bluuebunny/crossref_metadata_2025 huggingface dataset:
The Grb2 splice variant, Grb3-3, is a negative regulator of RAS activation
Authors: Seiler Caroline , Stainthorp Amy K. , Ketchen Sophie , Jones Christopher M. , Marks Kate , Quirke Philip , Ladbury John E.
Published: September 2022

Activation of RAS is crucial in driving cellular outcomes including proliferation, differentiation, migration and apoptosis via the MAPK pathway. This is initiated on recruitment of Grb2, as part of a Grb2-Sos complex, to an up-regulated receptor tyrosine kinase (RTK), enabling subsequent interaction of Sos with the plasma membrane-localised RAS. Aberrant regulation at this convergence point for RTKs in MAPK signalling is a key driver of multiple cancers. Splicing of the GRB2 gene produces a deletion variant, Grb3-3, that is incapable of binding to RTKs. We show that, despite maintaining the ability to bind to Sos, the Grb3-3-Sos complex remains in the cytoplasm, unable to engage with RAS. Competition between Grb2 and Grb3-3 for binding to C-terminal proline-rich sequences on Sos modulates MAPK signalling. Additionally, we demonstrate that splicing is regulated by heterogenous nuclear riboproteins C1/C2, and that normal and malignant colon tissue show differential Grb3-3 expression.
A functional interaction between liprin-α1 and B56γ regulatory subunit of protein phosphatase 2A supports tumor cell motility
Authors: Ripamonti Marta , Lamarca Andrea , Davey Norman E. , Tonoli Diletta , Surini Sara , de Curtis Ivan
Published: September 2022

Scaffold liprin-α1 is required to assemble dynamic plasma membrane-associated platforms (PMAPs) at the front of migrating breast cancer cells, to promote protrusion and invasion. We show that the N-terminal region of liprin-α1 contains an LxxIxE motif interacting with B56 regulatory subunits of serine/threonine protein phosphatase 2A (PP2A). The specific interaction of B56γ with liprin-α1 requires an intact motif, since two point mutations strongly reduce the interaction. B56γ mediates the interaction of liprin-α1 with the heterotrimeric PP2A holoenzyme. Most B56γ protein is recovered in the cytosolic fraction of invasive MDA-MB-231 breast cancer cells, where B56γ is complexed with liprin-α1. While mutation of the short linear motif (SLiM) does not affect localization of liprin-α1 to PMAPs, localization of B56γ at these sites specifically requires liprin-α1. Silencing of B56γ or liprin-α1 inhibits to similar extent cell spreading on extracellular matrix, invasion, motility and lamellipodia dynamics in migrating MDA-MB-231 cells, suggesting that B56γ/PP2A is a novel component of the PMAPs machinery regulating tumor cell motility. In this direction, inhibition of cell spreading by silencing liprin-α1 is not rescued by expression of B56γ binding-defective liprin-α1 mutant. We propose that liprin-α1-mediated recruitment of PP2A via B56γ regulates cell motility by controlling protrusion in migrating MDA-MB-231 cells.
Fluoride contamination, consequences and removal techniques in water: a review
Authors: Ahmad Shaz , Singh Reena , Arfin Tanvir , Neeti Krishna
Published: September 2022

Fluoride contamination has created a drinking water crisis globally.
Structural elucidation and isomeric differentiation/quantitation of monophosphorylated phosphoinositides using gas-phase ion/ion reactions and dissociation kinetics
Authors: Fabijanczuk Kimberly C. , Chao Hsi-Chun , Fischer Joshua L. , McLuckey Scott A.
Published: September 2022

Monophosphorylated phosphoinositides doubly deprotonated ions are subjected to sequential gas-phase ion/ion reactions. By utilizing ion/ion reaction products and performing kinetic experiments, dissociation rates are retrieved.
Stress induced self-rollable smart-stent-based U-health platform for in-stent restenosis monitoring
Authors: Kim Dong-Su , Oyunbaatar Nomin-Erdene , Shanmugasundaram Arunkumar , Jeong Yun-Jin , Park Jongsung , Lee Dong-Weon
Published: September 2022

To date, several smart stents have been proposed to continuously detect biological cues, which is essential for tracking patients’ critical vital signs and therapy.
High-throughput and directed microparticle manipulation in complex-shaped maze chambers based on travelling surface acoustic waves
Authors: Weng Wanyu , Pan Hemin , Wang Yancheng
Published: September 2022

A novel traveling surface acoustic wave (TSAW)-based manipulation device that allows for automated and high-throughput maze-solving manipulation of microparticles inside complex round-shaped and square-shaped maze chambers.
Nitric acid concentration strongly influences low level uranium determination on PEDOT-PSS coated glassy carbon electrodes
Authors: Agarwal Rahul , Dumpala Rama Mohana Rao , Sharma Manoj K.
Published: September 2022

Nitric acid concentration plays an important role in quantifying very low levels of uranium on PEDOT-PSS/GC electrodes. Its lower acidity (0.05 M) favours free UO22+ which complexes with PEDOT-PSS and thereby increases the detection limit.
Biochemical characterization of a cyanobactin arginine-N-prenylase from the autumnalamide biosynthetic pathway
Authors: Clemente Claudia , Johnson Nicholas , Ouyang Xiaodan , Popin Rafael V. , Dall'Angelo Sergio , Wahlsten Matti , Jokela Jouni , Colombano Alessandro , Nardone Brunello , Fewer David P. , Houssen Wael E.
Published: September 2022

Biochemical characterization of the prenyltransferase (AutF) from the autumnalamide pathway shows it targets the nitrogen of the guanidinium moiety in arginine and homoarginine.
Valence states of single Au atoms dictate the catalytic activity of Au1/CeO2(100)
Authors: Liu Rui , Qu Weiye , Hu Xiaolei , Chen Junxiao , Dong Yangyang , Xu Dongrun , Liu Jing , Ma Zhen , Tang Xingfu
Published: September 2022

The valence state of single Au atoms anchored on CeO2(100) is tuned and the catalytic activity of Au1/CeO2(100) in CO oxidation increases by one order of magnitude as the valence state of Au decreases from +0.93 to +0.27.
A highly selective and rapid solvatochromic material for amide solvent detection
Authors: Zhang Xinyang , Zhao Yunna , Wei Yi , Qiu Lei , Wang Wei , Wang Zhennan , Yang Hang , Chen Keqiang , Molokeev Maxim S. , Li Guogang
Published: September 2022

Cs2ZnBr4:Cu exerts a highly selective and rapid solvatochromic effect toward amide groups, which endow it with promising potential for application in amide detection.
Functions and fundamentals of porous molecular crystals sustained by labile bonds
Authors: Yamagishi Hiroshi
Published: September 2022

A few organic molecules have been found to form porous molecular crystals by simply stacking with each other via van der Waals forces or analogous weak interactions. This article reviews the fundamentals and functions of these crystals.
Incorporation of a boryl pendant as the trigger in a methacrylate polymer for backbone degradation
Authors: Makino Hiroshi , Nishikawa Tsuyoshi , Ouchi Makoto
Published: September 2022

Alkenylboronate was used as a comonomer for incorporation of the degradation trigger into the methacrylate polymers. The homolytic cleavage of the C–B bond using fluoride ion and an oxidant induced backbone degradation via β-scission.
Spontaneous formation of hierarchical structures in some polylactide/polysilsesquioxane blends
Authors: Herc Agata S. , Dudek Marta K. , Kaźmierski Sławomir , Bojda Joanna , Kaczorowski Witold , Januszewicz Bartłomiej , Kowalewska Anna
Published: September 2022

Evaporative crystallization of polylactide was modulated by functionalized ladder polysilsesquioxanes through conformational changes in the polyester backbone. Atypical spherulites spontaneously formed a hierarchical 3D superstructure.
Unusually high energy barriers for internal conversion in a {Ru(bpy)} chromophore
Authors: Cotic Agustina , Veys Koen , Escudero Daniel , Cadranel Alejandro
Published: September 2022

An unusually slow internal conversion (IC) process was demonstrated in a simple charge-transfer chromophore. Insights into the origin of the IC barrier are provided, which could be useful to prevent dissipation in solar energy conversion schemes.
Mechanics-based design of lithium-ion batteries: a perspective
Authors: Lu Bo , Yuan Yanan , Bao Yinhua , Zhao Yanfei , Song Yicheng , Zhang Junqian
Published: September 2022

The mechanics-based design of lithium-ion batteries during the preparation stage and the cycling stage is reviewed. The general problems currently being faced are summarized, followed by the outlook of possible solutions.
Tailoring the optoelectronic properties and dielectric profiles of few-layer S-doped MoO3 and O-doped MoS2 nanosheets: a first-principles study
Authors: Shahrokhi Masoud , Le Bahers Tangui , Raybaud Pascal
Published: September 2022

Opto-electronic properties and high frequency dielectric constant profiles of few layers van der Waals MoO3−xSx/MoS2−xOx heterostructures are simulated at DFT-HSE06 level for the purpose of photocatalytic applications.
Stretching-mode specificity in the Cl + CH3D(v1-I, v1-II, and v4 = 1; |jK〉) reactions: dependency on the initial |jK〉 selectivity
Authors: Mondal Sohidul , Pan Huilin , Liu Kopin
Published: September 2022

The beneficial impact of the initial rotational |jK〉-mode selection on the vibrational-specific reactivity is discussed.
A 3D/3D hetero-interpenetrated MOF with a novel (3,9)-c net and 6-c lcy net for the fluorescence detection of carbaryl
Authors: Shi Rong , Xu Ze-Ming , Cao Chen , Niu Zheng , Lang Jian-Ping
Published: September 2022

A 3D/3D hetero-interpenetrated MOF with a novel (3,9)-c topology exhibits a rare yellow-green fluorescence and the fluorescence quenching effect on carbaryl.
Enhanced Xe/Kr separation via the pore size confinement effect of a microporous thorium-based metal–organic framework
Authors: Mi Pinhong , Chen Lixi , Li Xiaoqi , Wang Xia , Li Guodong , Cheng Liwei , Lu Junhao , Zhang Hailong , Wang Yanlong , Wang Shuao
Published: September 2022

A thorium-based metal–organic framework with a suitable pore size for the uptake of Xe over Kr was developed for efficient Xe/Kr separation.
Understanding the tethered unhooking and rehooking of S2B in the reaction domain of FeMo-co, the active site of nitrogenase
Authors: Dance Ian
Published: September 2022

Energetically accessible reversible unhooking of S2B or S2BH from Fe2, as an intrinsic property of FeMo-co, needs to be considered in the formulation of mechanisms for the reactions of nitrogenase.
Analysis and prediction of anion- and temperature responsive behaviours of luminescent Ru(ii)-terpyridine complexes by using Boolean, fuzzy logic, artificial neural network and adapted neuro fuzzy inference models
Authors: Deb Sourav , Sahoo Anik , Mondal Priyam , Baitalik Sujoy
Published: September 2022

Anion- and temperature responsive behaviours of Ru(ii)-terpyridine complexes were analyzed through Boolean, fuzzy logic, ANN and ANFIS models.
FeCoS2 polyhedral spherical nanoparticle decorated nitrogen doped hollow carbon nanofibers as high-performance self-supporting anodes for K-ion storage
Authors: Xu Haoshan , Huang Shuhong , Yang Yang , Chen Jintao , Liang Lingxun , Zhang Jun , Li Ling , Zhao Xiaohui , Zhang Wenming
Published: September 2022

Application of 3D self-supported FeCoS2@N-HCNF nanocomposites as potassium ion battery anodes.
Retraction: Design, synthesis, and evaluation of a highly effective and safe perfluoro-alternative with a “weak site”: potassium 1,1,2,2,3,3,4,4-octafluoro-4-(perfluorobutoxy)butane-1-sulfonate
Authors: Guo Rui , Gao Yangguang , Liu Guoxing
Published: September 2022

Retraction of ‘Design, synthesis, and evaluation of a highly effective and safe perfluoro-alternative with a “weak site”: potassium 1,1,2,2,3,3,4,4-octafluoro-4-(perfluorobutoxy)butane-1-sulfonate’ by Rui Guo et al., Green Chem., 2022, 24, 1114–1119, https://doi.org/10.1039/D1GC04536A.
Hierarchical nanoporous Ge anodes for lithium-ion batteries via plasma-phase-fabricated Mg2Ge
Authors: Fan Zhen , Stevenson Siobhan C. , Mungall Alexander , Nishio Akira , Szczęsny Robert , Lin Yan-Gu , Chen Mark , Liu Wei-Ren , Okada Shigeto , Gregory Duncan H
Published: September 2022

Microwave-induced Mg plasma rapidly “deep reduces” GeO2 to Mg2Ge, a precursor to bespoke hierarchical nanoporous Ge, which acts as a high-performance anode in lithium-ion cells.
Oxidative degradation of sequence-defined peptoid oligomers
Authors: Schunk Hattie C. , Austin Mariah J. , Taha Bradley Z. , McClellan Matthew S. , Suggs Laura J. , Rosales Adrianne M.
Published: September 2022

Adaptable degradative responses to multiple biological stimuli are of great importance for biorecognition. Here, enzymatic and ROS degradability are tuned by monomer identity and sequence in a series of sequence-defined oligomers.
A bright future for proteomics of health and disease. Introduction to the US HUPO 2021 themed issue – proteomics from single cell to systems biology in health and disease
Authors: Pino Lindsay , Banarjee Reema , Basisty Nathan
Published: September 2022

Lindsay Pino, Reema Banarjee and Nathan Basisty introduce the Molecular Omics themed issue on proteomics from single cell to systems biology in health and disease.
Ag@Au bimetallic nanoparticles: an easy and highly reproducible synthetic approach for photocatalysis
Authors: Urzúa Esteban , Gonzalez-Torres Fernando , Beltrán Valentina , Barrias Pablo , Bonardd Sebastian , Ramírez A. M. R. , Ahumada Manuel
Published: September 2022

An Ag@Au bimetallic nanoparticle (BNP) formulation was developed in this work.
Recent advances in Al(iii)/In(iii)-based MOFs for the detection of pollutants
Authors: Li Letong , Zou Jiafeng , Han Yuting , Liao Zehao , Lu Pingfang , Nezamzadeh-Ejhieh Alireza , Liu Jianqiang , Peng Yanqiong
Published: September 2022

This paper focuses on summarizing the Al(iii)/In(iii)-MOFs for the detection of representative pollutants. The potential scope of development of the MOFs is briefly discussed to provide directions for in-depth exploration of the field.
An Eu3+-functionalized metal–organic framework (Eu@Zn-MOF) for the highly sensitive detection of rotenone in serum
Authors: Jin Yingmin , Xu Xin , Ma Wanpeng , Yan Bing
Published: September 2022

An Eu3+-functionalized hybrid material (Eu@Zn-MOF) is successfully prepared by the postmodification of Eu3+ ions on its free sulfonic groups. Eu@Zn-MOF can serve as a visual probe to specifically recognize and detect rotenone on the basis of fluorescence quenching effect.
Preparation, characterization and reactivity of trifluoromethoxy palladium(ii) complexes
Authors: Xu Songsong , Shao Yingbo , Zheng Hanliang , Leng Xuebing , Xue Xiao-Song , Shen Qilong
Published: September 2022

The preparation of the first nitrogen- or phosphine-ligated trifluoromethoxylated Pd(ii) complexes [(L)Pd(4-CF3Ph)(OCF3)] (L = TMEDA, 4-mepyridine or tBu-BrettPhos, BrettPhos, RuPhos and CPhos) was described.
Photocatalytic hydrogen generation from a methanol–water mixture in the presence of g-C3N4 and graphene/g-C3N4
Authors: Touati Wassila , Karmaoui Mohamed , Bekka Ahmed , Edelmannová Miroslava Filip , Furgeaud Clarisse , Chakib Alaoui , Allah Imene kadi , Figueiredo Bruno , Labrincha J. A. , Arenal Raul , Koci Kamila , Tobaldi David Maria
Published: September 2022

Synthesis and application of g-C3N4 and graphene/g-C3N4 in H2 production from water splitting, using different g-C3N4 precursors.
Visible-light-mediated decarboxylative (E)-alkenylation of aliphatic carboxylic acids with aryl styryl sulfones under metal-free conditions
Authors: Burlingham Sarah-Jayne , Guijarro David , Bosque Irene , Chinchilla Rafael , Gonzalez-Gomez Jose C.
Published: September 2022

A vitamin B2 derivative allows for the decarboxylative alkenylation of aryl styryl sulfones under visible light irradiation at room temperature to obtain olefins with excellent (E)-diastereoselectivity.
Switchable silver-ion complexation by triazolated calix[4]semitubes
Authors: Malakhova Maria , Gorbunov Alexander , Lentin Ivan , Kovalev Vladimir , Vatsouro Ivan
Published: September 2022

Triazolated calix[4]semitubes comprising two or three calixarene cores and crownether loop(s) form (hetero)multinuclear Ag+/K+ complexes or operate as molecular switches depending on the mutual arrangement of the receptor sites in the molecules.
LAMOST meets Gaia: The Galactic open clusters
Authors: Fu Xiaoting , Bragaglia Angela , Liu Chao , Zhang Huawei , Xu Yan , Wang Ke , Zhang Zhi-Yu , Zhong Jing , Chang Jiang , Li Lu , Chen Li , Chen Yang , Wang Fei , Gjergo Eda , Wang Chun , Yue Nannan , Zhang Xi
Published: September 2022

Open clusters (OCs) are born and evolve along the Milky Way (MW) plane. On them is imprinted the history of the Galactic disc, including its chemical and dynamical evolution. Chemical and dynamical properties of OCs can be derived from photometric, spectroscopic, and astrometric data of their member stars. Based on the photometric and astrometric data from the Gaia mission, the membership of stars in more than two thousand Galactic clusters has been identified in the literature. The chemical properties (e.g. metallicity) and kinematical properties (e.g. radial velocity), however, are still poorly known for many of these clusters. In synergy with the large spectroscopic survey LAMOST (data release 8) and Gaia (data release 2), we report a new comprehensive catalogue of 386 OCs. This catalogue has homogeneous parameter determinations of radial velocity, metallicity, and dynamical properties, such as orbit, eccentricity, angular momenta, total energy, and 3D Galactic velocity. These parameters enable the first radial velocity determination for 44 clusters, and the first spectroscopic [Fe/H] determination for 137 clusters. The metallicity distributions of the majority of clusters show falling trends in the parameter space of the Galactocentric radius, the total energy, and the Z component of angular momentum, except for two old groups that show flat tails in their own parameter planes. Cluster populations of ages younger and older than 500 Myr distribute diversely on the disc. The latter have a spatial consistency with the Galactic disc flare. The 3D spatial comparison between very young clusters (< 100 Myr) and nearby molecular clouds revealed a wide range of metallicity distribution along the Radcliffe gas cloud wave, indicating a possible inhomogeneous mixing or fast star formation along the wave. This catalogue will serve the community as a useful tool to trace the chemical and dynamical evolution of the MW.
BEYONDPLANCK
Authors: Paradiso S. , Colombo L. P. L. , Andersen K. J. , Aurlien R. , Banerji R. , Basyrov A. , Bersanelli M. , Bertocco S. , Brilenkov M. , Carbone M. , Eriksen H. K. , Eskilt J. R. , Foss M. K. , Franceschet C. , Fuskeland U. , Galeotta S. , Galloway M. , Gerakakis S. , Gjerløw E. , Hensley B. , Herman D. , Iacobellis M. , Ieronymaki M. , Ihle H. T. , Jewell J. B. , Karakci A. , Keihänen E. , Keskitalo R. , Maggio G. , Maino D. , Maris M. , Partridge B. , Reinecke M. , San M. , Suur-Uski A.-S. , Svalheim T. L. , Tavagnacco D. , Thommesen H. , Watts D. J. , Wehus I. K. , Zacchei A.
Published: September 2022

We present cosmological parameter constraints estimated using the Bayesian BEYONDPLANCK analysis framework. This method supports seamless end-to-end error propagation from raw time-ordered data onto final cosmological parameters. As a first demonstration of the method, we analyzed time-ordered Planck LFI observations, combined with selected external data (WMAP 33–61 GHz, Planck HFI DR4 353 and 857 GHz, and Haslam 408 MHz) in the form of pixelized maps that are used to break critical astrophysical degeneracies. Overall, all the results are generally in good agreement with previously reported values from Planck 2018 and WMAP, with the largest relative difference for any parameter amounting about 1σ when considering only temperature multipoles between 30 ≤ ℓ ≤ 600. In cases where there are differences, we note that the BEYONDPLANCK results are generally slightly closer to the high-ℓ HFI-dominated Planck 2018 results than previous analyses, suggesting slightly less tension between low and high multipoles. Using low-ℓ polarization information from LFI and WMAP, we find a best-fit value of τ = 0.066 ± 0.013, which is higher than the low value of τ = 0.052 ± 0.008 derived from Planck 2018 and slightly lower than the value of 0.069 ± 0.011 derived from the joint analysis of official LFI and WMAP products. Most importantly, however, we find that the uncertainty derived in the BEYONDPLANCK processing is about 30 % greater than when analyzing the official products, after taking into account the different sky coverage. We argue that this uncertainty is due to a marginalization over a more complete model of instrumental and astrophysical parameters, which results in more reliable and more rigorously defined uncertainties. We find that about 2000 Monte Carlo samples are required to achieve a robust convergence for a low-resolution cosmic microwave background (CMB) covariance matrix with 225 independent modes, and producing these samples takes about eight weeks on a modest computing cluster with 256 cores.
Hybrid assessment of acoustic radiation damping combining in-situ mobility measurements and the boundary element method
Authors: Baydoun Suhaib Koji , Roozen N.B. , Marburg Steffen
Published: September 2022

A hybrid experimental-numerical approach is proposed for assessing acoustic radiation damping – a major energy dissipating mechanism in lightweight structures. The vibrational behavior is characterized by distributed mobility measurements using laser Doppler vibrometry allowing to realistically capture the mechanical behavior of the structure under test. The experimentally obtained matrix of mobilities are coupled to a boundary element model to evaluate the radiated sound power numerically. Thereby, acoustic measurements and associated low frequency limitations are avoided, which results in two salient features of the proposed hybrid approach: modeling of diffuse incident acoustic fields and consideration of acoustic short-circuiting induced by slits and gaps. These features contribute to an accurate and excitation-dependent estimation of acoustic radiation damping in the low frequency range. The proposed hybrid approach is applied to flat and C-shaped aluminum sandwich panels mounted onto a tub-shaped foundation. The results are compared to those obtained by a previously reported numerical method.
Prix Boussinesq 2021 : « Détermination du module de cisaillement des sols sous faibles déformations à partir d’une sonde pressiométrique innovante »
Authors: Lopes dos Santos Alexandre
Published: September 2022

L’essai au pressiomètre Ménard est l’essai de référence pour la reconnaissance des sols en vue du dimensionnement des ouvrages géotechniques en France. Réalisé selon les normes en vigueur, il fournit un paramètre de déformation et de rupture du sol, respectivement le module pressiométrique Ménard et la pression limite pressiométrique. Ces paramètres peuvent être utilisés pour la conception de fondations superficielles et profondes sous chargements monotones, en s’appuyant sur des méthodes bien établies et comprises dans les normes d’application nationales françaises de l’Eurocode 7. Cependant, pour certaines structures telles que les fondations soumises à des charges cycliques répétées, les paramètres de calcul à prendre en compte correspondent à un niveau de déformation plus faible, qui ne peut être évalué à l’aide des procédures et des équipements pressiométriques usuels. Cet article présente le travail mené dans le cadre de la thèse de doctorat lauréate du Prix Boussinesq 2021 (Lopes A. 2020. Determination of soil shear modulus at low strain level using an innovative pressuremeter probe. Application to cyclic pile design. Thèse de doctorat). Cette thèse avait pour objectif le développement d’une nouvelle méthode de dimensionnement des fondations profondes sous charges axiales cycliques en utilisant l’essai pressiométrique. La recherche était inscrite dans le contexte du Projet National ARSCOP (nouvelles Approches de Reconnaissance des Sols et de la Conception des Ouvrages géotechniques avec le Pressiomètre). La démarche suivie permettant de surmonter les limitations de la pratique pressiométrique actuelle sera présentée, ainsi que la sonde innovante utilisée et les procédures d’essai et d’interprétation proposées. Les résultats obtenus, d’abord en condition d’essai contrôlée en chambre d’étalonnage au laboratoire, et puis en conditions réelles in situ, permettant de valider les procédures, sont présentés et discutés. Les applications à la pratique de l’ingénierie sont ensuite discutées.
An IoT-based Precision Agriculture Project for Education in Circuits and Systems
Authors: Rivet Francois , Ferre Guillaume , Raimond Ryan , Moreau Christophe , Gaury Corentin , Kerherve Eric
Published: September 2022

In this paper, we present how education can be involved in innovative CAS-based solutions and precision agriculture. We focus on a student project dedicated to plant growth monitoring using the Internet of Things (IoT). The objective was to make the students aware of the need for electronic solutions to sustain food production. They were proposed to design and deploy a network of connected devices using LoRa technology to monitor plants in our engineering school, ENSEIRB-MATMECA. We choose a deployment in LoRa technology in order to master the deployment of the network from the beginning to the end. Their work was divided into 3 parts: sensors, radiofrequency circuitry and data management.
Les enjeux industriels, économiques et académiques de la filière micro-électronique
Authors: Bonnaud Olivier
Published: September 2022

L’arrivée des objets connectés et de l’internet des choses (IoT) associé, ainsi que la perspective d’une nouvelle révolution industrielle (industrie 4.0.) conduisent à revoir l’ensemble de la formation des techniciens, ingénieurs, diplômés de masters, et des docteurs tout particulièrement du domaine de la microélectronique et des nanotechnologies qui sont au coeur de tous les outils et dispositifs mis en oeuvre. Si le développement apparait fulgurant et souvent très utile pour les applications sociétales, cette évolution amène de nouveaux défis qui sont liés à l’intégration des circuits et systèmes, à la pluridisciplinarité des dispositifs, au transport des flux de données et à la consommation d’énergie associée. Si l’industrie envisage de répondre à ces défis en recentrant au niveau français cette activité, il faut tout particulièrement revoir la conception, l’architecture et la technologie de ces objets, ce qui nécessite des compétences et du savoirfaire, et donc un vivier de formés préparé à relever ces nouveaux défis. Cette présentation aborde les enjeux et les limitations de l’évolution actuelle, propose un certain nombre d’approches du domaine de la microélectronique destinées à surmonter les défis et enfin détaille la stratégie actuelle du réseau national de formation à la microélectronique (CNFM) pour préparer les futures générations à contribuer à la pérennisation de la filière.
Apprendre l’apprentissage automatique : un retour d’expérience
Authors: Debs Noëlie , Peignier Sergio , Douarre Clément , Jourdan Théo , Rigotti Christophe , Frindel Carole
Published: September 2022

Dans cet article, nous présentons un retour d’expérience sur un module d’initiation à l’apprentissage automatique de 3 crédits ECTS que nous avons créé pour des élèves ingénieurs de l’INSA de Lyon. Nous présentons la structuration de ce module ainsi que les spécificités pédagogiques liées au faible nombre d’heures de face à face au regard de la complexité du sujet. Nous montrons des exemples de cas d’usage proposés aux étudiants et faisons état de leurs réactions. L’ensemble est complété par des liens bibliographiques vers les sites des outils numériques libres et références pédagogiques utilisées.
La Gamification dans le développement mobile et la domotique optimise l’apprentissage
Authors: Labiod Mohamed Aymen , El-Hillali Yassin , Vermeiren Laurent , Canonne Jean Charles
Published: September 2022

Les jeux informatiques font de plus en plus partie des activités quotidiennes des étudiants, il a également été démontré qu'ils soutiennent la motivation et l'apprentissage. C’est ainsi que la gamification a été pensé afin d’accomplir des tâches fastidieuses de manière agréable même si cela reste difficiles à mettre en oeuvre en classe. La gamification consiste à incorporer des éléments de jeux informatiques tels que des points, des classements et des badges dans des contextes non ludiques afin de tirer parti de la motivation fournie par un environnement de jeu. Dans ce travail, nous avons analysé l’utilisation de la gamification dans des TPs de domotique et de développement mobile. Notre étude démontre que l'intégration d'éléments de gamification telle que les points, les badges, les classements et les niveaux peut motiver les étudiants et soutenir leur réussite dans les environnements de sciences et technologies.
Le concept de système en thermodynamique
Authors: Nagels Maxime , Anakkar Abdelkader , Guelzim Abdelhalim
Published: September 2022

Une réflexion a semblé nécessaire sur les différentes définitions proposées dans la littérature pour la no-tion de système thermodynamique. A partir d’une analyse détaillée de 45 ouvrages du supérieur, nous avons parcouru la diversité des définitions proposées et montré les difficultés que cela engendre notamment sur l’appréhension des grandeurs énergie, matière et transferts d’énergie. Des exemples variés sont donnés pour étayer les propos. Quelques questions et perspectives sont proposées.
Attirer l’étudiant vers l’électronique à l’aide de la plastronique 3D et de la fabrication additive
Authors: Gerges Tony , Lombard Philippe , Allard Bruno , Cabrera Michel
Published: September 2022

L’enseignement de l’électronique se heurte à un manque d’appétence de la part des étudiants. Ouvrir le champ technologique vers la fabrication additive et la plastronique est de nature à solliciter de nouveau l’intérêt des étu-diants. Malheureusement il est délicat de donner un premier exemple pertinent qui confirme l’intérêt et mette les diffé-rents cours en perspective, car la plastronique balaie des connaissances allant des matériaux, à la chimie, la plasturgie, la conception mécanique 3D, etc. L’article présente un mini-projet sur la réalisation d’un dispositif plastronique à l’aide de la fabrication additive et de la métallisation autocatalytique, comme premier contact des étudiants avec les aspects tech-nologiques. Il s’agit de fabriquer une maquette de camion imprimée en 3D, qui embarque sur sa surface non plane un circuit électronique typique. Tout d’abord le schéma électronique et la conception mécanique sont réalisés et assemblés. L’objet est ensuite imprimé et les pistes sont métallisées. La maquette du camion est obtenue après le brasage des com-posants. Cette maquette vise à provoquer un questionnement de la part de l’étudiant et lui permettre de mieux position-ner le contenu des cours et travaux pratiques d’une formation spécialisée en plastronique.
Les Systèmes Embarqués Reconfigurables enseignés à des automaticiens
Authors: Vigne Benoît , Lapray Pierre-Jean
Published: September 2022

Dans le cadre de la formation d’ingénieurs automaticiens à l’ENSISA de Mulhouse, nous avons conçu un groupement d’unités d’enseignement portant sur la conception de systèmes numériques sur FPGA (Field Programmable Gate Array). L’offre comprend les bases de l’électronique numérique, la synthèse de systèmes combinatoires et séquentiels, et la description matérielle en langage VHDL. Il y a lieu de rapporter une expérience pédagogique, en ce qu’elle concerne des étudiants non électroniciens de formation. Nous détaillerons l’organisation des modules, les problématiques de pédagogie, et les possibles améliorations à apporter.
Dispositif électronique autonome en énergie utilisé pour la préservation des Hirondelles de fenêtre
Authors: Cresson Pierre-Yves , Gallet Eric , Favier Patrick
Published: September 2022

Dans le cadre des projets pédagogiques tutorés qui se déroulent chaque année, sur une semaine, au département GEII de l’IUT de Béthune (Université d'Artois), des groupes d'étudiants mélangeant 1ère année et 2ème année, sont constitués. Suivant un cahier des charges préalablement défini par un enseignant référent, ils doivent finaliser un projet, généralement dans le temps imparti. Ces projets réalisés à la jonction des semestres 1 et 2 et des semestres 3 et 4 encouragent les étudiants à approfondir leurs connaissances théoriques et expérimentales. Le projet que nous présentons dans cet article, nécessite des compétences en électricité, électronique, informatique et énergies renouvelables. Ce projet est motivant puisqu'il concerne la préservation d'espèces protégées. En effet, lorsque des Hirondelles de fenêtre qui sont des espèces protégées, habitent dans des bâtiments voués à la destruction, ceux-ci ne peuvent être détruits, tant que des Hirondelles de fenêtre y sont présentes. Le dispositif demandé aux étudiants doit permettre d'attirer les hirondelles à leur retour de migration, à un autre emplacement, une cabane en bois surélevée et équipée de 17 nids artificiels, afin qu’aucune ne soit présente dans les bâtiments lors du commencement des travaux de démolition.
3D diffeomorphic image registration with Cauchy–Riemann constraint and lower bounded deformation divergence
Authors: Han Huan , Wang Zhengping
Published: September 2022

In order to eliminate mesh folding in 3D image registration problem, we propose a 3D diffeomorphic image registration model with Cauchy–Riemann constraint and lower bounded deformation divergence. This model preserves the local shape and ensures no mesh folding. The existence of solution for the proposed model is proved. Furthermore, an alternating directional projection 3D image registration algorithm is presented to solve the proposed model. Moreover, numerical tests show that the proposed algorithm is competitive compared with the other four algorithms.
Une étude exploratoire des besoins de formation de formateurs novices en simulation
Authors: Magnin François , Delacour Chloé
Published: September 2022

Contexte : Au sein de la Haute École de santé de Fribourg (HEdS-FR), composante de la Haute École de Suisse occidentale, il n’est souvent pas possible former les formateurs novices en simulation dans les deux premières années suivant leur engagement. Le niveau de formation et d’expérience des nouveaux formateurs en soins infirmiers pour animer un débriefing post-simulation est très variable. L’enjeu est pourtant important, le débriefing post-simulation étant unanimement reconnu comme le moment où les apprentissages se réalisent et où se prépare leur transfert dans la pratique professionnelle/stage. But : Procéder à une étude exploratoire des besoins de formation des formateurs novices en simulation, en sollicitant leur sentiment de compétence, à partir d’une analyse de l’écart perçu entre leurs performances lors de la pratique du débriefing post-simulation en l’absence de formation spécifique et les performances souhaitées au regard des recommandations de bonnes pratiques en simulation en santé. Méthodes : Étude qualitative par entretiens individuels semi-dirigés de formateurs novices engagés à la HEdS-FR entre 2019 et 2020. Résultats : Cinq entretiens ont été réalisés. La comparaison des pratiques verbalisées lors des entretiens avec la grille Debriefing Assessment for Simulation in Healthcare (DASH) met en évidence des écarts au niveau du briefing, de l’analyse des performances des étudiants et des techniques d’animation et de questionnement. Les participants ont exprimé le désir d’être accompagné par des personnes expérimentées en débriefing et de disposer d’outils pour structurer le débriefing. Les critères qu’ils utilisent pour évaluer leurs débriefings et estimer leur sentiment de compétence sont proches de ceux de la grille DASH. Conclusion : La réponse aux besoins de formation des formateurs novices pourrait être un accompagnement spécifique par des experts, avec la grille DASH comme outil de référence pour les échanges, en plus d’être un outil d’autoévaluation.
Potentiale von und Empfehlungen zur Nutzung von GKV Routinedaten in
einer pandemischen Versorgungslage – Erfahrungen aus dem Projekt
egePan-Unimed des Netzwerk Universitätsmedizin (NUM)
Authors: Jacob Josephine , Walker Jochen , Swart Enno , Baum Fabian , Rößler Martin , Tesch Falko , Walther Felix , Wiegand Hauke Felix , Ihle Peter , Schmitt Jochen
Published: September 2022

In der COVID-19 Pandemie wurden zur Pandemiesteuerung und zur Evidenzgenerierung
für die Beantwortung drängender Fragen empirische
Datengrundlagen zu verschiedensten Fragestellungen benötigt, die mit
Hilfe von GKV Routinedaten generiert werden können. Im Rahmen des
Projektes egePan-Unimed des Netzwerk Universitätsmedizin (NUM) wurden
fünf pandemierelevante Fragestellungen mit GKV Routinedaten bearbeitet.
Untersucht wurden die Prävalenz und Relevanz von Risikofaktoren
für einen schweren COVID-19 Verlauf, die Hintergrundinzidenz der
Sinusvenenthrombose und Myokarditis, die Häufigkeit und
Ausprägung von Post COVID sowie die Versorgung von Personen mit
psychiatrischer Erkrankung. Auf Basis dieser Anwendungsfälle wurden
kontextspezifische Handlungsempfehlungen zur Nutzung von GKV Routinedaten
für zukünftige Pandemielagen abgeleitet. Diese umfassen
u. a. die Nutzung etablierter Kooperationspartnerschaften und
interdisziplinär zu besetzende Projektteams. Die datenschutzkonforme
Zusammenführung von Ergebnissen verschiedener Analysestellen wird durch
das (meta-analytische) Poolen aggregierter Routinedatenanalysen der
verschiedenen Datenhalter möglich. So können GKV Routinedaten
auch im Kontext der Pandemiesteuerung eine schnell verfügbare und valide
Datenquelle zur empirischen Begründung angemessener Public Health
Maßnahmen sein.
Comparative Pharmacokinetic Study of Two Pyrrolizidine Alkaloids Lasiocarpine and Heliotrine in Rats
Authors: Lin Feifei , Zhao Lijuan , Wang Yingying , Ye Yang , Liu Jia
Published: September 2022

Lasiocarpine (LAS) and heliotrine (HEL) are two different ester types of toxic pyrrolizidine alkaloids (PAs): open-chain diester and monoester. However, the pharmacokinetics of these two types of PAs in rats have not been reported. In the present study, two LC-MS/MS methods for determining LAS and HEL were established and validated. The methods exhibited good linearity, accuracy, and precision and were then applied to a comparative pharmacokinetic study. After intravenous administration to male rats at 1 mg/kg, the AUC0-t values of LAS and HEL were 336 ± 26 ng/mL × h and 170 ± 5 ng/mL × h. After oral administration at 10 mg/kg, the AUC0-t of LAS was much lower than that of HEL (18.2 ± 3.8 ng/mL × h vs. 396 ± 18 ng/mL × h), while the Cmax of LAS was lower than that of HEL (51.7 ± 22.5 ng/mL × h vs. 320 ± 26 ng/mL × h). The absolute oral bioavailability of LAS was 0.5%, which was significantly lower than that of HEL (23.3%). The results revealed that the pharmacokinetic behaviors of LAS differed from that of HEL.
Zur Wirkung der Diplomweiterbildung „Psychosoziale
Medizin“ (Psy1)
Authors: Wißgott Norbert
Published: September 2022

Die vorliegende Studie dient der Evaluation des Weiterbildungslehrganges
Psychosoziale Medizin (Psy1) der Österreichischen Ärztekammer
(ÖÄK).

Dieser freiwillig zu absolvierende Lehrgang ist das erste Modul der drei Module
umfassenden Psy-Diplom-Weiterbildung für Ärzt*innen in
Österreich. Der Weiterbildungslehrgang steigert die
Reflexionsfähigkeit, die Beziehungskompetenz und die Selbstsicherheit
der teilnehmenden Ärzt*innen. Daraus resultiert die
Förderung der Vertrauenswürdigkeit, der
Kommunikationsfähigkeit, der Selbstwirksamkeit, der Gesundheitskompetenz
und die Erhöhung der Effektivität ärztlicher
Behandlungsangebote. Hinzu kommt der Erwerb burnoutprophylaktischer Kompetenz.
Die Psy1-Diplomweiterbildung ist als qualitätssichernde Maßnahme
in Bezug auf die ärztliche Handlungskompetenz zu bewerten. Die
Ergebnisse dieser Studie ermutigen zu weiterführenden Untersuchungen, in
welchen auch die Weiterbildungsmodule Psy2 und Psy3 miteinbezogen werden
können.
Visible-Light-Mediated Organophotocatalyzed C(sp3)–H Activation and Intramolecular Cyclization
Authors: Sureshkumar Devarajulu , Ghosh Krishna G. , Pal Koustav , Das Debabrata , Chandu Palasetty
Published: September 2022

A metal-free approach for C(sp3)–H activation followed by an intramolecular Giese reaction to construct a wide range of cyclic ether scaffolds of various ring sizes under environmentally benign and straightforward conditions is reported. An easily prepared pyrylium salt is employed as an organophotocatalyst for this visible-light-driven, highly atom-economical (PMI = 64.34 g/g for a 0.2 mmol scale), cost-effective, and chemoselective transformation. The reported method has a broad functional-group tolerance, resulting in good-quality products. Furthermore, downstream functionalizations of a product and a gram-scale synthesis (PMI = 17.41 g/g for a 10 mmol scale) are demonstrated, highlighting our method’s advantages.
Cerebral Venous Sinus Stenting for the Treatment of Idiopathic Intracranial Hypertension in a Child
Authors: Rodrigues Leonardo Henrique da Silva , Aguiar Guilherme Brasileiro de , Torres Hélio Henrique Jorge , Xander Paulo Adolfo Wessel , Assunção Fernanda Boldrini , Scoppetta Thiago Luiz Pereira Donoso , Jory Mauricio , Veiga José Carlos Esteves , Conti Mario Luiz Marques
Published: September 2022

Idiopathic intracranial hypertension (IIH) is a disease characterized by an increase in the opening pressure of the cerebrospinal fluid (CSF) associated with symptoms of elevated intracranial pressure (ICP). The condition is more prevalent in women and typically managed clinically. Surgical treatment is reserved for select refractory cases. The well-established surgical procedures for the management of IIH are CSF shunting and fenestration of the optic nerve sheath. These procedures, however, are associated with high rates of complication and recurrence.

More recently, venous sinus angioplasty with stents has been employed in cases with documented narrowing of the sigmoid-transverse sinuses. This technique is associated with a significant reduction in the venous pressure gradient at the stenosis site, alleviating the symptoms of intracranial hypertension.

We report a case of a previously healthy 12-year-old patient who presented with 10-day history of headaches, blurring of vision, nausea and vomiting, which evolved with worsening of the visual acuity and papilledema. Imaging scans disclosed stenosis of the right transverse and sigmoid sinuses. The patient underwent stenting of the stenotic venous segments and showed good evolution, with significant clinical improvement within 24 hours of the procedure.
Intracranial Teratoma in Young Adult Female: Case Report
Authors: Marques Nathan Kulkys , Haag Karine , Buffara Leonardo Trindade , Steclan Chelin Auswaldt , Della André Possamai , Nones Diogo Pasquali , Junior Oscar Nelson Reimann , Peres Gabriel Hoher , Oliveira Arlindo Américo de , Júnior Amaurí Batista de Oliveira , Brito Leonard Rocha Fonseca de , Lang Michael Ricardo , Cabral Filipe Laurindo
Published: September 2022

Intracranial teratoma corresponds to a type of germ cell tumor (GCT) of the central nervous system which is characterized by the presence of tissues derived from the germinal layers, which may have hair and adipose tissue inside, for example. The literature on the subject is scarce, and the T2 magnetic resonance imaging (MRI) pattern commonly found is that of a heterogeneously hyperintense mass and, after contrast, teratoma presents heterogeneous enhancement. Therefore, the present case report aims to present atypical results of a GCT in a young adult woman. Data analysis and compilation were performed from medical records, as well as the neuroimaging study. Thus, the present case report demonstrates neuroimaging findings with homogeneous postcontrast enhancement in an adult patient, with an unusual age profile when compared with most of the studies published so far. This demonstrates that it is possible to have atypical neuroimaging findings for mature teratomas and that they can behave in a less aggressive way, not requiring adjuvant postoperative therapies.
Enfermedad cardiovascular aterosclerótica y sexualidad
Authors: Galvis-Acevedo Sebastián , Rivas-Escobar Daniela , Arias-Castillo Liliana , García-Perdomo Herney Andrés
Published: September 2022

La enfermedad cardiovascular aterosclerótica es la primera causa de muerte en todo el mundo, y la principal causa de años de vida perdidos por discapacidad (AVADs) en los adultos. Sus factores de riesgo son muy prevalentes en la población, y su ocurrencia se ha asociado con disfunción sexual tanto en hombres como en mujeres, debido a que comparten un mecanismo fisiopatológico similar en el caso de la disfunción eréctil en los hombres y potencialmente en la disfunción sexual femenina. Además, los trastornos mentales asociados (principalmente ansiedad y depresión) y los efectos adversos de los medicamentos antihipertensivos y antidepresivos también contribuyen a las disfunciones sexuales. Por otro lado, los inhibidores de la fosfodiesterasa 5 (iFDE5s) han demostrado seguridad y beneficios cardiovasculares en los hombres, y en las mujeres hay evidencia creciente de su utilidad en las disfunciones sexuales. En esta revisión, se presentan las implicaciones de la enfermedad cardiovascular aterosclerótica y su tratamiento en la vida sexual de hombres y mujeres, los efectos cardiovasculares de los tratamientos de las disfunciones sexuales, y la consejería a los pacientes.
Applications of Alternating Current/Alternating Potential Electro­lysis in Organic Synthesis
Authors: Hilt Gerhard , Jamshidi Mahdi , Fastie Cornelius
Published: September 2022

This review summarises the rarely used method of alternating current electrolysis for the synthesis of organic products. Different waveforms have been investigated which opens the possibility for further influence the outcome of the electrolysis by variation of the frequency as well as the highest peak current. In recent years alternating current electrolysis has been applied in increasingly more complex transformations. Especially the functionalisation of (hetero)arenes, functional group manipulation, metathesis reactions, and transition-metal-catalysed cross-coupling reactions were reported in recent years and the results of these and some other investigations are summarized in this review article.

1 Introduction

1.1 Waveforms

1.2 Objectives

1.3 Early Examples of the Optimisation of Alternating Current Electrolysis

2 Recent Applications of Alternating Current Electrolysis for Organic Synthesis

2.1 Substitution Reaction on Arenes

2.2 Nitrogen–Sulfur Bond Formation and Sulfur–Sulfur Bond Metathesis

2.3 Oxidation and Reduction

2.4 Cross-Coupling Reactions

2.5 Frequency Optimisation

3 Conclusion
Recent Advances in [3+2]-Cycloaddition-Enabled
Cascade Reactions: Application to
Synthesize Complex Organic Frameworks
Authors: Erande Rohan D. , Shivam Shivam. , Chavan Kailas A. , Chauhan Amar N. S.
Published: September 2022

Many natural products and biologically important complex organic scaffolds have convoluted structures around their core skeleton. Interestingly, with just changing the outskirts, the core reflects new and unique degrees of various physical and chemical properties. A very common but intriguing core is a five-membered ring horning heaps of organic molecules crafts. The power of [3+2] cycloaddition reactions to generate five-membered ring systems allocate chemists to envision synthetic procedures of wonder molecules and if it is facilitating a cascade sequence, then the end product will imbibe significant level of complexity having applications in medicinal and pharmaceutical fields. This Account highlights the broad interest in assembling recent advances in cascade reactions involving [3+2] cycloaddition as the power tool in order to conceive breakthrough organic architectures reported in the last ten years. We foresee that our comprehensive collection of astonishing [3+2] cycloaddition enabled cascades will provide valuable insights to polycyclic molecular construction and perseverant approach towards nonconventional synthetic procedures to the organic community.

1 Introduction

2 Synthesis of Oxindoles Skeleton

3 Synthesis of Oxazoles Skeleton

4 Synthesis of Oxadiazoles Skeleton

5 Synthesis of Nitrogen-Containing Heterocycles

6 Synthesis via Formal [3+2] Cycloaddition

7 Synthesis of Miscellaneous Scaffolds

8 Conclusion