bluuebunny/crossref_metadata_2025 huggingface dataset:
[RETRACTED] Hillstone Hemp CBD Gummies Reviews & Shark tank v1
Authors: not provided hillstonehempriews
Published: March 2022

[RETRACTED]

Hillstone Hemp CBD Gummies Reviews & Shark tank
Metalloproteinases as biochemical markers of pregnancy pathology
Authors: Grigorieva K. N. , Bitsadze V. O. , Khizroeva J. Kh. , Tretyakova M. V. , Blinov D. V. , Makatsariya N. A. , Tsibizova V. I. , Nakaidze I. A. , Gashimova N. R. , Grandone E. , Makatsariya A. D.
Published: March 2022

The success in modern biology has significantly enriched scientific understanding of the pathogenetic basis underlying some diseases, including obstetric and gynecological practice. Despite this, the etiology and pathogenesis of some conditions are not yet fully elucidated. One of the approaches is to study metalloproteinases during pregnancy, particularly concerning occurrence of formidable complication such as preeclampsia, which diagnostics and significance have been continuously revised. Preeclampsia is a disease that leads altered course of pregnancy, and sometimes even to maternal and/or fetal death. Currently, no specific treatment for preeclampsia has been proposed, but early prognosis is crucial for a more favorable maternal and fetal outcome. Given that metalloproteinase activity is able to influence trophoblast invasion and remodeling of spiral arteries, insights into such processes are of high importance.
«The father of blood coagulation»
Authors: Makatsariya N. A.
Published: March 2022

Here, the historical aspects of the life and scientific work of the physiologist Alexander Schmidt are considered. His contribution to the study of blood coagulation is described.
On the issue of suturing peripheral nerves and dorsal roots of the spinal cord
Authors: Tsypkin Ilya I.
Published: March 2022

To what extent the regeneration of peripheral nerves after injury is a question resolved in a positive sense, and there is only a dispute about the mechanism of this regenerationthe regeneration of the spinal cord and, in particular, the posterior roots, is still denied by the majority of those who have worked on this issue.

Studying the literature on the question that interests us, we see that the regeneration of the central nervous system in warm-blooded and cold-blooded animals is not the same. So Mller (1864) 102) after the removal of the entire tail in a newt and a lizard, saw a complete regeneration of the spinal cord and intervertebral nodes in the newly formed tail. Masius and Vanlair (according to Stroebe) (1869) saw in frogs the regeneration of fleshy and non-fleshy fibers and even ganglion cells after cutting a piece 2 mm long from the spinal cord. The possibility of regeneration of the spinal cord in reptiles and amphibians is also confirmed by Fraisse (1885) (according to Stroebe).
P. F. Kolchin. A case of tumor of the right frontal lobe of the brain. Surgery, № 160, Apr. 1910
Authors: Baklushinsky Ivan D.
Published: March 2022

For diff. Diagnosis is especially difficult in cases of tumors in the so-called indifferent places of the brain. Among such places is the right frontal lobe. The author describes a case of such a tumor; complicated by suppuration in the mastoid process.
Features of Melica virgata (Poaceae) seed germination in natural drought stress
Authors: Plyaskina Irina Nikolaevna , Bondarevich Evgeniy Aleksandrovich , Larina Nataliya Petrovna , Chistyakova Nataliya Sergeevna
Published: March 2022

The paper studies mechanisms of adaptation of the rare species Melica virgata Turcz. ex Trin for Eastern Transbaikalia to drought at the initial stages of ontogenesis. The species is listed in the Red Data Book of Trans-Baikal Territory and has the first conservation status category (Endangered). M. virgata occurs in special phytocenoses on the territory of Eastern Transbaikalia, being in such microclimatic conditions that correspond to its xeromesophytic nature. This cereal is characterized by seed reproduction. Researches of seed germination in conditions of physiological drought, caused by the presence of osmotic, have shown the ability of M. virgata seeds to germinate in a wide range of moisture availability, but growth processes with an increase in osmotic pressure are strongly suppressed. The ability to germinate in conditions of physiological drought may be associated with the exchange of free amino acids. The seeds of cereals were dominated by acidic amino acids and their amides, which are substrates for the formation of other amino acids, nucleotides, as well as after deamination reactions, carbohydrates and lipid components. The intensity of accumulation of free amino acids in water deficit can vary due to the use of these amino acids for the synthesis of substances with osmoregulatory properties. The rapid transition to growth processes in this cereal may be associated with the mobilization of prolamins and glutelins on the first day of germination.
Spiritual and moral education of believers by metropolitan Ioann (Snychev) in the Kuibyshev Diocese in 1965–1990
Authors: Verbovoy Vyacheslav Andreevich
Published: March 2022

The paper examines spiritual and moral education of believers in the Kuibyshev Diocese of the Russian Orthodox Church in 19651990 as one of the key areas of the episcopal activity of metropolitan Ioann (Snychev). The author studied such sources as reports of the authorized agent Council for Religious Affairs in the Kuibyshev Region, diary entries of metropolitan Ioann (Snychev) and people close to him, as well as the memories of believers. Metropolitan Ioann (Snychev) was not initially a talented preacher, but thanks to his studies and constant practice he was able to achieve success. The main tools of spiritual and moral education were sermons during worship services and personal communication with believers. In the conditions of preaching activity control by the office of the authorized agent for Religious Affairs, the bishop was forced to focus on moral issues. But despite the restrictions, metropolitan Ioann (Snychev) managed to conduct an active preaching activity. In private communication with believers, metropolitan Ioann (Snychev) unobtrusively taught Christian virtues. Metropolitan Ioanns (Snychev) high moral qualities helped him to gain love and respect of the believers. The result of the spiritual and moral education of believers by the bishop was the growth of his authority and the constant influx of parishioners to the Church.
Turkish political doctrine of «Neo-Ottomanism»: between symbolic and real content
Authors: Tovsultanov Rustam Alkhazurovich , Tovsultanova Malika Sharipovna , Galimova Lilia Nadipovna
Published: March 2022

The paper is devoted to the modern foreign policy doctrine of the Turkish Republic, usually labeled as Neo-Ottomanism. Turkeys leading politicians have declared their commitment to the Ottoman heritage. The latter is also actively promoted through television series and historical cinematography. The authors also note the internal political aspect of Neo-Ottomanism, aimed at softening interethnic relations and consolidating the country around the common historical heritage. However, based on the analysis of the real political practice of the Turkish leadership, the authors come to the conclusion about its predominantly symbolic (declarative-populist) purpose without denying the presence of Neo-Ottomanism in the Turkish political discourse. In their opinion, there is no reason to oppose the current political course of the Turkish leadership to the Kemalist heritage, the adherence to which, although not manifested as actively and vividly as the connection with the Ottoman tradition, is also inscribed in the populist discourse of the emergence of a new and great Turkey. R.T. Erdogan and his closest associates have a wide range of similar symbolic instruments, but in its real political practice, the Turkish leadership proceeds from the pragmatic interests of its country, which allows it to maintain and develop relations with various powers located at different geopolitical poles.
Principles and methods of civil identity formation in the modern conditions of the Russian State development
Authors: Buranok Aleksandr Olegovich , Selifontova Daria Yurievna
Published: March 2022

The paper examines the features of the society development in the Russian State interacting with the teaching civil identity feelings to the young generation. Researchers pay special attention to the issue of methods and ways of educating the young generation in modern conditions of society development, working out the possible results of mastering new tasks and courses set for teachers. The pedagogical tasks for teaching history and social studies have been determined: fostering a sense of civil identity among schoolchildren, studying traditions, cultures and values of the peoples of the Russian State; unification of the Russian society and interaction for the favorable development of the country in the future; private principles of upbringing schoolchildren are considered to achieve a wider level of patriotic feelings of schoolchildren. The problem of civil position, responsibility, social culture and socialization formation is considered as one of the main ones. In the course of studying theoretical material of both Russian and Soviet teachers, the basic principles of civil identity formation were revealed. A set of methods is formed on the basis of the principles of self-actualization, personalization and indivisibility of the processes of education and training. The analysis of theoretical and methodological literature showed a significant variety of pedagogical methods, techniques and technologies.
Desmoecological approach to ecological culture formation during professional training of pedagogical university students
Authors: Busygin Aleksandr Georgievich , Lizunova Elena Vladimirovna , Vershinina Lidiya Vasilievna , Bondareva Valeriya Vitalievna
Published: March 2022

Modern humanity lives in the era of the third millennium, in a period of a huge number of global environmental problems. The majority of environmental scientists attribute the low level of ecological culture of the individual and society as a whole to the main cause of the global environmental crisis. Currently, environmental security has become a dominant element of the national security doctrine. The term ecological culture itself considers an individual to be a subject of public relations and relations, introduces it into various types of activity interaction between society and nature, due to certain reasons that are associated with technology, exchange and consumption, with the attitude to property, as well as with certain norms, rules, laws, services, codes, etc. Analyzing the works of scientists and the experience of interaction between the environment and society, ecological culture includes a great potential, is the guiding force of the scientific and technological revolution. It is the teacher who plays a central function in the development of the ecological culture of youth. During the training sessions and during extracurricular hours, teachers should form a complex of scientific knowledge, worldviews, and ideas among students that the global environmental crisis, which may soon turn into an environmental catastrophe, poses a huge danger to all mankind. These phenomena can be prevented only with the help of targeted environmental protection activities. Environmental protection activities include a set of environmental knowledge, skills and abilities that students can master in the process of special education and training in an educational institution (school, vocational school, university). It is necessary to have a reliable level of elementary ecological concepts from an early age, and this suggests that the teacher must be sufficiently competent in this matter. He or she must have the skills to apply theoretical knowledge in practice and develop this skill among students. But as practice shows, in most cases, teachers themselves are not yet ready to implement this function. This is manifested in the fact that they do not have enough skills to adequately assess the state of the modern natural environment, to carry out environmental protection activities. This paper substantiates the effectiveness of the desmoecological approach aimed at ecological culture formation among pedagogical university students. The authors defined the content of the conceptual and terminological composition of the pedagogical categories ecological culture and desmoecological approach, developed a model of the integrative course Ecological culture of the future teacher.
MoReFa, Modular Regenerative Fashion
Authors:   , Hamilton Jill , Dion Genevieve , Nicholas Diana S.
Published: March 2022

The fashion industry contributes to environmental pollution due to excessive global landfill and carbon emissions. This thesis exploration is a speculative proposal for a new transparent and circular regenerative landfill-free future of apparel and textiles system, MoReFa (Modular Regenerative Fashion), challenging today's pervasive and static DMS (Design-Make-Sell) fashion model. MoReFa research intersects iterative modular garment pattern experimentation with regenerative components including dissolvability. 3D virtual simulation, 2D CAD, sketching, draping, shima seiki machine knitting, machine sewing, and other physical exploratory methods are used. Through research and reflective analysis, numerous positive system attributes emerged, such as regenerative, customizable, adaptable, scalable, and parametric fashion design options, algorithmic modeling and on-demand manufacturing possibilities, zero-waste production, biodegradable seaming, and natural sustainable modular elements, educational, entertainment, business, and craft opportunities and more. In conclusion, MoReFa's non-static holistic approach is human centric, environmentally friendly, and technology focused, and shifts DMS static fashion to a non-static transparent sustainable and circular regenerating system with positive consequences for a landfill free future of fashion solution. Key words: sustainable, circular, modular, regenerative, zero-waste, customizable, on-demand, adaptable, profitable, scalable, parametric, generative, fashion design, systems, 3D simulation, dissolvability, biodegradable, natural, educational, stylish, seasonless
Impact of the non-biodegradable plastics and role of microbes in biotic degradation
Authors: Biswas Soham , Das Arpita , Paul Joydeep , Bhadra Tuhin , Saha Abinit
Published: March 2022

Plastic is a group of elastic organic compounds whose definition has radically changed from being a large family of useful polymers to an indispensable part of life.  We might say we are residing in the “era of plasticene”. If we simply pause and look around, we would realize that a majority of things in our daily life comprise plastic polymers.  Currently, the international production of these polymers has spiked to around 300 million metric tons annually. Surprisingly about 50 percent of the products are discarded within a year of fabrication.  Once discarded ‘outside’ they end up ‘somewhere’ and start exerting their disruptive consequences.  Despite its enormous utility, it is now being increasingly known that these polymers are surely not without their downsides.  Several steps are taken and even more, are being investigated so the mayhem of plastic doesn't prove for a "no pilot in cockpit" situation. Here we have conducted a review work of the available literature on various biological entities that can utilize plastic while at the same time focusing our attempts to assemble information regarding the probable enzymes that do it.  We have also provided a report on the effect of different plastics on the ecosystem and the various management alternatives out there.
Методы обеспечения контроля и мониторинга на строительной площадке
Authors: Хандога Д.А. , Шнурникова Е.П. , Горбачев А.Ю.
Published: March 2022

Строительный сектор на сегодняшний день является наиболее развивающимся, даже при столь высоких объемах требуемых инвестиций. Малые и средние строительные компании, как правило, имеют возможность контроля строительных объектов за счет их малого количества и малых размеров самих объектов, чего нельзя сказать о более крупных организациях. Сотни и даже тысячи работников на строительных площадках являются большой опасностью при отсутствии должного контроля и мониторинга их деятельности. Целью данной статьи является рассмотрение и обоснование преимуществ использования комплексных систем контроля и мониторинга в строительстве и их благоприятное влияние на экономическую часть строительства, а также безопасность внутри объекта в целом.
Трансформация социальных ролей и домашний труд в советском обществе во вт. пол. XX в.
Authors: Синицына Е.В.
Published: March 2022

В статье исследован процесс социально-экономических трансформаций в Росси, где существенно изменились характеристики рынка труда, так же как и возможности людей различного возраста, пола и образования. Ассиметричное распределение мужчин и женщин на современном рынке труда и сегрегация профессий и различия в заработках являются существенным фактором сохранения за женщиной ее превалирующей роли в домашнем труде. Автор предлагает рассмотреть истоки сложившейся ситуации в формировании ролей трудящейся женщины с «двойной нагрузкой» в советском обществе, где только общественный труд оплачивался, а «экономика заботы» была невидимой частью ролевого набора советской женщины.
Complex of Pottery from the Basement (SK 2) from the Settlement Zavetnoe 5 at the South-Eastern Crimea
Authors: STOYANOV R.V.
Published: March 2022

The article presents an overview of the complex of pottery originating from the basement (CK2) from the settlement Zavetnoe 5 at the Eastern Crimea (fig. 1–2). The chronological boundaries of a series of transport amphorae fit within the interval from the 70s to the 2nd quarter of the 3rd cent. BC. (fig. 3–7). By the same period are dated groups of table uncovered (fig. 9–11), kitchen (fig. 12) and hand-made pottery (fig. 13). There are no specimens of the III cent. BC among the black glaze vessels from the complex (fig. 8). Such vessels were used in everyday life longer than other groups of pottery. The «delay» of the black-glaze pottery in this case, is not less than a quarter of a century. The exception in this case is only the lamps whose dating coincides with the group of transport amphorae (fig. 14). The obtained data are consistent with the stratigraphy of the complex, indicating that the filling of the basement, connected with the construction of one of the premises of the Hellenistic manor, was made in the 1st half of the 3rd cent. BC.
Enterprise Development Strategies in a Post-Industrial Society
Authors: Hurzhyi Nataliia , Kravchenko Alla , Kulinich Tetiana , Saienko Volodymyr , Chopko Nataliia , Skomorovskyi Andrii
Published: March 2022

This article examines the problems of forming a strategy for enterprise development in a post-industrial society. A characteristic feature of the contemporary post-industrial society is the constantly evolving new knowledge. Globalization processes and comprehensive digitalization affect the economic behavior of all economic entities and should be taken into account in the formation of strategies for their development. The driving force of progress in Contemporary conditions is closely related to the development of the abilities of a person, whose interests and needs are becoming one level higher. New transformation processes require enterprises to carry out balanced investment activities, research markets, competitors, suppliers, and conduct an effective marketing policy. Businesses need to implement planning taking into account the prospects for its development. The enterprise development strategy should be long-term and contain a flexible plan of action in the direction of innovation based on a detailed analysis of the internal and external environment of the enterprise, available resources and potential of the enterprise. For the successful functioning of the enterprise, the objective necessity is the assessment of its competitiveness, which is based on identifying the strengths and weaknesses of the enterprise for its maximum improvement and finding hidden opportunities for development. The implementation of the development strategy requires efficient investments and optimal use of available resources to achieve the planned results. In the process of creating a development strategy, companies need to take into account the various characteristics that affect it.
Specific Features of Investment in Human Capital in the Postmodern Society
Authors: Khachatrian Valentyna , Pavlyuk Tetiana , Pohrishchuk Halyna , Dobizha Nataliia , Bezchotnikova Svitlana , Osipova Larysa
Published: March 2022

The article deals with theoretical aspects of human capital, features of human capital, problems and prospects of human capital in modern conditions. Problems and challenges of ontology and functioning of human capital in postmodern society are outlined. The current state of investment in the reproduction of human capital and its development was assessed. One of the ways to increase human capital is to invest in people, their health and education. The article substantiates the role and importance of investments in human capital at the family level. The sharp increase in interest in the creative abilities of a person and in the ways of their formation and development confirm the obtained results. The international significance of the article lies in the objectification of the problems of human capital in developing countries (using the example of Ukraine), taking into account the global industrial, cultural and social context. In order to optimize human capital management on the verge of the postmodern and post-post era, these research results can help in the development of scientific, public and government programs and activities.
Development of Art Education as a Basis for Sustainable Development of Society
Authors: Malytska Olena , Patron Iryna , Chabanenko Nataliia , Shvets Olena , Polishchuk Anna , Martyniv Liubomyr
Published: March 2022

The article considers questions about the role and significance of art education in the context of ensuring sustainable development of society. The features of the development of art education in the postmodern era, its functions and specific features (individuality, creativity, understanding of a person as the highest value, etc.) are analyzed. The interdependence of arts education and sustainable development are characterized. The exceptional importance for ensuring sustainable development of an appropriately oriented and updated arts education was emphasized. In particular, it seems possible to ensure a change in stereotypes, ways of thinking and actions of people, the formation of appropriate motivation and public opinion in the context of applied nature through the influence of art. Ways to improve art education with the aim of ensuring sustainable development are proposed: integration of formal and non-formal art education, ensuring innovativeness, interdisciplinarity and multiculturalism of art education, creating an inclusive environment in higher educational institutions. We see prospects for further scientific research in the creation of a model for training specialists with certain properties and substantiation of the features of its implementation in real conditions of the educational process in higher education institutions of the artistic direction.
Badanie zderzenia kultur metodą biograficzną
Authors: Wysocki Artur
Published: March 2022

Artykuł prezentuje założenia teoretyczne i metodologiczne badania historycznego przypadku zderzenia między kulturą polską i sowiecką na ziemiach wschodnich II Rzeczypospolitej w latach 1939–1941. Badania przeprowadzono metodą biograficzną, bazując na zastanym materiale pamiętnikarskim. W pierwszej części przybliżono kontekst historyczny przedmiotu badań – pierwszą okupację sowiecką oraz przyjętą perspektywę teoretyczną – kategorię zderzenia kultur. W części drugiej scharakteryzowano wykorzystane w badaniach źródła, sposób wykorzystania metody biograficznej oraz przebieg procedury badawczej. W zakończeniu artykułu zaprezentowano najważniejsze rezultaty badania wybranego przypadku zderzenia kultur metodą biograficzną.
Zmiany sekularne wysokości ciała w przemysłowym regionie Polski
Authors: Puch Elżbieta Alicja
Published: March 2022

The aim of the study was to attempt to assess changes over the last twenty years in the body height of children and adolescents, aged from seven to eighteen years, from the Upper Silesian industrial region of Poland. The data concerning the body height of 1413 children from Katowice, which were collected in 1986, were compared with the mean values of the stature of children and adolescents from Silesian cities where the data were collected between 1964 and 1974. Growth change per decade in each sex-age category was calculated and age-specific curves for secular trends were constructed. These were compared with curves for other industrialised and nonindustrialised regions in the world. In the Upper Silesia the mean values of the body height of children and adolescents of both sexes were measured over the last twenty years. The mean values for puberty rose more than the same values for preand post-puberty. This trend is more clearly marked in boys. Age specific secular trend curves for children from Upper Silesia have an irregular pattern and are significantly different in both sexes. The comparison of our data with data for children and adolescents from other parts of the world (Fig. 3-6) shows that our data adhere to the regular pattern of secular changes that are characteristic for industrial regions. The nature of the age-specific secular trend pattern suggests periodic fluctuations in living conditions. These fluctuations have a negative effect on the physical development of the children concerned.
Detection of Epsilon Toxin in Goats Affected with Acute Enterotoxaemia and the Haemato-biochemical Alterations
Authors: Saravanan S. , Mohanapriya T. , Ramprabhu R.
Published: March 2022

Background: The principal cause of caprine enterotoxaemia is Clostridium perfringens type D which is normally resident in digestive tract and soil in fairly low numbers. Overeating of carbohydrate rich diet or sudden change in diet leads to proliferation of the bacteria and release of lethal toxins in intestine of the host. It causes sudden death in affected ruminants of different ages, though lambs of 3 to 10 weeks of age are highly susceptible. It causes sever enterocolitis with or without haemorrhagic diarrhoea and encephalitis resulting in acute nervous signs with a fatal outcome. Methods: Thirty goats of different breeds under 1-4 years age and both sex were presented to Veterinary Clinical Complex, Veterinary College and Research Institute, Tirunelveli with the neurological signs and diarrhoea were the subject of study. Faecal samples were collected from all these cases and tested on spot by immunochromatographic test kit to identify the Clostridium perfringens Epsilon toxin (ETX). Blood and serum samples were collected and subjected haemato-biochemical analysis. Peripheral blood smears were also collected to rule out haemoprotozoan infections in all the cases. Result: Epsilon toxin was detected from faecal samples of 36.6 per cent of the goats. Diarrhoea was the most consistent finding which is due to enterocolitis in acute cases. A significant increase (P less than 0.001) in the neutrophils and leukocytes count and a significant increase (P less than 0.05) in the levels of BUN, creatinine, glucose, ALP and chloride levels were observed. All the cases were treated with sulphadimidine at recommended dose with supportive therapy but no response was reported due to the fatal encephalitis.
Development of Early Maturing Varieties in Groundnut (Arachis hypogaea L.)
Authors: Vishnuprabha R. Sangeetha , Viswanathan PL. , Manonmani S. , Rajendran L. , Selvakumar T.
Published: March 2022

Background: In view of developing early maturing groundnut that fit in high intensity multiple cropping system the present study was taken up to introgress early maturing traits in the well-established high yielding varieties. Methods: VRI 8, CO 7, ICGV 07222 and VRI 6 were takenas the variety to be improved and as a source for early maturity and male parent in the study viz., VRI 3, Chico, ICGV 91114 and ICGV 93468 were used. A crossing program was designed using these parent materials and selected crosses were forwarded to the next F2 generation and their backcross populations were also generated. The data recorded were subjected to Generation mean analysis and association analysis. Result: With consideration of early maturity and high pod yield the genotypes F2 of CO 7 × Chico and ICGV 07222 × Chico and B2 of ICGV 07222 × Chico recorded high mean values for the traits. The presence of duplicate epistasis was observed for, days to accumulation of 25 flowers (DTF) and days to maturity. This indicates that, inter-mating the selected segregating generations could result in the accumulation of favourable genes. The trait pod yield per plant exhibited positively significant correlation with days to accumulation of 25 flowers, days to maturity in all the crosses and the trait days to accumulation of 25 flowers is positively correlated to days to maturity. Thus, the trait-days to accumulation of 25 flowers is the major selection factor for early maturity in groundnut.
Proximate Analysis, in vitro Dry Matter Degradability and Palatability Index of Legume Residues and Maize Straws for Ruminants
Authors: Hawu O. , Ravhuhali K.E. , Mokoboki H.K. , Lebopa C.K. , Sipango N.
Published: March 2022

Background: Legume residues such as leaves from cowpea and lablab plants can be accumulated in large quantities after fruits harvesting. These legumes can be incorporated in ruminants’ diets due to their high feeding value. They are rich in crude protein, vitamins and minerals when compared to grasses that normally deteriorate during dry seasons. This paper is focusing on determining effect of legume residues and maize straws on in vitro dry matter degradability (IVDMD) and palatability indices in ruminants. Methods: For palatability experiment, each of five male boer goats was provided with four feeding troughs carrying four different feeds (maize straws and 3 legumes = Lablab purpureus - lablab and 2 Vigna unguiculata - cowpeas - Dr Saunders and Betswit). The legume residues and maize straws were also analyzed for chemical composition and IVDMD. All data was subjected to a one-way analysis of variance. Result: Dr Saunders (230.7 g/kg DM) had the highest (P less than 0.05) crude protein content when compared to all diets. Lablab (126.3 g/kg DM) had the lowest (P less than 0.05) acid detergent lignin. The highest (P less than 0.05) condensed tannins concentrations (50.1 g/kg DM) was recorded for Betswit. The highest (P less than 0.05) in vitro dry matter degradability was recorded for lablab at 24 up to 72 hrs. Lablab had a higher palatability index (P less than 0.05) when compared to other diets. Intake (r2 = 0.955) and palatability index (r2 = 0.971) were positively and significantly (P less than 0.05) predicted from total phenolics on goats. Though lablab had better values in most parameters measured, all legumes can be highly recommended to supplement low-quality roughages such as maize straws and grasses.
La gestión educativa para incorporar TIC en bachilleratos rurales indígenas de Oaxaca
Authors: Damián Simón Javier , Estrada López Bany
Published: March 2022

La gestión del directivo es uno de los elementos fundamentales para que los centros escolares cumplan con sus objetivos y brinden un buen servicio educativo a sus estudiantes. El propósito del trabajo es analizar y caracterizar la Gestión Educativa del directivo para lograr la integración de las TIC en el bachillerato rural indígena. Participaron ocho directivos adscritos a igual número de planteles pertenecientes al Instituto de Estudios de Bachillerato del Estado de Oaxaca (IEBO) a los cuales se les aplicó una encuesta para conocer las características del contexto donde operan dichos centros y caracterizar su gestión. Se encontró que el contexto rural e indígena de los centros escolares presentan limitantes financieros y de infraestructura para que los directivos lleven una eficaz Gestión Educativa en sus cuatro dimensiones: pedagógico-curricular, organizacional-operativa, administrativa-financiera y, comunitaria, impulsando escasamente una visión de la importancia de los recursos digitales y fomentar una cultura de aprendizaje apoyada con TIC, por lo cual limitadamente se promueven entornos de aprendizaje creativos e innovadores en el proceso de enseñanza aprendizaje.
Percepción de los profesores hacia la inclusión educativa de estudiantes con TDAH
Authors: Fuentes-Alvarez María Trindiad , Jesús-Zequera Lucitania Altagracia
Published: March 2022

Los estudiantes con el Trastornos por Déficit de Atención con Hiperactividad tienen el derecho de ser incluidos en las escuelas públicas y tener calidad educativa. El objetivo de esta tesis es analizar las percepciones de los profesores entrevistados hacia la inclusión educativa de estudiantes de primaria con TDAH del municipio del Centro del estado de Tabasco del ciclo escolar agosto 2018-julio 2019, para conocer la realidad que perciben. Se utilizo la entrevista semiestructurada con 6 preguntas para la recolección de la información, se analizó por medio del Atlas Ti, orientándose hacia un corte trasversal, el método de análisis fue cualitativo. Como resultado se encontró que los profesores no cuentan con un conocimiento amplio para detección de las características del TDAH, por lo que no saben cómo incluirlos, aunque tienen la actitud para hacerlo, sugieren ser capacitados y realizar trabajo en equipo.
RADIOLOGIC PROGNOSIS OF AN IDIOPATHIC BONE CAVITY OF THE MANDIBLE IN 1-YEAR PERIOD
Authors: Arsan Belde
Published: March 2022

An idiopathic bone cavity (IBC) tends to rise as an abnormality in osseous growth, a degenerating tumoral process, or triggered by hemorrhagic trauma. This paper describes the interpretation of an IBC and its progression over one year. The patient’s initial radiographic images showed well-defined multilocular radiolucency located at the right mandibular molar region, extending between the teeth and the mandibular basis. No clinical symptoms were present, and the course of the mandibular canal was not altered. The lesion was not initially biopsied due to the patient’s dental anxiety. Over one year, the radiolucent area extended anteriorly and thinned the lingual and buccal cortices. Prior radiolucent areas changed to granular-appearing bone. The diagnosis was based on a fine-needle aspiration biopsy. The appearance of an IBC is not unique; its benign nature should be differentiated from multilocular or fibro-osseous lesions by a careful interpretation of clinical and radiological perspectives.
The effect of glide path preparation on the shaping ability of XP-endo® Shaper in simulated canals
Authors: Özlek Esin , Gündüz Hüseyin , Atav Ateş Ayfer
Published: March 2022

Aims: To compare the shaping efficiency of the XP-endo Shaper with or without glide path preparation with sequenced Scout Race files in J-shaped resin blocksMaterial and Methods: Forty simulated J-shaped root canals were classified into two groups (n=20). While the root canals were shaped with XPS after a glide path was created with Scout Race files in Group 1, the same procedures were done without the glide path preparation in Group 2. The pre-and post-instrumentation images were taken and superimposed. Transportation value (TV), centering ability (CA) and the total amount of resin removed (TRR) was calculated by using the obtained images with Adobe Photoshop CS5 software. These parameters were calculated based on 18 reference points (9 inner/9 outer walls) with 1-mm intervals according to 3 sections (coronal, middle, and apical of the canals). The data were analyzed with Kruskal-Wallis and then Dunn's multiple comparison tests (p ≤ 0.05).Results: More resin was removed in Group 2 apical and coronal sections than in Group 1 (p=0.036). In Group 2, a higher transportation value was obtained in apical and middle sections compared to Group 1 (p<0.001). Group 1 showed a higher centering ratio in apical and middle sections than in Group 2 (p<0.001).  The centering ability of the instruments was decreased in the curvature part (middle section) of the canals.Conclusions: Within the limits of this study, glide path preparation using Scout Race instruments improved the shaping ability of XPS instrument by leading to less transportation and maintaining centering ability.
COMPARISON OF RESULTS FROM TWO DIFFERENT LEAKAGE MODELS TO EVALUATE THE APICAL SEALING OF ENDODONTIC MATERIALS
Authors: Santos Goulart Taynara , Antunes Bortoluzzi Eduardo , Hecke Alves Ana Maria , De Lima Pimenta Andrea , Ferreira de Melo Roberto , De Almeida Josiane
Published: March 2022

Introdução: os métodos utilizados para avaliar o selamento apical de materiais obturadores de canais radiculares apresentam algumas limitações e grande variabilidade de resultados pode ser observada. Objetivo: O objetivo deste estudo foi comparar, em modelo de apicificação ex vivo , os resultados dos testes de infiltração bacteriana e de glicose, comunicados em tampões apicais de agregado de trióxido mineral (MTA). Materiais e Métodos: Sessenta segmentos radiculares (12mm) foram divididos aleatoriamente em 2 grupos experimentais (n = 30): G1) MTA; G2) MTA + solução salina tamponada com fosfato intracanal. Metade das responsáveis de cada grupo foi submetido ao teste de infiltração bacteriana com E. faecalispor 70 dias. A outra metade foi submetida ao teste de vazamento de glicose sob pressão (103KPa) por 60 min. Os resultados dos dois testes foram comparados com base no número de corpos de prova que vazamento. Os dados foram obtidos pelo teste de Fisher (p <0,05). Resultados: Não houve diferença entre os testes para os dois grupos importantes (p> 0,05). Conclusão: Os resultados do presente estudo ex vivo demonstraram que não houve diferença entre os métodos de avaliação de vazamento de glicose e bactérias, dentro dos parâmetros do presente estudo e independentemente das limitações.
Reduced myocardial perfusion is common among subjects with ischemia and no obstructive coronary artery disease and heart failure with preserved ejection fraction: a report from the WISE-CVD continuation study
Authors: Aldiwani Haider , Nelson Michael D. , Sharif Behzad , Wei Janet , Samuel T. Jake , Suppogu Nissi , Quesada Odayme , Cook-Wiens Galen , Gill Edward , Szczepaniak Lidia S. , Thomson Louise E. J. , Tamarappoo Balaji , Asif Anum , Shufelt Chrisandra , Berman Daniel , Bairey Merz C. Noel
Published: March 2022

Aim: Women with evidence of ischemia and no obstructive coronary artery disease (INOCA) have an increased risk of major adverse cardiac events, including heart failure with preserved ejection fraction (HFpEF). To investigate potential links between INOCA and HFpEF, we examined pathophysiological findings present in both INOCA and HFpEF. Methods: We performed adenosine stress cardiac magnetic resonance imaging (CMRI) in 56 participants, including 35 women with suspected INOCA, 13 women with HFpEF, and 8 reference control women. Myocardial perfusion imaging was performed at rest and with vasodilator stress with intravenous adenosine. Myocardial perfusion reserve index was quantified as the ratio of the upslope of increase in myocardial contrast at stress vs. rest. All CMRI measures were quantified using CVI42 software (Circle Cardiovascular Imaging Inc). Statistical analysis was performed using linear regression models, Fisher’s exact tests, ANOVA, or Kruskal-Wallis tests. Results: Age (P = 0.007), Body surface area (0.05) were higher in the HFpEF group. Left ventricular ejection fraction (P = 0.02) was lower among the INOCA and HFpEF groups than reference controls after age adjustment. In addition, there was a graded reduction in myocardial perfusion reserve index in HFpEF vs. INOCA vs. reference controls (1.5 ± 0.3, 1.8 ± 0.3, 1.9 ± 0.3, P = 0.02), which was attenuated with age-adjustment. Conclusion: Reduced myocardial perfusion reserve appears to be a common pathophysiologic feature in INOCA and HFpEF patients.
Lysosome-mediated chemoresistance in acute myeloid leukemia
Authors: Cuesta-Casanovas Laia , Delgado-Martínez Jennifer , Cornet-Masana Josep M. , Carbó José M. , Clément-Demange Lise , Risueño Ruth M.
Published: March 2022

Despite the outstanding advances in understanding the biology underlying the pathophysiology of acute myeloid leukemia (AML) and the promising preclinical data published lastly, AML treatment still relies on a classic chemotherapy regimen largely unchanged for the past five decades. Recently, new drugs have been approved for AML, but the real clinical benefit is still under evaluation. Nevertheless, primary refractory and relapse AML continue to represent the main clinical challenge, as the majority of AML patients will succumb to the disease despite achieving a complete remission during the induction phase. As such, treatments for chemoresistant AML represent an unmet need in this disease. Although great efforts have been made to decipher the biological basis for leukemogenesis, the mechanism by which AML cells become resistant to chemotherapy is largely unknown. The identification of the signaling pathways involved in resistance may lead to new combinatory therapies or new therapeutic approaches suitable for this subset of patients. Several mechanisms of chemoresistance have been identified, including drug transporters, key secondary messengers, and metabolic regulators. However, no therapeutic approach targeting chemoresistance has succeeded in clinical trials, especially due to broad secondary effects in healthy cells. Recent research has highlighted the importance of lysosomes in this phenomenon. Lysosomes’ key role in resistance to chemotherapy includes the potential to sequester drugs, central metabolic signaling role, and gene expression regulation. These results provide further evidence to support the development of new therapeutic approaches that target lysosomes in AML.
Combating CHK1 resistance in triple negative breast cancer: EGFR inhibition as potential combinational therapy
Authors: Stefanski Casey D. , Prosperi Jenifer R.
Published: March 2022

Triple negative breast cancer (TNBC) is marked by a lack of expression of the Estrogen Receptor, Progesterone Receptor, and human epidermal growth factor receptor 2. Therefore, targeted therapies are being investigated based on the expression profiles of tumors. Due to the potential for acquired and intrinsic resistance, there is a need for combination therapy to overcome resistance. In the article by Lee et al., the authors identify that, while prexasertib (a CHK1 inhibitor) lacks efficacy alone, combination with an EGFR inhibitor provides synergistic anti-tumor effects. Advances in targeted therapy for TNBC will benefit the clinical landscape for this disease, with this study initiating a new avenue of investigation.
Strategic Stability and Chinese Gambit
Authors: Arbatov A.
Published: March 2022

During the last three years, the prospects of engaging China in the process of nuclear disarmament has moved to the forefront of the arms control agenda. In 2019–2020, it was made the top issue by the Donald Trump’s administration when it withdrew from the Treaty on the Elimination of Intermediate-Range and Shorter-Range Missiles (INF Treaty) and refused to prolong the Treaty on Measures for the Further Reduction and Limitation of Strategic Offensive Arms (the New START). As for Beijing, it flatly rejected US demands to join arms control and this position was endorsed by Moscow. Thanks to the Joseph Biden’s administration coming to power in January 2021, the New START was extended by five years in February of the same year. In June, the summit of the presidents of Russia and the United States was held in Geneva, and in July, the official dialogue on strategic stability was launched. However, during the same summer, an unexpected event happened. Independent U. S. experts published information from commercial satellites, which revealed an ongoing construction of three large military bases in central areas of China with hundreds of new silo launchers for intercontinental missiles. Afterwards, the Pentagon confirmed this information and predicted that Chinese missiles buildup may reach the level of about 1000 or more nuclear warheads by the year 2030. This news was neither confirmed nor denied by the official Beijing. However, together with continuing Chinese deployment of strategic ballistic missile nuclear submarines, forthcoming introduction of heavy bombers, expanding early warning satellites and tests of antisatellite systems – these developments imply the fundamental shift in the global and regional strategic balances with profound political consequences. American response to China’s strategic buildup and Russian reaction to the U.S. military innovations may entail a next massive cycle of arms race and would cause a new stagnation at the negotiations of the two nuclear superpowers – all highly detrimental to international security. Nonetheless, there is still a chance of reinvigorated diplomatic effort at the U.S. – Russian and U.S. – Chinese tracks, which might lay the foundation of the future multilateral framework of strategic stability.
Financing of Inovations and Sovereign Funds
Authors: Strelets I. , Chebanov S.
Published: March 2022

Technology turned to be a virtual bedrock of the contemporary global economy. The prospects for successful overcoming of the multiple social, environmental, economic and geo-political strains that are challenging the future of the mankind mainly depend on the technological progress in all spheres of life. The development and large-scale introduction of qualitatively new, in many cases disruptive, technologies demand accumulation and efficient allocation of huge amounts of resources, primarily the financial ones. Since the global financial crisis of 2008–2009 sovereign wealth funds proved to be some of the most well-capitalized institutional investors and substantially increased their role in the international economic architecture. Currently, total disclosed assets under management (AUM) of 95 active state-run funds are estimated at about 9 Trillion US dollars, which presents almost 10% of the total worldwide AUM. Even more importantly, thanks to the structure of capital and statutory mandates, they can take a longer view on value creation and, thus, on operations’ planning as compared to venture funds, PE funds and other counterparts from the private sector. Far-reaching investment horizon is a feature that is critical and highly welcomed in such capital-demanding and volatile sphere as financing of innovations. According to available data, in recent years the leading sovereign wealth funds joined the global race in technologies and noticeably increased their investments in the technological sector, including transition to “green” economy, clean energy, digitalization of production, transportation and distribution, ICT-based services and business platforms. This trend can be traced since mid 2010s. Even in pandemic 2020 sovereign funds were most active in the technology sector (25% of all registered deals). The second and the third places were taken by services (including e-commerce infrastructure) and life sciences (vaccines): 18 and 17.6% respectively. This data is based on the analysis of 165 fresh annual deals worth 42 Billion US dollars. The sovereigns’ trend to get closer to the technological assets (instead of traditional equities and mortgage) is being accompanied by greater in-house expertise and skills, general sophistication of strategies and operational management. This is especially true in cases of direct investments and access to early-stage technology-focused ventures. The empirical evidence allows to expect that in a foreseeable future the sovereign wealth funds will be steadily increasing their roles in financing of global innovations.