bluuebunny/crossref_metadata_2025 huggingface dataset:
Synthesis and Preliminary Biological Evaluations of Fluorescent or 149Promethium Labeled Trastuzumab-Polyethylenimine
Authors: Fitzsimmons Jonathan , Nayak Tapan , Cutler Cathy , Atcher Robert
Published: December 2015

Background: Radioimmunotherapy utilize a targeting antibody coupled to a therapeutic isotope to target and treat a tumor or disease. In this study we examine the synthesis and cell binding of a polymer scaffold containing a radiotherapeutic isotope and a targeting antibody. Methods: The multistep synthesis of a fluorescent or 149Promethium-labeled Trastuzumab-polyethyleneimine (PEI), Trastuzumab, or PEI is described. In vitro uptake, internalization and/or the binding affinity to the Her2/neu expressing human breast adenocarcinoma SKBr3 cells was investigated with the labeled compounds. Results: Fluorescent-labeled Trastuzumab-PEI was internalized more into cells at 2 and 18 h than fluorescent-labeled Trastuzumab or PEI. The fluorescent-labeled Trastuzumab was concentrated on the cell surface at 2 and 18 h and the labeled PEI had minimal uptake. DOTA-PEI was prepared and contained an average of 16 chelates per PEI; the compound was radio-labeled with 149Promethium and conjugated to Trastuzumab. The purified 149Pm-DOTA-PEI-Trastuzumab had a radiochemical purity of 96.7% and a specific activity of 0.118 TBq/g. The compound demonstrated a dissociation constant for the Her2/neu receptor of 20.30 ± 6.91 nM. Conclusion: The results indicate the DOTA-PEI-Trastuzumab compound has potential as a targeted therapeutic carrier, and future in vivo studies should be performed.
Hydrogenation of Levulinic Acid over Nickel Catalysts Supported on Aluminum Oxide to Prepare γ-Valerolactone
Authors: Fu Jie , Sheng Dong , Lu Xiuyang
Published: December 2015

Four types of nickel catalysts supported on aluminum oxide (Ni/Al2O3) with different nickel loadings were synthesized using the co-precipitation method and were used for the hydrogenation of levulinic acid (LA) to prepare γ-valerolactone (GVL). The synthesized Ni/Al2O3 catalysts exhibited excellent catalytic activity in dioxane, and the activity of the catalysts was excellent even after being used four times in dioxane. The catalytic activity in dioxane as a solvent was found to be superior to the activity in water. Nitrogen physisorption, X-ray diffraction, and transmission electron microscopy were employed to characterize the fresh and used catalysts. The effects of the nickel loading, temperature, hydrogen pressure, and substrate/catalyst ratio on the catalytic activity were investigated.
The ‘Lifeblood’ of Science and Its Politics: Interrogating Epistemic Curiosity as an Educational Aim
Authors: Papastephanou Marianna
Published: December 2015

Social- and virtue-epistemologies connect intellectual and moral concerns in ways significant for education and its theory. For most educationists, epistemic and ethical virtues are no longer dissociated. However, many political framings or operations of epistemic virtues and vices remain neglected in educational discourses. This article illustrates why a politicization of epistemic issues is relevant to education through reference to political performances of a curiosity typically considered educationally valuable. Curiosity bore political connotations from antiquity to late modernity whose exploration may add critical nuance to educational-philosophical conceptions of epistemic desire. This leads us to the main argument of the article, which is that such politicization helps us interrogate unqualified, uniform, and glorifying treatments of curiosity as an educational aim.
Pharmacotherapy Treatment Options for Insomnia: A Primer for Clinicians
Authors: Asnis Gregory , Thomas Manju , Henderson Margaret
Published: December 2015

Insomnia is a prevalent disorder with deleterious effects such as decreased quality of life, and a predisposition to a number of psychiatric disorders. Fortunately, numerous approved hypnotic treatments are available. This report reviews the state of the art of pharmacotherapy with a reference to cognitive behavioral therapy for insomnia (CBT-I) as well. It provides the clinician with a guide to all the Food and Drug Administration (FDA) approved hypnotics (benzodiazepines, nonbenzodiazepines, ramelteon, low dose sinequan, and suvorexant) including potential side effects. Frequently, chronic insomnia lasts longer than 2 years. Cognizant of this and as a result of longer-term studies, the FDA has approved all hypnotics since 2005 without restricting the duration of use. Our manuscript also reviews off-label hypnotics (sedating antidepressants, atypical antipsychotics, anticonvulsants and antihistamines) which in reality, are more often prescribed than approved hypnotics. The choice of which hypnotic to choose is discussed partially being based on which segment of sleep is disturbed and whether co-morbid illnesses exist. Lastly, we discuss recent label changes required by the FDA inserting a warning about “sleep-related complex behaviors”, e.g., sleep-driving for all hypnotics. In addition, we discuss FDA mandated dose reductions for most zolpidem preparations in women due to high zolpidem levels in the morning hours potentially causing daytime carry-over effects.
Specific Metabolites in a Phaeodactylum tricornutum Strain Isolated from Western Norwegian Fjord Water
Authors: Prestegard Siv , Erga Svein , Steinrücken Pia , Mjøs Svein , Knutsen Gjert , Rohloff Jens
Published: December 2015

We have searched for special characteristics in growth, protein expression, fatty acids and volatile organic compounds (VOCs) in a local Phaeodactylum tricornutum Bohlin strain (Bergen Marine Biobank), by comparing it with a common accession strain (CCAP). Differences in growth and expressed proteins were detected between the BMB strain and the CCAP strain, and the BMB strain reached the highest cell densities under the given growth conditions. Fatty acid (FA) analyses showed highest relative eicosapentaenoic acid (EPA) levels in the exponential phase (25.73% and 28.31%), and highest levels of palmitoleic acid (16:1 n-7) in the stationary phase (46.36% and 43.66%) in the BMB and CCAP strain, respectively. The most striking finding of the VOCs analyses was the relatively high levels of ectocarpene, 6-((1E)-butenyl)-1,4-cycloheptadiene, hormosirene, and desmarestene and structurally related compounds, which were exclusively detected in the BMB strain. Many of the VOCs detected in the CCAP and, in particular, in the BMB strain have been reported as antimicrobial agents. We suggest that the array of pheromones and antimicrobial substances could be part of an allelopathic strategy of the BMB strain, dominated by oval cells, thus reflecting the benthic life stage of this morphological form. These findings show the potential for bioactive metabolites in the BMB strain.
The Effect of Microporous Polymeric Support Modification on Surface and Gas Transport Properties of Supported Ionic Liquid Membranes
Authors: Akhmetshina Alsu , Davletbaeva Ilsiya , Grebenschikova Ekaterina , Sazanova Tatyana , Petukhov Anton , Atlaskin Artem , Razov Evgeny , Zaripov Ilnaz , Martins Carla , Neves Luísa , Vorotyntsev Ilya
Published: December 2015

Microporous polymers based on anionic macroinitiator and toluene 2,4-diisocyanate were used as a support for 1-butyl-3-methylimidazolium hexafluorophosphate ([bmim][PF6]) and 1-ethyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide ([emim][Tf2N]) immobilization. The polymeric support was modified by using silica particles associated in oligomeric media, and the influence of the modifier used on the polymeric structure was studied. The supported ionic liquid membranes (SILMs) were tested for He, N2, NH3, H2S, and CO2 gas separation and ideal selectivities were calculated. The high values of ideal selectivity for ammonia-based systems with permanent gases were observed on polymer matrixes immobilized with [bmim][PF6] and [emim][Tf2N]. The modification of SILMs by nanosize silica particles leads to an increase of NH3 separation relatively to CO2 or H2S.
Particulate Blood Analogues Reproducing the Erythrocytes Cell-Free Layer in a Microfluidic Device Containing a Hyperbolic Contraction
Authors: Calejo Joana , Pinho Diana , Galindo-Rosales Francisco , Lima Rui , Campo-Deaño Laura
Published: December 2015

The interest in the development of blood analogues has been increasing recently as a consequence of the increment in the number of experimental hemodynamic studies and the difficulties associated with the manipulation of real blood in vitro because of ethical, economical or hazardous issues. Although one-phase Newtonian and non-Newtonian blood analogues can be found in the literature, there are very few studies related to the use of particulate solutions in which the particles mimic the behaviour of the red blood cells (RBCs) or erythrocytes. One of the most relevant effects related with the behaviour of the erythrocytes is a cell free layer (CFL) formation, which consists in the migration of the RBCs towards the center of the vessel forming a cell depleted plasma region near the vessel walls, which is known to happen in in vitro microcirculatory environments. Recent studies have shown that the CFL enhancement is possible with an insertion of contraction and expansion region in a straight microchannel. These effects are useful for cell manipulation or sorting in lab-on-chip studies. In this experimental study we present particulate Newtonian and non-Newtonian solutions which resulted in a rheological blood analogue able to form a CFL, downstream of a microfluidic hyperbolic contraction, in a similar way of the one formed by healthy RBCs.
Synthesis of Bioconjugate Sesterterpenoids with Phospholipids and Polyunsaturated Fatty Acids
Authors: Gil-Mesón Ana , Roncero Alejandro , Tobal Ignacio , Basabe Pilar , Díez David , Mollinedo Faustino , Marcos Isidro
Published: December 2015

A series of sesterterpenoid bioconjugates with phospholipids and polyunsaturated fatty acids (PUFAs) have been synthesized for biological activity testing as antiproliferative agents in several cancer cell lines. Different substitution analogues of the original lipidic ether edelfosine (1-O-octadecyl-2-O-methyl-rac-glycero-3-phosphocholine) are obtained varying the sesterterpenoid in position 1 or 2 of the glycerol or a phosphocholine or PUFA unit in position 3. Simple bioconjugates of sesterterpenoids and eicosapentaenoic acid (EPA) have been obtained too. All synthetic derivatives were tested against the human tumour cell lines HeLa (cervix) and MCF-7 (breast). Some compounds showed good IC50 (0.3 and 0.2 μM) values against these cell lines.
The Activity of Cotinus coggygria Scop. Leaves on Staphylococcus aureus Strains in Planktonic and Biofilm Growth Forms
Authors: Rendeková Katarína , Fialová Silvia , Jánošová Lucia , Mučaji Pavel , Slobodníková Lívia
Published: December 2015

The purpose of this study was to detect the effectiveness of Cotinus coggygria Scop. leaves methanol extract against planktonic and biofilm growth forms of Staphylococcus aureus. The antimicrobial activity was determined by the broth microdilution test. Minimal inhibitory concentrations and minimal bactericidal concentrations were detected against two collection and ten clinical S. aureus strains. Anti-biofilm activity of the tested extract was detected using 24 h bacterial biofilm on the surface of microtiter plate wells. The biofilm inhibitory activity was evaluated visually after 24 h interaction of extract with biofilm, and the eradicating activity by a regrowth method. The tested extract showed bactericidal activity against all S. aureus strains (methicillin susceptible or methicillin resistant) in concentrations ranging from 0.313 to 0.625 mg·mL−1. Biofilm inhibitory concentrations were 10-times higher and biofilm eradicating concentrations 100-times higher (8 and 32 mg·mL−1, respectively). The phytochemical analysis of C. coggygria leaves 60% methanol extract performed by LC-DAD-MS/MS revealed quercetin rhamnoside, methyl gallate, and methyl trigallate as main constituents. Results of our study indicate that C. coggygria, rich in tannins and flavonoids, seems to be a prospective topical antibacterial agent with anti-biofilm activity.
Typology of Options for Metal Recycling: Australia’s Perspective
Authors: Golev Artem , Corder Glen
Published: December 2015

While Australia has traditionally relied on obtaining metals from primary sources (namely mined natural resources), there is significant potential to recover metals from end-of-life-products and industrial waste. Although any metals recycling value chain requires a feasible technology at its core, many other non-technical factors are key links in the chain, which can compromise the overall viability to recycle a commodity and/or product. The “Wealth from Waste” Cluster project funded by the Commonwealth Scientific Industrial Research Organisation (CSIRO) Flagship Collaboration Fund and partner universities is focusing on identifying viable options to “mine” metals contained in discarded urban infrastructure, manufactured products and consumer goods. A key aspect of this research is to understand the critical non-technical barriers and system opportunities to enhance rates of metals recycling in Australia. Work to date has estimated the mass and current worth of metals in above ground resources. Using these outcomes as a basis, a typology for different options for (metal) reuse and recycling has been developed to classify the common features, which is presented in this article. In addition, the authors investigate the barriers and enablers in the recycling value chain, and propose a set of requirements for a feasible pathway to close the material loop for metals in Australia.
Determination of Gonyautoxin-4 in Echinoderms and Gastropod Matrices by Conversion to Neosaxitoxin Using 2-Mercaptoethanol and Post-Column Oxidation Liquid Chromatography with Fluorescence Detection
Authors: Silva Marisa , Rey Verónica , Botana Ana , Vasconcelos Vitor , Botana Luis
Published: December 2015

Paralytic Shellfish Toxin blooms are common worldwide, which makes their monitoring crucial in the prevention of poisoning incidents. These toxins can be monitored by a variety of techniques, including mouse bioassay, receptor binding assay, and liquid chromatography with either mass spectrometric or pre- or post-column fluorescence detection. The post-column oxidation liquid chromatography with fluorescence detection method, used routinely in our laboratory, has been shown to be a reliable method for monitoring paralytic shellfish toxins in mussel, scallop, oyster and clam species. However, due to its high sensitivity to naturally fluorescent matrix interferences, when working with unconventional matrices, there may be problems in identifying toxins because of naturally fluorescent interferences that co-elute with the toxin peaks. This can lead to erroneous identification. In this study, in order to overcome this challenge in echinoderm and gastropod matrices, we optimized the conversion of Gonyautoxins 1 and 4 to Neosaxitoxin with 2-mercaptoethanol. We present a new and less time-consuming method with a good recovery (82.2%, RSD 1.1%, n = 3), requiring only a single reaction step.
Alkaloids from Veratrum taliense Exert Cardiovascular Toxic Effects via Cardiac Sodium Channel Subtype 1.5
Authors: Wang Gan , Rong Ming-Qiang , Li Qiong , Liu Ya-Ping , Long Cheng-Bo , Meng Ping , Yao Hui-Ming , Lai Ren , Luo Xiao-Dong
Published: December 2015

Several species of the genus Veratrum that produce steroid alkaloids are commonly used to treat pain and hypertension in China and Europe. However, Veratrum alkaloids (VAs) induce serious cardiovascular toxicity. In China, Veratrum treatment often leads to many side effects and even causes the death of patients, but the pathophysiological mechanisms under these adverse effects are not clear. Here, two solanidine-type VAs (isorubijervine and rubijervine) isolated from Veratrum taliense exhibited strong cardiovascular toxicity. A pathophysiological study indicated that these VAs blocked sodium channels NaV1.3–1.5 and exhibited the strongest ability to inhibit NaV1.5, which is specifically expressed in cardiac tissue and plays an essential role in cardiac physiological function. This result reveals that VAs exert their cardiovascular toxicity via the NaV1.5 channel. The effects of VAs on NaV1.3 and NaV1.4 may be related to their analgesic effect and skeletal muscle toxicity, respectively.
New metathesis catalyst bearing chromanyl moieties at the N-heterocyclic carbene ligand
Authors: Hryniewicka Agnieszka , Suchodolski Szymon , Wojtkielewicz Agnieszka , Morzycki Jacek W , Witkowski Stanisław
Published: December 2015

The synthesis of a new type of Hoveyda–Grubbs 2nd generation catalyst bearing a modified N-heterocyclic carbene ligands is reported. The new catalyst contains an NHC ligand symmetrically substituted with chromanyl moieties. The complex was tested in model CM and RCM reactions. It showed very high activity in CM reactions with electron-deficient α,β-unsaturated compounds even at 0 °C. It was also examined in more demanding systems such as conjugated dienes and polyenes. The catalyst is stable, storable and easy to purify.
Stress in Punjabi
Authors: Dhillon Rajdip
Published: December 2015

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Laughing Our Heads Off: When Metaphor Constrains Aspect
Authors: Mateu Jaume , Espinal M. Teresa
Published: December 2015

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The Japanese Contrastive Wa: A Mirror Image of EVEN
Authors: Sawada Osamu
Published: December 2015

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Phonological Structure in Syllabification: Evidence from Dyslexia
Authors: Schneider-Zioga Patricia , Katada Fusa
Published: December 2015

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Language Change in Progress: Evidence from Computer-Mediated Communication
Authors: Tsujimura Natsuko
Published: December 2015

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Creole Phonology: An Alternative to Markedness-Based Accounts
Authors: Ward Whitney
Published: December 2015

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Field Notes on the Pronominal System of Zhuang
Authors: Bodomo Adams
Published: December 2015

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Phonemic Versus Phonetic Correlates of Vowel Length in Chuxnabán Mixe
Authors: Jany Carmen
Published: December 2015

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Directional Markers in Q’anjob’al: Their Syntax and Meaning
Authors: Mateo-Toledo B'Alam
Published: December 2015

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Phonosemantic Evidence for the Mimetic Stratum in the Japanese Lexicon
Authors: Akita Kimi
Published: December 2015

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Palatalization as Overlap of Articulatory Gestures: Crosslinguistic Evidence
Authors: Bateman Nicoleta
Published: December 2015

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On Shallow and Deep Minimality
Authors: Blumenfeld Lev
Published: December 2015

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Backwards Ellipsis is Right Node Raising
Authors: Ha Seungwan
Published: December 2015

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Reflexives and the Shift between First and Second Person: The Case of Japanese
Authors: Ishiyama Osamu
Published: December 2015

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Relations between the Conative and Out-at Constructions: An Extended Semantic Map Approach
Authors: Kim Yong- Taek
Published: December 2015

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Supplemental Relative Clauses and Syntactic Generality
Authors: Lee-Goldman Russell
Published: December 2015

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Focus on Embedded Adverbials
Authors: Ludwig Rainer , Salfner Fabienne , Schenner Mathias
Published: December 2015

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Acoustic Correlates of Prosodic Prominence for Naïve Listeners of American English
Authors: Mo Yoonsook
Published: December 2015

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The Relative Importance of Rhythm and Intonation for the Perception of New Zealand English Dialects
Authors: Szakay Anita
Published: December 2015

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Two Patterns of Reduplication in Washo
Authors: Yu Alan C. L.
Published: December 2015

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Encoding Information Structure via Object Agreement in Spanish Interactions
Authors: Belloro Valeria A.
Published: December 2015

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What’s New (and What’s Given) in the Theory of Focus?
Authors: Buring Daniel
Published: December 2015

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The Roles of Acquisition and Usage in Morphological Change
Authors: Beckner Clay , Wedel Andrew
Published: December 2015

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Promiscuous Modification and Cross-Categorial Scale Structure
Authors: Bochnak M. Ryan
Published: December 2015

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Format Tying and the Acquisition of Syntax in Toddlers’ Peer Interactions
Authors: Koymen S. Bahar , Kyratzis Amy
Published: December 2015

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A Tautology is a Tautology: Specificity and Categorization in Nominal Tautological Constructions
Authors: Kwon Iksoo
Published: December 2015

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Contextual Constraints on Geminates: The Case of Polish
Authors: Pajak Bozena
Published: December 2015

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Decomposing the Non-Manual Tier: Cross-Modality Generalisations
Authors: Goksel Asli , Kelepir Meltem , Untak-Tarhan Asli
Published: December 2015

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nfluences of Linguistic and Non-Linguistic Factors in the Processing of American Sign Language: Evidence from Handshape Monitoring
Authors: Grosvald Michael , Lachaud Christian , Corina David
Published: December 2015

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INFRARED OBSERVATIONAL MANIFESTATIONS OF YOUNG DUSTY SUPER STAR CLUSTERS
Authors: Martínez-González Sergio , Tenorio-Tagle Guillermo , Silich Sergiy
Published: December 2015

The growing evidence pointing at core-collapse supernovae as large dust producers makes young massive stellar clusters ideal laboratories to study the evolution of dust immersed in a hot plasma. Here we address the stochastic injection of dust by supernovae, and follow its evolution due to thermal sputtering within the hot and dense plasma generated by young stellar clusters. Under these considerations, dust grains are heated by means of random collisions with gas particles which result in the appearance of  infrared spectral signatures. We present time-dependent infrared spectral energy distributions that are to be expected from young stellar clusters. Our results are based on hydrodynamic calculations that account for the stochastic injection of dust by supernovae. These also consider gas and dust radiative cooling, stochastic dust temperature fluctuations, the exit of dust grains out of the cluster volume due to the cluster wind, and a time-dependent grain size distribution.
THE RAPID FORMATION OF A FILAMENT CAUSED BY MAGNETIC RECONNECTION BETWEEN TWO SETS OF DARK THREADLIKE STRUCTURES
Authors: Yang Bo , Jiang Yunchun , Yang Jiayan , Yu Shunping , Xu Zhe
Published: December 2015

Taking advantage of the high spatiotemporal resolution observations from the Atmospheric Imaging Assembly (AIA) and the Helioseismic and Magnetic Imager on board the Solar Dynamics Observatory, we present rare observations of the rapid formation of a filament caused by magnetic reconnection between two sets of dark threadlike structures. The two sets of dark threadlike structures belong to distinct flux systems with their adjacent ends anchored in an opposite-polarity magnetic field region, where the calculated photospheric velocity field shows that converging flows dominate there. Due to the converging flows, opposite-polarity magnetic flux converged and then canceled, leading to the formation of extreme ultraviolet (EUV) brightening that spread in opposite directions along the spine of the dark threadlike structures. Meanwhile, very weak remote brightening in the other terminals of the dark threadlike structures, as well as EUV loops, which rooted in the opposite-polarity magnetic field region, appeared. In addition, all of the AIA Fe line observations reveal that a flux rope was formed and underwent a rolling motion during the fadeaway of the EUV brightening. Soon after, as the EUV brightening disappeared, a filament that is very likely composed of two sets of intertwined dark threadlike structures was formed. Via differential emission measure (EM) analysis, it is found that both the EM and temperature of the plasma around the flux-canceling site increased during the brightening, implying that there, magnetic reconnection may occur to heat the plasma. These observations provide evidence that the filament is formed by magnetic reconnection associated with flux convergence and cancellation, and the magnetic structure of the filament is most likely a flux rope.
Oral Candida colonization in HIV-infected patients in Londrina-PR, Brazil: antifungal susceptibility and virulence factors
Authors: De Paula Suelen Balero , Morey Alexandre Tadachi , Santos Jussevania Pereira , Dos Santos Pollyanna M. C. , Gameiro Danielle G. , Kerbauy Gilselena , Sena Ester M. , Ueda Luiz T. , Carneiro Marcelo , Pinge-Filho Phileno , Yamauchi Lucy Megumi , Yamada-Ogatta Sueli Fumie
Published: December 2015

Introduction: Host colonization by Candida species is an important predisposing factor to candidiasis, which seems to be more frequent in human immunodeficiency virus (HIV)-infected patients. Knowledge about the distribution, antifungal susceptibility, and virulence of oral Candida isolates is important for effective management of candidiasis. Methodology: Oral rinses were collected from 242 HIV-infected patients without clinical evidence of candidiasis seen at the AIDS referral center in Londrina, Brazil. Species were identified by standard phenotypic and molecular methods, and characterized in vitro according to antifungal susceptibility, cell surface hydrophobicity, biofilm formation, and enzyme activities. Results: Oral Candida colonization was detected in 50.4% of patients and combined use of antiretroviral therapy and protease inhibitor had a protective effect against colonization. Candida albicans (75.2%) was the most prevalent species. A high proportion of Candida spp. (39.9%) showed decreased susceptibility to fluconazole. Five isolates were resistant to nystatin. Protease and phospholipase activities were detected in 100% and 36.8% of isolates, respectively. Most isolates displayed a hydrophobic property that was associated with biofilm formation ability. Conclusions: A significant number of oral Candida species exhibiting decreased susceptibility to fluconazole were isolated from colonized HIV-infected individuals. Furthermore, all isolates expressed potential virulence attributes in vitro. Given the high incidence and severity of fungal infections in HIV-infected individuals, the results of this study reinforce the importance of antifungal susceptibility testing, which contributes to therapeutic strategies and highlights the need for continuous surveillance of Candida colonization in this population.
L’infra de l’humain : du mode mineur de la réalité à l’anthropologie existentiale dans l’œuvre d’Albert Piette
Authors: Denizeau Laurent
Published: December 2015

La notion de « mode mineur », au centre de l’œuvre de l’anthropologue Albert Piette, nous invite à repenser l’homme des sciences humaines et sociales. A la fois outil méthodologique et concept épistémologique fondateur d’une anthropologie existentiale, attentive non plus aux représentations sous-jacentes à l’action mais au mode spécifiquement humain d’être au monde. Comment écrire anthropologiquement l’existence humaine ? Sur un mode mineur. Bien plus qu’un outil méthodologique et un concept épistémologique, le mode mineur nous invite à une véritable pensée de la minimalité.
Spontaneous Regression of Primitive Merkel Cell Carcinoma
Authors: Cirillo Fernando
Published: December 2015

Merkel cell carcinoma (MCC) is a rare, aggressive skin tumor that mainly occurs in the elderly with a generally poor prognosis. Like all skin cancers, its incidence is rising. Despite the poor prognosis, a few reports of spontaneous regression have been published. We describe the case of a 89-year-old male patient who presented two MCC lesions of the scalp. Following biopsy the lesions underwent complete regression with no clinical evidence of residual tumor up to 24 months. The current knowledge of MCC and the other cases of spontaneous regression described in the literature are reviewed.
Giant Scrotal Fibrolipoma
Authors: Mykoniatis Ioannis , Metaxa Linda , Nikolaou Vasilios , Filintatzi Chrysa , Kikidakis Dimitrios , Sountoulides Petros
Published: December 2015

Fibrolipoma, an infrequent histological subtype of lipoma, is considered a benign mesenchymal neoplasm. Fibrolipoma of the scrotum is an even more rare entity. We report a case of a 55-year-old male complaining for a slow-growing, painless mass in his left hemis-crotum. Imaging with ultrasonography and magnetic resonance imaging was inconclusive regarding the nature of the tumor and the tumor was excised, sparing the testis. The surgical specimen was a well-defined, yellowish white, solid, and firm mass, measuring 19.5×7×5 cm. There was no cytological atypia or mitosis and no lipoblasts recognized. On immunohistochemistry, MDM2 and CDK4 were not expressed. The histopathology report was fibrolipoma of the scrotum. To the best of our knowledge, this is only the fourth case of fibrolipoma originating from the scrotal components, spermatic cord or testis that has been reported in the English literature.
Representación de género. Las películas españolas contemporáneas de adolescentes (2009-2014)
Authors: Álvarez Hernández Carmen , González de Garay Domínguez Beatriz , Frutos Esteban Francisco Javier
Published: December 2015

El presente estudio partió de los múltiples informes sobre los elevados índices de Desigualdad de Género en nuestra sociedad y de la gran influencia del relato audiovisual para la configuración de la misma. Nos planteamos si los largometrajes contemporáneos de producción española y de adolescentes reproducían esa imagen de género desigual. Metodología. Se estudió a los protagonistas de las películas más vistas con un elenco de adolescentes de más del 50% entre los años 2009-2014, analizando el número de personajes masculinos y femeninos en ellos y la reproducción de ocho estereotipos de género. Resultados. Los resultados manifestaron la reproducción de una imagen de género desigual, con estereotipos argumentales y de definición de personajes y roles que no hacen sino alimentar la creación y continuación de una imagen colectiva en los espectadores adolescentes sobre cómo son los hombres y las mujeres, contribuyendo a perpetuar la desigualdad de género.
Bogataj in Del Gobbo (ur.) (2015). Lifelong learning devices for sustainable local development. Gorizia, Comitato regionale dell‘Enfap del Friuli Venezia Giulia
Authors: Muršak Janko
Published: December 2015

V okviru programa čezmejnega sodelovanja, ki ga sofinancira Evropski sklad za regionalni razvoj, je izšla monografija o čezmejnem delovanju študijskih krožkov ob slovensko- -italijanski meji z naslovom Lifelong learning devices for sustainable development ter s podnaslovom The study circles experience in the cross border area Italy-Slovenia.
Razvoj neformalnega izobraževanja odraslih skozi zgodovino Zasavske ljudske univerze
Authors: Govekar-Okoliš Monika , Fakin Manja
Published: December 2015

Prispevek obravnava razvoj neformalnega izobraževanja na Zasavski ljudski univerzi primerjalno skozi dve zgodovinski obdobji. Prvo obdobje je od 1984 do 1991, ko je ljudska univerza delovala v državi Jugoslaviji, drugo obdobje je od 2004 do 2011, v času države Slovenije in sodelovanja z Evropsko unijo. Kakšen je bil razvoj neformalnega izobraževanja, smo raziskovali na podlagi analize ohranjenih izobraževalnih programov za odrasle na Zasavski ljudski univerzi. Zanimalo nas je, kakšna je bila razlika v spolni in starostni strukturi udeležencev v splošnem neformalnem izobraževanju skozi zgodovino. Razkrivali smo vire financiranja in ugotovili, kakšen je bil trend vključevanja odraslih v to izobraževanje. Skozi primerjalno zgodovinsko analizo smo spoznali, da je bilo splošno neformalno izobraževanje odraslih na Zasavski ljudski univerzi v prvem obdobju veliko manj razširjeno kot v drugem obdobju, da so obstajale tako razlike v spolni in starostni strukturi udeležencev kot tudi v finančnih virih. Ugotovili smo temeljne razlike tudi v trendu tovrstnega izobraževanja odraslih.
Zaposljivost – izziv za izobraževanje
Authors: Kelava Polona
Published: December 2015

Lahko bi rekli, da je rdeča nit te številke revije zaposljivost, kar pa ni nujno vidno na prvi pogled. Teme, s katerimi se srečamo v člankih, se, ponekod tudi posredno, povezujejo z eno ali več kompetencami posameznikov v različnih vlogah, ali pa njihovih učencev, pomembnih za zaposljivost, s ponudbo programov, ki lahko povečajo zaposljivost, s problematiko samozaposlenih (na specifičnem področju) in podobno.
Assessment of intercultural competence of vocational teachers in Croatia
Authors: Rajić Višnja , Rajić Tomislav
Published: December 2015

Due to the changes in society and the new era of “super-diversity” (Vertovec, 2007) in European countries, intercultural competence is gaining importance both in everyday life situations and teacher training. In the academic year of 2014/2105, a research was conducted on a sample of 136 prospective secondary school teachers undergoing their pedagogical-didactical-methodological training in different universities in the Republic of Croatia. The tool that was employed in the self-assessment of intercultural competence was called Recognising intercultural competence: What shows that I am interculturally competent? The results showed that the examinees perceive their intercultural competence quite high; attitudes (M = 4,09); skills (M = 4,12); knowledge (M = 4,02). There is no significant difference between the perceived dimensions (p = ,282). Further research is recommended to better understand the insights about the examinees’ understanding of intercultural competence.
Validation of non-formal and informal learning from a European perspective – linking validation arrangements with national qualifications frameworks
Authors: Mikulec Borut
Published: December 2015

The paper analyses European policy on the validation of non-formal and informal learning, which is presented as a “salvation narrative” that can improve the functioning of the labour market, provide a way out from unemployment and strengthen the competitiveness of the economy. Taking as our starting point recent findings in adult education theory on the validation of non-formal and informal learning, we aim to prove the thesis that what European validation policy promotes is above all economic purpose and that it establishes a “Credential/Credit-exchange” model of validation of non-formal and informal learning. We proceed to ecxamine the effect of European VNIL policy in selected European countries where validation arrangements are linked to the qualifications framework. We find that the “Credential/ Credit-exchange” validation model was first established in a few individual European countries and then transferred, as a “successful” model, to the level of common European VNIL policy.
Modularno usposabljanje kariernih svetovalcev – MUKS
Authors: Goršak Maruša
Published: December 2015

V Sloveniji je minilo deset let od prvih poskusov, da bi tudi v našem prostoru oblikovali enoten in celovit formalni izobraževalni program za svetovalce na področju vseživljenjske karierne orientacije. Posamezne organizacije, ki izključno ali kot eno izmed svojih dejavnosti izvajajo storitve vseživljenjske karierne orientacije, so sicer vzpostavile interne sisteme usposabljanja zaposlenih, a do izvedbe prvega skupnega pilotnega usposabljanje kariernih svetovalcev v Sloveniji smo morali počakati še nekaj let. Korak naprej je bil storjen v sklopu projekta »Nacionalna koordinacijska točka za vseživljenjsko karierno orientacijo «, ki je omogočil izvajanje prvega skupnega izobraževanja svetovalcev na področju VKO – Modularnega usposabljanja kariernih svetovalcev, ki je predstavljen v članku.
Linguistic Features of Persuasive Communication: The Case of DRTV Short Form Spots
Authors: Komar Smiljana
Published: December 2015

Direct response television commercials (DRTV) exhibit a very specific style of speech and delivery whose main function is to boost the product’s value and sales. This paper presents the findings of the structural and the linguistic analyses of three English DRTV short form spots as seen on Highstreet TV. The emphasis is on the verbal strategies used by advertisers to get the consumers’ attention, develop their interest and desire to own the product and to convince them to purchase it. These strategies include different lexical, syntactic and prosodic features. The structural analysis focuses mainly on non-verbal strategies of broadcasting advertisements whose purpose is to inspire interest and credibility in potential consumers.
English Words and Phrases in Croatian: A Small-Scale Study of Language Awareness and Attitudes
Authors: Perić Marija , Škifić Sanja
Published: December 2015

The focus of this paper is on language attitudes towards English words and phrases in the Croatian language. In order to prevent loanwords, linguistic purism has arisen as a theory about what languages should be like. The tradition of linguistic purism in Croatia has been shaped by various socio-historical factors. English may be viewed as a language of opportunity, or as a threat to the survival of other, usually minority and endangered, languages. In order to provide an insight into the use of English words and phrases in the Croatian context, a questionnaire about language attitudes and awareness was conducted on 534 participants. The aim of the questionnaire was to determine participants’ language attitudes and familiarity with English words and phrases. The results show that although people in Croatia generally like English, many of them are not familiar with English words, especially older participants and those with little or no knowledge of the English language. Moreover, the results indicate that the younger generation is more inclined towards English than the older generation; however, they are not as familiar with Croatian equivalents as they claim.
An investigation of relationships between cognitive factors associated with worry
Authors: Voon David , Phillips Lisa J
Published: December 2015

Worry is a common human experience which, if excessive, can be associated with functional impairment. The experience of worry has been associated with a number of higher-order cognitive processes; however it is unclear how these processes relate to one another. This study was conducted with a non-clinical sample of 123 participants to explore relationships between several psychological factors in reflection of the dimensional nature of worry. Intolerance of uncertainty, the looming cognitive style, beliefs about worry and meta-worry each independently contributed to worry, accounting for 59% of the variance in worry scores when considered together. Intolerance of uncertainty and looming cognitive style were not independent predictors of worry when beliefs about worry and meta-worry were taken into consideration. Indeed, only positive beliefs about worry and meta-worry emerged as independent predictors in the full model that was explored. Of note, meta-worry mediated the relationship between negative beliefs about worry and worry. These results suggest that an integrated model of the mechanisms that underlie worry needs to take a number of cognitive constructs into account and that cognitive therapies targeting worry should have a particular emphasis on perceptions that worrisome thoughts are dangerous, harmful and growing rapidly uncontrollable.
Suppression, Acceptance, and Monitoring of Personally-Relevant Unwanted Thoughts in Women Diagnosed with Borderline Personality Disorder
Authors: Pistorello Jacqueline , Hayes Steven C. , Costello Ellen , Simpson Elizabeth , Begin Ann , Rosen Karen , Pearlstein Teri
Published: December 2015

Recent evidence suggests that patients with Borderline Personality Disorder (BPD) experience less immediate distress while suppressing unwanted thoughts, despite the negative long-term outcomes of that strategy longitudinally and in treatment settings. The present study investigated the impact of 8-minute audiotaped suppression/thought control, acceptance, and monitoring instructions on moderately distressing and personally relevant thoughts in women (N = 51; 17 per condition) diagnosed with BPD. Strategies were applied in a 5-minute think-aloud period, followed by a similar period without the strategy, and then a wind-down task. Those in the suppression condition reported less subjective distress throughout but showed evidence of attempts at distraction through increased talking in the second period. Participants in the suppression group with higher experiential avoidance showed more thought intrusions during the main task period and lower positive affect during the wind-down task than those in other conditions. Suppression appears to produce some negative outcomes in this population despite resulting in less self-reported distress.
Mother-Child Interpersonal Dynamics: The Influence of Maternal and Child ADHD Symptoms
Authors: Nilsen Elizabeth S. , Lizdek Ivana , Ethier Nicole
Published: December 2015

The relations between maternal and child ADHD symptoms and interpersonal behaviour were examined. Mother-child dyads (N = 59), with children 8- to 12-years-old, exhibiting a range of ADHD symptoms, participated in a problem-solving task. Participants' interpersonal behaviours (along continuums of affiliation: friendliness-hostility and control: dominance-submissiveness) were coded on a continuous moment-to-moment basis, as the interaction unfolded, using a joystick technique. Elevated ADHD symptoms, in both mothers and children, were associated with less overall affiliative interpersonal behaviour. Further, while dyads generally showed complementary behaviour, dyads in which the child had elevated ADHD symptoms demonstrated less complementarity on the affiliation dimension. Finally, the higher the child's ADHD symptoms, the less affiliative and less dominant the mother became over the course of the interaction. Findings highlight ways in which individual differences in ADHD behaviour impact interpersonal functioning and have implications for interventions aimed at enhancing parent-child relationships.
CONOCIMIENTO, PERCEPCIÓN Y ACTITUD SOBRE LA ENFERMEDAD DE CHAGAS EN UN CENTRO DE REFERENCIA URBANO
Authors: López Stella Maris , Salomón Oscar Daniel
Published: December 2015

La tendencia para las próximas décadas de la enfermedad de Chagas (ECh) es la dispersión hacia los centros urbanos. El objetivo de este trabajo fue explorar, a partir de una encuesta semiestrucuturada, conocimientos, actitudes y percepción de la ECh en 153 adultos que asistieron al Instituto Nacional de Parasitología entre marzo a octubre de 2004 para confirmación de su diagnóstico. Se identificó en el 66% de la población un conocimiento básico relacionado al vector y las afecciones cardíacas. El 62% consideró a la ECh grave y una vez conocido el diagnóstico el 80% buscó asesoramiento. El 84% no se consideró incapacitado, pero al tratar de ingresar a trabajos formales encontraron dificultades para su inserción. Cuando se les propuso sugerir propuestas de mejoramiento el 56% destacó la importancia sobre nuevos tratamientos, información y la visibilidad de la ECh. Este trabajo revela un conocimiento limitado, una percepción de gravedad de la ECh y por lo tanto una buena disposición para desarrollar acciones de apoyo, educativas, y de prevención en esta población.
The Habitus of Actor on Corporate Social Responsibility Program: A Study on PT Antam in Nanggung Sub-District of Bogor Regency
Authors: Pranawa Sigit , Mardikanto Totok , Kartono Drajat Tri , Soemanto RB
Published: December 2015

The objective of research was to find out the habitus of actor on  PT Antam’s corporate social responsibility (CSR) program implementation in developing the clean water infrastructure, particularly involving the society leader and the members of society, as well as the staff of PT Antam. In this case, the leader was Lurah Desa Cisarua (the Head of Cisarua Village) attempting to make both company and society benefiting from the presence of company amid the society. The research method used was case study. Techniques of collecting data used were observation, interview, and focus group discussion (FGD). Technique of analyzing data used was an interactive model. Bourdieu’s structuring theory was used to appreciate the leader’s action. This theory states that (habitus × capital) + domain = action. The result of research suggested that the community of Nanggung Sub District was the domain in which the actor exists, pertaining to values, norms, and problems encountered by the society. Habitus of society leader constituted knowledge and conception on its role and function within the society, learnt from its primary and secondary environments. The result also showed that a society leading actor should be able to serve the society by devoting idea, thought, and effort to its society. The members of society should be able to participate actively in the society’s activity. Meanwhile, the actor of company should be productive and maintain the company’s reputation. Capital consists of economic, social, cultural, and political capitals the individual actors have.
In-silico designing of hnRNP B1 inhibitors against lung cancer: a computational approach
Authors: Verma Neelam , Kaur Gurpreet
Published: December 2015

RNA-binding proteins regulate the maturtarion of mRNA including pre-mRNA splicing, mRNA transport from the nucleus to cytoplasm, the translocation and longevity of transcripts within the cytoplasm as well as translation of the message. One key RNA-binding protein identified in several aspects of this process is heterogeneous ribonuclear ribonucleoprotein B1 (hnRNP B1) and it plays a role in several cellular functions.  HnRNP B1 is overexpressed in several cancers including lung and squamous cell carcinoma of various organs, in addition, its mRNA can be detected in the serum of patients with early stage lung cancer and can therefore be used as a biomarker for cancer detection.  Furthermore, it can be used as a target for treatment. In the present study hnRNP B1 was used as a target receptor for in silico ligand binding studies using a library of 55 small compounds selected from the current knowledge of lung cancer therapeutic drugs available in the market as well as known inhibitors of hnRNP B1. TSAR studies were carried out for selected compounds from BioMed CAChe to determine docking score and then compared with 7 lactate dehydrogenase inhibitor involved in lung cancer whose IC50 value were known. Results from both software analyses indicated that EGCG was a potent candidate ligand of hnRNP B1 and was selected as a parent compound for pharmacophore modifications to improve the binding affinity and activity against hnRNP B1. A library of 158 compounds was generated after modification of EGCG and molecular modeling and docking identified several analogues with increased binding scores. In addition, pharmacophore studies indicated the significant importance of ring D in EGCG and the formation of H-bonds between the modified ligands and amino acid GLU108 of hnRNPB1. Hence the outcomes of study identify a strategy for the identification of new lead molecules bearing drug-like properties. Future studies are required to validate this approach and measure the efficacy of analogues of compounds identified using in silico approaches.
The Relationship between Supply Chain CPAs, CSR and Discretionary Accruals
Authors: Liu Li-Lun , Huang Yu-Ting
Published: December 2015

This research explores the corporate social responsibility (CSR) performance of listed companies in Taiwan by looking at how companies meet their CSR obligations and by exploring how employing supply chain certified public accountants (CSRSCPAs) affects the quality of their earnings. However, despite the benefits stemming from enhanced information corroboration and expertise spillover, CSRSCPAs face the challenge of potential information collusion. It finds that the CSRSCPA has a negative effect on discretionary accruals. Hence, this study looks at supply chain CPAs in the context of the company’s CSR performance to find out the impact of the company’s financial statements. In addition, the results of this study indicate that both a positive earnings quality and a positive public response ensue when the Big 4 audit firms audit CSR companies. Our results show that market participants highly value Big 4 supply chain CPAs with industry experience and that these impressions extend to their evaluation of clients. The inclusion of different supply chain streams reveal that upstream CSRSCPA are more likely than middlestream and downstream CSRSCPA to receive favorable reactions from market participants. This is an indication that market participants are impressed by the specific expertise and knowledge of these professionals.