bluuebunny/crossref_metadata_2025 huggingface dataset:
TANGGAPAN NARAPIDANA LEMBAGA PEMASYARAKATAN KOTA MADIUN PADA SANKSI HUKUM PIDANA ISLAM TERHADAP SIKAP TAUBATAN NASHUHA
Authors: Muhayati Siti , Anggriana Tyas Martika , Nugroho Imam Setyo , Setiawan Aris Indra , Islamiati Ikhda Putri Nur
Published: March 2018

Tiap hari masyarakat Indonesia disuguhi berita tentang tindak pidana
pelanggaran Hak Syar’i Manusia (Hak Asasi Manusia), terutama pembunuhan,
pencurian, perampokan dan pelakunya sebagaian besar warga negara Indonesia
sendiri. Padahal warga negara Indonesia sebagain besar beriman Islam dan
dibawah naungan falsaah Pancasila. Idealnya warga negara Indonesia selain taat
pada ulil amri juga taat pada Allah sehingga warga negara Indonesia akan menjadi
manusia yang mampu bersikap untuk mengakui, menghormati dan melindungi
hak hidup dan hak memiliki harta orang lain. Tapi dalam kenyataannya warga
negara Indonesia masih ada yang melakukan tindak kejahatan dan tidak jera walau
pelakunya telah diberi sanksi pidana, bahkan yang belum pernah melakukan
tindak kejahatan menambah jumlah pelaku tindak pidana.
Penelitian ini bertujuan untuk mengetahui hubungan antara tanggapan
narapidana Lembaga Pemasyarakatan Kota Madiun pada sanksi hukum pidana
Islam dengan sikap taubatan nashuha. Metode penelitian yang digunakan adalah
Ex-post-facto. Populasi dalam penelitian ini adalah narapidana pelanggar Hak
Syar’i Manusia (Hak Asasi manusia) sebanyak 17 orang. Angket penelitian
disebarkan kepada subjek penelitian, yaitu narapidana pencurian dan perampokan
di Lembaga Pemasyarakatan Kota Madiun. Subjek penelitian dipilih secara
purposive, yaitu dengan cara memilih subjek berdasarkan pada putusan hukum
pidana yang dijatuhkan oleh Majelis Hakim.
Berdasarkan analisis data dengan menggunakan analisis Spearman diketahui
bahwa terdapat hubungan antara tanggapan narapidana Lembaga Pemasyarakatan
Kota Madiun pada sanksi hukum pidana Islam dengan sikap taubatan nashuha.
Kegiatan pembinaan mental yang dilakukan di Lembaga Pemasyarakatan Klas 1
Kota Madiun melalui kegiatan keagamaan, yaitu berupa pengajian, baca Alqur’an,
baca Yasin dan Tahlil dapat membantu narapidana untuk mengembangkan
tanggapan yang positif terhadap sanksi hukuman yang dijatuhkan kepadanya,
sehingga narapidana terdorong untuk memiliki sikap taubatan nashuha.
Narapidana merasa jera dan mampu mengembangkan suatu perasaan, keyakinan
dan perbuatan untuk berpindah dari perbuatan buruk ke perbuatan baik yang terus
menerus dan istiqomah. Jika hal ini dapat dilakukan secara istiqomah oleh
narapidana, maka setelah dinyatakan bebas, individu yang bersangkutan akan
mampu menjalani kehidupan bermasyarakat yang sehat dan terhindar dari tindak
kriminal di kemudian hari.
PELATIHAN KECAKAPAN VOKASIONAL UNTUK MENINGKATKAN KEMANDIRIAN SOSIAL EKONOMI INDIVIDU EKS PSIKOTIK DI UPT REHABILITASI SOSIAL EKS PSIKOTIK PROVINSI JAWA TIMUR
Authors: Chotim Muh. , Christiana Ratih , Pratama Andika Hady
Published: March 2018

Ex-psychotic individuals encounter many difficulties in the process of socializing and
returned to the environment, so that the necessary training skills before returning to the
family and society. The purpose of this study was (1) To determine the effort to improve
the social and economic independence of individual ex-psychotic through vocational
skills training in the Social Rehabilitation Unit Ex Psychotic Social Service of East Java
Province, (2) To determine the effectiveness of vocational skills training to improve social
and economic independence of the individual ex-psychotic The Social Rehabilitation Unit
Ex Psychotic Social Service of East Java Province.Writing method using a case study
approach to field studies (field research) combined with literature (library research).
This community service is a descriptive research, data analysis using qualitative analysis
with interactive model. The analyzed data is the data rate of socio-economic
independence of individuals before and after the psychotic ex vocational skills
training.This research with two activities that make the carpet of material raffia rope and
wooden crafts. Potential outcomes include training in order to improve their socioeconomic
independence, product copyrighted works, a national scientific journals and
strengthening the role of counselors and social services functions.
PENGARUH BIMBINGAN KELOMPOK DENGAN TEKNIK ROLE PLAY TERHADAP KECENDERUNGAN PERILAKU AGRESIF SISWA KELAS VIII-E SMP NEGERI 1 BARAT KABUPATEN MAGETAN
Authors: Suntari Eria , Triningtyas Diana Ariswanti
Published: March 2018

Tujuan penelitian ini adalah untuk mengetahui pengaruh bimbingan kelompok dengan teknik role play terhadap kecenderungan perilaku agresif siswa kelas VIII E SMP Negeri 1 Barat Kabupaten Magetan.

Penelitian ini dilakukan dengan menggunakan metode eksperimen dengan desain One-Group Pretest-Posttest Design. Bentuk eksperimen yang dilakukan dalam penelitian ini adalah dengan menyampaikan bimbingan kelompok dengan teknik role play untuk mengatasi perilaku agresif pada siswa kelas VIII-E SMP Negeri 1 Barat Kabupaten Magetan. Populasi dalam penelitian ini adalah siswa kelas VIII-E SMP Negeri 1 Barat Kabupaten Magetan yang terindikasi memiliki tingkat kecenderungan perilaku agresif yang tinggi dengan jumlah 34 siswa. Sampel penelitian ini adalah 30% dari siswa kelas VIII-E SMP Negeri 1 Kabupaten Magetan yang memiliki kecenderungan perilaku agresif yang tinggi. Teknik pengambilan sampel dalam penelitian ini adalah teknik purposive sampling. Data yang digunakan dalam penelitian ini dikumpulkan dengan menggunakan teknik angket yang disusun sendiri oleh peneliti. Analisis data dalam penelitian ini menggunakan uji t-score.

Berdasarkan hasil analisis data penelitian, diperoleh hasil sebagai berikut: harga t-hitung (t-score) sebesar 6,885. Untuk mengetahui apakah harga t-hitung sebesar 6,885 tersebut signifikan atau tidak signifikan, maka perlu dikonsultasikan dengan harga t-tabel. Harga t-tabel untuk N = 10 dan derajad bebas (d.b) = 1 pada taraf signifikansi sebesar 5%, diperoleh bilangan 2,228. Dengan demikian maka harga t-hitung lebih besar dibandingkan dengan harga t-tabel (signifikan/TS=5%). Simpulan penelitian ini adalah bimbingan kelompok dengan teknik role play dapat mengurangi kecenderungan perilaku agresif siswa kelas VIII E SMP Negeri 1 Barat Kabupaten Magetan.

 
Kata Kunci:    Bimbingan Kelompok, Teknik Role Play, kecenderungan Perilaku Agresif.
STRATEGI MENGAJARKAN NILAI FAIR PLAY PADA PELATIH SEPAKBOLA DI KOTA MADIUN
Authors: Muryanto Hagus
Published: March 2018

Tidak semua pelatih sepakbola memiliki pemahaman yang memadai tentang fair play, apalagi sampai mengajarkan nilai fair play pada para pemain sepakbola yang dilatihnya. Atas dasar itulah maka dilakukan penelitian dengan tujuan untuk memberikan beberapa cara yang tepat dalam mengajarkan nilai fair play kepada para pelatih sepak bola khususnya yang ada di kota madiun.

Metode penelitian menggunakan penelitian eksperimen, lokasi penelitian dilakukan di kota Madiun melibatkan seluruh klub yang ada di kota Madiun, sampel penelitian adalah para pelatih sepakbola, instrument penelitian menggunakan angket, analisis data menggunakan kuantitatif (uji t) dan kualitatif (interactive model).

Hasil penelitian menunjukkan bahwa setelah dilakukan pemberian pelatihan fair play sebanyak 16 kali pertemuan yang diawali dengan pembahasan, penghayatan, praktik dan refleksi maka diperoleh suatu hasil bahwa strategi tersebut berhasil dengan efektif, hasil uji t menunjukkan pada pre test dan post test dengan hasil uji Independent sample t test adalah  P-Value lebih kecil dari α = 0,04 < 0,05 sedangkan hasil analisis interactive model menunjukkkan bahwa strategi dengan model fair play HIA berjalan efektif.
Simpulan dari hasil penelitian menunjukkan strategi pengajaran nilai fair play dapat digunakan sebagai strategi dalam mengajarkan fair play.
Paradoxical intervention dalam bimbingan dan konseling untuk mengatasi kecemasan
Authors: Maba Aprezo Pardodi
Published: March 2018

Abstrak

Kecemasan adalah perasaan tidak menentu yang membuat seseorang merasa takut dan khawatir. Kecemasan pada tingkat tertentu mampu membuat seseorang menjadi lebih produktif, sebaliknya, kecemasan berlebihan dapat merusak. Salah satu upaya yang dapat dilakukan untuk mengurangi kecemasan adalah pemberian layanan bimbingan dan konseling, terutama menggunakan paradoxical intervention yang telah terbukti efektif untuk mengatasi gangguan kecemasan. Melalui artikel ini penulis mencoba menyajikan satu teknik intervensi unik yang bisa menjadi alternatif  bagi guru bimbingan dan konseling atau konselor untuk membantu konseli mengatasi kecemasan dan meningkatkan keefektifan layanan bimbingan dan konseling.

Kata Kunci : Kecemasan, Bimbingan dan Konseling, Paradoxical Intervention.

 

Abstract

Anxiety is an uncertain feeling that makes someone fear and worry. Anxiety in a certain level able to makes someone more productive, in opposite, excessive anxiety can be obstructive. An effort that can utilize to reduce anxiety is guidance and counseling, particularly, paradoxical intervention which evidence-based shown highly effective to overcome the anxiety disorder. Through this article author is trying to present an unique intervention technique which can be an alternative for guidance and counseling teacher or counselor in order to help counselee coping with anxiety and promoting the effectiveness of guidance and counseling service.
Keywords : Anxiety, Guidance and Counseling, Paradoxical Intervention.
Joseph Beuys, la estética hoy, un compromiso político
Authors: Benavides Juan Francisco
Published: March 2018

Joseph Beuys es uno de los más influyentes artistas en el mundo contemporáneo, sus ideas y propuestas aún no han sido comprendidas del todo y muchas de ellas resultan transgresoras hasta hoy en día, en especial su declaración de que “todo el mundo es artista”. Beuys no sólo se enfrenta al quehacer artístico, comprende que el arte es algo mucho más profundo y complejo, es una energía que mueve al mundo y que, como muchas de las energías en el pensamiento occidental, es incomprendido y valorizado sólo desde su apariencia y superficialidad.

Palabras clave: Estética, conceptualismo, arte contemporáneo, apariencia, transgresión.
Neo-Dada y Accionismo: La conexión Nueva York – Viena de la Neo-vanguardia
Authors: Mangia Guerrero Eugenio
Published: March 2018

Este ensayo es una continuación de un estudio previo sobre el rol desempeñado por la Neo-vanguardia de los años sesentas en adelante.  En este caso particular, el enfoque es más sobre el papel de las artistas femeninas pioneras del Arte Corporal y su legado actual. La investigación busca auscultar los orígenes del fenómeno artístico desde un punto de vista multidisciplinario para poder matizar la complejidad detrás de estas expresiones del arte contemporáneo. Se propone, además, hallar las relaciones conceptuales, intelectuales y sociales entre las neo-vanguardias de Europa y Estados Unidos de Norte América; para poder impartir una dimensión más personal entre estas expresiones de nuevo cuño estético.

Palabras clave: Origen, Performance, Arquetipo, Feminismo, Arte Corporal.
Registro y difusión del performance atístico en la era digital
Authors: Avila Santiago
Published: March 2018

El siguiente texto tiene como objetivo indagar en la relación entre performance y nuevas tecnologías, haciendo énfasis en su registro y difusión. Primero se pondrá en contexto el momento en el que surge la era digital y su influencia en las artes visuales y específicamente en el performance. Luego, a partir de la obra de las artistas: Orlan y Amalia Ulman, se evidenciarán distintas metodologías para abordar el registro de performance, dando especial atención a elementos como: el ciberespacio, la simultaneidad de la acción a través de la pantalla y el uso del cuerpo virtual, entre otros. Finalmente se reflexionará acerca de lo que supone para el performance y su registro, enfrentarse a un publico que no puede entender la  realidad,  sin la mediación de dispositivos tecnológicos.

Palabras clave: Performance, Era Digital, Tecnología, Registro.
Big Data: Concept, Potentialities and Vulnerabilities
Authors: Almeida Fernando
Published: March 2018

The evolution of information systems and the growth in the use of the Internet and social networks has caused an explosion in the amount of available data relevant to the activities of the companies. Therefore, the treatment of these available data is vital to support operational, tactical and strategic decisions. This paper aims to present the concept of big data and the main technologies that support the analysis of large data volumes. The potential of big data is explored considering nine sectors of activity, such as financial, retail, healthcare, transports, agriculture, energy, manufacturing, public, and media and entertainment. In addition, the main current opportunities, vulnerabilities and privacy challenges of big data are discussed. It was possible to conclude that despite the potential for using the big data to grow in the previously identified areas, there are still some challenges that need to be considered and mitigated, namely the privacy of information, the existence of qualified human resources to work with Big Data and the promotion of a data-driven organizational culture.
Polisakarida Krestin dari Jamur Coriolus versicolor terhadap hitung Jenis Leukosit Mencit yang diinfeksi Mycobacterium tuberculosis
Authors: Purnamasari Risa
Published: March 2018

Penelitian ini bertujuan untuk mengetahui peran polisakarida krestin (PSK) dengan waktu pemberian yang berbeda terhadap hitung jenis leukosit mencit yang diinfeksi Mycobacterium tuberculosis. Penelitian ini menggunakan 30 ekor mencit betina dewasa jenis Mus musculus strain BALB/C, berumur 8-10 minggu, berat badan berkisar 25-30 g. Polisakarida krestin (PSK) diisolasi dari Coriolus versicolor yang diperoleh dari alam. Infeksi menggunakan Mycobacterium tuberculosis strain H37Rv (ATCC 27294 T). Hewan percobaan dikelompokkan menjadi 6 kelompok sebagai berikut: kelompok I, hanya diberi akuades; kelompok II, hanya pemberian PSK; kelompok III, hanya dengan infeksi Mycobacterium tuberculosis; kelompok IV, pemberian PSK sebelum infeksi Mycobacterium tuberculosis; kelompok V, pemberian PSK sesudah infeksi Mycobacterium tuberculosis; kelompok VI, pemberian PSK sebelum dan sesudah infeksi Mycobacterium tuberculosis. Pemberian PSK dilakukan selama 7 hari berturut-turut melalui gavage. Infeksi Mycobacterium tuberculosis dilakukan sebanyak 2 kali dengan selang waktu 1 minggu melalui intraperitoneal. Hitung jenis leukosit dilakukan dengan mengelompokan masing-masing jenis leukosit dalam 100 sel leukosit pada apusan darah, dan data hasil pengamatan dianalisis dengan uji Kruskal-Wallis, kemudian untuk mengetahui signifikansi dilanjutkan dengan uji Mann-Whitney. Secara keseluruhan penelitian menunjukkan presentase jenis leukosit dengan jumlah tertinggi adalah neutrofil. Pada kelompok VI presentase monosit dan neutrofil meningkat melebihi normal, sedangkan presentase limfosit menurun, dan presentase basofil dan eosinofil tidak mengalami perubahan. Kesimpulan penelitian ini adalah PSK meningkatkan jumlah leuksosit mencit jenis neutrofil dan monosit pada waktu sebelum dan sesudah infeksi Mycobacterium tuberculosis
Analysis of the Relationship between Types of Rebuttal, Interaction Patterns and Informal Statistical Inference in the Students' Discussion on Comparing the Data of Two Groups
Authors:   The Korea Society Of Educational Studies In Mathematics, Seo Min-Ju , Yoo YunJoo
Published: March 2018

Informal statistical inference occurring in group interaction for statistical tasks is closely related to the process of informal argumentation. Among many activities in the group discussion, rebuttal is one of the significant elements of argumentation. This study conducted experiments regarding group discussion activities using tasks comparing two data sets and the analyzing of students discourse. We subsequently coded the conversations to identify discourse move, classified each statement according to types of the rebuttal, and measured the students' level of statistical inference. We therefore observed that the rebuttal against thesis mainly appeared in responsive interactions, and the rebuttal against ground appeared in elaborative interactions stimulating the statistical inference of the participants. We noted that the level of statistical inference even got lower in the discussion containing responsive interaction including only the rebuttal against thesis. On the other hand, in the discussion containing elaborative interaction accompanied by the rebuttal against ground, even errors in the arguments were identified and corrected improved as well as the improvement in the level of statistical inference.
A New Electronic Voting Protocol Using Secret Sharing Based on Set of Path Domination
Authors: F. Ibraheem Samaa
Published: March 2018

For secret electronic voting protocol we always need a secure system. Secret sharing scheme are proved to be safe guarding through distributing the input key to number of participants then reconstructing the shares through a secure process. In this paper, the set of dominating paths in special graph is used to share the votes among a set of candidates, such that, each candidate represents an edge in the graph. Based on this new technique, we have shown that it is secure and confidential. The efficiency of the new protocol is demonstrated in terms of time and cost.
Construção de conteúdos digitais interativos a partir da Teoria das Inteligências Múltiplas de Gardner
Authors: Santos Raquel Alves
Published: March 2018

Este artigo apresenta dados de pesquisa aplicada desenvolvida no âmbito do Grupo de Pesquisa Cultura Digital e Educação. Teve como objetivo investigar pressupostos teóricos conceituais para a criação de um modelo conceitual que fundamentou a produção do protótipo de material didático hipermídia. O modelo foi consubstanciado na Teoria das Inteligências Múltiplas (TIM) de Howard Gardner com aplicação interativa para TVDI e potencial para ativar as cinco mentes que serão necessárias aos gestores do futuro. Como resultado, foram produzidos dois materiais: um caderno didático e uma videoaula interativa, a ser utilizados na formação de gestores por meio da educação a distância (EAD). Os resultados finais comprovaram os pressupostos levantados, demonstrando que as aplicações interativas produzidas podem possibilitar aos gestores acionarem suas múltiplas inteligências e buscarem diferentes caminhos para a aprendizagem. A validação do modelo permitiu verificar que a interatividade proporcionada pelo material pode conduzir o aprendente a desenvolver potencialidades para acionar as mentes mais valorizadas no futuro.
Tecnologias digitais e ensino: o ensino de informática auxiliando no processo de ensino/aprendizagem
Authors: Sousa Antonio Iderlian Pereira de
Published: March 2018

A informática tem apresentado um processo evolutivo crescente desde seu surgimento até o presente momento. A escola pública brasileira recebeu vários incentivos e formas de implantação de cursos de informática nos últimos anos. No entanto, detectou-se a falta de conhecimento e treinamento para professores para ensinar e lidar com as questões dessa ordem nas escolas e muitos laboratórios de informática permanecem sem uso. Diante do quadro, optou-se pelo oferecimento de um curso de informática e foi muito bem aceito. O curso foi ministrado em uma escola pública, aos sábados, durante quatro meses por um aluno do curso de Geografia da UFGD. O resultado foi positivo. O acesso ao conhecimento da informática é dever do estado, todavia na sua falta, ações de voluntariado continuam sempre bem-vindas.
Olhares de Norbert Elias: inclusão escolar do aluno surdo
Authors: Rizzo Jakellinny Gonçalves de Souza
Published: March 2018

O presente trabalho objetiva relacionar as teorias de Norbert Elias estudadas durante as aulas da disciplina Educação, Diversidade e Identidade do Programa de Pós-Graduação em Educação (PPGEdu) - Mestrado da Universidade Federal da Grande Dourados (UFGD) com a vivência dos alunos surdos em escolas comuns. Elias fala sobre a balança de poder, figuração interdependências entre as pessoas, que estão sempre em movimento, figurando as pessoas como estabelecidas em certos momentos, já em outro como outsiders. Os alunos surdos nas escolas comuns inúmeras vezes se encontram como outsiders por conta de sua língua, porém não permanecem nessa figuração se estiverem em uma escola direcionada para a educação de surdos como o INES.
A 15 year old girl presented with rectal bleeding, growth failure, digital clubbing and mental retardation
Authors: Yasmin Afsana , Rukunuzzaman Md. , Karim A. S. M. Bazlul , Rashid Rafia , Benzamin Md. , Dey Bishnu Pada
Published: March 2018

This article has no abstract. The first 100 words appear below:A 15 year old girl of non-com-sanguineous parents presented at the out-patient department with the history of intermittent rectal bleeding for the last 6 years. Rectal bleeding was painless and there was the passage of a small amount of bright red blood drop by drop after defecation. She also complained of something coming out through the anus during defecation for last one year. Mother also noticed that her child had learning difficulties and not growing well like other peers. Her menarche had not started yet. Her elder two sisters and younger two brothers are healthy. She had no family history of rectal bleeding or colorectal cancer.
Biosynthesis of Rishirilide B
Authors: Schwarzer Philipp , Wunsch-Palasis Julia , Bechthold Andreas , Paululat Thomas
Published: March 2018

Rishirilide B was isolated from Streptomyces rishiriensis and Streptomyces bottropensis on the basis of its inhibitory activity towards alpha-2-macroglobulin. The biosynthesis of rishirilide B was investigated by feeding experiments with different 13C labelled precursors using the heterologous host Streptomyces albus J1074::cos4 containing a cosmid encoding of the gene cluster responsible for rishirilide B production. NMR spectroscopic analysis of labelled compounds demonstrate that the tricyclic backbone of rishirilide B is a polyketide synthesized from nine acetate units. One of the acetate units is decarboxylated to give a methyl group. The origin of the starter unit was determined to be isobutyrate.
Power Control Optimization of an Underwater Piezoelectric Energy Harvester
Authors: Aramendia Iñigo , Fernandez-Gamiz Unai , Zulueta Guerrero Ekaitz , Lopez-Guede Jose , Sancho Javier
Published: March 2018

Over the past few years, it has been established that vibration energy harvesters with intentionally designed components can be used for frequency bandwidth enhancement under excitation for sufficiently high vibration amplitudes. Pipelines are often necessary means of transporting important resources such as water, gas, and oil. A self-powered wireless sensor network could be a sustainable alternative for in-pipe monitoring applications. A new control algorithm has been developed and implemented into an underwater energy harvester. Firstly, a computational study of a piezoelectric energy harvester for underwater applications has been studied for using the kinetic energy of water flow at four different Reynolds numbers Re = 3000, 6000, 9000, and 12,000. The device consists of a piezoelectric beam assembled to an oscillating cylinder inside the water of pipes from 2 to 5 inches in diameter. Therefore, unsteady simulations have been performed to study the dynamic forces under different water speeds. Secondly, a new control law strategy based on the computational results has been developed to extract as much energy as possible from the energy harvester. The results show that the harvester can efficiently extract the power from the kinetic energy of the fluid. The maximum power output is 996.25 µW and corresponds to the case with Re = 12,000.
Bloch Surface Waves Using Graphene Layers: An Approach toward In-Plane Photodetectors
Authors: Dubey Richa , Marchena Miriam , Vosoughi Lahijani Babak , Kim Myun-Sik , Pruneri Valerio , Herzig Hans
Published: March 2018

A dielectric multilayer platform was investigated as a foundation for two-dimensional optics. In this paper, we present, to the best of our knowledge, the first experimental demonstration of absorption of Bloch surface waves in the presence of graphene layers. Graphene is initially grown on a Cu foil via Chemical Vapor Deposition and transferred layer by layer by a wet-transfer method using poly(methyl methacrylate), (PMMA). We exploit total internal reflection configuration and multi-heterodyne scanning near-field optical microscopy as a far-field coupling method and near-field characterization tool, respectively. The absorption is quantified in terms of propagation lengths of Bloch surface waves. A significant drop in the propagation length of the BSWs is observed in the presence of graphene layers. The propagation length of BSWs in bare multilayer is reduced to 17 times shorter in presence of graphene monolayer, and 23 times shorter for graphene bilayer.
Exergy Analysis of Serpentine Thermosyphon Solar Water Heater
Authors: Hasan Muhammad , Mahadi Md. , Miyazaki Takahiko , Koyama Shigeru , Thu Kyaw
Published: March 2018

The performance of a solar hot water system is assessed for heat pump and domestic heating applications. Thermodynamic analysis on a serpentine-type thermosyphon flat-plate solar heater is conducted using the Second Law of thermodynamics. Exergetic optimization is first performed to determine the parameters for the maximum exergy efficiency using MATLAB optimization toolbox. Geometric parameters (collector surface area, dimensions, and pipe diameter), optical parameters (transmittance absorptance product), ambient temperature, solar irradiation and operating parameters (mass flow rate, fluid temperature, and overall heat transfer (loss) coefficient) are accounted for in the optimization scheme. The exergy efficiency at optimum condition is found to be 3.72%. The results are validated using experimental data and found to be in good agreement. The analysis is further extended to the influence of various operating parameters on the exergetic efficiency. It is observed that optical and thermal exergy losses contribute almost 20%, whereas approximately 77% exergy destruction is contributed by the thermal energy conversion. Exergy destruction due to pressure drop is found negligible. The result of this analysis can be used for designing and optimization of domestic heat pump system and hot water application.
Role of Akt Isoforms Controlling Cancer Stem Cell Survival, Phenotype and Self-Renewal
Authors: Rivas Sergio , Gómez-Oro Carla , Antón Inés , Wandosell Francisco
Published: March 2018

The cancer stem cell (CSC) hypothesis suggests that tumours are maintained by a subpopulation of cells with stem cell properties. Although the existence of CSCs was initially described in human leukaemia, less evidence exists for CSCs in solid tumours. Recently, a CD133+ cell subpopulation was isolated from human brain tumours exhibiting stem cell properties in vitro as well as the capacity to initiate tumours in vivo. In the present work, we try to summarize the data showing that some elements of the Phosphoinositide 3-kinase Class I (PI3K)/ Thymoma viral oncogene protein kinase (Akt) pathway, such the activity of PI3K Class I or Akt2, are necessary to maintain the CSC-like phenotype as well as survival of CSCs (also denoted as tumour-initiating cells (TICs)). Our data and other laboratory data permit a working hypothesis in which each Akt isoform plays an important and specific role in CSC/TIC growth, self-renewal, maintaining survival, and epithelial-mesenchymal transition (EMT) phenotype, not only in breast cancer, but also in glioma. We suggest that a more complete understanding is needed of the possible roles of isoforms in human tumours (iso-signalling determination). Thus, a comprehensive analysis of how hierarchical signalling is assembled during oncogenesis, how cancer landmarks are interconnected to favour CSC and tumour growth, and how some protein isoforms play a specific role in CSCs to ensure that survival and proliferation must be done in order to propose/generate new therapeutic approaches (alone or in combination with existing ones) to use against cancer.
Tannic Acid Induces Endoplasmic Reticulum Stress-Mediated Apoptosis in Prostate Cancer
Authors: Nagesh Prashanth , Hatami Elham , Chowdhury Pallabita , Kashyap Vivek , Khan Sheema , Hafeez Bilal , Chauhan Subhash , Jaggi Meena , Yallapu Murali
Published: March 2018

Endoplasmic reticulum (ER) stress is an intriguing target with significant clinical importance in chemotherapy. Interference with ER functions can lead to the accumulation of unfolded proteins, as detected by transmembrane sensors that instigate the unfolded protein response (UPR). Therefore, controlling induced UPR via ER stress with natural compounds could be a novel therapeutic strategy for the management of prostate cancer. Tannic acid (a naturally occurring polyphenol) was used to examine the ER stress mediated UPR pathway in prostate cancer cells. Tannic acid treatment inhibited the growth, clonogenic, invasive, and migratory potential of prostate cancer cells. Tannic acid demonstrated activation of ER stress response (Protein kinase R-like endoplasmic reticulum kinase (PERK) and inositol requiring enzyme 1 (IRE1)) and altered its regulatory proteins (ATF4, Bip, and PDI) expression. Tannic acid treatment affirmed upregulation of apoptosis-associated markers (Bak, Bim, cleaved caspase 3, and cleaved PARP), while downregulation of pro-survival proteins (Bcl-2 and Bcl-xL). Tannic acid exhibited elevated G1 population, due to increase in p18INK4C and p21WAF1/CIP1 expression, while cyclin D1 expression was inhibited. Reduction of MMP2 and MMP9, and reinstated E-cadherin signifies the anti-metastatic potential of this compound. Altogether, these results demonstrate that tannic acid can promote apoptosis via the ER stress mediated UPR pathway, indicating a potential candidate for cancer treatment.
Influence of Cu Content on the Structure, Mechanical, Friction and Wear Properties of VCN–Cu Films
Authors: Wu Fanjing , Yu Lihua , Ju Hongbo , Xu Junhua , Shi Ji
Published: March 2018

VCN–Cu films with different Cu contents were deposited by reactive magnetron sputtering technique. The films were evaluated in terms of their microstructure, elemental composition, mechanical, and tribological properties by X-ray diffraction (XRD), energy-dispersive X-ray spectroscopy (EDS), high resolution transmission electron microscopy (HR-TEM), Raman spectrometry, nano-indentation, field emission scanning electron microscope (FE-SEM), Bruker three-dimensional (3D) profiler, and high-temperature ball on disc tribo-meter. The results showed that face-centered cubic (fcc) VCN, hexagonal close-packed (hcp) V2CN, fcc-Cu, amorphous graphite and CNx phases co-existed in VCN–Cu films. After doping with 0.6 at.% Cu, the hardness reached a maximum value of ~32 GPa. At room temperature (RT), the friction coefficient and wear rate increased with increasing Cu content. In the temperature range of 100–500 °C, the friction coefficient decreased, but the wear rate increased with the increase of Cu content.
Response-Based Sampling for Binary Choice Models With Sample Selection
Authors: Arezzo Maria Felice , Guagnano Giuseppina
Published: March 2018

Sample selection models attempt to correct for non-randomly selected data in a two-model hierarchy where, on the first level, a binary selection equation determines whether a particular observation will be available for the second level (outcome equation). If the non-random selection mechanism induced by the selection equation is ignored, the coefficient estimates in the outcome equation may be severely biased. When the selection mechanism leads to many censored observations, few data are available for the estimation of the outcome equation parameters, giving rise to computational difficulties. In this context, the main reference is Greene (2008) who extends the results obtained by Manski and Lerman (1977), and develops an estimator which requires the knowledge of the true proportion of occurrences in the outcome equation. We develop a method that exploits the advantages of response-based sampling schemes in the context of binary response models with a sample selection, relaxing this assumption. Estimation is based on a weighted version of Heckman’s likelihood, where the weights take into account the sampling design. In a simulation study, we found that, for the outcome equation, the results obtained with our estimator are comparable to Greene’s in terms of mean square error. Moreover, in a real data application, it is preferable in terms of the percentage of correct predictions.
Comparison of Workload for University Core Courses Taught in Regular Semester and Time-Compressed Term Formats
Authors: Lutes Lyndell , Davies Randall
Published: March 2018

This study compared student workload and perceived value of coursework assigned for a matching set of semester and term general education courses at Brigham Young University. Statistically significant differences in workloads were found between most semester and term courses. While term workloads were slightly lighter in general, both could be called “university lite,” in that students did not spend the expected two hours outside of class per hour in class. Math and physics courses came closest to meeting the expected workloads, which tended to remain constant between semesters and terms. Differences in the value students reported for homework varied significantly by the autonomy of the instructor to adapt his own course section. Some of the curricular differences between sessions might be attributed to efficiencies instructors incorporated for shorter sessions without affecting overall course quality. Typically, reading- and writing-intensive courses showed the most negative impact when offered in a term format. The findings from this study suggest that, while some subjects lend themselves well to a compressed-time format, not all courses are suited to being taught in this way.
Comparative Analysis of Si- and GaN-Based Single-Phase Transformer-Less PV Grid-Tied Inverter
Authors: Alatawi Khaled , Almasoudi Fahad , Manandhar Mahesh , Matin Mohammad
Published: March 2018

Recently, the interest in grid-tied PV transformer-less inverters has increased rapidly, because of their higher efficiency and lower cost compared to traditional line transformer inverters. This paper presents a new modified transformer-less topology derived from H5 inverter, and provides a detailed comparison between the use of GaN and Si devices for the proposed topology. Detailed operation modes, inverter structure and switching strategy of the proposed topology are presented. Datasheet information, conduction losses, switching losses, and heat sink requirements are studied and analyzed to provide an accurate comparison between GaN and Si power devices for the proposed topology operating at unity power factor. The results show that, GaN power devices significantly reduce the power losses in the system, which consequently allow a significant increase in either inverter power rating or switching frequency. Thus, the use of GaN power devices for the proposed inverter can be more appealing and cost-effective approach.
Adaptable Energy Systems Integration by Modular, Standardized and Scalable System Architectures: Necessities and Prospects of Any Time Transition
Authors: Hinker Jonas , Wohlfahrt Thomas , Drewing Emily , Contreras Paredes Sergio , Mayorga González Daniel , Myrzik Johanna
Published: March 2018

Energy conversion and distribution of heat and electricity is characterized by long planning horizons, investment periods and depreciation times, and it is thus difficult to plan and tell the technology that optimally fits for decades. Uncertainties include future energy prices, applicable subsidies, regulation, and even the evolution of market designs. To achieve higher adaptability to arbitrary transition paths, a technical concept based on integrated energy systems is envisioned and described. The problem of intermediate steps of evolution is tackled by introducing a novel paradigm in urban infrastructure design. It builds on standardization, modularization and economies of scale for underlying conversion units. Building on conceptual arguments for such a platform, it is then argued how actors like (among others) municipalities and district heating system operators can use this as a practical starting point for a manageable and smooth transition towards more environmental friendly supply technologies, and to commit to their own pace of transition (bearable investment/risk). Merits are not only supported by technical arguments but also by strategical and societal prospects like technology neutrality and availability of real options.
Phenotype- and SSR-Based Estimates of Genetic Variation between and within Two Important Elymus Species in Western and Northern China
Authors: Zhang Zongyu , Xie Wengang , Zhang Junchao , Zhao Xuhong , Zhao Yongqiang , Wang Yanrong
Published: March 2018

Elymus nutans and Elymus sibiricus are two important perennial forage grasses of the genus Elymus, widely distributed in high altitude regions of Western and Northern China, especially on the Qinghai-Tibetan Plateau. Information on phenotypic and genetic diversity is limited, but necessary for Elymus germplasm collection, conservation, and utilization. In the present study, the phenotypic and genetic differentiation of 73 accessions of the two species were evaluated using 15 phenotypic traits and 40 expressed sequence tag derived simple sequence repeat markers (EST-SSRs). The results showed that only 7.23% phenotypic differentiation (Pst) existed between the two Elymus species based on fifteen quantitative traits. Principal component analysis (PCA) revealed that leaf traits, spike traits, and some seed traits were dominant factors in phenotypic variation. Moreover, 396 (97.8%) and 331 (87.1%) polymorphic bands were generated from 40 EST-SSR primers, suggesting high levels of genetic diversity for the two species. The highest genetic diversity was found in the Northeastern Qinghai-Tibetan Plateau groups. Clustering analysis based on molecular data showed that most accessions of each Elymus species tended to group together. Similar results were described by principal coordinates analysis (PCoA) and structure analysis. The molecular variance analysis (AMOVA) revealed that 81.47% and 89.32% variation existed within the geographical groups for the two species, respectively. Pearson’s correlation analyses showed a strong positive correlation between Nei’s genetic diversity and annual mean temperature. These results could facilitate Elymus germplasm collection, conservation, and future breeding.
Transcriptome Profiling Reveals the EanI/R Quorum Sensing Regulon in Pantoea Ananatis LMG 2665T
Authors: Sibanda Siphathele , Kwenda Stanford , Tanui Collins , Shyntum Divine , Coutinho Teresa , Moleleki Lucy
Published: March 2018

Pantoea ananatis LMG 2665T synthesizes and utilizes acyl homoserine lactones (AHLs) for signalling. The complete set of genes regulated by the EanI/R quorum sensing (QS) system in this strain is still not fully known. In this study, RNA-sequencing (RNA-seq) was used to identify the EanI/R regulon in LMG 2665T. Pairwise comparisons of LMG 2665T in the absence of AHLs (Optical density (OD)600 = 0.2) and in the presence of AHLs (OD600 = 0.5) were performed. Additionally, pairwise comparisons of LMG 2665T and its QS mutant at OD600 = 0.5 were undertaken. In total, 608 genes were differentially expressed between LMG 2665T at OD600 = 0.5 versus the same strain at OD600 = 0.2 and 701 genes were differentially expressed between LMG 2665T versus its QS mutant at OD600 = 0.5. A total of 196 genes were commonly differentially expressed between the two approaches. These constituted approximately 4.5% of the whole transcriptome under the experimental conditions used in this study. The RNA-seq data was validated by reverse transcriptase quantitative polymerase chain reaction (RT-qPCR). Genes found to be regulated by EanI/R QS were those coding for redox sensing, metabolism, flagella formation, flagella dependent motility, cell adhesion, biofilm formation, regulators, transport, chemotaxis, methyl accepting proteins, membrane proteins, cell wall synthesis, stress response and a large number of hypothetical proteins. The results of this study give insight into the genes that are regulated by the EanI/R system in LMG 2665T. Functional characterization of the QS regulated genes in LMG 2665T could assist in the formulation of control strategies for this plant pathogen.
A Neutrophil Proteomic Signature in Surgical Trauma Wounds
Authors: Bekeschus Sander , Lackmann Jan-Wilm , Gümbel Denis , Napp Matthias , Schmidt Anke , Wende Kristian
Published: March 2018

Non-healing wounds continue to be a clinical challenge for patients and medical staff. These wounds have a heterogeneous etiology, including diabetes and surgical trauma wounds. It is therefore important to decipher molecular signatures that reflect the macroscopic process of wound healing. To this end, we collected wound sponge dressings routinely used in vacuum assisted therapy after surgical trauma to generate wound-derived protein profiles via global mass spectrometry. We confidently identified 311 proteins in exudates. Among them were expected targets belonging to the immunoglobulin superfamily, complement, and skin-derived proteins, such as keratins. Next to several S100 proteins, chaperones, heat shock proteins, and immune modulators, the exudates presented a number of redox proteins as well as a discrete neutrophil proteomic signature, including for example cathepsin G, elastase, myeloperoxidase, CD66c, and lipocalin 2. We mapped over 200 post-translational modifications (PTMs; cysteine/methionine oxidation, tyrosine nitration, cysteine trioxidation) to the proteomic profile, for example, in peroxiredoxin 1. Investigating manually collected exudates, we confirmed presence of neutrophils and their products, such as microparticles and fragments containing myeloperoxidase and DNA. These data confirmed known and identified less known wound proteins and their PTMs, which may serve as resource for future studies on human wound healing.
Unravelling the Effects of the Mutation m.3571insC/MT-ND1 on Respiratory Complexes Structural Organization
Authors: Iommarini Luisa , Ghelli Anna , Tropeano Concetta , Kurelac Ivana , Leone Giulia , Vidoni Sara , Lombes Anne , Zeviani Massimo , Gasparre Giuseppe , Porcelli Anna
Published: March 2018

Mammalian respiratory complex I (CI) biogenesis requires both nuclear and mitochondria-encoded proteins and is mostly organized in respiratory supercomplexes. Among the CI proteins encoded by the mitochondrial DNA, NADH-ubiquinone oxidoreductase chain 1 (ND1) is a core subunit, evolutionary conserved from bacteria to mammals. Recently, ND1 has been recognized as a pivotal subunit in maintaining the structural and functional interaction among the hydrophilic and hydrophobic CI arms. A critical role of human ND1 both in CI biogenesis and in the dynamic organization of supercomplexes has been depicted, although the proof of concept is still missing and the critical amount of ND1 protein necessary for a proper assembly of both CI and supercomplexes is not defined. By exploiting a unique model in which human ND1 is allotopically re-expressed in cells lacking the endogenous protein, we demonstrated that the lack of this protein induces a stall in the multi-step process of CI biogenesis, as well as the alteration of supramolecular organization of respiratory complexes. We also defined a mutation threshold for the m.3571insC truncative mutation in mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 1 (MT-ND1), below which CI and its supramolecular organization is recovered, strengthening the notion that a certain amount of human ND1 is required for CI and supercomplexes biogenesis.
Facial Nerve Paralysis after Onyx Embolization of a Jugular Paraganglioma: A Case Report with a Long-Term Follow Up
Authors: Odat Haitham , Alawneh Khaled , Al-Qudah Mohannad
Published: March 2018

Jugular paragangliomas are slow growing highly vascular tumors arising from jugular paraganglia. The gold standard of treatment is complete surgical resection. Pre-operative embolization of these highly vascular tumors is essential to reduce intra-operative bleeding, allow safe dissection, and decrease operative time and post-operative complications. Onyx (ethylene-vinyl alcohol copolymer) has been widely used as permanent occluding material for vascular tumors of skull base because of its unique physical properties. We present the case of a 33-year-old woman who had left-sided facial nerve paralysis after Onyx embolization of jugular paraganglioma. The tumor was resected on the next day of embolization. The patient was followed up for 30 months with serial imaging studies and facial nerve assessment. The facial verve function improved from House–Brackmann grade V to grade II at the last visit.
Flying the RNA Nest: Drosophila Reveals Novel Insights into the Transcriptome Dynamics of Early Development
Authors: Lefebvre Fabio , Lécuyer Éric
Published: March 2018

Early development is punctuated by a series of pervasive and fast paced transitions. These events reshape a differentiated oocyte into a totipotent embryo and allow it to gradually mount a genetic program of its own, thereby framing a new organism. Specifically, developmental transitions that ensure the maternal to embryonic control of developmental events entail a deep remodeling of transcriptional and transcriptomic landscapes. Drosophila provides an elegant and genetically tractable system to investigate these conserved changes at a dazzling developmental pace. Here, we review recent studies applying emerging technologies such as ribosome profiling, in situ Hi-C chromatin probing and live embryo RNA imaging to investigate the transcriptional dynamics at play during Drosophila embryogenesis. In light of this new literature, we revisit the main models of zygotic genome activation (ZGA). We also review the contributions played by zygotic transcription in shaping embryogenesis and explore emerging concepts of processes such as transcriptional bursting and transcriptional memory.
Electrospun Composite Liquid Crystal Elastomer Fibers
Authors: Sharma Anshul , Lagerwall Jan
Published: March 2018

We present a robust method to prepare thin oriented nematic liquid crystalline elastomer-polymer (LCE-polymer) core-sheath fibers. An electrospinning setup is utilized to spin a single solution of photo-crosslinkable low molecular weight reactive mesogens and a support polymer to form the coaxial LCE-polymer fibers, where the support polymer forms the sheath via in situ phase separation as the solvent evaporates. We discuss the effect of phase separation and compare two different sheath polymers (polyvinylpyrrolidone and polylactic acid), investigating optical and morphological properties of obtained fibers, as well as the shape changes upon heating. The current fibers show only irreversible contraction, the relaxation most likely being hindered by the presence of the passive sheath polymer, increasing in stiffness on cooling. If the sheath polymer can be removed while keeping the LCE core intact, we expect LCE fibers produced in this way to have potential to be used as actuators, for instance in soft robotics and responsive textiles.