bluuebunny/crossref_metadata_2025 huggingface dataset:
Comprehensive Representation of Tropical–Extratropical Teleconnections Obstructed by Tropical Pacific Convection Biases in CMIP6
Authors: Feng Xiaofang , Ding Qinghua , Wu Liguang , Jones Charles , Wang Huijun , Bushuk Mitchell , Topál Dániel
Published: July 2023

The central role of tropical sea surface temperature (SST) variability in modulating Northern Hemisphere (NH) extratropical climate has long been known. However, the prevailing pathways of teleconnections in observations and the ability of climate models to replicate these observed linkages remain elusive. Here, we apply maximum covariance analysis between atmospheric circulation and tropical SST to reveal two coexisting tropical–extratropical teleconnections albeit with distinctive spatiotemporal characteristics. The first mode, resembling the Pacific–North American (PNA) pattern, favors a tropical–Arctic in-phase (warm Pacific–warm Arctic) teleconnection in boreal spring and winter. However, the second mode, with a slight seasonal preference of summer, is manifested as an elongated Rossby wave train emanating from the tropical eastern Pacific that features an out-of-phase relationship (cold Pacific–warm Arctic) between tropical central Pacific SSTs and temperature variability over the Arctic (referred to as the PARC mode). While climate models participating in phase 6 of the Coupled Model Intercomparison Project (CMIP6) appear to successfully simulate the PNA mode and its temporal characteristics, the majority of models’ skill in reproducing the PARC mode is obstructed to some extent by biases in simulating low-frequency SST and rainfall variability over the tropical eastern Pacific and the climatological mean flow over the North Pacific during boreal summer. Considering the contribution of the PARC mode in shaping low-frequency climate variations over the past 42 years from the tropics to the Arctic, improving models’ capability to capture the PARC mode is essential to reduce uncertainties associated with decadal prediction and climate change projection over the NH.

Significance Statement

This study focuses on the skill of models in phase 6 of the Coupled Model Intercomparison Project (CMIP6) in simulating two leading observed Northern Hemisphere (NH) teleconnections that show distinctive spatial and temporal characteristics. The first one, the Pacific–North American (PNA) mode, exhibits a warm Pacific–warm Arctic pattern in boreal spring and winter, and the second one, the Pacific–Arctic (PARC) mode, features a cold Pacific–warm Arctic out-of-phase relationship. We find that models are skillful in simulating the PNA mode but not the PARC mode. This limitation may be rooted in unrealistic simulations of the mean state of winds and the low-frequency sea surface temperature variability in the tropical eastern Pacific. These biases call for caution when interpreting current models’ projections of extratropical circulations on multidecadal time scales.
Lecanemab
Authors: Levien Terri L. , Baker Danial E.
Published: July 2023

Each month, subscribers to The Formulary Monograph Service receive 5 to 6 well-documented monographs on drugs that are newly released or are in late phase 3 trials. The monographs are targeted to Pharmacy & Therapeutics Committees. Subscribers also receive monthly 1-page summary monographs on agents that are useful for agendas and pharmacy/nursing in-services. A comprehensive target drug utilization evaluation/medication use evaluation (DUE/MUE) is also provided each month. With a subscription, the monographs are available online to subscribers. Monographs can be customized to meet the needs of a facility. Through the cooperation of The Formulary, Hospital Pharmacy publishes selected reviews in this column. For more information about The Formulary Monograph Service, contact Wolters Kluwer customer service at 866-397-3433.
Digitalization of public administration in EU member states in times of crisis: the contributions of the national recovery and resilience plans
Authors: Profiroiu Constantin Marius , Negoiță Ciprian Ionuț , Costea Adrian Vladimir
Published: July 2023

This article explores, in a comparative manner, the state-of-play of digital transformation of public administration in EU Member States. Using a specific methodological toolkit that combines policy and statistical analysis for each EU Member State, this article evaluates the investments in the digitalization of public services, the use of broadband, the access to digital public services, the number of e-government users, the level of digital public services for citizens and businesses and open data. In our analysis, we will argue that the gaps and discrepancies in the field of digitalization of public administration, correlated with the indicators monitored in the Digital Economy and Society Index, have conditioned the EU Member States to design specific actions, measures and investments related to the national context.

Points for practitioners The gaps and discrepancies concerning the digitalization of public administration are analyzed and evaluated in relation to the state-of-play of digital transformation of public administration in EU Member States, correlated with the objectives and funding allocated to the digitalization pillar of the NRRP. The digitalization gap is measured by identifying and evaluating quantifiable indicators. Evaluations regarding the pillar of the digital transformation of public administration at national and regional levels are available, allowing comparative analyses to be carried out.
Experimental investigation and numerical modeling of mechanically alloyed Al-TiC composites
Authors: Habba Mohamed IA , Barakat Waheed S , Hamid FS
Published: July 2023

The present work studies the mechanical alloying, consolidation, evaluation, modeling, and optimization of the Al-TiC composites mixed at different milling times (MTs) of 6, 12, 24, and 48 h and reinforced with three TiC concentrations (3, 6, and 12 vol.%). The Al-TiC composites formed via the powder metallurgy method. The XRD of the mixed powder and the consolidated composites were investigated. Furthermore, density, wear, compressive strength, and hardness have been examined for the consolidated composites. Also, the worn surface of the wear-tested composites was studied utilizing SEM analysis. The response surface methodology (RSM) was involved to clarify the effects of mechanical alloying parameters of MTs and the TiC concentrations and their interaction towards achieving their optimum process factors to produce Al-TiC composites. The RSM results prove the applied factors’ importance in improving the consolidated composites’ properties. The optimization results show the optimum parameters to produce Al-TiC composites are 28.4 MTs and 12 vol.% TiC to produce Al-TiC composites with 304.4 ± 3 MPa compressive strength, 191.21 ± 2 HV hardness, 2.88 ± 0.008 g/cm3 density, and 9.7 ± 0.01 mg weight loss. The ANOVA analysis reveals that the suggested models can virtually expect the tested responses of density, hardness, compressive strength, and weight loss with a confidence level of over 90, 98, 95, and 95%, respectively.
Tales of Two Channels: Digital Advertising Performance Between AI Recommendation and User Subscription Channels
Authors: Dong Beibei , Zhuang Mengzhou , Fang Eric (Er) , Huang Minxue
Published: July 2023

Although in-feed advertising is popular on mainstream platforms, academic research on it is limited. Platforms typically deliver organic content through two methods: subscription by users or recommendation by artificial intelligence. However, little is known about the ad performance between these two channels. This research examines how the performance of in-feed ads, in terms of click-through rates and conversion rates, differs between subscription and recommendation channels and whether these effects are mediated by ad intrusiveness and moderated by ad attributes. Two ad attributes are investigated: ad appeal (informational vs. emotional) and ad link (direct vs. indirect). Study 1 finds that the recommendation channel generates higher click-through rates but lower conversion rates than the subscription channel, and these effects are amplified by informational ad appeal and direct ad links. Study 2 explores channel differences, revealing that the recommendation channel yields less source credibility and content control, reducing consumer engagement with organic content. Studies 3 and 4 validate the mediating role of ad intrusiveness and rule out ad recognition as an alternative explanation. Study 5 uses eye-tracking technology to show that the recommendation channel has lower content engagement, lower ad intrusiveness, and greater ad interest.
Constructivist and Transmissive Mentoring: Effects on Teacher Self-Efficacy, Emotional Management, and the Role of Novices’ Initial Beliefs
Authors: Burger Julian
Published: July 2023

Mentoring is acknowledged as an essential prerequisite for successful teacher induction, but its effectiveness may vary depending on the mentor’s quality of support and the mentee’s initial professional beliefs. Focusing on novice teachers’ self-efficacy and emotional management, this longitudinal study investigates how constructivist- and transmission-oriented mentoring approaches support beginning teachers’ professional development, and how these approaches interact with the novices’ initial beliefs about teaching and learning. The data stem from a sample of 138 beginning teachers who participated in an online survey during their second and third trimesters of practical training in Germany. Moderated regression analyses indicate positive effects of constructivist mentoring on teacher self-efficacy 6 months later, and an enhancing moderation effect of mentees’ mismatching, transmissive beliefs. Results neither support distinct effects of constructivist mentoring on novices’ emotional management nor associations between transmissive mentoring and the outcomes. Implications for mentoring research and practice are discussed.
Reducing Underage Drinking Through Visible Home Visits by Law Enforcement: An Efficacy Case Study Over 29 Months
Authors: George Michael D. , Holder Harold D. , McKenzie Paul N. , Faile Barry S. , Mueller Heather R.
Published: July 2023

This paper describes the development and impact of an underage drinking reduction program designed and implemented by a South Carolina county sheriff's office with assistance from the county coalition. In December 2017, high school surveys identified family and friends as the alcohol source 82.2% of the time. In Summer 2018, sheriff deputies began visiting with almost all high school seniors, i.e., 1,352 high school senior visits.

Deputies reminded parents to not provide alcohol to anyone under 21 years old. School surveys were conducted pre-program (December 2017), during (April 2018 and September 2018) and post-program (April 2020). Comparing the pre-effort results with post surveys found a 22.8% decline in 30-day drinking (p=.01) and a 23.5% decrease in binge drinking (p=.07). As described by Holder et al., the results provide the foundation for replication under controlled research conditions.
Disaster Extractivism: Latin America’s Extractive Shock Therapy in the Age of COVID-19
Authors: Artiga-Purcell James Alejandro , Chiasson-LeBel Thomas , Leiva Fernando , Watanabe-Farro Alejandra
Published: July 2023

Latin America faces a twin crisis. The spread of COVID-19 has become a health catastrophe and sent regional economies into recession, while governments’ increasing reliance on extractive development as a health and economic “cure” has compounded existing socio-environmental conflicts across the continent. An emergent “extractive savior” discourse aligns with political economic interests that have instrumentalized the pandemic to propel a new strain of disaster capitalism—disaster extractivism. Any socio-environmentally just response to COVID-19 must eschew the extractivist logic that underlies the pandemic and mainstream responses to it.

América Latina enfrenta una doble crisis. La propagación de COVID-19 se ha convertido en una catástrofe sanitaria y ha llevado a las economías regionales a la recesión, mientras que la creciente dependencia de los gobiernos del desarrollo extractivo como una "cura" sanitaria y económica ha agravado los conflictos socioambientales existentes en todo el continente. Un discurso emergente de "salvación extractiva" se alinea con los intereses económicos políticos que han instrumentalizado la pandemia para impulsar una nueva cepa del capitalismo desastroso: el extractivismo desastroso. Cualquier respuesta socioambientalmente justa al COVID-19 debe evitar la lógica extractivista que subyace a la pandemia y las respuestas generales a esta.
A study on nitrile rubber/polyvinyl chloride blend vulcanization kinetics with different fillers by using single isothermal rheograph
Authors: Dharmaraj Murali Manohar , Begum S. Shamshath , Chakraborty Bikash C.
Published: July 2023

An attempt has been made to establish a reasonably accurate microkinetics model for accelerated sulfur vulcanization of commonly used acrylonitrile rubber/polyvinyl chloride (NBR/PVC 70/30) blend (NVC73) from a single, isothermal rheograph data of torque versus time. The effect of three different types of fillers, such as pre-exfoliated organically modified montmorillonite (OMMT) clay, graphite (GRT) powder, and high abrasion furnace (HAF) carbon black (CB), were studied. The kinetics study was done with six solid-state reaction kinetics models. Among these, Sestak-Berggren (SB) equation was found to be the best model for the present compositions. The SB kinetic rate expressions were evolved after several iterations using empirical values of autocatalytic and non-autocatalytic orders of ‘ m’ and ‘ n’, respectively. The gum vulcanizate and OMMT clay-loaded compositions were found to have comparable conversion function f (α) and almost identical reaction rate constants at 150°C, under isothermal conditions. In comparison, HAF CB and GRT rate expressions differed from clay-loaded compositions. The validity of the reaction rate equations obtained was confirmed by comparison of plots for experimental and derived conversions with time.
Rolling bearing fault diagnosis under variable working conditions using deep convolutional fuzzy system
Authors: Zhu Keheng , Zhou Shunming , Chen Liang , Gu Bangping , Hu Xiong
Published: July 2023

This paper addresses the application of a deep convolutional fuzzy system (DCFS) for the fault diagnosis of rolling element bearings. The limitations of the conventional deep convolutional neural network (CNN) are the huge computational load of training the tones of parameters and the lack of interpretability for the corresponding parameters. In this paper, a DCFS-based bearing fault diagnosis method under variable working conditions is proposed. The DCFS on a high dimensional input space is a multilayer connection of many low dimensional fuzzy systems, which can overcome the computational and interpretability problems of the traditional CNN. Moreover, to improve the identification efficiency and diagnosis accuracy, the infinite feature selection (Inf-FS) algorithm is employed to select the most informative fault features. The proposed approach is experimentally demonstrated to be able to identify the different fault types and fault severities of rolling bearings under variable running states.
When Mindfulness is Insufficient: The Moderated Moderating Effects of Self-Harm and Negotiable Fate Beliefs on the Association Between Mindfulness and Adolescent Psychological Distress in Disasters
Authors: Zhang Yuchi , Wang Chunqian , An Yi , Jiang Xinrui
Published: July 2023

The coronavirus disease 2019 (COVID-19) pandemic has increased the risk of psychological distress among adolescents. Moreover, adolescents in 70 countries have suffered simultaneously from the COVID-19 pandemic and flood disasters. Research on the protective role of mindfulness on psychological distress is warranted; moreover, the practical needs arising from disasters require a deeper understanding of the potentially complex interplay between mindfulness and psychological distress. Using social–ecological systems theory, this study examined the moderating effects of self-harm and negotiable fate on the relationship between mindfulness and psychological distress in adolescents suffering from concurrent dual disasters (COVID-19 and flood disasters). High school adolescents ( N = 1679; 49.3% adolescent boys) in Zhengzhou, China, completed the Child and Adolescent Mindfulness Measure, Suicide Thoughts and Behaviors Checklist, Negotiable Fate Questionnaire, and Depression Anxiety Stress Scales-21. A three-way interaction model was developed. The results indicate that mindfulness has a significant negative relationship with psychological distress during disasters. Moreover, self-harm and negotiable fate significantly moderated the negative associations between mindfulness and psychological distress in adolescents enduring concurrent dual disasters (three-way interaction effects model). These findings highlight the significance of the interactions between different ecological system factors in the negative associations between mindfulness and psychological distress amid disasters.
Organic matter accumulation mechanisms and source rock potential of the Mesoproterozoic Xiamaling Formation, Yanliao Basin, North China
Authors: Jiang Ziwen , Cai Chunfang
Published: July 2023

The Mesoproterozoic Xiamaling Formation (∼1.4 Ga) is considered to be a set of promising strata for shale oil and gas exploration and production in the Yanliao Basin, North China Craton. This study aimed to investigate the organic matter accumulation mechanism, and hydrocarbon generation and expulsion characteristics of the Xiamaling Formation, using various methods, including scanning electron microscopy, rock-eval pyrolysis, and elemental geochemistry. Multiple geochemical proxies indicate that Unit 3—Unit 1 of the Xiamaling Formation was deposited in a climate that alternated between highly humid and semiarid conditions, with the strong-to-weak terrigenous influx. The redox conditions of bottom water were undulatory oxic in Unit 3 and the upper part of Unit 1, but anoxic in Unit 2 and the lower part of Unit 1. Sulfurization of organic matter was the main reason for the high TOC content in Unit 3. However, the high TOC content in Unit 2 and the lower part of Unit 1 was caused by an oxygen-deficient water column. Unit 2 and the lower part of Unit 1 exhibit a significant shale oil potential owing to low maturity, high hydrogen index (HI) values, and prevalence of type Ⅰ, II1, and II2 kerogens.
“An out gay man in the parliament”: New aspects in the study of LGBTQ politicians’ media coverage
Authors: Greenwald Gilad , Haleva-Amir Sharon , Kama Amit
Published: July 2023

This study identifies how three prominent Israeli online newspapers frame gay Members of Knesset (Israeli parliament) and cabinet ministers. 2019 was chosen since the number of gay MKs reached a historic milestone of representation. The study employed a mixed-methods design, combining descriptive statistics, based on a quantitative content analysis, with a thematic qualitative analysis. 1015 retrieved news items constituted the initial database. They were divided into two categories: “Gay relevant” (items explicitly referring to, or mentioning the politician’s sexual orientation); or “Gay irrelevant” (all other items), to thematically focus on the Gay relevant items ( N = 159). Six themes were then identified: Novelty; LGBTQ Political Representation; Private Sphere; Homophobia; Community Recognition and Rights; and Incongruity. Findings revealed that elite newspaper coverage is similar to popular ones; cabinet ministers’ framing is more neutral compared to junior MKs; and liberal MKs are framed differently than conservative ones.
Media practice and class-making: The anticipation of stigma and the cultural middle-class habitus
Authors: Lindell Johan , Kas Aleksandra Dominika
Published: July 2023

The relationship between media practices and social inequality has been studied within a range of sub-disciplines in media and communication studies and cultural sociology. In various, more or less direct, ways these studies point to the fact that habitus – the socially formed class specific relations to the social world – generates certain tastes, lifestyles, practices and preferences. When social groups form relatively distinct media practices, and distance themselves from the practices of other groups, they reproduce their social position, and ‘make’ their class. By analysing in-depth interviews with members of an emerging cultural middle-class, this study shows how class-making also manifests in the ways in which people expect that others would ‘look down’ on their media practices. By anticipating stigma from imagined others, the cultural middle-class stays in line with class-specific lifestyles and media practices, thus cementing their distinct character in the social space.
Clinical efficacy of ZelanteDVT™ catheter rheolytic thrombectomy in the single-session treatment of patients with subacute deep venous thrombosis
Authors: Li Da , Zhang Xiaosong , Wang Yusheng , Tang Hao , Huang He , Huang Xiaomin , Zhang Honggang
Published: July 2023

Objective

To evaluate the clinical efficacy and safety of novel ZelanteDVT™ catheter rheolytic thrombectomy in the single-session endovascular management of subacute deep venous thrombosis (DVT).

Methods

A retrospective study was performed on 31 patients with subacute DVT who underwent ZelanteDVT™ catheter rheolytic thrombectomy. Procedure data, associated complications, and venous patency score were recorded. The deep venous patency and post-thrombotic syndrome (PTS) rate were assessed in all patients during follow-up visits.

Results

After procedure, 19.4% (6/31) patients improved to grade III thrombus removal, while the remaining patients improved to grade II. Significant iliac vein compression syndrome was identified in 54.8% (17/31) patients, and 82.4% (14/17) of them received stent implantation. No serious procedure-related complications occurred. The median follow-up time was 13 months. The primary patency rate at 12 months was 83.87%, and the incidence of PTS was 19.35%.

Conclusion

This novel rheological thrombectomy catheter seems to have a promising application prospect for single-session treatment of subacute DVT.
Capturing Classroom Talk With the Low- Inference Discourse Observation Tool: A Validation Study
Authors: LaRusso Maria D. , Al-Adeimi Shireen , Kim Ha Yeon , Harbaugh Allen G. , O'Connor Catherine
Published: July 2023

This paper introduces the LIDO, or the Low-Inference Discourse Observation tool, that captures discourse moves produced by students and teachers in whole-classroom discussions. Coding methods are described, followed by analyses that explore validity of the LIDO through correlations among LIDO-coded discourse moves and between LIDO scores and scores on the Instructional Support domain of the Classroom Assessment Scoring System-Secondary, utilizing 643 audio-recorded classroom lessons. Observations were conducted in fourth through seventh grade urban classrooms, including English Language Arts, Mathematics, Science and Social Studies. Rates of teacher and student discourse moves correlated with each other and with CLASS scores in expected ways, providing evidence of internal and convergent validity. Implications for use in research are discussed, including specific advantages of this new approach, such as the capacity to tease apart teacher behavior from student behavior in the context of classroom interactions.
Marketers as Appropriate Marital Partners: Historical Perspectives and Future Prospects
Authors: Godwin Lynn R.
Published: July 2023

This paper considers the current value of three reflective papers published in the Journal of Marketing by Richard N. Farmer in 1967, 1977, and 1987. Farmer examined the global impact of marketing on war, peace, healthcare, education, and societal well-being. Through the utilization of a stylistic homage, Farmer's perspectives on marketing are reviewed and re-examined. For better or for worse, current societal (and marital) implications are discussed.
Symmetry as an Inter-Cultural Feature Constituting Beauty: Implicit and Explicit Beauty Evaluation of Visual Symmetry in Japan
Authors: Leder Helmut , Mikuni Jan , Kawabata Hideaki , Rosenberg Raphael
Published: July 2023

Symmetry has been recognized as one of the most important visual features to predict aesthetic preferences and was discussed as a potentially universal feature of beauty judgments. Recent studies have challenged such universality claims, by showing that art experts prefer asymmetric stimuli in explicit evaluations, suggesting that artistic training might modify the preference for symmetry. In the present study, we examine whether cultural habituation might also influence beauty judgments in regard to symmetry in abstract visual patterns. Given the traditional preference for asymmetry in Japanese art and design, we tested if Japanese participants ( N = 31) evaluate symmetric abstract visual patterns as more beautiful than asymmetric ones in explicit and implicit (IAT) tasks. We found that Japanese participants clearly evaluated symmetric stimuli as more beautiful than asymmetric ones. We conclude that cultural habituation with asymmetry—in contrast to artistic training—did not cause higher beauty ratings for asymmetry.
ViF-GTAD: A new automotive dataset with ground truth for ADAS/AD development, testing, and validation
Authors: Haas Sarah , Solmaz Selim , Reckenzaun Jakob , Genser Simon
Published: July 2023

A new dataset for automated driving, which is the subject matter of this paper, identifies and addresses a gap in existing similar perception datasets. While most state-of-the-art perception datasets primarily focus on the provision of various onboard sensor measurements along with the semantic information under various driving conditions, the provided information is often insufficient since the object list and position data provided include unknown and time-varying errors. The current paper and the associated dataset describe the first publicly available perception measurement data that include not only the onboard sensor information from the camera, Lidar, and radar with semantically classified objects but also the high-precision ground-truth position measurements enabled by the accurate RTK-assisted GPS localization systems available on both the ego vehicle and the dynamic target objects. This paper provides insight on the capturing of the data, explicitly explaining the metadata structure and the content, as well as the potential application examples where it has been, and can potentially be, applied and implemented in relation to automated driving and environmental perception systems development, testing, and validation.
Current practices of follow-up programs for childhood cancer survivors in Italy
Authors: Terenziani Monica , Tozzi Alberto Eugenio , Diaco Laura , Biasin Eleonora , Cattoni Alessandro , Croci Ileana , Fraschini Donatella , Giorgiani Giovanna , Haupt Riccardo , Muraca Monica , Pillon Marta , Sironi Giovanna , Valsecchi Maria Grazia , Mastronuzzi Angela
Published: July 2023

Introduction

Quality of life in childhood cancer survivors is largely affected by survivorship care and transition from treatment to long-term follow-up (LTFU). Referring to evidence-based recommendations, we wanted to evaluate LTFU care for survivors through a survey among the Italian Association for Pediatric Hematology-Oncology (AIEOP) centers. The project aimed to evaluate the availability of services in Italy, investigate strengths and weaknesses, analyze improvements of awareness in the field, and identify the gaps that need to be addressed by different centers.

Methods

Together with the family representatives, on behalf of AIEOP’s Late Effects Working Group, we developed a questionnaire on assisting childhood cancer survivors. All AIEOP centers received one questionnaire including information on local health system organizations; LTFU for childhood cancer survivors; services for adult survivors of childhood cancer; information provided to survivors/caregivers and care plan delivery.

Results

Forty-eight AIEOP centers were contacted and 42 replied, with a response rate of 87.5%. The majority of respondents confirmed their interest in assisting patients with a survivorship care plan (95.2%), regardless of a clinic or dedicated staff.

Discussion

This is the first overview of LTFU in Italy, which provides detailed results at national levels, prompting consideration of improvements in the last decade. Although there is a high level of interest in survivorship care, many centers lack resources to implement such programs. The identification of these challenges is useful for planning future strategies.
Chlamydia muridarum infection causes bronchointerstitial pneumonia in NOD.Cg-PrkdcscidIl2rgtm1Wjl/SzJ (NSG) mice
Authors: St Jean Samantha C. , Ricart Arbona Rodolfo J. , Mishkin Noah , Monette Sébastien , Wipf Juliette R. K. , Henderson Kenneth S. , Cheleuitte-Nieves Christopher , Lipman Neil S. , Carrasco Sebastian E.
Published: July 2023

The murine bacterial pathogen Chlamydia muridarum (Cm) has been used to study human Chlamydia infections in various mouse models. CD4+ T-cells, natural killer cells, and interferon-gamma (IFN-γ)–mediated immunity are important to control experimentally induced Cm infections. Despite its experimental use, natural infection by Cm has not been documented in laboratory mice since the 1940s. In 2022, the authors reported the discovery of natural Cm infections in numerous academic institutional laboratory mouse colonies around the globe. To evaluate the impact of Cm infection in severely immunocompromised mice, 19 NOD.Cg- Prkdcscid Il2rgtm1Wjl/SzJ (NSG) mice were cohoused with Cm shedding, naturally infected immunocompetent mice and/or their soiled bedding for 4 weeks and subsequently euthanized. Clinical disease, characterized by lethargy, dyspnea, and weight loss, was observed in 11/19 NSG mice, and 16/18 NSG mice had neutrophilia. All mice exhibited multifocal to coalescing histiocytic and neutrophilic bronchointerstitial pneumonia (17/19) or bronchiolitis (2/19) with intraepithelial chlamydial inclusions (CIs). Immunofluorescence showed CIs were often associated with bronchiolar epithelium. CIs were frequently detected by immunohistochemistry in tracheal and bronchiolar epithelium (19/19), as well as throughout the small and large intestinal epithelium without lesions (19/19). In a subset of cases, Cm colonized the surface epithelium in the nasopharynx (16/19), nasal cavity (7/19), and middle ear canal (5/19). Endometritis and salpingitis with intraepithelial CI were identified in a single mouse. These findings demonstrate that Cm infection acquired through direct contact or soiled bedding causes significant pulmonary pathology and widespread intestinal colonization in NSG mice.
Symptoms associated with headache in youth
Authors: Patterson Gentile Carlyn , Aguirre Geoffrey K. , Hershey Andrew D. , Szperka Christina L.
Published: July 2023

Objective

To determine the underlying relationships between a broad range of headache-associated symptoms and how they relate to headache burden.

Background

Symptoms associated with head pain inform classification of headache disorders. However, many headache-associated symptoms are not included in the diagnostic criteria, which is largely based on expert opinion. Large symptom databases can assess headache-associated symptoms irrespective of pre-existing diagnostic categories.

Methods

We conducted a large single-center cross-sectional study on youth (6–17 years old) assessing patient-reported outpatient headache questionnaires between June 2017 and February 2022. Multiple correspondence analysis, an exploratory factor analysis, was applied to 13 headache-associated symptoms.

Results

6662 participants (64% female; median age 13.6 years) were included. Multiple correspondence analysis dimension 1 (25.4% of the variance) captured the absence or abundance of headache-associated symptoms. A greater number of headache-associated symptoms correlated with greater headache burden. Dimension 2 (11.0% of the variance) revealed three symptom clusters: (1) cardinal features of migraine (light, sound, and smell sensitivity, nausea, and vomiting), (2) nonspecific global neurologic dysfunction symptoms (lightheadedness, trouble thinking, blurry vision), (3) vestibular and brainstem dysfunction symptoms (vertigo, balance problems, ear ringing, double vision).

Conclusion

Assessing a broader range of headache-associated symptoms reveals clustering of symptomatology and a strong relationship with headache burden.
The Resolution of Kaplan Fiber Injuries Is Observed in a Majority of Cases at 9 Months After Acute Primary Anterior Cruciate Ligament Reconstruction: A Radiological Study
Authors: Lord Breck R. , Devitt Brian M. , Hookway Samuel R. , Klemm Haydn J. , Webster Kate E. , Whitehead Timothy S. , Feller Julian A.
Published: July 2023

Background:

The natural history of Kaplan fiber (KF) injuries after acute primary anterior cruciate ligament (ACL) reconstruction (ACLR) remains unknown.

Purpose/Hypothesis:

The purpose of this study was to evaluate the temporal change in the magnetic resonance imaging (MRI) appearance of the KF complex after acute primary ACLR. It was hypothesized that KF injuries would resolve with time.

Study Design:

Case series; Level of evidence, 4.

Methods:

A retrospective MRI analysis was conducted on 89 patients with ACL-injured knees to assess the change in the radiological appearance of KFs after primary ACLR. Patients who had undergone index MRI and ACLR within 90 days of the injury and further MRI at 9 months after surgery were included. Diagnostic criteria to identify radiological evidence of a KF injury and its subsequent resolution were applied, including the presence of high signal intensity on fluid-sensitive sequences, which is indicative of a pathological process radiologically. The proximity of KFs to the femoral cortical suspensory device (CSD) was noted on MRI scans and quantified in millimeters.

Results:

A KF injury was identified in 30.3% (27/89) of patients, with isolated high signal intensity observed in an additional 18.0% (16/89). At 9 months, MRI evidence of the reconstitution of the KF complex was found in 51.9% (14/27) of patients, with persistent discontinuity in the remaining patients (13/27). All patients (16/16) with isolated high signal intensity had complete resolution on repeat MRI scans. KF thickening was observed in 26.1% (12/46) of patients with previously healthy KFs and in 25.0% (4/16) with isolated high signal intensity. The CSD was positioned in close proximity (≤6 mm) to the center of the KF attachment in 61.8% (55/89) of patients, and this was associated with increased rates of KF thickening.

Conclusion:

The KF injury resolved radiologically in over half of the patients at 9 months after acute primary ACLR. High signal intensity in the region of the KFs on index MRI scans resolved in all cases, with evidence of residual KF thickening in only one-quarter of cases on repeat MRI scans, equivalent to the rate in those with healthy KFs. As such, it is not advisable to use high signal intensity on preoperative MRI scans as the sole criterion for the diagnosis of a KF injury. The position of the CSD after ACLR was intimately related to the KF attachment in the majority of patients, which was associated with KF thickening on postoperative MRI scans.
Defining the Borderline Dysplastic Hip: High Variability in Acetabular Coverage and Femoral Morphology on Low-Dose Computed Tomography
Authors: Graesser Elizabeth A. , Schwabe Maria T. , Clohisy John C. , Nepple Jeffrey J.
Published: July 2023

Background:

Borderline acetabular dysplasia is commonly radiographically defined as a lateral center-edge angle (LCEA) of 20° to 25°. While the variability of plain radiographic assessment of this population has been reported, an understanding of the variability of 3-dimensional (3D) hip morphology remains to be better defined.

Purpose:

To investigate the variability of 3D hip morphology present on low-dose computed tomography (CT) in the setting of symptomatic borderline acetabular dysplasia and to determine if plain radiographic parameters correlate with 3D coverage.

Study Design:

Cohort study (diagnosis); Level of evidence, 2.

Methods:

A total of 70 consecutive hips with borderline acetabular dysplasia undergoing hip preservation surgery were included in the current study. Plain radiographic evaluation included LCEA, acetabular inclination, anterior center-edge angle (ACEA), anterior wall index (AWI), posterior wall index (PWI), and alpha angles on anteroposterior, 45° Dunn, and frog-leg views. All patients underwent low-dose pelvic CT for preoperative planning, which allowed detailed characterization of 3D morphology relative to normative data. Acetabular morphology was assessed with radial acetabular coverage (RAC) calculated according to standardized clockface positions from 8:00 (posterior) to 4:00 (anterior). Coverages at 10:00, 12:00, and 2:00 were classified as normal, undercoverage, or overcoverage relative to 1 SD from the mean of normative RAC values. Femoral morphology was assessed with femoral version, alpha angle (measured at 1:00 increments), and maximum alpha angle. Correlation was assessed with the Pearson correlation coefficient ( r).

Results:

Lateral coverage (12:00 RAC) was deficient in 74.1% of hips with borderline dysplasia. Anterior coverage (2:00 RAC) was highly variable, with 17.1% undercoverage, 72.9% normal, and 10.0% overcoverage. Posterior coverage (10:00 RAC) was also highly variable, with 30.0% undercoverage, 62.9% normal, and 7.1% overcoverage. The 3 most common patterns of coverage were isolated lateral undercoverage (31.4%), normal coverage (18.6%), and combined lateral and posterior undercoverage (17.1%). The mean femoral version was 19.7°± 10.6° (range, −4° to 59°), with 47.1% of hips having increased femoral version (>20°). The mean maximum alpha angle was 57.2° (range, 43°-81°), with 48.6% of hips having an alpha angle ≥ 55°. The ACEA and AWI were poorly correlated with radial anterior coverage ( r = 0.059 and 0.311, respectively), while the PWI was strongly correlated with radial posterior coverage ( r = 0.774).

Conclusion:

Patients with borderline acetabular dysplasia demonstrate highly variable 3D deformities, including anterior, lateral, and posterior acetabular coverage; femoral version; and alpha angle. Plain radiographic assessments of anterior coverage are poorly correlated with anterior 3D coverage on low-dose CT.
Clastogenic, aneugenic, and tubulin polymerization properties of di-(2-ethylhexyl) phthalate and dibutyl phthalate
Authors: Javaji Kalpana , Mamilla Jhansi , Deshpande Shruti S , Kanaka Raju Y , Amanchy Ramars , Misra Sunil
Published: July 2023

Phthalate compounds were found to disrupt the endocrine system and alter transcriptomes during human embryonic development. In our previous work, we have isolated and reported two such phthalates di-(2-ethylhexyl) phthalate (DEHP) and dibutyl phthalate (DBP) from Brevibacterium mcbrellneri bacteria and evaluated their bioactive properties. Naturally derived phthalates might be less toxic compared with synthesized molecules. We have investigated biologically isolated phthalates to understand the possible genotoxic effects in mice and further investigated in silico binding and polymerization of β-tubulin. Three sub-lethal concentrations of DEHP (150 μM, 175 μM, and 200 μM) and DBP (10 μM, 15 μM, and 30 μM) were studied. The results showed that the phthalates were found to be highly genotoxic in nature. However, the pattern of genotoxic effects was not found to be dose-dependent in the induction of chromosome aberrations (CA), micronuclei (MN), and changes in the mitotic index (MI) in cells. In silico studies of phthalates on polymerization of β-tubulin suggested that both DBP and DEHP were able to interact with the hydrogen bonds and make strong van der Waals interactions with β-tubulin thereby possibly causing destabilization of microtubule network. Our study suggests that these phthalates might be playing an important role in normal cell division thereby showing highly genotoxic effects.
The 1990 Revolution on Granite: Lessons from the First Maidan
Authors: Codogni Paulina
Published: July 2023

This article analyses the Ukrainian Revolution on Granite from two perspectives—on one hand as a starting point for Ukraine’s independence aspirations, and on the other as a prototype for subsequent Ukrainian revolutions. This Revolution constitutes an example of an event whose significance was discovered many years later. Although it was partially successful, and more importantly it should be treated as one of the milestones on the road to Ukraine’s independence, until the second decade of the twenty-first century it was assigned marginal significance and almost ignored as a research subject. This article searches for the basic factors of the Revolution’s success, based on the methodology provided by civil resistance theory and thus concentrating on its internal factors, especially on its objectives, strategy, and methods of struggle. One of the main purposes is to analyze the sources of experiences from which the leaders of the protests drew. The Revolution on Granite is also presented as the inaugural event of a new chapter in the tradition of protests in Ukraine by introducing new elements. Although later protests, especially the Orange Revolution (2003) and the Euromaidan (2013–2014), received inspiration from many symbols and experiences of other countries, the thread of the Ukrainian tradition became permanent, even though it was subject to changes.
Juveniles Accessing Mental health Services: A Novel Approach to Enhance Mental Health Among Vulnerable Adolescents
Authors: Srinivasan Shiva Prakash , Behra Aloka Datta , Arumugam Chiranjeevi , Panda Protush , E. Rangeela , Nayak Smriti Smitha , Ramachandran Padmavati
Published: July 2023

Background:

As a signatory of the United Nations Commission on Child Rights, India has enacted laws and policies to protect the child’s interests. The Juvenile Justice Act of 2015 addresses the needs and well-being of the most vulnerable children, including those who do not have anyone to care for or have experienced a traumatic upbringing and those who are allegedly in conflict with the law. No research from India addresses these vulnerable children’s mental health and well-being. The current paper describes a pilot project to create mental health awareness and improve children’s care access in India’s Juvenile Justice System (JJS).

Methods:

Permission was obtained from appropriate governmental agencies in Odisha and Tamil Nadu and Child Care Institutions (CCIs) that consented to participate. A co-creation model was utilized to create youth-friendly spaces and methods to deliver mental health literacy for all stakeholders and access to care.

Results:

Seven CCIs and 278 children across two states participated in the implementation of the project. 37.8% of the children had resided for less than six months and 34.5% for more than two years in the current CCI. Of the various adverse childhood experiences, neglect was the highest at 76.3% followed by parental issues at 32%.

Conclusions:

Children in the JJS have many risk factors predisposing them to develop mental health issues. This unique pilot project describes implementing a codesigned and co-created model of delivery of mental health literacy and access to care to this vulnerable group of children.
Efficacy of combining intravenous and topical dexamethasone against postoperative pain and function recovery after total knee arthroplasty: A prospective, double-blind, randomized controlled trial
Authors: Wu Changjun , Luo Defa , Zhu Yu , Zhao Qingyuan , Wang Jian , Dai Yunlei
Published: July 2023

Background

Dexamethasone is a corticosteroid with powerful anti-inflammatory effects. This study aimed to explore whether combining intravenous and topical dexamethasone could improve postoperative pain, swelling, and function recovery after total knee arthroplasty (TKA).

Methods

In this prospective, double-blind, randomized controlled study, 90 patients undergoing primary unilateral TKA were randomized into a dexamethasone group, which received dexamethasone (10 mg) by periarticular infiltration during surgery, as well as intravenous dexamethasone (10 mg) before tourniquet release and at 12 h postoperatively; or a control group, which received equal volumes of isotonic saline instead of dexamethasone. The primary outcome was postoperative pain, as assessed on the visual analogue scale (VAS). Secondary outcomes were postoperative consumption of morphine hydrochloride for rescue analgesia, postoperative swelling ratio of the thigh, knee, and tibia; functional recovery in terms of total range of motion (ROM) of knee and daily ambulation distance; postoperative inflammation biomarkers levels of C-reactive protein and interleukin-6; and postoperative complications.

Results

Resting VAS scores at postoperative 6, 12, and 24 h, and VAS scores during motion at postoperative 2, 6, 12, and 24 h were significantly lower in the dexamethasone group. The dexamethasone group also showed significantly less morphine consumption during the first 24 h after surgery and cumulatively during hospitalization, milder limb swelling at 24 and 48 h postoperatively, greater flexion and total ROM on postoperative day 1, and longer ambulation distance on postoperative days 1 and 2, and lower levels of inflammatory biomarkers on postoperative days 1 and 2. The dexamethasone group had significantly lower incidence of postoperative nausea and vomiting.

Conclusion

Compared with placebo, the combination of intravenous and topical dexamethasone can reduce pain, swelling, and inflammation after TKA, it also can improve functional recovery and reduce the incidence of postoperative nausea and vomiting.
Exploring Whole-Person Education Reform From Principals Perspective on High-Stakes Testing
Authors: Zhang Wei
Published: July 2023

Whole-person education is undeniable and indispensable for student benevolence and lifelong building. However, the high test score is the central issue in Chinese education. The purpose of this descriptive qualitative inquiry is to explore the high-test score issue by analyzing principals’ experiences in advocating the whole-person education in leading the school reform in China. A total of 12 participants of principals ( N = 12) were employed in this study. There are six female ( N = 6) and six male ( N = 6) principals from the six private ( N = 6) and public ( N = 6) schools in Beijing through semi-structural and open-ended interview protocols. This study found that principals face three major challenges, including (1) high test score causes distrust, unfairness, and separation between school stakeholders, (2) high test score causes academic pressure, and (3) high test score limits student competency and educators’ academic freedom. This study found that principals use three major strategies to form a school reform and student development, including (1) communication for whole-person education, (2) correlation between the whole-person education and student individual career plan, and (3) pathway from high school to college through cooperation project. Finally, the proposed study of using a basic qualitative research inquiry through semi-structural and open-ended interviewing with a total of 60 participants, including principals ( N = 12), teachers ( N = 12), parents ( N = 12), students ( N = 12), and superintendents ( N = 12), would be employed to investigate what challenges the schools face, how the schools should be, and what strategies should implement for lifelong student learning, suggested.