bluuebunny/crossref_metadata_2025 huggingface dataset:
Analysis of Stable Chelate-free Gadolinium Loaded Titanium Dioxide
Nanoparticles for MRI-Guided Radionuclide Stimulated Cancer Treatment
Authors: Fang Lei , Huang Hengbo , Quirk James D. , Zheng Jie , Shen Duanwen , Manion Brad , Mixdorf Matthew , Karmakar Partha , Sudlow Gail P. , Tang Rui , Achilefu Samuel
Published: March 2022

Background:

Recent studies demonstrate that titanium dioxide nanoparticles (TiO2 NPs) are an
effective source of reactive oxygen species (ROS) for photodynamic therapy and radionuclide stimulated
dynamic therapy (RaST). Unfortunately, tracking the in vivo distribution of TiO2 NPs noninvasively
remains elusive.

Objective:

Given the use of gadolinium (Gd) chelates as effective contrast agents for magnetic resonance
imaging (MRI), this study aims to (1) develop hybrid TiO2-Gd NPs that exhibit high relaxivity for tracking
the NPs without loss of ROS generating capacity; and (2) establish a simple colorimetric assay for
quantifying Gd loading and stability.

Method:

A chelate-free, heat-induced method was used to load Gd onto TiO2 NPs, which was coated with
transferrin (Tf). A sensitive colorimetric assay and inductively coupled plasma mass spectrometry (ICP-MS)
were used to determine Gd loading and stability of the TiO2-Gd-Tf NPs. Measurement of the relaxivity was
performed on a 1.4 T relaxometer and a 4.7 T small animal magnetic resonance scanner to estimate the effects
of magnetic field strength. ROS was quantified by activated dichlorodihydrofluorescein diacetate fluorescence.
Cell uptake of the NPs and RaST were monitored by fluorescence microscopy. Both 3 T and 4.7 T
scanners were used to image the in vivo distribution of intravenously injected NPs in tumor-bearing mice.

Results:

A simple colorimetric assay accurately determined both the loading and stability of the NPs
compared with the expensive and complex ICP-MS method. Coating of the TiO2-Gd NPs with Tf stabilized
the nanoconstruct and minimized aggregation. The TiO2-Gd-Tf maintained ROS-generating capability
without inducing cell death at a wide range of concentrations but induced significant cell death under
RaST conditions in the presence of F-18 radiolabeled 2-fluorodeoxyglucose. The longitudinal (r1 = 10.43
mM-1s-1) and transverse (r2 = 13.43 mM-1s-1) relaxivity of TiO2-Gd-Tf NPs were about twice and thrice,
respectively, those of clinically used Gd contrast agent (Gd-DTPA; r1 = 3.77 mM-1s-1 and r2 = 5.51 mM-1s-1)
at 1.4 T. While the r1 (8.13 mM-1s-1) reduced to about twice that of Gd-DTPA (4.89 mM-1s-1) at 4.7 T, the
corresponding r2 (87.15 mM-1s-1) increased by a factor 22.6 compared to Gd-DTPA (r2 = 3.85). MRI of
tumor-bearing mice injected with TiO2-Gd-Tf NPs tracked the NPs distribution and accumulation in tumors.

Conclusion:

This work demonstrates that Arsenazo III colorimetric assay can substitute ICP-MS for determining
the loading and stability of Gd-doped TiO2 NPs. The new nanoconstruct enabled RaST effect in
cells, exhibited high relaxivity, and enhanced MRI contrast in tumors in vivo, paving the way for in vivo
MRI-guided RaST.
A Focused Review on Molecular Signalling Mechanisms of Ginsenosides Anti-Lung
Cancer and Anti-inflammatory Activities
Authors: Yang Deok-Chun , Kang Se Chan , Jung Dae-Hyo , Nahar Jinnatun , Mathiyalagan Ramya , Rupa Esrat Jahan , Ramadhania Zelika Mega , Han Yaxi
Published: March 2022

Background:

Ginseng (Panax ginseng Meyer) is a cultivated medicinal herb that has been widely available
in the Asian region since the last century. Ginseng root is used worldwide in Oriental medicine. Currently, the global
mortality and infection rates for lung cancer and inflammation are significantly increasing. Therefore, various preventative
methods related to the activity of ginsenosides have been used for lung cancer as well as inflammation.

Methods:

Web-based searches were performed on Web of Science, Springer, PubMed, and Scopus. A cancer statistical
analysis was also conducted to show the current ratio of affected cases and death from lung cancer around the world.

Results:

Ginsenosides regulate the enzymes that participate in tumor growth and migration, such as nuclear factor
kappa B (NF-κB), mitogen-activated protein kinase (p38 MAPK), c-Jun N-terminal kinase (JNK), extracellular signalregulated
kinases 1/2 (ERK1/2), the gelatinase network metalloproteinase-2 (MMP-2/9) and activator protein 1 (AP-1).
In addition, ginsenosides also possess anti-inflammatory effects by inhibiting the formation of proinflammatory cytokines
(tumor necrosis factor-α) (TNF-α) and interleukin-1β (IL-1β) and controlling the activities of inflammatory
signalling pathways, such as NF-κB, Janus kinase2/signal transducer, and activator of transcription 3 (Jak2/Stat3).

Conclusion:

In several in vitro and in vivo models, P. ginseng showed potential beneficial effects in lung cancer and
inflammation treatment. In this review, we provide a detailed and up-to-date summary of research evidence for antilung
cancer and anti-inflammatory protective effects of ginsenosides and their potential molecular mechanisms.
lncRNA H22954 Inhibits Angiogenesis in Acute Myeloid Leukemia through
a PDGFA-dependent Mechanism
Authors: Li Xuewei , Rong Jianjie , Li Tianyu , Zhou Yujing , Qi Xiaofei
Published: March 2022

Background:

Angiogenesis is a hallmark of cancer, which is regulated by diverse factors, including long non-coding RNAs (lncRNAS). Our previous study showed that the long non-coding RNA H22954 inhibits tumor growth, albeit whether it is involved in the angiogenesis of cancer re-mains unknown.

Objectives:

This study aimed to investigate the role of lncRNA H22954 in angiogenesis of acute myeloid leukemia (AML) and the underlying molecular mechanism.

Methods:

Bioinformatics analysis was conducted to screen the targeted molecule of H22954. Western blot and ELISA analysis detected PDGFA protein expression, and RT-qPCR detected H22954 and PDGFA expression in cell lines and AML samples. Dual-luciferase reporter gene assay and half-life assay were applied to validate the relationship between H22954 and PDGFA. The functional experi-ment was conducted to investigate the role of H22954 in tube formation.

Results:

Overexpression of H22954 inhibited angiogenesis in mouse xenograft tumors and cultured acute myeloid leukemia (AML) cells. Bioinformatics analysis and luciferase assay revealed that H22954 targeted the 3’ untranslated region (UTR) of the platelet-derived growth factor subunit A (PDGFA) gene. In transfected cells, H22954 overexpression reduced PDGFA expression and protein levels. Tube formation was rescued following the addition of exogenous human PDGFA to the con-ditioned medium from cells overexpressing H22954. The expression of H22954 in K562 cells re-duced the half-life of PDGFA mRNA. Furthermore, H22954 expression was inversely correlated with PDGFA expression in patient samples.

Conclusion:

These findings indicate that H22954 inhibits angiogenesis in AML through the down-regulation of PDGFA expression. Administering recombinant lncRNA H22954 may be a therapeutic approach for patients with AML.
The Potential Impact of Ayurvedic Traditional Bhasma on SARS-CoV- 2-
Induced Pathogenesis
Authors: Kumar Pankaj , Jayakumar Remya , Dash Manoj Kumar , Joshi Namrata
Published: March 2022

In India, the presently ongoing infectious COVID-19 wave is caused by the delta variant of SARS-CoV-2 which has also led thousands of causalities across the globe. The government and healthcare agencies are hovering for effective strategies to counter the pandemic. The application of nanotechnology and repurposing of drugs are found an effective approach, not obsolete but partly in managing the COVID-19 disease. It has also immensely boomed the search of productive, reliable, cost-effective, and bio-assimilable alternative solutions. Since ancient times, the traditionally employed Ayurvedic bhasmas opted for diverse infectious diseases, which are now justified as a nanomedicine that could be applied for managing COVID-19 related health anomalies. Like currently existing engineered metal nanoparticles (NPs), the bhasma nanoparticles (BNPs) are also packed with unique physicochemical properties including multi-elemental nanocrystalline composition, size, shape, dissolution, surface charge, hydrophobicity, multi-pathway regulatory, and modulatory effects. Here, it is hypothesized that due to these conformational- and configurational- based physicochemical advantages, bhasma NPs might have promising potential to manage the COVID-19 pandemic and can reduce the incidence of pneumonia-like common lung infections in children as well as old-age-related inflammatory diseases by immunomodulatory, anti-inflammatory, antiviral, and adjuvant-related characteristics.
An Overview of Flavonoids: A Diverse Group of Bioactive Phytoconstituents
Authors: Arora Vimal , Sharma Navni , Tarique Mohammad , Vyas Govind , Sharma R.B.
Published: March 2022

Background:

Flavonoids are phenolic compounds or plant constituents containing phenol
ring and is also known as a polyphenolic compound. Flavonoids have remarkable antioxidant potential,
but along with this, they also exhibit a variety of activities through various mechanisms. Flavonoids
are classified into six different groups based on their chemical structures and these activities
are owed to six different basic structures. In this manuscript, the focus has been paid to two subclasses
i.e, Flavonoids and flavanols.

Objective:

The aim of this review is to highlight the potential of flavonoids in the treatment of various
ailments and prospects associated with the delivery of flavonoids.

Methods:

We reviewed the literature from journal publication websites and electronic databases,
such as Bentham, Springer, Science Direct, PubMed, Scopus, etc.

Results:

The abundant availability of sources of flavonoids makes a point in favour of exhaustive
exploration of this group. Herbals having a high content of flavonoids have been used in the treatment
of a number of ailments from ancient times by human beings and these are reported to be having
anti-bacterial, anti-fungal, anti-viral, anti-inflammatory, anti-cancer, antihyperglycemic, and antioxidant
potential.

Conclusion:

There are a number of health benefits of flavonoids that makes this group of bioactive
compounds the most promising and attractive group for researchers. The need of the hour is to explore
more efficient extraction processes and advanced delivery systems for such an active and
widely distributed class of natural compounds.
The CURAT Sonification Game: Gamification for Remote Sonification Evaluation
Authors: Ziemer Tim , Schultheis Holger
Published: March 2022

As sonification is supposed to communicate information to users, experimental evaluation of the subjective appropriateness and effectiveness of the sonification design is often desired and sometimes indispensable. Experiments in the laboratory are typically restricted to short-term usage by a small sample size under unnatural conditions. We introduce the multi-platform CURAT Sonification Game that allows us to evaluate our sonification design by a large population during long-term usage. Gamification is used to motivate users to interact with the sonification regularly and conscientiously over a long period of time. In this paper we present the sonification game and some initial analyses of the gathered data. Furthermore, we hope to reach more volunteers to play the CURAT Sonification Game and help us evaluate and optimize our psychoacoustic sonification design and provide feedback on the game and recommendations for future developments.
Network Sonification and the Algorhythmics of Everyday Life
Authors: El Hajj Tracey
Published: March 2022

Today, public concern with the extent to which they influence people’s routines, and how much they affect cultures and societies, has grown substantially. This paper argues that, by listening to networks, people can begin to apprehend, and even comprehend, the complex, ostensibly “magical” nature of network communications. One problem is that listening semantically to networks is incredibly difficult, if not impossible. Networks are very noisy, and they do not, for instance, use alphabetic language for internal or external communication. For the purpose of interpreting networks, I propose “tactical network sonification” (TNS), a technique that focuses on making the materiality of networks sensibly accessible to the general public, especially people who are not technology experts. Using an electromagnetic transduction device—Shintaro Miyazaki and Martin Howse’s Detektor—TNS results in crowded sound clips that represent the complexity of network infrastructure, through the many overlapping rhythms and layers of sound that each clip contains.
Auditory Graphs from Denoising Real Images Using Fully Symmetric Convolutional Neural Networks
Authors: Cádiz Rodrigo F. , Droppelmann Lothar , Guzmán Max , Tejos Cristian
Published: March 2022

Auditory graphs are a very useful way to deliver numerical information to visually impaired users. Several tools have been proposed for chart data sonification, including audible spreadsheets, custom interfaces, interactive tools and automatic models. In the case of the latter, most of these models are aimed towards the extraction of contextual information and not many solutions have been proposed for the generation of an auditory graph directly from the pixels of an image by the automatic extraction of the underlying data. These kind of tools can dramatically augment the availability and usability of auditory graphs for the visually impaired community. We propose a deep learning-based approach for the generation of an automatic sonification of an image containing a bar or a line chart using only pixel information. In particular, we took a denoising approach to this problem, based on a fully symmetric convolutional neural network architecture. Our results show that this approach works as a basis for the automatic sonification of charts directly from the information contained in the pixels of an image.
Dreamsound: Deep Activation Layer Sonification
Authors: Halac Federico Nicolás Cámara , Delgadino Matías
Published: March 2022

Deep learning (DL) in audio signal processing has received much attention in the last four years, and it is still a growing field. Some attempts were made to translate deep networks from image to audio applications, and we discuss some of the issues that arise. In the present paper, we present DreamSound, a creative adaptation of Deep Dream to sound addressed from two approaches: input manipulation, and sonification design. Our chosen model is YAMNet, a pre-trained deep network for sound classification. We present the original Deep Dream activation maximization function in relation to three filter-based creative variations that were implemented. We find that more interesting results are achieved with this filter-based approach, but that there is still room for experimentation.
The Sound of Our Words: Singling, a Textual Sonification Software
Authors: Morales Esteban , James Kedrick , Horst Rachel , Takeda Yuya , Yung Effiam
Published: March 2022

As visualization struggles to grasp the intricate and temporal networks of meaning found in textual data, sonification emerges as a creative and effective way of representing language. Accordingly, this paper seeks to introduce Singling, a textual sonification software that allows users to create and manipulate auditory representations of a text's lexicogrammatical properties. To achieve this, we first present Singling's main features and interface. We then discuss an example of using this sonification software to explore—both analytically and aesthetically—three different poems. Overall, this paper seeks to introduce researchers, educators, and artists to the many possibilities of Singling and the practice of textual sonification, which includes data analysis, multimodal and collaborative narrative creation, and musical performance to name a few.
Perceptually-Motivated Sonification of Spatiotemporally-Dynamic CFD Data
Authors: Temor Lucas , MacDonald Daniel E. , Natarajan Thangam , Coppin Peter W. , Steinman David A.
Published: March 2022

Everyday perception and action are fundamentally multisensory. Despite this, the sole reliance on visualization for the representation of complex 3D spatiotemporal data is still widespread. In the past we have proposed various prototypes for the sonification of dense data from computational fluid dynamics (CFD) simulations of turbulent-like blood flow, but did not robustly consider the perception and associated meaning-making of the resultant sounds. To reduce some of the complexities of these data for sonification, in this work we present a feature-based approach, applying ideas from auditory scene analysis to sonify different data features along perceptually-separable auditory streams. As there are many possible features in these dense data, we followed the analogy of “caricature” to guide our definition and subsequent amplification of unique spectral and fluctuating features, while effectively minimizing the features common between simulations. This approach may allow for better insight into the behavior of flow instabilities when compared to our previous sonifications and/or visualizations, and additionally we observed benefits when some redundancy was maintained between modalities.
SIREN: A Case Study in Web Audio Based Sonification
Authors: Peng Tristan , Choi Hongchan
Published: March 2022

SIREN is an open-source, web-based sonification workstation that provides an accessible entry point to data mapping sonification and aims to demonstrate a use case for the Web Audio API. With plug-and-play functionality, and numerous methods to customize and create meaningful auditory display, SIREN provides useful features for pedagogy, methods for exploratory data sonification, and an extensible, open-ended development platform. Inspired by common digital audio workstation (DAW) workflows, SIREN provides a familiar and intuitive layout based upon data matrices as tracks that can be chained together as channels, thus allowing values in one data sequence to control a parameter of another data array. This paper describes the application’s design philosophy and provides a case study as usage examples. We place the program in a comparative context with other data-mapping front-ends, and describe future goals.
Panoptic Reconstruction of Immersive Virtual Soundscapes Using Human-Scale Panoramic Imagery with Visual Recognition
Authors: Huang Mincong (Jerry) , Chabot Samuel , Braasch Jonas
Published: March 2022

This work, situated at Rensselaer’s Collaborative-Research Augmented Immersive Virtual Environment Laboratory (CRAIVE-Lab), uses panoramic image datasets for spatial audio display. A system is developed for the room-centered immersive virtual reality facility to analyze panoramic images on a segment-by-segment basis, using pre-trained neural network models for semantic segmentation and object detection, thereby generating audio objects with respective spatial locations. These audio objects are then mapped with a series of synthetic and recorded audio datasets and populated within a spatial audio environment as virtual sound sources. The resulting audiovisual outcomes are then displayed using the facility’s human-scale panoramic display, as well as the 128-channel loudspeaker array for wave field synthesis (WFS). Performance evaluation indicates effectiveness for real-time enhancements, with potentials for large-scale expansion and rapid deployment in dynamic immersive virtual environments.
To Sonify or Not to Sonify? Educator Perceptions of Auditory Display in Interactive Simulations
Authors: Fiedler Brett L. , Walker Bruce N. , Moore Emily B.
Published: March 2022

With the growing presence of auditory display in popular learning tools, it is beneficial to researchers to consider not only the perceptions of the students who use the tools, but the educators who include the tools in their curriculum. We surveyed over 4000 educators to investigate educator perceptions and preferences across four interactive physics simulations for the presence and qualities of non-speech auditory display, as well as surveying users’ self-rated musical sophistication as potentially predictive of auditory display preference. We find that the majority of teachers preferred the simulations with auditory display and consistently rated aspects of the experience using simulations with sound positively over the without-sound variants. We also identify simulation design features that align with trends in educator ratings. We did not find the measured musical sophistication to be a predictor of auditory display preference.
Features of age-related changes in the skin in people living near uranium tailings in mountains
Authors:   Kyrgyz-Russian Slavic University, Kyrgyz State Medical Academy, Bishkek, Isupova A.A.
Published: March 2022

The work touches upon the issue of long-term influence (more than 50 years) of low doses of ra-diation on the condition of the skin. The role of long-term incoming radionuclides into the internal environment of the body on the development of age-related changes in the skin in people living near uranium tailings in mountainous conditions has been studied. 355 indigenous people of Kyrgyzstan were examined. Of these, 62 (17.5%) people were withdrawn from the study according to the exclusion criteria. The sample consisted of 293 people. The main group consisted of 75 people, including 45 (60%) women and 30 (40%) men, mean age 38.7+/-14.7 (95% CI 35.3-42.1) years. The control group consisted of 218 people, of which 99 (45.4%) were men and 119 (54.6%) were women. Age range from 17 to 77 years. Clinical studies were carried out according to the generally accepted methodology. Differential diagnosis of skin neoplasms was carried out using a Heine Delta 20 dermatoscope (K-256.27.376, Heine Optotechnik, Germany). Statistical analysis was performed using PASW Statistics 21.0 (SPSS Inc., IBM, Chicago, USA). To assess the effect of a risk factor, the attributable risk, risk ratio, and potential harm index (NNT) were cal-culated, and a 95% confidence interval was calculated for each variable. Statistical analysis of clinical and epidemiological data made it possible to identify a number of geriatric signs to as-sess the influence of a risk factor on age-related changes in the skin. The additional risk of age-related skin changes varies from 37+/-2.82% (95% CI 31.5-42.5%) to 63.2+/-2.81 (95% CI 57.7-68.7 %) compared with the control group. The degree of sensitivity of geriatric stigmas to the risk factor is different. At the same time, the relative contribution of the risk factor can be assessed by the severity of the frequency of occurrence of geriatric signs in people living in the zone of radioac-tive waste disposal in comparison with residents of conditionally "clean" living areas.
Циркулярно-поляризованная электролюминесценция спиновых светоизлучающих диодов InGaAs/GaAs/CoPt, помещенных в сильное и слабое магнитное поле
Authors: Дорохин М.В. , Демина П.Б. , Здоровейщев А.В. , Зайцев С.В. , Кудрин А.В.
Published: March 2022

A comparative study of the circular polarization degree dependences on external magnetic field was carried out in spin light-emitting diodes including semiconductor InGaAs/GaAs heterostructure and a magnetic CoPt contact and in control non-magnetic structures with an Au contact. In a weak magnetic field, the magnetic field dependence of electroluminescence circular polarization degree is similar to the magnetic field dependence of magnetization: it represents a hysteresis loop with saturation in a field of ~ 0.3 T. In a strong magnetic field, an additional linear contribution to the circular polarization degree is detected. This contribution is associated with the Zeeman splitting of energy levels. The magnitude of the linear contribution depends on the position of the quantum well relative to the ferromagnet/semiconductor interface. The obtained dependence is associated with the influence of the magnetic field of the inhomogeneously magnetized CoPt electrode on the spin relaxation time of carriers.
An Intelligent and Precise Method Used for Detecting Gestational Diabetes in the Early Stages
Authors: Hameed Safa , Ali Alaa Badeea
Published: March 2022

This paper suggests a Naive Bayes classifier technique for identifying and categorizing gestational diabetes mellitus (GDM), GDM is a kind of diabetes mellitus that affects a small proportion of pregnant women but recovers to normal once the baby is born. The Pima Indians Diabetes Dataset was chosen for a comprehensive analysis of this critical and pervasive health disease because it contains 768 patient characteristics acquired from a machine learning source at the University of California, Irvine. The goal of the study is to apply smart technology to categorize diseases with high accuracy and precision, practically free of conceivable and potential faults, to provide satisfying findings. The approach is based on eight major characteristics that are present in the operations that are required to establish a precise and reliable categorization system. This approach involves training and testing on real data, as well as for deciding whether or not to construct a categorization model. The work was compared to earlier work and had a 96% accuracy rating.
A Mobile Phone App Intervention to Promote Healthy Salt Intake Among Adults: Protocol for a Randomized Controlled Study (Preprint)
Authors: Perin Milena Sia , São-João Thais , Gallani Maria Cecília Bueno Jayme , Agbadje Titilayo Tatiana , Rodrigues Roberta Cunha Matheus , Cornélio Marilia Estevam
Published: March 2022

BACKGROUND

There is sound evidence associating high salt intake and a greater risk of cardiovascular and noncardiovascular diseases. High salt intake has been observed in several populations worldwide. Therefore, promoting healthier salt consumption has been encouraged as a low-cost strategy to reduce this risk factor. However, these strategies need to be sound, built on theoretical and methodological bases, and consider the target population’s context.

OBJECTIVE

This protocol aims to describe a mobile phone app intervention to promote healthy salt intake among adults.

METHODS

This is an experimental and longitudinal study protocol conducted in three modules. Module 1 refers to the planning of the intervention based on the Behaviour Change Wheel framework. Module 2 is the development of the mobile phone app intervention based on the date of module 1. In module 3, the intervention will be evaluated using a randomized controlled study, with three steps of data collection in a 2-month follow-up in a sample of 86 adults (43 participants for each group: the control group and intervention group) recruited from the primary health care centers of a Brazilian town. The discretionary salt intake questionnaire will assess salt consumption, the app usability will be assessed using the System Usability Scale, and psychosocial variables (habit, intention, and self-efficacy) will also be measured.

RESULTS

Recruitment began in October 2021, and the follow-up will end in August 2022. The results of this study are expected to be published in 2023.

CONCLUSIONS

Results from this study will help people to control salt intake when cooking at home, will stimulate self-care, will work as an alternative or supportive method in the relationship between health care professionals and patients, and will contribute to implementing the app intervention to promote healthy salt intake on a large scale.

CLINICALTRIAL

The Brazilian Clinical Trials Registry RBR-4s8qyyq; https://ensaiosclinicos.gov.br/rg/RBR-4s8qyyq

INTERNATIONAL REGISTERED REPORT

DERR1-10.2196/37853
Psychometric properties of the hospital anxiety and depression scale (HADS) in individuals with chronic obstructive pulmonary disease (COPD): A systematic review protocol (Preprint)
Authors: Alsubheen Sanaa , Rhodenizer Jonathan , Nikolovski Aleksandra , Quilichini Shea , Kazemir Ethan , Gamgoum Lara , Deol Arshpreet , Oliveira Ana , Brooks Dina
Published: March 2022

BACKGROUND

In individuals with Chronic Obstructive Pulmonary Disease (COPD), anxiety and depression contribute to increased mortality and exacerbations, decreased physical functioning, and deteriorated health-related quality of life (HRQoL). The Hospital Anxiety and Depression Scale (HADS) is a patient-reported tool developed to measure symptoms of anxiety and depression in clinical settings. The HADS has been frequently used with individuals with COPD, however, its measurement properties lack critical appraisal in this population.

OBJECTIVE

To summarize and critically appraise the validity, reliability, and responsiveness of the HADS in individuals with COPD.

METHODS

Five electronic databases (MEDLINE, EMBASE, Scopus, PsychINFO, and Web of Science) will be systematically searched. Articles will be included if they assessed the measurement properties of the HADS in COPD, published in a peer-reviewed journal, and written in English, Arabic, Portuguese, or French. The Consensus-based Standards for the Selection of Health Measurement Instruments (COSMIN) guidelines will be used to assess the methodological quality and level of evidence in the selected studies.

RESULTS

The results of the psychometric properties of HADS will be qualitatively summarized and compared against the criteria for good measurement properties. The overall quality of evidence will be graded using the modified Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach.

CONCLUSIONS

This systematic review will be the first to evaluate the psychometric properties of the HADS in individuals with COPD. Given the negative impact of anxiety and depression on physical functioning and HRQoL, this systematic review provides an opportunity to utilize the HADS as a validated measurement tool for the assessment and treatment of anxiety and depression in individuals with COPD.

CLINICALTRIAL

Protocol registration #: Under review with the International Prospective Register of Systematic Reviews (PROSPERO).
The Future of Data, supported by Artificial Intelligence, in the Post-Pandemic World – Challenges and Opportunities for Digital Health Leaders (Preprint)
Authors: Loh Erwin
Published: March 2022

UNSTRUCTURED

The COVID-19 pandemic has changed the way we relate to data. This paper summarises how data has been used during the pandemic, how the use of artificial intelligence (AI) algorithms has been accelerated, and what the post-pandemic future could look like. The pandemic has changed the way we release research data. The confluence of improved wireless connectivity, the rise of wearable sensors with smart internet of things, and the improvements in artificial intelligence (AI), has the potential to transform personalised medicine. The holy grail of data is to be able to help us predict what is to come, plan ahead and prevent future crisis and problems. Technologies like AI are helping us to do just this during the pandemic. Our ability to synthesise big data from genomics databases and population health statistics, with the support of AI, will allow us to carry out real-time molecular epidemiology - not just help us track past pandemics and manage current ones, but predict and prevent future ones. The main reason is that the current technology may not be mature enough. Despite the positive studies, there are also other studies that suggest caution needs to be taken before introducing AI systems into live production settings in health. In addition, for AI systems to be effective, they need access to data. However, a lot of data is proprietary and not shared publicly. We need to establish policies for a robust data governance framework – the “who, how, where and when” of data. We also need to establish the purpose of the data being collected and used – the “why” of data. As health information is the most valuable data that exists on the darkweb, steps must be taken to ensure that the data is protected. There are strong laws around ensuring privacy of health information, and policies and processes, as well as training, must be in place to maintain confidentiality and compliance with the law. We need more funding for further research into AI in health to support their safe and effective use in healthcare settings. Last but not least, we need to design our data systems to be patient-centred. In summary, the COVID-19 pandemic has accelerated the way data is used to help us understand our past, manage our present and predict our future, with the support of AI, and it is up to all of us, especially those who are in medical and digital health leadership roles, to ensure that we sustain these improvements in the post-pandemic world, so that we can prevent future pandemics.
Women's Representation on Regional People's Representative Council Padang City in Society Homogeneity
Authors: Magriasti Lince , Subono Nur Iman , Kosandi Meidi
Published: March 2022

This research aims to describe the process of nominating women for political parties and the electability of women in the regional representative council Padang City as seen from the 2014 and 2019 elections. Using the concept of Pitkin's descriptive political representation simplified by Phillips as a politics of presence, this paper describes women's electability in the Padang legislature with homogeneous community conditions with majority ethnicity are Minangkabau. The presence of women candidates in the Padang City legislature has benefited from the economic conditions owned both individually and by families. Political factors also show that there's still the influence of family politics in the candidacy of women. The level of incumbent electability was high from the 2014 to 2019 elections, but in quantity, there was a decrease in women's representation in the Padang City legislature. Meanwhile, if we look at the homogeneity of the people in Padang, conditions also follow it in the Padang legislature, which is also filled with representatives of women from Minangkabau ethnicity. However, this community homogeneity does not increase women in political institutions.
VRG Program Evaluation 2021. Accompanying Research
Authors:   AIT - Austria Institute of Technology, Hawlik Robert , Zieser Maximilian , Dinges Michael , Schiebel Edgar , Thijs Bart , Glänzel Wolfgang ,   KU Leuven
Published: March 2022

This report provides results from the accompanying research to the international review panel of the WWTF Vienna Research Groups for Young Investigators (VRG) program.
A Review for an Effective Approach towards Hydroelectric Power Generation Using In-Pipe Mesoscale Submersible Turbine
Authors: Khokhani Aayush , Kalavadiya Prince , Taviya Ravindra , Morker Zeel , Sibi Prof. Joseph
Published: March 2022

Abstract: Turbines are playing a massive role in our day-to-day lives in the back-end portion of lifestyles where they have been efficiently providing us energy through tidal, hydrological, and many such other mediums. A dominant explanation for the need for energy production has been introduced in the 1800s since the requirement for a high consumption of energy in various forms has started taking place. A very common method that has been observed in today’s innovative mannerism is the use of turbines in dams, undersea, elsewhere at locations where the flow of fluid induces better outputs. Vertical axis turbines, Francis turbines as well as Kaplan turbines have frequently opted for such purposes but after studying over 65 works done by adepts, professionals, and experts; the purposely implemented input that is required to fulfill the output doesn’t have to always be a necessity, it seemed to be the new designing restructured platform for users as well as providers. An overture to install micro versioned turbines of macro hydroelectric power plants within a residential or commercial structure at the main water-supply connections either at their junctions or directly near the overhead water tanks cannot just provide subtle but fortifying and tireless inputs since the flow of water will be anticipated naturally by the implicated outcomes through day-to-day chores performed. Hydrokinetic conversion systems may appear suitable in harvesting energy from such renewable resources, despite the fact that they are still in the early stages of development. Contrary to what has been assumed, there are numerous possibilities for the utilization of this energy for common areas/public zones such as signals, street lights, or any such productive amenities to bestow leading-edge facilities without any hitch regarding external contriving inputs. Keywords: Turbine, CFD Simulations, Archimedes screw, Water distribution logistics, Mini-Hydro-Power Plant, In-Pipe electricity generation, Inline hydroelectric generation.
EDUKASI PERILAKU HIDUP BERSIH DAN SEHAT DALAM UPAYA PENERAPAN COMMUNITY ORIENTED MEDICAL EDUCATION DI DESA PUHU, GIANYAR
Authors: Cahyawati (Scopus ID: 57203956416) Putu Nita , Wiguna I Made Adi Putra
Published: March 2022

Perilaku hidup bersih dan sehat (PHBS) merupakan salah satu upaya untuk mempertahankan kesehatan diri dan keluarga. Tujuan kegiatan pendampingan ini adalah untuk memberikan edukasi dan informasi kepada keluarga angkat mengenai perilaku hidup bersih dan sehat di lingkungan keluarga serta pentingnya menerapkan protokol kesehatan di masa pandemi Covid-19 ini. Kegiatan dilaksanakan secara langsung melalui kunjungan lapangan dan secara online dengan melibatkan 6 anggota keluarga angkat. Indikator keberhasilan program dinilai berdasarkan dua parameter yaitu: pelaksanakan program edukasi secara langsung dan peningkatan hasil posttest dibandingkan dengan pretest. Penilaian pelaksanaan program dikelompokkan menjadi 3 kategori yaitu: “Kurang” bila tidak ada indikator keberhasilan yang tercapai; “Cukup” bila satu indikator tercapai; dan “Baik” bila dua indikator tercapai. Hasil kegiatan ini menemukan bahwa terdapat peningkatan nilai postest dibandingkan nilai pretest. Kegiatan juga telah dilakukan secara langsung dan memperoleh respon positif dari keluarga angkat. Berdasarkan hasil ini, dapat disimpulkan bahwa program memenuhi indikator yang diharapkan dan termasuk dalam kategori “Baik” karena sudah dilaksanakan secara langsung dan terdapat peningkatan hasil posttest. Walaupun demikian, perilaku hidup bersih dan sehat memerlukan kesadaran diri dari setiap anggota keluarga terutama orang tua sebagai role model bagi anak-anaknya. Perilaku ini juga perlu dilakukan secara konsisten agar mampu mendapatkan hasil yang positif khususnya bagi kesehatan individu dan keluarga.
Belligerent GE-filters in GE-Algebras
Authors: Bandaru Ravikumar , Borumand Saeid Arsham , Jun Young Bae
Published: March 2022

The notion of a belligerent GE-filter in a GE-algebra is introduced, and the relationships between a GE-filter and a belligerent GE-filter will be given. Conditions for a GE-filter to be a belligerent GE-filter are provided. The product and the union of GE-algebras are discussed and its properties are investigated.
ASPECTOS ENVOLVIDOS NA GRAVIDEZ NA ADOLESCÊNCIA: UMA REVISÃO INTEGRATIVA
Authors: Cordeiro Ingrid Helena Danick , Ribeiro Giovanna Thomaz , Jardim Jessica Lorrany Da Rocha , Aguiar Rayanne Fernandes Rodrigues , Silva Júlia Sales da , Albuquerque Roberto Nascimento de
Published: March 2022

A gravidez precoce é considerada um obstáculo na vida da adolescente, afetando a vida da jovem em diferentes aspectos. Nesse contexto, a presente pesquisa tem como objetivo verificar os aspectos físicos, psicológicos e sociais envolvidos na gravidez na adolescência. Trata-se de uma revisão integrativa de literatura, realizada nos meses de março e abril de 2021 nas bases de dados da Scientific Eletronic Library Online (SciELO) e Biblioteca Virtual em Saúde (BVS). Incluíram-se artigos publicados nos últimos 10 anos, em português, disponíveis na íntegra e que contemplassem o tema proposto. Excluíram-se monografias, dissertações, teses e artigos de revisão. Encontraram-se 550 artigos, dos quais 21 deles foram utilizados para compor esta revisão integrativa. Optou-se por dividir os resultados em duas categorias: Alterações físicas ocorridas na gravidez e; Fatores socioculturais e emocionais envolvidos na gravidez na adolescência. Como o adolescente ainda não tem um organismo completamente desenvolvido, uma gestão nesta fase pode acarretar em diversos riscos físicos, tanto para a adolescente quanto para o bebê. Além disso, a falta de informação, baixa adesão às consultas pré-natais, bem como fatores socioculturais e emocionais afetam diretamente a adolescente gestante, podendo levar a sérios transtornos mentais, tais como depressão, depressão pós-parto, psicoses puerperais, abortos espontâneos e provocados. Portanto, políticas públicas eficientes e eficazes são necessárias para um atendimento integral à essa jovem grávida.
RELAÇÃO ENTRE CONSUMO ALIMENTAR E ESTADO NUTRICIONAL DE ESCOLARES: UM ESTUDO DE REVISÃO
Authors: Girotto Larissa , Fassina Patrícia
Published: March 2022

O objetivo do atual do estudo foi determinar a relação entre consumo alimentar e estado nutricional de escolares. O estudo consistiu em uma revisão bibliográfica sistemática através de estudos científicos consultados nas bases de dados PubMed, Lilacs, SciELO e Google Acadêmico por meio dos seguintes descritores e de suas combinações na língua portuguesa: “consumo alimentar”, “estado nutricional”, “relação consumo alimentar e estado nutricional de crianças”, no período de 2015 a 2020. Foram encontrados 18 artigos e, através dos critérios de inclusão e exclusão, apenas 10 foram selecionados para comporem o quadro de resultados por estarem diretamente relacionados ao objetivo deste estudo. Dos 10 artigos selecionados, sete apresentaram associação entre o consumo alimentar e estado nutricional, nos quais a maioria das crianças apresentaram sobrepeso e obesidade relacionados com a prática de uma alimentação mais calórica, com alto consumo de alimentos industrializados e baixo consumo de alimentos in natura. Os outros três estudos não encontraram relação significativa entre essas duas variáveis, pois tanto crianças eutróficas quanto crianças com sobrepeso e obesidade consumiam basicamente os mesmos alimentos. Concluiu-se que, a maior parte dos estudos demonstrou que as crianças em sobrepeso/obesidade possuíam uma alimentação mais energética, com elevado consumo de alimentos industrializados e baixo consumo de frutas, legumes e verduras.
Avanceret søgning i fælleskatalogen
Authors: Andresen Leif , Greve Eli
Published: March 2022

I bibliotek.dk er avanceret søgning ikke længere default. Det bør seriøst testes, om det skal genindføres. Avanceret søgning bør analyseres for at sikre en optimering af brugernes søgninger.
Redaktørskifte sætter tanker i gang
Authors: DFFU Bestyrelsen
Published: March 2022

Input efterlyses: Skal DFFU som forening i langt højere grad blande os i samfundsbatten og den aktuelle politiske dagsorden – og bliver REVYs mange gode artikler læst?
Exertional heat stroke-related rhabdomyolysis recurring twice in a 12-year-old boy athlete
Authors: Kwon Soo Jin , Cha Jong Ho , Kim Yong Joo , Yang Seung , Moon Jin-Hwa , Na Jae Yoon
Published: March 2022

Exertional heat stroke (EHS) is a life-threatening entity characterized by elevated core temperature with potential for multiorgan dysfunction. EHS-related rhabdomyolysis usually occurs in the early phase. We report a boy athlete with EHS-related rhabdomyolysis, which recurred 15 and 79 days after the initial event. This case indicates that EHS can cause recurrences of rhabdomyolysis along with persistent symptoms, which could hamper the return to daily activity. Children with EHS, particularly athletes, may be at risk for recurrent rhabdomyolysis.
Learning takes time: Biotic resistance by native herbivores increases through the invasion process.
Authors: Santamaría Jorge , Golo Raül , Verdura Jana , Tomas Fiona , Ballesteros Enric , Alcoverro Teresa , Arthur Rohan , Cebrian Emma
Published: March 2022

As invasive species spread, the ability of local communities to resist
invasion depends on the strength of biotic interactions. Evolutionarily
unused to the invader, native predators or herbivores may be initially
wary of consuming newcomers, allowing them to proliferate. However,
these relationships may be highly dynamic, and novel consumer-resource
interactions could form as familiarity grows. Here, we explore the
development of effective biotic resistance towards a highly invasive
alga using multiple space-for-time approaches. We show that the
principal native Mediterranean herbivore learns to consume the invader
within less than a decade. At recently invaded sites, the herbivore
actively avoided the alga, shifting to distinct preference and high
consumptions at older sites. This rapid strengthening of the interaction
contributed to the eventual collapse of the alga after an initial
dominance. Therefore, our results stress the importance of conserving
key native populations to allow communities to develop effective
resistance mechanisms against invaders.
Epidemiology and clinic of microbial-inflammatory nephropathy in children living in an ecologically unfavorable region
Authors: Sitnikova E. P. , Pukhova T. G. , Spivak E. M.
Published: March 2022

The aim is to establish the epidemiology and features of the clinic of microbial inflammatory nephropathy in children living in an ecologically unfavorable area.Research methods. The prevalence of microbial-inflammatory nephropathies and their incidence in the urban children's population, as well as in areas with favorable and unfavorable environmental situation were analyzed. A clinical and laboratory examination of patients was carried out with an assessment of the features of the manifestations of the disease in children living in an area with environmental pollution.The results of the study. Over the past two decades, there has been a decrease in the incidence of microbial inflammatory nephropathies and their general prevalence in the urban children's population. However, in an urban area with an unfavorable environmental situation, a significant increase in these epidemiological indicators has been recorded over a ten-year period. The peculiarities of microbial-inflammatory nephropathies in children living in an area with significant air and soil pollution are their occurrence against the background of congenital anomalies or malformations of the kidneys and urinary tract, frequent relapses, the presence of complications. They are characterized by a frequent combination of kidney and bladder lesions, higher activity of the inflammatory process with impaired renal function, slow reverse dynamics of symptoms during treatment.Conclusion. Microbial-inflammatory nephropathies in children living in ecologically unfavorable areas of the city have features of epidemiology and clinical manifestations, which must be taken into account when carrying out medical support for this category of patients.