bluuebunny/crossref_metadata_2025 huggingface dataset:
Intelligence and neuroticism in relation to depression and psychological distress: Evidence from two large population cohorts
Authors: Navrady L.B. , Ritchie S.J. , Chan S.W.Y. , Kerr D.M. , Adams M.J. , Hawkins E.H. , Porteous D. , Deary I.J. , Gale C.R. , Batty G.D. , McIntosh A.M.
Published: January 2017

Background:

Neuroticism is a risk factor for selected mental and physical illnesses and is inversely associated with intelligence. Intelligence appears to interact with neuroticism and mitigate its detrimental effects on physical health and mortality. However, the inter-relationships of neuroticism and intelligence for major depressive disorder (MDD) and psychological distress has not been well examined.

Methods:

Associations and interactions between neuroticism and general intelligence (g) on MDD, self-reported depression, and psychological distress were examined in two population-based cohorts: Generation Scotland: Scottish Family Health Study (GS:SFHS, n = 19,200) and UK Biobank (n = 90,529). The Eysenck Personality Scale Short Form-Revised measured neuroticism and g was extracted from multiple cognitive ability tests in each cohort. Family structure was adjusted for in GS:SFHS.

Results:

Neuroticism was strongly associated with increased risk for depression and higher psychological distress in both samples. Although intelligence conferred no consistent independent effects on depression, it did increase the risk for depression across samples once neuroticism was adjusted for. Results suggest that higher intelligence may ameliorate the association between neuroticism and self-reported depression although no significant interaction was found for clinical MDD. Intelligence was inversely associated with psychological distress across cohorts. A small interaction was found across samples such that lower psychological distress associates with higher intelligence and lower neuroticism, although effect sizes were small.

Conclusions:

From two large cohort studies, our findings suggest intelligence acts a protective factor in mitigating the effects of neuroticism on psychological distress. Intelligence does not confer protection against diagnosis of depression in those high in neuroticism.
Social Policy Expansion in Latin America
Authors: Garay Candelaria
Published: January 2017

Throughout the twentieth century, much of the population in Latin America lacked access to social protection. Since the 1990s, however, social policy for millions of outsiders - rural, informal, and unemployed workers and dependents - has been expanded dramatically. Social Policy Expansion in Latin America shows that the critical factors driving expansion are electoral competition for the vote of outsiders and social mobilization for policy change. The balance of partisan power and the involvement of social movements in policy design explain cross-national variation in policy models, in terms of benefit levels, coverage, and civil society participation in implementation. The book draws on in-depth case studies of policy making in Argentina, Brazil, Chile, and Mexico over several administrations and across three policy areas: health care, pensions, and income support. Secondary case studies illustrate how the theory applies to other developing countries.
Motivation in War
Authors: Berkovich Ilya
Published: January 2017

This book fundamentally revises our notion of why soldiers of the eighteenth century enlisted, served and fought. In contrast to traditional views of the brutal conditions supposedly prevailing in old-regime armies, Ilya Berkovich reveals that soldiers did not regard military discipline as illegitimate or unnecessarily cruel, nor did they perceive themselves as submissive military automatons. Instead he shows how these men embraced a unique corporate identity based on military professionalism, forceful masculinity and hostility toward civilians. These values fostered the notion of individual and collective soldierly honour which helped to create the bonding effect which contributed toward greater combat cohesion. Utilising research on military psychology and combat theory, and employing the letters, diaries and memoirs of around 250 private soldiers and non-commissioned officers from over a dozen different European armies, Motivation in War transforms our understanding of life of the common soldier in early modern Europe.
Occupational/Career Amotivation and Indecision for Gifted and Talented Adolescents: A Cognitive Decision-Making Process Perspective
Authors: Jung Jae Yup
Published: January 2017

Two alternative versions of a model of the cognitive decision-making processes of gifted and talented adolescents associated with occupational or career indecision were tested in this study. A psychometrically rigorous survey instrument was used to collect data from 664 adolescents attending three academically selective high schools in Sydney, Australia. Data were analysed using structural equation modelling procedures. The superior model suggested that idiocentric orientations toward the future and social influences from the family are likely to direct gifted and talented adolescents away from a state of occupational amotivation, which is a likely predictor of occupational indecision. The findings may be used to more clearly understand and to better assist gifted and talented adolescents experiencing difficulty with their occupational decisions.
LAW, RELIGION, AND HUMAN RIGHTS: SKEPTICAL RESPONSES IN THE EARLY TWENTY-FIRST CENTURY
Authors: Little David
Published: January 2017

Disputes over the nature, basis, and enforceability of human rights go back to early 1947, when the drafting of the Universal Declaration of Human Rights (UDHR) first began. Nor were the disputes limited to the drafting process. Intense arguments emerged among social scientists, philosophers, religious leaders, legal thinkers, and public figures around the world over the very idea of human rights, namely, the notion that human beings possess legally enforceable entitlements to certain protections and opportunities simply because of their common humanity.
Authoritarian leadership and employee silence in China
Authors: Duan Jinyun , Bao Chanzi , Huang Caiyun , Brinsfield Chad Thomas
Published: January 2017

We examine the relationship between authoritarian leadership and employee silence behaviour with 324 employees in 16 state-owned manufacturing enterprises in China. We draw from theories of motivation and person–environment fit to explain the mediating roles of psychological safety and organization-based self-esteem, and the moderating effects of power distance orientation. Regression analyses show that authoritarian leadership has a positive relationship with employee silence behaviour. Mediation analyses show that both psychological safety and organization-based self-esteem partially mediate the relationship between authoritarian leadership and employee silence. Moderation analysis revealed that the direct relationship between authoritarian leadership and employee silence behaviour is stronger for employees with high (as opposed to low) power distance orientation. Additionally, moderated-mediation analyses show that the mediating effects of both psychological safety and organization-based self-esteem are stronger for employees with low (as opposed to high) power distance orientation. Implications for theory and practice are discussed.
Proportion of Time Spent Delivering Support Predicts Stop Smoking Advisor Quit Rate Independently of Training, Experience, and Education
Authors: Anastasi Natasha , Lusher Joanne , Chandler Chris
Published: January 2017

Despite a downwards trend in smoking prevalence, smoking remains the UK's biggest preventable cause of premature mortality. Specialist stop smoking support programmes provided by the NHS have helped to reduce smoking prevalence and whilst there has been a vast amount of research investigating the most effective behavioural and pharmacological support models, little is known about the impact of smoking cessation advisor's smoking status and clinical effectiveness on quit rates. This study aimed to identify factors that contribute to NHS stop smoking advisor performance using a quantitative cross-sectional design via an online survey that was completed by 159 participants in 24 London boroughs. Multiple regression analyses revealed that level of training, years practiced, level of advisor education, number of patients supported in a given year, and smoking status had no significant impact on NHS stop smoking advisor quit rate in this sample. However, the model revealed that proportion of time spent delivering smoking cessation support was significantly associated with quit rate. It is imperative that this finding is considered when recruiting, commissioning, and training new smoking cessation advisors or provider organisations.
Elizabeth Sgalitzer Ettinghausen 1918–2016
Authors: Canby Sheila R.
Published: January 2017

Born in Austria in 1918, Elizabeth spent the World War II years in Istanbul where her father was professor of medicine at Istanbul University. This resulted not only in her learning Turkish but also in developing an interest in Byzantine art and archaeology, leading to a dissertation on Byzantine ceramics. In 1945 she married Richard Ettinghausen, who had recently joined the Freer Gallery of Art and was also lecturing at Princeton University. That marked the beginning of Elizabeth's ties with the town where she lived for many years. In 1966 Richard became Hagop Kevorkian Professor of Islamic Art at the Institute of Fine Arts and in 1969 he was appointed Consultative Chairman of the Department of Islamic Art at the Metropolitan Museum of Art. Meanwhile, in addition to pursuing her art–historical interests, Elizabeth was bringing up their two sons in Princeton. Today, the elder son teaches and practices medicine in Rochester, NY, and the younger is in international finance in Abu Dhabi.
From the Editor
Authors: Martin Richard C.
Published: January 2017

This issue of RoMES has been edited in a national atmosphere of anti-Muslim rhetoric, openly expressed by several candidates during the presidential primaries. Now the election campaign has moved to the appointment, by President-Elect, Donald J. Trump, of cabinet members and close advisors, many of whom share his views of the Middle East and its diverse population. And it does not look good for Muslims in America, including Muslims who are U.S. citizens. Along with Hispanics, African Americans, and Jews, Muslims—and indeed the Middle East as such—are regarded as problems that President-Elect Trump seems intent on doing something about. It is a view of Islam and the Middle East shared increasingly in word and deed by a sizeable and vocal portion of the electorate. What are we to make of the possibility of foreign and domestic policy being crafted by the likes of John R. Bolton, who associates Islam with jihadism and is an admirer of the Islamophobic writings of Robert Spencer? Will there be any tolerance in the new Trump administration of debate and the free exchange of ideas on the need for education about and understanding of the Middle East? The importance of this question relates to the growing population of naturalized and second generation citizens of Middle Eastern origins now living in the U.S. The Middle East is here, and contributing to American culture, religious life, economy, and citizenship.
Vitamin A deficiency suppresses fish immune function with differences in different intestinal segments: the role of transcriptional factorNF-κBandp38 mitogen-activated protein kinasesignalling pathways
Authors: Zhang Li , Feng Lin , Jiang Wei-Dan , Liu Yang , Wu Pei , Kuang Sheng-Yao , Tang Ling , Tang Wu-Neng , Zhang Yong-An , Zhou Xiao-Qiu
Published: January 2017

The present study investigated the effects of dietary vitamin A on immune function in the proximal intestine (PI), mid intestine (MI) and distal intestine (DI) of young grass carp (Ctenopharyngodon idella). Fish were fed graded levels of dietary vitamin A for 10 weeks, and then a challenge test using an injection ofAeromonas hydrophilawas conducted for 14 d. The results showed that, compared with the optimum vitamin A level, vitamin A deficiency significantly decreased fish growth performance, increased enteritis morbidity, decreased intestinal innate humoral immune response and aggravated intestinal inflammation. However, liver-expressed antimicrobial peptide 2A/B mRNA in the DI andIL-6,IL-17D,IL-10, transforming growth factor (TGF)-β1andTGF-β2mRNA in the PI were not affected by vitamin A levels. Meanwhile, vitamin A deficiency disturbed inflammatory cytokines in the PI, MI and DI, which might be partly linked to p38 mitogen-activated protein kinase (p38MAPK) signalling andNF-κBcanonical signalling pathway (IκB kinaseβ(IKKβ),IKKγ, inhibitor ofκBα,NF-κB p65andc-Rel) rather thanNF-κBnon-canonical signalling pathway (NF-κB p52andIKKα). However, the signalling moleculesNF-κB p65andp38MAPKdid not participate in regulating cytokines in the PI. These results suggested that vitamin A deficiency decreased fish growth and impaired intestinal immune function, and that different immune responses in the PI, MI and DI were mediated partly byNF-κBcanonical signalling andp38MAPKsignalling pathways. On the basis of percentage of weight gain, to protect fish against enteritis morbidity and acid phosphatase activity, the optimum dietary vitamin A levels were estimated to be 0·664, 0·707 and 0·722 mg /kg, respectively.
Folate and vitamin B12concentrations are associated with plasma DHA and EPA fatty acids in European adolescents: the Healthy Lifestyle in Europe by Nutrition in Adolescence (HELENA) study
Authors: Iglesia I. , Huybrechts I. , González-Gross M. , Mouratidou T. , Santabárbara J. , Chajès V. , González-Gil E. M. , Park J. Y. , Bel-Serrat S. , Cuenca-García M. , Castillo M. , Kersting M. , Widhalm K. , De Henauw S. , Sjöström M. , Gottrand F. , Molnár D. , Manios Y. , Kafatos A. , Ferrari M. , Stehle P. , Marcos A. , Sánchez-Muniz F. J. , Moreno L. A.
Published: January 2017

This study aimed to examine the association between vitamin B6, folate and vitamin B12biomarkers and plasma fatty acids in European adolescents. A subsample from the Healthy Lifestyle in Europe by Nutrition in Adolescence study with valid data on B-vitamins and fatty acid blood parameters, and all the other covariates used in the analyses such as BMI, Diet Quality Index, education of the mother and physical activity assessed by a questionnaire, was selected resulting in 674 cases (43 % males). B-vitamin biomarkers were measured by chromatography and immunoassay and fatty acids by enzymatic analyses. Linear mixed models elucidated the association between B-vitamins and fatty acid blood parameters (changes in fatty acid profiles according to change in 10 units of vitamin B biomarkers). DHA, EPA) andn-3 fatty acids showed positive associations with B-vitamin biomarkers, mainly with those corresponding to folate and vitamin B12. Contrarily, negative associations were found withn-6:n-3 ratio,trans-fatty acids and oleic:stearic ratio. With total homocysteine (tHcy), all the associations found with these parameters were opposite (for instance, an increase of 10 nmol/l in red blood cell folate or holotranscobalamin in females produces an increase of 15·85 µmol/l of EPA (Pvalue <0·01), whereas an increase of 10 nmol/l of tHcy in males produces a decrease of 2·06 µmol/l of DHA (Pvalue <0·05). Positive associations between B-vitamins and specific fatty acids might suggest underlying mechanisms between B-vitamins and CVD and it is worth the attention of public health policies.
Effect of maternal dietary counselling during the 1st year of life on glucose profile and insulin resistance at the age of 8 years: a randomised field trial
Authors: Costa Cintia S. , Campagnolo Paula D. B. , Lumey L. H. , Vitolo Marcia R.
Published: January 2017

Education interventions that stimulate complementary feeding practices can improve the nutritional status of children and may protect against future chronic diseases. We assessed the long-term effectiveness of dietary intervention during the 1st year of life on insulin resistance levels, and investigated the relationship between insulin resistance and weight changes over time. A randomised field trial was conducted among 500 mothers who gave birth to full-term infants between October 2001 and June 2002 in a low-income area in São Leopoldo, Brazil. Mother–child pairs were randomly assigned to intervention (n 200) and control groups (n 300), and the mothers in the intervention group received dietary counselling on breast-feeding and complementary feeding of their children during the 1st year of life. Fieldworkers blinded to assignment assessed socio-demographic, dietary and anthropometric data during follow-up at ages 1, 4 and 8 years. Blood tests were performed in 305 children aged 8 years to measure fasting serum glucose and insulin concentrations and the homoeostasis model assessment index of insulin resistance (HOMA-IR). At the age of 8 years, the intervention group showed no changes in glucose and insulin concentrations or HOMA-IR values (change 0·07; 95 % CI −0·06, 0·21 for girls; and change −0·07; 95 % CI −0·19, 0·04 for boys) compared with study controls. Insulin resistance was highly correlated, however, with increases in BMI between birth and 8 years of age. Although this dietary intervention had no impact on glucose profile at age 8 years, our findings suggest that BMI changes in early childhood can serve as an effective marker of insulin resistance.
Has Simeon's Vision Prevailed among Canadian Policy Scholars?
Authors: Montpetit Éric , Rothmayr Allison Christine , Engeli Isabelle
Published: January 2017

Concerned by the proliferation of idiosyncratic prescriptive case studies in the nascent subfield of policy studies, Richard Simeon, in his seminal 1976 article, asked scholars to produce more comparative policy research that aimed at explaining general events and contributing to theory building. The extent to which Simeon's vision materialized remains debated. With a view to informing this debate, we conducted a systematic content analysis of the articles published in five major generalist public policy journals from 1980 to 2015. The analysis reveals that Canadian policy scholars took a comparative turn, publishing more territorial, sector and time comparisons than in the past. We also found evidence that theoretical knowledge accumulation is more important today for Canadian authors than it was when Simeon wrote his article.
Monuments, Kitsch, and the Sense of Nation in Imperial Germany
Authors: Smith Helmut Walser
Published: January 2017

This article shows how the material culture of nationhood can reveal a different perspective on the problem of nationalism. Using simple time graphs and Geographic Information Systems (GIS), the article considers temporal and spatial dimensions of “nation objects” in an effort to understand the allusive phenomenon of banal, everyday national identity. Specifically, it brings together quantitative evidence for the pervasiveness of veterans monuments, Kaiser Wilhelm I and Otto von Bismarck monuments, as well as monuments to Germany's great intellectuals, and then examines the world of objects, largely kitsch, that these monuments brought forth. The article argues that, especially in small-town Germany, objects signifying the nation point to a national sentiment governed less by the sharp logic of ideology than by the harmonizing tendencies of kitsch.

Dieser Aufsatz zeigt, wie die materielle Kultur der nationalen Einheit eine andere Perspektive auf das Problem des Nationalismus bieten kann. Durch die Verwendung einfacher Zeitgraphiken und Geographic Information Systems (GIS) werden die zeitlichen und räumlichen Dimensionen von “Nationalobjekten” betrachtet, um das anspielungsreiche Phänomen banaler, alltäglicher Nationalidentität zu begreifen. Konkret werden quantitative Nachweise weit verbreiteter Kriegsdenkmäler, Denkmäler für Kaiser Wilhelm I. und Otto von Bismarck sowie Denkmäler für Deutschlands führende Intellektuelle zusammengeführt und im Anschluss daran die Welt der Objekte – größtenteils Kitsch –, die diese Denkmäler hervorgebracht haben, untersucht. Dabei wird argumentiert, dass diese die Nation repräsentierenden Objekte vor allem im kleinstädtischen Deutschland auf ein Nationalgefühl verweisen, das weniger durch klar definierte Ideologie als vielmehr durch die harmonisierenden Tendenzen von Kitsch bestimmt ist.
A remarkable, endohymenial species ofArthothelium(Arthoniales) from Campbell Island, New Zealand
Authors: ERTZ Damien , FRYDAY Alan M.
Published: January 2017

A newArthotheliumspecies,A. hymeniicolain the apothecia of an unidentifiedBacidiasp., is described from Campbell Island, New Zealand. The new species is remarkable, not only by being the first lichenicolousArthotheliumspecies, but also by being an endohymenial fungus not forming ascomatal structures. Previously, noArthoniaceaespecies were reported as parasitic fromBacidiaspp. However, both generic and family placements are tentative and the possibility of a placement in theCookellaceaeis also discussed. Differences betweenArthoniaceaeandCookellaceae, and the generic delimitations within them, are generally based on the structures of the fruiting bodies, rendering the taxonomic placement of the new species challenging without molecular data; neither fruiting bodies nor molecular data are available for the new species and theCookellaceae.
Two new species in theMicarea prasinagroup from Western Europe
Authors: VAN DEN BOOM Pieter P. G. , BRAND A. Maarten , COPPINS Brian J. , SÉRUSIAUX Emmanuël
Published: January 2017

Detailed morphological and anatomical studies informed by molecular inferences with mtSSU as a marker revealed two new species ofMicareain Western Europe, both belonging to the core group of the genus, namely theM. prasinagroup:M. herbarumfrom the Netherlands and Poland andM. meridionalisfrom Portugal and Italy.Micarea herbarumlooks like a small or depauperateM. denigratabut clearly differs by the lack of gyrophoric acid, whileM. meridionalisis distinguished by its granular thallus and the production of micareic acid.
Semantic Facts and a Priori Knowledge
Authors: Nyseth Fredrik
Published: January 2017

This paper is a response to a paper by Marcus Giaquinto in which he argues that lexical meaning is moderately indeterminate and that this poses a problem for the linguistic view of a priori knowledge. I argue that accepting the moderate indeterminacy thesis as he presents it is perfectly compatible with both the linguistic view in general and the specific suggestion that some a priori knowledge can be explained by appealing to synonymy. I also argue that, in fact, Giaquinto's considerations speak in favour of the linguistic view rather than against it. The general lesson is that, contrary to what might be suspected, the linguistic view does not presuppose an implausibly simple and tidy conception of lexical meaning.
English medium instruction: Global views and countries in focus
Authors: Macaro Ernesto , Hultgren Anna Kristina , Kirkpatrick Andy , Lasagabaster David
Published: January 2017

In virtually every research paper on this topic we come across we read that, in the particular context that the writer is operating, English as a medium of instruction (EMI) is on the increase. But what exactly is EMI? If we consider every classroom around the world in which learners are exposed to English language as their second language (L2) we are faced with a huge variety: English as a foreign language (EFL); Immersion, English for academic purposes; English for specific purposes, English for examination purposes, Content and language integrated learning (CLIL); content-based teaching; content-based language teaching, and so on. And then we have EMI. Here at the EMI Oxford Centre we define EMI as:

The use of the English language to teach academic subjects (other than English itself) in countries or jurisdictions in which the majority of the population's first language is not English.

This definition was first used in Dearden (2015).
A cooperative search for berth scheduling
Authors: Lalla-Ruiz Eduardo , Melián-Batista Belén , Moreno-Vega José Marcos
Published: January 2017

With the growing demand of freight transport by means of container vessels as well as the important competition among terminals, managers and stakeholders seek to improve the exploitation of the container terminal resources efficiently. In this context, arises the Berth Allocation Problem, which aims to allocate and schedule incoming vessels along the quay. Its appropriate solution plays a relevant role in enhancing the terminal productivity. Thus, for addressing this problem, we propose a cooperative search, where the individuals are organized into groups and each member shares information with its group partners. This grouping strategy allows to diversify as well as intensify the search in some regions by means of information shared among the individuals of each group. The computational experiments for this problem reveal that our approach reports high-quality solutions and identifies promising regions within the search space in short computational times.
The provision of healthy food in a school tuck shop: does it influence primary-school students’ perceptions, attitudes and behaviours towards healthy eating?
Authors: Bekker Francette , Marais Maritha , Koen Nelene
Published: January 2017

Objective

To investigate students’ tuck shop buying behaviour, choices of lunchbox items and healthy eating perceptions and attitudes at a school with a nutritionally regulated tuck shop and a school with a conventional tuck shop.

Design

Mixed-methods research comprising a cross-sectional survey and focus groups.

Setting

Bloemfontein, South Africa.

Subjects

Randomly selected grade 2 to 7 students from a school with a nutritionally regulated tuck shop (school A; n 116) and a school with a conventional tuck shop (school B; n 141) completed a self-administered questionnaire about perceptions, attitudes, buying behaviours and lunchbox content. Six students per grade (n 72) in each school took part in focus group discussions to further explore concepts pertaining to healthy eating.

Results

In school A, older students had a negative attitude towards their ‘healthy’ tuck shop, while younger students were more positive. School B students were positive towards their conventional tuck shop. In both schools students wanted their tuck shop to allow them to choose from healthy and unhealthy items. School A students mostly bought slushies, iced lollies and baked samoosas, while school B students mostly bought sweets and crisps. The lunchboxes of school A students contained significantly (P<0·05) more healthy items but also significantly more unhealthy items.

Conclusions

A single intervention such as having a nutritionally regulated tuck shop at a primary school cannot advance the healthy school food environment in its totality. A multi-pronged approach is recommended and awareness must be created among all role players, including parents who are responsible for preparing lunchboxes.
Anger Rumination Scale: Validation in Mexico
Authors: Ortega Andrade Norma , Alcázar-Olán Raúl , Matías Oscar Mariano , Rivera Guerrero Ana , Domínguez Espinosa Alejandra
Published: January 2017

The aim of the study was to assess the validity of the Anger Rumination Scale (ARS; Sukhodolsky, Golub, & Cromwell, 2001) in a Mexican sample (n = 700, Mage = 38.6, SD = 12.42). Through confirmatory factor analysis and using modification indices, the four-factor structure of the original scale was replicated: angry afterthoughts, thoughts of revenge, angry memories, and understanding of causes. In addition, the four-factor model had better goodness of fit indices than rival models with three and two factors. Alpha reliabilities were acceptable (.72 –.89). ARS results correlated with measures of state anger, trait anger, anger expression, and anger control (negatively); correlations were significant (ps < .001) ARS outcomes also correlated (ps < .001) with physical and verbal aggression, hostility, anger, and emotion suppression, suggesting convergent validity. Men reported more thoughts of revenge than women (p < .001; Eta squared = .026), but there was no evidence of gender differences on the other anger rumination scales, or in total scores.
Understanding Causes and Effects of Rapid Warming in the Arctic
Authors: Wendisch Manfred , Brückner Marlen , Burrows John , Crewell Susanne , Dethloff Klaus , Ebell Kerstin , Lüpkes Christof , Macke Andreas , Notholt Justus , Quaas Johannes , Rinke Annette , Tegen Ina
Published: January 2017

A new German research consortium is investigating why near-surface air temperatures in the Artic are rising more quickly than in the rest of the world.
Uncovering the SUMOylation and ubiquitylation crosstalk in human cells using sequential peptide immunopurification
Authors: Lamoliatte Frédéric , McManus Francis P. , Maarifi Ghizlane , Chelbi-Alix Mounira K. , Thibault Pierre
Published: January 2017

Crosstalk between the SUMO and ubiquitin pathways has recently been reported. However, no approach currently exists to determine the interrelationship between these modifications. Here, we report an optimized immunoaffinity method that permits the study of both protein ubiquitylation and SUMOylation from a single sample. This method enables the unprecedented identification of 10,388 SUMO sites in HEK293 cells. The sequential use of SUMO and ubiquitin remnant immunoaffinity purification facilitates the dynamic profiling of SUMOylated and ubiquitylated proteins in HEK293 cells treated with the proteasome inhibitor MG132. Quantitative proteomic analyses reveals crosstalk between substrates that control protein degradation, and highlights co-regulation of SUMOylation and ubiquitylation levels on deubiquitinase enzymes and the SUMOylation of proteasome subunits. The SUMOylation of the proteasome affects its recruitment to promyelocytic leukemia protein (PML) nuclear bodies, and PML lacking the SUMO interacting motif fails to colocalize with SUMOylated proteasome further demonstrating that this motif is required for PML catabolism.
Origin and evolution of the deep thermochemical structure beneath Eurasia
Authors: Flament N. , Williams S. , Müller R. D. , Gurnis M. , Bower D. J.
Published: January 2017

A unique structure in the Earth’s lowermost mantle, the Perm Anomaly, was recently identified beneath Eurasia. It seismologically resembles the large low-shear velocity provinces (LLSVPs) under Africa and the Pacific, but is much smaller. This challenges the current understanding of the evolution of the plate–mantle system in which plumes rise from the edges of the two LLSVPs, spatially fixed in time. New models of mantle flow over the last 230 million years reproduce the present-day structure of the lower mantle, and show a Perm-like anomaly. The anomaly formed in isolation within a closed subduction network ∼22,000 km in circumference prior to 150 million years ago before migrating ∼1,500 km westward at an average rate of 1 cm year−1, indicating a greater mobility of deep mantle structures than previously recognized. We hypothesize that the mobile Perm Anomaly could be linked to the Emeishan volcanics, in contrast to the previously proposed Siberian Traps.
Carbon translocation from a plant to an insect-pathogenic endophytic fungus
Authors: Behie Scott W. , Moreira Camila C. , Sementchoukova Irina , Barelli Larissa , Zelisko Paul M. , Bidochka Michael J.
Published: January 2017

Metarhizium robertsii is a common soil fungus that occupies a specialized ecological niche as an endophyte and an insect pathogen. Previously, we showed that the endophytic capability and insect pathogenicity of Metarhizium are coupled to provide an active method of insect-derived nitrogen transfer to a host plant via fungal mycelia. We speculated that in exchange for this insect-derived nitrogen, the plant would provide photosynthate to the fungus. By using 13CO2, we show the incorporation of 13C into photosynthate and the subsequent translocation of 13C into fungal-specific carbohydrates (trehalose and chitin) in the root/endophyte complex. We determined the amount of 13C present in root-associated fungal biomass over a 21-day period by extracting fungal carbohydrates and analysing their composition using nuclear magnetic resonance (NMR) spectroscopy. These findings are evidence that the host plant is providing photosynthate to the fungus, likely in exchange for insect-derived nitrogen in a tripartite, and symbiotic, interaction.
Erratum: Global gain modulation generates time-dependent urgency during perceptual choice in humans
Authors: Murphy Peter R , Boonstra Evert , Nieuwenhuis Sander
Published: January 2017

Nature Communications 7: Article number: 13526 (2016); Published: 24 November 2016; Updated: 18 January 2017 In Fig. 4c of this Article, the colour bars were inadvertently changed from graded to solid during the production process. The correct version of Fig. 4c appears below as Fig. 1.
Deficiency of angiotensin-converting enzyme 2 causes deterioration of cognitive function
Authors: Wang Xiao-Li , Iwanami Jun , Min Li-Juan , Tsukuda Kana , Nakaoka Hirotomo , Bai Hui-Yu , Shan Bao-Shuai , Kan-no Harumi , Kukida Masayoshi , Chisaka Toshiyuki , Yamauchi Toshifumi , Higaki Akinori , Mogi Masaki , Horiuchi Masatsugu
Published: January 2017

The classical renin–angiotensin system (RAS), known as the angiotensin (Ang)-converting enzyme (ACE)/Ang II/Ang II type 1 (AT1) receptor axis, induces various organ damages including cognitive decline. On the other hand, the ACE2/Ang-(1–7)/Mas receptor axis has been highlighted as exerting antagonistic actions against the classical RAS axis in the cardiovascular system. However, the roles of the ACE2/Ang-(1–7)/Mas axis in cognitive function largely remain to be elucidated, and we therefore examined possible roles of ACE2 in cognitive function. Male, 10-week-old C57BL6 (wild type, WT) mice and ACE2 knockout (KO) mice were subjected to the Morris water maze task and Y maze test to evaluate cognitive function. ACE2KO mice exhibited significant impairment of cognitive function, compared with that in WT mice. Superoxide anion production increased in ACE2KO mice, with increased mRNA levels of NADPH oxidase subunit, p22phox, p40phox, p67phox, and gp91phox in the hippocampus of ACE2KO mice compared with WT mice. The protein level of SOD3 decreased in ACE2KO mice compared with WT mice. The AT1 receptor mRNA level in the hippocampus was higher in ACE2KO mice compared with WT mice. In contrast, the AT2 receptor mRNA level in the hippocampus did not differ between the two strains. Mas receptor mRNA was highly expressed in the hippocampus compared with the cortex. Brain-derived neurotrophic factor (BDNF) mRNA and protein levels were lower in the hippocampus in ACE2KO mice compared with WT mice. Taken together, ACE2 deficiency resulted in impaired cognitive function, probably at least in part because of enhanced oxidative stress and a decrease in BDNF.
Yeast longevity promoted by reversing aging-associated decline in heavy isotope content
Authors: Li Xiyan , Snyder Michael P
Published: January 2017

Dysregulation of metabolism develops with organismal aging. Both genetic and environmental manipulations promote longevity by effectively diverting various metabolic processes against aging. How these processes converge on the metabolome is not clear. Here we report that the heavy isotopic forms of common elements, a universal feature of metabolites, decline in yeast cells undergoing chronological aging. Supplementation of deuterium, a heavy hydrogen isotope, through heavy water (D2O) uptake extends yeast chronological lifespan (CLS) by up to 85% with minimal effects on growth. The CLS extension by D2O bypasses several known genetic regulators, but is abrogated by calorie restriction and mitochondrial deficiency. Heavy water substantially suppresses endogenous generation of reactive oxygen species (ROS) and slows the pace of metabolic consumption and disposal. Protection from aging by heavy isotopes might result from kinetic modulation of biochemical reactions. Altogether, our findings reveal a novel perspective of aging and new means for promoting longevity.
Pericytes from Mesenchymal Stem Cells as a model for the blood-brain barrier
Authors: Tian Xiaohe , Brookes Oliver , Battaglia Giuseppe
Published: January 2017

Blood brain-barrier (BBB) in vitro models have been widely reported in studies of the BBB phenotype. However, established co-culture systems involve brain endothelial cells, astrocytes, neurons and pericytes, and therefore are often consuming and technically challenging. Here we use mesenchymal system cells (MSC) as a potential substitute for pericytes in a BBB model. Both MSC and pericyte markers in 2D culture environment were evaluated on different extracellular matrix compositions. Further experiments indicated that MSC contributed in a similar manner to pericytes in a co-cultured 3D model on increasing trans-endothelial electric resistance (TEER) and decreasing permeability against macromolecules.
A ZIP6-ZIP10 heteromer controls NCAM1 phosphorylation and integration into focal adhesion complexes during epithelial-to-mesenchymal transition
Authors: Brethour Dylan , Mehrabian Mohadeseh , Williams Declan , Wang Xinzhu , Ghodrati Farinaz , Ehsani Sepehr , Rubie Elizabeth A. , Woodgett James R. , Sevalle Jean , Xi Zhengrui , Rogaeva Ekaterina , Schmitt-Ulms Gerold
Published: January 2017

The prion protein (PrP) evolved from the subbranch of ZIP metal ion transporters comprising ZIPs 5, 6 and 10, raising the prospect that the study of these ZIPs may reveal insights relevant for understanding the function of PrP. Building on data which suggested PrP and ZIP6 are critical during epithelial-to-mesenchymal transition (EMT), we investigated ZIP6 in an EMT paradigm using ZIP6 knockout cells, mass spectrometry and bioinformatic methods. Reminiscent of PrP, ZIP6 levels are five-fold upregulated during EMT and the protein forms a complex with NCAM1. ZIP6 also interacts with ZIP10 and the two ZIP transporters exhibit interdependency during their expression. ZIP6 contributes to the integration of NCAM1 in focal adhesion complexes but, unlike cells lacking PrP, ZIP6 deficiency does not abolish polysialylation of NCAM1. Instead, ZIP6 mediates phosphorylation of NCAM1 on a cluster of cytosolic acceptor sites. Substrate consensus motif features andin vitrophosphorylation data point toward GSK3 as the kinase responsible, and interface mapping experiments identified histidine-rich cytoplasmic loops within the ZIP6/ZIP10 heteromer as a novel scaffold for GSK3 binding. Our data suggests that PrP and ZIP6 inherited the ability to interact with NCAM1 from their common ZIP ancestors but have since diverged to control distinct posttranslational modifications of NCAM1.
Immunoglobulin light chain (IGL) genes in torafugu: Genomic organization and identification of a third teleost IGL isotype
Authors: Fu Xi , Zhang Fengjun , Watabe Shugo , Asakawa Shuichi
Published: January 2017

Here, we report a genome-wide survey of immunoglobulin light chain (IGL) genes of torafugu (Takifugu rubripes) revealing multi-clusters spanning three separate chromosomes (v5 assembly) and 45 scaffolds (v4 assembly). Conventional sequence similarity searches and motif scanning approaches based on recombination signal sequence (RSS) motifs were used. We found that three IGL isotypes (L1, L2, and L3) exist in torafugu and that several loci for each isotype are present. The transcriptional orientations of the variable IGL (VL) segments were found to be either the same (in the L2 isotype) or opposite (in the L1 and L3 isotypes) to the IGL joining (JL) and constant (CL) segments, suggesting they can undergo rearrangement by deletion or inversion when expressed. Alignments of expressed sequence tags (ESTs) to corresponding germline gene segments revealed expression of the three IGL isotypes in torafugu. Taken together, our findings provide a genomic framework for torafugu IGL genes and show that the IG diversity of this species could be attributed to at least three distinct chromosomal regions.
Nanoscale measurement of trace element distributions in Spartina alterniflora root tissue during dormancy
Authors: Feng Huan , Qian Yu , Cochran J. Kirk , Zhu Qingzhi , Hu Wen , Yan Hanfei , Li Li , Huang Xiaojing , Chu Yong S. , Liu Houjun , Yoo Shinjae , Liu Chang-Jun
Published: January 2017

This paper reports a nanometer-scale investigation of trace element (As, Ca, Cr, Cu, Fe, Mn, Ni, S and Zn) distributions in the root system Spartina alterniflora during dormancy. The sample was collected on a salt marsh island in Jamaica Bay, New York, in April 2015 and the root was cross-sectioned with 10 μm resolution. Synchrotron X-ray nanofluorescence was applied to map the trace element distributions in selected areas of the root epidermis and endodermis. The sampling resolution was 60 nm to increase the measurement accuracy and reduce the uncertainty. The results indicate that the elemental concentrations in the epidermis, outer endodermis and inner endodermis are significantly (p < 0.01) different. The root endodermis has relatively higher concentrations of these elements than the root epidermis. Furthermore, this high resolution measurement indicates that the elemental concentrations in the outer endodermis are significantly (p < 0.01) higher than those in the inner endodermis. These results suggest that the Casparian strip may play a role in governing the aplastic transport of these elements. Pearson correlation analysis on the average concentrations of each element in the selected areas shows that most of the elements are significantly (p < 0.05) correlated, which suggests that these elements may share the same transport pathways.
Carbon elimination from silicon kerf: Thermogravimetric analysis and mechanistic considerations
Authors: Vazquez-Pufleau Miguel , Chadha Tandeep S. , Yablonsky Gregory , Biswas Pratim
Published: January 2017

40% of ultrapure silicon is lost as kerf during slicing to produce wafers. Kerf is currently not being recycled due to engineering challenges and costs associated with removing its abundant impurities. Carbon left behind from the lubricant remains as one of the most difficult contaminants to remove in kerf without significant silicon oxidation. The present work enables to better understand the mechanism of carbon elimination in kerf which can aid the design of better processes for kef recycling and low cost photovoltaics. In this paper, we studied the kinetics of carbon elimination from silicon kerf in two atmospheres: air and N2, under a regime of no-diffusion-limitation. We report the apparent activation energy in both atmospheres using three methods: Kissinger, and two isoconversional approaches. In both atmospheres, a bimodal apparent activation energy is observed, suggesting a two stage process. A reaction mechanism is proposed in which (a) C-C and C-O bond cleavage reactions occur in parallel with polymer formation; (b) at higher temperatures, this polymer fully degrades in air but leaves a tarry residue in N2 that accounts for about 12% of the initial total carbon.
Stochastic evolution in populations of ideas
Authors: Nicole Robin , Sollich Peter , Galla Tobias
Published: January 2017

It is known that learning of players who interact in a repeated game can be interpreted as an evolutionary process in a population of ideas. These analogies have so far mostly been established in deterministic models, and memory loss in learning has been seen to act similarly to mutation in evolution. We here propose a representation of reinforcement learning as a stochastic process in finite ‘populations of ideas’. The resulting birth-death dynamics has absorbing states and allows for the extinction or fixation of ideas, marking a key difference to mutation-selection processes in finite populations. We characterize the outcome of evolution in populations of ideas for several classes of symmetric and asymmetric games.
Crystal growth of Dirac semimetal ZrSiS with high magnetoresistance and mobility
Authors: Sankar Raman , Peramaiyan G. , Muthuselvam I. Panneer , Butler Christopher J. , Dimitri Klauss , Neupane Madhab , Rao G. Narsinga , Lin M.-T. , Chou F. C.
Published: January 2017

High quality single crystal ZrSiS as a theoretically predicted Dirac semimetal has been grown successfully using a vapor phase transport method. The single crystals of tetragonal structure are easy to cleave into perfect square-shaped pieces due to the van der Waals bonding between the sulfur atoms of the quintuple layers. Physical property measurement results including resistivity, Hall coefficient (RH), and specific heat are reported. The transport and thermodynamic properties suggest a Fermi liquid behavior with two Fermi pockets at low temperatures. At T = 3 K and magnetic field of Hǁc up to 9 Tesla, large magneto-resistance up to 8500% and 7200% for Iǁ(100) and Iǁ(110) were found. Shubnikov de Haas (SdH) oscillations were identified from the resistivity data, revealing the existence of two Fermi pockets at the Fermi level via the fast Fourier transform (FFT) analysis. The Hall coefficient (RH) showed hole-dominated carriers with a high mobility of 3.05 × 104 cm2V−1s−1 at 3 K. ZrSiS has been confirmed to be a Dirac semimetal by the Dirac cone mapping near the X-point via angle resolved photoemission spectroscopy (ARPES) with a Dirac nodal line near the Fermi level identified using scanning tunneling spectroscopy (STS).
Correlated electronic decay in expanding clusters triggered by intense XUV pulses from a Free-Electron-Laser
Authors: Oelze Tim , Schütte Bernd , Müller Maria , Müller Jan P. , Wieland Marek , Frühling Ulrike , Drescher Markus , Al-Shemmary Alaa , Golz Torsten , Stojanovic Nikola , Krikunova Maria
Published: January 2017

Irradiation of nanoscale clusters and large molecules with intense laser pulses transforms them into highly-excited non- equilibrium states. The dynamics of intense laser-cluster interaction is encoded in electron kinetic energy spectra, which contain signatures of direct photoelectron emission as well as emission of thermalized nanoplasma electrons. In this work we report on a so far not observed spectrally narrow bound state signature in the electron kinetic energy spectra from mixed Xe core - Ar shell clusters ionized by intense extreme-ultraviolet (XUV) pulses from a free-electron-laser. This signature is attributed to the correlated electronic decay (CED) process, in which an excited atom relaxes and the excess energy is used to ionize the same or another excited atom or a nanoplasma electron. By applying the terahertz field streaking principle we demonstrate that CED-electrons are emitted at least a few picoseconds after the ionizing XUV pulse has ended. Following the recent finding of CED in clusters ionized by intense near-infrared laser pulses, our observation of CED in the XUV range suggests that this process is of general relevance for the relaxation dynamics in laser produced nanoplasmas.