bluuebunny/crossref_metadata_2025 huggingface dataset:
Task-Based Model Observer Assessment of A Partial Model-Based Iterative Reconstruction Algorithm in Thoracic Oncologic Multidetector CT
Authors: Rotzinger David C. , Racine Damien , Beigelman-Aubry Catherine , Alfudhili Khalid M. , Keller Nathalie , Monnin Pascal , Verdun Francis R. , Becce Fabio
Published: December 2018

To investigate the impact of a partial model-based iterative reconstruction (ASiR-V) on image quality in thoracic oncologic multidetector computed tomography (MDCT), using human and mathematical model observers. Twenty cancer patients examined with regular-dose thoracic-abdominal-pelvic MDCT were retrospectively included. Thoracic images reconstructed using a sharp kernel and filtered back-projection (reference) or ASiR-V (0–100%, 20% increments; follow-up) were analysed by three thoracic radiologists. Advanced quantitative physical metrics, including detectability indexes of simulated 4-mm-diameter solid non-calcified nodules and ground-glass opacities, were computed at regular and reduced doses using a custom-designed phantom. All three radiologists preferred higher ASiR-V levels (best = 80%). Increasing ASiR-V substantially decreased noise magnitude, with slight changes in noise texture. For high-contrast objects, changing the ASiR-V level had no major effect on spatial resolution; whereas for lower-contrast objects, increasing ASiR-V substantially decreased spatial resolution, more markedly at reduced dose. For both high- and lower-contrast pulmonary lesions, detectability remained excellent, regardless of ASiR-V and dose levels, and increased significantly with increasing ASiR-V levels (all p < 0.001). While high ASiR-V levels (80%) are recommended to detect solid non-calcified nodules and ground-glass opacities in regular-dose thoracic oncologic MDCT, care must be taken because, for lower-contrast pulmonary lesions, high ASiR-V levels slightly change noise texture and substantially decrease spatial resolution, more markedly at reduced dose.
Insight into Elongation Stages of Peptidoglycan Processing in Bacterial Cytoplasmic Membranes
Authors: Kim Seonghoon , Pires Marcos M. , Im Wonpil
Published: December 2018

Peptidoglycan (PG) biosynthesis and assembly are needed for bacterial cell wall formation. Lipid II is the precursor in the PG biosynthetic pathway and carries a nascent PG unit that is processed by glycosyltransferases. Despite its immense therapeutic value as a target of several classes of antibiotics, the conformational ensemble of lipid II in bacterial membranes and its interactions with membrane-anchored enzymes remain elusive. In this work, lipid II and its elongated forms (lipid VI and lipid XII) were modeled and simulated in bilayers of POPE (palmitoyl-oleoyl-phosphatidyl-ethanolamine) and POPG (palmitoyl-oleoyl-phosphatidyl-glycerol) that mimic the prototypical composition of Gram-negative cytoplasmic membranes. In addition, penicillin-binding protein 1b (PBP1b) from Escherichia coli was modeled and simulated in the presence of a nascent PG to investigate their interactions. Trajectory analysis reveals that as the glycan chain grows, the non-reducing end of the nascent PG displays much greater fluctuation along the membrane normal and minimally interacts with the membrane surface. In addition, dihedral angles within the pyrophosphate moiety are determined by the length of the PG moiety and its surrounding environment. When a nascent PG is bound to PBP1b, the stem peptide remains in close contact with PBP1b by structural rearrangement of the glycan chain. Most importantly, the number of nascent PG units required to reach the transpeptidase domain are determined to be 7 or 8. Our findings complement experimental results to further understand how the structure of nascent PG can dictate the assembly of the PG scaffold.
DPTIP, a newly identified potent brain penetrant neutral sphingomyelinase 2 inhibitor, regulates astrocyte-peripheral immune communication following brain inflammation
Authors: Rojas Camilo , Barnaeva Elena , Thomas Ajit G. , Hu Xin , Southall Noel , Marugan Juan , Chaudhuri Amrita Datta , Yoo Seung-Wan , Hin Niyada , Stepanek Ondrej , Wu Ying , Zimmermann Sarah C. , Gadiano Alexandra G. , Tsukamoto Takashi , Rais Rana , Haughey Norman , Ferrer Marc , Slusher Barbara S.
Published: December 2018

Brain injury and inflammation induces a local release of extracellular vesicles (EVs) from astrocytes carrying proteins, RNAs, and microRNAs into the circulation. When these vesicles reach the liver, they stimulate the secretion of cytokines that mobilize peripheral immune cell infiltration into the brain, which can cause secondary tissue damage and impair recovery. Recent studies suggest that suppression of EV biosynthesis through neutral sphingomyelinase 2 (nSMase2) inhibition may represent a new therapeutic strategy. Unfortunately, currently available nSMase2 inhibitors exhibit low potency (IC50 ≥ 1 μM), poor solubility and/or limited brain penetration. Through a high throughput screening campaign of >365,000 compounds against human nSMase2 we identified 2,6-Dimethoxy-4-(5-Phenyl-4-Thiophen-2-yl-1H-Imidazol-2-yl)-Phenol (DPTIP), a potent (IC50 30 nM), selective, metabolically stable, and brain penetrable (AUCbrain/AUCplasma = 0.26) nSMase2 inhibitor. DPTIP dose-dependently inhibited EV release in primary astrocyte cultures. In a mouse model of brain injury conducted in GFAP-GFP mice, DPTIP potently (10 mg/kg IP) inhibited IL-1β-induced astrocyte-derived EV release (51 ± 13%; p < 0.001). This inhibition led to a reduction of cytokine upregulation in liver and attenuation of the infiltration of immune cells into the brain (80 ± 23%; p < 0.01). A structurally similar but inactive analog had no effect in vitro or in vivo.
The expression of ecdysteroid UDP-glucosyltransferase enhances cocoon shell ratio by reducing ecdysteroid titre in last-instar larvae of silkworm, Bombyx mori
Authors: Shen Guanwang , Wu Jinxin , Wang Yong , Liu Hongling , Zhang Haiyan , Ma Sanyuan , Peng Chuyue , Lin Ying , Xia Qingyou
Published: December 2018

Ecdysteroid UDP glucosyltransferase (EGT) is a baculovirus-encoded protein which can hinder the normal molting of insects by inactivating 20-hydroxyecdysone (20E). Here we expressed EGT in the last-instar silkworm larvae using the GAL4/ UAS system. Compared with the control, for the EGT overexpressed silkworm, the hemolymph 20E content was significantly decreased, the feeding and spinning periods of the last-instar silkworm larvae were extended, the cocoon shell ratio was significantly increased, and the transformation from silkworm larvae to pupa was blocked. Increasing EGT expression resulted in the decrease of 20E content in the hemolymph of silkworm larvae, treating the EGT overexpressed male silkworm with 20E decreased the larval weight and cocoon shell ratio, confirming that the increase in the availability of nutrients to the cocoon and an increase in the cocoon shell weight in the hybrid transgenic silkworms is because of the EGT-induced reduction in active 20E content. Furthermore, though the sericin and flavonoid contents were increased in the cocoon of the EGT overexpressing silkworm, the production of silk fibroin didn’t change.
New mass spectrometry technologies contributing towards comprehensive and high throughput omics analyses of single cells
Authors: Couvillion Sneha P. , Zhu Ying , Nagy Gabe , Adkins Joshua N. , Ansong Charles , Renslow Ryan S. , Piehowski Paul D. , Ibrahim Yehia M. , Kelly Ryan T. , Metz Thomas O.
Published: December 2018

We provide a vision for integrating pioneering mass spectrometry technologies for future applications in single cell analysis.
Direct sampling mass spectrometry for clinical analysis
Authors: Pu Fan , Chiang Spencer , Zhang Wenpeng , Ouyang Zheng
Published: December 2018

Direct sampling mass spectrometry enables high-performance clinical analysis, such as imaging, drug monitoring and point-of-care testing.
Deposition of CdTe quantum dots on microfluidic paper chips for rapid fluorescence detection of pesticide 2,4-D
Authors: Zhang Zhong , Ma Xin , Jia Mengfan , Li Bowei , Rong Jianhui , Yang Xingbin
Published: December 2018

Novel fluorescent microfluidic paper chips were developed by the combination of molecularly imprinted polymers and microfluidic paper chips with CdTe quantum dots for the specific recognition and sensitive detection of the pesticide 2,4-D.
Accurate flow in augmented networks (AFAN): an approach to generating three-dimensional biomimetic microfluidic networks with controlled flow
Authors: Guo Jiaming , Keller Keely A. , Govyadinov Pavel , Ruchhoeft Paul , Slater John H. , Mayerich David
Published: December 2018

A network augmentation approach that adds synthetic connections to microvascular networks to induce biomimetic microfluidic flow.
Retraction: The next generation cell-penetrating peptide and carbon dot conjugated nano-liposome for transdermal delivery of curcumin
Authors: Hammond Neil
Published: December 2018

Retraction of ‘The next generation cell-penetrating peptide and carbon dot conjugated nano-liposome for transdermal delivery of curcumin’ by Santanu Patra et al., Biomater. Sci., 2016, 4, 418–429.
β-Glucan as an immune activator and a carrier in the construction of a synthetic MUC1 vaccine
Authors: Wang Hanxuan , Yang Bing , Wang Yinglu , Liu Fen , Fernández-Tejada Alberto , Dong Suwei
Published: December 2018

We describe the preparation of a cancer vaccine candidate by conjugating a MUC1 peptide antigen to the β-glucan polysaccharide, which serves both as a carrier and an immune activator.
Robust multivariate metal–porphyrin frameworks for efficient ambient fixation of CO2 to cyclic carbonates
Authors: He Liang , Nath Jayanta Kumar , Lin Qipu
Published: December 2018

A series of robust polyfluorometalate-metalloporphyrin nets have three-types of orderly distributed metals, high CO2-trapping capacity and good catalytic properties for coupling CO2 with epoxides.
Solar-driven CO2 to CO reduction utilizing H2O as an electron donor by earth-abundant Mn–bipyridine complex and Ni-modified Fe-oxyhydroxide catalysts activated in a single-compartment reactor
Authors: Arai Takeo , Sato Shunsuke , Sekizawa Keita , Suzuki Tomiko M. , Morikawa Takeshi
Published: December 2018

Solar-driven CO2 reduction utilizing earth-abundant catalysts of a Mn-complex and Ni-modified β-FeOOH was demonstrated in a single-compartment reactor.
Versatile approach to activation of alkoxyamine homolysis by 1,3-dipolar cycloaddition for efficient and safe nitroxide mediated polymerization
Authors: Edeleva Mariya , Morozov Denis , Parkhomenko Dmitriy , Polienko Yulia , Iurchenkova Anna , Kirilyuk Igor , Bagryanskaya Elena
Published: December 2018

In situ activation of alkoxyamine towards C–ON bond homolysis by 1,3-dipolar cycloaddition with monomers is reported.
On the structural stability of crystalline ceria phases in undoped and acceptor-doped ceria materials under in situ reduction conditions
Authors: Bekheet Maged F. , Grünbacher Matthias , Schlicker Lukas , Gili Albert , Doran Andrew , Epping Jan Dirk , Gurlo Aleksander , Klötzer Bernhard , Penner Simon
Published: December 2018

Pure and acceptor-doped CeO2 materials undergo different sequences of structural transformations during hydrogen treatment without crystalline hydride formation.
Dynamic characteristics of defect dipoles in Mn-doped 0.24Pb(In1/2Nb1/2)O3–0.47Pb(Mg1/3Nb2/3)O3–0.29PbTiO3 single crystal
Authors: Qi Xudong , Sun Enwei , Lü Weiming , Li Shiyang , Yang Bin , Zhang Rui , Cao Wenwu
Published: December 2018

The dynamic ferroelectric hysteresis loops with internal bias field were investigated in poled and aged Mn-doped 0.24Pb(In1/2Nb1/2)O3–0.47Pb(Mg1/3Nb2/3)O3–0.29PbTiO3 single crystal.
Anisotropic magnetic nanoparticles for biomedicine: bridging frequency separated AC-field controlled domains of actuation
Authors: Serantes David , Chantrell Roy , Gavilán Helena , Morales María del Puerto , Chubykalo-Fesenko Oksana , Baldomir Daniel , Satoh Akira
Published: December 2018

Hexagonal-shape magnetic nanoparticles for efficient alternation between magneto-mechanical actuation and heating.
Electronic transport in a graphene single layer: application in amino acid sensing
Authors: Rodríguez Sindy J. , Albanesi Eduardo A.
Published: December 2018

We modeled a type of field-effect transistor device based on graphene for the recognition of amino acids with a potential application in the building of a protein sequencer.
Using a monomer potential energy surface to perform approximate path integral molecular dynamics simulation of ab initio water at near-zero added cost
Authors: Elton Daniel C. , Fritz Michelle , Fernández-Serra Marivi
Published: December 2018

We present a new approximate method for doing path integral molecular dynamics simulation with density functional theory and show the utility of the method for liquid water.
Multi-electron reduction of Wells–Dawson polyoxometalate films onto metallic, semiconducting and dielectric substrates
Authors: Douvas Antonios M. , Tsikritzis Dimitris , Tselios Charalampos , Haider Ali , Mougharbel Ali S. , Kortz Ulrich , Hiskia Anastasia , Coutsolelos Athanassios G. , Palilis Leonidas C. , Vasilopoulou Maria , Kennou Stella , Argitis Panagiotis
Published: December 2018

The thermally-induced multi-electron reduction of [P2Mo18O62]6−anions onto dielectric substrate (SiO2) under ambient conditions is attributed to the oxidation of ammonium counterions.
Ni-Doped CuS as an efficient electrocatalyst for the oxygen evolution reaction
Authors: Kundu Joyjit , Khilari Santimoy , Bhunia Kousik , Pradhan Debabrata
Published: December 2018

Ni-Doped CuS synthesized by a facile solvothermal method is demonstrated as an efficient oxygen evolution catalyst in alkaline medium.
Polynuclear Cu(i) and Ag(i) phosphine complexes containing multi-dentate polytopic ligands: syntheses, crystal structures and photoluminescence properties
Authors: Xiang Jing , Cheng Shun-Cheung , Jin Xin-Xin , Su Qian-Qian , Zhou Xin , Chu Wing-Kin , Leung Chi-Fai , Ko Chi-Chiu
Published: December 2018

A series of polynuclear Cu(i)/Ag(i) complexes have been obtained on the basis of three polytopic ligands. Their structures and photophysical properties have been investigated in detail.
Concluding remarks
Authors: van der Avoird Ad
Published: December 2018

The Faraday Discussion on quantum effects in small molecular systems was held on 10th – 12th September 2018 in Edinburgh, UK. It reflected a wide variety of new theoretical and experimental developments, which provide insights and methods applicable to larger systems as well.
Catalytic transfer hydrogenation of oleic acid to octadecanol over magnetic recoverable cobalt catalysts
Authors: Wang Juncheng , Nie Renfeng , Xu Ling , Lyu Xilei , Lu Xiuyang
Published: December 2018

Earth-abundant magnetic cobalt is highly efficient for CTH of oleic acid with isopropanol as a hydrogen donor, affording 100% conversion as well as 91.9% octadecanol yield at 200 °C, which can be ascribed to the synergistic effect between Coδ+ and Co0.
Personalised organs-on-chips: functional testing for precision medicine
Authors: van den Berg Albert , Mummery Christine L. , Passier Robert , van der Meer Andries D.
Published: December 2018

Organs-on-chips can be ‘personalised’ so they can be used as functional tests to inform clinical decision-making for specific patients.
Contrasting interactions of DNA-intercalating dye acridine orange with hydroxypropyl derivatives of β-cyclodextrin and γ-cyclodextrin hosts
Authors: Sayed Mhejabeen , Gubbala Ganesh K. , Pal Haridas
Published: December 2018

The present study demonstrates contrasting binding interactions of acridine orange dye with HPβCD and HPγCD hosts, always illustrating fluoresence “turn on” in the case of HPβCD and showing an interesting fluorescence “off/on switching” in the case of the HPγCD host.
Coumarin–graphene turn-on fluorescent probe for femtomolar level detection of copper(ii)
Authors: Akhila A. K. , Renuka N. K.
Published: December 2018

A novel coumarin–graphene moiety was suggested as an excellent optical sensor for Cu2+ions.
One-step fabrication of a boric acid-functionalized lanthanide metal–organic framework as a ratiometric fluorescence sensor for the selective recognition of dopamine
Authors: Du Qiuzheng , Wu Pu , Dramou Pierre , Chen Rong , He Hua
Published: December 2018

A boric acid-functionalized Eu-MOF ratiometric fluorescence sensor was prepared for the selective recognition of dopamine.
Competitive self-assembly driven as a route to control the morphology of poly(tannic acid) assemblies
Authors: Liu Zhiqing , Fan Haiyan , Li Wei , Bai Guoqiang , Li Xie , Zhao Ning , Xu Jian , Zhou Feng , Guo Xuhong , Dai Bin , Benassi Enrico , Jia Xin
Published: December 2018

A promising route to obtain two distinct poly(tannic acid) (PTA) assemblies patterns through solvent-induced supramolecular self-assembly is described.
Bimodal atomic force microscopy for the characterization of thiolated self-assembled monolayers
Authors: Athanasopoulou Evangelia-Nefeli , Nianias Nikolaos , Ong Quy Khac , Stellacci Francesco
Published: December 2018

In-depth analysis of self-assembled monolayers by bimodal atomic force microscopy.
Rational design of ordered Pd–Pb nanocubes as highly active, selective and durable catalysts for solvent-free benzyl alcohol oxidation
Authors: Tang Chongyang , Zhang Nan , Shao Qi , Huang Xiaoqing , Xiao Xiangheng
Published: December 2018

Ordered Pd–Pb nanocubes (NCs) were adopted as efficient heterocatalysts for the selective benzyl alcohol oxidation. Due to the ordered phase and well-defined surface, the Pd–Pb NCs can achieve superior activity and selectivity, better than those of other catalysts as we prepared.
Textile-based high-performance hydrogen evolution of low-temperature atomic layer deposition of cobalt sulfide
Authors: Kim Donghyun , Song Jeong-Gyu , Yang Hyungmo , Lee Hoonkyung , Park Jusang , Kim Hyungjun
Published: December 2018

Hydrogen is an appealing green energy resource to meet increasing energy demands.
Retraction: Amino acid derived highly luminescent, heteroatom-doped carbon dots for label-free detection of Cd2+/Fe3+, cell imaging and enhanced antibacterial activity
Authors: Shore Andrew
Published: December 2018

Retraction of ‘Amino acid derived highly luminescent, heteroatom-doped carbon dots for label-free detection of Cd2+/Fe3+, cell imaging and enhanced antibacterial activity’ by Paramita Karfa et al., RSC Adv., 2015, 5, 58141–58153.
Retraction: Creation of ultrasound and temperature-triggered bubble liposomes from economical precursors to enhance the therapeutic efficacy of curcumin in cancer cells
Authors: Shore Andrew
Published: December 2018

Retraction of ‘Creation of ultrasound and temperature-triggered bubble liposomes from economical precursors to enhance the therapeutic efficacy of curcumin in cancer cells’ by Santanu Patra et al., RSC Adv., 2016, 6, 85473–85485.
Lytic reactions of drugs with lipid membranes
Authors: Britt Hannah M. , García-Herrero Clara A. , Denny Paul W. , Mosely Jackie A. , Sanderson John M.
Published: December 2018

The involvement of drugs in direct chemical reactions with lipids may be linked to toxic effects in liver cell lines.
Nonlinear bending deformation of soft electrets and prospects for engineering flexoelectricity and transverse (d31) piezoelectricity
Authors: Rahmati Amir Hossein , Yang Shengyou , Bauer Siegfried , Sharma Pradeep
Published: December 2018

In this work, we analyze nonlinear bending deformation of a soft electret structure and examine the precise conditions that may lead to a strong emergent piezoelectric or flexoelectric response under bending.
Disparity in anomalous diffusion of proteins searching for their target DNA sites in a crowded medium is controlled by the size, shape and mobility of macromolecular crowders
Authors: Dey Pinki , Bhattacherjee Arnab
Published: December 2018

Using extensive computer simulations, we analyzed the role of physical properties of molecular crowding agents such as size, shape and mobility in the target search dynamics of DNA binding proteins.
Temperature dependence of the pitch in chiral lyotropic chromonic liquid crystals
Authors: Ogolla Timothy , Paley Robert S. , Collings Peter J.
Published: December 2018

Polarized optical microscopy image of a fingerprint texture for a lyotropic chromonic liquid crystal entering the chiral nematic–isotropic coexistence region. The helical axis is in the plane of the image and the perpendicular distance between the stripes is around 50 μm, half the chiral nematic pitch.
Pharmacogenetic association between NAT2 gene polymorphisms and isoniazid induced hepatotoxicity: trial sequence meta-analysis as evidence
Authors: Khan Saif , Mandal Raju K. , Elasbali Abdulbaset Mohamed , Dar Sajad A. , Jawed Arshad , Wahid Mohd , Mahto Harishankar , Lohani Mohtashim , Mishra Bhartendu Nath , Akhter Naseem , Rabaan Ali A. , Haque Shafiul
Published: December 2018

Hepatotoxicity is a severe problem generally faced by tuberculosis (TB) patients. It is a well-known adverse reaction due to anti-TB drugs in TB patients undergoing long-term treatment. The studies published previously have explored the connection of N-acetyltransferase 2 (NAT2) gene polymorphisms with isoniazid-induced hepatotoxicity, but the results obtained were inconsistent and inconclusive. A comprehensive trial sequence meta-analysis was conducted employing 12 studies comprising 3613 controls and 933 confirmed TB cases using the databases namely, EMBASE, PubMed (Medline) and Google Scholar till December 2017. A significant association was observed with individuals carrying variant allele at position 481C>T (T vs. C: P = 0.001; OR = 1.278, 95% CI = 1.1100–1.484), at position 590G>A (A vs. G: P = 0.002; OR = 1.421, 95% CI = 1.137–1.776) and at position 857G>A (A vs. G: P = 0.0022; OR = 1.411, 95% CI = 1.052–1.894) to higher risk of hepatotoxicity vis-à-vis wild-type allele. Likewise, the other genetic models of NAT2 gene polymorphisms have also shown increased risk of hepatotoxicity. No evidence of publication bias was observed. These results suggest that genetic variants of NAT2 gene have significant role in isoniazid induced hepatotoxicity. Thus, NAT2 genotyping has the potential to improve the understanding of the drug–enzyme metabolic capacity and help in early predisposition of isoniazid-induced hepatotoxicity.
LncRNA HAND2-AS1 inhibits non-small cell lung cancer migration, invasion and maintains cell stemness through the interactions with TGF-β1
Authors: Miao Feng , Chen Ji , Shi Meng , Song Yang , Chen Zhiming , Pang Liewen
Published: December 2018

LncRNA HAND2-AS1 is characterized as a tumor suppressor involved in several types of malignancies, but its role in non-small cell lung cancer (NSCLC) is unknown. Our study was carried out to investigate the involvement of lncRNA HAND2-AS1 in NSCLC. In our study, we observed that levels of HAND2-AS1 were lower in tumor tissues than that in adjacent healthy tissues. Compared with healthy controls, plasma levels of HAND2-AS1 were lower, while levels of transforming growth factor β (TGF-β) were higher in NSCLC patients. A significant negative correlation between plasma levels of HAND2-AS1 and TGF-β1 was found in NSCLC patients but not in healthy controls. LncRNA HAND2-AS1 overexpression inhibits, while exogenous TGF-β1 treatment promotes cell migration and invasion ability and cancer cell stemness. Cancer cells with lncRNA HAND2-AS1 overexpression showed down-regulated TGF-β1, while TGF-β1 treatment showed no significant effects on lncRNA HAND2-AS1 expression. TGF-β1 attenuated the inhibitory effects of lncRNA HAND2-AS1 overexpression on cell migration, invasion and stemness. We concluded that lncRNA HAND2-AS1 may regulate the migration, invasion and stemness of NSCLC cells through interactions with TGF-β1.
LabVIEW based measurements and control system of a micro-ORC installation with Scroll Expander
Authors: Eicke Albrecht , Smolen Sławomir
Published: December 2018

An innovative ORC-installation with a scroll engine as expansion device has been developed and designed at the City University of Applied Sciences in Bremen. This new transportable installation has the specific capability to be connected to an alternative power source, such as solar power. Pentafluoropropane (R245fa) has been selected as the working fluid because it is suitable for the required temperature ranges and exhibits some additional advantages related to this specific application. The details of the ORC-Cycle have been presented in another paper and are not the main topic of the presented work. The core matter of this paper is the measurement and control system of the installation, which enables the thermodynamic evaluation of the obtained experimental data, some back coupling, and control tasks. The data acquisition and matching procedure, connected with the operational measurement system, identifies the aggregate and operational states of working fluid in characteristic points of the thermodynamic cycle. The algorithm for searching for the points from the table of parameters take so much time, that the control loop cannot work correctly in time. This problem was solved with the producer-consumer architecture in LabVIEW. Data acquisition and quick response in the control loops are done in the producer-while loop. To reduce the number of values, data are written only every five seconds in a queue. From this queue the consumer-while loop reads values, if the computer has enough capacity. This technique ensures that no data are lost. The matching procedure searches in the parameter file for the thermal properties and displays the cycle in a T-s diagram. Some simple calculation procedures make it possible to evaluate the thermal efficiency and other cycle parameters while operating. At the end of this sequence, the data are saved in a file. In the next step, the producer-loop is executed directly in a Field Programmable Gate Array, so that the control can be executed stand-alone and the computer is only used for visualization.
Power to X – green hydrogen for electrical energy and fuel, for production and products
Authors: Lehmann Jochen , Luschtinetz Thomas , Gulden Johannes
Published: December 2018

Basing on the figure “Power to Hydrogen / Power to Gas”, shown by the authors at the last HTRSE conference, this time it will be illustrated, that green hydrogen - produced with renewable energy - has the potential to become a basic material in the economy at general instead of fossil one. Synergies are available. But the low price of hydrogen produced via steam reformation of natural gas prevents to reach business cases for environment friendly products as long as the European laws and regulations do not support production and use of green hydrogen for instance by a tax for CO2 emission.
Multi-objective optimization of ORC geothermal conversion system integrated with life cycle assessment
Authors: Matuszewska Dominika , Kuta Marta , Górski Jan
Published: December 2018

This paper details the development of a systematic methodology to integrated life cycle assessment (LCA) with thermo-economic models and to thereby identify the optimal exploitation schemes of geothermal resources. Overall geothermal systems consist of a superstructure of geothermal exploitable resources, a superstructure of conversion technology and multiple demand profiles for Swiss city. In this paper, an enhanced geothermal system has been chosen as exploitable resources. The energy conversion technology used in modelling is an organic Rankine cycle, which can be used to supply heat and electricity. In the Swiss case four demand profiles periods are considered: summer, interseason, winter and extreme winter, the city Nyon serving for the example case study. The multi-objective optimization system, that uses an evolutionary algorithm, is employed to determine the optimal scheme for some of the prepared models, with exergy efficiency and environmental impact as objectives.
Experimental investigation of forced convection of water/EG-Al2O3 nanofluids inside horizontal tube
Authors: Cieśliński Janusz T. , Kozak Przemysław
Published: December 2018

In this paper, forced convection of water/EG-Al2O3 nanofluids inside horizontal stainless steel tube is studied experimentally. As base fluid served water/EG mixture of two ratios (60:50 and 50:50). Nanoparticle mass concentrations was 0.1% or and 1%. Transition and turbulent flow regimes were tested. Average heat transfer coefficient and pressure drop values were determined for nanofluids and compared to base fluids. Deterioration of heat transfer for all tested nanofluids has been recorded compared to base fluid. Negligible increase of pressure drop for nanofluids compared to base fluids has been observed.
Boiling of a refrigerant of low GWP on the surface with copper microchannels
Authors: Kaniowski Robert , Pastuszko Robert
Published: December 2018

The boiling curves and heat transfer coefficients between the heating surface and fluid were investigated in the paper. Copper samples with horizontal microchannels of rectangular cross-section, variable depth and width were the objects of the study. The following geometrical parameters have been used: microchannel width 0.2; 0.3 and 0.4 mm, depth between 0.2 and 0.5 mm (change every 0.1 mm). Boiling refrigerant was Novec-649 (GWP = 1), and the experiment was performed at atmospheric pressure. Geometrical parameters impact, within a given range of heat flux 3 – 130 kW/m2, on the heat transfer process was determined.
Bubble departure diameter determination for pool boiling on surface with microchannels
Authors: Kaniowski Robert , Pastuszko Robert , Kowalczyk Joanna , Nowakowski Łukasz
Published: December 2018

The paper presents visualization investigations into pool boiling heat transfer for open microchannel surfaces. The experiments were carried out with saturated water, ethanol, FC-72 and Novec-649 at atmospheric pressure. Parallel microchannels fabricated by machining copper sample were about 0.2 to 0.5 mm wide and 0.2 to 0.5 mm deep. The diameter of departing bubble was calculated for the microchannel surface on the basis of buoyancy force and surface tension force balance. The visualization carried out was aimed at determining the diameters of the departing bubbles at various heat fluxes for four working fluids.
Selected thermal and flow issues in a reversed thermosiphon with a steam liquid lifter
Authors: Klugmann Michał , Dąbrowski Paweł , Mikielewicz Dariusz
Published: December 2018

The work presents initial studies of a reversed thermosiphon with a steam liquid lifter and a minigap evaporator. The main interest of the authors is the evaporator, especially the heat exchange efficiency and flow issues, such as maldistribution and pressure drop. However, because the thermosiphon circuit of such a construction is characterized by cyclic working conditions, which are quite difficult in analysis the authors focused on this specificity first. The article presents the concept of a test circuit and preliminary results for distilled water and for a minigap evaporator with a smooth heat exchange surface 100 x 200 mm and minigap thickness of 1 mm. Visualizations of the separator's work and the minigap boiling structures are presented.
Evaluation of energy effects of the heat distribution network modernization
Authors: Kujawa Tomasz , Stachel Aleksander
Published: December 2018

The work concerns the estimation of energy effects of modernization of a part of an existing heat distribution main, which is part of a system that supplies heat for heating and domestic hot water preparation. The energy effect was defined as the difference between heat losses in the installation previously operated, developed in the technology of traditionally insulated pipes placed in dedicated underground channels and newly built installations made of pre-insulated pipes located directly in the ground. In the paper, in a synthetic way, the method of calculation is presented, as well as the accompanying assumptions. Two basic approaches to determine the heat losses are discussed. The first one was based on detailed calculations based on real operational data, whereas the second one used the indicative method recommended by the National Fund for Environmental Protection and Water Management (NFOŚiGW). The results obtained on this basis show that the modernization of the installation returns measurable energy effects in the form of reduced heat losses, which translates into the efficiency of its operation and operation of the source. At the same time, they show that the size of obtained energy effect depends on the applied methodology of calculations.
Numerical modelling of natural convection in a square cavity: effect of nanofluid volume fraction and inclination
Authors: Charafi M.M. , Bendaraa A. , Hasnaoui A.
Published: December 2018

In this paper, the phenomenon of natural convection in a square cavity filled with copper (Cu) -based nanofluid (Nf) has been studied. The influences of the volume fraction (ф) on the convective flow, as well as the effect of the inclination (γ) of the cavity on thermal performances were examined. The dimensionless governing equations formulated using stream function, vorticity, and temperatures were solved by finite difference methods, where the Successive Over-Relaxation (SOR) iteration and the upwind scheme were adopted. The developed code served as a verification of results where it showed a good agreement with previous works. The calculation code was then used to visualize the influence of the inclination on the thermal enhancement and showed that the transfer becomes more efficient with an inclination of π/6.
The dynamics of HIV infection model with logistic growth and infected cells in eclipse phase
Authors: Harroudi Sanaa , Allali Karam
Published: December 2018

In this paper, we study a mathematical model of human immunodeficiency virus dynamics with logistic growth and infected cells in eclipse phase. This model describes the interactions between uninfected CD4+ T cells, infected CD4+ T cells in latent stage, productively infected CD4+ T cells and free virus. The positivity and boundedness of solutions for non negative initial data are proved. The stability of disease-free equilibrium and endemic equilibrium are rigorously established. Numerical simulations are also provided to give a more complete representation of the system dynamics.
Nonlinear Dynamics of a Planar Hinged-Supported Beam with One End Lumped Mass and Longitudinal Elastic Support
Authors: Kloda Lukasz , Lenci Stefano , Warminski Jerzy
Published: December 2018

Nonlinear forced-damped oscillations of a non-slender hinged simply supported beam with mass and spring attached to one end are investigated by mean of a finite element method. The frequency response curves are constructed numerically and the variability of hardening/softening behaviour of frequency response curves due to the lumped mass and axial linear spring stiffness is investigated. Resonant and sub resonant motion of beam midpoint as well as jumps between solution branches are highlighted.
A Meshfree Method for Heat Explosion Problems with Natural Convection in Inclined Porous Media
Authors: Halassi Abdoulhafar , Joundy Youssef , Salhi Loubna , Taik Ahmed
Published: December 2018

This paper investigates the interaction between natural convection and heat explosion in porous media. A meshless collocation method based on multiquadric radial basis functions has been applied to study the problem in an inclined two-dimensional porous media. The governing equations consist of coupling the Darcy equations in the Boussinesq approximation of low density variations to the heat equation with a nonlinear chemical source term. The numerical results obtained are in good agreement with some previous studies that consider the vertical direction. A complex behaviour of solutions is observed, including periodic and aperiodic oscillations. We have shown that a small inclination of the container stabilizes the reactive fluid and can prevent thermal explosion.
Analysis of dynamics of a vertical cantilever in rotary coupling to the moving frame with movement limiters
Authors: Wolszczak Piotr , Litak Grzegorz , Lygas Krystian
Published: December 2018

The efficiency of the mechanical energy harvesting with the use of vibrating elements can be improved by synchronizing stimulation vibrations and own linear frequencies of systems as well as super or sub harmonics induced by non-linear phenomena. The article presents numerical cross-sectional study of the mechanical system. The system consists of an elastic beam set vertically, which the lower end is fixed in the rotary support, and is stimulated to move in the horizontal axis. The upper end of the beam is free but below its level there are bumpers limiting the free rotation of the beam. Numerical studies took into account the variability of the frequency and amplitude of the excitation beam movement, and horizontal distance between bumpers. Beam deflection was observed, on the basis of which the amount of energy generated by the piezo element was estimated. Nonlinear phenomena and analysis of frequency synchronization of vibrations improving the energy effect of an energy generator are presented.
The control system of the yeast drying process
Authors: Wolszczak Piotr , Samociuk Waldemar
Published: December 2018

The article presents the results of choosing how to control a real non-linear object. Yeast drying requires a precise temperature control due to the possibility of overheating. The object changes properties during of the process flow. Object identification is used and a mathematical model is developed. The model is used to select roboust control methods. The results are compared to the system of two PID regulators used in practice.
Une analyse formelle du jeu des acteurs autour du projet de barrage de Sivens
Authors: Sibertin-Blanc Christophe
Published: December 2018

Le pays a été stupéfait d’apprendre la mort d’un opposant à la construction d’un barrage dans la forêt de Sivens, dans le Tarn, lors d’affrontements avec les forces de l’ordre dans la nuit du 25 au 26 octobre 2014. Pourtant, l’importance des moyens déployés pour réaliser cet ouvrage et la détermination des opposants, conjuguées au jeu de l’ensemble des parties prenantes de ce projet, laissaient présager la possibilité d’un tel drame. À l’aide d’une grille d’analyse formelle fondée sur la sociologie de l’action organisée, nous présentons un modèle de ce jeu d’acteurs dont les résultats de simulation mettent en évidence le caractère surdéterminé de l’émergence d’un conflit d’une extrême intensité. Des variations de ce modèle permettent ensuite de dégager les principaux déterminants de ce conflit et d’envisager un autre futur possible.
Selected aspects of corporate social responsibility in maritime freight services on the example of selected courier companies
Authors: Budziewicz-Guźlecka Agnieszka , Drab-Kurowska Anna
Published: December 2018

The aim of the article is to present the activities of corporate social responsibility in the CEP industry, with particular emphasis on maritime freight services. The article will present good practices and environmental activities proposed by the leaders of the CEP industry. An example may be the new "green services" of sea freight, which allow for reduction of CO2 emissions. The article puts forward the following research hypothesis - Raising awareness in the CSR area in the CEP industry will allow the implementation of environmental activities. In reference to the assumed goal and the hypothesis adopted in the article, the following research question was posed - what specific CSR implementation tools should be adopted by the CEP industry to actively shape environmental activities in maritime freight services? In an attempt to answer the question, the article first addressed the aspects of corporate social responsibility at CSR 3.0 level. Next, the focus was on presenting the results of the analysis of the maritime freight services offered by the leaders of the CEP industry. The following research methods were used in the article: method of critical analysis of literature, method of observing the proceedings of the entities examined, logical inference method, method of analysis and synthesis.The key element of the article is the presentation of proposals for actions aimed at intensifying activities strengthening maritime transport services through activities in the area of CSR.
Container terminals competitive factors – results of an international survey
Authors: Kaliszewski Adam , Kozłowski Arkadiusz , Dąbrowski Janusz , Klimek Hanna
Published: December 2018

Container terminals require continuous benchmarking of competitiveness factors. This paper discusses factors of competitiveness with a main focus on feeder and mixed terminals (in which both feeder and transshipment services are provided). Method statement includes an economic literature review with respect to competitiveness factors and a container port expert survey process to achieve a list of most important factors among global container port operators. Experts were selected from different countries and private container terminals. A questionnaire was developed and sent online to them. Questions required both a ranking of factors as well as assigning monetary values to critical variables. Responses were analyzed using a pre-established strategy. Overall, experts ranked first the role of market related competitiveness factors related to service quality, price level and adaptability to the changing market environment. Intermodal links and general hinterland connections factors were more often mentioned than factors relating to nautical accessibility or other factors. Both assignment of monetary values as well as ranking have produced mutually coherent results. The paper does not claim to be definitive; it aims to provide an update of competitive factors hierarchy and highlights issues for further port development.
Multi-use of the sea: from research to practice
Authors: Przedrzymirska Joanna , Zaucha Jacek , Depellgrin Daniel , Fairgrieve Rhona , Kafas Andronikos , Calado Helena Maria Gregório Pina , de Sousa Vergílio Marta Horta , Varona Mario Cana , Lazić Marija , Schultz-Zehden Angela , Papaioannou Eva , Bocci Martina , Läkamp Rianne , Giannelos Ioannis , Kovacheva Aneta , Buck Bella
Published: December 2018

The increasing demand for ocean resources exerts an increasing pressure on the use of ocean space across all European Sea Basins. This underlines issues of compatibility (or conflicts) between different maritime uses as well as between economic activities and environmental protection. The idea of multi-use (MU), as a guiding concept for efficient allocation of compatible activities in the same marine space, can increase spatial efficiency and at the same time provide socio-economic and environmental benefits. However, its transition from a concept to real-world development is facing several barriers. Based on analysis of five European sea basins done under the Horizon 2020 MUSES project (Multi-Use in European Seas), this paper aims to clarify the concept of MU by discussing: 1) the definition in the literature and practice so far, and; 2) how existing regulatory and planning regimes are supporting and challenging the development of several MUs (considered as the most promising). The analytical methodology developed for the MUSES project relied on data collected via desk research and semi structured interviews with key stakeholders (e.g. industry, regulators), over the period of seven months. The semi-quantitative analysis of data conducted, identified the commonalities and differences among countries in respect to each of the analyzed MUs. The paper points out priorities for the MU development in different sea basins and recommends initial steps to overcome existing barriers, whilst maximizing local benefits. This paper is a starting point towards a broader scientific debate on: (i) what could be the role of management policies (like for instance maritime spatial planning - MSP) in supporting and fostering MU concept development, (ii) what are technical and technological challenges for technically advanced MUs, (iii) how added values of MUs concept (e.g. benefits for local economies, positive impacts on environment) could be enhanced.
The competitiveness of ferry and air transport in the Baltic Sea Region: infrastructure approach
Authors: Mańkowska Marta , Tłoczyński Dariusz
Published: December 2018

The main aim of the article is attempt to get the answer to the question about the impact of services offered by point elements of transport infrastructure on meeting the expectations and preferences of passengers in various modes of transport. Based on the presented objective, the assessment of the competitiveness of air and ferry transport in the service of passenger traffic was carried out through taking into the consideration selected elements affecting the quality of services offered by airports and ferry terminals. One of the key factors of the competitiveness of ports is time availability. The main objective of the research undertaken in the article was therefore to assess the competitiveness of seaports and airports in terms of their time availability. The article uses the case study method of selected airports and ferry terminals located in the Baltic Sea Region (BSR). The comparative analysis covered the time competitiveness of port ground access. The results of the research allow to make a general conclusion that ferry terminals have better ground access for individual car journeys and airports are becoming more competitive in the case of the arrival and departure function of public transport. This indicates that the system of ground access for seaports and airports is adapted to the segment of passengers having the largest share in transport by the analyzed transport branches, i.e. the motorized passengers in ferry transport and non-motorized passengers in air transport.
Challenges for Polish ferry market development in Baltic Sea Region
Authors: Urbanyi-Popiołek Ilona
Published: December 2018

Polish ferry market has become one of the prime segments of ferry shipping in Baltic Sea Region. It dominates in ferry industry in South Baltic. The ferry cargo and passenger traffic has been growing steadily since Poland’s accession to the European Union. The estimates show that in 2017 the operators transported more than 1,2 million passengers and over 520 thousand cargo vehicles between ports in Poland and Sweden. The increase in trade turnover between Scandinavia and Central Europe as well as growth of tourism affect the demand for ferry transport. The aim of this paper is to explore the prime determinants influencing the development of Polish ferry shipping and to research the challenges that carriers operating the ferry services from Poland to Sweden must face such as internal competition between the operators in Polish market, competition from German and Lithuanian routes and low cost airlines as well as increasing trade volumes. The research hypothesis is: the growth of trade between Scandinavia and Central Europe as well as tourism traffic will increase the demand for ferry transport from Polish ports. Detailed research hypotheses are that: ferry services between Poland and Sweden constitute the primary market on the South Baltic and new tonnage investments to increase the capacity have to be taken.