bluuebunny/crossref_metadata_2025 huggingface dataset:
Antioxidant activity and myco-chemical profiling of Campylospora parvula Kuzuha isolated from the roots of Rubus ellipticus
Authors: Pant Prabha , Kumar Parikshit , Sati Suresh Chandra
Published: July 2024

Endophytic fungi are important sources of various bioactive natural compounds. Present work elucidates the antioxidant activity and chemical characterization of Campylospora parvula Kuzuha isolated from the roots of ethno medicinal plant Rubus ellipticus. Antioxidant activities were tested using DPPH, MCA and FRAP assays, total phenolic and flavonoid content by Folin-Ciocalteu and aluminum chloride method, respectively. Chemical profile of ethyl acetate extract was illustrated by using Gas chromatography and mass spectrometry (GC-MS) analysis. The ethyl acetate extract of C. parvula presents IC50, 47.75±3.6 µg/ml for DPPH, 53.36±2.6 µg/ml for MCA and 360.54±8.6 AAE/g dry extract for FRAP assay. GCMS analysis revealed the presence of Octanal, 2-(phenylmethylene)- (16.24%), 1-(4-Iopropylphenyl)-2-methylpropyl acetate (12.91%), Benzoic acid, 2-hydroxy-, phenylmethyl ester (11.85%) as major compounds. Findings of the present study are promising and keenly hopeful for further research on individual compound to assess their potential, especially in the pharmacology sector.
The interplay between exchange and microscopic kurtosis as measured by diffusion MRI with double diffusion encoding: Theory and simulations
Authors: Chakwizira Arthur , Szczepankiewicz Filip , Nilsson Markus
Published: July 2024

Double diffusion encoding (DDE) makes diffusion MRI sensitive to a wide range of microstructural features, and the acquired data can be analysed using different approaches. Correlation tensor imaging (CTI) uses DDE to resolve three components of the diffusional kurtosis: isotropic, anisotropic, and microscopic. The microscopic kurtosis is estimated from the contrast between single diffusion encoding (SDE) and parallel DDE signals at the same b-value. Another approach is multi-Gaussian exchange (MGE), which employs DDE to measure exchange. Sensitivity to exchange is obtained by contrasting SDE and DDE signals at the same b-value. CTI and MGE exploit the same signal contrast to quantify microscopic kurtosis and exchange, and this study investigates the interplay between these two quantities. We perform Monte-Carlo simulations in different geometries with varying levels of exchange and study the behaviour of the parameters from CTI and MGE. We conclude that microscopic kurtosis from CTI is sensitive to the exchange rate. In an attempt to separate microscopic kurtosis from exchange, we propose a heuristic signal representation referred to as µMGE (MGE incorporating microscopic kurtosis) that accounts for both effects, by exploiting the distinct signatures of exchange and microscopic kurtosis with varying mixing time: exchange causes a dependence of the signal on mixing time while microscopic kurtosis does not. We find that applying µMGE to data acquired with multiple mixing times for both parallel and orthogonal DDE allows estimation of exchange as well as all three sources of kurtosis.
Integration of Renewable Energy and Microgrid Systems to Enhance Voltage Quality and Minimize Harmonic Distortion Losses Using Advanced Control Techniques
Authors: Tabassum Saleha , Sandhyakumari G. , V Madhurima , Bharathi M.
Published: July 2024

This study explores integrating renewable energy sources into microgrid systems to improve voltage quality and reduce harmonic distortion losses using an Adaptive Neuro-Fuzzy Inference System (ANFIS) controller. Microgrids with renewables offer enhanced energy reliability and efficiency but face challenges like voltage fluctuations and harmonic distortions. Renewable sources like solar and wind introduce variability, impacting voltage stability and causing harmonic distortions in the grid. The ANFIS controller adapts to these dynamics by dynamically adjusting parameters, leveraging neural network adaptability and fuzzy logic's interpretability to manage nonlinear and uncertain behaviors typical of renewables. The research aims to optimize microgrid performance by mitigating voltage fluctuations and harmonic distortions through ANFIS. By improving operational stability and efficiency, this approach supports effective renewable energy integration into broader grid infrastructures. Through empirical analysis and simulations, the study provides insights into ANFIS's practical application in microgrid management, contributing to sustainable energy solutions and grid resilience.This research underscores the importance of ANFIS controllers in enhancing renewable energy integration within microgrid systems, offering actionable strategies for improving energy sustainability and reliability in modern power networks.
Supramolecular polyrotaxane-based nano-theranostics enable cancer-cell stiffening for enhanced T-cell-mediated anticancer immunotherapy
Authors: Yang Zhen , Luo Haifen , Lv Jingqi , Wen Peiye , Zhang Shan , Ma Wen
Published: July 2024

Despite the tremendous therapeutic promise of activating stimulators of interferon genes (STING) enable to prime robust de novo T-cell responses, biomechanics-mediated immune inhibitory pathways hinder the cytotoxicity of T cells against tumor cells. Blocking cancer cell biomechanics-mediated evasion provides a feasible strategy for augmenting STING activation-mediated anti-tumor therapeutic efficacy. Here, we fabricate a redox-responsive Methyl-β-cyclodextrin (MeβCD)-based supramolecular polyrotaxanes (MSPs), where the amphiphilic diselenide-bridged axle polymer loads MeβCD by the host-guest interaction and end-caping with two near-infrared (NIR) fluorescence probes IR783. The MSPs self-assemble with STING agonists diABZIs into nanoparticles (RDPNs@diABZIs), which enable simultaneous release of MeβCD and diABZIs in the redox tumor microenvironment. After the released diABZIs activate STING on antigen-presenting cells (APCs), de novo T-cell responses are initiated. Meanwhile, the released MeβCD depletes membrane cholesterol to overcome cancer-cell mechanical softness, which enhances the CTL-mediated killing of cancer cells. In the tumor-bearing mouse model, we demonstrate that RDPNs@diABZIs lead to effective tumor regression and generate long-term immunological memory. Furthermore, RDPNs@diABZIs can achieve complete tumor eradication in about 62.5% of mice, and they regained tumor-free survival of at least 2 months.
Dynamic economic dispatch problem in hybrid renewable based power systems using oppositional based chaotic honey badger algorithm
Authors: Mandal Barun , Roy Provas Kumar , Paul Chandan
Published: July 2024

In this work, the chaotic honey badger algorithm (OCHBA) based on oppositional theory is used for the investigation of the wind-solar-electric vehicle (EV)-thermal based dynamic economic dispatch (DED) problem. The co-generation of solar, wind and battery storage units is optimised by the suggested approach. A constrained nonlin-ear optimization problem with discrete and continuous variables that is non-convex on a large scale is used to simulate the DED. A more reliable and efficient DED algorithm is required for direct power system operators’ decision-making. In order to minimise generation costs and simultaneously meet different load needs, DED calculates the amount of electrical power that committed units in a power system will generate. The development, testing and comparison utilising the 10-unit and 15-unit benchmark systems show the viability and efficacy of the suggested approach. Moreover, the results demonstrate the potential of the suggested method as well as its reliability and efficacy in resolving the DED issue for the systems under consideration. The results of the proposed approach methodology is compared with several methods that have been published most recently and the suggested OCHBA approach is used in multiple test systems with complex solution spaces in order to demonstrate its effectiveness and benefits. The suggested approach’s functionality and performance are contrasted with the traditional techniques. The algorithm’s dependability and ease of implementation, even on highly complicated and non-convex situations, are demonstrated by its excellent results.
Carbon Sinks and Carbon Emissions Discrepancies at Fine Scale for Mega Cities in China
Authors: Wang Lixing
Published: July 2024

Assessing discrepancies between carbon sinks and emissions at the urban scale is crucial for evaluating progress toward carbon neutrality in Chinese cities. Here we developed an integrated model to conduct a high-resolution (250-m, monthly) assessment of carbon emissions and sinks in three mega Chinese city clusters: Beijing-Tianjin-Hebei, Yangtze River Delta, and Pearl River Delta. Our results precisely depicted the seasonal patterns of net carbon emissions (NCE, defined as the difference between carbon emissions and sinks) and various urban carbon dynamics, such as urban villages, industrial zones, green parks. Nearly half of the 48 cities exhibited NCE exceeding 1000 gC∙m−2∙a−1, while only 5 cities function as carbon sinks. The percentage of carbon sinks to emissions in three city clusters ranged from 13–32%, highlighting a significant gap toward achieving carbon neutrality. Our model provides superior resolution and intricate spatial details, offering valuable insights for urban afforestation and emission mitigation policies.
Analysis of the Ecological Toxicity of Pesticides, Heavy Metals and Microbial Pollution and their combined effects, in the Running Surface Water of Jhal Magsi, Pakistan
Authors: Mustafa Safia , Kakar Attiq Ur Rehman , Malik Yasmeen , Khan Naqeebullah , Samad Abdul , Samiullah
Published: July 2024

Monitoring water quality is highly important for ensuring clean drinking water and protection of aquatic environments. The aim of the current study was to estimate the quality of running water sources from the district of Jhal Magsi. This study focused on evaluating the effects of low biodegradability, the accumulation of heavy metals and organics, and the presence of these compounds on water quality. The concentrations of herbicides (DDT (2,4 D) and Cyanazine) and insecticides (chlorpyrifos, Aldrin and Dieldrin) were determined via gas chromatography, and the concentrations of heavy metals (Pb and Cd) and trace elements (Zn and Mn) were detected via an atomic absorption spectrophotometer. Identification of E. coli and P. aeruginosa was performed by Gram staining and biochemical tests. DDT (2,4 D), Cyanazine, Chlorpyrifos, and Aldrin & Dieldrin were detected at 0.9 ± 0.058, 0.08 ± 0.006, 1.01 ± 0.577 and 1.1 ± 0.577 mg/L, respectively; these values are higher than the WHO safety limits. The heavy metals Pb and Cd were detected in all the samples, and the highest range for Pb was 2.03 ± 0.577 mg/L, while that for Cd was 0.48 ± 0.058 mg/L. The highest concentrations of the trace elements Zn and Mn were detected, and the WHO recommended safe limits were 0.305 ± 0.058 and 0.99 ± 0.058 mg/L, respectively. E. coli and P. aeruginosa were identified with percentages of 51.51 and 48.48%, respectively. The presence of higher concentrations of pesticides and heavy metals and their synergistic effect indicate a risk for both human health and aquatic organisms. Therefore, continuous monitoring of heavy metals and pesticides is necessary in the water reservoirs of Jhal Magsi to ensure drink safety. Bacterial assessment can aid in accepting bioremediation processes in water.
Embryology of a Lady’s Slipper Orchid, Paphiopedilum spicerianum and Cytokinin Requirements for Seed Germination and Protocorm Development
Authors: Chen Wei-An , Hsu Shan-Te , Lee Yung-I
Published: July 2024

In this study, we document the primary structural changes that occur during the seed development of Paphiopedilum spicerianum (Rchb.f.) Pfitzer, an endangered species with high horticultural value. Within a defined timeline, our results offer insights into the connection between these structural changes in seeds and their germination percentage. The optimum germination was recorded for immature seeds collected at 180 to 210 days after pollination (DAP), during which the embryos are in the late globular stage and the suspensor begins to degenerate. As seeds continued to mature by 240 DAP, there was a gradual decline in germination. Histochemical staining of mature seeds reveals that only the inner seedcoat and the surface of the embryo exhibit positive reactions to the Nile red stain, suggesting a relatively weak coat-imposed dormancy. This weaker dormancy may contribute to the higher germination observed in mature seeds of P. spicerianum compared with other challenging-to-germinate species. Of the cytokinins examined, 6-(γ,γ-dimethylallylamino)purine (2iP), kinetin (KN), and 6-benzylaminopurine (BA) exhibited a stimulating effect on germination, concurrently enhancing the formation of amorphous protocorms.
Probing pair correlations in Fermi gases with Ramsey-Bragg interferometry
Authors: Malas-Danzé Théo , Dugelay Alexandre , Navon Nir , Kurkjian Hadrien
Published: July 2024

We propose an interferometric method to probe pair correlations in a gas of spin-1/21/2 fermions. The method consists of a Ramsey sequence where both spin states of the Fermi gas are set in a superposition of a state at rest and a state with a large recoil velocity. The two-body density matrix is extracted via the fluctuations of the transferred fraction to the recoiled state. In the pair-condensed phase, the off-diagonal long-range order is directly reflected in the asymptotic behavior of the interferometric signal for long interrogation times. The method also allows to probe the spatial structure of the condensed pairs: the interferometric signal is an oscillating function of the interrogation time in the Bardeen-Cooper-Schrieffer regime; it becomes an overdamped function in the molecular Bose-Einstein condensate regime.
Aspects of categorical symmetries from branes: SymTFTs and generalized charges
Authors: Apruzzi Fabio , Bonetti Federico , Gould Dewi S. W. , Schäfer-Nameki Sakura
Published: July 2024

Recently it has been observed that branes in geometric engineering and holography have a striking connection with generalized global symmetries. In this paper we argue that branes, in a certain topological limit, not only furnish the symmetry generators, but also encode the so-called Symmetry Topological Field Theory (or SymTFT). For a dd-dimensional QFT, this is a (d+1)(d+1)-dimensional topological field theory, whose topological defects encode both the symmetry generators (invertible or non-invertible) and the generalized charges. Mathematically, the topological defects form the Drinfeld center of the symmetry category of the QFT. In this paper we derive the SymTFT and the Drinfeld center topological defects directly from branes. Central to the identification of these are Hanany-Witten brane configurations, which encode both topological couplings in the SymTFT and the generalized charges under the symmetries. We exemplify the general analysis with examples of QFTs realized in geometric engineering or holography.
Biochemical composition of seeds from different pea varieties
Authors: Molodchenkova O. O. , Koblai S. V. , Tykhonov P. S. , Bezkrovna L. Ya. , Ryshchakova O. V. , Levitsky Yu. A. , Untilova I. A.
Published: July 2024

Purpose. To study the biochemical parameters characterising seed quality in pea varieties of different morphotypes for the selection of genotypes with improved nutritional properties. Methods. Seeds of 37 different morphotypes [leafy, leafless, heterophillous (chameleon)] of domestic and foreign pea varieties were studied.  Standard and laboratory developed methods of biochemical analysis of plants (Kjeldahl method, spectrophotometric methods, electrophoresis) were used. The statistical analysis of the research results was carried out using the software LibreOffice Calc (GNU Lesser General Public License v3) and the image analysis software Imagel. Results. The presence of varietal differences in the biochemical parameters studied related to seed quality (protein content, flavonoids, lipoxygenase activity, trypsin inhibitor, lectins), the content of the main fractions of the protein complex (legumin and vicilin) and their ratio in seeds of different morphotypes was established. The electrophoretic and amino acid analyses revealed varietal differences (in the relative content of certain protein components in the electropherogram, the presence/absence of some components in the electrophoretic spectra of vicilin and legumin, and their amino acid composition) that affect the nutritional value of pea seeds. Conclusions. The application of the biochemical criteria studied makes it possible to select varieties of food peas with specific technological parameters.
In silico Therapeutic Potential of Phytochemical from Commiphora leptophloeos Mart. - J. B. Gillett Leaves Essential Oil against COVID-19
Authors: Souza Michel , Droppa-Almeida Daniela , Kodel Helena , Santos Tatiane , Moraes Ashlley , Krause Laiza , Bjerk Thiago
Published: July 2024

The in silico study aimed to suggest phytochemicals from Commiphora leptophloeos leaves essential oil as therapies against coronavirus disease (COVID-19) (or severe acute respiratory syndrome coronavirus 2, SARS-CoV-2). For that, we used molecular docking (MD), absorption, distribution, metabolism, excretion, and toxicity (ADMET) parameters, and pharmacokinetic analysis. MD showed the presence of hydrophobic and hydrogen bonds for nine compounds. β-Selinene and bicyclogermacrene showed the best interaction values with the protein Mpro (ID: 6Y2F) (–5.9) and chimeric receptor complexed with its receptor human ACE2 (ID: 6VW1) (–6.1 and –5.5) proteins, as well as low gastrointestinal and high epithelial absorptions, medium permeability for Caco-2 cells and high epithelial permeability, low oral excretion, and were inhibitors of CYP2C19 and CYP2C9 enzymes. On the other hand, both were not permeable to the blood-brain barrier and inhibitors or substrates for glycoprotein-D, and showed carcinogenic potential, but only β-selinene was considered mutagenic. Although little bioavailable, both presented aspects structurally adequate, being compounds with moderate synthesis difficulty. Therefore, more analyses are necessary to evaluate the mechanism of action and unsatisfactory parameters foreseen in bioinformatic assays.
Designing a Simple Microscope as an Alternative Learning Media with SolidWorks Software
Authors: Adiyatma Jovan , Armanda Rizal Endrya , Setiaji Bayu
Published: July 2024

Microscopes are essential as media or teaching aids for prospective educators to achieve learning goals. However, there are still obstacles in their application in the form of quite expensive costs. Often, educational aids have a sizeable nominal value for a school. Teaching aids are costly and prone to damage or loss if students use them frequently, and it is difficult and expensive to find replacements if they are damaged, so teachers are afraid to use them. To overcome this problem, this study provides another alternative design, namely the design of teaching aids that are still useful and function well for learning through the design of microscope teaching aids. The research method used is a model research design using Solidworks software. The development of learning tools compiled in this study refers to the type of 4-D development (Four-D model), which consists of 4 stages: the define stage, the design stage, the development stage, and the dissemination. The research carried out three stages, namely the definition stage (Define), the design stage (Design), and the development stage (Develop). In the results of the design draft, questions were asked of the informants; it was concluded that a proper microscope was a microscope that worked according to its specifications, namely being able to see tiny or micro-objects. The clarity of the lens and the maximum magnification are also factors in the feasibility of the microscope. This research can be concluded as a simple microscope design using the Solidworks application, which is suitable for use as an alternative learning media. If the design of this tool is to be made, then the selection of materials and mechanisms needs further research and trials.
Moderation of Gender and School Location on the Prediction of Test Anxiety on Physics Students’ Academic Achievement in Waves Motion
Authors: Ocheni Christopher Adah , Okeke Agnes Obianuju , Agah John Joseph , Oguguo Basil C. E. , Ene Catherine Uzo , Ezugwu Ifesinachi Jude , Asongo Stanley T
Published: July 2024

The continuous decline in students’ achievement in physics, especially in wave motion, has become a significant concern among education stakeholders. This study, which examines the moderation of gender and school location in predicting test anxiety on students` achievement in wave motion in physics, offers actionable recommendations for improvement. A correlational research design was adopted. Three research questions and three hypotheses informed the study. A sample of 337 students drawn through a multistage sampling procedure was used for the study. Waves Test Anxiety Inventory (WTAI) and Waves Achievement Test (WAT) instruments were used for data collection. Reliability indices of 0.73 and 0.76 using Cronbach alpha and KR-20 were estimated for WTAI and WAT, respectively. The research questions were answered using regression analysis, while ANOVA and t-test results obtained using Hayes` Process Macro were used to test the hypotheses at a 0.05 significance level. Results showed that test anxiety significantly predicts students` achievement in wave motion. The results showed that the moderation of gender in test anxiety prediction was insignificant. However, the location significantly influenced the prediction of test anxiety on students` achievement in wave motion. It was recommended, among others, that physics teachers ensure that lesson contents are duly covered and that a conducive learning environment, clear instructions, and adequate preparations are made available to students before testing them, thereby potentially improving students' academic performance.
Water quality for citizen confidence: The implementation process of 2020 EU Drinking Water Directive in Nordic countries
Authors: Bayona-Valderrama Ángela , Gunnarsdóttir María J. , Rossi Pekka M. , Albrechtsen Hans-Jörgen , Gerlach Bergkvist Kim Steve , Gardarsson Sigurður M. , Eriksson Magnus , Truelstrup Hansen Lisbeth , Jensen Pernille Erland , Maréchal Judith Y. A. , Myrmel Mette , Persson Kenneth M. , Bjerkén August , Kalheim Frida Celius , Bartram Jamie
Published: July 2024

The European Union Drinking Water Directive aims to protect human health and promote safe water consumption. The 2020 revision, particularly Article 17, directed member states to provide public access to information on drinking water. This update responded to citizen initiatives calling for the active participation of end-users in water services and greater transparency from water utilities. Difficulties in implementing previous versions of the directive highlighted divergences between policy purposes, local capacity to implement, and public response. These divergences are explored through eight case studies of Nordic countries and analysed using the policy implementation framework. We employed a mixed-method, multi-stage approach. Policy formulation was characterized through a literature review, policy design by synthesizing legislative instruments, and policy implementation via an analysis of delivery behaviour based on interviews. We identified the main drivers of the directive's update and contrasted these with the ongoing implementation process in the countries studied. Our results point to a different and highly contextual implementation, which differs from the primary drivers of the policy update, namely, the establishment of public confidence in water services.
Fasiyal sinirin intraparotidal dallanma paternleri ve cerrahi önemi
Authors: Tulacı Kamil Gokce
Published: July 2024

Amaç: Bu çalışmanın amacı fasiyal sinirin intraparotidal dallanma paternlerini, anastomozlarını ve anatomik varyasyonlarını araştırmak ve dallanma paternlerinin cerrahi önemini vurgulamaktır.

Yöntemler: Bu çalışmaya 2018-2023 yılları arasında parotis kitlesi nedeniyle total veya yüzeyel parotidektomi uygulanan ve ameliyat sonunda intraparotidal fasiyal sinirin ana trunkustan itibaren seyrini gösteren fotoğrafları mevcut olan hastalar dâhil edildi. Hastaların fasiyal sinir dallanma ve anastomoz sınıflaması Katz ve Catalano’nun sınıflamasına göre yapıldı ve buna göre analiz edildi.

Bulgular: Çalışmaya dâhil edilme kriterlerini sağlayan 48 hasta dâhil edildi. Hastaların 18 tanesi kadın, 30 tanesi erkek idi. Hastaların yaş ortalaması 57,37 idi. Fasiyal sinir dallanma paternleri analiz edildiğinde en sık olan dallanma paterninin tip 1 olduğu görülmüştür (%41,6). İkinci sıklıkta ise tip 2 (%27,08) dallanma paterni görülmüştür. Tip 3 dallanma hastaların % 20,83’ünde, tip 4 ise hastaların %6,25’inde görülmüştür. En az görülen tipin ise tip 5 dallanma paterni olduğu bulunmuştur (%4,16).

Sonuç: Bu çalışma ülkemizdeki erişkinlerde yapılan, kadavra çalışması olmayan ve fasiyal sinirin intraparotidal dallanma paternini araştıran ilk çalışmadır. Çalışma sonucunda en sık görülen dallanma paterninin tip 1 dallanma paterni olduğu görülmüştür. Parotis bezi cerrahisi ile uğraşan hekimlerin fasiyal sinir intraparotidal dallanma paternlerine hâkim olmasının, başarılı ve komplikasyonsuz bir cerrahi gerçekleştirilebilmesi için önemli olabileceği düşünülmüştür.
An Extensive Pharmacological Evaluation of New Anti-carcinoma CDK1 and SERPINE1 Targeted Compound Homoorientin from T.officinale's with In-depth Molecular Docking and Simulation Studies
Authors: Shaikh Abdul Lateef , Zhou Lin , Zheng Shusen
Published: July 2024

Introduction:

Hepatitis B Virus-Related Hepatocellular Carcinoma (HBV-
HCC) constitutes a formidable global health challenge, demanding an in-depth understanding
of its intricate pathogenesis. The research conducted a comprehensive analysis
of the multifaceted relationship between HBV-HCC. It further examined the potential of
Taraxacum officinale, which could serve as an effective adjunct therapy in treating HBV-
associated HCC. Our approach integrates network pharmacology, pathway analysis,
molecular docking, and dynamics simulations, offering an intricate unraveling of the
molecular mechanisms that underlie T. officinale's potential impact on HBV-HCC.

Method:

Additionally, we delve into microarray analysis to unearth differentially expressed
genes (DEGs) associated with HBV-HCC, molecular docking to validate compound
interactions with key proteins, and molecular dynamics simulations to elucidate
the stability of these interactions. These multifaceted approaches enhance our understanding
of T. officinale's therapeutic potential.

Results:

This work represents a significant advancement toward the development of
more effective strategies for the management of this challenging disease, offering a comprehensive
exploration of T. officinale's therapeutic prowess. Within this multidimensional
framework, we identify CDK1, SERPINE1, and PTGS2 as promising therapeutic targets,
shedding light on the molecular intricacies of disease progression. Further, Homoorientin
from T. officinale's demonstrates a strong binding affinity with proteins CDK1,
SERPINE1, and PTGS2, suggesting a potential synergistic effect in therapeutic applications.
Moreover, our enrichment analysis uncovers a rich tapestry of pathways enriched
in HBV-HCC, providing insights into the multifaceted landscape of disease complexity.

Conclusion:

These findings not only pave the way for potential targeted therapies but also
deepen our comprehension of the intricate molecular underpinnings of HBV-HCC.
This work represents a significant advancement toward the development of more effective
strategies for the management of this challenging disease, offering a multifaceted
exploration of T. officinale's therapeutic potential.

other:

Nil
Green Synthesis of Bioactive Pyrrole Derivatives via Heterogeneous Catalysts Since 2010
Authors: Amina Berrichi , Redouane Bachir
Published: July 2024

1:

Pyrrole derivatives are known as building blocks for the synthesis of biological
compounds and pharmaceutical drugs. Several processes were employed to synthesize pyrroles,
including Hantzsch, Paal-Knorr, and cycloaddition of dicarbonyl compounds reaction. Using
catalysts like nanoparticles, metal salts, and heterogeneous ones was necessary to obtain the
targeted pyrrole structure. Also, to afford more active pyrrole compounds, heterocyclic molecules
such as imidazole or other rings were used in the synthesis as amines. This review presents
heterogeneous catalysts since 2010 for the green synthesis of bioactive pyrroles in a one-pot
multi-component reaction.

:

Additionally, each synthetic method included a demonstration of the suggested mechanisms.
Diakylacetylenedicarboxylate, dicarbonyl group, amines, furans, and acetylene group are
consolidated to yield biological pyrroles through the heterogeneous catalysts. Finally, various
pyrrole-performed activities were displayed, such as antibacterial, anti-inflammatory, analgesic,
and other significant activities.
Synthesis, Spectral Characterization, Molecular Docking Studies, and Biological Evaluation of Pyranoquinolinyl Acrylic Acid (PQAA) Diastereomers as Antibacterial Agents Promoted by Indium (III) Triflate in 1-Butyl-3-Methylimidazolium Tetrafluoroborate Ionic Liquid
Authors: Venkatapathy K. , Magesh C.J.
Published: July 2024

In the present investigation, we report the multistep synthesis of pyranoquinolinyl acrylic
acid (PQAA)/furoquinolinyl acrylic acid (FQAA) diastereomers via perkin condensation and reduction,
followed by one-pot inverse electron demand Diels-Alder reaction among 2,3 dihydropyran,
amine, and aromatic aldehyde mediated by indium (III) triflate in 1-butyl-3-methylimidazolium tetrafluoroborate
(In(OTf)3/ [bmim]BF4) at 25.0-27.0oC. The pyranoquinolinyl acrylic acid/furoquinolinyl
acrylic acid diastereomers were evaluated for their in vitro antibacterial activity. Molecular docking
studies were carried out employing iGEMDOCK software to evaluate the mode of binding between
UDP-N-acetylenolpyruvoyl glucosamine reductase and PQAA adducts. All the pyranoquinolinyl/
furoquinolinyl/tetrahydro-cyclopentaquinolinyl acrylic acid (PQAA/FQAA/CPQAA) diastereomers
were thoroughly characterized by NMR, FT-IR, mass spectral, and CHN analysis.
Thermoablation Using Radiofrequency and Microwaves of Autonomous
Thyroid Nodules: Our Experience
Authors: Mattarello Mee Jung , De Santi Francesca , Mingardi R. , Peron C. , Mazzucco Mauro
Published: July 2024

Introduction: In recent decades, ultrasound-guided thermoablation techniques have
been proposed as a therapeutic alternative to classic surgery or radiometabolic therapy for
thyroid nodes. Important results have been obtained from the use of ultrasound-guided and
ultrasound-assisted ablative techniques, such as Laser (LTA), Radiofrequency (RFA), HIFU
(high-intensity focused ultrasound therapy), and Microwaves ( MWA). Normally functioning
benign thyroid nodes with a local compressive effect or aesthetic problem immediately
represent ideal therapeutic indications. Also, treatments for hyperfunctioning hot nodes have
found space. Further, LTA and RFA are the most used, with greater effectiveness and negligible
side effects.
A review of Viruddha Ahara described in Kushtha (Skin Disease) referred to in the text of Brihattrayi
Authors: Byomesh Upadhyay  , Aruna Ojha  , Rashmi Diwan
Published: July 2024

There have been significant dietary pattern shifts in the current era of globalization. A poor diet is a major contributing cause of many diseases, whereas a healthy diet promotes good health. An unhealthy diet is the most frequent contributor to the rising global disease burden. Ayurveda spoke about Trividha Upasthambha (sub-pillars of the body) and Ahara (food) as vital pillars of a healthy living being. For healthy living, Ayurveda promotes an appropriate kind of diet that provides physical, mental, and social health and nutrition. It can be further elaborated as certain diet and their combinations, which interrupt tissue metabolism, inhibit tissue formation, and have the opposite properties to the tissue these are called Viruddha Anna (incompatible diet). The present article deals with the review of Viruddha Ahara (Incompatible diet) described in the skin disease referred to in the context of Brihattrayi.
Effect of Kaphahara Basti and Rohitakadya Churna in the management of Non-alcoholic Fatty Liver Disease (NAFLD) - A Case Study
Authors: Kaminee Nagraj  , Babita Dash
Published: July 2024

Non - Alcoholic Fatty Liver Disease (NAFLD) is the building of extra fat in the liver cells that is not caused by alcohol. NAFLD can be considered as Santarpanajanya Vyadhi (disease caused by to sedentary lifestyle, faulty dietary habits and lack of physical activities). Kapha, Ama and Meda play a major role in the pathogenesis of NAFLD. One such case of Non- Alcoholic Fatty Liver Disease came to Panchakarma OPD of Pt. Khushilal Sharma Govt. (Auto) Ayurveda College and Institute Bhopal. The patient was managed conservatively through Ayurveda medicine (Rohitakadya Churna) and Panchakarma therapy (Kaphahara Basti). After one month of treatment, all the subjective and objective parameters showed a remarkable response on both subjective and objective parameters. The patient’s condition got better and there was pathological remission shown on the ultrasound. This case study aims to investigate the Ayurvedic therapeutic method and mechanism of action of Kaphahara Basti and Rohitakadya Churna in the management of NAFLD. At the end of the study, it can be concluded that the treatment regimen has a significant role in the management of Non-Alcoholic Fatty Liver Disease.
Management of Avabahuka with Prasarni Taila Nasya and Sthanik Patra Pinda Swedana - A Case Study
Authors: Ruchi Juyal  , Ketan Mahajan  , Amit Tiwari  , Atul Kumar Agrawal
Published: July 2024

Avabahuka is a disease that causes problem in daily routine of an individual like wearing clothes, eating, personal hygiene and work etc. Shoulder joint is the most mobile joint in the body. Clinical presentation and pathogenesis of Avabahuka can be correlated with the symptoms of adhesive capsulitis, which is commonly known as Frozen Shoulder. Panchakarma is the branch of Ayurveda which deal with the purification of the Vitiated Doshas of the body through Shodhana therapy. Nasya is mainly indicated for Avabahuka. Swedana also helps in managing the condition, Avabahuka. The aim of the present study was to evaluate the effectiveness of Nasya Karma and Sthanik Patra Potali Swedana in the management of Avabahuka. A 62 years old male patient came to Panchakarma OPD with an accidental history 3 months ago due to which he suffered with acute pain, swelling and stiffness in right shoulder joint. Patient was unable to move right shoulder joint and to carry out daily activities. Patient took 7 days Panchakarma therapy in which Mukhabhyanga with Prasarni Taila and Mridu Swedana was done. It was followed by Prasarni Taila Nasya. After 7 days of treatment marked relief was seen in the symptoms like pain, stiffness and swelling. The therapies were found significantly effective and clinically safe with no adverse reaction were reported during the treatment period.
Efficacy of Marma Chikitsa in the Pain Management of Tennis Elbow - A Single Case Study
Authors: Deependra Singh Rathore  , Rita Marwaha  , Nisha Bhalerao  , Swatantra Kumar Chourasia
Published: July 2024

Tennis elbow, also known as lateral epicondylitis, is a condition that can result from overuse of the muscles and tendons in the elbow. Tennis elbow is linked to repeated motions of the wrist and arm. Tennis elbow is often due to damage to a specific forearm muscle extensor carpi radialis brevis (ECRB). When the ECRB muscle is weakened from overuse, microscopic tears form in the ECRB tendon where it attaches to the lateral epicondyle of humerus. This leads to pain directly over the outside lateral part of the elbow. 1 to 3% of adult population in each year affects with tennis elbow and it is more common in the dominant arm with symptoms such as pain or burning on the outer part of your elbow, weak grip strength, and tenderness. Many surgical procedures, medications are present today for the treatment of the disease, but it is the need of time to develop some non-invasive techniques for better results. Marma is a concept which helps in achieving this. Marma point is a junction on body where two or more types of tissue meet, such as muscles, veins, ligaments, bones or joints. From common ailments to serious neuromuscular diseases, all can be treated by Marma Chikitsa. Application of pressure to these Marma induces the flow of energy. This case study shows that pain in tennis elbow may be successfully managed by Marma Chikitsa.
Optimalisasi pendidikan informal sebagai alternatif pemertahanan bahasa Jawa
Authors: Alfiah Alfiah
Published: July 2024

Tujuan penulisan ini adalah mendeskripsikan bentuk pengoptimalan upaya pendidikan informal sebagai upaya pemertahanan bahasa Jawa. Penulisan artikel ini dikembangkan dengan menggunakan penelitian deskriptif kualitatif dengan merujuk pada beberapa hasil penelitian yang menggambarkan berbagai fenomena bahasa Jawa di tengah masyarakat Jawa di era kini  sebagai sumber datanya. Data dalam penelitain ini adalah berbagai bentuk-bentuk perubahan yang terjadi di tengah masyarakat Jawa era kini tentang eksistensi bahasa Jawa. Data dikumpulkan dengan teknik simak dan baca. Berdasarkan data yang terhimpun, dianalisis secara kritis berdasarkan fenomena atau peristiwa tertentu yang muncul terkait perkembangan bahasa Jawa dan menggunakan peneliti sebagai instumen utama. Hasil penelitian adalah keluarga merupakan lingkungan keluarga merupakan lingkungan pertama anak dalam hal memperoleh pendidikan dapat tumbuh dan berkembang dengan pemantauan dan pengawasan orang tua dan anggota keluarga lainnya yang hidup satu rumah dengannya. Pola asuh orang tua menentukan bagaimana perkembangan nilai karakter anak. Ibu sebagai salah satu orang yang dinilai paling dekat dengan anak memegang peran yang lebih dominan berperan sebagai pendidik dalam lembaga pendidikan informal. Anak memperoleh bahasa pertama dari bahasa yang digunakan di lingkungannya, terutama ibunya karena orang terdekat bagi anak. Ibu memainkan peran formatif dalam pemerolehan bahasa pertama pada anaknya
Tradisi Tedhak Siten sebagai kearifan lokal budaya Jawa dalam perspektif masyarakat desa Dondong
Authors: Yuniati Kurnia Maudina , Andriyani Atikah , Wijayanti Kenfitria Diah
Published: July 2024

This study aims to describe prosession, philosophical meaning, and equipment of Tedhak Siten tradition in perspective Dondong Village. This study do with ethnographic qualitative study was applied. The data source in this study was informants , place, event, and documents. The primary data in this study were documentation of the, oral data and notes from interviews. Secondary data in this study are there documents related. The sample was selected using the purposive and snowball sampling techniques. The data were collected through interviews, natural observation, and document analysis. The data were validated using method and data source triangulation and informants’ review. The obtained data were analyzed using the taxonomy analysis technique. The study finding is described the procession or Tedhak Siten in perspektif Dondong Village and preservation with study class.
Kajian sosial budaya moda transportasi tradisional sampan Leper Indragiri Hilir
Authors: Afriadi Deni , Jefrizal Jefrizal , Idayanti Iik
Published: July 2024

Penelitian ini fokus pada kajian sosial budaya tentang keberadaan Sampan Leper di Desa Pekan Arba Kecamatan Batang Tuaka, Kabupaten Indragiri Hilir, Provinsi Riau. Moda transportasi tradisional ini sudah ada sejak puluhan tahun yang lalu dan masih menjadi moda transportasi di tengah perkembangan dan banyaknya pilihan moda transportasi modern. Kajian ini menelaah  keberadaan, peran serta fungsi Sampan Leper di tengah masyarakat Indragiri Hilir. Penelitian ini merupakan penelitian kualitatif dengan menggunakan teknik pengumpulan data analisis, wawancara dan dokumentasi. Adapun hasil dari penelitian ini menjabarkan tentang kondisi Sampan Leper, karakteristik masyarakat pengguna, fungsi sosial budaya, peran pelaku dan instansi terkait, pewarisan dan nilai sosial budaya. Sampan leper telah menjadi bagian integral dari kehidupan sehari-hari masyarakat di kawasan ini, terutama sebelum adanya pembangunan jembatan yang menghubungkan berbagai kampung. Pembangunan infrastruktur memang memberikan banyak manfaat, namun ada kekhawatiran bahwa tradisi dan kearifan lokal, seperti penggunaan sampan leper, dapat terancam punah jika tidak ada upaya yang dilakukan untuk melestarikannya.
Karakteristik wali Allah dalam serat Andhaning Gesang
Authors: Prastya Gagat Bangun , Ekowati Venny Indria
Published: July 2024

Dalam perspektif Agama Islam manusia dapat dikategorikan menjadi beberapa kelompok. Salah satu aspek yang dapat dijadikan sebagai kategorisasi adalah aspek keimanan manusia terhadap Allah swt. Dalam naskah Jawa Serat Andhaning Gesang terdapat empat tingkatan manuia salah satunya adalah tingkatan kawas atau wali. Penelitian mengenai wali Allah ini dilakukan untuk mengetahui krakteristik wali Allah yang ada dalam naskah Jawa Serat Andhaning Gesang. Subjek utama yang digunakan dalam penelitian ini naskah Jawa Serat Andhaning Gesang. Selain itu juga digunakan sumber lain yang berwujud buku dan jurnal sebagai sumber tambahan. Penelitian ini berbasis studi kepustakaan serta dalam penjabarannya menggunakan metode deskriptif kualitatif. Hasil dari penelitian ini menjabarkan bahwa terdapat lima karakteristik wali Allah yang terdapat dalam naskah Jawa Serat Andhaning Gesang diantaranya adalah: 1) Wali memiliki keilmuan yang tinggi; 2) Wali memiliki kelebihan; 3) Wali memiliki hati yang bersih; 4) Wali menjadi panutan bagi masyarakat; dan 5) Wali senantiasa diberikan kemudahan dalam hidupnya.
The Indonesian version of Individual Work Performance Questionnaire (IWPQ): Structure factor and criterion validity
Authors: Widyastuti Tria , Ramdani Zulmi , Alim Syahrul , Harlianty Rully Afrita
Published: July 2024

The aims of this study are to examine the structure factor of Indonesian version of Individual Work Performance Questionnaire (IWPQ) and to test the construct of IWPQ by correlating with Utrecht Work Engagement Scale (UWES) as criterion. A total of 609 data from employees across Indonesia were involved in the research (Study 1 = 231, and Study 2 = 378). Data analysis was done using CFA to test the evidence validity based on internal structure and Pearson correlation to examine evidence of validity based on relation to other variables. This study confirmed the three-factor model of IWPQ in study 1 and study 2 with independent samples. The Indonesian version of the IWPQ also correlate positively with work engagement as criterion proving the evidence validity based on relation to others variable. The finding of this research strengthens the Indonesian version of IWPQ as a good tool in measuring work performance
COMPARISON OF BIM-BASED QUANTITIES TAKE-OFF IN QUANTITY SURVEYING PROFESSION
Authors: Soon Lam Tatt , Wong Lik Syuen , Kamarazaly Myzatul Aishah , Saar Chai Chang , Sheikh Ilmi Habizah
Published: July 2024

Quantity surveyor (QS) plays an important role in a construction project who is responsible for the construction cost. Quantity take-off (QTO) will be conducted by QS to measure the quantities of materials needed for the construction project followed by the preparation of bills of quantities (BQ). Building information modelling (BIM) was introduced to the construction industry and brings many benefits to the QTO process such as time saving and high accuracy. However, BIM-based QTO consists of numerous issues such as 3D modelling issues, quantities extraction issues and data loss issues. Hence, this research aims to compare and analyse the application of BIM-based QTO in the QS profession. The objectives of this research cover the comparison of BIM-based QTO in BIM software as well as the analysis of quantities extraction which complies with Malaysian Standard Method of Measurement of Building Works Second Edition (SMM2). This research was conducted by using two types of BIM software which are Autodesk Revit and Cubicost TAS. This research is expected to benefit the QS profession by delivering a better understanding of using BIM for QTO with the analysis and comparison of QTO data.
SEISMIC RESILIENCE OF CFRP CONFINED RC COLUMNS: EXPERIMENTAL ANALYSIS
Authors: Abdul Halim Nur Hajarul Falahi , Mustapa Fara Diva , Ismail Mohamad Zahierrudien
Published: July 2024

Resilience and sustainability are the key goals of any building and infrastructure, especially in countries with moderate to high seismicity. However, in countries with low seismicity like Malaysia most existing buildings are designed to carry only the gravity load, which is vulnerable when subjected to additional loads such as earthquakes. Lateral ground motion can severely damage vital components like columns in the form of concrete crushing associated with the buckling of longitudinal reinforcement. This paper presented the application of fibre-reinforced polymer (FRP) as reinforcement in RC columns based on experiments for resilience and sustainability of RC structure. The application of FRP for retrofitting and strengthening structural elements not only increased the axial, shear and bending capacity, but also high durability towards harsh environment. CFRP in sheets/strips were flexible as compared to FRP bars; therefore, they can easily be shaped into spirals to confine the core concrete of column. This study showed that by using FRP sheets as internal confinement improved the seismic response of RC columns better than the conventional carbon steel material. A discussion on the performance of FRP sheets as internal confinement and their potential in improving the resilience and robustness of RC structures was presented for future directions.
IMPLEMENTATION OF ZERO WASTE CONCEPT IN MALAYSIA: FROM CONTRACTORS’ PERSPECTIVE
Authors: Sheikh Ilmi Habizah , Yee Jing Wen , Kam Kenn Jhun , Lim Tze Shwan , Soon Lam Tatt
Published: July 2024

Construction waste is one of the major contributions to severe environmental issues. However, this construction and demolition (C&D) waste issue is often neglected by the stakeholders. Instead, they focus more on cost, time and quality as their priority. In Malaysia, the lack of knowledge and awareness of sustainable zero waste practices have become a major obstacle to sustainable development in the construction industry. To address this, the implementation of Zero Waste concept should be widely promoted to reduce the solid waste production and mitigate the depletion of natural resources. Hence, this study is to identify the challenges of implementing zero waste concept among the contractors. This research focuses on building contractors by using a quantitative research method to collect data from the targeted population. The findings of the study highlight that waste reduction, curbing illegal dumping and reducing public health risks are the primary concerns in relation to the Zero Waste concept. The study reveals that contractor’s attitude and reluctant behaviour, inadequate policies and the absence of mandatory zero waste management are the main barriers for the implementation of zero waste concept in Malaysia. The government should play an important role to develop C&D waste concept and to identify suitable C&D waste models which can be used in Malaysia. By adopting zero waste concept, the construction industry in Malaysia can move towards a more sustainable future and develop its sustainability targets under Sustainable Development Goal (SDG) 12.