bluuebunny/crossref_metadata_2025 huggingface dataset:
Rats with a missense mutation in Atm display neuroinflammation and neurodegeneration subsequent to accumulation of cytosolic DNA following unrepaired DNA damage
Authors: Quek Hazel , Luff John , Cheung KaGeen , Kozlov Sergei , Gatei Magtouf , Lee C Soon , Bellingham Mark C , Noakes Peter G , Lim Yi Chieh , Barnett Nigel L , Dingwall Steven , Wolvetang Ernst , Mashimo Tomoji , Roberts Tara L , Lavin Martin F
Published: November 2016

Mutations in the ataxia-telangiectasia (A-T)-mutated (ATM) gene give rise to the human genetic disorder A-T, characterized by immunodeficiency, cancer predisposition, and neurodegeneration. Whereas a series of animal models recapitulate much of the A-T phenotype, they fail to present with ataxia or neurodegeneration. We describe here the generation of an Atm missense mutant [amino acid change of leucine (L) to proline (P) at position 2262 (L2262P)] rat by intracytoplasmic injection (ICSI) of mutant sperm into oocytes. Atm-mutant rats (AtmL2262P/L2262P) expressed low levels of ATM protein, suggesting a destabilizing effect of the mutation, and had a significantly reduced lifespan compared with Atm+/+. Whereas these rats did not show cerebellar atrophy, they succumbed to hind-limb paralysis (45%), and the remainder developed tumors. Closer examination revealed the presence of both dsDNA and ssDNA in the cytoplasm of cells in the hippocampus, cerebellum, and spinal cord of AtmL2262P/L2262P rats. Significantly increased levels of IFN-β and IL-1β in all 3 tissues were indicative of DNA damage induction of the type 1 IFN response. This was further supported by NF-κB activation, as evidenced by p65 phosphorylation (P65) and translocation to the nucleus in the spinal cord and parahippocampus. Other evidence of neuroinflammation in the brain and spinal cord was the loss of motor neurons and the presence of increased activation of microglia. These data provide support for a proinflammatory phenotype that is manifested in the Atm mutant rat as hind-limb paralysis. This mutant represents a useful model to investigate the importance of neuroinflammation in A-T.
Identification and in silico modeling of enhancers reveals new features of the cardiac differentiation network
Authors: Seyres Denis , Ghavi-Helm Yad , Junion Guillaume , Taghli-Lamallem Ouarda , Guichard Céline , Röder Laurence , Girardot Charles , Furlong Eileen E. M. , Perrin Laurent
Published: November 2016

Developmental patterning and tissue formation are regulated through complex gene regulatory networks (GRNs) driven through the action of transcription factors (TFs) converging on enhancer elements. Here, as a point of entry to dissect the poorly defined GRN underlying cardiomyocyte differentiation, we apply an integrated approach to identify active enhancers and TFs involved in Drosophila heart development. The Drosophila heart consists of 104 cardiomyocytes, representing less than 0.5% of all cells in the embryo. By modifying BiTS-ChIP for rare cells, we examined H3K4me3 and H3K27ac chromatin landscapes to identify active promoters and enhancers specifically in cardiomyocytes. These in vivo data were complemented by a machine learning approach and extensive in vivo validation in transgenic embryos, which identified many new heart enhancers and their associated TF motifs. Our results implicate many new TFs in late stages of heart development, including Bagpipe, an Nkx3.2 ortholog, which we show is essential for differentiated heart function.
Diagnosis of dementia with Lewy bodies: can 123I-IMP and 123I-MIBG scintigraphy yield new core features?
Authors: Sakamoto Fumi , Shiraishi Shinya , Tsuda Noriko , Hashimoto Mamoru , Tomiguchi Seiji , Ikeda Manabu , Yamashita Yasuyuki
Published: November 2016

Objective:

Since the clinical symptoms of different types of dementia frequently overlap, especially in the earlier stages at onset, it is difficult to distinguish dementia with Lewy bodies (DLB) from other neurodegenerative dementias based on their clinical manifestations alone. Nuclear medicine imaging has been reported as a high-value index for the objective evaluation and diagnosis of DLB. The aim of this study was to evaluate whether nuclear medicine imaging findings may yield core features to be added to the diagnosis of DLB.

Methods:

We enrolled 332 patients with suspected DLB. All were evaluated by both 123I-metaiodobenzylguanidine (123I-MIBG) myocardial scintigraphy and 123I-labelled N-isopropyl-p-iodoamphetamine (123I-IMP). brain perfusion single-photon emission CT. The final clinical diagnosis indicated probable DLB in 92 patients (40 males, 52 females; mean age ± standard deviation, 77.4 ± 6.4 years; range, 56–89 years); 240 patients (98 males, 142 females; mean age, 75.5 ± 9.0 years; range, 70–87 years) were recorded as being without DLB. The accepted core features used for clinical evaluations were fluctuating cognition, visual hallucinations and Parkinsonism. The nuclear medicine evaluation indices were the severity score of cerebral blood flow on 123I-IMP scintigraphs of the posterior cingulate and praecuneus and a reduction in the blood flow in the occipital lobe. For 123I-MIBG evaluation, we recorded the early and delayed heart-to-mediastinum (H/M) ratios and the washout rate.

Results:

Univariate and multivariate analyses of fluctuating cognition, visual hallucinations, Parkinsonism and early H/M ratio in patients with probable and without DLB revealed significant differences. Parameters based on 123I-IMP studies did not show any significant differences by multivariate analysis. The area under the curve for the early H/M ratio was 0.918; for fluctuating cognition, visual hallucinations and Parkinsonism, it was 0.693, 0.760 and 0.611, respectively, by receiver-operating characteristic analysis. The early H/M ratio of <2.0 on 123I-MIBG scintigraphs was of the highest diagnostic accuracy. The sensitivity, specificity and accuracy for the diagnosis of probable DLB were 82.4%, 96.3% and 92.5%, respectively.

Conclusion:

The early H/M ratio obtained by 123I-MIBG myocardial scintigraphy can serve as a reliable diagnostic index for the core clinical features of DLB. It can be used for the early diagnosis and treatment of DLB.

Advances in knowledge:

123I-MIBG myocardial scintigraphy performed at the initial clinical examination can facilitate the early identification or exclusion of DLB and the early H/M ratio may be a diagnostic biomarker for DLB.
A method for evaluating the performance of computer-aided detection of pulmonary nodules in lung cancer CT screening: detection limit for nodule size and density
Authors: Kobayashi Hajime , Ohkubo Masaki , Narita Akihiro , Marasinghe Janaka C , Murao Kohei , Matsumoto Toru , Sone Shusuke , Wada Shinichi
Published: November 2016

Objective:

We propose the application of virtual nodules to evaluate the performance of computer-aided detection (CAD) of lung nodules in cancer screening using low-dose CT.

Methods:

The virtual nodules were generated based on the spatial resolution measured for a CT system used in an institution providing cancer screening and were fused into clinical lung images obtained at that institution, allowing site specificity. First, we validated virtual nodules as an alternative to artificial nodules inserted into a phantom. In addition, we compared the results of CAD analysis between the real nodules (n = 6) and the corresponding virtual nodules. Subsequently, virtual nodules of various sizes and contrasts between nodule density and background density (ΔCT) were inserted into clinical images (n = 10) and submitted for CAD analysis.

Results:

In the validation study, 46 of 48 virtual nodules had the same CAD results as artificial nodules (kappa coefficient = 0.913). Real nodules and the corresponding virtual nodules showed the same CAD results. The detection limits of the tested CAD system were determined in terms of size and density of peripheral lung nodules; we demonstrated that a nodule with a 5-mm diameter was detected when the nodule had a ΔCT > 220 HU.

Conclusion:

Virtual nodules are effective in evaluating CAD performance using site-specific scan/reconstruction conditions.

Advances in knowledge:

Virtual nodules can be an effective means of evaluating site-specific CAD performance. The methodology for guiding the detection limit for nodule size/density might be a useful evaluation strategy.
Relevance of Dialogic Approach in Ethnopsychological Theory and Practice
Authors: Соколова  , Sokolova Kristina
Published: November 2016

The article analyzes the possibility and relevance of the use of dialogical approach in ethnopsychological theory and practice. The conclusion regarding big potential of dialogic approach to learning and describing intercultural phenomenons and also to strengthening mutual understanding in intercultural interactions is made based on research of literary sources. The article substantiates importance of using dialogue for the training of specialists who can effectively act in intercultural space.
Measures of Counteraction to False Rumors: Criteria and Categories of Classification
Authors: Горбатов  , Gorbatov D. , Байчик  , Baychik A.
Published: November 2016

Classification means to combat false rumors constructed

on the following bases: tactics used for counteraction, statuses of

key communicators, objects of information influence and specifics

of its implementation, presented for the first time. The set of categories,

allowing identifying concrete means in practice, for each

classification criterion is defined. Use of this classification instead

of previous not systematized lists of measures creates prerequisites

to increase effectiveness of campaigns to combat the influence of

false rumors.
Implementation of Freedom in Religious Culture
Authors: Дмитриева  , Dmitrieva Elizaveta
Published: November 2016

The article discusses the concept of religious culture which

is based on religious dogma understood as static, unchanging foundation.

The basis for the statement of the problem is the idea of

immutability of religious culture and the realization that this type

of culture cannot be called culture in the full sense of the definition

since it is based on a static basis, namely a religious dogma. Among

the essential characteristics of culture there is freedom as a value.

How do the dogma and freedom combine within the religious

culture? Is it possible to exercise freedom within this type of culture

which is based on the religious dogma resistant to transformation?

In religious culture freedom as a three-level concept is fully realized

at the highest level of understanding freedom: despite the static,

dogmatic base of religious culture there are no restrictions on feeling

oneself free within existence, both personal and public. Religious

culture is antinomic in the connection of the highest, idealistic

appeal to God with worldly ways of its implementation which

demonstrate the specificity of this type of culture. Consideration

of the category of freedom carried out in this paper allows us to

express the specifics of implementation and realization of freedom

within religious culture, thus highlighting the cultural component

in the understanding of this type of culture. Consideration of freedom as not only philosophical but also the cultural category provides

a basis for further analysis of the main cultural components such

as the value and creativity.
Russian View of American Architecture in the Late 19th and Early 20th Centuries
Authors: Брумфилд  , Brumfield W.C.
Published: November 2016

Technology American urban construction at the turn of 19th–20th centuries caused great interest of specialists all over the world. Urban infrastructure development required a different approach to city development. All this prompted the Russian architects to study the information on technical innovations in Western Europe and the United States. The article deals with the study of the "American style" in architecture Russian architects of the late 19th and early 20th centuries.
Wine Analytics: Fine Wine Pricing and Selection Under Weather and Market Uncertainty
Authors: Hekimoğlu Mert Hakan , Kazaz Burak , Webster Scott
Published: November 2016

We examine a risk-averse distributor’s decision in selecting between bottled wine and wine futures under weather and market uncertainty. At the beginning of every summer, a fine wine distributor has to choose between purchasing bottled wine made from the harvest collected two years ago and wine futures of wine still aging in the barrel from the previous year’s harvest. At the end of the summer, after seeing weather and market fluctuations, the distributor can adjust its allocation by trading futures and bottles. This paper makes three contributions. First, we develop an analytical model to determine the optimal selection of bottled wine and wine futures under weather and market uncertainty. Our model is built on an empirical foundation in which the functional forms describing the evolution of futures and bottle prices are derived from comprehensive data associated with the most influential Bordeaux winemakers. Second, we develop structural properties of optimal decisions. We show that a wine distributor should always invest in wine futures because it increases the expected profit in spite of being a riskier asset than bottled wine. We characterize the influence of variation in various uncertainties in the problem. Third, our study empirically demonstrates for a large distributor the financial benefits of using our model. The hypothetical average profit improvement in our numerical analysis is significant, exceeding 21%, and its value becomes higher under risk aversion. The analysis is beneficial for fine wine distributors, as it provides insights into how to improve their selection in order to make financially healthier allocations.
The effects of malnutrition in hospital
Authors: Wallace Edward
Published: November 2016

Between 30 and 50% of inpatients suffer some degree of malnutrition and as a result have a higher risk of complications and higher mortality than well-nourished patients. Nurses have a fundamental role in combating and preventing malnutrition, yet lack knowledge and understanding of the problem. This article describes the effects of malnutrition and discusses the nurse's role in the provision of nutritional care.
Using reflection and experience in nurse education
Authors: Coutts-Jarman Jacqui
Published: November 2016

It has long been recognized that a gap exists between theory and practice in nursing and that the theory learned in the classroom is not seen by students to relate to their area of practice. How can nurse educators narrow this theory-practice gap? This article examines the use of reflection to facilitate cancer nurse education.
An induction programme for recovery ward nurses
Authors: Hudson Brian
Published: November 2016

Recovery ward nurses have often been viewed as the poor relations of theatre nurses. However, these nurses need the skills to care for highly dependent patients who have undergone both surgical and anaesthetic procedures. This article describes training for recovery ward nurses at the author's hospital.
Nursing people with learning disabilities: new directions
Authors: Sines David
Published: November 2016

Since the suggestion that the mental handicap branch of nursing be disbanded 21 years ago, these nurses have refocused their vision and emerged as a new and exciting specialism. This article relates their experiences to the key issues now confronting nursing in general, in a changing social and political context.
The use of aqueous cream to relieve pruritus in patients with liver disease
Authors: Ronayne Christina , Bray Gary , Robertson Gill
Published: November 2016

Pruritus in patients with liver disease is often uncontrollable; however, washing daily with aqueous cream instead of soap has been found to significantly reduce the degree of itching. It also causes no side effects.
Should nurses tell tales?
Authors: Castledine George
Published: November 2016

A hospital trust is seriously considering compulsory testing all its staff for HIV and repeating the process every 3 months. It believes the cost would be outweighed by the image it would attract as the only AIDS-free trust.
Evaluation in practice
Authors: McMahon Ann , Smith Karen
Published: November 2016

If the benefits of professional nursing are to be effectively articulated, the process of evaluation in practice must be fully exploited. Nurses in the Mid-Staffordshire General Hospitals have developed methods to help them evaluate their practice. In this article the principles underpinning these developments are described.
Task-oriented hospital workers threaten the role of nurses
Authors: English Ian , Lindsay Grace M
Published: November 2016

This article considers the precedent set by the appointment of task-oriented workers in health care, and proposes that this cost-effective strategy will compromise the quality of patient care and threaten the role of the nurse.
Is quality assurance just a theoretical pedestal?
Authors: Fox Jane
Published: November 2016

Sceptics might claim that quality assurance has become the battle cry of the late 1980s and ‘90s. Certainly, the concept of quality assurance is at the forefront of any current professional debate. Its prominence is perhaps not surprising when viewed in the context of health provision based on market economy and its related consumerism. The notion of quality in health care can only be applauded; difficulties and dissents arise only when the practicalities of defining and determining quality have to be addressed.
Prevention and management of pressure sores
Authors: Jackson Sue , McMahon Ann , Cage Rosemary
Published: November 2016

Care study

William, an 83-year old man, was admitted via the accident and emergency (A&E) department to an orthopaedic ward within the Mid-Staffordshire General Hospitals. The A&E nurse accompanying him said that he preferred to be called Bill. The reason for his admission was a fall at home, in which he had sustained a fractured neck of right femur which had been confirmed by X-ray. He had suffered pain while in the A&E department for which he was given Omnopon 20 mg. Stemetil 12.5 mg was given to counteract the nausea that is a potential side effect of Omnopon. On admission to the ward at 23.40, Bill was pain free. He was accompanied by a care assistant from the nursing home where he was currently residing.
Nurses must adapt to changes in hospital psychiatric care
Authors: Thomas Ben
Published: November 2016

Inpatient psychiatric care is changing. Users of mental health services are overwhelmingly in support of hospital closure (Rogers et al, 1993). Many professionals agree that the inpatient approach to care is outmoded and inappropriate for people with acute mental health problems. For example, Murphy (1991) suggested that the majority of people with acute mental disorder can be treated at home if sufficient staff are available to provide adequate support and supervise medication.
Who deserves care?
Authors: Dimond Bridgit
Published: November 2016

One of the most important principles of the NHS when it was established in 1948 was that treatment was to be provided to all people in need, free at the point of contact. This universal health support was part of the Beveridge package, the vast majority of benefits and services being financed through a state insurance system and a safety net of national assistance for those who were not covered by insurance.
Introducing high quality infection control in a hospital setting
Authors: Horton Rozila
Published: November 2016

Hospital infection is a quality issue and as such has become an important topic in the current health care debate. Quality assurance and resource management are becoming integral to the measurement of nursing standards in clinical practice. Quality assurance is, in many ways, inseparable from effective infection control. This article outlines the development of such a high profile demonstration unit named Quality Infection Control (QIC) and discusses its strengths and weaknesses.
Preoperative ophthalmic procedures: ritualistic or necessary?
Authors: Wells Helen
Published: November 2016

Routine ophthalmic nursing tasks are often seen as unnecessary, degrading the skill of the ophthalmic nurse in assessing, planning and implementing the care of the patient. Many ophthalmic departments have discontinued such tasks, but the reasoning and the consequences do not appear to have been documented.
Visual impairment among older people
Authors: Kelly John S
Published: November 2016

Visual impairment is the most age-related disability, with older people forming the majority of the visually disabled population. This article re-examines the nature of visual impairment among older people and points to a key role for nurses in identification and intervention.
Peritoneal dialysis: prescription for the 90s
Authors: Martin John
Published: November 2016

Over the past decade, continuous ambulatory peritoneal dialysis (CAPD) has been seen as the first-line treatment for patients requiring renal replacement therapy. This article reviews the types of peritoneal dialysis available and describes the advantages of CAPD over haemodialysis.
Use of humour and laughter in patient care
Authors: Mallett Jane
Published: November 2016

Research into humour and laughter has indicated that these have psychological, social and physical effects which may have useful applications for patient care. Humour and laughter are potentially useful therapeutic tools but, as yet, little clinical research into their utilization or efficacy has been conducted in the UK.
Skill mix does not work
Authors: Sheehan Antony
Published: November 2016

The official version of what is meant by the skill mix approach to nursing is that it is a review of the make-up of the workforce to elicit the best range of skills, utilizing differing grades, to meet a variety of patient needs. In other words, it is about finding the cheapest alternative possible. Skill mix is about cost-effectiveness, nothing more, nothing less — and no amount of political rhetoric will change that.
Management of patients with altered body image
Authors: Cronan Lisa
Published: November 2016

Nurses are well placed to help patients come to terms with altered body image. However, in order to do so they must discard some of the prejudices that they hold.
Developing a model for theatre nursing
Authors: McGee Paula
Published: November 2016

There has been much debate about the nature of theatre work and whether the activities performed by theatre nurses represent real nursing. This article examines the potential for constructing a nursing model to depict the variety of environments in which theatre nurse's work.
Child sexual abuse 1: definitions, incidence and consequences
Authors: Gillespie Francis
Published: November 2016

It is estimated that over 6600 children under the age of 16 years are sexually abused each year in England and Wales (NSPCC, 1990). Of these incidents, 78% involve female children and 22% male children. The effects on the child range from self-mutilating behaviour and dissociative disorders to suicide. Consequently, nurses caring for victims of sexual abuse need to be aware of the trauma involved.
Patient-controlled analgesia
Authors: Dening Fenella
Published: November 2016

Patient-controlled analgesia is an effective method of controlling postoperative pain, providing its introduction is planned carefully and both staff and patients have been fully trained in the technique.
Social perception and the nurse educator
Authors: Norton Elizabeth Anne
Published: November 2016

This article illustrates how psychological theory may be applied to nurse education. Nurse educators need to be aware of the impact of social perception, i.e. perception of others and perception of self, if they are to be objective and effective in teaching and assessing student nurses.
Preoperative information: the role of the ward nurse
Authors: Radcliffe Sharon
Published: November 2016

Many health care professionals are becoming increasingly aware of the benefits of giving preoperative information to patients. However, many nurses still view the provision of such information as a luxury, only to be afforded when all the ‘proper’ work is done.
Quality of life after intensive care
Authors: Rustom Rashne , Daly Kath
Published: November 2016

Assessing the quality of life of long-term survivors of intensive care is of paramount importance when attempting to justify the enormous costs of treating critically ill patients.
Do the benefits of continuing education outweigh the costs?
Authors: Nolan Mike , Grant Gordon , Melhuish Edward , Maguire Brian
Published: November 2016

Debate on the costs and benefits of continuing professional education for nurses has intensified following the PREPP proposals. Evidence suggests that nurses who consider that their educational needs are being fully met have higher morale and work more efficiently than those who do not.
In remembrance of nursing pioneers: Tiffany, Wells and Jones
Authors: Castledine George
Published: November 2016

The recent deaths of three nursing pioneers have prompted me to dedicate this column to them.
Principles of PREP
Authors: Castledine George
Published: November 2016

At long last the United Kingdom Central Council for Nurses, Midwives and Health Visitors (UKCC) has agreed its Post Registration Education and Practice (PREP) proposals (UKCC, 1993) and we now await the Government's decision. Although no date has been set for implementation, the clear message is that all registered nurses, midwives and health visitors will need to study the report as soon as they can and as carefully as possible. There are three very clear messages for us all in the future:

We can't stand still and expect to get by without further education and regular updating; We can't drop in and out of nursing without considering what we are doing or what re-education we will require; We need to think carefully about our stage and level of preparation for generalist, specialist or advanced practice.
Lifting techniques for nurse-aiders
Authors: Watson Jane
Published: November 2016

When giving first aid, nurse-aiders must assess the working environment and make it safe or either remove the patient from it. If movement is necessary, nurses must keep in mind their own bodily capability.
Stoma care nurses fight back
Authors: Groves Tina
Published: November 2016

Castledine has challenged stoma care nurses to provide evidence that they are ‘teaching other health care professionals what stoma care is all about’ and that ‘they are open to jealous criticism particularly from those who feel they can do the job just as well’. (‘Are stoma care nurses just bag handlers?’ Vol 2 (2), p. 137). Clearly this invitation and these unsubstantiated comments cannot go undefended. Many general nurses, as well as stoma care nurses, have been angered by the opinion that ‘stoma care nurses are just bag handlers’.
Use of therapeutic humour by psychiatric nurses
Authors: Dunn Barbara
Published: November 2016

Humour is an essential part of our everyday communication. While for the nurse, there are differences between social and clinical environments, humour cannot be turned on or off in either. Consciously attempting to avoid humour leads to stunted, rigid interaction.
Characteristic of immune response of hepatitis B immunization on infants with two different schedules
Authors: Muhammad Edy , Carmelia Rita , Yuliati Yuliati , Lubis Iskandar Z. , Manoeroeng S. M.
Published: November 2016

Hepatitis B immunization gives protection to hepatitis B disease. The purpose of this study was to assess the immune response of hepatitis B immunization on infants with 0,2,9 and 3,4,9 months of age schedule. The study was performed cross sectionally at the Child Health clinic of Social Pediatric sub division H. Adam Malik Hospital from November 1st 1998 until February 28th 1999. The anti HBs responses were examined in blood by ELISA method one month after the third immunization at the Clinical Pathology Division FK-USU/H. Adam Malik Hospital. Protective immune response defined if the anti HBs level ³ 10 mIU/ml. Nutritional status of infants were grouped according to the NCHS classification. The result obtained were statistically tested by Fisher exact test and t-test, on the level of significance p < 0.05. Twenty six (86.7%) of the infants had protective immune response and there were no significant difference on the level of immune response among these two groups. Gender and nutritional status seems to have no influence on the anti HBs level. In Conclusion, hepatitis B immunization either with 0,2,9 or 3,4,9 months of age schedule obtained the same immune response.
The role of ACE inhibitor in reducing persistent proteinuria in nephrotic syndrome
Authors: Hutabarat Erika , Alatas Husein , Hadinegoro Sri Rezeki
Published: November 2016

Background Patients with persistent proteinuria are at risk for progression to end-stage renal failure. Angiotensin converting enzyme inhibitor (ACEI) can decrease proteinuria in nephrotic syndrome (NS) patients with persistent proteinuria.Objective To evaluate the effectiveness of ACEI (enalapril) in reducing proteinuria in NS.Methods This study was conducted as a randomized double blind clinical trial with crossover design on persistent proteinuria NS patients who visited Cipto Mangunkusumo Hospital from December 2000 until July 2001. Twenty patients were enrolled in this study. Ten patients received enalapril 10 mg/day for 8 weeks and ten patients received placebo. Angiotensin converting enzyme inhibitor as considered effective if proteinuria was reduced for at least 50%.Results The patients aged between 2-16 years with a mean of 11.3 years and consisted of 16 boys and 4 girls with a ratio of 4:1. Urine protein and creatinine ratio (Up/Uc) was used to evaluate proteinuria. In the ACEI group, the mean value of proteinuria increasedtrom5.6 (95%CI 1.1 ;2.2)to 6.7 (95%CI 0.3;13.2) (p=0.721),  although it decreased in five patients. Decreased proteinuria to 50%or more was found in 2 out of 10 patients in the enalapril group while in the placebo group it was found in 3 out of 10, but this differences was not statistically significant (,0=0.5). Systolic blood pressure decreased significantly (p=0.0185) from 107 mmHg (95%CI 101.1;112.9 mmHg) to 103 mmHg (95%CI 96.2;109.8 mmHg) although still in nonnal range.Conclusions The efficacy of enalapril in reducing proteinuria could not be evaluated yet. A further study with greater sample and longer observation is needed.
The risk of urinary tract infection in children with nephrotic syndrome
Authors: Gunawan Patricia Y. , Umboh Adrian
Published: November 2016

Background Urinary tract infections (UTI) may affect any part of the urinary system: the kidneys, ureters, bladder, or urethra. Nephrotic syndrome (NS) is the most common glomerular disorder in childhood, comprising a group of symptoms that include proteinuria, hypoalbuminemia, hypercholesterolemia, and edema. The prevalence of UTI in NS patients is high, around 25-66.7%. The increased prevalence of UTI in NS is due to immunoglobulin loss, defective T cell function, the presence of ascites, and relative malnutrition.Objective To study the risk of UTI in children with NS.Methods We performed a retrospective study of NS and UTI patients from January 2004 to December 2013 in the Division of Nephrology at Prof. Dr. R.D. Kandou Hospital, Manado. Data was collected from medical records. Diagnosis of UTI was made based on urine culture results. Diagnosis of NS was made based on the group of symptoms mentioned above. Analysis was done using Chi-square test with SPSS version 22 software.Results Of 74 NS patients, 34 (46%) had UTIs. During the same study period, 117 patients had UTIs. NS was more common in boys (64.9%), while NS with UTI was more common in girls (67.6%). The most common organisms causing UTI in NS patients were Eschericia coli and Citrobacter diversus (23% each). Imipenem and amikacin were most commonly used antibiotics to which the bacteria were sensitive. Increased risk of UTI was significant in children with NS (OR 1.8; P=0.03).Conclusion Children with NS are at significantly increased risk of UTIs.
The relationship between thrombocytopenia and intraventricular hemorrhage in neonates with gestational age <35 weeks
Authors: Yulandari Idha , Rundjan Lily , Kadim Muzal , Amalia Pustika , Wulandari Haryanti F. , Handryastuti Setyo
Published: November 2016

Background The prevalence of thrombocytopenia in neonates ranges from 22 to 35%, and one of the most feared complica­tions is intraventricular hemorrhage (IVH). Previous research in Cipto Mangunkusumo Hospital (CMH), Jakarta reported a high incidence of IVH (43.47%) in infants with a gestational age of <35 weeks. Intraventricular hemorrhage causes disturbances in neurological development and can be fatal. In Indonesia, re­search on the relationship between thrombocytopenia and IVH has been limited.Objective To study the relationship between thrombocytopenia and IVH in neonates with gestational age <35 weeks and assess for a correlation between the severity of thrombocytopenia and the severity of IVH.Methods This cross-sectional study was performed by reviewing medical records in the Neonatology Division of the Child Health Department, University of Indonesia, CMH. Subjects were neonates hospitalized from January 2012 to December 2014 with IVH. Subjects were categorized into either mild to moderate IVH (grade ≤2) or severe IVH (grade >2). Thrombocyte counts were recorded on the same day as the diagnosis of IVH.Results The risk of severe IVH was 28.2% in neonates with thrombocyte counts <100,000/uL, and 10.4% in neonates without thrombocytopenia (P=0.014). Multivariate analysis revealed that gestational age <32 weeks and the use of respira­tory support (ventilator and high frequency oscillatory ventila­tion) had significant associations with severe IVH. However, multivariate analysis did not show a significant relationship between thrombocytopenia and severe IVH (correlation coef­ficient = 0.21).Conclusion Thrombocytopenia is not significantly associated with the incidence of severe IVH based on multivariate analysis. Also, the severity of thrombocytopenia has no correlation with the severity of IVH.
Fault diagnostics of DC motor using acoustic signals and MSAF-RATIO30-EXPANDED
Authors: Glowacz Adam
Published: November 2016

An early fault diagnostic method of Direct Current motors was presented in this article. The proposed method used acoustic signals of a motor. A method of feature extraction called MSAF-RATIO30-EXPANDED (method of selection of amplitudes of frequencies - ratio 30% of maximum of amplitude - expanded) was presented and implemented. An analysis of proposed method was carried out for early fault states of a real DC motor. Four following states of the DC motor were measured and analyzed: the healthy DC motor, DC motor with 3 shorted rotor coils, DC motor with 6 shorted rotor coils, DC motor with a broken coil. Measured states were caused by natural degradation of the DC motor. The obtained results of analysis were good. The presented early fault diagnostic method can be used for protection of DC motors.
Model of the double-rotor induction motor in terms of electromagnetic differential
Authors: Adamczyk Dominik , Wilk Andrzej , Michna Michal
Published: November 2016

The paper presents a concept, a construction, a circuit model and experimental results of the double-rotor induction motor. This type of a motor is to be implemented in the concept of the electromagnetic differential. At the same time it should fulfill the function of differential mechanism and the vehicle drive. One of the motor shafts is coupled to the direction changing mechanical transmission. The windings of the external rotor are powered by slip rings and brushes. The inner rotor has the squirrel-cage windings. The circuit model parameters were calculated based on the 7.5 kW real single-rotor induction motor (2p = 4). Experimental verification of the model was based on comparison between the mentioned single-rotor motor and double-rotor model with the outer rotor blocked. The presented results showed relatively good compliance between the model and real motor.
Nonlinear behavior analysis of split-winding dry-type transformer using a new star model and a coupled field-circuit approach
Authors: Azizian Davood
Published: November 2016

Regarding the importance of short circuit and inrush current simulations in the split-winding transformer, a novel nonlinear equivalent circuit is introduced in this paper for nonlinear simulation of this transformer. The equivalent circuit is extended using the nonlinear inductances. Employing a numerical method, leakage and magnetizing inductances in the split-winding transformer are extracted and the nonlinear model inductances are estimated using these inductances. The introduced model is validated and using this nonlinear model, inrush and short-circuit currents are calculated. It has been seen that the introduced model is valid and suitable for simulations of the split-winding transformer due to various loading conditions. Finally, the effects of nonlinearity of the model inductances are discussed in the following.
The impact of speed as well as selected parameters of slot insulation on the distribution of temperature in linear motion converters
Authors: Mikołajewicz Jacek
Published: November 2016

This paper presents and discusses the mathematical model of thermal phenomena occurring in axis-symmetric electromechanical linear motion converters. On the basis of the developed model, software to analyze the process of the heating up of this type of converters, was created. The effect of the thickness and type of material of the slot insulation, as well as the speed of the runner on the temperature distribution in the analyzed object was examined in-depth. Selected results of simulated calculations have been presented.
Simple utilization of lactic acid whey in dairy processing
Authors: Csanádi J. , Szász G. , H-Bara O.
Published: November 2016

The use of ultra-filtered lactic acid whey retentate was investigated for the making of sour cream. The utilization of lactic acid whey is limited due to its special properties, so the logical utilization way is to use it in fermented products. First, we concentrated lactic acid whey collected from cottage cheese making by ultrafiltration (UF), then UF Whey Retentate (UFWR) was added (by 2, 5, and 10%) into fat standardized cream for sour cream making. We investigated the texture and sensory properties of the sour cream samples compared with the industrial products. Generally, we can state that the use of small portion of UF whey retentate did not result noticeable changes and did not reduce the sensory value of sour creams. Higher UF whey retentate addition improved some texture properties of experimental samples, but the summarized evaluation of UFWR addition was not unequivocal. Control samples showed better results. Based on our results, the sample, which contained 5% UF whey retentate, had good texture and acceptable sensory properties. Furthermore, more than 5% UF lactic acid whey retentate (coming from our own ultrafiltration process) resulted remarkably worse sensory properties than the other samples. Further investigation is needed to find the optimal composition and sensory properties of UFWR. Furthermore, we have to perform technological investigation to reach a higher concentration factor using pre-treatment of whey and to avoid the precipitation of whey proteins during the high temperature pasteurization of cream, cream mixed with UFWR or diafiltered whey retentate. We guess that the use of one-stage diafiltration would already decrease the unfavourable sensory properties of lactic acid whey retentate.
Flour quality and kernel hardness connection in winter wheat
Authors: Szabó B. P. , Gyimes E. , Véha A. , Horváth Zs. H.
Published: November 2016

Kernel hardness is controlled by friabilin protein and it depends on the relation between protein matrix and starch granules. Friabilin is present in high concentration in soft grain varieties and in low concentration in hard grain varieties. The high gluten, hard wheat our generally contains about 12.0–13.0% crude protein under Mid-European conditions. The relationship between wheat protein content and kernel texture is usually positive and kernel texture influences the power consumption during milling. Hard-textured wheat grains require more grinding energy than soft-textured grains.

The aim of our research was to determine the possible relationship between kernel hardness and various other parameters of the our (dough visco-elastic characteristics, wet gluten, water absorption, our recovery, alveograph). We used Perten SKCS 4100 to determine the kernel hardness, while the Perten 3303 mill was used to establish Particle Size Index (PSI). Registered and widely used Hungarian wheat varieties (7 of HRWW and 4 of SRWW) were applied in the study. Twin correlations were used to determine the relationship among the various traits.

According to the results, there is a very strong correlation between milling energy and kernel hardness (r = 0:99): The correlation between hardness index and the examined our parameters was also significant (r = 0:81–0:87). We found strong correlation between the milling energy and water absorption (r = 0:88) of our. The associations found in this study will help the better understanding of the technological aspects concerning wheat grain and our quality.
Alternative grains in nutrition
Authors: Jevcsák Sz. , Sipos P.
Published: November 2016

Many people suffer from gluten sensitivity or gluten intolerance. They have to avoid or limit their gluten intake. Sorghum and millet are gluten-free cereals, wherefore persons with gluten sensitivity or gluten intolerance could consume them. Moreover, they have a lot of positive effects due to their phenolic compounds as phenol acid or flavonoid. Antioxidant activity in sorghum is especially high in comparison with other cereals. Our aim was to compare literature data about the chemical compositions of sorghum and millet with other grains.
Acting on Magic and Winning with Words in Märchen Worlds (and Beyond)
Authors: Lindahl Carl
Published: November 2016

Folk narrative scholarship valorizes the selfhood of us, the observers, at the expense of the narrating communities. We scholars celebrate our own subjectivity, in spite of the fact that the traditional narrators whose art we study elevate the concerns of their communities over their personal concerns. Because all attempts to deny the observer's subjectivity will fail, the only way we can bring the study of folk narrative into closer harmony with the values of the narrating communities is to
Der Autor als Gespenst:Anverwandlung von Straparolas Märchen in der deutschen Literatur des Barock
Authors: Messerli Luisa Rubini
Published: November 2016

Der Beitrag befasst sich mit dem 1684 in Leipzig erschienenen Roman
Mobile Devices and Social Networks within Pre-Service Teacher Preparation
Authors: Burgerová Jana , Adamkovičová Martina
Published: November 2016

The article provides results of monitoring the ownership and exploitation of mobile devices and social networks within the pre-service teacher preparation at the Faculty of Education, University of Presov in Presov, Slovak Republic. The research sample consisted of 473 respondents by the method of questionnaire. The tool was available online and included 12 items requiring both open and multiple choice answers of one, four or more choices. The data were processed by the IBM SPSS statistics software. The results are displayed in the form of figures and described. They proved students were equipped with various types of both the latest and other devices. They exploit them to access to study materials, information reflecting their personal and professional interests. Within the research the use of social networks was also under the focus. The results showed three types of social networks (Facebook, LinkedIn and Google+) are the most frequently accessed, both for university and further education.
Inquiry Based Education of Selected Informatics Topics – Analysis and Results
Authors: Šnajder Ľubomír , Guniš Ján
Published: November 2016

In the paper we present the partial results of a qualitative research achieved in the project Innovation efficiency methods of teaching mathematics, physics and informatics (VEMIV). The project is aimed at developing inquiry skills of pupils and conceptual comprehension of the subject matter. In the first part we describe basic characteristics of inquiry-based education. In the second part we present two methodologies of teaching informatics. The first methodology is primarily focused on scientific research methods viable in school informatics. In the second one, we focus primarily on the content of school informatics. The methodologies were implemented and commented by teachers from partner grammar schools. At the end of both methodologies we summarize and analyze the results of inquiry-based education according to the presented methodologies. Our findings are supported by the results of pupils’ works, the results of concepTest and evaluation feedback from teachers. In conclusion, we present recommendations for the implementation and evaluation of inquirybased informatics education.
Obesity and Knee Arthroscopy – a Review
Authors: Tilinca Mariana , Pop Tudor Sorin , Bățagă Tiberiu , Zazgyva Ancuța , Niculescu Marius
Published: November 2016

Obesity is currently a global epidemic, often referred to as “globesity”, impacting the life of millions worldwide. A risk factor for many diseases, obesity can also be linked to developing intra-articular lesions of the knee, affecting the menisci, ligaments and cartilage. Furthermore, obesity has been shown to influence the outcome of surgical interventions, including those of the musculoskeletal system. Although many studies addressed the relationship of obesity and joint replacement, articles relating to arthroscopy and obesity, and knee arthroscopy in particular, are a bit scarcer. The majority of data suggest that an increase in BMI leads to a similar increase in the rates of intra- and postoperative complications, and most authors agree that a higher body mass index can influence both the procedure itself and its outcomes, including the subjective results reported by the patients. Still, some studies show different results, especially in patients that are overweight or with low-grade obesity, where the outcomes are comparable to those of the non-obese population. Thus, it can be concluded that obesity is an important patient characteristic that needs to be taken into consideration when planning, performing, and assessing the results of knee arthroscopy.