bluuebunny/crossref_metadata_2025 huggingface dataset:
Supplementary Figure 2 from Immune Profiling of Vulvar Squamous Cell Cancer Discovers a Macrophage-rich Subtype Associated with Poor Prognosis
Authors: Condic Mateja , Rohr Andrea , Riemann Soheila , Staerk Christian , Ayub Tiyasha H. , Doeser Anna , Zillinger Thomas , Merkelbach-Bruse Sabine , Buettner Reinhard , Barchet Winfried , Rudlowski Christian , Mustea Alexander , Kübler Kirsten
Published: March 2024

Supplementary Figure 2 shows analysis in independent validation cohorts.
Data from Immune Profiling of Vulvar Squamous Cell Cancer Discovers a Macrophage-rich Subtype Associated with Poor Prognosis
Authors: Condic Mateja , Rohr Andrea , Riemann Soheila , Staerk Christian , Ayub Tiyasha H. , Doeser Anna , Zillinger Thomas , Merkelbach-Bruse Sabine , Buettner Reinhard , Barchet Winfried , Rudlowski Christian , Mustea Alexander , Kübler Kirsten
Published: March 2024

Abstract
The incidence rates of vulvar squamous cell cancer (VSCC) have increased over the past decades, requiring personalized oncologic approaches. Currently, lymph node involvement is a key factor in determining prognosis and treatment options. However, there is a need for additional immune-related biomarkers to provide more precise treatment and prognostic information. Here, we used IHC and expression data to characterize immune cells and their spatial distribution in VSCC. Hierarchical clustering analysis identified distinct immune subtypes, of which the macrophage-rich subtype was associated with adverse outcome. This is consistent with our findings of increased lymphogenesis, lymphatic invasion, and lymph node involvement associated with high macrophage infiltration. Further in vitro studies showed that VSCC-associated macrophages expressed VEGF-A and subsequently induced VEGF-A in the VSCC cell line A-431, providing experimental support for a pro-lymphangiogenic role of macrophages in VSCC. Taken together, immune profiling in VSCC revealed tumor processes, identified a subset of patients with adverse outcome, and provided a valuable biomarker for risk stratification and therapeutic decision making for anti-VEGF treatment, ultimately contributing to the advancement of precision medicine in VSCC.
Significance:
Immunoprofiling in VSCC reveals subtypes with distinct clinical and biological behavior. Of these, the macrophage-rich VSCC subtype is characterized by poor clinical outcome and increased VEGF-A expression, providing a biomarker for risk stratification and therapeutic sensitivity.
Combination Assay of Methylated HOXA1 with Tumor Markers Shows High Sensitivity for Detection of Early-Stage Hepatocellular Carcinoma
Authors: Kunimune Yuki , Suehiro Yutaka , Saeki Issei , Yamauchi Yurika , Tanabe Norikazu , Matsumoto Toshihiko , Higaki Shingo , Fujii Ikuei , Suzuki Chieko , Okayama Naoko , Nishioka Mitsuaki , Ichihara Kiyoshi , Nagano Hiroaki , Sakaida Isao , Takami Taro , Yamasaki Takahiro
Published: March 2024

Introduction: Patients with hepatitis virus-related hepatocellular carcinoma (viral HCC) are decreasing as hepatitis control improves, but those with non-viral-related HCC (non-viral HCC) are increasing in Japan. No established surveillance system exists for patients with non-viral HCC, so they are often diagnosed at an advanced stage. To address this, we performed this study. Methods: We collected serum samples from 516 participants (154 healthy subjects, 93 chronic liver disease [CLD] patients without HCC, and 269 HCC patients). Participants were divided into a control group comprising healthy subjects and patients with CLD and an HCC group. We evaluated serum methylated HOXA1 (m-HOXA1) copy numbers using modified combined restriction digital PCR (CORD) assay (1-step CORD assay). We assessed diagnostic performance of m-HOXA1 compared to HCC tumor markers alpha-fetoprotein (AFP) and des-gamma-carboxy prothrombin (DCP) and created a novel index to improve HCC prediction. Results: Serum m-HOXA1 level was significantly higher in each HCC stage group versus the control group. Its sensitivity was 69.1% and specificity was 78.5% for diagnosing HCC. The area under the curve (AUC) of m-HOXA1 was superior to that of AFP and equal to that of DCP. Multivariate logistic regression analysis revealed independent contributions of m-HOXA1, DCP, and AFP, in that order of strength, to diagnose HCC after adjustment for age and sex. We designated the predictive probability of HCC based on the regression model as the ASDAm-H1 (Age, Sex, DCP, AFP, and m-HOXA1) index. Its diagnostic accuracy was 0.96 by AUC with a sensitivity of 86.2% and specificity of 93.9%. Sensitivity was identical for viral and non-viral HCCs. When limited to early-stage HCC, sensitivity of the ASDAm-H1 index was 76.3%. Conclusions: We showed distinguished performance of the ASDAm-H1 index to detect viral and non-viral HCC, even at an early stage. This index might have potential as a non-viral HCC surveillance system.
As seis pinturas de Massimo Campigli do MAC USP discutidas sob o olhar das artes plásticas e dos resultados de análises com técnicas de imagens e espectroscópicas
Authors: Rocco Renata Dias Ferraretto Moura , Rizzutto Márcia de Almeida , Schenatto Julia , Bovolenta Juliana Bittencourt , Engel Wanda Gabriel Pereira
Published: March 2024

This article focuses on the discussion of the results obtained with non-invasive image and spectroscopic analyzes (to determine chemical elements and compounds) on the six paintings by the German artist, naturalized Italian, Massimo Campigli, that belong to the collection of the Museum of Contemporary Art of the University of São Paulo (MAC USP). Aspects of the artist’s trajectory, the plastic solutions of the artworks, along with the analyzes made with the spectroscopic techniques of energy dispersive X-ray fluorescence (ED-XRF), Raman, and Fourier transform infrared (FTIR), and the imaging techniques of visible photography (VIS), raking light (RAK), transmitted light (TRANS), visible ultraviolet fluorescence (UVF), infrared reflectography (IRR), and radiography (RAD) offer important information on the artist and on his work. These non-invasive analyzes were carried out in the museum itself with portable equipment from the Laboratory of Archaeometry and Applied Sciences to Cultural Heritage (LACAPC) of the Physics Institute (IF) of USP. Overall, the results obtained corroborate with Campigli’s testimonies about his artistic practice, as well as those of people who saw him working in his studio. His palette choice, composed by natural and synthetic pigments, mostly whites and paints with earthy tones, and his creative steps of creating and recreating the paintings, reusing canvases many times, were proven to be true with the analytical investigations.
Nos rastros da Copa do Mundo FIFA 2014: reflexões críticas sobre a produção do espaço urbano em Itaquera, São Paulo, SP
Authors: Baumgaertner Jaqueline Floria
Published: March 2024

The 2014 FIFA World Cup in Brazil gave rise to a series of studies on the production of space and tourism and the participation of mega-events in urban planning. The planning of the space aimed at hosting the FIFA World Cup reoriented the social practice of the host cities and deepened the existing segregations. This work aims to analyze the process of production of urban space as a result of mega-events based on the case study of the neighborhood of Itaquera, São Paulo, based on a critical perspective and considering the demands of the population. From the neoliberal perspective of strategic planning applied in cities, we seek to understand the production of space in the host city, from the point of view of public decisions and also from the perception of the local population. For this, interviews were conducted with residents of Itaquera. When reflecting on Itaquera, we identify that a new centrality is established, which helps us to understand the ongoing processes of space production in the region. Although part of the urban transformations took place during the city's preparation period for the mega-event, the criticism presented in this work rests on a modus operandi according to which the collective production of a fairer and more accessible space for the population effectively did not come true.
Colchicine’s Role in Cardiovascular Disease Management
Authors: Buckley Leo F. , Libby Peter
Published: March 2024

Colchicine—an anti-inflammatory alkaloid—has assumed an important role in the management of cardiovascular inflammation ≈3500 years after its first medicinal use in ancient Egypt. Primarily used in high doses for the treatment of acute gout flares during the 20th century, research in the early 21st century demonstrated that low-dose colchicine effectively treats acute gout attacks, lowers the risk of recurrent pericarditis, and can add to secondary prevention of major adverse cardiovascular events. As the first Food and Drug Administration–approved targeted anti-inflammatory cardiovascular therapy, colchicine currently has a unique role in the management of atherosclerotic cardiovascular disease. The safe use of colchicine requires careful monitoring for drug-drug interactions, changes in kidney and liver function, and counseling regarding gastrointestinal upset. Future research should elucidate the mechanisms of anti-inflammatory effects of colchicine relevant to atherosclerosis, the potential role of colchicine in primary prevention, in other cardiometabolic conditions, colchicine’s safety in cardiovascular patients, and opportunities for individualizing colchicine therapy using clinical and molecular diagnostics.
Reversed Effect of Eccentricity: Perceived Duration of Peripherally Presented Stimuli Depends on Time Span
Authors: Krug Alina , Eberhardt Lisa Valentina , Pittino Ferdinand , Huckauf Anke
Published: March 2024

The perceived duration of stimuli presented in the visual periphery decreases with increasing eccentricity for brief durations. However, studies using different experimental methods or longer durations have reported inconsistent results. The present study aims to systematically explore the impact of stimulus eccentricity on perceived duration across various duration ranges. In three experiments employing the temporal bisection task, participants categorised the duration of stimuli presented at 3° or 9° of eccentricity as rather short or long, referred to two anchor durations previously learned. Stimulus durations varied between experiments and included short durations of 20–220 ms (Experiment 1), long durations of 400–1600 ms (Experiment 2), and intermediate durations of 160–660 ms (Experiment 3). For the short durations of Experiment 1, the results again replicated the decrease in perceived duration with increasing eccentricity. Interestingly, for the long durations, the effect was reversed, while subjective duration did not differ significantly between eccentricities for the intermediate durations. We discuss the findings with respect to prominent models of time perception, considering potential differences in attentional processing of short and long durations.
One Hundred Thousand Greetings!
Authors: Sheikh Hossein
Published: March 2024

The Judeo-Persian texts from the Afghan Ginza provide us with unique information about the Jewish communities in Central Asia before the Mongol invasion. Among these texts, some letters can be considered not only the earliest evidence of the New Persian language, but more specifically the earliest evidence of the epistolary tradition in New Persian. This paper examines the opening sections of these letters in order to demonstrate and discuss the changes and the evolution of the opening formulae over time.
2. Pretensions to Permanency
Authors: Beevers Robert
Published: March 2024

In Chapter 2, ‘Pretensions to Permanency: Thorvaldsen’s Bust and Statue of Byron’ (1995), Robert Beevers focuses on Lord Byron’s connection with the world of art, particularly with the Danish sculptor Bertel Thorvaldsen. The chapter explores the background to John Cam Hobhouse’s commissioning of Byron’s bust, revealing Hobhouse’s personal attachment and anticipation of a potential separation from Byron. The choice of Thorvaldsen, a prominent Neo-Classical sculptor, is discussed in the context of Hobhouse’s enthusiasm for classical antiquity. Byron’s relationship with the fine arts is explored, acknowledging his occasional indifference to but deep appreciation of painting and sculpture. The sculptor’s admiration for Byron is highlighted, suggesting a recognition of the poet’s spirit that transcends artistic conventions. Beevers’s narrative describes the journey of the Byron memorial monument, from its creation to a prolonged storage period caused by religious objections to its location in Westminster Abbey. Trinity College emerges as a solution and the chapter concludes with Hobhouse’s reluctant acceptance of the monument’s placement in the Wren Library, considering it a form of exile for Byron in effigy. The pamphlet written by Hobhouse to argue his case is mentioned, emphasizing his deep appreciation for Byron and the symbolic rejection felt in the statue's relocation.
4. Poets and Travellers
Authors: St Clair William
Published: March 2024

Chapter 4, ‘Poets and Travellers’ (1998), explores various aspects of Lord Byron’s literary and political engagements, beginning by focusing on his satirical work ‘English Bards and Scotch Reviewers.’ William St Clair details the poem’s tumultuous publication history, marked by its rejection by London publishers, discussing the complexities of forgeries and controversy surrounding the poem. The chapter then shifts to Byron’s involvement with the Elgin Marbles and his critical stance on Lord Elgin’s actions, seen in his poem ‘The Curse of Minerva’. The discussion extends to Byron’s influential work Childe Harold's Pilgrimage, controversial for attacking Lord Elgin and addressing the removal of the Elgin Marbles. Byron's influence on the Philhellenic movement and his use of romantic poetry conventions, coupled with explanatory notes, contribute to ongoing debates about Greece's historical and cultural significance.
Innovation in Forest Management in Burkina Faso: Analyzing the Dynamics of the Actor-Network in Cassou
Authors: Sibiri Birba , Eveline Compaoré , Patrice Toé , Souleymane Ouedraogo
Published: March 2024

The challenges of sustainable forest preservation led Burkina Faso to implement participatory forest management projects in the mid-80s. These projects led to the creation of Forest Management Sites including the one at Cassou. This innovative approach focusses on the active participation of the local communities. It raised high hopes for sustainable forest management. This presents paper traces the process and analyze the outcome derived from the participatory forest management. The Actor-network theory was used as to analyze the implementation process of the CAF model. In doing so, qualitative approach was used through key experts’ and stakeholders’ interviews and focus groups discussions to understand the trajectory and to evaluate the process of implementing the given model. The results show that the dynamic that prevailed at the beginning of the process has eroded over time to the point that after more than three decades of implementation, the model has not yet reached its phase of stabilization or irreversibility. Actors no longer seem to refer to the roles assigned to them, and they are not respecting their commitments. In part, factors such as population renewal and growth, decentralized development management (which were not taken into account at the outset) call for new forms of negotiations between stakeholders to regain control of the process for the sack of the Cassou managed forest.
Effect of Bone Char Application on Soil Quality, Soil Enzyme and in Enhancing Crop Yield in Agriculture: A Review
Authors: Bayata Adugna , Mulatu Getachew
Published: March 2024

Soil quality, in contrast to air or water, exhibits a heightened level of heterogeneity and necessitates closer examination due to its impact on the well-being of flora, fauna, and human beings. Organic carbon is considered a fundamental indicator of soil quality, as it plays a significant role in strategies aimed at mitigating climate change. The generation of bone char arises from a thermochemical conversion process involving defatted bones. Specific attention is focused on the solubility of P compounds, which serves to classify bone chars as potential slow-release P fertilizers. The introduction of P into the soil can be enhanced through an "internal activation" process facilitated by the adsorption of reduced S compounds. Additional properties of agronomic significance originate from the porosity of bone char, which promotes water retention and provides a habitat function for soil microorganisms. The evaluation of soil quality has been a longstanding practice, involving an examination of physical and chemical characteristics such as pH, nitrogen levels, soil organic carbon, bulk density, accessible water, aggregate stability, particle size distribution, and soil structure. Recently, the concept of soil quality has been expanded to encompass the notion of soil health, which is perceived as a finite, non-renewable resource that undergoes constant change. Research also demonstrates the crucial role of soil biota in the assessment of soil quality, as they exhibit rapid responsiveness to disturbances. Animal bones undergo a process of defatting, degelatinization, and subsequent incineration at temperatures ranging from 600-800°C to produce bone char (BC). Reports indicate that typical BC contains 152 g P kg-1, 280 g Ca kg-1, and 6.5 g Mg kg-1, with carbon content typically falling below 100 g kg-1. The solubility of bone char in the soil depends on factors such as pH and the soil's capacity to absorb P, situating it within the range between rock phosphate and triple super phosphate (TSP). The application of bone char to the soil can enhance soil health, resulting in increased crop yield and improved quality.
Wifi Pentesting Roadmap for Classic-Future Attacks and Defenses
Authors: Malalatiana Ramafiarisona Hajasoa , Sitraka Rakotondramanana Radiarisainana
Published: March 2024

The most advanced attack on the Wireless Fidelity (WIFI) network uses social engineering. The hacker makes portal captive and forces the victim for disconnecting to internet instead of entering the real password of the WIFI. In normal actions, asking WIFI password on the web interface is not the real process, but sometimes the victim is not experience enough on security and thinks that it is a technical problem. Also, the victim didn’t have internet connection due to the hard deauthentication and the select open access, which is not his WIFI network. The future generation of WIFI could be use a secure deauthentication. So, this article proposed how the actual attack will be processed, how is the secure deauthentication and how hacker could use this same attack with more secure network. Like conclusion, solutions to resolve this problem will be proposed. New hacking arsenal for replacing the deauthentication is the smart-jamming. With the secure deauthentication, reforging the packet for telling the victim to deauthenticate to the network will not be possible anymore. The smart-jamming select the frequency of the access point of the victim and jam only this specific frequency by sending a noise. In this scenario, the same effect of the first attack is still possible. For the best security of network, two solutions will be proposed: secure deauthentication and hopping frequency. A defensive proposition about secure deauthentication will be found in this article by using cryptographic key exchange like Diffie Hellman (DH), Elliptic Curve Diffie Hellman (ECDH) and Super Isogenies Diffie Hellman (CSIDH).
A Study on Pre-clinical Anaesthesia Elective in Shaping Medical Students' Knowledge and Career Perspectives
Authors: Hauck Jeffrey , Angelov Ivan , Silcox Kelli , Khalifa Ali
Published: March 2024

Anesthesiology stands out as one of the rapidly growing and highly competitive medical specialties, necessitating students to cultivate an interest in anesthesia early and prepare extensively for clinical electives. Pre-clinical electives that introduce students to anesthesia and ready them for clinical settings in the early stages of their academic journey may confer benefits and enhance their competitiveness as residency applicants. This study implemented an eight-week pre-clinical elective titled "The History of Anesthesia" for first- and second-year students at Baylor College of Medicine. Eighty-eight students participated in the elective, with thirteen completing both pre-course and post-course surveys. The survey, consisting of thirteen questions related to anesthesia interest and relevant clinical knowledge, was analyzed, and statistical significance was calculated. The survey results demonstrated significantly elevated levels of self-assessed knowledge in the post-course survey compared to the pre-course survey (p < .05). Notably, topics considered more clinically relevant, such as modern anesthetic techniques, regional anesthesia, and obstetric anesthesia, exhibited significantly higher average survey results in the post-course compared to the pre-course results. The implementation of pre-clinical electives focusing on success in clinical settings appears beneficial for students aspiring to apply to an anesthesiology residency. Institutions should consider exposing students to anesthetic topics earlier in their academic journey to adequately prepare them for the competitive residency application process.
Adoption Analysis of BADC Produced Boro Rice Seed and Its Impact on Farm Household Food Security in Bangladesh
Authors: Mia Md. Shahin , Uddin Md. Taj , Kabir Humayun , Miah Md. Abdul Monayem , Salam Md. Abdus
Published: March 2024

The purpose of this study is to look into the factors that influence adoption of BADC produce Boro rice seed and its impact on farm household food security in Bangladesh. The endogenous switching regression model (ESRM) and the propensity score matching (PSM) method were employed to identify the factors that influence adoption of BADC Boro rice seed and assessed its adoption impact on farm household food security. The analysis revealed that age, farm size, rice area, farm income, extension service, livestock ownership and government assistance had significant influence on adoption of BADC Boro rice seed. The estimated results show that education, farm size, earning members, farm income had positive and significant influence in attaining food security status of both adopters and non-adopters farm household. The estimated coefficient of correlation between the adoption equation and the food security equation of adopters was positive and significant. The study confirms that BADC produce Boro rice seed adoption had positive and significant impact on farm household food security of Bangladesh. The study recommended that BADC should implement appropriate policies to increase Boro rice seed production and enhance its adoption level through extension service so that food security situation improve in Bangladesh.
The Comparative Study of Metaphorical Images Translation Strategies in Tang Poetry
Authors: Xia Yu , Xiaojuan Fan
Published: March 2024

In Tang poetry, metaphorical images serve as powerful tools for poets to convey their emotions and experiences in a vivid and imaginative manner. These images, drawn from nature, mythology, history, and daily life, allow poets to create rich and layered meanings that resonate with readers across time and culture. The use of metaphorical images in Tang poetry reflects the deep poetic tradition and artistic sensibility of Chinese literature. Translating metaphorical images from Tang poetry into English poses a unique challenge for translators due to the cultural and linguistic differences between the two languages. However, this challenge also presents an opportunity for translators to exercise creativity and interpretation in conveying the essence of the original poems. By carefully selecting appropriate English equivalents for the metaphorical images, translators can capture the beauty and complexity of Tang poetry for English-speaking audiences. Through a comparative analysis of translation strategies employed in representative cases of Tang poetry, this paper combines case study and corpus analysis methods to explore the concept and function of metaphorical images in Tang poetry, analyzes the possibility and importance of its English translation, and provides a comparative analysis of translation strategies for metaphorical images using representative cases of Tang poetry translation. It reveals the rationality and fidelity of translating metaphorical images.
Financial System Development and Economic Growth: A Critical Analysis of the Literature
Authors: Megnigang Denise Gisèle
Published: March 2024

Any developing countries (DCs) want to achieve strong, sustained growth to ensure their sustainable development by 2030. Indeed, promoting economic growth is one of the targets of the majority of the Sustainable Development Goals (SDGs) set by United Nations member countries. In their agenda, financial system development cited as an effective means of enabling developing countries to achieve high rates economic growth. However, research into the relationship between finance and growth has produced controversial results, showing that financial development is not always conducive to economic growth. These non-consensual findings call for further research into the subject. With this in mind, the aim of this paper is to critically analyze the literature on the subject with reference to the characteristics of developing countries. We have used the stylistic facts observed in these countries to see whether the way in which studies are conducted is in line with reality. These facts revealed that, as conducted, theoretical and empirical work does not really illustrate the nature of this relationship in the case of developing countries. The authors do not take into account certain specificities of these countries. The studies focus mainly on the formal financial sector, whereas in developing countries, the majority of the population is unbanked, so they tend to turn to the informal financial sector for savings and credit. In Pagano's theoretical model, on which most empirical work is based, the efficiency of financial intermediation is assumed to be an exogenous variable. However, in developing countries, many factors influence this function: poor governance, prevailing corruption, inefficiency of the legal system, government intervention in the financial sector, culture of non-repayment. Banking sector development is generally captured by credit to the private sector. However, in developing countries, the majority of bank credit is allocated to large commercial enterprises that sell mainly imported products. The indicators generally used to capture financial markets development do not reflect the amount of financing actually obtained by listed companies. Rather, they measure the level of secondary market activity, whose mission is to ensure the liquidity of securities and determine their prices. Taking account of financial dualism and integrating factors linked to the institutional environment, borrower behavior and financial intermediaries into the resource allocation function would be a significant advance in the literature.
Algebraic Representation of Primes by Hybrid Factorization
Authors: Papadakis Ioannis N. M.
Published: March 2024

The representation of integers by prime factorization, proved by Euclid in the Fundamental Theorem of Arithmetic −also referred to as the Prime Factorization Theorem− although universal in scope, does not provide insight into the algebraic structure of primes themselves. No such insight is gained by summative prime factorization either, where a number can be represented as a sum of up to three primes, assuming Goldbach’s conjecture is true. In this paper, a third type of factorization is introduced, called hybrid prime factorization, defined as the representation of a number as sum −or difference− of two products of primes with no common factors between them. By using hybrid factorization, primes are expressed as algebraic functions of other primes, and primality is established by a single algebraic condition. Following a hybrid factorization approach, sufficient conditions for the existence of Goldbach pairs are derived, and their values are algebraically evaluated, based on the symmetry exhibited by Goldbach primes around their midpoint. Hybrid prime factorization is an effective way to represent, predict, compute, and analyze primes, expressed as algebraic functions. It is shown that the sequence of primes can be generated through an algebraic process with evolutionary properties. Since prime numbers do not follow any predetermined pattern, proving that they can be represented, computed and analyzed algebraically has important practical and theoretical ramifications.
On Fuzzy Baire-Separated Spaces and Related Concepts
Authors: Thangaraj Ganesan , Raji Natarajan
Published: March 2024

In this paper, a new class of fuzzy topological spaces, namely fuzzy Baire-separated spaces is introduced in terms of fuzzy Baire sets. Several characterizations of fuzzy Baire-separated spaces are established. It is shown that fuzzy Baire sets lie between disjoint fuzzy P-sets and fuzzy Fσ- sets in a fuzzy Baire-separated space. Conditions under which fuzzy topological spaces become fuzzy Baire-separated spaces are established. Fuzzy nowhere dense sets are fuzzy closed sets in fuzzy nodec spaces and subsequently a question will arise. Which fuzzy topological spaces [other than fuzzy hyperconnected spaces, fuzzy globally disconnected spaces] have fuzzy closed sets with fuzzy nowhere denseness? For this, fuzzy topological spaces having fuzzy closed sets with fuzzy nowhere denseness are identified in this paper. It is verified that fuzzy ultraconnected spaces are non fuzzy Baire -separated spaces. The means, by which fuzzy weakly Baire space become fuzzy Baire -separated spaces and in turn fuzzy Baire - separated spaces become fuzzy seminormal spaces, are obtained. There are scope in this paper for exploring the inter-relations between fuzzy Baire spaces and Baire -separated spaces.
Knowledge, Attitudes and Practices of Breast Self-Examination Among Women Aged 35 to 65 Years in the Commune of Mbour (Senegal)
Authors: Gueye Boubacar , Bassoum Omar , Diagne Ndéye Marième , Bop Martial Coly , Tall Alioune Badara , Ndiaye Abdoul Aziz , Diop Cheikh Tacko , Sow Papa Gallo , Ka Ousseynou
Published: March 2024

Introduction: Breast cancer is second only to cervical cancer in Senegal. It has a high mortality rate because of its late diagnosis and the inadequacy and availability of treatment. In countries with limited resources, breast self-examination is still a means of early diagnosis of breast cancer. The aim of the study was to assess knowledge, attitudes and practice of BSE in the commune of Mbour. Methods: This was a descriptive and analytical cross-sectional study that took place from 01 to 30 July 2022 in the commune of Mbour. The study population consisted of women aged 35 to 65 years who had been living in the study area for more than three months. Sampling was carried out using a two-stage cluster survey. Results: A total of 599 women were surveyed. The average age of the women was 44.3 years. Educated women represented 56.3% of the sample. Married women accounted for 81.4% of the sample and those engaged in an income-generating activity 64.9%. The overall level of knowledge was average, with 57.9% correctly answering questions about breast cancer and breast self-examination. The most frequent sources of information are the media, with television (77.1%), radio (53.4%) and written media (35.2%). Health professionals are also an important source of information, with 43.9% of women informed by this source. Overall, 78.5% (471) of the women surveyed had the 'right' attitude and 20.9% the 'wrong' attitude. We noted in the series that 10.9% (65) of women performed breast self-examination adequately according to the recommended technique. However, 22.7% (136) of women performed BSE inadequately. The practice of BSE was higher in women over 50 (72.3%) than in women under 50, with a statistically significant difference (p<0.05). It is noted that women's level of education had a significant influence (p<0.05) on the practice of BSE, with 69.2% of women who practiced BSE being educated. In contrast, women's marital status and the exercise of income-generating-activity among women had no influence on the practice of BSE. Conclusion: In order to improve the practice of breast self-examination, it is important to strengthen communication aimed at women through the media and healthcare personnel.
Evaluating the Effects of Deficit Irrigation and Mulch Type on Yield and Yield Components of Onion in Fogera, Ethiopia
Authors: Mekonen Belachew Muche , Gelagile Demsew Bekele
Published: March 2024

Water scarcity is a challenge for current irrigated agriculture globally. Under these circumstances, new on-farm irrigation management strategies should be established. An experiment was conducted at Fogera in 2021 to evaluate the effects of deficit irrigation (DI) and mulch type on onion yield and yield components. A factorial combination of three levels of DI (100%ETc, 75%ETc, and 50%ETc) and three mulch types No Mulch (NM), White Plastic Mulch (WPM), and Rice Straw Mulch (RSM)) were evaluated in RCBD with three replications. Monthly ETo, ETc, and irrigation scheduling were computed using CROPWAT 8.0 model. These studies showed that the onion yield and yield components were significantly affected by the main and the interaction effects. The maximum average plant heights (PH), leaf heights (LH), and number of leaves per plant (LNP) of 51.7 cm, 38.0cm, and 10.4 respectively, were recorded from 100%ETc whereas the minimum PH, LH, and LNP of 39.5 cm, 29.0cm, and 6.9 were recorded from 50%ETc treatment respectively. The highest average bulb weight (BW), bulb diameter (BD), and bulb height (BH) were 117.9gr, 6.4, and 5.7 cm recorded from 100%ETc treatment respectively. In contrast, the minimum average BW, BD, and BH were 79.9gr, 4.8, and 5.0cm recorded from 50%ETc respectively. The highest PH, LH, and LNP of onions were 51.9cm, 40.6cm, and 10.1 respectively recorded from RSM treatments. In contrast, the minimum PH, LH, and LNP of onions were 41.5cm, 31.1cm, and 7.5 respectively, recorded from WPM treatments. Similarly, the highest mean BW, BH, and BD 106.2gr, 5.8cm, and 6.0cm were obtained from the treatments of RSM respectively. In contrast, the lowest mean BW, BH, and BD 100.7gr, 5.0cm, and 5.3cm were obtained from NM treatments respectively. The interaction effects of DI and mulch showed that the onion yield at 100%ETc with RSM was 7.5% higher than that at 100%ETc with NM and 15.1% higher than the yield at 100%ETc with PM. The highest BW, BH, and BD of the onion 121.8 gr, 6.2, and 6.8 were obtained when the onions received 100%ETc and mulched with RS while the lowest average BW, BH, and BD of the onion were 77.3gr, 4.6cm and 4.1cm were obtained from 50%ETc with NM treatment combination. These results showed that RSM with 75%ETc improves onion yield and yield components.
Interpretation: Time, Timing, Loss, and Recovery in the Analytic Hour
Authors: Zeavin Lynne
Published: March 2024

Interpretation remains relevant in contemporary psychoanalysis and serves a crucial linking function between patient and analyst. Interpretation provides an important link with temporalities: the time of the analytic hour and the time of the patient’s history as it unfolds in the present. Analysis, it is argued, is bounded by time and loss. Two case vignettes, presented from a Kleinian perspective, exemplify these propositions.
Comparison of Clinicopathological Features of Pleomorphic and Invasive Lobular Breast Carcinomas
Authors: Sağdıç Mehmet F. , Güler Onur C. , Subaşı Orkun , Albayrak Özhan , Özaslan Cihangir
Published: March 2024

Purpose

Accounting for about 15% of invasive lobular carcinomas and 1% of breast carcinomas, pleomorphic lobular carcinoma is known to be a rare histological subtype of invasive lobular carcinoma. Yet, it is more aggressive and produces a worse prognosis than other breast cancers. Ultimately, the present study compares the clinicopathological features of pleomorphic and invasive lobular breast carcinomas.

Methods

In the study, we retrospectively evaluated the data of 262 patients with histological subtypes of classical and pleomorphic lobular cancers having been recruited for surgical operations. After resorting to Kolmogorov-Smirnov and Shapiro-Wilk tests to check the normality of distribution, the categorical and continuous variables were compared between the groups using the chi-square test and independent samples t test, respectively. In all analyses, we considered a P-value of <.05 to be statistically significant.

Results

Our findings revealed that the groups with lobular and pleomorphic groups significantly differed by Ki-67 value, estrogen receptor negativity, grade, multicentricity, multifocality, surgical margin positivity, completion mastectomy, and metachronous contralateral tumor ( P < .05).

Conclusion

We discovered that pleomorphic type was associated with higher grades, estrogen receptor negativity, and Ki-67 expression. The incidence of metachronous breast cancer was high in the pleomorphic group, which may be a noteworthy finding to be considered in follow-ups. In addition, the high rates of multicentricity and multifocality of tumors in the pleomorphic group may be associated with increased surgical margin positivity and a higher likelihood of mastectomy. In a nutshell, our findings may guide patients and surgeons regarding the type of intervention and reconstruction options to be adopted in prospective surgeries.
The Soteria project recounted by Mosher and its clinical resonances today
Authors: Balbuena Rivera Francisco
Published: March 2024

Background:

The American psychiatrist Loren R. Mosher has passed to posterity as an eager proponent of a psychosocial approach to psychosis. The best example of this is the Soteria project that he founded in San Jose, California, in the 1970s. The contribution of Alma Zito Menn, ACSW, also merits attention as project director of Soteria and for her links to the Mental Research Institute, Palo Alto. She was later replaced as program director by Voyce Hendrix, LCSW, when she turned to other preoccupations linked to the grant continuation of Soteria. Equally, the nonprofessional staff of the facility should receive appreciation.

Aim/objective:

Bearing this in mind, the main aim of this paper is to reflect upon the Soteria project, giving voice to Mosher himself, while simultaneously connecting his ideas with other empirical works that have been published on this topic in recent decades.

Methods:

Using a selection from the extant literature assessing the implementation and outcomes of adapting Soteria-elements to different settings, I present here provisional results obtained from current research. First, I expound what Mosher hoped to achieve in creating Soteria and why it worked. In this respect, I go beyond what is commonly reported in scholarly works, where the Soteria project is considered without paying too great attention to its main architect, as if the project could be separated from the man who created it.

Results and conclusions:

As I have corroborated here, there is today growing and promising scientific evidence validating the principles of the Soteria project. Undoubtedly, this would not have been possible without the pioneering work of Mosher, who, imbued with the tenets of interpersonal phenomenology, shook the psychiatric establishment, leading others to follow the path that he had begun.
Aging Parents and the Ties That Bind: Intergenerational Relationship Quality Among Culturally Diverse Canadian Families
Authors: Mitchell Barbara A. , Teichman Samantha
Published: March 2024

Drawing from a life course perspective, this paper examines mid/later-life parent–child relationship quality among ethnically diverse families. Focus is on the role of culture, child, and parental characteristics. Data are drawn from a study of 588 parents aged 50+ of a least one child aged 19–35 who reside in Metro Vancouver, B.C. from four Canadian cultural groups: British, Chinese, Persian/Iranian, and South Asian. Using OLS regression methods, we use two dependent variable scales: positive and negative support/interaction appraisals of the relationship. The positive relationship quality scale is associated with South Asian versus British-Canadian parents, mothers, those with greater income satisfaction, and daughters. The negative scale is inversely associated among South Asian versus British-Canadian parents, income satisfaction, parental health, and being unpartnered (vs. partnered). Interaction effects are found between gender and ethnicity. Implications for theorizing and applied recommendations for those who work with culturally diverse aging families are discussed.
“You Don’t Want My Help?” The Negative and Positive Consequences of Help Offer Rejection
Authors: Hetrick Andrea L. , Spoelma Trevor M. , Newton Daniel W. , Romney Alexander C.
Published: March 2024

Helping is ubiquitous in organizations and vital to individual and organizational effectiveness. Yet, for various reasons, offers to help are sometimes rejected. Help offeror reactions to help offer rejection, or how employees respond to coworkers refusing their propositions to assist with work tasks, is an important but overlooked area of inquiry in organizational research. Although negative reactions to having help rejected might seem intuitive, help offer rejection may also produce positive outcomes for help offerors. Drawing upon sociometer and sensemaking theories, we present a theoretical model in which help offer rejection indirectly reduces subsequent helping through reduced organization-based self-esteem (OBSE) and indirectly increases subsequent creativity through enhanced sensemaking. We propose that the strength of these effects is moderated by coworkers’ explanation sensitivity such that coworkers’ sensitive and sincere communication reduces the negative effect on OBSE and enhances the positive effect on sensemaking. We test and find general support for this conceptual model in two multiwave, multisource field studies of full-time workers and in an experimental vignette study. We discuss the theoretical and practical implications of our findings and suggest fruitful avenues for future research.
Understanding Factorial Designs, Main Effects, and Interaction Effects: Simply Explained with a Worked Example
Authors: Andrade Chittaranjan
Published: March 2024

A factorial design examines the effects of two independent variables on a single, continuous dependent variable. The statistical test employed to analyze the data is a two-way analysis of variance (ANOVA). This test yields three results: a main effect for each of the independent variables and an interaction effect between the two independent variables. This article explains factorial designs and two-way ANOVA with the help of a worked example using hypothetical data in a spreadsheet provided as a supplementary file. The main effects and interaction effects are explained and illustrated using tables and figures. A short discussion provides general notes about the concepts explained in this article, along with brief notes on repeated measures ANOVA and higher order ANOVAs. Many additional examples, with figures and explanations, are provided in the supplementary materials, which the reader is strongly encouraged to view.
Enhancing occupational therapy education: Evaluating the impact of a STEAM-based assistive technology curriculum using Kirkpatrick’s four-level model
Authors: Hung Chia-Hui , Chen Mei-Hsiang , Fan Shih-Chen
Published: March 2024

Introduction:

Integrating assistive technology (AT) into occupational therapy (OT) education is critical to educating students to utilize AT to enhance individual independence. This study aims to describe the development of a science, technology, engineering, arts, and mathematics (STEAM)-based AT curriculum in OT and evaluate its effectiveness using the Kirkpatrick model.

Methods:

An 18-week STEAM-based AT curriculum was created with lectures, hands-on activities, and a simulation exam. A one-group pretest–posttest observational study was undertaken with 40 undergraduate students to gauge its effectiveness. Their professionalism was evaluated using a multidimensional checklist, whereas a satisfaction survey gathered their feedback on the curriculum experience.

Results:

Level 1: Participants reported high satisfaction (mean = 4.61, SD = 0.36), with a 97.5% agreement. Level 2: 95% ( n = 38) passed the AT curriculum exam. Level 3: Therapists and patients expressed satisfaction with participants’ AT skills (therapists: t(39) = 12.22, p < 0.001; patients: t(39) = 8.84, p < 0.001). Level 4: Participants showed significant improvement in professionalism ( t(39) = 16.45, p < 0.001). Lastly, using the Kirkpatrick model, the STEAM-based AT curriculum passed the evaluation.

Conclusions:

The STEAM-based AT curriculum in OT enhances professionalism and potentially boosts patient satisfaction with AT services provision.
Not so ‘dumb money’? Constituting professionals and amateurs in the history of finance capitalism
Authors: Hansen Kristian Bondo , Komporozos-Athanasiou Aris
Published: March 2024

This article examines the historically contentious relationship between the financial market and the public as discussed in academic literature, financial journalism and prescriptive how-to invest handbooks during the late 19th and early 20th centuries. Although financial markets thrive off active public participation, speculating at stock and commodity exchanges has been a sanctioned ritual reserved for a privileged minority. We argue that the financial establishment’s intent to control market access through financial entry-barriers (such as exchange membership fees and margin requirements) has been part of a bigger story we need to understand: a history of delegitimating uninitiated ‘lay speculators’ through the construction of exclusionary narratives about unfit amateur investors and morally corrupt publics. We conceptualize this process as an ongoing and delicate boundary-making exercise contributing to a market participation discourse that has been characterized by a set of reductive binaries, such as those of insider–outsider, professional–amateur and speculator–gambler. We show, however, that attempts to delineate popular participation in financial markets through these binaries have been complicated by the idea that besides being a force of market instability and collective irrationality, the public was a largely untapped source of liquidity. We argue that today’s discourse on public participation in financial markets resuscitates these simplified narratives and propose a more nuanced view of non-professional market participants being both destabilizers and liquidity-providers.
Linking Performance Appraisal and Government Employees’ Organizational Citizenship Behavior
Authors: Shim Dong Chul , Park Soonae , Park Hyun Hee
Published: March 2024

This study investigates the relationship between performance appraisal (PA) and organizational citizenship behavior (OCB) among Korean government employees, integrating social exchange theory, prosocial values, and impression management perspectives. It analyzes how employees respond to PA’s perceived effectiveness, focusing on both direct and indirect effects of PA components alongside traditional OCB antecedents. Surveying 3,336 employees, the findings indicate positive correlations between performance feedback adequacy, PA fairness, and OCB, but a negative link with PA leniency. Organizational commitment emerged as a key mediator, especially between PA leniency, performance feedback frequency, and OCB. The study emphasizes the importance of a well-structured PA system to foster employee engagement in OCB.