-Time PCR of 30 Major Circulating Listeria monocytogenes Clonal Complexes in Europe
Authors: Félix Benjamin , Capitaine Karine , Te Sandrine , Felten Arnaud , Gillot Guillaume , Feurer Carole , van den Bosch Tijs , Torresi Marina , Sréterné Lancz Zsuzsanna , Delannoy Sabine , Brauge Thomas , Midelet Graziella , Leblanc Jean-Charles , Roussel Sophie
Published: May 2023

Multilocus sequence typing (MLST) is the reference method for
Listeria monocytogenes
typing but is expensive and takes time to perform, from 3 to 5 days for laboratories that outsource sequencing. Thirty major MLST clonal complexes (CCs) are circulating in the food chain and are currently identifiable only by sequencing.
Genome-Wide Characterization of the RNA Exosome Complex in Relation to Growth, Development, and Pathogenicity of Fusarium graminearum
Authors: Yuan Yanping , Mao Xuzhao , Abubakar Yakubu Saddeeq , Zheng Wenhui , Wang Zonghua , Zhou Jie , Zheng Huawei
Published: May 2023

The RNA exosome complex is the most versatile RNA degradation machinery in eukaryotes. However, little is known about how this complex regulates the development and pathogenicity of plant-pathogenic fungi.
Supplemental Material: Wet calc-alkaline magmatic fractionation in the middle–upper crustal sections of the continental arc: Insights from the Neoproterozoic Nanba intrusive complex, western Yangtze Block, South China
Authors: Zhu Yu , et al.
Published: May 2023

 Figure S1: Field outcrops for the Nanba intrusive complex along the western Yangtze Block, South China. Figure S2: Cathodoluminescence (CL) images of representative zircons of the different lithologies in the Neoproterozoic Nanba intrusive complex of the western Yangtze Block, South China. Figure S3: Laser ablation–inductively coupled plasma–mass spectrometry (LA-ICP-MS) zircon U-Pb concordia diagrams for the different lithologies in the Neoproterozoic Nanba intrusive complex of the western Yangtze Block, South China. Figure S4: Photomicrographs show the polycrystalline aggregate of feldspar phases in the K-feldspar granites in the Neoproterozoic Nanba intrusive complex of the western Yangtze Block, South China. Supplemental Data S1: A summary of Neoproterozoic igneous rocks of the western Yangtze Block, South China. Supplemental Data S2: Representative electron probe analyses of feldspar from the Neoproterozoic Nanba intrusive complex of the western Yangtze Block, South China. Supplemental Data S3: Representative electron probe analyses of hornblende from the Neoproterozoic Nanba intrusive complex of the western Yangtze Block, South China. Supplemental Data S4: LA-ICP-MS zircon U-Pb dating results for the Neoproterozoic Nanba intrusive complex of the western Yangtze Block, South China. Supplemental Data S5: Zircon Lu-Hf isotopic data of the Neoproterozoic Nanba intrusive complex of the western Yangtze Block, South China. Supplemental Data S6: The whole-rock major (wt%) and trace (ppm) elements for the Neoproterozoic Nanba intrusive complex of the western Yangtze Block, South China. 
Phase II study of nivolumab and salvage nivolumab/ipilimumab in treatment-naïve patients with advanced non-clear cell renal cell carcinoma (HCRN GU16-260-Cohort B)
Authors: Atkins Michael B , Jegede Opeyemi A , Haas Naomi B , McDermott David F , Bilen Mehmet A , Stein Mark , Sosman Jeffrey A , Alter Robert , Plimack Elizabeth R , Ornstein Moshe C , Hurwitz Michael , Peace David J , Signoretti Sabina , Denize Thomas , Cimadamore Alessia , Wu Catherine J , Braun David , Einstein David , Catalano Paul J , Hammers Hans
Published: May 2023

Background

To determine the efficacy and toxicity of nivolumab monotherapy in treatment-naïve patients with non-clear cell renal cell carcinoma (nccRCC) and the efficacy of nivolumab/ipilimumab salvage therapy in patients with tumors unresponsive to initial nivolumab monotherapy.

Methods

Eligible patients with treatment-naïve nccRCC received nivolumab until progressive disease (PD), toxicity, or completion of 96 weeks of treatment (Part A). Patients with PD prior to, or stable disease (SD) at 48 weeks (prolonged SD) were potentially eligible to receive salvage nivolumab/ipilimumab (Part B). Patients were required to submit tissue from a metastatic lesion obtained within 12 months prior to study entry and prior to Part B for correlative studies.

Results

35 patients with nccRCC were enrolled: 19 (54%) had papillary, 6 (17%) had chromophobe and 10 (29%) had unclassified histology. At median follow-up of 22.9 months, RECIST-defined objective response rate (ORR) was 5 of 35 (14.3% 95% CI 4.8% to 30.3%) (complete response (CR) 2 (5.7%) and partial response (PR) 3 (8.6%)). ORR by histology was: papillary—1/19 (5%); chromophobe—1/6 (17%); and unclassified—3/10 (30%). Nine patients (26%) had tumors with sarcomatoid features with 3 (33%) (2 unclassified and 1 papillary) responding. ORR was 0/18, 3/11 (27%) and 2/6 (33%) for patients with tumor progammed death ligand 1 (PD-L1) expression of <5%, ≥5% or not measured, respectively. Median progression-free survival was 4.0 (2.7–4.3) months. Two of five responders have progressed. Thirty-two patients had PD or prolonged SD and therefore, were potentially eligible for salvage nivolumab/ipilimumab (Part B), but 15 patients did not enroll due to grade 2–3 toxicity (6) on nivolumab, symptomatic disease progression (5), or other reasons including no biopsy tissue (4). In the 17 Part B patients, there was one PR (6%) (unclassified/non-sarcomatoid). Grade>3 treatment-related adverse events were seen in 7/35 (20%) on nivolumab and 7/17 (41%) on salvage nivolumab/ipilimumab with one patient experiencing sudden death.

Conclusions

Nivolumab monotherapy has limited activity in treatment-naïve nccRCC with most responses (4 of 5) seen in patients with sarcomatoid and/or unclassified tumors. Toxicity is consistent with prior nivolumab studies. Salvage treatment with nivolumab/ipilimumab was provided in half of these patients with minimal activity.

Trial registration number

NCT03117309.
Cross-anisotropic stiffness characteristics of a compacted lateritic clay from very small to large strains
Authors: Bentil O.T. , Zhou C. , Zhang Jun-hui , Liu K.
Published: May 2023

Lateritic clay is widely distributed in tropical and subtropic regions, with distinct engineering properties from other clays. Its stiffness properties, which are often anisotropic and crucial for analysing the serviceability limit state of earthen structures, have not been well understood. This study investigated the cross-anisotropic stiffness of compacted lateritic clay through comprehensive isotropic compression and consolidated drained and undrained shear tests. Both vertically and horizontally cut specimens were tested using triaxial apparatus equipped with bender elements and local strain measurements. The results show that compared with other clays, the lateritic clay shows a weaker dependency of shear modulus to confining pressure, a higher shear modulus at the same confining pressure, and a higher degradation rate of stiffness with strain. The lateritic clay behaves like granular material due to its large-size aggregated microstructure and 42% sand content. The widely used correlations between stiffness parameters and plasticity index seem unsuitable for it. Furthermore, the elastic shear modulus in the vertical direction is slightly higher than that in the horizontal direction, and the anisotropy evolves during shearing. A complete set of cross-anisotropic stiffness parameters for both effective and total stress analysis were determined. They are useful for developing constitutive models and analysing earth structures' serviceability involving lateritic soils.
On 1 + 3 covariant perturbations of the quasi-Newtonian spacetime in modified Gauss–Bonnet gravity
Authors: Munyeshyaka Albert , Ntahompagaze Joseph , Mutabazi Tom , Mbonye Manasse R.
Published: May 2023

The consideration of a [Formula: see text] covariant approach to cold dark matter universe with no shear cosmological dust model with irrotational flows is developed in the context of [Formula: see text] gravity theory in this study. This approach reveals the existence of integrability conditions which do not appear in noncovariant treatments. We constructed the integrability conditions in modified Gauss–Bonnet [Formula: see text] gravity basing on the constraints and propagation equations. These integrability conditions reveal the linearized silent nature of quasi-Newtonian models in [Formula: see text] gravity. Finally, the linear equations for the overdensity and velocity perturbations of the quasi-Newtonian spacetime were constructed in the context of modified [Formula: see text] gravity. The application of harmonic decomposition and redshift transformation techniques to explore the behavior of the overdensity and velocity perturbations using [Formula: see text] model was made. On the other hand, we applied the quasi-static approximation to study the approximated solutions on small scales which helps to get both analytical and numerical results of the perturbation equations. The analysis of the energy overdensity and velocity perturbations for both short- and long-wavelength modes in a dust-Gauss–Bonnet fluids was done and we see that both energy overdensity and velocity perturbations decay with redshift for both modes. In the limits to [Formula: see text]CDM, it means [Formula: see text] the considered [Formula: see text] model results coincide with [Formula: see text]CDM.
MATHEMATICAL MODELING OF INFECTION MECHANISM BETWEEN MILD AND SEVERE COVID-19 PATIENTS
Authors: LAN QING , WU HUI , LOU JIE , LI JIANQUAN
Published: May 2023

The SARS-CoV-2 leads to a worldwide COVID-19 pandemic, which has caused tremendous damage to the world. In this paper, we develop a dynamic model in vivo, fitting and estimating parameters for T lymphocytes and pro-inflammatory cytokines IL-6 in patients with mild and severe COVID-19 at Yale New Haven Hospital through the GWMCMC algorithm. Meanwhile, we also analyze the structural identifiability and practical identifiability of the model. Further, we add time-varying parameters to the model, using the least squares method to perform data fitting and parameter estimation on survivors and non-survivors of the Italian infectious disease hospital. Then analyze the similarities and differences in immune response mechanisms between the two countries. Finally, we demonstrate the existence and stability of the equilibrium state of the model and analyze the Hopf bifurcation at the positive equilibrium state by using the central manifold theory and normal form theory. This result may explain the recurrence of infection in some COVID-19 patients.
An Efficient and Multi-Tier Node Deployment Strategy Using Variable Tangent Search in an IOT-Fog Environment
Authors: Sravanthi Gunaganti , Moparthi Nageswara Rao
Published: May 2023

The Internet of Things (IoT) creates a large number of datasets, and these are handled in cloud data centers. IoT services are more delayed when data is sent over longer distances to the cloud. Node deployment is used to improve the performance of the multi-tier IoT-Fog environment by finding minimum distance with low Latency. Several methods have been discussed previously to improve the node deployment strategies but they do not provide good results. To overcome these issues, an Efficient and Multi-Tier Node Deployment Strategy using Variable Tangent Search Optimization Algorithm (VTSOA) is proposed in an IoT-Fog Environment. This Multi-Tier Node Deployment Strategy consists of several layers: IoT device layer, Fog layer, and cloud layer. The IoT device layer collects the data from external devices and is transmitted to the Fog layer. The fog layer contains several nodes. Hence, it increases the Latency of sending the data to the cloud. Therefore, VTSOA-based node deployment is done in the fog layer which finds the minimum distance nodes for effective communication. In this, the proposed approach is implemented in MATLAB. After that, the performance of this method is linked to various optimization algorithms.
Virus-Derived Small RNAs and microRNAs in Health and Disease
Authors: Gouzouasis Vasileios , Tastsoglou Spyros , Giannakakis Antonis , Hatzigeorgiou Artemis G.
Published: May 2023

MicroRNAs (miRNAs) are short noncoding RNAs that can regulate all steps of gene expression (induction, transcription, and translation). Several virus families, primarily double-stranded DNA viruses, encode small RNAs (sRNAs), including miRNAs. These virus-derived miRNAs (v-miRNAs) help the virus evade the host's innate and adaptive immune system and maintain an environment of chronic latent infection. In this review, the functions of the sRNA-mediated virus–host interactions are highlighted, delineating their implication in chronic stress, inflammation, immunopathology, and disease. We provide insights into the latest viral RNA–based research—in silico approaches for functional characterization of v-miRNAs and other RNA types. The latest research can assist toward the identification of therapeutic targets to combat viral infections.
Emerging Time-Resolved X-Ray Diffraction Approaches for Protein Dynamics
Authors: Hekstra Doeke R.
Published: May 2023

Proteins guide the flows of information, energy, and matter that make life possible by accelerating transport and chemical reactions, by allosterically modulating these reactions, and by forming dynamic supramolecular assemblies. In these roles, conformational change underlies functional transitions. Time-resolved X-ray diffraction methods characterize these transitions either by directly triggering sequences of functionally important motions or, more broadly, by capturing the motions of which proteins are capable. To date, most successful have been experiments in which conformational change is triggered in light-dependent proteins. In this review, I emphasize emerging techniques that probe the dynamic basis of function in proteins lacking natively light-dependent transitions and speculate about extensions and further possibilities. In addition, I review how the weaker and more distributed signals in these data push the limits of the capabilities of analytical methods. Taken together, these new methods are beginning to establish a powerful paradigm for the study of the physics of protein function.
Quantitative Single-Molecule Localization Microscopy
Authors: Hugelier Siewert , Colosi P.L. , Lakadamyali Melike
Published: May 2023

Super-resolution fluorescence microscopy allows the investigation of cellular structures at nanoscale resolution using light. Current developments in super-resolution microscopy have focused on reliable quantification of the underlying biological data. In this review, we first describe the basic principles of super-resolution microscopy techniques such as stimulated emission depletion (STED) microscopy and single-molecule localization microscopy (SMLM), and then give a broad overview of methodological developments to quantify super-resolution data, particularly those geared toward SMLM data. We cover commonly used techniques such as spatial point pattern analysis, colocalization, and protein copy number quantification but also describe more advanced techniques such as structural modeling, single-particle tracking, and biosensing. Finally, we provide an outlook on exciting new research directions to which quantitative super-resolution microscopy might be applied.
Bringing Structure to Cell Biology with Cryo-Electron Tomography
Authors: Young Lindsey N. , Villa Elizabeth
Published: May 2023

Recent advances in cryo-electron microscopy have marked only the beginning of the potential of this technique. To bring structure into cell biology, the modality of cryo-electron tomography has fast developed into a bona fide in situ structural biology technique where structures are determined in their native environment, the cell. Nearly every step of the cryo-focused ion beam-assisted electron tomography (cryo-FIB-ET) workflow has been improved upon in the past decade, since the first windows were carved into cells, unveiling macromolecular networks in near-native conditions. By bridging structural and cell biology, cryo-FIB-ET is advancing our understanding of structure–function relationships in their native environment and becoming a tool for discovering new biology.
Machine Learning and the Digital Measurement of Psychological Health
Authors: Galatzer-Levy Isaac R. , Onnela Jukka-Pekka
Published: May 2023

Since its inception, the discipline of psychology has utilized empirical epistemology and mathematical methodologies to infer psychological functioning from direct observation. As new challenges and technological opportunities emerge, scientists are once again challenged to define measurement paradigms for psychological health and illness that solve novel problems and capitalize on new technological opportunities. In this review, we discuss the theoretical foundations of and scientific advances in remote sensor technology and machine learning models as they are applied to quantify psychological functioning, draw clinical inferences, and chart new directions in treatment.
Study on Fault Activation Evaluation Mechanism and Sensitivity Analysis in Shale Gas Hydraulic Fracturing
Authors: Liu Penglin , Fu Haifeng , Chen Zhuxing , Li Qixuan , Li Jun , Liu Jiayi , He Yu , Liu Xianbo
Published: May 2023

Shale gas hydraulic fracturing usually activates nearby faults and makes them slip. In horizontal wells, fault slip can result in serious casing deformation. Casing deformation slows the fracturing process, lowers production, and raises the cost of a shale gas well. It is challenging to obtain underground data on fault activation because of the deep shale reservoirs. As a result, the current study needed to indicate how hydraulic fracturing affects fault activation length. This made it challenging to control casing deformation. The fluid-structure coupled finite element method was used in this study to create a coupled seepage-stress model for heterogeneous shale formation. With microseismic signs and hydraulic fracking for shale gas, this model examined the variation law of pore pressure and ground stress. The fault activation coefficient was created to assess the fault activation duration and the impact of hydraulic fracturing. The model was verified by the microseismic signal. The outcomes of the numerical simulation demonstrate how the rapid rise in formation pore pressure during hydraulic fracturing affected the ground stress at the fault interface. The influence of ground stress variation at the fault interface on fault activation could not be ignored. Increased fault elastic modulus, fracture pressure, fracture time, and the fault Poisson ratio result in longer fault activation lengths. The length of the fault’s activation was decreased by the increase in fracture stage, distance from the fault, friction angle within the fault, and fault angle. Finally, a shale gas horizontal well with casing deformation in block C was analyzed. The results showed that reducing the fracturing duration can reduce the activation length of the fault by 68.25%, resulting in a 9.1 mm fault slide and a 0.86 mm casing deformation, respectively. This study offers theoretical guidelines for preventing fault activation during hydraulic fracturing in horizontal shale gas wells.
Role of Single Nucleotide Polymorphism‐Related Genes in Tumour Immune Cell Infiltration and Prognosis of Cutaneous Melanoma
Authors: Wang Baihe , Liu Fanxiao , Li Yuanyuan , Chen Nan
Published: May 2023

Background. Advances in cancer research have allowed for early diagnosis and improved treatment of cutaneous melanoma (CM). However, its invasiveness and recurrent metastasis, along with rising resistance to newer therapies, have lent urgency to the search for novel biomarkers and the underlying molecular mechanisms of CM. Methods. Single nucleotide polymorphism‐ (SNP‐) related genes were obtained from the sequencing data of 428 CM samples in The Cancer Genome Atlas. Functional enrichment of these genes was analysed in clusterProfiler. Additionally, a protein‐protein interaction (PPI) network was constructed with the Search Tool for the Retrieval of Interacting Gene (STRING) database. Gene Expression Profiling Interactive Analysis (GEPIA) was used to identify the expression and prognostic value of mutated genes. Finally, the Tumour Immune Estimation Resource (TIMER) analysed the relationship between gene expression and immune cell infiltration. Results. We constructed a PPI network from the top 60 SNP‐related genes. Mutated genes were mainly involved in calcium and oxytocin signalling pathways, as well as circadian entrainment. In addition, three SNP‐related genes, BRAF, FLG, and SORL1, were significantly associated with patient prognosis. BRAF and SORL1 were positively associated with infiltration abundance of B cells, CD8+ T cells, CD4+ T cells, neutrophils, and dendritic cells, whereas FLG expression was negatively associated. Furthermore, higher immune cell infiltration was positively correlated with good prognosis. Conclusions. Our study provides vital bioinformatic data and a relevant theoretical basis to further explore the molecular pathogenesis of CM and improve patient prognosis.
Experimental and Numerical Investigation of Integrated Steel Shear Walls with Varying Web Width-to-Thickness Ratios
Authors: Lee Doo-Yong , Cho Bong-Ho , Jung Dam-I.
Published: May 2023

The cold-formed steel-framed shear wall sheathed with steel sheet is widely used as a lateral force-resisting system for light-framed construction. However, the boundary conditions of the screw joint are not clear when steel is screwed to the frame. To address this issue, experimental methods have been used to calculate shear strength, but these methods have many limiting factors. In this study, we investigate the structural performance of integrated steel shear walls with varying web width-to-thickness ratios as an alternative to steel-sheathed shear walls used in light-gauge steel frames. The proposed design equation for cold-formed steel integrated shear walls is validated by three specimens and 72 finite element models. This equation allows designers to determine the strength of integrated steel shear walls without conducting full-scale shear-wall tests.
T‐Spherical 2‐Tuple Linguistic Aggregation Operators and Their Applications in the Decision‐Making Strategy
Authors: Mahmood Tahir , Ali Zeeshan , Awsar Amrullah
Published: May 2023

The decision‐making technique is very important and valuable and is used for evaluating the best decision from the collection of preferences. In this manuscript, we elaborated the novel concept of the T‐spherical 2‐tuple linguistic (TS2‐TL) set and its operational laws in the consideration of t‐norm and t‐conorm. The theory of the TS2‐TL set is more massively generalized than the fuzzy set and its extensions. Moreover, aggregating the collection of information into a singleton set is also a very challenging task for scholars; therefore, by using the TS2‐TL setting, we explored the TS2‐TL weighted averaging (TS2‐TLWA), TS2‐TL ordered weighted averaging (TS2‐TLOWA), TS2‐TL hybrid averaging (TS2‐TLHA), TS2‐TL weighted geometric (TS2‐TLWG), TS2‐TL ordered weighted geometric (TS2‐TLOWG), and TS2‐TL hybrid geometric (TS2‐TLHG) operators and described their important and dominant properties. The derived operators based on TS2‐TL information are the modified version of the averaging/geometric aggregation operators for fuzzy set and their extensions. Using the invented approaches, various specific terminologies are also diagnosed with the help of remarks. The elaborated operators are applied to determine and rank the manufacturing of small and medium‐sized enterprises (SMEs). Finally, we utilize the sensitive analysis of the exposed approaches with various existing drawbacks in the presence of many practical examples to expose the improvements, dominance, and graphical representations of utilized approaches.
The Effect of Adjuvant Radiotherapy on One- and Two-Stage Prosthetic Breast Reconstruction and on Autologous Reconstruction: A Multicenter Italian Study among 18 Senonetwork Breast Centres
Authors: Emanuele Lisa Andrea Vittorio , Salgarello Marzia , Huscher Alessandra , Corsi Fabio , Piovani Daniele , Rubbino Federica , Andreoletti Stefania , Papa Giovanni , Klinger Francesco , Tinterri Corrado , Testori Alberto , Scorsetti Marta , Veronesi Paolo , Leonardi Maria Cristina , Rietjens Mario , Cortinovis Umberto , Summo Valeria , Rampino Cordaro Emanuele , Parodi Pier Camillo , Persichetti Paolo , Barone Mauro , De Santis Giorgio , Murolo Matteo , Riccio Michele , Aquinati Angelica , Cavaliere Francesco , Vaia Nicola , Pagura Giulia , Dalla Venezia Erica , Bassetto Franco , Vindigni Vincenzo , Ciuffreda Luigi , Bocchiotti Maria Alessandra , Sciarillo Alberto , Renzi Nadia , Meneghini Graziano , Kraljic Tajna , Loreti Andrea , Fortunato Lucio , Pino Valentina , Vinci Valeriano , Klinger Marco
Published: May 2023

Purpose. In modern breast cancer treatment, a growing role has been observed for breast reconstruction together with an increase in clinical indications for postmastectomy radiotherapy (PMRT). Choosing the optimum type of reconstructive technique is a clinical challenge. We therefore conducted a national multicenter study to analyze the impact of PMRT on breast reconstruction. Methods. We conducted a retrospective case-control multicenter study on women undergoing breast reconstruction. Data were collected from 18 Italian Breast Centres and stored in a cumulative database which included the following: autologous reconstruction, direct-to-implant (DTI), and tissue expander/immediate (TE/I). For all patients, we described complications and surgical endpoints to complications such as reconstruction failure, explant, change in type of reconstruction, and reintervention. Results. From 2001 to April 2020, 3116 patients were evaluated. The risk for any complication was significantly increased in patients receiving PMRT (aOR, 1.73; 95% CI, 1.33–2.24;

p
<
0.001

). PMRT was associated with a significant increase in the risk of capsular contracture in the DTI and TE/I groups (aOR, 2.24; 95% CI, 1.57–3.20;

p
<
0.001

). Comparing type of procedures, the risk of failure (aOR, 1.82; 95% CI, 1.06–3.12,

p
=
0.030

), explant (aOR, 3.34; 95% CI, 3.85–7.83,

p
<
0.001

), and severe complications (aOR, 2.54; 95% CI, 1.88–3.43,

p
<
0.001

) were significantly higher in the group undergoing DTI reconstruction as compared to TE/I reconstruction. Conclusion. Our study confirms that autologous reconstruction is the procedure least impacted by PMRT, while DTI appears to be the most impacted by PMRT, when compared with TE/I which shows a lower rate of explant and reconstruction failure. The trial is registered with NCT04783818, and the date of registration is 1 March, 2021, retrospectively registered.
A Hybrid Quantum-Classical Algorithm for Underwater Target Classification
Authors: Wang Furong , Yang Fan , Li Yixing , Fan Gang , He Long , Liu Yang , Bai Yu , Zhang Ya
Published: May 2023

Offshore channel clearance is an essential underwater task to protect vessels and divers effectively, but current underwater target classification relies heavily on operator identification. Machine learning provides highly accurate methods for image classification as well as detection. In this paper, a new hybrid quantum-classical classification algorithm is proposed. It uses quantum devices to reduce dimension and denoise data sets, greatly reducing the difficulty of classical computer processing data. Using abundant classical classification algorithms, the classification problem of different scenarios can be processed, improving the classification efficiency. Using two kinds of underwater object data sets as examples, the numerical simulation results show that the quantum algorithm can accurately achieve dimensionality reduction. This hybrid algorithm has polynomial acceleration in dimension reduction than classical methods, even considering the classical readout of quantum data. The results also show that the classification accuracy of the training set improves from 0.772 to 0.821 compared to the original dataset. Furthermore, different classical classifiers can be selected in the case of different objects, so this hybrid algorithm has broad application prospects in different fields.
Vitamin B6 Deficiency Induces Autism-Like Behaviors in Rats by Regulating mTOR-Mediated Autophagy in the Hippocampus
Authors: Chen Lijuan , Li Jing , Liu Xinglian , Zhao Zhiwei , Jin Yan , Fu Yikun , Zhou Aiqin , Wang Chengqun , Zhou Yan
Published: May 2023

Vitamin B6 (VB6) exhibits therapeutic effects towards autism spectrum disorder (ASD), but its specific mechanism is poorly understood. Rat dams were treated with VB6 standard, VB6 deficiency, or VB6 supplementary diet, and the same treatment was provided to their offspring, with their body weights monitored. Three-chambered social test and open field test were employed to evaluate the effect of VB6 on autism-like behaviors. Gamma-aminobutyric acid (GABA) generation and synaptic inhibition of neurons in the hippocampus of rat were detected via immunofluorescence staining, followed by the measurement of GABA concentration through high-performance liquid chromatography (HPLC). The role of VB6 in the autophagy and apoptosis of cells was determined via Western blot and terminal deoxynucleotidyl transferase dUTP nick-end labeling (TUNEL). In order to conduct rescue experiments, the inhibition of mammalian target of rapamycin (mTOR) or the activation of GABA was achieved by drug administration to the offspring rats with VB6 deficiency. As a result, no evident difference in weight was observed in the offspring with varied VB6 treatments. VB6 deficiency impaired social interaction; aggravated self-grooming and bowel frequency; decreased GABA concentration, VIAAT, GAD67, vGAT expressions, and LC3 II/LC3 I ratio; increased p62 level and p-mTOR/mTOR ratio; and promoted cell apoptosis. Inhibition of mTOR reversed the effect of VB6 deficiency on cell autophagy. GABA activation or mTOR inhibition offset the role of VB6 deficiency in autism-like behaviors and hippocampal GABA expression. Collectively, VB6 deficiency induces autism-like behaviors in rats by regulating mTOR-mediated autophagy in the hippocampus.
Vegetation Structure and Tree Species Diversity inside and outside a Newly Established Zalon Taung National Park in Northwest Myanmar
Authors: Aye Tin Hnaung , Shibata Shozo
Published: May 2023

The Zalon Taung National Park (ZNP) in Banmauk township, northwest Myanmar, is a recently established protected area to protect the area’s cultural value, ecosystems, native flora, and wildlife. This research examined the vegetation structure, tree species diversity, and composition within (ZNP) and outside (the Banmauk unclassified forest (BUCF)) the park to inform conservation and resource utilization for sustainable management. We conducted the vegetation survey in April-May of 2022 by setting up 34 sample plots (40 × 40 meters) using a random sampling approach. We used stand density, basal area, Shannon–Wiener diversity index, Simpson index, Pielou's evenness, Fisher’s α diversity, and Importance Value Index (IVI) to determine the forest structure and tree diversity. A total of 116 tree species (≥10 cm·dbh), representing 87 genera and 48 families, were identified. The ZNP sample plots had a slightly higher stand density (201 individuals ha−1) and basal area (20.6 m2·ha−1) than BUCF (stand density: 191 individuals ha−1 and basal area: 15.0 m2·ha−1), which is accessible to collect firewood and timber extraction by residents. The reverse J-shaped pattern of the population structure indicated that the stands’ populations were progressive and healthy. BUCF featured the most Verbenaceae (12.9%) and the ZNP the most Euphorbiaceae (7.2%) families. Protium serratum had the highest IVI in the BUCF (26.91%) and Dipterocarpus alatus (18.39%) in the ZNP. Dipterocarpus alatus and Dalbergia oliveri (IUCN Red List-endangered species) dominate in BUCF and require special attention in conservation planning. In the ZNP, previous logging activity dramatically reduced the relative density and the IVI values of commercially important species such as Tectona grandis, Dalbergia oliveri, and Protium serratum. According to the NMDS ordination, differences in tree species compositions were significantly linked with elevation, the intensity of logging, and distance to the village and road. The results will help park managers plan effective land use to promote biodiversity conservation and local livelihoods.
Supplemental Table S3 from Phase II Investigation of TVB-2640 (Denifanstat) with Bevacizumab in Patients with First Relapse High-Grade Astrocytoma
Authors: Kelly William , Diaz Duque Adolfo Enrique , Michalek Joel , Konkel Brandon , Caflisch Laura , Chen Yidong , Pathuri Sarath Chand , Madhusudanannair-Kunnuparampil Vinu , Floyd John , Brenner Andrew
Published: May 2023

Exosome (50-120nm N=24) PFS Analysis Proportional Hazard Model with Adjustment for Study Arm
El lugar propio y la autonomía en jóvenes de barrios populares
Authors: Medan Marina
Published: May 2023

(analítico)Este artículo describe y analiza, desde una perspectiva etnográfica, las tramas de relaciones sociales que resultan significativas para jóvenes que habitan en barrios populares del Gran Buenos Aires (Argentina) y que participan de programas sociales. Estas tramas configuran el lugar —como posición social—, desde el cual construyen autonomía y dan cuenta de las condiciones de posibilidad de sus experiencias cotidianas. A partir de testimonios de jóvenes obtenidos mediante técnicas cualitativas entre 2016 y 2018, enfoco en la dimensión ética de las prácticas juveniles y en el modo en el que el género las marca. La autoridad parental, el peso de las miradas condenatorias y las formas de cuidado son analizados en relación a los usos de tiempos y espacios. Finalmente, señalo implicancias de los hallazgos para las políticas sociales.
Palabras clave:  Joven desfavorecido; vida cotidiana; política gubernamental; ética; Argentina; autonomía.
La batalla de las lenguas en la publicación nacional: un estudio comparativo de las publicaciones del CNPq (Brasil) y Conicet (Argentina)
Authors: Beigel Fernanda , Digiampietri Luciano
Published: May 2023

El predominio del inglés como lengua académica en las revistas de corriente principal ha sido profusamente estudiado. En cambio, es difícil calibrar la incidencia de la publicación en esteidioma en el mundo Iberoamericano porque son todavía escasos los  estudios de bases de datos regionales o de trayectorias académicas  completas de investigadores de los países del Sur global. Las razones son sencillas: a) hay múltiples bases de datos de revistas Iberoamericanas, pero con grandes solapamientos; y b) hay sistemas de currículo en la mayoría de los países, pero no están disponibles abiertamente o no están curadas profesionalmente. Precisamente para colaborar en esta dirección, este trabajo comparativo ofrece um panorama de las publicaciones completas de dos  comunidades científicas: los pesquisadores del Conselho Nacional de Pesquisa (CNPq, Brasil) y los investigadores del Consejo Nacional de Investigaciones Científicas y Técnicas (Conicet-Argentina). Para poner el foco en el idioma y el país de edición de la producción científica, utilizamos la información autocargada en el sistema curricular Sigeva (Argentina) y Lattes (Brasil). Su utilización ofrece dificultades a los estudios  bibliométricos o de citaciones, en cambio, permite construir una estadística descriptiva de la producción completa de itinerários completos de producción que es relevante para  frecer un panorama del  multilingüismo, la bibliodiversidady el peso de la publicación nacional en estas comunidades.
Documento e patrimônio entre usos e reflexões
Authors: Pereira Filho Hilario Figueiredo
Published: May 2023

O artigo problematiza os processos de atribuição de valor de patrimônio  cultural aos documentos históricos. Para isso, adota duas perspectivas  complementares: a noção alargada de fonte de pesquisa e seu exercício  constante de provocar reflexões, assim como destaca práticas mobilizadas em prol do reconhecimento dos acervos documentais como bens suscetíveis à patrimonialização. Com base em instrumentos acionados pelo campo  do patrimônio cultural – tombamento, declaração de interesse público e  s social e registro do Memória do  Mundo – destaca-se que os documentos podem ser apropriados  por olhares interdisciplinares.  Transformar a documentação histórica em patrimônio é, portanto, um processo de leitura crítica do próprio acervo documental.
Dissecando um “novo” mercado ilegal?
Authors: Ribeiro Ludmila
Published: May 2023

Resenha de Stolen Cars: A Journey Through São Paulo's Urban Conflict, John Wiley & Sons, London, 2021, de G. Feltran et al.
Sintonía afectiva entre políticos y usuarios de redes: el paro nacional en Colombia, 2021
Authors: Torralba Ángela Martínez , Guevara Juan Antonio , Hernández Ana María Córdoba , Robles-Morales José Manuel
Published: May 2023

Las redes sociales han generado una esfera pública híbrida con una creciente atención al papel de los sentimientos en el discurso público. Para los políticos, las redes son útiles al generar entornos de sentimientos individuales y colectivos, más que al dar razones y propiciar el diálogo público. El objetivo de esta  Investigación es analizar si existe sintonía afectiva entre los mensajesde líderes políticos y la respuesta que provocan en las redes. Para ello, se estudiaron los posts de los principales políticos colombianos, durante las manifestaciones del Paro Nacional, de 2021 y las reacciones emotivas que provocaron en Facebook. Tras el  Estudio, se comprobó la congruencia afectiva entre los mensajes y las reacciones y que el discurso público online se sustenta más en compartir criterios emotivos, que en una línea deliberativa racional.
On Eryphus Perty, 1832 (Dichophyiini), Eriphus Audinet-Serville, 1834 (Trachyderini, Trachyderina), and Eryphus Klug, 1829, with description of a new genus, and corrections on publication dates (Coleoptera, Cerambycidae)
Authors: Santos-Silva Antonio , Botero Juan Pablo , Nascimento Francisco Eriberto de Lima
Published: May 2023

The validity of two forgotten names, Eryphus Klug, 1829 and E. rubricollis Klug, 1829, is discussed. The former is considered a nomen oblitum and synonymized with Eriphus Audinet-Serville, 1834, a nomen protectum; the latter is revalidated and Eriphus purpuratus Chevrolat, 1862 is considered a junior synonym of Eriphus rubricollis (Klug, 1829). A lectotype is designated to Eryphus rubricollis Klug, 1829. The date of the work where Eriphus Audinet-Serville, 1834 was described is corrected. A new genus is described in Dichophyiini Gistel, 1848 to include the species currently allocated in Eryphus sensu Napp & Martins (2002). The dates of publication of genera and species described by Fairmaire & Germain (Révision des Coléoptères du Chili (suite)) are corrected.
Nomadismo extensivo versus nomadismo intensivo. Ciganos na Região Metropolitana de Vitória
Authors: Arruda Flávia Marcarine
Published: May 2023

Este é um artigo sobre a categoria analítica do nomadismo posto como objeto de crítica para repensar alguns de seus paradigmas como a conceituação dada no sentido comum que o descreve como um movimento extensivo de um deslocamento espacial constante. Essa conceituação será tensionada através das categorias ciganas relacionadas ao espaço, como pousar, andar, viajar, extraídas da etnografia que desenvolvi com uma rede de parentes de ciganos distribuídos na Região Metropolitana de Vitória do Estado do Espírito Santo. Para além do sentido comum, será possível apresentar a noção de um nomadismo intensivo, por meio das categorias ciganas em aproximação com o conceito de nomadismo de Deleuze e Guattari e do conceito de peregrinação e transporte empregado por Tim Ingold.
Por que Potlatch? Contribuições do Boletim de Informação da Internacional letrista para o estabelecimento de uma nova civilização
Authors: Vasconcellos Rachel Pacheco , Freire Thauany V. B. Pereira
Published: May 2023

Potlatch é o título do boletim de informação da Internacional Letrista, que circulou, a partir de Paris, seu centro de produção, entre 1954 e 1957. A I.L., tendo se formado enquanto ruptura de uma vanguarda artística (o letrismo de Isidore Isou), propõe em seu pequeno veículo práticas, formulações teóricas e críticas que darão mais tarde base à organização da Internacional Situacionista. Este artigo faz a análise deste material, buscando compreender a originalidade de seu posicionamento crítico em relação à arte, ao espaço urbano e a vida cotidiana, bem como do conteúdo político de suas ações e experimentações, direcionadas, antes de tudo, a explorar as possibilidades de superação das relações sociais de produção capitalistas.
O gosto do mundo. Exercícios de paisagem. Resenha do livro de Jean-Marc Besse
Authors: Lopes Ana Carolina Fróes Ribeiro
Published: May 2023

Jean-Marc Besse (França, 1956) é filósofo de formação. Possui interesse em epistemologia e história da ciência, e dedica-se, especialmente, aos temas da paisagem, do ambiente e da geografia. Em “O gosto do Mundo. Exercícios de Paisagem” (Ed. UERJ, 2014), Besse desenvolve uma reflexão sobre a paisagem de diferentes pontos de vista, apresentando problemáticas contemporâneas sobre o conceito de paisagem – atualmente compreendida dentro de uma complexa relação com o poder político e econômico e, particularmente, com o projeto urbano e a concepção da cidade.
Contra o funcionalismo
Authors: Jorn Asger , Lima Rodrigo Nogueira , Reis Tatiana Francischini Brandão dos , Negrelos Eulalia Portela , Andrade Carlos Roberto Monteiro de
Published: May 2023

O presente artigo analisa a relação entre a deriva situacionista e certas práticas artísticas contemporâneas as quais tem como princípio comum o andar como prática estética. O objetivo não é discutir o valor das experiências artísticas que se reivindicam da deriva situacionista, ou que são relacionadas ao ideário da Internacional Situacionista pela crítica, mas esclarecer a origem e os princípios que animaram os jovens letristas e situacionistas em suas incursões urbanas.
Delírios ambulatórios e derivas urbanas
Authors: Jacques Paola Berenstein
Published: May 2023

O artigo analisa as errâncias pelo grande labirinto realizadas por Hélio Oiticica (HO) e sua noção de Delirium Ambulatorium, próxima à concepção de deriva urbana dos situacionistas. Tendo em vista a não separação entre vida e obra em HO, bem como entre questões urbanas e corporais, o texto discute os vínculos entre corpo e ambiente nos diversos trabalhos de HO, dos parangolés a Tropicália. Retomando a noção de deriva e a psicogeografia desde os letristas, o artigo aponta o diálogo entre ideias situacionistas e tropicalistas.
Semiótica, fotografia e justiça social: um estudo na fronteira entre Semiótica da Fotografia e Semiótica do Direito
Authors: Bittar Eduardo Carlos Bianca
Published: May 2023

Este artigo desenvolve uma análise semiótica da fotografia, discutindo o seu valor para o debate público, a sensibilização e a mobilização da opinião pública e a luta por justiça social. A proposta de análise procura seguir na linha estreita das fronteiras da Semiótica da Fotografia e da Semiótica do Direito, de forma a aproximar dois campos de trabalho que têm sido muito pouco explorados, ao menos dentro da perspectiva teórica da semiótica greimasiana. A fotografia é analisada como texto fotográfico, inserida em narrativas culturais, de modo a estabilizar a imagem fotográfica, mobilizadora de sentidos sócioculturais que, quando tematizam questões de justiça, são capazes de afetar outros discursos. Ao gerar a afetação de mentalidades, a imagem tem o poder de persuasão, gerando um ciclo favorável à implementação de políticas e ações concernentes a novos direitos. É dessa forma que o texto fotográfico influencia, direta ou indiretamente, na  afirmação da justiça social e, por isso, pode estar na gênese do texto jurídico.