bluuebunny/crossref_metadata_2025 huggingface dataset:
Tinjauan Masalah Kecemasan: Studi pada Lansia dengan Insomnia
Authors: Sintiya Melan Noer , Priasmoro Dian Pitaloka , Wahyu Ardhiles
Published: October 2024

Pendahuluah: Lansia sangat rentan terhadap gangguan pola tidur (insomnia). Gangguan tidur dan kekurangan tidur dapat merangsang kesulitan emosional yang dapat meningkatkan keadaan stres dan kecemasan secara subjektif serta meningkatkan reaksi simpatetik terhadap stimulus yang tidak menyenangkan.Tujuan penelitian adalah untuk mengetahui gambaran tingkat kecemasan pada lansia yang mengalami insomnia di Dusun Gampingan Rw 07 Wonokerto Kecamatan Bantur.
Metode: Penelitian ini merupakan penelitian kuantitatif dengan desain deskriptif. Populasi nya adalah seluruh lansia di Desa Gampingan Rw 07 Wonokerto sejumlah 75 orang. Sampel penelitian sejumlah 40 responden yang didapatkan dengan purposive sampling. Alat ukur menggunakan kuesioner HARS. Penelitian dilakukan pada 1 – 10 Mei 2023. Analisis data menggunakan analisis univariat.
Hasil: Hasil penelitian ini diperoleh bahwa sebagian besar lansia yang insomnia mengalami mengalami cemas berat 19 responden (47.55%), hampir setengahnya mengalami kecemasan sedang 13 responden (32.5%) ,sebagian kecil mengalami kecemasan ringan 5 responden (12.5%), dan sebagian kecil tidak ada kecemasan 3 responden (7.5%). Faktor yang mempengaruhi kecemasan pada lansia adalah umur, jenis kelamin, riwayat pendidikan, pekerjaan, dan mengonsumsi kafein.
Kesimpulan: Penting untuk memahami penyebab insomnia pada lansia. Kecemasan dapat menjadi akibat insomnia yang berkepanjangan. Lansia yang mengalami insomnia dan kecemasan juga dapat mempertimbangkan perubahan gaya hidup sehat, seperti menghindari kafein sebelum tidur, berolahraga secara teratur, dan menjaga pola hidup sehat.
Self-Organized Operational Neural Networks for Early Glaucoma Diagnosis in Digital Fundus Images
Authors: ASHWINI Mrs. , SAIKUMAR SAIKUMAR
Published: October 2024

Glaucoma leads to permanent vision disability by damaging the optical nerve that transmits visual images to the brain. The fact that glaucoma does not show any symptoms as it progresses and cannot be stopped at the later stages, makes it critical to be diagnosed in its early stages. Although various deep learning models have been applied for detecting glaucoma from digital fundus images, due to the scarcity of labeled data, their generalization performance was limited along with high computational complexity and special hardware requirements. In this study, compact Self-Organized Operational Neural Networks (Self-ONNs) are proposed for early detection of glaucoma in fundus images and their performance is compared against the conventional (deep) Convolutional Neural Networks (CNNs) over three benchmark datasets: ACRIMA, RIM-ONE, and ESOGU. The experimental results demonstrate that Self-ONNs not only achieve superior detection performance but can also significantly reduce the computational complexity making it a potentially suitable network model for biomedical datasets especially when the data is scarce.
Breast Cancer Detection System Using Machine Learning
Authors: Acharya B Dr. Ganesha
Published: October 2024

This study, titled "Students' Attitudes in the Post-COVID Era: A Study on the Impact of Online Learning during the COVID-19 Pandemic," explores the effects of the rapid shift to online learning on students' attitudes, experiences, and future expectations in education. The COVID-19 pandemic forced educational institutions worldwide to adopt online learning models, which significantly altered the traditional dynamics of teaching and learning. This research investigates how students from diverse educational levels and backgrounds responded to these changes, examining both the positive and negative aspects of online learning. A mixed-methods approach was used, combining quantitative data from 400 students through surveys. Key findings reveal that while students appreciated the flexibility and convenience of online learning, many struggled with engagement, technical difficulties, and feelings of isolation. The study also highlights how socioeconomic factors and access to technology influenced students’ experiences, with those from underprivileged backgrounds facing greater challenges. A significant portion of students expressed a preference for blended learning models, which integrate both online and in-person elements. The research concludes that online learning has the potential to enhance education if critical challenges such as the digital divide, mental health support, and hands-on learning deficiencies are addressed. The study’s recommendations focus on adopting flexible learning approaches, improving digital infrastructure, and providing better support for both students and educators in the evolving educational landscape. This study provides valuable insights into the future of education post-pandemic and suggests that, with the right interventions, the digital transformation in education can lead to more inclusive and effective learning environments.
A Review On Multi objective Optimisation of Process Parameters in Shielded Metal Arc Welding For Joining Stainless Steel 3041 And Mild Steel 1018
Authors:   PG Student Mechanical Engineering Department, Deogiri Institute of Engineering and Management Studies,  Chhatrapati Sambhajinagar Aurangabad, Maharashtra., T Shembde Mr. Mahesh , Borse Dr. S.C ,   PG Student Mechanical Engineering Department, Deogiri Institute of Engineering and Management Studies,  Chhatrapati Sambhajinagar Aurangabad, Maharashtra.
Published: October 2024

Due to Mechanical properties of the welding metal and heat affected zone (HAZ) is quality of welding in this research work the review of Multi-objective optimization of welding process parameters for obtaining best weld strength with good mechanical properties of dissimilar metals like stainless steel 3041 and Mild steel 1018 is done. This process used for welding is shielded Metal Arc welding and dissimilar metal are stainless steel 3041 and mild steel 1018. Welding speed, depend on electric property like current Voltage electrode angle, feed rate, Arc length are taken as controlling variables. The weld strength (N/mm2) and Bead geometry variables and Heat Affected Zone are obtained by set of experiment, the possible best outcomes and best method has been chosen by this research. Keywords: HAZ, Multi objective optimization, Response surface Methodology, Shielded metal arc welding
Retrofitting Techniques: A Comprehensive Review
Authors: Mohankar Mr. Roshan H
Published: October 2024

The need of improving the structural performance of old constructed structures has grown significantly as a result to increasing concerns over deteriorating infrastructure, changing building codes and natural calamities. Retrofitting is one of the best processes to make an existing building safe against future coming earthquakes or other environmental forces. Retrofitting is the process of adding new features to older buildings, bridges and many other structures. It aims to strengthen the structure, to satisfy the load carrying capacity of structure and seismic design. This paper includes study of research papers published in past years related to various methods of retrofitting such as seismic retrofitting, retrofitting by glass fibers, retrofitting by chemicals such as epoxy resin and many other methods. Structures lose their strength in some years, some structures are important in view of public, social or any historical. Retrofitting helps to increase the strength, resistivity and lifespan of structure. Key Words: Retrofitting, Strength, Safety.
RescueNow: Real-time SOS and Predictive Women's Safety System
Authors: Navale Dr. Mahesh
Published: October 2024

This paper presents a comprehensive women’s safety application designed to address the growing concerns of personal safety through technological intervention. The system integrates multiple advanced features such as real-time SOS alerts, geofencing to detect high-risk areas, AI-driven crime predictions, and multiple SOS activation methods, including voice commands, shake detection, and button press. Additionally, the app employs silent recording functionality to gather evidence in distress situations and incorporates secure communication channels for contacting law enforcement. The application also supports community-driven safety ratings and crime reporting. Tested with real-world scenarios, the system demonstrates high accuracy in predictive analytics and provides a seamless, scalable solution for enhancing women’s safety. This project contributes to the field of personal safety technologies by introducing a multi-faceted, AI-enabled framework for real-time risk mitigation. Key Words: Women’s safety, SOS alerts, AI crime prediction, geofencing, real-time GPS tracking, predictive analytics, Firebase Cloud Messaging, Twilio, silent recording, crime reporting.
Trefoil Factor 3 in human serum as a predictor of disease activity in Egyptian ulcerative colitis patients and its role in colorectal cancer
Authors:   Department of Gastroenterology, Hepatology & Internal Medicine, Faculty of Medicine, Ain Shams University, Cairo, Egypt., Abd El Malak Mina
Published: October 2024

Ulcerative colitis (UC), a chronic idiopathic inflammatory disease, is caused by abnormal immune response to intestinal microflora. Colorectal cancer (CRC) is one of the leading causes of cancer-related mortality. The gold standard to establish diagnosis and assess disease activity remains endoscopy and histopathology. Non-invasive biomarkers are required for timely diagnosis of CRC and to assess disease activity as endoscopic assessment is not accepted by most patients. Enhanced trefoil factor 3 (TFF3) expression is seen following gastrointestinal tract injury. In the current study, the significance of serum TFF3 as a potential diagnostic biomarker of disease activity in naїve UC patients, and its diagnostic accuracy in CRC patients were investigated. We collected serum and fecal samples from 20 cases with active UC, 20 CRC patients, and 20 normal controls. TFF3 levels were higher in patients with active UC than in controls (p<0.001). TFF3 cut-off value of 7.9 ng/ml could predict disease activity with sensitivity and specificity of 90% and 100%, respectively. However, the combination of TFF3, C-reactive protein (CRP), and fecal calprotectin (FC) was able to predict disease activity better than each biomarker alone by raising the sensitivity and specificity to 100%. There was no correlation between TFF3, FC, and endoscopic activity in UC assessed by ulcerative colitis endoscopic index of severity (UCEIS). In the CRC patient group, the serum level of TFF3 was significantly higher when compared to controls (p=0.012). TFF3 and the degree of dysplasia were significantly correlated (r=0.496, p=0.026). At a cut-off value of 5.9 ng/ml, serum TFF3 had a diagnostic sensitivity and specificity for CRC of 82% and 90%, respectively. In conclusion, serum TFF3 may be used as a non-invasive biomarker to predict disease activity in UC both alone and in combination with CRP and FC and it could have a potential role in diagnosis of CRC.
Association of BLK and BANK1 gene polymorphisms with systemic lupus erythematous in Egyptian patients
Authors:   Department of Internal Medicine, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt., Mohammed Rehab
Published: October 2024

This study examined the genotype, allelic frequencies (polymorphisms) in a sample of Egyptian patients and examined the relationship between disease activity in systemic lupus erythematosus (SLE) and the B lymphoid tyrosine kinase (BLK) and B-cell scaffold protein with ankyrin repeats 1 (BANK1) gene. This case control study involved 70 SLE patients and 40 subjects matched for age and sex as a control group. Clinical data were gathered from each participant, including SLE-related clinical activity indicators. Utilizing the restriction fragment length polymorphism (RFLP)-polymerase chain reaction (PCR), the single nucleotide polymorphisms (SNPs) BLK rs13277113G/A and BANK1 rs10516487G/A were assessed. The most prevalent genotype among the study participants was BLK rs13277113; G/G (57.1%), and BANK rs10516487; GG/ genotype (74.3%). There were no substantial variations in the incidence of genotype and allelic polymorphism between patients and controls (p>0.05). In the studied SLE patients, however, there was no significant association between both alleles (BANK rs10516487 gene alleles, G/G and G/A & BLK rs13277113, G/A, G/G &A/A) and the SLE disease activity score. While there was a significant association between BLK rs13277113 genotype alleles and age. In conclusion, BLK rs13277113 G/A and BANK1 rs10516487 G/A alleles showed no difference between SLE Egyptian patients compared to controls with no link between both genes and SLE disease activity.
Physiology and immunology of the adrenergic anti-inflammatory pathway
Authors:   Department of Biomedical & Dental sciences, Faculty of Dentistry, Al-Baha University, Saudi Arabia., Aboulata Alaa
Published: October 2024

The adrenergic anti-inflammatory pathway represents a critical intersection between the nervous and immune systems, modulating the body's response to inflammation through the action of catecholamines on adrenergic receptors. This review explored the physiology underlying this pathway, focusing on the mechanisms by which the sympathetic nervous system influences immune function. We delved into the roles of specific adrenergic receptors, primarily the beta-adrenergic receptors, in mediating anti-inflammatory effects, highlighting the involved molecular signaling pathways. Additionally, we examined the immunological implications of adrenergic modulation, discussing how these pathways contributed to the resolution of inflammation and the potential for dysregulation in various disease states. Emerging evidence on the therapeutic potential of targeting the adrenergic anti-inflammatory pathway in conditions such as sepsis, autoimmune diseases, and chronic inflammatory disorders was also reviewed. By integrating current knowledge on the physiology and immunology of this pathway, this review aimed to provide a comprehensive understanding of its role in health and disease, offering insights into future research directions and clinical applications.
Assessment of synovial repair in primary knee osteoarthritis after platelet rich plasma (PRP) intra-articular injection
Authors:   Department of Physical Medicine, Rheumatology & Rehabilitation, Faculty of Medicine, Ain Shams University, Cairo, Egypt., Bastawy Esraa
Published: October 2024

Primary knee osteoarthritis (KOA) is a persistent condition marked by the gradual deterioration of the joint and cartilage loss on its surfaces. Recently, platelet-rich plasma (PRP) was considered a biological intervention that alleviates symptoms and restricts the advancement of primary KOA in patients. This study aimed to evaluate the effect of intra-articular PRP injections on synovial repair through cytokine assays in 20 patients with primary KOA. Patients received two intra-articular PRP injections, spaced one month apart. The role of PRP was assessed by measuring Transforming growth factor beta (TGF-β) and interleukin-17 (IL-17) levels in synovial fluid before and after the injections. Both visual analogue scale and Western Ontario and McMaster Universities Osteoarthritis index were assessed before and after intervention. IL-17 and TGF-β levels were measured in the synovial fluid using sandwich ELISA technique before the first PRP intra-articular injection and one month after the second injection to assess the synovial repair after PRP injection. Our results showed that the synovial IL-17 levels significantly decreased by 75.21% (p<0.0001) after intra-articular knee injection, dropping from a range of 102.3–293 (median 173.5: 139.7– 224.5) to 17.86–106 (median 36.38: 23.57– 50.32). In contrast, synovial TGF-β levels significantly increased by 80.3% (p<0.0001) after intra-articular knee injection, rising from 124–545.5 (mean ± SD: 256.22 ± 123.56) to 693.3–3226 (mean ± SD: 1521.6 ± 765.46). In conclusion, intra-articular PRP administration in primary KOA patients is associated with increased levels of TGF-β and decreased levels of IL-17 in the synovial fluid of the joint. These changes in cytokine levels suggest that PRP treatment effectively reduces inflammation and may contribute to pain relief in primary KOA.
Effectiveness of zero dose HBV vaccine on prevention of HBV breakthrough infection among vaccinated Egyptian children
Authors:   Department of Medical Microbiology & Immunology, Faculty of Medicine (for girls), Al-Azhar University, Cairo, Egypt., Abu shady Eman
Published: October 2024

Hepatitis B virus (HBV) is a vaccine preventable disease. Sufficient post vaccination response is critical step to achieve infection eradication. Vaccine hypo-responsiveness is a major risk factor for HBV chronic infection. We aimed to evaluate the effectiveness of birth dose HBV vaccine in preventing perinatal HBV infection and to detect the rate of HBV surface antibody (HBs-Ab) seroconversion and its relation to interleukin-4 polymorphism (IL-4 PM) among a group of vaccinated Egyptian infants. This observational analytical study involved 77 infants aged 6 to 12 months who received 4 doses of HBV vaccine including a zero dose. We measured serum levels of HBV-DNA and hepatitis B surface antigen (HBsAg) as markers of infectivity, and the level of (HBsAb) to assess vaccine responsiveness. Cytokine gene analysis to detect IL-4 gene polymorphism and its association with vaccine un-responsiveness were investigated. We observed that none of the vaccinated infants acquired HBV infection. Of the included 77 infants, seroconversion against HBV was detected in 72 (93.5%), 28 (36.4%) had low response and 44 (57.1%) had high response. While 5 (6.5%) were non responders. There was significant association between IL-4 gene polymorphism and the poor seroconversion after HBV vaccination. (p=0.03). Furthermore, HBsAb titer was significantly lower in children who have IL-4 gene polymorphism (p=0.014). In conclusion, implementation of birth-dose HBV vaccination is effective for prevention of perinatal infection, but seroconversion rate may be insufficient to induce long term protection. IL-4 gene polymorphism is associated with poor response to HBV vaccine.
Physiological and hormonal changes between postmenopausal rheumatoid arthritis and systemic lupus erythematosus in women
Authors:   Department of Biology, College of Science, Mustansiriyah University, Baghdad, Iraq., Jouda Jamela
Published: October 2024

It is thought that sex hormones are playing an actual role in the pathogenesis of rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). The purpose of this study was to determine the differences of some hematological, hormonal and immunological parameters between the postmenopausal women with rheumatoid arthritis and systemic lupus erythematosus. This study contained 75 postmenopausal women (52-65 years old). They included 25 women diagnosed with rheumatoid arthritis, 25 diagnosed with systemic lupus erythematosus and 25 normal controls. Blood was collected and used to determine complete blood count (CBC) and erythrocyte sedimentation rate (ESR) tests. Serum was separated and used to determine Follicle-stimulating hormone (FSH), Luteinizing Hormone (LH), Prolactin, cortisol, Estrogen, progesterone, testosterone, rheumatoid factor (RF) and Immunoglobulin E (IgE). The results indicated that both patients’ groups had anemia. However, the RA group had leukocytosis, but the SLE group had leukopenia. Moreover, thrombopenia occurred only in SLE patients. Although the levels of FSH and cortisol were significantly higher, the levels of LH, Estrogen and testosterone had significantly dropped in both patient groups. Interestingly, the level of progesterone was higher in the SLE and lower in the RA group. Moreover, the levels of RF, ESR and IgE were significantly increased in both patients’ groups. In conclusion, there were many differences in hematological and hormonal levels between postmenopausal women with rheumatoid arthritis and systemic lupus erythematosus. Such findings need future work to find out the reasons for these differences and how they could be used in future treatment strategies.
The impact of achieving remission in inflammatory bowel disease on plasma matrix -carboxyglutamate protein levels
Authors:   Department of Internal Medicine, Gastroenterology & Hepatology Unit, Faculty of Medicine, Ain Shams University, Cairo 11591, Egypt., Mohamed Ghada
Published: October 2024

Matrix -carboxyglutamic acid (MGLA) protein is a vitamin K dependent peptide which contributes to the immunomodulatory activity of mesenchymal stromal cells. There is a possible association between MGLA protein and inflammatory bowel disease (IBD) which is divided into Crohn’s disease (CD) and ulcerative colitis (UC). However, little is known about the clinical utility of MGLA protein in IBD patients. This study aimed to assess the impact of achieving remission on the serum MGLA protein levels in IBD patients. This prospective observational study included 60 newly diagnosed IBD patients. All patients were subjected to full clinical, laboratory, radiological, and histopathological assessment of IBD at baseline and six months after initiating treatment. Serum MGLA protein level was assessed using an enzyme-linked immunosorbent assay. There were 29 (48.3%) UC cases and 31 (51.67%) CD cases. We observed a significant decrease in serum MGLA protein levels after 6 months of treatment compared to pretreatment values in UC patients (120.490 ± 26.273 vs. 26.320 ± 17.378 nmol/L, p<0.001) and CD patients (125.576 ± 28.208 vs. 28.520 ± 18.443 nmol/L, p<0.001). Serum MGLA protein levels were significantly higher in non-remittent patients compared to remittent UC patients before treatment (142.556 ± 17.096 vs. 110.560 ± 23.659 nmol/L, p<0.001) and after six months of treatment (51.222 ± 4.410 vs. 15.114 ± 3.302 nmol/L, p<0.001). Serum MGLA protein levels were significantly higher in non-remittent patients compared to remittent CD patients before treatment (150.727 ± 7.198 vs. 111.743 ± 25.718 nmol/L, p<0.001) and after six months of treatment (52.182 ± 5.269 vs. 15.506 ± 4.475 nmol/L, p<0.001). This response was irrespective of the therapeutic modality. In conclusion, achievement of remission in IBD patients resulted in a significant decrease in serum MGLA protein levels.
A study on serum zonulin in chronic spontaneous urticaria patients
Authors:   Department of of Internal Medicine, Allergy & Clinical Immunology, Faculty of Medicine, Ain Shams University, Cairo, Egypt., Mohamed Mariam
Published: October 2024

hronic spontaneous urticaria (CSU) is a widespread disease with a complicated heterogenous pathophysiology. Increased intestinal permeability i.e., leaky gut has been linked to the pathology of many diseases. Zonulin was recently used as a marker for leaky guts. This study aimed to assess the relation between serum zonulin level and CSU and its possible relationship with disease activity. This was a comparative cross-sectional study, which included 97 CSU adult patients and 87 apparently healthy controls. CSU patients had significant lower zonulin level than controls (p<0.001). The median of serum zonulin level was equal to 2.93 ng/ml with interquartile range (IQR) (1.40-4.19) in the CSU group and of 3.92 ng/ml with IQR (2.97-4.69) in the control group. We found a positive correlation between serum zonulin and C-reactive protein with Pearson correlation coefficient of 0.2, (p=0.04). No significant correlation was found between serum zonulin level and urticaria activity score 7 or total immunoglobulin E level. In conclusion, this study found that serum zonulin level is lower in CSU patients than in controls which could be attributed to food restriction, severity of the CSU disease and/or drug intake in the CSU cases.
Knowledge, attitude, and practice toward rheumatic fever and rheumatic heart disease among parents in Al-Baha Region, Saudi Arabia: A Cross-Sectional study
Authors:   Department of Pediatrics, Faculty of Medicine, Al-Baha University, Al-Baha, Saudi Arabia., Mohammed Khalid
Published: October 2024

untreated group A streptococcal pharyngitis and primarily affects children. It can lead to rheumatic heart disease (RHD), a major cause of cardiovascular morbidity and mortality. Awareness and preventive measures are crucial to mitigate its impact, particularly in low-resource settings. This study aimed to assess the knowledge, attitudes, and practices toward RF and RHD among parents living in Al-Baha Region. And to determine its association with other different sociodemographic variables. This was a cross-sectional study included 415 parents in Al-Baha region, Saudi Arabia. using a self-administered questionnaire distributed online. Of the total 415 participants, more than half were females 223 (53.7%), and 149 (35.9%) participants aged between 45 and 55 years. The knowledge regarding RF was classified as good 20 (4.8%), fair 104 (25.1%), and bad 291 (70.1%). The attitude towards RF showed that about half of the participants 206 (49.7%) had a negative attitude, 169 (40.7%) natural and 40 (9.6%) positive attitudes. While the total practice level was classified as Bad 15 (3.6%), Fair 113 (27.2%) and Good 287 (69.2%), females were more likely than males to exhibit good practices (p = 0.001). The study concluded that knowledge about RF and RHD among parents in the Al Baha region, Saudi Arabia, is very poor. Most participants lacked sufficient understanding of the definition of RF, its relationship with bacterial sore throats, prophylactic treatments, and the vulnerable age group. Attitudes towards RF were relatively negative. Therefore, healthcare authorities and providers should raise awareness and create educational programs to improve public understanding of RF and RHD, aiding in their prevention and control in the Al Baha region.
Serum thymosin beta 10 level as a potential prognosis prediction of hepatocellular carcinoma and hepatic diseases
Authors:   Department of Biochemistry Division, Department of Chemistry, Faculty of Science, Zagazig University, Zagazig, Egypt., EL Ksass Arwa
Published: October 2024

Thymosin Beta 10 (TMSB10) is a thymosin family member that has been identified as being overexpressed in a wide variety of human cancers. This study aimed to determine the expression level of TMSB10 in sera of patients with hepatocellular carcinoma (HCC) and liver cirrhosis. And to reveal the association between TMSB10 and different stages in patients with HCC. We also wanted to know how TMSB10 is predictive in HCC patients and its relation to the Barcelona Clinic's staging system. The study included 41 HCC patients, 15 liver cirrhosis patients, and 15 normal control subjects. The enzyme-linked immunosorbent assay was used to determine serum levels of TMSB10 and alpha-fetoprotein (AFP) in serum of normal control individuals and patients with liver cirrhosis and different stages of HCC, and to evaluate the relationship of AFP with TMSB10. The TMSB10 levels in patients with HCC were statistically different than in the control group and in the different stages of HCC. We found a statistically significant difference in the distribution of TMSB10 between the three study groups (p< 0.001). There was an association between TMSB10 concentration and AFP. The level of TMSB10 in the serum of the HCC subgroups was then analyzed. The TMSB10 level increased with the advance of HCC stages. The TMSB10 level in HCC patients did not correlate with levels of liver function tests including aminotransferase, aspartate aminotransferase, albumin, prothrombin, bilirubin, or alkaline phosphatase. In conclusion, serum TMSB10 levels can be used as a potential prognostic marker for clinical stages of HCC.
TRANSPORT CORRIDORS OF CENTRAL ASIA IN THE SOCIO-ECOLOGICAL DIMENSION
Authors: Shadimetov Yusufzhan , Ayrapetov Dmitriy
Published: October 2024

The article examines the socio-ecological aspects of creating transport corridors in Central Asia in the modern context. The region's unique geographical position has long attracted attention, becoming a key link between East and West, particularly along the historical Silk Road. In this regard, the environmental optimization of transport corridors is crucial for sustainable regional development. However, the increase in freight traffic amplifies human impact on the environment, leading to air, water, and soil pollution, as well as changes in the soil's chemical composition and microflora.
The article offers recommendations to minimize the negative effects of multimodal transport corridors on the region’s ecosystem, a necessary step toward balancing economic growth with environmental preservation.
СОҒЛИҚНИ САҚЛАШ СОҲАСИНИ ДАВЛАТ-ХУСУСИЙ ШЕРИКЛИК АСОСИДА МОЛИЯЛАШТИРИШ
Authors: Касимова Гуляр
Published: October 2024

Мақолада соғлиқни сақлаш соҳасини молиялаштириш шаклларидан бири – давлат-хусусий шериклик ҳақидаги назарий ёндашувлар тадқиқ қилинган. Соғлиқни сақлаш  соҳасида  инфратузилма лойиҳаларини молиялаштиришда давлат-хусусий шериклик механизмини қўллаш масаласи хорижий экспертларнинг ишларида ўрганилган. Европа Иттифоқи мамлакатларида давлат ва хусусий шериклик асосида  соғлиқни сақлаш тизимини молиялаштириш  улуши ҳамда Ўзбекистон Республикасида  соғлиқни сақлаш соҳасида амалдаги давлат ва хусусий шериклик шакллари ҳақида ҳам тўхталиб ўтилган.  Давлат ва хусусий шериклик  шартномаларини  тузиш  орқали  ижтимоий инфратузилма лойиҳаларини  амалга  ошириш афзалликлари кўрсатилган ҳамда давлат ва хусусий шериклик  механизмига муаллифлик ёндашуви ва қарашлари баён этилган.
ISSUES OF FORMATION OF A MANAGEMENT MECHANISM FOR ENTREPRENEURSHIP UNIVERSITIES IN THE CONDITIONS OF TRANSFORMATION OF THE ECONOMY OF UZBEKISTAN
Authors: Lyamkina Viktoriya
Published: October 2024

In a constantly changing economic system, entrepreneurial universities are becoming a priority in the education and innovation system. This article examines the process of forming a management mechanism for an entrepreneurial university in the context of economic transformation. The formation of an effective management mechanism for an entrepreneurial university requires an integrated approach that takes into account internal and external development factors. The author examines the essence of the management mechanism and methods of influencing this mechanism within the framework of the entrepreneurial model of higher educational institutions.
РАҚАМЛИ ИҚТИСОДИЁТ ШАРОИТИДА КОРХОНАЛАРДА ТИЖОРАТ РИСКЛАРИНИ ТАДҚИҚ ЭТИШНИНГ ДОЛЗАРБ МАСАЛАЛАРИ
Authors: Шарипова Гулмира
Published: October 2024

Мақолада рақамли иқтисодий шароитларда корхоналарда тижорат рискларини тадқиқ этишнинг назарий жиҳатлари тадқиқ қилинган бўлиб, корхоналар фаолиятининг барқарорлигини таъминлаш мақсадида риск, таваккалчилик, хавф-хатар, ноаниқлик каби тушунчаларнинг ҳам иқтисодий моҳиятини ёритиб берилган ҳамда тижорат рискларининг келиб чиқишини рағбатлантирадиган омилларни аниқлаш ва бартараф этиш, ушбу рисклар билан боғлиқ зарар(фойда) миқдорини ва меъёрий даражасини аниқлаш, тижорат рискларини йўқотиш, суғурталаш ва диверсификациялаш имконияларини кенгайтириш бўйича риск-менежмент тизимини қўллаш масалалари таклиф қилинган.
MARKAZIY OSIYO DAVLATLARIDA IQTISODIY O‘SISHNING ASOSIY OMILLARI
Authors: Kuldasheva Zebo
Published: October 2024

Tashqi savdo iqtisodiy taraqqiyotning eng muhim jihatlaridan biri bo‘lib, Markaziy Osiyo iqtisodiyotining rivojlanishi savdoga juda bog‘liq hisoblanadi. Global miqyosda jadal iqtisodiy o‘sishga qaramay, dengizga chiqish imkoniyati mavjud emas mamlakatlar hanuzgacha jahon bozorlariga kirishda bir qator to‘siqlarga duch kelishmoqda. Shu munosabat bilan, mazkur tadqiqot savdo ochiqligi va inson kapitalining 1995 yildan 2021 yilgacha Markaziy Osiyo mamlakatlari iqtisodiy taraqqiyotiga ta'sirini o‘rganadi. FMOLS va DOLS metodikasi orqali elektr energiyasi iste'moli, savdo ochiqligi, aholi o‘sishi, to‘g‘ridan-to‘g‘ri xorijiy investitsiyalar va inson kapitali sezilarli darajada iqtisodiy o‘sishga hissa qo‘shadi. Shu o‘rinda ta’kidlash lozimki, axborot texnologiyalarining takomillashib borishi Markaziy Osiyo mamlakatlaring iqtisodiy taraqqiyotga erishishini ma’lum bir darajada pasaytiradi. Siyosat vakillari tomonidan erkin savdo kelishuvlarini, soliq yukini kamaytirish siyosati va ta'limni yanada rivojlantirishga urg‘u berish orqali iqtisodiy o‘sishni barqarorlashtirish mumkinligi tavsiya etiladi.
MАHАLLIY BYUDJЕTLАR MОLIYАVIY BАRQАRОRLIGINI TА’MINLАSH YО‘LLАRI
Authors: Mirzaaxmedov Nodirbek
Published: October 2024

Ushbu maqolada hududiy siyоsаtni ishlаb сhiqish vа аmаlgа оshirish, investitsiyа vа bоshqа sоhаlаrdа dаvlаt dаrаjаsidа qаrоrlаr qаbul qilish uсhun аsоs bоʻlib xizmаt qilаdi. Shu bilаn birgа, hududlаr mоliyаviy resurslаri vа iqtisоdiy sаlоhiyаtini, ulаrning mоliyаviy bаrqаrоrlik dаrаjаsi mаmlаkаtimizdа biznes yuritishni mаqsаd qilgаn xоrijiy tаdbirkоrlаrdа qiziqish uyg‘оtishi mumkin. Shuning uсhun mаhаlliy byudjetlаrning mаrkаz byudjetigа qаrаmligini keskin kаmаytirish, byudjetlаrаrо munоsаbаtlаrni tubdаn islоh qilish vа mаhаlliy byudjetlаr mаblаg‘lаrini sаmаrаli bоshqаrishdа jоylаrdаgi dаvlаt hоkimiyаti оrgаnlаrining mustаqil ish оlib bоrishlаrini tа’minlаsh muhim оmil hisоblаnаdi. Bundа mаhаlliy byudjetlаrning оʻz dаrоmаdlаri bаzаsini kengаytirish, xаrаjаt mаjburiyаtlаrini орtimаllаshtirish аsоsidа ulаrning mоliyаviy bаrqаrоrligini tа’minlаsh muhim ahamiyatga ega bo‘lgan masalalardan biri hisoblanadi.
UY-JОY FОNDLARINI BОSHQARISH KОMPANIYALARINING TASHKILIY-IQTISОDIY MЕXANIZMINI TAKОMILLASHTIRISH
Authors: Xolmuradov Raxmatilla
Published: October 2024

Ushbu ilmiy maqolada ahоlining barcha qatlamlari manfaatlarini hisоbga оlgan hоlda bоzоr iqtisоdiyоti tamоyillariga muvоfiq uy-jоy siyоsati va uy-jоy munоsabatlarini shakllantirish, uy-jоy kоmmunal xо‘jaligini islоh qilishda asоsiy vazifa islоhоt mеxanizmini tartibga sоlishda davlat ishtirоkining shakllari va miqdоrlarini aniqlash, tartibga sоlish shakllari bo‘yicha: maqsadli kоmplеks rivоjlanish dasturlari (fеdеral, mintaqaviy, shahar); о‘rta va qisqa muddatli dasturlash; rivоjlanishni rag‘batlantirish yullariga e’tibor qaratilgan. Uy-jоy kоmmunal xо‘jaligini rivоjlantirish dasturlarini bоsqichma-bоsqich amalga оshirish maqsadida, аholining uy-joyga bo‘lgan ehtiyojning oshib borishi, yangidan qurilayotgan uy-joylar, mavjudlari bo‘yicha ta’mirlash ishlarining olib borishda davlat tomonidan berilayotgan imtiyozlar  bo‘yicha takliflar ishlab chiqilgan.
ПАХТА ТЎҚИМАЧИЛИК КЛАСТЕРИДА ИШЛАБ ЧИҚАРИШНИНГ ҚИЙМАТ ЯРАТИШ ЗАНЖИРИНИ ТАКОМИЛЛАШТИРИШ ЙЎНАЛИШЛАРИ
Authors: Қудратова Ирода
Published: October 2024

Мақолада пахта тўқимачилик кластерида қиймат яратиш занжири, қиймат драйверларининг “4Е” тамойилига кўра уйғунлашуви келтирилган. Пахта-тўқимачилик кластерида қиймат драйверларини транспорт, инвестициявий, инфратузилмавий ва хомашё драйверлари мажмуи сифатида тизимли тадқиқ қилиш мақсадга мувофиқлиги асослаб берилган.
HUDUDIY SANOAT MAHSULOTLARI EKSPORT SALOHIYATINI OSHIRISH: XORAZM VILOYATI MISOLIDA
Authors: Raximov Alisher , Xotamov Ibodullo
Published: October 2024

Maqolada Xorazm viloyati eksport strukturasini oʻzgarish dinamikasi hamda eksportni oshirish boʻyicha viloyat salohiyati, Oʻzbekiston Respublikasi eksportida oʻrni tahlil qilingan. Shuningdek, viloyat eksportini 10 yillik dinamikasi tahlil qilinib, eksport oʻsishiga taʼsir qilgan mahsulotlar taʼsiri koʻrib chiqilgan. Tahlil natijalaridan kelib chiqqan holda viloyat eksporti hajmini, salohiyatini oshirish imkoniyatlari, yoʻnalishlari koʻrsatib oʻtilgan.
MAMLAKATGA JALB QILINGAN XORIJIY KAPITAL VA INSTITUTSIONAL TIZIM O‘RTASIDAGI MUNOSABATNI EKONOMETRIK MODELLARLASHTIRISH
Authors: Saydullayev Azamat
Published: October 2024

Ushbu maqolada ekonometrik modellar yordamida xorijiy kapital oqimi va mamlakat institutsional tizimi o‘rtasidagi munosabatlar tahlili ko‘rib chiqiladi. Tadqiqot chet el kapitali mamlakatning iqtisodiy rivojlanishi va boshqaruv dinamikasini tushunish uchun muhim bo‘lgan institutsional asosga qanday ta`sir qilishini tushunishga qaratilgan. Ekonometrik tahlil orqali tadqiqot mamlakatga jalb qilingan xorijiy kapital va uning institutsional tizimining turli o‘lchovlari, jumladan, tartibga solish sifati, qonun ustuvorligi, hukumat samaradorligi va korruptsiyani nazorat qilish o‘rtasidagi sababiy bog‘liqlikni o‘rganadi. Panel ma`lumotlarni tahlil qilish, vaqt seriyali modellashtirish va strukturaviy tenglamalarni modellashtirish kabi ekonometrik usullardan foydalangan holda tadqiqot xorijiy kapital institutsional rivojlanishga ta`sir ko‘rsatadigan muhim mexanizmlarni ochib berishga qaratilgan.
МИЛЛИЙ ИҚТИСОДИЁТДА ХИЗМАТЛАР СОҲАСИ РОЛИНИНГ ИҚТИСОДИЙ-СТАТИСТИК ТАҲЛИЛ ҚИЛИШ
Authors: Хусанов Муроджон
Published: October 2024

Мазкур мақолада миллий иқтисодиётда хизматлар соҳаси ролининг иқтисодий-статистик таҳлил қилиш, хизматлар соҳасида ҳажм яратувчи ҳамда мазкур соҳада фаолият юритувчи субъектларнинг таҳлили, Ўзбекистонда хизматлар соҳасининг ривожланиб бориш динамикаси таҳлили кўрсатиб берилган. Олиб борилган таҳлиллар, биргина мисол тариқасида Ўзбекистонда хусусий тиббиёт муассасалари сонинг кундан кунга ортиб бораётганини кўрсатмоқда. Бу эса, ўз навбатида, тиббиёт соҳасида соғлом рақобатни юзага келтириб, аҳолига кўрсатилаётган тиббий хизмат сифатини ошириш ва уларнинг нархини пасайтириш имконини бермоқда. Юқоридагилар бутун жаҳонда юз бераётган тенденциялар, айниқса Ковид-19 пандемиясидан кейин жадал ривожланаётган хизматларнинг янги турлари Ўзбекистон бозорига ҳам кириб келаётгани, бу эса, иқтисодий ривожланиш стратегиялари, мақсадли дастурлар ва хизматлар соҳасини ривожлантириш борасидаги қарорлар қабул қилишда алоҳида эътибор қаратишни тақозо этади.
OZIQ-OVQAT SANOATI KORXONALARI INVESTITSION SALOHIYATINI BAHOLASHNING USLUBIY ASOSLARI
Authors: Xаmrаеv Nоdirbеk
Published: October 2024

Maqolada asosiy iqtisodiy kategoriyalardan biri - investitsiya salohiyati ko'rib chiqilgan. Jumladan, oziq-ovqat sanoati korxonalari tushunchasining mohiyati ochib berilgan hamda investitsiya faoliyatini amalga oshiruvchi oziq-ovqat sanoati korxonalari nuqtai nazaridan har tomonlama ko‘rib chiqish zarurligi ko‘rsatilgan. Oziq-ovqat sanoati korxonalarining investitsiya salohiyatiga ta'rif berilgan va uni tashkil  etuvchi omillar shakllantirilgan.
UY XO‘JALIKLARI VA OILALARNING UY-JOY BILAN TA’MINLANGANLIK DARAJASI VA IPOTEKA KREDITI TAHLILI
Authors: Berdaliyeva Muxabbatxon
Published: October 2024

Maqolada uy-joy bozori dinamikasini belgilovchi asosiy omillar, xususan uy-joyga bo‘lgan talab va taklif, uy-joy va ijara narxlari, shuningdek aholining uy-joyga bo‘lgan yuqori talabini qondirishda davlat tomonidan qo‘llab-quvvatlash tizimi kabi masalalar o‘rganildi. Shu bilan birga, hududlar kesimida aholini uy-joy bilan ta’minlashning dolzarb masalalari, uy xo‘jaliklari va qurilish kompaniyalari orasida o‘tkazilgan so‘rov natijalari ham maqolada o‘z aksini topgan. O‘zbekiston ko‘chmas mulk va ipoteka bozori tahlili nafaqat hozirgi ko‘chmas mulk bozorining holatini o‘rganishga, balki kelajakdagi strategik rejalashtirish va qarorlar qabul qilish jarayonlarida foydalanish uchun ham asosiy ma’lumotlar va tushunchalar keltirilgan.
MINTAQADA UY-JOY SIYOSATINING MOHIYATI
Authors: Yuldosheva Shahribonu
Published: October 2024

Jahonda globallashuv va integratsiya jarayonining rivojlanishi, raqobatning keskinlashuvi, xizmatlar ko‘rsatish darajasining samaradorligini oshirish hamda sifat ko‘rsatkichlarining ustuvorligini ta’minlash  bugungi kunda dolzarb vazifalardan hisoblanmoqda. Uy-joy kommunal xizmat ko‘rsatish tizimi aholi turmush darajasi va sifatini ta’minlashning  eng muhim tarkibiy qismi bo‘lib, xizmatlar  samaradorligini oshirish sohaning asosiy maqsadlaridan biridir. Mazkur sohalar rivojlanishiga bo‘lgan ob’ektiv zarurat aholi turmush darajasi sifatini yuksaltirish barobarida ish bilan bandlik darajasining ortishiga ham ijobiy ta’sir ko‘rsatadi. Uy-joy kommunal servis xizmati sohasi rivojlanishining ilmiy-metodologik jihatlari ko‘plab xorijlik olimlar tomonidan tadqiq qilingan. Ushbu maqolada ilmiy abstraksiyalash, tahlil va sintez, induksiya va deduksiya usullaridan foydalanilgan. Shuningdek, uy-joy siyosati, uy-joy kommunal xo‘jaliklarining faoliyati, xizmatlar turlari, kommunal xo‘jaliklarning samaradorligini oshirish bo‘yicha olib borilayotgan islohotlar hamda ularning asosiy yo‘nalishlari to‘g‘risidagi fikrlar bayon etilgan.
Pharmacy Undergraduates’ Epistemic Cognition and Medication Beliefs as Predictors of Conceptual Learning and Academic Progress
Authors: Sodervik Ilona , Hanski Leena , Laakkonen Eero , Katajavuori Nina
Published: October 2024

The importance of studies showing the impact of students' epistemic beliefs on their conceptual learning and academic progress is increasing. This study investigated pharmacy students’ domain-specific epistemic cognition and topic-specific beliefs related to their level of conceptual prior knowledge, learning and study progress during the first academic year. Data were collected from 125 students using a pre-test/post-test design with a multiple-choice questionnaire, an open-ended case task and a measure of domain-specific epistemic cognition and topic-specific beliefs concerning medication. The results showed that students’ prior knowledge predicted their academic performance and more sophisticated epistemic cognition was related to better conceptual understanding, faster study progress, and fewer anti-medication beliefs. Anti-medication beliefs hindered participants’ success in the case task and were related to weaker study progress. Our study shows that epistemic cognition and topic-specific beliefs play a role in students’ performance, learning, and study progress
Exploration of Blended Online and Offline Teaching Based on "Medicinal Basic Chemistry"
Authors: Cui Lisha , Ren Xiaoli , Li Xixi , Sui Chaoya
Published: October 2024

Medicinal Basic Chemistry" integrates the basic theories and knowledge of inorganic chemistry and organic chemistry. However, our school's students have different foundations when entering the school. In the blended teaching of online and offline courses, students can choose whether to watch or not, teach according to their aptitude, and meet the personalized growth needs of students. Through mutual assistance discussions on self-prepared topics, independent thinking is first completed, and then group discussions are optimized, students can be urged to actively learn and judge whether others' ideas are reasonable. Suggestions for modification are proposed, and others are taught. By using good to lead and medium to lead, students can achieve overall improvement at the class level. This method is also applicable in practical training courses.
The Role of Data Analytics and Sustainable Circular Economy in Developing Countries
Authors:   Institute of Analytics and International Institute of Business Analysis, Nwobodo Luther Kington
Published: October 2024

In the twenty-first century, data analytics has become a vital tool in decision-making. Modern companies and organisations create enormous volumes of data, which need for sophisticated ways to analyse. Statistics help companies make data-driven decisions by organising, summarizing, and interpreting data. 21st-century enterprises, organisations, and people generate more data than ever. Due to rapid technological advancement and growing data, companies must make data-driven choices. As such, the place of data analytics is the era of digital economy cannot be overemphasize. This paper essentially review these roles in achieving sustainable circular economy in developing countries. The study was based solely on secondary data elicited from the review of previous studies on the subject being investigated. The examined the concepts and benefits of circular economy, the challenges in implementing circular economy in developing countries, as well as the concept, impact and role of data analytical impact on achieving sustainable circular economy. The overall findings from this study indicates that indeed, data analytics play important role in achieving sustainable circular economy in developing countries and thus recommends the system theory approach to circular economy where all parts are connected in somewhere to enhance effectiveness and reduce cost. Such connection can only be efficient through data analytics.
Structures of Forest Stands in Monospecific Reforestations Based on Tectona grandis Lf. (Verbenaceae) in the Sangoué Classified Forest in Côte d’Ivoire
Authors:   Jean Lorougnon Guédé University, Daloa, Côte d’Ivoire, Anthelme GNAGBO , Mathieu EGNANKOU Wadja , Bernadin DRO , Trésor GODÉ Guy , Yves ADOU YAO Constant ,   Félix Houphouet-Boigny University, Abidjan, Côte d’Ivoire
Published: October 2024

Teak-based reforestation poses the challenge of sustainable development in terms of meeting economic, social and environmental needs. In order to meet the needs of populations for timber and contain anthropogenic pressures on flora, reforestation based on Tectona grandis is initiated in the Sangoué Classified Forest. Therefore, a diagnostic study is therefore essential to assess the effects of this practice on the environment. This study assessed the consequences of planting Tectona grandis on the conservation and restoration of the Sangoué classified forest. For this, the structural and floristic characteristics of teak stands at different stages of evolution were compared. The results showed that young plots have more plant species, are more diverse and more evenly distributed. Older plots have the highest densities and basal areas of stems, with an inverted J-shaped distribution. Young plots have the lowest densities and basal areas, as well as a more regular horizontal structure. The woody species introduced into reforestation are Tectona grandis, Gmelina arborea and Cedrela odorata. In the 33-year-old block, the total basal area value is 18.07 m² per hectare, then 13.72 m² per hectare in the 30-year-old block. As for the 25- and 28-year-old blocks, the basal area values per hectare are 12.61 m2 and 9.39 m2 respectively. Young plots promote natural regeneration and floristic diversity, while older plots present low floristic diversity with reduced structural balance. Introduced species have benefited more from teak planting than native ones. Teak planting may lead to profit, but it presents challenges for biodiversity. The impact of teak planting on the Sangoué classified forest differs depending on the stage of evolution of the stands. Therefore, it has advantages and disadvantages for forest restoration and conservation. The teak plantation needs to be adjusted to forest management.