bluuebunny/crossref_metadata_2025 huggingface dataset:
Remedies of Online Gendered Violence against Women in the Digital Context
Authors: Zhong Jingqi
Published: October 2024

Online gendered violence (OGV) is a range of harmful behaviors committed through the use of technology as a means of enforcing gender norms that result in mainly sexual and psychological harm or suffering to women. Based on psychological studies, OGV can be classified into four distinct categories: digital sexual harassment, appearance-based violence, gender role-based violence, and anti-feminism violence. The impact of OGV on women is amplified by the systemic discrimination they face in society, making their experiences of online violence unique and especially harmful. This paper explores the legal recognition of OGV, the mechanisms for holding perpetrators accountable, and the potential relief paths available to victims. Through a detailed analysis of these issues, this study aims to provide a comprehensive understanding of how the legal system can be enhanced to more effectively respond to OGV. It argues that a multifaceted approach—one that includes legal reforms, algorithmic transparency, and stronger social support systems—is essential in mitigating the effects of OGV and ensuring justice for women in digital spaces.
The process of the diffusion of Sichuan cuisine
Authors: Huang Zhouye
Published: October 2024

The paper analyzes the process of the diffusion of Sichuan cuisine, such as what kind of marketing strategy does this type of cuisine use to be succeed. After doing a review for several papers, the paper conclude that the process of becoming popular for Sichuan cuisine shows an example of a connection between culture and population that leads to diffusion. The special history, geographical features, marketing strategies and so on all play a big role in presenting the best side of this cuisine to the whole China, even the entire world. It turns out that the cuisine has been successfully spreaded which proves that people from other regions are willing to accept this culture. Thus, in order to let a culture becomes popular, building a close bond that attracts people is significantly crucial.
Feasibility and Exception--The Grand Narrative Theory in the Myths of Buddhist Sculpture Art
Authors: Yao Zhiyuan
Published: October 2024

This paper explores the grand narrative, especially in the context of Buddhist sculpture art. It portrays grand narratives as broad, non-falsifiable systems stemming from a collective story, often focusing on universality and macro theories. The paper also highlights the link between grand narratives and myth. The author examines how grand narrative theory applies to Buddhist art, evident in visual forms like Buddha statues, which function as both religious symbols and narrative components. This article mainly consists of two lines of analysis. One line examines the representation of grandeur and narrative in Buddhist sculptures, while the other line examines the changes in the grand narrative of Buddhist sculptures. The former involves the relationship between images and texts, while the latter involves the feasibility of the end of grand narrative as proposed by Jean-François Lyotard’s theory of grand narrative.
Analysis of Corporate Innovation and Development Strategies Based on the SWOT Model - Taking Nintendo as an Example
Authors: Bao Renzhi
Published: October 2024

Under the impact of the COVID-19 pandemic, people’s outdoor activities have been banned due to the quarantine policy, and indoor entertainment activities have become the mainstream method for people to pass the time. During this period, the video game industry had achieved tremendous achievements. By analyzing the representative companies, it is helpful for managers or investors to recognize the future development direction of the market after the pandemic. This article uses the SWOT analysis method to analyze Nintendo, one of the leader in the game console industry, to evaluate and summarize its performance during and after the pandemic. Through research, it is found that although Nintendo has made many profits by relying on its advantages during the pandemic. It has also exposed its shortcomings in market forecasting and risk management. The pandemic has provided Nintendo with new development directions in mobile games and digital sports but also brought threats such as the decline in the purchasing power of target consumers. Based on the above analysis, relevant suggestions are provided to Nintendo, such as increasing fan encouragement for mod developers and increasing investment in the above two new development directions.
An Analysis of Chinese Narrative Poems from the Perspective of the Narrator, the Case Study of Han Yuefu Poems
Authors: Shi Xinyue
Published: October 2024

This paper explores the narrative techniques in Han Dynasty Yuefu poetry, with particular attention to how the narrator’s perspective enhances both storytelling and emotional depth. Through the analysis of selected poems, it highlights how shifts between omniscient and limited perspectives enrich character portrayal and convey complex emotions. By placing Yuefu poetry within the broader tradition of Chinese literature, the study challenges the common perception that classical Chinese poetry is purely lyrical, suggesting instead that narrative elements play a crucial role. It argues for a re-evaluation of these poems, emphasising the interplay between narration and emotion, and how this contributes to the development of Chinese narrative art. Additionally, the paper considers how Yuefu poetry, with its distinct narrative strategies, laid important groundwork for later developments in Chinese literary traditions. This study underscores the importance of looking at ancient Chinese poetry from a narrative perspective, recognising its contribution to the evolution of storytelling in Chinese literature.
Real Estate Market Transformations Amidst Post-Pandemic Sino-U.S. Economic Trends
Authors: Xing Xinyu
Published: October 2024

In the post-pandemic era, the global economic landscape has undergone profound changes. As the world’s largest economies, the economic policies and market performances of the United States and China have exerted far-reaching impacts on the global real estate market. This paper delves into the current state and future trajectory of the real estate market under Sino-U.S. economic trends, focusing on commercial real estate, residential investment, property taxes, financing, and laws and regulations. It also incorporates keywords such as easements, deed transfers, premium discount rates, home mortgages, police powers, liens, common law, fixtures, joint leases, marital property, private property, and trespassing to provide a comprehensive analysis.
Current Status of Semaglutide Injection andDevelopment Prospects in China
Authors: Wen Jianqiao
Published: October 2024

Obesity is a global issue that closely affects public health, and China’s obesity rate is among the highest in the world. Recently, Semaglutide injection was approved for marketing in China as the first weekly formulation for long-term weight control. This review consolidates and analyzes various types of research related to Semaglutide regarding weight loss, to comprehensively describe the different aspects of the drug. As a glucagon-like peptide 1 receptor agonists (GLP-1RA), Semaglutide works by mimicking the action of innate hormone to enhance the cell signaling activity and corresponding outcome. It has been approved to effectively reduce weight and improve weight-related factors in overweight or obese patients with a guaranteed safety profile. Comparing to traditional methods of losing weight, this medication is time and effort-saving, which makes it highly competitive in this field. Although there are still unsolved issues and challenges faced by the drug, such as high price and acceptance among doctors and patients, it is highly likely to become a new and anticipated method of weight management in China
Research progress of plant α-linolenic acid
Authors: Bai Yuxin
Published: October 2024

α-Linolenic acid is a polyunsaturated fatty acid characterized by three double bonds and is recognized as one of the essential fatty acids for human health. It serves multiple critical functions, including nutritional supplementation, enhancement of brain development, and protection of nerve cells. In recent years, researchers globally have investigated natural plant sources abundant in α-linolenic acid and developed more efficient extraction methods, thereby significantly advancing the study of this fatty acid. This paper reviews the physiological effects and sources of plant-derived α-linolenic acid, summarizes the biosynthetic pathways, and outlines the primary extraction processes to provide the theoretical evidence for ongoing research and innovation in this field.
Comparative Analysis of Sponge City Drainage System Schemes Based on SWMM
Authors: Wang Yuchen
Published: October 2024

In this paper, the drainage system schemes of sponge city are compared and analyzed based on Storm Water Management Model (SWMM). First, this paper builds a model in SWMM to explore the effect of green roof, rain garden and reservoir on solving the excessive pressure of urban drainage system during rainstorm, and analyzes the results of the model. Through comparative analysis, the best scheme is obtained. The results show that the green roof has the best effect among the three schemes, which can reduce the flow of the pipeline, increase the drainage cycle and thus reduce the pressure of the drainage system. Second, limited by the size of the area, it can only reduce the flow of the drainage system. The reservoir has the worst effect, mainly because the intensity is not large enough, and if it encounters greater rainfall, the reservoir can play a key role in regulating and storing. Through the analysis of the model results, an effective scheme can be obtained to relieve the pressure of urban drainage system in rainstorm, so as to reduce the drainage pipe flow and reduce the risk of urban waterlogging. The purpose of this paper is to provide effective reference for the construction of sponge city, relieve the pressure of drainage system and reduce the hidden danger of urban waterlogging.
Review on the application of ginsenosides and their pharmaceutical preparations in the treatment of breast cancer
Authors: Wang Zicheng
Published: October 2024

Ginsenosides, as the main active ingredients of ginseng, have shown great potential in the treatment of breast cancer. Studies have found that many types of ginsenosides, such as PPD ginsenosides Rh2, Rg3, CK and PPT ginsenosides Rg1, Rg2, have inhibitory effects on breast cancer cells. These components can effectively inhibit the development of breast cancer by directly inhibiting the proliferation of cancer cells, inducing apoptosis, enhancing the anticancer ability of NK cells, and remodeling the tumor microenvironment. In addition, the liposome and nanoparticle drug delivery system synthesized by ginsenoside showed great advantages in the application of drug formulations, providing a new strategy for the targeted transportation of antitumor drugs and improving the tumor killing ability. These research results not only provide a new strategy for breast cancer treatment, but also expand the application prospect of ginsenosides in cancer treatment. In the future, with the in-depth research, ginsenosides and their pharmaceutical preparations are expected to play a greater role in the treatment of breast cancer and bring more hope to patients.
Implementation and Efficacy of EVENODD Coding in High-Reliability Data Storage Architectures
Authors: Zeng Yujie
Published: October 2024

This paper provides a comprehensive examination of EVENODD encoding and its crucial role in enhancing data recovery processes, particularly under various failure scenarios. The study initiates with a detailed analysis of the foundational principles of EVENODD coding, emphasizing its unique capability to efficiently recover data in the event of multiple disk failures. By exploring the mechanics behind the generation of redundant data through XOR operations and the creation of parity bits, the paper illustrates how EVENODD encoding achieves robust fault tolerance. The research then conducts a comparative analysis between EVENODD and other established error correction methods, such as extended Hamming codes, Reed-Solomon codes, and cross parity. These methods are evaluated based on their performance in different failure contexts, focusing on their ability to recover data and their computational efficiency. The findings reveal that EVENODD encoding significantly outperforms these alternatives in scenarios involving multiple data disk failures, offering enhanced reliability and effectiveness. This makes EVENODD a highly valuable technique for high-reliability storage systems, where data integrity is paramount. The paper concludes by proposing future research directions aimed at further optimizing the computational complexity of EVENODD encoding. Additionally, it explores the potential for EVENODD’s application in distributed storage systems, where its fault tolerance capabilities could be particularly beneficial in maintaining data integrity across geographically dispersed environments.
Green insurance empowers high-quality development: A Literature Review
Authors: Liu Xinyi
Published: October 2024

Green insurance plays a positive role not only in strengthening environmental risk management, aiding the development of green industries, and facilitating the application of new green technologies, but also in enhancing environmental and ecological protection. It can continuously raise public and societal awareness of green and environmental protection, guide the allocation of social resources, and support the green and low-carbon development of the economy and society. This paper reviews the literature on whether and how green insurance can empower high-quality development. The paper organizes domestic and international practices related to green insurance, summarizes the characteristics of three main international models and other typical developments of green insurance in China. It also focuses on the preliminary formation of the green insurance system in Huzhou City, Zhejiang Province, the combination of government and effective market, and the development status of multiple types of insurance. It summarizes the challenges faced, such as the imperfect professional service system and insufficient innovation, and finally proposes policy recommendations for the further development of green insurance, including the establishment and improvement of institutional systems and industry standards, and the effective enhancement of the marketization of insurance products.
Evolving Woman in Film
Authors: Xia Ziyu (Fiona)
Published: October 2024

Throughout the time, the film industry has always mirrored the troubling issues in the society. Especially on the evolving societal norms and the uprising feminist movements. This paper examines the change in female portrayal and social critique on both Swept Away (1975) and Promising Young Woman (2021). Both films closely examine the patriarchal constraints in an contrasting directions, creating a trend from submissible to resistance. Lina Wertmüller’s Swept Away (1975) resides in the conservative 1970s, which criticizes how the social constraints enforce the submissiveness of woman. On the other hand, Emerald Fennell’s Promising Young Woman (2021) is more current and empower woman in their ability to reject patriarchal pressure in their own advocation for justice. Through the comparative analysis, the paper highlights the transition from passive to active portrayals of woman in film and examines the evolving societal conflicts that shape and hinger woman empowerment at different times.
Risk and path analysis of global industrial transformation in the context of climate change
Authors: Gao Rui
Published: October 2024

Global industrial transformation is accelerating, and climate risks and natural disasters brought by climate change may have an impact on global industrial transformation. Therefore, how to promote global industrial reform in the context of climate change is an important issue that needs to be urgently solved by various countries at this stage. Starting from the background of climate change, this paper deeply discusses the impact of climate change on global industrial transformation and analyzes the possible risks and challenges. The results show that the impact of climate change on global industrial transformation may be a double-edged sword. Global industrial development may make new progress under the influence of climate change, but climate change may affect the process of industrial transformation, bring some pressure to industrial development, and reduce the economic benefits of industrial development. Therefore, it is necessary to scientifically understand the impact of climate change, take effective measures to mitigate climate risks and promote high-quality industrial development. Due to the differences in the economic levels of different countries, it is necessary to formulate corresponding development measures according to their conditions in the process of coping with climate change. The conclusions of this paper provide implications for coping with climate change and global industrial transformation.
Research on the influence of venture capital on enterprise innovation
Authors: Wu Yuxuan
Published: October 2024

In recent years, against the backdrop of increasingly fierce market competition and continuous technological development, venture capital has had a very important role in influences enterprise innovation. Firstly, this study defines the concept and characteristics of venture capital; Secondly, it explains the function of venture capital in enterprise financing, enterprise merger and acquisition, and enterprise innovation. Then, it analyzes the influence of venture capital on enterprise innovation as well as illustrates it with examples. The results show that venture capital has a significant positive impact on enterprise innovation and promotes high-quality economic development. This study aims to discuss the influence of venture capital on enterprise innovation through case analysis and provide a reference for enterprises and investors.
Examining the Effects of Status Quo Bias on Household/Individual Carbon Consumption
Authors: Pan Samuel
Published: October 2024

The research investigated the degree of influence status quo bias has on rising carbon emissions. It found that status quo bias strongly regulates the actions of households and individuals when making environmental decisions. Through transportation, individuals lack the incentive to switch to eco- friendly methods and display inertia to their original path. Consumption habits and market interactions also show individuals’ reluctance to new technologies. Results show that the status quo bias plays a significant role as one of the fundamental causes of uncontrollable carbon emissions.
Vital Protein:The Structure and Function of Protein
Authors: Zhang Hancheng
Published: October 2024

Protein engineering has shown significant growth in recent years, resulting in the development of various advanced goods generated from proteins, including biosensors, antibiotics, vaccines, and genetic scissors.These products are developed by extensive analysis of protein structure and function.The exceptional benefits of protein diversity have been highly regarded for its exciting technological prospects.If the mystery of protein can be revealed definitely as the precision of protein structure contains countless development potential,the protein’s autonomous repair ability and strong replication ability can be used for biological and pharmaceutical engineering.This essay,by collecting the research literature and published essays on the structure and function of proteins,it explores the polypeptides folding,the structure of amino acids--the monocase of protein,the function determined by the structure of protein ,the transition metal in the protein and biosensor with diagnostics.
A Comparative Study on Fault-Tolerant Coding Techniques in RAID6 Analyzing the Efficiency and Limitation of EVENODD and RDP Codes
Authors: Qu Chenhan
Published: October 2024

With the development of computer science, the application of information storage in various fields such as business, military, gaming, and more has been playing a important role in our day-to-day life. This paper provides a systematic analysis of the current academic literature on data storage, offering an overview of RAID storage technology. It discusses the historical development of RAID technology, including real-world application examples, and highlights some researchers’ innovative upgrades to the technology. The paper elucidates the details and applications of the EVENODD and RDP algorithms, which are closely related to RAID technology, and analyzes the error correction performance of these two algorithms in scenarios where only a single device fails, supported by relevant calculations. The analysis concludes that the RDP algorithm has an advantage in recovering from single device failures when comparing EVENODD and RDP. Finally, the future prospects and some new application scenarios of RAID data storage technology are discussed.
A Model that Explains the Contrasting SST Trends in the Southern Pacific Ocean
Authors: Wang Jialu , Deng Kaihuai
Published: October 2024

Sea surface temperature (SST) of the southern Paciﬁc Ocean plays an important role in ocean-atmospheric interactions, influencing both regional and global climate and ecosystems. The contrasting SST trends in the southern Paciﬁc Ocean during 1993-2021 are noted by analyzing satellite and in-situ datasets, consisting of SST warming trend (0.05℃·yr−1) in the region of 80°W-180,30°S-50°S and cooling trend (−0.04℃·yr−1) in the area of 60°W-150°W, 55°S-70°S. A detailed trend analysis for the wind and sea ice concentration suggest that Ekman transport and sea ice radiative positive feedback are the two key contributors to the contrasting SST trends. The intensiﬁed downwelling (upwelling), induced by the Ekman transport and strengthened westerlies, gives rise to warm (cold) water swarming in (upturning) from lower latitudes (deeper ocean), which causes SST warming (cooling). Moreover, the sea ice increase at higher latitudes, due to both the cold water transport from deeper ocean layers and broken ice transport from polar regions, strengthens the cooling trend through sea ice positive radiative feedback. In conclusion, these ﬁndings underscore the complexity of SST trends in the southern Paciﬁc Ocean, highlighting the critical roles of Ekman transport and sea ice radiative feedback in shaping regional climate dynamics.Plain Language Summary: The southern Paciﬁc Ocean is an indispensable part in the climate system while it still remained poorly observed. The SST trend is regarded as a critical indicator of global climate change. Using the satellite and in-situ datasets, we find that the contrasting SST trends from 1993 to 2021, one area in this region is warmed by 0.3℃ per decade, while another area is cooled by -0.1℃ per decade. Considering impacts of various factors such as wind, sea ice and radiation, the primarily explanation is that wind-driven warm (cold) water from the subtropics (deeper ocean) ﬂows in and goes downward (goes upward and ﬂow away) in the warm (cold) area through oceanic circulation and leads to the SST warming (cooling). Additionally, the cooling trend is also related to the cold water that flows to higher latitudes and forms ice there and at the same time, trash ice from polar regions driven by enhanced south wind speed will be transported there. As a result, ice increases, reﬂects more shortwave radiation to space, and surface downward shortwave radiation decreases which contributes to SST decreases.
Exploring the Link between the Obesity and ADHD
Authors: Huang Bei
Published: October 2024

Obesity is a chronic, multifactorial and recurrent disease. ADHD is a chronic neurodevelopmental disorder in early childhood. The core symptoms include attention deficit, hyperactivity/impulsivity and oppositional defiance. Research shows that there is a significant correlation between obesity and ADHD, and the probability of overweight and obese children suffering from ADHD is significantly higher than that of normal weight children. This paper discusses the association mechanism between ADHD and obesity from the perspectives of genetics, eating disorders, intestinal flora and poor physical exercise. At the same time, in view of the prevention and intervention of the comorbidity of ADHD and obesity, this paper also puts forward various means such as diet intervention, exercise prevention intervention and drug treatment. However, the relationship between obesity and ADHD is complex, and the comorbidity problem needs to be solved urgently. Establishing an effective early screening system, implementing targeted prevention and intervention measures, and strengthening public awareness and understanding of comorbidities are important ways to improve the quality of life of this group. Further research is needed in the future.
Whether Social Media Negative Emotion Could Forecast the Risk of Enterprise Finance: Evidence from Baidu Tieba
Authors: Meng Yilei
Published: October 2024

In the context of the current era, as a new form of information dissemination, social media has penetrated into every field of people’s life, and its impact on the financial industry has also attracted more and more scholars’ attention. From the perspective of social media, this paper focuses on the impact and prediction of negative emotions reflected by social media on corporate financial risk. In this paper, Pearson correlation coefficient is used for correlation analysis, and a linear regression model is built to analyze the relationship between negative social media and corporate finance. The results show that enterprises and investors can judge the financial risks of enterprises through the negative emotions of social media, thus reducing the losses of enterprises and investors. The conclusions of this study can improve the risk avoidance ability of enterprises to avoid negative emotions on social media, and provide important reference value for future operations.
Enhancing Environmental Conservation through the Implementation of GMOs
Authors: Deng Jianyu
Published: October 2024

The rapid advancements in genetic engineering have opened new frontiers in agriculture, medicine, and environmental conservation. Among these, the potential of genetically modified organisms (GMOs) in preserving biodiversity and combating environmental challenges has garnered significant attention. This article delves into how GMOs contribute to conservation efforts by bolstering species resilience and curbing biodiversity decline. For instance, the case of ash trees in North America facing the threat of emerald ash borers showcases how genetic modification can aid in rescuing endangered species. The discussion also delves into measures overseeing GMO releases into environments highlighting approaches taken by countries such as the U.S. And China to mitigate risks such as diminished genetic diversity and ecological disturbances. While GMOs offer advantages like lowering greenhouse gas emissions and aiding in toxin breakdown, there are concerns about drawbacks such as displacing species or causing unintended ecological consequences. To address these issues innovative solutions are proposed—like using GMOs that self-terminate after their intended purpose or creating GMOs that establish symbiotic relationships with species.
Design of Integrator and Comparator based on Digital Integrated
Authors: Tong Xuanzhen
Published: October 2024

This article discusses the design method of integrator and comparator based on digital integrated circuits and circuit simulation using multisim is used to prove the functionality and performance of the circuits. By studying the advantages of digital circuits a circuit module has been designed which can realize integrator and comparator. This paper describes in detail the functioning and designing steps of the circuit and shows the results after simulation. The advantages, disadvantages and application cases of the design are analyzed through the simulation results. The simulation results show that it can fulfill the needs of various scenarios well.
The Research Advance in Ethical Issues of AI Application
Authors: He Ziyi
Published: October 2024

The topic of AI has become more and more discussed ever since the release of ChatGPT, as its astonishing intelligence has made humans to challenge the boundary. This vagueness then contributes to the emergence of discussions on the ethics of AI. Aiming to clarify the many current academic discussions on the ethics of artificial intelligence and to recognize different ethical perspectives, this study conducts a literature review of the research and discussions among different scholars on ethical issues in the application of artificial intelligence technologies. It is found that the current relevant discussion extends from a micro perspective emphasizing the individual to a macro perspective emphasizing the human race. Research advances on ethical issues in AI applications can be categorized into three levels: personal, social, and global. Among which, the individual level focuses on the ethical issues in algorithmic logic and user data management. The social level focuses on the social employment and public accountability systems. While the global level discusses intellectual property disputes and the social identity of AI robots. Finally, the author gave an evaluation of the gaps and challenges of studying AI ethics and emphasize the importance of addressing ethical issues in AI development and deployment. The paper aims to serve as information for scholars and policymakers, fostering ethical awareness in the AI research community and helping AI technologies to be developed and used responsibly.
Entertainment-oriented Use of ‘Depression’ on Chinese Social Media and Its Impact on Stigmatization of Depression Groups: A Survey Study
Authors: Chen Hailun , Cheng Yushu , Ma Yiming
Published: October 2024

This study investigates the impact of entertainment-oriented uses of the term ‘depression’ on public attitudes and stigmatization. Utilizing a quantitative method collecting data from an online survey of 110 Chinese internet users, the research explores how exposure to casual or humorous references to depression correlates with attitudes towards individuals who actually suffer from depression. Key findings reveal that engagement with entertainment-related content is prevalent, particularly among younger demographics. The study shows that frequent exposure to such content increases the likelihood of using similar statements in casual contexts and decreases people’s trust in others’ depression claim. It is strongly correlated with more negative attitudes toward individuals with depression. Moreover, people who worry more about the misleading effects of entertainment-related term use show stronger willingness to offer support to depression patients.The results are guide for public education and policy. It highlights the need to take steps to address the harmful effects portrayed by recreational use of depression on social media. Recommendations include improving the education system, setting online support groups, and restricting time spent on social media.
The Dissemination and Expression of Female Thought in Korean Pop Culture
Authors: Sun Yiyao
Published: October 2024

The transmission and expression of women’s ideas in Korean popular culture is a global phenomenon that has attracted a wide audience, including teenagers. The different channels through which these ideas are disseminated, such as music, music videos, and social media platforms, aim to understand the influence of the Korean Wave in shaping gender equality and female empowerment. Using a mixed methodology, including content analysis and comments collections, the study revealed the significant impact of Korean pop culture on young people’s self-identity and values. Examples include the different influences and inspirations that different teenagers receive as a result of this culture and the reaction after watching the music video of a K-pop girls’ group. The study concludes that the representation of women’s ideas in Korean popular culture not only challenges traditional notions of gender but also promotes a more egalitarian perspective of thought, helping teenagers to set up the correct social feminine values, and contributing to the continuous development of women’s autonomy and identity.
A microglia-containing 3D human brain organoid for studying HSV-1-induced Alzheimer’s disease
Authors: Yan Jingyi
Published: October 2024

Alzheimer’s disease (AD), recognized for its profound incapacitation, presents with notable cognitive decline and memory deficits. A growing body of research points to a link between infection with herpes simplex virus type 1 (HSV-1) and the exacerbation of AD. Our study pioneers the use of a cutting-edge, three-dimensional human brain organoid model enriched with microglia, referred to as MC-HBO, to explore the mechanisms by which HSV-1 influences the pathogenesis of AD. Through this model, we examined the regulatory effects of cytokines on amyloid-β (Aβ) deposition, a cardinal pathological manifestation of AD. Our findings demonstrate that the suppression of pro-inflammatory cytokines, including tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6), leads to a significant reduction in Aβ deposition. In contrast, the inhibition of anti-inflammatory cytokines, such as interleukin-10 (IL-10) and interleukin-4 (IL-4), was correlated with an increase in Aβ accumulation. These insights into the role of cytokine signaling pathways suggest a promising therapeutic strategy for potentially decelerating the progression of AD.
Principales signos de riesgo prelector en infantes de cuatro años
Authors: Guanuchi Malla Yonder Antonio , Pino Vela Jenny Alexandra , Ponce Guerra César Eduardo
Published: October 2024

En Ecuador, entre el 5 -10% de niños escolares presentan dificultades del aprendizaje. La lectura y la
escritura son habilidades necesarias para el aprendizaje. Para adquirir la habilidad lectora, es necesario
comprender la relación grafema fonema, para esto se requiere de conciencia fonológica, habilidad que se
ha visto afectada en los niños con dislexia, que es una dificultad de la fluidez y comprensión de la lectura y
escritura que puede diagnosticarse en la edad escolar, sin embargo, existen signos en la edad pre escolar
que nos permiten identificar e intervenir a edades tempranas. Para la metodología, se aplicó el test para
la detección temprana de las dificultades en el aprendizaje de la lectura y escritura, en una población
de 28 niños procedentes de tres centros de desarrollo infantil y dos centros terapéuticos, se obtuvieron
los siguientes resultados, los principales signos evidenciados: identificar palabras iguales o diferentes
al 75%, segmentación de sílabas el 67.8%, actividad identificar el fonema /r/ el 50%. La población riesgo
se identificó al 42.9%, gran porcentaje de niños de riesgo procedentes de centros de desarrollo infantil
con dificultades leves 27.3% y severas 31.8%. dificultades severas 42.9% fue similar en ambos sexos.
Discusión y conclusiones: se evidenció similitud de resultados obtenidos por Cevallos y Piedra (2020) en
los principales signos de riesgo pre lector. Estas coinciden con el perfil de niños disléxicos. Existe un alto
porcentaje de niños de riesgo en nuestro medio. No se encontró diferencias en cuanto al sexo.
Diverticulosis coli
Authors: Mikalonis Martynas , Dalsgaard Peter , Tøttrup Anders
Published: October 2024

The incidence of colon diverticulosis and diverticulitis is increasing. This review summarises the current classification and treatment options. Antibiotic treatment is not indicated for uncomplicated diverticulitis in non-immunosuppressed patients. We discuss whether laparoscopic lavage is the best treatment for every patient with Hinchey III diverticulitis. For selected patients with Hinchey III diverticulitis, segmental resection with primary anastomosis may be the optimal surgical treatment. The indication for elective resection in diverticulitis should respect individual patient-related factors such as comorbidities and the impact on quality of life.
Anaesthesiological management of pre-eclampsia and eclampsia
Authors: Andersson Mette Legaard , Lindelof Kim , Wikkelsø Anne
Published: October 2024

A new national treatment guideline from Danish Society of Anaesthesiology and Intensive Care Medicine (DASAIM) outlines the anaesthetic management of pre-eclampsia and eclampsia. Key principles involve blood pressure control, seizure treatment and prophylaxis, and restricted fluid therapy. Treatment algorithms, flow charts and checklists are provided. Anaesthetic recommendations for vaginal delivery and caesarean section are provided. Close monitoring, especially for patients with severe disease, organ dysfunction, or failure, is crucial, requiring a multidisciplinary approach, as argued in this review.
Mothers and Wives: Representation of Women in Lawrence's Sons and Lovers and Woolf's Mrs. Dalloway
Authors: Akter Saima
Published: October 2024

This article examines the representation of women in D.H. Lawrence's Sons and Lovers and Virginia Woolf's Mrs. Dalloway, two classic modernist novels. Second-wave feminism constitutes the conceptual framework of the paper. The paper argues that despite differences in style and subject matter, both novels critique societal expectations and constraints placed upon women in the early 20th century. Both authors highlight the agency and complexity of women while challenging patriarchal conventions through the representation of female characters. The article argues that these works are still relevant in their depiction of the ongoing struggle for the pursuit of women's liberation and gender equality.
Chemotherapy and Immune System: Strategies to Modulate Immune Responses for Improved Outcomes
Authors:   Department of Zoology, Wildlife and Fisheries, University of Agriculture, Faisalabad, Pakistan, SIDDIQA AYESHA , ANEES NEHA , ZAHARA SYEDA SANIA , MASIH NAKASH ,   Institute of Molecular Biology and Biotechnology, The University of Lahore, Lahore, Pakistan, NADEEM AKASH , BIBI MARRIUM , TARIQ MUHAMMAD , RAHMAN ANEES UR
Published: October 2024

Anti-cancerous medications surround a diverse range of drugs designed to counter the growth and metastasis of cancer cells. Ranging from traditional chemotherapy agents to targeted therapies and immunomodulators, these medications aim to disrupt various aspects of cancer cell biology and enhance the body's natural defenses against different malignancies. Chemotherapy plays a fundamental role in cancer treatment and employs powerful drugs to halt or kill rapidly dividing cells, including cancer cells. While effective in eradicating tumors, chemotherapy can also impact healthy cells, leading to different impairments in the body. This approach is integral in curative and palliative care, often used in combination with other therapies to achieve integrated cancer management. Chemotherapy induces various alterations in the immune system, influencing short-term and long-term responses. While certain agents stimulate immunogenic cell death, releasing signals for immune recognition, others may cause immunosuppression, impairing the body's ability to defend against infections. Different strategies to modulate immune responses have emerged as pivotal components of modern therapeutic approaches. From immunotherapy advancements to personalized interventions targeting the microbiome, these strategies aim to accelerate the body's natural defenses against cancer. Understanding the intricacies of immune modulation is imperative for exploring treatment plans, maximizing therapeutic benefits, and minimizing adverse effects. Therefore, this chapter explores the connection between chemotherapy and the immune system and strategies to modulate immune responses for improved outcomes.
Ethnopharmacological Strategies for Targeting Pain and Inflammation
Authors:   Department of Zoology, Government College University, Faisalabad, Pakistan, FARZEEN IQRA , ZAFAR NIMRAH , SHAHID MOMINA ,   Department of Pharmacy, University of Agriculture, Faisalabad, Pakistan, YASMEEN MUNAZA , NOOR HAREEM , AFSHAN  , ASHRAF ASMA
Published: October 2024

The ethnopharmacological knowledge propagated over generations in Mediterranean areas. Recent interest in medical ethnobotany and the use of herbs and plants in treating different ailments has rejuvenated interest in herbal medicine, especially those transcendent across generations. By the mid-nineteenth century, plants had provided at least 80% of all medications. To prevent pain and inflammation-related ailments, traditional herbal medicines, NSAIDS and plant bioactive use is a widespread practice. Inflammation is characterized by redness, joint discomfort, stiffness, swollen joints, and reduced joint functionality. Pain is a complex and multifaceted ailment for treatment. Pain and inflammation both may be linked by cyclooxygenase enzyme for the synthesis and release of prostaglandins at the inflammatory site. In the present chapter, an attempt was made to unveil treatment approaches adopted for the management of pain and inflammation with anti-inflammatory and anti-analgesic properties as well as integration with modern medicinal practice. By the mid-nineteenth century, plants had provided at least 80% of all medications.
Unveiling the Defensive Role of Flavonoids: A Toxicant Countermeasure
Authors:   Department of Zoology, Wildlife and Fisheries, University of Agriculture, Faisalabad, Pakistan, ANEES NEHA ,   Department of Pathology, University of Agriculture, Faisalabad, Pakistan, GHAFOOR NAILA , SATTAR QURATULANN , SIDDIQA AYESHA , KHATOON AISHA , AKBAR ALI , HAYAT MUHAMMAD FAISAL , EMAN RIMSHA
Published: October 2024

Flavonoids are phytochemical substances found in many plants, fruits, vegetables, and leaves, and have potential uses in medicinal chemistry. They are plant-derived secondary metabolites with notable antioxidant capabilities. They are categorized based on their chemical composition, level of unsaturation, and carbon ring oxidation. Flavonoids are classified into many subgroups including anthoxanthins (flavanone and flavanol), flavanones, flavanonols, flavans, chalchones, anthocyanidins, and iso-flavonoids. Each of these flavonoids is ubiquitously found in nature. Consuming more foods rich in flavonoids offers several health advantages. Due to their beneficial impact on human health, there is a growing endeavor to extract these natural substances from different plants. Since these natural compounds have positive effects on human health, an increasing effort has been made to isolate these compounds from various plants. Flavonoids have several medical advantages such as anticancer, antioxidant, anti-inflammatory, and antiviral activities. They possess neuroprotective and cardio-protective properties. The biological effects are influenced by the specific flavonoid type, its potential mechanism of action, and its bioavailability. These affordable pharmaceutical ingredients exhibit notable biological activity and have been shown beneficial in treating many ailments. Recent research has focused on isolating them, creating analogs, and studying their impact on human health using diverse methods and animal models. An increasing number of flavonoids have been identified, with their discovery continuing to grow steadily. Thus, this chapter has endeavored to describe the protective function of flavonoids and their beneficial actions to enhance our comprehension of their impact on human health.
Reproductive and Developmental Toxicology
Authors:   Department of Zoology, Wildlife and Fisheries, University of Agriculture, Faisalabad, Pakistan, AZMAT RABIA , JAMEEL MARYAM , TAHIR AMARA , JALAL MUHAMMAD MAKHDOOM , IJAZ MUHAMMAD UMAR , KHAN HAMMAD AHMAD , HAYAT MUHAMMAD FAISAL , AKBAR ALI
Published: October 2024

There has been a growing concern in recent years regarding the potential for reproductive and developmental toxicity resulting from the excessive use of drugs. There are several gaps in the present understanding of reproductive and developmental toxicity and few validated assays to assess the effects of drugs on various stages of the reproductive and developmental cycle because this area of toxicology had not received much attention before. This chapter provides a closer look at several types of drugs, with particular emphasis on the reproductive toxicity associated with the anticancer drug doxorubicin, the detrimental impacts of methotrexate on rapidly proliferating reproductive cells, and the growing apprehension regarding the possible damage of the reproductive systems by antidepressants. Furthermore, corticosteroids also have adverse effects on the reproductive and developmental cycles. To mitigate potential hazards, this thorough analysis highlights the need for a nuanced knowledge of drug-induced reproductive and developmental toxicity. It also emphasizes the need of more research and a holistic strategy for drug safety assessment.
Impacts of Climate Variability on Wildlife, Fisheries and Ecosystems
Authors:   Department of Zoology, Wildlife and Fisheries, University of Agriculture, Faisalabad, Pakistan, Naveed Muhammad , Mateen Abdul , Abbas Amna , Zahra Andleeb , Dureshahwar  , Ansir Fareeha , Suleman Iqra , Taimoor Muhammad
Published: October 2024

This book chapter provides a comprehensive examination of the multifaceted impacts of climate change on wildlife, ecosystems, and fisheries. Through an extensive review of scientific literature and case studies, the chapter explores the interconnected web of consequences arising from global climate shifts. Changes in precipitation patterns, habitat disruption, and rising temperatures all have a powerful influence on the distribution and behavior of various species. This contribution elucidates the intricate connection among biodiversity loss and climate change, providing insights into the disruptions of migration patterns, shifts in phenology, and vulnerability of habitats that are vital for specific species to the impacts of extreme weather events. As an essential component of Earth's ecosystems, the oceans are confronted with unique difficulties including acidification and sea level rise. The alterations mentioned have an impact on marine life, specifically coral reefs, and fish species that are commercially significant. The chapter examines the cascading effects on fisheries, exploring the implications for global seafood supply and the livelihoods of communities dependent on fishing. Mitigation and adaptation strategies are crucial components of the discussion, emphasizing the need for coordinated efforts at various levels of governance which highlights the importance of sustainable resource management, habitat restoration, and international initiatives to curb greenhouse gas emissions. By providing a nuanced knowledge of the complex interactions between ecological systems and climate change, this chapter aims to contribute to a holistic approach to address the issues of wildlife, ecosystem, and fisheries due to climate change.