bluuebunny/crossref_metadata_2025 huggingface dataset:
TOPICAL TACROLIMUS 0.1% FOR TREATMENT OF CUTANEOUS MICROCYSTIC LYMPHATIC MALFORMATIONS
Authors: Salvia S.A. , Amore M.A. , Papendieck C.M.
Published: December 2021

Microcystic lymphatic malformations as described in the international literature form a subgroup of low-flow congenital vascular malformations (VM) resulting from irregular embryological development. Microcystic lesions normally manifest as an accumulation of lymph- and blood-filled vesicles that, when externalized, cause skin maceration with consequent pain and potential infection resulting in the impairment of the patient's quality of life. There is no consensus on a standardized algorithm nor clear guidelines for successful treatment of this type of lymphatic malformation, and treatment options employed often result in ambivalent and transient outcomes with a high rate of recurrence. The topical formulation of tacrolimus is a well-known FDA-approved anti-T cell agent that was recently identified as a potent activator of ALK1, which is involved in several processes and functions including angiogenesis. We investigated if topical administration of tacrolimus may be an effective therapy for directly targeting cutaneous microcystic lymphatic malformations as a complement to systemic treatment. The study enrolled four patients with cutaneous microcystic lymphatic malformations: three male (ages: 13, 15, 18) and one female (age: 30). Two of the patients presented lesions on their backs, one patient on the left hand and one on the left lower limb. All four patients received treatment with topical tacrolimus 0.1% twice a day for 10 weeks on a previously selected area for application. Weekly clinical follow-ups were conducted along with close physician-patient contact. All patients displayed a satisfactory response after treatment. Lymphorrhea and bleeding were stopped in all cases and the esthetic aspect of lesions improved in two patients. To date, all patients presented no clinically significant changes to the size or extension of the lesion. Topical tacrolimus treatment is a promising and reasonable option for microcystic lymphatic malformations. Our results encourage further exploration in larger populations with the consideration that it is a safe and effective alternative or complementary therapy to systemic treatment.
ISL NEWS
Authors: Editors The
Published: December 2021

2021 ISL News
Dampak Rasio Keuangan Dan Pandemi COVID-19 Terhadap Kinerja Keuangan
Authors: Nuryasman MN Villy,
Published: December 2021

This study has purpose to determine the effect of ratios on financial performance by using current ratios, quick ratios, dan debt to assets ratios as measuring instruments for the dependent variablesl and using return on assets as measuring instruments for independent variables. The population of the financial statements is PT Multisport Indonesia for the 2019-2021 period. The sampling technique is purposive sampling. The analytical methods to test the hypothesis is path analysis. Data processing using Eviews10 software. The result of the study found that current ratio had a significant positive effect on return on assets, the quick ratio had a significant negative effect on return on assets,  and the debt on assets ratio had an insignificant negative effect on return on assets.
PENGARUH MEDIA PENDINGIN PADA PROSES HARDENING MATERIAL BAJA S45C
Authors: Yuri Syaifudin , Djamil Sofyan , Lubis Sobron Yamin
Published: December 2021

Abstract: Hardening is the process of heating the steel to a temperature of austenite and then dyeing is done quickly, the process is carried out to improve the properties of steel hardness. The method used in this research using books and journal literature .The purpose of this study to determine the mechanical properties of the steel that is cooled by the cooling medium brine , oil, water and air in the cooling medium to the level of violence after the S45C steel is hardened in a hardening process and microstructure . The study starts from the cutting hardness test specimen with a diameter of 65 mm x 7 mm x 10 mm and impact test with a diameter of 10 mm x 10 mm x 55 mm . The results obtained hardness test salt water has the average value of hardness 95 BHN , the average value of hardness oli 89 BHN , the average value of water hardness 94 BHN , the average value of hardness air 87 BHN and hardness values without in hardening 88 BHN , impact test on the air has an average value 1.175 J/
PERANCANGAN DAN ANALISIS PEMBEBANAN GERGAJI RADIAL 4 ARAH
Authors: Wijaya Michael Wijaya , Utama Didi Widya , Halim Agus
Published: December 2021

Abstract: 4 ways hacksaw is one type of wood hacksaw, which has 4 arms wood hacksaw and connected by linkage, so that can make translation movement. This 4 ways hacksaw powered by 1,5 HP AC Motor. This 4 ways hacksaw design, performed modeling and construction load simulation was made and simulated by Autodesk Inventor Professional 2014 software. And also on this load simulation this product also had good strength and ability to receive the maximum load force. So it is safe to be use
ANALISIS KEMAMPUAN PROSES PELAPISAN POLYUREA PADA ACRYLIC DENGAN KETEBALAN TERTENTU TERHADAP SIFAT MEKANIK
Authors: Putra Jason Arie , Siahaan Erwin , Darmawan Steven
Published: December 2021

Abstract: Coating became quite common. The coating serves as a conduit of color and also to cover the base material. Polyurea coating is a new innovation in the field of industry, so far polyurea coatings are used to coat the walls of the building and also the roof of the building to tackle the problem of leakage. This study explains how large the influence of the Polyurea coatings to acrylic. In this study which is distinguished by variations in thickness 3mm acrylic, 5mm and 8mm. This study also discusses the tensile resilience and resistance to shock loads. The purpose of this study was to determine how much influence the Polyurea coatings by comparing with Polyurea acrylic coated and uncoated. As an example of the results obtained from tensile tests that 3mm acrylic coated and uncoated increased by 39.6% acrylic 5mm by 0.66% and 1.65% acrylic 8mm. Polyurea coatings can not deliver maximum results on specimens that have smooth surfaces, so that we can see that in every test carried downhill result.
OPTIMALISASI PARAMATER RESISTANCE SPOT WELDING UNTUK PENGELASAN TIGA TUMPUK LEMBAR BAJA SPCC
Authors: Wibisono Pradipta Satrio
Published: December 2021

In the automotive industry, the latest breakthroughs and innovations are strongly influenced bymaintaining and increasing production results so that the use and application of technology is anabsolute must, as is welding technology. Thin sheet-shaped components are found in many car bodies.One of the methods used in joining plate sheets is to use the resistance spot welding method, which is awelding process that is only carried out at a certain point using copper electrodes. In the welding method,maintaining quality in order to produce products and services that can meet the needs and expectationsof consumers related to the product's life time or service. SPCC steel (Cold Roller Stell Sheet) is one ofthe most widely used materials in car body welding applications. The characteristics and mechanicalproperties of SPCC steel from the results of the three-sheet welding were examined using the parametersof welding current, welding time, welding distance. The results showed that the increase in current wouldaffect the diameter of the electrode traces and the nuggets that were formed. The greater the current used,the larger the diameter of the trail, so that the optimum pull-shear load is at a current of 6.5 kA at adistance of 20mm with a value of 365.53 MPa, also the highest hardness value is in the nugget area witha hardness value of 595, 14 HVN at a current of 6.5 kA and from the results of measuring grain diameterin microstructural testing for the HAZ area the best at a welding current of 6.5 kA. Because the smallerthe weld grain diameter, the greater the strength of the weld joint. Then the data from the results of theshear-shear test are analyzed using the Taguchi method, and the most effective parameters in the tensilesheartest with a combination of A (6.5) B (1.5) C (15) and from the experimental results for tensile loads.slide obtained 397 MPa.
PENENTUAN KECEPATAN PEMOTONGAN EFEKTIF BERDASARKAN NILAI KEKASARAN PERMUKAAN MATERIAL AA-7075 PADA PROSES FACE MILLING
Authors: Lubis Sobron Y. , Rosehan Rosehan , Law Musa
Published: December 2021

During face milling machining, several machining parameters such as feed rate and cuttingspeed determine the surface quality of the workpiece produced by the process. The selection of the rightparameters will lead to the surface quality as planned. Therefore, to improve machining effectiveness, amethod is needed to determine the appropriate machining parameters to produce the desired surfacequality. This research was conducted using a milling machine, five variations of cutting speed and fivevariations of feed rate were used to cut the workpiece aluminum alloy 7075. After machining, the surfaceroughness was measured using a surface test. The surface roughness value is then substituted into thefeed rate equation and effective cutting speed. By finding effective cutting parameters, the machiningprocess will be more efficient and effective without using unnecessary resources. From the results of thestudy note that the development equation to determine the feed rate based on the value of surfaceroughness is ???? = 0,6????√???? ????????0.443mm/tooth. Development equation to determine the effective cutting speedbased on Surface roughness value is ???????? = 3.0686????????0.124 mm/min
Niemożliwa ale niezbędna? – wokół informacji historycznoliterackiej w szkole średniej
Authors: Kaniewski Jerzy
Published: December 2021

This text is about the methods, employed in schools, of putting high school students in touch with cultural tradition. My interest in this issue is connected to the recent appearance of meaning of the “historical and literary order” in the 2018 syllabus, despite the fact that since 1990, the weight attributed to that meaning in syllabi has gradually shrunk, to almost completely disappear in 2002. 
To answer a question: “why is the history of literature needed to be taught in schools?”, I started my analysis from pointing out the disappearing trust in historical and literary syntheses. This trust has been plummeting for over 40 years, which is connected to the so-called crisis of representation. In my view, the answer to my question may lie in the analysis of the 1949 syllabus document, in which the vision of the past is construed with a very apparent ideological intention, despite efforts to keep up the pretense of objectivity. By exposing the mechanisms that lead the authors of the 1949 document, I try to show to what extent the domination of chronological order opens up the potential of school documents to manipulate the past, which can lead to falsifying the images of cultural tradition.
Uczynić tradycję bliższą uczniowskim doświadczeniom… – refleksje o współczesnym czytaniu poezji w szkole ponadpodstawowej
Authors: Karkut Dorota
Published: December 2021

The subject of the articleis to discuss the problem of reading poetry in the changing educational reality. As research material, I used the statements made by students on how to work with poetica Texas Turing Polish language lessons in secondary school as well as testimonies of the reception of the works of Jan Kochanowski and Ignacy Krasicki, taking into account the experiences of contemporary teenagers, collected in questionnaires.
Strajk klimatyczny młodych jako motywacja dla lektury… tomiku Milczenie roślin Wisławy Szymborskiej i rozmowy o wierszach
Authors: Jaskółowa Ewa
Published: December 2021

The author asks the question, how young people’s interest in ecology can be combined with reading poetry by Wisława Szymborska. The article proposes that conversations about contemporary climate threats, should be made an introduction to the lesson in reading poems from the collection: The Silence of Plants. It shows how the emotional involvement of young people in the contemporary problems of planet protection, can be used to interest in poetic reflection on nature. Conversation about poems leads to the presentation of poetry as a medium for expressing the views and emotions of young people.
Jak słucha ósmoklasista? Próba diagnozy
Authors: Chyb-Winnicka Marta
Published: December 2021

The aim of this article is an attempt to give an answer the question: What is the level of listening skills of the students who come to post-primary school? The author presents the results of research that she carried out using authorial listening comprehension texts. The research involved a group of 162 eighth grade students from four primary schools in Opole. The data obtained from this research show that eighth-graders demonstrate an average level of listening skills, there fore schools should take preventive measures aimed at in creasing the effectiveness of auditory perception.
Amasya İlinde Toprak Tarımı Çiftçilerinin Organik Tarım Anlayışı
Authors: Aksoy Mehmet , Karademir Başaran , Kadirhanoğulları İbrahim Hakkı
Published: December 2021

Organic Agricultural products are natural food products that are checked and certified by authorized institutions at all stages of cultivation and presented to the consumer. In this study, the knowledge and practices of soil agriculture farmers in Amasya province about Organic Agriculture production were investigated by face-to-face survey method. In the survey, the local producers were asked what Organic Agriculture is in general, their status of producing Organic Agriculture, whether they fulfill the Organic Agriculture requirements for Organic Agriculture production. The obtained data were presented numerically and proportionally. Data were also analyzed with the Decision Tree method using the CART (Classification and Regression Tree) algorithm. According to the findings, although the local farmers declared that they knew what Organic Agriculture was at a high level, it was seen that none of the producers fulfilled the requirements of Organic Agriculture in practice. According to the survey data, while the farmers reported that they received the information about Organic Agriculture from TV-radio and the internet to a large extent (58.5%), a very small percentage (11%) stated that they received training. According to this result, it has been concluded that the local farmers do not have enough information about Organic Agriculture, but the lack of information can be easily eliminated via TV-radio and the internet. As a result, it was concluded that Amasya farmers do not have sufficient information about Organic Agriculture production for now, but if appropriate training is provided, successful Organic Agriculture production output can be achieved.
Evaluation of Some Ecute Phase Proteins, Cytokines and Hepcidin Levels in Naturally Infected Saanen Goats with Paratuberculosis
Authors: SEVGİSUNAR Necmettin Sarp , ŞAHİNDURAN Şima
Published: December 2021

Johne’s Disease or paratuberculosis is a mycobacterial infection of ruminants and has a global economical impact. Mycobacterium avium subsp. paratuberculosis is the cause of this disease. It reduces milk production, cause chronic weight loss leading death and major losses. Acute phase reactions are defined as minimum 25% increase or decrease in serum concentrations of acute phase proteins which are triggered by pro or antiinflammatory cytokines released from various cells or tissues. The aim of the study was to investigate the effect of Mycobacterium avium subsp paratuberculosis on blood parameters, some acute phase proteins, cytokines and hepcidin in naturally infected goats with paratuberculosis. In this study, total 45 Saanen goats aged 2-5 years from both sex were used as animal material. Study group were included 35 and control group were included 10 animal for evaluation. Complete blood counts were performed on blood taken from all animals. Also interleukin 6, interleukin 10, serum amyloid A, haptoglobin, fibrinogen, and hepcidin levels were evaluated from serum samples. As a result, interleukin 6 (p
Revisión de la experiencia regulatoria en Colombia sobre las fintech y el desarrollo del sandbox regulatorio
Authors: Pertuz Yustes Diana
Published: December 2021

Es innegable que con el desarrollo tecnológico de la última década, el mundo se ha transformado de forma más acelerada. Lo es igualmente, que dicho desarrollo ha generado la creación de nuevos modelos de negocio en la industria financiera, que han cambiado de forma radical la oferta y la demanda de sus productos y servicios. Es así como las fintech se presentan como una gran oportunidad de evolución en el sector financiero tradicional, a nivel local e internacional. Éste artículo pretende realizar una descripción de los desarrollos regulatorios en Colombia frente a la aparición de las fintech; y, responder a la pregunta, de si dichos desarrollos, en conjunto con el sandbox regulatorio, como mecanismo de mitigación de riesgos, son suficientes para promover de forma efectiva la innovación y modernización del sistema financiero, para una prestación más eficiente de servicios, que facilite igualmente, la inclusión financiera en Colombia.
Sistema de saneameno doméstico: eficácia do uso de fossa verde para o tratamento unifamiliar de esgoto
Authors: Cunha da Silva Soralene , Sarpedonti Valerie
Published: December 2021

A universalização dos serviços de saneamento no Brasil torna-se um desafio para os administradores públicos, sobretudo em municípios de pequeno porte, devido à pouca disponibilidade de recursos financeiros. No município de Tomé-açu/PA, a maioria da população rural, em 2010, destinava seu esgoto sanitário de forma inadequada, como uso de fossas negras ou a céu aberto. Diante deste cenário, foi aplicado um questionário em uma comunidade rural deste município, visando caracterizar a situação do saneamento. Os resultados serviram de base para a viabilidade e implantação de um sistema fossa verde para tratar esgoto sanitário doméstico em duas residências. Os resultados demonstraram que os domicílios não possuem sistema de distribuição e tratamento de água. Toda água utilizada pelos moradores é proveniente de poços ou nascentes. Não existe coleta pública ou particular dos resíduos sólidos gerados, a alternativa utilizada é a queima. As condições de lançamento de efluentes são precárias, pois não possuem sistema de captação e tratamento de efluentes. O esgoto doméstico gerado nas pias e lavanderias é disposto a céu aberto. A fossa negra ainda é utilizada pela grande maioria dos munícipes. Tais condições, aliadas à ausência de ações de educação ambiental na comunidade, afetam a saúde principalmente das crianças. A implementação da fossa verde trouxe uma nova perspectiva para as famílias beneficiadas, pois é um sistema de baixo custo, fácil operação e manutenção e pode substituir o uso de fossas rudimentares. As análises das frutas oriundas das fossas estão dentro dos padrões estabelecidos pela legislação.
GESTÃO DE CUSTOS NAS MICRO E PEQUENAS INDÚSTRIAS DO SETOR DE CONFECÇÕES DE UMUARAMA E REGIÃO
Authors: Campos Gervaldo Rodrigues
Published: December 2021

RESUMO: Este trabalho, desenvolvido junto às micro e pequenas indústrias do setor de confecções de Umuarama e região, teve como objetivo identificar as práticas de gestão de custos utilizadas por elas. Para tanto, estudou-se a prática na gestão de custos industriais das empresas objeto da presente pesquisa, por aplicação de questionário estruturado com questões fechadas, encaminhado por e-mail. Com base nos resultados alcançados, pode-se afirmar que a maioria absoluta das empresas participantes da pesquisa utiliza planilha ou software específico para determinar e controlar os custos envolvidos na sua atividade, pois, das 16 empresas, 15 delas (93,75% por cento) responderam afirmativamente. Por outro lado, quanto à principal decisão tomada com base nas informações produzidas pelo sistema de custos utilizado pela empresa, 9 afirmaram que decidem a formação do preço de venda dos seus produtos; 2 afirmaram decidir sobre a margem de lucro dos seus produtos, 1 afirmou decidir a margem de contribuição dos seus produtos, 2 afirmaram decidir sobre compra ou produção dos seus produtos e 2 afirmaram tomar outras decisões. Conclui-se por este trabalho que a maioria das indústrias do setor de confecções e Umuarama e região possui sistemas de custos claramente estruturados, porém a pesquisa também revelou a necessidade de melhoria na eficiência dos controles dos seus custos de produção, sobretudo no tocante à utilização de conceitos e técnicas de maior eficiência no contexto do apoio ao processo decisório, além de sistemas integrados de gestão, fatores indispensáveis para a eficiência na gestão das organizações neste ambiente altamente competitivo em que as empresas se encontram inseridas.
The Binding Nature of the Ombudsman’s Remedial Actions in Lesotho: Lessons from South Africa
Authors: 'Nyane Hoolo
Published: December 2021

The Constitution of Lesotho is regarded as liberal, with the separation of powers of the executive, judiciary and legislature, but provision was made for institutions to oversee the exercise of such powers. One of these is the Office of the Ombudsman, which has wide-ranging powers to investigate malpractice in public administration and to make recommendations for remedial action. These powers notwithstanding, there is a paucity of judicial precedent and scholarship on the binding nature of the remedial action of the Ombudsman. The main question is whether the remedial action of the Ombudsman is binding, which this article seeks to investigate and determine whether South African jurisprudence could be helpful in the case of Lesotho. The binding nature of the Public Protector’s remedial action under the Constitution of South Africa has been a subject of considerable judicial and scholarly engagement in recent times. While the subject is still yet to be settled in South Africa, it nevertheless has developed principles that could assist in both the interpretation and reform of the Ombudsman’s powers in Lesotho.
Extraterritorial Use of Force against Non-State Actors: PS to Hague Academy Lectures
Authors: Tladi Dire
Published: December 2021

In July 2021, the author presented a Special Course for the Hague Academy of International Law Summer Courses on the Extraterritorial Use of Force against Non-State Actors. The course focused on two bases for the extraterritorial use of force against non-state actors, namely self-defence and intervention by invitation. The lectures came to a conclusion that may, at first glance, appear contradictory. With respect to the use of force in self-defence, the lectures adopted a restrictive (non-permissive) approach in which the use of force is not permitted save in narrowly construed exceptions. With respect to intervention by invitation, the lectures adopted a more permissive approach in which the use of force is generally permitted and prohibited only in narrowly construed exceptions. This article serves as post-script (PS), to explain the apparent contradiction. It concludes that the main reason for this apparent contradiction is the application of the fundamental principles of international law—sovereignty, territorial integrity and independence—which are consistent with intervention by invitation but are undermined by self-defence against non-state actors.
Educação em saúde realizada por enfermeiros para mulheres com neoplasia de mama: revisão integrativa
Authors: Monteiro Amanda Suélen , Dallabrida Giovana Sangiogo , Machado Anahy da Silva , Scopel Mariana Ferreira , Bugs Cíntia Vanuza Monteiro , Dias Elise de Fátima Rodrigues , Lemos Sabrina Madrid , Regis Denise de Oliveira Hasselman , Cogo Silvana Bastos , Sehnem Graciela Dutra
Published: December 2021

Objetivo: Avaliar as evidências científicas relacionadas às práticas de educação em saúde desenvolvidas por enfermeiros na assistência à saúde para mulheres com neoplasia de mama. Métodos: Revisão integrativa da literatura, com levantamento bibliográfico realizado via bases de dados do Portal Regional da Biblioteca Virtual em Saúde, portal Pubmed e base de dados SciVerse Scopus. Incluíram-se estudos originais em português, inglês ou espanhol, sem recorte temporal, justificado pela intenção de identificar a produção de conhecimento ao longo do tempo acerca dessa temática. Resultados: O corpus foi composto por 17 artigos e a análise dos dados possibilitou agrupá-los em três categorias temáticas: Utilização de tecnologias educacionais como fonte de informações, Educação em saúde para rastreamento e diagnóstico precoce: o que auxilia e o que dificulta?, E Enfermeiro como educador em saúde: auxiliando mulheres que convivem com neoplasia de mama. Considerações finais: As tecnologias educativas são importantes estratégias para viabilizar o fornecimento de informações em saúde, fazendo com que as mulheres que vivem com neoplasia de mama consigam compreender o seu processo de saúde-doença. Ainda, o enfermeiro é visualizado como uma figura referência no desenvolvimento de educação em saúde, de modo a contribuir para o desenvolvimento de estratégias de enfretamento e de autocuidado.
Application of video surveillance equipment for fire detection
Authors:   Academy of State Fire Service of EMERCOM of Russia, Chlenov A. N. , Kochegarov A. V. ,   Academy of State Fire Service of EMERCOM of Russia, Butcinskaya T. A. ,   Academy of State Fire Service of EMERCOM of Russia, Aleshkov A. M. ,   Academy of State Fire Service of EMERCOM of Russia
Published: December 2021

Introduction. The fire safety of the protected object is determined by the possibility of reliable fire detection. Insufficiently effective operation of the fire alarm system can lead to the death of people, unacceptable material and other damage. The video surveillance system, being one of the main links of the engineering security system, monitors emergency situations in real time and, in particular, a breakout of fire at the protected object. Goals and objectives. The purpose of the article is to analyze the state and trends in the development of video surveillance equipment aimed at improving the fire safety of protected objects. Tasks include regulatory justification of the use of video surveillance in fire alarm systems, review of methods of fire detection by video surveillance and improving their effectiveness under the influence of interfering factors, as well as evaluation of the effectiveness of video surveillance in fire protection systems. Methods. The methods of the system analysis and probability theory are used. Results and discussion. The requirements of regulatory documents for detectors with a video detection channel for their effective operation in fire alarm systems are considered. The main directions of development of means and methods of application of video surveillance in fire protection systems are defined. It is shown that reducing the risk of non-detection of fire to an acceptable level can be achieved by increasing the probability of effective operation of the fire alarm system, as well as by increasing the positive impact of the video surveillance system, which is a part of the complex security system of the object. Conclusions. Video surveillance significantly increases the efficiency of fire detection. It allows you to get a visual picture of the state of the protected object, which has such a high information content that no other security means can provide. The use of video surveillance equipment in fire alarm systems, as well as their integration with industrial and fire automation systems is one of the main reserves for increasing the fire safety of facilities. Keywords: video surveillance, fire detector with video detection channel, fire alarm, video analytics, fire protection
Research of acoustic discomfort and pollution environment by increased flow motor transportation in the south district of Belgorod
Authors:   Belgorod State Technological University named after V. G. Shukhov, Edamenko A. S. , Yastrebinskaya A. V. ,   Belgorod State Technological University named after V. G. Shukhov, Semeykin A. Yu. ,   Belgorod State Technological University named after V. G. Shukhov
Published: December 2021

Introduction. The present time is characterized by the rapid development of cities and, as a consequence, the aggravation of a whole set of problems. Cities provide a fairly high standard of living for the population, satisfy their needs, but at the same time, they are the center of the significant environmental problems. All this is due to the excessive concentration of transport and economic facilities in relatively small areas. Goals and objectives. The aim of the work is to assess the level of impact of vehicles in terms of noise pollution and air pollution in Belgorod Construction of noise maps of individual microdistricts of Belgorod and calculation of emissions of the main pollutants into the air from traffic flows, which will make it possible to predict and identify areas of the urban environment where the established sanitary and hygienic standards are exceeded. Methodology. The study of the noise situation in certain areas of the city was carried out in accordance with the requirements of GOST 20444-2014 and GOST 53187-2008. The main characteristic was the equivalent sound level of traffic flows, calculated from the results of instrumental measurements of the noise level. To assess air pollution, calculations were carried out according to the methodology for calculating emissions of pollutants into the atmosphere by vehicles on city highways. Field observations to study traffic flows were carried out in the daytime. Results and its discussion. The obtained data on the noise level on the territory of the studied microdistrict were used to compile a noise map, which makes it possible to identify areas of the urban environment that do not meet sanitary and hygienic requirements for the noise factor. Calculation data for emissions of harmful substances from vehicles can be used to create environmental passports and are useful in making decisions to reduce the negative impact of transport on the environmental situation of industrial cities. Conclusion. The study of noise pollution and atmospheric air pollution, the source of which is motor vehicles, in an urban environment, makes it possible to develop a complex of health-improving, environmental, urban planning measures and a number of architectural and planning solutions aimed at reducing the level of noise pollution and air pollution in these areas. Keywords: urbanized areas, vehicles, noise pollution, emissions of harmful substances
Efficacy of screening cancer patients at hospital entrance for COVID-19 with a questionnaire and thermal scanning: An audit
Authors: Mishra Gauravi A. , Goel Nishu S. , Gupta Sudeep , Laskar Sarbani , Tiloda Apoorva V. , Bhagwat Ankita A. , Kulkarni Vasundhara Y. , Shaikh Heena Kauser A. , Pramesh C. S. , Tandon Sandeep P. , Sawakare Sandeep S. , Sengar Manju , Biswas Sanjay K. , Epari Sridhar , Shetty Omshree A. , Desai Sangeeta B. , Badwe Rajendra A.
Published: December 2021

Objectives:

Although commonly practiced, the accuracy, effectiveness, and safety of screening patients for COVID-19 at hospital entrances is not well documented.

Material and Methods:

We performed a retrospective analysis of single institution data involving screening patients for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection at hospital entrances by trained health personnel, with thermal scanning and administration of a standard questionnaire eliciting risk factors and symptoms of COVID-19. SARS-CoV-2 positivity among patients screened positive and negative and among personnel involved in screening were estimated.

Results:

Between May 22, 2020, and July 4, 2020, a total of 20152 patients involving 54955 hospital visits were screened at hospital entrances of whom 668 (3.31%, 95% CI 3.07–3.57) were screened positive for suspected COVID-19 and 19484 (96.69%, 95% CI 96.44–96.93) were screened negative. Among patients screened positive, of the 638 patients with available records, 109 (17.08%, 95% CI 14.24–20.23) were confirmed to be SARS-CoV-2 positive by polymerase chain reaction test, 288 (45.14%, 95% CI 41.23–49.10) were negative, 71 (11.13%, 95% CI 8.79–13.83) were not tested after secondary assessment, and 170 (26.65%, 95% CI 23.25–30.26) patients declined the test. Among screen negative patients, 162 (0.83%, 95% CI 0.71–0.97) were SARS-CoV-2 positive. Of the 104 personnel involved in screening, 03 (2.88%, 95% CI 0.60–8.20) were confirmed to be SARS-CoV-2 positive during study period.

Conclusion:

Screening patients with a combination of thermal scanning and a standard questionnaire for COVID-19 has a high positive predictive value for detecting this infection with low risk of SARS-COV-2 transmission to the involved health personnel.
FAKTOR-FAKTOR YANG BERHUBUNGAN DENGAN PERILAKU IBU DALAM PENCEGAHAN HIV DI DESA BALAI JAYA KELURAHAN BALAI JAYA ROKAN HILIR
Authors: Irwan Muhammad Irwan Siregar , Maharani Riri , Syukaisih Syukaisih
Published: December 2021

This journal about HIV
PENGARUH KOMPRES AIR HANGAT TERHADAP PENURUNAN NYERI HAID (DISMINOREA) PADA SISWI SMK NEGERI 1 RAMBAH SAMO KABUPATEN ROKAN HULU TAHUN 2020
Authors: Ayu Lestari Winda , Priwahyuni Yuyun , Gloria Purba Christine Vita
Published: December 2021

ABSTRACT

Painful menstruation (disminorea) is a medical condition that occurs when menstrual characterized by pain or pain in the region of the abdomen and pelvis. Painful menstruation had an impact that bad , which is causing a disturbance in teaching and learning activities , and did not go to school. According to World Health Organization (who) years 2016 the world disminorea rata-rata more than 50% women have it. SMK N 1 Rambah Samo Is one of vocational high schools are a lot of the number of teenagers his daughter who suffered painful menstruation, but the school has not yet there were scouts health especially about how to overcome painful menstruation ( disminorea ) and have not yet pik formation of a teenager ( information center and a teenager ) counseling in order to to give information and counseling services to students. Painful menstruation (disminorea) could be non therapy farmokologi, one compress warm water. Compress warm water is a method to give the heat and causes dilation of the blood vessels so that painful menstruation that was felt to be reduced. Research objectives was to find the influence of compress warm water to a decrease in painful menstruation (disminorea) in female students of SMK N 1 Rambah Samo in 2020. This study used Quasi Ekspeimen design Nonequivalent Control Group. With population as 60 sample of 34 , consisting of 17 the control group and 17 the experiment. Sampel taken by purposive sampling technique. The Analysis used Wilcoxon test. The result showed that any impact to compress warm water a decline in painful menstruation in the experiment with the ? value (0,0001) <0,05 while in the control group did not show a decline in the painful menstruation ? value (1,000) >0,05. It is expected that compress warm water used for an alternative to reduce the feeling of hurt when mestruasi.

 

Keywords               : Painful menstruation, compress warm water, Students
ANALISIS KELENGKAPAN STANDAR INSTALASI LABORATORIUM DI RSIA ERIA BUNDA PEKANBARU TAHUN
Authors: Nurning Utami Triana , Abidin Aldiga Rienarti , Candra Leon
Published: December 2021

Laboratorium klinik adalah laboratorium kesehatan yang melaksanakan pelayanan, pemeriksaan specimen klinik untuk mendapatkan informasi tentang kesehatan perorangan terutama untuk menunjang upaya diagnosis penyakit, penyembuhan penyakit, dan pemulihan kesehatan.Tujuan penelitian ini secara umum untuk mengetahui Analisi Kelengkapan Standar Instalasi Laboratorium di RSIA Eria Bunda Pekanbaru Tahun 2020.Dilakukan wawancara mendalam dan observasi kepada 5 informan.Lokasi penelitian dilakukan di RSIA Eria Bunda Pekanbaru di jln.K.H.Ahmad Dahlan No.163 Sukajadi Pekanbaru, Riau, khususnya dibagian laboratorium pada bulan Maret-April 2020.Hasil penelitian menunjukkan bahwa SDM di laboratorium belum sesuai dengan standar, Sarana di laboratorium belum sesuai dengan standar, Prasarana di laboratorium belum sesuai dengan standar, dan SOP di laboratorium belum sesuai dengan standarnya. Dari hasil penelitian dapat disimpulkan bahwa SDM di laboratorium masih perlu penambahan SDM atau memaksimalkan SDM yang ada dengan menggatur ulang jadwal shiff, Sarana di laboratorium harus dilengkapi dari ruang-ruangan sampai alat laboratorium, Prasarana menyediakan KM/WC untuk pasien dan petugas secara terpisah disekitar laboratorium, dan SOP di laboratorium perlu adanya pengawasan untuk staf analis dalam menerapkan SOP di RSIA Eria Bunda Pekanbaru Tahun 2020.
A clinical laboratory is a health laboratory that provides service, examines clinical specimen to obtain information on individual health, especially to support effort to diagnose disease, cures disease and restores health. The purpose of this study generally was to determine the analysis of standard completeness of laboratory installation at RSIA Eria Bunda Pekanbaru in 2020. In-depth interview and observation were conducted with 5 informants. The location of the research was carried out at RSIA Eria Bunda Pekanbaru on KH. Ahmad Dahlan street No.163 Sukajadi Pekanbaru, Riau, especially in the laboratory section on March-April 2020. The result showed that the human resources in the laboratory were not in accordance with standard, the facility in the laboratory was not in accordance with the standard, the infrastructure in the laboratory was not in accordance with the standard, and SOP in the laboratory was not in accordance with the standard. From the result of the study it can be concluded that the human resources in the laboratory still need to add more human resources or maximize existing human resources by resetting the shiff schedule, the facility in the laboratory must be equipped from rooms to laboratory equipment, infrastructure provides bathroom /toilet for patient and staff separately around the laboratory , and SOP in the laboratory needs supervision for analizing staff in implementing SOP at RSIA Eria Bunda Pekanbaru in 2020.
Report on validation of the stochastic traffic simulation (Part B)
Authors:   Chair of Automobile Engineering, Bäumler Maximilian , Ringhand Madlen ,   Chair of Traffic and Transportation Psychology, Siebke Christian ,   Chair of Automobile Engineering, Mai Marcus ,   Chair of Automobile Engineering, Elrod Felix , Prokop Günther ,   Chair of Automobile Engineering
Published: December 2021

This document is intended to give an overview of the validation of the human subject study, conducted in the driving simulator of the Chair of Traffic and Transportation Psychology (Verkehrspsychologie – VPSY) of the Technische Universität Dresden (TUD), as well of the validation of the stochastic traffic simulation developed in the AutoDrive project by the Chair of Automotive Engineering (Lehrstuhl Kraftfahrzeugtechnik – LKT) of TUD. Furthermore, the evaluation process of a C-AEB (Cooperative-Automatic Emergency Brake) system is demonstrated. The main purpose was to compare the driving behaviour of the study participants and the driving behaviour of the agents in the traffic simulation with real world data. Based on relevant literature, a validation concept was designed and real world data was collected using drones and stationary cameras. By means of qualitative and quantitative analysis it could be shown, that the driving simulator study shows realistic driving behaviour in terms of mean speed. Moreover, the stochastic traffic simulation already reflects reality in terms of mean and maximum speed of the agents. Finally, the performed evaluation proofed the suitability of the developed stochastic simulation for the assessment process. Furthermore, it could be shown, that a C-AEB system improves the traffic safety for the chosen test-scenarios.
Report on integration of the stochastic traffic simulation
Authors:   Chair of Automobile Engineering, Siebke Christian , Bäumler Maximilian ,   Chair of Automobile Engineering, Ringhand Madlen ,   Chair of Traffic and Transportation Psychology, Mai Marcus ,   Chair of Automobile Engineering, Elrod Felix , Prokop Günther ,   Chair of Automobile Engineering
Published: December 2021

As part of the AutoDrive project, the OpenPASS framework is used to develop a cognitive-stochastic traffic flow simulation for urban intersection scenarios described in deliverable D1.14. This framework was adapted and further developed. The deliverable D5.13 deals with the construction of the stochastic traffic simulation. At this point of the process, the theoretical design aspects of D4.20 are implemented. D5.13 explains the operating principles of the different modules. This includes the foundations, boundary conditions, and mathematical theory of the traffic simulation.
Optimizing the use of a “Zero-Gap” Gas Diffusion Electrode Setup for Electrochemical Reduction of CO2
Authors: Alinejad Shima , Quinson Jonathan , Li Yao , Kong Ying , Reichenberger Sven , Barcikowski Stephan , Broekmann Peter , Arenz Matthias
Published: December 2021

The lack of a robust and standardized experimental test bed to investigate the performance of catalyst materials for the electrochemical CO2 reduction reaction (ECO2RR) is one of the major challenges in this field of research. To best reproduce and mimic commercially relevant conditions for catalyst screening and testing, gas diffusion electrode (GDE) setups attract a rising attention as an alternative to conventional aqueous-based setups such as the H-cell configuration. In particular a zero-gap design shows promising features for upscaling to the commercial scale. In this study, we develop further our recently introduced zero-gap GDE setup for the CO2RR using an Au electrocatalyst as model system and identify/report the key experimental parameters to control in the catalyst layer preparation in order to optimize the activity and selectivity of the catalyst.
Enhancing the Inhomogeneonus Photodynamics of Canonical Bacteriophytochrome
Authors: Rydzewski Jakub , Walczewska-Szewc Katarzyna , Czach Sylwia , Nowak Wiesław , Kuczera Krzysztof
Published: December 2021

The ability of phytochromes to act as photoswitches in plants and microorganisms depends on interactions between a bilin-like chromophore and a protein. The interconversion occurs between the spectrally distinct red (Pr) and far-red (Pfr) conformers. This conformational change is triggered by the photoisomerization of the chromophore D-ring pyrrole. In this study, as a representative example of a phytochrome-bilin system, we take biliverdin IXα (BV) bound to bacteriophytochrome (BphP) from Deinococcus radiodurans. In the absence of light, we use an enhanced sampling molecular dynamics (MD) method to overcome the photoisomerization energy barrier. We find that the calculated free energy (FE) barriers between essential metastable states agree with spectroscopic results. We show that the enhanced dynamics of the BV chromophore in BphP triggers nanometer-scale conformational movements that propagate by two experimentally determined signal transduction pathways. Most importantly, we describe how the metastable states enable a thermal transition known as the dark reversion between Pfr and Pr, through a previously unknown intermediate state of Pfr. Here, for the first time, the heterogeneity of temperature-dependent Pfr states is presented at the atomistic level. This work paves a way toward understanding the complete mechanism of the photoisomerization of a bilin-like chromophore in phytochromes.
Development of a First-in-Class Small Molecule Inhibitor of the C-terminal Hsp90 Dimerization
Authors: Bhatia Sanil , Spanier Lukas , Bickel David , Dienstbier Niklas , Woloschin Vitalij , Vogt Melina , Pols Henrik , Lungerich Beate , Reiners Jens , Aghaallaei Narges , Diedrich Daniela , Frieg Benedikt , Schliehe-Diecks Julian , Boop Bertan , Lang Franziska , Gopalswamy Mohanraj , Loschwitz Jennifer , Bajohgli Baubak , Skokowa Julia , Borkhardt Arndt , Hauer Julia , K. Hansen Finn , H.J. Smits Sander , Jose Joachim , Gohlke Holger , Kurz Thomas
Published: December 2021

Heat shock protein 90 (Hsp90) is a promising therapeutic target due to its involvement in stabilizing several aberrantly expressed oncoproteins. In cancerous cells, Hsp90 expression is elevated, thereby contributing in exerting anti-apoptotic effects, which is essential for the malignant transformation and progression of several tumor types. Most of the Hsp90 inhibitors (Hsp90i) under investigation target the ATP binding site in the N-terminal domain (NTD) of Hsp90. However, adverse effects, including induction of the pro-survival resistance mechanism (heat shock response or HSR) and associated dose-limiting toxicity, have so far precluded clinical approval of these Hsp90i. In contrast, modulators that interfere with the C-terminal domain (CTD) of Hsp90 do not inflict HSR and, thus, emerge as a promising alternative approach to target Hsp90. Since the CTD dimerization of Hsp90 is essential for its chaperone activity, interfering with this essential dimerization process by small-molecule protein-protein interaction (PPI) inhibitors is a promising strategy for anticancer drug research. We have developed the first-in-class small molecule inhibitor (5b) targeting the Hsp90 CTD dimerization interface, based on a tripyrimidonamide scaffold through structure-based molecular design, chemical synthesis, binding mode model prediction, assessment of the biochemical affinity and efficacy against therapy-resistant leukemia cells. 5b reduces xenotransplantation of leukemia cells in zebrafish models and induces apoptosis in BCR-ABL1+ (T315I) tyrosine kinase inhibitors (TKIs) resistant leukemia cells, without inducing HSR.
Más allá del bien y del mal: los superhéroes de la Marvel y la DC
Authors: León Frías Isaac
Published: December 2021

En el horizonte del cine fantástico contemporáneo, las aventuras a cargo de los personajes nacidos en las páginas de las historietas de las compañías Marvel y DC desempeñan un papel central. A ellos y a las películas que les sirven de vehículo de lucimiento está dedicado este artículo, a través de un amplio recorrido histórico.
Testimonio de un Sith y miembro de Gryffindor limeño
Authors: Mera Arnaldo
Published: December 2021

Mucho más que una serie de películas, con universos propios que no dejan de crecer y actualizarse, las cintas de La guerra de las galaxias y Harry Potter son auténticos acontecimientos que se enmarcan en distintas etapas de la vida de sus seguidores. Coincidan o no con sus estrenos, las experiencias son distintas y cómo se llega a ellas también. Son sagas que unen a distintas generaciones de aficionados y crean un lenguaje común entre ellos, tal como lo demuestra este testimonio.
Cinco entradas al terror norteamericano contemporáneo
Authors: Bedoya Forno Rodrigo
Published: December 2021

En los últimos años, las películas de terror de los Estados Unidos de Norteamérica y Canadá han conseguido impactar a los espectadores, al explorar nuestros miedos más profundos a través de leyendas urbanas, mutaciones del cuerpo, criaturas que funcionan como metáforas del miedo al compromiso o que se conectan a recursos propios de la comedia. Los cinco filmes que se comentan son un buen punto de partida para explorar un género que sigue siendo atractivo en la actualidad.