bluuebunny/crossref_metadata_2025 huggingface dataset:
Os novos museus e a estética na contemporaneidade
Authors:   Universidade de São Paulo, Meira Marcel Ronaldo Morelli de
Published: May 2023

De acordo com a convenção da crítica, a “cultura dos museus” teve início em 1977, com a inauguração do Museu Nacional de Arte Moderna do Centro Georges Pompidou (o Beaubourg), em Paris, consolidando-se com a filial do Museu Guggenheim, na cidade de Bilbao, em 1997, do arquiteto Frank Gehry, e atigindo sua nova fase de expansão ao Oriente, nos anos 2000, com os projetos de franquia do Beaubourg, em Xangai, na China, e do Novo Louvre, em Abu Dhabi, nos Emirádos Árabes, com inaugurações previstas para 2010 e 2012. Para alguns autores, a eclosão dos museus pode ser considerada como sintomática da cultura ocidental dos anos 80, na qual os freqüentadores das exposições passaram a procurar cada vez mais experiências ligadas as chamadas diversões de massa, ao invés da “apropriação meticulosa” de conhecimento cultural. O papel assumido pelos museus passou então a ser progressivamente maior na economia das cidades, fazendo com que o sucesso rentável de qualquer cidade passasse a depender substancialmente dos atrativos de seus museus.
As transformações na arquitetura rural paulista pré-moderna
Authors:   Universidade Estadual de Campinas, Augusto Marcelo Gaudio
Published: May 2023

Este texto pretende explorar as diversas influências que a casa paulista rural recebeu no decorrer dos séculos. A arquitetura paulista foi por muito tempo tratada com pouca atenção na história da arquitetura brasileira, talvez pelo seu menor refinamento em relação ao barroco mineiro ou à arquitetura colonial do nordeste. É apenas com Luís Saia, em meados do século XX, que as grosseiras casas de taipa se tornam relevantes. Desde então, o estudo do legado desta cultura material foi tema de vários autores (BENINCASA:2003; FERRÃO:2005; HOMEM:1998; KATINSKY:1976; LEMOS:1999; SILVA:2006). Estes tendem a estabelecer períodos diferentes para a arquitetura paulista, porém frequentemente divergem ao organizar segmentações aos diferentes momentos que tal arquitetura apresenta. Estas divisões são baseadas a partir de diversos condicionantes: ciclos econômicos, a movimentação das populações, ou mesmo o tempo.
Interlocuções entre arquitetura e arte: uma leitura do manifesto “The Manhattan Transcripts” de Bernard Tschumi
Authors:   Universidade de São Paulo, Solfa Marilia
Published: May 2023

Uma manifestação autônoma é aquela que se autogoverna, segue um conjunto de leis internas e pode ser estudada isoladamente de seu contexto. Dizer que a arquitetura é uma manifestação autônoma é tomá-la como uma área do conhecimento que não é atingida pelas forças externas ao seu campo de atuação. Mas a arquitetura se vincula com questões urbanas, com as forças sociais, econômicas e culturais em curso. Por isso, no início dos anos 1970, o arquiteto suíço - francês Bernard Tschumi defendia que, para além de tratar de suas próprias preocupações e problemas intrínsecos (como conceber espaços harmônicos, aprazíveis e ao mesmo tempo funcionais), a arquitetura também deveria partilhar preocupações e problemas com outros campos do saber.
A face de Judas: de Rubens ao Aleijadinho e mestre Ataíde
Authors:   Universidade Estadual de Londrina, Leite Pedro Queiroz
Published: May 2023

As pesquisas que realizamos há alguns anos têm como objetivo compor um inventário dos livros com estampas, ou mesmo das gravuras avulsas, que circularam em Minas Gerais entre meados do século XVIII e as primeiras décadas do XIX. Para tal, selecionamos como fundos de pesquisa prioritários os acervos, públicos e privados, existentes nas cidades de Ouro Preto e Mariana, por serem estas as principais concentrações urbanas da capitania no período em recorte. Realizadas já várias pesquisas neste sentido, nossa intenção é, através deste reconhecimento visual, procurar identificar algumas imagens que possam ter servido de modelos para a pintura e a talha da região destacada. Pois, como é sabido, a circulação de estampas e sua conversão em modelos para outros artistas – modelos passíveis de novos arranjos, por acréscimos ou supressões frente aos originais – é um fato tão antigo quanto bem documentado.
A I Bienal de São Paulo ou Pré Bienal de 1970
Authors:   Universidade Estadual de Campinas, Zago Renata Cristina de Oliveira Maia
Published: May 2023

O presente artigo pretende discorrer sobre a I Bienal Nacional de São Paulo ou Pré- Bienal que aconteceu em 1970 e sua importância no cenário cultural da época. Para isso, desenvolvemos uma pesquisa pautada primordialmente em dados resgatados da documentação histórica gerada pelo evento (incluindo-se aqui também os artigos de jornais publicados pela imprensa do período) e conservada no Arquivo Histórico Wanda Svevo da Fundação Bienal.
Pendidikan Karakter Anak Usia Dini Berbasis Aqidah Akhlak
Authors: Salsabila Unik Hanifah , Zuhri Muhamad Syaifudin , Rahmandhani Muhamad Arya , Alimi Abdurrahman Wahid
Published: May 2023

Character development must start early. Developing and shaping characters cannot bedone instantly. The primary character education comes from the family and theenvironment before school. The role of educators to direct and guide students is the keypoint. Character education based on aqidah ahlak (moral faith) is also very wellimplemented because Islam has taught what needs to be done to shape a person'scharacter. Islam has provided a lot of teachings in the Al-Qur'an and Hadith regarding howhumans learn and obtain good morals and behavior. This article aims to explain charactereducation for early childhood based on moral faith. By conducting qualitative researchmethod, this article is created by collecting data from books, related journals, ebooks, andpdf. This article contains the concept of moral faith education, the purpose of moral faitheducation, and the scope of moral faith. The concept and purpose of character educationbased on moral faith is the formation of children character. This character is formed in linewith what has been taught in Islam in which the goal is to create children possessing noblemorals.
IMPLEMENTASI PEMBELAJARAN KOOPERATIF MODEL JIGSAW DALAM PEMBELAJARAN ANAK USIA DINI
Authors: Nurfaizah Nurfaizah
Published: May 2023

Pembelajaran kooperatif model jigsaw adalah salah satu dari model pembelajarankooperatif yang bisa diterapkan dalam pembelajaran khususnya dalam pendidikan anakusia dini yang melibatkan siswa untuk belajar bersama dalam kelompok-kelompok keciluntuk mencapai tujuan bersama dalam suatu pembelajaran. Pembelajaran kooperatif tipejigsaw, dicirikan oleh struktur tugas, tujuan dan penghargaan kooperatif, yangmelahirkan sikap ketergantungan yang positif diantara sesama siswa, penerimaanterhadap perbedaan individu dan juga mengembangkan keterampilan bekerjasama dankolaborasi. Tujuan dalam penelitian ini adalah untuk mengetahui macam-macamimplementasi dari pembelajaran kooperatif model jigsaw yang dilakukan padapendidikan anak usia dini. Penelitian ini dikaji dengan metode deskriptif dan pendekatanpenelitian kajian pustaka (library research) sebagai tempat atau sumber acuan. Hasil daripenelian ini menunjukkan adanya keberagaman dalam mengimplementasikanpembelajaran model jigsaw ini diantaranya digunakan untuk matematika anak usia dini,materi untuk kesehatan dan keselamatan anak usia dini, perkembangan kognitif anakusia dini, dan juga untuk minat baca anak usia dini.
Agricultural exports: Systematic literature review on determinants and export-led growth relationship across developing nations
Authors: Kumari Shabnam , Kakar Deepti
Published: May 2023

The present descriptive article intends to systematically review the list of researches that defines the determinants of agricultural exports across various developing nations and also to made an extensive survey of Agri-exports and economic growth association in several countries during the period of 2000 to 2020. This study is descriptive in nature and has used random sampling technique to select the literature on given sample variables. The data has been collected from various sources such as Research Gate, Science Direct, Sage, Springer, Scopus and National Digital library etc. The findings reveal that the variables; production, producer price, domestic price, export price, real exchange rate and real interest rate have a significant positive impact on exports of agricultural commodities from developing nations. The present study reveals that agriculture export development is a prerequisite condition for overall growth of industry and economy while, some researches accumulate mixed or conflicting evidences that there exhibits the lack of conformity on the potential effect of Agri-exports on economy. This meta-survey of literature will illuminate the academician, researchers and scholars to understand the Agri-exports determinants and their relationship with economic growth and so on to government policy makers.
Foreign exchange fluctuations on the performance of agricultural export in Nigeria
Authors: Sylvanus Udoh Francis , Edet Inim Victor , Lynda Ityav, Doofan
Published: May 2023

The study examines the effect of foreign exchange fluctuation on the performance of agricultural export in Nigeria. Despite the emphasis place on foreign exchange, the agricultural export in Nigeria is still not performing well. Time frame was from 1986 to 2021 and the adopted research design was ex post facto, in which the tool of analysis employed was the ARDL, ECM method, co-integration and unit root test as finding revealed that foreign exchange fluctuation on the performance of agricultural volume and value added has negative and insignificant effect in Nigeria. While foreign exchange fluctuation on the performance of agricultural capacity utilization has a positive and significant impact. Giving this finding, recommendations are that Nigerian government should moderate and regulate the rate of exchange activities in order to make certain that it brings about better performance in the agricultural sector. Also, she should strongly attempt to make better the stand of the economy internationally with other nations of the world in order to expand the market for Nigerian agricultural exports. Finally, the government should change the focus of its policy in direction to the external agricultural sector and making sure that it adds in the most favourably way to output performance. As an intentional policy, the government should give support to rural area agriculture by which investors in distinct communities and commodities should be encourage to set up agricultural industries, which will be solely on local raw materials comprising equipment and machines.
Severe Leptospirosis (Weil’s Disease) with Multiple Organ Failure in Urban Setting: A Case Report
Authors: Halim Samuel , Hartono Bryan Arista
Published: May 2023

Leptospirosis is a rare disease that could cause multiple organ failures and death if left untreated. The correct treatment will determine the recovery of patients. A 28-years old male came to the Emergency Department with profuse diarrhea. No prior medical history; worked as a private employee recently assigned to collect rat traps one week before. Laboratories show severe thrombocytopenia, acute liver failure, and acute renal failure support by imaging with the conclusion of hepatomegaly with normal kidney size. During observation in the emergency room, the patient worsens into septic shock. The patient was treated in intensive care, diagnosed with Weil's disease, and treated given antibiotics with aggressive fluid therapy; dialysis was postponed, and close monitoring of the patient's symptoms and organ function. After five days of care, clinical symptoms and organ function improved, and the patient was discharged well. Diagnosis of Leptospirosis is challenging with a combination of signs and symptoms that are not commonly found. Therefore, primary treatment is antibiotic and supportive care such as renal replacement therapy is not routinely needed as long there are improvements in close monitoring. This objective is to increase awareness and treatment option for further severe leptospirosis cases
Genomics education for medical specialists: case-based specialty workshops and blended learning
Authors: Maher Fran , Nisselle Amy , Lynch Elly , Martyn Melissa , Tytherleigh Rigan , Charles Taryn , Gaff Clara
Published: May 2023

Aim: To develop and evaluate genomics education programs for health professionals to expedite the translation of genomics into healthcare. Methods: Our co-design team of genetic specialists, expert medical specialist peers, and genomics educators developed two continuing genomics education programs for health professionals: stand-alone, specialty-specific workshops and a generic blended learning course, combining online learning with workshops. Both programs referenced adult learning theories; workshops included case-based learning and expert peer-led discussion. Longitudinal surveys evaluated changes in confidence and understanding of genomic testing processes and clinical practice. Results: We delivered eleven specialty workshops (414 attendees) and a blended learning course comprising four self-directed online modules (61 users) and workshops (71 attendees) for mixed-specialty groups with adult, pediatric, or oncology cases. Surveys (214 workshops; 63 blended) showed that both programs significantly increased confidence and understanding of genomic testing processes. Blended learning participants showed additional gains in confidence after attending a workshop following online learning. Workshop discussions with experts were valued, particularly regarding interpreting and applying results. At follow-up, gains in confidence and understanding were maintained for both programs and 81% of respondents had performed a new genomics activity in clinical practice. Conclusion: Scalable education is needed. Our results suggest that specialty-specific genomics education may not be required to meet the needs of multiple specialties across a health system. Online learning can meet foundational learning needs but may not be sufficient to apply learning to practice. Blended learning offers flexible, continuing education pathways for dispersed national audiences as genomics becomes increasingly used across varied specialties.
Дослідження мікрохвильових параметрів сигар мокси із полину
Authors: Яненко Олексій Пилипович , Шевченко Костянтин Л. , Головчанський О. М. , Головчанська Олександра Д.
Published: May 2023

В статті наведено результати дослідження мікрохвильових параметрів теплового стану мокса для цзю-терапії. Описана теоретична та фізична основа такого дослідження. Представлена інформація щодо об’єктів дослідження — мокса різного складу та виробників. Наведені характеристики та зроблений опис унікальної радіометричної апаратури і методика проведення дослідження. В результаті експериментальних вимірювань з’ясувалося, що тліючі мокси сигари формують не тільки інфрачервоне, а й мікрохвильове випромінювання. Рівень мікрохвильового сигналу при цьому майже у 100 разів перевищує рівень випромінювання людини, що формує додатковий терапевтичний вплив. Встановлено, що сигари різних фірм і з різним додатковим наповненням мають практично однаковий рівень мікрохвильового випромінювання. Крім того, потужність випромінювання в мм-діапазоні за час досліджень не змінювалася, а потужність інфрачервоного випромінювання, за той же час, зменшилася. Проведені дослідження дозволяють стверджувати про можливий комплексний вплив на пацієнта як теплової, так і мікрохвильової компоненти вихідного сигналу полинної сигари (мокси). Механізм дії всього спектра випромінювання тліючої мокси вимагає більш глибокого вивчення, з точки зору доказової медицини, для використання у лікувальній практиці.
Mechanisation of pre-flowering leaf removal under the temperate climate conditions of Switzerland
Authors: Verdenal Thibaut , Zufferey Vivian , Dienes-Nagy Ágnes , Bourdin Gilles , Spring Jean-Laurent
Published: May 2023

The present trial follows a previous study about pre-flowering leaf removal (LR) (Verdenal et al., 2019) and validates the sustainability of mechanical pre-flowering LR under local Swiss vineyard conditions, using a low-pressure double airflow, to reduce the cost of laborious bunch thinning. In previous studies, pre-flowering LR has shown additional benefits over post-berry-set LR in terms of yield regulation and grape and wine compositions. This trial had two objectives: 1) to test the technical feasibility of mechanical pre-flowering LR, using a low-pressure double airflow and 2) to observe the impact of this practice over five years on yield parameters, grape composition at harvest and wine quality over five years. For this purpose, a trial was conducted on the two cultivars, Doral (white) and Gamay (red), to compare four LR treatments, that is, A) mechanical post-berry-set LR, B) manual pre-flowering LR, C) mechanical pre-flowering LR, and D) double mechanical pre-flowering + post-berry-set LR. More broadly, this work provides practical insights into the consequences of pre-flowering LR on the grapevine, pointing out the advantages and the limits of intensity, timing and mechanisation of this practice. In comparison with the mechanical post-berry-set LR, mechanical pre-flowering LR induced a 7 % loss in bud fruitfulness, a 30 % yield loss and a 3 % gain in total soluble solids (TSS) accumulation in grapes in both cultivars, although the improvement in grape maturity was small and uneven through the years; Gamay anthocyanin concentration remained stable. Pre-flowering LR had no overall impact on the quality of Doral and Gamay wines. Damage was observed on the inflorescences due to the intensity of mechanical pre-flowering LR, which resulted in fewer berries per cluster and a lower yield than with manual LR by the same date. A second LR after berry set was also tested to limit the growth of laterals and clean the clusters from the remaining flower caps to prevent the development of fungal diseases, but it did not show any benefit over a single pre-flowering LR. In conclusion of this trial, a single, moderate mechanical pre-flowering LR is an effective and sustainable practice under temperate climatic conditions, to reduce the costs of laborious manual pre-flowering LR.
Directional Breeding Generates Distinct Genetic Diversity in Hybrid Turf Bermudagrass as Probed with SSR Markers
Authors: Serba Desalegn D. , Fang Tilin , Wu Yanqi
Published: May 2023

Bermudagrass (Cynodon spp.) is one of the drought-resistant warm-season turfgrasses adapted to the southern and transitional zones in the United States. Multiple hybrid varieties have been developed and released for use as a turfgrass and others are in pipeline. Increasing genetic di-versity of commercial varieties is vital to tackle stress tolerance. A DNA profiling study of 21 experimental selections from the Oklahoma State University (OSU) turfgrass breeding program and 11 cultivars was conducted using 51 simple sequence repeat (SSR) primer pairs that spread across the bermudagrass genome. Pairwise genetic relationship analysis among the genotypes using 352 polymorphic bands showed genetic similarity coefficients ranging from 0.59 to 0.89. Cluster analysis using the un-weighted paired group method with arithmetic average (UPGMA) method grouped the entries into six clusters. Correlation analysis identified different levels of pairwise genetic relationship among the entries that largely reflected parental relationship. Di-rectional breeding and selection for cold hardiness or drought resistance created progeny that had distinct genetic diversity in the tested bermudagrasses. It is evident that an increase in genetic diversity of the existing cultivar pool with the release of one or more of the experimental selec-tions for commercial use will strengthen and improve bermudagrass systems.
Respiratory Muscle Function and Submaximal Exercise Performance in Adult Patients With Fontan Circulation
Authors: Ladron-Abia Raquel , Cejudo Pilar , Valverde Israel , Camacho Rocio , Wals-Rodriguez Amadeo Jose , Rodriguez-Puras Maria-Jose , Manso-García Begoña , Gallego Pastora
Published: May 2023

We aimed to provide a comprehensive assessment of exercise physiology of adult Fontan patients (FP) and factors limiting functional capacity (FC). A prospective single-centre study of 37 FP aged ≥16years and 19 healthy-controls (HC), who underwent CPET on cycle-ergometer in February-March 2022. Lung function was impaired in FP, mostly mild restrictive pattern (56.8%). Mean peakVO2 was 21±5.4ml/kg/min, 55% predicted. Morphologically left-single ventricle showed higher peakVO2%predicted (57.4±14.4% vs 43.4±8.1%, p=0.045). A lower peakVO2%predicted was observed in patients with an early flattened and/or descending O2 pulse at maximal exertion (52±14% vs 62±12.5, p=0.04 and 47.6±9% vs 60±14 respectively, p=0.018) and chronotropic insufficiency (53±12% vs 69.8±20%, p=0.008). Strong positive correlation was observed between %OUES and peakVO2%predicted (r=0.726, p>0.001). PeakVO2%predicted was progressively higher as the level of physical activity increased (low-level 49.5±14%, moderate-level 55±12%, intense-level 69±20%). FP showed lower inspiratory muscle strength compared to HC but it was no statistically associated with either peakVO2 or VE/VCO2 slope. In FP OUES is a useful submaximal parameter in those who fail to reach maximal exertion. Chronotropic insufficiency and early flattened or descending oxygen pulse slope were factors associated with low peakVO2. Regular intense physical activity improves FC. Although FP have inspiratory muscle weakness, its impact on FC is unclear.
Balancing Strategy for Battery Systems Based on Reconfigurable Converters
Authors: Wan Guangwei , Zhang Qiang , Li Menghan , Li Siyuan , Fu Zehao , Liu Junjie
Published: May 2023

This paper proposes a new battery balancing control strategy based on state of charge (SOC) for addressing the problem of cell-to-cell differences in lithium-ion battery systems. The strategy utilizes a reconfigurable converter system to transfer energy from high-SOC battery modules to low-SOC battery modules and allows balancing the battery modules while they are powering the load. A MATLAB/Simulink simulation model with five batteries was built to validate the effectiveness of the proposed balancing strategy under unloaded and loaded conditions. The simulation results demonstrate that the proposed strategy achieves more efficient and accurate battery module balancing compared to the previous balancing modes, thus increasing the overall lifespan and safety of the battery pack.
Emerging Pathogen Threats in Transfusion Medicine and the Role of Pathogen Reduction Technologies
Authors: Cardoso Marcia , Ragan Izabela , Hartson Lindsay , Goodrich Raymond P
Published: May 2023

Emerging infectious disease threats are becoming more frequent due to various social, political and geographical pressures including increased human-animal contact, global trade, transportation and changing climate conditions. As a result, the threat that emerging agents can be spread by blood contact or transfusion of blood products also becomes increasingly problematic. Blood transfusion is essential in treating patients with anemia, blood loss, and other medical conditions. However, these lifesaving components can become a vector for spreading diseases, particularly to vulnerable populations. New methods have been implemented on a global basis for prevention of transfusion transmission via plasma, platelet, and whole blood products. Implementing proactive pathogen reduction methods can significantly reduce the likelihood of disease transmission via blood transfusion, even for newly emerging agents whose transmissibility and susceptibility are still being evaluated as they emerge. In this review, we consider the Mirasol PRT system for blood safety which is based on a photochemical method involving Riboflavin and UV light. We provide examples of how emerging threats such as Ebola, SARS-CoV-2, Hepatitis E, monkeypox and other agents have been evaluated in real time regarding effectiveness of this method for reducing the likelihood of disease transmission via transfusion. Keywords: transfusion; blood; pathogen reduction; emerging infectious diseases.
The Central Role of the Kynurenine Pathway of Tryptophan Metabolism in the Pathophysiology of Frailty, Sarcopenia and Osteoporosis
Authors: Ballesteros Juan , Rivas Daniel , Duque Gustavo
Published: May 2023

Tryptophan is an essential nutrient required to produce niacin (vitamin B3), which is needed for energy metabolism and DNA production. Alterations in tryptophan metabolism could have significant effects on aging and musculoskeletal health. The kynurenine pathway, the main catabolic route of tryptophan, is modulated by inflammatory factors, which are increased in older persons, a process known as inflammaging. Osteoporosis, sarcopenia, osteosarcopenia and frailty have also been linked with chronic increased levels of inflammatory factors. Due to the disruption of the kynurenine pathway by chronic inflammation and/or changes in the gut microbiota, serum levels of toxic kynurenines are increased and have been associated with osteoporosis, sarcopenia and frailty. In contrast, anabolic end products of this pathway, such as picolinic acid, have demonstrated a beneficial effect on bone and muscle. In addition, recent studies have shown that physical activity can modulate this pathway by promoting the secretion of anabolic kynurenines. According to the evidence collected, kynurenines could have a promising role as biomarkers for osteoporosis sarcopenia, osteosarcopenia and frailty in older persons. In addition, some of these metabolites could become important targets for developing new pharmacological treatments for these conditions.
T lymphocyte-derived IFN- facilitates breast cancer cells to pass the blood-brain barrier: an in vitro study corroborating translational data.
Authors: Pedrosa Rute M.S.M. , Kros Johan M. , Schrijver Benjamin , Berrevoets Cor , Marques Rute B. , Van Eijck Casper C.H.J. , Debets Reno , Leenen Pieter J.M. , Dik Willem A. , Mustafa Dana A.M.
Published: May 2023

The appearance of brain metastasis is the most serious complication of breast cancer with mostly fatal outcomes. To reach the brain, tumor cells need to pass the blood-brain barrier (BBB). The molecular mechanisms underlying penetration of the BBB are largely unknown. Previously we found that tumor-infiltrating T lymphocytes enhance the development of brain metastasis of estrogen receptor-negative (ER-) breast cancer. In the current study, we investigate the contribution of T lymphocytes and the IFN- pathway in enabling breast cancer cells to pass the in vitro BBB. CD8+ cells display the strongest stimulatory effect on breast cancer cell passage. We show that inhibition of the IFN- receptor in MDA-MB-231 breast cancer cells, or neutralization of soluble IFN-, impairs the in vitro trespassing of breast cancer cells. Importantly, we validated our findings using gene expression data of breast cancer patients. CXCL-9,-10,-11/CXCR3 axis, dependent on IFN- signaling activity, was overexpressed in primary breast cancer samples of patients who developed brain metastasis. The data support a role for T-lymphocytes and the IFN- pathway in the formation of brain metastasis of ER- breast cancer, and offer targets to design future therapies for preventing breast cancer cells to cross the BBB.
Oral Pathology in the Elderly: Prevalence in a Hub Hospital
Authors: Frizzerin Carla , Alberton Giulia , Rushiti Armina , Bacci Christian
Published: May 2023

The elderly present age-related morphological and histological changes of the oral cavity; Literature displays many studies regarding the specific pathologies of the oral cavity in elderly patients, but no etiologically based classification is available. The aim of this study was to analyze the series of patients over 65 who were treated by our Unit of Pathology between 2020 and 2022 for a suspicion of oral lesion or for preventive dental evaluation (in anticipation of cardiac surgery, anti-resorptive drugs intake, chemotherapy, radiotherapy of the head-neck district or transplantation). The analysis was conducted by dividing oral lesions into 5 groups depending on the etiology: reactive, immunological, traumatic, benign and malignant degenerative. The sixth group consisted of patients undergoing preventive dental evaluation. The study included 435 patients; 91 of them were diagnosed with a reactive origin pathology, 174 with immunological origin pathology, 48 with traumatic pathology and 86 with degenerative pathology (42 benign and 44 malignant). 36 patients went to our Unit for preventive specialist evaluation. Oral health has a major impact on the daily life of the elderly; The examination of oral mucosa in geriatric patients is a fundamental diagnostic moment to report lesions early, thus allowing easier prevention and treatment.
Design of Intelligent Nonlinear H2/H∞ Robust Control Strategy of Diesel Generator Based CPSOGSA Optimization Algorithm
Authors: Zou Yidong , Xiao Boyi , Qian Jing , Xiao Zhihuai
Published: May 2023

In today's human society, diesel generators (DGs) are highly applied into the human energy and electricity supply system due to its technical, operational and economic advantages. This paper proposes an intelligent nonlinear $H_2/H_{\infty}$ robust controller based on the chaos particle swarm gravity search optimization algorithm (CPSOGSA), which controls the speed and excitation of a DG. In this method, firstly, establish the nonlinear mathematical model of the DG and then design the nonlinear $H_2/H_{\infty}$ robust controller based on this. The direct feedback linearization and the $H_2/H_{\infty}$ robust control theory are combined and applied. Based on the design of the integrated controller for DG speed and excitation, the system's performance requirements are transformed into a standard robust $H_2/H_{\infty}$ control problem. The parameters of the proposed solution controller are optimized by using the proposed CPSOGSA. The introduction of CPSOGSA completes the design of an intelligent nonlinear $H_2/H_{\infty}$ robust controller for DG. The simulation is implemented in MATLAB/Simulink, and the results are compared with the PID control method. The obtained results prove that the proposed method can effectively improve the dynamic accuracy of the system and the ability to suppress disturbances and improve the stability of the system.
Implementation of a Vascular Access Specialist Team in a Tertiary Hospital: A Cost-Benefit Analysis
Authors: Ricou Ríos Laura , Esposito Català Candela , Pons Calsapeu Arnau , Adroher Mas Cristina , Andrés Martínez Isabel , Nuño Ruiz Isaac , Castellà Creus Mònica , Castellà Fàbregas Laia , García Quesada Maria José , Estrada Cuxart Oriol , Ara del Rey Jordi , López Seguó Francesc
Published: May 2023

Background: The use of peripherally inserted central catheters and midline catheters is growing due to their potential benefits. These devices can increase patient safety and satisfaction while reducing the use of resources. As a result, many hospitals are establishing vascular access specialist teams staffed by nurses who are trained in the insertion and maintenance of these catheters. Objective: Evaluate ex-ante whether the benefits of replacing peripheral venous catheters, peripherally inserted central catheters and midline catheters with ultrasound-guided peripherally inserted central catheters and midline catheters by a vascular access specialist team outweigh their costs. Methods: Cost-benefit analysis from the perspective of the healthcare provider based on administrative data. The study estimates the reduction in resources used when replacing peripherally inserted central catheters, midline catheters and peripheral venous catheters with ultrasound-guided peripherally inserted central catheters and midlines, as well as the additional resources required for their use. Results: Each ultrasound-guided peripherally inserted central catheter replacing a peripherally inserted central catheter, results in a measurable resource reduction of approximately €31. When 3 peripheral venous catheters are replaced by an ultrasound-guided peripherally inserted central catheter, the saving is €63. Similarly, each ultrasound-guided midline catheter replacing a midline, results in a reduction of €16, while each ultrasound-guided midline catheter replacing 3 peripheral venous catheters results in a reduction of €96. Conclusion: The benefits of replacing peripheral venous catheters, peripherally inserted central catheters and midline catheters by introducing a vascular access specialist team trained in the implantation of ultrasound-guided peripherally inserted central catheters and midline catheters, outweigh its cost mainly because of the decrease in hospital stay due to the lowered risk of healthcare-associated infections. These results motivate the implementation of the service, adding to previous experience suggesting that it is also preferable from the point of view of patient safety and satisfaction.
Drug Regulatory-compliant Validation of a qPCR Assay for Bioanalysis Studies of a Cell Therapy Product – With a Special Focus on Matrix Interferences in a Wide Range of Organ Tissues
Authors: Schröder Hannes M. , Niebergall-Roth Elke , Norrick Alexandra , Esterlechner Jasmina , Ganss Christoph , Frank Markus H. , Kluth Mark A.
Published: May 2023

Quantitative polymerase chain reaction (qPCR) has emerged as an important bioanalytical method for assessing the pharmacokinetics of human cell-based medicinal products after xenotransplantation into immunodeficient mice. A particular challenge in bioanalytical qPCR studies is that the different tissues of the host organism can affect amplification efficiency and amplicon detection to varying degrees, and ignoring these matrix effects can easily cause a significant underestimation of the true number of target cells in a sample. Here we describe the development and drug regulatory-compliant validation of a TaqMan® qPCR assay for quantification of mesenchymal stromal cells in the range of 125 to 20,000 cells/200 µl lysate by amplification of a human-specific, highly repetitive αsatellite DNA sequence of the chromosome 17 centromere region HSSATA17. Assessment of matrix effects in 14 different mouse tissues and blood revealed a wide range of spike recovery rates across the different tissue types from 11 to 174%. Based on these observations, we propose to perform systematic spike-and-recovery experiments during assay validation and to correct for the effects of the different tissue matrices on cell quantification in subsequent bioanalytical studies by multiplying the back-calculated cell number by tissue-specific factors derived from the inverse of the validated percent recovery rate.
Photoelectrochemical Deposition of Silicon–Carbon Layer on P-Type Semiconductors and Aluminum–Copper Alloy in Ionic Liquid
Authors: Grigucevičienė Asta , Kalinauskas Putinas , Staišiūnas Laurynas , Leinartas Konstantinas , Selskis Algirdas , Juzeliūnas Eimutis
Published: May 2023

Electrochemical deposition of silicon at room temperature is problematic due to intrinsically low conductivity of the deposits. This study reports the photoelectrochemical (PEC) deposition of silicon (Si) and silicon–carbon (Si–C) layers from an ionic liquid at temperature 40 oC using silicon tetrachloride (SiCl4) as a silicon precursor. Amorphous layers are deposited on p-type silicon (p-Si), p-type gallium arsenide (p-GaAs), and aluminum–copper alloy AA2024. The semi-conductor substrates are activated by white LED illumination, which generated photoelectrons, thereby making the substrate conductive with respect to the cathodic reaction. Photoresponsive-ness of the deposits is proven by the light-induced photocurrents on an optically inactive substrate made of the alloy AA 2024. The proposed method paves the way for the electrochemical modifica-tion of semiconductors and metals with Si and Si–C structures, which are applicable in various fields, such as; batteries, anti-corrosion coatings, photovoltaics, or PEC electrodes for hydrogen production.
Neuroendocrine Effects on the Risk of Metabolic Syndrome in Children
Authors: Scorrano Giovanna , La Bella Saverio , Matricardi Sara , Chiarelli Francesco , Giannini Cosimo
Published: May 2023

Endocrine and nervous systems reciprocally interact to manage physiological individual functions and homeostasis. The nervous system modulates hormone release through the hypothalamus, the main cerebrally specialized structure of the neuroendocrine system. Indeed, it is involved in various metabolic processes, administering hormone and neuropeptide release at different levels. This complex activity is affected by neurons of various cerebral areas, environmental factors, peripheral organs, and mediators through feedback mechanisms. Therefore, neuroendocrine pathways have a key role in metabolic homeostasis control, and their abnormalities have been associated with the development of Metabolic Syndrome (MetS) in children. The impaired functioning of genes, hormones, and neuropeptides of various neuroendocrine pathways involved in several metabolic processes has been related to an increased risk of dyslipidaemia, visceral obesity, insulin resistance, type 2 diabetes mellitus, and hypertension. This review examines the neuroendocrine effects on the risk of MetS in children, identifying and underlying the several conditions associated with neuroendocrine pathway disruption. Neuroendocrine systems should be considered in the complex pathophysiology of MetS, and, when genetic or epigenetic mutations in "hot" pathways occur, they could be studied for new potential target therapies in severe and drug-resistant paediatric forms of MetS.
Inhaled Corticosteroids and the Risk of Nontuberculous Mycobacterial Pulmonary Disease in Chronic Obstructive Pulmonary Disease: Findings from a Nationwide Population-Based Study
Authors: Yu Iseul , Hong Se Hwa , Chang Min-Seok , Lee Seok Jeong , Yong Suk Joong , Lee Won-Yeon , Kim Sang-Ha , Lee Ji-Ho
Published: May 2023

Studies have shown increased nontuberculous mycobacterial pulmonary disease (NTM) incidence with inhaled corticosteroid (ICS) use in patients with chronic respiratory diseases; however, this association in chronic obstructive pulmonary disease (COPD) remains insufficiently studied. Using a nationwide population-based database of the Korean National Health Insurance Service, newly diagnosed COPD patients (20052018) treated with inhaled bronchodilators were selected. An NTM case was defined by the presence of the first diagnostic code following inhaled bronchodilator use. Results indicated that ICS users did not have an increased risk of NTM disease compared to non-ICS users (hazard ratio [HR], 1.121; 95% confidence interval [CI], 0.9501.323; p = 0.1755). The highest quartile of the cumulative ICS dose was associated with the development of NTM (1.200, 0.9501.323, p = 0.0497). Medium (1.229, 1.0081.499, p = 0.0410) and high daily doses of ICS (1.637, 1.2412.160, p = 0.0005) were associated with an increased risk of NTM disease. There was no difference in the risk of NTM according to ICS type. ICS use may not increase the risk of developing NTM disease in patients with COPD. However, physicians should weigh the potential benefits and risks of ICS, especially when using high doses and prolonged durations.
A Comparative Analysis of Sampling Methods for Aquatic Macroinvertebrates
Authors: Orozco González Christopher E
Published: May 2023

Aquatic macroinvertebrates play a crucial role in freshwater ecosystems, serving as reliable indicators of water quality and ecosystem health. To effectively monitor and assess these ecosystems, it is essential to employ appropriate sampling methods that capture the diversity and abundance of macroinvertebrate communities. The objective of this study was to provide a comprehensive overview and comparative analysis of different sampling methods for aquatic macroinvertebrates, highlighting their advantages, limitations, and applicability in ecological research was carried out. The results showed that the most commonly used methods include Kick-net Sampling, Surber Sampler, D-frame Net, Bottle Sampling, and Pitfall Traps. Researchers should select methods based on study goals, environmental conditions, and target organisms. Integrating multiple techniques enhances understanding of macroinvertebrate communities and their responses to environmental changes, contributing to improved assessments of water quality, ecosystem health, and conservation in freshwater ecosystems.
Does Iodine Intake Play a Role in Modifying the Relationship between Maternal Dysglycemia and Birth Weight?
Authors: Ovadia Yaniv S. , Gefel Dov , Toledano Yoel , Rosen Shani , Avrahami-Benyounes Yael , Groisman Ludmila , Rorman Efrat , Hen Lihi , Fytlovich Shlomo , Katz Liora S , Anteby Eyal Y , Shenhav Simon
Published: May 2023

It is unclear how maternal glycemic status and maternal iodine status influence birth weight in mild-to-moderate iodine deficiency (ID). We studied the association between birth weight and both maternal glucose levels and iodine intake in pregnant women with mild-to-moderate ID. Glucose values were assessed using a glucose challenge test (GCT), non-fasting glucose before delivery; iodine status was assessed using an iodine food frequency questionnaire, serum thyroglobulin (Tg) and urinary iodine concentrations (UIC). Thyroid antibodies and free thyroxine (FT4) were measured. Obstetric and an-thropometric data were also collected. Large for gestational age (LGA) was predicted using a Cox proportional hazards model with multiple confounders. Tg>13g/L was in-dependently associated with LGA (adjusted hazard ratio = 3.4, 95% CI: 1.4–10.2, p=0.001). Estimated iodine intake correlated with FT4 among participants reporting io-dine-containing supplements (ICS) after adjusting for confounders (β = 0.4 95 %CI: 0.0002-0.0008, p=0.001). Newborn weight percentiles were inversely correlated with maternal FT4 values (β=-0.2 95 %CI:-0.08 - -56.49, p=0.049). We conclude that in mild-to-moderate ID regions, maternal insufficient iodine status may increase LGA risk. Iodine status and ICS intake may modify the effect maternal dysglycemia has on offspring weight.
Identification and Molecular Characterization of a Novel Large-Scale Variant (Exons 4_18 Loss) in the LDLR Gene as a Cause of Familial Hypercholesterolaemia in an Italian Family
Authors: Concolino Paola , De Paolis Elisa , Moffa Simona , Onori Maria Elisabetta , Soldovieri Laura , Ricciardi Tenore Claudio , De Bonis Maria , Rabacchi Claudio , Santonocito Concetta , Rinelli Martina , Calandra Sebastiano , Giaccari Andrea , Urbani Andrea , Minucci Angelo
Published: May 2023

Next Generation Sequencing (NGS), now widely used in the clinical setting, offers an efficient and comprehensive molecular approach for patients with Familial hypercholesterolemia (FH). Although the dominant form of disease is mostly due to low-density lipoprotein receptor (LDLR) small-scale pathogenic variants, approximately 10% of molecularly defined FH cases are due to Copy Number Variations (CNVs). Here, we report a novel large deletion of the LDLR gene involving exons 4–18, identified by bioinformatic analysis of NGS data in an Italian family. A long PCR strategy was employed for breakpoint region analysis where an insertion of 6 nucleotides (TTCACT) was found. Two Alu sequences, identified within intron 3 and exon 18, could underlie the identified rearrangement by a Nonallelic Homologous Recombination (NAHR) mechanism. NGS proves to be a powerful tool used to precisely identify CNVs, in addition to small-scale variants in FH-related genes. At this purpose, the use and implementation of this cost-effective, efficient molecular approach meets the clinical need for personalized diagnosis in FH cases.
Knowledge Sharing among Students in Social Media: The Mediating Role of Family and Technology Supports in the Academic Development Nexus in an Emerging Country
Authors: Haque Md. Armanul , Zhang Xiaojuan , Akanda A.K.M Eamin Ali , Hasan Md Nazmul , Islam Md Mahbubul , Saha Amitav , Hossain Md Ikbal , Rahman Zihadur
Published: May 2023

Social networking opened up new avenues for learning and knowledge sharing. Due to its document exchange, virtual communication, and knowledge production capabilities, social media is a helpful tool for learning and teaching. The research embraces multiple goals. First, this study examines Bangladeshi university students' social value, communication and collaboration, trust, and perceived benefits of knowledge sharing through social media in academic advancement. The second goal is to examine how families and technology support mediates those aspects of social media knowledge sharing with student academic development. We used Technology Acceptance Model and Social Exchange Theory as examples of how social media sharing of knowledge impacts academic progress in Bangladeshi university students through family and technological support. PLS-SEM was used using survey data from 737 Bangladeshi students to test the model. Social value, communication and collaboration, trust, and perceived benefits of sharing knowledge through social media significantly enhance Bangladeshi students' academic growth. In the case of mediation, family and technological support mediates the relationship between communication and collaboration, trust, perceived benefits and academic development. However, there is no mediation with the social value of knowledge sharing in social media with student’s academic development. The article concludes with implications, limitations, and future research.
Area-Selective (Inhibited) Atomic Layer Deposition of ZnO on Si/SiO2 Using Tris(trimethylamino)methylsilane
Authors: Moeini Behnam , Avval Tahereh , Brongersma Hidde , Průša Stanislav , Bábík Pavel , Vaníčková Elena , Strohmeier Brian R , Bell David S , Eggett Dennis , George Steven M , Linford Matthew R
Published: May 2023

Delayed atomic layer deposition (ALD) of ZnO, i.e., area selective (AS)-ALD, was successfully achieved on silicon wafers (Si/SiO2) terminated with tris(dimethylamino)methylsilane (TDMAMS). This resist molecule was deposited in a home-built, near atmospheric pressure, flow-through , gas-phase reactor. TDMAMS has been shown to react with Si/SiO2 in a single cycle/reaction and to drastically reduce the number of silanols that remain at the surface. ZnO was deposited in a commercial ALD system using dimethylzinc (DMZ) as the zinc precursor and H2O as the coreactant. Deposition of TDMAMS was confirmed by spectroscopic ellipsometry (SE), X-ray photoelectron spectroscopy (XPS), and wetting. ALD of ZnO, including its selectivity on TDMAMS – terminated Si/SiO2 (Si/SiO2/TDMAMS), was confirmed by in situ ellipsometry, ex situ SE, XPS, and/or high sensitivity – low energy ion scattering (HS-LEIS). The thermal stability of the TDMAMS resist layer, which is an important parameter for AS-ALD, was investigated by heating Si/SiO2/TDMAMS in air and nitrogen at 330 ºC. ALD of ZnO takes place more readily on Si/SiO2/TDMAMS heated in the air than in N2, suggesting greater damage to the surface heated in the air. To better understand the in situ ALD of ZnO, the data were also plotted as the normalized growth per cycle and to show the selectivity. Even one, short pulse of TDMAMS effectively passivates Si/SiO2. TDMAMS can be an effective small molecule inhibitor of ALD of ZnO on Si/SiO2 surfaces.