bluuebunny/crossref_metadata_2025 huggingface dataset:
Brain modulation after exergaming training in advanced forms of Parkinson’s disease: a randomized controlled study
Authors: Skrzatek Anna , Nuic Dijana , Cherif Saoussen , Beranger Benoit , Gallea Cecile , Bardinet Eric , Welter Marie-Laure
Published: March 2024

Background.
Physical activity combined with virtual reality and exergaming has emerged as a new technique to improve engagement and provide clinical benefit for gait and balance disorders in people with Parkinson’s disease (PD).
Objective.
To investigate the effects of a training protocol using a home-based exergaming system on brain volume and resting-state functional connectivity (rs-FC) in persons with PD.
Methods.
A single blind randomized controlled trial was conducted in people with PD with gait and/or balance disorders. The experimental (active) group performed 18 training sessions at home by playing a custom-designed exergame with full body movements, standing in front of a RGB-D Kinect® motion sensor, while the control group played using the computer keyboard. Both groups received the same training program. Clinical scales, gait recordings, and brain MRI were performed before and after training. We assessed the effects of both training on both the grey matter volumes (GVM) and resting-state functional connectivity (rsFC), within and between groups.
Results.
Twenty-three patients were enrolled and randomly assigned to either the active (n = 11) or control (n = 12) training groups. Comparing pre- to post-training, the active group showed significant improvements in gait and balance disorders, with decreased rs-FC between the sensorimotor, attentional and basal ganglia networks, but with an increase between the cerebellar and basal ganglia networks. In contrast, the control group showed no significant changes, and rs-FC significantly decreased in the mesolimbic and visuospatial cerebellar and basal ganglia networks. Post-training, the rsFC was greater in the active relative to the control group between the basal ganglia, motor cortical and cerebellar areas, and bilaterally between the insula and the inferior temporal lobe. Conversely, rs FC was lower in the active relative to the control group between the pedunculopontine nucleus and cerebellar areas, between the temporal inferior lobes and the right thalamus, between the left putamen and dorsolateral prefrontal cortex, and within the default mode network.
Conclusions.
Full-body movement training using a customized exergame induced brain rs-FC changes within the sensorimotor, attentional and cerebellar networks in people with PD. Further research is needed to comprehensively understand the neurophysiological effects of such training approaches.
Trial registration:
ClinicalTrials.gov NCT03560089
SAP30 promotes clear cell renal cell carcinoma proliferation and inhibits apoptosis through the MT1G/P53 axis
Authors: Xue Wei , Guo Wei , Wang Shuwen , Dong Yu , Yang Zitong , Xia Zhinan , Zhang Cheng
Published: March 2024

Sin3-associated polypeptide p30(SAP30) is an important component of the SIN/HDAC histone deacetylase complex that act as a scaffolding and facilitates target gene binding. SAP30 is highly expressed in a variety of tumors, however; its role in renal cell carcinoma is still unclear. In our study, we found that SAP30 was upregulated in tissues of renal clear cell carcinoma (ccRCC), and high SAP30 expression was associated with a poor prognosis. According to relevant studies, SAP30 may be associated with the growth, proliferation and apoptosis of renal cell carcinoma cells, and GO analysis of SAP30 downstream regulatory target genome showed that SAP30 repressed the expression of MT1G, a P53-binding protein. Mechanistically, SAP30 inhibits MT1G expression at the transcriptional level, reducing the ability of MT1G to deliver to zinc ions to P53, thus reducing P53 activity, and the downregulation of MT1G also attenuates the inhibition of MDM2, thereby reducing the stability of P53, which ultimately promotes the development of renal cell carcinoma. In summary, our study shows that SAP30 inhibits the P53 pathway by inhibiting MT1G, suggesting that SAP30 and MT1G may become markers of renal cell carcinoma prognosis and therapeutic targets.
Traveling salesman games: semicore allocations for collaborative transportation in short food supply chains
Authors: Besson Nicolas , Bouveret Sylvain , Brauner Nadia , Brulard Nicolas
Published: March 2024

In this paper we study semicore allocations for Traveling Salesman Games (TSG) in the context of a development of a Decision Support System (DSS) for collaborative transportation in Short Food Supply Chains. The aim of the DSS we propose is to help a group of agents (in our case, farmers) to pool collect and delivery facilities by proposing (i) an optimal solution for the transportation problem and (ii) a practical method to allocate induced costs among the agents in an explainable and fair way. We argue that the semicore is a seemingly reasonable solution concept for this particular context. Finding allocations in the semicore is less computationally demanding than in other solution concepts such as the core while conveying fairness concepts that can be arguably easily understood without a deep understanding of mathematical language, as opposed to other methods from cooperative game theory (such as the Shapley value or the nucleolus). Applying this concept to the context of a DSS naturally raises the question of whether there could be instances of the TSG that can have an empty semicore (like it can be the case for the core). In this paper we first provide a necessary and sufficient condition for the semicore of an instance of the TSG to be empty. Then, we prove that the set of cost functions that characterize Symmetric TSGs is a union of polyhedra. With this characterization in hand implemented in the form of an SMT program, we are able to exhibit instances of the symmetric TSG where the semicore is indeed empty, and to give some insights on other cases where the solver cannot find any. We advocate that precisely knowing when the semicore can be empty is crucial for the DSS we aim to develop, to warn the stakeholders in some situations that a fair allocation might not exist. Finally, we conclude by giving a short feedback on the proof of concept of a first version of our DSS, tested in practice by members of an association of farmers.
The diagnostic efficiency and safety of transbronchial lung cryobiopsy using 1.1-mm cryoprobe in diagnosing interstitial lung disease
Authors: Bian Yiding , Deng Mingming , Gao Qian , Zhou Guowu , Tong Run , Zhao Ling , Liu Min , Sun Jie , Dai Huaping , Herth Felix JF , Hou Gang , Wang Chen
Published: March 2024

Introduction: Transbronchial lung cryobiopsy (TBLC) is increasingly used to diagnose interstitial lung disease (ILD). The 1.1-mm cryoprobe has recently been available in clinical practice. The diagnostic yield and safety of TBLC using a 1.1-mm cryoprobe need to be confirmed.
Methods: A prospective, randomized controlled trial was conducted in patients with suspected ILD and randomly assigned to 1.1-mm and 1.9-mm cryoprobe groups. The primary outcome was the diagnostic yield of multidisciplinary discussion (MDD). Secondary outcomes were sample quality and incidence of complications. The tension and stress effects during TBLC onto the target lobe caused by 1.1-mm, 1.9-mm, and 2.4 mm cryoprobes were also evaluated using finite element analysis.
Results:A total of 224 patients were enrolled. No significant differences were observed in the diagnostic yield (80.4% vs. 79.5%, p=0.845) and sample quality scores (5.73±0.64 vs. 5.66±0.77; p=0.324) between the 1.9-mm cryoprobe group and 1.1-mm cryoprobe group. The average surface areas of samples in 1.1-mm cryoprobe group were smaller, while no difference in sample weights was observed. A decreased incidence of moderate bleeding was found in the 1.1-mm cryoprobe group (17.0% vs. 6.2%, p=0.027), while the incidence of pneumothorax was higher in the 1.1-mm cryoprobe group but did not reach statistical significance (1.8% vs. 7.1%, p=0.070). In finite element analysis, the 1.1-mm cryoprobe required the largest tension and produced the largest stress.
Conclusion:Compared with a 1.9-mm cryoprobe, there was no difference in specimen quality or diagnostic rate but smaller sample size with a 1.1-mm cryoprobe.
Trail registration: clinicaltrials.gov identifier NCT04047667; registered August 4, 2019
Exploring the Trends in Sediment and Phosphorus Concentrations and Loads in Part of the Canadian Great Lakes Basin
Authors: Paul Pranesh Kumar , Goswami Anant , Rudra Ramesh Pall , Goel Pradeep Kumar , Daggupati Prasad
Published: March 2024

The specific objective of this study is to explore the long-term trend of total phosphorus (TP) and total suspended sediment (TSS) concentrations and loads (C/L)s in various streams/rivers in the Great Lakes Basin. This includes related statistical analyses, such as confidence intervals, to assess variability and identify cases where measures should be taken to reduce TSS and TP. Trend analysis of TSS and TP (C/L)s are performed, combining bootstrapping with the Weighted Regressions on Time, Discharge, and Season i.e., WRTDS_BT technique. The technique is used at ten selected monitoring stations of Northern Lake Erie, Eastern Lake Huron, and Lake Ontario & Niagara Peninsula in Ontario, Canada. Trend analysis over selected tributaries using flow-normalized (FN) TSS and TP (C/L)s reveals that trends in [FN-TSS] and [FN-TP] (C/L)s were highly variable, with significant decrease in a few stations. However, in most tributaries, TSS concentration levels are significantly higher than Canadian Water Quality Guidelines (CWQG) limit of 30 mg/L (following Toronto Region Conservation Authority (TRCA), Ontario) and TP concentration levels are significantly higher than the Ontario’s provincial water quality objectives (PWQO) limit of 0.03 mg/L. Measures to reduce TSS and TP is effective at five tributaries (Humber River, Don River, Saugeen River, Big Creek, Nottawasaga River). Although the drivers are not explicitly identified, potential attributions are discussed for policymakers in the study area.
Unconditionally positivity-preserving approximations of the Ait-Sahalia type model: Explicit Milstein-type schemes
Authors: Jiang Yingsong , Liu Ruishu , Wang Xiaojie , Zhuo Jinghua
Published: March 2024

The present article aims to design and analyze efficient first-order strong schemes for a generalized A ̈ıt-Sahalia type model arising in mathematical finance and evolving in a positive domain (0, ∞), which possesses a diffusion term with superlinear growth and a highly nonlinear drift that blows up at the origin. Such a complicated structure of the model unavoidably causes essential difficulties in the construction and convergence analysis of time discretizations. By incorporating implicitness in the term α-1x−1 and a corrective mapping Φh in the recursion, we develop a novel class of explicit and unconditionally positivity-preserving (i.e., for any step-size h > 0) Milstein-type schemes for the underlying model. In both non-critical and general critical cases, we introduce a novel approach to analyze mean-square error bounds of the novel schemes, without relying on a priori high-order moment bounds of the numerical approximations. The expected order-one mean-square convergence is attained for the proposed scheme. The above theoretical guarantee can be used to justify the optimal complexity of the Multilevel Monte Carlo method. Numerical experiments are finally provided to verify the theoretical findings.
AMS subject classification: 60H35, 60H15, 65C30.
High Performance Lithium Ion-conducting Plasticized Biopolymer Electrolyte for Supercapacitor Application
Authors: M Nandhinilakshmi , D Vanitha , N Nallamuthu , K Sundaramahalingam , P Saranya , A Shameem
Published: March 2024

Lithium-ion based Solid Polymer Electrolytes are synthesized by incorporating lithium perchlorate (LiClO4) salt with Iota-Carrageenan (IC) / Acacia Gum (AG) plasticized with ethylene glycol (EG) by solution casting method. The X-ray diffraction and Fourier transform infrared analysis are used to analyze the structural and molecular complexation. AC impedance analysis spectra show that the incorporation of 15 wt. % of LiClO4 salt into a blend polymer electrolyte (IAO15) shows the ionic conductivity of 2.02 ×10− 2 S/cm and minimum activation energy (0.022 eV). The conduction mechanism for IAO15 sample follows two models (CBH and QMT). The dielectric and modulus spectra confirm the non-Debye nature of the sample. From the Transference Number Measurement, it is observed that the conductivity is due to Li ions and IAO15 sample is chosen for the fabrication of a Symmetrical supercapacitor. At 3.6 Ag− 1 current density, the power and energy densities are noted as 7452 Wkg− 1 and 165.6 Whkg− 1 respectively.
Thickener behaviour in rolling elastohydrodynamic lubrication contacts
Authors: Okál Michal , Kostal David , Sakai Kazumi , Krupka Ivan , Hartl Martin
Published: March 2024

This paper focuses on the study of thickener behaviour in elastohydrodynamic contacts using fluorescence microscopy and optical interferometry. A standard Ball-on-disc configuration tribometer was used as well as a newly developed Ball-on-ring configuration tribometer mimicking the conditions in a 6314 deep groove ball bearing. Three types of custom-made greases were used with the same base oil and Coumarin 6 fluorescent dye on the thickener. These greases contained no additives and were of the lithium complex and alicyclic di-urea type. It was confirmed that the behaviour of the grease was directly influenced by both the structure and type of thickener, and the differences were successfully observed by fluorescence microscopy. The concentration of thickener was found to change due to the formation or breakdown of the deposited thickener layer on the track. At low speeds, the alicyclic di-urea forms a thickener layer on the track that is more pronounced than the lubricating film formed by the base oil alone. The thickener layer formation also occurs at higher speeds when fully flooded conditions are beneficial in building the layer. Experiments with a Ball-on-ring tribometer show that the natural replenishment of the real contact geometry is more effective than on a Ball-on-disc tribometer, but the formation of the thickener layer on the track is more limited than in a Ball-on-disc tribometer with artificial replenishment. At higher velocities, a smaller but stable layer is formed where the layer does not change much from a certain velocity.
Deep Migration Learning-based Recognition of Diseases and Insect Pests in Yunnan Tea under Complex Environments
Authors: Li Zhaowen , Sun Jihong , Shen Yingming , Yang Ying , Wang Xijin , Wang Xinrui , Tian Peng , Qian Ye
Published: March 2024

Background
The occurrence, development, and outbreak of tea diseases and pests pose a significant challenge to the quality and yield of tea, necessitating prompt identification and control measures. Given the vast array of tea diseases and pests, coupled with the intricacies of the tea planting environment, accurate and rapid diagnosis remains elusive. In addressing this issue, the present study investigates the utilization of transfer learning convolution neural networks for the identification of tea diseases and pests. Our objective is to facilitate the accurate and expeditious detection of diseases and pests affecting the Yunnan big-leaf sun-dried green tea within its complex ecological niche.
Results
Initially, we gathered 1878 image data encompassing 10 prevalent types of tea diseases and pests from complex environments within tea plantations, compiling a comprehensive dataset. Additionally, we employed data augmentation techniques to enrich the sample diversity. Leveraging the ImageNet pre-trained model, we conducted a comprehensive evaluation and identified the Xception architecture as the most effective model. Notably, the integration of an attention mechanism within the Xeption model did not yield improvements in recognition performance. Subsequently, through transfer learning and the freezing core strategy, we achieved a test accuracy rate of 99.17% and a verification accuracy rate of 96.3889%.
Conclusions
These outcomes signify a significant stride towards accurate and timely detection, holding promise for enhancing the sustainability and productivity of Yunnan tea. Our findings provide a theoretical foundation and technical guidance for the development of online detection technologies for tea diseases and pests in Yunnan.
Development and Optimization of a NovelPassive Shim System for Human OrbitofrontalCortex Imaging at 4T MRI
Authors: Jayatilake Mohan Lal , Vijithananda Sahan , Lee ing-Huei
Published: March 2024

Background: The orbitofrontal cortex (OFC) area plays a critical role in humanbrain functions. However, susceptibility differences between paranasal sinuses andnasal cavity tissues often cause local field variations in the OFC region duringMRI, resulting in image distortions and signal loss. This paper introduces asubject-friendly neck passive shim solution aimed at enhancing field homogeneityin the brain, specifically in the OFC region.
Methods: Utilizing 3D gradient-echo pulse sequences, main magnetic field (B0)maps of four subjects’ brains were acquired at 4T MRI. Subsequently, these mapswere decomposed into spherical harmonic coefficients which were then averaged.Optimal positions for placing shim elements on a semi-cylindrical surface, whichwas positioned slightly above the neck and below the chin, were computed.
Results: The findings indicate a substantial enhancement in B0 homogeneity, particularly within the OFC region, through the integration of thissemi-cylindrical passive shim system in conjunction with the first andsecond-order active shimming.
Conclusion: Utilizing a local dipole passive shim field shows potential forimproving field homogeneity in the orbitofrontal region of human brain.
Flow Tweezing of Anisotropic Magnetic Particles in a Dynamic Magnetic Trap
Authors: Liu Yuan , Cao Quanliang , Xu Haifeng , Lin Gungun
Published: March 2024

Unravelling the dynamics of anisotropic particles in fluids is critical for a range of applications in micro-robotics, lab-on-chip biochemical assays, environmental remediation, and purification. However, controlled transport of an anisotropic particle in a fluidic flow has proven nontrivial owing to the coupling of the particle’s rotation movement with the hydrodynamic flow, leading to complex flow trajectories and motion dynamics. Here, we report the dynamic tweezing of an anisotropic magnetic particle structure in a rotating magnetic trap. We reveal a series of unconventional motion modes and dynamics of the particle transporting in a confined fluidic flow, which manifest themselves as transitions from on-trap centre rolling to large-area revolution and off-trap centre rolling with varying rotating frequencies. The revolution of a particle is observed to shift to off-centre rolling at varied flow velocities, which is absent for the common scenario when the particle is purely trapped in a medium flow. Our findings unlock a new strategy to determine local magnetic tweezing force profile and flow conditions in arbitrary flow channels, revealing strong potential for microfluidics, chemical reactors and in-vivo endovascular flow measurement.
Effect of platelet-rich plasma (PRP) binding CTRP9 mediated PUM1-TLR4 on chondrocyte proliferation, apoptosis and oxidative stress in osteoarthritis
Authors: Li Baosheng , Dong Jigang , Wang Hongrui
Published: March 2024

Purpose: Platelet-rich plasma (PRP) is now widely used in the treatment of osteoarthritis. C1q/tumor necrosis factor-related protein-9 (CTRP9) is a newly discovered protein with remarkable anti-inflammatory, anti-oxidant and anti-apoptotic properties. We investigated whether PRP and CTRP9 could act synergistically to regulate the proliferation and apoptotic process of chondrocytes from osteoarthritis patients, as well as the response to oxidative stress by interfering with the PUM1-TLR4 signaling pathway.
Methods: CTRP9 was transfected into HC-OA cells using lentiviral vectors and grouped by adding PRP; cell viability and proliferation were detected by CCK-8 and plate cloning assay; chondrocyte apoptosis was detected by flow cytometry; an OA mouse model was established by anterior cruciate ligament transection (ACLT); bone damage was visualized by toluidine blue staining; the expression of CTRP9, PUM1 and TLR4 in cells and tissues were detected by WB and qRT-PCR; WB detected the expression of apoptotic proteins (Bcl-2, Bax and Caspase-3) in arthritic cells and tissues; ELISA detected the expression of IL-1β, TNF-α and IL-6 as well as GSH, MDA and SOD in cells and tissues.
Results: In cellular experiments, HC-OA group exhibited a reduction in cell viability, an increase in apoptosis rate, and elevated levels of inflammatory response and oxidative stress, while overexpression of CTRP9 and addition of PRP enhanced cell viability and diminished apoptosis rate., and alleviated inflammatory response and oxidative stress, and both of them acted simultaneously with better effect. In animal experiments, in comparison to the model group, overexpression of CTRP9 and addition of PRP resulted in increased expression of CTRP9 and PUM1, decreased TLR4, decreased Bax and Caspase-3, increased Bcl-2, and reduced inflammatory response and oxidative stress, and the effect of both simultaneous actions was more obvious. These results suggest that PRP synergized with CTRP9 can reduce the pathological response of osteoarthritis and is expected to be used as a therapeutic approach for osteoarthritis. Conclusion: Platelet-rich plasma (PRP) combined with CTRP9 stimulates the proliferation of arthritic chondrocytes and reduces apoptosis by up-regulating PUM1 and decreasing TLR4, thereby reducing the body's oxidative stress and inflammatory response.
Angelica sinensis polysaccharides promote extramedullary stress erythropoiesis via ameliorating splenic glycolysis and EPO/STAT5 signaling-regulated macrophages
Authors: Sun Nianci , Wang Ziling , Jiang Honghui , Wang Biyao , Du Kunhang , Huang Caihong , Wang Cheng , Yang Ting , Wang Yaping , Liu Yafei , Wang Lu
Published: March 2024

Background
Extrinsic molecular mechanisms that regulate extramedullary stress erythropoiesis are still poorly understood, and the exploration of potential protective medication is needed.
Materials and methods
Peripheral blood parameters and BFU-E colony enumeration were measured. IHC staining was conducted to detect the proliferation of splenocytes and splenic F4/80 macrophages. The expression of β-catenin protein in RAW264.7 macrophages was assessed using immunofluorescence. The cell cycle of mouse spleen c-kit+ cells was analyzed by flow cytometry assay. Detection of Ccl2, Hk2, and Pgk1 mRNA expression by RT-qPCR. Cyclin D1 protein expression was assessed using Western blotting. IL-1 and EPO levels were determined by ELISA assay.
Results
In the 5-FU pre-administrated mouse, ASP rescued peripheral blood parameters such as RBC counts, HGB, HCT and MCH, and the BFU-E colony enumeration in the bone marrow. Meanwhile, ASP increased cellular proliferation in the splenic red pulp and cyclin D1 expression, ASP increased macrophage chemokine Ccl2 genetic expression and the number of F4/80 macrophages in the spleen and splenic BFU-E enumeration. Furthermore, ASP facilitated glycolytic genes including Hk2, Pgk1, Pkm, Pdk1 and Ldha via PI3K/Akt/HIF2α signaling in the spleen. Subsequently, ASP declined pro-proinflammatory factor IL-1β, whereas upregulating erythroid proliferation-associated genes Gdf15, Bmp4, Wnt2b, and Wnt8a. Moreover, ASP facilitated EPO/STAT5 signaling in splenic macrophages to enhance erythroid lineage Gata2, Gata1 genetic expression. Also, ASP facilitated erythroid differentiation via macrophage-mediated EpoR/STAT5 signaling.
Conclusions
ASP facilitate extramedullary stress erythropoiesis that suggest it might be a promising strategy for stress anemia treatment.
The Communication Convergence of Journalism and Public Releases
Authors: Tielietov Oleksandr , Tielietova Svitlana
Published: March 2024

Introduction. The article examines the essential characteristics of the journalism and PR convergence, the main reasons for this process, the key aspects of the specified mass communication types of interaction, the principles of media relations, the probable scenarios of the integration development of the journalism and PR and its consequences for both spheres are clarified.
Relevance of the study. The study of various aspects of the interaction of media and public relations is extremely relevant, since in the modern media landscape these communicative practices increasingly influence each other. Understanding the consequences of their convergence helps to define new creative approaches to communication strategies, to adapt them to modern realities. The purpose of the article is to determine the convergent processes features, that have recently been taking place in the journalism and public relations field.
Methodology. The research was carried out using the analysis of scientific sources, an analytical method, a systematic approach when considering the dynamics and relationship at different levels between journalism and public relations, a comparative method for identifying their common and distinctive features, monitoring the media space, which allows to find out the impact of certain PR strategies and tools for journalistic practices, method of theoretical generalization.
The results. The main principles of media relations are indicated: the principle of trust, the reliability of information, bilateral observance of interests, consideration of development trends, communication style and ethical standards. The main convergent processes of journalism and public relations include: the use of similar tools and methods to achieve goals, the joint content creation that satisfies the needs of both parties, the joint management of information flows, the combination of journalistic approaches to the materials creation with PR strategies for attracting attention, the formation of the general professional responsibility sphere, conducting joint information campaigns and other events, creating a new media text format that combines the journalistic and PR text features, using the Internet as a channel, means and medium of communication.
Conclusions. The novelty of the research consists in obtaining a clearer idea of the various mass communication types of hybridization in the digitalization of society conditions. As a result of convergent processes, journalism and public relations are becoming increasingly interdependent, which opens new opportunities for creating and disseminating information. This interaction leads to the transformation of both spheres, promotes their development, and increases the effectiveness of influencing the audience.
TÜRKİYE’DE BOŞANMA SONRASI BİRLİKTE EBEVEYNLİK DENEYİMLERİ: NİTEL BİR ÇALIŞMA
Authors: Erdemir Aşıkoğlu Berna , Sağkal Ali Serdar , Özdemir Yalçın
Published: March 2024

Bu araştırmada, nitel araştırma yöntemlerinden fenomenolojik yaklaşım ile eski eşlerin boşanma sonrası birlikte ebeveynlik deneyimleri ve algıları incelenmiştir. Amaçlı örnekleme yöntemlerinden ölçüt örnekleme tekniği kullanılarak ölçütleri karşılayan resmi olarak boşanmış 0-18 yaş aralığında çocuk sahibi olan 14 çift (28 yetişkin) araştırmaya katılım sağlamıştır. Veri toplama süreci kuramsal açıklamalar, ampirik bulgular ve uzman görüşleri dikkate alınarak oluşturulan Demografik Bilgi Formu ve Yarı Yapılandırılmış Görüşme Formu aracılığıyla gerçekleştirilmiştir. Eski eşler ile yüz yüze veya çevrim içi görüşmelerin gerçekleştirilmesinin ardından elde edilen sözel veriler içerik analizi yöntemiyle incelenmiştir. Araştırma bulguları genel olarak değerlendirildiğinde, katılımcıların boşanma sonrası çocuk yetiştirme süreçlerinde birlikte hareket etmeye ve ortak karar vermeye çalıştıkları fakat bu süreçlerin anne temelli ilerlediği veya sorumluluğun daha çok annede olduğu; babanın gerekli durumlarda destek sunduğu ebeveynlik ilişkilerinin de yaygın olduğu görülmüştür. Eski eşler arasında çocuk yetiştirme süreçlerinde anlaşmazlıkların ise ebeveynlik stili ve davranışlarındaki farklılıklardan kaynaklandığı belirlenmiştir. Eski eşlerin, ebeveynlik ilişkileri içerisindeki olumsuzluklara çocuklarının tanıklık etmeleri durumunda çocuklarda duygu durum sorunları, davranış sorunları, aile sistemine ve ebeveyne tepkisellik gibi etkiler gözlemledikleri belirlenmiştir.
Withdrawn: The crisis communication of the COVID-19 pandemic in media discourse: Text mining for infectious disease frames and environmental pollution
Authors: Li Yuhang , Zeng Zhifa , Yu Lisai
Published: March 2024

AQUA — Water Infrastructure, Ecosystems and Society issues a formal withdrawal in relation to the above article by Yuhang Li, Zhifa Zeng and Lisai Yu. This decision has been taken due to concerns related to misconduct of a specific editor and their handling of submissions. The editor has been dismissed from the Editorial Board of AQUA — Water Infrastructure, Ecosystems and Society.
Vulnerability of maize, barley, and wheat yields to growing season temperature and socioeconomic indicators in Morocco
Authors: Achli Soumia , Epule Terence Epule , Dhiba Driss , Salih Wiam , Chehbouni Abdelghani
Published: March 2024

In Morocco, the historical record depicts a situation characterized by increasing temperatures and diminishing precipitation, which often ends up in severe drought episodes. This research examines the vulnerability of wheat, barley, and maize to growing season temperature changes as well as socio-economic adaptive capacity proxies. This work uses a composite index of vulnerability that posits that the vulnerability index is a function of the exposure, sensitivity, and the adaptive capacity indexes. FAOSTAT and Yield Gap Atlas data were used for the period 1991-2016 to calculate the sensitivity index. The World Bank Climate Portal provided the mean annual growing season temperature data used to compute the exposure index. The World Bank, figshare, and MPR archives were used to capture the proxies of adaptive capacity such as literacy and poverty rates. These findings indicate that wheat has the lowest vulnerability index and the greatest adaptive capacity index, while barley has the strongest vulnerability and lowest adaptive capacity indexes. Sub-nationally, the indices of vulnerability and the standardized growing season's temperature decreased northwards. Northwards, wheat records the lowest vulnerability and highest adaptive capacity, and the second highest standard growing season temperature. In perspective, enhance adaptive capacity for climate resilience in policies, reduce vulnerability.
Discharge coefficient of vertical sluice gates with broad crested weir under free-submerged orifice flows using best subset regression
Authors: Cang Zhuoying , Jia Dongdong , Wang Jinyang , Yang Jun , Hao Youzhi , Chen Xiaona
Published: March 2024

Accurate calculation of flow discharge for sluice gates is essential in irrigation, water supply, and structure safety. The measurement of discharge with the requirement of distinguishing flow regimes is not conducive to application. In this study, a novel approach that considers both free and submerged flow was proposed. The energy–momentum method was employed to derive the coefficient of discharge. Subsequently, the discharge coefficient was determined through the experiment which was performed on the physical model of a vertical sluice gate with a broad-crested weir. Feature engineering, incorporating dimensional analysis, feature construction, and correlation-based selection were performed. The best subset regression method was employed to develop regression equations of the discharge coefficient with the generated features. The derived formula was applied to compute the discharge coefficient in the vertical sluice gate and determine the flow discharge. The accuracy of adopted method was assessed by comparing it with recent studies on submerged flow, and the results demonstrate that the developed approach achieves a high level of accuracy in calculating flow discharge. The coefficient of determination for the calculated flow rate is 0.993, and the root mean square percentage error is 5.04%.
Pollution sources apportionment and suitability assessment of Lah River, Ethiopia: Conjunctive application of multivariate statistical analysis and water quality index
Authors: Angello Zelalem Abera , Mengist Mentwabe Asiratu
Published: March 2024

This study aimed to assess spatiotemporal water quality variation and its suitability for irrigation and domestic purposes in Lah River using the irrigation water quality index (IWQI) and the weighted arithmetic water quality index (WAWQI). The IWQI analysis result showed that the sodium absorption ratio, residual sodium carbonate, potential salinity, Kelly index, magnesium ratio, sodium percentage, and permeability index were found to be 1.07 mEq/L, −0.43 mEq/L, 0.8 mEq/L, 0.78 mEq/L, 43.01%, 42.95%, and 63.46%, respectively. The IWQIs revealed that the water quality of the river was appropriate for agricultural use during the dry season. Furthermore, the calculated WAWQI of the river water ranged from 123.13 to 394.72 during the wet season, indicating the high pollution levels in the Lah River and incompatibility for drinking purposes. On the other hand, the principal component analysis identified two pollution sources during the wet season and three during the dry season. In addition, the positive matrix prioritization model predicted the pollution source's contribution quite well with a signal-to-noise ratio of >2 and a residual error between −3 and 3 for both seasons. This study suggests that water quality of Lah River is degrading periodically necessitating proper pollution management.
Recent Advances in Signaling Pathways and Kinase Inhibitors for
Leukemia Chemotherapy
Authors: Liu Yuying , Yang Zeyu , Zhang Qingqing , Hai Ping , Zheng Yongbiao , Zhang Jie , Pan Xiaoyan
Published: March 2024

Leukemia is a malignant clonal disease of hematopoietic stem cells, which accounts
for about 3% of the total incidence of tumors and is particularly prevalent among
children and adolescents. It mainly includes four types of leukemia, namely ALL, AML,
CLL, and CML, which are often aggressive and challenging diseases to treat. Several signaling
pathways are dysregulated in almost all types of leukemia, such as JAK, PI3K, and
MAPK, and others are dysregulated in specific types of leukemia, like Wnt/β-catenin,
Hedgehog, FLT3, Bcr-Abl, and so on. Many efforts have been devoted to developing
small molecule inhibitors targeting protein kinases involved in leukemia-related signaling
pathways. In this review, we focus on the study of signaling pathways and protein kinases
that developed as targets of anti-leukemia drug therapy and report the research progress of
relevant small molecule kinase inhibitors over the last five years.
Modulatory Role of Phytochemicals/Natural Products in Cancer
Immunotherapy
Authors: Vijayan Yadu , Sandhu Jaskirat Singh , Harikumar Kuzhuvelil B.
Published: March 2024

:

Immunotherapy is a newly emerging and effective approach to treating cancer.
However, there are many challenges associated with using checkpoint inhibitors in
this treatment strategy. The component of the tumor microenvironment plays a crucial
role in antitumor immune response, regulating tumor immune surveillance and immunological
evasion. Natural products/phytochemicals can modulate the tumor microenvironment
and function as immunomodulatory agents. In clinical settings, there is a strong
need to develop synergistic combination regimens using natural products that can effectively
enhance the therapeutic benefits of immune checkpoint inhibitors relative to their
effectiveness as single therapies. The review discusses immunotherapy, its side effects,
and a summary of evidence suggesting the use of natural products to modulate immune
checkpoint pathways.
Development and Validation of a Prognostic Model based on 11 E3-related
Genes for Colon Cancer Patients
Authors: JIang Wanju , Dong Jiaxing , Zhang Wenjia , Huang Zhiye , Guo Taohua , Zhang Kehui , Jiang Xiaohua , Du Tao
Published: March 2024

Background:

Colon cancer is a common tumor in the gastrointestinal tract with a poor prognosis.
According to research reports, ubiquitin-dependent modification systems have been found to play a crucial
role in the development and advancement of different types of malignant tumors, including colon cancer. However,
further investigation is required to fully understand the mechanism of ubiquitination in colon cancer.

Methods:

We collected the RNA expression matrix of the E3 ubiquitin ligase-related genes (E3RGs) from the
patients with colon adenocarcinoma (COAD) using The Cancer Genome Atlas program (TCGA). The “limma”
package was used to obtain differentially expressed E3RGs between COAD and adjacent normal tissues.
Then, univariate COX regression and least absolute shrinkage and selection operator (LASSO) analysis were
performed to construct the prognostic signature and nomogram model. Afterward, we used the original copy
number variation data of COAD to find potential somatic mutation and employed the “pRRophetic” package
to investigate the disparity in the effectiveness of chemotherapy drugs between high and low-risk groups. The
RT-qPCR was also implied to detect mRNA expression levels in tumor tissues.

Results:

A total of 137 differentially expressed E3RG3 were screened and 11 genes (CORO2B, KCTD9, RNF32,
BACH2, RBCK1, DPH7, WDR78, UCHL1, TRIM58, WDR72, and ZBTB18) were identified for the construction
of prognostic signatures. The Kaplan-Meier curve showed a worse prognosis for patients with high
risk both in the training and test cohorts (P = 1.037e-05, P = 5.704e-03), and the area under the curve (AUC)
was 0.728 and 0.892 in the training and test cohorts, respectively. Based on the stratified analysis, this 11-
E3RGs signature was a novel and attractive prognostic model independent of several clinicopathological parameters
(age, sex, stage, TNM) in COAD. The DEGs were subjected to GO and KEGG analysis, which identified
pathways associated with cancer progression. These pathways included the cAMP signaling pathway, calcium
signaling pathway, Wnt signaling pathway, signaling pathways regulating stem cell pluripotency, and
proteoglycans in cancer. Additionally, immune infiltration analysis revealed significant differences in the infiltration
of macrophages M0, T cells follicular helper, and plasma cells between the two groups.

Conclusion:

We developed a novel independent risk model consisting of 11 E3RGs and verified the effectiveness
of this model in test cohorts, providing important insights into survival prediction in COAD and several
promising targets for COAD therapy.
Phytochemicals for Cancer Treatment: An Update on Plant-Derived Anti-Cancer Compounds and their Mechanisms of Action
Authors: Ullah Sana , Khan Tariq , Khan Taimoor , Ali Muhammad , Khaliq Jan Abdul , Khan Shinwari Zabta , Khan Ajmal , Al-Farsi Mohamed , Waqas Muhammad
Published: March 2024

Cancer remains one of the major causes of morbidity and mortality worldwide. Scientists
from different fields are working to devise an efficient treatment strategy in order to reduce
the global burden of cancer. Commonly used treatment approaches for cancer treatment include
chemotherapy, immunotherapy, photodynamic therapy, radiation, surgery, etc. These treatment
procedures have several pitfalls, such as toxicity, limited bioavailability, rapid elimination, poor
specificity, and high cost. On the other side, plant-derived anticancer compounds exhibit several
advantages and can overcome these shortcomings. Plant-based anticancer compounds are safer, potent,
easily available, and comparatively cost-effective. The current review discusses pure plant-
based compounds that are used as a therapeutic remedy for anticancer application. The proposed
mechanisms of action, through which these compounds inhibit cancer cell growth, tumor growth,
angiogenesis, instigate apoptosis, cytotoxicity, mitochondrial membrane degradation, and reduce
cell viability as well as cell cycle progression, are also reviewed. These naturally occurring compounds
exhibit great therapeutic potential and could be used as candidate drugs in clinical applications.
Gallic Acid Derived 1, 2-Diarylindole as a Potential Antifungal Agent against Candida Strain
Authors: Kurmi Alka , Singh Akash Pratap , Gautam Yashveer , Singh Nandan , Tripathi Alok , Negi Arvind Singh , Gautam Hemant K. , Pal Anirban , Saikia Dharmendra
Published: March 2024

Background:

In recent decades, Candida albicans has become a serious issue for
public health. The worldwide rapid rise in drug resistance to conventional therapies is the main
contributing reason. Moreover, because of their potent activity at low concentrations and apparent
lack of toxicity, compounds originating from plants are used in therapeutic treatments because of
their potent activity at low concentrations and apparent lack of toxicity. Particularly in immunocompromised
people, Candida species can result in a wide range of ailments.

Objectives:

Present manuscript describes antifungal activity of an indole derivative 1-(4-((5-
methoxy-2-(3,4,5-trimethoxyphenyl)-1H-indol-1-yl) methyl) phenoxy)-N,N-dimethylethan-1-
amine (7, 100DL-6) by using an in-silico and in-vitro anti-candidal activity against two Candida
strains; Candida kefyr-DS-02 (ATCC-204093) and Candida albicans (AI-clinical isolate, AIIMS-
Delhi).

Methods:

The synthetic strategy for the preparation of indole derivatives was modified through
Fischer indole reaction. Antifungal activity of an indole derivative 1-(4-((5-methoxy-2-(3,4,5-
trimethoxyphenyl)-1H-indol-1-yl) methyl) phenoxy)-N,N-dimethylethan-1-amine (7, 100DL-6)
was done by using an in-silico and in-vitro anti-candidal activity against two Candida strains; Candida
kefyr-DS-02 (ATCC-204093) and Candida albicans (AI-clinical isolate, AIIMS-Delhi). Compound
100DL-6 efficacy was determined by Combination synergy study, ergosterol binding assay,
MTT toxicity study and Mutagenicity.

Results:

Compound 100DL-6 was obtained in 65% yield on desired motifs. Docking scores found
were 100DL-6 (-8.7 kcal/mol) and Fluconazole (-7.6 kcal/mol). Further, RMSD were shown for
100DL6 (0.26 ± 0.23 nm) and fluconazole (1.2 ± 0.62 nm). Indole derivative 100DL-6 was active
against the tested fungal pathogens and the total zone of inhibition was measured between 13-14
mm in diameter and MIC values between 31.25 μg/mL to 250 μg/mL and MFC values between
62.5 μg/mL to 500 μg/mL. In checkerboard assay synergistic mode of interaction of 100DL-6
with known antifungal drugs was observed. In the presence of ergosterol 100DL-6 and standard
drug (s) increased their MIC values, demonstrating a considerable affinity for ergosterol. Compound
100DL-6 was considered to be less-cytotoxic to the cells as determined by MTT assay.
Lead compound 100DL-6 was found to be non-mutagenic.

Conclusion:

In the present study, 100DL6 (indole derivatives) significantly abrupted the ergosterol
biosynthetic pathway and showed moderate anti-candidal effects. These studies suggest that
100DL6 significantly enhances antifungal effect of clinical drug fluconazole synergistically and
may be considered as in clinical trial prior to some extensive in-vivo validations.
Prospects of Repurposed Drugs in Diabetes Mellitus: A Current Update
Authors: Kalita Nihalini , Pathak Manash Pratim , Roy Siba , Barbhuiya Pervej Alom , Saikia Lunasmrita , Mazumder Tausif Mohammed Sanaur Rahman , Sen Saikat
Published: March 2024

Background:

Diabetes is a serious and chronic metabolic disorder that is a result of a
complex interaction of genetic and environmental factors. Diabetes mellitus has become a worldwide
pandemic. Drug discovery has been complicated by the high cost and time required for developing
new drugs/agents. In the last 30 years, the number of FDA-approved medications has declined, boosting
interest in drug repositioning or repurposing. Repurposing existing drugs may be a significant
tool for lowering the financial burden that most nations bear while treating diabetic mellitus.

Objective:

This comprehensive review aims to elucidate the repurposed pharmaceutical agents for
the treatment of Diabetes Mellitus along with the diverse array of validation techniques employed in
the process.

Methods:

For this review purpose, the authors have gone through a vast number of article sources
from various scientific databases like Google Scholar, PubMed, and Web of Science.

Results:

Drug repurposing led to the discovery of a few anti-diabetic drugs which has been widely
used for other pharmacological effects. Several medications, including celecoxib, buspirone, berberine,
diacerein, methazolamide, and bromocriptine, have been effective in treating diabetic mellitus
by various mechanisms like decreasing insulin resistance, hyperglycemia, inhibiting glucagon secretion
and improving insulin sensitivity.

Conclusion:

The field of drug repurposing exhibits significant potential in tackling the obstacles presented
by T2DM and other complex diseases. The conventional approaches to drug development have
often been characterized by prolonged durations and high costs, resulting in significant delays in the
discovery of effective medicines for conditions like T2DM. However, the strategy of drug repurposing
presents a more streamlined and economically advantageous method for drug development.
Sustainable Energy in Aviation with Reverse FMEA Analyses
Authors: Menyhárt József , Al-Aghbari N. G. E.
Published: March 2024

This research aims to identify and evaluate the key challenges and obstacles hindering the adoption of sustainable energy in the aviation industry. The outcomes and insights derived from this research will be synthesized to provide a comprehensive overview of the opportunities and suggestions for the adoption of sustainable energy in the aviation industry. The objective of this study is to help the aviation industry’s shift toward more sustainable energy sources in order to reduce its environmental footprint and mitigate the effects of climate change.
Dinamikai rendszer mozgásegyenletének felírása duális megközelítéssel
Authors: Rónai László
Published: March 2024

The paper deals with the description of a mathematical model of a mechanical system using the so-called energy-based approach. The model is created using both generalized displacements and generalized momenta. The latter prescription method is less common in practice, due to its complexity. The two ways are presented through the same example mechanical problem, and a control task is also solved with the help of a PID block.