bluuebunny/crossref_metadata_2025 huggingface dataset:
Inorganic Powders Prepared from Fish Scales
Authors: Safronova Tatiana V. , Vorobyov Viktor I. , Kildeeva Natalia R. , Shatalova Tatiana B. , Toshev Otabek U. , Filippov Yaroslav Yu. , Dmitrienko Artem O. , Gavlina Olga Т. , Chernega Olga P. , Nizhnikova Elena V. , Akhmedov Marat M. , Lysenko Konstantin A.
Published: July 2022

Mixture of abramis brama (freshwater bream), carassius carassius (crucian carp), and sander lucioperca (pike perch) scales was used for the preparation of fish scale powder containing about 26.5 wt. % of removed when heating components preferably of organic nature, and 63.5 wt. % of mineral components. Fish scale powder enriched with inorganic components was prepared from washed, dried, and ground fish scale mixture using vibration sieving. Inorganic powders consisting of hydroxyapatite and magnesium whitlockite were obtained via heat treatment of this fish scale powder at 800-1000 oC. Particles of these inorganic powders consisted of sintered grains with dimensions less than 100 nm after heat treatment at 800 oC, less than 200 nm after heat treatment at 900 oC, and 100-500 nm after heat treatment at 1000 oC. Fish scale powder enriched with inorganic components as well as heat-treated inorganic powders consisting of hydroxyapatite and magnesium whitlockite can be recommended for the production of different materials such as ceramics or composites.
Uterus transplantation – worldwide experience
Authors:   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Bayanova S.N. , Aleksandrov L.S. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Ishchenko A.I. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Pletnikov M.V. ,   University at Buffalo, Buffalo, New York, USA, Nikonov A.P. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Ishchenko A.A. , Ishchenko A.A. ,   Medical and Rehabilitation Center, Ministry of Health of the Russian Federation, Moscow, Russian Federation, Bokarev M.I. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Zholobova M.N. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Berishvili M.V. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Budnikova K.A. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Proklova G.F. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation
Published: July 2022

The aim of this research was to analyze the literature on uterus transplantation. The features of the preoperative preparation were presented: recipient and donor selection, surgical aspects of uterus transplantation, postoperative complications and rehabilitation period management, choice of immunosuppressive medications. Special attention was paid to the restoration of fertility and reproductive function in uterus recipients. The results of uterus transplantation from a living donor and a deceased donor in different countries of the world – Germany, USA, Brazil, China were studied. The study shows that although the number of uterus transplants has reached 52 by 2021, this procedure is still not routine and is experimental. Key words: infertility, Mayer-Rokitansky-Küster-Hauser syndrome, uterus transplantation
Role of ultrasound in evaluating the effectiveness of treatment of patients with pelvic organ prolapse and urinary incontinence
Authors:   Pirogov Russian National Research Medical University, Moscow, Russian Federation, Evseev A.A. , Krasnova I.A. ,   Pirogov Russian National Research Medical University, Moscow, Russian Federation, Breusenko V.G. ,   Pirogov Russian National Research Medical University, Moscow, Russian Federation, Aksenova V.B. ,   Pirogov Russian National Research Medical University, Moscow, Russian Federation, Nakryzhskaya M.G. ,   City Clinical Hospital No 17, Moscow, Russian Federation, Surkova E.S. ,   Pirogov Russian National Research Medical University, Moscow, Russian Federation
Published: July 2022

Objective. To analyze the results of pelvic ultrasound before and after the installation of mesh implants to increase the effectiveness of treatment of pelvic organ prolapse (POP) and urinary incontinence. Patients and methods. The study included 96 patients aged 37 to 73 years with a second- and third-degree POP who underwent reconstructive surgery of POP with the installation of mesh implants. In addition to POP, the majority of patients (71.9%) had some form of incontinence during the perioperative period. In 4.2% of patients, incontinence was latent and manifested itself only in the conditions of pelvic organ displacement. Ultrasound markers of incontinence were assessed in the postoperative period: α-angle – between the longitudinal axis of the urethra and the vertical axis of the body, β-angle – between the longitudinal axis of the urethra and the posterior bladder wall. Results. According to the results of ultrasound, which was performed on days 3-5 after surgery, the correction of α- and β-angles to normal values was achieved in 100% of cases regardless of the implant type. The assessment of long-term outcomes (6–21 months) showed that complete clinical and ultrasound effects were achieved in 92.7%, incomplete – in 7.3% of cases. In 7.3% of patients with recurrent POP, ultrasound results revealed abnormalities (abnormal α- and β-angle values) 3-6 months earlier than during the gynecological examination. Stress urinary incontinence (SUI) was relieved in 62.2% of patients. The installation of mesh implants in patients with SUI and overactive bladder (OAB) did not relieve urge incontinence, despite the α-angle values at ultrasound being close to normal. In 4.2% of patients with perioperative latent incontinence, which was diagnosed only by ultrasound, clinical symptoms of incontinence appeared after reconstructive surgery. Conclusion. Ultrasound is an informative method for diagnosing POP and various types of incontinence. Based on objective parameters (α- and β-angle) it is possible to assess the effectiveness of mesh implant installation in peri- and postoperative periods, diagnose hematomas as the cause of dysuric disorders, and identify ultrasound markers of incontinence. Key words: pelvic organ prolapse, stress urinary incontinence, ultrasound examination, surgical treatment
Watching “Wonder Woman”: Reception of an American Film by Youth in Indonesia
Authors: Az-Zahroh Fatimah
Published: July 2022

The popularity of Wonder Woman (2017) movie worldwide is not only reached the western lands but also the eastern countries, including Indonesia. Wonder Woman offers western post-feminist idea which can bring various responses to the audiences in Indonesia. By using descriptive qualitative approach, this research explores how the young audiences in Indonesia take pleasure and make meaning to the element of feminism in the movie. This research finds that Gal Gadot’s Diana performance in the movie offers special spectacle to the audience through her feminine qualities, such as beautiful face, ideal female body, and gentle character, despite being a powerful female hero who also has the quality of courage, strong determination, athleticism, and skill in fighting. The duality of Diana’s character, the femininity and masculinity, is also noted by the audiences as one of the most notably signs which presented feminism in the movie. Although most of the audiences are Muslim and embrace eastern culture, they tend to be more open to the feminist signs in the movie, as they have often been familiarized themselves with western values by frequently watching Hollywood movies.
THE ROLE OF LOCAL ANESTHESIA OF A LAPAROTOMIC WOUND IN THE PREVENTION OF POSTOPERATIVE COMPLICATIONS
Authors:   Krasnoyarsk State Medical University, KONTOREV KONSTANTIN V. , ZDZITOVETSKY DMITRII E. ,   Krasnoyarsk State Medical University, BORISOV ROMAN N. ,   Krasnoyarsk State Medical University
Published: July 2022

Introduction. Wound pain and postoperative complications are a leading problem for patients operated on abdominal organs. In most cases, these two issues are interrelated; that is why their management requires a comprehensive modern approach. Aim. The aim of the study is to evaluate the literature data to identify a causal relationship between wound pain and some complications after abdominal surgeries and to determine the advantages of local anaesthesia of a laparotomic wound, taking into account its additional favourable features. Material and methods. Based on the analysis of Russian and foreign articles, the review presents the structure of the main wound, intra- and extra-abdominal complications after laparotomy, and their producing factors. Moreover, the role of pain during the postoperative period with its multiorgan effect is clearly demonstrated. We considered characteristics of local anaesthetics with their non- standard effects, as well as a comparison of publications regarding the advantages of local anaesthesia in the wound with the systemic administration of parenteral (narcotic and non-narcotic) analgesics, where side effects were also analyzed. Results and discussion. Wound, intra- and extra-abdominal complications after laparotomy are very common today. Pain in the wound area is important in developing each of the complications: it provokes hypodynamia in the postoperative period, develops intestinal paresis, reduces the chest excursion and, as a result, worsens the life quality. All this provokes an increase in intra-abdominal pressure, impaired blood circulation of abdominal organs, wound ischemia in the suture area, lung congestion, which worsens hemodynamics and leads to the systemic consequences. Local anaesthetics are devoid of the well-known side effects of narcotic analgesics and non-steroidal anti-inflammatory drugs. However, they have additional positive local effects. Conclusion. Scientific data analysis has shown that continuous infusion of local anaesthetics into the preperitoneal space of a median laparotomic wound is a promising method for relieving wound pain and preventing postoperative intra- and extra-abdominal complications.
REGIONAL ANALGESIA METHODS FOR TRAUMA PATIENTS
Authors:   Republican Research Center of Emergency Medicine, Tashkent, SHARIPOVA VISOLATKHON H. , ESHBOYEV ABDULKHAKIM T. ,   Republican Research Center of Emergency Medicine, Tashkent, ESHMURODOV DILSHODBEK B. ,   Republican Research Center of Emergency Medicine, Tashkent
Published: July 2022

Introduction. Trauma patients are a special group in which pain control is often a challenge for the anesthetist and resuscitator. In recent years, the role of regional anesthesia in the anesthesia of patients with injuries has been growing and the methods of regional blockades have been improved. Aim. Analysis of scientific medical literature on the pain relief of patients with traumatic injuries. Material and methods. The review and analysis of modern scientific data about the problem of pain relief in patients with trauma in the search databases PubMed and Google Scholar is carried out. Results and discussion. Multimodal anesthesia consisting of ultrasound guided regional anesthesia methods contributes to better pain relief. Good quality pain relief for traumatic injuries reduces the body's stress response to trauma, reduces the opioid consumption and consequently their side effects, significantly reduces the risk of development of chronic pain and improves the quality of life. Therefore, today, regional anesthesia methods are integrated into the protocols of Enhanced Recovery after Surgery (ERAS). This review highlights the literature data on the possibilities of using current regional anesthesia methods for injuries, in particular, combined and multiple traumas. The advantages and disadvantages of various regional blocks in trauma patients are described. Along with the methods of regional anesthesia of the extremities, relatively new methods of fascial blocks which are successfully used for anesthesia of the chest and abdomen are discussed. Conclusion. Personalized multimodal pain therapy aimed at the area of injury using ultrasound navigation is a promising direction in the treatment of pain in trauma patients.
THE ROLE OF POLYMORPHISM OF THE MDR1 GENE FOR THE APPOINTMENT OF NONSTEROIDAL ANTI-INFLAMMATORY DRUGS IN PAIN SYNDROME
Authors:   Tashkent State Dental Institute, ABDASHIMOV ZAFAR B.
Published: July 2022

Introduction. One of the key roles in the excretion of a number of drugs, in particular nonsteroidal anti- inflammatory drugs, has a transport protein glycoprotein P, encoded by the MDR1 gene. In this connection, the influence of genetic polymorphism of glycoprotein P on the pharmacokinetics of these drugs contributes to the prediction of clinical consequences. Aim. The aim of the current study was to study the associations of polymorphic markers C1236T and C3435T of the MDR1 gene encoding glycoprotein P with the development of undesirable drug reactions in patients with pain syndrome. Material and methods. The study included 69 patients with pain syndrome and were divided into 2 groups depending on the presence of adverse drug reactions: NLR+ - 20 patients and NLR - - 49 patients with pain syndrome. The association of the polymorphic marker C3435T of the MDR1 gene was also studied among 22 patients with adverse drug reactions (ADR+) and 47 patients with pain syndrome without the presence of adverse drug reactions (ADR-). Molecular genetic studies were carried out on the basis of the Laboratory of medical genetics of NIIG and the PC of the Ministry of Health of the Republic of Uzbekistan. Results and discussion. During the genotyping, it was found that the occurrence of alleles and genotypes of the polymorphic marker C3435T of the MDR1 gene had significantly significant differences among the patients of the examined groups, depending on adverse drug reactions. Conclusion. The association of the polymorphic marker C3435T of the MDR1 gene with the development of undesirable drug reactions in pain syndrome, the TT genotype and the T allele may be genetic risk factors (OR=4.0 and 8.25; 95% CI 1.78-9.09 and 2.56-26.57, respectively) predisposing to the development of undesirable drug reactions in patients with pain syndrome. Therefore, further study is necessary in order to carry out genotyping of the polymorphic marker C3435T of the MDR1 gene to increase the effectiveness and safety of therapy of nonsteroidal anti-inflammatory drugs.
HYPERURICEMIA: CLINICAL CONSEQUENCES, CARDIOVASCULAR RISK, MODERN APPROACH TO THERAPY
Authors:   Kazan State Medical University, AMIROV NAIL B. , NAUMOVA ASEL YA. ,   Kazan State Medical University, FATYKHOV RENAT G. ,   Medical Care unit of the Ministry of Internal Affairs of Russia in the Republic of Tatarstan, AMIROVA RENATA N. ,   Кazan branch of SOGAZ JSC
Published: July 2022

Introduction. In recent decades, increased attention has been paid to hyperuricemia due to the widespread prevalence of this pathology in the population (16.8%), the presence of a connection with the risk of developing cardiovascular diseases, as well as the variety of its clinical consequences. Aim. A review of current data on the causes of hyperuricemia, clinical aspects, the effect of hyperuricemia on cardiovascular risk, and the current view of therapy, including asymptomatic hyperuricemia. Material and methods. The review carried out topical medical publications in foreign and domestic literature on this issue, accumulated at the present time. Results and discussion. An increase in uric acid level can occur as a result of inaccuracies in the diet, taking certain medications, impaired excretion of uric acid due to impaired renal function and other reasons. Hyperuricemia is the main cause of gout, which can manifest itself as acute gouty arthritis, chronic topical arthritis, urate nephropathy, and other diseases. Modern research shows that an increase in serum uric acid concentration is associated with an increased cardiovascular risk. Acting as an independent predictor of arterial hypertension, coronary heart disease, chronic heart failure, chronic kidney disease. Treatment with xanthine oxidase inhibitors (allopurinol, febuxostat) can affect hyperuricemia, gout, and various forms of ischemic and vascular damage. As evidence of the efficacy of urate-lowering therapy remains controversial, these drugs are not currently indicated for routine prophylactic treatment in patients without gout symptoms. In 2018, specialists in the field of hyperuricemia proposed an algorithm for the management of patients with asymptomatic hyperuricemia. However, the algorithm is not recommended for everyday practice due to further research's need to verify it. Conclusion. Classic manifestations of hyperuricemia such as gout and kidney damage remain the main indications for urate-lowering therapy. At the same time, the increased cardiovascular risk in hyperuricemia, proven by numerous studies, requires special attention in treating patients with comorbid pathology. Diet and lifestyle changes remain an integral part of therapy. The final decision on the need for pharmacological treatment of patients with asymptomatic hyperuricemia with xanthine oxidase inhibitors is made individually. The development of algorithms and indications for the appointment of urate-lowering therapy continues. Recommendations for drug therapy for hyperuricemia are only possible after large, double-blind, placebo-controlled, randomized trials.
APPLICATION OF ORGANIC COMPOUNDS IN THERAPEUTIC PRACTICE FOR LIVER FUNCTION DISTURBANCES
Authors:   Siberian State Medical University, Tomsk, SOROKINA TATIANA V. , DAVYDOVA VALENTINA V. ,   Siberian State Medical University, Tomsk, KOLESNIK NATALIA Yu. ,   Siberian State Medical University, Tomsk, BOLVANTSEVA ALYONA I. ,   Siberian State Medical University, Tomsk, SAMOYLOVA YULIA G. ,   Siberian State Medical University, Tomsk, OLEYNIK OXANA A. ,   Siberian State Medical University, Tomsk, TOLMACHEV IVAN V. ,   Siberian State Medical University, Tomsk
Published: July 2022

Introduction. The nonspecificity of the clinical manifestations of the initial stage of non-alcoholic fatty liver disease (NAFLD) - the stage of steatosis, is the reason for the untimely correction and progression of this disease. Aim. The aim of the study was to conduct a randomized open comparative study to determine the effectiveness of the use of the food supplement FanDetox as a source of organic compounds in liver function disorders. Material and methods. This study was a single-center randomized open one and included the study of the possibility of using the herbal product FanDetox in the complex therapy of NAFLD in patients aged 18 to 75 years with a verified diagnosis of obesity and the presence of signs of steatohepatosis, against the background of basic therapy with Carsil Forte. The study was conducted with the involvement of 68 people matched by sex and age, 34 of whom made up the main observation group, whose participants took the study product 1 sachet 2 times a day after meals, in the form of a suspension obtained after mixing the powder in 100 ml of water. The rest 34 patients made up the comparison group. Carsil Forte was chosen as a background drug for both groups. The duration of therapy for each study participant was 3 months. The follow-up process included patient visits with a detailed medical history, therapeutic examination, and laboratory and instrumental examinations. Statistical analysis was carried out using the IBM SPSS Statistics 23 program. Results and discussion. As a result, an improvement in the subjective well-being of patients, a decrease in the echoscopic manifestations of fatty hepatosis, a decrease in the longitudinal size of the liver, a decrease in the manifestations of the cytolysis syndrome and bilirubin levels, as well as a significant positive dynamics of the lipid spectrum in the blood of patients who received complex therapy, including the use of the FanDetox biologically active additive, compared with the comparison group undergoing therapy with the background drug Carsil Forte, were shown. Conclusion. It has been established that taking the food supplement FanDetox helps to reduce the manifestations of fatty hepatosis, reduce the longitudinal size of the liver, blood biochemistry indicators and the general well-being of patients.
FORMING GRAMMATICAL COMPETENCE WHILE TEACHING PROFESSIONALLY-ORIENTED FOREIGN LANGUAGE IN NON-LINGUISTIC UNIVERSITIES
Authors: Berkutova Tetiana , Vrakina Viktoriia , Sadkovska Valeriia
Published: July 2022

The article deals with teaching grammar in Ukrainian education community. Students start learning grammar at secondary, sometimes even at primary schools, and continue acquiring it while studying at institutions of higher education. However, qualitative progress in grammar usage while writing and speaking English is rarely seen. One possible explanation is that there is a widely adopted approach in Ukrainian education system according to which the formation of grammatical competence goes through a number of fixed steps from grammar knowledge to speech practice. It is assumed that detailed and thorough knowledge of rules of English grammar and their difference from grammar rules of the Ukrainian language contributes to better understanding of peculiar features of the English language and further it positively influences the acquisition of all language skills and abilities. Unfortunately, considering the real situation of teaching English at Ukrainian universities under conditions of insufficient class-room academic hours, such an approach does not bring desired results. Communicative approach of teaching foreign languages and competencies that are to be developed demands a different approach to teaching grammar that is a holistic approach.
DESIGNING SPACE IN MARTYROLOGY FACILITIES, CEMETERY AND CREMATORY IN EUROPE
Authors:   Politechnika Warszawska Wydział Architektury Katedra Projektowania Urbanistycznego i Krajobrazu Wiejskiego, Purski Michał
Published: July 2022

The article presents research on the conscious shaping of the space of martyrology objects, cemeteries and crematoriums in Europe. In his research, the author focused on the elements of architectural and urban composition, as well as spatial treatments experienced by users on three levels: pre-narrative, proton-narrative and procedural narratives of the unconscious (Dimaggio, Semerari, 2001, 14: 1-23), as based solely on the user's sensual experience. Selected elements influencing the user were divided into three categories: inducing action, focusing attention or inducing a reaction, and building awareness of space.
Education Pillar as a Community-Based Prevention Stunting During Covid-19 Pandemic
Authors: Simbolon Demsa , Yusmidiarti  , Ludji Ina Debora Ratu
Published: July 2022

The high prevalence of stunting and poor environmental health conditions at Bengkulu and Kupang City, baseline the need for assistance to families to provide education on Community-Led Total Sanitation (CLTS). Through the implementation of the CLTS module science and technology, the purpose is to foster and empower CLTS cadre groups as family companions to educate about the 5 pillars of CLTS by increasing family knowledge, attitudes, and actions in preventing and overcoming stunting. The target audience is 40 families in Bengkulu and 40 families in Kupang City. Community Service activities were preceded by socialization with local governments and health workers, followed by training and coaching of cadres, and family assistance activities, by providing CLTS sanitation education for 4 months through home visits, assessed once a month. The results show that cadre training is effective in increasing the knowledge and attitudes of cadres. Family assistance activities are effective in increasing family knowledge, attitudes, and actions about CLTS in stunting prevention. Environmental health officers together with cadres need to improve programmed triggering activities, monitoring, and evaluation, as well as assistance for the community and local government advocacy to support the success of the CLTS implementation.
How the Learning Environment Influences Bullying: The Case of Two Universities in Ghana
Authors: Tay Emmanuel Mensah Kormla , Zamore Stephen
Published: July 2022

Organisational climates determine the experiences, well-being, and output of people. In response to a growing concern about bullying and victimisation at universities, this study examined students’ perception of the university learning environment concerning their experience of various negative behaviours and victimisation at two public universities in Ghana. The study is a cross-sectional survey of 751 respondents. Confirmatory Factor Analysis (CFA) and regression analysis indicate how perceptions of the universities’ learning environment are related to students’ experiences. With an inverse relationship between students’ perception of the learning environment and their experience of various negative behaviours and victimisation, the study suggests that awareness of anti-bullying rules, which are strictly, fairly, and consistently enforced through participatory democratic principles, will be essential to ensure a positive psychosocial learning environment.
Spanish Validation of The Experiences in Close Relationships-Relationship Structures Questionnaire for Pre-adolescents
Authors: Larrucea-Iruretagoyena Maite , Orue Izaskun
Published: July 2022

This study aimed to validate the Spanish version of the Experiences in Close Relationships–Relationship Structures questionnaire (ECR–RS; Fraley et al., 2011). This instrument measures the two-dimensional structure of attachment (anxiety and avoidance) in different relational domains (mother, father, and friends). The sample was composed of 795 pre-adolescents (49.1% girls), aged 9–14 (M=12.86; SD=1.28), who were randomly selected from seven Biscayan schools. The participants completed the measures of attachment, prosocial behavior, emotional and behavioral problems, and difficulties in emotional regulation. The confirmatory factor analysis indicated that the Spanish adaptation of the ECR–RS supported the original two-factor structure and was invariant across genders. Both attachment dimensions were positively associated with emotional and behavioral problems, and difficulties in emotional regulation, and were negatively correlated with prosocial behavior. Gender differences were found in friends, mother, and global measures, in which boys scored higher than girls in anxiety and girls higher than boys in avoidance. This study demonstrated that the Spanish adaptation of the ECR–RS for pre-adolescents is a reliable and valid instrument to measure anxiety and avoidance attachment in different relational domains
Arsip Audiovisual sebagai Sumber Sejarah
Authors: Pianto Heru Arif
Published: July 2022

Pada kehidupan sehari-hari kita serin sekali membaca suatu cerita sejarah yang hanya mebicarakan masalah-masalah besar dan berbasis kekuasaan saja. Dengan demikian maka sangatlah tidak mengherankan apabila sejarawan mudah mengarsipkan sumber sejarahnya. Akan tetapi  dalam kenyataan sehari-hari sejarawan dalam menggunakan sumber sejarah hanya berupa buku atau dokumen saja. Mereka seakan-akan lupa bahwa visual atau gambar juga dapat digunakan sebagai sumber sejarah. Media film contohnya, media tersebut dapat digunakan sebagai sumber sejarah yang kredibel dan dapat dipertanggungjawabkan keauntetikannya.

Luaran hasil penelitian ini diharapkan  (1) menjadi artikel ilmiah yang dimuat dalam jurnal yang ber ISSN, (2) Publikasi hasil penelitian melalui seminar nasional yang diikuti oleh berbagai dosen dan mahasiswa pada perguruan tinggi, (3) Menjadi sebuah acuan untuk penyusunan materi sejarah lokal.

Metode penelitian yang digunakan dalam penyusunan karya ilmiah ini adalah metode penelitian sejarah, dengan cara merekonstruksi masa lampau melalui proses pengujian dan analisis secara kritis terhadap rekaman dan peninggalan masa lampau. Secara garis besar penelitian sejarah terbagi menjadi empat tahapan yaitu, heuristik, kritik, interpretasi dan historiografi.
New impressive vision solitary wave solutions of the Bogoyavlenskii equation in comparison with its numerical solutions
Authors: Zahran Emad H.M. , Bekir Ahmet
Published: July 2022

In this article, we will establish new impressive vision for the solitary solutions of Bogoyavlenskii-equation (BE) that represent the (2 + 1)-dimensional interaction of a Riemann wave propagation along definite axis along wave on the normal to it. A comparison between the achieved results from the point of view of three different mathematical analysis tool methods according to its personal profile name have been constructed. The three methods that included for this target are the Paul-Painlevé approach method (PPAM), the Ricatti-Bernoulli Sub-ODE method (RBSODM) and the third one is the variational iteration method (VIM). The three suggested methods have been implemented at the same time and parallel to detecting different new visions for the solitary wave solutions of proposed model.
A Review On Sram Memory Design Using Finfet Technology
Authors: Lakshmi Thota. Venkata , Kamaraju Madduraju
Published: July 2022

An innovative technology named FinFET (Fin Field Effect Transistor) has been developed to offer better transistor circuit design and to balance the necessity of superior storage system (SS). As gate loses control over the channel, CMOS devices face some major issues like increase in manufacturing cost, less reliability and yield, increase of ON current, short channel effects (SCEs), increase in leakage currents etc. However, the memory must have less power dissipation, short access time and low leakage current. The traditional design of SRAM (Static RAM) using CMOS technology represents severe performance degradation due to its higher power dissipation and leakage current. Thus, a Nano-scaled device named FinFET is introduced for designing SRAM since it has three dimensional (3D) design of the gate. FinFET has been used to improve the overall performance, which includes efficiency, power, and area. Moreover, FinFET has been chosen as a transistor of choice because it is not affected by SCEs. In this work, we have reviewed various FinFET based SRAM cells, performance metrics and the comparison over different technologies.
Circular RNA circMAN1A2 promotes ovarian cancer progression through the microRNA- 135a-3p/IL1RAP/pTAK1 pathway
Authors: Li Bo , Hu Chuancui , Zhao Da , Nie Mingchao , Wang Xiaoli
Published: July 2022

Background
Ovarian cancer (OC) is the most lethal malignancy in women owing to its diagnosis only at the advanced stage. Elucidation of its molecular pathogenesis could reveal new tumor markers and targets for therapy. Circular RNAs (circRNAs) are stable, conserved, and functional biomolecules that can be used as effective biomarkers for various cancers. In this study, a potential circRNA related to early diagnosis of OC, circMAN1A2, was analyzed.
Methods
Overexpression/knockdown of circMAN1A2 in OC cells was used to decipher its effects on cell proliferation with CCK8, EdU, cell cycle, clone formation and wound healing assay. RNA pull-down, RIP and Dual luciferase assay were used to explain the underlying mechanism of circMAN1A2 regulation of OC cell proliferation. In vivo, the effect of circMAN1A2 in OC was evaluated using nude mouse xenograft experiments.
Results
circMAN1A2 was highly expressed in OC and promoted proliferation, clone formation, and tumorigenicity of OC cells. In addition, we found that circMAN1A2 acts as a sponge for microRNA (miR)-135a-3p; miR-135a-3p directly targets the 3′ untranslated region of IL1RAP in OC cells, thereby regulating the phosphorylation of TAK1, which results in promotion of OC cell growth. Therefore, circMAN1A2 promotes OC cell proliferation by inhibiting the miR-135a-3p/IL1RAP/pTAK1 axis.
Conclusion
circMAN1A2 may be a biomarker for early detection of OC and a target for subsequent therapy.
Cryptomelane Modified Biomass Wastes for Solar Interfacial Evaporation and Stabilization of Cadmium
Authors: Zhang Baoyu , Fan Chenzi , Guo Wei , Zhu Yun
Published: July 2022

In recent years, solar interfacial evaporation has received increasing attention due to its potential applications in power generation, seawater desalination, and wastewater treatment. In this work, after carbonization of two biomass wastes, rice husk and coconut husk, they were modified by hydrothermally synthesized cryptomelane manganese and prepare into a solar interfacial evaporation system to explore their evaporation performance and stabilization performance of cadmium. The results demonstrate that the cryptomelane modified biochar can obtain an evaporation rate of 1.085 kg m− 2 h− 1 and a photothermal conversion efficiency of 77.75% under one sun (1 kW m− 2). Under the condition that the average solar power density is only 465.22W m− 2, the evaporation amount reaches 4.7kg m− 2 within six hours, and the evaporation rate reaches 0.78kg m− 2 h− 1. The two kinds of biomass wastes modified by cryptomelane have enhanced adsorption performance for cadmium, and can be well used for long-term stabilization and recycling of Cd. It could be verified that the cryptomelane modified biochar material is a low-cost, scalable and efficient material for interfacial evaporation and reduce wastewater pollution.
Innovative study in renewable energy source through mixed surfactant system for eco-friendly environment
Authors: Lal Mohan , Gangotri Kajod Mal Mal
Published: July 2022

Actual plan of research work was proposed for systematic investigating in the field of photogalvanic cell (PG cell) for solar energy transformation. It was necessary and proposed to carry out experimental work under the solar parameters. The object of the research work is to enhance the solar energy conversion in to electricity and store through photogalvanic cells. Various parameters were studied in a photogalvanic cell having D-Xylose + MB + Brij-35 + NaLS PGS (photo galvanic system). The open circuit voltage and photopotential were observed 921.00 mV and 698.00 mV respectively for D-Xylose + MB + Brij-35 + NaLS PGS. The maximum photocurrent and short circuit current were observed 311µA and 245.0 µA respectively in D-Xylose + MB + Brij-35 + NaLS PGS. The equilibrium photocurrent and current at power point were observed 243.0 µA and 142.0 µA respectively in D-Xylose + MB + Brij-35 + NaLS PGS. The fill factor and conversion efficiency were observed 0.4521 and 0.6769% respectively in D-Xylose + MB + Brij-35 + NaLS PGS. The impact of solar energy was studied by vary the various parameters in PGS. The D-Xylose + MB + Brij-35 + NaLS PGS performance was found 126.00 minutes in absence of light on illumination of 90.0 minutes. On basis of above obtained values, the mixed surfactants (NaLS + Brij-35) have experimentally proved the efficient system as desired object of research with special reference to enhance electrical out and storage of solar energy.
Analysis of oxidase activity and transcriptomic changes related to cutting propagation of hybrid larch
Authors: Qin Ruofan , Zhao Qingrong , Gu Chenrui , Wang Chen , Zhang Lei , Zhang Hanguo
Published: July 2022

Hybrid larch is the main timber and afforestation tree species in Northeast China. To solve the problem of rooting difficulties in larch cutting propagation, enzyme activity determination and transcriptome sequencing were carried out on the rooting tissues at five timepoints after cutting. POD, PPO and IAAO play important roles in the larch rooting process after cutting. A total of 101.20 Gb of clean data was obtained by transcriptome sequencing, and 43,246 unigenes were obtained after further screening and assembly. Most of the differentially expressed genes identified among the cutting propagation periods were enriched in the plant hormone signal transduction, phenylpropanoid biosynthesis and photosynthesis pathways. A total of eleven genes, including AUX/IAA, NAC, WRKY, AP2/ERF, and LBD, may be related to rooting, while others, such as LBD, NAC, AP2/ERF, and bHLH, may be important in different stages of cutting propagation. As the rooting rate after cutting inhibits the development of larch clone propagation, identifying the genes that regulate rooting could help us to preliminarily understand the molecular mechanism of adventitious root formation and select a better treatment method for cutting propagation.
Doping effects in the alanine-black phosphorene interactions: first principles studies
Authors: Calvario-Coyotl Javier , Gutierrez-Ojeda Sandra Julieta , Rubio-Pereda Pamela , Esteban-Gómez Sandra , Garza Leonardo Morales de la , Hernandez-Cocoletzi Gregorio
Published: July 2022

This work deals with the doping effects in the structural and electronic properties of the alanine adsorption on the black phosphorene layer. Studies are done using ab-initio total energy calculations within the periodic density functional theory (DFT) together with the generalized gradient approximation (GGA) and the pseudopotential method. Van der Waals effect is taken into account in the calculations provided that molecules may be polar. To start studies the alanine is allowed interacting with the pristine phosphorene with results indicating that only weak interactions are manifested. Metallic (aluminum, gallium and boron) atoms as impurities are incorporated in the phosphorene to transform the layer into a more reactive material to enhance the interactions between the molecule and the phosphorene. In fact, this is achieved and as a result the binding energies increase, in such a way that chemisorption is obtained. In this way the most reactive system corresponds to that doped with Al. This is corroborated by the binding energy results. The electronic properties are explored considering the total density of states and the projected density of states. No significant changes are obtained concerning the band gap energies as a consequence of the alanine adsorption. At last, the charge density plots exhibit the covalent bonds manifestations between the molecule and the surface impurity.
GIS-Based Multi-Criteria Analytical Hierarchy Process Modelling for Urban Flood Risk Analysis and Assessment, Accra Metropolis
Authors: Nkonu Raymond Seyeram , Antwi Mary , Amo-Boateng Mark , Dekongmen Benjamin Wullobayi
Published: July 2022

A series of devastating flood events within the Accra Metropolis over the last decades have demonstrated the urgent need for urban resilience. The present work aimed to develop a GIS-based model to analyse and assess floods in the Accra Metropolis. The framework is based on the Multi-Criteria Analytical Hierarchy Process within the GIS platform. Relevant thematic layers including LULC, Elevation, Slope, Soil, and Drainage density were generated within the GIS environment. In the context of objective weight assignments, the AHP algorithm was successfully applied to create flood hazard indices, and then the urban flood risk maps were constructed for 2007, 2010, 2015 and 2020. The findings revealed that areas under high and very high flood risk have increased from 55.163–60.043% over the last decade and a half. A flood inventory map was produced by randomly mapping 256 flood test locations to determine the model's performance. These locations consisted of 128 flooded and 128 non-flooded points extracted from historical flood data, ground truth data and high-resolution satellite imagery. The computed Receiver Operating Characteristic (ROC) curve showed an Area Under the Curve (AUC) value of 0.916, indicating an excellent correlation between the analysed flood risk areas and the ground truth data. Findings from the study will assist decision-makers in formulating medium-long term mitigation measures to reduce flood-related damages and employ proper future land-use planning.
Transparency of clinical practice guideline funding: A cross-sectional analysis of the German AWMF registry
Authors: Napierala Hendrik , Schuster Angela , Gehrke-Beck Sabine , Heintze Christoph
Published: July 2022

Background:While reporting of individual conflicts of interest is formalized, it is currently unclear to what extent the funding is reported in clinical practice guidelines (CPGs). The aim of this study therefore was to explore the quality of reporting on funding in German CPGs.Methods:We searched for available CPGs in the registry of the Association of the Scientific Medical Societies in Germany in July 2020. Information on guideline funding was categorized by two reviewers independently and discrepancies were clarified by discussion with a third reviewer. The editorial independence of the funding body was assessed with the German Instrument for Methodological Guideline Appraisal (DELBI).Results:We analyzed 762 CPGs, 60.6% (462) of these provided interpretable information. Transparency increased with the methodological requirements of the respective guideline tier but only 3.5% (27) of CPGs achieved the highest DELBI score. Funding sources and expenses were dependent of the CPG tier.Conclusion:Funding practices are not communicated transparently in German CPGs. There is no definite picture of exact funding sources, expenses and volumes throughout all guideline tiers. This study aims to foster public discussion and increased transparency of guideline funding to improve the development of and trust in CPGs.
Predicting Ophthalmic Clinic Non-attendance using Machine Learning
Authors: Breeze Finley , Hossain Ruhella , Mayo Michael , McKelvie James
Published: July 2022

Background
Ophthalmic clinic non-attendance in New Zealand is associated with poorer health outcomes, marked inequities and costs NZD$30m per annum. Initiatives to improve attendance typically involve expensive and ineffective brute-force strategies.
Purpose
To develop machine learning models to accurately predict ophthalmic clinic non-attendance.
Methods
Nationwide ophthalmology clinic attendance data was aggregated for analysis. In addition to a single global model, data were stratified by DHB to train regional models. Model weighting was adjusted to account for the highly imbalanced dataset. Repeated ten-fold cross validation was used to ensure that model selection and evaluation metrics were robust. Logistic regression and XGBoost model performance were evaluated on all NZ publicly funded ophthalmology clinics.
Results
Data included 3.1 million clinic appointments with 5.8% non-attendance rate from 2009 to 2018. Appointments from 2018 onwards were used as a test set outside of the cross-validation experiments to simulate prospective evaluation. Across multiple centres, an average model AUROC of 0.76 and AUPRC of 0.16 was achieved on the test data. DHBs with higher non-attendance rates had improved AUPRC. For example, Tairawhiti DHB had 7.8% non-attendance and achieved AUPRC of 0.29.
Conclusion
It is possible to use machine learning algorithms to make clinically useful predictions of clinic non-attendance. The model in the current study is competitive with previously published models of clinic attendance in the literature using fewer input features. This level of discrimination is high enough to be used in advanced scheduling methods and targeted public health interventions.
Training of professional caregivers in the management of psychological and behavioural symptoms of patients suffering from neurocognitive pathologies through virtual reality: Feasibility study, caregiver satisfaction and training effectiveness
Authors: Lenoir Hermine , Pino Maribel , Dacunha Sebastien , Rigaud Anne-Sophie
Published: July 2022

During Alzheimer's disease and related disorders (ADRD), the inability to express one's needs due to cognitive impairments, and loss of self-control abilities, can lead to behavioural disorders which treatment (with medications) can be source of side effects. These issues are avoidable if caregivers are well-trained to verbal and nonverbal (V/NV) communication skills allowing appropriate responds to patients' diminished verbal expressions and non-verbal cues to best meet their needs, avoiding conflictual situations, caregiver burnout and delay in caregiving. However, access to trainings is limited by the constrained financial context, the shortage in health-care professionals, and due to social restrictions imposed by the COVID-19 pandemic. Recent advances in educational technology, particularly virtual reality (VR), may help train caregivers to clinical reasoning in a safe environment with immediate feedback on their achievements. The aim of our study is to develop and assess a VR teaching tool reproducing care scenarios. Immersed in a virtual care environment, 20 professional caregivers will assist to V/NV interactions between a virtual colleague and a patient (played by an actor) through two different scenarios. The trainee will have to identify and criticize inappropriate and more appropriate interactions in each clinical situation. Assessments will be performed to provide learners with personalized and detailed feedback on their achievement, measure their satisfaction with the training tool and feeling of competence. Our hypothesis is that the learner caregiver will acquire skills in non-drug management of disturbing psycho-behavioural symptoms of ADRD, in different care settings, autonomously, safely, without temporal constraints, and at lower cost.Trial Registration This study is registered in the French General Data Protection Regulation registry of Assistance Publique – Hôpitaux de Paris the 05/18/2022 under the N° 2022 0518135339
Fractal Dimension Complexity of Gravitation Fractals in Central Place Theory
Authors: Banaszak Michał , Górnisiewicz Krzysztof , Nijkamp Peter , Ratajczak Waldemar
Published: July 2022

Settlement centers of various types, including cities, produce basins of attraction whose shape can be regular or complexly irregular (from the point of view of geometry). It depends, among others, on the properties of the space surrounding a city. Central Place Theory (CPT), a well-known concept in economic geography and spatial economics, explains the spatial structure inherent in distinct economic orders of urban centers in geographical space. In Christaller’s original formulation the fundamental architecture of CPT is based on a static approach which focuses on the optimal division of space around urban centers, while following pre-specified plausible rules of supplying them with goods from other places. Conducted in the spirit of recent works, this study demonstrates that by introducing a dynamic approach to space and including an equation of motion and space resistance, a dramatic change of the idealized static CPT image occurs. As a result of the interplay of gravitational forces, basins of attraction arise around cities, whose boundaries are fractals. This paper provides a wealth of spatial fractal complex images that question the relevance and validity of traditional CPT.
Spectroscopic Evidence for Superconductivity of Elemental Metal Y under Pressures
Authors: Park Tuson , Cao Ziyu , Jang Harim , Choi Seokmin , Kim Jihyun , Kim Suyoung , Zhang Jian-Bo , Anir Sharbirin , Kim Jeongyong
Published: July 2022

Very high applied pressure induces superconductivity with the transition temperature (Tc) exceeding 19 K in elemental yttrium, but relatively little is known about the nature of that superconductivity. From point-contact spectroscopy (PCS) measurements in a diamond anvil cell (DAC), strong enhancement in the differential conductance is revealed near the zero-biased voltage owing to Andreev reflection, a hallmark of SC phase. Analysis of PCS spectra based on the extended Blonder-Tinkham-Klapwijk (BTK) model indicates two SC gaps at 48.6 GPa, where the large gap ΔL is 3.63 meV and the small gap ΔS is 0.46 meV. When scaled against the reduced temperature, both small and large SC gaps collapse on a single curve that follows the prediction from the BCS theory. The SC gap-to-Tc ratio is 8.2 for the larger gap and the initial slope of the upper critical field is -1.9 T/K, indicating that Y belongs to a family of the strongly coupled BCS superconductors. The successful application of PCS to Y in DAC environments demonstrates its utility for future research on other pressure-induced high-Tc superconductors.