bluuebunny/crossref_metadata_2025 huggingface dataset:
Clinical Guidelines for Sperm DNA Fragmentation (SDF) is Associated with Male Infertility from Reactive Oxygen Species (ROS)
Authors: Zakaria Mustafa , Al-ibraheemi Aya , Ennaji Mohamed , Senhaji Wassym R. , Natiq Abdelhafid , Boutiche Romaissa , Mbaye Modou M. , Zarqaoui Mohamed , Hassan Muhjah F. , Mossa Hayder A. , Louanjli Noureddine
Published: February 2022

Sperm DNA fragmentation is common in infertile male. Besides, sperm DNA integrity is essential for fertilization and healthy offspring development. Numerous genetic and environmental elements are associated with impacting sperm DNA integrity negatively. Such as lifestyle, ageing, industrial toxins, and infection. The mechanisms behind SDF are many, but apoptosis and reactive oxygen species are considered the main SDF mechanisms. The management of male infertility has led to the desire for more advanced SDF diagnostic tools to diagnose sperm DNA. Numerous sperm DNA damage assays such as terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick-end labelling (TUNEL) assay and in situ nick translation (ISNT) are available to enhance SDF diagnosing and ultimately to better SDF management. Clinical SDF can lead to a low pregnancy rate, defects in embryo development and impaired offspring health. Moreover, SDF can impact the effectiveness of assisted reproductive technology through transfer genetics impartment to the embryo b in vitro fertilization or intracytoplasmic sperm injection. SDF can be mange through lifestyle changing, treating existing infection in the male reproductive tract and reactive oxygen species.
Post-COVID-19 Vaccination Myocarditis
Authors: Niv Yaron
Published: February 2022

A cluster of young patients with myocarditis after SARS-CoV-2 RNA vaccination, started several days up to 2 weeks after the second shot, was reported in Israel, without a solid evidence for a cause and effect sequence of events, or any scientific, peer review publication. Most of the patients were young men who recovered with or without steroid therapy, but one 22 year-old woman died within 72 hours from start of the symptoms (chest pain and fatigue) with elevated troponin and CRP, ECG changes but normal echocardiogram. After injection of RNA the body manufactures the S protein and starts synthesize antibodies against it. My speculation is that the connection between S protein and the receptor ACE2, which is abundant on the myocardium, builds a stabile complex with high antigenicity. Antibodies attached to this complex which is now under attack by both – antibodies and T-cells. The result is severe inflammation and cytokine storm. Another possible explanation is the presence of a mediator between the receptor (ACE2) and S protein such as Defensin 5, and a complex of higher molecular weight and antigenicity causing a severe immunological attack.
Mental and Physiological Structures and Mechanisms of Overprotection in the Aetiology of Autoimmune Disease
Authors: Cristal-Lilov Anna , Salmon Anat Ben , Erez Ofer
Published: February 2022

Despite the prevalence of autoimmune diseases, and the variety of proposed factors involved in their aetiology, the exact cause of autoimmune disorders is still unknown [1]. As psychotherapist specializing in work with parents for the last sixteen years, and a physician who has worked with adolescents for seventeen years, in this presentation, we propose to consider the analogy between the dynamics of the overprotective family and those of the overactive immune system in autoimmune disorders, and that they are both manifestations of the structures and mechanisms of narcissistic anxiety. The overprotective parenting style is characterised by parents who present guarding behaviour that is excessive considering the child’s developmental stage and the actual risk level in their environment. Overprotective parents tend to obsess over their children’s physical and emotional safety, at a level that exceeds the actual level of risk [2]. The impact of overprotective family dynamics upon the emotional development of a child has been extensively discussed [3]. Analogous to this, autoimmune diseases are clinical manifestations of aberrant and "hyper-reactive" autoimmune responses to self-antigens of normal bodily constituents leading to inflammation, cell injury, or a functional disturbance [1]. Medical literature has suggested the correlation between emotional disorders and a variety of autoimmune diseases [4]. This presentation suggests to consider the possibility that high levels of anxiety underlie both overprotective manifestations. Instead of functioning as defence mechanisms aimed to protect the self, they are diverted into a direct attack on it.
Thulium Fiber Laser Lithotripsy in COVID Positive Patients
Authors: Alansari Abdulla , Kamkoum Hatem , Alrayashi Maged , Alnawsara Hossameldin , Tallai Bela , Gul Tawiz , Alfalahi Shukri , Abdelkareem Mohamed , Ebrahim Mohamed Ali , Aboumarzouk Omar , Salah Morshed Ali
Published: February 2022

Background: Thulium fiber laser technology has been shown to provide more power through a small fiber to enable faster stone fragmentation. In the Covid era, positive patients were postponed for a few weeks before any surgery to ensure their safety. However, with complete ureteric obstruction with large stones, delayed ureteroscopy and stone fragmentation could potentially compromise renal function. We aim to evaluate the Thulium Fiber Laser outcome as an alternative to holmium YAG laser as intracorporeal lithotripter in Covid-19 positive patients. Methods: From March-July 2020, during the peak of the corona outbreak, 11 COVID-19 positive patients were admitted through the emergency department with obstructing ureteric stones underwent urgent JJ stent insertion 2 weeks later from the initial surgery a definitive treatment offered. Results: The average age was 36+-11.7 years, all-male, all fit and healthy despite their Covid-19 status. The average stone size was 11+-3.1 mm with a volume of 395.8+-280 mm3 . The Hounsfield unit measurement was 1033.3+-57.7. Seven underwent short general anesthesia and 4 had spinal anesthesia. The average laser duration was of 593.9+-357.5 seconds, and the average stone ablation speed was 0.66+-0.19 mm3 /Sec. The overall stone- free rate was 90.9%. All 11 patients were discharged safely on the same day with only 1 patient readmitted with steinstrasse and underwent urgent ureteroscopy. None of our patients developed late complications. Conclusion: Using the Thulium laser technology allows for a quick and safe alternative to Holmium for fragmenting ureteric stones with a high stone-free rate.
The Cultural Stress Theory of Obesity
Authors: Murad Howard , Jankicevic Jasmina , Garabedian-Ruffalo Susan M.
Published: February 2022

The characteristics of modern society contribute to a condition we call Cultural Stress Anxiety Syndrome (CSAS), which is a response to the constant, pervasive, ever-increasing stress of modern living. Cultural Stress often leads to an isolated, sedentary lifestyle and a state of constant anxiety that triggers the body’s inflammation response, including the release of stress hormones linked to weight gain. Because Cultural Stress aggravates all other causes of obesity, it must be included in any effective weight management program. We present a review of the factors implicated in the obesity epidemic, as well as the implications of chronic stress on a variety of health issues. We then outline the evidence for Cultural Stress as a phenomenon that compounds other stressors, as well as the societal factors most responsible for Cultural Stress. We report on an initial pilot study that focuses on Cultural Stress-reduction as part of an inclusive health management program. We conclude that Cultural Stress is a factor in virtually all of the conditions that contribute to obesity: higher stress hormones, disrupted sleep, sedentary lifestyle, isolation, and reduced self-esteem. Supporting patients in managing Cultural Stress empowers them to effectively reduce their weight and maintain that weight loss over time.
Púrpura trombocitopênica idiopática em crianças: uma revisão narrativa
Authors: Queiroz Márilsi das Dores , Souza Ariele Assunção Ramos de , Rocha Aline Cristina Araújo Alcântara , Santos Maria das Dores dos , Almeida Danyella Rodrigues de
Published: February 2022

A Púrpura Trombocitopênica Idiopática é caracterizada pela diminuição do número de plaquetas circulantes, considerada autoimune e beningna, podendo ser classificada  de acordo com o diagnóstico, idade e duração da  doença. Objetivou-se realizar revisão da literateratura cientifica sobre a ocorrencia da pupura trombocotopênica idiopática em crianças e as possiveis intervenções de enfermagem. Trata-se de  um estudo qualitativo de revisão narrativa de carater exploratório realizado em diferentes bases de dados eletrônicas. Analisou-se que as pesquisas sobre a doença existe questões controversas sobre o diagnóstico, tratamento e acompanhamento adequado para os portadores da patologia. Desta forma é necessario que mais estudo sejam realizados com maior profundidade sobre acerca do assunto, pensando no tratamento e no aumento da expectativa de vida dos portadores dessa doença.
Relação entre o uso descontrolado de bebidas alcoólicas e perda de memória
Authors: Melo Isabela Moreira , Mesquita Jorge Vieira , Maciel Tatiana
Published: February 2022

O consumo de bebidas alcoólicas é relacionado como causa de mais de 200 tipos de doenças, principalmente, cirrose hepática, doenças cardiovasculares e vários tipos de câncer. O uso leve-moderado de bebidas alcoólicas, ao contrário do consumo pesado, não possui claros fatores de influência para as principais doenças citadas. O presente artigo teve como objetivo geral elucidar a relação do consumo descontrolado de substâncias alcoólicas com a perda de memória, baseado em pesquisas de alta credibilidade. Tratou-se de uma revisão exploratória integrativa de literatura com base na análise de onze artigos selecionados, os quais abordaram as consequências do consumo do álcool em quantidades suficientes capazes de promover alterações na homeostase do sistema nervoso central. Por meio desta revisão da neuropatologia humana relacionada ao álcool foi possível identificar alguns principais fatores que justificam as patologias causadas pelo consumo de bebidas alcoólicas. Os resultados mostraram que o consumo excessivo de álcool afeta negativamente os processos de memória episódica verbal, ou seja, armazenamento e lembrança, bem como o monitoramento de tarefas de aprendizagem verbal. Além da perda de memória, outras patologias se destacaram em todos os estudos, dentre elas tem-se os danos metabólicos ao sistema nervoso central, os danos ao hipocampo e córtex frontal, a perda da flexibilidade cognitiva e o envelhecimento acelerado. Conclui-se que existe uma relação negativa entre o consumo excessivo de substâncias alcoólicas e a perda de memória.
Perfil e intervenção fisioterapêutica dos pacientes vítimas de trauma admitidos na unidade de urgência e emergência em um Hospital Universitário do Oeste do Paraná
Authors: Bavaresco Alana Caroline , Genske Juliana Hering , Branco Carla Lautenschleger , Almeida Caio Fernandes de
Published: February 2022

Objetivos: Caracterizar o perfil das vítimas de traumas internados na sala de emergência de um Hospital Universitário do Oeste do Paraná e fazer o levantamento dos casos de trauma atendidos pelo serviço de fisioterapia, bem como as principais abordagens e condutas prestadas. Metodologia: Pesquisa observacional, retrospectiva, transversal e de caráter quantitativo, realizada através das informações dos prontuários. A amostra foi coletada através de levantamento dos pacientes que deram entrada na sala de emergência, totalizando 1.020 prontuários. A coleta de dados foi realizada no período de um ano. A análise foi realizada através de estatística descritiva simples. Resultados: Foram analisados os 1.020 prontuários, onde 17 foram excluídos por não serem efetivamente admitidos na sala de emergência. A amostra total do trabalho foi 297 prontuários, no qual a maioria é do sexo masculino com idade média de 40,26 ± 17,48 anos.  A principal causa de internação dos politraumas foi devido a traumatismo cranioencefálico. 185 pacientes necessitaram de ventilação mecânica invasiva. Quanto ao desfecho final dos pacientes, somente 55 foram a óbito. Receberam atendimento fisioterapêutico 254 pacientes. Conclusão: Os principais casos de pacientes politraumatizados foram do sexo masculino, com maior prevalência no diagnóstico de Trauma Cranioencefálico, seja isolado ou associado a outros traumas. Quanto ao desfecho final, maioria teve uma evolução satisfatória, indo de alta hospitalar. Em relação a fisioterapia, pelo número elevado de pacientes politraumatizados com necessidade de ventilação mecânica, destaca-se condutas com ênfase na fisioterapia respiratória.
Humanization of care: challenges after Covid-19 pandemic
Authors: Dias Danilo Rocha , Lages Frederico Santos , Vilaça Ênio Lacerda , Diniz Ivana Márcia Alves , Castilho Lia Silva de
Published: February 2022

Face of impacting changes in healthcare after COVID-19 pandemic, an imminent discussion is how to achieve humanization of care with so many safety barriers between healthcare providers and patients. The objective of this study is to propose an operational model to assist in the planning of actions and inspire work fronts in the fight against the Covid-19 pandemic, providing insights for future research and health policies.  A search was carried out in PubMed Central using the terms “health care models” and “humanization of care”. Studies that presented conceptual and methodological aspects of health care models were selected, in addition to experience reports and systematic reviews. From the identification of critical elements for the humanization of care, an operational model was developed suggesting the most relevant themes that require solutions and organized actions to face the Covid-19 pandemic and its consequences. The proposed themes were transdisciplinary approach, health technology, cost-effectiveness, equity, social justice, education, health promotion, information access, safety and well-being, resources distribution, sustainability. This model may be useful to organize healthcare actions based on humanization of care, involving society in a collective effort to maintain the quality of care.
Education 4.0: Value of Subjectivity in Meeting with Technology
Authors: Oliveira Valéria Marques de , Brito Hérica Landi de , Almeida Wilson de Jesus Beserra , Barbosa Marcus Vinicius , Marinho Alessandro Simões
Published: February 2022

Industry 4.0 is based on digital technological advances that demand educational processes that develop people to act in line with this scenario. Based on the ecological and systemic view, mainly on the concepts of bidirectionality and self-eco-organization, the aim of this text is to reflect on the effect of the connection between education 4.0 and industry 4.0 in Brazil in the constitution of subjectivity. Narrative review was applied in the fields of History and Philosophy of Education, Brazilian Industrialization and Educational and Organizational Psychology, to support a Brazilian socio-historical reading of the four industrial revolutions and their parallel with education, the influence on the Brazilian subjective position is inferred. Ethically positioned in terms of human and professional training, it is argued that technological advances should be at the service of human beings and not the other way around. In this sense, we conclude that dialogic and emancipatory education, aware of its subjective influence, has an important role in social justice. The appreciation of subjectivity supported by the construction of autonomy and thought authorship can serve as key elements to educational success in connection with Industry 4.0.
Análise da prevalência da Síndrome de von Hippel-Lindau em pacientes portadores de hemangioblastomas do Sistema Nervoso Central
Authors: Fonseca Gustavo Soares Gomes Barros , Freire Vivianne Maria Laranjeiras Monte , Bonfim Lais Lima , Penha Elana Cristina da Silva , Guimarães João Victor Araújo , Pereira Raphael Erick Lima , Macedo Gabriel de Sousa , Britto Filipe Augusto Lopes Cajubá de , Murad Letícia Muniz de Abreu , Brito Alessandra do Rosário , Reis Lara Letícia Teixeira , Santos Amanda Cordeiro , Mesquita Neto Agostinho Rodrigues , Prazeres Julianne Souza , Cunha Luiza Mariana Batista Lima , Maia Ana Vitória Feitosa Barroso , Silva Carolynne Weba da , Borges Fernando de Abreu , Almeida Monaliza Brito de , Vieira Samantha Cunha , Soares Isabela Coelho Brito , Tapety Sá Liciana , Pereira Lucca Adriano , Bezerra Thalita Martins , Soares Ivana Mota , Sousa Rebeca Machado Castro , Coelho Maria Beatriz Celedonio , Caldeira Felipe Ramos
Published: February 2022

Hemangioblastomas (HBs) são neoplasias benignas comumente localizadas no cerebelo e medula espinhal e podem surgir de forma esporádica ou relacionados à Síndrome de von Hippel-Lindau (VHL). Quando há associação com a VHL, tumores multifocais podem surgir, diferentemente dos esporádicos, que são isolados. A VHL é uma doença hereditária relacionada ao desenvolvimento de tumores benignos e malignos, sendo os mais comuns os hemangioblastomas do Sistema Nervoso Central e os angiomas de retina. A doença é causada pela ineficácia do gene supressor de tumor VHL (pVHL) em um alelo no cromossomo 3p25-26. A presença da VHL em pacientes com HBs leva o paciente a um pior prognóstico, por facilitar a metastatização. Dessa forma, o objetivo da seguinte revisão é analisar a prevalência da Síndrome de von Hippel-Lindau em pacientes portadores de hemangioblastomas do Sistema Nervoso Central (SNC). Trata-se de uma revisão bibliográfica sistemática que utilizou as plataformas PubMed, SciELO e Google Scholar como bases de dados para pesquisa de artigos científicos, com recorte temporal entre 2016 e 2022, na língua inglesa. De acordo com o mecanismo de busca, 4 resultados foram encontrados após os critérios de exclusão nas bases de dados PubMed e Google Scholar. Constatou-se, portanto, que há moderada prevalência da VHL em pacientes portadores de HBs do SNC. Dentre os estudos, a menor taxa de prevalência da VHL em pacientes com HBs foi de 23%, enquanto a maior taxa foi de aproximadamente 60%, com uma média geral de ± 39,2%, ao serem considerados todos os estudos que envolveram esses pacientes.
Contribuições de um projeto de extensão durante pandemia por COVID-19: relato de experiência
Authors: Santos Thaiane Santana , Ramos Willamis Tenório , Pinheiro Fernanda Gomes de Magalhães Soares , Freitas Carla Kalline Alves Cartaxo , Mendes Rosemar Barbosa , Barreiro Maria do Socorro Claudino
Published: February 2022

Objetivo: Discutir as contribuições e os impactos da extensão universitária “Alô, Comunidade” para extensionistas e sociedade. Método: Estudo descritivo de abordagem qualitativa, na modalidade relato de experiência, desenvolvido a partir das vivências e experiências de criação e postagem de podcasts proporcionados pela própria ação de extensão. Resultados: Nesta primeira fase da extensão, foram produzidos 10 podcasts informativos, voltados para a disseminação de conhecimento sobre educação em saúde contextualizada no cenário de pandemia provocada pelo novo coronavírus (SARS-CoV-2). Os podcasts foram estruturados e gravados pelos extensionistas com orientação dos docentes e divulgados através das redes sociais. Conclusão: As ações construídas e desenvolvidas por meio do projeto de extensão “Alô, Comunidade” tornaram-se importantes estratégias de ensino e aprendizagem no período atual. A disseminação de conhecimento dentro área da saúde, por meio da utilização de recursos digitais de informação e comunicação, beneficiou ouvintes e extensionistas. Além disso, desenvolveram-se habilidades essenciais para a futura prática profissional dos discentes, tais como a comunicação, trabalho em equipe e domínio tecnológico.
Screening the Varietal Resistance and Mating Disruption Management of Cotton Bollworm Helicoverpa armigera and Pectinophora gossipyilla at Sibi Balochistan
Authors: Khuhro Sajjad Ali , Jatoi Ghulam Hussain , Laghari Umed Ali , Zangejo Khan Muhammad , Shamim Asim
Published: February 2022

Cotton bollworms cause huge losses and are mainly controlled through the synthetic chemicals, however, chemical control does not always effective due to the larvae’s obscure feeding habit. Therefore, varietal resistance and insect mating disruption by using of sex pheromone and light traps were used in present research. The results revealed overall highest seasonal population of Helicoverpa armigera (3.75±0.37) on cotton SS-32 variety, followed by (2.41±0.17), (2.35±0.21), and (2.00±0.19), IUB-13, Nayab-878, and J-5 Pectinophora gossypiella (3.00 ± 0.72) on cotton variety Nayab-878 followed by population of 2.99±0.27, 2.50±0.31, and 1.65±0.22 on cotton varieties J-5, SS-32 and IUB-13 respectively. In addition, maximum yield production was recorded from J-5 (1025 kg ha-1), followed by Nayab-878 (962 kg ha-1) and IUB-13 (835 kg ha-1), respectively. Results, of field trials revealed overall H. armigera (61.25±5.28/15 sex pheromone traps ha-1) followed by (37.45±6.28/10 ha-1) and (20.79 ± 4.28 /6 ha-1) and P. gossipyilla (58.08±7.58 ha-1) followed by (45.41±4.88/10 ha-1) and (31.45±3.28/6 ha-1) were captured, respectively. Further, lowest infestation level of H. armigera (2.25±0.28%/15 sex pheromone traps ha-1) followed by (6.60±0.80 %/10 ha-1), (6.60±0.80% /10 ha-1) and (20.45±4.80% control plots) and P. gossipyilla (2.10±0.21 %/15 ha-1) followed by (7.41±0.96 %/10 ha-1), (9.45±0.98 % /10 ha-1) and (19.15 ± 4.87 % control plots) were recorded, respectively. On the other hand, maximum number of H. armigera (24.30±4.35 /8 light traps ha-1) followed by (22.00±3.30/6 ha-1) and (17.50±3.12 /4 ha-1) were recorded and P. gossipyilla (24.00±4.28 /6 ha-1) followed by (21.00±3.40 /8 ha-1) and (20.15±2.70 /4 ha-1) were caught, respectively. As results, the lowest infestation level by H. armigera (7.60±1.12 % /6 light traps ha-1) followed by (8.25±1.20 % /8 ha-1), and (10.79±1.80 % /4 ha-1) and (20.45±4.80 % control plots) and P. gossipyilla (6.10±0.90 % /8 ha-1) followed by (7.45±1.15 % /6 ha-1), (8.40±1.38 % /4 ha-1) and (19.15±4.87% control plots) were recorded, respectively. Taken to gather, 10 or 15 sex pheromone traps/hectare and 6 and 10 light traps/ hectare should be installed in cotton crop to reduce the population frequency of bollworm and crop damage tendency in the cotton field for the better production.
EVALUASI PENERAPAN ANGGARAN BIAYA OPERASIONAL SEBAGAI ALAT PERENCANAAN DAN PENGENDALIAN (Studi Kasus pada PT Bumi Sarana Beton Cabang Kendari)
Authors: Intihanah Intihanah , Safaruddin Safaruddin , Alfia Alfia
Published: February 2022

Penelitian ini bertujuan untuk mengetahui dan menjelaskan penerapan anggaran biaya operasional sebagai alat perencanaan dan pengendalian pada PT. Bumi Sarana Beton Cabang Kendari. Data yang digunakan adalah data primer dan data sekunder. Metode pengumpulan data dalam penelitian ini adalah wawancara dan dokumentasi. Analisis data yang digunakan adalah analisis deskriptif. Hasil penelitian ini menunjukkan bahwa pada PT. Bumi Sarana Beton Cabang Kendari masih terdapat beberapa penyimpangan, yaitu penyimpangan yang bersifat menguntungkan (Favorable) dan tidak menguntungkan (Unfavorable) berdasarkan hasil perhitungan analisis varians yang dilakukan dari tahun 2017-2019. Penyimpangan tersebut disebabkan oleh beberapa faktor yaitu faktor internal antara lain adalah penggunaan dana yang kurang optimal dan faktor eksternal diantaranya adalah inflasi dan keadaan tak terduga (alam).
TINJAUAN ATAS PERLAKUAN AKUNTANSI LINGKUNGAN PADA RUMAH SAKIT UMUM DAERAH (RSUD) BAHTERAMAS
Authors: Abdullah Muntu , Hadisantoso Erwin , Trisaktiani Eka
Published: February 2022

Penelitian ini bertujuan untuk mengetahui bagaimana perlakuan akuntansi lingkungan terhadap pengelolahan limbah pada RSUD Bahteramas menyangkut Identifikasi, pengukuran, pengakuan, penyajian, dan pengungkapannya serta bagaimana proses pengelolaan limbah dan tanggung jawab sosial di RSUD Bahteramas. Metode penggumpulan data menggunakan dokumentasi, studi kepustakaan dan wawancara. Analisis data menggunakan metode analisis deskriptif.Hasil penelitian ini menunjukan bahwa RSUD Bahteramas dalam mengidentifikasi akuntansi biaya lingkungannya, diakui sebagai komponen beban barang dan jasa, beban pemeliharaan dan belanja modal yang digolongkan ke dalam akun belanja operasional. Penyajiannya bersama-sama dengan biaya-biaya yang sejenis dalam laporan keuangan. Dan pengungkapannya masuk ke dalam catatan atas laporan keuangan RSUD Bahteramas. Sedangkan untuk pengelolaan limbahnya, RSUD Bahteramas sudah mengelola limbahnya dengan baik sehingga dapat dikatakan bahwa RSUD Bahteramas sudah melakukan tanggung jawab sosial terhadap lingkungan di sekitarnya. Kesimpulan dari penelitian ini menunjukan bahwa RSUD Bahteramas belum menyajikan laporan khusus mengenai akuntansi lingkungannya secara lebih rinci di dalam laporan keuangan rumah sakit. RSUD Bahteramas sudah melakukan tanggung jawab sosialnya sebagai organisasi yang kegiatan operasionalnya menghasilkan limbah yang berbahaya
ANALISIS IMPLEMENTASI ENTERPRISE RESOURCES PLANNING DALAM MENINGKATKAN KINERJA SATUAN PENGAWASAN INTERN PTPN XIV PERSERO UNIT KEBUN ASERA
Authors: Awaluddin Ishak , Hadisantoso Erwin , Al Ayyubi Saldi
Published: February 2022

Penelitian ini bertujuan untuk mengetahui dan menjelaskan implementasi sistem ERPdalam meningkatkan kinerja Satuan pengawasan internal PT Perkebunan XIV. Metodepengumulan data menggunakan wawancara, observasi dan dokumentasi. Penelitian initermasuk dalam penelitian kualitatif yang menggunakan metode analisis deskriptif.Berdasarkan hasil penelitian Mengenai implementasi Enterprise Resource Planning dalammeningkatkan kinerja auditor internal dapat di simpulkan bahwa implementasi EnterpriseResource Planning tidak memberikan dampak yang sangat fositif dalam menigkatkan kinerjasatuan pengwasan internal baik dari segi melaksanakan tugas dan fungsinya, pemeriksaanaudit akan tetapi memiliki dampak yang cukup baik bagi kinerja perusahaan yang dikarenakan informasi entitas di dapatkan lebih cepat sehingga proses monitoring dapat dilakukan dengan efektif. Kurang baiknya dampak yang di berikan oleh Enterprise ResourcePlanning sebabkan oleh kurangnya pemahaman auditor internal dalam menggunakan sistemEnterprise Resource Planning di lingkup satuan kerja pengawasan internal PT perkebunanXIV serta data yang di hasilkan oleh ERP SAP belum terinci.
PENGARUH SIMPANAN DAN PINJAMAN ANGGOTA TERHADAP SISA HASIL USAHA (STUDI PADA KOPERASI SERBA USAHA BINA SEJAHTERA, DESA LEMOAMBO, KABUPATEN MUNA BARAT)
Authors: Basru Wawo Andi , Nurnaluri Sitti , Rahman Fathu
Published: February 2022

Penelitian ini bertujuan untuk menguji dan mengetahui pengaruh Simpanan danPinjaman Anggota terhadap Sisa Hasil Usaha Koperasi pada Koperasi Serba UsahaBina Sejahtera. Metode pengumpulan data dalam penelitian menggunakandokumentasi. Data yang digunakan adalah data sekunder berupa catatan simpanananggota, pinjaman anggota, dan Sisa Hasil Usaha. Metode penelitian yang digunakanadalah metode analisis deskriptif dan analisis regresi linear berganda dengan bantuanaplikasi software IBM SPSS Statistic Versi 25. Hasil penelitian ini menunjukkan bahwa(1) simpanan anggota secara parsial berpengaruh signifikan dan positif terhadap SisaHasil Usaha Koperasi, (2) pinjaman anggota secara parsial berpengaruh signifikan danpositif terhadap Sisa Hasil Usaha, (3) serta simpanan dan pinjaman anggota secarasimultan berpengaruh signifikan terhadap Sisa Hasil Usaha Koperasi. Kesimpulandalam penelitian ini yaitu semakin meningkat jumlah simpanan anggota dan pinjamananggota akan meningkatkan jumlah Sisa Hasil Usaha Koperasi.
PENGARUH MODAL USAHA, PERSEDIAAN, DAN JAM KERJA TERHADAP PENDAPATAN PEDAGANG PADA MASA PANDEMI COVID-19 (STUDI KASUS PASAR BARUGA)
Authors: Arifuddin Arifuddin , Dharmawati Tuti , Karlina Lilis
Published: February 2022

Penelitian ini bertujuan untuk mengetahui pengaruh modal usaha, persediaan, danjam kerja terhadap pendapatan pedagang pasar Baruga di masa pandemi Covid-19 secaraparsial maupun simultan. Populasi penelitian ini berjumlah 784 pedagang. Metodepengambilan sampel adalah stratified random sampling menggunakan rumus Slovinsebanyak 89 sampel. Metode pengumpulan data dalam penelitian ini menggunakandokumentasi, kuesioner, dan wawancara. Analisis data yang digunakan dalam penelitian iniadalah analisis regresi linear berganda.Hasil penelitian ini menunjukkan bahwa (1) modalusaha berpengaruh signifikan terhadap pendapatan pedagang pasar Baruga di masapandemi Covid-19; (2) persediaan berpengaruh signifikan terhadap pendapatan pedagangpasar Baruga di masa pandemi Covid-19; (3) jam kerja berpengaruh signifikan terhadappendapatan pedagang pasar Baruga di masa pandemi Covid-19; (4) modal usaha,persediaan, dan jam kerja berpengaruh secara simultan terhadap pendapatan pedagangpasar Baruga di masa pandemi Covid-19.
PENGARUH PENGGUNAAN INFORMASI AKUNTANSI TERHADAP KINERJA USAHA, MIKRO, KECIL, DAN MENENGAH (UMKM) DI KOTA KENDARI
Authors: Safaruddin Safaruddin , Abdullah Muntu , Zulhijayanti Syahrir Irda
Published: February 2022

Penelitian ini bertujuan untuk mengetahui dan menganalisis pengaruhpenggunaan informasi akuntansi terhadap kinerja usaha mikro, kecil, dan menengah(UMKM) di Kota Kendari. Sampel pada penelitian ini menggunakan teknik purposivesampling, dan pengukuran sampel menggunakan rumus slovin, dari penentuan sampeldiperoleh 50 pengusaha. Metode pengumpulan data menggunakan kuesioner. Analisisdata menggunakan metode statistik deskriptif dan analisis regresi sederhana. Hasilpenelitian ini menunjukkan bahwa Penggunaan Informasi Akuntansi berpengaruhsignifikan terhadap Kinerja Usaha Mikro, Kecil, dan Menengah (UMKM) di KotaKendari di bidang fashion (pakaian jadi). Kesimpulannya bahwa penggunaan informasiakuntansi dapat digunakan untuk meningkatkan kinerja usaha mikro, kecil, danmenengah (UMKM). Bila manajemen mampu untuk mengoptimalkan penggunaaninformasi akuntansi secara signifikan maka dengan demikian kinerja usaha mereka akanmeningkat signifikan.
EVALUASI PENGELOLAAN KEUANGAN BANTUAN OPERASIONAL SEKOLAH (BOS) PADA SMAN 1 TALAGA RAYA
Authors: Nurnaluri Sitti , Nurdin Emilia , Umardin Umardin
Published: February 2022

Penelitian ini bertujuan untuk mengetahui bagaimana perencanaan, pelaksanaan,penggunaan, pelaporan dan pertanggungjawaban, serta bagaimana pengawasan danevaluasi dana Bantuan Operasional Sekolah (BOS) di SMAN 1 Talaga Raya. Jenis datadalam penelitian ini adalah data kualitatif. Sumber data dalam peneitian ini yaitubersumber dari data primer dan data sekunder. Metode pengumpulan data yangdigunakan dalam penelitian ini adalah wawancara dan dokumentasi. Hasil penelitian inimenunjukkan bahwa pengelolaan keuangan Bantuan Operasional Sekolah (BOS) padaSMA Negeri 1 Talaga Raya sudah sesuai dengan petunjuk teknis dana BOS nomor 3tahun 2019 yang terdiri dari tahapan perencanaan, pelaksanaan, penggunaan, pelaporandan pertanggungjawaban, serta pengawasan dan evaluasi. Pada tahapan perencanaan,dimulai dari penyusunan RKAS yang dilaksanakan pada awal tahun ajaran, namun darisegi transparansi tidak membuat spanduk atas penggunaan dana BOS.
PENGARUH PERAN ACCOUNT REPRESENTATIVE (AR) DAN SANKSI PAJAK TERHADAP KEPATUHAN WAJIB PAJAK ORANG PRIBADI (Studi Pada KPP Pratama Kendari)
Authors: Abdullah Muntu , Lestari Labangu Yuli , Fadia Haya Akilla
Published: February 2022

Penelitian ini bertujuan untuk mengetahui pengaruh peran Account Representativedan Sanksi Pajak terhadap kepatuhan wajib pajak orang pribadi pada KPP PratamaKendari. Data yang digunakan dalam penelitian ini adalah data kualitatif dan kuantitatif.Populasi penelitian ini adalah wajib pajak orang pribadi sebanyak 148.428 wajib pajak.Penentuan sampel dilakukan dengan sampling insidental, dihitung berdasarkan rumusslovin dan sampel sebanyak 100 repsonden. Pengumpulan data dilakukan menggunakankuisioner. Metode analisis yang digunakan adalah metode analisis regresi linearberganda. Hasil dari penelitian ini menunjukan bahwa peran Account Representativeberpengaruh signifikan terhadap kepatuhan wajib pajak orang pribadi, Sanksi Pajakberpengaruh signifikan terhadap kepatuhan wajib pajak orang pribadi, dan secarasimultan peran Account Representative dan Sanksi Pajak berpengaruh signifikanterhadap kepatuhan wajib pajak orang pribadi pada KPP Pratama Kendari.
Three-Dimensional Innate Mobility of the Human Foot on Coronally-Wedged Surfaces Using a Biplane X-Ray Fluoroscopy
Authors: Negishi Takuo , Nozaki Shuhei , Ito Kohta , Seki Hiroyuki , Hosoda Koh , Nagura Takeo , Imanishi Nobuaki , Jinzaki Masahiro , Ogihara Naomichi
Published: February 2022

Improving our understanding on how the foot and ankle joints kinematically adapt to coronally wedged surfaces is important for clarifying the pathogenetic mechanism and possible interventions for the treatment and prevention of foot and lower leg injuries. It is also crucial to interpret the basic biomechanics and functions of the human foot that evolved as an adaptation to obligatory bipedal locomotion. Therefore, we investigated the three-dimensional (3D) bone kinematics of human cadaver feet on level (0°, LS), medially wedged (−10°, MWS), and laterally wedged (+10°, LWS) surfaces under axial loading using a biplanar X-ray fluoroscopy system. Five healthy cadaver feet were axially loaded up to 60 kg (588N) and biplanar fluoroscopic images of the foot and ankle were acquired during axial loading. For the 3D visualization and quantification of detailed foot bony movements, a model-based registration method was employed. The results indicated that the human foot was more largely deformed from the natural posture when the foot was placed on the MWS than on the LWS. During the process of human evolution, the human foot may have retained the ability to more flexibly invert as in African apes to better conform to MWS, possibly because this ability was more adaptive even for terrestrial locomotion on uneven terrains. Moreover, the talus and tibia were externally rotated when the foot was placed on the MWS due to the inversion of the calcaneus, and they were internally rotated when the foot was placed on the LWS due to the eversion of the calcaneus, owing to the structurally embedded mobility of the human talocalcaneal joint. Deformation of the foot during axial loading was relatively smaller on the MWS due to restricted eversion of the calcaneus. The present study provided new insights about kinematic adaptation of the human foot to coronally wedged surfaces that is inherently embedded and prescribed in its anatomical structure. Such detailed descriptions may increase our understanding of the pathogenetic mechanism and possible interventions for the treatment and prevention of foot and lower leg injuries, as well as the evolution of the human foot.
One-Pot Three-Component Coupling Reaction of α-Amino Aryl Ketones, Indoles, and Perbromomethane Under Mild Conditions
Authors: Chen De , Lu Hao , Liu Yuxuan , Deng Wei , Qiu Renhua , Xiang Jiannan
Published: February 2022

A simple and efficient one-pot three-component cascade reaction of α-amino aryl ketones, indoles, and CBr4 in moderate to good yields has been developed. This new strategy exhibits excellent mild reaction conditions and step-economy, easily accessible reactants, and simultaneous construction of three different new bonds (C=N, C–C, and N-Br) in a single step. It is worth noting that the protocol developed provides a simple and practical tool for the construction of diverse indole-containing heterocyclic frameworks, indicating its potential applications in medicinal and material chemistry.
Influence of Geographical Location on Maternal-Infant Microbiota: Study in Two Populations From Asia and Europe
Authors: Cheng Yue , Selma-Royo Marta , Cao Xin , Calatayud Marta , Qi Qi , Zhou Jing , Zeng Lingxia , Garcia-Mantrana Izaskun , Collado Maria Carmen , Han Bei
Published: February 2022

Early gut microbial colonization is driven by many factors, including mode of birth, breastfeeding, and other environmental conditions. Characters of maternal-neonatal microbiota were analyzed from two distinct populations in similar latitude but different continents (Oriental Asia and Europe). A total number of 120 healthy families from China (n=60) and Spain (n=60) were included. Maternal and neonatal microbiota profiles were obtained at birth by 16S rRNA gene profiling. Clinical records were collected. Geographical location influenced maternal-neonatal microbiota. Indeed, neonatal and maternal cores composed by nine genera each one were found independently of location. Geographical location was the most important variable that impact the overall structure of maternal and neoantal microbiota. For neonates, delivery mode effect on neonatal microbial community could modulate how the other perinatal factors, as geographical location or maternal BMI, impact the neoantal initial seeding. Furthermore, lower maternal pre-pregnancy BMI was associated with higher abundance of Faecalibacterium in maternal microbiota and members from Lachnospiraceae family in both mothers and infants. At genus-level, Chinese maternal-neonate dyads possessed higher number of phylogenetic shared microbiota than that of Spanish dyads. Bifidobacterium and Escherichia/Shigella were the genera most shared between dyads in the two groups highlighting their importance in neonatal colonization and mother-infant transmission. Our data showed that early gut microbiota establishment and development is affected by interaction of complex variables, where environment would be a critical factor.
Characteristics of Helicobacter pylori Heteroresistance in Gastric Biopsies and Its Clinical Relevance
Authors: Wang You-hua , Gong Xiao-ling , Liu Ding-wei , Zeng Rong , Zhou Lin-fu , Sun Xiao-yan , Liu Dong-sheng , Xie Yong
Published: February 2022

Background

Antimicrobial susceptibility testing (AST) plays a vital role in anti-Helicobacter pylori treatment, but the traditional AST method has difficulty detecting heteroresistance, which may cause an increased prevalence of resistant strains and eradication failure.

Aims

To investigate the characteristics of heteroresistance in H. pylori in gastric biopsies and investigate its clinical relevance.

Method

A total of 704 gastric biopsies were selected for 23S rRNA and gyrA gene sequencing, 470 H. pylori isolates from these biopsies were selected for AST, and the clinical characteristics of the patients were reviewed.

Result

For the 699 biopsies that were positive for 23S rRNA gene, 98 (14.0%) showed a heteroresistance genotype, and a wild type (WT) combined with A2143G (86.7%) genotype was found in most samples. For the 694 biopsies that were positive for gyrA gene, 99 (14.3%) showed a heteroresistance genotype, and a WT combined with 87K (26.3%) or WT combined with 91N (23.2%) genotype was predominant. According to the E-test results, the resistance rates of heteroresistance genotype samples for clarithromycin and levofloxacin were 36.2% and 68.1%, respectively. When dividing the heteroresistance samples into different groups according to the sequencing profile peaks of the mutation position, the resistance rates were higher along with mutation peaks at the mutation position. In addition, patients infected with mutated or heteroresistant strains showed lower peptic ulcer detection rates than those infected with the WT strain (p < 0.05).

Conclusion

Heteroresistance genotypes for clarithromycin and levofloxacin were not rare in H. pylori. Most cases with a heteroresistance genotype showed a susceptible phenotype for clarithromycin and a resistance phenotype for levofloxacin. Patients infected with heteroresistance genotype strains showed a lower peptic ulcer detection rate than those infected with the WT strain.
High Plasma Concentration of Apolipoprotein C-III Confers an Increased Risk of Cerebral Ischemic Events on Cardiovascular Patients Anticoagulated With Warfarin
Authors: Olivieri Oliviero , Turcato Gianni , Cappellari Manuel , Stefanoni Filippo , Osti Nicola , Pizzolo Francesca , Friso Simonetta , Bassi Antonella , Castagna Annalisa , Martinelli Nicola
Published: February 2022

Introduction

Apolipoprotein C-III (Apo CIII) is a crucial regulator of triglyceride-rich lipoproteins (TRLs) and influences the risk of cardiovascular diseases. High levels of Apo CIII have been also associated with cerebrovascular events and earlier works showed procoagulant effects of Apo CIII. The main aim was to assess whether the plasma concentration of Apo CIII could confer an increased risk of cerebral ischemic events in anticoagulated patients at high-risk of cardioembolism.

Methods

We systematically checked medical records and quantified cerebral ischemic events in a selected cohort of 118 subjects [median age 68 with interquartile range (IQR) 59–75 years, 66.9% males, 52.5% with coronary artery disease (CAD)], taking anticoagulant therapy with warfarin because of atrial fibrillation (AF) and/or mechanical prosthetic heart valves. All the subjects, enrolled between May 1999 and December 2006, were prospectively followed until death or July 31, 2018. Assessments of complete plasma lipid and apolipoprotein profiles, including Apo A-I, B, CIII, and E, were available for all subjects at enrollment.

Results

After a median follow-up of 109 months (IQR, 58–187), 24 subjects (20.3%) had cerebral ischemic events: stroke (n = 15) and TIA (n = 9). Subjects with plasma concentration of Apo CIII above the median value (10.3 mg/dL) had an about three-fold increased risk of stroke/TIA than those with lower levels of Apo C-III [hazard ratio 3.08 (95%CI, 1.22–7.77)]. This result was confirmed in multiple Cox regression models adjusted for gender, age, CAD, AF, diabetes, hypertension, plasma lipids, and CHA2DS2-VASc score. By stratifying the sample on the basis of Apo CIII level and CHA2DS2-VASc score, an additive effect was observed with the highest risk in subjects with both high Apo C-III concentration and CHA2DS2-VASc score.

Conclusion

High Apo CIII plasma levels may be associated with an increased risk of ischemic stroke/TIA in high-risk cardiovascular patients anticoagulated with warfarin.
Impact of Physical Activity on All-Cause Mortality According to Specific Cardiovascular Disease
Authors: Kim Moon-Hyun , Sung Jung-Hoon , Jin Moo-Nyun , Jang Eunsun , Yu Hee Tae , Kim Tae-Hoon , Pak Hui-Nam , Lee Moon-Hyoung , Lip Gregory Y. H. , Yang Pil-Sung , Joung Boyoung
Published: February 2022

Background

Patients with cardiovascular disease (CVD) tend to have higher mortality rates and reduced physical activity (PA). We aimed to evaluate the effect of PA on mortality in older adults with specific CVD.

Methods

We enrolled 68,223 participants (n = 23,871 with CVD, n = 44,352 without CVD) aged ≥65 years with available physical activity data between 2005 and 2012 from the Korean National Health Insurance Service of Korea-Senior database. CVD was defined as a history of ischemic stroke, transient ischemic attack, heart failure, myocardial infarction, and peripheral artery disease.

Results

Patients with CVD were older than those without CVD. Compared with the sedentary group, the physically active groups with and without CVD had a lower incidence and risk of all-cause death during a median follow up period of 42 (interquartile range 30–51) months. A 500 metabolic equivalent task-min/week increase in PA resulted in an 11% and 16% reduction in the risk of mortality in the non-CVD and CVD groups, respectively. With regard to specific CVDs, the risk of mortality progressively reduced with increasing PA in patients with heart failure or myocardial infarction. However, the reduction reached a plateau in patients with stroke or peripheral artery disease, but was significantly greater in patients with stroke (20% vs. without stoke, 11%, Pint = 0.006) or heart failure (13% vs. without heart failure, 11%; Pint = 0.045)

Conclusions

PA was associated with a reduced risk of all-cause mortality in older adults with and without CVD. The benefits of PA in patients with CVD, especially patients with stroke or heart failure, were greater than those without.
Effectiveness of Amiodarone in Preventing the Occurrence of Reperfusion Ventricular Fibrillation After the Release of Aortic Cross-Clamp in Open-Heart Surgery Patients: A Meta-Analysis
Authors: He Li-min , Zhang An , Xiong Bin
Published: February 2022

Objective

To evaluate the efficiency of amiodarone in preventing the occurrence of reperfusion ventricular fibrillation (RVF) after aortic cross-clamp (ACC) release in patients undergoing open-heart surgery.

Methods

We searched the Web of Science, Cochrane Library, EMBASE, and PubMed databases through January 2021 for relevant studies addressing the efficacy of amiodarone in preventing RVF after ACC release in patients undergoing cardiac surgery. A complete statistical analysis was performed using RevMan 5.3. Risk ratios (RRs) and 95% confidence intervals (CIs) were calculated to express the results of dichotomous outcomes using random or fixed-effect models. The chi-square test and I2 test were used to calculate heterogeneity.

Results

Seven studies (856 enrolled patients; 311 in the amiodarone group, 268 in the lidocaine group, and 277 in the placebo group) were selected for the meta-analysis. The incidence of RVF was significantly decreased in the amiodarone group compared to the placebo group (RR = 0.69, 95%CI: 0.50–0.94, P = 0.02). However, amiodarone and lidocaine did not confer any significant difference (RR = 0.98, 95%CI: 0.61–1.59, P = 0.94). The percentage of patients requiring electric defibrillation counter shocks (DCSs) did not confer any significant difference between patients administered amiodarone and lidocaine or placebo (RR = 1.58, 95%CI: 0.29–8.74, P = 0.60; RR = 0.55, 95%CI: 0.27–1.10, P = 0.09; respectively).

Conclusions

Amiodarone is more effective than a placebo in preventing RVF after ACC release in cardiac surgery. However, the amiodarone group required the same number of electrical DCSs to terminate RVF as the lidocaine or placebo groups.
Deciphering Cell-Cell Communication in Abdominal Aortic Aneurysm From Single-Cell RNA Transcriptomic Data
Authors: Yang Huan , DeRoo Elise , Zhou Ting , Liu Bo
Published: February 2022

Cell-cell communication coordinates cellular differentiation, tissue homeostasis, and immune responses in states of health and disease. In abdominal aortic aneurysm (AAA), a relatively common and potentially life-threatening vascular disease, intercellular communications between multiple cell types are not fully understood. In this study, we analyzed published single-cell RNA sequencing (scRNA-seq) datasets generated from the murine CaCl2 model, perivascular elastase model, Angiotensin II model, and human AAA using bioinformatic approaches. We inferred the intercellular communication network in each experimental AAA model and human AAA and predicted commonly altered signaling pathways, paying particular attention to thrombospondin (THBS) signaling between different cell populations. Together, our analysis inferred intercellular signaling in AAA based on single-cell transcriptomics. This work provides important insight into cell-cell communications in AAA and has laid the groundwork for future experimental investigations that can elucidate the cell signaling pathways driving AAA.
Case Report: “Gourd-Shaped” Heart Strangled by Localized Annular Calcification of the Left Ventricle: A Rare Case of Constrictive Pericarditis
Authors: Yang Zhiyun , Wang Hui , Lv Qiang , Du Xin , Zhu Junming , Dong Jianzeng
Published: February 2022

We report a rare case of a 43-year-old woman with calcific annular constrictive pericarditis (CP) encircling the basal segment of the right ventricle and the mid-segment of the left ventricle (LV) lateral wall. Over time, localized calcification has caused LV to be tightly strangled and shaped like a gourd. However, multimodality imaging confirmed no significantly clinical constriction associated with decreased cardiac movement and function. Additionally, cardiac magnetic resonance feature tracking confirmed the relatively preserved diastolic function and the characteristic “plateau” pattern of CP. The treatment strategy of this case is challenging and dialectical.