bluuebunny/crossref_metadata_2025 huggingface dataset:
NEDDylated Cullin 3 mediates the adaptive response to topoisomerase 1 inhibitors
Authors: Meroni Alice , Grosser Jan , Agashe Sumedha , Ramakrishnan Natasha , Jackson Jessica , Verma Priyanka , Baranello Laura , Vindigni Alessandro
Published: December 2022

DNA topoisomerase 1 (TOP1) inhibitors are mainstays of anticancer therapy. These drugs trap TOP1 on DNA, stabilizing the TOP1-cleavage complex (TOP1-cc). The accumulation of TOP1-ccs perturbs DNA replication fork progression, leading to DNA breaks and cell death. By analyzing the genomic occupancy and activity of TOP1, we show that cells adapt to treatment with multiple doses of TOP1 inhibitor by promoting the degradation of TOP1-ccs, allowing cells to better tolerate subsequent doses of TOP1 inhibitor. The E3-RING Cullin 3 ligase in complex with the BTBD1 and BTBD2 adaptor proteins promotes TOP1-cc ubiquitination and subsequent proteasomal degradation. NEDDylation of Cullin 3 activates this pathway, and inhibition of protein NEDDylation or depletion of Cullin 3 sensitizes cancer cells to TOP1 inhibitors. Collectively, our data uncover a previously unidentified NEDD8–Cullin 3 pathway involved in the adaptive response to TOP1 inhibitors, which can be targeted to improve the efficacy of TOP1 drugs in cancer therapy.
Glia of
C. elegans
coordinate a protective organismal heat shock response independent of the neuronal thermosensory circuit
Authors: Gildea Holly K. , Frankino Phillip A. , Tronnes Sarah U. , Pender Corinne L. , Durieux Jenni , Dishart Julian G. , Choi Hyun Ok , Hunter Tayla D. , Cheung Shannon S. , Frakes Ashley E. , Sukarto Edward , Wickham Kevin , Dillin Andrew
Published: December 2022

Aging organisms lose the ability to induce stress responses, becoming vulnerable to protein toxicity and tissue damage. Neurons can signal to peripheral tissues to induce protective organelle-specific stress responses. Recent work shows that glia can independently induce such responses. Here, we show that overexpression of heat shock factor 1 (
hsf-1
) in the four astrocyte-like cephalic sheath cells of
Caenorhabditis elegans
induces a non–cell-autonomous cytosolic unfolded protein response, also known as the heat shock response (HSR). These animals have increased lifespan and heat stress resistance and decreased protein aggregation. Glial HSR regulation is independent of canonical thermosensory circuitry and known neurotransmitters but requires the small clear vesicle release protein UNC-13. HSF-1 and the FOXO transcription factor DAF-16 are partially required in peripheral tissues for non–cell-autonomous HSR, longevity, and thermotolerance. Cephalic sheath glial
hsf-1
overexpression also leads to pathogen resistance, suggesting a role for this signaling pathway in immune function.
Structural mechanism of extranucleosomal DNA readout by the INO80 complex
Authors: Kunert Franziska , Metzner Felix J. , Jung James , Höpfler Markus , Woike Stephan , Schall Kevin , Kostrewa Dirk , Moldt Manuela , Chen Jia-Xuan , Bantele Susanne , Pfander Boris , Eustermann Sebastian , Hopfner Karl-Peter
Published: December 2022

The nucleosomal landscape of chromatin depends on the concerted action of chromatin remodelers. The INO80 remodeler specifically places nucleosomes at the boundary of gene regulatory elements, which is proposed to be the result of an ATP-dependent nucleosome sliding activity that is regulated by extranucleosomal DNA features. Here, we use cryo–electron microscopy and functional assays to reveal how INO80 binds and is regulated by extranucleosomal DNA. Structures of the regulatory A-module bound to DNA clarify the mechanism of linker DNA binding. The A-module is connected to the motor unit via an HSA/post-HSA lever element to chemomechanically couple the motor and linker DNA sensing. Two notable sites of curved DNA recognition by coordinated action of the four actin/actin-related proteins and the motor suggest how sliding by INO80 can be regulated by extranucleosomal DNA features. Last, the structures clarify the recruitment of YY1/Ies4 subunits and reveal deep architectural similarities between the regulatory modules of INO80 and SWI/SNF complexes.
Outcome at early school age and adolescence after hypothermia-treated hypoxic–ischaemic encephalopathy: an observational, population-based study
Authors: Robertsson Grossmann Katarina , Eriksson Westblad Mimmi , Blennow Mats , Lindström Katarina
Published: December 2022

Objective

We aimed to describe long-term outcomes following hypoxic–ischaemic encephalopathy (HIE) treated with therapeutic hypothermia (TH).

Design

Prospective, population-based observational study.

Setting

Tertiary level neonatal intensive care units and neonatal outpatient clinic, Karolinska University Hospital, Stockholm, Sweden.

Patients

Sixty-six infants treated with TH due to HIE between 2007 and 2009.

Interventions

At 6–8 years and 10–12 years of age, children were assessed using a standardised neurological examination, the Movement Assessment Battery for Children, Second Edition (MABC-2) and the Wechsler Intelligence Scales for Children IV/V. Parents completed the Five-to-Fifteen (FTF) questionnaire.

Main outcome measures

Adverse outcome among survivors was defined as cerebral palsy (CP), epilepsy, hearing or visual impairment, full-scale IQ (FSIQ) below 85, attention deficit disorder with/without hyperactivity, autism spectrum disorder or developmental coordination disorder.

Results

Mortality was 12%. Seventeen per cent of survivors developed CP. Mean FSIQ was normal in children without major neuromotor impairment. Assessment in early adolescence revealed emerging deficits in 26% of children with a previously favourable outcome. The proportion of children exhibiting executive difficulties increased from 7% to 19%. This was reflected also by a significantly increased proportion of children with an FTF score >90th percentile compared with norms in early adolescence. The proportion of children with an MABC-2 score ≤5th percentile was also significantly increased compared with norms.

Conclusions

Survivors without major neuromotor impairment have normal intelligence. The incidence of executive difficulties appears to be increased in this patient population. More subtle difficulties may go undetected at early school-age.
Post COVID-19 irritable bowel syndrome
Authors: Marasco Giovanni , Cremon Cesare , Barbaro Maria Raffaella , Cacciari Giulia , Falangone Francesca , Kagramanova Anna , Bordin Dmitry , Drug Vasile , Miftode Egidia , Fusaroli Pietro , Mohamed Salem Youssef , Ricci Chiara , Bellini Massimo , Rahman Mohammed Masudur , Melcarne Luigi , Santos Javier , Lobo Beatriz , Bor Serhat , Yapali Suna , Akyol Deniz , Sapmaz Ferdane Pirincci , Urun Yonca Yilmaz , Eskazan Tugce , Celebi Altay , Kacmaz Huseyin , Ebik Berat , Binicier Hatice Cilem , Bugdayci Mehmet Sait , Yağcı Munkhtsetseg Banzragch , Pullukcu Husnu , Kaya Berrin Yalınbas , Tureyen Ali , Hatemi İbrahim , Koc Elif Sitre , Sirin Goktug , Calıskan Ali Riza , Bengi Goksel , Alıs Esra Ergun , Lukic Snezana , Trajkovska Meri , Hod Keren , Dumitrascu Dan , Pietrangelo Antonello , Corradini Elena , Simren Magnus , Sjölund Jessica , Tornkvist Navkiran , Ghoshal Uday C , Kolokolnikova Olga , Colecchia Antonio , Serra Jordi , Maconi Giovanni , De Giorgio Roberto , Danese Silvio , Portincasa Piero , Di Sabatino Antonio , Maggio Marcello , Philippou Elena , Lee Yeong Yeh , Salvi Daniele , Venturi Alessandro , Borghi Claudio , Zoli Marco , Gionchetti Paolo , Viale Pierluigi , Stanghellini Vincenzo , Barbara Giovanni
Published: December 2022

Objectives

The long-term consequences of COVID-19 infection on the gastrointestinal tract remain unclear. Here, we aimed to evaluate the prevalence of gastrointestinal symptoms and post-COVID-19 disorders of gut–brain interaction after hospitalisation for SARS-CoV-2 infection.

Design

GI-COVID-19 is a prospective, multicentre, controlled study. Patients with and without COVID-19 diagnosis were evaluated on hospital admission and after 1, 6 and 12 months post hospitalisation. Gastrointestinal symptoms, anxiety and depression were assessed using validated questionnaires.

Results

The study included 2183 hospitalised patients. The primary analysis included a total of 883 patients (614 patients with COVID-19 and 269 controls) due to the exclusion of patients with pre-existing gastrointestinal symptoms and/or surgery. At enrolment, gastrointestinal symptoms were more frequent among patients with COVID-19 than in the control group (59.3% vs 39.7%, p<0.001). At the 12-month follow-up, constipation and hard stools were significantly more prevalent in controls than in patients with COVID-19 (16% vs 9.6%, p=0.019 and 17.7% vs 10.9%, p=0.011, respectively). Compared with controls, patients with COVID-19 reported higher rates of irritable bowel syndrome (IBS) according to Rome IV criteria: 0.5% versus 3.2%, p=0.045. Factors significantly associated with IBS diagnosis included history of allergies, chronic intake of proton pump inhibitors and presence of dyspnoea. At the 6-month follow-up, the rate of patients with COVID-19 fulfilling the criteria for depression was higher than among controls.

Conclusion

Compared with controls, hospitalised patients with COVID-19 had fewer problems of constipation and hard stools at 12 months after acute infection. Patients with COVID-19 had significantly higher rates of IBS than controls.

Trial registration number

NCT04691895.
Loneliness at the age of COVID-19
Authors: Lederman Zohar
Published: December 2022

Loneliness has been a major concern for philosophers, poets and psychologists for centuries. In the past several decades, it has concerned clinicians and public health practitioners as well. The research on loneliness is urgent for several reasons. First, loneliness has been and still is extremely ubiquitous, potentially affecting people across multiple demographics and geographical areas. Second, it is philosophically intriguing, and its analysis delves into different branches of philosophy including phenomenology, existentialism, philosophy of mind, etc. Third, empirical research has shown that loneliness is a significant health risk factor. Loneliness may thus be defined as a (negative) social determinant of health.

Having that said, COVID-19 has demonstrated how little we as members of humanity have been prepared to face the loneliness resulting from the global response to the virus. As people worldwide are literally dying from loneliness, we still do not know what makes one feel lonely while making another feel being in solitude, or how is it that one feels lonely in the heart of London.

In this essay, I first review loneliness in general and specifically in the context of COVID-19. I then argue that loneliness should be understood as a social determinant of health. Lastly, I argue that individuals have a right not to be lonely. Such right stems in turn from the right to healthcare or even a right to health.
MTHFD2 suppresses glioblastoma progression via the inhibition of ERK1/2 phosphorylation
Authors: Huang Meihui , Xue Jiajian , Chen Zhiming , Zhou Xiao , Chen Mantong , Sun Jianhong , Xu Zhennan , Wang Shaohong , Xu Haixiong , Du Zepeng , Liu Mingfa
Published: December 2022

Glioblastoma (GBM) is a WHO grade 4 tumor and is the most malignant form of glioma. Methylenetetrahydrofolate dehydrogenase 2 (MTHFD2), a mitochondrial enzyme involved in folate metabolism, has been reported to be highly expressed in several human tumors. However, little is known about the role of MTHFD2 in GBM. In this study, we aimed to explore the biological functions of MTHFD2 in GBM and identify the associated mechanisms. We performed experiments such as immunohistochemistry, Western blot, and transwell assays and found that MTHFD2 expression was lower in high-grade glioma than in low-grade glioma. Furthermore, a high expression of MTHFD2 was associated with a favorable prognosis, and MTHFD2 levels showed good prognostic accuracy for glioma patients. The overexpression of MTHFD2 could inhibit the migration, invasion, and proliferation of GBM cells, whereas its knockdown induced the opposite effect. Mechanistically, our findings revealed that MTHFD2 suppressed GBM progression independent of its enzymatic activity, likely by inducing cytoskeletal remodeling through the regulation of extracellular signal-regulated kinase 1/2 (ERK1/2) phosphorylation, thereby influencing GBM malignance. Collectively, these findings uncover a potential tumor-suppressor role of MTHFD2 in GBM cells. MTHFD2 may act as a promising diagnostic and therapeutic target for GBM treatment.
Mechanistic approach to the antioxidant activities of metal-associated superoxide with Trolox
Authors: Singh Bula , Das Ranendu Sekhar
Published: December 2022

Trolox-C (TXC) is a water-soluble analogue of α-tocopherol that reduces the metal-bound superoxo complex (SOC), [(NH3)5Co(µ-O2)Co(NH3)5]5+in water–ethanol media. In aqueous-acid media ([H+] = 0.02–0.70 mol/L), TXC quantitatively reduces SOC under the pseudo first-order reaction condition where the concentration of TXC, [TXC], was at least 10 times or more than that of [SOC]. Variations in media ionic strength suggest for the reaction between two cationic species, and a positive kinetic isotope effect ( kH/ kD < 1) indicates for a pre-equilibrium step of protonation of the pyran-oxygen of TXC. Both TXC and the protonated TXC, i.e., TXCH, are the potential reductants under the experimental range of media acidity. The reduction of SOC takes place through the single-electron transfer and the kinetic analysis yields the value for second-order rate constants for TXC and TXCH as 9.7 and 3.6 × 103 (mol/L)−1s−1at 15 °C.
Ontogeny ofEuphanerops longaevusfrom the Upper Devonian Miguasha Fossil–Fish–Lagerstätte and comparison with the skeletogenesis of the sea lampreyPetromyzon marinus
Authors: Chevrinais Marion , Morel Catherine , Renaud Claude B. , Cloutier Richard
Published: December 2022

Ontogeny is of paramount importance to understand evolutionary relationships of organisms. However, in the fossil record, early developmental stages are rarely preserved because of their unmineralized skeleton. Here, we describe the ontogeny of the Devonian jawless fish, Euphanerops longaevus, based on observations from more than 3500 specimens. The ontogeny of Euphanerops is compared with the development of the median fins of the extant jawless fish, the sea lamprey ( Petromyzon marinus). From a subsample of 216 specimens of Euphanerops, we define three ontogenetic stages: larvae (2–38 mm total length (TL), mostly composed of “ Scaumenella mesacanthi”), juveniles (28–98 mm TL), and adults (≥90 mm TL) based on the degree of skeletal development, chemical and microscopic compositions. Larvae display three cranial plates, a simple branchial apparatus, notochordal elements, and caudal fin supports. In juveniles, we document the development of paired anteroventral, anal, and median dorsal fins. Given how little information is generally available on ostracoderm ontogeny, the growth series of Euphanerops provides an unparalleled opportunity to understand the development of early vertebrate characters.
$$^{74}$$Ge($$n,\gamma $$) cross section below 70 keV measured at n_TOF CERN
Authors: Lederer-Woods C. , Aberle O. , Andrzejewski J. , Audouin L. , Bécares V. , Bacak M. , Balibrea J. , Barbagallo M. , Barros S. , Battino U. , Bečvář F. , Beinrucker C. , Berthoumieux E. , Billowes J. , Bosnar D. , Brugger M. , Caamaño M. , Calviño F. , Calviani M. , Cano-Ott D. , Cardella R. , Casanovas A. , Castelluccio D. M. , Cerutti F. , Chen Y. H. , Chiaveri E. , Colonna N. , Cortés G. , Cortés-Giraldo M. A. , Cosentino L. , Damone L. A. , Diakaki M. , Domingo-Pardo C. , Dressler R. , Dupont E. , Durán I. , Fernández-Domínguez B. , Ferrari A. , Ferreira P. , Finocchiaro P. , Furman V. , Göbel K. , García A. R. , Gawlik-Ramięga A. , Glodariu T. , Gonçalves I. F. , González-Romero E. , Goverdovski A. , Griesmayer E. , Guerrero C. , Gunsing F. , Harada H. , Heftrich T. , Heinitz S. , Heyse J. , Jenkins D. G. , Jericha E. , Käppeler F. , Kadi Y. , Katabuchi T. , Kavrigin P. , Ketlerov V. , Khryachkov V. , Kimura A. , Kivel N. , Kokkoris M. , Krtička M. , Leal-Cidoncha E. , Leeb H. , Lerendegui-Marco J. , Meo S. Lo , Lonsdale S. J. , Losito R. , Macina D. , Marganiec J. , Martínez T. , Massimi C. , Mastinu P. , Mastromarco M. , Matteucci F. , Maugeri E. A. , Mendoza E. , Mengoni A. , Milazzo P. M. , Mingrone F. , Mirea M. , Montesano S. , Musumarra A. , Nolte R. , Oprea A. , Patronis N. , Pavlik A. , Perkowski J. , Porras I. , Praena J. , Quesada J. M. , Rajeev K. , Rauscher T. , Reifarth R. , Riego-Perez A. , Rout P. C. , Rubbia C. , Ryan J. A. , Sabaté-Gilarte M. , Saxena A. , Schillebeeckx P. , Schmidt S. , Schumann D. , Sedyshev P. , Smith A. G. , Stamatopoulos A. , Tagliente G. , Tain J. L. , Tarifeño-Saldivia A. , Tassan-Got L. , Tsinganis A. , Valenta S. , Vannini G. , Variale V. , Vaz P. , Ventura A. , Vlachoudis V. , Vlastou R. , Wallner A. , Warren S. , Weigand M. , Weiss C. , Wolf C. , Woods P. J. , Wright T. , Žugec P. ,   n_TOF Collaboration
Published: December 2022

Neutron capture reaction cross sections on$$^{74}$$74Ge are of importance to determine$$^{74}$$74Ge production during the astrophysical slow neutron capture process. We present new resonance data on$$^{74}$$74Ge($$n,\gamma $$n,γ) reactions below 70 keV neutron energy. We calculate Maxwellian averaged cross sections, combining our data below 70 keV with evaluated cross sections at higher neutron energies. Our stellar cross sections are in agreement with a previous activation measurement performed at Forschungszentrum Karlsruhe by Marganiec et al., once their data has been re-normalised to account for an update in the reference cross section used in that experiment.
Tetraquark mixing supported by the partial decay widths of two light-meson nonets
Authors: Kim Hungchong , Kim K. S.
Published: December 2022

Recently, the tetraquark mixing framework has been proposed as a possible structure for the two light-meson nonets in the $$J^P=0^+$$

J
P

=

0
+

channel, the light nonet composed of $$a_0(980)$$

a
0

(
980
)

, $$K_0^*(700)$$

K
0
∗

(
700
)

, $$f_0(500)$$

f
0

(
500
)

, $$f_0(980)$$

f
0

(
980
)

, and the heavy nonet of $$a_0(1450)$$

a
0

(
1450
)

, $$K_0^*(1430)$$

K
0
∗

(
1430
)

, $$f_0(1370)$$

f
0

(
1370
)

, $$f_0(1500)$$

f
0

(
1500
)

. Among various signatures, we report in this work that their partial decay widths collected from various experimental data in Particle Data Group (PDG) can support this mixing scheme also. In particular, we demonstrate that the couplings of the light nonet to two pseudoscalar mesons estimated from the partial widths are consistently stronger than those of the heavy nonet. This consistent feature agrees qualitatively well with the predictions from the tetraquark mixing framework and, therefore, provides supporting evidence for the tetraquark mixing.
Electrical Analysis and Comparison of Ta2O5 Tunneling Oxide with SiO2 in Passivated c-Si Solar Cell
Authors: Verma Manish , Mishra Guru Prasad
Published: December 2022

The Tantalum oxide material (Ta2O5) as tunnel oxide in comparison with the Silicon dioxide (SiO2) Tunnel oxide is proposed. The lower bandgap and high refractive index of Ta2O5 has several advantages over SiO2. The Ta2O5 is used as Anti-Reflecting coating earlier, but also has capability to behave as the tunneling oxide. In the ultrathin region, the Tantalum oxide (Ta2O5) potentially produces extremely high tunneling and high electric field. The greater electrical intensity increases both the transportation of carrier and passivation quality of designed c-Si structure. The carrier selectivity is also increased due to very high capacitive nature. The performance measurement is done in ASTM certified AM1.5G environment using Silvaco ATLAS 2D TCAD tool. The comparison has been made between Ta2O5 and SiO2, to show the advantage of Ta2O5 over SiO2. The lower bandgap of 4.8eV and higher affinity of 3.19 of Ta2O5 as compared to SiO2 proves to be better material as tunneling oxide. The bandgap and electric field region of both the materials have been studied. In first approach to use Ta2O5 as tunneling oxide, the power conversion 28.42% is obtained for 0.1nm thickness of the Ta2O5. External and internal quantum efficiencies are well above 80% and 90% respectively. The characteristics of the Ta2O5 tunneling based solar cell are compared with the previous reported solar cell.
Cylindrical SOI Schottky Barrier MOSFET with High Linearity and Low Static Power for Digital and Analog Circuits Application
Authors: Saxena Amit , Kumar Manoj , Sharma R. K. , Gupta R. S.
Published: December 2022

Non-linearity and static power consumption are major challenges in the designing of digital and analog circuits. To improve the performance of digital and analog circuits, a proper selection of MOSFET device architecture is essential. The MOSFET device architecture with low static power dissipation and high linearity results in improves overall performance at the circuit level. In this work, a detailed analysis of cylindrical Silicon-on-Insulator (SOI) Schottky Barrier (SB) MOSFET is done for analog and digital circuit applications. The analog device parameters and device non-linearity parameters for SOI SB MOSFET are extracted and compared with SB MOSFET and Dielectric Pocket (DP) SB MOSFET. The SOI SB MOSFET shows an improvement of 6.905% in output conductance (gds), 130.513% in early voltage (Vea), 240.74% in transconductance generation factor (TGF), 35.901% in transconductance frequency product (TFP), 23.529% in the gain-bandwidth product (GBWP), 25.542% in voltage gain (Av), 130.968% in gain frequency product (GFP), and 179.964% in gain transconductance frequency product (GTFP). Third-order extrapolated voltage (VIP3), third-order extrapolated power (IIP3), and extrapolated intermodulation power (IMD3) have also improved in comparison to SB MOSFET. The Atlas 3-D device simulation tool is used for numerical simulations.
Investigation of Structural Parameters Impact on Sensitivity of InP/InGaAs/InP Channel Double Gate MOSFET for Biosensing Application
Authors: Mohanty Soumya S. , Mishra Sikha , Mohapatra Meryleen , Mishra Guru Prasad
Published: December 2022

A simulation-based study of sensitivity parameters of hetero (InP/InGaAs/InP) channel with source-side cavity double gate MOSFET (H-SCDG MOSFET) to detect the label-free biomolecules like uricase (K=1.54), streptavidin (K=2.10), ferrocytochrome C (K=4.7), and protein (K=8) has been done. A nanogap cavity is embedded beneath the gate oxide segment to trap the bio-targets, which gives the deviation in threshold voltage. By incorporating the dielectric modulation method, the sensitivity analysis has been done with the variation in structural parameters of the device. The impact of sensitivity with a variation of cavity length (Lcavity) and oxide thickness (tox) is also examined. The ample performance of H-SCDG MOSFET has been extensively studied by using the 2D TCAD platform. It is observed that the protein biomolecule shows the value of sensitivity, on current sensitivity and subthreshold swing sensitivity as 0.53, 1.75, and 0.96, respectively, with Lcavity=15nm and tox=1nm.
Process Induced Stress Optimization for Compressively Stressed p-Channel FinFET at 7N
Authors: Jena J. , Dash T. P. , Mohapatra E. , Das S. , Nanda J.
Published: December 2022

At 7nm technology node, the trigate FinFETs are the promising candidates for modern integrated circuits. Their optimal design and improved performance are key demands for most of the leading semiconductor manufacturing industries. This work proposes an improvement of electrical performance through process induced stress optimization for a compressively stressed FinFET at a 7nm Technology node. The variation of two design parameters (fin angle and epi angle) can lead to a change in stress and hence the devices’ electrical performance, which is the major focus of this study. A process induced compressively stressed p-channel FinFET at 7nm Technology node is virtually fabricated using Technology CAD (TCAD) by introducing a SiGe epitaxial layer at Source and Drain regions. The variation of electrical performances with change in epi angle (θEpi) and fin angle (θFin) is critically analyzed. These results predict the improvement of the drive current and reduction in short channel effect with the appropriate selection of the θFin and θEpi. Hence, the predictive TCAD simulations explored the new avenues of strain-engineered FinFET for future CMOS technology generations.
ℤ2-gradings and minimal varieties of ℤ2-graded PI algebras
Authors: Avelar Danilo Vilela , da Silva Viviane Ribeiro Tomaz
Published: December 2022

Let [Formula: see text] be an algebraically closed field of characteristic zero and let [Formula: see text] be a minimal superalgebra with semisimple part [Formula: see text], where each [Formula: see text] is a simple superalgebra. We say that [Formula: see text] is [Formula: see text]-special if [Formula: see text] and there exists [Formula: see text] such that [Formula: see text], with [Formula: see text], whereas, for the remaining indices [Formula: see text], [Formula: see text]. In [1], Avelar et al. classified the [Formula: see text]-special minimal superalgebras and described some necessary and sufficient conditions for the varieties generated by such superalgebras to be minimal of [Formula: see text]-exponent [Formula: see text]. In this paper, we give continuity to a such study and we made explicit that the [Formula: see text]-gradings play an important role in the minimality of some varieties. We provide sufficient conditions, depending on the [Formula: see text]-grading of [Formula: see text], for the variety generated by [Formula: see text] to be minimal. Moreover, we characterize two families of [Formula: see text]-special minimal superalgebras and we give necessary and sufficient conditions (depending on their [Formula: see text]-gradings) for the varieties generated by them to be minimal.
Extraction of Technical Indicators and Data Augmentation-Based Stock Market Prediction Using Deep LSTM Integrated Competitive Swarm Feedback Algorithm
Authors: Yadav Vanguri Nagarjun , Pazhanirajan S. , Anil Kumar T.
Published: December 2022

In recent decades, time-series analysis and value forecasting have grown in research fields. Making a significant decision in the stock market prediction strategy requires knowledge that may be gained by forecasting with time-series data. Various prediction methods are developed to forecast future stock prices, but accurate prediction with the time-series data using external factors still results in a difficult task. An effective prediction approach is designed in this paper using the adopted Competitive Swarm Feedback Algorithm-based Deep Long Short-Term Memory (CSFA-based Deep LSTM) classifier for predicting the stock market data. The CSFA is the integration of the Competitive Swarm Optimizer (CSO) and Feedback Artificial Tree (FAT) algorithm. Then, technical indicators’ extraction, feature fusion and data augmentation steps are carried out. The Deep LSTM achieved higher prediction results than the other traditional classifiers. The proposed method achieved lower MAE, lower MSE, and minimum RMSE with the values of 0.1418, 0.1119, and 0.2557.
Production Planning Games in Uncertain Environment
Authors: Bigdeli Hamid , Tayyebi J. , Hassanpour H.
Published: December 2022

In this paper, a production planning game with single and multiobjectives in uncertain environment is considered. In this problem, the parameters are assumed to be fuzzy variables. By the notions of the expected value and the critical value, the concept of the solutions in the game is introduced. It is shown that the game is balanced and the core of game is nonempty. The duality theory in single-objective and the weighted sum method in multiobjective games are proposed to obtain the payoffs of the players. Finally, the validity and applicability of the method are illustrated by a practical example.
The matrix splitting fixed point iterative algorithms for solving absolute value equations
Authors: Ali Rashid , Ali Asad
Published: December 2022

This paper describes two new iterative algorithms for determining absolute value equations. The algorithms are based on a splitting of the coefficient matrix. Moreover, we analyze the convergence effects of the presented algorithms via some theorems. Eventually, numerical tests are provided to confirm the credibility of our procedures.
Tuneman: Customizing Networks to Guarantee Application Bandwidth and Latency
Authors: Sharma Sidharth , Kushwaha Aniruddha , Alizadeh Mohammad , Varghese George , Gumaste Ashwin
Published: December 2022

We examine how to provide applications with dedicated bandwidth and guaranteed latency in a programmable mission-critical network. Unlike other SDN approaches such as B4 or SWAN, our system Tuneman optimizes
both
routes and packet schedules at each node to provide flows with sub-second bandwidth changes. Tuneman uses node-level optimization to compute node schedules in a slotted switch and does dynamic routing using a search procedure with Quality of Service– (QoS) based weights. This allows Tuneman to provide an efficient solution for mission-critical networks that have stringent QoS requirements. We evaluate Tuneman on a telesurgery network using a switch prototype built using FPGAs and also via simulations on India’s Tata Network. For mission-critical networks with multiple QoS levels, Tuneman has comparable or better utilization than SWAN while providing delay bounds guarantees.
Supernatural Attributions: Seeing God, the Devil, Demons, Spirits, Fate, and Karma as Causes of Events
Authors: Exline Julie J. , Wilt Joshua A.
Published: December 2022

For many people worldwide, supernatural beliefs and attributions—those focused on God, the devil, demons, spirits, an afterlife, karma, or fate—are part of everyday life. Although not widely studied in clinical psychology, these beliefs and attributions are a key part of human diversity. This article provides a broad overview of research on supernatural beliefs and attributions with special attention to their psychological relevance: They can serve as coping resources, sources of distress, psychopathology signals, moral guides, and decision-making tools. Although supernatural attributions sometimes involve dramatic experiences seen to violate natural laws, people more commonly think of supernatural entities working indirectly through natural events. A whole host of factors can lead people to make supernatural attributions, including contextual factors, specific beliefs, psychopathology, cognitive styles and personality, and social and cultural influences. Our aim is to provide clinical psychologists with an entry point into this rich, fascinating, and often overlooked literature.
Coaxial Stub-Loaded Resonators Based Dual-Band High Power Bandpass Filter and Diplexer
Authors: Arslan Muhammad
Published: December 2022

Design and simulation of a dual-band cavity filter (Coaxial based) and the diplexer with the advanced topology of stub-loaded resonators (SLRs) have been presented in this paper. By adjusting the structural parameters, the frequency of resonance can be tuned to the proposed model of a coaxial stub-loaded resonator (SLR). External quality factors for both passbands (lower and upper) can be achieved by using different combinations of horizontal and vertical metallic cylinders enclosed in a cavity of fixed size. A coupling pin and window have been implemented to achieve desired coupling coefficients for both lower and upper passbands. To validate the idea, a bandpass filter having two resonating bands of 3rd order and a diplexer having eight poles is designed. Simulation is performed in the CST design studio. The full-wave simulation results are fulfilling the design requirements.
Modeling incomplete penetrance in long QT syndrome type 3 through ion channel heterogeneity: an in silico population study
Authors: Miller Jacob A. , Moise Nicolae , Weinberg Seth H.
Published: December 2022

An in silico population approach investigates the relationship between variability in ion channel expression and gain-of-function mutations in the voltage-gated sodium channel associated with the congenital disorder long QT syndrome type 3 (LQT3). We find that ion channel variability can contribute to incomplete penetrance of the mutation, with mutant-specific differences in ion channel conductances leading to susceptibility to proarrhythmic action potential duration prolongation or early afterdepolarizations.
The effect of sex and age on ex vivo cardiac electrophysiology: insight from a guinea pig model
Authors: Haq Kazi T. , Cooper Blake L. , Berk Fiona , Posnack Nikki Gillum
Published: December 2022

We evaluated whether the guinea pig heart has intrinsic sex-specific differences in cardiac electrophysiology. Although we observed sex-specific differences in in vivo ECGs, these differences did not persist ex vivo. Using a whole heart model, we observed similar APD, CaD, conduction velocity, and alternans susceptibility in males and females. We conclude that sex-specific differences in guinea pig cardiac electrophysiology are likely influenced by the in vivo environment and less dependent on the intrinsic electrical properties of the heart.
The Relationship between Fear of COVID-19 and Self-Medication and the Rate of Antibiotic Use in Patients Referred to COVID-19
Authors: Faraji Fatemeh , Jalali Rostam , Salari Nader
Published: December 2022

Introduction. The coronavirus pandemic can cause anxiety and stress among people, which can make them practice self-medication. This study aimed to investigate the relationship between fear of corona and self-medication and antibiotics use. Methods. In a convenience sampling method, 250 people referring to COVID-19 centers including 16-hour comprehensive health services in Kermanshah, Iran, who tested positive and were not hospitalized were extracted from the SIB system. Data collection tools include three questionnaires including corona fear questionnaire, self-medication questionnaire, and self-medication by antibiotic questionnaire and an information form including demographic characteristics. Data were analyzed by SPSS version 25. Results. The prevalence of self-medication was 59.6%. There was a significant correlation between self-medication and gender (

P

value <0.05) and education level (

P

value <0.05); the most common reason for self-medication was easy access to medicines through pharmacy drug stores. The mean score of fear of corona was higher in women and those who were not in a good financial position due to a lack of suitable economic status to see a doctor. Conclusion. There was a direct and significant relationship between self-medication and self-medication by antibiotics. 59.6% of the participants used medicines themselves, buying over-the-counter in pharmacies. Also, there was a statistically significant difference between the mean score of corona fear in terms of not having a suitable economic status to see a doctor. This indicates that the lack of proper economic status among people with the coronavirus positive test to see a doctor increases the fear of the disease.
Surface Characteristics of Electrospun p-Sulphonated Calix[4]Arene Functionalized Cellulose Acetate Nanofiber and Its Behaviour towards Methylene Blue Adsorption
Authors: Basri Nur Amilah Fadlina , Wahid Mohd Haniff , Zainal Zulkarnain , Ahmad Shahrul Ainliah Alang , Manap Mohd Rashidi Abdull
Published: December 2022

p-sulphonated calix[4]arene ( p-SOCX) functionalized cellulose acetate/graphene oxide (CA/GO) nanofibers were successfully prepared via the electrospinning technique. The presence of p-SOCX within the fiber matrix was ascertained using Fourier Transform Infrared spectroscopy and Carbon-Hydrogen-Nitrogen-Sulphur elemental analyses. Apparent changes in morphology of the samples were observed under scanning electron microscope where fiber diameters increased with increasing p-SOCX content. Preliminary dye removal test at different pH, dosage, and temperature of functionalized CA/GO nanofiber demonstrates enhanced adsorption capacity of methylene blue in presence of p-SOCX compared to pristine CA nanofiber and CA/GO nanofiber at an optimum pH 8. The highest removal efficiency obtained was 88.84% with initial methylene blue dye concentration of 10 mg/L, adsorbent dosage of 20 mg/10 mL, contact time of 30 min at room temperature ca. 293 K.
Rural-Urban Determinants of Receiving Skilled Birth Attendants among Women in Bangladesh: Evidence from National Survey 2017-18
Authors: Afroja Sohani , Muhammad Nasim Abu Saleh , Khan Md. Salauddin , Kabir Mohammad Alamgir
Published: December 2022

Background. SBAs (skilled birth attendants) play a crucial role in reducing maternal mortality. The proportion of maternal healthcare in Bangladesh that receives quality care at birth has increased; the reasons for this are unknown. The purpose of this study is to see if there has been a change in the use of specific maternal healthcare indicators in urban and rural areas, as well as significant risk factors. Materials and Methods. The data set was extracted from a nationally representative survey based on a cross-sectional study, the Bangladesh Health and Demographic Survey (BDHS) 2017-18. The frequency distribution reveals the general state of SBAs. To identify the association, we performed the chi-square test. Finally, multiple logistic regression was used to analyse the factors associated with SBAs and determine the degree of SBAs disparity between urban and rural areas. Results. In Bangladesh, 53% of women received SBAs during childbirth, with urban and rural areas receiving 68.1 and 52.2 percent, respectively. Women with secondary (AOR: 1.79, CI: 1.05–3.08) and higher (AOR: 4.18, CI: 2.09–8.50) education were more likely to receive SBAs than women in urban areas who were illiterate. Husband’s education, women’s working status, wealth index, children’s birth order, and number of ANC visit are significant factors in receiving SBSs in both urban and rural areas. Higher educated husbands are 1.83 times (AOR = 1.83, CI: 1.04–3.25, p = 0.037) and 1.82 times (AOR = 1.82, CI: 1.29–2.59, p = 0.001) more likely to attend skilled births than uneducated husbands in both urban and rural areas. Respondents from the richest families are more likely to attend skilled births than those from the poorest families in both urban and rural areas. Conclusion. During delivery, significant risk factors are substantially related to SBAs. More attention must be given to rural and illiterate populations, who are less likely to obtain these services, to minimize maternal and neonatal mortality. Special programs could be developed to raise awareness and facilitate the poor in receiving the basic necessities of maternal care.
Mixed Convection Heat Transfer of a Hybrid Nanofluid in a Trapezoidal Prism with an Adiabatic Circular Cylinder
Authors: Hirpho Mohammed , Ibrahim Wubshet
Published: December 2022

This communication presents the mixed convection flow of hybrid nanofluid flow in a trapezoidal prism cavity. The cavity contains an adiabatic circular cylinder filled with

A
g
−
M
g
O

water hybrid nanofluid. The top surface of a prism cavity is heated to a uniform temperature of

T

h

, and the bottom surface of the prism is cooled to a temperature of

T

c

. The other surfaces of a prism are thermally insulated. The equations governing the flow problem are obtained using conservation principles and nondimensionalized with the help of nondimensional variables. Then, with the help of the Galerkin finite element method algorithm embedded in COMSOL Multiphysics® software, the numerical simulation was performed. The streamlines and isotherms on the surfaces of the cavity have been plotted and thoroughly discussed. The results reveal that buoyant convection distorts the isothermal fields as the Richardson number increases, so does fluid flow penetration in the cavity. The results also reveal that as the Richardson number and volume fraction of hybrid nanoparticles increase, the average Nusselt number diminishes.
Air Quality Prediction Using the Fractional Gradient-Based Recurrent Neural Network
Authors: Arora Sugandha , Sawaran Singh Narinderjit Singh , Singh Divyanshu , Rakesh Shrivastava Rishi , Mathur Trilok , Tiwari Kamlesh , Agarwal Shivi
Published: December 2022

In this study, the air quality index (AQI) of Indian cities of different tiers is predicted by using the vanilla recurrent neural network (RNN). AQI is used to measure the air quality of any region which is calculated on the basis of the concentration of ground-level ozone, particle pollution, carbon monoxide, and sulphur dioxide in air. Thus, the present air quality of an area is dependent on current weather conditions, vehicle traffic in that area, or anything that increases air pollution. Also, the current air quality is dependent on the climate conditions and industrialization in that area. Thus, the AQI is history-dependent. To capture this dependency, the memory property of fractional derivatives is exploited in this algorithm and the fractional gradient descent algorithm involving Caputo’s derivative has been used in the backpropagation algorithm for training of the RNN. Due to the availability of a large amount of data and high computation support, deep neural networks are capable of giving state-of-the-art results in the time series prediction. But, in this study, the basic vanilla RNN has been chosen to check the effectiveness of fractional derivatives. The AQI and gases affecting AQI prediction results for different cities show that the proposed algorithm leads to higher accuracy. It has been observed that the results of the vanilla RNN with fractional derivatives are comparable to long short-term memory (LSTM).
Tumor-Infiltrating Lymphocyte Therapy in Melanoma: Facts to the Future
Authors: Betof Warner Allison , Corrie Pippa G. , Hamid Omid
Published: December 2022

Adoptive cell therapy with tumor-infiltrating lymphocytes (TIL) is gaining momentum and demonstrating durable responses in patients with advanced melanoma. Although increasingly considered as a treatment option for select patients with melanoma, TIL therapy is not yet approved by any regulatory agency. Pioneering studies with first-generation TIL therapy, undertaken before the advent of modern melanoma therapeutics, demonstrated clinical efficacy and remarkable long-term overall survival, reaching beyond 20 months for responding patients. TIL therapy is a multistep process of harvesting patient-specific tumor-resident T cells from tumors, ex vivo T-cell expansion, and re-infusion into the same patient after a lymphodepleting preparative regimen, with subsequent supportive IL2 administration. Objective response rates between 30% and 50% have consistently been observed in heavily pretreated patients with metastatic melanoma, including those who have progressed after modern immune checkpoint inhibitors and BRAF targeted agents, a population with high unmet medical need. Although significant strides have been made in modern TIL therapeutics, refinement strategies to optimize patient selection, enhance TIL production, and improve efficacy are being explored. Here, we review past and present experience, current challenges, practical considerations, and future aspirations in the evolution of TIL therapy for the treatment of melanoma as well as other solid tumors.
FDA Approval Summary: Ripretinib for Advanced Gastrointestinal Stromal Tumor
Authors: Kumar Vaibhav , Doros Leslie , Thompson Margaret , Mushti Sirisha L. , Charlab Rosane , Spehalski Elizabeth I. , Zhao Hong , Thompson Matthew D. , Tang Shenghui , Pazdur Richard , Lemery Steven J. , Theoret Marc R. , Fashoyin-Aje Lola A.
Published: December 2022

On May 15, 2020, the FDA approved ripretinib for adult patients with advanced gastrointestinal stromal tumor who have received prior treatment with three or more kinase inhibitors, including imatinib. The approval was based on results from INVICTUS (NCT03353753), an international, multi-center, double-blind, placebo-controlled trial. Patients were randomly allocated (2:1) to receive either ripretinib 150 mg once daily (n = 85) or matching placebo (n = 44). The trial demonstrated a statistically significant improvement in progression-free survival (PFS) as assessed by modified RECIST v1.1 by blinded independent central review for patients randomized to ripretinib, with a median PFS of 6.3 months [95% confidence interval (CI): 4.6–6.9] compared with 1.0 month (95% CI: 0.9–1.7) for placebo [HR: 0.15 (95% CI: 0.09–0.25); P < 0.0001, stratified log-rank test]. There was no statistically significant difference in objective response rate in the ripretinib arm, 9% (95% CI: 4.2–18) compared with placebo 0% [(95% CI: 0–8); P = 0.0504, Fisher exact test]. The median overall survival (OS) in the ripretinib arm was 15.1 months (95% CI: 12.3–15.1) compared with 6.6 months (95% CI: 4.1–11.6) in the placebo arm. A formal statistical comparison of OS was not made due to the prespecified hierarchical analysis plan. The most common (≥20%) adverse events with ripretinib, in order of decreasing frequency, were alopecia, fatigue, nausea, abdominal pain, constipation, myalgia, diarrhea, decreased appetite, palmar-plantar erythrodysesthesia, and vomiting. Other important risks of ripretinib include new primary cutaneous malignancies, hypertension, and cardiac dysfunction.
Epitope-Specific IgE at 1 Year of Age Can Predict Peanut Allergy Status at 5 Years
Authors: Grinek Stepan , Suprun Maria , Raghunathan Rohit , Tomalin Lewis E. , Getts Robert , Bahnson Tee , Lack Gideon , Sampson Hugh A. , Suarez-Farinas Mayte
Published: December 2022

Background: Currently, there is no laboratory test that can accurately identify children at risk of developing peanut allergy. Utilizing a subset of children randomized to the peanut avoidance arm of the LEAP trial, we monitored the development of epitope-specific (ses-)IgE and ses-IgG4 from 4–11 months to 5 years of age. Objective: The aim of the study was to evaluate the prognostic ability of epitope-specific antibodies to predict the result of an oral food challenge (OFC) at 5 years. Methods: A Bead-Based Epitope Assay was used to quantitate IgE and IgG4 to 64 sequential (linear) epitopes from Ara h 1–3 proteins at 4–11 months, 1 and 2.5 years of age in 74 subjects (38 of them with a positive OFC at 5 years). Specific IgE (sIgE) to peanut and component proteins was measured using ImmunoCAP. Machine learning methods were used to identify the earliest time point to predict 5-year outcome, developing prognostic algorithms based only on 4–11 month samples, 1-year or 2.5-year, and a combination of them. Data from 74 children were iteratively split 3:1 into training and validation sets, and machine learning models were developed to predict the 5-year outcome. A test set (n = 90) from an independent cohort was used for final evaluation. Results: Elastic-Net algorithm combining ses-IgE and IgE to Ara h 1, 2, 3, and 9 proteins could predict the 5-year peanut allergy status of LEAP participants with an average validation accuracy of 64% at baseline. Samples taken at 1 year accurately predicted a 5-year OFC outcome with 83% accuracy. This performance remained consistent when evaluated on an independent CoFAR2 cohort with an accuracy of 78% for the 1-year model. Conclusion: IgE antibody profiles at 1 year of age are predictive of peanut OFC at 5 years in children avoiding peanuts. If further confirmed, this model may enable early identification of infants who may benefit from early immunotherapeutic interventions.