bluuebunny/crossref_metadata_2025 huggingface dataset:
Safety and Efficacy of Polymer-Free Drug-Eluting Stents
Authors: Chiarito Mauro , Sardella Gennaro , Colombo Antonio , Briguori Carlo , Testa Luca , Bedogni Francesco , Fabbiocchi Franco , Paggi Anita , Palloshi Altin , Tamburino Corrado , Margonato Alberto , Pivato Carlo Andrea , Baber Usman , Calcagno Simone , Giordano Arturo , Godino Cosmo , Stefanini Giulio G. ,   on behalf of the RUDI-Free and ASTUTE Investigators
Published: February 2019

Background:

Polymer-free drug-eluting stents are based on different technologies for drug binding and release without the use of polymer coatings. It is unknown whether different polymer-free drug-eluting stents are comparable in terms of safety and efficacy profiles.

Methods and Results:

Polymer-free BioFreedom biolimus-eluting stents (BES) and polymer-free Cre8 amphilimus-eluting stents (AES) were investigated in 2 recent multicenter registries including 2320 all-comer patients undergoing percutaneous coronary interventions at 22 Italian centers. Using propensity score matching, safety and efficacy outcomes were compared among 1280 patients (640 matched pairs) treated with BioFreedom BES or Cre8 AES. The primary end point was target lesion failure—a composite of cardiac death, target vessel myocardial infarction, and target lesion revascularization (TLR). At 1 year, target lesion failure occurred in 4.0% of BES and 4.2% of AES-treated patients (hazard ratio [HR] 0.98, 95% CI, 0.57–1.70). Risks of cardiac death (2.0% versus 2.1%; HR, 1.03; 95% CI, 0.47–2.26), target vessel myocardial infarction (0.8% versus 0.3%; HR, 1.89; 95% CI, 0.50–6.80), TLR (1.5% versus 2.2%; HR, 0.74; 95% CI, 0.34–1.62), and definite/probable stent thrombosis (0.9% versus 0.8%; HR, 1.17; 95% CI, 0.36–3.81) were comparable in patients treated with BioFreedom BES and Cre8 AES. A differential treatment effect by diabetes mellitus status was observed, indicating a benefit of AES in patients with diabetes mellitus (
P
interaction=0.003).

Conclusions:

The present study shows that BioFreedom BES and Cre8 AES have favorable and comparable safety and efficacy profiles in all-comer patients undergoing percutaneous coronary intervention. Further evaluation in large-scale, randomized trials are necessary to confirm our findings.
Relationship Between Endothelial Function and the Eliciting Shear Stress Stimulus in Women: Changes Across the Lifespan Differ to Men
Authors: Holder Sophie M. , Brislane Áine , Dawson Ellen A. , Hopkins Nicola D. , Hopman Maria T. E. , Cable N. Timothy , Jones Helen , Schreuder Tim H. A. , Sprung Victoria S. , Naylor Louise , Maiorana Andrew , Thompson Andrew , Thijssen Dick H. J. , Green Daniel J.
Published: February 2019

Background

Premenopausal women have a lower incidence of cardiovascular disease, which may partly be due to a protective effect of estrogen on endothelial function. Animal studies suggest that estrogen may also improve the relationship between shear rate (
SR
) and endothelial function. We aimed to explore the relationship between endothelial function (ie, flow‐mediated dilation [
FMD
]) and
SR
(ie,
SR
area under the curve [
SRAUC
]) in women
versus
men, and between pre‐
versus
postmenopausal women.

Methods and Results

Brachial artery
FMD
and
SRAUC
were measured in accordance with expert‐consensus guidelines in 932 healthy participants who were stratified into young adults (18‐40 years, 389 men, 144 women) and older adults (>40 years, 260 men, 139 women). Second, we compared premenopausal (n=173) and postmenopausal women (n=110). There was evidence of a weak correlation between
SRAUC
and
FMD
in all groups but older men, although there was variation in strength of outcomes. Further exploration using interaction terms (age‐sex×
SRAUC
) in linear regression revealed differential relationships with
FMD
(young women
versus
young men [β=−5.8
−4
,
P
=0.017] and older women [β=−5.9
−4
,
P
=0.049]). The correlation between
SRAUC
and
FMD
in premenopausal women (
r
2
=0.097) was not statistically different from that in postmenopausal women (
r
2
=0.025; Fisher
P
=0.30). Subgroup analysis using stringent inclusion criteria for health markers (n=505) confirmed a stronger
FMD
‐
SRAUC
correlation in young women compared with young men and older women.

Conclusions

Evidence for a stronger relationship between endothelial function and the eliciting
SR
stimulus is present in young women compared with men. Estrogen may contribute to this finding, but larger healthy cohorts are required for conclusive outcomes.
Impact of Diabetes Mellitus on Ventricular Structure, Arterial Stiffness, and Pulsatile Hemodynamics in Heart Failure With Preserved Ejection Fraction
Authors: Chirinos Julio A. , Bhattacharya Priyanka , Kumar Anupam , Proto Elizabeth , Konda Prasad , Segers Patrick , Akers Scott R. , Townsend Raymond R. , Zamani Payman
Published: February 2019

Background

Heterogeneity in the underlying processes that contribute to heart failure with preserved ejection fraction (
HF
p
EF
) is increasingly recognized. Diabetes mellitus is a frequent comorbidity in
HF
p
EF
, but its impact on left ventricular and arterial structure and function in
HF
p
EF
is unknown.

Methods and Results

We assessed the impact of diabetes mellitus on left ventricular cellular and interstitial hypertrophy (assessed with cardiac magnetic resonance imaging, including T1 mapping pregadolinium and postgadolinium administration), arterial stiffness (assessed with arterial tonometry), and pulsatile arterial hemodynamics (assessed with in‐office pressure‐flow analyses and 24‐hour ambulatory monitoring) among 53 subjects with
HF
p
EF
(32 diabetic and 21 nondiabetic subjects). Despite few differences in clinical characteristics, diabetic subjects with HFpEF exhibited a markedly greater left ventricular mass index (78.1 [95%
CI
, 70.4–85.9] g versus 63.6 [95%
CI
, 55.8–71.3] g;
P
=0.0093) and indexed extracellular volume (23.6 [95%
CI
, 21.2–26.1] mL/m
2
versus 16.2 [95%
CI
, 13.1–19.4] mL/m
2
;
P
=0.0008). Pronounced aortic stiffening was also observed in the diabetic group (carotid‐femoral pulse wave velocity, 11.86 [95%
CI
, 10.4–13.1] m/s versus 8.8 [95%
CI
, 7.5–10.1] m/s;
P
=0.0027), with an adverse pulsatile hemodynamic profile characterized by increased oscillatory power (315 [95%
CI
, 258–373] mW versus 190 [95%
CI
, 144–236] mW;
P
=0.0007), aortic characteristic impedance (0.154 [95%
CI
, 0.124–0.183] mm Hg/mL per second versus 0.096 [95%
CI
, 0.072–0.121] mm Hg/mL per second;
P
=0.0024), and forward (59.5 [95%
CI
, 52.8–66.1] mm Hg versus 40.1 [95%
CI
, 31.6–48.6] mm Hg;
P
=0.0010) and backward (19.6 [95%
CI
, 16.2–22.9] mm Hg versus 14.1 [95%
CI
, 10.9–17.3] mm Hg;
P
=0.0169) wave amplitude. Abnormal pulsatile hemodynamics were also evident in 24‐hour ambulatory monitoring, despite the absence of significant differences in 24‐hour systolic blood pressure between the groups.

Conclusions

Diabetes mellitus is a key determinant of left ventricular remodeling, arterial stiffness, adverse pulsatile hemodynamics, and ventricular‐arterial interactions in
HF
p
EF
.

Clinical Trial Registration

URL
:
https://www.clinicaltrials.gov
. Unique identifier:
NCT
01516346.
Biologically Realistic Mean-Field Models of Conductance-Based Networks of Spiking Neurons with Adaptation
Authors: di Volo Matteo , Romagnoni Alberto , Capone Cristiano , Destexhe Alain
Published: February 2019

Accurate population models are needed to build very large-scale neural models, but their derivation is difficult for realistic networks of neurons, in particular when nonlinear properties are involved, such as conductance-based interactions and spike-frequency adaptation. Here, we consider such models based on networks of adaptive exponential integrate-and-fire excitatory and inhibitory neurons. Using a master equation formalism, we derive a mean-field model of such networks and compare it to the full network dynamics. The mean-field model is capable of correctly predicting the average spontaneous activity levels in asynchronous irregular regimes similar to in vivo activity. It also captures the transient temporal response of the network to complex external inputs. Finally, the mean-field model is also able to quantitatively describe regimes where high- and low-activity states alternate (up-down state dynamics), leading to slow oscillations. We conclude that such mean-field models are biologically realistic in the sense that they can capture both spontaneous and evoked activity, and they naturally appear as candidates to build very large-scale models involving multiple brain areas.
Using Weather Pattern Recognition to Classify and Predict Summertime Heavy Rainfall Occurrence over the Upper Nan River Basin, Northwestern Thailand
Authors: Nguyen-Le Dzung , Yamada Tomohito J.
Published: February 2019

In this study, self-organizing maps in combination with K-means clustering are used to objectively classify the anomalous weather patterns (WPs) associated with the summertime [May–June (MJ) and July–August–September (JAS)] heavy rainfall days during 1979–2007 over the Upper Nan River basin, northwestern Thailand. The results show that in MJ, intensive rains are mainly brought by the remarkable enhancement of the westerly summer monsoon. Meanwhile, westward-propagating tropical disturbances including tropical cyclones are the primary factors that reproduce heavy rainfall over the Upper Nan in JAS. These results also suggest that the occurrence time of local heavy rainfall is strongly related to the seasonal transition of the summer monsoon over the Indochina Peninsula. The classification results are then implemented with the perfect prognosis and analog method to predict the occurrence (yes/no) of heavy rainfall days over the studied basin in summer 2008–17 using prognostic WPs from the operational Japan Meteorological Agency Global Spectral Model (GSM). In general, the forecast skill of this approach up to 3-day lead times is significantly improved, in which the method not only outperforms GSM with the same forecast ranges, but also its 3-day forecast is better than the 1–2-day forecasts from GSM. However, the false alarms ratio is still high, particularly in JAS. Nevertheless, it is expected that the new approach will provide warning and useful guidance for decision-making by forecasters or end-users engaging in water management and disaster prevention activities.
Vibration of an axially moving jet in a dry spinning process
Authors: Zhang Li , Yang Zhanping , Feng Xiaomin , Cao Jianhua , Yu Tao , Tian Dan , Yao Shaowen
Published: February 2019

During the dry spinning process for fabrication of cellulose acetate fibers, the moving jet is approximated as a string, and its vibration equation is established. The vibration frequency affects greatly the fiber’s mechanical property and crimp frequency. An experiment was carried out to verify the theoretical prediction.
High‐risk pregnancy in a patient with pulmonary arterial hypertension due to congenital heart disease (PAH‐CHD) with temporary shunt inversion and deoxygenation
Authors: Hohmann Christopher , Dumitrescu Daniel , Gerhardt Felix , Kramer Tilmann , Rosenkranz Stephan , Huntgeburth Michael
Published: February 2019

Atrial septal defect (ASD) is one of the most frequent congenital heart diseases (CHD). Up to 10% of adults with an ASD develop pulmonary arterial hypertension (PAH, PAH‐CHD) in their lifetime. Despite improved therapy options, gravidity remains a substantial risk for both maternal and neonatal mortality in PAH‐CHD patients.

In our patient, gravidity remained uncomplicated until week 32, under specific monotherapy with tadalafil, before onset of dyspnea and markedly increase of systolic pulmonary arterial pressure (PAP) was observed in echocardiography. Urgent Caesarian delivery was performed without any complications and a healthy baby was born. However, immediately afterwards, the patient desaturated (SpO2 65%, PaO2 37 mmHg) due to a shunt inversion with now right‐to‐left shunt through the residual ASD. She was admitted to our intensive care unit and specific PH therapy was escalated to a triple combination of tadalafil, ambrisentan, and iloprost. Hereafter, in a slow process of approximately three weeks, the patient's condition improved to baseline.

This rare case of a young woman with high‐risk pregnancy in PAH‐CHD highlights the hemodynamic changes and treatment options during pregnancy in these patients and emphasizes the urgency of a close monitoring at specialized GUCH/PAH centers with experience in managing PAH under these circumstances.
Multiple supporting cell subtypes are capable of spontaneous hair cell regeneration in the neonatal mouse cochlea
Authors: McGovern Melissa M. , Randle Michelle R. , Cuppini Candice L. , Graves Kaley A. , Cox Brandon C.
Published: February 2019

Supporting cells (SCs) are known to spontaneously regenerate hair cells (HCs) in the neonatal mouse cochlea, yet little is known about the relative contribution of distinct SC subtypes which differ in morphology and function. We have previously shown that HC regeneration is linked to Notch signaling, and some SC subtypes, but not others, lose expression of the Notch effector Hes5. Other work has demonstrated that Lgr5-positive SCs have an increased capacity to regenerate HCs; however, several SC subtypes express Lgr5. To further investigate the source for spontaneous HC regeneration, we used three CreER lines to fate-map distinct groups of SCs during regeneration. Fate-mapping either alone or combined with a mitotic tracer showed that pillar and Deiters' cells contributed more regenerated HCs overall. However, when normalized to the total fate-mapped population, pillar, Deiters', inner phalangeal and border cells had equal capacity to regenerate HCs, and all SC subtypes could divide after HC damage. Investigating the mechanisms that allow individual SC subtypes to regenerate HCs and the postnatal changes that occur in each group during maturation could lead to therapies for hearing loss.
Immune challenge-induced oxidative damage may be mitigated by biliverdin
Authors: Baylor Jessica L. , Butler Michael W.
Published: February 2019

An effective immune response results in the elimination of pathogens, but this immunological benefit may be accompanied by increased levels of oxidative damage. However, organisms have evolved mechanisms to mitigate the extent of such oxidative damage, including the production and mobilization of antioxidants. One potential mechanism of mitigating immune-challenge-induced changes in oxidative physiology is increasing biliverdin production. Biliverdin is chemically an antioxidant, but within-tissue correlations between biliverdin concentration and oxidative damage have never been directly examined. To test how biliverdin tissue concentrations are associated with physiological responses to an immune challenge, we exposed northern bobwhite quail (Colinus virginianus) to one of four treatments: an injection of a non-pathogenic antigen, (i.e., either lipopolysaccharide or phytohaemagglutinin), a control injection of phosphate buffered saline, or a sham procedure with no injection. Twenty-four hours later, we quantified oxidative damage and triglyceride concentration in the plasma, and biliverdin concentration in the plasma, liver, and spleen. We found that both types of immune challenge increased oxidative damage relative to both non-injected and sham-injected controls, but treatment had no effects on any other metric. However, across all birds, oxidative damage and biliverdin concentration in the plasma were negatively correlated, which is consistent with a localized antioxidant function of biliverdin. Additionally, we uncovered multiple links between biliverdin concentration, change in mass during the immune challenge, and triglyceride levels, suggesting that pathways associated with biliverdin production may also be associated with aspects of nutrient mobilization. Future experiments that manipulate biliverdin levels or oxidative damage directly could establish a systemic antioxidant function or elucidate important physiological impacts on body mass maintenance and triglyceride storage, mobilization, or transport.
The Effect of Sprint Interval Training on Body Composition of Postmenopausal Women
Authors: BOUTCHER YATI N. , BOUTCHER STEPHEN H. , YOO HYE Y. , MEERKIN JARROD D.
Published: February 2019

Introduction

Menopause is accompanied by body composition changes that include a decrease in lean mass and aerobic fitness and an increase in fat mass. Sprint interval training (SIT) may be able to reverse these changes.

Purpose

To examine the effect of an 8-wk SIT program on body composition and aerobic fitness of overweight postmenopausal women.

Methods

Forty postmenopausal women were randomized into SIT (n = 20) or control (n = 20) groups. The SIT group completed three SIT sessions a week for 8 wk with each session consisting of 20 min of alternating 8-s sprints and 12-s of light pedaling. Total mass, regional lean mass, and fat mass were assessed using dual-energy x-ray absorptiometry. Maximal oxygen uptake (V˙O2max) was predicted using a submaximal test.

Results

Total lean mass was significantly increased from pretest (48.1 ± 5.81 kg) to posttest (48.8 ± 5.96 kg) and fat mass was significantly reduced (pre, 29.5 ± 7.29 kg; post, 29.1 ± 7.61 kg) for the SIT group. Lean mass was mostly increased in the trunk (pre, 24.4 ± 2.79 kg; post, 24.8 ± 2.93 kg) and legs (pre, 15.6 ± 2.31 kg; post, 15.9 ± 2.34 kg). V˙O2max was significantly increased from pretest (21.7 ± 4.89 mL⋅kg−1⋅min−1) to posttest (24.4 ± 5.96 mL⋅kg−1⋅min−1) for the SIT group only.

Conclusions

The SIT intervention increased total lean mass, decreased fat mass, and increased aerobic fitness of postmenopausal women after only 8 h of actual exercise over 8 wk.
All-Russian Academic Olympics As a Systematic Procedure for Assessing the Quality of General Education and the Development of Individual Intellectual Abilities of Students in the Russian Federation
Authors: Абатурова Валентина , Abaturova Valentina , Цветкова М. , Tsvetkova Marina
Published: February 2019

All-Russian Academic Olympics is held for more than 30 years and represents the most massive intellectual competitive event for school students in the country covering all the regions of the Russian Federation, that allows to consider the annual results of the 24 school subjects as a systematic procedure for the evaluation of the quality of school education and development of gifted students in Russia
Modern Information Technology in Education
Authors: Бирюкова М. , Biryukova M. , Невежин Виктор , Nevezhin Victor
Published: February 2019

The modern period of development of society is subject to a strong infl uence on it of information technologies, which, in turn, penetrate into all spheres of human life, forming a global information space. An integral and important part of such processes is the informatization of education. The introduction of technology makes it possible to qualitatively change the methods and forms of the learning process, making it more comfortable and aff ordable. In our country, one of the top priorities has always been to get quality education and useful skills. However, for several reasons, there are certain obstacles to the full implementation of technology in the learning process. The relevance of the chosen topic is due to the transition of education to an innovative development path. The article discusses the experience of introducing information technology in the educational process in order to improve and move to a new level. A comparative analysis of existing approaches and achievements using information technologies is carried out. Attention is paid to Russian educational online projects and the costs of their implementation.
Synthesis, characterization and in vitro biological screening of 4-hydroxy naphthalen-1-yl, naphtho[1,2-b]furan, benzo[h]chromene and 5,6-dihydropyridazine derivatives containing sulfonamide moiety
Authors: El-Gaby Mohamed S. A. , Hassan Mohamed I. , Hussein Modather F. , Ali Ahmed M. , Elaasser Mahmoud M. , Faraghally Faraghally A.
Published: February 2019

In this study, a series of 4-((4-hydroxynaphthalen-1-yl)diazenyl)benzenesulfonamides have been prepared by subsequent diazotization of sulfonamide derivatives and coupling with 1-naphthol in alkaline medium. Cyclization of 4-((4-hydroxynaphthalen-1-yl)diazenyl)benzenesulfonamides with cinnamic acid in the presence of a basic catalyst afforded the novel naphtho[1,2-b]furans. Also, 4-((4-hydroxynaphthalen-1-yl)diazenyl)benzenesulfonamides can be cyclized with α‐cyanocinnamonitriles to afford 2-amino-3-cyano-4-phenyl-4H-benzo[h]chromenes. 4-(4-amino-3,5- dicyano-6-iminopyridazin-1(6H)-yl)benzenesulfonamides were obtained at room temperature by treatment of 2-amino-1,1,3-tricyanopropene with a diazonium salt of sulfonamide derivatives. The structures of newly synthesized compounds were confirmed by analytical data and spectroscopic techniques. The antimicrobial activity of the obtained compounds was assessed in vitro by qualitative and quantitative (minimum inhibitory concentration) (MIC) assays.
Hizkuntza-ospearen eta eragin lektalaren zirurikak Ipar Euskal Herriko jende, mintzo eta idazkietan / Language-prestige and lectal influence in the people, speech and writings of the Northern Basque Country
Authors: Camino Iñaki
Published: February 2019

Euskal jendeen etengabeko giza-harremanaren bitartez, luzaz kurritu dute hizkuntza-eraginek eta aldaerek Lapurdi eta Baxenabarreko euskal mintzoen artean, jendeen bitartez ahozkoan eta testu eta liburuen bidez idatzizkoan. Hizkuntza-berrikuntzei so eginik eta ikuspegi filologiko-dialektologikoan bermaturik, eragin horren berri dakart eta ezaugarri horietarik batzuk aurkezten ditut, nabarmenak eta paradigmatikoak diruditen ale batzuk. Lapurdiko idatzizko aldaera batzuen agerraldiei ikusaldi bat egin diet eta prestigioaren aferaz herriaren ahotik era naturalenean bildu emaitza batzuk dakartzat. Lapurdiko euskara bezala Baxenabarreko euskara, hiztun arruntek bi izen horiek ente errealtzat jotzen badituzte ere, aktualismoak iragana lausotu ez diezagun eta hipotesiak libre jaio daitezen, ikertzaileak nomenklatura horren arriskua saihestera jo behar du baitezpada, administrazioa eta hizkuntza ez baitoaz batera. Ikertzailearen eginkizuna hizkuntza-ezaugarrien espazioa eta erabilera-garaia zehazterakoan funski eraunstea da, izan ere, idazkietan ageri diren hizkuntza-tasun batzuk noiztik noiz arte eta zein eskualdetan —zehazki nondik noraino— erabiltzen ziren xuxen ez jakiteak hutsune eta ilunguneak eragin ditzake hipotesietan, ezagutzaren eta azterketa egokiaren kaltegarri.
Bilingüismo y realidad sociolingüística de la lengua inga en Colombia / Bilingualism and Sociolinguistic Reality in the Inga Language of Colombia
Authors: Etxebarria Maitena
Published: February 2019

The main goal of the research presented here is to study the Inga speech community. Inga is a Quechuan language, and its community is spread around the south of Colombia; the study tackles the features of language contact, Spanish/Inga or amongst any other languages known and used by the members of the community. We shall pay special attention to those communities around Sibundoy Valley (Putumayo), Atante (Nariño), Bota Caucana (Cauca), as well as to those already settled in the large Colombian urban areas such as Bogotá and Cali. Our main goal is to render an adequate characterization of this indigenous community: its territorial situation, its sociolinguistic characteristics, the degree and type of bilingualism amongst its members, the survival of the community members and of the language itself, the use and distribution of the language across communicative fields, especially in a context of diglosia, multilingualism and multiculturality typical of and intrinsic to Colombia, and the study of language awareness and sociolinguistic attitudes of this community.
Izen ttipiak euskaraz. "Addenda, confirmanda et corrigenda" / Basque hypocoristic. "Addenda, confirmanda et corrigenda"
Authors: Salaberri Zaratiegi Patxi
Published: February 2019

Hemen 2009an argia ikusi zuen Izen Ttipiak Euskaraz liburuan bildutako hipokoristikoen gainean mintzo gara. Sarreraren ondotik, aurrena orain arte ezagutzen genituen izen ttipiak berresten saiatzen gara, haien denbora-iraupena eta hedadura hobeki zehazten, hona lekuko gehiago ekarriz, aipatu liburuan erraten zirenak baieztatu nahian. Hau da, izan ere, gure artikuluaren funtsa eta mamia. Gero, bigarren puntuan, zuzentzekoetan, 2009ko obran oker zegoen izen ttipi batez mintzo gara, laburki, eta ondoren hipokoristiko pare batek beste interpretazio bat ez ote dezakeen izan iradokitzen dugu, liburuan emandakoaz gainera. Bukatzeko, ondorioak ateratzen ditugu, besteak beste zenbait hipokoristikok guneka agertzeko joera dutela diogu, eta izen konposatuetan ere ager daitezkeela, denbora batetik aitzina.
Onomastikaren ekarpena populatzearen berreraiketan Euskal Herrian / The Contribution of Onomastics to the Reconstruction of Settlement in the Basque Country
Authors: Zaldua Etxabe Luis Mari
Published: February 2019

Joakin Gorrotxategiren ekarpena eskertzeko saio honen asmoa Antzinateko antroponimoak eta latinetiko atzizkiak oinarritzat dituzten saroi-izenen banaketa, zentzua eta etorkia aztertzea da, Euskal Herriko populatzearen berreraiketan lagun dezakeelakoan aztertu ere. Horretarako, abiapuntua Eibarko irakaslearen 1993ko artikulu bat da: «La aportación de la lingüística a la reconstrucción del poblamiento en el País Vasco» argitalpena.
Ketaminaren eragin antidepresiboak. Ekintza mekanismo berriak farmako antidepresiboen bilaketarako
Authors: Borrega Leire , Saumell Miquel , Isasti Amaia , Aretxabala Xabier , Gonzalez-Burguera Imanol , López de Jesús Maider , García del Caño Gontzal , Sallés Joan , Barrondo Sergio
Published: February 2019

Beste Medikuntza-arloetan ez bezala, Psikiatrian gaixotasun psikiatrikoei buruzko hipotesi etiologikoak ebidentzia farmakologikoetan oinarritzen dira. Horrela, 1950eko hamarkadan depresioaren kontrako farmakoak garatzen hasi ziren, behin ikusita zer-nolako eraginak zituzten tuberkulosiaren kontrako farmako batzuek. Lehenengo antidepresiboek neuro-transmisio monoaminergikoa bultzatzen zutenez, hipotesi monoaminergikoa sortu zen, eta depresioari buruzko ikerkuntzak serotoninaren, noradrenalinaren eta dopaminaren (monoaminen) gutxiagotzea hartu zuen oinarri. Orduz geroztik hipotesi monoaminergikoak, eta bere bariazioek, farmako antidepresiboen garapena baldintzatu dute. Hala ere, azkeneko urteetan egindako ikerketek erakutsi dute estresak eta depresioak neuronen atrofia eta galera eragiten dutela, eta horrekin batera kortex eta sistema linbikoaren bolumena murrizten dela. Ebidentzia berri hauen arabera, depresioa ez litzateke izango garuneko gune zehatz bateko asaldura hutsa, baizik eta gogo aldartea, kognizioa eta oroimenak kontrolatzen dituzten zirkuitu neuronalen asaldura. Depresioari buruzko azkeneko ikerketa preklinikoek eta klinikoek agerian jarri dute ketaminak (anestesiko disoziatiboa) eragin antidepresibo harrigarriak dituela, azkarrak eta iraunkorrak. Oinarrizko ikerketek ketaminak sinapsi konexioak oso azkar handitzen dituela frogatu dute, depresioan antzemandako neurona-atrofia leheneratzen dutela. Ebidentzia hauek farmako antidepresibo berrien bilaketa berpiztu dute, eta hainbat mekanismo berri proposatu dira helburu horretarako.
Pobrezia Energetikoa Espainian 2008an, 2011n eta 2014an
Authors: Aristondo Oihana , Onaindia Eneritz , Barreras Ariane
Published: February 2019

Lan honetan, Espainiako pobrezia energetikoa aztertu da 2008., 2011. eta 2014. urteetarako. Azterketa hau hiru aldagaitan oinarritu da: etxebizitzak tenperatura egokia mantentzeko ahalmenik duenez, elektrizitate-, ur- edo/eta gas-fakturak ordaintzeko orduan atzerapenik duen eta etxebizitzaren egoera egokia denetz (hezetasunik, itoginik edo leiho puskatuik eza). Lehenengoz, estatu-mailako etxebizitzen pobrezia energetikoa aztertu da. Ondoren, etxebizitzen hiru sailkapen erabili dira etxebizitza kaltetuenak identifikatzeko asmoz. Erabilitako sailkapenak hauek dira: urbanizazio-maila, etxebizitzetako kide desberdinak eta etxebizitzen errenta totala. Azterketa honen ondorioz, jakin dugu pobrezia energetikoak 2008tik 2014ra okerrera egin duela; zehazki, pobrezia energetiko handiena duten taldeak urbanizazio-maila baxukoak, umeak dituzten etxebizitzak eta errenta baxukoak direla.
In vitro Assessment of the Biofield Treated Test Item on Cardiac Function Using Rat Cardiomyocytes Cell Line (H9c2) via Multiparametric Analysis
Authors: Trivedi Mahendra Kumar , Jana Snehasis
Published: February 2019

Introduction
Heart disorders are the major concern of population health worldwide. According to WHO estimates 2018, 17.9 million peoples were died due to cardiovascular disorders.

Aim
The aim of this study was to investigate the cardioprotective activity of Biofield Energy Treated test item, Dulbecco's Modified Eagle Medium (DMEM) using rat cardiomyocytes (H9c2).

Methods
The test item (DMEM) was divided into three parts, first part received one-time Biofield Energy Treatment by a renowned Biofield Energy Healer, Mahendra Kumar Trivedi and was labeled as the one-time Biofield Energy Treated (BT-I) DMEM, while second part received the two-times Biofield Energy Treatment and is denoted as BT-II DMEM. The third part did not receive any treatment and defined as the untreated DMEM group.

Results
Cell viability of the test samples by 3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide (MTT) assay showed 89.03% and 98.49% in the BT-I and BT-II groups, respectively suggested a nontoxic and safe in nature of the tested test item. The BT-I group showed 16.01% restoration of cell viability. The level of lactate dehydrogenase (LDH) was significantly inhibited by 50.37% and 49.35% in the BT-I and BT-II groups, respectively compared to the untreated DMEM group. Moreover, percent protection of creatine kinase-myocardial band (CK-MB) by 49.48% and 59.79% in the BT-I and BT-II groups, respectively, compared to the untreated DMEM group. Reactive oxygen species (ROS) level in terms of mean fluorescence unit (FU) was reduced by 6.64% in the BT-I group than untreated DMEM. Besides, BT-I and BT-II groups significantly increased the level of % apoptotic cells by 63.16% and 97.37% (p≤0.05), respectively than untreated DMEM.

Conclusion
Allover, results envisaged that Biofield Treatment significantly improved different cardiac parameters. Thus, Biofield Energy Treatment (The Trivedi Effect®) could be utilized as a cardio-protectant against several cardiac disorders such as coronary artery disease, heart attack, arrhythmias, heart failure, congenital heart disease, cardiomyopathy, etc.
Development of Learning Module Social Sciences Based Local Wisdom
Authors: Awaludin Dede Firman , Siswono Eko , Japar M
Published: February 2019

This study aims to develop a Social Science-based module of learning based on local wisdom in Elementary School. This research uses research and development method (research and development). The research procedure uses a Borg and Gall model
that has ten stages, namely: (1) the study of knowing; (2) planning; (3) product development; (4) initial field trials; (5) revision of initial field trial results; (6) field trials; (7) improvement of product of field trial result (8) test of field
implementation; (9) refinement of the final product; (10) deployment and usage. Instrument in this research using questionnaire to know the feasibility of the product in terms of expert validation and field trials and the next instrument using the
test. Evaluation is done by three stages, the first stage of expert judgment which is done by the product expert and the material of Social Sciences. The second stage is done to evaluate small group with fifteen students. The test results state that
the Social Science learning module is worth using. To know the effectiveness of developed product followed bytest field group with 30 learners. The result of t-test analysis shows the difference of learning result between pre-test and post-test.
Judging from the average score, it indicates that the developed Social Science module is effectively used in developing logical and critical thinking positions for learners on Social Science lessons in Elementary School.
The Development of Integrative Comic as a Media and Materials in Theme CitaCitaku Class IV Basic School
Authors: Ghozali Muhammad Iqbal Al , . Sarkadi , . Rusmono
Published: February 2019

This study aims is to develop integrative comics as a medium and additional teaching materials on thematic curriculum lesson 2013 theme 6 aspect of class IV of elementary school. This research uses research and development method (R and D)
Dick and Carey model with 10 stages. The study was conducted on the fourth grade students of SDN Majalengka Kulon II and SDN Majalengka Wetan VII, amounting to 75 students. Instruments used in this study in the form of interviews, questionnaires, and
test results learning. Validation results from the three experts get an average media expert score of 4.42, language experts 4.2, and material experts 4.58. Thus it can be stated that the media and comic integrative teaching materials worthy to be
used in the learning process in primary school with the condition of revision in accordance with the advice given by the three experts before The use of media and comic learning materials also get a very good response from students with a percentage
individual test 85.8% and small group test 85.3%. The effectiveness of the use of media and integrative comic learning materials can be seen from the learning outcomes after conducting field trials by providing pretest and postes questions. The data
obtained are t = 10,009 with df 74 and pvalue 0,000 tess than 0,05 or Ho is rejected. Thus it is concluded that there are differences in learning outcomes in learning the theme of 6 goals between before and after using media and integrative comic
learning materials.
Relationship with Self Concept and Regulations on Social Skills Students of Class III District SDS Pati
Authors: Terviana Ester , Sumantri Syarif , Santoso Soegeng
Published: February 2019

The purpose of this research is to know the relation between concept and self-regulation with social skill of third grade student of SDS in Pati Regency, West Java Province This research use descriptive method with correlation approach, with
sample number 95 students of class III in Regency Starch The results showed that: 1) There is a significant relationship between self-concept with social skills. This means that the higher the self-concept of the child, the higher the social skills
of the child, 2) There is a significant relationship between the child's self-regulation with the social skills of the child. This means better self-regulation of children, the better the social skills, 3) There is a significant relationship together
between self-concept and self-regulation with social skills. This means the better the self-concept and selfregulation, the better the child's social skills. Conversely, the lower the self-concept and self-regulation of children, the lower the social
skills of children.
Non Sexual Violence in Children Age
Authors: Mawani Sri , Handini Myrnawati Crie , Yetti Elindra
Published: February 2019

This study aims to examine cases of nonsexual violence in Jakarta. The focus of research is nonsexual violence in early childhood in DKI Jakarta. This research uses the qualitative approach with method case study. Techniques of collecting
data were using interviews, observation, and documentation. Data analysis was done using Miles and Hubberman models. The results showed that non-sexual violence forms of physical violence, verbal and emotional abuse of children did occur. The cause
of violence in children is only caused by some problems, but because the behavior of the perpetrator dominates the victim until the victim is still a child unable to avoid violence that resulted in one of the victims died. The trigger of violence in
children other than family disharmony, the background of economic conditions and online games is the cause of violent incidents in children. Efforts to prevent non-child sexual violence, the child should be entitled to be protected from all forms of
violence.
Nexus between Public Education Expenditure and Human Resource Development: An Empirical Analysis
Authors: Patel Geetanjali , Annapoorna Dr. M. S.
Published: February 2019

There was always a gap between recommendations and implementations especially in case of public expenditure on education which has serious implications on human resource development of the country. Lack of funding is one of the serious
concerns which may also be reason for low ranking of India in terms of Human Development Index. It can be easily observed that the total state expenditure on education in the country has hung around 3% of GDP, far below the 6% of GDP as resolved by
the National Education Policies. Descriptive method is used to study the relation between Education expenditure by the Government and Human Resource Development of India by using the secondary data collected through the reliable and authenticated
sources like Union Budgets of India and Human Development reports published by UNDP. Granger Causality Test is applied to examine the causal relation between the Public Education Expenditure and Human Resource Development. Multiple regression
analysis is used to analyse the contribution of education in Human Development Index. The result of the study will help to understand the Government’s role in Human Resource Development through expenditure on education.
The Effect of Cooperative Method and Self Efficacy toward Writing Narrative Ability
Authors: Yabas Wici Yuli Seti , Boeriswati Endry , . Fahrurozi
Published: February 2019

This study aims to know the effect of cooperative method and self-efficacy toward writing narrative ability. The method used was experimental study design using treatment by level 2x2 with analysis testing ANAVA. The results showed that:(1)
the ability to write a narrative that students learn the concept sentence method is higher than narrative writing skills of students who are learning to use a make a match method, (2) there is an interaction effect between cooperative method and
self-efficacy toward writing narrative ability, (3) the ability to write a narrative that students learn the of concept sentence is higher than the group of students who learn the make a match for students who have high selfefficacy, (4) the ability
to write a narrative that students learn the make a match is higher than the group of students who learn the concept sentence for students who have low self-efficacy. Based on the results of this study it was concluded that the cooperative method and
self-efficacy influence the students’ writing ability. Recommendation for teachers is to apply the concept sentence as a way to improve students’ writing narrative abilities.
Guidance and counseling services for early childhood
Authors: . Nasution , . Myrnawati , . Yufiarti
Published: February 2019

This research is conducted tofinding out the activity and achievement from the objectives on program and the influence on Guidance and Counseling Service at Class 1 AlAzhar Islamic Primary School 1 KebayoranBaru, Jakarta. The method of this
research was evaluation program using CIPPO models that consist of Context, Inputs, Process, and Outcomes. Data was obtained through interviews, observations, questions, and document study. Data sourcescame fromschool principals, vice principals,
guidance and counseling counselors, guidance and counseling teachers, and subject teachers. The criteria was on this evaluation was from The Letter Guidance on Implementation of Guidance and Counseling in Primary School and Regulation of the Minister
of Education and Culture RI No. 111 of 2014 on Guidance and Counseling on Basic Education and Secondary Education. The results showed that (1) in the Context dimension, there are 90.6% means that the conformity of guidance and counseling program
policy in Class 1 Al Azhar Islamic Primary School 1 KebayoranBaru, Jakarta in the context component in the category needs to be adjusted. (2) In the Inputs dimension, there were 87.3%. Thus it was included in the category adequate. This means that
curriculum, BK teachers, facilities and infrastructure, financing support, material BK on the inputs component is adequate. (3) In the Process dimension, there were 96%. Thus it was included in the appropriate category. This means that the process
component that serves the decisions related to the implementation of guidance and counseling services program is appropriate. (4) In the Product dimension, there were 88.5%. Thus included in the category agree. This means that almost all respondents
agree about a positive change from guidance and counseling services. (5) In the Outcomes dimension, there were 85.4%. Thus it was included in the good category. This means that all students get information and strategies in achieving the task of
development and eradication of the problem optimally.
Uplifting Speaking Skill through Communicative Approach at Grade V of Padurenan II State Elementary School in Bekasi of Academic Year 2016 / 2017
Authors: Hidayati Atie , Zulela MS , Fuad Nurhatati
Published: February 2019

The purpose of this research is to know how far communicative approach was able to give the correct influence of speaking skill on the Elementary School’s student. The applied method in this research was action research. This research was
implemented at Padurenan II State Elementary School in Bekasi Pursuant of processing result and analysing data, hence conclusion from this research result was significant improvement of speaking skill through communicative approach
On an alternative to Wong’s asymptotic expansion of the
Kontorovich–Lebedev transform near the origin
Authors: Naylor Derek
Published: February 2019

An asymptotic expansion is constructed for values near the origin of a
function whose Kontorovich–Lebedev transform is an even analytic function.
The expansion obtained is expressed in terms of the poles and residues of
the analytic function and provides an alternative to one obtained by Wong
(1981) which becomes inapplicable.
Composite Finite Element Approximation for Parabolic Problems in Nonconvex Polygonal Domains
Authors: Pramanick Tamal , Sinha Rajen Kumar
Published: February 2019

The purpose of this paper is to generalize known a priori error estimates of the composite finite element (CFE) approximations of elliptic problems in nonconvex polygonal domains to the time dependent parabolic problems. This is a new class of finite elements which was introduced by [W. Hackbusch and S. A. Sauter,
Composite finite elements for the approximation of PDEs on domains with complicated micro-structures,
Numer. Math. 75 1997, 4, 447–472] and subsequently modified by [M. Rech, S. A. Sauter and A. Smolianski,
Two-scale composite finite element method for Dirichlet problems on complicated domains,
Numer. Math. 102 2006, 4, 681–708] for the approximations of stationery problems on complicated domains. The basic idea of the CFE procedure is to work with fewer degrees of freedom by allowing finite element mesh to resolve the domain boundaries and to preserve the asymptotic order convergence on coarse-scale mesh. We analyze both semidiscrete and fully discrete CFE methods for parabolic problems in two-dimensional nonconvex polygonal domains and derive error estimates of order

𝒪

(

H
s

Log
^

(

H
h

)

s
2

)

{\mathcal{O}(H^{s}\widehat{\mathrm{Log}}{}^{\frac{s}{2}}(\frac{H}{h}))}

and

𝒪

(

H

2
⁢
s

Log
^

(

H
h

)

s

)

{\mathcal{O}(H^{2s}\widehat{\mathrm{Log}}{}^{s}(\frac{H}{h}))}

in the

L
∞

⁢

(

H
1

)

{L^{\infty}(H^{1})}

-norm and

L
∞

⁢

(

L
2

)

{L^{\infty}(L^{2})}

-norm, respectively. Moreover, for homogeneous equations, error estimates are derived for nonsmooth initial data. Numerical results are presented to support the theoretical rates of convergence.
Homomorphisms into totally disconnected, locally compact groups with dense image
Authors: Reid Colin D. , Wesolek Phillip R.
Published: February 2019

Let

ϕ
:

G
→
H

{\phi:G\rightarrow H}

be a group homomorphism such that H is a totally disconnected locally compact (t.d.l.c.) group and the image of ϕ is dense. We show that all such homomorphisms arise as completions of G with respect to uniformities of a particular kind. Moreover, H is determined up to a compact normal subgroup by the pair

(
G
,

ϕ

-
1

⁢

(
L
)

)

{(G,\phi^{-1}(L))}

, where L is a compact open subgroup of H. These results generalize the well-known properties of profinite completions to the locally compact setting.
On the exponent of Bogomolov multipliers
Authors: Moravec Primož
Published: February 2019

We prove that if G is a finite group, then the exponent of its Bogomolov multiplier divides the exponent of G in the following four cases: (i) G is metabelian, (ii)

exp
⁡
G

=
4

{\exp G=4}

, (iii) G is nilpotent of class

≤
5

{\leq 5}

, or (iv) G is a 4-Engel group.
Breeding population of Peregrine Falcon (Falco peregrinus) in Lazio, Central Italy: 1983–2017
Authors: Brunelli Massimo , Sarrocco Stefano
Published: February 2019

In 1983–1984 the nesting population of Peregrine Falcon (Falco peregrinus) in Lazio was estimated to 25–30 pairs located mainly in the limestone massifs of the Southern Anti-Apennines and the Ponziane Islands. The monitoring carried out in the following years showed a steady increase in population size and range. In 2014–2017, the breeding population was 166–193 pairs distributed over most of the regional territory. In four regional macro-geographic areas characterized by different morphologies, lithological and landscape typologies, the density was calculated by NND method, which varied from a minimum of 0.90 to a maximum of 1.77 pairs/100 km2; average distance between sites from 3848.18 m to 6526.87 m. The urban population of Rome increased from the first nest found in 2001 to 15 currently breeding pairs; the first artificial nest was discovered in 2001 on the building, currently 14 are known. At present in Lazio 16 nests are located in quarries. In the years 2008, 2014, 2015 and 2016, the fledging rate registered was 2.26 (SD = 0.94; bp = 153).
Monitoring of Peregrine Falcons in the Ariège Pyrenees and Toulouse, Midi-Pyrénées region, France
Authors: Pasquier Christophe , Fehlmann Mathieu , Bresson Charlotte , Fremaux Sylvain , Jean Alain , Thelliez Jean-Philippe
Published: February 2019

Since the 1980s, the volunteers of the ornithological group of the Nature Midi-Pyrénées association have been monitoring the Peregrine Falcon (Falco peregrinus) population in the Ariège Pyrenees and in the Toulouse agglomeration. The data collected over the last 30 years show stability of the Ariège population: little variation has been observed in brood size, occupation rate of the sites or reproductive success. Only the increasing number of known nesting sites is significant, due to better knowledge of the territory by observers over time. In 2017, the breeding population was estimated to be 24 pairs. Urban monitoring proved the presence of individuals in passage, wintering or resident in Toulouse. Since 2002, downtown Toulouse has been visited by several individuals of both sexes and interactions between males and females have been observed since 2005. Despite the multiplicity of possible eyries or nesting sites in Toulouse, and the massive presence of Peregrine Falcons and dedicated bird watchers, no case of breeding has been reported. In addition to monitoring, measures to protect and support the presence of the species have been put in place. In the Pyrenees, in the light of the growth of human activities near nesting sites, some sites are now subject to official protective measures, coupled with constant vigilance and awareness. In Toulouse, to encourage the breeding of the individuals present, two nesting boxes were installed in 2016, on two buildings frequented by a female and a male. In 2017, a first attempt to reproduce in one of these installations confirmed the value of such developments in urban areas.