bluuebunny/crossref_metadata_2025 huggingface dataset:
Shear cutting induced residual stresses in involute gears and resulting tooth root bending strength of a fineblanked gear
Authors: Müller Daniel , Stahl Jens , Nürnberger Anian , Golle Roland , Tobie Thomas , Volk Wolfram , Stahl Karsten
Published: February 2021

The manufacturing of case-hardened gears usually consists of several complex and expensive steps to ensure high load carrying capacity. The load carrying capacity for the main fatigue failure modes pitting and tooth root breakage can be increased significantly by increasing the near surface compressive residual stresses. In earlier publications, different shear cutting techniques, the near-net-shape-blanking processes (NNSBP’s), were investigated regarding a favorable residual stress state. The influence of the process parameters on the amount of clean cut, surface roughness, hardness and residual stresses was investigated. Furthermore, fatigue bending tests were carried out using C-shaped specimens. This paper reports about involute gears that are manufactured by fineblanking. This NNSBP was identified as suitable based on the previous research, because it led to a high amount of clean cut and favorable residual stresses. For the fineblanked gears of S355MC (1.0976), the die edge radii were varied and the effects on the cut surface geometry, hardness distribution, surface roughness and residual stresses are investigated. The accuracy of blanking the gear geometry is measured, and the tooth root bending strength is determined in a pulsating test rig according to standardized testing methods. It is shown that it is possible to manufacture gears by fineblanking with a high precision comparable to gear hobbing. Additionally, the cut surface properties lead to an increased tooth root bending strength.
Clinicopathological impacts of DNA methylation alterations on pancreatic ductal adenocarcinoma: prediction of early recurrence based on genome-wide DNA methylation profiling
Authors: Endo Yutaka , Fujimoto Mao , Ito Nanako , Takahashi Yoriko , Kitago Minoru , Gotoh Masahiro , Hiraoka Nobuyoshi , Yoshida Teruhiko , Kitagawa Yuko , Kanai Yae , Arai Eri
Published: February 2021

Purpose

The present study was conducted to clarify the clinicopathological impacts of DNA methylation alterations on pancreatic ductal adenocarcinoma (PDAC).

Methods

Genome-wide DNA methylation screening was performed using the Infinium HumanMethylation450 BeadChip, and DNA methylation quantification was verified using pyrosequencing. We analyzed fresh-frozen tissues from an initial cohort (17 samples of normal control pancreatic tissue [C] from 17 patients without PDAC, and 34 samples of non-cancerous pancreatic tissue [N] and 82 samples of cancerous tissue [T] both obtained from 82 PDAC patients) and formalin-fixed paraffin-embedded T samples from 34 patients in a validation cohort.

Results

The DNA methylation profiles of N samples tended to differ from those of C samples, and 91,907 probes showed significant differences in DNA methylation levels between C and T samples. Epigenetic clustering of T samples was significantly correlated with a larger tumor diameter and early recurrence (ER), defined as relapse within 6 months after surgery. Three marker CpG sites, applicable to formalin-fixed paraffin-embedded surgically resected materials regardless of their tumor cell content, were identified for prediction of ER. The sensitivity and specificity for detection of patients belonging to the ER group using a panel combining these three marker CpG sites, including a CpG site in the CDK14 gene, were 81.8% and 71.7% and 88.9% and 70.4% in the initial and validation cohorts, respectively.

Conclusion

These findings indicate that DNA methylation alterations may have a clinicopathological impact on PDAC. Application of our criteria will ultimately allow prediction of ER after surgery to improve the outcome of PDAC patients.
Dispersing Obnoxious Facilities on a Graph
Authors: Grigoriev Alexander , Hartmann Tim A. , Lendl Stefan , Woeginger Gerhard J.
Published: February 2021

We study a continuous facility location problem on a graph where all edges have unit length and where the facilities may also be positioned in the interior of the edges. The goal is to position as many facilities as possible subject to the condition that any two facilities have at least distance $$\delta$$
δ
from each other. We investigate the complexity of this problem in terms of the rational parameter $$\delta$$
δ
. The problem is polynomially solvable, if the numerator of $$\delta$$
δ
is 1 or 2, while all other cases turn out to be NP-hard.
Robotic-assisted cholecystectomy is superior to laparoscopic cholecystectomy in the initial training for surgical novices in an ex vivo porcine model: a randomized crossover study
Authors: Willuth E. , Hardon S. F. , Lang F. , Haney C. M. , Felinska E. A. , Kowalewski K. F. , Müller-Stich B. P. , Horeman T. , Nickel F.
Published: February 2021

Background

Robotic-assisted surgery (RAS) potentially reduces workload and shortens the surgical learning curve compared to conventional laparoscopy (CL). The present study aimed to compare robotic-assisted cholecystectomy (RAC) to laparoscopic cholecystectomy (LC) in the initial learning phase for novices.

Methods

In a randomized crossover study, medical students (n = 40) in their clinical years performed both LC and RAC on a cadaveric porcine model. After standardized instructions and basic skill training, group 1 started with RAC and then performed LC, while group 2 started with LC and then performed RAC. The primary endpoint was surgical performance measured with Objective Structured Assessment of Technical Skills (OSATS) score, secondary endpoints included operating time, complications (liver damage, gallbladder perforations, vessel damage), force applied to tissue, and subjective workload assessment.

Results

Surgical performance was better for RAC than for LC for total OSATS (RAC = 77.4 ± 7.9 vs. LC = 73.8 ± 9.4; p = 0.025, global OSATS (RAC = 27.2 ± 1.0 vs. LC = 26.5 ± 1.6; p = 0.012, and task specific OSATS score (RAC = 50.5 ± 7.5 vs. LC = 47.1 ± 8.5; p = 0.037). There were less complications with RAC than with LC (10 (25.6%) vs. 26 (65.0%), p = 0.006) but no difference in operating times (RAC = 77.0 ± 15.3 vs. LC = 75.5 ± 15.3 min; p = 0.517). Force applied to tissue was similar. Students found RAC less physical demanding and less frustrating than LC.

Conclusions

Novices performed their first cholecystectomies with better performance and less complications with RAS than with CL, while operating time showed no differences. Students perceived less subjective workload for RAS than for CL. Unlike our expectations, the lack of haptic feedback on the robotic system did not lead to higher force application during RAC than LC and did not increase tissue damage. These results show potential advantages for RAS over CL for surgical novices while performing their first RAC and LC using an ex vivo cadaveric porcine model.

Registration number

researchregistry6029

Graphic abstract
Optimal ICG dosage of preoperative colonoscopic tattooing for fluorescence-guided laparoscopic colorectal surgery
Authors: Ahn Hong-min , Son Gyung Mo , Lee In Young , Shin Dong-Hoon , Kim Tae Kyun , Park Su Bum , Kim Hyung Wook
Published: February 2021

Background

Indocyanine green (ICG) is a multifunctional dye used in tumor localization, tissue perfusion, and lymph node (LN) mapping during fluorescence-guided laparoscopic colorectal surgery.

Purpose

This study aimed to establish the optimal protocol for preoperative endoscopic submucosal ICG injection to perform fluorescence lymph node mapping (FLNM), along with undisturbed fluorescent tumor localization and ICG angiography during a single surgery.

Methods

Colorectal cancer patients (n = 192) were enrolled from May 2017 to December 2019. Colonoscopic submucosal ICG injection was performed 12 to 18 h before surgery. ICG injection protocols were modified based on the total injected ICG (mg) and tattooing site number. The concentrations of ICG were gradually decreased from the standard dose (2.5 mg/ml) to the minimum dose (0.2 mg/ml). Successful FLNM (FLNM-s) was defined as distinct fluorescent LNs observed under NIR camera. The patient’s age, sex, body mass index (BMI), stage, cancer location, obstruction, and laboratory findings were compared between the FLNM-s and failed FLNM (FLNM-f) groups to identify clinical and pathological factors that affect FLNM.

Results

In the ICG dose section of 0.5 to 1 mg, the success rate was highest within all functions including FLNM, fluorescent tumor localization, and ICG angiography. FLNM-s was related to ICG dose (0.5–1 mg), multiple submucosal injections, location of cancer, camera light source, and lower BMI. In the multivariate analysis, camera light source, non-obesity, and multiple injections were independent factors for FLNM-s). The mean total number of harvested LNs was significantly higher in the FLNM-s group than that in the FLNM-f group (p < 0.001). The number of metastatic lymph nodes was comparable between the two groups (p = 0.859).

Conclusions

Preoperative, endoscopic submucosal ICG injection with dose range 0.5 to 1 mg would be optimal protocol for multifunctional ICG applications during fluorescence-guided laparoscopic colorectal surgery.
Schizophrenia polygenic risk is associated with child mental health problems through early childhood adversity: evidence for a gene–environment correlation
Authors: Bolhuis Koen , Steenkamp Lisa R. , Blanken Laura M. E. , Neumann Alexander , Jansen Philip R. , Hillegers Manon H. J. , Cecil Charlotte A. M. , Tiemeier Henning , Kushner Steven A.
Published: February 2021

Previous studies have shown that schizophrenia polygenic risk predicts a multitude of mental health problems in the general population. Yet it is unclear by which mechanisms these associations arise. Here, we explored a possible gene–environment correlation in the association of schizophrenia polygenic risk with mental health problems via childhood adversity. This study was embedded in the population-based Generation R Study, including N = 1901 participants with genotyping for schizophrenia polygenic risk, maternal reporting of childhood adversity, and Child Behaviour Checklist measurement of mental health problems. Independent replication was attempted in the Avon Longitudinal Study of Parents and Children (ALSPAC; N = 3641). Associations were analysed with Poisson regression and statistical mediation analysis. Higher burden of schizophrenia polygenic risk was associated with greater exposure to childhood adversity (P-value threshold < 0.5: Generation R Study, OR = 1.08, 95%CI 1.02–1.15, P = 0.01; ALSPAC, OR = 1.02, 95%CI 1.01–1.03, P < 0.01). Childhood adversities partly explained the relationship of schizophrenia polygenic risk with emotional, attention, and thought problems (proportion explained, range 5–23%). Direct effects of schizophrenia polygenic risk and adversity on mental health outcomes were also observed. In summary, genetic liability to schizophrenia increased the risk for mental health problems in the general paediatric population through childhood adversity. Although this finding could result from a mediated causal relationship between genotype and mental health, we argue that these observations most likely reflect a gene–environment correlation, i.e. adversities are a marker for the genetic risk that parents transmit to children. These and similar recent findings raise important conceptual questions about preventative interventions aimed at reducing childhood adversities.
Holistic principle for risk aggregation and capital allocation
Authors: Chong Wing Fung , Feng Runhuan , Jin Longhao
Published: February 2021

Risk aggregation and capital allocation are of paramount importance in business, as they play critical roles in pricing, risk management, project financing, performance management, regulatory supervision, etc. The state-of-the-art practice often includes two steps: (i) determine standalone capital requirements for individual business lines and aggregate them at a corporate level; and (ii) allocate the total capital back to individual lines of business or at more granular levels. There are three pitfalls with such a practice, namely, lack of consistency, negligence of cost of capital, and disentanglement of allocated capitals from standalone capitals. In this paper, we introduce a holistic approach that aims to strike a balance of optimality by taking into account competing interests of various stakeholders and conflicting priorities in a corporate hierarchy. While unconventional in its objective, the new approach results in an allocation of diversification benefit, which conforms to the diversification strategy of many risk management frameworks including regulatory capital and economic capital. The holistic capital setting and allocation principle provides a remedy to aforementioned problems with the existing two-step industry practice.
Morphologies and prognostic significance of left ventricular volume/time curves with cardiac magnetic resonance in patients with non-ischaemic heart failure and left bundle branch block
Authors: Aimo Alberto , Valleggi Alessandro , Barison Andrea , Salerni Sara , Emdin Michele , Aquaro Giovanni Donato
Published: February 2021

Patients with non-ischaemic systolic heart failure (HF) and left bundle branch block (LBBB) can display a wide or narrow pattern (WP/NP) of the systolic phase of the left ventricular (LV) volume/time (V/t) curve in cardiac magnetic resonance (CMR). The clinical and prognostic significance of these patterns is unknown. Consecutive patients with non-ischaemic HF, LV ejection fraction < 50% and LBBB underwent 1.5 T CMR. Maximal dyssynchrony time (time between the earliest and latest end-systolic peaks), systolic dyssynchrony index (standard deviation of times to peak volume change), and contractility index (maximum rate of change of pressure-normalized stress) were calculated. The endpoint was a composite of cardiovascular death, HF hospitalization, and appropriate defibrillator shock. NP was found in 29 and WP in 72 patients. WP patients had higher volumes and NT-proBNP, and lower LVEF. WP patients had a longer maximal dyssynchrony time (absolute duration: 192 ± 80 vs. 143 ± 65 ms, p < 0.001; % of RR interval: 25 ± 11% vs. 8 ± 4%, p < 0.001), a higher systolic dyssynchrony index (13 ± 4 vs. 7 ± 3%, p < 0.001), and a lower contractility index (2.6 ± 1.2 vs 3.2 ± 1.7, p < 0.05). WP patients had a shorter survival free from the composite endpoint regardless of age, NT-proBNP or LVEF. Nonetheless, WP patients responded more often to cardiac resynchronization therapy (CRT) than those with NP (24/28 [86%] vs. 1/11 [9%] responders, respectively; p < 0.001). In patients with non-ischaemic systolic HF and LBBB, the WP of V/t curves identifies a subgroup of patients with greater LV dyssynchrony and worse outcome, but better response to CRT.
Value sensitive design as a formative framework
Authors: Hendry David G. , Friedman Batya , Ballard Stephanie
Published: February 2021

In this article, we first offer a model of design knowledge types (know-about, know-that, know-how) and their interrelationships in value sensitive design. Then we demonstrate that value sensitive design is a formative framework, which provides a shaping influence on practice, enables creative appropriation, and supports theory and method development.
Development of the PARMS marker of the TAC1 gene and its utilization in rice plant architecture breeding
Authors: Gao Ju , Liang Haifu , Huang Juan , Qing Dongjin , Wu Hao , Zhou Weiyong , Chen Weiwei , Pan Yinghua , Dai Gaoxing , Gao Lijun , Deng Guofu
Published: February 2021

The ideal plant architecture is a new strategy for super high yield breeding of rice. Tiller angle is an important plant architecture character of rice. A reasonable tiller angle is a key factor for the ideal plant architecture and achieving high-yield breeding. Molecular design breeding is the most potential new direction of crop breeding in the future. The development of accurate and efficient functional molecular markers of target trait genes is crucial for molecular design breeding. The TAC1 (Tiller Angle Controlling) gene is the primary gene that regulates tiller angle in rice. This gene can be used to improve the compact plant architecture of indica and japonica rice varieties. The SNP variation from A to G at the fourth intron 3′ splicing point in TAC1 changes plant architecture. Based on the SNP variation, PM-TAC1 was successfully developed as a fluorescent functional molecular marker, via the penta-primer amplification refractory mutation system. Ninety-three rice materials were genotyped using this marker, and the marker was effectively used in rice plant architecture breeding. The successful development of this marker will contribute to the molecular breeding of rice plant architecture.
Proportion of children with cancer that have an indication for genetic counseling and testing based on the cancer type irrespective of other features
Authors: Nguyen Thi Minh Kha , Behnert Astrid , Pietsch Torsten , Vokuhl Christian , Kratz Christian Peter
Published: February 2021

In children with cancer, specific clinical features such as physical anomalies, occurrence of cancer in young relatives, specific cancer histologies, and unique mutation/methylation signatures may indicate the presence of an underlying cancer predisposition syndrome (CPS). The proportion of children with a cancer type suggesting a CPS among all children with cancer is unknown. To determine the proportion of children with cancer types suggesting an underlying CPS among children with cancer. We evaluated the number of children with cancer types strongly associated with CPS diagnosed in Germany between 2007 and 2016. Data were obtained from various sources including two national pediatric pathology reference laboratories for brain and solid tumors, respectively, various childhood cancer trial offices as well as the German Childhood Cancer Registry. Among 21,127 children diagnosed with cancer between 2007 and 2016, 2554 (12.1%) had a cancer type strongly associated with a CPS. The most common diagnoses were myelodysplastic syndrome and juvenile myelomonocytic leukemia, retinoblastoma, malignant peripheral nerve sheath tumor, infantile myofibromatosis, medulloblastomaSHH, rhabdoid tumor as well as atypical teratoid/rhabdoid tumor. Based on cancer type only, 12.1% of all children with cancer have an indication for a genetic evaluation. Pediatric oncology patients require access to genetic counselling and testing.
Hardware-in-the-loop simulation of wave energy converters based on dielectric elastomer generators
Authors: Moretti Giacomo , Scialò Andrea , Malara Giovanni , Muscolo Giovanni Gerardo , Arena Felice , Vertechy Rocco , Fontana Marco
Published: February 2021

Dielectric elastomer generators (DEGs) are soft electrostatic generators based on low-cost electroactive polymer materials. These devices have attracted the attention of the marine energy community as a promising solution to implement economically viable wave energy converters (WECs). This paper introduces a hardware-in-the-loop (HIL) simulation framework for a class of WECs that combines the concept of the oscillating water columns (OWCs) with the DEGs. The proposed HIL system replicates in a laboratory environment the realistic operating conditions of an OWC/DEG plant, while drastically reducing the experimental burden compared to wave tank or sea tests. The HIL simulator is driven by a closed-loop real-time hydrodynamic model that is based on a novel coupling criterion which allows rendering a realistic dynamic response for a diversity of scenarios, including large scale DEG plants, whose dimensions and topologies are largely different from those available in the HIL setup. A case study is also introduced, which simulates the application of DEGs on an OWC plant installed in a mild real sea laboratory test-site. Comparisons with available real sea-test data demonstrated the ability of the HIL setup to effectively replicate a realistic operating scenario. The insights gathered on the promising performance of the analysed OWC/DEG systems pave the way to pursue further sea trials in the future.
Always look on the bright side of life? Exploring the between-variance and within-variance of emotion regulation goals
Authors: Wilms R. , Lanwehr R. , Kastenmüller A.
Published: February 2021

Currently, emotion regulation goals are being perceived as highly situational. This assumption might be wrong, though, as the preeminent measure [the intraclass coefficient (1), ICC(1)] overestimates the proportion of within-variance under the condition of measurement error. We therefore empirically test whether emotion regulation goals represent more of a between-person or a within-person phenomenon, using the reliability-adjusted ICC(1). A total of 305 students participated in a daily diary study and answered a questionnaire about their emotion regulation goals in the most negative event of the day over the course of 9 days. Multilevel analyses suggest that emotion regulation goals vary more between persons than heretofore assumed, especially for hedonic goals, but also for social goals. Besides, we show substantial differences in the within-variance across individuals. We conclude by discussing theoretical implications for general and clinical psychology.
Geodesy, Geophysics and Fundamental Physics Investigations of the BepiColombo Mission
Authors: Genova Antonio , Hussmann Hauke , Van Hoolst Tim , Heyner Daniel , Iess Luciano , Santoli Francesco , Thomas Nicolas , Cappuccio Paolo , di Stefano Ivan , Kolhey Patrick , Langlais Benoit , Mieth Johannes Z. D. , Oliveira Joana S. , Stark Alexander , Steinbrügge Gregor , Tosi Nicola , Wicht Johannes , Benkhoff Johannes
Published: February 2021

In preparation for the ESA/JAXA BepiColombo mission to Mercury, thematic working groups had been established for coordinating the activities within the BepiColombo Science Working Team in specific fields. Here we describe the scientific goals of the Geodesy and Geophysics Working Group (GGWG) that aims at addressing fundamental questions regarding Mercury’s internal structure and evolution. This multidisciplinary investigation will also test the gravity laws by using the planet Mercury as a proof mass. The instruments on the Mercury Planetary Orbiter (MPO), which are devoted to accomplishing the GGWG science objectives, include the BepiColombo Laser Altimeter (BELA), the Mercury orbiter radio science experiment (MORE), and the MPO magnetometer (MPO-MAG). The onboard Italian spring accelerometer (ISA) will greatly aid the orbit reconstruction needed by the gravity investigation and laser altimetry. We report the current knowledge on the geophysics, geodesy, and evolution of Mercury after the successful NASA mission MESSENGER and set the prospects for the BepiColombo science investigations based on the latest findings on Mercury’s interior. The MPO spacecraft of the BepiColombo mission will provide extremely accurate measurements of Mercury’s topography, gravity, and magnetic field, extending and improving MESSENGER data coverage, in particular in the southern hemisphere. Furthermore, the dual-spacecraft configuration of the BepiColombo mission with the Mio spacecraft at higher altitudes than the MPO spacecraft will be fundamental for decoupling the internal and external contributions of Mercury’s magnetic field. Thanks to the synergy between the geophysical instrument suite and to the complementary instruments dedicated to the investigations on Mercury’s surface, composition, and environment, the BepiColombo mission is poised to advance our understanding of the interior and evolution of the innermost planet of the solar system.
Intra-Camera Supervised Person Re-Identification
Authors: Zhu Xiangping , Zhu Xiatian , Li Minxian , Morerio Pietro , Murino Vittorio , Gong Shaogang
Published: February 2021

Existing person re-identification (re-id) methods mostly exploit a large set of cross-camera identity labelled training data. This requires a tedious data collection and annotation process, leading to poor scalability in practical re-id applications. On the other hand unsupervised re-id methods do not need identity label information, but they usually suffer from much inferior and insufficient model performance. To overcome these fundamental limitations, we propose a novel person re-identification paradigm based on an idea ofindependentper-camera identity annotation. This eliminates the most time-consuming and tedious inter-camera identity labelling process, significantly reducing the amount of human annotation efforts. Consequently, it gives rise to a more scalable and more feasible setting, which we callIntra-Camera Supervised (ICS)person re-id, for which we formulate a Multi-tAsk mulTi-labEl (MATE) deep learning method. Specifically, MATE is designed for self-discovering the cross-camera identity correspondence in a per-camera multi-task inference framework. Extensive experiments demonstrate the cost-effectiveness superiority of our method over the alternative approaches on three large person re-id datasets. For example, MATE yields 88.7% rank-1 score on Market-1501 in the proposed ICS person re-id setting, significantly outperforming unsupervised learning models and closely approaching conventional fully supervised learning competitors.
Targeting mitochondrial dysfunction with small molecules in intervertebral disc aging and degeneration
Authors: Saberi Morteza , Zhang Xiaolei , Mobasheri Ali
Published: February 2021

The prevalence of rheumatic and musculoskeletal diseases (RMDs) including osteoarthritis (OA) and low back pain (LBP) in aging societies present significant cost burdens to health and social care systems. Intervertebral disc (IVD) degeneration, which is characterized by disc dehydration, anatomical alterations, and extensive changes in extracellular matrix (ECM) composition, is an important contributor to LBP. IVD cell homeostasis can be disrupted by mitochondrial dysfunction. Mitochondria are the main source of energy supply in IVD cells and a major contributor to the production of reactive oxygen species (ROS). Therefore, mitochondria represent a double-edged sword in IVD cells. Mitochondrial dysfunction results in oxidative stress, cell death, and premature cell senescence, which are all implicated in IVD degeneration. Considering the importance of optimal mitochondrial function for the preservation of IVD cell homeostasis, extensive studies have been done in recent years to evaluate the efficacy of small molecules targeting mitochondrial dysfunction. In this article, we review the pathogenesis of mitochondrial dysfunction, aiming to highlight the role of small molecules and a selected number of biological growth factors that regulate mitochondrial function and maintain IVD cell homeostasis. Furthermore, molecules that target mitochondria and their mechanisms of action and potential for IVD regeneration are identified. Finally, we discuss mitophagy as a key mediator of many cellular events and the small molecules regulating its function.
Increased resilience for manufacturing systems in supply networks through data-based turbulence mitigation
Authors: Bauer Dennis , Böhm Markus , Bauernhansl Thomas , Sauer Alexander
Published: February 2021

In manufacturing systems, a state of high resilience is always desirable. However, internal and external complexity has great influence on these systems. An approach is to increase manufacturing robustness and responsiveness—and thus resilience—by manufacturing control. In order to execute an effective control method, it is necessary to provide sufficient information of high value in terms of data format, quality and time of availability. Nowadays, raw data is available in large quantities. An obstacle to manufacturing control is the short-term handling of events induced by customers and suppliers. These events cause different kinds of turbulence in manufacturing systems. If such turbulences could be evaluated in advance, based on data processing, they could serve as aggregated input data for a control system. This paper presents an approach how to combine turbulence evaluation and the derivation of measures into a learning system for turbulence mitigation. Integrated in manufacturing control, turbulence mitigation increases manufacturing resilience and strengthens the supply network’s resilience.
Energy-Based Devices for Functional Vaginal Problems: Issues and Answers
Authors: Bujnak Alyssa , Crowder Carly A. , Krychman Michael L.
Published: February 2021

Vaginal rejuvenation is a marketing term that encompasses surgical and medical treatments for functional vaginal/vulvar problems including but not limited to genitourinary syndrome of menopause (GSM), sexual dysfunction, vaginal laxity, and stress urinary incontinence (SUI) and for esthetic concerns including dissatisfaction with vulvovaginal appearance. Multiple treatment options have become available for indications of functional vaginal problems. Noninvasive management options including the use of more novel treatments such as energy-based devices have gained interest. Previously, studies regarding the efficacy and safety of the energy-based devices for functional vaginal problems were mostly limited to cohort studies without sham treatment, control groups, randomization, or double blinding. As a result of this insufficient data in 2018, the FDA released a statement of warning against the use of energy-based devices in the treatment of functional vaginal problems or vaginal cosmetic procedures (Https://Www.Fda.Gov/Medical-Devices/Safety-Communications/Fda-Warns-Against-Use-Energy-Based-Devices-Perform-Vaginal-Rejuvenation-or-Vaginal-Cosmetic. 1–4, 2018).

Purpose of Review

This article reviews the most current treatment modalities in the realm of vaginal rejuvenation therapy with an emphasis on the efficacy and safety of the energy-based devices.

Recent Findings

In the most recent literature, there have been studies with improvements in study design that support the efficacy and the short-term safety of the energy-based devices.

More recent studies with improved study design evidence that the use of energy-based devices results in improvements in functional vaginal problems and that serious adverse events appear to be rare. The availability of these devices as treatment options for functional vaginal problems has the potential to impact patient by improving their symptoms and quality of life. Caution still remains however regarding their safety following a longer period of time after their use.
SEOM clinical guidelines for the treatment of head and neck cancer (2020)
Authors: Mesia R. , Iglesias L. , Lambea J. , Martínez-Trufero J. , Soria A. , Taberna M. , Trigo J. , Chaves M. , García-Castaño A. , Cruz J.
Published: February 2021

Head and neck cancers (HNC) are defined as malignant tumours located in the upper aerodigestive tract and represents 5% of oncologic cases in adults in Spain. More than 90% of these tumours have squamous histology. In an effort to incorporate evidence obtained since 2017 publication, the Spanish Society of Medical Oncology (SEOM) presents an update of the squamous cell HNC diagnosis and treatment guideline. Most relevant diagnostic and therapeutic changes from the last guideline have been updated: introduction of sentinel node biopsy in early oral/oropharyngeal cancer treated with surgery, concomitant radiotherapy with weekly cisplatin 40 mg/m2 in the adjuvant setting, new approaches for HPV-related oropharyngeal cancer and new treatments with immune-checkpoint inhibitors in recurrent/metastatic disease.
Perceived vulnerability to disease, knowledge about COVID-19, and changes in preventive behavior during lockdown in a German convenience sample
Authors: Stangier Ulrich , Kananian Schahryar , Schüller Johanna
Published: February 2021

The COVID-19 pandemic has called worldwide for strong governmental measures to contain its spread, associated with considerable psychological distress. This study aimed at screening a convenience sample in Germany during lockdown for perceived vulnerability to disease, knowledge about COVID-19, symptoms of depression and anxiety, and behavioral responses. In an online survey, 1358 participants completed the perceived vulnerability to disease scale (PVD), the Patient Health Questionnaire (PHQ-4), and questionnaires on knowledge about COVID-19 and self-perceived change in behaviors in response to COVID-19. Lower and upper quartiles of the PVD were used to classify individuals into low and high PVD. A confirmatory factor analysis supported three factors representing risk, preventive and adaptive behavior as behavioral responses to COVID-19 lockdown. A structural equation model showed that the score of the knowledge scale significantly predicted the self-reported increase in adaptive and preventive behavior. The score in the PVD-subscale Perceived Infectability predicted a self-reported increase in preventive behavior, whereas the Germ Aversion score predicted a self-reported increase in preventive and a decrease in risk behavior. The score in PHQ-4 predicted a higher score in the perceived infectability and germ aversion subscales, and a self-reported decrease in adaptive behavior. Low-, medium- and high-PVD groups reported distinct patterns of behavior, knowledge, and mental health symptoms. This study shows that perceived vulnerability to disease is closely linked to preventive behaviors and may enhance adaptation to COVID-19 pandemic.
Engaging Teachers and School Leaders in Participatory Data Analysis for the Development of a School-Based Mental Health Intervention
Authors: Neill Ruth D. , Best Paul , Lloyd Katrina , Williamson Janet , Allen Jack , Badham Jennifer , Tully Mark. A.
Published: February 2021

The success of school-based mental health interventions is often inconsistent, in part due to lack of input from teachers and students in the programme design. Therefore, the involvement and engagement of teachers in the co-production of an intervention, especially within data analysis, can create more innovative and effective solutions. This paper presents a teacher-led qualitative data analysis using a new approach within the field, participation theme elicitation. This approach will be used to gather information relevant to the initial development of a school-based mental health intervention. Teachers identified the following themes: (1) physical activity as a stress reliever, (2) programme facilitation, (3) exam pressure and (4) solutions to improve negative mental health. Results from the teacher-led analysis are broadly similar to previous research in the field. Our findings demonstrate that teachers can have a valuable input into research findings which should help address the development of a school-based mental health intervention. In summary, the findings suggest that the use of participatory theme elicitation is a valid and effective method to address the gaps and limitations of participatory qualitative data analysis.
Dried urine spots as sampling technique for multi-mycotoxin analysis in human urine
Authors: Schmidt Jessica , Lindemann Viktoria , Olsen Monica , Cramer Benedikt , Humpf Hans-Ulrich
Published: February 2021

A simple and effective approach for HPLC-MS/MS based multi-mycotoxin analysis in human urine samples was developed by application of dried urine spots (DUS) as alternative on-site sampling strategy. The newly developed method enables the detection and quantitation of 14 relevant mycotoxins and mycotoxin metabolites, including citrinin (CIT), dihydrocitrinone (DH-CIT), deoxynivalenol (DON), fumonisin B1 (FB1), T-2 Toxin (T-2), HT-2 Toxin (HT-2), ochratoxin A (OTA), 2′R-ochratoxin A (2′R-OTA), ochratoxin α (OTα), tenuazonic acid and allo-tenuazonic acid (TeA + allo-TeA), zearalenone (ZEN), zearalanone (ZAN), α-zearalenol (α-ZEL), and β-zearalenol (β-ZEL). Besides the spotting procedure, sample preparation includes enzymatic cleavage of glucuronic acid conjugates and stable isotope dilution analysis. Method validation revealed low limits of detection in the range of pg/mL urine and excellent apparent recovery rates for most analytes. Stability investigation of DUS displayed no or only slight decrease of the analyte concentration over a period of 28 days at room temperature. The new method was applied to the analysis of a set of urine samples (n = 91) from a Swedish cohort. The four analytes, DH-CIT, DON, OTA, and TeA + allo-TeA, could be detected and quantified in amounts ranging from 0.06 to 0.97 ng/mL, 3.03 to 136 ng/mL, 0.013 to 0.434 ng/mL and from 0.36 to 47 ng/mL in 38.5%, 70.3%, 68.1%, and 94.5% of the samples, respectively. Additional analysis of these urine samples with an established dilute and shoot (DaS) approach displayed a high consistency of the results obtained with both methods. However, due to higher sensitivity, a larger number of positive samples were observed using the DUS method consequently providing a suitable approach for human biomonitoring of mycotoxin exposure.
Do adults with non-communicable diseases meet the German physical activity recommendations?
Authors: Sudeck Gorden , Geidl Wolfgang , Abu-Omar Karim , Finger Jonas David , Krauß Inga , Pfeifer Klaus
Published: February 2021

Introduction

The numerous health benefits of physical activity (PA) for people with non-communicable diseases (NCDs) are well-documented. In Germany, there are limited data on whether adults with NCDs fulfill health-oriented PA recommendations. This study describes the prevalence of meeting PA recommendations among adults with select NCDs.

Method

Based on the national representative GEDA-2014/2015-EHIS (N = 24,016), the self-reported PA data of the European Health Interview Survey–Physical Activity Questionnaire (EHIS-PAQ) were classified with respect to fulfilling recommendations for health-enhancing aerobic activities (≥ 150 min per week with at least moderate intensity) and muscle strengthening (≥ 2 times per week). These binary indicators were used to analyze the association between the prevalence of sufficient PA and the self-reported presence of certain NCDs and multiple NCDs to reflect multimorbidity.

Results

Compared to the general adult population, sufficient aerobic PA was lower for most NCDs, with the lowest level among people with diabetes mellitus, obesity, stroke, chronic obstructive pulmonary disease (COPD), and depression. Compared to the general adult population, sufficient muscle strengthening was lower for some NCDs (diabetes mellitus, obesity, depression), but it was higher in people with musculoskeletal diseases (osteoarthritis, lower back pain). Multimorbidity was negatively associated with sufficient PA levels.

Conclusion

The study specifies the need to promote PA among adults with select NCDs to counteract insufficient levels of health-enhancing PA and to reduce the individual and societal burden of NCDs.
Nasal Septal Deviation After Surgically Assisted Rapid Maxillary Expansion
Authors: Seidita Francesco , de Azambuja Carvalho Pedro Henrique , Dos Sántos José Cleveilton , Dell’Aversana Orabona Giovanni , Califano Luigi , Gabrielli Mário Francisco Real , Filho Valfrido Antonio Pereira
Published: February 2021

Background and Aim

Surgically assisted rapid maxillary expansion (SARME) is a surgical technique widely used to correct deficiency of the transverse maxillary dimension. Although some studies investigated the effect of SARME on nasal and facial alterations, there is no evidence that correlates nasal septal deviation (NSD) to SARME as a possible postoperative sequel. The aim of this study is to address and quantify possible variations in the position of the nasal bony septum after SARME and identify any NSD as a postoperative outcome of this surgical technique.

Patients and Methods

This is a retrospective study, conducted at the Department of Oral and Maxillofacial Surgery of the University Hospital of Araraquara (Unesp, faculty of dentistry), SP, Brazil. Twenty-nine patients who underwent SARME were studied; every patient was evaluated by cone-beam computerized tomography (CBCT) before (T0) and six months after surgery (T1), and we collected the variation of nasal septal position by measuring the distance between the bony septum and the nasal lateral wall. Our measurements were carried out at the level of the head, midpoint and tail of the inferior turbinate.

Results

A mean NSD ranging from 0.4 to 1.2 mm was measured, and it is more pronounced at the anterior part of the bony septum. Twenty-seven patients (93.1%) presented minor changes in bony septum position; in 2 cases (6.8%), a significant NSD was found (p < 0.05).

Conclusion

A variation of bony nasal septum position can be expected in any direction after SARME, and it is more pronounced at anterior portion.
Angiographic evaluation of radial artery injury after transradial approach for percutaneous coronary intervention
Authors: Kanazawa Takenori , Shimamura Kiyotaka , Nagao Kazuya , Yukawa Hiroshi , Aida Kenji , Kobayashi Yohei , Takahashi Naoki , Nakagawa Eiichiro , Itoh Haruyasu , Hayashi Fujio , Makita Toshinori , Tanaka Masaru , Inada Tsukasa
Published: February 2021

The transradial approach for percutaneous coronary intervention (TRA-PCI) has been increasingly gaining popularity in clinical practice. However, its association with risk for long-term radial artery injury has not been yet thoroughly defined. We retrospectively examined the patients undergoing radial artery angiography (RAG) after TRA-PCI to determine the incidence and risk factors of radial artery injury. The study included 558 patients undergoing follow-up radial artery angiography at 12 month after TRA-PCI. Radial artery injury occurred in 140 patients (25%) with 3 distinct morphological patterns: focal radial artery stenosis (RAS) P.7,7: in 7 patients (1%), diffuse radial artery stenosis (RAS) in 78 patients (14%), and radial artery occlusion (RAO) in 55 patients (10%). Patients with RAS/RAO were more likely to be female, had smaller height and body weight, smaller body mass index and smaller body surface area (BSA) as compared with those without RAS/RAO. Multivariable logistic regression analysis identified BSA (odds ratio, 1.34 per 0.1 m2 increase; 95% confidence interval, 1.07–1.71; p = 0.01) and a history of TRA-PCI (odds ratio, 2.35; 95% confidence interval, 1.16–5.08; p = 0.017) as independent predisposing factors of radial artery injury. In a sub-analysis of 323 patients undergoing both pre-PCI RAG and follow-up RAG, pre-PCI radial diameter as well as BSA and a history of TRA-PCI were independently associated with radial artery injury. Long-term injury after TRA-PCI is considerably common and care should be paid for RAS/RAO, especially for those patients with lower BSA, history of TRA-PCI and small radial artery diameter.
Multiple attribute group decision-making based on cubic linguistic Pythagorean fuzzy sets and power Hamy mean
Authors: Xu Wuhuan , Shang Xiaopu , Wang Jun
Published: February 2021

The linguistic Pythagorean fuzzy sets (LPFSs), which employ linguistic terms to express membership and non-membership degrees, can effectively deal with decision makers’ complicated evaluation values in the process of multiple attribute group decision-making (MAGDM). To improve the ability of LPFSs in depicting fuzzy information, this paper generalized LPFSs to cubic LPFSs (CLPFSs) and studied CLPFSs-based MAGDM method. First, the definition, operational rules, comparison method and distance measure of CLPFSs are investigated. The CLPFSs fully adsorb the advantages of LPFSs and cubic fuzzy sets and hence they are suitable and flexible to depict attribute values in fuzzy and complicated decision-making environments. Second, based on the extension of power Hamy mean operator in CLPFSs, the cubic linguistic Pythagorean fuzzy power average operator, the cubic linguistic Pythagorean fuzzy power Hamy mean operator as well as their weighted forms were introduced. These aggregation operators can effectively and comprehensively aggregate attribute values in MAGDM problems. Besides, some important properties of these operators were studied. Finally, we presented a new MAGDM method based on CLPFSs and their aggregation operators. Illustrative examples and comparative analysis are provided to show the effectiveness and advantages of our proposed decision-making method.
Experimental study of the dust-removal performance of a wet scrubber
Authors: Hu Shengyong , Gao Yang , Feng Guorui , Hu Fei , Liu Changhe , Li Jihua
Published: February 2021

A variety of dust control methods are often applied in coal mines, among which the application of wet scrubbers has proven to be an efficient technology for the removal of dust in airstreams, rather than diluting or confining the dust. In this paper, a wet scrubber design was developed. Based on a self-designed experimental test platform, the total dust concentration, respirable dust concentration, air volume, and average pressure drops of wet scrubbers with 12, 16, 20, and 24 blades were measured under different water intake conditions. The results show that the different water intake levels have only minimal effects on the air volume of the wet scrubbers. However, increased water intake had improved the dust removal efficiency of the wet scrubbers with the same number of blades. The wet scrubber with 16 blades was found to have the best dust removal efficiency at a water intake level of 1.35 m3/h. Its total dust and respirable dust removal efficiency reached 96.81% and 95.59%, respectively. The air volume was 200.4 m3/min, and the average pressure drop was determined to be 169.4 Pa. In addition, when the wet scrubber with 16 blades was applied in a coal preparation plant in China’s Shanxi Province, it was observed that the total dust concentration had fallen below 8.1 mg/m3, and the respirable dust concentration had fallen below 5.9 mg/m3. Therefore, the results obtained in this research investigation provide important references for the use of wet scrubbers to improve coal production environmental conditions.
Suramin enhances the urinary excretion of VEGF-A in normoglycemic and streptozotocin-induced diabetic rats
Authors: Chyła Gabriela , Sałaga-Zaleska Kornelia , Dąbkowski Kamil , Kuchta Agnieszka , Jankowski Maciej
Published: February 2021

Background

Vascular endothelial growth factor A (VEGF-A) and P2-receptors (P2Rs) are involved in the pathogenesis of diabetic nephropathy. The processing of VEGF-A by matrix metalloproteinases (MMP) regulates its bioavailability. Since the ATP-induced release of MMP-9 is mediated by P2Rs, we investigated the effect of suramin on VEGF-A excretion in urine and the urinary activity of total MMP and MMP-9.

Methods

The effect of suramin (10 mg/kg, ip) on VEGF-A concentration in serum and its excretion in urine was investigated in streptozotocin (STZ)-induced diabetic rats over a 21-day period. The rats received suramin 7 and 14 days after a single STZ injection (65 mg/kg, ip). A 24-h collection of urine was performed on the day preceding the administration of STZ and the first administration of suramin and on the day before the end of the experiment. The VEGF-A in serum and urine, albumin in urine, and total activity of MMP and MMP-9 in urine were measured using immunoassays.

Results

Diabetic rats are characterized by a sixfold higher urinary excretion of VEGF-A. Suramin potentiates VEGF-A urinary excretion by 36% (p = 0.046) in non-diabetic and by 75% (p = 0.0322) in diabetic rats but it did not affect VEGF-A concentration in the serum of non-diabetic and diabetic rats. Urinary albumin excretion as well as total MMP and MMP-9 activity was increased in diabetic rats, but these parameters were not affected by suramin.

Conclusion

Suramin increases the urinary excretion of VEGF-A in normoglycemia and hyperglycaemia, possibly without the involvement of MMP-9. Suramin may be used as a pharmacological tool enhancing VEGF-A urinary secretion.