bluuebunny/crossref_metadata_2025 huggingface dataset:
The impact of metastasectomy on survival of patients with synchronous metastatic renal cell cancer in Finland: A nationwide study
Authors: Laru Lauri , Ronkainen Hanna , Ohtonen Pasi , Vaarala Markku H.
Published: March 2024

Background and objective:

Most of the studies on metastasectomy in renal cell cancer are based on metachronous, often oligometastatic disease. Prior data on the impact of metastasectomy in synchronous metastatic renal cell cancer (mRCC) is, however, very scarce. We aimed to investigate the role of complete and incomplete metastasectomy in a large, nationwide patient population.

Methods:

We analyzed nationwide data, including all synchronous mRCC cases in Finland diagnosed during a 6-year period identified from the Finnish Cancer Registry, and complemented with patient records from the treating hospitals. We only included the patients who underwent removal of the primary tumor by nephrectomy. We performed univariate and multivariable adjusted analysis to identify the effect of metastasectomy on overall survival (OS) and cancer-specific survival (CSS).

Results:

We included 483 patients with synchronous mRCC. Overall, 57 patients underwent complete and 96 incomplete metastasectomy, while 330 patients had no metastasectomy. The median OS was 17.9 and CSS 17.2 months for all patients. The median OS and the median CSS were 59.3 and 60.8 months for the complete, 21.9 and 25.1 for the incomplete, and 14.5 and 14.8 months for the no metastasectomy groups ( p < 0.001 for differences). In both applied multivariable statistical models, the OS and CSS benefit from complete metastasectomy remained significant (hazard ratios (HRs) varied between 0.42 and 0.54, p < 0.001) compared with the no metastasectomy group. However, there was no improvement in survival estimates in the incomplete metastasectomy group compared with the no metastasectomy group (HRs varied between 1.04 and 1.10, p > 0.40).

Conclusions:

Complete metastasectomy, when possible, can be considered as a treatment option for selected patients with synchronous mRCC who are fit for surgery. By contrast, we found no survival benefit from an incomplete metastasectomy suggesting that such procedures should not be performed for these patients.
A Thief in School: A Found Poem Capturing the Impact of Lockdown Drills in Schools
Authors: Cormier Kerry K.
Published: March 2024

This found poem combines a notice of a lockdown drill, my reactions, and my children’s interpretations of the event. Drawing on motherscholarship, the poem expresses my concern as a mother for my children as they experience these drills and my dismay as an educator at how such drills are embedded in our culture. Three perspectives in the poem capture how a regular occurrence impacts students, schools, and communities. This work adds to conversations circulating around the culture of school security, the impact of lockdown drills on both students and families, and serves as a means of mothering activism.
HCC-Check: A Novel Diagnostic Tool for Early Detection of Hepatocellular Carcinoma Based on Cytokeratin-1 and Epithelial Membrane Antigen: A Cross-Sectional Study
Authors: Attallah Kareem A. , Albannan Mohamed S. , Farid Khaled , Rizk Sherine M. , Fathy Nevine
Published: March 2024

Background: Hepatocellular carcinoma is frequently diagnosed in advanced stages, leading to a poorer prognosis. Therefore, early diagnosis and identification of biomarkers may significantly improve outcomes. Methods: This cross-sectional study enrolled 486 participants distributed among 3 groups: F1 to F3 = 184, F4 = 183, and hepatocellular carcinoma = 119. Liver fibrosis staging was performed using FibroScan, while imaging features were used for hepatocellular carcinoma detection. Epithelial membrane antigen and cytokeratin-1 levels in serum were quantified through Western blot and ELISA, respectively. Results: Patients diagnosed with hepatocellular carcinoma exhibited significantly elevated levels of epithelial membrane antigen and cytokeratin-1 compared to non-hepatocellular carcinoma patients, with a highly significant statistical difference ( P < .0001). Epithelial membrane antigen demonstrated diagnostic performance with an area under the curve of 0.75, a sensitivity of 69.0%, and a specificity of 68.5%. Cytokeratin-1 for the identification of hepatocellular carcinoma showed a sensitivity of 79.0% and a specificity of 81.4%, resulting in an area under the curve of 0.87. The developed HCC-Check, which incorporates epithelial membrane antigen, cytokeratin-1, albumin, and alpha-fetoprotein, displayed a higher area under the curve of 0.95 to identify hepatocellular carcinoma, with a sensitivity of 89.8% and a specificity of 83.9%. Notably, HCC-Check values exceeding 2.57 substantially increased the likelihood of hepatocellular carcinoma, with an estimated odds ratio of 50.65, indicating a higher susceptibility to hepatocellular carcinoma development than those with lower values. The HCC-Check diagnostic test exhibited high precision in identifying patients with hepatocellular carcinoma, particularly those with small tumor sizes (<5 cm) and a single nodule, as reflected in area under the curve values of 0.92 and 0.85, respectively. HCC-Check was then applied to the validation study to test its accuracy and reproducibility, showing superior area under the curves for identifying different stages of hepatocellular carcinoma. These outcomes underscore the effectiveness of the test in the early detection of hepatocellular carcinoma. Conclusion: The HCC-Check test presents a highly accurate diagnostic method for detecting hepatocellular carcinoma in its early stages.
White Light Stimulation at Gamma Frequency to Modify the Aβ42 and tau Proteins in SH-SY5Y Cells
Authors: Chang Yang-Pei , Chien Ching-Fang , Huang Ling-Chun , Chuu Chih-Pin , Chang Hsi-Wen , Hour Tzyh-Chyuan , Yang Yuan-Han
Published: March 2024

Background

Non-invasive 40 Hz gamma frequency stimulation has shown improved cognition and memory recall in Alzheimer’s disease (AD).

Purpose

The present study investigates the effects of white light stimulation at gamma frequency on SH-SY5Y cells using Delta M + BrainCare Light without causing discomfort.

Methods

SH-SY5Y cells were exposed to The Delta M + BrainCare Light for 15, 30, 45, and 60 minutes. The secretion of amyloid-β42 (Aβ42), p-AKT (Ser473), AKT, p-mTOR (Ser2448), mTOR, p-4E-BP1 (Thr37/46), 4E-BP1, p-tau (Thr181), and tau were analyzed. Aβ42 fibril aggregation and phagocytosis of FITC-Aβ42 in BV-2 cells were also observed.

Results

Delta M + BrainCare Light reduced tau, AKT, and p-mTOR and increased p-4E-BP1 in SH-SY5Y cells. Further, it inhibited secretion and aggregation of Aβ42, alongside increased phagocytosis in microglial cells.

Conclusion

These findings underscore the potential of the Delta M + BrainCare Light in mitigating the associated proteins and pathways implicated in AD.
Bojungikgi-tang for Chemotherapy-induced Leukopenia: A Systematic Review and Meta-Analysis
Authors: Ahn Lib , Park Song Won , Choi Dong-jun
Published: March 2024

Chemotherapy-induced leukopenia is a common side effect of cytotoxic anticancer drugs. It can deprive patients of treatment opportunities, resulting in the delay, reduction, or discontinuation of chemotherapy or other anticancer drug administration. Two researchers searched English, Chinese, Japanese, and Korean electronic databases, without limiting the time period and language, using search terms such as “Bojungikgi,” “WBC,” “leuko,” and “neutrop.” Among the human randomized controlled studies in which Bojungikgi-tang was administered to patients who underwent chemotherapy, studies reporting leukopenia-related outcomes were selected, and data extraction, bias risk assessment, and meta-analysis were performed on the selected papers. Ten studies were selected, and a systematic review with meta-analysis was conducted. Nine papers were published in China and the total number of participants was 715. As a result of administering Bojungikgi-tang to these patients, the number of patients with chemotherapy-induced leukopenia significantly decreased (OR: 0.41, 95% CI: 0.27-0.61, P = .0001, I2 = 35%). Further, white blood cell counts were compared with that of the control group, and it showed an effect on prevention (MD: 0.64, 95% CI: 0.46-0.83, P < .00001, I2 = 90%). A pronounced effect was observed, especially when administered after a diagnosis based on the pattern identification, such as Qi deficiency. (OR: 0.32, 95% CI: 0.18-0.58, P = .0002, I2 = 0%). However, all studies had a high risk of bias due to non-blinding, and most studies had a high or uncertain risk of bias in creating random assignment orders and concealing them. Bojungikgi-tang has an effect on the prevention and treatment of chemotherapy-induced leukopenia. The effect rate can be increased when administered after proper diagnosis, and the possibility of adverse reactions and side effects is lower than that of Granulocyte-Colony Stimulating Factor (G-CSF) injection. Bojungikgi-tang appears to be useful in the treatment and prevention of leukopenia caused by cytotoxic anticancer drugs. However, it is necessary to conduct high-quality clinical studies in the future, considering the possibility of local and language bias, heterogeneity of carcinoma and intervention, and the risk of bias.

Registration: PROSPERO CRD4202341054.
Arbovirus surveillance in mosquitoes: Historical methods, emerging technologies, and challenges ahead
Authors: Maia Luis Janssen , Oliveira Cirilo Henrique de , Silva Arthur Batista , Souza Pedro Augusto Almeida , Müller Nicolas Felipe Drumm , Cardoso Jader da Cruz , Ribeiro Bergmann Morais , Abreu Filipe Vieira Santos de , Campos Fabrício Souza
Published: March 2024

Arboviruses cause millions of infections each year; however, only limited options are available for treatment and pharmacological prevention. Mosquitoes are among the most important vectors for the transmission of several pathogens to humans. Despite advances, the sampling, viral detection, and control methods for these insects remain ineffective. Challenges arise with the increase in mosquito populations due to climate change, insecticide resistance, and human interference affecting natural habitats, which contribute to the increasing difficulty in controlling the spread of arboviruses. Therefore, prioritizing arbovirus surveillance is essential for effective epidemic preparedness. In this review, we offer a concise historical account of the discovery and monitoring of arboviruses in mosquitoes, from mosquito capture to viral detection. We then analyzed the advantages and limitations of these traditional methods. Furthermore, we investigated the potential of emerging technologies to address these limitations, including the implementation of next-generation sequencing, paper-based devices, spectroscopic detectors, and synthetic biosensors. We also provide perspectives on recurring issues and areas of interest such as insect-specific viruses.
Newly Identified KCNA3 Gene Variants Put the “Excite”-ment Back in Kv1.3 Channelopathy
Authors: Glasscock Edward
Published: March 2024

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Sleeping High and Getting Lost on the Spiky Road: What Affects Visual Memory in Older Adults With Epilepsy, and What Can We Do About It?
Authors: Marawar Rohit
Published: March 2024

[Box: see text]
Formal Constraints and Creativity: Connecting Game Jams, Dogma ’95, the Demo Scene, OuBaPo, and Renga poets
Authors: Lai Gorm , Vecchi Ilaria
Published: March 2024

In a fast-paced world of ever-changing trends, connecting historical roots by linking new movements to existing traditions can be a challenge. Similarly to how Mary Flanagan’s book “Critical Play” situates and contextualizes play in history, we propose and start similar work on game jams. While we don’t have as much room for self-expression in a paper, we focus on two main contributions. The first is to link existing definitions of game jamming and creativity. Secondly, we show how game jams build upon existing traditions of co-creation—sharing and confronting ideas with peers by using formal constraints to fuel creativity and direct the process. To this end, we examine four historic movements—the Danish film movement Dogma ’95, creators of audio visual programs from the demo scene, OuBaPo a group of French comic book writers, and the Japanese renga poets—and relate them to game jams.
Does Ischemic Core Volume Modify the Treatment Effect of Endovascular Thrombectomy?
Authors: Ballout Ahmad A
Published: March 2024

Imaging-based selection has become integral in guiding endovascular thrombectomy for large vessel occlusive stroke, driven by positive trial outcomes incorporating parenchymal and perfusion imaging criteria. While small-moderate core trials transformed acute reperfusion therapy, uncertainties persisted for large ischemic strokes. This was recently addressed in several treatment trials which demonstrated a benefit of endovascular thrombectomy in patients with large ischemic strokes, defined by parenchymal and/or perfusion imaging. Although individual trials suggest treatment benefits regardless of core size, patient-level meta-analyses are essential to clarify this relationship. Our aim was to summarize the imaging ramifications of the major endovascular thrombectomy trials of the past decade focusing on the interaction between the core and the treatment effect, to assist in the design of future meta-analyses. The core-treatment relationship that will be investigated in these meta-anlalyses will likely have major implications in our systems of care designs and in determining the utility of imaging-based selection.
3D digital subtracted angiography venous roadmapping for endovascular management of dural venous stenosis
Authors: Zhu François , Liao Liang , Bracard Serge , Harsan Oana , Lopes De Medeiros Luana , Derelle Anne-Laure , Braun Marc , Gory Benjamin , Anxionnat René
Published: March 2024

Stenting of the dural venous sinuses has emerged as a therapeutic option for intracranial hypertension and pulsatile tinnitus. However, venous endovascular navigation faces challenges due to lower-quality roadmaps compared to arterial navigation. This study explores the application of three-dimensional (3D) rotational venography in assessing the cerebral venous vasculature and its potential for venous navigation. The methods involve venous 3D digital subtracted angiography (DSA) in patients with dural venous stenosis, with image acquisition using a biplane angiographic system. The results highlight the enhanced spatial resolution of 3D venous imaging, providing anatomical information crucial for precise characterization of stenosis and understanding cortical venous drainage. 3D venous roadmapping is shown to improve endovascular venous navigation, offering synchronized and rotatable 3D roadmaps, providing a comprehensive approach to optimize endovascular venous interventions.
Therapeutic potential of elafin in airway inflammatory disease
Authors: He Mingxin , Yang Yalou , Li Yanyan , Zhou Xiangdong , Xu Li , Zhang Ziwei , Zhang Hua , Li Qi
Published: March 2024

Elafin, which is derived from trappin-2 or pre-elafin by proteolysis, is an endogenous serine protease inhibitor with a low molecular weight. Its inhibitory activity is dependent on anchoring to the extracellular matrix by forming covalent bonds with its distinctive N-terminal domain via tissue transglutaminases. In addition to inhibiting proteases, it also exhibits anti-inflammatory, antibiotic, antifungal, antiviral and immunomodulatory functions. Elafin plays an important role in inflammatory disease and is a promising candidate for the anti-inflammatory treatment of respiratory diseases. This review will discuss the therapeutic potential of elafin in airway inflammation and provide evidence and suggestions for the future treatment of airway inflammatory diseases. In addition, the therapeutic potential of elafin in lung cancer is also discussed.
A safety estimand for late phase clinical trials where the analysis period varies over the subjects
Authors: Hedman Katarina , Lisovskaja Vera , Nyström Per
Published: March 2024

Background/Aims

Evaluating safety is as important as evaluating efficacy in a clinical trial, yet the tradition for safety analysis is rudimentary. This article explores more complex methodologies for safety evaluation, with the aim of improving the interpretability, as well as generalizability, of the results.

Methods

For studies where the analysis periods vary over the subjects, using the International Council for Harmonisation estimand framework, we construct a formal estimand that could be used in the setting of safety surveillance that answers the clinical question of ‘What is the magnitude of the increase in risk of experiencing an adverse event if the treatment is taken, as prescribed, for a specific period of time?’. Estimation methodologies for this estimand are also discussed.

Results

The proposed estimand is similar to that found in the efficacy analyses of time to event data (e.g. in outcome studies), with the key difference of utilization of hypothetical intercurrent event strategy for the intercurrent event of treatment discontinuation. This is motivated by what we perceive to be a key difference for the safety objective compared to efficacy objectives, namely a desire for sensitivity (i.e. greater possibility of detecting a negative impact of the drug, if such exists) as opposed to the need to prove a positive effect of the drug in a conservative manner.

Conclusion

It is valuable, and possible, to use the International Council for Harmonisation estimand framework not only for efficacy but also for safety evaluation, with the estimand driven by an interpretable, and relevant, clinical question.
Confidentiality and privacy considerations for adolescents receiving contraceptive health services via telemedicine: A narrative review
Authors: Reilly Kristen , Ebersole Ashley
Published: March 2024

Confidential medical care for adolescent patients is essential as they are likely to forgo needed care if privacy cannot be maintained. The use of telemedicine for adolescent health has rapidly expanded due to the COVID-19 pandemic and can increase access to important services like reproductive care; however, it has raised challenges for providers, patients, and their parents/guardians related to confidentiality and privacy. Health care providers are often uncertain about the laws and regulations that govern confidential services including the 21st Century Cures Act. Through a narrative review of studies on confidentiality and telemedicine, this article seeks to summarize the available evidence and provide recommendations on maintaining privacy during virtual encounters and identify current best practices for prescribing contraception via telemedicine.
Effects of attentional focus strategy on drop jump for athletes with different experience levels: Performance, kinetics and kinematics
Authors: Furuhashi Yuki , Yoshida Takuya , Ota Kazuki , Muratomi Kotaro , Hayashi Ryohei , Tanigawa Satoru , Maemura Hirohiko
Published: March 2024

The attentional focus strategy (AFS) affects drop jump (DJ) performance; however, its effects on DJ kinetics and kinematics are unclear. This study examines the effects of AFS on DJ performance, kinetics and kinematics. Forty collegiate males were divided into a DJ experienced group and a DJ inexperienced group, and they performed two trials of DJs after listening to instructions designed to elicit internal (INT), external (EXT) or neutral (NEUT) focus of attention. In the experienced group, the reactive strength index (RSI) was larger with the NEUT than with the INT. Hip joint torque and positive hip joint power in the concentric phase was smaller with the NEUT than with the INT, and the hip joint angle at the lowest centre of mass was larger with the NEUT than with the INT ( p < .05). In the inexperienced group, RSI was larger with the EXT than with the INT. Further, the hip joint torque in the concentric phase was smaller with the EXT than with the INT; positive ankle joint power was larger with the EXT than with the INT; and the hip joint angles at the lowest centre of mass and take-off were larger with the EXT than with the INT ( p < .05). These results showed that the AFS affected the DJ performance, kinetics and kinematics and suggested that effective DJ training may be achieved with the NEUT for DJ experienced and with the EXT for DJ inexperienced.
Prevalence and patterns of laxative use in subjects with self-reported constipation: results from a multinational digestive health survey
Authors: Lacy Brian E. , Delfini Régis , Fladung Bernward , Lange Robert
Published: March 2024

Background:

Constipation is characterized by symptoms of straining, hard stool, difficult evacuation, and infrequent bowel movements. Online surveys provide valuable information about patients’ perspectives, symptoms, management, treatment satisfaction, and risk factors.

Methods:

This survey explored subject experiences involving 20 gastrointestinal (GI) conditions. In total, 20,099 respondents in seven countries with varied cultural and socioeconomic backgrounds participated. Post hoc analysis of ‘self-reported constipation’ and related symptoms experienced within the past 6 months and the last episode of constipation provided data on prevalence, demographics, frequency and duration of episodes and related symptoms, impact on quality of life (QoL), management with or without laxatives, and resulting treatment satisfaction.

Results:

In total, 10,425 subjects reported constipation within 6 months and 2637 at the last episode. Prevalence was highest in females and younger adults. Most subjects reported various coexisting GI symptoms. Almost 80% of 6865 episodes reported by 5337 subjects occurred every 2–3 months to every 2–3 weeks. A higher frequency of constipation correlated with a greater impact on QoL. On a 10-point scale, the mean impact was 6.4. More than 90% of respondents had episodes ranging from 1 day to 1 week. More than 90% took action; 16% used laxatives, of whom 80.3% were satisfied.

Conclusion:

Constipation, a highly prevalent disorder, spans cultures and socioeconomic classes. Its chronic recurrence has a significant impact on QoL, resulting in symptom self-management in >90% of subjects. Significantly higher satisfaction rates in subjects treated with than without laxatives reflect subjects’ reports that self-reported constipation can be treated effectively with laxatives.
Effectiveness and safety of azathioprine for inflammatory pouch disorders: results from the RESERVO study of GETECCU
Authors: Mesonero Francisco , Zabana Yamile , Fernández-Clotet Agnès , Leo-Carnerero Eduardo , Caballol Berta , Núñez-Ortiz Andrea , García María José , Bertoletti Federico , Mínguez Alejandro , Suris Gerard , Casis Begoña , Ferreiro-Iglesias Rocío , Calafat Margalida , Jiménez Itxaso , Miranda-Bautista José , Lamuela Luis Javier , Fajardo Ingrid , Torrealba Leyanira , Nájera Rodrigo , Sáiz-Chumillas Rosa María , González Irene , Vicuña Miren , García-Morales Natalia , Gutiérrez Ana , López-García Alicia , Benítez José Manuel , Rubín de Célix Cristina , Tejido Coral , Brunet Eduard , Hernández-Camba Alejandro , Suárez Cristina , Rodríguez-Lago Iago , Piqueras Marta , Castaño Andrés , Ramos Laura , Sobrino Ana , Rodríguez-Grau María Carmen , Elosua Alfonso , Montoro Miguel , Baltar Ruth , Huguet José María , Hermida Benito , Caballero-Mateos Antonio , Sánchez-Guillén Luis , Bouhmidi Abdel , Pajares Ramón , Baston-Rey Iria , López-Sanromán Antonio , Albillos Agustin , Barreiro-de Acosta Manuel
Published: March 2024

Background:

The usefulness of thiopurines has been poorly explored in pouchitis and other pouch disorders.

Objective:

To evaluate the effectiveness and safety of azathioprine as maintenance therapy in inflammatory pouch disorders.

Design:

This was a retrospective and multicentre study.

Methods:

We included patients diagnosed with inflammatory pouch disorders treated with azathioprine in monotherapy. Effectiveness was evaluated at 1 year and in the long term based on normalization of stool frequency, absence of pain, faecal urgency or fistula discharge (clinical remission), or any improvement in these symptoms (clinical response). Endoscopic response was evaluated using the Pouchitis Disease Activity Index (PDAI).

Results:

In all, 63 patients were included [54% males; median age, 49 (28–77) years]. The therapy was used to treat pouchitis ( n = 37) or Crohn’s disease of the pouch ( n = 26). The rate of clinical response, remission and non-response at 12 months were 52%, 30% and 18%, respectively. After a median follow-up of 23 months (interquartile range 11–55), 19 patients (30%) were in clinical remission, and 45 (66%) stopped therapy. Endoscopic changes were evaluated in 19 cases. PDAI score decreased from 3 (range 2–4) to 1 (range 0–3). In all, 21 patients (33%) presented adverse events and 16 (25%) needed to stop therapy.

Conclusion:

Azathioprine may be effective in the long term for the treatment of inflammatory pouch disorders and could be included as a therapeutic option.
China's Smart Diaspora Governance: Extraterritorial Social Control Through Digital Platforms
Authors: Thunø Mette , Wang Yiwen
Published: March 2024

This article investigates the transformative impact of information communication technology on China's extraterritorial governance practices directed at Chinese populations residing overseas. Employing textual analysis on official documents, media reports, and data from qualitative interviews with ethnic Chinese association leaders in Europe, we contend that e-governance and social media platforms, notably Weixin, are instrumental in reshaping transnational space by facilitating enhanced overseas social control. Digital technology enables local Chinese officials to extend domestic security and judicial practices by empowering overseas Chinese association leaders as on-the-ground liaison and information conduits. The implementation of e-government services further amplifies the local party-state's access to, and the collection of data pertaining to Chinese emigrants. Drawing on a case study of Qingtian County in Zhejiang province, we posit that China's diaspora governance needs to be understood in the broader context of China's swiftly evolving digital landscape, where Weixin assumes a pivotal role as a digital infrastructure.
A Detailed Analysis of Workplace Foot and Ankle Injuries
Authors: Galasso Annemarie , Caughman Alexander M. , Griffith Adam , Hoch Caroline , Rex James , Scott Daniel J. , Gross Christopher E.
Published: March 2024

Introduction

This study analyzes the incidence rate and median workdays missed due to foot and ankle injuries across age groups, sexes, and industries.

Methods

Workplace injury data from 2003 to 2019 were obtained using the Nonfatal Cases Involving Day Away from Work: Selected Characteristics database provided by the Bureau of Labor Statistics (BLS). The data were grouped by injury location (ie, foot, ankle), injury type (ie, fracture, sprain), and industry, and reported with injury incidence rates and median workdays missed.

Results

The incidence rate of foot and ankle injuries significantly decreased from 2003 to 2019 (P < .001). With increasing age, the incidence rate of foot and ankle injuries decreased (P < .001) and median workdays missed increased (P < .001). Men had significantly higher rates of foot and ankle injuries (P < .001). Agriculture, forestry, fishing, and hunting (foot=10.23%, ankle=10.41%); construction (foot=8.14%, ankle=8.68%); and transportation and warehousing (foot=11.06%, ankle=13.80%) industries had the highest injury incidence rates. Transportation and warehousing (foot=16.8 days, ankle=16.3 days), mining (foot=44.9 days, ankle=17.1 days), and utilities (foot=26.7 days, ankle=24.4 days) industries had the highest median workdays missed.

Conclusion

Increased incidence and severity of workplace foot and ankle injuries are associated with male sex and heavy labor industries. Age was positively associated with severity and negatively associated with incidence of workplace ankle injuries.

Levels of Evidence:

Level III, Retrospective cohort study
Starch/rhodamine 6G conjugate as a non-cytotoxic, effective, and selective fluorescent chemosensor for detection of Fe3+ ion
Authors: Alavifar Seyyed-Mahdi , Golshan Marzieh , Salami Hosseini Mahdi , Salami-Kalajahi Mehdi
Published: March 2024

Iron is a crucial trace mineral vital for maintaining optimal human health and well-being. Despite being needed in small amounts, its importance cannot be overstated as it plays an important role in various physiological processes. In this research, we have developed a fluorescence probe utilizing starch functionalized with derivatives of rhodamine 6G to efficiently detect Fe3+ ions. This structure forms self-assembled starch/rhodamine 6G (RS0) fluorescent nanoparticles that exhibit strong fluorescence intensity under ultraviolet light. The ability of Fe3+ ions to increase the fluorescence of the RS0 probe enables the effective detection of Fe3+ ions. Importantly, this fluorescence increasing effect is specific to Fe3+ ions and remains unaffected by the presence of other metal ions. MTT assay against SH-SY5Y cells showed that RS0 was rather cytocompatible. Finally, SH-SY5Y cells were used to measure cell uptake and fluorescence imaging performances of RS0 which showed a good ability for live-cell fluorescence imaging.
Epidemiology of gout – Global burden of disease research from 1990 to 2019 and future trend predictions
Authors: Han Tingfen , Chen Wenli , Qiu Xiasang , Wang Weijie
Published: March 2024

Background:

Understanding the global burden of gout in the past and future can provide important references for optimizing prevention and control strategies in healthcare systems.

Objectives:

This study aimed to report variations in the global disease burden and risk factors of gout in 204 countries and territories from 1990 to 2019.

Design:

We conducted a retrospective analysis of gout based on the latest Global Burden of Disease (GBD) 2019 database.

Methods:

We collected data on the prevalence, incidence, and disability-adjusted life years (DALYs) of gout from 1990 to 2019. The data were then stratified by age, sex, and economic development level. Decomposition analysis, frontier analysis, and prediction models were used to analyze the changes and influencing factors influencing each indicator.

Results:

Globally, there were 53,871,846.4 [95% uncertainty interval (UI): 43,383,204.6–66,342,327.3] prevalent cases, 92,228,86.8 (95% UI: 7419,132.1–11,521,165) incident cases, and 1673,973.4 (95% UI: 1,068,061.1–2,393,469.2) cases of DALYs of gout in 2019, more than double those in 1990. Moreover, the pace of increase in the age-standardized prevalence rate (ASPR), age-standardized incidence rate (ASIR), and age-standardized DALY rate (ASDR) accelerated during 1990–2019, with estimated annual percentage changes (EAPC) of 0.94 [95% confidence interval (CI): 0.85–1.03], 0.77 (95% CI: 0.69–0.84), and 0.93 (95% CI: 0.84–1.02), respectively, especially among men. The disease burden of gout has increased in all the other 20 GBD regions in the past 30 years, except Western Sub-Saharan Africa. The highest risk of high body mass index (BMI) and kidney dysfunction was in high-income countries such as North America and East Asia. The global prevalence rate, incidence rate, and DALYs rate of gout in 2030 will reach 599.86, 102.96 per 100,000 population, and 20.26 per 100,000 population, respectively, roughly the same as in 2019.

Conclusion:

With the development of society, the disease burden of gout will become increasingly severe. It is very important to study the accurate epidemiological data on gout for clinical diagnosis and treatment and health policy.
Patient-reported outcomes on sleep quality and circadian rhythm during treatment with intravenous ketamine for treatment-resistant depression
Authors: Yan Raymond , Marshall Tyler , Khullar Atul , Nagle Travis , Knowles Jake , Malkin Mai , Chubbs Brittany , Swainson Jennifer
Published: March 2024

Background:

Intravenous (IV) ketamine is a rapid acting antidepressant used primarily for treatment-resistant depression (TRD). It has been suggested that IV ketamine’s rapid antidepressant effects may be partially mediated via improved sleep and changes to the circadian rhythm.

Objectives:

This study explores IV ketamine’s association with changes in patient-reported sleep quality and circadian rhythm in an adult population with TRD.

Methods:

Adult patients (18–64 years) with TRD scheduled for IV ketamine treatment were recruited to complete patient rated outcomes measures on sleep quality using the Pittsburgh Sleep Quality Index (PSQI) and circadian rhythm using the Morningness–Eveningness Questionnaire (MEQ). Over a 4-week course of eight ketamine infusions, reports were obtained at baseline (T0), prior to second treatment (T1), prior to fifth treatment (T2), and 1 week after eighth treatment (T3).

Results:

Forty participants with TRD (mean age = 42.8, 45% male) were enrolled. Twenty-nine (72.5%) had complete follow-up data. Paired t tests revealed statistically significant improvements at the end of treatment in sleep quality (PSQI) ( p = 0.003) and depressive symptoms (Clinically Useful Depression Outcome Scale-Depression, p < 0.001) while circadian rhythm (MEQ) shifted earlier ( p = 0.007). The PSQI subscale components of sleep duration ( p = 0.008) and daytime dysfunction ( p = 0.001) also improved. In an exploratory post hoc analysis, ketamine’s impact on sleep quality was more prominent in patients with mixed features, while its chronobiotic effect was prominent in those without mixed features.

Conclusion:

IV ketamine may improve sleep quality and advance circadian rhythm in individuals with TRD. Effects may differ in individuals with mixed features of depression as compared to those without. Since this was a small uncontrolled study, future research is warranted.
Diffuse Kaposi sarcoma with oral involvement in a person diagnosed with human immunodeficiency virus/acquired immune deficiency syndrome: A case report
Authors: Berrezouga Latifa , Alouani Nada , Kooli Ikbel , Bellalah Ahlem , Chakroun Mohamed
Published: March 2024

Kaposi’s sarcoma is a well-known multifocal vascular tumor initially described by pathologist Moritz Kaposi. This report presents the case of a 38-year-old bisexual male who consulted the infectious diseases department with non-itchy maculopapular and purpuric lesions on the skin with the involvement of the oral mucosa, suggesting a diagnosis of Kaposi’s sarcoma. Biological and radiological investigations were performed. The patient was found to be human immunodeficiency virus positive with a viral load of 251.000/mL and a CD4 count of 182/mm3. In addition, secondary syphilis was diagnosed. Histopathological examinations confirmed HHV-8 KS. The patient was treated with Extencilline® and antiretroviral therapy. After 10 months of chemotherapy, a favorable outcome was noted with complete resolution of skin and oral mucosa lesions.
Pleomorphic adenoma of the parotid gland concomitant with tuberculosis infection: A case report and review of the literature
Authors: Chiboub Dorra , Romdhane Nadia , Jameleddine Esma , Rejeb Emna , Khanchel Fatma , Jouini Raja , Zoghlami Imen , Nefzaoui Safa , Hariga Ines , Mbarek Chiraz
Published: March 2024

Tuberculosis of the salivary glands and particularly of the parotid gland is a localization that remains rare even in endemic countries. The association of intra parotid tuberculosis with a benign tumor has been found only in rare cases in literature. A 50-year-old woman with a history of normal pressure hydrocephalus treated surgically, non-smoker, presented with a right parotid swelling progressively increasing in size for 3 years. Clinical examination revealed a 4 cm long, firm, mobile, painless parotid swelling without inflammatory signs and without accessory lymphadenopathy. The oropharyngeal examination was without abnormalities. Ultrasound showed a mass of 31 × 27 mm suggesting a pleomorphic adenoma. MRI confirmed the suspicion of a pleomorphic adenoma of both lobes. The patient underwent a conservative total parotidectomy. The extemporaneous examination was in favor of a pleomorphic adenoma while the final pathology showed the coexistence of active tuberculosis lesions. The patient was put on long-term antituberculosis treatment with good clinical evolution. The clinical presentation of parotid tuberculosis is nonspecific mimicking any other tumor and the diagnosis can only be made by histological examination. Therapeutic management is based on long-term antituberculosis treatment.
Barriers and facilitators to acceptance and implementation of eMental-health intervention among older adults: A qualitative systematic review
Authors: Peng Ruotong , Li Xiaoyang , Guo Yongzhen , Ning Hongting , Huang Jundan , Jiang Dian , Feng Hui , Liu Qingcai
Published: March 2024

Objective

Electronic mental health interventions are effective but not well promoted currently among older adults. This study sought to systematically review and summarize the barriers and facilitators of accepting and implementing electronic mental health interventions among older adults.

Methods

We comprehensively retrieved six electronic databases from January 2012 to September 2022: PubMed, Web of Science, Embase, Scopus, PsycINFO, and CINAHL. The JBI-QARI was used to assess the quality of the research methodology of each publication. Eligible studies underwent data coding and synthesis aligned to inductive and deductive methods. The Consolidated Framework for Implementation Research 2.0 was used as a deductive framework to guide a more structured analysis.

Results

The systematic review screened 4309 articles, 17 of which were included (eight with mixed methods and nine with qualitative methods). We identified and extracted the barriers and facilitators of accepting and implementing electronic mental health interventions among older adults: (1) innovation: technology challenges, optimized functions, and contents, security and privacy; (2) outer setting: community engagement and partnerships, financing; (3) inner setting: leadership engagement, available resources, incompatibility, intergenerational support, training and guidance; (4) individuals: perceptions, capability, motivation of older adults and healthcare providers; and (5) implementation process: recruit, external assistance, and team.

Conclusion

These findings are critical to optimizing, promoting, and expanding electronic mental health interventions among older adults. The systematic review also provides a reference for better evidence-based implementation strategies in the future.
Does Green Finance Policy Contribute to ESG Disclosure of Listed Companies? A Quasi-Natural Experiment from China
Authors: Zhang Changjiang , Zhang Sihan , Zhang Yue , Yang Yuqi , Lan Kai
Published: March 2024

In 2016, the People’s Bank of China (PBC) together with multiple departments issued the Guidance on Building a Green Financial System (the Guidance), which marked a great breakthrough in China’s green finance policy. Aiming to clarify the actual impact and underlying mechanisms of green finance policy on Chinese listed companies’ ESG disclosure quality, this study employs the difference-in-differences (DID) model and examines the impact of the Guidance on ESG disclosure practices of A-share listed companies on the Shanghai Stock Exchange (SSE) and the Shenzhen Stock Exchange (SZSE) during the period 2006 to 2022. This study reveals a positive correlation between the Guidance and listed companies’ ESG disclosure. Upon further examination, it becomes evident that the Guidance has a more noticeable positive impact on the quality of ESG disclosure among listed companies that operate in industries with high levels of pollution, state-owned enterprises, and regions that exhibit greater levels of economic development. This paper provides essential insights to policymakers, facilitating a deeper understanding and more thorough assessment of the economic implications of green finance policies. Additionally, it acts as a strategic resource for listed companies, guiding the enhancement of corporate ESG disclosures and the implementation of ESG strategies influenced by green finance policies.
Outcomes of Concomitant Glenohumeral Stabilization After Arthroscopic Rotator Cuff Repair in Military Patients Younger Than 40 Years
Authors: Green Clare K. , Scanaliato John P. , Sandler Alexis B. , Patrick Cole M. , Dunn John C. , Parnes Nata
Published: March 2024

Background:

While concomitant rotator cuff and inferior labral tears are relatively uncommon in young civilians, military populations represent a unique opportunity to study this injury pattern.

Purpose:

To (1) evaluate the long-term outcomes after combined arthroscopic rotator cuff and inferior labral repair in military patients <40 years and (2) compare functional outcomes with those after isolated arthroscopic rotator cuff repair.

Study Design:

Cohort study; Level of evidence, 3.

Methods:

Military patients who underwent arthroscopic rotator cuff repair between January 2011 and December 2016 and had a minimum of 5-year follow-up data were included in this study. The patients were categorized into those who had undergone combined arthroscopic rotator cuff and inferior labral repair (RCIL cohort) and those who had isolated arthroscopic rotator cuff repair (ARCR cohort). Pre- and postoperative outcome measures—visual analog scale for pain, Single Assessment Numeric Evaluation, American Shoulder and Elbow Surgeons shoulder score, Rowe Instability Score, and range of motion—were compared between the groups.

Results:

A total of 50 shoulders (27 in the RCIL cohort and 23 in the ARCR cohort) were assessed. The RCIL and ARCR groups were similar in terms of age (mean, 33.19 years [range, 21-39 years] vs 35.39 years [range, 26-39 years], respectively) and sex (% male, 88.46% vs 82.61%, respectively). All patients were active-duty military at the time of surgery. The mean final follow-up was at 106.93 ± 16.66 months for the RCIL group and 105.70 ± 7.52 months for the ARCR group ( P = .75). There were no differences in preoperative outcome scores between groups. Postoperatively, both groups experienced statistically significant improvements in all outcome scores ( P < .0001 for all), and there were no significant group differences in any final postoperative outcome measures. At the final follow-up, 26 (96.30%) patients in the RCIL cohort and 20 (86.96%) in the ARCR cohort had returned to unrestricted active-duty military service ( P = .3223).

Conclusion:

The findings of this study suggest that concomitant glenohumeral stabilization does not portend worse outcomes after arthroscopic rotator cuff repair in military patients < 40 years. Combined repair produced statistically and clinically significant improvements in outcome scores at the long-term follow-up, indicating that simultaneous repair of combined lesions was an appropriate treatment option in this patient population.
The Top 100 Most Impactful Articles on the Achilles Tendon According to Altmetric Attention Score and Number of Citations
Authors: Bano Joseph M. , Rate William R. , Civilette Matthew D. , Wyand Trevor J. , Samuelson Eric R. , Bodendorfer Blake M. , Gould Heath P. , Hembree Walter C.
Published: March 2024

Background:

Achilles tendon injuries often generate substantial discussion in the mainstream media. The Altmetric Attention Score (AAS) measures the online dialogue pertaining to Achilles tendon research that occurs outside scientific journals, which traditional citation-based metrics fail to capture.

Purpose:

To characterize the top 100 most-cited Achilles tendon articles and compare them with the 100 Achilles tendon articles with the highest AAS. A secondary goal was to gain an improved understanding of the online dissemination and interpretation of Achilles tendon research through this comparison.

Study Design:

Cross-sectional study.

Methods:

The Web of Science Clarivate database was queried to isolate the 100 most-cited Achilles tendon articles, and the Altmetric database was queried to identify the Achilles tendon articles with the top 100 AAS values. Data elements were extracted for each article including study type, study topic, and geographic origin.

Results:

The Web of Science Clarivate database search yielded 10,890 articles published between 1970 and 2021. The 100 most-cited articles were published in 35 journals, with the American Journal of Sports Medicine being the most prevalent. The mean (±SD) number of citations was 214.5 ± 86.47. The most prevalent study type was laboratory (28.0%). The most prevalent study topic was treatment (41.0%). Of these articles, 72.0% were European. The Altmetric database search yielded 3810 articles published between 1957 and 2021. The AAS of the top 100 articles ranged from 37 to 476 with a mean of 98.17 ± 85.53. The selected articles were published in 39 journals, with the British Journal of Sports Medicine being the most prevalent. The most prevalent study type was randomized controlled trial (25.0%). The most common study topic was treatment (40.0%). Of these articles, 46.0% were European.

Conclusion:

Our findings suggest that, although the scientific community remains committed to high-impact journals with articles backed by high citation numbers, there is an increasing opportunity to consume Achilles tendon literature through social media.
Factors in the Neonatal Period Associated With Pulmonary Hypertension at 28 Days of Life in Broncho-Pulmonary Dysplasia
Authors: Anh Nguyen Thi Hai , Minh Dien Tran , Thi Ha Le , Thao Nguyen Pham , Thi Hai Van Dang
Published: March 2024

Objectives. To identify factors associated with pulmonary hypertension (PH) at 28 days of life in preterm infants with bronchopulmonary dysplasia (BPD). Methods. This observational study included 128 premature infants with BPD between January 2022 and February 2023 from the neonatal intensive care unit of Vietnam National Children’s Hospital. Results. PH was observed using echocardiography in 29 patients (22.66%). The prevalence of severe BPD in the PH group (62.07%) was significantly higher than that in the non-PH group (18.18%). The multivariate logistic regression showed 2 predictors of PH in BPD: invasive mechanical ventilation up to 28 days of life (odds ratio [OR]:9.440; 95% confidence interval [CI]: 3.090-28.833; P < .001) and history of shock (OR: 2.962; 95% CI: 1.067-8.225; P = .037). Conclusion. We found 2 predictors of PH at 28 days of life in BPD: invasive mechanical ventilation up to 28 days of life and history of shock.
Dyke Davidoff Masson: A Case Report
Authors: Khaoula Boumeriem , Iliass Bourekba , Nazik Allali , Latifa Chat , Siham El Haddad
Published: March 2024

Dyke Davidoff-Masson syndrome is a rare neurological condition that results from brain injury during early childhood stages. The precise incidence of this condition is unknown, with a slight male predominance, and adult forms have been documented. Imaging findings reveal hemisphere atrophy along with ipsilateral compensatory skull changes and hyper-pneumatization of mastoid cells. The treatment approach involves anti-epileptic medications and hemispherectomy is reserved for cases with intractable seizures. This case report delineates the clinical manifestation and therapeutic approach employed in an 8-year-old male patient exhibiting pharmaco-resistant left hemi-body convulsive seizures. The magnetic resonance imaging (MRI) findings revealed right cerebral hemiatrophy, mesencephalon atrophy, ipsilateral calvarial hypertrophy and hyperpneumatization of mastoid cells. The objective of this study is to contribute to the existing literature by presenting this rare case report. We propose that in cases involving pediatric pharmaco-resistant epilepsy, it is essential to conduct further investigations to establish a comprehensive management strategy.