bluuebunny/crossref_metadata_2025 huggingface dataset:
Supplementary Tables 1-2 from Targeting Truncated Retinoid X Receptor-α by CF31 Induces TNF-α–Dependent Apoptosis
Authors: Wang Guang-Hui , Jiang Fu-Quan , Duan Ying-Hui , Zeng Zhi-Ping , Chen Fan , Dai Yi , Chen Jie-Bo , Liu Jin-Xing , Liu Jie , Zhou Hu , Chen Hai-Feng , Zeng Jin-Zhang , Su Ying , Yao Xin-Sheng , Zhang Xiao-Kun
Published: March 2023

PDF file - 44K, S1. The predicted truncated merlin protein was not detected in Ben-Men-1 cells. S2. IC50 determination of AR-42 in normal meningeal cells. S3. AR-42 treatment increased protein acetylation and decreased p-AKT. S4. Normal meningeal cells proliferate with a doubling time of about three days. S5. Ben-Men-1-LucB and parental Ben-Men-1 cells exhibit similar sensitivities to AR-42. S6. Intracranial NF2-deficient KT21-MG1 xenograft tumors demonstrated features of malignant meningiomas. S7. Ben-Men-1-LucB xenografts strongly expressed vimentin, amesenchymal marker for meningiomas. S8. AR-42 treatment caused tumor regression, whereas AR-12 treatment slowed tumor growth over time. S9. MRI detected a small tumor in a Ben-Men-1-LucB tumorbearing mouse treated with AR-42 for three months. S10. MRI did not detect the residual tumor in an AR-42-treated mouse after removal from AR-42 diet for six months.
Supplemental Video 2 from Interstitial Flow in a 3D Microenvironment Increases Glioma Invasion by a CXCR4-Dependent Mechanism
Authors: Munson Jennifer M. , Bellamkonda Ravi V. , Swartz Melody A.
Published: March 2023

Supplemental Video 2 AVI file - 2041K, Glioma under flow
Supplemental Video 1 from Interstitial Flow in a 3D Microenvironment Increases Glioma Invasion by a CXCR4-Dependent Mechanism
Authors: Munson Jennifer M. , Bellamkonda Ravi V. , Swartz Melody A.
Published: March 2023

Supplemental Video 1 AVI file - 2214K, Glioma in static
Supplemental Figures from Interstitial Flow in a 3D Microenvironment Increases Glioma Invasion by a CXCR4-Dependent Mechanism
Authors: Munson Jennifer M. , Bellamkonda Ravi V. , Swartz Melody A.
Published: March 2023

Supplemental Figures PDF file - 346K, Supplementary figures to the main text
Supplementary Table 2 from TIG1 Promotes the Development and Progression of Inflammatory Breast Cancer through Activation of Axl Kinase
Authors: Wang Xiaoping , Saso Hitomi , Iwamoto Takayuki , Xia Weiya , Gong Yun , Pusztai Lajos , Woodward Wendy A. , Reuben James M. , Warner Steven L. , Bearss David J. , Hortobagyi Gabriel N. , Hung Mien-Chie , Ueno Naoto T.
Published: March 2023

PDF file, 72K, Candidate functional partners of TIG1 selected using DNA microarray analysis.
Supplementary Table 1 from TIG1 Promotes the Development and Progression of Inflammatory Breast Cancer through Activation of Axl Kinase
Authors: Wang Xiaoping , Saso Hitomi , Iwamoto Takayuki , Xia Weiya , Gong Yun , Pusztai Lajos , Woodward Wendy A. , Reuben James M. , Warner Steven L. , Bearss David J. , Hortobagyi Gabriel N. , Hung Mien-Chie , Ueno Naoto T.
Published: March 2023

PDF file, 76K, Relation between TIG1 expression status and clinicopathologic factors of the IBC patient tissues.
Supplementary Table 1 from EPR Oxygen Images Predict Tumor Control by a 50% Tumor Control Radiation Dose
Authors: Elas Martyna , Magwood Jessica M. , Butler Brandi , Li Chanel , Wardak Rona , DeVries Rebekah , Barth Eugene D. , Epel Boris , Rubinstein Samuel , Pelizzari Charles A. , Weichselbaum Ralph R. , Halpern Howard J.
Published: March 2023

PDF file, 40K, Dose given to MCa4 tumors vs HF10 before the radiation. MCa4 tumors of approximately the same size were treated with a range of 60-80 Gy, which is a narrow range around TCD50 value of 69 Gy consistent with the literature (Stone, 1975).
Supplementary Methods from Crizotinib Inhibits Metabolic Inactivation of Gemcitabine in c-Met–driven Pancreatic Carcinoma
Authors: Avan Amir , Caretti Viola , Funel Niccola , Galvani Elena , Maftouh Mina , Honeywell Richard J. , Lagerweij Tonny , Van Tellingen Olaf , Campani Daniela , Fuchs Dieter , Verheul Henk M. , Schuurhuis Gerrit-Jan , Boggi Ugo , Peters Godefridus J. , Würdinger Thomas , Giovannetti Elisa
Published: March 2023

PDF file - 155K, Description of additional methods and procedures used in the study. Also includes supplemental references.
Supplementary Figure Legend from Crizotinib Inhibits Metabolic Inactivation of Gemcitabine in c-Met–driven Pancreatic Carcinoma
Authors: Avan Amir , Caretti Viola , Funel Niccola , Galvani Elena , Maftouh Mina , Honeywell Richard J. , Lagerweij Tonny , Van Tellingen Olaf , Campani Daniela , Fuchs Dieter , Verheul Henk M. , Schuurhuis Gerrit-Jan , Boggi Ugo , Peters Godefridus J. , Würdinger Thomas , Giovannetti Elisa
Published: March 2023

PDF file - 129K
Supplementary Table 7 from Hallmarks of Aromatase Inhibitor Drug Resistance Revealed by Epigenetic Profiling in Breast Cancer
Authors: Jansen Maurice P.H.M. , Knijnenburg Theo , Reijm Esther A. , Simon Iris , Kerkhoven Ron , Droog Marjolein , Velds Arno , van Laere Steven , Dirix Luc , Alexi Xanthippi , Foekens John A. , Wessels Lodewyk , Linn Sabine C. , Berns Els M.J.J. , Zwart Wilbert
Published: March 2023

PDF file - 69K, Supplementary Table S7 Gene Ontology (GO) pathway enrichment for genes proximal to differentially enriched ERalpha, H3K4me3 and H3K27me3 binding events.
Supplementary Figure 8 from Crizotinib Inhibits Metabolic Inactivation of Gemcitabine in c-Met–driven Pancreatic Carcinoma
Authors: Avan Amir , Caretti Viola , Funel Niccola , Galvani Elena , Maftouh Mina , Honeywell Richard J. , Lagerweij Tonny , Van Tellingen Olaf , Campani Daniela , Fuchs Dieter , Verheul Henk M. , Schuurhuis Gerrit-Jan , Boggi Ugo , Peters Godefridus J. , Würdinger Thomas , Giovannetti Elisa
Published: March 2023

PDF file - 42K, Concentrations of crizotinib and gemcitabine in blood samples.
Supplementary Table 5 from Hallmarks of Aromatase Inhibitor Drug Resistance Revealed by Epigenetic Profiling in Breast Cancer
Authors: Jansen Maurice P.H.M. , Knijnenburg Theo , Reijm Esther A. , Simon Iris , Kerkhoven Ron , Droog Marjolein , Velds Arno , van Laere Steven , Dirix Luc , Alexi Xanthippi , Foekens John A. , Wessels Lodewyk , Linn Sabine C. , Berns Els M.J.J. , Zwart Wilbert
Published: March 2023

PDF file - 39K, Supplementary Table S5 QPCR primer sequences for 'good outcome' and 'poor outcome' enriched peaks for ERalpha, H3K4me3 and H3K27me3.
Supplementary Figure 5 from Crizotinib Inhibits Metabolic Inactivation of Gemcitabine in c-Met–driven Pancreatic Carcinoma
Authors: Avan Amir , Caretti Viola , Funel Niccola , Galvani Elena , Maftouh Mina , Honeywell Richard J. , Lagerweij Tonny , Van Tellingen Olaf , Campani Daniela , Fuchs Dieter , Verheul Henk M. , Schuurhuis Gerrit-Jan , Boggi Ugo , Peters Godefridus J. , Würdinger Thomas , Giovannetti Elisa
Published: March 2023

PDF file - 40K, HGF expression.
Supplementary Table 3 from Hallmarks of Aromatase Inhibitor Drug Resistance Revealed by Epigenetic Profiling in Breast Cancer
Authors: Jansen Maurice P.H.M. , Knijnenburg Theo , Reijm Esther A. , Simon Iris , Kerkhoven Ron , Droog Marjolein , Velds Arno , van Laere Steven , Dirix Luc , Alexi Xanthippi , Foekens John A. , Wessels Lodewyk , Linn Sabine C. , Berns Els M.J.J. , Zwart Wilbert
Published: March 2023

PDF file - 56K, Supplementary Table S3 Read count, filtering and number of peaks.
Supplementary Figure 3 from Crizotinib Inhibits Metabolic Inactivation of Gemcitabine in c-Met–driven Pancreatic Carcinoma
Authors: Avan Amir , Caretti Viola , Funel Niccola , Galvani Elena , Maftouh Mina , Honeywell Richard J. , Lagerweij Tonny , Van Tellingen Olaf , Campani Daniela , Fuchs Dieter , Verheul Henk M. , Schuurhuis Gerrit-Jan , Boggi Ugo , Peters Godefridus J. , Würdinger Thomas , Giovannetti Elisa
Published: March 2023

PDF file - 189K, H&E and IHC staining demonstrating the human origin of the PDAC-FM-GC mouse models.
Supplementary Table 10 from Hallmarks of Aromatase Inhibitor Drug Resistance Revealed by Epigenetic Profiling in Breast Cancer
Authors: Jansen Maurice P.H.M. , Knijnenburg Theo , Reijm Esther A. , Simon Iris , Kerkhoven Ron , Droog Marjolein , Velds Arno , van Laere Steven , Dirix Luc , Alexi Xanthippi , Foekens John A. , Wessels Lodewyk , Linn Sabine C. , Berns Els M.J.J. , Zwart Wilbert
Published: March 2023

PDF file - 143K, Supplementary Table S10 ChIP-seq data integration with ENCODE datasets.
Supplementary Figure 5 from Hallmarks of Aromatase Inhibitor Drug Resistance Revealed by Epigenetic Profiling in Breast Cancer
Authors: Jansen Maurice P.H.M. , Knijnenburg Theo , Reijm Esther A. , Simon Iris , Kerkhoven Ron , Droog Marjolein , Velds Arno , van Laere Steven , Dirix Luc , Alexi Xanthippi , Foekens John A. , Wessels Lodewyk , Linn Sabine C. , Berns Els M.J.J. , Zwart Wilbert
Published: March 2023

PDF file - 101K, Supplementary Figure S5 Venn diagram, depicting the level of overlap of genes between 'proximity' and 'functionality' genes.
Supplementary Figure 3 from miR-153 Supports Colorectal Cancer Progression via Pleiotropic Effects That Enhance Invasion and Chemotherapeutic Resistance
Authors: Zhang Lei , Pickard Karen , Jenei Veronika , Bullock Marc D. , Bruce Amanda , Mitter Richard , Kelly Gavin , Paraskeva Christos , Strefford John , Primrose John , Thomas Gareth J. , Packham Graham , Mirnezami Alex H.
Published: March 2023

PDF file, 5326K, Copy number change in miR-153.
Supplementary Table 2 from Stress-Response Protein RBM3 Attenuates the Stem-like Properties of Prostate Cancer Cells by Interfering with CD44 Variant Splicing
Authors: Zeng Yu , Wodzenski Dana , Gao Dong , Shiraishi Takumi , Terada Naoki , Li Youqiang , Vander Griend Donald J. , Luo Jun , Kong Chuize , Getzenberg Robert H. , Kulkarni Prakash
Published: March 2023

Supplementary Table 2 - PDF file 33K, Calculated size of PCR products for CD44 splicing variants
Supplementary Figure 3 from Stress-Response Protein RBM3 Attenuates the Stem-like Properties of Prostate Cancer Cells by Interfering with CD44 Variant Splicing
Authors: Zeng Yu , Wodzenski Dana , Gao Dong , Shiraishi Takumi , Terada Naoki , Li Youqiang , Vander Griend Donald J. , Luo Jun , Kong Chuize , Getzenberg Robert H. , Kulkarni Prakash
Published: March 2023

Supplementary Figure 3 - PDF file 244K, (A), CD44 variant mRNAs were amplified by PCR using the general primers c13 and hs3'. The PCR products at size of 650 bp and 250 bp were cut and subjected to direct DNA sequencing. The numbers in the block are exons number of CD44. N, negative control; G#1, PC3-GFP-clone #1. (B), schematic diagram of designing siRNAs specific to CD 44 variant exons v8-v10 (siC1, siC2) and primers specific to CD44v8-v10 (CD44v) or standard CD44 (CD44s). Primers c13 and hs3' can amplify both CD44s and CD44v. Primers p1 and p2 can only amplify CD44v8-v10, while primers p3 and p4 are specific to standard CD44s. Primer hs5' is the outside primer of the nest PCR. (C), the specificity of siRNAs targeting for CD44v8-v10. Variant exon-specific PCR was performed using primer p1 and p2. CD44s was amplified using CD44 standard-specific primer p3 and p4. siN, non-target siRNA. Data are mean � s.d. (n = 3), *P < 0.05. (D), the efficiency of siRNA pool targeting RBM3. Cells were treated with siRBM3 or non-targeting siRNA (siN) for 48 hr. The expression of mRNA and protein of CD44 were detected by RT-PCR and Western blot, respectively. R#1, PC3-RBM3-clone #1; R#6, PC3-RBM3-clone #6. Data are mean � s.d. (n = 3), *P < 0.05
Supplementary Figures from Akt SUMOylation Regulates Cell Proliferation and Tumorigenesis
Authors: Li Rong , Wei Jie , Jiang Cong , Liu Dongmei , Deng Lu , Zhang Kai , Wang Ping
Published: March 2023

PDF file, 739K, Fig. S1. SUMOylation of Akt. Fig.S2: Association of Akt with PIAS1 and SENP1. Fig. S3 Identification of SUMOylation site in Akt. Fig. S4 K168 and K183 is important to Akt SUMOylation. Fig. S5 SUMOylation affects the phosphorylation of FOXO proteins. Fig. S6. Mutation of K276 SUMOylation site does not affect its dimerization, association with substrates, and ubiquitination. Fig. S7. SUMOylation has little effect on Akt Subcellular Localization.
Supplementary Figure 6 from Constitutive HER2 Signaling Promotes Breast Cancer Metastasis through Cellular Senescence
Authors: Angelini Pier Davide , Fluck Mariano F. Zacarias , Pedersen Kim , Parra-Palau Josep Lluís , Guiu Marc , Bernadó Morales Cristina , Vicario Rocio , Luque-García Antonio , Navalpotro Nerea Peiró , Giralt Jordi , Canals Francesc , Gomis Roger R. , Tabernero Josep , Baselga José , Villanueva Josep , Arribas Joaquín
Published: March 2023

PDF file - 65K, Growth of a mixture 1:1 of MCF7 Tet-off / p95HER2 and MDA-MB-231 / Luc cells in the presence or absence of doxycycline
Supplementary Figure 5 from Constitutive HER2 Signaling Promotes Breast Cancer Metastasis through Cellular Senescence
Authors: Angelini Pier Davide , Fluck Mariano F. Zacarias , Pedersen Kim , Parra-Palau Josep Lluís , Guiu Marc , Bernadó Morales Cristina , Vicario Rocio , Luque-García Antonio , Navalpotro Nerea Peiró , Giralt Jordi , Canals Francesc , Gomis Roger R. , Tabernero Josep , Baselga José , Villanueva Josep , Arribas Joaquín
Published: March 2023

PDF file - 53K, The removal of doxycycline from the drinking water does not affect the metastatic growth of MDA-MB-231 cells
Supplementary Figure 5 from Neuropilin-2 Promotes Extravasation and Metastasis by Interacting with Endothelial α5 Integrin
Authors: Cao Ying , Hoeppner Luke H. , Bach Steven , E Guangqi , Guo Yan , Wang Enfeng , Wu Jianmin , Cowley Mark J. , Chang David K. , Waddell Nicola , Grimmond Sean M. , Biankin Andrew V. , Daly Roger J. , Zhang Xiaohui , Mukhopadhyay Debabrata
Published: March 2023

PDF file - 164K, Supplemental Fig. 5. The effect of NRP-2 knock down on ASPC-1 cell primary tumor growth and liver metastasis. A. NRP-2 knockdown did not significantly reduce ASPC-1 primary tumor growth. 2 x 106 control or NRP-2 shRNA ASPC-1 cells were injected into SCID mice pancreas, and after 15 days, tumor weight was analyzed. B. Total images of livers from control and NRP-2 knockdown ASPC-1 tumor burden mice. The ASPC-1 cells contain GFP and the GFP fluoresce signal in the liver was examined by IVIS Imaging System 200.
Supplementary Figure 4 from Constitutive HER2 Signaling Promotes Breast Cancer Metastasis through Cellular Senescence
Authors: Angelini Pier Davide , Fluck Mariano F. Zacarias , Pedersen Kim , Parra-Palau Josep Lluís , Guiu Marc , Bernadó Morales Cristina , Vicario Rocio , Luque-García Antonio , Navalpotro Nerea Peiró , Giralt Jordi , Canals Francesc , Gomis Roger R. , Tabernero Josep , Baselga José , Villanueva Josep , Arribas Joaquín
Published: March 2023

PDF file - 136K, Expression of p95HER2 leads to senescence in MCF7 cell xenografts
Supplementary Figure 2 from Nkx2-8 Downregulation Promotes Angiogenesis and Activates NF-κB in Esophageal Cancer
Authors: Lin Chuyong , Song Libing , Gong Hui , Liu Aibin , Lin Xi , Wu Jueheng , Li Mengfeng , Li Jun
Published: March 2023

PDF file - 89K, Downregulation of Nkx2-8 promotes ESCC angiogenesis in vivo.
Supplementary Figure 1 from Glutathione-Deficient Mice Have Increased Sensitivity to Transplacental Benzo[a]pyrene-Induced Premature Ovarian Failure and Ovarian Tumorigenesis
Authors: Lim Jinhwan , Lawson Gregory W. , Nakamura Brooke N. , Ortiz Laura , Hur Jin A. , Kavanagh Terrance J. , Luderer Ulrike
Published: March 2023

PDF file - 9.7MB, Hematoxylin and eosin stained sections of ovarian tumors in Gclm+/+ and Gclm-/- F1 females prenatally exposed to BaP
Supplementary Table 1 from Enhanced Radiation Sensitivity in HPV-Positive Head and Neck Cancer
Authors: Kimple Randall J. , Smith Molly A. , Blitzer Grace C. , Torres Alexandra D. , Martin Joshua A. , Yang Robert Z. , Peet Chimera R. , Lorenz Laurel D. , Nickel Kwangok P. , Klingelhutz Aloysius J. , Lambert Paul F. , Harari Paul M.
Published: March 2023

XLSX - 35K, Sources and culture conditions for cell lines.
Supplementary Figure 6 from Survivin-3B Potentiates Immune Escape in Cancer but Also Inhibits the Toxicity of Cancer Chemotherapy
Authors: Végran Frédérique , Mary Romain , Gibeaud Anne , Mirjolet Céline , Collin Bertrand , Oudot Alexandra , Charon-Barra Céline , Arnould Laurent , Lizard-Nacol Sarab , Boidot Romain
Published: March 2023

PDF file, 767K, S-3B protected cells from different cancer treatments.
Supplementary Information from Conditional Loss of ErbB3 Delays Mammary Gland Hyperplasia Induced by Mutant PIK3CA without Affecting Mammary Tumor Latency, Gene Expression, or Signaling
Authors: Young Christian D. , Pfefferle Adam D. , Owens Philip , Kuba María G. , Rexer Brent N. , Balko Justin M. , Sánchez Violeta , Cheng Hailing , Perou Charles M. , Zhao Jean J. , Cook Rebecca S. , Arteaga Carlos L.
Published: March 2023

Supplementary information - PDF file 2943K, Supplementary Figure 1: Dox-induced iPIK3.iCre transgenic mouse model of PIK3CA mutant breast cancer. Supplementary Figure 2: Loss of ErbB3 delays mammary gland hyperplasia at 12 weeks. Supplementary Figure 3: IVIS Bioluminescent imaging. Supplementary Figure 4: Histology of PIK3CA-induced mammary tumors remains diverse when ErbB3 is lost. Supplementary Figure 5: Mutant PI3K binds to IRS-1, Gab1 and other tyrosinephosphorylated proteins in tumors treated with lapatinib and/or imatinib. Supplementary Figure 6: Combination of BYL719 and lapatinib delays tumor growth without causing liver toxicity
Supplementary Figure Legends 1-2 from A Classification Model for BRCA2 DNA Binding Domain Missense Variants Based on Homology-Directed Repair Activity
Authors: Guidugli Lucia , Pankratz Vernon S. , Singh Namit , Thompson James , Erding Catherine A. , Engel Christoph , Schmutzler Rita , Domchek Susan , Nathanson Katherine , Radice Paolo , Singer Christian , Tonin Patricia N. , Lindor Noralane M. , Goldgar David E. , Couch Fergus J.
Published: March 2023

PDF file - 42K
Supplementary Figure 1 from A Classification Model for BRCA2 DNA Binding Domain Missense Variants Based on Homology-Directed Repair Activity
Authors: Guidugli Lucia , Pankratz Vernon S. , Singh Namit , Thompson James , Erding Catherine A. , Engel Christoph , Schmutzler Rita , Domchek Susan , Nathanson Katherine , Radice Paolo , Singer Christian , Tonin Patricia N. , Lindor Noralane M. , Goldgar David E. , Couch Fergus J.
Published: March 2023

PDF file - 863K, Western blots of ectopically expressed BRCA2 wildtype and VUS containing proteins
Supplementary Experimental Procedures and Figures and Tables from Cetuximab Attenuates Its Cytotoxic and Radiosensitizing Potential by Inducing Fibronectin Biosynthesis
Authors: Eke Iris , Storch Katja , Krause Mechthild , Cordes Nils
Published: March 2023

PDF file, 606K, Methods, Figures, Figure legends, Tables Fig. S1. A, EGFR protein expression in A549 and H1299 cells evaluated by Western blot. Fig. S2. A, A549 cells were cultured in the presence (+FCS) or absence (-FCS) of FCS and B, additionally treated with Cetuximab (5 microg/ml) for 24 h or 48 h. Fig. S3. Confocal fluorescence images of EGFR localization Fig. S4. Western blot analysis of A549 cells treated with Cetuximab Fig. S5. Immunofluorescence staining of CREB and phosphorylated CREB in A549 cells 48 h after treatment with Cetuximab Fig. S6. Promotor activity Table S1. List of Data sets Table S2. List of specific primers and probes.
Supplementary Figure 3 from Proinflammatory Homeobox Gene, ISX, Regulates Tumor Growth and Survival in Hepatocellular Carcinoma
Authors: Hsu Shih-Hsien , Wang Li-Ting , Lee King-Teh , Chen Yao-Li , Liu Kwei-Yan , Suen Jau-Ling , Chai Chee-Yin , Wang Shen-Nien
Published: March 2023

PDF file - 465K, The knock down activity of Isx expression by shRNAi in hepatocarcinoma cell lines.
Supplementary Table 4 from ALDH1-Positive Cancer Stem Cells Predict Engraftment of Primary Breast Tumors and Are Governed by a Common Stem Cell Program
Authors: Charafe-Jauffret Emmanuelle , Ginestier Christophe , Bertucci François , Cabaud Olivier , Wicinski Julien , Finetti Pascal , Josselin Emmanuelle , Adelaide José , Nguyen Tien-Tuan , Monville Florence , Jacquemier Jocelyne , Thomassin-Piana Jeanne , Pinna Guillaume , Jalaguier Aurélie , Lambaudie Eric , Houvenaeghel Gilles , Xerri Luc , Harel-Bellan Annick , Chaffanet Max , Viens Patrice , Birnbaum Daniel
Published: March 2023

Table SIII. Breast cancer stem cell gene expression signature (BCSC-GES)
Supplementary Figure 1 from Proinflammatory Homeobox Gene, ISX, Regulates Tumor Growth and Survival in Hepatocellular Carcinoma
Authors: Hsu Shih-Hsien , Wang Li-Ting , Lee King-Teh , Chen Yao-Li , Liu Kwei-Yan , Suen Jau-Ling , Chai Chee-Yin , Wang Shen-Nien
Published: March 2023

PDF file - 13K, The mRNA expression of IL-6 in HCC tumor species showed highly correlated expression with Isx mRNA expression.
Supplementary Table 3 from ALDH1-Positive Cancer Stem Cells Predict Engraftment of Primary Breast Tumors and Are Governed by a Common Stem Cell Program
Authors: Charafe-Jauffret Emmanuelle , Ginestier Christophe , Bertucci François , Cabaud Olivier , Wicinski Julien , Finetti Pascal , Josselin Emmanuelle , Adelaide José , Nguyen Tien-Tuan , Monville Florence , Jacquemier Jocelyne , Thomassin-Piana Jeanne , Pinna Guillaume , Jalaguier Aurélie , Lambaudie Eric , Houvenaeghel Gilles , Xerri Luc , Harel-Bellan Annick , Chaffanet Max , Viens Patrice , Birnbaum Daniel
Published: March 2023

Table SIII. Breast cancer stem cell gene expression signature (BCSC-GES)
Supplementary Table 1 from ALDH1-Positive Cancer Stem Cells Predict Engraftment of Primary Breast Tumors and Are Governed by a Common Stem Cell Program
Authors: Charafe-Jauffret Emmanuelle , Ginestier Christophe , Bertucci François , Cabaud Olivier , Wicinski Julien , Finetti Pascal , Josselin Emmanuelle , Adelaide José , Nguyen Tien-Tuan , Monville Florence , Jacquemier Jocelyne , Thomassin-Piana Jeanne , Pinna Guillaume , Jalaguier Aurélie , Lambaudie Eric , Houvenaeghel Gilles , Xerri Luc , Harel-Bellan Annick , Chaffanet Max , Viens Patrice , Birnbaum Daniel
Published: March 2023

Table SI. Histoclinical and molecular parameters of the 74 primary tumors injected
Supplementary Methods from ALDH1-Positive Cancer Stem Cells Predict Engraftment of Primary Breast Tumors and Are Governed by a Common Stem Cell Program
Authors: Charafe-Jauffret Emmanuelle , Ginestier Christophe , Bertucci François , Cabaud Olivier , Wicinski Julien , Finetti Pascal , Josselin Emmanuelle , Adelaide José , Nguyen Tien-Tuan , Monville Florence , Jacquemier Jocelyne , Thomassin-Piana Jeanne , Pinna Guillaume , Jalaguier Aurélie , Lambaudie Eric , Houvenaeghel Gilles , Xerri Luc , Harel-Bellan Annick , Chaffanet Max , Viens Patrice , Birnbaum Daniel
Published: March 2023

PDF file - 97K
Supplementary Methods and Figure Legends from ANTXR1, a Stem Cell-Enriched Functional Biomarker, Connects Collagen Signaling to Cancer Stem-like Cells and Metastasis in Breast Cancer
Authors: Chen Daohong , Bhat-Nakshatri Poornima , Goswami Chirayu , Badve Sunil , Nakshatri Harikrishna
Published: March 2023

PDF file, 87K.
Supplementary Figure Legends from ALDH1-Positive Cancer Stem Cells Predict Engraftment of Primary Breast Tumors and Are Governed by a Common Stem Cell Program
Authors: Charafe-Jauffret Emmanuelle , Ginestier Christophe , Bertucci François , Cabaud Olivier , Wicinski Julien , Finetti Pascal , Josselin Emmanuelle , Adelaide José , Nguyen Tien-Tuan , Monville Florence , Jacquemier Jocelyne , Thomassin-Piana Jeanne , Pinna Guillaume , Jalaguier Aurélie , Lambaudie Eric , Houvenaeghel Gilles , Xerri Luc , Harel-Bellan Annick , Chaffanet Max , Viens Patrice , Birnbaum Daniel
Published: March 2023

PDF file - 87K
Supplementary Figure 6 from ANTXR1, a Stem Cell-Enriched Functional Biomarker, Connects Collagen Signaling to Cancer Stem-like Cells and Metastasis in Breast Cancer
Authors: Chen Daohong , Bhat-Nakshatri Poornima , Goswami Chirayu , Badve Sunil , Nakshatri Harikrishna
Published: March 2023

PDF file, 2974K, Tumor growth rate of control and ANTXR1 knockdown cells.
Supplementary Figure 4 from ANTXR1, a Stem Cell-Enriched Functional Biomarker, Connects Collagen Signaling to Cancer Stem-like Cells and Metastasis in Breast Cancer
Authors: Chen Daohong , Bhat-Nakshatri Poornima , Goswami Chirayu , Badve Sunil , Nakshatri Harikrishna
Published: March 2023

PDF file, 3176K, Mammosphere formation by ANTXR1-positive cells.
Supplementary Materials and Methods from NF-κB Regulates Radioresistance Mediated By β1-Integrin in Three-Dimensional Culture of Breast Cancer Cells
Authors: Ahmed Kazi Mokim , Zhang Hui , Park Catherine C.
Published: March 2023

PDF File - 55K, Information regarding radiosensitivity and biochemical assays, immunoflouresence and immunohistochemistry methods, DNA-binding assays, in vivo studies and statistics.
Supplementary Figure 3 from ANTXR1, a Stem Cell-Enriched Functional Biomarker, Connects Collagen Signaling to Cancer Stem-like Cells and Metastasis in Breast Cancer
Authors: Chen Daohong , Bhat-Nakshatri Poornima , Goswami Chirayu , Badve Sunil , Nakshatri Harikrishna
Published: March 2023

PDF file, 3708K, Prognostic value of ANTXR1 and HSPA1A.
Supplementary Figure 4 from NF-κB Regulates Radioresistance Mediated By β1-Integrin in Three-Dimensional Culture of Breast Cancer Cells
Authors: Ahmed Kazi Mokim , Zhang Hui , Park Catherine C.
Published: March 2023

PDF File - 1444K, Interactions of �1-integrin with NF-�B p65 and �5-integrin were oppositely regulated in 3D lrECM in S1 and T4-2 cells after radiation.
Supplementary Figure 1 from ANTXR1, a Stem Cell-Enriched Functional Biomarker, Connects Collagen Signaling to Cancer Stem-like Cells and Metastasis in Breast Cancer
Authors: Chen Daohong , Bhat-Nakshatri Poornima , Goswami Chirayu , Badve Sunil , Nakshatri Harikrishna
Published: March 2023

PDF file, 5574K, ANTXR1 expression in breast cancer subtypes.
Supplementary Figures 1 - 9 from Hedgehog Signaling Alters Reliance on EGF Receptor Signaling and Mediates Anti-EGFR Therapeutic Resistance in Head and Neck Cancer
Authors: Keysar Stephen B. , Le Phuong N. , Anderson Ryan T. , Morton J. Jason , Bowles Daniel W. , Paylor Jeramiah J. , Vogler Brian W. , Thorburn Jackie , Fernandez Pamela , Glogowska Magdalena J. , Takimoto Sarah M. , Sehrt Daniel B. , Gan Gregory N. , Eagles-Soukup Justin R. , Serracino Hilary , Hirsch Fred R. , Lucia M. Scott , Thorburn Andrew , Song John I. , Wang Xiao-Jing , Jimeno Antonio
Published: March 2023

PDF file - 1255K, Confirmation of GLI1 modulation by EGFR activation (S1); Epithelial gene expression profile and morphology predicts erlotinib sensitivity in HNSCC cell lines (S2); Zeb1 transcription factor is key driver of EGF induced EMT (S3); EGFR activation induces EMT in HNSCC cell lines characterized by expression of Vimentin (S4); Inter-pathway crosstalk as well as EGF induced EMT are blunted in erlotinib resistant cells (S5); Silencing of HhP transcription factor GLI1 increases EGFR driven EMT in Tu-167 cells (S6); MEK/ERK signaling is required for EMT-like state while both MEK/ERK and PI3K/AKT are required for invasion through Matrigel (S7); Proliferative inhibition of erltotinib (1μM and 2μM) plus IPI-926 (1μM) or SHH (250ng/ml) (S8); Cetuximab and IPI-926 modulate EGFR, HhP and EMT gene expression in vivo (S9).
Supplementary Figure 2 from Breast Tumor Kinase (Brk/PTK6) Is a Mediator of Hypoxia-Associated Breast Cancer Progression
Authors: Regan Anderson Tarah M. , Peacock Danielle L. , Daniel Andrea R. , Hubbard Gregory K. , Lofgren Kristopher A. , Girard Brian J. , Schörg Alexandra , Hoogewijs David , Wenger Roland H. , Seagroves Tiffany N. , Lange Carol A.
Published: March 2023

PDF file, 3449K, ChIP data showing recruitment of HIF-1a, HIF-2a, and RNA pol II to HREs 2-5 in the Brk promoter.
Supplementary Figure 1 from Breast Tumor Kinase (Brk/PTK6) Is a Mediator of Hypoxia-Associated Breast Cancer Progression
Authors: Regan Anderson Tarah M. , Peacock Danielle L. , Daniel Andrea R. , Hubbard Gregory K. , Lofgren Kristopher A. , Girard Brian J. , Schörg Alexandra , Hoogewijs David , Wenger Roland H. , Seagroves Tiffany N. , Lange Carol A.
Published: March 2023

PDF file, 4524K, Regulation of Brk protein and mRNA expression in MCF7 cells.
Supplementary Table 1 from Mammary Tumor Formation and Metastasis Evoked by a HER2 Splice Variant
Authors: Alajati Abdullah , Sausgruber Nina , Aceto Nicola , Duss Stephan , Sarret Sophie , Voshol Hans , Bonenfant Debora , Bentires-Alj Mohamed
Published: March 2023

PDF file, 104K, List of peptides differentially phosphorylated in MCF10A-Delta-HER2 cells compared to WT-HER2.
Supplementary Table 2 from A Tumorigenic MLL-Homeobox Network in Human Glioblastoma Stem Cells
Authors: Gallo Marco , Ho Jenny , Coutinho Fiona J. , Vanner Robert , Lee Lilian , Head Renee , Ling Erick K. M. , Clarke Ian D. , Dirks Peter B.
Published: March 2023

PDF file - 855K, Human Fetal Neural Stem Cell Characteristics
Supplementary Figure Legend from Resistance to Irreversible EGF Receptor Tyrosine Kinase Inhibitors through a Multistep Mechanism Involving the IGF1R Pathway
Authors: Cortot Alexis B. , Repellin Claire E. , Shimamura Takeshi , Capelletti Marzia , Zejnullahu Kreshnik , Ercan Dalia , Christensen James G. , Wong Kwok-Kin , Gray Nathanael S. , Jänne Pasi A.
Published: March 2023

PDF file - 80K
Supplementary Figure 9 from A Tumorigenic MLL-Homeobox Network in Human Glioblastoma Stem Cells
Authors: Gallo Marco , Ho Jenny , Coutinho Fiona J. , Vanner Robert , Lee Lilian , Head Renee , Ling Erick K. M. , Clarke Ian D. , Dirks Peter B.
Published: March 2023

PDF file - 52K, Injections of different cell doses for G411NS and GliNS1 cells in mice
Supplementary Figure 6 from A Tumorigenic MLL-Homeobox Network in Human Glioblastoma Stem Cells
Authors: Gallo Marco , Ho Jenny , Coutinho Fiona J. , Vanner Robert , Lee Lilian , Head Renee , Ling Erick K. M. , Clarke Ian D. , Dirks Peter B.
Published: March 2023

PDF file - 1MB, Expression vs. copy number variation for HOXA10 in GBM samples
Supplementary Figure 5 from A Tumorigenic MLL-Homeobox Network in Human Glioblastoma Stem Cells
Authors: Gallo Marco , Ho Jenny , Coutinho Fiona J. , Vanner Robert , Lee Lilian , Head Renee , Ling Erick K. M. , Clarke Ian D. , Dirks Peter B.
Published: March 2023

PDF file - 3.2MB, Gene Ontology analysis of the 261 putative HOXA10 targets
Supplementary Figure 4 from Resistance to Irreversible EGF Receptor Tyrosine Kinase Inhibitors through a Multistep Mechanism Involving the IGF1R Pathway
Authors: Cortot Alexis B. , Repellin Claire E. , Shimamura Takeshi , Capelletti Marzia , Zejnullahu Kreshnik , Ercan Dalia , Christensen James G. , Wong Kwok-Kin , Gray Nathanael S. , Jänne Pasi A.
Published: March 2023

PDF file - 82K, PFR3 cells do not share the characteristics of "drug-tolerant cells"
Supplementary Figure 4 from A Tumorigenic MLL-Homeobox Network in Human Glioblastoma Stem Cells
Authors: Gallo Marco , Ho Jenny , Coutinho Fiona J. , Vanner Robert , Lee Lilian , Head Renee , Ling Erick K. M. , Clarke Ian D. , Dirks Peter B.
Published: March 2023

PDF file - 3.3MB, Chromatin immunoprecipitation with antibodies targeting the endogenous HOXA10 protein in G411NS
Supplementary Figure 1 from Resistance to Irreversible EGF Receptor Tyrosine Kinase Inhibitors through a Multistep Mechanism Involving the IGF1R Pathway
Authors: Cortot Alexis B. , Repellin Claire E. , Shimamura Takeshi , Capelletti Marzia , Zejnullahu Kreshnik , Ercan Dalia , Christensen James G. , Wong Kwok-Kin , Gray Nathanael S. , Jänne Pasi A.
Published: March 2023

PDF file - 578K, PI3K inhibition restores sensitivity to PF299804 and WZ4002
Supplementary Figure 2 from A Tumorigenic MLL-Homeobox Network in Human Glioblastoma Stem Cells
Authors: Gallo Marco , Ho Jenny , Coutinho Fiona J. , Vanner Robert , Lee Lilian , Head Renee , Ling Erick K. M. , Clarke Ian D. , Dirks Peter B.
Published: March 2023

PDF file - 538K, ChIP PCR Controls
Supplementary Tables 1 - 3 from Connective Tissue Growth Factor Activates Pluripotency Genes and Mesenchymal–Epithelial Transition in Head and Neck Cancer Cells
Authors: Chang Cheng-Chi , Hsu Wen-Hao , Wang Chen-Chien , Chou Chun-Hung , Kuo Mark Yen-Ping , Lin Been-Ren , Chen Szu-Ta , Tai Shyh-Kuan , Kuo Min-Liang , Yang Muh-Hwa
Published: March 2023

PDF file - 111K, Sequence of the oligonucleotides for siRNA construct-making, reverse transcription, real-time PCR, and qChIP assay (S1); List of proteins tested by antibodies and characteristics of the corresponding antibodies (S2); Clinical characteristics of 78 HNSCC cases (S3).
Supplementary Material from C-RAF Mutations Confer Resistance to RAF Inhibitors
Authors: Antony Rajee , Emery Caroline M. , Sawyer Allison M. , Garraway Levi A.
Published: March 2023

Supplementary Material - PDF file 1876K, Supplementary Figure S1. Characterization of mutants obtained from B-RAFV600E random mutagenesis screens Supplementary Figure S2. Biochemical characterization of C-RAF resistance alleles Supplementary Figure S3. Effects of MEK inhibition on C-RAF resistance mutants Supplementary Figure S4. 293/T cells coexpressing His/V5 tagged C-RAF resistance mutants with Flag tagged WT-C-RAF were immunoprecipitated after 48 h with His and levels of Flag tagged C-RAF interaction was assessed by immunoblotting. Input lysate represents Flag-C-RAF, V5-C-RAF, C-RAF, p-MEK, p-ERK and total ERK. Supplementary Figure S5. A model of the putative effects of pharmacological RAF inhibitors on C-RAF resistance alleles. Supplementary Figure S6. Integrated Genomics Viewer (IGV) image of a RAF1 mutation present in a primary melanoma tumor
Supplementary Figure S5 from Integration of High-Resolution Methylome and Transcriptome Analyses to Dissect Epigenomic Changes in Childhood Acute Lymphoblastic Leukemia
Authors: Busche Stephan , Ge Bing , Vidal Ramon , Spinella Jean-François , Saillour Virginie , Richer Chantal , Healy Jasmine , Chen Shu-Huang , Droit Arnaud , Sinnett Daniel , Pastinen Tomi
Published: March 2023

PDF - 192K, IPA networks generated by genes identified to be differentially methylated in samples carrying the t(12;21) translocation
Supplementary Figure 3 from Microtubule-Associated Histone Deacetylase 6 Supports the Calcium Store Sensor STIM1 in Mediating Malignant Cell Behaviors
Authors: Chen Ying-Ting , Chen Yih-Fung , Chiu Wen-Tai , Liu Kuan-Yu , Liu Yu-Lin , Chang Jang-Yang , Chang Hsien-Chang , Shen Meng-Ru
Published: March 2023

PDF file - 652K, Entinostat or sodium butyrate does not affect SOCE activation and STIM1 trafficking.
Supplementary Figure Legends from Integration of High-Resolution Methylome and Transcriptome Analyses to Dissect Epigenomic Changes in Childhood Acute Lymphoblastic Leukemia
Authors: Busche Stephan , Ge Bing , Vidal Ramon , Spinella Jean-François , Saillour Virginie , Richer Chantal , Healy Jasmine , Chen Shu-Huang , Droit Arnaud , Sinnett Daniel , Pastinen Tomi
Published: March 2023

PDF - 30K, Legend for Supplementary Figures S1-S5
Supplementary Methods from Tumor MMP-1 Activates Endothelial PAR1 to Facilitate Vascular Intravasation and Metastatic Dissemination
Authors: Juncker-Jensen Anna , Deryugina Elena I. , Rimann Ivo , Zajac Ewa , Kupriyanova Tatyana A. , Engelholm Lars H. , Quigley James P.
Published: March 2023

PDF file - 137K, Additional experimental procedures are described including RT-qPCR, MMP-1 silencing, cell proliferation and adhesion assays, endothelial permeability and transendothelial migration, chick embryo intravasation and spontaneous/experimental metastasis model and immunohistochemistry.
Supplementary Figure Legend from Tumor MMP-1 Activates Endothelial PAR1 to Facilitate Vascular Intravasation and Metastatic Dissemination
Authors: Juncker-Jensen Anna , Deryugina Elena I. , Rimann Ivo , Zajac Ewa , Kupriyanova Tatyana A. , Engelholm Lars H. , Quigley James P.
Published: March 2023

PDF file - 93K
Supplementary Figure Legend from miRNA-95 Mediates Radioresistance in Tumors by Targeting the Sphingolipid Phosphatase SGPP1
Authors: Huang Xiaoyong , Taeb Samira , Jahangiri Sahar , Emmenegger Urban , Tran Elisa , Bruce Jeff , Mesci Aruz , Korpela Elina , Vesprini Danny , Wong C. Shun , Bristow Robert G. , Liu Fei-Fei , Liu Stanley K.
Published: March 2023

PDF file - 54K
Supplementary Figure 5 from miRNA-95 Mediates Radioresistance in Tumors by Targeting the Sphingolipid Phosphatase SGPP1
Authors: Huang Xiaoyong , Taeb Samira , Jahangiri Sahar , Emmenegger Urban , Tran Elisa , Bruce Jeff , Mesci Aruz , Korpela Elina , Vesprini Danny , Wong C. Shun , Bristow Robert G. , Liu Fei-Fei , Liu Stanley K.
Published: March 2023

PDF file - 5606K, Clonogenic survival of PC3 and DU145 cells treated with FTY-720.
Supplementary Figure 4 from miRNA-95 Mediates Radioresistance in Tumors by Targeting the Sphingolipid Phosphatase SGPP1
Authors: Huang Xiaoyong , Taeb Samira , Jahangiri Sahar , Emmenegger Urban , Tran Elisa , Bruce Jeff , Mesci Aruz , Korpela Elina , Vesprini Danny , Wong C. Shun , Bristow Robert G. , Liu Fei-Fei , Liu Stanley K.
Published: March 2023

PDF file - 3917K, SGPP1 levels in PC3 cells transfected with SGPP1 siRNA.
Supplementary Table 5 from G-CSF Receptor Positive Neuroblastoma Subpopulations Are Enriched in Chemotherapy-Resistant or Relapsed Tumors and Are Highly Tumorigenic
Authors: Hsu Danielle M. , Agarwal Saurabh , Benham Ashley , Coarfa Cristian , Trahan Denae N. , Chen Zaowen , Stowers Paris N. , Courtney Amy N. , Lakoma Anna , Barbieri Eveline , Metelitsa Leonid S. , Gunaratne Preethi , Kim Eugene S. , Shohet Jason M.
Published: March 2023

PDF file - 90K, Ingenuity curated microRNA target genes. Gene target components of KEGG pathways as determined with Ingenuity miRPATH microRNA Target Filter analysis of experimentally validated microRNA-mRNA target interactions.
Supplementary Table 4 from G-CSF Receptor Positive Neuroblastoma Subpopulations Are Enriched in Chemotherapy-Resistant or Relapsed Tumors and Are Highly Tumorigenic
Authors: Hsu Danielle M. , Agarwal Saurabh , Benham Ashley , Coarfa Cristian , Trahan Denae N. , Chen Zaowen , Stowers Paris N. , Courtney Amy N. , Lakoma Anna , Barbieri Eveline , Metelitsa Leonid S. , Gunaratne Preethi , Kim Eugene S. , Shohet Jason M.
Published: March 2023

PDF file - 57K, 25 microRNAs upregulated in CD114+ cells from 3 neuroblastoma cell lines (IMR-32, LA-N-5, NGP) for gene pathway prediction using two independent software tools.
Supplementary Table S3 from Alkaline Phosphatase ALPPL-2 Is a Novel Pancreatic Carcinoma-Associated Protein
Authors: Dua Pooja , Kang Hye Suk , Hong Seung-Mo , Tsao Ming-Sound , Kim Soyoun , Lee Dong-ki
Published: March 2023

Supplementary Table S3 PDF file - 544K, Table S3. Sequence of RT-qPCR primers, siRNA and aptamers used in the study
Supplementary Materials and Methods from Alkaline Phosphatase ALPPL-2 Is a Novel Pancreatic Carcinoma-Associated Protein
Authors: Dua Pooja , Kang Hye Suk , Hong Seung-Mo , Tsao Ming-Sound , Kim Soyoun , Lee Dong-ki
Published: March 2023

Supplementary Materials and Methods PDF file - 106K, Supplementary Material and Methods
Supplementary Figure S2 from Alkaline Phosphatase ALPPL-2 Is a Novel Pancreatic Carcinoma-Associated Protein
Authors: Dua Pooja , Kang Hye Suk , Hong Seung-Mo , Tsao Ming-Sound , Kim Soyoun , Lee Dong-ki
Published: March 2023

Supplementary Figure S2 PDF file - 352K, Figure S2. ALPP also act as a target of SQ2
Supplementary Figure S1 from Alkaline Phosphatase ALPPL-2 Is a Novel Pancreatic Carcinoma-Associated Protein
Authors: Dua Pooja , Kang Hye Suk , Hong Seung-Mo , Tsao Ming-Sound , Kim Soyoun , Lee Dong-ki
Published: March 2023

Supplementary Figure S1 PDF file - 1466K, Figure S1. The aptamer SQ2 target is a membrane protein.
Supplementary Figure 6 from Novel Small-Molecule Inhibitors of Bcl-XL to Treat Lung Cancer
Authors: Park Dongkyoo , Magis Andrew T. , Li Rui , Owonikoko Taofeek K. , Sica Gabriel L. , Sun Shi-Yong , Ramalingam Suresh S. , Khuri Fadlo R. , Curran Walter J. , Deng Xingming
Published: March 2023

PDF file, 198K, Analysis of toxicity for combination of BXI-72 and IR in vivo.
Supplementary Table 1 from Chk1 Targeting Reactivates PP2A Tumor Suppressor Activity in Cancer Cells
Authors: Khanna Anchit , Kauko Otto , Böckelman Camilla , Laine Anni , Schreck Ilona , Partanen Johanna I. , Szwajda Agnieszka , Bormann Stefanie , Bilgen Turker , Helenius Merja , Pokharel Yuba R. , Pimanda John , Russel Mike R. , Haglund Caj , Cole Kristina A. , Klefström Juha , Aittokallio Tero , Weiss Carsten , Ristimäki Ari , Visakorpi Tapio , Westermarck Jukka
Published: March 2023

PDF file - 66K, Supplementary Table S1. Co-relation between Chk1 and c-MYC nuclear staining in gastric cancer.
Supplementary Figure 4 from Novel Small-Molecule Inhibitors of Bcl-XL to Treat Lung Cancer
Authors: Park Dongkyoo , Magis Andrew T. , Li Rui , Owonikoko Taofeek K. , Sica Gabriel L. , Sun Shi-Yong , Ramalingam Suresh S. , Khuri Fadlo R. , Curran Walter J. , Deng Xingming
Published: March 2023

PDF file, 118K, BXI-61 potently represses lung cancer growth in vivo.
Supplementary Figure 5 from Chk1 Targeting Reactivates PP2A Tumor Suppressor Activity in Cancer Cells
Authors: Khanna Anchit , Kauko Otto , Böckelman Camilla , Laine Anni , Schreck Ilona , Partanen Johanna I. , Szwajda Agnieszka , Bormann Stefanie , Bilgen Turker , Helenius Merja , Pokharel Yuba R. , Pimanda John , Russel Mike R. , Haglund Caj , Cole Kristina A. , Klefström Juha , Aittokallio Tero , Weiss Carsten , Ristimäki Ari , Visakorpi Tapio , Westermarck Jukka
Published: March 2023

PDF file - 213K, Figure S5. Regulation of MYC and cell cycle by Chk1-CIP2A pathway and effect of DNA-PK on CIP2A and pS345-Chk1 levels independent of ATM/ATR.
Supplementary Figure 1 from Novel Small-Molecule Inhibitors of Bcl-XL to Treat Lung Cancer
Authors: Park Dongkyoo , Magis Andrew T. , Li Rui , Owonikoko Taofeek K. , Sica Gabriel L. , Sun Shi-Yong , Ramalingam Suresh S. , Khuri Fadlo R. , Curran Walter J. , Deng Xingming
Published: March 2023

PDF file, 69K, BXIs represent relatively selective cytotoxicity against lung cancer cells (A549 and H1299) compared to normal human bronchial epithelial cells (BEAS-2B).
Supplementary Figure 3 from Chk1 Targeting Reactivates PP2A Tumor Suppressor Activity in Cancer Cells
Authors: Khanna Anchit , Kauko Otto , Böckelman Camilla , Laine Anni , Schreck Ilona , Partanen Johanna I. , Szwajda Agnieszka , Bormann Stefanie , Bilgen Turker , Helenius Merja , Pokharel Yuba R. , Pimanda John , Russel Mike R. , Haglund Caj , Cole Kristina A. , Klefström Juha , Aittokallio Tero , Weiss Carsten , Ristimäki Ari , Visakorpi Tapio , Westermarck Jukka
Published: March 2023

PDF file - 123K, Figure S3. Effect of cell cycle on CIP2A expression.
Supplementary Figure 1 from Chk1 Targeting Reactivates PP2A Tumor Suppressor Activity in Cancer Cells
Authors: Khanna Anchit , Kauko Otto , Böckelman Camilla , Laine Anni , Schreck Ilona , Partanen Johanna I. , Szwajda Agnieszka , Bormann Stefanie , Bilgen Turker , Helenius Merja , Pokharel Yuba R. , Pimanda John , Russel Mike R. , Haglund Caj , Cole Kristina A. , Klefström Juha , Aittokallio Tero , Weiss Carsten , Ristimäki Ari , Visakorpi Tapio , Westermarck Jukka
Published: March 2023

PDF file - 82K, Figure S1. Expression analysis of Chk1 and CIP2A in human malignancies.
Supplementary Figure 7 from Nm23-H1 Binds to Gelsolin and Inactivates Its Actin-Severing Capacity to Promote Tumor Cell Motility and Metastasis
Authors: Marino Natascia , Marshall Jean-Claude , Collins Joshua W. , Zhou Ming , Qian Yongzhen , Veenstra Timothy , Steeg Patricia S.
Published: March 2023

PDF file, 109K, Gelsolin and Nm23-H1 overexpression in 4T1 and MDA-MB-231T cells is not associated with apoptosis.
Supplementary Figure 4 from Nm23-H1 Binds to Gelsolin and Inactivates Its Actin-Severing Capacity to Promote Tumor Cell Motility and Metastasis
Authors: Marino Natascia , Marshall Jean-Claude , Collins Joshua W. , Zhou Ming , Qian Yongzhen , Veenstra Timothy , Steeg Patricia S.
Published: March 2023

PDF file, 92K, A cloned GFP tag on Gelsolin protein does not affect Gelsolin interaction with Nm23-H1 in 4T1 and MDA-MB-231T cells.
Supplementary Methods from YEATS4 Is a Novel Oncogene Amplified in Non–Small Cell Lung Cancer That Regulates the p53 Pathway
Authors: Pikor Larissa A. , Lockwood William W. , Thu Kelsie L. , Vucic Emily A. , Chari Raj , Gazdar Adi F. , Lam Stephen , Lam Wan L.
Published: March 2023

PDF file - 114K
Supplementary Figure 3 from YEATS4 Is a Novel Oncogene Amplified in Non–Small Cell Lung Cancer That Regulates the p53 Pathway
Authors: Pikor Larissa A. , Lockwood William W. , Thu Kelsie L. , Vucic Emily A. , Chari Raj , Gazdar Adi F. , Lam Stephen , Lam Wan L.
Published: March 2023

PDF file - 194K, Gene networks associated with YEATS4 knockdown.
Supplementary Figure 1 from Nm23-H1 Binds to Gelsolin and Inactivates Its Actin-Severing Capacity to Promote Tumor Cell Motility and Metastasis
Authors: Marino Natascia , Marshall Jean-Claude , Collins Joshua W. , Zhou Ming , Qian Yongzhen , Veenstra Timothy , Steeg Patricia S.
Published: March 2023

PDF file, 180K, Latrunculin B treatment distrupts F-actin cytoskeleton structure.
Supplementary Figure 1 from YEATS4 Is a Novel Oncogene Amplified in Non–Small Cell Lung Cancer That Regulates the p53 Pathway
Authors: Pikor Larissa A. , Lockwood William W. , Thu Kelsie L. , Vucic Emily A. , Chari Raj , Gazdar Adi F. , Lam Stephen , Lam Wan L.
Published: March 2023

PDF file - 53K, YEATS4 is frequently amplified and overexpressed in NSCLC and does not display subtype specificity.
Supplementary Figure 2 from Loss of miR-204 Expression Enhances Glioma Migration and Stem Cell-like Phenotype
Authors: Ying Zhe , Li Yun , Wu Jueheng , Zhu Xun , Yang Yi , Tian Han , Li Wei , Hu Bo , Cheng Shi-Yuan , Li Mengfeng
Published: March 2023

PDF file - 160K, Immunohistochemical staining of SOX4 and EphB2 in xenograft tumor.
Supplementary Figure 8 from Mutationally Activated PIK3CAH1047R Cooperates with BRAFV600E to Promote Lung Cancer Progression
Authors: Trejo Christy L. , Green Shon , Marsh Victoria , Collisson Eric A. , Iezza Gioia , Phillips Wayne A. , McMahon Martin
Published: March 2023

PDF file, 107K, Quantification of Western Blots.
Supplementary Tables 1 - 5 from Bispecific Antibody to ErbB2 Overcomes Trastuzumab Resistance through Comprehensive Blockade of ErbB2 Heterodimerization
Authors: Li Bohua , Meng Yanchun , Zheng Lei , Zhang Xunmin , Tong Qing , Tan Wenlong , Hu Shi , Li Hui , Chen Yang , Song Jinjing , Zhang Ge , Zhao Lei , Zhang Dapeng , Hou Sheng , Qian Weizhu , Guo Yajun
Published: March 2023

PDF file - 150K, Relative binding affinity of anti-ErbB2 antibodies for the trastuzumab epitope on ErbB2 in BT-474 cells (S1); Relative binding affinity of anti-ErbB2 antibodies for the pertuzumab epitope on ErbB2 in BT-474 cells (S2); Binding affinities of recombinant anti-ErbB2 antibodies for ErbB2-ECD (S3); Pharmacokinetic parameters of recombinant anti-ErbB2 antibodies in mice (S4); ErbB receptor expression on breast cancer cell lines (S5).
Supplementary Figure 5 from Mutationally Activated PIK3CAH1047R Cooperates with BRAFV600E to Promote Lung Cancer Progression
Authors: Trejo Christy L. , Green Shon , Marsh Victoria , Collisson Eric A. , Iezza Gioia , Phillips Wayne A. , McMahon Martin
Published: March 2023

PDF file, 1804K, PIK3CAH1047R promotes rapid development of adenocarcinoma.
Supplementary Figure 3 from Mutationally Activated PIK3CAH1047R Cooperates with BRAFV600E to Promote Lung Cancer Progression
Authors: Trejo Christy L. , Green Shon , Marsh Victoria , Collisson Eric A. , Iezza Gioia , Phillips Wayne A. , McMahon Martin
Published: March 2023

PDF file, 638K, Pathology grading system used to determine progression of lung tumors.
Supplementary Figure 6 from CIP2A Modulates Cell-Cycle Progression in Human Cancer Cells by Regulating the Stability and Activity of Plk1
Authors: Kim Jae-Sung , Kim Eun Ju , Oh Jeong Su , Park In-Chul , Hwang Sang-Gu
Published: March 2023

PDF file, 120K, CIP2A depletion causes Plk1 mislocalization during mitosis.
Supplementary Figure 5 from CIP2A Modulates Cell-Cycle Progression in Human Cancer Cells by Regulating the Stability and Activity of Plk1
Authors: Kim Jae-Sung , Kim Eun Ju , Oh Jeong Su , Park In-Chul , Hwang Sang-Gu
Published: March 2023

PDF file, 162K, CIP2A depletion reduces sensitivity to BI2536.
Supplementary Figure Legend from Trastuzumab-Resistant Cells Rely on a HER2-PI3K-FoxO-Survivin Axis and Are Sensitive to PI3K Inhibitors
Authors: Chakrabarty Anindita , Bhola Neil E. , Sutton Cammie , Ghosh Ritwik , Kuba María Gabriela , Dave Bhuvanesh , Chang Jenny C. , Arteaga Carlos L.
Published: March 2023

PDF file - 74K