bluuebunny/crossref_metadata_2025 huggingface dataset:
Sudden Cardiac Arrest during Participation in Competitive Sports - systematic review
Authors: Rymaszewska Katarzyna , Gajdzińska Natalia , Puchała Justyna , Starzomska Dominika , Salwa Adam , Rutkowski Wojciech , Sztuba Karolina , Rostkowska Weronika , Rzepka Maciej , Basiura Karolina
Published: August 2024

Introduction: Sudden cardiac arrest during sporting events always arouses strong emotions.No one expects that sudden cardiac arrest could occur in a young, athletic person.There are about 90 cases of sudden cardiac arrest in Poland every day. It may seem that mainly elderly, sick people are at risk of sudden cardiac arrest. Theoretically, this problem should not concern young, athletic people who take part in sports competitions. Numerous screening tests and check-ups should eliminate the risk of sudden cardiac arrest in athletes, but the reality is different. The aim of the following paper is to review the literature on cardiac arrests in athletes during sporting eventsMaterial and methods: We have gathered the available materials and scientific reports, analyzing and summarizing them in a single study.Aim of study: Study objective: The aim of our study was to summarize the latest knowledge on sudden cardiac arrest in athletes during sports events.Conclusions: Screening tests reduce the incidence of sudden cardiac arrest in athletes. The most common cause is previously unrecognized heart defects - hypertrophic cardiomyopathy. Football players are most at risk of sudden cardiac arrest. The most important factor influencing survival in sudden cardiac arrest is time
Phenylketonuria: A Comprehensive Review of Pathophysiology, Diagnosis, and Management Strategies
Authors: Konopka Agata , Szczepaniak Zuzanna , Wdowiak Natalia , Ziółkowska Dominika , Adamska Kinga , Lissak Karina
Published: August 2024

Introduction: Phenylketonuria (PKU) is a genetically determined congenital metabolic disorder characterized by the body's inability to properly metabolize the amino acid phenylalanine, which is ingested through food. This deficiency leads to the accumulation of phenylalanine in the blood. If untreated, this can result in neurological damage and cognitive impairments. Despite significant progress in understanding the disease, along with advancements in diagnostic methods, the fundamental approach to managing PKU has remained consistent: early detection and adherence to a diet low in phenylalanine are essential to preventing the adverse effects of the disorder.
Purpose of the work: The aim of the study is to analyze and present the current knowledge about phenylketonuria and the quality of life of patients suffering from this disease, as well as methods of its detection.
Materials and methods: An analysis of research papers available on PubMed and Google Scholar was undertaken using the following keywords: phenylketonuria; PKU diagnosis; phenylketonuria newborn screening; genetic testing for PKU; Quality of Life in PKU patients.
Results: There are various diagnostic methods used in newborn screening and to confirm diagnosis. Regardless of the method, early diagnosis and the introduction of an appropriate diet are crucial. Adherence to dietary restrictions and monitoring phenylalanine levels, along with managing the effects of elevated levels in the body, may negatively impact the quality of life for individuals affected by PKU.
Vitamin B12 - is it worth supplementing?
Authors: Wojaczek Marta , Polańska Katarzyna , Kahan Weronika , Szafrańska Weronika , Poborowska Dominika , Bąk Emilia , Fordymacki Jacek , Najjar Oliwia , Gańko Tomasz
Published: August 2024

Abstract
Introduction
Cobalamin is a vitamin that plays an important role in many processes occurring in our body. It affects, among others, the functioning of the hematopoietic, nervous, and digestive systems and the functioning of the psyche. Its deficiency can be encountered in everyday clinical practice. Many scientific studies have been conducted on it, focusing on the causes and effects of its deficiency.
 
Purpose
 
This work aims to identify groups of patients whose risk of vitamin B12 deficiency is higher than in the general population. This will help draw attention to these selected groups of patients, so that in clinical practice, vitamin B12 supplementation may be considered before symptoms of its deficiency occur.
Brief description of the state of knowledge
The most common cause of vitamin B12 deficiency is Addison-Biermer's disease caused by the presence of autoantibodies against Castle's intrinsic factor. However, there are more factors that indirectly affect the level of cobalamin in the body.
Material and methods
In this work, we analyzed the following conditions and diseases that are correlated with vitamin B12 deficiency: medications taken, gastrointestinal diseases, conditions after bariatric surgery, pregnancy, vegan diet, old age, and alcohol.
Discussion:
After analyzing selected issues, we conclude that the risk of vitamin B12 deficiency varies, in some cases, it is correlated with advanced disease, and in others, it is independent of it. Additionally, it should be taken into account that although the pathomechanism leading to vitamin B12 deficiency is known in the above-mentioned conditions, the real risk of its deficiency may be so low that its clinical significance will be low.
Use of VKAs and NOACs as stroke prophylaxis in patients with atrial fibrillation - a review of the literature
Authors: Jama Grzegorz , Kmiotek Weronika , Różańska-Smuszkiewicz Gabriela , Smuszkiewicz-Różański Paweł , Oronowicz Radosław , Wesołek-Bielaska Ewelina , Kuzio Agnieszka , Cieplińska Aleksandra , Ziojła-Lisowska Kinga , Piasecka Zuzanna
Published: August 2024

Introduction and Purpose: Stroke is a common complication of one of the most common cardiac arrhythmias, atrial fibrillation. The aim of this study is to provide key information about these diseases and to compare the drugs used to prevent stroke.
Materials and methods: A literature search was conducted using the medical databases PubMed and Google Scholar. Articles were retrieved in English, employing the key words: “VKA “, „NOAC”, „atrial fibrillation”, „anticoagulants“ and „stroke” appropriate configurations.
Conclusions: According to the recommendations and available medical literature, the use of NOACs is usually the most appropriate choice for stroke prevention in patients with atrial fibrillation. However there are also clinical situations, in which the use of VKAs would be more appropriate.
Diagnosis and treatment of subacute thyroiditis - a review of the literature
Authors: Cąkała Marlena , Kozioł Magdalena , Podgórniak Kamila , Zajkowska Aleksandra , Skotnicka Joanna , Witkowska Maria , Szymchel Michał , Grzegorzak Filip
Published: August 2024

Introduction: 
Subacute thyroiditis (SAT) is an inflammatory condition of the thyroid with characteristic presentations and clinical courses. The pathogenesis and determinants of the clinical course were unclear for many decades. The last few years have brought many clinically significant new data on the epidemiology, pathogenesis and management of subacute thyroiditis. The diagnosis is based on clinical presentation, laboratory tests (ESR, TSH, antithyroid antibodies), imaging tests (thyroid ultrasound, thyroid scintigraphy) and cytological tests. Taking into account all the new aspects of subacute thyroiditis pathogenesis and of its clinical course, the new - modified - criteria of subacute thyroiditis diagnosis have been proposed.
Aim of the study:
In this review, we provide a comprehensive overview of the current knowledge regarding subacute thyroiditis, including its epidemiology, pathophysiology, diagnostic methods, and the existing treatment options.
Brief description of the state of knowledge:
Many cases of subacute thyroiditis follow an upper respiratory viral illness, which is thought to trigger an inflammatory destruction of thyroid follicles. In most cases, the thyroid gland spontaneously resumes normal thyroid hormone production after several months. The most characteristic laboratory finding is a high erythrocyte sedimentation rate (ESR). C-reactive protein and white blood count (WBC) are also elevated in many cases. Anti-thyroid antibodies are believed to be usually normal. The ultrasound (US) pattern of subacute thyroiditis includes hypoechoic and heterogeneous areas with blurred margins, poorly vascularized on color Doppler. Treatment with high-dose acetylsalicylic acid or nonsteroidal anti-inflammatory drugs is directed toward relief of thyroid pain. It has been noticed that patients with a diagnosis of subacute thyroiditis visit more other clinics and receive antibiotics unnecessarily.
Semaglutide versus Tirzepatide - comparison of both drugs in treatment of diabetes type 2 and weight reduction
Authors: Staroń Arkadiusz , Karkos Patrycja , Kuśmierczyk Katarzyna , Gastoł Bartłomiej , Mikołap Karolina , Kras Marta , Jurga Marta
Published: August 2024

In recent years, the popularity of drugs which were firstly introduced as treatment for diabetes type 2 has surged, because of their’s significant effect of managing the body weight especially for patients that suffer for diabetes type 2. Tirzepatide is a dual glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 (GLP-1) receptor agonist. Semaglutide is a glucagon-like-peptide 1 receptor agonist. The aim of our study is to present reliable and up-to-date knowledge of effects that both drugs provide and their beneficial effects on health.
Pancreatic neuroendocrine tumors: classification, diagnosis and treatment – A review of the most frequent neuroendocrine tumors
Authors: Adamiec Dominika Karolina , Gonciarz Marta Justyna , Dąbrowska Anna , Zaliwska Dominika , Kienanh Do Monika , Strojny Agnieszka Aleksandra , Paduszyńska Natalia , Kraszkiewicz Adrianna , Kamińska Monika Anna , Czach Magdalena
Published: August 2024

Neuroendocrine tumors (NETs) are a heterogeneous group of tumors originating from cells of the dispersed endocrine system. They vary in their degree of differentiation and malignancy. They are primarily located in the gastrointestinal tract, pancreas, and lungs. This article will present the most common pancreatic neuroendocrine tumors, their specific characteristics, diagnostic methods including imaging diagnostics, and treatment options. NETs account for approximately 0.5% of all malignant tumors. Pancreatic neuroendocrine tumors include insulinoma, gastrinoma, glucagonoma, vipoma, and somatostatinoma. They secrete hormones specific to each type, chromogranins, and pancreatic polypeptide. However, only some of these tumors have a secretory function. They are usually well-differentiated tumors. Neuroendocrine tumors are difficult to diagnose due to their specific nature. They are typically diagnosed at an advanced stage, except for insulinoma. The most commonly used imaging methods are CT, MRI, PET, and SPECT. Treatment is extremely challenging due to symptoms caused by excessive hormone secretion. Usually, the first step in treatment is to alleviate symptoms. The only curative option is the removal of the tumor and its metastases. Unfortunately, this option is not available for many patients due to the late detection of the disease. Currently, many methods are used to slow the progression of tumors, including peptide receptor radionuclide therapy, mTOR inhibitors (everolimus), sunitinib, and chemotherapy. Detection and treatment are extremely difficult due to the specific nature of this group of tumors.
Can yoga be the answer? The positive aspects of practicing yoga across various medical conditions - a mini review
Authors: Rostkowska Weronika , Gajdzińska Natalia , Salwa Adam , Rutkowski Wojciech , Rzepka Maciej , Sztuba Karolina , Puchała Justyna , Rymaszewska Katarzyna , Starzomska Dominika , Basiura Karolina
Published: August 2024

Introduction: Yoga is well-regarded for its diverse health benefits, potentially impacting psychiatric, asthma, cardiovascular, autoimmune, and neurological conditions. It is also associated with broader positive effects such as improving quality of life, fitness levels, and psychosocial outcomes for individuals. Hatha yoga, widely practiced and studied worldwide, emphasizes physical postures (asana) and breathing exercises (pranayama), both of which contribute positively to overall mental and physical health.
Aim of the study: The aim of this study is to review the benefits of practicing yoga based on the latest scientific research. Both physical benefits, such as improved flexibility, strength, and balance, and psychological benefits, including stress reduction, anxiety relief, and enhanced overall well-being, will be analyzed. This paper aims to demonstrate how regular yoga practice can contribute to an improved quality of life and support the treatment of various health conditions.The mechanisms through which yoga impacts health will also be discussed, and the effectiveness of yoga will be compared with other forms of physical activity and relaxation techniques.
Material and methods: We have gathered the available materials and scientific reports, analyzing and summarizing them in a single study.
Conclusions: Yoga's diverse health benefits, supported by extensive research, highlight its potential as a valuable therapy for improving overall health and well-being across various medical conditions.
Propranolol in treating various symptoms associated with autism spectrum disorder (ASD)
Authors: Gajkiewicz Magdalena , Zaucha Radosław , Silldorff Julia , Fura Tomasz , Zając Małgorzata , Dudek Marcin , Felińska Zuzanna , Iszczuk Oliwia , Anczyk Stanisław
Published: August 2024

Introduction and purpose
This review provides an in-depth exploration of the pharmacology of propranolol, elucidating its mechanisms of action and clinical implications beyond its conventional indications, contextualizing propranolol’s role in ASD management.
State of knowledge
Propranolol is a non-cardioselective β-adrenergic receptor antagonist, commonly used among the population. Propranolol's mechanisms include reducing cardiac workload, vasoconstriction, and membrane stabilizing properties, which suggest its utility in managing anxiety. ASD, characterized by deficits in social interaction, communication, and repetitive behaviors, affects approximately 1 in 100 children globally. Symptoms often co-occur with anxiety and hyperarousal, linked to noradrenergic system alterations.
Review methods
Electronic searches were conducted between 6 and 13 May 2024 and included databases: Pubmed and Google Scholar. This review focuses on 4 trials that are limited to years 2016-2024.
Conclusions
Overall, propranolol shows promise in managing anxiety, enhancing social communication, improving cognitive performance, and addressing severe behavioral challenges in ASD. However, variability in response highlights the need for personalized treatment approaches. Further research is warranted to optimize dosing strategies and understand propranolol's mechanisms, contributing to more effective and tailored treatment options for ASD.
SEND inclusion in mainstream schools key to DfE reorganisation
Authors: Simpson Fiona
Published: August 2024

As new Prime Minister Keir Starmer finalises ministers, changes in the Department for Education teams suggest a focus on reforming support for children with special educational needs and disabilities
Exclusions rise adds impetus for change
Authors: Hayes Derren
Published: August 2024

Number of school pupils excluded and suspended rose steeply last year, reinforcing calls for more support for struggling children
Warning over state of finances
Authors: Simpson Fiona
Published: August 2024

ADCS president tells children's services leaders funding deal is essential to balance councils' books
Edge of care services
Authors: Gear Jacqueline
Published: August 2024

Jacqueline Gear, chief executive of Walk the Walk Family Support Service, outlines the value that effective commissioning of edge of care support can provide for children's social care departments
Family approach tackles child to parent violence
Authors: Jóźwiak Gabriella
Published: August 2024

Programme uses whole-family approach to work with children and young people who display violent and abusive behaviour towards their parents or carers
New government puts children's wellbeing at heart of its agenda
Authors: Hayes Derren
Published: August 2024

In the King's Speech, Labour outlined legislation to improve child mental health services, protect children educated outside of school, boost safeguards for vulnerable young people and raise education standards
Kenyan English idiomatic expressions: They may sound frequent but that’s not what corpus data show
Authors: Otiso Zipporah
Published: August 2024

Keen observers of Kenyan English usage will agree that idiomatic expressions such as put into consideration, rather than take into consideration, are certainly common in daily usage. The author of this paper set out to establish if that was indeed the case by having a sample of 122 respondents, all fourth-year university students, to choose between put and take. 77% of them chose put, which suggests that the expression put into consideration is indeed quite familiar to Kenyan English speakers. It was tested alongside another 19 idiomatic expressions. 17 out of the 20 were found to be familiar, though to varying degrees. But this familiarity was not reflected in corpus data from the International Corpus of English and the Corpus of Global Web-based English, where they were found to be rare. The same corpus data showed that this familiarity of the 20 expressions to Kenyan English speakers did not mean that they used them more frequently than their Standard International English counterparts. For example, the data showed that the “less familiar” take into consideration had more tokens in the Kenyan English components of the two corpora than the “more familiar” put into consideration. Nevertheless, the paper concludes that so-called Kenyan English idioms can still be claimed to be typical of Kenyan English, since they are practically absent from e. g. British English, its colonial ancestor.
The formal employment of family caregivers: reinforcing the familialisation of long-term care responsibilities?
Authors: Radlherr Julia , Österle August
Published: August 2024

The formal employment of family caregivers represents a rather uncommon form of organising long-term care but exists in diverse welfare states. Against this background, we examine how family carers experience a formalisation of previously unpaid care by drawing on two Austrian employment programmes and discuss their larger implications with regard to the (de)familialisation of long-term care responsibilities. Depending on the welfare state context, employment models might either provide freedom of choice with regard to the preferred care arrangement and strengthen a right to care or contribute to the enforcement of family care and thereby reinforce pressures on caregiving relatives.
Analysing legislatures using a feminist institutionalist lens
Authors: Kantola Johanna , Waylen Georgina
Published: August 2024

This is an exciting time in the development of the gendered study of legislatures, both theoretically and empirically. Over the last decade, we have seen innovative work employing new theoretical approaches, as well as a host of empirical studies in both the Global North and South. As a contribution, this state-of-the-art article brings together two elements that form a key part of this recent work: an important theoretical approach, feminist institutionalism (FI); and an important empirical case, the European Parliament (EP), which has been uniquely systematically and innovatively explored over a sustained period. The article explores how both elements can inform the other and shows how bringing them together adds to our understanding through the development and implementation of an analytical framework to structure the gendered analysis of legislatures, before considering how these insights might inform future research agendas in FI.
The evolution of the academic discourse on sustainability in the fashion industry: insights from a bibliometric analysis
Authors: Rita Sedita Silvia , Crespi Gomes Karolina , Pellegrin Vanessa
Published: August 2024

Over the past 15 years, the discourse surrounding the intersection of fashion and sustainability has transitioned from its nascent stages to garnering significant scholarly attention and research efforts, resulting in a substantial and rapidly expanding body of literature. In light of this, this article aims to conduct a comprehensive analysis of how academic research explores the combination of fashion and sustainability, referred to as ‘sustainable fashion’. To achieve this objective, a bibliometric analysis was undertaken to provide insights into the foundational works and emerging trends within sustainable fashion research. A total of 574 documents (comprising 463 articles, 12 books, 66 book chapters and 33 conference papers) spanning a 15-year period from 2007 to May 2022 were analysed using the Scopus database. The findings of the bibliometric analysis enabled us to: (1) identify foundational works, categorised into five thematic groups, encompassing slow and sustainable fashion, consumer perspectives on fast and eco-fashion, sustainable fashion supply chain management, sustainable business models and sustainable luxury; and (2) map the evolutionary trajectories of the field, delineating four stages in theory development, progressing from an initial focus on the creation of environmentally friendly products (eco-friendly approach) to embracing a holistic perspective of sustainability that encompasses supply chain dynamics, social considerations, and innovative business models. Based on these findings, we offer insights into potential future directions for the study of the sustainable fashion industry, which can inform decision-making processes in both private and public domains.
Drug Development Failure: how GLP-1 development was abandoned in 1990
Authors: Flier Jeffrey
Published: August 2024

Many factors determine whether and when a class of therapeutic
agents will be successfully developed and brought to market, and historians of science,
entrepreneurs, drug developers, and clinicians should be interested in accounts of both
successes and failures. Successes induce many participants and observers to document
them, whereas failed efforts are often lost to history, in part because involved parties are
typically unmotivated to document their failures. The GLP-1 class of drugs for diabetes
and obesity have emerged over the past decade as clinical and financial blockbusters,
perhaps soon becoming the highest single source of revenue for the pharmaceutical
industry (Berk 2023). In that context, it is instructive to tell the story of the first commercial effort to develop this class of drugs for metabolic disease, and how, despite
remarkable early success, the work was abandoned in 1990. Told by a key participant
in the effort, this story documents history that would otherwise be lost and suggests a
number of lessons about drug development that remain relevant today.
Cross-habitat utilization of fish in a tropical deltaic system as a function of climate variability and body size: Are mangroves fish nurseries in a tropical delta?
Authors: Sánchez-Núñez David Alejandro , Viloria Maestre Efraín , Rueda Mario
Published: August 2024

The temporal variability of fish habitat utilization is poorly understood in tropical deltaic systems due to high water turbidity, which limits visual censuses, and to the lack of long-term data incorporating climate variability events. We aimed to assess the influence of body size and El Niño Southern Oscillation (ENSO) variability on the cross-habitat utilization rate of 14 fish species of commercial relevance in the Ciénaga Grande de Santa Marta (CGSM). We estimated the utilization of mangroves and coastal lagoons based on relative catch frequencies from encircling gillnets used within a long-term catch monitoring program, and then tested for significant changes in each species’ habitat utilization as a function of body size and climate variability. Six species showed a high dependence on mangroves and four on coastal lagoons for most body size classes (including juveniles) and ENSO conditions. One species (Elops smithi) showed a high utilization of mangroves in some ENSO phases and body size classes, while three species showed a high utilization of both mangroves and coastal lagoons. Mangrove utilization by six species (Megalops atlanticus, E. smithi, Centropomus undecimalis, Mugil incilis, Mugil liza, and Ariopsis canteri) increased in larger body sizes at low depths, which usually occurs under dry ENSO conditions, when predatory risk is higher in coastal lagoons. Another species (Caquetaia kraussi) increased its mangrove utilization from the body size at which its feeding habits change. Mangroves and coastal lagoons are important nurseries and habitats for adults of the main commercial fish species in the CGSM. Seascape habitats and fringe/riverine mangroves must be conserved in tropical deltas to promote not only nurseries but also fish lifecycles.
Sex- and strain-dependent effects of ageing on sleep and activity patterns in Drosophila
Authors: Woodling Nathan
Published: August 2024

The fruit fly Drosophila is a major discovery platform in the biology of ageing due to its balance of relatively short lifespan and relatively complex physiology and behaviour. Previous studies have suggested that some important phenotypes of ageing, for instance increasingly fragmented sleep, are shared from humans to Drosophila and can be useful measures of behavioural change with age: these phenotypes therefore hold potential as readouts of healthy ageing for genetic or pharmacological interventions aimed at the underpinning biology of ageing. However, some age-related phenotypes in Drosophila show differing results among studies, leading to questions regarding the source of discrepancies among experiments. In this study, I have tested females and males from three common laboratory strains of Drosophila to determine the extent to which sex and background strain influence age-related behavioural changes in sleep and activity patterns. Surprisingly, I find that some phenotypes–including age-related changes in total activity, total sleep, and sleep fragmentation–depend strongly on sex and strain, to the extent that some phenotypes show opposing age-related changes in different sexes or strains. Conversely, I identify other phenotypes, including age-related decreases in morning and evening anticipation, that are more uniform across sexes and strains. These results reinforce the importance of controlling for background strain in both behavioural and ageing experiments, and they imply that caution should be used when drawing conclusions from studies on a single sex or strain of Drosophila. At the same time, these findings also offer suggestions for behavioural measures that merit further investigation as potentially more consistent phenotypes of ageing.
Investigating a Technique for Forming Paracetamol-Surfactant Micelles
Authors: Zhang Jialiang
Published: August 2024

Micelles are spheres of molecules that enhance the solubility and stability of low-solubility drugs by increasing their interactions with water. These structures possess hydrophobic (water repelling) cores and hydrophilic (water attracting) exteriors, making them suitable carriers for such drugs. They form from amphiphilic substances, which contain both hydrophobic and hydrophilic regions. Sodium lauryl sulfate (SLS) is an example of an amphiphilic substance.This investigation demonstrates the feasibility of encapsulating paracetamol, a test drug, in SLS micelles in solution. Standard laboratory apparatus was used for synthesis, and Nuclear Magnetic Resonance (NMR), an analytical technique, was utilized for analysis. The findings confirmed successful micelle formation using the synthetic technique applied. This supports the potential of micelle encapsulation as a method to enhance the solubility of pharmaceuticals, thereby improving their absorption by the body.
Xenogeneic Protein-Free Cultivation of Mesenchymal Stromal Cells – Towards Clinical Applications
Authors: Stehlík David , Pytlík R. , Rychtrmocová H. , Kideryová L. , Veselá R. , Kopečný Z. , Trč T. , Trněný M.
Published: August 2024

We have studied a rapid cultivation method for human mesenchymal stromal cells based on CellGroTM medium and human serum, supplemented with insulin, ascorbic acid, dexamethasone, epidermal growth factor, platelet-derived growth factor BB, macrophage colony-stimulating factor and fibroblast growth factor 2. This study has shown that rapid expansion of human multipotent mesenchymal stromal cells using human serum could not be achieved without addition of growth factors. Furthermore, we have found that insulin and, quite probably, epidermal growth factor may be omitted from our formula without loss of colony-forming capacity or total cell yield. On the other hand, dexamethasone, ascorbic acid and fibroblast growth factor 2 were necessary for the growth and colony-forming capacity of multipotent mesenchymal stromal cells, while platelet-derived growth factor BB prevented their differentiation into adipogenic lineage. Moreover, multipotent mesenchymal stromal cells cultivated in our system expressed higher levels of bone morphogenetic protein 2, but not bone morphogenetic protein 7, than cells cultivated in α-MEM with foetal bovine serum. This shows that our system promotes differentiation of mesenchymal cells towards osteogenic and chondrogenic lineages, making them more suitable for bone and cartilage engineering than cells grown in conventional media. Furthermore, we have proved that these cells may be conveniently cultivated in a closed system, in vessels certified for clinical use (RoboFlaskTM), making the transfer of our cultivation technology to good clinical practice easier and more convenient.
Expression of Wnt 3a, β-Catenin, Cyclin D1 and PCNA in Mouse Dentate Gyrus Subgranular Zone (SGZ): a Possible Role of Wnt Pathway in SGZ Neural Stem Cell Proliferation
Authors: Kumar D. U. , Devaraj Halagowder
Published: August 2024

In mammalian dentate gyrus subgranular zone, the addition of new neurons throughout adult-hood is a remarkable form of structural plasticity. Yet, the molecular controls over subgranular zone neural stem cell proliferation, survival, and differentiation are poorly understood. In this study we analysed the expression of Wnt 3a, β-catenin, cyclin D1 and proliferating cell nuclear antigen in mouse subgranular zone to elucidate the involvement of Wnt pathway in subgranular zone neural stem cell proliferation. We performed immunohistochemistry and RT-PCR for the above molecules on adult and postnatal developing hippocampal tissues of mice, respectively. RT-PCR analysis showed a gradual increase in expression of mRNA of Wnt 3a, β-catenin, cyclin D1 and proliferating cell nuclear antigen as the postnatal hippocampus developed, and immunohistochemical analysis showed a highly positive immunoreactive expression for Wnt 3a, β-catenin, cyclin D1 and proliferating cell nuclear antigen in the subgranular zone cells. Together, our data suggested that the Wnt pathway is activated in subgranular zone and could play an important role in regulating subgranular zone neural stem cell proliferation in mouse hippocampus.
Factors Affecting Voluntary Switching of Public Accounting Firms: What is the Role of Auditor Reputation?
Authors: Naibaho Eduard Ary Binsar , Amanda Silvisia
Published: August 2024

Purpose : The research examines the effects of audit opinion, company growth, and financial distress on voluntary public accountant firms’ switching, with the auditor’s reputation acting as a moderating variable.
Method : Voluntary Public Accountant Firms Switching and Audit Opinion in this study are measured using dummy variables. Company Growth is measured through a proxy of sales changes, and Financial Distress is gauged using the Debt-to-Equity Ratio. The study uses a purposive sampling method and secondary data from 76 companies in the ASEAN 5 region, Japan, and Australia, all falling under the Consumer Staples sector in the S&P Capital IQ, during 2013-2022. The study uses a regression logistic model.
Findings : The research indicates that audit opinion, company growth, and financial distress do not significantly impact voluntary public accountant firms’ switching. The study also demonstrates that an Auditor’s Reputation cannot moderate the impact of Audit Opinion, Company Growth, and Financial Distress on Voluntary Public Accountant Firms Switching.
Novelty : Employing two periods of auditor switching, each spanning five years, to comprehensively examine the voluntary auditor switching phenomenon.
Neoconservative legal strategies against reproductive rights in Brazil
Authors: Castilho Ela Wiecko Volkmer de , Almeida Tânia Mara C de , Wardi Clara Frota
Published: August 2024

The article presents some strategies used by religious fundamentalists within the administrative norms of health and public safety to construct the social and legal representation of the fetus and even the embryo as subjects with rights superior to those of the pregnant woman. It also addresses the naturalization and acceptance of this idea by the justice system, paving the way for the approval of the "Statute of the Unborn," a proposal advocated for years by conservatives in Brazil, and for the prohibition of any legal allowance for abortion. It particularly focuses on Bill 1904 of 2024, currently under consideration in the Chamber of Deputies.
Effect of phosphoric fertilization on mycorrhizal colonization in corn in the colombian caribbean
Authors: Cabrales-Herrera Eliecer M , Estrella-Cantero Germán F , Ayala-Cárcamo Jesús
Published: August 2024

Plants require essential nutritional elements for their growth and development, including phosphorus, but this in the soil is usually deficient and slow in mobility, so biological practices must be used to make the uptake of this element by plants more efficient, for which, mycorrhizal symbiosis could greatly contribute to the uptake of phosphorus. The symbiosis becomes more effective when the soil contains low levels of phosphorus in the soil, however, these low contents do not favor the development of the corn crop. In response to this, this research was proposed, which was developed in semi-controlled conditions at the University of Córdoba, warm climate, in which different doses of phosphorus were evaluated (0, 5, 10, 20, 30, 40, 50 kg/ha) and the degree of colonization and vegetative development of the corn crop was evaluated in a soil with low nutritional supply and especially phosphorus (5 mg/kg). Corn of the ICA V 109 variety was used, in a complete randomized design, seven treatments with three repetitions were evaluated. The variables height, stem diameter, leaf area, wet and dry biomass and degree of colonization (mycorrhization) were evaluated. It was found that phosphorus is a limiting element in the growth of the corn plant and also influences the degree of mycorrhizal colonization. It was concluded that phosphorus fertilization has an inverse effect on mycorrhizal colonization in corn cultivation in edaphoclimatic conditions of Montería-Colombia. However, the amount of phosphorus available in the soil is directly proportional to the growth of this cultivar.
Advanced strategies for mental augmentation with hyaluronic acid – a case series using the profile approach
Authors: Eduardo Avelar Luiz , Haddad Alessandra , Carnevali Ana CN , Guerra Isabela , Muñoz-Lora Victor R , Germani Marcelo
Published: August 2024

Objective: Hyaluronic acid (HA), due to its high reversibility, low incidence of adverse events, and patient acceptance, is a viable option for correcting mild to severe retrognathia. This work aims to systematize and suggest non-surgical options that impact facial profile through the ProT technique. Methods: Depending on the level of retrognathia, HA injections are administered in varying depths, with severe cases also requiring neuromodulator treatment. Proper injection techniques and materials are recommended to enhance treatment effectiveness and durability. Results: The case series showed significant improvements in mental region projection and definition, with 40%, 50%, and 70% enhancements for cases 1, 2, and 3, respectively. Case 2 also had a 15% increase in the distance from the oral commissure to the mandibular base and a 3.25 cc volumetric gain in the mental region. These results indicate substantial improvements in facial aesthetics following the intervention. Limitations: We can consider individual anatomical variations, tissue response, and the clinician´s ability as limiting factors for technique reproducibility. Conclusion: The Profile Technique (ProT) utilizes HA gels and, optionally, neuromodulators tailored to each patient's facial profile to effectively correct retrognathia. This approach results in significant improvements in facial aesthetics while ensuring safety, making ProT a minimally invasive and effective method for enhancing facial harmony.
Improvement of skin laxity and the lifting effect with the use of poly-l-lactic acid Rennova Elleva®
Authors: Gonzaga Marisa , Arruda Bruno Priscila , Sigrist Rosa , Gasques Luciana
Published: August 2024

Poly-L-lactic acid (PLLA) is a biocompatible, absorbable, immunologically inert polymer that induces neocollagenesis. In the late 1990s, it began to be used as a bio-stimulator not only for the treatment of skin aging and other causes of facial lipoatrophy, but also as cosmetic indications in non-facial areas to improve skin quality. About two years ago, a new presentation of poly-L-lactic acid was launched in Brazil under the name RennovaElleva®. The product RennovaElleva® has been approved by ANVISA for the treatment of skin laxity, leading to the restoration of facial volume and tissue repositioning on the face and body. Each vial contains 210 mg of poly-L-lactic acid (PLLA), carboxymethylcellulose (132 mg) and mannitol (178 mg). It comes in the form of a lyophilized powder that should be reconstituted in 16 ml of final diluent volume. In this article, we describe the results obtained using the vector application technique, which aimed at improving skin laxity and facial contour with a lifting effect in ten female patients, with two sessions spaced 45 days apart. In addition to the clinical results achieved at 3 and 6 months after the end of treatment, safety and efficacy outcomes were analyzed over this period. We also discuss the distinctive characteristics of this new presentation.
Circadian cycle and impact on metabolic health of adults
Authors: Vanina Garro Bustos Jessica
Published: August 2024

Currently overweight and obesity are an epidemic and represent a global public health problem. They are related to a greater probability of developing chronic diseases, which are increasing and represent a significant burden on the health system. A diet synchronized with the circadian cycle and based on natural foods with a low glycemic index and healthy fats has gained considerable scientific and popular impact; and they are effective practices for the treatment of excess weight and its comorbidities. The objective was to analyze the impact of CC (Circadian Cycle) synchronization on the metabolic health (biochemical and anthropometric parameters) of overweight and obese people. A correlational, longitudinal study was carried out. 80 individuals of both sexes between 18 and 59 participated for ten months. The sample was made up of 32.5% men and 67.5% women. 96% of the individuals registered weight loss. Regarding the percentage of body fat, 55% started with a “very high” diagnosis, and at the end of the period it was reduced to 30%. 75% began with a waist circumference diagnosis of “very high risk” and this was modified to 55%. Regarding total cholesterol, 40% decreased its value compared to the initial one; Regarding LDL, 85% decreased the value to normal parameters; In relation to triglycerides, 95% positively modified their values. Synchronized feeding with CC weight loss, a decrease in abdominal fat mass, a decrease in WC, and positively influences the biochemical parameters of the overweight and obese people analyzed, to a greater extent in males and females in young adults (p˂0.05).
Aesthetics of costume and make-up for stage and screens: a contextual discuss on AMIRI festival of Agwatashi, Obi Local Governent Nasarawa State
Authors: Apeh Apeh Columba , Osumanyi Okugya
Published: August 2024

In theatre and film (screen) productions, costume and makeup designers make the aesthetics choice of what the characters wear based on the historical background of the production. Students’ lack of interest in technical theatre is affecting the quality of costume and makeup in production design. Exposure to social media is also affecting the style of costume and makeup for students’ productions. This paper is theorized based on the design aesthetic considerations of Albright, William and Lee which are appropriateness, individuality and unity. The research adopts content analysis methodology in conducting the study. The article finds that proper costuming and make up of characters enhance aesthetics grandeur of production as exemplified in Amiri festival of Alago community in Nasarawa State, Nigeria. The article concludes that costume alone does not guarantee the success of a production so also a poorly costumed character’s interpretation and line delivery is affected in a production. When, when properly coordinated with other production elements, costumes and makeup enhanced aesthetic functionality to screen and stage productions. The article recommends that students research and visit locale if possible for truthful depiction of costumes. There is need to engage specialists and well trained costumiers to handle practical in the tertiary institutions. The culture of dress and technical rehearsal should be revived to ensure that visual and performance elements are harmony in production before opening night. Students in should be motivated in technical theatre courses serious because they can be established in fashion business and event management.
Contemporary dress in and modernization from the axis of Atatürk and the Republic
Authors: Imre H Meryem
Published: August 2024

Clothing is a social phenomenon that shows the existence of human beings on earth and reveals its influence more broadly with every period and change. It has a structure that strengthens communication with the whole of society and individuals. This form of communication improves social position and intercultural interaction botj intellectually and visually. One of the important building blocks of contemporary and modern social life, which started with the establishment of the Republic of Türkiye, is the clothing revolution and, in parallel, the modernization of the individual's image. Atatürk changed the social position of the Turkish people and restructured Turkish society with the reforms he carried out with a progressive perspective that was free from prejudice and took the West as an example. The first visual impact of the modernization process being established and adopted on solid foundations was the clothing revolution. Clothing combined with the sociological and psychological sides of society within the phenomenon of fashion has become the face of of innovation and development. Mustafa Kemal Atatürk emphasized his leadership qualities with his forward-thinking, innovative approaches and contemporary clothing. He used his clothing style as a means of communication, affecting the development and change of individuals. During the Republican period, Turkey followed a modern method that supported fashion development and national identity. This method, which will contribute to the construction of national identity, was supported by revolutions. After the clothing revolution that took place under the leadership of Mustafa Kemal Atatürk between 1931 and 1940, the foundations of Turkish Fashion were laid and the contemporary clothing approach for the Republican period began to take shape. In our study, a literature study of the period was conducted and clothing forms were examined through Atatürk's photographs. The way the leadership role in social changes is visually communicated through clothing has been examined. The important features of contemporary clothing in the Republican period, Mustafa Kemal Atatürk's perspective on creating a contemporary individual and society, are explained through the compilation method.
Tensor fascia lata graft with fat graft used as a wrist watch sling for ectropion release in a complex facial scar
Authors: Singh Taruna , Chattopadhyay Debarati , Kapoor Akshay , Behl Ridima
Published: August 2024

The face is a vital structure with uttermost importance aesthetically and functionally. Complex facial scar is a surgical challenge due to scarred and fibrotic surrounding tissue with unpredictable healing. We describe a case of a 50-year-old male with multiple times operated scars over his face. In this technique, we used dermis fat grafting attached to tensor fascia lata designed as a wristwatch. The tensor facia lata was designed as a dial of a watch which was attached on both sides by dermis fat graft like a wristband. Both tissues were used in a single stage to manage an intractable complex facial scar with ectropion. There were no significant complications post-operatively.
What invasive species do EMAPi participants study - a sequel to Pyšek et al. 2019
Authors: Vall Hay John Du
Published: August 2024

Since 1992, 16 conferences have been held on the theme “Ecology and Management of Alien Plant Invasions” (EMAPi) around the world in which more than 650 identified species have been the subject of presentations. At least one presentation on 31 of the 36 species considered to be among the most invasive plant species worldwide has been made. Reynoutria japonica Houtt., Impatiens glandulifera Royle and Heracleum mantegazzianum Sommier & Levier were the species with the greatest number of studies but the majority of studies present data on only one species. Studies on the identified species have been done in 102 countries or territories around world. This reflects the different venues of the conferences and the origin of the participants in the meetings. In this evaluation, studies on the presence of identified invasive species were slightly more frequent than studies on control and management or ecology but there are many general presentations focusing on management of invasive plant species. The majority of the studied species were terrestrial with a perennial life style and were herbaceous. The majority of these species also had the capacity for vegetation spread or regrowth. EMAPi presentations are a representative subset of research on invasive plant species.
A journey of research and action: Tatiana Chagas Memória Municipal School, Jardim Maravilha, Guaratiba, Rio de Janeiro
Authors: Paula Muniz Evânia de , Félix da Costa Carlos Eduardo
Published: August 2024

This work shared the experiences of a research teacher at the Tatiana Chagas Memória Municipal School, located in Jardim Maravilha, Guaratiba/RJ. It took place from June 19 to December 20, 2023. The action research proposed an education based on the pillars of Human Rights, Rights of Nature and Inclusion, advocating a flexible approach that incorporated various languages and tools. The methodology adopted had as its central axis Art-Based Research (PEA), which incorporates several approaches. This research was guided by the theory proposed by economist Alberto Acosta in his book "Bem Viver" (2016), "Carta da Terra" (1992), and by Edward Wilson's concept of Biophilia (1984). To make the research viable, tools such as Design Thinking and the Affective Tree were used. With the aim of meeting the Sustainable Development Goals (SDGs).