bluuebunny/crossref_metadata_2025 huggingface dataset:
Imatinib Resistance in Chronic Myeloid Leukemia Associated with a D363G BCR::ABL1 Kinase Domain Mutation
Authors: Langabeer Stephen E. , Macleod Stuart , Bhreathnach Úna , Fadalla Kamal
Published: April 2023

Acquired resistance to tyrosine kinase inhibitors (TKIs) remains a therapeutic challenge in the treatment of chronic myeloid leukemia (CML). The most studied reason for TKI resistance is the acquisition of mutations within the BCR::ABL1 tyrosine kinase domain (KDM) and of which the majority of which occur at seven codons within this region. A case of CML is described in which presence of a rare D363G BCR::ABL1 KDM resulted in a suboptimal response to frontline imatinib. Switching to dasatinib resulted in achieving a sustained major molecular response that was maintained after a subsequent switch to bosutinib due to the side effects. Reporting of such cases is important for the future management of any CML patients with this rare mutation.
Effects of Auricular Point Acupressure with Lifestyle Interventions on Cerebrovascular Function among Adults with High Stroke Risk: A Randomized Controlled Study
Authors: Luo Le , Huang Liu , Han Shi-Jie , Wu Du , Qian Yue , Jiang Ke-Qin , Yang Lei
Published: April 2023

Background. To investigate the potential benefits of the auricular point acupressure on cerebrovascular function and stroke prevention among adults with high stroke risk. Methods. A randomized controlled study was performed in 105 adults at high risk for stroke between March and July 2021. Participants were randomly allocated (1 : 1) to receive either auricular point acupressure with basic lifestyle interventions (n = 53) or basic lifestyle interventions alone (n = 52) for 2 weeks. The primary outcome was the kinematic and dynamic indices of cerebrovascular function, as well as CVHP score at week 2, measured by the Doppler ultrasonography and pressure transducer on carotids. Results. Among the 105 randomized subjects, 86 finished the intervention plans. At week 2, the auricular point acupressure therapy with lifestyle intervention group had higher kinematic indices, cerebrovascular hemodynamic parameters score and lower dynamic indices than the lifestyle intervention group. Conclusions. Cerebrovascular function and cerebrovascular hemodynamic parameters score were greater improved among the participants undergoing auricular point acupressure combined with lifestyle interventions than lifestyle interventions alone. Hence, the auricular point acupressure can assist the stroke prevention. Trail Registration. This trial registered with ChiCTR2100041769 on https://www.chictr.org.cn/.
Incremental Mining Method of Warehouse Operation Process in Production Enterprises Based on Swarm Intelligence
Authors: Ding Song , Li Jun , Li Jiye
Published: April 2023

In order to improve the scheduling ability of production enterprise warehouse operation, an incremental mining algorithm of production enterprise warehouse operation process based on swarm intelligence algorithm is proposed. The particle swarm optimization method is used to sample the environmental information of the warehouse operation area of the production enterprise, and the collected data of the warehouse operation area of the production enterprise are dynamically weighted, and the shortest path optimization control is carried out. Particle swarm optimization (PSO) is used to detect the shortest path for incremental mining and block search of warehouse operation process in production enterprises, and the pheromone feature quantity of incremental mining of warehouse operation process in production enterprises is extracted. Through the adaptive optimization process of incremental mining of warehouse operation process of production enterprises, incremental mining and shortest optimization control of warehouse operation process of production enterprises are realized. The simulation results show that the optimization ability of incremental mining of warehouse operation process of production enterprises using this method is better, which improves the response ability of warehouse operation of production enterprises and reduces the time cost of delivery.
Thermal Adsorption and Mechanical Behaviour of Polypropylene Hybrid Composite Synthesized by Glass/Hemp Fibre via an Injection Moulding Process
Authors: Venkatesh R. , Kantharaj I. , Sasikumar R. , Kannan C. Ramesh , Yadav Anupam , Karthigairajan M. , Vivekanandan P. , Murugan Arundeep
Published: April 2023

Thermoplastic-based polymers are gathering importance in several engineering fields like electrical, electronic, automotive, aerospace, and structural. The additions of secondary phase reinforcements such as natural and synthetic fibre improve thermoplastic-based polymer’s properties. The thermoplastic and natural fibre combinations are found to have low mechanical strength and incompatibility and need special treatment for synthesizing the natural fibre. The present experimental investigation deals with the enhancement of polypropylene hybrid composite by using the combinations of glass (synthetic)/hemp (natural) fibre for the ratio of 0 : 35, 5 : 30, 10 : 25, and 15 : 20 reinforced with 5 wt% compatibilizer through injection moulding. The revealed test results of polypropylene hybrid composite showed improved mechanical impact and flexural and tensile strength of 37.5%, 14.2%, and 21.1%, respectively. The thermal adsorption characteristics were evaluated by thermogravimetric analysis apparatus. It showed the decomposition of composite limited by hemp fibre at 27°C to 700°C.
Analysis of Optimal Load Management Using a Stand-Alone Hybrid AC/DC Microgrid System
Authors: Subramanian Vasantharaj , Vairavasundaram Indragandhi , Aljafari Belqasem
Published: April 2023

Typically, diesel or other fossil fuel-based related applications meet electricity demand. Nonetheless, as the cost of fossil fuels rises, as do their harmful emissions, there is a sudden transition toward stand-alone hybrid renewable energy systems (HRESs). The proposed project proposes electrifying VIT University in Vellore, Tamil Nadu, India, using an off-grid HRES. The goal of enhancing hybrid energy system (HES) regulation, size, and component selection is to provide society with a cost-effective power supply. This article’s primary purpose is to show how to utilize HOMER Pro Software to reduce total net present cost, cost of energy, and CO2 emissions. After that, the findings were compared to four different HRES configurations. The efficient solution for transmitting power at the lowest energy cost is configuration 1 (solar + fuel cell + battery + wind + diesel generator) which is found to be the optimal solution for supplying energy with 0% unmet load at the least cost of energy, which is at 24.91 Rs/kWh. These data are used to calculate the optimal size of energy storage components based on long-term system behavior using HOMER and to forecast short-term generation and demand changes while maintaining system dependability and grid voltage. Using and incorporating model predictive control (MPC) for an interlinking converter (ILC), the proposed HRES design is validated for the study area in a novel way that sequentially applies HOMER and MATLAB simulations.
Characterization of Copper Oxide–Jatropha Oil Nanofluid as a Secondary Refrigerant
Authors: Gobane Seboka , Dama Tesfaye , Hasan Nasim , Yanmaz Ekrem
Published: April 2023

Nanofluid is a new fluid with special characteristics that can be used in various industrial heat transfer applications. The nanofluid was created using the two-step approach of dispersing nanoparticles into Jatropha oil. The experiments were conducted for four samples of mixture nanofluid at four different volume concentrations of 0.5%, 1.0%, 1.5%, and 2%. The nanoparticles were characterized by X-ray diffractometric analysis, X-ray fluorescence spectroscopy, and scanning electron microscopy. The greatest increase in thermal conductivity for CuO–Jatropha oil nanofluids was made possible by 0.5%, 1.0%, 1.5%, and 2% mixture was 4.5%, 6.01%, 7.6, and 9.1%. The study observed that a mixture achieved the highest thermal conductivity for nanofluid at 2%. At a mixture of 0.5%, the lowest value of thermal conductivity within the range under consideration, a “deeding” effect was seen. To determine the thermal conductivity of CuO–Jatropha oil nanofluids based on temperature, volume concentration, and nanoparticle mixture volume concentrations, the study suggested and compared four sample models. The effect of nanoparticles on the rise of thermal conductivity and viscosity was investigated at temperatures ranging from 298 to 323 K. The X-ray diffractometer is used to characterize nanoparticles. Viscosity and thermal conductivity have been tested in the lab. The findings show that the copper oxide nanoparticles improved the base fluid’s thermophysical abilities more than Jatropha oil alone. For the evaluation of the thermal conductivity and viscosity of nanofluid, new empirical correlations were presented based on experimental data. The thermal conductivity of the nanofluids increases as the temperature rises, while the viscosity of the nanofluids decreases.
Protective Effects of a Polyphenolic Phytochemical Quercetin against Oxidative Dysfunctions in Rats
Authors: Foudah Ahmed I. , Salkini Mohammad A. , Yusufoglu Hasan Soliman , Alkreathy Huda Mohammed , Khan Rahmat Ali
Published: April 2023

Background. Quercetin hastraditionally been used in various oxidative and urinary tract dysfunctions. Thecurrent project is consequently set to evaluate the defensive efficacy ofQuercetin against potassium bromate (KBrO3) induced testiculartissue oxidative dysfunctions through biochemical, hormonal, and genotoxicmarkers.Methods. To observe theprotective efficacy of Quercetin against urinogenital oxidative dysfunction inrats, thirty six albino male rats were divided into six groups. Protectiveefficacies of Quercetin were checked on reproductive hormonal levels,antioxidant enzyme activities, lipids peroxidation (LP), and DNA damages. Results. Potassium bromate exposure in experimentalanimals caused a reduction in the activities of antioxidant enzymes and disturbedhormonal secretions while enhancing the peroxidation of lipids andfragmentations of DNA. Cotreatment of Quercetin considerably (P<0.01)reversed these abnormalities with admiration to levels of hormones, antioxidantenzymes activities, and peroxidations of lipids secure to those seen inuntreated rats. (P < 0.01) Conclusion. The findings of the current project revealedthat various doses of Quercetin are able to keep the testicular organ fromabnormal free radical dysfunctions. These improvements might be due to theantioxidant ability of polyphenolic bioactive constituent, i.e., Quercetin.
The Diagnostic Power of Circulating miR-1246 in Screening Cancer: An Updated Meta-analysis
Authors: Huynh Khanh Quang , Le Anh Tuan , Phan Thang Thanh , Ho Toan Trong , Pho Suong Phuoc , Nguyen Hang Thuy , Le Binh Thanh , Nguyen Thuc Tri , Nguyen Son Truong
Published: April 2023

Background. MicroRNA-1246 (miR-1246), an oncomiR that regulates the expression of multiple cancer-related genes, has been attracted and studied as a promising indicator of various tumors. However, diverse conclusions on diagnostic accuracy have been shown due to the small sample size and limited studies included. This meta-analysis is aimed at systematically assessing the performance of extracellular circulating miR-1246 in screening common cancers. Methods. We searched the PubMed/MEDLINE, Web of Science, Cochrane Library, and Google Scholar databases for relevant studies until November 28, 2022. Then, the summary receiver operating characteristic (SROC) curves were drawn and calculated area under the curve (AUC), diagnostic odds ratio (DOR), sensitivity, and specificity values of circulating miR-1246 in the cancer surveillance. Results. After selection and quality assessment, 29 eligible studies with 5914 samples (3232 cases and 2682 controls) enrolled in the final analysis. The pooled AUC, DOR, sensitivity, and specificity of circulating miR-1246 in screening cancers were 0.885 (95% confidence interval (CI): 0.827-0.892), 27.7 (95% CI: 17.1-45.0), 84.2% (95% CI: 79.4-88.1), and 85.3% (95% CI: 80.5-89.2), respectively. Among cancer types, superior performance was noted for breast cancer (

AUC
=
0.950
,
DOR
=
98.5

) compared to colorectal cancer (

AUC
=
0.905
,
DOR
=
47.6

), esophageal squamous cell carcinoma (

AUC
=
0.757
,
DOR
=
8.0

), hepatocellular carcinoma (

AUC
=
0.872
,
DOR
=
18.6

), pancreatic cancer (

AUC
=
0.767
,
DOR
=
12.3

), and others (

AUC
=
0.887
,
DOR
=
27.5
,
P
=
0.007

). No significant publication bias in DOR was observed in the meta-analysis (funnel plot asymmetry test with

P
=
0.652

;

skewness
 
value
=
0.672

,

P
=
0.071

). Conclusion. Extracellular circulating miR-1246 may serve as a reliable biomarker with good sensitivity and specificity in screening cancers, especially breast cancer.
What Is the Place of Intermediate Care Unit in Patients with COVID-19? A Single Center Experience
Authors: Bülbül Hale , Derviş Hakim Gözde , Ceylan Cengiz , Aysin Murat , Köse Şükran
Published: April 2023

Introduction. COVID-19 pandemic has led to an increased rate of intensive care unit (ICU) stays. Intermediate care units (IMCUs) are a useful resource for the management of patients with severe COVID-19 that do not require ICU admission. In this research, we aimed to determine survival outcomes and parameters predicting mortality in patients who have been admitted to IMCU. Materials and Methods. Patients who were admitted to IMCU between April 2019 and January 2021 were analyzed retrospectively. Sociodemographics, clinical characteristics, and blood parameters on admission were compared between the patients who died in IMCU and the others. Blood parameters at discharge were compared between survived and deceased individuals. Survival analysis was performed via Kaplan–Meier analysis. Blood parameters predicting mortality were determined by univariate and multivariate Cox regression analysis. Results. A total of 140 patients were included within the scope of this study. The median age was 72.5 years, and 77 (55%) of them were male and 63 (45%) of them were female. A total of 37 (26.4%) patients deceased in IMCU, and 40 patients (28.5%) were transferred to ICU. Higher platelet count (HR 3.454; 95% CI 1.383–8.625;

p
=
0.008

), procalcitonin levels (HR 3.083; 95% CI 1.158–8.206;

p
=
0.024

), and lower oxygen saturation (HR 4.121; 95% CI 2.018–8.414;

p
<
0.001

) were associated with an increased risk of mortality in IMCU. At discharge from IMCU, higher procalcitonin levels (HR 2.809; 95% CI 1.216–6.487;

p
=
0.016

), lower platelet count (HR 2.269; 95% CI 1.012–5.085;

p
=
0.047

), and noninvasive mechanic ventilation requirement (HR 2.363; 95% CI 1.201–4.651;

p
=
0.013

) were associated with an increased risk of mortality. Median OS was found as 41 days. The overall survival rate was found 40% while the IMCU survival rate was 73.6%. Conclusions. IMCU seems to have a positive effect on survival in patients with severe COVID-19 infection. Close monitoring of these parameters and early intervention may improve survival rates and outcomes.
Numerical Simulation of Flood Control Levee Deformation by Shield Tunnel Excavation through the Liuyang River: A Case Study
Authors: Lin Qibin , Cao Ping , Dong Tao , Liu Jingshuo , Zhao Qingxiong , Zhu Wenbo
Published: April 2023

The interval section of the Liuyang River flood control levee project of the Changsha Metro Line 6 is used as the engineering background of this study. A three-dimensional finite element numerical model of a tunnel shield containing complex interfaces is established by using the multifield coupling software COMSOL. The paper studied the deformation of flood control levees under shield tunnel excavation working conditions. The results show that when the left line shield machine is excavated below the Liuyang River flood control levee, the deformation of the flood control levee and the surrounding rock of the tunnel is biased towards the built right line tunnel. And it has an impact on the bridge pile near the tunnel. When the shield of the left line crosses the flood control levee, it can easily cause a large deformation and displacement of the levee above the area between the two shields. To ensure the controlled deformation of the levee, the construction should ensure the spacing between the two tunnel palm faces as far as possible and should be far away from other structures on the levee. When the shield crosses the levee, the deformation that occurs at the base of the levee is significantly higher than the deformations that occur at other locations of the levee. Displacement monitoring and secondary reinforcement at the base of the flood control levee appear to be necessary. The numerical simulation results validate the feasibility of using the multifield coupling software COMSOL to study the construction modeling of shield tunnels through rivers and its advantages. This method provides a practical framework for similar tunnel performance engineering or displacement monitoring in future projects.
Nourishing Kidney Promoting Ovulation Decoction (NKPOD) Attenuates Polycystic Ovary Syndrome by Downregulating miRNA‐224
Authors: Guo Yinhua , Tong Xingli , Tang Peipei , Zuo Wenting , Tan Yong
Published: April 2023

Background. Currently, exploring effective agents is urgently required for polycystic ovary syndrome (PCOS) treatment. Although nourishing kidney promoting ovulation decoction (NKPOD) as a traditional Chinese medicine decoction is widely employed to increase pregnancy rates, whether NKPOD attenuates ovulation disorders in PCOS patients remains unknown. Here, we aim to explore the clinical significance and the underlying mechanisms of NKPOD in ovulation disorders. Methods. PCOS patients were recruited to confirm the clinical significance of NKPOD in attenuating ovulation disorder. Subsequently, regulation targets of NKPOD were identified through network pharmacology analysis. Additionally, a series of experiments were performed to observe the impacts of NKPOD on miRNA‐224 transcription through transcription factor AR. Results. In this study, NKPOD administration improved hormone dysregulation and reproductive outcomes in PCOS patients. Interestingly, 100 potential targets related to NKPOD and PCOS were screened, and transcription regulation was observed to be the most enriched function. Mechanistically, NKPOD inhibited miRNA‐224 transcription through reducing AR expression, in which AR as a transcription factor directly regulated miRNA‐224 transcription. Conclusions. Collectively, these findings highlight the therapeutic effect of NKPOD on PCOS, which could provide promising therapeutic agents for PCOS.
Hippo Pathway in Schwann Cells and Regeneration of Peripheral Nervous System
Authors: Wang Jingyuan , Chen Haofeng , Hou Wulei , Han Qingjian , Wang Zuoyun
Published: April 2023

Hippo pathway is an evolutionarily conserved signaling pathway comprising a series of MST/LATS kinase complexes. Its key transcriptional coactivators YAP and TAZ regulate transcription factors such as TEAD family to direct gene expression. The regulation of Hippo pathway, especially the nuclear level change of YAP and TAZ, significantly influences the cell fate switching from proliferation to differentiation, regeneration, and postinjury repair. This review outlines the main findings of Hippo pathway in peripheral nerve development, regeneration, and tumorigenesis, especially the studies in Schwann cells. We also summarize other roles of Hippo pathway in damage repair of the peripheral nerve system and discuss the potential future research which probably contributes to novel therapeutic strategies.
Developmental Brain Injury and Social Determinants of Health: Opportunities to Combine Preclinical Models for Mechanistic Insights into Recovery
Authors: Guez-Barber Danielle , Eisch Amelia J. , Cristancho Ana G.
Published: April 2023

Epidemiological studies show that social determinants of health are among the strongest factors associated with developmental outcomes after prenatal and perinatal brain injuries, even when controlling for the severity of the initial injury. Elevated socioeconomic status and a higher level of parental education correlate with improved neurologic function after premature birth. Conversely, children experiencing early life adversity have worse outcomes after developmental brain injuries. Animal models have provided vital insight into mechanisms perturbed by developmental brain injuries, which have indicated directions for novel therapeutics or interventions. Animal models have also been used to learn how social environments affect brain maturation through enriched environments and early adverse conditions. We recognize animal models cannot fully recapitulate human social circumstances. However, we posit that mechanistic studies combining models of developmental brain injuries and early life social environments will provide insight into pathways important for recovery. Some studies combining enriched environments with neonatal hypoxic injury models have shown improvements in developmental outcomes, but further studies are needed to understand the mechanisms underlying these improvements. By contrast, there have been more limited studies of the effects of adverse conditions on developmental brain injury extent and recovery. Uncovering the biological underpinnings for early life social experiences has translational relevance, enabling the development of novel strategies to improve outcomes through lifelong treatment. With the emergence of new technologies to analyze subtle molecular and behavioral phenotypes, here we discuss the opportunities for combining animal models of developmental brain injury with social construct models to deconvolute the complex interactions between injury, recovery, and social inequity.
Somos todos Laika: o teatro, a morte e a condição humana uivando para o infinito: Suzana Schmidt Viganó entrevista Marcelo Soler
Authors: Viganó Suzana Schmidt , Soler Marcelo
Published: April 2023

A professora e pesquisadora Suzana Schmidt Viganó entrevista o professor, pesquisador e diretor da Cia. Teatro Documentário, Marcelo Soler. Nesta entrevista, conversamos sobre processos artísticos e pedagógicos que trazem como ponto de partida o tema da morte em diferentes âmbitos, proporcionando a investigação sobre a experiência teatral com atores e não atores, professores e crianças, dialogando artística, filosófica e socialmente com a questão da morte na sociedade contemporânea.
Morrer é uma ação nua: Orfeo: eine Sterbeübung (2015), de Susanne Kennedy
Authors: Souza Maurício Augusto Perussi de
Published: April 2023

O artigo examina o espetáculo/instalação Orfeo: eine Sterbeübung, concebido pela encenadora alemã Susanne Kennedy para a Ruhrtriennale 2015. Partindo de L'Orfeo (1607), de Claudio Monteverdi, a obra consiste em uma experiência imersiva na qual o espectador, percorrendo uma série de salas nas quais confronta atores silenciosos e mascarados, é convidado a pôr em prática um “exercício de morrer”. Procura-se esmiuçar o sentido desse exercício, tendo por base a hipótese de que a experiência de morte almejada por Kennedy tem início no desnudamento das ações, perpassando a sensibilização às “emoções automoventes”, o contato com a materialidade do tempo, desembocando, por fim, em um devir-mulher, ou no devir-Eurídice de Orfeu. No encadeamento desses conceitos, delineia-se uma correlação entre a apresentação de ações desenredadas da mímesis dramática e a possibilidade de se gerar variações em relação aos padrões majoritários de percepção.
As teias epistolares de José Enrique Rodó como testemunho da Revista Nacional de Literatura y Ciencias Sociales (1895-1897)
Authors: Santos Elisângela da Silva
Published: April 2023

In this article we aim to revisit a key moment in the epistolary dialogue of the Uruguayan thinker José Enrique Rodó (1871-1917): the interregnum 1895-1897, a period in which the work of the then young writer was turned to the editorial project of the Revista Nacional de Literatura y Ciencias Sociales. By placing Rodó at the epicenter of the relationship web built around the missives and the Revista Nacional, we will analyze how the correspondences received by him, kept in his Archive, can be read as legitimizers of his trajectory in the pedagogical exercise of literary criticism, and at the same time, they reveal his performance as an intellectual power for authors from different parts of the continent, interested in sharing ideas and projects in favor of the production of knowledge about Latin America at that time.
Trib1
Deficiency Promotes Hyperlipidemia, Inflammation, and Atherosclerosis in LDL Receptor Knockout Mice
Authors: Arndt Lilli , Hernandez-Resendiz Ileana , Moos Doreen , Dokas Janine , Müller Silvana , Jeromin Franziska , Wagner Richard , Ceglarek Uta , Heid Iris M. , Höring Marcus , Liebisch Gerhard , Stadler Sonja C. , Burkhardt Ralph
Published: April 2023

Background:

Genetic variants at the
TRIB1
gene locus are strongly associated with plasma lipid traits and the risk of coronary artery disease in humans. Here, we analyzed the consequences of
Trib1
deficiency on lipid metabolism and atherosclerotic lesion formation in atherosclerosis-susceptible
Ldlr
−/−
mice.

Methods:

Trib1
−/−
mice were crossed onto the
Ldlr
−/−
background to generate double-knockout mice (
Trib1
−/−
Ldlr
−/−
) and fed a semisynthetic, modified AIN76 diet (0.02% cholesterol and 4.3% fat) until 20 weeks of age.

Results:

Trib1
−/−
Ldlr
−/−
mice had profoundly larger (5.8-fold) and more advanced atherosclerotic lesions at the aortic root as compared with
Trib1

+/+

Ldlr
−/−
controls. Further, we observed significantly elevated plasma total cholesterol and triglyceride levels in
Trib1
−/−
Ldlr
−/−
mice, resulting from higher VLDL (very-low-density lipoprotein) secretion. Lipidomics analysis revealed that loss of
Trib1
altered hepatic lipid composition, including the accumulation of cholesterol and proinflammatory ceramide species, which was accompanied by signs of hepatic inflammation and injury. Concomitantly, we detected higher plasma levels of IL (interleukin)-6 and LCN2 (lipocalin 2), suggesting increased systemic inflammation in
Trib1
−/−
Ldlr
−/−
mice. Hepatic transcriptome analysis demonstrated significant upregulation of key genes controlling lipid metabolism and inflammation in
Trib1
−/−
Ldlr
−/−
mice. Further experiments suggested that these effects may be mediated through pathways involving a C/EPB (CCAAT/enhancer binding protein)-PPARγ (peroxisome proliferator-activated receptor γ) axis and JNK (c-Jun N-terminal kinase) signaling.

Conclusions:

We provide experimental evidence that
Trib1
deficiency promotes atherosclerotic lesion formation in a complex manner that includes the modulation of lipid metabolism and inflammation.
Designing Enactive Co-Presence: Second-Order Simulation of Empathy for Artificial Humans in Narrative Contexts
Authors: Tikka Pia , McNamara Robert G. , Gerry Lynda Joy , Kosunen Ilkka , Kaipainen Mauri
Published: April 2023

Human interactions with human-like Computer-Generated Others (CGOs) have continued to become more prevalent in the rush to technologize societies. As such, the need for close analysis of mediative dynamics between humans and CGOs has become compelling. Relying on the theoretical framework of embodied enactive cognition, this paper will discuss designing human empathetic experiences of co-presence with CGOs. We propose a two-level idea of enactive simulation: the assumption of the first-order simulation (human simulating other) is built on the holistic assumption that humans understand others thanks to shared physical embodiment and enactive situatedness, while second-order simulation (designer simulating human simulating other) is the cognitive-affective means of the designer of human–machine encounters to apply their own first-order experiences to simulate the simulation of the Experiencer. Our key assumption is that context is the defining component of co-presence, thereby allowing experimental situations of co-presence to be contextualized by means of mediated narratives. The case study experiment, Booth, designed to model affective-cognitive experiences of co-presence at encounters of human Experiencers with two artificial asylum seekers, allowed us to identify different factors of the dynamics influencing the experience of empathy and the ensuing decisions concerning asylum, in particular, the contextualizing narrative.
Eyes over stomach: companion dogs choose the larger quantity by sight, irrespective of the actual reward eaten
Authors: Loconsole Maria , Regolin Lucia , Marliani Giovanna , Mattioli Michela , Pietschmann Elena , Accorsi Pier Attilio , Normando Simona
Published: April 2023

Domestic dogs tested in a free-choice task between two sets of food prefer that of a larger quantity. A recent study pointed out the critical role of the first trial. Dogs succeeded only after being allowed at least once to eat the selected food. Here we explore the importance of the actual experience of consuming the selected reward on dogs’ capability to redirect their choice to solve numerical discriminations. Dogs tested in the 2 vs 4 and 1 vs 8 comparisons could never consume the quantity selected but always obtained a single dogs’ treat. Despite never experiencing a difference in the eaten quantity, dogs discriminated between the two sets, preferring the larger. Whereas they behaved at chance at first choice, they successfully redirected their preference toward the larger set already on their second trial. We discuss our results in terms of motivational biases toward the larger quantity that can bear relevant ecological value.
Al-Muʾtaman ibn Hūd in Context: Kingship and Philosophy in al-Andalus (10th-11th Centuries)
Authors: Forcada Miquel
Published: April 2023

In the Islamic world, the idea of the “philosopher-king” became a relevant theme particularly from the tenth century onwards. Al-Fārābī, the political philosopher of Islam par excellence, discussed the perfect city ruled by the philosopher-king along the lines of Plato. Although al-Fārābī’s political thinking is susceptible to various interpretations, it contains a key idea that was most particularly significant for his readers: that human beings must seek perfection and the utmost happiness in theoretical life, but that utmost perfection and felicity are only possible within the virtuous city ruled by the philosopher-king. In al-Andalus, al-Muʾtaman ibn Hūd, king of Saragossa (r. 474/1081-478/1085) seems to follow these ideals. Al-Muʾtaman was a philosopher and a mathematician when he ascended the throne. Given that the scholars of his time and of the generations that followed criticised him for his religious beliefs and philosophical opinions, it may well be that he attempted to rule as a philosopher-king. This article presents, on the one hand, a study of the personal and intellectual biographies of al-Muʾtaman, and on the other, an analysis of the relationship between the rational sciences and the society that generated a king of his calibre, focusing above all on its intrinsic complexity and its roots (the intellectual legacy of Umayyad Cordova). In this way, the article provides insights into the relationship between knowledge and power and, more particularly, into the legitimising role of secular knowledge inside religiously oriented societies.
Hasan Hanafi and ‘The Indissoluble Bond’ between Heritage and Renewal
Authors: Puig Montada Josep
Published: April 2023

Hassan Hanafi, (1935-2021), graduated in 1956 from Cairo University and in October of the same year he started his doctoral studies at the Sorbonne in Paris. This was the beginning of his lifelong project on ‘Heritage and Renewal’ aiming at renewing Islam by means of reworking its legacy. This article analyses the milestones of his project, represented by an prolific intellectual production, and organized in a triangular form. The base of the triangle is the science of Koranic exegesis, and the two sides are the analysis of the Ancient Muslim heritage and that of the Western impact.
A new species of Caecilia Linnaeus, 1758 (Amphibia: Gymnophiona: Caeciliidae) from the Pacific lowlands of Colombia, with comments on the status of C. tenuissima Taylor, 1973
Authors: FERNÁNDEZ-ROLDÁN JUAN DAVID , LYNCH JOHN D.
Published: April 2023

We here describe a new species of the genus Caecilia from the Pacific lowlands of Colombia that was mistaken in previous literature as C. tenuissima, but which has more primary and secondary grooves than that species (among other differences). The description of Caecilia wilkinsoni sp. nov. restricts the known distribution of C. tenuissima to Guayaquil, Ecuador, re-establishing its status as an endemic species. We comment on the type locality of C. tenuissima, the current condition of its holotype, and on the distributions of the Caecilia that inhabit the Pacific region of Colombia.
Three new species of the genus Vappolotes Zhao & Li, 2019 (Araneae, Agelenidae) from southwest China
Authors: LI BING , ZHAO ZHE , LI SHUQIANG
Published: April 2023

Three new species of Vappolotes Zhao & Li, 2019 (Araneae: Agelenidae) are described from Hunan and Sichuan provinces, China: V. longshan sp. n. (♀♂), V. tianjiayu sp. n. (♀), and V. hei sp. n. (♀♂). The diagnostic characters of this genus are amended based on the newly obtained data. Photographs of habitus and copulatory organs, as well as their distributions, are provided for all new Vappolotes species.
A new species of Toxorhinus Lacordaire (Coleoptera: Curculionidae: Dryophthorinae; Rhynchophorini) from Ecuador
Authors: ANDERSON ROBERT S.
Published: April 2023

Toxorhinus amarillo Anderson, new species (Coleoptera: Curculionidae: Dryophthorinae; Rhynchophorini), is here described from Ecuador (Cotopaxi, Biochoa Otonga). The species is compared to the other two species in the genus.
Hierarchical maximum likelihood identification based on Levenberg–Marquardt and particle swarm optimization for feedback nonlinear systems
Authors: Zong Tiancheng , Li Junhong , Lu Guoping
Published: April 2023

This article covers the identification of the feedback nonlinear systems. The parameterized nonlinear identification model involves products of system nonlinear part parameters and system linear part parameters. To deal with these product terms, the hierarchical identification based on maximum likelihood is used to decompose the system into two subsystems. The Levenberg–Marquardt and particle swarm optimization methods are applied for identifying the two subsystems, respectively. For the purpose of enhancing the optimization capability of the basic particle swarm optimization method, some improvement strategies are constructed. Thus, the improved particle swarm optimization algorithm which combines the adaptive feedback, the linearly decreasing method and the mutational operator is applied to adaptively adjust the search strategy and improve the ergodicity. The simulation indicates that the derived estimation is effective because it can obtain high identification accuracy and fast convergence speed when identifying the feedback systems. Besides, the case study demonstrates that the proposed method can be well used to identify the electro-hydraulic-servo position system.
Outlining Individual and Contextual Factors Related to LGBTQ+ Bullying: A Systematic Review of Two Decades of Research
Authors: Espino Esperanza , Jiménez-Díaz Olga , Del Rey Rosario , Elipe Paz
Published: April 2023

Scientific interest in lesbian, gay, bisexual, transgender, queer and any other sexual orientation, gender identity and/or expression (LGBTQ+) bullying in educational settings has grown exponentially in recent years. However, the varied ways of measuring its occurrence and associated factors have made it difficult to achieve a holistic understanding of this problem. Therefore, this systematic review aimed to provide an updated overview of individual and contextual factors related to LGBTQ+ bullying over the past two decades, based on the measurement approach to this phenomenon. Studies published from 2000 to 2020 were analyzed following the Preferred Reporting Items for Systematic reviews and Meta-Analyses strategy. Inclusion and exclusion criteria were applied in a staggered process, and 111 articles met all the criteria. Studies focusing on LGBTQ+ bullying victimization or aggression were eligible for inclusion. Our analysis revealed LGBTQ+ bullying is usually examined by measures of general aggressions (47.8%) from the victims’ perspective (87.3%). The best-represented factors across studies were individual characteristics (63.1%; n = 70), especially participants’ sexual orientation and gender identity and expression (68.5%). Boys/males, from a binary gender perspective, and sexual and gender minority youth in general, were more at risk of being targeted for LGBTQ+ bullying. Although contextual factors were far less well-represented, the results revealed that gay-straight alliances, anti-homophobia policies, and social support act as protective factors. This review highlights the need to analyze LGBTQ+ bullying considering the full spectrum of sexual and gender diversity, to examine in more detail its contextual risk/protective factors, and to design public policies and psychoeducational programs in order to address the low effectiveness of generic interventions. Implications for future research and practice are discussed.
Sensing the (digital) pulse. Future steps for improving the secondary use of data for research in Switzerland
Authors: Martani Andrea , Geneviève Lester Darryl , Wangmo Tenzin , Maurer Julia , Crameri Katrin , Erard Frédéric , Spoendlin Julia , Pauli-Magnus Christiane , Pittet Valerie , Sengstag Thierry , Soldini Emiliano , Hirschel Bernard , Borisch Bettina , Kruschel Weber Cornelia , Zwahlen Marcel , Elger Bernice Simone
Published: April 2023

Introduction

Ensuring that the health data infrastructure and governance permits an efficient secondary use of data for research is a policy priority for many countries. Switzerland is no exception and many initiatives have been launched to improve its health data landscape. The country now stands at an important crossroad, debating the right way forward. We aimed to explore which specific elements of data governance can facilitate – from ethico-legal and socio-cultural perspectives – the sharing and reuse of data for research purposes in Switzerland.

Methods

A modified Delphi methodology was used to collect and structure input from a panel of experts via successive rounds of mediated interaction on the topic of health data governance in Switzerland.

Results

First, we suggested techniques to facilitate data sharing practices, especially when data are shared between researchers or from healthcare institutions to researchers. Second, we identified ways to improve the interaction between data protection law and the reuse of data for research, and the ways of implementing informed consent in this context. Third, we put forth ideas on policy changes, such as the steps necessary to improve coordination between different actors of the data landscape and to win the defensive and risk-adverse attitudes widespread when it comes to health data.

Conclusions

After having engaged with these topics, we highlighted the importance of focusing on non-technical aspects to improve the data-readiness of a country (e.g., attitudes of stakeholders involved) and of having a pro-active debate between the different institutional actors, ethico-legal experts and society at large.
The path to tuberculosis elimination: a renewed vision
Authors: Migliori Giovanni Battista , Dowdy David , Denholm Justin T. , D'Ambrosio Lia , Centis Rosella
Published: April 2023

Tuberculosis (TB) elimination and pre-elimination, with thresholds of 1 and 10 incident cases per million population, respectively, were considered achievable for low TB incidence countries in the 1990s, when they were conceived. However, it has since become clear that, even in low TB incidence settings with effective programmes and sufficient resources, achieving pre-elimination in the next decade will require a dramatic acceleration of efforts. In this review, we describe the history of the TB elimination concept and existing country experiences, as well as the interventions available to accelerate the progress towards this threshold. We then propose a framework for near-term progress towards the more aspirational goal of TB pre-elimination. This framework consists of five stages (high incidence, moderate incidence, low incidence, nearing pre-elimination and pre-elimination) that are benchmarked to specific levels of TB incidence in each country. Using this framework, countries can set 5-year targets of achieving certain reductions in TB incidence and/or reaching the next stage, through the use of strategies tailored to both local epidemiology and available organisation and infrastructure. TB elimination remains as an aspirational goal in all stages, but certain activities can be prioritised in the short term to make more rapid progress, ensure local-level buy-in and increase accountability. As TB pre-elimination is approached, certain ethical and social concerns are likely to rise in importance; these concerns are also discussed. Our aim in setting this framework is to guide clinicians, public health experts and decision makers in taking actionable next steps in the trajectory towards TB pre-elimination and elimination.
Autoantibodies are associated with disease progression in idiopathic pulmonary fibrosis
Authors: Koether Katerina , Besnard Valérie , Sandig Hilary , Carruthers Alan , Miranda Elena , Grootenboer-Mignot Sabine , Taillé Camille , Chevret Sylvie , Valeyre Dominique , Nunes Hilario , Israel-Biet Dominique , Lim Wei Keat , Cottin Vincent , Corkill Dominic , Dobson Claire , Groves Maria , Ferraro Franco , Guenzi Edouard , Huang Ling , Sulikowski Michal , Mailleux Arnaud , Murray Lynne Anne , Mustelin Thomas , Strickland Ian , Sleeman Matthew A. , Crestani Bruno
Published: April 2023

Several reports have highlighted a potential role of autoreactive B-cells and autoantibodies that correlates with increased disease severity in patients with idiopathic pulmonary fibrosis (IPF). Here we show that patients with IPF have an altered B-cell phenotype and that those subjects who have autoantibodies against the intermediate filament protein periplakin (PPL) have a significantly worse outcome in terms of progression-free survival. Using a mouse model of lung fibrosis, we demonstrate that introducing antibodies targeting the endogenous protein PPL (mimicking naturally occurring autoantibodies seen in patients) directly in the lung increases lung injury, inflammation, collagen and fibronectin expression through direct activation of follicular dendritic cells, which in turn activates and drives proliferation of fibroblasts. This fibrocyte population was also observed in fibrotic foci of patients with IPF and was increased in peripheral blood of IPF patients compared to aged-matched controls. This study reiterates the complex and heterogeneous nature of IPF, identifying new pathways that may prove suitable for therapeutic intervention.
The “vicious circle” of chronic cough: the patient experience – qualitative synthesis
Authors: Brindle Kayleigh , Morice Alyn , Carter Natalie , Sykes Dominic , Zhang Mengru , Hilton Andrea
Published: April 2023

Aim

The aim of this study was to systematically search and synthesise findings from peer-reviewed qualitative studies describing the experiences of those living with chronic cough.

Methods

A systematic search was conducted to identify all studies that used qualitative methodology to report on the experiences of adults living with chronic cough. A thematic synthesis of the first-hand narratives was undertaken. Key themes in relation to personal perspectives and experiences of living with chronic cough were identified and grouped into analytical themes.

Results

Six studies met the inclusion criteria. The thematic synthesis generated three analytical themes: 1) “It's just a cough”; 2) “Constant cough and constant worry”; and 3) “No light at the end of the tunnel”, highlighting the biopsychosocial nature of chronic cough. The synthesis highlights chronic cough as a heterogeneous experience that may appear idiosyncratic, completely consuming the lives of those living with it.

Conclusion

This is to our knowledge the first qualitative synthesis reporting on the perceptions and experiences of adults living with chronic cough. Our review draws attention to the paucity of literature that utilises qualitative methodology to explore the experience of living with chronic cough. We highlight the missing voice of people living with chronic cough in the contemporary literature. There is now a requirement for research exploring the narratives of those living with chronic cough, to gain an understanding of the condition beyond simple quantification.
Myoblast-derived exosomal Prrx2 attenuates osteoporosis via transcriptional regulation of lncRNA-MIR22HG to activate Hippo pathway
Authors: Li Yunchao , Wang Xiaoxiao , Pan Changyu , Yuan Hui , Li Xinyi , Chen Zejun , He Haoyu
Published: April 2023

Background

Sarcopenia and osteoporosis are common diseases that predominantly affect older individuals. The interaction between muscle and skeleton exerts pivotal roles in bone remodeling. This study aimed to explore the function of myoblast-derived exosomal Prrx2 in osteogenic differentiation and its potential mechanisms.

Methods

Exosomes were isolated from myogenic differentiated C2C12 cells. qRT-PCR and Western blotting were used to determine target molecule expression. Osteogenic differentiation of BMSCs was evaluated by Alizarin red staining, ALP activity and levels of OCN, OPN, RUNX2, and BMP2. Dual-luciferase reporter assay, RIP, and ChIP assays were performed to verify the interaction between molecules. The nuclear translocation of YAP1 was observed by immunofluorescence staining. In vivo osteoporotic model was established by ovariectomy in mice. Bone loss was examined using HE staining.

Results

Prrx2 expression was elevated in myogenic differentiated C2C12 cells and their exosomes. Myoblast-derived exosomal Prrx2 enhanced osteogenic differentiation of BMSCs. Delivering exosomal Prrx2 directly bond to MIR22HG promoter and promoted its transcription and expression. MIR22HG enhanced expression and nuclear translocation of YAP via sponging miR-128, thus facilitating BMSC osteogenic differentiation. Knockdown of exosomal Prrx2 suppressed osteogenic differentiation, which could be abolished by MIR22HG overexpression. Similarly, miR-128 inhibitor or YAP overexpression reversed the inhibitory effect of MIR22HG depletion or miR-128 mimics on osteogenic differentiation. Finally, myoblast-derived exosomal Prrx2 alleviated osteoporosis in mice via up-regulating MIR22HG and activating the Hippo pathway.

Conclusion

Myoblast-derived exosomal Prrx2 contributes to transcriptional activation of MIR22HG to activate YAP pathway via sponging miR-128, thereby facilitating osteogenic differentiation of BMSCs.
Current advances in nanodrug delivery systems for malaria prevention and treatment
Authors: Kekani Linda N. , Witika Bwalya A.
Published: April 2023

Malaria is a life-threatening, blood-borne disease with over two hundred million cases throughout the world and is more prevalent in Sub-Saharan Africa than anywhere else in the world. Over the years, several treatment agents have been developed for malaria; however, most of these active pharmaceutical ingredients exhibit poor aqueous solubility and low bioavailability and may result in drug-resistant parasites, thus increasing malaria cases and eventually, deaths. Factors such as these in therapeutics have led to a better appreciation of nanomaterials. The ability of nanomaterials to function as drug carriers with a high loading capacity and targeted drug delivery, good biocompatibility, and low toxicity renders them an appealing alternative to conventional therapy. Nanomaterials such as dendrimers and liposomes have been demonstrated to be capable of enhancing the efficacy of antimalarial drugs. This review discusses the recent development of nanomaterials and their benefits in drug delivery for the potential treatment of malaria.