bluuebunny/crossref_metadata_2025 huggingface dataset:
The effects of BDNF rs6265 and FGF21 rs11665896 polymorphisms on alcohol use disorder-related impulsivity in Han Chinese adults
Authors: Yang Shizhuo , Wang Fan , Sun Lanrong , Liu Xinqian , Li Siyuan , Chen Yingjie , Chen Lingling , Pan Zeheng , Kang Yimin , Chen Yu-Hsin , Wang Wei , Chen Li , Li Xiaokun , Tang Chonghui , Liu Yanlong
Published: April 2024

Introduction

Patients with alcohol use disorder (AUD) often experience repeated withdrawal. Impulsivity is the most relevant factor influencing successful withdrawal. Brain-derived neurotrophic factor (BNDF) and fibroblast growth factor 21 (FGF21) are associated with impulsivity. Previous studies on the differential effects of BDNF or FGF21 on impulsivity have focused on single-gene effects and have inconsistent results. We aim to investigate the effects of BDNF rs6265 and FGF21 rs11665896, individually and together, on impulsivity during alcohol withdrawal in patients with AUD.

Methods

We recruited 482 adult Han Chinese males with AUD and assessed their impulsivity using the Barratt Impulsivity Scale. Genomic DNA was extracted and genotyped from peripheral blood samples. Statistical analysis was conducted on the data.

Results

The T-test and 2 × 2 analysis of variance were used to investigate the effects of the genes on impulsivity. There was a significant BDNF × FGF21 interaction on no-planning impulsiveness (F = 9.15, p = 0.003, η2p = 0.03). Simple main effects analyses and planned comparisons showed that BDNF rs6265 A allele × FGF21 rs11665896 T allele was associated with higher no-planning impulsiveness. Finally, hierarchical regression analyses revealed that only the interaction of BDNF and FGF21 accounted for a significant portion of the variance in no-planning impulsiveness.

Conclusion and significance

The combination of BDNF rs6265 A allele and FGF21 rs11665896 T allele may increase impulsivity and discourage alcohol withdrawal. Our study provides a possible genetic explanation for the effects of associated impulsivity in patients with AUD from the perspective of gene-gene interactions.
Assessing the patient’s affective perception of their psychotherapist: validation of the in-Session Patient Affective Reactions Questionnaire
Authors: Stefana Alberto , Fusar-Poli Paolo , Vieta Eduard , Youngstrom Eric A.
Published: April 2024

Background

Psychotherapists need effective tools to monitor changes in the patient’s affective perception of the therapist and the therapeutic relationship during sessions to tailor therapeutic interventions and improve treatment outcomes. This study aims to evaluate the factor structure, reliability, and validity of the in-Session Patient Affective Reactions Questionnaire (SPARQ), a concise self-report measure designed for practical application in real-world psychotherapy settings.

Methods

Validation data was gathered from (N = 700) adult patients in individual psychotherapy. These patients completed the SPARQ in conjunction with additional measures capturing sociodemographic details, characteristics of therapeutic interventions, individual personality traits, mental health symptom severity, elements of the therapeutic relationship, and session outcomes. This comprehensive approach was employed to assess the construct and criterion-related validity of the SPARQ.

Results

The SPARQ has a two-factor structure: Positive Affect (k = 4, ω total = .87) and Negative Affect (k = 4, ω total = .75). Bifactor confirmatory factor analysis (CFA) yielded the following fit indices: X2[df] = 2.53, CFI = .99; TLI = .98; RMSEA = .05; and SRMR = .02. Multi-group CFAs demonstrated measurement invariance (i) across patients who attended psychotherapy sessions in person versus in remote mode, and (ii) across patients with and without psychiatric diagnoses confirmed metric invariance. Furthermore, the SPARQ showed meaningful correlations with concurrently administered measures.

Discussion

The SPARQ proves to be a valuable instrument in clinical, training, and research contexts, adept at capturing patients’ session-level affective responses towards their therapist and perceptions of the therapeutic alliance. Comprehensive descriptive statistics and a range of score precision indices have been reported, intended to serve as benchmarks for future research.
A containerised approach for multiform robotic applications
Authors: Cotugno Giuseppe , Rodrigues Rafael Afonso , Deacon Graham , Konstantinova Jelizaveta
Published: April 2024

As the area of robotics achieves promising results, there is an increasing need to scale robotic software architectures towards real-world domains. Traditionally, robotic architectures are integrated using common frameworks, such as ROS. Therefore, systems with a uniform structure are produced, making it difficult to integrate third party contributions. Virtualisation technologies can simplify the problem, but their use is uncommon in robotics and general integration procedures are still missing. This paper proposes and evaluates a containerised approach for designing and integrating multiform robotic architectures. Our approach aims at augmenting preexisting architectures by including third party contributions. The integration complexity and computational performance of our approach is benchmarked on the EU H2020 SecondHands robotic architecture. Results demonstrate that our approach grants simplicity and flexibility of setup when compared to a non-virtualised version. The computational overhead of using our approach is negligible as resources were optimally exploited.
Oral anaerobe bacteria—a common risk for cardiovascular disease and mortality and some forms of cancer?
Authors: Lund Håheim Anne Lise
Published: April 2024

This review explores the results of research on oral health concerning cardiovascular diseases and some forms of cancer and is based on results from published systematic reviews and some studies. The research results will have a strong focus on exploring the relationship between different aspects of oral infections. The relationship between oral health parameters, cardiovascular diseases (CVD), and certain cancers was examined from different angles, including prospective analyses, in a population-based health study in Oslo from the year 2000 (Oslo II study). A major finding was that low levels of antibodies to the oral anaerobe Tannerella forsythia predict both CVD mortality in men with a history of myocardial infarction and incidence of bladder cancer in a random sample of men in the study. Low levels of antibodies to Treponea denticola predict the incidence of bladder and colon cancer in a random sample of men in the study. Both anaerobe bacteria are part of the so-called red complex of bacteria in chronic periodontitis together with Pophyromonas gingivalis. These three bacteria have different properties and are causal in chronic periodontitis. They migrate into the local tissues by adhering to the oral epithelium, break down soft and hard tissues, and spread via the circulation to organs distant from the mouth. This paper will give an overview of which oral health measures have been explored and associated with different CVD and cancer diagnoses and what scientific literature supports or contravenes our hypothesis. The oral microbiome is described with the most relevant bacteria related to microbiology, serum, autopsies, and associated causes such as alcohol. There will be a mention of the possibilities and limitations of different study designs. There seems to be a causal relationship between oral anaerobe bacteria and systemic diseases regulated by the immune system. This is seen alongside other well-known risk factors, especially for CVD. The prospective finding of a relation to the incidence of certain cancers and CVD is particularly intriguing. However, further research is needed to determine the biological mechanisms underpinning these associations.
Assessing the circularity status of waste management among manufacturing, waste management, and recycling companies in Kigali, Rwanda
Authors: Mulindwa Mike Ssempa , Akor Jackson , Auta Mary , Nijman-Ross Elke , Ogutu Moses Onyango
Published: April 2024

A high quantity of waste is generated from industrial activities by manufacturers across metropolitan cities compared to smaller cities with fewer industrial activities. Adopting Circular Economy principles in waste management has the potential for sustainable waste management to reduce the quantity of waste at dumpsites and harmful emissions from wastes. The study was conducted to assess circularity status and challenges for attaining higher circularity by Kigali’s manufacturing, waste collection, and waste recycling companies using the 10-R framework. The study also sought to build estimates for industrial solid waste quantity and methane emissions for the next 10 years (2020–2030) in Rwanda. A mixed method approach was utilized where primary data was collected from manufacturing, waste collection, and waste recycling companies using a validated questionnaire and an in-depth interview guide. Thematic, descriptive analysis and First Order Decay methods were used to analyze the qualitative, quantitative, and secondary data. Results show that adopting the 10-R principles of circular economy was low and varies across manufacturing, waste collection and recycling companies. There were instances of high adoption of R3-Reuse and R8-Recycle with a mean score of 7.17 and 7.21 among manufacturing companies. R7-Repurpose (8.80) recorded a high adoption rate among waste collection companies and a medium level of adoption for R7-Repurpose (3.50) and R9-Recover (3.00) among recycling companies. The overall low adoption toward attaining circularity was attributed to various economic, institutional, infrastructural, operational, attitudinal, and technological challenges. In 2030, it is projected that 922 Gg of industrial waste will be deposited in solid waste disposal sites in Rwanda; with an estimated methane emission of 157 Gg Carbon dioxide equivalence. It was recommended among others, that human resource capacity development should be prioritized to drive the adoption of the 10-R principles across manufacturing, waste collection, and waste recycling companies in Kigali, which can reduce the quantity of wastes that ends at dumpsites and methane emissions that contribute significantly to global warming.
Foreign market entry with circular business models: a customer-centric approach
Authors: Yurdaanik Eskiyerli Devrim , Ewertz Simon
Published: April 2024

Circular business models have been developed in recent years, driven by concerns over environmental sustainability. The circular business models are initially tested domestically, but businesses may aspire to expand internationally with it. However, entering foreign markets with circular business models, which include novel products and innovative services, may be challenging. Moreover, generalized foreign market entry criteria for circular business models are lacking. This in-depth case study utilized a mixed-method approach to shed light on the tactical adaptations businesses need to make in their circular business model when entering foreign markets while also ensuring economic competitiveness. The case includes foreign market entry with a circular “service" business model; therefore, we emphasized the customer side of the business model canvas related to customer relationships. In our conclusion, we identify five tactical adaptations, namely implementing a co-creation tool for customization, offering tangible customized benefits, increasing investment in social media marketing, utilizing start-up incubators/accelerators/co-working spaces as a marketing channel and offering adjustable contract lengths. Foreign markets with circular business models and involving the value network partners of the business are also expected to expand the positive externalities of circular economy internationally.
Vermifiltration and sustainable agriculture: unveiling the soil health-boosting potential of liquid waste vermicompost
Authors: Malal Halima , Romero Veronica Suarez , Horwath William R. , Dore Sabina , Beckett Patrick , Ait Hamza Mohamed , Lakhtar Hicham , Lazcano Cristina
Published: April 2024

Vermifiltration is a promising technique that can help recover nutrients from wastewater for further use in agriculture. We conducted a field experiment to assess the effectiveness of vermicompost produced from the vermifiltration of liquid waste (manure and food production waste) and how it can affect the soil health and yield of a squash crop. We tested the effect of three rates of vermicompost (low, medium, and high) applied over two consecutive years and measured physical, chemical, and biological soil health indicators, squash yield, and nutritional status. The results showed that the use of vermicompost, especially at a high rate, increased total soil carbon, total nitrogen, potentially mineralizable nitrogen, and particulate organic matter, as well as the activity of C-N-P cycling enzymes, as compared to a control with only inorganic fertilization. The yield of the squash crop remained stable, while the crop nutritional value improved as the levels of boron and copper in the treated squash increased. These findings indicate an improvement in soil health after the use of vermicompost. Overall, results strongly support using this type of vermicompost as a sustainable management approach to recycle nutrients and enhance soil health.
Association of easy albumin-bilirubin score with increased mortality in adult trauma patients
Authors: Hsu Shiun-Yuan , Rau Cheng-Shyuan , Tsai Ching-Hua , Chou Sheng-En , Su Wei-Ti , Hsieh Ching-Hua
Published: April 2024

Introduction

The easy albumin-bilirubin (EZ-ALBI) score is calculated using the equation: total bilirubin (mg/dl) − 9 × albumin (g/dl), and is used to evaluate liver functional reserve. This study was designed to investigate whether the EZ-ALBI score serves as an independent risk factor for mortality and is useful for stratifying the mortality risk in adult trauma patients.

Methods

We retrospectively reviewed data from the registered trauma database of the hospital and included 3,637 adult trauma patients (1,241 deaths and 2,396 survivors) due to all trauma caused between January 1, 2009, and December 31, 2021. The patients were allocated to the two study groups based on the best EZ-ALBI cutoff point (EZ-ALBI = −28.5), which was determined based on the area under the receiver operating characteristic curve.

Results

Results revealed that the non-survivors had a significantly higher EZ-ALBI score than the survivors (−26.4 ± 6.5 vs. −31.5 ± 6.2, p < 0.001). Multivariate logistic regression analysis revealed that EZ-ALBI ≥ −28.5was an independent risk factor for mortality (odds ratio, 2.31; 95% confidence interval, 1.63–3.28; p < 0.001). Patients with an EZ-ALBI score ≥ −28.5 presented with 2.47-fold higher adjusted mortality rates than patients with an EZ-ALBI score < −28.5. A propensity score-matched pair cohort of 1,236 patients was developed to reduce baseline disparities in trauma mechanisms. The analysis showed that patients with an EZ-ALBI score ≥ −28.5 had a 4.12 times higher mortality rate compared to patients with an EZ-ALBI score < −28.5.

Conclusion

The EZ-ALBI score was a significant independent risk factor for mortality and can serve as a valuable tool for stratifying mortality risk in adult trauma patients by all trauma causes.
Quantitative assessment and objective improvement of the accuracy of neurosurgical planning through digital patient-specific 3D models
Authors: Hanalioglu Sahin , Gurses Muhammet Enes , Baylarov Baylar , Tunc Osman , Isikay Ilkay , Cagiltay Nergiz Ercil , Tatar Ilkan , Berker Mustafa
Published: April 2024

Objective

Neurosurgical patient-specific 3D models have been shown to facilitate learning, enhance planning skills and improve surgical results. However, there is limited data on the objective validation of these models. Here, we aim to investigate their potential for improving the accuracy of surgical planning process of the neurosurgery residents and their usage as a surgical planning skill assessment tool.

Methods

A patient-specific 3D digital model of parasagittal meningioma case was constructed. Participants were invited to plan the incision and craniotomy first after the conventional planning session with MRI, and then with 3D model. A feedback survey was performed at the end of the session. Quantitative metrics were used to assess the performance of the participants in a double-blind fashion.

Results

A total of 38 neurosurgical residents and interns participated in this study. For estimated tumor projection on scalp, percent tumor coverage increased (66.4 ± 26.2%–77.2 ± 17.4%, p = 0.026), excess coverage decreased (2,232 ± 1,322 mm2–1,662 ± 956 mm2, p = 0.019); and craniotomy margin deviation from acceptable the standard was reduced (57.3 ± 24.0 mm–47.2 ± 19.8 mm, p = 0.024) after training with 3D model. For linear skin incision, deviation from tumor epicenter significantly reduced from 16.3 ± 9.6 mm–8.3 ± 7.9 mm after training with 3D model only in residents (p = 0.02). The participants scored realism, performance, usefulness, and practicality of the digital 3D models very highly.

Conclusion

This study provides evidence that patient-specific digital 3D models can be used as educational materials to objectively improve the surgical planning accuracy of neurosurgical residents and to quantitatively assess their surgical planning skills through various surgical scenarios.
Optimizing the kidney donor pool: transplanting donor kidneys after partial nephrectomy of masses or cysts
Authors: Tabbara Marina M. , Riella Juliano , Gonzalez Javier , Gaynor Jeffrey J. , Guerra Giselle , Alvarez Angel , Ciancio Gaetano
Published: April 2024

Background

A limiting factor in expanding the kidney donor pool is donor kidneys with renal tumors or cysts. Partial nephrectomy (PN) to remove these lesions prior to transplantation may help optimize organ usage without recurrence of malignancy or increased risk of complications.

Methods

We retrospectively analyzed all recipients of a living or deceased donor graft between February 2009 and October 2022 in which a PN was performed prior to transplant due to the presence of one or more concerning growths. Donor and recipient demographics, perioperative data, donor allograft pathology, and recipient outcomes were obtained.

Results

Thirty-six recipients received a graft in which a PN was performed to remove suspicious masses or cysts prior to transplant. Majority of pathologies turned out to be a simple renal cyst (65%), followed by renal cell carcinoma (15%), benign multilocular cystic renal neoplasm (7.5%), angiomyolipoma (5%), benign renal tissue (5%), and papillary adenoma (2.5%). No renal malignancy recurrences were observed during the study period (median follow-up: 67.2 months). Fourteen complications occurred among 11 patients (30.6% overall) during the first 6mo post-transplant. Mean eGFR (± standard error) at 36 months post-transplant was 51.9 ± 4.2 ml/min/1.73 m2 (N = 23). Three death-censored graft losses and four deaths with a functioning graft and were observed.

Conclusion

PN of renal grafts with suspicious looking masses or cysts is a safe option to optimize organ usage and decrease the kidney non-use rate, with no observed recurrence of malignancy or increased risk of complications.
Diphtheria in a Swiss Asylum Seeker Reception Centre: Outbreak Investigation and Evaluation of Testing and Vaccination Strategies
Authors: Brockhaus Lisa , Urwyler Pascal , Leutwyler Ulrike , Würfel Eva , Kohns Vasconcelos Malte , Goldenberger Daniel , Keller Peter Michael , Tschudin Sutter Sarah , Labhardt Niklaus Daniel
Published: April 2024

Objectives: To describe a suspected diphtheria outbreak in a Swiss asylum seeker reception centre, and to analyse its management response regarding testing and vaccination.

Methods: We retrospectively analysed clinical, microbiology, and case management data of all asylum seekers tested for C. diphtheriae between 28th August and 31st December 2022 while residing at the centre. Results are reported descriptively.

Results: Among 265 individuals tested, ten cases of cutaneous diphtheria, one simultaneous respiratory and cutaneous case, and nine respiratory carriers were identified. Mass throat screening, targeted throat testing and targeted wound testing yielded 4.8%, 4.3%, and 17.4% positive results, respectively. No respiratory carrier was identified among cutaneous cases undergoing a throat swab, and no symptomatic case was identified among individuals with unspecific throat symptoms. Rates of vaccination implementation of newly arriving asylum seekers before and after the outbreak were low (17.5% and 15.5%, respectively), as were rates of targeted vaccination among cases and close contacts.

Conclusion: We provide evidence for transmission both prior to arrival and within the setting, suboptimal practices and timeliness of testing, and implementation gaps in vaccination.
An Oracle Bone Inscriptions Detection Algorithm Based on Improved YOLOv8
Authors: Zhen Qianqian , Wu Liang , Liu Guoying
Published: April 2024

Ancient Chinese characters known as oracle bone inscriptions (OBIs) were inscribed on turtle shells and animal bones, and they boast a rich history dating back over 3600 years. The detection of OBIs is one of the most basic tasks in OBI research. The current research aimed to determine the precise location of OBIs with rubbing images. Given the low clarity, severe noise, and cracks in oracle bone inscriptions, the mainstream networks within the realm of deep learning possess low detection accuracy on the OBI detection dataset. To address this issue, this study analyzed the significant research progress in oracle bone script detection both domestically and internationally. Then, based on the YOLOv8 algorithm, according to the characteristics of OBI rubbing images, the algorithm was improved accordingly. The proposed algorithm added a small target detection head, modified the loss function, and embedded a CBAM. The results show that the improved model achieves an F-measure of 84.3%, surpassing the baseline model by approximately 1.8%.
Comparison of Surface Ozone Variability in Mountainous Forest Areas and Lowland Urban Areas in Southeast China
Authors: Jiang Xue , Cheng Xugeng , Liu Jane , Chen Zhixiong , Wang Hong , Deng Huiying , Hu Jun , Jiang Yongcheng , Yang Mengmiao , Gai Chende , Cheng Zhiqiang
Published: April 2024

The ozone (O3) variations in southeast China are largely different between mountainous forest areas located inland, and lowland urban areas located near the coast. Here, we selected these two kinds of areas to compare their similarities and differences in surface O3 variability from diurnal to seasonal scales. Our results show that in comparison with the lowland urban areas (coastal areas), the mountainous forest areas (inland areas) are characterized with less human activates, lower precursor emissions, wetter and colder meteorological conditions, and denser vegetation covers. This can lead to lower chemical O3 production and higher O3 deposition rates in the inland areas. The annual mean of 8-h O3 maximum concentrations (MDA8 O3) in the inland areas are ~15 μg·m−3 (i.e. ~15%) lower than that in the coastal areas. The day-to-day variation in surface O3 in the two types of the areas is rather similar, with a correlation coefficient of 0.75 between them, suggesting similar influences on large scales, such as weather patterns, regional O3 transport, and background O3. Over 2016–2020, O3 concentrations in all the areas shows a trend of “rising and then falling”, with a peak in 2017 and 2018. Daily MDA8 O3 correlates with solar radiation most in the coastal areas, while in the inland areas, it is correlated with relative humidity most. Diurnally, during the morning, O3 concentrations in the inland areas increase faster than in the coastal areas in most seasons, mainly due to a faster increase in temperature and decrease in humidity. While in the evening, O3 concentrations decrease faster in the inland areas than in the coastal areas, mostly attributable to a higher titration effect in the inland areas. Seasonally, both areas share a double-peak variation in O3 concentrations, with two peaks in spring and autumn and two valleys in summer and winter. We found that the valley in summer is related to the summer Asian monsoon that induces large-scale convections bringing local O3 upward but blocking inflow of O3 downward, while the one in winter is due to low O3 production. The coastal areas experienced more exceedance days (~30 days per year) than inland areas (~5-10 days per year), with O3 sources largely from the northeast. Overall, the similarities and differences in O3 concentrations between inland and coastal areas in southeastern China are rather unique, reflecting the collective impact of geographic-related meteorology, O3 precursor emissions, and vegetation on surface O3 concentrations.
A Case Series Study of Weekly or Fortnightly Transcranial Magnetic Stimulation (TMS) in Major Depressive Disorder
Authors: Turnier-Shea Yvonne , Peterson Gregory M. , Rybak Marzena , Pridmore Saxby
Published: April 2024

Background: Major depressive disorder (MDD) is frequently chronic and relapsing. The use of maintenance or continuation transcranial magnetic stimulation (TMS) has received clinical and some research support. Objective: To conduct a case series study to report the outcomes of once-weekly (OW) or once-fortnightly (OF) continuation TMS in a real-life setting. Methods: We offered OW or OF TMS sessions to patients with MDD in remission or partial remission/relapse. Results: Ten patients received OW TMS and four received OF TMS, for 8 to 46 weeks. No patients in either group who were in remission or partial remission at baseline experienced a relapse. Improvements in HAMD6 and CGI-S scores were statistically significant or of borderline significance for the total sample and the OW group. Conclusions: This naturalistic, open-label observational study indicates that OW TMS is effective as maintenance therapy in MDD, while also offering some support for OF TMS maintenance in preventing relapse.
Durability of Ternary Blended Concrete Incorporating Rice Husk Ash and Calcined Clay
Authors: Marangu Joseph Mwiti , Sharma Meenakshi , Scheinherrová Lenka , Kafodya Innocent , Mutai Victor Kiptoo , Latif Eshrar , Novelli Viviana Iris , Ashish Deepankar Kumar , Maddalena Riccardo
Published: April 2024

Research on the combined substitution of supplementary cementitious materials (SCMs) has already demonstrated that it might be one of the few viable options to produce low-carbon concrete at scale. This paper presents an experimental investigation on the performance and durability of rice husk ash (RHA) and calcined clay (CC) in ternary blended concrete exposed to chloride attacks under wet/dry cycles. Portland cement (PC) was replaced by RHA and CC up to 50% by weight to produce low-carbon concrete. Samples were subjected to wet/dry cycles in 3.5% NaCl water, with mineralogical composition and microstructure development before and after exposure analysed by TGA-DSC, MIP, XRD, and SEM. The durability of the concrete against wet/dry cycles was investigated in terms of compressive strength, water absorption, open porosity, density, thermal conductivity, and electrical resistivity. The results showed that concrete mixes with CC and RHA up to 60% exhibited an increase of 33% in compressive strength, followed by minimal changes in water absorption. While a decrease in electrical resistivity was measured in all samples with RHA and CC, increasing the CC content to 50% resulted in improved resistance to chloride penetration. Increasing the CC content resulted in a more refined microstructure, with an overall decrease in porosity of up to 32% compared to the control series. While RHA alone did not contribute to significant improvements after wet/dry cycles, the combined substitution of RHA and CC at SCM replacement levels of 60% showed an overall improvement in hardened properties and durability. This investigation provides valuable insights into the long-term performance and strength of innovative low-carbon concrete.
Stability Analysis of Seismic Slope Based on Relative Residual Displacement Increment Method
Authors: Sun Weijian , Wang Guoxin , Ma Juntao
Published: April 2024

The seismic stability analysis of a slope is a complex process influenced by earthquake action characteristics and soil mechanical properties. This paper presents a novel seismic slope stability analysis method using the relative residual displacement increment method in combination with the strength reduction method (SRM) and the actual deformation characteristics of the slope. By calculating the relative displacement of the key point inside the landslide mass and the reference point outside the landslide mass after each reduction, the safety factor of the slope is determined by the strength reduction factor (SRF) corresponding to the maximum absolute value of the relative residual displacement increment that appears after a continuous plastic penetration zone. The method eliminates interference caused by significant displacement fluctuations of key points under earthquake action and reduces the subjective error that can occur when manually identifying displacement mutation points. The proposed method is validated by dynamic calculations of homogeneous and layered soil slopes and compared with three other criteria: applicability, accuracy, and stability.
Laparoscopic Treatment of Bulky Nodes in Primary and Recurrent Ovarian Cancer: Surgical Technique and Outcomes from Two Specialized Italian Centers
Authors: Daniele Alberto , Rosso Roberta , Ceccaroni Marcello , Roviglione Giovanni , D’Ancona Gianmarco , Peano Elisa , Clignon Valentino , Calandra Valerio , Puppo Andrea
Published: April 2024

(1) Background: Minimally invasive surgery (MIS) represents a feasible approach in early-stage ovarian cancer, while this question is still unsolved for advanced and recurrent disease. (2) Methods: In this retrospective, multicenter study, we present a series of 21 patients who underwent MIS for primitive or recurrent epithelial ovarian cancer (EOC) with bulky nodal metastasis and discuss surgical technique and outcomes in relation to the current literature. (3) Results: Complete cytoreduction at primary debulking surgery was obtained in 86% of cases. No complication occurred in our patients intraoperatively and only 11.1% of our patients experienced grade 2 and 3 postoperative complications. Notably, all the patients with isolated lymph nodal recurrence (ILNR) were successfully treated with a minimally invasive approach with no intra- or postoperative complications. (4) Conclusions: The results of our study are consistent with those reported in the literature, demonstrating that MIS may represent a safe approach in advanced and recurrent EOC with nodal metastasis if performed on selected patients by expert surgeons with an adequate setting and appropriate technique.
Evidence and Future Perspectives for Neoadjuvant Therapy for Resectable and Borderline Resectable Pancreatic Cancer: A Scoping Review
Authors: Endo Yutaka , Kitago Minoru , Kitagawa Yuko
Published: April 2024

Pancreatic cancer (PC) is a lethal disease that requires innovative therapeutic approaches to enhance the survival outcomes. Neoadjuvant treatment (NAT) has gained attention for resectable and borderline resectable PC, offering improved resection rates and enabling early intervention and patient selection. Several retrospective studies have validated its efficacy. However, previous studies have lacked intention-to-treat analyses and appropriate resectability classifications. Randomized comparative trials may help to enhance the clinical applicability of evidence. Therefore, after searching the MEDLINE database, this scoping review presents a comprehensive summary of the evidence from published (n = 14) and ongoing (n = 12) randomized Phase II and III trials. Diverse regimens and their outcomes were explored for both resectable and borderline resectable PC. While some trials have supported the efficacy of NAT, others have demonstrated no clear survival benefits for patients with resectable PC. The utility of NAT has been confirmed in patients with borderline resectable PC, but the optimal regimens remain debatable. Ongoing trials are investigating novel regimens, including immunotherapy, thereby highlighting the dynamic landscape of PC treatment. Studies should focus on biomarker identification, which may enable precision in oncology. Future endeavors aim to refine treatment strategies, guided by precision oncology.
Laryngeal Cancer Cells Metabolize 25-Hydroxyvitamin D3 and Respond to 24R,25-dihydroxyvitamin D3 via a Mechanism Dependent on Estrogen Receptor Levels
Authors: Dennis Cydney D. , Dillon Jonathan T. , Patel Prit H. , Cohen David J. , Halquist Matthew S. , Pearcy Adam C. , Boyan Barbara D. , Schwartz Zvi
Published: April 2024

Studies have evaluated vitamin D3’s therapeutic potential in estrogen-responsive cancers, with conflicting findings. We have shown that the proliferation of breast cancer cells is regulated by 24R,25-dihydroxyvitamin D3 (24R,25(OH)2D3) depending on estrogen receptor alpha 66 (ERα66) expression, suggesting that this could also be the case for estrogen-sensitive laryngeal cancer cells. Accordingly, we examined levels of ERα isoforms in ERα66-positive UM-SCC-12 and ERα66-negative UM-SCC-11A cells and their response to 24R,25(OH)2D3. 24R,25(OH)2D3 stimulated proliferation, increased the expression of metastatic markers, and inhibited apoptosis in UM-SCC-12 cells while having the opposite effect in UM-SCC-11A cells. To evaluate if vitamin metabolites could act via autocrine/paracrine mechanisms, we assessed the expression, protein levels, and activity of vitamin D3 hydroxylases CYP24A1 and CYP27B1. Both cell types expressed both mRNAs; but the levels of the enzymes and their activities were differentially regulated by estrogen. ERα66-negative UM-SCC-11A cells produced more 24,25(OH)2D3 than UM-SCC-12 cells, but comparable levels of 1,25(OH)2D3 when treated with 25(OH)D3 These results suggest that the regulation of vitamin D3 metabolism in laryngeal cancer cells is modulated by ERα66 expression, and support a role for 24R,25(OH)2D3 as an autocrine/paracrine regulator of laryngeal cancer. The local metabolism of 25(OH)D3 should be considered when determining the potential of vitamin D3 in laryngeal cancer.
Histological Patterns and Mammographic Presentation of Invasive Lobular Carcinoma Show No Obvious Associations
Authors: Cserni Gábor , Bori Rita , Ambrózay Éva , Serfőző Orsolya
Published: April 2024

Invasive lobular carcinoma of the breast has different mammographic appearances, including spiculated or lobulated masses, architectural distortion, increased breast density, and the possibility of also being occult. Histologically, the morphology is also variable, as several patterns have been described beside the classical one, including the solid, the alveolar, the trabecular, the one with tubular elements, and others. Of 146 ILC cases, 141 were reviewed for mammographic appearance and 136 for histological patterns by two radiologist and two pathologists, respectively; 132 common cases were analyzed for possible associations between mammographic presentation and the histological patterns. Interobserver agreement on the presence or absence of a given mammographic morphology ranged from 45% (increased density) to 95% (occult lesion); the most common radiomorphology was that of a spiculated mass. Interobserver agreement on the presence or absence of a given histological pattern ranged between 79% (solid) and 99% (classical) but was worse when semi-quantification was also included. The mammography–pathology correlation was less than optimal. Multifocality was more commonly detected by histology. The identification of a mammographic mass lesion often coincided with a mass-like lesion on the histological slides and vice versa, but nearly half of the mammographically occult lesions were felt to have masses on histological slides assessed grossly. Histological patterns showed no obvious associations with one or the other mammographic appearance.
An Initial Survey of Unionid Mussels in Lakes East of the Missouri River in South Dakota, USA
Authors: Henderson Riley E. , Wollman Katherine M. , Pasbrig Chelsey A. , Barnes Michael E.
Published: April 2024

This study surveyed freshwater mussels (family Unionidae) in 116 lakes and reservoirs east of the Missouri River in South Dakota, USA, during 2017. Using two-person–hour/site timed searches, evidence of a total of 1789 mussels, including 1053 live mussels, was obtained from 50 waters. Nine species, from two different orders, were found in lakes and reservoirs throughout five of the six major river drainages east of the Missouri River. The native species observed included Giant Floater Pyganodon grandis, Fatmucket Lampsilis siliquoidea, Threeridge Amblema plicata, White Heelsplitter Lasmigona complanata, Wabash Pigtoe Fusconaia flava, Deertoe Truncilla truncata, and Pink Heelsplitter Potamilus alatus. Giant Floater was the most widespread and abundant species observed, representing 63.3% of the live mussels sampled. Two non-native species, Zebra Mussel Dreissena polymorpha and Chinese Basket Clam Corbicula fluminea, were also documented from three water bodies in the lower Missouri River drainage. Overall, mussel abundance was negatively correlated with lake water conductivity and positively correlated with turbidity. No significant correlations were observed between species abundance and water temperature, pH, dissolved oxygen, or substrate particle size.
Too Warm and Too Dry—Decline and Threat of the Subarctic-Subalpine Liverwort Hygrobiella laxifolia in a Low Mountain Range in Central Europe under the Conditions of Climate Change
Authors: Müller Frank , Marková Ivana , Ritz Christiane M.
Published: April 2024

Using the liverwort Hygrobiella laxiflora as an example, this study aims to investigate the impact of climate change on montane species and their ecosystems. The study area is the Elbe Sandstone Mountains in Germany and the Czech Republic, where Hygrobiella laxifolia has an isolated occurrence in deeply carved gorges characterized by a specific microclimate (cellar climate). The focus is on determining the rate at which populations are affected. After little change in the population over a long period, a sudden sharp decline has been observed in recent years. The decline correlates with the mass proliferation of the European spruce bark beetle (Ips typographus) observed since 2017, which has led to a strong thinning of the forests in the area. In many areas of occurrence, the forests now have a much sparser tree layer or none at all. Competition from other, more competitive species also plays an important role as a cause of decline, as these have spread more widely on the sites due to the now higher light levels. The severe bark beetle infestation and the large-scale forest fire of 2022 both represent events that led to the almost complete deforestation of large parts of the study area, which was previously unknown on this scale. Since both the bark beetle infestation and the forest fire are strongly intensified by climate change, we assume that climate change is the main reason for the decline of Hygrobiella laxifolia in the area. The populations of Hygrobiella laxifolia of the Elbe Sandstone Mountains show some morphological peculiarities. As two new species have recently been described within Hygrobiella, we have integrated a sample from the area into a molecular phylogeny of Hygrobiella based on the plastid sequences of trnL-trnF intergenic spacer and matK to clarify the relationships. The sample from Elbe Sandstone Mountains fits well into the clade of Hygrobiella laxifolia.
Implications of Minimum Description Length for Adversarial Attack in Natural Language Processing
Authors: Tiwari Kshitiz , Zhang Lu
Published: April 2024

Investigating causality to establish novel criteria for training robust natural language processing (NLP) models is an active research area. However, current methods face various challenges such as the difficulties in identifying keyword lexicons and obtaining data from multiple labeled environments. In this paper, we study the problem of robust NLP from a complementary but different angle: we treat the behavior of an attack model as a complex causal mechanism and quantify its algorithmic information using the minimum description length (MDL) framework. Specifically, we use masked language modeling (MLM) to measure the “amount of effort” needed to transform from the original text to the altered text. Based on that, we develop techniques for judging whether a specified set of tokens has been altered by the attack, even in the absence of the original text data.
Investigation on Pollution-Induced Flashovers of In-Service Insulators in Ethiopian Power Transmission Lines
Authors: Desta Berhanu Zelalem , Wogari Mengesha M. , Gubanski Stanislaw M.
Published: April 2024

Power transmission lines in Ethiopia are experiencing an alarmingly high frequency of unexplained outages triggered by environmental factors, which significantly undermine the reliability of the country’s power system. This paper presents investigations aiming to identify those among the unexplained fault records that have been caused by pollution induced flashovers. An identification method is developed, which associates the contextual fault features, such as information about the characteristics of the fault, fault location, and time of day, as well as month of its occurrence with local meteorological/climatic and environmental conditions. A total number of 4231 unexplained faults, recorded between 2015 and 2022, were analyzed. Among them, 1045 faults (24.7%) were identified as being most likely caused by pollution induced flashovers. The entire network suffered from more than 130 pollution-induced flashovers annually with a frequency of about 0.8 faults/100 km/year. The fault frequency strongly differed among the grid regions, being highest in the Northeast and lowest in the Southwest region. Moreover, the performed analyses also concentrated on the evaluation of the pollution performance of various insulator types employed in the network. The results indicate that porcelain insulators have the highest pollution-induced flashover intensity of 1.47 faults/year/1000 units, followed by silicone rubber polymeric composite insulators and glass insulators with the respective intensities of 1.21 and 0.83 faults/year/1000 units. These results indicate that despite the high expectations towards the pollution performance of silicone rubber polymeric insulators, their use in the Ethiopian climatic and environmental conditions appears to be unsatisfactory.
Characteristics of Bacterial Communities under Different Tree Species and Their Response to Soil Physicochemical Properties
Authors: Chen Zhe , Li Suyan , Sun Xiangyang , He Libing , Zhou Wenzhi , Zhao Guanyu , Yu Jiantao , Bai Xueting , Zhang Jinshuo
Published: April 2024

This study investigates the structure of soil bacterial communities in the brown mountain soils beneath the deciduous broadleaf forests of Dongling Mountain and their response to soil physicochemical properties. Aiming to provide a scientific basis for soil conservation and sustainable forest development under deciduous broadleaf forests, this research utilized high-throughput sequencing technology to examine the diversity and community structure of bacteria in soil under different tree species, alongside assessing soil physicochemical properties. The results revealed significant differences in nutrient content between the 0–20 cm and 20–40 cm soil layers. Additionally, the N:P in the brown mountain soils of Dongling Mountain was found to be below the national average, indicating potential nitrogen limitation. Dominant bacterial phylum included Actinobacteria, Proteobacteria, and Acidobacteria. The study also found that soil bacterial community structure was similar under different tree species at the same depth but varied significantly with soil depth. Furthermore, redundancy analysis (RDA) showed that the available potassium (AK), total nitrogen (TN), and ammonium nitrogen (NH4+-N) significantly influenced the structural changes in the soil bacterial community. This research highlights the characteristics of soil bacterial community structure beneath deciduous broadleaf forests and its relationship with soil physicochemical properties, offering valuable insights for regional soil ecosystem conservation and forest management.
Drought Impact on Eco-Physiological Responses and Growth Performance of Healthy and Declining Pinus sylvestris L. Trees Growing in a Dry Area of Southern Poland
Authors: Benisiewicz Barbara , Pawełczyk Sławomira , Niccoli Francesco , Kabala Jerzy Piotr , Battipaglia Giovanna
Published: April 2024

In recent years, several drought events hit Poland, affecting its forests. In Opole, Poland, tons of Pinus sylvestris L. deadwood is removed every year due to drought. Understanding the physiological mechanisms underlying tree vulnerability to drought, and tree responses, is important to develop forest management strategies to face the ongoing climate change. This research provides comprehensive local-scale analyses of the sensitivity of healthy and declining trees to drought. We used dendrochronology and stable isotope analysis to compare five healthy and five declining trees. The analysis focused particularly on comparisons of basal area increment (BAI), δ13C, and intrinsic water-use efficiency (iWUE), as well as tree resistance, resilience, and recovery in response to drought events and sensitivity to selected meteorological parameters. We observed a significant reduction in BAI values in declining trees after 2000. Fifteen years later, the reduction was also visible in the iWUE values of these trees. Despite similar δ13C chronology patterns, declining trees showed higher δ13C correlations with meteorological parameters. We have shown that dendrochronology enables early detection of poor forest health conditions. Differences in iWUE chronologies occurring in recent years suggest that trees of both groups have chosen different adaptive strategies to cope with drought stress.
Response of Soil Fungal-Community Structure to Crop-Tree Thinning in Pinus massoniana Plantation
Authors: Lyu Qian , Yang Huiqin , Yin Biran , Xiang Yongqi , Zhao Kuangji , Hou Guirong , Chen Gang , Fan Chuan , Li Xianwei
Published: April 2024

To address the ecological challenges arising from pure forest plantations and the wood supply–demand imbalance, implementing sustainable forest management is paramount. Accordingly, we studied crop trees at three densities (100, 150, and 200 N/ha) in a subtropical Pinus massoniana plantation. Our study revealed that the dominant phyla and genera within the fungal community remained largely consistent, with Basidiomycota and Ascomycota occupying prominent positions. Notably, the β diversity of the fungal community exhibited significant changes. Ectomycorrhizal and saprophytic fungi emerged as crucial functional guilds, and crop-tree thinning contributed to increased complexity within the fungal network, with a prevalence of positive rather than negative correlations among genera. The significant roles played by Camphor plants and ferns were evident in the fungal networks. Additionally, under crop-tree thinning, plant diversity experienced a significant boost, fostering interactions with the fungal community. Herb diversity played a vital role in the fungal community, affecting it either directly or indirectly, by altering the content of total phosphorus or organic matter in the soil. This study underscores the relationship between undergrowth plants and soil fungal communities, offering a scientific basis for evaluating the sustainability of restoring inefficient forest-plantation ecosystems.