bluuebunny/crossref_metadata_2025 huggingface dataset:
Fire Scars Negatively Affect Hydraulic Conductivity in White Oak (Quercus alba)
Authors: Dee Justin R. , Stambaugh Michael C. , Smith Kevin T. , Dey Daniel C.
Published: September 2019

Fire management is increasingly used to manage forest stand structure and dynamics. Relatively intense fires can injure the tree stem and induce fire scar formation, affecting subsequent tree growth and wood quality. Here, we consider the physiological effects of fire scarring in white oak. Potential hydraulic conductivity, estimated from the mean vessel area and vessel number, was determined for growth rings formed before, during, and after the year of injury. We measured vessel anatomy using the ROXAS image analysis tool on the cross-sections of 14 white oaks of various ages with fire scars originating in different years through the late 19th and early 20th century. We found that the mean vessel area and potential hydraulic conductivity were significantly reduced for the year of and the year immediately following fire injury. After this two-year period, mean vessel area returned to levels present in wood formed prior to the injury. Age when scarred, radius from the pith when scarred, scar height above ground, and percentage of circumference scarred did not explain the degree to which potential hydraulic conductivity was lost in the fire scar year compared to the year prior. Overall, the magnitude of reduction in potential hydraulic conductivity was small but significant. An earlier study on the same cross-sections verified no reductions in radial growth after fire injury. Thus, it is likely that the conductance of older rings is adequate to sustain conductance. Nonetheless, we recommend further investigation, in particular, the ability to predict how tree size, age, position along a slope, and other variables may influence the degree of wounding and possible losses of potential hydraulic conductivity after the fire. Information like this for white oak and other common tree species may help elucidate the physiological impacts fire injuries have on trees existing in forest stands with periodic fire.
Non-Timber Forest Products Collection Affects Education of Children in Forest Proximate Communities in Northeastern Pakistan
Authors: Zubair Muhammad , Jamil Akash , Lukac Martin , Manzoor Syed Amir
Published: September 2019

Non-timber forest products (NTFPs) are crucial in driving the economy of communities living inside or around forests. The scarcity of business and employment opportunities often push the forest proximate communities to tap a range of NTFPs for earning their livelihoods. In many forest-based communities around the world, children are actively involved in NTFPs collection, which is likely to affect the socioeconomic paradigms of these children. We aim to investigate how the NTFP collection venture affects the education of the children involved in the forest proximate communities of Azad Jammu and Kashmir (AJK), Pakistan. A stratified sampling followed by a series of focus group discussions and one-to-one interviews were carried out to collect information on collection behaviour, patterns, income generation, and other socioeconomic variables. We used a binary logistic regression model to explain children’s state of attending schools using a range of socioeconomic variables. The empirical evidence showed that 42% of the NTFP-collecting children were not going to school, and nearly two-thirds were working in unfavourable working environments. The regression model showed that the role and behaviour of contractors, along with factors like household conditions, were important factors in employing children for long working hours. The study has implications for reforming policies regarding the nexus of income generation and education in the forest-based communities.
Temporal Evolution of Carbon Stocks, Fluxes and Carbon Balance in Pedunculate Oak Chronosequence under Close-To-Nature Forest Management
Authors: Ostrogović Sever Maša Zorana , Alberti Giorgio , Delle Vedove Gemini , Marjanović Hrvoje
Published: September 2019

Under current environmental changes, forest management is challenged to foster contrasting benefits from forests, such as continuous wood supply while preserving biomass production, biodiversity conservation, and contribution to climate change mitigation through atmospheric carbon sequestration. Although being found as globally important, estimates of long-term forest C balance are still highly uncertain. In this context, the chronosequence experiments (space-for-time substitution) might fill this gap in even-aged forests, as they represent an approach that enables the assessment of forest net C balance in the long term. In this research, we explored the dynamics of C stocks and fluxes in different forest pools throughout the rotation period (140 years) of a Pedunculate oak (Quercus robur L.) forest in Croatia. For this purpose, we selected a chronosequence that was made up of seven forest stands with different age (5, 13, 38, 53, 68, 108, and 138 years). To address the issues of uncertainty in C balance estimates, we compared net ecosystem carbon balance (NECB) estimated while using two different approaches, which we name pool-change (from C stocks) approach and component-flux (from C fluxes) approach. Overall, the pool-change approach showed higher NECB estimate, with the greatest difference being observed in younger stands (<50 years). Component-flux approach showed significantly higher uncertainty. Throughout the rotation period, managed pedunculate oak stands become a C sink early in their development phase, between the age of 13 and 35 years according to pool-change and component-flux approach, respectively. During the 140 years, oak forest provided 187.2 Mg C ha−1 (604 m3 ha−1) through thinnings and 147.9 Mg C ha−1 (477 m3 ha−1) in the final cut, while preserving, on average, 88.9 Mg C ha−1 in mineral soil down to 40 cm, 18.2 Mg C ha−1 in dead wood, and 6.0 Mg C ha−1 in the forest floor. Soil C stocks in our chronosequence did not show any age-related trend, indicating that current management practice has no negative effect on soil C stocks. Finally, under current close-to-nature forest management, Pedunculate oak forest showed to be sustainable in providing both economic and ecological ecosystem services.
Shelf Life Extension and Improvement of the Nutritional Value of Fish Fillets through Osmotic Treatment Based on the Sustainable Use of Rosa damascena Distillation By-Products
Authors: Giannakourou Maria C. , Tsironi Theofania , Thanou Ioanna , Tsagri Anna Maria , Katsavou Elena , Lougovois Vladimiros , Kyrana Vasiliki , Kasapidis Georgios , Sinanoglou Vassilia J.
Published: September 2019

The objective of this work is the comparative study of different osmotic treatments at 37 °C on the quality and shelf life of chilled sea bass fillets. Fish fillets were treated using osmotic solutions consisting of oligofructose (40%–50%–60%) and 5% NaCl with (BP/OT) and without (OT) former antioxidant enrichment by using Rosa damascena distillation by-products. Water activity decreased to approximately 0.95 after 330 minutes of osmotic treatment. Untreated and osmotically treated fish fillets (BP/OT) and (OT) were subsequently stored at 5 °C and their quality was evaluated based on microbial growth and lipid oxidation. Osmotic treatment extended significantly the shelf life of fish in terms of microbial growth; however, it also accelerated its lipid oxidation. The impregnation of Rosa damascena phenolics not only counterbalanced this negative effect, but led to a more than four-fold increase of the shelf life of sea bass, as compared to the untreated samples.
The History Goes On: Century Long Study of Romano’s Star
Authors: Maryeva Olga , Viotti Roberto F. , Koenigsberger Gloria , Calabresi Massimo , Rossi Corinne , Gualandi Roberto
Published: September 2019

GR 290 (M 33 V0532 = Romano’s Star) is a unique variable star in the M33 galaxy, which simultaneously displays variability typical for luminous blue variable (LBV) stars and physical parameters typical for nitrogen-rich Wolf-Rayet (WR) stars (WN). As of now, GR 290 is the first object which is confidently classified as a post-LBV star. In this paper, we outline the main results achieved from extensive photometric and spectroscopic observations of the star: the structure and chemical composition of its wind and its evolution over time, the systematic increase of the bolometric luminosity during the light maxima, the circumstellar environment. These results show that the current state of Romano’s Star constitutes a fundamental link in the evolutionary path of very massive stars.
The Expanded SWEET Gene Family Following Whole Genome Triplication in Brassica rapa
Authors: Wei Yanping , Xiao Dong , Zhang Changwei , Hou Xilin
Published: September 2019

The SWEET family, which includes transcripts of a cohort of plant hexose and sucrose transporters, is considered key to improving crop stress tolerance and yield through its role in manipulating the carbohydrate partitioning process. The functions and regulatory roles of this gene family are variable among different species; thus, to determine these roles, more species-specific information is needed. Brassica rapa displays complicated regulation after a whole-genome triplication (WGT) event, which provides enormous advantages for use in genetic studies, thus it is an ideal model for exploring the functional and regulatory roles of SWEETs from a genetic perspective. In this study, the results of a homology search and phylogenetic relationship analysis revealed the evolutionary footprint of SWEETs among different plant taxa, which showed that plant SWEETs may have originated from Clade II and then expanded from vascular plants. The amino acid sequence characteristics and an analysis of the exon-intron structure of BrSWEETs duplicates clarified that SWEETs retention occurred after a WGT event in B. rapa. An analysis of the transcriptional levels of BrSWEETs in different tissues identified the expression differences among duplicated co-orthologs. In addition, qRT-PCR indicated that the BrSWEETs’ co-orthologs were varied in their stress responses. This study greatly enriches our knowledge of SWEETs in the B. rapa species, which will contribute to future studies on the Brassica-specific regulatory pathways and to creating genetic innovations.
Thyroid Cancer in the Pediatric Population
Authors: Paulson Vera A. , Rudzinski Erin R. , Hawkins Douglas S.
Published: September 2019

Thyroid cancer is rare in the pediatric population, but thyroid carcinomas occurring in children carry a unique set of clinical, pathologic, and molecular characteristics. In comparison to adults, children more often present with aggressive, advanced stage disease. This is at least in part due to the underlying biologic and molecular differences between pediatric and adult thyroid cancer. Specifically, papillary thyroid carcinoma (which accounts for approximately 90% of pediatric thyroid cancer) has a high rate of gene fusions which influence the histologic subtypes encountered in pediatric thyroid tumors, are associated with more extensive extrathyroidal disease, and offer unique options for targeted medical therapies. Differences are also seen in pediatric follicular thyroid cancer, although there are few studies of non-papillary pediatric thyroid tumors published in the literature due to their rarity, and in medullary carcinoma, which is most frequently diagnosed in the pediatric population in the setting of prophylactic thyroidectomies for known multiple endocrine neoplasia syndromes. The overall shift in the spectrum of histotypes and underlying molecular alterations common in pediatric thyroid cancer is important to recognize as it may directly influence diagnostic test selection and therapeutic recommendations.
Geographical Considerations in Site Selection for Small Modular Reactors in Saskatchewan
Authors: Almalki Raid , Piwowar Joseph , Siemer Julia
Published: September 2019

Saskatchewan is one of Canada’s highest emitters of greenhouse gases, largely due to the burning of lignite coal to generate electricity. The province is also the world’s second largest producer of uranium. This research was intended to establish a process for evaluating geographical considerations in site selection for small modular reactors (SMRs) in Saskatchewan. SMRs are the next generation of electrical power, producing less than 300 megawatts (MW) and featuring a basic design that offers enhanced safety, health, and environmental benefits compared to traditional reactors. Selecting an SMR site is a two-stage process: (i) Identifying candidate site locations based solely on available geographical, economic, and logistical data—an objective process—and (ii) refining the potential locations based on public perceptions, social conventions, and political will—a subjective process. This study focused on the objective geographical considerations in SMR site selection in Saskatchewan. The study areas were subjected to a multi-criteria decision analysis based on specific criteria drawn from various Canadian federal regulation documents. Criteria weights were assigned using the analytical hierarchy process, with results for two different types of criteria weights applied for the purpose of demonstration. Three distinct cases of criteria fuzzy standardization were conducted to assign spatial suitability values for all the criteria. Spatial decision-making models were implemented in a geographic information system to identify candidate sites. Geographical maps constructed from the findings showed suitable sites for SMRs, ranging from very suitable to unsuitable based on the geographical analysis of the study area.
Trends in Diabetes Prevalence, Awareness, Treatment and Control in Yangon Region, Myanmar, Between 2004 and 2014, Two Cross-Sectional Studies
Authors: Aung Wai Phyo , Bjertness Espen , Htet Aung Soe , Stigum Hein , Kjøllesdal Marte Karoline Råberg
Published: September 2019

Myanmar is currently facing the burden of non-communicable diseases due to changes in lifestyle and dietary patterns linked to socio-economic development. However, evidence is scarce about changes in the prevalence of diabetes mellitus (DM) over time. We aimed to investigate changes in the prevalence, awareness, treatment and control of DM from 2004 to 2014, among adults aged 25–74 years, in the Yangon region. Two cross-sectional household-based studies, according to World Health Organization STEPwise approach to surveillance (WHO STEPS) methodology, were conducted in 2004 (n = 4448) and 2014 (n = 1372). The overall age-standardized prevalence of DM was 8.3% (95% CI 6.5–10.6) in 2004 and 10.2% (7.6–13.6) in 2014 (p = 0.296). The DM prevalence increased between the study years among elderly participants only, from 14.6% (11.7–18.1) to 31.9% (21.1–45.0) (p = 0.009). Awareness of having DM increased from 44.3% (39.2, 49.6) to 69.4% (62.9–75.2) (p < 0.001). Among participants who were aware of having DM, the proportion under treatment increased from 55.1% (46.8–63.1) to 68.6% (61.5–74.8) (p = 0.015). There was no change in proportion with controlled DM. Adjusted for age, sex and education, mean fasting plasma glucose levels in 2014 were 0.56 mmol/L (0.26–0.84) higher than in 2004. Preventive measures to halt future increases in DM prevalence and to increase the detection of undiagnosed DM cases are needed.
Exploration of Medical Trajectories of Stroke Patients Based on Group-Based Trajectory Modeling
Authors: Chien Ting-Ying , Lee Mei-Lien , Wu Wan-Ling , Ting Hsien-Wei
Published: September 2019

A high mortality rate is an issue with acute cerebrovascular disease (ACVD), as it often leads to a high medical expenditure, and in particular to high costs of treatment for emergency medical conditions and critical care. In this study, we used group-based trajectory modeling (GBTM) to study the characteristics of various groups of patients hospitalized with ACVD. In this research, the patient data were derived from the 1 million sampled cases in the National Health Insurance Research Database (NHIRD) in Taiwan. Cases who had been admitted to hospitals fewer than four times or more than eight times were excluded. Characteristics of the ACVD patients were collected, including age, mortality rate, medical expenditure, and length of hospital stay for each admission. We then performed GBTM to examine hospitalization patterns in patients who had been hospitalized more than four times and fewer than or equal to eight times. The patients were divided into three groups according to medical expenditure: high, medium, and low groups, split at the 33rd and 66th percentiles. After exclusion of unqualified patients, a total of 27,264 cases (male/female = 15,972/11,392) were included. Analysis of the characteristics of the ACVD patients showed that there were significant differences between the two gender groups in terms of age, mortality rate, medical expenditure, and total length of hospital stay. In addition, the data were compared between two admissions, which included interval, outpatient department (OPD) visit after discharge, OPD visit after hospital discharge, and OPD cost. Finally, the differences in medical expenditure between genders and between patients with different types of stroke—ischemic stroke, spontaneous intracerebral hemorrhage (sICH), and subarachnoid hemorrhage (SAH)—were examined using GBTM. Overall, this study employed GBTM to examine the trends in medical expenditure for different groups of stroke patients at different admissions, and some important results were obtained. Our results demonstrated that the time interval between subsequent hospitalizations decreased in the ACVD patients, and there were significant differences between genders and between patients with different types of stroke. It is often difficult to decide when the time has been reached at which further treatment will not improve the condition of ACVD patients, and the findings of our study may be used as a reference for assessing outcomes and quality of care for stroke patients. Because of the characteristics of NHIRD, this study had some limitations; for example, the number of cases for some diseases was not sufficient for effective statistical analysis.
Occupational Class Differences in Long-Term Sickness Absence Due to Breast Cancer during 2005–2013: A Population-Based Study among Finnish Women
Authors: Suur-Uski Johanna , Pekkala Johanna , Blomgren Jenni , Pietiläinen Olli , Rahkonen Ossi , Mänty Minna
Published: September 2019

Breast cancer is the most common cancer among women in Western countries with clear socioeconomic differences. Higher occupational class is associated with higher breast cancer incidence but with better survival from the disease, whereas lower occupational class is associated with higher risk of sickness absence. We are not aware of previous studies examining changes over time in occupational class differences in sickness absence due to breast cancer. This paper focuses on occupational class differences in the incidence and duration of sickness absence due to breast cancer over the period of 2005–2013. Age-adjusted occupational class differences in the cumulative incidence and duration of sickness absence due to breast cancer were calculated utilising a nationally representative 70% random sample of employed Finnish women aged 35–64 years (yearly N varying between 499,778 and 519,318). The results show that higher occupational class was associated with higher annual cumulative incidence of sickness absence due to breast cancer. Lower occupational class was associated with longer duration of absence. Occupational class differences in both cumulative incidence and duration of absence remained broadly stable. As a conclusion, these results suggest that measures should be targeted particularly to promotion of work capacity among employees with breast cancer in lower occupational classes.
Flood Management in Aqala through an Agent-Based Solution and Crowdsourcing Services in an Enterprise Geospatial Information System
Authors: Eivazy Hooshang , Malek Mohammad Reza
Published: September 2019

Propagating crowdsourcing services via a wireless network can be an appropriate solution to using the potential of crowds in crisis management processes. The present study aimed to deploy crowdsourcing services properly to spatial urgent requests. Composing such atomic services can conquer sophisticated crisis management. In addition, the conducted propagated services guide people through crisis fields and allow managers to use crowd potential appropriately. The use of such services requires a suitable automated allocation method, along with a proper approach to arranging the sequence of propagating services. The solution uses a mathematical framework in the context of a GIS (Geospatial Information System) in order to construct an allocation approach. Solution elements are set out in a multi-agent environment structure, which simulate disaster field objects. Agents which are dynamically linked to objects in a crisis field, interact with each other in a competitive environment, and the results in forming crowdsourcing services are used to guide crowds in the crisis field via the crowdsourcing services. The present solution was implemented through a proper data schema in a powerful geodatabase, along with various users with specialized interfaces. Finally, a solution and crowdsourcing service was tested in the context of a GIS in the 2019 Aqala flood disaster in Iran and other complement scenarios. The allocating performance and operation of other system elements were acceptable and reduced indicators, such as rescuer fatigue and delay time. Crowdsourcing service was positioned well in the solution and provided good performance among the elements of the Geospatial Information System.
Proteomic Analysis in Morquio A Cells Treated with Immobilized Enzymatic Replacement Therapy on Nanostructured Lipid Systems
Authors: Álvarez J. Víctor , Bravo Susana B. , García-Vence María , De Castro María J. , Luzardo Asteria , Colón Cristóbal , Tomatsu Shunji , Otero-Espinar Francisco J. , Couce María L.
Published: September 2019

Morquio A syndrome, or mucopolysaccharidosis type IVA (MPS IVA), is a lysosomal storage disease due to mutations in the N-acetylgalactosamine-6-sulfatase (GALNS) gene. Systemic skeletal dysplasia and the related clinical features of MPS IVA are due to disruption of cartilage and its extracellular matrix, leading to an imbalance of growth. Enzyme replacement therapy (ERT) with recombinant human GALNS, alpha elosulfase, provides a systemic treatment. However, this therapy has a limited impact on skeletal dysplasia because the infused enzyme cannot penetrate cartilage and bone. Therefore, an alternative therapeutic approach to reach the cartilage is an unmet challenge. We have developed a new drug delivery system based on a nanostructure lipid carrier with the capacity to immobilize enzymes used for ERT and to target the lysosomes. This study aimed to assess the effect of the encapsulated enzyme in this new delivery system, using in vitro proteomic technology. We found a greater internalization of the enzyme carried by nanoparticles inside the cells and an improvement of cellular protein routes previously impaired by the disease, compared with conventional ERT. This is the first qualitative and quantitative proteomic assay that demonstrates the advantages of a new delivery system to improve the MPS IVA ERT.
Norvaline Restores the BBB Integrity in a Mouse Model of Alzheimer’s Disease
Authors: Polis Baruh , Gurevich Vyacheslav , Assa Michael , Samson Abraham O.
Published: September 2019

Alzheimer’s disease (AD) is a chronic neurodegenerative disorder and the leading cause of dementia. The disease progression is associated with the build-up of amyloid plaques and neurofibrillary tangles in the brain. However, besides the well-defined lesions, the AD-related pathology includes neuroinflammation, compromised energy metabolism, and chronic oxidative stress. Likewise, the blood–brain barrier (BBB) dysfunction is suggested to be a cause and AD consequence. Accordingly, therapeutic targeting of the compromised BBB is a promising disease-modifying approach. We utilized a homozygous triple-transgenic mouse model of AD (3×Tg-AD) to assess the effects of L-norvaline on BBB integrity. We scrutinized the perivascular astrocytes and macrophages by measuring the immunopositive profiles in relation to the presence of β-amyloid and compare the results with those found in wild-type animals. Typically, 3×Tg-AD mice display astroglia cytoskeletal atrophy, associated with the deposition of β-amyloid in the endothelia, and declining nitric oxide synthase (NOS) levels. L-norvaline escalated NOS levels, then reduced rates of BBB permeability, amyloid angiopathy, microgliosis, and astrodegeneration, which suggests AD treatment agent efficacy. Moreover, results undergird the roles of astrodegeneration and microgliosis in AD-associated BBB dysfunction and progressive cognitive impairment. L-norvaline self-evidently interferes with AD pathogenesis and presents a potent remedy for angiopathies and neurodegenerative disorders intervention.
Magnesium Sulfate Mitigates the Progression of Monocrotaline Pulmonary Hypertension in Rats
Authors: Chang Chao-Yuan , Shih Hung-Jen , Huang I-Tao , Tsai Pei-Shan , Chen Kung-Yen , Huang Chun-Jen
Published: September 2019

We investigated whether magnesium sulfate (MgSO4) mitigated pulmonary hypertension progression in rats. Pulmonary hypertension was induced by a single intraperitoneal injection of monocrotaline (60 mg/kg). MgSO4 (100 mg/kg) was intraperitoneally administered daily for 3 weeks, from the seventh day after monocrotaline injection. Adult male rats were randomized into monocrotaline (MCT) or monocrotaline plus MgSO4 (MM) groups (n = 15 per group); control groups were maintained simultaneously. For analysis, surviving rats were euthanized on the 28th day after receiving monocrotaline. The survival rate was higher in the MM group than in the MCT group (100% versus 73.3%, p = 0.043). Levels of pulmonary artery wall thickening, α-smooth muscle actin upregulation, right ventricular systolic pressure increase, and right ventricular hypertrophy were lower in the MM group than in the MCT group (all p < 0.05). Levels of lipid peroxidation, mitochondrial injury, inflammasomes and cytokine upregulation, and apoptosis in the lungs and right ventricle were lower in the MM group than in the MCT group (all p < 0.05). Notably, the mitigation effects of MgSO4 on pulmonary artery wall thickening and right ventricular hypertrophy were counteracted by exogenous calcium chloride. In conclusion, MgSO4 mitigates pulmonary hypertension progression, possibly by antagonizing calcium.
Effects of Tocilizumab, an Anti-Interleukin-6 Receptor Antibody, on Serum Lipid and Adipokine Levels in Patients with Rheumatoid Arthritis
Authors: Hoffman Elinoar , Rahat Michal A. , Feld Joy , Elias Muna , Rosner Itzhak , Kaly Lisa , Lavie Idit , Gazitt Tal , Zisman Devy
Published: September 2019

Patients with rheumatoid arthritis (RA) are at increased risk of cardiovascular disease. Dyslipidemia is a known adverse effect of tocilizumab (TCZ), an anti-interleukin-6 receptor antibody used in RA treatment. We aimed to assess the effect of TCZ on lipid profile and adipokine levels in RA patients. Height, weight, disease activity scores, lipid profile and atherogenic indices (AI), leptin, adiponectin, resistin, interleukin-6, and high-sensitivity C-reactive protein (CRP) were measured before and four months after initiation of TCZ in 40 RA patients and 40 healthy controls. Following TCZ treatment, total cholesterol, high density lipoprotein (HDL), and triglycerides were significantly elevated, but no significant changes in weight, body mass index (BMI), low density lipoprotein (LDL), and AI were observed. Compared with controls, significantly higher adiponectin levels were measured in the RA group at baseline. Following TCZ treatment, resistin levels and the leptin-to-adiponectin ratio increased, adiponectin levels decreased, and leptin levels remained unchanged. No correlation was found between the change in adipokine serum levels and changes in the disease activity indices, nor the lipid profile. In conclusion, the changes observed suggest a protective role for TCZ on the metabolic and cardiovascular burden associated with RA, but does not provide a mechanistic explanation for this phenomenon.
Wound Healing: In Vitro and In Vivo Evaluation of a Bio-Functionalized Scaffold Based on Hyaluronic Acid and Platelet-Rich Plasma in Chronic Ulcers
Authors: De Angelis Barbara , D’Autilio Margarida Fernandes Lopes Morais , Orlandi Fabrizio , Pepe Giampiero , Garcovich Simone , Scioli Maria Giovanna , Orlandi Augusto , Cervelli Valerio , Gentile Pietro
Published: September 2019

Chronic ulcers are characterized by loss of substance without a normal tendency towards spontaneous healing. The Wound Bed Preparation Guideline advises that after diagnosis, the expert should correct the biological state of the ulcer micro-environment based on TIME principles (Tissue, Infection, Moisture balance, Epidermal). There are many ways to treat such ulcers, for example through use of advanced dressings, negative pressure, surgical toilets, dermal substitutes, autologous skin grafting, and free or local flaps. In vitro and in vivo pre-clinical models hold widely acknowledged potential yet complex limitations. Tissue bioengineering could be an ideal approach to foster innovative strategies in wound healing. Our observational study reports on an in vitro and in vivo evaluation of a bio-functionalized scaffold composed of platelet-rich plasma (PRP) and hyaluronic acid (HA) used in 182 patients affected by chronic ulcers (diabetic and vascular), comparing the results with a control group of 182 patients treated with traditional dressings (HA alone). After 30 days the patients who had undergone the combined treatment (PRP + HA), showed 96.8% ± 1.5% re-epithelialization, as compared to 78.4% ± 4.4% in the control group (HA only). Within 80 days, they had 98.4% ± 1.3% re-epithelialization as compared to 87.8% ± 4.1% in the control group (HA only; p < 0.05). No local recurrence was observed during the follow-up period. PRP + HA treatment showed stronger regenerative potential in terms of epidermal proliferation and dermal renewal compared with HA alone.
The Increase of Osteoporotic Hip Fractures and Associated One-Year Mortality in Poland: 2008–2015
Authors: Glinkowski Wojciech , Narloch Jerzy , Krasuski Krzysztof , Śliwczyński Andrzej
Published: September 2019

Introduction: Hip fractures are a worldwide public health issue associated with significant mortality. Previous Polish studies reported an increasing trend in the number of hip fractures for both men and women, although lower than most other European countries. Materials and Methods: The Polish National Database was analyzed to examine osteoporotic hip fractures in the population aged 50 and over. Hip fracture incidence, rate, one-year mortality, and postoperative length of hospitalization were analyzed using the national health system data. Hospital discharge registry ICD-10 codes were reviewed from 2008 to 2015. Results: The incidence of hip fractures increased in both women and men by 19.4% and 14.2%, respectively. The female to male fracture ratio was 2.46. Mean postoperative hospitalization decreased from 13.6 to 11.2 days. The one-year mortality ranged between 30.45% to 32.8% for men and 26.2% to 28% for women. Of note, women aged 80–89 had the highest one-year mortality, 50.7%–55.4% after femoral neck fracture and 53%–58.5% after a pertrochanteric fracture. Conclusions: Hip fractures in Poland are increasingly more prevalent in the aging population. The unfavorable trends observed in this study indicate higher annual mortality after hip fracture, compared with other European countries.
Challenges and Perspectives in Nutritional Counselling and Nursing: A Narrative Review
Authors: Vasiloglou Maria F. , Fletcher Jane , Poulia Kalliopi-Anna
Published: September 2019

Nutritional counselling has been recognised as the first line approach in the management of numerous chronic diseases. Though usually carried out by dietitians, nutritional counselling may be used by nurses, or other healthcare professionals to improve nutritional status and meet healthcare goals. Healthcare professionals require training and education to facilitate a patient centred approach to effective counselling. Advances in digital technology have the potential to improve access to nutritional counselling for some patients such as those in primary care. However, caution is required to ensure that valuable interpersonal relationships are not lost, as these form the cornerstone of effective nutritional counselling. The aim of this narrative review is to explore aspects of effective nutritional counselling, including advances in e-counselling and areas where nursing input in nutritional counselling might enhance overall nutritional care.
Multiple-Output DC-DC Converters with a Reduced Number of Active and Passive Components
Authors: Turhan Mert , Castellanos Juan C. , Hendrix Marcel A. M. , Duarte Jorge L. , Lomonova Elena A.
Published: September 2019

Multiple-output converters have been widely used where individual outputs are required. Compared with conventional separate converters, the advantage of multiple outputs is to have a lower number of active and passive components. In this paper, first, a pulse-width-modulation (PWM)-pulse-frequency-modulation (PFM) method is used for two-output converters that have only one coil and one active switch. Secondly, three-output converter topologies are proposed where the third output is controlled by phase delay (PD). These converters need only two coils and two active switches to regulate three outputs. How to obtain PD at different switching frequencies is discussed next, and a PWM-PFM-PD controlled five-output buck converter is presented. The proposed solution uses only two active switches and two magnetic cores to adjust five-output voltages independently. A modeling and digital control method are proposed in order to regulate the five output voltages. A prototype circuit with independent 15 V/1.5 A, 12 V/1.5 A, 5 V/0.8 A, −5 V/0.6 A and 3.3 V/0.45 A outputs is assembled to validate the analysis, and it was proved that it regulates the output voltages at different loads.
Effectiveness and Compatibility of a Novel Sustainable Method for Stone Consolidation Based on Di-Ammonium Phosphate and Calcium-Based Nanomaterials
Authors: Pesce Cecilia , Moretto Ligia M. , Orsega Emilio F. , Pesce Giovanni L. , Corradi Marco , Weber Johannes
Published: September 2019

External surfaces of stones used in historic buildings often carry high artistic value and need to be preserved from the damages of time, especially from the detrimental effects of the weathering. This study aimed to test the effectiveness and compatibility of some new environmentally-friendly materials for stone consolidation, as the use thereof has been so far poorly investigated. The treatments were based on combinations of an aqueous solution of di-ammonium phosphate (DAP) and two calcium-based nanomaterials, namely a commercial nanosuspension of Ca(OH)2 and a novel nanosuspension of calcite. The treatments were applied to samples of two porous stones: a limestone and a sandstone. The effectiveness of the treatments was assessed using scanning electron microscopy coupled with energy-dispersive X-ray spectroscopy, Fourier-transform infrared spectroscopy, ultrasound pulse velocity test, colour measurements, and capillary water absorption test. The results suggest that the combined use of DAP and Ca-based nanosuspensions can be advantageous over other commonly used consolidants in terms of retreatability and physical-chemical compatibility with the stone. Some limitations are also highlighted, such as the uneven distribution and low penetration of the consolidants.
Comparison of Cinchona Catalysts Containing Ethyl or Vinyl or Ethynyl Group at Their Quinuclidine Ring
Authors: Nagy Sándor , Fehér Zsuzsanna , Dargó Gergő , Barabás Júlia , Garádi Zsófia , Mátravölgyi Béla , Kisszékelyi Péter , Dargó Gyula , Huszthy Péter , Höltzl Tibor , Balogh György Tibor , Kupai József
Published: September 2019

Numerous cinchona organocatalysts with different substituents at their quinuclidine unit have been described and tested, but the effect of those saturation has not been examined before. This work presents the synthesis of four widely used cinchona-based organocatalyst classes (hydroxy, amino, squaramide, and thiourea) with different saturation on the quinuclidine unit (ethyl, vinyl, ethynyl) started from quinine, the most easily available cinchona derivative. Big differences were found in basicity of the quinuclidine unit by measuring the pKa values of twelve catalysts in six solvents. The effect of differences was examined by testing the catalysts in Michael addition reaction of pentane-2,4-dione to trans-β-nitrostyrene. The 1.6–1.7 pKa deviation in basicity of the quinuclidine unit did not result in significant differences in yields and enantiomeric excesses. Quantum chemical calculations confirmed that the ethyl, ethynyl, and vinyl substituents affect the acid-base properties of the cinchona-thiourea catalysts only slightly, and the most active neutral thione forms are the most stable tautomers in all cases. Due to the fact that cinchonas with differently saturated quinuclidine substituents have similar catalytic activity in asymmetric Michael addition application of quinine-based catalysts is recommended. Its vinyl group allows further modifications, for instance, recycling the catalyst by immobilization.
Variational Partitioned Runge–Kutta Methods for Lagrangians Linear in Velocities
Authors: Tyranowski Tomasz M. , Desbrun Mathieu
Published: September 2019

In this paper, we construct higher-order variational integrators for a class of degenerate systems described by Lagrangians that are linear in velocities. We analyze the geometry underlying such systems and develop the appropriate theory for variational integration. Our main observation is that the evolution takes place on the primary constraint and the “Hamiltonian” equations of motion can be formulated as an index-1 differential-algebraic system. We also construct variational Runge–Kutta methods and analyze their properties. The general properties of Runge–Kutta methods depend on the “velocity” part of the Lagrangian. If the “velocity” part is also linear in the position coordinate, then we show that non-partitioned variational Runge–Kutta methods are equivalent to integration of the corresponding first-order Euler–Lagrange equations, which have the form of a Poisson system with a constant structure matrix, and the classical properties of the Runge–Kutta method are retained. If the “velocity” part is nonlinear in the position coordinate, we observe a reduction of the order of convergence, which is typical of numerical integration of DAEs. We verified our results through numerical experiments for various dynamical systems.
New Inequalities of Weaving K-Frames in Subspaces
Authors: Xiang Zhong-Qi
Published: September 2019

In the present paper, we obtain some new inequalities for weaving K-frames in subspaces based on the operator methods. The inequalities are associated with a sequence of bounded complex numbers and a parameter λ ∈ R . We also give a double inequality for weaving K-frames with the help of two bounded linear operators induced by K-dual. Facts prove that our results cover those recently obtained on weaving frames due to Li and Leng, and Xiang.
Naturopathy as a Model of Prevention-Oriented, Patient-Centered Primary Care: A Disruptive Innovation in Health Care
Authors: Bradley Ryan , Harnett Joanna , Cooley Kieran , McIntyre Erica , Goldenberg Joshua , Adams Jon
Published: September 2019

Background and Objective: The concept of a “disruptive innovation,” recently extended to health care, refers to an emerging technology that represents a new market force combined with a new value system, that eventually displaces some, or all, of the current leading “stakeholders, products and strategic alliances.” Naturopathy is a distinct system of traditional and complementary medicine recognized by the World Health Organization (WHO), emerging as a model of primary care. The objective here is to describe Naturopathy in the context of the criteria for a disruptive innovation. Methods: An evidence synthesis was conducted to evaluate Naturopathy as a potentially disruptive technology according to the defining criteria established by leading economists and health technology experts: (1) The innovation must cure disease; (2) must transform the way medicine is practiced; or (3) have an impact that could be disruptive or sustaining, depending on how it is integrated into the current healthcare marketplace. Results: The fact that Naturopathy de-emphasizes prescription drug and surgical interventions in favor of nonpharmacological health promotion and self-care could disrupt the present economic model that fuels health care costs. The patient-centered orientation of Naturopathy, combined with an emphasis on preventive behaviors and popular complementary and integrative health services like natural products, mind and body therapies, and other therapies not widely represented in current primary care models increase the likelihood for disruption. Conclusions: Because of its patient-centered approach and emphasis on prevention, naturopathy may disrupt or remain a durable presence in healthcare delivery depending on policymaker decisions.
Vitamin A Enhances Macrophages Activity Against B16-F10 Malignant Melanocytes: A New Player for Cancer Immunotherapy?
Authors: Oliveira Sofia , Costa José , Faria Isabel , Guerreiro Susana G. , Fernandes Rúben
Published: September 2019

Background and objectives: The incidence of cutaneous melanoma has been increasing. Melanoma is an aggressive form of skin cancer irresponsive to radiation and chemotherapy, rendering this cancer a disease with poor prognosis: In order to surpass some of the limitations addressed to melanoma treatment, alternatives like vitamins have been investigated. In the present study, we address this relationship and investigate the possible role of vitamin A. Materials and Methods: We perform a co-culture assay using a macrophage cell model and RAW 264.7 from mouse, and also a murine melanoma cell line B16-F10. Macrophages were stimulated with both Escherichia coli lipopolysaccharides (LPS) as control, and also with LPS plus vitamin A. Results: Using B16-F10 and RAW 264.7 cell lines, we were able to demonstrate that low concentrations of vitamin A increase cytotoxic activity of macrophages, whereas higher concentrations have the opposite effect. Conclusion: These findings can constitute a new point of view related to immunostimulation by nutrients, which may be considered one major preventive strategy by enhancing the natural defense system of the body.
Oxidative Leaching of Zinc and Alkalis from Iron Blast Furnace Sludge
Authors: Soria-Aguilar Ma. de Jesus , Davila-Pulido Gloria Ivone , Carrillo-Pedroza Francisco Raul , Gonzalez-Ibarra Adrian Amilcare , Picazo-Rodriguez Nallely , Lopez-Saucedo Felipe de Jesus , Ramos-Cano Juan
Published: September 2019

The sludge from a wet-off gas cleaning system of the iron blast furnace (BF) contains significant amounts of iron; however, they cannot be recycled due to their high content of zinc and alkalis. These compounds are detrimental to the optimal performance of iron and steelmaking furnaces. In this work, a comparative laboratory study to reduce zinc and alkali contained in the blast furnace sludge (BFS) is presented. The effect of leaching parameters such as oxidant (i.e., ferric ion, oxygen or ozone), aqueous solution media (i.e., 0.2 M NH4Cl, 0.2 M HCl and 0.1 M H2SO4) and temperature (i.e., 27 and 80 °C) on Zn and alkalis (Na2O and K2O) removal were studied by applying an experimental design. The results obtained show that Zn and K2O removal of 85% and 75% were achieved under the following conditions: Ozone as an oxidant agent and 0.1 M H2SO4 as an aqueous medium, temperature had no significant effect. The results are supported by thermodynamic diagrams and the possible chemical reactions are mentioned. Although the results also indicate that leaching under the above conditions dissolves up to 9% of iron, this loss is much less than leaching without the oxidizing conditions generated by the ozone. The BFS obtained from this treatment could be recirculated to the iron or steelmaking processes to recover iron values.
Piezoelectric Impedance-Based Non-Destructive Testing Method for Possible Identification of Composite Debonding Depth
Authors: Na Wongi S. , Baek Jongdae
Published: September 2019

Detecting the depth and size of debonding in composite structures is essential for assessing structural safety as it can weaken the structure possibly leading to a failure. As composite materials are used in various fields up to date including aircrafts and bridges, inspections are carried out to maintain structural integrity. Although many inspection methods exist for detection damage of composites, most of the techniques require trained experts or a large equipment that can be time consuming. In this study, the possibility of using the piezoelectric material-based non-destructive method known as the electromechanical impedance (EMI) technique is used to identify the depth of debonding damage of glass epoxy laminates. Laminates with various thicknesses were prepared and tested to seek for the possibility of using the EMI technique for identifying the depth of debonding. Results show promising outcome for bringing the EMI technique a step closer for commercialization.
Fabrication and Study on Magnetic-Optical Properties of Ni-Doped ZnO Nanorod Arrays
Authors: Wang Wei , Hui Shoulong , Zhang Fuchun , Wang Xiaoyang , Zhang Shuili , Yan Junfeng , Zhang Weihu
Published: September 2019

Zn1-xNixO nanorod arrays were prepared on Si substrates by magnetron sputtering and hydrothermal methods at 100 °C. We studied the effects of doped concentration and hydrothermal growth conditions on the crystal structure, morphology, photoluminescence, and magnetic properties of Zn1-xNixO nanorod arrays. The research results show that the Zn1-xNixO nanorod have the hexagonal wurtzite structure without the appearance of the second phase, and all samples have a highly preferred orientation of a (002) crystal face. The Zn1-xNixO nanorod arrays exhibit obvious room temperature ferromagnetism with saturation magnetization at 4.2 × 10−4 emu/g, the residual magnetization is 1.3 × 10−4 emu/g and the coercive field is 502 Oe, and also excellent luminescent properties with seven times greater luminous intensity than that of ZnO nanorod arrays. The redshift of the ultraviolet emission peak was found by Ni2+ doping. We further explained the source and essence of the magnetic properties of Zn1-xNixO nanorod arrays and deemed that the magnetic moment mainly comes from the hybrid electron exchange of O 2p and Ni 3d state.