bluuebunny/crossref_metadata_2025 huggingface dataset:
Non-Financial Reporting Regarding Natural Environment in Public Companies in the Energy, Fuel and Gas Sector in 2019
Authors: Dembowska Katarzyna
Published: March 2022

The article's objective is a presentation of the non-financial reporting practice in the scope of issues regarding the natural environment in public companies based on the example of the energy, fuel and gas sectors. The study covers WIG20, WIG30 and mWIG40 companies listed on the Warsaw Stock Exchange in 2019. The research method applied in the article is based on a case study. The article starts with the theoretical part regarding the disclosure of non-financial information. The second part presents non-financial reporting with special consideration given to the natural environment, based on public companies operating in the energy, fuel and gas sector.
Modern Biomarkers for Assessing the Metabolic Status of Zinc in Humans and their Laboratory and Diagnostic Significance (Review)
Authors: Гармаза Ю.М. , Слобожанина Е.И.
Published: March 2022

Цинк является одним из жизненно важных элементов организма человека. Пребывая в нем в виде двухвалентного иона, он в физиологических условиях не проявляет редокс-активности, участвуя вместе с тем в осуществлении разнообразных физиологических функций путем характерного для этого микроэлемента влияния на разнообразные биологические процессы. Например, цинк может быть представлен в качестве структурного, каталитического, внеклеточного или внутриклеточного сигнального компонента.К настоящему времени описаны многие симптомы, вызванные дефицитом цинка в организме, однако проблема лабораторной диагностики этого состояния все еще окончательно не решена. В данном обзоре представлена информация о современных биомаркерах (уровень содержания цинка, металлотионеинов и цинк-зависимых ферментов в плазме и клетках крови, моче) оценки метаболического статуса цинка в организме человека и их лабораторно-диагностическая значимость. Также уделено внимание методам оценки уровня содержания цинка в биологических системах.

Zinc is one of the essential elements for humans, which exists as a bivalent cation and does not exhibit redox activity under physiological conditions. Exactly this feature explains its various physiological functions in various biological processes. For example, zinc can be present as a structural, catalytic extracellular or intracellular signaling component. Therefore, it is not surprising that zinc deficiency is a significant global health problem. Today, many symptoms caused by zinc deficiency have been described; however, laboratory diagnostics of this condition is a problemthat has not been fully resolved. This review provides information about the modern biomarkers (serum, blood cells, urine zinc levels, level of metallothioneins, as well as zinc-dependent enzymes, etc.) for assessing the metabolic status of zinc in humans and its laboratory diagnostic significance. The methods for assessing the zinc level in biological systems are also described in general.
Laboratory Monitoring of the Thyroid Status of Patients while Taking Amiodarone
Authors: Кузьменко А.Т. , Батуревич Л.В.
Published: March 2022

В связи с широким использованием в практике лечения разных видов аритмий амиодарона, высоким содержанием в препарате йода и липофильностью лекарственного средства необходимо помнить о связанных с его применением возможных нежелательных эффектах. Употребление амиодарона может создать ряд побочных эффектов, одним из которых является нарушение функциональной активности щитовидной железы, сопровождаемое изменениями характеризующих ее состояние показателей лабораторных тестов.Различают индуцированный амиодароном гипотиреоз, тиреотоксикоз, а также смешанные (недифференцированные) формы патологии.Индуцированный амиодароном гипотиреоз может развиваться у пациентов с нормальной функцией щитовидной железы и отсутствием аутоиммунной реакции, но чаще всего он выявляется у пациентов со скрытым хроническим аутоиммунным тиреоидитом, преобладает у женщин, а также в йодонасыщенных областях.В статье рассматриваются особенности диагностики амиодарон-индуцированных нарушений функции щитовидной железы, а также представлены алгоритмы обследования пациента до начала и во время терапии амиодароном.Вместе с тем приведенная в материалах статьи информация отражает проявление лекарственным средством метаболической и, возможно, химической интерференции, способной повлиять на показатели лабораторных тестов, отражающих состояние функции щитовидной железы.

Due to the widespread use of amiodorone in the treatment of various types of arrhythmias, the high content of iodine in the preparation and the lipophilicity of the drug, it is necessary to remember about the possible undesirable effects associated with its use. The use of amiodarone can create a number of side effects, one of which is a violation of the functional activity of the thyroid gland, accompanied by changes in the parameters of laboratory tests characterizing its state.There are hypothyroidism induced by amiodarone, thyrotoxicosis, and mixed (undifferentiated) forms of pathology.Amiodarone-induced hypothyroidism can develop in patients with normal thyroid function and lack of autoimmune response, but most often, it is detected in patients with latent chronic autoimmune thyroiditis, which prevails in women, and also at the iodine-saturated areas.In the article, there are discussed the features of diagnostics of amiodarone-induced thyroid dysfunction; it also presents the algorithms for examining patients before and during the amiodarone therapy.At the same time, the information given in the materials of the article reflects the manifestation of metabolic and, possibly, chemical interference of the drug, which can affect the indicators of laboratory tests reflecting the state of the thyroid gland function.
Human Defense Mechanisms Against Viruses Causing Acute Respiratory Infections
Authors: Цыганков А.М. , Янченко В.В. , Лятос И.А.
Published: March 2022

Болезни человека, вызываемые вирусами, – актуальная тема современной иммунологии и инфектологии. Понимание защитных механизмов человека против вирусов и путей преодоления вирусами такой защиты является ключевым в диагностике, профилактике и лечении вирусных инфекций. Для военной медицины Вооруженных Сил Республики Беларусь (ВС РБ) особенно актуальны вопросы, связанные с развитием острых респираторных инфекций среди военнослужащих. Мы проанализировали публикации в научных журналах биомедицинской направленности с целью описать механизмы взаимодействия вирус – человек, способы защиты человека, охарактеризовать роль системы иммунитета при острых респираторных вирусных инфекциях (ОРВИ), а также механизмы обхода и уклонения вирусов, преодоления ими защитных барьеров. Благодаря многочисленным научным исследованиям стало возможным более глубокое понимание взаимодействия организма человека и вирусов, вызывающих ОРВИ, что отражается в современных методах профилактики, диагностики и лечения. Особенно актуальна тема дальнейшего изучения нового коронавируса (SARS-CoV-2) по причинам недостаточной изученности влияния на воинские коллективы ВС РБ и недостаточных данных для эффективной реализации профилактических и лечебных мероприятий против COVID-19 в воинских коллективах.

Human diseases caused by viruses are a hot topic in modern immunology and infectious diseases. Understanding the human defense mechanisms against viruses and the ways to overcome such defense by viruses is key in the diagnosis, prevention and treatment of viral infections. For the military medicine of the Armed Forces of the Republic of Belarus, the issues related to the development of acute respiratory infections among military personnel are particularly relevant. Publications in biomedical scientific journals were analyzed in order to describe the mechanisms of virus-human interaction, methods of human protection, especially to characterize the role of the immune system in acute respiratory viral infections, as well as mechanisms of virus evasion and evasion, overcoming the protective barriers. Numerous scientific studies have made it possible to better understand theinteraction between the human body and the viruses that cause acute respiratory viral infections, which is reflected in modern methods of prevention, diagnosis and treatment. The topic of further studies of a new coronavirus (SARS-CoV-2) is especially urgent for the reasons of insufficiently studied impact on military teams of the Armed Forces and insufficient data for effective implementation of preventive and therapeutic measures against COVID-19 in military teams.
Clinical Characteristics, Diagnosis and Treatment of Coronovirus Infection in Children
Authors: Романова О.Н. , Коломиец Н.Д. , Ключарева А.А. , Сергиенко Е.Н. , Савицкий Д.В. , Соколова М.В. , Оскирко А.Н. , Матуш Л.И. , Ханенко О.Н. , Манкевич Р.Н. , Лисицкая Т.И. , Раевнев А.Е. , Тонко О.В. , Крастелева И.М. , Ткаченко А.К. , Артемчик Т.А. , Батян Г.М.
Published: March 2022

Коронавирусы являются важными патогенами человека и животных. За прошедший год, когда мир столкнулся с новым заболеванием COVID-19, представления об эпидемиологии, клиническом проявлении, лечении и профилактике заболевания существенно расширились, а в некоторых областях даже изменились. Совершенно очевидно, что по мере накопления знаний в понимании нового заболевания произойдет немало изменений. Все мы не теряем надежды на разработку надежного лекарственного средства и успехи вакцинации. В этой работе мы обобщили данные об особенностях COVID-19 у детей, а именно распространении, клиническом течении, клинико-лабораторной диагностике и рекомендуемых сегодня принципах лечения и профилактики. В работу вошли материалы наших собственных наблюдений 1379 детей с COVID-19, находившихся на стационарном лечении в учреждении «Городская детская инфекционная клиническая больница» г. Минска (ГДИКБ) с марта по ноябрь 2020 г. Из них с подтвержденной инфекцией бессимптомное течение заболевания имели 17,6%, легкое – 40,2%, средней степени тяжести – 41,1% и тяжелое – 1,1%.

Coronaviruses are important pathogens of humans and animals. Over the past year, when the world faced with the new COVID-19 disease, the understanding of the epidemiology, clinical manifestation, treatment and prevention of the disease has significantly expanded and even changed in some areas. It is quite obvious that many changes will occur as knowledge accumulates in the understanding of a new disease. All of us do not lose hope for the development of a reliable drug and the success of vaccination. In this work, we summarized the data on the features of COVID-19 in children, namely, the spread, clinical course, clinical and laboratory diagnosis and theprinciples of treatment and prevention recommended for today. The work included the materials of our own observations of 1379 children with COVID-19 who were on inpatient treatment at the "City Children’s Infectious Clinical Hospital" in Minsk (CCICH) from March to November 2020 Of these, 17.6% had asymptomatic course of the disease with confirmed infection, 40.2% – mild course, 41.1% – moderate severity and 1.1% – severe course.
The Role of the Human Microbiomein the Development of Pain Syndromes
Authors: Усова Н.Н. , Лихачев С.А.
Published: March 2022

В статье проведен аналитический обзор литературы по теме влияния микробиоты человека на возникновение болевых синдромов различной этиологии и модальности. Исследования взаимоотношений по оси «микробиом – кишечник – головной мозг» показали их двунаправленный характер. Микроорганизмы кишечника регулируют обмен нейромедиаторов, работу иммунной системы, отношения по гипоталамо-гипофизарно-адреналовой оси. Основными путями, обеспечивающими взаимовлияния между микробиотой и организмом, являются волокна и образования вегетативной нервной системы, неокортекс. Влияние микробиоты на возникновение многих неврологических заболеваний и формирование болевого синдрома не вызывает сомнений и открывает перспективы разработки эффективных способов лечения. Приведены новые терапевтические стратегии лечения хронического болевого синдрома, основанные на современных знаниях о микробном разнообразии организма человека.

The article presents an analytical review of the literature on the influence of the human microbiota on the occurrence of pain syndromes of various etiologies and modalities. Studies of the relationships along the microbiome – gut – brain axis have shown their bidirectional nature. Intestinal microorganisms regulate the exchange of neurotransmitters, the work of the immune system, and the relationship along the hypothalamic-pituitary-adrenal axis. The main pathways that provide interaction between the microbiota and the body are the fibers and formations of the autonomic nervous system, the neocortex. The influence of the microbiota on the occurrence of many neurological diseases and the formation of pain syndrome is beyond doubt and opens up prospects for the development of effective treatment methods. New therapeutic strategies for the treatment of chronic pain syndrome, based on modern knowledge about the microbial diversity of the human body, are presented.
Clinical Case of Forestier Disease, which Simulated Acute Stroke
Authors: Рушкевич Ю.Н. , Переверзева О.В. , Шабалина Ю.С. , Малюкова С.А. , Правосуд М.В.
Published: March 2022

Болезнь Форестье, или анкилозирующий диффузный скелетный гиперостоз, – хроническое, медленно прогрессирующее невоспалительное заболевание опорно-двигательного аппарата, в основе патогенеза которого лежит избыточная оссификация связок и сухожилий, приводящая к анкилозированию. Распространенность болезни Форестье среди пациентов старше 70 лет достаточно высока и составляет среди мужчин 10%, среди женщин – 6,7%. Болезнь Форестье характеризуется неспецифичностью клинической картины и жалоб пациентов, вследствие чего зачастую возникают затруднения при постановке диагноза. При выраженной оссификации передней и задней продольных связок позвоночника могут возникать сдавление пищевода, гортани, трахеи, компрессия спинного мозга, сопровождающаяся возникновением миелопатии, парезов, нарушения функций тазовых органов. Приведенный нами клинический случай болезни Форестье позволит акцентировать внимание врачей-специалистов на данной нозологической форме, избежать ошибок в установлении диагноза и избрать наиболее оптимальную тактику лечения.

Forestier’s disease, or diffuse idiopathic skeletal hyperostosis, is a chronic, slowly progressive, non-inflammatory disease of the musculoskeletal system, the pathogenesis of which is based on excessive ossification of ligaments and tendons, leading to ankylosis. The prevalence of Forestier’s disease among patients over 70 years old is quite high – 10% among men and 6.7% among women. Forestier’s disease has nonspecific clinical manifestations. In the case of pronounced ossification of the anterior and posterior longitudinal ligaments and the associated compression of the spinal cord, the clinical manifestations of the disease may include myelopathy, paresis, and dysfunction of the pelvic organs. The description of the case of Forestier’s disease in this article can focus the attention of medical specialists and improve their knowledge about this nosological form to avoid mistakes in diagnostics and choose the most optimal treatment tactics.
Features of Individual Hygiene in Patients Undergoing Orthodontic Treatment
Authors: Рубникович С.П. , Денисова Ю.Л. , Кузьменко Е.В. , Андреева В.А. , Тимчук Я.И. , Валеева З.Р.
Published: March 2022

Применение съемных и несъемных ортодонтических аппаратов у пациентов препятствует нормальному протеканию процессов самоочищения в полости рта, затрудняет проведение гигиенических мероприятий, особенно на начальных этапах лечения. Конструктивные элементы аппаратуры являются ретенционными пунктами для скопления мягкого зубного налета и остатков пищи. В результате повышается численность и активность микроорганизмов и значительно увеличивается риск возникновения кариеса и болезней периодонта. Поэтому вопросам поддержания хорошей гигиены полости рта, профилактики и лечения воспалительных заболеваний периодонта у пациентов, которым проводится ортодонтическое лечение, уделяется первоочередное внимание.

The use of removable and fixed orthodontic appliances in patients interferes normal self-cleaning processes in the oral cavity, and makes it difficult to carry out hygienic activities, especially during initial stages of treatment. Structural elements of appliances are retention items for the accumulation of soft plaque and food remains. As a result, the population and activity of microorganisms as well as the risk of caries and periodontal diseases appearance increases significantly. Therefore, the issues of maintaining good oral hygiene, prevention, and treatment of inflammatory periodontal diseases in patients undergoing orthodontic treatment are given priority attention.
Significance of Immunophenotypic and Molecular Genetic Markers in Prediction of Myelodysplastic Syndromes
Authors: Трубкина А.С. , Искров И.А. , Смольникова В.В. , Лебедева Т.В. , Лендина И.Ю.
Published: March 2022

В настоящее время нет универсальной прогностической шкалы, которая включала бы в себя все значимые для МДС параметры, и в этой связи при принятии решения о выборе тактики терапии необходимо оценивать прогноз сразу по нескольким шкалам (IPSS, IPSS-R, WPSS). Генетические нарушения, приводящие к образованию опухолевого клона, способствуют формированию аберрантного иммунофенотипа, отличающегося от антигенного профиля нормальных клеток.

Currently, there is no universal prognostic scale that includes all parameters significant for MDS. In this regard, when deciding on the choice of therapy tactics, it is necessary to evaluate the prognosis on several scales at once (IPSS, IPSS-R, WPSS).Genetic disorders that lead to the formation of a tumor clone contribute to the formation of an aberrant immunophenotype different from the antigenic profile of normal cells.
دور التشريعات التعاونية في الحد من العمالة غير المنظمة
Authors: ابراهيم محمد عبد الرحمن
Published: March 2022

نبحث في هذه الدراسة عن الدور الذي يمكن ان  تحققه التشريعات التعاونية في الحد  من  العمالة غير المنظمة، فتعد التعاونيات نافذة الاقتصاد الاجتماعي والتي تلعب دورا رئيسيا في تكملة الاسواق التقليدية والعمل الحكومي، لتعانق بذلك العاملين في الاقتصاد غير النظامي بكونه قارب النجاة للفئات المهمشة والمستبعدة، وهنا تأتي التعاونيات لتنظم القطاع الاقتصادي غير المنظم باعتباره احد الخيارات المتاحة للتنظيم، بقيام التعاونيات في تقديم الخدمات لا فرادها من ذلك الحصول على الموارد الطبيعية ، كما انها تيسر مشاركة افرادها صناعة القرار ليسهم في بناء مهارات صغار العاملين من خلال دعم قدرتهم على الابتكار ، وكسب ثقة المؤسسات المالية المانحة ، وفي النهاية التأثير على عملية صناعة القرار السياسي والتي لا تكون من الاخلال اطار استراتيجي يقوم من خلال تشريعات وطنية موائمة للتحديات المعاصرة، مع دعمها ماليا، وفي النهاية الاخذ بالعملية الديمقراطية من خلال التمثيل والحوار الاجتماعي باعتبارها هي الادوات الفاعلة للاعتراف بالتعاونيات العمالية غير المنظمة.
Aseguramiento de la calidad educativa universitaria en Iberoamérica: tendencias, ausencias y desafíos
Authors: Medina-Manrique Roberto , Carcausto Calla Wilfredo Humberto , Guzmán Shigetomi Evelin Elena
Published: March 2022

El aseguramiento de la calidad de la educación superior a nivel global es un proceso vital para lograr una cultura de mejora continua, en beneficio de la sociedad. Se busca proporcionar una visión sistemática de las tendencias y ausencias en el proceso de aseguramiento de calidad educativa universitaria de Iberoamérica, utilizando las dimensiones de calidad, según artículos científicos en revistas indizadas en dos bases de datos: Scopus y Scielo; entre 2012 y julio de 2021. Se consideran como criterios: el año y país de publicación, las tendencias y ausencias en cada dimensión de calidad, y los desafíos propuestos. De los 85 artículos la mayor cantidad corresponde a España y Chile; la tendencia predominante es investigar sobre la dimensión de calidad del marco del aseguramiento interno y externo, y la principal ausencia es de artículos sobre la dimensión calidad en instalaciones, recursos académicos y soporte; con sólo 1% (n=1). Los desafíos en aseguramiento de la calidad son variados por cada dimensión, siendo algunos la educación online o virtual, que surge en 2013 pero vuelve a tener importancia por la pandemia de COVID 19, así como lograr una cultura de calidad e identidad, la homogenización versus la innovación, entre otros.
Competencias en el profesorado universitario derivadas del impacto de la COVID-19
Authors: Martínez Mollineda Carlos , Martínez Pedraza Raxiel , Vázquez Coll Dainury
Published: March 2022

La pandemia Covid-19 ha puesto a prueba las formas de trabajar, convivir y producir en el mundo. Tema recurrente en las IES en aras de mantener la calidad, a la vez, ha producido transformaciones esenciales de innovación, en busca de una mayor efectividad y eficiencia. El objetivo es determinar el impacto derivado de la pandemia Covid-19 en las competencias claves que se pusieron a prueba en las IES por los docentes universitarios y su estado actual a partir de un diagnóstico científico en la preparación metodológica del profesorado universitario. La metodología utilizada es mixta, en la que se combinan métodos teóricos y empíricos. Los resultados revelan, el estado actual de las competencias de los docentes universitarios, para enfrentar los desafíos de la pandemia y los impactos fundamentales que ha provocado en las competencias de los profesores universitarios la pandemia, los cuales constituyen puntos de partida para trabajar en condiciones de aislamiento social, encierros y ausencia del contacto personal entre profesor alumno. En estos resultados consiste la importancia teórica-metodológica y práctica de la investigación. Finalmente, se presenta la discusión y las conclusiones con una síntesis de conocimientos importantes para enfrentar cambios trascendentales e innovaciones metodológicas y técnicas en la educación superior.
Overwiev of general plant toxicology uses and adverse effects
Authors:   Universidad Autónoma de Zacatecas, GONZÁLEZ-GARCÍA Arcelia , HERNÁNDEZ-SALAS Claudia ,   Universidad Autónoma de Zacatecas, MARTÍNEZ-ORTIZ Rosa María ,   Universidad Autónoma de Zacatecas, GONZÁLEZ-MARTÍNEZ Lilia ,   Universidad Autónoma de Zacatecas
Published: March 2022

That is why this work aims to know the generalities and the toxic substances include those of the organic and inorganic type. Hence, those of the organic type can be ethanol, most of the medicines and poisons of both animal and vegetable and pharmacological origin. Regarding inorganics, we can consider heavy metals, as well as caustic toxins such as sodium hydroxide. Chemical exposure today in the social environment can be very aggressive in extremely low doses. Speaking of any chemical it can be toxic if it is consumed, ingested or absorbed in excess. This can be through food, water, air, or other sources. Therefore, individuals can respond to toxic chemicals in different ways since some are often more sensitive to a specific chemical and can be excessively dangerous. Toxicological effect when supplying plants such as castor, caper flower and giant in male wistar spraley rats.
Early trauma as conditioning of psychopathology in adult women
Authors: AGUILAR-ZAVALA Herlinda , MORADO-CRESPO Lisette , VILLADA Carolina , TOVAR-VEGA Alma Rosa
Published: March 2022

Violence is a public health problem, with severe negative consequences on the mental and physical health of people, female primarily; one of five women reports more child abuse or maltreatment than each one of 13 men; women who have suffered some form of child abuse, have up to four times the risk of developing symptoms of depression in adult life. According to the WHO, between 1990 and 2013, people with depression or anxiety increased by 50%, from 416 million to 615 million. About 10% of the world's population is affected, and mental disorders account for 30% of the global burden of non-fatal disease. Humanitarian emergencies and conflict increase the need to expand therapeutic options. Major Depressive Disorder is characterized by severe mood alteration, displeasure and these affect the social, work, and personal areas; the persistence of the disorder could cause distress and physical and functional disability. The women are at twice the risk of suffering depression and suffer more severe depressive symptoms. In addition, women who have been victims of physical or sexual abuse have higher rates of mental health problems. Exposure to child abuse is associated with a markedly increased risk of psychiatric and medical disorders; The hypothalamic-pituitary-adrenal (HPA) axis is one of the main signaling pathways activated in response to stress and trauma. Alterations in the HPA axis or allostatic load are a psychophysiological condition due to the chronic persistence of child abuse, increasing the risk of suffering from mental disorders in adulthood. It is necessary to emphasize the importance of early trauma when psychiatric diagnosis, offer better treatment options, and stop the family chain of adverse events.
Cashew bagasse (Anacardium occidentale L.) as a source of fiberantioxidant and its possible use in lipoinflammation models
Authors: HERNÁNDEZ-PÉREZ Susana , RAMÍREZ-HIGUERA Abril , CHÁVEZ-REYES Yanet , OLIART-ROS Rosa María
Published: March 2022

Diet has a strong influence on health so that people with good eating habits and moderate exercise decrease the chance of developing diseases. As a result, the consumption of foods containing compounds with a value-added to the per se nutrient value is recommended; these compounds are known as bioactive compounds, such as fiber and antioxidants, which have been related to the decrease of oxidative stress and inflammation present in obesity and that, when not treated, they trigger multiple conditions such as diabetes, hypertension, metabolic syndrome, insulin resistance, and cardiovascular diseases. Cashew (Anacardium occidentale L.) is a fruit from Brazil that serves as a possible source of fiber-antioxidant by containing phenolic compounds and dietary fiber.
Methods of physical control of pathogenic microorganisms in hospital areas
Authors: SÁNCHEZ-OTERO María Guadalupe , PANIAGUA-MARTÍNEZ Ingrid , TEMICHE-CHI Diana Michel , ALEXANDER-AGUILERA Alfonso
Published: March 2022

Hospitals are establishments that are open 24 hours a day, 365 days a year, and are responsible for providing the necessary care to patients, there are hospitals of different levels and each one of them fulfills its mandate with different equipment and materials. Cleaning and disinfection are important issues to address, so this paper explains under reliable information, the different physical methods that have been implemented to improve the cleaning process every day and to control the levels of viable pathogen microorganisms installed on surfaces or equipment, there are also chemicals that damage health, the above is distributed in different hospital areas where there is contact between health personnel, patient, administrative workers, family members, and others. The administration of physical disinfection methods such as sterilization by dry or wet methods, radiation, filtration, electricity, have shown to be effective over the years and have been reflected in the controls carried out by Mexico's Secretary of Health or various institutions responsible for implementing cleaning protocols and that these are applied. Within a hospital, everything must be planned for good work performance and that the impact is favorable, with the information provided by this research is expected to achieve a social impact especially in health centers or hospitals, so that the problems that occur every day are decreasing.
Cuentos incompletos para el desarrollo del pensamiento crítico y creativo en niños
Authors: Vásquez Sonia , Ruiz-Pérez Aurelio
Published: March 2022

La investigación tuvo como objetivo diseñar un modelo de estrategia de cuentos incompletos para desarrollar el pensamiento crítico y creativo en niños de 04 años de edad. La investigación fue básica de nivel propositivo con diseño no experimental y enfoque metodológico cuantitativo. Se trabajó con una muestra de 92 niños de la Institución Educativa Inicial N° 004 de Chiclayo (Lambayeque - Perú) que fueron seleccionados aleatoriamente. Se elaboró y aplicó un test sobre el pensamiento crítico y creativo en el cual se consideró subdimensiones e indicadores. Dicho instrumento fue validado mediante juicio de expertos. Como resultado se obtuvo que más de la mitad de los niños tenían un nivel medio de desarrollo del pensamiento crítico y creativo. Se llegó a concluir que el modelo propuesto es un aporte novedoso para la educación al permitir que los niños mejoren estos pensamientos cuando dicha propuesta sea aplicada.
Multiple three-dimensional bottleneck barrier heights regarding fluctuated threshold voltage by ion implantation to source and drain extensions of silicon-on-insulator triple-gate fin-type field-effect transistors
Authors: Tsutsumi Toshiyuki
Published: March 2022

We study numerically on multiple three-dimensional bottleneck barrier heights (BBHs3D) which might be origins of the fluctuated threshold voltage (V
th) induced by random dopant fluctuation, depending on a drain voltage (V
d). It is confirmed from variance inflation factor that multiple regression analysis with all the BBHs3D is not suitable to investigate the fluctuated V
th. Since 3D bottleneck barrier height minimum (BBH3D,min) has a very high correlation with the other BBHs3D, simple regression analysis with even only one BBH3D,min has a very high correlation with the V
th. There is an optimal ordinal number for multiple BBHs3D to be considered to investigate the fluctuated V
th. It has been demonstrated that the V
th can be expressed more accurately by using my proposed method of simple regression analysis considering optimal multiple BBHs3D. Although the optimal multiple BBHs3D decreases when the V
d increases, the improvement is relatively similar regardless of the V
d.
Theoretical investigation of vacancy related defects at 4H-SiC(0001̅)/SiO2 interface after wet oxidation
Authors: Tsunasaki Mukai , Ono Tomoya , Uemoto Mitsuharu
Published: March 2022

The stability and formation mechanism of the defects relevant to silicon and carbon vacancies at the 4H-SiC(

000

1

¯

)/SiO2 interface after wet oxidation are investigated by first-principles calculation based on the density functional theory. The difference in the total energy of the defects agrees with the experimental results concerning the density of defects. We found that the characteristic behaviors of the generation of defects are explained by the positions of vacancies and antisites in the SiC(

000

1

¯

) substrate and that the formation of silicon and carbon vacancies is relevant to the generation mechanism of defects. The generation of silicon and carbon vacancies is attributed to the termination of dangling bonds by H atoms introduced by wet oxidation, resulting in the generation of carbon-antisite–carbon-vacancy and divacancies defects in wet oxidation.
EFFECT OF ADDING ARTICHOKE LEAVES EXTRACTPOWDER (CYnarascolymus L.) TO THE DIET ON THE PRODUCTIVE PERFORMANCEOFBROILERS.
Authors: Al- Masari A.I. , Al-Himdany H.Q.
Published: March 2022

This study was conducted at the poultry farm Animal Production Department, Abu Ghraib , College of Agricultural Engineering Sciences, University of Baghdad, during theperiod from 10/31/2020 to 12/11/2020. to study the effect of adding two different levels of artichoke  leaves extracts powder to the diet and for different periods  to rations on the productive performance of broiler chickens.One hundred thirty five unsexedcommercial hybrid broiler chicks (Ross 308), oneday old, 42.47 g/  its initial body weightwere used in this experiment, The birds were randomly distributed among three treatments, each treatment contained 45 birds, with three replicates, and each replicate contained 15 birds. The chicks of the first treatment (T1) were fed a standard diet for broilers free of addition, while the chicks of the T2 and T3 treatment were fed a standard diet for broilers in addition to the artichoke  leaves extract powder at a levels 0.5 and 1 g/kg diet respectively. The results  obtainedindicated that adding artichoke  leaves extract powder at two different levels to broiler diets led to a significant (P<0.05) superiority (P<0.05) for treatment T2 and T3 in the productive performance of body weight rates compared to the control treatment. In the average cumulative weight gain 1-6 week compared to the control treatment (T1), the T3 treatment also recorded a significant (P<0.05)increase  superiority (P<0.05) in the amount of cumulative feed consumption and feed conversion factor compared to the treatment T1, T2, In conclusion, the resultsindicate that supplementing artichoke leaves extractpowder to the diet showed a ssignificantin Improving in the  productiveperformance of broiler.
Síndrome de Li-Fraumeni
Authors: Insuasty-Enríquez Jesús Solier , Ortega Apraez Valeria , Arias-Quiroz Eduardo Javier , Alarcón-Tarazona Martha Liliana , Calderón-Cortés Carlos Alberto
Published: March 2022

El síndrome de Li-Fraumeni (SLF) es un trastorno autosómico dominante hereditario con predisposición al cáncer, está asociado con anomalías en el gen de la proteína tumoral p53 (TP53), que se manifiesta por una amplia gama de neoplasias malignas que aparecen a una edad temprana. Se expone al caso de un adulto joven en quien presentaremos este diagnóstico, y  se describen las perspectivas terapéuticas en investigación.
Púrpura trombocitopénica posterior a vacunación contra covid-19
Authors: Dulcey Sarmiento Luis Andrés , Caltagirone-Micelli Raimondo , Ruge-Serrano Alvaro Luis , Cantilllo-Reines Manuel David , Hernández-Anaya Pedro Nel , Henao-Niño Cristian Ornandy
Published: March 2022

Introducción: La pandemia por COVID-19 ha generado un costo inexorable a los gobiernos y una mortalidad elevada en términos generales, el proceso de vacunación es la única estrategia efectiva en disminuir la morbimortalidad en general, sin embargo, dicha administración no está exenta de riesgos.

Presentación del caso: Presentamos el caso clínico de una paciente de género femenino de la séptima decada quien es vacunada contra el COVID-19 y tras 4 días posteriores a la segunda dosis de vacuna anti COVID-19 comienza a presentar lesiones purpúricas que inician en miembros inferiores y ascienden progresivamente hasta el tronco asociado a artralgias intensas, dolor abdominal y nauseas, es ingresada encontrándose recuentos plaquetarios menores a 10 mil plaquetas, se hace el diagnostico de una purpura trombocitopénica inmune asociada a la vacuna de ASTRAZENECA contra COVID-19 iniciándose terapia inmunosupresora especifica.

Discusión: El presente caso constituye la aparición de una Purpura trombocitopénica idiopática, patología poco frecuente con un amplio repertorio de eventos desencadenantes encontrándose las infecciones y reacciones vacunales dentro de los principales detonantes. La presente reacción vacunal es poco frecuente siendo lo anecdótico en específico la presencia de purpura trombocitopénica inmune, hasta el momento son muy escasas las descripciones en la literatura sobre este tipo de reacción vacunal razón por la cual se decide recopilar y publicar el mismo mencionando la evidencia científica disponible más reciente sobre el tema.
Derecho Internacional Ambiental: dogmática y tutelas ambientales
Authors: Gutiérrez González Alicia
Published: March 2022

Nava Escudero, César, Derecho Internacional Ambiental: dogmática y tutelas ambientales, Editorial Porrúa, México, 2021, 301 pp. ISBN 978-60-7093-686-9.
identidad (habitus) y la intersubjetividad de los comerciantes de los mercados móviles de la Ciudad de México como coadyuvantes en la participación de sus asambleas y construcción del capital social
Authors: García Mayo Guillermo
Published: March 2022

La presente investigación se propone averiguar cómo la identidad (habitus) y la intersubjetividad de los comerciantes de los mercados móviles coadyuvan a la participación en las asambleas y a crear un capital social sólido que beneficie a toda la comunidad. En este sentido, existen problemas entre comerciantes que afectan la convivencia y funcionamiento de los bazares; el género como parte de la identidad de los comerciantes puede contribuir al mejoramiento. La metodología que se empleó fue mixta, se aplicaron 152 encuestas a comerciantes del Bazar del Oro y a 115 comerciantes del Bazarte Obregón, asimismo, se entrevistaron a cinco comerciantes de cada uno de los bazares. Los resultados obtenidos muestran que los comerciantes presentan una contradictoria identidad (habitus) e intersubjetividad, siendo en un bazar fundamento aceptable para participar en las asambleas y mejorar el capital social, pero para otro es todo lo contrario.
A COMPARATIVE STUDY OF METOCLOPRAMIDE VERSUS ONDANSETRON FOR POSTOPERATIVE NAUSEAAND VOMITING (PONV) IN ELECTIVE LOWER SEGMENT CAESAREAN SECTION UNDER SPINALANAESTHESIA
Authors: Sharma Rajeev , Singh Jatav Lakhan
Published: March 2022

Background : Caesarean section is one of the most prevalent surgical procedures among women. Pain, nausea and vomiting are the most common
adverse effects of surgery, which are reported in more than 66% of patients undergoing caesarean section under spinal anesthesia
Methods: A Hospital based, Prospective, Randomized, Double-Blind Interventional study was conducted in the Department of Anaesthesiology
and Critical Care, at Zanana hospital and Mahila Chikitsalya, SMS Medical College, Jaipur. after obtaining the permission from the institutional
ethics committee and after obtaining written informed consent in 84 patients aged above 18 years belonging to ASA grade 1 and 2 scheduled to
undergo elective LSCS under spinal anaesthesia.
Results: Incidence of nausea was signicantly more in group B than groups Afrom 1 hrs starting, incidence of vomiting decreased in group-Athan
group-B, incidence of retching was signicantly more in group B than groups Aat 2 hrs.
Conclusion: Ondansetron (4 mg=2 ml) dose was better than metoclopramide (4 mg=2 ml) in patients undergoing caesarean section under spinal
anesthesia
A RARE CASE OF SPONTANEOUS CYSTOGASTROSTOMY IN A PSEUDOCYST OF PANCREAS
Authors: Bhandarwar Ajay H , E Tandur Amarjeet , K Rathod Akshay , Kharmutee Geoffrey , R Honakeri Savitri , Dharne Monika
Published: March 2022

BACKGROUND: Pancreatic pseudocysts (PPs), common sequelae of acute or chronic pancreatitis and trauma, are uid collections arising in or
adjacent to the pancreas enclosed by a wall of brous granulation tissue, but lacking a true epithelial lining. It is the most common complication of
pancreatitis. Hence, accurate diagnosis and timely management is important. Spontaneous resolution occurs in more than 80% cases. In case of
persistence or specic indications, endoscopic intervention and surgical management is considered. Spontaneous rupture is a very rare and serious
complication of pseudocyst of pancreas and should be managed carefully whenever encountered as it can cause severe peritonitis and requires
emergent surgical exploration.
We describe a case of a 42-year-old, alcoholic male patient who came to casualty with complaints of pain over abdomen since 4 days and was
diagnosed with acute on chronic pancreatitis with pseudocyst of pancreas who developed spontaneous rupture of pseudocyst into body of stomach
and was managed conservatively.
Spontaneous resolution of pancreatic pseudocyst have been reported with acute gastrointestinal bleed, extension into the biliary tree and
pelvicalceal system. Spontaneous rupture of pseudocyst into the body of stomach is very rare that can be managed conservatively, which avoids
surgical intervention and hence decrease in mortality rate among these patients.
ALCOHOL : A PROVOCATING FACTOR IN MALE CEREBRAL VENOUS THROMBOSIS – A PROSPECTIVE ANALYSIS IN WESTERN RAJASTHAN
Authors: Prasad Pratibha
Published: March 2022

BACKGROUND : Cerebral venous thrombosis is an uncommon cause of headache in our daily practice. However there is a need to identify its
various provoking factors because timely and appropriate therapy can reverse the disease process , its acute complications and long term sequel.
OBJECTIVE : To study the clinical prole in male Cerebral Venous Thrombosis patients .
METHODS AND MATERIAL : This is a prospective cross sectional study of twenty ve male Cerebral Venous Thrombosis (CVT) patients
diagnosed in outpatient clinic of neurology department at Dr S N medical college from the September , 2014 to august , 2018. Their ages ranged
from 10 to 70 years with mean age of onset 31 yrs. All patients after taking informed consent with history suggestive of CVTand later diagnosed
by imaging of brain ( MRI and MRV) were included.
STATISTICALANALYSIS USED: All data were expressed as mean or patient's number (n) and percentage (%) as appropriate
RESULTS: Among 25 male CVT patients , majority were young seen in 20-30yrs with mean age of 31yrs. Most common clinical presentation
was headache [n=25(100%)] with or without vomiting followed by seizures [n=10 (40%)]. Most common site involved was transverse sinus
[n=23(92%)]. Papilledema was observe in 21 patients (84%). Alcoholism [n=8 (32%)] and hyperhomocystenemia [n=6(24%)] were the risk
factors seen in male CVT.
CONCLUSION: Cerebral Venous Thrombois is found to be signicantly high in alcoholic males. Compared to other Indian studies there was not
much disparity in clinical prole and risk factors.
RISK FACTORS AND CLINICAL CHARACTERISTICS OF PEPTIC ULCER PERFORATION IN SECONDARY REFERRAL CENTER OF WEST BENGAL
Authors: Deb Diptanu , Mukherjee Ramanuj , Jana Debarshi
Published: March 2022

INTRODUCTION: Peptic ulcer diseases (PUD) are dened as erosions in the gastric or duodenal mucosa that extend through the muscularis
mucosae.
AIM AND OBJECTIVES: To elucidate the risk factors and characteristics causing perforated peptic ulcer. This study is aimed to investigate the
risk factors and characteristics of perforated peptic ulcer using clinical data.
MATERIAL AND METHODS: The study was conducted at General Surgery Department and Emergency Department of Imambara District
Hospital, Hooghly, West Bengal No of case - 60 patients May 2018 to May 2019, 12 months Patients who were 18 years old or above.
CONCLUSION: In our study we found that the major risk factors associated with peptic (stomach, duodenum) ulcer perforation were Male,
NSAIDs, Smoking, Alcohol, Comorbidities, lower socioeconomic status; acute onset of pain etc
“CORRELATION OF SPECIFIC ANA(IIF) PATTERN AND ANTIBODIES DETECTED IN ANA BLOT TEST IN VARIOUS AUTOIMMUNE DISORDERS: A PROSPECTIVE STUDY”
Authors: Pramod Bokey Chinmayi , T. Deshmukh Anil , Soni Ramawatar , A. Tayde Ashish
Published: March 2022

Background: One of the central features of the immune system is the capacity to mount an inammatory response to potentially harmful foreign
materials while avoiding damage to self-tissues. Autoimmunity is dened as an immune response leading to reaction with self-antigen, this may be
a harmless phenomenon, identied only by the presence of low-titre autoantibodies or autoreactive T cells. These are a major cause of chronic
morbidity and disability, affecting up to 1 in 30 adults at some point during life. Autoimmune diseases result from the failure of immune tolerance,
the process by which the immune system recognises and accepts self-tissue. Materials And Methods Hospital based Observational study. Total
152 cases were studied with suspected connective tissue disorders attending OPD/IPD in tertiary care hospital in One and a half years (January
2020 to July 2021), but only 57 out 0f 152 cases were screened by ANA IIF Test and ANA BLOT Test both. Result: ANA positivity was more
observed in females. Autoimmune disorder was more common in the age group of 20-40 years about 22 cases (38.6%). Most common pattern
observed was Homogenous (n=20, 48.78%). Most common band observed is dsDNA (14.92%) followed by SS/RO 60 (13.43%) PO (11.94%),
Histone (10.44%) and Nucleosome (10.44%). The sensitivity, specicity, positive predictive value, negative predictive value of ANA Blot after
comparing it with ANA IIF is 70.73 %, 87.50%, 93.54%, 53.84% respectively. Conclusion: In conclusion, detection of ANA by indirect
immunouorescence is the most cost - effective screening test in investigating autoimmune disease. ALine-Immuno Assay is performed for further
conrmation and detection of specic antibody in sera which can be quantitated with ELISA/RIA/CLIA methods and can help in assessing the
prognosis, disease activity and monitoring of therapy for a particular auto-immune disorder. However, despite their easy use, line immunoassays
have some drawbacks including lack of sensitivity and specicity for certain antigens.
DETERMINATION OF ANTI-INFLAMMATORY ACTIVITY OF GERMINATED BROWN RICEoryza Sativa L. USING ALUMINIUM INDUCED CHICK EGGS
Authors: Nazeema T.H. , Parvathavardhini D , Vijayan Lakshmi
Published: March 2022

Brown rice is most versatile grain with plenty of nutrient. Studies proved that germinated brown rice has so many advantages when compared to
white rice. Inammation is a immune response that is triggered by various factors such as pathogens, damaged cells and other toxic compounds.
There plenty of commercial drug available for the treatment of inammation but most of them have side effect. Some times the risk factors leads life
threatening. In this study we check the anti-inammatory activity of GBR rice using Aluminium toxicity induced chick eggs. We focus on the
phytochemical analysis, GC-MS analysis, inhibition of albumin denaturation and HET-CAM test.
FUNCTIONAL OUTCOME AND EVALUATION OF RESULTS OF FRACTURES OF FEMUR TREATED BY DUAL IMPLANTATION
Authors: Chanda Ashoke Kumar , Bose Gourab , Dugar Neeraj , Banerjee Kallol
Published: March 2022

Background: Fractures of femur comprise a majority of lower limb trauma.The evaluation and management of patients with femoral fractures has
evolved on the basis of improved understanding of local anatomy and biomechanics of xation techniques.Non union and infection are still the two
most common problems we encounter in day to day practice.In this study we aim to evaluate the functional outcome and results of dual
implantation on these femoral fractures and it's effect on bone healing and early weight bearing particularly in cases of non union,fractures prone to
non union etc
Methods: The study was conducted on a group of patients attending our institution over a period of two years.Patients with fractures of femur
meeting our inclusion and exclusion criteria requirements were taken up for surgery and subsequently evaluated for the following parameters such
as functional range of motion of knee,average time to weight bearing,time taken for radiological union.
Results: 30 patients were evaluated in the age group of 12-70 years in a 2 year period.Majority of the patients achieved union at 12-16 weeks and
nearly 70% of patients commenced partial weight bearing by 8-9 weeks.Majority of the patients had favourable knee and hip scores.
Conclusion: Overall from this study Dual implantation in fractures of femur led to early radiological union,early weight bearing and favourable
range of motion of knee particularly in cases of non union and other complex cases.