bluuebunny/crossref_metadata_2025 huggingface dataset:
Data from Linking Physical Activity to Breast Cancer Risk via Insulin/Insulin-Like Growth Factor Signaling System, Part 1: The Effect of Physical Activity on the Insulin/Insulin-Like Growth Factor Signaling System
Authors: Swain Christopher T.V. , Drummond Ann E. , Milne Roger L. , English Dallas R. , Brown Kristy A. , Chong Jamie E. , Skinner Tina L. , van Roekel Eline H. , Moore Melissa M. , Gaunt Tom R. , Martin Richard M. , Lewis Sarah J. , Lynch Brigid M.
Published: May 2023

Abstract
Physical activity may reduce the risk of developing breast cancer via its effect on the insulin/insulin-like growth factor (IGF) signaling system. A systematic review searched for randomized controlled trials (RCT), Mendelian randomization and prospective cohort studies that examined the effects of physical activity on insulin/IGF signaling [IGFs, their binding proteins (IGFBP), and markers of insulin resistance] in adult women. Meta-analyses were performed to generate effect estimates. Risk of bias was assessed, and the Grading of Recommendations Assessment, Development, and Evaluation system used to determine the overall quality of the evidence. Fifty-eight RCTs met our inclusion criteria, no observational or Mendelian randomization studies met the criteria for inclusion. Meta-analyses indicated that physical activity interventions (vs. control) reduced fasting insulin, the Homeostatic Model Assessment for Insulin Resistance and fasting glucose. Physical activity increased IGF-1, but there was no clear effect on IGFBP-3 or the ratio of IGF-1:IGFBP-3. Strong evidence was only established for fasting insulin and insulin resistance. Further research is needed to examine the effect of physical activity on C-peptide and HBA1c in women. Reductions in fasting insulin and insulin resistance following exercise suggest some biological plausibility of the first part of the physical activity–insulin/IGF signaling–breast cancer pathway.

See related article by Drummond et al., p. 2116
Data from RNA-Based Classification of Homologous Recombination Deficiency in Racially Diverse Patients with Breast Cancer
Authors: Walens Andrea , Van Alsten Sarah C. , Olsson Linnea T. , Smith Markia A. , Lockhart Alex , Gao Xiaohua , Hamilton Alina M. , Kirk Erin L. , Love Michael I. , Gupta Gaorav P. , Perou Charles M. , Vaziri Cyrus , Hoadley Katherine A. , Troester Melissa A.
Published: May 2023

AbstractBackground:
Aberrant expression of DNA repair pathways such as homologous recombination (HR) can lead to DNA repair imbalance, genomic instability, and altered chemotherapy response. DNA repair imbalance may predict prognosis, but variation in DNA repair in diverse cohorts of breast cancer patients is understudied.
Methods:
To identify RNA-based patterns of DNA repair expression, we performed unsupervised clustering on 51 DNA repair-related genes in the Cancer Genome Atlas Breast Cancer [TCGA BRCA (n = 1,094)] and Carolina Breast Cancer Study [CBCS (n = 1,461)]. Using published DNA-based HR deficiency (HRD) scores (high-HRD ≥ 42) from TCGA, we trained an RNA-based supervised classifier. Unsupervised and supervised HRD classifiers were evaluated in association with demographics, tumor characteristics, and clinical outcomes.
Results
: Unsupervised clustering on DNA repair genes identified four clusters of breast tumors, with one group having high expression of HR genes. Approximately 39.7% of CBCS and 29.3% of TCGA breast tumors had this unsupervised high-HRD (U-HRD) profile. A supervised HRD classifier (S-HRD) trained on TCGA had 84% sensitivity and 73% specificity to detect HRD-high samples. Both U-HRD and S-HRD tumors in CBCS had higher frequency of TP53 mutant-like status (45% and 41% enrichment) and basal-like subtype (63% and 58% enrichment). S-HRD high was more common among black patients. Among chemotherapy-treated participants, recurrence was associated with S-HRD high (HR: 2.38, 95% confidence interval = 1.50–3.78).
Conclusions:
HRD is associated with poor prognosis and enriched in the tumors of black women.
Impact:
RNA-level indicators of HRD are predictive of breast cancer outcomes in diverse populations.
Data from Linking Physical Activity to Breast Cancer Risk via the Insulin/Insulin-like Growth Factor Signaling System, Part 2: The Effect of Insulin/Insulin-like Growth Factor Signaling on Breast Cancer Risk
Authors: Drummond Ann E. , Swain Christopher T.V. , Milne Roger L. , English Dallas R. , Brown Kristy A. , Skinner Tina L. , Lay Jannelle , van Roekel Eline H. , Moore Melissa M. , Gaunt Tom R. , Martin Richard M. , Lewis Sarah J. , Lynch Brigid M.
Published: May 2023

Abstract
Perturbation of the insulin/insulin-like growth factor (IGF) signaling system is often cited as a mechanism driving breast cancer risk. A systematic review identified prospective cohort studies and Mendelian randomization studies that examined the effects of insulin/IGF signaling (IGF, their binding proteins (IGFBP), and markers of insulin resistance] on breast cancer risk. Meta-analyses generated effect estimates; risk of bias was assessed and the Grading of Recommendations Assessment, Development and Evaluation system applied to evaluate the overall quality of the evidence. Four Mendelian randomization and 19 prospective cohort studies met our inclusion criteria. Meta-analysis of cohort studies confirmed that higher IGF-1 increased risk of breast cancer; this finding was supported by the Mendelian randomization studies. IGFBP-3 did not affect breast cancer. Meta analyses for connecting-peptide and fasting insulin showed small risk increases, but confidence intervals were wide and crossed the null. The quality of evidence obtained ranged from ‘very low’ to ‘moderate’. There were insufficient studies to examine other markers of insulin/IGF signaling. These findings do not strongly support the biological plausibility of the second part of the physical activity—insulin/IGF signaling system—breast cancer pathway. Robust conclusions cannot be drawn due to the dearth of high quality studies.

See related article by Swain et al., p. 2106
Data from Plasma miR-151-3p as a Candidate Diagnostic Biomarker for Head and Neck Cancer: A Cross-sectional Study within the INHANCE Consortium
Authors: Pastorino Roberta , Sassano Michele , Danilo Tiziano Francesco , Giraldi Luca , Amore Rosarita , Arzani Dario , Abiusi Emanuela , Ahrens Wolfgang , Vilches Laia Alemany , Canova Cristina , Healy Claire Mary , Holcatova Ivana , Lagiou Pagona , Polesel Jerry , Popovic Maja , Nygård Ståle , Cadoni Gabriella , Znaor Ariana , Boffetta Paolo , Matsuo Keitaro , Oze Isao , Brennan Paul , Boccia Stefania
Published: May 2023

AbstractBackground:
Identification of screening tests for the detection of head and neck cancer (HNC) at an early stage is an important strategy to improving prognosis. Our objective was to identify plasma circulating miRNAs for the diagnosis of HNC (oral and laryngeal subsites), within a multicenter International Head and Neck Cancer Epidemiology consortium.
Methods:
A high-throughput screening phase with 754 miRNAs was performed in plasma samples of 88 cases and 88 controls, followed by a validation phase of the differentially expressed miRNAs, identified in the screening, in samples of 396 cases and 396 controls. Comparison of the fold changes (FC) was carried out using the Wilcoxon rank-sum test and the Dunn multiple comparison test.
Results:
We identified miR-151-3p (FC = 1.73, P = 0.007) as differentially expressed miRNAs in the screening and validation phase. The miR-151-3p was the only overexpressed miRNA in validation sample of patients with HNC with early stage at diagnosis (FC = 1.81, P = 0.008) and it was confirmed upregulated both in smoker early-stage cases (FC = 3.52, P = 0.024) and in nonsmoker early-stage cases (FC = 1.60, P = 0.025) compared with controls.
Conclusions:
We identified miR-151-3p as an early marker of HNC. This miRNA was the only upregulated in patients at early stages of the disease, independently of the smoking status.
Impact:
The prognosis for HNC is still poor. The discovery of a new diagnostic biomarker could lead to an earlier tumor discovery and therefore to an improvement in patient prognosis.
Data from Progress with Metabolomic Blood Tests for Gastrointestinal Cancer Diagnosis—An Assessment of Biomarker Translation
Authors: Savva Katerina-Vanessa , Das Bibek , Antonowicz Stefan , Hanna George B. , Peters Christopher J.
Published: May 2023

Abstract
There is an urgent need for cost-effective, non-invasive tools to detect early stages of gastrointestinal cancer (colorectal, gastric, and esophageal cancers). Despite many publications suggesting circulating metabolites acting as accurate cancer biomarkers, few have reached the clinic. In upper gastrointestinal cancer this is critically important, as there is no test to complement gold-standard endoscopic evaluation in patients with mild symptoms that do not meet referral criteria. Therefore, this study aimed to describe and solve this translational gap. Studies reporting diagnostic accuracy of metabolomic blood-based gastrointestinal cancer biomarkers from 2007 to 2020 were systematically reviewed and progress of each biomarker along the discovery–validation–adoption pathway was mapped. Successful biomarker translation was defined as a composite endpoint, including patent protection/FDA approval/recommendation in national guidelines. The review found 77 biomarker panels of gastrointestinal cancer, including 25 with an AUROC >0.9. All but one was stalled at the discovery phase, 9.09% were patented and none were clinically approved, confirming the extent of biomarker translational gap. In addition, there were numerous “re-discoveries,” including histidine, discovered in 7 colorectal studies. Finally, this study quantitatively supports the presence of a translational gap between discovery and clinical adoption, despite clear evidence of highly performing biomarkers with significant potential clinical value.
Data from Cost-Effectiveness of Colorectal Cancer Surveillance in Hodgkin Lymphoma Survivors Treated with Procarbazine and/or Infradiaphragmatic Radiotherapy
Authors: Ykema Berbel L.M. , Gini Andrea , Rigter Lisanne S. , Spaander Manon C.W. , Moons Leon M.G. , Bisseling Tanya M. , de Boer Jan Paul , Verbeek Wieke H.M. , Lugtenburg Pieternella J. , Janus Cecile P.M. , Petersen Eefke J. , Roesink Judith M. , van der Maazen Richard W.M. , Aleman Berthe M.P. , Meijer Gerrit A. , van Leeuwen Flora E. , Snaebjornsson Petur , Carvalho Beatriz , van Leerdam Monique E. , Lansdorp-Vogelaar Iris
Published: May 2023

AbstractBackground:
Hodgkin lymphoma survivors treated with infradiaphragmatic radiotherapy (IRT) and/or procarbazine have an increased risk of developing colorectal cancer. We investigated the cost-effectiveness of colorectal cancer surveillance in Dutch Hodgkin lymphoma survivors to determine the optimal surveillance strategy for different Hodgkin lymphoma subgroups.
Methods:
The Microsimulation Screening Analysis-Colon model was adjusted to reflect colorectal cancer and other-cause mortality risk in Hodgkin lymphoma survivors. Ninety colorectal cancer surveillance strategies were evaluated varying in starting and stopping age, interval, and modality [colonoscopy, fecal immunochemical test (FIT, OC-Sensor; cutoffs: 10/20/47 μg Hb/g feces), and multi-target stool DNA test (Cologuard)]. Analyses were also stratified per primary treatment (IRT and procarbazine or procarbazine without IRT). Colorectal cancer deaths averted (compared with no surveillance) and incremental cost-effectiveness ratios (ICER) were primary outcomes. The optimal surveillance strategy was identified assuming a willingness-to-pay threshold of €20,000 per life-years gained (LYG).
Results:
Overall, the optimal surveillance strategy was annual FIT (47 μg) from age 45 to 70 years, which might avert 70% of colorectal cancer deaths in Hodgkin lymphoma survivors (compared with no surveillance; ICER:€18,000/LYG). The optimal surveillance strategy in Hodgkin lymphoma survivors treated with procarbazine without IRT was biennial FIT (47 μg) from age 45 to 70 years (colorectal cancer mortality averted 56%; ICER:€15,000/LYG), and when treated with IRT and procarbazine, annual FIT (47 μg) surveillance from age 40 to 70 was most cost-effective (colorectal cancer mortality averted 75%; ICER:€13,000/LYG).
Conclusions:
Colorectal cancer surveillance in Hodgkin lymphoma survivors is cost-effective and should commence earlier than screening occurs in population screening programs. For all subgroups, FIT surveillance was the most cost-effective strategy.
Impact:
Colorectal cancer surveillance should be implemented in Hodgkin lymphoma survivors.
Polymorphisms in the Nonhomologous End-joining DNA Repair Pathway are Associated with HPV Integration in Cervical Dysplasia
Authors: Geris Jennifer M. , Amirian E. Susan , Marquez-Do Deborah A. , Guillaud Martial , Dillon Laura M. , Follen Michele , Scheurer Michael E.
Published: May 2023

Previous evidence indicates that human papillomavirus (HPV) integration status may be associated with cervical cancer development and progression. However, host genetic variation within genes that may play important roles in the viral integration process is understudied. The aim of this study was to examine the association between HPV16 and HPV18 viral integration status and SNPs in nonhomologous-end-joining (NHEJ) DNA repair pathway genes on cervical dysplasia. Women enrolled in two large trials of optical technologies for cervical cancer detection and positive for HPV16 or HPV18 were selected for HPV integration analysis and genotyping. Associations between SNPs and cytology (normal, low-grade, or high-grade lesions) were evaluated. Among women with cervical dysplasia, polytomous logistic regression models were used to evaluate the effect of each SNP on viral integration status. Of the 710 women evaluated [149 high-grade squamous intraepithelial lesion (HSIL), 251; low-grade squamous intraepithelial lesion (LSIL, 310 normal)], 395 (55.6%) were positive for HPV16 and 192 (27%) were positive for HPV18. Tag-SNPs in 13 DNA repair genes, including RAD50, WRN, and XRCC4, were significantly associated with cervical dysplasia. HPV16 integration status was differential across cervical cytology, but overall, most participants had a mix of both episomal and integrated HPV16. Four tag-SNPs in the XRCC4 gene were found to be significantly associated with HPV16 integration status. Our findings indicate that host genetic variation in NHEJ DNA repair pathway genes, specifically XRCC4, are significantly associated with HPV integration, and that these genes may play an important role in determining cervical cancer development and progression.

Prevention Relevance:

HPV integration in premalignant lesions and is thought to be an important driver of carcinogenesis. However, it is unclear what factors promote integration. The use of targeted genotyping among women presenting with cervical dysplasia has the potential to be an effective tool in assessing the likelihood of progression to cancer.
Supplementary Figure S5 from Safety and clinical response to combined immunotherapy with autologous iNKT cells and PD-1+CD8+ T cells in patients failing first-line chemotherapy in stage IV pancreatic cancer
Authors: Wang Jing , Cheng Xiaobo , Jin Yanling , Xia Bili , Qin Ran , Zhang Wei , Hu Huiliang , Mao Xiaoting , Zhou Liting , Yan Jia , Zhang Xiaoyan , Xu Jianqing
Published: May 2023

Proliferation curve of iNKT cells of P001 (A) and P002 (B) during expansion ex vivo. Curves representing iNKT cells expanded in later courses is shown in darker color.
Supplementary Figure S2 from Safety and clinical response to combined immunotherapy with autologous iNKT cells and PD-1+CD8+ T cells in patients failing first-line chemotherapy in stage IV pancreatic cancer
Authors: Wang Jing , Cheng Xiaobo , Jin Yanling , Xia Bili , Qin Ran , Zhang Wei , Hu Huiliang , Mao Xiaoting , Zhou Liting , Yan Jia , Zhang Xiaoyan , Xu Jianqing
Published: May 2023

Change of tumor markers recorded over time during treatment.
Supplementary Figure S1 from Safety and clinical response to combined immunotherapy with autologous iNKT cells and PD-1+CD8+ T cells in patients failing first-line chemotherapy in stage IV pancreatic cancer
Authors: Wang Jing , Cheng Xiaobo , Jin Yanling , Xia Bili , Qin Ran , Zhang Wei , Hu Huiliang , Mao Xiaoting , Zhou Liting , Yan Jia , Zhang Xiaoyan , Xu Jianqing
Published: May 2023

Expression of costimulatory receptor (A. ICOS and 4-1BB) and checkpoint ligands (B. CTLA-4 and PD-1) are assessed in expanded PD-1+CD8+ T cell products (n=5). Expression of CXCR4 and CXCR3 on PD-1+CD8+ T cells pre- and post-expansion are assessed by flow cytometry, and shown in C and D respectively (n=5).
Cabra marcado para morrer
Authors:   Universidade de São Paulo. Faculdade de Educação, Almeida Rogério de , Souza Christiane Pereira de ,   Universidade de São Paulo. Faculdade de Educação, Medeiros Kamilla ,   Universidade Federal do Rio de Janeiro
Published: May 2023

Este livro comemora os 90 anos de Eduardo Coutinho com artigos, depoimentos e entrevistas de pesquisadores e convidados que elaboram a grandeza de Cabra Marcado para Morrer e de seus protagonistas, dialogando com a História do Brasil e do Cinema Brasileiro. Com capítulos atravessados por reflexões, narrativas, contextos, diálogos, fotos e imagens, o livro conta também com prefácio de Pedro de Oliveira Coutinho e ilustrações de João Pinheiro.
Saneamento para estudantes e profissionais de saúde pública
Authors:   Universidade de São Paulo. Faculdade de Saúde Pública, Paganini Wanderley da Silva , Bocchiglieri Miriam Moreira ,   Universidade de São Paulo. Faculdade de Saúde Pública, Pitombo Leonardo Machado ,   Saneamento de Goiás S.A.
Published: May 2023

Importante vertente da formação do profissional em Saúde Pública está relacionada ao conhecimento da natureza do saneamento e sua finalidade, uma vez que conceitualmente, o saneamento ambiental integra um conjunto de ações que visam proporcionar níveis crescentes de salubridade. A ideia desta obra foi somar conhecimentos básicos a respeito do saneamento aos conhecimentos do senso comum, ou seja, introduzindo o leitor aos poucos no assunto, desmistificando a visão errônea de que o assunto é complexo e somente para técnicos do setor. É sob esse olhar que apresentamos este trabalho, e considerando nossas observações durante as aulas e palestras, e ainda, considerando a multidisciplinaridade e a dimensão coletiva da Saúde Pública, com inúmeras possibilidades de atuação destes profissionais, buscamos oferecer uma referência básica, apresentando conceitos fundamentais para que compreendam que saneamento é assunto de todos e para todos, principalmente quando está a serviço das populações vulneráveis, que em sua maioria, vivem em moradias subnormais, carentes de acesso ao saneamento.
Long‐Term High Level of Insulin Resistance Is Associated With an Increased Prevalence of Coronary Artery Calcification: The CARDIA Study
Authors: Ke Zezhi , Huang Rihua , Xu Xinghao , Liu Wenbin , Wang Suisui , Zhang Xu , Guo Ye , Zhuang Xiaodong , Zhen Liao
Published: May 2023

Background

Coronary artery calcification (CAC) is a crucial indicator of subclinical atherosclerotic cardiovascular disease. The relationship between long‐term insulin resistance (IR) trajectory and CAC has been explored in few studies. Therefore, this study aimed to investigate whether the long‐term IR time series of young adults are associated with the incidence of CAC in midlife.

Methods and Results

In a cohort study comprising 2777 participants from the CARDIA (Coronary Artery Risk Development in Young Adults) study, the homeostasis model assessment for IR was used to measure IR levels, and group‐based trajectory modeling was used to fit three 25‐year homeostasis model assessments for IR trajectories. Logistic regression was used to estimate the association between the 3 homeostasis model assessments for IR trajectories and CAC events at year 25. The results showed that among 2777 participants (mean age, 50.10±3.58 years; 56.2% women; 46.4% Black), there were 780 incident CAC events after a 25‐year follow‐up. After full adjustment, the prevalence of CAC was higher in the moderate‐ (odds ratio [OR], 1.40 [1.10–1.76]) and the high‐level homeostasis model assessments for IR trajectories (OR, 1.84 [1.21–2.78]) than in the low‐level trajectory. This association was observed in obese individuals despite the negative interaction between IR and different types of obesity (all
P
interactions >0.05).

Conclusions

Our study revealed that young adults with a higher level of IR were more likely to develop CAC in middle age. Furthermore, this association persisted in obese individuals. These findings highlight the importance of identifying subclinical cardiovascular risk factors and implementing primary prevention measures.
Diphilus’ Paralyomenos (P. Louvre 7733v, col. ii, 32-35): Reading the Evidence
Authors: Karamanou Ioanna
Published: May 2023

P. Louvre 7733v is the only source to attest a comedy by Diphilus entitled Paralyomenos and fr. 59 K.-A. from this play. This article ventures a cautious interrogation of the available—albeit limited and thus unexplored—evidence, with the purpose of extracting as much material as possible that could shed light on this play’s dramatic circumstances. It is argued that the present participle in the title is suggestive of a possibly critical situation (discharge from military service or physical disability) occurring within the course or shortly before the opening of the plot. Given parallel dramatic situations, it could reasonably be inferred that the title-character’s peculiar position may have got him involved in circumstances producing comic effect. Moreover, the restoration of fr. 59 proposed in this article may provide clues to a dramatic crisis. Overall, a close reading of the evidence in conjunction with comic practice could give scope for mapping the material concerning Diphilus’ Paralyomenos onto the dramatic contexts of fourth-century comedy.
An Aristotelian Account of Religious Music in Strabo, 10.3
Authors: Segev Mor
Published: May 2023

Strabo, in 10.3.7-23, presents an account of the music performed in initiation rites, according to which such music is used, naturally, to facilitate knowledge of divinity. I argue that, despite appearances, religious music, for Strabo, does not fulfill that function by reflecting the harmonious constitution of the cosmos—a Pythagorean-Platonic (and later, Stoic) idea that Strabo mentions but ultimately rejects. Instead, Strabo’s account is clearly influenced by Aristotelian theory, and it stresses the significance of the emotional effect (i.e., awe or astonishment) generated by religious music, which in turn is useful toward gaining knowledge of the gods, most probably because it motivates audiences to learn about them. Indeed, the affinity between Strabo’s text and Aristotle seems sufficient for Strabo’s 10.3.23, perhaps in addition to parts of 10.3.7 and 10.3.9, to count as Aristotelian ‘fragments.’
Epistemic Limitations & the Social-Guiding Function of Justice
Authors: Adams Matthew R.
Published: May 2023

The contemporary methodological debate about justice has centered around a dispute about the value of so-called ideal theory. I argue that justice performs a social-guiding function, which explains how people should respond to their limited and fallible abilities to realize justice institutionally. My argument helps to re-orientate the contemporary methodological debate. The obvious disagreement between many prominent supporters and skeptics of ideal theory obscures the fact that they are united by a false assumption: the practical value of justice exclusively consists of its institution-guiding function. To capture the overlooked social-guiding function, a richer normative theory of justice is required; I show how such a theory can be supplied by “ideal-transitional” principles.
Identity Politics and the Decolonization of the Western Mind: The Intellectual Resilience of Alain de Benoist and the Nouvelle Droite
Authors: Spektorowski Alberto
Published: May 2023

This article argues that parallel to and accompanying the populist backlash tormenting Western democratic societies, a new discourse has emerged to compete with liberal pluralism, progressive multiculturalism, and the ideology of universal human rights. It is a discourse running contrary to the positions expected of the exclusionist right. Rather than originating in a vulgar national-populist reaction against liberal democracy and minority rights, this competing perspective comes from an almost paradoxical synthesis of prefascist ideas developed in the early 20th century and current pro-diversity and anticolonialist theories.

In attempting to understand this perplexing ideological conjuncture, it can help to follow the ideological evolution of the French writer and ideologue of the French and European new right, Alain de Benoist. The ideas he developed in the 1980s and 1990s, and expanded in recent years, have contributed to synthesizing an ideological trend that is becoming central in the current debate on the populist backlash in Western democratic societies – right-wing postcolonialism. While de Benoist was not alone in this, he was one of the first to introduce and weaponize the discourse of the Weimar Conservative Revolution as a theory of emancipation for both Western repressed identities as for Third-World ones.
A new species of Tyrodes Raffray (Coleoptera: Staphylinidae: Pselaphinae) from China
Authors: ZHANG YONG-QIN , YIN ZI-WEI
Published: May 2023

A new species of the small pselaphine genus Tyrodes Raffray (Pselaphitae: Tyrini), T. tibialis sp. nov., is described and illustrated from Guangxi, southwestern China. This species can be separated from its congeners mainly by the aedeagal characters as well as by the modified sternite 2 (V), and presence of a preapical projection of the metatibiae.
The discovery of the subgenus Hysterobolus Viereck, 1913 (Hymenoptera, Braconidae, Brachistinae, Blacini, Blacus) in China, with description of nine new species
Authors: LU QIAN-YU , ACHTERBERG CORNELIS VAN , TANG PU , CHEN XUE-XIN
Published: May 2023

The subgenus Hysterobolus Viereck, 1913 (Hymenoptera, Braconidae, Blacus) is newly recorded from China. Nine new species are proposed, B. (H.) baishanzuensis sp. nov., B. (H.) flaviceps sp. nov., B. (H.) laculaticornis sp. nov., B. (H.) longiapicalis sp. nov., B. (H.) melanoapicalis sp. nov., B. (H.) niger sp. nov., B. (H.) variegatus sp. nov., B. (H.) xui sp. nov., B. (H.) yunnanensis sp. nov., and one species, B. (H.) chabarovi Belokobylskij, 1995, is newly recorded from China. An updated key to the currently known species of the subgenus Hysterobolus in China is provided.
Two new species of subtribe Monoctonina Mackauer from Europe (Hymenoptera, Braconidae, Aphidiinae)
Authors: TOMANOVIĆ ŽELJKO , PETROVIĆ ANDJELJKO , KOCIĆ KORANA , ČKRKIĆ JELISAVETA , CASIRAGHI ALICE , SAVAL JOSÉ M. MICHELENA
Published: May 2023

Falciconus hispanicus sp. n. and Monoctonus montenegrinus sp. n. are described as new members of the subtribe Monoctonina from Spain and from high mountain habitats of Montenegro, respectively. The main diagnostic characters of the newly described species and their host plant-host aphid associations are discussed.
A De-Noising Method for Microseismic Signal Based on the Synchrosqueezing Transform in the Time-Frequency Domain
Authors: Qin Xuan , Yu Zhichao , Yang Xueyan
Published: May 2023

The denoising for the microseismic signals in the strong background interferences during the microseismic monitoring of hydraulic fracturing is very important for events identification and first-arrival picking. As characteristics of microseismic signals are normally random, non-stationary,
and time-varying, a powerful tool for weak signal extraction of microseismic data is still a great challenge. In this study, a denoising method for microseismic signals is proposed based on the synchrosqueezing transform in the time-frequency domain. Firstly, the microseismic signals are denoised
by the adaptive threshold method in the time-frequency domain by the synchrosqueezing transform. Then, the frequency center of the effective signal is integrated and extracted in the time-frequency domain. At last, the weak signal is extracted by the reconstruction of synchrosqueezing transform.
The results from the synthesized non-stationary signal with different noise intensities and the real microseismic single of a track record show that this method has better anti-noise ability and higher signal extraction accuracy. Moreover, according to the processing and analysis of microseismic
data in field wells, it is proved that this denoising method has a good practical value and can extract the effective and high-precision signals in the strong noise background.
A Network Security Prediction Method Based on Attack Defense Tree
Authors: Li Junyi , Wu Yongdong , Li Yang , Zhang Ziwen , Fouad Hassan , Altameem Torki
Published: May 2023

Modern networks are vulnerable to coordinated assaults. To perform threat analysis on individual and combined attack behaviors, it is essential to establish a security situation analysis model based on offensive and defensive decisions. The standard attack tree model used in this study
ignores the impact of defenses, and the defensive tree model is not well scalable. Game theory is introduced into the attack tree model to describe specific network attack and defense event scenarios. First, analyze the logical relationship of different levels of attack behaviors in the network,
integrate the offensive and defensive trees corresponding to different levels of attack events, to obtain a complete network offensive and defensive behavior tree, and then build a network offensive and defensive behavior tree model. Second, the basic offensive and defensive behavior tree
extends from network offensive and defensive behavior, network detection equipment, and network defense measures. Propose an algorithm for the success rate of the attack target and calculate its attack probability. Based on these findings, we assess the potential for an attack and investigate
the current state of network defenses. An offensive and defensive behavior tree model based on the BGP (Border Gateway protoc01) attack tree was developed in order to test the viability and efficacy of the network offensive and defensive behavior tree model. The network attack and defensive
behavior tree model brought out in this study is capable of performing a wide range of calculations. The effect of defensive measures, as well as the ability to add and delete offensive and defensive behaviors at any node, has strong scalability and can provide a scientific basis for decision-making
for network managers and operators.
Mobile Multiple Sink Path Planning for Large-Scale Sensor Networks Based on Hyper-Heuristic Artificial Bee Colony Algorithm
Authors: Qian Lanmei , Zhang Haifei , Qiu Jianlin , Zhang Xudong , Fouad Hassan , Altameem Torki
Published: May 2023

Large-scale wireless sensor networks consists a terrific amount of nodes, a wide range of deployment, extended data transmission time, and large network energy consumption. To solve the above problems, a mobile multiple Sink path planning based on hyper-heuristic artificial bee colony
algorithm is proposed. The artificial bee colony algorithm is used as the high-level strategy. In view of the changes in the network operation process, namely the number of nodes and energy changes, the design of three stages of the artificial bee colony algorithm is used to choose and manipulate
the low-level heuristic operator. The selected lower layer operator set plans the path of each mobile sink nodes. Compared with other famous meta-heuristic algorithms, it is proved that the proposed hyper-heuristic algorithm is an effective, efficient and robust algorithm, which can effectively
solve the path planning problem in view of multiple sink nodes, reduce network delay and reduce network energy consumption.
Improving Healthcare Facility Safety with Electronic Monitoring by a Machine Learning Framework Based on the Internet of Things
Authors: Alalayah Khaled M. , Hazber Mohamed A. G. , Alreshidi Abdulrahman , Awaji Bakri , Olayah Fekry , Altamimi Mohammed
Published: May 2023

Hacks, unauthorised access, and other problems have increased the risk to the healthcare system dependent on data analytics in recent years. When a system is kept in its factory settings, it provides an easier target for hackers who wish to get access to the server and steal data. In order to protect the privacy of patients, we use an innovative encryption approach called the Whale-based Random Forest (WbRF) Scheme in this research. Furthermore, ciphertext is made by layering micro-electronic sensors and employing Identity-based Encryption (IBE) on plaintext. The purpose of this surveillance is to ensure the model’s continued health while keeping a vigilant eye out for threats. Therefore the framework is programmed into the Python tool, and the system is trained on more than 200 patient datasets. Medical records for patients can be encrypted and stored safely in the cloud using nano-electronic jargon, in the end. The generated model is subjected to various attacks in order to determine how secure and effective it really is. Energy consumption, execution time, encryption time, latency, accuracy, and decryption time are compared between the created framework and conventional methods.
Pleural Effusion and Malnutrition Are Associated With Worse Early Outcomes After Liver Transplant
Authors: Clouse Jared W. , Mangus Richard S. , Vega Carlos A. , Cabrales Arianna E. , Bush Weston J. , Clouse Isaac T. , Ekser Burcin , Mihaylov Plamen , Kubal Chandrashekhar A.
Published: May 2023

Introduction

Pulmonary complications after liver transplantation (LT) have previously been associated with longer hospital stays and ventilator time, and higher mortality. This study reports the outcomes for a specific pulmonary complication, pleural effusion, in LT recipients.

Methods

Records from a single transplant center were analyzed retrospectively for all adult LT patients. Patients with documented pleural effusion by radiographic imaging within 30 days pre- or post-transplant were considered as cases. Outcomes included length of hospital stay, discharge disposition, hospital readmission, discharge with home oxygen, and 1-year survival.

Results

During the 4-year study period, 512 LTs were performed, with 107 patients (21%) developing a peri-transplant pleural effusion. In total, 49 patients (10%) had a pre-transplant effusion, 91 (18%) had a post-transplant effusion, and 32 (6%) had both. Characteristics associated with the presence of any pleural effusion included an increasing model for end-stage liver disease score, re-transplantation, diagnosis of alcoholic liver disease, low protein levels, and sarcopenia. Effusion patients had longer hospital stays (17 vs 9 days, P < .001) and higher likelihood of discharge to a care facility (48% vs 21%, P < .001). Ninety-day readmission occurred in 69% of effusion patients (vs 44%, P < .001). One-year patient survival with any effusion was 86% (vs 94%, P < .01).

Conclusions

Overall, 21% of recipients developed a clinically significant peri-transplant pleural effusion. Pleural effusion was associated with worse outcomes for all clinical measures. Risk factors for the development of pleural effusion included higher MELD score (>20), re-transplantation, alcoholic liver disease, and poor nutrition status, including poor muscle mass.
The struggle to find theory
Authors: Driessen Molly C
Published: May 2023

The purpose of this brief note is to critically reflect on the unresolvedness of the multiple debates within the field of social work, using both scholar and practitioner perspectives. These debates include theory’s relationship to research and practice, the micro-mezzo-macro practice divides, and broader questions of the profession’s identity.
Understanding Female Jihadism in Bangladesh: New Trends in “New Normal”?
Authors: Sharma Shudipta
Published: May 2023

This study aims to understand Bangladeshi female jihadists’ evolving socio-demographic backgrounds, organizational roles, and the driving factors that radicalize them. It is found that besides homemakers and students, female jihadists, who are mainly young, come from various professions, including education, health, business, law, and private jobs. The results indicate that women in higher socioeconomic status, who endorse violent tactics and militant objectives, may be more inclined to participate in jihadism actively. During the COVID-19 pandemic, instead of carrying out violent attacks, they use social media to spread their extremist ideologies, recruit new members, and raise funds. The results show that the Internet played a significant role in the radicalization of women during the pandemic, while family and friends played the leading role in the past.
Are employer-dismissed older workers adequately compensated? Comparison of Australian and UK age discrimination and dismissal cases
Authors: Gardiner Elliroma , Debrulle Jonas
Published: May 2023

This paper focuses on the legal remedies for age discrimination and dismissal of older workers, identifying the factors that courts and tribunals in Australia and the United Kingdom (UK) consider when calculating compensation for two forms of damages: injury to feelings and future losses. A secondary aim is to determine whether these factors adequately consider the unique workforce participation challenges faced by older workers in both countries. Considering the similarities between Australian and UK age discrimination law and given that the latter jurisdiction has had considerably more successful cases than the former, this study adopts a comparative approach and draws on UK cases to inform the development of Australian age discrimination law. Analysis of all successful Australian and a selection of successful UK age discrimination and dismissal cases spanning from 2017 to 2020 suggests that Australian law might be strengthened by: adopting a scale of awards similar to the guidelines established in Vento v Chief Constable of West Yorkshire Police [2002] EWCA Civ 1871 (‘ Vento’) for recognising and awarding injury to feelings; and by more readily awarding future losses, particularly for claimants who plan to work or who are already working past retirement age.
Posttraumatic Growth Inventory–Expanded: Factor Structure, Test-Retest Reliability, and Validity in Trauma-Exposed and Bereaved Adults
Authors: Lee Hwa Jung , Lee Dong Hun , Lee Deok Hee , Kim Ji Yun
Published: May 2023

Posttraumatic growth (PTG) is a positive psychological change experienced after trauma and it has gained global recognition in recent years. The present study aimed to validate a South Korean version of the Posttraumatic Growth Inventory–Expanded (K-PTGI-X) for use with trauma-exposed and bereaved samples. A national sample comprising South Korean adults was used for the analysis. As a result, the 4-factor bi-factor model was best supported in both the trauma and bereaved groups in terms of personal strength, new possibilities, spiritual–existential change, and being able to relate to others. Additionally, the K-PTGI-X showed satisfying reliability, concurrent validity, and discriminant validity. Lastly, regarding the group differences, women showed higher rates of PTG than men and the bereaved group exhibited higher spiritual and existential growth in the PTG than the trauma group. Given these results, implications for adaptation in various fields when assessing and encouraging PTG in practical settings are discussed.
Dialectical Core Schemas Mediate the Relationships Between Dissociative Experiences and Symptomatology in a Community Sample
Authors: Faustino Bruno , Pilkington Pamela , Pascoal Patrícia M.
Published: May 2023

Background

Maladaptive cognitions about the self and others are associated with a wide array of dysfunctional responses and psychopathological symptoms in non-clinical and clinical samples. Dissociative experiences (e.g., depersonalization and derealization) as a coping response to stressful situations lie on a continuum from healthy to unhealthy but are generally elevated in individuals experiencing mental illness. However, the extent to which Dialectical Core Schemas explain the relationship between dissociative experiences and symptomatology is unclear. Therefore, this study aimed to investigate the mediating role of Dialectical Core Schemas on the relationship between dissociative experiences and symptomatology.

Methods

A community sample of 179 participants were recruited ( M age = 21.2 years, SD = 8.2). Data were gathered through self-report questionnaires using a cross-sectional design.

Results

Maladaptive core schemas about self and others correlated positively with all dissociative experiences (e.g., depersonalization/derealization, amnesia), while adaptive core schemas about the self correlated negatively with depersonalization/derealization and distractibility. Maladaptive core schemas mediated the relationship between dissociative experiences and symptomatology.

Conclusions

The relationships between dissociative experiences and symptomatology are bi-directional. Exploring the mediating factors may help clinicians and researchers better understand how to enhance case conceptualization and clinical decision-making.
Enhanced water permeability of hollow fiber composite reverse osmosis membrane using porous α-cellulose/polysulfone hollow fiber membrane as the substrate
Authors: Li Hongbin , Fan Mengjie , Li Linmao , Ma Sisi , Shi Wenying , Liu Jie
Published: May 2023

The hollow fiber composite (HFC) reverse osmosis (RO) membrane with a special self-supporting structure has attracted a great deal of attention in the fields of separation and purification. However, low permeability is an urgent problem restricting its wide application. A porous polysulfone (PSF) hollow fiber support membrane was fabricated through the dry–wet spinning technique and hydrophilic α-cellulose © powder was incorporated in the PSF membrane matrix to improve the membrane’s water permeability. The HFC RO membrane was prepared via the interfacial polymerization process on the inner surface of the C/PSF support membrane. The membrane morphology and surface hydrophilicity were evaluated through scanning electron microscopy observation and dynamic water contact angle (WCA) measurement. The effects of α-cellulose incorporation on the separation performance of PSF hollow fiber membranes and HFC RO membranes were investigated. The results showed that the surface hydrophilicity and water permeability of the PSF membrane were significantly improved after the introduction of α-cellulose. The WCA of the modified PSF support membrane decreased from 84.6° for the neat PSF membrane to 70.25°, and the pure water flux can reach a maximum value of 102.1 L/(m2 · h) (0.1 Mpa), which was 1.3 times that of the pristine membrane. The HFC RO membrane using the hydrophilic modified PSF membrane as the substrate exhibited an enhanced water flux of 15.6 L/(m2 · h) and, meanwhile, the membrane salt rejection remained above 97.6% (1.0 wt% NaCl aqueous solution, 0.7 Mpa). The HFC RO membrane showed extremely high rejection rates (99%) for different dyes (congo red and methylene blue). No obvious performance deterioration was observed for the HFC RO membrane during continuous vacuum membrane distillation (VMD) experiments for 60 h.
Intersex equality, diversity and inclusion and social policy: Silences, absences, and erasures in Ireland and the UK
Authors: Monro Surya , Wall Sean Saifa , Wood Kate
Published: May 2023

Intersex people suffer human rights abuses and harms because of non-consensual early medical interventions. They have historically been rendered outside of welfare regimes and equality, diversity and inclusion policies, or forcibly subsumed within sex-binaried institutions. This article draws on critical intersex studies to interrogate the policy silences and collusions that have taken place regarding intersex people's suffering. Using Ireland and England as case studies, we show that current formations of equality and diversity policies are inadequate in relation to intersex issues. Analysis of policy documents from Ireland and the UK using Bacchi's method reveals the erasure and/or marginalisation of intersex people, despite some stated commitments to gender and sexual equality. We conclude that there is a pressing need for social policy work around intersex issues and for reform to support intersex people's equality, diversity and inclusion.
Weed-fed Pigs: Food Sovereignty in the Blind Spot
Authors: Wu Xu
Published: May 2023

Implicit everyday forms of food sovereignty can be explored to reveal the diversity of the movement. For example, the ways in which elderly villagers raise pigs on weeds in central China share some features with the “quiet food sovereignty” of Russia. Small-scale pig rearing is largely invisible to outsiders, so identifying it relies heavily on weeds as indicators. Bounded by age in rural southwest Hubei, the small space of raising weed-fed pigs emerged in a blind spot between discourses on modern technological agriculture and concerns for food safety. In the 1990s, elderly villagers continued feeding pigs on local plants instead of using industrial fodder in order to retain the authentic taste of pork, which continues to have social value. The practice took on added significance as a form of self-protection from food-safety issues in the 2000s. It provides a moral buffer for elderly villagers sandwiched between the conflicting values of modern scientific and technological farming supported by the state policy of “Increasing Agricultural Prosperity with Modern Sci-tech” and emerging organic or green food movements motivated by urban people's desire for safe foods and state agenda on developing rural tourism. Despite the ecological, material, health, and social benefits of operating in this small space, their implicit food sovereignty goes unnoticed. Because raising weed-fed pigs functions invisibly, it remains in the blind spot of mass food discourses in China.
‘Which Part of Your Work is IR?’ on Western Dominance and the Discipline of International Relations in Indonesia
Authors: Umar Ahmad Rizky Mardhatillah
Published: May 2023

This article aims to analyse the foundations of Western dominance in the discipline of International Relations (IR) in Indonesia. Drawing on a contextualized autoethnographic reflection of learning and researching IR in Indonesia during my undergraduate studies between 2008 and 2013, I argue that Western dominance in Indonesian IR discipline is not simply characterized by imposition of a certain academic tradition from the West but also reproduced in everyday academic discourse and naturalized through institutional practices of power. Drawing on my autoethnographic reflections, Western dominance has been maintained and naturalized through everyday exclusionary practices in IR discipline. I encountered this exclusionary practice through a gatekeeping question that was often asked during my time as an undergraduate student and researcher in Indonesia: ‘which part of your work is IR?’. This gatekeeping practice is rooted in the larger history of bureaucratization and state co-optation of Indonesian academic community, which is still perpetuated by the government. Nevertheless, this Western epistemic dominance has been resisted through non-academic spaces. Through this contextualized autoethnographic reflections, I offer some rethinking of Global IR project by highlighting internal hierarchy and Western dominance in the discipline of International Relations, as well as resistance against it by non-academic communities.