bluuebunny/crossref_metadata_2025 huggingface dataset:
Translational Studies Using the MALT1 Inhibitor (S)-Mepazine to Induce Treg Fragility and Potentiate Immune Checkpoint Therapy in Cancer
Authors: Di Pilato Mauro , Gao Yun , Sun Yi , Fu Amina , Grass Carina , Seeholzer Thomas , Feederle Regina , Mazo Irina , Kazer Samuel W. , Litchfield Kevin , von Andrian Ulrich H. , Mempel Thorsten R. , Jenkins Russell W. , Krappmann Daniel , Keller Peter
Published: March 2023

Introduction

Regulatory T cells (Tregs) play a critical role in the maintenance of immune homeostasis but also protect tumors from immune-mediated growth control or rejection and pose a significant barrier to effective immunotherapy. Inhibition of MALT1 paracaspase activity can selectively reprogram immune-suppressive Tregs in the tumor microenvironment to adopt a proinflammatory fragile state, which offers an opportunity to impede tumor growth and enhance the efficacy of immune checkpoint therapy (ICT).

Methods

We performed preclinical studies with the orally available allosteric MALT1 inhibitor (S)-mepazine as a single-agent and in combination with anti-programmed cell death protein 1 (PD-1) ICT to investigate its pharmacokinetic properties and antitumor effects in several murine tumor models as well as patient-derived organotypic tumor spheroids (PDOTS).

Results

(S)-mepazine demonstrated significant antitumor effects and was synergistic with anti-PD-1 therapy in vivo and ex vivo but did not affect circulating Treg frequencies in healthy rats at effective doses. Pharmacokinetic profiling revealed favorable drug accumulation in tumors to concentrations that effectively blocked MALT1 activity, potentially explaining preferential effects on tumor-infiltrating over systemic Tregs.

Conclusions

The MALT1 inhibitor (S)-mepazine showed single-agent anticancer activity and presents a promising opportunity for combination with PD-1 pathway-targeted ICT. Activity in syngeneic tumor models and human PDOTS was likely mediated by induction of tumor-associated Treg fragility. This translational study supports ongoing clinical investigations (ClinicalTrials.gov Identifier: NCT04859777) of MPT-0118, (S)-mepazine succinate, in patients with advanced or metastatic treatment-refractory solid tumors.
Analysis of the Effect of Liquidity and Profitability on Financial Performance at PT. Mayora Indah Tbk
Authors: Ibrahim Ibrahim , Eldi Eldi , Haeruddin Haeruddin
Published: March 2023

This study aims to determine and analyze the effect of liquidity and profitability on financial performance at PT Mayora Indah Tbk. This variable is Liquidity which is proxied by Current Ratio, Profitability which is proxied by Return On Assets (ROA) and financial performance which is proxied by Return On Equity (ROE). Data collection techniques are documentation in the form of financial reports. The data analysis performed was multiple linear regression analysis, classical assumption test and basic statistical test using the SPSS program. Based on the results of the data analysis carried out, the obtained multiple linear equation model Ŷ=0.058-0.026X_1+2.235X_2 which means that liquidity partially has a negative and not significant effect on financial performance with a value of 0.249 > 0.05, profitability partially has a positive and significant effect on financial performance with a value of 0.001 <0.05. Simultaneously liquidity and profitability affect financial performance with a value of 0.004 <0.05.
Theospreneurship dan Cristopreneurhip Sebagai Model Enterpreneur Awam Katekis
Authors: Mbae Veronika
Published: March 2023

Kewirausahaan memiliki potensi untuk mengatasi masalah ini. Dalam landasan teori penulis membahas tentang motivasi berwirausaha, kewirausahaan, faktor pendukung dan penghambat berwirausaha, manfaat berwirausaha, mata kuliah kewirausahaan dan Landasan Alkitabiah yang membahas tentang Theopreneur dari Perjanjian Lama dan Christopreneur pada Perjanjian Baru . Landasan teologis diambil dari dokumen Gaudium Et Spes. Art.34 tentang nilai kegiatan manusia sedangkan landasan pastoral yang mendasari tulisan ini adalah Centesimus Annus Pasal 31 tentang manusia sebagai makhluk Imago Dei dan Laborem Exercens Art. 25 tentang Kerja Manusia. Hipotesis yang dikembangkan secara tertulis adalah rendahnya motivasi berwirausaha di kalangan mahasiswa sehingga penerapan mata kuliah kewirausahaan pada lembaga pendidikan akan meningkatkan motivasi berwirausaha dan melahirkan wirausaha baru yang mampu berpikir kritis, kreatif dan inovatif serta mampu membaca peluang bisnis untuk memulai kegiatan kewirausahaan. Dalam penulisan ini penulis menggunakan model penelitian deskriptif dan pendekatan kualitatif..Berdasarkan hasil analisis data wawancara penulis mengetahui bahwa pemahaman siswa tentang kewirausahaan, faktor-faktor yang mendukung kegiatan kewirausahaan sudah sangat baik tetapi motivasi untuk berwirausaha masih rendah karena faktor penghambat seperti malas, tidak mau mengambil resiko, tidak ada kemauan dari dalam diri, takut mengalami kegagalan, modal yang terbatas, sumber daya manusia yang rendah, kurangnya pengalaman praktis, kurangnya kesempatan
Healthcare Resource Utilization and Costs Among Patients With Gastroesophageal Reflux Disease, Barrett’s Esophagus, and Barrett’s Esophagus-Related Neoplasia in the United States
Authors: Sharma Prateek , Falk Gary W. , Bhor Menaka , Ozbay A. Burak , Latremouille-Viau Dominick , Guerin Annie , Shi Sherry , Elvekrog Margaret M. , Limburg Paul
Published: March 2023

Background: Gastroesophageal reflux disease (GERD) is a risk factor for Barrett’s esophagus (BE) and BE-related neoplasia (BERN).

Objectives: This study aimed to evaluate healthcare resource utilization (HRU) and costs associated with GERD, BE, and BERN in the United States.

Methods: Adult patients with GERD, nondysplastic BE (NDBE), and BERN (including indefinite for dysplasia [IND], low-grade dysplasia [LGD], high-grade dysplasia [HGD] or esophageal adenocarcinoma [EAC]), were identified from a large US administrative claims database, the IBM Truven Health MarketScan® databases (Q1/2015-Q4/2019). Patients were categorized into the corresponding mutually exclusive EAC-risk/diagnosis cohorts based on the most advanced stage from GERD to EAC using diagnosis codes in medical claims. Disease-related HRU and costs (2020 USD) were calculated for each cohort.

Results: Patients were categorized into the following EAC-risk/diagnosis cohorts: 3 310 385 into GERD, 172 481 into NDBE, 11 516 into IND, 4332 into LGD, 1549 into HGD, and 11 676 into EAC. Disease-related annual mean number of inpatient admissions, office visits, and emergency department visits by cohort were 0.09, 1.45, and 0.19 for GERD; 0.08, 1.55, and 0.10 for NDBE; 0.10, 1.92, and 0.13 for IND; 0.09, 2.05, and 0.10 for LGD; 0.12, 2.16, and 0.14 for HGD; and 1.43, 6.27, and 0.87 for EAC. Disease-related annual mean total healthcare costs by cohort were $6955 for GERD, $8755 for NDBE, $9675 for IND, $12 241 for LGD, $24 239 for HGD, and $146 319 for EAC.

Discussion: Patients with GERD, BE, and BERN had important HRU and costs, including inpatient admissions and office visits. As patients progressed to more advanced stages, there was substantially higher disease-related resource utilization, with associated costs being 16 times higher in patients with EAC than those with NDBE.

Conclusions: Findings suggest the need for early identification of high-risk individuals prior to progression to EAC to potentially improve clinical and economic outcomes in this population.
Healthcare Resource Utilization and Costs Among Patients With Gastroesophageal Reflux Disease, Barrett’s Esophagus, and Barrett’s Esophagus-Related Neoplasia in the United States
Authors: Sharma Prateek , Falk Gary , Bhor Menaka , Ozbay A. Burak , Latremouille-Viau Dominick , Guerin Annie , Shi Sherry , Elvekrog Margaret , Limburg Paul
Published: March 2023

Background: Gastroesophageal reflux disease (GERD) is a risk factor for Barrett’s esophagus (BE) and BE-related neoplasia (BERN). Objectives: This study aimed to evaluate healthcare resource utilization (HRU) and costs associated with GERD, BE, and BERN in the United States. Methods: Adult patients with GERD, nondysplastic BE (NDBE), and BERN (including indefinite for dysplasia [IND], low-grade dysplasia [LGD], high-grade dysplasia [HGD] or esophageal adenocarcinoma [EAC]), were identified from a large US administrative claims database, the IBM Truven Health MarketScan® databases (Q1/2015-Q4/2019). Patients were categorized into the corresponding mutually exclusive EAC-risk/diagnosis cohorts based on the most advanced stage from GERD to EAC using diagnosis codes in medical claims. Disease-related HRU and costs (2020 USD) were calculated for each cohort. Results: Patients were categorized into the following EAC-risk/diagnosis cohorts: 3 310 385 into GERD, 172 481 into NDBE, 11 516 into IND, 4332 into LGD, 1549 into HGD, and 11 676 into EAC. Disease-related annual mean number of inpatient admissions, office visits, and emergency department visits by cohort were 0.09, 1.45, and 0.19 for GERD; 0.08, 1.55, and 0.10 for NDBE; 0.10, 1.92, and 0.13 for IND; 0.09, 2.05, and 0.10 for LGD; 0.12, 2.16, and 0.14 for HGD; and 1.43, 6.27, and 0.87 for EAC. Disease-related annual mean total healthcare costs by cohort were $6955 for GERD, $8755 for NDBE, $9675 for IND, $12 241 for LGD, $24 239 for HGD, and $146 319 for EAC. Discussion: Patients with GERD, BE, and BERN had important HRU and costs, including inpatient admissions and office visits. As patients progressed to more advanced stages, there was substantially higher disease-related resource utilization, with associated costs being 16 times higher in patients with EAC than those with NDBE. Conclusions: Findings suggest the need for early identification of high-risk individuals prior to progression to EAC to potentially improve clinical and economic outcomes in this population.
Tratamento tópico de ácido hialurônico 0,2% associado ao laser em baixa intensidade em queimadura de segundo grau.
Authors: Pereira Gardino Joceli , Masson Valéria Aparecida , Neves da Silva Marilene , Vieira-Damiani Gislaine , Gonçalves de Oliveira Pedro , Castilho João Cezar
Published: March 2023

Objetivo: Descrever por meio de relato de experiência profissional o uso tópico de ácido Hialurônico 0,2% (Hyaludermin®) associado ao Laser de Baixa Intensidade (LBI) na cicatrização de queimadura de segundo grau. Método: Trata-se de relato de experiência profissional por meio de atendimento autônomo por enfermeiras especialistas dermatoterapeutas. Este estudo descreve o protocolo de tratamento aplicado em lesão por queimadura de segundo grau em uma paciente de 64 anos, que sofreu queimadura por escaldadura de panela de pressão. Foi realizado registro fotográfico e a avaliação da ferida observando-se as variáveis de tempo de cicatrização, surgimento de cicatrização inestética e o efeito estético final. Resultados: Inicialmente, foi realizado protocolo de tratamento com a com sulfadiazina de prata 1% associado LBI vermelho 1J no leito da lesão e Infravermelho 2 J na área adjacente. Como não houve resolução, iniciou-se o tratamento com ácido hialurônico (AH) 0.2% diariamente com manutenção do protocolo de LBI. Após 21 dias de tratamento, observou-se completa cicatrização da lesão. O tratamento tópico com AH 0.2% foi mantido sobre a área reepitelizada. A cicatriz apresentou-se com melhora de hiperpigmentação de cicatrização inestética. Conclusão: A aplicação tópica de AH 0,2% em associação com LBI em queimadura trouxe como benefícios a redução do tempo de cicatrização, e o resultado estético final.
Determinantes da assistência materno-infantil segura a luz de evidências cientí­ficas: uma revisão integrativa
Authors: Padovani Camila , Pomin Frutos da Silva Juan , Silva Dantas Letí­cia , Karina Rissardo Leidyani , Benatti Antunes Marcos , Marisa Pelloso Sandra
Published: March 2023

Objetiva-se identificar fatores que promovam falhas no cuidado obstétrico e comprometam a segurança da gestante edo bebê. Trata-se de uma revisão integrativa, realizada nas bases de dados: MEDLINE, LILACS, BDENF, no perí­odo de janeiro de 2006 a janeiro de 2016 com uso das palavras-chaves: "enfermagem", "segurança do paciente", "obstetrí­cia" e "maternidade". Foram selecionados oito estudos elegí­veis. A análise dos artigos resultou nas categorias: Comunicação interpessoal e trabalho em equipe no cuidado obstétrico e práticas e condutas que afetam a assistência segura í  saúde materna e perinatal. Conclui-se que para um cuidado seguro, é necessário cuidados respaldados pelas técnicas fundamentadas na literatura em conjunto ao comprometimento profissional e visão holí­stica do paciente, para que possa oferecer uma assistência materno-infantil segura.
FEATURES OF PHYSICAL TRAINING OF FUTURE LAW ENFORCEMENT SPECIALISTS
Authors:   Donetsk State University of Internal Medicine affairs, Galimskyi Volodymyr
Published: March 2023

This article reveals the main problems of the process of physical and special training in higher educational institutions of the Ministry of Internal Affairs, outlines ways to solve these problems (combination of general and special physical training, use of elements of high sports technologies in the educational process, which are based on modern achievements of sports theory), the introduction of which to the existing system of training future law enforcement officers will positively affect their professional development as highly qualified professionals of the National Police of Ukraine of a modern European country. A modern policeman must ensure the safety of people, using, if necessary, sufficient force means and methods; able to distinguish dangerous situations; under any circumstances to act without prejudice, guided by ethical standards. The analysis of the practice of law enforcement confirms that the functional duties of a police officer can be performed by a person with a high level of responsibility for the results of his own official activity, who possesses a complex of knowledge, practical skills and formed professionally important traits acquired during special training. It is these components that ensure the professional readiness of a police officer to effectively perform complex, sometimes dangerous tasks. The new concept of activity of the National Police of Ukraine requires a special creative activity, a high level of culture, education, the ability for self-development and self-improvement from a law enforcement officer. Under such conditions, increasing the level of professional readiness of police officers is a key area of activity of higher education institutions of the Ministry of Internal Affairs of Ukraine and professional training departments of the National Police units. A thorough analysis of the domestic and foreign experience of training police officers gives reason to state that each country has developed its own approaches to solving the problem of professional training of police personnel. On the basis of the conducted research on the identification of specifics and actual problems in the process of training future law enforcement officers, it is possible to conclude about the need to improve the existing system and introduce innovative approaches that will positively affect their preparedness. It was determined, firstly, that the main problem is the low level of physical fitness of young people who join the armed forces, which creates certain difficulties in learning special and professional-applied skills. Secondly, the lack of a single standard program for physical and special training in institutions of higher education of the Ministry of Internal Affairs of Ukraine and a decrease in the number of hours per discipline. Thirdly, the youth's motivation for physical training is low.
STEPANIVNA THE FORMATION OF LEADERSHIP QUALITIES OF EDUCATION ACQUISITIONS IN THE EDUCATIONAL PROCESS OF HALL SECONDARY EDUCATION INSTITUTIONS
Authors:   Chernivtsi Yuriy Fedkovych National University, Yemchuk Tetiana , Chubrei Oleksandra ,   Chernivtsi Yuriy Fedkovych National University
Published: March 2023

In modern conditions of growth of all spheres of social life in Ukraine, the problem of leadership becomes especially urgent, because society needs leaders who are able to unite people around them to achieve the set goal and contribute to its moral development. Despite the significant development of the topic of leadership in general, at the same time, scientific research lacks diagnostics and means of forming communicative and leadership qualities in students of general secondary education institutions. The article analyzes the formation of leadership qualities of students in the educational process of general secondary education institutions. Emphasis is placed on society's need for sociable leadership personalities that must be nurtured from childhood. After all, who this person will become in the future depends on the upbringing process. Therefore, the topic of leadership attracts the attention of representatives of various directions. Research on the education of leadership qualities of an individual does not give a holistic view of the project activity of education of these qualities. The main qualities of a leader include: responsibility, demandingness in the performance of work in relation to oneself and people; honesty before oneself and people; empathy (to feel empathy); able to influence others; communicativeness; organized in any spheres of life; is able to demonstrate a personal example in behavior and activity; self-confidence; able to manage himself and his own emotions; ready to make responsible decisions. Special attention should be paid to the analysis of diagnostics of communicative and organizational abilities according to the method of V.V. Sinyavskyi and B.O. Fedoryshyn The communicative and organizational abilities of higher education students were investigated and identified, which include the rapid establishment of relationships between people, the establishment of business contacts, their participation and involvement in public and group events, initiative, the ability to take responsibility and influence people or the group as a whole. directs their activities in a certain direction, which contributes to the achievement of common goals.
METHODS OF FORMING SELF-IMPROVEMENT SKILLS IN FUTURE IT SCIENTISTS USING INFORMATION TECHNOLOGIES
Authors:   Volodymyr Vynnychenko Central Ukrainian State Pedagogical University, Kapitan Tetiana
Published: March 2023

The article deals with continuous personal and professional self-improvement of the specialists in the field of information technologies and pedagogical conditions as the development and formation of versatile aspects of professional training of the future specialists. The specificity of pedagogical activity arises from the fact that it combines organizational, research and creative components, therefore, in modern pedagogical conditions, it is important to be able to actively perceive new things, ensuring the continuity of personal and professional self-improvement. For higher pedagogical educational institutions, the primary task is the formation of the future teacher personality who is able to be constantly engaged in the personal and professional self-improvement, ready for continuous education, that is, for regular self-development. The development of readiness for self-improvement of future specialists in the field of information technologies is a rather complex process, the effectiveness of which depends on the implementation and observance of the necessary pedagogical conditions. Usually, pedagogical conditions are interpreted as those that are specially created in the educational process to increase its efficiency or implement innovations. The issue of qualification of pedagogical conditions has become the subject of attention of many researchers. We consider the analysis of a number of scientific works in which the pedagogical conditions of development and formation of versatile aspects of professional training of future specialists are considered important for our exploration of the features of the development of self-improvement skills of future specialists by means of information technologies. The personal self-improvement, which begins at school, should continue life-long. The professional self-development is a complex, multifaceted, continuous, conscious process aimed at the formation, integration and implementation of professionally significant personal traits, professional knowledge, abilities and skills in the professional activities. The future specialists are creative individuals who constantly have many new ideas and are ready to accept innovations in education. After all, the teacher must regularly prepare new, interesting lectures, be able to adapt to changes in the educational process. Modern student teachers have to master a variety of educational technologies. In the professional activity of the teacher, a structural component is the professionalism of self-improvement.
PROBLEM OF PRESERVING AND STRENGTHENING CHILDREN'S HEALTH: HISTORICAL AND PEDAGOGICAL DISCOURSE
Authors:   Judo Federation of Ukraine, Koshliak Mykhailo
Published: March 2023

Solving the problem of preserving and strengthening the health of the younger generation is directly dependent on the resolution of the contradiction between the social requirements to raise healthy younger Ukrainians and the insufficient capabilities of educational institutions for their effective and purposeful implementation. Under such conditions, there is a growing need for a systematic retrospective analysis, a constructive rethinking of the knowledge accumulated by pedagogical science on the problem of preserving and strengthening the health of the younger generation. The article examines the problem of preserving and strengthening children's health in the historical-pedagogical discourse. It was found that J. J. Rousseau paid considerable attention to the problem of children's health. In his writings, he advocated natural education, its transformation into an active, optimistic process, when a child lives in joy, independently learning about the world, being spiritually enriched and satisfying the thirst for knowledge. The French teacher S. Frenet believed that it is necessary to take into account the peculiarities of age psychology and various abilities and inclinations of students, purposeful stimulation of their intellectual and emotional activity. In his writings, K. Ushinskyi proves that an important task of teachers is to care for the preservation and strengthening of children's health, compliance with hygienic requirements at school. A. Makarenko and V. Sukhomlynskyi were given a special role in the issue of improving the health of students, instilling hygienic skills in children, preventing mental fatigue, observing the regime of work and rest. G. Vashchenko left a valuable pedagogical legacy regarding children's health care through involvement in sports. It has been established that the study of the place of physical education in Ukrainian scientific and pedagogical thought is an urgent problem today, when complex processes in the educational and educational sphere are taking place in the state. The legacy of teachers left to us is interesting from the point of view of psychological and pedagogical heritage, idealistic worldview, principles of a healthy lifestyle, education of a healthy young generation, etc., which are based on the worldview of scientific ideas.
THE ESSENCE OF THE PHENOMENON OF PUBLIC AND PRIVATE-BASED UNIVERSITY GOVERNANCE IN THE CONTEXT OF ENSURING THE EFFECTIVENESS OF EDUCATIONAL ACTIVITIES
Authors:   National Academy of Educational Sciences of Ukraine, Borodiyenko Oleksandra
Published: March 2023

The article defines the essence of the phenomenon of public and private-based university governance and for the first time substantiates the concept of "public and private-based university governance in the context of ensuring the effectiveness of educational activities." Based on the algorithm of definition of concepts (definition of the list of essential features of a concept; definition of a concept through the nearest genus; definition of a concept through its specific features) and analysis of a set of related concepts ("public administration", "public governance", "public and state governance", "state and public governance", "public control", "public-state partnership", "public-private partnership", "social partnership", "tripartite partnership", "partnership-based governance") the author's definition of public and private-based university governance in the context of ensuring the effectiveness is presented. It was substantiated that public and private-based university governance in the context of ensuring the effectiveness is a process of managing cooperation between various entities (state and private sector, institutions of civil society) on the basis of a combination of democratic procedures of self-management and cooperation aimed at increasing the efficiency and effectiveness of universities, creating their comparative advantages through the rational distribution of responsibilities and supplementing the resource provision of partners, increasing the level of managerial and economic capacity and viability, adaptation to rapidly changing environmental conditions, ensuring sustainable development and dissemination of innovations, creation of an innovative ecosystem. Prospects for further research in the field are presented - the study of Ukrainian and foreign experience and best practices of public and private-based university governance, substantiation of its theoretical foundations (principles, regularities, organizational conditions, models, etc.).
DEVELOPMENT PROSPECTS OF MODERN BALLROOM DANCES
Authors:   Volodymyr Vynnychenko Central Ukrainian State Pedagogical University, Spinul Ihor , Spinul Helen ,   Volodymyr Vynnychenko Central Ukrainian State Pedagogical University
Published: March 2023

Today, modern ballroom dance is the priority direction of the development of modern choreographic art, in contrast to folk and pop art. Nowadays, despite the existence of a sufficiently large number of different directions of modern, folk, pop choreography, ballroom dance is becoming not only more and more popular, but also a dynamically developing direction. Therefore, special attention from the point of view of both historical and theoretical-methodical research of ballroom dance requires substantiation of its features and prerequisites for further development, both as a sport and as a choreographic art. The article examines the conditions for the formation of ballroom dancing, its main features, and determines the prospects for the further development of this type of choreographic art. Dance provides an opportunity for physical, aesthetic, spiritual development and education of both children and youth, as well as adults. Learning the best motor skills and skills in the training process is associated with the mobilization and active development of many physiological functions of the human body: blood circulation, breathing, neuromuscular activity, etc. Thanks to the fast rhythm, complex and varied technique, ballroom dancing helps a person to feel self-confidence, prevents the appearance of complexes, trains endurance, the vestibular apparatus, the respiratory system and the heart. In recent years, a new type of leisure activity in the field of ballroom dancing has been actively developing in Ukraine - dancing in the Pro-Am (Professional - amateur) format. Pro-Am is a direction in ballroom dancing where one participant is a professional teacher and the other is an amateur student. In addition to numerous trainings in the dance hall and demonstration performances, such a couple has the opportunity to participate in dance tournaments and festivals. Pro-Am competitions are held both as part of sports ballroom dance tournaments and as independent events. The Pro-Am system is a unique dance training system. An individual approach to each student makes it possible not only to teach him to dance technically correctly, but also to reveal individual capabilities. Everyone who studies has the opportunity to choose the direction that he likes the most and to study in the mode that suits him best, thus, the effectiveness of classes increases.
The results of the evaluation of the international testing “Acute reactions in children” among doctors of various specialties
Authors: Pampura Alexander N. , Esakova Natalia V. , Dolotova Daria D. , Zakharova Irina N. , Plavunov Nikolai F. , Lekmanov Andrey U. , Kadyshev Valeriy A.
Published: March 2023

BACKGROUND: Anaphylaxis is a situation at risk of death; thus, doctors should identify its symptoms and provide emergency assistance.
AIMS: This study aimed to conduct a comparative analysis of the level of knowledge on anaphylaxis in children among doctors of various specialties.
MATERIALS AND METHODS: The study was conducted anonymously using an online questionnaire (Google Forms) among five groups of doctors: allergologists-immunologists, resuscitators-anesthesiologists, emergency physicians, pediatricians, and students of accredited university graduates. The questionnaire included six tasks on anaphylaxis in children and four tasks on other diseases similar to anaphylaxis, and each had two questions (diagnosis and treatment) with three answer options; if one was correct, 1 point was given.
RESULTS: A total of 1871 respondents from nine countries filled out the questionnaire correctly. The average score of the allergists on anaphylaxis tasks was the highest (9 of 12 points) in comparison with other groups (p 0.001). The average score on non-anaphylaxis tasks was high in all groups (7 of 8 points). The level of knowledge of respondents did not correlate with age and work experience. In anaphylaxis tasks, allergists made the appropriate diagnosis in 83.7% of cases; resuscitators, pediatricians, and students in 2/3; and emergency physicians in 50%. For the treatment of anaphylaxis, allergists prescribed epinephrine in 66.7% of cases, and other groups in 50%. The percentage of correct answers in the tasks of food anaphylaxis (diagnosis) was the highest among allergists (8096%), compared with other groups (3682%) (p 0.001). In the treatment of food anaphylaxis, allergists prescribed epinephrine more often (up to 85%) than other groups (up to 77%). The percentage of correct responses of drug anaphylaxis among all groups was high; however, resuscitators responded better (diagnosis, 94%; treatment, 64%). All groups had the lowest level of knowledge on idiopathic anaphylaxis.
CONCLUSIONS: Anaphylaxis can be underdiagnosed in 50% of pediatric cases; however, even with correct diagnosis, epinephrine is not prescribed in half of the cases. Thus, increasing and maintaining the level of knowledge on anaphylaxis among doctors of various specialties, regardless of their length of service, are necessary.
Family Support and The Role of Health Professionals on Parent’s Perspectives of Covid-19 Vaccination in Child
Authors: Nurdiyan Ayu , Susanti Evi
Published: March 2023

Background: The administration of Covid-19 immunization is one of the measures taken to prevent Covid-19 infectious diseases among vulnerable groups, such as children aged 6 to 11 years. However, the majority of parents continue to have a poor opinion of the safety of the Covid-19 vaccine and its side effects, since just 5.7% of parents of 564,833 children in West Sumatra allow their children to get vaccinated.
Purpose: This study aimed to investigate the determinants of parents’ perception towards vaccinating their children against COVID-19.
Methods: This study employed a quantitative methodology and a Cross Sectional design. This research was conducted at an elementary school in Bukittinggi. The study population consisted of 466 children. In this study, 100 respondents were consecutively selected as samples. The tool employed was a valid and reliable questionnaire, and the data were analyzed using a chi-square test with a significance level of 0.05.
Results: the results of the statistical test of bivariate analysis stated that there was a relationship between family support and perspective, p Value 0.05 (< 0.05), and there was no relationship between the role of health workers and perspective p Value 0.318 (> 0.05).
Conclusion: it is important to increase the positive perspective of parents regarding vaccination, this can be done through health promotion by using various media so that not only parents get but also increase the perception of family support.
Analysis of Red Betel Leaf Tests As A Natural Anti-Infection In Post Partum Mothers
Authors: Fratidhina Yudhia , Mulyati Sri , Astri Hetty , Maximus Silvester
Published: March 2023

Background: Incidence of infection contributes to maternal mortality. Innovative efforts to treat infection in postpartum mothers continue to be made, including non-pharmacological techniques. The local wisdom of red betel leaves is believed by the community to be able to handle it. The true efficacy of this extraordinary red betel leaf deserves further investigation. The purpose of this study was to assess the effectiveness of red betel on perineal wound healing in postpartum mothers.
Methods: This study used the Quasi Experiment with Control Group Design method. The study was conducted on 80 postpartum mothers with perineal wounds degrees 1 to 3. 40 women were included in the intervention group who were given red betel ointment made by researchers from 2 hours to 7 days postpartum. 40 people as the control group were given perineal wound care according to standard. Assessment of wound healing was carried out every day until the 7th day postpartum. Statistical tests used the dependent and independent t-tests to examine differences in healing scores in the two study groups.
Results: There was an increase in the average perineal wound healing value in the intervention group which was higher and there was an increase in the average healing value every day, starting from the first day (mean = 9.25), the second day (mean = 11.55), and the seventh day (mean = 12.65) compared to the control group, p value <0.001. On the third day postpartum, the intervention group had the maximum healing value (100%) compared to the control group (52.5%)
Influence of Consuming Honey on The Eating Frequency of Children Under Five Years (3-5 Years)
Authors: Ratnaningrum Asti , Wulandari Siswi
Published: March 2023

Background: Children under five (0-5 years) have a very high level of brain plasticity so they will be more open to learning and enrichment processes. A study in Jakarta found that preschool children aged 4-6 years have a prevalence of eating difficulties of 33.6% and most of them (79.2 have lasted more than 3 months.
Purpose: To determine the influence of consuming honey on eating frequency in children aged 3-5 years.
Method: This pre-experimental study used one group pretest-posttest design. This study involved 34 children aged 3-5 years determined using the simple random sampling technique. The variable measured was the consumption of honey as the independent variable, while the dependent variable was the frequency of eating before and after consuming honey. The statistical test used in this study was the Wilcoxon statistical test with a 95% confidence level (? = 0.05). The Statistic Analyses used to SPSS V.26.
Results: The results showed that 26 children (76.5%) ate less than three times a day before consuming honey and 18 children (52.9%) have a frequency of eating more than three times a day after consuming honey.. The result of the bivariate test was 0.000 which is lower than 0.05.
Conclusion: Consuming honey influence the frequency of eating of children aged 3-5 years. It is expected that the results of this study can enrich knowledge on the benefits of honey so that respondents can better understand and apply it at home to their children.
Declaración de Ética
Authors: Gonzalez Beltrones Adria Velia
Published: March 2023

El Código de Ética de Biolex Revista Jurídica del Departamento de Derecho se finca en los valores instituidos por la legislación que rige a la Universidad de Sonora,1donde se distinguen por su preponderancia, valores como la honestidad, el respeto y tolerancia, responsabilidad social, ética, responsabilidad, solidaridad, justicia, autonomía, equidad, compromiso con la naturaleza, libertad de cátedra e investigación, que enmarcan el quehacer y la responsabilidad académica y científica de los colaboradores de Biolex. También se adhiere a las Convenciones Nacionales e Internacionales en materia de Derechos de Autor suscritas por la Organización Mundial de la Propiedad Intelectual,2 a la que pertenece México.
On the Order of Convergence and the Dynamics of Werner-King's Method
Authors: George Santhosh , Argyros Ioannis K. , Kunnarath Ajil , Jidesh Padikkal
Published: March 2023

In this paper, we present the local convergence analysis of Werner-King's method to approximate the solution of a nonlinear equation in Banach spaces. We establish the local convergence theorem under conditions on the first and second Fréchet derivatives of the operator involved. The convergence analysis is not based on the Taylor expansions as in the earlier studies (which require the assumptions on the third order Fréchet derivative of the operator involved). Thus our analysis extends the applicability of Werner-King's method. We illustrate our results with numerical examples. Moreover, the dynamics and the basins of attraction are developed and demonstrated.
An efficient Feed-forward compensation mechanism for NFC-based PMSM system using different observers for Load-torque estimation
Authors: M.S Parvathy Thampi , Raghavendra N G.
Published: March 2023

Permanent magnet synchronous motor (PMSM) offers high torque and efficiency and is used in most industrial applications. This manuscript uses a feed-forward compensation mechanism to design an efficient neuro-fuzzy logic controller (NFC) based surface-mounted PMSM system. The different load-observers like Discrete Luenberger Observer (DLO), Kalman filter observer (KFO), and discrete Kalman filter observer (DKFO) are used as a feed-forward compensation method to compensate the dq stator current and also estimate performance metrics. The NFC is used as a speed controller, and two PI controllers are used for the current control mechanism. The noise is added at the actual load torque and speed of PMSM and compensated using load observers. In this work, two different design scenarios are considered to analyze the performance metrics like load torque, speed, and position. The work also explores the average error that occurred at load torque, speed, and position during estimation. The NFC-based PMSM system improves the performance and utilizes less error over the PI/FLC-based PMSM using different observers.
A Systematic Approach of Advanced Dilated Convolution Network for Speaker Identification
Authors: Pentapati Hema Kumar , K Sridevi
Published: March 2023

Over the years, the Speaker recognition area is facing various challenges in identifying the speakers accurately. Remarkable changes came into existence with the advent of deep learning algorithms. Deep learning made a remarkable impact on the speaker recognition approaches. This paper introduces a simple novel architectural approach to an advanced Dilated Convolution network. The novel idea is to induce the well-structured log-Melspectrum to the proposed dilated convolution neural network and reduce the number of layers to 11. The network utilizes the Global average pooling to accumulate the outputs from all layers to get the feature vector representation for classification. Only 13 coefficients are extracted per frame of each speech sample. This novel dilated convolution neural network exhibits an accuracy of 90.97%, Equal Error Rate(EER) of 3.75% and 207 Seconds training time outperforms the existing systems on the LibriSpeech corpus.
Enhancement of Voltage Regulation and Transient Stability of Six Phase STATCOM using Decoupled Current Control Strategy
Authors: Nakka Srinivas , Brinda R. , Sairama T.
Published: March 2023

STATCOM is used in a six-phase transmission system to improve voltage regulation and transient stability. Six-phase pulse width modulated voltage source converters are used in the design of STATCOM, and a decoupled current control approach is used to operate it. The voltage references used by the voltage source converters' pulse generator are produced using a decoupled control method. This control technique allows for the decoupling of the coupling effect or the dependence of the d and q currents on one another, which improves system performance under unusual and abnormal conditions. By using the pulse generator of voltage source converters, the inner current control loop and the outer voltage control loop are intended to produce the necessary reference voltages. Simulation results are presented using MATLAB/SIMULINK to check efficacy of proposed six phase STATCOM.
Modelling and Simulation of MPPT Based Solar Photovoltaic System for Voltage Lift LUO Converter
Authors: Ananth S. Vijai , Singaravelu S.
Published: March 2023

Several maximum PowerPoint tracking techniques have been proposed to achieve optimal matching between solar photovoltaic arrays to load for extracting maximum available power from photovoltaic source. These techniques differ in terms of tracking speed, complexity, cost, accuracy of tracking, number of sensors used etc., This article proposes an Adaptive Neuro Fuzzy-Inference System (ANFIS) based maximum PowerPoint tracking for positive-output voltage lift LUO converter based on solar (PV)system for resistant load application. Performance analysis of proposed (MPPT) technique has been evaluated in MATLAB/Simulink environment for four different cases of input radiation and temperature patterns. These test input patterns have been chosen based on European standard EC50530.Simulation results revealed that proposed ANFIS maximum PowerPoint tracking technique effectively captures the maximum PowerPoint in a faster way with good accuracy under both steady state and dynamic climatical conditions. Moreover, a comparative study has been presented between conventional (P & O) -technique and proposed ANFIS MPPT technique. Comparative study reveals that ANFIS MPPT technique has higher tracking efficiency with lesser tracking time without any oscillation around maximum power point.
VARIATIONAL ANALYSIS OF A VISCOELASTIC FRICTIONAL CONTACT WITH LONG-TERM MEMORY BODY WITH THERMAL EFFECTS
Authors: Sidhoum K. , Merouani A.
Published: March 2023

In this article we study a mathematical model which describes the quasi-static process of contact between a piezoelectric body with long-term memory and an obstacle. The contact is modeled with a normal conformity condition and a version of Coulom's law. The evolution of temperature is described by a first kind evolution equation. The problem is formulated as a system of scalable elliptical variational inequalities for displacement, and a variational equality for electrical stress. We prove the existence of a unique weak solution to the problem. The proof is based on arguments from time-dependent variational inequalities, differential equations and fixed point.
Esportes de Combate: Estudo sobre Comportamento Alimentar Inadequado e Insatisfação Corporal
Authors: Loula Bruna Maria Amorim , Santana Mayara , Silva Alves Anne Caroline , Rodrigues Ariana Tito , Reis Belini Alessandra Pricila Dos , Saldiba De Lima Adriana Machado
Published: March 2023

Objetivo: Avaliar a presença de sintomas de TA e o grau de satisfação corporal em praticantes de luta do sexo masculino das modalidades: muay thai, taekwondo e judô. Metodologia: Foi realizada uma pesquisa descritiva quantitativa com 36 praticantes (12 atletas de muay thai, 5 de taekwondo e 19 de judô) do sexo masculino. Foi aplicado Questionário de Informações Gerais, Escala de Atitudes Alimentares (EAT-26), Body Shape Questionnaire (BSQ) e a Escala de Silhuetas de Kakeshita para homens. Resultados: A média de idade dos atletas foi de 31 anos, com Índice de Massa Corpórea (IMC) médio de 27,3 kg/m² e a maior parcela da  amostra (52,7%) pratica judô. Houve correlação positiva entre o valor de IMC com os escores do EAT-26 (p < 0,05; r = 0,36), com o BSQ (p = 0,001; r = 0,54) e com a insatisfação corporal houve correlação negativa (p < 0,001; r = - 0,77), o que denota que quanto maior o IMC, maior a insatisfação corporal. Não houve correlação entre preferência e  utilização de vestuário com EAT-26 e BSQ entre os participantes. Discussão: Não apresentam, em média, comportamento alimentar de risco. Os valores de BSQ indicam preocupação leve com a aparência enquanto a IC (-1,61 + 2,4), avaliada pela Escala de Silhuetas de Kakeshita indica um desejo de diminuir o tamanho corporal. Conclusão: Os praticantes desejam emagrecer e o escore médio de preocupação com aparência evidencia uma leve apreensão destes com seus corpos, dado que os valores de IMC gerais indicaram sobrepeso. É importante destacar a ação multidisciplinar para estas desordens, visto que o tratamento de TA e questões ligadas a IC englobam fatores nutricionais e biológicos, implicando na análise das relações sociais, na percepção deste individuo na construção de sua autoimagem.
Comparação Do Nível De Atividade Física E Qualidade De Vida De Crianças E Adolescentes Com Deficiência Física
Authors: Silva Fernanda Carolina Toledo da , Ferreira José Pedro , Braccialli Lígia Maria Presumido
Published: March 2023

O nível de atividade física de crianças e adolescentes com deficiência física é menor do que crianças sem deficiência, e isso pode estar relacionado ao seu comprometimento motor. A participação nestas atividades pode ter impacto na qualidade de vida. O objetivo desse estudo foi comparar o nível de atividade física e a qualidade de vida de crianças e adolescentes com deficiência física em relação a idade, sexo e diagnóstico. Participaram 21 crianças e adolescentes com deficiência física, com idade entre 8 e 18 anos, matriculados em escola regular de ensino, e seus responsáveis. Foram utilizados instrumentos padronizados: Physical Activity Questionnaire for Older Children (PAQ-C), Physical Activity Questionnaire for Adolescents (PAQ-A) e KIDSCREEN-52 versão de preenchimento das crianças/adolescentes e versão de preenchimento dos responsáveis. Foram realizados testes não paramétricos para análise estatística. Dados estatisticamente significativos foram encontrados para algumas dimensões da qualidade de vida: 1) quanto ao sexo: “autopercepção” segundo a opinião dos pais/responsáveis; 2) quanto à idade: “autopercepção” no autorrelato, “sentimentos”, “autopercepção”, “amigos e apoio social”, “ambiente escolar” sob o ponto de vista dos pais/responsáveis, e na análise geral da qualidade de vida tanto no autorrelato quanto na versão dos pais/responsáveis; 3) quanto ao diagnóstico: “autopercepção” na versão das crianças/adolescentes e na versão dos pais/responsáveis. Conclui-se que as crianças e adolescentes com deficiência física apresentam baixos níveis de atividade física e níveis médios de percepção de qualidade de vida, sendo que as próprias crianças/adolescentes com deficiência física possuem melhor percepção sobre sua qualidade de vida do que seus pais/responsáveis.
Wie kommt Nachhaltigkeit in Kühlschmierstoffe?
Authors: Joksch Stefan
Published: March 2023

Wer denkt beim Thema Kühlschmierstoff (KSS) schon an Nachhaltigkeit? Wenn überhaupt, kommen den Verantwortlichen in Fertigungsbetrieben technische Parameter in den Sinn. Dennoch hat sich ein KSS-Entwickler und -Hersteller des Themas angenommen.
Perfekt entfettet
Authors: Deininger Sabrina
Published: March 2023

Rund 450 000 Stück Statoren werden jeden Tag an einem Fertigungsstandort in der Nähe von Bern/CH gestanzt. Diese Statoren (innen und außen) werden anschließend in den Montagelinien zu Schrittmotoren zusammengebaut. Für die zuverlässige Funktion müssen die beiden Einzelteile des Schrittmotors perfekt entfettet sein.
Sustainability Assessment
Authors: Ölmez Yalcin
Published: March 2023

Unabhängig von Branche und Geschäftsmodell ist ressourcenschonendes Wirtschaften das Gebot der Stunde. Denn insbesondere für Kunden und Kapitalmärkte ist Nachhaltigkeit heute ein zentrales Thema. Parallel zu dieser Entwicklung entsteht ein klarer werdender und verbindlicher rechtlicher Rahmen.