bluuebunny/crossref_metadata_2025 huggingface dataset:
Microphthalmia with linear skin defects (MLS) syndrome: Clinical, cytogenetic, and molecular characterization of 11 cases
Authors: Morleo Manuela , Pramparo Tiziano , Perone Lucia , Gregato Giuliana , Caignec Cedric Le , Mueller Robert F. , Ogata Tsutomu , Raas‐Rothschild Annick , de Blois Marie Christine , Wilson Louise C. , Zaidman Gerald , Zuffardi Orsetta , Ballabio Andrea , Franco Brunella
Published: July 2005

The microphthalmia with linear skin defects (MLS) syndrome (MIM 309801) is a severe and rare developmental disorder, which is inherited as an X‐linked dominant trait with male lethality. In the vast majority of patients, this syndrome is associated with terminal deletion of the Xp22.3 region. Thirty‐five cases have been described to date in the literature since the first description of the syndrome in the early 1990s. We now report on the clinical, cytogenetic, and molecular characterization of 11 patients, 7 of whom have not been described previously. Seven of these patients have chromosomal abnormalities of the short arm of the X‐chromosome, which were characterized and defined by fluorescence in situ hybridization (FISH) analysis. Intriguingly, one of the patients displays an interstitial Xp22.3 deletion, which to the best of our knowledge is the first reported for this condition. Finally we report on the identification and molecular characterization of four cases with clinical features of MLS but apparently normal karyotypes, verified by FISH analysis using genomic clones spanning the MLS minimal critical region, and with genome‐wide analysis using a 1 Mb resolution BAC microarray. These patients made it possible to undertake mutation screening of candidate genes and may prove critical for the identification of the gene responsible for this challenging and intriguing genetic disease. © 2005 Wiley‐Liss, Inc.
Characterization of a familial balanced rec(13) in a child with mild MR and his half‐sibling with two structurally rearranged chromosomes 13
Authors: Mehra S. , Christ L. , Jeng L. , Zinn A. B. , Schwartz S.
Published: July 2005

In this report, we describe a 7‐year‐old child with mild mental retardation, developmental delay, and learning disabilities. His karyotype contained a rearrangement of chromosome 13, which appeared to include a duplication of 13q31‐qter and a deletion of 13p12‐pter regions. The chromosomal origin of the additional material was confirmed by fluorescence in situ hybridization (FISH) using a whole chromosome painting probe specific for chromosome 13. Family studies showed that his mother carried a balanced inversion of chromosome 13 and that his half‐brother carried the balanced pericentric inversion of chromosome 13 from his mother as well as another structural rearrangement involving chromosome 13 presumably from his father. The findings from this study suggested that the proband's abnormal 13 resulted from an unbalanced crossing‐over between the normal and maternal inverted chromosome 13. © 2005 Wiley‐Liss, Inc.
Seasonal influence on the onset of idiopathic inflammatory myopathies in serologically defined groups
Authors: Sarkar Kakali , Weinberg Clarice R. , Oddis Chester V. , Medsger Jr. Thomas A. , Plotz Paul H. , Reveille John D. , Arnett Frank C. , Targoff Ira N. , Genth Ekkehard , Love Lori A. , Miller Frederick W.
Published: July 2005

Objective

To assess possible seasonal patterns in the onset of polymyositis (PM) and dermatomyositis (DM).

Methods

The study group comprised 503 patients who met the criteria for probable or definite PM or DM and for whom detailed data on the time of myositis onset were available. Statistical analyses were performed using a Poisson model that assessed associations of ethnicity, sex, autoantibody presence, and month of onset of muscle weakness.

Results

There were no significant seasonal patterns of disease onset in myositis patients as a whole or in the total PM or DM populations. Significant seasonal associations were present, however, in the serologically defined groups. In the 131 patients with antisynthetase autoantibodies who were categorized as non‐black, myositis onset peaked in March–April (P = 0.03). Among the antisynthetase‐positive patients, the association was predominantly in those with PM (n = 85; P = 0.05) and in men (n = 51; P = 0.042). Patients with anti–signal recognition particle autoantibodies, however, did not have a significant seasonal onset, which is in contrast to previous findings. Patients without myositis‐specific autoantibodies showed a significant peak in summer, with myositis onset in June–July (n = 252; P = 0.03); this seasonal association was significant in women (n = 182; P = 0.005), whereas there was no seasonal pattern in men (P = 0.9).

Conclusion

These findings, in conjunction with other data, suggest that diverse environmental agents, acting upon different immunogenetic backgrounds, result in distinct immune responses and clinical syndromes in the idiopathic inflammatory myopathies. Our results emphasize the importance of considering more homogeneous disease groups, based on clinicopathologic features, immune responses, ethnicity, and sex, when attempting to decipher the pathogeneses of autoimmune disorders.
The First Sodium Uranyl Chromate, Na4[(UO2)(CrO4)3]: Synthesis and Crystal Structure Determination.
Authors: Krivovichev Sergey V. , Burns Peter C.
Published: July 2005

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New Odorless Method for the Corey—Kim and Swern Oxidations Utilizing Dodecyl Methyl Sulfide (Dod‐S‐Me).
Authors: Ohsugi Shin‐ichi , Nishide Kiyoharu , Oono Keiji , Okuyama Kazunori , Fudesaka Masato , Kodama Sumiaki , Node Manabu
Published: July 2005

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NaBH4‐Mediated Facile Reduction of Esters of Baylis—Hillman Adducts: An Efficient Approach to Substituted Propane‐1,3‐diols.
Authors: Patra Arundhati , Batra Sanjay , Bhaduri Amiya P.
Published: July 2005

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An Expedient Synthesis of Allylic/Secondary Bromides from Dehydration of Tertiary‐β‐bromo Alcohols.
Authors: Bettadaiah B. K. , Srinivas P.
Published: July 2005

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Aluminum Enolates via Retroaldol Reaction: Catalytic Tandem Aldol‐Transfer—Tischtschenko Reaction of Aldehydes with Aldol Adducts of Ketones to Ketones.
Authors: Simpura Ilkka , Nevalainen Vesa
Published: July 2005

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Synthesis and Affinity for Serotonin and Dopamine Transporters of Some Benzophenone Oxime Ether Derivatives.
Authors: Lapucci Annalina , Nencetti Susanna , Demontis Gian Carlo
Published: July 2005

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Stereospecific Dearomatizing Cyclization of Tertiary α‐Amidoorganolithiums.
Authors: Clayden Jonathan , Knowles Faye E. , Menet Christel J.
Published: July 2005

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1,2‐Dithiolan‐3‐ones and Derivatives Structurally Related to Leinamycin. Synthesis and Biological Evaluation.
Authors: Salvetti Raul , Martinetti Giovanni , Ubiali Daniela , Pregnolato Massimo , Pagani Giuseppe
Published: July 2005

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Preparation of β‐Fluoro‐ and β,β‐Difluoro‐histidinols.
Authors: Dolensky Bohumil , Narayanan Jayan , Kirk Kenneth L.
Published: July 2005

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Lanthanide(III)‐Catalyzed Multicomponent Aza‐Diels—Alder Reaction of Aliphatic N‐Arylaldimines with Cyclopentadiene.
Authors: Powell David A. , Batey Robert A.
Published: July 2005

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Benzoazepine Derivative as Potent Antagonists of the Glycine Binding Site Associated to the NMDA Receptor.
Authors: Di Fabio Romano , et al. et al.
Published: July 2005

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Highly Diastereoselective Synthesis of Arylglycine Derivatives via TFA‐Promoted Friedel—Crafts Reactions of Phenols with Cyclic Glyoxylate Imines.
Authors: Chen Yong‐Jun , Lei Fei , Liu Li , Wang Dong
Published: July 2005

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Mild Regeneration of the Carboxylic Group of Amino Acid Alkyl Esters by Aqueous Methanolic Sodium Hydrogen Carbonate via 5‐Oxazolidinones.
Authors: Allevi Pietro , Anastasia Mario
Published: July 2005

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Bioactive Flavonoids of Tanacetum parthenium Revisited.
Authors: Long Christophe , Sauleau Pierre , David Bruno , Lavaud Catherine , Cassabois Valerie , Ausseil Frederic , Massiot Georges
Published: July 2005

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Formation of Quaternary Stereocenters by Copper‐Catalyzed Michael Reactions with L‐Valine Amides as Auxiliaries.
Authors: Christoffers Jens
Published: July 2005

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α‐Halo‐ and α‐Alkoxyvinylgermanes
Authors: Spivey A. C. , Diaper C. M.
Published: July 2005

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Versatility of the Titanium(IV)—Porphyrin Reagent for Determining Hydrogen Peroxide
Authors: Takamura Kiyoko , Matsubara Chiyo
Published: July 2005

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Crystal Structure of High Temperature Phase and Ionic Conductivity Mechanism of CuHgSX (X: Cl, Br).
Authors: Moro'oka Masakazu , Ohki Hiroshi , Yamada Koji , Okuda Tsutomu
Published: July 2005

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Thermal Stability of Lithium Nickel Oxide Derivatives. Part 1. LixNi1.02O2 and LixNi0.89Al0.16O2 (x = 0.50 and 0.30)
Authors: Guilmard M. , Croguennec L. , Denux D. , Delmas C.
Published: July 2005

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Phase Diagram of KF—InF3 System.
Authors: Chen Rong , Zhang Qiyun
Published: July 2005

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1‐[2‐(4‐Nitrophenoxy)acetyl]pyrrolidin‐2‐one: An Antiamnesic Agent
Authors: Thamotharan S. , Parthasarathi V. , Malik R. , Jindal D. P. , Piplani P. , Linden Anthony
Published: July 2005

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One‐Step Stereocontrol of Three Contiguous Stereogenic Centers in Acyclic Systems: The Tuning Effect of an Additive in a Tandem Asymmetric Michael Addition and Meerwein—Ponndorf—Verley Reduction.
Authors: Nishide Kiyoharu , Ozeki Minoru , Kunishige Hideaki , Shigeta Yukihiro , Patra Pranab K. , Hagimoto Yuri , Node Manabu
Published: July 2005

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Synthesis of Spiro and Fused Five Membered N‐Heterocycles from Alkylidenephosphoranes.
Authors: Abdou Wafaa M. , Salem Mounir A. I. , Sediek Ashraf A.
Published: July 2005

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Palladium‐Catalyzed Conjugate Addition of Organosiloxanes to α,β‐Unsaturated Carbonyl Compounds and Nitroalkenes.
Authors: Denmark Scott E. , Amishiro Nobuyoshi
Published: July 2005

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Two Carbon Homologated α,β‐Unsaturated Aldehydes from Alcohols Using the in situ Oxidation—Wittig Reaction.
Authors: Reid Mark , Rowe David J. , Taylor Richard J. K.
Published: July 2005

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Deprotection of 1,3‐Oxathiolanes to Carbonyl Compounds with Montmorillonite K10.
Authors: Chauhan S. M. S. , Kumar Anil , Sahoo B. B.
Published: July 2005

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1,2,5,6‐Tetra‐O‐benzyl‐D‐mannitol Derivatives as Novel HIV Protease Inhibitors.
Authors: Bouzide Abderrahim , Sauve Gilles , Sevigny Guy , Yelle Jocelyn
Published: July 2005

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(Z)‐1‐Aryl‐1‐haloalkenes as Intermediates in the Vilsmeier Haloformylation of Aryl Ketones.
Authors: Lilienkampf Annamaria , Johansson Mikael P. , Waehaelae Kristiina
Published: July 2005

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A Facile Conversion of Aromatic Esters to Amides by Using Lithium Amide under Mild Reaction Condition.
Authors: Deka Dibakar C. , Purkayastha Biswajit , Paul Maumita
Published: July 2005

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Efficient Synthesis of Biindenylidene Derivatives via a Domino‐Heck‐Type Double Cyclization of Diaryldienynes.
Authors: Rahman S. M. Abdur , Sonoda Motohiro , Itahashi Kayo , Tobe Yoshito
Published: July 2005

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3‐Cyanoindole‐Based Inhibitors of Inosine Monophosphate Dehydrogenase: Synthesis and Initial Structure—Activity Relationships.
Authors: Dhar T. G. Murali , Iwanowicz Edwin J. , et al. et al.
Published: July 2005

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Chemical Reactivity of 3‐Aryl‐5‐methyl‐1,3,4‐oxadiazolin‐2‐ones Towards Nitrogen Nucleophiles. Part 1. One‐Pot Ring Conversion of 3‐Aryl‐5‐methyl‐1,3,4‐oxadiazolin‐2‐ones into 4‐Amino‐2‐aryl‐5‐methyl‐2,4‐dihydro‐3H‐1,2,4‐triazol‐3‐ones.
Authors: Kavali Jyothi R. , Kotresh O. , Badami Bharati V.
Published: July 2005

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Coumarin Synthesis via Knoevenagel Condensation in Moisture Stable Room Temperature Ionic Liquids.
Authors: Bao Weiliang , Wang Zhiming , Li Yuxia
Published: July 2005

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Sequential Amination/Annulation/Aromatization Reaction of Carbonyl Compounds and Propargylamine: A New One‐Pot Approach to Functionalized Pyridines.
Authors: Abbiati Giorgio , Arcadi Antonio , Bianchi Gabriele , Di Giuseppe Sabrina , Marinelli Fabio , Rossi Elisabetta
Published: July 2005

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Ruthenium‐Catalyzed Oxidative Coupling and Cyclization Between 2‐Aminobenzyl Alcohol and Secondary Alcohols Leading to Quinolines.
Authors: Cho Chan Sik , Kim Bok Tae , Choi Heung‐Jin , Kim Tae‐Jeong , Shim Sang Chul
Published: July 2005

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A Sequential Pummerer—Diels—Alder Route for the Generation and Trapping of Furo[3,4‐c]pyridines: Synthesis of Heterocyclic Analogues of 1‐Arylnaphthalene Lignans.
Authors: Sarkar Tarun K. , Panda Niranjan , Basak Sankar
Published: July 2005

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Synthesis and Properties of N‐Alkyl‐6‐hydroxy‐5‐ (2,3,4,9‐tetrahydro‐1H‐β‐carbolin‐1‐yl)‐1H‐pyrimidine‐2,4‐diones and Their 2‐Thioanalogues.
Authors: Krasnov K. A. , Kartsev V. G. , Yurova M. N.
Published: July 2005

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Chemo‐enzymatic Synthesis of Levodropropizine.
Authors: Caselli Emilia , Tosi Giovanni , Forni Arrigo , Bucciarelli Maria , Prati Fabio
Published: July 2005

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Geraniol‐Derived 1,2,4‐Trioxanes with Potent in vivo Antimalarial Activity.
Authors: Singh Chandan , Gupta Nitin , Puri Sunil K.
Published: July 2005

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Design and Synthesis of Novel Chrysene‐Linked Pyrrolo[2,1‐c][1,4]‐benzodiazepine Hybrids as Potential DNA‐Binding Agents
Authors: Kamal Ahmed , Ramesh G. , Ramulu P. , Srinivas O. , Rehana Tasneem , Sheelu G.
Published: July 2005

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Stereoconvergent Preparation of Chiral Vinylsilanes by Cuprate Substitution of α‐Acetoxyallylsilanes. Application to the Synthesis of (S)‐(+)‐Bishomomanicone.
Authors: Guintchin Boris , Bienz Stefan
Published: July 2005

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Economic Preparation of 1,3‐Diphenyl‐1,3‐bis(diphenylphosphino)propane: A Versatile Chiral Diphosphine Ligand for Enantioselective Hydrogenations.
Authors: Dubrovina Natalia V. , Tararov Vitali I. , Monsees Axel , Kadyrov Renat , Fischer Christine , Boerner Armin
Published: July 2005

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Nitrogen Heterocyclic Bases as Catalysts for the Selective Synthesis of Symmetric P,P′‐Disubstituted Bisphosphonate Esters.
Authors: Stepinski Dominique C. , Hess Jacob N. , Herlinger Albert W.
Published: July 2005

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Doped Natural Phosphate: A New and Environmentally Friendly Catalyst in Nucleoside Synthesis
Authors: Rochdi A. , Taourirte M. , Redwane N. , Sebti S. , Engels J. W. , Lazrek H. B.
Published: July 2005

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Synthesis of Carbocyclic Analogues of Thymidine
Authors: Ludek O. R. , Meier C.
Published: July 2005

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One‐Pot Synthesis of an AZT Boranophosphate Conjugated with Tyrosine: A Potential Prodrug Candidate
Authors: Li Ping , Shaw Barbara Ramsay
Published: July 2005

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Synthesis of N‐(4‐Chlorobutyl)butanamide, a Chlorinated Amide Isolated from Aloe sabaea.
Authors: D'hooghe Matthias , Szakonyi Zsolt , Fueloep Ferenc , De Kimpe Norbert
Published: July 2005

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Organometallic Complexes of Rhodium
Authors: Ojima I. , Vu A. T. , Bonafoux D.
Published: July 2005

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Germanium Sulfides, Sulfoxides, and Related Compounds
Authors: Thornton P.
Published: July 2005

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Avoiding the Road Less Traveled: How the Topology of Enzyme—Substrate Complexes Can Dictate Product Selection
Authors: Eliot Andrew C. , Kirsch Jack F.
Published: July 2005

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Close Encounters of the Transient Kind: Protein Interactions in the Photosynthetic Redox Chain Investigated by NMR Spectroscopy
Authors: Crowley Peter B. , Ubbink Marcellus
Published: July 2005

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Cs6Mo27S31: A Novel Ternary Reduced Molybdenum Sulfide Containing Mo9 and Mo18 Clusters.
Authors: Picard S. , Salloum D. , Gougeon P. , Potel M.
Published: July 2005

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A Mechanistically Guided Design Leads to the Synthesis of an Efficient and Practical New Reagent for the Highly Enantioselective, Catalytic Dihydroxylation of Olefins.
Authors: Huang Jinkun , Corey E. J.
Published: July 2005

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Manganese/Bicarbonate‐Catalyzed Epoxidation of Lipophilic Alkenes with Hydrogen Peroxide in Ionic Liquids.
Authors: Tong Kit‐Ho , Wong Kwok‐Yin , Chan Tak Hang
Published: July 2005

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Reduction of Activated Conjugated Alkenes by the InCl3—NaBH4 Reagent System.
Authors: Ranu Brindaban C. , Samanta Sampak
Published: July 2005

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Pinacol Formation and Reduction of Aromatic Carbonyls with Magnesium—Methanol at Ambient Temperature.
Authors: Khurana Jitender M. , Bansal Geeti , Kukreja Gagan , Pandey Ravi R.
Published: July 2005

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Samarium Triiodide Catalyzed Deprotection of 1,1‐Diacetates.
Authors: Wang Xiaoxia , Zhang Yongmin
Published: July 2005

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Stereoselective Michael Addition of Trimethyl Aluminum to Nitro Acrylates: A Route to 2‐Methyl‐3‐amino Propionic Acid.
Authors: Eilitz Uwe , Lessmann Frank , Seidelmann Oliver , Wendisch Volkmar
Published: July 2005

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Asymmetric Synthesis of Chiral α‐Keto Esters via Grignard Addition to Oxalates.
Authors: MaGee David I. , Mallais Tammy C. , Eic Marijanna
Published: July 2005

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A Comparison of the Still—Gennari and Ando HWE‐Methodologies with α,β‐Unsaturated Aldehydes: Unexpected Results with Stannyl‐Substituted Systems.
Authors: Franci Xavier , Martina Sebastien L. X. , McGrady John E. , Webb Michael R. , Donald Craig , Taylor Richard J. K.
Published: July 2005

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Regioselective Reductive Demethoxylation of 3,4,5‐Trimethoxystilbenes.
Authors: Azzena Ugo , Dettori Giovanna , Idini Maria Vittoria , Pisano Luisa , Sechi Grazia
Published: July 2005

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Enantioselectivity of Transition Metal Catalyzed 1,3‐Cycloadditions of 2‐Diazocyclohexane‐1,3‐diones.
Authors: Mueller Paul , Allenbach Yves F. , Bernardinelli Gerald
Published: July 2005

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Synthesis of Dihydropyrrole and Pyrrole Derivatives by Radical Cyclization of γ,δ‐Unsaturated Ketone O‐Acetyloximes.
Authors: Yoshida Masayuki , Kitamura Mitsuru , Narasaka Koichi
Published: July 2005

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Synthesis of Substituted Oxindoles from α‐Chloroacetanilides via Palladium‐Catalyzed C—H Functionalization.
Authors: Hennessy Edward J. , Buchwald Stephen L.
Published: July 2005

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Synthesis, Characterization and Crystal Structures of Two 2‐Naphthyl Substituted Pyrazoles.
Authors: Yang Guang , Raptis Raphael G.
Published: July 2005

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Synthesis and Biological Evaluation of 4‐[(3‐Methyl‐3H‐imidazol‐4‐yl)‐(2‐phenylethynyl‐benzyloxy)methyl] ‐benzonitrile as Novel Farnesyltransferase Inhibitor.
Authors: Lin Nan‐Horng , Wang Le , Cohen Jerry , Gu Wen‐Zhen , Frost David , Zhang Haiying , Rosenberg Saul , Sham Hing
Published: July 2005

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A New Methodology of Intramolecular Hetero Diels—Alder Reaction with β‐Alkoxy‐Substituted Conjugated Nitroalkenes as Heterodienes: Stereoselective One‐Pot Synthesis of trans‐Fused Bicyclic γ‐Lactones.
Authors: Wada Eiji , Yoshinaga Masahiko
Published: July 2005

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Synthesis of 5‐(2‐Hydroxyethyl)‐1‐thia‐3,5,6,8‐tetraaza‐ and 1,3,5,6,8‐Pentaazaacenaphthylenes.
Authors: Tumkevicius S. , Sarakauskaite Z.
Published: July 2005

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Dichloroborane—Dioxane: An Exceptional Reagent for the Preparation of Alkenyl‐ and Alkylboronic Acids.
Authors: Josyula Kanth V. B. , Gao Peng , Hewitt Chris
Published: July 2005

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Synthesis, Spectral and Antimicrobial Evaluation of Some New 8‐Membered Phosphorus Heterocyclic Compounds.
Authors: Kumar K. Ananda , Reddy C. Suresh , Reddy C. Devendranath
Published: July 2005

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Efficient and Direct Synthesis of Saccharidic 1,2‐Ethylidenes, Orthoesters, and Glycals from Peracetylated Sugars via in situ Generation of Glycosyl Iodides with I2/Et3SiH.
Authors: Adinolfi Matteo , Iadonisi Alfonso , Ravida Alessandra , Schiattarella Marialuisa
Published: July 2005

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A Convenient Method for the Synthesis of 2‐(β‐D‐Glycopyranosylthio) Pyridines.
Authors: Attia Adel M. E. , El‐Shehawy Ashraf A.
Published: July 2005

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Selective Metalation of 6‐Methylpurines: Synthesis of 6‐Fluoromethylpurines and Related Nucleosides
Authors: Hassan Abdalla E. A. , Parker William B. , Allan Paula W. , Montgomery John A. , Secrist John A. III
Published: July 2005

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Synthesis of New Homo and Heterodimers of 2′,3′‐Dideoxyinosine (ddI) Using Ester Linkages
Authors: Ait Mohamed L. , Taourirte M. , Rochdi A. , Lazrek H. B. , Vasseur J. J. , Engels J. W. , Pannecouque C. , De Clercq E.
Published: July 2005

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Deaza‐ and Deoxyadenosine Derivatives: Synthesis and Inhibition of Animal Viruses as Human Infection Models
Authors: Vittori Sauro , Salvatori Daniela , Volpini Rosaria , Vincenzetti Silvia , Vita Alberto , Taffi Sara , Costanzi Stefano , Lambertucci Catia , Cristalli Gloria
Published: July 2005

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Thionucleotides as Inhibitors of Ribonucleotide Reductase
Authors: Roy B. , Chambert S. , Lepoivre M. , Decout J.‐L.
Published: July 2005

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Synthesis and Antiviral Evaluation of 2′,3′‐Dideoxy‐2′‐fluoro‐3′‐C‐hydroxymethyl‐β‐D‐arabinofuranosyl Pyrimidine Nucleosides
Authors: Hassan Abdalla E. A. , Pai Balakrina S. , Lostia Stefania , Stuyver Lieven , Otto Michael J. , Schinazi Raymond F. , Watanabe Kyoichi A.
Published: July 2005

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Investigations of Nucleoside H‐Phosphonamidate in the Design of Nucleotide Prodrug
Authors: Egron D. , Imbach J.‐L. , Gosselin G. , Aubertin A.‐M. , Perigaud C.
Published: July 2005

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Carbon Nanotubes for Adaptive Structures
Authors: Muehle Stefan , Monner Hans P. , Wierach Peter
Published: July 2005

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Germanium Hydrides
Authors: Oshima K.
Published: July 2005

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Novel Chemistry of Indole in the Synthesis of Heterocycles
Authors: Gribble Gordon W.
Published: July 2005

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Nitropyridines: Synthesis and Reactions
Authors: Bakke Jan M.
Published: July 2005

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Electrophilic Substitution in Combinatorial and Solid‐Phase Synthesis
Authors: Hansel Jan‐Gerd , Jordan Stephan
Published: July 2005

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Radical Reactions in Combinatorial Chemistry
Authors: Ganesan A. , Sibi Mukund P.
Published: July 2005

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Titanium‐Mediated Syntheses of Cyclopropanols and Cyclopropylamines
Authors: de Meijere Armin , Kozhushkov Sergei I. , Savchenko Andrei I.
Published: July 2005

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Chiral Zirconium Catalysts for Enantioselective Synthesis
Authors: Hoveyda Amir H.
Published: July 2005

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Structure and Lattice Dynamics of NH4IO3×2HIO3 Crystal as Derived from IR, Raman and 127I NQR Data.
Authors: Barabash A. , Baran J. , Gavrilko T. , Puchkovskaya G. , Ratajczak H. , Tarnavski Yu.
Published: July 2005

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Synthesis of Homoallylic Chiral Tertiary Alcohols via Chelation‐Controlled Diastereoselective Nucleophilic Addition on α‐Alkoxyketones: Application for the Synthesis of the C1—C11 Subunit of 8‐epi‐Fostriecin.
Authors: Ramachandran P. Veeraraghavan , Liu Haipeng , Reddy M. Venkat Ram , Brown Herbert C.
Published: July 2005

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Copper‐Catalyzed Coupling of Amides and Carbamates with Vinyl Halides.
Authors: Jiang Lei , Job Gabriel E. , Klapars Artis , Buchwald Stephen L.
Published: July 2005

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A Novel Oxidative Reaction of 2‐Nitro‐1‐phenylpropane with Sodium Nitrite. A New Approach to Prepare 1‐Oximino‐1‐phenylacetone.
Authors: Ran Chongzhao , Yang Genjin , Wu Taizhi , Xie Meihua
Published: July 2005

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Regioselective Synthesis of 1,2,3‐Triazole Derivatives via 1,3‐Dipolar Cycloaddition Reactions in Water.
Authors: Wang Zhong‐Xia , Qin Hua‐Li
Published: July 2005

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Pericyclic Reaction of Ketenes with Cascade Reaction Products of Pyridine N‐Oxides and Dipolarophiles. X‐Ray Structures of the Adducts and Formation Mechanism.
Authors: Oiso Shigeru , Eto Masashi , Yoshitake Yasuyuki , Harano Kazunobu
Published: July 2005

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Gold Catalysis: Efficient Synthesis and Structural Assignment of Jungianol and epi‐Jungianol.
Authors: Hashmi A. Stephen K. , Ding Li , Bats Jan W. , Fischer Peter , Frey Wolfgang
Published: July 2005

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Fragmentation of Carbohydrate Anomeric Alkoxyl Radicals. A New Synthesis of Chiral β‐Iodo Azides, Vinyl Azides, and 2H‐Azirines.
Authors: Alonso‐Cruz Carmen R. , Kennedy Alan R. , Rodriguez Maria S. , Suarez Ernesto
Published: July 2005

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Diastereoselective Synthesis of 2‐Substituted‐piperidin‐4‐ones as Convenient Precursors for an Asymmetric Approach to Carbacephams.
Authors: Barco Achille , Baricordi Nikla , Benetti Simonetta , Biondini Gisella , De Risi Carmela , Pollini Gian Piero
Published: July 2005

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Morphosynthesis of Complex Inorganic Forms Using Pollen Grain Templates.
Authors: Hall Simon R. , Bolger Helen , Mann Stephen
Published: July 2005

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A Solvothermal Route to High‐Surface‐Area Nanostructured MoS2.
Authors: Berntsen Nicole , Gutjahr Tobias , Loeffler Lars , Gomm John R. , Seshadri Ram , Tremel Wolfgang
Published: July 2005

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Nucleation—Elongation: A Mechanism for Cooperative Supramolecular Polymerization
Authors: Zhao Dahui , Moore Jeffrey S.
Published: July 2005

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Acylstannanes (Including S, Se, and Te Analogues)
Authors: Wyatt P. B.
Published: July 2005

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Theoretical Methods for the Simulation of Nucleic Acids
Authors: Orozco Modesto , Perez Alberto , Noy Agnes , Luque F. Javier
Published: July 2005

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Lignin. Structural Organization and Fractal Properties
Authors: Karmanov A. P. , Monakov Yu B.
Published: July 2005

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Amidate Complexes of Titanium and Zirconium: A New Class of Tunable Precatalysts for the Hydroamination of Alkynes.
Authors: Li Chunyu , Thomson Robert K. , Gillon Bronwyn , Patrick Brian O. , Schafer Laurel L.
Published: July 2005

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Stereospecific and Efficient Alkynylation at the More Hindered Carbon of Trisubstituted Epoxides.
Authors: Zhao Hongda , Pagenkopf Brian L.
Published: July 2005

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Electrochemical Formation of Methoxy‐ and Cyano(phenylazo)alkanes from Aldehyde and Ketone Phenylhydrazones.
Authors: Okimoto Mitsuhiro , Takahashi Yukio , Kakuchi Toyoji
Published: July 2005

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Ferroelectric Phase Transition in the Whitlockite‐Type Ca9Fe(PO4)7; Crystal Structure of the Paraelectric Phase at 923 K.
Authors: Lazoryak Bogdan I. , Morozov Vladimir A. , Belik Alexei A. , Stefanovich Sergey Yu. , Grebenev Vadim V. , Leonidov Il'ya A. , Mitberg Edward B. , Davydov Sergey A. , Lebedev Oleg I. , Van Tendeloo Gustaaf
Published: July 2005

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β‐LiMoO2(AsO4).
Authors: Hajji Mounir , Zid Mohamed Faouzi , Driss Ahmed , Jouini Tahar
Published: July 2005

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Synthesis and Characterization of an Organically‐Templated Zincophosphite: [C6H16N2] ×Zn3(HPO3)4.
Authors: Fu Wensheng , Shi Zhan , Li Guagnhua , Zhang Dong , Dong Wenjun , Chen Xiaobo , Feng Shouhua
Published: July 2005

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Reduction of Carbonyl Compounds by Lanthanide Metal/2‐Propanol: In situ Generation of Samarium Isopropyloxide for Stereoselective Meerwein—Ponndorf—Verley Reduction.
Authors: Fukuzawa Shin‐ichi , Nakano Narihito , Saitoh Takahide
Published: July 2005

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Synthesis of Carbo‐ and Heterobiaryls by Intermolecular Radical Addition of Aryl Bromides into Aromatic Solvents.
Authors: Nunez Araceli , Sanchez Aranzazu , Burgos Carolina , Alvarez‐Builla Julio
Published: July 2005

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Coupling Reactions of Hydralazine with Amino Acids and Their Adducts for Antihypertensive Activities.
Authors: Khattab Sherine N. , El Massry Abdel Moneim M. , El‐Faham Ayman , Bekhit Adnan A. , Amer Adel
Published: July 2005

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Studies on Reactions of 3‐Benzoyl‐4‐hydroxypyrido[3,2‐e]‐1,2‐thiazines with Primary Amines and N‐Methylhydrazine.
Authors: Malinka W. , Karczmarzyk Z. , Kaczmarz M. , Swiatek P. , Urbanczyk‐Lipkowska Z.
Published: July 2005

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Triene—Tricarbonyliron Complexes in Organic Synthesis
Authors: Ong Chi Wi , Lai Ming Chih
Published: July 2005

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In,out‐Isomerism of Phosphorus Bridgehead Cage Compounds
Authors: Bauer Ingmar , Habicher Wolf D.
Published: July 2005

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Function of the Antigen Transport Complex TAP in Cellular Immunity
Authors: Beismann‐Driemeyer Silke , Tampe Robert
Published: July 2005

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First‐Principles Calculations of the Elastic Properties of ZrC and ZrN.
Authors: Cheng Dayong , Wang Shaoqing , Ye Hengqiang
Published: July 2005

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Luminescent Properties of CaMgSi2O6‐Based Phosphors Co‐Doped with Different Rare Earth Ions.
Authors: Jiang L. , Chang C. , Mao D. , Feng C.
Published: July 2005

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Magnetic Structure of NdMn2‐xFexGe2 (x = 0.1 and 0.15) Compounds
Authors: Szytula A. , Duraj R. , Hernandez‐Velasco J. , Penc B. , Venturini G. , Wawrzynska E.
Published: July 2005

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Synthesis of LiNH2 Films by Vacuum Evaporation.
Authors: Nakamori Yuko , Yamagishi Tetsuto , Yokoyama Masaki , Orimo Shin‐ichi
Published: July 2005

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Some Structural and Photophysical Properties of Two Functional Double Oxides Bi2MTaO7 (M: Ga and In).
Authors: Wang Junhu , Zou Zhigang , Ye Jinhua
Published: July 2005

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Direct Catalytic Asymmetric Mannich‐Type Reaction of Hydroxyketone Using a Et2Zn/Linked‐BINOL Complex: Synthesis of Either anti‐ or syn‐β‐Amino Alcohols.
Authors: Matsunaga Shigeki , Yoshida Takamasa , Morimoto Hiroyuki , Kumagai Naoya , Shibasaki Masakatsu
Published: July 2005

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t‐BuOK‐Mediated Hydrophosphination of Functionalized Alkenes: A Novel Synthesis of Chiral P,N‐ and P,P‐Ligands.
Authors: Bunlaksananusorn Tanasri , Knochel Paul
Published: July 2005

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Michael Addition Reactions of Grignard Reagents to 2‐Halogenoacrylates: A Convenient Method for the Synthesis of Polysubstituted Cyclopropane Compounds.
Authors: Chen Chao , Xi Chanjuan , Jiang Yanfeng , Hong Xiaoyin
Published: July 2005

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A Convenient Method for the Oxidation of Aromatic Amines to Nitro Compounds Using Tetra‐n‐alkylammonium Bromates.
Authors: Das Satya Sandhya , Nath Utpal , Deb Dibakar , Das Pranab J.
Published: July 2005

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A New, Efficient and Simple Method for the Thionation of Ketones to Thioketones Using P4S10/Al2O3.
Authors: Polshettiwar Vivek , Kaushik M. P.
Published: July 2005

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A Simple Deprotection of Triflate Esters of Phenol Derivatives.
Authors: Ohgiya Tadaaki , Nishiyama Shigeru
Published: July 2005

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Methyltrioxorhenium‐Catalyzed Oxidation of Aromatic Aldoximes.
Authors: Cardona Francesca , Soldaini Gianluca , Goti Andrea
Published: July 2005

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Direct Synthesis of Protected Arylacetaldehydes by Palladium‐Tetraphosphine‐Catalyzed Arylation of Ethyleneglycol Vinylether.
Authors: Kondolff Isabelle , Doucet Henri , Santelli Maurice
Published: July 2005

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The Synthesis of Novel Benzocyclobutene Monomers Containing the Squaric Acid Unit.
Authors: Yang Jun‐xiao , Chen Wen , Zhu Fang‐hua , Su Xiao‐yu , Xie Ru‐gang , Li Bo , Zhang Lin
Published: July 2005

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Epoxydisilanes by Direct Double Silylation of Terminal Epoxides.
Authors: Hodgson David M. , Kirton Eirene H. M.
Published: July 2005

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Reactions of 2H‐Azirines with Carbenoids from Diazo Esters: Transformations of Novel Azirinium Ylides.
Authors: Khlebnikov Alexander F. , Novikov Mikhail S. , Amer Amer A.
Published: July 2005

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A Synthetic Entry to 2,3‐Fused Ring Indole Derivatives by Ring‐Closing Metathesis Reactions.
Authors: Bennasar M.‐Lluisa , Zulaica Ester , Tummers Sven
Published: July 2005

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Reaction of Bromo Dipoles with (Z)‐4‐(Arylmethylene)azol‐5‐ones. Substrate‐Controlled Synthesis of New Bromo‐Substituted Heterocyclic Spirans and Unusual N‐Benzoyl α‐Aminoacids.
Authors: Foti Francesco , Grassi Giovanni , Risitano Francesco , Rotondo Enrico , Zona Domenico
Published: July 2005

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Aryl 2,3‐Dibromopropyl Sulfones in S,N‐Tandem Heterocyclizations. New Synthesis of Benzimidazothiazolidines.
Authors: Shklyarenko A. A. , Yakovlev V. V. , Chistokletov V. N.
Published: July 2005

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Zirconium(IV) Chloride Mediated Cyclodehydration of 1,2‐Diacylhydrazines: A Convenient Synthesis of 2,5‐Diaryl 1,3,4‐Oxadiazoles.
Authors: Sharma G. V. M. , Begum Asra , Rakesh Rakesh , Krishna Palakodety Radha
Published: July 2005

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Inhibition of Monoamine Oxidases by Coumarin‐3‐acyl Derivatives: Biological Activity and Computational Study.
Authors: Chimenti Franco , Secci Daniela , Bolasco Adriana , Chimenti Paola , Granese Arianna , Befani Olivia , Turini Paola , Alcaro Stefano , Ortuso Francesco
Published: July 2005

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Amidine Derived 1,3‐Diazabuta‐1,3‐dienes as Potential Antibacterial and Antifungal Agents.
Authors: Bedi Preet M. S. , Mahajan Mohinder P. , Kapoor Vijay K.
Published: July 2005

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Direct Synthesis of 4‐Arylpiperidines via Palladium/Copper(I)‐Cocatalyzed Negishi Coupling of a 4‐Piperidylzinc Iodide with Aromatic Halides and Triflates.
Authors: Corley Edward G. , Conrad Karen , Murry Jerry A. , Savarin Cecile , Holko Justin , Boice Genevieve
Published: July 2005

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Highly Selective Synthesis of 2‐Substituted‐5‐hydroxy‐6‐oxo‐1,6‐dihydropyrimidine‐4‐carboxylic Acid Derivatives Using a Novel Protected Dihydroxyfumarate.
Authors: Dreher Spencer D. , Ikemoto Norihiro , Gresham Venita , Liu Jinchu , Dormer Peter G. , Balsells Jaume , Mathre David , Novak Thomas J. , Armstrong Joseph D. III
Published: July 2005

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Piperidine Carboxylic Acid Derivatives of 10H‐Pyrazino[2,3‐b][1,4]benzothiazine as Orally‐Active Adhesion Molecule Inhibitors.
Authors: Kaneko Toshihiko , et al. et al.
Published: July 2005

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An Expeditious Entry to Carbohydrate Derived Enynes and Ene‐Diynes via Sonogashira Coupling of Halo‐exo‐Glycals.
Authors: Gomez Ana M. , Pedregosa Ana , Barrio Aitor , Valverde Serafin , Lopez J. Cristobal
Published: July 2005

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Two New Haliclamines from the Arctic Sponge Haliclona viscosa
Authors: Volk Christian A. , Lippert Heike , Lichte Ellen , Koeck Matthias
Published: July 2005

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Syntheses of 10‐Oxo, 10α‐Hydroxy, and 10β‐Hydroxy Derivatives of a Potent ϰ‐Opioid Receptor Agonist, TRK‐820.
Authors: Horikiri Hiromasa , Hirano Noriyuki , Tanaka Yoichiro , Oishi Junji , Hatakeyama Hitoshi , Kawamura Kuniaki , Nagase Hiroshi
Published: July 2005

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The First Example of the Stereoselective Synthesis of 7β‐Carbamoyl‐4,5α‐epoxymorphinan via a Novel and Reactive γ‐Lactone.
Authors: Fujii Hideaki , Hirano Noriyuki , Uchiro Hiromi , Kawamura Kuniaki , Nagase Hiroshi
Published: July 2005

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A Novel Amide N‐Glycoside of Ansamitocins from Actinosynnema pretiosum.
Authors: Lu Chunhua , Bai Linquan , Shen Yuemao
Published: July 2005

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New Efficient Synthesis of Resorcinylic Macrolides via Ynolides: Establishment of Cycloproparadicicol as Synthetically Feasible Preclinical Anticancer Agent Based on Hsp90 as the Target.
Authors: Yang Zhi‐Qiang , Geng Xudong , Solit David , Pratilas Christine A. , Rosen Neal , Danishefsky Samuel J.
Published: July 2005

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Synthesis, NMR Spectra and X‐Ray Data of Chloro and Dichloro Derivatives of 3‐Hydroxy‐2‐phenylquinolin‐4(1H)‐ones and Their Cytostatic Activity.
Authors: Hradil Pavel , Krejci Petr , Hlavac Jan , Wiedermannova Iveta , Lycka Antonin , Bertolasi Valerio
Published: July 2005

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Nitrosyl and Oxo Complexes of Molybdenum
Authors: McCleverty J. A. , Ward M. D.
Published: July 2005

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Recent Synthetic Ion Channels and Pores
Authors: Matile Stefan , Som Abhigyan , Sorde Nathalie
Published: July 2005

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Studies in Heteroelement‐Based Synthesis
Authors: Vedejs Edwin
Published: July 2005

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Chiral Monodentate Phosphorus Ligands for Rhodium‐Catalyzed Asymmetric Hydrogenation
Authors: Jerphagnon Thomas , Renaud Jean‐Luc , Bruneau Christian
Published: July 2005

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Aluminum as an Electron Pool for Organic Synthesis. Multi‐Metal Redox‐Promoted Reactions
Authors: Tanaka Hideo , Kuroboshi Manabu
Published: July 2005

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New Trends in Ylide Chemistry
Authors: Taillefer Marc , Cristau Henri‐Jean
Published: July 2005

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The Photochemistry of Benzophenone
Authors: Shah Bipin , Neckers D. C.
Published: July 2005

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Molecular Encapsulation of Gases.
Authors: Rudkevich Dmitry M. , Leontiev Alexander V.
Published: July 2005

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Nerve growth factor sensitivity is broadly distributed among myenteric neurons of the rat colon
Authors: Lin Agueda , Lourenssen Sandra , Stanzel Roger D.P. , Blennerhassett Michael G.
Published: July 2005

Nerve growth factor (NGF) acts on the two‐receptor system of trkA and p75 to mediate neuroprotection and influence phenotype and function in the peripheral nervous system, but the effects of NGF on the enteric nervous system (ENS) are virtually unknown. To establish a basis for enteric responsiveness to NGF, we studied the presence and distribution of NGF‐sensitive receptors in the myenteric neurons of the normal rat colon and examined their activation via trkA phosphorylation. Fluorescent immunocytochemistry on wholemounts showed that the two NGF receptors were abundantly present in the ENS, with 71% of all neurons positive for trkA and 78% for p75. More thanr 60% of the myenteric neurons expressed both receptors, and exogenous application of NGF resulted in trkA phosphorylation, evidence for high NGF sensitivity within the ENS. trkA was co‐expressed with choline acetyltransferase (61% of trkA‐positive neurons), neuronal nitric oxide synthase (22%), or calbindin (10%), suggesting widespread potential for NGF action. We conclude that functional receptors for NGF are widely distributed among the diverse enteric phenotypes and argue for a novel NGF‐mediated regulatory system within the ENS. J. Comp. Neurol. 490:194–206, 2005. © 2005 Wiley‐Liss, Inc.
Performance of polyoxymethylene plastic (POM) as a component of a tissue engineering bioreactor
Authors: Penick Kitsie J. , Solchaga Luis A. , Berilla Jim A. , Welter Jean F.
Published: July 2005

Polyoxymethylene (POM, acetal homopolymer, polyacetal), commercialized as Delrin® by DuPont, is an engineering resin with mechanical properties that make it useful for the prototyping and manufacture of laboratory apparatus. These properties include excellent, “metal‐like,” machining characteristics and dimensional stability, as well as thermal stability, which allows steam sterilization. Historically, POM has been used widely, including as a surgical implant material. For these reasons, we have used this plastic as a media‐wetted component in a tissue‐engineering bioreactor, with good results. However, a study by LaIuppa et al.5 suggested that POM is unsuitable for use in a cell culture environment (LaIuppa et al. J Biomed Mater Res 1997;36:347–359). POM is based on the polymerization of formaldehyde, and, in addition, contains stabilizers and/or fillers. All of these could potentially be released into the medium, e.g., as formaldehyde or other thermal breakdown products, especially upon repeated autoclaving. The cited report thus appeared plausible, although contrary to our observations. In this study, we specifically assessed whether media conditioned by long‐term exposure to machined white POM had a negative effect on the proliferation and chondrogenic differentiation of human mesenchymal stem cells (MSCs). We selected this cell system, as cartilage tissue engineering is the primary application of our bioreactor system. The POM samples were steam‐autoclaved 1 to 20 times, to assess the possibility of any toxic thermal breakdown product release into the media. We found that MSCs did not attach directly to machined POM. Because cells that escape from the tissue construct cannot colonize the reactor and compete for nutrients, this is a desirable characteristic of a material used in a tissue‐engineering bioreactor. Furthermore, the use of POM‐conditioned media had no detectable impact on the proliferation rate of MSCs measured over a one‐week period; nor was any effect on chondrogenic differentiation observed at up to 3 weeks in culture. In summary, the use of POM as a culture medium‐wetted component appears to be innocuous, at least for human MSCs. The contrast of these findings to those of LaIuppa et al.5 may reflect a cell‐type specific sensitivity, or may be due to different handling of the material. © 2005 Wiley Periodicals, Inc. J Biomed Mater Res, 2005
A role for Runx2 in normal mammary gland and breast cancer bone metastasis
Authors: Shore Paul
Published: July 2005

The transcription factor Runx2 is essential for the formation of the skeleton. It has therefore primarily been considered as a specific regulator of bone genes. However, mice containing a LacZ insertion at the Runx2 locus also revealed expression in the nascent mammary epithelium. Reports of Runx2 expression in breast cancer cell lines, combined with the fact that breast cancers preferentially metastasise to bone, have also hinted at a potential role for Runx2 in the formation of bone metastasese. These initial observations have prompted further analysis of Runx2 function in mammary epithelial cells and recent findings have demonstrated that Runx2 does indeed contribute to the ability of metastatic breast cancer cell lines to form osteolytic bone lesions. In addition, evidence is accumulating that Runx2 has a role in the regulation of normal mammary gland gene expression and recent data demonstrate that it regulates transcription of the mammary gland‐specific gene, β‐casein. In this article I discuss recent advances that link Runx2 with normal mammary epithelial cell function and the development of bone metastasese in breast cancer. © 2005 Wiley‐Liss, Inc.