bluuebunny/crossref_metadata_2025 huggingface dataset:
Tauroursodeoxycholic acid: a bile acid that may be used for the prevention and treatment of Alzheimer’s disease
Authors: Song Honghu , Liu Jiancheng , Wang Linjie , Hu Xiaomin , Li Jiayu , Zhu Li , Pang Rizhao , Zhang Anren
Published: February 2024

Alzheimer’s disease (AD) is a prevalent neurodegenerative disease that has become one of the main factors affecting human health. It has serious impacts on individuals, families, and society. With the development of population aging, the incidence of AD will further increase worldwide. Emerging evidence suggests that many physiological metabolic processes, such as lipid metabolism, are implicated in the pathogenesis of AD. Bile acids, as the main undertakers of lipid metabolism, play an important role in the occurrence and development of Alzheimer’s disease. Tauroursodeoxycholic acid, an endogenous bile acid, has been proven to possess therapeutic effects in different neurodegenerative diseases, including Alzheimer’s disease. This review tries to find the relationship between bile acid metabolism and AD, as well as explore the therapeutic potential of bile acid taurocursodeoxycholic acid for this disease. The potential mechanisms of taurocursodeoxycholic acid may include reducing the deposition of Amyloid-β protein, regulating apoptotic pathways, preventing tau hyperphosphorylation and aggregation, protecting neuronal synapses, exhibiting anti-inflammatory properties, and improving metabolic disorders. The objective of this study is to shed light on the use of tauroursodeoxycholic acid preparations in the prevention and treatment of AD, with the aim of identifying effective treatment targets and clarifying various treatment mechanisms involved in this disease.
Subject-specific information enhances spatial accuracy of high-density diffuse optical tomography
Authors: Srinivasan Sruthi , Acharya Deepshikha , Butters Emilia , Collins-Jones Liam , Mancini Flavia , Bale Gemma
Published: February 2024

Functional near-infrared spectroscopy (fNIRS) is a widely used imaging method for mapping brain activation based on cerebral hemodynamics. The accurate quantification of cortical activation using fNIRS data is highly dependent on the ability to correctly localize the positions of light sources and photodetectors on the scalp surface. Variations in head size and shape across participants greatly impact the precise locations of these optodes and consequently, the regions of the cortical surface being reached. Such variations can therefore influence the conclusions drawn in NIRS studies that attempt to explore specific cortical regions. In order to preserve the spatial identity of each NIRS channel, subject-specific differences in NIRS array registration must be considered. Using high-density diffuse optical tomography (HD-DOT), we have demonstrated the inter-subject variability of the same HD-DOT array applied to ten participants recorded in the resting state. We have also compared three-dimensional image reconstruction results obtained using subject-specific positioning information to those obtained using generic optode locations. To mitigate the error introduced by using generic information for all participants, photogrammetry was used to identify specific optode locations per-participant. The present work demonstrates the large variation between subjects in terms of which cortical parcels are sampled by equivalent channels in the HD-DOT array. In particular, motor cortex recordings suffered from the largest optode localization errors, with a median localization error of 27.4 mm between generic and subject-specific optodes, leading to large differences in parcel sensitivity. These results illustrate the importance of collecting subject-specific optode locations for all wearable NIRS experiments, in order to perform accurate group-level analysis using cortical parcellation.
Optimization of conceptual design on the lead-based modular nuclear power reactor core loaded with U-10Zr alloy fuel
Authors: Lou Lei , Wang Lianjie , Peng Xingjie , Chen Zhang , Zhou Bingyan , Zhao Chen , Zhang Bin , Yan Mingyu , Ma Dangwei , Wang Xingbo , Zhao Zifan , Zhang Ce
Published: February 2024

As one of the forth-generation nuclear energy system reactor types, lead fast reactor has good safety and economical properties due to the stable chemical properties of the coolant and the proliferation characteristics of the fuel, and modular nuclear power faster reactor designed for nuclear plant can further improve the economics of the reactor. In this article, the conceptual design of the lead-based modular power reactors with different power levels loaded with uranium alloy fuel is found to be found that when reactor core size increased to a certain level, the proliferation performance is too high due to the increase of the reactor core size under a specific core life such as 2000EFPD, so at the end of core life, the reactor core still has a large remaining reactivity. The proliferation advantage of the core cannot be fully released during the current core life time. Based on this phenomenon, in this article, we optimized the conceptual design of lead-based modular nuclear power reactor core loaded with uranium alloy fuel, and proposed to choose the appropriate rod to diameter ratio and effective density of fuel based on the power level and life time of the core. By adjusting the amount of uranium and 235U per unit volume, the proliferation performance of the core can be changed to match the power level and life time of the core. So the reactivity of core during the life period does not change, which not only reduce the difficulty of the reactivity control, but also make full use of the proliferation performance of the core. And at the same time, the reasonable rod to diameter ratio can provide safety and design margin for the analysis of thermal and hydraulic safety, and effectively improve the economy and safety of the core.
Investigating the potential causal association between consumption of green tea and risk of lung cancer: a study utilizing Mendelian randomization
Authors: Lu Jieming , Lin Ye , Jiang Junfei , Gao Lei , Shen Zhimin , Yang Changping , Lin Pinghua , Kang Mingqiang
Published: February 2024

Background

Lung cancer is the most common global cancer in terms of incidence and mortality. Its main driver is tobacco smoking. The identification of modifiable risk factors isa public health priority. Green tea consumption has been examined in epidemiological studies, with inconsistent findings. Thus, we aimed to apply Mendelian randomization to clarify any causal link between green tea consumption and the risk of lung cancer.

Methods

We utilized a two-sample Mendelian randomization (MR) approach. Genetic variants served as instrumental variables. The goal was to explore a causal link between green tea consumption and different lung cancer types. Green tea consumption data was sourced from the UK Biobank dataset, and the genetic association data for various types of lung cancer were sourced from multiple databases. Our analysis included primary inverse-variance weighted (IVW) analyses and various sensitivity test.

Results

No significant associations were found between green tea intake and any lung cancer subtypes, including non-small cell lung cancer (adenocarcinoma and squamous cell carcinoma) and small cell lung cancer. These findings were consistent when applying multiple Mendelian randomization methods.

Conclusion

Green tea does not appear to offer protective benefits against lung cancer at a population level. However, lung cancer's complex etiology and green tea's potential health benefitssuggest more research is needed. Further studies should include diverse populations, improved exposure measurements and randomized controlled trials, are warranted.
How I approach: the transplant recipient with fever and pulmonary infiltrates
Authors: Kumar Madan , Hanisch Benjamin R.
Published: February 2024

Recipients of hematopoietic stem cell transplants and solid organ transplants frequently develop pulmonary infiltrates from both infectious and non-infectious etiologies. Differentiation and further characterization of microbiologic etiologies—viral, bacterial, and fungal—can be exceedingly challenging. Pediatric patients face unique challenges as confirmatory evaluations with bronchoscopy or lung biopsy may be limited. A generalizable approach to diagnosing and managing these conditions has not been well established. This paper aims to summarize our initial clinical approach while discussing the relative evidence informing our practices. A pediatric patient with characteristic infiltrates who has undergone HSCT is presented to facilitate the discussion. Generalizable approaches to similar patients are highlighted as appropriate while highlighting considerations based on clinical course and key risk factors.
Influence of cytochrome P450 2D6*10/*10 genotype on the risk for tramadol associated adverse effects: a retrospective cohort study
Authors: Mahajna Mahmood , Abu Fanne Rami , Odeh Mahmoud , Berkovitch Matitiahu , Tannous Elias , Eyal Sara , Vinker Shlomo , Green Ilan , Matok Ilan
Published: February 2024

Background: Tramadol is primarily metabolized by the highly polymorphic CYP2D6 enzyme, leading to a large spectrum of adverse events and clinical response. Ample evidence pointed a reduced CYPD26 activity score in individuals harboring the CYP2D6*10/*10 genotype, nevertheless, there is scarce studies on the impact of CYP2D6*10/*10 genetic polymorphism on long-term tramadol’s adverse effects.

Aim: To test the correlation between CYP2D6*10/*10 expression and the risk for tramadol-associated adverse effects.

Method: Using a database of Leumit Healthcare Services in Israel, we retrospectively assessed the occurrence of adverse events in patients who were prescribed tramadol. A binary logistic regression model was applied to model the relationship between CYP2D6*10/*10 genotype and the occurrence of adverse effects.

Results: Data from four hundred ninety-three patients were included in this study. Only 25 (5.1%) patients were heterozygous for the CYP2D6*10 variant, while 56 patients (11%) were tested positive to the CYP2D6*10/*10 genotype. Compared to carriers of other variants, patients with the CYP2D6*10/*10 variant exhibited a higher occurrence of adverse events (odds ratio [OR] = 6.14, 95% confidence interval 3.18–11.83); the odds ratio for central nervous system adverse events and gastrointestinal adverse events were 5.13 (95% CI 2.84–9.28), and 3.25 (95% CI 1.78–5.93), respectively.

Conclusion: Among the different CYP2D6 genotypes, CYP2D6*10/*10 genotype carries the higher risk of tramadol related adverse events. Appreciating the frequency of this specific allele it seems prudent to pharmacogenetically screen patients considered for long term tramadol treatment for better tolerability and efficacy outcomes.
Identification of candidate chemosensory genes in Bactrocera cucurbitae based on antennal transcriptome analysis
Authors: Wang Jing Jing , Ma Chao , Yue Yang , Yang Jingfang , Chen Li Xiang , Wang Yi Ting , Zhao Chen Chen , Gao Xuyuan , Chen Hong Song , Ma Wei Hua , Zhou Zhongshi
Published: February 2024

The melon fly, Bactrocera cucurbitae (Coquillett) (Tephritidae: Diptera), is an invasive pest that poses a significant threat to agriculture in Africa and other regions. Flies are known to use their olfactory systems to recognise environmental chemical cues. However, the molecular components of the chemosensory system of B. cucurbitae are poorly characterised. To address this knowledge gap, we have used next-generation sequencing to analyse the antenna transcriptomes of sexually immature B. cucurbitae adults. The results have identified 160 potential chemosensory genes, including 35 odourant-binding proteins (OBPs), one chemosensory protein (CSP), three sensory neuron membrane proteins (SNMPs), 70 odourant receptors (ORs), 30 ionotropic receptors (IRs), and 21 gustatory receptors (GRs). Quantitative real-time polymerase chain reaction quantitative polymerase chain reaction was used to validate the results by assessing the expression profiles of 25 ORs and 15 OBPs. Notably, high expression levels for BcucOBP5/9/10/18/21/23/26 were observed in both the female and male antennae. Furthermore, BcucOROrco/6/7/9/13/15/25/27/28/42/62 exhibited biased expression in the male antennae, whereas BcucOR55 showed biased expression in the female antennae. This comprehensive investigation provides valuable insights into insect olfaction at the molecular level and will, thus, help to facilitate the development of enhanced pest management strategies in the future.
Feeling safe together vs. longing for touch. Affective, multisensorial contact in inclusive intra-active virtual/physical dance during the COVID-19 pandemic
Authors: Oertel Noora Talvikki
Published: February 2024

This article explores how feelings of safety were experienced through inclusive virtual/physical dance in relation to experiences of touch during the COVID-19 pandemic in Finland. The following are the measures I took to achieve the aim of this study. First, I introduce the context through previous studies and an example from the ethnographic material I gained from the inclusive X-Dance festival organized in June 2021 in Finland. Second, I explore how inclusive virtual/physical dance might help us experience feelings of safety through multisensorial experiences of touch related to communality when responding to wellbeing challenges caused by isolation. Using Laura U. Mark's theory about haptic looking and Karen Barad's term intra-action, I discuss different possibilities to approach touch as a feeling sense, as affective multisensorial contact, and through relations between different materialities. Third, I contrast these ideas with sensations of longing for the physical touch that virtual/physical dancing evokes. These experiences of longing invite me to reflect on the ambivalence about feelings of safety related to intentions to restore experiences of touch and communality through digitality. I introduce two examples from my interviews with dancers during the pandemic to discuss these ambivalences. I reflect on these interviews through Magdalena Górska's theory about corpo-materiality and corpo-affectivity. I contribute to discussions on feelings of safety by showing that multi-sensorial experiences and anti-normative understandings of body and touch enabled by the non-verbal language of dance may help us to contribute toward more inclusiveness in society, allowing us to generate holistic experiences of safety, which is another critical aim for post-pandemic times.
Embodied planning in climbing: how pre-planning informs motor execution
Authors: Luis-del Campo Vicente , Morenas Martín Jesús , Musculus Lisa , Raab Markus
Published: February 2024

Introduction

The aim of the study is to address embodied planning in climbing. Embodied planning was conceptualized as the interaction between perceptual-cognitive pre-planning and motor execution.

Methods

In an experimental study, 18 climbers were asked to pre-plan a climbing route and to perform the route afterward. During pre-planning, the visual search pattern of climbers was captured using a portable eye tracker. After previewing, they were invited to climb the wall.

Results

Results revealed that holds looked at during pre-planning were used twice as much during route execution than those not looked at. The duration of fixations was longer for holds used than those not used during route execution. The experience of climbers (training years) correlated with visual strategies and climbing performance, such that experienced participants climbed faster and fixated at the holds not used for a shorter time.

Discussion

The visual behaviors of climbers were influenced by their past sensorimotor experiences during route previewing, impacting subsequent climbing performance.
Microsaccades reflect attention shifts: a mini review of 20 years of microsaccade research
Authors: Gu Quan , Zhang Qikai , Han Yueming , Li Pengfei , Gao Zaifeng , Shen Mowei
Published: February 2024

Microsaccades are small, involuntary eye movements that occur during fixation. Since the 1950s, researchers have conducted extensive research on the role of microsaccades in visual information processing, and found that they also play an important role in human advanced visual cognitive activities. Research over the past 20 years further suggested that there is a close relationship between microsaccades and visual attention, yet lacking a timely review. The current article aims to provide a state-of-the-art review and bring microsaccades studies into the sight of attention research. We firstly introduce basic characteristics about microsaccades, then summarized the empirical evidence supporting the view that microsaccades can reflect both external (perception) and internal (working memory) attention shifts. We finally conclude and highlight three promising avenues for future research.
Individual and community-level factors associated with khat (Catha edulis) use among women of reproductive age in Halaba zone, South Ethiopia: a multilevel mixed effect analysis
Authors: Wogayehu Biruk , Demissie Tsegaye , Wolka Eskinder , Alemayehu Mekuriaw , Daka Kassa
Published: February 2024

Introduction

There is a paucity of data on factors associated with khat chewing among women of reproductive age using multilevel analysis. Furthermore, the effects of some potential factors like stressful life events, knowledge about and attitude toward the effects of khat have been given little attention and are not well understood. Therefore, this study aimed to examine the prevalence and multilevel factors associated with khat use among women of reproductive age in Halaba zone, South Ethiopia.

Methods

A community-based cross sectional study was conducted in Halaba zone from February to July, 2023. Systematic random sampling technique was used to include 1573 study participants. The dependent variable was current khat use, which is operationalized as using khat within 30 days preceding the study. An interviewer administered questionnaire was used for the data collection.

Results

The prevalence of current khat use among women of reproductive age was 65.9% [95%CI (63.5-68.2%)]. Factors significantly associated with khat use were; ages of women 35 and above years [Adjusted Odds Ratio (AOR) = 6.35, 95% CI: (3.62, 11.13)], ever married [AOR = 2.41, 95% CI: (1.10, 5.31)], secondary and above education [AOR = 0.28, 95% CI: (0.15, 0.49)], belong to richer household [AOR = 1.75, 95% CI: (1.12, 2.75)], mass media use [AOR = 3.12, 95% CI: (1.85, 4.81)], low knowledge about khat effects [AOR = 3.12, 95% CI: (1.85, 5.24)], positive attitude towards khat use [AOR = 11.55, 95% CI: (6.76, 19.71)], and strong social support [AOR = 0.43, 95% CI: (0.28, 0.64)] and non-user friend [AOR = 0.31, 95% CI: (0.20, 0.48)]. From the community level variables: rural residence [AOR = 5.06, 95% CI: (1.82, 14.09)] was significantly associated with khat use.

Conclusion

Khat use among women of reproductive age was found to be very high. From individual-level factors: advanced ages of women, secondary and above education, live in the richer wealth quintile, mass media exposure, low knowledge on khat effects, positive attitude towards khat use, strong social support, and from community-level variables: residing in rural area were significantly associated with khat use. Khat use screening for all women of childbearing age, as well as referral to substance use disorder centers for those women identified as having khat use disorder, should become a standard of care in all health facilities.
Pricing strategy research in the dual-channel pharmaceutical supply chain considering service
Authors: Lu Qian , Liu Qing , Wang Yong , Guan Mingke , Zhou Zhigang , Wu Yajun , Zhang Jiamin
Published: February 2024

In the context of developing a new era, the pharmaceutical supply chain market has gradually transformed from a seller’s market to a buyer’s market. The closer the consumers are, the greater the market pricing power, so the pharmaceutical market power of manufacturers and retailers has also changed. This study considers the effect of service on the pricing strategy of the pharmaceutical platform supply chain. The study aimed to coordinate optimization, and the coordination strategy of the pharmaceutical platform supply chain of complementary products is discussed mainly by researching the price and service factors. Various situations are studied by hypothesis and model solving. This study uses Stackelberg game decision-making. Manufacturers are at the forefront of platform supply chain decisions. The research found that the price was lower under centralized decision-making than under decentralized decision-making. Coordination between price and service levels needs attention in the pharmaceutical platform supply chain of complementary products, and the service level should be controlled within a certain range. Only by improving the service level can enterprises maximize profits, providing a theoretical basis for pharmaceutical supply chain pricing strategy research. Supply chain members must strive to improve service levels to improve medical supply consumers’ (patients) psychological satisfaction level. Service levels do not fully mitigate channel conflict. Therefore, pharmaceutical complements have become a way to alleviate the conflicts in the pharmaceutical platform supply chain.
Nurse-led lifestyle counseling in Polish primary care: the effect of current health status and perceived barriers
Authors: Znyk Małgorzata , Kostrzewski Szymon , Kaleta Dorota
Published: February 2024

Introduction

Our study included counseling on diet and physical activity, smoking, e-cigarette use, and alcohol consumption. The aim was to examine the correlates of counseling provided by primary care nurses with the health status/health behaviors of nurses and the barriers in the advice provided.

Materials and methods

In 2022, we conducted a cross-sectional survey among 331 nurses employed in the primary care sector in Lodz. The questionnaire consisted of three sections: characteristics of the patient population receiving treatment and provided with healthy lifestyle counseling by nurses, barriers to the process of assessing, controlling, and guiding patients, and health status/health behaviors of nurses.

Results

Eighty percent of the nurses in our study provided advice on diet and physical activity to primary care patients. Over 70% of the survey participants performed minimal anti-smoking interventions forsmokers, 67.7% for alcohol drinkers, and 56.8% for e-cigarette users. The correlates of counseling in the field of diet and physical activity turned out to be the knowledge and skills, which enabled nurses to provide advice (OR = 2.57, p < 0.01). The correlates of the conducted minimal anti-smoking interventions in smoking patients were: subjective assessment of overweight and obesity in nurses, knowledge and skills in conducting counseling (OR = 1.92, p < 0.05), and measuring body weight, height and BMI (OR = 2.18, p < 0.01). Among the three most common barriers identified by the nurses in the process of assessing, monitoring, and guiding patients were the opinion that patients are not interested in improving their diet, physical activity, and weight loss (60.7%), lack of time (51.4%), as well as the belief that patients find it too difficult to change their current habits (54.1%).

Conclusion

The results of our survey indicate that nurses’ participation in healthy lifestyle counseling in adult patients is unsatisfactory. Interventions in primary care should be designed considering the specific obstacles nurses may face in leading healthy lifestyles. Further training of nursing staff is required to increase their knowledge on healthy lifestyles.
Out of sight: chronic kidney diseases among diabetic patients attending care and follow up. Findings from pastoralist health facilities of Southern Ethiopia
Authors: Israel Eskinder , Borko Ushula Deboch , Mota Kuma , Tesfaw Mihret , Feleke Tihun , Abraham Awoke , Akako Bereket , Samuel Beniyam , Aynalem Amdehiwot
Published: February 2024

Background

In Ethiopia, the prevalence of chronic kidney disease (CKD) among the adult population ranges to 19.1%. The disease's impact has increased in low-resource settings due to a lack of knowledge about the condition and its risk factors. Diabetes is one of the numerous causes of CKD. Despite this, little was known in Ethiopia, particularly in the study area. This study aimed to identify the determinants of CKD among diabetic patients enrolled in care and follow up at pastoralist health facility of Jinka General Hospital (JGH), Southern Ethiopia, 2023.

Methods

An institutional-based cross-sectional study design was conducted among 626 diabetic patients recruited through a systematic random sampling. Data was collected using a structured interviewer-administered questionnaire and entered into Epi data version 7.2 and then exported to the Statistical Package for Social Sciences (SPSS) version 25 for further analysis. Bivariate and multivariate logistic regression analyses were conducted to find eligible variables for the later analysis. Variables with p < 0.25 at bivariate logistic regression were selected for multivariate logistic regression analysis. The variables with p < 0.05 at the multivariate analysis were taken as statically significant in the final model.

Results

The prevalence of CKD was 2.7% (95% CI: 1.12–6.01%). Place of residence (AOR: 4.84; 95% CI: 1.51–15.40), presence of hypertension (AOR: 5.69; 95% CI: 1.58–20.51) and family history of CKD (AOR: 6.20; 95% CI: 1.40–15.49) were factors associated with CKD among diabetes patients.

Conclusion

The prevalence found in this study was low when compared with the local studies. Provision of health education to diabetic patients on preventative measures such as physical exercise is cost-effective approach. Factors associated with CKD among diabetics can be significantly mitigated by strengthening the existing NCDs prevention packages in the study area particularly and in Ethiopia generally.
Comparison of metabolic syndrome prevalence and characteristics using five different definitions in China: a population-based retrospective study
Authors: Ma Keli , Liu Haiyang , Guo Leilei , Li Jinlong , Lei Yunxiao , Li Xiaoping , Sun Lu , Yang Liu , Yuan Ting , Wang Congzhi , Zhang Dongmei , Li Jing , Liu Mingming , Hua Ying , Zhang Lin
Published: February 2024

Background

Metabolic syndrome (MetS) is on the rise in developing countries and is characterized by a series of indications of metabolic disturbance. However, the prevalence of MetS varies under different definitions. The study aimed to compare five definitions of MetS in the China adult population, to explore their prevalence, characteristics and agreement.

Methods

The data for the retrospective study came from the China Health and Retirement Longitudinal Study (CHARLS), consisting of 9,588 participants (≥45). MetS definitions from International Diabetes Federation (IDF) (2006), National Cholesterol Education Program Adult Treatment Panel III (ATPIII) (2005), National Cholesterol Education Program Adult Treatment Panel III (ATPIII) (2001), Chinese Diabetes society (CDS) (2004) and the World Health Organization (WHO) (1999). We used binary and multivariable logistic analysis to explore factors connected with MetS.

Results

The five definitions of MetS led to different prevalence of MetS:34.52% by IDF (2006), 38.63% by ATP (2005), 25.94% by ATP (2001), 26.31% by CDS (2004), 21.57% by WHO (1999). According to the definition of IDF (2006) (22.32% vs. 45.06%), ATPIII (2005) definition (27.99% vs. 47.82%), ATPIII (2001) definition (15.37% vs. 35.07%), CDS (2004) definition (19.96% vs. 31.80%), and WHO (1999) definition (17.44% vs. 25.14%), the prevalence of MetS in men was low but in women was high. The agreement between the five definitions for men was good except for the IDF (2006) definition and ATPIII (2001) definition (kappa = 0.51), with kappa values from 0.64 to 0.85. For women, the agreement between the five definitions was good ranging from 0.67 to 0.95, however, except for the definition of CDS (2004) and the definition of IDF (2006) (kappa = 0.44), the definition of WHO (1999) and the definition of IDF (2006) (kappa = 0.55), and the definition of WHO (1999) and the definition of ATPIII (2005) (kappa = 0.54). Binary logistic analysis indicated that although the impact and relevance varied by sex and definition, age, education, marital status, current residence, current smoking, alcohol using, taking activities and number of chronic diseases were factors connected to MetS.

Conclusion

the prevalence and characteristics of the five definitions of MetS are different in the Chinese population. Therefore, it is vital to use the same definition for a country to diagnose MetS. On the other side, a lower prevalence in men than in women and the consistency of five MetS definitions are good in men but relatively poor in women.
Neuroimaging data repositories and AI-driven healthcare—Global aspirations vs. ethical considerations in machine learning models of neurological disease
Authors: Lock Christine , Tan Nicole Si Min , Long Ian James , Keong Nicole C.
Published: February 2024

Neuroimaging data repositories are data-rich resources comprising brain imaging with clinical and biomarker data. The potential for such repositories to transform healthcare is tremendous, especially in their capacity to support machine learning (ML) and artificial intelligence (AI) tools. Current discussions about the generalizability of such tools in healthcare provoke concerns of risk of bias—ML models underperform in women and ethnic and racial minorities. The use of ML may exacerbate existing healthcare disparities or cause post-deployment harms. Do neuroimaging data repositories and their capacity to support ML/AI-driven clinical discoveries, have both the potential to accelerate innovative medicine and harden the gaps of social inequities in neuroscience-related healthcare? In this paper, we examined the ethical concerns of ML-driven modeling of global community neuroscience needs arising from the use of data amassed within neuroimaging data repositories. We explored this in two parts; firstly, in a theoretical experiment, we argued for a South East Asian-based repository to redress global imbalances. Within this context, we then considered the ethical framework toward the inclusion vs. exclusion of the migrant worker population, a group subject to healthcare inequities. Secondly, we created a model simulating the impact of global variations in the presentation of anosmia risks in COVID-19 toward altering brain structural findings; we then performed a mini AI ethics experiment. In this experiment, we interrogated an actual pilot dataset (n = 17; 8 non-anosmic (47%) vs. 9 anosmic (53%) using an ML clustering model. To create the COVID-19 simulation model, we bootstrapped to resample and amplify the dataset. This resulted in three hypothetical datasets: (i) matched (n = 68; 47% anosmic), (ii) predominant non-anosmic (n = 66; 73% disproportionate), and (iii) predominant anosmic (n = 66; 76% disproportionate). We found that the differing proportions of the same cohorts represented in each hypothetical dataset altered not only the relative importance of key features distinguishing between them but even the presence or absence of such features. The main objective of our mini experiment was to understand if ML/AI methodologies could be utilized toward modelling disproportionate datasets, in a manner we term “AI ethics.” Further work is required to expand the approach proposed here into a reproducible strategy.
Opinion attribution improves motivation to exchange subjective opinions with humanoid robots
Authors: Uchida Takahisa , Minato Takashi , Ishiguro Hiroshi
Published: February 2024

In recent years, the development of robots that can engage in non-task-oriented dialogue with people, such as chat, has received increasing attention. This study aims to clarify the factors that improve the user’s willingness to talk with robots in non-task oriented dialogues (e.g., chat). A previous study reported that exchanging subjective opinions makes such dialogue enjoyable and enthusiastic. In some cases, however, the robot’s subjective opinions are not realistic, i.e., the user believes the robot does not have opinions, thus we cannot attribute the opinion to the robot. For example, if a robot says that alcohol tastes good, it may be difficult to imagine the robot having such an opinion. In this case, the user’s motivation to exchange opinions may decrease. In this study, we hypothesize that regardless of the type of robot, opinion attribution affects the user’s motivation to exchange opinions with humanoid robots. We examined the effect by preparing various opinions of two kinds of humanoid robots. The experimental result suggests that not only the users’ interest in the topic but also the attribution of the subjective opinions to them influence their motivation to exchange opinions. Another analysis revealed that the android significantly increased the motivation when they are interested in the topic and do not attribute opinions, while the small robot significantly increased it when not interested and attributed opinions. In situations where there are opinions that cannot be attributed to humanoid robots, the result that androids are more motivating when users have the interests even if opinions are not attributed can indicate the usefulness of androids.
Prevalence of Mycobacterium bovis in deer in mainland China: a systematic review and meta-analysis
Authors: Li Dong , Li Dan-Ni , Liu Xin-Yue , Song Yu-Hao , Liu Xue-Tong , Sehrish Siddique , Jia Yu-Xin , Zong Ying , Li Jian-Ming , Shi Kun , Leng Xue , Liu Fei , Diao Nai-Chao , Zeng Fan-Li , Gong Qing-Long , Du Rui
Published: February 2024

Background

Deer tuberculosis is a chronic zoonotic infectious disease, despite the existence of socio-economic and zoonotic risk factors, but at present, there has been no systematic review of deer tuberculosis prevalence in mainland China. The aim of this meta-analysis was to estimate the overall prevalence of deer TB in mainland China and to assess possible associations between potential risk factors and the prevalence of deer tuberculosis.

Methodology

This study was searched in six databases in Chinese and English, respectively (1981 to December 2023). Four authors independently reviewed the titles and abstracts of all retrieved articles to establish the inclusion exclusion criteria. Using the meta-analysis package estimated the combined effects. Cochran’s Q-statistic was used to analyze heterogeneity. Funnel plots (symmetry) and used the Egger’s test identifying publication bias. Trim-and-fill analysis methods were used for validation and sensitivity analysis. we also performed subgroup and meta-regression analyses.

Results

In this study, we obtained 4,400 studies, 20 cross-sectional studies were screened and conducted a systematic review and meta-analysis. Results show: The overall prevalence of tuberculosis in deer in mainland China was 16.1% (95% confidence interval (CI):10.5 24.6; (Deer tuberculosis infected 5,367 out of 22,215 deer in mainland China) 5,367/22215; 1981 to 2023). The prevalence in Central China was the highest 17.5% (95% CI:14.0–21.9; 63/362), and among provinces, the prevalence in Heilongjiang was the highest at 26.5% (95% CI:13.2–53.0; 1557/4291). Elaphurus davidianus was the most commonly infected species, with a prevalence of 35.3% (95% CI:18.5–67.2; 6/17). We also assessed the association between geographic risk factors and the incidence of deer tuberculosis.

Conclusion

Deer tuberculosis is still present in some areas of China. Assessing the association between risk factors and the prevalence of deer tuberculosis showed that reasonable and scientific-based breeding methods, a suitable breeding environment, and rapid and accurate detection methods could effectively reduce the prevalence of deer tuberculosis. In addition, in the management and operation of the breeding base, improving the scientific feed nutrition standards and establishing comprehensive standards for disease prevention, immunization, quarantine, treatment, and disinfection according to the breeding varieties and scale, are suggested as ways to reduce the prevalence of deer tuberculosis.
Comprehensive transcriptomic analysis revealing the regulatory dynamics and networks of the pituitary-testis axis in sheep across developmental stages
Authors: Li Shanglai , Zhao Bingru , Yang Hua , Dai Keke , Cai Yu , Xu Hui , Chen Peiyong , Wang Feng , Zhang Yanli
Published: February 2024

Spermatogenesis is a complex process intricately regulated by the hypothalamic-pituitary-testis (HPT) axis. However, research on the regulatory factors governing the HPT axis remains limited. This study addresses this gap by conducting a comprehensive analysis of transcriptomes from the pituitary and testis tissues across various developmental stages, encompassing embryonic day (E120), neonatal period (P0), pre-puberty (P90), and post-puberty day (P270). Utilizing edgeR and WGCNA, we identified stage-specific genes in both the pituitary and testis throughout the four developmental stages. Notably, 380, 242, 34, and 479 stage-specific genes were identified in the pituitary, while 886, 297, 201, and 3,678 genes were identified in the testis. Subsequent analyses unveiled associations between these stage-specific genes and crucial pathways such as the cAMP signaling pathway, GnRH secretion, and male gamete generation. Furthermore, leveraging single-cell data from the pituitary and testis, we identified some signaling pathways involving BMP, HGF, IGF, and TGF-β, highlighting mutual regulation between the pituitary and testis at different developmental stages. This study sheds light on the pivotal role of the pituitary-testis axis in the reproductive process of sheep across four distinct developmental stages. Additionally, it delves into the intricate regulatory networks governing reproduction, offering novel insights into the dynamics of the pituitary-testis axis within the reproductive system.
Individual and Community-Contextual Level Factors Associated With Wellbeing Among Older Adults in Rural Zambia
Authors: Banda Andrew , Hoffman Jaco , Roos Vera
Published: February 2024

Objective: This article aims to identify individual and community-contextual level factors associated with the wellbeing of older adults (50 years and older) in rural Zambia.

Methods: Data from the nationally representative 2015 Living Conditions Monitoring Survey (LCMS) was used. Employing multilevel mixed effects, the individual and community-contextual factors on wellbeing were determined.

Results: Overall, 31.7% of rural older adults perceived their wellbeing as good. Both individual and community-contextual level factors are associated with the wellbeing of older adults in rural communities. At the individual level, wellbeing was associated with higher education attainment. Community-contextual factors significantly associated with wellbeing included improved housing, access to piped tap water within the premises, own charcoal or income to purchase firewood.

Conclusion: The findings foreground the imperative to analyse both individual and community-contextual level factors of wellbeing to generate and present evidence for investments in education across the life course and for the development of infrastructure towards increasing the wellbeing of rural older adults. Additionally, the results provide a basis for planning by devising policies and programmes for older people to thrive and for no one to be left behind regardless the setting.
Cross-Sectional but Not Prospective Association of Accelerometry-Derived Physical Activity With Quality of Life in Children and Adolescents
Authors: Darkhawaja Ranin , Hänggi Johanna , Schaffner Emmanuel , Kwiatkowski Marek , Alkaiyat Abdulsalam , Dössegger Alain , Kayser Bengt , Suggs L. Suzanne , Bringolf-Isler Bettina , Probst-Hensch Nicole
Published: February 2024

Objectives: This study aims to quantify the cross-sectional and prospective associations between quality of life (QoL) and moderate-to-vigorous physical activity (MVPA).

Methods: This study was based on the Swiss children’s Objectively measured PHYsical Activity cohort. The primary endpoint is the overall QoL score and its six dimensions. The main predictor is the average time spent in MVPA per day. Linear mixed effects and linear regression models respectively were used to investigate the cross-sectional and prospective associations between MVPA and QoL.

Results: There were 352 participants in the study with complete data from baseline (2013–2015) and follow-up (2019). MVPA was positively associated with overall QoL and physical wellbeing (p = 0.023 and 0.002 respectively). The between-subject MVPA was positively associated with the overall QoL, physical wellbeing, and social wellbeing (p = 0.030, 0.017, and 0.028 respectively). Within-subject MVPA was positively associated with physical wellbeing and functioning at school (p = 0.039 and 0.013 respectively). Baseline MVPA was not associated with QoL 5 years later.

Conclusion: Future longitudinal studies should employ shorter follow-up times and repeat measurements to assess the PA and QoL association.
Development of Tools for Expanding the Use of Virtual Reality (VR) Technology in the Field of Construction Site Fall Protection
Authors: Bakai Nándor , Zagorácz Márk Balázs , Rák Olivér , Hillebrand Péter
Published: February 2024

In the construction industry, the occurrence of work accidents is considered to be a critical issue. With advancements in technology, various innovative tools and methodologies have emerged that may provide solutions to mitigate this risk. One of these technologies could be virtual reality that has the potential to enhance worker safety by providing a controlled environment for practicing relevant safety tasks during safety training. The objective of the research and development was to create a system that links fall protection equipment in the physical environment with the virtual space. This study presents a comprehensive examination of the methodology, outcomes of the tool development, and the evaluation of this system.
KUKA KR3 Industrial Robot Unit HMI Design and Control with Universal Industrial PC in Sipy Development Environment
Authors: Diós Szabolcs Sándor , Asztalos Gergő Tamás , Husi Géza
Published: February 2024

The challenges presented by Industry 4.0 require an innovative, new type of thinking from the engineers. Connecting old machines into a network presents significant problems, as the switch cabinets for these are obsolete and non-upgradeable. This has made developing a solution necessary, that is later universally applicable for scrapped, but mechanically intact robot arms. During the realization of the project such an IoT compatible graphical interface was developed, which can control a KUKA KR3 industrial robot unit and can also Real-Time simulate it in virtual reality. The security functions of the robot are provided by a Pycom SiPy developer panel.
How Do Digital Capabilities Affect Organizational Performance in the Public Sector? The Mediating Role of the Organizational Agility
Authors: Atobishi Thabit , Moh’d Abu Bakir Sahar , Nosratabadi Saeed
Published: February 2024

As public sector agencies face rising imperatives to digitally transform citizen services, data systems, and internal operations, questions persist as to whether investments in big data analytics and automation capabilities, evidenced to drive organizational performance in private industry, translate to bureaucratic government contexts. This research quantitatively investigates the link between digital capabilities and organizational performance in the Jordanian ministry of Justice. Survey data collected from 292 public officials assessed capabilities in data-driven decision making, flexible automation, and interactive constituent communications alongside organizational agility and performance indexes spanning efficiency, quality, and satisfaction metrics. Structural equation modeling analysis reveals that digital capabilities relate significantly to heightened agility and all targeted performance areas. Improved agility mediates over half the performance impact attributable to upgraded technical systems, highlighting the vital role of evolving digitally enabled flexibility in realizing returns on analytics and process modernization initiatives. Findings validate the applicability of conclusions on digitization returns formed in corporate environments to public sector contexts, contingent on bundled change management programming enabling both technical and adaptive capacity building across the workforce. As global regions expand e-governance programs premised on harnessing emerging technologies to enhance civic institutions, this research offers generalizable models guiding multifaceted preparations to amplify impact.
Dynamic Response Mechanism of Ethanol Atomization–Combustion Instability under a Contrary Equivalence Ratio Adjusting Trend
Authors: Tao Chengfei , Sun Rongyue , Wang Yichen , Gao Yang , Meng Lin , Jiao Liangbao , Liang Shaohua , Chen Ling
Published: February 2024

This study experimentally explored the effects of equivalence ratio settings on ethanol fuel combustion oscillations with a laboratory-scale combustor. A contrary flame equivalence ratio adjusting trend was selected to investigate the dynamic characteristics of an ethanol atomization burner. Research findings denote that optimizing the equivalence ratio settings can prevent the occurrence of combustion instability in ethanol burners. In the combustion chamber, the sound pressure amplitude increased from 138 Pa to 171 Pa and eventually dropped to 38 Pa, as the equivalence ratio increased from 0.45 to 0.90. However, the sound pressure amplitude increased from 35 Pa to 199 Pa and eventually dropped to 162 Pa, as the equivalence ratio decreased from 0.90 to 0.45. The oscillation frequency of the ethanol atomization burner presents a migration characteristic; this is mainly due to thermal effects associated with changes in the equivalence ratio that increase/decrease the speed of sound in burnt gases, leading to increased/decreased oscillation frequencies. The trend of the change in flame heat release rate is basically like that of sound pressure, but the time-series signal of the flame heat release rate is different from that of sound pressure. It can be concluded that the reversible change in equivalence ratio will bring significant changes to the amplitude of combustion oscillations. At the same time, the macroscopic morphology of the flame will also undergo significant changes. The flame front length decreased from 25 cm to 18 cm, and the flame frontal angle increased from 23 to 42 degrees when the equivalence ratio increased. A strange phenomenon has been observed, which is that there is also sound pressure fluctuation inside the atomized air pipeline, and it presents a special square waveform. This study explored the equivalence ratio adjusting trends on ethanol combustion instability, which will provide the theoretical basis for the design of ethanol atomization burners.