bluuebunny/crossref_metadata_2025 huggingface dataset:
Applicability Analysis of Pre-Stack Inversion in Carbonate Karst Reservoir
Authors: Wang Rui , Liu Bo
Published: August 2022

Although pre-stack inversion has been carried out on reservoir prediction, few studies have focused on the application of pre-stack for seismic inversion in fractured-cavity carbonate reservoirs. In carbonate rock, complicated combinations and fluid predictions in karst caves are remain unclear. Post-stack methods are commonly used to predict the position, size, and fillings of caves, but pre-stack inversion is seldom applied in carbonate karst reservoirs. This paper proposes a pre-stack inversion method for forward modeling data and oil survey seismic data, using both points to indicate the application of pre-stack inversion in karst caves. Considering influence of cave size, depth, and filler on prediction, three sets of models (different caves volume; different fillings velocity of caves; complicated combination of caves) are employed and inverted by pre-stack inversion. We analyze the pre-stack results to depict Ordovician oil bearing and characterize caves. Geological model parameters came from actual data of the Tahe oilfield, and seismic data were synthesized from geological models based on full-wave equation forward simulation. Moreover, a case study of pre-stack inversion from the Tahe area was employed. The study shows that, from both the forward modeling and the oil seismic data points of view, pre-stack inversion is applicable to carbonate karst reservoirs.
Energy and Exergy Analysis of Solar Organic Rankine Cycle Coupled with Vapor Compression Refrigeration Cycle
Authors: Kim Man-Hoe
Published: August 2022

This study investigates a combined power generation and cooling system comprising an organic Rankine cycle (ORC) and a vapor compression cycle (VCC). Thermodynamic analyses of the system were conducted for two operation modes, i.e., the basic ORC mode and the ORC–VCC mode, using six different working fluids: R245fa, R114, R600, R142b, R152a, and R1234yf. The results showed that the thermal efficiency of the combined ORC–VCC system was almost twice that of the basic ORC system. The effects of thermodynamic parameters, such as the turbine inlet temperature and pressure and the condensing temperature, on the system performance were discussed. The second-law efficiency, cooling capacity, and coefficient of performance were addressed by varying the condensing temperature.
Mineral-Supported Photocatalysts: A Review of Materials, Mechanisms and Environmental Applications
Authors: Li Xue , Simon Ulla , Bekheet Maged F. , Gurlo Aleksander
Published: August 2022

Although they are of significant importance for environmental applications, the industrialization of photocatalytic techniques still faces many difficulties, and the most urgent concern is cost control. Natural minerals possess abundant chemical inertia and cost-efficiency, which is suitable for hybridizing with various effective photocatalysts. The use of natural minerals in photocatalytic systems can not only significantly decrease the pure photocatalyst dosage but can also produce a favorable synergistic effect between photocatalyst and mineral substrate. This review article discusses the current progress regarding the use of various mineral classes in photocatalytic applications. Owing to their unique structures, large surface area, and negatively charged surface, silicate minerals could enhance the adsorption capacity, reduce particle aggregation, and promote photogenerated electron-hole pair separation for hybrid photocatalysts. Moreover, controlling the morphology and structure properties of these materials could have a great influence on their light-harvesting ability and photocatalytic activity. Composed of silica and alumina or magnesia, some silicate minerals possess unique orderly organized porous or layered structures, which are proper templates to modify the photocatalyst framework. The non-silicate minerals (referred to carbonate and carbon-based minerals, sulfate, and sulfide minerals and other special minerals) can function not only as catalyst supports but also as photocatalysts after special modification due to their unique chemical formula and impurities. The dye-sensitized minerals, as another natural mineral application in photocatalysis, are proved to be superior photocatalysts for hydrogen evolution and wastewater treatment. This work aims to provide a complete research overview of the mineral-supported photocatalysts and summarizes the common synergistic effects between different mineral substrates and photocatalysts as well as to inspire more possibilities for natural mineral application in photocatalysis.
Co-Combustion Behavior of Paper Sludge Hydrochar and Pulverized Coal: Low Rank Coal and Its Product by Hydrothermal Carbonization
Authors: Su Buxin , Wang Guangwei , Li Renguo , Xu Kun , Wu Junyi , Li Desheng , Liu Jiawen
Published: August 2022

In this paper, the combustion behavior of low rank coal and its product after hydrothermal carbonization with paper sludge hydrochar were studied. The Raman technique was used to compare the structural differences between raw coal and the product. Thermogravimetric analysis was employed to conduct experiments of single sample and their mixtures with different proportions at a heating rate of 20 °C/min, the activation energy of chemical reactions was calculated. The results showed that upgraded product had higher carbon ordering degree than raw coal and the ignition temperature and burnout temperature of the product were advanced. Compared with raw coal, the combustion characteristic parameters C and S of the product were higher, indicating that its combustibility was better. As for the mixture, when the paper sludge hydrochar ratio was not more than 10%, the mixed fuel combustion curve was still similar to coal curve. After the paper sludge hydrochar ratio exceeded 10%, the activation energy of the mixed combustion reaction of paper sludge hydrochar and upgraded coal was lower than that of raw coal and paper sludge hydrochar. These results indicated that the mixture of upgraded coal and paper sludge hydrochar as mixed fuel was a better option.
Effect of In-Situ Stress on Hydraulic Fracturing of Tight Sandstone Based on Discrete Element Method
Authors: Wang Hongjian , Gong Wanlin , Yuan Guangxiang , Wang Xiaodong , Zhao Jitao , Su Yujie , Wang Yuchen
Published: August 2022

The tight sandstone reservoir in the Qianfoya formation of well PL-3 of the Puguang gas field in Sichuan, China, obtained a high-yield gas flow after a volume fracturing treatment. However, the stimulated reservoir volume (SRV), fracture morphology, scale and formation law still remain unclear. Based on particle flow discrete-element theory in this paper, we carried out a few trials of the Brazilian splitting test, uniaxial compression and triaxial compression of rock mechanics. Meanwhile, the research also testified to the conversion relationship between macroparameters and microparameters, established the numerical simulation on hydraulic fracturing through PFC2D discrete element software, and finally analyzed the influence of difference coefficients on the fracturing effect, in terms of different in-situ stresses. The conclusions are as follows: firstly, the influence of in-situ stress is essential for the direction, shape and quantity of fracture propagation, and the fractures generated by hydraulic fracturing are mainly tension fractures, accounting for over 90% of the total longitudinal fractures. Secondly, it is indicated that when the difference coefficient is small in the in-situ stress, the fractures formed by hydraulic fracturing expand randomly around the wellbore. When the difference coefficient Kh of in-situ stress is above 0.6, the development of hydraulic fractures is mainly controlled by in-situ stress; as a result, the fractures tend to expand in the vertical direction of the minimum horizontal principal stress and the fracture shape is relatively singular. When the difference coefficient of in-situ stress was 0.3, in total, 3121 fractures were generated by fracturing, and the fractal dimension D value of the fracture network complexity was 1.60. In this case, this fracturing effect was the best and it is the easiest to achieve for the purpose of economical and effective development on large-scale volume fracturing.
Skeletal Characteristics of Children and Adolescents with Turner Syndrome
Authors: Kawai Masanobu , Hasegawa Yukihiro
Published: August 2022

Turner syndrome (TS) is a chromosomal disorder characterized by a short stature and gonadal dysgenesis, the latter of which requires estrogen replacement therapy (ERT) to induce and maintain secondary sexual characteristics. Insufficient ERT is associated with compromised skeletal health, including bone fragility, in adults with TS. In particular, estrogen insufficiency during adolescence is critical because the acquisition of a defective bone mass during this period results in impaired bone strength later in the life. In addition to bone mass, bone geometry is also a crucial factor influencing bone strength; therefore, a more detailed understanding of the skeletal characteristics of both bone mass and geometry during childhood and adolescence and their relationships with the estrogen status is needed to prevent compromised skeletal health during adulthood in TS. Although a delay in the initiation of ERT is associated with a lower bone mineral density during adulthood, limited information is currently available on the effects of ERT during adolescence on bone geometry. Herein, we summarize the current knowledge on skeletal characteristics in children and adolescents with TS and their relationships with estrogen sufficiency, and discuss the potential limitations of the current protocol for ERT during adolescence in order to achieve better skeletal health in adulthood.
Oak Decline Caused by Biotic and Abiotic Factors in Central Europe: A Case Study from the Czech Republic
Authors: Macháčová Markéta , Nakládal Oto , Samek Michal , Baťa Daniel , Zumr Václav , Pešková Vítězslava
Published: August 2022

Oak decline presenting symptoms of tracheomycosis have been observed globally over long periods of time. Since the 1990s, oak decline has been considered to be a multifactorial process where abiotic predisposing factors play a significant role. Nevertheless, biotic factors, such as subcortical insects and fungal pathogens, may influence the decline process, as some insect species transmit spores of tracheomycotic pathogens. We investigated biotic agents (subcortical insects, Ophiostoma spp. and Phytophthora spp.) in six declining oak stands located within mesophytic and thermophytic zones in the Czech Republic, where five dry years occurred from 2015 to 2019. The spectrum of insect pests of oak stands was investigated using two methods: reared from logs from each stand and window traps. The presence of Ophiostoma fungi was assessed from cultivated woodblocks; Phytophthora pathogens were isolated from soil samples. In total, 2931 subcortical insect individuals were captured during the 2021 vegetation period. The most species-rich group of the subcortical insect complex involved in oak decline consisted of the families Cerambycidae: Xylotrechus antilope; Curculionidae: Scolytus intricatus, Xyleborus monographus; and Buprestidae: Agrilus biguttatus, A. sulcicollis. The presence of Ophiostoma was detected in all stands with different intensities between tree parts. Several important oak pests were positively correlated with the occurrence of Ophiostoma. On the contrary, from all soil samples, Phytophthora plurivora was found at only one studied oak stand. Based on the results, a new modified model of biotic and abiotic factors involved in the oak decline is proposed.
AFLP-Based Genetic Structure of Lithuanian Populations of Small Balsam (Impatiens parviflora DC.) in Relation to Habitat Characteristics
Authors: Jocienė Lina , Stravinskaitė Kristė , Krokaitė Edvina , Janulionienė Rasa , Rekašius Tomas , Paulauskas Algimantas , Marozas Vitas , Kupčinskienė Eugenija
Published: August 2022

Currently, there is an increasing focus on understanding the interactions between genetic features of the invader and environmental factors that ensure the success of invasion. The objective of our study was to evaluate the genetic diversity of Lithuanian populations of highly invasive small balsam (Impatiens parviflora) by amplified fragment length polymorphism (AFLP) markers and to relate molecular data to biotope features defined by employing neighboring species of herbaceous plants. Low polymorphism of I. parviflora populations was observed at AFLP loci. Hierarchical analysis of molecular variance did not reveal differentiation of populations depending on biotope, geography, or road types. Bayesian analyses of AFLP data demonstrated many genetic clusters. Our results suggest multiple introductions of I. parviflora into Lithuania. The polymorphism of AFLP loci of populations significantly correlated with the total coverage by herbaceous plants in the sites. Defined by principal component analysis, the variability of study sites was most related to the coverage of herbaceous plants and least related to the molecular features of I. parviflora populations. The sites with I. parviflora were classified into agricultural scrubland, riparian forest, and urban forest biotopes. Of them, urban forest was distinguished by the highest coverage of I. parviflora and the lowest Ellenberg indicatory values for light, soil acidity, and richness in nutrients.
Analysis of Temperature Field in the Dielectrophoresis-Based Microfluidic Cell Separation Device
Authors: Tada Shigeru , Seki Yoshinori
Published: August 2022

Cell separation techniques based on dielectrophoresis are of high interest as an effective method of performing cell separation non-invasively on cells. However, dielectrophoresis devices have the problem that cells in the device are exposed to a high-temperature environment due to the generation of Joule heat caused by high-voltage application and dielectric-loss heat when the applied voltage is AC voltage. There is concern that the heat generated in the device may affect cell viability, cell cycle and apoptosis induction. In this study, the temperature field inside the dielectrophoretic cell separation device was experimentally and numerically investigated. The temperature rise at the bottom of the flow channel in the device was measured using the LIF method, and the thermofluidal behavior of the device was numerically simulated by adopting a heat generation model that takes the Joule and dielectric-loss heating into account in the energy equation. The temperature rise in the device was evaluated and the effect of the heat generation on cells in the device is discussed.
Development of Bread Dough by Sheeting: Effects of Sheeting Regime, Bran Level and Bran Particle Size
Authors: Albasir Mohamed Otman Saleh , Alyassin Mohammad , Campbell Grant Murray
Published: August 2022

The effects of sheeting on bread dough development and baked loaf quality were investigated, using Dynamic Dough Density and springback to quantify development, and examining effects of the sheeting regime on bread quality in terms of loaf volume and crumb structure. Bread doughs, with and without bran at different levels and particle sizes, were formed through a short mixing period, then sheeted through a benchtop manual sheeter at roll gaps of 6, 9 and 12 mm for different numbers of sheeting passes. The sheeting of doughs without bran increased dough expansion and baked loaf volume up to 12 sheeting passes. Loaves were larger after sheeting at a 6 mm roll gap, reflecting the greater gluten development at the smaller gap, although the crumb structure was less fine, with fewer gas cells and larger average gas cell diameters. The addition of bran decreased dough expansion and loaf volumes, with Fine bran and Coarse bran both more damaging than Medium bran, indicating the opportunity to optimise bran particle size to maximise bread quality. Sheeting was effective in alleviating the damaging effects of bran, with sheeting for 8 passes giving more dough expansion, larger loaf volumes and finer crumb structures than sheeting for 12 passes, indicating an even more damaging effect of bran when gluten is overstretched by sheeting. The work demonstrates the opportunity to enhance bread quality, particularly of healthy high-fibre breads, by employing sheeting to enhance gluten development and to offset the damage to gluten caused by the presence of bran.
Frontiers of Bio-Decolonization: Indigenous Data Sovereignty as a Possible Model for Community-Based Participatory Genomic Health Research for Racialized Peoples in Postgenomic Canada
Authors: Valiani Arafaat Amin
Published: August 2022

This paper explores the manners in which Indigenous and allied non-Indigenous researchers, medical directors, and knowledge-keepers (among others) extend the ethical precepts and social justice commitments that are inherent in community-based participatory research (CBPR) approaches to genomics. By means of a genealogical analysis of bioethical discourses, I examine the problem in which genomic science claims to offer potentially beneficial genetic screening tools to Indigenous and racialized peoples who have and continue to struggle with historical health inequity, exploitation, and exclusion by the very biomedical institutions which would be charged with the task of ethically introducing these biomedical tools. This investigation focuses on Indigenous data sovereignty (IDS) as an approach established by Indigenous communities and scientists to gain access to the benefits of genomic health which, if the field’s promises are true, aims to counter the historical neglect or exploitation by biomedical researchers and institutions. I chart the role of CBPR principals as it pertains to collective efforts by both Indigenous communities and non-Indigenous allies to create the social, biomedical, and institutional conditions to improve Indigenous health equity in the context of genomic science in two specific studies: the Silent Genome initiative (British Columbia) and the Aotearoa Variome (Aotearoa/New Zealand). This investigation contributes insights to social science literatures in health equity for racialized communities, biomedical ethics, Indigenous Science and Technology Studies, and decolonial biomedical and technoscience histories.
Prognostic Impact of TP53 Mutations and Tumor Mutational Load in Colorectal Cancer
Authors: Ho Vincent , Chung Liping , Lim Stephanie H. , Ma Yafeng , Wang Bin , Lea Vivienne , Abubakar Askar , Ng Weng , Lee Mark , Roberts Tara L. , Chua Wei , Lee C. Soon
Published: August 2022

The DNA damage response (DDR) is critical for maintaining genome stability, and abnormal DDR—resulting from mutations in DNA damage-sensing and repair proteins—is a hallmark of cancer. Here, we aimed to investigate the predictive power of DDR gene mutations and the tumor mutational load (TML) for survival outcomes in a cohort of 22 rectal cancer patients who received pre-operative neoadjuvant therapy. Univariate analysis revealed that TML-high and TP53 mutations were significantly associated with worse overall survival (OS) with TML-high retaining significance in multivariate analyses. Kaplan–Meier survival analyses further showed TML-high was associated with worse disease-free (p = 0.036) and OS (p = 0.024) results in our patient cohort. A total of 53 somatic mutations were identified in 22 samples with eight (36%) containing mutations in DDR genes, including ATM, ATR, CHEK2, MRE11A, RAD50, NBN, ERCC2 and TP53. TP53 was the most frequently mutated gene, and TP53 mutations were significantly associated with worse OS (p = 0.023) in Kaplan–Meier survival analyses. Thus, our data indicate that TML and TP53 mutations have prognostic value for rectal cancer patients and may be important independent biomarkers for patient management. This suggests that prognostic determination for rectal cancer patients receiving pre-operative neoadjuvant therapy should include consideration of the initial TML and tumor genetic status.
The Xtabay: From Forest Guardian to Hungry Demon
Authors: Osborn Marijane
Published: August 2022

The Xtabay is a legendary Mayan forest entity associated with the sacred ceiba tree. The prose-poem by native ethnologist Antonio Mediz Bolio, translated here, represents the version of her story that he knew a century ago, where she appears as a temptress who lures young men under the tree to become her slaves. Behind the romantic sensibility that pervades this poem may lurk the combined shadow of two avatars, an ancient goddess of the hunt and a hybrid bird-woman who regards as prey those who threaten her forest or the creatures that call it their home.
What Aspects of Religion and Spirituality Affect the Physical Health of Cancer Patients? A Systematic Review
Authors: Almaraz David , Saiz Jesús , Moreno Martín Florentino , Sánchez-Iglesias Iván , Molina Antonio J. , Goldsby Tamara L.
Published: August 2022

In recent years, the literature on the relationship between religion and spirituality (R/S) and the health of cancer patients has been flourishing. Although most studies focus on mental health, many study the physical health of these individuals. In order to summarize the findings of these studies, we reviewed the most recent research on this subject using the PubMed and PsycInfo databases. The objective of this systematic review was to recognize the primary R/S variables studied in research on physical health in cancer contexts. We found that spiritual well-being was the most-researched variable in studies of these characteristics, followed by R/S struggles and other variables such as religious coping; religious commitment or practice; or self-rated R/S. In general, R/S seems to have a positive association with the physical health of cancer patients, although the results are quite heterogeneous, and occasionally there are no relationships or the association is negative. Our results may assist in improving interventions that include spirituality in clinical settings as well as the development of holistic approaches, which may have a positive impact on the quality of life and well-being of cancer patients.
Community Pharmacists’ Perceptions of Their Role in Provision of Anemia Management in Jazan Region, Saudi Arabia, and the Associated Barriers
Authors: Madkhali Osama A. , Alzahrani Fahad
Published: August 2022

Background: As a result of the lack of research exploring community pharmacists’ perspectives on anemia care, this study examined the perceived practices and barriers to anemia management services in Saudi Arabia. Methods: A questionnaire was administered to community pharmacists to validate pharmacist perceptions of their role in anemia care. Using an 11-item role test, pharmacists were asked about their perceptions of anemia management. Pharmacy anemia management barriers were explored using 20 items, and their perceptions of inter-professional contact were examined by two items. Data analyses were performed using SPSS version 22. Results: This research involved 324 community pharmacists, 62.3% of whom were males. There were significant differences between the location of pharmacy education and the perceived practice of anemia management. The most common barriers to anemia counseling were patients’ lack of knowledge about anemia, health beliefs, patients’ perceptions that their doctor takes care of them, and time constraints. The majority of respondents said they would like to have more contact with other healthcare professionals regarding the care of anemia patients. Conclusions: A positive perception of pharmacists’ role in anemia management is prevalent among Saudi pharmacists in the Jazan region. Anemia management is challenging due to time limitations and patient-related problems.
Polysaccharide Paint Binding Media at Two Pharaonic Settlements in Nubia
Authors: Fulcher Kate , Spencer Neal , Budka Julia , Stacey Rebecca J.
Published: August 2022

Paints and plasters from two pharaonic settlement sites in Nubia (northern Sudan) were analysed to investigate the presence and origin of organic binding materials. The town of Sai was founded around the time of the pharaonic conquest of Kush (Upper Nubia) around 1500 BC, with Amara West created as a new centre for the pharaonic administration of the region around 1300 BC. Recent fieldwork at both sites yielded examples of paint palettes, including several from houses. These provide a different economic and social context to funerary contexts upon which most previous research has been conducted, making this study the first to report on binding media for vernacular architecture in the Nile Valley. It is also the first study of binding media from Nubia. Gas chromatography mass spectrometry (GC-MS) analysis of methanolysed and silylated paint and plaster samples revealed a range of monosaccharides present in eight of the seventeen samples from Amara West, and in six of the seven samples from Sai. Interpretation of the data was supported by field collection and study of locally available botanical gums. The results indicate that mixtures of gums were in use as a pigment binder at both sites during the mid- to late-second millennium BC. The possibility that some of these plant gums could have been imported from the Mediterranean is also posited.
Thermography Investigation and Seismic Vulnerability Assessment of a Historical Vaulted Masonry Building
Authors: Cascardi Alessio , Longo Fabio , Perrone Daniele , Lassandro Paola , Aiello Maria Antonietta
Published: August 2022

Typically, historical masonry constructions were only designed due to gravity loads. The structural detailing, aimed at improving the seismic performance, was introduced thanks to the advancement in performance-based seismic design approaches in recent decades. In this context, the vaults play a key role. Depending on the construction technology, material, shape and constraints, the vault can modify the load patterns both in static and/or dynamic conditions. Furthermore, in heritage buildings, the possible presence of frescos or decorations increase the difficulties in assessing the technological nature of the vault. Non-destructive in situ investigation techniques, such as thermography, can be a powerful tool to improve the level of knowledge with respect to structural detailing and increase the prediction capability of the numerical model. The present paper discusses the results of a large thermography campaign performed in a cultural masonry building located in the south of Italy. The extensive investigation was aimed at identifying the typologies of vaults covered by worth frescos. This peculiarity was considered in the structural analysis in order to investigate the influence of the vault typology, in terms of plan stiffness versus the global seismic vulnerability. The outcomes demonstrated that thermography was decisive in improving the level of knowledge and obtaining a more reliable prediction of the seismic response.
Domesticities and the Sciences
Authors: Opitz Donald
Published: August 2022

The ubiquity and yet distinctiveness of domestic sites for scientific research have attracted an unprecedented focus in recent years, especially in studies concerned with the gendering of science and the rise of citizen science movements of the late twentieth century. It is fair to say this “new” subfield has now entered a stage of maturity, even as it continues to grow and adopt new theoretical perspectives. Following an historiographical shift we might call the “domestic turn” in histories of science, “domesticities” emerges as a critical, analytical lens through which to view scientific developments in a range of historical contexts globally. The emphasis in the literature has moved from one on the “house of experiment” to one on the “laboratory of domesticity”, attending particularly to the permeability, plasticity, portability, and plurality of instances of entanglement between domesticities and science. In view of the emergence of new empirical cases and theoretical perspectives, this paper revisits the status of domesticities within histories of science to consider the current status of the historiography and to suggest even further directions for new research.
Promising Antioxidant and Insecticidal Properties of Chemically Characterized Hydroethanol Extract from Withania adpressa Coss. ex Batt
Authors: Salamatullah Ahmad Mohammad
Published: August 2022

Withania adpressa Coss. ex Batt is a wild plant belonging to the family Solanaceae, native to the Mediterranean area. The present work was undertaken to study the chemical composition, antioxidant and insecticidal properties of Withania adpressa Coss. ex Batt (W. adpressa) extract. The plant extract was obtained by use of maceration with hydroethanol, and its chemical composition was characterized by use of HPLC. Evaluation of antioxidant potency was achieved by use of DPPH, TAC and FRAP bioassays. Insecticidal activity was tested against Callosobruchus maculatus (C. maculatus) by investigating its mortality, longevity, fecundity and emergence after being immersed with hydroethanol extract of W. adpressa. HPLC analysis revealed that the studied extract is rich in apigenin, luteolin, rutin hydrate, gallic acid, p-coumaric acid, acid gallate, and ferulic acid. The crude extract of W. adpressa recorded excellent antioxidant potencies with calculated values as follows: IC-50 of 49.01 ± 0.65 µg/mL (DPPH), EC50 of 119.61 ± 1.81 µg/mL (FRAP), and 483.47 ± 5.19 µg EAA/mg (TAC). Regarding insecticidal activity, it was revealed that the mortality of C. maculatus after being treated with hydroethanol extract reached 94.21 ± 2.05%. In addition, hydroethanol extract effectively controlled the longevity, fecundity, and the emergence of C. maculatus. The outcome of the present work suggests that W. adpressa derivatives have promising antioxidant and insecticidal properties, and consequently, they may be used as natural insecticides and antioxidants.
Disability and Participation in Breast and Cervical Cancer Screening: A Systematic Review and Meta-Analysis
Authors: Andiwijaya Fahrin Ramadan , Davey Calum , Bessame Khaoula , Ndong Abdourahmane , Kuper Hannah
Published: August 2022

It is well established that access to preventative care, such as breast or cervical cancer screening, can reduce morbidity and mortality. Certain groups may be missed out of these healthcare services, such as women with disabilities, as they face many access barriers due to underlying inequalities and negative attitudes. However, the data have not been reviewed on whether women with disabilities face inequalities in the uptake of these services. A systematic review and meta-analysis were conducted to compare the uptake of breast and cervical cancer screening in women with and without disabilities. A search was conducted in July 2021 across four databases: PubMed, MEDLINE, Global Health, and CINAHL. Quantitative studies comparing the uptake of breast or cervical cancer screening between women with and without disabilities were eligible. Twenty-nine studies were included, all from high-income settings. One third of the 29 studies (34.5%, n = 10) were deemed to have a high risk of bias, and the remainder a low risk of bias. The pooled estimates showed that women with disabilities have 0.78 (95% CI: 0.72–0.84) lower odds of attending breast cancer screening and have 0.63 (95% CI: 0.45–0.88) lower odds of attending cervical cancer screening, compared to women without disabilities. In conclusion, women with disabilities face disparities in receipt of preventative cancer care. There is consequently an urgent need to evaluate and improve the inclusivity of cancer screening programs and thereby prevent avoidable morbidity and mortality.
Measuring the Economic Value of the Negative Externality of Livestock Malodor in South Korea
Authors: Han Kwideok , Vitale Jeffrey , Lee Yong-Geon , Ji Inbae
Published: August 2022

The South Korean livestock industry has increased in scale and production, generating positive impacts on the national economy. However, livestock externalities, primarily malodor, have subsequently led to increased conflicts between producers and affected communities. This study estimated Korean households’ willingness-to-pay (WTP) for government subsidies to help address livestock malodor using a contingent valuation method (CVM) derived from a double-bounded dichotomous choice model. The annual average household WTP was estimated at 29,206 Korean won (KRW) (USD 25). This was slightly higher than the respondents’ self-reported average amount of KRW 25,457 (USD 22). The estimated economic value nationally is KRW 628 billion (USD 546 million) annually, for a total of KRW 3.14 trillion (USD 2.73 billion) over a proposed five-year period. The public’s estimated WTP can be leveraged to improve livestock management practices, more efficient waste disposal techniques, and improved husbandry methods to address conflicts between producers and surrounding communities.
Household Groups’ Land Use Decisions Investigation Based on Perspective of Livelihood Heterogeneity in Sichuan Province, China
Authors: Tang Hong , Liu Jian , Dai Xiaowen , Zhang Yun , He Wendai , Yin Qi , Huang Feng , Ran Ruiping , Liu Yunqiang
Published: August 2022

Land use decision-making is a vital livelihood strategy associated with the rational collocation of livelihood asset endowments by rural households. Based on the perspective of livelihood heterogeneity, this paper collected the data from 540 farm households in 27 villages in three Sichuan Province counties to identify the land use decision-making characteristics of the household groups. A land use decision-making framework (LUDF) based on the sustainable livelihood framework (SLF) was established and dynamic and dual indicators were developed to divide the sample into six household groups. The household livelihood capital, livelihood strategies, and livelihood diversity were then analyzed at the regional and household group level, and the land use decisions of these household groups were explored, from which the following was found. (1) Overall livelihood capital in the study area was low, and except for human assets, there were few other assets, with households in the survey areas being more inclined to engage in non-farming livelihood activities; however, households in Nanjiang and Qionglai had greater livelihood activities choices than Luxian. (2) The LL-type household was the chief household group; the household group distribution in Qionglai was well-proportioned but uneven in Nanjiang and Luxian; and the HL-type, ML-type, and LL-type household livelihood strategy choices were polarized. (3) Most households were involved in land self-cultivation, followed by land transfer-in, land transfer-out, and land abandonment households. Specifically, there were more households that cultivated fragmented landholdings than specialized households with large-scale landholdings, the land transfer rate was relatively low, the transfer-in land area was far greater than the transfer-out land areas, and a small number of households that had abandoned their land were still involved in agricultural production. (4) There were obvious discordant human–land relationships and inefficient land uses in the study area. Based on these findings, relevant policy recommendations are given to improve farm household livelihood capital, optimize livelihood strategies, and assist in land use decision-making.
The COVID-19 Pandemic and Ophthalmic Care: A Qualitative Study of Patients with Neovascular Age-Related Macular Degeneration (nAMD)
Authors: O’Connor Seán , Treanor Charlene , Ward Elizabeth , Wickens Robin , O’Connell Abby , Culliford Lucy , Rogers Chris , Gidman Eleanor , Peto Tunde , Knox Paul , Burton Benjamin , Lotery Andrew , Sivaprasad Sobha , Reeves Barnaby , Hogg Ruth , Donnelly Michael ,   MONARCH Study Group
Published: August 2022

Concerns have been expressed about the relationship between reduced levels of health care utilisation and the COVID-19 pandemic. This study aimed to elicit and explore the views of patients with neovascular age-related macular degeneration (nAMD) regarding the COVID-19 pandemic and their ophthalmic care. Semi-structured telephone interviews were conducted with thirty-five patients with nAMD taking part in a larger diagnostic accuracy study of home-monitoring tests. Participants were recruited using maximum variation sampling to capture a range of key characteristics including age, gender and time since initial treatment. Transcribed interview data were analysed using a deductive and inductive thematic approach. Three themes emerged from the analysis: i. access to eye clinic care. ii. COVID-19-mitigating factors and care delivery and iii. social and personal circumstances. Participants reported anxieties about cancelled or delayed appointments, limited communication from clinic-based services about appointments, and the impact of this on their ongoing care. Despite these concerns, there was apprehension about attending appointments due to infection risk and a perception that nAMD patients are a ‘high risk’ group. Views of those who attended clinics during the study period were, however, positive, with social distancing and infection control measures providing reassurance. These findings contribute to our understanding about experiences of patients with nAMD during the COVID-19 pandemic and may have potential implications for future planning of care services in similar circumstances. Innovative approaches may be required to address issues related to access to care, including concerns about delayed or cancelled appointments.
Resource-Strengthening Training for Parents of Adolescents with Problematic Gaming (Res@t-P): A Clinical Pilot Study
Authors: Hülquist Joel , Fangerau Nicole , Thomasius Rainer , Paschke Kerstin
Published: August 2022

Background: Problematic gaming (PG) has become an increasing mental health issue among adolescents during the preceding years. The role of parents and the family environment in the development of PG has been repeatedly emphasized. However, the structured involvement of parents in the therapy is still largely insufficient. Resource-strengthening training for parents of adolescents with PG (Res@t-P) is a new parent-centered 8-week group intervention to fill this substantial gap. The present pilot study aimed to collect first information on its potential effectiveness in improving parental and family factors. Methods: The study was conducted in a clinical setting with N = 43 parents of adolescents with PG, applying a pre- and post-follow-up design. Standardized questionnaires on psychological stress perception, family communication, family functioning, media rules, and adolescent PG symptoms were applied at three measurement points (before, at the end of, and 6 weeks after the training). Conditional growth models were estimated. Results: Over time, an improvement in parental and family aspects as well as a reduction in adolescent PG symptoms could be observed. Conclusions: The results of the present pilot study on the effectiveness of Res@t-P are promising. No causal inferences can be drawn at this stage. A randomized-controlled intervention study is highly warranted.
Lead in Air, Soil, and Blood: Pb Poisoning in a Changing World
Authors: Mielke Howard W. , Gonzales Christopher R. , Powell Eric T. , Egendorf Sara Perl
Published: August 2022

(1) Background: Leaded petrol became a worldwide vehicle fuel during the 20th century. While leaded petrol was totally banned on 30 August 2021, its lead (Pb) dust legacy remains in the environment as soil Pb. The health impacts of Pb are well known and risks occur when exposures are above zero. The inextricable links between air Pb, soil Pb, and blood Pb are not widely A. Exposure risks continue even after banning leaded petrol and must be explored. (2) Methods: This article evaluates selected examples of temporal measurements of atmospheric Pb and human Pb exposure and the effect of soil Pb on blood Pb. Several search engines were used to find articles on temporal changes in air Pb and human Pb exposures. New Orleans studies provided empirical data on the association between soil Pb and blood Pb. (3) Results: Vehicle Pb emission trends are closely associated with air Pb and blood Pb. Air Pb deposited in soil becomes a reservoir of Pb dust that is known to be remobilized into the atmosphere. (4) Conclusions: The dust from leaded petrol continues to pose major exposure risks to humans. Exogenous sources of Pb in soil and its remobilization into air along with endogenous bone Pb establish the baseline exposure of children and adults. Reducing human exposure to Pb requires novel policies to decrease exogenous contact from the reservoir of Pb in soil and curtailing remobilization of soil Pb into the atmosphere. Mitigating exposure to soil Pb must therefore play a central role in advancing primary prevention.
Parental Efficacy in Managing Smartphone Use of Adolescents with Attention-Deficit/Hyperactivity Disorder: Parental and Adolescent Related Factors
Authors: Chou Wen-Jiun , Hsiao Ray C. , Yen Cheng-Fang
Published: August 2022

Parental management has an important role in preventing problematic smartphone use among adolescents with attention-deficit/hyperactivity disorder (ADHD). This study aimed to examine the parental factors (e.g., demographics, depressive symptoms and parenting styles) and adolescent factors (e.g., demographics, ADHD and oppositional defiant disorder [ODD] symptoms, and problematic smartphone use) related to parental efficacy in managing adolescent smartphone use (PEMASU) among 237 parents of adolescents with ADHD. PEMASU was measured by the Parental Smartphone Use Management Scale. Parental depressive symptoms and parenting styles (parental affection/care and overprotection) were measured by the Center for Epidemiologic Studies—Depression Scale and Parental Bonding Instrument, respectively. Adolescent ADHD and ODD symptoms and problematic smartphone use were measured by the Swanson, Nolan, and Pelham, version IV scale and Problematic Smartphone Use Questionnaire, respectively. Three models of hierarchical linear regression were performed to examine the parental and adolescent factors related to PEMASU. The results indicated that adolescent older age and more severe ODD symptoms and problematic smartphone use were significantly associated with lower PEMASU, whereas greater parental affection/care was significantly associated with higher PEMASU. This study demonstrated that both parental and adolescent factors contribute to PEMASU among parents of adolescents with ADHD. Intervention programs aiming to enhancing PEMASU need to take these related factors into consideration.
What Drives Elderly People in China Away from COVID-19 Information?
Authors: Gao Xudong , Ding Feng , Ai Ting
Published: August 2022

Background: A worrying phenomenon has emerged in recent years: a growing number of people have stopped seeking coronavirus disease 2019 (COVID-19) information and have started deliberately avoiding it. Even though the virulence of COVID-19 has now weakened, the proportion of severe illnesses and deaths in elderly people is still much higher than in other age groups. However, no study has focused on this topic. This is the first study to explore the level of COVID-19 information avoidance among elderly people, and to identify the barriers and potential factors associated therewith. Methods: Convenience sampling was used to recruit 907 elderly people in Wuhan, China. Data collection measures included a sociodemographic questionnaire, health information avoidance scale, information overload scale, general self-efficacy scale, and health anxiety inventory. Results: A total of 72.3% of elderly participants reported COVID-19 information avoidance. Regarding COVID-19-related information reading habits, 44.5% of the elderly only read the title, 16.0% merely skimmed through the content, and 22.9% skipped all relevant information. The most common reasons for this result were information overload (67.5%), underestimation of the infection risk (58.1%), and uselessness of information (56.4%). The main factors associated with COVID-19 information avoidance were recorded as information overload, age, health anxiety, and children (p < 0.05). Conclusions: China should strengthen its health communication regarding COVID-19 in accordance with the characteristics of elderly people, adopt more attractive publicity methods on traditional media, improve censorship about health information, and pay more attention to the childless elderly and the elderly aged 80 and above.
The Lived Experiences of Women without COVID-19 in Breastfeeding Their Infants during the Pandemic: A Descriptive Phenomenological Study
Authors: Yip Ka-Huen , Yip Yuk-Chiu , Tsui Wai-King
Published: August 2022

The coronavirus disease 2019 (COVID-19) outbreak in 2020 has led to several changes and disturbances in the daily lives of the general public. Particularly for new (first-time) mothers, there has been a significant impact on the practices of raising and feeding their babies. Social distancing measures everywhere have made mothers hesitant to breastfeed their babies anywhere else but at home. Combined with the fear of being infected with COVID-19, the present situation has created unprecedented barriers for breastfeeding mothers to accessing various types of support: emotional, instrumental, informational, and appraisal. There has been no research on the influence of the pandemic on social support regarding breastfeeding in Hong Kong. This study aimed to explore the social support and impact of COVID-19 on mothers breastfeeding their babies. Semi-structured interviews were conducted with 20 currently breastfeeding women in Hong Kong. Colaizzi’s seven-step method was used for data analysis. Two key themes emerged from the interview data: (1) positive influences on breastfeeding support during COVID-19 and (2) negative influences on breastfeeding support during COVID-19. Our findings may help mothers prepare to breastfeed their babies in places other than their homes.
Predicting the Prognostic Value of POLI Expression in Different Cancers via a Machine Learning Approach
Authors: Xu Xuan , Jaberi-Douraki Majid , Wallace Nicholas A.
Published: August 2022

Translesion synthesis (TLS) is a cell signaling pathway that facilitates the tolerance of replication stress. Increased TLS activity, the particularly elevated expression of TLS polymerases, has been linked to resistance to cancer chemotherapeutics and significantly altered patient outcomes. Building upon current knowledge, we found that the expression of one of these TLS polymerases (POLI) is associated with significant differences in cervical and pancreatic cancer survival. These data led us to hypothesize that POLI expression is associated with cancer survival more broadly. However, when cancers were grouped cancer type, POLI expression did not have a significant prognostic value. We presented a binary cancer random forest classifier using 396 genes that influence the prognostic characteristics of POLI in cervical and pancreatic cancer selected via graphical least absolute shrinkage and selection operator. The classifier was then used to cluster patients with bladder, breast, colorectal, head and neck, liver, lung, ovary, melanoma, stomach, and uterus cancer when high POLI expression was associated with worsened survival (Group I) or with improved survival (Group II). This approach allowed us to identify cancers where POLI expression is a significant prognostic factor for survival (p = 0.028 in Group I and p = 0.0059 in Group II). Multiple independent validation approaches, including the gene ontology enrichment analysis and visualization tool and network visualization support the classification scheme. The functions of the selected genes involving mitochondrial translational elongation, Wnt signaling pathway, and tumor necrosis factor-mediated signaling pathway support their association with TLS and replication stress. Our multidisciplinary approach provides a novel way of identifying tumors where increased TLS polymerase expression is associated with significant differences in cancer survival.