bluuebunny/crossref_metadata_2025 huggingface dataset:
Physical effort – an underused preventable method in colorectal cancer
Authors: Pătrășescu Mihăiță , Nuță Petruț , Costache Raluca S. , Bucurică Săndica , Macadon Bogdan , Balaban Vasile , Popescu Andrada , Calin Roxana , Raduta Ioana , Pantile Daniel
Published: April 2022

Abstract: Colorectal cancer prevalence is increasing worldwide. Modifiable risk factors are responsible for almost 50 % of cases and this could imply a huge potential of preventability. Among these factors the level of physical activity is of paramount importance. Physical activity has a positive impact on health status in general and it decreases the prevalence of various cancers including colorectal cancer. Physical activity decreases the prevalence of benign colorectal adenomas and it prolongs the disease free interval after surgery in colorectal cancer, thus increasing survival. The mechanisms involved are multiple: decreasing bowel transit time, regulating energy balance, decreasing peripheral insulin resistance, decreasing hyperinsulinism, antiinflamatory effects, increasing vitamin D production.
Atypical Cogan syndrome; case report
Authors:   St Maria General Hospital, Bucharest, Romania  Carol Davila University of Medicine and Pharmacy, Bucharest,  Romania, Musat Gabriela , Decusara Roxana ,   Carol Davila University of Medicine and Pharmacy, Bucharest, Romania, Musat Ovidiu ,   Carol Davila University Emergency Central Military Hospital, Bucharest, Romania
Published: April 2022

Cogan syndrome is a rare disease characterized by the concomitance of non-syphilitic interstitial keratitis with Meniere-like vestibulo-auditory symptoms. There are criteria for the diagnosis of both typical and atypical Cogan syndrome. We present the case of a 40 years old woman with sudden onset of hearing loss, tinnitus, intense vertigo, instability associated with kerato-conjunctivitis. The concomitance of the symptoms, the onset, and the evolution under treatment are consistent with the diagnosis of atypical Cogan syndrome.
Local treatment options for management of loco-regional esophageal squamous cell carcinoma
Authors:   Dışkapı Yıldırım Beyazıt Research and Education Hospital, Ankara, Turkey, Eren Tülay , İmamoğlu Gökşen ,   Dışkapı Yıldırım Beyazıt Research and Education Hospital, Ankara, Turkey, Yildiz Fatih ,   Ankara Onkoloji Research and Education Hospital, Ankara, Turkey, Arslan Süheyla ,   Yıldırım Beyazıt University, Ankara, Turkey, Kocacan Sultan ,   Dışkapı Yıldırım Beyazıt Research and Education Hospital, Ankara, Turkey, Çakar Salih ,   Numune Research and Education Hospital, Ankara, Turkey, Yazici Ozan ,   Numune Research and Education Hospital, Ankara, Turkey, Yazılıtaş Doğan ,   Dışkapı Yıldırım Beyazıt Research and Education Hospital, Ankara, Turkey, Özdemir Nuriye ,   Yıldırım Beyazıt University, Ankara, Turkey, Öksüzoğlu Berna ,   Ankara Onkoloji Research and Education Hospital, Ankara, Turkey
Published: April 2022

Aim: Surgical treatment is the main treatment method for esophageal cancer. The prognosis is poor due to high local recurrence and distant metastasis rates. Study aims to evaluate the most effective local treatment modality esophageal squamous cell carcinoma (SCC) according to real life data. Method: 136 patients were studied retrospectively. All patients were middle or lower esophageal cancer and had the SCC histology. Patients were divided into the surgical resection, definitive CRT (dCRT), and multimodal treatment groups according to curative local treatment they received. Result: 32.4% were in the surgical, 36% were in the dCRT, and 31.6% were in the multimodal group. Median disease-free survival was 21 months (95% CI 14-27) in the surgical group, 8 months (95% CI 4-11) in the dCRT group, and 18 months (95% CI 0-39) in the multimodal group (p=0.059). The median overall survival was found to be 40 months (95% CI 0-92) in the surgical group, 19 months (95% CI 15-22) in the dCRT group, and 54 months (95% CI 11-96) in the multimodal group (p=0.012). In multimodal group, the number of patients receiving preoperative CRT was 25, and postoperative CRT was 18. Median OS was 47 months (95% CI 0-99) in the preoperative CRT group, and 64 months (NA) in the postoperative CRT group (p=0.302). Conclusion: DFS and OS contributions of multimodal treatment in esophageal SCC have been shown in the present study. The addition of CRT to surgery in the preoperative or postoperative period has a contribution independently of the treatment sequence.
Development of quantitative real-time RT-PCR assay for detection and viral load determination of Crimean-Congo Hemorrhagic Fever (CCHF) virus
Authors:   Applied Virology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran, Sharti Mojtaba , Hashemzadeh Mohammad ,   Applied Virology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran, Dorostkar Ruhollah ,   Applied Virology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran
Published: April 2022

Background and Aim: The CCHF (Crimean-Congo hemorrhagic fever) virus causes a severe disease in human with a case fatality rate of up to 50%. Since, there is no specific treatment or approved vaccine against CCHF viral infections, an accurate and early detection as well as a reliable surveillance and quantitative determination of viral load is necessary for patient improvement and case management. In this research, our aim was to develop a probe based one-step real-time reverse-transcription polymerase chain reaction (rRT-PCR) assay for in-house quantitative detection of CCHF virus. Methods: At first, the highly conserved S-fragment sequence of CCHF virus genome was adapted from GenBank and the specific probe and primers targeting this region were designed. Then, viral RNAs were extracted from 37 blood samples of different patients from east of Iran (Zahedan). The specificity and sensitivity of the probe and primers were also evaluated in positive blood samples, confirmed to have CCHF virus. A standard (PTG19-T vector containing S-fragment) for quantization was also constructed and the viral load was determined in some of positive samples. Results: From a total of 37 suspicious blood samples, 15 samples were confirmed to be positive for CCHF virus by this probe based one-step rRT-PCR assay and no false-positive result was detected according to sequencing data. The predicted fragment of 176 bp was also confirmed in all positive samples by gel-based electrophoresis analysis. The assay was linear between 10 to 103 copy numbers per each microliter of extracted plasmid for this technique and the viral load determined in one of patient blood samples was 55,000 viral particles per each milliliter, for example. Bioinformatics and experimental evaluations approved the specificity of this assay. The LOD of the assay was 10 (or fewer) copy numbers of viral genome per each microliter of the extracted genome. Conclusions: This research showed that the developed probe based one-step rRT-PCR assay is a specific, rapid, sensitive and the simple tool for detection and viral load determination of the CCHF virus. Keywords: CCHF Virus, Real-time RT-PCR, Quantitative, viral load, S-region.
The Impact of COVID-19 on the Volatility of BRICS Stock Returns
Authors: Alkayed Hani , Yousef Ibrahim , Zalmout Ola
Published: April 2022

This study analyzes for the first time the impact of the novel coronavirus known as COVID-19 on stock market volatility for the BRICS countries (Brazil, Russia, India, China, and South Africa) using the GJR-GARCH model. We find that during the coronavirus period, Brazil, India, and South Africa exhibit very high volatility, with negative returns exceeding those faced by these indices during the 2008 financial crisis. On the other hand, the Russian and Chinese indices are shown to have faced greater volatility during the 2008 crisis than they have so far exhibited due to coronavirus. Furthermore, the results of the GJR-GARCH models show that COVID-19 variable has a significant positive impact on stock market volatility for Brazil, India, China, and South Africa but an insignificant impact for Russia. Moreover, of these nations, Brazil has thus far been most heavily affected by the virus, followed by South Africa, China, and India.
Understanding the mediating role of teacher inquiry when connecting learning analytics with design for learning
Authors: Alhadad Sakinah S. J. , Thompson Kate
Published: April 2022

Discussion amongst the learning analytics community is for the need to link learning analytics with learning design. However, learning design is a complex space, and not all approaches to design for learning are the same. With this proposed integrated practice comes unique challenges for the contemporary educator. In this paper, we focus on the underlying processes of teacher inquiry when connecting design for learning with learning analytics. We propose that valuable connection between learning analytics and design for learning is only realised through the mediation of effective teacher inquiry processes. Hence, we aim to better understand these processes in order to identify teachers’ developmental needs. To this end, we propose a working model and examine learners (as educators) inquiry process in a professional learning workshop. We conclude with implications for the proposed model and professional learning.
A review of ten years of implementation and research in aligning learning design with learning analytics at the Open University UK
Authors: Rienties Bart , Nguyen Quan , Holmes Wayne , Reedy Katharine
Published: April 2022

There is an increased recognition that learning design drives both student learning experience and quality enhancements of teaching and learning. The Open University UK (OU) has been one of few institutions that have explicitly and systematically captured the designs for learning at a large scale. By applying advanced analytical techniques on large and fine-grained datasets, the OU has been unpacking the complexity of instructional practices, as well as providing conceptual and empirical evidence of how learning design influences student behaviour, satisfaction, and performance. This study discusses the implementation of learning design at the OU in the last ten years, and critically reviews empirical evidence from eight recent large-scale studies that have linked learning design with learning analytics. Four future research themes are identified to support future adoptions of learning design approaches.
PERENCANAAN PENERAPAN TEKNOLOGI INFORMASI PADA RBTV YOGYAKARTA DALAM MENGHADAPI ERA PENYIARAN DIGITAL
Authors: Prasetyo Lilik Jatmiko , Soedijono Bambang , Huizen Roy Rudolf
Published: April 2022

Dalam menghadapi era penyiaran digital mendatang, sebuah perencanaan yang tepat perlu dilaksanakan oleh lembaga penyiaran agar mampu menghadapi persaingan. Penelitian ini bertujuan untuk mengetahui perencanaan strategis penerapan Teknologi Informasi yang digunakan RBTV dalam menghadapi persaingan yang semakin berat di era penyiaran digital mendatang. Penelitian diawali dengan mengetahui strategi bersaing yang diterapkan oleh RBTV saat ini selanjutnya menganalisis lingkungan perusahaan RBTV, dan membuat formulasi strategi untuk mendapatkan alternatif stategi dengan pemanfaatan Teknologi Informasi sebagai pertimbagan bagi RBTV. Perumusan strategi dikerjakan dengan menggunakan matriks EFE, IFE, SWOT, IE, dan QSPM. Dengan diagram SWOT posisi RBTV berada pada sel 3 yang menunjukkan pada stategi WO (Weakness Opportunities) sehingga salah satu stategi yang menarik untuk dijalankan adalah memanfaatkan jaringan internet untuk bersiaran melalui streaming guna menhadapi konvergensi teknologi informasi dan komunikasi. Berdasarkan matriks QSPM stategi yang paling menarik untuk dijalankan adalah strategi pengembangan produk salah satunya dengan memanfaatkan teknologi Virtual Studio sehingga mendukung dalam menambah jumlah dan variasi program acara pada RBTV.

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Kata kunci: Televisi Digital, RBTV, SWOT, Matriks IE, QSPM
PERANCANGAN DATA WAREHOUSE AKADEMIK STMIK KADIRI
Authors: Fadilah Umi , Winarno Wing Wahyu , Amborowati Armadyah
Published: April 2022

Penelitian ini membahas masalah perancangan data warehouse serta pengimplementasiaannya. Sumber data yang digunakan adalah database akademik yang ada di STMIK Kadiri dan data warehouse yang dibangun berdasarkan tabel fakta mahasiswa. Metode yang digunakan adalah metode penelitian tindakan yaitu menggunakan action research diantaranya tahap Observe, tahap Reflect, Plan dan Act. Di dalam tahap-tahap tersebut dimulai dari merencanakan subyek data, merancang skema bintang, merancang data warehouse kemudian diimplementasikan dengan cara Extract, Transform, load membentuk cube dan menyajikan data untuk laporan yang dibutuhkan manajemen. Hasil dari penelitian ini adalah rancangan data warehouse akademik yang sesuai dengan STMIK Kadiri dan menghasilkan laporan tentang jumlah mahasiswa per angkatan, per jenis kelamin dan per kota asal mahasiswa. Data warehouse ini dibangun dengan SQL Server 2008 dan penyajian data dengan Excel Powerpivot.

Kata Kunci : Database, Data Warehouse, ETL, Powerpivot, Skema Bintang
Analisis Penerapan Sistem Informasi Akademik STIKES Muhammadiyah Gombong
Authors: Ndarbeni Ana Wati , Winarno Wing Wahyu , Sunyoto Andi
Published: April 2022

Penggunaan teknologi informasi tidak hanya untuk keperluan individu saja. Organisasi juga menggunakan teknologi informasi guna membantu proses pelayanan agar berjalan dengan baik. STIKES Muhammadiyah Gombong merupakan lembaga pendidikan kesehatan, yang menggunakan teknologi informasi, berupa sistem informasi akademik (SIMAK). SIMAK bertujuan untuk membantu pelayanan akademik kepada mahasiswa. Penelitian ini menggunakan model gabungan Unified Theory of Acceptance and Usage of Technology (UTAUT) dan Task Technology Fit (TTF) untuk menganalisis penerapan SIMAK di STIKES Muhammadiyah Gombong. Hasil penelitian menunjukkan variabel kebiasaan dan variabel kesesuaian tugas dan teknologi berpengaruh langsung terhadap penerimaan pengguna SIMAK.

Kata kunci � SIMAK, UTAUT, TTF
Film Animasi 2 Dimensi Dengan Judul Andi Tema: Sikap Dan Perilaku Disiplin Anak Usia Dini
Authors: Setyawan Taguh , Juniadi M. Nur , Rosyidi Afnan
Published: April 2022

Metode pembelajaran dalam dunia pendidikan sudah berkembang dan semakin maju, untuk itu berbagai institusi pendidikan berupaya menciptakan sumber daya manusia yang berkualitas dengan menerapkan metode pembelajaran yang beragam, diantaranya metode pembelajaran berbasis film animasi. Metode ini dirasa bermanfaat bagi anak usia dini, karena media film kartun animasi pada umumnya disenangi oleh anak-anak karena karakter gambar animasi yang menarik.Untuk itu lembaga pendidikan dan orang tua dirasa perlu untuk ikut menerapkan metode pembelajaran berbasis animasi, dan untuk itulah penulis membuat tugasakhir perancangan Film animasi 2 dimensi untuk membantu lembaga pendidikan dan orang dalam mencapai tujuannya mengembangkan kepribadian terpuji dan potensi diri pada anak. Film animasi ini merupakan salah satu media pengajaran yang dapat digunakan untuk membantu dalam meningkatkan pemahaman anak tentang suatu peristiwa atau kejadian, nilai dan pesan yang disampaikan, juga untuk melatih kedisiplinan dan kesadaran anak terhadap perilaku dan tindakannya.
Pengenalan Google Firebase Untuk Hybrid Mobile Apps Berbasis Cordova
Authors: Ilhami Mirza
Published: April 2022

Seringkali para pengembang memiliki keterbatasan ketika mengembangkan aplikasi yang didukung di beberapa platform. Dikarenakan, Android native dan iOS native memiliki bahasa pemrograman yang berbeda. Java untuk Android, sedangkan Swift untuk iOS. Tentu para pengembang harus menguasai dua bahasa pemrograman tersebut untuk membangun aplikasi dikeduanya. Ini tentu tidak efisien dari segi waktu. Karena itu, adanya teknologi hybrid apps sangat menghemat waktu para pengembang, karena hybrid app dapat bekerja di multiplatform. Pengembang aplikasi cukup membangun satu aplikasi dan kemudian menjalankannya di platform Android and iOS. Kendala lainnya yang sering dijumpai pengembang aplikasi adalah ketika mengembangkan REST API untuk aplikasi yang dibangun. Perlu menguasasi bahasa pemrograman berbasis server seperti PHP atau ASP agar mampu membangun API yang baik. Ditambah lagi dengan membangun database relasional seperti MySQL atau PostgreSQL untuk menyimpan data dari aplikasi yang dibangun. Penelitian inimengimplementasikan bagaimana hybrid apps dapat berjalan di multi platform dan memanfaatkan Google Firebase sebagai database tanpa harus menggunakan database relasional seperti SQL. Google Firebase menyediakan REST API yang dapat diakses langsung melalui hybrid apps tanpa perlu membangun API menggunakan pemrograman berbasis server. Ujicoba dilakukan dengan beberapa fitur dari Google Firebase seperti Autentikasi, Realtime Database, Storage dan Cloud Messaging.

Kata kunci�hybrid apps, google firebase, android, ios
APLIKASI SISTEM PEMBAYARAN PENDIDIKAN DAN PRASARANA DENGAN JAVA
Authors: Andriani Imei Lutfi , Andri KR Rum M.
Published: April 2022

Sistem pembayaran pendidikan dan prasarana yang diterapkan di Madrasah Aliyah Negeri Wonogiri belum sepenuhnya terkomputerisasi (masih mencatat pembayaran dibanyak buku dan Ms.Excel) sehingga pelaporannya belum bisa tepat waktu. Tujuan studi ini adalah mengatasi permasalahan dengan mengembangkan aplikasi pembayaran pendidikan dan prasarana dengan bahasa pemrograman Java. Hasilnya aplikasi tersebut dapat membantu bendahara menghasilkan laporan secara tepat waktu.

Kata kunci: Aplikasi sistem pembayaran, Java, tepat waktu
Pengaruh Penerapan Kualitas Kegunaan, Kualitas Informasi dan Kualitas Interaksi Website Terhadap Kepercayaan Konsumen Hotel Di Kabupaten Banyumas
Authors: Berlilana Berlilana , Suyanto M. , Luthfi Emha Taufiq
Published: April 2022

Tujuan penulisan adalah untuk mengetahui pengaruh kualitas kegunaan, kulitas informasi dan kualitas interaksi website terhadap tingkat kepercayaan konsumen (Customer Trust). Pemilihan responden adalah tamu-tamu pada hotel yang menggunakan travel agent online untuk reservasi. Ukuran sampel ditentukan dengan metode Slovin, berdasarkan metode tersebut diperoleh ukuran sampel 205. Ukuran sampel ini sudah memenuhi syarat dalam analisis data dengan teknik structurel equation model dengan software AMOS, yaitu ukuran sampel minimal lima kali banyaknya indikator yang digunakan yaitu minimal 5 x 18 = 90 responden. Ketentuan lainnya adalah sepuluh kali banyaknya indikator yang digunakan yaitu minimal 10 x 18 = 180 responden. Analisis data dengan menggunakan metode Structural Equation Model (SEM) yang terdiri dari 7 tahap. Data yang diolah dengan teknik structural equation modelling (SEM) menggunakan software AMOS 22 mendapatkan hasil terdapat pengaruh positif kualitas kegunaan (Kkeg), kualitas informasi (Kinf) dan kualitas interaksi(Kint) terhadap kepercayaan konsumen (Kkep).

Kata Kunci : Website, kepercayaan konsumen, structural equation modelling (SEM)
Evaluasi Kepatuhan Logical dan Physical Security Terhadap Kebijakan Pengamanan Data
Authors: Isnaini Khairunnisak Nur , Winarno Wing Wahyu , Henderi Henderi
Published: April 2022

Aset IT yang dimiliki oleh sebuah perusahaan atau instansi seharusnya dapat dijaga dengan baik agar terhindar dari kerusakan, pencurian, dan hal-hal yang merugikan lainnya. Penelitian ini dilakukan untuk mengukur tingkat kepatuhan karyawan terhadap kebijakan pengamanan data terutama pada aspek logical security, kontrol password, dan physical security di STMIK XYZ. Penelitian ini menggunakan metode kuantitatif deskriptif. Pengumpulan data dilakukan dengan cara studi dokumentasi, wawancara, pembagian kuisioner yang disebar kepada seluruh karyawan berdasarkan tabel RACI Chart. Selanjutnya penulis melakukan pengolahan data statistik berupa uji validitas dan realibilitas untuk menguji konsistensi kuisioner yang dibagikan serta melakukan analisa kesenjangan antara kondisi saat ini dan kondisi harapan. Domain DSS5.4 (manage user identity and logical access) dan DSS5.5(manage physcal access to IT assets) pada Famework COBIT 5 digunakan sebagai alat ukur menilai indeks tingkat kepatuhan karyawan. Hasil yang diperoleh menunjukkan bahwa tingkat kepatuhan karyawan secara umum berada pada level 3 (Established Process) yang berarti karyawan telah menerapkan kebijakan, standar dan operasional prosedur. kondisi kesenjangan di atasi dengan pemberian rekomendasi yang tepat kepada pihak-pihak terkait agar kebijakan saat ini dapat diperbaiki atau ditambah sesuai dengan hasil analisis dan standar yang berlaku.

 Kata Kunci:Kebijakan Pengamanan Data, Tingkat Kepatuhan Karyawan, COBIT 5, Analisis Kesenjangan, Rekomendasi
Implementasi DISC Pada Sistem Psikotest Seleksi Peserta KKL STMIK Amikom Purwokerto
Authors: Santiko Irfan , Prasetyo Agung , Novianthy Pradita
Published: April 2022

Kuliah Kerja Lapangan sebagai salah satu mata kuliah pilihan yang ada di STMIK Amikom Purwokerto, dimana mata kuliah ini dapat diambil setelah menempuh 5 semester. Ada beberapa tahapan seleksi yang petama yaitu pendaftaran kemudian psikotes untuk menentukan tipe kepribadian guna membentuk suatu kelompok, alat yang digunakan untuk mengukur tipe kepribadian menggunakan teori DISC (Dominance – Influence -  Steadiness - Compliance). Setiap karakter DISC memiliki respon yang berbeda-beda terhadap tekanan yang dialaminya di dalam lingkungan, karna sifatnya yang terjun langsung ke masyarakat maka diperlukan sistem untuk membantu pembentukan kelompok berdasarkan hasil psikotes. Peneliti membuat aplikasi psikotes berbasis web untuk memudahkan calon peserta kuliah kerja lapangan dalam mengerjakan ujian dan membantu penyelenggara kuliah kerja lapangan dalam menentukan kelompok berdasarkan hasil psikotes. Peneliti dalam pengumpulan data menggunakan teknik observasi, wawancara, kuesioner, dan studi pustaka. Metode pengembangan sistem yang digunakan adalah metode waterfall.

 
Kata Kunci : Kuliah Kerja Lapangan, Psikotes, DISC.
Perancangan Sistem Informasi Desa Terintegrasi Studi Kasus Desa Melung
Authors: Rifai Zanuar , Bratakusuma Trias , Arvianti Ratna
Published: April 2022

Saat ini penerapan e-Government hanya sebatas pada pemerintah di tingkat kabupaten dan belum menjangkau pemerintah desa yang komprehensif. Di beberapa desa telah menerapkan system informasi khusus yang digunakan untuk menangani administrasi desa, namun demikian dalam melakukan pelayanan administrasi tetap masih konvensional. Kekurangan dari proses ini adalah jika surat yang diminta membutuhkan pengesahan resmi (kepala desa), sedangkan yang bersangkutan tidak ada di tempat maka pemohon akan kembali ke balai desa nanti, hal ini berarti ada waktu tunggu yang harus dialami oleh pemohon. Ini akan sangat membuang waktu, pemohon dan juga layanan hanya berlaku selama jam kantor saja dan juga para pemohon tidak bias memonitoring proses surat yang diajukan. Ini akan sangat membuang waktu pemohon dan juga karena pemberian layanan hanya berlaku selama jam kantor saja maka proses menjadi tidak efektif dan efisien. Salah satu cara yang dapat dilakukan untuk menanggulangi permasalahan diatas adalah dengan membuat Prototype Sistem Monitoring Layanan Terintegrasi berbasis REST guna mengoptimalisasi penggunaan data-data yang ada di pemerintahan desa dan mengembangkan sistem monitoring layanan administrasi yang dapat terintegrasi dengan berbagai sistem lainnya seperti: Sistem administrasi desa, Sistem pembayaran PBB Pemda dan Sistem kependudukan Dindukcapil guna mendukung pengintegrasian sistem dalam mencapai e-government desa yang terpadu sehingga dapat mendukung akurasi dan percepatan pemberian layanan .Metode pengembangan sistem pada penelitian ini adalah menggunakan prototype
SISTEM INFORMASI INVENTARIS SARANA DAN PRASARANA BERBASIS WEB UNIVERSITAS ANDI DJEMMA
Authors: Yanto Fachrurozi Friedi , Suppa Rinto , Sulaeman Budiawan
Published: April 2022

Penelitian ini mengarah pada merancang dan membangun aplikasi inventaris sarana dan prasarana berbasis web pada Universitas Andi Djemma. Sistem inventaris yang dilakukan Universitas Andi Djemma, belum memilki sistem (aplikasi) yang mengelola data sarana dan prasarana yang cukup memadai di mana untuk sekarang ini masih manual dan sistemnya masih kurang memadai serta belum lengkap sehingga data yang dikelola kurang terinventarisir, data tidak akurat dikarenakan keterbatasan sistem yang berjalan saat ini. Sistem informasi inventaris sarana dan prasarana ini menggunakan model waterfall dalam tahap pengembangan sistem. Untuk mengumpulkan data peneliti melakukan wawancara, dokumentasi data, dan observasi. Merancang sistem mengguakan model UML seperti diagram use case, diagram activity, diagram sequence, dan class diagram. Bahasa pemrograman yang digunakan adalah PHP dan database MySQL. Hasil penelitian ini adalah sistem informasi inventaris sarana dan prasarana secara online sehingga mempermudah pendataan sarana dan prasarana untuk mengelola data agar lebih terinventarisir.
APLIKASI PANDUAN KESEHATAN IBU DAN ANAK BERBASIS ANDROID ( STUDI KASUS : POSYANDU SEMERU LUMANDI )
Authors: Asshiddiq Hikmah , Dani Ahmad Ali Hakam , Suppa Rinto
Published: April 2022

Penelitian ini bertujuan untuk merancang dan membangun suatu sistem aplikasi Kesehatan Ibu dan Anak (KIA) berbasis android pada Posyandu Semeru Lumandi. Metode penelitian yang digunakan adalah metode kualitatif dengan teknik pengumpulan data menggunakan metode wawancara, observasi dan studi pustaka. Aplikasi kesehatan ibu dan anak dalam perancangannya menggunakan metode pengembangan UML (Unified Modeling Language) yang terdiri dari use case diagram, activity diagram, sequence diagram dan class diagram. Perancangan database menggunakan MySQL. Adapun software yang di gunakan dalam perancangan dan pengimplementasi sistem menggunakan XAMPP sebagai webserver, PhpMySQL sebagai database,Sublime text sebagai editor pengkodean program, Android Studio sebagai media membuat aplikasi android. Aplikasi Kesehatan Ibu dan Anak meliputi informasi kesehatan ibu dan anak, jadwal posyandu, catatan kesehatan ibu dan anak, kms, data pengguna, konsultasi, Sistem informasi telah di ujicoba menggunakan pengujian blackbox sehingga diperoleh sistem yang dapat membantu kader/bidan untuk bekerja secara lebih fleksibel dan juga memudahkan masyarakat yang masuk dalam wilayah kerja Posyandu Semeru Lumandi untuk mendapatkan informasi kesehatan yang lebih terbaru.
THE EFFECT OF PRODUCT QUALITY, PRICE AND DISTRIBUTION ON THE PURCHASE DECISION OF AVIATOR BRAND BIKE (Survey of Bike Shops in Bangkinang City)
Authors: Andriano Andriano , Arman Arman , Azhari Azhari , Putra Royansyah
Published: April 2022

This study aims to determine the effect of product quality, price and distribution simultaneously and partially on the purchasing decision of bike aviator (Survey at a bicycle shop in Bangkinang city). The types and sources of data used in this study are primary data and secondary data, while the data collection technique is using questionnaires, research files, observations, the analysis used in this study is multiple linear analysis with a sample of 100 people. The sample collection technique is by using accidental sampling technique. Based on the results of simultaneous tests, product quality, price and distribution variables have a joint effect on purchasing decisions for aviator brand bicycles (a survey at bicycle shops in Bangkinang Kota), while based on a partial test, product quality, price and distribution variables have been shown to have a significant effect on their own. -self to the decision to purchase an aviator brand bicycle (a survey at a bicycle shop in Bangkinang City, the closeness of the relationship that occurs between the variables of product quality, price and distribution on purchasing decisions is very strong. Meanwhile, the contribution of the independent variable to the dependent variable is 78.90%
“Kotoba Rollers” walkthrough: Board games, TBLT, and player progression in a university EFL classroom
Authors: York James
Published: April 2022

This paper presents a detailed walkthrough of a pedagogical intervention that utilizes board games as part of a TBLT approach to language teaching in a compulsory university classroom context. The context, teacher and participants are introduced before a thorough explanation of the intervention. Theoretical underpinnings and teacher decisions are introduced including how the model relates to broad literature on education, particularly Squire’s (2011) conceptualization of learners and player progression. Subsequently, a “playtest” of the model is presented with a focus on teacher mediation and students’ progression. Student work appears in the form of presentation slides, survey data, photos of the accompanying workbook (made specifically for this context), and final project products. The model, materials, and teacher mediation promoted students to become self-directed learners, successfully carrying out gameplay and analysis activities which led to language and 21st Century skills development. Successful (and not so successful) examples of student progression from learner to content creator are provided. Finally, a critical analysis of the model is presented, and it is proposed that the model could be developed to focus on specific skills or help learners engage in English-speaking communities outside the classroom.
BORZYKOWSKI’S IMMUNITY PRIVILEGE – ON THE WAY TO THE EMANCIPATION OF THE CHURCH IN PIAST POLAND
Authors: Lis Artur
Published: April 2022

The reason for calling the synod in Borzykowa was the bull “Significavit nobis” issued in 1210 by Pope Innocent III, which renewed the principle of seniority. At the synod, the possibilities of counteracting the effects of this bull were discussed. The bishops were also to approve Leszek the White’s right to hold the Kraków throne. During the synod, prince Władysław Odonic granted the Cistercian order a land in the castellany of Przemyśl in order to establish a monastery. In turn, the knight Sławosz resumed granting Sławoszów to the monastery in Busko. According to historiography, the dukes issued a set of privileges, including a great privilege for the Church (privilegium fori, ius spolii). The Borzykowski privilege became the basis for the independence of the Church from the Piast monarchy in district Poland
THE PRINCIPLE OF COMPLICITY IN INTENTIONAL SELF-INFLICTED INJURY AS A NEGATIVE PREMISE FOR THE OBJECTIVE ATTRIBUTION OF AN EFFECT FROM THE PERSPECTIVE OF CRIMES AGAINST LIFE AND HEALTH IN POLISH AND GERMAN CRIMINAL LAW
Authors: Kiełbas Dominika
Published: April 2022

The subject of the present article is the principle of complicity in intentional self-inflicted injury as a negative premise for objective attribution of an effect from the perspective of crimes against life and health in Polish and German criminal law. First, the problem of negative prerequisites for objective attribution of an effect is briefly discussed, which is an extremely interesting issue both from the perspective of dogmatics and the practice of criminal law. Then the article brings closer the criterion of the principle of victim autonomy by means of examples taken from the German doctrine and jurisprudence in the area of crimes against life and health and analyses them from the perspective of the Polish Penal Code. The whole allows to get acquainted with the discussed premise and to understand both its theoretical essence and a somewhat illustrative exemplification
EVALUATION OF THE WHISTLEBLOWER PROTECTION DIRECTIVE IN THE LIGHT OF POLISH PREPARATIONS FOR THE TRANSPOSITION OF THE REPORTING MODEL
Authors: Kobroń-Gąsiorowska Łucja
Published: April 2022

On October 23, 2019, the European Union adopted the Directive on protecting whistleblowers. The Directive was intended to be a groundbreaking tool in protecting whistleblowers. The Directive introduces essential and correct standards to protect the interests of the European Union and whistleblowers who report breaches of EU law. The whistleblower protection model is designed to go beyond any standards of whistleblower protections in the Member States. Nevertheless, the effectiveness of the Directive is difficult to assess without complete transposition in the Member States. The process did not end with the saying as of December 17, 2021 in Poland, which is only at the draft bill stage. The author notes that the Directive does not provide a comprehensive model for reporting irregularities, which results in an incomplete conceptualization of this institution.
DIVERSIFYING THE TAX SITUATION OF EMPLOYEES WHO ARE AND ARE NOT RESIDENTS OF AN EU MEMBER STATE – IN THE LIGHT OF THE THE COURT OF JUSTICE
OF THE EUROPEAN UNION URISPRUDENCE
Authors: Szuba Marzena
Published: April 2022

This study attempts to analyze the situation of employees who are not tax residents of the country in which they perform paid work - in the context of tax liabilities. First, the significance of the principle of non-discrimination and free movement of workers, as extremely important for the discussed subject, was discussed. Then, the analysis covered the possibility of differentiating the tax situation of employees who are entitled to tax resident status in a given Member State and those who do not have such status – in the light of the the court of justice of the european union jurisprudence. In particular, situations in which it is not possible to treat the above-mentioned entities differently were taken into account. Finally, the ruling of the the court of justice of the european union that was presented was assessed.
Preliminary Economic Potential Evaluation of Seaweed Gracilaria sp. Biomass Waste as Bioindustry Feedstock Through a Biorefinery Approach: A Case Study in Karawang, Indonesia
Authors: Fadhlullah Muhammad , Prasetyati Sukma Budi , Pudoli Imam , Lo Calvin
Published: April 2022

Seaweed processing usually produces biomass waste from unused and rejected materials, which have economic potential due to their bioactive components. This preliminary study aims to evaluate the economic potential of seaweed biomass waste through a biorefinery approach. Seaweed Gracilaria sp. biomass waste samples were collected from a representative seaweed production unit in Karawang, Indonesia, and their biochemical composition was analyzed. Relevant information related to seaweed biomass waste was gathered. The preliminary economic evaluation was assessed from the gross revenue of the proposed products, based on the assumed annual seaweed biomass waste productivity, biochemical composition, and estimated market price of the products. The present study revealed that the dry weight of Gracilaria sp. biomass waste contains 63.2% carbohydrates, 13.6% proteins, 1.6% lipids, and 21.5% ashes. Heavy metals were detected in the biomass waste, although no pigments were detected. This study estimates that 52 metric tons/year of Gracilaria sp. biomass waste could generate amino acids, fatty acids, lipids, carbohydrates, and minerals with potential gross revenue of ± USD 222,924.6/year. This study suggests that Gracilaria sp. biomass waste could be potentially used as feedstock to improve its economic value for bioindustry purposes.
Introduction
Authors: Congram Derek
Published: April 2022

N/A
Neuropsychologisches Coaching
Authors: Krämer Raphael , Schöppe Lars
Published: April 2022

Neuroscience from a coaching perspective: How can findings of todays neurosciences be used efficient for coaching? What does research know about the brain, our emotions and our behaviour?

Neuropsychological research has made a lot of progress and in coaching, too, more and more evidence for effective processes is building up. In this thesis the two authors offer a concept for the integration of neuroscientific findings for successful coaching processes.
The Role of Executive Functions in the Relationship Between Loneliness and Psychological Well-Being of the Elderly
Authors: Etemadi Shamsabadi Amir , Keshavarz Gerami Ghasem , Etemadi Shamsabadi Paria
Published: April 2022

Background: Perceived loneliness has insinuation in both cognitive and well-being of individuals. Loneliness is a major risk factor for depressive disorder. Decreased executive function is a significant problem for older adults that plays an essential role in their psychological well-being. Objectives: This study aimed to investigate the role of executive functions in the loneliness and psychological well-being of the elderly. Methods: The present correlational study with a survey research design used structural equation modeling. The sample size was 115 people selected using purposeful sampling. The Ryff’s psychological well-being questionnaire, executive function tests (including N-Back, Trail Making Test, quantitative calculations, London Tower, and Reaction Time), and the DiTomasso Social and Emotional Loneliness Scale for Adults were used to collect information required for this research. Results: Model fit indices showed that the conceptual model extracted based on theoretical foundations had an acceptable fit (RMSEA = 0.047). The analysis results showed that executive functions played a mediating role in the relationship between perceived loneliness and psychological well-being. The perceived loneliness showed a significant inverse relationship with executive functions and psychological well-being, but executive functions had a direct relationship with psychological well-being. Conclusions: In the present study, it was found that executive functions played a mediating role in the relationship between psychological well-being and the perceived loneliness of the elderly, and these findings are consistent with previous research and theoretical foundations. Further research is suggested to determine biological mechanisms underlying the relationship between perceived loneliness and executive functions with psychological well-being.
Leibniz’s Appropriation of Spinoza’s Argument against Mind-Body Causation
Authors: Favaretti Camposampiero Matteo ,   The Leibniz Society of North America
Published: April 2022

In a 1687 letter to Arnauld, Leibniz draws on an argument against mind-body causation that is reminiscent of one from Spinoza’s Ethics. According to this argument, mind-body causation is impossible because of the lack of proportion between thoughts and motions. This paper aims to shed light on Leibniz’s use of Spinoza’s argument by reconstructing both its internal structure and its development in Leibniz’s later works. In particular, the reconstruction focuses on the new version of this argument that Leibniz adopts against Stahl’s vitalism as well as on the change that this new version reveals in Leibniz’s attitude towards occasionalism. The possible influence of Cordemoy is also taken into consideration. The epistemological and metaphysical issues surrounding this argument are an essential part of the history of Leibniz’s psycho-physical parallelism.
Academic Internships in Philosophy
Authors: Choe-Smith Chong ,   Philosophy Documentation Center
Published: April 2022

Academic internships are increasingly common in other disciplines, but have not been discussed or implemented widely in the discipline of philosophy. This article fills this gap by discussing the potential benefits of philosophy internships and addressing two important questions: whether there is something different about philosophy—possibly its abstractness, versatility, or what I refer to as “pluripotency”—that renders the benefits of internships out of reach for many philosophy students, and whether philosophy faculty should be responsible for developing and implementing philosophy internships. In this article, I argue that there is nothing about the discipline itself that prevents philosophy majors from experiencing the benefits of academic internships and that, among the different possible internship coordinators, philosophy faculty bear primary responsibility for developing academic internships in philosophy and assisting philosophy students as they transition from college to professional career.
High-peak-power orthogonally-polarized dual-wavelength Nd:YLF/BaWO4 Raman laser
Authors: Fan Li , Xiang Ke-Yun , Shen Jun , Zhu Jun ,   Institute of Applied Photonic Technology, College of Physics Science and Technology, Yangzhou University, Yangzhou 225002, China
Published: April 2022

Orthogonally-polarized dual-wavelength laser has significant practical applications in various fields, such as precision metrology, terahertz radiation generation, differential radar, spectral analysis. The Nd:YLF crystal has two orthogonally-polarized emission peaks with comparable emission cross sections, high-energy storage capability and relatively weak thermal lens effect. Owing to these properties, it has been recognized as a suitable gain medium for generating orthogonally-polarized dual-wavelength laser. In this paper, the Nd:YLF crystal with low doping concentration is employed as a laser gain medium to produce 1047 nm and 1053 nm dual-wavelength fundamental lasers with orthogonal polarizations, and the risk of thermal cracking of Nd:YLF crystal is reduced by appropriately increasing the pump spots. Using the intracavity Raman frequency shift in BaWO4 crystal, orthogonally-polarized dual-wavelength Raman lasers at 1159.9 nm and 1167.1 nm are achieved to have high peak power. Under the total incident pump power of 40 W and a pulse repetition rate of 5 kHz, the maximum dual-wavelength Raman output power is obtained to be 2.67 W. The corresponding total optical conversion efficiency is 6.7%. For 1159.9 nm and 1167.1 nm Raman laser, their maximum average output power values are 1.31 W and 1.36 W, respectively. Their narrowest pulse widths are 1.50 ns and 1.53 ns, and the corresponding peak power values are as high as 174.7 kW and 177.8 kW, respectively. The results show that the problem of thermal cracking of Nd:YLF crystal at high pump power can be solved by reducing the doping concentration and increasing the pump spot. The Nd:YLF/BaWO4 is a promising crystal combination for realizing orthogonally-polarized dual-wavelength Raman laser.
Chemoreceptor co-expression in Drosophila melanogaster olfactory neurons
Authors: Task Darya , Lin Chun-Chieh , Vulpe Alina , Afify Ali , Ballou Sydney , Brbic Maria , Schlegel Philipp , Raji Joshua , Jefferis Gregory SXE , Li Hongjie , Menuz Karen , Potter Christopher J
Published: April 2022

Drosophila melanogaster olfactory neurons have long been thought to express only one chemosensory receptor gene family. There are two main olfactory receptor gene families in Drosophila, the odorant receptors (ORs) and the ionotropic receptors (IRs). The dozens of odorant-binding receptors in each family require at least one co-receptor gene in order to function: Orco for ORs, and Ir25a, Ir8a, and Ir76b for IRs. Using a new genetic knock-in strategy, we targeted the four co-receptors representing the main chemosensory families in D. melanogaster (Orco, Ir8a, Ir76b, Ir25a). Co-receptor knock-in expression patterns were verified as accurate representations of endogenous expression. We find extensive overlap in expression among the different co-receptors. As defined by innervation into antennal lobe glomeruli, Ir25a is broadly expressed in 88% of all olfactory sensory neuron classes and is co-expressed in 82% of Orco+ neuron classes, including all neuron classes in the maxillary palp. Orco, Ir8a, and Ir76b expression patterns are also more expansive than previously assumed. Single sensillum recordings from Orco-expressing Ir25a mutant antennal and palpal neurons identify changes in olfactory responses. We also find co-expression of Orco and Ir25a in Drosophila sechellia and Anopheles coluzzii olfactory neurons. These results suggest that co-expression of chemosensory receptors is common in insect olfactory neurons. Together, our data present the first comprehensive map of chemosensory co-receptor expression and reveal their unexpected widespread co-expression in the fly olfactory system.
Neocortical pyramidal neurons with axons emerging from dendrites are frequent in non-primates, but rare in monkey and human
Authors: Wahle Petra , Sobierajski Eric , Gasterstädt Ina , Lehmann Nadja , Weber Susanna , Lübke Joachim HR , Engelhardt Maren , Distler Claudia , Meyer Gundela
Published: April 2022

The canonical view of neuronal function is that inputs are received by dendrites and somata, become integrated in the somatodendritic compartment and upon reaching a sufficient threshold, generate axonal output with axons emerging from the cell body. The latter is not necessarily the case. Instead, axons may originate from dendrites. The terms ‘axon carrying dendrite’ (AcD) and ‘AcD neurons’ have been coined to describe this feature. In rodent hippocampus, AcD cells are shown to be functionally ‘privileged’, since inputs here can circumvent somatic integration and lead to immediate action potential initiation in the axon. Here, we report on the diversity of axon origins in neocortical pyramidal cells of rodent, ungulate, carnivore, and primate. Detection methods were Thy-1-EGFP labeling in mouse, retrograde biocytin tracing in rat, cat, ferret, and macaque, SMI-32/βIV-spectrin immunofluorescence in pig, cat, and macaque, and Golgi staining in macaque and human. We found that in non-primate mammals, 10–21% of pyramidal cells of layers II–VI had an AcD. In marked contrast, in macaque and human, this proportion was lower and was particularly low for supragranular neurons. A comparison of six cortical areas (being sensory, association, and limbic in nature) in three macaques yielded percentages of AcD cells which varied by a factor of 2 between the areas and between the individuals. Unexpectedly, pyramidal cells in the white matter of postnatal cat and aged human cortex exhibit AcDs to much higher percentages. In addition, interneurons assessed in developing cat and adult human cortex had AcDs at type-specific proportions and for some types at much higher percentages than pyramidal cells. Our findings expand the current knowledge regarding the distribution and proportion of AcD cells in neocortex of non-primate taxa, which strikingly differ from primates where these cells are mainly found in deeper layers and white matter.
A-type FHFs mediate resurgent currents through TTX-resistant voltage-gated sodium channels
Authors: Xiao Yucheng , Theile Jonathan W , Zybura Agnes , Pan Yanling , Lin Zhixin , Cummins Theodore R
Published: April 2022

Resurgent currents (INaR) produced by voltage-gated sodium channels are required for many neurons to maintain high-frequency firing and contribute to neuronal hyperexcitability and disease pathophysiology. Here, we show, for the first time, that INaR can be reconstituted in a heterologous system by coexpression of sodium channel α-subunits and A-type fibroblast growth factor homologous factors (FHFs). Specifically, A-type FHFs induces INaR from Nav1.8, Nav1.9 tetrodotoxin (TTX)-resistant neuronal channels, and, to a lesser extent, neuronal Nav1.7 and cardiac Nav1.5 channels. Moreover, we identified the N-terminus of FHF as the critical molecule responsible for A-type FHFs-mediated INaR. Among the FHFs, FHF4A is the most important isoform for mediating Nav1.8 and Nav1.9 INaR. In nociceptive sensory neurons, FHF4A knockdown significantly reduces INaR amplitude and the percentage of neurons that generate INaR, substantially suppressing excitability. Thus, our work reveals a novel molecular mechanism underlying TTX-resistant INaR generation and provides important potential targets for pain treatment.