bluuebunny/crossref_metadata_2025 huggingface dataset:
Key Flow Processes on Wards
Authors: Karvonen Sauli , Holma Tuomas , Korpelainen Juha , Leivonen Kirsi , Michelsson Kristiina , Rantala Minna-Riikka , Porkkala Timo , Lukkarila Pirjo
Published: November 2022

Objective:

The aim of the study is to test a new nurse movement route analysis (NMRA) method for measuring nurses’ traffic volume between rooms on wards.

Background:

The World Health Organization calls for urgent investment in nurses. On the other hand, the challenges in the availability, direct care activity, and staffing of registered nurses make increasing the quality of care by process improvement a central objective for nursing.

Method:

The method is based on cellular operations with from/to matrix that describes nurse movements between rooms on a ward. The NMRA can be implemented by traditional manual observation or with a novel internet-of-things solution named SKAnalysis.

Results:

The greatest nurse flows led to patient rooms, nurses’ stations, and medicine rooms. The manual NMRA recorded a total of 3,040 room visits by nurses; visits to patient rooms accounted for 33% of all room visits, while visits to nurses’ stations accounted for 28%, and visits to the medicine room for 10%. The internet-of-things NMRA recorded a total of 25,841 room visits by nurses; patient room visits accounted for about 43% of all room visits, while nurses’ station visits accounted for 26% and medicine room visits for about 8%. Based on the results, researchers present the development examples and priorities for nursing.

Conclusions:

NMRA works and is a new universal method for analyzing nurses’ traffic which is a basic premise for improving working methods and productivity on the wards. Internet-of-things solution makes the implementation of NMRA six times more efficient than by the manual NMRA.
Clinical evaluation of the efficacy of a new bone cement-injectable cannulated pedicle screw in the treatment of spondylolysis-type lumbar spondylolisthesis with osteoporosis: a retrospective study
Authors: Song Lei , Xiao Jun , Zhou Rui , Li Cong-can , Zheng Ting-ting , Dai Fei
Published: November 2022

Purpose

To investigate the clinical efficacy and safety of a bone cement-injectable cannulated pedicle screw (CICPS) in the treatment of spondylolysis-type lumbar spondylolisthesis with osteoporosis.

Methods

A retrospective study was conducted on 37 patients (Dual-energy X-ray bone density detection showed different degrees of osteoporosis) with spondylolysis-type lumbar spondylolisthesis who underwent lumbar spondylolisthesis reduction and fusion using a new type of injectable bone cement screw from May 2011 to March 2015. Postoperative clinical efficacy was evaluated by the Visual Analogue Scale (VAS) scores and the Oswestry Disability Index (ODI). Imaging indexes were used to evaluate the stability of internal fixation of the devices 1, 3, 6, and 12 months after surgery and annually thereafter. The safety of the CICPS was assessed by the prevalence of intraoperative and postoperative complications.

Results

A total of 124 CICPS were implanted intraoperatively. Bone cement leakage occurred in 3 screws (2.42%), and no clinical discomfort was found in any patients. All 37 patients were followed up with an average follow-up time of 26.6 ± 13.4 months (12–58 months). In the evaluation of the clinical effects of the operation, the average postoperative VAS score of the patients decreased from 4.30 ± 1.58 before surgery to 0.30 ± 0.70 after surgery (P < 0.001), and the ODI decreased from 47.27% ± 16.97% before surgery to 3.36% ± 5.70% after surgery (P < 0.001). No screw was loose, broken or pulled out.

Conclusion

CICPS is safe and effective in the treatment of spondylolysis-type lumbar spondylolisthesis complicated by osteoporosis.
A new surgical technique for short bowel syndrome
Authors: Saeki Isamu , Kurihara Sho , Kojima Masato , Ohge Hiroki , Takahashi Shinya , Hiyama Eiso
Published: November 2022

Objective

Short bowel syndrome (SBS) is a severe intestinal disease that causes malabsorption. Long-term parental nutrition therapy induces infection and liver failure. For the surgical management of intestinal rehabilitation, the intestinal loop lengthening method and serial transverse enteroplasty (STEP) method have been reported, although their effects have proven limited. We herein report a new surgical technique, Saeki–Spiral–Shark (3S) method for SBS using biomimetics of shark intestine.

Methods

In the 3S method, a spiral valve is formed inside the intestine by external sutures. Using a 25 cm length intestinal organ model, we performed both the 3S method and STEP procedure. We then compared the length and fluid passage times of the subsequently formed intestine.

Results

After the 3S method was performed, the length of the intestinal model changed to 22 cm, and after the STEP procedure, that was elongated to 30 cm. Although the water passage times did not change markedly, the semi-digestive nutritional supplement passage time slowed down in the model with the 3S method. There was slight leakage in the STEP procedure model.

Conclusions

The 3S method is a unique method of treating SBS based on biomimetics. This procedure does not require an incision of the intestine, which thereby enabling clean and less-invasive surgery. We plan to conduct animal experiments in the future.
Lateral approach is a more aesthetical option for radical resection of BSCC: assessment of its surgical, oncological, functional, and aesthetic outcomes
Authors: Wan Wen-Dong , Lu Can , yuan Yong-Xiang , Hu Jia-Ju , Liang Jie , He Cai-Yun , Huang Yu-Qi , Su Tong , Guo Feng , Jiang Can-Hua , Li Ning
Published: November 2022

Background

The purpose of this study was to introduce a modified lateral approach for combined radical resection of buccal squamous cell carcinoma (BSCC) and evaluate its surgical, oncological, functional, and aesthetic outcomes in comparison with the conventional lower-lip splitting approach.

Methods

This single-center study retrospectively reviewed 80 patients with BSCC, of which 37 underwent the lateral approach and 43 underwent the conventional approach. Surgical, functional, oncological, and aesthetic evaluations, as well as follow-ups, were recorded and compared.

Results

Compared to the conventional approach group, the lateral approach group had a longer surgical time (P = 0.000), but there was no significant difference in other surgical and oncological parameters. Moreover, the scar in the head and neck had a significantly discreet appearance in the lateral approach group, whose satisfaction was better than those in the conventional approach group (P = 0.000). Other oral function parameters, postoperative mouth-opening, and 3-year survival rate were not significantly different between the two groups.

Conclusion

The lateral approach could provide superior aesthetic results while maintaining equal surgical, functional, and oncological outcomes compared to the conventional approach for radical resection of BSCC.
At the junctures of healthcare: a qualitative study of primary and specialist service use by Polish migrants in England
Authors: Troccoli Giuseppe , Moreh Chris , McGhee Derek , Vlachantoni Athina
Published: November 2022

Background:

Polish people are the biggest migrant group in the UK and the scholarship shows that they are attentive to their healthcare needs and seek to fulfil them by using various services both within and outside the British public healthcare system. This article explores the role of junctures within healthcare systems in the connections migrants realize between healthcare systems and sectors. The article argues that in a transnational context, migrants enact these junctures by joining different levels of care within the same sector, between sectors and across national borders. In particular, the article explores how Polish migrants’ healthcare seeking practices within and beyond national borders are enacted given the features, availability and relationship between primary and specialist care for how they are articulated between private and public sectors.

Methods:

This article is based on the second phase of a mixed-methods study on how Polish people in the UK manage their health transnationally. The participants were purposefully sampled from survey respondents (first phase) who identified as having a long-term health condition or caring in a non-professional capacity for someone who is chronically ill. Thirty-two semi-structured audio-call interviews were conducted with Polish migrants living in England between June and August 2020. Transcripts were analysed by applying thematic coding.

Results:

Key findings include a mix of dissatisfaction and satisfaction with primary care and general satisfaction with specialist care. Coping strategies consisting in reaching specialist private healthcare provided a way to access specialist care at all or additionally, or to partially complement primary care. When Polish private specialists are preferred, this is due to participants’ availability of time and financial resources, and to the specialists’ capacity to fulfil needs unmet within the public healthcare sector in the UK.

Conclusion

Polish migrants join with their practices systems which are not integrated, and their access is limited by the constraints implied in accessing paid services in Poland. This shapes transnational healthcare practices as relating mostly to routine and ad-hoc access to healthcare. These practices impact not only the wellbeing of migrants and the development of the private market but also the public health provision of services.
Inferior subluxation of humeral head after osteosynthesis for greater tuberosity fracture
Authors: Furuhata Ryogo , Tanji Atsushi , Oki Satoshi , Kamata Yusaku
Published: November 2022

Background

Inferior subluxation of the humeral head is frequently observed immediately after surgery for proximal humerus fractures; however, the incidence and risk factors of inferior subluxation after osteosynthesis for isolated greater tuberosity fractures remain unsolved. Additionally, the postoperative course of inferior subluxation has not been elucidated. The purpose of the present study is to identify the predictors for the occurrence of postoperative inferior subluxation by multivariate analysis and investigate the postoperative shift of inferior subluxation and its effect on surgical outcomes.

Methods

We retrospectively identified 68 patients who underwent surgery for isolated greater tuberosity fractures. The dependent variable was the inferior subluxation at 1 week postoperatively. The explanatory variables were age, sex, affected side of the shoulder, body mass index, history of smoking, local osteoporosis, time period to surgery, axillary nerve injury, inferior subluxation before surgery, fracture dislocation, surgical approach, surgical method, operative time, amount of blood loss, and postoperative drainage. Baseline variables that were statistically significant in the univariate analyses were included in the logistic regression analysis. The patients were further categorized into two groups according to the presence of inferior shoulder subluxation exhibited 1 week postoperatively: patients with inferior subluxation (+ IS group) and patients without inferior subluxation (− IS group). We compared the incidence of postoperative complications between the two groups.

Results

Of 68 patients, 17 (25.0%) had inferior shoulder subluxation observed 1 week postoperatively. Multivariate analysis showed that long operative time was a risk factor for postoperative subluxation (odds ratio = 1.03; P = 0.030). In all cases, inferior subluxation disappeared within 3 months of surgery. No significant difference in complication rate was observed between the + IS and − IS groups.

Conclusions

The present study provides novel information regarding postoperative inferior subluxation of fractures of the greater tuberosity. Inferior subluxation occurred in 25% of patients immediately after surgery. Long operative time contributes to the onset of postoperative inferior subluxation; however, this was temporary in all cases and had no significant effect on the surgical outcomes.

Level of Evidence: Level III.
Prenatal diagnosis and genetic counseling of an inherited Xq24q25 deletion associated with normal phenotype
Authors: Zhou Yaqing , Zhang Mingxi , Zhu Yanmin , Zhao Qi
Published: November 2022

Background

Copy number variants (CNVs) are an important source of normal and pathogenic genome variations. CNVs identified in prenatal cases need careful considerations and correct interpretation if those are harmless or harmful variants from the norm.

Case presentation

A 28-year-old, gravida 1, para 0, woman underwent amniocentesis at 17 weeks of gestation because the noninvasive prenatal testing (NIPT) results revealed a 9.8 Mb deletion from Xq24 to Xq25. GTG-banding karyotype analysis was performed on cultured amniocytes. Chromosomal microarray analysis (CMA) on uncultured amniocytes was performed.

Results

Chromosomal GTG-banding of the cultured amniocytes revealed a karyotype of 46,XX. CMA detected a 9.5-Mb chromosomal deletion in the region of Xq24q25 (arr[GRCh37] Xq24q25(118,975,436_128,444,692) × 1).

Conclusion

The present report highlights that an integration of prenatal ultrasound, NIPT, karyotype analysis, CMA and genetic counseling is helpful for the prenatal diagnosis of chromosomal deletions/duplications.
Blood-based lipidomic signature of severe obstructive sleep apnoea in Alzheimer’s disease
Authors: Dakterzada Farida , Benítez Iván D. , Targa Adriano , Carnes Anna , Pujol Montse , Jové Mariona , Mínguez Olga , Vaca Rafi , Sánchez-de-la-Torre Manuel , Barbé Ferran , Pamplona Reinald , Piñol-Ripoll Gerard
Published: November 2022

Background

Obstructive sleep apnoea (OSA) is the most frequent form of sleep-disordered breathing in patients with Alzheimer’s disease (AD). Available evidence demonstrates that both conditions are independently associated with alterations in lipid metabolism. However, it is unknown whether the expression of lipids is different between AD patients with and without severe OSA. In this context, we examined the plasma lipidome of patients with suspected OSA, aiming to identify potential diagnostic biomarkers and to provide insights into the pathophysiological mechanisms underlying the disease.

Methods

The study included 103 consecutive patients from the memory unit of our institution with a diagnosis of AD. The individuals were subjected to overnight polysomnography (PSG) to diagnose severe OSA (apnoea-hypopnea index ≥30/h), and blood was collected the following morning. Untargeted plasma lipidomic profiling was performed using liquid chromatography coupled with mass spectrometry.

Results

We identified a subset of 44 lipids (mainly phospholipids and glycerolipids) that were expressed differently between patients with AD and severe and nonsevere OSA. Among the lipids in this profile, 30 were significantly correlated with specific PSG measures of OSA severity related to sleep fragmentation and hypoxemia. Machine learning analyses revealed a 4-lipid signature (phosphatidylcholine PC(35:4), cis-8,11,14,17-eicosatetraenoic acid and two oxidized triglycerides (OxTG(58:5) and OxTG(62:12)) that provided an accuracy (95% CI) of 0.78 (0.69–0.86) in the detection of OSA. These same lipids improved the predictive power of the STOP-Bang questionnaire in terms of the area under the curve (AUC) from 0.61 (0.50–0.74) to 0.80 (0.70–0.90).

Conclusion

Our results show a plasma lipidomic fingerprint that allows the identification of patients with AD and severe OSA, allowing the personalized management of these individuals. The findings suggest that oxidative stress and inflammation are potential prominent mechanisms underlying the association between OSA and AD.
Vacuolin-1 enhances RA-induced differentiation of human myeloblastic leukemia cells: evidence for involvement of a CD11b/FAK/LYN/SLP-76 axis subject to endosomal regulation that drives late differentiation steps
Authors: Zhu Kaiyuan , Kazim Noor , Yue Jianbo , Yen Andrew
Published: November 2022

Background

Retinoic acid(RA), an embryonic morphogen, regulates cell differentiation. Endocytosis regulates receptor signaling that governs such RA-directed cellular processes. Vacuolin-1 is a small molecule that disrupts endocytosis, motivating interest in its effect on RA-induced differentiation/arrest. In HL-60 myeloblastic-leukemia cells, RA causes differentiation evidenced by a progression of cell-surface and functional markers, CD38, CD11b, and finally reactive oxygen species(ROS) production and G1/0 cell cycle arrest in mature cells.

Results

We found that Vacuolin-1 enhanced RA-induced CD11b, ROS and G1/0 arrest, albeit not CD38. Enhanced CD11b expression was associated with enhanced activation of Focal Adhesion Kinase(FAK). Adding vacuolin-1 enhanced RA-induced tyrosine phosphorylation of FAK, Src Family Kinases(SFKs), and the adaptor protein, SLP-76, expression of which is known to drive RA-induced differentiation. Depleting CD11b cripples late stages of progressive myeloid differentiation, namely G1/0 arrest and inducible ROS production, but not expression of CD38. Loss of NUMB, a protein that supports early endosome maturation, affected RA-induced ROS and G1/0 arrest, but not CD38 expression.

Conclusion

Hence there appears to be a novel CD11b/FAK/LYN/SLP-76 axis subject to endosome regulation which contributes to later stages of RA-induced differentiation. The effects of vacuolin-1 thus suggest a model where RA-induced differentiation consists of progressive stages driven by expression of sequentially-induced receptors.
Cross-site collaboration on infection prevention and control research—room for improvement? A 7-year comparative study in five European countries
Authors: Eichel Vanessa M. , Brühwasser Christina , Castro-Sánchez Enrique , Birgand Gabriel , Bathoorn Erik , Salm Florian , Mutters Nico T.
Published: November 2022

Background

The spread of SARS-CoV-2, multidrug-resistant organisms and other healthcare-associated pathogens represents supra-regional challenges for infection prevention and control (IPC) specialists in every European country. To tackle these problems, cross-site research collaboration of IPC specialists is very important. This study assesses the extent and quality of national research collaborations of IPC departments of university hospitals located in Austria, England, France, Germany, and the Netherlands, identifies network gaps, and provides potential solutions.

Methods

Joint publications of IPC heads of all university hospitals of the included countries between 1st of June 2013 until 31st of May 2020 were collected by Pubmed/Medline search. Further, two factors, the journal impact factor and the type/position of authorship, were used to calculate the Scientific Collaboration Impact (SCI) for all included sites; nationwide network analysis was performed.

Results

In five European countries, 95 sites and 125 responsible leaders for IPC who had been in charge during the study period were identified. Some countries such as Austria have only limited national research cooperations, while the Netherlands has established a gapless network. Most effective collaborating university site of each country were Lille with an SCI of 1146, Rotterdam (408), Berlin (268), Sussex (204), and Vienna/Innsbruck (18).

Discussion

The present study indicates major differences and room for improvement in IPC research collaborations within each country and underlines the potential and importance of collaborating in IPC.
“In-between orthorexia” profile: the co-occurrence of pathological and healthy orthorexia among male and female non-clinical adolescents
Authors: Yakın Ecem , Obeid Sahar , Fekih-Romdhane Feten , Soufia Michel , Sawma Toni , Samaha Serena , Mhanna Mariam , Azzi Reine , Mina Anthony , Hallit Souheil
Published: November 2022

Background

The profile of adolescents with orthorexic eating behaviors remains to be explored. This study is the first to explore the typology of Lebanese adolescents from a large non-clinical sample based on orthorexia nervosa (ON) and healthy orthorexia (HO).

Method

A total of 555 adolescents (aged between 15 and 18 years) completed a set of questionnaires assessing orthorexic behaviors, self-esteem, stress, depressive and anxiety symptoms. Cluster analysis based on ON and HO scores was used to identify the typology of the sample. More precisely, this analysis was used to reveal and distinguish between naturally occurring subgroups of individuals with different orthorexic eating profiles, within the studied sample. Further, a series of one-way ANOVA was used to compare observed clusters based on their scores on used questionnaires. This analysis was used to capture the behavioral and psychological differences between previously yielded subgroups of individuals.

Results

Cluster analysis based on ON and HO scores yielded 3 distinct groups: “Low orthorexia”, “Moderate in-between orthorexia” and “High in-between orthorexia”. While the first group represented individuals with no particular (healthy or pathological) interest in healthy eating, the two latter groups represented those with respectively moderate and high degrees of an interest in healthy eating that has both pathological and healthy aspects. Significant differences between clusters regarding their levels of stress, depression, anxiety and self-esteem was observed, yet they were found to be negligible due to poor effect sizes.

Conclusion

Findings from this study suggest that ON and HO can indeed co-occur among adolescents, that this co-occurrence can be experienced at different severity levels. Low effect sizes for ANOVA comparisons may suggest the possibility of the co-occurrence of ON and HO reducing the negative effects of ON behavior to some degree. The potential role of confusion around what constitutes "healthy eating" in the emergence of these "in-between orthorexia" profiles is put forward.
Loss of miR-637 promotes cancer cell stemness via WASH/IL-8 pathway and serves as a novel prognostic marker in esophageal squamous cell carcinoma
Authors: Guo Mengxing , Lian Jingyao , Liu Yaqing , Dong Bo , He Qianyi , Zhao Qitai , Zhang Hongyan , Qi Yu , Zhang Yi , Huang Lan
Published: November 2022

Background

Esophageal carcinoma is the highly lethal cancer in the world, predominantly in some areas of East Asia. We previously reported that overexpression of cytoskeleton regulator Wiskott-Aldrich syndrome protein and SCAR Homolog (WASH) associates with poor prognosis of patients with esophageal squamous cell carcinoma (ESCC). However, the molecular mechanism and clinical significance involved in WASH overexpression have not been fully elucidated.

Methods

Bioinformatics analysis and luciferase reporter assay were used to predict and validate miR-637 as a regulator of WASH in ESCC cell lines. qRT-PCR, Western blotting and ELISA assays were performed to examine RNA expression and protein levels, respectively. Next, the biological functions of miR-637 were explored by tumor sphere formation assay in vitro and nude mouse tumor xenograft in vivo. Finally, we evaluated the association of miR-637 levels with clinical features in ESCC patients.

Results

We identified miR-637 as a WASH-targeting miRNA. miR-637 mimic strongly attenuated the downstream IL-8 production and tumor sphere formation in esophageal cancer cells, whereas miR-637 inhibitor displayed an opposite effect. IL-8 could facilitate stem-like properties and partially rescue the phenotypes induced by miR-637 mimic. Furthermore, miR-637 inhibitor dramatically promoted IL-8 expression and cancer stemness properties in a WASH-dependent manner. Ectopic expression of miR-637 also inhibited tumor growth in a mouse model. Clinically, low expression of miR-637 was observed in tumor tissues and the low expression levels of miR-637 were correlated with poor survival of ESCC patients. In particular, plasma miR-637 could be used as a noninvasive biomarker for ESCC patients.

Conclusions

These results implicate the potential application of miR-637 for diagnosis and prognosis of esophageal cancer.
In Vitro Study to Evaluate the Efficacy of Ultrasonicated Ethanolic Extract of Rosmarinus officinalis and its Chitosan-Based Nanoparticles Against Eimeria tenella Oocysts of Chickens
Authors: Kasem Shaimaa M. , Mira Nabila M. , Mahfouz Magdy E. , Helal Ibrahim B.
Published: November 2022

In this study, chitosan nanoparticles (CsNPs) were used as nanocarrier for ultrasonicated ethanolic extract of Rosmarinus officinalis (UEERO) as a new nanoformulation against Eimeria tenella. Herein, CsNPs have been synthesized by ionic gelation method at pH 3 (CsNPs3) and pH 5 (CsNPs5), followed by characterization of morphology, size, polydispersity index (PDI), surface charge, and loading efficiency of UEERO. An in vitro sporulation inhibition assay (10, 5, 2.5, 1.25, 0.62, 0.31, 0.15, 0.07, 0.04, 0.02, and 0.01 mg/ml normal saline solution) against E. tenella was conducted. Results showed that free CsNPs and UEERO-CsNPs3/5 were cubic- and spherical-shaped with positive charge and average size of ~ 150.8 nm (314.4 nm) and 151.7 nm (321.1 nm), respectively. The total loading efficiency using UV–vis spectrophotometer, was 80.05 at pH 5 and 64.39% at pH 3. The in vitro sporulation inhibition assay revealed that UEERO, CsNPs3/5, and UEERO-CsNPs3/5 showed a potential inhibitory effect on sporulation (%), distortion in wall (%), and sporocyst abnormality (%) in a dose-dependent manner. Accordingly, the concentration (10 mg/ml) showed the best efficacy after 24 h in UEERO, free CsNPs, and UEERO-CsNPs. Moreover, UEERO-CsNPs3 and UEERO-CsNPs5 had stopped the sporulation (%) after 72 h. Taken all together, UEERO-CsNPs3 and UEERO-CsNPs5 are best effective against E. tenella in a dose-dependent manner in terms of sporulation (%), distortion in wall (%), and sporocysts abnormality.

Graphical abstract
The Revolutionary and Anti-Capitalist Politics of the Late Foucault
Authors: Kawashima Ken
Published: November 2022

This article argues that Foucault’s analysis of ancient philosophy, ethics, and politics after 1979–1980 represents not only a discursive break or discontinuity with Foucault’s decades-long analysis of capitalism, but also an inventive series of techniques and practices to negate and overcome fundamental problems of subjectivity under historical capitalism and in revolutionary political action. Part 1 of the article returns to The Birth of Biopolitics (1978–1979) and discusses four problems that Foucault identified as problems to be negated and overcome in political action and revolution: human capital, historical capitalism, the crisis of party governmentality, and the absence of the economic sovereign in political economy. Part 2 reviews Foucault’s analysis of diakrisis, epimeleia heautou, and metanoia in relation to the absence of economic sovereignty in modern political economy and neoliberal economics, as well as in relation to Marx’s precept to “change yourselves, and prepare yourselves for the exercise of political power.” Part 3 analyzes Foucault’s concept of parrhēsia—or speaking the truth in the face of power—in relation to Marx’s vision of the dictatorship of the proletariat.
Άμεσος προσδιορισμός μόνιμης κατάστασης ταλάντωσης και διάγνωση-αναγνώριση βλαβών σε μη γραμμικά μοντέλα οχημάτων
Authors: Μεταλλίδης Πρόδρομος
Published: November 2022

Στα πλαίσια της παρούσας διατριβής αρχικά αναπτύσσονται συστηματικές αναλυτικές και αριθμητικές μεθοδολογίες για τον άμεσο προσδιορισμό της μόνιμης κατάστασης ταλάντωσης μη γραμμικών μηχανικών συστημάτων, υποκείμενων σε περιοδική φόρτιση. Στη συνέχεια αναπτύσσονται πρόσθετες αριθμητικές μεθοδολογίες για τη διενέργεια διάγνωσης-αναγνώρισης βλαβών σε τέτοια συστήματα. Οι μεθοδολογίες επιλέγεται να εφαρμοσθούν σε δυναμικά μοντέλα οχήματος. Στις εξεταζόμενες περιπτώσεις, η εξωτερική διέγερση προέρχεται είτε από γεωμετρικές ανομοιομορφίες του εδάφους ή από την πίεση των καυσαερίων που αναπτύσσεται στους κυλίνδρους του κινητήρα του οχήματος. Επιπλέον, η έμφαση δίδεται στη διερεύνηση της επίδρασης της ισχυρά μη γραμμικής συμπεριφοράς που εμφανίζεται στα χαρακτηριστικά στιβαρότητας και απόσβεσης των αναρτήσεων του οχήματος, καθώς επίσης στα χαρακτηριστικά στιβαρότητας και απόσβεσης της έδρασης του στροφαλοφόρου άξονα και των ελαστικών στοιχείων στήριξης του πλαισίου του κινητήρα.Τόσο κατά τον άμεσο προσδιορισμό περιοδικών κινήσεων, όσο και κατά την επίλυση του προβλήματος διάγνωσης και αναγνώρισης βλαβών στο σύστημα του οχήματος εμφανίζονται ιδιαίτερες αριθμητικές δυσκολίες. Αυτό συμβαίνει εξαιτίας της πολυπλοκότητας της γεωμετρίας της κατασκευής του, αλλά και της ύπαρξης και ενεργοποίησης μη γραμμικοτήτων που υπάρχουν στα χαρακτηριστικά των συνδέσμων των κατασκευαστικών μελών και συνιστωσών του οχήματος. Για το λόγο αυτό, αρχικά εφαρμόζονται μέθοδοι που αναπτύχθηκαν για σχετικά απλά μηχανικά μοντέλα, με σκοπό την εκτίμηση της αριθμητικής ακρίβειας και την επιβεβαίωση της αποτελεσματικότητάς τους. Στη συνέχεια, η εξέταση επεκτείνεται σταδιακά σε συνθετότερα μοντέλα. Τελικά, έγινε επιτυχής εφαρμογή των μεθοδολογιών σε ακριβή μοντέλα με παραμορφώσιμα μέλη, που προέρχονται από εφαρμογή της μεθόδου πεπερασμένων στοιχείων στη γεωμετρία ενός πραγματικού οχήματος και οδηγούν σε δυναμικά συστήματα με μεγάλο αριθμό βαθμών ελευθερίας.
How do new therapeutic strategies for PCOS management influence the health of the affected individuals? The narrative review
Authors: Wójcik Aleksandra , Wojtas Jan , Margas Mikołaj , Warchoł Konrad , Stępniak Karol
Published: November 2022

Introduction and purpose: Management of polycystic ovary syndrome (PCOS) is difficult since the exact pathogenic mechanism has not been established yet. Due to that fact, the substances registered to treat PCOS are still lacking efficacy and are associated with a number of adverse effects. The aim of this study is to review new possible treatment approaches.

 

State of knowledge: Inositol administered alone or combined with oral contraceptive drugs improves patients’ hormonal status and alleviates the weight increase in comparison to oral contraceptive drugs on their own. Berberine reduces insulin resistance, improves lipid metabolism, and reduces inflammatory reactions. Glucagon-like peptide-1 receptor agonists have a better weight loss effect and less severe adverse reactions than metformin. Thiazolidinediones combined with metformin improve ovulation rate, acne and increase SHGB levels. Thiazolidinediones have also less severe adverse reactions than metformin and can be useful in patients who are not able to tolerate metformin.

 

Summary: The review has shown that inositol, berberine, glucagon-like peptide-1 receptor agonists andthiazolidinediones have promising therapeutic effects in terms of PCOS treatment, however, more research is needed to establish safety and efficacy of those agents. Nonetheless, results of this study may be utilized in the education of health specialists in endocrinology departments.
Assessment of value of protraction angle and functional disorders of motion segments of cervical spine in bus drivers
Authors: Madej Aleksandra , Śliwiński Zbigniew , Wypych Żaneta , Żurawski Arkadiusz
Published: November 2022

Introduction: Cervical segment is a part of the spine which is the most exposed to stress and dysfunction.
Aim: The aim of the study is to analyze the body posture of bus drivers and, especially, functional assessment of cervical spine mobility segments.
Material and methods: The study included a group of 40 people, consisting of professionally active drivers working in public transport, 20 of whom were the men under 40, and the remaining 20 were the men over 40. The study used the original study card.
Results: There was dependence between the subjects' length of service and the appearance of hand numbness. There was dependence between protraction angle and length of service. Most of the study subjects (67.5%) report the presence of back pain syndromes. Among the study subjects, 45.0% declare that they do sports / physical activity improving their condition. In the case of rectus abdominis muscle strength, the majority of the surveyed (60.0%) cannot sit unassisted.
Conclusions: The bus driver is exposed to a lot of stress every day, resulting, i.a. from the responsibility he bears for passengers in the vehicle, as well as from heavy traffic, which leads to changes in myofascial tensioning, resulting in the incidence of pain.
Chemoembolization as a minimally invasive treatment of primary malignant liver cancer
Authors: Szklener Katarzyna , Kuryło Weronika , Rodzajewska Anna , Światłowski Łukasz , Jargiełło Tomasz , Mańdziuk Sławomir
Published: November 2022

Background: Hepatocellular carcinoma (HCC) is the most common type of liver cancer and one of the most malignant neoplasms with high incidence and mortality in humans worldwide. The complex nature of the disease and its high resistance to systemic therapies result in poor prognosis for patients with advanced HCC. 
Case Report: In March 2017, the patient was admitted to the Department of Oncological Surgery, where a non-anatomical tumor resection was performed. Three years later, the patient developed a single change in segment 8 of the liver that was a relapse of the neoplastic process. Based on the Bracelon Criteria, the patient was qualified for the 1st stage of chemoembolization using the Seldinger method. In the presented patient as a result of the applied treatment, the neoplastic process was stabilized. 
Conclusion: The chemoembolization treatment that was applied to the presented patient turned out to be the correct treatment option. After only the first stage of chemoembolization, the patient regressed the neoplastic lesion.
How to Create Learning Communities to Increase Inclusion in Higher Education Using Appreciative Inquiry
Authors: Laurie Guillaume
Published: November 2022

In 2016, Kedge Business School in France sent two of its instructional designers, Olga Boura and Guillaume Laurie, on an Appreciative Inquiry course. Combining AI with their existing skills, they created a special one-day icebreaker course to welcome their students and create the conditions students would need to enhance their social development.
Breakdowns and Breakthroughs of Intercultural JEDI Work in a Non-Profit Global Organisation
Authors: Thompson-Tan Sharon
Published: November 2022

The author, one of a group of consultants working with a non-profit organisation based in North America in the area of justice, equity, diversity and inclusion found that their breakthrough came when they began to adopt an Appreciative Inquiry approach to the work.
Risky Sure Things
Authors: Rottenstreich Yuval , Markle Alex , Müller-Trede Johannes
Published: November 2022

Decision research often takes the variability of potential outcomes as a measure of risk. It thus characterizes sure things, which, by definition, guarantee a specific outcome, as safe. But is this characterization always empirically valid? We show that, when the prevailing reference point is an uncertain option or position, sure things can be perceived as risky rather than safe. Furthermore, preferences may hinge on such perceptions: when construed as risky, sure things can be less appealing. Our findings suggest a perception-based explanation for why the classic tendency to favor sure things over uncertain options is often attenuated given an uncertain reference point. More broadly, they tap an unresolved debate about the determinants of decisions. Much research focuses on taste-based determinants, such as attitudes toward perceived risks, and thereby underplays the critical role of the underlying perceptions. Appreciating the impact of perceptions on decision making leads to novel prescriptive recommendations.

This paper was accepted by David Simchi-Levi, decision analysis.

Supplemental Material: Data and the online supplement are available at https://doi.org/10.1287/mnsc.2022.4590 .
O tempo suspenso da revolta: a liminaridade na Batalha da Rua Muhammad Mahmoud em contexto da Revolução Egípcia de 2011
Authors: Pamplona Pablo , Affonso Penna Mariana
Published: November 2022

Recentemente completados, os 10 anos da chamada Primavera Árabe evocam anseios por mudança, frustrações, atos de bravura e tragédia. Em tempos de agitação social, interesses em conflitos e sonhos, por vezes irrealizáveis, ganham espaço em formato de confronto na cena pública. A própria temporalidade regular fica suspensa, dando margem para inversões, ainda que temporárias, da ordem social. A partir de uma articulação interdisciplinar entre o trabalho da historiadora Lucie Ryzova (2020) sobre a Batalha da Rua Muhammad Mahmoud, ocorrida no contexto da Revolução Egípcia de 2011, e as teses de Walter Benjamin sobre a história (2019a), com aportes da antropologia e da psicologia social, este artigo visa traçar caminhos possíveis para uma leitura crítica da ideia de liminaridade em tempos de revolta popular. Ao dialogar essas duas abordagens, identifica-se uma diferença significativa em formas de análise teórica de períodos de revolta, em particular a possibilidade da revolta como fim em si mesma ou como parte de um projeto maior de emancipação social.
Coringas da literatura: Emergência dos(as) os(as) Agentes Literários(as) Profissionais no Brasil
Authors: Pocai Stella Marcello Giovanni
Published: November 2022

Um(a) novo(a) profissional ganhou mais espaço no mundo literário no final do século XX e início do século XXI. Nesse período, o Brasil começou a ver surgir mediadores chamados(as) agentes literários(as), que alteraram o panorama das publicações brasileiras. Este artigo busca compreender a emergência desses agentes olhando para suas trajetórias sociais e profissionais, bem como sua inserção no campo literário brasileiro contemporâneo.
APROXIMAÇÃO EM TEMPOS DE DISTANCIAMENTO: MUSEUS EM CONTEXTOS VIRTUAIS DURANTE A PANDEMIA
Authors: Carvalho Cristina , Campolina de Azeredo Coutinho Lopes Gabriela
Published: November 2022

O presente artigo tem como objetivo dialogar teoricamente com o conceito de museu, educação museal e educação museal on-line, considerando o contexto específico de pandemia. São apresentados dois casos de digitalização de exposições de museus universitários e análise de uma instituição: o Museu do Isolamento Brasileiro, espaço totalmente digital, inaugurado durante a pandemia na rede social Instagram. Considerando a presença cada vez maior de museus digitais, inclusive através de redes sociais, propõe-se uma discussão sobre o que é museu, partindo do conceito apresentado pelo ICOM em 2009, que está atualmente sendo rediscutido, e elaboração de hipóteses sobre o cenário museológico durante e após o período pandêmico. Para a elaboração do artigo, foi realizada uma revisão de bibliografia sobre a temática de educação museal, museologia social, redes sociais e o contexto da pandemia. Tomando como caso de análise a fundação do Museu do Isolamento Brasileiro, foi realizada uma entrevista estruturada com a fundadora do museu por meio da plataforma digital Whatsapp. Com o desenvolvimento do estudo, foi possível concluir que processos de digitalização dos espaços museais já estavam presentes antes da pandemia, porém, foram intensificados por conta do cenário apresentado, sendo então apresentadas novas possibilidades do que é ser museu no século XXI.
EDUCAÇÃO MUSEAL EM TEMPOS PANDÊMICOS: O QUE APRENDEMOS?
Authors: Chiovatto Milene , Aidar Gabriela , Oliveira Margarete De , Dos Santos Wilmihara Benevides da Silva Alves , Farinha Vera Lucia Cardoso
Published: November 2022

O presente texto reflete sobre os processos de reconstrução e transformação aos quais os educativos de museus estiveram sujeitos durante o período de distanciamento social promovido em combate à pandemia da COVID 19. Utilizaremos como exemplo para as reflexões as experiências desenvolvidas pelo Núcleo de Ação Educativa da Pinacoteca de São Paulo.
TRILHANDO CAMINHOS ALTERNATIVOS DE FORMAÇÃO NO CONTEXTO DA PANDEMIA DA COVID-19: UM RELATO DE EXPERIÊNCIA SOBRE UMA AÇÃO DE EXTENSÃO SOLIDÁRIA E COLABORATIVA
Authors: Lopes Pablo Matheus da Silva , Guedes Dimitri Taurino , Castro Kamilla Maria Sousa de
Published: November 2022

A crescente interação mediada pelas tecnologias da informação e comunicação (TICs) expressa o surgimento de um novo universo, no qual a ideia de limite ou fronteira da comunicação é superada pelos espaços virtuais. No atual contexto de suspensão das atividades presenciais imposta pela pandemia da COVID-19, tal situação foi reforçada, haja vista a possibilidade de continuar estabelecendo vínculos virtuais permanentes entre as pessoas. No cenário da educação brasileira, observamos um setor que foi impelido a reinventar-se para dar continuidade às atividades por meio do Ensino Remoto Emergencial (ERE). Neste sentido, este relato de experiência objetiva promover uma reflexão crítica acerca da formação discente em modalidade remota, considerando as contribuições de uma ação de extensão desenvolvida em um Campus da Universidade Federal do Rio Grande do Norte (UFRN) no município de Santa Cruz/RN, com foco na saúde do trabalhador e na mobilização da economia local no contexto da pandemia.
DESENHO DIDÁTICO DE CURSO DE FORMAÇÃO CONTINUADA DE PROFESSORES DURANTE O ENSINO REMOTO EMERGENCIAL
Authors: Alves Elaine Jesus
Published: November 2022

A partir do conceito de desenho didático interativo (SANTOS & SILVA, 2009), o artigo apresenta a experiência da concepção, desenho e oferta do curso de pós-graduação em Educação online, recursos interativos e colaborativos na Universidade Federal do Tocantins no ano de 2021/2022 com a pandemia de Covid-19 em andamento e as aulas presenciais suspensas. A primeira parte do texto aborda o protagonismo dos professores que mesmo diante do desconhecido, buscaram adaptar-se ao ensino remoto emergencial. Em seguida ressalta a importância dos cursos de formação inicial e continuada na área de tecnologia educativa e apresenta um modelo de desenho didático que contempla as habilidades e competências necessárias para a atuação docente no mundo pós-pandemia. O artigo finaliza apresentando a experiência do curso supracitado apontando os pontos fortes de formações que contemplam a integração das tecnologias permeadas por atividades colaborativas e interativas
ENSINO REMOTO EMERGENCIAL: PERCEPÇÕES DE PROFESSORES DA EDUCAÇÃO INFANTIL EM PALMAS (TO)
Authors: Da Silva Anadir Ferreira , Abreu Cirley Bandeira de , Melo Luciléia dos Santos de
Published: November 2022

O presente artigo é um desdobramento da pesquisa desenvolvida na Educação de Palmas/TO na pandemia da Covid-19 em 2022. Nele, buscamos compreender a percepção docente frente às experiências vivenciadas durante a pandemia no ensino da Educação Infantil. O embasamento teórico fundamenta-se em autores contemporâneos que abordam o ensino remoto e suas implicações no período pandêmico, buscando apontar os principais desafios encontrados e diferentes metodologias de ensino aplicadas. Fizemos o uso da pesquisa aplicada, e mobilizamos o instrumento de pesquisa questionário, contendo perguntas abertas e fechadas, visando capturar fragmentos das impressões e das experiências nas aulas remotas. Como resultado desta pesquisa, destacamos que apesar das dificuldades encontradas, notamos que os professores buscaram promover uma educação genuína, autêntica e contextualizada.
"O TRABALHO QUE O EDUCADOR FAZ É IR ALÉM": UMA CONVERSA SOBRE EDUCAÇÃO MUSEAL COM DENISE PEIXOTO, EDUCADORA DO MUSEU PAULISTA
Authors: Peixoto Denise Cristina Carminatti , Souza Aline Miranda e , Castro Aline Rocha de Souza Ferreira de
Published: November 2022

A conversa com Denise Peixoto abordou aspectos relacionados à sua trajetória enquanto educadora da Universidade de São Paulo - USP, atuando no Museu de Arqueologia e Etnologia/USP e no Museu Paulista/USP, que, após 8 anos com suas exposições fechadas ao público, reabrirá em setembro de 2022. Formada em História, com mestrado em Arqueologia, narra como a sua aproximação com a Arqueologia influenciou seu modo de atuação como educadora. A conversa abordou temas envolvendo as especificidades de atuação em um museu universitário, relação com o corpo docente, a importância dos discentes e da diversidade de cursos, as possibilidades múltiplas de atuação de um educador em museus, acessibilidade, inclusão e seus desafios e finaliza com algumas palavras para quem quiser se tornar um educador museal.
DESAFIOS VIVENCIADOS NO ENSINO REMOTO/QUESTÕES TECNOLÓGICAS: REESTRUTURANDO O PLANEJAMENTO PEDAGÓGICO
Authors: Lopes Reis Mírian Gomes , Sousa Denise Dias de Carvalho , Gomes Antenor Rita
Published: November 2022

Os recursos tecnológicos não têm suprido as carências nas práticas dos/as professores/as no ensino remoto, de forma satisfatória e efetiva nas escolas públicas de educação básica. Não é fácil enfrentar os muitos desafios desse momento pandêmico e, analisando esse contexto de isolamento e distanciamento social, onde imperam o medo e a insegurança, a educação não pode ser deixada para outro momento. Dessa forma, a educação atual exige mudanças na postura de todos os evolvidos no processo ensino e aprendizagem, principalmente, nas atitudes dos docentes, que devem ser os responsáveis em elaborar os materiais didáticos destinados às práticas pedagógicas, no ensino remoto, presencial ou híbrido e/ou nas aulas invertidas. Assim, este trabalho tem como objetivo contribuir para uma análise crítica da realidade educacional vigente nas escolas de educação básica. Os pressupostos teóricos estão pautados na teoria e na prática do ensino remoto, na visão de professoras-egressas do curso de Pedagogia do PARFOR, através das entrevistas narrativas e dos grupos de discussão. Para tanto, tomamos como base os estudos de Lima (2021), Ramos (2021), Pimenta (1998, 2002, 2005), Libâneo (2013), Freire (2008), entre outros, numa abordagem qualitativa de análise dos dados. Os resultados revelaram desafios e possibilidades para o exercício efetivo e eficaz das práticas pedagógicas no ensino remoto, contribuindo, dessa forma, para um olhar reflexivo na formação docente.
DESAFIOS E POSSIBILIDADES DO ESTÁGIO SUPERVISIONADO EM EDUCAÇÃO FÍSICA: A EXPERIÊNCIA COM O ENSINO HÍBRIDO
Authors: Barbosa Milena Cristian do Nascimento , Almeida Márcia Taynara Machado , Farias Mayrhon José Abrantes , Souza Adriano Lopes de
Published: November 2022

O presente artigo objetiva relatar as experiências vividas por acadêmicas do curso de Licenciatura em Educação Física durante o do Estágio Supervisionado em uma escola pública no município de Tocantinópolis-TO. Nesse trabalho utilizamos a narrativa autobiográfica para abordar os desafios e as possibilidades vivenciadas no modelo de Ensino Híbrido, problematizando a didática utilizada nos portfólios e propondo reflexões quanto ao papel da Educação Física em meio a um contexto de ensino fragilizado, incluindo os respectivos impactos nas práticas corporais/atividades realizadas na escola. A partir dessa experiência, foi possível perceber a importância do uso de outras linguagens, para além da escrita, na apropriação dos conhecimentos que cerceiam o cotidiano escolar, de forma geral, e os momentos das aulas de Educação Física, de forma particular.