bluuebunny/crossref_metadata_2025 huggingface dataset:
Production of Aluminum Matrix Composite Material by Active Carbon Additive
Authors: EISAY Ayman M. S. , TÜRKYILMAZ AYDIN
Published: March 2021

The effectiveness of composite materials with the addition of activated carbon produced from biomaterial with a new application on aluminum-based composite materials was investigated in this study.Activated carbon was produced from the peanut shells via the chemical activation method and the obtained activated carbon was mixed with aluminum and composite material. For the characterization of the composite material obtained, XRD and SEM-EDS optical photographs were assessed in the experimental process. According to Vickers Hardness and Dynamic Micro Hardness results, the sample with the hardness value of 2% AC added had the highest hardness value. The elastic modulus values was found to increase by 3.4 times (9.59GPa) compared to aluminum with the addition of 2% activated carbon. This increases with activated carbon quantity, and weakens the matrix structure due to weak van der waals interaction with aluminum, which reduces hardness; therefore, the best ratio of the activated carbon reinforcement to the aluminum matrix was obtained at 2% activated carbon addition.
Outcome Measures in Solid Organ Donor Management Research - a Systematic Review
Authors: Bera Kasia D , Shah Akshay , English  , Ploeg RJ
Published: March 2021

BackgroundTo systematically review published outcome measures across randomised controlled trials (RCTs) of donor management interventions. MethodsThe systematic review was conducted in accordance with recommendations by the Cochrane Handbook and PRISMA statement. We searched MEDLINE, EMBASE, CENTRAL, Web of Science as well as trial databases from 1980 to December 2019 for RCTs of donor management interventions. ResultsTwenty-two RCTs (n = 3432 donors) were included in our analysis. Fourteen RCTs (63.6%) reported a primary outcome relating to a single organ only. Eight RCTs primarily focused on aspects of donor optimisation in critical care. Thyroid hormones and methylprednisolone were the most commonly evaluated interventions (five and four studies, respectively). Only two studies, focusing on single organs (e.g. kidney), evaluated outcomes relating to other organs. The majority of studies evaluated physiological or biomarker-related outcomes. No study evaluated recipient health-related quality of life. Only one study sought consent from potential organ recipients. ConclusionsThe majority of RCTs evaluating donor management interventions only assessed single organ outcomes or effects on donor stability in critical care. There is a need for an evaluation of patient-centred recipient outcomes, and standardisation and reporting of outcome measures for future donor management RCTs. PROSPERO RegistrationCRD42018109487
Modified Formulas for Calculation of Encephalization Quotient in Dogs
Authors: Saganuwan Saganuwan Alhaji
Published: March 2021

ObjectiveDogs are a breed of animals that play important roles, ranging from security passing through companionship to models of research for application in humans. Intelligence is the key factor to success in life, most especially for dogs that are used for security purposes at the airports, seaports, public places, houses, schools and farms. However, it has been reported that there is correlation between intelligence, body weight, height and craniometry in human. In view of this, literatures on body weight, height and body surface areas of ten dogs were assessed with a view to determining their comparative level of intelligence.ResultsFindings revealed that dogs share brain common allometric relationships with human as shown by Encephalization Quotient (EQ)= Brain Mass/0.14 x Body weight0.528 as compared with Brain Mass /0.12 x Body Weight0.66 and Brain Mass (E)=kpβ, where p is the body weight,k=0.14 and β=0.528 which yielded better results as compared with the other formulas. Dogs with BSA, weight and height similar to that of human are the most intelligent. Doberman Pinscher is the most intelligent followed by German Shepherd, Labrador Retriever, Golden Retriever, respectively.
The Comparison of Exosome RNA Concentration and its LMP-1 and p53 content Among Patients with Nasopharyngeal Cancer before and after Chemoradiation
Authors: Kadriyan Hamsu , Prasedya Eka Sunarwidhi , Anwar Khairil , Pieter Nova Audrey L , Gaffar Masyita , Punagi Abdul Qadar
Published: March 2021

ObjectiveNasopharyngeal cancer (NPC) remains the highest head and neck malignancy in Asia, especially in Southeast Asia. The exosome is a nanocarrier that has a role in inhibit or promote the progression of cancer as well as the marker to knows the response of therapy depending on its carrier inside. NPC-exosome carriers including LMP-1 and p53. LMP-1 is a main oncogene of Epstein Barr Virus (EBV) the predominant cause of NPC. Wild type p53 known as the main inhibitor of cancer growth. The study aims to compare the concentration of exosomes and the characteristic of LMP-1 and p53 inside exosomes among patients with NPCResultEight patients fulfilled the study criteria. The mean age was 37,5 years old (SD = 9,9), most of them were stage III. The mean exosome RNA concentration before and after chemoradiation was 14,39 and 3,61 ng/ml with a p-value of 0,04. LMP-1 expression was documented inside the exosome. Expression of p53 in exon 4-5 and 5-6 are express well, except on exon 7-8. Furthermore, there was a significant increase of p53 expression relative to the housekeeping gene in exon 4-5 and 5-6 after chemoradiation with a p-value of 0,001 and 0,002 consecutively.
Shortcomings of SARS-CoV-2 Genomic Metadata
Authors: Gozashti Landen , Corbett-Detig Russell
Published: March 2021

ObjectiveThe SARS-CoV-2 pandemic has prompted one of the most extensive and expeditious genomic sequencing efforts in history. Each viral genome is accompanied by a set of metadata which supplies important information such as the geographic origin of the sample, age of the host, and the lab at which the sample was sequenced, and is integral to epidemiological efforts and public health direction. Here, we interrogate some shortcomings of metadata within the GISAID database to raise awareness of common errors and inconsistencies that may affect data-driven analyses and provide some possible avenues for solutions.ResultsOur analysis reveals a startling prevalence of spelling errors and inconsistent naming conventions, which together occur in an estimated ~9.8% and ~11.6% of “originating labs” and “submitting labs” GISAID metadata categories respectively. We also find numerous ambiguous entries which provide very little information about the actual source of a sample and could easily associate with multiple sources worldwide. Importantly, all of these issues can impair the ability and accuracy of association studies by deceptively causing a group of samples to identify with multiple sources when they truly all identify with one source, or vice versa.
Effects of FUdR on gene expression in the C. elegans bacterial diet OP50
Authors: McIntyre Grace , Wright Justin , Wong Hoi Tong , Lamendella Regina , Chan Jason P
Published: March 2021

Objective: Many C. elegans aging studies use the compound, 5-fluro-2’-deoxyuridine (FUdR), to produce a synchronous population of worms in aging studies. However, it is not fully clear what effects FUdR have on the bacterial gene expression in the E. coli strain OP50, the primary laboratory C. elegans food source. This is particularly relevant as studies indicate that intestinal microbes can affect C. elegans physiology. Here, we examine how exposure to FUdR can affect gene expression changes in OP50 E. coli. Results: RNAseq datasets were used to compare the expression patterns of E. coli genes in the strain OP50 seeded on either nematode growth media (NGM) plates or on FUdR (50µM) supplemented NGM plates. Analysis showed differential expression of genes involved in general transport, amino acid biosynthesis, transcription, iron transport, and antibiotic resistance. We specifically highlight metabolic enzymes in the L-histidine biosynthesis pathway may be regulated by FUdR exposed OP50. We conclude that OP50 exposed to FUdR results in many differentially expressed genes, including those in amino acid biosynthetic pathways.
Applicability of Human-specific STR systems, GlobalFiler™ PCR Amplification Kit, Investigator 24plex QS Kit, and PowerPlex® Fusion 6C in Chimpanzee (Pan troglodytes)
Authors: Singh Abhishek , Sahajpal Vivek , Thakur Mukesh , Sharma Lalit Kumar , Chandra Kailash , Bhandari Deepika , Sharma Arun
Published: March 2021

Objectives

The human identification systems based on STRs are widely used in human population genetics and forensic analysis. This study aimed to validate the cross-reactivity of three widely known Human-specific STR identification systems i.e. GlobalFiler™ PCR Amplification Kit, Investigator 24plex QS Kit, and PowerPlex® Fusion 6C in Chimpanzee.
Result

The present study revealed the successful amplification of 18 loci using GlobalFiler™ PCR Amplification Kit, 18 loci using Investigator 24plex QS Kit, and 20 loci using PowerPlex® Fusion 6C system. The marker Amelogenin (AMEL) showed differential allele size between male and female revealing the gender identity of Chimpanzees and thus validates their application concerning forensic examination, population estimation, and genetic analysis.
Extracellular Vesicles-based Pre-Targeting Strategy Enables Multi-Modal Imaging of Orthotopic Colon Cancer and Image-Guided Surgery
Authors: An Rui , Jing Boping , Qian Ruijie , Jiang Dawei , Gai Yongkang , Liu Zhen , Guo Feng , Ren Sen , Gao Yu , Lan Xiaoli
Published: March 2021

BackgroudColon cancer contributes to high mortality rates as the result of incomplete resection in tumor surgery. Multimodal imaging can provide preoperative evaluation and intraoperative image-guiding. As biocompatible nanocarriers, extracellular vesicles hold great promise for multimodal imaging. In this study, we aim to synthesized an extracellular vesicles-based nanoprobe to visualize colon cancer with positron-emission tomography/computed tomography (PET/CT) and near-infrared fluorescence (NIRF) imaging, and investigated its utility in image-guided surgery of colon cancer in animal models. ResultsExtracellular vesicles were successfully isolated from adipose-derived stem cells (ADSCs), and their membrane vesicles were observed under TEM. DLS detected that the hydrodynamic diameters of the extracellular vesicles were approximately 140 nm and the zeta potential was −7.93 ± 0.24 mV. Confocal microscopy showed that extracellular vesicles had a strong binding ability to tumor cells. A click chemistry-based pre-targeting strategy was used to achieve PET imaging in vivo. PET images and the biodistribution results showed that the best pre-targeting time was 20 h, and the best imaging time was 2 h after the injection of 68Ga-L-NETA-DBCO. The NIRF images showed that the tumor had clear images at all time points after administration of nanoparticles and the Tumor/Muscle ratio peaked at 20 h after injection. Our data also showed that both PET/CT and NIRF imaging clearly visualized the orthotopic colon cancer models, providing preoperative evaluation. Under real-time NIRF imaging, the tumor location and tumor boundary could be clearly observed. ConclusionsIn brief, this novel nanoprobe may be useful for multi-modal imaging of colon cancer and NIRF image-guided surgery. More importantly, this study provides a new possibility for clinical application of extracellular vesicles as nanocarriers.
Mineral Prοpecting and Lithοlοgical Mapping Using Remοte Sensing Apprοaches in Between Yazihan-Heki̇mhan (Malatya) Turkey
Authors: SEVİMLİ ULAŞ İNAN , TRAORE MAMADOU , TOPAK YUSUF , TEKİN SENEM
Published: March 2021

The Remote Sensing processing analysis have become a directing and hopeful instrument for mineral investigation and lithological mapping. Mineral exploration in general and bearing chromites associated with ultrabasic and basic rocks of the ophiolite complex in particular has been successfully carried out in recent years using Remote Sensing techniques. Yazıhan-Hekimhan (Malatya) region of East Taurus mountain belt, ranks second in terms of iron mineralization in Turkey are accepted. The area is characterized by high grade iron ore deposits in use, development and exploration. Lithological mapping and chromite ore exploration of this area is challenging owing to difficult access (High Mountain 2243 m) using the traditional method of exploration. The main objective of this research is to evaluate the capacity of Landsat-8 OLI and Advanced Spaceborne Thermal Emission and Reflection Radiometer (ASTER) satellite imagery to discriminate and detect the potential zone of chromites bearing mineralized in Malatya (Yazıhan). Several images processing techniques, Vegetation Mask, Band Ratio (BR), Band Ratio Color Composite (BRCC), Principal Component Analysis (PCA), Decorrelation Stretch, Minimum Noise Fraction and Supervised classification using Spectral Angle Mapper (SAM) exist in previous studies have been performed for lithological mapping. The obtained results show that, BR, PCA and Decorrelation Stretch methods applied on NVIR-SWIR bands of Landsat-8 and ASTER were clearly discriminate the ophiolite rocks at a regional scale. In Addition, SAM classification was applied on a spectral signature of differents ultrabasic and basic rocks extracted from ASTER data. The results are promising in identifying the potentials zones of chromite ore mineralization zones within the ophiolite region. Thus, the techniques used in this research are suitable to detect or identify the high-potential chromite bearing areas in the ophiolite complex rocks using Landsat-8 OLI and ASTER data.
The prevalence of hepatic steatosis and metabolic associated fatty liver disease among breast cancer survivors
Authors: Tian Shen , Li Hao , Li Ren-hua , Ran Liang , Li Shu , Wu Juan , Xu Zhou , Liang Xin-yu , Chen Yu-ling , Xiao Jun , Wei Jia-ying , Ma Chen-yu , Song Jing-yu , She Rui-ling , Wu Kai-nan , Kong Ling-quan
Published: March 2021

Background and aimsAn international expert consensus statement was released on 2020 that non-alcoholic fatty liver disease (NAFLD) should be replaced by metabolic associated fatty liver disease (MAFLD) and hepatic steatosis (HS) is fundamental for the diagnosis of MAFLD in the new set of criteria. While female breast cancer has surpassed lung cancer as the most commonly diagnosed malignant tumor and shares the same risk factors with HS and MAFLD, but their prevalence in breast cancer survivors (BCS) is unknown. Herein, we employed the liver ultrasound elastography (USE), a more sensitive detector for HS diagnosis, to explore the more accurate prevalence of HS and MAFLD among BCS.MethodA total of 263 BCS with conventional liver ultrasonography (US) and USE tests, followed up in the clinic of the Breast Cancer Center of Chongqing, as well as age and sex matching controls (1:10) with US test, from 135,436 healthcare population in the Quality Control Center of Health Examination of Chongqing of the First Affiliated Hospital of Chongqing Medical University, were enrolled. Both US and USE were implemented to diagnose HS. Afterwards the anthropology information and relative laboratory test results were collected to estimate the prevalence of MAFLD based on USE and US according to the 2020 international consensus.ResultsThe prevalence of HS detected by US in BCS was significantly higher than that in healthcare population (41.8% vs. 22.4%, P<0.001), and it rose to 69.6% when the BCS were screened by USE. Accordingly, the prevalence of MAFLD based on US in BCS was also significantly higher than that in healthcare population (39.5% vs. 21.2%, P<0.001) and it rose to 63.5% when the BCS were screened by USE. The prevalence of HS and MAFLD based on US in elderly BCS (≥60 yr) were obviously higher than those in healthcare population (56.7% & 56.7 % vs. 31.3% & 30.7%, P<0.001), respectively, and they rose to 80.0% and 73.3%, respectively when the BCS were screened by USE.ConclusionHS and MAFLD prevail in breast cancer survivors, especially in most of the elderly breast cancer survivors (≥60 yr). Their prevalence are much higher than in the general population. Early prevention, diagnosis and treatment of HS and MAFLD in breast cancer survivors should be implemented.
Optimizing Chinese Story Generation Based on Multi-channel Word Embedding and Frequent Pattern Tree Structure
Authors: Lin Jhe-Wei , Chang Rong-Guey
Published: March 2021

Much space remains for generating stories in the Chinese language. In this paper, we propose a novel approach to address this issue by multi-channel word embedding and effective control of the part-of-speech structure while producing sentences to imitate the writing style. The proposed approach consists of four parts: We first preprocess the sentences to label all sentences in the data set according to the format of   , where  , and  represent the beginning, the end of the sentence, and the separation between sentences. We then propose a multi-channel method to embed words by integrating traditional vectorization methods including Word2vec, Fasttext, LexVec, and Glove to improve the information in the input data. We next optimize the model architecture to effectively control the process of sentence generation based on the BERT (Bidirectional encoder representations from) model. Finally, we perform some optimization on performance. For example, Softmax function in the model was optimized to reduce the search time during training. In addition, the GAN (generative adversarial network) architecture for the data set was revised to improve the training performance of the model. All sentences in the data set are built into a tree structure and the part-of-speech structure of the next sentence was generated through model generation based on FP-tree. The experimental results show that the proposed method can effectively control the generation of Chinese stories.
Estimated renal function and cardiovascular or non-cardiovascular mortality in community population: results from the national health and nutrition examination surveys
Authors: Huang Jieleng , Wei Xuebiao , Jiang Mei , Su Zedazhong , Yang Zhiwen , Lin Yingwen , Chen Jiyan , Yu Danqing
Published: March 2021

Background

Renal insufficiency is an important risk factor for mortality in various populations. The present study was conducted to determine the optimal equation for the estimation of renal function in predicting adverse events in community population in US.
Methods

We examined the Cockcroft–Gault, modification of diet in renal disease (MDRD), Mayo Healthy-Chronic Kidney Disease (Mayo), and Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) derived estimated glomerular filtration rates (eGFR) and the association with cardiovascular or non-cardiovascular mortality among 25,677 participants of US National Health and Nutrition Examination Survey from 2005 to 2014.
Results
The cardiovascular mortality and non-cardiovascular mortality increased with decrease in renal function. The MDRD derived eGFR exhibited the lowest predictive ability for all-cause mortality in all participants. For cardiovascular mortality, the Cockcroft–Gault derived eGFR exhibited the highest predictive power compared with the MDRD (area under the curve [AUC]: 0.842 vs. 0.764, p < 0.001), Mayo (AUC: 0.842 vs. 0.812, p < 0.001) and CKD-EPI (AUC: 0.842 vs. 0.813, p < 0.001) derived eGFR. For non-cardiovascular mortality, the Cockcroft–Gault derived eGFR exhibited similar superiority in non-cardiovascular mortality.
Conclusions

The value of the Cockcroft–Gault equation was superior to the other three equations for the prediction of cardiovascular or non-cardiovascular mortality in community population. This equation can serve as a risk-stratification tool for long-term events in community population.
Intraoperative Frog Lateral View, An Effective and Easy Way to Avoid Screw Cutout for Femoral Neck Fractures Fixed with Multiple Cancellous Screws
Authors: Dong Xin , Wang Hongnian , Wang Bao , Li Yongdong , Zhang Tao
Published: March 2021

BackgroundThis study analyzed the imaging data of patients retrospectively to understand the risk of cannulated screw fixation for femoral neck fracture. At the same time, we try to use intraoperative frog lateral view to avoid the risk of screw cutout.MethodThe imaging data of patients with femoral neck fracture treated with cannulated screws between January 2015 and September 2016 was reviewed, and patients with screw cutout or suspicious cutout were found. The postoperative imaging data of 41 patients who attempted to use frog lateral view during the operation was reviewed,and patients with screw cutout or suspicious cutout were found.ResultAmong the 479 patients, only 72 patients underwent CT examination after the operation, and 18 of the 72 patients had obvious screw cutout. Screw cutout cases accounted for 3.8% of the total number of cases and 25% of the patients undergoing CT examination. Of the 41 patients who received intraoperative frog lateral view, only 2 cases were cutout from the neck, and no cases were cutout from the femoral head.ConclusionThe anterior upper part of the femoral head is a high-risk area cutout by cannulated screws. Postoperative CT is very necessary and can accurately detect the screw cutout, for the long-term prognosis of the implications. The application of frog lateral view in the operation of femoral neck fracture can effectively avoid the risk of cannulated screw cutout.
A solution to the challenges of particle erosion and thermal cycle for PS-PVD 7YSZ thermal barrier coatings
Authors: Zhang Xiaofeng , Li Ming , Zhang Yan , Deng Ziqian , Fan Jiafeng , Zhuo Xueshi , Yin Juhang , Guo Shuangquan , Mao Jie , Deng Chunming , Lai Cheng , Wang Panpan , Lai Jianhui , Deng Changguang , Feng Junli , Liu Min , Zhou Kesong
Published: March 2021

Advanced aero-engine is a key technique that is used all over the world, where many high-temperature components such as turbine blades and combustor, are made of Ni/Co/Fe based superalloys. However, they need high-temperature protection to avoid fast performance degradation. Generally, the superalloy high-temperature components are protected by thermal barrier coatings (TBCs) obtained via an atmospheric plasma spray (APS) and an electron beam-physical vapor deposition (EB-PVD). Here, a novel 3rd generation TBCs process using plasma spray-physical vapor deposition (PS-PVD) is presented, showing a more promising use than the traditional APS and EB-PVD. The PS-PVD feature uses evaporating ceramic powder, which results in the deposition of a feather-like columnar coating. This special microstructure showed good strain tolerance and non-line-of-sight (NLOS) deposition, giving great potential for application. In a working aero-engine, the high-temperature components face a serious environment, where foreign particle erosion is a great challenge and is the first barrier to the application of PS-PVD TBCs. As a solution, an Al-modification approach was proposed in this investigation. The results demonstrate that this approach can improve particle erosion resistance. Also, the thermal cycle performance had an apparent optimization.
Association Between Service Scope of Primary Care Facilities and Patient Outcomes: A Retrospective Study in China
Authors: Li Zhong , Shi Meng , He Ruibo , Zhang Mei , Zhang Chi , Xiong Xinyu , Zhang Liang , Li Boyang
Published: March 2021

Background: Extending the service scope of primary care facilities (PCFs) has been widely concerned in China. However, no current data about the association between service scope of PCFs with patient outcomes are available. This study aims to investigate the association between service scope of PCFs and patient outcomes. Methods: We first sampled four counties randomly from rural Guizhou, China. Claim data of 299,633 inpatient cases covered by 64 PCFs were derived from the local information system of New Rural Cooperation Medical Scheme. The service scope of PCFs was collected with self-administrated questionnaires. Primary outcomes were 1) level of inpatient institutions, 2) length of stay, 3) per capita total health cost, 4) per capita out-of-pocket cost, 5) reimbursement ratio, 6) 30-day readmission. A total of 64 PCFs were categorized into five groups per facility-level service scope scores. Generalized linear regression models, logistic regression model, and ordered regression model were conducted to identify the association between service scope of PCFs and patient outcomes. Results: On average, the median service scope score of PCFs was 20, with wide variation across PCFs. After controlling for demographic and clinical characteristics, patients living in communities with PCFs of greatest service scope (Quintile V vs. I) tended to have smaller rates of admission by county-level hospitals (-6.2% [-6.5%, -5.9%], city-level hospitals (-1.9% [-2.0%, -1.8%]), and provincial hospitals (-2.1% [-2.2%, -2.0%]), smaller rate of 30-day readmission (-0.5% [-0.7%, -0.3%]), less total health cost (-201.8 [-257.9, -145.8]) and out-of-pocket cost (-210.2 [-237.2, -183.2]), and greater reimbursement ratio (2.3% [1.9%, 2.8%]) than their counterparts from communities with PCFs of least service scope.Conclusion: The service scope of PCFs varied a lot in rural Guizhou, China. PCFs' greater service scope was associated with a reduction in secondary and tertiary hospital admission, reduced total cost and out-of-pocket cost, and 30-day readmission and increased reimbursement ratio. These results raised concerns about access to care for patients discharged from hospitals, which suggests potential opportunities for cost savings and improvement of quality of care. However, further evidence is warranted to investigate whether extending the service scope of PCFs is cost-effective and sustainable.
Transcriptomic Nnalysis Reveals the Mechanism of Host Growth Promotion by Endophytic Fungus of Rumex Gmelinii Turcz.
Authors: Changhong Ding , Wang Shouyu , Li Jiabin , Wang Zhenyue
Published: March 2021

Rumex gmelinii Turcz. (RGT) is a medicinal plant of Rumex in Polygonaceae. Our research group isolated an endophytic fungus plectosaphaerella cucumerina (Strain J-G) from RGT, which could promote the growth of the host significantly when was co-cultured with the host. In this study, we mainly used transcriptomic analysis to explore the molecular mechanism of the growth promoting effect. It was found that during the process of co-culture with Strain J-G, metabolism of amino acids, the synthesis and metabolism of carbohydrates in RGT tissue culture seedlings were all promoted, which provided sufficient material and energy basis for the growth of plants. In addition, response to hormones such as auxin and cytokinin in RGT tissue culture seedlings was improved significantly, which promoted the growth and development of plants. The repairing ability of DNA in RGT tissue culture seedlings was also enhanced to provide a good guarantee for the growth of plants. Meanwhile, defense system of RGT tissue culture seedlings was also mobilized by the existence of Strain J-G, therefore more secondary metabolites and stress resistant substances were produced to ensure the normal growth and metabolism of plants.
Identification of molecular markers associated with diagnosis and prognosis in lung adenocarcinoma by bioinformatics analysis
Authors: Wei Zimeng , Zang Linnan , Zhao Min
Published: March 2021

Background: Lung adenocarcinoma (LUAD) is the main histological subtype of lung cancer. However, the molecular mechanism underlying LUAD is not yet clearly defined, but elucidating this process in detail would be of great significance for clinical diagnosis and treatment.Methods: Gene expression profiles were retrieved from Gene Expression Omnibus database (GEO), and the common differentially expressed genes (DEGs) were identified by online GEO2R analysis tool. Subsequently, the enrichment analysis of function and signaling pathways of DEGs in LUAD were performed by gene ontology (GO) and The Kyoto Encyclopedia of Genes and Genomics (KEGG) analysis. The protein-protein interaction (PPI) networks of the DEGs were established through the Search Tool for the Retrieval of Interacting Genes (STRING) database and hub genes were screened by plug-in CytoHubba in Cytoscape. Afterwards, the miRNAs and the hub genes network was constructed via miRWalk. Finally, receiver operating characteristic (ROC) curve and Kaplan-Meier plotter were performed to analyze the diagnosis and prognosis efficacy of hub genes.Results: A total of 312 DEGs were identified, including 74 up-regulated and 238 down-regulated genes. GO analysis results showed that DEGs were mainly enriched in biological processes including composition of extracellular matrix, regulation of angiogenesis and so on. KEGG analysis results revealed DEGs were mainly enrolled in cell adhesion signaling pathway. Subsequently, 10 hub genes, CDC20, CENPF, TPX2, TOP2A, KIAA0101, CDCA7, ASPM, ECT2, UBE2T and COL1A1, were identified. And TOP2A, CDCA7, TPX2 and COL1A1 showed strong relationships with each other and the miRNAs nearby in miRNAs-mRNA network obtained by miRWalk website. Finally, all these 10 hub genes were found significantly related to the diagnosis and prognosis of LUAD (p<0.05). Conclusions: Our results suggested that TOP2A, CDCA7, TPX2 and COL1A1 might present predictive value for the development and prognosis in LUAD, and might be used as potential molecular markers for the diagnosis and treatment of LUAD.
EVLİ KADINLARIN BENLİK SAYGISI, TEMEL KİŞİLİK ÖZELLİKLERİ İLE MARUZ KALDIKLARI AİLE İÇİ ŞİDDET ARASINDAKİ İLİŞKİNİN İNCELENMESİ
Authors: BAŞER Doğa , DÖĞÜCÜ Meliha
Published: March 2021

Bu araştırmanın amacı evli kadınların benlik saygı düzeyleri, temel kişilik özellikleri ve maruz kaldıkları aile içi şiddet arasındaki ilişkinin incelenmesidir. Bu çalışma nicel verilere dayalı tarama modelinde bir araştırmadır. Araştırma verileri, Ağustos-Aralık 2018 tarihleri arasında, kartopu örnekleme alma yöntemi kullanılarak ulaşılan 441 evli kadına araştırmacı tarafından oluşturulan tanıtıcı özellikler soru formu, Rosenberg Benlik Saygısı Ölçeği, Türk Kültüründe Geliştirilmiş Temel Kişilik Özellikleri Ölçeği ve Aile İçi Kadına Yönelik Şiddet Ölçeği uygulanarak toplanmıştır. Bu araştırmada evli kadınların Benlik Saygısı Ölçeği puan ortalamaları ile Aile İçi Kadına Yönelik Şiddet Ölçeği puan ortalamaları arasında negatif, zayıf, istatistiksel açıdan anlamlı bir ilişki olduğu, eş şiddeti arttıkça kadınların benlik saygı düzeylerinde azalma olduğu saptanmıştır. Aile İçi Kadına Yönelik Şiddet Ölçeği puan ortalamasının 25 yaş altı kadınlarda diğer yaş gruplarına göre daha fazla olduğu, kadınların eğitim ve ailenin gelir düzeyi yükseldikçe Aile İçi Kadına Yönelik Şiddet Ölçeği puan ortalamasının azaldığı, kadınların Benlik Saygısı Ölçeği, Aile İçi Kadına Yönelik Şiddet Ölçeği ve Temel Kişilik Özellikleri Ölçeği puan ortalamaları ile eşlerinin eğitim düzeyleri, evlenme biçimleri ve nikâh şekilleri arasında ise anlamlı bir ilişki olmadığı bulunmuştur. Bu çalışmadan elde edilen sonuçların ve sonuca bağlı olarak belirlenecek tespitlerin sosyal hizmetler perspektifinden kadın refahı alanına katkı sağlayacağı düşünülmektedir.
AN INVESTIGATION OF SYRIAN ASYLUM SEEKERS’ ATTITUDES TOWARD THEIR SITUATION IN TURKEY
Authors: KABAKLI ÇİMEN Latife , ERSOY QUADİR Seher
Published: March 2021

Syrians began to take refuge in Turkey on 29 April 2011 due to the civil war started in their country and their number in Turkey reached over 3.5 million by the year 2019 (Refugees Association, July 29, 2019). This study was conducted to examine the attitude of Turkey regarding Syrian asylum seekers. The sample group consisted of 233 Syrian people who were residing in two cities in different conditions in Turkey in 2017. The sample was selected among the Syrian asylum seekers by cluster sampling method. Research data were obtained using "Syrian Asylum Seekers’ Attitude towards Turkey Scale" developed by the authors. The relationship between this scale and demographic characteristics of the sample group was analyzed by calculating Pearson Correlation Coefficient. In findings sample group has a positive opinion about Turkey in general. But who are living in asylum seeker camps in Osmaniye have more satisfaction as an asylum seekers than those who are residents in Istanbul with their own facilities and limited state aid. Overall asylum seekers don’t participate that the problems caused by the Syrians in Turkey. Especially, those who living in Istanbul, who have a high level of education and who are responsible from less people were more opposed this idea.
ÜNİVERSİTE ÇALIŞANLARININ KORUYUCU AİLE UYGULAMASINA BAKIŞ AÇISI: BİR DURUM ÇALIŞMASI
Authors: ÖZAYDIN-DEMİRBAŞ Elif , İMİR Hatice Merve , KILINÇ Fatma Elif , BEKTAŞ Nursel
Published: March 2021

Koruyucu aile, çeşitli nedenlerle kendi ailesi tarafından bakım ve gözetimi sağlanamayan çocukların kısa veya uzun süreli bakımlarını devlet denetiminde üstlenen ve onları yetiştiren aileleri ifade etmektedir. Bu araştırmada koruyucu aile uygulamasının bilinirliği ve bu uygulamaya yönelik görüşlerin incelenmesi amaçlanmıştır. Bu kapsamda, üniversite çalışanlarının konuyla ilgili görüşleri nitel araştırma desenlerinden durum çalışması ile incelenmiştir. Veri toplama aracı olarak yarı-yapılandırılmış görüşme formu uygulanmıştır. Araştırma verileri içerik analizi ile değerlendirilmiştir. Araştırma sonucunda, katılımcıların bu uygulamadan pek haberdar olmadıkları, koruyucu aileliği evlat edinme veya bir çocuğu misafir etme gibi durumlarla karıştırdıkları görülmüştür. Aile odaklı hizmetlerin kuruluş bakımına göre daha verimli olduğuna dikkat çeken araştırmalar bulunmasına ve ülkemizde de aile odaklı hizmet modellerine öncelik verilmesine rağmen, bazı katılımcılar koruyucu aile yanında bakımın muhtemel dezavantaj ve riskleri bulunduğuna inanmaktadırlar ve bu nedenle devlet kontrolündeki kuruluş bakımının (çocuk evleri, çocuk evleri sitesi vb.) daha iyi bir seçenek olduğunu ifade etmişlerdir. Katılımcıların koruyucu aile ile ilgili endişelerinin başında korunmaya ihtiyaç duyan çocuklarla ilgili olumsuz düşünceleri yatmaktadır. Diğer taraftan, çocukları topluma kazandırma arzusu, onlara karşı hissedilen merhamet ve empati duyguları ve çocuk sahibi olamama/olmama gibi durumların katılımcıları koruyucu aile olmak hususunda motive edici faktörler olduğu belirlenmiştir. Sonuç olarak, katılımcıların genel olarak sahip oldukları eksik ve yanlış bilgiler göz önünde bulundurulduğunda, koruyucu aile uygulamasına yönelik bilinçlendirme çalışmalarının yapılmasının önemli olduğu düşünülmektedir.
Energy Dissipation in Frame Structures using Sliding Lever Mechanism Technique
Authors: Rizwan Muhammad , Fahad Muhammad , Naeem Muhammad , Adil Mohammad
Published: March 2021

Aim:

The aim of this study was to investigate the seismic energy dissipation mechanism of a novel and newly proposed sliding lever damping energy dissipation through dynamic shake table testing.

Background:

Typical energy dissipation systems consist of brace members and installed dampers, which are directly connected to structural members such as beams, columns and joint regions. This can cause additional load concentrations and may require retrofitting or strengthening of existing structures. In order to avoid the load demand on the main structural system, a new energy dissipation technique based on a sliding lever mechanism is proposed and tested through dynamic testing.

Objective:

The objective of this study was to test a new sliding lever damping energy dissipation through dynamic shake table testing within the scope of steel frame structures.

Methods:

In order to investigate the proposed energy dissipation configuration, a 1/3rd reduced scaled, three-story and one bay steel frame model has been fabricated and tested in a uni-directional shaking with increasing excitation and, without and with the new technique. For the sliding lever energy dissipation configuration, a non-structural frame (i.e., carrying no gravity loads) has been constructed and provided with an installed ramp-damper assembly. The shaking responses in the form of acceleration and displacement histories have been obtained during the experimental program and compared in order to check the efficiency of the proposed configuration.

Results:

The results showed a reduction of 55% to 6% in stories deflections and 36% to 12% in acceleration with the newly proposed sliding lever mechanism energy dissipation technique. The top story peak displacements for the damped frame case decreased by 36.55% in case of 0.1 g, 37.95% in case of 0.2g, 31.89% in case of 0.3g, 38.05% in case of 0.4g, 29.37% in case of 0.5g and 12.06% in case of 0.6g shaking excitation.

Conclusion:

It has been confirmed from the current experimental studies that the new configuration was quite effective in reducing the overall displacement and acceleration response. The reduction in the structural response parameters was very significant during low excitation shaking, whereas, with the increase in shaking intensities, the responses varied with much less difference.
The correlation between students' curiosity and generic science skills in science learning
Authors: Herianto Herianto , Wilujeng Insih
Published: March 2021

Curiosity is an attitude and action that seeks to know more deeply and broadly from something learned and acts as a driving force for learning. Generic science skills are thinking skills in intellectual abilities resulting from a combination of scientific knowledge and skills based on scientific knowledge. The purpose of this study was to determine the correlation between curiosity and students' generic science skills in science learning. This study uses a quantitative approach to explore the correlation between the variables studied. The total sample was 64 junior high school students, who were selected by random cluster sampling. Measurement of students' curiosity was carried out using a questionnaire, while generic science skills used multiple-choice test questions. The data obtained were then analyzed using simple linear regression on SPSS to determine the correlation between the two variables. The results showed that curiosity correlated with students' generic science skills (R = .389), with the category “low positive correlation.” The effect of curiosity on generic science skills is 15.1%, while other variables influence the rest.
Fuzzy soft set theory applied to commutative ideals of BCK-algebras
Authors:   Department of Mathematics, University of Tabuk, Tabuk, Saudi Arabia, et al. Muhiuddin
Published: March 2021

In the present paper, we apply the fuzzy soft set theory to commutative ideals of BCK-algebras. In fact, the notion of fuzzy soft commutative ideals over BCK-algebras is introduced, and related properties are investigated. Relations between fuzzy soft ideals and fuzzy soft commutative ideals are discussed, and conditions for a fuzzy soft ideal to be a fuzzy soft commutative ideal are provided. The “AND” operation, “extended intersection” and “union” of fuzzy soft (commutative) ideals are studied. Furthermore, characterizations of fuzzy soft (commutative) ideals are considered.
Development of a Resource Guide to Support the Engagement of Mental Health Providers and Patients With Digital Health Tools: Multimethod Study
Authors: Strudwick Gillian , McLay David , Lo Brian , Shin Hwayeon Danielle , Currie Leanne , Thomson Nicole , Maillet Éric , Strong Vanessa , Miller Alanna , Shen Nelson , Campbell Janis
Published: March 2021

Background

As mental illness continues to affect 1 in 5 individuals, and the need for support has increased during the COVID-19 pandemic, the promise of digital mental health tools remains largely unrealized due to a lack of uptake by patients and providers. Currently, most efforts on supporting the uptake of digital mental health tools remain fragmented across organizations and geography. There is a critical need to synthesize these efforts in order to provide a coordinated strategy of supporting the adoption of digital mental health tools.

Objective

The specific aim of this project is to develop a web-based resource document to support the engagement of mental health providers and patients in the use of digital mental health tools.

Methods

The web-based resource was developed using a multimethod approach. A grey literature review was conducted in 2019 to identify relevant toolkits that are available in the public domain. This was supplemented with an environmental scan where individuals with expertise in the development, acquisition, implementation, and evaluation of digital mental health tools were invited to contribute additional tools or documents not identified in the grey literature search. An engagement workshop was held with stakeholders to explore how the resource document should be developed and delivered. These findings were collectively used to develop the final iteration of the resource document.

Results

Based on a gray literature review and environmental scan with 27 experts, 25 resources were identified and included in the resource guide. These resources were developed for patients and providers by organizations from 5 countries. An engagement workshop was held with 14 stakeholders, and barriers related to cultural sensitivity, sustainability, and accessibility of the toolkit were identified. The final iteration of the resource document was developed by the research team using findings from the gray literature review, environmental scan, and engagement workshop. The contents of the 45-page resource guide are directed at mental health care providers, administrators, and patients (inclusive of families and caregivers).

Conclusions

The use of a multimethod approach led to the development of a resource guide that builds on existing evidence on digital mental health tools and was co-designed with stakeholders and end-users. The resource guide is now publicly available online for free and is being promoted through digital health and mental health websites. Future work should explore how this document can be integrated into clinical care delivery and pathways.
Desain dan Simulasi Dual Input Single Output Buck Converter dengan Kontrol Fuzzy
Authors: Wachid Abdul Rahman , Wahjono Endro , Nugraha Syechu Dwitya Nugraha
Published: March 2021

Dalam makalah ini didesain dan disimulasikan dual input single output buck converter dengan kontrol fuzzy untuk suplai beban DC dengan menggunakan software PSIM. Dual input single output converter dapat bekerja dengan dua sumber yang berbeda. Penggunaan dua sumber dari panel surya dan turbin angin adalah cara alternatif untuk mendapatkan nilai daya output yang lebih besar untuk suplai beban DC. Sumber dari panel surya dan turbin angin akan masuk ke dalam sistem rangkaian dual input buck converter secara bersamaan dengan kondisi sumber terpasang secara seri. Agar kedua sumber dapat bekerja secara bersamaan, duty cycle diatur menggunakan kontrol fuzzy sehingga tegangan output sesuai dengan yang diinginkan. Simulasi dilakukan dengan kondisi panel surya yang memiliki nilai iradiasi dan temperatur berubah-ubah serta turbin angin yang juga terkena angin dengan kecepatan tidak tetap, yaitu antara 4-8 m/s. Hasil simulasi menunjukkan bahwa dual input single output buck converter dapat bekerja dalam keadaan disuplai oleh dua sumber yang berbeda dengan tegangan output converter yang stabil di set point, yaitu 14,4 volt.
Teknik Pengujian Kinerja Algoritme Relay Jarak Menggunakan DIgSILENT
Authors: Rohadi Nanang , Nendi Suhendi  , Liu Kin Men
Published: March 2021

Makalah ini menyajikan teknik orisinal pengujian untuk mengevaluasi kinerja algoritme relay proteksi saluran transmisi (relay jarak model SEL-421) menggunakan DIgSILENT. Tujuan yang diharapkan dari publikasi ini adalah untuk memberikan pemahaman tentang penggunakan software DIgSILENT untuk pengujian relay proteksi. Akurasi dari algoritme pengukuran impedans kegagalan yang diakibatkan oleh pengaruh faktor ketidakpastian sistem dapat diamati secara bersamaan dan dilakukan pengujian secara otomatis. Misalnya, pengaruh dari resistans kegagalan dan sudut aliran daya adalah dianggap sebagai faktor ketidakpastian. Pada metode pengujian yang ditawarkan, simulasi gangguan pada saluran transmisi dilakukan pada sejumlah lokasi gangguan yang berbeda dengan perubahan nilai dari parameter ketidakpastian berdasarkan nilai sampel parameter dan diubah secara serentak untuk melihat pengaruh terhadap kinerja relay. Sampel parameter ketidakpastian yang digunakan dibangkitkan secara acak pada rentang nilai tertentu. Pengujian otomatis telah diaplikasikan melalui algoritme yang dikembangkan dengan DIgSILENT Programming Language (DPL) pada DIgSILENT. Contoh yang disajikan pada publikasi ini menjelaskan tentang metode pengujian yang ditawarkan dapat juga digunakan untuk mendemontrasikan kegunaannya secara praktis. Pada makalah ini, metode untuk pengujian relay jarak telah berhasil diimplementasikan melalui kombinasi software DIgSILENT dan MATLAB.
Model Rangkaian-T Pembangkit Listrik Tenaga Bayu untuk Analisis Aliran Daya Tiga-Fase
Authors: Gianto Rudy
Published: March 2021

Akhir-akhir ini, penetrasi Pembangkit Listrik Tenaga Bayu (PLTB) pada sistem distribusi tenaga listrik mengalami peningkatan yang cukup signifikan. Penetrasi PLTB ini dapat memengaruhi kondisi keadaan mantap dan dinamik sistem tersebut. Lebih lanjut, sistem distribusi tenaga listrik biasanya tidak seimbang, sehingga harus dianalisis secara tiga-fase. Oleh karena itu, agar kondisi-kondisi sistem dapat dievaluasi dengan baik, pembentukan model tiga-fase dari komponen-komponen sistem (termasuk PLTB) merupakan hal yang sangat penting. Makalah ini mengusulkan metode sederhana dalam memodelkan dan mengintegrasikan PLTB kecepatan tetap untuk analisis keadaan mantap (atau analisis aliran daya) sistem distribusi tiga-fase. Metode yang diusulkan tersebut didasarkan pada model rangkaian-T yang sebelumnya telah berhasil diaplikasikan pada sistem fase-tunggal. Pada makalah ini, model rangkaian-T fase-tunggal tersebut dimodifikasi dan diperluas sehingga dapat memfasilitasi analisis aliran daya tiga-fase pada kondisi sistem tak-seimbang. Aplikasi usulan model pada dua sistem distribusi tiga-fase, yaitu sistem 33-simpul dan 25 simpul, juga diselidiki dan disajikan pada makalah ini. Hasil-hasil penyelidikan yang dilakukan pada sistem tersebut memperlihatkan bahwa metode yang diusulkan valid dan akurat.
Implementasi Algoritme Support Vector Machines untuk Klasifikasi Area Terbakar di Lahan Gambut
Authors: Edi Saputra  , Ulfa Khaira  , Zainil Abidin
Published: March 2021

Kebakaran hutan telah menjadi bencana tahunan di Indonesia, yang berdampak pada degradasi lahan. Kebakaran hutan banyak terjadi di lahan gambut. Pada bulan Agustus 2019 terdeteksi sebanyak 810 hotspot di Provinsi Jambi. Informasi luas area kebakaran diperlukan untuk menentukan kebijakan dalam pengelolaan hutan dan lahan. Informasi mengenai luas area kebakaran sulit didapatkan dari pengukuran lapangan karena area yang luas dan tidak mudah diakses. Data Landsat merupakan salah satu jenis citra dari teknologi remote sensing yang dapat digunakan untuk memetakan luas area kebakaran. Salah satu metode yang sering digunakan untuk mengestimasi luas area kebakaran adalah dengan teknik interpretasi visual on screen. Namun, teknik ini memerlukan tenaga interpreter yang berpengalaman. Untuk itu, pada makalah ini digunakan teknik interpretasi digital menggunakan algoritme Support Vector Machine (SVM) untuk mengklasifikasikan area kebakaran di Kabupaten Muaro Jambi pada ekosistem gambut indikatif fungsi lindung, kemudian menghitung estimasi luasan lahan vegetasi, lahan terbuka, dan area terbakar. Makalah ini menghasilkan klasifikasi dengan akurasi sebesar 99,8%. Estimasi luas gambut berdasarkan klasifikasi SVM pada tanggal 15 Agustus 2019 adalah 1.396,89 ha teridentifikasi sebagai area terbakar, 7.069,5 ha adalah area vegetasi, dan 1.089,54 ha merupakan area lahan terbuka.