bluuebunny/crossref_metadata_2025 huggingface dataset:
Correlation between Radiological Outcome and Health Related Quality of Life after Posterior Spinal Fusion for Adolescent Idiopathic Scoliosis
Authors: Chaudhary Rajesh Kumar , Kaucha Deepak , Banskota Bibek , Barakoti Ram Krishna , Banskota Ashok Kumar
Published: April 2021

Background: Posterior spinal surgery for adolescent idiopathic scoliosis is aimed at correcting deformity and stopping deformity progression to improve the health related quality of life. The correlation between radiological outcome and health related quality of life is yet unclear. This study aimed to assess the correlation between radiological outcome and health related quality of life.Methods: A descriptive cross-sectional study of 31 cases of adolescent idiopathic scoliosis who underwent posterior spinal surgery at our center from July 2013 to August 2019, was done. Radiological outcomes were measured by the Cobb’s angle before and after surgery in standing whole spine X-ray and compared by paired t-test. Health related quality of life was measured by Scoliosis Research Society-30 questionnaire. Correlation between radiological outcomes and Scoliosis Research Society-30 and its domains were assessed by Pearson’s correlation coefficient, and Spearman’s rank correlation coefficient.Results: There were 18 females (58.06%) and 13 males (41.93%) with a mean age of 14.81 years (range 12-18 years). Average post-operative follow-up was 37 months (range 6-82 months).The mean amount of deformity correction post-operatively was 460 (range 300-740). The mean of total SRS-30 score was 137.64±7.84. The post-operative Cobb angle correlated significantly with the mean total Scoliosis Research Society-30 score (p=0.046). Self-image/appearance and satisfaction with management correlated significantly with residual deformity and amount of deformity correction. Self-image/appearance and pain correlated significantly with satisfaction with management. Self-image/appearance had a significant positive correlation with mental health (p=0.004). Conclusions: Posterior spinal surgery for adolescent idiopathic scoliosis provided better radiological outcomes, and a positive correlation with health related quality of life. There was significant improvement of self-image/appearance and satisfaction after surgery, which in turn, improved mental health. Keywords: Adolescent idiopathic scoliosis; health related quality of life; posterior spinal surgery; radiological outcome
Deteksi Dini Gangguan Pembatas Arus Listrik Pada PHB-TR Bertegangan Tinggi Broadcast SMS Gateway
Authors: Yusa Mochammad , Santoso Joko Dwi
Published: April 2021

Abstrak - Gangguan pecahnya NH FUSE atau pembatas arus listrik di PHB-TR jika tidak cepat ditangani tentu menimbulkan kerugian, tegangan di bawah standar yang menyebabkan eletronic eqiupment mudah rusak, dan peralatan distribusi aset PLN yang juga akan rusak trafo. Salah satu faktor penting yang bisa terjadi adalah keterlambatan informasi yang diterima oleh petugas PLN dan pelanggan tidak segera repot ke kantor PLN. Gangguan pecahnya sistem peringatan dini NH FUSE menggunakan SMS gateway berbasis sensor tegangan, yang dirancang untuk memberikan informasi sedini mungkin gangguan, bertujuan agar dapat ditangani dengan cepat sehingga kerusakan pelanggan peralatan elektronik dan transformator aset PLN dapat diminimalisir.Kata Kunci: Disruption of NH FUSE, Microcontroller, SMS Gateway.
Implementasi dan Analisis Arduino Dalam Rancang Bangun Alat Penyiram Tanaman Otomatis Menggunakan Aplikasi Android
Authors: Mardiana Yessi , Riska Riska
Published: April 2021

Selama ini, penyiraman tanaman dilakukan secara manual. Akan tetapi, terkadang kita tidak punya cukup waktu untuk menyiram tanaman. Oleh karena itu, dibutuhkan suatu alat yang dapat membantu meringankan kegiatan menyiram tanaman. Alat tersebut berupa sistem yang dapat bekerja secara otomatis. Dengan menggunakan alat ini, maka diharapkan penyiraman tanaman dapat dilakukan pada waktu dan saat yang tepat. Dalam penelitian ini, alat penyiram tanaman otomatis dengan android berbasis Arduino Uno, menggunakan Arduino Uno sebagai sistem pengendalian, modem digunakan sebagai penerimaan perintah yang dikirim melalui smartphone android. Penelitian ini bertujuan untuk memberikan kemudahan dalam penyiraman tanaman secara otomatis berdasarkan waktu yang ditentukan dan kondisi cuaca yang terjadi dengan memnggunakan rain sensor sehingga proses penyiraman tanaman dapat dijadwalkan sesuai dengan kebutuhan dari tanaman tersebut.Kata Kunci: Alat Penyiram Tanaman, Arduino, Android
Pembinaan Akademik untuk Meningkatkan Kemampuan Guru SMA Sumatera 40 Bandung Membuat Perencanaan Pembelajaran
Authors: Mandirisari Ida Suciati
Published: April 2021

Guru harus memfasilitasi dan mengambangkan kemampuan memecahkan masalah sejak dini pada diri siswa SMA, dengan memasukan kemampuan tersebut pada perencanaan pembelajaran yang dibuatnya. Penelitian ini bertujuan untuk meningkatkan keterampilan berpikir tingkat tinggi pada siswa. Metode penelitian yang digunakan adalah penelitian tindakan sekolah, yaitu melaksanakan pembinaan bagi sekelompok guru di suatu sekolah, melalui beberapa siklus, mengunakan sistem spiral refleksi model Kemmis dan Mc Taggart yang dimodifikasi. Strategi/metode kerja/ teknik pembinaan yang digunakan dari siklus I sampai siklus II menggunakan model supervisi klinis melalui observasi-refleksi-rekomendasi, studi dokumentasi angket, FGD, dan presentasi produk RPP. Hasil penelitian menunjukkan bahwa setelah dilaksanakan supervisi model supervisi klinis, kemampuan guru dalam membuat perencanan pembelajaran berbasis pemecahan masalah, sudah menunjukkan adanya peningkatan, dari siklus I ke Siklus II. Siklus II mengakhiri pembinaan, dengan indikator skor guru minimal 80.00 sudah diatas 85%, yaitu sebesar 100%.
PENGARUH DEBT TO EQUITY RATIO (DER) DAN EARNING PER SHARE (EPS) TERHADAP HARGA SAHAM (STUDI KASUS PADA PERUSAHAAN SUB SEKTOR PERTAMBANGAN BATUBARA YANG TERDAFTAR DI BURSA EFEK INDONESIA PERIODE TAHUN 2014 – 2019)
Authors: Budiyani Putri Asri , Dailibas Dailibas
Published: April 2021

The development of the coal mining subsector companies have decreased, especially in stock prices. The companies performance is the main point for investors to invest in the middle of a less good level influenced by various factors, including due to debt and profit. Financial statements are a proof of the companies performance. Searching for these factors is done by analyzing financial ratios related to debt and profits. The purpose of this research is analyze whether DER and EPS have a partial and simultaneous effect on stock prices. The population are all coal mining subsector companies listed on the Indonesia Stock Exchange (BEI) in the period 2014-2019 with a sample of 10 companies. This research is quantitative with purposive sampling technique. The data used are financial statements published by the Indonesia Stock Exchange (BEI) and then processed using SPSS for Windows 25. The results of the research get that partially DER has no effect on stock prices while EPS has an effect on stock prices.  Simultaneously the DER and EPS have effects together on stock prices.  Based on the results of DER and EPS with regression models, the variables have a strong influence on stock prices with determination were 37%. The biggest influence was contributed is EPS by 31% and then DER by 6%.
PELAKSANAAN PUTUSAN PENGADILAN AGAMA MENGENAI TANGJUNG JAWAB AYAH TERHADAP BIAYA PEMELIHARAAN SETELAH PERCERAIAN
Authors: Amrudi Amrudi
Published: April 2021

Islam adalah sebuah  agama yang berbentuk  sebuah peraturan  hidup yang menjadi sumber  rahmat dan  kebahagiaan  bagi seluruh kaum  muslim. Manusia  diturunkan bersama  dengan peratuaran hidupnya  agar tidak terjadi benturan  dan ketidakseimbangan. Bantuan dan ketidakseimbangan  ada ketika manusia  mulai mencampakkan   islam  sebagai  peraturan  dalam hidupnya. Perkawinan merupakan  salah satu perintah  agama kepada  yang mampu untuk segera melaksanakannya. Karena perkawinan dapat mengurangi  kemaksiatan,  baik dalam bentuk  penglihatan maupun dalam bentuk  perzinaan. Orang yang berkeinginan untuk melakukan pernikahan, tetapi  belum mempunyai  persiapan bekal (fisik dan nonfisik) dianjurkan Oleh Nabi Muhammad SAW,  untuk berpuasa. Orang berpuasa akan memiliki kekuatan atau penghalang dari berbuat  tercela  yang sangat keji,  yaitu perzinaan. Keluarga  harus terbentuk dari pondasi yang kokoh. Pondasi tersebut adalah  akidah islam, ikatan atas dasar  keutamaan agama (dien).  Dengan niat, cara, peroses pernikahan  yang sesuai  dengan syariat islam, maka restu akan menjadi doa dari semua yang menyaksikan  ikatan tersebut. Maka sakinah,  mawaddah, warohmah muda  dicapai.

Kesimpulan Penelitian ini Bahwa anak yang belum berumur 12 tahun (mumayyiz) dibawah pengasuhan ibunya, bahwa biaya pengasuhan anak di tetapkan Rp.1.000.000.00 perbulan ditentukan karenakan mantan suami memiliki hutang pada pihak lain  walaupun pengahsilan kurang dari Rp 4.000.000.00. Bahwa untuk mendapatkan sentuhan kasih sayang  dari kedua orang tua yang bercerai diberi hak keduanya memberikan perhatian  kasih sayang masing-masing sesuai punsinya, ibu merawat dan ayah memberi mafkah hidup. Dalam kata lain si ibu tidak berhak memonopolo pengasuhan anak tanpa memberikan kesempatan pada ayahnya.
MODEL PEMBELAJARAN INTERAKTIF KELOMPOK PADA MATA PELAJARAN SENI TARI
Authors: Shalihat Hilma Mitalia
Published: April 2021

Model pembelajaran interaktif adalah kegiatan guru secara terprogram dalam desain instruksional, untuk membuat siswa belajar aktif, yang menekankan pada penyediaan sumber belajar. Penelitian ini bertujuan untuk mendeskripsikan dan mengetahui: (1) Pelaksanaan pembelajaran seni tari di SMP Bina Sejahtera, (2) Faktor penghambat dan pendukung yang dihadapi dalam model pembelajaran Interaktif Kelompok pada Mata Pelajaran Seni Tari di Bina Sejahtera. Penelitian ini menggunakan penelitian kualitatif, dengan fokus penelitian pelaksanaan model pembelajaran Interaktif Kelompok pada mata pelajaran seni tari di Bina Sejahtera. Teknik pengumpulan data menggunakan observasi, wawancara dan dokumentasi. Teknik analisis data dengan cara mereduksi, penyajian data dan menyimpulkan semua informasi secara benar. Hasil penelitian menunjukkan bahwa pembelajaran tari dimulai dengan pendahuluan, kegiatan inti dan penutup. Hasil pembelajaran dapat dilihat dari segi kognitif, afektif, dan psikomotorik. Pembelajaran Interaktif kelompok mempunyai faktor penghambat dan pendukung. Saran dalam penelitian ini yaitu motivasi siswa dalam pembelajaran Seni Tari lebih ditingkatkan supaya siswa putra tidak ada lagi yang beranggapakan menari hanya untuk siswa putri, dan pembelajarn lainnya di Bina Sejahtera sebaiknya menggunakan model pembelajaran interaktif kelompok.
ANALISIS LOYALITAS PELANGGAN DITINJAU DARI FAKTOR KEPERCAYAAN DAN KEPUASAN PELANGGAN PADA BENGKEL SEPEDA MOTOR AHASS 2192
Authors: Chairy Putra
Published: April 2021

Penelitian ini bertujuan untuk mengetahui “Pengaruh Kepercayaan dan Kepuasan Pelanggan Terhadap Loyalitas Pelanggan pada Bengkel Sepeda Motor AHASS 2192 Medan.Jenis penelitian ini adalah asosiatif. Populasi dalam penelitian ini adalah seluruh pelanggan pada Bengkel Sepeda Motor Ahass 2192 Medan sebanyak 150 pelanggan dengan menggunakan teknik rumus slovin, maka jumlah sampel dalam penelitian ini sebanyak 109 responden diambil dari sebagian populasi. Berdasarkan hasil uji t dapat dilihat bahwa thitung pada variabel kepercayaan dan kepuasan sebesar berpengaruh terhadap variabel loyalitas secara parsial.Berdasarkan hasil uji F maka menunjukan kepercayaan dan kepuasan secara serempak berpengaruh secara positif dan signifikan terhadap variabel loyalitas. Nilai Adjusted R Square yang diperoleh sebesar 0,451 atau 45,1%. loyalitas dapat dijelaskan oleh kepercayaan dan kepuasan. Sisanya sebesar 54,9% dipengaruhi oleh faktor-faktor lain yang tidak dijelaskan dalam penelitian ini
Joining Militia; Understanding the Drivers of Militia Participation in Counterinsurgency Operation in Yobe State, Nigeria
Authors: Gana Modu Lawan
Published: April 2021

The Nigeria government has been fighting a protracted insurgency by Boko Haram since 2009. Despite the concerted multifaceted counterinsurgency approach, the insurgent sustained its violence with impunity. However, the participation of militia to support the government significantly suppressed the insurgent hostilities, reduced both attack frequencies and fatalities. Even though the militias succeed in the operation, but what motivates them to engage in the militia is not address. This article, therefore, drawing data from interviews and field observations, this study investigated the drivers of the militias in Yobe State. The case study is at Geidam involving 15 participants from three groups that include the militia participants, government officials, and community leaders. The find revealed poverty and unemployment are the key drivers of militias' participation in the operation. However, the study recommends that Nigeria and Yobe State governments should regulate the militia activities to avoid excessiveness. Nigeria's government should re-strategize its counterinsurgency campaign toward the people-centered operation. Others are the recruitment of more state counterinsurgent forces by the government.
Faik Reşad’ın Mürüvvet Gazetesindeki İmla ile İlgili Makaleleri
Authors: TUĞLUK Mehmet Emin
Published: April 2021

Türk dilinin kurallarının belirlenmesi ve imla ile ilgili konularda düzenleme yapılması ile ilgili tartışmalar 19. yüzyılın ilk çeyreğinden itibaren belirgin bir şekilde artmıştır. Gazete ve dergiler etrafında gerçekleşen bu tartışmalar genellikle dilin sadeleşmesi, Türkçenin gramerinin yazılması ve imlada birlik konularında yoğunlaşmıştır. Dönemin önde gelen şair ve yazarlarının pek çoğu doğrudan veya dolaylı olarak bu tartışmalara katılmışlardır. Faik Reşad da dil ve imla konusundaki bu tartışmalara doğrudan katılmış yazarlardandır. Faik Reşad’ın Mürüvvet gazetesinde 1888 yılında yayımlanan “İmlâ” başlıklı sekiz makaleden oluşan yazı dizisi belirttiğimiz konuları ele almaktadır. Faik Reşad bu yazı dizisinde “Her millet milliyetini lisân ile muhafaza eder. Bundan dolayı bizim öncelikle dilimizi ve imlamızı kurallara bağlamakla işe başlayıp dilimizi ıslah etmemiz gerekir” düşüncesini ileri sürerek bu konuda birtakım görüş ve önerilerde bulunmaktadır.
Bu çalışmada Faik Reşad’ın Mürüvvet gazetesinde yayımlanan imla ile ilgili makalelerinin çevirisi yapılmış ve bu makalelerden hareketle Faik Reşad’ın dil ve imla ile ilgili görüşlerine yer verilmiştir.
Programa Saúde na Escola: O que revelam as produções científicas na área de educação?
Authors: Farias André Leite de , Ferreira Valdivina Alves
Published: April 2021

Este artigo tem como objetivo analisar a produção científica sobre o Programa Saúde na Escola no período de 2014 a 2019, na área de educação. Para tanto, adotou-se pressupostos da pesquisa qualitativa. Quanto à abordagem, foram utilizados procedimentos metodológicos de pesquisa documental e bibliográfica, sobretudo por meio do Portal Capes e da plataforma Scielo. Os resultados mostraram duas teses e nove dissertações, classificadas por autor, instituição, ano de publicação, título da produção, bem como dois artigos científicos, classificados por autores, revista, ano de publicação, título de produção científica. A triangulação de dados levou em consideração os problemas de pesquisas estabelecidos pelos autores das produções científicas, o Decreto 6.286, de 5 de dezembro de 2007, que estabelece o Programa Saúde na Escola, e o aporte teórico. A partir do levantamento de teses e dissertações e de artigos científicos, percebeu-se o alcance das medidas educacionais tomadas pelo Estado brasileiro para promover a articulação intersetorial e universalizar o atendimento aos estudantes da rede escolar pública de educação básica por meio de ações de prevenção, promoção e atenção à saúde. Concluiu-se que as ações sugeridas nas pesquisas sobre o Programa Saúde na Escola podem contribuir para a formação integral e para a qualidade de vida do estudante, bem como pode colaborar com práticas de gestão que levem em consideração as potencialidades das ações intersetoriais previstas nesse programa. No entanto, esta investigação revelou a escassez de estudos científicos a respeito de pesquisas sobre as diferentes ações dispostas no Programa Saúde na Escola.
Uma análise dos últimos 20 anos dos protocolos da American Heart Association: O que mudou no Suporte Básico de Vida?
Authors: Duarte Alex Coelho da Silva , Chícharo Sandra Conceição Ribeiro , Silva Kelly Cristina Freitas da , Vianna Thaís Araujo , Oliveira Richardson Lemos de , Santana Wilder Kleber Fernandes de
Published: April 2021

Objetivo: Descrever as principais alterações no Suporte Básico de Vida – SBV ao longo dos 20 anos dos guidelines da American Heart Association de reanimação cardiopulmonar no adulto. Metodologia: Pesquisa qualitativa de natureza sócio-histórica dos guidelines publicados pela American Heart Association nos últimos 20 anos. O tratamento dos dados se deu por meio da análise de conteúdo. Resultados: Da análise dos documentos, foram observadas as seguintes mudanças: Algoritmo de ABCD para CAB em 2010; a frequência de compressão que passou, em 2015, a ser de no mínimo 100 e no máximo 120 por minuto; a profundidade da compressão que, no mesmo ano, passou a ser de no mínimo 5 cm e no máximo 6 cm, em adultos; a implantação da Compressão Cardíaca Contínua e; uma única relação compressão ventilação. Conclusão: É muito comum acompanharmos erros por falta de atualização dos protocolos, por isso uma educação permanente eficaz é fundamental para manter o profissional atualizado e consciente da justificativa da realização do procedimento. Assim, o conhecimento permite ao profissional um pensamento crítico, o que facilita a tomada de decisões.
Apercepção da violência institucional em sala de aula por discentes de uma Universidade Pública do Estado do Pará
Authors: Alves Sandra Maria da Conceição Moura , Silva Marcos Valério Santos da
Published: April 2021

O presente estudo aborda as possíveis ocorrências de práticas violentas manifestadas no espaço relacional da sala de aula cujo objetivo consiste em analisar a apercepção de discentes universitários sobre violência institucional apresentada em sala de aula e as repercussões em suas vidas. Estudou-se, ainda, a influência do fenômeno violência, em sala de aula, identificando-se as possíveis manifestações mais frequentes da violência, propondo-se, ainda, a gerar subsídios para realização de medidas de promoção e prevenção que favoreçam um ambiente de estudo e preparação profissional mais acolhedor e saudável. Realizou-se um estudo descritivo, de abordagem qualitativa, por meio de entrevista semiestruturada, com 20 discentes pertencentes a um programa de assistência psicossocial estudantil de uma instituição pública de ensino superior do Estado do Pará. Na análise dos dados aplicou-se a técnica da análise de conteúdo a partir de categorias emergidas das informações fornecidas pelos participantes da pesquisa. Verificou-se que a violência verbal apresenta-se, demasiadamente, marcante e expressiva, apesar de outras formas de manifestação também fazerem-se presentes. A relação discente-discente mostrou-se a mais afetada por atitudes/atos de violência, sendo essas manifestações violentas capazes de acarretar em impactos negativos diversos na vida dos discentes, em sua saúde física e emocional, bem como em seus estudos e relações com família e amigos. Conclui-se que a sala de aula no âmbito institucional universitário configura-se como um ambiente passível de se deflagrar violência, podendo conduzir a consequências nocivas à natureza humana.
RISK ASSESSMENT FOR WORK HEALTH AND SAFETY: A UNIVERSITY DINING HALL
Authors: ÖZDEMİR Kübra , ÖZDEMİR Ayşe
Published: April 2021

With the development of working life, work health and safety has become an area gaining great importance. Currently, the most important topics are preventing occupational diseases and work accidents that may occur in the working environment or due to working conditions, protecting the health of employed individuals and provided full well-being. Work health and safety compasses protecting the health and safety of employed individuals against psychological, biological, physical, chemical and ergonomic hazards. The dining hall sector involves intense work load, rapid growth and employment and is known for a large problem with increasing in work accidents. This research, performed with the aim of taking precautions to resolve problems in the dining hall sector in terms of work health and safety, performed a risk analysis to determine the hazards and risks in a university dining hall. Risk analysis assessed hazards and risks and determined precautions which should be taken. Additionally, it contributes to preserving the health of employed individuals and provides a reduction in work accidents and occupational diseases. This research performed risk analysis using a L-type matrix method. The hazards and risks present in the dining hall area were determined. The determined hazards and risks were grouped according to risk level and precautions for these were planned within the scope of the study. Efforts were made to contribute to ensuring a healthy working environment and improving safety conditions. Additionally, an important factor is considered to be adopting proactive approaches within the scope of work health and safety activities to popularize the work safety culture within working areas.
KEPUASAN PASIEN ANC DAN IMMUNISASI TERHADAP PENERAPAN APLIKASI PENDAFTARAN ONLINE BERBASIS ANDROID
Authors: Suryandari Endang Sri Dewi Hastuti
Published: April 2021

Pelayanan pendaftaran di BPM (Bidan Praktik Mandiri) Ovalya Makarova Kecamatan Pujon masih dilakukan secara manual yaitu dengan menggunakan buku register dan buku KIA pasien. Hal ini menyebabkan pasien menunggu antrian untuk mendapatkan pelayanan. Tujuan dari penelitian ini adalah untuk mengetahui tingkat kepuasan pasien dalam menggunakan aplikasi pendaftaran online berbasis android di BPM Ovalya Makarova  Kecamatan Pujon. Rancangan penelitian ini menggunakan Research and Development (R&D), dengan metode penelitian survei deskriptif. Variabel dari penelitian ini adalah aplikasi pendaftaran online berbasis android dan tingkat kepuasan pasien. Subjek penelitian adalah ibu hamil yang memeriksakan kehamilan (antenatal care) ataupun yang datang untuk mengimunisasikan bayi/balitanya sejumlah 59 pasien. Peneliti menggunakan bahasa pemrograman PHP dan HTML dengan menggunakan database MySQL untuk merancang aplikasi. Hasil dari uji fungsi aplikasi menggunakan uji blackbox adalah semua fungsi menu dan item aplikasi dinyatakan valid, sehingga aplikasi layak untuk digunakan. Edukasi telah dilakukan kepada pasien khususnya pasien imunisasi dan antenatal care. Hasil dari implementasi aplikasi pendaftaran online berbasis android dengan menggunakan kuesioner kepuasan didapatkan rata-rata skor 3,01 yang berarti bahwa pasien menyatakan puas dalam menggunakan aplikasi. Maka dapat disimpulkan bahwa aplikasi pendaftaran online berbasis android dapat mempermudah pasien dalam melakukan proses pendaftaran di BPM Ovalya Makarova Kecamatan Pujon. Perlunya perbaikan dan pengembangan aplikasi yang dapat dilakukan oleh peneliti lain, seperti menu tambahan pada aplikasi pendaftaran online berbasis android.
Pengetahuan Keluarga Pasien Tuberkulosis Sebagai Upaya Penyembuhan dan Penurunan Angka Kejadian Tuberkulosis
Authors: Sumiati Eti
Published: April 2021

Tuberculosis is an infectious disease of the respiratory tract and other organs caused by the Mycobacterium tuberculosis bacteria. Tuberculosis (TB) is still one of the causes of high morbidity and mortality in the world. Indonesia is among the five countries with the highest incidence of cases. Patient adherence to medication is an important factor in the success of a treatment, and will increase the overall cure rate. The cure rate for TB patients can be influenced by several things, which one is family support, so that family knowledge of TB disease experienced by patients is very important.  The aimed of this research to know the description of the patient's family knowledge about tuberculosis. This research is descriptive using data collection tools in the form of questionnaires as primary data and patient medication cards as secondary data using convenience sampling method. The subjects in the study were family members of pulmonary and extrapulmonary tuberculosis patients without complications and without MDR who were undergoing treatment for the period January-March 2019 at the Kediri Public Health Center. The results showed that as many as 11 respondents had high / good knowledge and as many as 9 respondents had low/poor knowledge.
Profil Karakteristik Individu Terhadap Kejadian Hiperuresemia
Authors: Arsa Putu Sintya Arlinda
Published: April 2021

Abstrak

Pendahuluan Hiperuresemia merupakan peningkatan kadar asam urat pada darah. Prevalensi hiperuresemia mengalami peningkatan. Gout merupakan gangguan metabolik yang ditandai dengan peningkatan kadar asam urat (hiperuresemia). Hiperuresemia jika tidak ditangani dengan tepat maka dapat dapat mengancam nyawa manusia. Tujuan dari penelitian ini adalah mengetahui gambaran kejadian hiperuresemia pada warga di RT 02 RW 03 Kelurahan Arjosari Kecamatan Blimbing Kota Malang. Data yang diteliti adalah jenis kelamin, usia, pendidikan, pekerjaan dan pendapatan. Metode penelitian yang digunakan design penelitian observasi analitik cross sectional, pengambilan data dilakukan dengan wawancara dan pengukuran kadar asam urat dalam darah melalui metode test stick kadar asam urat darah. Teknik pengambilan sampel menggunakan Simple Random Sampling dengan jumlah sampel 50 responden. Hasil penelitian didapatkan karakteristik responden berdasarkan jenis kelamin perempuan lebih besar 68,4 %, karakteristik usia sebagian besar berusia 50-59 tahun dengan persentase 42,1%, karakteristik responden berdasarkan pendidikan berasal jenjang perguruan tinggi sebesar 36,8 %, karakteristik responden berdasarkan jenis pekerjaan sebagian besar tidak bekerja/IRT sebesar 52,6% dan karakteristik responden berdasarkan pendapatan sebesar  >2.000.000 perbulan dengan persentase  42,1 %.  Kesimpulan Hasil penelitian ini  diharapkan mampu dijadikan kebijakan kesehatan masyarakat untuk selalu menerapkan pola makan yang sehat, diet rendah purin, dan rutin berolahraga.

 

Kata Kunci: Hiperuresemia; Asam urat; Karakteristik individu
PENURUNAN STRESS PADA LANSIA DENGAN RELAKSASI BENSON
Authors: Rokhman Abdul
Published: April 2021

Angka harapan hidup yang tinggi meningkatkan populasi lansia. Namun lansia sering mengalami beberapa masalah akibat perubahan fisik yang terjadi, salah satunya stres. Upaya penanganan yang bisa dilakukan yaitu dengan relaksasi Benson salah satunya. Penelitian ini bertujuan untuk menganalisis pengaruh relaksasi Benson terhadap stres pada lansia. Penelitian ini menggunakan desain quasy eksperimental one group pre-posttest dengan jumlah sampel sebanyak 30 orang lansia, uji analisis menggunakan uji wilcoxon dengan signifikansi 0,05. Hasil penelitian diperoleh nilai median skor stres lansia sebelum melakukan relaksasi Benson yaitu 20, dan setelah lansia melakukan relaksasi Benson nilai median skor stres lansia mengalami penurunan menjadi 16 dengan nilai p = 0,000. Hal itu menunjukkan jika ada pengaruh relaksasi Benson terhadap stres pada lansia. Relaksasi Benson terbilang efektif dalam menurunkan stres lansia dengan memberikan rasa rileks yang terjadi. Relaksasi Benson dapat disarankan menjadi salah satu pilihan terapi untuk stres pada lansia.
ANALISIS PENGARUH ANGKA HARAPAN LAMA SEKOLAH, RATA-RATA LAMA SEKOLAH, DAN PENGELUARAN PER KAPITA TERHADAP INDEKS PEMBANGUNAN MANUSIA DI PROVINSI JAWA TENGAH
Authors: Mahya A. Jauhar
Published: April 2021

The Human Development Index (HDI) is one of the data and information used by local governments to measure the achievement of human development. HDI is formed by three basic dimensions, namely a long and healthy life, knowledge, and a decent standard of living. This study explain whether there is an influence and to obtain the magnitude of the influence of the expected number of years of schooling, the average length of schooling, and the per capita expenditure together on the Human Development Index in Central Java Province. This study was completed using multiple linear regression analysis with the help of SPSS 1.6 (Statistical Package for Social Sciences) software. The results of this study indicate that the expected length of schooling, average length of schooling, and per capita expenditure have a significant effect on the human development index, which is 97.8% and only 2.2% is influenced by other factors.
In vitro antiproliferative and antiangiogenic effects of Flavin7®
Authors: Mojžiš J , Šarišský M , Pilátová M , Voharová V , Varinská L , Mojžišová G , Ostro A , Urdzík P , Dankovčk R , Mirossay L
Published: April 2021

Flavin7 (F7) is a nutritional supplement often taken by cancer
patients in Central Europe during chemo- and radiation therapy.
In this study, investigation of the antiproliferative and
antiangiogenic activities of this supplement were performed.
Flavin7 showed antiproliferative activity in Jurkat as well as in
HeLa cells. It significantly reduced the growth of both cancer cell
lines at the doses of 200 μg/ml to 20 μg/ml (p<0.001 and
p<0.01, respectively). In F7-treated Jurkat cells we found a
significant increase in the fraction of cells with sub-G0/G1 DNA
content, which is considered to be a marker of apoptotic cell
death. Apoptosis was also confirmed by annexin V staining and
DNA fragmentation. Furthermore, F7 at the doses of 100 μg/ml
to 4 μg/ml inhibited endothelial cell migration and capillary tube
formation what indicates its potential antiangiogenic properties.
Flavin7 also inhibited the activity of matrix metalloproteinases
(MMPs), preferentially MMP-9, at the doses of 100 μg/ml to
4 μg/ml. Our data suggest that F7 possesses marked
antiproliferative and antiangiogenic properties in vitro. Further
research is needed to elucidate also its in vivo activities.
Hypertension in spontaneously hypertensive rats occurs despite low plasma levels of homocysteine
Authors: Kondziella D , Zetterberg H , Haugen E , Fu M
Published: April 2021

Hyperhomocysteinemia has been suggested to induce
hypertension due to its role in endothelial dysfunction. However,
it remains controversial whether homocysteine and hypertension
are truly causally related or merely loosely associated. To test the
hypothesis that hyperhomocysteinemia occurs in spontaneously
hypertensive rats (SHR) we measured plasma levels of
homocysteine in 10 male adult SHR and in 10 normotensive
controls using ion exchange chromatography. In addition, plasma
concentrations of the 22 most common amino acids were
measured to explore the relation of homocysteine with amino
acid metabolism. Plasma levels of homocysteine were
significantly lower in SHR (4.1±0.1 µmol/l) than in controls (7.2±
0.3 µmol/l) (p<0.00001). The amounts of aminobutyric acid,
alanine, citrulline and valine were also decreased, whereas we
found increased levels of aspartate, glutamate, glutamine,
histidine and ornithine. Thus, contrary to our hypothesis,
hypertension in SHR occurs despite low plasma levels of
homocysteine. We provide a new hypothesis whereby reduced
conversion of arginine to citrulline is related to increased
ornithine levels, but decreased bioavailability of nitric oxide,
resulting in impaired blood vessel relaxation and hypertension. In
conclusion, our findings do not necessarily exclude that
homocysteine and hypertension might be pathophysiologically
connected, but corroborate the notion that hypertension can
arise due to mechanisms independent of high homocysteine
levels.
Late blood pressure reduction in shr subjected to transient captopril treatment in youth: possible mechanisms
Authors: Zicha J , Dobešová Z , Kuneš J
Published: April 2021

Spontaneously hypertensive rats (SHR) are characterized by
enhanced nifedipine-sensitive component of sympathetic
vasoconstriction. Our study tried to elucidate the mechanisms
responsible for long-term reduction of blood pressure (BP) in SHR
subjected to early transient captopril treatment. Adult untreated
SHR aged 30-34 weeks were compared with animals subjected to
chronic captopril treatment for 6 weeks either in youth (between
4 and 10 weeks of age) or in adulthood (between 24 and 30
weeks of age). Antihypertensive effects of captopril were more
pronounced in young than adult SHR. This was due to greater
attenuation of sympathetic and nifedipine-sensitive BP
components and prevention of residual BP rise in young
captopril-treated SHR in which the reductions of nifedipinesensitive BP component and residual BP persisted for 20 weeks
after captopril withdrawal. The magnitude of nifedipine-sensitive
component of sympathetic vasoconstriction is decisive for BP
maintenance not only in untreated SHR but also in SHR during
active captopril treatment by or after its withdrawal.
Prioritizing Entrepreneurship and Startup Culture Through Policy Intervention as A Strategy for Economy Recovery
Authors: BHATTARAİ Hemlal
Published: April 2021

World today is going through a difficult phase as consequences of COVID-19 pandemic. There is an evidence of the world economy being hit hard and a case of economic recession which created significant threats to the social and economical welfare of the society. Needs are felt to focus on prioritizing entrepreneurship and startup culture as these are the backbones of any economy. But on the other hand, entrepreneurship and the startups growth and sustainability themselves are greater threats ats current times. There is a need for immediate interventions through approaches that are conducive, if erase please the critical role of entrepreneurship and startups are desired to be developed in order to sustain the revival of our economy. This can only be materialized through right understanding of entrepreneurial ecosystems as general and in the scurrent times through researches so that right and meaningful interventions can be made. This study focuses on making policy intervention approaches as a key strategy to provide a favorable platform for startups to grow as well as existing entrepreneurs to sustain. To supplement this study, the data from primary resources are utilized and a methodological approach drawn highlighting the strong nexus between i) Strategies to foster entrepreneurship, ii) Entrepreneurial Ecosystem and iii) SWOT analysis. These three indices can be handy in materializing the meaningful interventions that create conducive platforms for entrepreneurship and startups thereby making a positive impact to the social as well as economical welfare of the society. With unpredictable nature of current pandemic and the series of its associated impacts, there are needs for continuous and innovative engagement in research through global perspectives.
EU Non-Intentional Geopolitics and The “Europeanisation” of Strategic - Operative Functions: Mare Nostrum and Triton Missions as a Test of EU Political Capability
Authors: JELEN Igor , BENEDETTI Elisabetta , SPECOGNA Erica
Published: April 2021

European integration started in different contexts, after the World War II, as an answer to contingent tensions, but also as the realization of a project elaborated in the centuries by idealists of different derivation. Its main aim would be that of overcoming rivalries that often brought the different contiguous counties to fighting each other in desperate but non-sense wars. Such kind of tensions, the continent is periodically exposed to, need to be managed, requiring for the EU the challenge of a further step in the integration, namely the formation of some operative device, capable of facing the different risks, that may appear suddenly at strategic and geo-political scale. It is the case, recently, of mass immigration, that need to be faced with in a new way, considering security, but also human and wider civil implications.
MANAJEMEN RISIKO KESEHATAN DAN KESELAMATAN KERJA (K3) Studi Kasus Pada Praktek Acuan Perancah Dan Praktek Kayu Jurusan Teknik Sipil
Authors: Udi Subagyo
Published: April 2021

Politeknik Negeri Malang adalah lembaga pendidikan profesional dalam jaringan pendidikan global dengan reputasi di bidang ilmu pengetahuan dan teknologi terapan, dalam hal tersebut jurusan teknik Sipil mempunyai kegiatan praktek kerja bengkel yang menunjang skill mahasiswa untuk dunia konstruksi. Oleh karena pekerjaan praktek acuan dan perancah dan praktek kerja kayu juga mengandung unsur unsur bahaya pekerjaan maka diperlukan Manajemen Risiko Kesehatan Dan Keselamatan Kerja (K3). Hasil manajemen resiko pada praktek acuan & perancah terdapat 16 potensi bahaya risiko dari 5 proses kegiatan dengan potensi bahaya cukup besar adalah : Orang Jatuh 25% , dengan pekerjaan High Risk pada pekerjaan Scafolding 70%, dengan rekomendasi Penggunaan APD 85%, Eliminasi 29%,Engineering Control 29%, Tanda Peringatan,label & administrasi 28% dan Substitusi 19%. Dan pada praktek pekerjaan kayu terdapat 15 potensi bahaya risiko dari 3 proses kegiatan dengan potensi bahaya cukup besar adalah : Bising 21% , dengan pekerjaan High Risk pada pekerjaan pekerjaan Kayu menggunakan Mesin Statis 85% dengan rekomendasi Penggunaan APD 94%,Engineering Control 67%,Substitusi 14%,Tanda Peringatan,label & administrasi 7% dan Eliminasi 7%.
Geopolitical Inhomogeneities in the Registered Voters’ Distribution and Their Influence in the Voters’ Participation Ratio Distribution: The Mexican Case
Authors: Hernández-Saldaña H.
Published: April 2021

Stylized facts appear in electoral processes worldwide, from Brazil to India. Here, we update a statistics carried on in Mexican elections but considering the inhomogeneities in electoral districts through the Nominal List (NL) (the list of valid electors in a given decision process) for the last three presidential elections. We find that the NL distribution at polling station detail is composed of, at least, three windows with a step function structure. Next, we study the consequences of the windows structure for the statistical properties of the processes. We obtain that the asymmetric vote distribution by polling station recovers a Gaussian shape for two of the windows; meanwhile, the standardized distribution of votes follows a distorted Gaussian, near to a skew normal. The distribution of the turnout at each polling station or voters’ participation ratio is close to a skew normal one in the bulk and failing at the wings. The average of voters increases in a linear way with the Nominal List and depends on the window considered. The results do not depend on the municipality, political district or urban versus nonurban distinction, and the electoral process considered.
Bioengineering the Bone Marrow Vascular Niche
Authors: Bessy Thomas , Itkin Tomer , Passaro Diana
Published: April 2021

The bone marrow (BM) tissue is the main physiological site for adult hematopoiesis. In recent years, the cellular and matrix components composing the BM have been defined with unprecedent resolution, both at the molecular and structural levels. With the expansion of this knowledge, the possibility of reproducing a BM-like structure, to ectopically support and study hematopoiesis, becomes a reality. A number of experimental systems have been implemented and have displayed the feasibility of bioengineering BM tissues, supported by cells of mesenchymal origin. Despite being known as an abundant component of the BM, the vasculature has been largely disregarded for its role in regulating tissue formation, organization and determination. Recent reports have highlighted the crucial role for vascular endothelial cells in shaping tissue development and supporting steady state, emergency and malignant hematopoiesis, both pre- and postnatally. Herein, we review the field of BM-tissue bioengineering with a particular focus on vascular system implementation and integration, starting from describing a variety of applicable in vitro models, ending up with in vivo preclinical models. Additionally, we highlight the challenges of the field and discuss the clinical perspectives in terms of adoptive transfer of vascularized BM-niche grafts in patients to support recovering hematopoiesis.
β-Arrestin1 Promotes Colorectal Cancer Metastasis Through GSK-3β/β-Catenin Signaling- Mediated Epithelial-to-Mesenchymal Transition
Authors: Song Qing , Han Zhifen , Wu Xinnan , Wang Yan , Zhou Lihong , Yang Liu , Liu Ningning , Sui Hua , Cai Jianfeng , Ji Qing , Li Qi
Published: April 2021

Recurrence and metastasis seriously affects the prognosis of patients with tumors, and the epithelial-to-mesenchymal transition (EMT) plays a key role in promoting tumor invasion and metastasis. Previous studies have showed that β-arrestin1 acted as a tumor-promoting factor in multiple types of tumor. However, the exact role and mechanism of β-arrestin1 in colorectal cancer (CRC) progression remains to be elucidated. Our research aimed to explore the potential mechanism underlying the role of β-arrestin1 in CRC metastasis. The expression of β-arrestin1 was investigated in both primary and metastatic CRC tissues using the GSE41258 database, and it was revealed that CRC patients with liver/lung metastasis had a higher expression level of β-arrestin1, and the expression level of β-arrestin1 was inversely correlated with the prognosis of CRC patients. Further in vitro mechanism studies indicated that β-arrestin1 had the ability to promote the migration of CRC cells through regulating the EMT process by activating Wingless/integration-1 (Wnt)/β-catenin signaling pathways. Blocking Wnt/β-catenin signaling with inhibitor ICG001 decreased the promoting effect of β-arrestin1 on EMT in CRC. In vivo imaging experiments further demonstrated the promoting effect of β-arrestin1 on the lung metastasis of CRC cells by tail vein injection in mice. The results of this paper suggest that β-arrestin1 promotes EMT via Wnt/β-catenin signaling pathway in CRC metastasis, and provides a novel therapeutic target for CRC metastasis.
A Review of CXCL1 in Cardiac Fibrosis
Authors: Wu Cheng-Long , Yin Ran , Wang Su-Nan , Ying Ru
Published: April 2021

Chemokine C-X-C motif ligand-1 (CXCL1), principally expressed in neutrophils, macrophages and epithelial cells, is a valid pro-inflammatory factor which performs an important role in mediating the infiltration of neutrophils and monocytes/macrophages. Elevated serum level of CXCL1 is considered a pro-inflammatory reaction by the organism. CXCL1 is also related to diverse organs fibrosis according to relevant studies. A growing body of evidence suggests that CXCL1 promotes the process of cardiac remodeling and fibrosis. Here, we review structure and physiological functions of CXCL1 and recent progress on the effects and mechanisms of CXCL1 in cardiac fibrosis. In addition, we explore the role of CXCL1 in the fibrosis of other organs. Besides, we probe the possibility that CXCL1 can be a therapeutic target for the treatment of cardiac fibrosis in cardiovascular diseases.
Identification of Novel Biomarkers for Pre-diabetic Diagnosis Using a Combinational Approach
Authors: Yang Meng-Ting , Chang Wei-Hung , Kuo Tien-Fen , Shen Ming-Yi , Yang Chu-Wen , Tien Yin-Jing , Lai Bun-Yueh , Chen Yet-Ran , Chang Yi-Cheng , Yang Wen-Chin
Published: April 2021

Reliable protein markers for pre-diabetes in humans are not clinically available. In order to identify novel and reliable protein markers for pre-diabetes in humans, healthy volunteers and patients diagnosed with pre-diabetes and stroke were recruited for blood collection. Blood samples were collected from healthy and pre-diabetic subjects 12 h after fasting. BMI was calculated from body weight and height. Fasting blood glucose (FBG), glycated hemoglobin (HbA1C), triglyceride (TG), total cholesterol, high-density lipoprotein, low-density lipoprotein (LDL), insulin and albumin were assayed by automated clinical laboratory methods. We used a quantitative proteomics approach to identify 1074 proteins from the sera of pre-diabetic and healthy subjects. Among them, 500 proteins were then selected using Mascot analysis scores. Further, 70 out of 500 proteins were selected via volcano plot analysis according to their statistical significance and average relative protein ratio. Eventually, 7 serum proteins were singled out as candidate markers for pre-diabetes due to their diabetic relevance and statistical significance. Immunoblotting data demonstrated that laminin subunit alpha 2 (LAMA2), mixed-lineage leukemia 4 (MLL4), and plexin domain containing 2 (PLXDC2) were expressed in pre-diabetic patients but not healthy volunteers. Receiver operating characteristic curve analysis indicated that the combination of the three proteins has greater diagnostic efficacy than any individual protein. Thus, LAMA2, MLL4 and PLXDC2 are novel and reliable serum protein markers for pre-diabetic diagnosis in humans.
TGFβ1: An Indicator for Tumor Immune Microenvironment of Colon Cancer From a Comprehensive Analysis of TCGA
Authors: Wang Jinyan , Wang Jinqiu , Gu Quan , Yang Yan , Ma Yajun , Zhang Quan’an
Published: April 2021

Background

Tumor microenvironment (TME) and tumor-infiltrating immune cells (TICs) greatly participate in the genesis and development of colon cancer (CC). However, there is little research exploring the dynamic modulation of TME.

Methods

We analyzed the proportion of immune/stromal component and TICs in the TME of 473 CC samples and 41 normal samples from The Cancer Genome Atlas (TCGA) database through ESTIMATE and CIBERSORT algorithms. Correlation analysis was conducted to evaluate the association between immune/stromal component in the TME and clinicopathological characteristics of CC patients. The difference analysis was performed to obtain the differentially expressed genes (DEGs). These DEGs were further analyzed by GO and KEGG enrichment analyses, PPI network, and COX regression analysis. Transforming growth factor β1 (TGFβ1) was finally overlapped from the above analysis. Paired analysis and GSEA were carried out to understand the role of TGFβ1 in colon cancer. The intersection between the difference analysis and correlation analysis was conducted to learn the association between TGFβ1 and TICs.

Results

Our results showed that the immune component in the TME was negatively related with the stages of CC. GO and KEGG enrichment analysis revealed that 1,110 DEGs obtained from the difference analysis were mainly enriched in immune-related activities. The intersection analysis between PPI network and COX regression analysis indicated that TGFβ1 was significantly associated with the communication of genes in the PPI network and the survival of CC patients. In addition, TGFβ1 was up-regulated in the tumor samples and significantly related with poor prognosis of CC patients. Further GSEA suggested that genes in the TGFβ1 up-regulated group were enriched in immune-related activities and the function of TGFβ1 might depend on the communications with TICs, including T cells CD4 naïve and T cells regulatory.

Conclusion

The expression of TGFβ1 might be an indicator for the tumor immune microenvironment of CC and serve as a prognostic factor. Drugs targeting TGFβ1 might be a potential immunotherapy for CC patients in the future.