bluuebunny/crossref_metadata_2025 huggingface dataset:
The clinical significance of immunological markers of diffuse toxic goiter
Authors: Sviridenko N. Yu. , Kryukova I. V. , Keda Yu. M. , Mkrtumova N. A. , Kraynova S. I. , Biryukova M. P. , Kandror V. I.
Published: September 2019

The clinical significance of measuring thyroid antibodies has been evaluated. With this aim in view, 47 patients with diffuse toxic goiter (DTG) (46 women and 1 man) aged 15 to 65 were examined. Antibodies to TTH receptors were detected in 85 patients with decompensated DTG by the radioligand method based on assessment of blocking of TTH binding to its receptor in the presence of patient’s serum. Antibodies to thyroglobulin (TG) were detected in 55.6% patients before therapy. Blood level of TG was increased in 42% of patients. Antibodies to the microsomal fraction (MS) were detected in 59% of patients. The activity of antibodies to TTH receptor depended on the disease severity, degree of the thyroid enlargement, and size of goiter. The incidence of antibodies to TG and their titers did not depend on the severity of thyrotoxicosis or size of goiter. The incidence of antibodies to MS increased only with enlargement of goiter. The incidence and titers of antibodies gradually decreased in the course of mercasolyl therapy of DTG. After 6 months antibodies to TTH receptors were found in 57% of patients, their activity being decreased, too. The incidence of anti-MS antibodies dropped to 45%, whereas the rate of detection of antibodies to TG was virtually the same. One year after therapy antibodies to TTH receptors were found in 29.4%> of patients. The rate of detection of antibodies to TG and MS decreased to 25 and 20%o, respectively. Hence, a high rate of detection of antireceptor antibodies in DTG and the relationship between the thyroid status and the titer of these antibodies confirm their leading role in the pathogenesis of the disease. The presence of antibodies to TG and MS in no more than half of the patients with DTG and absence of a clear-cut correlations between these antibodies and various clinical hormonal parameters of the disease indicates their significance solely as markers of the autoimmune process in the thyroid but does not specify the nature of its involvement. Antibodies to TTH receptors are the most informative immunological test for the diagnosis of DTG and the markers of immunological remission of the disease.
Some gastroenterological aspects of endocrinology (lecture)
Authors: Kalinin A. P.
Published: September 2019

According to special, but not always complete reports and relevant studies, one in ten adult residents of Russia suffers from a particular digestive system disease (P. Grigoryev // Med. Newspaper. - 1996. - April 24). Their timely identification was facilitated by the widespread introduction of endoscopic studies into clinical practice using standardized methods for evaluating the results. At the same time, endoscopic examinations are still often carried out without necessarily obtaining a biopsy for subsequent histological and, more importantly, immunohistochemical studies. The latter allows you to more objectively judge the etiological causes of the disease, among which endocrine occupy a special place.
The use of the HELPER device for determining infrared radiation of the skin in the diagnosis of diabetic angiopathies
Authors: Zhuk E. A.
Published: September 2019

A HELPER device is offered for the early diagnosis and monitoring of patients with diabetic angiopathies. The device picks up the limb skin temperature gradient. The temperature gradient in the diabetics increases with the progress of diabetic angiopathies in comparison with normal subjects.
Evaluation of the effectiveness of chronocorrection of hemocoagulation and microcirculation by angioprotectors and antiplatelet agents of diabetic microangiopathy
Authors: Tulemisov E. U. , Zaslavskaya R. M. , Smirnova L. V.
Published: September 2019

The efficacies of four protocols for treating patients with insulin-dependent diabetes mellitus (IDDM) and microangiopathies of the I and II degree are compared: traditional therapy with pro dectin (250 mg) and trental (100 mg) 3 times daily (17 patients), prodectin (250 mg) and aspirin (125 mg) 3 times a day (16 patients), chronotherapy with prodectin in a dose of 250 mg and trental in a dose of 100 mg once a day (17 patients), and prodectin (250 mg) and aspirin (125 mg) once a day 1.5-2 h before the acrophase of the circadian rhythm of blood coagulation, microcirculation, and peripheral hemodynamics parameters (16 patients). Before and 15-17 days after treatment, blood coagulation values were studied by the autocoagulation and hemolysate aggregation tests, measurements of blood fibrinogen, antithrombin III, soluble fibrin monomer complexes, and fibrinolytic activity of the blood; microcirculation was assessed by biomicroscopy of the eye conjunctiva, and peripheral hemodynamics by the radioactive xenome method and rheova- sography of the shin. The studies demonstrated a higher efficacy of chronotherapy in comparison with traditional prodectin in combination with trental and aspirin.
Clinical and epidemiological characteristics of diabetic nephropathy in children and adolescents in Moscow with insulin-dependent diabetes mellitus
Authors: Sivous G. I. , Kasatkina E. P. , Sokolovskaya V. N. , Samsonova L. N. , Gerasimova N. P. , Voichik E. A. , Alekseeva T. M. , Gvindzhiliya T. V.
Published: September 2019

A total of 166 patients (72 males and 94 females) with insulindependent diabetes mellitus (IDDM) aged 5 to 21 years with disease duration of 1 to 18 years were examined in order to assess the clinical picture and epidemiology of diabetic nephropathy (DN) in children and adolescents in Moscow. Microalbuminuria (MAU)*was the criterion of DN. DN was diagnosed in 75 (45.7%) of patients: in 64 (85.3%) at the MAU stage and in 11 (14.6%)) at the stage of proteinuria. There were no cases with the nephrotic syndrome or chronic renal insufficiency. The minimal duration of IDDM in adolescents with MAU was about 2 years, in those with proteinuria about 5 years. All patients with DN were pubertal or postpubertal. The incidence of DN did not depend on the sex, age, or pubertal status. DN risk factors in these patients were chronic hyperglycemia, total and prepubertal duration of diabetes, hereditary predisposition to arterial hypertension, and lipid disorders. Therefore, prepubertal children with disease duration of 5 years and adolescents with disease duration of 1 year since IDDM manifestation are to be screened for DN.
Morphological analysis of changes in the heart and aorta of rats undergoing bilateral ovariectomy; cardio- and vasoprotective effects of estradiol
Authors: Karachentsev A. N. , Melchenko I. A.
Published: September 2019

The effect of bilateral oophorectomy on the structure of the heart and aorta and changes in their structure during substitution estradiol therapy were assessed in rats. Estrogen deficit led to development of nonspecific changes in myocardial and aortic microstructure with tissue edema. Substitute estradiol therapy protected the oophorectomized animals from stress-dependent morphological changes of the cardiovascular system.
Adrenal incidentoma
Authors: Vetshev P. S. , Ippolitov L. I. , Sinatulina V. A.
Published: September 2019

Accidentally detected adrenal tumors, or the so-called incidentalomas or adrenalomas (from incidentally discovered adrenal mass), are a relatively new and insufficiently studied problem of endocrinology and endocrine surgery [18, 25, 43, 48, 56].

Issues related to the etiology, morphogenesis, diagnosis and tactics of treatment with incidental have been little studied and are not consolidated into a single integrated system. Several years ago in the periodical press there were few works devoted to this problem [18, 48], and the corresponding sections in the special manuals were extremely short or absent. For many years, hormone-inactive adrenal tumors were, as a rule, an accidental sectional finding [24, 32, 38, 53]. Only with the introduction into wide clinical practice of highly effective diagnostic technologies (ultrasound - ultrasound, computed tomography - CT, magnetic resonance imaging - MRI, selective angiography, etc.) did real possibilities for intravital diagnosis of these tumors appear, as evidenced by the steadily increasing number of publications [ 18, 19, 41, 48, 53, 58, 82]. However, at present, in most cases, incidentalomas are detected by chance during a comprehensive study of the abdominal organs, carried out for some other reason, not related to the pathology of the adrenal glands. Thus, most authors use the term “incidentaloma” to refer to an accidentally detected adrenal tumor [20, 22, 30, 41, 48, 53, 58].
E. J. Pavlik, ed. Estrogens, progestins and their antagonists. - Vol. 2. Functions and mechanisms of action. - Boston, Basel, Berlin: Bikhauser, 1996 .-- 632 p.
Authors: Bershtein L. M.
Published: September 2019

The book under review is part of a lengthy and interesting series for specialists, published by the Birkhauser Publishing House and having the common title Hormones in Normal and Pathological Conditions. The first volume of the book, a review of which is published in Issue 3 of the journal “Oncology Issues” for 1997, deals mainly with the degree of oncological risk of estrogen replacement therapy in menopause, about the not always unambiguous anticarcinogenic properties of phytoestrogens and food indoles, and about modern approaches to hormone therapy for prostate cancer, etc., i.e., mainly about the problems of oncological endocrinology. The 2nd volume of this publication, as its editor E. Pavlik writes in the introduction to the book, is devoted to the physiological and molecular mechanisms of action of estrogens, progestins and their antagonists, and is primarily focused on the discussion of the effect of various and often even opposite effects these compounds in different cells and tissues. A highly qualified team of authors, assembled by the editor, was able to ensure the implementation of this difficult and responsible task.
Electrokinetic potential of blood lymphocytes in autoimmune ophthalmopathy in patients with diffuse toxic goiter
Authors: Rodionova T. I. , Ledvanov M. Yu. , Firstova V. V.
Published: September 2019

Electrophoretic mobility (ЕРМ) of blood lymphocytes was studied in 103 patients with diffuse toxic goiter (DTG) and autoimmune ophthalmopathy (AO) and 30 healthy controls in order to assess the value of this parameter as a criterion of AO severity and assessment of the efficacy of therapy of AO. The patients were in a state of drug-induced euthyrosis. A О was treated traditionally (nonsteroid antiinflammatory drugs, glucocorticoids, and glucocorticoids combined with radiotherapy of the orbits), depending on the severity of the condition. The distribution of blood lymphocytes by EPM is notably changed in AO. The electrokinetic potential of lymphocytes inversely correlates with the severity of AO. Specific therapy for AO results in increase of lymphocyte EPM in 14 days and its normalization in 28 days. Significant changes of lymphocyte EPM anticipate the statistically significant positive changes of the orbital index and can serve as an early criterion for assessing the efficacy of treatment of AO.
The role of the soluble form of the intercellular adhesion molecule ICAM-1 in the early diagnosis and evaluation of the effectiveness of the treatment of autoimmune ophthalmopathy in patients with diffuse toxic goiter
Authors: Rodionova T. I. , Ledvanov M. Yu.
Published: September 2019

sIСАМ-1 was measured in the sera of 156 patients with diffuse toxic goiter (DTG). The majority (105) of these patients presented with clinical signs of autoimmune ophthalmopathy (AO), and the above parameter was measured in order to assess the probability of using it as a criterion of preclinical diagnosis of AO and assessment of the efficacy of its therapy. Five groups of patients were distinguished in the course of study: 1) DTG without AO (n = 27); 2) zero stage of AO (no clinical manifestations) (n = 24); 3) stage I AO (n — 22); 4) stage II AO (n = 60); and 5) stage III AO (n = 23). All patients were in a state of drug-induced euthyrosis; AO of the first-third stages wasttreated traditionally (nonsteroid antiinflammatory drugs, glucocorticoids, radiotherapy of the orbits). Significant changes in sICAM-1 concentration were recorded in DTG patients as early as during the zero stage of AO without apparent clinical signs and confirmed only by computer- aided tomography of the orbits; this result recommends this parameter as an early marker of AO. Serum sICAM-1 content was notably increased in DTG patients with AO, the increase depending on the severity of AO. Changes of si CAM-1 correlated with the clinical picture of the condition (time course of the orbital and muscle index and size of the orbit) and can be used as an additional criterion for assessing the efficacy of treatment of AO.
To the diagnosis of Barraquer-Simons syndrome
Authors: Murakhovskaya E. V. , Starkova N. T.
Published: September 2019

Barraquer-Simons syndrome is a rare disease characterized by the disappearance of subcutaneous fat in the upper half of the body with normal or excessive deposition of fat in the lower half of the body. There are other terms that refer to this disease: Hollander-Simons syndrome, progressive lipodystrophy, partial lipodystrophy, paradoxical lipodystrophy, progressive segmental lipodystrophy, i.e. the name emphasizes the disappearance of fat in certain parts of the body.
To help patients with hypothalamic-pituitary disorders (patient's school)
Authors: Romantsova T. I. , Chernogolov V. A. , Pavlova M. G.
Published: September 2019

There are many reasons for the pathological increase in prolactin levels in the blood (hyperprolactinemia). Even minimal stress, such as taking blood for research, can lead to a short-term increase in prolactin levels. Medications such as antiemetics (metoclopramide, raglan, cerucal), psychotropic (chlorpromazine), and birth control pills can increase hormone levels. If you have an elevated prolactin level in your blood test, be sure to tell your doctor about taking these drugs. Hyperprolactinemia can also be caused by thyroid insufficiency (hypothyroidism), which is easily detected by measuring the level of thyroid-stimulating hormone in the blood and is well compensated against the background of thyroid hormone replacement therapy (L-thyroxine). After the examination excludes the presence of a number of endocrine and non-endocrine diseases, a conclusion is drawn on the existence of an independent hypothalamic-pituitary pathology - hyperprolactinemic hypogonadism (GH).
E.V. Kuleshov, S.E. Kuleshov. Diabetes mellitus and surgical diseases. - M., 1996 .-- 216 p.
Authors: Dedov I. I. , Kuznetsov N. S.
Published: September 2019

In recent years, there has been a significant increase in the number of patients with diabetes. According to WHO (1988), up to 5% of the world's population suffers from this disease. This is facilitated by stress, adynamia, excessive nutrition, uncontrolled drug therapy, viral infections, hereditary predisposition, adverse environmental conditions, developmental abnormalities, etc.
A family of xenobiotics that stimulate the secretion of growth hormone, and a new physiological system for its regulation
Authors: Bulatov A. A.
Published: September 2019

The history of discovery of low-molecular xenobiotics of peptide and поп-peptide origin selectively stimulating growth hormone (GH) secretion is presented and the properties of this family are described. Results of study of these synthetic GH secretogogues, their physiological effects and mechanisms of in vitro and in vivo action, relationships with GH releasing hormone (GH- RH) and somatostatin (SS), classical natural regulators of GH secretion, underlie the discovery of a heretofore unknown physiological system regulating normal pulsatile secretion of GH in interactions with GH-RH and SS and their receptors. This system includes a unique G-protein coupled receptor which was detected in the pituitary, hypothalamus, and hippocampus and was recently cloned, and endogenous ligand of this receptor, apparently a structural and functional analog of the above xenobiotics.
RESÚMENES DE TESIS: MAESTRÍA EN DIDÁCTICA DE LAS CIENCIAS EXPERIMENTALES
Authors: Vignatti Maria Del Carmen
Published: September 2019

Factores actitudinales y contextuales que inciden en la incorporación de TIC a la enseñanza de Biología en una escuela Secundaria.Sandra Rosa Larraburu
¡Hasta pronto maestras del siglo XXI! Una nueva vida os espera
Authors: Roz Sonia de la
Published: September 2019

La función del maestro ha cambiado radicalmente. Desde aquellos lejanos años en que inicié mi labor docente, donde la función principal del maestro consistía en administrar y regular todos los aspectos de la vida académica, hasta nuestros días, han aparecido numerosos desafíos, tanto profesionales como sociales, que las futuras maestras y maestros tendrán que afrontar. ¿Qué valores, qué perfil, qué rasgos personales han de tener aquellos estudiantes que se enfrentan a un contexto profesional tan complejo? Os invito a leer este texto que, en forma de cuento, trata de expresar lo esencial: para construir un gran maestro necesitamos partir de una gran persona.
Infometrics Growth Analysis of Medical Science Researchers in Nigeria during 2007 to 2016
Authors: Durodolu Oluwole O. , Adeleke Akinniyi A. , Ojo Joshua Onnade
Published: September 2019

This article accounts for the trend and pattern of medical research in Nigerian Universities within the span of ten years. The study aims to evaluate the research productivity of Nigerian Medical Science Researchers, appraise the preferred research communication outlets, analysing the growth rate of Nigerian medical science research publications, productivity, and visibility of both author and institution. Also, the trends of collaboration with colleagues within the continent and intercontinental were reviewed. The documents included in this research were retrieved from Scopus database; the results revealed incremental research output in medical science between 2007 and 2016 with 2016 having the highest number. It also showed that the Nigerian Journal of Clinical Practice is the most widely patronised by Nigeria Medical researchers and that the growth rate of research productivity is 9.5 per cent as indicated by the T value of 0.094768. Moreover, the researcher with the highest output was credited with 103 publication, while the trend of inter-continental research collaboration of Nigerian medical sciences researchers with scholars from another part of the world was more with the United States researchers.
Impact of International Coauthorships to A Young Malaysian University Specializing in Science, Technology, Engineering and Mathematics (STEM)
Authors: Ng Cheng Yee , Mustaffa Zahiraniza , John Kurian V
Published: September 2019

Internationalization is defined as a process of integrating an international, intercultural, or global dimension into the teaching and learning of education.  International co-authorship in research article is one of the means of collaboration towards internationalization.  This paper investigates the impact of international co-authorship in the field of Science, Technology, Engineering and Mathematics (STEM) for a specialised young university (<50 years old).  The study focused on approximately 9450 articles and the citations ranging from 2012-2017.  The impact due to annual article publication, annual citation count, most cited article, annual citation per article and the correlation between the publication and citation were analysed. The finding shows that faculty members of the university have been collaborated with authors from 86 countries since 1997, which dominated by Asian institutions.  Amongst, top 30 countries with highest international co-authored publications were identified, which led by Pakistan, Saudi Arabia, India, United Kingdom and Japan.  Further in detail, annual citation per article (Cpp) showed that collaborations with European countries e.g. Spain, Netherlands, and Hungry, resulting greater mean Cpp.  On the other hand, the analysis on the cumulative citation trend illustrated that the citation count is proportional to the number of articles.  This study evinced that international co-authorship does show positive impacts to a STEM specialised young university.
HOT SPOT ANALYSIS OF MOTORCYCLES OWNERSHIP IN PADURENAN, RAHTAWU AND WONOSOCO VILLAGE, KUDUS REGENCY
Authors: Intakoris Sam'ani , Soetomo Sugiono , Buchori Imam
Published: September 2019

Urban and rural interaction is a very important relationship, which rural functions as a supplier of natural and human resources to urban areas, while urban provides income streams, processed goods, and income to rural areas. Transportation became one of the main media as a link. The choice of transportation mode is one of the alternatives in creating an effective and efficient movement system. The motorcycle is the preferred mode of transportation because it is able to change direction very flexible compared to other modes of transportation. There is one unique phenomenon happening in Padurenan, Rahtawu and Wonosoco, Kudus Regency. The low transportation access was inversely proportional to the number of motorcycle ownership in the three villages. Thus, there needs to be a spatial pattern mapping of motorcycles ownership in three villages. This research aims to map spatial ownership of motorcycles in the three villages. It used average nearest neighbor, incremental spatial autocorrelation, hotspot analysis. The analytical tool used Arc GIS 10 as GIS (Geographic Information System) software. The result of this research showed that the distribution of the motorcycles ownership forms a cluster pattern. The highest concentration of motorcycle ownership cluster is seen in Padurenan Village, while the lowest cluster of motorcycle ownership is in Wonosoco Village.
IMPACT OF GOVERNANCE PERFORMANCE ON THE INDONESIAN MAP STANDARDISING PROCESS
Authors: Muhamad Nabiha Zain
Published: September 2019

The lack of standardised thematic maps in Indonesia has lead to many land ownership conflicts on the ground. The problem began since Indonesia started to exploit its natural resources by giving up its management to the market in the early 1960s. Concessions to exploit natural resources were given out without adequate assessment to real potential value of the resources. Mapping of concession areas by respective ministries without any standardised method or reference lead to the production of multiple official maps that conflict one another. Efforts to standardise the conflicting maps were initiated in 2011 and is currently still ongoing. This study aims to derive governance performance indices that directly or indirectly affect the map standaridising process. This study interviewed sources related to either the policy making process at the national level; government officials executing the policy at the provincial level and those affected by the conflict and other stakeholders advocating their rights. Interviewees include a number of officials in the central government both current and when the initiative were launched, provincial government and at the village level. To achieve sustainable development in environmental management, good governance is a prerequisite. However, the study found that sectoral ego and low government performance including, among others, corruption played a big role in hindering the process. By adding governance performance indices along with natural and economic variables to a forecast model, it can be predicted when Indonesia will likely to achieve its ideal level of harmonised maps.
SPATIAL STATISTICS FOR SOLID WASTE GENERATION MAPPING IN TEMBALANG, SEMARANG CITY
Authors: Ardiansyah Septa Yudha , Maryono Maryono
Published: September 2019

The annually increasing number of urban population will have impacts on waste generation. Tembalang Sub-district as a sub-district located on the outskirts of Semarang City has significant developments in the term of population growth in correlation with waste generation. Within four years, waste generation in the Tembalang Sub-district increased from the fifth rank to the third rank. It is possible that this sub-district will become the first rank in Semarang City in waste generation. To be able to identify influential factors and spatial distribution pattern of waste generation in Tembalang Sub-district, it is necessary to apply statistical and spatial approach. This study uses quantitative methods with a statistical spatial analysis approach by using GIS. In addition, this research also intends to model the relationships of Solid Waste Generation by applying socio-economic variables. Based on the results of Ordinary Least Square analysis, social economy variables that affect the amount of waste generation in Tembalang Sub-district are the number of population and trading activities. The model of formed socio-economic variables has the effect of 25% towards the amount of waste generation. Spatial patterns identified from waste generation shows that what needs to be considered is the waste management in TPS (Temporary Waste Disposal) in Tembalang and Sendangmulyo.
Hydrolyzation of duck meat protein using Bacillus cereus TD5B protease, pepsin, trypsin and their potency as an angiotensin converting enzyme inhibitor
Authors: Winarti A. , Rahmawati F. , Fitriyanto N. A. , Jamhari J. , Erwanto Y.
Published: September 2019

This study was aimed to explore their potency of protein-bioactive of native ducks-meat after enzymatic hydrolysis by Bacillus-cereus TD5B-protease, Pepsin, and Trypsin as an angiotensin-converting enzyme (ACE) inhibitor. The samples: ducks-meats from 10 months age of male Mojosari and Magelang-Duck. The experiments: individually hydrolysis of meat-protein using protease-enzyme (0.1 % w/w) from Bacillus-cereus TD5B, Pepsin, or Trypsin. The observed parameters: protein concentration, protein molecular weight, ACE-inhibitor activity, and IC-value (IC50). Data of protein concentration were statistically analyzed using T-Test, while data of SDS-PAGE and ACE-inhibiting activity were analyzed descriptively. The results showed that soluble protein concentration increased due to the hydrolysis process, from 0.826±0.108 mg/mL to 1.050±0.197 mg/mL (Microbial-protease), 2.122±0.141 mg/mL (pepsin), 1.641±0.071 mg/mL (trypsin) for Mojosari-duck and 0.642±0.038 mg/mL to 1.171±0.534 mg/mL(Microbial-protease), 2.100±0.376 mg/mL(pepsin), 1.725±0.092 mg/mL(trypsin) for Magelang-duck. The SDS-PAGE pattern showed that there was a decrease of molecular weight of duck-meats due to the hydrolysis process, from the range of 196.53-43.88 kDa to the range of 71.35-10.12 kDa. Duck-meat protein hydrolysate had ACE-inhibiting activity 71.7%(Mojosari-Microbial-Protease) IC50 54μg/mL, 57%(Mojosari-Pepsin) IC50 151μg/mL, 75.8%(Mojosari-Trypsin) IC50 51μg/mL and 52.8%(Magelang-Microbial-Protease) IC50 83μg/mL, 78,5%(Magelang-Pepsin) IC50 85μg/mL, 83.9%(Magelang-Trypsin) IC50 22μg/mL. In conclusion, hydrolysate of Magelang duck-meat used Trypsin had better potency as an ACE-inhibitor.
Production, quality and livestock carrying capacity of Panicum maximum and Sesbania grandiflora at saline soil with different manure application
Authors: Kusmiyati F. , Pangestu E. , Surahmanto S. , Purbajanti E.D. , Herwibawa B.
Published: September 2019

The objective of this study was to evaluate the effect of manure at saline soil on forage production, quality and livestock carrying capacity of P. maximum and S. grandiflora. The research was conducted on moderately saline soil at Rembang Regency, Central Java Province, Indonesia.Randomized complete block design was used as design experiment. The treatments were different dosage of manure as organic amendment (0, 10 and 20 tonnes/ha). Forage crops were P. maximum and S. grandiflora that planted monoculture or mixed-cropping. Parameters measured were dry matter (DM) production, ash, crude protein, crude fibre, ether extract, total digestible nutrients. P. maximum was cut eight times, S. grandiflora was cut six times during one year. The result showed that the highest total dry matter production of mixed cropping P. maximum and S. grandiflora was available at moderately saline soil with application 20 ton/ha manure. Total production of dry matter, crude protein and total digestible nutrient available at application 20 ton/ha manure were 29131 kg/ha/year; 3722 kg/ha/year and 17718 kg/ha/year, respectively. Carrying capacity based on dry matter, crude protein and total digestible nutrients were 10.8 AU/ha/year; 13.6 AU/ha/year and 11.3 AU/ha/year, respectively. In conclusion, application of 20 ton/ha manure at saline soil increased production, crude protein and carrying capacity.
YÜKSELEN PİYASALARDA ULUSLARARASI FİNANSAL YAYILIMLAR
Authors: KUBİLAY Mustafa Murat , SÖYLEMEZ Arif Orçun
Published: September 2019

Bu çalışmada

önde gelen 18 yükselen piyasa ekonomisi ile seçilmiş bir grup ekonomi (yükselen

ya da gelişmiş) arasındaki finansal etkileşimleri test etmek amacıyla  ülkelerin döviz, tahvil ve hisse senedi

piyasaları arasındaki getiri ve risk yayılımlarına bakılmıştır. Çalışmada

2010-2016 arasını kapsayan bir veriseti kullanılarak VAR ve çok değişkenli

GARCH BEKK modelleri ile tahminlerde bulunulmuştur. Sonuç olarak gelişmiş

piyasaların yükselen piyasalara kıyasla her üç piyasada daha fazla getiri

yayılımına neden oldukları tespit edilmiştir. İkinci olarak en yüksek finansal

gelişmişlik düzeyine sahip olan yükselen piyasa ülkelerinde getiri yayılımları

daha belirgindir. Üçüncü olarak getiri yayılımının en sık rastlandığı piyasa

tahvil; oynaklık yayılımının en çok bulunduğu ise hisse senedi piyasası

olmuştur. Finansal çeşitlendirme amacıyla farklı piyasalara yapılan

yatırımların sözkonusu yayılımlardan ötürü yükselen piyasalarda sınırlı başarı

sağlayacağı sonucuna varılmıştır. Bu çalışma uluslararası yatırımcıların getiri

ve risk analizlerine katkı sağlayacaktır. 
Legionella infection in pregnancy: imitator of HELLP syndrome, presenting as acute respiratory failure and septic shock
Authors: Gulersen Moti , Bornstein Eran
Published: September 2019

Background

Legionnaires’ disease in pregnancy may cause severe maternal complications. Hemolysis, elevated liver enzymes and low platelet count (HELLP) syndrome is a disorder associated with significant maternal and fetal morbidity and mortality. Several medical conditions have been described as imitators of this syndrome, presenting with similar laboratory abnormalities.

Case presentation

A healthy, multiparous woman presented at 26 weeks’ gestation with fever, headache and general malaise, rapidly progressing to septic shock and respiratory collapse. Laboratory evaluation revealed similar abnormalities to those seen with HELLP syndrome. Emergent cesarean delivery was performed for worsening maternal and fetal conditions. Following delivery, infection with Legionella was diagnosed on urinary antigen testing. Supportive care was administered in the intensive care unit.

Conclusion

Legionnaires’ disease should be considered in gravidas presenting with rapidly deteriorating respiratory status, septic shock and laboratory abnormalities mimicking HELLP syndrome.
Treating Rapid Responses as Incorrect for Non-Timed Formative Tests
Authors: Wright Daniel B.
Published: September 2019

When students respond rapidly to an item during an assessment, it suggests that they may have guessed. Guessing adds error to ability estimates. Treating rapid responses as incorrect answers increases the accuracy of ability estimates for timed high-stakes summative tests like the ACT. There are fewer reasons to guess rapidly in non-timed formative tests, like those used as part of many personalized learning systems. Data from approximately 75 thousand formative assessments, from 777 students at two northern California charter high schools, were analyzed. The accuracy of ability estimates is only slightly improved by treating responses made in less than five seconds as incorrect responses. Simulations show that the advantage is related to: whether guesses are made rapidly, the amount of time required for thoughtful responses, the number of response alternatives, and the preponderance of guessing. An R function is presented to implement this procedure. Consequences of using this procedure are discussed.
Exploration of Heterogeneous Treatment Effects via Concave Fusion
Authors: Ma Shujie , Huang Jian , Zhang Zhiwei , Liu Mingming
Published: September 2019

Understanding treatment heterogeneity is essential to the development of precision medicine, which seeks to tailor medical treatments to subgroups of patients with similar characteristics. One of the challenges of achieving this goal is that we usually do not have a priori knowledge of the grouping information of patients with respect to treatment effect. To address this problem, we consider a heterogeneous regression model which allows the coefficients for treatment variables to be subject-dependent with unknown grouping information. We develop a concave fusion penalized method for estimating the grouping structure and the subgroup-specific treatment effects, and derive an alternating direction method of multipliers algorithm for its implementation. We also study the theoretical properties of the proposed method and show that under suitable conditions there exists a local minimizer that equals the oracle least squares estimator based on a priori knowledge of the true grouping information with high probability. This provides theoretical support for making statistical inference about the subgroup-specific treatment effects using the proposed method. The proposed method is illustrated in simulation studies and illustrated with real data from an AIDS Clinical Trials Group Study.
Can there be a Finite Interpretation of the Kantian Sublime?
Authors: Golob Sacha
Published: September 2019

Kant’s account of the sublime makes frequent appeals to infinity, appeals which have been extensively criticised by commentators such as Budd and Crowther. This paper examines the costs and benefits of reconstructing the account in finitist terms. On the one hand, drawing ona detailed comparison of the first and third Critiques, I argue that the underlying logic of Kant’s position is essentially finitist. I defend the approach against longstanding objections, as well as addressing recent infinitist work by Moore and Smith. On the other hand, however, I argue that finitism faces distinctive problems of its own: whilst the resultant theory is a coherent and interesting one, it is unclear in what sense it remains an analysis of the sublime. I illustrate the worry by juxtaposing the finitist reading with analytical cubism.
Ultra-compact integrated graphene plasmonic photodetector with bandwidth above 110 GHz
Authors: Ding Yunhong , Cheng Zhao , Zhu Xiaolong , Yvind Kresten , Dong Jianji , Galili Michael , Hu Hao , Mortensen N. Asger , Xiao Sanshui , Oxenløwe Leif Katsuo
Published: September 2019

Graphene-based photodetectors, taking advantage of the high carrier mobility and broadband absorption in graphene, have recently seen rapid development. However, their performance with respect to responsivity and bandwidth is still limited by the weak light-graphene interaction and large resistance-capacitance product. Here, we demonstrate a waveguide-coupled integrated graphene plasmonic photodetector on a silicon-on-insulator platform. Benefiting from plasmon-enhanced graphene-light interaction and subwavelength confinement of the optical energy, a small-footprint graphene-plasmonic photodetector is achieved working at the telecommunication window, with a large a bandwidth beyond 110 GHz and a high intrinsic responsivity of 360 mA/W. Attributed to the unique electronic band structure of graphene and its ultra-broadband absorption, operational wavelength range extending beyond mid-infrared, and possibly further, can be anticipated. Our results show that the combination of graphene with plasmonic devices has great potential to realize ultra-compact, high-speed optoelectronic devices for graphene-based optical interconnects.
Crystal structure of (cyclohexane-1,4-diammonium) 4-[(4-carboxylatophenyl)disulfanyl]benzoate dimethylsulphoxide hydrate (1/1/1/1), [C6H16N2]2+[C14H8O4S2]2−⋅C2H6OS⋅H2O
Authors: Tan Sang Loon , Tiekink Edward R. T.
Published: September 2019

C22H32N2O6S3, triclinic, P1̄ (no. 2), a = 6.1543(1) Å, b = 14.4991(2) Å, c = 15.3859(3) Å, α = 64.545(2)°, β = 81.828(1)°, γ = 89.505(1)°, V = 1224.93(4) Å3, Z = 2, R
gt(F) = 0.0290, wR
ref(F
2) = 0.0787, T = 100 K.
Prion Evolvability and the Hazard of Atypical Scrapie in Small Ruminants
Authors: Adams David B.
Published: September 2019

Observations on strain behaviour and direct demonstrations of natural selection establish that the scrapie agent and prions in general are able to evolve. Accordingly, it is conceivable that atypical non-contagious scrapie in sheep and goats can transform to classical contagious scrapie under particular circumstances. In consequence, atypical scrapie can be regarded as a latent hazard that warrants comprehensive risk assessment and biosecurity preparedness planning. Evidence for this proposition comes from differences in the expression of atypical and classical scrapie that may make scrapie contagious, historical records of scrapie in Western Europe, and contemporary accounts of the epidemiology of atypical scrapie. Biosecurity preparedness can be based on current knowledge of pathophysiology and epidemiology and can be built around a three-stage model for the endogenous emergence of a propagating epidemic of scrapie. The first stage concerns the occurrence of atypical scrapie. The second stage concerns the acquisition of communicability in prion populations provided by atypical scrapie and the third stage concerns circumstances allowing disease transmission and the initiation of a propagating epidemic. The range of component causes envisaged for possible outbreaks of endogenous classical scrapie is broad. However, exposure of sheep and goats to cyanobacterial toxins qualifies for special attention.
Reactivity of fly ashes milled in different milling devices
Authors: Chu Yong-Sik , Davaabal Batmunkh , Kim Dae-Sung , Seo Sung-Kwan , Kim Yoo , Ruescher Claus , Temuujin Jadambaa
Published: September 2019

The effect of two different milling devices, namely attrition mill versus vibration mill, on the reactivity of fly ash was studied. High calcium fly ash from 4th Thermal power station of Ulaanbaatar (Mongolia) was used for the experiments. The raw and processed samples were characterized by XRD, SEM, Particle size distribution, BET, Blaine surface area and density measurements. The efficiency of 1 hour milling was evaluated with the Blaine surface area set to be more than 5000 cm2/g. The physical and chemical properties of the attrition milled fly ash changed not much compared to the vibration milled samples. For example the d50 particle size became reduced from 29 µm to 6 µm by attrition milling and in vibration milled fly ash it was reduced to 7 µm. The density increased from 2.44 g/cm3 of raw fly ash to 2.84 g/cm3 and 2.79 g/cm3 in attrition and vibration milled samples, respectively. Mechanical milling revealed not only a particle size reduction but also the formation of a denser microstructure. As a result the vibration milled fly ash showed a weaker interaction with the alkaline solution (8 M NaOH used here) compared to the attrition milled fly ash. Consequently, compressive strength of the binder prepared using the attrition milled fly ash was higher, 61 MPa, while for vibration milled fly ash it was 49 MPa. For comparison unmilled fly ash, it was 21 MPa.
Genetic Dissection Reveals the Role of Ash1 Domains in Counteracting Polycomb Repression
Authors: Dorafshan Eshagh , Kahn Tatyana G , Glotov Alexander , Savitsky Mikhail , Schwartz Yuri B
Published: September 2019

Antagonistic functions of Polycomb and Trithorax proteins are essential for proper development of all metazoans. While the Polycomb proteins maintain the repressed state of many key developmental genes, the Trithorax proteins ensure that these genes stay active in cells where they have to be expressed. Ash1 is the Trithorax protein that was proposed to counteract Polycomb repression by methylating lysine 36 of histone H3. However, it was recently shown that genetic replacement of Drosophila histone H3 with the variant that carried Arginine instead of Lysine at position 36 did not impair the ability of Ash1 to counteract Polycomb repression. This argues that Ash1 counteracts Polycomb repression by methylating yet unknown substrate(s) and that it is time to look beyond Ash1 methyltransferase SET domain, at other evolutionary conserved parts of the protein that received little attention. Here we used Drosophila genetics to demonstrate that Ash1 requires each of the BAH, PHD and SET domains to counteract Polycomb repression, while AT hooks are dispensable. Our findings argue that, in vivo, Ash1 acts as a multimer. Thereby it can combine the input of the SET domain and PHD-BAH cassette residing in different peptides. Finally, using new loss of function alleles, we show that zygotic Ash1 is required to prevent erroneous repression of homeotic genes of the bithorax complex in the embryo.
Die duale Rundfunkordnung als passende Regulierungsoption zur Korrektur des Marktversagens im Rundfunk
Authors: Kettering Emil , Köhler Lutz
Published: September 2019

Die medienökonomische Forschung belegt ein Marktversagen im Rundfunk aufgrund der Rundfunkeigenschaften als öffentliches Gut, subadditiver Kostenstrukturen, externer Effekte und Informationsmängel. Analysiert man die unabhängig vom Marktversagen entwickelte und historisch bedingt weitgehend durch die Rechtsprechung des Bundesverfassungsgerichts geprägte deutsche Rundfunkordnung vor diesem Hintergrund, zeigt sich, dass diese eine passende Regulierungslösung darstellt, um das Marktversagen zu korrigieren. Das System sichert Vielfalt und Qualität, schützt vor übermäßiger Konzentration und fördert Effizienz und Innovation. Das Verschmelzen von Rundfunk und Online sowie die Veränderungen im Nutzerverhalten und in den Nutzererwartungen machen aber eine technologieneutrale Weiterentwicklung der Regulierung erforderlich.
Drei-Stufen-Test
Authors: Dörr Dieter
Published: September 2019

Nach den Regelungen des am 1. Juni 2009 in Kraft getretenen Zwölften Rundfunkänderungsstaatsvertrags dürfen die meisten Online-Angebote des öffentlich-rechtlichen Rundfunks nur noch verbreitet werden, wenn sie erfolgreich den Drei-Stufen-Test durchlaufen haben. Hierbei ist sowohl das Verfahren als auch die Ausgestaltung im Einzelnen als nicht unproblematisch zu bewerten. Daher sollen der Hintergrund und die Ausgestaltung der Neuregelung in diesem Stichwort näher beleuchtet werden.
Programmies als Quotenmacher?
Authors: Lenz Michael , Tiele Annekaryn , Klimmt Christoph
Published: September 2019

Der Beitrag untersucht den Effekt der Programmpresse auf die Sehbeteiligung im Free-TV. Auch wenn die Fernsehauswahl größtenteils als Niedrigkostensituation durch habituelle Selektionsstrategien gekennzeichnet ist, so lassen sich doch gerade für entscheidende Programmslots wie den Sonntagabend elaborierte Publikumsentscheidungen unter Zuhilfenahme der Programmpresse vermuten. Zumindest für solche Sendezeiten würde den Programmzeitschriften entsprechend ein erheblicher Einfluss auf den TV-Publikumsmarkt zukommen. Um diese Annahme empirisch zu prüfen, werden die Größen der Filmankündigungen und -bewertungen in den TV-Zeitschriften mit den Marktanteilsdaten der GfK-Fernsehforschung abgeglichen. Die Ergebnisse können erstmals einen starken positiven Effekt der Ankündigungsgröße in den Programmzeitschriften auf den Sendungserfolg der Filme nachweisen, auch unter Kontrolle der Einflüsse von Kinoerfolg und Filmalter. Die Anwendungsimplikationen für die TV-Wirtschaft werden diskutiert.
Aktuelle Veränderungen im Pressevertrieb
Authors: Albrecht Kai-Christian , Brandt Torsten J.
Published: September 2019

Das deutsche Grosso-System steht derzeit zum wiederholten Male in der Diskussion. Hintergrund sind Kündigungen von Grosso-Verträgen verbunden mit der Frage der Effizienz des bisherigen Systems. Unter dem Titel „Aktuelle Veränderungen im Pressegrosso“ wird die Diskussion aufgegriffen und die Sichtweisen Beteiligter von Verlagsseite sowie von Grossistenseite dargestellt: Kai-Christian Albrecht, Geschäftsführer des Grosso-Verbands, bezieht ebenso Stellung wie Torsten J. Brandt, Verlagsgeschäftsführer der Axel Springer AG.
Anke Schäferkordt – ein Portrait
Authors: von Mirbach Beatrice , Mann Florian
Published: September 2019

Sie ist als „Lady in Red“ bekanntgeworden. Ob früher VOX oder jetzt RTL: Passend zur Unternehmensfarbe trägt die mächtigste Frau in der deutschen Fernsehlandschaft, Anke Schäferkordt, auch heute noch gern rot. Den roten Teppich jedoch meidet sie, wenn möglich. Schäferkordt steht trotz ihrer Position nicht gerne im Rampenlicht. Seit über vier Jahren leitet die 46-Jährige erfolgreich die Mediengruppe RTL Deutschland, zu der unter anderem die Sender RTL Television, VOX und n-tv gehören sowie Anteile an RTL II oder Super RTL, aber auch Unternehmen wie RTL interactive, der Werbezeitenvermarkter IP Deutschland, die Nachrichteneinheit infonetwork oder als technischer Dienstleister der gesamten Gruppe die CBC. Zugleich ist sie Geschäftsführerin des Fernsehsenders RTL Television.
Je individueller, desto besser?
Authors: Lehrer Christiane , Hess Thomas , Rauscher Barbara , Höhne Elisabeth
Published: September 2019

Die praktische Erfahrung mit individualisierten Medienangeboten sowie empirische Studien haben gezeigt, dass ein Mehr an Individualisierung nicht zwangsläufig zu einem höheren Kundennutzen und damit zu einer Erfolgssteigerung des Internetauftritts führt. Doch wie viel Individualisierung ist angemessen? Im Rahmen dieses Beitrags präsentieren wir einen konkreten Fahrplan, der es ermöglicht, den passenden Individualisierungsgrad für eine Webseite zu bestimmen.
Vergütungsmodelle bei Media-Agenturen
Authors: Niesel Manfred
Published: September 2019

Die Entwicklung zu großen Agentur-Networks, eine zunehmende Internationalisierung und damit die Veränderung der Machtstrukturen rücken die Thematik der Vergütung von Agenturleistungen in ein neues Licht. Speziell im Bereich der Media-Agenturen sind Veränderungen in der Honorierungspraxis festzustellen.
Die Duale Rundfunkordnung als passende Regulierungsoption?
Authors: Kettering Emil , Köhler Lutz , Schmid Tobias , Gerlach Petra
Published: September 2019

Die Medienwirtschaft hat sich in ihren letzten beiden Ausgaben ausführlich mit der dualen Rundfunkordnung beschäftigt. In der Rubrik Praxisforum 3/2009 formulierten zunächst Dr. Emil Kettering und Dr. Lutz Köhler ihre Sichtweise der dualen Rundfunkordnung, in der folgenden Ausgabe 4/2009 stellten Dr. Tobias Schmid und Dr. Petra Gerlach ihre Sicht der Dinge dar. Der folgende Leserbrief von Dr. Kettering und Dr. Köhler antwortet auf diese Replik. Dr. Schmid und Dr. Gerlach erhielten wiederum die Gelegenheit, diesen Leserbrief ebenfalls bereits in dieser Ausgabe zu kommentieren. Die Redaktion der Medienwirtschaft beendet mit diesen beiden Texten den Schlagabtausch der beiden Autorenteams. Die generelle Debatte wird aber sicherlich weitergehen.