bluuebunny/crossref_metadata_2025 huggingface dataset:
Supplementary Methods and References from Dsh Homolog DVL3 Mediates Resistance to IGFIR Inhibition by Regulating IGF-RAS Signaling
Authors: Gao Shan , Bajrami Ilirjana , Verrill Clare , Kigozi Asha , Ouaret Djamila , Aleksic Tamara , Asher Ruth , Han Cheng , Allen Paul , Bailey Deborah , Feller Stephan , Kashima Takeshi , Athanasou Nicholas , Blay Jean-Yves , Schmitz Sandra , Machiels Jean-Pascal , Upile Nav , Jones Terry M. , Thalmann George , Ashraf Shazad Q. , Wilding Jennifer L. , Bodmer Walter F. , Middleton Mark R. , Ashworth Alan , Lord Christopher J. , Macaulay Valentine M.
Published: March 2023

Supplementary Methods and References. Description of additional methods and procedures used in the study. Also includes supplementary references.
Supplementary Figures S1-S6 from Dsh Homolog DVL3 Mediates Resistance to IGFIR Inhibition by Regulating IGF-RAS Signaling
Authors: Gao Shan , Bajrami Ilirjana , Verrill Clare , Kigozi Asha , Ouaret Djamila , Aleksic Tamara , Asher Ruth , Han Cheng , Allen Paul , Bailey Deborah , Feller Stephan , Kashima Takeshi , Athanasou Nicholas , Blay Jean-Yves , Schmitz Sandra , Machiels Jean-Pascal , Upile Nav , Jones Terry M. , Thalmann George , Ashraf Shazad Q. , Wilding Jennifer L. , Bodmer Walter F. , Middleton Mark R. , Ashworth Alan , Lord Christopher J. , Macaulay Valentine M.
Published: March 2023

Supplementary Figures S1-S6. S1: Sensitivity to IGFâ€�1R inhibitor AZ12253801 is influenced by levels of DVL3 protein but not IGFâ€�1R or INSR S2: Effects of HUNK depletion on IGF signalling S3: Sensitivity to IGFâ€�1R inhibition is enhanced by proximal but not distal WNT pathway inhibition S4: Investigating effects of DVL3 on IGFâ€�induced ERK activation in prostate and breast cancer cells S5: ERK activation induced by DVL inhibition is independent of EGFR and IRSâ€�1, and involves complex formation with adaptor proteins Grb2, DAB2 and SOS S6: DVL3 immunohistochemistry
Data Supplement from Trim32 Facilitates Degradation of MYCN on Spindle Poles and Induces Asymmetric Cell Division in Human Neuroblastoma Cells
Authors: Izumi Hideki , Kaneko Yasuhiko
Published: March 2023

Supplementary Figure S11. ACD and distribution of Trim32 and MYCN. Representative images of Flag- and MYCN-stained SK-N-DZ cells transfected with the Flag-trim32 or Flag-Trim32/3A expression vector. Flag is green, MYCN is red, and DAPI (DNA) is blue. Arrows show Trim32-positive daughter cells. Arrowheads show MYCN-positive daughter cells. Dashed outlines show a pair of daughter cells.
Supplementary Materials and Methods from Cancer-Associated Adipose Tissue Promotes Breast Cancer Progression by Paracrine Oncostatin M and Jak/STAT3 Signaling
Authors: Lapeire Lore , Hendrix An , Lambein Kathleen , Van Bockstal Mieke , Braems Geert , Van Den Broecke Rudy , Limame Ridha , Mestdagh Pieter , Vandesompele Jo , Vanhove Christian , Maynard Dawn , Lehuédé Camille , Muller Catherine , Valet Philippe , Gespach Christian P. , Bracke Marc , Cocquyt Veronique , Denys Hannelore , De Wever Olivier
Published: March 2023

Supplemental materials and methods in addition to those mentioned in the manuscript.
Supplementary Figure 6 from Cancer-Associated Adipose Tissue Promotes Breast Cancer Progression by Paracrine Oncostatin M and Jak/STAT3 Signaling
Authors: Lapeire Lore , Hendrix An , Lambein Kathleen , Van Bockstal Mieke , Braems Geert , Van Den Broecke Rudy , Limame Ridha , Mestdagh Pieter , Vandesompele Jo , Vanhove Christian , Maynard Dawn , Lehuédé Camille , Muller Catherine , Valet Philippe , Gespach Christian P. , Bracke Marc , Cocquyt Veronique , Denys Hannelore , De Wever Olivier
Published: March 2023

Left panel: Graph representing proliferation rate of MCF-7-GFP and MCF-7-OSM cells in time (asterix indicates P = .068). Right upper panel: images of MCF-7-GFP and MCF-7-OSM aggregates embedded in type I collagen (scale bar is 100 µm). Right lower panel: Graph representing relative mRNA levels of OSMR, LIFR, GP130 and STAT3 in MCF-7-GFP and MCF-7-OSM cells.
Supplementary Figure 4 from Cancer-Associated Adipose Tissue Promotes Breast Cancer Progression by Paracrine Oncostatin M and Jak/STAT3 Signaling
Authors: Lapeire Lore , Hendrix An , Lambein Kathleen , Van Bockstal Mieke , Braems Geert , Van Den Broecke Rudy , Limame Ridha , Mestdagh Pieter , Vandesompele Jo , Vanhove Christian , Maynard Dawn , Lehuédé Camille , Muller Catherine , Valet Philippe , Gespach Christian P. , Bracke Marc , Cocquyt Veronique , Denys Hannelore , De Wever Olivier
Published: March 2023

Graphs representing relative mRNA levels of OSMR, LIFR, GP130 and STAT3 in MCF-7 and SKBR3 cells treated for 48h with control medium or rhOSM (2 ng/ml).
Data Supplement from Trim32 Facilitates Degradation of MYCN on Spindle Poles and Induces Asymmetric Cell Division in Human Neuroblastoma Cells
Authors: Izumi Hideki , Kaneko Yasuhiko
Published: March 2023

Supplementary Figure S6. Evaluation of different doses Cdk1/ Cyclin B inhibitor (RO-3306) treatment in neuroblastoma cells. Cells (SK-N-DZ) were treated with 50ng/ml of nocodazole (Noc) with or without low or high concentration (5μM or 10μM) of RO-3306 for 3h. The treated samples were then subjected to immunoblot analysis. RO-3306 treatment reduced Cyclin B and phospho-histone H3 (a mitosis marker) levels in a dose dependent manner as reported previously (1). 1. Vassilev LT, Tovar C, Chen S, Knezevic D, Zhao X, Sun H, et al. Selective small-molecule inhibitor reveals critical mitotic functions of human CDK1. Proceedings of the National Academy of Sciences of the United States of America. 2006;103:10660-5.
Data Supplement from Trim32 Facilitates Degradation of MYCN on Spindle Poles and Induces Asymmetric Cell Division in Human Neuroblastoma Cells
Authors: Izumi Hideki , Kaneko Yasuhiko
Published: March 2023

Supplementary Figure S7. The Cdk1/cyclin B inhibitor (RO-3306) suppresses spindle pole localization of Trim32. Percent of TGW (upper panels) or SN-N-DZ (lower panel) cells with intense, weak, or no spindle pole localization of Trim32 with or without RO-3306 treatment. Error bars represent SEM from three experiments. Localization statuses of Trim32 to spindle poles was categorized with three types (intense, weak or no localization).
Data Supplement from Trim32 Facilitates Degradation of MYCN on Spindle Poles and Induces Asymmetric Cell Division in Human Neuroblastoma Cells
Authors: Izumi Hideki , Kaneko Yasuhiko
Published: March 2023

Sup. Figure Legend
Supplementary Table 4 from Inhibiting Tankyrases Sensitizes KRAS-Mutant Cancer Cells to MEK Inhibitors via FGFR2 Feedback Signaling
Authors: Schoumacher Marie , Hurov Kristen E. , Lehár Joseph , Yan-Neale Yan , Mishina Yuji , Sonkin Dmitriy , Korn Joshua M. , Flemming Daisy , Jones Michael D. , Antonakos Brandon , Cooke Vesselina G. , Steiger Janine , Ledell Jebediah , Stump Mark D. , Sellers William R. , Danial Nika N. , Shao Wenlin
Published: March 2023

PDF file - 54KB, Chemical inhibitors used in the study.
Supplementary Table 1 from Inhibiting Tankyrases Sensitizes KRAS-Mutant Cancer Cells to MEK Inhibitors via FGFR2 Feedback Signaling
Authors: Schoumacher Marie , Hurov Kristen E. , Lehár Joseph , Yan-Neale Yan , Mishina Yuji , Sonkin Dmitriy , Korn Joshua M. , Flemming Daisy , Jones Michael D. , Antonakos Brandon , Cooke Vesselina G. , Steiger Janine , Ledell Jebediah , Stump Mark D. , Sellers William R. , Danial Nika N. , Shao Wenlin
Published: March 2023

PDF file - 81KB, List of identified synergistic cell lines for TNKSi/MEKi combination in the large-scale combination screen and their KRAS status. KRAS mutants are in red.
Supplementary Tables 1 through 6 from Patient-Derived Ovarian Tumor Xenografts Recapitulate Human Clinicopathology and Genetic Alterations
Authors: Ricci Francesca , Bizzaro Francesca , Cesca Marta , Guffanti Federica , Ganzinelli Monica , Decio Alessandra , Ghilardi Carmen , Perego Patrizia , Fruscio Robert , Buda Alessandro , Milani Rodolfo , Ostano Paola , Chiorino Giovanna , Bani Maria Rosa , Damia Giovanna , Giavazzi Raffaella
Published: March 2023

Supplementary Table 1.Primers used for PCR amplification and sequencing Table 2. Clinico-pathological characteristics of the patients from which tumor specimens were trasplanted in nude mice. Table 3.Correlation analysis between engrafted and no-engrafted tumors. Table 4. Mutational spectrum of different genes in EOC-xenograft and corresponding patient tumor Table 5. Genes copy number in EOC-xenoograft and corresponding patient tumors Table 6. Functional analysis on genes differentially expressed in EOC-xenografts and corresponding patient tumors
Supplementary Materials, Figure Legends, Table Legends from Inhibiting Tankyrases Sensitizes KRAS-Mutant Cancer Cells to MEK Inhibitors via FGFR2 Feedback Signaling
Authors: Schoumacher Marie , Hurov Kristen E. , Lehár Joseph , Yan-Neale Yan , Mishina Yuji , Sonkin Dmitriy , Korn Joshua M. , Flemming Daisy , Jones Michael D. , Antonakos Brandon , Cooke Vesselina G. , Steiger Janine , Ledell Jebediah , Stump Mark D. , Sellers William R. , Danial Nika N. , Shao Wenlin
Published: March 2023

PDF file - 123KB
Supplementary Information from Patient-Derived Ovarian Tumor Xenografts Recapitulate Human Clinicopathology and Genetic Alterations
Authors: Ricci Francesca , Bizzaro Francesca , Cesca Marta , Guffanti Federica , Ganzinelli Monica , Decio Alessandra , Ghilardi Carmen , Perego Patrizia , Fruscio Robert , Buda Alessandro , Milani Rodolfo , Ostano Paola , Chiorino Giovanna , Bani Maria Rosa , Damia Giovanna , Giavazzi Raffaella
Published: March 2023

Supplementary Information
Supplementary Figures 1 - 6 from Inhibiting Tankyrases Sensitizes KRAS-Mutant Cancer Cells to MEK Inhibitors via FGFR2 Feedback Signaling
Authors: Schoumacher Marie , Hurov Kristen E. , Lehár Joseph , Yan-Neale Yan , Mishina Yuji , Sonkin Dmitriy , Korn Joshua M. , Flemming Daisy , Jones Michael D. , Antonakos Brandon , Cooke Vesselina G. , Steiger Janine , Ledell Jebediah , Stump Mark D. , Sellers William R. , Danial Nika N. , Shao Wenlin
Published: March 2023

PDF file - 660KB, Supplementary Figure S1. All RAS mutant cell lines have a higher sensitivity to the TNKSi/MEKi combination. Supplementary Figure S2. Validation of TNKSi/MEKi combination in KRAS mutant cancer cells. Supplementary Figure S3. Combinations with MEK inhibitor in the SW480 cell line. Supplementary Figure S4. TNKSi/MEKi combination leads to enhanced inhibition of AKT signaling activity. Supplementary Figure S5. TNKSi potentiates MEKi by releasing a feedback loop on FGFR2 signaling. Supplementary Figure S6. Consequences of combined inhibition of TNKS and MEK on FGFR2 and AKT signaling pathways in KRAS mutant cell lines.
Supplementary Figure 5 from Patient-Derived Ovarian Tumor Xenografts Recapitulate Human Clinicopathology and Genetic Alterations
Authors: Ricci Francesca , Bizzaro Francesca , Cesca Marta , Guffanti Federica , Ganzinelli Monica , Decio Alessandra , Ghilardi Carmen , Perego Patrizia , Fruscio Robert , Buda Alessandro , Milani Rodolfo , Ostano Paola , Chiorino Giovanna , Bani Maria Rosa , Damia Giovanna , Giavazzi Raffaella
Published: March 2023

Supplementary Figure 5. Pearson's correlation coefficient across all EOCs.
Supplementary Figure 4 from Patient-Derived Ovarian Tumor Xenografts Recapitulate Human Clinicopathology and Genetic Alterations
Authors: Ricci Francesca , Bizzaro Francesca , Cesca Marta , Guffanti Federica , Ganzinelli Monica , Decio Alessandra , Ghilardi Carmen , Perego Patrizia , Fruscio Robert , Buda Alessandro , Milani Rodolfo , Ostano Paola , Chiorino Giovanna , Bani Maria Rosa , Damia Giovanna , Giavazzi Raffaella
Published: March 2023

Supplementary Figure 4. Gene copy number in patient and xenograft
Supplementary Figure 2 from Patient-Derived Ovarian Tumor Xenografts Recapitulate Human Clinicopathology and Genetic Alterations
Authors: Ricci Francesca , Bizzaro Francesca , Cesca Marta , Guffanti Federica , Ganzinelli Monica , Decio Alessandra , Ghilardi Carmen , Perego Patrizia , Fruscio Robert , Buda Alessandro , Milani Rodolfo , Ostano Paola , Chiorino Giovanna , Bani Maria Rosa , Damia Giovanna , Giavazzi Raffaella
Published: March 2023

Supplementary Figure 2. Comparative immuno-histologic analysis of patient tumor and the corresponding xenograft.
Supplementary Table 1 from Separating Tumorigenicity from Bile Acid Regulatory Activity for Endocrine Hormone FGF19
Authors: Zhou Mei , Wang Xueyan , Phung Van , Lindhout Darrin A. , Mondal Kalyani , Hsu Jer-Yuan , Yang Hong , Humphrey Mark , Ding Xunshan , Arora Taruna , Learned R. Marc , DePaoli Alex M. , Tian Hui , Ling Lei
Published: March 2023

PDF file - 142KB, Supplementary Table S1. Serum Parameters of db/db Mice After Continuous Exposure to FGF19 or M70 for 24 Weeks.
Supplementary Fig. 4 from Metastasis Stimulation by Hypoxia and Acidosis-Induced Extracellular Lipid Uptake Is Mediated by Proteoglycan-Dependent Endocytosis
Authors: Menard Julien A. , Christianson Helena C. , Kucharzewska Paulina , Bourseau-Guilmain Erika , Svensson Katrin J. , Lindqvist Eva , Chandran Vineesh Indira , Kjellén Lena , Welinder Charlotte , Bengzon Johan , Johansson Maria C. , Belting Mattias
Published: March 2023

Figure S4. A, Efficient digestion of HS chains. B,C, Cell-surface lipoprotein binding in normoxia and hypoxia.
Data Supplement from The SIRT1/HIF2α Axis Drives Reductive Glutamine Metabolism under Chronic Acidosis and Alters Tumor Response to Therapy
Authors: Corbet Cyril , Draoui Nihed , Polet Florence , Pinto Adan , Drozak Xavier , Riant Olivier , Feron Olivier
Published: March 2023

Supplementary Figure S3. Chronic acidosis decreases glucose-fueled respiration.
Data Supplement from The SIRT1/HIF2α Axis Drives Reductive Glutamine Metabolism under Chronic Acidosis and Alters Tumor Response to Therapy
Authors: Corbet Cyril , Draoui Nihed , Polet Florence , Pinto Adan , Drozak Xavier , Riant Olivier , Feron Olivier
Published: March 2023

Supplementary Figure S5. Acidosis-triggered metabolic shift is reversible in FaDu and HCT-116 tumor cells.
Data Supplement from The SIRT1/HIF2α Axis Drives Reductive Glutamine Metabolism under Chronic Acidosis and Alters Tumor Response to Therapy
Authors: Corbet Cyril , Draoui Nihed , Polet Florence , Pinto Adan , Drozak Xavier , Riant Olivier , Feron Olivier
Published: March 2023

Legends for Supplementary Figures S1-S6.
Supplementary Table 5 from The 19q12 Bladder Cancer GWAS Signal: Association with Cyclin E Function and Aggressive Disease
Authors: Fu Yi-Ping , Kohaar Indu , Moore Lee E. , Lenz Petra , Figueroa Jonine D. , Tang Wei , Porter-Gill Patricia , Chatterjee Nilanjan , Scott-Johnson Alexandra , Garcia-Closas Montserrat , Muchmore Brian , Baris Dalsu , Paquin Ashley , Ylaya Kris , Schwenn Molly , Apolo Andrea B. , Karagas Margaret R. , Tarway McAnthony , Johnson Alison , Mumy Adam , Schned Alan , Guedez Liliana , Jones Michael A. , Kida Masatoshi , Hosain GM Monawar , Malats Nuria , Kogevinas Manolis , Tardon Adonina , Serra Consol , Carrato Alfredo , Garcia-Closas Reina , Lloreta Josep , Wu Xifeng , Purdue Mark , Andriole Gerald L. , Grubb Robert L. , Black Amanda , Landi Maria T. , Caporaso Neil E. , Vineis Paolo , Siddiq Afshan , Bueno-de-Mesquita H. Bas , Trichopoulos Dimitrios , Ljungberg Börje , Severi Gianluca , Weiderpass Elisabete , Krogh Vittorio , Dorronsoro Miren , Travis Ruth C. , Tjønneland Anne , Brennan Paul , Chang-Claude Jenny , Riboli Elio , Prescott Jennifer , Chen Constance , De Vivo Immaculata , Govannucci Edward , Hunter David , Kraft Peter , Lindstrom Sara , Gapstur Susan M. , Jacobs Eric J. , Diver W. Ryan , Albanes Demetrius , Weinstein Stephanie J. , Virtamo Jarmo , Kooperberg Charles , Hohensee Chancellor , Rodabough Rebecca J. , Cortessis Victoria K. , Conti David V. , Gago-Dominguez Manuela , Stern Mariana C. , Pike Malcolm C. , Van Den Berg David , Yuan Jian-Min , Haiman Christopher A. , Cussenot Olivier , Cancel-Tassin Geraldine , Roupret Morgan , Comperat Eva , Porru Stefano , Carta Angela , Pavanello Sofia , Arici Cecilia , Mastrangelo Giuseppe , Grossman H. Barton , Wang Zhaoming , Deng Xiang , Chung Charles C. , Hutchinson Amy , Burdette Laurie , Wheeler William , Fraumeni Joseph , Chanock Stephen J. , Hewitt Stephen M. , Silverman Debra T. , Rothman Nathaniel , Prokunina-Olsson Ludmila
Published: March 2023

Association between CCNE1 variants and bladder cancer
Supplementary Figure S2 from β-Catenin Contributes to Lung Tumor Development Induced by EGFR Mutations
Authors: Nakayama Sohei , Sng Natasha , Carretero Julian , Welner Robert , Hayashi Yuichiro , Yamamoto Mihoko , Tan Alistair J. , Yamaguchi Norihiro , Yasuda Hiroyuki , Li Danan , Soejima Kenzo , Soo Ross A. , Costa Daniel B. , Wong Kwok-Kin , Kobayashi Susumu S.
Published: March 2023

Expression of β-catenin in pre- and post-EGFR TKIs lung biopsies.
Data Supplement from RB Family Tumor Suppressor Activity May Not Relate to Active Silencing of E2F Target Genes
Authors: Vormer Tinke L. , Wojciechowicz Kamila , Dekker Marleen , de Vries Sandra , van der Wal Anja , Delzenne-Goette Elly , Naik Sjalin H. , Song Ji-Ying , Dannenberg Jan-Hermen , Hansen Jacob B. , te Riele Hein
Published: March 2023

Supplementary Table S1. Genotypic analysis of life born animals derived from RbN750F/wtp130+/- intercrosses.
Data Supplement from RB Family Tumor Suppressor Activity May Not Relate to Active Silencing of E2F Target Genes
Authors: Vormer Tinke L. , Wojciechowicz Kamila , Dekker Marleen , de Vries Sandra , van der Wal Anja , Delzenne-Goette Elly , Naik Sjalin H. , Song Ji-Ying , Dannenberg Jan-Hermen , Hansen Jacob B. , te Riele Hein
Published: March 2023

Supplementary Figure S1. RbN750F/N750Fp130-/- MEFs express wild-type levels of pRB, but increased levels of E2F-target genes.
Data Supplement from RB Family Tumor Suppressor Activity May Not Relate to Active Silencing of E2F Target Genes
Authors: Vormer Tinke L. , Wojciechowicz Kamila , Dekker Marleen , de Vries Sandra , van der Wal Anja , Delzenne-Goette Elly , Naik Sjalin H. , Song Ji-Ying , Dannenberg Jan-Hermen , Hansen Jacob B. , te Riele Hein
Published: March 2023

Supplementary Figure S2. The pRB-LxCxE interaction is involved in cell cycle arrest after γ-irradiation.
Supplementary Figure 8 from Loss of Cdk2 and Cyclin A2 Impairs Cell Proliferation and Tumorigenesis
Authors: Gopinathan Lakshmi , Tan Shawn Lu Wen , Padmakumar V. C. , Coppola Vincenzo , Tessarollo Lino , Kaldis Philipp
Published: March 2023

PDF file - 58KB, Biochemical analysis of primary MEFs.
Supplementary Figure 7 from Loss of Cdk2 and Cyclin A2 Impairs Cell Proliferation and Tumorigenesis
Authors: Gopinathan Lakshmi , Tan Shawn Lu Wen , Padmakumar V. C. , Coppola Vincenzo , Tessarollo Lino , Kaldis Philipp
Published: March 2023

PDF file - 301KB, FACS analysis after induction of cyclin A2 loss in immortalized MEFs and biochemical analysis of primary MEFs.
Supplementary Figure 5 from EWS–WT1 Oncoprotein Activates Neuronal Reprogramming Factor ASCL1 and Promotes Neural Differentiation
Authors: Kang Hong-Jun , Park Jun Hong , Chen WeiPing , Kang Soo Im , Moroz Krzysztof , Ladanyi Marc , Lee Sean Bong
Published: March 2023

PDF file - 46K, Expression of E-KTS induces partial neural differentiation.
Supplementary Figure 4 from EWS–WT1 Oncoprotein Activates Neuronal Reprogramming Factor ASCL1 and Promotes Neural Differentiation
Authors: Kang Hong-Jun , Park Jun Hong , Chen WeiPing , Kang Soo Im , Moroz Krzysztof , Ladanyi Marc , Lee Sean Bong
Published: March 2023

PDF file - 378K, ASCL1 promoter activation is mediated by multiple E-KTS binding sites.
Supplementary Figure Legends from Network Modeling of TGFβ Signaling in Hepatocellular Carcinoma Epithelial-to-Mesenchymal Transition Reveals Joint Sonic Hedgehog and Wnt Pathway Activation
Authors: Steinway Steven Nathaniel , Zañudo Jorge G.T. , Ding Wei , Rountree Carl Bart , Feith David J. , Loughran Thomas P. , Albert Reka
Published: March 2023

Legend for Supplementary Figures S1-S5.
Supplementary Tables 1 - 3 from Autologous T-cell Therapy for Cytomegalovirus as a Consolidative Treatment for Recurrent Glioblastoma
Authors: Schuessler Andrea , Smith Corey , Beagley Leone , Boyle Glen M. , Rehan Sweera , Matthews Katherine , Jones Linda , Crough Tania , Dasari Vijayendra , Klein Kerenaftali , Smalley Amy , Alexander Hamish , Walker David G. , Khanna Rajiv
Published: March 2023

PDF file - 62KB, List of CMV epitopes used for in vitro stimulation (S1). List of epitopes used for in vitro T cell expansion and patient responses (S2). List of genes included in taqman array (S3).
Supplementary Figure Legends from Autologous T-cell Therapy for Cytomegalovirus as a Consolidative Treatment for Recurrent Glioblastoma
Authors: Schuessler Andrea , Smith Corey , Beagley Leone , Boyle Glen M. , Rehan Sweera , Matthews Katherine , Jones Linda , Crough Tania , Dasari Vijayendra , Klein Kerenaftali , Smalley Amy , Alexander Hamish , Walker David G. , Khanna Rajiv
Published: March 2023

PDF file - 54KB
Supplemental Table 1 from Force Engages Vinculin and Promotes Tumor Progression by Enhancing PI3K Activation of Phosphatidylinositol (3,4,5)-Triphosphate
Authors: Rubashkin Matthew G. , Cassereau Luke , Bainer Russell , DuFort Christopher C. , Yui Yoshihiro , Ou Guanqing , Paszek Matthew J. , Davidson Michael W. , Chen Yunn-Yi , Weaver Valerie M.
Published: March 2023

List of Adhesome, Oncogene and Control Genes used in Bioinformatics Analysis.
Supplemental Methods, References and Figure Legends from Force Engages Vinculin and Promotes Tumor Progression by Enhancing PI3K Activation of Phosphatidylinositol (3,4,5)-Triphosphate
Authors: Rubashkin Matthew G. , Cassereau Luke , Bainer Russell , DuFort Christopher C. , Yui Yoshihiro , Ou Guanqing , Paszek Matthew J. , Davidson Michael W. , Chen Yunn-Yi , Weaver Valerie M.
Published: March 2023

Supplemental Methods, References, and Figure Legends
Supplemental Figure 4 from Force Engages Vinculin and Promotes Tumor Progression by Enhancing PI3K Activation of Phosphatidylinositol (3,4,5)-Triphosphate
Authors: Rubashkin Matthew G. , Cassereau Luke , Bainer Russell , DuFort Christopher C. , Yui Yoshihiro , Ou Guanqing , Paszek Matthew J. , Davidson Michael W. , Chen Yunn-Yi , Weaver Valerie M.
Published: March 2023

Scanning angle interference microscopy - validation experiments.
Supplemental Figure 3 from Force Engages Vinculin and Promotes Tumor Progression by Enhancing PI3K Activation of Phosphatidylinositol (3,4,5)-Triphosphate
Authors: Rubashkin Matthew G. , Cassereau Luke , Bainer Russell , DuFort Christopher C. , Yui Yoshihiro , Ou Guanqing , Paszek Matthew J. , Davidson Michael W. , Chen Yunn-Yi , Weaver Valerie M.
Published: March 2023

Vinculin nanoscale localization reflects altered molecular activity.
Data Supplement from Combined SFK/mTOR Inhibition Prevents Rapamycin-Induced Feedback Activation of AKT and Elicits Efficient Tumor Regression
Authors: Yori Jennifer L. , Lozada Kristen L. , Seachrist Darcie D. , Mosley Jonathan D. , Abdul-Karim Fadi W. , Booth Christine N. , Flask Chris A. , Keri Ruth A.
Published: March 2023

Supplementary Figure S6. The combination of dasatinib and rapamycin induces tumor regression of MMTV-PyMT-induced mammary tumors.
Supplementary Table S2 from TRAP1 Is Involved in BRAF Regulation and Downstream Attenuation of ERK Phosphorylation and Cell-Cycle Progression: A Novel Target for BRAF-Mutated Colorectal Tumors
Authors: Condelli Valentina , Piscazzi Annamaria , Sisinni Lorenza , Matassa Danilo Swann , Maddalena Francesca , Lettini Giacomo , Simeon Vittorio , Palladino Giuseppe , Amoroso Maria Rosaria , Trino Stefania , Esposito Franca , Landriscina Matteo
Published: March 2023

TRAP1 and BRAF protein levels in 41 human BRAF-wild type colorectal carcinomas expressed as time increase in tumor compared to correspondent non-infiltrated peritumoral mucosas.
Supplmentary File 2 from Nuclear Factor of Activated T-cell Activity Is Associated with Metastatic Capacity in Colon Cancer
Authors: Tripathi Manish K. , Deane Natasha G. , Zhu Jing , An Hanbing , Mima Shinji , Wang Xiaojing , Padmanabhan Sekhar , Shi Zhiao , Prodduturi Naresh , Ciombor Kristen K. , Chen Xi , Washington M. Kay , Zhang Bing , Beauchamp R. Daniel
Published: March 2023

Supplmentary File 2. Genes in 441 co-expression modules identified within the integrated colon cancer co-expression network.
Supplementary Figure S4 from TRAP1 Is Involved in BRAF Regulation and Downstream Attenuation of ERK Phosphorylation and Cell-Cycle Progression: A Novel Target for BRAF-Mutated Colorectal Tumors
Authors: Condelli Valentina , Piscazzi Annamaria , Sisinni Lorenza , Matassa Danilo Swann , Maddalena Francesca , Lettini Giacomo , Simeon Vittorio , Palladino Giuseppe , Amoroso Maria Rosaria , Trino Stefania , Esposito Franca , Landriscina Matteo
Published: March 2023

HSP990 induces downregulation of specific protein of TRAP1 network and inhibits cell proliferation. A-B. Mitochondrial (A) and total cell (B) lysates from HT29 cells were separated by SDS-PAGE and immunoblotted with anti-sorcin and anti-VDAC (A) or anti-eEF1G, anti-eIF4A, anti-eIF4E and anti-GAPDH (B) antibodies. C-D. Inhibition of cell proliferation (C) and induction of apoptosis (D) in HT29 cells treated with increasing concentrations of AUY922 and HSP990 for indicated time points. C. *p<0.0001 versus cells treated with the same concentration of AUY922. D. *p=0.005; **p<0.0001; {degree sign}p=0.006 versus control cells.
Supplementary Figure S3 from TRAP1 Is Involved in BRAF Regulation and Downstream Attenuation of ERK Phosphorylation and Cell-Cycle Progression: A Novel Target for BRAF-Mutated Colorectal Tumors
Authors: Condelli Valentina , Piscazzi Annamaria , Sisinni Lorenza , Matassa Danilo Swann , Maddalena Francesca , Lettini Giacomo , Simeon Vittorio , Palladino Giuseppe , Amoroso Maria Rosaria , Trino Stefania , Esposito Franca , Landriscina Matteo
Published: March 2023

A-B. Total cell lysates from siTRAP1 HCT116 and HT29 cells (A) or HCT116 cells transfected with pMock or TRAP1 cDNA (B) were separated by SDS-PAGE and immunoblotted with indicated antibodies. C. Cell cycle distribution in HCT116 cells transfected individually or in combination with negative, TFDP1, PBK, CCNE1, or NEK6 siRNA (*p=<0.0001; **p=0.002; {degree sign}p=0.006, {degree sign}{degree sign}p=0.004 versus Neg siRNA transfected cells). Insert: Total cell lysates from HCT116 cells transfected individually or combination with negative, TFDP1, PBK, CCNE1, or NEK siRNA were separated by SDS-PAGE and immunoblotted with indicated antibodies.
Supplementary Figure S2 from TRAP1 Is Involved in BRAF Regulation and Downstream Attenuation of ERK Phosphorylation and Cell-Cycle Progression: A Novel Target for BRAF-Mutated Colorectal Tumors
Authors: Condelli Valentina , Piscazzi Annamaria , Sisinni Lorenza , Matassa Danilo Swann , Maddalena Francesca , Lettini Giacomo , Simeon Vittorio , Palladino Giuseppe , Amoroso Maria Rosaria , Trino Stefania , Esposito Franca , Landriscina Matteo
Published: March 2023

A. Gene ontology categories associated to genes up/downregulated upon TRAP1 silencing in HCT116 cells. B. Top predicted biofunctions associated to genes downregulated upon TRAP1 silencing in HCT116 cells. Color intensity for each biofunction corresponds to p-value. Biofunction prediction from Fidea software. C. Real time gene expression analysis of previously validated genes in HT29 cells upon TRAP1 transient interference (*p=<0.0001; **p=0.003; ***p=0.002; {degree sign}p=0.001). Insert: TRAP1 expression evaluated by immunoblot in scramble (1) and siTRAP1 (2) HT29 cells.
Supp Table S3 from In Vivo Disruption of an Rb–E2F–Ezh2 Signaling Loop Causes Bladder Cancer
Authors: Santos Mirentxu , Martínez-Fernández Mónica , Dueñas Marta , García-Escudero Ramón , Alfaya Begoña , Villacampa Felipe , Saiz-Ladera Cristina , Costa Clotilde , Oteo Marta , Duarte José , Martínez Victor , Gómez-Rodriguez Ma José , Martín Ma Luisa , Fernández Manoli , Viatour Patrick , Morcillo Miguel A. , Sage Julien , Castellano Daniel , Rodriguez-Peralto Jose L. , de la Rosa Federico , Paramio Jesús M
Published: March 2023

Supp Table S3. Gene Ontology of Biological processes of the downregulated genes in mouse bladder tumors.
Supp Table S17 from In Vivo Disruption of an Rb–E2F–Ezh2 Signaling Loop Causes Bladder Cancer
Authors: Santos Mirentxu , Martínez-Fernández Mónica , Dueñas Marta , García-Escudero Ramón , Alfaya Begoña , Villacampa Felipe , Saiz-Ladera Cristina , Costa Clotilde , Oteo Marta , Duarte José , Martínez Victor , Gómez-Rodriguez Ma José , Martín Ma Luisa , Fernández Manoli , Viatour Patrick , Morcillo Miguel A. , Sage Julien , Castellano Daniel , Rodriguez-Peralto Jose L. , de la Rosa Federico , Paramio Jesús M
Published: March 2023

Supp Table S17. Dataset containing the list of upregulated and downregulated genes in human bladder tumors according to progression in recurrence.
Supp Table S10 from In Vivo Disruption of an Rb–E2F–Ezh2 Signaling Loop Causes Bladder Cancer
Authors: Santos Mirentxu , Martínez-Fernández Mónica , Dueñas Marta , García-Escudero Ramón , Alfaya Begoña , Villacampa Felipe , Saiz-Ladera Cristina , Costa Clotilde , Oteo Marta , Duarte José , Martínez Victor , Gómez-Rodriguez Ma José , Martín Ma Luisa , Fernández Manoli , Viatour Patrick , Morcillo Miguel A. , Sage Julien , Castellano Daniel , Rodriguez-Peralto Jose L. , de la Rosa Federico , Paramio Jesús M
Published: March 2023

Supp Table S10. Dataset containing the list of upregulated and downregulated genes in human bladder tumors according to recurrence.
Data Supplement from Armed Oncolytic Virus Enhances Immune Functions of Chimeric Antigen Receptor–Modified T Cells in Solid Tumors
Authors: Nishio Nobuhiro , Diaconu Iulia , Liu Hao , Cerullo Vincenzo , Caruana Ignazio , Hoyos Valentina , Bouchier-Hayes Lisa , Savoldo Barbara , Dotti Gianpietro
Published: March 2023

Supplementary Figure S2. Ad5ÃŽ?24 does not increase the effector function of GD2.CAR-T cells
Supplementary Script A from Discrepancies in Cancer Genomic Sequencing Highlight Opportunities for Driver Mutation Discovery
Authors: Hudson Andrew M. , Yates Tim , Li Yaoyong , Trotter Eleanor W. , Fawdar Shameem , Chapman Phil , Lorigan Paul , Biankin Andrew , Miller Crispin J. , Brognard John
Published: March 2023

Groovy program script used to make the 18 cell line comparison
Supplementary Table 1 from Colorectal Cancer Cell Lines Are Representative Models of the Main Molecular Subtypes of Primary Cancer
Authors: Mouradov Dmitri , Sloggett Clare , Jorissen Robert N. , Love Christopher G. , Li Shan , Burgess Antony W. , Arango Diego , Strausberg Robert L. , Buchanan Daniel , Wormald Samuel , O'Connor Liam , Wilding Jennifer L. , Bicknell David , Tomlinson Ian P.M. , Bodmer Walter F. , Mariadason John M. , Sieber Oliver M.
Published: March 2023

XLSX file - 23KB, CRC cell line details and major molecular hallmarks.
Supplementary Tables S1-S6 from STAT1 Drives Tumor Progression in Serous Papillary Endometrial Cancer
Authors: Kharma Budiman , Baba Tsukasa , Matsumura Noriomi , Kang Hyun Sook , Hamanishi Junzo , Murakami Ryusuke , McConechy Melissa M. , Leung Samuel , Yamaguchi Ken , Hosoe Yuko , Yoshioka Yumiko , Murphy Susan K. , Mandai Masaki , Hunstman David G. , Konishi Ikuo
Published: March 2023

Supplementary Tables S1-S6. Primer sequences (S1); Correlation between histological subtypes of 294 endometrial cancers and FIGO stage (S2); Overlapping upregulated/downregulated genes between Kyoto University Microarray data and TCGA_UCEC-2013 (S3); Significantly differentially expressed genes in GSE56026 from comparison of serous-like versus endometrioid-like clusters by SAM analysis (S4); Multivariate analysis of tumor stage, histology subtype and STAT1 with regard to patients' survival (S5); Connectivity Map analysis for potential candidate drugs based on STAT1 pathway gene expression (S6).
Supplementary Tables 1 - 4 from Rapamycin Rescues ABT-737 Efficacy in Small Cell Lung Cancer
Authors: Gardner Eric E. , Connis Nick , Poirier John T. , Cope Leslie , Dobromilskaya Irina , Gallia Gary L. , Rudin Charles M. , Hann Christine L.
Published: March 2023

XLSX file - 138KB, Supplemental Table 1. Tumor sample information, ABT-737 versus vehicle tumors submitted for microarray analysis. Supplemental Table 2. ABT-737 Treatment Response - Differentially Expressed Genes. Supplemental Table 3. ABT-737 Treatment Response - Gene Sets. Supplemental Table 4. Connectivity Map output ranked list.
Supplemental Table S1 from H3K9 Histone Methyltransferase, KMT1E/SETDB1, Cooperates with the SMAD2/3 Pathway to Suppress Lung Cancer Metastasis
Authors: Wu Pei-Chun , Lu Jeng-Wei , Yang Jer-Yen , Lin I-Hsuan , Ou Da-Liang , Lin Yu-Hsiang , Chou Kuan-Hsien , Huang Wen-Feng , Wang Wan-Ping , Huang Yih-Leh , Hsu Chiun , Lin Liang-In , Lin Yueh-Min , Shen C.-K. James , Tzeng Tsai-Yu
Published: March 2023

KMT1E expression in 192 lung cancer as evaluated by tissue microarray-based immunohistochemistry
Supplementary Tables S1-S8 from Targeting the c-Met/FZD8 Signaling Axis Eliminates Patient-Derived Cancer Stem–like Cells in Head and Neck Squamous Carcinomas
Authors: Sun Shuyang , Liu Suling , Duan Sheng Zhong , Zhang Lei , Zhou Henghua , Hu Yongjie , Zhou Xianghui , Shi Chaoji , Zhou Rong , Zhang Zhiyuan
Published: March 2023

Supplementary Tables S1-S8. Clinical and pathologic characteristics of SCCHN patients ; Tumorigenicity of sorted primary SCCHN cells using c-Met and CD44 markers ; The effects of c-Met knockdown on the tumor-initiating capacity of HN-CSCs ; The secondary tumor-initiating ability of cells obtained from the xenografts treated with the indicated agents ; The tumor-initiating capacity of HN-CSCs with Axin or DKK-1 overexpression ; Tumor-initiating ability of HN-CSCs with different treatments ; The target sequence of shRNAs ; Primer sequences for qPCR analyses .
Supplementary Figure 2 from hMOB3 Modulates MST1 Apoptotic Signaling and Supports Tumor Growth in Glioblastoma Multiforme
Authors: Tang Fengyuan , Zhang Lei , Xue Gongda , Hynx Debby , Wang Yuhua , Cron Peter D. , Hundsrucker Christian , Hergovich Alexander , Frank Stephan , Hemmings Brian A. , Schmitz-Rohmer Debora
Published: March 2023

PDF file - 323KB, Supplemental Figure 2. hMOB3 specifically interacts with MST1.
Supplementary Figure 5 from GPER Mediates Activation of HIF1α/VEGF Signaling by Estrogens
Authors: De Francesco Ernestina Marianna , Pellegrino Michele , Santolla Maria Francesca , Lappano Rosamaria , Ricchio Emilia , Abonante Sergio , Maggiolini Marcello
Published: March 2023

PDF file - 19KB, Supplementary Figure S5: HIF-1alpha is involved in the transactivation of VEGF promoter sequence by E2 and G-1.
Supplementary Figure 1 from hMOB3 Modulates MST1 Apoptotic Signaling and Supports Tumor Growth in Glioblastoma Multiforme
Authors: Tang Fengyuan , Zhang Lei , Xue Gongda , Hynx Debby , Wang Yuhua , Cron Peter D. , Hundsrucker Christian , Hergovich Alexander , Frank Stephan , Hemmings Brian A. , Schmitz-Rohmer Debora
Published: March 2023

PDF file - 500KB, Supplemental Figure 1. Upregulation of hMOB3 in GBM and characterization of hMOB3 antibody and shRNAs.
Supplemental Table 1 from Adenosine A2A Receptors Intrinsically Regulate CD8+ T Cells in the Tumor Microenvironment
Authors: Cekic Caglar , Linden Joel
Published: March 2023

Table summarizing the sources, properties and dilutions of antibodies used in this study.
Supplemental Figure 1 from Adenosine A2A Receptors Intrinsically Regulate CD8+ T Cells in the Tumor Microenvironment
Authors: Cekic Caglar , Linden Joel
Published: March 2023

Supplementary Figure 1. Phenotypic analysis of myeloid dendritic cells isolated from spleen (SPL) and B16F10 tumors.
Supplementary Table 1 from Emergence, Involution, and Progression to Carcinoma of Mutant Clones in Normal Endometrial Tissues
Authors: Mutter George L. , Monte Nicolas M. , Neuberg Donna , Ferenczy Alex , Eng Charis
Published: March 2023

PDF file - 14KB, Supplementary Table 1. Mutation List for Pairmax paired protein null samples n = 31.
Supplemental Methods from NQO1 Suppresses NF-κB–p300 Interaction to Regulate Inflammatory Mediators Associated with Prostate Tumorigenesis
Authors: Thapa Dinesh , Meng Peng , Bedolla Roble G. , Reddick Robert L. , Kumar Addanki P. , Ghosh Rita
Published: March 2023

This file contains detailed methods for publication as supplementary information.
Supplementary Table 3 from No Causal Association Identified for Human Papillomavirus Infections in Lung Cancer
Authors: Anantharaman Devasena , Gheit Tarik , Waterboer Tim , Halec Gordana , Carreira Christine , Abedi-Ardekani Behnoush , McKay-Chopin Sandrine , Zaridze David , Mukeria Anush , Szeszenia-Dabrowska Neonila , Lissowska Jolanta , Mates Dana , Janout Vladimir , Foretova Lenka , Bencko Vladimir , Rudnai Peter , Fabianova Eleonora , Tjønneland Anne , Travis Ruth C. , Boeing Heiner , Quirós J. Ramón , Johansson Mikael , Krogh Vittorio , Bueno-de-Mesquita H. Bas , Kotanidou Anastasia , Clavel-Chapelon Françoise , Weiderpass Elisabete , Johansson Mattias , Pawlita Michael , Scelo Ghislaine , Tommasino Massimo , Brennan Paul
Published: March 2023

PDF file - 52KB, Comparison of HPV16 DNA positivity by sex, smoking status and lung histology.
Supplementary Table S4 from GPx2 Suppression of H2O2 Stress Links the Formation of Differentiated Tumor Mass to Metastatic Capacity in Colorectal Cancer
Authors: Emmink Benjamin L. , Laoukili Jamila , Kipp Anna P. , Koster Jan , Govaert Klaas M. , Fatrai Szabolcs , Verheem Andre , Steller Ernst J.A. , Brigelius-Flohé Regina , Jimenez Connie R. , Borel Rinkes Inne H.M. , Kranenburg Onno
Published: March 2023

Supplementary Table S4. The epithelial signature.
Supplementary Table of Antibodies from Myeloid Expression of Adenosine A2A Receptor Suppresses T and NK Cell Responses in the Solid Tumor Microenvironment
Authors: Cekic Caglar , Day Yuan-Ji , Sag Duygu , Linden Joel
Published: March 2023

Supplementary Table of Antibodies.
Supplementary Figure Legends from Myeloid Expression of Adenosine A2A Receptor Suppresses T and NK Cell Responses in the Solid Tumor Microenvironment
Authors: Cekic Caglar , Day Yuan-Ji , Sag Duygu , Linden Joel
Published: March 2023

Supplementary Figure Legends. Legends for supplementary Figures 1 and 2.
Supplementary Materials and Methods from GPx2 Suppression of H2O2 Stress Links the Formation of Differentiated Tumor Mass to Metastatic Capacity in Colorectal Cancer
Authors: Emmink Benjamin L. , Laoukili Jamila , Kipp Anna P. , Koster Jan , Govaert Klaas M. , Fatrai Szabolcs , Verheem Andre , Steller Ernst J.A. , Brigelius-Flohé Regina , Jimenez Connie R. , Borel Rinkes Inne H.M. , Kranenburg Onno
Published: March 2023

Supplementary Materials and Methods. Description of additional methods and procedures used in the study.
Supplementary Figure S6 from GPx2 Suppression of H2O2 Stress Links the Formation of Differentiated Tumor Mass to Metastatic Capacity in Colorectal Cancer
Authors: Emmink Benjamin L. , Laoukili Jamila , Kipp Anna P. , Koster Jan , Govaert Klaas M. , Fatrai Szabolcs , Verheem Andre , Steller Ernst J.A. , Brigelius-Flohé Regina , Jimenez Connie R. , Borel Rinkes Inne H.M. , Kranenburg Onno
Published: March 2023

Supplementary Figure S6. High GPx2 expression in CCS3 subtype colon tumors is associated with increased metastatic risk.
Supplementary Figure S5 from GPx2 Suppression of H2O2 Stress Links the Formation of Differentiated Tumor Mass to Metastatic Capacity in Colorectal Cancer
Authors: Emmink Benjamin L. , Laoukili Jamila , Kipp Anna P. , Koster Jan , Govaert Klaas M. , Fatrai Szabolcs , Verheem Andre , Steller Ernst J.A. , Brigelius-Flohé Regina , Jimenez Connie R. , Borel Rinkes Inne H.M. , Kranenburg Onno
Published: March 2023

Supplementary Figure S5. GPx2 expression in human colon tumor cohorts correlates with epithelial differentiation and low H2O2 stress.
Supplementary Figure S4 from GPx2 Suppression of H2O2 Stress Links the Formation of Differentiated Tumor Mass to Metastatic Capacity in Colorectal Cancer
Authors: Emmink Benjamin L. , Laoukili Jamila , Kipp Anna P. , Koster Jan , Govaert Klaas M. , Fatrai Szabolcs , Verheem Andre , Steller Ernst J.A. , Brigelius-Flohé Regina , Jimenez Connie R. , Borel Rinkes Inne H.M. , Kranenburg Onno
Published: March 2023

Supplementary Figure S4. Overexpression of GPx2 promotes differentiation of CSCs and accelerates tumor growth.
Supplementary Figure 5. Influence analysis from Ceramide Kinase Promotes Tumor Cell Survival and Mammary Tumor Recurrence
Authors: Payne Ania W. , Pant Dhruv K. , Pan Tien-Chi , Chodosh Lewis A.
Published: March 2023

Influence analyses were performed on all significant p-values derived by meta-analysis to determine whether the significant result was independent of any single dataset.
Supplementary Figure 3. CERK expression in human breast cancer subsets from Ceramide Kinase Promotes Tumor Cell Survival and Mammary Tumor Recurrence
Authors: Payne Ania W. , Pant Dhruv K. , Pan Tien-Chi , Chodosh Lewis A.
Published: March 2023

Association between CERK mRNA expression and (A) ER status, (B) PR status, (C) HER2 status, (D) molecular subtype and (E) tumor grade in pooled datasets of human breast cancer patients. Each variable was analyzed by ANOVA.
Supplementary Figure 1. Ki67 staining and Western blots from Ceramide Kinase Promotes Tumor Cell Survival and Mammary Tumor Recurrence
Authors: Payne Ania W. , Pant Dhruv K. , Pan Tien-Chi , Chodosh Lewis A.
Published: March 2023

(A) Quantification of MTB/TAN primary tumor cell lines expressing pk1, Cerk or G198D- Cerk withdrawn from doxycycline 72 hr then stained for Ki67. (B) Quantification of MTB/TAN primary tumor cell lines expressing MLP, a control scrambled shRNA, shCerk1 or shCerk2 withdrawn from doxycycline 72 hr then stained for Ki67. (C) Western blot of MTB/TAN primary tumor cell lines expressing empty vector, a control scrambled shRNA, or shCerk1 withdrawn from doxycycline 48 hr, blotted for cleaved PARP, quantified in (D), and cleaved caspase-3, quantified in (E).
Supplemental Methods from Preclinical Activity of Nanoliposomal Irinotecan Is Governed by Tumor Deposition and Intratumor Prodrug Conversion
Authors: Kalra Ashish V. , Kim Jaeyeon , Klinz Stephan G. , Paz Nancy , Cain Jason , Drummond Daryl C. , Nielsen Ulrik B. , Fitzgerald Jonathan B.
Published: March 2023

Supplemental Methods. This document contains information on pharmacokinetic model development
Supplementary Figure 7 from Targeting the MYC and PI3K Pathways Eliminates Leukemia-Initiating Cells in T-cell Acute Lymphoblastic Leukemia
Authors: Schubbert Suzanne , Cardenas Anjelica , Chen Harrison , Garcia Consuelo , Guo Wei , Bradner James , Wu Hong
Published: March 2023

DN thymocytes (DN3 and DN4) show highest levels of c-Myc in comparison to DP and SP populations.
Supplementary Figure 6 from Targeting the MYC and PI3K Pathways Eliminates Leukemia-Initiating Cells in T-cell Acute Lymphoblastic Leukemia
Authors: Schubbert Suzanne , Cardenas Anjelica , Chen Harrison , Garcia Consuelo , Guo Wei , Bradner James , Wu Hong
Published: March 2023

Pten null T-ALL blasts show lower levels of phospho-AKT in response to JQ1 in comparison to LICs.
Data Supplement from Macrophage Inflammatory Protein Derivative ECI301 Enhances the Alarmin-Associated Abscopal Benefits of Tumor Radiotherapy
Authors: Kanegasaki Shiro , Matsushima Kouji , Shiraishi Kenshiro , Nakagawa Keiichi , Tsuchiya Tomoko
Published: March 2023

Supplementary Fig. 1. Effect of iv-administered mixture of ECI301/HSP60 (A), ECI301/HSP70 or ECI301/HSP90 (B), and ECI301/HSP70 or hMIP-1Î±/HSP70 (C) on tumor growth Colon26 cells (4x105 cell/mouse) were implanted in the right flank of BALB/c mice. When the tumor size reached 5-10 mm diameter (14 days), animals received each mixture at the indicated amount (Î¼g), intravenously 3 times at days 0, 1 and 2. The average tumor volumes {plus minus} SE (n=7 or 8) at day 13 are shown. Tumor growth without any treatment is shown as Control. In B, the units of numbers in parenthesis are Î¼g. Under similar conditions as A, a statistically significant anti-tumor effect was found with a mixture of ECI301/HSP70 but not with ECI301/ HSP60 (each 2/0.5 Î¼g/mouse). Significant differences are indicated by: **, p< 0.01 or *, p< 0.05 (Dunnet). Supplementary Fig. 2. Number of splenocytes with IFN-ï�§ generating potential in tumor-bearing mice ELISPOT assay was performed using erythrocyte-depleted splenocytes from tumor bearing miceï¼ŽLLC cells (4 x 105 cells) were inoculated in the right flank of C57BL/6 mice and 18 days after inoculation, the local tumor growing area was exposed to radiation. ECI301 was administered 20 h after irradiation. Splenocytes were obtained from the mice bearing LLC cells 4 days after irradiation (3 days after ECI301 administration). The splenocytes and those from age-matched naÃ¯ve mice (each 5 x 104) were placed into 96-well plates of the ELISPOT assay kit (MabTeck AB Co., Stockholm, Sweden) and incubated at 37 ÂºC for 20 h under 5% CO2, in the presence or absenceã€€ï¼ˆControlï¼‰ of mitomycin C-treated LLCï¼ˆLLCï¼‰ or MethA tumor cells (MethA, each 5 x 103 cells). ELISPOT assays were performed according to the company's instructions and the number of cells that capable of generating IFN-Î³ was determined. The mean number of spots per 5 x 104 splenocytes {plus minus} SE are shown. Significant differences from the control group are indicated by: ** p<0.01 (ANOVA). Significant differences from the control group or irradiated group are indicated by: # p<0.05 (Student's t-test). ## p<0.01 (t-test). n=4.
Supplementary Figure 5 from Targeting the MYC and PI3K Pathways Eliminates Leukemia-Initiating Cells in T-cell Acute Lymphoblastic Leukemia
Authors: Schubbert Suzanne , Cardenas Anjelica , Chen Harrison , Garcia Consuelo , Guo Wei , Bradner James , Wu Hong
Published: March 2023

Primary human pediatric T-ALL samples show elevated levels of phospho-AKT.
Data Supplement from HSV-sr39TK Positron Emission Tomography and Suicide Gene Elimination of Human Hematopoietic Stem Cells and Their Progeny in Humanized Mice
Authors: Gschweng Eric H. , McCracken Melissa N. , Kaufman Michael L. , Ho Michelle , Hollis Roger P. , Wang Xiaoyan , Saini Navdeep , Koya Richard C. , Chodon Thinle , Ribas Antoni , Witte Owen N. , Kohn Donald B.
Published: March 2023

Supplementary Table S1. Total human chimerism and lymphoid composition in NSG recipients of ESO/TK-transduced or non-transduced PBSC.
Data Supplement from HSV-sr39TK Positron Emission Tomography and Suicide Gene Elimination of Human Hematopoietic Stem Cells and Their Progeny in Humanized Mice
Authors: Gschweng Eric H. , McCracken Melissa N. , Kaufman Michael L. , Ho Michelle , Hollis Roger P. , Wang Xiaoyan , Saini Navdeep , Koya Richard C. , Chodon Thinle , Ribas Antoni , Witte Owen N. , Kohn Donald B.
Published: March 2023

Description of additional methods and procedures used in the study. Also includes supplemental references.
Data Supplement from HSV-sr39TK Positron Emission Tomography and Suicide Gene Elimination of Human Hematopoietic Stem Cells and Their Progeny in Humanized Mice
Authors: Gschweng Eric H. , McCracken Melissa N. , Kaufman Michael L. , Ho Michelle , Hollis Roger P. , Wang Xiaoyan , Saini Navdeep , Koya Richard C. , Chodon Thinle , Ribas Antoni , Witte Owen N. , Kohn Donald B.
Published: March 2023

Legend for Supplemental Figures S1-S3.
Supplementary Movie 2C from mTOR Signaling Feedback Modulates Mammary Epithelial Differentiation and Restrains Invasion Downstream of PTEN Loss
Authors: Ghosh Susmita , Varela Lidenys , Sood Akshay , Park Ben Ho , Lotan Tamara L.
Published: March 2023

MOV - 1654 KB, Acinar morphogenesis in PTEN-/- MCF10A cells treated with rapamycin reveals abundant, stabilized invasive protrusions into ECM. 54-hour time-lapse DIC imaging (roughly days 1-3 after plating) of PTEN-/- MCF10A clone #1 treated with rapamycin (200 nM). Invasive cytoplasmic protrusions into surrounding collagen-Matrigel ECM are evident from the beginning and fail to retract, forming a web of interconnected ducts with cell migration and proliferation.