bluuebunny/crossref_metadata_2025 huggingface dataset:
Examining the Effects of Land Use on Carbon Emissions: Evidence from Pearl River Delta
Authors: Zhao Yabo , Ma Shifa , Fan Jianhong , Cai Yunnan
Published: March 2021

Land-use change accounts for a large proportion of the carbon emissions produced each year, especially in highly developed urban agglomerations. In this study, we combined remote sensing data and socioeconomic data to estimate land-use-related carbon emissions, and applied the logarithmic mean Divisia index (LMDI) method to analyze its influencing factors, in the Pearl River Delta (PRD) of China in 1990–2015. The main conclusions are as follows: (1) The total amount of land-use-related carbon emissions increased from 684.84 × 104 t C in 1990 to 11,444.98 × 104 t C in 2015, resulting in a net increase of 10,760.14 × 104 t (16.71 times). (2) Land-use-related carbon emissions presented a “higher in the middle and lower on both sides” spatial distribution. Guangzhou had the highest levels of carbon emissions, and Zhaoqing had the lowest; Shenzhen experienced the greatest net increase, and Jiangmen experienced the least. (3) The land-use-related carbon emissions intensity increased from 4795.76 × 104 Yuan/t C to 12,143.05 × 104 Yuan/t C in 1990–2015, with the greatest increase seen in Huizhou and the lowest in Zhongshan. Differences were also found in the spatial distribution, with higher intensities located in the south, lower intensities in the east and west, and medium intensities in the central region. (4) Land-use change, energy structure, energy efficiency, economic development, and population all contributed to increases in land-use-related carbon emissions. Land-use change, economic development and population made positive contributions, while energy efficiency and energy structure made negative contributions. At last, we put forward several suggestions for promoting low-carbon development, including development of a low-carbon and circular economy, rationally planning land-use structure, promoting reasonable population growth, improving energy efficiency and the energy consumption structure, and advocating low-carbon lifestyles. Our findings are useful in the tasks related to assessing carbon emissions from the perspective of land-use change and analyzing the associated influencing factors, as well as providing a reference for realizing low-carbon and sustainable development in the PRD.
Asymptomatic Patients with Severe Aortic Stenosis and the Impact of Intervention
Authors: Çelik Mevlüt , Milojevic Milan , Durko Andras P. , Oei Frans B. S. , Mahtab Edris A. F. , Bogers Ad J. J. C.
Published: March 2021

Objectives the exact timing of aortic valve replacement (AVR) in asymptomatic patients with severe aortic stenosis (AS) remains a matter of debate. Therefore, we described the natural history of asymptomatic patients with severe AS, and the effect of AVR on long-term survival. Methods: Asymptomatic patients who were found to have severe AS between June 2006 and May 2009 were included. Severe aortic stenosis was defined as peak aortic jet velocity Vmax ≥ 4.0 m/s or aortic valve area (AVA) ≤ 1 cm2. Development of symptoms, the incidence of AVR, and all-cause mortality were assessed. Results: A total of 59 asymptomatic patients with severe AS were followed, with a mean follow-up of 8.9 ± 0.4 years. A total of 51 (86.4%) patients developed AS related symptoms, and subsequently 46 patients underwent AVR. The mean 1-year, 2-year, 5-year, and 10-year overall survival rates were higher in patients receiving AVR compared to those who did not undergo AVR during follow-up (100%, 93.5%, 89.1%, and 69.4%, versus 92.3%, 84.6%, 65.8%, and 28.2%, respectively; p < 0.001). Asymptomatic patients with severe AS receiving AVR during follow-up showed an incremental benefit in survival of up to 31.9 months compared to conservatively managed patients (p = 0.002). Conclusions: The majority of asymptomatic patients turn symptomatic during follow-up. AVR during follow-up is associated with better survival in asymptomatic severe AS patients.
The Spatial Changes of Transportation Infrastructure and Its Threshold Effects on Urban Land Use Efficiency: Evidence from China
Authors: Lu Xinhai , Wang Mengcheng , Tang Yifeng
Published: March 2021

The development of social production and the agglomeration of the urban population have brought tremendous pressure to transportation infrastructure. However, the impacts of transportation development on urban land use systems have not been well investigated. Under the pressure of limited land resources, the impact of transportation infrastructure on urban land use efficiency (ULUE) is receiving increasing attention from scholars and needs to be explored. By collecting panel data from 30 regions in China from 2003 to 2018, in this study we constructed a spatial Durbin model and a panel threshold regression model to explore the spatial spillover effects and threshold effects of transportation infrastructure on ULUE. The most obvious findings emerging from this study are that (1) ULUE is not randomly distributed over different regions in China, but has an obvious positive spatial correlation; (2) transportation infrastructure has significant positive direct and spatial spillover effects on ULUE and the direct effects of transportation infrastructure (0.823) are significantly stronger than the spatial spillover effects (0.263); (3) the impact of transportation infrastructure on ULUE has a significant double threshold effect, and the threshold values are 4.520 and 6.429 respectively, and with the improvement of transportation infrastructure, its marginal effects on ULUE show a downward trend. This paper provides theoretical support for policymakers to achieve cross-regional cooperation on land use and transportation infrastructure construction and inspirations for sustainable development.
Farmland Use Transition in a Typical Farming Area: The Case of Sihong County in the Huang-Huai-Hai Plain of China
Authors: Lyu Ligang , Gao Zhoubing , Long Hualou , Wang Xiaorui , Fan Yeting
Published: March 2021

An in-depth exploration of the dynamics and existing problems in farmland morphology is crucial to formulate targeted protection policies. In this study, we constructed a morphological evaluation index system to identify the characteristics of farmland use transition in Sihong County of the Huang-Huai-Hai Plain, China. The dominant morphology in terms of area and landscape pattern and the recessive morphology focusing on function were considered in this work. Based on this information, the driving factors of farmland use transition were quantitatively analyzed via the mixed regression model. The following major findings were determined: (1) The area showed a U-shaped change trend during 2009–2018. The patch density (PD) showed an upward trend, and the mean patch size (MPS) showed a downward trend, indicating that the degree of farmland fragmentation increased. The implementation of land consolidation projects increased the area and aggregation of farmland, while urbanization and road construction occupied and divided the farmland, leading to a reduction in area and increase in the degree of fragmentation. (2) The crop production, living security, and eco-environmental function of farmland showed a trend of first decreasing and then increasing. Urbanization increased the demand for agricultural products and the degree of large-scale agricultural production and had a positive impact on the crop production and eco-environmental function of farmland. Our research highlights that increasing farmland fragmentation should be addressed in the farming area. Therefore, the government should formulate efficient policies to curb farmland occupation for urban and traffic utilization.
Synergistic and Competitive Effects between Zinc Dialkyldithiophosphates and Modern Generation of Additives in Engine Oil
Authors: Huynh Khai K. , Tieu Kiet A. , Pham Sang T.
Published: March 2021

The increasing demand for low-viscosity engine oil has underscored the role of zinc dialkyldithiophosphates (ZDDP) as a conventional anti-wear and antioxidant additive. It is essential to investigate the influence of modern additives such as cyclopropanecarboxylic acid (CPCa) and Ni nanoparticles on the tribological performance of ZDDP for practical commercial oil application. According to the experimental results, Ni nanoparticles formed a protective film that exhibited a synergistic effect with ZDDP. A significantly higher concentration of sulphur in the tribofilm was detected compared to ZDDP by itself, which was responsible for a 27.6% lower wear loss. Meanwhile, a competitive effect between CPCa and ZDDP resulted in a dramatic increase in friction and unstable anti-wear performance. This was demonstrated by a localized formation of the ZDDP tribofilm on the wear surfaces after the friction test. These results have highlighted the synergistic and competitive effects of emerging additives (CPCa and Ni nanoparticles) in the ZDDP tribofilm formation between the sliding steel contacts. This further suggests a new approach to increase the efficiency of ZDDP’s tribological performance at cold start-up processes.
Special Issue: Advances in Transmission Electron Microscopy for the Study of Soft and Hard Matter
Authors: Carlino Elvio
Published: March 2021

Transmission Electron Microscopy (TEM) owes its success to the capability to investigate fundamental aspects of nature, answering the human need of knowledge necessary to understand unknown mechanisms and to find new solutions in a variety of fields like physics, biology, medicine, engineering, or chemistry [...]
Mechanical Behavior and Morphological Study of Polytetrafluoroethylene (PTFE) Composites under Static and Cyclic Loading Condition
Authors: Mazur Karolina , Gądek-Moszczak Aneta , Liber-Kneć Aneta , Kuciel Stanisław
Published: March 2021

The key goal of this study was to characterize polytetrafluoroethylene (PTFE) based composites with the addition of bronze particles and mineral fibers/particles. The addition of individual fillers was as follows: bronze—30–60 wt.%, glass fibers—15–25 wt.%, coke flakes—25 wt.% and graphite particles—5 wt.%. Both static and dynamic tests were performed and the obtained results were compared with the microscopic structure of the obtained fractures. The research showed that the addition of 60 wt.% bronze and other mineral fillers improved the values obtained in the static compression test and in the case of composites with 25 wt.% glass fibers the increase was about 60%. Fatigue tests have been performed for the compression-compression load up to 100,000 cycles. All tested composites show a significant increase in the modulus as compared to the values obtained in the static compression test. The highest increase in the modulus in the dynamic test was obtained for composites with 25 wt.% of glass fibers (increase by 85%) and 25 wt.% of coke flakes (increase by 77%), while the lowest result was obtained for the lowest content of bronze particles (decrease by 8%). Dynamic tests have shown that composites with “semi-spherical” particles are characterized by the longest service life and a slower fatigue crack propagation rate than in the case of the long glass fibers. In addition, studies have shown that particles with smaller sizes and more spherical shape have a higher ability to dissipate mechanical energy, which allows their use in friction nodes. On the other hand, composites with glass fiber and graphite particles can be successfully used in applications requiring high stiffness with low amplitude vibrations.
A Pilot Study of Safer Radiation Dosage to the Heart and Its Subregions
Authors: Steponavičienė Rita , Jonušas Justinas , Griškevičius Romualdas , Venius Jonas , Cicėnas Saulius
Published: March 2021

Background and Objectives: The real impact of ionizing radiation on the heart and poorer overall survival for patients with non small cell lung cancer (NSCLC) remains unclear. This study aims to determine the safe dose constraints to the heart’s subregions that could prevent patients’ early non-cancerous death and improve their quality of life. Methods and Materials: A retrospective cohort study was performed containing 51 consecutive patients diagnosed with stage III NSCLC and treated using 3D, Intensity-modulated radiation therapy (IMRT), and Volumetric modulated arc therapy (VMAT) radiotherapy. For a dosimetric analysis, these structures were chosen: heart, heart base (HB), and region of great blood vessels (GBV). Dose–volume histograms (DVH) were recorded for all mentioned structures. Maximum and mean doses to the heart, HB, the muscle mass of the HB, and GBV were obtained. V10–V60 (%) parameters were calculated from the DVH. After performed statistical analysis, logistic regression models were created, and critical doses calculated. Results: The critical dose for developing a fatal endpoint for HB was 30.5 Gy, while for GBV, it was 46.3 Gy. Increasing the average dose to the HB or GBV by 1 Gy from the critical dose further increases the possibility of early death by 22.0% and 15.8%, respectively. Conclusions: We suggest that the non-canonical sub-regions of the heart (HB and GBV) should be considered during the planning stage. Additional constraints of the heart subregions should be chosen accordingly, and we propose that the mean doses to these regions be 30.5 Gy and 46.3 Gy, respectively, or less. Extrapolated DVH curves for both regions may be used during the planning stage with care.
Absence of 4-Formylaminooxyvinylglycine Production by Pseudomonas fluorescens WH6 Results in Resource Reallocation from Secondary Metabolite Production to Rhizocompetence
Authors: Manning Viola A. , Trippe Kristin M.
Published: March 2021

Pseudomonas fluorescens WH6 produces the non-proteinogenic amino acid 4-formylaminooxyvinylglycine (FVG), a secondary metabolite with antibacterial and pre-emergent herbicidal activities. The gvg operon necessary for FVG production encodes eight required genes: one regulatory (gvgR), two of unknown functional potential (gvgA and C), three with putative biosynthetic function (gvgF, H, and I), and two small ORFs (gvgB and G). To gain insight into the role of GvgA and C in FVG production, we compared the transcriptome of knockout (KO) mutants of gvgR, A, and C to wild type (WT) to test two hypotheses: (1) GvgA and GvgC play a regulatory role in FVG production and (2) non-gvg cluster genes are regulated by GvgA and GvgC. Our analyses show that, collectively, 687 genes, including the gvg operon, are differentially expressed in all KO strains versus WT, representing >10% of the genome. Fifty-one percent of these genes were similarly regulated in all KO strains with GvgC having the greatest number of uniquely regulated genes. Additional transcriptome data suggest cluster regulation through feedback of a cluster product. We also discovered that FVG biosynthesis is regulated by L-glu, L-asp, L-gln, and L-asn and that resources are reallocated in KO strains to increase phenotypes involved in rhizocompetence including motility, biofilm formation, and denitrification. Altogether, differential transcriptome analyses of mutants suggest that regulation of the cluster is multifaceted and the absence of FVG production or its downregulation can dramatically shift the lifestyle of WH6.
Multi Locus Sequence Typing and spa Typing of Staphylococcus aureus Isolated from the Milk of Cows with Subclinical Mastitis in Croatia
Authors: Cvetnić Luka , Samardžija Marko , Duvnjak Sanja , Habrun Boris , Cvetnić Marija , Jaki Tkalec Vesna , Đuričić Dražen , Benić Miroslav
Published: March 2021

Background: The bacterial species S. aureus is the most common causative agent of mastitis in cows in most countries with a dairy industry. The prevalence of infection caused by S. aureus ranges from 2% to more than 50%, and it causes 10–12% of all cases of clinical mastitis. Aim: The objective was to analyze 237 strains of S. aureus isolated from the milk of cows with subclinical mastitis regarding the spa, mecA, mecC and pvl genes and to perform spa and multi-locus sequence typing (MLST). Methods: Sequencing amplified gene sequences was conducted at Macrogen Europe. Ridom StaphType and BioNumerics software was used to analyze obtained sequences of spa and seven housekeeping genes. Results: The spa fragment was present in 204 (86.1%) of strains, while mecA and mecC gene were detected in 10 strains, and the pvl gene was not detected. Spa typing successfully analyzed 153 tested isolates (64.3%), confirming 53 spa types, four of which were new types. The most frequent spa type was t2678 (14%). MLST typed 198 (83.5%) tested strains and defined 32 different allele profiles, of which three were new. The most frequent allele profile was ST133 (20.7%). Six groups (G) and 15 singletons were defined. Conclusion: Taking the number of confirmed spa types and sequence types (STs) into account, it can be concluded that the strains of S. aureus isolated from the milk of cows with subclinical mastitis form a heterogenous group. To check the possible zoonotic potential of isolates it would be necessary to test the persons and other livestock on the farms.
Thrombin-Derived Peptides Potentiate the Activity of Gram-Positive-Specific Antibiotics against Gram-Negative Bacteria
Authors: Wesseling Charlotte M. J. , Wood Thomas M. , Slingerland Cornelis J. , Bertheussen Kristine , Lok Samantha , Martin Nathaniel I.
Published: March 2021

The continued rise of antibiotic resistance threatens to undermine the utility of the world’s current antibiotic arsenal. This problem is particularly troubling when it comes to Gram-negative pathogens for which there are inherently fewer antibiotics available. To address this challenge, recent attention has been focused on finding compounds capable of disrupting the Gram-negative outer membrane as a means of potentiating otherwise Gram-positive-specific antibiotics. In this regard, agents capable of binding to the lipopolysaccharide (LPS) present in the Gram-negative outer membrane are of particular interest as synergists. Recently, thrombin-derived C-terminal peptides (TCPs) were reported to exhibit unique LPS-binding properties. We here describe investigations establishing the capacity of TCPs to act as synergists with the antibiotics erythromycin, rifampicin, novobiocin, and vancomycin against multiple Gram-negative strains including polymyxin-resistant clinical isolates. We further assessed the structural features most important for the observed synergy and characterized the outer membrane permeabilizing activity of the most potent synergists. Our investigations highlight the potential for such peptides in expanding the therapeutic range of antibiotics typically only used to treat Gram-positive infections.
Ethanol to Acetaldehyde Conversion under Thermal and Microwave Heating of ZnO-CuO-SiO2 Modified with WC Nanoparticles
Authors: Kustov Alexander L. , Tarasov Andrey L. , Tkachenko Olga P. , Mishin Igor V. , Kapustin Gennady I. , Kustov Leonid M.
Published: March 2021

The nonoxidative conversion of ethanol to acetaldehyde under thermal and microwave heating was studied on mixed oxide ZnO-CuO-SiO2 catalysts modified with additives of tungsten carbide nanoparticles. The results revealed that the WC-modified catalyst exhibited superior activity and selectivity under microwave heating conditions. It is assumed that when microwave heating is used, hot zones can appear at the contact points of WC nanoparticles and active centers of the mixed oxide ZnO-CuO-SiO2 catalyst, which intensively absorb microwave energy, allowing the more efficient formation of acetaldehyde at moderate temperatures. Thermodynamic calculations of equilibrium concentrations of reagents and products allowed us to identify the optimal conditions for effective acetaldehyde production. The initial catalyst and the catalyst prepared by the coprecipitation of the oxides with the addition of WC were characterized by physicochemical methods (TPR-H2, XRD, DRIFTS of adsorbed CO). The active centers of the oxide catalyst can be Cu+ cations.
Generation of Unusual Aromatic Polyketides by Incorporation of Phenylamine Analogues into a C-Ring-Cleaved Angucyclinone
Authors: Xiao Hua , Wang Guiyang , Wang Zhengdong , Kuang Yi , Song Juan , Jin Jing , Ye Min , Yang Donghui , Ma Ming
Published: March 2021

Angucyclinones are aromatic polyketides that possess impressive structural diversity and significant biological activities. The structural diversity of these natural products is attributed to various enzymatic or nonenzymatic modifications on their tetracyclic benz(a)anthracene skeleton. Previously, we discovered an unusual phenylamine-incorporated angucyclinone (1) from a marine Streptomyces sp. PKU-MA00218, and identified that it was produced from the nonenzymatic conversion of a C-ring-cleaved angucyclinone (2) with phenylamine. In this study, we tested the nonenzymatic conversion of 2 with more phenylamine analogues, to expand the utility of this feasible conversion in unusual angucyclinones generation. The (3-ethynyl)phenylamine and disubstituted analogues including (3,4-dimethyl)phenylamine, (3,4-methylenedioxy)phenylamine, and (4-bromo-3-methyl)phenylamine were used in the conversion of 2, which was isolated from the fermentation of Streptomyces sp. PKU-MA00218. All four phenylamine analogues were incorporated into 2 efficiently under mild conditions, generating new compounds 3–6. The activation of 3–6 on nuclear factor erythroid 2-related factor 2 (Nrf2) transcription were tested, which showed that 4 possessing a dimethyl-substitution gave most potent activity. These results evidenced that disubstitutions on phenylamine can be roughly tolerated in the nonenzymatic reactions with 2, suggesting extended applications of more disubstituted phenylamines incorporation to generate new bioactive angucyclinones in the future.
Using the Method of “Optical Biopsy” of Prostatic Tissue to Diagnose Prostate Cancer
Authors: Artemyev Dmitry N. , Kukushkin Vladimir I. , Avraamova Sofia T. , Aleksandrov Nikolay S. , Kirillov Yuri A.
Published: March 2021

The possibilities of using optical spectroscopy methods in the differential diagnosis of prostate cancer were investigated. Analytical discrimination models of Raman spectra of prostate tissue were constructed by using the projections onto latent structures data analysis(PLS-DA) method for different wavelengths of exciting radiation—532 and 785 nm. These models allowed us to divide the Raman spectra of prostate cancer and the spectra of hyperplasia sites for validation datasets with the accuracy of 70–80%, depending on the specificity value. Meanwhile, for the calibration datasets, the accuracy values reached 100% for the excitation of a laser with a wavelength of 785 nm. Due to the registration of Raman “fingerprints”, the main features of cellular metabolism occurring in the tissue of a malignant prostate tumor were confirmed, namely the absence of aerobic glycolysis, over-expression of markers (FASN, SREBP1, stearoyl-CoA desaturase, etc.), and a strong increase in the concentration of cholesterol and its esters, as well as fatty acids and glutamic acid. The presence of an ensemble of Raman peaks with increased intensity, inherent in fatty acid, beta-glucose, glutamic acid, and cholesterol, is a fundamental factor for the identification of prostate cancer.
Preparation of Microemulsion from an Alkyl Polyglycoside Surfactant and Tea Tree Oil
Authors: Vo Thuy-Vi , Chou Ya-Yen , Chen Bing-Hung
Published: March 2021

Preparation and characterization of microemulsions consisting of a plant-derived alkyl polyglycoside (APG) surfactant and the essential oil of Melaleuca alternifolia (tea tree) was studied. This nonionic APG surfactant used was Triton CG-110 with a CMC at 1748 ppm at 25 °C. Tea tree oil (TTO) was extracted from tea tree leaves by Triton CG-110-assisted hydrodistillation method. The preparation of the microemulsion was aided by the construction of pseudo-ternary phase diagrams, which were investigated at the different weight ratios of surfactant mixtures (Smix = Triton CG-110/PPG) as 0.6:1, 1.8:1, 1:0 with hydrodistilled and commercial TTO by water titration method at room temperature. Particularly, structure of microemulsion was identified by electrical conductivity and viscosity. Moreover, shelf stability of some microemulsion made of 1% TTO with various concentration of Triton CG-110/PPG (1.8:1 w/w) were monitored for over a two-month period with dynamic light scattering. These results showed that microemulsion made of 1% TTO, 9% Triton CG-110/PPG (1.8:1 w/w) was insensitive with time and temperature of storage.
Poly(Methyl Methacrylate) Coatings Containing Flame Retardant Additives from Suspensions in Water-2-Propanol
Authors: Li Xuelin , Wang Zhengzheng , Sakib Sadman , Mathews Ritch , Zhitomirsky Igor
Published: March 2021

A dip-coating technique is designed for deposition of poly(methyl methacrylate) (PMMA) from water/2-propanol mixture, avoiding the use of traditional toxic solvents. Solutions of PMMA macromolecules with high molecular weight (MW) are obtained for a water/2-propanol ratio of 0.15–0.33 and the solubilization mechanism is discussed. The ability to use concentrated PMMA solutions and high MW of the polymer are the key factors for the successful dip coating deposition. The coating mass for 10 g L−1 polymer solutions shows a maximum at a water/2-propanol ratio of 0.25. The deposition yield increases with the polymer concentration increase and with an increasing number of the deposited layers. PMMA deposits protect stainless steel from aqueous corrosion. The coating technique allows for the fabrication of composite coatings, containing flame-retardant materials (FRMs), such as commercial halloysite, huntite, hydrotalcite, and synthesized Al(OH)3, in the PMMA matrix. The FRM content in the coatings is modified by variation of the FRM content in colloidal suspensions. A fundamentally new method is developed, which is based on the salting out aided dispersive extraction of Al(OH)3 from the aqueous synthesis medium to 2-propanol. It is based on the use of hexadecylphosphonic acid molecules as extractors. The method offers advantages of reduced agglomeration.
The Mechanistic Roles of ncRNAs in Promoting and Supporting Chemoresistance of Colorectal Cancer
Authors: Micallef Isaac , Baron Byron
Published: March 2021

Colorectal Cancer (CRC) is one of the most common gastrointestinal malignancies which has quite a high mortality rate. Despite the advances made in CRC treatment, effective therapy is still quite challenging, particularly due to resistance arising throughout the treatment regimen. Several studies have been carried out to identify CRC chemoresistance mechanisms, with research showing different signalling pathways, certain ATP binding cassette (ABC) transporters and epithelial mesenchymal transition (EMT), among others to be responsible for the failure of CRC chemotherapies. In the last decade, it has become increasingly evident that certain non-coding RNA (ncRNA) families are involved in chemoresistance. Research investigations have demonstrated that dysregulation of microRNAs (miRNAs), long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) contribute towards promoting resistance in CRC via different mechanisms. Considering the currently available data on this phenomenon, a better understanding of how these ncRNAs participate in chemoresistance can lead to suitable solutions to overcome this problem in CRC. This review will first focus on discussing the different mechanisms of CRC resistance identified so far. The focus will then shift onto the roles of miRNAs, lncRNAs and circRNAs in promoting 5-fluorouracil (5-FU), oxaliplatin (OXA), cisplatin and doxorubicin (DOX) resistance in CRC, specifically using ncRNAs which have been recently identified and validated under in vivo or in vitro conditions.
A Message from the Editor-in-Chief for Pharmacy—A Journal of Pharmacy Education and Practice
Authors: Schommer Jon C.
Published: March 2021

Dear Reader of Pharmacy, [...]
Avalanche Photodiodes with Dual Multiplication Layers for High-Speed and Wide Dynamic Range Performances
Authors: Naseem  , Ahmad Zohauddin , Liao Yan-Min , Chao Rui-Lin , Wang Po-Shun , Lee Yi-Shan , Yang Sean , Wang Sheng-Yun , Chang Hsiang-Szu , Chen Hung-Shiang , Huang Jack Jia-Sheng , Chou Emin , Jan Yu-Heng , Shi Jin-Wei
Published: March 2021

In this work, we demonstrate In0.52Al0.48As top/backside-illuminated avalanche photodiodes (APD) with dual multiplication layers for high-speed and wide dynamic range performances. Our fabricated top-illuminated APDs, with a partially depleted p-type In0.53Ga0.47As absorber layer and thin In0.52Al0.48As dual multiplication (M-) layer (60 and 88 nm), exhibit a wide optical-to-electrical bandwidth (16 GHz) with high responsivity (2.5 A/W) under strong light illumination (around 1 mW). The measured bias dependent 3-dB O-E bandwidth was pinned at 16 GHz without any serious degradation near the saturation current output. To further increase the speed, we downscaled the active diameter and adopted a back-side illuminated structure with flip-chip bonding for batter optical alignment tolerance. A significant improvement in maximum bandwidth was demonstrated (25 versus 18 GHz). On the other hand, we adopted a thick dual M-layer (200 and 300 nm) and 2 μm absorber layer in the APD design to circumvent the problem of serious bandwidth degradation under high gain (>100) and high-power operation which significantly enhanced the dynamic range. Due to dual M-layer, the carriers could be energized in the first M-layer then propagate to the second M-layer to trigger the avalanche process. In both cases, despite variation in thickness of the absorber and M-layer, the cascade avalanche process leads to values close to the ultra-high gain bandwidth product (GBP) of around 460 GHz with a responsivity of 0.4 and 1 A/W at unit gain for the thin and thick M-layer devices, respectively. We successfully achieved a good sensitivity of around −20.6 dBm optical modulation amplitude (OMA) at a data rate of 25.78 Gb/s, by packaging the fabricated APDs (thin dual M-layer (60 and 88 nm) version) with a 25 Gb/s trans-impedance amplifier in a 100 Gb/s ROSA package. The results show that, the incorporation of a dual multiplication (M) layer structure in the APD opens a new window to obtaining the higher GBP in order to meet the requirements for high-speed transmission without the need of further downscaling the multiplication layer.
Genome-Wide Analysis of Tubulin Gene Family in Cassava and Expression of Family Member FtsZ2-1 during Various Stress
Authors: Li Shuangbao , Cao Peng , Wang Congcong , Guo Jianchun , Zang Yuwei , Wu Kunlin , Ran Fangfang , Liu Liangwang , Wang Dayong , Min Yi
Published: March 2021

Filamentous temperature-sensitive protein Z (Tubulin/FtsZ) family is a group of conserved GTP-binding (guanine nucleotide-binding) proteins, which are closely related to plant tissue development and organ formation as the major component of the cytoskeleton. According to the published genome sequence information of cassava (Manihot esculenta Crantz), 23 tubulin genes (MeTubulins) were identified, which were divided into four main groups based on their type and phylogenetic characteristics. The same grouping generally has the same or similar motif composition and exon–intron structure. Collinear analysis showed that fragment repetition event is the main factor in amplification of cassava tubulin superfamily gene. The expression profiles of MeTubulin genes in various tissue were analyzed, and it was found that MeTubulins were mainly expressed in leaf, petiole, and stem, while FtsZ2-1 was highly expressed in storage root. The qRT-PCR results of the FtsZ2-1 gene under hormone and abiotic stresses showed that indole-3-acetic acid (IAA) and gibberellin A3 (GA3) stresses could significantly increase the expression of the FtsZ2-1 gene, thereby revealing the potential role of FtsZ2-1 in IAA and GA3 stress-induced responses.
Recent Advances in the Synthesis of Nanocellulose Functionalized–Hybrid Membranes and Application in Water Quality Improvement
Authors: Mbakop Sandrine , Nthunya Lebea N. , Onyango Maurice S.
Published: March 2021

The increasing discharge of voluminous non or partially treated wastewaters characterized by complex contaminants poses significant ecological and health risks. Particularly, this practice impacts negatively on socio-economic, technological, industrial, and agricultural development. Therefore, effective control of water pollution is imperative. Over the past decade, membrane filtration has been established as an effective and commercially attractive technology for the separation and purification of water. The performance of membrane-based technologies relies on the intrinsic properties of the membrane barrier itself. As a result, the development of innovative techniques for the preparation of highly efficient membranes has received remarkable attention. Moreover, growing concerns related to cost-effective and greener technologies have induced the need for eco-friendly, renewable, biodegradable, and sustainable source materials for membrane fabrication. Recently, advances in nanotechnology have led to the development of new high-tech nanomaterials from natural polymers (e.g., cellulose) for the preparation of environmentally benign nanocomposite membranes. The synthesis of nanocomposite membranes using nanocelluloses (NCs) has become a prominent research field. This is attributed to the exceptional characteristics of these nanomaterials (NMs) namely; excellent and tuneable surface chemistry, high mechanical strength, low-cost, biodegradability, biocompatibility, and renewability. For this purpose, the current paper opens with a comprehensive yet concise description of the various types of NCs and their most broadly utilized production techniques. This is closely followed by a critical review of how NC substrates and their surface-modified versions affect the performance of the fabricated NC-based membranes in various filtration processes. Finally, the most recent processing technologies for the preparation of functionalized NCs-based composite membranes are discussed in detail and their hybrid characteristics relevant to membrane filtration processes are highlighted.
Multi-UAV Area Coverage Based on Relative Localization: Algorithms and Optimal UAV Placement
Authors: Zhang Ziyong , Xu Xiaoling , Cui Jinqiang , Meng Wei
Published: March 2021

This paper is concerned with relative localization-based optimal area coverage placement using multiple unmanned aerial vehicles (UAVs). It is assumed that only one of the UAVs has its global position information before performing the area coverage task and that ranging measurements can be obtained among the UAVs by using ultra-wide band (UWB) sensors. In this case, multi-UAV relative localization and cooperative coverage control have to be run simultaneously, which is a quite challenging task. In this paper, we propose a single-landmark-based relative localization algorithm, combined with a distributed coverage control law. At the same time, the optimal multi-UAV placement problem was formulated as a quadratic programming problem by compromising between optimal relative localization and optimal coverage control and was solved by using Sequential Quadratic Programming (SQP) algorithms. Simulation results show that our proposed method can guarantee that a team of UAVs can efficiently localize themselves in a cooperative manner and, at the same time, complete the area coverage task.
Simulation Study on Performance Optimization of Magnetic Nanoparticles DC Thermometry Model
Authors: Zhang Yapeng , Ma Shuangbao , Liu Wenzhong
Published: March 2021

Magnetic nanoparticles (MNPs) can work as temperature sensors to realize temperature measurement due to the excellent temperature sensitivity of their magnetization. This paper mainly reports on a performance optimization method of MNPs DC thermometry model. Firstly, by exploring the influencing factors of MNPs magnetization temperature sensitivity, it is found that the optimal excitation of the magnetic field to make the temperature sensitivity of MNPs reach their optimal value is, approximately, inversely proportional to the particle size of MNPs. Then, the temperature sensitivity of MNP magnetization is modulated by adding appropriate DC bias magnetic field in the original triangular wave excitation field, to optimize the original DC thermometry model based on MNP magnetization. The simulation results show that the temperature measurement performance of small-size MNPs can be significantly improved. In short, this paper optimizes the temperature measurement performance of the original DC thermometry model based on MNP magnetization and provides a new application idea for temperature measurement of small-size MNPs.
The Driving Path of Customer Sustainable Consumption Behaviors in the Context of the Sharing Economy—Based on the Interaction Effect of Customer Signal, Service Provider Signal, and Platform Signal
Authors: Wang Juying , Yu Xiaoqing
Published: March 2021

The sharing economy, based on collaboration, sharing, and innovation, has brought about a disruptive revolution in the transformation of the economy and provided a new operating mechanism for promoting sustainable consumption. Therefore, exploring which signals in the sharing economy can effectively stimulate customer consumption behaviors is of great significance. The research uses the signal-interpretation-response (I-I-R) model to build a research framework for customer sustainable consumption behaviors in the context of the sharing economy. With the help of web crawler technology, we captured customer online review data on Airbnb, the sharing accommodation platform, to study the driving path to interpret how multiple signals from different sources influence sustainable consumption behaviors. Regression research shows that the scores in the customer signal, the sustainable services provided in the service provider signal, the super-host certification in the platform signal, and the interactive effects of the three signals have a significant positive impact on customer sustainable consumption behaviors. Consequently, the increase of customer sustainable consumption behaviors improves sales performance. Furthermore, the fuzzy-set qualitative comparative analysis (fsQCA) found five configurations for customer sustainable consumption behaviors based on different property types. The research results provide a reference for strengthening customer sustainable consumption behaviors and improving the service quality of platforms and service providers.
Contribution of Renewable Energy Consumption to CO2 Emission Mitigation: A Comparative Analysis from a Global Geographic Perspective
Authors: Jia Junsong , Lei Jing , Chen Chundi , Song Xu , Zhong Yexi
Published: March 2021

Renewable energy consumption (REC) has an important significance in mitigating CO2 emissions. However, currently, few scientists have analyzed the underlying impact of REC from a global geographic perspective. Thus, here, we divide the world into seven regions to study this impact during the period 1971–2016 using the logarithmic mean Divisia index (LMDI). These regions were East Asia and the Pacific (EAP), Europe and Central Asia (ECA), Latin America and the Caribbean (LAC), Middle East and North Africa (MENA), North America (NA), South Asia (SA), and Sub-Saharan Africa (SSA). The results showed that ECA had the most obviously mitigating effect of −10.13%, followed by NA and MENA (−3.91% and −3.87%, respectively). Inversely, EAP had the largest driving effect of 4.12%, followed by SA (3.43%) and the others. Globally, REC had an overall mitigating contribution of −11.04% to total CO2 change. These results indicate that it is still important to exploit and utilize renewable energy, especially in presently developing or underdeveloped countries. Moreover, for some countries at a certain stage, their REC effects were negative, but, concurrently, their energy intensity effects were positive. These results show that some developing countries recently reduced carbon emissions only by extensively using renewable energy, not by enhancing energy-use efficiency. Finally, some policy implications for reducing CO2 in different countries are recommended.
Establishment of a Genetically Confirmed Breeding Colony of Mastomys natalensis from Wild-Caught Founders from West Africa
Authors: Safronetz David , Rosenke Kyle , Fischer Robert J. , LaCasse Rachel A. , Scott Dana P. , Saturday Greg , Hanley Patrick W. , Maiga Ousmane , Sogoba Nafomon , Schwan Tom G. , Feldmann Heinz
Published: March 2021

Mastomys natalensis are a ubiquitous and often dominant rodent across sub-Saharan Africa. Importantly, they are a natural reservoir for microbial pathogens including Lassa virus (LASV), the etiological agent of Lassa fever in humans. Lassa-infected rodents have been documented across West Africa and coincide with regions where annual outbreaks occur. Zoonotic transmission to humans most often occurs directly from infected rodents. Little is known about LASV infection kinetics and transmissibility in M.natalensis, primarily due to available animals. Here, we describe the establishment of a laboratory breeding colony of genetically confirmed M.natalensis from wild-captured rodents. This colony will provide a convenient source of animals to study LASV and other emerging pathogens that utilize M. natalensis in their enzootic lifecycles.
Calculation formula for determining the residual resource of agricultural equipment details
Authors: Kostomakhin M. N. , Voronov Ar. N.
Published: March 2021

When calculating the residual life of machine parts, it is advisable to use the relative value of the residual life, since the calculation of the relative value allows you to obtain a dimensionless value, to obtain a relative generalized estimate of the residual life of the main components and assemblies of complex machines, as well as groups of parts of the same name.
How Much Do Farmers Expect to Implement for Traceability? Evidence From a Double-Bound Choices Experiment of Vietnamese Shrimp Aquaculture
Authors: KHUU T.P. DONG , NGUYEN THI NGOC HOA , TRAN NGUYEN HAI NAM , SAITO YOKO , MATSUISHI TAKASHI
Published: March 2021

Traceability is considered the most important requirement for shrimp products exported to global markets. However, implementing traceability in shrimp-exporting countries is challenging because of limited production at the local supply chain and lack of financial welfare awareness. This study aims to investigate the expected farm-gate price for traceability implementation using a double-bound dichotomous choice experiment. The censored regression model is used to estimate the factors influencing the anticipated farm-gate price of shrimp farmers. The survey was conducted in Ca Mau Province, Vietnam, by interviewing 71 Penaeus monodon Fabricius, 1798, and 43 Penaeus vannamei Boone, 1931, farmers. To implement traceability, P. monodon farmers estimated the farm-gate price at 10.17 USD.kg-1 , while P. vannamei farmers expected 6.18 USD.kg-1 . Application of international quality assurance certifications, willingness to implement traceability, land used, culture methods, shrimp species, current farm-gate price, and variable costs affected the expected farm-gate price. The attractive anticipated farm-gate price compensated for the negative influence of applying international quality assurance certifications, indicating that the farmers were willing to implement traceability. This suggests that the application of certifications increased the ability to implement traceability in the shrimp supply chain. The attractive farm-gate price for certified shrimp products would enhance their willingness to implement the traceability of shrimp products.
Une innovation durable : la protection de la faune et de la flore dans la loi du 10 juillet 1976
Authors: Untermaier Jean
Published: March 2021

A sustainable innovation : the fauna and flora’s protection in the Law of 10 July 1976. Based on the concept of « biological heritage », the Law of 10 July 1976 established a full system for the protection of animal and plant species. When there are threatened or in decline or when there present a « special scientific interest » , they may be registered on a list drawn up by interministerial decree and then enjoy for an extended protection. This is a considerable step compared to the previous law, which only allowed the preservation of a few birds and mammals under the legislation on hunting. However, the 1976 system is not perfect and despite undeniable successes (large raptors, for example), it has not managed to stop the general collapse of biodiversity. In this context, its reform should be considered, maybe as a continuation of contemporary reflections on the status of animals. Nevertheless, considering the power of interests that are unfavorable to conservation (hunting in particular), an extreme caution is required.
Quelle effectivité pour les référés-environnement ?
Authors: Ballandras-Rozet Christelle
Published: March 2021

Les référés-environnement révèlent une effectivité textuelle contrariée par l’imperium juridictionnel. Les dispositions du Code de justice administrative et du Code de l’environnement facilitent le prononcé de mesures de suspension, au point de les rendre automatiques. L’urgence qui est exigée pour certains référés – en l’occurrence, les référés d’urgence -, est, dans ces cas, présumée ; la protection de l’environnement impliquant nécessairement cette notion. Or, le juge, en vertu de son pouvoir souverain d’appréciation, en limite l’automaticité en exerçant une analyse factuelle à la fois approfondie et restrictive qui le conduit à requalifier les conclusions du commissaire-enquêteur et à se prononcer au titre des référés de droit commun, alors même que la demande se fonde simultanément sur ceux-ci et les référés-environnement. Cette conception réductrice est renforcée par une position jurisprudentielle dogmatique dont il ressort que le juge, en vérifiant la présence de l’étude d’impact et en veillant au respect de l’intérêt général, peut s’opposer à la suspension de l’acte.
Interactions between Cytokines and Drugs in COVID-19 Potential Interactions between Increased Cytokines in COVID-19 and Drugs used to Treat COVID-19
Authors: ÖZTÜRK Tülün , ÇAVUŞOĞLU Tuğba , İNCİR Canet , TUNÇOK Yeşim
Published: March 2021

Abstract

During COVID-19 infection, virus and host cell interactions lead to the acute production of very strong immune mediators. The clinical status caused by damage throughout the body is mostly due to excessive pro-inflammatory cytokine production from virus-induced macrophages and granulocytes. Under infectious and inflammatory conditions, clinical and experimental studies have demonstrated that hepatic and extrahepatic cytochrome P450 (CYP) enzymes and carrier proteins responsible for drug metabolism are specifically regulated by many cytokines. Downregulation of these enzymes by cytokines can cause an elevation in plasma drug levels and/or lead to adverse drug reactions and/or toxicity. Based on the knowledge of cytokine-drug interactions occurring in the infection and inflammation stage, the aim of this review was to ascertain the influence of uncontrolled cytokine release on the metabolism of drugs used alone or in combination to treat COVID-19 patients and predict drug-drug interactions causing adverse effects.