bluuebunny/crossref_metadata_2025 huggingface dataset:
Ko Wai Mātou
Authors:   , Wainohu Tiniwai
Published: January 2024

Landscapes are an integral component for the identity of people. The Māori people express an interconnectedness between land and people that form one's identity. Mātauranga Māori; the traditional indigenous knowledge of the Maori people originates from the natural world (Te Taiao), where mountains, rivers, lakes, forests and place are essential within Māori identity (Turangawaewae).

Since the first British ships arrived at Aotearoa/New Zealand, traditional Māori knowledge has degraded in both theory and practice due to the ongoing dominance of western society. Western development continuously degrades the health of the natural environment. Forests and waterways to this day are cleared and buried for the urban expansion of modern cities. This constant alteration of the natural landscape diminishes the cultural connection Māori once had with the natural landscape and is only becoming scarcer with time.

Mātauranga Māori is slowly growing within the landscape architecture field as a progressive way forward to honour Te Tiriti o Waitangi. Throughout this research Māori knowledge is used to facilitate an innovative approach in representing Māori values within landscape architecture design. Māori focused frameworks and methods are investigated to provide a strong connection between Māori principles and the natural landscape. It is with intention that the design framework within this study can be replicated and aid designers with clarity regarding Māori representation.

Running its course below the urban infrastructure of Wellington City, Waimapihi Stream was once rich in resources for the local lwi (Tribe) of Te Whanganui a Tara (Wellington) before being buried over a century ago due to the demand of settler development. The Waimapihi stream still holds a significant amount of cultural value to the local lwi of Te Whanganui a Tara and this research will look at opportunities to represent this cultural significance through landscape design and Mātauranga Māori led frameworks to increase the awareness and importance of this buried waterway.

This design-led research investigates Mātauranga Māori design principles and multifunctional green and blue spaces to reclaim Waimapihi as an important part of Wellington's dense urban landscape. It does that by approaching the waterway with a case study research and investigation of the pre-colonial past and bi-cultural relationship of Aotearoa {New Zealand). It finds that by reinstating Wellington's pre-colonial past within a colonial urban environment will provide cultural connection to the natural landscape within an otherwise unrepresented urban sprawl while providing the wider Wellington communities with the health and well-being benefits derived from green and blue infrastructure.
Apresentação
Authors: Pereira da Silva Cleber de Deus
Published: January 2024

Apresentação
Pemanfaatan Teknologi Informasi Dan Sistem Pengendalian Intern Terhadap Pengelolaan Alokasi Dana Desa (Studi Kasus Kecamatan Boliyohuto Kabupaten Gorontalo)
Authors: DITA FARA , Niswatin Dr. , - Usman
Published: January 2024

Tujuan dari penelitian ini adalah untuk mengetahui Pemanfaatan Teknologi Informasi dan Sistem Pengendalian Intern berpengaruh terhadap Pengelolaan Alokasi Dana Desa Di Kecamatan Boliyohuto Kabupaten Gorontalo.Jenis metode yang digunakan dalam penelitian ini adalah metode kuantitatif dengan teknik pengumpulan data menggunakan survey kuesioner. Adapun jumlah responden dalam penelitian ini sebanyak 52 responden yang terdiri dari Kepada Desa, Sekretaris Desa, Bendahara Desa, dan Badan Permusyawaratan Desa di seluruh Kecamatan Boliyohuto Kabupaten Gorontalo. Teknik analisis data dalam penelitian ini adalah analisis kuantitatif deskriptif dengan menggunakan uji t statistik, uji f statistik, dan uji koefisien determinasi (R Square) dengan menggunakan IBMSPSS 16 for windows. Berdasarkan hasil penelitian menunjukkan bahwa Pemanfaatan Teknologi Informasi berpengaruh secara persial senilai 58.9%, dan Sistem Pengendalian Intern berpengaruh secara persial sebesar 58.5%. kemudian secara simultan Pemanfaatan Teknologi Informasi dan Sistem Pengendalian Intern berpengaruh positif dan signifikan terhadap Pengelolaan Alokasi Dana Desa di kecamatan Boliyohuto Kabupaten Gorontalo dengan nilai determinan sebesar 56.4% sedangkan sisanya sebesar 43.6% dijelaskan oleh variabel lain yang tidak diteliti dalam penelitian ini. Kata Kunci: Pemanfaatan Teknologi Informasi, Sistem Pengendalian Intern Pengelolaan Dana Desa Klafisikasi JEL : M4
Pengaruh tax avoidance, leverage, dan ukuran perusahaan terhadap kinerja perusahaan
Authors: Fitriani Margareta , Gunarso Pujo , Dewi Any Rustia
Published: January 2024

Company performance is an achievement attained by the company during a specific time period that reflects the company's level of soundness. Company performance can be used as a measuring tool in assessing business success, as well as a factor in future decision making and planning. The study's goal is to examine the impact of tax avoidance, leverage, and company size on company performance. Purposive sampling was used in this study, which was conducted at a food and beverage company. According to the findings of this study, tax evasion has a negative impact on company performance. Leverage has a positive impact on business performance. The size of a company has a negative impact on its performance
Time trends and modifiable factors of COVID-19 contact tracing coverage, Geneva, Switzerland, June 2020 to February 2022
Authors: Mongin Denis , Bürgisser Nils ,   the Covid-SMC Study Group, Courvoisier Delphine Sophie
Published: January 2024

Background

Contact tracing was one of the central non-pharmaceutical interventions implemented worldwide to control the spread of SARS-CoV-2, but its effectiveness depends on its ability to detect contacts.

Aim

Evaluate the proportion of secondary infections captured by the contact tracing system in Geneva.

Methods

We analysed 166,892 concomitant infections occurring at the same given address from June 2020 until February 2022 using an extensive operational database of SARS-CoV-2 tests in Geneva. We used permutation to compare the total number of secondary infections occurring at the same address with that reported through manual contact tracing.

Results

Contact tracing captured on average 41% of secondary infections, varying from 23% during epidemic peaks to 60% during low epidemic activity. People living in wealthy neighbourhoods were less likely to report contacts (odds ratio (OR): 1.6). People living in apartment buildings were also less likely to report contacts than those living in a house (OR: 1.1–3.1) depending on the SARS-CoV-2 variant, the building size and the presence of shops. This under-reporting of contacts in apartment buildings decreased during periods of mandatory wearing of face masks and restrictions on private gatherings.

Conclusion

Contact tracing alone did not detect sufficient secondary infections to reduce the spread of SARS-CoV-2. Campaigns targeting specific populations, such as those in wealthy areas or apartment buildings, could enhance coverage. Additionally, measures like wearing face masks, improving ventilation and implementing restrictions on gatherings should also be considered to reduce infections resulting from interactions that may not be perceived as high risk.
Effectiveness of the adapted bivalent mRNA COVID-19 vaccines against hospitalisation in individuals aged ≥ 60 years during the Omicron XBB lineage-predominant period: VEBIS SARI VE network, Europe, February to August, 2023
Authors: Antunes Liliana , Mazagatos Clara , Martínez-Baz Iván , Gomez Verónica , Borg Maria-Louise , Petrović Goranka , Duffy Róisín , Dufrasne François E , Dürrwald Ralf , Lazar Mihaela , Jancoriene Ligita , Oroszi Beatrix , Husa Petr , Howard Jennifer , Melo Aryse , Pozo Francisco , Pérez-Gimeno Gloria , Castilla Jesús , Machado Ausenda , Džiugytė Aušra , Karabuva Svjetlana , Fitzgerald Margaret , Fierens Sébastien , Tolksdorf Kristin , Popovici Silvia-Odette , Mickienė Auksė , Túri Gergő , Součková Lenka , Nicolay Nathalie , Rose Angela MC ,   on behalf of the European Hospital Vaccine Effectiveness Group
Published: January 2024

We conducted a multicentre hospital-based test-negative case–control study to measure the effectiveness of adapted bivalent COVID-19 mRNA vaccines against PCR-confirmed SARS-CoV-2 infection during the Omicron XBB lineage-predominant period in patients aged ≥ 60 years with severe acute respiratory infection from five countries in Europe. Bivalent vaccines provided short-term additional protection compared with those vaccinated > 6 months before the campaign: from 80% (95% CI: 50 to 94) for 14–89 days post-vaccination, 15% (95% CI: −12 to 35) at 90–179 days, and lower to no effect thereafter.
FEATURES OF THE FUNCTIONING OF INNOVATIVE TEAMS IN THE PRESCHOOL EDUCATION SYSTEM
Authors:   Moscow Pedagogical State University, Molchanova Galina V. ,   Russian Medical Academy of Continuous Professional Education,   Institute of Child Development, Health and Adaptation
Published: January 2024

The issues of forming innovative teams are mainly considered in the context of improving the efficiency of business companies. Nevertheless, educational organizations also operate in the competitive market of educational services and have to integrate innovations into their activities. The specifics of the organization and functioning of innovative teams in the preschool education system are identified and described as well as the reasons of their low efficiency
SPORTS IDENTITY AS CONDITION FOR CONSERVATION OF SUSTAINABLE MOTIVATION FOR SPORTS IN CHILDREN AND ADOLESCENTS
Authors:   Lomonosov Moscow State University, Molchanova Anastasiya A.
Published: January 2024

Systematic sports activities create a special variant of the social situation of the development, include children from an early age in the community of “athletes”. During active sports, there is a change in the child’s lifestyle and quite often, a change of leading activity. Sports activities assume the early inclusion of the child in the competitive environment, as well as the dominance of achievement motivation. Young athletes devote a lot of time and energy to training. In that respect, an important role is played by the process of formation of such a personal characteristic of a child as “sports identity”, which is formed already at the primary school age. In the course of an empirical study, it was shown that the level of sports identity is directly proportional to the duration of sports activities. Children involved in active sports are satisfied with their lives, environment and current events in the same way as their age peers who are not engaged in sports activities. Along with it, a high level of sports identity contributes to maintaining a stable motivation to continue to go in for sports. Therefore, the formation of sports identity in athlete’s childhood is a necessary condition for creating motivation to be included in the community “athletes” in the long term, which, of course, also becomes a separate task for parents, coaches, sports and age psychologists.
FEATURES OF WOMEN’S SUBJECTIVE WELL-BEING IN A SITUATION OF SOCIAL TRANSITIVITY. AGE ASPECT
Authors:   Russian State University for the Humanities, Zolotareva Svetlana E.
Published: January 2024

The relevance of the study is determined by the successive global changes of the last few years in a row, characterized as a situation of social transitivity. There are more and more new challenges that require a person’s ability to adapt, which cannot but affect psychological well-being. The assumption that subjective well-being in the current situation of social transitivity depends on the initial state of a person and his age determined the direction of the study. The aim of the work is an empirical study of the age specifics of subjective well-being, resilience and life-meaning orientations, features of experience and their connections among women in the current situation of social transitivity. The study involved 426 women (N = 426) living in different cities of Russia. Data collection was carried out in the period from May 2022 to July 2023. The results obtained prove the importance of belonging to age groups of maturity for subjective well-being and the expression of such personal resources as resilience and life-meaning orientations. In addition, it was found that the structure of resilience and life-meaning orientations, as well as their relationship with the components of subjective well-being differ in different phases of maturity, namely, they decrease to extinction with some exceptions.
Implicaciones Fiscales de las Operaciones con Criptomonedas en México
Authors: Campos-Gutiérrez Diana Valeria , Moreno-Neri José de Jesús , Obregón-Angulo María del Mar
Published: January 2024

Derivado de la publicación de la Ley FinTech en 2018, surgió el debate acerca del tratamiento tributario de las operaciones con criptomonedas, que son ofrecidos por las instituciones de tecnología financiera, debido a que la regulación no es clara al respecto porque no se sabe si se trata de una moneda, un valor o un bien, por lo tanto, se desconocen los procesos fiscales. El objetivo general de la investigación es analizar las implicaciones fiscales de las operaciones con criptomonedas en México. La investigación se desarrolló mediante un enfoque cualitativo tipo documental. El estudio arrojó como resultado que las criptomonedas no son monedas de curso legal ni tampoco son valores. Considerando como conclusión que estamos ante un bien intangible, el cual deberá tributar bajo el régimen de enajenación de bienes.
Propuesta de normativa administrativa fiscal para el arrendamiento de vivienda: Caracterización y evasión de ISR
Authors: López-Villa Benia Guadalupe , López-Torres Virginia Guadalupe
Published: January 2024

La nueva forma de hacer negocios ha evolucionado rápidamente, pero las legislaciones fiscales no se encuentran preparadas para estos cambios, a consecuencia de ello se encuentra la economía informal. Con las actuales formas de hospedarse o alquilar mediante el uso de las plataformas como airbnb, donde las formalidades del servicio no están al alcance las autoridades. El régimen de arrendamiento es el régimen con más evasión en México, en la presente investigación se realiza una estimación de la evasión del alquiler de casa habitación de ISR de personas físicas en la ciudad de Ensenada, Baja California, a fin de revelar a cuánto ascienden los ingresos tributarios que la federación está dejando percibir así como proponer medidas para la disminución de la evasión.
Clima laboral: un factor que afecta al desempeño docente
Authors: Escobar-Olguín Héctor Enrique , Flores-Solís Fabiola Odette , Carreón-Ávila. Reyna Yarelly
Published: January 2024

El presente estudio tuvo como propósito verificar el ambiente laboral del Instituto, en relación a la plantilla docente. Constatar si el desempeño es el adecuado al ambiente laboral. La investigación se desarrolla en el ITS de San Pedro de las Colonias. Se utiliza una metodología cuantitativa y diagnóstica para obtener información. Se diseñaron dos Instrumentos para recopilar información. De la información obtenida se descubre que la comunicación, el respeto, la satisfacción, la equidad, entre otros, representan factores completamente relacionados con el tema del presente estudio. La muestra que estuvo a favor del análisis se conformó por 21 docentes. Los instrumentos utilizados, se validaron estadísticamente a través del Alfa de Cronbach (con un resultado de 0.838), posteriormente, se concluye que el clima laboral que envuelve a la Institución es el óptimo y de igual manera el docente tiene un buen desempeño, sin embargo, el hecho de que no existiera un clima laboral favorable no afecta su manera de trabajar.
Propuesta de mejora para una percepción favorable de los empleados sobre la situación de responsabilidad social de una empresa maquiladora
Authors: González-Larrinaga Lucio Alberto , Sánchez-López Eduardo
Published: January 2024

A partir de los resultados de una encuesta para determinar la situación de la responsabilidad social de una empresa percibida por sus empleados se definió una estrategia enfocada a promover una percepción favorable de estos. El instrumento utilizado constó de 59 reactivos divididos en cuatro secciones (empleados, medio ambiente, ética y legal) y la opción de respuesta fue en escala Likert. El instrumento fue sometido tanto a una prueba piloto como a una de fiabilidad en la que se utilizó el alfa de Cronbach. En general resultados del presente trabajo indicaron que la empresa no presenta buenas condiciones en el área de responsabilidad social destacando por sus calificaciones bajas igualdad laboral, compensación y salud mental. A partir de los resultados obtenidos se establecieron una serie priorizada de recomendaciones encaminadas a mejorar la situación de la responsabilidad social de la empresa cuya base fue el valor promedio de las respuestas obtenidas en cada reactivo.
Design of Sustainable Systems-Product-Services for the Internet of Things in design undergraduate courses
Authors:   UNISINOS, Diehl Marcia Regina , Barauna Debora ,   UNISINOS
Published: January 2024

This article aims to present a Strategic Design method for the design of sustainable systems-productservices aimed at the Internet of Things (IoT) applied in design undergraduate courses, in project disciplines. The d.e.coisas method is part of the Strategic Design approach and covers the relational discussion of topics such as emerging technologies and sustainability. To ensure that designers reflect on sustainability during design, some design tools used in the d.e.coisas method were analysed from this perspective and applied as a test in a product design course for the IoT of the undergraduate design course at a Brazilian university. With the results of this analysis, we proposed a framework, in the form of a lesson plan, that provides guidance on the development of sustainable systems-product-services projects focused on emerging technologies.
Characteristics of tickborne infections in the underexplored areas of the Trans-Baikal Territory
Authors: Lagunova E. K. , Khasnatinov M. A. , Danchinova G. A.
Published: January 2024

Background. Infections transmitted to humans by the bites of ixodid ticks remain an urgent public health problem. In this work we explored the natural foci of tickborne infections located in the valley of the Chikoy River, which is a part of the buffer zone of the Baikal natural territory.

The aim. To characterize the modern diversity and prevalence of tick-borne pathogens in the ecosystems of the valley of the Chikoy River (Trans-Baikal Territory, Russian Federation).

Materials and methods. Thirteen sampling sites were located in typical biotopes throughout the Chikoy valley. In total 48  adult Ixodes persulcatus ticks, 1  female Haemaphysalis concinna tick and 38 specimens of small mammals were studied. All samples were tested for infection with seven tick-borne pathogens using multiplex real-time PCR.

Results. No pathogens were detected in the H. concinna specimen. No R. sibirica and R. heilongjiangensis were detected both in ticks and in rodents. Among I. persulcatus, tick-borne encephalitis virus (TBEV), and the prevalence of Borrelia burgdorferi s. l. comprised 39.5 %, A. phagocytophilum – 16.7 %, B. miyamotoi – 8.3 % and Ehrlichia sp. – 2.1 %. Among infected ticks 6.2 % were co-infected with B. burgdorferi s. l. and A. phagocytophilum. Four rodent hosts of ticks and infections were identified: Myodes rufocanus (44.7  %), Apodemus peninsulae (39  %), Microtus oeconomus (13.2  %) and M.  rutilus (2.6  %). Mean prevalence of B.  burgdorferi  s.  l. in  rodents comprised 39.5 %, B. miyamotoi – 28.9 %, Ehrlichia sp. – 21.1 % and A. phagocytophilum – 18.4 %. TBEV was detected in 5.3 % of rodents.

Conclusion. At least five tick-borne pathogens circulate in the Chikoi River valley, i. e. TBEV, B. burgdorferi sensu lato, A. phagocytophilum, B. miyamotoi and Ehrlichia sp. The wide spread of I. persulcatus and abundance of competent rodent hosts of infections and ticks indicates that natural foci of tick-borne diseases are widely distributed in the Chikoi River valley.
The rs11385942 and rs657152 variants are not associated with COVID-19 severity and outcomes in patients treated with favipiravir and remdesivir
Authors: Abdullaev Sh. P. , Denisenko N. P. , Temirbulatov I. I. , Kachanova A. A. , Tuchkova S. N. , Mikhaylenko E. V. , Kryukov A. V. , Valiev T. T. , Mirzaev K. B. , Sychev D. A.
Published: January 2024

Background. There is a mounting evidence in the scientific literature that susceptibility to SARS-CoV-2 infection could vary. The severity of COVID-19 symptoms can  range from asymptomatic to severe respiratory failure, requiring prolonged artificial ventilation. The underlying causes of this range of clinical manifestations remain unclear. Identification of the risk factors that may cause this variation in clinical symptoms is important for identifying the most susceptible populations at highest risk. This should help improve prevention measures, reduce hospitalizations, and decrease the mortality rate of the disease. Previously, an association has been found between the severity of COVID-19 and the genetic markers rs11385942 G>GA and rs657152 A>C.

The aim. To assess the impact of carrying polymorphic markers rs11385942 G>GA and rs657152 A>C on the severity of COVID-19 in patients undergoing specific therapy. Materials and methods. A total of 240 patients hospitalized with a coronavirus infection were included in the study. All patients received therapy with favipiravir or remdesivir. The presence of the rs11385942 G>GA and rs657152 A>C variants was determined in all patients. The study compared the length of hospital stays, frequency of patient transfers to the intensive care unit (ICU), and frequency of clinical outcomes (recovery or death) among carriers of allelic variants of the markers under investigation.

Results. There were no significant associations between the carriage of variants rs11385942 G>GA and rs657152 A>C and the duration of patients’ hospitalization, frequency of patient transfers to the ICU, and patient outcomes.

Conclusion. The carriage of rs11385942 G>GA and rs657152 A>C variants did not affect the severity or type of clinical outcomes in patients with COVID-19.
Production of angiogenesis mediators and the structure of the vascular wall in the heart in ischemic cardiomyopathy
Authors: Chumakova S. P. , Urazova O. I. , Shipulin V. M. , Sukhodolo I. V. , Stelmashenko A. I. , Denisenko O. A. , Andreev S. L. , Demin M. S. , Churina E. G.
Published: January 2024

Background. In the pathogenesis of ischemic cardiomyopathy (ICMP), angiopoiesis remains unexplored.

The aim. To describe the vasculature of the heart and the imbalance of angiogenesis mediators in the coronary circulation in association with the number of endothelial progenitor cells (EPC) and desquamated endothelial cells (DEC) in the blood of patients with coronary heart disease (CHD), suffering and not suffering from ICMP.

Methods. Fifty-two patients with CHD (30  patients with ICMP, 22  patients without  ICMP), 15  healthy donors were examined. The content of EPC (CD14+CD34+VEGFR2+) in the blood from the cubital vein and DEC (CD45–CD146+) in the blood from the coronary sinus and the cubital vein was determined by flow cytometry. The concentrations of VEGF-A (vascular endothelial growth factor A), PDGF (platelet-derived growth factor), and SDF-1 (stromal cell-derived factor 1) in blood plasma were recorded using immunofluorescence assay; the angiopoietin-2, MMP-9 (matrix metallopeptidase 9) were recorded using enzyme immunoassay. In myocardial biopsies the specific area of vessels and the expression of αSMA (smooth muscle alpha-actin) were determined by morphometric and immunohistochemical methods.

Results. In the peripheral blood of patients with CHD, regardless of the presence of ICMP, the DEC content exceeded the physiological level, and the VEGF-A, PDGF, angiopoietin-2, and MMP-9 corresponded to the norm. In CHD patients without cardiomyopathy, there was an excess of SDF-1 and EPC in the blood from the cubital vein, and in ICMP, their physiological significance was noted. In the coronary blood flow in patients with CHD without cardiomyopathy, an increase in the concentration of PDGF was found, which was not determined in patients with ICMP, who had an increased content of DEC, angiopoietin-2 and MMP-9. The specific area of the vessels in the patients of the two groups was comparable; the expression of αSMA in ICMP was 6.2 times lower than in patients with CHD without cardiomyopathy.

Conclusion. The development of ICMP is accompanied by impaired maturation of vessels in the myocardium, associated with the absence of a compensatory reaction of activation of cellular and humoral factors of angiogenesis.
Interdisciplinary research organization for pupils in grades 8-11 during extracurricular classes in the humanities, mathematics and natural sciences
Authors: Makotrova Galina Vasilievna , Penkov Sergey Viktorovich , Irkhin Vladimir Nikolaevich , Kormakova Valentina Nikolaevna
Published: January 2024

The research aims to reveal the peculiarities of interdisciplinary research organization for pupils in grades 8-11 by a teacher in extracurricular classes in the humanities, mathematics and natural sciences. The paper describes the implementation of an interdisciplinary approach in Russian and foreign school education, highlights the problems of its use in the activities of Russian teachers. The authors present the results of a modeling experiment showing a low level of high school students’ readiness to establish interdisciplinary connections during the study of popular scientific texts in the humanities, mathematics and natural sciences. The scientific novelty of the work lies in determining the pedagogical conditions for organizing interdisciplinary research for pupils in grades 8-11 during extracurricular classes in the humanities, mathematics and natural sciences. As a result of organizing interdisciplinary team research for schoolchildren in the context of the interrelation of curricular and extracurricular cognitive activities, the development of pupils’ motivation to master modern scientific knowledge, creative activity, technological readiness for search activities, scientific style of thinking was noted; the deepening of the content of the academic disciplines (Chemistry, History) was achieved, maintaining its consistency and systematicity.
Replenishment of the VIR perennial forage crops collection with samples from a collecting mission in Tambov and Ryazan provinces in 2018
Authors: Malysheva N. Yu. , Gridnev G. A. , Belskaya G. V. , Gubanova E. A.
Published: January 2024

The purpose of the collecting mission was to replenish the collection of perennial forage crops with crop wild relatives (CWR) of interest for breeding purposes, as well as for the subsequent preservation of forage CWR diversity in natural populations. The mission was tasked to conduct a survey of the territory along the middle and lower Tsna river and collect seeds of wild perennial and annual forages. Coordinates of collecting sites were recorded and sites mapped together with the collecting mission route. Two districts of the Tambov and two districts of Ryazan provinces were explored. As a result, 93 seed samples were collected. Out of these, 47 samples were perennial forage grasses, 39 perennial and annual forage legumes, and 7 belonged to other families. The main part of legumes was represented by Medicago species (11 samples of Medicago falcata L., M. varia Mart., M. lupulina L.) and clover (11 samples of Trifolium hybridum L., T. incarnatum L., T. medium L., T. pratensis L., T. repens L.); among the grasses there were Bromopsis inermis (Leyss.) Holub, Poa angustifolia L., Dactylis glomerata L., and Phleum pratense L.
Upaya Kantor Urusan Agama dalam Mencegah Perkawinan Dini di Kecamatan Lolak, Bolaang Mongondow
Authors: Amiri Kartika Septiani , Paputungan Rahmat
Published: January 2024

This research focuses on the role of the Office of Religious Affairs/Kantor Urusan Agama (KUA) in reducing early marriage rates and the variables influencing such events in the Lolak Subdistrict, Bolaang Mongondow Regency, North Sulawesi. A qualitative descriptive method with a phenomenological approach is employed to understand participants' experiences regarding early marriage comprehensively. The research results indicate that the KUA plays a crucial role in lowering the incidence of early marriages in the Lolak Subdistrict. They refuse to approve marriages that violate the age limits set by Law Number 16 of 2019. In addition to withholding approval, the KUA also conducts educational programs to provide the community an understanding of these regulations. Islamic guidance is delivered directly in classroom settings to prevent early marriages. This research seeks to uncover the role of the KUA in addressing early marriages and the influencing variables in the Lolak Subdistrict. With an emphasis on education and the refusal to approve early marriages, the KUA is a crucial agent in combating early marriages in the region. Keywords: Office of Religious Affairs; Marriage, Early Age. ABSTRAKPenelitian ini berfokus pada peran Kantor Urusan Agama (KUA) dalam mengurangi angka pernikahan dini serta variabel yang mempengaruhi peristiwa tersebut di Kecamatan Lolak, Kabupaten Bolaang Mongondow, Sulawesi Utara. Metode deskriptif kualitatif dengan pendekatan fenomenologi digunakan untuk mendapatkan gambaran komprehensif terhadap pengalaman partisipan penelitian seputar pernikahan dini. Hasil penelitian menunjukkan bahwa KUA memainkan peran yang penting dalam menurunkan angka pernikahan dini di Kelurahan Lolak. Mereka menolak memberikan persetujuan terhadap pernikahan yang melanggar batasan usia yang ditetapkan dalam Undang-Undang Nomor 16 Tahun 2019. Selain menolak persetujuan, KUA juga menggelar program edukasi untuk memberikan pemahaman kepada masyarakat tentang peraturan tersebut. Bimbingan Islam disampaikan secara langsung dalam setting kelas untuk mencegah terjadinya pernikahan dini. Penelitian ini berusaha  mengungkap peran KUA dalam menangani pernikahan dini serta variabel-variabel yang mempengaruhinya di Kecamatan Lolak. Dengan penekanan pada edukasi dan penolakan persetujuan pernikahan dini yang ditentukan, KUA bertindak sebagai agen penting dalam memerangi pernikahan dini di wilayah tersebut.
Investigation of the properties of polyamide-6 prepolymer granulate
Authors:   Ivanovo State University of Chemical Technology, Barannikov M.V. , Polyakov V.S. ,   Ivanovo State University of Chemical Technology, Bazarov Yu.M. ,   Ivanovo State University of Chemical Technology, Osipova G.V. ,   Ivanovo State University of Chemical Technology, Krivenko K.A. ,   Ivanovo State University of Chemical Technology
Published: January 2024

A technological process for low-temperature hydrolytic polymerization of caprolactam in a melt is being developed, which includes two stages: 1) prepolymer synthesis; 2) continuous combined drying–demonomerization of the granulate. The first stage of the process was carried out at a temperature of 210-220°C. The synthesized prepolymer samples were investigated for the content of low molecular weight compounds and relative viscosity.
Potential Alternative Receptors for SARS-CoV-2-Induced Kidney Damage: TLR-4, KIM-1/TIM-1, and CD147
Authors: Habeichi Nada J. , Amin Ghadir , Lakkis Bachir , Kataya Rayane , Mericskay Mathias , Booz George W. , Zouein Fouad A.
Published: January 2024

Kidney damage in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can occur even in patients with no underlying kidney disease. Signs of kidney problems can progress to a state that demands dialysis and hampering recovery. Although not without controversy, emerging evidence implicates direct infectivity of SARS-CoV-2 in the kidney. At the early stage of the pandemic, consideration was mainly on the well-recognized angiotensin-converting enzyme 2 (ACE2) receptor as being the site for viral interaction and subsequent cellular internalization. Despite the abundance of ACE2 receptors in the kidneys, researchers have expanded beyond ACE2 and identified novel viral entry pathways that could be advantageously explored as therapeutic targets. This review presents the potential involvement of toll-like receptor 4 (TLR-4), kidney injury molecule-1/T cell immunoglobulin mucin domain 1 (KIM-1/TIM-1), and cluster of differentiation 147 (CD147) in SARS-CoV-2-associated renal damage. In this context, we address the unresolved issues surrounding SARS-CoV-2 renal infectivity.
Quantitative Proteomics Analysis Reveals the Potential Role of lncRNA FTX in Endothelial Cells
Authors: Zhao Qi , Lan Yadi , Shi Xiuju , Sun Xiangfei
Published: January 2024

Objective: This study investigated the role of long non-coding RNAs (lncRNAs) FTX in vascular endothelial cells (ECs). Methods: Transfection of FTX/Sh-FTX with lentivirus was used to construct gain and loss of function cell models in human umbilical vein endothelial cells (HUVECs). Liquid chromatography-mass spectrometry was used for quantitative proteomics analysis of differentially expressed proteins (DEPs). Gene Ontology, Kyoto Encyclopedia of Genes and Genomes, and protein interaction analysis were further conducted to investigate the key molecules and pathways that respond to lncRNA-FTX. Results: In the proteomics analysis, 3308 quantifiable proteins were identified, 64 proteins were upregulated and 103 were downregulated when lncRNA FTX was overexpressed. Additionally, 100 proteins were upregulated and 147 were downregulated when lncRNA FTX was knocked down. Functional clustering analysis of DEPs demonstrated that lncRNA FTX was involved in multiple biological processes. Among them, the expression of complement 3 (C3), cartilage oligomeric matrix protein (COMP), faciogenital dysplasia 6 (FGD6), and tissue inhibitor of metalloproteinase 1 (TIMP1) was significantly upregulated when lncRNA FTX was knocked down, and significantly downregulated when lncRNA FTX was overexpressed. They are associated with inflammation, collagen deposition, angiogenesis, and regulation of liver stem cell differentiation, which may be associated with the occurrence and development of liver fibrosis. Conclusions: The study demonstrated that lncRNA FTX might play a potential role in ECs and contribute to the development of liver fibrosis. Thus, FTX may be a promising target for the prevention or reversal of liver fibrosis.
O-glycoprofiling of Serum Apolipoprotein C-III in Colorectal Cancer
Authors: Kianičková Kristína , Pakanová Zuzana , Květoň Filip , Holazová Alena , Kundalia Paras H. , Baráth Peter , Miljuš Goran , Nedić Olgica , Katrlík Jaroslav
Published: January 2024

Background: Aberrant glycosylation is a hallmark of cancer and thereby has an excellent potential for the discovery of novel biomarkers. Impairments in the glycan composition of lipoproteins impact their functional properties and can be associated with various diseases, including cancer. This research is still in its infancy; however, it can lead to the development of new diagnostic and disease stratification approaches as well as therapeutic strategies. Therefore, we aimed to evaluate anomalies in O-glycosylation of apolipoprotein C-III (apoC-III) in colorectal carcinoma (CRC) patients’ sera, in comparison with sera from healthy individuals, and assess the disparities of O-glycoforms on apoC-III in CRC. Methods: The choice of patients (n = 42) was based on the same tumor type (adenocarcinoma) and tumor size (T3), without or with inconsiderable lymph node infiltration. Patients with comorbidities were excluded from the study. The control healthy individuals (n = 40) were age- and sex-matched with patients. We used an approach based on the MALDI-TOF MS in linear positive ion mode, allowing simple analysis of O-glycosylation on intact apoC-III molecules in the serum samples directly, without the need for specific protein isolation. This approach enables relatively simple and high-throughput analysis. Results: In CRC patients’ sera samples, we observed significantly elevated apoC-III sialylation. Fully sialylated (disialylated) O-glycans had 1.26 times higher relative abundance in CRC samples compared to controls with a p-value of Mann–Whitney U test of 0.0021. Conclusions: We found altered O-glycosylation of apoC-III in the serum of CRC patients. However, it can be non-specific as it may be associated with another process such as ongoing inflammation. Therefore, to establish it as a potential novel non-invasive biomarker for CRC in suspected patients, further studies interrogating the changes in apoC-III O-glycosylation and the robustness of this biomarker need to be performed and evaluated.
Tissue Iron in Friedreich Ataxia
Authors: Koeppen Arnulf H
Published: January 2024

Heart, dentate nucleus, and dorsal root ganglia (DRG) are targets of tissue damage in Friedreich ataxia (FA). This report summarizes the histology and histopathology of iron in the main tissues affected by FA. None of the affected anatomical sites reveals an elevation of total iron levels. In the myocardium, a small percentage of fibers shows iron-reactive granular inclusions. The accumulation of larger iron aggregates and fiber invasion cause necrosis and damage to the contractile apparatus. In the dentate nucleus, the principal FA-caused tissue injury is neuronal atrophy and grumose reaction. X-ray fluorescence mapping of iron in the dentate nucleus in FA shows retention of the metal in the center of the collapsed structure. Immunohistochemistry of ferritin, a surrogate marker of tissue iron, confirms strong expression in oligodendrocytes of the efferent white matter of the dentate nucleus and abundance of ferritin-positive microglia in the atrophic gray matter. Iron dysmetabolism in DRG is complex and consists of prominent expression of ferritin in hyperplastic satellite cells and residual nodules, also a loss of the iron export protein ferroportin from the cytoplasm of the remaining DRG nerve cells.
Insufficient Ablation is Associated with Atrial Fibrillation Recurrence after Combining Ablation and Left Atrial Appendage Closure
Authors: Ding Xueyan , Zhao Yao , Dong Shaohua , Huang Xinmiao , Qin Aihong , Cao Jiang , Guo Zhifu , Huang Songqun
Published: January 2024

Background: The combination of left atrial appendage closure (LAAC) and catheter ablation (CA) in a single procedure is a safe and effective form of treatment for atrial fibrillation (AF). However, several findings have argued that LAAC might increase the risk of AF recurring. Therefore, this study investigated the impact of insufficient ablation on AF recurrence after the hybrid procedures of CA and LAAC. Methods: We reviewed 107 consecutive patients with AF who received the CA and LAAC hybrid procedures (combined group). In the case–control study, another 107 patients who underwent only CA (ablation group) were successfully matched using propensity score matching. After correcting the insufficient ablation, 107 consecutive patients were enrolled prospectively. During the follow-up period, postprocedural 24-hour monitor recordings and a portable electrocardiogram (ECG) monitoring device were used to detect AF recurrence. Transesophageal echocardiography was used to evaluate LAAC. Results: The combined group showed an increase in the risk of AF recurrence after 539.2 ± 304.4 days of follow-up (29.9% vs. 15.9%, p < 0.05). Interestingly, the duration of the procedure was not significantly prolonged when LAAC was added after CA in the combined group, while there was a higher number of ablating attempts, duration of ablation, and additional ablation in the ablation group for both radiofrequency and cryoballoon ablation. After correcting for the insufficient ablation, the corrected group showed a significant decrease in AF recurrence after 420.4 ± 204.8 days of follow-up. Conclusions: Insufficient ablation is common when combining CA and LAAC and may lead to the recurrence of atrial fibrillation. It should be corrected intentionally by sufficient ablation of the pulmonary vein antrum and additional ablation. Clinical Trial Registration: The prospective study is a sub-study of our CAGEDAF study that has already been registered (ChiCTR2000039746).
Progress in the Use of Echocardiography in Patients with Tumors
Authors: Feng Tiantian , Guo Zhaoxia , Su Hongling , Zhang Fu , Zhu Hai , Wang Aqian , Jiang Kaiyu , Li Bo
Published: January 2024

Advances in cancer treatment have increased patient survival rates, shifting clinical focus towards minimizing treatment-related morbidity, including cardiovascular issues. Since echocardiography allows for a comprehensive non-invasive assessment at all cancer stages, it is well suited to monitor cardiovascular disease secondary to oncology treatment. This has earned it significant attention in the study of cardiac tumors and treatment-induced cardiac alterations. Ultrasound methods—ranging from transthoracic and transesophageal echocardiography to ultrasound diagnostic techniques including myocardial strain imaging, myocardial work indices, three-dimensional cardiac imaging—offer a holistic view of both the tumor and its treatment impact cardiac function. Stress echocardiography, myocardial contrast echocardiography, and myocardial acoustic angiography further augment this capability. Together, these echocardiographic techniques provide clinicians with early detection opportunities for cardiac damage, enabling timely interventions. As such, echocardiography continues to be instrumental in monitoring and managing the cardiovascular health of oncology patients, complementing efforts to optimize their overall treatment and survival outcomes.
Law enforcement authorities Osh region of the Kyrgyz SSR during the Great Patriotic War
Authors: Akmatova Amanai
Published: January 2024

During the Great Patriotic War, the law enforcement agencies of Soviet Kyrgyzstan performed a number of tasks related to maintaining public order in the country and the security of all citizens; special attention was paid to suppressing crimes to protect socialist legality and control the civilian population. Law enforcement agencies patrolled the streets of cities to carry out passport registration among visitors, fought against child homelessness and neglect. The article uses for the first time unpublished archival documents of party organs; minutes of the meeting of the bureau of the Osh regional party committee and reports of the heads of state and party authorities.
Assessing Criterion and Longitudinal Validity of Submaximal Heart Rate Indices as Measures of Cardiorespiratory Fitness: A Preliminary Study in Football
Authors: Shushan Tzlil , Lovell Ric , McLaren Shaun J. , Buchheit Martin , Dello Iacono Antonio , Soley Adriano Arguedas , Norris Dean
Published: January 2024

Objectives: To evaluate the criterion and longitudinal validity of field- and laboratory-derived heart rate (HR) indices of resting and submaximal fitness tests (SMFTs) as measures of cardiorespiratory fitness. Design: Observational, repeated measures. Methods: Twenty-nine semi-professional footballers participated. Laboratory assessments took place at the start and end of a preseason training period, whereby resting, SMFT HR-derived indices, and criterion measures of cardiorespiratory fitness (running economy [RE], maximal oxygen uptake [V ̇O2max] and aerobic speed [MAS]) were collected. Throughout this training period, two field-based SMFT protocols, prescribed at different intensities, were administered weekly. Individual slopes were calculated from the analysis of within-athlete change scores. Associations between laboratory and field measures were assessed via Pearson’s correlation coefficient (r) and linear regression models.Results: Relationships between SMFT HR-derived indices from laboratory and field were very-large for exercise HR (r=0.74 to 0.87) and moderate to very-large for HR recovery (0.43 to 0.76). Moderate to very-large inverse relationships were observed between exercise HR and HR recovery with V ̇O2max and MAS (–0.41 to –0.78), whereas resting HR showed no substantial relationships. Changes in exercise HR showed large and very-large inverse correlations with preseason changes in V ̇O2max (–0.54 to –0.60) and MAS (–0.64 to –0.83). Relationships between changes in HR recovery and maximal cardiorespiratory criterion measures were moderate to large (–0.32 to –0.63). Conclusion: SMFT exercise HR is a valid proxy measure of cardiorespiratory fitness irrespective of test setting, whereas the validity of HRR remains elusive and appears to vary between exercise intensities.
Lexical surprisal shapes the time course of syntactic structure building
Authors: Slaats Sophie , meyer antje , Martin Andrea E.
Published: January 2024

When we understand language, we recognize words and combine them into sentences. In this paper, we explore the hypothesis that listeners use probabilistic information about words to build syntactic structure. Recent work has shown that lexical probability and syntactic structure both modulate the delta-band (0-4 Hz) neural signal. Here, we investigated whether the neural encoding of syntactic structure changes as a function of the distributional properties of a word. To this end, we analyzed MEG data of 24 native speakers of Dutch who listened to three fairytales with a total duration of 49 minutes. Using temporal response functions and a cumulative model-comparison approach, we evaluated the contributions of syntactic and distributional features to the variance in the delta-band neural signal. This revealed that lexical surprisal values (a distributional feature), as well as bottom-up node counts (a syntactic feature) positively contributed to the model of the delta-band neural signal. Subsequently, we compared responses to the syntactic feature between words with high- and low surprisal values. This revealed a delay in the response to the syntactic feature as a consequence of the surprisal value of the word: high surprisal values were associated with a delayed response to the syntactic feature by 150 to 190 milliseconds. The delay was not affected by word duration, and did not have a lexical origin. These findings suggest that the brain uses probabilistic information to infer syntactic structure, and highlight an importance for the role of time in this process.