bluuebunny/crossref_metadata_2025 huggingface dataset:
Leptin and its receptor gene polymorphism as a target for pharmacotherapy in T2DM and COPD
Authors: Sorokina Yu. A. , Zanozina O. V. , Makarova E. V. , Salcev S. G. , Varvarina G. N. , Lovtsova L. V.
Published: May 2021

Combined pathology is a real problem for rational pharmacotherapy due to multiple organ damage. The need to affect simultaneously several pathogenesis processes leads to polypharmacy that can appear to be less effective, toxic and unacceptable in some time. For comorbid patients with long - term ongoing type 2 diabetes mellitus (T2DM), the problem of drug interactions is as relevant as the selection of optimal hypoglycemic therapy. This review aims to identify opportunities to optimize drug therapy in comorbid pathology to increase the effectiveness of pharmacotherapy, improve the prognosis and outcomes of concomitant diseases, and slow the progression of one or a combination of diseases. One of the ways to individualize pharmacotherapy is to identify polymorphic genes that can account not only to the predisposition to the disease, but also to the formation of a pharmacological response, thus determining the effectiveness of drug therapy. A peptide hormone leptin along with its receptors in various tissues could be the milestone of unifying pathology that contributes both to the development of diseases - chronic obstructive pulmonary disease (COPD) and T2DM. This modality potentially forms the pharmacological response to prescribed drug therapy of such. Gene polymorphism determines the development of pathologies such as leptin and insulin resistance. These deteriorations are in turn likely to be the targets of many oral antidiabetic drugs. The review suggests potential associations and directions for research in the field of pharmacogenetics of drugs used for the treatment of comorbid patients. The duly identified mutations involved in the general pathogenesis of type 2 diabetes and COPD will account to the approach toward tailored medicine and contribute to proper control of both diseases.
Comparison of two culture methods for the enumeration of Legionella pneumophila from potable water samples
Authors: Boczek Laura A. , Tang Min , Formal Casey , Lytle Darren , Ryu Hodon
Published: May 2021

Legionella infections have steadily increased in the United States over the last 20 years, and most of these infections have been attributed to contaminated water. The gold standard for confirmation of Legionella presence in water is culturing with Buffered Charcoal Yeast Extract (BCYE) agar. Following many modifications, this method is still time-consuming, expensive, and can take longer than 10 days for full confirmation. The Legiolert is a newer and simpler culture product that is claimed to be able to quantify Legionella pneumophila in 7 days with high sensitivity and specificity and does not need further confirmation for the presence of L. pneumophila. This study compared the culturability of L. pneumophila occurring in a simulated home plumbing system using both Legiolert and BCYE agar methods. Out of 185 water samples, Legiolert and BCYE method detected L. pneumophila in 83 and 85% of the samples, respectively. The two methods were determined to be statistically equivalent for culturability of L. pneumophila, though the detected levels by Legiolert were slightly higher than the BCYE method. The molecular confirmation of positive (n = 254) and negative wells (n = 82) with Legiolert also showed a high specificity of 96.5% (i.e., 3.5% false positives (9/254) and 0% false negatives (0/82)).
Exploring the important determinants of access to safe drinking water and improved sanitation in Punjab, Pakistan
Authors: Adil Shahid , Nadeem Muhammad , Malik Irfan
Published: May 2021

Access to safe drinking water and improved sanitation is a fundamental human right and basic ingredient of public health. However, one of the major problems faced by developing countries in the twenty-first century is the lack of access to these facilities. Punjab, the most populous province of Pakistan with more than 50% of the country's population, is no exception. Keeping in view its importance, the current study is an effort to investigate important determinants of access to safe drinking water and improved sanitation in Punjab to ensure the provision of these services to the masses. Multiple Indicator Cluster Survey Household data from 2017 to 2018 has been used for analysis. The results of a logistic regression model revealed that household media exposure, education level of household head, household wealth status, and ethnic background of the household head are some of the important determinants of household access to safe drinking water. For household access to improved sanitation, along with these factors, the role of social norms and place of residence are also important. Particularly, the role of social norms is very profound. Findings from the study suggest that efforts should be made to provide readily available media access, household education level needs to be enhanced, policies should be made to raise the living standard of the poorest households, and the social norm for the use of improved sanitation needs to be promoted.
Percepción de la enfermera en el arte de cuidar
Authors: Reina Rosa , Cardenas María Hilda
Published: May 2021

Introducción: El cuidado de enfermería como arte exige destrezas particulares, conocimiento y capacidades para establecer vínculos significativos, orientar el curso apropiado de la acción cuidadora, dando sentido a lo cotidiano, para satisfacción del paciente. Objetivo: Comprender la percepción de la enfermera al arte de cuidar; un aporte epistemológico que contribuya a fortalecer la práctica profesional y el componente del conocimiento estético que envuelve el objeto material de Enfermería, el arte de cuidar. Materiales y Métodos: La técnica de recolección de la información por entrevista en profundidad y la observación interpretativa, a enfermeras de los servicios de Medicina, Cirugía y Gineco-obstetricia, que aceptaron participar en el estudio, guardando la confidencialidad convenida en el consentimiento informado. El aporte teórico-explicativo fue determinado por dos (2) categorías: El arte de cuidar es conocimiento y la forma de hacer las cosas y El cuidado individual basado en las necesidades. Resultados: Como consideraciones de cierre se tiene que el estudio del arte de cuidar permitió comprender el significado que le asignan al arte de cuidar en su desempeño cotidiano un grupo de profesionales de enfermería y de pacientes, además de comprender el sentido global de la práctica del cuidado y su complejidad. Todo lo cual nos permite asumir y sentirnos protagonistas como agentes de cambio de los modos de cuidar de nuestra profesión. Conclusión: La investigación del cuidado de enfermería se enriquece con la producción del conocimiento, que la enfermera puede asumir y emplear para fortalecer el papel de cuidadora como acompañante en los procesos de desarrollo y crecimiento de la civilidad humana.
Purilinguismo para o ensino fundamental brasileiro
Authors: Barbosa de Oliveira Melo Priscilla
Published: May 2021

Refletir sobre o uso da linguagem e sobre a aula de língua estrangeira e seu relevante papel sociocultural nos faz pensar em possibilidades de ampliar o repertório linguístico e cultural do aluno. Consequentemente, chegamos ao estudo do plurilinguismo, a saber, a experiência pessoal e cultural, do indivíduo em diferentes línguas. Para tanto, pretende-se explorar os documentos oficiais que estão em uso no Brasil e trazer também documentos internacionais que estão – de certa forma e até certo grau – presentes nos estudos e na produção acadêmica do Brasil, e assim constatar a presença do plurilinguismo pedagógica e legislativamente no país. Para a elaboração deste artigo, far-se-á uma pesquisa de levantamento bibliográfico dos documentos oficiais para o ensino de línguas sobre o plurilinguismo voltado para a educação básica – mais especificamente o 3º e o 4º ciclo do ensino fundamental II – no que se diz respeito ao ensino de línguas. Este artigo buscou, no cenário educacional, o lugar do plurilinguismo e, deste modo, evidenciou sua consolidada presença e importância na atualidade para a formação do aluno, do professor, como também para sua prática em sala de aula.
Clinical and Nutritional Implications of Kidney Disease and COVID-19
Authors: Vasquez Hazel Esther Anderson , Albornoz Cristhy , D´Marco Luis , Ariza Daniela , Morillo Valery , Carrasquero Rubén , Nava Manuel , Guerra-Torres Xavier E. , Bermúdez Valmore
Published: May 2021

By the end of 2019 emerged a cluster of pneumonia that was caused by a novel SARSCoV-
2 virus. The disease, subsequently named COVID-19, has a wide range of signs and symptoms,
including fever, respiratory and gastrointestinal manifestations, and kidney disease that can
evolve to a nutritional imbalance through direct and indirect mechanisms. Moreover, the prognosis
of COVID-19 could worsen in high-risk populations like kidney disease patients, given their
depressed immunity and impaired nutritional state. Therefore, previous reports suggest prioritizing
a nutritional approach in these patients, adjusting for individual dietary needs. Thus, we aim
to explore the current knowledge about the clinical and nutritional implications of patients with
COVID-19 who develop acute or chronic kidney disease, highlighting proposed dietary recommendations
in this group of patients.
Natural Products for Fungal Diseases Management and Prevention
Authors: Akhtar Nahid , Ayoubi Rabia , Kour Vinaypreet , Gautam Umesh , Amin-ul Mannan Mohammad
Published: May 2021

Fungal diseases cause more deaths as compared to combined deaths due to malaria and
tuberculosis. There are around 3.8 million fungal species, but only about 300 of them are pathogenic
to humans. Invasive fungal diseases are majorly caused by Aspergillus, Candida, Cryptococcus,
Histoplasma, Mucorales, and Pneumocystis. It has been estimated that around 1.5 million people
die because of these infections across the globe. The emergence of resistance against the major
classes of antifungal drugs poses a serious threat to public health. Moreover, the commonly used
antifungal drugs are loaded with side-effects. Some of them are nephrotoxic, hepatotoxic, cause cardiomyopathy,
and in acute cases, cytotoxicity. Hence, it is important to seek novel molecules that
can be safe and effective antifungal drugs. Naturally occurring molecules in plants and various microorganisms
can be a safe and effective alternative to the existing antifungal drugs. In this review,
the role of various phytochemicals, such as alkaloids, flavonoids, saponins, and phenols, as potential
antifungal agents has been discussed. Similarly, naturally occurring molecules in other microorganisms
like algae, bacteria, and various other fungi have been summarized. The information discussed
in this review can be useful in the identification of novel antifungals.
Narco-Culture as a distortion of gender stereotypes: An aggravating factor in the situation of violence and conflict in society
Authors:   Escuela de Formación de Infantería de Marina, Miranda Yanes Massiel , Valdes Salas Shanny ,   Escuela de Formación de Infantería de Marina
Published: May 2021

Today, Narco-Culture has transformed many aspects in some society. One of the aspects still to be explored is linked to studies of gender stereotypes, because very little research has been done on this subject. For this reason, the main objective of this article is to explore how drug trafficking has distorted gender stereotypes, linking this viewpoint as an aggravating factor in situations of conflict and violence in society, taking Colombian society as a reference and yet it could be applied to other countries and contexts. Thus, the premise of the article is that the Narco-Culture has changed the role of men and women in society. The most significant findings show that the gender perspective provides a holistic view of the phenomenon of violence in society and can therefore help authorities to design effective public policies that break its cycle, Understanding also that society and culture have a great direct and indirect responsibility in the perpetuation of drug trafficking and all manifestations of violence.
Sostenibilidad económica empresarial del sector agroindustrial en Venezuela. Un aporte necesario para el desarrollo del país
Authors: Pérez Prieto María Elena , Jiménez Paternina Lucimio , Piña Paola Lesneigly , Acosta Campos Ivonne C.
Published: May 2021

El objetivo de la investigación fue analizar la sostenibilidad económica del sector agroindustrial del estado Trujillo-Venezuela. Epistemológicamente, el estudio se encuadra en el enfoque empírico inductivo, con un diseño de campo. Se encuestaron 22 empresas, y para el procesamiento de los datos se consideró pertinente la estadística descriptiva. Los resultados indican bajo desempeño en los indicadores: producción y comercialización de alimentos frescos y de alta calidad, desempeño económico y financiero, manejo de riesgo en los precios, acceso a incentivos estatales, impacto económico indirecto, capacidad asociativa, identificación y conocimiento de los grupos de interés, resultando afectada la sostenibilidad económica de estas empresas.
Regulación jurídica ambiental de las ciudades en Colombia
Authors: Madera Arias Nadin , Guerra David Aníbal , Hernández Camilo
Published: May 2021

Regulación jurídica ambiental de las ciudades en Colombia es el resultado de una investigación concluida sobre la protección del medio ambiente mediante las normas jurídicas del Estado colombiano, de modo que, este segmento de la investigación buscó identificar las disposiciones jurídicas del país relacionadas con el medio ambiente, guardando especial relación con el ente territorial referente al municipio y cómo este, a través de la Alcaldía, puede lograr la visión de ciudad sostenible. En ese sentido, se examinaron normas del orden internacional, vinculantes para Colombia, y normas del orden nacional con especial énfasis de rango territorial para entender el marco integral de protección al medio ambiente; ello resulta relevante porque permite obtener un panorama claro sobre las herramientas jurídicas que se cuentan y, además, como insumo para el estudio de la eficacia y aplicación de los mecanismos para la protección del medio ambiente en las investigaciones subsiguientes.
El ecoturismo en Córdoba una alternativa de desarrollo sostenible para el turista internacional
Authors: Pérez Vásquez Manuel Antonio , Prieto Baldovino Francia Helena
Published: May 2021

El ecoturismo, se ha convertido en una actividad que propone la conjunción de todos los atractivos turísticos y de las potencialidades naturales de Colombia. El presente artículo tiene como propósito central estudiar cómo elecoturismo en el departamento de Córdoba es una alternativa de desarrollo sostenible para el turista internacional. La investigación es de tipo descriptivo: se identifican tanto las potencialidades como las dificultades para el desarrollo de las actividades de ecoturismo en esta zona. Los hallazgos indican que ante la débil competitividad de las empresas turísticas en el país es necesario aprovechar las potencialidades turísticas, naturales y socioculturales de las regiones mediante la descripción de sus características por zonas; con la finalidad de determinar los lineamientos especiales de intervención para proyectos turísticos integrales en dichos territorios. También, los resultados resaltan que las actividades turísticas requieren de la cooperación comunitaria, del fortalecimiento institucional y la resiliencia sistémica para sugestión. Se concluye que en el departamento de Córdoba es necesaria la inversión en equipamiento turístico, la diversificación de la oferta turística y formación del recurso humano. Asimismo, es esencial el uso de las nuevas tecnologías de la información y las comunicaciones para el desarrollo de una comercialización turística eficiente, en función de dar a conocer los servicios de este sector y de promover una cultura ciudadana, educación ambiental y sensibilización de la población local hacia el ecoturismo.
Fatigue behaviour of material-adapted fibre-reinforced polymer/metal joints
Authors: Gerstenberger Colin , Osiecki Tomasz , Kroll Lothar
Published: May 2021

By regarding the needs and requirements in modern multi-material joining, the Flow Drill Joining Concept (FDJ) was developed at the Chemnitz University of Technology. The technology allows an efficient and material-adapted joining of thin metal sheets with continuous fibre-reinforced thermoplastics, as required in modern lightweight engineering. For a better understanding of their fatigue behaviour, single-lap FDJ joints were examined in quasi-static and dynamic tests regarding shear loads, cross tension and superimposed shear/cross tension loads. By way of example, joints between micro-alloyed steel with high yield strength for cold forming and a continuous glass/carbon fibre-reinforced polyamide 6 were investigated. The fatigue curves show inclinations between k = 8.01 (shear loads) and k = 5.17 (cross tension loads), depending on the applied load angle. The results of the fatigue testings represent a basis for the enhancement of a failure criterion for FRP/metal joints in highly stressed multi-material designs.
Using Machine Learning to Compare Provaccine and Antivaccine Discourse Among the Public on Social Media: Algorithm Development Study
Authors: Argyris Young Anna , Monu Kafui , Tan Pang-Ning , Aarts Colton , Jiang Fan , Wiseley Kaleigh Anne
Published: May 2021

Background

Despite numerous counteracting efforts, antivaccine content linked to delays and refusals to vaccinate has grown persistently on social media, while only a few provaccine campaigns have succeeded in engaging with or persuading the public to accept immunization. Many prior studies have associated the diversity of topics discussed by antivaccine advocates with the public’s higher engagement with such content. Nonetheless, a comprehensive comparison of discursive topics in pro- and antivaccine content in the engagement-persuasion spectrum remains unexplored.

Objective

We aimed to compare discursive topics chosen by pro- and antivaccine advocates in their attempts to influence the public to accept or reject immunization in the engagement-persuasion spectrum. Our overall objective was pursued through three specific aims as follows: (1) we classified vaccine-related tweets into provaccine, antivaccine, and neutral categories; (2) we extracted and visualized discursive topics from these tweets to explain disparities in engagement between pro- and antivaccine content; and (3) we identified how those topics frame vaccines using Entman’s four framing dimensions.

Methods

We adopted a multimethod approach to analyze discursive topics in the vaccine debate on public social media sites. Our approach combined (1) large-scale balanced data collection from a public social media site (ie, 39,962 tweets from Twitter); (2) the development of a supervised classification algorithm for categorizing tweets into provaccine, antivaccine, and neutral groups; (3) the application of an unsupervised clustering algorithm for identifying prominent topics discussed on both sides; and (4) a multistep qualitative content analysis for identifying the prominent discursive topics and how vaccines are framed in these topics. In so doing, we alleviated methodological challenges that have hindered previous analyses of pro- and antivaccine discursive topics.

Results

Our results indicated that antivaccine topics have greater intertopic distinctiveness (ie, the degree to which discursive topics are distinct from one another) than their provaccine counterparts (t122=2.30, P=.02). In addition, while antivaccine advocates use all four message frames known to make narratives persuasive and influential, provaccine advocates have neglected having a clear problem statement.

Conclusions

Based on our results, we attribute higher engagement among antivaccine advocates to the distinctiveness of the topics they discuss, and we ascribe the influence of the vaccine debate on uptake rates to the comprehensiveness of the message frames. These results show the urgency of developing clear problem statements for provaccine content to counteract the negative impact of antivaccine content on uptake rates.
Understanding Behavioral Intentions Toward COVID-19 Vaccines: Theory-Based Content Analysis of Tweets (Preprint)
Authors: Liu Siru , Liu Jialin
Published: May 2021

BACKGROUND

Acceptance rates of COVID-19 vaccines have still not reached the required threshold to achieve herd immunity. Understanding why some people are willing to be vaccinated and others are not is a critical step to develop efficient implementation strategies to promote COVID-19 vaccines.

OBJECTIVE

We conducted a theory-based content analysis based on the capability, opportunity, motivation–behavior (COM-B) model to characterize the factors influencing behavioral intentions toward COVID-19 vaccines mentioned on the Twitter platform.

METHODS

We collected tweets posted in English from November 1-22, 2020, using a combination of relevant keywords and hashtags. After excluding retweets, we randomly selected 5000 tweets for manual coding and content analysis. We performed a content analysis informed by the adapted COM-B model.

RESULTS

Of the 5000 COVID-19 vaccine–related tweets that were coded, 4796 (95.9%) were posted by unique users. A total of 97 tweets carried positive behavioral intent, while 182 tweets contained negative behavioral intent. Of these, 28 tweets were mapped to capability factors, 155 tweets were related to motivation, 23 tweets were related to opportunities, and 74 tweets did not contain any useful information about the reasons for their behavioral intentions (κ=0.73). Some tweets mentioned two or more constructs at the same time. Tweets that were mapped to capability (P<.001), motivation (P<.001), and opportunity (P=.03) factors were more likely to indicate negative behavioral intentions.

CONCLUSIONS

Most behavioral intentions regarding COVID-19 vaccines were related to the motivation construct. The themes identified in this study could be used to inform theory-based and evidence-based interventions to improve acceptance of COVID-19 vaccines.
COVID Tongue: A new manifestation of COVID-19 – A Call to Action (Preprint)
Authors: Rajasekar Sakthi Jaya Sundar
Published: May 2021

UNSTRUCTURED

No abstract/not applicable
Absolvent_innen der Akademie Abschlussjahrgänge 2000-2018. Kurzbericht.
Authors:   Akademie der bildenden Künste - Abteilung Qualitätsentwicklung
Published: May 2021

Die Studie ist eine differenzierte Analyse der beruflichen Wege jener Absolvent_innen der Akademie, die ihr Bachelor-, Diplom- oder Masterstudium zwischen den Jahren 2000 und 2018 abgeschlossen haben. In der Studie steht die Sichtweise der Absolvent_innen – deren Selbstwahrnehmung und Selbsteinschätzung – im Vordergrund. Der Impact des Studiums auf den Werdegang der Absolvent_innen wird dabei besonders fokussiert. Dieser Bericht basiert auf der Studie "Studienerfahrungen, Tätigkeitsfelder und künstlerisches Selbstverständnis der Absolvent_innen der Akademie der bildenden Künste Wien (2000-2018)", die 2019/20 vom Zentrum für Soziale Innovation im Auftrag der Akademie der bildenden Künste Wien durchgeführt wurde
Lithic raw material in the Cantabrian region: Dialectical relationship between flint and quartzite in the Palaeolithic record
Authors: Prieto Alejandro , Arrizabalaga Alvaro , Yusta Iñaki
Published: May 2021

The increase, in quantitative and qualitative terms, of research attending to the geological nature of rocks found in archaeological contexts is changing our perspectives about social and economic territories articulated by Palaeolithic societies in the Cantabrian Region. Practically the only raw material researched in a solid geoarchaeological approach in this area is flint. This paper addresses how the near absence of in-depth geoarchaeological research into raw materials other than flint is modifying our perception of the procurement and management mechanism of raw material in the Cantabrian Region during the Palaeolithic.

To consider this matter in depth, we present the bibliographic and quantitative analysis of 30 representative archaeological sites from the Cantabrian Region whose assemblages were described lithologically using basic and primary categories. The state of play depicts a geographic distribution of raw material in the Cantabrian Region where quartzite is associated with the western sector and flint with the east. Interconnected with this axis, there is a chronological tendency that promotes standardisation in the use of flint by Palaeolithic societies following a chronological order, from the older to the more recent periods. This information, and its contextualisation with the new perspectives resulting from the application of the geoarchaeological proposal used to understand flint procurement, allows us to understand the general tendencies of raw material distribution of the region. Especially, we can detect how the absence of geoarchaeological methodologies of other raw materials than flint has modified the perception of the economic and social dynamics articulated around raw material by Palaeolithic people. This bias does not only affect the geographical and chronological axes, emphasising information from the regions and periods where flint is represented, but also promotes the over-interpretation of long-distance procurement, therefore, building up narratives exclusively based on human mobility.

This situation has generated an incomplete and unbalanced picture of the procurement and management strategies followed by Palaeolithic societies because quartzite, the second most-often used lithic raw material, and other raw materials have only been studied using geoarchaeological methods within the last few years. This research finally points to the continuation of in-depth research of quartzite and other raw materials as the next steps to re-interpret the current paradigms about procurement and management of raw material by Palaeolithic societies, and, therefore, modify our perspectives of social and economic territories.
Búsqueda de zonas con tectonismo extremo, teoría y una aplicación a la geotermia: Caldera Los Humeros
Authors: Del Rio L. L.
Published: May 2021

Se presenta un método que analiza estadísticamente algunos de los elementos que componen la tectónica de una región, se formula una definición cuantitativa de alineamiento de objetos y se hace una aplicación a la geotermia. El objetivo de este método es señalar los principales sistemas de fracturamiento, las características del vulcanismo en una región, y poder indicar las partes de la misma en las cuales los procesos tectónicos han tenido una intensidad significativamente mayor, o menor, que la común en la misma. Todo ello tratado de manera cuantitativa. La región estudiada en la aplicación está limitada por los meridianos 96º y 99º0 y los paralelos 18º y 21ºN. Está localizada en la parte este de la Faja Volcánica Transmexicana y la corta la Sierra Madre Oriental. En dos aplicaciones sucesivas del método, se encontró que las zonas de 78 km2, con tectonismo intenso son, la correspondiente a los domos Las Derrumbadas y, con tectonismo singularmente intenso, las zonas aledañas al poblado Los Humeros y al Cerro Xalapazco, ambas en la parte centro-sur de la Caldera.
Estudio gravimétrico en la zona geotérmica de La Presita, Culiacán, México
Authors: García J: , Fernández R. , Vazquez R.
Published: May 2021

En 1981 se llevó a cabo un levantamiento gravimétrico en la zona geotérmica de La Presita, cerca de la ciudad de Culiacán, Sinaloa, México. Se estableció un total de 306 puntos de medición en una área aproximada de 290 km2 . Los datos fueron reducidos y procesados mediante una serie de algoritmos computacionales que se describen con detalle en este trabajo. La interpretación se llevó a cabo utilizando una técnica de inversión bidimensional. Inferimos de ella la presencia de un pilar de rumbo N-NO, que domina estructuralmente a la zona. Hacia el oeste de la zona, el relieve de la estructura del basamento sugiere la presencia de una falla normal que no tiene evidencia superficial, pero concuerda con los sistemas de fallas y fracturas que se observan regionalmente. Hacia el E, el pilar se encuentra limitado por la cuenca (Fosa) del río Humaya, donde se estima un grosor de sedimentos de hasta 1 km. Tenemos poca evidencia, pero estimamos que esta estructura se continúa hacia el sur de la zona. La zona geotérmica de La Presita está caracterizada por un sistema de fallas normales que sirven de conducto, a la superficie, a las aguas termales. Sin embargo, no tenemos suficiente evidencia geofísica para poder inferir la presencia de un cuerpo anómalo a profundidad.
A DEIXIS ANALYSIS OF SONG LYRICS IN HELLO BY ADELE
Authors: Kurniati Nia , Haryudun Acep
Published: May 2021

The main purpose of this research is to analyze three types of deixis in Adele’s song lyrics. Then, the song lyrics can be analyzed using pragmatic approach, especially about deixis. Then, the song lyrics can be analyzed using pragmatic approach, specifically about deixis. This research applied descriptive qualitative methodThis research applied descriptive qualitative method. The researcher elects lyrics of the most popular songs of Adele’s Album 25. The data ware taken from one of three song lyrics in Adele’s album 25 entitled Hello for identifying and classifying the deixis into their types (person deixis, spatial deixis, and temporal deixis). Based on the results and discussion can be concluded that all deixis found in song lyrics, there are 53 words include of kinds of deixis. the person deixis was found on  adele’s song as the most dominant type (43 deictic words or 75%). Second position, deixis spatial is the most found (9 deictic words or 17%), and in the last position is temporal deixis (4 deictic words or 8%)
EXPLORING THE POTENTIALS OF TECHNOLOGY INTEGRATION FOR TEACHING LANGUAGE SKILLS: A LITERATURE REVIEW
Authors: Syathroh Isry Laila , Kareviati Evie , Lestari Ayu , Fitria Nurlaila
Published: May 2021

The use of technology has become an essential element in teaching and learning process. Usually, each language class uses some type of technology tools that are used to support and enhance language learning. They are tools to help teachers facilitate their students' language learning. This research focuses on the role of technology in learning English as a foreign and second language. It addresses the significance of technology that allows English language learners to develop their learning abilities. In this paper, the researchers describe the term technology integration,  of technology, explain the use of technology in the language classroom, discuss the advantages and challenges of technology integration, and provide some suggestions for better use of these technologies to help learners develop their learning abilities.
CODE SWITCHING UTTERANCES OF PUBLIC FIGURES’ VLOG IN YOUTUBE CHANNEL
Authors: Tussa'diah Halimah , Anggaini Eka , Hasibuan Selamat Husni
Published: May 2021

This research dealt with the analysis of Code-Switching Utterances of Public Figures’ Vlog In YouTube Channel. The objectives were to determine code-switching and the types of code-switching used by the public figures and the guests. The researcher focused on the application of Intra- sentential (74 cases), Inter-sentential (85 cases) and Extra/Tag code-switching (26 cases). A descriptive qualitative method was taken to analyze the data from four videos on YouTube published in March 2019 until November 2019. The finding showed that public figures and the guests used code-switching, which included 185 cases. There were seven reasons of public figures switched the language; 75 data of talking about a particular topic, 2 data of quoting somebody else, 1 data of  being emphatic about something, 13 data of interjection (inserting sentence filler or sentence connector), 27 data of repetition of clarification, 63 data of intention for clarifying the speech content for the interlocutor, and 4 data of expressing group identity.
ANALYSIS OF EDUCATION VALUE OF CHARACTER IN NOVEL 5 CM BY DONNY DHIRGANTORO
Authors: Sembiring Rut Leni Natalia , Br pakpahan Emma Martina
Published: May 2021

Character education is closely related to moral education, which is to shape and train individual abilities continuously for self-improvement towards a better life. Novel is a literary work that can convey the values of character education. The research aims to analyzing the values of character education in the novel 5 cm by Donny dhirgantoro. This research is a qualitative study using a descriptive design method. the data analysis technique by reading the entire data, analyzing the data in more detail and restating the data by described and interpreting the data. The result of this study are the value of character education  contained in the novel “ 5 cm” by Donny Dhirgantoro, namely, religious, hard work, love to read, friendly and communicative, social care,  and love  the homeland.
Políticas Públicas e Docência no contexto da Pandemia no Norte do Brasil
Authors: Soares Lucas de Vasconcelos , Colares Maria Lília Imbiriba Sousa
Published: May 2021

O estudo apresenta discussões sobre a dinâmica do ensino remoto – introduzida no curso de uma pandemia – nas instituições públicas de ensino, e os efeitos desta organização na docência, refletindo o papel das políticas públicas neste processo de mudanças e novos percursos. Utiliza-se como lócus de problematização o contexto educacional da região norte do Brasil. As discussões são fruto de uma pesquisa empírica, contemplando o uso de levantamento bibliográfico-documental, observação e aplicação de entrevistas semiestruturadas com docentes da Educação Básica por meio de formulário eletrônico. Inicialmente, contempla-se que a pandemia introduziu novas demandas e intensificou esforços, aos docentes, diante da organização da dinâmica educativa, desde a adaptabilidade às ferramentas tecnológicas disponíveis até a transposição de metodologias presenciais para o ambiente virtual, bem como ocasionou a expansão da carga horária de trabalho, desmotivação e conflitos com as famílias dos estudantes. Soma-se a isso, o enfraquecimento da oferta de formação para o novo contexto educacional. Assim, é notável que, além de ampliar os dilemas já existentes, a pandemia projetou ainda o desafio da (re)invenção do fazer docente numa atual conjuntura de crise na educação pública, com desarticulações entre as políticas públicas educacionais e o novo contexto, principalmente, no norte do Brasil.
Democracia e Estado moderno no contexto global: dilemas e contradições
Authors: Conceição Silvano da , Leme Alessandro André
Published: May 2021

O presente texto é fruto de reflexões em torno da temática da Democracia e do Estado Moderno, bem como os principais desafios que emergem nas sociedades contemporâneas a partir da evolução tanto da Democracia como do próprio Estado Moderno. Para o desenvolvimento de tal discussão optou-se por percorrer um itinerário que investigou desde as discussões clássicas sobre as temáticas propostas, passando pelas abordagens de alguns teóricos dos séculos XIX e XX, chegando as formulações de autores contemporâneos. Temas como liberalismo, globalização, mundialização, capitalismo acabaram também sendo arrolados no presente texto, na medida em que são temas fundamentais para desenvolvermos uma análise mais completa em torno das duas temáticas, a saber: Democracia e Estado- Moderno.
Non-pharmacological aids for patients suffering from narcolepsy with cataplexy (White Paper 2021)
Authors: Diamandis Dr. Carolina , Adams Jacob S. , Papadopoulos Anastasios , Honda Riku , Seideman David
Published: May 2021

Narcolepsy with cataplexy is an often underestimated disorder in both
its primary and secondary forms. As with epilepsy, narcolepsy and
cataplexy pose a high risk of injury to the patient. Yet, narcoleptics
have historically received poorer care than epileptics with regard to
non-pharmacological aids. This “White Paper” informs both
professionals and patients about protective measures that are advisable.
Migratory fishbones in the pharynx: a report of two cases
Authors: Xu Shuyi , Li Xiaomin , Peng Yue , Yang Jing , Liu Qianxu , Guo Jiefeng , Yu Zhijian
Published: May 2021

Fishbones migrated into surrounding tissues is relatively unusual. We
present two cases of patients’ migratory fish bones into the
retropharyngeal space and hypopharynx. All fishbones were removed
without complications. Early diagnosis of migratory fishbone and
therapeutic management are essential for optimal patient survival.
Dve bronzovye kadil'nicy iz Nacional'nogo muzeja Gruzii
Authors: Macabeli Kitti
Published: May 2021

The present paper examines two bronze censers with Christological relief
compositions from the Georgian National Museum. The analyses of their
stylistic and iconographic features shed more light on the dissemination of
the bronze censers produced in the East Christian artistic centers. The
paper attempts to determine the time and place of creation of these
liturgical objects. I will also offer some observations concerning the
relationship between metal incense burners of Syro-Palestinian origin and
those made in different places throughout Christendom.
Tissue-Specific Splicing and Dietary Interaction of a Mutant As160 Allele Determine Muscle Metabolic Fitness in Rodents
Authors: Yang Xinyu , Chen Qiaoli , Ouyang Qian , Rong Ping , Feng Weikuan , Quan Chao , Li Min , Jiang Qing , Liang Hui , Zhao Tong-Jin , Wang Hong Yu , Chen Shuai
Published: May 2021

Ethnic groups are physiologically and genetically adapted to their diets. Inuit bear a frequent AS160R684X mutation that causes type 2 diabetes. Whether this mutation evolutionarily confers adaptation in Inuit and how it causes metabolic disorders upon dietary changes are unknown due to limitations in human studies. Here, we develop a genetically modified rat model bearing an orthologous AS160R693X mutation, which mimics human patients exhibiting postprandial hyperglycemia and hyperinsulinemia. Importantly, a sugar-rich diet aggravates metabolic abnormalities in AS160R693X rats. The AS160R693X mutation diminishes a dominant long-variant AS160 without affecting a minor short-variant AS160 in skeletal muscle, which suppresses muscle glucose utilization but induces fatty acid oxidation. This fuel switch suggests a possible adaptation in Inuit who traditionally had lipid-rich hypoglycemic diets. Finally, induction of the short-variant AS160 restores glucose utilization in rat myocytes and a mouse model. Our findings have implications for development of precision treatments for patients bearing the AS160R684X mutation.
Genetic Evidence for Different Adiposity Phenotypes and Their Opposing Influences on Ectopic Fat and Risk of Cardiometabolic Disease
Authors: Martin Susan , Cule Madeleine , Basty Nicolas , Tyrrell Jessica , Beaumont Robin N. , Wood Andrew R. , Frayling Timothy M. , Sorokin Elena , Whitcher Brandon , Liu Yi , Bell Jimmy D. , Thomas E. Louise , Yaghootkar Hanieh
Published: May 2021

To understand the causal role of adiposity and ectopic fat in type 2 diabetes and cardiometabolic diseases, we aimed to identify two clusters of adiposity genetic variants: one with “adverse” metabolic effects (UFA) and the other with, paradoxically, “favorable” metabolic effects (FA). We performed a multivariate genome-wide association study using body fat percentage and metabolic biomarkers from UK Biobank and identified 38 UFA and 36 FA variants. Adiposity-increasing alleles were associated with an adverse metabolic profile, higher risk of disease, higher CRP, and higher fat in subcutaneous and visceral adipose tissue, liver, and pancreas for UFA and a favorable metabolic profile, lower risk of disease, higher CRP and higher subcutaneous adipose tissue but lower liver fat for FA. We detected no sexual dimorphism. The Mendelian randomization studies provided evidence for a risk-increasing effect of UFA and protective effect of FA for type 2 diabetes, heart disease, hypertension, stroke, nonalcoholic fatty liver disease, and polycystic ovary syndrome. FA is distinct from UFA by its association with lower liver fat and protection from cardiometabolic diseases; it was not associated with visceral or pancreatic fat. Understanding the difference in FA and UFA may lead to new insights in preventing, predicting, and treating cardiometabolic diseases.
Laboratory tests and analysis of CIPP epoxy resin internal liners used in pipelines – part II: comparative analysis with the use of the FEM and engineering algorithms
Authors: Abel Tomasz
Published: May 2021

In the case of underground network infrastructure it can be seen that objects functioning in the second technical condition, according to DWA-ATV 143-2, and subjected to rehabilitation with the use of close-fit trenchless technologies are capable of withstanding external loads. The main external load that is taken into account in engineering calculations in the case of conduits in the second technical condition is external groundwater pressure.

In order to compare design parameters obtained with the use of various calculation methods, a comparative analysis was conducted in order to determine the values of critical pressure. The calculations were carried out using popular engineering algorithms.

In addition, analyses using the Finite Element Method and Abaqus software as a computational tool were carried out for the purpose of verifying laboratory tests. This paper aims to broaden knowledge concerning the possibility of performing control numerical analyses for close-fit liners installed in pipelines that are in the second technical condition according to DWA-ATV 143-2.

The analyses were carried out on ten 3D models. The models were parameterized in order to reflect the CIPP samples in the most accurate way. The computational models were built based on assumptions, which are commonly used in this type of scientific analysis, regarding material parameters and their interactions.

The direct value of the performed engineering calculations and numerical analyses is the extension of knowledge in the field of strength parameters that are obtained by various material groups of close-fit liners. Comparative analysis of the results of laboratory tests and numerical analyses, and the conclusions that result from them, constitute the basis for the optimization of the design process and the individual approach to issues related to the use of liners that strengthen underground pipelines.
Fungsi Signage Mcdonald’s Drive Thru dalam Perspektif Sosial Budaya
Authors: Noordyanto Naufan
Published: May 2021

Layanan drive thru yang ditawarkan McDonald’s rupanya menjadi alternatif pilihan masyarakat. Untuk mengidentifikasinya, McDonald’s memasang salah satu media komunikasi visual, yaitu signage bertanda drive thru yang terpancang di tepi jalan kota yang erat merespon pola-pola kebiasaan: mobilitas pengendara/pengguna jalan (masyarakat urban). Karenanya, kehadiran signage ini diasumsikan berkontribusi dalam memberi pengaruh pada sendi-sendi kehidupan sosial budaya masyarakat. Penelitian ini menyelidiki fungsi signage McDonald’s drive thru dalam perspektif sosial-budaya. Studi dilakukan dengan kajian pustaka dan lebih ditekankan pada analisis deskriptif kualitatif berkaitan dengan fungsi signage McDonald’s drive thru yang berpotensi menciptakan dampak sosial, gaya hidup, budaya konsumsi dan komersial. Analisis lebih ditekankan pada implikasi sosial budaya dari objek desain dengan tujuan desain. Fungsi signage McDonald’s drive thru sebagai media komunikasi visual (promosi luar ruang) diketahui tidak hanya dipahami secara tekstual saja, yaitu kaitannya dengan fungsi pemasaran, namun juga mempromosikan McDonaldisasi, kapitalisme, konsumerisme, modernisasi, gaya hidup pop dan pop art, serta kehidupan urban.
Sęp, czyli o ciemnej stronie współczesnego reportażu
Authors: Popławska Joanna
Published: May 2021

DOI 10.24917/20837275.10.2.7Głównym celem reportera / fotoreportera jest uchwycenie interesującego, szokującego materiału, który mógłby mieć wpływ na emocje czytelnika. To dlatego bieda, cierpienie i śmierć stają się najważniejszymi tematami, a reporter podąża ich ścieżką, bez względu na to, czy takie działania wydają się moralne, czy nie. Wówczas jednak pisarz może łatwo stracić z oczu swój główny cel, człowieka. Człowieka, który odsłania całą nagą prawdę, odsłania cierpienie, mając nadzieję na poprawę swojego losu istoty, by na koniec zostać porzuconym przez reportera i stać się po prostu jeszcze jedną dobrze sprzedaną historią. Celem mojego artykułu będzie przyjrzenie się amoralnej postawie reportera i relacji: reporter / fotoreporter – główny bohater tekstu. Analiza oparta będzie na najnowszej książce Wojciecha Tochmana – Eli, Eli. Aby bardziej uwypuklić główną tezę artykułu, współczesny reportaż skonfrontowany został z tym z okresu międzywojennego, reprezentowanym przez pionierów reportażu społecznego – Irenę Krzywicką i Wandę Melcer. Celem artykuły jest wskazanie ewolucji gatunku, jego transformacji i ich przyczyn.A Vulture – the Dark Side of Contemporary ReportageThe main goal of a reporter / photojournalist is to capture some interesting, shocking material, one that would affect the emotions of a reader. Therefore, poverty, suffering and death become the most important, and the reporter follows their path no matter whether such actions seem moral or not. The writer might then easily lose the main focus, a man. A man who reveals all the naked truth, uncovers the suffering, hoping to improve his or her being. At the end, such people are abandoned by the reporter and they become just a well-sold history. The purpose of my paper will be to look closer at the amoral attitude of a reporter and the relationship: reporter/ photojournalist – the main character of a text. My analysis will be based on Wojciech Tochman’s latest reporter’s book – Eli, Eli. To prove my thesis more distinctly, I will confront the contemporary reportage with the one from the Interwar period represented by the pioneers of social reportage – Irena Krzywicka and Wanda Melcer. My goal will be to indicate the evolution of the genre, its transformations and their causes.
Active Knowledge Extraction from Cyclic Voltammetry
Authors: Vaddi Kiran , Wodo Olga
Published: May 2021

Cyclic Voltammetry~(CV) is an electro-chemical characterization technique used in an initial material screening for desired properties and to extract information about electro-chemical reactions.

In some applications, to extract kinetic information of the associated reactions (e.g., rate constants and turn over frequencies), CV curve should have a specific shape (for example an S-shape). However, often the settings to obtain such curve are not known \textit{a priori}. In this paper, an active search framework is defined to accelerate identification of settings that enable knowledge extraction from CV experiments.Towards this goal, a function space representation of CV responses is used in combination with Bayesian Model Selection (BMS) method to efficiently label the response to be either \textit{S-shape} or not \textit{S-shape}. Using an active search with BMS oracle, we report a linear target identification in a 6-dimensional design space (comprising of thermodynamic, mass transfer and solution variables as dimensions). Our framework has the potential to be a powerful virtual screening technique for molecular catalysts, bi-functional fuel cell catalysts etc.
High Shear in Situ Exfoliation of 2D Gallium Oxide Sheets from Centrifugally Derived Thin Films of Liquid Gallium
Authors: Vimalanathan Kasturi , Palmer Timotheos , Gardner Zoe , Ling Irene , Rahpeima Soraya , Elmas Sait , Sun Qiang , Gascooke Jason R. , Gibson Christopher T , Zou Jin , Anderson Mats R. , Darwish Nadim , Raston Colin
Published: May 2021

Herein, we have explored the use of a microfluidics platform for the exfoliation and oxidation of liquid gallium into ultrathin sheets of gallium oxide under continuous flow condition. The novel method developed here takes advantage of the high mass transfer in liquids and has the potential for creating high yielding thin sheets of oxidised gallium with insulating properties as well as acts as an active catalyst in hydrogen evolution reactions. This highlights the potential utility of the sheets as an alternative to the expensive and scarce noble metal based electrocatalysts