bluuebunny/crossref_metadata_2025 huggingface dataset:
A prospective observational study of nurses performing minimally invasive tissue sampling of brain, liver, and lung tissues among deceased neonates and stillbirths in Ethiopia
Authors: Muhe Lulu Mussa , Paganelli Christina R. , Ayele Rahell Hailu , Desta Tigist , Mekasha Amha , Demtse Asrat , Awoke Tesfamichael , Elfu Teferi , Gebremariam Tewodros Yalew , Tamrat Dagnachew , Jiffar Amanuel Damie , Zenabu Aklilu Mekasha , Sori Moti , Parlberg Lindsay , Worku Alemayehu , Nigussie Assaye Kassie
Published: December 2023

Background

With a neonatal mortality rate of 33 per 1,000 live births in 2019, Ethiopia is striving to attain the Sustainable Development Goal target of 12 deaths per 1,000 live births by 2030. A better understanding of the major causes of neonatal mortality is needed to effectively design and implement interventions to achieve this goal. Minimally Invasive Tissue Sampling (MITS), an alternative to conventional autopsy, requires fewer resources and through task-shifting of sample collection from pathologists to nurses, has the potential to support the expansion of pathology-based post-mortem examination and improve mortality data. This paper evaluates the accuracy and adequacy of MITS performed by nurses at a tertiary and general hospital and in the home of the deceased.

Methods

Nurses in a tertiary and general hospital in Ethiopia were trained in MITS sample collection on neonatal deaths and stillbirths using standardized protocols. MITS sample collection was performed by both pathologists and nurses in the tertiary hospital and by nurses in the general hospital and home-setting. Agreement in the performance of MITS between pathologists and nurses was calculated for samples collected at the tertiary hospital. Samples collected by nurses in the general hospital and home-setting were evaluated for technical adequacy using preestablished criteria.

Results

One hundred thirty-nine MITS were done: 125 in hospitals and 14 inside homes. There was a perfect or almost perfect agreement between the pathologists and the nurses in the tertiary hospital using Gwet's agreement interpretation criteria. The adequacy of MITS samples collected by nurses in the general hospital was more than 72% when compared to the preset criteria. The adequacy of the MITS sampling yield ranged from 87% to 91% on liveborn neonatal deaths and 76% for the liver, right and left lungs and 55% for brain tissues in stillbirths.

Conclusions

This study demonstrated that task-shifting MITS sample collection to nurses can be achieved with comparable accuracy and adequacy as pathologists. Our study showed that with standardized training and supportive supervision MITS sample collection can be conducted by nurses in a tertiary, general hospital and, at the home of the deceased. Future studies should validate and expand on this work by evaluating task-shifting of MITS sample collection to nurses within community settings and with larger sample sizes.
Therapeutic applications of CRISPR/Cas9 mediated targeted gene editing in acute lymphoblastic leukemia: current perspectives, future challenges, and clinical implications
Authors: Assis Alan Jhones Barbosa , Santana Brunna Letícia de Oliveira , Gualberto Ana Cristina Moura , Pittella-Silva Fabio
Published: December 2023

Acute Lymphoblastic Leukemia (ALL) is the predominant hematological malignancy in pediatric populations, originating from B- or T-cell precursors within the bone marrow. The disease exhibits a high degree of heterogeneity, both at the molecular level and in terms of clinical presentation. A complex interplay between inherited and acquired genetic alterations contributes to disease pathogenesis, often resulting in the disruption of cellular functions integral to the leukemogenic process. The advent of CRISPR/Cas9 as a gene editing tool has revolutionized biological research, underscoring its potential to modify specific genomic loci implicated in cancer. Enhanced understanding of molecular alterations in ALL has facilitated significant advancements in therapeutic strategies. In this review, we scrutinize the application of CRISPR/Cas9 as a tool for identifying genetic targets to improve therapy, circumvent drug resistance, and facilitate CAR-T cell-based immunotherapy. Additionally, we discuss the challenges and future prospects of CRISPR/Cas9 applications in ALL.
Overview of molecular mechanisms of plant leaf development: a systematic review
Authors: Lv Zhuo , Zhao Wanqi , Kong Shuxin , Li Long , Lin Shuyan
Published: December 2023

Leaf growth initiates in the peripheral region of the meristem at the apex of the stem, eventually forming flat structures. Leaves are pivotal organs in plants, serving as the primary sites for photosynthesis, respiration, and transpiration. Their development is intricately governed by complex regulatory networks. Leaf development encompasses five processes: the leaf primordium initiation, the leaf polarity establishment, leaf size expansion, shaping of leaf, and leaf senescence. The leaf primordia starts from the side of the growth cone at the apex of the stem. Under the precise regulation of a series of genes, the leaf primordia establishes adaxial-abaxial axes, proximal-distal axes and medio-lateral axes polarity, guides the primordia cells to divide and differentiate in a specific direction, and finally develops into leaves of a certain shape and size. Leaf senescence is a kind of programmed cell death that occurs in plants, and as it is the last stage of leaf development. Each of these processes is meticulously coordinated through the intricate interplay among transcriptional regulatory factors, microRNAs, and plant hormones. This review is dedicated to examining the regulatory influences of major regulatory factors and plant hormones on these five developmental aspects of leaves.
Reactivity of observers’ facial skin blood flow depending on others’ facial expressions and blushing
Authors: Ishikawa Naoki , Asahina Masato , Umeda Satoshi
Published: December 2023

Facial skin blood flow (SkBF) has attracted attention as an autonomic indicator because it influences facial colour, which informs others of emotional states, and facial temperature related to social anxiety. Previous studies have examined the facial SkBF in people experiencing emotions; however, facial SkBF changes in the observers of emotions are poorly understood. Our study clarified facial SkBF changes related to observing others’ emotions by comparing the changes with other physiological indices. Thirty healthy participants (24 females; mean age: 22.17) observed six types of facial expressions (neutral, angry, and embarrassed expressions with and without facial blushing) and rated the emotional intensity of the other person. We measured their facial SkBF, finger SkBF, and cardiac RR interval as they made their observations. Facial SkBF generally decreased in relation to observing emotional faces (angry and embarrassed faces) and significantly decreased for angry expressions with blushing. None of the participants noticed blushing of facial stimuli. For the RR interval and finger SkBF, there was no variation depending on the observed facial expressions, although there was a general increase related to observation. These results indicated that facial SkBF is sensitive and reactive to emotional faces—especially angry faces with blushing— compared with other autonomic indices. The facial SkBF changes were not related to either RR interval changes or the intensity rating, suggesting that facial SkBF changes may be caused by vasoconstriction and have potential functions for our emotions. The decrease in facial SkBF may have a role in calming observers by preventing them from adopting the same emotional state as a person with intense anger. These findings clarify daily facial SkBF fluctuations and their relationship with our emotional processing in interpersonal situations.
The role of emotion in eating behavior and decisions
Authors: Ha Oh-Ryeong , Lim Seung-Lark
Published: December 2023

The present paper aims to provide the latest perspectives and future directions on the association between emotions and eating behavior. We discussed individual differences in the impact of negative emotions on eating, emotional eating as disinhibited eating decisions with heightened reward values of and sensitivity to palatable foods in response to negative emotions and social isolation, in addition to emotional eating as maladaptive coping strategies under negative emotion and stress, hedonic (pleasure-oriented) eating decisions mediated by the brain reward system, and self-controlled (health-oriented) eating decisions mediated by the brain control system. Perspectives on future directions were addressed, including the development of early eating phenotypes in infancy, shared neural mechanisms mediated by the ventromedial prefrontal cortex and the dorsolateral prefrontal cortex in emotion and eating decision regulation, possible roles of interoception incorporating hunger and satiety signals, gut microbiome, the insula and the orbitofrontal cortex, and emotional processing capacities in hedonic eating and weight gain.
Driving-related cognitive skills during antidepressant transcranial direct current stimulation: results in a subsample from the DepressionDC trial
Authors: Burkhardt Gerrit , Goerigk Stephan , Dechantsreiter Esther , Bulubas Lucia , Soldini Aldo , Zwanzger Peter , Diemer Julia , Padberg Frank , Brunnauer Alexander , Kumpf Ulrike
Published: December 2023

Therapeutic transcranial direct current stimulation (tDCS) is a well-tolerated neuromodulatory intervention. However, there are currently no data on its impact on driving skills. Therefore, we conducted a validated assessment of driving-related cognitive skills in participants of the DepressionDC trial, a multicenter, randomized-controlled trial investigating the antidepressant effects of 6-week prefrontal tDCS in patients with major depressive disorder (MDD). Twenty-one patients (12 women, active tDCS, n = 11, sham, n = 10) underwent an assessment of driving-related cognitive skills before and after the intervention. Using a Bayesian analysis approach, we found no group differences between active tDCS and sham tDCS in the pre-post treatment changes for visual perception (estimated median difference: 3.41 [−3.17, 10.55 89%-CI], BF01: 2.1), stress tolerance (estimated median difference: 0.77 [−2.40, 4.15 89%-CI], BF01: 1.6), and reaction time (estimated median difference: 2.06 [−12.33, 16.83 89%-CI], BF01: 6.5). Our results indicate that repeated sessions of a conventional bifrontal tDCS protocol do not negatively impact driving-related cognitive skills in patients with MDD.
Long-term detoxification of opioid use disorder with opium tincture assisted treatment
Authors: Omidvar Tehrani Sahar , Rezaei Ardani Amir , Akhlaghi Saeed , Shayesteh Zarrin Masood , Talaei Ali
Published: December 2023

Introduction

Retention in treatment, craving, and relapse rate are important indicators of the success rate in addiction maintenance therapy as they evaluate the effectiveness of the therapy and make necessary adjustments to the treatment plan. However, the rate of continuation in the treatment process and the rate of craving in patients with opioid use disorder undergoing maintenance treatment with opium tincture have not been studied. The present study aimed to investigate the rate of relapse, craving, and psychiatric disorders in patients with opioid use disorder undergoing treatment of gradual detoxification with opium tincture.

Methods

Ninety patients with opioid use disorder who underwent treatment with the gradual detoxification method using opium tincture in the form of Congress 60 for 11 months were enrolled in the study. The level of craving based on the Desire for Drug Questionnaire (DDQ) and patients’ self-report of drug use, the level of anxiety, depression, and sleep quality of patients were evaluated using the Beck Anxiety Inventory (BAI), Beck Depression Inventory (BDI), and Pittsburgh Sleep Quality Index (PSQI), respectively. Also, suicidal thoughts were assessed by Beck Scale for Suicidal Ideation and quality of life by the World Health Organization Quality of Life Questionnaire (WHOQOL-BREF).

Results

The study found that the treatment resulted in a relapse rate of 16.7% for relapse. We also found that all sub-scales of the desire for drug questionnaire (DDQ), depression, and anxiety were significantly lower at the end of the study compared to its beginning. Additionally, quality of life and sleep significantly increased at the end of the study. All areas of craving, anxiety, and depression significantly decreased in all follow-up sessions that took place 1, 5, and 11 months after the start of treatment. Moreover, sleep disorders were improved considerably at the end of the treatment.

Conclusion

The current study presented a low relapse rate of Iranian patients with opioid use disorder under structured treatment of gradual detoxification with opium tincture in a one-year follow-up period. Opium tincture under the Congress 60 protocol may help to control carving, decrease psychological disorders, improve quality of life, and consequently, lower relapse rate.
Methicillin resistant Staphylococcus aureus in the United Arab Emirates: a 12-year retrospective analysis of evolving trends
Authors: Thomsen Jens , Abdulrazzaq Najiba M. ,   The UAE AMR Surveillance Consortium, Menezes Godfred Antony , Ayoub Moubareck Carole , Everett Dean B. , Senok Abiola
Published: December 2023

Introduction

Methicillin resistant Staphylococcus aureus (MRSA) is a major contributor to the global burden of antimicrobial resistance (AMR). As MRSA continues to evolve, the need for continued surveillance to evaluate trends remains crucial. This study was carried out to assess MRSA trends in the United Arab Emirates (UAE) based on analysis of data from the national AMR surveillance program.

Methods

We carried out a 12-year (2010–2021) retrospective analysis of MRSA demographic and microbiological data collected as part of the UAE national AMR surveillance program. Participating centers from across the country routinely submit AMR surveillance data collected by trained personnel to the National AMR Surveillance Committee, where data is analyzed using a unified WHONET platform. Data on non-duplicate isolates associated with clinical infections were obtained and included in the analysis.

Results

A total of 29,414 non-duplicate MRSA isolates associated with clinical infections were reported between 2010 and 2021 (2010: n = 259; 2021: n = 4,996). MRSA represented 26.4% of all S. aureus (n = 111,623) isolates identified during the study period. In 2010, among the S. aureus isolates with reported oxacillin testing, 21.9% (n/N = 259/1,181) were identified as MRSA and this showed an increase to 33.5% (n/N = 4,996/14,925) in 2021. Although there was variation in the distribution of MRSA across the seven emirates of the country, most had an upward trend. Patient demographics reflected a male preponderance, with most being adults and from the outpatient setting. Isolates were mostly from skin and soft tissue infection specimens (72.5%; n/N = 21,335/29,414). Among the inpatients (N = 8,282), a total of 3,313 MRSA isolates were from specimens obtained ≤ 48 h after admission indicative of community acquired infection. Increasing resistance trends were observed for most antibiotics including ciprofloxacin, levofloxacin, moxifloxacin, erythromycin, gentamicin, trimethoprim-sulfamethoxazole, and quinupristin/dalfopristin. Low levels of resistance (0.0–0.8%) were sustained for linezolid except for 2015, 2016, and 2017 with 2.5, 2.6, and 2.9%, respectively. No confirmed vancomycin resistance was reported.

Conclusion

The increasing trend of MRSA isolates associated with clinical infections in the hospital and community settings is a concern. Continued monitoring including incorporation of genomic surveillance and infection control measures are recommended to stem the dissemination.
Anxiety prevalence and associated factors among frontline nurses following the COVID-19 pandemic: a large-scale cross-sectional study
Authors: Wang Shitao , Luo Guoshuai , Pan Dongsheng , Ding XiangQian , Yang Fei , Zhu Liping , Wang Shuo , Ma Xuelu
Published: December 2023

Introduction

Nurses are more likely to experience anxiety following the coronavirus 2019 epidemic. Anxiety could compromise nurses’ work efficiency and diminish their professional commitment. This study aims to investigate nurses’ anxiety prevalence and related factors following the pandemic in multiple hospitals across China.

Methods

An online survey was conducted from April 16 to July 3, 2023, targeting frontline nurses who had actively participated in China. Anxiety and depression symptoms were assessed using the Self-rating Anxiety Scale and the Self-rating Depression Scale (SDS), respectively. Multivariable logistic regression analysis was employed to identify factors linked with anxiety.

Results

A total of 2,210 frontline nurses participated in the study. Overall, 65.07% of participants displayed clinically significant anxiety symptoms. Multivariable logistic regression revealed that nurses living with their families [2.52(95% CI: 1.68–3.77)] and those with higher SDS scores [1.26(95% CI: 1.24–1.29)] faced an elevated risk of anxiety. Conversely, female nurses [0.02(95% CI: 0.00–0.90)] and those who had recovered from infection [0.05(95%CI: 0.07–0.18)] demonstrated lower rates of anxiety.

Discussion

This study highlights the association between SDS score, gender, virus infection, living arrangements and anxiety. Frontline nurses need to be provided with emotional support to prevent anxiety. These insights can guide interventions to protect the mental well-being of frontline nurses in the post-pandemic period.
Locally-selected cacao clones for improved yield: a case study in different production systems in a long-term trial
Authors: Armengot Laura , Picucci Marco , Milz Joachim , Hansen Jon Kehlet , Schneider Monika
Published: December 2023

Ageing plantations, poor genetic material, soil degradation, pests and diseases are, among other factors, limiting cacao production. To meet the increasing demand for cacao in the absence of productivity gains, forests are cleared and the use of external inputs is generalised, with severe negative impacts on biodiversity and GHG emissions. The use of improved plant genetic material should support a sustainable increase of production. In this study, we evaluate and compare the yield performance of four locally-selected clones with those of four widely-used international clones in South America and four full-sib families (crosses of the same international clones). The research was conducted in a long-term trial in Bolivia with different production systems, including monocultures and agroforestry systems under organic and conventional farming and a successional agroforestry system without external inputs. Their cacao yields and the factors determining productivity (pod index, flowering intensity, pod load, pod losses, aboveground biomass, harvesting period) were assessed during 5 years. The cacao trees grown in the two monocultures had higher yields than those in the agroforestry systems. This was the result of higher aboveground biomass, flowering intensity and pod load, and similar pod losses due to cherelle wilt and fungal diseases in the former when compared with the latter. No differences between conventional and organic management were observed. We did not identify any genotypes performing better in a specific production system. On average, the local clones had twofold and five times higher yields than the international ones and the full-sib families, respectively. This was related to their higher total pod load, bigger pods and higher yield efficiency, i.e., higher yield per unit of tree biomass. However, the local clones had less flowering intensity, more cherelle wilt and similar losses due to fungal diseases to those of the international clones. This study clearly shows the need to invest in selection and breeding programmes using locally-selected genetic material to increase cacao production and support renovation/rehabilitation plans. Breeding genetic material that is adapted to low light intensities is crucial to close the yield gap between monocultures and agroforestry systems, and to further promote the adoption of the latter.
Do county financial marketization reforms promote food total factor productivity growth?: a mechanistic analysis of the factors quality of land, labor, and capital
Authors: Liu Yang , Cui JunFu , Jiang Hui , Yan Hua
Published: December 2023

Improving food total factor productivity is a necessary way to break the double constraint of resources and environment, and promote the transformation of the food production system and the realization of the sustainable development goal of zero hunger. Based on the panel data of 729 counties in China from 2010 to 2019, this paper analyzes the effect of county financial marketization reform on food total factor productivity by using a two-way fixed effects model, focusing on the mechanism of the quality of factors such as land, labor and capital. The results show that county financial marketization reform promoted food total factor productivity growth by promoting technical progress, while technical efficiency did not play a significant role. Heterogeneity analysis shows that the effect of county financial marketization reform on grain total factor productivity is not significantly different in eastern and central China. There is a significant difference in the western region, where county financial market reform hindered the growth of grain total factor productivity. In terms of different functional areas of grain production, the facilitating effect is only played in the main grain production area, and the inhibiting effect is played in the main grain marketing area. Mechanistic analysis shows that the county financial marketing reform promoted the growth of food total factor productivity by improving the quality of labor and land, while the quality of agricultural capital has a masking effect. On this basis, it is necessary for the government to implement differentiated financial market-oriented reform strategies, and to guide and encourage county financial institutions to provide financial services to improve the quality of agricultural labor and farmland through tax incentives and loan interest subsidies.
Case report: A case of oviductal and uterine leiomyosarcoma in an 11-year-old dog
Authors: Kazmierczak Jillian , Sugai Nicole J. , Withowski Katie E. , Jonatan Abe , LeRoith Tanya , Cecere Julie T.
Published: December 2023

An 11-year-old, intact female Pomeranian dog was presented for evaluation due to an 18-h history of anorexia and lethargy. Abdominal ultrasound revealed a 3×3 cm mass of mixed echogenicity at the level of the left ovary. At laparotomy, a 5 mm mass was identified at the cranial region of the right uterine horn and a 3 cm round mass was visualized near the cranial aspect of the left uterine horn. Ovariohysterectomy was performed. A diagnosis of grade 1 oviductal and uterine leiomyosarcoma was made via histopathology for both masses. Oviductal leiomyosarcomas are rare and generally locally invasive similar to other soft tissue sarcomas but do not often metastasize. Uterine leiomyosarcomas are also uncommon but are one of the more common tumors affecting the female reproductive tract. This is the only known case report of oviductal leiomyosarcoma in the dog and the only report of uterine leiomyosarcoma in addition to oviductal leiomyosarcoma as well. This case illustrates the oviduct as an additional site that can be affected by leiomyosarcoma and demonstrates surgery as a treatment option for patients diagnosed with this condition.
First report of Strongylidae nematode from pilot whale (Globicephala macrorhynchus) by molecular analysis reveals the cosmopolitan distribution of the taxon
Authors: Junsiri Witchuta , Islam Sk Injamamul , Thiptara Auyarat , Jeenpun Autthaporn , Sangkhapaitoon Piyanan , Thongcham Khunanont , Phakphien Rattanakorn , Taweethavonsawat Piyanan
Published: December 2023

This study investigates the identification, genetic composition, and placement in the evolutionary tree of a particular nematode species found in a short-finned pilot whale in the Gulf of Thailand. To accomplish this, we utilized various methods, including microscopic observations, molecular techniques, and comparative analyses to better understand the characteristics of this parasite. Initially, we concentrated on studying the 18s rDNA sequence through nested PCR, resulting in a 774-bp product. After conducting a BLASTn analysis, we discovered that there were only a few sequences in the GeneBank that shared similarities with our nematode, particularly with Cyathostomum catinatum, although the percent identity was relatively low. To confirm the uniqueness of our sequence, we constructed a phylogenetic tree that demonstrated a distinct branch for our nematode, suggesting significant genetic differentiation from C. catinatum. Additionally, we sequenced a 399-bp section of the ITS2 gene using PCR, and the resulting data showed a close association with the Strongylidae family, specifically with Cylicocyclus insigne. This was further confirmed by BLASTn and CD-HIT-est results, which indicated a 99 and ~94% sequence homology with C. insigne, respectively. The ITS2 phylogenetic tree also supported the position of our isolated sequence within the Strongylidae family, clustering closely with C.insigne. Our findings shed light on the genetic connections, taxonomy, and evolutionary trends within the Strongylidae family, with a particular focus on the widespread nature of the Cylicocyclus genus. This study emphasizes the importance of utilizing molecular techniques and interdisciplinary approaches to gain insight into nematode diversity, evolution, and ecological dynamics in marine environments.
Delirium after Cardiac Surgery—A Narrative Review
Authors: Mattimore Daniel , Fischl Adrian , Christophides Alexa , Cuenca Jerry , Davidson Steven , Jin Zhaosheng , Bergese Sergio
Published: December 2023

Postoperative delirium (POD) after cardiac surgery is a well-known phenomenon which carries a higher risk of morbidity and mortality. Multiple patient-specific risk factors and pathophysiologic mechanisms have been identified and therapies have been proposed to mitigate risk of delirium development postoperatively. Notably, cardiac surgery frequently involves the use of an intraoperative cardiopulmonary bypass (CPB), which may contribute to the mechanisms responsible for POD. Despite our greater understanding of these causative factors, a substantial reduction in the incidence of POD remains high among cardiac surgical patients. Multiple therapeutic interventions have been implemented intraoperatively and postoperatively, many with conflicting results. This review article will highlight the incidence and impact of POD in cardiac surgical patients. It will describe some of the primary risk factors associated with POD, as well as anesthetic management and therapies postoperatively that may help to reduce delirium.
Atrial Fibrillation Ablation: Current Practice and Future Perspectives
Authors: Rottner Laura , Metzner Andreas
Published: December 2023

Catheter ablation to perform pulmonary vein isolation (PVI) is established as a mainstay in rhythm control of atrial fibrillation (AF). The aim of this review is to provide an overview of current practice and future perspectives in AF ablation. The main clinical benefit of AF ablation is the reduction of arrhythmia-related symptoms and improvement of quality of life. Catheter ablation of AF is recommended, in general, as a second-line therapy for patients with symptomatic paroxysmal or persistent AF, who have failed or are intolerant to pharmacological therapy. In selected patients with heart failure and reduced left-ventricular fraction, catheter ablation was proven to reduce all-cause mortality. Also, optimal management of comorbidities can reduce AF recurrence after AF ablation; therefore, multimodal risk assessment and therapy are mandatory. To date, the primary ablation tool in widespread use is still single-tip catheter radiofrequency (RF) based ablation. Additionally, balloon-based pulmonary vein isolation (PVI) has gained prominence, especially due to its user-friendly nature and established safety and efficacy profile. So far, the cryoballoon (CB) is the most studied single-shot device. CB-based PVI is characterized by high efficiency, convincing success rates, and a beneficial safety profile. Recently, CB-PVI as a first-line therapy for AF was shown to be superior to pharmacological treatment in terms of efficacy and was shown to reduce progression from paroxysmal to persistent AF. In this context, CB-based PVI gains more and more importance as a first-line treatment choice. Non-thermal energy sources, namely pulsed-field ablation (PFA), have garnered attention due to their cardioselectivity. Although initially applied via a basket-like ablation tool, recent developments allow for point-by-point ablation, particularly with the advent of a novel lattice tip catheter.
MARLIN Method: Enhancing Warehouse Resilience in Response to Disruptions
Authors: Colabianchi Silvia , Bernabei Margherita , Costantino Francesco , Romano Elpidio , Falegnami Andrea
Published: December 2023

Background: Endogenous and exogenous factors impact the operational characteristics of supply chains, affecting wholesale warehouses. The survival of a warehouse is often threatened by disruptive events that alter infrastructure and performance. The emergence of COVID-19 exemplified the need for adaptability in retail goods supply chains, emphasizing the necessity for responding to external shocks. Methods: The MARLIN (Method wArehouse ResiLience dIstruptioN) method, founded on theories and models of resilience engineering is introduced. MARLIN is a practical tool designed to identify key areas requiring intervention in response to disruptive events. An empirical test was conducted in an Italian warehouse. Results: The conducted test yielded tangible results, demonstrating the efficacy of the method. It successfully pinpointed areas necessitating intervention and identified Key Performance Indicators (KPIs) associated with disruptions. The study not only underscores the importance of data collection but also highlights the often-overlooked significance of warehouse management. Conclusions: The study establishes MARLIN as a valuable asset for stakeholders involved in disruption management. Its application has proven instrumental in recognizing areas of intervention and identifying KPIs related to disruptions. Ongoing research endeavors to broaden its applicability across diverse supply chain scenarios, aiming to enhance situational awareness and enable proactive risk assessment through what-if analysis.
The use of digital twin technology in the testing laboratories of forest machines
Authors:   St. Petersburg State Forestry Engineering University named after S. M. Kirov, Department of Mathematical Methods in Management, Churakov A. V. , Shushkov P. N., ,   St. Petersburg State Forestry Engineering University named after S. M. Kirov, Department of Mathematical Methods in Management, Dolzhikov I. S. ,   St. Petersburg State University of Architecture and Civil Engineering, Department of Industrial Safety, Mikhailova L. M. ,   Arctic State Agrotechnological University, Department of Technology and Equipment of the Forest Complex
Published: December 2023

One of the important environmental problems is the damage caused to the environment by the exhaust gases of internal combustion engines. They contain both non-toxic (nitrogen, carbon dioxide) and toxic (carbon monoxide, hydrocarbons, aldehydes, benzapyrene) chemicals that have a negative impact on both humans and nature. In addition to the daily operation of logging equipment, exhaust gases also occur during laboratory tests of internal combustion engines. In order to minimize the amount of exhaust gases during the study and testing of internal combustion engines of forest transport, the article proposes a variant of a digital twin, where by means of several tests of this sample, it will be possible to simulate other possible options, but with its electronic copy.
Anti-Russian Sanctions of the West as an Indicator of Destabilization of the World Economy
Authors:   Moscow State Institute of International Relations of the Ministry of Foreign Affairs of Russia (MGIMO University), Moscow, Tebekin A. V. ,   Lomonosov Moscow State University, Higher School of Cultural Policy and Management in the Humanitarian Sphere
Published: December 2023

The relevance of the presented research lies in the existence of a number of signs that clearly indicate that the global economic crisis that began in 2020 has not yet ended. The purpose of the presented research is to isolate anti-Russian sanctions of the collective West as an independent indicator of the destabilization of the world economic system, indicating its state of crisis. The scientific novelty of the results obtained lies in the fact that the presented work shows that the ongoing sanctions pressure on Russia, considered as a pilot project for a possible subsequent sanctions war against China (including a possible forceful clash between China and Taiwan), indicates the absence of a global economic development of such solutions that would demonstrate that the effect from the implementation of technologies related to the vector of one’s own creation (primarily due to the introduction of technologies of the new (sixth) technological order) is higher than the effect from the implementation of technologies related to the vector of weakening the positions of competitors (up to the outbreak of local wars), which gives reason to consider the intensity of Western anti-Russian sanctions as one of the significant indicators of the course of the global economic crisis. The practical significance of the results obtained in this study lies in the possibility of their use in assessing the processes of the current economic crisis and predicting the prospects for overcoming it.
Trade and Investment Cooperation Between Cambodia and Vietnam: Visible Progress and Hidden Issues
Authors:   Institute of China and Contemporary Asia of the Russian Academy of Sciences, Center for Vietnam and ASEAN Studies, Moscow, Burova E. S. , Mazyrin V. M. ,   Institute of China and Contemporary Asia of the Russian Academy of Sciences, Center for Vietnam and ASEAN Studies, Moscow; Lomonosov Moscow State University, Institute of Asian and African Countries
Published: December 2023

For a long time, geographically close countries were economically isolated from each other due to political factors, neglecting the obvious advantages of mutual cooperation. However, over the past two decades, the economic component has become the cornerstone of bilateral relations. Cooperation between Cambodia and Vietnam is developing dynamically and has a positive impact on the development of the economies of both countries. An increase in bilateral trade helps not only to meet the needs of the population and expand the sales market for products, but also to strengthen the export potential of Cambodia and Vietnam on the world market, what is more the latter at the expense of the former. There has also been an increase in intra-industry trade in recent years, indicating the beginning of vertical integration, taking into account identified comparative advantages. An important role is also played by Vietnam’s implementation of investment projects that fill empty niches, create the necessary infrastructure, make a significant contribution to socio-economic development, social security, stimulate the growth of budget revenues, and also create jobs in Cambodia. Vietnam has emerged as one of Cambodia’s most important trade and investment partners, increasing its presence in the neighboring market and playing an important role in the country’s development. Cambodia’s economy is booming, thanks in large part to developments in Vietnam’s (and, of course, China’s) sphere of influence. This confirms the theory of the benefits of flying “with a flock of geese.” Vietnam is historically and mentally inclined to help Cambodia through this influence, and apparently does not represent another model of relations. At the same time, there are also negative aspects of cooperation, such as inequality of trade and investment flows, Cambodia’s growing economic dependence on its neighbor, and weak integration. The study of the main aspects of Vietnam’s economic influence on Cambodia has become increasingly relevant in recent years. At the same time, the issue of Cambodian-Vietnamese trade and investment interaction has been poorly studied.
Main Trends in the Development of Economic Relations Between Japan and People’s Republic of China in the XXI Century
Authors:   Saint Petersburg State University, St. Petersburg, Tuaev K. S. , Nikolaev V. V. ,   North-West Institute of Management of the Russian Presidential Academy of National Economy and Public Administration, St. Petersburg
Published: December 2023

This article is devoted to the study of economic relations between Japan and the PRC in 2000–2020. The main indicators of bilateral trade, its structure, indicators of bilateral foreign direct investment between Japan and the PRC are presented and analyzed in the article. An assessment of the current state of Japanese-Chinese economic relations was given, factors affecting their development over the past 20 years were determined using the method of generalization of research materials, methods of comparative and correlation analysis of data, analytical method of information processing. The authors conclude that during the period under review, economic cooperation between Japan and China in trade and investments is expanding and strengthening, and their economic interdependence is increasing. The interest of Japanese corporations in carrying on business and opening branches in the PRC is indicated as the main factor of development. Political instability in bilateral Japanese-Chinese relations is indicated as a deterrent. The authors emphasize that in order to further increase the successful and stable development of economic partnership, the two states need to take specific steps for the purpose of political rapprochement and finding a compromise on controversial issues.
Un nuevo escenario de las interacciones pedagógicas de calidad en las escuelas
Authors: Quispe Flores Eva Rocio , Vara Esquibel Lucia Isabel , Berrospi Ybarguen Santiago Daniel
Published: December 2023

Las interacciones pedagógicas se refieren a la relación que se origina entre los docentes y estudiantes en las aulas u otro espacio del ámbito escolar; primordial proceso en el logro de las metas educativas. Se formuló como objetivo de esta investigación evaluar la influencia de los escenarios de las interacciones pedagógicas de calidad en las escuelas; el enfoque utilizado fue el cuantitativo, el método empleado fue el hipotético deductivo, el tipo de investigación fue básica con nivel descriptivo, explicativo causal y diseño no experimental. Con respecto al proceso para la recolección de datos se utilizó la técnica de la encuesta, el instrumento aplicado fueron dos cuestionarios, para procesar los resultados se utilizó la prueba de Nagelkerke, el cual mostró un valor 0,557, lo que evidencia que el desempeño docente influye en un 55,7% en las interacciones pedagógicas. Concluyendo que existe influencia en el desempeño docente en las interacciones pedagógicas.
Acompañamiento pedagógico: estrategia de mejora continua en educación inicial
Authors: Quispe Cuadros Emperatriz Gregoria , Gonzales Sánchez Aracelli del Carmen , Borjas Espíritu Emilio
Published: December 2023

En las escuelas, el desarrollo de la adecuada práctica profesional depende de múltiples factores, siendo uno de ellos la manera como son recibidas las recomendaciones para el beneficio de los estudiantes, en tal sentido se formuló como objetivo determinar relación del acompañamiento pedagógico y las estrategias de mejoras continua en la educación inicial. Se empleó la ruta cuantitativa con alcance correlacional como metodología, fue necesario construir dos instrumentos en escala de Likert los cuales fueron administrados a docentes en ejercicio de Educación Inicial, los resultados obtenidos evidenciaron una relación positiva de acuerdo a Rho Spearman de ,545 donde se demostró la relación entre ambas variables los que permitió determinar la importancia del acompañamiento pedagógico en los docentes dentro de la mejora continua.
Competencias digitales y desarrollo profesional en docentes de instituciones educativas públicas de Puno
Authors: Menacho Vargas Isabel , Trujillo Medrano Betty , Vásquez Ramos Segundo Pío , Quispe Salazar Marcelino Abundio , Acero Apaza Inses Miryam
Published: December 2023

La realidad actual de la educación peruana, evidencia un déficit en las instituciones en cuanto al proceso de enseñanza a causas de las restricciones que ha generado el COVID-19. Los docentes provenientes de zonas rurales presentan limitadas competencias digitales siendo esto el principal obstáculo. Debido a esta situación se presenta como objetivo de estudio determinar la relación entre las competencias digitales y el desarrollo profesional en docentes de las Instituciones Educativas Públicas. El estudio contó con enfoque cuantitativo, tipo básico, y diseño no experimental correlacional transversal. La población estuvo constituida por 85 docentes, y la muestra fue censal, la técnica empleada fue la encuesta y como instrumento se apoyó en el cuestionario. Los resultados evidencian una correlación positiva y significativa entre variables competencias digitales y desarrollo profesional, debido a que el coeficiente de correlación fue 0.585 y el p-valor 0.000 menor a 0.05, por lo cual se rechaza la hipótesis nula. Se concluye que existe una relación positiva y baja entre la variable competencias digitales y la dimensión planificación.
PEMBERDAYAAN LARVA (Maggot black soldier fly) DALAM MENGOLAH SAMPAH ORGANIK DI DAERAH RW 12 & RW 04 KELURAHAN CITEUREUP CIMAHI UTARA
Authors: Kurniati Iis , Dermawan Asep , Marliana Nina
Published: December 2023

Sampah merupakan masalah serius dan belum dimanfaatkan secara maksimal. Oleh karena itu, perlu dicarikan solusi agar sampah organik dapat diminimalisir serta menjadi lebih bernilai guna. Salah satu upaya yang bisa diterapkan di Daerah Rw 12 dan Rw 04 Desa Citeureup Cimahi Utara adalah dengan biokonversi menggunakan larva (Maggot black soldier fly). Larva BSF dengan kemampuannya sebagai pendegradasi sampah organik dimanfaatkan untuk mengkonversi materi organik sehingga memiliki potensi ekonomi. Sampah adalah sisa buangan dari suatu produk atau barang yang sudah tidak digunakan lagi, tetapi masih dapat di daur ulang menjadi barang yang bernilai. Sedangkan sampah organik adalah sampah yang berasal dari sisa mahkluk hidup yang mudah terurai secara alami tanpa proses campur tangan manusia untuk dapat terurai. Sampah organik bisa dikatakan sebagai sampah ramah lingkungan bahkan sampah bisa diolah kembali menjadi suatu yang bermanfaat bila dikelola dengan tepat. Tetapi sampah organik ini bila tidak dikelola dengan benar akan menimbulkan penyakit dan bau yang kurang sedap yang merupakan hasil dari pembusukan sampah organik yang cepat. Metode yang ditawarkan adalah transfer teknologi melalui penyuluhan, pelatihan dan pendampingan. Hasil kegiatan yang diharapkan dari penelitian ini adalah terjadinya peningkatan pengetahuan, keterampilan mitra tentang biokonversi sampah menggunakan larva BSF, serta diperoleh produk tambahan lainnya berupa sayuran organik yang diperoleh dari budidaya menggunakan sampah terurai yang biasa disebut bekas maggot (kasgot) dan lele organik yang diberi makan menggunakan maggot, sehingga kegiatan ini dapat membantu dalam usaha peningkatan gizi keluarga.
GERAKAN SAYANG LANSIA PADA MASA PANDEMIK COVID-19 DI DESA KERTAWANGI KABUPATEN BANDUNG BARAT
Authors: Kusniasih Susi , Lestari Febri Sri
Published: December 2023

Gerakan Sayang Lansia (GSL) merupakan satu program pemerintah untuk menyadarkan masyarakat akan peran lansia sehingga perlu menjaga keseimbangan kehidupan lansia. Ada tiga faktor yang dapat menjaga keseimbangan lansia dalam keluarga di era new normal ini, yakni faktor biologi dengan memenuhi kebutuhan fisik lansia dengan meningkatkan daya tahan tubuh, faktor psikologis dengan memenuhi kebutuhan mental lansia untuk disayangi dan dilindungi, serta faktor sosial budaya dengan memberikan sikap dan perilaku yang membuat lansia dihormati dalam keluarga. Target program kemitraan wilayah  ini adalah  kader, sedangkan luarannya adalah meningkatnya pengetahuan  dan keterampilan kader. Metode yang dilaksanakan  pelatihan kader  diawali pre test, pemberian materi tentang Gerakan Sayang Lansia, pendampingan kader dan diakhiri post test. Hasil akhir kader posyandu, khususnya di Desa Kertawangi, adanya peningkatan pengetahuan kader kesehatan mengenai kebutuhan fisik lansia dengan meningkatkan daya tahan tubuh melalui pendidikan kesehatan tentang kebutuhan gizi lansia senam lansia, teknik mencuci tangan yang baik pada lansia, dan penggunaan masker pada lansia; ketenangan psikologis lansia; kehidupan lansia dalam sosial budaya melalui penyuluhan tentang pentingnya sikap dan perilaku yang membuat lansia dihormati dalam keluarga.
PENERAPAN DETEKSI DINI KANKER SEVIKS DI TEMPAT HIBURAN KABUPATEN KARAWANG
Authors: Solihah Eneng , Sugiarsih Ugi , Warliana Warliana
Published: December 2023

DA Karaoke dan resto merupakan satu diantara banyaknya tempat hiburan yang berada di Kabupaten Karawang, yang berlokasi di puat kota. Hampir seluruh karyawati tempat hiburan DA adalah perempuan. Karyawati di tempat tersebut 65% berprofesi sebagai pemandu lagu (PL) pada karaoke, dengan gaya hidup hampir 58% adalah perokok aktif dan mengkonsumsi minuman keras serta 100% perokok pasif dan terkadang melakukan sex bebas atau dengan kata lain sebagai Wanita Pekerja Seks (WPS). WPS adalah kelompok wanita yang berisiko tinggi terkena kanker serviks. Resiko akan meningkat pada wanita yang melakukan hubungan sexual di usia kurang dari 16 tahun, riwayat persalinan lebih dari empat, mempunyai partner sexual lebih dari enam meningkatkan resiko 10 kali lipat, perokok aktif meningkatkan resiko dua setengah lebih besar dan perokok pasif meningkatkan satu koma empat. (Vet et all,2008). Data tersebut diatas menunjukkan bahwa adanya kerentanan terhadap kejadian kanker serviks yang disebabkan oleh prilaku seks bebas, yang dengan jelas bahwa sasaran melakukan seks dengan banyak pasangan (multi partner), perokok aktif dan mengkonsumsi minuman keras.