bluuebunny/crossref_metadata_2025 huggingface dataset:
PEMBUATAN LUBANG RESAPAN BIOPORI DAN PUPUK KOMPOS CAIR DARI SAMPAH DI RW IX, KELURAHAN KALIREJO, KECAMATAN LAWANG, KABUPATEN MALANG
Authors: Wijaya Sugeng Agung , Soebiyakto Gatot , Ma'sumah Mufidatul
Published: June 2020

Secara umum masyarakat RW 09 Kelurahan Kalirejo telah mampu untuk mengembangkan potensi lingkungan sekitar, hal ini dibuktikan dengan adanya kelompok masyarakat yang berupaya mengembangkan pengelolaan limbah sampah non-organik yang sudah terstruktur dengan baik. Pemberdayaan serta pengolahan sampah baik sampah organik maupun anorganik merupakan salahsatu masalah yang tidak asing lagi di tengah masyarakat. Dalam hal ini, berdasarkan hasil survei dikawasan RW 09, kelompok 3 menemukan bahwa pengolahan sampah terutama sampah organik diRW 09 ini dirasa kurang dimnfaatkan maksimal pengolahannya. Banyak dari sebagian masyarakatkurang peduli terhadap keadaan serta kelestarian di lingkungan sekitar berupa resapan air. Pembuatan Lubang Resapan Biopori (LRB) dan pupuk kompos cair dari sampah di RW 09 Kelurahan Kalirejo, Kecamatan Lawang, Kabupaten Malang dapat menambah jumlah resapan air dan mendapatkan manfaat sampah yang selama ini kurang digali. Sehingga nantinya, sumber air pada waktu kemarautetap besar, dan tanaman sekitar rumah menjadi lebih subur karena  endapatkan pupuk kompos cair.
Informationsaufbereitung für Smart Devices
Authors: Brandstätter Tobias Claus , Lossie Karl , Schmitt Robert H.
Published: June 2020

Kurzfassung

Der Einsatz von Smart Devices in der Produktion birgt großes Potenzial, jedoch hindern die Heterogenität der verfügbaren Hard- und Software und das Fehlen von Richtlinien zur Informationsgestaltung eine umfangreiche Nutzung. Deshalb werden im Forschungsprojekt DAISY – Device- und kontextabhängige Informationsverdichtung für Werker-assistenzsysteme – Empfehlungen und Regeln für die Informationsdarstellung auf Smart Devices im Produktionsbereich erforscht und die Ergebnisse in einem Demonstrator präsentiert.
Modelle als Grundlage für den Digitalen Zwilling
Authors: Langlotz Pascal , Glatt Moritz , Sousa Fábio J. P. , Aurich Jan C.
Published: June 2020

Kurzfassung

Digitale Zwillinge bilden Eigenschaften und Zustände von realen Systemen digital ab. Dabei analysieren sie auf Basis relevanter Daten und Modelle das reale System und geben optimierte Daten an das reale System zurück. Grundlage hierfür sind physikalische und datengetriebene Modelle, welche jeweils charakteristische Vor- und Nachteile aufweisen. Die zielgerichtete Integration beider Techniken erlaubt eine umfassende Abbildung, Analyse und Steuerung von Cyber-Physischen Produktionssystemen im Kontext von Industrie 4.0.
Verbreitungsgrad von Supply-Chain-Management-Methoden
Authors: Wagner Kristin , Pötters Patrick , Leyendecker Bert
Published: June 2020

Kurzfassung

Eine Supply Chain kann mit vielen verschiedenen Methoden koordiniert werden. Jedoch ist es schwierig für Unternehmen, aus der Vielzahl der Methoden die richtige auszuwählen. Es existiert noch kein Überblick darüber, welche Methoden in der Literatur und in der Praxis am meisten verbreitet bzw. bekannt sind. Daher wird der Verbreitungsgrad von achtzehn ausgewählten Supply-Chain-Management-Methoden in der Literatur sowie in der deutschen Industrie untersucht und daraus zwei Hitlisten erstellt.
Effektives Wertstromdesign 4.0
Authors: Michalicki Mathias , Büttner Konstantin , Schneider Markus
Published: June 2020

Kurzfassung

Die fortschreitende Digitalisierung der Produktion (Industrie 4.0) führt zu immer mehr Daten und damit auch zu stetig wachsender Menge an Informationen. In der Praxis zeigt sich oft, dass sich der Informationsbedarf, das Informationsangebot und die Informationsnachfrage nicht decken. Dadurch entsteht informationslogistische Verschwendung. Um die damit verbundenen Kosten zu reduzieren, werden fünf wesentliche Schritte für ein effektives Informations-system für die Produktion und Logistik von Unternehmen aufgezeigt.
Fabrication and characterization of Yb-doped Y2O3 powders and thin films
Authors: Kaya Elif Emil , Ünal Fatma , Kazmanlıa Kürşat , Gürmena Sebahattin
Published: June 2020

Yttrium oxide (Y2O3) and ytterbium (Yb)-doped Y2O3 particles were synthesized via the sol-gel method from the aqueous solution of their nitrate salts. The synthesized powders were then deposited on Corning glass substrates using an electron beam evaporation technique to examine the growth morphology of the thin films. The effect of the Yb dopant concentration on the microstructure and morphology of the Y2O3 powders and thin films was investigated using various characterization techniques. The synthesized powders and fabricated thin films have body-centered cubic structures with space group Ia-3. Based on the X-ray peak broadening, crystallite size and lattice parameters were evaluated with the Williamsom-Hall and Cohen-Wagner methods. The lattice parameter and crystallite size decrease with increasing Yb concentration. The intensities of the Raman peaks decrease due to microstructural disorder caused by the increase in the Yb dopant concentration. The band gap values of the powders also decrease depending on the dopant concentration, similar to the lattice parameter and crystallite size. While the synthesized powders have a sponge-like morphology, they exhibit different morphological structures depending on the dopant concentration when converted into thin films.
Targeting UCP2 Suppresses the FAK Signaling and Progression of Human Head and Neck Cancer Cells
Authors: Zhao Yunfeng , Nathan Cherie Ann , Zhang Chunjing , Du Hongyan , Panchatcharam Manikandan , Miriyala Sumitra , Zhao Yunfeng
Published: June 2020

Background: New adjuvant therapies for human head and neck (H&N) cancer to improve the quality of
life of the patients are in great demand. Our early studies have demonstrated that uncoupling protein 2
(UCP2) is upregulated in the tumor tissues of H&N cancer compared to the adjacent normal tissues;
however, the role of UCP2 in H&N cancer has not been studied.
Objective: In this manuscript, we aim to examine whether UCP2 contributes to H&N cancer progression
in vitro.
Methods: We generated UCP2 stable knockdown H&N cancer cells and detected the effects of UCP2
inhibition on cell proliferation, migration, invasion, 3D spheroid formation, and the sensitivity to a chemodrug treatment.
Results: Knockdown of UCP2 suppressed the progression of H&N cancer in vitro, which might be mediated
via the following mechanism: 1) increased the G1 phase whereas decreased the S phase of the cell cycle,
which could be mediated by suppression of the G1/S regulators including CDK4/6 and cyclin D1. 2)
Decreased mitochondrial oxygen consumption, ATP production, and lactate formation, which is consistent
with the downregulation of c-Myc. 3) FAK may serve as the upstream signaling molecule, and its action
was mediated by Akt and ERK.
Conclusions: Our studies first demonstrate that targeting UCP2 may suppress H&N cancer progression in
vitro.
Beating the Record: 157 Days of Delayed Delivery of The Second Fetus in a Twin Pregnancy
Authors: Climent Lourdes Sala , Agulló D. Borniquel , González Tallada F. Xavier , Sarmiento I. Llordella , Medrano Juárez Javier , Climent Lourdes Sala , Escartín M.J. Pelegay , López N. Redondo
Published: June 2020

Case Report: We present the case of a diamniotic-dichorionic twin pregnancy of 14+4 weeks with obstetric
history of cervical incompetence. The premature delivery of the first twin took place, with unfortunate
outcome. The second twin was left in utero. The management, at first, included combination of expectant
attitude with a close monitoring of maternal constants and analysis, and administration of antibiotics; in a
second step, after discarding intraamniotic infection, a McDonald cerclage was performed with success. At
37 weeks the cerclage was removed and after Oxytocin induction, a healthy baby was born.
Conclusion: Delayed delivery of the second fetus in a twin pregnancy is an effective management choice.
The use of cervical cerclage after the first delivery is associated with a longer inter-delivery interval. The
behaviour in these unusual cases should be assessed individually, due to the scarce literature on the matter
and the lack of unanimous protocols. But, always considering the maternal and fetal status, trying to improve
perinatal results with a strict maternal surveillance to discard the appearance of a possible intraamniotic
infection.
The Role of Rehabilitation in Peripheral Paralysis of the Facial Nerve: A Case Report of a Patient Treated with a Neuro-Cognitive Approach
Authors: Calabrese Mariaconsiglia , Ciriello M. , Calabrese Mariaconsiglia
Published: June 2020

Peripheral paralysis of the facial nerve is a pathology that, although not involves any risks for the patient's
life, significantly affects not only motor, but also communicative, psychological, and social aspects, having
an important impact on the quality of life. The most widely used therapeutic proposals do not always respond
to the need to intervene on all the functional components related to the facial nerve, but to prevent and treat
complications. The neuro-cognitive proposal, although not found in the literature or in the biomedical
databases, takes into account the motor, communicative, verbal and non-verbal functions related to facial
mimic, as well as the cognitive-exploratory function of some districts of the face and intervenes following
the phases of nervous recovery limiting an abnormal reinnervation. The case reported concerns a patient
with a paralysis caused by surgical removal of acoustic neuroma (vestibular schwannoma), with grade III
on the House-Brackmann scale, seems to be an example of how an approach of this type is constructed in
such a way as to follow the various phases of recovery of the peripheral nerve injury, promoting the recovery
of the various functions related to the facial. The patient evaluated with the Sunnybrook Facial Grading
System (SFGS) went from 21/100 to 92/100 and did not develop synkinesias after about 5 months of
treatment. The neuro-cognitive approach would seem to progressively improve the quality of movement.
Moreover, being selective with respect to muscle recruitment and inserted in a functional perspective that
respects recovery times, it would seem to limit the appearance of pathological sequelae such as synkinesias
and spasms.
Manual Cranial Treatment in a Young Woman with Anorexia Nervosa: A Case Report
Authors: Moser Ulrich , Moser Ulrich
Published: June 2020

Background: Anorexia nervosa (AN) is a serious mental disorder affecting mainly young women. Despite
the severity of the disease, the danger of chronification and premature death, and the social burden, the
evidence base for its treatment is weak. In addition to the changed eating behavior, a modified body schema
seems to play a major role in AN.
Case Report: Presented is the course of AN in a now 17-year-old female patient in which a definite
improvement of her symptoms occurred in temporal connection with manual cranial treatment. The manual
approach is based on tonus changes of the deep suboccipital muscles as a monitor to identify relevant
dysfunctions, to ensure the optimal therapy setting and to control the therapy outcome.
Conclusion: AN is an example of a neuropsychiatric disorder whose neurobiological correlates could have
resulted in the increased circumscribed cranial tension in the case presented. The pleasing course may
encourage us to consider manual cranial treatment in similar cases.
Comparison of Three Saliva Collection Methods to Assess Physiological Markers
Authors: Ali Ajmol , Ali Ajmol , Starck Carlene , Dulson Deborah K. , Rutherfurd-Markwick Kay
Published: June 2020

Background: To compare three saliva collection methods for examining salivary biomarkers in males and
females at rest and exercise.
Methods: Whole saliva was collected using drool method (unstimulated, UWS), mastication (stimulated,
SWS) or using cotton-buds placed around the mouth (unstimulated, Bud) from 8males and 12females.
Samples were analysed for flow rate, osmolality, sodium, potassium, chloride, secretory salivary
immunoglobulin A (SIgA), α-amylase activity and cortisol during both rest and exercise in a randomised
crossover design.
Results: SWS and Bud methods were consistently more reliable than UWS, and Bud had the greatest
reliability across all measures. Significant variations between all methods existed for total osmolality,
sodium and SIgA concentrations; between UWS and SWS methods for flow rate and α-amylase activity,
and between UWS and Bud methods for potassium. SWS most consistently replicated UWS patterns of
analyte responses to exercise for both males and females and showed good agreement with UWS for cortisol.
Both SWS and Bud data reflected the inverse α-amylase/cortisol relationship seen in UWS.
Conclusion: SWS was better able to replicate results measured from UWS, between rest and exercise and
between males and females. SWS and Bud methods can be used to inform comparisons between rest and
exercise and males and females
A Redo of Duct-To-Mucosa Pancreaticojejunostomy for Recurrent Acute Pancreatitis Due to Intra-Pancreatic Lithiasis and Anastomotic Stricture: Is This a Reasonable Strategy?
Authors: McCormack Lucas , CM Cobos , F Laxague , McCormack Lucas , Darío Ramallo
Published: June 2020

Few studies have examined the postoperative long-term complications after partial pancreatoduodenectomy
and there are mainly focused in the presence of biliary strictures. The occurrence of intra-pancreatic lithiasis
secondary to the presence of late stenosis of the duct-to-mucosa pancreaticojejunostomy is an extremely
rare condition. We observed that the late occurrence of a pancreaticojejunostomy stricture could be a
potential cause for acute pancreatitis in long-term survivors following partial pancreatoduodenectomy. The
importance of this report is to emphasize that the strategy of a redo of this difficult anastomosis is a very
challenging abdominal operation but provides excellent early and long-term results
Mechanical Properties of Cervical Spinal Cord in Neonatal Piglet: In Vitro
Authors: Singh Anita , Singh Anita , Magee Rachel , Balasubramanian Sriram
Published: June 2020

The response of neonatal spinal cord tissue to tensile loading is not well-studied. In this study, isolated fresh
neonatal cervical spinal cord samples, obtained from twelve 2-4 days old piglets, were tested in uniaxial
tension at a rate of 500 mm/min until failure. Maximum load, maximum stress, percentage strain at
maximum stress and modulus of elasticity were reported to be 14.6±3.4 N, 0.34±0.11 MPa, 29.3±5.4% and
1.52±0.8 MPa, respectively. These data can help understand the biomechanical behavior of the spinal cord
in neonates and can be further used in computational modeling to understand injury mechanisms better and
help develop injury prevention strategies.
Influence of Chitosan or Keratin on Titanium Implant Surface - A Systematic Review
Authors: Love Robert , Ranjit Eliza , Sharma Ajay , Hamlet Stephen , George Roy , Love Robert
Published: June 2020

Purpose: This systematic review was carried out to investigate the effects of keratin and chitosan hydrogel
preparations on dental implant osseointegration.
Materials and Methods: The electronic search was conducted on five databases: Scopus, EBSCOhost
MEDLINE, EBSCOhost Dentistry and Oral Science, PubMed, and Web of Science. Studies that determined
the in vitro or in vivo efficacy of keratin and chitosan hydrogel on osseointegration were included in the
review.
Results: Of the 760 studies initially gathered, nine met the inclusion criteria. These studies demonstrated
that dental implants coated with keratin and chitosan hydrogels resulted in improved biological properties.
It was also concluded that the inclusion of chitosan in keratin hydrogels improves the mechanical strength
and helps increase durability through ameliorating degradation and swelling characters. Both the polymers
increased bone-implant contact and new bone formation in animal models.
Conclusion: This systematic review demonstrates that keratin and chitosan hydrogel, is effective in
initiating osteogenesis, reinforcing the currently available evidence that these polymers could be a substrate
in dental implant treatment.
Determination and choice of optimal cut-off grade value using 3d modeling on the example of domestic bif deposits
Authors: Prokopenko O. S. , Kurylo M. M. , Kulyk S. M.
Published: June 2020

Ukraine is in 10 countries with the largest reserves of iron ores, and the iron ore industry and metallurgical complex are budgetary sectors economically important for the country. For now the mining and metallurgical complex is experiencing not the best of times, and experts say that Ukraine is not using its potential, as it should. One of the main steps in inventory calculation is the determination of boundary value. Boundary value is calculated on the basis of geological, economic, technological and social aspects. Using only geological information, you can calculate the most favorable boundary value using geostatistics.

The main cut-off parameter that determines reserves quality of ferruginous quartzites, which require enrichment by magnetic separation, is iron associated with magnetite Femagn. The paper proposes a tool for choosing the optimal cut-off grade values for evaluating BIF deposits using the example one of the West Azov group deposit. Comparison of cut-off parameters for reserves calculation of iron ores within the Azov Group deposits is carried out.

To find the optimal cut-off grade Femagn using geostatistics and spatial modeling, we analyzed the dynamics of changes in the amount of reserves from changes of cut-off grade Fe. Fluctuations in average Fe grade also were took into account. The paper substantiates the optimal cut-off grade values of Fe associated with magnetite in the range of 12–14 %.

The interval of the largest changes in reserves quantity with an increase is fixed for range of 12–18 %. Beyond this interval there is a minimal fluctuation of ore reserves quantity as a result of cut-off grade’s changes.

In order to find optimal cut-off grade values using geostatistics and spatial modeling, it is necessary to follow the dynamics of reserves’ quantity changes depend on Fe cut-off grade, as well as to take into account average Fe grade fluctuations when changing cut-off grade.
Molybdenum mineralization of Serhiivka Au-Mo deposit (Middle Dnipro, Ukrainian Shield)
Authors: Sukach V. V. , Riazantseva L. O. , Somka V. O. , Bondarenko S. M.
Published: June 2020

The article is devoted to molybdenum mineralization of the Eastern flank of Au-Mo Serhiivka deposit, located in the Middle Dnipro megablock of the Ukrainian Shield (USh). The generalized description of mineralization is performed on such important questions: discovery and exploration history, structure and composition of the host rocks, metamorphic and metasomatic alteration of rocks, structural position and localization conditions of molybdenum mineralization, ore composition, description of major ore minerals, morphology of mineralization and the most widespread views about its genesis. Molybdenum ores were discovered and named East-Serhiivka occurrence for the first time in 1974, before the discovery of gold mineralization, which occurred in 1985.

Serhiivka deposit consists of two Mesoarchaean volcanic-plutonic associations (VPA) of different composition: the early mafic and the late felsic. The Eastern flank of the deposit, where the molybdenum mineralization is concentrated, is a structural knot similar to the lying letter “T”. It is formed by complex joint of the sub-latitudinal Serhiivka and sub-meridional Solone subvolcanic bodies and the East-Serhiivka massif of plagiogranitoids of the late VPA, which intrude basic rocks of early VPA. Molybdenum mineralization is localized in linearly elongated zones with a chaotic network of thin quartz, carbonate-quartz veinlets and poor (2–5 %) sulfide impregnation, including molybdenite. About 20 vein-impregnated ore zones have been recovered with up to 100–150 m thickness and 0,01 to 0,3 %, sometimes more than 1 % average molybdenum grade. The ores are subdivided into two major mineral types: 1) quartz-molybdenite; 2) quartz-sulfide-gold-molybdenite. The main components of ores molybdenite and native gold are associated with pyrite, chalcopyrite, magnetite, occasionally – pyrrhotite, arsenopyrite, scheelite, bismuth telluride, silver and others. Typical non-metallic minerals are quartz, carbonate, feldspar, chlorite, amphibole, biotite, sericite. It is supposed hydrothermal-metamorphogenic genesis of molybdenum (and gold) ores. Molybdenite and gold are rarely detected in the same intersections, which indicates separate genesis of these minerals. According to the accepted classification molybdenum mineralization is systemized as linear stockwork.

Molybdenum ores of Serhiivka deposit are mostly considered as independent, separate from gold mineralization, potentially workable mine. It is the most prospective one in the Middle Dnipro region, USh and Ukraine in general. We suggest a comprehensive approach to studying, resource and reserves evaluation of Serhiivka deposit, taking into account the potential of both molybdenum and gold mineralization, as well as concentrations of rhenium and osmium in molybdenite. Geological exploration on the base of this approach will increase investment prospects of Serhiivka gold-molybdenum deposit.
Circular structures of the Northern Black Sea Region a consequence of a planetary catastrophe
Authors: Klochkov V. M. , Klochkov S. V.
Published: June 2020

The paper formulates a new vision of the reasons for the formation of the modern structural-geological appearance of the Northern Black Sea and the offshore area of the Azov Sea. The catastrophic events in the Northern Black Sea, during the Permian-Triassic period, about 250 million years ago, allegedly occurred. Giant asteroid exploded (or just collapsed) when it entered the dense layers of the atmosphere, and its multifarious debris formed numerous circular structures on the Northern Black Sea during the fall. It has suggested that this space catastrophe is the forerunner of the famous Permian extinction of the terrestrial biota.

 Graphically and descriptively, it has been proved that approximately along the Bataisk-Krasnoperekopsk-Izmail line, according to the RSD, 3 large circular structures and up to 20 small ones are decoded. It is proved – the line corresponds to the Northern suture zone, which separates the East-European platform from the Scythian epiorogenic zone. The suture area has been active for approximately 250 million years.

It has been theoretically proved that it is the invasive effect of the cosmic body that is the root cause of the fault zone, which in Cimmeria evolved into the Northern suture zone.

Using modern RSD made it possible to identify large circular structures of the Northern Black Sea Region. These are Azov, Bataisk and Kalamitska.

Major research interest in the segments of the Azov astrobleme in the context of the oil and gas exploration work is determined. It is proved by retrospective geological information that the identifying structures have a significant depth of occurrence and here the earth’s crust should be saturated with a significant number of supply channels (decompression zones) favorable for hydrocarbon migration.
El acuerdo de Paz de El Salvador
Authors: Cardenal Rodolfo
Published: June 2020

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La XXXVI Semana Social: una oportunidad perdida
Authors: Rul-lán Buades Gaspar
Published: June 2020

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"Fundamentos de Bioética" (Recensión)
Authors: Higuera Gonzalo
Published: June 2020

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农村水利工程渗漏的原因及养护管理措施分析
Authors: 裴 利计
Published: June 2020

近年来经济的快速发展,基础设施建设愈发完善,水利工程作为促进农业发展的重要手段,在新农村建设中发挥了重要作用。受当地地质条件及环境,设计,施工等的各方面的影响,农村水利工程易出现渗漏问题,若处理不当将影响工程的质量,及正常的灌溉与排水等功能。文章针对水利工程的渗漏原因进行分析,基于原因提出解决方法、养护管理的相关措施,提高工程质量,减少安全隐患,更好的发挥水利工程的经济效益。
水利水电工程施工质量与安全管理探究
Authors: 孙 广龙
Published: June 2020

现如今,我国愈发注重水利水电工程建设,同时也对其质量与安全提出了更高要求。这就需要水利水电工程建设工作人员在强化水利水电工程深入发展同时,也要对质量安全管理加以关注。立足于水利水电施工建设中存在的不足,进而采取有效地解决措施,加以纠正,才能使我国水利水电工程施工质量得以提升,提高安全管理水平,促进水利水电工程建设的良性发展。
水利水电工程施工项目管理问题的探讨
Authors: 余 翔 , 袁 丹华 , 林 海燕
Published: June 2020

通常水利水电工程施工较为复杂,并且水利水电工程施工所涉及到的参建单位与范围等都具有不确定的因素,使得水利水电工程施工项目管理存在诸多问题,基于此,本文阐述了水利水电工程施工项目管理的主要特征,对水利水电工程施工项目管理存在的主要问题及其对策进行了探讨分析。
加强基层水利服务机构能力建设促进农村水利持续发展
Authors: 莫合买提 阿达来提 •
Published: June 2020

新农村建设在时代快速发展的背景下逐渐进入了正规,人们的生活质量以及生活水平得到了明显的提升,为满足群众的需求,基层水利服务机构也快速发展起来。鉴于此,本文就加强基层水利服务机构能力建设促进农村水利持续发展展开探讨,以期为相关工作起到参考作用。
水轮发电机组调速系统的串级鲁棒控制研究
Authors: 易 晓东
Published: June 2020

在水轮发电机组调速系统中,由于水压力的波动时间以及水启动时间这些系统参数具有一定的不确定性,对调速系统模型有一定程度的影响。为了改良调速系统模型,因此在设计时采用了自控领域鲁棒控制的两种方法来对其进行优化改进。本文在设计调速系统时,设计了两级系统结构,并且相应的设计了两个鲁棒控制器；将伺服电机作为系统的第一级,而在第一级系统中,结合混合灵敏方法设计了第一级的鲁棒控制器；而第二级系统在第一级系统的基础之上,还添加了发电机以及水轮机模型,并且结合μ综合的设计方法设计了第二级的鲁棒控制器。除此之外,本文也对设计的两级控制器的控制效果和抗干扰能力进行了测试验证,测试结果发现控制器不仅能很好的控制水轮机的转动速度,还具有相对不错的鲁棒性,并且在性能上明显优于PID控制系统以及PI控制系统。
浅谈新疆农村小型水利工程“五个一”综合管理
Authors: 阿不利孜 木巴热克 •
Published: June 2020

农村小型水利作为农村基础设施中的基础,其直接关系到农村经济的发展。新疆伊犁区作为水资源短缺的典型区域,农村小型水利工程管理的有效性将直接影响该区域水资源的可持续利用乃至经济发展和社会安定。基于此,本研究在概述农村小型水利工程管理、“五个一”综合管理模式理论基础上,结合伊犁区农村小型水利工程建设现状,总结了工程管理中存在的问题,并对这一综合管理的应用进行探究,旨在为工程管理水平的提升提供借鉴。
农村饮水安全工程规划设计中常见问题及解决思路
Authors: 陈 夫超
Published: June 2020

在现代化农村建设过程中,农村饮水安全是农村经济发展的关键问题,相关部门必须确保农民群众饮水的安全性,为民生工程项目建设提供支持。为了确保农村饮水的安全性,相关部门必须做好工程规划设计工作,为农民群众的生命健康提供保障,为现代化建设的进一步发展提供支持。但是,我国很多农村饮水安全工程建设中仍存在一系列问题,这就需要强化设计规划工作,文章主要分析了农村饮水安全工程规划设计中常见问题及解决思路。
水利水电工程造价影响因素分析及控制造价的措施
Authors: 李 远洋
Published: June 2020

企业要想实现长远发展目标,必须加大对工程造价控制的重视度,节约投资成本,拓展经济效益的增长空间。但水利水电工程造价的影响因素较多,而且这些影响因素制约了企业的良好发展。为此,本文围绕水利水电工程造价影响因素与造价控制手段展开系统探究。
浅谈农村电网用电信息采集系统
Authors: 陆 悦
Published: June 2020

农村电网与生俱来具有分布广、负荷分散且明显随季节波动的特点。因此,供电公司如何进行用电信息采集系统建设工作,适应农村用电客户的需要,推进“城乡供电服务一体化”,已经成为一个社会各界共同关注的课题。鉴于此,文章就农村电网用电信息采集系统进行了分析。
节水灌溉技术在农田水利工程中的应用
Authors: 连 峻
Published: June 2020

节水灌溉技术在提升水资源应用效率、促进我国农业健康稳定发展方面发挥着关键性的作用,尤其在水资源短缺问题日渐严峻的现代社会,高效节水灌溉技术的应用至关重要,它不仅有助于农田水利工程经济效益的稳步提升,同时也促进了农业的协调稳步发展,现实意义重大。本文主要对高效节水灌溉技术在农田水利工程中的应用进行了研究。
水利水电工程建筑的施工技术及管理分析
Authors: 黄 颍湫
Published: June 2020

随着我国社会经济的不断进步和发展,我国的水利水电工程建设取得了很大的成就。提高施工的技术以及加强施工的管理可以更好地建设现代水利水电工程,并且施工的效果不仅关乎人们的需求还会直接关系到工程的经济效益。本文将从水利水电建筑工程技术管理以及要点等方面,针对如何做好水利水电建筑工程技术工作进行具体阐述。
水利水电工程施工中的质量管理探析
Authors: 李 露露
Published: June 2020

水利水电工程是社会经济发展的基础性工作,在实践过程中扮演着非常重要的作用。为综合发挥水利水电工程的整体价值以及社会作用,在水利水电工程的建设过程中,应该突出质量管理,全面强化质量管控。依托于科学精细、标准全面的质量管理措施,切实提升水利水电工程的施工质量以及施工水平,整体优化水利水电工程的社会经济效益。
生态水利设计理念在城市河道治理工程中的应用
Authors: 吴 蓉珍
Published: June 2020

随着城市化进程的日益加快以及人们生态意识的不断提升,越来越多的现代理念被应用到城市河道治理工程当中,其中就包括生态水利设计理念。当前对于这一理念的相关应用研究并不是特别多,基于此,本文就生态水利设计理念在城市河道治理工程中的应用进行了探究。
浅析水利水电工程建设对生态环境的影响
Authors: 向 月群
Published: June 2020

水是生命之源,是人们赖以为生的基本条件,水资源的开发对提升我国经济效益,提升人们的生活品质有着重要的作用。水利水电工程建设不仅在于保护生态环境,更为人们提供重要的生活和生产的能源支持。本文针对水利工程建设对于生态环境的影响以及对策分析。
供水工程隧洞施工合同管理途径
Authors: 李 逢祥
Published: June 2020

本文从供水工程隧洞施工合同管理内容、范围,具体的管理方法以及是索赔管理等方面进行了具体的分析,希望相关单位及工作人员能够提升合同管理意识,为相关研究提供微薄的帮助。
关于大中型泵站电气设备的安全运行与维护的思考
Authors: 张 林
Published: June 2020

科学技术的完善,提高了对技术设备的要求,大中型泵站也不例外。大中型泵站为我国行业提供了新鲜血液,但在发展的过程中也出现了明显的问题。电气设备维护是泵站运营的重难点问题,工作难度较大,覆盖范围较广,若泵站电气设备安全维护不到位,则会阻碍泵站的稳定运行。
水电站集控运行安全风险及应对措施
Authors: 李 阳
Published: June 2020

加强水电站集控运行安全,能有效提高水电站集控运行的水平,从而有效降低风险发生的可能性,本文就水电站集控运行安全风险进行分析,并提出相应的应对措施,为加强水电站集控运行安全工作带来一些借鉴。
灌区干渠节水改造施工质量管理探讨
Authors: 杨 明霞
Published: June 2020

随着我国经济的发展,我国对于水利建设的要求越来越高,为了更好的促进农业发展和生态建设,要对原有的灌区进行改造,对于灌区而言主要是由水库和渠道组成,可以保证灌区的耕作物有充足的水源,为了进一步保证灌区内的耕作物更好的生长,要不断完善灌区内的水库设施和干渠,要对灌区干渠进行节水改造,这样可以避免浇灌过程中水资源的浪费,使得灌区内的农作物能得到充足的水分,在灌区干渠节水改造施工过程中,要重视其施工质量管理,合理应用节水施工技术,保证干渠的节水性,进一步促进我国农业的发展。基于此,本文简要探讨了灌区干渠节水改造施工质量管理控制措施。
水土保持的必要性与方法
Authors: 吴 国新
Published: June 2020

近年来,我国经济发展迅速,工业化的崛起使得我国由传统的农业大国向发达的工业国家转型,在发展的过程中,越来越多的林地和农耕地用于经济建设,这就使得我国的生态环境遭到破坏,水土流失的情况比较严重。为了更好的促进我国的经济发展,一定要统筹做好生态保护和经济发展,重视水土保持工作,加强生态建设,要颁布相关法规保护农耕地、林地及水利方面,这样才能避免水土流失越来越恶化,有效的改善我国的生态环境。基于此,本文简要探讨了水土保持的必要性与有效措施。
高效节水灌溉技术在农田水利工程中的应用
Authors: 刘 先龙
Published: June 2020

我国水资源并不丰富,并且还存在南北不均的问题,所以应该珍稀水资源。在农业灌溉中应该推崇节水技术,提高农田灌溉水资源的利用率。我国目前存在多种高效节水灌溉技术,包括微灌灌溉技术、喷灌灌溉技术等,但是该技术在应用过程中并未取得良好的效果。节水灌溉技术应该充分结合其地域特征进行必要的设计修改,使其可以符合当地的地域条件。本文通过我国农田水利工程的实施现状分析其高效节水灌溉的措施。
水利水电工程建设中的大坝除险加固设计
Authors: 郑 乐
Published: June 2020

大坝除险加固设计通常是为了保证洪水来临时,可以发挥其有效的抗灾功能,同时可以给周边居民的养殖与灌溉等提供需要,并且为大坝周边居民的生命财产安全提供良好保障,因此为了保障大坝的安全运行,本文阐述了水利水电工程建设中的大坝除险加固设计要求及其原则,对水利水电工程建设中的大坝除险加固设计进行了探讨分析。
研究提升水电厂自动化能力的技术创新
Authors: 李 新怀
Published: June 2020

现代社会各行各业由于科技与经济的进步均获得了较大的发展,其中,水电厂中自动化技术的发展对水电厂的发展有着非常重要的意义。水电使用与人们的生活联系紧密,其自动化发展为水电工程建设带来更多的机遇与挑战。本文对水电厂中自动化技术的应用特点及作用结构进行了分析,并提出了部分现目前水电厂自动化发展中存在的问题,同时还对水电厂自动化技术创新发展应用进行了分析与总结。
PENGARUH HARGA TERHADAP KEPUTUSAN PEMBELIAN KOPI EXELCA SEDUH DI WARUNG POJOK WONOSALAM JOMBANG
Authors: Wahyuni Dwi
Published: June 2020

Penelitian ini bertujuan untuk mengetahui dan menjelaskan pengaruh harga terhadap keputusan pembelian kopi exelca seduh di warung pojok Wonosalam. Penelitian ini merupakan jenis penelitian kuantitatif. Adapun populasi dalam penelitian ini yaitu semua pembeli kopi exelca seduh di warung pojok Wonosalam, sedangkan sampel yang digunakan sebanyak 67 pembeli untuk menjadi responden penelitian. Teknik analisis yang digunakan dalam penelitian ini menggunakan analisis regresi linier sederhana dengan uji t. Hasil penelitian menunjukkan ada pengaruh positif dan signifikan harga terhadap keputusan pembelian kopi exelca seduh dengan pengaruh sebesar 0,188 atau 18,8% dan signifikan pada variabel harga sebesar 0,000 kurang dari 0,05. Sehingga Ho ditolak dan Ha diterima yang artinya variabel bebas terbukti mempunyai pengaruh yang signifikan terhadap keputusan pembelian.
PENGARUH PRODUK DOMESTIK REGIONAL BRUTO (PDRB), JUMLAH PELANGGAN, DAYA YANG DIKONSUMSI TERHADAP PAJAK PENERANGAN JALAN DI KABUPATEN LUMAJANG
Authors: Murdiansyah Isnan , Wahyuni Nanik , Lestari Yona Octiani
Published: June 2020

Pemerintah daerah diperkenankan untuk melakukan pemungutan pajak daerah sesuai dengan Undang-Undang No.28 Tahun 2009. Pemungutan pajak daerah di suatu Daerah disesuaikan dengan potensi dan kebijakan daerah yang ditetapkan dengan Peraturan Daerah (Perda). Target penerimaan pajak penerangan jalan di Kabupaten Lumajang yang ditetapkan setiap tahun selalu ditingkatkan oleh Pemerintah Kabupaten Lumajang. Sedangkan jika dilihat dari pencapaiannya selalu melebihi target yang ditetapkan akan tetapi hal itu tidak selaras dengan pertumbuhannya. Hal ini mengindikasikan realisasi penerimaan pajak penerangan jalan di Kabupaten Lumajang belum sesuai dengan potensi yang ada. Tujuan penelitian ini adalah untuk mengetahui pengaruh domestik regional bruto (PDRB), Jumlah pelanggan dan daya yang dikonsumsi terhadap pajak penerangan jalan di Kabupaten Lumajang. Penelitian ini menggunakan data sekunder periode 2005-2014. Metode analisis yang digunakan dalam penelitian ini adalah metod deskriptif kuantitatif dengan analisis regresi pada data yang sudah diinterpolasi. Penelitian ini menghasilkan temuan bahwa PDRB, jumlah pelanggan dan daya yang dikonsumsi dapat mempengaruhi pajak penerangan jalan di Kabupaten Lumajang dan variabel independen tersebut berpengaruh positif dan signifikan secara simultan terhadap penerimaan pajak penerangan jalan di Kabupaten Lumajang. Dan hasil perhitungan kontribusi pajak penerangan jalan terhadap PAD menunjukkan hasil yang bagus.
MODERNISM IN “MABEL” AND “THE ROCKING-HORSE WINNER”
Authors: Harahap Aris Masruri
Published: June 2020

Modernism in writing had influences or impacts from the Industrial Revolution that took place before and after the turn of the 20th century. Unsurprisingly, it affected many changes in human’s thought. In this article, I discussed influences of the changes that are represented in two short stories titled “Mabel” by W.S. Maugham and “The Rocking-Horse Winner” by D.H. Lawrence.
TEACHING VOCABULARY TO YOUNG LEARNER USING VIDEO ON YOUTUBE AT ENGLISH COURSE
Authors: Hariyono Tira Chairiah
Published: June 2020

Vocabulary is one of the important elements of the English language. There are many media which can be used in teaching vocabulary to young learners. In this research, the researcher used video on YouTube to teach vocabulary. The research focuses on how students’ engagement during the implementation of video on YouTube in teaching vocabulary at an English course. In this research, the researcher used descriptive–qualitative research, and observation and documentation were used for collecting the data. This research was conducted at an English course in Bogor, in which the participants are seven young learners at grade two. The findings of this research were classified into two themes; students’ response to the classroom activities and the teacher instruction, and student’s engagement to the use of video on YouTube. It is revealed that most young learners at an English course were engaged during the implementation of the video on YouTube in teaching vocabulary. They also gave positive responses to the learning activity and preferred learning English vocabulary by using video on YouTube.
EXAMINING THE ISSUE OF ABOLISHING ENGLISH TUITION IN PRIMARY SCHOOL IN INDONESIA
Authors: Azmy Khairul
Published: June 2020

This paper examines the reasons behind the philosophy of the Indonesian government’s decision on abolishing English tuition in primary school. The Indonesian government has recently omitted English as compulsory tuition since English has been excluded in the curriculum at the primary level. The findings show that people have misinterpreted about whether English at the primary level is a compulsory, local-content or extracurricular tuition. In addition, it is found that teaching English at a young age is not practically efficient in Indonesia due to lack competence of teachers, unrelated syllabus and uninteresting teaching methods. Furthermore, the misconception of younger foreign language learners and cultural discrepancy are the other key findings in the issue provided. Ultimately, the implications of this article have given new insights on the issue of abolishing English tuition, whether it is effective or significant for primary students in Indonesia at this moment and condition.
Justification of the priority controlled sanitary-microbiological parameters to ensure the safety of hospital environment, medical organizations stationary type, regardless of their functional purpose
Authors: Yudin S. M. , Rusakov N. B. , Zagainova Anzhelika V. , Gritsyuk O. V. , Kurbatova I. V. , Fedets Z. E. , Novozhilov K. A. , Abramov I. A. , Rakova V. M. , Doskina T. V. , Sukhina M. A.
Published: June 2020

Introduction. The work is devoted to evaluating the results of our own research of sanitary-microbiological monitoring of environmental objects in diversified treatment-and-prophylactic institutions of stationary type and of the analysis both of domestic and foreign data in order justify of the list of priority controlled sanitary-microbiological indices of air and surfaces to ensure the safety of hospital environment, medical organizations stationary type, regardless of their functional purpose. Material and methods. The survey was conducted in various premises in the medical-prophylactic institutions of stationary type for two years. Studies included determination of microbial contamination of the air environment, working surfaces, hands of personnel with the detection of bacteriological, virological, and mycological parameters, followed by macroscopic and microscopic identification of microorganisms and identification using automated systems with the method of time-of-flight matrix-assisted laser mass spectrometry platform MALDI-TOF, based on the study of the mass spectra of ribosomal proteins in the range of 1000-10000 Daltons and bioinformatic comparison of the obtained spectrum with database reference spectra and PCR. Results. As a result, the research of surface washings in the premises of a multidisciplinary clinic revealed microbial contamination with conditionally pathogenic gram-positive cocci, including S.aureus, gram-positive and gram-negative bacteria posing a serious epidemiological danger to patients in these wards regardless of the MOST profile and requires mandatory monitoring taking into account of the used disinfectants. Conclusion. Our own research and analysis of domestic and foreign literature showed that it is not enough to monitor the air in the MOST premises only in terms of total microbiological contamination. In the operating, procedural and dressing blocks, as well as in the wards, physiotherapeutic, diagnostic, laboratory rooms and auxiliary units, it is also necessary to take into account other sanitary and microbiological indices: total microbes count, gram-positive rods and cocci, including S.aureus, fungi, adeno-, entero-, astroviruses, coliphages.
István Sandor, Fiduciary Property Management and the Trust. Historical and Comparative Law Analysis (Budapest: HVG-ORAC, 2015)
Authors: Hamza Gábor
Published: June 2020

Book review of: István Sándor, Fiduciary Property Management and the Trust. Historical and Comparative Law Analysis (Budapest: HVG-ORAC Publishing Ltd., 2015, 465 p.)
Uttam Kumar Sinha & Jo Inge Bekkevold (eds.), Arctic: Commerce, Governance and Policy (New York: Routledge, 2015)
Authors: Exner-Pirot Heather
Published: June 2020

Book review of: Uttam Kumar Sinha & Jo Inge Bekkevold (eds.), Arctic: Commerce, Governance and Policy (New York: Routledge, 2015)
Hydrozoan colonization and succession in the tidal and subtidal zones in Surtsey during the period 1967 to 1984
Authors: Lundsteen Steffen , Hauksson Erlingur , Gunnarsson Karl
Published: June 2020

This article reports on results of investigations of hydrozoans collected in Surtsey, Iceland in the period
1967 – 1984. Samples were collected in the intertidal zone and by divers in the subtidal zone down to 40
m. A list and illustrations of hydrozoan species found in the intertidal and subtidal rocky bottom in Surtsey
are presented. Species numbers increased steadily during the study period and in 1984 a total of 37 species
were recorded in Surtsey making hydrozoans one of the most diverse marine invertebrate groups in Surtsey.
Among hydrozoans found during the study are 8 species not previously recorded in Iceland. Apart from
dispersal by planktonic medusa, rafting of polyps on floating objects drifting to Surtsey is thought to be
important for colonisation of hydrozoan fauna in Surtsey. At the end of the investigations period, 20 years
after formation of rocky shores on the island, number of species seemed to be continually increasing
Observations on the structure of Surtsey
Authors: Moore James C. , Jackson Marie D.
Published: June 2020

Comparison of investigations of the 1979 and 2017 cored boreholes coupled with continued observations
of the dynamic surface of Surtsey has modified our concepts of the subsurface structure of the volcano.
A geometrical analysis of the 2017 vertical and inclined cores indicates that near-surface layering dips
westerly, indicating that the boreholes are located inside the Surtur crater. In subaerial deposits, as well as in
deep deposits below sea level and below the pre-Surtsey seafloor, there are zones of porous tuff that contain
abundant pyroclasts with narrow rims of fine ash. These features, typical of near-surface deposits, could
have been carried down the vent by downslumping during fluctuating explosive activity. They support the
hypothesis that a broad diatreme underlies the Surtur vent. No major intrusions were encountered in the
2017 drilling except for coherent basalt in deep sub-seafloor deposits below the center of Surtur crater.
The 2017 borehole temperature measurements indicate that the peak temperature in the vertical boreholes
was 124 °C at 105 meters below the surface (m.b.s.) and that in the inclined hole it was 127 °C at 115
m.b.s. immediately after drilling. These peak temperatures are 72 meters apart horizontally yet closely
resemble each other in shape and magnitude, suggesting a broad heat source. In addition, measurements in
the inclined hole from 200 to 290 m.b.s. indicate a temperature of 60±2 °C. This is apparently residual heat
from the volcanic action that created the diatreme. These facts cast doubt on the previous concept that the
heat anomaly in the 1979 borehole was due to a nearby intrusion. Instead they suggest that heat would have
been conducted down from the 85-meter-thick hot lava shield within the Surtur crater into a warm diatreme
substrate containing original volcanic heat. As the conducted heat moved down into the water-saturated
substrate it would have elevated the temperature above the boiling point curve, baked out water, and created
a vapor-dominated system below sea level. Eventually loss of heat by boiling and rise of steam caused the
vapor-dominated system to retreat upward. The resulting steam rose and warmed the tephra adjacent to the
lava shields where it produced broad areas of palagonitized tuff.
Availability of plant nutrients and pollutants in the young soils of Surtsey compared to the older Heimaey and Elliðaey volcanic islands
Authors: Sigurdsson Bjarni D. , Leblans Niki I. W.
Published: June 2020

Surtsey and the older islands in the Vestmannaeyjar archipelago offer a unique possibility to study how
sub-Arctic ecosystems develop from unvegetated mineral substrate that lacks soil cover to grasslands with
thick Brown Andosol soils. The present study was carried out on Surtsey, Heimaey and Elliðaey in 2013
and involved an incubation of resin membranes in the 0-10 cm topsoil layer in different ecosystems, which
were either inside or outside seabird colonies. We compared the effects of seabird presence on soil nutrient
availability as well as the importance of time for soil development (at least ca.1600 years vs. 50 years).
Further we looked for build-up of Cd and Pb within the seabird colonies. Seabird presence enhanced the
availability of most nutrients (N, P, K, Mg, Ca, S, Fe, Mn and Zn) except B and Cu, irrespective of the
age of the islands. Soil age was also a significant factor for nutrient availability for all macro- and micronutrients except B. Nutrient ratios indicated that N was the most limiting nutrient in all ecosystems, except
in the thicker tephra soils on Surtsey where low P availability may lead to co-limitation. The role of P in
ecosystem function on Surtesy warrants a futher study. No accumulation of Cd and Pb was found within
the seabird colonies.
Genetic parameters estimate and characters analysis in phenotypic phase of soybean during two evaluation periods
Authors: Hanyu Joe , Costa Silvana , Cecon Paulo , Matsuo Éder
Published: June 2020

Recent studies have shown the need to identify new potential additional descriptors for the soybean culture to contribute to cultivars differentiation. Thus, the objective of this study was to estimate generic parameters and analyze characters in the soybean plants in phenotypical phase, during two evaluation periods. The study analyzed 28 genotypes under greenhouse conditions, during two evaluation periods (October and December, 2017), in two stages of development (V2 and V3), regarding hypocotyl and epicotyl length and plant height. Experimental units (an average of two plants) were displayed in randomized blocks with four replicates. An individual and joint analysis of variance were conducted, and coefficients of experimental variation and genotypic determination were estimated for each character analyzed as well as the ratio between the experimental and genetic variation coefficients. Next, mean tests and the analysis of the phenotypic and genotypic correlation were carried out. Results showed that the genotypes analyzed differed in regard to hypocotyl and epicotyl length and plant height, at the V2 and V3 stages of development. In addition, the estimated magnitude of the genetic parameters and genotypic correlations showed genetic influence on the phenotypic expression of the hypocotyl and epicotyl length and plant height at the V2 and V3 stages of development.
Mediating Role of Empathy in the Relationship between Emotional Intelligence and Thinking Styles
Authors: KORKMAN Hamdi , TEKEL Esra
Published: June 2020

The aim of the study is to examine the mediating role of empathy in the relationship between rational and experiential thinking styles and was designed in a correlational design. The sample of the study consists of 593 university students who were determined by simple random sampling method. Emotional Intelligence Questionnaire–Short Form, Empathy Quotient Scale, and Rational-Experiential Thinking Styles Scale were used for data collection. Bootstrapping method and Pearson product moments analysis were used to analyze the mediating role of empathy. Results indicated that there are significant relationships between the variables. In addition, empathy is a full mediation in the relationship between emotional intelligence and experiential thinking style and empathy is a partial mediation in the relationship between emotional intelligence and rational thinking style.
Views of Prospective Teachers on Learning Responsibility
Authors: Baltaoğlu Meltem Gökdağ , Meral GÜVEN
Published: June 2020

This study aims to reveal the views of prospective teachers, who study at the faculty of education, on learning responsibility. This study is performed on the basis of the basic qualitative research method. The study group of the research is composed of a total of 48 prospective teachers whose views are received on a voluntary basis and who are enrolled in the Psychological Counseling and Guidance Department of the faculty. 29 of prospective teachers participating in the research are females and 19 of them are males. In the research, data are collected through an open-ended survey design to identify the views of prospective teachers on learning responsibility. Research data are analyzed through content analysis technique. Views of prospective teachers are grouped under certain categories by two researchers upon reading each answer for open-ended questions. The frequency of views/responses expressed by prospective teachers for each category is specifically demonstrated. At the end of the study, it is concluded that, firstly, definitions of prospective teachers for learning responsibility are on themes of study skills, learner’s independence, responsibility-awareness; secondly, their views on how learning responsibility is supposed to be achieved are on themes of the association of the learner with himself/herself, with the family and with the teacher, and lastly, their views on duties of teachers are on themes of sensational skills, method & technique, raising awareness about learning responsibility and academic skills.
Сигнальний шлях Wnt за пухлинного росту, можливості фармакологічної корекції
Authors: Шарикіна Н. І. , Пуськов О. М. , Хавич О. О. , Радівоєвич А. Г. , Мунько М. А. , Бухтіарова Т. А.
Published: June 2020

У статті наведено сучасні дані щодо клітинного сигнального шляху Wnt, який відіграє значну роль у регуляції гомеостазу та зумовлює низку злоякісних новоутворень за патологічної експресії його ланок. Зазначено основні, у тому числі патологічні, ланки передачі клітинних сигналів Wnt як мішені для пошуку таргетних протипухлинних засобів. Означено 3 етапи пошуку та вивчення таргетних препаратів щодо Wnt і стан їхнього розвитку в світі: – вивчення відносно шляху Wnt затверджених для клінічного використання за іншими показаннями препаратів (суліндак, целекоксиб, вітаміни А та Д, пірвіній, кверцетін, куркумін, ресвератрол та ін.); – доклінічні дослідження нових фізіологічно активних речовин з певною активністю щодо Wnt сигналінгу (XAV-939, GW55, G007-LK, G244-LM); 

– клінічні випробування сполук, що виявили здатність впливати на Wnt сигналінг (LGK-974 (інгібітор поркупіну), ICG001, PRI-724, антитіла, що нейтралізують Wnt-ліганди та рецептори). Загальна думка онкофармакологів і клініцистів свідчить про перспективу одержання препаратів, здатних впливати на патологічну експресію шляху Wnt з більш високою активністю, ніж у класичних цитостатичних засобів.