bluuebunny/crossref_metadata_2025 huggingface dataset:
Multi-omics intervention in Setaria to dissect climate-resilient traits: Progress and prospects
Authors: Aggarwal Pooja Rani , Pramitha Lydia , Choudhary Pooja , Singh Roshan Kumar , Shukla Pooja , Prasad Manoj , Muthamilarasan Mehanathan
Published: August 2022

Millets constitute a significant proportion of underutilized grasses and are well known for their climate resilience as well as excellent nutritional profiles. Among millets, foxtail millet (Setaria italica) and its wild relative green foxtail (S. viridis) are collectively regarded as models for studying broad-spectrum traits, including abiotic stress tolerance, C4 photosynthesis, biofuel, and nutritional traits. Since the genome sequence release, the crop has seen an exponential increase in omics studies to dissect agronomic, nutritional, biofuel, and climate-resilience traits. These studies have provided first-hand information on the structure, organization, evolution, and expression of several genes; however, knowledge of the precise roles of such genes and their products remains elusive. Several open-access databases have also been instituted to enable advanced scientific research on these important crops. In this context, the current review enumerates the contemporary trend of research on understanding the climate resilience and other essential traits in Setaria, the knowledge gap, and how the information could be translated for the crop improvement of related millets, biofuel crops, and cereals. Also, the review provides a roadmap for studying other underutilized crop species using Setaria as a model.
Addressing the contribution of small molecule-based biostimulants to the biofortification of maize in a water restriction scenario
Authors: Hernandiz Alba E. , Jiménez-Arias David , Morales-Sierra Sarai , Borges Andres A. , De Diego Nuria
Published: August 2022

Biostimulants have become an asset for agriculture since they are a greener alternative to traditionally used plant protection products. Also, they have gained the farmers’ acceptance due to their effect on enhancing the plant’s natural defense system against abiotic stresses. Besides commercially available complex products, small molecule-based biostimulants are useful for industry and research. Among them, polyamines (PAs) are well-studied natural compounds that can elicit numerous positive responses in drought-stressed plants. However, the studies are merely focused on the vegetative development of the plant. Therefore, we aimed to evaluate how drenching with putrescine (Put) and spermidine (Spd) modified the maize production and the yield quality parameters. First, a dosage optimization was performed, and then the best PA concentrations were applied by drenching the maize plants grown under well-watered (WW) conditions or water deficit (WD). Different mechanisms of action were observed for Put and Spd regarding maize production, including when both PAs similarly improved the water balance of the plants. The application of Put enhanced the quality and quantity of the yield under WW and Spd under WD. Regarding the nutritional quality of the grains, both PAs increased the carbohydrates content, whereas the contribution to the protein content changed by the interaction between compound and growth conditions. The mineral content of the grains was also greatly affected by the water condition and the PA application, with the most relevant results observed when Spd was applied, ending with flour richer in Zn, Cu, and Ca minerals that are considered important for human health. We showed that the exogenous PA application could be a highly efficient biofortification approach. Our findings open a new exciting use to be studied deep in the biostimulant research.
Verification of sap flow characteristics and measurement errors of Populus tomentosa Carr. and Salix babylonica L. based on the liquid level equilibrium method
Authors: Liu Yunjie , Zhang Hanhan , Ma Changming , Liu Bingxiang , Ding Changjun
Published: August 2022

This study clarified the characteristics and influencing factors of sap flow in Populus tomentosa Carr. and Salix babylonica L., and verified the applicability of Granier’s original formula for measuring the sap flow of the two species, aimed to provide a basis for the accurate assessment of tree transpiration. P. tomentosa and S. babylonica were used as research objects, their sap flow was measured by the thermal dissipation probe method (TDP), together with changes in meteorological factors and soil water content. Meanwhile, the transpiration of both species was measured by the liquid level equilibrium method (LLE) to verify the applicability of Granier’s original formula. We found that: (1) the sap flow velocity of P. tomentosa and S. babylonica under typical sunny and cloudy conditions showed unimodal or bimodal changes, which were highly significantly correlated with meteorological factors (P < 0.01), but they were all small and poorly correlated with meteorological factors on rainy days. (2) The sap flow velocity of both species was significantly and negatively correlated (P < 0.05) with the daily change in stem and soil water content at 10–20 cm. (3) Compared to that calculated with the LLE method, the sap flows of the two species calculated by the TDP technique using Granier’s original formula were seriously underestimated, with error rates of -60.96% and -63.37%, respectively. The Granier’s correction formulas for P. tomentosa and S. babylonica established by the LLE method were Fd = 0.0287K1.236 (R2 = 0.941) and Fd = 0.0145K0.852 (R2 = 0.904), respectively, and the combined correction formula was Fd = 0.0235K1.080 (R2 = 0.957). It was verified that the errors of sap flow calculated by the specific correction formulas for P. tomentosa and S. babylonica were -6.18% and -5.86%, and those calculated by the combined correction formula were -12.76% and -2.32%, respectively. Therefore, the characteristics of the sap flow velocity of P. tomentosa and S. babylonica on sunny, cloudy and rainy days were different and significantly influenced by meteorological factors. The original Granier’s formula for calculating their sap flow resulted in a large error, but can be measured more accurately by constructing specific correction and combination formulas through the LLE method.
Diet of the earliest modern humans in East Asia
Authors: Wu Yan , Tao Dawei , Wu Xiujie , Liu Wu , Cai Yanjun
Published: August 2022

Reconstructing diet can offer an improved understanding toward the origin and evolution of modern humans. However, the diet of early modern humans in East Asia is poorly understood. Starch analysis of dental calculus is harmless to precious fossil hominins and provides the most direct evidence of plant food sources in early modern human dietary records. In this paper, we examined the starch grains in dental calculus from Fuyan Cave hominins in Daoxian (South China), which were the earliest modern humans in East Asia. Our results reveal the earliest direct evidence of a hominin diet made of acorns, roots, tubers, grass seeds, and other yet-unidentified plants in marine isotope stage 5 between 120 and 80 ka. Our study also provides the earliest evidence that acorns may have played an important role in subsistence strategies. There may have been a long-lasting tradition of using these plants during the Late Pleistocene in China. Plant foods would have been a plentiful source of carbohydrates that greatly increased energy availability to human tissues with high glucose demands. Our study provides the earliest direct consumption of carbohydrates-rich plant resources from modern humans in China for the first time. In addition, it also helps elucidate the evolutionary advantages of early modern humans in the late Middle and early Upper Pleistocene.
Root exudates and rhizosphere soil bacterial relationships of Nitraria tangutorum are linked to k-strategists bacterial community under salt stress
Authors: Pan Yaqing , Kang Peng , Tan Min , Hu Jinpeng , Zhang Yaqi , Zhang Jinlin , Song Naiping , Li Xinrong
Published: August 2022

When plants are subjected to various biotic and abiotic stresses, the root system responds actively by secreting different types and amounts of bioactive compounds, while affects the structure of rhizosphere soil bacterial community. Therefore, understanding plant–soil-microbial interactions, especially the strength of microbial interactions, mediated by root exudates is essential. A short-term experiment was conducted under drought and salt stress to investigate the interaction between root exudates and Nitraria tangutorum rhizosphere bacterial communities. We found that drought and salt stress increased rhizosphere soil pH (9.32 and 20.6%) and electrical conductivity (1.38 and 11 times), respectively, while decreased organic matter (27.48 and 31.38%), total carbon (34.55 and 29.95%), and total phosphorus (20 and 28.57%) content of N. tangutorum rhizosphere soil. Organic acids, growth hormones, and sugars were the main differential metabolites of N. tangutorum under drought and salt stress. Salt stress further changed the N. tangutorum rhizosphere soil bacterial community structure, markedly decreasing the relative abundance of Bacteroidota as r-strategist while increasing that of Alphaproteobacteria as k-strategists. The co-occurrence network analysis showed that drought and salt stress reduced the connectivity and complexity of the rhizosphere bacterial network. Soil physicochemical properties and root exudates in combination with salt stress affect bacterial strategies and interactions. Our study revealed the mechanism of plant–soil-microbial interactions under the influence of root exudates and provided new insights into the responses of bacterial communities to stressful environments.
Why are political discussions with fascists impossible? Reflections on the far-right politics of silence
Authors: Suuronen Ville
Published: August 2022

This paper argues that twentieth-century fascist political theory is characterised by the systematic attempt to abolish communication from the public realm. By offering a novel reading of one the most systematic fascist thinkers, Carl Schmitt, who is compared with Søren Kierkegaard, Aristotle, Hannah Arendt, and Walter Benjamin as well as with the Italian dictator Benito Mussolini, it is argued that Schmitt's Weimar era thought offers a many-sided challenge to the Western tradition of political thought. Against the Aristotelian notion of politics as rhetorical persuasion and speech, Schmitt mobilises the anti-Aristotelian political theorist, Thomas Hobbes, and an array of other thinkers for his own purposes in order to redefine “the political” as a realm of silence. For Schmitt, and for fascists more generally, the realm of the political appears as an arena in which absolute and non-negotiable existential truths collide—truths, which every political community must necessarily embody in both its constitution and spirit. Reinterpreting Schmitt's central works by relying on a broad array of rare materials, I maintain that Schmitt's famous criterion of the “the political” discloses the crucial moment in which communicative speech becomes impossible. It is argued that understanding the internal mechanics of twentieth century fascist political thought can be highly useful for grasping the momentum that especially far-right movements are experiencing today.
Bibliometric analysis of research themes and trends in childhood autism spectrum disorders from 2012 to 2021
Authors: Zhao Junqiang , Lu Yi , Wu Xingyang , Zhou Fujun , Fei Fangqin , Wu Xiaoyan , Ding Xiufang , Wang Minli
Published: August 2022

Background

Autism spectrum disorders (ASD) are heterogeneous neurodevelopmental conditions that affect people worldwide. Early diagnosis and clinical support help achieve good outcomes. However, medical system structure and restricted resource availability create challenges that increase the risk of poor outcomes. Understanding the research progress of childhood ASD in recent years, based on clinical literature reports, can give relevant researchers and rehabilitation therapists more resonable research guides.

Objective

This bibliometric study aimed to summarize themes and trends in research on childhood ASD and to suggest directions for future enquiry.

Methods

Citations were downloaded from the Web of Science Core Collection database on childhood ASD published from 1 January 2012, to 31 December 2021. The retrieved information was analyzed using CiteSpace.5.8. R3, and VOS viewer.

Results

A total of 7,611 papers were published across 103 areas. The United States was the leading source of publications. The clusters that have continued into 2020 include coronavirus disease 2019, gut microbiota, and physical activity, which represent key research topics. Keywords with frequency spikes during 2018–2021 were “disabilities monitoring network,” “United States,” and “caregiver.”

Conclusions

The Autism and Developmental Disabilities Monitoring Network in the United States can be used as a reference for relevant workers worldwide. An intelligent medical assistant system is being developed. Further studies are required to elucidate challenges associated with caring for a child with ASD.
Non-disclosed men who have sex with men within local MSM HIV-1 genetic transmission networks in Guangyuan, China
Authors: Zhuoma Lacuo , Zhang Yan , Yan Tu , Kang Fayang , Hou Xueqin , Chen Jianguo , Huang Min , Zeng Yali , Wang Qiushi , Zhou Chang , Liang Shu , Su Ling
Published: August 2022

Background

Most men who have sex with men (MSM), especially those with HIV infection, do not disclose their same-sex behaviors in China due to Chinese family values and fear of stigmatization, rejection, or prejudice. However, disclosure of same-sex behaviors to healthcare providers (HCPs) can be beneficial for reducing viral transmission and promoting their physical and mental health. In this study, by combining phylogenetic analysis with traditional epidemiological approaches, we tried to identify the MSM who do not disclose to HCPs in transmission networks and explored the factors related to the non-disclosed behaviors.

Method

Phylogenetic analysis was conducted using HIV pol sequences obtained from the drug-resistant surveillance program, which was collected as part of routine clinical care since 2012. Sequences were linked to the demographic data collected in the Chinese HIV/AIDS Comprehensive Response Information Management System (CRIMS). First, male patients in whom genetic sequences were within the molecular transmission clusters involving self-reported MSM were identified as potential MSM (pMSM). Then, a cross-sectional survey was conducted to supplement behavioral information and attitudes toward MSM.

Results

Our sample consisted of 190 pMSM patients. In total, 43.16% of the patients were likely to conceal same-sex behaviors during the first-self-report, and 14.73% of patients might continue to conceal a history of same-sex behaviors even after receiving medical care. The pMSM who concealed their same-sex behaviors were reluctant to accept medical services such as Voluntary Counseling and Testing (VCT) and had a lower likelihood of condom use. In addition, the related factors for non-disclosed behavior were associated with current address, income before diagnosis, and attitudes toward MSM.

Conclusion

Non-disclosure of same-sex behaviors to HCPs may be a major obstacle for certain medical services for MSM who exhibit risky sexual behaviors. The pMSM from developing areas, with high monthly income, and with neutral or un-supportive attitudes toward MSM may represent non-disclosure of their same-sex behaviors. Thus, policies facilitating MSM to disclose their same-sex behaviors are recommended, such as legislations protecting homosexual rights on employment, education, marriage, and so on.
Transient partial regression of intracranial germ cell tumor in adult thalamus: A case report
Authors: Luo Si-ping , Zhang Han-wen , Lei Yi , Feng Yu-ning , Yu Juan , Lin Fan
Published: August 2022

Background

Intracranial germ cell tumors (GCTs) are a relatively rare malignancy in clinical practice. Natural regression of this tumor is also uncommon. We describe a rare case of an intracranial GCT in the thalamus of an adult that showed spontaneous regression and recurrence after steroid therapy.

Case description

A 38-year-old male patient's MRI of the head suggested space-occupying masses in the left thalamus and midbrain. MRI examination revealed demyelination or granulomatous lesions. After high dose steroid treatment, the symptoms improved. The lesions were significantly reduced on repeat MRI, and oral steroid therapy was continued after discharge. The patient's symptoms deteriorated 1 month prior to a re-examination with head MRI, which revealed that the mass within the intracranial space was larger than on the previous image. He revisited the Department of Neurosurgery of our hospital and underwent left thalamic/pontine mass resection on October 16, 2019, and the pathological results showed that the tumor was a GCT.

Conclusion

Intracranial GCTs are rare in the adult thalamus but should be considered in the differential diagnosis. The intracranial GCT regression seen in this case may be a short-lived phenomenon arising from complex immune responses caused by the intervention.
Chronic blue light leads to accelerated aging in Drosophila by impairing energy metabolism and neurotransmitter levels
Authors: Yang Jun , Song Yujuan , Law Alexander D. , Rogan Conner J. , Shimoda Kelsey , Djukovic Danijel , Anderson Jeffrey C. , Kretzschmar Doris , Hendrix David A. , Giebultowicz Jadwiga M.
Published: August 2022

Blue light (BL) is becoming increasingly prevalent in artificial illumination, raising concerns about its potential health hazard to humans. In fact, there is evidence suggesting that acute BL exposure may lead to oxidative stress and death of retinal cells specialized for photoreception. On the other hand, recent studies in Drosophila melanogaster demonstrated that chronic BL exposure across lifespan leads to accelerated aging manifested in reduced lifespan and brain neurodegeneration even in flies with genetically ablated eyes, suggesting that BL can damage cells and tissues not specialized for light perception. At the physiological level, BL exposure impairs mitochondria function in flies, but the metabolic underpinnings of these effects have not been studied. Here, we investigated effects of chronic BL on metabolic pathways in heads of eyes absent (eya2) mutant flies in order to focus on extra-retinal tissues. We compared metabolomic profiles in flies kept for 10 or 14 days in constant BL or constant darkness, using LC-MS and GC-MS. Data analysis revealed significant alterations in the levels of several metabolites suggesting that critical cellular pathways are impacted in BL-exposed flies. In particular, dramatic metabolic rearrangements are observed in heads of flies kept in BL for 14 days, including highly elevated levels of succinate but reduced levels of pyruvate and citrate, suggesting impairments in energy production. These flies also show onset of neurodegeneration and our analysis detected significantly reduced levels of several neurotransmitters including glutamate and Gamma-aminobutyric acid (GABA), suggesting that BL disrupts brain homeostasis. Taken together, these data provide novel insights into the mechanisms by which BL interferes with vital metabolic pathways that are conserved between fly and human cells.
A novel technique for detecting sudden concept drift in healthcare data using multi-linear artificial intelligence techniques
Authors: M. S. Abdul Razak , Nirmala C. R. , Aljohani Maha , Sreenivasa B. R.
Published: August 2022

A financial market is a platform to produce data streams continuously and around 1. 145 Trillion MB of data per day. Estimation and the analysis of unknown or dynamic behaviors of these systems is one the challenging tasks. Analysis of these systems is very much essential to strengthen the environmental parameters to stabilize society activities. This can elevate the living style of society to the next level. In this connection, the proposed paper is trying to accommodate the financial data stream using the sliding window approach and random forest algorithm to provide a solution to handle concept drift in the financial market to stabilize the behavior of the system through drift estimation. The proposed approach provides promising results in terms of accuracy in detecting concept drift over the state of existing drift detection methods like one class drifts detection (OCDD), Adaptive Windowing ADWIN), and the Page-Hinckley test.
Biomass valorization by thermal treatments: Graphene-based materials and their application on glyphosate adsorption
Authors: Hernández-Barreto Diego Felipe , Bernal Valentina , Giraldo Liliana , Moreno-Piraján Juan Carlos , Rodriguez-Estupiñán Paola
Published: August 2022

Carbon-based nanomaterials have exceptional physicochemical properties like high surface area and active sites, suitable for the adsorption of inorganic and organic compounds. Currently, these materials are being tested for environmental applications, e.g., detecting emerging pollutants in drinking and surface water. This work reviews different methods to prepare graphene (G) or graphene-based materials (GBM) using biomass or its constituents. This text brings together the methods used to revalue biomass by converting it into graphene materials from thermal treatments and their application in the adsorption of glyphosate from an aqueous solution. Computational studies were also added to evaluate the information about interactions between the herbicide and graphene layers.
Evaluation of global techno-socio-economic policies for the FEW nexus with an optimal control based approach
Authors: Nisal Apoorva , Diwekar Urmila , Hanumante Neeraj , Shastri Yogendra , Cabezas Heriberto , Rico Ramirez Vicente , Rodríguez-González Pablo Tenoch
Published: August 2022

Inordinate consumption of natural resources by humans over the past century and unsustainable growth practices have necessitated a need for enforcing global policies to sustain the ecosystem and prevent irreversible changes. This study utilizes the Generalized Global Sustainability model (GGSM), which focuses on sustainability for the Food-Energy-Water (FEW) Nexus. GGSM is a 15-compartment model with components for the food-web, microeconomic framework, energy, industry and water sectors, and humans. GGSM shows that an increased per capita consumption scenario is unsustainable. In this study, an optimal-control theory based approach is devised to address the unsustainable scenario through policy interventions to evaluate sustainability by employing multiple global indicators and controlling them. Six policy options are employed as control variables to provide global policy recommendations to develop the multi-variate optimal control approach. Seven objectives are proposed to limit the human burden on the environment to ascertain sustainability from a lens of ecological, economic, and social wellbeing. This study observes the performance of the policy options toward seven sustainability indicators: Fisher Information, Green Net Product, Ecological Buffer, Carbon dioxide emissions, Nitrous oxide emissions, and Global Water Stress. The optimal control model assesses these multiple objectives by minimizing the variance in the Fisher Information. One significant result from this study is that optimizing for the Fisher Information based objective is adequate to attain sustainability and manage the other objectives under consideration. Thus, forgoing a multi-objective problem framework. The results show that cross-dimensional policy interventions such as increased vegetarianism and increased penalty on industrial discharge are shown to have a positive impact on scale.
Long-term osseointegration of laser-ablated hearing implants in sheep cranial bone
Authors: Johansson Martin Lars , Shah Furqan A. , Eeg-Olofsson Måns , Monksfield Peter , Thomsen Peter , Palmquist Anders
Published: August 2022

Osseointegration, the ability for an implant to be anchored in bone tissue with direct bone-implant contact and allowing for continuous adaptive remodelling, is clinically used in different reconstructive fields, such as dentistry, orthopedics and otology. The latter uses a bone conducting sound processor connected to a skin-penetrating abutment that is mounted on a titanium implant placed in the temporal bone, thereby acting as a path for transmission of the vibrations generated by the sound processor. The success of the treatment relies on bone healing and osseointegration, which could be improved by surface modifications. The aim of this study was to evaluate the long-term osseointegration in a sheep skull model and compare a laser-ablated implant surface with a machined implant. Commercially available 4 mm titanium implants, either with a machined (Wide Ponto) or a laser-ablated surface (Ponto BHX, Oticon Medical, Sweden), were used in the current study. The surfaces were evaluated by scanning electron microscopy. The implantation was performed with a full soft tissue flap and the osteotomy was prepared using the MIPS drill kit (Oticon Medical, Sweden) prior to installation of the implants in the frontal bone of eight female sheep. After five months, biopsies including the implant and surrounding bone tissue obtained, processed and analysed using histology, histomorphometry, scanning electron microscopy and Raman spectroscopy. The animals healed well, without signs of adverse events. Histomorphometry showed a large amount of bone tissue around both implant types, with 75% of the threaded area occupied by bone for both implant types. A large amount of bone-implant contact was observed for both implant types, with 67%–71% of the surface covered by bone. Both implant types were surrounded by mature remodelled lamellar bone with high mineral content, corroborating the histological observations. The current results show that the laser-ablated surface induces healing similar to the well-known clinically used machined surface in ovine cranial bone. In conclusion, the present long-term experimental results indicate that a laser-ablated implant performs equally well as a clinically used implant with a machined surface. This, together with previously reported, improved early biomechanical anchorage, suggests future, safe and efficient clinical potential.
Symptom duration is associated with failure of periprosthetic joint infection treated with debridement, antibiotics and implant retention
Authors: Shao Hongyi , Li Rui , Deng Wang , Yu Baozhan , Yang Dejin , Zhou Yixin , Chen Jiying
Published: August 2022

Background

Debridement, antibiotics, and implant retention (DAIR) is an alternative treatment strategy for periprosthetic joint infection (PJI). However, no consensus exists regarding which patient population(s) may be most suitable for DAIR. This study aims to investigate the overall infection control rate and explore the prognostic factors associated with acute, hematogenous, and chronic PJIs treated with DAIR.

Methods

We retrospectively reviewed the included patients who were diagnosed with PJI and underwent DAIR at two institutions from 2009 to 2018 (n = 104). We collected the clinical data, including demographics, preoperative laboratory tests, Charlson Comorbidity Index, surgical information, and culture organism results. Treatment success was defined according to the criteria reported by Diaz-Ledezma. All patients were followed for at least one year unless failure preceded that time point. A multivariable analysis was utilized to identify prognostic factors associated with treatment, and a Kaplan-Meier survival analysis was used to depict the infection control rate.

Results

The overall treatment success rate in the current cohort of patients was 67.3% at a median 38.6 (interquartile range: 23.5, 90.7) months follow-up. Patients with a duration of infectious symptoms of more than ten days were more likely to fail (P = 0.035, hazard ratio 8.492, 95% confidence interval 1.159–62.212). There was no difference among acute, hematogenous, and chronic infections in terms of failure rate (P = 0.161).

Conclusions

DAIR is a reasonable treatment option for PJI, and its use in the setting of chronic infection does not appear to be a contraindication. Performing DAIR within ten days of the presentation of symptoms had a higher rate of treatment success.
Laparo-endoscopic management of chole-choledocholithiasis: Rendezvous or intraoperative ERCP? A single tertiary care center experience
Authors: Lagouvardou Elpiniki , Martines Gennaro , Tomasicchio Giovanni , Laforgia Rita , Pezzolla Angela , Caputi Iambrenghi Onofrio
Published: August 2022

Introduction

The management of chole-choledocholithiasis remains a matter of debate to preserve minimal invasive management and different options have been proposed, with single- or two-stage approaches. Two techniques of single-stage approach are intraoperative ERCP and laparoscopic rendezvous, which have the great advantage of reducing the length of hospital stay with increased patient compliance. This retrospective study aims to evaluate and compare the efficacy and safety of intraoperative ERCP and rendezvous technique for more than 15 years.

Materials and methods

Clinical records of 113 patients who underwent single-stage management for chole-choledocholithiasis between January 2003 and December 2020 were retrospectively reviewed using a prospectively maintained database. Patients were separated into two groups: those managed with intraoperative ERCP and those with rendezvous, and their intraoperative and postoperative parameters were compared. All patients were followed up for 6 months in an outpatient setting.

Results

A total of 68 (60%) patients were treated with intraoperative ERCP, while the remaining 45 (40%) were treated with rendezvous. There were no significant differences in terms of comorbidities. ERCP was performed with a median operative time of 145 min (104–168) and an endoscopic time of 27 min (15–36). Meanwhile, rendezvous was performed with a significantly lower operative [120 min (94–147)] and endoscopic time [15 min (12–22)]. No intraoperative complications were recorded. Patients treated with rendezvous had a significantly shorter median hospitality stay [4 (3–5) vs. 3 (2–4) days, p < 0.05]. No hospital readmissions or mortalities were observed in either group after 30 days. Ten mild pancreatitis cases were observed, mainly in the intraoperative ERCP group (9 vs. 1, p < 0.05), and all were treated conservatively. Only two patients treated with intraoperative ERCP developed biliary complications later on.

Conclusion

Laparoscopic rendezvous should be considered a preferable alternative to intraoperative ERCP for the treatment of patients with concomitant CBD stones and gallstones.
Association of serum reproductive hormones changes after neoadjuvant chemotherapy with hormone receptors expression alterations and survival outcomes in breast cancer
Authors: Lan Ailin , Jin Yudi , Wang Yu , Ding Nan , Wang Yihua , Dai Yuran , Jiang Linshan , Tang Zhenrong , Peng Yang , Liu Shengchun
Published: August 2022

Purpose

This study aimed to determine the effect of neoadjuvant chemotherapy (NAC) on circulating levels of reproductive hormones and evaluate the correlation of hormone changes after NAC with hormone receptors expression alterations and relapse-free survival (RFS) outcomes in breast cancer.

Methods

Information from 181 breast cancer patients who received NAC was retrospectively analyzed. For hormones parameters, the median and interquartile range (IQR) were provided at baseline and the end of NAC then was compared by Wilcoxon signed-rank test. Categorical variables were represented as numbers and percentages and were compared via two-sided chi-square and Fisher's tests. The RFS outcomes were compared between patients according to hormone changes using the log-rank test. Univariate and multivariate survival analyses with hazard ratios (HR) and 95% confidence intervals (95% CI) were carried out using Cox regression.

Results

Sex steroids including estradiol, progesterone, testosterone, and dehydroepiandrosterone sulfate (DHEAS) levels decreased significantly after NAC among both premenopausal and postmenopausal patients (all P < 0.05). Decreased estradiol levels were associated with reduced progesterone receptor (PR) expression (P = 0.030). In multivariate survival analysis, the non-decreased progesterone level was strongly associated with worse RFS (non-decreased vs. decreased, HR = 7.178, 95% CI 2.340–22.019, P = 0.001). Patients with decreased progesterone levels exhibited better 3-year RFS compared with those with non-decreased (87.6% vs. 58.3%, log-rank, P = 0.001).

Conclusion

Multiple reproductive hormone levels were influenced by NAC. The change in estradiol level had a positive connection with PR expression alteration. Furthermore, an inverse association between the change in progesterone level and RFS outcomes was found. These findings may provide a theoretical basis for pre-operative endocrine therapy combined with NAC in breast cancer patients.
Surgical management of tuberculum sellae meningioma: Transcranial approach or endoscopic endonasal approach?
Authors: Qian Kang , Nie Chuansheng , Zhu Wende , Zhao Hongyang , Zhang Fangcheng , Wang Haijun , Jiang Xiaobing
Published: August 2022

Background

Tuberculum sellae meningioma (TSM), a common benign tumor in the sellae region, usually causes neurological deficits, such as vision impairment, by squeezing the peripheral neurovascular structures. Surgical management is recommended as the optimal strategy for TSM treatment and vision restoration. However, it remains challenging to resect TSM in the traditional transcranial approach (TCA). Recently, the endoscopic endonasal approach (EEA) has emerged as an effective option in skull base surgeries. Besides the effectivity, the advantages and limitations of EEA in TSM surgery remain controversial.

Object

We compared the surgical outcomes and complications between TCA and EEA surgeries to identify the principles in TSM surgical management.

Methods

Retrospective analysis was performed on the patients, who underwent TSM surgery in Wuhan Union Hospital between January 2017 and December 2021. The patients were assigned to TCA or EEA group according to the surgery they experienced. All patients were analyzed with the extent of tumor resection, vision outcome, postoperative complications, and follow-up results.

Results

A total of 112 patients were enrolled in this study, including 78 in TCA group and 34 in EEA group. The mean follow-up was 20.5 months (range 3–36 months). There were no statistically significant differences in patient demographic data, preoperative symptoms, and tumor characteristics between TCA and EEA groups. Both TCA and EEA surgeries are effective in TSM resection with relatively high gross total resection rates (85.9% in TCA vs. 91.2% in EEA, p > .05). Meanwhile, EEA surgery has a better outcome in vision restoration or stabilization than TCA surgery (74.6% in TCA vs. 93.1% in EEA, p < .05). Whereas EEA surgery causes more occurrences of cerebrospinal fluid (CSF) leakage than TCA surgery (0% in TCA vs. 11.8% in EEA, p < .05).

Conclusion

Both TCA and EEA surgeries are effective in TSM resection. EEA surgery has a better outcome in vision restoration or stabilization than TCA surgery, but induces higher risk of CSF leakage. As each approach has unique advantages and limitations, we must take all aspects into consideration, including approach feathers, tumor characteristics, and clinical requirements, to make the optimal choice in TSM surgical management.
Images Segmentation Based on Cutting the Graph into Communities
Authors: Belim Sergey V. , Belim Svetlana Yu.
Published: August 2022

This article considers the problem of image segmentation based on its representation as an undirected weighted graph. Image segmentation is equivalent to partitioning a graph into communities. The image segment corresponds to each community. The growing area algorithm search communities on the graph. The average edge weight in the community is a measure of the separation quality. The correlation radius determines the number of next nearest neighbors connected by edges. Edge weight is a function of the difference between color and geometric coordinates of pixels. The exponential law calculates the weights of an edge in a graph. The computer experiment determines the parameters of the algorithm.
Lightweight Dual-Mode Soft Actuator Fabricated from Bellows and Foam Material
Authors: Jiao Zhiwei , Zhuang Zhongyu , Cheng Yue , Deng Xuan , Sun Ce , Yu Yuan , Li Fangjun
Published: August 2022

Foam-based soft actuators are lightweight and highly compressible, which make them an attractive option for soft robotics. A negative pressure drive would complement the advantages of foam actuators and improve the durability of the soft robotic system. In this study, a foam actuator was designed with a negative pressure pneumatic drive comprising bellows air chambers, a polyurethane foam body, and sealing layers at the head and tail. Experiments were performed to test the bending and contraction performances of the actuator with the foaming multiplier and air chamber length as variables. At air pressures of 0–90 kPa, the bending angle and contraction of the actuator increased with the foaming multiplier and number of air chamber sections. The designed actuator achieved a bending angle of 56.2° and contraction distance of 34 mm (47.9% of the total length) at 90 kPa, and the bending and contraction output forces were 3.5 and 7.2 N, respectively. A control system was built, and four soft robots were constructed with different numbers of actuators. In experiments, the robots successfully completed operations such as lifting, gripping, walking, and gesturing. The designed actuator is potentially applicable to debris capture, field rescue, and teaching in classrooms.
What Does Northern European Travel Means to South Koreans? Focusing on Travel Decision Process
Authors: Park Ji Hyon , Shin Hyung-Deok , Seo Young-Doc
Published: August 2022

The main purpose of this study is to analyze different types of information that may have diverse effects on the travel decision-making process. We collected the most frequently used words related to “Northern European travel” from Korean news sources and blogs, to determine whether there were any systematic differences through network text analysis and CONCOR analysis. We found that Koreans are exposed to words such as “nature” and “cruise activities”, which may lead them to perceive traveling in Northern Europe as a special experience. While political and diplomatic issues are frequently discussed in the news, practical information is discussed in blogs.
Do Takeover Threats Stifle or Promote Managerial Efforts to Innovate? Evidence from Takeover Vulnerability, and Text-Based Measure of Innovation
Authors: Denlertchaikul Nattarinee , Chatjuthamard Pattanaporn , Jiraporn Pornsit , Phiromswad Piyachart
Published: August 2022

Although the role of managers is crucial in shaping firm innovation, it also poses a dilemma. Because innovation is a complicated and long-term process that requires effort and attention, managers may reduce effort in innovation when faced with high takeover threat. This study examines the effects of hostile takeover threats on managerial efforts to innovate. Our results show that more active hostile takeover markets stifle managerial efforts in corporate innovation. The findings suggest that managers tend to be more myopic when firms are exposed to hostile takeover threats. Managers will put less effort into innovation to counter the risk of being dismissed as the expected payoff from such investment is long-term and highly uncertain. Additional robustness checks confirm the results, including random-effects regressions, an alternative measure of innovation, and two instrumental-variable analyses.
Efflux Pumps and Multidrug-Resistance in Pyricularia oryzae Triticum Lineage
Authors: Vicentini Samara Nunes Campos , Moreira Silvino Intra , da Silva Abimael Gomes , de Oliveira Tamiris Yoshie Kiyama , Silva Tatiane Carla , Assis Junior Fabio Gomes , Krug Loane Dantas , de Paiva Custódio Adriano Augusto , Leite Júnior Rui Pereira , Teodoro Paulo Eduardo , Fraaije Bart , Ceresini Paulo Cezar
Published: August 2022

Widespread resistance to QoIs, DMI and SDHIs fungicides has been reported for Brazilian populations of the wheat blast pathogen Pyricularia oryzae Triticum lineage (PoTl). A pre-existing resistance mechanism not associated with target site mutations has been indicated for resistance to DMIs and SDHIs, with strong indication that PoTl has multidrugresistance (MDR). Therefore, the main objective of this study was to test the hypothesis that resistance to DMI and SDHI fungicides detected in PoTl was due to efflux pump mediated MDR mechanism(s) by characterizing the sensitivity to antifungal efflux pump substrates. Four antifungal substrates were tested: tolnaftate (TOL), cycloheximide (CHX), rhodamine 6G (RH6G) and triphenyltin chloride (TPCL). TPCL and RH6G were considered the most relevant indicators for enhanced MDR activity. Among the 16 PoTl isolates tested, 9 were insensitive to TPCL, 1 to TOL, 16 to RH6G and 1 to CHX. The PoTl isolates were grouped into four distinct multidrug resistance phenotypes (MDRPs) based on resistance to combinations of fungicides and antifungal efflux pump substrates. Insensitivity to TPCL, RH6G and or TOL correlated well with DMI insensitivity, but MDR was not associated with SDHI resistance. The identification of multiple MDRP phenotypes associated with DMI resistance in our study warrants further research aimed at revealing the exact mechanisms of multidrug resistance in the wheat blast pathogen, including efflux pumps overexpression via transcriptomic analyses of differentially expressed genes; identification and discovery of mutations associated with changes in promoter regions or transcription factors of efflux transporters associated with multidrug resistance.
Mechanisms and Strategies of Plant Microbiome Interactions to Mitigate Abiotic Stresses
Authors: Munir Neelma , Hanif Maria , Abideen Zainul , Sohail Muhammed , El-Keblawy Ali , Radicetti Emanuele , Mancinelli Roberto , Haider Ghulam
Published: August 2022

Abiotic stresses are the most significant factors reducing agricultural productivity. Plants face extreme environmental conditions that may affect their biological mechanisms, thereby influencing their growth and development. Microorganisms possess substantial metabolites that aid in helping plants mitigate abiotic stresses. Plants’ interaction with microbes constitutes a diversified ecosystem, as sometimes both the partners share a mutualistic relationship. Endophytes, plant-growth-promoting rhizobacteria (PGPRs), and arbuscular mycorrhizal fungi (AMFs) are examples of microorganisms that play an essential role in alleviating abiotic stresses and, hence, improving plant growth. The plant–microbe interaction leads to the modulation of complex mechanisms in the plant cellular system. Moreover, the residing microbial flora also inhibits the phytopathogens, therefore, it becomes part of plants’ innate defense system. Keeping in view the growing environmental concerns, it is important to identify the role of the plant microbiome in the transportation of nutrients to maintain sustainable production. Furthermore, it is important to identify the factors enabling plants to recruit beneficial microbial species and how to deal with the potential pathogens. Therefore, this review aims to summarize the impacts of various abiotic stressors on agricultural productivity and the role of beneficial microorganisms in mitigating the negative effects of abiotic stresses. The literature review also shows that the beneficial microbes, including PGPRs, AMFs, and endophytes, adopt various mechanisms for ameliorating the negative effects of various stresses. It has been observed that biochar and microbes, either individually or in combination, can play a significant role in maintaining plant growth under stress conditions. Although conventional inoculation of beneficial microbes mitigates abiotic stresses and enhances productivity, the advancement in genetic engineering would help transfer specific genes from the microbes to plants to aid in abiotic stress mitigation.
Analysis of Long-Term Effect of Tillage Systems and Pre-Crop on Physicochemical Properties and Chemical Composition of Soil
Authors: Stankowski Sławomir , Jaroszewska Anna , Osińska Beata , Tomaszewicz Tomasz , Gibczyńska Marzena
Published: August 2022

The aim of the present study was to analyse the physicochemical properties and chemical composition of soil after years of applying varied tillage systems and pre-crops. The field experiments were carried out in Lipnik in Poland. The experiment was conducted over 25 years, with factor I–3 tillage systems: ploughing (A), ploughless (B) and direct sowing (C), factor II-pre-crop–1–faba bean, 2–sugar beet. Simplified tillage systems were used, and increased acidity was found in both layers due to lower pH, as well as an increase in exchangeable aluminum, hydrolytic acidity and exchangeable acidity of soil. The simplification of tillage system resulted in no significant effect on the following soil parameters: sum of base cations (TEB), cation exchange capacity (CEC) and electrical conductivity (EC). In both layers, there was a marked increase in the content of total nitrogen, carbon and available magnesium in soil with ploughless (B) and direct sowing (C) tillage systems. The change of the tillage system, which implied tillage reduction, was found to be the factor which has a significant effect on the physicochemical properties and chemical composition of soil. Tillage resulted a greater effect on the physicochemical properties, whereas pre-crop was found to affect the changes in chemical composition of soil to a greater extent. The results obtained in the research indicate that the tillage systems ploughless (B) and direct sowing (C) can be applied in practice.
Surface Defect Detection of “Yuluxiang” Pear Using Convolutional Neural Network with Class-Balance Loss
Authors: Sun Haixia , Zhang Shujuan , Ren Rui , Su Liyang
Published: August 2022

With increasing consumer expectations for the quality and safety of agricultural products, intelligent quality detection and gradation have considerable significance in agricultural production. The surface defect is an important indicator of quality, but is classified mainly using inefficient manual identification for “Yuluxiang” pears. Because of the uncertainty and high difficulty of image acquisition in agriculture, the data imbalance between categories is a common problem. For the resolution of these problems, the class balance (CB) was used to re-weight the sigmoid cross-entropy loss (SGM-CE), softmax cross-entropy loss (SM-CE), focal loss (FL) functions in this study. CB-SGM-CE, CB-SM-CE, and CB-FL were used to construct a GoogLeNet network as a convolutional neural network (CNN) generalized feature extractor, and transfer learning was combined to build detection models, respectively. The results showed that CB-SGM-CE, CB-SM-CE, and CB-FL were better than SGM-CE, SM-CE, and FL, respectively. CB-FL achieved the best detection results (F1 score of 0.993–1.000) in 3 CB loss functions. Then, CB-FL was used to construct VGG 16, AlexNet, SqueezeNet, and MobileNet V2 networks based on transfer learning, respectively. Machine learning (ML) and CNN were used to build classification models in this study. Compared with ML models and the other 4 CNN models, the CB-FL-GoogLeNet model achieved the best detection results (accuracy of 99.78%). A system for surface defect detection was developed. The results showed that the testing accuracy of the CB-FL-GoogLeNet model was 95.28% based on this system. This study realizes the surface defect detection of the “Yuluxiang” pear with an unbalanced dataset, and provides a method for intelligent detection in agriculture.