bluuebunny/crossref_metadata_2025 huggingface dataset:
β-Cell–Specific E2f1 Deficiency Impairs Glucose Homeostasis, β-Cell Identity, and Insulin Secretion
Authors: Oger Frédérik , Bourouh Cyril , Friano Marika Elsa , Courty Emilie , Rolland Laure , Gromada Xavier , Moreno Maeva , Carney Charlène , Rabhi Nabil , Durand Emmanuelle , Amanzougarene Souhila , Berberian Lionel , Derhourhi Mehdi , Blanc Etienne , Hannou Sarah Anissa , Denechaud Pierre-Damien , Benfodda Zohra , Meffre Patrick , Fajas Lluis , Kerr-Conte Julie , Pattou François , Froguel Philippe , Pourcet Benoit , Bonnefond Amélie , Collombat Patrick , Annicotte Jean-Sébastien
Published: May 2023

The loss of pancreatic β-cell identity has emerged as an important feature of type 2 diabetes development, but the molecular mechanisms are still elusive. Here, we explore the cell-autonomous role of the cell-cycle regulator and transcription factor E2F1 in the maintenance of β-cell identity, insulin secretion, and glucose homeostasis. We show that the β-cell–specific loss of E2f1 function in mice triggers glucose intolerance associated with defective insulin secretion, altered endocrine cell mass, downregulation of many β-cell genes, and concomitant increase of non–β-cell markers. Mechanistically, epigenomic profiling of the promoters of these non–β-cell upregulated genes identified an enrichment of bivalent H3K4me3/H3K27me3 or H3K27me3 marks. Conversely, promoters of downregulated genes were enriched in active chromatin H3K4me3 and H3K27ac histone marks. We find that specific E2f1 transcriptional, cistromic, and epigenomic signatures are associated with these β-cell dysfunctions, with E2F1 directly regulating several β-cell genes at the chromatin level. Finally, the pharmacological inhibition of E2F transcriptional activity in human islets also impairs insulin secretion and the expression of β-cell identity genes. Our data suggest that E2F1 is critical for maintaining β-cell identity and function through sustained control of β-cell and non–β-cell transcriptional programs.

Article Highlights

β-Cell–specific E2f1 deficiency in mice impairs glucose tolerance. Loss of E2f1 function alters the ratio of α- to β-cells but does not trigger β-cell conversion into α-cells. Pharmacological inhibition of E2F activity inhibits glucose-stimulated insulin secretion and alters β- and α-cell gene expression in human islets. E2F1 maintains β-cell function and identity through control of transcriptomic and epigenetic programs.
Astrocyte Glycogen Is a Major Source of Hypothalamic Lactate in Rats With Recurrent Hypoglycemia
Authors: Su Gong , Farhat Rawad , Laxman Anil K. , Chapman-Natewa Kimberly , Nelson Irvane E. , Chan Owen
Published: May 2023

Lactate is an important metabolic substrate for sustaining brain energy requirements when glucose supplies are limited. Recurring exposure to hypoglycemia (RH) raises lactate levels in the ventromedial hypothalamus (VMH), which contributes to counterregulatory failure. However, the source of this lactate remains unclear. The current study investigates whether astrocytic glycogen serves as the major source of lactate in the VMH of RH rats. By decreasing the expression of a key lactate transporter in VMH astrocytes of RH rats, we reduced extracellular lactate concentrations, suggesting excess lactate was locally produced from astrocytes. To determine whether astrocytic glycogen serves as the major source of lactate, we chronically delivered either artificial extracellular fluid or 1,4-dideoxy-1,4-imino-d-arabinitol to inhibit glycogen turnover in the VMH of RH animals. Inhibiting glycogen turnover in RH animals prevented the rise in VMH lactate and the development of counterregulatory failure. Lastly, we noted that RH led to an increase in glycogen shunt activity in response to hypoglycemia and elevated glycogen phosphorylase activity in the hours following a bout of hypoglycemia. Our data suggest that dysregulation of astrocytic glycogen metabolism following RH may be responsible, at least in part, for the rise in VMH lactate levels.

Article Highlights

Astrocytic glycogen serves as the major source of elevated lactate levels in the ventromedial hypothalamus (VMH) of animals exposed to recurring episodes of hypoglycemia. Antecedent hypoglycemia alters VMH glycogen turnover. Antecedent exposure to hypoglycemia enhances glycogen shunt activity in the VMH during subsequent bouts of hypoglycemia. In the immediate hours following a bout of hypoglycemia, sustained elevations in glycogen phosphorylase activity in the VMH of recurrently hypoglycemic animals contribute to sustained elevations in local lactate levels.
AN ANALISYS OF COMMUNITY EMPOWERMENT ON THE SME MITRA UMAT PROGRAM OF LEMBAGA AMIL ZAKAT BANGUN SEJAHTERA MITRA UMAT (LAZNAS BSM UMAT)
Authors: Felita Safira , Muhtadi Muhtadi
Published: May 2023

Community development through productive zakat could improve the economic state of mustahiks, particularly those with Small and Medium Enterprises (SMEs). This study aims to: (1) learn about the LAZNAS BSMU community development scheme; (2) understand the benefits and drawbacks of the Mitra Umat SME program. This study employs a qualitative approach with descriptive evaluative methods. Field research data collection techniques include observation, interviews, and documentation. According to the findings of this study: (1) Mitra Umat team from LAZNAS BSMU accomplished their program so well and managed productive zakat as it should and precisely through Mitra Umat SME program for the mustahiks who joined and participated in the program; (2) The mechanism of development done by Mitra Umat team LAZNAS BSMU suitable according to the theory of community development; and (3) Mitra Umat SME program based on productive zakat could give a good impact and welfare.
La Plaza Mayor de Málaga en el siglo XVI
Authors: Aguilar María Dolores
Published: May 2023

Málaga, como muchas otras ciudades, en el siglo XVI no posee un urbanismo renacentista propiamente dicho, que supone un orden geométrico en su conjunto, en plantas y alzados.
La pintura costumbrista del siglo XIX en Málaga
Authors: Palomo Díaz Francisco J.
Published: May 2023

Es un pasaje de lLas vestiduras recamadas de Salvador González Anaya se encuentran en animada charla dos de los protagonistas principales.
Ciudades de cine
Authors: Reseña de Adolfo Carratalá Francisco García Gómez, Gonzalo M. Pavés (coords.).
Published: May 2023

Reseña del libro Ciudades de cine.
Ocena wskaźników przydatności opasowej i jakości rzeźnej jałowic towarowych po buhajach rasy limousine
Authors: Stanek Piotr , Januś Ewa , Żółkiewski Paweł
Published: May 2023

Celem pracy była ocena wskaźników przydatności opasowej i wartości rzeźnej 53 jałówek mieszańców phf cb z rasą limousine żywionych półintensywnie. Uzyskane wyniki w zakresie przyrostów dobowych, wieku uboju, masy ubojowej, masy tuszy ciepłej i jej wydajności oraz uformowania i otłuszczenia tusz analizowano w zależności od systemu utrzymania, udziału genów rasy limousine, masy urodzeniowej i masy ciała po zakończeniu opasu. Stwierdzono, że jałówki o 75% udziale genów limousine osiągnęły najwyższą masę ubojową i masę tuszy oraz najlepsze umięśnienie i największe otłuszczenie. Większą masą tuszy ciepłej i lepszym umięśnieniem charakteryzowały się jałowice utrzymywane bez uwięzi. Z kolei tusze jałowic utrzymywanych luzem charakteryzowały się istotnie (P ≤ 0,05) większym otłuszczeniem (11,53 pkt, klasa 4–) w porównaniu ze zwierzętami utrzymywanymi na uwięzi (10,32 pkt, klasa 4), jak również uzyskiwały istotnie (P ≤ 0,05) większą wydajność rzeźną (61,2% vs. 60,2%). Stwierdzono, że jałówki o większej masie urodzeniowej uzyskiwały istotnie (P ≤ 0,05) większą masę ubojową.
Przeprowadzona analiza wykazała, że oceniane jałówki uzyskały średnią masę ubojową ponad 475 kg w ciągu 20 miesięcy. W klasyfikacji EUROP ich tusze zostały ocenione na U i R. Ponadto odznaczały się wysoką wydajnością rzeźną wynoszącą ponad 60 % przy otłuszczeniu tuszy w klasie 3 i 4 (klasy otłuszczenia EUROP).
Pokrzywa jako funkcyjny dodatek do żywności, suplementów diety i kosmetyków
Authors: Wajs Joanna , Stobiecka Magdalena , Brodziak Aneta , Król Jolanta
Published: May 2023

Stale rosnący trend zdrowego stylu życia oraz znaczny postęp technologii spożywczej oraz kosmetycznej skłania producentów do zwiększania funkcjonalności kreowanych produktów. Zarówno żywność, suplementy diety, jak i kosmetyki na bazie lub z dodatkiem pokrzywy zwyczajnej (Urtica dioica L.), zaliczanej do superfoods, posiadają wysoką wartość użytkową oraz szereg właściwości wspomagających zdrowie. Właściwości te niewątpliwie wynikają z obecności związków biologicznie aktywnych. Jako naturalna forma fortyfikacji wielu produktów, pokrzywa należy do ziół o silnych właściwościach przeciwzapalnych, przeciwutleniających czy immunostymulujących. W sektorze spożywczym występuje głównie w produktach takich jak miód, ciastka, herbata lub sok, a także w suplementach diety. W sektorze kosmetycznym pokrzywa jest komponentem szamponów, ale także maseczek czy peelingów. Ukierunkowanie konsumentów na produkty oparte o naturalne składniki a producentów na wykorzystanie potencjału substancji bioaktywnych zawartych w roślinach wpływa bezpośrednio na wykorzystanie surowców naturalnych, w tym pokrzywy, jako komponentów szerokiej gamy produktów dostępnych na rynku.
Impact of socialization on the possibility to conduct behavioral tests in sheep
Authors: Janicka Kamila , Sokołowski Jacek
Published: May 2023

The aim of the study was to assess the impact of socialization with humans on the possibility to conduct tests evaluating problem-solving in sheep. The research included 30 Świniarka sheep aged from 2 to 8 years. The sheep were kept in the barn-pasture system. The observations included three trials carried out on three consecutive days for each sheep. The behavior of the sheep, i.e. exploration and approach to equipment elements of the test arena, was analyzed. The experiment was conducted on groups of sheep with low (G1) and high (G2) levels of socialization. The study showed that the test environment was challenging for the G1 sheep, so they were unable to complete the task successfully.
Age at gonadectomy, sex, and breed size affect risk of canine overweight and obese outcomes: a retrospective cohort study using data from United States primary care veterinary clinics
Authors: Benka Valerie A. , Scarlett Janet M. , Sahrmann John , Rieke Katherine , Briggs Joyce R. , Ruple Audrey , Zawistowski Stephen , Morrison Jo Ann , Spofford Nathaniel , Romagnoli Stefano
Published: May 2023

OBJECTIVE

To examine the risk of developing an overweight or obese (O/O) body condition score (BCS) in gonadectomized versus intact dogs and, separately, the impact of age at gonadectomy on O/O outcomes among sterilized dogs.

ANIMALS

Dogs were patients of Banfield Pet Hospital in the US from 2013 to 2019. After exclusion criteria were applied, the final sample consisted of 155,199 dogs.

PROCEDURES

In this retrospective cohort study, Cox proportional hazards models evaluated associations between O/O and gonadectomy status, sex, age at gonadectomy, and breed size. Models were used to estimate the risk of becoming O/O in gonadectomized versus intact dogs and, separately, to estimate risk of O/O BCS according to age at surgery among gonadectomized dogs.

RESULTS

Gonadectomy increased O/O risk for most dogs compared to intact dogs. Unlike most prior findings, O/O hazard ratios among gonadectomized versus intact dogs were larger for males than females. O/O risk varied according to breed size but not linearly. Sterilizing at 1 year old tended to yield a lower O/O risk compared to doing so later. Comparative O/O risk among dogs gonadectomized at 6 months versus 1 year varied by breed size. Overall patterns for obesity related to size were similar to patterns in the O/O analysis.

CLINICAL RELEVANCE

Veterinarians are uniquely positioned to help prevent O/O in their patients. Results extend understanding of risk factors for O/O development in dogs. In combination with information about other benefits and risks associated with gonadectomy, these data can help tailor recommendations regarding gonadectomy in individual dogs.
Retrospective evaluation of wobbly hedgehog syndrome in 49 African pygmy hedgehogs (Atelerix albiventris): 2000–2020
Authors: Gonzalez Gabriela A. , Balko Julie A. , Sadar Miranda J. , Alexander Amy B. , Sheldon Julie D. , Doss Grayson A. , Keller Krista A. , Gardhouse Sara M. , Petritz Olivia A.
Published: May 2023

OBJECTIVE

To retrospectively evaluate the prevalence and clinical progression of wobbly hedgehog syndrome (WHS) and concurrent incidence of neoplasia in a cohort of African pygmy hedgehogs (Atelerix albiventris).

ANIMALS

49 hedgehogs.

CLINICAL PRESENTATION AND PROCEDURES

Medical records of hedgehogs from 7 institutions across the US over a 20-year period (2000 to 2020) were retrospectively reviewed. Inclusion criteria were hedgehogs of any sex or age with postmortem CNS histopathology consistent with WHS. Collected data included sex, age at onset and euthanasia, major histopathologic findings, reported neurologic clinical signs, and treatments administered.

RESULTS

24 males and 25 females were included. Fifteen of 49 (31%) individuals had subclinical WHS with no reported antemortem neurologic clinical signs. In neurologically affected (clinical) hedgehogs (n = 34), the mean ± SD age at onset was 3.3 ± 1.5 years with a median (range) time from onset to euthanasia of 51 days (1 to 319 days). In neurologically affected hedgehogs, the most commonly reported clinical signs were ataxia (n = 21) and pelvic limb paresis (16) and the most commonly administered treatment was meloxicam (13). Overall, 31 of 49 (63%) hedgehogs had a concurrent histopathologic diagnosis of neoplasia outside of the CNS.

CLINICAL RELEVANCE

The prognosis for hedgehogs with WHS is poor. No treatment had a significant effect on survival time, and neoplasia was a common comorbidity in the current cohort. A small but clinically relevant subset of neurologically normal hedgehogs had a histopathologic diagnosis of WHS.
Consent to Treatment and Anamnesis as Problem of Communication with Minor Patients in Healthcare Decision-Making
Authors: Palkova Karina , Semaka Svetlana
Published: May 2023

Lately lawyers and medical professionals pay more attention too the process of minor patient healthcare. The research shall address the issues of legal relationship between minor patients and medical professionals, consent to treatment of minor patients and communication problems including the scope of information which the doctor can provide to the minor patient’s relatives to protect themselves and patients. Legislation prescribes that the information provided by the medical professional to the minor patient must be not only easy-to-understand, but also be consistent with the patient’s age maturity. However, in Latvia, for example, there are no guidelines that specify how medical professionals can determine the patient’s maturity. In the course of provision of medical services to the minor persons legal disputes involving communiucation failures between the minor patients, their relatives, legal representatives and the doctors arise increasingly frequently. The research will look into issue of communication problems in healthcare. The aim of the research is to provide insight into challenges of legal relations betweem minor patients and medical professionals and communication problems in healthcare.
Therapeutical Properties of Bioactive Compounds Extracted from Ganoderma lucidum Species on Acute and Chronic Diseases
Authors: Pascale Carolina , Sirbu Rodica , Cadar Emin
Published: May 2023

Ganoderma lucidum or Reishi is a medicinal mushroom of significant importance that is being used for the prevention and treatment of various diseases, due to its numerous pharmacological and therapeutic properties. The Ganodermataceae family is diverse, but the focus is on the lucidum species because of its specific biologically active macromolecules such as polysaccharides, triterpenoids, steroids, phenolic compounds, lactones, and fatty acids that were isolated from the mycelia and fruiting bodies. Ganoderma lucidum species have many benefits over the immune system (promoting health) and properties such as: anti-tumoral, anti-inflammatory, anti-allergic, anti-viral, anti-bacterial and antioxidant. Based on the literature, triterpenoids and polysaccharides are the most abundant active compounds that possess anti-diabetic, hepatoprotective, cytotoxic and anti-hypertensive effects. A review of the literature showed that there are very few papers that studied semisolid dosage forms preparations based of Ganoderma lucidum extract to have been used on damaged skin and skin diseases, neither have there been enough studies on its anti-aging properties.
The Significant Role Played by Long Social Connections and a Pleasant Interactive Experience Among Traditional Bapedi Music Practitioners
Authors: Lebaka Morakeng Edward Kenneth
Published: May 2023

In Greater Sekhukhune District Municipality, Limpopo Province in South Africa, music is a form of communication and plays a functional role in the Bapedi society. Indigenous Bapedi music is often collaborative and requires communal undertaking and coordinated cooperation. Music and dancing are social activities in which almost traditional Bapedi music practitioners participate. Rhythm and percussive sounds are highly emphasized in indigenous Bapedi music, while the melodies and rhythms of the music usually form the song texts. The main objective of this paper is to examine the creative domain of musical performance among different traditional Bapedi music practitioners, and to share some insight on how traditional Bapedi music practitioners organize, conceptualize, and experience various aspects of their daily lives. The main question the study addressed is: what motivates traditional Bapedi music practitioners to work together, and to struggle for common goals? To achieve the objectives of this study, contextual approach was employed, and data was collected through observations, interviews and video recordings of rehearsals and performances during social gatherings. Relevant sources to the context of this study in the form of published journal articles, book chapters, books and theses were also consulted to compare and complement data collected from the field research. Closer investigation has revealed that music is not alien or extraneous to the Bapedi people, but part of the Bapedi culture. It was concluded that in Bapedi society, traditional music groups were also formed voluntarily with the primary purpose of music performance and dancing, by invitation at ceremonial occasions.
Morphological and Molecular Characterization of Diplogasteroides sp., a Cryptic Population of the Haslacheri Group (Diplogastridae), and Parasitorhabditis terebranus (Rhabditidae) from Korea
Authors: Mwamula Abraham Okki , Lee Sang Myeong , Jung Young Hak , Lee Ho-wook , Kim Yi Seul , Kim Young Ho , Lee Dong Woon
Published: May 2023

Diplogasteroides sp., a cryptic population of D. haslacheri, and Parasitorhabditis terebranus were reported from the frass of Monochamus alternatus galleries in dead Pinus thunbergii for the first time in Korea. Females and males are morphologically characterized and their linked DNA barcodes (18S-rRNA, 28S-rRNA, ITS-rRNA and COI) supplied. Females and males of the two species from Korea conform to the original species descriptions from Europe and the USA, with variations in a few details in morphometrics. Specifically, Diplogasteroides sp. is morphologically very similar to D. haslacheri. However, it cannot be designated as D. haslacheri due to the existence of cryptic species complex within the haslacheri group (D. haslacheri, D. asiaticus, D. nix, D. andrassyi, and D. carinthiacus), a condition requiring hybridization studies to test species identity within the group. Based on analysis of COI sequences, differences among these cryptic species are evident. Thus, in addition to hybridization tests, the COI might be a powerful DNA barcoding marker for the precise identification of these cryptic species within the genus. Additionally, this is the first molecular characterization of P. terebranus, and the species is herein recorded for the first time outside its type locality.
Prevalence of the bla
CTX-M and bla
TEM genes among extended-spectrum beta lactamase–producing Escherichia coli isolated from broiler chickens in Indonesia
Authors: Faridah Hayyun Durrotul , Wibisono Freshindy Marissa , Wibisono Freshinta Jellia , Nisa Nabilatun , Fatimah Fatimah , Effendi Mustofa Helmi , Ugbo Emmanuel Nnabuike , Khairullah Aswin Rafif , Kurniawan Shendy Canadya , Silaen Otto Sahat Martua
Published: May 2023

Introduction

Infections of humans and animals by multidrug resistant bacteria are increasing because of the inappropriate use of antibiotics. Disease management may be more challenging if Escherichia coli produce extended-spectrum beta-lactamase (ESBL), which could cause resistance to aztreonam and third-generation cephalosporins. This study was aimed at determining the prevalence of the bla
CTX-M and bla
TEM genes among ESBL-producing E. coli isolated from broiler chickens in Indonesia.

Material and Methods

A total of 115 broiler cloacal swab samples were obtained from 22 farms and studied for the presence of E. coli. The isolates were identified using approved standard methods and were purified on eosin methylene blue agar media. The E. coli isolates were subjected to sensitivity testing using beta-lactam antibiotics, and ESBL production was confirmed by a double-disc synergy test. The presence of the bla
CTX-M and bla
TEM genes was identified using a PCR.

Results

It was found that 99/115 (86.1%) of the isolated E. coli were resistant to beta-lactam antibiotics and 34/115 (29.6%) of them were phenotypically detected to be ESBL producers. Of the 34 isolates that were confirmed ESBL producers, 32/34 (94.1%) of them harboured the bla
CTX-M and 13/34 (38.2%) the bla
TEM genes. The bla
CTX-M and bla
TEM genes were detected together in 12/34 (35.3%) isolates.

Conclusion

This study discovered that broiler chickens are possible reservoirs of ESBL-producing E. coli that may infect humans. Thus, a committed public health education campaign is recommended in order to mitigate the potential threat to human health.
Further Evidence of an Association Between a Positive Child Behavior Checklist-Bipolar Profile and a Diagnosis of Pediatric Bipolar Disorder: A Meta-Analysis
Authors: DiSalvo Maura , Vater Chloe Hutt , Green Allison , Woodworth K. Yvonne , Farrell Abigail , Biederman Joseph , Faraone Stephen
Published: May 2023

Background

Previous research has found that a unique profile of the Child Behavior Checklist comprising of aggregate elevations of the Attention, Anxiety/Depression and Aggression scales (A-A-A profile, CBCL-Bipolar (BP) profile, CBCL-Dysregulation profile (DP); henceforth CBCL-BP/DP profile) is associated with a clinical diagnosis of pediatric bipolar (BP) disorder.

Objective

The main aim of the study is to evaluate the strength of the association between the CBCL-BP/DP profile and the clinical diagnosis of pediatric BP disorder through a meta-analysis.

Methods

A literature search was performed to identify studies that examined the association between a positive CBCL-BP/DP profile and a clinical diagnosis of pediatric BP disorder. The meta-analyses first examined studies assessing the rates of a positive CBCL-BP/DP profile in youth with BP disorder versus those with 1) ADHD, anxiety/depression, or disruptive behavior disorders (DBDs), and 2) non-bipolar controls. The second analysis evaluated studies examining the rates of pediatric BP disorder in youth with and without a positive CBCL-BP/DP profile.

Results

Eighteen articles met our inclusion and exclusion criteria, and fifteen articles had adequate data for meta-analysis. Results showed that BP youth were at significantly increased odds of having a positive CBCL-BP/DP profile compared to those with other psychiatric disorders (i.e., ADHD, anxiety/depression, or DBDs) (pooled OR=4.34, 95% CI=2.82, 8.27; p<0.001) and healthy control groups (pooled OR=34.77, 95% CI=2.87, 420.95; p=0.005). Further, meta-analysis results showed that youth with a positive CBCL-BP/DP profile were at significantly increased odds of having a BP disorder diagnosis compared to those without (pooled OR=4.25, 95% CI=2.12, 8.52; p<0.001).

Conclusion

Our systematic review and meta-analysis of the extant literature provides strong support for the association between the CBCL-BP/DP profile and pediatric BP disorder.
Identifikasi Elemen dan Pola Ruang pada Taman Vihara Dharma Giri di Kecamatan Pupuan, Kabupaten Tabanan, Bali
Authors: Tantowi Benny , Sugianthara Anak Agung Gede , Dharmadiatmika I Made Agus
Published: May 2023

Identification of Elements and Spatial Patterns in the Dharma Giri Monastery Park in Pupuan District, Tabanan Regency, Bali. This research is motivated by the absence of a description of the spatial pattern used and the character of the forming elements at Vihara Dharma Giri in Pupuan District, Tabanan Regency, Bali. This study aims to identify the physical conditions, elements and patterns of space and the philosophical concept of the Vihara Dharma Giri Garden. The method used in this research is a survey method with data collection techniques by means of observation, interviews, and literature study as well as descrictive qualitative data analysis. The results of data analysis are presented in the form of an illustration of the Dharma Giri Vihara space pattern. Based on the analysis, it is found that the characters are based on the Vihara Dharma Giri by the biophysical aspects and have a spatial pattern that follows the Tri Hita Karana concept. In the division of space, there is also a garden area which is also called a statue garden. The role and elements of society are needed in maintaining and caring for the Vihara Dharma Giri so that its sustainability is maintained.

 

Keywords: Dharma Giri Monastery, Identification, Landscape-forming Elements, Spatial Patterns
Perencanaan Jalur Interpretasi Wisata Sejarah di Desa Blahbatuh, Kabupaten Gianyar, Bali
Authors: Yulianto Albirahman , Kohdrata Naniek , Sukewijaya I Made
Published: May 2023

Planning of historical tourism interpretation route in Blahbatuh Village, Gianyar Regency, Bali. Blahbatuh village is one of the villages in Blahbatuh district, Gianyar regency, Bali, with historical heritage in the form of historical stories and sites. Blahbatuh village starts to develop tourism programs that involves historic sites. One of tourism program that can be developed in Blahbatuh is a historical tourism that utilizing interpretation activity. This study has two objectives, that are to identify the potential historical sites as an attraction for tourist, and to plan interpretation route for historical tourism in Blahbatuh. This study uses survey method with planning stage from Gold which consist of preparation, inventory, analysis, synthesis, and planning. Descriptive analysis is applied in biophysics, and tourism aspects which consists of attraction, amenities, accessibility, and ancillary. Quantitative analysis is applied to measure the variable of tourist attraction. The result is formulated into an interpretation route plan, that is based on themes, space programming plan, and circulation plan. The interpretation route of Blahbatuh Village’s historical heritage is developed from the era of Bali ancient kingdom, to the colonial time within the village vicinity of Blahbatuh.
Desain Lanskap Taman Dipangga sebagai Taman Sejarah dan Rekreasi berbasis COVID-19
Authors: Hetharia Bartholomew Jordan , Franjaya Eduwin Eko
Published: May 2023

Landscape Design of Taman Dipangga as a Historical and Recreational Park based on COVID-19. Taman Dipangga is a city park with a strategic location and easy access. In the middle of the COVID-19 pandemic crisis, city parks, which are part of open public spaces, should be resilient and adaptive to the current situation. Taman Dipangga, likewise, must adapt to the current situation in terms of design and amenities. As one of the cultural and historical attractions in Bandar Lampung, Taman Dipangga has the potential to become one of the favorite tourist destinations for visitors. This research aims to design Taman Dipangga by highlighting the historical aspects as well as the recreational components that are responsive to COVID-19. This qualitative research was conducted using the survey method, which included observation, interview, and literature review that refers to the design process. This research leads to the use of historical and recreational concepts in Taman Dipangga to optimize the potential of Taman Dipangga by representing it through the Krakatau Monument, the form of design, the division of space and its naming, as well as the selection of vegetation based on the condition of the location on Mount Krakatau and the surrounding area. Taman Dipangga will be more than just a recreation park; it will also be a place for education and a cultural heritage site.
Optimalisasi Destinasi Pariwisata dengan Pemberdayaan Potensi Alam Pesisir Pantai Utara sebagai Daya Tarik Kota Tegal: Analisis Swot
Authors: Wiyanti Sari
Published: May 2023

Kota Tegal yang berada di pesisir pantai utara mempunyai beberapa wisata pantai yaitu Pantai Alam Indah, Pantai Pulau Kodok, Pantai Batam sari dan Pantai Muarareja. Kota Tegal memiliki daya tarik tersendiri dibandingkan daerah sekitarnya, sehingga Pemerintah da­­e­rah dan pemangku kepentingan lainnya dalam upaya optimalisasi destinasi pariwisata p­a­n­­­tainya, dibutuhkan strategi manajemen yaitu dengan strategi analisis SWOT. Penelitian ini merupakan penelitian deskriptif yang bersifat kualitatif dari studi kasus. Pengumpulan data di­lakukan melalui survey dan observasi lapangan. Obyek penelitian ini adalah 4 des­ti­na­si pariwisata pantai. Pengambilan sampel dalam penelitian ini dilakukan dengan Purposive sa­m­pling. Hasil penelitian ini adalah keunggulan kota Tegal memiliki 4 destinasi wisata pa­n­tai dengan udara yang bersih, biaya murah dan aksesnya mudah dijangkau. Untuk me­wu­jud­kan destinasi pariwisata pantai sebagai daya tarik kota Tegal bukanlah hal yang mudah. Sa­ra­­na dan prasarana, fasilitas lainnya yang kurang baik. Tidak ada promosi gencar yang dilakukan pihak pengelola dalam memperkenalkan destinasi pariwisata ini. Permasalahan pe­­­­­­ngelolaan destinasi antara pemeritah daerah dan pengelola/masyarakat sebagai peng­ham­bat masuknya investor untuk berpartisipasi dalam mengembangkan destinasi pariwisata, dan akan memperlambat pembangunan pariwisata pantai ini. Ancaman bagi bisnis pariwisata pan­tai kota Tegal adalah wilayah disekitarnya memiliki destinasi pariwisata yang sama de­ngan fasilitas lebih baik.
Usulan Perbaikan Kualitas Produk Shuttlecock “Claudia” Dengan Metode Six sigma di Perusahaan Shuttlecock “Claudia” Kabupaten Tegal
Authors: Sulistyani Tri , Sari Mitra
Published: May 2023

Penelitian ini bertujuan untuk mengetahui faktor-faktor penyebab terjadinya produk cacat shuttlecock merk “Claudia”, untuk mengetahui bagaimana penggunaan metode six sigma dalam per­baikan kualitas produk shuttlecock merk “Claudia”, dan memberikan usulan perbaikan kua­li­tas produk shuttlecock “Claudia” untuk meningkatkan kualitasnya dan me­ngu­rangi poduk cacat. Tek­nik pengumpulan data yang digunakan dalam penelitian adalah ob­ser­vasi dan wawancara. Se­dangkan teknik analisis data yang digunakan adalah metode six sig­ma. Kesimpulan dari pe­ne­li­tian ini adalah 1) Implementasi six sigma dalam penelitian ini me­­nggunakan siklus DMAIC (De­fine Measure Analyze Improve Control), 2) Jenis produk ca­cat shuttlecock “Claudia” paling tinggi adalah Batang Bulu Rusak (BBR), Penjahitan Antar Bulu Lepas (PABL), dan Ke­se­im­ba­ng­an laju Shuttlecock Goyah (KLSG) dengan persentase kerusakan/cacat dari total jumlah pro­duk­si sebesar 4,31%, 3) Kualitas produk shuttlecock “Claudia” memiliki nilai sigma 3,69, jadi po­sisinya ada pada kategori rata-rata industri. Pe­ru­sa­haan diharapkan dapat meningkatkan nilai sig­manya dengan melakukan berbagai upaya per­­baikan, 4) Usulan perbaikan kualitas produk shu­ttlecock “Claudia” diklasifikasikan ber­da­sar­kan 4 faktor penyebab, yaitu manusia, metode, me­sin, dan material, kemudian masing-ma­si­ng faktor penyebab diberikan rekomendasi atau usu­lan tindakan perbaikan untuk dapat me­ni­ngkatkan kualitas produk shuttlecocknya, 5) Tahap ter­ak­hir dalam usulan perbaikan kua­li­tas produk shuttlecock “Claudia” adalah control (pe­nga­wa­san), usulan perbaikan yang dapat di­berikan adalah perusahaan harus lebih ketat dalam mela­ku­kan pengawasan baik bahan ba­ku, metode, mesin, ataupun karyawannya dalam bekerja, ke­mu­di­an semua produk cacat harus ada catatan setiap harinya dan terdokumentasi dengan baik jenis ca­cat­nya, jumlah cacatnya, me­sin yang menyebabkan cacat, tahapan proses menyebabkan cacat, dsb.. Pencacatan ini bisa di­bantu dengan menggunakan lembar pengecekan.
Pengaruh Green Marketing terhadap Citra Merek Perusahaan Ades dengan Kualitas Produk Sebagai Moderasi
Authors: Harly Kelvin , Kusuma Linda
Published: May 2023

Abstrak

Perusahaan perlu mengamati penggunaan metode green marketing sebagai salah satu cara dalam membangun citra merek, serta penting untuk memperhatikan kualitas produk perusahaan. Green marketing dan kualitas produk merupakan aspek penting bagi mahasiswa dalam melakukan penilaian terhadap citra merek. Tujuan dalam penelitian ini ialah ingin mengetahui pengaruh green marketing terdapat citra merek, serta kualitas produk sebagai moderasi. Sampel dalam penelitian ini sebanyak 100 mahasiswa UKSW dengan menggunakan purposive sampling sebagai pemilihan sampel. Penelitian ini menunjukan bahwa green marketing berpengaruh terhadap citra merek, serta kualitas produk mempeharuhi kedua hubungan variabel tersebut.

Kata kunci: Citra Merek, Kualitas Produk, Green Marketing.

Abstract

Companies need to observe green marketing methods as a way to build a brand image, because it is important to observing the quality of the company's products. Green marketing and product quality are important aspects for students in assessing brand image. This study aimed to determine the impact of green marketing to brand image, and product quality as a moderation of green marketing and product quality. This research indicate that green marketing  has a positive effect on brand image and product quality is proven to moderate both variable relationships.

Keywords: Brand Image, Product Quality, Green Marketing.
Pengaruh Kinerja Lingkungan dan Pengungkapan Lingkungan Terhadap Kinerja Ekonomi dengan Ukuran Perusahaan Sebagai Variabel Moderasi
Authors: Sari Novita , Asrori Asrori
Published: May 2023

Sari

Tujuan penelitian ini yaitu untuk menguji pengaruh kinerja lingkungan dan pengungkapan lingkungan terhadap kinerja ekonomi dengan ukuran perusahaan Sebagai variabel moderasi. Populasi penelitian ini adalah perusahaan pertambangan, industri dasar dan kimia, dan industri barang konsumsi yang terdaftar di Bursa Efek Indonesia tahun 2017-2019. Sampel dipilih menggunakan kriteria tertentu (purposive sampling) dan dihasilkan 16 perusahaan sampel dengan 48 unit analisis. Teknik analisis data menggunakan analisis statistik deskriptif dan statistik inferensial dengan metode moderated regression analysis. Hasil penelitian membuktikan secara empiris bahwa kinerja lingkungan dan pengungkapan lingkungan tidak berpengaruh terhadap kinerja ekonomi. Selain itu, ukuran perusahaan mampu memoderasi dan memperkuat hubungan antara pengaruh kinerja lingkungan dan pengungkapan lingkungan terhadap kinerja ekonomi. Simpulan dari hasil penelitian ini adalah tinggi rendahnya kinerja ekonomi suatu perusahaan tidak dipengaruhi oleh kinerja lingkungan dan pengungkapan lingkungan yang dilakukan oleh perusahaan. Keterbatasan penelitian ini adalah tahun penelitian kurang terkini, dan penelitian hanya menggunakan dua variabel independen. Oleh karena itu, saran untuk peneliti selanjutnya untuk menambah variabel lain yang dapat memberikan pengaruh terhadap kinerja ekonomi.

Kata Kunci: Kinerja Lingkungan, Pengungkapan Lingkungan, Ukuran perusahaan, Kinerja ekonomi

 

Abstract

The purpose of this study is to examine the effect of environmental performance and environmental disclosure on economic performance with firm size as a moderating variable. The population of this study is mining companies, basic and chemical industries, and consumer goods industries listed in Indonesia Stock Exchange in 2017-2019. The sample was selected using certain criteria (purposive sampling) and resulted in 16 sample companies with 48 units of analysis. The data analysis technique used descriptive statistical analysis and inferential statistics with the method of moderated regression analysis. The results of the research prove empirically that environmental performance and environmental disclosure have no effect on economic performance. In addition, firm size is able to moderate and strengthen the relationship between the effect of environmental performance and environmental disclosure on economic performance. The conclusion from the results of this study is that the high and low economic performance of a company is not influenced by environmental performance and environmental disclosures made by the company. The limitations of this study are that the year of the study was less recent, and the study only used two independent variables. Therefore, Suggestions for further researchers to add other variables that can have an influence on economic performance.

Keywords: Environmental Performance, Environmental Disclosure, Firm Size, Economic Performance
Faktor-faktor yang Mempengaruhi Profitabilitas Bank Umum Syariah di Indonesia Periode 2016-2020
Authors: Sumule Natalia , Wirman
Published: May 2023

Knowing the factors that affect profitability, which is represented by ROA at Islamic Commercial Banks (BUS) in Indonesia, is the goal of this research. The independent va­ri­a­bles used include the ratio of NPF, FDR, and BOPO while the dependent variable used is ROA. Multiple linear reg­ression analysis method is the analytical method used in this study. The results of hypothesis testing show that NPF and FDR have no significant effect on ROA, in contrast to BOPO which shows a significant negative effect on ROA. Ho­wever, simultaneously NPF, FDR, and BOPO have a sig­ni­ficant effect on ROA. The final conclusion in this study, the factor that affects the profitability of BUS is only one variable, namely BOPO. This means that the higher the BOPO value, the decrease in profitability will be more pro­no­unced so that banks are advised to control banking ope­ra­ti­onal costs and on the other hand be able to increase banking operating income
Pengaruh dari Brand Image, Perceived Quality, dan Brand Awareness Terhadap Customer Satisfaction dan Brand Loyalty Starbucks
Authors: Valensia Angelina , Candy
Published: May 2023

Penelitian bertujuan untuk menginvestigasi seberapa besar loyalitas dari sebuah merek yang dipengaruhi oleh brand image, perceived quality dan brand awareness. Objek penelitian yang diambil adalah salah satu merek internasional yang cukup terkenal di Indonesia yaitu Starbucks. Penelitian kali ini akan membahas mengenai seberapa besar kesetiaan konsumen terhadap Starbucks yang sudah terdengar tidak asing lagi dan banyak sudah mengenali merek tersebut dimana menjual minuman kopi dengan harga yang lumayan tinggi dibandingkan kopi lain dikarenakan kekuatan dari brand. Banyak sekali peminat dari Starbucks bahkan para wisatawan asing cenderung membeli merek tersebut di negara mana pun dikarenakan Starbucks sudah terkenal mendunia. Brand loyalty adalah salah satu preferensi yang mempengaruhi konsumen untuk membeli suatu produk secara berulang terus menerus. Lokasi penelitian dilaksanakan di Starbucks yang berada di Kota Batam. Metode pengambilan sampel diambil tidak secara acak sebanyak 191 responden. Hasil yang ditemukan bahwa adanya hubungan signifikan antara brand image, perceived quality dan brand awareness terhadap brand loyalty. Sedangkan perceived quality dan brand awareness berhasil dimediasikan oleh customer satisfaction.
Analisis Sektor Unggulan Komparatif dan Kompetitif di Kabupaten Cilacap
Authors: Raharjo Teguh Hardi , Ismiyati  , Jaenudin Ahmad
Published: May 2023

Kabupaten Cilacap merupakan wilayah yang memberikan kontribusi terbesar kedua setelah Kota Semarang terhadap Pendapat Domestik Regional Bruto (PDRB) Provinsi Jawa Tengah. Namun, dalam kurun waktu 11 tahun terakhir, kon­tri­bu­si PDRB Kabupaten Cilacap tersebut cenderung mengalami penurunan. Kondisi tersebut disebabkan laju pertumbuhan PDRB Kabupaten Cilacap yang juga cenderung mengalami penurunan. Penelitian ini bertujuan untuk menganalisis sektor per­ekonomian di Kabupaten Cilacap yang memiliki keunggulan secara komparatif dan kompetitif. Diharapkan dengan dike­ta­hui­nya sektor tersebut, Pemerintah Daerah setempat dapat memaksimalkan sektor unggulan tersebut dalam rencana pem­ba­ngunan ekonomi daerah, sehingga pertumbuhan ekonomi di Kabupaten Cilacap dapat meningkat secara berkelanjutan. Metode analisis data yang digunakan dalam penelitian ini meng­gunakan analisa Location Quotient untuk mengetahui sektor yang unggul secara komparatif dan Shift Share untuk mengetahui sektor yang unggul secara kompetitif. Penelitian ini menggunakan jenis data sekunder berupa data PDRB Provinsi Jawa Tengah dan Kabupaten Cilacap Tahun 2011 – 2021 yang dipublikasikan secara resmi di situs Badan Pusat Statistik (BPS). Hasil penelitian menunjukkan bahwa pertambangan dan penggalian merupakan sektor yang memiliki keunggulan secara komparatif, sedangkan sektor yang memiliki keunggulan kompetitif adalah pengadaan listrik dan gas, informasi dan komunikasi, jasa perusahaan, serta jasa kesehatan dan kegiatan sosial.
La administración electrónica al servicio  de las políticas públicas
Authors: García Martín José Aurelio
Published: May 2023

El presente trabajo analiza desde diversas perspectivas la importancia creciente de la administración electrónica en la configuración y ejecución de las políticas públicas. Se analizan en primer término las dificultades de considerar la administración electrónica en su dimensión exclusivamente instrumental, dado que la misma modifica cuestiones sustanciales de los métodos tradicionales de relacionarse con los ciudadanos y de ejecutar las políticas públicas, por lo que no deben desaprovecharse las posibilidades que ofrece para reconfigurar las políticas tradicionales, a veces de forma esencial. El trabajo centra la atención en determinadas políticas públicas horizontales en las que esta capacidad de modificación e impulso es más evidente, como son la política de calidad de la gestión pública; las políticas de desarrollo democrático y en particular el desarrollo del “gobierno abierto”; las políticas de inclusión y la política económica. Para finalizar, el artículo considera la política autónomo de uso efectivo de la administración electrónica, dada la brecha existente entre la oferta y la demanda de servicios electrónicos y la inclinación cultural de los ciudadanos por la administración tradicional, cuestión que ha sido sistematizada y analizada en diversos informes internacionales.
A CONEXÃO ENTRE O MILITARISMO, O ESTADO MODERNO E AS CONSTITUIÇÕES
Authors: Afonso José Roberto Rodrigues , Santiago Silas
Published: May 2023

Este trabalho trata do papel da militarização na formação do Estado Moderno. Procura demonstrar como a estruturação dos exércitos nacionais importou para a construção dos conceitos de nacionalismo, de cidadania e de pertencimento do cidadão com relação a seu país. Trata-se de uma revisão de literatura, utilizando pesquisa bibliográfica e eletrônica. Tomou-se como base teórica autores como Thornhill (2021) e Cotta (2007). Como resultados, salienta-se que o serviço militar obrigatório, ou conscrição, foi elemento importante na formação dos modernos estados nacionais. Em contrapartida, ressalta-se as constrições dos direitos civis ocasionados pela mesma militarização. Tal contradição desemboca na situação vivida por alguns países, de fortalecimento excessivo da militarização nas áreas civis. Com o esgotamento dos modelos de evolução constitucional, debate-se quis seriam os motores para o futuro. Conclui-se que esses novos modelos devem ser compatíveis com a evolução democrática que conseguimos alcançar.
آلية صنع السياسات العامة في أقليم كردستان
Authors: حمود ا.م.د محمد علي , سلمان أسراء حاتم
Published: May 2023

(الحكومة الأتحادية ، الحكومات المحلية) ، في مقاطعة العاصمة ، في مقاطعة العاصمة ، 2003 ، بعد هذه العروض حكومة محلية مسؤولة عن صنع وتنفيذ قرارات عامة في المحافظات الثلاث (اربيل ، دهوك ، السليمانية).

   والجدير بالذكر أن الحكومة تعاني من مشاكل كبيرة في الخارج منذ عام 2003 ، وقد واجهتك مشاكل كبيرة في المشاكل الخاصة بالمشروع.
The Double-Edged Sword Effect of Social Media on COVID-19 in Sub-Saharan Africa
Authors: Rukasha Ivy
Published: May 2023

The COVID-19 pandemic has entered its third year ravaging the lives of people worldwide. During the pandemic, social media usage has increased significantly, as people seek not only for educative information about COVID-19 but also for platforms to collectively respond to the outbreak. An increase in traffic to websites and government sources has significantly contributed to an overall increase in internet usage during the pandemic. On a positive note, social media is being used by the scientific community as an ally to enhance research coordination and quickly disseminate crucial information about COVID-19 across geographical boundaries and time zones. However, a major problem with social media has been the spread of “infodemic” or widespread misinformation about treatment and vaccines for the virus. The COVID-19 “infodemic” led to an increase in vaccine hesitancy, panic, fear and confusion in people and it is amplifying rumours and questionable information. Consequently, the objective of this review is to look at the role of social media as a tool for the good, the bad and the ugly in the ongoing fight against COVID-19.
Social Media, the changing Newsroom and Electoral Politics in Zimbabwe
Authors: Choto Isaac , Ncube Bengani
Published: May 2023

The rise of social media in Zimbabwe has instigated changes in journalism practice, politics and political communication. This paper examines the nexus between social media, journalism practice and politics in Zimbabwe, focusing on the 2018 general elections. The study is informed by the realisation that past studies on how social media interacts with society have tended to focus on a single dimension. Such single dimensions have included social media and newsroom changes, social media and journalism ethics, together with social media and political communication (Mabweazara 2014). No study, however, has attempted to show the connections between all these dimensions, which is a gap that is observable in social media studies. Using interviews with mainstream journalists in Zimbabwe and content analysis of political social media posts, the study shows that newsroom changes are tied to changes in political communication. The results also show that newsroom changes in Zimbabwe cannot be disconnected from political dynamics because journalism practice itself, even before the rise of social media, is shaped and structured by political dynamics so much that contrary to Marxian theorisation, in Zimbabwe, it is the political-consciousness base that determines the economic and other facets of the superstructure.