bluuebunny/crossref_metadata_2025 huggingface dataset:
Evaluation of Synovial Calprotectin by Using a Lateral Flow Test for the Diagnosis of Prosthetic Joint Infections
Authors: Bottagisio Marta , Viganò Marco , Pellegrini Antonio , Logoluso Nicola , Zagra Luigi , Prina Andrea , de Girolamo Laura , De Vecchi Elena
Published: February 2023

The analysis of synovial fluid is a crucial step in the diagnosis of prosthetic joint infections (PJIs). Recently several studies illustrated the efficacy of synovial calprotectin in supporting the diagnosis of PJI. In this study, synovial calprotectin was analyzed by a commercial stool test to explore whether it might accurately predict PJIs. The synovial fluids of 55 patients were analyzed and calprotectin levels were compared to other synovial biomarkers of PJI. Of the 55 synovial flu-ids, 12 patients were diagnosed with PJI and 43 with an aseptic failure of the implant. Specificity, sensitivity, and AUC of calprotectin resulted in 0.944, 0.80, and 0.852 (95%CI: 0.971–1.00), respectively, with a set threshold of 529.5 µg/g. Calprotectin had a statistically relevant correlation with the synovial leucocyte counts (rs = 0.69, p < 0.001) and the percentage of synovial neutrophils (rs = 0.61, p < 0.001). From this analysis, it can be concluded that synovial calprotectin is a valuable biomarker that correlates with other established indicators of local infection, and the use of a commercial lateral flow stool test could be a cost-effective strategy delivering rapid and reliable results and supporting the diagnostic process of PJI.
Implementation of Telerehabilitation in an Early Supported Discharge Stroke Rehabilitation Program before and during COVID-19: An Exploration of Influencing Factors
Authors: Auger Louis-Pierre , Moreau Emmanuelle , Côté Odile , Guerrera Rosalba , Rochette Annie , Kairy Dahlia
Published: February 2023

Objective: To identify the factors influencing the implementation of telerehabilitation (TR) in a post-stroke early supported discharge (ESD) rehabilitation program as perceived by clinicians and managers. Methods: A descriptive qualitative design was used in collaboration with a Canadian ESD stroke rehabilitation program. After 15 months of pre-COVID-19 implementation and 4 months of COVID-19 implementation, 9 stakeholders (7 clinicians, 1 coordinator and 1 manager) from an ESD program participated in 2 focus groups online or an individual interview. Qualitative data were coded and analyzed semi-deductively for the pre-COVID-19 and COVID-19 phases using the Consolidated Framework for Implementation Research (CFIR). Results: Four categories emerged related to the CFIR, each with themes: (1) Telerehabilitation, which included “Technology” and “Clinical activities”; (2) Telerehabilitation users, which included: “Clients’ characteristics” and “Clinicians’ characteristics”; (3) Society and healthcare system, which included “Changes related to COVID-19” and “ESD program”; and (4) TR implementation process, which included “Planning” and “Factors that influenced practice change”. Conclusions: Factors impacting TR implementation in the ESD program were found to be numerous and varied according to the pre-COVID-19 or COVID-19 phases. Clinicians’ motivation regarding potential gains for them in using TR was key in its implementation during the COVID-19 period.
Modified Heuristic Computational Techniques for the Resource Optimization in Cognitive Radio Networks (CRNs)
Authors: Bilal Ahmad , Latif Shahzad , Ghauri Sajjad A. , Song Oh-Young , Abbasi Aaqif Afzaal , Karamat Tehmina
Published: February 2023

With the advancement of internet technologies and multimedia applications, the spectrum scarcity problem is becoming more acute. Thus, spectral-efficient schemes with minimal interference for IoT networks are required. Device-to-device communication (D2D) technology has the potential to solve the issue of spectrum scarcity in future wireless networks. Additionally, throughput is considered a non-convex and NP-hard problem, and heuristic approaches are effective in these scenarios. This paper presents two novel heuristic approaches for throughput optimization for D2D users with quality of service (QoS)-aware wireless communication for mobile users (MU): the modified whale colony optimization algorithm (MWOA) and modified non-domination sorted genetic algorithm (MNSGA). The performance of the proposed algorithms is analyzed to show that the proposed mode selection technique efficiently fulfills the QoS requirements. Simulation results show the performance of the proposed heuristic algorithms compared to other understudied approaches.
Virtual Training System for the Teaching-Learning Process in the Area of Industrial Robotics
Authors: Ipiales Jordan S. , Araque Edison J. , Andaluz Víctor H. , Naranjo César A.
Published: February 2023

This paper focuses on the development of a virtual training system by applying simulation techniques such as: Full Simulation and Hardware-in-the-Loop (HIL). This virtual reality system is intended to be a teaching and learning tool focused on the area of industrial robotics. For this purpose, mathematical models (kinematic and dynamic) have been considered. These models determine the characteristics and restrictions of the movements of a Scara SR-800 robot. The robot is then virtualized to simulate position and trajectory tasks within virtual environments. The Unity 3D graphic engine (Unity Software Inc., San Francisco, CA, USA), allows the design and development of the training system which is composed of a laboratory environment and an industrial environment. The same that contribute to the visualization and evaluation of the movements of the robot through the proposed control algorithm using the mathematical software (MatLab, manufactured by MathWorks, USA), through shared memories. This software in turn can be linked to an electronic board (Raspberry Pi) for data acquisition through a wireless connection. Finally, the stability and robustness of the implemented controllers are analyzed, as well as the correct operation of the virtual training system.
Effects of Image Size on Deep Learning
Authors: Rukundo Olivier
Published: February 2023

In this work, the best size for late gadolinium enhancement (LGE) magnetic resonance imaging (MRI) images in the training dataset was determined to optimize deep learning training outcomes. Non-extra pixel and extra pixel interpolation algorithms were used to determine the new size of the LGE-MRI images. A novel strategy was introduced to handle interpolation masks and remove extra class labels in interpolated ground truth (GT) segmentation masks. The expectation maximization, weighted intensity, a priori information (EWA) algorithm was used for the quantification of myocardial infarction (MI) in automatically segmented LGE-MRI images. Arbitrary threshold, comparison of the sums, and sums of differences are methods used to estimate the relationship between semi-automatic or manual and fully automated quantification of myocardial infarction (MI) results. The relationship between semi-automatic and fully automated quantification of MI results was found to be closer in the case of bigger LGE MRI images (55.5% closer to manual results) than in the case of smaller LGE MRI images (22.2% closer to manual results).
An HBase-Based Optimization Model for Distributed Medical Data Storage and Retrieval
Authors: Zhu Chengzhang , Liu Zixi , Zou Beiji , Xiao Yalong , Zeng Meng , Wang Han , Fan Ziang
Published: February 2023

In medical services, the amount of data generated by medical devices is increasing explosively, and access to medical data is also put forward with higher requirements. Although HBase-based medical data storage solutions exist, they cannot meet the needs of fast locating and diversified access to medical data. In order to improve the retrieval speed, the recognition model S-TCR and the dynamic management algorithm SL-TCR, based on the behavior characteristics of access, were proposed to identify the frequently accessed hot data and dynamically manage the data storage medium as to maximize the system access performance. In order to improve the search performance of keys, an optimized secondary index strategy was proposed to reduce I/O overhead and optimize the search performance of non-primary key indexes. Comparative experiments were conducted on real medical data sets. The experimental results show that the optimized retrieval model can meet the needs of hot data access and diversified medical data retrieval.
Study on Gas–Solid Two–Phase Flow Characteristics of One–Furnace with Two–Tower Semi–Dry Desulfurization in Circulating Fluidized Bed Boiler
Authors: Wang Xueshen , Gan Zheng , Xin Shengwei , Yang Chunzhen
Published: February 2023

A single–phase flow model was used to analyze the uniformity of the flow field in the desulfurization tower under different baffle combinations, and a multiphase flow model was used to explain the gas and solid two–phase flow characteristics and chemical reaction characteristics in the tower. The stability of the flow behavior of gas and solids in one furnace and two towers was discussed. The results show that the installation of shielding plates at appropriate positions in the tower for sulfur removal is beneficial to enhance the uniform distribution of flow in space, reduce the pulsation interference of bed pressure in the tower, keep the state of gas and solid flow unchanged, and maintain the efficiency of desulfurization at a high level. Reducing the instability of gas–solid two–phase flow is the basis of ensuring the stable switching between single and double towers.
Effect of Xylanase-Assisted Treatment of Oxygen-Delignified Eucalypt Kraft Pulp on ECF Bleaching
Authors: Matos José M. S. , Evtuguin Dmitry V. , Sousa António P. M. , Carvalho Maria Graça V. S.
Published: February 2023

The effects of treating industrial (laboratory-unwashed) oxygen-delignified eucalypt kraft pulp with a commercial endo-xylanase (X) on ECF bleaching performance were evaluated. Changes in fibre morphology, pulp bleachability and quality, and bleaching effluent parameters were assessed. Although no significant morphological changes were observed, fibres showed some external fibrillation. The X stage reduced both the amount and the integrity of xylans remaining in the fibres, causing their redistribution inside the cell wall. In bleaching, the X treatment allowed the reduction of ClO2 and NaOH loads by 20 and 10%, respectively. Furthermore, the brightness stability of enzyme-treated bleached pulps was improved, which was assigned to the decrease in the content of hexenuronic acid residues. The X treatment did not affect the cellulosic counterpart of pulp and did not cause a significant impact on the papermaking properties, even when xylan degradation was somewhat excessive. The enzymatic treatment caused a significant increase in the chemical oxygen demand (COD) of the respective effluent. The realistic conditions used provide a better insight into the overall impact of this technology at a pulp mill.
Non-Structural Carbohydrates and Growth Adaptation Strategies of Quercus mongolica Fisch. ex Ledeb. Seedlings under Drought Stress
Authors: Wang Yu , Han Xiaoyi , Ai Wanfeng , Zhan Hao , Ma Sujuan , Lu Xiujun
Published: February 2023

Under drought stress, plants can change their morphology, physiological characteristics, and carbon allocation to maintain survival and growth. Non-structural carbohydrates (NSC) are major substrates for plant metabolism and play an important role in seedling survival and growth under drought conditions. Mongolian oak (Quercus mongolica Fisch. ex Ledeb.), a constructive species distributed in northeast China, has a high drought tolerance. However, studies on seedling growth and the NSC dynamics of Mongolian oak under different drought intensities and durations are limited. To investigate this, our study measured photosynthetic characteristics, growth, biomass, and NSC concentrations for Mongolian oak seedlings on the 0, 15th, 30th, 45th, and 60th day of the experiment under three soil moisture conditions [75% ± 5% (CK), 50% ± 5% (W1), and 23% ± 5% (W2) of soil moisture field capacity (FC)]. Results showed that the growth and biomass gradually decreased as the soil moisture decreased, but the root: shoot ratio and root biomass allocation ratio gradually increased. In the W1 treatment (moderate drought), NSC content in the stems and taproots was 7.42% and 16.39% higher than those in CK at 60 days. However, in W2 treatment (severe drought), NSC content in the stems and taproots was significantly higher than those in CK during the whole period (p < 0.05), and they were 14.14% and 26.69% higher than those in CK at 60 days. We found that, under drought stress, Mongolian oak seedlings had lower growth but higher allocation to root biomass and higher NSC content in stems and roots. Furthermore, the root system became a vital carbon sink under drought stress and was beneficial for seedling survival.
Cellulosic Fiber Waste Feedstock for Bioethanol Production via Bioreactor-Dependent Fermentation
Authors: Mansy Ahmed E. , El-Desouky Eman , El-Gendi Hamada , Abu-Saied Mohamed A. , Taha Tarek H. , Amer Ranya A.
Published: February 2023

The bioconversion of environmental wastes into energy is gaining much interest in most developing and developed countries. The current study is concerned with the proper exploitation of some industrial wastes. Cellulosic fiber waste was selected as a raw material for producing bioethanol as an alternative energy source. A combination of physical, chemical, and enzymatic hydrolysis treatments was applied to maximize the concentration of glucose that could be fermented with yeast into bioethanol. The results showed that the maximum production of 13.9 mg/mL of glucose was achieved when 5% cellulosic fiber waste was treated with 40% HCl, autoclaved, and followed with enzymatic hydrolysis. Using SEM and FTIR analysis, the instrumental characterization of the waste fiber treatment confirmed the effectiveness of the degradation by turning the long threads of the fibers into small pieces, in addition to the appearance of new functional groups and peak shifting. A potent yeast strain isolated from rotten grapes was identified as Starmerella bacillaris STDF-G4 (accession number OP872748), which was used to ferment the obtained glucose units into bioethanol under optimized conditions. The maximum production of 3.16 mg/mL of bioethanol was recorded when 7% of the yeast strain was anaerobically incubated at 30 °C in a broth culture with the pH adjusted to 5. The optimized conditions were scaled up from flasks to a fermentation bioreactor to maximize the bioethanol concentration. The obtained data showed the ability of the yeast strain to produce 4.13 mg/mL of bioethanol after the first 6 h of incubation and double the amount after 36 h of incubation to reach 8.6 mg/mL, indicating the efficiency of the bioreactor in reducing the time and significantly increasing the product.
Fire Danger Assessment Using Moderate-Spatial Resolution Satellite Data
Authors: Kussul Nataliia , Fedorov Oleh , Yailymov Bohdan , Pidgorodetska Liudmyla , Kolos Liudmyla , Yailymova Hanna , Shelestov Andrii
Published: February 2023

Fire is one of the most common disturbances in natural ecosystems. The analysis of various sources of information (official and unofficial) about the fires in Ukraine (2019–2020) showed a lack of timely and reliable information. Satellite observation is of crucial importance to provide accurate, reliable, and timely information. This paper aims to modify the index of fire danger of a forest’s FWI by increasing its precision, based on the use of higher spatial resolution satellite data. A modification of the FWI method involves the utilization of the soil moisture deficit, in addition to the six subindices of the FWI system. In order to calculate the subindices values, weather data from the Copernicus Atmosphere Monitoring Service were used. Soil moisture deficit is calculated using Sentinel-1 radar satellite data on the water saturation degree of the soil surface layer and geospatial parameters from the 3D Soil Hydraulic Database of Europe. The application of the proposed methodology using the specified satellite, weather, and geospatial data makes it possible to assess fire danger on a continental scale with a spatial resolution of 250 m, 1 km, and a daily temporal resolution. Validation of the proposed method for modifying the FWI system demonstrates an improvement in the precision and relevance of fire danger prediction.
Au Nanoparticles Functionalized Covalent-Organic-Framework-Based Electrochemical Sensor for Sensitive Detection of Ractopamine
Authors: Yang Shuying , Yang Ruixi , He Jingyi , Zhang Yu , Yuan Yahong , Yue Tianli , Sheng Qinglin
Published: February 2023

Ractopamine, as a feed additive, has attracted much attention due to its excessive use, leading to the damage of the human nervous system and physiological function. Therefore, it is of great practical significance to establish a rapid and effective method for the detection of ractopamine in food. Electrochemical sensors served as a promising technique for efficiently sensing food contaminants due to their low cost, sensitive response and simple operation. In this study, an electrochemical sensor for ractopamine detection based on Au nanoparticles functionalized covalent organic frameworks (AuNPs@COFs) was constructed. The AuNPs@COF nanocomposite was synthesized by in situ reduction and was characterized by FTIR spectroscopy, transmission electron microscope and electrochemical methods. The electrochemical sensing performance of AuNPs@COF-modified glassy carbon electrode for ractopamine was investigated using the electrochemical method. The proposed sensor exhibited excellent sensing abilities towards ractopamine and was used for the detection of ractopamine in meat samples. The results showed that this method has high sensitivity and good reliability for the detection of ractopamine. The linear range was 1.2–1600 μmol/L, and the limit of detection (LOD) was 0.12 μmol/L. It is expected that the proposed AuNPs@COF nanocomposites hold great promise for food safety sensing and should be extended for application in other related fields.
A Dual-Signaling Electrochemical Aptasensor Based on an In-Plane Gold Nanoparticles–Black Phosphorus Heterostructure for the Sensitive Detection of Patulin
Authors: Xu Jinqiong , Liu Jianbo , Li Wuwu , Wei Yongsheng , Sheng Qinglin , Shang Yonghui
Published: February 2023

Patulin (PAT), a type of mycotoxin existing in foodstuffs, is harmful to food safety and human health. Thus, it is necessary to develop sensitive, selective and reliable analytical methods for PAT detection. In this study, a sensitive aptasensor based on a dual-signaling strategy was fabricated, in which a methylene-blue-labeled aptamer and ferrocene monocarboxylic acid in the electrolyte acted as a dual signal, for monitoring PAT. To improve the sensitivity of the aptasensor, an in-plane gold nanoparticles–black phosphorus heterostructure (AuNPs-BPNS) was synthesized for signal amplification. Due to the combination of AuNPs-BPNS nanocomposites and the dual-signaling strategy, the proposed aptasensor has a good analytical performance for PAT detection with the broad linear range of 0.1 nM–100.0 μM and the low detection limit of 0.043 nM. Moreover, the aptasensor was successfully employed for real sample detection, such as apple, pear and tomato. It is expected that BPNS-based nanomaterials hold great promise for developing novel aptasensors and may provide a sensing platform for food safety monitoring.
Bioactive Compounds Extracted from Saudi Dates Using Green Methods and Utilization of These Extracts in Functional Yogurt
Authors: Ghafoor Kashif , Sarker Md. Zaidul Islam , Al-Juhaimi Fahad Y. , Mohamed Ahmed Isam A. , Babiker Elfadil E. , Alkaltham Mohammed S. , Almubarak Abdullah K.
Published: February 2023

The bioactive compounds of four Saudi date flesh extracts (Ambara (AF), Majdool (MF), Sagai (SF), and Sukkari (SKF)) prepared using different extraction methods—namely, supercritical fluid extraction (SFE), subcritical CO2 extraction (SCE), and Soxhlet extraction (SXE)—were evaluated. A total of 19 bioactive compounds were detected in extracts prepared using SFE and SCE methods, whereas less than 12 compounds were detected in extracts obtained using the SXE method. Both the date variety and extraction method affected the phenolic profile of date flesh extract (p ≤ 0.05). The apparent viscosity, surface color, and bioactive properties of yogurt were affected by both date flesh extracts and storage duration in varied magnitudes (p ≤ 0.05). The incorporation of date flesh extracts into yogurt formulations increased the total phenolic content (TPC), DPPH antiradical activity, viscosity, and redness (a*) and decreased the lightness (L*) and yellowness (b*) of the developed product (p ≤ 0.05). The elongation of storage time progressively (p ≤ 0.05) reduced the pH, TPC, DPPH antiradical activity, bacterial counts, and L* and b* values and increased the acidity, syneresis, viscosity, and a* values with few exceptions. Date flesh extracts can improve the health quality of yogurt without major influence on the sensory attributes while stored at 4 °C.
Observational Imprints of Enhanced Scalar Power on Small Scales in Ultra Slow Roll Inflation and Associated Non-Gaussianities
Authors: Ragavendra H. V. , Sriramkumar L.
Published: February 2023

The discovery of gravitational waves from merging binary black holes has generated considerable interest in examining whether these black holes could have a primordial origin. If a significant number of black holes have to be produced in the early universe, the primordial scalar power spectrum should have an enhanced amplitude on small scales, when compared to the COBE normalized values on the large scales that is strongly constrained by the anisotropies in the cosmic microwave background. In the inflationary scenario driven by a single, canonical scalar field, such power spectra can be achieved in models that permit a brief period of ultra slow roll inflation during which the first slow roll parameter decreases exponentially. In this review, we shall consider a handful of such inflationary models as well as a reconstructed scenario and examine the extent of formation of primordial black holes and the generation of secondary gravitational waves in these cases. We shall also discuss the strength and shape of the scalar bispectrum and the associated non-Gaussianity parameter that arise in such situations. We shall conclude with an outlook wherein we discuss the wider implications of the increased strengths of the non-Gaussianities on smaller scales.
Primordial Black Hole Formation in Non-Standard Post-Inflationary Epochs
Authors: Bhattacharya Sukannya
Published: February 2023

When large overdensities gravitationally collapse in the early universe, they lead to primordial black holes (PBH). Depending on the exact model of inflation leading to necessary large perturbations at scales much smaller than scales probed at the Cosmic Microwave Background (CMB) surveys, PBHs of masses ≲103M⊙ are formed sometime between the end of inflation and nucleosynthesis. However, the lack of a direct probe for the exact expansion history of the universe in this duration introduces uncertainties in the PBH formation process. The presence of alternate cosmological evolution for some duration after inflation affects the relation between (i) PBH mass and the scale of the collapsing overdensity; and (ii) PBH abundance and amplitude of the overdensities. In this review, the non-standard cosmological epochs relevant for a difference in PBH production are motivated and discussed. The importance of developing the framework of PBH formation in non-standard epochs is discussed from a phenomenological point of view, with particular emphasis on the advances in gravitational wave (GW) phenomenology, since abundant PBHs are always accompanied by large induced GWs. PBH formation in general non-standard epochs is also reviewed including the mathematical formalism. Specific examples, such as PBH formation in a kinetic energy dominated epoch and an early matter dominated epoch, are discussed with figures showing higher PBH abundances as compared to the production in standard radiation domination.
Unexpected Findings in Hereditary Breast and Ovarian Cancer Syndrome: Low-Level Constitutional Mosaicism in BRCA2
Authors: Hidalgo Mayoral Irene , Almeida Santiago Ainhoa , Sánchez-Zapardiel Jose Manuel , Hidalgo Calero Beatriz , de la Hoya Miguel , Gómez-Sanz Alicia , de Miguel Reyes Montserrat , Robles Luis
Published: February 2023

Hereditary breast and ovarian cancer syndrome (HBOC) is a clinical entity characterized by an increased risk of developing breast and ovarian cancer. The genetic diagnosis is based on the identification of heterozygous germinal variants in HBOC susceptibility genes. However, it has recently been described that constitutional mosaic variants can contribute to the aetiology of HBOC. In constitutional mosaicism, individuals have at least two genotypically distinct populations of cells that arise from an early post-zygote event. The mutational event occurs early enough in development to affect several tissues. It is detected in germinal genetic studies as low variant allele frequency (VAF) variants (<30%) that are generally overlooked during the prioritization process. Constitutional mosaic variants can affect both somatic and germinal cells, and thus can be passed to the offspring and have important consequences for genetic counselling. In this work, we report the c.9648+1G>A mosaic variant in the BRCA2 gene and propose a diagnostic algorithm to deal with potential mosaic findings identified by Next Generation Sequencing (NGS).
Candidate Genes and Gene Networks Change with Age in Japanese Black Cattle by Blood Transcriptome Analysis
Authors: Chang Chencheng , Yang Yanda , Zhou Le , Baiyin Batu , Liu Zaixia , Guo Lili , Ma Fengying , Wang Jie , Chai Yuan , Shi Caixia , Zhang Wenguang
Published: February 2023

Age is an important physiological factor that affects the metabolism and immune function of beef cattle. While there have been many studies using the blood transcriptome to study the effects of age on gene expression, few have been reported on beef cattle. To this end, we used the blood transcriptomes of Japanese black cattle at different ages as the study subjects and screened 1055, 345, and 1058 differential expressed genes (DEGs) in the calf vs. adult, adult vs. old, and calf vs. old comparison groups, respectively. The weighted co-expression network consisted of 1731 genes. Finally, blue, brown, and yellow age-specific modules were obtained, in which genes were enriched in signaling pathways related to growth and development and immune metabolic dysfunction, respectively. Protein-protein interaction (PPI) analysis showed gene interactions in each specific module, and 20 of the highest connectivity genes were chosen as potential hub genes. Finally, we identified 495, 244, and 1007 genes by exon-wide selection signature (EWSS) analysis of different comparison groups. Combining the results of hub genes, we found that VWF, PARVB, PRKCA, and TGFB1I1 could be used as candidate genes for growth and development stages of beef cattle. CORO2B and SDK1 could be used as candidate marker genes associated with aging. In conclusion, by comparing the blood transcriptome of calves, adult cattle, and old cattle, the candidate genes related to immunity and metabolism affected by age were identified, and the gene co-expression network of different age stages was constructed. It provides a data basis for exploring the growth, development, and aging of beef cattle.
Evaluation and Management of Pediatric Feeding Disorder
Authors: Dharmaraj Rajmohan , Elmaoued Rasha , Alkhouri Razan , Vohra Pankaj , Castillo Ricardo O.
Published: February 2023

Feeding disorders are increasingly common in children, especially as medical advancements improve the life expectancy of children born with prematurity and complex medical conditions. The most common symptoms include malnutrition, refusal to eat and drink, food pocketing, disruptive feeding behavior, slow feeding, food selectivity or rigid food preferences, limited appetite, and delayed feeding milestones. A unifying diagnostic definition of pediatric feeding disorder has been proposed by a panel of experts to improve the quality of health care and advance research. Referral to specialized care should be considered when feeding problems are complex or difficult to resolve. In this review, we provide an overview of the evaluation and management of pediatric feeding disorders and information that may be useful when considering whether referral to specialized care may be beneficial.
Stocking Practices of Anti-Tuberculosis Medications among Community Pharmacists and Patent Proprietary Medicine Vendors in Two States in Nigeria
Authors: Adepoju Victor Abiola , Adelekan Ademola , Oladimeji Olanrewaju
Published: February 2023

Background: Evidence has shown that non-fixed-dose combination (non-FDC) anti-TB drugs could promote the spread of drug-resistant tuberculosis (DR-TB). We aimed to determine anti-TB medication stocking and dispensing practices among patent medicine vendors (PMVs) and community pharmacists (CPs) and their determinants. Method: This was a cross-sectional study using a structured, self-administered questionnaire among 405 retail outlets (322 PMVs and 83 CPs) across 16 Lagos and Kebbi local government areas (LGAs) between June 2020 and December 2020. Data were analyzed with Statistical Program for Social Sciences (SPSS) for Windows version 17 (IBM Corp., Armonk, NY, USA). Chi-square test and binary logistic regression were used to assess the determinants of anti-TB medication stocking practices at a p-value of 0.05 or less for statistical significance. Results: Overall, 91%, 71%, 49%, 43% and 35% of the respondents reported stocking loose rifampicin, streptomycin, pyrazinamide, isoniazid and ethambutol tablets, respectively. From bivariate analysis, it was observed that being aware of directly observed therapy short course (DOTS) facilities (OR 0.48, CI 0.25–0.89, p < 0.019) and having previous training on TB (OR 0.32, CI 0.14–0.73, p < 0.005) reduced the odds of stocking anti-TB medication, while operating more than 1 shop (OR 3.32, CI 1.44–7.57, p = 0.004), having 3 or more apprentices (OR 5.31, CI 2.74–10.29, p < 0.001) and seeing over 20 clients/day (OR 3.02, CI 1.18–7.71, p = 0.017) increased the odds of stocking loose anti-TB medications. From multivariate analysis, it was observed that only the variable having three or more apprentices (OR 10.23, CI 0.10–0.49, p = 0.001) significantly increased the odds of stocking anti-TB medications. Conclusions: The stocking of non-FDC anti-TB medications was high and largely determined by the number of apprentices among PMVs and CPs in Nigeria, and this may have serious implications for drug resistance development. However, the results linking the stocking of anti-TB to the number of apprentices should be interpreted cautiously as this study did not control for the level of sales in the pharmacies. We recommend that all capacity-building and regulatory efforts for PMVs and CPs in Nigeria should include not just the owners of retail premises but also their apprentices.
Linked Argumentation Graphs for Multidisciplinary Decision Support
Authors: Xiao Liang , Greer Des
Published: February 2023

Multidisciplinary clinical decision-making has become increasingly important for complex diseases, such as cancers, as medicine has become very specialized. Multiagent systems (MASs) provide a suitable framework to support multidisciplinary decisions. In the past years, a number of agent-oriented approaches have been developed on the basis of argumentation models. However, very limited work has focused, thus far, on systematic support for argumentation in communication among multiple agents spanning various decision sites and holding varying beliefs. There is a need for an appropriate argumentation scheme and identification of recurring styles or patterns of multiagent argument linking to enable versatile multidisciplinary decision applications. We propose, in this paper, a method of linked argumentation graphs and three types of patterns corresponding to scenarios of agents changing the minds of others (argumentation) and their own (belief revision): the collaboration pattern, the negotiation pattern, and the persuasion pattern. This approach is demonstrated using a case study of breast cancer and lifelong recommendations, as the survival rates of diagnosed cancer patients are rising and comorbidity is the norm.
The Use of a Hybrid Closed-Loop System for Glycemic Control in Two Pediatric Patients with Type 1 Diabetes Undergoing Minor Surgery
Authors: Seget Sebastian , Włodarczyk Julia , Lutogniewska Wanda , Rusak Ewa , Dróżdż Maria , Jarosz-Chobot Przemysława
Published: February 2023

Technological progress in the treatment of type 1 diabetes requires doctors to use modern methods of insulin therapy in all areas of medicine that patients may come into contact with, including surgical interventions. The current guidelines indicate the possibility of using continuous subcutaneous insulin infusion in minor surgical procedures, but there are few reported cases of using a hybrid closed-loop system in perioperative insulin therapy. This case presentation focuses on two children with type 1 diabetes who were treated with an advanced hybrid closed-loop (AHCL) system during a minor surgical procedure. In the periprocedural period, the recommended mean glycemia and the time in range were maintained.
Impact of Geriatric Admissions on Workload in the Emergency Department
Authors: Kłosiewicz Tomasz , Rozmarynowska Monika , Konieczka Patryk , Mazur Mateusz
Published: February 2023

Background: Due to the increase in life expectancy, both the general population and the population of patients of emergency departments (ED) are getting older. An understanding of differences, workload and resource requirements may be helpful in improving patient care. The main goal of this study was to evaluate the reasons for geriatric admissions in the ED, identify typical medical problems and assess the number of resources in order to provide more effective management. Methods: We examined 35,720 elderly patients’ ED visits over the course of 3 years. The data collected included age, sex, timing and length of stay (LOS), use of various resources, endpoint (admission, discharge or death) and ICD-10 diagnoses. Results: The median age was 73 years [66–81], with more females (54.86%). There were 57.66% elderly (G1), 36.44% senile (G2) and 5.89% long-liver (G3) patients. There were more females in the older groups. The total admission rate was 37.89% (34.19% for G1, 42.21% for G2 and 47.33% for G3). The average length of the patient’s stay was 150 min [81–245] (G3 180 min [108–277], G2 (162 min [92–261]) and G1 139 min [71–230]). Heart failure, atrial fibrillation and hip fracture were the most common diagnoses. Nonspecific diagnoses were common in all groups. Conclusion: The vast majority of geriatric patients required considerable resources. With increasing ages, the number of women, LOS and number of admissions increased.
Life on Board Portuguese Ships in the 16th–18th Centuries: Theorizing Households through History and Archaeology
Authors: Casimiro Tânia Manuel , Borges Marco Oliveira
Published: February 2023

Recognizing and defining behaviors is among the most challenging objectives of writing narratives about the past, especially when direct testimony and the evidence of agents’ actions are long lost. Typically, archaeologists look at material remains to reconstruct daily activities, while historians read and interpret documents that articulate how agents interacted with their surroundings. Following an interdisciplinary approach combining archaeology and history, the purpose of this paper is to reconstruct how different types of agents co-existed on board Portuguese ships in the Early Modern Age, and how those relations can be interpreted as a household. These ships sailed across different oceans with different purposes and destinations, carrying people, animals, and things, all of which had a level of agency. All these agents led to the development of specific relations and ways of being, characterizing the particular dynamics and associations during voyages.
Archaeometric Characterisation and Assessment of Conservation State of Coins: The Case-Study of a Selection of Antoniniani from the Hoard of Cumae (Campania Region, Southern Italy)
Authors: Pagano Sabrina , Balassone Giuseppina , Germinario Chiara , Grifa Celestino , Izzo Francesco , Mercurio Mariano , Munzi Priscilla , Pappalardo Lucia , Spagnoli Emanuela , Verde Maria , De Bonis Alberto
Published: February 2023

The paper presents the first archaeometric results on a selection of ancient Roman coins (antoniniani) from a treasure found in the Roman necropolis area of ancient Cumae (Southern Italy) during archaeological campaigns by the Centre Jean Bérard. A multi-analytical approach consisting of non-destructive techniques (stereomicroscopy, FESEM-EDS, pXRF, Raman, μ-CT) was implemented on the better-preserved coins of the treasure in order to investigate the chemical composition of the alloy. Chemical analysis showed that the Roman mint prepared the metal with an argentiferous lead–bronze alloy. A group of coins presents a low content of the precious metal, which is in agreement with the financial crisis of the Roman Empire of the third century. Another group of two coins shows a higher silver content, which is in agreement with their issue or with the Mediolanum mint standards. In addition, the external layers of corroded coins were analysed to explore the state of conservation of the patina and to identify the corrosion products. Some typical corrosion patinas due to post-depositional conditions were identified. The mineralogical characterisation of the corrosion products enables us to implement adequate conservation strategies, and the presence of more aggressive patinas suggests immediate interventions.
Exogenous Application of Melatonin Alleviates Drought Stress in Ranunculus asiaticus by Improving Its Morphophysiological and Biochemical Attributes
Authors: Eisa Eman Abdelhakim , Honfi Péter , Tilly-Mándy Andrea , Gururani Mayank Anand
Published: February 2023

Melatonin (MT) controls various physiological functions and enhances plant drought tolerance. This study aimed to evaluate the effect of exogenous MT on the morpho-physiological and biochemical attributes of Ranunculus asiaticus under normal and drought conditions. A completely randomized design was used with two factors, drought stress and MT concentration (0, 50, 100, and 200 μM), to assess the effect of foliar application of MT on R. asiaticus seedlings. The experiment was conducted with a total of two groups: the drought stress group and the control group. The foliar application of MT was carried out four times during the study period. The drought stress group exhibited considerably decreased shoot length by 26.0%, leaf number by 31.03%, leaf area by 62.2%, fresh and dry vegetative weights by 34.5% and 52.9%, respectively, total chlorophyll and carotenoid contents by 68.29% and 51.72%, respectively, and relative water content by 7.1%; early emergence of flower stalks was observed within 29 days; increased relative electrolyte leakage by 20.5% compared to well-watered plants. Conversely, the foliar application of MT notably increased growth parameters compared with their no-treatment counterparts. Foliar treatment with 200 µM MT resulted in the most significant growth response in R. asiaticus under normal and drought stress conditions. Moreover, under stressful conditions compared with no treatment, exogenously applied MT induced the appearance of flower buds 21 days early and increased relative water content by 6.4%, proline contents by 32%, and peroxidase activity by 58% while reducing electrolyte leakage by 14.3%. Regarding tolerance index percentages, higher peroxidase and proline contents indicated their suitability for use as markers for drought tolerance, supporting the effective role of exogenous MT in enhancing the adaptability of Ranunculus to drought stress.
Impact of Social Support on Depressive Symptoms among Postgraduates during the Coronavirus Disease 2019 Pandemic: A Moderated Mediation Analysis
Authors: Wan Peng , Hu Jinsheng , Li Qi
Published: February 2023

The coronavirus disease (COVID-19) pandemic continues to spread worldwide, and its related stressors are causing a high prevalence of mental health problems among graduate students. This has the potential for long-term effects on their mental well-being. However, few large-scale studies have been conducted on multiple risk and protective factors. Therefore, we aimed to test the impact of social support on depressive symptoms among graduate students and analyze the mediating role of positive coping and the regulatory role of neuroticism. From 1–8 October 2021, 1812 Chinese graduate students were surveyed online. We used a structural equation model to study the mediating role of positive coping in the relationship between social support and depressive symptoms and used the Hayes PROCESS macro to conduct mediating analysis. The incidence of depressive symptoms was 10.40%. These results showed that positive coping influenced the social support’s influence on depression symptoms to some extent. Moreover, neuroticism regulates the indirect relationship between social support and depressive symptoms through active coping. Further research is needed to assess the impact of various forms of social support on graduate students’ mental health and to develop strategies for maintaining their well-being, such as network mindfulness.
Outcomes of Transcatheter Aortic Valve Implantation Comparing Medtronic’s Evolut PRO and Evolut R: A Systematic Review and Meta-Analysis of Observational Studies
Authors: Gozdek Mirosław , Kuźma Łukasz , Dąbrowski Emil Julian , Janiak Michał , Pietrzak Martyna , Skonieczna Karolina , Woźnica Mikołaj , Wydeheft Lidia , Makhoul Maged , Matteucci Matteo , Litwinowicz Radosław , Kowalówka Adam , Wańha Wojciech , Pasierski Michał , Ronco Daniele , Massimi Giulio , Jiritano Federica , Fina Dario , Martucci Gennaro , Raffa Giuseppe Maria , Suwalski Piotr , Lorusso Roberto , Meani Paolo , Kowalewski Mariusz
Published: February 2023

Background: Transcatheter aortic valve implantation (TAVI) has become a broadly acceptable alternative to AV surgery in patients with aortic stenosis (AS). New valve designs are becoming available to address the shortcomings of their predecessors and improve clinical outcomes. Methods: A systematic review and meta-analysis was carried out to compare Medtronic’s Evolut PRO, a new valve, with the previous Evolut R design. Procedural, functional and clinical endpoints according to the VARC-2 criteria were assessed. Results: Eleven observational studies involving N = 12,363 patients were included. Evolut PRO patients differed regarding age (p < 0.001), sex (p < 0.001) and STS–PROM estimated risk. There was no difference between the two devices in terms of TAVI-related early complications and clinical endpoints. A 35% reduction of the risk of moderate-to-severe paravalvular leak (PVL) favoring the Evolut PRO was observed (RR 0.66, 95%CI, [0.52, 0.86] p = 0.002; I2 = 0%). Similarly, Evolut PRO-treated patients demonstrated a reduction of over 35% in the risk of serious bleeding as compared with the Evolut R (RR 0.63, 95%CI, [0.41, 0.96]; p = 0.03; I2 = 39%), without differences in major vascular complications. Conclusions: The evidence shows good short-term outcomes of both the Evolut PRO and Evolut R prostheses, with no differences in clinical and procedural endpoints. The Evolut PRO was associated with a lower rate of moderate-to-severe PVL and major bleeding.
Positive Self-Disclosure on Social Network Sites and Adolescents’ Friendship Quality: The Mediating Role of Positive Feedback and the Moderating Role of Social Anxiety
Authors: Liu Lizhong , Zhang Tianyi , Han Lei
Published: February 2023

In the current information age, SNSs (Social Network Sites) have been popular among young adolescents, and have also become a main manner to maintain social relationships. Against this background, based on relevant evidence, the present study aimed to examine the association between positive self-disclosure on SNSs and adolescents’ friendship quality, as well as the underlying mechanism—the potential mediating role of perceived positive feedback and the moderating role of social anxiety. A sample of 1713 adolescents aged 11 to 19 was recruited to participate in this study, to complete a set of scales. Results indicated that positive self-disclosure on SNSs was positively associated with adolescents’ friendship quality, and positive feedback significantly mediated the association between self-disclosure positivity and friendship quality. This mediating effect, moderated by social anxiety, could significantly moderate the mediating effect of positive feedback; specifically, compared with higher social anxiety adolescents, the association between positive self-disclosure and positive feedback was stronger among individuals with lower social anxiety. These findings may expand previous studies, with several theoretical and practical implications.
Gender Composition in Occupational Therapy Journals’ Editorial Boards
Authors: Mendoza-Holgado Cristina , Cantero-Garlito Pablo A. , Barrios-Fernandez Sabina
Published: February 2023

This paper analyses the Editorial Board (EB) distribution of Occupational Therapy journals from a gender perspective. The “Occupational Therapy” field in the Scimago Journal and Country Rank (SJR) and the “Occupational Therapy” term in the title search of the Journal Citation Report (JCR) were used to find the Occupational Therapy-specific journals. The following indicators were calculated: Editorial Board Member (EBM) gender distribution by journal, publisher, subject speciality, country, and journal quartile. Thirty-seven journals were located, including 667 individuals, 206 males (31%) and 461 females (69%). Referring to the EB positions, most members (557) were EB members, 70 were listed as Associate Editors, and 20 as Editorial Leaders. The results show that the proportion of women in the EB’s of Occupational Therapy journals represents a majority. Regarding the distribution by gender of the EBMs, six journals had a female proportion below the cut-off point revealed in this study (69%). Four did not reach parity, with female representation below 50%. Additionally, the balance among the EBMs is significantly underrepresented compared to the percentage of female Occupational Therapy practitioners.