bluuebunny/crossref_metadata_2025 huggingface dataset:
Rekomendasi Adaptive Re-Use Pada Gedung Radio Republik Indonesia Di Makassar
Authors: Moh. Sutrisno  , Anugrah Sandy Nur Arya
Published: February 2023

Bangunan Tua merupakan warisan arsitektur yang cenderung memiliki nilai-nilai sejarah. Salah satu bangunan tua di Makassar adalah Gedung Radio Republik Indonesia (RRI) yang terletak di tengah kawasan kota Tua Makassar. Gedung RRI tidak termasuk dalam daftar bangunan cagar budaya, akan tetapi gedung tersebut terindikasi memiliki nilai-nilai sejarah. Gedung RRI termasuk salah satu bangunan yang rawan upaya pembongkaran maupun rehabilitasi. Pemerintah mengeluarkan aturan terbaru tahun 2022 tentang Objek Diduga Bangunan Cagar Budaya (ODCB). Penelitian menggunakan metode kualitatif. Hasil penelitian menunjukkan pentingnya adaptive reuse di ruang dalam bangunan gedung RRI. Selain itu, Citra kawasan bertambah baik jika dilakukan relokasi masjid dari halaman utama gedung ke bagian samping bangunan.
Insulin receptor substrate-1 gene polymorphism and lipid panel data in type 2 diabetic patients with comorbid obesity and/or essential hypertension
Authors: Marushchak Mariya , Mazur Lyudmyla , Krynytska Inna
Published: February 2023

Objective. The hallmarks of type 2 diabetes mellitus (T2DM) are insulin resistance (IR) and insulin receptor substrate (IRS) proteins essential for the insulin signaling. IRS-1 gene has not only been shown to be associated with T2DM, but also has indicated that it may significantly correlate with diabetic complications, such as coronary heart disease and obesity. The aim of this study was to evaluate changes of the lipid panel data in T2DM patients with comorbid obesity and/or essential hypertension in connection with the IRS-1 (rs2943640) polymorphism.

Methods. The study involved 33 T2DM patients and 10 healthy individuals. The IRS-1 (rs2943640) polymorphism was genotyped using a TaqMan real-time polymerase chain reaction method. Blood serum lipid panel data were determined with commercially available kits using a Cobas 6000 analyzer.

Results. Analysis of the serum lipid panel data depending on the presence of the C/A alleles of IRS-1 (rs2943640) polymorphism in T2DM patients, regardless of the presence/absence of comorbidities, showed significantly lower level of high-density lipoprotein cholesterol (HDL-C) and significantly higher level of non-HDL-C in the carriers of C allele vs. carriers of A allele. In T2DM patients with comorbid obesity and essential hypertension, proatherogenic lipid changes were found in both C and A alleles carriers. Analysis of the effect of IRS-1 (rs2943640) genotypes on serum lipid panel data in T2DM patients, regardless of the presence/absence of comorbidities, showed that the CC genotype carriers had more pronounced pro-atherogenic changes vs. carriers of СА and АА genotypes. In the comorbid course of T2DM (both in combination with obesity and obesity and essential hypertension), pro-atherogenic changes were found in the carriers of the CA genotype of IRS-1 (rs2943640) polymorphism.

Conclusions. The presence of the C allele of IRS-1 (rs2943640) polymorphism in both homo-zygous and heterozygous states indicates increased risk of pro-atherogenic changes in T2DM patients with comorbid obesity and/or essential hypertension.
ERN1 dependent impact of glucose and glutamine deprivations on PBX3, PBXIP1, PAX6, MEIS1, and MEIS2 genes expression in U87 glioma cells
Authors: Krasnytska Dariia O. , Viletska Yuliia M. , Minchenko Dmytro O. , Khita Olena O. , Tsymbal Dariia O. , Cherednychenko Anastasiia A. , Kozynkevych Halyna E. , Oksiom Nataliia S. , Minchenko Oleksandr H.
Published: February 2023

Objective. Homeobox genes play a fundamental role in the embryogenesis, but some of them have been linked to oncogenesis. The present study is aimed to investigate the impact of glucose and glutamine deprivations on the expression of homeobox genes such as PAX6 (paired box 6), PBX3 (PBX homeobox 3), PBXIP1 (PBX homeobox interacting protein 1), MEIS1 (MEIS homeobox 1), and MEIS2 in ERN1 knockdown U87 glioma cells with the intent to reveal the role of ERN1 (endoplasmic reticulum to nucleus signaling 1) signaling pathway on the endoplasmic reticulum stress dependent regulation of homeobox genes.

Methods. The control (transfected by empty vector) and ERN1 knockdown (transfected by dominant-negative ERN1) U87 glioma cells were exposed to glucose and glutamine deprivations for 24 h. The cells RNA was extracted and reverse transcribed. The expression level of PAX6, PBX3, PBXIP1, MEIS1, and MEIS2 genes was evaluated by a real-time quantitative polymerase chain reaction analysis and normalized to ACTB.

Results. It was found that glucose deprivation down-regulated the expression level of PAX6, MEIS1, and MEIS2 genes in control glioma cells, but did not significantly alter PBX3 and PBXIP1 genes expression. At the same time, ERN1 knockdown significantly modified the sensitivity of all studied genes to glucose deprivation. Other changes in gene expression were detected in control glioma cells under the glutamine deprivation. The expression of PBX3 and MEIS2 genes was down- while PAX6 and PBXIP1 genes up-regulated. Furthermore, ERN1 knockdown significantly modified the effect of glutamine deprivation on the majority of studied genes expression in U87 glioma cells.

Conclusion. The results of the present study demonstrate that the exposure of U87 glioma cells under glucose and glutamine deprivations affected the expression of the majority of the studied homeobox genes and that the sensitivity of PAX6, PBX3, PBXIP1, MEIS1, and MEIS2 genes expression under these experimental conditions is mediated by ERN1, the major pathway of the endoplasmic reticulum stress signaling.
Measuring and Analyzing the Efficiency of Firms in the Insurance Industry Using DEA Techniques
Authors: Vintilă Alexandra , Trucmel Irina-Maria , Roman Mihai Daniel
Published: February 2023

The insurance industry has an important role in the economy, being constantly focused on diversifying product portfolios and dispersing risks. Since the uncertainty, the asymmetric information, the current economic and social-political challenges affect the economic performance and competitiveness on the insurance market, it is necessary to focus on the evaluation of the technical efficiency of the players. One of the most complex analytical research tools with increased utility that can be applied to measure the efficiency is the Data Envelopment Analysis (DEA). Our work is designed to analyze the performance of a sample made up of the ten main players in the insurance industry in Romania. Assuming a predefined set of five inputs (total expenses, provisions, average number of employees, total placements and intangible assets) and one output (total income) selected from the firms’ balance sheets, we calculate the efficiency scores with the help of DEA techniques for each year from 2016 to 2020. Our results show that Allianz and City are the most efficient firms regardless of the model type VRS or CRS, while Groupama and Omniasig fail to operate at an optimal level in any of the analyzed periods.
Waste Management. The Trigger of Circular Economy
Authors: Maricuţ Alin-Cristian , Grădinaru Giani-Ionel , Matei Florin-Bogdan
Published: February 2023

The circular economy has increasingly attracted the attention of regulators as a result of the emergence of the challenges associated with climate change and the need to increase the lifetime of goods in order to reduce waste and high consumption of resources. Therefore, the paper aims to identify the current state of the circular economy in Romania by analyzing waste recovery in territorial profile. Also, another objective of the work is to identify the gaps in the territorial profile of the recovery rate of collected waste. To achieve the goals of the research, appropriate statistical methods were used in this study, such as: the Jenks algorithm and the Gini Coefficient. The main results of research suggest there are a lot of gaps in territorial profile from recycling rate perspective and a low concern about circular economy in Romania.
The Role of procollagen type 1 amino-terminal propertied (P1NP) Cytochrome P450 (CYPs) and Osteoprotegerin (OPG) as Potential Bone function markers in Prostate Cancer Bone Metastasis
Authors: Yousif Pshtiwan A. , Ismail Parween Abdulsamad
Published: February 2023

Background: Procollagen type I amino-terminal propeptide (PINP) is often present during osteoblast development and could be a biomarker of early bone development. Osteoprotegerin (OPG) may protect tumor cells from apoptosis. Cytochrome P450 enzymes help tumor development and treatment (CYPs). Cytochrome P450 activates and deactivates anticancer drugs and procarcinogens.

Objective: The study examined the amounts of a diagnostic marker of bone formation, the amino terminal propeptide of type I procollagen (PINP), Osteoprotegerin (OPG), and P450, in prostate cancer patients at different stages and its ability to detect osteoblastic metastases.

Methods: ELISA was used to measure PINP, OPG, and P450 levels in 30 prostate cancer patients. (n = 32) and healthy men’s serum (n = 36).

Results: Prostate cancer patients had higher blood levels of PINP, OPG, and P450 than healthy persons (301.3±134.9, 980±467.2, and 84.2±28.4 pg/mL, respectively). Compared to I+II prostate cancer patients, III+IV patients showed higher serum PINP, OPG, and P450 levels (P 0.001). OPG, P450, and PINP had statistically significant Area under the ROC curve (0.9467, P= 0.0001, 0.91, P= 0.0001, and 0.6977, P= 0.4035) in prostate cancer patients.

Conclusions: Metastatic prostate cancer patients had greater PINP, OPG, and P450 levels, according to our findings. PINP, OPG, and P450 levels may affect prostate cancer progression. These findings imply that serum PINP, OPG, and P450 levels may predict and diagnose prostate cancer.
Beyond the Whiteness
Authors: Quagliati Noemi
Published: February 2023

Saverio Salvioni, Cava di Ravaccione, 1810–1813 (Source: Archivio di Stato Massa e Pontremoli)
 
Marble extraction in the Italian Apuan Alps has been known since Roman times, and its historical importance is symbolized by masterpieces of Western art history. However, the Carrara marble industry has recently received harsh criticism for operating in the protected area of the Apuan Alps Regional Park, recognized by UNESCO since 2015. Environmental and social concerns about mining have arisen from the extreme acceleration of all the productive phases of the extractive industry. From the mid-twentieth century, the exploitation of geological deposits of marble grew exponentially thanks to the development of powerful extraction technologies and a global export economy that creates only relatively few occupations in Carrara.
Within this context, photographic and cinematographic projects have increasingly focused on the environmental risks created by the marble mining industry. This article shows how visual representations of Carrara have changed in recent years via an analysis of three case studies: the internationally acclaimed documentary Anthropocene: The Human Epoch (2018), the climbing project and Italian short film Carie (Cavity 2019), and Lorenzo Shoubridge’s naturalistic photographs in Apuane: terre selvagge (Apuan Wildlands 2018).
These case studies offer an innovative perspective on the landscapes of marble extraction. Previously, these landscapes were represented following other visual trends emphasizing the technological sublime found in the geometric shapes of the white quarries, the working conditions of marble laborers, and the myth of the purity of marble used in artistic sculptures. The three examples analyzed in this paper attempt to go ‘beyond the whiteness’ by focusing on the scale of environmental destruction (Anthropocene: The Human Epoch), the more-thanhuman perspective (Apuane terre selvagge), and the social struggle for preserving a mountain region through creative solutions (Carie). In other words, new aesthetic and ethical sensibilities are challenging established twentieth-century narratives of the Carrara marble quarries by focusing on a new element: the environment.
PENGARUH JUMLAH FUNGSI KEANGGOTAAN PADA METODE FUZZY LOGIC TERHADAP HASIL PERAMALAN BEBAN LISTRIK JANGKA PANJANG
Authors: Renartha Kusuma Sani , Sari Hartati Rukmi , Sukerayasa I Wayan
Published: February 2023

Electric load in Sumbawa Besar Regency from 2011 - 2018 experienced an average increase of ± 6.6%. The electric load for the following year is not yet known, so forecasting is needed. Electric load forecasting has an important role in the energy management system. Many methods can be used for forecasting, one of them is the fuzzy logic method. Fuzzy logic method consists of 3 components, those are Fuzzification, Fuzzy Inference System, and Defuzzification. Fuzzification is an important component of the fuzzy logic method, so the proper configuration is needed in order to produce forecasting that is close to the actual data. The simulation was carried out in 3 conditions, those are the first conditions (3 membership functions), the second condition (5 membership functions), and the third condition (7 membership functions). The third condition obtained a MAPE value of 2,42%, while the second condition was 3,34%, and the first condition was 6,51%. The third condition obtained the simulation results in 2026 at 24,75MW, while the second condition was at 23,26 MW, and the first condition was at 20,97MW. The third condition is the best condition in this study, because it has the smallest MAPE value.
RANCANG BANGUN SISTEM PERINGATAN DINI BAHAYA AKTIVITAS GUNUNG BERAPI BERBASIS MIKROKONTROLER ARDUINO
Authors: Vincensio Simon Michael Angelo , Setiawan Widyadi , Sastra Nyoman Putra
Published: February 2023

This research aims to design and build an early warning system device of volcanoactivity hazards based on Arduino microcontroller that can monitor changes in temperature, soilmoisture and tremor through sensors placed in the environment around the crater. This earlywarning system of volcano activity hazards is relatively simple but can be very useful to helpgovernment institutions and also the public which will reduce the risk of data collection directlyand also speed up the public to get information so that they can avoid the radius of danger. Theearly warning system of volcano activity hazards is also flexible with wifi coverage areas thatrange more than 100 meters. Based on research and test that has been done shows that thesystem created has a good effectiveness and flexibility which is able to send monitoring resultsto the ThingSpeak and then display it on a smartphone application in realtime.
RANCANG BANGUN SISTEM MONITORING PADA HIDROPONIK NFT (NURTIENT FILM TEHCNIQUE) BERBASIS IOT
Authors: Pamungkas Lindu , Rahardjo Pratolo , Raka Agung I Gusti Agung Putu
Published: February 2023

The use of hydroponics is an effective way to carry out farming activities without theneed for large tracts of land. Hydroponics requires extra supervision to be able to produceplants with good quality. There are three main parameters in hydroponics, namely the amountof dissolved nutrient content, the pH level in water, and the water suhue level. To provideconvenience in conducting surveillance, this research designed an IoT-based NFT hydroponicmonitoring system. The use of TDS sensors, pH sensors, and temperatur sensors DS18B20 inthis study are used to measure any changes that occur in the three parameters. Sensor datawill be processed by Arduino Mega 2560 and sent to Firebase databases via NodeMCUESP8266 which is connected to the internet network, so users can supervise anytime andanywhere through the android mobile application.
The Correlation of Education, Work, and Mother's Age with The Completeness of Basic Immunization in Toddlers at Puskesmas Kuok-Riau in Period of January-June 2013
Authors: Pratama Yanasta Yudo , Yaoma Sifa Anisa , Susyanto Bambang Edi
Published: February 2023

Immunization prevents some dangerous diseases for children. Completeness of basic immunization is influenced by several factors. This study aims to determine the relationship between education, occupation, and maternal age with the completeness of basic immunization. This type of research is descriptive quantitative analytic with cross sectional method. This research was conducted in July 2013 at the Kuok-Riau Public Health Center. The number of samples is 75 and selected by non-probability sampling. Immunization status at the age of 30, 67.3% completed basic immunization and 32.7% did not complete basic immunization. For mothers aged 30 years, 30.4% completed basic immunization and 69.68% did not complete basic immunization. For mothers with education <9 years, 37.9% did not graduate and 62.1% graduated. For mothers with 12 years of education, 67.4% graduated and 32.6% did not graduate. For working mothers, 68.3% completed and 31.7% did not. Housewives, 41.2% completed and 58.8% did not. The results of correlation analysis with Chi-Square test obtained p-value 0.005 (p<0.05), education with immunization, p-value 0.017 (p<0.05), work status with immunization, p-value 0.022 (p<0 ,05). There is a relationship between maternal educational status, maternal employment status, and maternal age with immunization status.
Surgery for Chronic Back Pain or Chronic Neck Pain – Does It Work?
Authors:   University Of Southern California, Adams James David
Published: February 2023

The mechanism of chronic pain does not provide a rationale for surgical intervention. Alternative therapies can be effective against chronic pain.
The Spinal is a Key to Treat Diseases, the Interaction between Meridians and Fasciae
Authors:   Ming Chuan University, Wu Jih-Huah
Published: February 2023

Finally, it affect the efficiency of any treatment. In this article, two cases that reveal the relationships of fascia and meridian are presented
Desain Ruang Unit Kerja Rekam Medis Berdasarkan Aspek Ergonomi Di Puskesmas Senduro
Authors: Qolbi M Mahbub Jauhar , Roziqin Mochammad Choirur
Published: February 2023

Kenyamanan lingkungan kerja dapat membantu dalam meningkatkan produktivitas kerja parapetugas dalam memberi pelayanan di Puskesmas, sehingga pasien mendapatkan pelayananmaksimal. Ruang kerja unit rekam medis di Puskesmas Senduro belum memenuhi aspekkenyamanan dikarenakan keadaan ruangan yang sempit hanya berukuran 9 m2sehinggaberdampak terhadap pelayanan dan ruang filing yang berukuran 7,5 m2tidak sesuai denganstandar minimal yaitu sebesar 20 m2. Meja, kursi dan rak filing memiliki ukuran yang tidaksesuai dengan antropometri petugas serta sarana dan prasana lain yang masih belum sesuaidengan kebutuhan petugas. Jenis penelitian ini menggunakan metode kualitatif dengan teknikpengumpulan data melalui hasil observasi, wawancara, dokumentasi dan brainstorming. Hasilpenelitian menunjukkan bahwa perlu adanya desain ruang unit kerja rekam medis baru yangdisesuaikan dengan standar pedoman dan alur pengolahan berkas rekam medis serta desainmeja, kursi dan rak filing yang disesuaikan dengan antropometri petugas. Desain ruang unitkerja rekam medis baru berukuran 10m x 6m yang sudah disesuaikan dengan standar/teori dandidesain menggunakan aplikasi SketchUp 3D 2020 sesuai dengan aspek ergonomi yangmeliputi efisiensi, kesehatan, keselamatan, kemanan dan kenyamanan. Saran untuk Puskesmas
Perancangan dan Pembangunan Sistem Pendaftaran Online Pasien Rawat Jalan di RSUD Asembagus Situbondo
Authors: Shalihin Firman , Wicaksono Andri Permana , Farlinda Sustin , Pratama Mudafiq Riyan
Published: February 2023

Proses pendaftaran pasien rawat jalan di RSUD Asembagus Situbondo terdiri atas pendaftaran offline dan online melalui aplikasi WhatsApp. Permasalahan yang sering terjadi pada pendaftaran offline adalah penumpukan pasien di loket pendaftaran dikarenakan jumlah pasien berkunjung dan jumlah petugas tidak sebanding, sedangkan pada pendaftaran online sering terjadi pesan pasien mendaftar yang tertimbun, yang mengakibatkan pasien tidak terlayani dengan baik. Dampak yang dapat ditimbulkan dari hal-hal tersebut adalah persepsi pasien maupun keluarga terhadap mutu rumah sakit yang belum tertata dan kurang baik. Tujuan dari penelitian ini adalah merancang dan membangun sistem pendaftaran online rawat jalan di RSUD Asembagus Situbondo. Penelitian ini menggunakan metode FAST dengan jenis penelitian kualitatif dan teknik pengumpulan data yang digunakan adalah observasi, wawancara dan studi literatur dalam merancang sistem pendaftaran online pasien rawat jalan. Hasil penelitian ini adalah sistem pendaftaran online pasien rawat jalan RSUD Asembagus Situbondo yang dapat membantu mempercepat dan mempermudah proses pendaftaran seperti pencatatan data pasien serta membantu kinerja dari petugas pendaftaran rawat jalan.
Karakteristik Pasien Keratosis Seboroik Lanjut Usia di Poliklinik Kulit dan Kelamin RSUP Dr. M. Djamil Padang
Authors: Hamzany Tisa , Gustia Rina , Ilahi Fitratul
Published: February 2023

Latar Belakang: Keratosis seboroik merupakan salah satu tumor jinak kulit terbanyak yang dilaporkan pada kelompok umur lanjut. Usia, sinar matahari, genetik dan pekerjan berperan penting dalam faktor risiko peningkatan proses terbentuknya lesi keratosis seboroik. Tujuan penelitian ini adalah untuk mengetahui gambaran karakteristik pasien keratosis seboroik lanjut usia di RSUP Dr. M. Djamil Padang.
Objektif:  Penelitian ini bertujuan untuk mengetahui gambaran karakteristik pasien keratosis seboroik lanjut usia di RSUP Dr. M. Djamil Padang.
Metode: Penelitian ini merupakan penelitian deskriptif observasional dengan desain cross sectional dengan total sampel yaitu 20 sampel pasien lanjut usia yang didiagnosis keratosis seboroik. Penelitian dilakukan di RSUP Dr. M. Djamil Padang pada periode Januari 2019 – Desember 2021.
Hasil: Penelitian ini menunjukkan kelompok usia terbanyak pada rentang usia 60-70 tahun (60%), pekerjaan pasien keratosis seboroik lanjut usia ditemukan lebih banyak di luar ruangan (60%) dengan lama paparan sinar matahari sebesar >6 jam/hari (45%). Gejala subjektif sebesar 55% berupa gatal lebih banyak ditemukan. Wajah adalah lokasi tersering ditemukannya lesi keratosis seboroik pada lanjut usia (51,4%). Durasi sebelum terapi pasien keratosis seboroik lanjut usia sebagian besar >15 tahun (65%) dan untuk pilihan terapi terbanyak adalah elektrokauterisasi (45,2%).
Kesimpulan: Kesimpulan penelitian ini adalah sebagian besar kasus keratosis seboroik lanjut usia di poliklinik RSUP Dr. M. Djamil Padang berumur 60 – 70 tahun, bekerja di luar ruangan, di bawah sinar matahari selama >6 jam/hari, merasakan gatal, ditemukan di wajah, menderita >15 tahun dan mendapatkan terapi elektrokauter.
Reconstruyendo 50 años del Colegio Colombiano de Terapia Ocupacional
Authors: Alfonso Romero Miguel Angel , Jaramillo Rodríguez Khristian , Mora Estrella Laura Violetha
Published: February 2023

A través de una línea del tiempo se exponen hechos significativos en la historia del Colegio Colombiano de Terapia Ocupacional. Esta se elaboró como parte de un trabajo de grado en la Universidad Nacional de Colombia, el cual tuvo como objetivo revisar y reportar hallazgos en el archivo histórico del Colegio y de dicha Universidad. Se rastrearon y clasificaron documentos de archivo histórico y se recurrió a la validación con actores clave. La línea del tiempo expone una breve muestra de lo encontrado en ese proceso. Como reflexión del grupo de estudiantes, la agremiación es una herramienta social para la construcción colectiva y dinámica desde procesos democráticos y críticos.
Green Synthesis of Silver Nanoparticles via Black and Green Tea and Study its Toxicity on few Vital Organs of Female Mice
Authors: Ibraheem Shaima R. , Al-Ogaidi Israa . , Al-Azawi Hassan F.
Published: February 2023

This study included synthesizing silver nanoparticles (AgNPs) in a green method using AgNO3 solution with glucose exposed to microwave radiation. The prepared NPs were also characterized using ultraviolet and visible (UV-vis) spectroscopy and scanning electron microscopy (SEM). The UV/vis spectroscopy confirmed the production of AgNPs, while SEM analysis showed that the typical spherical AgNPs were 30 nm and 50 nm in size for the NPs prepared using black tea (B) and green tea (G) as reducing agent, respectively. The changes in some of the biochemical parameters related to the liver and kidneys have been analyzed to evaluate the probable toxic effects of AgNPs. 40 adult male mice were included in this study. To assess the probable health effects of the prepared AgNPs, an experiment has been designed that includes 40 adult mice, and it was randomly divided into three groups as follows: Group I (C): The control group consisting of 10 animals was injected intraperitoneally with PBS for 15 days. Second (G): included 10 animals who were injected with 0.1 mL of (2) mg/kg (G) intraperitoneally for 15 days. Group B included 10 animals injected with 0.1 mL of (2 mg/kg) (B) solution intraperitoneally for 15 days. Changes in some biochemical parameters related to the liver and kidneys were analyzed to assess potential toxic effects on the function of these vital organs. The serum levels of alanine aminotransferase (ALT)(IU/L), alkaline phosphatase (ALP) (IU/L), and cholesterol (mg/dL) as parameters of liver function were analyzed, and the serum levels of uric acid, creatinine, and urea (mg/dL) were analyzed as parameters of kidney function. The results revealed that no significant changes occurred in organ weight in groups treated with AgNPs compared with the control. However, the results showed a significant increase in ALT enzyme level in the third group compared with its level in the control group. Meanwhile, there were no significant differences in ALT level between the second group and the control. The level of the anaplastic lymphoma kinase (ALK) enzyme was significantly increased in both groups (2 and 3) in comparison with its level in the control group. No significant differences were found in cholesterol levels between the groups. Also, there were no significant differences found in uric acid levels between the groups. At the same time, creatinine level increased significantly in group 2 (where the NPs prepared using Black tea as a reducing agent) compared to its level in the control group. Urea level increased significantly in both groups (2 and 3) in comparison with its level in the control group. We conclude that the submission to AgNPs causes toxicity in the liver and kidneys.
Evaluation of Acute Oral Toxicity of the Emblica officinalis Phytosome Formulation in Wistar Rats
Authors: Mane Varsha B. , Killedar Suresh G. , More Harinath N. , Tare Harshal L.
Published: February 2023

Emblica officinalis, commonly known as amla, belongs to the Euphorbiaceae family. The herbal medicine phytosome was used to create a novel drug delivery system to extract E. officinalis fruit. E. officinalis fruit extract phytosome (EOP) formulation was tested for toxicity, and the LD50 cut-off value was determined using female wistar rats weighing 95 to 105 g. Acute toxicity testing was performed on a total of 12 female wistar rats, with three rats in each of the four groups as per 423 organisation for economic co-operation and development (OECD) guidelines. A single oral dose of the EOP formulation at 300, 300, 2000, and 2000 mg/kg body weight was administered to groups I, II, III, and IV. For 14 days, we monitored all of the animals to see if any of them died, developed any clinical symptoms, or put on any significant weight. There were no fatalities among the animals, and notable distinctions between the two groups were not found in terms of observed clinical symptoms or animal body weight. At the time of the gross necropsy, no abnormalities were discovered. The phytosome (EOP) formulation of E. officinalis has been shown to be non-lethal and tolerable at 2000 mg/kg bw. 5000 mg (mg/kg) of LD50 were selected for this investigation.
Electrocatalytic Reduction and Voltammetric Determination of Curcumin by Blood Medium
Authors: Al-Omairi Ibtihal H. A. , Radhi Muhammed M. , Mohsin Ahmed A.
Published: February 2023

Curcumin is a chemical produced from the Curcuma longa family. Curcumin compounds can be used in various types of cancers. The study focused on the electrochemical properties of curcumin in the blood medium. The redox reaction of curcumin in blood was studied by cyclic voltammetry (CV) using a glassy carbon electrode (GCE) to find each of the electrochemical parameters such as different concentrations, pH, scan rates, and reliability (stability). In-vitro experiments found that the activity of curcumin in the blood has good behavior against disease through the interaction of curcumin molecules with blood components that have only one peak reduction current that appeared at a voltage of -0.750 V. A good indication for these reactions is to serve as an antioxidant reagent enhanced by the alkaline medium (pH = 8) of the blood medium. Also, the curcumin compounds present in the alkaline medium can be used for patients suffering from cancer diseases.
Biokinetic Model Development of 177Lu-labeled Methylene Diphosphonate as a Radiopharmaceutical Treatment
Authors: Zakaly Hesham MH , Mostafa Mostafa YA , Zhukovsky Micael .
Published: February 2023

177Lu is a lanthanide radionuclide. In recent years, the possibility of applying a drug based on the 177Lu radionuclide as a palliative treatment for bone metastases has increased. 177Lu has many prospects in terms of its applications in nuclear medicine. The high-energy beta particles and the relatively short half-life of the radionuclide are used to provide an effective treatment. In this work, a comparison of organ and tissue doses is performed with two different drugs: 177Lu in an ionic radionuclide form and 177Lu labeled methylene diphosphonate (177Lu-MDP). 177Lu in an ionic form actively accumulates in the liver and bones. Phosphonate compounds form stable radio-labeled complexes. This suggests that 177Lu-MDP is a non-dissociated form of the drug. The distribution and elimination of the drug occur according to the kinetics of the carrier, i.e., methylene diphosphonate. It is shown that the use of an osteotropic complex (describing any drug that is attracted to and targets bone) allows for the concentration of a large dose in pathological areas and minimizes damage to healthy organs and tissues.
Prevalence of Plasmodium Species among Humans and Monkeys at Mole National Park in Northern Ghana
Authors:   School of Medical Laboratory Science, UDS, Ghana, E Dadzie , EM Rebecca ,   School of Medical Laboratory Science, UDS, Ghana, L Quaye ,   College of Allied Health Sciences, UDS, Tamale, Ghana, G Helegbe ,   School of Medicine, UDS, Ghana, MY Ziekah ,   Department of Game and Wildlife, Ghana, BB Abubakari ,   Regional Health Directorate, Tamale, Ghana, Y Aniweh ,   West African Centre for Cell Biology of Infectious Pathogens, Ghana, A Abdul-Karim ,   Public Health Laboratory, Tamale, Ghana
Published: February 2023

Malaria is one of the most severe public health problems in Ghana. In developing countries such as Ghana, with high of prevalence of malaria, the procedures for diagnoses and detection is limited in technological depth and for that reason most of these parasites; Plasmodium ovale, Plasmodium malariae, Plasmodium vivax and Plasmodium knowlesi are not routinely screened for; as such this study seeks to determine the prevalence of Plasmodium species among humans and monkeys at Mole National Park in Northern Ghana. A total sample size of 217 comprising 214 human subjects and 3 baboons were recruited in this study conducted at Mole National Park. Data including; age, marital status, gender, occupation, knowledge on malaria and educational background information were collected. Blood samples were taken from both humans and baboons for the malaria testing using RDT, Microscopy and PCR to detect Plasmodium falciparum, Plasmodium ovale, Plasmodium malariae, Plasmodium vivax and Plasmodium knowlesi. The mean age of the study participants was 24.2±15.2. All the 3 baboon subjects were negative on RDT but one (1) out of the three was positive on microscopy. That notwithstanding, the same microscopy positive baboon subject was Pan-Plasmodium positive on PCR but was negative for the tested Plasmodium falciparum, Plasmodium ovale and Plasmodium malariae. The study recorded prevalence of plasmodium species using RDT and microscopy respectively to be 22.9% and 18.2%. The prevalence of Plasmodium falciparum, Plasmodium ovale and Plasmodium malariae among the human participants from this study were 39.9%, 12.6% and 18.6% respectively. Mixed infections were identified in 7.5% of the human participants where 4.2% was Plasmodium falciparum/Plasmodium ovale, 2.8% was falciparum/malariae mixed infection and 0.5% malariae/ovale mixed infection. Sociodemographics, knowledge on malaria and interaction with monkeys of study participants did not show any significant association with malaria infection. Prevalence of malaria parasites was high among the participant, which poses threat to reduction of malaria in the country.
Evidence for an Estrogen Disruptor Driven Meta-Epidemic Including Hygiene Hypothesis Related Potentiation and Beneficial Effects Related to the Obesity Paradox
Authors:   Wauwatosa, WI, USA, M Lubinsky
Published: February 2023

Evidence is presented for an estrogen disruptor related meta-epidemic with three overlapping waves. The first arose in the 1930s with animal intersexes, but few apparent human effects, and involved substances such as halogenated biphenyls and DDT. The second began around 1960 and continues today, with obvious ongoing human epidemics with diverse estrogenic effects, connections to hygiene hypothesis related immune disorders that explain epidemic timing, and health benefits related to strokes, heart attacks, and cognition where alternative medical explanations are insufficient. A single novel disruptor with dual estrogenic effects explains similar timing for adverse and beneficial changes. Dual effects could also account for the obesity paradox, where excess weight improves outcomes with other diseases, since the same agent that causes obesity could also ameliorate sequelae. Bisphenol A, a common constituent of plastics, is a likely candidate, with detectable levels in humans, including fetuses, estrogen disruption in vitro, and multiple links to epidemic findings. Production and use are historically consistent with early epidemic changes. Bisphenol S, a common replacement, is probably equally harmful. First and second waves exposures overlap, and a third wave involves chronic effects and interactions.
The Hummingbird Sign
Authors:   Department of Neuroradiology, Mohamed V University, Rabat, Morocco, B Wilson , A Waïs ,   Department of Neuroradiology, Mohamed V University, Rabat, Morocco, EZ Sara ,   Department of Neuroradiology, Mohamed V University, Rabat, Morocco, K Raïssa ,   Department of Neuroradiology, Mohamed V University, Rabat, Morocco, EK Najwa ,   Professor, Department of Neuroradiology, Mohamed V University V, Rabat, Morocco, F Meryem ,   Professor, Department of Neuroradiology, Mohamed V University V, Rabat, Morocco, J Mohammed ,   Professor, Chef of Service, Department of Neuroradiology, Mohamed V University, Rabat, Morocco, T Firdaous ,   Professor, Department of Neuroradiology, Mohamed V University V, Rabat, Morocco
Published: February 2023

Progressive supranuclear palsy also known as Steele-Richardson syndrome (PSP-RS) is a neurodegenerative disease that manifests as axial rigidity, unstable posture, and supranuclear gaze palsy. Thus, there is a marked atrophy of the middle of the brain involving midbrain. The MRI will show on the median sagittal slices weighted in T1 the sign of the Humming-bird or the sign of the Penguin (Figure 1) which describes the flat or concave aspect of the mesencephalic tegmentum. This sign, which recalls the appearance of the beak of the Hummingbird Bird or the beak of the Penguin (Figure 2), is typical of PSP-RS, with a specificity of 99.5% [1]. This sign is often associated with the Morning Glory Sign which has a specificity of 97.7%, observed on axial slices weighted of the MRI, corresponding to the concave aspect of the lateral margin of the Tegmentum of the midbrain [2]. Those appearance reflect a reduction in the anteroposterior diameter of the mesencephalon testifying to its atrophy [1,2].
The Cleanable VP Shunt Illustrations: Clinical Images
Authors:   Radiology Specialist, Department of Radiology, Al-Namas General Hospital, Ministry of Health, Al-Namas City, Saudi Arabia, A Alahmari
Published: February 2023

The aim of this paper is to illustrate the proposed idea by Mr. Abdulwhab Alahmari in the paper entitled “Proposal of a Cleanable VP Shunt for Hydrocephalus” [1]. This illustration will highlight the invention’s important details and illustrate the fundamental parts of the proposed VP shunt (Figure 1-8).
An Interesting Case of Post Covid Mucormycosis with Rhino-Cerebro-Orbital Involvement
Authors:   Department of Radiodiagnosis, Dr. Ram Manohar Lohia Institute of Medical science, Lucknow, India, RA Gaurav , S Bhanupriya ,   Department of Radiodiagnosis, Dr. Ram Manohar Lohia Institute of Medical science, Lucknow, India, S Ankur ,   Department of Radiodiagnosis, Dr. Ram Manohar Lohia Institute of Medical science, Lucknow, India
Published: February 2023

Mucor mycosis is an uncommon fungal infection which has ability to invade blood vessels and can affect different part of the body, the most common and most aggressive form being rhino-cerebro-orbital mucormycosis that occur in immunocompromised patient. We describe a case of rhino-cerebro-orbital mucormycosis in a post vaccinated diabetic patient.
On the question of the periodic solutions of a system of differential equations describing the oscillations of two loosely coupled Van der Pol oscillators
Authors: Баева Ольга Владимировна , Куликов Дмитрий Анатольевич
Published: February 2023

Изучается система двух слабосвязанных полностью идентичных осцилляторов Ван дер Поля в случае диффузионной связи.В работе изучен в полном объеме вопрос о существовании и устойчивости периодических решений рассматриваемой системы. Показано, что у нее могут быть периодические решения трех типов, которые порождают циклы Андронова-Хопфа, противофазный, и третий тип циклов синхронизации: асимметричные циклы. Анализ задачи использовал метод нормальных форм Пуанкаре-Дюлака, а также метод интегральных многообразий.

We study a system of two weakly coupled completely identical van der Pol oscillators in the case of diffusion coupling. the question of the existence and stability of periodic solutions of the system under consideration. It is shown that it can have periodic solutions of three types, which generate Andronov-Hopf cycles, antiphase, and the third type of synchronization cycles: asymmetric cycles. The analysis of the problem used the Poincare-Dulac method of normal forms, as well as the method of integral manifolds.
Pengaruh Latihan Kekuatan Arm Muscles dan Abdominal Muscles Terhadap Shooting Bola Tangan (Studi Pada Atlet Bola Tangan Bojonegoro)
Authors: Al-ayyubi Iwan Burhannudin , Januardi Irawan Roy
Published: February 2023

Latar Belakang: Penelitian ini bertujuan untuk mengetahui pengaruh kekuatan otot perut dan otot lengan terhadap lemparan (shooting)  pada atlet bola tangan Bojonegoro.

Metode: Dalam penelitian metode yang digunakan adalah deskriptif kuantitatif. Untuk mengetahui hasil lemparan (shooting) ini diukur menggunakan instrumen standing shoot test, sedangkan variabel otot perut dan otot lengan menggunakan instrumen sit up dan push up.

Hasil: Hasil dari penelitian ini menunjukkan bahwa shooting bola tangan di pengaruhi oleh banyak aspek, salah satunya adalah kekuatan otot lengan dan otot perut.

Kesimpulan: Secara individu kekuatan otot lengan memberikan pengaruh paling besar terhadap variabel shooting yang dilakukan dalam bola tangan. Kesimpulannya variabel kekuatan otot lengan dan otot perut sangat berpengaruh terhadap variabel shooting yang dilakukan dalam olahraga bola tangan secara individual maupun bersama-sama.
PENGARUH SISTEM PENILAIAN KINERJA MENGGUNAKAN RATING BINTANG TERHADAP KINERJA DENGAN DISIPLIN KERJA SEBAGAI VARIABEL MEDIASI
Authors: Widyaningtyas Ambar Sari , Suharti Lieli
Published: February 2023

Penilaian kinerja adalah hasil atau tingkat keberhasilan seseorang selama periode tertentu dalam melaksanakan tugas. Sedangkan pemberian rating merupakan bagian dari evaluasi terhadap kinerja yang dicoba oleh karyawan. Penelitian ini bertujuan untuk mengetahui pengaruh sistem penilaian kinerja menggunakan rating bintang terhadap kinerja dengan disiplin kerja sebagai variabel mediasi pada driver gojek di Kabupaten Semarang. Penelitian ini menggunakan jenis dan desain penelitian kuantitatif. Teknik pengambilan sampel yang digunakan merupakan non probability sampling yaitu accidental sampling. Metode analisis data menggunakan regresi sederhana dan peran mediasi menggunakan uji sobel. Hasil penelitian membuktikan bahwa sistem penilaian kinerja dengan rating bintang berpengaruh positif  terhadap disiplin kerja driver, disiplin kerja dan sistem penilaian kinerja dengan rating bintang berpengaruh positif signifikan terhadap kinerja driver, dan disiplin kerja mampu memediasi pengaruh sistem penilaian kinerja dengan rating bintang terhadap kinerja.
¡Juguemos en el Antiguo Egipto! Flipped classroom a través del videojuego Assassin’s Creed: Origins
Authors: Vicent Naiara , Platas Mendaza Martin
Published: February 2023

En los últimos años se está intensificando la demanda de propuestas educativas que fomenten la adquisición de competencias. Teniendo en cuenta esta demanda, el uso habitual de videojuegos por parte de la juventud y la necesidad de un modelo que permita trabajar los contenidos de ciencias sociales que marca el curriculum escolar, se ha diseñado la siguiente propuesta didáctica. Esta combina el uso del videojuego Assassin's Creed: Origins con una metodología de aula invertida para el estudio del Antiguo Egipto en el primer curso de Educación Secundaria Obligatoria. El resultado, además de constatar que Assassin's Creed: Origins es una herramienta válida para el aprendizaje de la historia del Antiguo Egipto, ha permitido motivar al alumnado, convirtiéndole en protagonista de su propio aprendizaje.
valor de la historia. Estudio de alternativas curriculares en Secundaria (1): una visión integrada de las transformaciones (cambio/continuidad) que conducen y modelan el presente (conciencia histórica)
Authors: Paricio Royo Javier
Published: February 2023

Dar valor al estudio de la historia constituye el problema fundamental del diseño curricular. Partiendo de esta premisa, se proponen una serie de artículos en los que se plantean hipótesis curriculares alternativas para las asignaturas de historia en Secundaria y Bachillerato, frente al enfoque tradicional enciclopédico. Cada alternativa está centrada en un valor concreto, un logro valioso que configura y da sentido a una determinada orientación curricular. En esta primera entrega se propone un currículo orientado al desarrollo de la conciencia histórica, a través del estudio de los grandes procesos de transformación (técnica, económica, social, política, cultural, geopolítica…) a lo largo del tiempo. El estudiante aprende en este currículo a ver la historicidad del presente, como instantánea fugaz de un mundo en transformación constante, a valorar sus características como el resultado de esos procesos de transformación, y a analizar la complejidad de los procesos de cambio y continuidad que van conformando la realidad de cada momento histórico, incluido su presente.
Quantitative Structure-Activity relationship, Molecular Docking and ADMET Screening of Tetrahydroquinoline Derivatives as Anti-Small Cell Lung Cancer Agents
Authors: Erazua Ehimen Annastasia , Oyebamiji Abel Kolawole , Akintelu Sunday Adewale , Adewole Pelumi Daniel , Adelakun Adedayo , Adeleke Babatunde Benjamin
Published: February 2023

Lung carcinoma (LC) is responsible for almost one-third of all cancer fatalities worldwide. Tetrahydroquinoline is an organic molecule that is the semi-hydrogenated derivative of quinoline and could be found in several naturally occurring compounds such as flindersine, oricine etc. Some tetrahydroquinoline derivatives with pyrazole and hydrazide moieties were evaluated in silico against A549 (human lung cancer cell lines). The quantitative structural-activity relationship (QSAR) model created was statistically significant with validation metrics of R2 (0.9525), R2adj (0.9314), and CV.R (0.9719). The molecular docking analysis revealed that compound C14 demonstrated the best binding affinity towards the studied protein with binding affinity value of –10.1 kcal mol–1 (4LRM). This is in accordance with the experimental result (IC50 = 0.69). The factors observed for ADME&T correlated well with the factors observed for the referenced drug. This study indicates that compounds C1 and C9 can be further developed as anti-epidermal growth factor receptor (EGFR) compounds. Thus, our findings may open door for the design and development of library of efficient Tetrahydroquinoline-based drug-like compounds as potential anti-LC agents.
CHILDHOOD AND YOUTH OF JOURNALIST NATALIA LOGUNOVA. FROM MEMOIRS “THREE ERAS”
Authors:   Russian State University for the Humanities, Kiyanskaya Oksana I. ,   Institute of Scientific Information for Social Sciences of the Russian Academy of Sciences (INION RAN), Feldman David M. ,   Russian State University for the Humanities,   Institute of Scientific Information for Social Sciences of the Russian Academy of Sciences (INION RAN)
Published: February 2023

The article deals with the memoirs of Natalia Apollinarievna Ivanova, married Logunova (1903–1972), a Russian journalist and writer who emigrated to the United States in the 1940s. The author analyzes the first part of her memoirs from the Columbia University Archives, covering her childhood and adolescence in pre-revolutionary Odessa. It is about the family of the memoirist, her gymnasium years, the first literary experiences, attempts to publish her first works. In addition, the historical events of the early twentieth century, which Logunova reflects on, and their impact on the life of the memoirist and her loved ones, are analyzed.
THE PUBLICISTIC ASPECT OF THE STRUGGLE AGAINST RIGHT-WING BIAS IN PARTY POLITICS IN THE SATIRICAL MAGAZINE “CROCODILE” (1929)
Authors:   Russian State University for the Humanities, Iurganov Andrei L.
Published: February 2023

This article studies the interaction between Party power and the journal Crocodile in the struggle against right-wing bias in the Party. The interaction itself shows that Stalin’s ideological machine was struggling not only with the right-wing bias in the Party, but also in a broader sense – with all dissenters in Soviet society, with all those who did not share the transition from the new economic policy to military-communist methods of agricultural management, with those who were against the unleashing of a new civil war. The sketches of Crocodile magazine, which came out in huge circulations, provide a representative picture of the mental turn from the tolerance of the New Economic Policy Era to the intolerance of the new class struggle for the construction of socialism
Estágio de docência
Authors: Fortunato Ivan , Araújo Osmar Hélio Alves , Medeiros Emerson Augusto de
Published: February 2023

Neste artigo, apresentam-se três denúncias e anúncios para discutir a relação do estágio de docência nos programas de pós-graduação stricto sensu e a formação do professor-pesquisador para o Ensino Superior, quais sejam: (I) a dicotomia entre a formação para a pesquisa e a docência; (II) a dimensão solitária do estágio de docência; e (III) a falta da Pedagogia na formação de mestres e doutores. Ao final, espera-se promover reflexões sobre a formação do professor-pesquisador para o Ensino Superior.