bluuebunny/crossref_metadata_2025 huggingface dataset:
A Study Based on Controlled Drug Release by 3D Printed Aloe-Vera Bi-Layer Tablet
Authors: Verma Anurag , Mittal Piyush , S. Pande Milind , Trivedi Neelanchal
Published: October 2021

Aloe-Vera or Aloe barbadensis (botanical name) is a plant with many medicinal properties and have great importance in Ayurveda. Its leaves are succulent, erect, forming a thick rosette. The internal translucent pulp of Aloe-Vera is bound to a waxy crust or cuticle, and its vascular tissues transport minerals as well as water from the soil. Aloe Vera is being used as a major skin rejuvenating product, although it has varied medicinal properties also. In the present study, an attempt to make a method to create bi-layer tablets of Aloe-Vera, utilizing 3D printing techniques is presented. The method created doesnt affect the integral functional characteristics of the tablet. The method here contains creating an immediate release and sustained release tablet for making the Aloe-Vera to be used directly by the person for its numerous health effects. The tablet is designed so to be consumed by vegans as well since it is completely herbal.
Effectiveness of Kangaroo Mother Care in Weight Gain among Newborn Babies in AVBRH Hospitals of Wardha
Authors: Maurya Archana , Lakhakar B. , Kurian Bibin , Besekar Switi
Published: October 2021

Introduction: Kangaroo Mother Care is a simple and feasible intervention; acceptable to most mothers admitted in hospitals. There may be benefits in terms of reducing the incidence of hypothermia with no adverse effects of Kangaroo Mother Care. Kangaroo Care infants showed improvement in regular breathing patterns and virtually no periodic breathing, weight gain in low birth babies, suggesting  that Kangaroo Mother Care is safe for these infants.

Materials and Methods: Randomized control trai, l  experimental and control group design was used in study this study was conducted in post natal wards of AVBR Hospital. In this study samples were newborns that were fulfilling the inclusion and exclusion criteria. 500 newborns were selected and it was equally divided into two groups as control 250 and experimental 250. Random sampling technique was used in this study. A checklist regarding the frequency and duration of KMC was prepared for the experimental group. 

Results: The mean weight gain in the control group at birth is 2.71, on discharge it is 2.53 and on follow up it is 3.07. The mean weight gain in the experimental group at birth is 2.74, on discharge it is 2.67 and on follow up it is 3.31. 

Conclusion: Significant difference was found in the mean weight gain between experimental and control group. Thus it is concluded that KMC is effective in increasing the weight of the newborn babies.
A Case Report of Complete Heart Block
Authors: Dhobe Sonal , Singh Seema , Sharma Ranjana , Ankar Ruchira
Published: October 2021

Introduction: Complete Heart Block (CHB) occurs when the electrical signals can’t pass normally from the atria, the heart’s upper chambers, to the ventricles or lower chambers. This condition can develop because of congenital or secondary to cancers, myopathies or heart ischemia, infectious or endocrinological disorders and it needs comprehensive work-up to be excluded.

Background: In the United States, the prevalence of third degree atrioventricular (AV) block that is  complete heart block is 0.02 percent.  The prevalence of third-degree AV blocks worldwide is 0.04 percent. With advancing age, the rate of AV conduction defects rises, resembling the age-related incidence of ischemic heart disease.

Case Presentation: A case of 68 year old female admitted in cardiac ward on date 11 january 2021 with the chief complaint of breathlessness on exertion, restlessness, chest pain and loss of appetite since 2 month. The patient is a known case of hypertension since 5 year, Ischemic heart disease sine 1 year. after physical examination and other investigation like ECG, electrocardiogram the  she diagnosed as a complete heart block with third degree.

Interventions: The patient was treated by placing permanent pacemaker on dated 18 january 2021. After that started the antibiotic like inj. targocid, inj. ceftriaxone, tab. linezolid, tab. orabest, tab. telmed H  and taking  also the anticoagulant therapy. She also under the care of cardiologists and monitor by hourly, also monitor the electric activity of pacemaker. Provide health education about healthy diet, life style modification, yoga and exercised, control over blood pressure and regular follow up.

Conclusion: This study mainly focusing on the medical and placement of permanent pacemaker which help the heart to do their normal function and passing a normal electrical signals throught the heart rhythm. A good nursing care needed for the patient who have complete heart block and surgical implementation in permanent pacemaker  for continue monitored, no any complication can occur during or after pacemaker implantation. the patient response for the treatment was good and she recover rapidly.
Airway Management in COVID- 19 Patients
Authors: Dhobe Sonal , Ankar Ruchira , Dhanvijay Roshani , Dighikar Vrushali , Thakre Pratiksha
Published: October 2021

The first case found in 31 December 2019 in China, in Wuhan city but China reported this news to WHO in January 2020 after this corona virus can spread worldwide, and WHO declare this disease as a pandemic. As per survey now over the 4,444,670 cases of Covid-19 can identified in 188 countries globally and 1,588,858 can recovery rate of this disease worldwide.  Corona virus can caused by Severe Acute Respiratory Syndrome-Corona Virus-2 (SARS-CoV-2), is a single standard ribonucleic acid that enclose to corona virus and it is very infectious and spreading all over the world. It can be transmitted or spreading by droplets and come to direct contact with the patients compare to airborne spread. There is no any specific treatment strategy for corona virus, only supportive therapies such as respiratory care to the severe or acute patients, it’s especially in severe condition.

Aim is to provide airway management to COVID 19 patients and what is the role of airway management in this patient condition. This can provide issues with the person who severely suffering from respiratory diseases in hospital settings. The COVID 19 predominantly causing infection like pneumonia. At the time of giving intervention for managing the patient with severe respiratory condition are managed by mainly tracheal intubation and forming a controlled ventilation. As far this disease condition can increase, there will be the many community people are not having any symptoms of COVID 19 but after few days or week, they showing symptoms. Then they patients come under the emergency services.
Overview on Regulatory Requirements for Medical Devices in Srilanka - National Medicines Regulatory Authority/NMRA
Authors: Motupalli Vishakharaju , Bose Subhash Chandra , Venkatesh M. P. , Tiwari Varsha , Ramya Gembali
Published: October 2021

In the health-care industry, medical devices are becoming increasingly significant. One of the most challenging aspects of developing and manufacturing medical devices is keeping up with regulatory regulations and incorporating them into the process Registration, licensing, manufacture, importation, and all other elements of medical devices shall be regulated and controlled by the National Medicines Regulatory Authority in accordance with the National Medicines Policy. In this article we discuss about regulatory overview and registration of medical devices in Sri Lanka. A “medical device,” as defined by the Act, is any instrument, apparatus, appliance, software, material, or other article, whether used alone or in combination, that is used in or on humans for the purposes of:  Diagnosis, prevention, monitoring, treatment, or alleviation of disease; Anatomy or physiological process investigation, replacement, or alteration, Conception control. Any change in product information should be reported to the NMRA as soon as possible during the evaluation process and after product registration, especially if it involves rejection/withdrawal, additional data on product quality, effectiveness, or safety, or the manufacturers' current Good Manufacturing Practice (cGMP) compliance. The sample license will be produced in three copies, each of which will be valid for one year from the date of issue, and will be available for pick-up at the reception point. (An extra copy of the dossier will be included).
O caso de Dandara dos Santos: sobre a violência e o corpo dissidente
Authors: Souza de Melo George
Published: October 2021

Este texto coloca em análise a violência contra travestis e transexuais, a partir da mescla de vieses históricos, filosóficos e a realidade brasileira. Fundamentalmente, faz uso de contribuições teóricas, tais como: o corpo enquanto instrumento do dispositivo de biopoder; violência ética; transexualidade. Estas categorias representam um aporte fundamental para a compreensão da transexualidade, sua história e realidade na vida social. No entanto, para uma relação direta com a realidade, foram utilizados os relatos sobre a trágica experiência do assassinato de Dandara do Santos, travesti cearense, brutalmente executado [o assassinato] num bairro da periferia de Fortaleza, capital do estado. A relação entre esses dois campos de análise possibilita uma elucidação teórico-filosófica do tipo de violência que faz do Brasil o país mais mata pessoas transexuais e travestis do mundo. O trabalho, desta forma, objetivou desenvolver uma contribuição de fundamentação que leve à consciência da relação intrínseca entre teoria e prática como um importante e necessário elo entre a universidade e o ativismo social.
Gordura que não sai - Análise dos discursos de ódio nas redes a partir da interação com imagens da performance gordura trans #3/ gordura localizada #1, de Miro Spinelli
Authors: Riscado Caio Arnizaut
Published: October 2021

O artigo analisa os discursos de ódio propagados por usuários das redes sociais a partir de interações com registros da performance gordura trans #3 / gordura localizada #1, de Miro Spinelli, realizada em Salvador (BA). O estudo descreve os memes preconceituosos e criminosos produzidos com a utilização ilegal da imagem do artista e analisa os comentários difamatórios realizados sobre ele e o seu trabalho em arte. Através desses exemplos, o artigo relata como esses discursos incitam a discriminação e a violência contra pessoas desviantes por meio de mensagens transfóbicas, gordofóbicas e patologizantes. Além disso, torna evidente as experiências de linchamento e condenação virtuais sofridas pela população LGBTQ+.
A (re)execução de Marielle Franco a partir das lentes de O Globo no Twitter
Authors: Silveira-Barbosa Paula , Melani Rocha Paula
Published: October 2021

A execução da vereadora Marielle Franco e de Anderson Pedro Gomes comoveu o país pela brutalidade, violação dos direitos humanos e afrontamento aos movimentos sociais. A repercussão ultrapassou as fronteiras geográficas do Brasil. Além das ruas, as redes sociais também foram canais das manifestações. No entanto, o espaço ainda foi usado para veicular discursos de ódio, homofóbicos, misóginos, racistas e difundir "notícias falsas" sobre a vereadora. A reflexão discute a cobertura do jornal O Globo sobre o caso Marielle Franco. O objetivo é detalhar os sentidos atribuídos ao crime e seus desdobramentos, a partir das publicações de O Globo no Twitter. Observou-se por meio da análise do discurso francesa cinco dias de postagens, somando 29 tweets. Verificou-se a tentativa do periódico de despolitizar a execução da vereadora, assim como o silenciamento em torno da difusão de informações falsas sobre a parlamentar.
Denúncia sobre o assassinato de Gisberta Salce em Indulgência Plenária de Alberto Pimenta
Authors: De Jesus Tiago Correia
Published: October 2021

No ano de 2006, a transexual Gisberta Salce Júnior foi assassinada na cidade do Porto/Portugal, após ser torturada, humilhada e abusada sexualmente, durante três dias, por um grupo de rapazes, entre 12 e 16 anos, internos de uma oficina de acolhimento vinculada à Igreja Católica. Depois de considera-la morta, eles lançaram o corpo de Gisberta em um poço, acreditando que ela não pudesse ser facilmente encontrada. Porém, após a confissão de um dos garotos para uma professora da oficina, as autoridades policiais portuguesas tomarem ciência do ato. No relatório pericial da autopsia, considerou-se que a morte da Gisberta se deveu a água, e não aos sofrimentos vividos durante os três dias em que foi torturada pelo grupo de rapazes. Mais tarde, em julgamento junto ao Ministério Público português, os agressores foram inocentados, uma vez que a culpa da morte de Gisberta foi transferida para a água. Indignada, parte da sociedade portuguesa com a comunidade LGBTQ+, saíram às ruas para protestar por um novo julgamento. Além de reivindicar a criação da primeira lei contra crimes de ódio contra a diversidade sexual e de gênero. Neste mesmo momento, o poeta português Alberto Pimenta, publica o livro-poema, Indulgência Plenária (2013), em que leio como uma homenagem à Gisberta e denúncia ao Estado Português. Diante disso, pretendo refletir acerca da representação da denúncia contra a conclusão do julgamento no livro-poema de PIMENTA (2013), com base em AGAMBEN com O que resta de auschwitz? (2014), e na pergunta de BUTLER, “quando a vida é passível de luto? ”, realizada em Quadros de Guerra (2017).
Pânico moral, homofobia e discurso de ódio em um blog na Internet.
Authors: Carvalho Karla Jordana de Moraes , Lionço Tatiana
Published: October 2021

Homossexuais tem sido alvo de discursos de ódio na Internet. Este artigo faz uma análise qualitativa dos discursos de legitimação da homofobia em um blog. Tem como objetivo identificar os argumentos adotados nos discursos de ódio, categorizando analiticamente a base empírica. A metodologia utilizadas foi a Teoria Fundamentada. Pôde-se concluir que a principal estratégia discursiva do autor é o agenciamento do pânico moral , que se operacionaliza por meio de (1) associação da homossexualidade a crimes (entre casais homossexuais, pedofilia, assassinatos e outros crimes hediondos); e (2) inferiorização e desqualificação moral da homossexualidade (apresentando-a como um risco social a ser combatido, pois é uma ameaça a crianças adotivas, aos próprios homossexuais, a toda a sociedade e à humanidade). Conclui-se que, apesar de ser difícil tipificar o discurso de ódio, tais narrativas levam à aversão contra homossexuais, e contrariamente a outros conteúdos expressados na internet a partir da presunção do anonimato, o posicionamento do autor como cristão talvez seja o fator que o legitime a se autorizar moralmente ao ódio justificado.
Performatizações dissidentes na escola: masculinidades precárias em discussão
Authors: Brito Leandro Teofilo de , Couto Junior Dilton Ribeiro
Published: October 2021

Este trabalho se propôs a problematizar sentidos das masculinidades dissidentes às normas regulatórias de gênero na escola. Para isso, analisamos trechos de duas entrevistas estabelecidas com jovens adolescentes autoproclamados gays, estudantes do ensino médio de instituições públicas do Rio de Janeiro. A pesquisa foi fundamentada teoricamente pelas contribuições da filósofa feminista Judith Butler, através das noções de performatividade e precariedade, além dos estudos de gênero em articulação com o campo da Educação. Nos apropriamos da noção de entrevista narrativa de Leonor Arfuch, do conceito de experiência de Joan Scott e das teorizações de Mikhail Bakhtin sobre dialogismo e alteridade para pensar, teórico e metodologicamente, a produção de conhecimento realizada em parceria com os entrevistados. Ao analisar performatizações dissidentes, concluímos para a urgente necessidade de (re)construirmos novos modos de (re-)existência que contribuam com o enfrentamento dos diversos tipos de violência no espaço escolar, objetivando transformar as experiências dissidentes em aprendizados coletivos que nos afetem e que possam afetar os/as outros/as.
Quando a pedagogia toma posição ou o que aprendemos diante das imagens dos homens do triângulo rosa?
Authors: Balthazar Gregory da Silva
Published: October 2021

Inspirado em Berlot Brecht, problematizarei, com o presente texto, o lugar da imagem na construção de uma pedagogia que toma posição, isto é, um processo de aprendizagem pela imagem que nos provoca a criar linhas de resistência às sombras do autoritarismo de nosso tempo. Com efeito, proponho uma análise do filme Bent de Sean Mathias (1997), em dois movimentos metodológicos fundamentais: o lugar das imagens na luta pela memória das dores dos homens do triângulo rosa sob o nazismo e, inseparável disso, o gesto ético que estas imagens nos demandam assumir hoje.
Travestilidade em foco: análise dos marcadores de gênero, sexualidade e raça a partir de denúncias de violência.
Authors: Andrade Vinicius Novais Gonçalves de , Borges Lenise Santana
Published: October 2021

Resumo: Este artigo tem por objetivo propor reflexões sobre os discursos que constroem o corpo travesti quando interseccionado pelos marcadores sociais de sexualidade e raça. Trata-se de uma investigação documental, com delineamento qualitativo e que tem suas bases na interdisciplinaridade dos estudos da Psicologia Socioconstrucionista, queer e feministas. São analisados os trechos narrativos de violência presentes nas denúncias recebidas pelo Disque Direitos Humanos — módulo LGBT, ano de 2014 — de uma travesti brasileira: negra e homossexual. Tais reflexões partem do método da arqueologia do saber de Michel Foucault.  Os resultados da pesquisa mostraram que, a partir das narrativas denunciativas, as violências possuem motivos específicos relacionados a identidade de gênero travesti, a identidade sexual homossexual e a raça negra com objetivo de humilhar, subalternizar e diminuir a existência da referida travesti. Conclui-se que os corpos não normativos, do ponto de vista dos diferentes marcadores sociais, são constantemente alvo de violências.Palavras-chave: Psicologia Construcionista Social; Denúncias; Violência; Travesti.
Fazendo gênero, fazendo enunciados: discursos sobre a homofobia na escola
Authors: Da Rosa Marcelo Victor , Osório Antônio Carlos do Nascimento , Prado Filho Kleber , Passamani Guilherme Rodrigues
Published: October 2021

Esta pesquisa tem por objetivo investigar os enunciados que formam discursos científicos sobre a temática da homofobia particularmente na educação escolarizada, a partir da análise dos trabalhos completos publicados no Seminário Internacional Fazendo Gênero. A pesquisa teve como ferramentas princípios teóricos e metodológicos foucaultianos. A partir do lançamento do Programa Federal Brasil sem Homofobia, que ocorreu em maio de 2004, a homofobia passou a se configurar como uma problemática, ganhando visibilidade neste campo discursivo. Localizamos no campo estudado a produção de embate de posições epistemológicas opostas ao uso e o não uso dos enunciados de opção sexual/orientação sexual, tolerância e bullying.
Vozes alienígenas: Viagem de um homem trans do século XX na estética dos cantores emasculados (castrati)
Authors: Botteghi Egon
Published: October 2021

Por vontade de Sisto V, no final do século XVI, as mulheres foram proibidas de se apresentarem nas peças teatrais e, em Territórios Eclesiásticos, de cantar durante as funções litúrgicas. Por quase três séculos, a cena do “belcanto” italiano foi dominada pelos cantores castrati, homens cisgêneros que foram castrados antes da voz mudar, com a finalidade de manter sua capacidade de cantar com um registro agudo, compensando a falta de mulheres nos palcos e nas igrejas. Embora nessa prática não houvesse a vontade de criar um terceiro sexo, o grande sucesso desses cantores, além das inquestionáveis habilidades vocais, estava fortemente ligado à perturbação de gênero que causavam na plateia. Neste artigo, por meio de meu olhar particular de homem transexual, ativista, erudito e cantor pelo prazer (amador) do repertório barroco, procuro expor os pontos de convergência entre o uso da voz e dos corpos dos cantores castrati e o dos transexuais de nosso tempo, para refletir sobre algumas questões de gênero na música, também, para trazer a reflexão para quem hoje acredita que eles são os herdeiros desses artistas quase mitológicos.
Memórias do enclausuramento: presas políticas, gênero e clausura (1968-1979)
Authors: Norek Ayssa Yamaguti
Published: October 2021

Na Ditadura Civil-Militar, as mulheres tiveram papel significativo. Insurgiram contra esse regime enquanto agentes políticos ao lado dos homens. A historiografia tem tentado, pouco a pouco, mapear a participação dessas mulheres na militância – que envolve o movimento estudantil e as organizações de luta armada –, as graves violações de direitos humanos aos quais foram submetidas nos centros de repressão, seu papel na Justiça de Transição e até mesmo tem trazido à tona histórias de vida entrecruzadas nestes temas. Mas ainda há uma lacuna nos estudos sobre os presídios que receberam essas mulheres na condição de presas políticas e no percurso sinuoso feito por elas dentro dos meandros da repressão, até chegarem, enfim, a esses locais. Pretendemos, portanto, contribuir nestes estudos a partir da análise deste caminho e, principalmente, da sua experiência dentro dos presídios Instituto Penal Talavera Bruce (no Rio de Janeiro) e Tiradentes (em São Paulo), sob um viés de gênero.
“Podem duas mulheres falar sobre masculinidades?”: entre saberes localizados e a reflexão sobre múltiplas masculinidades // “Can two women talk about masculinities?”: Between situated knowledge and reflection on multiple masculinities
Authors: Oliveira Isabela Venturoza de , Sousa Fernanda Kalianny Martins
Published: October 2021

Este artigo se propõe, a partir de um ponto de vista feminista crítico negro e interseccional, tecer algumas considerações sobre o impacto, desconfianças e questionamentos que surgiram quando duas mulheres se propuseram a ministrar um curso de férias intitulado "Introdução aos estudos de masculinidades". A partir da descrição da turma, dos nossos objetivos enquanto docente, da nossa localização enquanto pesquisadoras e sujeitos, iremos abordar as noções que os e as estudantes tinham quando se matricularam no curso ou quando faziam suas falas no espaço das aulas. Para tanto, começaremos nos localizando enquanto sujeitos e pesquisadoras, bem como o trabalhos que temos desenvolvido nos últimos cinco anos; posteriormente, traremos uma descrição de quem eram os e as estudantes e o que havia levado cada um deles e delas até ali; traçaremos, em seguida, uma breve retomada histórica dos estudos de masculinidades, explicando quais foram os caminhos que decidimos percorrer e como fizemos nossas escolhas de autores e autoras para compor o curso; após analisar exercício de escrita feito pelos estudantes no último dia de aula, nós teceremos algumas considerações que buscarão conectar os diferentes pontos abordados no decorrer do artigo. Como considerações importantes a serem feitas é crucial apontarmos o autoflagelo e a dificuldade que as e os educandos tinham quando precisavam falar de situações que entendiam não fazer parte de seus "lugares de fala". Buscando não ignorar, mas tentando não esvaziar significativos debates contemporâneos sobre lugar de fala, representatividade e protagonismo, construíremos no artigo a necessidade de saída do autoflagelo, do congelamento dos debates e a importância de nos pautarmos por debates feitos dialogicamente e a partir de locais múltiplos.
Masculinidades trans: sobre alegorías, performatividades y subversiones a las cisheteronormas // Trans masculinities: on allegories, performativities and subversions of cis -heteronorms
Authors: Caravaca-Morera Jaime Alonso , Padilha Maria Itayra
Published: October 2021

Pensar y reflexionar sobre las masculinidades hodiernas latinoamericanas implica inexorablemente problematizar la supuesta obviedad que dicta una linealidad entre hombres y expresiones de género primitivas. En este espacio reflexivo objetivamos transitar entre los caminos paradójicos de respuestas existenciales para develar la conceptualización plural de masculinidades trans. La masculinidad trans debe ser comprendida como un proceso ilimitado que tiene sus orígenes en las relaciones de las fuerzas sociales con la subjetividad intrínseca del ser (humano). Además, sus desdoblamientos advienen del conocimiento de sí y de otras instituciones sociales. Complementariamente, se dibuja como una institución total en la que se ejerce el poder disciplinario por medio de la (des)aplicación de normas. Esta aplicación proviene tanto de otros, mediante las prácticas disciplinarias de las personas con las que interactúan los hombres trans, y de ellos mismos, cuando se dedican a la autodisciplina. Al tomar la conceptualización de la masculinidad trans, concluimos que en general este constructo de poder oscila entre el polo de la alienación que oprime individuos y repite la subjetividad exactamente como la recibe y el polo de la creación y singularización que se presenta como posibilidad de expresión y creatividad en que la persona se reapropia de su subjetividad
la cortadura
Authors: Rivera Raquel Salas
Published: October 2021

Raquel Salas Rivera
SHAKESPEARE’S COMIC AND TRAGIC GENDER ISSUES: AN ATTEMPT AT TRANSGRESSION IN THE TAMING OF THE SHREW (1591) AND ROMEO & JULIET (1597)
Authors: Gonçalves Davi
Published: October 2021

This article analyses Shakespeare’s literary discourse as an integral factor among the society wherein it was inserted. The overall context of my study is this precise dialogue between the literary structure and the structure of society. The symptoms that I allege literary texts tend to display are crucial for the effective functioning of the narratives herein analysed, and which consist thus in the specific context of my study. Such context consists in Shakespeare’s plays The Taming of the Shrew (1591) and Romeo & Juliet (1597), whose readings focus here specifically on the main characters of both narratives’ attempt at transgressing social borders. The comic and the tragic are not opposed, they are not poles apart in terms of meaning, effects, importance, and structure – in fact, in many occasions tragedy depends on comic stances and vice versa. My findings demonstrate how the frontiers dividing tragedy and comedy are not as concrete as it may seem – and trying to insert them within closed epistemological boxes might be detrimental for any fruitful reading of them. Shakespeare’s main characters in both plays might be read as a historical token of women’s unsuccessful endeavor to defeat repression.
Transviando cidades: O relatar a si mesmo e a construção de uma memória queer no curta-metragem "Virgindade"
Authors: Rodrigues Marques Henrique
Published: October 2021

Graças aos avanços e a popularização dos meios de captação audiovisual que aconteceram nas últimas décadas, a produção de documentários em primeira pessoa apresentou lato crescimento nos últimos anos. Por seu caráter egocêntrico centrado na vida pessoal de seus realizadores, esse tipo de filme é constantemente alvo de acusações e deslegitimação. Mas não pode o relato em primeira pessoa transcender a experiência individual? Seriam esses filmes necessariamente narcisistas e supérfluos? Falar de si mesmo é político? Partindo de algumas reflexões sobre o filme-ensaio e o documentário em primeira pessoa, esse artigo se propõe a fazer uma análise do curta-metragem brasileiro Virgindade (Chico Lacerda, 2015). Pretende-se assim apontar como o uso estrutural da obra fílmica produz um discurso que constrói uma certa memória utópica queer, como proposta por José Esteban Muñoz.
O Cissexismo como uma norma não escrita da psicanálise (Ou: para que serve o gênero à clínica?)
Authors: Stona Jose , Ferrari Andrea
Published: October 2021

O artigo, em um primeiro momento, tem por objetivo discutir historicamente o conceito de cissexismo. Em um segundo momento, visa a demonstrar como esse conceito pode se transformar em uma regra não escrita da teoria psicanalítica freudiana se o analista não estiver atento às demandas da clínica e à cultura de seu tempo. Neste artigo, justifica-se que os estudos de gênero são ferramentas clínicas de arejamento teórico para que os psicanalistas não cometam atitudes normativas, violentas e estigmatizantes na clínica.
Novel Bilayer Microarray Patch‐Assisted Long‐Acting Micro‐Depot Cabotegravir Intradermal Delivery for HIV Pre‐Exposure Prophylaxis
Authors: Tekko Ismaiel A. , Vora Lalitkumar K. , Volpe‐Zanutto Fabiana , Moffatt Kurtis , Jarrahian Courtney , McCarthy Helen O. , Donnelly Ryan F.
Published: October 2021

Injectable long‐acting cabotegravir (CAB LA) is effective and safe for pre‐exposure HIV prophylaxis. It is recently approved for clinical use in those at high risk of contracting HIV. However, injections are invasive and access to trained healthcare personnel to administer CAB LA can be limited, especially in low‐income countries (LICs). Herein, for the first time, the development of a bilayer microarray patch (MAP) with unique design and novel formulation as a potential alternative self‐administrated intradermal delivery system for CAB is reported. The novel MAP has a high drug load (≈3 mg/0.5 cm2 of CAB LA or its micronized sodium salt) and fast‐dissolving tips (<30 min) and shows good mechanical properties and skin insertion capabilities. Importantly, in preclinical in vivo studies using Sprague Dawley rats, this MAP is able to implant the drug‐loaded tips in the skin, forming micro‐depots. Both drug forms are then released in a sustained manner, maintaining human therapeutic levels in the rats for one month after a single application. Weekly repeated MAP dosing in the rats showed the MAPs to be reproducible and well‐tolerated. This bilayer MAP presents a promising minimally‐invasive, self‐administered, alternative delivery system for CAB for enhanced HIV prevention, especially in LICs.
4D Pixel Mechanical Metamaterials with Programmable and Reconfigurable Properties
Authors: Xin Xiaozhou , Liu Liwu , Liu Yanju , Leng Jinsong
Published: October 2021

The tension‐torsion coupling metamaterial (TTCM) exhibits torsional deformation while stretching, with the degree of freedom exceeding the Cauchy elasticity. However, the TTCM suffers from the limitations of the weak tension‐torsion coupling effect (TTCE), narrow deformation domain, and lack of adaptability. To address these limitations, mechanical pixel (MP) array design, helical microstructure, and 4D printing are introduced into the TTCM in this study, providing new strategies to exploit the deformation potential of the TTCM. The developed MP exhibits the tunability, programmability, and reconfigurability of the mechanical behaviors (stress–strain relationship, TTCE). The pixel mechanical metamaterial (PMM) with uncoupled deformation between MPs is obtained, which greatly enriches the design diversity of configurations and maintainability. The application prospects of the developed PMM for information encryptions, kinematics controllers, soft robots, and buffer devices are demonstrated. More interestingly, an egg falling on the PMM at the height of ≈1 m remains intact due to the excellent protection performance of the PMM.
Interplay of Structure, Charge‐Carrier Localization and Dynamics in Copper‐Silver‐Bismuth‐Halide Semiconductors
Authors: Buizza Leonardo R. V. , Sansom Harry C. , Wright Adam D. , Ulatowski Aleksander M. , Johnston Michael B. , Snaith Henry J. , Herz Laura M.
Published: October 2021

Silver‐bismuth based semiconductors represent a promising new class of materials for optoelectronic applications because of their high stability, all‐inorganic composition, and advantageous optoelectronic properties. In this study, charge‐carrier dynamics and transport properties are investigated across five compositions along the AgBiI4–CuI solid solution line (stoichiometry Cu4x(AgBi)1−xI4). The presence of a close‐packed iodide sublattice is found to provide a good backbone for general semiconducting properties across all of these materials, whose optoelectronic properties are found to improve markedly with increasing copper content, which enhances photoluminescence intensity and charge‐carrier transport. Photoluminescence and photoexcitation‐energy‐dependent terahertz photoconductivity measurements reveal that this enhanced charge‐carrier transport derives from reduced cation disorder and improved electronic connectivity owing to the presence of Cu+. Further, increased Cu+ content enhances the band curvature around the valence band maximum, resulting in lower charge‐carrier effective masses, reduced exciton binding energies, and higher mobilities. Finally, ultrafast charge‐carrier localization is observed upon pulsed photoexcitation across all compositions investigated, lowering the charge‐carrier mobility and leading to Langevin‐like bimolecular recombination. This process is concluded to be intrinsically linked to the presence of silver and bismuth, and strategies to tailor or mitigate the effect are proposed and discussed.
A Structured Phase Change Material with Controllable Thermoconductive Highways Enables Unparalleled Electricity via Solar‐Thermal‐Electric Conversion
Authors: Zhang Yongzheng , Wu Kai , Fu Qiang
Published: October 2021

A solar thermoelectric generator (STEG) that harvests solar energy and converts it into electricity based on the fundamentals of the Seebeck effect is a promising alternative to photovoltaic technologies. The combination of a phase change material (PCM) with STEG further enables stable and durable energy output despite the variations of solar radiation flux. However, the widespread promotion of STEG is still impeded by its restricted output electricity (<50 W m−2), attributed to the undesirable thermal management in PCMs. Herein, an ingenious phase change composite, with the typical conformation of circular truncated cone and embedded with the actinomorphic arrangement of polybenzobisoxazole fibers, is tailored by a mold processing strategy. The fibrous crystals in organic fibers offer temperature‐resistance thermal highways during the charging/discharging processes, while their actinomorphic configuration facilitates a controllable thermo‐conductive behavior. These structural features render concentrated thermal energy to be efficiently stored in the PCM and maximally discharged into the thermoelectric system. A record‐breaking power density as high as 198.70 W m−2 can be achieved in this powerful STEG via real‐environment solar‐thermal‐electric conversion, a value comparable to that of some commercial photovoltaic devices. This work opens up opportunities for durable and giant electricity supply from clean solar energy during real‐time STEG applications.
An Approach to Quantify the Negative Capacitance Features in a Triple‐Cation based Perovskite Solar Cells
Authors: Dhifaoui Hassen , Hemasiri Naveen Harindu , Aloui Walid , Bouazizi Abdelaziz , Kazim Samrana , Ahmad Shahzada
Published: October 2021

Understanding the device kinetics occurring in the bulk and at the charge selective interfaces is vital for optimizing the performance of perovskite solar cells (PSCs) and their development. Planar PSCs are studied with and without hole transport layer (HTL) and power conversion efficiency of 16.23% is measured with poly(3‐hexylthiophene) [P3HT] as HTL, while the PSCs without HTL show significant hysteresis. A comprehensive electrical response of the PSCs is investigated. The bias‐dependent electrochemical impedance spectroscopy (EIS) reveals the appearance of the negative capacitance in the low‐frequency regime. The modification of the low‐frequency PSCs response accompanied by a further decrease in recombination resistance is due to the interfacial interactions between the migrating ions and the metal contact. The doped and undoped P3HT layers impede this interaction which explains the absence of the negative capacitance at lower applied voltages. The investigation provides an understanding of the physical processes behind the negative capacitance.
Dielectric Metasurfaces for Complete Control of Phase, Amplitude, and Polarization
Authors: Wu Tong , Zhang Xueqian , Xu Quan , Plum Eric , Chen Kaiji , Xu Yuehong , Lu Yongchang , Zhang Huifang , Zhang Ziying , Chen Xieyu , Ren Guanhua , Niu Li , Tian Zhen , Han Jiaguang , Zhang Weili
Published: October 2021

The achievable functionalities of metasurfaces are mainly determined by the capability of their unit cells to control the local electromagnetic responses. To realize full control over light, it is highly desired to find a kind of unit cell that can achieve complete control of the phase, amplitude, and polarization, which remains a big challenge and cannot be fully replaced with iteration algorithms. Here, such control is achieved by exploiting interference in a dielectric unit cell composed of multiple meta‐atoms, namely, a meta‐molecule. This strategy provides sufficient effective geometric degrees of freedom within the meta‐molecule to enable full control over its optical properties, as is demonstrated here with a complete meta‐molecule database. As a proof‐of‐concept demonstration, polarization‐independent, polarization‐dependent, and vectorial meta‐holograms are proposed and experimentally characterized. High imaging quality is achieved in both the measured intensity and phase distributions. This is allowed by the ability of the meta‐molecules to fully record the information of the target images. This strategy opens a direct way toward optical devices with various desirable functionalities.
DNA Aptamer–Cyanine Complexes as Generic Colorimetric Small‐Molecule Sensors
Authors: Alkhamis Obtin , Canoura Juan , Bukhryakov Konstantin V. , Tarifa Anamary , DeCaprio Anthony P. , Xiao Yi
Published: October 2021

Aptamers are promising biorecognition elements for sensors. However, aptamer‐based assays often lack the requisite levels of sensitivity and/or selectivity because they typically employ structure‐switching aptamers with attenuated affinity and/or utilize reporters that require aptamer labeling or which are susceptible to false positives. Dye‐displacement assays offer a label‐free, sensitive means for overcoming these issues, wherein target binding liberates a dye that is complexed with the aptamer, producing an optical readout. However, broad utilization of these assays has been limited. Here, we demonstrate a rational approach to develop colorimetric cyanine dye‐displacement assays that can be broadly applied to DNA aptamers regardless of their structure, sequence, affinity, or the physicochemical properties of their targets. Our approach should accelerate the development of mix‐and‐measure assays that could be applied for diverse analytical applications.
Dynamischer Austausch von Substituenten in einem präbiotischen Organokatalysator: Erste Schritte auf dem Weg zu einem evolutionären System
Authors: Closs Anna C. , Bechtel Maximilian , Trapp Oliver
Published: October 2021

Alle evolutionsbiologischen Prozesse führen zu einer Veränderung der vererbbaren Merkmale über nachfolgende Generationen hinweg. Die in der DNA kodierte genetische Information wird durch Mutation der Basensequenz verändert, selektiert und vererbt. Während dies auf der biologischen Ebene gut verstanden wird, ist eine evolutionäre Veränderung auf der molekularen Ebene kleiner organischer Moleküle unbekannt, stellt aber eine wichtige Voraussetzung für die Entstehung von Leben dar. In dieser Arbeit stellen wir eine Klasse von präbiotischen Imidazolidin‐4‐thion‐Organokatalysatoren vor, die ihre Zusammensetzung dynamisch ändern können und möglicherweise in der Lage sind, ein evolutionäres System zu bilden. Diese Katalysatoren funktionalisieren ihre Bausteine und passen sich durch Mutation ihrer eigenen Struktur dynamisch an ihre (selbst modifizierte) Umgebung an. Abhängig von den Umgebungsbedingungen zeigen sie eine ausgeprägte und gegensätzliche Selektivität bei ihrer Bildung. Bemerkenswerterweise können die bevorzugt gebildeten Spezies mit unterschiedlichen katalytischen Eigenschaften verbunden sein, die mehrere Wege für den Übergang von abiotischer Materie zu funktionellen Biomolekülen ermöglichen.
Visible Light Induced Brønsted Acid Assisted Pd‐Catalyzed Alkyl Heck Reaction of Diazo Compounds and N‐Tosylhydrazones
Authors: Zhang Ziyan , Kvasovs Nikita , Dubrovina Anastasiia , Gevorgyan Vladimir
Published: October 2021

A mild visible light‐induced palladium‐catalyzed alkyl Heck reaction of diazo compounds and N‐tosylhydrazones is reported. A broad range of vinyl arenes and heteroarenes with high functional group tolerance, as well as a range of different diazo compounds, can efficiently undergo this transformation. This method features Brønsted acid‐assisted generation of hybrid palladium C(sp3)‐centered radical intermediate, which allowed for new selective C−H functionalization protocol.
Synthesis of (±)‐Setigerumine I: Biosynthetic Origins of the Elusive Racemic Papaveraceae Isoxazolidine Alkaloids**
Authors: Serna Ana V. , Kürti László , Siitonen Juha H.
Published: October 2021

The biosynthetic origins of the structurally related racemic isoxazolidine Papaveraceae alkaloids Setigerumine I, Dactylicapnosinine and Dactylicapnosine have remained elusive since their original isolation over two decades ago. Herein we report the first biosynthetic hypothesis for their formation and, inspired by it, the first synthesis of (±)‐Setigerumine I with accompanying computational rationale. Based on the results, these isoxazolidine alkaloids arise from racemizing oxidative rearrangements of prominent isoquinoline alkaloids Noscapine and Hydrastine. The key steps featured in this synthesis are a room temperature Cope elimination and a domino oxidation/inverse‐electron demand 1,3‐dipolar cycloaddition of an axially chiral, yet configurationally unstable, intermediate. The work opens this previously inaccessible family of natural products for biological studies.
Enhancement of SNAr reactions by CH3SO3− ionic liquid and organic solvent dimethylformamide as bifunctional organocatalysts: A mechanistic study
Authors: Oh Young‐Ho , Lee Sungyul
Published: October 2021

Quantum chemical analysis is presented for the mechanism of SNAr reaction of p‐fluoronitrobenzene and p‐anisidine promoted by [C4C1im][CH3SO3] and by dimethylformamide (DMF), experimentally observed by Welton and co‐workers (Org. Lett. 2007, 9, 5247–5250). We find that [C4C1im]+ assists the detachment of the fluoride leaving group, while [CH3SO3]− supplies partial negative charge to the nucleophile NH2 to enhance the reactivity. We also show the moderate yield (22.1%) in DMF can also be understood by considering the solvent molecule as a bifunctional organocatalyst. The calculated Gibbs free energies of activation are in excellent agreement with the experimental observations.
Tuning Ruthenium Carbene Complexes for Selective P−H Activation through Metal‐Ligand Cooperation
Authors: Feichtner Kai‐Stephan , Scharf Lennart T. , Scherpf Thorsten , Mallick Bert , Boysen Nils , Gessner Viktoria H.
Published: October 2021

The use of iminophosphoryl‐tethered ruthenium carbene complexes to activate secondary phosphine P−H bonds is reported. Complexes of type [(p‐cymene)‐RuC(SO2Ph)(PPh2NR)] (with R = SiMe3 or 4‐C6H4−NO2) were found to exhibit different reactivities depending on the electronics of the applied phosphine and the substituent at the iminophosphoryl moiety. Hence, the electron‐rich silyl‐substituted complex undergoes cyclometallation or shift of the imine moiety after cooperative activation of the P−H bond across the M=C linkage, depending on the electronics of the applied phosphine. Deuteration experiments and computational studies proved that cyclometallation is initiated by the activation process at the M=C bond and triggered by the high electron density at the metal in the phosphido intermediates. Consistently, replacement of the trimethylsilyl (TMS) group by the electron‐withdrawing 4‐nitrophenyl substituent allowed the selective cooperative P−H activation to form stable activation products.
Resound Trial: A phase 2 study of regorafenib in patients with thymoma (type B2‐B3) and thymic carcinoma previously treated with chemotherapy
Authors: Perrino Matteo , De Pas Tommaso , Bozzarelli Silvia , Giordano Laura , De Vincenzo Fabio , Conforti Fabio , Digiacomo Nunzio , Cordua Nadia , D'Antonio Federica , Borea Federica , Santoro Armando , Zucali Paolo Andrea
Published: October 2021

Background

Angiogenesis has an important role in thymic epithelial tumors (TETs). Regorafenib inhibits vascular endothelial growth factor receptors (VEGFRs), platelet‐derived growth factor receptor β (PDGFR‐β), and fibroblast growth factor receptors (FGFRs). This study explored the activity of regorafenib as monotherapy in patients with advanced or recurrent B2‐B3 thymoma (T) and thymic carcinoma (TC) previously treated with platinum‐containing chemotherapy.

Methods

A Fleming single‐arm, single‐stage, phase 2 trial to evaluate the activity of regorafenib (160 mg once a day by mouth for 3 weeks on/1 week off) was planned. The study was designed to reject the null hypothesis of an 8‐week progression‐free survival (PFS) rate ≤25% with a type I error of 0.10 and a statistical power of 80% at the alternative hypothesis of an 8‐week PFS rate of ≥50% (≥8 of 19 evaluable patients progression‐free at 2 months).

Results

From June 2016 to November 2017, 19 patients were enrolled (11T/8TC). We observed partial response (PR) in 1 patient (1T) (5.3%), stable disease (SD) in 14 patients (9T/5TC) (73.7%), and progressive disease in 2 patients (1T/1TC) (10.5%), with a disease control rate of 78.9%. According to Choi‐criteria, 13 patients (68.4%) achieved PR, and 2 patients SD (10.5%). The median PFS was 9.6 months whereas median overall survival was 33.8 months. The 8‐week PFS rate was 78.9% (15 of 19 patients). Grade 3‐4 treatment‐related adverse events were observed in 10 patients (52.6%).

Conclusions

The primary end point of this study was reached. The high rate of PR (Choi‐criteria) suggests antitumor activity of regorafenib in TETs. On the basis of survival outcomes, the efficacy of regorafenib should be further evaluated in larger studies.
Biologics update: IL‐23 inhibitors
Authors: Hong Julie , Hadeler Edward , Mosca Megan , Chung Mimi , Yeroushalmi Samuel , Hakimi Marwa , Liao Wilson , Bhutani Tina
Published: October 2021

Introduction

IL‐23 inhibitors have shown long‐term efficacy and safety for the treatment of moderate‐to‐severe plaque psoriasis in adults. Guselkumab has also been approved to treat psoriatic arthritis while tildrakizumab and risankizumab are currently under investigation for treating psoriatic arthritis. The goal of this paper is to review and highlight the most current benefits and potential adverse events of IL‐23 inhibitors for psoriasis treatment.

Methods

A literature search was performed using the MEDLINE (PubMed), Embase, PsycINFO, and Web of Science databases. Only Phase III and Phase IV clinical studies were reviewed for the purpose of this paper.

Results

Clinical studies have shown IL‐23 inhibitors demonstrate superior efficacy compared to IL‐12/23 inhibitors and TNF‐a inhibitors. Adverse events with IL‐23 inhibitors are minimal, and the most common side effect is increased risk of infection.

Conclusion

Tildrakizumab, risankizumab, and guselkumab are IL‐23 inhibitors that are approved for the treatment of moderate‐to‐severe psoriasis. Multiple head‐to‐head trials have demonstrated long‐term efficacy and safety of IL‐23 inhibitors, compared to IL‐17 inhibitors, which have demonstrated short‐term efficacy.