bluuebunny/crossref_metadata_2025 huggingface dataset:
Associations of HLA Polymorphisms with Chronic Kidney Disease in Japanese Rheumatoid Arthritis Patients
Authors: Higuchi Takashi , Oka Shomi , Furukawa Hiroshi , Shimada Kota , Hashimoto Atsushi , Komiya Akiko , Matsui Toshihiro , Fukui Naoshi , Tohma Shigeto
Published: July 2023

Objectives: The prevalence of chronic kidney disease (CKD) was reported to be higher in rheumatoid arthritis (RA) patients than in normal healthy individuals. Human leukocyte antigen (HLA) was associated with RA or CKD. Few studies on the association of HLA with CKD in RA have been reported. Here, we investigated the association of HLA polymorphisms with CKD in Japanese RA patients. Methods: HLA-DRB1 genotyping was conducted in 351 Japanese RA patients with CKD (estimated glomerular filtration rate [eGFR] lower than 60 [mL/min/1.73 m2]) and 959 without CKD (eGFR equal to or higher than 60 [mL/min/1.73 m2]). Associations of allele carrier frequencies of DRB1 with CKD were examined in the RA patients. Results: There was an association of DRB1*13:02 with CKD in RA, but this did not achieve statistical significance (p = 0.0265, odds ratio [OR] 1.70, pc = 0.7412, 95% confidence interval [CI] 1.09–2.64). The DR6 serological group was associated with CKD in RA (p = 0.0008, OR 1.65, 95% CI 1.24–2.20). A gene-dosage effect of DR6 was not detected. Logistic regression analysis showed that the association of DR6 with CKD in RA was independent of clinical characteristics. Conclusions: The present study first revealed the independent predisposing association of DR6 with CKD in Japanese RA patients, although DR6 is known to be protective against RA. Our data suggest direct or indirect roles of HLA for the development of CKD in RA, but the mechanisms are not clear.
Bari Shoulder Telemedicine Examination Protocol (B-STEP): A Standard Protocol for Personalized Remote Shoulder Examination
Authors: Moretti Lorenzo , Bizzoca Davide , Farì Giacomo , Caricato Alessandro , Angiulli Francesco , Cassano Giuseppe Danilo , Solarino Giuseppe , Moretti Biagio
Published: July 2023

The COVID-19 pandemic drastically changed many aspects of the traditional functioning of health systems all around the world. In Italy, as reported by the CIO, compared to the previous year, there was a significant reduction in 2020 in overall outpatient activities by up to 75%. These data support the need for telemedicine, which represents a current challenge and can no longer be postponed in the future. This study aims to elaborate on a possible model for remote shoulder examination based on traditional tests to improve the quality of telemedicine in orthopedic and rehabilitation. Between May 2020 and November 2020, ten orthopedic surgeons individually examined six patients with a known shoulder disorder, both in hospital and via webcam according to the previously shared protocol (B-STEP). According to the 10 observers, completing 100% of the ASES score and at least 87.5% of the Constant score is possible. Shoulder ROM and many specific tests are also reproducible via webcam, but with less sensitivity, according to the subjective opinion of observers. The B-STEP is a useful protocol for the standardization of the objective examination of the shoulder via webcam. Further studies are necessary to determine if the B-STEP protocol is useful for diagnosing pathology in unknown patients and evaluating its sensitivity and specificity for each pathology.
4-(2,5-Dimethyl-1H-pyrrol-1-yl)-1,2,5-oxadiazol-3-amine
Authors: Obruchnikova Natalia V. , Rakitin Oleg A.
Published: July 2023

1,2,5-Oxadiazol-3-amines with a heterocyclic substituent in the 4-position are being intensively investigated as compounds with valuable pharmacological activity. In this communication, the reaction of 1,2,5-oxadiazole-3,4-diamine with 2,5-hexanedione was shown to selectively give 4-(2,5-dimethyl-1H-pyrrol-1-yl)-1,2,5-oxadiazol-3-amine as a product of the Paal–Knorr reaction. The structure of the synthesized compound was established by elemental analysis, high-resolution mass spectrometry, 1H and 13C NMR, and IR spectroscopy.
Jarosites: Structure, Formation, Leaching, Environmental, and Applications
Authors: Cruells Montserrat , Roca Antoni
Published: July 2023

Jarosite, beudantite, and alunite are members of the alunite supergroup [...]
Dealloyed Nanoporous Gold-Based Materials for Energy Storage and Conversion
Authors: Yu Mengdan , Wu Xiaoyu , Qin Chunling , Wang Zhifeng
Published: July 2023

The unique bicontinuous porous structure and superior electrical conductivity of nanoporous gold (NPG) make it a highly promising material for energy storage and conversion. Although the number of articles on the study of NPG-based materials in energy fields has increased significantly in recent years, the collation and review of these articles are still lacking. Herein, we address this gap by reviewing recent research activities on dealloyed NPG for energy storage and conversion applications. Firstly, the typical dealloying process for forming NPG is introduced. Subsequently, NPG-based composite catalysts used to catalyze water splitting and fuel cells electrode reactions are presented. Afterward, the applications of NPG for different types of electrodes of supercapacitors (SCs) and batteries are discussed. Finally, the studies on NPG for catalyzing CO2 reduction reaction (CO2RR) are reviewed. In a word, the recent research progress of NPG-based materials is reviewed and the future research directions are outlined, laying the cornerstone for the preparation of more advanced energy storage and conversion devices in the future.
Metabolites of Life: Phosphate
Authors: Błaszczyk Janusz Wiesław
Published: July 2023

The process of aging and escalating the failure of all body organs has become the center of interest in contemporary science and medicine. The leading role of phosphate-calcium tandem deficiency as a pacemaker of metabolic senescence has emerged recently. Most of the phosphates in the human body are stored in the bones, which seem to play a pivotal role in all metabolic and energetic processes. Bone metabolism combines physical activity with adaptive changes in the internal environment of the body, which is necessary for its survival. Phosphate-calcium signaling is the primary mechanism for controlling homeostasis and its recovery after exercise-induced disorders. Phosphates play an important role in the regulation of energy metabolism both by regulating postprandial glucose storage in the muscles and in the liver, as well as the distribution and adaptation of energy metabolites to the needs of the brain and skeletal muscles. The bone-driven energy metabolism is of decisive importance for maintaining all vital functions of the body organs, including their proper functioning and integrated interplay. The phosphate-calcium tandem contributes to the development and proper functioning of the organism, whereas energy dysmetabolism is the main cause of aging and the final termination of life.
Variation in Terpenoid and Flavonoid Content in Different Samples of Salvia semiatrata Collected from Oaxaca, Mexico, and Its Effects on Antinociceptive Activity
Authors: Ortiz-Mendoza Nancy , San Miguel-Chávez Rubén , Martínez-Gordillo Martha Juana , Basurto-Peña Francisco Alberto , Palma-Tenango Mariana , Aguirre-Hernández Eva
Published: July 2023

Salvia semiatrata Zucc. (Lamiaceae) is endemic to Oaxaca, Mexico, and is known for its analgesic properties. Terpenoids and phenolic compounds with antinociceptive potential have been characterised from this species. The aim of this research was to determine the variation in terpenoids and flavonoids in ethyl acetate extracts of S. semiatrata collected from ten different localities, as well as to evaluate the antinociceptive effect between plants with higher and lower contents of these secondary metabolites. Quantification of S. semiatrata compounds was performed via HPLC-DAD, whereas in vivo evaluation of the antinociceptive effect was performed via formalin test. The results showed that the most abundant groups of metabolites are oleanolic acid (89.60–59.20 µg/mg), quercetin (34.81–16.28 µg/mg), catechin (11.30–9.30 µg/mg), and 7-keto-neoclerodan-3,13-dien-18,19:15,16-diolide (7-keto) (8.01–4.76 µg/mg). Principal component and canonical correspondence analysis showed that the most contrasting localities in terms of compound content and climatic variables are Miahuatlán and Santiago Huauclilla. The differences in metabolite content between the two locations did not affect the antinociceptive effects evaluated at a dose of 300 mg/kg, p.o. In conclusion, the results indicate that S. semiatrata is effective in relieving pain, regardless of the site of collection, reinforcing its traditional use as analgesic.
Abundance and Genetic Significance of Lithium in Karst-Type Bauxite Deposits: A Comparative Review
Authors: Economou-Eliopoulos Maria , Kanellopoulos Christos
Published: July 2023

Palaeo weathering during the Cretaceous–Eocene interval is most favorable for bauxitization, i.e., transport and deposition in traps on the karstified surfaces of the Mediterranean karst bauxite belt, including the Parnassos–Ghiona bauxite deposit. Resources of lithium (Li), a critical metal of strategic significance in karst-type bauxite deposits, have attracted significant attention in recent years. Due to the discovery of the Li enrichment in certain karstic bauxite deposits in Europe and particularly in China, this review study is focused on the unexplored Li content in the Parnassos–Ghiona (Greece) bauxite deposit, aiming to improve the understanding of the major controlling factors for their origin and enrichment of critical metals. The presence of thin (up to 50 cm) pyrite-bearing coal seams and carbonaceous facies on top of the Parnassos–Ghiona bauxite deposit, at the transition between B3 (the youngest) bauxite horizon and the occurrence of multicolor bauxite ores reflecting a multistage evolution and changes in the mineralogy and geochemistry, is a common feature with other bauxite deposits in Europe and elsewhere. The organic matter, such as microorganisms in coal layers and carbonaceous layers (derived from plants and algae growing in paleo-mires after a regression of the sea), contains Li, which is derived from seawater, as suggested by a positive correlation with B (a seawater component as well). The available geological, mineralogical, and geochemical data highlight the particular significance of coal layers and carbonaceous layers overlying bauxite bodies as a driving force for redox reactions and as a source of Li in the exploration of karst-type bauxite deposits.
Time-Course of Transcriptomic Change in the Lungs of F344 Rats Repeatedly Exposed to a Multiwalled Carbon Nanotube in a 2-Year Test
Authors: Hojo Motoki , Maeno Ai , Sakamoto Yoshimitsu , Yamamoto Yukio , Taquahashi Yuhji , Hirose Akihiko , Suzuki Jin , Inomata Akiko , Nakae Dai
Published: July 2023

Despite intensive toxicological studies of carbon nanotubes (CNTs) over the last two decades, only a few studies have demonstrated their pulmonary carcinogenicities in chronic animal experiments, and the underlying molecular mechanisms are still unclear. To obtain molecular insights into CNT-induced lung carcinogenicity, we performed a transcriptomic analysis using a set of lung tissues collected from rats in a 2-year study, in which lung tumors were induced by repeated intratracheal instillations of a multiwalled carbon nanotube, MWNT-7. The RNA-seq-based transcriptome identified a large number of significantly differentially expressed genes at Year 0.5, Year 1, and Year 2. Ingenuity Pathway Analysis revealed that macrophage-elicited signaling pathways such as phagocytosis, acute phase response, and Toll-like receptor signaling were activated throughout the experimental period. At Year 2, cancer-related pathways including ERBB signaling and some axonal guidance signaling pathways such as EphB4 signaling were perturbed. qRT-PCR and immunohistochemistry indicated that several key molecules such as Osteopontin/Spp1, Hmox1, Mmp12, and ERBB2 were markedly altered and/or localized in the preneoplastic lesions, suggesting their participation in the induction of lung cancer. Our findings support a scenario of inflammation-induced carcinogenesis and contribute to a better understanding of the molecular mechanism of MWCNT carcinogenicity.
Design and Fabrication of an Ag Ultrathin Layer-Based Transparent Band Tunable Conductor and Its Thermal Stability
Authors: Hu Er-Tao , Zhao Hongzhi , Wang Min , Wang Jing , Cai Qing-Yuan , Yu Kehan , Wei Wei
Published: July 2023

Transparent conductors (TC) have been widely applied in a wide range of optoelectronic devices. Nevertheless, different transparent spectral bands are always needed for particular applications. In this work, indium tin oxide (ITO)-free TCs with tunable transparent bands based on the film structure of TiO2/Ag/AZO (Al-doped ZnO) were designed by the transfer matrix method and deposited by magnetron sputtering. The transparent spectra and figure-of-merit (FOM) were effectively adjusted by precisely controlling the Ag layer’s thickness. The fabricated as-deposited samples exhibited an average optical transmittance larger than 88.3% (400–700 nm), a sheet resistance lower than 7.7 Ω.sq−1, a low surface roughness of about 1.4 nm, and mechanical stability upon 1000 bending cycles. Moreover, the samples were able to hold optical and electrical properties after annealing at 300 °C for 60 min, but failed at 400 °C even for 30 min.
Graphene Hybrid Metasurfaces for Mid-Infrared Molecular Sensors
Authors: Yager Tom , Chikvaidze George , Wang Qin , Fu Ying
Published: July 2023

We integrated graphene with asymmetric metal metasurfaces and optimised the geometry dependent photoresponse towards optoelectronic molecular sensor devices. Through careful tuning and characterisation, combining finite-difference time-domain simulations, electron-beam lithography-based nanofabrication, and micro-Fourier transform infrared spectroscopy, we achieved precise control over the mid-infrared peak response wavelengths, transmittance, and reflectance. Our methods enabled simple, reproducible and targeted mid-infrared molecular sensing over a wide range of geometrical parameters. With ultimate minimization potential down to atomic thicknesses and a diverse range of complimentary nanomaterial combinations, we anticipate a high impact potential of these technologies for environmental monitoring, threat detection, and point of care diagnostics.
First-Principles Study of χ3-Borophene as a Candidate for Gas Sensing and the Removal of Harmful Gases
Authors: Duan Jia-Xing , Tian Yu-Ping , Wang Chao-Bo , Zhang Lian-Lian
Published: July 2023

The potential application of borophene as a sensing material for gas-sensing devices is investigated in this work. We utilize density functional theory (DFT) to systematically study the adsorption mechanism and sensing performance of χ3-borophene to search for high-sensitivity sensors for minor pollutant gases. We compare the results to those for two Pmmn borophenes. The first-principles calculations are used to analyze the sensing performance of the three different borophenes (2 Pmmn borophene, 8 Pmmn borophene, and χ3-borophene) on five leading harmful gases (CO, NH3, SO2, H2S, and NO2). The adsorption configuration, adsorption energy, and electronic properties of χ3-borophene are investigated. Our results indicate that the mechanism of adsorption on χ3-borophene is chemisorption for NO2 and physisorption for SO2 and H2S. The mode of adsorption of CO and NH3 on χ3-borophene can be both physisorption and chemisorption, depending on the initially selected sites. Analyses of the charge transfer and density of states show that χ3-borophene is selective toward the adsorption of harmful gases and that N and O atoms form covalent bonds when chemisorbed on the surface of χ3-borophene. An interesting phenomenon is that when 8 Pmmn borophene adsorbs SO2, the gas molecules are dismembered and strongly adsorb on the surface of 8 Pmmn borophene, which provides a way of generating O2 while adsorbing harmful substances. Overall, the results of this work demonstrate the potential applications of borophene as a sensing material for harmful gas sensing or removal.
Advanced In Vivo Prediction by Introducing Biphasic Dissolution Data into PBPK Models
Authors: Denninger Alexander , Becker Tim , Westedt Ulrich , Wagner Karl G.
Published: July 2023

Coupling biorelevant in vitro dissolution with in silico physiological-based pharmacokinetic (PBPK) tools represents a promising method to describe and predict the in vivo performance of drug candidates in formulation development including non-passive transport, prodrug activation, and first-pass metabolism. The objective of the present study was to assess the predictability of human pharmacokinetics by using biphasic dissolution results obtained with the previously established BiPHa+ assay and PBPK tools. For six commercial drug products, formulated by different enabling technologies, the respective organic partitioning profiles were processed with two PBPK in silico modeling tools, namely PK-Sim and GastroPlus®, similar to extended-release dissolution profiles. Thus, a mechanistic dissolution/precipitation model of the assessed drug products was not required. The developed elimination/distribution models were used to simulate the pharmacokinetics of the evaluated drug products and compared with available human data. In essence, an in vitro to in vivo extrapolation (IVIVE) was successfully developed. Organic partitioning profiles obtained from the BiPHa+ dissolution analysis enabled highly accurate predictions of the pharmacokinetic behavior of the investigated drug products. In addition, PBPK models of (pro-)drugs with pronounced first-pass metabolism enabled adjustment of the solely passive diffusion predicting organic partitioning profiles, and increased prediction accuracy further.
Assessing the Effect of Cellulose Nanocrystal Content on the Biodegradation Kinetics of Multiscale Polylactic Acid Composites under Controlled Thermophilic Composting Conditions
Authors: Colli-Gongora Priscila Esther , Moo-Tun Nora Magally , Herrera-Franco Pedro Jesús , Valadez-Gonzalez Alex
Published: July 2023

This work studied the effect of cellulose nanocrystal (NCC) content on the biodegradation kinetics of PLA-based multiscale cellulosic biocomposites (PLAMCBs). To facilitate biodegradation, the materials were subjected to thermo-oxidation before composting. Biodegradation was carried out for 180 days under controlled thermophilic composting conditions according to the ASTM D 5338 standard. A first-order model based on Monod’s kinetics under limiting substrate conditions was used to study the effect of cellulose nanocrystal (NCC) content on the biodegradation kinetics of multiscale composite materials. It was found that thermo-oxidation at 70 °C for 160 h increased the biodegradability of PLA. Also, it was found that the incorporation of cellulosic fibrous reinforcements increased the biodegradability of PLA by promoting hydrolysis during the first stage of composting. Likewise, it was found that partial substitution of micro cellulose (MFC) by cellulose nanocrystals (NCCs) increased the biodegradability of the biocomposite. This increase was more evident as the NCC content increased, which was attributed to the fact that the incorporation of cellulose nanocrystals facilitated the entry of water into the material and therefore promoted the hydrolytic degradation of the most recalcitrant fraction of PLA from the bulk and not only by surface erosion.
Orthodoxy and Ecumenical Dialogue after Crete Synod (2016) and Social Ethos Document (2020): History, Critical Positions and Reception
Authors: Marcu Doru
Published: July 2023

In this study, I will analyse the position of the Orthodox Church(es) towards the ecumenical dialogue in accordance with the documents approved by the Synod of Crete (2016), but also with the social document For the Life of the World of the Ecumenical Patriarchate (2020). After a brief presentation of the important moments of the historical journey for the meeting of the Synod, I will present the most important internal and reception issues of it. In the following, I will present the reason for the publication of the social document and the relation with the Synod of Crete. In the last part of the study, I will deal critically with a theological synthesis on the following topics: ecclesiological self-identity, Trinitarian baptism, the quality of being a Christian, the Orthodox Church and the Churches, ecumenism for dialogue, for witnessing, and cooperation. Of course, in the end, I will present the most important conclusions.
Improving Generation Y Volunteerism in Extension Programs
Authors: Andrews Kevin , Lockett Landry
Published: July 2023

Members of Generation Y have many positive attributes that make them attractive to Extension volunteer administrators as a potential source of labor. However, they think differently, have unique needs, require new management styles, and have less tolerance for unpleasant working conditions than previous generations. Additionally, they are engaged primarily through the use of technology. This article gives strategies for recruiting and managing this group of hard-working, self-assured, team-oriented, capable, and creative group of volunteers through technology and other means.
Change Is Inevitable: How Field Specialist Positions Can Help Meet the Challenge
Authors: Ellzey Nancy , Romich Eric , Civttolo David , Davis Greg
Published: July 2023

After nearly 100 years, Extension has achieved a great deal. However, shrinking budgets from our traditional funders require us to think of new ways to address the needs of tomorrow and target programs that demonstrate impact and outcomes today. The field specialist model enables Extension to better address specific critical issues, leverage talent and resources, and develop collaborative partnerships that foster non-traditional funding opportunities while complementing the work of the county-based educator. The field specialist position may very well be the driving force in the 21st century Extension model.
Assessing Program Impact with the Critical Incident Technique
Authors: O”Neil Barbara
Published: July 2023

The critical incident technique (CIT) is a qualitative research method where subjects are encouraged to tell personal stories that provide descriptive data. Researchers who use the CIT employ a structured methodology to encourage respondents to share their experiences regarding a particular topic. Incidents are considered effective/successful when something positive occurs and ineffective/unsuccessful when there are negative results. This article reviews characteristics of the CIT and describes its use to collect data about how library professionals made use of information provided during a series of Extension-led financial education classes.
ISSUES OF SELECTING A PHYSICAL THERAPY TECHNOLOGY IN ACUTE CEREBRAL CIRCULATION DISORDER IN PATIENTS WITH COMORBIDITIES AT THE FIRST REHABILITATION STAGE
Authors:   Surgut State University, Surgut, Russia, Скробова Е. А. , Арямкина О. Л. ,   Surgut State University, Surgut, Russia
Published: July 2023

The study aims to review an up-to-date state of the cardiovascular complications manifested as acute cerebral circulation disorders, as well as the issues of medical rehabilitation with physical therapy technologies for patients with concomitant metabolically associated pathology in acute stage. The review was based on the scientific publications and regulatory legal acts from eLIBRARY.RU, PubMed, and Google Scholar. The search depth was 20 years. Comorbidity and its role in etiopathogenesis and frequency of cardiovascular events in a form of acute cerebral circulation disorders, which caused along with ischemic disorder mortality in Russia and worldwide, was analyzed. The possibilities of physic therapy technologies application during the first medical rehabilitation stage were determined.
INFLUENCE OF ANESTHESIA TYPE ON THE BLOOD CIRCULATION IN RATS
Authors:   V. A. Negovsky Research Institute of General Reanimatology, Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russia, Дубенский А. Ю. , Рыжков И. А. ,   V. A. Negovsky Research Institute of General Reanimatology, Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russia, Лапин К. Н. ,   V. A. Negovsky Research Institute of General Reanimatology, Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russia, Цоколаева З. И. ,   V. A. Negovsky Research Institute of General Reanimatology, Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russia, Калабушев С. Н. ,   V. A. Negovsky Research Institute of General Reanimatology, Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russia, Варнакова Л. А. ,   V. A. Negovsky Research Institute of General Reanimatology, Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russia, Долгих В. Т. ,   V. A. Negovsky Research Institute of General Reanimatology, Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russia, Гречко А. В. ,   V. A. Negovsky Research Institute of General Reanimatology, Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russia
Published: July 2023

The study aims to detect the effects of non-inhaled anesthetics of two different types on the parameters of the central hemodynamics and microcirculation in an occlusive reactive hyperemia test in two groups of male Wistar rats weighting 400–500 g. The “ChH” group received 6 % chloral hydrate solution at a dose of 300 mg/kg intraperitoneally, while the “zol + xyl” group received 20 mg/kg of tiletamine/zolazepam (Zoletil 100, France) mixed with 5 mg/kg of xylazine (Xylanit, Russia) intraperitoneally. The following parameters were measured: blood pressure, average heart rate, duration of PQ, QRS, and QTc intervals according to the electrocardiography, cutaneous blood flow with laser Doppler flowmetry, arterial blood gas composition and acid-base state. The mean value of perfusion was recorded simultaneously with electrocardiography and blood pressure. The parameters of a post-occlusive reactive hyperemia were analyzed to conduct an occlusive reactive hyperemia test. Blood pressure was statistically significantly lower in “ChH” group than in “zol + xyl” group when analyzing the central hemodynamics parameters. The “ChH” group demonstrated higher maximum asodilation in reactive hyperemia (CVCmax) and time of its achievement (Tmax). Both types of anesthesia demonstrated compensated and subcompensated mixed acidosis and moderate arterial hypoxemia when comparing parameters of arterial blood gas composition and acid-base state in rats.
EFFECTS OF TRANSCRANIAL ELECTRICAL THERAPY ON SYSTEMIC INFLAMMATION IN A HIGH-FAT FRUCTOSE DIET
Authors:   Kuban State Medical University, Krasnodar, Russia, Чабанец Е. А. , Каде А. Х. ,   Kuban State Medical University, Krasnodar, Russia, Цымбалов О. В. ,   Kuban State Medical University, Krasnodar, Russia, Трофименко А. И. ,   Kuban State Medical University, Krasnodar, Russia,   Research Institute – S. V. Ochapovsky Regional Clinical Hospital No. 1, Krasnodar, Russia, Ким Г. Г. ,   St. Petersburg State Pediatric Medical University, Saint Petersburg, Russia
Published: July 2023

The study aims to conduct a transcranial electrical stimulation therapy trial in rats influencing the indicators of systemic inflammation dynamics and the percentage content of visceral adipose tissue in a highfat fructose diet. The study included 180 male outbred rats, which were randomly distributed into three groups: the first group had a standard diet; the second group received the high-fat fructose diet; and the third group received both transcranial electrical stimulation therapy and the high-fat fructose diet. Tumor necrosis factor-α, interleukin-15, and interleukin-19 concentrations were measured in blood serum. The percentage of visceral adipose tissue in relation to body weight was calculated. The percentage content of visceral adipose tissue and serum concentration of tumor necrosis factor-α were lower, and interleukin-19 was higher in rats that received transcranial electrical stimulation with a high-fat fructose diet in comparison to the second group, which did not undergo the stimulation. Interleukin-19 level in the blood serum of rats in the second group grew as the trial progressed, whereas the opposite occurred in the third group. There was an inverse relation between the predictive variables of transcranial electrical stimulation, interleukin-19, and the variable of tumor necrosis factor-α. The data obtained in the experiment may also indicate that interleukin-15 cannot be unequivocally considered as a key factor associated with a decrease in visceral adipose tissue content when introducing a high fructose and animal-based saturated fat diet to rats.
the Civil Law System's Compulsion of Paternalism in Medical Area
Authors: RYU Hwa-Sin
Published: July 2023

This study discusses how paternalism in ethics should be estimated legally by main issues, summary of decision, and reasoning of the Supreme Court Decision. This Decision delivers that the duty to protect a patient's life is prior to the duty to respect a patient's rights of self-determination.
According to the autonomy principle, patients have the right to determine whether they allow the medical professionals to treat their disease or not and the medical professionals must follow the patients' decision. But the concept of paternalism restricts the autonomy principle.
However, I assert that the medical professional is not liable for the patient's death when he or she rejects medical treatments(gastrolavage) strongly making a disturbance as this case. We should examine how serious the patient's rejection of medical treatments was and how difficult the medical professional's paternalistic intervention was. Although medical law is different from medical ethics, paternalism in medical area can be expected legally as far as a medical professional can overcome a patient's continuous and strong rejection.
So, this study reviews the relation between medical professional and patient, and lays stress on the limitation of paternalism in medical area.
Revising the Korean Bioethics and Biosafety Act:Should researchers be prohibited from donating oocytes?*
Authors: McGuire John Michael
Published: July 2023

Recent public investigations into the human embryonic stem cell research of Hwang Woo-Suk and his colleagues have brought to light a plethora of ethical problems associated with that research as well as numerous deficiencies in the existing legislation designed to prevent such problems, the Korean Bioethics and Biosafety Act (KBBA). In response to these revelations, the Korean National Bioethics Commission and the Korean Ministry of Health and Welfare are currently in the process of revising the KBBA to ensure that future stem cell research in Korea is carried out in an ethically responsible manner. In this paper I focus on one of the ethical problems raised by Hwang’s research: the issue of oocyte donations by junior researchers. I address the following two questions: 1) Did Hwang violate ethical guidelines in accepting oocyte donations from junior researchers? 2) Should the KBBA be revised to prohibit oocyte donations from junior researchers? With respect to the first question, I argue that, contrary to popular opinion, Hwang did not violate the Helsinki Declaration in accepting oocytes donations from junior researchers. In response to the second question, I argue that the KBBA should indeed be revised to prohibit junior researchers from donating oocytes for research in which they themselves are involved.
EFEKTIFITAS PENGUKURAN CAPABILITY LEVEL TATA KELOLA TEKNOLOGI INFORMASI MENGGUNAKAN KERANGKA KERJA COBIT 2019
Authors: Erlansari Aan , Amal Ikhlasul , Wijanarko Andang
Published: July 2023

Saat ini teknologi informasi memiliki peran yang sangat penting bagi suatu organisasi atau perusahaan untuk mencapai tujuannya. Dinas Komunikasi dan Informatika yang selanjutnya disebut Diskominfo adalah perangkat daerah yang menyelenggarakan urusan Pemerintahan Daerah di bidang komunikasi dan informatika, bidang persandian, dan bidang statistik. Saat ini pada Dinas Komunikasi dan Informatika Kabupaten “X” sudah menerapkan tata kelola teknologi informasi ditandai dengan sudah diterapkannya SPBE pada Pemerintah Daerah Kabupaten “X”, kemudian telah menggunakan aplikasi berbasis elektronik sesuai klasifikasi  e-government, dan penerapan Standard Operating Procedure (SOP) terkait kebijakan kebijakan tata kelola yang berlaku. Namun terdapat beberapa permasalahan pada Diskominfo Kabupaten “X”, yaitu masalah mengenai sumber daya manusia, aset dan pengawasan. Oleh karena itu perlu dilakukannya pengukuran capability level tata kelola TI yang Bertujuan untuk mengetahui tingkat kapabilitas dan memberikan rekomendasi tata kelola TI menggunakan kerangka kerja COBIT 2019. Berdasarkan hasil penilaian pada COBIT 2019, capability level tata kelola TI pada Diskominfo Kabupaten “X” berada pada level 1 yaitu Performed Process yang berarti proses yang diimplementasikan berhasil mencapai tujuannya. Agar tata kelola TI pada Diskominfo Kabupaten “X” dapat mencapai capability level yang diingkan yaitu di level 3 (Established Process), maka rekomendasi yang perlu dilakukan adalah mengoptimalkan SDM yang ada sekarang, dilibatkannya Diskominfo itu sendiri dalam mengelola SDM, membuat daftar prioritas untuk pemasangan dan pengembangan aplikasi berbasis elektronik, dan menetapkan Standard Operational Procedure yang berkaitan dengan target kinerja dan kesesuaian.
Economical Impact of Full Closure for Accelerated Bridge Construction and Conventional Staged Construction
Authors:   University of Illinois Urbana-Champaign, El-Rayes Khaled , El-Gohary Nora ,   University of Illinois Urbana-Champaign, Golparvar-Fard Mani ,   University of Illinois Urbana-Champaign, Ignacio Ernest-John ,   University of Illinois Urbana-Champaign, Helaly Hadil ,   University of Illinois Urbana-Champaign
Published: July 2023

Accelerated bridge construction (ABC) methods have been increasingly used in recent years to reduce the impact of construction operations on traffic and mobility. ABC methods, however, often require a higher initial cost, more planning, and additional design coordination. Several tools have been developed to assist decision-makers in the selection of conventional staged construction or ABC methods based on bridge characteristics and requirements. Most of these existing tools, however, are qualitative and depend on the subjective opinion of decision-makers/experts. Accordingly, there is a need for additional research to develop quantitative tools for generating reliable cost estimates for conventional and accelerated bridge construction methods. This report presents the findings of a research project funded by the Illinois Department of Transportation (IDOT) to develop a decision support tool (DST) that IDOT can use to estimate and compare the cost of all bridge construction methods, including conventional staged construction and ABC methods. This project has four objectives. The first objective is to develop a qualitative DST that can be used by IDOT planners and decision-makers to identify all feasible bridge construction methods for any bridge project based on its specific characteristics, requirements, and constraints. The second objective is to create a quantitative cost-estimating DST that can be used to accurately estimate construction, road user, maintenance and rehabilitation, and life cycle costs for all feasible construction methods including conventional and ABC methods. The third objective is to develop guidance for the user interface of the developed DST to explain how it can be used to compare and rank all feasible bridge construction methods based on their individual performance in design, construction, road user, and maintenance and rehabilitation costs. The fourth objective is to evaluate the performance and accuracy of the developed quantitative DST for estimating bridge costs.
APPLICATION OF SYSTEMIC CRYOTHERAPY IN COSMETOLOGY
Authors: Uriasz Justyna , Kikowski Łukasz
Published: July 2023

Aim: The aim of this study was to assess the use of whole-body cryotherapy in cosmetology.
Materials and Methods: Literature review was conducted based on the available PubMed bibliographic database from 2012 to 2022. Articles in Polish, English and Russian were included. Keywords such as whole-body cryotherapy, cryogenic chamber, and cryotherapy in cosmetology were used during the publication search.
Conclusions: Whole-body cryotherapy is safe for the skin and has minimal effect on changes in pH, moisture and oiliness. Cryotherapy in a cryo-chamber can be used as complimentary therapy for the treatment of skin dermatoses and can also be a non-invasive method of treating various types of hair loss. It can also be an alternative method of reducing body fat.
Proceso Penal Directo Frente al Derecho a la Defensa.
Authors: Ordóñez Escobar Luis Eduardo
Published: July 2023

En el presente artículo se analizó la violación de las garantías básicas del procesado, cuyo objetivo es determinar la vulneración del derecho a la defensa en el desarrollo del procedimiento directo, tomando en consideración que tres días antes de cumplirse el plazo previsto para el señalamiento de la audiencia de juicio, deben ser presentados por escrito los medios probatorios, además el juez que conoce y resuelve la calificación de flagrancia, es el mismo juez que resolverá dentro de la audiencia de juicio. En este procedimiento especial el juez califica la flagrancia en delitos tipificados con pena de hasta cinco años; y, en delitos contra la propiedad que no superen de treinta salarios básicos unificados del trabajador en general, excluyéndose de este procedimiento las infracciones contra la eficiente administración pública, delitos contra la inviolabilidad de la vida e integridad personal y contra la libertad personal con resultado de muerte, contra la integridad sexual y reproductiva, así como también en aquellos delitos de violencia contra la mujer o miembros del núcleo familiar. (Código Orgánico Integral Penal [COIP], 2014, Art. 640). En conjunto se observaron los principios procesales, debido proceso, derecho a la tutela judicial efectiva, delitos contra la tutela judicial efectiva. Se utilizó el método  deductivo, recurriendo a normativa, doctrina, jurisprudencia, etc.
Complicaciones cardiovasculares del sars cov – 2 en pacientes diabéticos
Authors: Buendia Gomez Andres Fernando , Araújo Rodríguez Robinson Antolín , Barrera Beltra Sebastian Salvador , Pérez Villalba Víctor Daniel , Rincon Molano Miguel Angel , Salgado Espitia Valentina , Fuentes De Oro Nacira , Garcia Romero Alvaro Guillermo , Pumarejo Martínez Merielen de Jesús
Published: July 2023

La pandemia por SARS-CoV-2 ha representado una emergencia sanitaria global en donde se han identificado una serie de factores de riesgo que se asocian frecuentemente con altas tasas de morbilidad, complicaciones y mortalidad. La hipertensión arterial, la diabetes mellitus y la enfermedad cerebrovascular han sido mencionadas de manera especial debido a la existencia de factores relacionados con la enfermedad que condicionan un aumento en la susceptibilidad frente al virus dada por una mayor unión celular, una disminución del aclaramiento viral, una alteración en la función de las células T y un estado de hiperinflamación que finalmente conllevan al aumento del riesgo de padecer una complicación e incluso la muerte. Por medio de este artículo se busca resaltar principalmente la presencia de complicaciones cardiovasculares en pacientes diabéticos diagnosticados con infección por COVID-19 con el fin de favorecer el entendimiento de la condición y fortalecer el establecimiento de intervenciones asistenciales direccionadas en el enfoque de atención primaria, mantenimiento de la salud y prevención de la enfermedad.
PENERAPAN ETIKA MANAJEMEN DAN TANGGUNG JAWAB SOSIAL PEGAWAI KANTOR OTORITAS PELABUHAN UTAMA TANJUNG PRIOK JAKARTA UTARA
Authors: Dorce Dora , Rukmana Febi Indriyanti , Delimasari Delimasari , Madiistriyatno Harries
Published: July 2023

Etika manajemen dan tanggung jawab sosial merupakan aspek yang sangat penting dilaksanakan dalam aktivitas sebuah organisasi/lembaga demi terjaminnya kelangsungan proses bisnis dan program kerja yang sedang dijalankan oleh organisasi/lembaga tersebut. Untuk itu, perlu adanya penelitian dan pembahasan terkait penerapan etika manajemen dan tanggung jawab sosial khususnya bagi Aparatur Sipil Negara (ASN) yang bekerja pada instansi pemerintah, baik tingkat pusat maupun daerah. Tujuan penelitian ini adalah mengetahui dan menganalisa penerapan etika manajemen dan tanggung jawab sosial pegawai Kantor Otoritas Pelabuhan Utama Tanjung Priok Jakarta Utara Kementerian Perhubungan RI. Penelitian ini menggunakan metode deskriptif kualitatif dengan mengumpulkan berbagai sumber informasi yang diperoleh dari studi literatur arsip dokumen/perjanjian/peraturan/dokumen lainnya yang ada di lokasi penelitian. Hasil penelitian menunjukan bahwa fungsi ASN sebagai pelaksana kebijakan publik, pelayan publik, perekat dan pemersatu bangsa erat kaitannya dengan etika manajemen ASN sebagaimana telah diatur dalam Peraturan Pemerintah RI Nomor 42 Tahun 2004 Tentang Pembinaan Jiwa Korps dan Kode Etik Pegawai Negeri Sipil (PNS), yang kemudian diapdosi dan diturunkan menjadi Peraturan Menteri Perhubungan RI Nomor 99 Tahun 2011 Tentang Kode Etik PNS/ASN di Lingkungan Kementerian Perhubungan RI. Pada pelaksanaannya, Kantor Otoritas Pelabuhan Utama Tanjung Priok Jakarta Utara dalam rangka meningkatkan kedisiplinan pegawainya, telah melaksanakan penerapan integritas kinerja pegawai yang salah satunya dinilai dari aspek kehadiran dan kedisiplinan kerja dengan menggunakan alat mesin biometrik dan presensi kehadiran. Kantor Otoritas Pelabuhan Utama Tanjung Priok Jakarta Utara telah menerapkan amanat Undang-Undang Nomor 25 Tahun 2009 Tentang Standar Pelayanan Publik dan Peraturan Menteri Pendayagunaan Aparatur Negara dan Reformasi Birokrasi RI Nomor 60 Tahun 2012 Tentang Pedoman Pembangunan Zona Integritas menuju Wilayah Bebas Korupsi (WBK) dan Wilayah Birokrasi Bersih dan Melayani (WBBM) melalui pencapaian target yang telah ditetapkan diantaranya : Pencapaian Sistem Manajemen Mutu ISO 9001-2015 dan Penetapan Pelayanan Publik yang senantiasa mengedepankan kepentingan pengguna jasa dan masyarakat secara luas.
IMPLEMENTASI POLMAS SEBAGAI PEMBERDAYAAN SDM POLRI DALAM RANGKA PENGAMANAN PEMILU TAHUN 2024 DEMI TERWUJUDNYA STABILITAS KEAMANAN DALAM NEGERI
Authors: Setiawan Iwan , Jayadi Rahmat , Saputro Aziz Purwo , P Vera Veronica , Saputra Muhammad Ali , Madiistriyatno Harries
Published: July 2023

Penelitian ini didasarkan pada implementasi Polmas yang masih jauh dari harapan sehingga sekalipun sudah banyak memberikan manfaat dan perubahan di tubuh Polri ke arah lebih baik, namun manfaatnya belum secara signifikan dirasakan oleh masyarakat. Dari berbagai analisa dan evaluasi yang dilakukan, salah satu titk lemah dalam implementasi Polmas saat ini terletak pada masih terbatasnya kualitas SDM Polri Petugas Polmas, terutama terhadap pemilikan kompetensi-kompetensi yang dipersyaratkan sebagai akibat belum optimalnya penerapan manajemen rekrutmen dan pelatihan yang dilaksanakan. Dampaknya, peran-peran Petugas Polmas sebagai anggota tim manajemen sekaligus pelaksana utama di lapangan, masih belum optimal. Kondisi ini menjadikan sistem kerja yang terbangun juga belum dapat diintegrasikan, dikoordinasikan, dan disinkronisasikan dengan baik, dan apabila hal ini berlanjut diprediksikan akan berdampak kepada tugas pengamanan dalam Pemilu 2024 maupun dalam rangka mewujudkan Kamdagri yang kondusif. SDM Polri Petugas Polmas merupakan ujung tombak sekaligus faktor kunci keberhasilan implementasi Polmas.Menyikapi permasalahan di atas, maka dalam rangka implementasi Polmas sehingga dapat terakselerasi dengan baik sehingga secara signifikan dapat berkontribusi terhadap Pengamanan Pemilu 2024 dalam rangka terwujudnya Kamdagri yang kondusif, pemberdayaan SDM Polri Petugas Polmas hendaknya dibangun melalui penerapan manajemen berbasis kompetensi, melalui visi : “Mewujudkan SDM Polri yang kapabel, kredibel, dan akuntabel dalam pelaksanaan tugas, fungsi, dan peranannya selaku Petugas Polmas”. Sesuai dengan akar permasalahan yang dihadapi, untuk mencapai visi tersebut perlu ditempuh melalui penerapan rekrutmen dan pelatihan yang berbasis kompetensi, serta melalui pengembangan iklim/budaya kerja baru mampu merangsang pengembangan diri petugas Polmas secara komprehensif, serta dilakukan melalui upaya-upaya khusus untuk dijadikan komitmen bersama   dan dilaksanakan secara konsisten, konsekuen, dan berkelanjutan.
जीवनी और महिला लेखनः छूटे पन्नो की उड़ान – एक समीक्षा
Authors: राठोड मीना , बनकर रमेशभाई
Published: July 2023

दलित साहित्य मनुष्य को मनुष्य के रुप में देखता है। जिसे हम दलित मनोवैज्ञानिक मुक्ति का साहित्य कहते है। हशिये के बहार पडा भारतीय दलित समाज आज आत्मसम्मान तथा बहिस्कृत जिंदगी से मुक्ति पाने का संघर्ष एवं अपने आत्मसम्मान की पहचान की लडाई लड़ रहा है। शोषण के प्रति विद्रोह भाव जगाना ही साहित्य कर्मियों का कर्तव्य है। दलित साहित्य का उद्देश्य दलित समाज में जागृति पैदा करके उनमें स्वाभिमान भरना है। वे चाहते है कि संपूर्ण समाज व्यवस्था को नष्ट करके समान समाज व्यवस्था का निर्माण हो, नवीन समाज व्यवस्था निर्मित हो वहाँ हरेक व्यक्ति को समान अधिकार मिले।
Regrowth performance of tropical forage legumes on infertile soils
Authors: L. Amar Andi , J. Coventry Ross , A. Congdon Robert , P. Gardiner Christopher
Published: July 2023

Survival, herbage yield and nutrient use efficiency of ten tropical forage legumes were compared in pot trials using two soil types (red and yellow kandosols), widespread in Australia’s tropical rangelands, over a period of 22 months. Over this period, plants of Centrosema brasilianum cv. Oolloo, Desmodium virgatus, Macroptilium bracteatum (93.8%), Stylosanthes scabra, S. hamata (87.5%) and D. pubescens (68.8%) survived best. Arachis paraguariensis (37.5%), A. triseminalis, M. martii (25.0%) and C. pascuorum (18.8%) were less successful. The highest herbage yields were consistently produced by C. brasilianum, followed by M. bracteatum and the Stylosanthes cultivars. The annual species, C. pascuorum and M. martii gave high yields in the first 3 9-weekly harvests. The Stylosanthes cultivars produced most root nodules, followed by A. paraguariensis, C pascuorum, C. brasilianum and M. martii. D. pubescens, D. virgatus, M. martii, A. triseminalis and C. brasilianum had the highest nitrogen-use efficiencies, whilst C. brasilianum and the two Stylosanthes cultivars had the highest phosphorus-use efficiencies. All of the legumes increased the nitrogen content of the two soils significantly, especially S. hamata, A. paraguariensis, C. brasilianum, M. martii and M. bracteatum. Most of the legumes show promise for use in low-fertility tropical pastures, particularly C. brasilianum and M. bracteatum.