bluuebunny/crossref_metadata_2025 huggingface dataset:
Identification and analysis of brown planthopper-responsive microRNAs in resistant and susceptible rice plants
Authors: Wu Yan , Lv Wentang , Hu Liang , Rao Weiwei , Zeng Ya , Zhu Lili , He Yuqing , He Guangcun
Published: August 2017

The brown planthopper (BPH) is the most devastating insect pest of rice. The rice gene BPH15 confers resistance to BPH. MicroRNAs (miRNAs) regulate a spectrum of development and defense response processes in plants. In this study, we analyzed six miRNA profiles of a BPH15 introgression line (P15) and a susceptible recipient line (PC) at three time points (0 h, 6 h and 48 h) after BPH attack, and identified 464 known miRNAs and 183 potential novel miRNAs. Before the BPH feeding, we identified 23 miRNAs differentially expressed in P15 and PC. We speculated that the resistant plant is in a priming state by the regulation of miRNAs. After the BPH feeding, 104 miRNAs were found to be expressed differentially in P15 (68 in P15-6/P15-0, 36 in P15-48/P15-0), and 80 miRNAs were found expressed differentially in PC (32 in PC-6/PC-0, 48 in PC-48/PC-0), which illustrated that miRNA expression is activated upon attack. These miRNAs regulate different pathways that contribute to the basal defense and specific resistance of rice to the BPH. Our study provides additional data for scientists to further explore the mechanism of plant defense against insect attack and to find a way for efficient insect control.
NOS2-deficient mice with hypoxic necrotizing lung lesions predict outcomes of tuberculosis chemotherapy in humans
Authors: Gengenbacher Martin , Duque-Correa Maria A. , Kaiser Peggy , Schuerer Stefanie , Lazar Doris , Zedler Ulrike , Reece Stephen T. , Nayyar Amit , Cole Stewart T. , Makarov Vadim , Barry III Clifton E. , Dartois Véronique , Kaufmann Stefan H. E.
Published: August 2017

During active TB in humans a spectrum of pulmonary granulomas with central necrosis and hypoxia exists. BALB/c mice, predominantly used in TB drug development, do not reproduce this complex pathology thereby inaccurately predicting clinical outcome. We found that Nos2−/− mice incapable of NO-production in immune cells as microbial defence uniformly develop hypoxic necrotizing lung lesions, widely observed in human TB. To study the impact of hypoxic necrosis on the efficacy of antimycobacterials and drug candidates, we subjected Nos2−/− mice with TB to monotherapy before or after establishment of human-like pathology. Isoniazid induced a drug-tolerant persister population only when necrotic lesions were present. Rifapentine was more potent than rifampin prior to development of human-like pathology and equally potent thereafter, in agreement with recent clinical trials. Pretomanid, delamanid and the pre-clinical candidate BTZ043 were bactericidal independent of pulmonary pathology. Linezolid was bacteriostatic in TB-infected Nos2−/− mice but significantly improved lung pathology. Hypoxic necrotizing lesions rendered moxifloxacin less active. In conclusion, Nos2−/− mice are a predictive TB drug development tool owing to their consistent development of human-like pathology.
Searching for signatures across microbial communities: Metagenomic analysis of soil samples from mangrove and other ecosystems
Authors: Imchen Madangchanok , Kumavath Ranjith , Barh Debmalya , Azevedo Vasco , Ghosh Preetam , Viana Marcus , Wattam Alice R.
Published: August 2017

In this study, we categorize the microbial community in mangrove sediment samples from four different locations within a vast mangrove system in Kerala, India. We compared this data to other samples taken from the other known mangrove data, a tropical rainforest, and ocean sediment. An examination of the microbial communities from a large mangrove forest that stretches across southwestern India showed strong similarities across the higher taxonomic levels. When ocean sediment and a single isolate from a tropical rain forest were included in the analysis, a strong pattern emerged with Bacteria from the phylum Proteobacteria being the prominent taxon among the forest samples. The ocean samples were predominantly Archaea, with Euryarchaeota as the dominant phylum. Principal component and functional analyses grouped the samples isolated from forests, including those from disparate mangrove forests and the tropical rain forest, from the ocean. Our findings show similar patterns in samples were isolated from forests, and these were distinct from the ocean sediment isolates. The taxonomic structure was maintained to the level of class, and functional analysis of the genes present also displayed these similarities. Our report for the first time shows the richness of microbial diversity in the Kerala coast and its differences with tropical rain forest and ocean microbiome.
Impact of varying social experiences during life history on behaviour, gene expression, and vasopressin receptor gene methylation in mice
Authors: Bodden Carina , van den Hove Daniel , Lesch Klaus-Peter , Sachser Norbert
Published: August 2017

Both negative and positive social experiences during sensitive life phases profoundly shape brain and behaviour. Current research is therefore increasingly focusing on mechanisms mediating the interaction between varying life experiences and the epigenome. Here, male mice grew up under either adverse or beneficial conditions until adulthood, when they were subdivided into groups exposed to situations that either matched or mismatched previous conditions. It was investigated whether the resulting four life histories were associated with changes in anxiety-like behaviour, gene expression of selected genes involved in anxiety and stress circuits, and arginine vasopressin receptor 1a (Avpr1a) gene methylation. Varying experiences during life significantly modulated (1) anxiety-like behaviour; (2) hippocampal gene expression ofAvpr1a, serotonin receptor 1a (Htr1a), monoamine oxidase A (Maoa), myelin basic protein (Mbp), glucocorticoid receptor (Nr3c1), growth hormone (Gh); and (3) hippocampal DNA methylation within theAvpr1agene. Notably, mice experiencing early beneficial and later adverse conditions showed a most pronounced downregulation ofAvpr1aexpression, accompanied by low anxiety-like behaviour. This decrease inAvpr1aexpression may have been, in part, a consequence of increased methylation in theAvpr1agene. In summary, this study highlights the impact of interactive social experiences throughout life on the hippocampal epigenotype and associated behaviour.
Disease-syndrome combination modeling: metabolomic strategy for the pathogenesis of chronic kidney disease
Authors: Li Shasha , Xu Peng , Han Ling , Mao Wei , Wang Yiming , Luo Guoan , Yang Nizhi
Published: August 2017

Conventional disease animal models have limitations on the conformity to the actual clinical situation. Disease-syndrome combination (DS) modeling may provide a more efficient strategy for biomedicine research. Disease model and DS model of renal fibrosis in chronic kidney disease were established by ligating the left ureter and by ligating unilateral ureteral combined with exhaustive swimming, respectively. Serum metabolomics was conducted to evaluate disease model and DS model by using ultra performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry. Potential endogenous biomarkers were identified by multivariate statistical analysis. There are no differences between two models regarding their clinical biochemistry and kidney histopathology, while metabolomics highlights their difference. It is found that abnormal sphingolipid metabolism is a common characteristic of both models, while arachidonic acid metabolism, linolenic acid metabolism and glycerophospholipid metabolism are highlighted in DS model. Metabolomics is a promising approach to evaluate experiment animal models. DS model are comparatively in more coincidence with clinical settings, and is superior to single disease model for the biomedicine research.
Dietary factors and polymorphisms in vitamin D metabolism genes: the risk and prognosis of colorectal cancer in northeast China
Authors: Gong Chen , Long Zhiping , Yu Yanming , Zhu Lin , Tian Jingshen , Li Shuo , Li Jing , Yu Hongyuan , Chi Qiang , Piao Daxun , Wang Fan , Zhao Yashuang , Cui Binbin
Published: August 2017

CYP24A1 and CYP27B1 are critical genes determining 1α,25(OH)2D3 concentration and impacting on carcinogenesis. A case–control study including 528 colorectal cancer (CRC) patients and 605 cancer-free controls and a follow-up study with 317 cases were conducted in northeast China. Genotypes were tested by TaqMan Genotyping Assays. Individuals carrying the GG genotype of CYP27B1 G > T (rs10877012) exhibited decreased CRC risk compared with those with the TT genotype (ORadjusted (ORadj) = 0.57, 95% Confidence Interval (CI) = 0.38–0.84). Compared with the TT genotype, a significant association between the CC genotype of CYP27B1 C > T (rs4646536) and a reduced risk of CRC was observed (ORadj = 0.59, 95% CI = 0.40–0.88). We also observed significant combined effects of the two polymorphisms in CYP27B1 with dietary factors, including the intake of cereals, overnight meal, allium vegetables, pork, canned fruit, and braised fish, on CRC risk. These associations remained significant after Bonferroni correction for multiple comparisons. The Hazard Ration (HR) of patients with the AA genotype (CYP24A1 A > G, rs4809957) was 2.38 (95% CI = 1.30–4.37) when compared with the GG genotype. Thus, our findings suggested that two polymorphisms in CYP27B1 are associated with CRC susceptibility. CYP24A1 A > G (rs4809957) polymorphism may lead to a worse prognosis of CRC.
Antiviral properties of resveratrol against pseudorabies virus are associated with the inhibition of IκB kinase activation
Authors: Zhao Xinghong , Cui Qiankun , Fu Qiuting , Song Xu , Jia Renyong , Yang Yi , Zou Yuanfeng , Li Lixia , He Changliang , Liang Xiaoxia , Yin Lizi , Lin Juchun , Ye Gang , Shu Gang , Zhao Ling , Shi Fei , Lv Cheng , Yin Zhongqiong
Published: August 2017

Pseudorabies virus (PRV) is a pathogen of swine resulting in devastating disease and economic losses worldwide. Resveratrol (Res) exhibits inhibitory activity against a wide range of viruses. Despite these important advances, the molecular mechanism(s) by which Res exerts its broad biological effects have not yet been elucidated. In this paper, the antiviral activity of Res against PRV and its mechanism of action were investigated. The results showed that Res potently inhibited PRV replication in a dose-dependent manner, with a 50% inhibition concentration of 17.17 μM. The inhibition of virus multiplication in the presence of Res was not attributed to direct inactivation or inhibition of viral entry into the host cells but to the inhibition of viral multiplication in host cells. Further studies demonstrated that Res is a potent inhibitor of both NF-κB activation and NF-κB-dependent gene expression through its ability to inhibit IκB kinase activity, which is the key regulator in NF-κB activation. Thus, the inhibitory effect of Res on PRV-induced cell death and gene expression may be due to its ability to inhibit the degradation of IκB kinase. These results provided a new alternative control measure for PRV infection and new insights into the antiviral mechanism of Res.
Development of enhanced ethanol ablation as an alternative to surgery in treatment of superficial solid tumors
Authors: Morhard Robert , Nief Corrine , Barrero Castedo Carlos , Hu Fangyao , Madonna Megan , Mueller Jenna L. , Dewhirst Mark W. , Katz David F. , Ramanujam Nirmala
Published: August 2017

While surgery is at the foundation of cancer treatment, its access is limited in low-income countries. Here, we describe development of a low-cost alternative therapy based on intratumoral ethanol injection suitable for resource-limited settings. Although ethanol-based tumor ablation is successful in treating hepatocellular carcinomas, the necessity for multiple treatments, injection of large fluid volumes, and decreased efficacy in treatment of non-capsulated tumors limit its applicability. To address these limitations, we investigated an enhanced ethanol ablation strategy to retain ethanol within the tumor through the addition of ethyl cellulose. This increases the viscosity of injected ethanol and forms an ethanol-based gel-phase upon exposure to the aqueous tumor environment. This technique was first optimized to maximize distribution volume, using tissue-simulating phantoms. Then, chemically-induced epithelial tumors in the hamster cheek pouch were treated. As controls, pure ethanol injections of either four times or one-fourth the tumor volume induced complete regression of 33% and 0% of tumors, respectively. In contrast, ethyl cellulose-ethanol injections of one-fourth the tumor volume induced complete regression in 100% of tumors. These results contribute to proof-of-concept for enhanced ethanol ablation as a novel and effective alternative to surgery for tumor treatment, with relevance to resource-limited settings.
Fluticasone/salmeterol reduces remodelling and neutrophilic inflammation in severe equine asthma
Authors: Bullone Michela , Vargas Amandine , Elce Yvonne , Martin James G. , Lavoie Jean-Pierre
Published: August 2017

Asthmatic airways are inflamed and undergo remodelling. Inhaled corticosteroids and long-acting β2-agonist combinations are more effective than inhaled corticosteroid monotherapy in controlling disease exacerbations, but their effect on airway remodelling and inflammation remains ill-defined. This study evaluates the contribution of inhaled fluticasone and salmeterol, alone or combined, to the reversal of bronchial remodelling and inflammation. Severely asthmatic horses (6 horses/group) were treated with fluticasone, salmeterol, fluticasone/salmeterol, or with antigen avoidance for 12 weeks. Lung function, central and peripheral airway remodelling, and bronchoalveolar inflammation were assessed. Fluticasone/salmeterol and fluticasone monotherapy decreased peripheral airway smooth muscle remodelling after 12 weeks (p = 0.007 and p = 0.02, respectively). On average, a 30% decrease was observed with both treatments. In central airways, fluticasone/salmeterol reversed extracellular matrix remodelling after 12 weeks, both within the lamina propria (decreased thickness, p = 0.005) and within the smooth muscle layer (p = 0.004). Only fluticasone/salmeterol decreased bronchoalveolar neutrophilia (p = 0.03) to the same extent as antigen avoidance already after 8 weeks. In conclusion, this study shows that fluticasone/salmeterol combination decreases extracellular matrix remodelling in central airways and intraluminal neutrophilia. Fluticasone/salmeterol and fluticasone monotherapy equally reverse peripheral airway smooth muscle remodelling.
MicroRNAs 218a-5p, 219a-5p, and 221-3p regulate vestibular compensation
Authors: Chang Mun Young , Park Sohyeon , Choi Jun Jae , Kim Young-Kook , Suh Myung-Whan , Lee Jun Ho , Oh Seung Ha , Park Moo Kyun
Published: August 2017

Unilateral vestibular deafferentation (UVD) interrupts afferent signals from one side, resulting in an imbalance of the resting activity between bilateral vestibular nuclei. Vestibular compensation is the process of balancing the resting activity to reestablish homeostasis. Here, we investigated microRNAs (miRNAs) that regulate vestibular compensation using the Sprague–Dawley rat. After determining the progression of vestibular compensation following UVD, microarray analysis was performed and nine miRNAs were selected as candidates. Following validation by quantitative reverse transcription-PCR, three miRNAs remained. We assessed the effect of these miRNAs on vestibular compensation using miRNA oligomers. We compared the results of the rotarod test and 5-bromo-2′-deoxyuridine immunohistochemistry following UVD between the control group and the groups in which the candidate miRNA oligomers were administered. Administration of miR-218a-5p, 219a-5p, and 221-3p oligomers significantly affected vestibular compensation. Target pathway analysis of these miRNAs supported our results. Our findings suggest that the miRNAs 218a-5p, 219a-5p, and 221-3p regulate vestibular compensation.
GABA accretion reduces Lsi-1 and Lsi-2 gene expressions and modulates physiological responses in Oryza sativa to provide tolerance towards arsenic
Authors: Kumar Navin , Dubey Arvind Kumar , Upadhyay Atul Kumar , Gautam Ambedkar , Ranjan Ruma , Srikishna Saripella , Sahu Nayan , Behera Soumit Kumar , Mallick Shekhar
Published: August 2017

GABA counteracts wide range of stresses through regulation of GABA shunt pathway in plants. Although, GABA assisted tolerance against As toxicity in plants is still unexplored. We have examined GABA induced tolerance in rice seedlings with two exposure periods of GABA i.e., short term and long term. Results showed that accumulation of GABA reduced the expressions of Lsi-1 and Lsi-2 transporter genes, which ultimately decreased the accumulation of As in rice seedlings. The accumulation of GABA also modulated the gene expression of GABA shunt pathway and activity of antioxidant enzymes, which strongly induced the tolerance in plants. Antioxidant enzymes such as CAT, POD, GPX and SOD showed maximum alteration in activity with GABA accretion. In both exposure periods, long term accumulation of GABA was highly efficient to provide tolerance to plants against As(III), while higher level of GABA at short term was toxic. Tolerance responses of GABA towards As(III) was reflected by minimal changes in various physiological (WUE, A, gs, PhiPS2, qp, NPQ, ETR and Trmmol) and growth parameters with concomitant accumulation. Oxidative stress marker such as TBARS and H2O2 contents were reduced with GABA accumulation. These results suggested that GABA sturdily inhibits As accumulation and provides tolerance towards As(III).
Fifteen-year mortality trends in Poland analysed with the use of standard expected years of life lost, 2000–2014
Authors: Pikala Małgorzata , Maniecka-Bryła Irena
Published: August 2017

The aim of the study is an evaluation of years of life lost by inhabitants of Poland according to the most important causes of mortality and identification of trends in the period 2000–2014. The study material included a database which contained information gathered from 5,601,568 death certificates of inhabitants of Poland. In order to calculate years of life lost, the SEYLLp index (Standard Expected Years of Life Lost per living person) was applied. We also calculated AAPC (Average Annual Percentage Change). The SEYLLp index (per 10,000 population) in Poland decreased from 2503.4 in 2000 to 2193.2 in 2014 among males (AAPC = −0.8%, p < 0.05) and from 1430.2 in 2000 to 1269.4 in 2014 among females (AAPC = −0.6%, p < 0.05). In 2014, the top 5 causes of years of life lost were: cardiovascular diseases (721.4 per 10,000 males and 475.6 per 10,000 females), malignant tumours (575.5 and 418.3), unintentional injuries (202.2 and 46.8), intentional injuries (114.6 and 16.3) and digestive diseases (120.2 and 58.3). Due to negative trends, there is a need to implement preventative measures, aimed at reducing mortality caused by respiratory infections in both males and females, malignant tumours in females and diabetes mellitus and intentional injuries in males.
Broadband polarization conversion with anisotropic plasmonic metasurfaces
Authors: Cao Wei , Yang Xiaodong , Gao Jie
Published: August 2017

Metasurfaces offer exciting opportunities that enable precise control of light propagation, optical intensity, phase and polarization. Plasmonic metasurface based quarter-wave plates have been recently studied to realize the conversion between linear polarization and circular polarization. However, it is still quite challenging to directly measure the birefringent phase retardation introduced by metasurface wave plates with a reliable technique. Here, we report a high-performance broadband metasurface quarter-wave plate made of anisotropic T-shaped plasmonic antennas in near-infrared wavelength range, where the achromatic nearly 90° transmitted phase retardation through the metasurface is precisely characterized with an optical vortex based interferometric approach. Based on the measured transmission amplitude and phase of two orthogonal linear polarization components, nearly unit degree of linear polarization is extracted from the Stokes parameters, indicating excellent broadband polarization conversion between linearly and circularly polarized light through the metasurface. Our results will be an important step forward in the advancement of integrated metasurface devices for polarization conversion and beam manipulation, structured light control, as well as new spectroscopic and interferometric techniques for metasurface characterization.
Water-Soluble Epitaxial NaCl Thin Film for Fabrication of Flexible Devices
Authors: Lee Dong Kyu , Kim Sungjoo , Oh Sein , Choi Jae-Young , Lee Jong-Lam , Yu Hak Ki
Published: August 2017

We studied growth mechanisms of water-soluble NaCl thin films on single crystal substrates. Epitaxial growth of NaCl(100) on Si(100) and domain-matched growth of NaCl(111) on c-sapphire were obtained at thicknesses below 100 nm even at room temperature from low lattice mismatches in both cases. NaCl thin film, which demonstrates high solubility selectivity for water, was successfully applied as a water-soluble sacrificial layer for fabrication of several functional materials, such as WO3nano-helix and Sn doped In2O3nano-branches.
Preparation of pillar[5]arene-quinoline Langmuir–Blodgett thin films for detection of volatile organic compounds with host–guest principles
Authors: Kursunlu Ahmed Nuri , Acikbas Yaser , Ozmen Mustafa , Erdogan Matem , Capan Rifat
Published: August 2017

In this study, a novel pillar[5]arene-quinoline (P5-Q) as an organic material is used to fabricate Langmuir–Blodgett (LB) thin films and its organic vapor sensing properties have been investigated.
Probing biological redox chemistry with large amplitude Fourier transformed ac voltammetry
Authors: Adamson Hope , Bond Alan M. , Parkin Alison
Published: August 2017

A review of the insight into biological redox chemistry which has been enabled by the development of large amplitude Fourier transform ac voltammetry.
High-temperature growth of thick-shell CdSe/CdS core/shell nanoplatelets
Authors: Rossinelli Aurelio A. , Riedinger Andreas , Marqués-Gallego Patricia , Knüsel Philippe N. , Antolinez Felipe V. , Norris David J.
Published: August 2017

We present a simple high-temperature protocol to add uniform CdS shells to CdSe nanoplatelets, yielding improved fluorescence efficiency and stability.
In situ monitoring the viscosity change of an electrolyte in a Li–S battery
Authors: Ding Ning , Li Xiaodong , Chien Sheau Wei , Liu Zhaolin , Zong Yun
Published: August 2017

Li2S2is not a solid precipitate, but an electrolyte–soluble substance.
Neutral merocyanine dyes: for in vivo NIR fluorescence imaging of amyloid-β plaques
Authors: Yan Jin-wu , Zhu Jia-ying , Zhou Kai-xiang , Wang Jin-sheng , Tan Hui-ya , Xu Zhong-yong , Chen Shuo-bin , Lu Yu-ting , Cui Meng-chao , Zhang Lei
Published: August 2017

Two neutral merocyanine-based near-infrared fluorescent probes were for the first time developed through rational engineering of the classical cationic cyanine scaffold IR-780 for in vivo imaging of amyloid-β plaques.
Li@organic superhalogens: possible electrolytes in Li-ion batteries
Authors: Naaresh Reddy G. , Parida Rakesh , Giri Santanab
Published: August 2017

First principles calculations on Li salts of organic heterocyclic superhalogens confirm that they can be used as potential electrolytes in Li-ion batteries.
Enhanced cancer therapy by the marriage of metabolic alteration and mitochondrial-targeted photodynamic therapy using cyclometalated Ir(iii) complexes
Authors: Liu Jiangping , Jin Chengzhi , Yuan Bo , Chen Yu , Liu Xingguo , Ji Liangnian , Chao Hui
Published: August 2017

A series of DCA-Ir(iii) co-drug complexes were demonstrated to act in synergy by sensitizing cancer cell for PDT to achieve cancer-specifically enhanced two-photon PDT in the hypoxic muticellular tumor spheroids.
A highly stable polyoxometalate-based metal–organic framework with an ABW zeolite-like structure
Authors: Li Xiao-Xin , Shen Feng-Cui , Liu Jiang , Li Shun-Li , Dong Long-Zhang , Fu Qiang , Su Zhong-Min , Lan Ya-Qian
Published: August 2017

A novel polyoxometalate-based metal–organic framework (POMOF) with an ABW network, NENU-601, was synthesized in situ.
Correction: Synthesis and characterization of boron and nitrogen co-doped diamond crystals under high pressure and high temperature conditions
Authors: Hu Meihua , Bi Ning , Li Shangsheng , Su Taichao , Hu Qiang , Ma Hongan , Jia Xiaopeng
Published: August 2017

Correction for ‘Synthesis and characterization of boron and nitrogen co-doped diamond crystals under high pressure and high temperature conditions’ by Meihua Hu et al., CrystEngComm, 2017, 19, 4571–4575.
Dissociative adsorption dynamics of nitrogen on a Fe(111) surface
Authors: Nosir M. A. , Martin-Gondre L. , Bocan G. A. , Díez Muiño R.
Published: August 2017

The dissociative adsorption dynamics of N2 on clean Fe(111) surfaces is theoretically investigated by means of quasi-classical trajectory calculations based on a multidimensional potential energy surface built from density functional theory.
How the electron-deficient cavity of heterocalixarenes recognizes anions: insights from computation
Authors: Ortolan Alexandre O. , Caramori Giovanni F. , Matthias Bickelhaupt F. , Parreira Renato L. T. , Muñoz-Castro Alvaro , Kar Tapas
Published: August 2017

The nature of bridging heteroatoms in a heterocalixarene structure has a crucial role in anion recognition.
Langmuir–Blodgett films of perylene bisimide derivatives and fluorescent recognition of diamines
Authors: Shang Congdi , Wang Li , An Yanqin , Chen Ping , Chang Xingmao , Qi Yanyu , Kang Rui , Fang Yu
Published: August 2017

A fluorescent film was constructed with the well-known Langmuir–Blodgett technique, and it showed exceptional sensing performances for some diamine vapors.
Modeling the sensing characteristics of chemi-resistive thin film semi-conducting gas sensors
Authors: Ghosh Abhishek , Majumder S. B.
Published: August 2017

Modeling of sensor response with the operating temperature and thickness of the sensing film.
Electroluminescence of [Ru(bpy)3]2+ at gold and silver screen-printed electrodes followed by real-time spectroelectrochemistry
Authors: Martín-Yerga Daniel , Pérez-Junquera Alejandro , Hernández-Santos David , Fanjul-Bolado Pablo
Published: August 2017

Nothing like silver or gold. Electroluminescence behavior of [Ru(bpy)3]2+ is different in relation to processes occurring on silver and gold screen-printed electrodes.
Enhanced activity of desilicated Cu-SSZ-13 for the selective catalytic reduction of NOx and its comparison with steamed Cu-SSZ-13
Authors: Oord R. , ten Have I. C. , Arends J. M. , Hendriks F. C. , Schmidt J. , Lezcano-Gonzalez I. , Weckhuysen B. M.
Published: August 2017

Mesoporous Cu-SSZ-13 was created by first synthesizing zeolite H-SSZ-13 and subsequently desilicating the material by base leaching using NaOH in different concentrations.
Microwave-hydrothermal synthesis of a novel, recyclable and stable photocatalytic nanoreactor for recognition and degradation of tetracycline
Authors: Zhu Zhi , Yu Yang , Huang Hai , Yao Xin , Dong Hongjun , Liu Zhi , Yan Yongsheng , Li Chunxiang , Huo Pengwei
Published: August 2017

A unique Ppy@CdS/ZnFe2O4 nanoreactor is fabricated via the microwave-hydrothermal method and surface-imprinting technique, which effectively enhances the recyclability, stability, and selectivity for recognition and degradation of tetracycline under visible-light irradiation.
Perovskite alkali metal samarium borohydrides: crystal structures and thermal decomposition
Authors: Møller Kasper T. , Jørgensen Mathias , Fogh Alexander S. , Jensen Torben R.
Published: August 2017

Synthesis and characterisation of samarium containing perovskite-type bimetallic borohydrides for hydrogen storage.
Single and double-doping effects on the thermoelectric properties of two Zintl compounds: Eu11Bi8.07(2)Sn1.93and Eu10.74(2)K0.26Bi9.14(2)Sn0.86
Authors: Choi Woongjin , Lee Junsu , Lee Yunho , Ahn Kyunghan , You Tae-Soo
Published: August 2017

Eu10.74(2)K0.26Bi9.14(2)Sn0.86is the first example of having both cationic and anionic p-dopants in a single compound.
Quality components and antidepressant-like effects of GABA green tea
Authors: Teng Jie , Zhou Wen , Zeng Zhen , Zhao Wenfang , Huang Yahui , Zhang Xu
Published: August 2017

After vacuum anaerobic and aerobic treatment, the GABA content in green tea is significantly increased, reaching the standard of GABA tea. And daily oral GABA green tea extract can prevent depression or improve the depressive state of animals.
Recovery of rare earth elements with ionic liquids
Authors: Wang Kaiying , Adidharma Hertanto , Radosz Maciej , Wan Pingyu , Xu Xin , Russell Christopher K. , Tian Hanjing , Fan Maohong , Yu Jiang
Published: August 2017

This review focuses on the recovery of REEs from waste with ionic liquids (ILs) as dilutants and extractants to tackle the REE supply challenge.
Asymmetric motion of magnetically actuated artificial cilia
Authors: Hanasoge Srinivas , Ballard Matthew , Hesketh Peter J. , Alexeev Alexander
Published: August 2017

We demonstrate magnetically actuated synthetic cilia that exhibit biomimetic asymmetric beating.
Metallic nanoislands on graphene: a metamaterial for chemical, mechanical, optical, and biological applications
Authors: Marin Brandon C. , Ramírez Julian , Root Samuel E. , Aklile Eden , Lipomi Darren J.
Published: August 2017

Two current applications of metal nanoisland–graphene composites are shown.
Intercalated reduced graphene oxide and its content effect on the supercapacitance performance of the three dimensional flower-like β-Ni(OH)2 architecture
Authors: Parveen Nazish , Ansari Sajid Ali , Ansari S. G. , Fouad H. , Cho Moo Hwan
Published: August 2017

Anchoring of three dimensional (3D) metal oxides with a controlled morphology on a reduced graphene sheet (rGO) is a promising and challenging route towards the development of highly efficient electrode materials for supercapacitor applications.
Novel distyryl BODIPY–fullerene dyads: preparation, characterization and photosensitized singlet oxygen generation efficiency
Authors: Ünlü Hasan , Okutan Elif
Published: August 2017

Novel types of mono- and bis-distyryl-BODIPY–fullerene dyads, 6 and 7, were prepared by Bingel cyclopropanation.
Hybrid nanomaterials of WS2 or MoS2 nanosheets with liposomes: biointerfaces and multiplexed drug delivery
Authors: Liu Yibo , Liu Juewen
Published: August 2017

WS2 nanosheets adsorb intact DOPC liposomes via van der Waals force thereby allowing the co-delivery of multiple molecules into cancer cells.
Topology of polymer chains under nanoscale confinement
Authors: Satarifard Vahid , Heidari Maziar , Mashaghi Samaneh , Tans Sander J. , Ejtehadi Mohammad Reza , Mashaghi Alireza
Published: August 2017

Spatial confinement limits the conformational space accessible to biomolecules but the implications for bimolecular topology are not yet known.
Deep Fano resonance with strong polarization dependence in gold nanoplate–nanosphere heterodimers
Authors: Qin Feng , Lai Yunhe , Yang Jianhua , Cui Ximin , Ma Hongge , Wang Jianfang , Lin Hai-Qing
Published: August 2017

Gold nanoplate–nanosphere heterodimers support Fano resonance with strong polarization dependence and the Fano dip almost reaching the spectral background level.
Scalable synthesis of organic-soluble carbon quantum dots: superior optical properties in solvents, solids, and LEDs
Authors: Wu Minghong , Zhan Jing , Geng Bijiang , He Piaopiao , Wu Kuan , Wang Liang , Xu Gang , Li Zhen , Yin Luqiao , Pan Dengyu
Published: August 2017

Organic-soluble CQDs with long-wavelength fluorescent colors were produced, and have been investigated in nonpolar and polar solvents, films, and LED devices.
Palladium-catalyzed regioselective C–H bond arylations at the C3 position of ortho-substituted fluorobenzenes
Authors: Hfaiedh Anoir , Ben Ammar Hamed , Soulé Jean-François , Doucet Henri
Published: August 2017

We report herein the palladium-catalyzed C–H bond arylation of fluorobenzene derivatives at the ortho-position to the fluorine atom. Bromo, chloro or methoxy substituents at the fluorobenzenyl ortho-position can be used to increase the reactivity of the C–H bond at the C3 position.
Insight into the deprotonation at the half-equivalence point of (thio)amido-benzimidazoles in the presence of anions
Authors: Koeller S. , Lescure M.-H. , Davies C. , Desvergne J.-P. , Massip S. , Bibal B.
Published: August 2017

Three crystallographic structures highlight the acid–base half-equivalence point of hydrogen-bond donor (thio)amido-benzimidazoles induced by fluoride or benzoate salts with concomitant hydrogen-bonding and deprotonation as a merged synergic process.
Synthesis of clay-armored poly(vinylidene chloride-co-methyl acrylate) latexes by Pickering emulsion polymerization and their film-forming properties
Authors: Delafresnaye Laura , Dugas Pierre-Yves , Dufils Pierre-Emmanuel , Chaduc Isabelle , Vinas Jérôme , Lansalot Muriel , Bourgeat-Lami Elodie
Published: August 2017

Use of LAPONITE® clay platelets as Pickering stabilizers of vinylidene chloride-based latexes.
Versatile multicompartment nanoparticles constructed with two thermo-responsive, pH-responsive and hydrolytic diblock copolymers
Authors: Chen Shengli , Chang Xueying , Sun Pingchuan , Zhang Wangqing
Published: August 2017

Multicompartment block copolymer nanoparticles constructed with two smart diblock copolymers are prepared and their versatile morphology upon stimuli is demonstrated.
Recent advances in AIEgen-based luminescent metal–organic frameworks and covalent organic frameworks
Authors: Ma Li , Feng Xiao , Wang Shan , Wang Bo
Published: August 2017

This review gives a brief introduction to AIEgen-based MOFs and COFs and focuses on their photoluminescence properties and potential applications.
Ag nanoparticles supported on nickel foam: a flexible 3D electrode for methanol electrocatalytic oxidation
Authors: Yu Yanan , Cheng Yu , Guo Meisong , Li Chenzhong , Hu Jingbo
Published: August 2017

Ag nanoparticles were prepared on nickel foam electrode coated Nafion membranes for eletrocatalytic oxidation methanol.
Influence of ambient conditions on the evolution of wettability properties of an IR-, ns-laser textured aluminium alloy
Authors: Cardoso J. T. , Garcia-Girón A. , Romano J. M. , Huerta-Murillo D. , Jagdheesh R. , Walker M. , Dimov S. S. , Ocaña J. L.
Published: August 2017

The evolution over time of wettability properties of super hydrophobic Al2024 developed using an IR-, ns-laser was studied under different storage conditions.
Extraction kinetics of mixed rare earth elements with bifunctional ionic liquid using a constant interfacial area cell
Authors: Wang Yanliang , Wang Yabing , Zhou Haiyue , Li Fujian , Sun Xiaoqi
Published: August 2017

Extraction kinetics of mixed REEs including La–Lu plus Y except Pm using constant interfacial area cell as equipment and bifunctional ionic liquid as extractant were reported.
δ-MnO2nanofiber/single-walled carbon nanotube hybrid film for all-solid-state flexible supercapacitors with high performance
Authors: Wang Lu , Huang Miaomiao , Chen Shuangbao , Kang Liping , He Xuexia , Lei Zhibin , Shi Feng , Xu Hua , Liu Zong-Huai
Published: August 2017

A highly flexible symmetrical supercapacitor based on a δ-MnO2nanofiber/SWCNT hybrid film showed an energy density of 31.8 μW h cm−2at a power density of 0.815 mW cm−2.
Water-oxidation photoanodes using organic light-harvesting materials: a review
Authors: Kirner Joel T. , Finke Richard G.
Published: August 2017

A comprehensive review of the quickly growing body of research concerning the use of organic light-harvesting materials in water-oxidizing photoelectrochemical cells.
Polymerization and biosensor application of water soluble peptide-SNS type monomer conjugates
Authors: Soylemez Saniye , Yılmaz Tuğçe , Buber Ece , Udum Yasemin A. , Özçubukçu Salih , Toppare Levent
Published: August 2017

A simple and efficient approach for the preparation of a biosensing platform was developed based on newly designed peptide-SNS type monomer conjugates.
Polarized emission effect realized in CH3NH3PbI3 perovskite nanocrystals
Authors: Shi Zhi-Feng , Li Ying , Li Sen , Ji Hui-Fang , Lei Ling-Zhi , Wu Di , Xu Ting-Ting , Xu Jun-Min , Tian Yong-Tao , Li Xin-Jian
Published: August 2017

A polarized emission effect has been realized in CH3NH3PbI3 perovskite nanocrystals with a linear polarization degree of 0.28.
Desymmetrization of Hepta-1,6-dien-4-ol by a Highly Stereo­selective Tandem Prins–Ritter Cyclization: Access to New THP
Acetamides
Authors: Glachet Thomas , Fache Fabienne , Pelotier Béatrice , Piva Olivier
Published: August 2017

Prins–Ritter cyclization performed from hepta-1,6-dien-4-ol and various aldehydes, promoted by bismuth(II) triflate, afforded N-(tetrahydropyranyl)acetamides in moderate to high yields. Subsequent Wacker-type oxidation using Dess–Martin periodinane (DMP) delivered the corresponding ketones.
An Approach to 1,1-Disubstituted Pyrazolylcyclopropane Building Blocks
Authors: Nosik Pavel , Artamonov Oleksiy , Ryabukhin Sergey , Grygorenko Oleksandr
Published: August 2017

An approach to isomeric 1,1-disubstituted pyrazolylcyclopropanes that relies on lithium diisopropylamide (LDA) mediated bis-alkylation­ of the corresponding pyrazolylacetonitriles is developed. The building blocks obtained can be considered as lead-like bioisosteres of arylpyrazole and pyrazolecarboxamide moieties and are thus useful for early drug discovery projects.
Effect of Monopolar Cutting Mode against Bipolar Diathermy on Surgical Dissection of Microvessels
Authors: Suh Hyunsuk , Park Eun , Hong Joon
Published: August 2017

Background An ideal vessel dissection will be to maximize bleeding control through coagulation while minimizing vessel damage. Among the diathermy methods, there has been no report comparing the effect on vessels. This study aims to verify the effect of bipolar diathermy against monopolar diathermy cutting mode for vessel dissection.

Methods A total of 18 Sprague–Dawley rats were divided into three groups according to the method of pedicle dissection for 6 × 6 cm sized abdominal flap; (group 0) surgical scissors, (group 1) monopolar diathermy cutting mode and (group 2) bipolar diathermy. They were evaluated for the temperature of device tip and the radiating heat to the surrounding tissue, change in vessel diameter, flow velocity, and perfusion to the skin flap during dissection. Final flap survival rate and pathology of the vessels were also evaluated.

Results Significantly higher radiating heat was observed using bipolar diathermy (average: 37.5°C) compared with group using monopolar diathermy (average: 34.4°C) (p value 0.045). However, there were no differences in vessel diameter, skin flap perfusion, flow velocity, and flap survival rate among the groups.

Conclusions Both monopolar diathermy cutting mode and bipolar diathermy are safe to use to dissect the pedicle vessels when used adequately. Although it has no significant difference in relations to flap survival, vessel spasm, and perfusion/velocity to the flap, the extent of histologic damage may be less in monopolar diathermy cutting mode. Using monopolar diathermy cutting mode may provide efficiency to achieve ligation in small vessels during pedicle dissection but requires finesse technique and a learning curve.
Surgical Treatment of Ebstein's Anomaly
Authors: Lange Rüdiger , Burri Melchior
Published: August 2017

Surgical repair of the tricuspid valve is a milestone in the medical history of patients with Ebstein's anomaly. The timely alleviation of the insufficiency has an important impact on the prognosis. In this review, we describe features of the disease relevant to surgical correction and the evolution of surgical techniques over six decades. We compare the results of different repair and replacement techniques. Additionally, we discuss concomitant antiarrhythmic surgery and bailout strategies for postoperative right ventricular failure. Finally, we review the surgical options in symptomatic neonates with Ebstein's disease.
The Oxytocin Product Correlates with Total Oxytocin Received during Labor: A Research Methods Study
Authors: Lewis Lauren , Manuck Tracy , Allen Terrence , James Andra , Seco Aurelien , Deneux-Tharaux Catherine , Grotegut Chad
Published: August 2017

Objective Total dose of oxytocin received during labor is an important variable in studies of human labor but is difficult to calculate. We sought to identify a surrogate measure for total dose of oxytocin received.

Study Design For each subject receiving oxytocin during labor, the oxytocin total dose received in labor was calculated as the area under the curve. Maximal oxytocin infusion rate, total duration of oxytocin infusion, and the product of both, defined as the oxytocin product, were then each correlated with the total dose of oxytocin received using the Pearson's correlation coefficient.

Results Oxytocin dosing data were available from 402 women at Duke and 6,907 women from Pithagore6. The two variables alone, or combined as the oxytocin product, demonstrated a high correlation with the oxytocin total dose (r > 0.7), with the oxytocin product demonstrating the highest (r > 0.9). This was true whether labor was induced or augmented and whether delivery was vaginal or cesarean.

Conclusion The oxytocin product, composed of two easily obtained variables, demonstrated a very high correlation with total oxytocin dose received in labor and represents a simple and accurate surrogate for total dose of oxytocin received during labor. The oxytocin product can be used in clinical studies in which oxytocin dose is an important variable.
Dynamische Stabilisierung des Skaphoids mit Extensor carpi radialis longus-Sehnenstreifen und freiem Palmaris
longus-Sehneninterponat bei skapholunärer Instabilität
Authors: Soleman Evelin , Fatzer Lukas , Sanchez Tomas
Published: August 2017

Der vorliegende Artikel beschreibt unsere Technik der dynamischen Skaphoidstabilisierung zur Behandlung einer statischen, reponiblen
skapholunären Dissoziation.
Die dorsale Bandplastik bei posttraumatischer skapholunärer Dissoziation
Authors: Bajinski Ralf , Gülke Joachim , Mentzel Martin , Sigloch Florian , Dustmann Moritz , Wachter Nikolaus Johannes
Published: August 2017

Die veraltete skapholunäre Dissoziation (SLD) Stadium 2 und 3 kann bei fehlender Therapie zu posttraumatischen Folgeschäden führen.
Verschiedene Therapieansätze wie Kapsulodesen, Tenodesen oder andere Verfahren wurden beschrieben. Ziel aller Verfahren ist die
Palmarkippung des Kahnbeines mit nachfolgender Arthrose (SLAC-wrist) zu vermeiden. Ziel dieser Studie war die Evaluation der Ergebnisse
einer in unserem Haus durchgeführten modifizierten dorsalen Bandplastik bei Patienten mit SLD 2° und 3° im Rahmen eines prospektiven
Studiendesigns. Weiterhin sollte ermittelt werden, ob eine Korrelation zwischen klinischen und radiologischen Parametern besteht und ob
durch die Operation die Entstehung eines SLAC-wrist verhindert werden kann. In unserer Klinik wurden zwischen 2007 und 2011 29 Patienten mit
einer modifizierten dorsalen Bandplastik bei veralteter SLD 2° und 3° operativ versorgt. Im Rahmen der prospektiven Studie konnten 25
Patienten nach durchschnittlich 18 Monaten nachuntersucht werden. Präoperativ wurden die klinischen Parameter ROM, DASH und VAS-Schmerzskala
sowie die radiologischen Parameter SL-Distanz in Ruhe und Kraftgriff sowie SL-Winkel erhoben; postoperativ zusätzlich die Greifkraft der
operierten und der gesunden Gegenseite, der Mayo Wrist Score (MWS) und die subjektive Gesamtbeurteilung. Die subjektive Gesamtbeurteilung
postoperativ lag bei durchschnittlich gut. Die postoperative Beweglichkeit ROM lag bei 83,8 % der ROM der gesunden Gegenseite und
verminderte sich im Vergleich zu präoperativ um 11 % (nicht signifikant). Die postoperative Kraft lag bei 85,7 % der Kraft der gesunden
Gegenseite. Die VAS-Schmerz-Skala lag postoperativ bei durchschnittlich 2,7, präoperativ bei durchschnittlich 6,7, die Schmerzabnahme war
signifikant. Der postoperative DASH-Score lag präoperativ bei 60 und verbesserte sich postoperativ signifikant auf 22,5. Der postoperative
MWS lag bei 73. Alle postoperativen radiologischen Parameter waren signifikant verbessert (p < 0,001), lagen aber durchschnittlich noch
im pathologischen Bereich. In der Pearson Korrelationsanalyse zeigte sich keine relevanten Korrelationen zwischen den radiologischen
Parametern und den klinischen Scores. In 3 Fällen (12 %) waren Folgeoperationen nötig. Die beschriebene modifizierte dorsale Bandplastik
bietet eine Therapieoption bei veralteter SLD Grad 2 und 3. Sie lieferte gute klinische Ergebnisse bei geringer Komplikationsrate und
kleiner Zugangsmorbidität. Kritisch zu sehen ist die geringe Nachuntersuchungszeit von durchschnittlich 18 Monaten, eine erhöhte SLAC-Rate
bei längerer Nachuntersuchungszeit kann nicht ausgeschlossen werden.
Therapie des Morbus Dupuytren mit Injektion von Kollagenase in Deutschland – Ergebnisse und Komplikationen an 110
Gelenken
Authors: Pototschnig Adrian , Volkmer Elias , Giunta Riccardo E.
Published: August 2017

Hintergrund Seit 2011 steht in Deutschland mit der Injektion von mikrobieller Kollagenase (Xiapex®, Fa. Pfizer) ein neues
minimalinvasives Verfahren zur Therapie des Morbus Dupuytren zur Verfügung.

Ziel Wir berichten über die aktuelle Situation, Ergebnisse und Komplikationen nach Injektion von mikrobieller Kollagenase zur Therapie
des Morbus Dupuytren in Deutschland.

Patienten und Methoden In unserer Studie wurde 78 Patienten (61 Männer, 17 Frauen) mit 87 Injektionen an 87 Strahlen (Kleinfinger n =
40, Ringfinger n = 37, Mittelfinger n = 8 und Zeigefinger n = 2) behandelt, und wir konnten davon 39 Patienten (32 Männer, 7 Frauen) über
einen Zeitraum von 6 Monaten prospektiv beobachtet. Wir dokumentierten Kontrakturgrade prätherapeutisch, nach 6 Wochen und nach 6
Monaten.

Ergebnisse Am MCP-Gelenk (n = 26) erfolgte eine Korrektur von durchschnittlich 51° auf 0° (p < 0,05). Nach 6 Monaten konnte die
Kontraktur am MCP-Gelenk (n = 16) von durchschnittlich 52° auf 0° reduziert werden (p < 0,05). Die initiale Korrektur am PIP-Gelenk (n =
28) belief sich von durchschnittlich 63° auf 15° (p < 0,05). Nach 6 Monaten zeigte sich am PIP-Gelenk (n = 12) eine durchschnittliche
Reduktion von 70° auf 40° (p < 0,05). Bei kombinierten Kontrakturen von MCP- und PIP-Gelenk (n = 33) ergab sich eine Korrektur von 96°
auf 13° (p < 0,05). Nach 6 Monaten zeigte sich bei den kombinierten Kontrakturen (n = 16) eine Korrektur von 91° auf 61° (p < 0,05).
Als häufige Nebenwirkungen registrierten wir lokale Schwelllungen (n = 36), gefolgt von Hämatomen (n = 25), temporären lividen Verfärbungen
(n = 17) und Hautrissen (n = 16). Es kam zu keinen schweren Komplikationen wie Beugesehnen-, Gefäß- oder Nervenverletzungen. Die schwersten
Komplikationen waren 4 kleine Hautdefekte, die jedoch im Verlauf mit konservativer Wundbehandlung abheilten.

Schlussfolgerung Verglichen mit internationalen Studien präsentieren wir vergleichbare Resultate. Hervorzuheben sind die guten
Ergebnisse mit nur einer Injektion bei hohen prätherapeutischen Kontrakturgraden am MCP-Gelenk und respektable Erfolge bei kombinierten
Kontrakturen an beiden Gelenken mit nur einer Injektion. Es traten keine schwerwiegenden Komplikationen auf. Die Nebenwirkungen entsprechen
dem Spektrum vergleichbarer Studien. Wir sind der Meinung, dass die Injektion von mikrobieller Kollagenase eine komplikationsarme und
erfolgversprechende Therapieoption zur Behandlung des M. Dupuytren darstellt. Endgültige Aussagen zur Effektivität im Vergleich zur
perkutanen Nadelfasziotomie (PNF) und partiellen Aponeurektomie müssen weitere Langzeitstudien untersuchen.