bluuebunny/crossref_metadata_2025 huggingface dataset:
Prolonged elevation of serum neurofilament light after concussion in male Australian football players
Authors: McDonald Stuart J. , O’Brien William T. , Symons Georgia F. , Chen Zhibin , Bain Jesse , Major Brendan P. , Costello Daniel , Yamakawa Glenn , Sun Mujun , Brady Rhys D. , Mitra Biswadev , Mychasiuk Richelle , O’Brien Terence J. , Shultz Sandy R.
Published: January 2021

Background

Biomarkers that can objectively guide the diagnosis of sports-related concussion, and consequent return-to-play decisions, are urgently needed. In this study, we aimed to determine the temporal profile and diagnostic ability of serum levels of neurofilament light (NfL), ubiquitin carboxy-terminal hydrolase L1 (UCHL1), glial fibrillary acidic protein (GFAP), and tau in concussed male and female Australian footballers.

Methods

Blood was collected from 28 Australian rules footballers (20 males, 8 females) at 2-, 6-, and 13-days after a diagnosed concussion for comparison to their levels at baseline (i.e. pre-season), and with 27 control players (19 males, 8 females) without a diagnosis of concussion. Serum concentrations of protein markers associated with damage to neurons (UCHL1), axons (NfL, tau), and astrocytes (GFAP) were quantified using a Simoa HD-X Analyzer. Biomarker levels for concussed players were compared over time and between sex using generalised linear mixed effect models, and diagnostic performance was assessed using area under the receiver operating characteristic curve (AUROC) analysis.

Results

Serum NfL was increased from baseline in male footballers at 6- and 13-days post-concussion. GFAP and tau were increased in male footballers with concussion at 2- and 13-days respectively. NfL concentrations discriminated between concussed and non-concussed male footballers at all time-points (AUROC: 2d = 0.73, 6d = 0.85, 13d = 0.79), with tau also demonstrating utility at 13d (AUROC = 0.72). No biomarker differences were observed in female footballers after concussion.

Conclusions

Serum NfL may be a useful biomarker for the acute and sub-acute diagnosis of concussion in males, and could inform neurobiological recovery and return-to-play decisions. Future adequately powered studies are still needed to investigate biomarker changes in concussed females.
Evaluating a web- and telephone-based personalised exercise intervention for individuals living with metastatic prostate cancer (ExerciseGuide): protocol for a pilot randomised controlled trial
Authors: Evans Holly E. L. , Forbes Cynthia C. , Galvão Daniel A. , Vandelanotte Corneel , Newton Robert U. , Wittert Gary , Chambers Suzanne , Vincent Andrew D. , Kichenadasse Ganessan , Brook Nicholas , Girard Danielle , Short Camille E.
Published: January 2021

Introduction

Preliminary research has shown the effectiveness of supervised exercise-based interventions in alleviating sequela resulting from metastatic prostate cancer. Despite this, many individuals do not engage in sufficient exercise to gain the benefits. There are many barriers, which limit the uptake of face-to-face exercise in this population including lack of suitable facilities, remoteness, and access to experts, significant fatigue, urinary incontinence and motivation. Technology-enabled interventions offer a distance-based alternative. This protocol describes a pilot two-armed randomised controlled study that will investigate the feasibility and preliminary efficacy of an online exercise and behavioural change tool (ExerciseGuide) amongst individuals with metastatic prostate cancer.

Methods

Sixty-six participants with histologically diagnosed metastatic prostate cancer will be randomised into either the 8-week intervention or a wait-list control. The intervention arm will have access to a tailored website, remote supervision, and tele-coaching sessions to enhance support and adherence. Algorithms will individually prescribe resistance and aerobic exercise based upon factors such as metastasis location, pain, fatigue, confidence and current exercise levels. Behavioural change strategies and education on exercise benefits, safety and lifestyle are also tailored through the website. The primary outcome will be intervention feasibility (safety, usability, acceptability, and adherence). Secondary exploratory outcomes include changes in physical activity, quality of life, sleep, and physical function. Outcomes will be measured at baseline and week 9.

Discussion

The study aims to determine the potential feasibility of an online remotely monitored exercise intervention developed for individuals with metastatic prostate cancer. If feasible, this pilot intervention will inform the design and implementation of further distance-based interventions.

Trial registration

ANZCTR, ACTRN12614001268639. Registered 10 December 2018, https://anzctr.org.au/ACTRN12618001979246.aspx
Dysregulation in growth arrest-specific 5 and metastasis-associated lung adenocarcinoma transcript 1 gene expression predicts diagnosis and renal fibrosis in systemic lupus erythematosus patients
Authors: El-Desoky Manal M. , Shemies Rasha S. , El-Bahnasawy Amany S. , Mostafa Nora , Elhelaly Mona
Published: January 2021

Background

Biomarkers that enhance overall diagnosis and prognosis of systemic lupus erythematosus (SLE) have a growing need to be recognized. The use of long non-coding ribonucleic acids (lncRNAs) as biomarkers in this regard is still largely unexplored. This study aimed to evaluate lncRNA [metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) and growth arrest-specific 5 (GAS5)] expression in SLE patients with/without nephritis. Their relation to disease activity/chronicity changes has been identified. A total of 40 SLE patients and 40 healthy controls were tested using real-time quantitative polymerase chain reaction (PCR) for expression levels of MALAT1 and GAS5.

Results

MALAT1 expression was aberrantly upregulated, while GAS5 was downregulated in patients with SLE versus controls. GAS5 relative expression was significantly downregulated in lupus nephritis (LN) patients compared to non-lupus nephritis (NN) patients. GAS5 was also correlated with glomerulosclerosis, interstitial fibrosis, tubular atrophy, and hypertension.

Conclusion

The lncRNA (GAS5 and MALAT1) may serve as diagnostic biomarkers for SLE. Moreover, GAS5 may distinguish SLE LN patients from NN patients and may predict renal fibrosis in LN patients.
Recombinant Thrombomodulin Attenuates Preeclamptic Symptoms by Inhibiting High-Mobility Group Box 1 in Mice
Authors: Oda Hiroko , Nagamatsu Takeshi , Schust Danny J , Cabral Horacio , Miyazaki Takuya , Iriyama Takayuki , Kawana Kei , Osuga Yutaka , Fujii Tomoyuki
Published: January 2021

Preeclampsia (PE) is a common gestational complication that involves systemic endothelial dysfunction and inflammatory responses primarily due to placental damage. Recombinant thrombomodulin (rTM), a novel anticoagulant clinically used for disseminated intravascular coagulation, is reported to have a unique anti-inflammatory endothelial repair function by inhibiting proinflammatory mediator high-mobility group box 1 (HMGB1).

Despite the severe patient outcomes, there are currently no effective therapeutic options to treat PE. Here, we verified the efficacy of rTM as a novel therapeutic agent for PE using a murine model and human trophoblast cells.

We revealed the therapeutic potential of rTM in an angiotensin II(Ang II)-induced PE mouse model. Injection of rTM significantly attenuated clinical features of PE, such as hypertension, proteinuria, fetal growth restriction, and impaired placental vasculature. Elevation of maternal soluble fms-like tyrosine kinase-1 (sFlt-1), a well-accepted causal factor of PE that induces systemic endothelial dysfunction, was suppressed in response to rTM treatment. Supporting these findings, our in vitro experiments revealed that rTM reduces Ang II-triggered overproduction of sFlt-1 in human trophoblast cells. Moreover, interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α), well-known key inflammatory mediators in PE pathogenesis, were diminished by rTM. SiRNA knockdown experiments further determined that these processes were directly mediated by HMGB1.

Our studies demonstrate that rTM exerts its clinical effect as HMBG1 inhibitor and ameliorates placental dysfunction, which is central to PE pathogenesis. Our findings suggest that rTM could be a promising therapeutic that significantly improve the outcomes of PE patients.
Polybrominated Diphenyl Ethers in Human Follicular Fluid Dysregulate Mural and Cumulus Granulosa Cell Gene Expression
Authors: Lefèvre Pavine L C , Nardelli Thomas C , Son Weon-Young , Sadler Amy R , Rawn Dorothea F K , Goodyer Cindy , Robaire Bernard , Hales Barbara F
Published: January 2021

Polybrominated diphenyl ethers (PBDEs), a major class of flame retardants incorporated into numerous consumer products, leach out into dust resulting in widespread exposure. There is evidence from in vitro and in vivo animal studies that PBDEs affect ovarian granulosa cell function and follicular development, yet human studies of their association with female infertility are inconclusive. Here, we tested the hypothesis that exposure to the PBDEs in follicular fluid is associated with dysregulation of gene expression in the mural and cumulus granulosa cells collected from women undergoing in vitro fertilization by intracytoplasmic sperm injection. The median concentration of the ∑ 10PBDEs detected in the follicular fluid samples (n = 37) was 15.04 pg/g wet weight. RNA microarray analyses revealed that many genes were differentially expressed in mural and cumulus granulosa cells. Highest vs lowest quartile exposure to the Σ 10PBDEs or to 2 predominant PBDE congeners, BDE-47 or BDE-153, was associated with significant effects on gene expression in both cell types. Mural granulosa cells were generally more sensitive to PBDE exposure compared to cumulus cells. Overall, gene expression changes associated with BDE-47 exposure were similar to those for ∑ 10PBDEs but distinct from those associated with BDE-153 exposure. Interestingly, exposure to BDE-47 and ∑ 10PBDEs activated the expression of genes in pathways that are important in innate immunity and inflammation. To the best of our knowledge, this is the first demonstration that exposure to these environmental chemicals is associated with the dysregulation of pathways that play an essential role in ovulation.
Διερεύνηση της ακαδημαϊκής υποεπίδοσης σε μαθητές υψηλών γνωστικών και μαθησιακών ικανοτήτων με βάση το Μοντέλο Προσανατολισμού στην Επίδοση
Authors: Μπελογιάννη Βασιλική , Ζμπάινος Δημήτριος
Published: January 2021

Η μη αναμενόμενη χαμηλή σχολική επίδοση ή «υποεπίδοση» αποτελεί ένα ιδιαίτερα συχνό και σύνθετο φαινόμενο που απαντά σε μαθητές απ’ όλο το εύρος των γνωστικών και μαθησιακών ικανοτήτων και ιδιαίτερα στους μαθητές με υψηλές ικανότητες. Παρά τη συχνότητά της, ωστόσο, η υποεπίδοση αποτελεί ζήτημα που έχει απασχολήσει ελάχιστα την ελληνική εκπαιδευτική έρευνα. Η ανεπαρκής μελέτη του φαινομένου και των παραγόντων που συνδέονται με την εμφάνισή του, καθώς και η απουσία μεθόδων εντοπισμού μαθητών υψηλών ικανοτήτων με υποεπίδοση συνεπάγεται την απουσία στοχευμένων κι αποτελεσματικών μεθόδων για την αντιμετώπισή του. Λαμβάνοντας υπόψη τα παραπάνω, η παρούσα εργασία αποβλέπει στον εντοπισμό μαθητών υψηλών γνωστικών και μαθησιακών ικανοτήτων με υποεπίδοση και τη διερεύνηση της σχέσης της με μια σειρά παραγόντων, όπως τα κίνητρα, η αυτορρύθμιση, οι στάσεις απέναντι στο σχολείο και τους εκπαιδευτικούς, με βάση το Μοντέλο Προσανατολισμού στην Επίδοση. Προς το σκοπό αυτό στην παρούσα έρευνα συμμετείχαν 519 μαθητές Γυμνασίου από 7 δημόσια σχολεία της Αθήνας με μέση ηλικία τα 13,7 έτη. Για τον εντοπισμό των μαθητών υψηλών ικανοτήτων κι εκείνων που παρουσίαζαν υποεπίδοση χρησιμοποιήθηκαν οι Προοδευτικές Μήτρες του Raven και το Κριτήριο Μαθησιακής Επάρκειας Detroit, καθώς και οι καρτέλες της σχολικής βαθμολογίας τους. Από την ανάλυση εντοπίστηκαν συνολικά 76 μαθητές με υποεπίδοση εκ των οποίων 15 παρουσίαζαν υψηλές γνωστικές και μαθησιακές ικανότητες, ενώ 61 προέρχονταν από το υπόλοιπο εύρος των γνωστικών και μαθησιακών ικανοτήτων. Περαιτέρω αναλύσεις του ρόλου των στάσεων απέναντι στο σχολείο, όπως προέκυψαν από τη χορήγηση του Ερωτηματολογίου Νοοτροπιών απέναντι στο Σχολείο, κατέδειξαν ότι οι μαθητές με υποεπίδοση παρουσίαζαν στατιστικά σημαντικές διαφορές από τους συμμαθητές τους στα κίνητρα και την αυτορρύθμιση. Επιπλέον, οι μαθητές με χαμηλή αποτίμηση των ακαδημαϊκών στόχων, φτωχά κίνητρα και ελλιπή αυτορρύθμιση έτειναν να παρουσιάζουν σοβαρότερη υποεπίδοση από τους συμμαθητές τους. Τα παραπάνω ευρήματα μπορούν να συμβάλουν στην κατεύθυνση της καλύτερης κατανόησης της υποεπίδοσης, αλλά και του σχεδιασμού παρεμβάσεων για την ψυχοπαιδαγωγική αποκατάστασή της.
Design of Measurement of Coffee Seed Water Content Using Load Cell Sensor On Coffee Dryer
Authors: Mistu Adi Putra Muhammad , Herlina Amalia
Published: January 2021

The conventional method of drying coffee beans that depend on sunlight (drying) has a number of drawbacks, one of which is that the drying productivity takes a long time. In general, coffee drying is carried out until it reaches a moisture content of 12.5% to achieve a quality bean standard. Mathematically, the moisture content can be assessed by paying attention to the initial weight of the coffee beans and the final weight of the coffee beans. So that the use of the Load Cell sensor to read the depreciation value of the coffee bean weight on a coffee dryer powered by Hybrid Collector and LPG coffee beans. Research that has been carried out during 200 minutes of drying in a coffee dryer, the Load Cell sensor is able to read the depreciation value of the coffee bean weight by 114 grams from the initial weight of 978 grams. Therefore, it can be concluded that the final moisture content of coffee beans has reached 12.01% and the final weight of coffee beans is 864 grams.
Design of Water Level Control in Tank Based on Fuzzy Logic
Authors: Imaduddin Ilmi Rizki
Published: January 2021

Liquid level control is a regulatory system that is widely used by the petrochemical industry, paper mills, and steam power plants (PLTU). Fuzzy control techniques have light computing capabilities and do not require knowledge of the parameters of the system. The purpose of this research is to design and design a device that can make it easier to adjust the liquid level in the storage tank and observe the fuzzy control performance. Control is done by adjusting the valve opening in the storage tank. From the results of this study, data on setpoint 56 is obtained, the valve is at an angle with all open status (BS), at the first second or 1 second, and at set point 41, the valve is at an angle with a half-closed status (SN), in the 13th second, and the valve will be closed all (NS), if the valve is at an angle at the set point 29, with a time of 1620 seconds or 27 minutes. Based on this research, the proposed system is able to control the water level in the tank using fuzzy control.
Some additional notes on the spectra of non-negative symmetric 5 x 5 matrices
Authors: Loewy Raphael
Published: January 2021

The Symmetric Non-negative Inverse Eigenvalue Problem (SNIEP) asks when is a list $ \sigma = \left( \lambda_{1}, \lambda_{2}, \dots, \lambda_{n} \right) $ of real, monotonically decreasing numbers, the spectrum of an $n \times n$, symmetric, non-negative matrix $A$. In that case, we say $\sigma$ is realizable and $A$ is a realizing matrix. Here, we consider the case $n=5$, the lowest value of $n$ for which the problem is unsolved. Let $ s_{1}(\sigma) = \sum_{i=1}^5 \lambda_{i} $ and $ s_{3}(\sigma) = \sum_{i=1}^5 {\lambda_{i}}^3 $. It is known that to complete the solution for $n=5$, it remains to consider the case $\lambda_{3} > s_{1}(\sigma)$, so let $y=\lambda_{3}- s_{1}(\sigma)$ and assume $y \geq 0$. We prove that if $\sigma$ is realizable, then $s_{3}(\sigma) \geq s_{1}(\sigma)^3+6s_{1}(\sigma)y(s_{1}(\sigma)+y)$. This strengthens the inequality $s_{3}(\sigma) \geq s_{1}(\sigma)^3$ obtained by Loewy and Spector, which in turn strengthens the inequality $ 25s_{3}(\sigma) \geq s_{1}(\sigma)^3 $, one of the Johnson--Loewy--London inequalities. As an application of the new inequality, we show that certain lists previously unknown as far as their realizability is concerned are not realizable.
Structural Changes of Circularly Defected Monolayer Circular Graphene Nanosheets Upon Mechanical Vibrations
Authors: Farzannasab M. , Khatibi M. M. , Sadeghzadeh S.
Published: January 2021

As the strongest and toughest material known, graphene has found numerous applications in various types of sensors. Due to the great influences of the graphene sheet’s geometry on resonance frequency, circular defects could effect on expected results of sensors. Circular holes in circular graphene sheets (CGSs) have been modeled with molecular dynamics (MD) simulation in the present work. Then the vibration behavior of intact circular plate and circular sheet with the circular defect has been investigated using frequency-domain analysis (FDD). Furthermore, for validating the used method, the obtained natural frequencies for different graphene sheets have been compared with acquired data in former research. The result of validation showed the accuracy of the used method in this study. The results indicated that by increasing the hole size, the natural frequency of a defected sheet with free edges will be diminished, and with simply-supported interior boundary conditions typically went up. Also, by increasing the hole’s eccentricity, the natural frequency of the defected graphene sheet will be diminished when the hole boundary was subjected to simply-support or free condition.
Buckling and Wrinkling of a Thin Solid Film with Non-uniform Thickness
Authors: Noroozi Masoud
Published: January 2021

The instability of a strip as a free-standing film and also a deposited film on a substrate is studied in this work. The non-uniform thickness of the film is assumed with a quadratic profile. The problem is categorized under the topic of structural stability and the eigenvalue problem corresponding with the ODE of the system is solved. For the free-standing film, the buckling loads and mode shapes are derived analytically through a closed-form solution. For the substrate-bonded film with a finite length, the uniaxial wrinkling of the film is investigated by using a series solution and a finite difference method and the wrinkling load and wrinkling pattern are characterized. Unlike the wrinkling of thin films with uniform thickness in which the wrinkles propagate along the entire span, it is shown that for the non-uniform film wrinkles are localized near the location with a minimum thickness along the length span; and the wrinkling accumulation is very sensitive to the thickness variations. Therefore, this work is expected to increase the insight into the localization of the wrinkles in thin film-substrate systems in engineering, industry and medical science.
FORM-MAKING METHODS IN LANDFORM ARCHITECTURE
Authors:   Department of buildings, structures and design of the architectural environment, Kuznietsova Yana ,   Faculty of Architecture, Design and Fine Arts,   O.M. Beketov National University of Urban Economy in Kharkiv, Osychenko Halyna ,   Department of buildings, structures and design of the architectural environment; Faculty of Architecture, Design and Fine Arts; O.M. Beketov National University of Urban Economy in Kharkiv
Published: January 2021

In this study, we consider a critical challenge in architectural design methodology-methods of form making in landform architecture. Based on the authors’ methodology, the approaches and methods of form making are specified and systematized, depending on the algorithm of the form-making process and the basic principles of building composition. The approaches to architectural form making, including image-based, generative, and functional approaches are determined. The methods within the framework of the image-based approach are identified. These methods include natural «mimicry» and metaphorical methods, as well asan image-based and combinatorial method. Furthermore, the principles and techniques of form-making methods are examined, and their capability and potential to create esthetically expressive and poetically shaped buildings, which can be integrated into existing natural landscapes, are determined.
NUMERICAL INVESTIGATIONS OF FLUSHING TIME IN SMALL MARINAS
Authors:   Zagreb University of Applied Sciences, Department of Civil Engineering, Bartolić Ivana , Lončar Goran ,   Faculty of Civil Engineering, University of Zagreb, Bujak Damjan ,   Faculty of Civil Engineering, University of Zagreb, Carević Dalibor ,   Faculty of Civil Engineering, University of Zagreb
Published: January 2021

This paper presents the results of 2D and 3D numerical simulations of sea circulation and water mass exchange for a marina with hypothetical dimensions (L/B=2 and L/B=0.5) to calculate the return flow factor. The return flow factor b was analyzed in relation to the marina entrance width, sea current velocity outside the marina (0, 1, 2, and 5 cm/s) and the sea surface level oscillation dynamics. The basic comparative parameter is the e-flushing time, Tf. The intensity of forced circulation is calculated to achieve time Tf of less than 10 days. The impact of the wind field on the e-flushing time for different marina widths was analyzed using a 3D numerical model. The numerical simulation results indicate that the e-flushing time Tf depends on the amplitude of the tidal signal, secondary to the width of the marina inlet, and the smallest amount on the velocity field in the outer region. Conversely, the return flow factor b depends on the width of the marina entrance, less on the tidal signal amplitude, and least on the current velocity outside the marina if currents are ≥ 1 cm/s. Forced circulation of 1 m3/s is only required for the marina with a smaller tidal amplitude (position Dubrovnik) to achieve Tf<10 days. If at the observed location wind is a dominant sea circulation generator, a wider marina entrance will allow faster sea exchange.
RFID adatbiztonság
Authors: Csikós Sándor , Sárosi József , Czifra György
Published: January 2021

A „rádiófrekvenciás azonosítás” (RFID) technológiákat már a II. világháború óta alkalmazzák. A technológia lényege, hogy legalább az egyik felet azonosítsa. A negyedik ipari forradalomban ez a technológia talán a legjobb jelölt az okos termékek megvalósítására. Ez az új használati kör új biztonsági feladatokat jelent, amik megoldásra várnak. Ilyenek például az adat biztonság és adat integritás biztosítása. Ebben a cikkben az RFID technológiákon ismert támadások és a lehetséges védelmi módszerek kerülnek bemutatásra.
The Formation of Communicative and Speech Competence in Teaching Russian as a Foreign Language (from the Experience of Teaching Russian to Chinese Students)
Authors:   Алтайский государственный университет (Барнаул), Беликов Сергей Владимирович , Качесова Ирина Юрьевна
Published: January 2021

В статье рассматривается коммуникативно-речевая компетентность как база преподавания русского языка как иностранного китайским студентам. Понятие коммуникативной компетентности связывается с формированием коммуникативной парадигмы РКИ. В статье в качестве базовых условий, определяющих коммуникативный подход к преподаванию русского языка как иностранного, выделяются дискурсивность и риторичность. Дискурсивные характеристики связываются с особыми этнопризнаками китайской культуры: влияние конфуцианской идеологии, целостность видения мира, специфический двигательно-зрительный тип памяти. Риторические характеристики определяются базовыми категориями риторической парадигмы. В качестве частного случая описывается речевая интенция.
Homo heroicus in Old English Literature: Linguistic and Axiological Approach
Authors:   Уральский федеральный университет (Екатеринбург), Томберг Ольга Витальевна
Published: January 2021

В статье раскрывается специфика основных героических образов древнеанглийской литературы как художественной проекции темы героизма, которая являлась мировоззренческой доминантой периода VI–XI вв. н.э. Особенности репрезентации образов рассматриваются в зависимости от их жанровой природы. В статье применяется лингвоаксиологический подход к анализу героической личности. На стилистическом уровне речь идет о сюжетных функциях и лингвостилистических маркерах образов, на коммуникативном – поведенческих паттернах, на концептуальном – связи образов с аксиологемами древнеанглийской культуры. Образы героя и воина имеют истоки в архаичной мифопоэтической культуре, что репрезентировано на уровне их ономастикона. Различия в ценностном содержании этих образов обусловлены бо́льшим жанровым охватом образа воина, что приводит к раскрытию внутреннего мира героической личности. Доминантным чувством героической личности древнеанглийской литературы является чувство горя. Король героической эпохи интерпретируется как мудрый немолодой правитель, его образ проникнут христианским миросозерцанием.
Artistic and Intentional Signs of Confessions and Sermons in V.P. Astafyev's Story "Drop" from the book "Queen Fish"
Authors:   Красноярский государственный педагогический университет им. В.П. Астафьева, Сазанов Владимир Владимирович
Published: January 2021

Статья посвящена исследованию особенностей авторской интенции в рассказе В.П. Астафьева «Капля» из книги «Царь-рыба». Содержание произведения рассматривалось исследователями в аспекте социально-нравственных проблем современности, важнейшей из которых в 1970-е годы становится экологическая. В традиционное реалистическое повествование Астафьев включает лирико-философский компонент, имеющий черты религиозных жанров – проповеди, исповеди. При всей неоднозначности научных суждений о религиозном поиске писателя очевидна возможность выявления в рассказе «Капля» жанрово-художественных признаков, свидетельствующих о вполне определенных психологических, религиозно-философских установках автора, что составляет актуальность и новизну предлагаемого исследования. Мотив благодарности и радостного приятия жизни является одним из доминирующих в христианском мироощущении, а в данном тексте является доказательством философско-религиозной авторской идеи. Элементы исповедально-проповеднического нарратива проявляются как «память жанра», как направленность творческого сознания Астафьева на постижение законов существования жизни.
Metaphorical Models Verbalized in the English Professional Advertising Discourse: Anthropomorphic Metaphorical Model
Authors:   Пятигорский государственный университет, Цолоева Седа Батыровна
Published: January 2021

Статья посвящена изучению англоязычного профессионального рекламного дискурса с акцентом на употребление в нем антропоморфной метафорической модели Designer Product is Living Being, основанной на ассоциативной связи двух элементов и распадающейся далее на более частные метафорические трансформации. Материалом исследования служат англоязычные рекламные тексты, опубликованные в журнале The Art of Design, тематически относящиеся к области дизайна и архитектуры. По мнению автора, в структуре метафоры наличествуют метафорическое ядро и метафорическая периферия, актуализирующие основную и дополнительную смысловую метафорическую нагрузку соответственно. Опираясь на результаты эмпирического анализа языкового материала, автор выделяет антропоморфную метафорическую модель Designer Product is Living Being, реализующую на семантическом уровне перенос, сводящийся к тому, что тот или иной дизайнерский продукт наделяется характеристиками, качествами, присущими, как правило, человеку. В работе представлены статистические данные, определяющие частотность применения антропоморфной метафоры в пределах анализируемой выборки англоязычных рекламных текстов.
Updated checklist of the Umbelliferae of Middle Asia and Kazakhstan: nomenclature, synonymy, typification, distribution
Authors: Pimenov Michail G.
Published: January 2021

The region of Middle Asia and Kazakhstan with 107 genera, 459 species and 204 endemic species is one of essential Umbelliferae diversity centers not only in Asia, but also in the world. The biggest Umbelliferae genera in the region are Ferula (100 species), Seseli (49), Elwendia (19), Bupleurum (18), Elaeosticta (18), Prangos (16), Semenovia (16). The diversity of the family by country is as follows: Kazakhstan (82 genera – 211 species – 28 endemic species), Uzbekistan (68 – 200 – 18, respectively), Kyrgyzstan (65 – 192 – 29), Tajikistan (65 – 176 – 20), and Turkmenistan (51 – 122 – 9). The latter differs considerably from other countries of the region not only in lesser diversity, but also in generic and specific sets, approaching the features of Iranian Umbelliferae. The distribution of species was described with regard to provinces of all five countries. The list of endemic species for each country was compiled on the basis of field, herbarium and published data. There are 16 endemic genera in Middle Asia and Kazakhstan, including Astomatopsis, Autumnalia, Fergania, Kafirnigania, Karatavia, Komarovia, Kuramosciadium, Lipskya, Mogoltavia, Paulita, Pilopleura, Schtschurowskia, Sclerotiaria, Sphaenolobium, Sphaerosciadium, and Tschulaktavia, 6 other genera being subendemics. Across the region the important border between Middle Asian (eastern part of SW Asian floristic province of the Mediterranean type) and Central Asian phytochoria passes; the former being considerably richer in the Umbelliferae than the latter.
STUDY OF THE PROPERTIES A FRAGMENT OF THE HYDRAULIC CIRCUIT OF THE SPACECRAFT, OBTAINED BY MEANS OF ADDITIVE TECHNOLOGIES
Authors: Mal’tzev I. E. , Basov A. A. , Borisov M. A. , Bystrov A. V.
Published: January 2021

The article discusses the course and results of experimental work on the initial study of the possibility of using one of the varieties of additive technologies – the method of layer-by-layer selective laser melting (SLM) in the manufacture of elements of heat exchangers and hydraulic circuits of spacecraft. Traditional manufacturing techniques for hydro-control elements and spacecraft heat exchangers are based on machining and high-temperature vacuum soldering, leading to a long cycle and high manufacturing costs. As an alternative, the method of layer-by-layer selective laser melting can be considered as a manufacturing method using a three-dimensional model of the product and not requiring additional equipment. This method is based on sequential layer-by-layer fusion of a metal powder with previous fused product layers under the action of a laser beam forming a local region of liquid melt. The article describes experimental work to assess the possibility of using the selective laser melting method. Assessed weld-ability of a sample made by selective laser fusion technology with tips made by traditional technology. Directions for testing the method of selective laser sintering on real structures of heat exchanging units of spacecraft have been determined. A technique is proposed and the results of a study of a sample synthesized by selective laser sintering are presented. Based on the results obtained, an analysis is made of the prospects for using this method in the production of elements of hydraulic circuits and heat exchange units of spacecraft.
DETERMINATION OF THE QUALITY LEVEL OF THE TECHNOLOGICAL PROCESS AT THE STAGE OF DEBUGGING
Authors: Sepeseva Yu. A. , Bavykin O. B. , Petukhov I. S.
Published: January 2021

An algorithm for determining the quality level of gas forming technology in the superplasticity mode of the material at the debugging stage is Developed. Proposed management measures to improve the new technology, which can help reduce the percentage of defects in the production of parts.
CONTROLLING THE PROPERTIES OF THE SURFACE LAYERS OF PARTS BY COMBINED PROCESSING
Authors: Yakovleva A. P. , Savelyeva L. V.
Published: January 2021

The paper focuses on a combined processing method developed to control the properties of the surface layer of parts. A regular micro-relief was obtained on the surface, with oil pockets to hold the lubricant during the friction process. Profilograms of samples processed by different modes and a model of the process of obtaining regular micro-relief are presented. We carried out comparative endurance tests of the samples processed by various methods. For the study the samples of steel SA-240 TP 310S were selected. The results obtained allow us to recommend combined processing for the parts operating under conditions of intense friction with lubrication.
DEVELOPMENT OF A METHOD OF HYDROEROSIVE SATURATION OF LIQUIDS WITH MICROPARTICLES OF TARGET MATERIALS USING ULTRAJET
Authors: Galinovisky A. L. , Erokhin S. A. , Chzheniuan Tszia
Published: January 2021

The article is deal with the questions of assessing the applicability of the method of ultra-jet diagnostics of carbon plastics. In the work, phenomenological ideas about the process of destruction of carbon plastics under the action of a high-speed-jet of liquid are considered. The experimental part of the work is related to the implementation of the diagnostic effect of the ultra-jet on the surface of the carbon fiber reinforced plastic, the assessment of the geometric parameters of the hydraulic caverns and the qualitative assessment of the state of the fibers and the adhesion in the binder-fiber structure. In this experiment, carbon fiber samples were used both in the initial state and after the inhibitory effect of x-ray radiation. Such a technique made it possible to carry out a comparative analysis of the samples and evaluate the information content of the ultra-jet diagnostics method as applied to the materials under consideration.
KINEMATIC AND DYNAMIC ANALYSIS OF A LINEAR DELTA ROBOT
Authors: Saprykina N. A. , Proskokov A. V. , Saprykin A. A.
Published: January 2021

Mechanisms with parallel kinematics are the subject of many theoretical and applied research problems. The article proposes a design of a linear 3D printer with Delta kinematics. A structural analysis of the mechanism is carried out, and a method for determining kinematic and dynamic characteristics that affect the spatial synthesis of parallel robots is given. This work will help engineers or researchers to choose the geometric parameters of the printer to perform the required tasks.
SOME FEATURES AND FORMALIZED RELATIONS IN THE MIXED DESIGN OF TECHNOLOGICAL PROCESSES FOR THE MANUFACTURE OF MACHINE PARTS
Authors: Kondakov A. I.
Published: January 2021

Modern CAPP systems do not fully meet the needs of machine part production. The main reason for this is the use methodological approaches characteristic of non-automated design in them. In particular there is the division of technological design into route and operational parts. This article proposes a proven methodology for determining the composition of technological operations, which are successively formed by the concentration of technological transitions in a single mixed technological process. It is shown that the most important procedures of this approach are the assessment of openness for processing the workpiece zones for a given installation scheme, and verification of compliance with the required dimensional relations between the elements of these zones. The implementation of this approach opens up new prospects in the creation of highly efficient CAPP systems.
ESTIMATION OF PARAMETERS OF STRENGTH AND RELIABILITY OF A SECTION OF A STEEL GAS PIPELINE TAKING INTO ACCOUNT VERTICAL SECTIONS ON THE NOVODEVICHY DUKER PROJECT WITH APPLICATION OF NUMERICAL METHODS
Authors: Murzakhanov G. Kh. , Barsukov A. A. , Semenov A. S. , Makshin A. V.
Published: January 2021

Article considered main stages of strength calculation of the steel gas pipeline under the Novodevichy Duker project. Specialists of the Moscow city Center used the basis of the finite element for calculation. The list of tasks consists of: 1. Strength calculation of the underground laying gas pipeline section. 2. The calculation of the stability of the two vertical sections. According to the results of strength calculation, specialists made the conclusion about ensuring the strength and stability of the considered section of the gas pipeline.
STUDY OF OPTICS FOR LED LIGHT DEVICES AND METHODS OF ITS COMPUTER MODELING
Authors: Bayneva I. I. , Komarov N. S.
Published: January 2021

The article discusses optical systems for LED lighting devices, the principles of the propagation of rays in lenses of various designs. Analyzed the features of the secondary use of the optical elements in the form of lenses and prisms for different LED emission patterns in space. Considered the features and problems of calculation of the secondary optical systems. Problems and prospects of application are considered, research and computer modeling of optics, which is used to form the required light distribution in LED light devices. Computer modeling technologies and the mathematical methods that underlie them determine the possibility of developing such optical systems in lighting installations. The article considers the numerical Monte Carlo simulation method, which allows one to organize ray tracing modeling in optical systems. The TracePro software package for modeling and research of lighting devices and their optical elements allows you to automate the stage of their calculation and design, this significantly reduces the cost of developing new products. The prototyping of three-dimensional models of lens systems opens up great opportunities for manufacturers of optics for LEDs, allows research on prototypes planned for production of serial products.
DEVELOPMENT OF A CENTRIFUGATION-BASED PLANT DESIGN TO IMPROVE THE TECHNICAL AND ECONOMIC INDICATORS OF FRITS
Authors: Soshina T. O. , Vozakov A. M. , Pikuleva A. S. , Sokolov D. A.
Published: January 2021

The technical solution aimed at reducing the energy loss of the enterprise during drying of the frit is considered: the exclusion of the electric heaters and fan, the use of centrifugation for the developed design of the installation. Analysis of the static and dynamic characteristics of the installation was performed in APM FEM with a uniform load distribution along the bottom of the rotor. The functional problem of smooth starting and braking of the centrifuge drum was solved using an adjustable electric drive with a frequency converter, which provides step control up to 5 rpm. The annual economic effect of the implementation of the installation for drying frits is calculated.
PROBLEMS AND PROSPECTS OF LED LAMP RETROPHYTES
Authors: Bayneva I. I. , Lychagin I. A.
Published: January 2021

The article discusses modern light sources – LED retrofit lamps, which are used to replace traditional light sources (incandescent, fluorescent lamps). The article provides calculated data showing energy savings as a result of replacing traditional light sources with LED ones. LEDs have undeniable advantages over such light sources. This is a high luminous efficiency, durability, color reproduction and much more. Ample opportunities for direct replacement of LED lamps are associated with their form factor, which is the same as that of traditional light sources. The main parameters of the form factor in this case are the sizes of the light sources (bulb diameter) and the type of cap. However, direct replacement has many controversial sides. Firstly, the light environment created by traditional incandescent lamps is very different from that for LED light sources due to the difference in their spectral light distribution. Secondly, the light intensity curves of LED and traditional light sources are very different in a number of cases. Therefore, direct replacement must be carried out very carefully, taking into account the final light distribution of the light device, where they are used. Thirdly, due to the incompleteness of research in the field of safety of LED lighting, the use of such light sources can be limited due to the potential hazard that may lead to a decrease in labor productivity and quality of life. Fourth, the design of LED lamps is complex, their quality depends on the quality of LEDs, phosphors and electronics, so consumer properties may not be at the highest level, even at fairly high prices. Fifthly, for any, even the simplest LED lamp, a heat sink system is necessary, since the thermal regime of the lamps imposes certain restrictions on their use.
METHOD FOR CALCULATING THE RELIABILITY OF QUARTZ RESONATORS
Authors: Boychuk M. I. , Vasileva L. A. , Mikaeva S. A.
Published: January 2021

In the process of developing a thermocompensated quartz generator, it was necessary to calculate the reliability indicators of such an important element of the circuit as a quartz resonator for a failure-free period of 15 000 hours. The main parameter that can be used to evaluate the reliability of the quartz resonator is the stability of the nominal oscillation frequency. It is the stability of the nominal frequency of the resonator that formed the basis of the new developed technique. The method includes rules for constructing a probabilistic and statistical model of the dependence of the resonator frequency change on the test time. The article describes the work done on the accelerated evaluation of the reliability of piezoelectric resonators RK563 on the basis of probabilistic and statistical modeling of the behavior of the frequency from the test time. The method of mathematical modeling is based on the results of incomplete tests for a period of 30…50 % of the set value of the minimum operating time.
FORMALIZATION OF MARGIN OF ERROR CALCULATION LOCATION IN V-BLOCK SHAFT TYPE BLANKS
Authors: Savelieva L. V. , Moskvin M. B. , Tsuishan Li , Pi Yao
Published: January 2021

In this article the dependence of highness’s margin of error of part’s axe position when this part of cylindrical shape is located in V-block was determined. As a result, the bunch graphs for defining this type of margin of error for parts’ diameters from 25 to 250 mm were obtained.
EXPERIMENTAL STUDY OF THE COMPRESSIBILITY OF FLANGES WITH A SLIGHTLY RIGID GASKET INSTALLED BETWEEN THEM
Authors: Buketkin B. V. , Zyablikov V. M. , Semenov-Ezhov I. E. , Shirshov A. A.
Published: January 2021

In many cases, the threaded connections of the parts (together with the gaskets) must provide the tightness necessary for the machine to work. This is possible if, after loading the joint with a Central force or bending moment, contact pressure is guaranteed over the entire contact surface of the parts. The threaded connection model, which consists of two disks with a flat gasket made of a low – hardness material, paronite, placed between them, was subjected to compression, simulating the tightening force, on a test machine. A special device was used to determine the total deformation of disks along radii from the center to the periphery in order to experimentally determine the length of the disk contact zone. It was found that with increasing stiffness of the joint parts, the contact pressure gradient decreases, and the area of its propagation increases.
COMPARATIVE ANALYSIS OF THE RESULTS OF THE HOMOGENIZATION OF NANOSUSPENSIONS BY THE METHOD OF ULTRA-JET TREATMENT
Authors: Htet K. M. , Galinovskiy A. L. , Barzov A. A. , Avtushenko A. A.
Published: January 2021

The article considers the urgent problem of finding new highly effective methods for dispersing suspensions prepared using nanomaterials (boehmite, graphene, nanotubes). Based on comparative experimental data, it is shown that the ultra-jet treatment method has several advantages. For experiments, standard equipment for waterjet cutting of materials was used. A single crystal of diamond was used as a target for a high-speed nanosized suspension, the fastening of which was carried out in special technological equipment, which also performs the functions of collecting the treated liquid. The experimental results showed that the particle size after ultra-jet treatment exceeds the result of the traditional method of homogenization – ultrasonic treatment. An important result of the research was the establishment of the fact that the homogenization process begins at the stages of the passage of the nanosuspension through the focusing tube, and not only in the process of collision of the ultrajet liquid with the barrier.
CONTROL OF PIEZOELECTRIC PRODUCTS JUNCTION
Authors: Vasilyeva L. A. , Boychuk M. I. , Mikaeva S. A.
Published: January 2021

The article describes the work on the use of capillary fluorescent flaw detection for the control of metal-glass junction of piezoelectric products. Within the framework of the work, standard methods of testing piezoelectric products for tightness were analyzed, their analysis was carried out, and the scope of applicability of each of them at the stages of the life cycle of piezoelectric products was established. In the course of work, capillary control methods were considered for use in production and their advantages were highlighted. As a result of the work carried out, a capillary luminescent control method was chosen to check the tightness of piezoelectric products in the area of the metal-glass junction. The stages of the capillary luminescent control method are described. Based on the conducted research, a method for controlling the tightness of piezoelectric products was developed, including the use of a capillary luminescent method.
STUDY OF EFFICIENCY OF DRUM DRYERS OF METALLURGICAL PRODUCTIONS USING PERFORATED PIPES WITH LOCALIZATION OF HEAT FLOWS
Authors: Kokorin V. N. , Yemeniev P. V. , Duyun O. G. , Krupennikov O. G.
Published: January 2021

The article presents the design of a drum furnace, providing for the provision of differentiated heat flows through the use of an internal perforated pipe. The design of the presented horizontal drum dryer with a perforated tube having openings is designed to eliminate such technological risk factors as the ignition of the oil component of the processed material, and the metal dispersed material itself having pyrophoric properties. As a result of the numerical simulation using the LS–DYNA program, the temperature and heat fluxes in the quasi-boiling zone of the drained oil-containing dispersed material were determined. The calculations made it possible to establish the dependence of the temperature in the quasi-boiling zone on the number of holes of the perforated pipe. Analysis of the obtained graphs allows us to conclude that the gradient of temperature (heat) flows in fixed sections of the furnace of the quasi-boiling zone.
AIRCRAFT STRENGTH ASSEMBLIES AND PARTS (BALANCERS) DRAWINGS DEVELOPMENT METHODOLOGY
Authors: Anamova R. R. , Leonova S. A. , Khvesyuk T. M.
Published: January 2021

It is obvious that the fundamental knowledge of the general technical discipline “Engineering graphics” should be in combination with a practical course of computer graphics, which allows students to integrate into the aviation products development system at the contemporary level. The article highlighted the need of design teaching at the initial stage of engineering and computer graphics study process. A drawing methodology includes 3D-modeling in a computer aided design program named COMPAS-3D. It is described a specific example of the mechanical part (aviation detail's elements – balancers) with complex shape modeling algorithm in the application to the manufacturing technology of real products (casting, stamping, mechanical processing). Drawings development is based on 3D-modeling in COMPAS-3D. Proposed methodology was tested during engineering and computer graphics lessons in Moscow Aviation Institute (National Research University).