bluuebunny/crossref_metadata_2025 huggingface dataset:
Conclusion
Authors: Rendell James
Published: June 2023

This chapter addresses future studies into post-TV horror and the utilization
of abject spectrums beyond horror. The chapter considers post-TV
horror’s transnational facets and the need to research non-Anglophonic
horror television, before signalling how media’s general digitization
prompts further consideration of televisuality structuring other horror
media. Positioning fans as active creatives, the chapter considers Creepypastas
as grassroots digital folktales and horror media that have their own
fandoms. The chapter explores how abject spectrums can be applied to
and complicated by horror videogame playing, whist pedagogical settings
can paratextually direct students’ abject spectrums. Finally, while abject
imagery displays strong affinities with horror iconography and themes,
the chapter evidences other genre media that can galvanize audiences’
abject spectrums.
Status of Lake Taal Fisheries Amid Volcanic Threat and Covid 19 Pandemic : A Preliminary Study
Authors: Mutia Maria Theresa M , Magistrado Myleen L. , Muyot Myla C. , Alcazar Maria Teresa M. , Tordecilla Benjie D. , Garciaa Lilian C. , Merilles Ma Lourdes D.
Published: June 2023

The status of fishery resources of Lake Taal – the third largest lake in the Philippines was assessed to provide updated information on the capture fisheries following the Taal Volcano eruption and COVID-19 pandemic in 2020. Using the methodology of the National Stock Assessment Program of NFRDI, this study was conducted from January to December 2021 at 15 fish landing sites around the lake. In addition, interview schedules of 100 fisherfolk respondents from 11 coastal municipalities were also conducted to assess the effect of the volcanic eruption and pandemic on the livelihood of fisherfolk. Annual capture fisheries production was estimated at 1,004.14 MT. About 47% percent of these comprised the endangered freshwater sardine Sardinella tawilis while 31% are introduced species, and 22% migratory and/or native species. Current fisheries inventory showed that the number of fishers, fishing gears and fishing boats increased compared to 2018 inventory. The increased number of fisherfolk showed that more residents became dependent on the fishery resources of the lake. In the aftermath of volcanic eruption, reported impacts include reduction of fishing activity due to damaged gear and boat, fear of open water fishing, and reduction in demand for fish due to “unsafe” claims. Though many boats and gear were damaged in the 2020 volcanic eruption, passive or stationary fishing gears such as fish traps and fish corrals noticeably increased. During the peak of the community quarantine due to COVID-19, movement of fisheries products were hindered which led to the disruption of supply chain, and reduction of fishing activities due to lesser demand. Though there were times when fishing activities were halted due to recurring volcanic threat and pandemic, sustaining food and livelihood are what drive the local fisherfolk to learn to live and adjust adaptively to the current situation.
The Distribution of Invasive Tilapia Throughout A Tropical Man-Made Lake With Special Reference to Temengor Reservoir, Malaysia
Authors: Hamid Muzzalifah Abd , Sahb Amir Shah Ruddin Md , Nor Siti Azizah Mohd , Mansor Mashhor
Published: June 2023

With a surface area of 15, 200 ha, the Temengor Reservoir, in the northwestern state of Perak was selected among other lakes in Malaysia for the development of a large tilapia aquaculture facility in 2008 due to its favourable environmental conditions.  Tilapia has never been recorded at Temengor Reservoir prior to the establishment of this facility. However, preliminary observations in a previous study detected tilapia species in the natural waters of this lake, strongly suggesting these were escapees from the floating cages which had invaded the natural waters. Following that, a study was conducted to assess the distribution of these escapees throughout the Temengor Reservoir. The cultured tilapias are easily recognizable with elongated mouth and body, and long caudal fin. The sampling was conducted using gill nets. The distribution of the escaped tilapia throughout the Temengor Reservoir was mapped based on previous data and current data on the fish checklist conducted at different sampling points of this lake, and the occurrence (presence/absence) of escaped tilapia was recorded. A comparative analysis was conducted at several number of points among three sampling areas, according to the radii from the fish cage facility; <5km (S1), 5-15km (S2), and >15km (S3). The ANOVA showed significant differences (p<0.05) in Catch per Unit Effort (CPUE) weight between the three sampling areas. As tilapia is a highly successful global invasive species, the presence of tilapia at these and other locations at Temengor Reservoir should be rigorously monitored. Complete eradication of tilapia in the lake is of high urgency. We recommend intensive targeted fishing of the species in the vicinity of the cages and biological control by native predators to preserve and conserve the native fish species at Temengor Reservoir.
FORMULASI DAN EVALUASI SEDIAAN TABLET HISAP DARI EKSTRAK ETANOL BIJI KOPI ARABIKA (Coffea arabica L.) JAVA PREANGER SEBAGAI ANTIOKSIDAN
Authors: Handayani Retty , Nurul Auliasari  , Hisni Uswatun Hasanah
Published: June 2023

Arabica coffee (Coffea arabica L.) Java Preanger is the best coffee from West Java which is better known internationally as Java Preanger. One of the secondary metabolites found in Arabica coffee beans and efficacious as an antioxidant is chlorogenic acid. Lozenges were made by wet granulation method with various concentrations of coffee extract 5%, 10% and 15%. The resulting preparation was then evaluated for its physical and antioxidant activity. Physical evaluation includes organoleptic tests, weight uniformity, size uniformity, hardness, friability, frictionibility and disintegration time. Meanwhile, the antioxidant activity test was carried out using the ABTS method. Based on the results of the physical evaluation, the formulation that meets the requirements is formula 3 (F3) with a coffee bean extract concentration of 15% and has the highest antioxidant activity with an IC50 value of 27.915 ppm.
AKTIVITAS ANTIBAKTERI FRAKSI ETIL ASETAT DAUN JAMBU AIR (Syzygium aqueum) TERHADAP Shigella dysentriae
Authors: Pupunk Fajriyani  , Aulia Nur Rahmawati  , Novena Yety Lindawati
Published: June 2023

Shigella dysentriae is a genus of Shigella which has a high percentage of causing dysentery by 25%. The ethyl acetate fraction of guava leaves has potential as an antibacterial because the amount of compounds that provide antibacterial activity are more attracted in this solvent. The purpose of this study was to see the potential for inhibition of the ethyl acetate fraction of guava leaves (Syzygium aqueum) at each variation of its concentration against the bacterium Shigella dysentriae. The ethyl acetate fraction was obtained by liquid-liquid fractionation. The ethyl acetate fraction was tested in the zone of inhibition against Shigella dysentriae with various concentrations of 12.5%, 25%, 50%, and 100%, Ciprofloxacin positive control and 100% DMSO negative control. The data obtained were processed using One Way Anova with a 95% confidence level. The results of phytochemical screening of the ethyl acetate fraction of guava leaves showed positive for flavonoids, alkaloids, tannins, saponins, and steroids. Inhibition test of ethyl acetate fraction of guava leaves against bacteria Shigella dysentriae had the smallest inhibitory power at a concentration of 12.5%, the inhibitory power was 6.3 mm; 25% concentration of 15.3 mm; 50% concentration of 16.7 mm; and the concentration of 100% the largest inhibitory power was 18.4%. The results of the antibacterial inhibition of the ethyl acetate fraction of guava leaves had a significant difference in each concentration with a significance value (p <0.05).
infancias de las post pandemia
Authors: Duek Carolina , Moguillansky Marina
Published: June 2023

Este artículo presenta una propuesta para analizar las consecuencias, cambios y permanencias del aislamiento durante la pandemia y la post pandemia en relación con las infancias. A partir de una revisión de los estudios publicados construimos una agenda de investigación para las infancias de la post pandemia atendiendo a diferentes dimensiones que consideramos urgente estudiar. La agenda se organiza en cinco núcleos de problemas entrelazados: la sociabilidad y socialización de las infancias; las desigualdades educativas y el aprendizaje; la relación con las pantallas; los problemas de alimentación y el déficit de actividad física. Luego, se despliegan las líneas de la agenda de investigación que proponemos para comprender la relación entre infancias, pandemia y postpandemia recuperando esos cinco núcleos. Proponemos una perspectiva atenta a los aspectos comunicacionales y emocionales que será transversal a todo el desarrollo y que permitirá dar cuenta de las complejidades que atraviesan las infancias contemporáneas.
mujeres en la Copa Mundial de Futbol de 1978 en Argentina
Authors: Carricaberry Manuela
Published: June 2023

Este trabajo analiza las construcciones discursivas utilizadas en la prensa argentina durante el Mundial de fútbol de 1978 con el objetivo de explorar la relación entre lenguaje y poder. El estudio se centra en las publicaciones periódicas Para Ti y Gente, considerándolas como vehículos activos que influyen en la conformación de espacios sociales y en la toma de decisiones políticas y de interés público. Como marco de análisis se retoma la obra de Jacques Rancière en relación al poder simbólico de la comunicación como producto cultural estratégico. Así, partiendo del estudio de la figura de la mujer durante el Mundial, se diferencian posicionamientos individuales y colectivos de subjetivación e identificación y se indaga el rol de los medios en la reproducción de prácticas hegemónicas, identificando también momentos políticos de ruptura en la jerarquía de representación y saber en la repartición de la experiencia de lo común.
Temporal occurrence and species composition of birds on artificial feeding sites maintained for game mammals in the Dinaric Mountains, Slovenia
Authors: Bordjan Dejan , Soultan Alaaeldin , Jerina Klemen
Published: June 2023

Artificial feeding is a widely used management tool, but it often attracts nontarget species, including birds, to permanent feeding sites. This study used camera traps to monitor the presence of birds at selected sites used for bear management in Dinaric forest. A large number of bird species (35) were recorded, representing roughly half of all species breeding in the surrounding area. These species were grouped based on monthly and hourly presence, and corresponded to food groups, with most belonging to granivores or scavengers. Some species, such as Pigeons (Columba sp.), Raven (Corvus corax) and Buzzard (Buteo buteo), adapted their presence to the availability of food at the feeding sites, while others were not affected by this. Both Chaffinches (Fringilla coelebs) and Jays (Garrulus glandarius) frequented the feeding sites, but their temporal presence was influenced by their biology rather than by food availability. The Sparrowhawk (Accipiter nisus) also adapted its presence to food availability, and its presence was closely associated with that of the Jay. This study confirms the temporal differences in the use of feeding sites by birds and mammals, which is likely due to their different biology and past management. This can be used to make wildlife management more efficient and reduce the undesirable effects of artificial feeding.
Progressive and Regressive Securitisation: Covid, Russian Aggression and the Ethics of Security
Authors: Diez Thomas
Published: June 2023

This paper contributes to the debate about the normative assessment of securitisation in light of Covid-19 and the Russian invasion of Ukraine. It develops the distinction of progressive and regressive securitisation. In doing so, it emphasises the processual, contextual and ambiguous nature of securitisation. I suggest that progressive securitisation is closely linked to the solidarisation, whereas regressive securitisation implies the pluralisation of international society. The two cases of Covid-19 and Russia illustrate that international order has increasingly been characterised by regressive securitisation and a pluralisation of international society, despite possible alternatives, such as a transnational response to the spread of Covid-19. They have thus contributed to the further demise of the post–Cold War liberal order, which despite its problems, has involved a re-orientation of security away from state territory and national identity as the core referent objects. I end with a plea to take the ethics of security more seriously again, and in particular to scrutinise the ways in which our own behaviour reinforces regressive securitisation.
Global impacts of aviation on air quality evaluated at high resolution
Authors: Eastham Sebastian D. , Chossière Guillaume P. , Speth Raymond L. , Jacob Daniel J. , Barrett Steven R. H.
Published: June 2023

Abstract. Aviation emissions cause global changes in air quality which have been estimated to result in ~58,000 premature mortalities per year, but this number varies by an order of magnitude between studies. The causes of this uncertainty include differences in the assessment of ozone exposure impacts and in how air quality changes are simulated, and the possibility that low-resolution (~400 km) global models may overestimate impacts compared to finer-resolution (~50 km) regional models. We use the GEOS-Chem High Performance chemistry-transport model at a 50 km global resolution, an order of magnitude finer than recent assessments of the same scope, to quantify the air quality impacts of aviation with a single internally consistent, global approach. We find that aviation emissions in 2015 resulted in 21,200 premature mortalities due to particulate matter exposure and 53,100 due to ozone exposure. Compared to a prior estimate of 6,800 ozone-related premature mortalities for 2006 our estimate is increased by 5.6 times due to the use of updated epidemiological data which includes the effects of ozone exposure during winter, and by 1.3 times due to increased aviation fuel burn. The use of fine (50 km) resolution increases the estimated impacts on both ozone and particulate matter-related mortality by a further 20 % compared to coarse-resolution (400 km) global simulation, but an intermediate resolution (100 km) is sufficient to capture 98 % of impacts. This is in part due to the role of aviation-attributable ozone, which is long-lived enough to mix through the Northern Hemisphere and exposure to which causes 2.5 times as much health impact as aviation-attributable PM2.5. This work shows that the air quality impacts of civil aviation emissions are dominated by the hemisphere-scale response of tropospheric ozone to aviation NOx rather than local changes, and that simulations at ~100 km resolution provide similar results to those at two times finer spatial scale.
The antibiotic bead pouch – a useful technique for temporary soft tissue coverage, infection prevention and therapy in trauma surgery
Authors: Rupp Markus , Walter Nike , Szymski Dominik , Taeger Christian , Langer Martin Franz , Alt Volker
Published: June 2023

Abstract. Soft tissue defects resulting from trauma and musculoskeletal infections can
complicate surgical treatment. Appropriate temporary coverage of these
defects is essential to achieve the best outcomes for necessary plastic soft
tissue defect reconstruction. The antibiotic bead pouch technique is a
reasonable surgical approach for managing temporary soft tissue defects
following adequate surgical debridement. This technique involves the use of
small diameter antibiotic-loaded bone cement beads to fill the dead space
created by debridement. By applying antibiotics to the bone cement and
covering the beads with an artificial skin graft, high local dosages of
antibiotics can be achieved, resulting in the creation of a sterile wound
that offers the best starting position for soft tissue and bone defect
reconstruction. This narrative review describes the rationale for using this technique,
including its advantages and disadvantages, as well as pearls and pitfalls
associated with its use in daily practice. In addition, the article provides
a comprehensive overview of the literature that has been published since the
technique was introduced in surgical practice.
PERANCANGAN BUKU ILUSTRASI PARTIALITY OF OPTIONS KINA DALAM UPAYA MEMPERKENALKAN STOIKISME
Authors: Valentino Dion Eko , Ramadhan Raden Haya Ula
Published: June 2023

Partiality Of Options Kina ini mengangkat isu gangguan kesehatan, kecemasan, dan penyelesaian masalahnya melalui aliran filsafat stoikisme. segala alur cerita dan karakter pada Partiality Of Options ini bersifat fiktif. Stoikisme adalah sebuah filsafat Yunani kuno yang dikembangkan pada abad ke-3 SM oleh Zeno dari Kition dan berkembang menjadi sebuah aliran filsafat yang populer. Stoikisme bertujuan untuk membantu manusia mencapai kebahagiaan dan kebijaksanaan melalui pengendalian emosi, penilaian yang benar tentang apa yang dapat dan tidak dapat dikontrol, dan hidup sesuai dengan kebenaran moral. Stoikisme juga mengajarkan bahwa hanya hal-hal yang dapat dikontrol yang layak dikhawatirkan. Demi tersampaikannya pesan mengenai informasi terkait stoikisme Partiality Of Options Kina ini dikemas menjadi metafora dan dibuat dengan bentuk ilustrasi.
Composite Laminates for Aerospace and Packaging Fields
Authors: Rameswara Reddy Y.
Published: June 2023

Composite materials have become increasingly popular and widely used in the present world due to their unique combination of properties that cannot be achieved by any single material. In the current study the mechanical properties of composite laminates (Jute, palm and banana fibers) were fabricated by varying groundnut husk and seashell powders quantities (5, 10, 15 and 20gms) in epoxy resin using hand layup technique. In according to the ASTM standards, a mixture of Epoxy (LY556) and Hardener (araldite) HY951 is used. The ratio of epoxy to hardener is 10:1. The material will be properly mixed for some time before being used to create laminates. Samples were fabricated with different compositions of jute, palm and banana fibers. Tensile, Compression properties of laminates were analyzed by testing composite laminates on universal testing machine. In this context the weight ratio of groundnut husk to seashell powder is 2:1. Analysis states that both the powders have impact on the mechanical properties of laminates. The impact of groundnut husk powder is slightly more on the laminates mechanical properties (tensile, compression) when related to seashell powder.
Bibliotecas universitarias y formación permanente de las personas mayores: análisis de una experiencia en un entorno digital
Authors: Heredia-Sánchez Fernando
Published: June 2023

Se analiza una experiencia formativa desarrollada en un entorno digital, dirigida a mayores de 55 años e impartida desde una biblioteca universitaria. Su objetivo fue contribuir a la formación en competencias mediáticas e informacionales mediante un taller sobre el uso del catálogo, el acceso a recursos electrónicos y la participación en redes sociales y canales de comunicación. La participación fue del 60,49% del total de inscritos, con un cumplimiento de las expectativas de 4,68 sobre 5. Algunas limitaciones fueron la fecha de realización de la actividad, la brecha de género y no haber ofrecido formación complementaria. Se concluye que la participación de las bibliotecas universitarias en la formación de personas mayores tiene valor estratégico y se alinea con los Objetivos de Desarrollo Sostenible relacionados con la inclusión, el acceso a la información, el aprendizaje permanente, la lucha contra las desigualdades y la extensión del uso de las tecnologías.
Terminology applied in the study of user information when aimed at visually impaired people
Authors: Vieira da Silva Bastos Karolina , Kafure Munoz Ivette , Neves Raposo Patrícia
Published: June 2023

Society comprises unique individuals; this is a human condition. Individuals think differently, act differently, and feel with varying intensities; and all this is because human beings live and make sense of the world in their own unique ways. Despite these differences, some terminologies help in expression and communication. From this perspective, this article aims to present the terminology for visually impaired people in the study of information users, based on the literature of information science and related areas. This is a qualitative study that uses a bibliographic method, associating conceptual aspects relevant to the topic. The study shows that terms and concepts should be defined for users with disabilities, and that user studies should be focused on people's individuality and consider their experiences, needs, and expectations, thus paving the way for a holistic perspective.
Disponibilidad de los libros electrónicos de la bibliografía recomendada en bibliotecas universitarias. El Grado en Información y Documentación online de la Universidad de León
Authors: Arroyo Vázquez Natalia
Published: June 2023

Las bibliotecas de universidades que imparten titulaciones online o a distancia se enfrentan a la dificultad de facilitar a sus alumnos el acceso a la bibliografía recomendada de las asignaturas. Este problema se ha extendido a todas las universidades durante la pandemia de Covid-19. La solución más evidente consiste en dar acceso a esa bibliografía en formato digital. 
En el presente trabajo se analiza la bibliografía recomendada en el Grado en Información y Documentación online de la Universidad de León, el único que se imparte en esta modalidad en España, para conocer qué porcentaje de las monografías está disponible en formato digital, a través de licencias de préstamo en bibliotecas o en acceso abierto. Ante el bajo porcentaje obtenido, que no alcanza la tercera parte de las monografías y que resulta insuficiente, se reflexiona sobre las razones, se proponen medidas que pueden llevar a cabo las bibliotecas y el profesorado y se apunta la necesaria digitalización de las monografías.
Bibliometría y semántica en revistas de ciencias sociales del siglo XXI
Authors: Díaz Herrera Claudio , Moyano Díaz Emilio
Published: June 2023

En el entendido que un área de estudio se configura según la comunicación de sus medios de difusión científica en un contexto social, político y económico determinado, el artículo se propone analizar la semántica y estructura bibliométrica contenida en revistas científico-sociales misceláneas chilenas del siglo XXI. En términos metodológicos es un estudio bibliométrico y complementado con un análisis semántico cualitativo. Posee un diseño no experimental, descriptivo con alcances longitudinales. Se analizaron 1.554 publicaciones de tres revistas relevantes del sistema ciencia social chileno entre el año 2000 y 2019. Los resultados dan cuenta de a) una estructura de estos medios simbólicamente generalizados en estudio; y b) logran desentrañar la semántica científico social comunicada en estos medios. Se concluye que los medios de comunicación analizados son de escritura individual, masculina, de colaboración institucional principalmente chilena y argentina, con ascendente nivel de publicaciones, en idioma español, usando fuentes secundarias como documentación. En términos semánticos, los medios comunican una relevancia teórica y epistemológica, que con rigurosidad metodológica y ensayista construyen una reflexión político-social identitaria y situada. El trabajo posee un potencial innovador semántico y cualitativo aplicado a estudios bibliométricos de medios chilenos en un importante período de tiempo, con trabajo realizado sustancialmente a través de variables cuantitativas, complementando desde lo interpretativo en una construcción semántica que contribuye a configurar un ethos de un área de estudio desde sus de fuentes documentales.
Sector Specific Aid Inflow, Institutional Quality and Human Development in Selected Developing Countries
Authors: Gillani Ahmad Saad , Gillani Durdana Qaiser
Published: June 2023

Sector specific aid inflow has been considered significant for improved human development in developing economies. For this, we have analyzed how sector specific aid inflows and institutional quality affect human development by using panel data from 18 developing economies between 2002 and 2018. We have used a single equation linear model generalized method of moments (GMM) to examine the relationship between dependent and independent variables. The data has been taken from World Development Indicators, World Bank, and Organization for Economic Cooperation and Development. The result showed that aid and institutional quality were positively and significantly linked with the human development index. More aid was justified if stronger economic, political, and institutional governance could be secured in the receiving nations and the requirement for institutional improvements to make aid an influential instrument for human development in the concerned economies. The study suggests for more proper allocation of aid commitments among these countries for high growth and development. There should be a stable economic and political environment and high trade with other countries.
Mối liên quan của nồng độ HBV-RNA huyết tương tại thời điểm trước điều trị với đáp ứng virus sau điều trị ở bệnh nhân viêm gan virus B mạn tính
Authors: Ứng Nguyễn Đình
Published: June 2023

Mục tiêu: Xác định mối liên quan của nồng độ HBV-RNA huyết tương tại thời điểm trước điều trị đối với tình trạng đáp ứng virus sau 6 tháng điều trị tenofovir disoproxil fumarate (TDF). Đối tượng và phương pháp: 77 bệnh nhân viêm gan virus B mạn tính được thu thập máu ngoại vi tại thời điểm khi trước điều trị; sau 3 và 6 tháng điều trị. Phương pháp realtime RT-PCR được sử dụng để định lượng nồng độ HBV-RNA và HBV-DNA huyết tương. Phân tích dữ liệu bằng phần mềm Medcalc 20.019. Kết quả: Ở bệnh nhân HBeAg ban đầu dương tính (n = 34), giá trị tiên lượng của nồng độ HBV-RNA huyết tương trước điều trị đối với tình trạng đáp ứng virus sau 6 tháng ở mức khá tốt (AUC = 0,77; 95% CI: 0,59-0,89, p<0,05); điểm cắt tối ưu là 6,17 log copies/ml; độ nhạy đạt 94,12% và độ đặc hiệu đạt 70,59%. Bệnh nhân có HBeAg dương tính và nồng độ HBV-RNA ban đầu thấp hơn 6,17 log copies/ml có khả năng đạt tình trạng đáp ứng virus sau 6 tháng cao gấp 9,90 lần so với những người còn lại. Kết luận: Nồng độ HBV-RNA huyết tương thời điểm trước điều trị là một yếu tố dự báo đối với tình trạng đáp ứng virus sau 6 tháng điều trị ở những bệnh nhân có HBeAg dương tính, được điều trị bằng TDF.
Tìm hiểu mối liên quan giữa một số yếu tố lâm sàng và siêu âm tim nhĩ trái ở bệnh nhân bệnh thận mạn
Authors: Chiến Đỗ Văn
Published: June 2023

Mục tiêu: Tìm hiểu mối liên quan giữa một số yếu tố lâm sàng và siêu âm tim nhĩ trái ở bệnh nhân có bệnh thận mạn. Đối tượng và phương pháp: Nghiên cứu được thực hiện trên 150 đối tượng có bệnh thận mạn được điều trị nội trú tại Bệnh viện Bạch Mai trong thời gian từ tháng 4 đến tháng 10 năm 2022. Tất cả các bệnh nhân đều được thăm khám lâm sàng và siêu âm tim qua thành ngực để đánh giá kích thước và sức căng nhĩ trái. Kết quả: Mức lọc cầu thận (MLCT), hemoglobin có tương quan nghịch với đường kính nhĩ trái (LAD) (r = -0,51, p<0,001, r = -0,27, p=0,002. Tuổi (nam > 60 tuổi, nữ > 55 tuổi) có liên quan đến suy giảm sức căng trữ máu ở mặt cắt 4 buồng nhiều gấp 2,9 lần so với bệnh nhân có tuổi không nguy cơ tim mạch (OR = 2,9, 95% CI: 1,4-4,5). Tăng HA tâm thu có nguy cơ bị giãn nhĩ trái nhiều gấp 7,85 lần so với bệnh nhân không có THA tâm thu (OR = 7,85, 95% CI: 3,89-16,79, p<0,05). Tăng HA tâm trương có nguy cơ bị giãn nhĩ trái nhiều gấp 2,58 lần so với bệnh nhân không có THA tâm trương (OR = 2,58; 95%CI: 1,67-6,20, p<0,05). Đái tháo đường có nguy cơ giảm sức căng trữ máu ở mặt cắt 4 buồng nhiều gấp 3,59 lần so với bệnh nhân có tuổi không nguy cơ tim mạch (OR = 3,59; 95%CI: 1,8-6,2). Kết luận: Tuổi (nam > 60, nữ > 55) ở bệnh nhân có bệnh đái tháo đường, tăng huyết áp là những yếu tố lâm sàng có liên quan đến kích thước và sức căng nhĩ trái ở bệnh nhân bệnh thận mạn.
Tình trạng rối loạn cơ xương khớp trên người bệnh hemophilia ở miền Bắc, Việt Nam
Authors: Hằng Đặng Thị Thúy
Published: June 2023

Mục tiêu: Mô tả đặc điểm rối loạn cơ xương khớp của người bệnh hemophilia ở miền Bắc bằng phiếu chấm điểm tình trạng khớp trong bệnh hemophilia phiên bản 2.1 (Hemophilia Joint Health Score - HJHS). Đối tượng và phương pháp: Thiết kế nghiên cứu là mô tả cắt ngang trên người bệnh hemophilia tại 4 tỉnh/thành phố từ tháng 12/2021 đến tháng 3/2022. Kết quả: Tổng số 82 người bệnh đã được lượng giá (tuổi trung bình là 27 ± 11,97), trong đó có 61 người bệnh hemophilia A và 21 người bệnh hemophilia B. Điểm HJHS toàn bộ: 24 (9-45); điểm khớp gối trái, phải lần lượt là 6 (1-10) và 5 (2-9). Các rối loạn ở hệ cơ xương khớp: Giới hạn tầm vận động, teo cơ, suy giảm sức mạnh cơ… đã được ghi nhận ở các khớp. Kết luận: Người bệnh hemophilia ở miền Bắc có điểm HJHS tương đối cao. Tình trạng rối loạn cơ xương khớp trên người bệnh hemophilia diễn ra ở hầu hết các khớp bản lề. Chức năng vận động của khớp bị hạn chế, dáng đi có sai lệch nhiều, khó khăn khi di chuyển.
Cập nhật chẩn đoán và điều trị bệnh Crohn có rò hậu môn
Authors: Hoàng Bùi Hữu
Published: June 2023

Rò hậu môn là biến chứng thường gặp và có thể gây ra nhiều kết cục xấu cho bệnh nhân bệnh Crohn. Chụp cộng hưởng từ vùng chậu hay siêu âm qua ngã hậu môn là các xét nghiệm được khuyến cáo thực hiện để đánh giá giải phẫu đường rò. Thăm khám dưới gây mê cũng có vai trò quan trọng trong đánh giá rò hậu môn cũng như tiến hành các can thiệp tức thì như dẫn lưu áp xe hay cột dây thun. Kết hợp phương pháp này với chụp cộng hưởng từ hay siêu âm qua ngã hậu môn giúp gia tăng độ chính xác trong đánh giá trước điều trị. Chiến lược điều trị sẽ tùy thuộc vào loại đường rò (đơn giản hay phức tạp) và tình trạng viêm trực tràng đi kèm. Điều trị xuống thang thường được chọn lựa, nhất là đối với các trường hợp rò phức tạp hay có viêm trực tràng. Dẫn lưu áp xe và/hoặc cột dây thun là các điều trị đầu tay trước khi khởi động thuốc ức chế miễn dịch. Kháng TNF là chọn lựa hàng đầu trong điều trị nội khoa và thường dùng kèm với thuốc điều hòa miễn dịch và kháng sinh. Các can thiệp ngoại khoa đóng đường rò chỉ nên thực hiện khi viêm trực tràng đã cải thiện. Phẫu thuật cắt trực tràng và hậu môn nhân tạo trên dòng là các lựa chọn sau cùng, được chỉ định cho những trường hợp rò phức tạp, không đáp ứng với các điều trị kể trên.
Solid state synthesis, characterization and biological evaluation of silver doped nanosized metal oxides
Authors: Tanuja G. , Ganiger Sangappa K , Shashidhar Shashidhar , Preeti R.K. , Patil Somanath Reddy , Lagashetty Arunkumar
Published: June 2023

Nanomaterials have attracted a great deal of attention from the scientific community due to their unique properties and applications. The small size metal oxides have opened up the door for intensive research to utilize their properties for biomedical applications. Silver nanoparticle (AgNPs) and metal oxide nanomaterials like MgO, ZnO, NiO and its silver doped nanocomposites (Ag-MgO, Ag-ZnO, Ag-NiO) have been prepared using solid state combustion method using polyvinyl alcohol (PVA) as a fuel. The structure of as prepared oxides and its silver doped nanocomposites were characterized using X-ray diffraction (XRD) tool and morphology by Scanning Electron Micrograph (SEM) tool as well as Transmission electron micrograph tool respectively. Presence of the metals in the oxides and its Ag composite was confirmed by the EDX pattern. Bonding nature in the composite is well studied by the Fourier transform infrared (FT-IR) tool. Antibacterial activity studies of the nanocomposites are carried out against various bacteria.
A convenient synthesis, characterization and biological evaluation of novel schiff base heterocycles as potential antimicrobial, antitubercular agents and their structural activity relationship
Authors: Maruthesh H. , Katagi Manjunatha S. , Nandeshwarappa B.P.
Published: June 2023

A series of (E)-1-methyl-3-((substituted phenylimino)methyl)quinolin-2(1H)-one schiff bases (3a-j) bearing quinoline moiety synthesized successfully in ethanol by condensation of starting material 1-methyl-2-oxo-1,2-dihydroquinoline-3-carbaldehyde (1) with various substituted anilines (2a-j). The structure of the newly synthesized compounds was confirmed by proton (1H) and carbon (13C) nuclear magnetic resonance spectroscopy, Fourier transformation infrared (FT-IR), Mass spectroscopic study and elemental analysis. The in-vitro antimicrobial activity of the synthesized compounds was undertaken by agar well diffusion method against gram positive bacteria (Bacillus licheniformis and Bacillus cereus) gram negative bacteria (Escherichia coli and Acetobactor sp.) and antifungal activity against (Aspergillus Flavus and Pichnanomala). Further the compounds which shows good activity (3b, 3c, 3d, 3f, 3g and 3j) are screened for in-vitro antitubercular activity by Micro-plate alamar blue assay (MABA) method against mycobacterium tuberculosis H37Rv strain provided important information about activity against these strains. The structure activities of the synthesized compounds were also discussed. Compounds 3a, 3c, 3d, 3f and 3g show good argument with the different substituent attached to the phenyl ring.
In silico molecular docking study and Protective effect of Piper attenuatum on aspirin induced gastric ulcer in rats
Authors: Soni Gaurav Kumar , Sharma Shikha , Dangi Neha
Published: June 2023

Steroid and painkiller abuse induced peptic ulcer disease, which causes abdominal pain, fullness, heartburn, and nausea. Medicinal plants have treated ulcers for centuries. We used Piper attenuatum ethanolic plant extracts for aspirin to induce ulcers in Wistar rats to test the leaf ethanolic extract's antiulcer properties. The control group is normal saline, the standard group is ranitidine (20 mg/kg), and the extract-treated groups are 100 mg/kg and 200 mg/kg ethanolic plant extracts. Ulcer Score, gastric juice volume, free and total acidity, ulcer index, ulcer protection, and pH were measured. The ulcer score was determined via rat stomach biopsies. Plant ethanolic extracts are gastroprotective. Only pH increased compared to the control group. Piper attenuatum ethanolic extract is the most gastroprotective at 200 mg/kg. Extracts were phytochemically and analytically assessed. Phytochemical screening demonstrates that plant extracts contain alkaloids, amides, glucose, proteins, glycosides, steroids, flavonoids, etc. This research suggests that phytoconstituents may have anti-ulcer potential, although structural elucidation of bioactive chemicals is needed. Molecular docking showed better binding affinity versus the 3D structure of pig gastric H+/K+ ATPase isoforms phytoconstituents Cepharadione A, Cepharadione B, Guineensine, Norcepharadione B, and Piperlonguminine. With these significant results, it may be a drug in the future.
Some oxoimidazolidine and cyanoguanidine compounds: Toxicological efficacy and structure-activity relationships studies
Authors: Abdel-Raheem Shaban A. A. , Drar Ali M. , Hussein Bahgat R. M. , Moustafa Amr H.
Published: June 2023

This manuscript reports the preparation and toxicological efficacy testing of nine oxoimidazolidine and cyanoguanidine compounds (3a, 3b, 3c, 3d, 3e, 3f, 3g 4a, and 4b) against cowpea aphid, Aphis craccivora Koch. Bioefficacy data revealed that the tested compounds exhibited a range of toxicological activities against these insects, with compound 3b being the most toxic and compound 4a being the least effective. The LC50 value of compound 3b was 1.72 ppm for adults and 0.02 ppm against nymphs of the cowpea aphid, while the LC50 value of compound 4a was 72.51 ppm for adults and 18.02 ppm against nymphs. The manuscript also presents the structure-activity relationships of these compounds. These results provide valuable insights into the development of effective pest control agents for the management of such insects.
Synthesis and antioxidant activity evaluation of some new 4-thiomethyl functionalised 1,3-thiazoles
Authors: Danyliuk Ivanna , Kovalenko Nataliia , Tolmachova Valentyna , Kovtun Olena , Saliyeva Lesya , Slyvka Nataliia , Holota Serhii , Kutrov Gennady , Tsapko Magdalina , Vovk Mykhailo
Published: June 2023

The 4-bromomethyl-substituted thiazolium salts and corresponding thiazoles obtained through the condensation of 1,3-dibromoacetone with thioamide derivatives were utilised as efficient alkylating reagents for a series of thiophenols and heterylthiols. As a result, a small library of 4-thiomethyl-functionalised 1,3-thiazoles was synthesised in high yields, and their structures were characterised by 1H, 13C NMR, LC-MS and IR spectra. Antioxidant activity of obtained compounds was studied in vitro using the DPPH test. The synthesised compounds showed high absorption level of DPPH radicals in the 70-98% range. For the most active derivatives 7e,m,p,t IC50 values were determined, which were in the range 191-417 µM (for ascorbic acid (reference) IC50 value was 29 µM). Obtained radical scavenging activity screening data suggest in-depth study of the antioxidant potential for these types of heterocyclic compounds.
II. MEŞRUTİYET PARLAMENTOSUNDA KADINLARA SEÇMEN OLMA HAKKININ TANINMASINA YÖNELİK YAPILAN TARTIŞMALAR
Authors: ATAM Şenay , ULUDAĞ Mehmet Şakir
Published: June 2023

Osmanlı Devleti yapısı itibarıyla Osmanlı hanedanından birinin devletin başına geçtiği mutlak-monarşik sistemle yönetilmektedir. Padişahın danışma meclisi Divan-ı Hümayunda yasama, yürütme ve üst mahkeme olarak yargı faaliyetleri yürütülse de son karar padişaha aittir. Bir yandan parlamenter sistemin İngiltere’de uygulanmaya başlanması, diğer yandan Fransız İhtilali ile Avrupa’da sosyal ve siyasal değişimin başlamasından sonra Osmanlı Devleti de bu değişim rüzgârından etkilenmiştir. Osmanlı Devleti’nde ilk olarak Jön Türk hareketi ile yaşanan halkın karar mekanizmasına dâhil edilmesi talebi öncelikle 1876 yılında I. Meşrutiyet’in ilanı ile neticeye ulaşmıştır. II. Abdülhamit o dönemde içerde ve dışarıda yaşanan olaylardan etkilenerek geçici olarak meşruti yönetimi askıya alsa da yeniden parlamenter sisteme geçiş bu sefer İttihat ve Terakki’nin girişimleri ile 1908 yılında II. Meşrutiyet’in ilanından sonra mümkün olabilmiştir. Fakat halkın seçimi ile meydana gelecek olan Mebusan Meclisi üye seçimine her iki dönemde de kadınlar dâhil edilmemiştir. Meclise üye seçiminde seçmenler ve seçilecek olanlar erkeklerden olacaktır. Seçim kanununa göre her 50.000 erkek nüfus bir mebus seçebilecek ve seçim iki aşamalı yapılacaktır. Bırakın milletvekili olmayı kadınlar kendilerini temsil edecek kişileri dahi seçme hakkına sahip değillerdir. Bu çalışmada Osmanlı Mebusan Meclisi oturumlarında kadınların seçimlere dâhil edilebilmesine yönelik konunun gündeme gelmesi ve tartışılmasına dair meclis tutanakları ve İttihat ve Terakki Fırkası’nın yayın organı olarak adlandırılan Tanin Gazetesi incelenerek kadına seçme hatta seçilme hakkının verilmesi fikrinin nasıl karşılandığı ortaya konulmuştur.
The Safety and Efficacy of Endoscopic Lacrimal Duct Probing in Neonates with Acute Dacryocystitis
Authors:   Hefei Bright Eye Hospital, Hefei, China, Junjie Zhuan Sun
Published: June 2023

Objective: To observe the safety and efficacy of endoscopic-assisted lacrimal duct probing in neonates with acute dacryocystitis. Methods: The prospective treatment of 148 eyes of 103 cases of neonatal acute dacryocystitis was studied. In the observation group, 58 cases (76 eyes) underwent endoscopic exploration of lacrimal passage under topical anesthesia.
Necrotizing Fasciitis of Breast: A Rare but Fatal Entity
Authors:   Department of Internal Medicine and Rheumatology, Olive Health Care, Thrissur, India, Jalal Muhammed Jasim Abdul
Published: June 2023

Necrotising fasciitis is a rapidly developing, fatal bacterial infection of deep subcutaneous tissues. It may occur at any site in the body; breast being a rare site. We describe a case of necrotizing fasciitis in the breast that was diagnosed on the basis of ultrasound and CT scan findings.
Risk factors and therapeutic options for postoperative intra-abdominal septic complication in Crohn’s disease
Authors:   Luigi Sacco University Hospital, Micalef Andrea
Published: June 2023

Background: Approximately 70% of patients suffering from Crohns disease require surgery in their lifetime. The postoperative course
SOCIO-ECONOMIC PROFILE OF LARGE CITIES OF KAZAKHSTAN
Authors: Kangalakova D. M. , Satpayeva Z. T. , Ilyas A.
Published: June 2023

The purpose of the study is to analyze the current state of socio–economic development of large cities of Kazakhstan, identify problems and develop proposals for their development.

Methodology. In the course of the work, statistical and comparative economic analysis, methods of generalization and systematization were used. To identify the strengths and weaknesses, threats and advantages of the development of large cities, a SWOT analysis was conducted. With the help of the logical method, potential directions for the development of large cities of Kazakhstan were identified.

Originality / value of the research. The study analyzed the socio-economic development of large cities, identified the strengths and weaknesses of their development, as well as identified threats and opportunities for the development of large cities of the Republic of Kazakhstan. Based on the analysis, the directions of development of large cities are proposed.

Findings. During the analysis of the socio-economic development of large cities, it was revealed that in all large cities there is a certain factor determining its development. For example, in the cities of Aktau and Atyrau, a high income of the population is fixed, since the cities specialize in the extraction and processing of hydrocarbon raw materials, etc. The problems hindering the development of large cities include a high increase in the number of unemployed, a shortage of housing stock, the deterioration of utility networks, an increase in the number of citizens in need of social support, and a high level of atmospheric pollution. The directions of development of large cities of the Republic of Kazakhstan are proposed.
FORMATION OF WHOLESALE DISTRIBUTION CENTERS IN THE FOOD SUPPLY SYSTEM OF REGIONS OF KAZAKHSTAN
Authors: Momynkulova Sh.
Published: June 2023

This article explores and provides an empirical assessment of the state of distribution of food products from direct producers to end consumers in terms of an effective system of commodity supply to the regions of Kazakhstan based on a review of specialized literature and information.

The purpose of the research is to give recommendations and proposals for the creation of wholesale distribution centers that will promote the efficient and optimal movement of agricultural products directly from producers to consumers.

Research methodology. We used heuristic research methods based on the method of expert assessments, interview review, and, also, used situational and reflexive approaches to analyze available and objective information.

The originality of the research. We did a general analysis of the distribution of food products based on a review of specialized literature revealed many problems in this area. We have studied foreign experience and give recommendations and proposals for the creation of effective wholesale distribution centers in major cities of Kazakhstan.

Research results. According to the research results, we simplified scheme of the food supply chain from agricultural producers to consumers is proposed, excluding unnecessary intermediaries. The problems and prospects for the development of wholesale distribution centers are identified and specified. The main priorities of the development of the wholesale distribution centers are highlighted.
RESEARCH IN ECO-TOURISM IN KAZAKHSTAN AS A SUCCESSFUL MECHANISM IN THE DEVELOPMENT OF ENVIRONMENTAL TOURISM MANAGEMENT
Authors: Pazylkhaiyr B. M. , Assipova Zh. M. , Aktymbayeva A. S.
Published: June 2023

The purpose of this study is to determine the current level of ecotourism research in tourism environmental management of Kazakhstan and to perform a comparison assessment in order to gain a better understanding through critical analysis and the identification of gaps for future studies.

Methodology. Analysis, comparison, and literature review have been used as the methods of this work.

The originality / value of the study is an accurate analysis of the present situation of ecotourism research in Kazakhstan and Bhutan. The Bhutanese example of ecotourism research could contribute for the further development of tourism environmental management in Kazakhstan. 

Findings. The authors found a few main problems of ecotourism research, including having lack of comprehensive data and information and problems with regulatory legal acts and documents in Kazakhstan. Therefore, right ecotourism study can facilitate to the development of the tourism environmental management in Kazakhstan.

Through analyzing the Bhutanese practice of ecotourism research, the authors found a gap in Kazakhstan tourism environmental management where further research should be focused. Consequently, the authors gave a few recommendations on the further development of ecotourism research in Kazakhstan, as working with closely with foreign experienced researchers, improving the protected areas websites, establishing a trust fund with other countries, improving government documents on tourism environmental management, publishing more reports in English, and providing more grants and scholarships.
Dragonfly: Flights of Exploration Across Saturn's Moon Titan, an Organic Ocean World
Authors: Turtle Elizabeth (Zibi)
Published: June 2023

Saturn's largest moon, Titan, is an ocean world with a dense atmosphere, abundant complex organic material on its icy surface, and a liquid-water ocean within its interior. The Cassini-Huygens mission revealed surprisingly Earth-like geological processes and opportunities for organic material to have mixed with liquid water on Titan's surface in the past. These attributes make Titan a singular destination to seek answers to fundamental astrobiological questions about the habitability of other worlds in our solar system and prebiotic chemical processes like those that led to the development of life here on Earth.

In this talk, I will present an overview of Titan and the exploration planned with NASA's upcoming Dragonfly New Frontiers mission. Dragonfly is a rotorcraft lander designed to perform wide-ranging in situ investigation of the chemistry and habitability of this carbon-rich extraterrestrial environment. Taking advantage of Titan's dense atmosphere and low gravity, Dragonfly will fly from place to place, exploring diverse geological settings to sample and measure detailed compositions of surface materials and observe Titan's geology and meteorology. During its  3.3-year mission, Dragonfly will make multidisciplinary science measurements at a few dozen landing sites to characterize Titan's habitability and determine how far organic chemistry has progressed in environments that have provided key ingredients for life.