bluuebunny/crossref_metadata_2025 huggingface dataset:
Cáncer de colon ¿una sola entidad? Consideraciones sobre lateralidad en una institución oncológica colombiana 2001-2016
Authors: Villegas-Mejía Carlos Raúl , Chacón-Cardona José Arnoby , Villegas-Jaramillo Manuel , Villegas-Jaramillo Pedro
Published: March 2019

Introducción: ha sido sugerido que los cánceres del lado derecho e izquierdo del colon se presentan como entidades diferentes y como tal deberían ser abordados para su estudio, tratamiento y seguimiento. El propósito de esta investigación es hacer un análisis de pacientes con cáncer de colon según la lateralidad. Materiales y métodos: cohorte retrospectiva de 442 pacientes remitidos a Oncólogos del Occidente desde enero de 2001 a diciembre de 2016 con diagnóstico de cáncer de colon. Resultados: el 54 % de los casos fueron en colon izquierdo; sexo femenino 52 %; media de edad: 60,5 años en izquierdo y 62,5 en derecho; histología mucinosa (40 % vs 60 %), células en anillo de sello (40 % vs 60 %) y mal diferenciado (40 % vs 60 %); media de antígeno carcino-embrionario 51,7 vs 63,9 ngr/mL; ganglios resecados mayores o igual a 13 (41 % vs 59 %); presencia de obstrucción (22 % vs 18 %), compromiso de serosa (16 % vs 18 %) y ulceración (21 % vs 17 %). Se presentó recaída en 58 % vs 42 % y de ellos a hígado (33 % vs 23 %), pulmón (18 % vs 15 %) y carcinomatosis (15 % vs 14 %). La media de seguimiento global fue de 40,1 ± 39 con 38,3 meses para el lado izquierdo y 42,2 meses para el derecho y sobrevida a cinco años de 61 % vs 64 % para colon izquierdo y derecho, respectivamente. Conclusión: el patrón de ocurrencia del cáncer de colon según su lateralidad se presenta en el lado derecho en menor número, mayor edad, histología más agresiva, mayor nivel ganglionar, mayor compromiso de serosa, mayor seguimiento y similar sobrevida. Lo anterior, sumado al estado mutacional, podría ayudar a definir el manejo terapéutico inicial. Quedan aún muchas dudas para entender la diferencia en resultados no explicada solo basado en la lateralidad
Tumor neuroendocrino en un divertículo de Meckel
Authors: Flórez-Leguía María Katherine , Valencia José Julián , Sierra Sierra Sebastián
Published: March 2019

El divertículo de Meckel es la malformación congénita más frecuente del tracto gastrointestinal y puede complicarse por procesos inflamatorios, infecciosos o tumorales. La incidencia de tumores en un divertículo de Meckel es de 1,44 por cada 10 millones de personas al año. Reportamos un caso de obstrucción intestinal secundaria a un tumor neuroendocrino en un divertículo de Meckel y realizamos una revisión de la literatura sobre este tema.
Stents bronquiales bioabsorbibles y factores que afectan su velocidad de degradación
Authors: Colmenares-Roldán Gabriel Jaime , Hoyos Palacio Lina Marcela
Published: March 2019

Las causas que pueden conducir a la obstrucción de la vía aérea central pueden ser de origen funcional, por obstrucción de la luz, por lesión orgánica parietal o compresión extrínseca; a su vez, también pueden agruparse en obstrucciones malignas y no malignas. Cuando una obstrucción reduce el 50 % de la luz de la vía aérea causa síntomas debilitantes y es una de las indicaciones para implantar un stent bronquial. Los stents bronquiales actualmente disponibles son una solución incompleta para las obstrucciones de las vías aéreas. Por otra parte, un stent bronquial ideal debe cumplir con muchas características, tales como ser biocompatible, en muchos casos bioabsorbible, radio opaco, que no genere reacción inflamatoria, tener características similares a las de la vía aérea para disminuir la acumulación de secreciones, entre otras. Por esta razón los stents bronquiales bioabsorbibles se presentan como una alternativa atractiva que ofrece ciertas ventajas, aunque aún se encuentran en desarrollo. El presente artículo busca describir los avances alrededor de los stents bronquiales bioabsorbibles y los factores que afectan la degradación de los polímeros con los cuales se han fabricado.
Espasticidad como signo positivo de daño de motoneurona superior y su importancia en rehabilitación
Authors: Sepúlveda Paulina , Bacco José Luis , Cubillos Alejandro , Doussoulin Arlette
Published: March 2019

Introducción: la espasticidad, como signo clínico de daño de motoneurona superior, cobra gran importancia al momento de definir su impacto en el proceso rehabilitador. Los objetivos de esta revisión bibliográfica son: analizar la evolución de la espasticidad como concepto, describir los hallazgos actuales en relación con su fisiopatología y analizar su importancia en el proceso rehabilitador. Métodos: búsqueda bibliográfica durante el segundo semestre del 2017 en bases de datos Pubmed, Scielo, Cochrane y Google Académico, utilizando los términos MeSH: muscle spasticity, physiopathology y stroke. Los límites de búsqueda fueron: textos completos en idioma inglés y español, en humanos y publicados durante los últimos cinco años. Resultados: la fisiopatología de la espasticidad no es causada por un solo mecanismo, sino más bien una intrincada cadena de alteraciones en diferentes redes nerviosas interdependientes. Existiendo dos mecanismos principales: la alteración del control espinal y suprasegmentario y los cambios en las propiedades del sistema músculo-esquelético. Conclusión: la evidencia científica es amplia y aborda el concepto de espasticidad, sus implicancias fisiopatológicas y clínicas. Sin embargo, futuras investigaciones deberían orientar y apoyar las decisiones del equipo rehabilitador, en relación con el manejo clínico.
Removal of pharmaceuticals by a surface water treatment plant
Authors: Chauveheid Eric , Scholdis Sabine
Published: March 2019

Several pharmaceuticals were followed through a drinking water production process on the river Meuse. Tramadol and levetiracetam were the most common compounds while cytostatics were not detected. All compounds found at that intake point had an annual consumption greater than 90 mg/inhabitant. The tracer substance 1,2,3-benzotriazole allowed estimation of the maximal concentration of pharmaceuticals and the evolution profile for tramadol and sotalol. After pre-ozonation of raw water, most pharmaceuticals were completely removed, except levetiracetam and irbesartan, confirming the efficiency of this advanced oxidation process. Irbesartan and levetiracetam were completely removed by granular activated carbon filtration. Levetiracetam was the most reluctant compound. A conventional multi-barrier treatment combining ozone and activated carbon, already used for several decades before implementation in wastewater treatment, can completely remove most pharmaceuticals. Therefore, drinking water without any significant health-related amount of these pharmaceuticals can be produced from surface water.
Administration of information technologies of comparative subsidies
Authors: Obradovich Dragan , Denic Nebojsha
Published: March 2019

Information technology and its application become an increasingly important element in achieving competitiveness and efficient operation of modern companies. Unfortunately, business practice with the use of information technology significantly lags behind the business examples of successful companies in developed countries, as evidenced by the authors' research on the use of information technology in Serbian companies in early 2000.
English in the modern world and pronunciation problems
Authors: Salieva Dinara Abdurashidovna , Erkaiym Akbar kyzy , Asel Tolkunbek kyzy
Published: March 2019

This article examines the role of the English language in modern communication between people and how the problem of pronunciation affects perception. The author investigates the functions of intonation, describes the pronunciation peculiarities, offers methods on its effective mastering and renders difficulties that are usually faced by learners.
Inertia: scientific and world outlook aspects
Authors: Kulik Viktor Ivanovich , Kulik Ivan Viktorovich
Published: March 2019

Сomprehension of the concepts: «inertial condition of a body» and «inertial force» is the main aim of the article. Authors consider an inertial condition of a body or a system, as independent, autonomous, self-retaining and only internally dialectically changeable condition of the system living under the internal laws.
The content and types of research work of higher educational institutions students of Russia in the second half of the twentieth century and in modern conditions
Authors: Turchenko Liubov Grigorevna
Published: March 2019

The article analyzes the content and types of scientific research work of students of higher educational institutions of Russia in the second half of the 20th century and in modern conditions; the structure of research activity of students is determined, which ensures the effectiveness of the educational process and promotes the development of professional qualities.
Features of tax administration of the largest taxpayers
Authors: Darkina Yulia Aleksandrovna
Published: March 2019

The relevance of this article is due to the lack of improvement in tax legislation to account for the largest taxpayers, despite the fact that tax revenues account for more than half of all revenues to the budget. At the present stage, the tax administration system should simultaneously ensure: an increase in the level of tax collection, a reduction in the costs of taxpayers, the creation of convenient conditions for the performance of tax payment duties, and observance of the principle of equity. The article discusses the comparison of selection criteria for the largest taxpayers at the federal and regional levels.
Fine receptions of water coloring painting as a means of realization of creative ideas of future designers
Authors: Andreeva Olga Pimenovna , Akhmetova Svetlana Petrovna , Mikhailova Evelina Valerianovna
Published: March 2019

This article deals with the task of design education in the training of specialists who are ready to implement creative ideas in the design of environmental objects. It gives a detailed analysis discipline of academic painting. It is reported about the study of pictorial techniques, rules and patterns of academic painting, which are necessary when performing creative tasks. The stages of color design of the project are considered in detail, with the implementation of which various graphic techniques of watercolor painting are used.
One or many normativities?
Authors: Piekarski Michał
Published: March 2019

The aim of the present investigation is to sketch a new approach to analysing normativity. First (§1–2) I locate the problem of normativity in the landscape of contemporary philosophy and focus on the dispute between naturalism and antinaturalism. Then (§3) I discuss the so-called top-down approach to studying normativity, to which I oppose the bottom-up approach inspired by contemporary philosophy of science (§4). I see the integration of these approaches as enabling investigations of normative phenomena that do not reduce them to just one type of normativity (e.g. morality).
Efekt Knobe’a z perspektywy etyki tomistycznej. Problem porządków i kompetencji normatywnych
Authors: Waleszczyński Andrzej
Published: March 2019

W artykule podjęty zostaje problem interpretacji tzw. efektu Knobe’a, czyli pojawiającej się asymetrii w orzekaniu o intencjonalności wywołania skutku ubocznego. Występująca tendencja jest wyjaśniana „zabarwieniem moralnym” ocenianych czynów. Do tej pory dyskusje prowadzone były głównie wśród filozofów, którzy w znacznej mierze teorię moralności postrzegają jako etykę zasad. W artykule analizy rozszerzają dotychczasowe badania o nurt teleologiczny w etyce, a w szczególności o tradycję etyki tomistycznej. Dociekania filozoficzne koncentrują się na problemie porządków normatywnych, a w szczególności na dwóch typach poznania: informującego o ocenie moralnej i informującego o faktach. Zbadanie tego zagadnienia okazuje się pomocne nie tylko dla poszukiwań wyjaśnienia efektu Knobe’a, ale także lepszego zrozumienia samego zagadnienia intencjonalnego działania stosowanego w filozofii działania.    W rezultacie występowanie asymetrii w przypisywaniu intencjonalności działaniom autor tłumaczy mieszaniem porządków poznawczych, które można sprowadzić do zagadnienia kompetencji normatywnych. Przy analizowaniu efektu Knobe’a kompetencje normatywne odpowiadałyby za rozróżnianie zbieranych danych poznawczych oraz porządku „czysto informującego” od porządku oceniającego, odnoszącego się do norm lub wartości.
Emocje epistemiczne i normatywność albo o tym jak pokochać teorię znaczenia
Authors: Kozak Piotr
Published: March 2019

Celem artykułu jest omówienie zagadnienia treści i funkcji tzw. emocji epistemicznych, takich jak poczucie poprawności i niepoprawności. Twierdzę, że odpowiednie wyjaśnienie tych ostatnich powinno uwzględnić ich nie-metareprezentacyjny, niedykursywny i pozbawiony kryteriów charakter. W nawiązaniu do zagadnienia tzw. normatywności pierwotnej i problemu kierowania się regułą twierdzę, że możemy powiązać emocje epistemiczne z teorią znaczenia i argumentuję, że pewna klasa emocji epistemicznych, tj. poczucie poprawności i niepoprawności, stanowi warunek konieczny znaczenia.
The role of phenotypic and genetic basis of livestock selection for climate change adaptation and mitigation: A review
Authors: Tesema Zeleke , Taye Mengistie , Ayichew Desalegn
Published: March 2019

Livestock are not only suffering from climate change, but also contribute to climate change through the direct and indirect release of greenhouse gases (CH4, N2O and CO2). Characterization, identification and conservation of heat tolerant livestock breeds are basics for future challenging climate. Properties of the skin, hair, coat color, coat type, sweating, respiration capacity, tissue insulation, surface area relative to body weight, endocrinological profiles and metabolic heat production are important factors involved for heat tolerance. Selection based on these phenotypic characteristics is play indispensible for climate change adaptation and mitigation.  Molecular information is used to know the candidate gene for heat tolerance, their action, specific function and location on chromosomes thereby important for modification of gene and selection of heat tolerant breed and feed efficient animals. Genomic information also used to identify genes that regulated during a stressful event can lead to the identification of animals that are genetically superior for coping with stress. Marker assisted selection and proteomics may also be valuable in selection for secondary traits linked to adaptation, such as the genes for high levels of blood urea and ruminal ammonia in certain genotypes, associated with adaptation to low-quality C4 grasses. Scientific research results demonstrated that heat tolerance is heritable trait and variable between/within livestock breeds, thereby variation and heritability of the trait opens the window for selection of heat tolerant animals. Therefore, the combined genomic selection using genome wide DNA markers that predict tolerance to heat stress and phenotypic selection could be accelerated breeding of highly productive and heat tolerant livestock breeds. Further research should be conducted on characterization, identification of indigenous breeds at molecular level and on identification of responsible genes/genomic regions associated with thermoregulation, feed and production efficiency in order to develop suitable adaptive and mitigation strategies to counter environmental stresses.
MODELING OF LOADING BY INDUSTRIAL EXOSKELET
Authors: Yatsun S. F. , Antipov V. M. , Karlov A. E.
Published: March 2019

The article deals with the task of lifting a weight by a person using an exoskeleton. It is proposed to consider lifting in the form of three successive stages. A mathematical model of the exoskeleton, describing movement in various modes of movement, has been developed. The inverse task of kinematics was solved, which allows finding the rotation angles of the exoskeleton links at the preparatory stage. The method for determining the driving moments at the stages of lifting the load is proposed.
OPTICAL-ELECTRONIC DEVICE OF CALCULATION OF PARAMETERS OF VOLUME OBJECTS OF WORKING SCENE AT MULTIPLE SOURCES OF VIDEO DATA
Authors: Frolov M. M. , Truphanov M. I.
Published: March 2019

The paper considers approaches to the construction of a geographically distributed optical-electronic device, providing an analysis of significant and long working scenes in the interests of automating the processes of control and management of robotic tools in industrial assembly shops and warehouses. The principal difference of the proposed solution is the possibility of obtaining images of the analyzed objects using optical-electronic sensors located in different parts of the workspace to realize the function of binocular vision on a much larger area of the working scene compared to analogues. A distinctive novelty of the developed theoretical approach is the approach to binocular technical vision, which consists in iteratively performing calibration procedures for selected pairs of opticalelectronic sensors and the subsequent calculation of the spatial coordinates of the objects being analyzed using calibrated pairs of optical-electronic sensors. The results of image analysis from each of the optoelectronic sensors are used to accompany moving objects and analyze their motion paths in the working scene space. To implement the developed theoretical approaches, a modular optoelectronic device has been developed, consisting of two types of modules. The first type of module is a standalone opto-electronic module, which includes an opto-electronic sensor and means for processing and extracting primary features immediately upon receiving images for their subsequent analysis. The second type is a computational module that provides processing of primary data from a set of modules of the first type. Data transfer between device modules is provided via radio over a WiFi network. A distinctive feature of the developed device is the primary processing of images immediately upon their receipt and transmission over the radio channel of a small amount of data about the selected objects to the computing module, which performs the final stages of data processing and generates a set of parameters describing the characteristics and spatial coordinates of the objects found on the working scene for their further of use. Experimental studies were conducted on the developed simulation model, which confirmed the correctness of the developed theoretical approach and the possibility of its application in practice.
EXAMINATION OF FAILURES OF CONSTRUCTED WATER WELLS
Authors: Bredikhin V. V. , Akulshin A. A. , Los K. I.
Published: March 2019

The example of judicial construction and technical examination of the constructed water intake well in one of settlements is considered in this article. The analysis of failures occurred during the operation of the newly built water intake well was carried out. The point moments on the quality and timing of the work performed there are often disputable when putting objects into operation. If these questions cannot be resolved by mutual agreement of the parties, their decision is transferred to the courts, which appoint judicial construction and technical expertise. The type of judicial engineering and technical expertise, judicial construction and technical expertise plays an important and sometimes decisive role in legal proceedings, including the consideration of civil disputes in courts of General jurisdiction and arbitration courts. Judicial construction and technical expertise was appointed on the basis of the decision of the arbitration court for a new water intake well built in one of the settlements of the Kursk region. The reason for the appointment of the examination is that this well has ceased to provide the planned flow rate, and the produced water meet the quality requirements. Two main reasons led to the decline in the technological characteristics of the well and the deterioration of the quality of the produced water: the wrong choice of the pumping unit and the lack of a water tower on the network. The selected ECV 6-16-140 pump created excess pressure in the network, which was then reduced by the installed automation (frequency Converter), and accordingly the well flow rate decreased. The use of frequency converters is not always useful, but can even have a harmful effect on the operation of the water supply system. In addition to reducing the flow rate, the operation of the frequency Converter caused the combustion of several pumps operating in unacceptable modes. The work of the frequency Converter installed on the pump unit with overestimated characteristics led to the turbidity of the produced water, there was an uneven consumption of water from the well.
RECONSTRUCTION OF ARTESIAN WATER IN THE MANOR OF A. K. TOLSTOY
Authors: Akhremenko S. A. , Pytskaya M. S.
Published: March 2019

Currently, the issue of preservation and effective use of cultural heritage is relevant. Bryansk region has a significant number of valuable historical and cultural monuments. Almost every district is rich in unique places of interest, a special place among which is occupied by the estate. Within the framework of the concept of landscaping of the estate of Alexei Konstantinovich Tolstoy in the village of Krasny Rog, Pochepsky district, Bryansk region, together with the company "Bryanskpromburvod" were carried out field surveys, engineering-geological, hydrological surveys and other necessary activities in order to compile a pre-project proposal for the reconstruction of the source of artesian water, taking into account archival and bibliographic materials, with minor changes in view of the current state of the territory of the object of cultural heritage. Taking into account engineering-geological and hydrological researches, results of full-scale inspection of the territory, the technology of drilling of a well, necessary materials and the equipment for its arrangement is picked up. The article considers the issue of attracting tourists and vacationers to the source of artesian water in the estate of Alexei Konstantinovich Tolstoy. Above the source it is recommended to install a pump room for the release of water, in order to protect it from pollution, and perform it in the architectural style corresponding to the period of life of Alexei Konstantinovich Tolstoy in the estate. Historical and cultural heritage can act not only as a factor in the development of spiritual life, but also as one of the promising areas of economic development in the Bryansk region. The attractiveness of the Museum-estate increases the tourist attendance, and part of the funds can be used for the maintenance of cultural heritage.
IMPROVING THE EFFICIENCY OF THE PROCESS OF TECHNICAL OPERATION OF VEHICLES BY USING THE DISTANCE DIAGNOSTIC METHOD
Authors: Ageeva E. V. , Sabelnikov B. N. , Shcherbakov A. V. , Pykhtin A. I.
Published: March 2019

The current economic situation in the global fuel market leads to the fact that there is a rise in the cost of operating vehicles. All this makes the owners of such vehicles pay close attention to their optimal operation mode, which primarily depends on competent diagnosis of its components. Saving fuel-operating resources of a modern car directly depends on optimally adjusted parameters of operation of all components and assemblies of a car. The purpose of this work was to increase the efficiency of the process of technical operation of vehicles through the use of the method of remote diagnostics on the example of LLC POGA-1. The practice of using diagnostic tools demonstrates the possibilities of reducing operating costs. This is achieved due to an increase in the resources actually used, a decrease in the number of repairs and the saving of spare parts costs. Over the past years in the Russian Federation has been actively developing the field of freight. The largest share falls on road transport (67.7%). A significant proportion of the country's truck fleet is used as a commercial vehicle, which significantly complicates the procedure for timely diagnosis. Thus, in the event of a malfunction or error in the operation of a motor vehicle, the vehicle can be on a flight and there will not be a specialized service station within range of technical diagnostics of the truck to identify the causes of errors and / or malfunctions. The established problem finds its solution in the application of the method of remote diagnosis of commercial vehicles straight from the TO center, which is equipped with the necessary complex for diagnosing.
PRINCIPLES AND DESIGN TRENDS OF MODERN EDUCATIONAL SCHOOLS
Authors: Pozdnyakov A. L. , Pozdnyakova E. V. , Skripkina J. V. , Efanova T. A.
Published: March 2019

The article talks about the practice of designing and building modern secondary schools, as well as the need to rethink the material component of this process, a new look at the adoption of space-planning decisions of similar institutions, based on modern urban planning and typological requirements for the organization of educational work, including the existing level of architectural and urban science. The aim of the study is to analyze the principles and recommendations on the architectural and planning formation of secondary schools that correspond to the specifics of the modern educational process. The study examines the formation of architectural-planning and functional solutions for school buildings based on the search for new approaches in design. The analysis of the modern system of the educational process and its requirements in the development of a new spatial organization of the school environment. In addition to this, the existing structure of education in modern schools is considered, which may further affect the design, change the architectural quality and improve school buildings. It explains how the school space can make an educational sense and what it should be for it to become. The article deals with the problem of reforming the modern Russian school architecture, which stopped in its development at the Soviet stage, which includes most of the school buildings of standard construction. As a result, trends in the design of general education spaces were studied and the main problems encountered in the development of new plans in schools were identified and methods for their solutions were proposed. The necessity of introduction of the modular principle of designing schools with a fundamental difference from the standard building is shown. Each specific project may contain individuality both in visual perception and in the layout of the modules, functional meaning, scale.
Improved survival with remote monitoring in CRT-D recipients (Preprint)
Authors: Bogyi Peter , Vamos Mate , Bari Zsolt , Polgar Balazs , Muk Balazs , Nyolczas Noemi , Kiss Robert Gabor , Duray Gabor Zoltan
Published: March 2019

BACKGROUND

Remote monitoring is an established, guideline-recommended technology with unequivocal clinical benefits; however, its ability to improve survival is contradictory.

OBJECTIVE

The aim of our study was to investigate the effects of remote monitoring on mortality in an optimally treated heart failure patient population undergoing CRT-D implantation in a large-volume tertiary referral centre.

METHODS

The population of this single-centre, retrospective, observational study included 231 consecutive patients receiving CRT-D devices in the Medical Centre of the Hungarian Defence Forces (Budapest, Hungary) from January 2011 to June 2016. Clinical outcomes were compared between patients on remote monitoring and on conventional follow-up.

RESULTS

The average follow-up time was 28.4 ± 18.1 months. Patients on remote monitoring suffered more likely from atrial fibrillation, received heart failure management at our dedicated heart failure outpatient clinic more often, and had a slightly lower NYHA functional class. Crude all-cause mortality of remote-monitored patients was significantly lower compared to patients followed conventionally (HR: 0.368, 95% CI: 0.186-0.727, p=0.004). The survival benefit remained statistically significant after adjustment for important baseline parameters (adjusted HR: 0.361, 95% CI: 0.181-0.722, p=0.004)

CONCLUSIONS

In this current single-centre, retrospective study of optimally treated heart failure patients undergoing CRT-D implantation, the use of remote monitoring systems was associated with significantly better survival.
Engagement and Usability of a Cognitive Behavioral Therapy Mobile App Compared With Web-Based Cognitive Behavioral Therapy Among College Students: Randomized Heuristic Trial (Preprint)
Authors: Purkayastha Saptarshi , Addepally Siva Abhishek , Bucher Sherri
Published: March 2019

BACKGROUND

Recent evidence in mobile health has demonstrated that, in some cases, apps are an effective way to improve health care delivery. Health care interventions delivered via mobile technology have demonstrated both practicality and affordability. Lately, cognitive behavioral therapy (CBT) interventions delivered over the internet have also shown a meaningful impact on patients with anxiety and depression.

OBJECTIVE

Given the growing proliferation of smartphones and the trust in apps to support improved health behaviors and outcomes, we were interested in comparing a mobile app with Web-based methods for the delivery of CBT. This study aimed to compare the usability of a CBT mobile app called MoodTrainer with an evidence-based website called MoodGYM.

METHODS

We used convenience sampling to recruit 30 students from a large Midwestern university and randomly assigned them to either the MoodGYM or MoodTrainer user group. The trial period ran for 2 weeks, after which the students completed a self-assessment survey based on Nielsen heuristics. Statistical analysis was performed to compare the survey results from the 2 groups. We also compared the number of modules attempted or completed and the time spent on CBT strategies.

RESULTS

The results indicate that the MoodTrainer app received a higher usability score when compared with MoodGYM. Overall, 87% (13/15) of the participants felt that it was easy to navigate through the MoodTrainer app compared with 80% (12/15) of the MoodGYM participants. All MoodTrainer participants agreed that the app was easy to use and did not require any external assistance, whereas only 67% (10/15) had the same opinion for MoodGYM. Furthermore, 67% (10/15) of the MoodTrainer participants found that the navigation controls were easy to locate compared with 80% (12/15) of the MoodGYM participants. MoodTrainer users, on average, completed 2.5 modules compared with 1 module completed by MoodGYM users.

CONCLUSIONS

As among the first studies to directly compare the usability of a mobile app–based CBT with smartphone-specific features against a Web-based CBT, there is an opportunity for app-based CBT as, at least in our limited trial, it was more usable and engaging. The study was limited to evaluate usability only and not the clinical effectiveness of the app.
Telemedicine for Patients with Inflammatory Bowel Disease (TELE-IBD) Clinical Trial: Qualitative Assessment of Participants’ Perceptions of the TELE-IBD Intervention (Preprint)
Authors: Quinn Charlene C , Chard Sarah , Roth Erin G , Eckert J. Kevin , Russman Katharine M , Cross Raymond K
Published: March 2019

BACKGROUND

Inflammatory bowel diseases (IBD), comprising Crohn’s disease and ulcerative colitis, affects 1 to 3 million people in the United States. Telemedicine has shown promise in IBD. The objective of the parent study, TELE-IBD, was to compare disease activity and quality of life (QoL) in a one-year randomized clinical trial of IBD patients receiving telemedicine versus standard care. Treatment groups experienced improvements in disease activity and QoL but there was not significant differences between groups. Study adherence to the text-based intervention was less than the 80% of the targeted goal.

OBJECTIVE

To understand adherence to remote monitoring, the goal of this qualitative assessment was to obtain TELE-IBD trial participants’ perceptions of the TELE-IBD system, including their recommendations for future TELE-IBD monitoring.

METHODS

In the parent study, patients attending three tertiary referral centers with worsening IBD symptoms in the previous two years were eligible for randomization to remote monitoring via texts every other week (EOW), weekly (W) or standard care. Participants (n=348) were evenly enrolled in the treatment groups and 259 (74.4%) completed the study. For this study, a purposive sample of adherent (N=15) and non-adherent (N=14) patients was drawn from the TELE-IBD trial population. Adherence was defined as the completion of 80% or more of the W or EOW self-assessments. Semi-structured interviews conducted by phone surveyed 1) the strengths and benefits of TELE-IBD; 2) challenges associated with using TELE-IBD; and 3) how to improve the TELE-IBD intervention. Interviews were recorded, professionally transcribed, and coded based on a priori concepts and emergent themes with the aid of ATLAS.ti qualitative data analysis software.

RESULTS

Participants' discussions centered on three elements of the intervention: 1) self-assessment questions, 2) action plans, and 3) educational messages. Participants also commented on: text-based platform, depression and adherence, TELE-IBD system in place of office visit, and their recommendations for future TELE-IBD systems. Adherent and non-adherent participants prefer a flexible system that is personalized, including targeted education messages, and they perceive TELE-IBD as effective in facilitating IBD self-management.

CONCLUSIONS

Participants identified clear benefits to the TELE-IBD system, including obtaining a better understanding of the disease process, monitoring their symptoms, and feeling connected to their health care provider. Participants' perceptions obtained in this qualitative study will assist in improving the TELE-IBD system to be more responsive to patients with IBD.

CLINICALTRIAL

NCT01692743
Aktivitas fisik dengan penyakit jantung koroner di Indonesia
Authors: Setyaji Diyan Yunanto , Prabandari Yayi Suryo , Gunawan I Made Alit
Published: March 2019

Background: Coronary heart disease (CHD) is responsible for a substantial amount of early deaths, reduced quality of life and significant costs to the health and social care system. More than 3/4 CHD cases can prevented by lifestyle changes and focus on earlier risk factors management. Physical activity become a reference for the most important of primary and secondary prevention.Objective: To determine the relationship between physical activity and coronary heart disease in Indonesia.Method: This study used a cross-sectional design. Coronary heart disease’s history, physical activity, age, sex, economic status and consumption of fatty food were obtained from Basic Health Research (Riskesdas) 2013. Riskesdas 2013 used multistage cluster sampling. Subject in this study was 374.506 women and 347.823 men above 15 years old in Indonesia who answered the coronary heart disease questions which was selected purposively. Data was analyzed by using descriptive analysis, Chi-Square and multiple logistic regression.Results: Those who did not perform vigorous-intensity physical activity or who only did it less than 80 minutes per week had a higher prevalence of CHD than those who were more active  [2.63 (2.44-2.86); p=0.00].Conclusion: Physical activity had a significant association with CHD events in people above 15 years old in Indonesia.
PUBLICAÇÕES CIENTÍFICAS DAS ETNOCIÊNCIAS - CAMINHOS PASSADOS E FUTUROS
Authors: Tomchinsky Bernardo , Barros Flávio Bezerra , Corona-M Eduardo , Ming Lin Chau , Welch James R
Published: March 2019

Este debate entre editores de revistas científicas que publicam trabalhos nas áreas de etnobiologia e etnoecologia foi proposto para fomentar uma discussão a fim de compreender aspectos relacionados ao processo editorial e às tendências dentro das respectivas áreas. Participaram editores das revistas Ethnoscientia, Ethnobiology Letters, Etnobiología e Amazônica: revista de antropologia, que redigiram perguntas norteadoras aos demais colegas. A partir deste debate observamos que todos os quatro editores possuem posicionamentos semelhantes sobre diversos temas acerca da publicação de trabalhos científicos nas áreas de etnobiologia e etnoecologia. Fica claro que estas revistas não impõe nenhuma linha restritiva quanto aos tipos trabalhos publicados e compartilham grande preocupação quanto à qualidade geral dos trabalhos publicados, às questões éticas atreladas a eles, bem como o respeito à diversidade, autonomia e a participação ativa dos povos e comunidades tradicionais colaboradoras. Outro fator comum a estas publicações é a preocupação com a democratização e acessibilidade às revistas, questão que as fazem buscar diferentes estratégias para viabilizar o acesso dos autores e também dos leitores. 
Introducción al muestreo de poblaciones y comunidades microbiológicas
Authors: Casanova Zuñiga Dunny
Published: March 2019

Se identifican y comentan brevemente los principales tópicos de muestreo que pueden interesar a un investigador de poblaciones y comunidades microbiológicas naturales: definición de universo y unidades de estudio, determinación del tamaño de una muestra, definición de variables acerca de las cuales se desea efectuar estimaciones muestrales, factores de que depende la precisión de una estimación, diseños clásicos que otorgan alta “representatividad” a una muestra, importancia del azar en la selección muestral y limitaciones en las estimaciones proyectadas a partir de “miniunidades”
Les dermathophytes a Paris de sabouraud a nos jours
Authors: Badillet G.
Published: March 2019

Se efectúa una revisión de los dermatófitos aislados en Paris desde la época de Sabouraud a nuestros días, demostrándose los profundos cambios detectados desde el fin del siglo pasado. Los parásitos más activos como Trichophyton tonsurans y Microsporum audouinii, han casi desaparecido. Trichophyron ru brum. sin embargo, se ha propagado en forma fulgurante después del fin de la segunda guerra mundial, transformándose en el más frecuente parásito fúngico de la población de París, sobrepasando ampliamente a Trichophyton interdigitale. Epidermophyton jloecosum y Microspornm canis.La diversificación de especies se debe principalmente a la importante inmigración y a los paseos dominicales y vacionales del parisino a las zonas rurales.Se comenta la presencia de los diversos agentes fúngicos. sus variaciones y porcentajes según las caracteristicas clínicas de las lesiones.
Susceptibilidad "in vitro" de dermatofitos frente a Griseofulvina y Tolnaftato de sodio
Authors: Zaror L. , Otth L. , Pinedo M.
Published: March 2019

Se ha informado acerca de una evolución de la susceptibilidad de Griseofulvina frente a Dermatofitos.Por otra parte, desconociendo el comportamiento de las cepas de estos hongos aislados en nuestro medio, como también frente al Tolnaftato de Sodio se estudian las C.I.M de estas drogas por el Método de Chmel Louria.Se comparan estos dos antifúngicos, ya que muchas veces se utilizan como un tratamiento combinado. El 97,5% de las cepas estudiadas fue sensible a una concentración igual o inferior a 1,0 microgramos por ml. de Griseofulvina y el 96,6% a 0,16 microgramos por ml. de Tolnaftato de Sodio.El 97,5% de las cepas estudiadas fue sensible a una concentración igual o inferior a 10 microgramos de Griseofulvina y el 96,6% lo es frente a 0,16 microgramos o menos de Tolnaftato de Sodio.
Caracteres farmacológicos de las drogas antifúngicas empleadas en medicina
Authors: Negroni Ricardo
Published: March 2019

En la primera parte de este trabajo se comentan las características farmacológicas y los mecanismos de acción de drogas antifúngicas tales como Yoduros, Sulfamidas y Polienos del tipo de la Anfotericina B y Nistatina. Con la finalidad que el micólogo clínico o el médico no especializado conozca el manejo de estas drogas y pueda obtener una útil, simple y completa información
Thermophilous fungi isolated from the air at Pavia
Authors: Guglielminetti M. , Savino E.
Published: March 2019

Se presentan los resultados de un año de investigación sobre hongos termófilos en el aire de la ciudad de Pavia (Italia).Se detectan ocho especies, las más frecuentes son: Aspergillus fumigatus Fres., Thermomyces lanuginosus, Tsiklinsky, y Rhizomucor pusillus (Lindt) Schipper.
Hyphomycetes acuáticos de Magallanes (Chile)
Authors: Burgos E. Julio , Shearer Carola
Published: March 2019

En noviembre de 1982 se realizó una prospección de hongos acuáticos presentes en la península de Brunswick, en Magallanes (Chile). Desde esteros, ríos y lagunas se colectaron hojas sumergidas en descomposición, y muestras de la espuma formada. Los resultados de esta prospección indican ventajas y desventajas de ambos métodos de muestreo y la variedad y abundancia relativa de especies. Ellas son registradas por primera vez en esta zona austral de Chile, de las cuales, cinco son nuevas para Sudamérica. Según el análisis de la espuma, los conidios más abundantes corresponden a AIatospora  sp.2, Fontanospora eccentricum, Scorpiosporium minutum y Varicosporium delicatum.
Parasitación Pulmonar por Pseudallescheria Boydii
Authors: Salamanca F. Lucía , Retamal G. Clara , Galleguillos M. Fabián , Rodríguez Juan C. , Díaz J. M. C.
Published: March 2019

Se comunica tres casos de parasitación pulmonar por Pseudallescheria boyii en su fase anamorfa (Sc. apiospermum) en pacientes con daño estructural previo, dos de ellos por tuberculosis.En dos pacientes se aisló el hongo en expectoración; el suero de uno de ellos presentó varias bandas de precipitación en la DDA, CIE e IEF con el antígeno metabólico preparado con su propia cepa. Los sueros de los otros pacientes no reaccionaron.En el tercer paciente se observó el hongo al examen directo del trozo de pulmón obtenido en la lobectomía.Los tres pacientes presentaron hemoptisis a repetición, la que provocó la muerte en el primer caso y lobectomía de urgencia en el tercero.Se destaca el hecho que son los primeros casos de micosis pulmonar por Ps. boydii comunicados en nuestro país.
Microbiología y medio ambiente: los microorganismos como indicadores de contaminación
Authors: Campos Pardo Victoriano
Published: March 2019

Se efectuó una revisión de los microorganismos utilizados como indicadores en contaminación de aguas. Se analiza el papel que éstos desempeñan en los sistemas acuáticos, la presencia de patógenos en aguas contaminadas, y las características ideales que debe presentar un buen indicador.Finalmente se discuten los indicadores microbianos más utilizados, señalando las ventajas y desventajas de su aplicación.
Pemilihan Guru Berprestasi Menggunakan DSS (Decision Support System) Dengan Metode FMADM (Fuzzy Multiple Attribute Decission Making) Dan SAW (Simple Additive Weighting)
Authors: Suryati Suryati , Jauhari Zuraidah
Published: March 2019

Sistem pendukung keputusan (decision support systems) merupakan bagian dari sistem informasi berbasis komputer termasuk sistem berbasis pengetahuan/manajemen pengetahuan yang dipakai untuk mendukung pengambilan keputusan dalam suatu organisasi atau perusahaan. Guru adalah faktor pendidik yang paling penting dalam sebuah lembaga kependidikan. Dengan harapan seorang guru tidak hanya mengajar namun juga dapat memberikan pendidikan serta prestasi yang membanggakan bagi dirinya, siswa dan lembaga. Lembaga akan memberikan penghargaan atau reward pada guru yang berhasil tersebut. Kendalanya adalah lamanya waktu untuk menyeleksi guru-guru yang dianggap berprestasi. Berdasarkan permasalahan tersebut, maka perlu dikembangkan adanya sebuah perangkat lunak agar bisa melakukan tugas–tugas secara mandiri sehingga dapat meminimalisir terjadinya kesalahan data maupun mempercepat proses penyeleksian guru berprestasi. Metode yang digunakan adalah FMADM (FuzzyMultiple AtributDecision Making) dan SAW (Simple Additive Weighting). Penelitian ini membahas mengenai pengkajian, analisis dan pengembangan sebuah sistem penunjang keputusan menggunakan pencocokan profil yang bersifat mandiri supaya bisa membantu institusi atau lembaga untuk memberikan reward sebagai penghargaan atas prestasi dari guru pada institusi atau lembaga bersangkutan.
Penerapan Metode Certainty Factor Pada Diagnosa Penyakit Saraf Tulang Belakang
Authors: Sucipto Adi , Fernando Yusra , Borman Rohmat Indra , Mahmuda Nisa
Published: March 2019

Dalam menganalisa sebuah informasi dimungkinkan seorang pakar mengungkapkan informasi berupa pernyataan yang tidak pasti seperti mungkin, kemungkinan besar dan hampir pasti.Salah satu metode yang dapat digunakan dalam mengatasi ketidak pastian adalah metode certainty factor. Certainty factor merupakan  metode yang mendefinisikan ukuran kepastian terhadap fakta atau aturan untuk menggambarkan keyakinan seorang pakar terhadap masalah yang sedang dihadapi. Untuk membantu dan mempermudah masyarakat dalam mendiagnosa penyakit saraf tulang belakang dapat menerapkan metode certainty factor pada sistem pakar. Saraf bagian tulang belakang merupakan organ yang penting bagi manusia. Terbatas dan tidak meratanya dokter spesialis saraf tulang belakang di Indonesia mengakibatkan masyarakat kesulitan dalam mendiagnosa penyakit tersebut. Sistem pakar dapat membantu untuk diagnosa penyakit, dimana sistem ini untuk merekonstruksi keahlian dan penalaran kemampuan seorang pakar. Pada penelitian ini, certainty factor diimplementasikan pada aplikasi diagnosa penyakit saraf tulang belakang. Sistem diujicobakan pada sejumlah masukan, hasil pengujian didapatkan memberikan hasil sesuai dengan perhitungan manual. Hasil pengujian dengan uji coba pada sejumlah masukan yang dilakukan didapatkan bahwa pengujian memberikan hasil sesuai dengan perhitungan manual. Sedangkan pengujian akurasi kesesuaian dari data testing yang didapatkan oleh pakar dengan output sistempakar didapatkan hasil output yang sesuai sebanyak sebesar 90%.
Xenotransplantation: history, problems and development prospects
Authors: Gulyaev V. A. , Khubutiya M. Sh. , Novruzbekov M. S. , Mironov A. S. , Olisov O. D. , Lutsyk K. N. , Zhuravel S. V. , Magomedov K. M. , Akhmetshin R. B. , Yaremin B. I.
Published: March 2019

The paper reviews the milestones and prerequisites in the history of the emergence and development of xenotransplantation. The currently existing barriers (immunological, infectious, genetic, ethical, and regulatory) to the development of this organ and tissue transplantation type have been studied. Available data on theoretical research and experimental studies have been reviewed. The prospects for performing xenotransplantation in various combination of species have been assessed. The forms and variants of the xenograft rejection reaction have been described. Genetic engineering approaches to overcoming xenoimmunological incompatibility are described. An assessment is made of ways to overcome existing barriers and prospects for the further development of xenotransplantation as a scientific section of transplantology.