bluuebunny/crossref_metadata_2025 huggingface dataset:
Strategies for adopting disruptive technology among universities during the COVID-19 pandemic.
Authors: collince odero , Allen Robert
Published: June 2021

The study adopted qualitative approach to
explore the strategies used by universities based on experience of the key
informants when adopting eLearning as a disruptive technology during the
COVID-19 pandemic. The sample size was 10 interviewees, five (three faculty and two ICT
personnel) from each of the two universities. Analysis of their demographic
profile indicates a diverse age group ranging between 30 years and 50 years. It
was required that these participants must have unique experiences, perceptions,
attitudes and characteristics concerning the eLearning adoption strategies in
universities.
RNAs hold a lot of potential when it comes to druggable molecular targets
Authors: Dowaidar Moataz
Published: June 2021

Small molecules drugged just about 700 molecular targets. Most of these molecular targets are proteins, representing 0.5% of the proteome and 0.05% of the genome. It has also been proven that whereas 90% of human genes are transcribed into RNAs, only 2% are translated into proteins. Non-coding RNAs are transcribed from around 70% of human genes. As a result, RNAs hold a lot of potential when it comes to druggable molecular targets, yet they've long been regarded as intractable.MiRNAs are a sort of non-coding RNA that finely regulates gene expression in human cells and has been connected to the development of diseases such as cancer. Using small compounds to drug miRNAs is a distinct and promising strategy, while miRNAs have long been recognized as drug targets and ASOs that block miRNAs have been used in clinical studies. In the past, small drugs targeting alternative biomolecules to indirectly influence miRNAs have been found, but small compounds directly targeting miRNAs offer more potential as therapeutic possibilities. This review summarized recently found chemicals that might directly target miRNAs. When these small molecules connect to miRNAs, they either block or degrade miRNA. These small molecules have also been shown to be beneficial in cancer therapy.In the future, several challenges must be solved to boost the potency of small molecules in drug miRNAs. For starters, discovering a strongly specific miRNA SMI is crucial for medicinal development. While the strategies previously released have shown promise in discovering SMIs, new effective strategies must be created or existing approaches must be enhanced. Second, biotechnologies like gene sequencing and pull-down methods should be combined to test and boost the specificity of identified SMIs. Third, new small-molecule functionalities that can more efficiently degrade RNAs are needed to generate SMDs that work as miRNA degraders. Fourth, most SMIs and SMDs' on-target and off-target toxicity was not adequately examined. This requires detailed bio-safety analyses of manufactured SMIs and SMDs.Finally, a brief summary of small drugs that can directly target miRNAs. MiRNA inhibition and cancer therapy revealed both the efficacy and selectivity of these small molecules. Hopefully, these and other future small molecules will open the door for therapy development that targets druggable miRNAs.
Exosomes' function in cardiovascular protection and neovascularization implies that they might be used to treat ischemia and atherosclerotic cardiovascular diseases
Authors: Dowaidar Moataz
Published: June 2021

Myocardial hypertrophy, injury and infarction, ventricular remodeling, angiogenesis, and atherosclerosis are all influenced by cardiac exosome proteins and miRNAs, which mediate cell-to-cell communication, stimulate or inhibit target cell activities, and have an impact on myocardial hypertrophy, injury and infarction, ventricular remodeling, angiogenesis, and atherosclerosis. Circulating cardiac-specific exosome microRNAs show potential as biomarkers for early identification of acute myocardial infarction and as prognostic indicators for ischemic cardiomyopathy and congestive heart failure progression. Exosomes' function in cardiovascular protection and neovascularization implies that they might be used to treat ischemia and atherosclerotic cardiovascular diseases. Because of their biocompatibility, circulatory stability, biological barrier penetration, limited immunogenicity, and low toxicity, exosomes have the potential to deliver therapeutic pharmacologic compounds.A greater understanding of exosome composition and activity will facilitate the development of novel therapeutic alternatives for the treatment of patients with atherosclerotic cardiovascular diseases.
Many miRNAs participate in inflammatory regulation and bone metabolism. Overexpression of miR21 and miR155 releases proinflammatory cytokines
Authors: Dowaidar Moataz
Published: June 2021

A variety of miRNAs involved in inflammatory regulation and bone metabolism impact the clinical course of periodontitis and periimplantitis. The expression levels of the miR146 family, the let7 family, and miR1445p are all raised in periodontal lesions, resulting in accelerated tissue deterioration via the TLR, NFB, and other signaling pathways. Overexpression of miR21 and miR155 induces the release of proinflammatory cytokines. The lack of MiR21 induces significant periodontal bone loss, although cutting down miR155 reduces TNF-induced osteogenesis inhibition to some extent. MiR223, miR27a, and miR128 are all associated with bone remodeling. In periimplantitis, the expression of miR27a and miR128 is downregulated, which might be connected to alveolar bone resorption. To far, only a few studies have been conducted on inflammatory alveolar bone defects and related microRNAs. It is vital to conduct in-depth research to shed light on the possible links between inflammatory alveolar bone defects and miRNAs in order to develop creative strategies to prevent and cure inflammatory alveolar bone defects.
UMKM dan Efektivitas Promosi Online
Authors: alfalah salwa
Published: June 2021

Saat ini perkembangan teknologi di Indonesia sangat pesat, maka hal ini juga diikuti oleh perkembangan jumlah pengguna internet di Indonesia.
Gene therapy using extracellular vesicles loaded with miRNA derived from Bone Marrow Mesenchymal Stem Cells is a cell-free medication delivery method used in a variety of diseases
Authors: Dowaidar Moataz
Published: June 2021

The majority of neuro cancer research focuses on glioblastoma. BMSC-loaded miR-146b, miR-124a, miR-584, miR-133b, and miR-199a cause glioblastoma cell death by inducing apoptosis. These cancers have also been studied, but the number of studies is less than that of glioblastoma.Research into mental illness, renal injury, fibrosis, SCI, and stroke takes precedence over cancer research.MI is a well-researched disease model. miR-21, miR-132, miR-21a-5p, miR-125b, miR-214, miR-301, and miR-133 demonstrate cardioprotective properties according to these studies. miR-199a-5p, miR-486, miR-10, and miR-199a-3p suppressed the ER stress proteins and apoptotic proteins, reducing renal cell death from I/R. The use of miRNA-loaded BMSC EVs in the aforementioned fibrosis models was also proven. The research suggests that BMSC-derived EVs loaded with the aforementioned microRNAs have beneficial effects on ischemic and hemorrhagic stroke models. In SCI models, miR-133b, miR-29b, miR-21, miR-25, and miR-544 have been found to assist neural regeneration. Comparing these studies is difficult due to their complexity. These variables can be broken down as follows: Some studies only in vitro or in vivo studies, different cell lines or in vivo disease models were used in the studies, there were insufficient studies in some disease models, and different miRNAs determined by bioinformatics methods were used in each study. miRNA-derived BMSC-derived EVs are cell-free medication delivery approaches in a range of illness types. The technique employs bioinformatics analysis to find miRNAs that are downregulated in a disease model and/or miRNAs that target increased proteins in a particular signaling pathway. Electrical vehicles offer several benefits over cell-based transplantation and non-biological medication delivery technologies. To study the efficacy of this approach, there are no clinical trial investigations. A scarcity of immunogenicity and toxicity studies in these studies could hold back this method from going into clinical trials. It may be because EVs aren't intended for certain tissues or organs. Various strategies for EV membrane protein alterations and the creation of decorated EVs for cell-specific targeting have been devised. This is just a subset of the approaches available for targeted drug delivery. RVG/Lamp2b decorated EVs for nerve cell targeting can be mentioned. Additionally, superparamagnetic iron oxide nanoparticle modification of EV surfaces, chemical ligand assembly on exosomal surfaces, and pH gradient/surface charge-driven targeting may increase the efficacy of miRNA-loaded EV applications.
For the treatment of cystic fibrosis, RNA medicines, gene transfer therapies, and gene editing treatments have potential
Authors: Dowaidar Moataz
Published: June 2021

Many unique genetic procedures have been created to reach the heart of the cystic fibrosis (CF) problem, overcoming a defective gene, and advances in the nucleic acid treatment industry have made these methods much more viable as potential remedies. However, before any of these approaches can be used in clinical settings, a number of hurdles must be overcome, including determining which organs should be targeted for the most robust effect with the least amount of potential harm; determining which cells should be targeted in each organ; and determining what constitutes a successful treatment. Another factor to consider is that, unlike many other treatments, gene therapy and gene editing will need advancing clinical trials ahead without data from healthy adult control cohorts; rather, phase 1 studies will require CF patients. Furthermore, we must select which patients should be included in the initial studies for mutation-agnostic methods: should we include all patients, even if effective modulator therapy is available? Clearly, if we are to be successful, we will have to face some significant challenges, and we will have to do it as a cohesive group, as we have always done.
PERANGKAT PEMBELAJARAN MATEMATIKA MENGGUNAKAN PENDEKATAN PMRI DENGAN KONTEKS BUDAYA MASOHI PADA MATERI PERBANDINGAN SENILAI (Penelitian Pengembangan Pada Siswa Kelas VII SMP Negeri 1 Masohi)
Authors: Sohilait Emy
Published: June 2021

PERANGKAT PEMBELAJARAN MATEMATIKA MENGGUNAKAN PENDEKATAN PMRI DENGAN KONTEKS BUDAYA MASOHI PADA MATERI PERBANDINGAN SENILAI (Penelitian Pengembangan Pada Siswa Kelas VII SMP Negeri 1 Masohi)
Basal ganglia-cerebellar and brainstem-cerebellar circuits may interact improperly with dystonia. Linking network disruptions to cell failure will enable understanding pathophysiology and designing gene therapy methods
Authors: Dowaidar Moataz
Published: June 2021

From the preceding, it may be deduced that coupled dystonia syndromes are different, as are the disease phenotypes caused by the same gene. There are different starting ages, different symptom presentations, different disease manifestations, and atypical presentations. Accepting clinical exome sequencing and gene panels in the diagnosis of genetic diseases has also widened genotypes and phenotypes. It's critical to stay on top of the latest advances in genetic technology and to comprehend the full scope of these fascinating diseases. Online resources are updated on a regular basis and incorporate genetic and phenotypic data. Neurophysiology and imaging methods are important for better phenotyping and complementing clinical outcomes. Recent research suggests that the MYC/DYT-SGCE, XDP, and RDP basal ganglia-cerebellar and brainstem-cerebellar circuits may interact abnormally. Linking network interruptions to cellular failure will help us better grasp the underlying pathophysiology and teach us new treatment strategies.
The cubic polyhedral oligomeric silsesquioxanes based hybrid materials have a wide variety of applications, including drug administration, gene therapy, biological imaging, and bone regeneration
Authors: Dowaidar Moataz
Published: June 2021

The cubic polyhedral oligomeric silsesquioxanes (POSS), which has a well-defined compact frame, high symmetry, and various modified organic substitutes, has received much interest as one of the most critical building blocks for hybrid nanomaterials and self-assembly driven amphiphilics. This work assessed current molecular design advances, solution self-assembly capabilities, and anticipated biological applications of POSS-based hybrid materials. By adopting controlled/living polymerization techniques and considerable advancements in efficient chemical coupling techniques, preparation techniques for topological POSS-based hybrid materials have become a rapidly increasing research field with future advances. The resultant POSS hybrids with various functional groups help to create complicated, unique self-assembled morphologies in solutions, induced by discrete intermolecular interactions. POSS-based hybrid materials have a wide variety of applications, including drug administration, gene therapy, biological imaging, and bone regeneration, due to their particular benefits (such as high biocompatibility, low cytototoxicity, and good degradability) and simplicity of self-assembly behaviour.
RNAi treatment has been shown to successfully modify human-related target gene expression, including cancer. It has the capacity to control non-standard oncogenes, such as oncogenic lncRNAs
Authors: Dowaidar Moataz
Published: June 2021

Recent breakthroughs in clinical research and deployment of RNAi therapeutics have validated siRNA's promise to cure human diseases. RNAi therapy has been proven to effectively alter the expression of human-related target genes, including cancer. It has the potential to regulate oncogenes not addressed by standard treatment, such as oncogenic lncRNAs, to treat cancer more successfully. Due to their intrinsic liver affinity, successful RNAi therapies in clinical development primarily target liver diseases. Systemic dispersion of therapeutic siRNAs is an effective cancer therapy technique, especially for advanced diseases. Despite recent advances in siRNA delivery technologies, a problem remains with efficiently distributing siRNAs into solid tumors and cancer cells. To overcome several challenges to the dispersion of siRNA in cancer cells' cytoplasm, novel and highly effective delivery systems need to be devised. Delivery devices' ability to sense and adjust to environmental changes throughout the delivery process can make cytosolic distribution into cancer cells more efficient and accurate. Due to their well-defined and simple chemical structures and their multifunctionalities to respond to environmental changes to facilitate efficient cytosolic transport, environment-responsive lipids are promising platforms for clinical development to deliver siRNA. The primary benefit of simple, well-defined lipid structures over complex systems for cost-effective CMC and clinical translation is the simple, well-defined lipid structures. Environment-responsive lipids might be considered as simple, clever siRNA delivery methods that can overcome delivery difficulties for successful cancer treatment.
Small nuclear ribonucleoproteins (snRNPs) based gene therapy
Authors: Dowaidar Moataz
Published: June 2021

In 1968, Weinberg and Penman initially coined the term snRNA. Splicing is the process of eliminating introns from pre-RNA and combining exons The two forms of splicing are constitutive and alternative. U7 snRNP is a critical element in the unique 3′ end processing of replication-dependent histone (RDH) premRNAs. U7 Sm OPT uses antisense oligonucleotides to control pre-mRNA splicing. U7 snRNP has shown potential in preclinical studies and human clinical trials. DMD, ALS, thalassemia, HIV-1 infection, and spinal muscular atrophy are excellent illustrations of the majority of the problems (SMA) SmD1 and SmD2, which are found in other U snRNPs, are replaced by Lsm10 and Lsm11, respectively. There are just 500 molecules of U7SnRNP in a cell. Interesting because of its size, great stability, and tendency to collect in the nucleus of U 7 snRNA. The snRNP particle may hybridize to practically any RNA sequence in the nucleoplasm by altering the motif.U7 snRNA gene therapy is often employed to repair splicing abnormalities. The utilization of U7 Sm OPT-implanted antisense oligonucleotides has a multitude of potential therapeutic applications. More effective are the locations that bind U1 and U2 snRNPs to suppress splicing. useful for addressing splicing mistakes in muscular dystrophy, DMD, ALS, thalassemia, HIV-1 infection, and SMA PTCH1, BRCA1, and CYP11A have all been fixed with it. X-linked recessive muscular wasting illness, DMD. Individuals with exon 2 deletions either have asymptomatic or mildly symptomatic dystrophin levels. ANTISENSE oligonucleotides were introduced into the U7 Sm OPT and given via AAV to treat patients. These cells missed exon 2, resulting in an alternative translation starting at exon 6. (through an internal ribosome entrance region) The NIH's next clinical study will commence in January of 2020. U7 Sm OPT bifunctional gene therapy was successful in treating muscular dystrophy.Superoxide dismutase 1 (SOD1) gene mutations cause amyotrophic lateral sclerosis (ALS). SOD1 function was restored in a single study using U7Sm OPT to help rats with ALS. When given at birth, this medicine postponed sickness onset and enhanced life expectancy by 92% and 58%, respectively. Mutations in intron 2 produce a premature stop codon and hinder translation of full-length globin. Antisense oligonucleotides that span this region target nucleotides 102 to 130 of globin mRNA exon 1.5′ or 3′ splice site oligonucleotides in mammalian cells have been found to fix globin mRNA. The 654T > G mutation causes severe thalassemia symptoms. Combining U7 Sm OPT with induced pluripotent stem cells (iPSCs) led to a successful decrease of the globin gene
KEBUTUHAN ENERGI DALAM TUBUH
Authors: Husain Zulfa
Published: June 2021

Kebutuhan energi seseorang adalah konsumsi energi dari makanan yang diperlukan untuk menutupi pengeluaran energi seseorang bila ia mempunyai ukuran dan komposisi tubuh dengan aktivitas yang sesuai dengan kesehatan jangka panjang dan yang memungkinkan pemeliharaan aktivitas fisik yang dibutuhkan secara sosial dan ekonomi.Sumber energi adalah bahan makanan sumber lemak, seperti lemak dan minyak, kacang-kacangan dan biji-bijian. Selain itu bahan makanan sumber karbohidrat, seperti padi-padian, umbi-umbian dan gula murni.Hasil kajian menunjukkan kisaran distribusi energi gizi makro dari pola konsumsi penduduk Indonesia berdasarkan analisis data Riskesdas 2010 adalah 9-14% energi protein, 24-36% energi lemak, dan 54-63% energi karbohidrat Yang belum sebaik yang diharapkan, Yaitu 5-15% energi protein, 25-55% energi lemak, dan 40-60% energi karbohidrat tergantung usia atau tahap tumbuh kembang.
UMKM Indonesia yang Berhasil Bertahan di Masa Pandemi COVID-19
Authors: Leo Grasella Helena
Published: June 2021

Di masa pandemi, perekonomian Indonesia lebih baik dan lebih berkembang, mengingat sektorlain mengalami penurunan, seperti pangan. Untuk itu, ada banyak kategori di sektor ekonomi yang perludiperhatikan, yakni bisnis dari kelas bawah hingga kelas menengah.Untuk bisnis kelas menengah bisa berupa UMKM dan retail. Namun yang paling disorot olehinvestor atau pelaku bisnis adalah UMKM yang semakin berkembang dengan teknologi saat ini.
The use of a network medicine approach might result in innovative strategies for lowering coronary heart disease and CV risks
Authors: Dowaidar Moataz
Published: June 2021

The reductionist approach of stringent guidelines for treating dyslipidemia led to significant lipoprotein transported cholesterol (LDLC) reduction with statin-based treatment to prevent or postpone development of atherosclerosis. Correct estimation of residual CV risk, however, remains a critical problem requiring the development of new integrated approaches Using a network-medicine approach might lead to creative methods. This is clearly a multidisciplinary technique that will be difficult in a clinical situation. To get a comprehensive picture of nodes and disease modules, we need to dissect a dyslipidemic patient to the level of single-cell analysis and then reconstruct the picture. These efforts are crucial to understanding the molecular networks that drive dyslipidemia and atherosclerosis. Moreover, in clinical assessment of persons with suspected coronary heart disease (CHD), computer-aided decision-making is more widespread. On the other hand, doctors should remember that robots lack a "sense of thinking" and should thus distrust the reliability of a purely robotic clinical decision. As a consequence, AI should be called "increased intelligence," which can help physicians make judgments but should keep the ultimate strategy in the physician's hands.
Penggunaan energi dalam tubuh
Authors: T Mutiara
Published: June 2021

Membahas tentang penggunaan energi dalam tubuh
Preclinical investigations revealed possibilities for Salmonella tumor treatment. Bacteria can also be coupled to nanomaterials enabling drug-loading, photocatalytic and/or magnetic properties, using the bacteria's net negative charge
Authors: Dowaidar Moataz
Published: June 2021

Except in human clinical trials, preclinical tests showed the potential of Salmonella bacteria for tumor therapy. There are still various challenges to tackle before salmonella bacteria may be employed to treat human cancer. Due to its pathogenic nature, attenuation is essential to minimize the host's harmful effects of bacterial infection. Loss of anticancer efficacy from bacterial virulence attenuation can be compensated by giving therapeutic payloads to microorganisms. Bacteria can also be linked to micro-or nanomaterials with diverse properties, such as drug-loaded, photocatalytic and/or magnetic-sensing nanoparticles, using the net negative charge of the bacteria. Combining bacteria-mediated cancer treatment with other medicines that have been clinically shown to be helpful but have limits may provide surprising therapeutic results. Recently, this strategy has received attention and is underway. The use of live germs for cancer treatment has not yet been approved for human clinical trials. The non-invasive oral form of administration benefits from safety, making it more suitable for clinical cancer patients.Infection of live germs through systemic means, on the other hand, involves toxicity risk. Although Salmonella bacteria can be genetically manipulated with high tumor targeting, harm to normal tissues can not be excluded when medications with nonspecific toxicity are administered. It is preferred if the action of selected drugs may be restricted to the tumor site rather than healthy tissues, thereby boosting cancer therapy safety. In recent years, many regulatory mechanisms have been developed to manage pharmaceutical distribution through live bacterial vectors. Engineered salmonella can accumulate 1000 times greater than normal tissue density in the tumor. The QS-regulated mechanism, which initiates gene expression when bacterial density exceeds a particular threshold level, also promises Salmonella bacteria for targeted medication delivery. Nanovesicle structures of Salmonella bacteria can also be used as biocompatible nanocarriers to deliver functional medicinal chemicals in cancer therapy. Surface-modified nanovesicles preferably attach to tumor cells and are swallowed by receptor-mediated endocytosis before being destroyed to release packed drugs. The xenograft methodology, which comprises the implantation of cultivated tumor cell lines into immunodeficient mice, has often been used in preclinical research revealing favorable results about the anticancer effects of genetically engineered salmonella.
penggunaan energi dalam tubuh
Authors: Husain Zulfa
Published: June 2021

Energi dibutuhkan oleh tubuh agar sel dan jaringan tubuh tetap sehat, tumbuh dan berkembang, serta fungsinya berjalan dengan baik.Energi dihasilkan melalui proses metabolisme tubuh dengan cara mengubah makanan dan minuman yang dikonsumsi. Metabolisme tubuh merupakan proses kimia yang terjadi di dalam sel tubuh untuk mengubah makanan dan minuman yang Anda konsumsi menjadi energi Beberapa fungsi tubuh yang dipengaruhi oleh proses metabolisme adalah bernapas, mencerna makanan, mengalirkan darah, memperbaiki dan memperbarui sel, mengendalikan suhu tubuh, memicu kontraksi otot, menghilangkan limbah melalui urine dan feses, serta menjaga fungsi otak dan saraf. Metabolisme tubuh bekerja melalui dua proses, yaitu katabolisme dan anabolisme, yang berlangsung secara bersamaan.
LncRNA regulating reprogramming glucose metabolism has become one of the most tempting antineoplastic targets for gene therapy
Authors: Dowaidar Moataz
Published: June 2021

The hallmark of carcinogenesis is reprogramming glucose metabolism, and accumulating evidence shows that this process may be affected by a range of circumstances. This review emphasizes LncRNA's relevance in modulating glucose metabolism. As stated before, LncRNA works as a key regulator in a complex network encompassing metabolic enzymes, oncogenes, tumor-inhibiting medicines and metabolic signaling pathways. The crucial variable in personalizing therapy to best fit patient needs and preferences is the availability of multiple treatment alternatives with varied procedures. By introducing targeted therapeutic approaches including small molecule inhibitors, RNAi, and ASO gapmer, LncRNA has become one of the most tempting antineoplastic targets. However, the road to LncRNA-based therapy remains long and challenging due to LncRNA's complexity and lack of information. A new study on LncRNA's function in metabolism is needed to uncover new markers and treatment goals to regulate this abnormal metabolic development. Translational medicine also has to improve the delivery technique to maximize impact with less toxicity and off-target consequences.
Transcriptomics is a rapidly growing field that generates new data that may be used on its own or in combination with existing clinical data for development of new therapeutics, including gene therapy
Authors: Dowaidar Moataz
Published: June 2021

Transcriptomics is a rapidly growing field that generates new data that may be used on its own or in combination with existing clinical data to widen and affect the future of healthcare. While the majority of current applications are limited to research, a growing number of studies suggest that transcriptomics has applications in diagnostics, genomics-driven trial design, and the creation of personalized medicines. Blood samples can be collected in general practice and submitted to a central lab for analysis and interpretation before being provided to the doctor, allowing for greater clinical acceptance of experimental hypotheses. The transcriptome's immense complexity has been revealed by transcriptomics, and we're just beginning to understand how this translates to function, disease, and therapeutic options.
Democracy Scale For Teacher Candidates: A Validity And Reliability Study
Authors: Kaya Fatih
Published: June 2021

The aim of this study was to develop a valid and reliable measurement tool in order to determine the democracy levels of teacher candidates. During the scale development process in the research, the validity and reliability studies were conducted through three independent study groups. The first study group consisted of 627 students studying at the Faculty of Education in Inonu University in the 2020-2021 academic year, the second study group consisted of 324 students, and the third study group consisted of 87 students. “The Democracy Scale for Teacher Candidates” was used in the research. In the process of data analysis, SPSS 25 software was used for exploratory factor analysis and AMOS 21 software for confirmatory factor analysis. An item pool consisting of 50 items was created for the scale. The number of items was reduced to 40 by obtaining expert opinion in order to ensure the content validity of the scale. As a result of the factor analysis, it was determined that the total variance ratio explained by the single-factor scale with 17 items was 49.640%, and the internal consistency coefficient was .88. In addition to these, the values obtained as a result of the confirmatory factor analysis conducted to test the construct validity of the scale showed that the scale developed to determine the democracy levels of teacher candidates was valid and reliable.
Magnetic nanoparticles are widely used in drug delivery, imaging, diagnosis, and targeting. It has promises for the treatment of inflammatory disorders such as rheumatoid arthritis
Authors: Dowaidar Moataz
Published: June 2021

Rheumatoid arthritis (RA) is an autoimmune disease that causes persistent inflammation and joint damage. Traditional medications like methotrexate, leflunomide, and antimalarials, as well as novel biological medicines like adalimumab, etanercept, and infliximab, make up the DMARDs. New medications, such as upadacitinib17, a specific JAK-1 inhibitor, and rituximab have recently been introduced to the RA treatment arsenal. Nanoparticles are able to travel across loose vasculature and penetrate into inflammatory areas and tumor sites due to their unique physical features. The application of MNPs in the treatment, diagnosis, and targeting of rheumatoid arthritis is the topic of this review.Nanotechnology is a subset of nanomaterials that are widely used in drug delivery, imaging, diagnosis, and targeting.It has been used to treat malignancies and, more recently, the treatment of inflammatory disorders such as rheumatoid arthritis. The findings have motivated scientists to test MNPs in a variety of disorders. While research into magnetically focused treatment and diagnostics is still in its early phases, it has already shown great potential. MNP technologies confront a number of challenges, including not just overcoming their inherent weaknesses, but also keeping up with the times. Using a single-cell method, the diversity of synovial cells and immune cells in joints was discovered. Precision therapy necessitates the application of MNP technology to further target specific cells. Because of the efficacy of exosomes in treating RA, bio-membrane encapsulated MNPs have been developed. Furthermore, the discovery of MNPs' effects on cell autophagy and metabolism has ushered in a new era in the mechanistic research of magnetic nanoparticles. Overall, magnetic nanoparticle modification is a promising platform for treating rheumatoid arthritis that is both promising and challenging.
The nanomedicine system has successfully inhibited tumor neovascularization using gene silencing, chemotherapy, photothermal therapy, and other therapies
Authors: Dowaidar Moataz
Published: June 2021

Customized nanomedicines can be used in a variety of ways, including angiogenesis suppression, vascular disruption, and vascular infarction. In the angiogenesis suppression approach, VEGF, VEGFR, mTOR, EGFR, bFGF, ROS, and other components have become promising therapeutic targets. The nanomedicine system has successfully inhibited tumor neovascularization using gene silencing, chemotherapy, photothermal therapy, and other therapies. In the vascular disruption approach, VDAs supplied by nanomaterials were bonded with the bonding sites of CA4, COL, PTX, and other medications on microtubules to promote rapid disintegration of tumor vascular wall cells. Combining many medicines increased the tumor treatment outcome even more. For example, disruption of tumor blood arteries caused by nanoparticle-mediated physical methods combined with chemotherapy resulted in effective treatment in a large volume tumor model. The vascular infarction methodology uses a variety of carriers, including nanoparticles, DNA nanorobots, platelet membranes, and others, to carry thrombin, tTF, and other drugs to generate local thrombosis and provide safe and effective tumor treatment.
CAR T-cell treatment remains clinically challenging. Therapeutic strategies may be designed to cut off immunotherapy utilizing safety switches
Authors: Dowaidar Moataz
Published: June 2021

CAR T-cell therapy still has clinical research problems. Suicide genes, combinatorial target-antigen recognition, synthetic Notch receptors, on-switch CARs, inhibitory CARs and armored CARs may all be engineered to turn off immunotherapy using safety switches. Combining CAR T-cell therapy with immunomodulatory medications such as ibrutinib, lenalidomide, or checkpoint inhibitors may extend the duration of therapeutic response. The effect of checkpoint inhibitors on infection risk is complicated and depends on pathogen, cell and organ-specific variables. The natural history of asymptomatic or moderately symptomatic COVID-19 infection is unknown, and further study is needed to evaluate if CAR T. Therapy should be postponed in individuals in severe need of possibly curative therapy. Several strategies should be used to address these research issues. These include registry studies, well-designed studies to identify infection risk factors and homogeneous populations.
KEBUTUHAN ENERGI GIZI DALAM TUBUH
Authors: Inayaht Nurul , Yuniar Sugira Selfi
Published: June 2021

Energi Tubuh memerlukan energi sebagai sumber tenaga untuk segala aktivitas. Energi diperoleh dari makanan sehari-hari yang terdiri dari berbagai zat gizi terutama karbohidrat dan lemak. Energi yang dipergunakan untuk melakukan pekerjaan, dilepaskan dalam tubuh pada proses pembakaran zat-zat makanan. Dengan mengukur jumlah energi yang dikeluarkan itu dapat diketahui berapa banyak makanan yang diperlukan untuk menghasilkannya (Soediaoetama,2000). Kebutuhan energi seseorang adalah konsumsi energi dari makanan yang diperlukan untuk menutupi pengeluaran energi seseorang bila ia mempunyai ukuran dan komposisi tubuh dengan aktivitas yang sesuai dengan kesehatan jangka panjang dan yang memungkinkan pemeliharaan aktivitas fisik yang dibutuhkan secara sosial dan ekonomi (Beck,1993 dan Almatsier, 2001). Sumber energi adalah bahan makanan sumber lemak, seperti lemak dan minyak, kacang-kacangan dan biji-bijian. Selain itu bahan makanan sumber karbohidrat, seperti padi-padian, umbi-umbian dan gula murni.Hasil kajian menunjukkan kisaran distribusi energi gizi makro dari pola konsumsi penduduk Indonesia berdasarkan analisis data Riskesdas 2010 adalah 9-14% energi protein, 24-36% energi lemak, dan 54-63% energi karbohidrat Yang belum sebaik yang diharapkan, Yaitu 5-15% energi protein, 25-55% energi lemak, dan 40-60% energi karbohidrat tergantung usia atau tahap tumbuh kembang. (IOM, 2005)
Sumber gizi dan penilaian status gizi
Authors: Hadza Roza Qoni
Published: June 2021

Sumber zat gizi berasal dari zat gizi makro dan mikro.zat gizi makro terdiri dari karbohidrat,protein dan lemak. Sedangkan zat gizi mikro terdiri dari vitamin dan mineral. Dalam penilaian status gizi ,terdapat 2 cara yaitu langsung dan secara tidak langsung
Anderson–Fabry disease can be a target for gene therapy
Authors: Dowaidar Moataz
Published: June 2021

The perspective of Anderson–Fabry disease (ADF) therapy is changing, and we should be ready to adapt to any new information. Today, ERT is still a viable therapeutic option for AFD patients. Chaperone therapy may be beneficial as a first-line treatment for adult patients with amenable mutations. In the near future, the PEGylate enzyme may be approved and added to our indications. SRT, gene therapy, and other enzyme preparations, such as moss alpha gal, are all still in the development phases.
Genetic variants shared between Alzheimer's disease and Parkinson's disease have been discovered in blood and brain samples. Somatic mosaicism might function as an accelerator
Authors: Dowaidar Moataz
Published: June 2021

Alzheimer's disease and Parkinson's disease are the most prevalent aging-related neurodegenerative disorders. Controversy continues over amyotrophic lateral sclerosis being classified as an aging-dependent neurodegenerative disease. Systems biology techniques are required to parse and integrate models to provide insights into the link between genetic features and phenotypes. The H2 MAPT haplotype, which codes for the microtubule-associated protein tau, has been related to LOAD risk. New research is now examining postzygotic variation in post-mortem variation in brain tissues of AD patients. The genome has been found to have 50% of the autosomal recessive parkinsonism patients with EO Parkinsonism and sensorimotor polyneuropathy. The gene for this gene, Park7, also known as DJ1, is the third gene involved with EOPD. It is the most frequent genetic risk factor for PD. This whole-genome sequencing had a 50-coding-exon deletion (from exon 17 to exon 66) in a patient with Eo Parkinsonism.
Emerging therapy options may help patients with RAG deficiency, especially those with severe immune dysregulation
Authors: Dowaidar Moataz
Published: June 2021

New understandings about RAG1 and RAG2 gene expression have recently been gained. Rag expression molecular pathways are now known to support research on genetic variants that influence regulatory domains for lymphoid development. The RAG1/RAG2 complex might serve as a model for RAG alterations in vivo and in vitro recombination experiments. These data indicate the approximate relationship between RAG deficiency genotype and phenotype. Although this concept has not yet been proven, it is theorized that hypomorphic RAG mutations restrict RAG complexes and interfere with appropriate T-and B-cell development.A unique cellular and animal model has uncovered significant immunological and clinical insights regarding RAG mutations. Rag mutations causing below-normal levels of T and B cell development have considerable ramifications on thymic lymphostromal cross talk as well as on receptor editing in the bone marrow and on the survival of self-reactive peripheral B cells. These difficulties account for the higher occurrence of autoimmune symptoms in people and animals with hypomorphic RAG mutations. A study looking at human T cell development used the in vitro methodology to investigate RAG-mutant mice. Finally, emerging therapy options may help patients with RAG deficiency, especially those with severe immune dysregulation. Useful therapy could benefit other people with immune inborn errors as well.New exploratory approaches are emerging to help cure RAG deficiency. These techniques have offered a distinct understanding of RAG deficiencies employing artificial thymic organoids (ATOs) and induced pluripotent stem cells, respectively (iPSCs). novel possible therapeutic approaches, such as lentiviral vector‐mediated gene therapy, gene editing, and nongenotoxic conditioning regimens for hematopoietic stem cell transplantation (HSCT).
Suicide gene therapy may be effective in the treatment of malignant glioma
Authors: Dowaidar Moataz
Published: June 2021

Suicide gene therapy has a long history, and its effectiveness is now under investigation. The bystander death effect therapeutic strategy proved successful in treating malignant glioma; nevertheless, non-replicating viral vectors may not be able to cover a large invading region of glioma cells. Tumor-trophic stem cell migration and viral replication capacities have the potential to overcome the refractory mechanisms of malignant glioma. Surprisingly, the time to response (partial or total response) was delayed for more than 6 months after the initial Toca 511 treatment, reflecting a stronger antitumor immune response. Immunosuppressive cells such myeloid-derived suppressor cells and tumor-associated macrophages were found to be lower in human glioblastoma tissues after treatment. These mechanisms may have a long-term impact on people with malignant glioma. NSCs and MSCs, for example, might be employed to cover glioma cells' more broad invading areas. However, we must investigate which brain stem cells are the most suited. More study is needed to confirm the migratory potential and survival ratio of the implanted stem cells in the brain utilizing comparative analysis. Suicide gene therapy using stem cell migratory capability and/or viral replicating capability for malignant glioma may recapture the spotlight.
SUMBER ZAT GIZI
Authors: Inayaht Nurul , Bagenda Faradibah
Published: June 2021

Penilaian status gizi merupakan penjelasan yang berasal dari data yang diperolehdengan menggunakan berbagai macam cara untuk menemukan suatu populasi atau individuyang memiliki risiko status gizi kurang maupun gizi lebih (Hartriyanti dan Triyanti, 2007).
Ferropsis cell death can cause complications that may be difficult to detect and quantify: autophagy role and possible therapeutics
Authors: Dowaidar Moataz
Published: June 2021

It is possible to understand both the processes of ferroptosis and how this type of cell death will be harnessed in the near future. The novel ferroposis-based therapies will also be created and evaluated using various biomarkers. Selenium and vitamin E have been shown to support some types of cancer in several studies. Such environmental factors should be accounted for while exploring ferroaptosis's duties. The effect of these modifications will be dictated by the cellular and environmental context in which they are created. It is critical to determine whether the inhibitor can act as a lipophilic radical-trapping antioxidant and prevent ferroPTosis independently of the enzyme under investigation, as several studies with lipoxygenases have shown.Using pharmacological approaches to evaluate ferropsosis can have potential side effects that are difficult to measure. Using small-molecule probes may be investigated using small-molecules probes. It's essential to utilize a biochemical test or a pharmacodynamic marker of target inhibition when employing RSL3 to inhibit GPX4, or when using erastin to inhibit the system xc–cystine/glutamate antiporter, or by using an Xc–Cystine/Glutamate/Glutamic antiporter inhibitor, or an erast inhibitor, to inhibit Gpx4, GSH, and other types of protein thiols, such as GSH and protein thiola. Many tiny molecules that are potent and selective probes in cellular assays have limited applicability in animal studies. RSL3, a poor solubility, is useful only in instances when an injection is made directly into tissues or tumors. Interfering with iron to modulate ferroptosis has far-reaching ramifications. Findings obtained with iron chelators only should be interpreted with caution as depleting iron can have other side effects other than ferroPTosis suppression.
Social belongingness and wellbeing: a review of constructs and evidence as introduction to the special Frontiers in Psychology-Social Psychology issue
Authors: Páez Darío
Published: June 2021

This is an expanded version of Oyanedel, J.C. & Páez, D. (2020). Editorial: Social Belongingness and WellBeing: International Perspectives. Frontiers of Psychology. 11Includes all meta-analyses main results and a largest discussion of constructs.
RUSSIAN APPROACH TOWARDS SOVEREIGNTY AND ITS ROLE IN THE GREATER EURASIAN PARTNERSHIP
Authors: Skriba Andrei , Drozdova Anna
Published: June 2021

Over the last twenty years Russian approach towards sovereignty has underwent significant changes and has become more rigid and defined. After numerous attempts to integrate into the West, Russia began to acquire its own identity, but no longer as an appendage of Europe, which was not supposed to be reckoned with as an equal, but as a central Eurasian power, acting not only as a balancing county between East and West, but also as the security provider in the Eurasian region. In this regard, the article examines how the Russian approach towards sovereignty fits into the concept of the Greater Eurasian community. From this point of view, the Greater Eurasian Partnership, which is a continuation of Moscow’s policy of revising the world order that has developed after the end of the Cold War, has not only geopolitical and geo-economic aspects, but also cultural and normative ones: the emergence of a community of countries where relations are built on mutual respect for the sovereignty of each other. It is sovereignty, according to the authors, that underlies both the concept of Greater Eurasia and other Russian foreign policy initiatives in this direction.
CHINA’S «ONE BELT, ONE ROAD» GLOBAL INFRASTRUCTURE PROJECT AND ENVIRONMENTAL ISSUES
Authors:   INION RAN, Pekhtereva Elena
Published: June 2021

China’s Belt-and-road Initiative is the largest infrastructure project of our time. However, there are reasonable concerns about its impact on the environment, the consequences of which are not always obvious. Understanding the depth of environmental problems that arise during the implementation of the project, and how to solve them, is necessary for both China and the other countries involved to ensure a sustainable positive socio-economic effect.
ETHNIC AND CONFESSIONAL IN ISLAM: IS “TRUE ISLAM” SO RELIGIOUSLY PURE?
Authors: Dobaev Igor
Published: June 2021

Since the 1980s of the 20 century ideology, and then the practice of the so-called “Pure Islam” began, under external influence, to sneak actively to the territory of Russia. Its adherents entered into irreconcilable confrontation with the supporters of traditional Islam and it resulted in the emergence and development of religious and political extremism and terrorism under the guise of Moslem beliefs. In this regard, it seems relevant to find out whether the so-called “pure Islam,” free from the influence of ethnicity and traditional values really exists.
THE ROLE OF ULAMA1 IN THE PUBLIC LIFE IN SYRIA (1970-2020)
Authors: Bibikova Olga
Published: June 2021

Religion still plays a significant role in Syria, despite the fact that the civil war divided Syrians into supporters of the government and its opponents. Inside a large group of Muslim sheikhs, there is also no agreement.
MORALITY AND RELIGION: SETTING THE EVOLUTIONARY AND PHILOSOPHICAL SCENE
Authors:   INION RAN, Tsibizova Irina
Published: June 2021

The article cities the Finnish thinkers’ visions of morality and religion relations from the philosophic, theological and sociologist points of view, the gods’ morality problem and the religion’s influence on human cooperation.
DISCUSSION BETWEEN MIKHAIL SERYAKOV AND DMITRY CHURAKOV ON THE ROLE OF THE FEMININE IN PRIMITIVE SOCIETY
Authors:   INION RAN, Glukhov Sergei
Published: June 2021

The review examines the discussion of domestic researchers on the role of the feminine principle in primitive society.