bluuebunny/crossref_metadata_2025 huggingface dataset:
Fotografie w Archiwum Diecezji Łuckiej
Authors: Hamryszczak Artur Paweł
Published: December 2021

Archiwum Diecezji Łuckiej, które jest przechowywane w Ośrodku Archiwów, Bibliotek i Muzeów Kościelnych, ma charakter szczątkowy i gromadzi do­kumentację wytworzoną od II wojny światowej do lat 60. XX wieku, czyli śmierci ordynariusza bpa Adolfa Szelążka w Zamku Bierzgłowskim w 1950 r., i późniejszej działalności księży łuckich. Cały zasób archiwum został opraco­wany po przewiezieniu go do Ośrodka ABMK. Miał on charakter rozsypu, dla­tego prace inwentaryzacyjne były żmudne i długotrwałe. Opracowanie doku­mentacji fotograficznej zgodnie z metodyka archiwalną wymagało m.in. iden­tyfikacji osób, miejsc oraz daty wykonania. Aktualnie w zasobie Archiwum Diecezji Łuckiej znajdują się 434 zdjęcia, które wchodzą w skład 4 zespołów. Najwięcej fotografii znajduje się w zespole spuścizn oraz zbiorów ikonogra­ficznych. W dwóch pozostałych zespołach: Wyższe Seminarium Duchowne w Łucku i Parafia katedralna w Łucku, zdjęcia stanowią marginalną liczbę dokumentacji nieaktowej. Fotografie uwieczniają duchowieństwo katolickie diecezji i biskupów łuckich oraz budynki sakralne (kościoły i cerkwie) czy też ważne wydarzenia społeczno-religijne. Są też zdjęcia o proweniencji świec­kiej, przedstawiające m.in. Zakład Przyrodoleczniczy doktora Apolinarego Tarnawskiego w Kosowie. Zasób fotograficzny, tak jak i całe Archiwum Diecezji Łuckiej, nie jest udostępniany ze względu na stan fizyczny dokumen­tacji. Planowana jest digitalizacja całego zasobu archiwalnego i udostępnienie go w postaci cyfrowej.
A time for consolidation: A bibliometric analysis of L2 vocabulary research 1985–1989
Authors: Meara Paul
Published: December 2021

This paper uses a co-citation analysis to examine the research on L2 vocabulary acquisition that was published in 1989. Two analyses are presented. The first is a detailed account of the 1989 research on its own terms. The second analysis places this work in a larger context by looking at research published in a five-year window covering 1985–89. The analyses identify important themes in the research and significant sources who are influencing the way the research is developing at this time. The main features of this work are the substantial growth in dictionary and corpus research, and the emergence of Paul Nation as the Most Significant Source in 1989.
Emocionološki pristup suvremenoj hrvatskoj drami (na primjeru Nore danas Mire Gavrana)
Authors: Alfirević Jelena
Published: December 2021

Suvremena hrvatska psihološka drama, Gavranova Nora danas (2005.), analizirat će se iz književnoteorijskog emocionološkog aspekta. S obzirom da do sada u hrvatskoj znanosti o književnosti ne postoji pisani trag o znanstvenom radu iz područja književne emocionologije (suvremena književnoteorijska disciplina) u istraživanju hrvatske književnosti moderne i postmoderne, ovaj rad smatra se književnoznanstvenim emocionološkim prvijencem toga razdoblja. Uvodno će se prikazati teorijski okvir emocionologije s naglaskom na hrvatsku književnu znanost (godine 2012. tiskan je prvi hrvatski emocijski zbornik Poj željno). Veza između emocija i književnosti je imanentna (Brković, 2015.), a znanstveni interes rada usmjeren je na istraživanje funkcionalnosti (za)dane emocionalne kategorije dramskih likova u dramskome tekstu, u oblikovanju socijalne relacije, konkretno rodnih odnosa i literarne manifestacije emocija. Cilj je prikazati ulogu karakterističnih emocija (ljutnje, straha, tuge, radosti) u izgradnji identiteta dramskih likova Nore i Tonija (antilutke i lutka), a posebno s obzirom na rodnu stereotipizaciju. Metodologija je usmjerena na dramsku narativnu strukturu s integracijom metodoloških okvira afektivne naratologije i teorija konceptualne metafore. Analizirajući emocije kao ekspresiju osjećaja u književnom tekstu (Brković, 2015.), strategije reprezentacija emocija te recepciju emocija u suvremenoj hrvatskog drami, istražuju se suvremene koncepcije teorije književnosti ‒ emocionologije, uz doticaj kognitivne psihologije te neurobioloških i filozofskih teorija o emocijama. Novoosmišljenim pojmom emocijska metamorfoza u ovome radu želi se dati doprinos terminologiji emocionologije, koja je još uvijek neusuglašena i u razvitku (Robinson 2004, Keen 2011). Novim, emocijskim čitanjem književnog teksta sugerira se i ključ razumijevanja temeljnih odnosa (dramske) naracije, a unutar poetike suvremene (dramske) književnosti.
Pembentukkan Pusat Informasi dan Konseling Kesehatan Reproduksi Remaja (PIK-KRR) di SMPN 28 Kota Pekanbaru
Authors: Yanti  , Lailiyana
Published: December 2021

Malnutrition in toddlers is still a health problem in Indonesia. Malnutrition generally occurs in children under age 5, because at this age, children experience rapid growth. It is estimated there are still around 1.7 million children under threat of malnutrition scattered throughout Indonesia. The purpose of this community service activity is to conduct training for cadres in maternal and child health service (posyandu) about the skills in giving MP-ASI counselling in Tanah Merah village, Siak Hulu Subdistrict, Kampar Regency in 2019. The method of this activity carried out disseminating information on community service activities in the village apparatus, providing material and the practice of counselling by cadres in maternal and child health service (Posyandu). The results of this community service activities were the socialization of community service activities to village officials, the Siak Hulu Health Center and Posyandu cadres in the village office hall, followed by the provision of material for four meetings. To assess the successful implementation of community service activities, a cadre practice was conducted on the Posyandu day. Based on the results of the pre and post-test evaluations, there was an increase in cadre knowledge about the MP-ASI material. It is recommended for Posyandu cadres to apply the results of the training by activating extension activities by cadres at table V every Posyandu opening day
Branding Kota Pinta Pada Teknologi Komunikasi Tangerang Live
Authors: Abdul Basit  , Adie Dwiyanto Nurlukman
Published: December 2021

Tangerang City Government is trying to ready a smart city to provide convenience in all respects, one of which is the communication technology currently being used is the Tangerang LIVE application. Indirectly this can create good branding for the Tangerang City government. The Tangerang LIVE application has not been running as it should be, so the purpose of this research is to use this application to answer the needs and desires of the people of Tangerang City. This research was conducted with quantitative methods; this method can be answered the study's purpose. Like what the government runs this smart city through this application, the population is around Tangerang City. The study results found that smart city branding influences communication technology in the Tangerang Live application. Public services and delivery of information developed through digital communication by the Tangerang City Government are more integrated, monitored, effective, and efficient for the community
Perluasan Hutan Mangrove dalam Mitigasi Risiko Bencana Pemanasan Global: Kegiatan PkM di Kawasan Pesisir Muara Angke Jakarta
Authors: A. Maolani Rukaesih , Achmad Sudiyar Dalimunthe  , Dwi Haryanto  , Rivo Bifa  , Putri Azzahra  , Cornelia Juwita  , Putu Egawastu Suryamika
Published: December 2021

One of the disasters caused by humans is global warming. Global warming is a big problem that is being faced by all human beings and living things on earth. One of the activities that can be carried out in mitigating the risk of global warming is through Mangrove Ecosystem Rehabilitation. The existence of the Mangrove ecosystem in the coastal area of ​​DKI Jakarta Province is currently experiencing a decline in line with the development that changes the function of the area from a protected function to a cultivation function. One area that has experienced this is the coastal area in Muara Angke which has had a negative impact on the environment, namely the function of protecting and securing the coast will naturally be lost. In this 2021 Community Service program, STMA Trisakti has participated in helping to solve the problem of the rate of degradation of the Mangrove Forest by planting 1000 mangrove seedlings in the Muara Angke Eco-tourism area. The planting was carried out on World Environment Day on 5 June 2021.
Pembuatan Instalasi Sistem Pendingin Ramah Lingkungan Pada Sebuah Bengkel Pemesinan
Authors: Ndaruhadi P.Y.M. Wibowo , Saefudin Deny , Paramita V. Santi
Published: December 2021

Pandemi Covid-19 berdampak besar dalam berbagai aspek kehidupan, termasuk aspek ekonomi. Berbagai jenis usaha dan industri, khususnya yang berskala mikro dan kecil harus berstrategi menekan biaya operasional agar mampu bertahan di masa adaptasi kebiasaan baru akibat pandemi. Hal ini penting untuk meningkatkan faktor-faktor operasional produksi. Bengkel Kembang Sore merupakan salah satu bengkel permesinan kecil di Cimahi yang mengalami peningkatan tersebut. Melalui Program Kemitraan Masyarakat (PKM) 2021, perbaikan terjadi pada sistem pendingin yang digunakan dalam operasi proses pemesinan. Makalah ini membahas tentang pembuatan instalasi pendingin ramah lingkungan yang akan menggantikan sistem konvensional yang banyak menggunakan cairan pemotongan menjadi sistem yang hampir kering. Perbaikan sistem menawarkan manfaat tekno-ekonomi dan lebih sehat dan ramah lingkungan. Menurunkan biaya produksi tanpa mengurangi kinerja proses pemesinan dan kualitas produk, serta menjadikan lingkungan kerja lebih sehat dan sebagai rasa peduli terhadap lingkungan.
Peran Mahasiswa Kampus Mengajar 2 Sebagai “Agent Of Change dan Social Control”
Authors: Yorri Didit Setyadi  , Dwi Wulandari  , Lutfi Dwi Lestari  , Wa Ode Meliasari  , Ifit Novita Sari
Published: December 2021

Students are the assets of a nation because students are a group of people trained in various fields of knowledge and skills. State Junior High School 2 Tanggulangin s one of the target schools selected by the author and Ministry of Education and Culture as the place for the Kampus Mengajar 2nd  Generation as the student change agent of the education program created by us, among them the implementation of literacy learning activities and student numeration aimed at improving the understanding of literacy and student numeration. Social control is a tool to control himself or society. In this case, the society underneath is the entire State Junior High School 2 Tanggulangin  and students as the main object of Kampus Mengajar 2nd Generation activities
Penambahan Tepung Maggot Pada Pelet Tepung Komersil Terhadap Pertumbuhan Benih Ikan Patin Pangasius hypophthalmus
Authors: Mulyani Rahma , Haris Rangga Bayu Kusuma
Published: December 2021

Potensi maggot Chrysomya megacephala sebagai bahan alternatif sebagai sumber protein dapat dimaanfaatkan untuk pakan benih ikan patin Pangasius hypophthalmus. Penelitian ini dilakukan selama 2 bulan yang bertujuan untuk mengetahui laju pertumbuhan dan kelagsungan hidup benih ikan patin yang diberi pakan dengan tambahan tepung maggot dengan berbagai perlakuanÂ  yaitu perlakuan A pelet tepung (100), perlakuan B pelet dengan tepungÂ  maggot (75:25), perlakuan C pelet dengan tepung Maggot (50:50), dan perlakuan D tepung maggot (100). Hasil pengamatan menunjukkan penambahan tepung magot pada pakan menunjukkan hasil pertumbuhan berat tertinggi sebesar C 2,91 g dan terendah pada perlakuan D sebesar 1,99 g sedangkan pertumbuhan Panjang tertinggi terdapat pada perlakuan C sebesar 4,67, untuk kelangsungan hidup benih ikan patin yang memberikan nilai tertinggi sebebsar 93,3 % sehingga hasil analisis menunjukkan perlakuan B dan C berbeda nayata dengan kontrol.
Understanding sensitive cultural through daily conversation in urban society in Makassar
Authors: Basir Muhammad
Published: December 2021

This paper aims to describe how sensitive cultural may be a pattern of words and actions that should be played according to social status. This sensitive culture is ideal for each ethnic group supporting the culture. If each does not play it according to its status, it can cause misunderstanding and even conflict. Therefore, the relationship between ethnicity, immigrants, and ethnic minorities needs to be sensitive to indigenous nationalities and dominant cultural understanding. The methodology used in obtaining the data uses a qualitative approach to data collection techniques: observation and interviews. The location of the research is Makassar City, South Sulawesi, Indonesia. The results show that the city of Makassar, which is still dominated by a single ethnic group of the Bugis-Makassar to be ideal in inter-ethnic relations, uses interaction patterns of the pattern of the dominant ethnic culture or ethnic original. Thus, it should be understood by all ethnic groups who live in the city, whether its status as indigenous or tribal settlers, so that the inter-ethnic relations be harmonious. Makassar, a multi-ethnic city, is still dominated by ethnic Bugis-Makassar. At the same time, the original ethnic and cultural patterns become ideal interaction patterns in the city. As for ethnic immigrants, for example, ethnic Toraja, Mandar, Java, Ambon, Papua New Guinea, NTT, NTB, Batak, Padang, Chinese, Arabic, Padoe, and others, must understand its status as an immigrant minority, must be adaptive and be accepted in its interaction with the ethnic dominant. Therefore, as ethnic immigrants in the exchange must follow the pattern of interaction patterns in one's ideals by the dominant ethnic group, whether it be words or actions, said eg Iye, iyo, ba, iya, tabe, kita, kau, daeng, katte. Besides that, there are also rude words, namely tai laso or tai baro, nassundala’, and suntili’. It is undoubtedly susceptible when there are ethnic immigrants who do not language and act as the dominant culture because it can be considered not adaptive or do not respect an indigenous culture as a manifestation of the ideal of the dominant ethnic groups.
STUDENT’S ABILITY IN SOLVING MATH STORY PROBLEMS: GENDER DIFFERENCES
Authors: Wahyudi Ilham
Published: December 2021

Tujuan penelitian ini adalah untuk menggambarkan kemampuan penyelesaian soal cerita matematika siswa ditinjau dari perspektif gender. Jenis penelitian ini adalah penelitian deskriptif kualitatif. Subjek dalam penelitian ini adalah siswa SMPN 2 Tigo Lurah kelas VII semester 2 yang berjumlah 16 orang siswa. Materi bahasan yang digunakan adalah aritmatika sosial. Metode pengumpulan data pada penelitian ini adalah latihan soal. Teknik analisa data dalam penelitian ini adalah dengan melihat hasil latihan soal siswa dalam menyelesaikan soal cerita matematika, kemudian dikelompokkan dalam kategori rendah, sedang, dan tinggi. Hasil penelitian ini menunjukkan bahwa nilai rata-rata siswa laki-laki 82 dan nilai rata-rata siswa perempuan 75. Kesimpulan yang diperoleh dari penelitian ini adalah kemampuan penyelesaian soal cerita siswa laki-laki lebih baik dari pada siswa perempuan.
STUDENTS’ NEED ON TASK BASED LANGUAGE TEACHING WORKSHEET AT SMPN 2 TIGO LURAH BASED ON GENDER
Authors: Azani Putri Suci
Published: December 2021

This study aims to investigate students’ needs on task based language worksheet at SMPN 2 Tigo Lurah based on gender differences. This type of research was research and development research. This research targets are the seven grade students of SMPN 2 Tigo Lurah. To achieve this purpose, questionnaires and document analysis were conducted to collect the data. Data were then analyzed descriptively. Based on the need analysis result, it found that students need task based language teaching worksheet to learn English. The students need the pre-tasks task, the input of tasks and all materials stated in the curriculum. However, the differences are on the responses of the male and the female students. The female students gave high responses on the needs of task based language teaching responses than male students. Hence, the students need task based language teaching worksheet so that task based language teaching worksheet can be developed and used in the classroom.
THE REPRESENTATION OF WOMEN IN MINANGKABAU SOCIAL STRUCTURE AT TENGGELAMNYA KAPAL VAN DER WIJCK FILM
Authors: Maijar Andri , Budiman Novi , Marhen Marhen
Published: December 2021

This article aims to assess how women in the Minangkabau social structure are represented in the film Tengelamnya Kapal Vanderwijck. This study uses a qualitative descriptive method using a scientific approach to cinematography, body language, and culture to analyze the relationship between elements including setting/attributes, ceremonial costumes. This research is dissected by the theory of social structure and feminism in Minangkabau traditional culture. The analysis of this film finds that the film Tenggelammnya Kapal Vanderwijck criticizes the position of women in the form of customary rules in Minangkabau in the decision to choose a life partner, which is determined by Uncle (mamak).
Developing Criteria of an English Textbook Evaluation for Indonesian Senior High School
Authors: Munir Sirajul , Suzanne Nina , Yulnetri Yulnetri
Published: December 2021

The use of criteria of an English textbook is crucial to improve the quality of teaching. However, choosing the criteria is a challenging task for teachers and material developers. This recent study aims at developing criteria of an English textbook evaluation for Indonesian Senior High School. This research used Research and Development. Three phases were employed: exploration stage, development stage, and validation stage.  At the exploration stage, 17 respondents of English teachers were asked about the need of developing the criteria of the English textbook. All respondents agreed that the textbook evaluation criteria were needed since there is no particular standardized textbook evaluation available. Therefore, they need to use the criteria as the basis to determine the quality of a particular textbook. At the development stage, 10 criteria to evaluate textbooks were constructed. Those cover (1) aims and approaches; (2) design and organization; (3); content; (4) skills; (5) vocabulary; (6) exercises and activities; (7) methodology; (8) attractiveness of the textbook and physical make-up; (9) teacher’s manual; and (10) practical consideration. At the validation stage, the textbook evaluation criteria were deemed valid by experts. Considering these facts, 10 designed criteria could be used as the principle to determine an evaluation of English textbooks, primarily in the teaching English at Indonesian Senior High school.
Powstanie listopadowe w świetle wspomnień Erazma Rozwadowskiego
Authors: Trąbski Maciej
Published: December 2021

Like many of his contemporaries, Erazm Rozwadowski, who served as an officer in the 5th Mounted Riflemen Regiment of the Royal Polish Guard, left behind an account of his service career. Importantly, Rozwadowski only presented what he witnessed himself, in the way he remembered the event. Rozwadowski’s account includes personal details, such as his view of the uprising as seen through the eyes of a student at the Riding Cadet School, his stay at the camp of Grand Duke Konstantin near Wierzbno, and the financial difficulties he faced in order to properly equip himself upon becoming an officer.
One-Year Follow-Up of Healthy Older Adults with Electroencephalographic Risk for Neurocognitive Disorder After Neurofeedback Training
Authors: Alatorre-Cruz Graciela C. , Fernández Thalía , Castro-Chavira Susana A. , González-López Mauricio , Sánchez-Moguel Sergio M. , Silva-Pereyra Juan
Published: December 2021

Background:

In healthy older adults, excess theta activity is an electroencephalographic (EEG) predictor of cognitive impairment. In a previous study, neurofeedback (NFB) treatment reinforcing reductions theta activity resulted in EEG reorganization and cognitive improvement.

Objective:

To explore the clinical applicability of this NFB treatment, the present study performed a 1-year follow-up to determine its lasting effects.

Methods:

Twenty seniors with excessive theta activity in their EEG were randomly assigned to the experimental or control group. The experimental group received an auditory reward when the theta absolute power (AP) was reduced. The control group received the reward randomly.

Results:

Both groups showed a significant decrease in theta activity at the training electrode. However, the EEG results showed that only the experimental group underwent global changes after treatment. These changes consisted of delta and theta decreases and beta increases. Although no changes were found in any group during the period between the posttreatment evaluation and follow-up, more pronounced theta decreases and beta increases were observed in the experimental group when the follow-up and pretreatment measures were compared. Executive functions showed a tendency to improve two months after treatment which became significant one year later.

Conclusion:

These results suggest that the EEG and behavioral benefits of this NFB treatment persist for at least one year, which adds up to the available evidence contributing to identifying factors that increase its efficacy level. The relevance of this study lies in its prophylactic features of addressing a clinically healthy population with EEG risk of cognitive decline.
Design of single and double acceptance sampling plans based on interval type-2 fuzzy sets
Authors: Işık Gürkan , Kaya İhsan
Published: December 2021

Defectiveness of items is generally considered as a certain value in acceptance sampling plans (ASPs). It is clear that, it may not be certainly known in some real-case problems. Uncertainties of the inspection process such as measurement errors, inspectors’ hesitancies or vagueness of the process etc. should be taken into account to obtain more reliable results. The fuzzy set theory (FST) is one of the best methods to overcome these problems. There are some studies in the literature formulating the ASPs with the help of FST. Deciding the right membership functions of the fuzzy sets (FSs) has a vital importance on the quality of the uncertainty modeling. Additionally, the fuzzy set extensions have been offered to model more complicated uncertainties to achieve better modeling. As one of these extensions, type-2 fuzzy sets (T2FSs) gives an ability to model uncertainty in situations where it is not possible to determine exact membership function parameters. In this study, single and double ASPs based on interval T2FSs (IT2FSs) have been designed for binomial and Poisson distributions. Thus, it becomes possible to make more flexible, sensitive and descriptive sensitivity analyzes. The main characteristic functions of ASPs have been derived and the suggested formulations have been illustrated on a comparative application from manufacturing process. Results allowing for more comprehensive analysis as against to the traditional and T1FSs based plans have been obtained.
Outcomes Impacting Quality of Life in Advanced Parkinson’s Disease Patients Treated with Levodopa-Carbidopa Intestinal Gel
Authors: Kovács Norbert , Bergmann Lars , Anca-Herschkovitsch Marieta , Cubo Esther , Davis Thomas L. , Iansek Robert , Siddiqui Mustafa S. , Simu Mihaela , Standaert David G. , Chaudhuri K. Ray , Bourgeois Paul , Gao Tianming , Kukreja Pavnit , Pontieri Francesco E. , Aldred Jason
Published: December 2021

Background:

It is believed that motor symptoms, including dyskinesia, and non-motor symptoms impact health-related quality of life (HRQoL) in patients with Parkinson’s disease (PD), and that improvements in these metrics are correlated.

Objective:

Investigate the relationship between HRQoL and measures of PD severity and treatment efficacy, including motor and non-motor symptoms.

Methods:

This was a planned investigation of an international, prospective, single-arm, post-marketing observational study of the long-term effectiveness of levodopa-carbidopa intestinal gel (LCIG) in patients with advanced PD. Pearson correlation coefficients (PCC) were calculated for baseline and change from baseline at 12 months between HRQoL and motor and non-motor symptoms.

Results:

A total of 195 patients were included. At baseline, HRQoL was moderately positively correlated with Activities of Daily Living (UPDRS II, PCC = 0.44), non-motor symptoms (0.48), and measures of sleep (0.50 and 0.40); all p < 0.001. After 12 months of treatment with LCIG, improvements in HRQoL were moderately positively correlated with improvement from baseline in non-motor symptoms (PCC = 0.42), sleep (0.54), and daytime sleepiness (0.40; all p < 0.001), and weakly correlated with improvement in dyskinesia signs and symptoms (PCC = 0.23; p = 0.011). Improvement in HRQoL was not correlated with improvements in OFF time or dyskinesia time.

Conclusion:

Both at baseline and for change from baseline at 12 months, HRQoL was correlated with baseline and change from baseline in dyskinesia, Activities of Daily Living, and non-motor symptoms, including sleep; but not with baseline or change in OFF time.
Flavonoids containing Vitex negundo extract displayed calcium channels blocking property underlying its anti-diarrheal and anti-spasmodic activities
Authors: Bibi Hadia , Ali Niaz , Nabi Muhammad , Altaf Ihsan Ullah Khan , Shahid Muhammad , bukhari Syeda Hjira , Niazi Zahid Rasul , Shah Kifayat Ullah
Published: December 2021

Diarrhea is a major health problem and despite of interventions, it remains a substantial cause of mortality and morbidity. In this study, a flavonoids-rich Vitex negundo extract was mechanistically evaluated for its effectiveness in diarrheal diseases. The Vitex negundo ethanolic extract was subjected to extraction for isolation of total flavonoids and qualitative phytochemical analysis. The acute toxicity of flavonoids-extract was done in mice to assess its safety and tolerability. The anti-diarrhoeal activity was determined using the castor oil induced diarrhea mouse model at doses of 10, 30 and 100 mg/kg in relation to loperamide (10 mg/kg, oral). The antispasmodic profile was determined by using cut pieces of rabbit’s jejunum in Tyrode’s solutions, employing acetylcholine (0.03μM) as a tissue stabilizer and verapamil, as a calcium channel blocker. The preliminary qualitative analysis of extract revealed different phytochemicals, in addition to flavonoids. The acute toxicity profile showed that the flavonoids-extract is safe and tolerable (LD50 = 1678 mg/kg). In the tissue experiments, the total flavonoids exhibited an EC50 of 1.52 mg/mL and showed maximum relaxation of spontaneous contractions at 5.0 mg/mL and against high-K+ induced contractions at 3 mg/mL (EC50 = 0.43 mg/mL). The spasmolytic activity of total flavonoids was comparable to verapamil which suggests that the activity might be due to the blockade of calcium channels. The flavonoids extract (0.1, 0.3 and 1.0 mg/mL) produced an adequate right shift in the calcium concentration response curve as compared to the control (EC50 value = –2.67 mg/mL), which confirmed that the extract has calcium channel blocking activity.
Combining antibiotics with silver nanoparticles: A potential treatment strategy against antimicrobial resistance
Authors: Afridi Maryam , Khan Saeed Ahmad , Afridi Ruqayya , Ullah Farman , Majid Abdul , Khan Aziz Ahmad , Ali Nawab
Published: December 2021

Growing resistance to currently approved antibiotics is posing serious concern worldwide. The multidrug-resistant organisms are a major cause of mortality and morbidity around the globe. The limited options to treat infections caused by resistant organism requires alternative strategies to increase the effectiveness of antibiotic for better clinical outcomes. Recent advances in nanotechnology have enabled the drugs to be used in nanoscale to increase the effectiveness of antibiotics. The use of nanoparticles to treat infectious diseases has a long history in the pharmaceutical market, and the versatility of these particles to incorporate various materials as carriers make it an attractive option to combat the current crisis of emerging antibacterial resistance. Silver, a metal with many medical applications, has inherent antimicrobial properties. Therefore, silver NPs are appearing as one of the best options to be used in combination with antibiotics to increase effectiveness against resistant bacteria. Here, we discuss the applications and mechanisms of silver NPs to treat microbial resistance in light of recent research.
Structural analysis of dexrazoxane: Exploring tautomeric conformations
Authors: Behboodyzad Farnoosh , Mohseniabbasabadi Tahereh , Ghanemnia Nahal , Balali Ebrahim
Published: December 2021

Structural analysis of dexrazoxane, as a cardioprotective agent, was done in this work by exploring formations of tautomeric conformations and investigating the corresponding effects. Density functional theory (DFT) calculations were performed to optimize the structures to evaluate their molecular and atomic descriptors. In addition to the original structure of dexrazoxane, eight tautomers were obtained with lower stability than the original compound. Movements of two hydrogen atoms in between nitrogen and oxygen atoms of heterocyclic ring put such significant effects. Moreover, electronic molecular orbital features showed effects of such tautomerism processes on distribution patterns and surfaces, in which evaluating the quadrupole coupling constants helped to show the role of atomic sites for resulting the features. As a consequence, the results indicated that the tautomeric formations could significantly change the features of dexrazoxane reminding the importance of carful medication of this drug for patients.
L-Carnitine prevents memory impairment induced by post-traumatic stress disorder
Authors: Alzoubi Karem H. , Al-Dekah Arwa M. , Jaradat Saied , Alrabadi Nasr
Published: December 2021

Background:

Post-traumatic stress disorder (PTSD) is a genuine obstructing mental disorder. As indicated by the name, it is related to the patients’ stress augmented by life-threatening conditions or accidents. The PTSD has linked to oxidative stress that can result in neurodegeneration. L-carnitine (L-CAR) is known for its antioxidant properties, which can protect against neuronal damage.

Objective:

In the current study, we investigated the beneficial effects of L-CAR on the memory impairment induced by PTSD using a rat model.

Methods:

A model of single-prolonged stress (a cycle of restraining, forced swimming, rest, and finally diethyl ether exposure for 2 h, 20 min, 15 min, and 1–2 min, respectively) was used to induce PTSD-like behavior. Intraperitoneal L-CAR treatment (300 mg/kg/day) was introduced for four weeks. Both memory and special learning were evaluated utilizing the radial arm water maze (RAWM). Moreover, the levels of glutathione peroxidase (GPx), glutathione reduced (GSH), and glutathione oxidized (GSSG) were assessed as biomarkers oxidative stress in the hippocampus.

Results:

The results demonstrated that both the short and long-term memories were impaired by PTSD/SPS model ( P < 0.05), while L-CAR treatment prevented this memory impairment in PTSD rats. Besides, L-CAR prevented the reduction in GPx activity and increase in GSSG, which were altered in the hippocampus of the PTSD/SPS rats ( P < 0.05). Levels of GSH were not changed in PTSD and/or L-CAR rats.

Conclusions:

L-CAR administration prevented short- and long-term memories’ impairments induced in the PTSD/SPS rat model. This is probably related to its antioxidant effects in the hippocampus.
Combined transcranial Direct Current Stimulation and robot-assisted arm training in patients with stroke: a systematic review
Authors: Fonte Cristina , Varalta Valentina , Rocco Arianna , Munari Daniele , Filippetti Mirko , Evangelista Elisa , Modenese Angela , Smania Nicola , Picelli Alessandro
Published: December 2021

Background:

Upper limb motor deficits in patients with severe stroke often remain unresolved over time. Combining transcranial Direct Current Stimulation with robotic therapy is an innovative neurorehabilitation approach that holds promise to improve upper limb impairment after stroke.

Objective:

To investigate the effects of robotic training in combination with transcranial Direct Current Stimulation for treating poststroke upper limb impairment.

Methods:

PubMed, MEDLINE, Cochrane Library, and EMBASE electronic databases were searched using keywords, MeSH terms, and strings: “Stroke”[MeSH] AND (“Upper Extremity”[MeSH] OR “upper limb”) AND (“Transcranial Direct Current Stimulation” [MeSH] OR “tDCS”) AND (“robotics” OR “robotic therapy”). Full-text articles published in English up to October 2020 were included. Each was rated for quality according to the Physiotherapy Database (PEDro) score: eight out of eleven scored more than 8 points; their results were considered reliable for this review.

Results:

Of the total of 171 publications retrieved, 11 met the inclusion criteria. The results of studies that examined the same outcome measures were pooled to draw conclusions on the effectiveness of transcranial Direct Current Stimulation and robot-assisted training in corticomotor excitability, upper limb kinematics, muscle strength and tone, function, disability, and quality of life after stroke.

Conclusions:

To date, there is insufficient evidence to support the hypothesis that transcranial Direct Current Stimulation enhances the effects of robot-assisted arm training in poststroke patients. Further studies with more accurate, comparable and standardized methodology are needed in order to better define the effects of robotic training in combination with transcranial Direct Current Stimulation on poststroke upper limb impairment. Therefore, given the scarce resources available to rehabilitation researches, other, more promising approaches should be given attention.
THE RESPONSE OF PESANTREN COMMUNITY IN MAGELANG TO THE IMPLEMENTATION OF MEASLES RUBELLA VACCINATION
Authors: Mahsun Mahsun , Abdillah Junaidi , Munji Ahmad
Published: December 2021

This research is motivated by the pros and cons of the Measles Rubella vaccination program among Islamic boarding schools in Magelang, Indonesia. The aim was to find out the response of the Pesantren  community in Magelang, Indonesia as a representative of the Muslim community to the Measles Rubella (MR) vaccination law in 2017. Moreover, this paper was focused on the investigation for the elements that is influencing the emergence of pros and cons attitudes among the Pesantren  community and interfaith communities in Magelang, Indonesia toward the MR vaccination law. The scope of the study is to analyze the opinion of the ulama holding the Pesantren  and interfaith communities about the law of MR vaccination. The author used a sociology approach. Data obtained through observation, interview and literature study. The author used deductive-inductive methods and critical reflection to analyze the data. The article presents the conclusion of research that the Pesantren  communityresponse in Magelang to inplementation of vaccination occurred pros and cons. Groups who reject vaccination argue that vaccination is against religious law. Meanwhile, the group receiving vaccination argues that it is important and emergencies in ensuring the health of children to avoid the disease that will result from not being immunized. So is the perspective of world religions. Essentially Islam, Protestant, Hindu received vaccination as an effort to ensure the health of children. While Catholics and Buddhism tend to reject vaccination.
ГЕРМЕНЕВТИЧЕСКИЙ ПОДХОД К ПРОФЕССИОНАЛЬНОЙ ПОДГОТОВКЕ ВЫПУСКНИКОВ ТВОРЧЕСКИХ ВУЗОВ
Authors:   Алтайский государственный институт культуры, Жерносенко Ирина , Кузнецова Ольга ,   Алтайский государственный институт культуры
Published: December 2021

Поднимается проблема метода исследования, который учитывал бы специфику наук об искусстве. В качестве такого метода предлагается рассматривать герменевтическую логику с ее интерпретационными и «понимающими» приемами. Обращение авторов статьи к данной методологии позволило рассматривать художественные произведения как «тексты» с «прочтением» и «пониманием» их глубинных смыслов. Актуализируется использование герменевтического подхода в современном гуманитарном и творческом образовании в высшей школе, как наиболее адекватно отвечающего глобальным вызовам современности, способствующего преодолению клипового сознания современной молодёжи и становлению целостного мировосприятия. Подробно прописан алгоритм применения метода герменевтической логики, ядром которого является «герменевтический круг», инициирующий нелинейный процесс постижения многоуровневых смыслов произведений искусства. Рассмотрена диалоговая природа герменевтического подхода в образовании, эффективно применяемого как в познавательной, так и в исследовательской практике студентов.
CLINICAL FEATURES OF ANXIETY DISORDER IN POST-COVID-19 SYNDROME AND FINDING OF ITS PREDICTORS
Authors: Boiko Dmytro
Published: December 2021

the article summarizes and describes clinical features of anxiety disorders in post-COVID-19 syndrome. Mental and neurological disorders occupy a leading place in the structure of post-COVID syndrome. Recent studies indicate an increase in the incidence of anxiety disorders in individuals with COVID-19. However, no clinical or laboratory features of the post-COVID anxiety disorders have been identified. Therefore, our study aimed to describe the clinical features of anxiety disorders in the post-COVID period and to develop a mathematical prognostic model to identify potential predictors of post-COVID anxiety disorder. We conducted a case-control clinical study, which included 145 males and females, which were divided into 2 groups, namely: group 1 - patients who became ill with COVID-19 during the last 6 months and group 2 - persons who were not ill with COVID-19 during the last 6 months. The clinical interview included the registration of symptoms of the debut and the time of the debut relative to the episode of COVID-19. The Beck anxiety inventory was used for the assessment of the overall level of anxiety. The State-trait anxiety inventory was used to assess  state and trait anxiety. Statistical analysis of the data was performed using the program EZR Statistics 1.54. Anxiety disorders during the first 6 months after COVID-19 develop more often than those who have not had the disease in the last six months. Patients who had COVID-19 in the last 5-24 weeks have an increased risk of anxiety disorders during this period and therefore require close medical supervision and sufficient awareness of the likely symptoms. People with a post-COVID anxiety disorder reported the presence of autonomic symptoms, including excessive sweating and tachycardia, a feeling of inner emptiness, as well as circadian rhythm disorders in the form of difficulty falling asleep and waking up at the desired time. It should be noted that the overall frequency of detection of anxiety disorders in the post-COVID period is increasing. It has been established that the risk of developing post-COVID disorder decreases with knowledge of the fact of contact with an infected person before the COVID onset  and increases with a heightened level of prior personal anxiety. Circadian rhythm disorders, in particular sleep phase shift and abnormal fatigue, may be predictors of post-COVID anxiety disorder.
MORPHOLOGICAL CHANGES IN SOFT PALATINE TISSUES STANDING BEHIND OBSTRUCTIVE SLEEP APNEA SYNDROME: GENERAL PATTERN AND ROLE OF HUMAN PAPILLOMA VIRUS
Authors: Denysenko Roman , Gychka Sergiy , Nikolaienko Sofia , Dikhtiaruk Oleksandr , Naumenko Oleksandr
Published: December 2021

snoring and obstructive sleep apnea syndrome (OSAS) are a serious medical problem, as they lead to a complex of complications from various body systems, disrupt the socio-economic sphere and stigmatize patients. To date, a set of treatments has been developed, the most effective of which are conservative therapy using CPAP and surgical interventions - various modifications of uvulopalatopharyngoplasty. However, only a small number of studies have elucidated soft palate tissue pathology in patients with chronic and OSAS. But understanding the morphological changes is one of the key aspects for the development of treatment tactics. The aim of current study is to justify the choice of surgical intervention in the treatment of snoring and OSAS by description of morphological changes of the soft palate and to estimate the impact of HPV infection on the progression of soft palatine remodeling. The study included soft palatine tissue samples, which were removed during surgery for snoring and OSAS in 15 patients. Histological (H&E) and immunohistochemical techniques (Ki-67, p16, Human Papilloma Virus). All patients were divided in two groups according HPV-positivity: 5 persons in HPV-positive group and 10 persons in HPV-negative group. For indicators were estimated: number of cellular layers (CL), number of intraepithelial lymphocytes (per 100 epitheliocytes) (IEL), number of vessels per x100 field (NV), Ki-67 proliferation index (PI). Results shows in HPV+ group: CL - 24,2 (±2,17); IEL - 37,8 (±20,97), NV - 21 (±8,46); PI - 17,6 (±2,51). In HPV- group: CL - 6 (±4,78); IEL - 3,3 (±1,77); NV - 10,7 (±2,67); PI - 7,3 (±2,71). Mann-Whitney criterion shows statistical significant difference between groups for all mentioned indicators.  In conclusion: patients with snoring and obstructive sleep apnea syndrome had hypertrophy of the soft palate structures caused by changes in epithelial and connective tissue components. Subepithelial structures underdo the disorganization of connective tissue components with a violation of the histoarchitectonics of collagen fibers, edema and angiomatosis. Thus, the study revealed a number of irreversible pathological processes of soft palate tissues, which is the basis for the choice of surgical treatment tactics including the resection of excess tissue. At the same time HPV-infection leads to more pronounced changes in the epithelial layer and subepithelial tissue with concomitant inflammation that likely to create a negative background for further treatment of OSA syndrome.
FAMILIAL MEDITERRANEAN FEVER COMPLICATED BY CHRONIC KIDNEY DISEASE STAGE 5 DESCRIPTION OF THE CLINICAL CASE
Authors: Palchukovska Maria , Liksunova Lyudmila
Published: December 2021

this clinical case demonstrates renal amyloidosis – the most severe complication of familial Mediterranean fever (FMF). This clinical case gives an example of rapid evolution of renal failure in the lack of treatment. 62 years old man, Armenian, consults  a physician with such complaints as evening fever up to 38° for a month, frequent urination and dark urine. Biochemical blood test revealed an increase in the following indices: creatinine-489 μmol / l, urea 28.3 μmol / l, uric acid 619 μmol / l. GFR-6ml / min. No amyloid deposits were detected by biopsy of the buccal mucosa. The diagnosis of FMF, chronic kidney disease (CKD) stage 5. Initiation of treatment. Tenkhoff catheter installation. Treatment includes сontinuous ambulatory peritoneal dialysis (CAPD) in mode 4 exchanges with a glucose solution of 1.36% 2.0 liters. The dynamics of treatment is positive in  presence of constant replacement therapy. A feature of this clinical case is the insidious development of secondary (AA) amyloidosis in uncontrolled patient, which leads to the development of end-stage chronic kidney disease (CKD). This case demonstrates the need of constant examination and treatment of the patients with end-stage CKD by renal replacement therapy, which significantly reduces the quality of patient`s life.
CHARACTERISTICS AND SUBSTANTIATION OF THE USE OF PELLETS AS A MODERN DOSAGE FORM ON THE MARKET OF UKRAINE
Authors: Yerkhova Anna , Katynska Maryna
Published: December 2021

currently, omeprazole pellets are one of the most common pellet formulations on the pharmaceutical market of Ukraine (Gorobets, Matyash, Pekhenko & Barna, 2019). This medication is available in capsule form. Pellets are multi particular dosage forms that have several advantages over monoparticular dosage forms; therefore, pellets are promising oral delivery systems for active pharmaceutical ingredients (APIs). Pellets are used when the stability of the active substance changes with fluctuations in the pH of the environment, when irritation of the gastric mucosa is possible, to facilitate swallowing (especially important for patients with dysphagia, elderly patients, and children). When using polymers in the shell, it is possible to regulate the release in a certain part of the gastrointestinal tract, this allows you to get a point pharmacological effect. In addition, pellets can be of different sizes (from 0.1 to 2 mm), because of their shape, pellets exhibit abrasion resistance and are more fluid. Omeprazole is a synthetic substance. The active ingredient suppresses gastric acid secretion. In refers to the pharmaceutical group of proton pump inhibitors, it prescribes drugs in this group to treat active duodenal ulcers, gastric ulcers, gastro-oesophageal reflux disease (GERD), severe erosive esophagitis, pathological hypersecretory conditions, for example, Zollinger Ellison syndrome. Among the most commonly used methods for the production of pellets are: stage-by-stage spraying of solutions or suspensions (the second name is stage-by-stage layering); direct pelletization (the second name is extrusion-spheronization); spray drying and spray cooling of melts; agglomeration-spheronization. Unfortunately, at the moment, none of the Ukrainian manufacturers is manufactured enteric pellets on their own (they buy ready-made pellets), while there are medicines of both foreign and Ukrainian origin on the domestic market. The article contains an overview of pharmaceutical preparations as pellets, systematization of information on production methods, a review of omeprazole drugs as pellets, presented on the pharmaceutical market of Ukraine. The purpose of this study was to summarize the cases when the use of such a form as pellets is the most reasonable; make an overview of medicines in Ukraine containing pellets; summarize modern methods of pellet production.
Optimum Time and Temperature for Biodiesel Production using Melon (Cucumeropsismannii), Groundnut (Arachis Hypogea), and Soybean (Glycine max)
Authors: Onyenze Ugochukwu , Igwe Jude Chibuzo , Sonde Christopher Uchechukwu , Udo Philip Edidiong , Ogwuda Uche Anthony , Edozie Otuokere Ifeanyi
Published: December 2021

This study investigated the optimum condition for biodiesel production at varying temperatures and time using melon (Cucumeropsismannii), groundnut (Arachis hypogea), and soybean (Glycine max) seed oils. Oil was extracted from Cucumeropsismannii, A. hypogea, and G. max using n-hexane(67.7-69.2oC) as the solvent. Biodiesel was produced from three different seed oils at varying temperatures of 65oC, 55oC, and 45oC at varied durations of 60mins, 50mins, and 40mins. The best percentage yield was obtained at 65oC for the duration of 60 minutes. The transesterification process was not complete at 40 min; however, at 50 min the process was completed. The process also remained incomplete at 45oC.The maximum percentage yield of biodiesel obtained through transesterification was 90.83% for G. max, 78.00%for A. hypogea, and 77.58% for Cucumeropsismannii seedoils. Fuel properties of biodeisels, such as kinematic viscosity, pour point, carbon residue, cloud point, water content, flash point, cetane index, and sulfated ash, were examined. The flashpoint, carbon residue, kinematic viscosity, and water content of biodiesels were within the standard specified for petrol diesel; however, cloud point and pour points of this product were found to be greater than that of petrol diesel. The cetane index of biodiesels was lower than the standard specified for petrol diesel. Additionally, the samples were not found to contain sulfated ash. Therefore, Cucumeropsismannii, A. hypogea), and G. max are goodsources of biodiesel production.
Keywords
biodiesel, energy, environment, fuel properties, renewable fuel
Copyright (c) The Authors
Discursos do Corpo na Arte - Volume III
Authors: Farias Tavares Enéias , Reis Biancalana Gisela , Magno Mariane
Published: December 2021

Ao unir Corpo e Arte pela via do discurso e da ciência, sob a pluralidade de perspectivas conceituais, nos conectamos, em determinados tempos e espaços sem, no entanto, desconectar-nos da imensidão do ser, da imensidão poética e da imensidão reflexiva, igualmente inesgotáveis.