bluuebunny/crossref_metadata_2025 huggingface dataset:
An Ode to Testing, my first review
Authors: Gray Charles T.
Published: September 2023

To give you an idea of where I am in my R developer germination, I’d just started reading about testing when I received an email from @rOpenSci inviting me to review the weathercan package. Many of us in the R community feel like imposters when it comes to software development. In fact, as a statistician, it was a surprise to me when I was recently called a developer.
Unconf18 projects 3: jobstatus, motifator, QcodeR, opencv, trackmd
Authors: Salmon Maëlle
Published: September 2023

For day 3 of project recaps from this year’s unconf, here is an overview of the next five projects. Stay tuned for the last recap tomorrow. (Full set of project recaps: recap 1, recap 2, recap 3, recap 4.) In the spirit of exploration and experimentation at rOpenSci unconferences, these projects are not necessarily finished products or in scope for rOpenSci packages.
fulltext v1: text-mining scholarly works
Authors: Chamberlain Scott
Published: September 2023

The problem Text-mining - the art of answering questions by extracting patterns, data, etc. out of the published literature - is not easy. It’s made incredibly difficult because of publishers. It is a fact that the vast majority of publicly funded research across the globe is published in paywall journals.
changes: easy Git-based version control from R
Authors: Tóth Anikó B. , Golding Nick
Published: September 2023

Are you new to version control and always running into trouble with Git?Or are you a seasoned user, haunted by the traumas of learning Git and reliving them whilst trying to teach it to others?Yeah, us too. Git is a version control tool designed for software development, and it is extraordinarily powerful.
restez: Query GenBank locally
Authors: Bennett Dom
Published: September 2023

What is restez? R packages for interacting with the National Center for Biotechnology Information (NCBI) have, to-date, depended on API query calls via NCBI’s Entrez.For computational analyses that require the automated look-up of reams of biological sequence data, piecemeal querying via bandwith-limited requests is evidently not ideal.
Introducing Maëlle Salmon, rOpenSci’s new Research Software Engineer
Authors: Butland Stefanie , Chamberlain Scott , Salmon Maëlle
Published: September 2023

We’re very pleased to be introducing someone who needs no introduction in the R community.
A rentrez paper, and how to use the NCBI's new API keys
Authors: Winter David
Published: September 2023

I am happy to say that the latest issue of

The R Journal

includes a paperdescribing rentrez,the rOpenSci package for retrieving data from the National Center for Biotechnology Information(NCBI). The NCBI is one of the most important sources of biological data. The centreprovides access to information on 28 million scholarly articles through PubMed and 250million DNA sequences through GenBank.
ramlegacy: a package for RAM Legacy Database
Authors: Gupta Kshitiz , Boettiger Carl
Published: September 2023

Introduction ramlegacy is a new R package to download, cache and read in all the different versions of the RAM Legacy Stock Assessment Database, a public database containing stock assessment results of commercially exploited marine populations from around the world.
Xây dựng các điều kiện nhằm tiếp tục triển khai thi hành Hiến pháp năm 2013
Authors: Nguyễn Thu Trang
Published: September 2023

Hiến pháp nước Cộng hòa Xã hội chủ nghĩa Việt Nam được Quốc hội thông qua năm 2013thực sự là Hiến pháp của thời kỳ đổi mới toàn diện, đồng bộ về kinh tế và chính trị, đáp ứngyêu cầu xây dựng, bảo vệ, phát triển đất nước và hội nhập quốc tế trong thời kỳ mới. Đồngthời, Hiến pháp cũng đã thể hiện rõ và đầy đủ hơn bản chất dân chủ, tiến bộ của Nhà nướcvà chế độ ta trong thời kỳ quá độ tiến lên chủ nghĩa xã hội. Nhìn lại có thể thấy, qua gần 10năm triển khai thi hành Hiến pháp 2013 đã có nhiều tác động to lớn đến sự phát triển kinhtế - xã hội của đất nước. Tuy nhiên, quá trình thi hành Hiến pháp vẫn còn nhiều khó khăn,vướng mắc.
Nâng cao hiệu quả hoạt động lấy phiếu tín nhiệm, bỏ phiếu tín nhiệm của Quốc hội và Hội đồng nhân dân
Authors: Phan Khuyên
Published: September 2023

Quốc hội và Hội đồng nhân dân tiến hành hoạt động lấy phiếu tín nhiệm, bỏ phiếu tín nhiệmđối với chức danh do Quốc hội và Hội đồng nhân dân bầu hoặc phê chuẩn dựa trên các quy định về thẩm quyền của Quốc hội và Hội đồng nhân dân. Thực hiện lấy phiếu tín nhiệm, bỏ phiếu tín nhiệm đã mang lại kết quả tích cực, góp phần vào việc thực hiện tốt chức nănggiám sát của Quốc hội và Hội đồng nhân dân. Tuy nhiên, hoạt động này vẫn còn những khókhăn, thách thức nhất định. Bài viết đề xuất một số kiến nghị nhằm tiếp tục nâng cao hiệuquả hoạt động lấy phiếu tín nhiệm, bỏ phiếu tín nhiệm, đặc biệt trong bối cảnh tiếp tục xâydựng và hoàn thiện Nhà nước pháp quyền xã hội chủ nghĩa Việt Nam hiện nay.
Tráfico de madera y especies forestales en sedes fiscales ambientales de Moyobamba, Juanjuí y Yurimaguas, Perú 2022-2023
Authors: Ordoñez Ruiz Karina Milagros , Ordóñez Sánchez Luis Alberto , Díaz Aguilar Jeiber , Panta Huamán Anthony Junior , Fernández Herrera Hoyler
Published: September 2023

La investigación es descriptiva, tiene como objetivo conocer el accionar de las Fiscalías Ambientales de Moyobamba, Juanjuí y Yurimaguas. Las preocupaciones surgen de los efectos devastadores que tiene esta actividad ilegal. Se trabajó con el análisis relacional de Gray, para establecer el accionar de cada sede fiscal. Se tomó en cuenta la variable Efectividad de las sedes fiscales de Moyobamba, Juanjuí y Yurimaguas en la incautación de especies forestales; así como, el tráfico de madera y especies forestales. El volumen del tráfico de madera incautado en las tres sedes fiscales, supera las 625 134 pt (pies tablares) en lo que va del año. La especie tornillo es la más afectada que, ocupa el primer lugar. La fiscalía de Yurimaguas realizó 80 operativos. La fiscalía de Juanjuí presenta 43 sentencias con pena privativa de la libertad por tráfico de madera y especies forestales. Existen casos investigados y con sentencias efectivas concluyéndose que "más es mejor"; por otro lado, el volumen de madera incautada y las sentencias suspendidas, concluye que, "menos es mejor".
Exploración Integral de la Gestión Pública en el Desarrollo Territorial: Una revisión sistemática
Authors: Sullca Bartolome Yakelyn Teresa , Villafuerte Alvarez Carlos Alberto , Quiñones Colchado Elva Rosa
Published: September 2023

Este ensayo se sitúa en el marco del método deductivo, dentro del paradigma positivista, con un enfoque cualitativo, de tipo descriptivo, y un diseño narrativo de tópico. La gestión pública desempeña un papel fundamental en el desarrollo territorial de un país al brindar directrices para impulsar el desarrollo sostenible. A través de una revisión sistemática de 42 artículos científicos de los últimos 5 años, se analiza la gestión pública en el desarrollo territorial en diferentes países. Se concluye que es necesario mejorar la gestión pública en áreas como educación, bienestar social, economía y política, ya que los beneficios no se distribuyen de manera equitativa en la población. Este estudio destaca la importancia de alinear los objetivos estatales con las necesidades de la ciudadanía, promover la transparencia y la rendición de cuentas, y superar obstáculos como la falta de implementación efectiva de políticas y la falta de coordinación interinstitucional. El análisis también muestra la relevancia de abordar desafíos actuales en la gestión pública, especialmente en un contexto de creciente escasez de recursos y evolución de patrones de uso del suelo, agravados por la pandemia de COVID-19. La desigualdad persistente en el desarrollo territorial en América Latina plantea desafíos adicionales, y se resalta la necesidad de estrategias para un desarrollo local viable y sostenible. En última instancia, este estudio busca generar una valoración de cómo los gobiernos gestionan el desarrollo de la sociedad y administran recursos económicos, políticos, culturales y de bienestar social, en beneficio de los ciudadanos.
Editorial
Authors: De Vincenzi Marcelo , Darín Susana , Maccarini Marcela , Pons Claudia
Published: September 2023

Esta edición de la revista RAIA contiene una selección de las ponencias presentadas en el XVI Congreso Internacional de Innovación Tecnológica Informática, CIITI 2018. El congreso fue organizado por la Facultad de Tecnología Informática y su Centro de Investigación, CAETI, de la Universidad Abierta Interamericana, UAI. El CIITI es un espacio para la difusión, promoción y reflexión sobre la importancia de la innovación tecnológica informática como factor de competitividad. El mismo se desarrolló en la Ciudad Autónoma de Buenos Aires, el jueves 27 de septiembre de 2018 en el auditorio del Palais Rouge y el jueves 1 de noviembre 2018 en la Ciudad de Rosario, en el Aula Magna de la UAI.
Identificación de biomarcadores con poder pronóstico en cáncer: una perspectiva desde la ciencia de datos biomédicos y la bioinformática
Authors: Menazzi Sebastián , Chanfreau Hernán , Nastasi David , Lichowski Uan Martín , Martinez Diego , Camele Genaro , Butti Matías
Published: September 2023

En el estudio del cáncer, los perfiles de expresión génica tienen gran relevancia dado que permiten conocer la actividad de genes de interés en el tejido en análisis. El avance biotecnológico y la disminución de costos de secuenciación han permitido producir grandes volúmenes de datos moleculares incluidos los perfiles de expresión génica, que pueden ser analizados junto con los datos de supervivencia (recidiva de un tumor u óbito) para obtener información valiosa sobre el pronóstico del paciente. El objetivo es identificar perfiles de expresión que muestren asociación con características clínicamente accionables, como respuesta a un tratamiento o capacidad de recidiva del tumor.

 

El análisis de estos grandes volúmenes de datos biomédicos requiere de conocimiento computacional, bioinformático y bioestadístico. La plataforma Bioplat permite democratizar estos análisis y es especialmente útil para equipos que tienen la experiencia biológica pero no la computacional/ bioestadística. Además integra múltiples fuentes de datasets, permite incorporar datos propios y provee una base de datos curada. Ofrece puntos de extensión para que científicos de la computación puedan incorporar fácilmente nuevos algoritmos, herramientas o técnicas de machine learning.
Certamen de Trabajos Estudiantiles IX CIITI-TE 2018
Authors: Pons Claudia
Published: September 2023

El Certamen de Trabajos Estudiantiles (IX CIITI-TE) es un espacio de encuentro destinado a fomentar la interacción de los estudiantes de grado y posgrado de las universidades argentinas. El certamen permitió el intercambio de ideas y experiencias y brindó un medio adecuado para la difusión de la producción intelectual que los estudiantes realizan en el marco de sus carreras universitarias.

En este certamen participaron 30 trabajos provenientes de alumnos de distintas universidades del país. Los 5 mejores trabajos de cada categoría fueron expuestos durante el congreso en formato de poster y luego de su evaluación por parte de un Comité de expertos, los mejores trabajos fueron seleccionados y recibieron premios.
Uso de Técnicas de Inteligencia Artificial para el Análisis del Impacto de Ambientes Contaminantes en el Índice de Daño Genético Humano
Authors: Kamlofsky Jorge , Miana Vanesa , Prieto Gonzalez Elio
Published: September 2023

Las técnicas de Inteligencia Artificial (IA) hoy están difundidas en casi todas las disciplinas. En el ámbito de la salud, se las aplica en etapas operacionales de la investigación: sobre bancos de datos se pueden presentar modelos cuya validación se plasma en nuevo conocimiento científico. Sin embargo, en investigaciones específicas, los investigadores deben recopilar sus datos. Estas investigaciones son costosas, por lo que muchas veces, con resultados preliminares basados en pocos datos, se define si se avanza con la investigación o no.

En este trabajo se presenta las tareas que permiten obtener un modelo que permite describir y predecir el impacto en el daño genético evaluado mediante la técnica del ensayo cometa. Este trabajo se basó en el análisis de 54 casos. Se obtuvieron modelos de regresión lineal múltiple previo a un proceso de selección de variables basado en la Teoría de la Información de Shannon (1948). Los modelos obtenidos se evaluaron con el indicador R2. Si bien el evaluador obtenido no se encuentra en los niveles recomendables, es suficiente para presentar indicios interesantes.
Construcción de Tecnología CARE basado en implementación de Lenguajes Específicos de Dominio y su aplicación en ambientes de modelado de sistemas de información sanitaria
Authors: Nahuel Leopoldo , Caputti Matías , Zugnoni Iván , Paganini Lucas , Cesaretti Juan , Rocca Leandro , Giandini Roxana
Published: September 2023

Innovando en la forma de poner en práctica Ingeniería de Requerimientos Dirigida por Modelos IRDM en el contexto del paradigma Desarrollo Dirigido por Modelos MDD, nuestro trabajo consiste en el diseño y desarrollo de una herramienta CARE (Computer-Aided Requirements Engineering) que asista en el uso de nuestro Lenguaje Específico del Dominio (DSL) para Sistemas de Información Sanitaria, al que llamamos DSL_SALUD. Esta herramienta permite crear modelos escritos en el lenguaje DSL y transformarlos automáticamente a otros modelos escritos en lenguaje UML (por ejemplo: diagrama de clases UML).
Spectroflourometric and Spectrophotometric Methods for the Determination of Sitagliptin in Binary Mixture with Metformin and Ternary Mixture with Metformin and Sitagliptin Alkaline Degradation Product
Authors:   Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo University, Kasr El-Aini St., Cairo, Egypt, Ayoub Bassam M. , El-Bagary Ramzia I. , Elkady Ehab F.
Published: September 2023

Simple, accurate and precise spectroflourometric and spectrophotometric methods have been developed and validated for the determination of sitagliptin phosphate monohydrate (STG) and metformin HCL (MET). Zero order, first derivative, ratio derivative spectrophotometric methods and flourometric methods have been developed. The zero order spectrophotometric method was used for the determination of STG in the range of 50-300 μg mL-1. The first derivative spectrophotometric method was used for the determination of MET in the range of 2-12 μg mL-1 and STG in the range of 50-300 μg mL-1 by measuring the peak amplitude at 246.5 nm and 275 nm, respectively. The first derivative of ratio spectra spectrophotometric method used the peak amplitudes at 232 nm and 239 nm for the determination of MET in the range of 2-12 μg mL-1. The flourometric method was used for the determination of STG in the range of 0.25-110 μg mL-1. The proposed methods used to determine each drug in binary mixture with metformin and ternary mixture with metformin and sitagliptin alkaline degradation product that is obtained after alkaline hydrolysis of sitagliptin. The results were statistically compared using one-way analysis of variance (ANOVA). The methods developed were satisfactorily applied to the analysis of the pharmaceutical formulations and proved to be specific and accurate for the quality control of the cited drugs in pharmaceutical dosage forms.
Statistical Modeling of Lung Cancer: Answering Relative Questions
Authors:   Department of Mathematics and Statistics, University of South Florida, Tampa, FL, USA, Cong Chunling , Tsokos Chris. P. ,   Department of Mathematics and Statistics, University of South Florida, Tampa, FL, USA, Kepner James , Gapstur Susan , Flanders Dana , Jacob Eric ,   American Cancer Society, Atlanta, USA
Published: September 2023

The objective of this paper is to perform parametric and nonparametric analysis to address some very important questions concerning lung cancer utilizing real lung cancer data: What is the probabilistic nature of mortality time in ex-smoker lung cancer patients and non-smoker lung cancer patients, for female, male, and the totality of female and male patients? Is there significant difference of mortality time between ex-smoker and non-smoker patients? For ex-smokers, are there any differences with respect to the key variables such as mortality time, cigarettes per day (CPD), and duration of smoking between female and male patients? For non-smokers, can we notice a difference in mortality time between female and male patients? Can we accurately predict mortality time given information on CPD, starting time and quitting time for a specific lung cancer patient who smokes? Thus best fitting probability distributions are identified and their parameters are estimated. Mean mortality times are compared between non-smokers and ex-smokers, female non-smokers and male non-smokers, and female ex-smokers and male ex-smokers. Important entities related to lung cancer mortality time, such as cigarettes per day (CPD), and duration of smoking (DUR), are compared between female and male ex-smoker lung cancer patients. Finally, a model is developed to predict the mortality time of ex-smokers with a high degree of accuracy.
High Prevalence of Iron Deficiency among Educated Hospital Employees in Switzerland
Authors:   Medical Clinic, Department of Medicine, University Hospital Zurich, Zurich, Switzerland, Schuepbach Reto A. , Bachli Esther B. ,   Medical Clinic, Department of Medicine, University Hospital Zurich, Zurich, Switzerland, Bestmann Lukas ,   Institute of Clinical Chemistry, University Hospital Zurich, Zurich, Switzerland, Bechir Markus ,   Division of Surgical Intensive Care, University Hospital Zurich, Zurich, Switzerland, Fehr Jorg ,   Division of Haematology, Department of Medicine, University Hospital Zurich, Zurich, Switzerland
Published: September 2023

Iron deficiency is known to cause symptoms such as fatigue, depression and restless legs syndrome resulting in impaired quality of life and working capacity. We sought to examine the iron status of reportedly healthy individuals by a framed study design in 58 highly educated Swiss hospital employees and to compare the use of non invasive tests for assessing iron deficiency (ID). A structured interview was used to assess health status, nutritional intake and potential blood loss, blood counts as well as parameters proposed to diagnose iron deficiency were determined. All subjects felt well and were working at their maximum capacity. The male subjects were neither anaemic nor had decreased iron parameters however 50% (23/46) of the women had a serum ferritin of below 22 μg/L, still 33% (15/46) of the women had a ferritin value below the more stringent cut off value of 15 μg/L. In 15% (7/46) of the women we diagnosed iron deficient anaemia. Red meat consumption correlated with ferritin values as did the menstrual blood loss which was estimated by asking the amount of tampons used. Of the additionally analysed iron parameters only the percentage of hypochromic erythrocytes, soluble transferrin receptor and transferrin values were significantly correlated with ferritin and reached an AUCROC of ≥0.7 indicating good predictive tests. Nevertheless neither soluble transferrin receptor nor transferrin showed diagnostic advantages for the diagnosis of ID compared to ferritin alone or together with erythrocyte parameters. Working in a hospital environment and having access to health education does not seem to correlate with prevention of ID or ID anaemia in female hospital employees.
Clinical Study of Advanced Glycation End Products in Egyptian Diabetic Obese and Non-Obese Patients
Authors:   Department of Biochemistry, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt, Amin Mohamed N. , Mosa Amany A. ,   Department of Internal Medicine, Specialized Medical Hospital, Faculty of Medicine, Mansoura University, Mansoura, Egypt, El-Shishtawy Mamdouh M. ,   Department of Biochemistry, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt
Published: September 2023

Advanced glycation end products (AGEs) are complex, heterogenous molecules generated by glycation and oxidation of proteins in vivo, which are thought to markedly increase in diabetic patients. One of the recently identified AGEs is carboxy methyl lysine (CML), which is the main ligand of receptors for advanced glycation end products (RAGE). The present study aimed to assess the effect of obesity on such pathways in presence and absence of Type 2 diabetes mellitus. CML, soluble receptors for advanced glycation end products (sRAGE), HbA1C, lipid profile, liver function tests and kidney function tests were determined in 29 diabetic obese, 29 diabetic non-obese, 15 non-diabetic obese and 15 non-diabetic non-obese subjects. The study compared obese and non-obese subjects in presence and absence of type 2 diabetes. The results showed a significant increase in CML and a significant decrease in sRAGEineach of the diabetic obese group when compared with the diabetic non-obese group and the non-diabetic obese group when compared with the non-diabetic non-obese group. A significant positive correlation was found between CML and markers of obesity (body mass index and waist/hip ratio). These results suggest that obesity can increase CML independent of diabetes and support the reports that CML could be generated from both sugars and lipids. The present study suggests that treatment using glycation inhibitors like aminoguanidine or recombinant sRAGEwill not only retard the diabetic complications, but may also have a prophylactic effect.
Gene Encoding Chitinase 3-Like 1 Protein (CHI3L1) is a Putative Oncogene
Authors:   Department of Biosynthesis of Nucleic Acids, Institute of Molecular Biology and Genetics, National Academy of Sciences of Ukraine, 150 Zabolotnogo Street, Kyiv, Ukraine, Kavsan Vadym M. , Balynska Olena V. , Iershov Anton V. , Areshkov Pavlo O. , Rymar Vadym I. ,   Department of Biosynthesis of Nucleic Acids, Institute of Molecular Biology and Genetics, National Academy of Sciences of Ukraine, 150 Zabolotnogo Street, Kyiv, Ukraine, Baklaushev Vladimir P. , Yusubalieva Gaukhar M. , Grinenko Nadezhda Ph. , Victorov Ilya V. ,   Laboratory of Immunochemistry, V.P. Serbsky National Research Centre for Social and Forensic Psychiatry, RUSA Ministry of Health, Moscow, Russia, Chekhonin Vladimir P. ,   Chair of Medical Nanobiotechnology N.I. Pirogov Russian State Medical University, Moscow, Russia, Sanson Marc ,   AP-HP, Groupe Hospitalier Pitie-Salpetriere, Service de Neurologie Mazarin and UMR 975 INSERM-UPMC, Paris, France
Published: September 2023

An important task in understanding oncogenesis is the identification of those genes whose copy number and expression increase during tumorigenesis. Previously, in an effort to identify genes which could be used as molecular markers for glial tumors, we compared gene expression in glioblastoma to the normal brain cells. Among the genes with the most pronounced increased expression in tumors there was CHI3L1, encoding the secreted chitinase 3-like 1 protein (also known as HC gp-39 or YKL-40). Expression of CHI3L1 was found increased significantly in various tumors in comparison with corresponding normal tissues. Here we show that CHI3L1 can decrease the doubling time of 293 cells. We have also demonstrated that CHI3L1 allows the anchorage-independent growth in soft agar and, in addition, stable CHI3L1 expression made 293 cells tumorigenic: these cells stimulate the initiation of tumors after their xenograft transplantation into the Wistar rat brains. Thus, the overexpression of CHI3L1 is likely to be critical in the development of some tumors and when we gain more information about mechanisms of CHI3L1 oncogenicity, it could be used as one of the potential targets for anticancer therapy.
Relevant Networks involving the p53 Signalling Pathway in Renal Cell Carcinoma
Authors:   INIBIC, CHU A Coruña. A Coruna, Spain, Villaamil V. Medina , Gallego G. Aparicio , Caínzos I. Santamarina ,   INIBIC, CHU A Coruna. A Coruna, Spain, Ruvira L. Valbuena ,   Department of Pathology. Modelo Hospital. A Coruna, Spain, Valladares-Ayerbes M. ,   Department of Oncology. CHU A Coruna. A Coruna, Spain, Anton Aparicio L. M. ,   Department of Medicine University of A Coruna. A Coruna, Spain
Published: September 2023

Introduction: Renal cell carcinoma is the most common type of kidney cancer. A better understanding of the critical pathways and interactions associated with alterations in renal function and renal tumour properties is required. Our final goal is to combine the knowledge provided by a regulatory network with experimental observations provided by the dataset. Methods: In this study, a systems biology approach was used, integrating immunohistochemistry protein expression profiles and protein interaction information with the STRING and MeV bioinformatics tools. A group consisting of 80 patients with renal cell carcinoma was studied. The expression of selected markers was assessed using tissue microarray technology on immunohistochemically stained slides. The immunohistochemical data of the molecular factors studied were analysed using a parametric statistical test, Pearson's correlation coefficient test. Results: Bioinformatics analysis of tumour samples resulted in 2 protein networks. The first network consists of proteins involved in the angiogenesis pathway and the apoptosis suppressor, BCL2, and includes both positive and negative correlations. The second network shows a negative interaction between the p53 tumour suppressor protein and the glucose transporter type 4. Conclusion: The comprehensive pathway network will help us to realise the cooperative behaviours among pathways. Regulation of metabolic pathways is an important role of p53. The pathway involving the tumour suppressor gene p53 could regulate tumour angiogenesis. Further investigation of the proteins that interact with this pathway in this type of tumour may provide new strategies for cancer therapies to specifically inhibit the molecules that play crucial roles in tumour progression.
Validated High-Performance Liquid Chromatographic Method for the Estimation of Rosuvastatin Calcium in Bulk and Pharmaceutical Formulations
Authors:   Analytical Biochemistry Laboratory, Department of Chemistry, Faculty of Science, University of Aleppo, Aleppo, Syria, Ashour Safwan , Omar Soulafa
Published: September 2023

A reversed-phase high-performance liquid chromatographic method was developed and validated for the determination of rosuvastatin calcium in pharmaceutical dosage forms. The determination was performed on a Nucleodur column C8 (250 × 4.6 mm i.d., 5 μm particle size); the mobile phase consisted of a mixture of 0.1Mformic acid and methanol (25:75, v/v), pumped at a flow rate 1.0 mL min-1. The photodiode array detector was operated at 280 nm. The retention times for rosuvastatin and fluvastatin, which was used as internal standard, were 3.98 and 7.78 min, respectively. Linearity range (r2better than 0.999, n=6) was 3.0-1602.0 μg mL-1 with limit of detection value of 0.12 μg mL-1. The precision of the method was demonstrated using intra- and inter-day assay RSD% values which were less than 2.40%, while the recovery was 99.86-102.86%. The method was applied in the quality control of commercial tablets and content uniformity test and proved to be suitable for rapid and reliable quality control.
HIV-Related Sexual Behaviors among Migrants and Non-migrants in Rural Ethiopia:Role of RuraltoUrbanMigration in HIV Transmission
Authors:   School of Public Health, College of Health Sciences, Addis Ababa University, Ethiopia, Tamiru Melesse , Hailemariam Damen , Mitike Getnet , Haidar Jemal
Published: September 2023

Objective: To compare HIV-related sexual risk behavior among temporary ruraltourban migrants and non-migrants and to explore the role of migration in HIV transmission in a rural area of Ethiopia.Methods: A cross-sectional comparative study was conducted in Bure Woreda, West Gojam, Amhara Region, Ethiopia. A total of 1,310 male subjects (655 rural to urban migrants and 655 non-migrants) were selected randomly and were assessed,analyzed using SPSS version 17 software for their HIV related sexual risk behavioursincluding the role of migration in HIV transmission in a rural Ethiopia. Twopartsof questionnaires were prepared and used for comparing the above groups. The first part of the questionnaires included non-sensitive questions such as demographics and HIV knowledge while the second part comprisedsensitive questions related to sexual behaviors. Results: When multiple sexual partners, sex with commercial sex workers, sexual transmitted infections and premarital sex compared between the two groups, the proportions of rural to urban migrantsVs non- migrants who had multiple sexual partners (31.4 % Vs 7.4%), sex with commercial sex workers (22.3% Vs 13.3%), sexual transmitted infections (11.7% Vs 3.2%) and premarital sex (20.8% Vs 14.2 %)were significantly higher in ruraltourban migrants than non-migrants. Among those who had multiple sexual partners, only 12.7 % of, rural to urban migrants and9.8 % of non-migrants reported consistent condom use with sexual partners other than their spouse. Conclusions: As both rural to urban migrants and non-migrants are at risk for HIV infection, intervention programmes targeting both groups are recommended. However, in order to contain the bridging effect on HIV transmission from urban to rural areas particular attention should be given for the rural to urban migrant population.
Perspectiva de género en la expresión corporal y motriz en educación inicial
Authors:   UNIVERSIDAD DE GUAYAQUIL, Mantilla Pacheco Delfa Narciza , Zeballos Chang Julia Lorena , Arboleda Viteri Inga Paulina , Mendoza Vera Raquel Mirey , Tamayo Nieto Kimberly Lisbeth
Published: September 2023

La relación de los niños y niñas dentro del aula, fuera de ella, incluso a la hora de jugar en cualquier sitio no es igual; por lo general los niños con los niños y las niñas con las niñas lo que evidencia la presencia de roles diferenciados o los famosos estereotipos de género. La presente investigación tiene como finalidad analizar la influencia de los roles de género en el desarrollo corporal y motriz en los estudiantes del subnivel inicial 2 de educación inicial de un centro educativo de la ciudad de Guayaquil. Se enmarca en una metodología cuali-cuantitativa a través de una investigación de campo y bibliográfica cuyo estudio se realizó con 49 implicados entre niñas y niño, docente, directivo y representantes. Se concluye que la comunidad educativa está sensibilizada en su percepción de actividades que deben realizar niñas y niños independiente de su sexo y muestran aceptación a contar con un manual pedagógico que fortalezca relaciones equitativas
Percutaneous versus Cutdown Access for Endovascular Aortic Repair
Authors: Altoijry Abdulmajeed , Alsheikh Sultan , Alanezi Tariq , Aljabri Badr , Aldossary Mohammed Yousef , Altuwaijri Talal , Iqbal Kaisor
Published: September 2023

Background: This study aimed to compare the outcomes of the percutaneous femoral access and open surgical cutdown access approaches in patients undergoing thoracic/abdominal endovascular aortic repair. Methods: We retrospectively reviewed the medical records of 59 patients who underwent a thoracic/abdominal endovascular aortic repair at a single tertiary care hospital between 2015 and 2022. Based on their femoral access type, the patients were categorized into the “percutaneous” or “cutdown” groups. Using a computerized sheet, relevant patient data (including demographic information and patient risk factors) were collected. The operative duration, complication rates, mortality rates, intensive care unit admission and stay durations, and total hospital stay were compared between the two groups. The primary outcomes were differences in the postoperative morbidity and mortality associated with the two approaches. Results: The cutdown and percutaneous groups comprised 24 (41%) and 35 (59%) patients, respectively. The two groups displayed comparable demographic and clinical characteristics (p > 0.05). However, the vascular anatomy differed with the common femoral artery diameter being larger in the percutaneous group compared to the cutdown group (9.63 ± 1.81 mm vs. 8.49 ± 1.54 mm, p = 0.028). The ratio of the sheath diameter to the common femoral artery diameter was significantly lower in the percutaneous group than in the cutdown group (0.73 ± 0.16 vs. 0.85 ± 0.20, p = 0.027). A ratio of ≥0.74 was associated with a higher risk of complications (odds ratio, 12.0; 95% confidence interval, 1.4–102.2; p = 0.023) and mortality (odds ratio, 5.79; 95% confidence interval, 1.13–29.6; p = 0.035). Additionally, the operative duration was significantly shorter in the percutaneous group than in the cutdown group (141.43 ± 97.05 min vs. 218.46 ± 126.31 min, p = 0.001). Compared to the cutdown group, the percutaneous group experienced a shorter total hospital stay (21.54 ± 21.49 days vs. 11.60 ± 12.09 days, p = 0.022) and lower intensive care unit-admission rates (66.7% vs. 40%, p = 0.044). Conclusion: The percutaneous approach is a viable and more time-efficient alternative to the traditional cutdown method for delivering vascular endografts. It is associated with a significantly shorter operative duration and briefer hospital stays. Additionally, the ratio of the sheath diameter to the common femoral artery diameter can help surgeons preoperatively predict and anticipate the risks of complications and mortality. Future in-depth research is necessary to better understand the association between this ratio and postoperative outcomes and complications.
Programa de intervención para el manejo del estrés en estudiantes universitarios
Authors: Cuenca Cristian Franco , Osorio Guzmán Maricela
Published: September 2023

El estrés está presente durante la formación de los estudiantes universitarios; diversas investigaciones indican que este presentó un aumento a causa de la pandemia por el virus SARS-CoV-2, específicamente ante el retorno a las actividades académicas presenciales; el objetivo del presente trabajo fue evaluar los resultados de un programa de intervención psicológica dirigido a disminuir la frecuencia de respuestas fisiológica asociadas al estrés y el nivel de estrés percibido en estudiantes de nivel licenciatura. Participaron 105 alumnos de una Universidad Pública del Estado de México, 34.3% eran hombres y 65.7% mujeres (media edad de 21.78 años; DE=4.78), de diversas carreras, se usó un diseño pretest-postest, y se aplicaron una cédula de datos generales, la Escala Sintomática del Estrés (ESE) y la Escala de Estrés Percibido (PSS). En el programa de 4 sesiones se abordaron estrategias de relajación, entrenamiento en habilidades sociales y solución de problemas. Los resultados indican una disminución en la frecuencia de respuestas fisiológicas asociadas al estrés, así como diferencias significativas antes y después de la intervención (t= 2.40; p= 0.01; d= 0.23), misma situación para los niveles de estrés percibido (t= 2.441; p= 0.016; d=0.24), se concluye que la propuesta de abordaje para el manejo del estrés en universitarios resultó eficaz.
Promoción de los derechos de la infancia y la adolescencia en comunidades indígenas
Authors: Vargas Garduño María de Lourdes , Méndez Puga Ana María , Vargas Silva Alethia Dánae , Flores Manzano Nelva Denise
Published: September 2023

Actualmente resulta fundamental la promoción de los derechos de los niños, niñas y adolescentes (NNA), especialmente en comunidades indígenas, que han sido invadidas por la corrupción y el crimen organizado. El texto tiene como objetivo describir el proceso de promoción del conocimiento, reflexión, ejercicio y difusión de los derechos de la infancia y la adolescencia, a partir de un taller psicoeducativo centrado en grupos dialógicos. Se siguió la metodología de investigación-acción. Las técnicas empleadas fueron: observación, entrevistas, recuperación de discursos y encuestas. Entre los resultados, destaca la construcción de espacios de participación que permitieron el intercambio de ideas y experiencias sobre los derechos de las infancias y adolescencias, entre los participantes. Se concluye que se logró la sensibilización de padres y madres de familia sobre el tema y que la metodología interdisciplinaria y dialógica permitió un ejercicio investigativo donde infantes y adolescentes fueron protagonistas y no meros objetos de investigación.
Un análisis de la colonialidad en la Normal Superior Simón Bolívar
Authors: Omar Salas Juan
Published: September 2023

Ya en los primeros años de este siglo, ante el surgimiento creciente del pensamiento de la modernidad/colonialidad, en América Latina, las Universidades y Normales Superiores de Estudio en Bolivia en tanto instituciones estatales y una parte de los intelectuales bolivianos atienden el análisis de la sociedad con el impulso que significa tener un nuevo camino de interpretación. El objetivo del estudio fue analizar, a partir del trabajo ¨Reproducción de la colonialidad y mantenimiento de estructuras subjetivas coloniales en un espacio de educación superior¨ (Alcón R.,2008) la colonialidad en la enseñanza superior estatal a partir de la Normal Superior Simón Bolívar de la ciudad de La Paz para destacar la emigración campo-ciudad y sus repercusiones en la estructura social estudiantil de dicha institución y como eje impulsor y articulador de una serie de conductas, imaginarios colectivos e individuales que reinan en la institución educativa. Metodológicamente es cualitativa, bajo un enfoque hermenéutico. Los resultados se identificaron en la red de relacionamiento existente dentro de la institución, conductas e imaginarios individuales y colectivos manifiestos en forma de estigmatización y discriminación. Se concluyó que la reproducción de la colonialidad dentro la institución educativa y la contradicción existente entre el ser y el deber ser, entre el hecho y el enunciado, es otro rasgo de la colonialidad del poder reinante.
Títeres: impulsores del desarrollo de la lengua oral en aymara
Authors: Mamani Nina Antonio
Published: September 2023

La investigación se centra en el papel de los títeres como impulsores del desarrollo de la lengua oral en aymara. Los títeres se presentan como una herramienta efectiva para impulsar el desarrollo de la lengua oral en aymara. El objetivo de este estudio fue analizar cómo los títeres contribuyen al desarrollo del lenguaje oral en aymara en seis niños y niñas de 5 a 6 años que asisten a la Unidad Educativa Villa Alicia en la comunidad Chirapaca, provincia Los Andes. Metodológicamente fue cuantitativa con un enfoque inductivo y un diseño preexperimental. Se utilizaron cuestionarios como instrumentos de evaluación. Los resultados de la investigación muestran una hubo una mejora significativa en el desarrollo de la lengua oral en aymara en niños de 5 a 6 años de la Unidad Educativa Villa Alicia en Chirapaca, al utilizar títeres como estrategia didáctica. En conclusión, el uso de títeres logró de manera lúdica un abordaje pedagógico satisfactorio de la lengua oral en aymara.
طرق تدريس مهارة الكلام في الصف الثاني الثانوي بمعهد البركة سومطرة الشماليةسيمالونجون
Authors: Suhendri  , Zaky Ahmad , Ulum Bahrul
Published: September 2023

أما أهداف كتابة هذا البحث هي: (1) معرفة طرق تدريس مهارة الكلام المستخدمة في الصف الثاني الثناوي بمعهد البركة سيمالونجون سومطرة الشمالية، (2) معرفة أسباب ضعف الطلاب  في مهارة الكلام بطرق المستخدمة في الصف الثاني الثناوي بمعهد البركة سيمالونجون سومطرة الشمالية، (3) معرفة حلول تدريس مهارة الكلام في الصف الثاني بمعهد البركة سيمالونجون سومطرة الشمالي، وهذا البحث يستخدم بطريقة الكيفي وهي طريقة التى يجمع الباحث المعلومات للوصول إلى وصف مراد دراسته من خلال منهجية عملية صحيح  عند البحث. ونتائج هذا البحث هي: (1) أن طرق تدريس مهارة الكلام  المستخدمة في الصف الثاني الثناوي بمعهد البركة سيمالونجون سومطرة الشمالية هي طريقة الإلقائية والمباشرة. (2) وأما أسباب ضعف الطلاب في مهارة الكلام بطرق المستخدمة في الصف الثاني الثناوي بمعهد البركة هي الطريقة خاطئة في تدريس اللغة العربية وعدم تطبيق مهارة الكلام، وعدم وسائل الإعلام الدائمة وعدم العقاب الشديد لمخالف اللغة، 3) وأما حلول تدريس مهارة الكلام  في الصف الثاني الثناوي بمعهد البركة هي: ترقية طرق تدريس مهارة الكلام عند المعلمين وجعل الدورة لتدريب المدرسين في تدريس اللغة العربية وإعداد خطط الدراسية والمواد الجيدة قبل تدريس، وحلول أسباب ضعف الطلاب في مهارة الكلام المستخدمة في الصف الثاني الثناوي بمعهد البركة استخدام طرق المناسبة في تدريس مهارة الكلام، وتطبيق اللغة العربية دائما، وعقد العقاب لمن يخالف اللغة، ومزيد المحادثة وتدريب الخطابة باللغة العربية،  واستخدام وسائل الإعلام الدائمة عند تدريس مهارة الكلام.
The Influence of Communication Skills toward Social Interaction Students in Buddhist College
Authors: Avitasari Iin , Seneru Wistina , Sumarwan Edi , Wibawa Resdhi , Rapiadi
Published: September 2023

Effective social interaction is essential to everyday life, especially in an educational environment. Students of Jinarakkhita College of Lampung undergoing lectures need good speaking skills to interact with fellow students and related parties in the campus environment. This study aims to analyze the influence of speaking skills on student social interaction at STIAB Jinarakkhita Lampung. The research method used was a quantitative study using questionnaires distributed to the active student population on the campus. The results showed that the ability to speak significantly influenced the social interaction of students at STIAB Jinarakkhita Lampung. Students with good speaking skills tend to express their thoughts and ideas better clearly and in structure, facilitating effective communication in various social interaction situations. In addition, good speaking skills also affect students' ability to listen well and understand other people's perspectives. With good speaking skills, students can avoid misunderstandings and increase empathy for others, which in turn will strengthen healthy and harmonious social interactions in the campus environment. This research has important implications for academics and decision-makers at STIAB Jinarakkhita Lampung in designing strategies and activities to develop speaking skills for students. By improving speaking skills, it is hoped that social interaction on campus can be improved, create an inclusive environment, support each other, and contribute positively to students' educational experience at STIAB Jinarakkhita Lampung
A Case Study of Communication Skills Implementation: The Effective Communication of School Teachers during the Covid-19 Pandemic
Authors: Edi Sumarwan  , Rapiadi Rapiadi , Avitasari Iin , Gautama Sidartha Adi , Seneru Wistina
Published: September 2023

This study analyzes effective communication in Buddhist Religious Education (BRE) learning during the Covid-19 pandemic at Bandar Agung Elementary School 4, Bandar Sribhawono Subdistrict. The study utilizes a qualitative approach and a case study method. Data is collected through observation, interviews, and documentation, which are then analyzed using the Miles and Huberman data analysis model. The research findings indicate that teachers use WhatsApp and video calls as communication channels for distance learning. Teachers also involve parents or family members of the students as communication intermediaries. Interactive teaching methods such as questioning, discussions, and lectures are employed. The study also identifies communication barriers such as limited internet access and technological proficiency. Teachers address these barriers by directly communicating with students and parents through home visits. This research highlights the importance of effective communication in BRE learning during the Covid-19 pandemic and the strategies used to overcome communication challenges.
The Practice of Mindful Communication Brings the Strong Effect on Spiritual Intelligence of School Students
Authors: Kusuma Candra , Saputri Vike Aprilianin Marwintaria , Kasrah Rini , Yudhawati Ine , Gautama Sidartha Adi
Published: September 2023

This study aims to describe the influence analysis of students' mindful communication abilities on the spiritual intelligence of Triratna High School students in West Jakarta. Mindful communication ability is the communication ability that is adequately conveyed by being aware of aspects of language and communication ethics. Character is formed due to an understanding of the three relationships that every human being must experience. Spiritual intelligence is the foundation for intellectual and emotional intelligence to function effectively. This study used a descriptive approach and a quantitative regression method using two instruments to measure mindful communication's effect on students' mental intelligence at Triratna school, West Jakarta. The results of this study indicate that there is a positive relationship between mindful communication and cognitive intelligence. The results of this study contain implications that mindful communication has an essential role for students.
Improving the Quality of Service and Inter-Individual Communication on E-commerce Consumer Satisfaction
Authors: LUWIHA LUWIHA , Nagatirtha Partama , Meyliana Henny , Karsinah Karsinah , Saputri Vike Aprilianin Marwintaria
Published: September 2023

The general objective of this research is to determine whether or not there is an influence of interpersonal communication and service quality on consumer satisfaction. The research hypothesis is that there is an influence of interpersonal communication and service quality on customer satisfaction. The subject of this research is consumers who use e-commerce. The subjects of this study consisted of men and women aged 18-23 years, totaling 60 people at the time of the trial and 60 people at the time of data collection. The data collected through the scale is then distributed to the research subjects. The data were then analyzed statistically using multiple regression analysis with SPSS version 16.0 for Windows. The analysis results obtained the value of R = 0.777 with p = 0.000 (p <0.01). The magnitude of the coefficient of determination (R-Square) of interpersonal communication and service quality on customer satisfaction is 60.3% (0.603). The general conclusion from this study is that there is a very significant positive influence between interpersonal communication and service quality on customer satisfaction. The higher the interpersonal communication skills and the quality of service employees provide, the higher the customer satisfaction.
Classroom Management: the Impact of Transformational Leadership of Homeroom Teachers to the Effectiveness of Class Management in High Schools
Authors: Purwandoko Edi , Burmansah  , Poniman  , Priono  , Tri Anggraini
Published: September 2023

This study aims to investigate the contribution of the homeroom teacher's Transformational leadership style to the effectiveness of classroom management in Senior High Schools in Bandar Lampung City. Transformational leadership emphasizes adjusting the homeroom teacher's leadership style according to the needs of students and different classroom situations. This study used a quantitative method involving homeroom teachers and students from various high schools in Bandar Lampung City as the research sample. Data was collected through questionnaires and analyzed using appropriate statistical techniques. The results showed that the homeroom teacher's Transformational leadership style significantly influenced the effectiveness of classroom management in Senior High School Bandar Lampung City. The Transformational leadership style improves classroom discipline, student participation, quality of interaction between students and teachers, and student academic achievement. The implication of this research is the importance of developing Transformational leadership skills for homeroom teachers at Senior High School Bandar Lampung City, as well as assisting schools in developing more effective classroom management strategies to improve the quality of education.