bluuebunny/crossref_metadata_2025 huggingface dataset:
Flexible and fine-grained simulation of speed in language processing
Authors: Pan Xueyao , Liang Bingqian , Li Xi
Published: April 2024

According to the embodied cognition theory, language comprehension is achieved through mental simulation. This account is supported by a number of studies reporting action simulations during language comprehension. However, which details of sensory-motor experience are included in these simulations is still controversial. Here, three experiments were carried out to examine the simulation of speed in action language comprehension. Experiment 1 adopted a lexical decision task and a semantic similarity judgment task on isolated fast and slow action verbs. It has been shown that fast action verbs were processed significantly faster than slow action verbs when deep semantic processing is required. Experiment 2 and Experiment 3 investigated the contextual influence on the simulation of speed, showing that the processing of verbs, either depicting fast actions or neutral actions, would be slowed down when embedded in the slow action sentences. These experiments together demonstrate that the fine-gained information, speed, is an important part of action representation and can be simulated but may not in an automatic way. Moreover, the speed simulation is flexible and can be modulated by the context.
Understanding physical exercise among individuals with substance use disorders using an integrated theoretical perspective of the health action process approach and theory of planned behavior
Authors: Meng Yong , Zhu Ting , Chen Wei , Zhou Hongjie , Tao Lanping , Wang Xiaoteng , Li Mengya , Zhang Xiaofang , Wang Dongshi , Wu Xingyue , Luo Shaochen , Hu Cheng
Published: April 2024

Introduction

Physical exercise is considered a useful non-pharmacological adjunctive treatment for promoting recovery from substance use disorders (SUD). However, adherence to physical exercise treatments is low, and little is known about what factors are associated with the initiation and maintenance of physical exercise behaviors. The aim of this study was to explore the psychosocial factors underlying these behaviors in individuals with SUD using an integrated theoretical model based on the health action process approach (HAPA) and the theory of planned behavior (TPB).

Methods

A total of 1,197 individuals with SUDs (aged 37.20 ± 8.62 years) were recruited from 10 compulsory isolation drug rehabilitation centers in Zhejiang Province via convenience sampling according to a set of inclusion criteria. Self-reported data were collected to assess task self-efficacy (TSE), maintenance self-efficacy (MSE), recovery self-efficacy (RSE), outcome expectations (OE), action planning (AP), coping planning (CP), social support (SS), subjective norms (SN), attitude behavior (AB), behavioral intention (BI), perceived behavioral control (PBC), risk perception (RP), exercise stage, and exercise behavior in this integrated model. ANOVA and structural equation modeling (SEM) were used to evaluate this model.

Results

One-way ANOVA revealed that the majority of the moderating variables were significantly different in the exercise phase. Further SEM showed that the model fit the data and revealed several important relationships. TSE, RP, SS, AB, and SN were indirectly associated with physical exercise behavior in individuals with SUD through the BI in the SUD initiation stage. In addition, PBC was directly related to physical exercise behavior in individuals with SUD. In the maintenance stage, MSE, AP, CP and exercise behavior were significantly related. Moreover, AP and CP were mediators of BI and MSE.

Conclusion

This study is the first attempt to integrate patterns of physical exercise behavior in individuals with SUD. The HAPA-TPB integration model provides a useful framework for identifying determinants of physical exercise behavioral intentions and behaviors in individuals with SUD and for explaining and predicting the initiation and maintenance of physical exercise behaviors in these individuals. Moreover, the model provides scientific guidance for the enhancement of physical exercise adherence in individuals with SUD.
Psychological correlates of physical activity among adults living in rural and urban settings
Authors: Sirotiak Zoe , Brellenthin Angelique G. , Hariharan Arjun , Welch Amy S. , Meyer Jacob D. , Franke Warren D.
Published: April 2024

Middle-aged and older adults living in rural settings have been consistently less likely to report regular physical activity (PA) than those living in urban settings. While past literature has identified sociodemographic and environmental correlates of PA that may contribute to these differences, consideration of psychological correlates has been limited. A total of 95 rural and urban adults ≥50 years old provided self-reported sociodemographic information, PA level, and psychological correlates of PA including measures assessing motivation, self-efficacy, social support, and attitudes related to PA. The average participant age was 68.6 years, and most were female (62.1%) and married (70.5%). While PA level did not differ significantly between the rural and urban groups, different psychological correlates contributed significantly to separate rural and urban linear regression models considering PA status. Among rural adults, more positive attitudes toward PA, and greater PA self-efficacy and social support were associated with greater amounts of PA while for urban adults, no psychological correlates were significantly associated with PA. Psychosocial factors may be key considerations in developing more effective PA interventions in middle-aged and older adults living in rural areas.
Community health worker perspectives on advocacy: design-based research to develop a digital advocacy training course
Authors: Job Nophiwe , Johnston Jamie Sewan , Westgate Carey , Skinner Nadine Ann , Ward Victoria , Ballard Madeleine ,   CHW Advisory Group
Published: April 2024

Introduction

While community health workers (CHWs) are well-positioned as health advocates, they frequently lack support and feel undervalued. Advocacy training may prepare CHWs to support communities better.

Methods

This study uses a design-based research approach to (1) explore how participation in curriculum-development workshops for a digital advocacy course influenced CHWs’ (n = 25) perceptions of advocacy and (2) describe how CHW involvement shaped course development. Data were collected via five discussion groups and seven surveys over six months.

Results

Initially, the CHWs perceived themselves as community-advocates but not as self-advocates. They increasingly reflected on the merits of advocating for better working conditions and aspired to greater involvement in decision-making. CHWs reflected positively on their advisory role in shaping the course to improve content acceptability and validity.

Discussion

Training efforts to engage CHWs in advocacy must overcome systemic barriers and norms internalized by CHWs that deter them from reaching their full potential as advocates.
Environmental health, economy, and amenities interactively drive migration patterns among China's older people
Authors: Wang Hongjie , Gao Xiaolu , Liu Guili , Wang Fuyuan , Rosenberg Mark W.
Published: April 2024

The increasing number of older adult migrants is rapidly changing regional demographic and social structures in China. There is an urgent need to understand the spatial patterns and factors that influence older adults to migrate, especially the role of environmental health. However, this issue has been under-studied. This study focused on intra-provincial and inter-provincial older adult migrants as research subjects, estimated their spatial concentration index based on the iterative proportional fitting approach, and explored the factors influencing their migration using the GeoDetector Model. The results showed the following: (1) In 2015, more than 76% of inter-provincial older adult migrants were distributed in Eastern China, and most intra-provincial older adult migrants were scattered in sub-provincial cities. (2) Compared to factors relating to economy and amenities, environmental health by itself played a relatively weak role in the migration of older adults, but the interaction among environmental health, economy, and amenities was a key driving force of older adult migration. (3) There were significant differences in the dominant environmental health factors between inter-provincial migration and intra-provincial migration, which were temperature and altitude, respectively. Our findings can help policymakers focus on the composition of older adult migrants based on urban environmental health characteristics and rationally optimize older adult care facilities to promote supply-demand matching.
Prevalence and factors associated with suicidal ideation and attempts among mentally ill patients in the psychiatry OPD at St. Paul's Hospital Millennium Medical College, Addis Ababa, Ethiopia
Authors: Mohammed Awol Dawud , Menna Takele , Ayalew Mohammed , Teshome Tesfalem , Alayu Mikiyas , Tesfay Neamin
Published: April 2024

Background

Every year, more than 800,000 people die due to suicide (one person every 40 s), ranking as the second leading cause of death next to traffic accidents in individuals aged 15–29 years. The objective of this study was to assess the prevalence and factors associated with suicidal ideation and attempts among mentally ill patients.

Method

An institutional-based, cross-sectional study was conducted between December 2019 and January 2020. Data were collected using a convenient sampling technique until the required sample size was achieved. The total sample size was 385. The Suicidal Behavior Questionnaire-Revised (SBQ-R), Oslo Social Support Scale, and self-prepared to assess suicide were used. Data collection was carried out by psychiatry professionals through face-to face interviews. Data were analyzed, and bivariate and multivariable logistic regression analyses were conducted using Statistical Package for the Social Sciences (SPSS) version 23.

Result

A total of 385 patients participated in the study. Of these, 216 (56%) were men. The prevalence of suicide ideation was 255 (66.2%). The odds of suicidal ideation and attempt was almost three times higher [adjusted odds ratio (AOR) = 2.79, 95% confidence interval (CI) 1.11–6.98]; among patients who felt hopeless, the OR was around two times higher (AOR = 2.44, 95% CI 1.17–5.08); among patients who had a family history of suicide, the OR was almost three times higher (AOR = 2.56, 95% CI 1.00–6.53); among patients who stopped their medication, the OR was approximately two times higher (AOR = 2.25, 95% CI 1.14–4.46); the OR of suicidal ideation and attempts was almost six and four times higher (AOR = 5.86, 95% CI 1.30–26.41; and AOR = 3.61, 95% CI 1.01–12.88) among patients who were educated to primary and secondary level, respectively.

Conclusion

In this study, carried out in Ethiopia, suicidal ideation and attempts were more common among men than women. The prevalence of suicidal ideation and attempts showed a significant public health issue among hospital-attending and chronic mentally ill adolescents, which requires a large emphasis. We recommend that suicide prevention needs to involve non-governmental and non-profit organizations, universities, and civil society at different levels.
Shining a light on the road towards conducting principle-based co-production research in rehabilitation
Authors: Bourke John A. , Bragge Peter , River Jo , Sinnott Jerram K. Anne , Arora Mohit , Middleton James W.
Published: April 2024

Moving from participatory approaches incorporating co-design to co-production in health research involves a commitment to full engagement and partnership with people with lived experience through all stages of the research process—start to finish. However, despite the increased enthusiasm and proliferation of research that involves co-production, practice remains challenging, due in part to the lack of consensus on what constitutes co-production, a lack of guidance about the practical steps of applying this approach in respect to diverse research methods from multiple paradigms, and structural barriers within academia research landscape. To navigate the challenges in conducting co-produced research, it has been recommended that attention be paid to focusing and operationalising the underpinning principles and aspirations of co-production research, to aid translation into practice. In this article, we describe some fundamental principles essential to conducting co-production research (sharing power, relational resilience, and adopting a learning mindset) and provide tangible, practical strategies, and processes to engage these values. In doing so, we hope to support rehabilitation researchers who wish to engage in co-production to foster a more equitable, ethical, and impactful collaboration with people with lived experience and those involved in their circle of care.
A review of visual SLAM for robotics: evolution, properties, and future applications
Authors: Al-Tawil Basheer , Hempel Thorsten , Abdelrahman Ahmed , Al-Hamadi Ayoub
Published: April 2024

Visual simultaneous localization and mapping (V-SLAM) plays a crucial role in the field of robotic systems, especially for interactive and collaborative mobile robots. The growing reliance on robotics has increased complexity in task execution in real-world applications. Consequently, several types of V-SLAM methods have been revealed to facilitate and streamline the functions of robots. This work aims to showcase the latest V-SLAM methodologies, offering clear selection criteria for researchers and developers to choose the right approach for their robotic applications. It chronologically presents the evolution of SLAM methods, highlighting key principles and providing comparative analyses between them. The paper focuses on the integration of the robotic ecosystem with a robot operating system (ROS) as Middleware, explores essential V-SLAM benchmark datasets, and presents demonstrative figures for each method’s workflow.
The Secret World of “Jumping” DNA
Authors: Šatović-Vukšić Eva , Plohl Miroslav
Published: April 2024

Transposons are unusual segments of DNA that can affect genes and create new traits, helping to make every living thing special. Transposons have the amazing ability to move around within an organism’s DNA, and they can even travel between organisms! Transposons can be activated by stress, helping organisms to cope and adapt. Researchers are using transposons as special delivery systems to help cure diseases. Also, studying transposons can provide a lot of information on how the biodiversity of life on Earth has changed over millions of years. They can help each other in their journeys, practicing teamwork. The unique features of these “jumping” DNA segments even earned scientists a Nobel Prize for their discovery.
Robodeport or surveillance fantasy?: how automated is automatic visa cancellation in Australia?
Authors: Weber Leanne , Gerard Alison
Published: April 2024

Australia has been widely condemned for its harsh and comprehensive external border controls that seek to control the inward mobility of would-be asylum seekers through visa denial, interdiction and offshore detention. Less widely discussed is the fact that internal controls have been repeatedly ramped up over the past two decades. This includes the administrative removal of lawfully-present non-citizens following visa cancellation on character grounds under s501 of the Migration Act 1958 (Cth). Automatic visa cancellation was introduced in 2014 for non-citizens sentenced to a prison term of 12  months or more, or for certain offences, bypassing individualised decision-making and raising the spectre of a visa cancellation pipeline feeding a highly automated deportation machinery. In an age of increasingly automated forms of governance, a key question that arises is the role that has been played by automated systems in achieving what has been a seismic shift in practice, and the normative implications of any developments towards automation within the visa cancellation and removal systems. This paper outlines the shift towards automation in other systems of governance in Australia—most notably the notorious Robodebt scheme—before examining automation in Australia’s visa cancellation system. Documentary analysis of recent parliamentary inquiries, independent reports and government policy is used to piece together the development of inter-agency data exchange practices and automation over three specific periods—historical practice pre-2014, post-2014 to the present, and proposed future developments. We conclude that Australia’s s501 visa cancellation system is neither automated nor automatic. Rather, the 2014 law reform gave rise to a ‘surveillance fantasy’ with immense consequences for non-citizens, particularly those who face long days in immigration detention at the conclusion of their prison sentence. We show that while concerns about increasing automation are well-founded, systems based on less sophisticated forms of information handling and reliant on human decision-making nevertheless continue to raise age-old questions concerning efficiency, accuracy and fairness.
Source of phosphine on Venus—An unsolved problem
Authors: Bains William , Seager Sara , Clements David L. , Greaves Jane S. , Rimmer Paul B. , Petkowski Janusz J.
Published: April 2024

The tentative detection of ppb levels of phosphine (PH3) in the clouds of Venus was extremely surprising, as this reduced gas was not expected to be a component of Venus’ oxidized atmosphere. Despite potential confirmation in legacy Pioneer Venus mass spectrometry data, the detection remains controversial. Here we review the potential production of phosphine by gas reactions, surface and sub-surface geochemistry, photochemistry, and other nonequilibrium processes. None of these potential phosphine production pathways is sufficient to explain the presence of phosphine in Venus atmosphere at near the observed abundance. The source of atmospheric PH3 could be unknown geo- or photochemistry, which would imply that the consensus on Venus’ chemistry is significantly incomplete. An even more extreme possibility is that a strictly aerial microbial biosphere produces PH3. The detection of phosphine adds to the complexity of chemical processes in the Venusian environment and motivates better quantitation of the gas phase chemistry of phosphorus species and in situ follow-up sampling missions to Venus.
Scope 3: what question are we trying to answer?
Authors: Ballentine Roger
Published: April 2024

Once a little-scrutinized and largely optional aspect of corporate greenhouse gas emissions disclosure, Scope 3 emissions accounting and reporting is now a common element of voluntary climate best practice and is increasingly being adopted as part of new mandatory corporate climate disclosure policies. As Scope 3 disclosure becomes more central to what companies are asked (or required) to do, we perhaps should ask anew what exactly it is we are trying to accomplish. While those NGOs and other stakeholders that designed the Scope 3 framework and who have included it in highly influential corporate leadership programs were well-intentioned, it is becoming clear that the system as designed is ill-suited to serve its fundamental purpose: driving corporate actions to reduce, avoid, and remove greenhouse gas emissions. Scope 3 inventories are often seen as an end in and of themselves, yet from a climate perspective, they are only tools—and only useful if they help lead to positive emissions impact. What companies are asked to do regarding value chain emissions is not adequately aligned with what climate science demands. Therefore, greenhouse gas accounting, disclosure, and leadership programs and rules must modernize their approaches to Scope 3. Options include: limiting data collection requirements to seeking actionable, primary data; using proxy data only as a baseline from which the demonstrated impact of emissions-reducing interventions can be credited by target setting and leadership programs; and by fully embracing the use of verified market mechanisms to enable investments in positive emissions impact.
Biological characteristics and pathogenicity comparison of Nocardia seriolae isolated from Micropterus salmoides and Channa argus
Authors: Zhang Wei , Zhou Kexin , Huang Lei , Yang Na , Lin Lingyun , Chen Lu , Yao Jiayun , Dong Mingxin , Shen Jinyu , Pan Xiaoyi
Published: April 2024

Nocardia seriolae is the primary pathogen causing nocardiosis in various fish species, leads to significant economic losses in the aquaculture industry. In this study, 10 bacterial strains isolated from Micropterus salmoides and Channa argus infected with nocardiosis, were identified as N. seriolae by physiological and biochemical identification, as well as 16S rDNA sequencing. Moreover, the key virulence-related genes such as ESX-1, T7SS-2, T7SS-3, EspG1, sodC, sod2 and ESAT6 were all positive, and showing high homology among different strains. Pathogenicity testing revealed mortality rates ranging from 70 to 100%, accompanied by the presence of white nodules in the viscera of deceased fish. The drug sensitivity test demonstrated that LY21811, the most lethal strain, exhibited high sensitivity to nine types of antibiotics, including azithromycin, doxycycline, florfenicol and compound sulfamethoxazole, yet showed complete resistance to β-lactam antibiotics. Additionally, the tannic acid also demonstrated potent inhibitory effects against LY21811, with a minimum inhibitory concentration of 0.0625 mg/mL. These results showed that N. seriolae originated from M. salmoides and C. argus in Zhejiang Province were highly conserved, demonstrating a high homogeneity in genetic characteristics, pathogenicity and antimicrobial susceptibilities. These results provide a foundation for further research on the pathogenic characteristics and disease prevention of N. seriolae infections.
Intelligent Reduced-Dimensional Scheme of Model Predictive Control for Aero-Engines
Authors: Jiang Zhen , Wang Xi , Liu Jiashuai , Gu Nannan , Liu Wei
Published: April 2024

Model Predictive Control (MPC) has many advantages in controlling an aero-engine, such as handling actuator constraints, but the computational burden greatly obstructs its application. The current multiplex MPC can reduce computational complexity, but it will significantly decrease the control performance. To guarantee real-time performance and good control performance simultaneously, an intelligent reduced-dimensional scheme of MPC is proposed. The scheme includes a control variable selection algorithm and a control sequence coordination strategy. A constrained optimization problem with low computational complexity is first constructed by using only one control variable to define a reduced-dimensional control sequence. Therein, the control variable selection algorithm provides an intelligent mode to determine the control variable that has the best control effect at the current sampling instant. Furthermore, a coordination strategy is adopted in the reduced-dimensional control sequence to consider the interaction of control variables at different predicting instants. Finally, an intelligent reduced-dimensional MPC controller is designed and implemented on an aero-engine. Simulation results demonstrate the effectiveness of the intelligent reduced-dimensional scheme. Compared with the multiplex MPC, the intelligent reduced-dimensional MPC controller enhances the control quality significantly by 34.06%; compared with the standard MPC, the average time consumption is decreased by 64.72%.
Planetary Soil Simulant Characterisation: NU-LHT-2M Study Case to Support Oxygen Extraction Lab Tests with a Low-Temperature Carbothermal Process
Authors: Zanotti Giovanni , Troisi Ivan , Dottori Alice , Lavagna Michèle Roberta
Published: April 2024

Since the landing on the lunar surface, the lunar regolith has begun to interact in different ways with landed elements, such as the wheels of a rover, astronaut suits, drills, and plants for extracting oxygen or manufacturing objects. Therefore, a strong effort has been required on Earth to fully characterise these kinds of interactions and regolith utilisation methods. This operation can only be performed by using regolith simulants, soils that are reproduced with the Earth’s rocks and minerals to match the real features. This article presents the main guidelines and tests for obtaining the properties of a generic simulant in terms of composition, physical and mechanical properties, solid–fluid interaction, and thermal properties. These parameters are needed for the designing and testing of payloads under development for planned lunar surface missions. The same tests can be performed on lunar, martian, or asteroid simulants/soils, both in laboratory and in situ. A case study is presented on the lunar simulant NU-LHT-2M, representative of the lunar highlands. The tests are performed in the context of an in situ resource utilisation (ISRU) process that aims to extract oxygen from the lunar regolith using a low-temperature carbothermal reduction process, highlighting the main regolith-related criticalities for an in situ demonstrator plant.
Improved Re-Parameterized Convolution for Wildlife Detection in Neighboring Regions of Southwest China
Authors: Mao Wenjie , Li Gang , Li Xiaowei
Published: April 2024

To autonomously detect wildlife images captured by camera traps on a platform with limited resources and address challenges such as filtering out photos without optimal objects, as well as classifying and localizing species in photos with objects, we introduce a specialized wildlife object detector tailored for camera traps. This detector is developed using a dataset acquired by the Saola Working Group (SWG) through camera traps deployed in Vietnam and Laos. Utilizing the YOLOv6-N object detection algorithm as its foundation, the detector is enhanced by a tailored optimizer for improved model performance. We deliberately introduce asymmetric convolutional branches to enhance the feature characterization capability of the Backbone network. Additionally, we streamline the Neck and use CIoU loss to improve detection performance. For quantitative deployment, we refine the RepOptimizer to train a pure VGG-style network. Experimental results demonstrate that our proposed method empowers the model to achieve an 88.3% detection accuracy on the wildlife dataset in this paper. This accuracy is 3.1% higher than YOLOv6-N, and surpasses YOLOv7-T and YOLOv8-N by 5.5% and 2.8%, respectively. The model consistently maintains its detection performance even after quantization to the INT8 precision, achieving an inference speed of only 6.15 ms for a single image on the NVIDIA Jetson Xavier NX device. The improvements we introduce excel in tasks related to wildlife image recognition and object localization captured by camera traps, providing practical solutions to enhance wildlife monitoring and facilitate efficient data acquisition. Our current work represents a significant stride toward a fully automated animal observation system in real-time in-field applications.
Concomitant and Bismuth Quadruple Therapy for Helicobacter pylori Eradication in Southern Italy: Preliminary Data from a Randomized Clinical Trial
Authors: Losurdo Giuseppe , Borraccino Antonia Valeria , Aloisio Adriana , Russo Francesco , Riezzo Giuseppe , Galeano Grazia , Pricci Maria , Girardi Bruna , Celiberto Francesca , Iannone Andrea , Ierardi Enzo , Di Leo Alfredo
Published: April 2024

Concomitant therapy (CT) and bismuth quadruple therapy (BQT) are recommended in geographical areas with high clarithromycin resistance for Helicobacter pylori (H. pylori) eradication. We compared CT and BQT as the first lines of treatment in a randomized controlled trial. Consecutive patients with H. pylori diagnosed by concordance of both a urea breath test and histology were recruited. For BQT, patients received 3 PyleraTM capsules q.i.d.; for CT, 1000 mg of amoxicillin b.i.d, 500 mg of clarithromycin b.i.d and 500 mg of metronidazole b.i.d. As a proton pump inhibitor, 40 mg of pantoprazole b.i.d was administered. Both regimens lasted 10 days. In total, 46 patients received CT and 38 BQT. Both groups were comparable for age (p = 0.27) and sex (p = 0.36). We did not record any drop outs; therefore, the intention to treat and per protocol rates coincided. The most common symptoms were heartburn and post-prandial fullness, which were equally present in both groups. The success rate was 95.6% for CT and 100% for BQT (p = 0.56). Side effects were recorded in 23.9% and 31.6% of patients in the CT and BQT arms, respectively (p = 0.47). The most common ones were abdominal pain (8) and diarrhea (6). In conclusion, CT and BQT are equally effective in our area with high clarithromycin resistance, southern Italy, and showed comparable safety.
A Physiological Approach to Explore How Thioredoxin–Glutathione Reductase (TGR) and Peroxiredoxin (Prx) Eliminate H2O2 in Cysticerci of Taenia
Authors: Guevara-Flores Alberto , Nava-Balderas Gabriela , de Jesús Martínez-González José , Vásquez-Lima César , Rendón Juan Luis , del Arenal Mena Irene Patricia
Published: April 2024

Peroxiredoxins (Prxs) and glutathione peroxidases (GPxs) are the main enzymes of the thiol-dependent antioxidant systems responsible for reducing the H2O2 produced via aerobic metabolism or parasitic organisms by the host organism. These antioxidant systems maintain a proper redox state in cells. The cysticerci of Taenia crassiceps tolerate millimolar concentrations of this oxidant. To understand the role played by Prxs in this cestode, two genes for Prxs, identified in the genome of Taenia solium (TsPrx1 and TsPrx3), were cloned. The sequence of the proteins suggests that both isoforms belong to the class of typical Prxs 2-Cys. In addition, TsPrx3 harbors a mitochondrial localization signal peptide and two motifs (-GGLG- and -YP-) associated with overoxidation. Our kinetic characterization assigns them as thioredoxin peroxidases (TPxs). While TsPrx1 and TsPrx3 exhibit the same catalytic efficiency, thioredoxin–glutathione reductase from T. crassiceps (TcTGR) was five and eight times higher. Additionally, the latter demonstrated a lower affinity (>30-fold) for H2O2 in comparison with TsPrx1 and TsPrx3. The TcTGR contains a Sec residue in its C-terminal, which confers additional peroxidase activity. The aforementioned aspect implies that TsPrx1 and TsPrx3 are catalytically active at low H2O2 concentrations, and the TcTGR acts at high H2O2 concentrations. These results may explain why the T. crassiceps cysticerci can tolerate high H2O2 concentrations.
Oxidative Stress and Antioxidant Status in Adult Patients with Transfusion-Dependent Thalassemia: Correlation with Demographic, Laboratory, and Clinical Biomarkers
Authors: Meloni Antonella , Pistoia Laura , Spasiano Anna , Cossu Antonella , Casini Tommaso , Massa Antonella , Bagnato Sergio , Putti Maria Caterina , Maffei Silvia , Positano Vincenzo , Pepe Alessia , Cademartiri Filippo , Vassalle Cristina
Published: April 2024

Iron overload in beta transfusion-dependent thalassemia (β-TDT) may provoke oxidative stress and reduction of the antioxidant defenses, with serious consequences for the disease course and complications. The present study evaluated the oxidant/antioxidant status of β-TDT patients and its correlation with demographic, clinical, laboratory, and instrumental biomarkers. The OXY-adsorbent assay and the d-ROMs (Diacron, Grosseto, Italy) were evaluated in 58 β-TDT patients (mean age: 37.55 ± 7.83 years, 28 females) enrolled in the Extension-Myocardial Iron Overload in Thalassemia Network. Iron overload was quantified with R2* magnetic resonance imaging. Mean OXY was 323.75 ± 113.19 μmol HClO/mL and 39 (67.2%) patients showed a decreased OXY-Adsorbent level (<350 μmol HClO/mL), of whom 22 (37.9%) showed severely reduced levels. Mean d-ROMs was 305.12 ± 62.19 UA; 12 (20.7%) patients showed oxidative stress, and 4 (6.9%) elevated oxidative stress. OXY showed a significant negative correlation with global and segmental cardiac iron levels. D-ROMs levels significantly correlated with markers of cardiovascular risk (aging, glycemia, and N-terminal pro-B-type natriuretic peptide). Antioxidant depletion is frequent in β-TDT patients, where OXY might serve as additive biomarker to assess heart iron status, whereas the d-ROMs might be helpful to assess the cardiovascular risk burden.
Fracture Evolution and Mechanical Properties of Mortar Containing Different Inclusions
Authors: Yao Gang , Wang Guifeng , Tan Lihai , Zhang Yinfeng , Wang Ruizhi , Yang Xiaohan
Published: April 2024

To study the influence of inclusions on the fracture evolution and mechanical properties of mortar structures, a series of uniaxial compression tests for mortar samples containing cylinder inclusions of varying mechanical properties were conducted. The digital image correlation (DIC) technique was employed for the analysis of deformation characteristics. In addition, failure modes for each sample were determined using self-documenting code. The result shows that inclusions filled in holes significantly influence the mechanical properties and failure characteristics of mortar structures as they can change the stress distribution and cracking process. Cracks are typically initiated at the boundaries of the inclusions but will only extend into the inclusion if it is less robust than the surrounding matrix. Sample strength increases significantly with an increase in sample strength when the inclusion’s strength does not surpass that of the surrounding material. Once the inclusion’s strength exceeds that of the surrounding matrix, the strength of the specimen remains relatively unchanged.
Sex-Related and Performance Differences in Contractile Properties, ROM, Strength, and Dynamometry Performance of World-Class Flatwater Canoeists
Authors: Álvarez-Yates Tania , Cuba-Dorado Alba , Iglesias-Caamaño Mario , Serrano-Gómez Virginia , Nakamura Fábio Yuzo , García-García Oscar
Published: April 2024

The inclusion of women canoe in the Olympic Games reflects the growth and development that women have ahead of them in this modality. Therefore, the aim of this study was to explore sex and performance level differences in muscle contractile properties through Tensiomyography (TMG), range of motion (ROM), strength, and canoe-specific functional electromechanical dynamometry (FEMD) performance and establish performance differences between international medalists and non-medalists. Twelve male and nine female canoeists from the Spanish and Portuguese national canoe teams were assessed through TMG, ROM, strength, and canoe-specific isometric and incremental FEMD tests. Few sex and performance level differences were found in TMG and ROM; however, significant sex differences were found in the strength and FEMD tests. Male canoeists had a greater Fmax in Leg Press, Pm and Pmax in canoe position cable row, 1RM bench press and bench pull, Fm and Fpeak canoe-specific isometric FEMD test and number of strokes, and Fpeak and Pmax on the incremental FEMD test than females. International medalists showed a lower time until reaching Vmax and Pmax in Leg Press on both sides and a greater number of strokes and Fpeak in the maximal incremental FEMD test than non-medalists. This study reinforces the utility of the use of TMG and FEMD for assessing and monitoring world-class athletes.
Understanding Forearm Muscle Activity during Everyday Common Grasps: Insights for Rehabilitation, Prosthetic Control, and Human–Machine Interaction
Authors: Jarque-Bou Néstor J. , Vergara Margarita , Sancho-Bru Joaquín L.
Published: April 2024

The specific role of forearm muscles in the development of activities of daily living (ADL) remains unknown. Consequently, studying forearm muscle activity during the most commonly used grasps in ADL would yield valuable insights for hand function evaluation, rehabilitation, and advancements in prosthetic control. In this study, forearm muscle activity was analyzed in 22 healthy subjects, examining seven representative forearm areas during the performance of seven types of grasps at 50% of maximum effort. A Scheirer–Ray–Hare test revealed significant differences for grasp, spot, and their interaction (α < 0.05), but not for repetition (and its interactions). Specific significant differences between grasps were found in specific spots by means of Bonferroni post hoc analyses, ensuring the possibility to discriminate between grasps, which is key to identifying the person’s intention to perform a particular grasp. The median values ranged from 4.4% to 32.8%, depending on the spot and grasp, with small 95% confidence intervals (0.5% to 5.5%). Cylindrical grasp requires the highest muscle activity among all spots, while lateral pinch demands the least. The findings elucidate the contribution, coordination, and function of each muscle in relation to each grasp, with implications for rehabilitation, prosthetics, and telerobotic and teleoperation systems.
EmoStyle: Emotion-Aware Semantic Image Manipulation with Audio Guidance
Authors: Shen Qiwei , Xu Junjie , Mei Jiahao , Wu Xingjiao , Dong Daoguo
Published: April 2024

With the flourishing development of generative models, image manipulation is receiving increasing attention. Rather than text modality, several elegant designs have delved into leveraging audio to manipulate images. However, existing methodologies mainly focus on image generation conditional on semantic alignment, ignoring the vivid affective information depicted in the audio. We propose an Emotion-aware StyleGAN Manipulator (EmoStyle), a framework where affective information from audio can be explicitly extracted and further utilized during image manipulation. Specifically, we first leverage the multi-modality model ImageBind for initial cross-modal retrieval between images and music, and select the music-related image for further manipulation. Simultaneously, by extracting sentiment polarity from the lyrics of the audio, we generate an emotionally rich auxiliary music branch to accentuate the affective information. We then leverage pre-trained encoders to encode audio and the audio-related image into the same embedding space. With the aligned embeddings, we manipulate the image via a direct latent optimization method. We conduct objective and subjective evaluations on the generated images, and our results show that our framework is capable of generating images with specified human emotions conveyed in the audio.
Towards Harnessing the Most of ChatGPT for Korean Grammatical Error Correction
Authors: Park Chanjun , Koo Seonmin , Kim Gyeongmin , Lim Heuiseok
Published: April 2024

In this study, we conduct a pioneering and comprehensive examination of ChatGPT’s (GPT-3.5 Turbo) capabilities within the realm of Korean Grammatical Error Correction (K-GEC). Given the Korean language’s agglutinative nature and its rich linguistic intricacies, the task of accurately correcting errors while preserving Korean-specific sentiments is notably challenging. Utilizing a systematic categorization of Korean grammatical errors, we delve into a meticulous, case-specific analysis to identify the strengths and limitations of a ChatGPT-based correction system. We also critically assess influential parameters like temperature and specific error criteria, illuminating potential strategies to enhance ChatGPT’s efficacy in K-GEC tasks. Our findings offer valuable contributions to the expanding domain of NLP research centered on the Korean language.
Research on Frequency Matching Correction Techniques for South China Precipitation Ensemble Forecast Based on the GRAPES Model
Authors: Dang Jiantao , Zheng Jiawen , Cai Hongke , Zhao Xiaoping , Yang Daoyong , Wang Lianjie
Published: April 2024

This study focuses on the real-time precipitation forecast products of the GRAPES_MESO regional ensemble forecast model, which is developed by the Numerical Weather Prediction Center of the China Meteorological Administration and is initialized 1–3 days in advance at 12:00 UTC. Using a national-level homogenized precipitation grid dataset from surface meteorological stations as observational data, a frequency matching method (FMM) is employed to correct precipitation forecasts for different precipitation intensity levels, including light rain, moderate rain, heavy rain, and torrential rain. Case studies and statistical tests (TS scores) are conducted to compare the forecast performance before and after correction. The results indicate that the model’s Cumulative Distribution Function (CDF) curves deviate from observations, and the longer the lead time, the more significant the error. The correction coefficients (CCs) show an increasing trend with the growth of precipitation intensity, indicating that for larger precipitation amounts and longer lead times, larger CCs are needed, highlighting the necessity of correction. Analyzing two precipitation events in South China in July 2019, the FMM results in an increase in precipitation intensity and a widening of the range of heavy precipitation. The corrected precipitation magnitudes are closer to the observations. The statistical tests using TS scores reveal that the FMM has a certain correction effect on the overall precipitation forecast in the South China region, especially for longer lead times and higher precipitation intensities, where the correction effect is more significant. The necessity of frequency matching correction becomes more apparent for heavier precipitation, and the correction effect becomes more significant with longer lead times.
Using Macrophage Polarization in Human Platelet Lysate to Test the Immunomodulatory Potential of Cells for Clinical Use
Authors: Lopa Silvia , Libonati Francesca , Mareschi Katia , Talò Giuseppe , Brambilla Stefania , Raffo Vincenzo , Labanca Luciana , Zagra Luigi , Moretti Matteo , de Girolamo Laura , Colombini Alessandra
Published: April 2024

Macrophage-based co-cultures are used to test the immunomodulatory function of candidate cells for clinical use. This study aimed to characterize a macrophage polarization model using human platelet lysate (hPL) as a GMP-compliant alternative to Fetal Bovine Serum (FBS). Primary human monocytes were differentiated into unpolarized (M0) or polarized (M1, M2a, and M2c) macrophages in an hPL- or FBS-based medium. The protein secretion profiles and expression of phenotypic markers (CD80 for M1, CD206 for M2a, and CD163 for M2c) were analyzed. Subsequently, chondrocytes were tested in an hPL-based co-culture model to assess their immunomodulatory function in view of their possible use in patients with osteoarthritis. The results showed similar marker regulation between hPL and FBS cultures, but lower basal levels of CD206 and CD163 in hPL-cultured macrophages. Functional co-culture experiments with chondrocytes revealed increased CD206 expression both in hPL and in FBS, indicating an interaction between macrophages and chondrocytes. While markers in FBS-cultured macrophages were confirmed in hPL-cultured cells, the interpretation of marker modulation in immunomodulatory assays with hPL-based cultures should be carried out cautiously due to the observed differences in the basal marker levels for CD206 and CD163. This research underscores the utility of hPL as a GMP-compliant alternative to FBS for macrophage-based co-cultures and highlights the importance of understanding marker expressions in different culture conditions.
Aging’s Effect on Working Memory—Modality Comparison
Authors: Heled Eyal , Levi Ohad
Published: April 2024

Research exploring the impact of development and aging on working memory (WM) has primarily concentrated on visual and verbal domains, with limited attention paid to the tactile modality. The current study sought to evaluate WM encompassing storage and manipulation across these three modalities, spanning from childhood to old age. The study included 134 participants, divided into four age groups: 7–8, 11–12, 25–35, and 60–69. Each participant completed the Visuospatial Span, Digit Span, and Tactual Span, with forward and backward recall. The findings demonstrated a consistent trend in both forward and backward stages. Performance improved until young adulthood, progressively diminishing with advancing age. In the forward stage, the Tactual Span performance was worse than that of the Digit and Visuospatial Span for all participants. In the backward stage, the Visuospatial Span outperformed the Digit and Tactual Span across all age groups. Furthermore, the Tactual Span backward recall exhibited significantly poorer performance than the other modalities, primarily in the youngest and oldest age groups. In conclusion, age impacts WM differently across modalities, with tactile storage capacity being the most vulnerable. Additionally, tactile manipulation skills develop later in childhood but deteriorate sooner in adulthood, indicating a distinct component within tactile WM.
Development and Improvement of a Piezoelectrically Driven Miniature Robot
Authors: Wu Guangping , Wang Ziyang , Wu Yuting , Zhao Jiaxin , Cui Feng , Zhang Yichen , Chen Wenyuan
Published: April 2024

In this paper, we proposed a miniature quadrupedal piezoelectric robot with a mass of 1.8 g and a body length of 4.6 cm. The robot adopts a novel spatial parallel mechanism as its transmission. Each leg of the robot has two degrees of freedom (DOFs): swing and lift. The trajectory necessary for walking is achieved by the appropriate phasing of these two DOFs. A new manufacturing method for piezoelectric actuators was developed. During the stacking process, discrete patterned PZT pieces are used to avoid dielectric failure caused by laser cutting. Copper-clad FR-4 is used as the solder pad instead of copper foil, making the connection between the pad and the actuator more reliable. The lift powertrain of the robot was modeled and the link length of the powertrain was optimized based on the model. The maximum output force of each leg can reach 26 mN under optimized design parameters, which is 1.38 times the required force for successful walking. The frequency response of the powertrain was measured and fitted to the second-order system, which enabled increased leg amplitudes near the powertrain resonance of approximately 70 Hz with adjusted drive signals. The maximum speed of the robot without load reached 48.66 cm/s (10.58 body lengths per second) and the payload capacity can reach 5.5 g (3.05 times its mass) near the powertrain resonance.