bluuebunny/crossref_metadata_2025 huggingface dataset:
Social Vulnerability Score: a Scalable Index for Representing Social Vulnerability in Virtual Community Resilience Testbeds
Authors: Enderami S. Amin , Sutley Elaina J.
Published: November 2022

Incorporating social systems and phenomena into virtual community resilience testbeds is uncommon but becoming increasingly important. Social vulnerability indices are a convenient way to account for differential experiences and starting conditions of the population in resilience assessments. This paper proposes a scalable index, termed Social Vulnerability Score (SVS), to serve the purpose of testbed development. The SVS overcomes two important limitations of existing indices: it is constructed using an approach that does not decrease in validity with changing spatial resolution, and it only needs to be calculated for the geographic area of interest, instead of for the entire county thereby significantly reducing computational effort for testbed developers and users. The proposed SVS aggregates the ratio of a set of demographics from U.S. Census datasets at the desired location against their national average values. The resulting scores are mapped into five levels, called zones, ranging from very low vulnerability (zone 1) to very high (zone 5). The validity of the SVS was investigated through a regression analysis of flood outcomes in Lumberton, North Carolina caused by Hurricane Matthew in 2016. The resulting correlations between the SVS zones and post-disaster outcomes of household dislocation and home repair times match the social vulnerability theory. The paper concludes with a comparison between the SVS and two existing social vulnerability indices at the census tract level for the State of Kansas.
Work-Related Stress, Quality of Life, and Coping Mechanism Among Lecturers in a Tertiary Educational Institution in Anambra State, Nigeria
Authors: Chukwuemeka Uchechukwu Martha , Okonkwo Uchenna Prosper , Njoku Chibuike Jefferen , Igwe Emeka Sylvester , Oyewumi Taiwo Joseph , Ugwuanyi Daniel Chimmuanya
Published: November 2022

Work-related stress (WRS) is a highly prevalent and pervasive
problem that can result in loss of productivity and deterioration
of lecturer’s health. Lecturing work requires coping with some of
the stressful situations found in any workplace. The study
determined the work-related stress, coping mechanisms, and quality
of life among lecturers at Nnamdi Azikiwe University
(NAU).

Method:This was a cross-sectional survey
involving 283 lecturers consecutively recruited from NAU. The
Health and Safety Executive Work Related stress (HSE-WRS),
Work-Related Quality of life (WRQL), and Brief-cope Questionnaires
(BCQ) were applied to assess the participant's work-related stress,
quality of work life, and coping mechanism(CM) respectively. Data
were analyzed using Spearman rank and Mann-Whitney U tests at a
0.05 level of significance.

Result: Age, years of practice, and academic
rank had no statistically significant relationship with
work-related stress with p-values given as: p=0.96, p =0.9, and
0.21 respectively. Age and gender were significantly related to the
coping mechanism with p-values: p=0.00 and p= 0.01 respectively.
The quality of life of lecturers was significantly associated with
age with p-values of 0.03. The years of practice have no
statistically significant association with coping
mechanisms.

Conclusions: there was a statistically
significant relationship between age and active coping; there was a
statistically significant relationship between gender and
work-related stress; there was no statistically significant
relationship between years of experience and QOWL; the QOWL of
lecturers had a statistically significant correlation with their
age, and gender affected the coping mechanism of lecturers at NAU.
Also, this study revealed that male lecturers coped better with the
rigorous demands of the job in contrast to female lecturers
First terbinafine-resistant Trichophyton indotineae isolates with Phe397Leu and/or Thr414His mutations in Turkey: Differences in response to resveratrol treatment
Authors: Durdu Murat , Kandemir Hazal , Karakoyun Ayşe Sultan , Ilkit Macit , Tang Chao , de Hoog Sybren
Published: November 2022

The increase in terbinafine-resistant superficial dermatophytosis has become a major problem over the last decade. In this report, we present two cases of infection with terbinafine-resistantTrichophyton indotineae, a species diagnosed for the first time in Turkey. One of the patients harbored aCD36mutation. Both strains harbored the same amino acid substitution in the squalene epoxidase (SQLE) gene, whereas one of the isolates had another as yet unknown mutation. Clinical improvement was observed with resveratrol treatment in the patient with theCD36mutation, but this compound was not effective in the other patient.
The curcumin analogue PAC has potent anti-anaplastic thyroid cancer effects
Authors: Al-Mohanna Mai , Alhabardi Samiah A. , Alraouji Noura N. , Almohanna Falah , Al-Otaibi Baseem , Al-Jammaz Ibrahim , Aboussekhra Abdelilah
Published: November 2022

Anaplastic thyroid carcinoma (ATC) is the rarest type of thyroid cancer but is the common cause of death from these tumors. The aggressive behavior of ATC makes it resistant to the conventional therapeutic approaches. Thus, the present study was designed to evaluate the anti-ATC efficacy of the curcumin analogue PAC. We have shown that PAC induces apoptosis in thyroid cancer cells in a time-dependent fashion through the mitochondrial pathway. Immunoblotting analysis revealed that PAC suppressed the epithelial-to-mesenchymal transition (EMT) process in ATC cells by increasing the epithelial marker E-cadherin and reducing the level of the mesenchymal markers N-cadherin, Snail, Slug and Twist1. This anti-EMT effect was confirmed by showing PAC-dependent inhibition of the proliferation and migration abilities of ATC cells. In addition, PAC downregulated ALDH1 and suppressed the formation of thyroid tumorespheres in vitro. Interestingly, PAC inhibited the AKT/mTOR pathway in ATC cells. Indeed, PAC downregulated mTOR and its downstream effectors p70S6K and 4E-BP1 more efficiently than the well-known mTOR inhibitor rapamycin. In addition to the promising in vitro anticancer efficacy, PAC significantly suppressed the growth of humanized thyroid tumor xenografts in mice. Together, these findings indicate that PAC could be considered as promising therapeutic agent for anaplastic thyroid carcinomas.
Evaluation of irrigation water quality under newly weathered soil in hot and semi-humid region of central India
Authors: Lal Bharat , Shukla Abhishek Kumar , Kumar Pavan , Singh Shusheel Kumar , Singh Yogeshwer , Chaturvedi Sushil Kumar
Published: November 2022

Throughout the pre-monsoon, monsoon, and post-monsoon seasons, the participants in this research took water samples that were later examined for a variety of physiochemical characteristics. Irrigation water quality metrics such as SAR, RSC, Na%, KR, MHR, PS, PI, and RSBC were used in conjunction with the calculation of IWQI in order to conduct an evaluation of the appropriateness of the irrigation water. The major dominated anions in the study area were found HCO3−> SO42−> Cl− during all the season, while cation was fluctuated from Na+> Mg2+> Ca2+> K+ at pre-monsoon season and Na+> Ca2+> Mg2+> K+ at both monsoon and post-monsoon season. Ca (Mg)- HCO3−, Na- HCO3−and mixed type water was found in the study area which was originated from the silicate weathering and evaporate dissolution. Some samples were reported with high KR, MHR, Na%, RSC, PS and RSBC which exceeding limit and unsuitable for irrigation use. Out of the total collected water samples 32%, 64%, 8%, 44%, 12%in pre-monsoon and 24%, 60%, 8% 16%, 12% in post-monsoon period were not suitable for irrigation purpose with having high KR, MHR, Na%, RSC and PS, respectively. While, 8% (KR), 52% (MHR), 12%(RSC) and 8% (PS) was also unsuitable for irrigation purpose during monsoon period. However, the IWQI of the study area was noted 48% water sample having above the limit > 100 which was unsuitable for irrigation water.
Theoretical, Numerical and Experimental Research on Vibration Suppression and Energy Collection of Vehicle Active Suspension Based on Time-Delay Control
Authors: Wu Kaiwei , Atay Fatihcan M , Ren Chuanbo
Published: November 2022

This paper, the impact of time-delay feedback control on vibration energy collection and damping performance is discussed. A time-delay control system of active suspension based on a 1/4 vehicle nonlinear model is designed. The linear motor is used as the actuator of active suspension. The variable learning factor particle swarm optimization algorithm is used to optimize the optimal control parameters of active suspension with time delay. The characteristic root clustering method is proposed to analyze the stability of the active suspension control system with time delay. Finally, the energy recovery and vibration reduction of passive suspension, active suspension without time-delay, and active suspension with time-delay are simulated. The simulation results show that the energy-feeding efficiency of the active suspension with time-delay control under harmonic and random excitation is 114.54% and 20.09% higher than that of the active suspension without time-delay control. Finally, a test bench is built to verify the correctness of the simulation results. The experimental and simulation results error is within 15%, which meets the engineering requirements. The proposed method can significantly improve the energy collection capacity.
Quantification of mitochondrial cfDNA reveals new perspectives for early diagnosis of colorectal cancer
Authors: Linke Christian , Hunger Richard , Reinwald Mark , Deckert Markus , Mantke René
Published: November 2022

Background: To unravel how the integrity of nuclear and mitochondrial circulating cell-free DNA (cfDNA) contributes to its plasma quantity in colorectal cancer (CRC) patients.
Methods: CfDNA from plasma samples of 80 CRC patients stratified by tumour stage and 50 healthy individuals were extracted. Total cfDNA concentration was determined and equal template concentrations (ETC) were analyzed by quantitative real-time PCR (qPCR) resulting in small and long fragments of KRAS, Alu and MTCO3. The obtained data was also examined relative to the total cfDNA concentration (NTC) and diagnostic accuracy was estimated using receiver operating characteristics.
Results: Total cfDNA levels were significantly higher in CRC group compared to healthy control and increased with tumour stage. Long nuclear fragment levels were significantly lower in CRC patients in ETC but not NTC condition. The integrity indices of nuclear cfDNA decreased from controls to patients with highly malignant tumor. Mitochondrial cfDNA fragment quantities were strongly reduced in early and late stages of tumor patients and prognostic value was higher in ETC. Predictive models based on either ETC or NTC predictor set showed comparable classification performance.
Conclusion: Increased blood cfDNA concentration in late UICC stages inversely correlate with nuclear cfDNA integrity index and suggest that necrotic degradation is not a major cause for higher total cfDNA quantity. The diagnostic and prognostic value of MTCO3 is highly significant in early stages of CRC and can be evaluated more comprehensively, using ETC for qPCR analysis.
Trial Registration: The study was registered retrospectively on DRKS, the german register for clinical trials (DRKS00030257, 29/09/2022).
The changing pattern of common respiratory viruses among children from 2018-2021 in Wuhan, China
Authors: Wan Lu , Li Liangyu , Zhang Haiyue , Liu Chan , Li Ruiyun , Wu Xiaojun , Chen Jianjun
Published: November 2022

Background
Acute respiratory infections in children are a global public health challenge. Owing to the coronavirus disease (COVID-19) pandemic, non-pharmaceutical interventions, including patient isolation, social distancing, handwashing, and mask wearing, have been widely implemented, impacting the transmission of common respiratory viruses. We aimed to clarify the epidemiological features of respiratory viruses in children aged under 14 years in Wuhan before and after COVID-19.
Methods
Respiratory specimens were collected from patients aged < 14 years at two hospitals in Wuhan, China, from January 2018 to December 2021. Seven respiratory viruses were identified using immunofluorescence. Pathogen profiles and seasonality were analysed.
Results
The number of visits and virus detection rate decreased dramatically after February 2020. The respiratory virus detection rate peaked in January and December and decreased dramatically in February and August. The detection rate was lower in 2021 than in 2018 and 2019. Respiratory syncytial virus (RSV) was identified as the leading pathogen in children aged < 1 year and 1–4 years before and after the COVID-19 pandemic. In children aged 5–14 years, influenza virus was detected with the highest rate before, and RSV after, the COVID-19 pandemic. RSV was the most common coinfection virus.
Conclusions
This study revealed the epidemiological patterns of common respiratory viruses from 2018 to 2021. The spectrum of pathogens involved in paediatric respiratory infection partly changed. Non-pharmaceutical interventions offered fewer opportunities for spread of common viruses, also induced an “immunity debt” and could have negative consequences when the pandemic is under control in Wuhan.
EGFR-regulated EMT is a driver of vasculogenic mimicry in Nasopharyngeal Carcinoma
Authors: Yuan# Yue , Luo# Yunfan , Feng# Huiru , Deng Rui , Liang Bijun , Huang Haoran , Yuan Xiaofei , Chen Zilu , Yu Bolong , Liu Xiong , Peng Xiaohong
Published: November 2022

Background
Vascular mimicry is emerging as a potential target for anti-tumorigenesis.It involves the formation of microvascular channels composed of tumor cells. However, the mechanism of how tumor cells build into microvascular channels is not clear.The existence of a relationship between EMT and VM has been reported in the literature but the exact regulatory mechanism is unclear. Whether EMT regulates VM formation and its specific mechanism need to be further verified in NPC
Materials and Methods
We detected the relationship between EMT indicators and VM by immunohistochemical experiments. Also, the relationship between EMT indexes and VM indexes and clinical staging was analyzed. Cellular assays and immunoprotein blotting assays were used to detect EMT and VM changes in cells after addition of EGFR inhibitors. VM and EMT indices were examined after EGFR-targeted drug treatment in a subcutaneous tumorigenesis assay in nude mice.
Conclusion
EGFR-regulated EMT is a driver of vasculogenic mimicry in Nasopharyngeal Carcinoma.
Distinct Roles of Two Types of Lipid Droplets inside the Nucleus in Liver Diseases
Authors: Imai Norihiro , Ohsaki Yuki , Cheng Jinglei , Zhang Jingjing , Mizuno Fumitaka , Tanaka Taku , Yokoyama Shinya , Yamamoto Kenta , Ito Takanori , Ishizu Yoji , Honda Takashi , Ishigami Masatoshi , Wake Hiroaki , Kawashima Hiroki
Published: November 2022

Aim
Lipid droplets have been found in the nuclei of hepatocytes, however, their role in liver is not clearly understood. The purpose of this study was to explore the pathophysiological roles of intranuclear lipid droplets in liver diseases.
Method
This study included 80 patients who underwent liver biopsies. A part of the liver biopsy specimen was dissected and fixed for electron microscopic observation. Lipid droplets in the nuclei were distinguished into two types based on the presence of adjacent cytoplasmic invagination of the nuclear membrane: nuclear lipid droplet (nLD) and cytoplasmic lipid droplet invagination with nucleoplasmic reticulum (cLD in NR).
Results
nLDs were found in 69% of the liver biopsy samples, and cLDs in NR were found in 32%. A significant positive correlation was observed between the frequencies of nLD and cLD in NR. Although nLD was frequently found in hepatocytes of patients with nonalcoholic steatohepatitis, there was no correlation between the frequency of nLD and hepatic steatosis, indicating that nLD does not directly reflect cytoplasmic lipid accumulation. Significant positive correlations were found between the frequencies of nLD and endoplasmic reticulum (ER) expansion or liver enzymes, suggesting that nLD is formed in the nucleus under ER stress. Conversely, cLD in NR showed a significant negative correlation with hepatic steatosis, implying that cLD in NR is formed in lipid-restricted hepatocytes. Moreover, no correlations were observed between the frequency of cLD in NR and ER expansion.
Conclusion
This study revealed two distinct pathophysiological roles of lipid droplets in liver diseases.
Long-term Prognosis of Levator Aponeurosis Plication for Aponeurotic Ptosis Caused by Conjunctivitis: A Case Report
Authors: Li Chen , Zhao Yanyong
Published: November 2022

Purpose: To report a rare clinical case of a patient suffered from unilateral aponeurotic ptosis caused by conjunctivitis and evaluate the long-term prognosis of levator aponeurosis plication technique.
Methods: Levator aponeurosis plicationtechnique with local anesthesia was preformed to treat the patient and made a moderate overcorrection of the patient's ill eye. Follow up for 4 months to record patient’s recovery.
Results: During the operation, we saw there were little orbital septal fat left and lots of strip fibrous adhesions between orbital septum and the levator aponeurosis. Postoperative follow-up showed a good recovery with approximately the same degree of opening in both eyes and no complications such as incomplete closure.
Conclusion: Conjunctivitis will cause massive inflammatory cellular infiltration and fibrin exudation which may even spread to the surface of the levator aponeurosis. When there is no barrier of orbital septal fat, the fibrin will fibrate into tenacious adhesions, form scar-like tissue that causes the dysfunction of the levator aponeurosis, eventually results in ptosis. The release of the adhesions followed by levator aponeurosisplication procedure can completely improve the ptosis symptoms.
Views on patient portal use for adolescents in mental health care - a qualitative study
Authors: Nielsen Martine Stecher , Steinsbekk Aslak , Nøst Torunn Hatlen
Published: November 2022

Background
Digitalization of health care has opened up for new ways to involve and engage patients. With this, increased attention has been put on digital patient portals. There exists some research on patient portals for adolescent patients in general and for adults in mental health care. However, no studies on patient portals for adolescents in mental health care have been identified in a recent review. The aim was therefore to explore the views on using patient portals for adolescents in mental health care among persons involved in and/or being affected by the introduction of a patient portal.
Methods
A qualitative study was conducted using individual semi-structured interviews with 14 persons who were healthcare providers in child and adolescent mental health care, young representatives from the user panel, or persons affiliated with an EHR-project introducing a patient portal. The main questions addressed their views on introducing patient portals for adolescents in mental health care and how patient portals and access to clinical notes can affect them and their treatment.
Results
The findings were categorised into four main themes; “Does access to a patient portal help or harm adolescents?”, “Who decides access?”, “Mostly a political goal” and “Need for support and competency”. Informants mentioned situations in which both adolescents’ and parents’ access to a patient portal could help adolescents in mental health care, but also where it could potentially harm their treatment and threaten confidentiality. Most informants thought that healthcare providers should have the autonomy to determine which information should be shared with whom, but also requested guidelines to ensure equal practice and support in difficult situations. Some perceived patient portals as the result of a political decision, rather than healthcare providers´ wishes, while others described it as a necessary development towards democratization.
Conclusion
The informants’ views varied from thinking that a patient portal could support adolescents in mental health care, to worrying that it could be detrimental to the treatment. Informants emphasized that the management should facilitate training and support for healthcare providers in using patient portals and telehealth.
COVID-19 patients in the COVID-19 Recovery and Engagement (CORE) Clinics in the Bronx
Authors: Darrell Megan , Eligulashvili Anna , Miller Carolyn , Lee Jeylin , Congdon Seth , Lee Jimmy S , Hsu Kevin , Yee Judy , Islam Marjan , Duong Tim Q.
Published: November 2022

BACKGROUND: Early in the pandemic, we established COVID-19 Recovery and Engagement (CORE) Clinics in the Bronx and implemented a detailed evaluation protocol was implemented to assess physical, emotional, and cognitive function, pulmonary function tests, and imaging for COVID-19 survivors. Here we report our findings five months post-acute COIVD-19.
METHODS: Main outcomes and measures included pulmonary function tests, imaging tests, and a battery of symptom, physical, emotional, and cognitive assessments 5 months post-acute COVID-19.
FINDINGS: Dyspnea, fatigue, decreased exercise tolerance, brain fog, and shortness of breath were the most common symptoms but there were generally no significant differences between hospitalized and non-hospitalized cohorts (p>0.05). Many patients had abnormal physical, emotional, and cognitive scores, but most functioned independently; there were no significant differences between hospitalized and non-hospitalized cohorts (p>0.05). Six-minute walk test, lung ultrasound, and diaphragm excursion were abnormal but only in the hospitalized cohort. Pulmonary function tests showed moderately restrictive pulmonary function only in the hospitalized cohort but no obstructive pulmonary function. Newly detected major neurological events, microvascular disease, atrophy, and white-matter changes were rare, but lung opacity and fibrosis-like findings were common after acute COVID-19.
INTERPRETATION: Many COVID-19 survivors experienced moderately restrictive pulmonary function, and significant symptoms across the physical, emotional, and cognitive health domains. Newly detected brain imaging abnormalities were rare, but lung imaging abnormalities were common. This study provides insights into post-acute sequelae following SARS-CoV-2 infection in neurological and pulmonary systems which may be used to support at-risk patients, develop effective screening methods and interventions.
Estimation of IRNSS-retrieved integrated precipitable water over a few locations in India
Authors: Jaiswal Rajasri Sen , K Thirumala Lakshmi
Published: November 2022

We estimated integrated precipitable water (IPWV) over a few locations in India, namely Bhubaneswar, Gadanki, Goa, Kanakapura, and Kolkata, from the tropospheric slant delay (TSD) obtained from the Indian Regional Navigation Satellite System (IRNSS). We attempted to find the factors that control the IPWV. We show that the total solar irradiance (TSI) controls IPWV beyond doubt. The latter is best explained as a function of surface temperature (ST), surface pressure (SP), relative humidity (RH), and TSI. We present the functional relations between these meteorological elements and IPWV. Besides, we discuss the evolution of IPWV with the advance of northeast and southwest monsoon. The locations on the East Coast show characteristics of meteorological elements different from locations on the West Coast of India. The dynamicity of the mutual relations between these elements depends on the season and geography of a location. IRNSS-retrieved IPWV along the zenith over a location shows a good agreement with radiosonde-retrieved IPWV.
Adaptive finite-time fault-tolerant control for quadrotor trajectory tracking systems under a novel smooth event-triggered mechanism
Authors: Zhu Wenxing , Wang Lihui
Published: November 2022

This article proposes an adaptive finite-time fault-tolerant control scheme based on a smooth event-triggered mechanism for quadrotor trajectory tracking systems subject to actuator faults and external disturbances. The novel finite-time performance function guarantees the tracking errors are convergent within a prescribed time. The smooth event-triggered mechanism is proposed to overcome the discontinuous triggered signals and decrease transmission resource consumption. Meanwhile, the Zone behavior can be excluded by the positive sampling intervals. Then, the radial basis function (RBF) neural networks are utilized to deal with the model uncertainty, and the adaptive laws are designed to estimate the unknown actuator failures effectively. Finally, an adaptive controller based on the novel time-varying barrier Lyapunov function (BLF) is proposed, and rigorous theoretical analyses are conducted to demonstrate that the tracking errors are convergent within the finite time. Simulation experiments verify the effectiveness of the proposed control scheme.
Total hip arthroplasty with transverse subtrochanteric osteotomy and monocortical locking plate for the treatment of Crowe Ⅳ developmental dysplasia of the hip
Authors: Xu wenting , Gu Guoqing , Zheng Guoqing , Lu Chunde , Ni Cheng
Published: November 2022

Background
To explore the technique and the clinical results of total hip arthroplasty ( THA ) with transverse subtrochanteric osteotomy and monocortical locking plate for Crowe type Ⅳ developmental dysplasia of the hip ( DDH ).
Methods
From April 2015 to April 2019, 21 patients ( 23 hips ) with Crowe Ⅳ DDH were treated by the technique of THA with transverse subtrochanteric osteotomy and monocortical locking plate. Postoperative clinical and radiological results were evaluated.
Results
All of the patients were followed up for the average of 33 months. All patients had no osteotomy nonunion, infection, prosthesis loosening and vascular nerve injury. 1 patient experienced dislocation one week after the operation because of bad posture. Harris score changed from 35.6 points ( 25–51 ) before surgery to 88.1 points ( 76–96 ) after surgery.
Conclusions
THA with transverse subtrochanteric osteotomy and monocortical locking plate internal fixation for the patients with Crowe type Ⅳ DDH is an effective way.
Sharing of Best Practices from an Emergency Medical Team Deployment in Papua New Guinea: Piloting a Health Promotion Program Targeting COVID-19 Vaccine Uptake
Authors: Maddah Diana , Vadi Ramnath , Marmont Lizzi , Hallit Souheil , Mohammad Mariam
Published: November 2022

Background
COVID-19 tremendously affected Papua New Guinea in late 2021, which accompanied by a low vaccination rate (< 4%), lead to an International Emergency Medical Team (EMT) Request for Assistance. The study's aim was to assess the knowledge, skills and attitude of health-care workers (HCWs) before and after a workshop conducted by the UK EMT in developing best practices related to Risk Communication and Community Engagement (RCCE) integration within a COVID-19 emergency response.
Methods
A participatory workshop was piloted in Western Highland Province among 71 HCWs. Training of trainers’ approach was adopted to build the capacity of health workers in advocating for vaccines uptake. A perception survey was used at the baseline and at the end of the workshop to assess the knowledge, skills, and attitude of the participants towards COVID-19 vaccine acceptance.
Results
The healthcare professionals were not well equipped with accurate, scientific, and up-to-date information related to COVID-19 vaccines, which led to concern and fear among them. HCWs reported being a source of information for community members about COVID-19 vaccines. The paired t-test showed a significant increase in the knowledge, skills, and attitude of the participants toward COVID-19 vaccines after the workshop. Participants described being ready to engage community influencers and cascade training to further reach out to community groups
Discussion
Integrating RCCE within EMT deployments plays a crucial role in leveraging healthcare capabilities to influence community members and advocate for COVID-19 vaccines uptake; which will ultimately decrease morbidity and mortality.
Food Inventory Demand Forecasting Tool
Authors: B Kavya , R Deetchika , V Radhamani , D Manju
Published: November 2022

In today’s modern world, people are busy and food is mandatory for them to live. Food service providers help people by offering them good food. But they face a problem with inventory forecasting. Food inventory demand forecasting is a key component to food service providers. Food companies are more concerned with products having a short shelf-life and seasonal changes. The demand may depend on many hidden contexts and seasonal changes which remains to be non-trivial. In this paper we present an ensemble learning approach that employs dynamic integration of regressor for better handling of fluctuations in consumer demands. Demand forecasting is the process in which historical data is used to estimate the quantity of food item customer will purchase based on location, cuisine etc., It can be nearly impossible to have the required number of raw materials on hand for the preparation of food at any given time without proper demand forecasting processes. A food delivery service must deal with a lot of raw materials which are likely to decay, so it is important for such a company to accurately forecast daily and weekly demand. More inventory in the warehouse means more risk of wastage, and not enough inventory leads to out-of-stocks and push customers to seek solutions from the competitors. This decision tool is developed using Streamlit where the demands needed by the customers is forecasted using ensemble method named Random Forest in Machine Learning models, evaluated by Root Mean Squared Logarithmic Error (RMSLE) and visualized the forecasted data using Power BI.
Star-Polymer Unimolecular Micelles for Brain Specific Delivery of Anticancer Drug
Authors: Malhotra Mehak , Pardasani Meenakshi , Srika Priyadharshini , Abraham Nixon , jayakannan Manickam
Published: November 2022

Nanocarrier mediated therapeutic delivery to brain tissue remains an impediment by tightly controlled transportation across the blood brain barrier (BBB). Here, we report a well-defined core-shell star-shaped unimolecular micelle (star-UMM) based on biodegradable polycaprolactone platform as an efficient BBB breaching nanovector for brain specific administration of anticancer drug doxorubicin (DOX) andin vivobioimaging via near-infrared biomarker IR780. The star-UMM was engineered by controlling the polymer topology of hydrophobic and hydrophilic segments from interior to exterior.In vivoimaging in mice was directly evident of prolonged blood circulation of star-UMM for more than 72 h, and the whole-organ image-quantification further substantiated its efficient BBB breaching ability. Star UMM having 15% of DOX exhibited excellent stability in blood circulation, reduction in cardiotoxicity, substantial uptake in the cortical neurons of mouse brain, lysosomal enzymatic-biodegradation, and negligible immunogenicity or necrosis; hence, proving the impact of the star UMM in brain-specific drug delivery.
Optimizing piezoelectric vibration-based energy harvester using numerical-analytical method and soft computing algorithms
Authors: Babaei Alireza , Parker Johne , Moshaver Paria
Published: November 2022

Tuning and optimizing of piezoelectric vibration-based energy harvesters (PVEH) is essential to render sufficient amount of energy. As a modification to the tuning mass and dynamic magnifier of conventional PVEH, a novel integrated multisystem of cantilever-oscillator-spring is proposed in which the vibratory analysis discloses significant mutation in resonance frequency depending on the oscillator mass and spring constant values, showing hyper-tuning capability. Obtaining the maximum extractable amount of electric voltage is the ultimate goal which is an optimization problem with oscillator mass and spring stiffness as design parameters. The extended Hamilton’s principle along with the Galerkin modal decomposition techniques are adopted to find analytical-numerical response of the system undergoing harmonic base excitations. To optimize the voltage frequency response function (FRF), global evolutionary optimization algorithm is adopted. The closed-form voltage function is a hard-to-evaluate and computationally-expensive function. To overcome such issues, soft computing techniques is adopted. Using adaptive neuro fuzzy logic (ANFIS), a regressor model is designed to execute function evaluations in the genetic optimization procedure. Fuzzy inference system (FIS) is developed using 64 fuzzy ules derived from Gaussian and Gaussian-Bell shaped membership functions (MFs). Such a regressor model is utilized in the genetic algorithm launching with 200 iterations and 50 populations. It is observed that using roulette wheel, tournament, and random selection methods; rs= 100, rm= 2 are found as the optimal design parameter values. To validate the correctness of the implemented soft computing algorithm; the optimal voltage FRF is obtained using the closed-form analytical-numerical solution and compared with random case studies. It is shown that the nominated optimal values render the most obtainable amount of voltage. Eventually, it is inferable that the spring-mass subsystem integration with the cantilever energy harvester, drastically improves the amount of harnessed voltage. Furthermore, optimization of such integrated multi-system via soft computing techniques results in the maximum amount of harvestable voltage.
Determination of benzoylurea insecticides in juice and water samples by high performance liquid chromatography after dispersive solid phase extraction with MOF based sorbent
Authors: Feng Zhi , Liu Li , Hadrai Ahmed , Motlak Mahmoud
Published: November 2022

In this study, an effective graphene oxide-metal organic framework (GO-MOF(801)) sorbent was employed for the detection of benzoylurea insecticides (BUs) in aqueous solution using high performance liquid chromatography (HPLC). The optimal extraction parameters for the suggested dispersive solid phase extraction (DSPE) include sorbent dose = 20 mg, elution solvent = dichloromethane, solution pH = below 7.0 and sonication time = 3 min. The linear dynamic ranges and detection limits for BUs samples under above extraction conditions were ranged from 0.5–250 µg L− 1 and 0.1–1.11 µg L− 1, respectively. Moreover, the proposed DSPE/HPLC assay was employed for the monitoring of insecticides in river water and grape juice samples. The obtained recoveries of the targets were between 94.0 and 106.0% and relative standard deviation (RSD) values were less than 7.5%. The application of the GO-MOF(801) as a sorbent in DSPE of insecticides analytes showed to be reliable and sensible methodology for BUs monitoring in different real samples.
Seasonal variations of river and lake water surface areas at global scale
Authors: Carbonneau Patrice , Bizzi Simone
Published: November 2022

Much progress has been made over the last decade to build global inventories of freshwater resources. However, existing freshwater inventories are generally produced for a fixed period in time and/or do not discriminate lakes from rivers. The emergence of deep learning methods and Big Data platforms such as Google Earth Engine offers a potential solution. Here we present a unique raster dataset at 10 m spatial resolution which classifies freshwater into rivers and lakes for a study site covering 89% of the terrestrial landmass and for the months of April, July and October 2021. This data gives us the first global-scale direct count of lakes larger than 1 hectare as ~7.3 million. We also present the first intra-annual ranges for the areas distinctly occupied by rivers and lakes where we find that basins influenced by the Asian summer monsoon (e.g. the Ganges) closely followed by the Amazon display the largest intra-annual range of river area per unit basin area. Finally, we find that whilst maximum of lake water surface occurs in October 2021, the maximum river surface is in July 2021 leading us to conclude that the global maximum occurrences of river water and lake water are not synchronous.
Identification of key genes and Construction of miRNA-mRNA regulatory network in Psoriasis based on Bioinformatics Analysis
Authors: Chen Lu , Wang Xiaochen , Liu Chang , Qiu Wenhong , Guo Kaiwen
Published: November 2022

Background
Psoriasis is a chronic inflammatory skin disease with a long course of disease and a tendency to relapse, and the pathogenesis is not completely clear. This article aims to identify the key differentially expressed genes and miRNAs of PS, construct the core miRNA-mRNA regulatory network, and to explore its underlying molecular mechanism through integrated bioinformatics approaches.
Methods
Two gene expression profile datasets (GSE166388 and GSE153007), and two microRNA (miRNA) expression profile datasets (GSE115293 and GSE145305) were downloaded from the Gene Expression Omnibus (GEO) database and analyzed by GEO2R. Intersection differentially expressed genes (DEGs) and intersection differentially expressed miRNAs (DEMs) were screened, respectively. Metascape database was used to enrich the analysis of intersection DEGs and to explore their functions. Target genes of differentially expressed miRNAs were predicted by the online database miRNet. The protein–protein interaction files of intersection target genes were obtained by String, and the miRNA-mRNA network was constructed by Cytoscape software. In addition, the CIBERSORT online web tool was used to analyze the immune infiltration of the dataset GSE166388, and the relative abundance of 22 immune cells in the disease and normal control tissues was calculated and evaluated.
Results
A total of 660 intersection DEGs (397 upregulated mRNAs and 263 downregulated mRNAs) and 9 intersection DEMs (5 upregulated miRNAs and 4 downregulated miRNAs) were screened. 340 intersection dysregulated genes from 660 intersection DEGs and 7232 miRNA target genes were identified. The miRNA-mRNA regulatory network was constructed and the Top10 elements were obtained by CytoHubba, including hsa-miR-155-5p, hsa-miR-497-5p, hsa-miR-132-3p, hsa-miR-125b-5p, CDK1, CCNA2, CCNB1, STAT1, BUB1, and NCAPG.
Conclusion
In this study, the miRNA-mRNA core regulatory pairs formed by hsa-miR-155-5p, hsa-miR-497-5p, hsa-miR-132-3p, hsa-miR-125b-5p, CDK1, CCNA2, CCNB1, STAT1, BUB1, and NCAPG may be involved in PS in the progress. This study provides new insights for the discovery of new potential targets and further study of the molecular mechanism of PS.
Decision-Making Preferences in a Palliative Setting in Jordan
Authors: Shamieh Omar , Alarjeh Ghadeer , Qadire Mohammad , Nasser Mahmoud Abu , Abu-Farsakh Fadi , Al-Hawamdeh Abdulrahman , Alomari Mohammad , Amin Zaid , Alrjoob Waleed , Ayad Omar , Taba’a Amal Al , Hui David , Bruera Eduard , Yennu Sriram
Published: November 2022

Purpose
Understanding patients' decision-making preferences is crucial to enhancing patients’ outcomes. The current study aims to identify Jordanian advanced cancer patients’ preferred decision-making and to explore the associated variables of the passive decisional making preference.
Methods
We used a prospective cross-sectional survey design. Patients with advanced cancer referred to the palliative care clinic at a tertiary cancer center were recruited. We measured patients’ decision-making preferences using the Control Preference Scale. Patients’ satisfaction with decision-making was assessed with the Satisfaction with Decision Scale.
Results
A total of 200 patients completed the survey. Patients' median age was 49.8 years, 57.5% were female. Of them, 81 (40.5%) preferred passive decisional control, 35% (n=70) and 24.5% (n=49) preferred shared and active decision control respectively. Less educated females were found to have a statistically significant association with passive decisional control preferences. Around 84% (n = 168) of participants were satisfied with the way the decisions were made, 82% (n = 164) of patients were satisfied with the actual decisions made, and 71.5 % (n = 143) were satisfied with the shared information. The agreement level between decisional-making preferences and actual decisional practices was significant (ⱪ coefficient = 0.69; 95% CI = 0.59 to 0.79).
Conclusion
The study's results demonstrate that a passive decision control preference was prominent among patients with advanced cancer in Jordan. Further studies are needed to evaluate decision control preference for additional variables throughout the cancer illness trajectory to inform policies and improve practice.
Time series analysis and prediction of scarlet fever incidence trends in Jiangsu Province, China: using ARIMA and TBATS models
Authors: Guo zaijin , Gong hao , Li Yunshui , Tao chenyue , Zhou LuoJing
Published: November 2022

Objective: Scarlet fever is an increasingly serious public health problem that has attracted widespread attention worldwide. In this study, two models were constructed based on time series to predict the number of scarlet fever incidence in Jiangsu province, China
Methods: Two models, ARIMA model and TBATS model, were constructed to predict the number of scarlet fever incidence in Jiangsu province, China, in the first half of 2022 based on the number of scarlet fever incidence from 2013-2021, and root mean square error (RMSE) and mean absolute percentage error (MAPE) were used to select the models and evaluate the performance of the models.
Results: The incidence of scarlet fever in Jiangsu province from 2013 to 2021 was significantly bi-seasonal and trendy, and the best ARIMA model established was ARIMA(1,0,1)(2,1,1)12, with RMSE=92.23 and MAPE=47.48% for the fitting part and RMSE=138.31 and MAPE=79.11 for the prediction part. The best The best TBATS model is TBATS(0.278,{0,0}, -, {<12,5>}) with RMSE=69.85 and MAPE=27.44% for the fitted part. The RMSE of the prediction part=57.11, MAPE=39.52%. The error of TBATS is smaller than that of ARIMA model for both fitting and forecasting.
Conclusion: The TBATS model outperformed the most commonly used SARIMA model in predicting the number of scarlet fever incidence in Jiangsu Province, China, and can be used as a flexible and useful tool in the decision-making process of scarlet fever prevention and control in Jiangsu Province
LCBDE, three ports, and primary continuous suture of common bile duct for the treatment of cholelithiasis and choledocholithiasis: a retrospective study
Authors: Zhao Chunlong , Hu Weidong , Ge Chen , He Songbing , Zhao Wanwen , Zhang Zhengwei , Dai Zhengxing , Tang Neng , Zhang Shuo , Wang Weiguo , Gu Jiayu , Xu Zipeng , Chen Chaobo
Published: November 2022

Background
Laparoscopic cholecystectomy (LC) plus laparoscopic common bile duct exploration (LCBDE) is convenient in the treatment of cholelithiasis in combination with choledocholithiasis. It has the advantage of accelerated recovery. This retrospective study aimed to summarize the experience of cholelithiasis and choledocholithiasis treatment via LC plus LCBDE approach in Eastern China.
Methods
Patients diagnosed with cholelithiasis and choledocholithiasis between July 2019 and October 2021 at the Xishan People’s Hospital of Wuxi City were included in the study. During treatment, patients who received LC+LCBDE+primary suturing of the CBD were assigned to the LCBDE-P group, and those who received LC+LCBDE+T-tube drainage of CBD were assigned to the LCBDE-T group. The measurement data were compared between the two groups. P-values < 0.05 indicated statistical significance.
Results
A total number of 88 patients (48 females and 40 males) were divided into two groups: LCBDE-P (n=50) and LCBDE-T (n=38). Multiple linear regression analysis showed that LCBDE-P affected the risk-adjusted hospitalization stay (unstandardized coefficient, -5.352 days; 95% CI: -0.387 to -4.761; P < 0.001) and medical cost (unstandardized coefficient, -0.494 RMB; 95% CI: -0.712 to -0.277; P < 0.001) with significant differences. On the other hand, no significant differences were detected in the operation time, intraoperative hemorrhage, clearance rate of CBD stones, postoperative liver function, and postoperative complications (P > 0.05) between the two groups.
Conclusions
LCBDE is a safe and feasible strategy for the management of cholelithiasis and choledocholithiasis. Compared to LCBDE-T, LCBDE-P decreases hospital stays and medical costs during hospitalization.
Citizen Science Data Reveals Environmental Influence on Sightings of Great White Sharks in Mossel Bay, South Africa
Authors: Maycock Sophie , Rodenburg Frans , Ladley Mike , Klimley A. Peter , Tudorache Christian
Published: November 2022

Whilst previous studies have described the impact of various environmental conditions on behaviour and abundance of great white sharks (GWS), existing knowledge gaps must be addressed in order to turn the tide on their population declines. This study used data collected by a diving tour operator, to investigate how environmental and anthropogenic variables affected the rate of GWS sightings. Observation data were collected by trained crew and volunteers alongside tourists, and combined with externally sourced environmental data. Hurdle modelling identified that the probability of sighting at least one GWS fluctuated seasonally (peaking during winter), but was also correlated with minimum running air temperature, water visibility and the length of time the boat stayed at anchor. The rate GWSs were sighted also rose in winter, and was associated with maximum running air temperature, the arrival time, seal activity, and the wind direction and speed. These findings indicate that environmental conditions directly impacted upon the sighting frequency, but also influenced habitat selection on a fine spatial scale. This study emphasises that collaboration with ecotourism companies could represent a valuable, inexpensive alternative for scientific data collection, as long as powerful statistical methods are used, the influence of human activity is considered and results are interpreted with consideration of the data collection methodology.
Tin(II) and Lead(II) Compounds Supported by Bulky b-Diketiminate Ligands: Synthesis, Structural Characterization and Computational Studies
Authors: Gurubasavaraj Prabhuodeyara M , Jiménez-Pérez Víctor M. , Muñoz-Flores Blanca M.
Published: November 2022

In this paper, we report two structurally characterized, tin(II) and lead(II) compounds supported by sterically encumbered β-diketiminate ligands and are synthesized from the reaction of the bulky diketiminate lithium salt [HC(R)CNAr]2Li (1 Ar = 2,6-iPr2C6H3; R = tBu, 2 Ar = 2,4,6-Me3C6H2; R = Me) with MCl2 (M = Sn, Pb) affords 3 [HC(Me)CN(2,6-iPr2C6H3)]2SnCl and 4 [HC(Me)CN(2,4,6-Me3C6H2)]2PbCl. In the solid state, the structures indicate that the β-diketiminate backbone is essentially planar, and the metal centers reside in distorted tetrahedral environments with one vertex occupied by a lone pair of electrons. The bond angles at the metal center are in the range 82.5(5)-92.76(5)°, and the most acute angle is associated with the bite of the chelating ligand. Both compounds were characterized by elemental analysis, NMR, EI-MS, and single-crystal X-ray. We have investigated the influence of this lone pair on the geometries of the metal halide complexes 3 and 4, the isostructural tin and germanium complexes (3 and 5 respectively) using DFT calculations. B3LYP/LANDL2DZdp calculations show the lone pair in the lead complexes is significantly more diffuse than in the tin and germanium analogues and only a small amount of hybridization between the 6s and 6p orbitals is observed.