bluuebunny/crossref_metadata_2025 huggingface dataset:
Efficiency and Mechanism Evaluation of Magnolia officinalis Water Extract in Preventing Gastric Ulcer
Authors: Shen Kuo-Ping , Chang Ching-Dong , Hsieh Meng-Hsun , Chaung Hso-Chi
Published: April 2023

In this study we aimed at demonstrating the ability of Magnolia officinalis water extract to ameliorate gastric ulcers in in vitro and in vivo experiments. The gastric mucosa epithelial cell line, RGM 1, was pretreated with Magnolia officinalis water extract (0, 0.1, 1, 2, 5, or 10 mg/ml) and cultured in DMEM/F12 medium (pH 7.4) for 2 h and then in DMEM/F12 medium (pH 4.0) for 10 min. Magnolia officinalis water extract protected the cell viability and decreased reactive oxygen species formation by the acidic medium. In the in vivo experiment, Magnolia officinalis water extract (100 mg/kg) was administrated daily for 28 days in ICR mice via oral gavage, and then Shay’s ulcer surgical method was performed to induce gastric ulcers. We analyzed the pH value of stomach acid and the pathological section, inflammation, and cannabinoid receptor type 2 (CB2) cDNA levels of the stomach. Magnolia officinalis water extract not only enhanced the pH value of stomach acid but also ameliorated the ulcer index and inflammation and increased CB2 expression effectively. These results suggest that Magnolia officinalis water extract might be used to decrease the incidence of gastric ulcer.
Numerical Study of Acoustic‐Electric Signal Conversion for GIS Discharge Detection and Structure Optimization for pMUT
Authors: Si Wen-Rong , Zhao Ying-Ying , Hu Zheng-Yong , Fu Chen-Zhao , Wang Bo , Yang Jian
Published: April 2023

With the development of microelectromechanical technology, the piezoelectric micromechanical ultrasonic transducer (pMUT) for ultrasonic detection of gas‐insulated switchgear (GIS) breakdown discharge has become possible. In this article, the ultrasonic‐solid‐pMUT coupling simulation model was established to investigate the propagation process of ultrasonic waves in GIS enclosure and the conversion between ultrasonic and electric signals through pMUT. The output electric signals for the unsimplified top electrode and simplified top electrode model were compared, and the structure of receiving pMUT was optimized according to the main ultrasonic frequency range of GIS breakdown discharge and the key performance parameters of pMUT. First, it is found that the simulation results of the ultrasonic‐solid‐pMUT coupling model are reliable, and the frequency of the output electric signal of receiving pMUT is consistent with the input signal, while the amplitude of output signal attenuates greatly. Second, simplifying the top electrode of pMUT may lead to relatively large errors in simulation results. The output response of simplified pMUT is obviously weakened, and the inherent frequency is higher. Furthermore, it is noted that the pMUT inherent frequency (f0) is inversely proportional to the radius (R) of the piezoelectric layer and directly proportional to the substrate thickness (dsi). When the coverage rate of the top electrode is between 30% and 80%, the pMUT effective electromechanical coupling coefficient () is high and has a maximum value. Finally, it is indicated that the pMUT with the optimum structure is suitable for the detection of GIS breakdown discharge ultrasonic signals, and the can be improved by 106.7%.
Supplementary File from Heterogeneity of Circulating Tumor Cell–Associated Genomic Gains in Breast Cancer and Its Association with the Host Immune Response
Authors: Kanwar Nisha , Balde Zaldy , Nair Ranju , Dawe Melanie , Chen Shiyi , Maganti Manjula , Atenafu Eshetu G. , Manolescu Sabrina , Wei Carrie , Mao Amanda , Fu Fred , Wang Dan , Cheung Alison , Yerofeyeva Yulia , Peters Rachel , Liu Kela , Desmedt Christine , Sotiriou Christos , Szekely Borbala , Kulka Janina , McKee Trevor D. , Hirano Naoto , Bartlett John M.S. , Yaffe Martin J. , Bedard Philippe L. , McCready David , Done Susan J.
Published: April 2023

Raw cell counts of FISH gene probes for (1) primary breast tumors, (2) metastatic sites, (3) pre- and post-treatment [Hungarian sample], and (4) TNBC cases.
Supplementary Data from Transcriptional Reprogramming Differentiates Active from Inactive ESR1 Fusions in Endocrine Therapy-Refractory Metastatic Breast Cancer
Authors: Gou Xuxu , Anurag Meenakshi , Lei Jonathan T. , Kim Beom-Jun , Singh Purba , Seker Sinem , Fandino Diana , Han Airi , Rehman Saif , Hu Jianhong , Korchina Viktoriya , Doddapaneni Harshavardhan , Dobrolecki Lacey E. , Mitsiades Nicholas , Lewis Michael T. , Welm Alana L. , Li Shunqiang , Lee Adrian V. , Robinson Dan R. , Foulds Charles E. , Ellis Matthew J.
Published: April 2023

It includes Supplementary Methods, Supplementary Figures, Supplementary Tables, and Supplementary References
Data from Longitudinal SARS-CoV-2 mRNA Vaccine-Induced Humoral Immune Responses in Patients with Cancer
Authors: Figueiredo Jane C. , Merin Noah M. , Hamid Omid , Choi So Yung , Lemos Tucker , Cozen Wendy , Nguyen Nathalie , Finster Laurel J. , Foley Joslyn , Darrah Justin , Gong Jun , Paquette Ronald , Mita Alain C. , Vescio Robert , Mehmi Inderjit , Basho Reva , Tourtellotte Warren G. , Huynh Carissa A. , Melmed Gil Y. , Braun Jonathan , McGovern Dermot P.B. , Mengesha Emebet , Botwin Greg , Prostko John C. , Frias Edwin C. , Stewart James L. , Joung Sandy , Van Eyk Jennifer , Ebinger Joseph E. , Cheng Susan , Sobhani Kimia , Reckamp Karen L. , Merchant Akil
Published: April 2023

Abstract
Longitudinal studies of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine-induced immune responses in patients with cancer are needed to optimize clinical care. In a prospective cohort study of 366 (291 vaccinated) patients, we measured antibody levels [anti-spike (IgG-(S-RBD) and anti-nucleocapsid immunoglobulin] at three time points. Antibody level trajectories and frequency of breakthrough infections were evaluated by tumor type and timing of treatment relative to vaccination. IgG-(S-RBD) at peak response (median = 42 days after dose 2) was higher (P = 0.002) and remained higher after 4 to 6 months (P = 0.003) in patients receiving mRNA-1273 compared with BNT162b2. Patients with solid tumors attained higher peak levels (P = 0.001) and sustained levels after 4 to 6 months (P < 0.001) compared with those with hematologic malignancies. B-cell targeted treatment reduced peak (P = 0.001) and sustained antibody responses (P = 0.003). Solid tumor patients receiving immune checkpoint inhibitors before vaccination had lower sustained antibody levels than those who received treatment after vaccination (P = 0.043). Two (0.69%) vaccinated and one (1.9%) unvaccinated patient had severe COVID-19 illness during follow-up. Our study shows variation in sustained antibody responses across cancer populations receiving various therapeutic modalities, with important implications for vaccine booster timing and patient selection.
Significance:
Long-term studies of immunogenicity of SARS-CoV-2 vaccines in patients with cancer are needed to inform evidence-based guidelines for booster vaccinations and to tailor sequence and timing of vaccinations to elicit improved humoral responses.
Supplementary Figure S8 from Interethnic Differences in Bladder Cancer Incidence and the Association Between Type 2 Diabetes and Bladder Cancer in the Multiethnic Cohort Study
Authors: Bogumil David , Cortessis Victoria K. , Wilkens Lynne R , Le Marchand Loic , Haiman Christopher A , Maskarinec Gertraud , Setiawan Veronica Wendy
Published: April 2023

Supplementary Figure 8: Association between Any T2D and BCA stratified by sex and race/ethnicity. Models adjusted for pack-years
smoked (0, 1-10, 11-20, 21-30, 31-40, >40), alcohol consumption (<1 drinks/month, ≤1 drinks/day, >1 drinks/day), sex (male, female),
number of cigarettes smoked per day among smokers (5 cigarettes or less, 6-10 cigarettes, 11-20, 21-30, 31 or more), race/ethnicity
(European American, African American, Japanese American, Latin American, Native Hawaiian), and reproductive factors among
females. Body mass index (BMI, kg/m3
) and smoking status (ever, never, current) were included as strata variables due to their
proportional hazard violation. Categorical birth year was also included as a strata variable to adjust for possible cohort effects. CI:
Confidence Interval; HR: Hazard Ratio; P het: P- heterogeneity for likelihood ratio test for difference in association by sex.
Supplementary Figure S7 from Interethnic Differences in Bladder Cancer Incidence and the Association Between Type 2 Diabetes and Bladder Cancer in the Multiethnic Cohort Study
Authors: Bogumil David , Cortessis Victoria K. , Wilkens Lynne R , Le Marchand Loic , Haiman Christopher A , Maskarinec Gertraud , Setiawan Veronica Wendy
Published: April 2023

Supplementary Figure 7: Association between T2D and BCA in the multiethnic sample and by race/ethnicity, stratified by T2D
assessment method, restricted to MEC participants with Medicare FFS enrollment. Models adjusted for pack-years smoked (0, 1-10,
11-20, 21-30, 31-40, >40), alcohol consumption (<1 drinks/month, ≤1 drinks/day, >1 drinks/day), sex (male, female), number of
cigarettes smoked per day among smokers (5 cigarettes or less, 6-10 cigarettes, 11-20, 21-30, 31 or more), race/ethnicity (European
American, African American, Japanese American, Latin American, Native Hawaiian), and reproductive factors among females. Body
mass index (BMI, kg/m3
) and smoking status (ever, never, current) were included as strata variables due to their proportional hazard
violation. Categorical birthyear was also included as a strata variable to adjust for possible cohort effects. CI: Confidence Interval; HR:
Hazard Ratio; P het: P- heterogeneity for likelihood ratio test for difference in association across race/ethnicity groups.
Supplementary Figure S10 from Interethnic Differences in Bladder Cancer Incidence and the Association Between Type 2 Diabetes and Bladder Cancer in the Multiethnic Cohort Study
Authors: Bogumil David , Cortessis Victoria K. , Wilkens Lynne R , Le Marchand Loic , Haiman Christopher A , Maskarinec Gertraud , Setiawan Veronica Wendy
Published: April 2023

Supplementary Figure 10: Association between Any T2D and BCA, stratified by race/ethnicity and SEER stage. SEER stage. 0: In situ:
noninvasive, intraepithelial; 1: Localized only; 2: Regional by direct extension only; 3: Regional lymph node(s) involved only; 4: Regional
by BOTH direct extension AND regional lymph node(s) involved; 5: Regional, NOS; 7: Distant site(s)/lymph node(s) involved; 8:
Unknown if extension or metastasis. Models adjusted for pack-years smoked (0, 1-10, 11-20, 21-30, 31-40, >40), alcohol consumption
(<1 drinks/month, ≤1 drinks/day, >1 drinks/day), sex (male, female), number of cigarettes smoked per day among smokers (5 cigarettes
or less, 6-10 cigarettes, 11-20, 21-30, 31 or more), race/ethnicity (European American, African American, Japanese American, Latin
American, Native Hawaiian), and reproductive factors among females. Body mass index (BMI, kg/m3
) and smoking status (ever, never,
current) were included as strata variables due to their proportional hazard violation. Categorical birthyear was also included as a strata
variable to adjust for possible cohort effects. CI: Confidence Interval; HR: Hazard Ratio.
Supplemental Figure 3 from Treatment Patterns and Outcomes of Preoperative Neoadjuvant Radiotherapy in Patients with Early-onset Rectal Cancer
Authors: Badesha Jasleen K. , Zhou Marilyn , Arif Arif A. , Gill Sharlene , Speers Caroline , Peacock Michael , De Vera Mary A. , Stuart Heather C. , Brown Carl J. , Donellan Fergal , Loree Jonathan M.
Published: April 2023

Supplemental Figure 3. Kaplan Meier curves for locoregional recurrence (LRR) in (A) early-onset and average-onset patients, (B) early-onset decile groups, and (C) early-onset and average-onset patients that received long-course chemoradiotherapy or (D) short-course radiotherapy.
Supplemental Figure 2 from Treatment Patterns and Outcomes of Preoperative Neoadjuvant Radiotherapy in Patients with Early-onset Rectal Cancer
Authors: Badesha Jasleen K. , Zhou Marilyn , Arif Arif A. , Gill Sharlene , Speers Caroline , Peacock Michael , De Vera Mary A. , Stuart Heather C. , Brown Carl J. , Donellan Fergal , Loree Jonathan M.
Published: April 2023

Supplemental Figure 2. (A) Overall clinical stage and (B) overall pathological stage distribution stratified by age.
Data from Interethnic Differences in Bladder Cancer Incidence and the Association Between Type 2 Diabetes and Bladder Cancer in the Multiethnic Cohort Study
Authors: Bogumil David , Cortessis Victoria K. , Wilkens Lynne R , Le Marchand Loic , Haiman Christopher A , Maskarinec Gertraud , Setiawan Veronica Wendy
Published: April 2023

Abstract
Background: Research on the association between type 2 diabetes (T2D) and bladder cancer (BCA) risk among non-European ancestry populations is sparse to non-existent, and most prior studies rely on a single baseline assessment of T2D status.
Methods: We estimated the T2D – BCA association using the Multiethnic Cohort Study of 185,059 men and women in California and Hawaii. Participants were African American, European American, Japanese American, Latin American, and Native Hawaiian, aged 45-75 years at enrollment (1993-1996). T2D was assessed by self-report at baseline, follow-up surveys, and Medicare claims. Cases were identified using SEER cancer registries through 2016. Associations were estimated by race/ethnicity using Cox proportional hazards regression. Adjusted attributable fractions (AAFs) and cumulative absolute risk of BCA were estimated across groups.
Results: Over an average 19.7 years of follow-up 1,890 incident BCA cases were diagnosed. Time-varying T2D was associated with BCA in the multiethnic sample (HR=1.17, 95% CI, 1.05, 1.30), however the hazard ratio did not differ by race/ethnicity (p=0.85). The AAF was 4.2% in the multiethnic sample and largest among Native Hawaiians (9.8%). Absolute risk of BCA among European Americans without T2D was higher than all other groups with T2D.
Conclusion: T2D is significantly associated with BCA risk in a multiethnic sample.
Data from Ultra High-plex Spatial Proteogenomic Investigation of Giant Cell Glioblastoma Multiforme Immune Infiltrates Reveals Distinct Protein and RNA Expression Profiles
Authors: Bonnett Shilah A. , Rosenbloom Alyssa B. , Ong Giang T. , Conner Mark , Rininger Aric B.E. , Newhouse Daniel , New Felicia , Phan Chi Q. , Ilcisin Saskia , Sato Hiromi , Lyssand John S. , Geiss Gary , Beechem Joseph M.
Published: April 2023

A deeper understanding of complex biological processes, including tumor development and immune response, requires ultra high-plex, spatial interrogation of multiple “omes”. Here we present the development and implementation of a novel spatial proteogenomic (SPG) assay on the GeoMx Digital Spatial Profiler platform with next-generation sequencing readout that enables ultra high-plex digital quantitation of proteins (>100-plex) and RNA (whole transcriptome, >18,000-plex) from a single formalin-fixed paraffin-embedded (FFPE) sample. This study highlighted the high concordance, R > 0.85 and <15% change in sensitivity between the SPG assay and the single-analyte assays on various cell lines and tissues from human and mouse. Furthermore, we demonstrate that the SPG assay was reproducible across multiple users. When used in conjunction with advanced cellular neighborhood segmentation, distinct immune or tumor RNA and protein targets were spatially resolved within individual cell subpopulations in human colorectal cancer and non–small cell lung cancer. We used the SPG assay to interrogate 23 different glioblastoma multiforme (GBM) samples across four pathologies. The study revealed distinct clustering of both RNA and protein based on pathology and anatomic location. The in-depth investigation of giant cell glioblastoma multiforme (gcGBM) revealed distinct protein and RNA expression profiles compared with that of the more common GBM. More importantly, the use of spatial proteogenomics allowed simultaneous interrogation of critical protein posttranslational modifications alongside whole transcriptomic profiles within the same distinct cellular neighborhoods.
Significance:
We describe ultra high-plex spatial proteogenomics; profiling whole transcriptome and high-plex proteomics on a single FFPE tissue section with spatial resolution. Investigation of gcGBM versus GBM revealed distinct protein and RNA expression profiles.
Interethnic Differences in Bladder Cancer Incidence and the Association between Type 2 Diabetes and Bladder Cancer in the Multiethnic Cohort Study
Authors: Bogumil David , Cortessis Victoria K. , Wilkens Lynne R. , Le Marchand Loïc , Haiman Christopher A. , Maskarinec Gertraud , Setiawan Veronica Wendy
Published: April 2023

Background:

Research on the association between type 2 diabetes (T2D) and bladder cancer (BCA) risk among non-European ancestry populations is sparse to nonexistent, and most prior studies rely on a single baseline assessment of T2D status.

Methods:

We estimated the T2D-BCA association using the Multiethnic Cohort Study of 185,059 men and women in California and Hawaii. Participants were African American, European American, Japanese American, Latin American, and Native Hawaiian, ages 45–75 years at enrollment (1993–1996). T2D was assessed by self-report at baseline, follow-up surveys, and Medicare claims. Cases were identified using Surveillance, Epidemiology and End Results Program cancer registries through 2016. Associations were estimated by race/ethnicity using Cox proportional hazards regression. Adjusted attributable fractions (AAF) and cumulative absolute risk of bladder cancer were estimated across groups.

Results:

Over an average 19.7 years of follow-up 1,890 incident bladder cancer cases were diagnosed. Time-varying T2D was associated with bladder cancer in the multiethnic sample (HR = 1.17; 95% confidence interval, 1.05–1.30); however, the HR did not differ by race/ethnicity (P = 0.85). The AAF was 4.2% in the multiethnic sample and largest among Native Hawaiians (9.8%). Absolute risk of bladder cancer among European Americans without T2D was higher than all other groups with T2D.

Conclusion:

T2D is significantly associated with bladder cancer risk in a multiethnic sample.

Significance:

Those with T2D have higher incidence of bladder cancer, regardless of racial/ethnic group. Reducing T2D prevalence could substantially lower bladder cancer incidence among Native Hawaiians due to T2D being more common in this group. High absolute risk of bladder cancer among European Americans, regardless of T2D status, indicates that elevated bladder cancer risk in this group may be due to factors other than T2D. Future studies must explore reasons for this difference in incidence.
Ultra High-plex Spatial Proteogenomic Investigation of Giant Cell Glioblastoma Multiforme Immune Infiltrates Reveals Distinct Protein and RNA Expression Profiles
Authors: Bonnett Shilah A. , Rosenbloom Alyssa B. , Ong Giang T. , Conner Mark , Rininger Aric B.E. , Newhouse Daniel , New Felicia , Phan Chi Q. , Ilcisin Saskia , Sato Hiromi , Lyssand John S. , Geiss Gary , Beechem Joseph M.
Published: April 2023

A deeper understanding of complex biological processes, including tumor development and immune response, requires ultra high-plex, spatial interrogation of multiple “omes”. Here we present the development and implementation of a novel spatial proteogenomic (SPG) assay on the GeoMx Digital Spatial Profiler platform with next-generation sequencing readout that enables ultra high-plex digital quantitation of proteins (>100-plex) and RNA (whole transcriptome, >18,000-plex) from a single formalin-fixed paraffin-embedded (FFPE) sample. This study highlighted the high concordance, R > 0.85 and <15% change in sensitivity between the SPG assay and the single-analyte assays on various cell lines and tissues from human and mouse. Furthermore, we demonstrate that the SPG assay was reproducible across multiple users. When used in conjunction with advanced cellular neighborhood segmentation, distinct immune or tumor RNA and protein targets were spatially resolved within individual cell subpopulations in human colorectal cancer and non–small cell lung cancer. We used the SPG assay to interrogate 23 different glioblastoma multiforme (GBM) samples across four pathologies. The study revealed distinct clustering of both RNA and protein based on pathology and anatomic location. The in-depth investigation of giant cell glioblastoma multiforme (gcGBM) revealed distinct protein and RNA expression profiles compared with that of the more common GBM. More importantly, the use of spatial proteogenomics allowed simultaneous interrogation of critical protein posttranslational modifications alongside whole transcriptomic profiles within the same distinct cellular neighborhoods.

Significance:

We describe ultra high-plex spatial proteogenomics; profiling whole transcriptome and high-plex proteomics on a single FFPE tissue section with spatial resolution. Investigation of gcGBM versus GBM revealed distinct protein and RNA expression profiles.
Cadernos aplicados de turismo: estudos de demanda turística - Volume 2
Authors:   Universidade de São Paulo. Escola de Comunicações e Artes, Braga Debora Cordeiro , Guerra Gleice Regina ,   Universidade de São Paulo. Escola de Artes, Ciências e Humanidades, Rinaldi Thais Spiezzi ,   Strategia Consultoria Turística
Published: April 2023

A dificuldade de destinos turísticos para desenvolver projetos de turismo é recorrente, em função da pouca disponibilidade e troca de informação de qualidade entre os diferentes atores que interagem com o setor. Dessa forma, definiu-se que este número da Coleção Cadernos Aplicados de Turismo deveria tratar da demanda turística, oferecendo subsídios para que o grupo de governança local, municipal ou regional, possa implementar um processo de coleta, análise e apresentação de dados sobre visitantes. O objetivo deste material é apresentar características, métodos e modelos de investigação de demanda turística para que gestores. Para isso, o texto encontra-se dividido em cinco capítulos que buscam responder às seguintes perguntas: O que é demanda turística? Como planejar uma pesquisa sobre ela? Como coletar dados da demanda turística? Como analisar os dados? Como apresentar os dados coletados e analisados? Os tópicos aqui discutidos procuram formar a base sobre a qual será construído ou aprofundado o conhecimento a respeito da demanda turística do destino turístico.
Níveis de autocompaixão e gratidão em adultos com Transtorno por Uso de Substâncias
Authors: Souza Karine Ranzi Valentim de , Caobelli Anna Clara Sarmento Leite , Xavier Carlos Eduardo Loureiro , Camelo Karine Santos , Argimon Irani Iracema de Lima
Published: April 2023

Objetivo: identificar os níveis de autocompaixão e gratidão emadultos diagnosticados com Transtorno por Uso de Substâncias(TUS), correlacionando-os entre si e com sintomas de ansiedade,depressão e estresse. Método: modelo descritivo, quantitativoe transversal com 65 adultos. Os instrumentos utilizados foramum questionário sociodemográfico e de saúde, o Questionáriopara Triagem do Uso de Álcool, Tabaco e Outras Substâncias(ASSIST), a Escala de Gratidão (G-20), a Self-CompassionScale (SCS) e a Escala de Depressão, Ansiedade e Estresse -versão breve (DASS-21). Resultados: a subescala da DimensãoAdaptativa da SCS apontou escore médio mais elevado emSenso de humanidade (3,1±1,1) e Mindfulness (3,1±1,1),enquanto na de Dimensão Não Adaptativa se destacou a Sobreidentificação (3,6±1,1). A pontuação total da G-20 teve médiade 117,4 (dp = 19,3) pontos. Correlações significativas foramencontradas na correlação com as subescalas de ansiedadee depressão. Conclusão: os dados indicam a presença deassociações significativas entre os níveis de autocompaixão egratidão, bem como uma relação inversa com a sintomatologia,pois quanto mais gratas e autocompassivas, menos sintomasde depressão, estresse e ansiedade foram manifestados. Destaforma, fomenta estudos relacionados com intervenções emPsicologia Positiva e seus impactos na prevenção de recaídasem pacientes com TUS.
Há correlação entre classe social e a prática de atividade física?
Authors: Martinez Anna Paula , Martinez José Eduardo , Lanza Leni Boghossian
Published: April 2023

O exercício físico é recomendado para promover a saúde e melhorar a qualidade de vida. As condições para a realização de atividade física devem incluir local, roupas, supervisão e elaboração de antemão. O objetivo desta pesquisa verificar se existe influência da renda familiar na freqüência e na forma de se praticar exercícios físicos. Utilizou-se um questionário especialmente elaborado para os dados sociodemográficos, freqüência, tipo e condições da prática de exercícios. Setenta pacientes, divididos em dois grupos: assistidos por instituições públicas de saúde (A) e assistidos por organizações privadas (B). Em ambos os grupos se observou uma maioria de mulheres (A - 66%; B - 60%) e casados. Em relação ao status sócio-econômico, os membros do grupo A têm maior renda e escolaridade. Os resultados mostram maior freqüência de atividade física entre os conveniados. Ambos os grupos têm a maioria dos componentes que não praticam exercícios. Entre aqueles que praticam exercício regularmente, a maior parte o faz de 1-3 vezes por semana, com duração entre 30-50 minutos. A modalidade principal é caminhar sem supervisão ou preparação como aquecimento ou alongamento. Os níveis econômicos e educacionais não influenciam a freqüência, tipo e condições da prática de exercícios.
Fisioterapia aquática no paciente sobrevivente da Poliomielite traqueostomizado com suporte ventilatório: relato de caso
Authors: Braga Douglas Martins , Cavalheiro Daniela Potas , Ogura Adriane Fukui , Guimarães Tatiana Camargo , Farcetta Junior Fernando , Ingham Sheila Jean McNeill
Published: April 2023

Muitos pacientes sobreviventes da poliomielite apresentam importante comprometimento da função respiratória. A fisioterapia aquática é indicada para esta população, porém, a presença da traqueostomia leva a uma maior dificuldade de tratamento no meio líquido pela dificuldade da manipulação. O objetivo deste trabalho é verificar os benefícios que uma paciente traqueostomizada, com suporte ventilatório não invasivo, pode ter com a abordagem da fisioterapia aquática. A paciente sofreu intervenção de vinte sessões de fisioterapia aquática. Para avaliação foram usadas as Escalas de Fadiga, Dor e Qualidade de vida e analisados os parâmetros: Saturação de Oxigênio (SatO2), Freqüência Cardíaca (FC)e Freqüência Respiratória (FR). Foi constatada melhora na pontuação de todas as escalas de fadiga utilizadas: inicial 55 e final 28, demonstrando ao final do estudo ausência de fadiga Fator esse também verificado na qualidade de vida principalmente na dimensão de vitalidade inicial 29,16 e final 50. A FC, a (excluir) FR e a SatO2 não sofreram alterações significativas, observando dessa maneira a segurança durante o atendimento. No término do tratamento, o quadro álgico cessou nos principais grupos articulares. Os resultados demonstraram que o meio líquido foi favorável para o tratamento dessa paciente, garantindo a segurança, diminuindo a fadiga e a dor, melhorando assim a qualidade de vida.
XXVII Congresso Brasileiro de Medicina Física e Reabilitação
Authors: Fisiátrica Acta
Published: April 2023

O objetivo da Associação Brasileira de Medicina Física e Reabilitação (ABMFR) é o de sempre promover eventos com responsabilidade.  Na organização do XXVII Congresso Brasileiro de Medicina Física e Reabilitação e preocupados com a possibilidade de sofrermos uma baixa no nosso público de médicos, profissionais da saúde e seu corpo de palestrantes internacionais e nacionais, entendemos que deveríamos nos organizar em um novo formato, agora virtual. Nosso evento aconteceu de 7 a 10 abril de 2021, através da plataforma virtual. A Comissão Cientifica preparou a melhor programação, contemplando os diversos aspectos da reabilitação, envolvendo profissionais nacionais e internacionais renomados e atuantes na área de Reabilitação, composta por Médicos Fisiatras e de outras especialidades afins, Fisioterapeutas, Terapeutas Ocupacionais, Psicólogos, Assistentes Sociais.
Eduardo de Melo Carvalho Rocha
PresidenteAssociação Brasileira de Medicina Física e Reabilitação
Reabilitação e atenção à pessoa com deficiência na atenção primária à saúde no Brasil: dados do 2º e 3º ciclos do Programa de Avaliação da Qualidade a Atenção Básica
Authors: Carvalho Bruna Lilian Severino , Nascimento Ana Luiza Maia , Silva Silvia Lanziotti Azevedo , Brandão Celso Brendo Furtado , Silva Laíze Gabriele de Castro , Moreira Lorrane Brunelle , Brito Geraldo Eduardo Guedes de
Published: April 2023

Objetivo: Descrever e comparar ações de atenção e reabilitação na Atenção Primaria à Saúde (APS) direcionados à Pessoa com Deficiência (PCD) no Brasil. Métodos: Dados do Programa de Avaliação da Qualidade na Atenção Básica (PMAQ-AB). Foi realizada uma análise com base no Módulo IV do 2º (2015) e do 3º (2018) Ciclo do PMAQ-AB. Foram realizadas comparações da avaliação positiva (“sim”) dos cuidados prestados à PCD na APS, através do cálculo a Razão de Prevalência (RP), admitindo o 2º Ciclo como categoria de referência e considerando dados nacionais e das cinco regiões geográficas. Resultados: A prevalência de repostas afirmativas para atenção à PCD aumentou no 3º ciclo no cenário nacional em relação ao apoio em ações direcionadas à PCD, avaliação e adaptação no domicílio e promoção da inserção da PCD em atividades de esporte e lazer. A prevalência de ações de reabilitação na APS no Brasil também aumentou. O cenário das mudanças no cuidado à PCD foi diferente entre as regiões brasileiras. A região Nordeste foi a que mais aumentou o percentual de ações de atenção à PCD, seguindo o padrão nacional, e ainda incluindo aumento no encaminhamento para uso de próteses/órteses e dispositivos de auxílio. Conclusão: Para a maioria das atividades avaliadas, houve aumento da prevalência de sua realização entre as avaliações do 2º e 3º ciclos do PMAQ-AB, entretanto há necessidade ainda de ampliar a oferta e o serviço de algumas atividades na maioria das regiões do país, favorecendo o cuidado integral à PCD.
Duas evidências de validade da ESQUADA e níveis de qualidade da dieta dos brasileiros
Authors: Santos Thanise Sabrina Souza , Araújo Pedro Henrique de Moura , Andrade Dalton Francisco de , Louzada Maria Laura da Costa , Assis Maria Alice Altenburg de , Slater Betzabeth
Published: April 2023

No artigo “ Duas evidências de validade da ESQUADA e níveis de qualidade da dieta dos brasileiros ”, DOI https://doi.org/10.11606/s1518-8787.2021055002397, publicado na Revista de Saúde Pública.2021;55:39, na página 10, a RSP corrige um trecho do último parágrafo da seção resultados.
 

Onde se lê:
 

θ(250,50) = 59,09 × θ(0,1) + 250.12
 

Leia-se:
 

θ(250,50) = 50 × θ(0,1) + 250.12
Decreased Estimated Glomerular Filtration Rate and Proteinuria and Long-Term Outcomes After Ischemic Stroke: A Longitudinal Observational Cohort Study
Authors: Ueki Kana , Matsuo Ryu , Kuwashiro Takahiro , Irie Fumi , Wakisaka Yoshinobu , Ago Tetsuro , Kamouchi Masahiro , Kitazono Takanari , Ishitsuka Takao , Ibayashi Setsuro , Kusuda Kenji , Fujii Kenichiro , Nagao Tetsuhiko , Okada Yasushi , Yasaka Masahiro , Ooboshi Hiroaki , Irie Katsumi , Omae Tsuyoshi , Toyoda Kazunori , Nakane Hiroshi , Sugimori Hiroshi , Arakawa Shuji , Fukuda Kenji , Kitayama Jiro , Fujimoto Shigeru , Arihiro Shoji , Kuroda Junya , Fukushima Yoshihisa , Nakamura Kuniyuki , Kiyohara Takuya , Hata Jun , Kumai Yasuhiro
Published: April 2023

Background:

It remains unclear how chronic kidney disease and its underlying pathological conditions, kidney dysfunction, and kidney damage, are associated with cardiovascular outcomes. This study aimed to determine whether kidney dysfunction (ie, decreased estimated glomerular filtration rate), kidney damage (ie, proteinuria), or both are associated with the long-term outcomes after ischemic stroke.

Methods:

A total of 12 576 patients (mean age, 73.0±12.6 years; 41.3% women) with ischemic stroke who were registered in a hospital-based multicenter registry, Fukuoka Stroke Registry, between June 2007 and September 2019, were prospectively followed up after stroke onset. Kidney function was assessed by estimated glomerular filtration rate and categorized into G1: ≥60 mL/(min·1.73 m
2
), G2: 45–59 mL/(min·1.73 m
2
), and G3: <45 mL/(min·1.73 m
2
). Kidney damage was evaluated by proteinuria using a urine dipstick test and classified into P1: −, P2: ±/1+, and P3: ≥2+. Hazard ratios and 95% CI for events of interest were estimated by a Cox proportional hazards model. Long-term outcomes included recurrence of stroke and all-cause death.

Results:

During the median follow-up of 4.3 years (interquartile range, 2.1–7.3 years), 2481 patients had recurrent stroke (48.0/1000 patient-years) and 4032 patients died (67.3/1000 patient-years). Chronic kidney disease was independently associated with increased risks of stroke recurrence and all-cause death even after adjustment for multiple confounding factors, including traditional cardiovascular risk factors. Both estimated glomerular filtration rate and proteinuria were independently associated with increased risks of stroke recurrence (multivariable-adjusted hazard ratio [95% CI], G3: 1.22 [1.09–1.37] versus G1, P3: 1.25 [1.07–1.46] versus P1) and death (G3: 1.45 [1.33–1.57] versus G1, P3: 1.62 [1.45–1.81] versus P1). In subgroup analyses, effect modifications were found in the association of proteinuria with death by age and stroke subtype.

Conclusions:

Kidney dysfunction and kidney damage were independently, but differently, associated with increased risks of recurrent stroke and all-cause death.
Augmented Reality in Physics Education: Students with Intellectual Disabilities Inquire the Structure of Matter
Authors: Iatraki Georgia , Mikropoulos Tassos A.
Published: April 2023

Immersive technologies support educational activities and provide motivating contexts which are increasingly implemented in special education settings. Augmented Reality (AR) seems to improve the level of engagement in teaching and learning processes for all students, including students with Intellectual Disabilities (ID). However, there is a lack of research that investigates AR learning environments where students with ID can be involved in inquiry-based activities and acquire academic content linked to real situations. The purpose of this study was to implement a single-subject design and evaluate the effects of an AR system on students’ performance on the microscopic level of the structure of matter and especially the phase-states of water. A functional relationship was found between students’ correct responses during probe sessions and the AR inquiry-based intervention. In addition, a social validity assessment indicated that the AR glasses helped students with ID to acquire physics concepts, as well as inquiry skills in a vivid experience. The students also reported satisfaction from using the AR glasses. Suggestions for future research include the design of AR-based interventions for other science concepts for students with ID as well as other special educational needs.
Further Applications of Social Cognition to Göbekli Tepe
Authors: Henley Tracy B. , Reysen Stephen
Published: April 2023

Göbekli Tepe is an archaeological site that has challenged much prior thought on human history with respect to our Neolithic revolution from animistic, egalitarian, hunter-gatherers to settled, socially stratified, and religious peoples. In the present paper we review the structures and possible purposes of Göbekli Tepe, summarize past considerations of the connection between psychological concepts and matters found thereat, and then introduce social identity theory as an apt theoretical perspective from which to best understand the peoples who constructed and utilized the site. Throughout we show that social-cognitive processes and concepts have merit in interpreting the advent and utility of Göbekli Tepe, suggesting then a greater use for psychology within the framework of cognitive archaeology.
The Battle of Ideas under LOSC Dispute Settlement Procedures
Authors: Song Ke
Published: April 2023

Dispute settlement procedures under the United Nations Convention on the Law of the Sea (LOSC) can be a great laboratory for observing judicial processes of exploring and testing the acceptability of multiple solutions to issues of interpretation through a battle of ideas among LOSC adjudicators. The analysis observes that LOSC tribunals tend towards two jurisprudential patterns when battling their ideas: (1) the International Tribunal for the Law of the Sea (ITLOS) takes an implicit approach of deviating from previous case law of other LOSC tribunals; and (2) Annex VII arbitral tribunals have been quite straightforward when facing a diverging interpretative discourse. This article explains the institutional dynamics underpinning these two jurisprudential patterns. Calibrating judicial reasoning of the ITLOS is proposed, which would hopefully stimulate a vibrant battle of ideas facilitating coherent development of international law.
The International Laws of War: Linguistic Analysis from the Perspectives of Register, Corpus and Grammatical Patterning
Authors: Lukin Annabelle , Marrugo Alexandra García
Published: April 2023

All texts, including all legal texts, are constructed in language. All legal constructs and discriminations are an effect of language. As such, linguistics and text analysis should be considered a necessary adjunct to legal studies and, in particular, to critical legal studies. While the disciplines of linguistics and law are increasingly interacting, there is a paucity of linguistic analysis in the field of the international laws of war. This paper seeks to open doors to collaboration, by viewing the texts of the international laws of war from three linguistic perspectives: as a ‘register’, as a ‘corpus’, and in terms of their lexicogrammatical patterning. In terms of register, the international laws of war herald a new form of textual practice, the function and effects of which are subject to debate. As a corpus, some dominant lexical habits of these texts are explored and interpreted for their ideological implications and reactances. Finally, an examination of covert lexicogrammatical meanings in this register, via a small extract from Article 8 of the Rome Statute, illuminates the contradictory meanings that these texts navigate. These three perspectives offer a preliminary glimpse into the value of linguistic analysis for critical perspectives on the international laws of war.
Review of Harpactea ground-dwelling spiders (Araneae: Dysderidae) of Portugal
Authors: ŘEZÁČ MILAN , CARDOSO PEDRO , ŘEZÁČOVÁ VERONIKA
Published: April 2023

We revise the Portuguese spiders of the genus Harpactea Bristowe, 1939 (Araneae: Dysderidae). The following seven new species are described: H. adicensis sp. nov., H. crespoi sp. nov., H. dolanskyi sp. nov., H. henriquesi sp. nov., H. korenkoi sp. nov., H. krejcii sp. nov. and H. pekari sp. nov. In three species, H. algarvensis Ferrández, 1990, H. minoccii Ferrández, 1982 and H. tavirensis Wunderlich, 2020 the females are described for the first time. The Portuguese Harpactea spiders belong to two species groups, namely the hombergi group and the corticalis group (sensu Deeleman-Reinhold 1993). The majority of the Portuguese representatives of the corticalis group probably constitute a monophyletic group endemic for the Iberian peninsula, the minoccii subgroup Ferrández, 1990. The synapomorphy of this clade is the unique position of partners during copulation: the male grasps one of the femaleʼs chelicerae between his chelicerae. The malesʼ chelicerae are morphologically adapted for this behaviour. Due to this unusual position during copulation the female genitalia are more distant from the male than in other Harpactea species. Therefore, the pedipalps are more elongated . Furthermore, the males of this subgroup possess larger basal part of male copulatory organ (the tegulum), where the ejaculate is stored before copulation. We observed that the males of this subgroup invest significantly more time into single copulation than the other representatives of the corticalis group with smaller tegulum. Therefore, enlargement of the tegulum might reflect different sperm competition strategy, in which males invest more ejaculate in each copulation. In Portugal, Harpactea spiders are frequently found under woody plants that produce slowly decomposing leaf litter, usually Quercus spp., or introduced Eucalyptus sp. These spiders require slightly humid substratum.
Do the Palaearctic subgenera of Podistra Motschulsky, 1839 really occur in North America: description of P. ( Pidostria ), subgen. nov. (Coleoptera: Cantharidae)
Authors: KAZANTSEV SERGEY V.
Published: April 2023

A new subgenus, Pidostria subgen. nov., is described in Podistra Motschulsky, 1839 for a North American member of the genus, all the remaining subgenera thus become confined to the Palaearctic region. The new taxon is retained in Podistra due to the structure of its aedeagus, despite the differences in such morphological characters, as elytral vestiture, shape of ultimate palpomeres and protarsal claw dent. Pseudoabsidia Wittmer, 1969, syn. nov. is proposed as a new synonym of Podistra. Podistra (Absidia) pentheri Ganglbauer, 1922 is transferred to Pakabsidia Wittmer, 1972 as Pakabsidia pentheri (Ganglbauer, 1922), comb. nov. Podistra longicornis Wittmer, 1978 is transferred to Cantharis Linnaeus, 1758 as Cantharis longicornis (Wittmer, 1978), comb. nov. Podistra (Pseudoabsidia) sanbernardensis (Fender, 1972) and Cantharis (Cyrtomoptila) sierrae (McKey-Fender, 1950) are transferred to Podistra incertae sedis. Provided are a key to the subgenera, a list of species of Podistra and a map of their distribution worldwide.
The Austral Predator Katydid—new species of Megatympanon Piza, 1958 (Orthoptera: Tettigoniidae: Listroscelidinae: Terpandrini) from the Brazilian Atlantic Rainforest
Authors: MENDES DIEGO MATHEUS DE MELLO , SOBRAL RAFAEL , NETO ALBERTO MOREIRA DA SILVA
Published: April 2023

Megatympanon Piza, 1958 (Tettigoniidae: Listroscelidinae: Terpandrini) is presently a monotypic genus and the only Terpandrini occurring in South America. The type-species M. speculatum Piza, 1958 is recorded in the Atlantic Forest biome in southeastern Brazil. In this work, we describe an additional species, Megatympanon austroraptorum sp. nov., the second species of the genus, occurring in the Southern Atlantic Forest biome. The new species is described based only on a single male; the female of the new species is unknown. A distribution map of the genus is provided as well as comments on the natural history of the new species.
Risks and Fallacies of Expanding New Roles to the Military: The Case of the Spanish Emergency Military Unit; A Research Note
Authors: Bueno Alberto , Martínez Rafael
Published: April 2023

This article responds to the analysis about the Spanish Emergency Military Unit in the research note by Pérez et al. in Armed Forces & Society, which emphasizes the efficiency of the Spanish Emergency Military Unit and how it has enhanced the image of the Spanish Armed Forces. We believe that a more critical understanding of the development of this military unit is necessary, as its deployment pitfalls and the literature on civil–military relations were neglected. Consequently, four policy traps are identified: response to civilian emergencies has become a central task of the armed forces rather than an auxiliary role; behind the pragmatism of its employment, there is potential for a worsening of civil–military relations, as highlighted by the scholarly literature; there are serious inefficiencies in its organizational design, related to human and financial resources; and image improvement is an illusion, strongly conditioned by political cleavages, with potential long-term counterproductive results.
Evaluation of Open-Graded Aggregates Stabilized with a Multi-Axial Geogrid Using a Large-Scale Triaxial Test Set-Up
Authors: Wang Han , Kang Mingu , Qamhia Issam I. A. , Tutumluer Erol , Wayne Mark H. , Shoup Heather
Published: April 2023

Geogrids are commonly used in paved and unpaved roadways to stabilize base and subbase layers by laterally restraining movements of unbound aggregates under applied wheel loading, often referred to as interlocking. The geogrid-aggregate interlock is a function of the match between the geogrid aperture size and geometry and the grain size and shape characteristics of the stabilized aggregates. Open-graded coarse aggregates (OGA) are commonly used as an alternative to dense-graded materials in permeable base/subbase applications as well as in railway ballast to facilitate drainage. This paper describes an experimental study recently conducted to investigate the repeated load-deformation behavior of a geogrid-stabilized OGA material in large-scale triaxial testing. Two multi-axial geogrids with the same aperture patterns but different aperture sizes were tested. The aperture patterns include different sizes of hexagonal, trapezoidal, and triangular openings. The multi-axial geogrid with the larger apertures better matched the OGA material properties to provide a reduction in permanent deformation in the test specimen. The improved interlocking and the related local stiffness enhancement were successfully quantified using embedded shear wave transducers termed bender elements. To stabilize aggregates with relatively uniform grain sizes, for example, AASHTO No. 57 stone studied here and railroad ballast, the ratio between the aperture size and a representative particle size (i.e., D90) served as a good indicator of the effectiveness of the geogrid. The findings of this experimental study therefore provided valuable information on the governing properties and mechanisms that play a role in geogrid-aggregate interaction with multi-axial geogrids.
Dynamics-based deep learning and fractional-order fixed-time sliding mode control for space robot impedance system
Authors: Zhao Tongyu , Sun Guanghui , Zhu Weihong
Published: April 2023

To complete complex tasks with space robots in the impedance environment, sliding mode control (SMC) has been proposed and plays an important role in the past decades. Learning-based control has also met with great success in robotics and has been closely followed in the control of space robots. However, as an interdisciplinary, only a few studies have combined deep learning and traditional controller in the space robot directly. This paper proposes a novel fractional-order fixed-time SMC for impedance control of space robots, taking advantage of a model-based deep learning approach to obtain the dynamics of space robots. The learning results are used to make predictions for the data-based robot dynamics. The fractional-order fixed-time SMC controller is added to that data-based model, and it ensures the finite closed-loop convergence time. Small-dataset training is more reasonable in the situation of space robots, which reduces training time and sampling size. Compared to traditional methods, combining deep learning and fractional-order fixed-time SMC provides better tracking performance and improves closed-loop robustness. It accomplishes the control target in the impedance model using the estimated data-driven parameters. Theoretical analysis proves the closed-loop behavior, and simulation results verify its effectiveness.