bluuebunny/crossref_metadata_2025 huggingface dataset:
The Comprehensive Profiling of the Chemical Components in the Raw and Processed Roots of Scrophularia ningpoensis by Combining UPLC-Q-TOF-MS Coupled with MS/MS-Based Molecular Networking
Authors: Zhang Mina , Chen Kaixian , Feng Chenguo , Zhang Fang , Zhang Liuqiang , Li Yiming
Published: October 2024

Scrophulariae Radix (SR), the dried root of Scrophularia ningpoensis Hemsl (S. ningpoensis), has been extensively used as traditional Chinese medicine for thousands of years. However, since the mid-20th century, the traditional processing technology of S. ningpoensis has been interrupted. Therefore, ultra-high performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry technology, together with a Global Natural Product Social Molecular Networking (GNPS) method, was applied to comprehensively analyze the characteristic changes and mutual transformation of chemical constituents in the differently processed roots of S. ningpoensis, as well as to scientifically elucidate the processing mechanism of differently processed SR. As a result, a total of 149 components were identified. Notably, with the help of the GNPS data platform and MS2 fragment ions, the possible structures of four new compounds (47, 48, 50, and 73) were deduced in differently processed SR samples, in which 47, 48, and 50 are iridoid glycosides, and 73 is a phenylpropanoid glycoside. Five cyclopeptides (78, 86, 97, 99, and 104) derived from leucine (isoleucine) were identified in SR for the first time. The heatmaps analysis results indicated that leucine or isoleucine may be converted to cyclopeptides under the prolonged high-temperature conditions. Moreover, it is found that short-time steaming can effectively prevent the degradation of glycosides by inactivating enzymes. This study provides a new and efficient technical strategy for systematically identifying the chemical components, rapidly discovering the components, and preliminarily clarifying the processing mechanism of S. ningpoensis, as well as also providing a scientific basis for the improvement of the quality standards and field processing of S. ningpoensis.
Efficient Toluene Decontamination and Resource Utilization through Ni/Al2O3 Catalytic Cracking
Authors: Niu Yifei , Ma Xiaolong , Lu Guangyi , Zhao Dandan , Ma Zichuan
Published: October 2024

Volatile organic compounds (VOCs), particularly aromatic hydrocarbons, pose significant environmental risks due to their toxicity and role in the formation of secondary pollutants. This study explores the potential of catalytic pyrolysis as an innovative strategy for the effective remediation and conversion of aromatic hydrocarbon pollutants. The research investigates the high-efficiency removal and resource recovery of the VOC toluene using a Ni/Al2O3 catalyst. The Ni/Al2O3 catalyst was synthesized using the impregnation method and thoroughly characterized. Various analytical techniques, including scanning electron microscopy, X-ray diffraction, and N2 adsorption–desorption isotherms, were employed to characterize the Al2O3 support, NiO/Al2O3 precursor, Ni/Al2O3 catalyst, and the resulting solid carbon. Results indicate that Ni predominantly occupies the pores of γ-Al2O3, forming nano/microparticles and creating interstitial pores through aggregation. The catalyst demonstrated high activity in the thermochemical decomposition of toluene into solid carbon materials and COx-Free hydrogen, effectively addressing toluene pollution while recovering valuable resources. Optimal conditions were identified, revealing that a moderate temperature of 700 °C is most favorable for the catalytic process. Under optimized conditions, the Ni/Al2O3 catalyst removed 1328 mg/g of toluene, generated 915 mg/g of carbon material, and produced 1234 mL/g of hydrogen. The prepared carbon material, characterized by its mesoporous structure and high specific surface area graphite nanofibers, holds potential application value in adsorption, catalysis, and energy storage. This study offers a promising approach for the purification and resource recovery of aromatic volatile organic compounds, contributing to the goals of a circular economy and green chemistry.
Enhanced Chemical Stability of Tetramethylammonium Head Groups via Deep Eutectic Solvent: A Computational Study
Authors: Karibayev Mirat , Myrzakhmetov Bauyrzhan , Wang Yanwei , Mentbayeva Almagul
Published: October 2024

The chemical stability of tetramethylammonium (TMA) head groups, both with and without the presence of a choline chloride and ethylene glycol-based deep eutectic solvent (DES), was studied using Density Functional Theory (DFT) calculations and ab initio Molecular Dynamics (MD) simulations. DFT calculations of transition state energetics (ΔEreaction, ΔGreaction, ΔEactivation, and ΔGactivation) for key degradation mechanisms, ylide formation (YF) and nucleophilic substitution (SN2), suggested that the presence of DES enhances the stability of the TMA head groups compared to systems without DES. Ab initio MD simulations across hydration levels (HLs) 1 to 5 indicated that without DES, YF dominates at lower HLs, while SN2 does not occur. In contrast, both mechanisms are suppressed in the presence of DES. Temperature also plays a role: without DES, YF dominates at 298 K, while SN2 becomes prominent at 320 K and 350 K. With DES, both degradation mechanisms are inhibited. These findings suggest DES could improve the chemical stability of TMA head groups in anion exchange membranes.
Mechanism-Based Allylic Carbasugar Chlorides That Form Covalent Intermediates with α- and β-Galactosidases
Authors: Akintola Oluwafemi , Bhosale Sandeep , Bennet Andrew J.
Published: October 2024

Glycoside hydrolases have been implicated in a wide range of human conditions including lysosomal storage diseases. Consequently, many researchers have directed their efforts towards identifying new classes of glycoside hydrolase inhibitors, both synthetic and from natural sources. A large percentage of such inhibitors are reversible competitive inhibitors that bind in the active site often due to them possessing structural features, often a protonatable basic nitrogen atom, that mimic the enzymatic transition state. We report that mechanism-based small molecule galacto-like configured cyclohexenyl carbasugars form reversible covalent complexes with both α-galactosidase and β-galactosidase. In addition, we show that the β-galactosidase from Aspergillus oryzae reacts with three different carbasugar inhibitors, with three different second-order rate constants (kinact/Ki), to give the same enzyme–carbasugar covalent intermediate. The surprising observation that the α-galacto-configured inhibitor covalently labels the A. oryzae β-galactosidase highlights the catalytic versatility of glycoside hydrolases. We expect that cyclohexenyl covalent inhibitors will become an important class of compounds in the chemical biologist’s tool box.
Acacetin, a Natural Flavone with Potential in Improving Liver Disease Based on Its Anti-Inflammation, Anti-Cancer, Anti-Infection and Other Effects
Authors: Chen Kuihao , Gao Zhe
Published: October 2024

Liver disease is a global public problem, and the cost of its therapy is a large financial burden to governments. It is well known that drug therapy plays a critical role in the treatment of liver disease. However, present drugs are far from meeting clinical needs. Lots of efforts have been made to find novel agents to treat liver disease in the past several decades. Acacetin is a dihydroxy and monomethoxy flavone, named 5,7-dihydroxy-4′-methoxyflavone, which can be found in diverse plants. It has been reported that acacetin exhibits multiple pharmacological activities, including anti-cancer, anti-inflammation, anti-virus, anti-obesity, and anti-oxidation. These studies indicate the therapeutic potential of acacetin in liver disease. This review discussed the comprehensive information on the pathogenesis of liver disease (cirrhosis, viral hepatitis, drug-induced liver injury, and hepatocellular carcinoma), then introduced the biological source, structural features, and pharmacological properties of acacetin, and the possible application in preventing liver disease along with the pharmacokinetic and toxicity of acacetin, and future research directions. We systemically summarized the latest research progress on the potential therapeutic effect of acacetin on liver disease and existing problems. Based on the present published information, the natural flavone acacetin is an anticipated candidate agent for the treatment of liver disease.
Photoprotective Effects of Yeast Pulcherrimin
Authors: Kregiel Dorota , Krajewska Agnieszka , Kowalska-Baron Agnieszka , Czarnecka-Chrebelska Karolina H. , Nowak Adriana
Published: October 2024

Sunscreen products can protect the skin against the harmful effects of UV radiation, including reddening, aging, and cancer. The aim of this research was to evaluate the photoprotective effects of yeast pulcherrimin, an iron-chelating dipeptide. We first investigated the cytotoxicity of pulcherrimin produced by Metschnikowia pulcherrima yeast on the human keratinocyte HaCaT cell line, using the PrestoBlue assay. We assessed the ability of pulcherrimin to induce DNA repair after the exposure of HaCaT cells to oxidative stress. We also evaluated its protective activity against UVC radiation. The sun protective factor (SPF) was calculated using the Mansur equation. The UVA/UVB ratio values for pure pulcherrimin were evaluated using the Boots Star Rating system. The critical wavelength was determined by calculating the integrated optical density curve area. Based on the results, pulcherrimin shows strong cytoprotective effects through antioxidant and photoprotective activities on the HaCaT cell line. The calculated SPFs were 20 and 15 at pH = 7 and pH = 10, respectively. The critical wavelength above 370 nm and the UVA/UVB ratio R > 1 suggest that yeast pulcherrimin—a cyclic dipeptide containing iron—may be considered a promising photoprotective agent.
Equilibrium Structures of Propane and 2,2-Difluoropropane and Comparison with Other Two-Top Molecules
Authors: Demaison Jean , Vogt Natalja , Perrin Agnès
Published: October 2024

The Born–Oppenheimer ab initio equilibrium structures of propane (CH3)2CH2 and 2,2-difluoropropane (CH3)2CF2 were computed at the CCSD(T) level of theory using a basis set of quadruple zeta quality. The semiexperimental structure of propane was also determined from the ground state rotational constants corrected for rovibrational corrections calculated at the MP2 level of theory. Structural comparisons are made with other molecules and are discussed in terms of the quantum theory of atoms in molecules.
Optimization of Polysaccharide Extraction from Polygonatum cyrtonema Hua by Freeze–Thaw Method Using Response Surface Methodology
Authors: Wang Ziming , Wu Shushen , Wang Jiayi , Yang Ci , Wang Yang , Hu Zhan , Cai Wei , Liu Lianghong
Published: October 2024

Polygonatum cyrtonema polysaccharides have a variety of pharmacological effects. The commonly used extraction methods include traditional hot water extraction, alkaline extraction, enzymatic hydrolysis method, ultrasonic-assisted extraction, etc., but there are problems such as low yield, high temperature, high cost, strict extraction conditions, and insufficient environmental protection. In this study, crude polysaccharide extraction from the Polygonatum cyrtonema Hua was performed using the freeze–thaw method. Response surface methodology (RSM), based on a three-level, three-variable Box–Behnken design (BBD), was employed to obtain the best possible combination of water-to-raw material ratio (A: 30–50), freezing time (B: 2–10 h), and thawing temperature (C: 40–60 °C) for maximum polysaccharide extraction. Using the multiple regression analysis and analysis of variance (ANOVA), the experimental data were fitted to a second-order polynomial equation and were used to generate the mathematical model of optimization experiments. The optimum extraction conditions were as follows: a water-to-raw material ratio of 36.95:1, a freezing time of 4.8 h, and a thawing temperature of 55.99 °C. Under the optimal extraction conditions, the extraction rate of Polygonatum cyrtonema Hua polysaccharide (PCP) was 65.76 ± 0.32%, which is well in close agreement with the value predicted by the model, 65.92%. In addition, PCP has significant antioxidant activity. This result shows that the freeze–thaw method can improve the extraction efficiency, maintain the structural integrity of polysaccharides, simplify the extraction process, promote the dispersion of polysaccharides, and is suitable for large-scale industrial production.
Reversible Tuning Electrical Properties in Ferroelectric SnS with NH3 Adsorption and Desorption
Authors: Wang Wanqian , Luo Wei , Zhang Sen , Zeng Chayuan , Xie Fei , Deng Chuyun , Wang Guang , Peng Gang
Published: October 2024

Two-dimensional (2D) ferroelectrics usually exhibit instability or a tendency toward degradation when exposed to the ambient atmosphere, and the mechanism behind this phenomenon remains unclear. To unravel this affection mechanism, we have undertaken an investigation utilizing NH3 and two-dimensional ferroelectric SnS. Herein, the adsorption and desorption of NH3 molecules can reversibly modulate the electrical properties of SnS, encompassing I–V curves and transfer curves. The response time for NH3 adsorption is approximately 1.12 s, which is much quicker than that observed in other two-dimensional materials. KPFM characterizations indicate that air molecules’ adsorption alters the surface potentials of SiO2, SnS, metal electrodes, and contacts with minimal impact on the electrode contact surface potential. Upon the adsorption of NH3 molecules or air molecules, the hole concentration within the device decreases. These findings elucidate the adsorption mechanism of NH3 molecules on SnS, potentially fostering the advancement of rapid gas sensing applications utilizing two-dimensional ferroelectrics.
A Review: Recent Advances of Piezoelectric Photocatalysis in the Environmental Fields
Authors: Ye Zhengjie , Zheng Ru , Li Shuangjun , Wang Qing , Zhang Rui , Yu Chenjing , Lei Jia , Liu Xiaoyan , Zhang Dieqing
Published: October 2024

Piezoelectric photocatalysis can effectively suppress the recombination of electron holes during the course of photocatalysis, which has been widely applied in environmental and energy catalysis. Its advantage is that when the piezoelectric effect happens, a built-in electric field is formed inside the catalyst, which improves the separation efficiency of photogenerated charge carriers and obtains more excellent photocatalytic performance. The efficient conversion of mechanical energy to chemical energy can be realized through the synergistic effect of the piezoelectric effect, and photocatalysis is greatly significant in solving the energy crisis and providing environmental protection. Therefore, we organized a more complete review to better understand the mechanism and system of piezoelectric photocatalysis. We briefly introduce the principle of the piezoelectric effect, the existing types of piezoelectric photocatalysts, the practical application scenarios, and the future challenges and feasible methods to improve catalytic efficiency. The purpose of this review is to help us broaden the idea of designing piezoelectric photocatalysts, clarify the future research direction, and put it into more fields of environmental protection and energy reuse.
Carbon Nanotubes and Nanosheets for Sustainable Solutions
Authors: Paramsothy Muralidharan
Published: October 2024

This Special Issue is a continuation of the preceding Special Issue titled “70th Year Anniversary of Carbon Nanotube Discovery—Focus on Real World Solutions” [...]
Pharmacological Potential and Electrochemical Characteristics of Typha angustifolia Pollen
Authors: Abadilla Janielle Mari S. , Chen Bor-Yann , Ganzon Mike Anthony D. , Caparanga Alvin R. , Pamintuan Kristopher Ray S. , Tayo Lemmuel L. , Hsueh Chung-Chuan , Hsieh Cheng-Yang , Yang Ling-Ling , Tsai Po-Wei
Published: October 2024

Typha angustifolia L. (TA) pollen has been utilized as a traditional Chinese medicine for treating various internal and external traumas. Moreover, bioactive compounds possess diverse pharmacological activities. This study aims to evaluate the antiviral properties of TA based on its ability to generate bioenergy, capable of inhibiting viruses. TA pollens were extracted using water and ethanol solvents. These extracts were utilized to identify the phytochemical contents and correlate with the antioxidant activity via 2,2-diphenyl-1-picrylhydrazyl (DPPH) and ferric reducing antioxidant power (FRAP) assays. HPLC analysis was conducted to identify its electron-shuttling compositions. The bioenergy-generating characteristics were determined via microbial fuel cells. The water extract (TA-W) showed higher antioxidant activity due to a higher phenolic and flavonoid content compared to the ethanol extract (TA-E). Quercetin-3-O-(2G-α-L-rhamnosyl)-rutinoside, quercetin-3-O-neohesperidoside, and quercetin are the electron shuttles (ES) identified out of the 11 compounds. TA obtained a 1.39 ± 0.10 amplification factor of power generation that indicates potential bioenergy-generating and associated antiviral characteristic properties. The findings may provide a foundation for developing antiviral medications specifically designed to target virus-related diseases, while minimizing the risk of drug toxicity and reducing the costs of drug development.
A Novel Enterococcus-Based Nanofertilizer Promotes Seedling Growth and Vigor in Wheat (Triticum aestivum L.)
Authors: Batool Salma , Safdar Maryam , Naseem Saira , Sami Abdul , Saleem Rahman Shah Zaib , Larrainzar Estíbaliz , Shahid Izzah
Published: October 2024

Excessive use of chemical fertilizers poses significant environmental and health concerns. Microbial-based biofertilizers are increasingly being promoted as safe alternatives. However, they have limitations such as gaining farmers’ trust, the need for technical expertise, and the variable performance of microbes in the field. The development of nanobiofertilizers as agro-stimulants and agro-protective agents for climate-smart and sustainable agriculture could overcome these limitations. In the present study, auxin-producing Enterococcus sp. SR9, based on its plant growth-promoting traits, was selected for the microbe-assisted synthesis of silver nanoparticles (AgNPs). These microbial-nanoparticles SR9AgNPs were characterized using UV/Vis spectrophotometry, scanning electron microscopy, and a size analyzer. To test the efficacy of SR9AgNPs compared to treatment with the SR9 isolate alone, the germination rates of cucumber (Cucumis sativus), tomato (Solanum lycopersicum), and wheat (Triticum aestivum L.) seeds were analyzed. The data revealed that seeds simultaneously treated with SR9AgNPs and SR9 showed better germination rates than untreated control plants. In the case of vigor, wheat showed the most positive response to the nanoparticle treatment, with a higher vigor index than the other crops analyzed. The toxicity assessment of SR9AgNPs demonstrated no apparent toxicity at a concentration of 100 ppm, resulting in the highest germination and biomass gain in wheat seedlings. This work represents the first step in the characterization of microbial-assisted SR9AgNPs and encourages future studies to extend these conclusions to other relevant crops under field conditions.
Detection Methods for Pine Wilt Disease: A Comprehensive Review
Authors: Tahir Sana , Hassan Syed Shaheer , Yang Lu , Ma Miaomiao , Li Chenghao
Published: October 2024

Pine wilt disease (PWD), caused by the nematode Bursaphelenchus xylophilus, is a highly destructive forest disease that necessitates rapid and precise identification for effective management and control. This study evaluates various detection methods for PWD, including morphological diagnosis, molecular techniques, and remote sensing. While traditional methods are economical, they are limited by their inability to detect subtle or early changes and require considerable time and expertise. To overcome these challenges, this study emphasizes advanced molecular approaches such as real-time polymerase chain reaction (RT-PCR), droplet digital PCR (ddPCR), and loop-mediated isothermal amplification (LAMP) coupled with CRISPR/Cas12a, which offer fast and accurate pathogen detection. Additionally, DNA barcoding and microarrays facilitate species identification, and proteomics can provide insights into infection-specific protein signatures. The study also highlights remote sensing technologies, including satellite imagery and unmanned aerial vehicle (UAV)-based hyperspectral analysis, for their capability to monitor PWD by detecting asymptomatic diseases through changes in the spectral signatures of trees. Future research should focus on combining traditional and innovative techniques, refining visual inspection processes, developing rapid and portable diagnostic tools for field application, and exploring the potential of volatile organic compound analysis and machine learning algorithms for early disease detection. Integrating diverse methods and adopting innovative technologies are crucial to effectively control this lethal forest disease.
Tracking the Role of Faults on Mudstone Caprock Seals: A Case Study from Beier Depression, Hailar Basin, NE China
Authors: Liu Xin , Li Yuexiang , Yang Linlin , He Taohua , Zhao Ya , Zeng Qianghao , He Jiayi , Fu Guang
Published: October 2024

To study the oil and gas enrichment characteristics of the reservoir rocks in the second Member of the Nantun Formation (N2) of the F1 fault in the Beier Depression, this research focuses on the mechanism of shortening the sealing time of the regional mudstone cap due to faults and the factors influencing the sealing duration. The period during which the regional mudstone cap seal began is determined by analyzing the relationship between the diagenetic index of the regional mudstone cap and its underlying reservoir rocks and time. This relationship between the rock-formation index and time helps establish the onset of regional mudstone cap seal, and from this, the index of shortening time due to faults is derived. A research framework to study the sealing time shortening of regional mudstone cap seal caused by a fault was developed, which was further applied to analyze the relationship between the fault-induced shortening time of the seal in the lower of the first Member of the Damoguaihe Formation section (D1x) of the Beier Depression and hydrocarbon concentrations in the N2 Formation. The results show that the F1 fault at measurement points 1–4, 6, and 9–11 reduced the blocking time of the regional mudstone cap in D1x to 100%, hindering hydrocarbon accumulation and preservation in the N2. Conversely, the F1 fault at measurement points 5, 7, 8, and 12–15 reduces the blocking time of the regional mudstone cap in the D1x by 37–99%, which is more conducive to hydrocarbon accumulation and preservation in N2, resulting in positive oil and gas shows. Based on the test results, a discussion on the feasibility, applicability, and limitations of the new method is conducted, yielding the following conclusions: (1) The relationship between oil and gas indications in the reservoir rocks of the Nan’er Member confirms the feasibility of the new method. The research findings of the new method on the F1 fault align with current oil and gas exploration realities, indicating its potential use in studying the degree to which faults shorten the sealing time of regional mudstone caprocks. (2) The new method is primarily applicable to the study of the modification effects of tensile normal faults on regional mudstone caprocks and their impact on oil and gas sealing capacities. However, its application to other types of faults may have limitations. (3) The new method is mainly suitable for caprocks dominated by mudstone. When studying other types of caprocks, such as carbonate rocks, evaporites, igneous rocks, and metamorphic rocks, different research methods and technical means are required. These findings provide valuable insights for oil and gas exploration efforts near fault zones.
Continuous Fixed Bed Bioreactor for the Degradation of Textile Dyes: Phytotoxicity Assessment
Authors: Cherif Sonia , Rezzaz-Yazid Hynda , Ayachine Salima , Toukal Imene , Boudechiche Noreddine , Belmedani Mohamed , Djelal Hayet , Sadaoui Zahra
Published: October 2024

This study explores a novel bioremediation approach using a continuous upflow fixed bed bioreactor with date pedicels as a biosupport material. Date pedicels offer a dual advantage: providing microbial support and potentially acting as a biostimulant due to their inherent nutrients. This research is divided into two phases: with and without microbial introduction. The bioreactor’s efficiency in removing two common textile dyes, RB19 and DR227, was evaluated under various conditions: fixed bed high, the effect of the initial concentration of the pollutant, and recycling the RB19 solution within the bioreactor. Optimization studies revealed an 83% removal yield of RB19 dye with an initial pollutant concentration of 100 mg·L−1 using activated sludge as inoculum. The bioreactor developed its own bacterial consortium without initial inoculation. Microscopic analysis confirmed the presence of a diverse microbial community, including protozoa (Aspidisca and Paramecium), nematodes, and diatoms. The bioreactor exhibited efficient removal of RB19 across a range of initial concentrations (20–100 mg/L) with similar removal efficiencies (around 65%). Interestingly, the removal efficiency for DR227 was concentration-dependent. The bioreactor demonstrated the ability to enhance the biodegradability of treated RB19 solutions. Phytotoxicity tests using watercress and lettuce seeds revealed no negative impacts on plant growth. SEM and FTIR analyses were conducted to examine the biosupport material before and after biotreatment.
A Novel First-Order Kinetic Model for Simultaneous Anaerobic–Aerobic Degradation of Municipal Solid Waste in Landfills
Authors: Peng Ming-Qing , Chen Tian-Hao , Jin Taohui , Su Yi-Cong , Luo Sheng-Tao , Xu Hui
Published: October 2024

A first-order kinetic model for the simultaneous anaerobic–aerobic degradation of municipal solid waste (MSW) is presented in the study. The model incorporates the effect of oxygen concentration on anaerobic degradation, enabling the coexistence of anaerobic and aerobic processes within specific oxygen ranges. The model can thoroughly consider the impacts of temperature, moisture content, oxygen concentration, and free air space (FAS) on the degradation rates of five substrates, i.e., holocellulose, non-cellulosic sugars, proteins, lipids, and lignin. The model was successfully verified against two experimental results. The sequential model underestimates both compression strain and degradation ratio, with peak underestimation ratios of 8.7% and 9.2%, respectively. Using the simultaneous model, the effects of anaerobic age, temperature, and aeration rate on landfill aerobic remediation efficacy are quantitatively assessed. Two evaluation criteria, namely the advance rate of aerobic remediation stabilization time (Rt) and the degradation rate after 100 days of aerobic remediation (λ100a), are adopted. The results indicate the following: (1) Rt is more sensitive to anaerobic age and temperature, while λ100a is more affected by anaerobic age and aeration rate; (2) under optimal conditions, Rt and λ100a can reach 86.3% and 70.9%, respectively. The present model provides a crucial theoretical framework for evaluating aerobic remediation effectiveness in both anaerobic sanitary landfills and informal landfills, offering valuable insights for practical implementation and management.
Microstructure Characteristics and Elevated-Temperature Wear Mechanism of FeCoCrNiAl High-Entropy Alloy Prepared by Laser Cladding
Authors: Gao Yali , Bai Sicheng , Kou Guangpeng , Jiang Shan , Liu Yu , Zhang Dongdong
Published: October 2024

This paper investigated the FeCoCrNiAl high-entropy alloy on H13 steel, prepared using laser cladding, to improve the elevated-temperature wear resistance of the alloy. The results revealed that FCC and BCC phases, in terms of the coating, produced a large dislocation density. The coating exhibited a columnar and equiaxed crystal microstructure. With the comprehensive effects of fine-grain strengthening, solid solution strengthening, and dislocation strengthening, the average hardness of the coating (500 HV0.1) was improved by 150% compared with that of H13 steel (200 HV0.1). The wear experiments were conducted at 623 K, 723 K, and 823 K. Compared with H13 steel, the wear volume of the coating decreased by 59.20%, 70.79%, and 78.20% under different temperatures. The wear forms impacting the coating were mainly abrasive wear and oxidation wear. However, H13 steel presented adhesive wear and fatigue wear, in addition to abrasive wear and oxidation wear.
Study on the Influence Law of Micro-Scale Abrasive Wear on a Wind Turbine Brake Pad
Authors: Zhang Shengfang , Jin Lu , Yin Jian , Sha Zhihua , Ma Fujian , Yang Dapeng , Liu Yu
Published: October 2024

The hard particles in the copper-based powder metallurgic material of a brake pad for a wind turbine brake falls off and presses into the surface of the brake disc to form abrasive particles under high-speed and heavy-load working conditions. The presence of abrasive particles will produce abrasive wear with micro-scratch and micro-scribe on the copper-based material of the brake pad. The critical scratch depth effect in the abrasive wear process is proposed based on the critical depth effect of the metal removal process at the micro-scale. The abrasive wear is divided into two types: scratch wear and scratch wear, which is proposed according to the comparison of the actual scratch depth and the critical scratch depth. The range of braking speeds and friction coefficients in abrasive wear is determined by the recommended parameters of the disc brake. The ABAQUS2020 software is used to simulate and analyze the micro-scale abrasive wear of a brake pad. The brake strain/stress curves of the brake pad under different brake speeds and friction coefficients are compared and analyzed for two abrasive wear types based on the range of braking parameters, and the key factors affecting abrasive wear are proposed.
Unveiling the Power of Surfactant-Based Carbon Dots: Ultrasensitive Detection of Cadmium in Tap and Drinking Water Samples
Authors: Al-Meer Saeed , Al-Saad Khalid , Aledamat Reem , El-Shafie Ahmed S. , El-Azazy Marwa
Published: October 2024

This study introduces a novel approach for transforming the cationic surfactant, cetyltrimethylammonium bromide (CTAB), into fluorescent carbon dots (CDs) capable of detecting cadmium ions at ultralow concentrations. The current approach involves preparing CDs through hydrothermal process at various pH levels. The CDs synthesized using pH 10, CTAB-CDs-10, exhibited the highest fluorescence quantum yield (QY), 14.22%. UV-Vis spectroscopy helped identify specific peaks between 210 and 300 nm, corresponding to the π–π* transitions of the aromatic C=C bonds. Transmission electron microscopic (TEM) analysis verified the uniform spherical morphology with a particle size < 2.45 nm. FT-IR analysis confirmed the presence of C=C stretching vibrations. The Box–Behnken (BB) Design was used to reconnoiter the influence of three variables on the response parameter: the F0/F ratio. The best performance could be achieved at a pH of 9, after only 300 s, and a temperature of 50 °C. The developed CTAB-CDs-based nanoprobe showed an ON–OFF behavior when came in contact with cadmium (II) and demonstrated high sensitivity with a limit of detection as low as 0.06 µM (0.007 ppm) over a wide linear range of 2–103 µM. Validation tests confirmed the applicability of the CTAB-CDs-based nanoprobe for detecting cadmium (II) in tap and drinking waters with high accuracy and precision.
Investigation of the Influence of Cutter Geometry on the Cutting Forces in Soft–Hard Composite Ground by Tunnel Boring Machine Cutters
Authors: Wang Qinshan , Xue Hongpan , Yang Mingwen , Li Xiaojie , Liu Congsheng , Zhao Shisen
Published: October 2024

Tunnel Boring Machines (TBMs) are integral to modern underground engineering construction, offering enhanced safety and efficiency. However, TBMs often face challenges in complex geological conditions, such as composite strata, resulting in reduced advancement speed and increased cutter wear. This study investigates the rock-breaking characteristics of TBM disc cutters in composite strata through numerical simulations using the Particle Flow Code (PFC) 5.0 software. Focusing on the Jinan Metro Line 6, the research analyzes cutter forces, rock crack propagation, and the impact of cutter edge shapes on rock-breaking efficiency. The discrete element method (DEM) is employed to simulate microscopic behaviors of rocks, providing insights into crack formation, expansion, and failure. This study’s findings reveal that cutter design and operational parameters can significantly influence cutter lifespan and efficiency. By modifying cutter spacing and penetration depth, enhancing rock-breaking efficiency, and grouting softer layers, TBMs can maintain effective excavation in composite strata. The study establishes a comprehensive understanding of the interplay between TBM cutters and complex geological conditions, offering actionable strategies to enhance TBM performance and mitigate cutter damage.
Multiple Reaction Monitoring–Mass Spectrometric Immunoassay Analysis of Parathyroid Hormone Fragments with Vitamin D Deficiency in Patients with Diabetes Mellitus
Authors: Benabdelkamel Hicham , Nimer Refat M. , Masood Afshan , Al Mogren Maha , Abdel Rahman Anas M. , Alfadda Assim A.
Published: October 2024

Current immunoassay techniques for analyzing clinically relevant parathyroid hormone (PTH) circulating fragments cannot distinguish microheterogeneity among structurally similar molecular species. This hinders the identification of molecular species and the capture of target analyte information. Since structural modifications are important in disease pathways, mass spectrometry can detect, identify, and quantify heterogeneous ligands captured by antibodies. We aimed to create a sensitive and selective multiple reaction monitoring–mass spectrometric immunoassay analysis (MRM-MSIA)-based method for detecting and quantifying PTH fragments or proteoforms for clinical research. Our study established MRM transitions using triple-quadrupole tandem mass spectrometry for the signature peptides of five PTH fragments. This method was validated according to FDA guidelines, employing the mass spectrometric immunoassay (MSIA) protocol to bolster detection selectivity and sensitivity. This validated approach was applied by analyzing samples from type 2 diabetes mellitus (T2DM) patients with and without vitamin D deficiency. We found serum PTH fragments associated with vitamin D deficiency in patients with and without T2DM. We developed and validated the MRM-MSIA technique specifically designed for the detection and quantification (amino acid (aa38–44), (aa45–51), and (aa65–75)) of these fragments associated with vitamin D deficiency and T2DM. This study is the first to accurately quantify plasma PTH fragments using MRM-MSIA, demonstrating its potential for clinical diagnostics.
Palaeoecological Conditions in the South-Eastern and Western Baltic Sea during the Last Millennium
Authors: Ponomarenko Ekaterina , Pugacheva Tatiana , Kuleshova Liubov
Published: October 2024

We present the reconstruction of palaeoenvironmental conditions in the Gdansk, Bornholm, and Arkona Basins of the Baltic Sea over the last millennium. A multiproxy study (including geochemical, XRF, grain size, AMS, and micropalaeontological analyses) of five short sediment cores was performed. The relative age of the sediments was determined based on the Pb distribution along the sediment sequences, as radiocarbon dating has resulted in an excessively old age. The retrieved cores cover two comparable warm periods, the Medieval Climate Anomaly and the Modern Warm Period, for which the increase in surface water productivity was reconstructed. Notably, the production of diatoms was higher during the colder periods (the Dark Ages and Little Ice Age), but this was also the case within the Modern Warm Period. In the Gdansk Basin, the initial salinity increase during the Littorina transgression started after 7.7 cal. a BP. The increased inflow activity was reconstructed during the Medieval Climate Anomaly, even in the Gdansk Basin, despite, in general, very low foraminiferal amounts and diversity. The strongly positive North Atlantic Oscillation Index during this period led to the prevalence of westerly winds over the Baltic region and stronger saltwater intrusions. In the recent sediments, the reconstructed inflow frequency demonstrates a variability against the reduction trend, and a general decline compared to the Medieval Climate Anomaly is seen.
A French Jesuit in China: The Case of André Yverneau 1948–1951
Authors: Baycroft Timothy Pickard
Published: October 2024

During the many centuries of interaction and exchange between China and Europe, one of the most complex and ambiguous relationships was that of the Catholic Church and its missionaries in China. On one hand, they contributed to and can be seen as a part of the European imperial project of world colonisation, but on the other hand, they were instrumental in sharing and exchanging knowledge, as well as creating schools and other institutions in the places they created missions. At the same time, attempts were being made within the Catholic Church to promote the development of a Chinese clergy, although this issue remained divisive. This article examines these complex relationships through the eyes of a French Jesuit, André Yverneau, who was in China between 1948 and 1951 and who left a collection of letters back to his family describing these years. His experiences, observations, reactions and attitudes towards China and the mission are presented and analysed in order to re-evaluate some of the main debates surrounding the mission in China in the mid-twentieth century: education, language, indigenisation, and politics, both internal to the Catholic Church and with its relations in China.
Faith Inside an Immanent Frame
Authors: Sharkey Paul
Published: October 2024

Those who are charged with the responsibility of governing, leading or teaching in Catholic schools at this time are challenged by questions which go to the heart of their school’s mission. How is it possible for the mission of the Catholic school to be realised in a culture that is increasingly secularising? What is the secularising context and how is religious belief still possible today? These are questions of profound significance also for the families who seek a Catholic education for their children. Charles Taylor’s analysis of our secular age provides a foundation for addressing these questions as do findings from the Enhancing Catholic School Identity (ECSI) research. Whilst the secularising context is sometimes painted as the enemy of Catholic education, it is presented here as being the context in which Catholic schools must realise their mission and this cultural context, like any cultural context, has elements which support the mission and elements which impede it. The following key concepts from Taylor’s analysis are reviewed because of their relevance for Catholic schools: the Expressivist Age, the Cross-Pressured context and the Immanent Frame. The Post-Critical Belief Scale from the ECSI research is also reviewed, as a key finding is that Post-Critical Belief is the only viable option for faith in a secularising context.
Post-Extractivism and Bioeconomy: An Experimental Analysis of Combustion and Pyrolysis Processes as Alternatives to Add Value to Agro-Residues (Coffee Husks) Generated in Farmer Cooperatives of the Ecuadorian Amazon
Authors: Salgado Mario A. Heredia , Säumel Ina , Tarelho Luís A. C.
Published: October 2024

A post-extractivist development model for communities in the Amazon that is not based on non-renewable resource extraction demands the study and demonstration, in the field, of alternative economic activities that add value to currently generated residual biomass. Following the principles of bioeconomy, this study presents an experimental analysis of a retort burner and a pilot-scale auger-type pyrolysis reactor used to convert coffee husks generated in a collection and post-harvesting center of a farmer’s cooperative into thermal energy and biochar, respectively. This study shows that coffee husks, whether used as feedstock for combustion or pyrolysis processes, can supply the thermal energy required by the post-harvesting processes. The combustion or pyrolysis of coffee husks avoids its accumulation and decomposition while replacing fossil fuels used in post-harvesting operations, reducing costs and making farmers independent of fossil fuel subsidies. Unlike combustion (11,029.4 mg/Nm3), the CO concentration in the flue gas during the pyrolysis process was 458.3 mg/Nm3, which is below the eco-design standard of 500 mg/Nm3. According to the European Biochar Certificate, carbon content (67.4 wt%) and H/Corg, O/Corg (0.6 and 0.1, respectively) are within the typical values of biochars used for soil amendment and carbon sequestration. Nonetheless, the concentration of polycyclic aromatic hydrocarbons must be assessed to fully regard this material as biochar. Finally, further studies are required to assess the ability of cooperatives to generate and trade carbon credits linked with the application of biochar in their cropping systems.
Separation and Characterization of Wenjin Tongluo San Essential Oil with a Comprehensive Chromatographic Separation
Authors: Wang Chaoyue , Han Xionggao , Zuo Guanglei , Feng Jinghui
Published: October 2024

The essential oil components of traditional Chinese medicine in-hospital preparation were complex, and one-dimensional chromatographic separation was difficult to completely separate them due to the limited peak capacity. This study was carried out to establish a comprehensive two-dimensional chromatographic separation and analysis method based on countercurrent chromatography (CCC) and gas chromatography (GC). In this paper, we focused on the separation of the essential oil of the traditional Chinese medicine in-hospital preparation Wenjing Tongluo San by CCC × GC, and explored the orthogonality between the two chromatographic techniques to provide the new technical support for the screening of the active ingredients. A solvent system composed of n-hexane-ethyl acetate-methanol-water (9.5:0.5:8.5:1.5, v/v) was chosen for the first-dimensional CCC separation. All the fractions collected from CCC were transferred to GC for plotting two-dimensional contours map. The calculated capacity of the two-dimensional separation system exceeded 3000, which was 8 times more than that of the one-dimensional separation system. High orthogonality (r = 0.42) and spatial coverage factor (70.42%) were obtained. Meanwhile, all the fractions were identified by GC-MS. Our research provided a new methodology for separating essential oils in traditional Chinese medicine as well as an approach for evaluating the quality of traditional Chinese medicinal in-hospital preparation based on two-dimensional chromatographic fingerprints.
Quantitation of Copper Tripeptide in Cosmetics via Fabric Phase Sorptive Extraction Combined with Zwitterionic Hydrophilic Interaction Liquid Chromatography and UV/Vis Detection
Authors: Pingou Pantelitsa , Parla Anthi , Kabir Abuzar , Furton Kenneth G. , Samanidou Victoria , Papageorgiou Spyridon , Tsirivas Efthimios , Varvaresou Athanasia , Panderi Irene
Published: October 2024

The increasing demand for effective cosmetics has driven the development of innovative analytical techniques to ensure product quality. This work presents the development and validation of a zwitterionic hydrophilic interaction liquid chromatography method, coupled with ultraviolet detection, for the quantification of copper tripeptide in cosmetics. A novel protocol for sample preparation was developed using fabric phase sorptive extraction to extract the targeted analyte from the complex cosmetic cream matrix, followed by chromatographic separation on a ZIC®-pHILIC analytical column. A thorough investigation of the chromatographic behavior of the copper tripeptide on the HILIC column was performed during method development. The mobile phase consisted of 133 mM ammonium formate (pH 9, adjusted with ammonium hydroxide) and acetonitrile at a 40:60 (v/v) ratio, with a flow rate of 0.2 mL/min. A design of experiments (DOE) approach allowed precise adjustments to various factors influencing the extraction process, leading to the optimization of the fabric phase sorptive extraction protocol for copper tripeptide analysis. The method demonstrated excellent linearity over a concentration range of 0.002 to 0.005% w/w for copper tripeptide, with a correlation coefficient exceeding 0.998. The limits of detection and quantitation were 5.3 × 10−4% w/w and 2.0 × 10−3% w/w, respectively. The selectivity of the method was verified through successful separation of copper tripeptide from other cream components within 10 min, establishing its suitability for high-throughput quality control of cosmetic formulations.
Fostering Entrepreneurial Mindsets: Factors Shaping Student Intentions in a Challenging Economic Landscape
Authors: González-Prida Vicente , Sandoval-Trigos Jesús César , Moreno-Menéndez Fabricio Miguel , Gomez-Bernaola Kesler Osmar , Tello-Porras Diego Alonso , Pariona-Amaya Diana
Published: October 2024

This research aims at investigating factors affecting entrepreneurial intention among university students in Selva Central-Peru. The study seeks to explore how perceptions of behavioural and social norms, as well as entrepreneurs’ self-efficacy, impact entrepreneurial intentions among students. The research method used is a quantitative one, which in turn praises data obtained through questionnaires applied to 114 active students and analysed by statistical methods. Confirmed the positive influences of self-efficacy on entrepreneurial intention are six times larger than those of attitude and subjective norms, with 79.2% explained variance, respectively, in relation to the proposal model’s findings. Results showed that although the majority of students demonstrated medium to high entrepreneurship intentions, much scope remains for increasing this. These findings confirm just how critical it is to provide an educational context that supports entrepreneurial locus of control-building and, in so doing, draws on broader conversation within the education-occupational landscape. With this, the study highlights avenues to better leverage entrepreneurship as a pathway toward sustainable livelihoods and economic inclusion in an economically divided region.
A Return to Black Codes: How the Dobbs Decision Debilitated the 14th Amendment
Authors: Lewis Timothy Elijah
Published: October 2024

Substantive due process, drawn from the 14th Amendment, has been a consistent judicial doctrine for establishing and protecting the rights and liberties of Black citizens in the face of systemic racism. This prompts a question for political consideration and investigation: if the 14th Amendment is a constitutional equilibrium for rights Black citizens would otherwise not enjoy, could the rescission of a right decided and sustained by the 14th Amendment that is not racially explicit have negative racial implications for Black Americans? This study answers this question through an atheoretical case study on the ruling in Dobbs v. Jackson Women’s Health Organization, which overturned Roe v. Wade. This study finds that the ruling in Dobbs weakened the 14th Amendment by allowing parameters to be placed on substantive due process. Though the question before the Court was the constitutionality of Mississippi’s abortion law, the implications of weakening the 14th Amendment are that it allows for the legal and cultural revitalization of Black exclusion that existed under the Black Codes, which has already come to fruition in Students for Fair Admissions, Inc. v. President and Fellows of Harvard College and the end of affirmative action.