bluuebunny/crossref_metadata_2025 huggingface dataset:
Scalable, fiber-compatible lithium-niobate-on-insulator micro-waveguides for efficient nonlinear photonics
Authors: Zhang Yuting , Li Hao , Ding Tingting , Huang Yiwen , Liang Longyue , Sun Xuerui , Tang Yongzhi , Wang Jiayu , Liu Shijie , Zheng Yuanlin , Chen Xianfeng
Published: May 2023

Efficient wave mixers based on lithium-niobate-on-insulator (LNOI) hold great potential for next-generation photonic integrated circuits in both classical and quantum optics. However, achieving high-performance nonlinear photonic devices readily suitable for scalable, fiber-compatible applications remains challenging. Here, we report on the fabrication of LNOI micrometer waveguides, i.e., micro-waveguides, with a combination of ultraviolet lithography and deep dry etching technology for efficient nonlinear photonics applications. We fabricate periodically poled LNOI micro-waveguides with a cross section of ∼3×4µm2 and demonstrate a fiber–chip–fiber second-harmonic generation conversion efficiency of 1320%/W with an insertion loss of 3.8 dB at the telecommunication band. We also demonstrate high-quality photon pair generation via spontaneous parametric downconversion with a flux of 178 MHz/mW at sub-mW pump power and coincidence-to-accidental ratio >8000 at microwatt pump power. The overall performance in both applications is on par with that of state-of-the-art counterparts using thin-film lithium niobate nano-waveguides. The technique would make micrometer-thick LNOI an attractive platform for ready applications in nonlinear and quantum optics.
Streptothricin F is a bactericidal antibiotic effective against highly drug-resistant gram-negative bacteria that interacts with the 30S subunit of the 70S ribosome
Authors: Morgan Christopher E. , Kang Yoon-Suk , Green Alex B. , Smith Kenneth P. , Dowgiallo Matthew G. , Miller Brandon C. , Chiaraviglio Lucius , Truelson Katherine A. , Zulauf Katelyn E. , Rodriguez Shade , Kang Anthony D. , Manetsch Roman , Yu Edward W. , Kirby James E.
Published: May 2023

The streptothricin natural product mixture (also known as nourseothricin) was discovered in the early 1940s, generating intense initial interest because of excellent gram-negative activity. Here, we establish the activity spectrum of nourseothricin and its main components, streptothricin F (S-F, 1 lysine) and streptothricin D (S-D, 3 lysines), purified to homogeneity, against highly drug-resistant, carbapenem-resistant Enterobacterales (CRE) and Acinetobacter baumannii. For CRE, the MIC50 and MIC90 for S-F and S-D were 2 and 4 μM, and 0.25 and 0.5 μM, respectively. S-F and nourseothricin showed rapid, bactericidal activity. S-F and S-D both showed approximately 40-fold greater selectivity for prokaryotic than eukaryotic ribosomes in in vitro translation assays. In vivo, delayed renal toxicity occurred at >10-fold higher doses of S-F compared with S-D. Substantial treatment effect of S-F in the murine thigh model was observed against the otherwise pandrug-resistant, NDM-1-expressing Klebsiella pneumoniae Nevada strain with minimal or no toxicity. Cryo-EM characterization of S-F bound to the A. baumannii 70S ribosome defines extensive hydrogen bonding of the S-F steptolidine moiety, as a guanine mimetic, to the 16S rRNA C1054 nucleobase (Escherichia coli numbering) in helix 34, and the carbamoylated gulosamine moiety of S-F with A1196, explaining the high-level resistance conferred by corresponding mutations at the residues identified in single rrn operon E. coli. Structural analysis suggests that S-F probes the A-decoding site, which potentially may account for its miscoding activity. Based on unique and promising activity, we suggest that the streptothricin scaffold deserves further preclinical exploration as a potential therapeutic for drug-resistant, gram-negative pathogens.
What interventions are effective to prevent or respond to female genital mutilation? A review of existing evidence from 2008–2020
Authors: Matanda Dennis Juma , Van Eekert Nina , Croce-Galis Melanie , Gay Jill , Middelburg Maria Johanna , Hardee Karen
Published: May 2023

As the final decade of acceleration towards zero new cases of Female Genital Mutilation (FGM, SDG Target 5.3) by 2030 has begun, increasing the rigour, relevance, and utility of research for programming, policy development and resource allocation is critical. This study aimed to synthesize and assess the quality and strength of existing evidence on interventions designed to prevent or respond to FGM between 2008 and 2020.The study drew on a Rapid Evidence Assessment of the available literature on FGM interventions. The quality of studies was assessed using the ‘How to Note: Assessing the Strength of Evidence’ guidelines published by the Foreign, Commonwealth and Development Office (FCDO) and strength of evidence using a modified Gray scale developed by the What Works Association. Of the 7698 records retrieved, 115 studies met the inclusion criteria. Of the 115 studies, 106 were of high and moderate quality and were included in the final analysis. This review shows that at the system level, legislation-related interventions must be multifaceted to be effective. Whilst all levels would benefit from more research, for the service level especially more research is needed into how the health system can effectively prevent and respond to FGM. Community-level interventions are effective for changing attitudes towards FGM, but more must be done to innovate with these interventions so that they move beyond affecting attitudes alone to creating behaviour change. At the individual level, formal education is effective in reducing FGM prevalence among girls. However, the returns of formal education in ending FGM may take many years to be realized. Interventions targeting intermediate outcomes, such as improvement in knowledge and change in attitudes and beliefs towards FGM, are equally needed at the individual level.
Exploring Prajnamitra Maitreya Buddhists School Pekanbaru: Do leadership, work environment, and organisational culture influence the teachers’ competence and work performance?
Authors: Mohamed Sultan Fazal Mohamed , Karuppannan Gunasegaran , Nyoto  , Lestari Herni
Published: May 2023

School administration must pay attention to professional teachers’ roles rather than nonprofessional teachers as part of important human resources in imparting learning. This study aims to analyse the influence of leadership, work environment, and organisational culture on the teachers’ competence and performance in Prajnamitra Maitreya Foundation Pekanbaru, Indonesia. A total of 57 teachers participated in this research. A descriptive analysis of questionnaires and hypothesis analysis using path analysis was used to analyse the data from the saturated sampling method, where 57 teachers became the sample and were categorised based on age, gender, level of education, years of service, and work unit. Using Smart PLS (Partial Least Squares), this research revealed that leadership and work environment positively but non-significant affect the teachers’ competence. Meanwhile, organisational culture has a positive and significant effect on the teachers’ competence but a non-significant positive effect on the teachers’ performance. Thus, the work environment and teacher’s competence have a positive and significant effect on the teacher’s performance, yet leadership has a negative and non-significant effect on the teacher’s performance.
Fully automated calcium scoring predicts all-cause mortality at 12 years in the MILD lung cancer screening trial
Authors: Sabia Federica , Balbi Maurizio , Ledda Roberta E. , Milanese Gianluca , Ruggirello Margherita , Valsecchi Camilla , Marchianò Alfonso , Sverzellati Nicola , Pastorino Ugo
Published: May 2023

Coronary artery calcium (CAC) is a known risk factor for cardiovascular (CV) events and mortality but is not yet routinely evaluated in low-dose computed tomography (LDCT)-based lung cancer screening (LCS). The present analysis explored the capacity of a fully automated CAC scoring to predict 12-year mortality in the Multicentric Italian Lung Detection (MILD) LCS trial. The study included 2239 volunteers of the MILD trial who underwent a baseline LDCT from September 2005 to January 2011, with a median follow-up of 190 months. The CAC score was measured by a commercially available fully automated artificial intelligence (AI) software and stratified into five strata: 0, 1–10, 11–100, 101–400, and > 400. Twelve-year all-cause mortality was 8.5% (191/2239) overall, 3.2% with CAC = 0, 4.9% with CAC = 1–10, 8.0% with CAC = 11–100, 11.5% with CAC = 101–400, and 17% with CAC > 400. In Cox proportional hazards regression analysis, CAC > 400 was associated with a higher 12-year all-cause mortality both in a univariate model (hazard ratio, HR, 5.75 [95% confidence interval, CI, 2.08–15.92] compared to CAC = 0) and after adjustment for baseline confounders (HR, 3.80 [95%CI, 1.35–10.74] compared to CAC = 0). All-cause mortality significantly increased with increasing CAC (7% in CAC ≤ 400 vs. 17% in CAC > 400, Log-Rank p-value <0.001). Non-cancer at 12 years mortality was 3% (67/2239) overall, 0.8% with CAC = 0, 1.0% with CAC = 1–10, 2.9% with CAC = 11–100, 3.6% with CAC = 101–400, and 8.2% with CAC > 400 (Grey’s test p < 0.001). In Fine and Gray’s competing risk model, CAC > 400 predicted 12-year non-cancer mortality in a univariate model (sub-distribution hazard ratio, SHR, 10.62 [95% confidence interval, CI, 1.43–78.98] compared to CAC = 0), but the association was no longer significant after adjustment for baseline confounders. In conclusion, fully automated CAC scoring was effective in predicting all-cause mortality at 12 years in a LCS setting.
Cytosolic EpCAM cooperates with H-Ras to regulate epithelial to mesenchymal transition through ZEB1
Authors: Omar Fatma A. , Brown Taylor C. , Gillanders William E. , Fleming Timothy P. , Smith Michael A. , Bremner Ross M. , Sankpal Narendra V.
Published: May 2023

Next generation sequencing of human cancer mutations has identified novel therapeutic targets. Activating Ras oncogene mutations play a central role in oncogenesis, and Ras-driven tumorigenesis upregulates an array of genes and signaling cascades that can transform normal cells into tumor cells. In this study, we investigated the role of altered localization of epithelial cell adhesion molecule (EpCAM) in Ras-expressing cells. Analysis of microarray data demonstrated that Ras expression induced EpCAM expression in normal breast epithelial cells. Fluorescent and confocal microscopy showed that H-Ras mediated transformation also promoted epithelial-to-mesenchymal transition (EMT) together with EpCAM. To consistently localize EpCAM in the cytosol, we generated a cancer-associated EpCAM mutant (EpCAM-L240A) that is retained in the cytosol compartment. Normal MCF-10A cells were transduced with H-Ras together with EpCAM wild-type (WT) or EpCAM-L240A. WT-EpCAM marginally effected invasion, proliferation, and soft agar growth. EpCAM-L240A, however, markedly altered cells and transformed to mesenchymal phenotype. Ras-EpCAM-L240A expression also promoted expression of EMT factors FRA1, ZEB1 with inflammatory cytokines IL-6, IL-8, and IL1. This altered morphology was reversed using MEK-specific inhibitors and to some extent JNK inhibition. Furthermore, these transformed cells were sensitized to apoptosis using paclitaxel and quercetin, but not other therapies. For the first time, we have demonstrated that EpCAM mutations can cooperate with H-Ras and promote EMT. Collectively, our results highlight future therapeutic opportunities in EpCAM and Ras mutated cancers.
Field-deployable multiplex detection method of SARS-CoV-2 and influenza virus using loop-mediated isothermal amplification and DNA chromatography
Authors: Hayashida Kyoko , Garcia Alejandro , Moonga Lavel Chinyama , Sugi Tatsuki , Takuya Kodera , Kawase Mitsuo , Kodama Fumihiro , Nagasaka Atsushi , Ishiguro Nobuhisa , Takada Ayato , Kajihara Masahiro , Nao Naganori , Shingai Masashi , Kida Hiroshi , Suzuki Yasuhiko , Hall William W. , Sawa Hirofumi , Yamagishi Junya
Published: May 2023

A novel multiplex loop-mediated isothermal amplification (LAMP) method combined with DNA chromatography was developed for the simultaneous detection of three important respiratory disease-causing viruses: severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), influenza A virus, and influenza B virus. Amplification was performed at a constant temperature, and a positive result was confirmed by a visible colored band. An in-house drying protocol with trehalose was used to prepare the dried format multiplex LAMP test. Using this dried multiplex LAMP test, the analytical sensitivity was determined to be 100 copies for each viral target and 100–1000 copies for the simultaneous detection of mixed targets. The multiplex LAMP system was validated using clinical COVID-19 specimens and compared with the real-time qRT-PCR method as a reference test. The determined sensitivity of the multiplex LAMP system for SARS-CoV-2 was 71% (95% CI: 0.62–0.79) for cycle threshold (Ct) ≤ 35 samples and 61% (95% CI: 0.53–0.69) for Ct ≤40 samples. The specificity was 99% (95%CI: 0.92–1.00) for Ct ≤35 samples and 100% (95%CI: 0.92–1.00) for the Ct ≤40 samples. The developed simple, rapid, low-cost, and laboratory-free multiplex LAMP system for the two major important respiratory viral diseases, COVID-19 and influenza, is a promising field-deployable diagnosis tool for the possible future ‘twindemic, ‘ especially in resource-limited settings.
Neurociências e Saúde Mental: Da Essência ao Contexto
Authors: Macedo António Ferreira de
Published: May 2023

Vivemos numa época em que já poucos mistérios persistem, mas talvez dois ainda suscitem o nosso fascínio e interesse em transcender as fronteiras do conhecimento que limitam a sua compreensão. Um é o macrocosmo dos corpos celestes do universo e do espaço infinitamente grande. O outro é o microscomo do nosso cérebro, contido na nossa cabeça, mas que também encerra galáxias de complexidade no intrincado funcionamento molecular das suas células e no pulsar elétrico dos seus neurónios. Este órgão que é o ator e autor de todos os nossos pensamentos, emoções, ações, sonhos e planos está tão perto, afinal todos temos um, mas tão longe do nosso completo entendimento. Por isso, o cérebro é o protagonista deste livro que nos convida e desafia para uma digressão conceptual que não tem ponto de partida, nem de chegada, antes constitui um percurso polissémico, que suscita mais questões do que respostas.
Models for assessing crisis dynamics in disparities of Ukraine’s regional economy to ensure the economic security of regions
Authors: Shevchenko Olga , Varnalii Zakharii , Kharlamova Ganna , Kuzmynchuk Nataliia
Published: May 2023

The increase in the unevenness of indicators of regional socio-economic development in Ukraine is causing changes in regional economic security, in addition to the deterioration of national welfare. Therefore, there is a need to develop new theoretical and practical approaches for assessing such disparities and forecasting their dynamics. In this article, a toolkit for modelling crises and catastrophes in disparities of regional development is presented, using the example of Ukraine. The purpose of this study is to create models that assess the crisis dynamics in regional disparities in Ukraine, in order to develop tools for ensuring economic security in the region. To achieve this purpose, the following tasks have been identified: to evaluate convergent-divergent processes and the long-term interaction of regional disparity indicators; to simulate possible crises and catastrophes in various spheres of socio-economic development of regions according to the levels of their disparities; and to demonstrate the mutual dependence between disparities of the regions and levels of their economic security. The result of the crisis dynamic assessment is a set of predictive models of possible catastrophes that may occur in Ukraine's regions. This allows for obtaining reliable results for the qualitative analysis of stability factors of disparities in the socio-economic system, accounting for different time intervals that determine the peculiarities of the country's development. The array of constructed models is an effective tool for researching crisis processes in the dynamics of disparity indicators, as they allow for identifying and more thoroughly investigating non-linear cyclical processes in regional economic development, as well as predicting changes in levels of economic security. Such a toolkit allows for the development of a strategy for balanced regional and country development, and for ensuring regional economic security.
The impact of institutional quality on economic growth: Evidence from post-soviet countries
Authors: Gasimov ILKIN , Asgarzade Gadir , Jabiyev Farid
Published: May 2023

The paper investigates the long-run impact of the institutional environment on economic growth for the sample of post-Soviet countries in 1996-2021. Using the Autoregressive Distributive Lag Model, we found that a U-shaped link exists between institutional quality and economic growth. Regarding the institutional quality dimensions, a similar link was observed for four out of six factors (POLSTAB, GOVEFF, RULELAW, CONTCORR). In contrast, the other two dimensions (REGQUAL, VOACC) exhibited inverted U-shaped impact on the dependent variable. Moreover, findings provide insight into the impact of control variables such as inflation (INF), openness (OPE), and population growth rate (POPGROWTH) on economic growth. More precisely, openness was found to have positive impact on the dependent variable, while inflation and population growth rate both had negative effect on economic growth. Based on these results, the paper suggests some policy implications for post-Soviet countries in terms of achieving economic growth by improving the institutional quality environment.
Is flexibility a dual mechanism? Evidence from the Hungarian food industry
Authors: Yousuf Allam , Oláh Judit , Sarihasan Imran , Rauf Abdul , Felföldi Janos
Published: May 2023

There is a body of evidence that flexibility as a mechanism can help to increase a company’s performance when an unexpected situation occurs. The food industry is considered one of the best industries and the performance of food industry undertakings accounts for 2.2% of Hungarian GDP. Food companies make up the third-largest manufacturing sector in Hungary. This study aims, therefore, to investigate the impact of operational flexibility on the performance of the Hungarian food industry by considering environmental uncertainty as a moderator. The research is cross-sectional. A customized questionnaire was used to obtain primary data. The questionnaires were distributed to a purposive group of managers, and there were 301 valid replies for statistical analysis. The findings revealed that operational flexibility has a beneficial impact on company success, while uncertainties in supply and demand do not have an effect on this link.
Determinants of Indonesia’s shrimp commodity export
Authors: Wati Lina Asmara
Published: May 2023

For the last decade, Indonesia has exhibited enormous fishery potential, especially in shrimp commodities, in terms of quantity, export value, and annual production. In Indonesia, shrimp is the commodity with the highest number of transactions compared to other fishery commodities. This research on the factors of Indonesian shrimp exports can be used as a reference and provide more detailed information useful for the government and Indonesian shrimp exporters. Panel data regression analysis and the gravity model were used to obtain the best REM model using GLS. Research results indicated that the GDP per capita of the importing country, distance, and the population of the importing country significantly influenced the export value of Indonesian shrimp. At the same time, the exchange rate was an insignificant variable. Therefore, to increase Indonesia's shrimp export potential, the government and Indonesian shrimp exporters must consider to the importing country's GDP per capita and the selection of partner countries.
Asymmetric effects of inflation rate changes on the stock market index: The case of Indonesia
Authors: Sia Peck-Ching , Leong Choi-Meng , Puah Chin-Hong
Published: May 2023

Over the years, macroeconomic fundamentals and the stock market were found to have symmetrical relationship in numerous scientific investigations. These fundamentals provide crucial knowledge regarding stock price indices by providing forecasts for the future and information on the current status of the economy. This study employs a Nonlinear Autoregressive Distributed Lags (NARDL) model to fill in the research gap by estimating the asymmetric relationship between inflation and stock market from 1996 to 2020. The study suggests that inflation has a long-run and short-run asymmetric affect on the stock price, while both positive and negative inflation changes harm stock prices. As it reveals, the asymmetric impact of inflation on the stock market, this study can assist investors and businesses in making well-informed decisions that result in a more efficient allocation of resources, ultimately benefiting the economy. Additionally, policymakers can utilize these findings to design effective strategies for managing inflation, stabilizing prices, promoting economic growth, and ensuring financial market stability.
Short Leash: A Memoir of Dog Walking and Deliverance
Authors: Gary Janice
Published: May 2023

anice Gary never walked alone without a dog - a big dog. Once, she was an adventurer, a girl who ran off to California with big dreams and hopes of leaving her past behind. But after a brutal rape, her youthful bravado vanished, replaced by a crippling need for safety. When she rescues a gangly Lab-Rottweiler pup,Gary is sure she’s found her biggest protector yet. But after Barney is attacked by a vicious dog, he becomes a clone of his attacker, trying to kill any dog that comes near him. Walking with Barney is impossible. Yet walking without him is unthinkable. After years of being exiled by her terror and Barney’s defensiveness, Janice risks taking her dog to a park near the Chesapeake Bay. There, she begins the messy, lurching process of walking into her greatest fears. As the leash of the past unravels, Barney sheds the defensive behaviors that once shackled him and Gary steps out of the self-imposed isolation that held her captive for three decades. Beautifully written, Short Leash is much more than a “dog story” or a book about recovering from trauma. It is a moving tale of love and loss, the journey of a broken soul finding itsway toward wholeness.
The Nature of Social Humanistic Thought in Ancient China
Authors: Abdul Hay Omar
Published: May 2023

Geographical reality and diverse historical conditions left a significant impact on Chinese agricultural life since its beginning and throughout its later stages of growth. In light of it, intellectual structures were formed in ancient China over many centuries. Led by Confucianism and Daoism, various schools of ancient Chinese thoughts succeeded in forming intellectual foundations in social, humanistic and political dimensions. These thoughts came to express the achievements of Chinese humanistic development, which adheres to the customs, traditions, and virtuous family and community moral principles. Their effects are still evident today in modern Chinese humanistic thought.
The New Evolution of China’s Diplomacy with Arab States Under the Background of the Sino- U.S. Competition: Trends and Prospects
Authors: Chen Jie
Published: May 2023

The interaction between China and Arab countries has a long history. After entering the 21stcentury, China-Arab relations have ushered in many important stages. In July 2018, the two sides agreed to establish a strategic partnership, which has become a new historical beginning for China-Arab friendly cooperation. At the same time, Sino-US relations plummeted. The United States changed its strategic positioning towards China, strengthened its containment of China, and opened the era of Sino-U.S. strategic competition. Therefore, China-Arab relations will be in an important field of strategic competition between China and the United States, which will become an important variable affecting the development of China-Arab relations. Starting from the internal and external factors affecting China-Arab relations, this paper intends to further analyze the changes in China’s diplomatic style of becoming more active in participating in Arab affairs and diversifying the fields and modes of exchange between the two sides under the current background of great power competition, then clarify the unity of stage and long-term, response and initiative, context and totality, and theory and practice embodied in such changes. At present, China must not only recognize the strategic significance of Arab countries, but also correctly understand the strategic contraction of the United States in the Middle East, and further consolidate China-Arab relations, expand the increment of cooperation, and pay attention to each other’s core interests by strengthening the frequency of diplomacy between heads of state, strengthening the use of multilateral mechanisms, strengthening the docking of development strategies, strengthening the supply of public goods, and strengthening exchanges and mutual learning among civilizations.
Assessing patient experience of the tenets of osteopathic medicine
Authors: Davis Glenn E. , Hartwig Walter Carl , Riemer Richard B. , Char Chandra , McTighe Adam , Kremelberg David
Published: May 2023

Context

Previous studies document that both osteopathic physicians and third-party observers identify an approach to the patient that is consistent with the philosophy and tenets of osteopathic medicine, often without investigating whether patients identify or are satisfied with it. Osteopathic physicians and the medical education community understand the distinctiveness of an osteopathic approach to the patient. Understanding the outcomes of an osteopathic approach to patient care includes confirming whether patients experience the tenets of osteopathic medicine in physician visits and, if so, how it relates to their experience of physician empathy and satisfaction with the visit.

Objectives

The objectives of this study were to assess patient experience of the tenets of osteopathic medicine, physician empathy, and satisfaction with the visit and to compare the results for patients who saw DOs with those who saw MD physicians.

Methods

More than 2000 patients at four outpatient clinic facilities were surveyed after a clinical visit on 22 prompts regarding their experiences of physician behaviors, physician empathy, and their own satisfaction with the encounter. Adult patients who were treated by an osteopathic or allopathic physician for a nonemergency encounter and who were not pregnant were included in the analysis. Survey results for 1,330 patient–physician encounters were analyzed utilizing linear regression models comparing constructs representing patient experiences of the tenets of osteopathic medicine (Tenets), physician empathy (Physician Empathy), satisfaction (Satisfaction) with the encounter, as well as additional demographic and encounter variables.

Results

Approximately 23.8 % of patients approached during the study period completed a survey (n=2,793), and among those, 54.7 % of patients who consented to the study and who saw a physician provider (n=1,330/2,431) were included. Significant (p≤0.01), positive associations among patient experiences of Satisfaction with the visit and Physician Empathy were observed among those who saw both DO and MD physicians. Patients experienced the Tenets during encounters with both DO and MD physicians, but linear regression showed that their experience of the Tenets was significantly (p≤0.01) and positively explained by their experience of Physician Empathy (β=0.332, p=0.00, se=0.052) and Satisfaction with the visit (β=0.209, p=0.01, se=0.081) only when the physician was a DO.

Conclusions

Patients identified physician behaviors consistent with the Tenets and positively associated their experiences of Physician Empathy and Satisfaction with the visit regardless of physician training background. Patient experience of the Tenets significantly explained their experiences of Physician Empathy and Satisfaction after visits with a DO but not after visits with an MD.
Abundance and activity patterns of the endangered margay (Leopardus wiedii) in temperate forest remnants from the avocado landscape in Mexico
Authors: Monterrubio-Rico Tiberio C. , Gallardo-Téllez Eduardo G. , López-Ortiz Eduardo I. , Rodríguez-Correa Hernando , Charre-Medellín Juan F.
Published: May 2023

A survey was done to estimate margay abundance and activity in the context of high forest loss rates from avocado plantations for the temperate forest region of Michoacán state. Camera trap surveys were conducted from November 2015 to April 2020, recording 21 Margay detections of seven individuals. The capture rate ranged from 0.09 to 0.83 records/100 trap nights. The mean temporal density was 0.12 ind./km2, with an activity peak between 04:00 and 05:00 h. The Margay could serve as indicator species for restoration and forest conservation initiatives.
Arte, memória e saúde em territórios expandidos: tecendo redes de afetos ou arte pode não curar, mas sua ausência adoece
Authors: Amaral Lilian
Published: May 2023

A presente discussão propõe estabelecer um diálogo entre os campos da arte urbana contemporânea e saúde pública, em uma perspectiva histórica, a partir da presença dos CECCOS – Centros de Convivência e Cooperativa da cidade de São Paulo e o projeto de arte colaborativa TOQUE – instalação em processo | autoria compartilhada, considerando a realização da exposição processual realizada na Universidade de São Paulo, na galeria e espaço expositivo da Biblioteca Brasiliana, Fundação Guita e José Mindlin, em 2019. Olhares Transversos, espaço de memória, copesquisa e cocriação estabeleceram interlocuções entre os campos da criação poética como espaços de vida e potência existencial, ao mesmo tempo que reescreve a história da cultura urbana em suas interfaces interseccionais, interculturais e transdisciplinares.Palavras-chave: Arte urbana contemporânea, Saúde pública, CECCO - Centro de Convivência e Cooperativa, Toque, Arte colaborativa. Art, Memory and Health in Expanded Territories: Weaving Affect Networks or Art May Not Cure, But its Absence SickensAbstract: The present discussion proposes to establish a dialogue between the fields of contemporary urban art and public health, in a historical perspective, beginning with the existence of CECCOS – Center of Coexistence and Cooperative in the city of São Paulo, SP, Brazil and the collaborative art project TOQUE – installation in process | shared authorship, considering the realization of the processual exhibition held at the University of São Paulo, in the gallery and exhibition space at the Biblioteca Brasiliana, Fundação Guita and José Mindlin, in 2019. Transversals, memory space, coresearch and cocreation establish interlocutions between the areas of poetic creation as spaces of life and existential potency, while rewriting the history of urban culture in its intersectional, intercultural and transdisciplinary interfaces.Keywords: Urban contemporary art; Public health; CECCO – Community and Cooperative Center; Touch; Collaborative art.
Pesquisar, intervir, inventar com as Cidades
Authors: Gorczevski Deisimer , Albuquerque Aline Mourão de , Lima João Miguel Diógenes de Araújo
Published: May 2023

Nossas pesquisas propõem intervenções poéticas e políticas com as cidades que somos e com as quais nos inventamos em modos de viver e conviver — atentos às relações, singularidades e agenciamentos entre arte, cidade e vida —, em práticas que exercitam o pesquisar e intervir coletivo e transdisciplinar. Propomos pensar: como a arte pode ativar experiências estéticas com diferentes espaços-tempo das cidades e da universidade? Uma universidade que se movimenta entre as cidades e com as cidades. As artes e a universidade percorrem espaços do fazer cotidiano e da convivência, como ruas, praças, praias, becos, esquinas, casas, construções abandonadas e áreas verdes – espaços não convencionais das artes. Movimentar as artes e a universidade com o cotidiano demanda a invenção de modos de fazer-saber. Um dos desafios desta escrita é pensar acerca das especificidades de um laboratório de pesquisa em artes, de como ele nos solicita protocolos distintos de pesquisa, de pensamento, de visão e de invenção de mundo(s). Nesse breve artigo desejamos instigar os leitores a conhecerem o Laboratório Artes e Micropolíticas Urbanas (LAMUR), vinculado ao Programa de Pós- Graduação em Artes (PPGArtes), no Instituto de Cultura e Arte (ICA) da Universidade Federal do Ceará (UFC).Palavras-chave: Artes; micropolíticas; pesquisar com; invenção; cartografia.Abstract: Our investigations propose poetic and political interventions with the cities that we are, and with which we invent ways of living and living together – attentive to the relations, singularities and agencies between art, the city and life –, in practices that exercise collective and transdisciplinary modes of investigating and intervening. We question: how can art activate aesthetic experiences with the different time-spaces of cities and the university? A university that moves in between cities, and with cities. The arts and the university go through spaces of everyday life and coexistence, with the streets, squares, beaches, alleys, corners, houses, abandoned sites and green areas – non-conventional spaces of arts. To make the arts and the university move with everyday life demands inventing ways of making-knowing. One of the challenges of this writing is to think about the specif icities of a research laboratory in arts, how it requires different protocols of research, thinking, vision and invention of world(s). In this piece, we want to instigate readers to become acquainted with the Laboratory Arts and Urban Micropolitics (LAMUR), of the Arts Graduate Program (PPGArtes) at the Institute of Culture and Art (ICA) of the Federal University of Ceará (UFC). Keywords: Arts; micropolitics; investigate with; invention; cartography.
β2 nAChR Activation on VTA DA Neurons Is Sufficient for Nicotine Reinforcement in Rats
Authors: Walker Noah B. , Yan Yijin , Tapia Melissa A. , Tucker Brenton R. , Thomas Leanne N. , George Brianna E. , West Alyssa M. , Marotta Christopher B. , Lester Henry A. , Dougherty Dennis A. , Holleran Katherine M. , Jones Sara R. , Drenan Ryan M.
Published: May 2023

Mesolimbic nicotinic acetylcholine receptor (nAChRs) activation is necessary for nicotine reinforcement behavior, but it is unknown whether selective activation of nAChRs in the dopamine (DA) reward pathway is sufficient to support nicotine reinforcement. In this study, we tested the hypothesis that activation of β2-containing (β2*) nAChRs on VTA neurons is sufficient for intravenous nicotine self-administration (SA). We expressed β2 nAChR subunits with enhanced sensitivity to nicotine (referred to as β2Leu9′Ser) in the VTA of male Sprague Dawley (SD) rats, enabling very low concentrations of nicotine to selectively activate β2* nAChRs on transduced neurons. Rats expressing β2Leu9′Ser subunits acquired nicotine SA at 1.5 μg/kg/infusion, a dose too low to support acquisition in control rats. Saline substitution extinguished responding for 1.5 μg/kg/inf, verifying that this dose was reinforcing. β2Leu9′Ser nAChRs also supported acquisition at the typical training dose in rats (30 μg/kg/inf) and reducing the dose to 1.5 μg/kg/inf caused a significant increase in the rate of nicotine SA. Viral expression of β2Leu9′Ser subunits only in VTA DA neurons (via TH-Cre rats) also enabled acquisition of nicotine SA at 1.5 μg/kg/inf, and saline substitution significantly attenuated responding. Next, we examined electrically-evoked DA release in slices from β2Leu9′Ser rats with a history of nicotine SA. Single-pulse evoked DA release and DA uptake rate were reduced in β2Leu9′Ser NAc slices, but relative increases in DA following a train of stimuli were preserved. These results are the first to report that β2* nAChR activation on VTA neurons is sufficient for nicotine reinforcement in rats.
Analysis of Metacognitive Ability of Middle School Students in Science Learning by Using Reflection Blogs
Authors: Astutik Kartika Fitri , Wusqo Indah Urwatin
Published: May 2023

This study aims to analyze the metacognitive abilities of junior high school students through reflection blogs. This study uses the type of research One-Shot Case Study. The sampling technique in this study used a purposive sampling technique. Based on the questionnaire data, metacognitive ability was obtained with an average score of 155.5 or 78.94% in class VIII A and metacognitive ability with an average score of 153.15 or 55%. Similar to the results of the questionnaire, the data for writing reflection blogs on students showed a score of 66% in class VIII A and 63% in class VIII B. Based on these data, it was found that the metacognitive abilities of class VIII A and class VIII B students were in the high category.
Tidal Flood Susceptibility Mapping and Community Adaptation Assesment in Semarang Utara District
Authors: Jabbar Abdul , Fariz Trida Ridho , Putri Salma Dwi , Rahmawati Dwi , Prahmani Yonika Sindiana , Putri Rizda Amalia , Siregar Zepanya Gladis Tabita , Holeng Vera Angelina , Chasanah Aisya Nurul
Published: May 2023

North Semarang District is one of the areas that is often affected by tidal floods. This study will discuss flood distribution through tidal flood susceptibility mapping and identify adaptations. The first step is to carry out flood susceptibility mapping using DEMNAS data and sea tides. The second stage is to determine the key areas based on the tidal flood susceptibility map made. Key areas are useful for identifying forms of community adaptation to tidal floods through data collection in the form of observations and interviews. The mapping results show that the flood susceptibility area reaches 582.89 Ha or around 50% of the area of North Semarang District. The key areas with high susceptibility are settlements on Jalan Tambakrejo, Tanjungmas Village and it is known that the community responds by adapting patterns to changes in physical infrastructure, economic activity, and social development.
C4.5 Algorithm Optimization and Support Vector Machine by Applying Particle Swarm Optimization for Chronic Kidney Disease Diagnosis
Authors: Ariyanti Lisa , Alamsyah Alamsyah
Published: May 2023

Kidneys are one of the organs of the body that have a very important function in life. The main function of the kidneys is to excrete metabolic waste products. Chronic kidney disease is a result of the gradual loss of kidney function. Chronic kidney disease occurs when the kidneys are unable to maintain an internal environment consistent with life and the restoration of useless functions. Data mining is one of the fastest growing technologies in biomedical science and research. In the field of medicine, data mining can improve hospital information management and telemedicine development. In the first stage of data mining process, data processing is done with pre-processing by handling missing values ​​and data transformation. Then, the feature selection stage is carried out using the Particle Swarm Optimization algorithm to find the best attributes. Next, it is done by classifying the dataset. The algorithm used for classification is the C4.5 Algorithm and the Support Vector Machine. Both classifications are known as algorithms that have a fairly good level of accuracy. This study uses the chronic kidney disease dataset from the UCI Machine Learning Repository. The purpose of this study was to determine the level of accuracy of the comparison between the C4.5 Algorithm and the Support Vector Machine after applying the Particle Swarm Optimization algorithm. This research increases the accuracy by 100% for the C4.5 Algorithm and 98.75% for the Support Vector Machine by using 24 attributes and 1 class attribute.
Students' Mathematical Reasoning Ability Viewed from Self-Regulated Learning in the Missouri Mathematics Project Learning with Open-Ended Approach
Authors: Rahmatika Desfriyanti , Waluya Stevanus Budi
Published: May 2023

The mathematical reasoning ability of class VIII students of SMP Negeri 1 Kedungwuni is still relatively low. The purpose of this study is to analyze and describe students' mathematical reasoning abilities in the MMP learning model with an open-ended approach in terms of students' self-regulated learning. The method used is a mixed method with an explanatory sequential design strategy. The results showed that: (1) students' mathematical reasoning abilities in the MMP learning model with an open-ended approach achieved classical mastery; (2) there is a positive influence of students' self-regulated learning on students' mathematical reasoning abilities in the MMP learning model with an open-ended approach, namely 17.1%; (3) the average mathematical reasoning ability of students in the MMP learning model with an open-ended approach is better than the average mathematical reasoning ability of students in learning with a scientific approach; (4) there are differences in students' mathematical reasoning abilities in terms of students' self-regulated learning in the MMP learning model with an open-ended approach; (5) a description of students' mathematical reasoning abilities in terms of self-regulated learning in the MMP learning model with an open-ended approach, namely (a) students with high levels of self-regulated learning are able to fulfill all indicators of mathematical reasoning abilities well; (b) students with intermediate level self-regulated learning tend to be quite capable in all indicators of mathematical reasoning ability; (c) students with a low level of self-regulated learning tend to be able to present mathematical statements, but tend not to be able to fulfill the other three stages.
Mathematical Representation Ability in the Implementation of Ethno-Flipped Classroom Model Assisted by Interactive Media Based on Self-Efficacy
Authors: Sholihah Mar'atun , Isnarto Isnarto
Published: May 2023

This study aims to (1) determine the effectiveness of the Ethno-Flipped Classroom model assisted by interactive media on students' mathematical representation abilities, and (2) describe the mathematical representation abilities of students who have high, medium and low self-efficacy. This study was mixed-methods with sequential explanatory design. Retrieval of quantitative data using a mathematical representation ability test, while collecting qualitative data using self-efficacy questionnaires and interview guidelines. The population in this study were students of class VIII SMP N 2 Susukan, Banjarnegara Regency. The samples of this study were 25 students from the experimental class and 26 students from the control class. The results showed that (1) Ethno-Flipped Classroom assisted by interactive media was effective on mathematical representation abilities, (2) subjects with high self-efficacy were able to fulfill all indicators of mathematical representation abilities, namely verbal, symbolic and visual representations, (3) subjects with medium self-efficacy can fulfill indicators of verbal and symbolic representation, (4) subjects with low self-efficacy only fulfill indicators of verbal representation.
Students’ Mathematical Literacy Ability in Terms of Self Efficacy Through Problem Based Learning with PMRI Approach
Authors: Purnaningtyas Yasinta , Safa’atullah Muh. Fajar
Published: May 2023

This research aims to (1) find out whether mathematical literacy through Problem-Based Learning with PMRI Approach (PBL-PMRI) achieves Actual Completion Limit (ACL); (2) find out whether mathematical literacy through PBL-PMRI is classically complete; (3) to find out whether the average and proportion of mathematical literacy through PBL-PMRI is more than the average and proportion of mathematical literacy through PBL; (4) knowing whether students' self-efficacy influences mathematical literacy through PBL-PMRI; (5) describe mathematical literacy through PBL-PMRI based on students' self-efficacy. The research method used is a mixed method with a sequential explanatory design. Sampling in this research with cluster random sampling. While taking the subject with purposive sampling. The results of this research are: (1) mathematical literacy through PBL learning with the PMRI approach achieves Actual Completion Limit (ACL); (2) mathematical literacy through PBL-PMRI learning achieves classical mastery; (3) the average and proportion of students' mathematical literacy through PBL-PMRI are more than the average and proportion of mathematical literacy through PBL; (4) self-efficacy affects mathematical literacy through PBL-PMRI; (5) description of students' mathematical literacy with categories: (a) self-efficacy on fulfilling the four indicators; (b) self-efficacy is in the moderate of fulfilling 3 indicators and tends not to fulfill 1 indicator; (c) lower self-efficacy tends to fulfill 2 indicators, tends not to fulfill 1 indicator, and does not fulfill 1 indicator.
Possibilities of Anxiolytic Therapy in the Elimination of Stress Skin Manifestations: A Case Report
Authors: Sydorova Nataliia , Vereshchaka Volodymyr , Kuts Taras
Published: May 2023

The case of a 42-year-old female patient with pronounced itching and exanthema, mainly in the area of the trunk and lower limbs, is presented. Previously, the patient took antihistamines without effect, was treated for scabies, but the itching remained pronounced and led to rash and excoriations. From the anamnesis, it was found that the patient has a high level of stress. According to the Hospital Anxiety and Depression Scale, the anxiety of the patient reached 14 points, and depression 1 point. Functional (psychogenic) itching was suspected. Since the patient refused dermatologist consultation, therapy with the anxiolytic temgicoluril, topical antipruritic agents and nonpharmacological methods of treatment were recommended at the initial stage. The patient felt a significant relief of itching symptoms on the first day of anxiolytic usage, she withdrew topical antipruritic agents after 5 days of anxiolytic treatment, in 15 days she began to reduce the dose of temgicoluril, and at the end of the third week she stopped treatment with anxiolytic due to a significant positive effect. In three weeks, practically all elements of the rash, except for the largest wounds from scratching, disappeared. The peculiarity of the case is that functional itching was completely eliminated during anxiolytic therapy without other systemic medications, which emphasizes the importance of eliminating the component of stress and anxiety in the treatment of such patients.