bluuebunny/crossref_metadata_2025 huggingface dataset:
Strategi Pembelajaran Pendidikan Agama Kristen Pada Orang Dewasa
Authors: Sibuea Ezra Yani , Arifianto Yonatan Alex , Rusmiati Rusmiati
Published: March 2023

Christian religious education is not education that only talks about children. Christian religious education in the aim of maturing faith is also needed in the world of adults who are faced with various decisions and problems of life and the demands of their lives. Therefore the strategy in learning Christian religious education for adults is important. There are many learning methods, but there are several learning methods for adults that can be used by educators and church administrators, namely the method Jesus also used in teaching. This study aims to describe the learning strategy of Christian religious education for adults with a qualitative approach. The data collection was carried out by conducting a study of library sources related to the discussion in this paper. The results of this study indicate that the learning strategies that Jesus previously used can also be used in teaching Christian religious education for adults.AbstrakPendidikan Agama Kristen bukanlah pendidikan yang hanya berbicara mengenai anak-anak saja. pendidikan Agama Krsiten dalam tujuannya mendewasakan iman juga diperlukan dalam dunia orang dewasa yang diperhadapkan oleh berbagai keputusan dan permasalahan hidup serta tuntutan kehidupannya. Maka dari itu strategi dalam pembelajran pendidikan agama Krsiten bagi orang dewasa merupakan hal yang penting. Ada banyak metode pembelajaran namun ada beberapa metode pembelajaran bagi orang dewasa yang bisa dipakai oleh pendidik maupun pengurus gereja yaitu metode yang juga dipakai oleh Yesus dalam memberikan pembelajaran. Penelitian ini bertujuan untuk mendeskripsikan mengenai trategi pembelajaran pendidikan agama Krsiten bagi orang dewasa dengan pendekatan kualitatif. Pengumpulan data dilakukan dengan melakukan kajian terhadap sumber-sumber pustaka yang berkaitan dengan pembahasan dalam tulisan ini. Hasil penelitian ini menunjukkan bahwa strategi pembelajaran yang dilakukan Yesus sebelumnya juga dapat dipakai dalam pembelajaran pendidikan agaram Kristen bagi orang dewasa.
Peran Keluarga Kristen dalam Penanganan karakter Anak-anak di Era Digitalisasi
Authors: Saputro Albertus Kurniadi
Published: March 2023

Continuous use of gadgets will have a negative impact on children's behavior patterns in their daily lives so that children who tend to continuously use gadgets become an addiction that greatly affects their life and development. Using descriptive qualitative methods with a literature approach, it can be concluded that the role of Christian families in handling children's character in the digitalization era can be done by, firstly providing education on the impact of excessive use of gadgets, secondly the role of families and handling children's characters becomes a priority in dealing with it. Through the example of parents in educating their children, this is done by positioning the family in a biblical perspective and providing assistance to the dangers of the digital world.AbstrakPenggunaan gadget secara terus menerus akan berdampak buruk bagi pola perilaku anak dalam kesehariannya sehingga anak-anak yang cenderung terus menerus menggunakan gadget sehingga menjadi candu yang sangat memengaruhi kehidupan dan perkembangannya. Mengunakan metode kualitatif deskritif dengan pendekatan literatur maka dapat disimpulkan  bahwa peran keluarga Kristen dalam penanganan karakter anak-anak  di era digitalisasi dapat dilakukan dengan, Pertama memberikan edukasi adanya Dampak Pengunaan Gadget secara berlebihan, kedua peran Keluarga dan Penangan Karakter Anak menjadi prioritas dalam menanganinya. Melalui cara Keteladanan Orang Tua dalam mendidik Anak yang dikerjakan dengan Memposisikan Keluarga dalam Persepektif Alkitabiah dan Memberikan pendampingan terhadap bahaya dunia digital.
Peran Gereja dalam Aktualisasi Amanat Agung bagi Msyarakat di Era Dunia Digital
Authors: Berhitu Reinhard
Published: March 2023

The reluctance of believers as part of God's church in evangelizing comes from the church itself which does not place evangelism as a priority in church growth. Even the problem that often occurs is that believers are deceived by persuasion from other pastors who use unethical methods so that the congregation moves and becomes new followers in other churches. Moreover, the complexity of the impact of technological advances and informatics must also force Christianity to continue to carry out missions in the digital world though. It can be concluded that the Church's Role in Actualizing the Great Commission for society in the era of the digital world. Believers must have Synergy as part of the Church and the Great Commission to work together to build impact for the Gospel in a Digital World. Believers must be present for those who do not know Jesus and preach by all means to convey the news of salvation for humans even in the digital world. Furthermore, the role of believers in the actualization of the gospel in the Digital Age is highly anticipated and becomes a definite answer for those who are connected with advances in technology and informatics.AbstrakKeengganan orang percaya sebagai bagian dari gereja Tuhan dalam menginjil datang dari persoalan gereja sendiri yang tidak menempatkan penginjilan sebagai prioritas dalam pertumbuhan gereja. Bahkan persoalan yang sering terjadi orang percaya terpedaya karena bujuk rayu dari gembala lain yang menggunakan cara-cara kurang etis sehingga jemaat itu pindah dan menjadi pengikut baru digereja lain. Terlebih kompleknya dampak dari kemajuan teknologi dan informatika juga harus memaksa kekristenan untuk terus melakuakn misi di dunia digital sekalipun. Dapat disimpulkan bahwa peran gereja dalam aktualisasi Amanat Agung bagi masyarakat  di era dunia digital. Orang percaya harus memiliki Sinergisitas sebagai bagian dari Gereja dan Amanat Agung untuk bekerja sama membangun dampak bagi Injil dalam Dunia Digital. Orang percaya wajib hadir bagi mereka yang belum mengenal Yesus dan memberitakan dengan segala cara untuk menyampaikan kabar keselamatan bagi manusia sekalipun di dunia digital. Selanjutnya Peran Orang Percaya dalam Aktiualisasi Injil di Era Digital sangat dinanti dan menjadi jawaban pasti mereka yang terhubung dengan kemajuan teknologi dan informatika.
Peran Guru Pendidikan Agama Kristen Terhadap Kesiapan Siswa dalam Menghadapi Bonus Demografi
Authors: Kaka Paulina Bura , Kristiani Dina
Published: March 2023

The Demographic Bonus is a phenomenon that will occur in Indonesia in2030-2045 and will have an impact on all people’s lives. This phenomenon requiresthe role of all levels of society, including teachers. This article aims toprovide an understanding of the teacher’s role in students’ readiness to facedemographic bonuses in Indonesia. The liberation in this paper uses a qualitativeapproach with literary review writing techniques or library studies. The results of thestudy show that teachers must play a role in dealing with demographicbonuses through the pillars or functions of teachers/teaching sir. Teachers can carryout various concrete actions that are holistic which can be useful in all aspects ofstudent and community life. In this case, the teacher must be the guardianof the student who warns the student of all life’s problems, not only spiritualproblems. This research has a contribution for students to play an active role in thewhole life of the participants. Teachers do not only focus on teaching in schools butmust be able to touch all aspects of the lives of students and society.AbstrakBonus demografi adalah fenomena yang akan terjadi di indonesia pada tahun 2030-2045 dan akan berdampak pada seluruh kehidupan masyarakat. Fenomena ini membutuhkan peran seluruh lapiran masyarakat termasuk guru. artikel ini bertujuan untuk memberikan pemahaman tentang peran guru terhadap kesiapan siswa  dalam menghadapi bonus demografi di indonesia. Pembahasan dalam tulisan ini menggunakan pendekatan kualitatif dengan teknik penulisan literature review atau studi pustaka. hasil penelitian menunjukkan bahwa guru pak harus berperan dalam menghadapi bonus demografi melalui pilar atau fungsi guru/pengajar pak. guru dapat melakukan berbagai aksi nyata yang bersifat holistik yang dapat berguna dalam seluruh aspek kehidupan siswa dan masyarakat.dalam hal ini, guru harus menjadi penjaga siswa yang memperingatkan siswa atas seluruh permasalah kehidupan tidak hanya masalah rohani. penelitian ini memiliki kontribusi bagi peserta didik untuk berperan aktif dalam seluruh kehidupan peserta. guru tidak hanya berfokus pada pengajaran di sekolah tetapi harus dapat  menyentuh seluruh aspek kehidupan peserta didik dan masyarakat.
An Analysis of the Existing Form of Governance Politics in Zimbabwe and Proposals for a New Kind of Policymaking
Authors:   Mass Public Opinion Institute, Masunungure Eldred , Zvoushe Hardlife ,   University of Zimbabwe
Published: March 2023

This article analyses Zimbabwe’s existing governance politics, specifically focusing on the politics of policy making. We argue that the existing form of governance politics in Zimbabwe is characterised by the vertical modality of rule whereby policies are crafted unilaterally at the apex of the party state with little or no input from affected stakeholders – including ordinary citizens - and then fed to citizens who are therefore treated as dispensable policy takers. We further argue that the current forms of politics and policymaking are similarly exclusionary in nature, relying on centralised governance approaches where the central government and the ruling party unilaterally make governance decisions and formulate policy without consulting citizens and other key stakeholders. Finally, we propose the adoption of a ‘distributed problem-solving model’ which acknowledges and prioritises the unique needs and interests of different social groups in governance and policy making.
Seed vitality of sunflower inbred lines influenced by meteorological factors and seed size
Authors: Krstić Miloš , Ovuka Jelena , Gvozdenac Sonja , Butaš Daliborka , Ćuk Nemanja , Babec Brankica , Cvejić Sandra
Published: March 2023

Climate changes inevitably affect plant production, but it is difficult to predict their direct impact on a vitality (germination) of a produced seed. Germination is the most important indicator of seed vitality and a key stage in the life cycle of plants. Seed germination is significantly affected by environmental factors during the growing season, as well as the method of processing (according to seed size). The aim of this work was to determine the impact of three factors on seed germination of four sunflower inbred lines: i) genotype, ii) environment conditions in a production year, and iii) seed size obtained during processing. The germination was examined in a standard laboratory test by ISTA Ruls, six months after the processing and natural breaking of dormancy. Larger and smaller sizes seeds, obtained in two consecutive years, which were characterized by different environmental conditions (sum of precipitation, mean monthly temperatures and air humidity during flowering), were used. Collected data was analyzed using a three-way analysis of variance, and correlation analysis. The coefficient of variation was 8.19%. Significantly higher average seed germination was obtained during 2020 (92%,) compared to 2021 (85%). The effect of seed size was not statistically significant, regardless of the tested inbred line. It can be concluded that the increase in the seed germination of sunflower inbred lines is mainly influenced by genotype, but also the increase in precipitation, minimum and maximum air humidity during flowering and the decrease in mean monthly temperatures, which was confirmed by the correlation coefficients between the above agroecological conditions and the germination rate of the produced seeds.
Business process redesign as a basic aspect of digital business transformation
Authors: Ivanišević Rajko , Horvat Danijel , Matić Milenko
Published: March 2023

Background: It is widely accepted that the digital transformation of business is increasingly attracting the attention of researchers from the academic circles as well as professionals from the business community. The main consequence of this lies in the daily development of new and improvement of existing digital technologies. The outcomes of such events on the market are reflected in all aspects of companies' operations. For this reason, they are constantly looking for various improvements to their business, which most often include the implementation of new technology. Mere implementation of a new technology without any other changes very often leads to failure. The core of this failure can be found and attributed to inadequately identified, analysed, documented and established business processes. Business process management (BPM) and redesign as its integral part are actually an indispensable segment of a successful process of digital business transformation. Therefore, the digital transformation of business should not be viewed exclusively from a technological perspective, but also from a process viewpoint. Purpose: With the aim of shedding additional light on the connection between business process management and digital business transformation, the paper aims to identify and explain the importance of business process redesign. Study design/methodology/approach: For the purposes of this paper, a systematic literature review was conducted. Findings/conclusions: The result of the conducted research indicates that a process approach to the digital transformation of business can contribute to significantly different, more successful results. Limitations/future research: Limitations refer to the number of databases searched during this systematic literature review. Subsequent research could include additional sources that would include additional works that can contribute to a better research result.
Restrictions on human rights under the European Convention of Human Rights and fundamental freedoms: New tendencies
Authors: Toroman Aleksandra
Published: March 2023

The majority of human rights can be restricted in certain situations, despite their significance for every democratic society. That means that those rights are not absolute. Such situations represent, for example, war and states of emergency, according to the European Convention on Human Rights. Then, in order to protect the interest of the state and national security, human rights, that means the interests of individuals, come second. In that case, it is necessary to achieve a balance between the necessary restrictions and the preservation of the state's interests. One of the best examples of the restrictions of human rights during a state of emergency is the period of Covid-19. Many rights, such as the right to respect for private and family life, were restricted during Covid-19 in a number of countries in Europe, but each country established its own measures according to its own situation. The cases regarding these restrictions and violations will be submitted to the European Court of Human Rights in the years to come.
The characteristics of misdemeanor prosecution according to the Law on Tax Procedure and Tax Administration
Authors: Milić Ivan
Published: March 2023

After a misdemeanor and its perpetrator are discovered, the prosecution of the misdemeanor is initiated. Pursuant to the Misdemeanor Law either a request for initiation of a misdemeanor procedure is submitted against the defendant, or a misdemeanor warrant is issued. Without an "initiation act", a misdemeanor procedure cannot be pursued. In the current Law on Tax Procedure and Tax Administration there are certain specifics concerning the procedure for pursuing defendants of tax misdemeanors. The author focuses on examining the characteristics of this procedure.
Austrian administrative judiciary: The reform and the new paradigm
Authors: Radošević Ratko
Published: March 2023

In 2012, a major reform of the Austrian administrative judiciary has been completed. The reform is analysed in this paper after a brief presentation of the origin and development of the Austrian administrative judiciary and its classical, traditional features. The analysis includes the reasons and motivation for the reform, its course and the basic characteristics of the newly implemented system. At the end, it is concluded that the introduction of a two-level administrative judiciary, an administrative dispute of full jurisdiction and the abolition of appeals in administrative procedure in Austria have changed the paradigm of the legal protection of parties in administrative matters.
Tax reliefs for employment of new residents
Authors: Baturan Luka , Milošević Goran , Cvjetković-Ivetić Cvjetana
Published: March 2023

The paper analyzes the tax relief for employment of new residents. In the first two parts, there is a legal analysis of Art. 15c of the Law on Personal Income Tax and Art. 15a of the Law on Contributions for Mandatory Social Insurance. Then, this tax relief will be examined in the context of the principles of tax law and public finance, especially the principle of tax fairness, the principle of tax efficiency and the principle of the stability of the tax system. The conclusion is that the problem of the outflow of highly skilled workers could not be solved by partial reforms of tax laws. A systematic solution implies a radical reform of the personal income tax, which would be firmly based on the principles of tax law and tax science.
Factores de riesgo y de protección asociados al trastorno obsesivo-compulsivo en niños y adolescentes: Una revisión sistemática
Authors: Pardo Maria , Sandín Bonifacio , Valiente Rosa M. , Chorot Paloma
Published: March 2023

Risk and protective factors associated with obsessive-compulsive disorder in children and adolescents: A systematic review
Abstract: The aim of this systemic review was to examine the risk and protective factors associated with obsessive-compulsive disorder (OCD) and symptoms of OCD in children and adolescents. We conducted a literature search using Scopus, PsycINFO, ScienceDirect and PubMed. A total of 25 published studies were included in the review. We examined all possible risk and/or protective factors that were associated with OCD and/or OCD subclinical symptoms. Most of the revised studies were focused on risk factors and the OCD. We found several types of risk factors, including biological (genetic, perinatal, neurological, infectious, etc.), personal (anxiety sensitivity, negative affect, behavioral inhibition, sense of responsibility, etc.), familial (parenting behaviors, childhood trauma, etc.), socioeconomic, and psychosocial (stress, low social support etc.) factors. Resilience and high social support emerged as protective factors. These results highlight that various factors, especially risk factors, appear to be consistently associated with OCD, which could be incorporated into future prevention programs for this disorder.
 
Keywords: Obsessive-compulsive disorder; OCD symptoms; risk factors; protective factors; children; adolescents.
Resumen: El objetivo de esta revisión sistemática fue examinar los factores de riesgo y de protección asociados al trastorno obsesivo-compulsivo (TOC) y a los síntomas del TOC en niños y adolescentes. Llevamos a cabo una búsqueda de la literatura a través de Scopus, PsycINFO, ScienceDirect y PubMed. Se incluyó en la revisión un total de 25 estudios publicados. Examinamos todos los posibles factores de riesgo y/o de protección que fueron asociados al TOC o a síntomas subclínicos del TOC. La mayor parte de los estudios revisados se focalizaron en factores de riesgo y en el TOC. Encontramos diversos tipos de factores de riesgo, incluyendo los factores biológicos (genéticos, perinatales, cerebrales, infecciosos, etc.), personales (sensibilidad a la ansiedad, afecto negativo, inhibición conductual, sentido de responsabilidad, etc.), familiares (estilos de crianza, trauma infantil, etc.), socioeconómicos, y psicosociales (estrés, bajo apoyo social, etc.). La resiliencia y el apoyo social elevado aparecieron como factores de protección. Estos resultados subrayan que varios factores, especialmente factores de riesgo, parecen estar asociados de forma consistente al TOC, los cuales podrían incorporarse en los futuros programas de prevención de este trastorno.
Palabras clave: Trastorno obsesivo-compulsivo; síntomas de TOC; factores de riesgo; factores de protección; niños; adolescentes.
A Study of Multiple Wave Probe Methods to Resolve Wave Reflections
Authors: Mullen Ashley N. , Koola Paul M. , Girimaji Sharath S.
Published: March 2023

Wave reflections are an important phenomenon for analyzing structures close to the coast. Wave energy structures increase the complexities of these measurements due to wave absorption. There have been numerous techniques developed to quantify wave reflections. Multiple wave probes have been used to resolve the incident and reflected wave components in the wave field. This paper attempts to validate the theory proposed by Lin and Huang (2004) that higher harmonic waves can be resolved using four wave gauges instead of traditional practice of three wave gauges which is unable to resolve higher wave harmonics. The results of this paper test the new technique by estimating the error bands for digitizing frequencies, noisy signals, and different wavelengths for a specific set of wave gauge spacing. The waves tested are artificially generated signals with known incident and reflected amplitudes with free and bound harmonic waves. This allows error estimations based on true values. After validation, we tested the technique with waves in a numerical wave tank (NWT). This comprehensive study of the multi-probe method proves the validity and provides limitations of using this technique for other ocean applications.
Results From The World's Largest Arctic Ships and Advancements of Propulsion Technology
Authors: Hanninen Samuli , Viherialehto Sampo , Heideman Torsten , Maattanen Pirjo , Arslan Ahmad
Published: March 2023

As a result of multi-year ice, shipping activity in Polar regions is growing. A completely new fleet of double-acting Arctic vessels has been developed and successfully proven their capabilities in the harshest environments. The size of Arctic vessels has also grown since the introduction of 172k Arctic icebreaking LNG carriers. Podded propulsion system is an attractive solution making these innovative ship concepts technically and commercially feasible. This paper will discuss practical experiences from Arctic LNG Carriers.

ABB Marine & Ports has further developed Azipod® propulsion concepts to meet the demands of even larger icebreaking vessels with high power requirements. This paper aims to present the key design factors when developing propulsion systems for high power icebreaking ships.

The largest podded drives for high ice class vessels have been up to 17MW. The new propulsion system has been developed to meet the market demand for a power range of up to 20MW. Scaling the range up offers considerable advantages for larger vessels. To mention a few the increased propeller size results in better hydrodynamic efficiency. Opportunities for increasing both the maximum bollard pull thrust and maximum over-torque both is another example. The unit will suit the highest ice class requirements such as IACS PC 1 and PC 2.

The propulsion system utilizes different operating modes to meet the vessel’s operational needs. In difficult ice conditions the Azipod can be operated in specialized ice mode. This gives a very robust and reliable operation to dynamic load variations caused by ice.

New technological solutions help ship owners to access opportunities in the Arctic regions by providing safe and reliable operation. The successful operational track record transporting LNG through NSR and Eastern Arctic offers proven propulsion solutions that can be used in Western Arctic energy projects as well. This paper will describe results from the world’s largest icebreaking vessels and the latest developments of the most powerful podded propulsion systems.
Seletividade de herbicidas pós-emergentes isolados ou associados a fertilizante foliar na cultura da soja
Authors: Alencar Erica da Silva de , Geist Mariana Lescano , Pereira João Paulo Morales , Schedenffeldt Bruna Ferrari , Nunes Felipe Alves , Silva Paulo Vinicius da , Dupas Elisângela , Mauad Munir , Monquero Patrícia Andrea , Medeiros Elias Silva de
Published: March 2023

A associação de herbicidas com fertilizantes foliares é comumente adotada na cultura da soja. Entretanto, essas associações podem ocasionar diferentes efeitos quando aplicadas na soja, necessitando portanto de maiores estudos. Assim, objetivou-se avaliar a seletividade de herbicidas pós-emergentes associados com fertilizante foliar (FF) à base de zinco na cultura da soja RR (resistente ao glifosato). O experimento foi conduzido em delineamento experimental de blocos casualizados, com quatro repetições. Os tratamentos aplicados foram chlorimuron (17,5 g i.a. ha-1); chlorimuron + FF (17,5 + 693 g i.a. ha-1); cloransulam (40 g i.a. ha-1); cloransulam + FF (40 + 693 g i.a. ha-1); fomesafem (225 g i.a. ha-1); fomesafem + FF (225 + 693 g i.a. ha-1); glyphosate (1.280 g i.a. ha-1); glyphosate + FF (1.280 + 693 g i.a. ha-1) e duas testemunhas sendo uma capinada e outra infestada. Foram realizadas avaliações visuais de fitotoxicidade aos 7, 14, 21, 28 e 35 dias após a aplicação dos tratamentos (DAT), e também nessas épocas os teores de clorofila. Ao final do ciclo da cultura foram determinados os dados referentes a produtividade e o peso de 1000 grãos. A fitotoxicidade foi superior a 30% quando se aplicou o cloransulam e o chlorimuron, enquanto que para o fomesafem e o glyphosate a fitotoxicidade foram próximas a 5%, na ausência ou presença do fertilizante foliar. Não ocorreu diferença significativa para a produtividade de grãos, peso de 1000 grãos e umidade. A associação de herbicidas com fertilizante foliar a base de zinco não influenciou na seletividade dos herbicidas aplicados em pós-emergência na cultura da soja RR.
Crescimento compensatório de alevinos de tilápia-do-Nilo submetidos à restrição alimentar e realimentação em temperaturas amenas
Authors: Braz Jaqueline Murback , Marques Agnes de Souza , Honorato Claucia Aparecida , Almeida Fernanda Losi Alves de , Neu Dacley Hertes
Published: March 2023

O objetivo do presente estudo é investigar o efeito de diferentes períodos de jejum alimentar e realimentação nas respostas compensatórias em alevinos de tilápias-do-Nilo, e a frequência de distribuição das fibras musculares. Foram utilizados 108 alevinos de tilápia-do-Nilo com peso inicial de 1,64±0,41 g e comprimento inicial médio de 3,60 ± 0,39 cm, durante um período de 55 dias. Os peixes foram distribuídos em um sistema de recirculação de água, em delineamento inteiramente casualizado com três tratamentos e quatro repetições: Controle - CO - (peixes alimentados até a saciedade aparente durante todo período experimental); jejum 10 - J10 - (peixes alimentados até a saciedade aparente por 15 dias, seguidos de 10 dias de jejum e realimentação até a saciedade por 30 dias); e jejum 15 - J15 - (peixes alimentados até a saciedade aparente por 15 dias, seguidos de 15 dias de jejum e realimentação até a saciedade por 25 dias). Os peixes do tratamento J15 apresentaram resultados insatisfatórios de desempenho produtivo (p<0,05), como menor peso final, conversão alimentar aparente, taxa de eficiência proteica e sobrevivência, enquanto os peixes do tratamento J10, atingiram os mesmos resultados daqueles animais mantidos no tratamento CO, com exceção das variáveis de ganho em peso relativo e do consumo de ração. A restrição alimentar influenciou diretamente no crescimento das fibras musculares com diâmetro menor que 20 μm (p<0,05), sendo que os peixes do tratamento J15 apresentaram a menor frequência de fibras nesta classe de diâmetro. Conclui-se que a restrição alimentar em curtos períodos (10 dias) e em temperaturas amenas podem apresentar um crescimento compensatório, alterando o processo de hiperplasia e hipertrofia das fibras musculares, sem afetar a morfologia das fibras, entretanto, 15 dias de jejum e sob temperaturas amenas não ocorre uma compensação no crescimento e atrasa o crescimento hipertrófico das fibras musculares.
Coloração da gema e análise sensorial de ovos de codornas europeias (Coturnix coturnix coturnix) alimentadas com ração à base de sorgo com adição de farelo de urucum (Bixa orellana L.)
Authors: Lima Daniela Nogueira , Carvalho Débora Cristine de Oliveira , Gois Glayciane Costa , Vieira Ariana Alves , Moraes Elenice Andrade , Antunes Karine Vieira , Queiroz Mário Adriano Ávila , Pinheiro Sandra Regina Freitas , Brito Claudson Oliveira
Published: March 2023

Objetivou-se avaliar o efeito de níveis crescentes do farelo do resíduo da semente de urucum (Bixa orellana L.) (FU), sobre a pigmentação da gema e análise sensorial dos ovos de codornas europeias alimentadas com dietas à base de sorgo em substituição ao milho. Foram utilizadas 80 codornas europeias (Coturnix coturnix coturnix) fêmeas, na fase de postura, no período de 251 a 316 dias de idade. Foram três períodos experimentais de 21 dias cada (251-272; 273-294; 295-316 dias). As codornas foram distribuídas em delineamento inteiramente casualizado, com cinco tratamentos (T1 - ração à base de milho; T2 - ração com 100% de sorgo em substituição ao milho sem a adição de FU; T3, T4 e T5 – ração com 100% de sorgo em substituição ao milho com a adição de 0,5; 1,0 e 1,5% de FU) e quatro repetições. Cem ovos de cada tratamento foram utilizados para a análise. A avaliação sensorial foi aplicada em painel não treinado de 20 avaliadores. Os ovos foram cozidos, descascados e servidos. A aparência, sabor, cor, odor, textura e avaliação global, foram avaliadas pelos painelistas. A farinha de semente de urucum adicionada à ração à base de sorgo promoveu aumentos lineares nos atributos aparência, sabor, cor, odor, textura e avaliação global, avaliados durante a análise sensorial (p=0,001). A adição de 1,5% de FU em dietas a base de sorgo beneficiou as características de aparência (4,50), sabor (4,50) cor (4,55), aroma (4,25) e textura (4,55) dos ovos de codorna avaliados, sendo considerados mais atrativos e com maior aceitação (avaliação global = 5,97), em relação aos demais tratamentos testados. A inclusão do FU nas rações à base de sorgo melhorou a pigmentação da gema dos ovos de codorna em relação aos tratamentos controle. O AM desencadeia efeitos positivos na pigmentação da gema e nas características sensoriais de ovos de codornas comuns.
Sunflower response to nitrogen doses
Authors: Lemos Petrônio , Pereira Rodrigo Gomes , Cavalcante Marcelo , Andrade Antônio Ricardo Santos de , Medeiros Preiscilla Vanúbia Queiroz de
Published: March 2023

The sunflower is an oilseed species, rustic, cultivated in different agroecosystems. The responses of cultivars to nitrogen fertilization vary according to the cultivar and environment. Therefore, this research aimed to evaluate the response of biometric characters of sunflower cv. Embrapa 122-V2000 under N doses. The experiment was carried out in a randomized block design with five treatments (0, 40, 80, 120 and 160 kg N ha-1) and four blocks. All characters were influenced (p<0.05) by N doses, fitting to the quadratic model. The maximum values of plant height (1.68 m), stem diameter (22.71 mm), leaf area (423.41 cm2), capitulum diameter (15.22 cm), dry biomass yield (6,075.13 kg DM ha-1) and grains (2,982.89 kg ha-1), N use efficiency from biomass (80.3 kg kg-1) and grains (43.27 kg kg-1) close to 90 kg N ha-1, this dose being recommended for the edaphoclimatic conditions of the Agreste Meridional Region of Pernambuco, Brazil.
Asymmetric retinal direction tuning predicts optokinetic eye movements across stimulus conditions
Authors: Harris Scott C , Dunn Felice A
Published: March 2023

Across species, the optokinetic reflex (OKR) stabilizes vision during self-motion. OKR occurs when ON direction-selective retinal ganglion cells (oDSGCs) detect slow, global image motion on the retina. How oDSGC activity is integrated centrally to generate behavior remains unknown. Here, we discover mechanisms that contribute to motion encoding in vertically tuned oDSGCs and leverage these findings to empirically define signal transformation between retinal output and vertical OKR behavior. We demonstrate that motion encoding in vertically tuned oDSGCs is contrast-sensitive and asymmetric for oDSGC types that prefer opposite directions. These phenomena arise from the interplay between spike threshold nonlinearities and differences in synaptic input weights, including shifts in the balance of excitation and inhibition. In behaving mice, these neurophysiological observations, along with a central subtraction of oDSGC outputs, accurately predict the trajectories of vertical OKR across stimulus conditions. Thus, asymmetric tuning across competing sensory channels can critically shape behavior.
Lonafarnib improves cardiovascular function and survival in a mouse model of Hutchinson-Gilford progeria syndrome
Authors: Murtada Sae-Il , Mikush Nicole , Wang Mo , Ren Pengwei , Kawamura Yuki , Ramachandra Abhay B , Li David S , Braddock Demetrios T , Tellides George , Gordon Leslie B , Humphrey Jay D
Published: March 2023

Clinical trials have demonstrated that lonafarnib, a farnesyltransferase inhibitor, extends the lifespan in patients afflicted by Hutchinson-Gilford progeria syndrome, a devastating condition that accelerates many characteristics of aging and results in premature death due to cardiovascular sequelae. The US Food and Drug Administration approved Zokinvy (lonafarnib) in November 2020 for treating these patients, yet a detailed examination of drug-associated effects on cardiovascular structure, properties, and function has remained wanting. In this paper, we report encouraging outcomes of daily post-weaning treatment with lonafarnib on the composition and biomechanical phenotype of elastic and muscular arteries as well as associated cardiac function in a well-accepted mouse model of progeria that exhibits severe perimorbid cardiovascular disease. Lonafarnib resulted in 100% survival of the treated progeria mice to the study end-point (time of 50% survival of untreated mice), with associated improvements in arterial structure and function working together to significantly reduce pulse wave velocity and improve left ventricular diastolic function. By contrast, neither treatment with the mTOR inhibitor rapamycin alone nor dual treatment with lonafarnib plus rapamycin improved outcomes over that achieved with lonafarnib monotherapy.
Concurrent remodelling of nucleolar 60S subunit precursors by the Rea1 ATPase and Spb4 RNA helicase
Authors: Mitterer Valentin , Thoms Matthias , Buschauer Robert , Berninghausen Otto , Hurt Ed , Beckmann Roland
Published: March 2023

Biogenesis intermediates of nucleolar ribosomal 60S precursor particles undergo a number of structural maturation steps before they transit to the nucleoplasm and are finally exported into the cytoplasm. The AAA+-ATPase Rea1 participates in the nucleolar exit by releasing the Ytm1–Erb1 heterodimer from the evolving pre-60S particle. Here, we show that the DEAD-box RNA helicase Spb4 with its interacting partner Rrp17 is further integrated into this maturation event. Spb4 binds to a specific class of late nucleolar pre-60S intermediates, whose cryo-EM structure revealed how its helicase activity facilitates melting and restructuring of 25S rRNA helices H62 and H63/H63a prior to Ytm1–Erb1 release. In vitro maturation of such Spb4-enriched pre-60S particles, incubated with purified Rea1 and its associated pentameric Rix1-complex in the presence of ATP, combined with cryo-EM analysis depicted the details of the Rea1-dependent large-scale pre-ribosomal remodeling. Our structural insights unveil how the Rea1 ATPase and Spb4 helicase remodel late nucleolar pre-60S particles by rRNA restructuring and dismantling of a network of several ribosomal assembly factors.
A local cost simulation-based algorithm to solve distributed constraint optimization problems
Authors: Shi Meifeng , Liang Feipeng , Chen Yuan , He Ying
Published: March 2023

As an important incomplete algorithm for solving Distributed Constraint Optimization Problems (DCOPs), local search algorithms exhibit the advantages of flexibility, high efficiency and high fault tolerance. However, the significant historical values of agents that affect the local cost and global cost are never taken into in existing incomplete algorithms. In this article, a novel Local Cost Simulation-based Algorithm named LCS is presented to exploit the potential of historical values of agents to further enhance the exploration ability of the local search algorithm. In LCS, the Exponential Weighted Moving Average (EWMA) is introduced to simulate the local cost to generate the selection probability of each value. Moreover, populations are constructed for each agent to increase the times of being selected inferior solutions by population optimization and information exchange between populations. We theoretically analyze the feasibility of EWMA and the availability of solution quality improvement. In addition, based on our extensive empirical evaluations, we experimentally demonstrate that LCS outperforms state-of-the-art DCOP incomplete algorithms.
Clinical performance of zirconium implants compared to titanium implants: a systematic review and meta-analysis of randomized controlled trials
Authors: Duan Chengchen , Ye Li , Zhang Mengyun , Yang Lei , Li Chunjie , Pan Jian , Wu Yingying , Cao Yubin
Published: March 2023

Purpose

To quantitatively assess and compare the clinical outcomes, including survival rate, success rate, and peri-implant indices of titanium and zirconium implants in randomized controlled trials.

Methods

The electronic databases searched included the Cochrane Central Register of Controlled Trials (CENTRAL), Medline via Ovid, EMBASE, and Web of Science. Randomized controlled trials (RCTs) that reported the effects of zirconium implants on primary outcomes, such as survival rate, success rate, marginal bone loss (MBL), and probing pocket depth (PPD), compared to titanium implants were included in this review. Two reviewers independently screened and selected the records, assessed their quality, and extracted the data from the included studies.

Results

A total of four studies from six publications reviewed were included. Two of the comparative studies were assessed at minimal risk of bias. Zirconium implants may have a lower survival rate (risk ratio (RR) = 0.91, CI [0.82–1.02], P = 0.100, I2 = 0%) and a significantly lower success rate than titanium implants (RR = 0.87, CI [0.78–0.98], P = 0.030, I2 = 0%). In addition, there was no difference between the titanium and zirconium implants in terms of MBL, PPD, bleeding on probing (BOP), plaque index (PI), and pink esthetic score (PES) (for MBL, MD = 0.25, CI [0.02–0.49], P = 0.033, I2 = 0%; for PPD, MD = −0.07, CI [−0.19–0.05], P = 0.250, I2 = 31%).

Conclusion

Zirconium implants may have higher failure rates due to their mechanical weakness. Zirconium implants should be strictly assessed before they enter the market. Further studies are required to confirm these findings.
Roles of cuproptosis-related gene DLAT in various cancers: a bioinformatic analysis and preliminary verification on pro-survival autophagy
Authors: Yang Qinjing , Zeng Shuangshuang , Liu Wei
Published: March 2023

Background

Studies have shown that the expressions and working mechanisms of Dihydrolipoamide S-acetyltransferase (DLAT) in different cancers vary. It is necessary to analyze the expressions and regulatory roles of DLAT in tumors systematically.

Methods

Online public-platform literature on the relationships between DLAT expression levels and tumor prognosis, methylation status, genetic alteration, drug sensitivity, and immune infiltration has been reviewed. The literature includes such documents as The Cancer Genome Atlas (TCGA), Human Protein Atlas (HPA), Tumor Immune Estimation Resource 2.0 (TIMER2.0), Gene Expression Profiling Interactive Analysis 2 (GEPIA2) and Receiver Operating Characteristic plotter (ROC plotter). The molecular mechanisms of DLAT were explored with the Gene Set Enrichment Analysis (GSEA). The relationship between down-regulated DLAT and autophagy in two liver hepatocellular carcinoma (LIHC) cell lines was confirmed with the western blot method, colony formation assay, and transmission electron microscopy. Tissue microarrays were validated through the immunohistochemical staining of DLAT.

Results

DLAT is upregulated in the LIHC, lung adenocarcinoma (LUAD), lung squamous cell carcinoma (LUSC), and stomach adenocarcinoma (STAD) tumors but is down-regulated in the head and neck squamous cell carcinoma (HNSC) and kidney renal clear cell carcinoma (KIRC) tumors in comparison with normal tissues. For LIHC patients treated with 5-Fluorouracil and Lenvatinib, the DLAT levels of those in the drug-resistant group are significantly high. In LIHC cells, autophagy will be inhibited, and cell death will be induced when DLAT breaks down. Moreover, there exist positive correlations between DLAT expression levels and infiltration of B cells, DC cells, Tregs, and CD8+ T cells in kidney chromophobe (KICH), breast invasive carcinoma (BRCA), prostate adenocarcinoma (PRAD), LIHC and HPV+ HNSC. In LIHC, markers of Tregs are positively correlated with DLAT. Compared with those of normal tissues, the staining intensity of DLAT and the amount of Tregs marker CD49d in LIHC increase.

Conclusions

Through this study, the expressions of DLAT in various cancer types can be understood comprehensively. It suggests that DLAT may be a prognostic marker for LIHC, LUAD, LUSC, STAD and KIRC. A high DLAT expression in LIHC may promote tumorigenesis by stimulating autophagy and inhibiting anti-tumor immunity.
Consumer Willingness to Pay (WTP) for Pesticide-Free Vegetables in Palakkad District of Kerala, India
Authors: Koulath B. , Lazarus T. Paul , Thasnimol F. , Nilamudeen Malini , Gopinath Pratheesh P.
Published: March 2023

Aims: To find the Willingness To Pay (WTP) for pesticide-free vegetables by the consumers of Palakkad district in Kerala and the factors influencing the decision.

Place and Duration of Study: The study was conducted in the Palakkad district of Kerala, between March 2022 and December 2022.

Methodology: A sample of 80 consumers spread across the district was randomly selected. The factors influencing the WTP behaviour of the consumers were analysed using a logistic regression model with WTP as the dependent variable and annual income, awareness regarding the presence of pesticide residues, education, food habit, and type of market as exogenous variables.

Results: Out of 80 respondents, 54 of them (67.50 %) expressed their WTP for pesticide-free vegetables. The logit model analysis indicated the annual income of the consumers, education level and awareness of the respondents regarding the presence of pesticide residues were significantly influencing the WTP decision.

Conclusion: The positive responses from consumers towards pesticide-free vegetables could be used as a driving force for farmers to produce and market the same in the study area if they ensure proper marketing focused on awareness promoting programmes on pesticide residues and by establishing the authenticity of the produce's origin.
Constraints and Suggestions of Beneficiary and Non-beneficiary of Farmers towards Pradhan Mantri Fasal Bima Yojana in Kolar District of Karnataka
Authors: Jiragal Imrankhan , Ganesamoorthi S. , Mohankumar T.  L. , Narayanswamy C.
Published: March 2023

India is one of the most climate-prone countries in the world. In the last decade, India has suffered crop losses almost every year either due to floods or drought or frost/extreme temperatures. Agriculture is the mainstay of the rural economy in India and is largely carried out by small and marginal farmers who have poor access to credit, high dependence on rainfall and majority of whom practice subsistence farming. Despite the efforts to revise the insurance scheme features under PMFBY, there are reported issues on enrollment, claim and settlement and even discontinuity. Hence it is essential to analyze the constraints and suggestions of beneficiaries and non-beneficiaries of PMFBY scheme. Hence, the study was conducted in Kolar district of Karnataka state during the year 2021-2022. All the five taluks of Kolar district were selected for the study. From each of the taluk 30 PMFBY beneficiaries and 10 non – beneficiaries were identified for the collection of data by using a simple random sampling method. Thus, the total sample was consisted of 150 beneficiaries and 50 non – beneficiaries. The results revealed that the constraints faced by the beneficiary with respect to availing benefits from PMFBY were, ‘delay in getting the claims under PMFBY’, ‘inadequate compensation under PMFBY’, ‘officials bias in loss assessment making’ and ‘insurance company do not give any reason about why eligible farmers did not receive insurance amount’ were accorded I, II and III ranks, respectively. When it comes to PMFBY non-beneficiaries, were not availing benefits of the scheme due to: ‘lack of documents in the name of the cultivar’ (I rank), ‘lack of awareness about the PMFBY’ (II rank) and ‘requires multiple visit to the department from enrollment to claim’ (III rank). Major suggestions expressed by the beneficiaries for improving PMFBY scheme are: ‘strict measures to timely payment of insurance amount’, ‘reduction on premium amount for horticulture crops’ and ‘claim disbursement before starting of the next season’ were accorded I, II and III ranks, respectively. In respect to suggestion’s expressed by non-beneficiaries for improving PMFBY scheme were: ‘creating awareness about PMFBY scheme’ (I rank), ‘creating facilitation on PMFBY scheme by giving training to the farmers’ (II rank) and ‘submission of appropriate documents to agriculture department’ (III rank).
Productivity, White Rust and Alternaria Blight of Indian Mustard Influenced by Chemical Fungicide Seed Treatment under Humid Southeastern Agro-climatic Zone of Rajasthan, India
Authors: Gupta Geetesh , Gauttam Surbhi , Meena Santosh Kr. , Nagar Rohitashv , Omprakash  , Dogra Prerna
Published: March 2023

The purpose of this study was to evaluate the effect of different chemical fungicides application as seed treatment on growth, plant attributes and grain yields and incidence of diseases of Indian mustard. The field experiments was carried out in a randomized block design with three replications, consisting of 13 treatments namely no soaking control, water soaking, 1% KCl, 1% K2SO4, 1% CaCl2, 1% NaCl, carbendazim 50% WP, mancozeb M-45, KCl + mancozeb M-45, K2SO4 + mancozeb M-45, CaCl2 + mancozeb M-45, NaCl + mancozeb M-45, carbendazim 50% WP + mancozeb M-45. The result revealed that considerably maximum growth attributes (plant height, dry weight/plant, branches/plant, crop growth rate and relative growth rate), plant attributes (siliqua/plant, seeds/siliqua and test weight) and yields (seed, stover and biological) of Indian mustard observed when seeds treated with carbendazim 50% WP + mancozeb M-45 which were significant comparing with the rest of the treatments while it remained at par with K2SO4 + mancozeb M-45, KCl + mancozeb M-45 and mancozeb M-45. Seed treated with carbendazim 50% WP + mancozeb M-45 presented an increment of 111.96 and 95.67% in seed yield, 35.08 and 34.28% in stover yield and 48.72 and 45.8% in biological yield of crop as against to the no soaking control and water soaked treatment, respectively. In respect to percentage of disease incidence, maximum severity of white rust disease and alternaria blight diseases were observed under no soaking control and water soaked treatment. Minimum severity of white rust and alternaria blight diseases were recorded when seeds treated with carbendazim 50% WP + mancozeb M-45. According to our results, carbendazim 50% WP + mancozeb M-45 is the recommended treatment for seed before sowing that led to reducing white rust of leaf and alternaria blight diseases and enhancing the yields of crop with significant increase.