bluuebunny/crossref_metadata_2025 huggingface dataset:
Study protocol of a randomized controlled trial for the synergizing effects of rTMS and Tui Na on upper limb motor function and cortical activity in ischemic stroke
Authors: Chen Yu-Feng , Zhu Guang-Yue , Mao Meng-Chai , Zheng Ya , Huang Hao , Liu Lan-Lan , Chen Si-Yun , Cao Ling-Yun , Xu Dong-Sheng
Published: November 2022

Upper limb motor dysfunction after stroke is a serious threat to the living quality of patients and their families. Recovery of upper limb motor function after stroke largely relies on the activation and remodeling of neural circuits. rTMS (repetitive transcranial magnetic stimulation) has been proved to promote the reconstruction of neural synapses and neural circuits. However, there are still a large number of patients who cannot fully recover and leave behind varying degrees of dysfunction. Considering the systemic pathology after stroke, in addition to focal brain injury, stroke can also cause extensive dysfunction of peripheral organs. The rehabilitation strategy for stroke should combine the treatment of primary brain lesions with the intervention of secondary systemic damage. The aim of this trial is to verify the efficacy of rTMS synergize with Tui Na (Chinese Massage) on upper limb motor function after ischemic stroke, and to explore the mechanism of activation and remodeling of sensorimotor neural circuits with functional near-infrared spectroscopy. Ninety patients will be randomly assigned to either rTMS + Tui Na + conventional rehabilitation group (the experimental group) or rTMS + conventional rehabilitation group (the control group) in 1:1 ratio. Intervention is conducted five sessions a week, with a total of twenty sessions. The primary outcome is Fugl-Meyer Assessment, and the secondary outcomes include Muscle Strength, Modified Ashworth Assessment, Modified Barthel Index Assessment, motor evoked potentials and functional near-infrared spectroscopy. There are four time points for the evaluation, including baseline, 2 weeks and 4 weeks after the start of treatment, and 4 weeks after the end of treatment. This study is a randomized controlled trial. This study was approved by Institutional Ethics Committee of Shanghai Third Rehabilitation Hospital Affiliated to Shanghai University of Traditional Chinese Medicine (approval No. SH3RH-2021-EC-012) on December, 16th, 2021. The protocol was registered with Chinese Clinical Trial Registry (ChiCTR2200056266), on February 3th, 2022. Patient recruitment was initiated on February 10th, 2022, and the study will be continued until December 2023.
Dopamine D2/3-receptor availability and its association with autonomous motivation to exercise in older adults: An exploratory [11C]-raclopride study
Authors: Simonsson Emma , Stiernman Lars Jonasson , Lundquist Anders , Rosendahl Erik , Hedlund Mattias , Lindelöf Nina , Boraxbekk Carl-Johan
Published: November 2022

Background

Autonomous motivation to exercise occurs when the activity is voluntary and with a perceived inherent satisfaction from the activity itself. It has been suggested that autonomous motivation is related to striatal dopamine D2/3-receptor (D2/3R) availability within the brain. In this study, we hypothesized that D2/3R availability in three striatal regions (nucleus accumbens, caudate nucleus, and putamen) would be positively associated with self-reported autonomous motivation to exercise. We also examined this relationship with additional exploratory analyses across a set of a priori extrastriatal regions of interest (ROI).

Methods

Our sample comprised 49 older adults (28 females) between 64 and 78 years of age. The D2/3R availability was quantified from positron emission tomography using the non-displaceable binding potential of [11C]-raclopride ligand. The exercise-related autonomous motivation was assessed with the Swedish version of the Behavioral Regulations in Exercise Questionnaire-2.

Results

No significant associations were observed between self-reported autonomous motivation to exercise and D2/3R availability within the striatum (nucleus accumbens, caudate nucleus, and putamen) using semi-partial correlations controlling for ROI volume on D2/3R availability. For exploratory analyses, positive associations were observed for the superior (r = 0.289, p = 0.023) and middle frontal gyrus (r = 0.330, p = 0.011), but not for the inferior frontal gyrus, orbitofrontal cortex, anterior cingulate cortex, or anterior insular cortex.

Conclusion

This study could not confirm the suggested link between striatal D2/3R availability and subjective autonomous motivation to exercise among older adults. The exploratory findings, however, propose that frontal brain regions may be involved in the intrinsic regulation of exercise-related behaviors, though this has to be confirmed by future studies using a more suitable ligand and objective measures of physical activity levels.
Semi-automatic segmentation of the fetal brain from magnetic resonance imaging
Authors: Wang Jianan , Nichols Emily S. , Mueller Megan E. , de Vrijer Barbra , Eagleson Roy , McKenzie Charles A. , de Ribaupierre Sandrine , Duerden Emma G.
Published: November 2022

Background

Volumetric measurements of fetal brain maturation in the third trimester of pregnancy are key predictors of developmental outcomes. Improved understanding of fetal brain development trajectories may aid in identifying and clinically managing at-risk fetuses. Currently, fetal brain structures in magnetic resonance images (MRI) are often manually segmented, which requires both time and expertise. To facilitate the targeting and measurement of brain structures in the fetus, we compared the results of five segmentation methods applied to fetal brain MRI data to gold-standard manual tracings.

Methods

Adult women with singleton pregnancies (n = 21), of whom five were scanned twice, approximately 3 weeks apart, were recruited [26 total datasets, median gestational age (GA) = 34.8, IQR = 30.9–36.6]. T2-weighted single-shot fast spin echo images of the fetal brain were acquired on 1.5T and 3T MRI scanners. Images were first combined into a single 3D anatomical volume. Next, a trained tracer manually segmented the thalamus, cerebellum, and total cerebral volumes. The manual segmentations were compared with five automatic methods of segmentation available within Advanced Normalization Tools (ANTs) and FMRIB’s Linear Image Registration Tool (FLIRT) toolboxes. The manual and automatic labels were compared using Dice similarity coefficients (DSCs). The DSC values were compared using Friedman’s test for repeated measures.

Results

Comparing cerebellum and thalamus masks against the manually segmented masks, the median DSC values for ANTs and FLIRT were 0.72 [interquartile range (IQR) = 0.6–0.8] and 0.54 (IQR = 0.4–0.6), respectively. A Friedman’s test indicated that the ANTs registration methods, primarily nonlinear methods, performed better than FLIRT (p < 0.001).

Conclusion

Deformable registration methods provided the most accurate results relative to manual segmentation. Overall, this semi-automatic subcortical segmentation method provides reliable performance to segment subcortical volumes in fetal MR images. This method reduces the costs of manual segmentation, facilitating the measurement of typical and atypical fetal brain development.
Novel weight loss diet attenuates dietary-induced obesity in mice and might correlate with altered gut microbiota and metabolite profiles
Authors: Yang Xinli , Bao Li , Zhang Ying , Long Jianglan , Li Yan , Wang Huijun , Cui Yan , Yan Dan
Published: November 2022

Although many dietary patterns have been studied for weight loss, various limitations still exist. Therefore, we designed a novel weight loss diet (NWLD) with carbohydrate, protein, and fat (energy) contents of 45%, 20%, and 35%, respectively. The saturated fatty acids: monounsaturated fatty acids:polyunsaturated fatty acids ratio was 1:2:1, and the insoluble: soluble dietary fiber ratio was 2:1. We aimed to observe the effect of NWLD on weight loss and understand the underlying metabolic mechanisms. Twenty-nine male C57BL/6J mice were selected. Nine mice were fed ordinary feed in a blank control group, and the rest were fed a high-fat diet (HFD) to establish obese mouse models. Twelve weeks later, obesity models were established, and 10 obese mice were switched to NWLD feeding. Six weeks after switching the diet, the serum, intestinal feces, and kidneys of mice were collected. Obesity-related indicators, gut microbial composition, and fecal metabolite profiles of all the mice were determined, and the correlations among these indicators were analyzed. Kidney function indicators were also assessed. The results showed that the NWLD attenuated HFD-induced weight gain, serum triglycerides (TG), and inflammatory factors, optimized the body composition without kidney function impairment. Amino acid metabolism pathways and metabolites might play key roles in this process. The findings of this research imply that NWLD could be an effective nutritional remedy for managing dietary-induced obesity.
An AI model of sonographer’s evaluation+ S-Detect + elastography + clinical information improves the preoperative identification of benign and malignant breast masses
Authors: Sun Pengfei , Feng Ying , Chen Chen , Dekker Andre , Qian Linxue , Wang Zhixiang , Guo Jun
Published: November 2022

Purpose

The purpose of the study was to build an AI model with selected preoperative clinical features to further improve the accuracy of the assessment of benign and malignant breast nodules.

Methods

Patients who underwent ultrasound, strain elastography, and S-Detect before ultrasound-guided biopsy or surgical excision were enrolled. The diagnosis model was built using a logistic regression model. The diagnostic performances of different models were evaluated and compared.

Results

A total of 179 lesions (101 benign and 78 malignant) were included. The whole dataset consisted of a training set (145 patients) and an independent test set (34 patients). The AI models constructed based on clinical features, ultrasound features, and strain elastography to predict and classify benign and malignant breast nodules had ROC AUCs of 0.87, 0.81, and 0.79 in the test set. The AUCs of the sonographer and S-Detect were 0.75 and 0.82, respectively, in the test set. The AUC of the combined AI model with the best performance was 0.89 in the test set. The combined AI model showed a better specificity of 0.92 than the other models. The sonographer’s assessment showed better sensitivity (0.97 in the test set).

Conclusion

The combined AI model could improve the preoperative identification of benign and malignant breast masses and may reduce unnecessary breast biopsies.
Diagnostic value of magnetic resonance imaging ectopic posterior pituitary hyperintense signal in pituitary macroadenoma
Authors: Luo Yi-Lin , Gu Fang , Fan Hai-Qing , Du Jin-Hui , Yu Yue , Liu Li-Kun , Liao Xin
Published: November 2022

Objective

When the lesions in the sellar region are large, they can involve both the inside and outside the sella, which brings challenges to the differential diagnosis of pituitary macroadenoma and lesions other than macroadenoma. Therefore, this study explored the diagnostic value of an ectopic posterior pituitary hyperintense signal (EPPHS) in pituitary macroadenoma and its possible causes.

Methods

The clinical and imaging data of 131 patients with sellar tumors or tumor-like lesions involving both intrasellar and extrasellar regions in the Affiliated Hospital of Guizhou Medical University from February 2011 to December 2021 were analyzed retrospectively. The diagnostic value of EPPHS in pituitary macroadenoma was analyzed. The differences in clinical and imaging indexes between the EPPHS-positive group and the EPPHS-negative group were compared.

Results

These 131 cases of sellar tumors or tumor-like lesions involving both intrasellar and extrasellar regions included 91 cases of pituitary macroadenoma and 40 cases of lesions other than macroadenoma. The receiver operator characteristic (ROC) curve analysis suggested that EPPHS had a diagnostic value in diagnosing pituitary macroadenoma [area under the curve (AUC) = 0.857, P = 0.0001]. Compared with the EPPHS negative group, the median prolactin level in the EPPHS positive group was significantly higher (P < 0.05). Through ROC curve analysis, prolactin value was found to be of diagnostic value for EPPHS (AUC = 0.612, P = 0.0312).

Conclusion

In sellar tumors or tumor-like lesions involving both intrasellar and extrasellar regions, the appearance of EPPHS is helpful in the diagnosis of pituitary macroadenoma. The formation of EPPHS may be related to injuries to the pituitary stalk.
Genotype and phenotype spectrum of 10 children with STXBP1 gene-related encephalopathy and epilepsy
Authors: Dong Meng , Zhang Tianyu , Hu Ruimei , Li Meng , Wang Guan , Liu Xinjie
Published: November 2022

Objective

STXBP1 mutations are associated with early onset epileptic encephalopathy (EOEE). Our aim was to explore the phenotype spectrum, clinical treatment and prognosis of STXBP1-related encephalopathy (STXBP1-E).

Methods

Clinical and genetic data were collected from 10 patients with STXBP1 mutations. These patients were examined and diagnosed from 2015 to 2021 at the Pediatric Department of Qilu Hospital. Blood samples were collected and sequenced by next generation sequencing and Candidate pathogenic variants were identified using Sanger sequencing in all family members.

Results

All of the patients showed severe epilepsy, varying degrees of intellectual disability and delayed motor. The patients developed multiple seizure types and abnormal electroencephalography (EEG) results at onset, and focal seizures were the most frequent seizure type. Among the patients, 2 were diagnosed with Ohtahara syndrome, 2 patient was diagnosed with West syndrome. The other 6 patients could not be diagnosed with any specifically recognized epilepsy syndrome. Five of the 10 patients had a history of fever with seizures, 4 of whom had eliminated intracranial infection according to the results of cerebrospinal fluid (CSF) examinations, and the other patient was diagnosed with anti-myelin oligodendrocyte glycoprotein (MOG) -associated encephalitis. We identified one patient with a complete deletion of STXBP1 and 9 patients with de novo heterozygous mutations of STXBP1. Among those mutations, 4 were novel (c.56°C > T, c.1315A > T, c.751G > C, and c.554_559del), and 5 had been previously reported [c.364C > T, c.569G > A (2 cases), c.748C > T, and c.1651C > T]. For 8 of our patients, different combinations of anti-seizure medications (ASMs) led to seizure freedom. One patient with MOG antibodies in his serum obtained a poor therapeutic effect from the traditional ASMs treatment, so he had to achieve seizure-free status through vagus nerve stimulation (VNS), which had little effect on his psychomotor ability. Fortunately, in one case, patient psychomotor ability was improved through VNS.

Conclusion

Our study shows that STXBP1 screening should be considered in patients with neonatal seizures with intellectual disability, and frequent seizures with fever should also be considered with the STXBP1 mutation when intracranial infection is eliminated. VNS has expanded outcome measures to include behavioral and developmental function as well as seizure control.
X-box binding protein 1: A new metabolic mediator and drug target of metformin?
Authors: Lou Kai , Sun Pei , Zhang Chunxue , Jiang Qiang , Pang Shuguang
Published: November 2022

Accumulating evidence has demonstrated that metformin improved hypertriglyceridemia. The present study aim to investigate the molecular mechanism by which metformin improves hypertriglyceridemia via regulation of diacylglycerol O-acyltransferase 2 (DGAT2) and X-box binding protein 1 (XBP1) in the liver and whether AMP-activated protein kinase (AMPK) is involved. Mice were fed a high-fat diet (HFD) or high-fat diet with metformin for 5 weeks to evaluate the effect of metformin on triglyceride (TG) levels and expression of DGAT2 and XBP1 in the liver. In vitro HepG2 cells or XBP1 knockout AML12 hepatocytes were stimulated with metformin, palmitic acid or small interfering RNA inducing XBP1 knockdown, or dominant-negative mutant AMPK plasmid. Metformin treatment reduced hepatic TG levels in the liver of HFD-fed mice. Expression of nuclear and cytoplasmic XBP1 protein and its downstream target gene DGAT2 decreased in the liver of HFD-fed mice and HepG2 cells after metformin treatment. AMPK inactivation or overexpression of XBP1 attenuates this effect. Our preliminary results demonstrate that metformin activates AMPK to reduce TG synthesis by inhibiting the XBP1-mediated DGAT2 pathway, at least in part, suggesting that XBP1 is a new metabolic mediator for metformin treatment of hypertriglyceridemia and associated metabolic disease.
Revising the application of cross-spectrum processing in motion parameter estimation for harmonic sources
Authors: Liang Ningning , Zhou Jianbo , Yang Yixin
Published: November 2022

Single-receiver motion parameter estimation is an effective and economical technology for passive source localization and train-bearing fault diagnosis, in which time-consuming time-frequency analysis (TFA) methods are widely used to suppress noise when extracting the continuous Doppler shift of the overhead pass. Cross-spectrum processing is a potential way to improve the computational efficiency of TFA methods, but its application is overshadowed by the phenomena of unknown Doppler shift offset and power spectrum estimation error. In this paper, conventional cross-spectrum processing is proven to be an approximation trick for power spectrum estimation in a small frequency interval, and the two phenomena are fully explained by the frequency aliasing of bandpass sampling and the approximation error. On this basis, an revised framework for applying the cross-spectrum processing is provided. Processing results of the SWellEx-96 experiment data demonstrate that the computational efficiencies of spectrogram and a parameterized TFA method could be improved up to 85% and 88.2%, respectively, without a noticeable impact on the accuracy of parameter estimates.
Endocrinal metabolic regulation on the skeletal system in post-menopausal women
Authors: Thapa Santosh , Nandy Ananya , Rendina-Ruedy Elizabeth
Published: November 2022

Osteoporosis is a common endocrinologic disorder characterized as a chronic bone loss condition. Sexual dimorphism is ubiquitous in the incidence of osteoporosis with post-menopausal women being acutely affected. Gonadal sex hormones including estrogen act as crucial regulators of bone mass; therefore, loss of such hormones leads to an imbalance in skeletal turnover leading to osteoporosis. Estrogen can influence both bone formation as well as resorption by reducing osteoblast activity and enhancing osteoclastogenesis. Additionally, estrogen is a potent regulator of systemic metabolism. Recent studies have provided clues that estrogenic effect on bone might also involve alterations in bone cell metabolism and bioenergetic potential. While direct effects of gonadal hormones ability to alter intracellular metabolism of bone cells has not been studied, there is precedence within the literature that this is occurring and contributing to post-menopausal bone loss. This review aims to serve as a perspective piece detailing the prospective role of gonadal hormones regulating bone cell metabolic potential.
Essential oil from Sabina chinensis leaves: A promising green control agent against Fusarium sp.
Authors: Zhang Jianyun , Zhao Ziyi , Liang Wenyu , Bi Jingyi , Zheng Yuguang , Gu Xian , Fang Huiyong
Published: November 2022

Sabina chinensis is a woody plant with important ecological functions in different regions of China, but its essential oils (EO) against plant pathogenic fungi remain largely undetermined. The purpose of our study was to assess the chemical composition and antifungal activity of S. chinensis EO based on optimization of the extraction process. In this study, an actionable and effective model with the experimental results and identified optimum conditions (crushing degree of 20 mesh, liquid–solid ratio of 10.1:1, immersion time of 9.1 h) was established successfully to achieve an extraction yield of 0.54%, which was basically consistent with the theoretical value. A total of 26 compounds were identified using headspace gas chromatography–mass spectrometry (GC–MS) and showed that the major constituent was β-phellandrene (26.64-39.26%), followed by terpinen-4-ol (6.53-11.89%), bornyl acetate (6.13-10.53%), etc. For Petri plate assays, our experiments found for the first time that S. chinensis EO revealed high and long-term antifungal activity against the tested strains, including Fusarium oxysporum and Fusarium incarnatum, at EC50 values of 1.42 and 1.15 µL/mL, which especially reached approximately 76% and 90% growth inhibition at a dose of 0.2 µL/mL, respectively. Furthermore, the antifungal activity of EO from different harvest periods showed remarkable variation. The orthogonal partial least-squares discriminant analysis (OPLS-DA) method revealed 11 metabolites with chemical marker components, and 5 of its potential antifungal activities, terpinen-4-ol, α-terpineol, α-elemol, γ-eudesmol, and bornyl acetate, were strongly correlated with the mycelial inhibition rate. In total, this study explored the antifungal activity of EO against root rot fungus as a potential fungicide and provided valuable information into developing potential products from natural agents.
Reactive oxygen species-related genes participate in resistance to cucumber green mottle mosaic virus infection regulated by boron in Nicotiana benthamiana and watermelon
Authors: Guo Huiyan , Bi Xinyue , Wang Zhiping , Jiang Dong , Cai Ming , An Mengnan , Xia Zihao , Wu Yuanhua
Published: November 2022

Cucumber green mottle mosaic virus (CGMMV) infection causes acidification and rot of watermelon flesh, resulting in serious economic losses. It is widely reported the interaction relationship between boron and reactive oxygen species (ROS) in regulating normal growth and disease resistance in plants. Our previous results demonstrated that exogenous boron could improve watermelon resistance to CGMMV infection. However, the roles of ROS-related genes regulated by boron in resistance to CGMMV infection are unclear. Here, we demonstrated that CGMMV symptoms were alleviated, and viral accumulations were decreased by boron application in Nicotiana benthamiana, indicating that boron contributed to inhibiting CGMMV infection. Meanwhile, we found that a number of differentially expressed genes (DEGs) associated with inositol biosynthesis, ethylene synthesis, Ca2+ signaling transduction and ROS scavenging system were up-regulated, while many DEGs involved in ABA catabolism, GA signal transduction and ascorbic acid metabolism were down-regulated by boron application under CGMMV infection. Additionally, we individually silenced nine ROS-related genes to explore their anti-CGMMV roles using a tobacco rattle virus (TRV) vector. The results showed that NbCat1, NbGME1, NbGGP and NbPrx Q were required for CGMMV infection, while NbGST and NbIPS played roles in resistance to CGMMV infection. The similar results were obtained in watermelon by silencing of ClCat, ClPrx or ClGST expression using a pV190 vector. This study proposed a new strategy for improving plant resistance to CGMMV infection by boron-regulated ROS pathway and provided several target genes for watermelon disease resistance breeding.
Cognitive function and brain activation before and after transcutaneous cervical vagus nerve stimulation in healthy adults: A concurrent tcVNS-fMRI study
Authors: Zhang Han , Guo Zhiwei , Qu Yun , Zhao Yu , Yang Yuxuan , Du Juan , Yang Chunlan
Published: November 2022

Transcutaneous vagus nerve stimulation, which involves the application of electrical currents to the cervical (tcVNS) or auricular (taVNS) branches of the vagus nerve, may be a potential treatment for improving cognitive dysfunction. taVNS may improve cognitive performance in healthy adults, and fewer studies have been performed on the effects of tcVNS on cognition in healthy subjects. We conducted a randomized, single-blind, crossover-controlled trial to investigate the effects of tcVNS stimulation on cognitive function and neural activity in the brains of healthy adults. This study provides support for further tcVNS studies for the treatment of cognitive impairment. Twenty-one participants were randomly divided into two groups, A and B. Group A received tcVNS first and then sham-tcVNS, while group B received the intervention in the reverse order, receiving sham stimulation first and then true stimulation. All subjects were required to perform cognitive function tests before and after receiving intervention, and functional magnetic resonance imaging (fMRI) was performed concurrently during the intervention. We hypothesized that tcVNS would have an effect on the cognitive performance of the subjects and alter the neural activity of the brain. The present study showed that tcVNS had beneficial effects on cognitive performance, mainly improving memory and language skills and attention. tcVNS intervention produced significant spontaneous neural activity in the calcarine gyrus, fusiform gyrus, lingual gyrus, and parahippocampal gyrus of the brain. Future tcVNS/fMRI trials will need to explore the effects of changes in stimulus parameters on the neural activity response of the brain.
Health behaviors of late adolescents in China: Scale development and preliminary validation
Authors: Qiu Qian , Dai Shengting , Yan Jingfei
Published: November 2022

Health behaviors influence health and well-being, improve quality of life, and provide economic benefits. It is important to take advantage of health-related opportunities during adolescence. Staying healthy during adolescence also promotes the future well-being of individuals and that of the next generation. We aimed to develop a reliable and valid scale based on the General Senior High School Physical Education and Health Curriculum Standards (2017 edition) to evaluate Chinese late adolescents’ health behavior. The scale was to help physical education teachers measure the health behavior level of senior high school students, improve physical education and health teaching, and promote Chinese adolescent health. Participants were recruited by convenience sampling from September to October 2019. For the first survey, we recruited 526 senior high school students (318 boys, 208 girls; Mage = 16.5), and the data were subjected to item analysis and exploratory factor analysis. For the second survey, we recruited 542 senior high school students (249 boys, 293 girls; Mage = 15.5), and the data were subjected to confirmatory factor analysis and internal consistency reliability analysis. After exploratory factor analysis, we extracted four factors with 23 items: exercise awareness and habits (five items), mastering and applying healthy behavior knowledge (10 items), emotional regulation (four items), and environment adaptation (four items). The Cronbach’s alpha values for these factors ranged from 0.863 to 0.937. After confirmatory factor analysis, we achieved a satisfactory goodness-of-fit model (CMIN/DF = 2.92, RMR = 0.03, GFI = 0.93, CFI = 0.91, TLI = 0.92, RMSEA = 0.06). Internal consistency, test–retest reliability, and construct validity were all satisfactory. These results suggest that the Chinese version of the Health Behavior Scale is a reliable and valid instrument for assessing the health behavior of senior high school students. The findings have important implications for increasing adolescents’ health literacy, promoting adolescents’ health, and enhancing the well-being of late adolescents.
Psychometric evaluation of the Bangla-Translated Rotter’s Internal-External Scale through classical test theory and item response theory
Authors: Siraji Mushfiqul Anwar , Haque Shamsul
Published: November 2022

There is no psychometric tool to assess locus of control for Bangla-speaking people. Hence, we attempted to translate the 23-item Rotter’s Internal-External scale into Bangla and validate it on Bangladeshi adult participants. In Study 1 (N = 300), we translated the items into Bangla and conducted an exploratory factor analysis, which gave a one-factor solution with 12 items. In Study 2, we conducted a validation study (N = 178) to accumulate evidence on the structural and concurrent validity of the 12-item scale. Structural validity assessed by confirmatory factor analysis yielded the best fit for the one-factor model with 11 items (CFI = 0.98, TLI = 0.97, RMSEA = 0.00). The scale’s significant correlations with Internal Control Index, which is also a measure of locus of control (r = −0.22,p < 0.01), Neuroticism (r = 0.21,p< 0.01) and Openness to Experience (r = −0.22,p < 0.01) demonstrated its satisfactory concurrent validity. Reliability coefficient of this 11-item scale was satisfactory (McDonald’s Omega total = 0.72). The item quality was assessed on the combined samples of Study 1 & 2 (N = 478) using the item response theory (IRT), which showed that the scale covered a sizable range of the underlying locus of control with items varying in difficulty (−1.09–2.79). Item discrimination analysis indicated sufficient discriminating power of the items (0.49–2.21). The test information curve showed the scale’s adequate ability to discriminate between external and internal locus of control. IRT analysis also indicated satisfactory marginal reliability for the scale (0.72). These psychometric properties suggest the usability of the Bangla version of Rotter’s Internal-External scale.
Middle school students’ mathematical problem-solving ability and the influencing factors in mainland China
Authors: Xu Zhuzhu , Qi Chunxia
Published: November 2022

This study investigated the mathematical problem-solving ability of 42,644 ninth-grade students who participated in regional education quality health monitoring from Z province in East China and the factors which influence their performance of mathematical problem-solving. The results are as follows: (1) ~96% of the students’ mathematics problem-solving ability meets the basic academic requirements of the mathematics curriculum standards; (2) boys and children without siblings performed better, and urban students performed significantly better than county and rural students; (3) ~28% of students’ mathematical problem-solving performance came from inter-school variability; urban and rural backgrounds had a greater impact on mathematical problem-solving than did teaching factors, while teaching self-efficacy had the least impact among the school-level influencing factors. In contrast, the influence of individual non-intelligence factors was higher than that of student background variables, including a greater positive effect of self-efficacy and a greater negative effect of mathematics anxiety.
Probing potential priming: Defining, quantifying, and testing the causal priming effect using the potential outcomes framework
Authors: Chén Oliver Y. , Phan Huy , Cao Hengyi , Qian Tianchen , Nagels Guy , de Vos Maarten
Published: November 2022

Having previously seen an item helps uncover the item another time, given a perceptual or cognitive cue. Oftentimes, however, it may be difficult to quantify or test the existence and size of a perceptual or cognitive effect, in general, and a priming effect, in particular. This is because to examine the existence of and quantify the effect, one needs to compare two outcomes: the outcome had one previously seen the item vs. the outcome had one not seen the item. But only one of the two outcomes is observable. Here, we argue that the potential outcomes framework is useful to define, quantify, and test the causal priming effect. To demonstrate its efficacy, we apply the framework to study the priming effect using data from a between-subjects study involving English word identification. In addition, we show that what has been used intuitively by experimentalists to assess the priming effect in the past has a sound mathematical foundation. Finally, we examine the links between the proposed method in studying priming and the multinomial processing tree (MPT) model, and how to extend the method to study experimental paradigms involving exclusion and inclusion instructional conditions.
Clinical EFT as an evidence-based practice for the treatment of psychological and physiological conditions: A systematic review
Authors: Church Dawson , Stapleton Peta , Vasudevan Anitha , O'Keefe Tom
Published: November 2022

Background

Since the turn of the century, Emotional Freedom Techniques (EFT) has come into widespread use in medical and psychological treatment settings. It is also used as self-help by tens of millions of people each year. Clinical EFT, the manualized form of the method, has been validated as an “evidence-based” practice using criteria published by the American Psychological Association (APA) Division 12 Task Force on Empirically Validated Therapies. Its three essential ingredients are exposure, cognitive framing, and acupressure.

Objectives

In 2013 we published a paper defining Clinical EFT and reviewing published research. It has been viewed or downloaded over 36,000 times, indicating widespread interest in this treatment modality. Here we update our findings based on subsequently published literature and propose directions for future research.

Method

We performed a systematic review of the literature to identify randomized controlled trials (RCTs) and meta-analyses. Retrieval of 4,167 results resulted in the identification of 56 RCTs (n = 2,013), 41 of which were published subsequent to our earlier review, as well as eight meta-analyses.

Results

RCTs have found EFT treatment to be effective for (a) psychological conditions such as anxiety, depression, phobias, and posttraumatic stress disorder (PTSD); (b) physiological issues such as pain, insomnia, and autoimmune conditions; (c) professional and sports performance; and (d) biological markers of stress. Meta-analyses evaluating the effect of EFT treatment have found it to be “moderate” to “large.” Successful independent replication studies have been carried out for anxiety, depression, PTSD, phobias, sports performance, and cortisol levels. We outline the next steps in EFT research. These include determining its impact on cancer, heart disease, diabetes, and cognitive impairment; analysis of the large-scale datasets made possible by mobile apps; and delivery through channels such as virtual practitioner sessions, artificial intelligence agents, online courses, apps, virtual reality platforms, and standardized group therapy.

Conclusions

Subsequent research has confirmed the conclusions of earlier studies. These find Clinical EFT to be efficacious for a range of psychological and physiological conditions. Comparatively few treatment sessions are required, treatment is effective whether delivered in person or virtually, and symptom improvements persist over time. Treatment is associated with measurable biological effects in the dimensions of gene expression, brain synchrony, hormonal synthesis, and a wide range of biomarkers. Clinical EFT is a stable and mature method with an extensive evidence base. Its use in primary care settings as a safe, rapid, reliable, and effective treatment for both psychological and medical diagnoses continues to grow.
Quality of effort in college activities and learning gains: A case study in China
Authors: Sun Chengmengxue , Liang Jingjing , Du Ruijun , Ma Jiani
Published: November 2022

This study investigated the mechanism between Chinese undergraduates’ quality of effort in college activities and learning gains, using the Chinese College Student Experiences Questionnaire (CCSEQ). 2,990 undergraduates were recruited at a case Chinese university. Gender, grade, and type of high school differences were found in Chinese undergraduates’ quality of effort in college activities and learning gains. Compared with data from American Norms, Chinese undergraduates have less interaction with teachers, lower classroom participation, and lower intellectual skills gains. Quality of effort in college activities contributed more to learning gains than demographics, with different influences based on the types of college activities. This research verifies the applicability of the CSEQ in the Chinese context and reveals the characteristics of the learning experiences of Chinese undergraduates and the underlying reasons. Recommendations for programme designers, university faculty, and undergraduates themselves were suggested.
Flow experience and city identity in the restorative environment: A conceptual model and nature-based intervention
Authors: Xie Mei , Mao Yanhui , Yang Rui
Published: November 2022

Within environmental psychology, the restorative environment is receiving increasing attention due to its favorable impact on people's mental recovery, stress reduction, and psychophysiological well-being. Flow theory, as one of the foundations of positive psychology, is a popular theoretical framework for understanding human flourishing and well-being. The restorative environment is suggested to facilitate flow experience and city identity from the perspective of positive environmental psychology. Nonetheless, systematic research investigating them all together can hardly be traced. Thus, through a preliminary review of 169 relevant studies retrieved from the data source, this work proposes a novel theoretical model in which people's interactions within the restorative environment facilitate their experience of flow and perceived city identity. Additionally, this research provides conceptual guidance for city workers to engage in nature-based intervention and leisure therapy for improved well-being. Overall, this review endeavors to contribute to developing urban workers' restoration, happiness, and well-being from both practical and theoretical perspectives.
International sport governing bodies as agents of diffusion—The case of World Athletics
Authors: Konjer Mara , Meier Henk Erik , Krieger Jörg
Published: November 2022

The current paper conceptualizes international sport governing bodies (ISGBs) as “agents of diffusion,” whose key strategic interest is in the broadest participation in their sports. Our research examines the impact of a specific diffusion strategy, adopted by World Athletics in 2008, which was essentially the decentralization of decision-making power to license athletics events, and which aimed to increase the sports' visibility and accessibility, especially in previously underdeveloped markets like Africa. We evaluate these efforts' impact by analyzing data from the season's bests lists of World Athletics from 2001 to 2019. Therefore, we employ multilevel regressions. The results are complex but instructive. We find that the efforts were of limited success especially in target regions. Still, the strategy inspired more countries to invest in both hosting new events and sending athletes to new disciplines. However, our results cast some doubt about the sustainability of these efforts. The need for a better conceptualization of relevant domestic factors becomes evident. Furthermore, we find that diffusion strategies, which do not offer material incentives, are of limited efficacy.
Top 100 most-cited articles on hemorrhoids: A bibliometric analysis and visualized study
Authors: Wang Zhaochu , Wu Xuxiong , Li Yang , Huang Juan , Shi Rong , Wang Jing
Published: November 2022

Background

Hemorrhoids have a significant incidence in people and are becoming a common public health problem. This study provides a bibliometric and visualized analysis of the most influential literature in the field. The aim is to reveal trends in the field of hemorrhoids and to provide a reference for researchers.

Methods

The 100 most frequently cited studies in the field of hemorrhoids were collected from the Web of Science(WOS), and were analyzed in terms of the annual publication, types of literature, countries, institutions, authors, journals, and keywords. During the study, we used a combination of VosViewer, Carrot2, Microsoft Excel, and Tableau tools to better present the visual information.

Results

A total of 4,481 articles were retrieved, of which 3,592 were of the Article and Review types, among which we selected the 100 most frequently cited. A large amount of highly cited literature on hemorrhoid surgery emerged from 1990 to 2010, and the interest of researchers in hemorrhoid surgery seems to have waned after 2010. The sources of highly cited literature in the field of hemorrhoids are predominantly Western, with the United States. and the United Kingdom accounting for almost half of the publications worldwide. However, countries with higher prevalence populations do not have significant research on hemorrhoids. St. Mark's Hospital has published the largest number of influential articles in the field of hemorrhoid disease. Kamm MA and Phillips RKS are the most authoritative authors in the field. Diseases of the Colon & Rectum and the British Journal of Surgery are the most influential journals in this field. The highly cited literature covers a wide range of disciplines, with Thomson's classic “The nature of hemorrhoids” receiving the most attention among the studies focusing on hemorrhoids. Keyword and clustering analysis revealed that The most famous focus in the field of hemorrhoid research is the evolution of stapled hemorrhoidectomy (SH) and Milligan-morgan hemorrhoidectomy (MMH).

Conclusions

This study is the first to explore developments in the field of hemorrhoids, and it helps surgeons quickly understand global trends in the field of hemorrhoids. In recent years, the development of hemorrhoids seems to have hit a bottleneck, with scholarly interest in the field of waning, especially in surgery Procedures. The theory of inferior anal cushion migration has proven to be the most influential theory in the field, but after studies based on SH and MMH, more high-quality evidence is needed to continue advancing the field of hemorrhoids. The results of this study are intended to add to the attention and interest of scholars in this area and provide a reference for further research.
Complete removal of intraspinal extradural mass with unilateral biportal endoscopy
Authors: Wang Tao , Yu Hang , Zhao Shi-bin , Zhu Bin , Chen Lei , Jing Jue-hua , Tian Da-sheng
Published: November 2022

Introduction

Unilateral biportal endoscopic (UBE) technique can easily decompress the bony spinal canal and accommodate all open surgical instruments under endoscopic guidance. However, indications and reports of this technique have been limited to degenerative and infectious diseases.

Methods

We used the UBE technique for the decompression and removal of extradural mass lesions in five patients. Under endoscopic guidance, a unilateral approach was used, and decompression and flavectomy were performed. After decompression, removal of the tumor was performed using various forceps. We evaluated the technical process of the procedure, the patient's pre- and postoperative symptoms, and operative radiology and pathologic results.

Results

Postoperative pain and disability improved clinically for all patients. Four patients were confirmed as having an epidural cyst and one patient was diagnosed with hemangioma. During follow-up, no recurrence was observed.

Conclusions

We successfully removed five extradural mass lesions using a biportal endoscopic posterior approach without complications. The biportal endoscopic approach may have advantages, such as minimizing trauma to the normal structures, magnified endoscopic view, and early recovery after the surgery. Biportal endoscopy may be used as an alternative surgical treatment for symptomatic intraspinal extradural benign lesions.
Consistency and Convergence Properties of 20 Recent and Old Numerical Schemes for the Diffusion Equation
Authors: Nagy Ádám , Majár János , Kovács Endre
Published: November 2022

We collected 20 explicit and stable numerical algorithms for the one-dimensional transient diffusion equation and analytically examined their consistency and convergence properties. Most of the methods used have been constructed recently and their truncation errors are given in this paper for the first time. The truncation errors contain the ratio of the time and space steps; thus, the algorithms are conditionally consistent. We performed six numerical tests to compare their performance and try to explain the observed accuracies based on the truncation errors. In one of the experiments, the diffusion coefficient is supposed to change strongly in time, where a nontrivial analytical solution containing the Kummer function was successfully reproduced.
Socioeconomic Status and Behavioral Problems in Children: The Mediating Effect of Social Relations in Mainland China
Authors: Nong Jingya , Zhu Pinghua , Li Xi , Chai Peipei , Zhai Tiemin , Zhang Yuhui
Published: November 2022

In 2014, 13.33% of youths aged 5–19 years worldwide had at least one type of behavioral problem. In China, children may be more likely to have internal and external behavioral problems, given that China has a high number of “left-behind children” and “only child of the family”. In this study, we explore the relationships between socioeconomic status (SES), social relations, and childhood behavioral problems in China. Data from 2151 children aged 10–15 years were collected from the 2018 wave of the China Family Panel Studies. We conducted structural equation modeling (SEM) using Amos (version 26) to test a theoretical model. The results showed that SES was significantly related to childhood behavioral problems, and that social relations mediated the relationship between SES and childhood behavioral problems. On the basis of these findings, we discuss relevant theoretical and practical implications.
Three-Dimensional ANP Evaluation Method Based on Spatial Position Uncertainty under RNP Operation
Authors: Dai Yuting , Lai Jizhou , Zhu Bin , Li Zhimin , Sun Xiao , Lv Pin
Published: November 2022

Performance-based navigation (PBN) operations based on the required navigation performance (RNP) operations are the trend for civil aviation in the future. In order to further ensure the safety and efficiency of civil aviation operation, RNP will transition from 2D to 3D/4D. Accurately evaluating the actual navigation performance in three-dimensional directions (3D ANP) under civil aircraft RNP operation is important to guarantee the safe flight of civil aircraft. However, the traditional two-dimensional ANP evaluation method mainly focuses on plane navigation performance along the track, lacks the evaluation of the vertical direction. Moreover, the traditional three-dimensional accuracy evaluation method is based on the assumption of three-dimensional independence and uniformity, which can only carry out approximate calculation, and the evaluation result is inaccurate. Therefore, this paper constructs a three-dimensional ellipsoid error probability (EEP) evaluation model for the spatial position uncertainty of the navigation output of the flight management system in three-dimensional directions, and gives the three-dimensional accurate ANP calculation results through iterative numerical integration. The simulation results show that the evaluation method proposed in this paper can accurately evaluate the actual navigation performance of the airborne navigation system in all directions of 3D space, and has higher evaluation accuracy and precision than the traditional ANP evaluation method, which is of great significance to ensure the flight safety of civil aircraft under 3D/4D RNP operation in the future.