bluuebunny/crossref_metadata_2025 huggingface dataset:
Recommendations on multiple testing adjustment in multi-arm trials with a shared control group
Authors: Howard Dena R , Brown Julia M , Todd Susan , Gregory Walter M
Published: September 2016

Multi-arm clinical trials assessing multiple experimental treatments against a shared control group can offer efficiency advantages over independent trials through assessing an increased number of hypotheses. Published opinion is divided on the requirement for multiple testing adjustment to control the family-wise type-I error rate (FWER). The probability of a false positive error in multi-arm trials compared to equivalent independent trials is affected by the correlation between comparisons due to sharing control data. We demonstrate that this correlation in fact leads to a reduction in the FWER, therefore FWER adjustment is not recommended solely due to sharing control data. In contrast, the correlation increases the probability of multiple false positive outcomes across the hypotheses, although standard FWER adjustment methods do not control for this. A stringent critical value adjustment is proposed to maintain equivalent evidence of superiority in two correlated comparisons to that obtained within independent trials. FWER adjustment is only required if there is an increased chance of making a single claim of effectiveness by testing multiple hypotheses, not due to sharing control data. For competing experimental therapies, the correlation between comparisons can be advantageous as it eliminates bias due to the experimental therapies being compared to different control populations.
Bayesian correction for covariate measurement error: A frequentist evaluation and comparison with regression calibration
Authors: Bartlett Jonathan W , Keogh Ruth H
Published: September 2016

Bayesian approaches for handling covariate measurement error are well established and yet arguably are still relatively little used by researchers. For some this is likely due to unfamiliarity or disagreement with the Bayesian inferential paradigm. For others a contributory factor is the inability of standard statistical packages to perform such Bayesian analyses. In this paper, we first give an overview of the Bayesian approach to handling covariate measurement error, and contrast it with regression calibration, arguably the most commonly adopted approach. We then argue why the Bayesian approach has a number of statistical advantages compared to regression calibration and demonstrate that implementing the Bayesian approach is usually quite feasible for the analyst. Next, we describe the closely related maximum likelihood and multiple imputation approaches and explain why we believe the Bayesian approach to generally be preferable. We then empirically compare the frequentist properties of regression calibration and the Bayesian approach through simulation studies. The flexibility of the Bayesian approach to handle both measurement error and missing data is then illustrated through an analysis of data from the Third National Health and Nutrition Examination Survey.
Women’s Narratives about Identity, Power and Agency within a Mining Organisation in South Africa
Authors: Johnstone Leigh , Bhagwanjee Anil , Bobat Shaida
Published: September 2016

Drawing on social constructionist and post-structuralist theoretical frameworks, this study examined the complexities that constitute women’s narratives within a mining organisation in South Africa. With specific reference to the social constructs of identity, conflict and power, the aims of this study were to investigate how women narrate their experience, the ways in which women live with the tensions of a workplace that is potentially both liberating and limiting and the implications of these tensions for women’s well-being, identities and social roles. In-depth, semi-structured interviews were conducted with nine women in management positions and were analysed using an inductive emergent thematic analytical method. The nature of identity that emerged from the participants’ narratives was viewed as an act of weaving together the multiple strands of the self, where participants recognised the points at which these multiple strands intercept and where they diverge. At each point of interception and divergence there were expressions of ambiguous identity or identity salience. Identity was seen to be mediated by the micro-physics of power and, within this framework, participants were seen to be agents in negotiating an authentic and egalitarian self, and a space for women in mining.
Student Mobility in Portugal
Authors: Sin Cristina , Tavares Orlanda , Neave Guy
Published: September 2016

The article examines how far the key Bologna objective of student mobility has been achieved in Portuguese higher education institutions and the main factors shaping it. It analyzes credit mobility, outgoing and incoming, between Portugal and Europe. Although mobility overall has risen, incoming mobility has grown faster, making Portugal an importer country. Portugal’s attraction power is explained mainly by its location, climate, and leisure opportunities. For outgoing mobility, employability is the main driver, explained by high unemployment and an uncertain home labor market. The main obstacle is financial, so country choice is increasingly based on proximity and living costs. Another important constraint is curricular inflexibility of Portuguese higher education institutions. The findings suggest that mobility in Portugal is far from reflecting Bologna’s policy goals, making the 2020 mobility target of 20% an ideal rather than an achievement.
Risk Factors for and Management of Postpancreatectomy Hepatic Steatosis
Authors: Takemura N. , Saiura A. , Koga R. , Yamamoto J. , Yamaguchi T.
Published: September 2016

Background:

Relatively little is known about the risk factors and treatments for postpancreatectomy hepatic steatosis.

Methods:

The records of patients who underwent pancreaticoduodenectomy or total pancreatectomy between 2005 and 2010 and were followed up by periodic imaging were reviewed retrospectively. Risk factors and treatment for postpancreatectomy hepatic steatosis were analyzed.

Results:

A total of 253 patients were included in the analysis, including 137 males and 116 females, of median (5, 95 percentile) age 67 (47, 81) years. Of these 253 patients, 75 (29.6%) developed postpancreatectomy hepatic steatosis. Multivariable logistic regression analysis showed that female gender ( p = 0.005; odds ratio: 2.387; 95% confidence interval: 1.293–4.386), body mass index > 22.5 kg/m2 ( p = 0.007; odds ratio: 2.330; 95% confidence interval: 1.261–4.307), operative duration > 540 min ( p = 0.018; odds ratio: 2.286; 95% confidence interval: 1.153–4.533), and delayed gastric emptying ( p < 0.001; odds ratio: 4.598; 95% confidence interval: 1.979–10.678) were independent risk factors associated with postpancreatectomy hepatic steatosis. Treatment consisted of maintenance- or high-dose digestive enzyme replacement therapy. Of patients without obvious tumor recurrence after 6 months, 12 of 15 treated with high dose and only 6 of 35 treated with maintenance-dose digestive enzyme replacement therapy showed improvements in postpancreatectomy hepatic steatosis ( p = 0.006).

Conclusion:

Female gender, obesity, longer operative time, and occurrence of delayed gastric emptying are risk factors for postpancreatectomy hepatic steatosis. High-dose digestive enzyme replacement therapy may improve postpancreatectomy hepatic steatosis.
Vehicle yaw stability control using active rear steering: Development and experimental validation
Authors: Zhang Baozhen , Khajepour Amir , Goodarzi Avesta
Published: September 2016

In this paper, a novel pulse active steering system for improving vehicle yaw stability is developed. In the proposed method, pulses are sent to the steerable rear wheels whenever the error between the expected and actual yaw rate is outside a predetermined range. The proposed method and its performance are verified experimentally by full vehicle testing. For this purpose, a simplified vehicle model and a rear suspension model are developed. Vehicle stability is investigated and the steering pulse parameters on the vehicle’s stability are studied. A control system is designed and numerical simulations are performed. Moreover, the active rear steering system is implemented on a Lexus for performing road experiments. Results from simulations and experiments indicate that considerable improvement in the yaw stability performance can be achieved by the proposed system. The proposed method is more cost effective and simpler for vehicle stability control.
From Care to Custody: Trajectories of Children in Post-War New Zealand
Authors: Stanley Elizabeth
Published: September 2016

This article considers the trajectory of children from state care to imprisonment in relation to 105 New Zealanders who spent time in residential care between the 1950s and 1990s. Following previous research, the article demonstrates how children in state care are far more likely to progress into prisons as a result of maltreatment, multiple care placements, damaging residential cultures, social disadvantages and psychological harms, as well as differential treatment in the criminal justice system. This New Zealand research also shows how the interconnected and long-standing processes of victimization and criminalization increase the likelihood of a child transitioning from care to custody.
Differential effects of Pax3 on expression of polysialyltransferases STX and PST in TGF-β-treated normal murine mammary gland cells
Authors: Guo Dong , Guo Jia , Li Xiang , Guan Feng
Published: September 2016

Glycosylation of certain proteins at the mammalian cell surface is an essential event in carcinogenesis. Sialylation, one type of glycosylation, can act on multiple cell-behaviors, such as migration, growth, and malignant invasion. Two polysialyltransferases, ST8Sia II (STX) and ST8Sia IV (PST), are responsible for synthesis of polysialic acid on neural cell adhesion molecule. We showed previously that STX and PST are oppositely expressed in normal murine mammary gland cells undergoing transforming growth factor-β-induced epithelial-mesenchymal transition. The molecular basis for regulation of STX and PST remained unclear. In the present study, we observed that transcription factor Pax3 upregulates STX expression, downregulates PST expression, and modulates upregulated expression of PSA, which attaches primarily to neural cell adhesion molecule to form PSA-NCAM. Overexpression of Pax3 in normal murine mammary gland cells transformed the expression of epithelial-mesenchymal transition markers E-cadherin and N-cadherin, and significantly promoted cell migration, but had no effect on cell proliferation.
An empirical methodology for prediction of shape and flow rate of a free-falling non-submerged liquid and casting iron stream
Authors: Gamez-Montero PJ , Castilla R , Freire J , Khamashta M , Codina E
Published: September 2016

The work presented in this article demonstrates the use of an empirical and simplified approach based on an optical technique and a home-made ad hoc code that give knowledge of the shape and falling velocity of a free-falling non-submerged liquid stream to predict its typology and flow rate. The visualization photographic technique is a non-intrusive robust technique which can be applied to high-temperature liquids in harsh environments, such as an iron stream in a foundry. This technique allows predicting the liquid stream boundaries and contours without any type of treatment on the fluid. As a result of employing this empirical methodology, three flow typologies for a water stream are proposed and demonstrated experimentally. Comparisons with experimental data reveal satisfactory estimations of mean flow quantities. Finally, the approach used based on experimental visualization is carried out in an iron stream of a foundry, not being disruptive to in-situ foundry operations and showing its potential to improve performance of the cast parts’ properties during the casting phase and revealing to be a useful tool for process optimization.
Hot-Box measurements of highly insulated wall, roof and floor structures
Authors: Gullbrekken Lars , Uvslokk Sivert , Kvande Tore , Time Berit
Published: September 2016

The purpose of this study was to investigate how natural convection in air-permeable glass wool insulation affects the thermal transmittance in walls, roofs and floor structures. The results can be used to evaluate the need for a convection barrier in thick mineral wool layers. Natural convection is affected by several parameters. In this study, the angle of inclination, the heat flow direction and the temperature difference across the test section have been studied. Thermal transmittance and temperature distribution measured using thermocouples placed inside the insulation cavity clearly showed convection in the insulation when the test section was in pitched roof and wall positions. An efficient measure to reduce the natural convection is to divide the insulation layer into two thinner layers using a diffusion open convection barrier. A convection barrier is recommended by the authors both in wall and pitched roof structures if the insulation thickness exceeds 200 mm.
Education creates comfort and challenges stigma towards children with intellectual disabilities
Authors: Breau Lynn M , Aston Megan , MacLeod Emily
Published: September 2016

Children with intellectual disabilities (IDs) are frequent users of the healthcare system, yet nurses report they receive little education regarding specialized medical, social and relational needs of this population. Therefore, parents take on a greater burden of care while their child is in hospital than do parents of typically developing children. This article reports findings from a qualitative study that used feminist poststructuralism to examine the hospital experiences of eight children with IDs, 17 mothers and 12 nurses. Nurses and mothers reported a lack of knowledge and education regarding the healthcare of children with ID and identified a need for more education. Participants noted that physical care of children with ID was prioritized as more important than communication and relationships. This unintentional prioritization was socially and institutionally constructed through stigma and stereotypes about people with IDs. Nurses and parents offered suggestions to access and increase ID education for healthcare professionals.
Validation of the Crohn’s and Ulcerative Colitis questionnaire in patients with acute severe ulcerative colitis
Authors: Hutchings Hayley A , Alrubiay Laith , Watkins Alan , Cheung W‐Y , Seagrove Anne C , Williams John G
Published: September 2016

Background

The Crohn’s and Ulcerative Colitis questionnaire (CUCQ) has previously been validated in patients with mild to moderate Crohn’s and ulcerative colitis (UC). The aim of this study was to validate the tool in patients with acute severe UC.

Methods

We undertook a validation of the CUCQ in patients recruited to the COmparison of iNfliximab and ciclosporin in STeroid Resistant Ulcerative Colitis Trial (CONSTRUCT). We carried out psychometric analysis to examine the underlying dimensions of the scale, internal consistency and construct validity. We carried out stepwise regression to examine which items accounted for the greatest variance in the scale.

Results

We obtained complete data for 270 patients. The internal consistency of the CUCQ was excellent (Cronbach’s alpha > 0.8). The CUCQ scores achieved significant correlations with two generic quality of life scales (SF‐12 and EQ‐5D), demonstrating good construct validity. Stepwise regression identified 16 items that accounted for greater than 95% of the variance of the CUCQ. Only three of the eight items selected for a short form in mild to moderate patients were selected for patients with acute severe UC.

Conclusions

The CUCQ demonstrated good validity in our sample of acute severe UC patients. Stepwise regression identified potential to shorten the tool, but that different items would be selected compared with less severe patients. If the tool is to be applied across the spectrum of disease it would be more appropriate to use the full 32 items in the scale. Further work to explore test‐retest is required in acute patients.
Patent Ductus Arteriosus Banding for Circular Shunting After Pulmonary Valvuloplasty
Authors: Bautista-Rodriguez Carles , Rodriguez-Fanjul Javier , Moreno Hernando Julio , Mayol Javier , Caffarena-Calvar Jose Maria
Published: September 2016

We report two cases of newborns with critical pulmonary stenosis having intact ventricular septum, who underwent pulmonary valve balloon valvuloplasty followed by banding of a patent ductus arteriosus. Transcatheter pulmonary valvuloplasty was performed one week after delivery. Following the procedure, both developed “circular shunting” as a consequence of left-to-right ductal flow and pulmonary regurgitation. This in turn caused increased blood flow into a dysfunctional right ventricle and low systemic cardiac output syndrome. The PDA banding was performed urgently as a rescue measure in order to restore systemic flow while still maintaining some duct-dependent pulmonary blood flow. This approach resolved the circular shunting. Outcome was favorable in both the patients.
A corpus for plant-chemical relationships in the biomedical domain
Authors: Choi Wonjun , Kim Baeksoo , Cho Hyejin , Lee Doheon , Lee Hyunju
Published: September 2016

Background

Plants are natural products that humans consume in various ways including food and medicine. They have a long empirical history of treating diseases with relatively few side effects. Based on these strengths, many studies have been performed to verify the effectiveness of plants in treating diseases. It is crucial to understand the chemicals contained in plants because these chemicals can regulate activities of proteins that are key factors in causing diseases. With the accumulation of a large volume of biomedical literature in various databases such as PubMed, it is possible to automatically extract relationships between plants and chemicals in a large-scale way if we apply a text mining approach. A cornerstone of achieving this task is a corpus of relationships between plants and chemicals.

Results

In this study, we first constructed a corpus for plant and chemical entities and for the relationships between them. The corpus contains 267 plant entities, 475 chemical entities, and 1,007 plant–chemical relationships (550 and 457 positive and negative relationships, respectively), which are drawn from 377 sentences in 245 PubMed abstracts. Inter-annotator agreement scores for the corpus among three annotators were measured. The simple percent agreement scores for entities and trigger words for the relationships were 99.6 and 94.8 %, respectively, and the overall kappa score for the classification of positive and negative relationships was 79.8 %. We also developed a rule-based model to automatically extract such plant–chemical relationships. When we evaluated the rule-based model using the corpus and randomly selected biomedical articles, overall F-scores of 68.0 and 61.8 % were achieved, respectively.

Conclusion

We expect that the corpus for plant–chemical relationships will be a useful resource for enhancing plant research. The corpus is available at http://combio.gist.ac.kr/plantchemicalcorpus.
Intensity Measure Correlations Observed in the NGA-West2 Database, and Dependence of Correlations on Rupture and Site Parameters
Authors: Baker Jack W. , Bradley Brendon A.
Published: September 2016

This manuscript reports ground motion intensity measure ( IM) correlations for a number of IM types, as measured from the NGA-West2 database. IMs considered are Spectral Accelerations with periods from 0.01 s to 10 s, Peak Ground Acceleration, Peak Ground Velocity, and Significant Duration (for 5–75% and 5–95% definitions). Results are shown for correlations of both maximum-direction and geometric mean spectral acceleration values, given the need for such maximum-direction correlations in a new ASCE 7-16 procedure. Additionally, the potential magnitude-, distance- and site-condition-dependence of IM correlations are evaluated. The results are practically important as IM correlations are increasingly used in a range of engineering and seismic hazard calculations. We find that maximum-direction spectral correlations are comparable to correlations for other spectral acceleration definitions, and that the correlations have no practically significant dependence on magnitude, distance or site conditions. These results support the collective understanding that IM correlations are stable across a range of conditions, and as a result, that existing correlation models are generally appropriate for continued use in engineering calculations.
Risk of Neutropenia-Related Hospitalization in Patients Who Received Colony-Stimulating Factors With Chemotherapy for Breast Cancer
Authors: Agiro Abiy , Ma Qinli , Acheson Anupama Kurup , Wu Sze-jung , Patt Debra A. , Barron John J. , Malin Jennifer L. , Rosenberg Alan , Schilsky Richard L. , Lyman Gary H.
Published: September 2016

Purpose

To describe outcomes after granulocyte colony-stimulating factor (G-CSF) prophylaxis in patients with breast cancer who received chemotherapy regimens with low-to-intermediate risk of induction of neutropenia-related hospitalization.

Patients and Methods

We identified 8,745 patients age ≥ 18 years from a medical and pharmacy claims database for 14 commercial US health plans. This retrospective analysis included patients with breast cancer who began first-cycle chemotherapy from 2008 to 2013 using docetaxel and cyclophosphamide (TC); docetaxel, carboplatin, and trastuzumab (TCH); or doxorubicin and cyclophosphamide (conventional-dose AC) regimens. Primary prophylaxis (PP) was defined as G-CSF administration within 5 days of beginning chemotherapy. Outcome was neutropenia, fever, or infection-related hospitalization within 21 days of initiating chemotherapy. Multivariable regressions and number-needed-to-treat analyses were used.

Results

A total of 4,815 patients received TC (2,849 PP; 1,966 no PP); 2,292 patients received TCH (1,444 PP; 848 no PP); and 1,638 patients received AC (857 PP; 781 no PP) regimen. PP was associated with reduced risk of neutropenia-related hospitalization for TC (2.0% PP; 7.1% no PP; adjusted odds ratio [AOR], 0.29; 95% CI, 0.22 to 0.39) and TCH (1.3% PP; 7.1% no PP; AOR, 0.19; 95% CI, 0.12 to 0.30), but not AC (4.7% PP; 3.8% no PP; AOR, 1.21; 95% CI, 0.75 to 1.93) regimens. For the TC regimen, 20 patients (95% CI, 16 to 26) would have to be treated for 21 days to avoid one neutropenia-related hospitalization; with the TCH regimen, 18 patients (95% CI, 13 to 25) would have to be treated.

Conclusion

Primary G-CSF prophylaxis was associated with low-to-modest benefit in lowering neutropenia-related hospitalization in patients with breast cancer who received TC and TCH regimens. Further evaluation is needed to better understand which patients benefit most from G-CSF prophylaxis in this setting.
Postmastectomy Radiotherapy: An American Society of Clinical Oncology, American Society for Radiation Oncology, and Society of Surgical Oncology Focused Guideline Update
Authors: Recht Abram , Comen Elizabeth A. , Fine Richard E. , Fleming Gini F. , Hardenbergh Patricia H. , Ho Alice Y. , Hudis Clifford A. , Hwang E. Shelley , Kirshner Jeffrey J. , Morrow Monica , Salerno Kilian E. , Sledge George W. , Solin Lawrence J. , Spears Patricia A. , Whelan Timothy J. , Somerfield Mark R. , Edge Stephen B.
Published: September 2016

Purpose

A joint American Society of Clinical Oncology, American Society for Radiation Oncology, and Society of Surgical Oncology panel convened to develop a focused update of the American Society of Clinical Oncology guideline concerning use of postmastectomy radiotherapy (PMRT).

Methods

A recent systematic literature review by Cancer Care Ontario provided the primary evidentiary basis. The joint panel also reviewed targeted literature searches to identify new, potentially practice-changing data.

Recommendations

The panel unanimously agreed that available evidence shows that PMRT reduces the risks of locoregional failure (LRF), any recurrence, and breast cancer mortality for patients with T1-2 breast cancer with one to three positive axillary nodes. However, some subsets of these patients are likely to have such a low risk of LRF that the absolute benefit of PMRT is outweighed by its potential toxicities. In addition, the acceptable ratio of benefit to toxicity varies among patients and physicians. Thus, the decision to recommend PMRT requires a great deal of clinical judgment. The panel agreed clinicians making such recommendations for individual patients should consider factors that may decrease the risk of LRF, attenuate the benefit of reduced breast cancer–specific mortality, and/or increase risk of complications resulting from PMRT. When clinicians and patients elect to omit axillary dissection after a positive sentinel node biopsy, the panel recommends that these patients receive PMRT only if there is already sufficient information to justify its use without needing to know additional axillary nodes are involved. Patients with axillary nodal involvement after neoadjuvant systemic therapy should receive PMRT. The panel recommends treatment generally be administered to both the internal mammary nodes and the supraclavicular-axillary apical nodes in addition to the chest wall or reconstructed breast.
Team Cognition As a Means to Improve Care Delivery in Critically Ill Patients With Cancer After Hematopoietic Cell Transplantation
Authors: McNeese Nathan J. , Khera Nandita , Wordingham Sara E. , Arring Noel , Nyquist Sharon , Gentry Amy , Tomlinson Brian , Cooke Nancy J. , Sen Ayan
Published: September 2016

Hematopoietic cell transplantation (HCT) is an important and complex treatment modality for a variety of hematologic malignancies and some solid tumors. Although outcomes of patients who have undergone HCT and require care in intensive care units (ICUs) have improved over time, mortality rates remain high and there are significant associated costs. Lack of a team-based approach to care, especially during critical illness, is detrimental to patient autonomy and satisfaction, and to team morale, ultimately leading to poor quality of care. In this manuscript, we describe the case of a patient who had undergone HCT and was in the ICU setting, where inconsistent team interaction among the various stakeholders delivering care resulted in a lack of shared goals and poor outcomes. Team cognition is cognitive processing at the team level through interactions among team members and is reflected in dynamic communication and coordination behaviors. Although the patient received multidisciplinary care as needed in a medically complicated case, a lack of team cognition and, particularly, inconsistent communication among the dynamic teams caring for the patient, led to mixed messages being delivered with high-cost implications for the health-care system and the family. This article highlights concepts and recommendations that begin a necessary in-depth assessment of implications for clinical care and initiate a research agenda that examines the effects of team cognition on HCT teams, and, more generally, critical care of the patient with cancer.
Improving the Transition From Oncology to Primary Care Teams: A Case for Shared Leadership
Authors: Tremblay Dominique , Latreille Jean , Bilodeau Karine , Samson Arnaud , Roy Linda , L’Italien Marie-France , Mimeault Christine
Published: September 2016

This article discusses the case of a 47-year-old woman who underwent primary therapy with curative intent for breast cancer. The case illustrates a number of failure events in transferring information and responsibility from oncology to primary care teams. The article emphasizes the importance of shared leadership, as multiple team members, dispersed in time and space, pursue their own objectives while achieving the common goal of coordinating care for survivors of cancer transitioning across settings. Shared leadership is defined as a team property comprising shared responsibility and mutual influence between the patient and the patient’s family, primary care providers, and oncology teams, whereby they lead each other toward quality and safety of care. Teams, including the patient-family, should achieve leadership when their contribution is relevant in managing task interdependence during transition. Shared leadership fosters coordinated actions to enable functioning as an integrated team-of-teams. This article illustrates how shared leadership can make a difference to coordinate interfaces and pathways, from therapy with curative intent to the follow-up and management of survivors of breast cancer. The detailed case is elaborated as a clinical vignette. It can be used by care providers and researchers to consider the need for new models of care for survivors of cancer by addressing the following questions. Who accepts shared leadership, how, with whom, and under what conditions? What is the evidence that supports the answers to these questions? The detailed case is also valuable for medical and allied health professional education.
Smart Mechanical Dipole: a device for the measurement of sphere motion in behavioral and neurophysiological experiments
Authors: Herzog Hendrik , Mogdans Joachim , Bleckmann Horst
Published: September 2016

Fluid motion and pressure fields induced by vibrating spheres are frequently used to investigate the function of biological mechanosensory systems and artificial sensors. The calibration of the sphere motion amplitude (displacement, velocity, acceleration), time course and vibration direction often demands expensive equipment. To mitigate this requirement, we have developed a high-quality, low-cost device that we term a ‘Smart Mechanical Dipole’. It provides real-time measurement of sphere acceleration along three axes and can be used to obtain an accurate stimulation trace. We applied digital filtering to equalize the frequency response of the vibrating sphere, which also reduced unwanted amplitude and frequency changes in the hydrodynamic signal. In addition, we show that the angular orientation of the rod to which the sphere was attached, i.e. axial versus transverse, but not the immersion depth of the sphere affected sphere vibration behavior.
Δ. Φιλιππίδης: Αλληλογραφία 1794-1819
Authors: Κουμαριανού Αικατερίνη
Published: September 2016

No abstract
Και το έντυπο
Authors: Δημαράς Κ. Θ.
Published: September 2016

No abstract
Παλαιά έντυπα και χειρόγραφα στη Ρουμανία
Authors: Δρούλια Λουκία
Published: September 2016

No abstract
Henri Berr
Authors: Dimaras C. Th.
Published: September 2016

No abstract
Nicolas Iorga
Authors: Dimaras C. Th.
Published: September 2016

No abstract
Τρεις «γραμματικοί» του Σολωμού
Authors: Coutelle Louis
Published: September 2016

No abstract
Ελληνική Βιβλιογραφία 1800-1863. Προσθήκες
Authors: Σαμπανόπουλος Βασ.
Published: September 2016

No abstract
Ψαλτήριον του έτους 1588
Authors: Κομίνης Αθανάσιος Δ.
Published: September 2016

No abstract
J. D. Carlyle's Journal of Mount Athos (1801)
Authors: Anghelou Alkis
Published: September 2016

No abstract
Το «Υπόμνημα περί της παρούσης καταστάσεως του Πολιτισμού εν Ελλάδι» του Α. Κοραή και οι δύο πρώτες εκδόσεις του
Authors: Χατζηδήμος Αθ.
Published: September 2016

No abstract
Αρχείο Μονής Ιωάννου Θεολόγου Πάτμου (Ταξινόμηση και φωτογράφηση)
Authors: Παναγιωτόπουλος Β. Π.
Published: September 2016

No abstract
Ο Κοραής και η Ιονική Ακαδημία (1808-1814)
Authors: Φραγκίσκος Εμμ. Ν.
Published: September 2016

No abstract
Ελληνική Βιβλιογραφία 1800-1863. Προσθήκες
Authors: Χατζηδήμος Α. , Σίμος Γ.
Published: September 2016

No abstract
Ένα σχέδιο του Ι. Ρώτα για την έκδοση των επιστολών του Κοραή
Authors: Αγγέλου Άλκης
Published: September 2016

No abstract
Η βιβλιοθήκη του Θεόφιλου Καμπανίας (Ο πνευματικός κόσμος ενός φιλελεύθερου Δεσπότη)
Authors: Γκίνης Δημήτριος Σ.
Published: September 2016

No abstract
Στίχοι του Σολωμού και άλλα κείμενα σχετικά
Authors: Δημαράς Κ. Θ.
Published: September 2016

No abstract
Μαρτυρίες για τον Σολωμό (Δύο ανέκδοτα γράμματα του Κων. Τυπάλδου)
Authors: Μουλλάς Παν.
Published: September 2016

No abstract
Περίανδρος Φιλίππου
Authors: Παναγιωτόπουλος Β. Π.
Published: September 2016

No abstract
Ελληνική Βιβλιογραφία 1800-1863. Προσθήκες
Authors: Φραγκίσκος Εμμ. Ν.
Published: September 2016

No abstract
Η φιλία Κοραή – Villoison και τα προβλήματά της
Authors: Φραγκίσκος Εμμ. Ν.
Published: September 2016

No abstract
Λανθάνουσα «Γεωγραφία» των αρχών του ΙΗ' αι.
Authors: Κομίνης Αθ.
Published: September 2016

No abstract
Alexandre Mavrocordato, Machiavel et La Rochefoucauld. Notes de lecture
Authors: Dimaras C. Th.
Published: September 2016

No abstract
Sulle fonti dell' Assedio di Malta di Antonio Achelis
Authors: Spadaro Giuseppe
Published: September 2016

No abstract
Επιδράσεις του Ariosto στον Ερωτόκριτο. Ο Tasso άγνωστος στον Κορνάρο
Authors: Spadaro Giuseppe
Published: September 2016

No abstract
Gennadeion Gleanings
Authors: Walton Francis R.
Published: September 2016

No abstract
Aadu Musta tööde valikbibliograafia
Authors: Taal Kersti
Published: September 2016

Aadu Musta tööde valikbibliograafia.
Regulatory impediments to the implementation of a community paramedicine programme in Virginia
Authors: Neiman Gregory S , Hertelendy Attila J
Published: September 2016

The growth of community paramedicine-mobile integrated health-care programmes has increased steadily across the United States since the term was first used in print in the United States by Kevin McGinnis in 2001. Unfortunately, the basic definitions of Emergency Medical Services as well as regulations in Virginia may block full implementation of this program, unless they can be changed. Yet one program in Chesterfield County has found a way to start successfully, despite these challenges.
Signs and symptoms of breast cancer: The practice nurse role
Authors: Harmer Victoria
Published: September 2016

Breast cancer is the most common cancer in the UK. Victoria Harmer illustrates the role practice nurses can play in promoting breast awareness and the NHS breast screening programme in consultations

This article will describe the principles of being breast aware, signs, symptoms and risk factors of breast cancer, and the National Health Service breast screening programme (NHSBSP). The article aims to illustrate that practice nurses are in a privileged and unique position to promote these aspects with the hope this will empower patients as they take more responsibility for their health.
Effective computing CPD
Authors: Dorling Mark
Published: September 2016

The introduction of the computing curriculum has proved challenging for schools. Mark Dorling looks at what CPD is available and urges school leaders to prioritise teacher support and development
Hospitalized Children and Opportunities to Vaccinate Vulnerable Populations: An Integrative Literature Review
Authors: BejoWolkers Paula Carolina , Santos Jaqueline Silva , Carvalho Furtado Maria Cândida de , Pina Juliana Coelho , Garcia Lima Regina Aparecida , De Mello Débora Falleiros
Published: September 2016

The present study aimed to identify evidence available in the health literature concerning the immunization of hospitalized children. This is a descriptive study based on an integrative literature review. Nine scientific papers published between 2001 and 2013 were analyzed. The results were organized into three themes: opportunities to vaccinate hospitalized children; factors against immunizing hospitalized children; and strategies and interventions to improve child vaccination coverage. Hospitalization is an opportunity to identify factors related to why parents do not vaccinate their children and then implement strategies, such as educational interventions, records-updating, immunization reminders, and providing guidance after hospital discharge.
Decreasing pelvic incidence is associated with greater risk of cam morphology
Authors: Morris W. Z. , Fowers C. A. , Yuh R. T. , Gebhart J. J. , Salata M. J. , Liu R. W.
Published: September 2016

Objectives

The spinopelvic relationship (including pelvic incidence) has been shown to influence pelvic orientation, but its potential association with femoroacetabular impingement has not been thoroughly explored. The purpose of this study was to prove the hypothesis that decreasing pelvic incidence is associated with increased risk of cam morphology.

Methods

Two matching cohorts were created from a collection of cadaveric specimens with known pelvic incidences: 50 subjects with the highest pelvic incidence (all subjects > 60°) and 50 subjects with the lowest pelvic incidence (all subjects < 35°). Femoral version, acetabular version, and alpha angles were directly measured from each specimen bilaterally. Cam morphology was defined as alpha angle > 55°. Differences between the two cohorts were analysed with a Student’s t-test and the difference in incidence of cam morphology was assessed using a chi-squared test. The significance level for all tests was set at p < 0.05.

Results

Cam morphology was identified in 47/100 (47%) femurs in the cohort with pelvic incidence < 35° and in only 25/100 (25%) femurs in the cohort with pelvic incidence > 60° (p = 0.002). The mean alpha angle was also greater in the cohort with pelvic incidence < 35° (mean 53.7°, sd 10.7° versus mean 49.7°, sd 10.6°; p = 0.008).

Conclusions

Decreased pelvic incidence is associated with development of cam morphology. We propose a novel theory wherein subjects with decreased pelvic incidence compensate during gait (to maintain optimal sagittal balance) through anterior pelvic tilt, creating artificial anterior acetabular overcoverage and recurrent impingement that increases risk for cam morphology. Cite this article: W. Z. Morris, C. A. Fowers, R. T. Yuh, J. J. Gebhart, M. J. Salata, R. W. Liu. Decreasing pelvic incidence is associated with greater risk of cam morphology. Bone Joint Res 2016;5:387–392. DOI: 10.1302/2046-3758.59.BJR-2016-0028.R1.
A PRACTICAL IMPLEMENTATION OF INTERVAL ARITHMETIC IN AHP
Authors: Hadiono Kristophorus
Published: September 2016

One of the well-established methods that help the decision makers deal with multiple criteria is the Analytical Hierarchy Process (AHP) which utilizes a weighting approach. The process of decision making with multiple criteria is faster if all the weights of the factors related to a particular problem are clearly stated. However, if the weights of said factors are not well defined, or only their lower and upper weight limits are known, then the decision makers face considerable uncertainty because the standard AHP numerical procedure operates with deterministic values. As a result, the corresponding assessment preferences cannot be expressed in the form of a sequence of numerical values and implemented in the AHP evaluation. A practical approach is presented in this work to deal with the data uncertainty by implementing interval arithmetic in the AHP calculations so that the assessment preferences are presented in the form of interval numbers.
IDENTIFYING THE MOST SUITABLE SUSTAINABLE ENERGY SYSTEM FOR NEPAL USING ANALYTIC HIERARCHY PROCESS
Authors: Sapkota Prabal , Pokharel Martina , Pandey Madhav Prasad
Published: September 2016

The issue of climate change and energy crisis can be resolved by the advancement of sustainable energy systems. The process of energy development in developing countries with a poor economy is complicated. One has to consider numerous factors and sub-factors which are important for the system to be acceptable to the multiple stakeholders. Involvement of multiple entities makes the process a real case of Multi Criteria Decision Making (MCDM). This study deals with identification of various stakeholders, factors, sub-factors and alternatives associated with sustainable energy selection in Nepal. The Analytic Hierarchy Process (AHP) has been used as a tool to deal with the MCDM problem in this research. Prioritization of alternatives has been obtained with the application of AHP. Further, the analysis has also been done based on the perception of multiple stakeholder groups. The result shows that politicians are the most important (61%) among the stakeholders for the development of sustainable energy in Nepal. Among the alternatives, the majority of the respondents believe that biogas should be given the highest priority.
Policy failures, policy learning and institutional change: the case of Australian health insurance policy change
Authors: Kay Adrian
Published: September 2016

This article presents an institutionalist perspective on the relationship between policy failure and policy learning. It contributes both to our understanding of different patterns institutional change as well as the conditions for policy learning at the system-wide level. The first section elaborates the concept of policy failure in terms of type, value and timing. Next, how policy failure may trigger a process of deinstitutionalisation and in turn create conditions for subsequent policy learning is described. These contributions to theory are explored through selected evidence from the reform trajectory of Australian health insurance policy from the mid-1970s to late-1990s.
A concrete realization of the slow-fast alternative for a semilinear heat equation with homogeneous Neumann boundary conditions
Authors: Ghisi Marina , Gobbino Massimo , Haraux Alain
Published: September 2016

We investigate the asymptotic behavior of solutions to a
semilinear heat equation with homogeneous Neumann boundary
conditions.
It was recently shown that the nontrivial kernel of the linear
part leads to the coexistence of fast solutions decaying to 0
exponentially (as time goes to infinity), and slow solutions
decaying to 0 as negative powers of t.
Here we provide a characterization of slow/fast solutions in terms
of their sign, and we show that the set of initial data giving
rise to fast solutions is a graph of codimension one in the phase
space.
Crime in Lithuanian Cities in Relation to Urban Planning and Design Aspects
Authors: Matijošaitienė Irina , Gedvilaite Monika
Published: September 2016

Crime is a social phenomenon, which is closely related to human behaviour, economics, urban planning and design. The detailed research of six blocks of houses in three Lithuanian cities (Kaunas, Vilnius and Panevezys) with the highest crime rates and the most heterogeneous crimes was performed. Space syntax method, crime prevention through environmental design (CPTED) and correlation analysis were applied. Research results demonstrate that thefts from cars, other thefts, crime against human health, robberies, small-scale hooliganism and intentional damage or destruction of property correlate with particular properties of urban spaces and design elements.
Design-Build Concept In Architectural Education
Authors: Folić Branislav , Kosanović Saja , Glažar Tadej , Fikfak Alenka
Published: September 2016

Design studio, workshop, practical placement and design-build concept, are all forms of experiential learning. The aim of this paper is to investigate the significance of design-build concept and to define the extent to which it has penetrated into architectural curricula. Results indicate variety in understanding, programming and implementation among different schools. Conducted comparative analysis of different case examples could be used as a guideline to schools in which this concept has not been introduced yet.
从虚词变异看马来西亚华语与早期现代汉语的关系
Authors: 彩云 王
Published: September 2016

马来西亚华语通常被认为是以现代汉语普通话为核心的马来西亚华人共同语。本文对 “从” “把” “和” “不但” “既然” 等虚词的变异进行研究，发现搭配成分异常，连接成分不同，使用的冗余、缺省，连用成分的异常，与其他词语的混用等是变异的主要表现，这些表现在早期现代汉语中可以找到踪迹。分析马来西亚华语的形成过程，认为对早期现代汉语语法特点的继承是导致变异产生的主要原因。马来西亚华语与早期现代汉语语法上具有继承关系。
Tracing ethnic socialisation of Chinese in Malaysia to Chinese-medium school
Authors: Phooi-Yan Lee Diana , Ting Su-Hie
Published: September 2016

The study examined the ethnic socialisation by comparing the influences of the family and school on the development of ethnic identity. The participants were 397 Malaysians of Chinese descent with Malay, Chinese and English educational backgrounds. Familial ethnic socialisation was moderate and similar for the three groups. They were similar in the resolution and affirmation dimensions of their ethnic identity. The role of Chinese-medium school in ethnic socialisation is evident in the greater exploration of ethnicity by the Chinese-educated participants. This group also valued Chinese-medium education and the Chinese language, Chinese name and Chinese festivals as markers of Chinese identity. However, the other two groups did not believe in marking their Chinese identity. Considering that ethnicised identity is a given in Malaysia, the findings suggest that the Chinese who did not have Chinese educational background may be migrating from Chinese ethnicity to notion of the Malaysian race (Bangsa Malaysia).
Pokemon decreases the transcriptional activity of RARα in the absence of ligand
Authors: Yang Yutao , Li Yueting , Di Fei , Cui Jiajun , Wang Yue , David Xu Zhi-Qing
Published: September 2016

Pokemon is a transcriptional repressor that belongs to the POZ and Krüppel (POK) protein family. In this study, we investigated the potential interaction between Pokemon and retinoic acid receptor alpha (RARα) and determined the role of Pokemon in regulation of RARα transcriptional activity in the absence of ligand. We found that Pokemon could directly interact with RARα. Moreover, we demonstrated that Pokemon could decrease the transcriptional activity of RARα in the absence of ligand. Furthermore, we showed that Pokemon could repress the transcriptional activity of RARα by increasing the recruitment of nuclear receptor co-repressor (NCoR) and silencing mediator of retinoic acid and thyroid hormone receptor (SMRT) to the retinoic acid response element (RARE) element. Taken together, these data suggest that Pokemon is a novel partner of RARα that acts as a co-repressor to regulate RARα transcriptional activity in the absence of ligand.
A Hybrid Method for Evaluating of Lightning Performance of Overhead Lines based on Monte Carlo Procedure
Authors: Shariatinasab Reza , Tadayon Pooya , Ametani Akihiro
Published: September 2016

This paper proposes a hybrid method for calculating lightning performance of overhead lines caused by direct strokes by combining Lattice diagram together with the Monte Carlo method. In order to go through this, firstly, the proper analytical relations for overvoltages calculation are established based on Lattice diagram. Then, the Monte Carlo procedure is applied to the obtained analytical relations. The aim of the presented method that will be called ‘ML method’ is simply estimation of the lightning performance of the overhead lines and performing the risk analysis of power apparatus with retaining the acceptable accuracy. To confirm the accuracy, the calculated results of the presented ML method are compared with those calculated by the EMTP/ATP simulation.
Adaptive Testing for Nondestructive Evaluation of Degraded Materials
Authors: Tomáš Ivan , Vértesy Gábor
Published: September 2016

Method of Adaptive testing (AT) is described, as a way of optimization of experimental evaluation of degraded materials, which are measured nondestructively, indirectly via a convenient physical process. The general AT is illustrated by a well-explored special case of magnetic adaptive testing (MAT) of strained steel. Degradation curves obtained from AT are regularly more sensitive and experimentally friendly than traditional descriptors of the used physical process itself. Any of the traditional descriptors of the physical process, being optimized for description of the process itself, is very probably not optimized for description of the investigated material degradation.