bluuebunny/crossref_metadata_2025 huggingface dataset:
Regenerative medicine and orthobiological drugs possibilities in upper limb diseases treatment: Literature review
Authors: Greben Anastasiya I. , Eremin Petr S. , Byalik Juliya V. , Kostromina Elena Yu. , Parsadanyan Gajk K. , Markov Pavel A. , Afanasiev Aleksei V. , Greben Tatiana N.
Published: June 2023

The analyses of regenerative medicine progress, stem cell biology, and platelet rich plasma growth factor mechanisms of action have pushed many researchers to use orthobiological drugs in their clinical practice. This review aimed to present the use of regenerative techniques and orthobiological drugs in the treatment of upper limb diseases. The open electronic database of PubMed (MEDLINE) was used in the search for scientific studies. The literature search was conducted using the keywords regenerative medicine, orthobiology, hand, wrist joint, platelet rich plasma, mesenchymal stem cells, and stromal-vascular function. The article presents the results and rationale of the use of orthobiological drugs in the treatment of various hand and upper limb pathologies. The use of orthobiological drugs and regenerative techniques in the treatment of upper limb diseases is a safe and promising direction. For the subsequent use of effective cell products, further research is needed to assess their long-term results and development of unified protocols for their use.
Las buenas prácticas en la organización de eventos antes y durante la COVID-19: análisis de los Premios Dircom Ramón del Corral, Premios Eventoplus y FIP Festival
Authors: Corbacho Valencia Juan Manuel
Published: June 2023

La celebración de festivales y premios dentro de un sector supone un reconocimiento a su actividad. Los profesionales ven reconocido su trabajo y esfuerzo, a la vez que se acaban estableciendo una serie de buenas prácticas en el sector profesional. El objetivo del presente trabajo consiste, por un lado, en presentar a los ganadores de los principales galardones del sector, así como analizar y determinar las principales pautas de éxito de los casos premiados. Se han estudiado las ediciones del 2019 y 2020 de los Premios Dircom Ramón del Corral, los Premios Eventoplus y el FIP Festival para abarcar tanto la situación prepandemia como la reacción del sector a la misma. Para ello se han analizado todos los datos disponibles tanto en las webs como en los canales oficiales de los propios premios, como de los clientes y agencias ganadoras. A ellos se sumó una búsqueda entre las principales publicaciones online del sector como PRnoticias, ReasonWhy, Ctrl Publicidad, IPMark o MarketingDirecto. Los principales resultados indican una importante tendencia a la espectacularización de los actos, principalmente de la mano de la tecnología gracias a herramientas como el video mapping o la realidad virtual, con experiencias inmersivas que queden en el recuerdo de los asistentes. Ha aumentado considerablemente el recurso a influencers y la sostenibilidad se consolida como hilo conductor de los eventos.
Aralama çalışması sonrasında elde edilen kayın odunlarının ve kupulasının odun plastik kompozit (OPK) üretiminde değerlendirilmesi
Authors: ŞAHİN Mücahit , BAŞBOĞA İbrahim Halil
Published: June 2023

Bu çalışma kapsamında aralama çalışması sonucunda yakacak odun sınıfında bulunan kayın odunlarının ve kayın kupulalarının odun plastik kompozit (OPK) üretiminde dolgu maddesi olarak değerlendirilmesinin üretilecek olan kompozitlerin teknolojik özellikleri üzerine etkilerinin belirlenmesi amaçlanmıştır. Bu amaç doğrultusunda 2 farklı dolgu maddesi kullanım oranı (%0 veya %50) ve 3 farklı tipte lignoselülozik dolgu maddesi kullanımı (%50kayın, %25kayın+%25kupula veya %50 kupula) ile polipropilen (PP) bazlı OPK üretimleri gerçekleştirilmiştir. Bunun yanı sıra 2 farklı oranda (%0 ve %3) maleik anhidrit aşılanmış polipropilen (MAPP) uyumlaştırıcı ajan olarak kullanılmış ve MAPP kullanımının etkileri incelenmiştir. Üretilen OPKların mekanik (çekme direnci, kopmada uzama, eğilme direnci, eğilmede elastikiyet modülü ve darbe direnci) ve fiziksel (yoğunluk ve sertlik) özellikleri ilgili standartlara uygun olarak belirlenmiştir. Elde edilen sonuçlar neticesinde lignoselülozik dolgu maddelerini kendi içerisinde karşılaştırıldığında kayın odun unlarının kullanımı ile en yüksek mekanik özelliklerin elde edildiği, kupula unlarının kompozit malzemelerin içerisine eklenmesi ile mekanik direnç özelliklerin negatif etkilendiği ve kupula kullanım oranının artması ile mekanik özelliklerinde negatif yönde etkilenmesinin arttığı görülmüştür. Genel olarak MAPP kullanımı üretilen OPKların mekanik özelliklerini iyileştirmiştir. Sadece kayın odun unlarının MAPP ile birlikte kullanılması ile üretilen Kompozit gruplarında kopmada uzama özelliği hariç tüm mekanik özelliklerde en yüksek değerler elde edilmiş ve kontrol grubuna nazaran belirgin artışlar gözlemlenmiştir. Çalışma neticesinde kayın odun unları ve kupula unlarının dolgu maddesi olarak kullanıldığı PP-bazlı OPK üretimleri başarılı bir şekilde gerçekleştirilmiştir. Kayın odun unların tek başına, kupulalarının ise kayın odun unları ile birlikte ve %25 oranından daha az kullanılması ile daha iyi performans yakalanacağı düşünülmektedir.
Treatment of paper recycling wastewater using microwave technology
Authors: ÖZKAN Uğur , ŞAHİN Halil Turgut
Published: June 2023

In this study, we conducted a novel method by using a household type Microwave Owen (MW) under selected operational parameters (power and time) to treat wastewater from paper recycling under laboratory conditions. We seek to evaluate changes of the MW experimental parameters, comparatively. All measured pH values were found to be in very narrow range, between pH 7.10 (BII) and pH 7.53 (DIV), in slightly alkaline range (>7.0). However, the highest Electrical Conductivity (EC) difference was found to be 46 µS/cm. The 60 seconds MW irradiated samples at four power levels (90-, 180-, 270-, 360 Watts) showed higher ORP values than control (C1: 195 mV) while the highest ORP value of 213 mV was found with sample treated 360 W and 60 seconds (DIV). It is notable that sample DIV showed the highest pH, EC, ORP and TDS value. The control sample had turbidity value of 42.5 NTU. In all MW power levels and durations, turbidity removal was apparent which MW impact on turbidity. The lowest turbidity value of 22.2 NTU was found with sample DIV which was the highest rate of turbidity removal efficiency (DIV: 86.2%). The present study revealed that MW irradiation could be used to effectively reduce the selected physicochemical parameters that may assist in the description of wastewater quality.
Evaluation of sesamol for anxiolytic activity in 72 hours sleep deprivation model in C57BL/6 mice
Authors: Singh Richa , Koare Shilpa N. , Shukla Ajay K.
Published: June 2023

Background: In our study, we explored anxiolytic activity of sesamol in C57BL/6 mice. Anxiety was induced in mice after 72 hours of sleep deprivation. Anxiety was assessed by three behavioural tests as Open field test, hole board test and light dark chamber test.
Methods: In our study, sesamol was evaluated in C57BL/6 mice for anxiolytic activity. Anxiety was induced by flower pot technique, in which sleep deprivation was done in mice for 72 hours. After 72 hours of sleep deprivation, the animals were subjected to three behavioural tests, as open field test, Hole board test and Light dark chamber test. In the Open field test, parameter assessed was time spent in central square, that was considered as a measure of anxiolytic activity. In hole board test, increase in number of head dips was indicative of anxiolytic activity. Anxiety assessment was also done by light dark chamber test, where more time spent in light chamber is considered as indicative of anxiolytic activity.
Results: In open field test, sesamol 20 mg/kg group, the time spent in central square was statistically significant (p<0.05) in post hoc comparison, suggesting that sesamol exhibited anxiolytic effect in animals. In hole board test, sesamol 20 mg/kg group showed significant increase (p<0.05) in number of head dips indicating its anxiolytic activity in the said model. In light dark chamber test, there is significant increase in anxiolytic activity in diazepam group as compared to control group, while not significant with sesamol in either dose in light dark chamber test.
Conclusions: So, to conclude, sesamol exhibited statistically significant anxiolytic activity in the dose of 20 mg/kg in open field test and hole board test.
Comparative efficacy of polyethylene glycol 3350 monotherapy against polyethylene glycol 3350 plus sodium picosulfate combined therapy in treating fecal impaction in pediatric functional constipation patients
Authors: Shinghal Utsav , Sharma Shruti , Kaundal Purshottam K.
Published: June 2023

Background: Functional constipation (FC) is a common pediatric problem worldwide. The management of FC comprises of a short initial disimpaction phase followed by long-term maintenance phase. Currently, polyethylene glycol (PEG) is considered as standard disimpaction therapy in pediatric FC patients. The aim of our study was to compare the efficacy of polyethylene glycol 3350 monotherapy with polyethylene glycol 3350 and sodium picosulfate combined therapy in treating fecal impaction in pediatric FC patients.
Methods: All children (aged >1 year) diagnosed with FC as per ROME IV criteria and presenting to the out-patient department of pediatric gastroenterology, hepatology and nutrition unit of a tertiary health centre in north Indian Himalayan state were randomized into two open label, prospective, parallel groups, namely group A (receiving PEG 3350 monotherapy) and group B (receiving combined PEG 3350 plus sodium picosulfate therapy), over a period of 13 months. The outcome was evaluated as successful disimpaction with onset of loose/watery stools (Type-7 of Bristol stool chart scale). The success rates and mean time to disimpaction for two groups were computed and compared.
Results: Eighty-one patients were randomized into two groups. The mean time to disimpaction was found to be significantly lower (p<0.001) for group B (2.37±1.16 days) when compared to group A (4.00±1.43 days). There was successful resolution of impaction in both groups.  No adverse events were reported in either group.
Conclusions: Combined PEG 3350 and sodium picosulfate therapy significantly reduces the disimpaction time when compared with PEG 3350 monotherapy in pediatric population, however both the therapies appear similar in achieving successful disimpaction.
Gasotransmitters: a review
Authors: Natarajan Anusha , G. Jefry Winner
Published: June 2023

The gaseous molecules produced endogenously with several physiological functions are called gasotransmitters. Even though initially, they were predominantly thought to be of neuronal origin, recent research has clarified that they have roles far beyond that. Their primary function is maintaining the integrity of the cardiovascular system and many other parts. From the available knowledge, we have just started to learn about their roles in physiological systems that could be translated to pharmacological drug development and therapeutics. Most of the process that remains in the form of preclinical research has to go a long way toward utilizing them in therapeutics. This review addresses the various levels at which they could be potentially exploited as therapeutics and their recent entry into clinical trials.
Effectiveness of video assisted teaching on knowledge and practice regarding suctioning of children on mechanical ventilator among nurses working in paediatric department
Authors: Sharma Anurag , S. Subin
Published: June 2023

Background: Airway secretion clearance is a normal process that is essential for preventing respiratory infections, atelectasis, pulmonary haemorrhage and maintaining airway patency. In order to ensure this, effective and safe suction is necessary. Thus, endotracheal suctioning removes secretions which gets accumulated in the endotracheal tube through using negative suction pressure. The study aimed to assess the effectiveness of video assisted teaching on knowledge and practice regarding suctioning of children on mechanical ventilator among nurses working in pediatric department.
Methods: Data were collected with the help of demographic-profile, Self-Structured knowledge questionnaire and Rating scale tool from 38 samples using Purposive sampling technique who met the inclusion criteria. The pretest data collected before intervention and post-test data collected after one week of video assisted teaching.
Results: The result revealed that post intervention knowledge score was found to be more (20.44±2.68) than pre intervention knowledge score (14.31±2.77), t=9.19. Post intervention attitude score was found to be more (26.86±3.30) than pre intervention attitude score (18.52±3.68), t=8.17 at 0.05 level of significance.
Conclusions: These findings revealed that the video assisted teaching programme on knowledge and practice was effective.
Study to assess incidence and type of congenital heart defect in children with down syndrome presenting to tertiary care teaching hospital of Southern Rajasthan
Authors: Sanadhya Anuradha , Meena Nitesh , Sharma Priya , Setia Sakshi
Published: June 2023

Background: Down syndrome occurs in people of all races and economic levels. Cardiac anomalies with a prevalence of about 50% are the most common anomaly responsible for death during the 1st two years of life in children with down syndrome. Objective of the study was to Assess the incidence and type of congenital heart disease in children with down syndrome presenting to a tertiary care hospital.
Methods: Hospital based descriptive study. Participants: All children (0 to 18 years) diagnosed (clinically or on karyotyping) with Down syndrome, presenting in RNT Medical College, Udaipur Each patient was evaluated with a pre-set Performa which contained detailed sociodemographic profile, maternal and clinical history including age of conception, detailed physical examination to look for features of down syndrome. Degree of Intellectual / Developmental retardation was assessed by Vineland Social Maturity Scale. 2D- echo, karyotyping was done in all patient. CBC, thyroid profile, CXR, USG- abdomen, Invertogram were done as per need.
Results: Total 144 participants included in the study, 75 (52%) were females and rest were males 48%. Out of these 111 (77%) were aware about dog bite causes disease and among these 52 (46.8%) were aware that dog bite causes rabies. Among the participants, 138 (95.8%) were aware about the vaccine availability and 125 (90.5%) knew vaccine is available in Government Hospital. In the study 88% of dog bite victims received treatment.
Conclusions: More than half of children with Down syndrome have congenital heart disease, mostly Acyanotic, more specifically VSD. Early screening and diagnosis re the key to avoid irreversible hemodynamic consequences.
New-born screening of metabolites with liquid chromatography-mass spectrometry and gas chromatography–mass spectrometry: a metabolic and molecular signatures methyl malonic aciduria with combined oxidative phosphorylation deficiency-10: a rare case report
Authors: Subramaniam Samu , A. T. Arasar Seeralar , Subramaniam Shyama , Chelladurai Subhasree Ramarathinam
Published: June 2023

An uncommon autosomal recessive organic acid disease is malonic aciduria. This disease may be easily identified and included in the NBS programmes by means of the widespread use of tandem mass spectrometry’s in the study of the amino acid/acylcarnitine profile using dried blood spots (DBS) for newborn screening. In Tamil Nadu, we reported the first screened and diagnosed with malonic aciduria by newborn screening (NBS) in early neonatal period. The patient possesses a malonyl-CoA decarboxylase genetic variation not previously described. This disease should be distinguished from a related malonic and methylmalonic aciduria problem. Malonic aciduria's clinical phenomenology varies and pathogenesis is not completely known. The proper treatment regimen, nutritional therapy or frequent follow-up to these individuals are not guided or recommended. The majority of current treatment data is based on a single research or case report.
Implementation of diagnostic stewardship in blood culture laboratory: a large-scale interventional study in a tertiary care hospital, South India
Authors: Rajashekar Deepashree , Dhandapani Sarumathi , Sastry Apurba Sankar
Published: June 2023

Background: Laboratories with well-established diagnostic stewardship program for culture and antimicrobial susceptibility test (C-AST) play a key role in guiding the clinicians to institute specific targeted therapy.
Methods: The study period was divided into three phases; pre-intervention phase, intervention phase and post- intervention phase. During the pre-intervention phase, the blood culture was performed by conventional methods. During the intervention phase, immense efforts were made for full-fledged implementation of all the components of intervention-educational intervention for microbiology and clinical team and automations for culture, workflow modifications for performing preliminary tests in parallel with reporting, enhanced reporting frequency and stage-wise communication of reports to the clinicians.
Results: There was a significant improvement in the isolation rate in the post-intervention phase (from 10.3% to 15.5%). There has been a steady decrease in mean turnaround time (TAT) of positive culture reports (from 85 to 45 h), which was in turn due to faster blood culture positivity, identification time and AST time. There was also significant improvement in clinical team performance on various parameters such as % of samples sent in pair, % of specimens with appropriate blood volume collected and % culture drawn before the antibiotic start.
Conclusions: Our observation shows significant improvement in the pathogen isolation rate as well as performance of both microbiology and the clinical team. Most patients with sepsis are critically ill, therefore, it is the responsibility of every clinical microbiologist to implement the highest standard of diagnostic stewardship in blood culture laboratory.
Memorias del VI Simposio Internacional en Fisiología y Nutrición Vegetal
Authors: Barriga-Medina Noelia , Pazmiño-Guevara Carlos , León-Reyes Antonio
Published: June 2023

El Colegio de Ciencias e Ingeniería, Politécnico, y la carrera de Agronomía de la Universidad San Francisco de Quito USFQ, bajo la filosofía de las Artes Liberales, y con el fin de apoyar el desarrollo del sector agrícola y agroindustrial del país organiza el VI Simposio Internacional en Fisiología y Nutrición Vegetal. El Simposio se caracteriza por la exposición de temas de interés técnico-científico, con un enfoque aplicado al manejo para la producción agrícola. En esta ocasión se abordarán los siguientes temas:• Nutrición y metabolismo• Luz y sus respuestas fisiológicas• Microbiomas vegetales• Defensas vegetalesPor su naturaleza, el evento está dirigido a profesionales del sector agrícola e investigativo, al igual que a estudiantes de las distintas instituciones vinculadas al sector. El objetivo de este tipo de evento es incentivar el interés del estudio sobre el funcionamiento de plantas, que ayuden al sector agrícola a resolver los diversos problemas prácticos usando los conocimientos de la fisiología vegetal.
Memorias del XII Congreso de Periodismo en Debate #PerDebate22
Authors: Samson Eric , Orbe Tania
Published: June 2023

En este documento se presentan las Memorias del XII Congreso de Periodismo en Debate #PerDebate22 que tuvo como eje principal la temática de Resiliencia e innovación.
Yok Olanı Yeniden Yaratmak Mümkün mü? Müteahhirûn Dönemi Kelâmında Ma‘dûmun İ‘âdesiyle İlgili Tartışmalar
Authors: YAVUZ Sercan
Published: June 2023

Kelâmcıların cismânî haşrin imkânı ve anlaşılmasını savunmak için ortaya koydukları en temel tartışmalardan biri ma‘dûmun i‘âdesi yani yok olanın aynıyla yeniden yaratılmasıdır. Birtakım farklılıklara rağmen Mu‘tezile kelâmcıları da dâhil olmak üzere ma‘dûmun i‘âdesi kelâmcılar tarafından mümkün görülmüştür. Ma‘dûmun i‘âdesini kabul etmeyerek kelâmcıların klasik görüşüne muhalefet eden İbn Sînâ, yeni bir tartışmanın ortaya çıkmasına ve i‘âde konusunda fikir ayrılıklarına neden olmuştur. Ondan sonra gelen ve ondan etkilenen İslam filozofları ve kelâmcılar, İbn Sînâ’nın yolundan gitmiş ve onun ma‘dûmun i‘âdesinin mümkün olmadığı yönündeki delillerini geliştirerek yeniden formüle etmiştir. Aynı şekilde ma‘dûmun i‘âde imkânını klasik görüşü destekler mahiyette savunan müteahhirûn dönemi kelâmcıları yeniden inşa edilen bu delillere yönelik yeni eleştiriler getirmişlerdir. Böylece tartışma ma‘dûmun i‘âdesinin mümkün olup olmadığı konusunda İslam filozofları ve kelâmcılar arasında gerçekleşen bir meseleye dönüşmüştür. Hatta öyle ki kelâmcılara göre diriliş tartışmalarının bir uzantısı olan ma‘dûmun i‘âdesi konusuna sem‘iyyât bahislerinin alt başlıklarında yer veren kelâmcıların aksine İslâm filozofları, ma‘dûmun i‘âdesini mümkün görmediklerinden metafizik tartışmaların yer verildiği umûr-ı âmme bahislerinin varlık ve yoklukla ilgili alt başlıklarında ele almayı tercih etmişlerdir. Çünkü İbn Sînâ’nın önayak olduğu görüşe göre ma‘dûmun i‘âdesi yoklukla ilgili olan metafizik bir meseledir. Bir tarafta ma‘dûmun i‘âdesini mümkün görmeyen filozoflar, var olup daha sonra yok olan şeylerin aynıyla yeniden yaratılamayacağını yeni argümanlarla savunurken diğer tarafta kelâmcılar cedelî bir üslupla hem bu argümanlara yönelik eleştirilerini sunmuşlar hem de yok olanların tekrar aynıyla yeniden yaratılacağını savunmaya çalışmışlardır. Dolayısıyla bahsi geçen bu tartışmaları eserlerine taşıyan kelâmcılar, makalemizin başlığı olan ma‘dûmu yeniden yaratmak mümkün mü sorusuna cevap aramışlardır. Zira metinlerin içeriği ma‘dûmun i‘âdesini red ve kabul edenlerin kimler olduğu, felsefeci ve kelâmcılar arasındaki tartışmanın arka planı ve bağlamı, i‘âdenin reddi için ileri sürülen istidlâlî deliller, bu delillere yönelik cevap niteliğindeki eleştiriler ve i‘âdenin kabulü için ileri sürülen deliller hakkında tartışmanın seyrine dair detaylı ve önemli bilgiler sunmuştur. Bu bağlamda çalışma, kelâmcı ve felsefeciler arasında tartışma konusu haline gelen ma‘dûmun i‘âdesi yani ma‘dûmun yeniden aynıyla yaratılıp yaratılmayacağı hakkındaki ileri sürülen delilleri ve bu delillere yönelik eleştirileri ele almıştır. İ‘âdenin mümkün görülmemesine yönelik delillerin kaynağının İbn Sînâ’ya dayanmasından dolayı ona da işaret edilmiştir. Kapsam olarak ise çalışmada müteahhirûn dönemi kelâmının öne çıkan kelâmcılarının temel eserleri ve bu eserlere yazılan temel şerhler esas alınmıştır.
MODEL OF TEACHING FOREIGN STUDENTS FOR THE PERCEPTION OF FICTION MEANINGS WITH THE USE OF EDUCATIONAL FICTION HYPERTEXT
Authors: Miller Ludmila V. , Fedotova Nina L.
Published: June 2023

The relevance of the study is due to the fact that in recent years human relation with information flows have changed. The thinking and perception of meanings, especially by the younger generation, also begin to change noticeably. In this regard, the communication of an individual with a literary text presented in digital format deserves more attention. The purpose of the study is to create a model of learning to read this type of text, taking into account the features of a literary hypertext, which will optimize the process of learning to read a literary text in a foreign language. As an example of methodical processing of an autonomous educational hypertext, an excerpt from the story "Scar" by E. Grishkovets was used. In the process of developing a model for teaching foreigners to read literary hypertext, the following methods were used: analytical (linguocultural and linguocognitive analysis), interpretation method and modeling. In the study were compared such concepts as “literary text”, “hypertext”, “electronic hypertext” and “educational fiction text”. Literary hypertext is a traditional text, but it is organized in a different way than a linear text, so when it is perceived, specific perception mechanisms operate. The definition of educational literary hypertext in the aspect of teaching Russian as a foreign language is given; the linguodidactic potential of hypertext in relation to the teaching of Russian as a foreign language is revealed, the algorithm for working with Russian-language literary hypertext in a foreign audience is substantiated. It is assumed that educational hypertext as a new way of artistic communication can exist in two forms: network hypertext and autonomous hypertext. It is concluded that a methodically processed literary text, presented as a hypertext, makes it possible to optimize the process of teaching foreign students to read literary works in Russian. The prospects for the study are seen in the creation of an electronic manual for teaching foreign students to read the works of Russian writers based on the proposed model.
FEATURES OF USING DISTANCE LEARNING TECHNOLOGIES IN TEACHING FOREIGN LANGUAGES AT UNIVERSITY: ANALYSIS OF EXPERIENCE
Authors: Proskura Yana V.
Published: June 2023

A lot of attention is paid to distance learning today, as, probably, none of the many ways of learning using technology. Modern research in education, and in particular in ICT, tends to use technological resources to the maximum and use them effectively in pedagogy. In the field of foreign language teaching, much has been done to cover various languages of the world, but attempts are constantly being made to find new solutions, taking into account the specific needs of language learners. The purpose of the article is to present the technological aspect of the DE system common to all courses, to identify the main features of teaching a foreign language in distance learning, to consider the process of developing and implementing online English courses from the point of view of the overall design of the course, the choice of teaching materials, technological and pedagogical processing of course materials, the role of the teacher, support and motivation of students.
A. CHEKHOV AND V. KAVERIN: THE TWO MONTIGOMOS
Authors: Lisitsa Alla R.
Published: June 2023

The present article covers the results of the comparative analysis of the short story "Boys" by A. Chekhov and "The Two Captains" by V. Kaverin whose protagonists both go by the same symbolic name Montigomo the Hawk Pounce. Similar treaits in the images of Chechevitsyn and Sanya Grigoriyev are singled out, similar for the two works motifs of escaping and reading are highlighted, quotational allusions are located. Despite the fact that the appearance of Montigomo in Chekhov's text is traditionally attributed to the historical realia (the writer's contemporary had a quite similar nickname), the article suggests to look for possible prototypes of that name's in the classical adventure literature. The author suggests that the typological similarities between the texts are rooted not only in the reception of the Native American novels in the 19th-century Russia but also by the style of A. Chekhov influencing the formation of V. Kaverin's artistic principles that are emphatically oriented to the literary tradition.
Brain Targeted Drug Delivery System: A Review
Authors: Saxena Somesh , Shabber  , Bhardwaj Sudeep , Aggarwal Ashutosh
Published: June 2023

Brain is the most sophisticated and important organ of our body. Together with spinal cord it control all actions, all functions voluntary or involuntary and plays a vital role in managing various organ systems of our body. It has its own protective barriers that protects the brain from various pathogens and toxins that may cause the harm. These barriers are namely Blood-Brain barrier and Blood-Cerebrospinal Fluid Barrier. The highly lipophilic nature of these barriers helps them in protecting the brain, allowing the passage of only highly lipophilic drugs to the brain through blood. However when there is an infection or injury in brain, the same barriers pose a hindrance in the delivery of drugs to the brain for treatment. Usually, drugs are usually hydrophilic in nature and since barriers of brain are lipophilic in nature, the finds it hard to cross these barriers and reach the brain. In order to overcome the problem in drug delivery to the brain as a target organ various drug delivery techniques were developed. Invasive and non-invasive approaches are two main approaches that are used to deliver drug to brain. In invasive approach the permeability of BBB is decreased or the drug is directly administered, whereas in non-invasive approach the drug molecule is altered to enhance its lipophilicity allowing its passage to the brain. This review aims to describe the various brain targeted drug delivery system..
Apontamentos sobre influências filosóficas em escritos de André Vidal de Araujo
Authors: Moreira Jeidson Eduardo Mendes , Andrade Aldair Oliveira de
Published: June 2023

Este trabalho busca a partir da leitura de alguns escritos de André Vidal de Araújo, deslindar suas possíveis influências filosóficas. A metodologia  utilizada  para sua realização foi a revisão bibliográfica de textos do autor que versassem sobre o seu pensamento social, buscando-se identificar nesses os pensadores que influenciaram direta ou indiretamente suas propostas para a questão social na Amazônia brasileira. Assim, podemos concluir, que os textos analisados não deixam dúvidas quanto o conhecimento do autor de diversas áreas das ciências humanas, ao mesmo tempo, é inegável que o autor se debruçou significativamente para construção de suas propostas em filosóficos, seja para refutá-los o mesmo para sustentar seus argumentos.
La juventud y la ley en Colombia: la ciudadanía juvenil en el contexto de la democracia digital
Authors: Cuartas Giraldo María Isabel , Acevedo Arango Óscar Fernando , Arias Ramírez Diego Alonso , Quiroz Cañizares Jorge Andrés
Published: June 2023

El ejercicio de la ciudadanía juvenil en Colombia implica la participación de la juventud en la toma de decisiones públicas. Este artículo presenta el proceso y los resultados de un programa piloto sobre formación de competencias jurídicas, políticas y éticas en jóvenes de Marinilla, Antioquia, para el ejercicio de la ciudadanía juvenil en espacios reales y virtuales, en el contexto de la pandemia de covid-19, desde los marcos del Estatuto de Ciudadanía Juvenil y la Política Pública de Gobierno Digital. Se implementó un modelo multimetodológico de investigación-acción digital: Metodología de Marco Lógico (MML), Tecnologías para el Empoderamiento y la Participación (TEP), Acción Digital e Incidencia Política Local (Adiplo). En el curso, en modalidad virtual, participaron 20 jóvenes. Como resultado se obtuvo la cualificación y el aporte a la formación de la candidatura y elección de cinco de los participantes como consejeros municipales de la juventud de Marinilla, además de la evaluación participativa de las y los jóvenes acerca de la política pública de juventud.
The Motives for Issuing Exchangeable Bonds in the Privatization of State‑Owned Enterprises
Authors: Kaźmierczak Damian
Published: June 2023

Using a unique sample of exchangeable bond issues carried out in seven countries since the 2000s, this paper investigates the role of hybrid debt in the privatization of state‑owned enterprises (SOEs) via government‑controlled investment vehicles. This research shows that so far, sixteen series of exchangeable bonds amounting to approx. USD 25 billion were issued to privatize ten SOEs in the telecommunication, energy, basic materials, industrials, healthcare, and utilities sectors in Europe and Asia. Moreover, in some cases, the privatization of SOEs by means of exchangeables can prove to be a more favorable alternative to traditional methods of selling shares directly on the capital market, for example, via IPOs or SPOs (during periods of deep undervaluation of privatized companies or of high stock market volatility). First, shares can be sold at a later date and at a higher price. Second, the impact on the stock market price of an SOE may be less disruptive to shareholders. Third, the entire privatization process tends to be more flexible for issuers in that they can perceive exchangeables as a source of relatively cheap, long‑term external capital while keeping control over the privatized company until the potential conversion of debt by bondholders.
Innovative Clusters of Global Trade Leadership
Authors: Tsymbal Liudmyla , Moskalyuk Nataliya , Gromenkova Svitlana , Chaban Vitalii
Published: June 2023

The formation of a new global system and systemic global interdependence has generated new competitiveness factors for market participants, determining their appropriate strategic behavior to ensure a highly competitive position and leadership. Therefore, the purpose of the study is to identify the countries of intellectual leaders in the global market and the factors that influence the positions that countries achieve in terms of leadership. The following research methods were used: multifactor regression models, cluster analysis, and comparative analysis. Based on the authors’ methodology for assessing countries’ intellectual leadership, the clustering of countries in the global economy is determined. The evaluation algorithm was based on three levels: 1) resources, 2) the intermediate results of intellectual activity, and 3) the final results of overall progress. Using a multifactor regression model and cluster analysis, four clusters of countries were identified according to key indicators of intellectual leadership. For each cluster, the specialization of the two countries in terms of merchandise exports was analyzed: cluster 1 – the United States and Germany; cluster 2 – Israel and Italy; cluster 3 – Brazil and Ukraine; cluster 4 – China and South Korea. Each country is assigned an index of economic complexity, and the change in position of each country within a cluster over ten years is noted. An important goal is to understand the determinants of the leadership of countries in each geographic region. The analysis is based on the cluster analysis carried out in previous publications. The clustering of countries was carried out based on the dynamics of macroeconomic indicators over the past 15 years.
Environmental Quality, Infant Morality, and Economic Growth in Selected Sub‑Saharan African Countries
Authors: Aderounmu Busayo , Awofiranye Adedoyin , Oni Olubusayo Emmanuel
Published: June 2023

Beyond the usual macroeconomic stability, which is a necessity for economic growth, more focus should be placed on the effects that environmental quality has on infant mortality in sub‑Saharan Africa. Africa has always had the highest rate of infant mortality and the poorest environmental quality in the world. High infant mortality shows that there are unmet human needs and unenforced policies to protect the environment. Therefore, this research examines the impact of environmental quality on infant mortality and how environmental quality and infant mortality also affect economic growth using 15 selected sub‑Saharan African countries for a period of 10 years (2010–2019). The study employed fixed and random effects methods of estimation. The results showed that environmental quality has a significant negative (51.53%) impact on infant mortality and that economic growth also has a negative (45.58%) impact on infant mortality. The study recommends that governments should increase expenditure on health, with more focus on financing infant healthcare, because it also affects economic growth.
Luigi Alva : el almaviva de La Scala
Authors: Farret Georges
Published: June 2023

Estimado lector, Ahora que estás por leer las páginas de este volumen en el que se narra mi larga y afortunada actividad artística, es mi deseo dirigir mi pensamiento a Georges Farret, autor de la obra. Gracias a su obstinado e insistente deseo y, por otra parte, a su indiscutible capacidad, que incluso venció mi oposición inicial de publicar esta obra, ha sido posible dar vida a estas páginas. En este momento, pido que me acompañes recordando la dedicación y afán que puso Georges, a quien el destino le negó la oportunidad de leer su obra ya terminada. Lo recuerdo con gran admiración e invariable estima personal. ¡Gracias, Georges! -- Luis Alva Talledo
Etika praktis Ibn Muqaffa’: Kedudukan akal sehat untuk transformasi etika pada Kitab Al-Adab al-Shagir wa al-Adab al-Kabir
Authors: Mahpur Mohammad , Hasanah Mamlu’atul , Ahmad Ghozi , Kholil Akhmad
Published: June 2023

Abstract: Literary ethical literacy can be a potential for developing critical ethical awareness learned from literary arts activities. This study explores the inspiration of practical ethics developed by Ibn Muqaffa 'in the book Al-Adab al-Shagir wa al-Adab al-Kabir with literary characteristics. This research was conducted using the text analysis method on only one work of Al-Adab al-Shagir wa al-Adab al-Kabir with the stages of text collection, reading intact, selecting main sentences, finding keywords, and interpreting to contextualize ethical concepts. The results found that Ibn Muqaffa' encouraged that ethics could be accommodated using literary narratives. Ethics is subjective and relevant to the need for existential happiness that produces theological views, schools, and schools of thought. Critical reasoning is in line with literary constructions with the role of active sagacity in practical ethics. The implication is that Ibn Muqaffa's literature can inspire the development of ethical learning methods using literary narrative learning to increase the quality of life that is meaningful for everyone.Abstrak: Literasi etik sastrawi dapat menjadi potensi tumbuhnya kesadaran kritis etik yang dapat dipelajari dari kegiatan seni kesastraan. Penelitian ini bertujuan menggali transformasi etika praktis yang dikembangkan Ibnu Muqaffa’ di kitab Al-Adab al-Shagir wa al-Adab al-Kabir berciri sastra. Penelitian ini dilakukan dengan menggunakan metode analisis teks hanya pada satu karya Al-Adab al-Shagir wa al-Adab al-Kabir dengan tahap koleksi teks, pembacaan utuh, memilih kalimat utama, menemukan kata kunci, dan melakukan interpretasi untuk kontekstualisasi konsep etik. Hasil penelitian ditemukan bahwa Ibnu Muqaffa’ mendorong bahwa etika praktis dapat diwadahi menggunakan narasi sastrawi; etika praktis bersifat subyektif dan relevan dengan kebutuhan kebahagiaan eksistensial yang melahirkan pandangan, aliran, mazhab teologis; penalaran kritis sejalan dengan peran akal sehat aktif dalam etika praktis. Implikasinya, sastra Ibnu Muqaffa’ dapat mengilhami pengembangan metode pembelajaran etika secara praktis dengan menggunakan pembelajaran naratif sastrawi untuk menambah kualitas hidup yang bermakna bagi semua orang.
Improving Telenursing Skills Through Simulation-Based Education
Authors: Parmeter Sandra , Foronda Cynthia , Lee Jiye
Published: June 2023

Background:Preparing graduate-level nurses to provide care via telehealth could both increase access to care and decrease healthcare costs. However, many nursing schools do not provide telehealth experiences, especially at the graduate level.Objective:The aim of this project is to incorporate telehealth simulations in the doctor of nursing practice (DNP) curriculum at the University of Miami School of Nursing and Health Studies.Methods:This quality improvement project used a posttest-only design. The Ottawa Model of Research Use guided the project. DNP students completed a peer-to-peer telehealth simulation scenario via Zoom.Results:DNP students demonstrated confidence with an average score of 2.875 out of 3. DNP students’ teaching performance scores were 2.7 out of 3. DNP students demonstrated effective overall telehealth performance with a mean score of 13.74 out of 15.Conclusion:DNP students may benefit from increased opportunities to practice telehealth, including the use of peer-to-peer simulation, to be aptly prepared for contemporary nursing practice.
Mental Accounting and Savings Behavior: Evidence From Machine Learning Method
Authors: Zainal Alam Muhammad Aizat , Chen Yong Chen , Mansor Norma
Published: June 2023

This article proposes a machine-learning-based method that can predict individuals’ savings behavior in the presence of mental accounting. The proposed predictive model perceives wealth and consumption as each being divided into three nonfungible distinct classes, as posited by the mental accounting theory. The predictive model found that mental accounting categories do have predictive power on savings behavior where expenditure on discretionary items and current income are most important. Savings behavior is best predicted by the random forest model based on the Malaysia Ageing and Retirement Survey data.
Urgensi dan Optimalisasi Peran Dewan Pengawas Syariah (DPS) dalam Aktivitas Pasar Modal Syariah di Indonesia
Authors: Fitrianingsih Siti Erlania , Iwan Setiawan
Published: June 2023

Perkembangan dunia investasi dalam masyarakat Indonesia semakin meningkat salah satu bentuk investasi yang banyak digunakan yaitu berinvestasi pada Pasar Modal syariah. Salah satu elemen penting dalam pelaksanaan kegiatan pasar modal syariah adanya peran Dewan Pengawas Syariah (DPS) yang memiliki peran utama untuk mengawasi kepatuhan syariah. Metode yang digunakan dalam tulisan ini merupakan jenis penelitian hukum normatif dengan menggunakan pendekatan perundang-undangan. Tujuan dari penulisan ini mengupas kembali akan urgensi serta optimalisasi peran dan tugas DPS dalam melakukan pengwasan terhadap aktivitas pasar modal syariah. Sebenarnya peran DPS telah dirinci dalam peraturan Otoritas Jasa Keuangan (OJK) selaku regulator pada pasar modal syariah. Namun demikian semestinya Indonesia sudah memiliki undang-undang khusus menangani pasar modal syariah karena aturan yang diberlakukan saat ini masih berdasakan pasar modal dengan sistem konvensional yang tentunya berbeda dengan sistem syariah, aturan yang ada saat ini sudah tidak relevan dan tidak dapat mengimbangi perkembangan pasar modal syariah yang telah begitu pesat dan diminati masyarakat muslim khususnya. (The development of the world of investment in Indonesian society is increasing, one form of investment that is widely used is investing in the Islamic Capital Market. One of the important elements in the implementation of Islamic capital market activities is the role of the Sharia Supervisory Board (DPS), which has the main role of overseeing sharia compliance. The method used in this paper is a type of normative legal research using an approach. The purpose of this paper is to review the urgency and optimize the role and duties of DPS in supervising Islamic capital market activities. Actually, the role of DPS has been detailed in the regulations of the Financial Services Authority (OJK) as a regulator of the Islamic capital market. However, Indonesia should already have a special law dealing with the Islamic capital market because the current regulations are still based on the conventional capital market system which is certainly different from the Islamic system, the current regulations are no longer relevant and cannot keep pace with the development of the Islamic capital market. which has been so rapid and in demand by the Muslim community in particular)
Depopulation in the regions of Russia: results for 1992–2022 and components
Authors: Rybakovsky Oleg
Published: June 2023

The article presents the results of the author’s regularly conducted general analysis of depopulation in the regions of Russia in the post-Soviet period. The results of population reproduction for the period from the beginning of 1992 to the end of 2022 are summed up. For all regions, a ranking was carried out according to the relative level of depopulation for the period, that is, by the share of population losses due to natural decline relative to the population at the beginning of depopulation in the country (1992). For each of the selected groups of territories, the contribution of structural and non-structural components of fertility and mortality to the formation of the final natural decline of a particular region is indicated. Similarly, those few territories of Russia in which there was no depopulation for 31 years (in total) were investigated. The role of demographic structural waves in the formation of the current scale of depopulation in most of the country’s territories is emphasized. It is concluded that the depopulation is not only the result of a low fertility and high mortality of the population of the regions of Russia, but also a consequence of the negative age structure of the population, and in some periods of time — and the downward demographic structural wave. To get out of the depopulation, the demographic policy should be carried out differentially in time and territorially. The active phase of the pronatalist demographic policy should begin at the descent of the demographic structural wave, and not on the rise, as it has already happened in the history of Russia twice since 1980, which only increased the wave-like age structure of the country’s population.
Unemployment of parents — one of the poverty causes in families with children
Authors: Korchagina Irina , Prokofieva Lidia
Published: June 2023

Families with children in Russia are at high risk of poverty. The economic consequences of the coronavirus pandemic and the sanctions imposed in spring 2022 make social policy a priority. It is necessary to pay a stronger attention to groups of population at higher risk of poverty. In recent years the support for families with children has been strengthened and the circle of potential recipients of assistance expanded (raising the age of children, lifting restrictions on the type of family). Additional support measures provided to families with children to reduce the negative effects of the crisis helped to alleviate the severity of poverty but did not change the position of families with children on the welfare scale, they are still the largest group of the poor (according to Rosstat they make 80% of all poor households). It seems important to identify the main factors of poverty of families with children, which include, not least, the limited employment of parents. The main purpose of the study is to show, using the data of the statistical survey (HBS-2019), the scale of unemployment and its impact on families with children as well as gender characteristics of the phenomenon of unemployment. Financial assistance to families with children should be combined with work to activate the actions of families for self-sufficiency.
Initiative budgeting as a mechanism for raising the quality of life of the population
Authors: Frolova Elena , Rogach Olga , Razov Pavel
Published: June 2023

The sufficiency of social infrastructure facilities and their effective functioning in a particular area is one of the conditions for improving the quality of life of the population. The financial insufficiency of regional and local budgets actualizes the search for new tools to raise funds for the development of territorial infrastructure that ensures creation of decent living conditions for the population. One of these tools is mechanism of initiative budgeting. The results of the study showed a contradiction between the recognition of the undoubted advantages of this mechanism (solving acute territorial problems, leverage on the authorities, creating a platform for dialogue) in the assessments of the population and the lack of readiness of residents to be included in new financial initiatives. The key limitations to the implementation of initiative budgeting projects are the following: lack of information support, low level of awareness of residents about the problems of territorial development, distancing from local self-government practices. The results of the study showed that the majority of respondents are ready to get involved in solving the socio-economic problems of the territory if they affect the personal interests of individuals. Under the current conditions, it seems necessary to improve information and communication activities aimed at popularizing the mechanism of initiative budgeting, building social cohesion of local communities, developing the territorial identity of citizens, integrating the efforts of the authorities and the population in solving socially significant problems of the territory.