bluuebunny/crossref_metadata_2025 huggingface dataset:
Mind the gap: trajectory of cognitive development in young individuals with sickle cell disease: a cross-sectional study
Authors: Koelbel Melanie , Hamdule Shifa , Kirkham Fenella J. , Stotesbury Hanne , Hood Anna Marie , Dimitriou Dagmara
Published: July 2023

Study objectives

Compared to typically developing children and young adults (CYA-TD), those living with Sickle Cell Disease (CYA-SCD) experience more cognitive difficulties, particularly with executive function. Few studies have examined the relative importance of silent cerebral infarction (SCI), haemoglobin and arterial oxygen content on age-related cognitive changes using cross-sectional or longitudinal (developmental trajectory) data. This study presents cohort data from a single timepoint to inform studies with multiple timepoints.

Methods

We compared cross-sectional raw and scaled scores as age-related changes in cognition (trajectories) in CYA-SCD and age-and ethnicity-matched CYA-TD. We also compared cross-sectional age-related changes in cognition (trajectories) in CYA-SCD with and without SCI to CYA-TD. General cognitive abilities were assessed using Wechsler Intelligence Scales, including the Verbal Comprehension Index (VCI) and Perceptual Reasoning Index (PRI) underpinning IQ. Executive function was evaluated using the Delis-Kaplan Executive Function System (D-KEFS) Tower subtest and the Behaviour Rating Inventory of Executive Function (BRIEF) questionnaire. SCI were identified from contemporaneous 3 T MRI; participants with overt stroke were excluded. Recent haemoglobin was available and oxygen saturation (SpO2) was measured on the day of the MRI.

Results

Data were available for 120 CYA-SCD [62 male; age = 16.78 ± 4.79 years; 42 (35%) with SCI] and 53 CYA-TD (23 male; age = 17.36 ± 5.16). Compared with CYA-TD, CYA-SCD experienced a delayed onset in VCI and slower rate of development for BRIEF Global Executive Composite, Metacognition Index (MI), and Behaviour Regulation Index. The rate of executive function development for the BRIEF MI differed significantly between CYA-TD and CYA-SCD, with those with SCI showing a 26% delay compared with CYA-TD. For CYA-SCD with SCI, arterial oxygen content explained 22% of the variance in VCI and 37% in PRI, while haemoglobin explained 29% of the variance in PRI.

Conclusion

Age-related cognitive trajectories of CYA-SCD may not be impaired but may progress more slowly. Longitudinal studies are required, using tests unaffected by practice. In addition to initiation of medical treatment, including measures to improve arterial oxygen content, early cognitive intervention, educational support, and delivery of extracurricular activities could support cognitive development for CYA-SCD.
Burden and attributable risk factors of ischemic stroke in China from 1990 to 2019: an analysis from the Global Burden of Disease Study 2019
Authors: Ye Yang , Zhu Yu-Tian , Zhang Jia-Cheng , Zhang Hao-Lin , Fan Rui-Wen , Jin Yu-Xin , Hu Hang-Qi , Xin Xi-Yan , Li Dong
Published: July 2023

Background

The epidemiologic characteristics and attributable risk factors of ischemic stroke in China have changed over the past three decades. An up-to-date analysis on deaths, disability-adjusted life-years (DALYs), prevalence, incidence, and attributable risk factors of ischemic stroke for China is needed. This study aims to provide a comprehensive analysis of burden and attributable risk factors of ischemic stroke at national level in China by sex from 1990 to 2019.

Methods

This is a secondary analysis of the Global Burden of Disease (GBD) study 2019. All data used in this study was derived from the 2019 GBD study. Deaths, DALYs, prevalence, incidence, and attributable risk factors of ischemic stroke in China by sex from 1990 to 2019 were analyzed.

Results

From 1990 to 2019, the age-standardized deaths rate decreased by 3.3%, age-standardized DALYs rate decreased by 4%, age-standardized prevalence rate increased by 33.5%, and age-standardized incidence rate of ischemic stroke in China increased by 34.7%. In 2019, ambient particulate matter pollution became an important risk factor, whereas household air pollution from solid fuels was no longer a major risk factor for ischemic stroke in China. Burden of ischemic stroke was higher in China compared to other regions. Ambient particulate matter pollution among men, and diet high in sodium, smoking, household air pollution from solid fuels among women account for the increased deaths/DALYs due to ischemic stroke in China.

Conclusion

Our study revealed that great changes have occurred in burden and attributable risk factors of ischemic stroke in China in the past three decades. Distinct sex-specific differences are observed in burden and attributable risk factors.
Maternal vitamin D status and risk of childhood overweight at 5 years of age in two Nordic cohort studies
Authors: Amberntsson Anna , Bärebring Linnea , Winkvist Anna , Lissner Lauren , Meltzer Helle Margrete , Brantsæter Anne Lise , Papadopoulou Eleni , Augustin Hanna
Published: July 2023

Introduction

Maternal vitamin D status during pregnancy has been suggested to have a role in childhood adiposity development, but results are conflicting. Our aims were to investigate [1] the relationships between maternal 25-hydroxyvitamin D (25OHD) during pregnancy and the child’s body mass index (BMI) and risk of overweight at 5 years of age, and [2] maternal pre-pregnancy BMI as effect modifier for these associations.

Methods

Data sources included a subsample from the Norwegian Mother, Father and Child Cohort Study (MoBa sub-cohort; N = 2,744) and the Swedish GraviD cohort study (N = 891). Maternal 25OHD was analyzed in gestational week 18 in the MoBa sub-cohort and week 10 in the GraviD cohort. In the MoBa sub-cohort, parents reported their child’s documented measures of weight and length or height from the health card at routine check-up. In the GraviD cohort, this information was collected directly from medical records. Childhood overweight (including obesity) was identified using the International Obesity Task Force cut-offs. Linear and logistic regression models were used to investigate the association between maternal 25OHD and child’s BMI and risk of overweight at 5 years of age in each cohort separately, and in a pooled dataset.

Results

In the pooled analysis, maternal 25OHD <30 nmol/L was associated with lower BMI in children at 5 years of age, but not with risk of overweight. Interaction analysis showed that the association was predominant among children of mothers with pre-pregnancy BMI ≥25 kg/m2.

Conclusion

Low maternal vitamin D status, particularly in mothers with overweight or obesity, predicted lower BMI in their five-year-old children. However, there was no evidence of an effect on overweight in these children.
Evaluation of oncofertility care in childhood cancer patients: the EU-Horizon 2020 twinning project TREL initiative
Authors: Stukaite-Ruibiene Egle , van der Perk M. E. Madeleine , Vaitkeviciene Goda Elizabeta , Bos Annelies M. E. , Bumbuliene Zana , van den Heuvel-Eibrink Marry M. , Rascon Jelena
Published: July 2023

Background

The 5-year survival rate of childhood cancer exceeds 80%, however, many survivors develop late effects including infertility. The aim of this study was to evaluate the current status of oncofertility care at Vilnius University Hospital Santaros Klinikos (VULSK) within the framework of the EU-Horizon 2020 TREL project.

Methods

All parents or patients aged 12–17.9 years treated from July 1, 2021 until July 1, 2022 were invited to complete an oncofertility-care-evaluation questionnaire. After completing the questionnaire, patients were triaged to low-risk (LR) or high-risk (HR) of gonadal damage using a risk stratification tool (triage). Data was assessed using descriptive statistics.

Results

Questionnaires were completed by 48 parents and 13 children triaged as 36 (59%) LR and 25 (41%) HR patients. Most HR respondents (21/25, 84%) were not counseled by a fertility specialist. Six boys (4 HR, 2 LR) were counseled, none of the girls was counseled. Three HR boys underwent sperm cryopreservation. Only 17 (27.9%, 9 HR, 8 LR) respondents correctly estimated their risk. All counseled boys (n = 6) agreed the risk for fertility impairment had been mentioned as compared to 49.1% (n = 27) of uncounseled. All counseled respondents agreed they knew enough about fertility (vs. 42%).

Conclusions

Respondents counseled by a fertility specialist were provided more information on fertility than uncounseled. HR patients were not sufficiently counseled by a fertility specialist. Based on the current experience oncofertility care at VULSK will be improved.
The cost-effectiveness of cemiplimab plus chemotherapy as the first-line treatment for advanced non-small cell lung cancer
Authors: Lu Tingting , Huang Yufan , Cai Zhongjie , Lin Wangchun , Chen Xiaoxiao , Chen Ruijia , Hu Yingying
Published: July 2023

Background: The EMPOWER-LUNG 3 clinical trial has shown that cemiplimab plus chemotherapy (CCT) significantly extended overall survival (OS) and progression-free survival (PFS) for patients with advanced non-small cell cancer (NSCLC) compared to placebo plus chemotherapy (PCT). However, the cost-effectiveness of this new treatment option remains unknown. Thus, we evaluated the cost-effectiveness of CCT versus (vs.) PCT as the first-line treatment for patients with advanced NSCLC from the perspective of the Chinese healthcare system.

Methods: We constructed a Markov model to evaluate the cost-effectiveness of CCT as the first-line treatment for patients with advanced NSCLC. The transition probabilities were extracted from the survival data of the EMPOWER-LUNG 3 trial. The drugs’ costs were referred from national tender prices, while other model input parameters were derived from the EMPOWER-LUNG 3 trial and published literature. The outcome parameters mainly included quality-adjusted life years (QALYs) and incremental cost-effectiveness ratios (ICERs). One-way sensitivity analysis and probabilistic sensitivity analysis were performed to evaluate the robustness of the model outcomes.

Results: Compared to PCT, in the CCT regimen, an additional $79,667 was spent in terms of the total cost and with an additional 0.31 QALYs, resulting in an ICER value of $253,148/QALY. Sensitivity analysis indicated that the hazard ratio (HR) of OS, the cost of cemiplimab (100 mg), and the HR of PFS, all significantly impacted the model’s results. The probability of CCT (vs. PCT) being cost-effective was 0% at a willingness-to-pay threshold of $38,201/QALYs in China. The scenario analysis showed that when the price of cemiplimab was reduced to less than $184.09/100 mg, the CCT regimen could be considered cost-effective as the first-line treatment for patients with advanced NSCLC compared to the PCT.

Conclusion: In China, the CCT was not cost-effective as the first-line treatment for patients with advanced NSCLC.
In vitro and in vivo effects of Pelargonium sidoides DC. root extract EPs® 7630 and selected constituents against SARS-CoV-2 B.1, Delta AY.4/AY.117 and Omicron BA.2
Authors: Emanuel Jackson , Papies Jan , Galander Celine , Adler Julia M. , Heinemann Nicolas , Eschke Kathrin , Merz Sophie , Pischon Hannah , Rose Ruben , Krumbholz Andi , Kulić Žarko , Lehner Martin D. , Trimpert Jakob , Müller Marcel A.
Published: July 2023

The occurrence of immune-evasive SARS-CoV-2 strains emphasizes the importance to search for broad-acting antiviral compounds. Our previous in vitro study showed that Pelargonium sidoides DC. root extract EPs® 7630 has combined antiviral and immunomodulatory properties in SARS-CoV-2-infected human lung cells. Here we assessed in vivo effects of EPs® 7630 in SARS-CoV-2-infected hamsters, and investigated properties of EPs® 7630 and its functionally relevant constituents in context of phenotypically distinct SARS-CoV-2 variants. We show that EPs® 7630 reduced viral load early in the course of infection and displayed significant immunomodulatory properties positively modulating disease progression in hamsters. In addition, we find that EPs® 7630 differentially inhibits SARS-CoV-2 variants in nasal and bronchial human airway epithelial cells. Antiviral effects were more pronounced against Omicron BA.2 compared to B.1 and Delta, the latter two preferring TMPRSS2-mediated fusion with the plasma membrane for cell entry instead of receptor-mediated low pH-dependent endocytosis. By using SARS-CoV-2 Spike VSV-based pseudo particles (VSVpp), we confirm higher EPs® 7630 activity against Omicron Spike-VSVpp, which seems independent of the serine protease TMPRSS2, suggesting that EPs® 7630 targets endosomal entry. We identify at least two molecular constituents of EPs® 7630, i.e., (−)-epigallocatechin and taxifolin with antiviral effects on SARS-CoV-2 replication and cell entry. In summary, our study shows that EPs® 7630 ameliorates disease outcome in SARS-CoV-2-infected hamsters and has enhanced activity against Omicron, apparently by limiting late endosomal SARS-CoV-2 entry.
Directed graph mapping shows rotors maintain non-terminating and focal sources maintain self-terminating Torsade de Pointes in canine model
Authors: Van Den Abeele Robin , Hendrickx Sander , Van Nieuwenhuyse Enid , Dunnink Albert , Panfilov Alexander V. , Vos Marc A. , Wülfers Eike M. , Vandersickel Nele
Published: July 2023

Torsade de Pointes is a polymorphic ventricular tachycardia which is as yet incompletely understood. While the onset of a TdP episode is generally accepted to be caused by triggered activity, the mechanisms for the perpetuation is still under debate. In this study, we analysed data from 54 TdP episodes divided over 5 dogs (4 female, 1 male) with chronic atrioventricular block. Previous research on this dataset showed both reentry and triggered activity to perpetuate the arrhythmia. 13 of those TdP episodes showed reentry as part of the driving mechanism of perpetuating the episode. The remaining 41 episodes were purely ectopic. Reentry was the main mechanism in long-lasting episodes (>14 beats), while focal sources were responsible for maintaining shorter episodes. Building on these results, we re-analysed the data using directed graph mapping This program uses principles from network theory and a combination of positional data and local activation times to identify reentry loops and focal sources within the data. The results of this study are twofold. First, concerning reentry loops, we found that on average non-terminating (NT) episodes (≥10 s) show significantly more simultaneous reentry loops than self-terminating (ST) TdP (<10 s). Non-terminating episodes have on average 2.72 ± 1.48 simultaneous loops, compared to an average of 1.33 ± 0.66 for self-terminating episodes. In addition, each NT episode showed a presence of (bi-)ventricular loops between 10.10% and 69.62% of their total reentry duration. Compared to the ST episodes, only 1 in 4 episodes (25%) showed (bi-)ventricular reentry, lasting only 7.12% of its total reentry duration. This suggests that while focal beats trigger TdP, macro-reentry and multiple simultaneous localized reentries are the major drivers of long-lasting episodes. Second, using heatmaps, we found focal sources to occur in preferred locations, instead of being distributed randomly. This may have implications on treatment if such focal origins can be disabled reliably.
Transcriptome analysis of mRNAs, lncRNAs, and miRNAs in the skeletal muscle of Tibetan chickens at different developmental stages
Authors: Li Jie , Chen Chuwen , Zhao Ruipeng , Wu Jinbo , Li Zhixiong
Published: July 2023

Introduction: As a valuable genetic resource, native birds can contribute to the sustainable development of animal production. Tibetan chickens, known for their special flavor, are one of the important local poultry breeds in the Qinghai–Tibet Plateau. However, Tibetan chickens have a slow growth rate and poor carcass traits compared with broilers. Although most of the research on Tibetan chickens focused on their hypoxic adaptation, there were fewer studies related to skeletal muscle development.

Methods: Here, we performed the transcriptional sequencing of leg muscles from Tibetan chicken embryos at E (embryonic)10, E14, and E18.

Results: In total, 1,600, 4,610, and 2,166 DE (differentially expressed) mRNAs, 210, 573, and 234 DE lncRNAs (long non-coding RNAs), and 52, 137, and 33 DE miRNAs (microRNAs) were detected between E10 and E14, E10 and E18, and E14 and E18, respectively. Functional prediction showed several DE mRNAs and the target mRNAs of DE lncRNAs and DE miRNAs were significantly enriched in sarcomere organization, actin cytoskeleton organization, myofibril, muscle fiber development, and other terms and pathways related to muscle growth and development. Finally, a lncRNA–miRNA–mRNA ceRNA (competing endogenous RNA) network associated with muscle growth and development, which contained 6 DE lncRNAs, 13 DE miRNAs, and 50 DE mRNAs, was constructed based on the screened DE RNAs by Gene Ontology (GO) enrichment. These DE RNAs may play a critical regulatory role in the skeletal muscle development of chickens.

Discussion: The results provide a genomic resource for mRNAs, lncRNAs, and miRNAs potentially involved in the skeletal muscle development of chickens, which lay the foundation for further studies of the molecular mechanisms underlying skeletal muscle growth and development in Tibetan chickens.
Neural pathways of attitudes toward foreign languages predict academic performance
Authors: Lu Di , Wang Xin , Wei Yaozhen , Cui Yue , Wang Yapeng
Published: July 2023

Learning attitude is thought to impact students’ academic achievement and success, but the underlying neurocognitive mechanisms of learning attitudes remain unclear. The purpose of the present study was to investigate the neural markers linked to attitudes toward foreign languages and how they contribute to foreign-language performance. Forty-one Chinese speakers who hold differentiated foreign language (English) attitudes were asked to complete an English semantic judgment task during a functional magnetic resonance imaging (fMRI) experiment. Multimethod brain imaging analyses showed that, compared with the positive attitude group (PAG), the negative attitude group (NAG) showed increased brain activation in the left STG and functional connectivity between the left STG and the right precentral gyrus (PCG), as well as changed functional segregation and integration of brain networks under the English reading task, after controlling for English reading scores. Mediation analysis further revealed that left STG activity and STG-PCG connectivity mediated the relationships between English attitudes and English reading performance. Taken together, these findings suggest that objective neural markers related to subjective foreign language attitudes (FLAs) exist and that attitude-related neural pathways play important roles in determining students’ academic performance. Our findings provide new insights into the neurobiological mechanisms by which attitudes regulate academic performance.
Resilience mediates the effect of peer victimization on quality of life in Chongqing adolescents: from a perspective of positive childhood experiences
Authors: Deng Liya , Liu Yang , Wang Hong , Yu Junjie , Liao Liping
Published: July 2023

Background

Peer victimization is a harmful experience that contributed to one's psychological problems, physical health deterioration, and so on. Quality of life (QoL) is an important indicator of adolescent health assessment. To identify potential pathways of positive experiences in preventing peer victimization's detrimental effects and then provide intervention ideas for adolescent health, this study was conducted to examine the relationship between peer victimization and QoL in Chongqing adolescents and discover whether resilience plays a mediating role and positive childhood experiences (PCEs) act as a moderating role in the relationship.

Methods

Data were the first follow-up of a cohort study conducted in four complete middle schools in two districts of Chongqing, China. Self-designed peer victimization items, the Connor–Davidson Resilience Scale, the Adolescent Quality of Life Scale, and the Benevolent Childhood Experiences Scale were used. We investigated the differences and correlations in peer victimization, QoL, and resilience between the two PCEs groups. Mplus version 8.3 was used to analyze the mediating role of resilience and the moderating role of PCEs in peer victimization and QoL.

Results

Peer victimization, resilience, and QoL differed between the two PCEs groups (P < 0.001). Peer victimization negatively correlated with QoL and resilience, while resilience positively correlated with QoL (P < 0.001). In the models with total QOL as the dependent variable, the indirect effect was −0.431 (8.08% of the total effect) in the low-PCEs group vs. −2.077 (41.97% of the total effect) in the high-PCEs group. In the models with four dimensions of QOL as the dependent variable, the indirect effects ranged from −0.054 to −0.180 (6.07–12.95% of the total effects) in the low-PCEs group and from 0.295 to −0.823 in the high-PCEs group (35.89–68.76% of the total effects). Both total and indirect effects were significant (P < 0.05). In addition, the differences in indirect effects were significant between the two PCEs groups (P < 0.05), while differences in total and direct effects were almost not apparent.

Conclusion

Resilience partially mediated the effect of peer victimization on QoL in Chongqing adolescents, and PCEs moderated this mediation. Schools, families, and society should focus on resilience intervention and prioritize the enhancement of PCEs for improving adolescent QoL.
Combined exposure to PM2.5 and PM10 in reductions of physiological development among preterm birth: a retrospective study from 2014 to 2017 in China
Authors: Hu Bo , Tang Jie , Xu Guangtao , Shao Dongliang , Huang Huafei , Li Jintong , Chen Huan , Chen Jie , Zhu Liangjin , Chen Shipiao , Shen Bin , Jin Limin , Xu Long
Published: July 2023

Background

Preterm birth (PTB) has been linked with ambient particulate matter (PM) exposure. However, data are limited between physiological development of PTB and PM exposure.

Methods

Trimester and season-specific PM exposure including PM2.5 and PM10 was collected from Jiaxing between January 2014 and December 2017. Information about parents and 3,054 PTB (gestational age < 37 weeks) outcomes such as weight (g), head circumference (cm), chest circumference (cm), height (cm) and Apgar 5 score were obtained from birth records. We used generalized linear models to assess the relationship between PTB physiological developmental indices and PM2.5, PM10 and their combined exposures. A binary logistic regression model was performed to assess the association between exposures and low birth weight (LBW, < 2,500 g).

Results

Results showed that there were 75.5% of low birth weight (LBW) infants in PTB. Decreased PM2.5 and PM10 levels were found in Jiaxing from 2014 to 2017, with a higher PM10 level than PM2.5 each year. During the entire pregnancy, the highest median concentration of PM2.5 and PM10 was in winter (61.65 ± 0.24 vs. 91.65 ± 0.29 μg/m3) followed by autumn, spring and summer, with statistical differences in trimester-specific stages. After adjusting for several potential factors, we found a 10 μg/m3 increase in joint exposure of PM2.5 and PM10 during the entire pregnancy associated with reduced 0.02 week (95%CI: −0.05, −0.01) in gestational age, 7.9 g (95%CI: −13.71, −2.28) in birth weight, 0.8 cm in height (95%CI: −0.16, −0.02), 0.05 cm (95%CI: −0.08, − 0.01) in head circumference, and 0.3 (95%CI: −0.04, −0.02) in Apgar 5 score, except for the chest circumference. Trimester-specific exposure of PM2.5 and PM10 sometimes showed an opposite effect on Additionally, PM2.5 (OR = 1.37, 95%CI: 1.11, 1.68) was correlated with LBW.

Conclusion

Findings in this study suggest a combined impact of fine particulate matter exposure on neonatal development, which adds to the current understanding of PTB risk and health.
The role of boredom proneness and self-control in the association between anxiety and smartphone addiction among college students: a multiple mediation model
Authors: Zhang Li , Wang Baokai , Xu Qi , Fu Chang
Published: July 2023

Background

Smartphone addiction has been found to be a widespread public health issue, especially among youth. Previous studies reported a significant association between anxiety and smartphone addiction, but the underlying mechanism in this relationship is unclear. The purpose of this study was to investigate the mediating roles of boredom proneness and self-control in the relationship between anxiety and smartphone addiction.

Methods

Self-reported measures of anxiety, boredom proneness, self-control and smartphone addiction were administered to 1,526 Chinese college students.

Results

Smartphone addiction scores varied between 10 and 60 with an average of 30.89 ± 10.57 points. Anxiety had a direct and positive effect on smartphone addiction (effect = 0.18, 95% CI = 0.11–0.25), and an indirect effect on smartphone addiction through boredom proneness (effect = 0.10, 95% CI = 0.06–0.15) and self-control (effect = 0.16, 95% CI = 0.13–0.20). Boredom proneness and self-control sequentially mediated the relationship between anxiety and smartphone addiction (effect = 0.12, 95% CI = 0.10–0.15).

Conclusion

Anxiety is positively associated with smartphone addiction, and boredom proneness and self-control are important mediators in this relationship. Strengthening self-control and mitigating boredom could prevent smartphone addiction in anxious college students.
Combining spinal neuromodulation and activity based neurorehabilitation therapy improves sensorimotor function in cerebral palsy
Authors: Sachdeva Rahul , Girshin Kristin , Shirkhani Yousef , Gad Parag , Edgerton V. Reggie
Published: July 2023

Motor dysfunction in individuals with cerebral palsy (CP) such as the inability to initiate voluntary movements, walking with compensatory movement patterns, and debilitating spasticity is due to the aberrant neural connectivity between the brain and spinal cord. We tested the efficacy of noninvasive spinal cord neuromodulation (SCiP™, SpineX Inc.) with activity-based neurorehabilitation therapy (ABNT) in improving the sensorimotor function in six children with CP. Children received 8 weeks of either SCiP™ or sham therapy with ABNT (n = 3 per group). At the end of 8 weeks, all participants received 8 weeks of SCiP™ therapy with ABNT. Follow up assessments were done at week 26 (10 weeks after the last therapy session). Sensorimotor function was measured by the Gross Motor Function Measure 88 (GMFM88) test. We observed minimal change in sham group (mean 6% improvement), however, eight weeks of SCiP™ therapy with ABNT resulted in statistically and clinically relevant improvement in GMFM88 scores (mean 23% increase from baseline). We also observed reduced scores on the modified Ashworth scale only with SCiP™ therapy (−11% vs. +5.53% with sham). Similar improvements were observed in sham group but only after the cross over to SCiP™ therapy group at the end of the first eight weeks. Finally, sixteen weeks of SCiP™ therapy with ABNT resulted in further improvement of GMFM88 score. The improvement in GMFM88 scores were maintained at week 26 (10 weeks after the end of therapy), suggesting a sustained effect of SCiP™ therapy.
Federalism, an alternative to overcome the inequalities of sustainable development in the natural regions and macro regions of Peru
Authors: Coyla Zela Mario Aurelio , Morales Rocha José Luis , Lauracio Ticona Teófilo , Ramos Rojas Jarol Teófilo , Arroyo Japura Gregorio , Vargas Torres Nakaday Irazema
Published: July 2023

Political doctrines determine the formation of territorial units or geopolitical models more adequate to generate public value in subnational organizations, with positive results in the HDI, productivity indicators and national competitiveness oriented to improve the quality of public service for citizens who participate in democratic electoral processes with identity and that promote a decentralized State that does not generate development obstacles as an effect of geographical limits by departments and regional governments with inequalities in natural resources and comparative advantages, but that projects integration, better economic performance, sustainability, and sustainability for regional and national development and as an alternative to achieve political stability in Peru. The aim of this article is to explore whether the contribution of natural regions and macro-regions to sustainable development is unequal. Information from official web pages. The disparity index, analysis of variance (ANOVA) and Tukey's analysis were used. The GDP per capita of the coastal departments is 64% higher than that of the Andes and 136% higher than those of the Amazon; the HDI of the coast exceeds those regions by 31 and 19%; 44% of the urban population residing in marginal neighborhoods are on the coast, 67% in the Andes and 69% in the Amazon. The percentage of corruption is highest on the coast, followed by the Amazon. At the regional macro level, the primacy in GDP per capita and the HDI moves to the south, although the superiority of the corruption index persists in the center, followed by the south; both significantly higher than the east and north. This fact would reveal the possibility of a regional macro development without Lima and through axes of various development nodes, feasible in the era of globalization.
A democracy built on communicative action: Bahá'í political practice as a prefigurative resource for institutional effectiveness, accountability, and inclusivity
Authors: Sabet Michael
Published: July 2023

Goal 16 of the UN sustainable development goals, which calls on the global community to “build effective, accountable and inclusive institutions at all levels,” can be conceptualized as aiming at fostering communicative action, a concept developed by Jürgen Habermas to describe a mode for coordinating society grounded in deliberation. However, Habermas simultaneously provides an account of the structural transformation of the public sphere that suggests a hard limit on the capacity of mainstream capitalist liberal democracies to foster genuine communicative action in the relationships between institutions, individuals and communities. This paper therefore argues for the critical role of prefigurative politics, in which communities strive to internally embody desired socio-political forms rather than focusing on changing the wider socio-political order, as a vital resource for generating examples to inform institutional progress. The prefigurative example of the Baha'i community demonstrates norms and practices that may illustrate a path out of the dynamic Habermas identifies of system colonizing lifeworld, by fostering and protecting communicative action as the mode of social coordination. The form of communicative action found in the Baha'i community is situated in a context of atelic-organic model of relationships between individuals, communities and institutions. The paper contrasts the conceptual underpinnings of this model with individualistic conceptions of human nature that are argued to undermine liberal democracy's capacity for communicative action. At the core of communicative action within a Baha'i context is a distinctive model of deliberation, known within the community as “consultation”. The paper argues thatrational-critical consultationcan offer a vital nuance to Habermas' ideal of communicative action asrational-critical debatein the public sphere. The formal democratic structures and processes of the Bahá'í community are also explored as an institutional example that arguably meets the challenge of Goal 16. The paper concludes with initial reflections on a process by which the prefigurative example of a Baha'i model might be brought to bear on institutional performance in wider society.
Climate smart agriculture technologies adoption among small-scale farmers: a case study from Gujarat, India
Authors: Hebsale Mallappa Vinaya Kumar , Pathak Tapan Bharatkumar
Published: July 2023

In India, 78% of farmers are small and marginal, cultivating only 33% of the arable land but producing 50% of the food grain; their vulnerability to climate change poses a significant threat to the country’s food security. To enhance agricultural resilience, it is crucial to understand how these farmers perceive and integrate climate-smart technologies into their farming practices. A random sample of 240 farmers was selected for this study. An ex-post facto research design was employed to investigate farmers’ awareness of and adoption of CSAT and identify the significant variables influencing their decisions. The results indicate that approximately 74 per cent of farmers had low to medium awareness of CSAT, while around 83 per cent had low to medium adoption rates. Several factors were found to be significantly correlated with farmers’ awareness and adoption of CSAT, including education level, annual income, exposure to agricultural mass media, participation in extension programs, innovativeness, achievement motivation, risk orientation, and scientific orientation. Additionally, farmers faced various challenges in adopting CSAT, such as the high cost of inputs, limited knowledge about CSAT, and youth migration from rural areas. Based on the study’s findings, farmers emphasized the importance of involving them in decision-making processes related to the development of climate-smart technologies. They also highlighted the need for a timely supply of inputs and field visits to successful farms as effective means to promote awareness and adoption of CSAT. The comprehensive analysis of associated factors and empirical findings presented in this study will benefit private sector organizations, government extension agents, academics, and policymakers. By gaining insights into the determinants of CSAT adoption, these stakeholders can focus their efforts more effectively on promoting widespread adoption. Additionally, this study can inform policy decisions regarding the allocation of government resources to combat climate change.
Effects of Chinese herbal feed additives on the sperm quality and reproductive capacity in breeding boars
Authors: Tu Weilong , Zhang Weiyi , Wang Hongyang , Zhang Yingying , Huang Ji , Li Bushe , Li Xin , Tan Yongsong , Wu Xiao
Published: July 2023

Currently, Chinese herbal feed additives (CHFA) are commonly utilized in domestic pig farms. However, their impact on the sperm quality and reproductive capacity of imported breeding boars has yet to be thoroughly explored. In this study, the effect of CHFA on the sperm quality and reproductive capacity of the imported Duroc boars was investigated. Sixteen boars were randomly divided into control group and experimental (CHFA treated) group and fed normal or CHFA-levels containing diets, respectively. The sperm quality and reproductive hormone levels were periodically tested, and the reproductive capacity with breeding sows were evaluated. The results showed that the CHFA treated group boars significantly improved sperm volume, sperm concentration, and motility and reduced the sperm abnormalities. Furthermore, the serum levels of reproductive hormone such as follicle-stimulating hormone (FSH), luteinizing hormone (LH), and testosterone (T) in the CHFA treated group were significantly higher than those in the control group. Although there was no significant difference in the initial birth weight of piglets between the two groups, the CHFA treated group had a significantly higher average number of piglets born, the average number of piglets born alive, the number of piglets weaned at 28 days, and the weaning weight compared to the control group. These findings suggest that CHFA can significantly improve the sperm quality of breeding boars and enhance their reproductive hormone levels as well as the reproductive capacity, providing direct evidence for the further application of CHFA in the management of breeding boars in China.
Wine Companies’ Profitability in the Old World: Working Capital’s Impact
Authors: Candeias Teresa , Dias Diana
Published: July 2023

The purpose—The aim of this paper is to explain the relationship between working capital and profitability in the context of the wine industry. Design/methodology/approach—Artificial neural networks were used to analyze the relationship between working capital management and the profitability of Old World firms, based on a sample of 324 firms. Findings—The results suggest a positive relationship between the cash conversion cycle and the profitability of winery firms. Thus, an increase in the cash conversion cycle seems to increase wine companies’ profitability. Thus, managers can generate shareholder value by increasing the cash conversion cycle to a reasonable level. Regarding days of payable outstanding, there is a negative influence of the average payment term on the profitability of wine companies. This leads to the fact that the longer a company takes to pay its creditors, the less profitable it appears to be. In terms of days sales outstanding, the results suggest the existence of a negative impact of the average collection period on the profitability of winery firms. In other words, a reduction in the number of days a firm receives payment for sales positively affects the firm’s profitability. Finally, the results of the study show a positive relationship between days of outstanding inventory and the profitability of wineries, suggesting that wineries that maintain sufficiently high inventory levels have higher profitability. These results indicate that managers could create value for their shareholders if they managed their working capital more efficiently. Practical limitations/implications—The neural network can predict profits based on working capital management. However, the applied research methodology should be extended to other business typologies and wine firms of other countries to allow the generalization of results. Originality/value—This paper is the first study on the impact of working capital management on the financial performance of companies in the wine sector, particularly in the Old World. The results are an input to the wine business sector literature, one of the most representative of regional economies in the countries focused. The applied methodology can be adopted more broadly and underlies managerial implications. For future research, a similar analysis can be envisaged for the New World, and a comparison between the two blocks of countries, given the difference in characteristics and techniques of wine production, could be made.
Longitudinal Aerodynamic Characteristics of Ducted Fan Propelled Fixed-Wing VTOL Aircraft Hovering in Ground Effect
Authors: Zhao Yanxiong , Tian Yun , Wan Zhiqiang
Published: July 2023

The aerodynamic performances and control characteristics of vertical takeoff and landing aircraft will be significantly affected by the ground effect during takeoff and landing. The longitudinal aerodynamic characteristics and main flow features of a fixed-wing vertical takeoff and landing aircraft hovering in ground effect are investigated in this paper, using Multiple Reference Frame based numerical simulations. The aircraft is propelled by three ducted fans. Results show that the overall morphology of the flow is characterized by a fountain, ground vortex, reingestion, and recirculation. When the thrust distribution between the front and aft ducted fans changes, the flow features change as well. As the aircraft approaches the ground, the ducted fan thrust decreases, the fuselage lift increases, and the total lift first decreases and then increases. The maximum lift increases by 9.6% and the minimum lift decreases by 3.0% compared with that out-of-ground effect. The magnitude of the drag is about 1% of the lift, which has little influence on the aircraft’s performance. The pitching moment gradually changes from the equilibrium state to a significant nose-up moment. The total power consumed increases at a specific rotational speed.
A Cost-Effective Portable Multiband Spectrophotometer for Precision Agriculture
Authors: Fernández-Alonso Francisco Javier , Hernández Zulimar , Torres-Costa Vicente
Published: July 2023

The United Nations marks responsible consumption and production as one of the 17 key goals to fulfill the 2030 Agenda for Sustainable Development. In this context, affordable precision instruments can play a significant role in the optimization of crops in developing countries where precision agriculture tools are barely available. In this work, a simple to use, cost-effective instrument for spectral analysis of plants and fruits based on open-source hardware and software has been developed. The instrument is a 7-band spectrophotometer equipped with a microprocessor that allows one to acquire the reflectance spectrum of samples and compute up to 9 vegetation indices. The accuracy in reflectance measurements is between 0.4% and 1.4% full scale, just above that of high-end spectrophotometers, while the precision at determining the normalized difference vegetation index (NDVI) is 0.61%, between 3 and 6 times better than more expensive commercial instruments. Some use cases of this instrument have been tested, and the prototype has proven to be able to precisely monitor minute spectral changes of different plants and fruits under different conditions, most of them before they were perceptible to the bare eye. This kind of information is essential in the decision-making process regarding harvesting, watering, or pest control, allowing precise control of crops. Given the low cost (less than USD 100) and open-source architecture of this instrument, it is an affordable tool to bring precision agriculture techniques to small farmers in developing countries.
China-Australia Trade Relations and China’s Barley Imports
Authors: Liu Jingyi , Li Xiande , Sun Junmao
Published: July 2023

The high concentration of China’s barley import sources determines that China’s barley import trade is vulnerable to the impact of tariff policy adjustment. In particular, in 2020, China implemented anti-dumping and anti-subsidy policies against Australia, the largest source of barley imports. Therefore, whether China’s barley import trade will face import risks due to the adjustment of tariff policy has become a question worth discussing. Based on the above background, this study uses the partial equilibrium model to explore the impact of China’s adjustment of tariff policy on imported barley from Australia on China’s barley industry under the changing trade relations between China and Australia. Through analyzing the feasibility of developing domestic barley industry and expanding barley import sources, further explore strategies to deal with barley import trade risks. The results show that: Under the three import tariff adjustment simulations, the total import volume of China’s barley shows a downward trend, and the import price increases to varying degrees. However, the relatively small increase in domestic production suggests that the domestic barley market is less able to cope with the risk of a sharp drop in imports. At the same time, affected by the adjustment of tariff policy, some Chinese consumer demand is difficult to satisfy. China can deal with trade risks by implementing an import diversification strategy.
Effects of the Broken Kernel on Heat and Moisture Transfer in Fixed-Bed Corn Drying Using Particle-Resolved CFD Model
Authors: Liu Wenlei , Chen Guixiang , Zheng Deqian , Ge Mengmeng , Liu Chaosai
Published: July 2023

To investigate the pore structure distribution and the coupled heat and moisture transfer during the drying process of the grains, this study focuses on fixed-bed corn drying with varying levels of broken kernel rate. A model of internal flow and conjugate heat and mass transfer was established for the drying process. Random packing models of whole and half corn kernels with different proportions were generated using rigid body dynamics (RBD), and the porosity, airflow distribution, and coupling of temperature and moisture transfer in fixed beds with different levels of broken kernel rate were analyzed. A fixed-bed corn drying device was developed, and the effects of broken particle contents of 0%, 10%, 20%, and 30% on drying characteristics were studied. The research findings reveal that the radial porosity in the fixed bed exhibits an oscillating distribution, with the localized porosity decreasing as the broken kernel rate increases. Increasing the broken kernel rate intensifies the curvature of the airflow paths within the fixed bed, increasing the pressure drop in the bed. The broken kernels fill the gaps between the whole kernels, improving the uniformity of the velocity distribution within the fixed bed. Under various packing models, the average discrepancy between pressure drop obtained from Particle-resolved Computational Fluid Dynamics (PRCFD) simulations with experimental remains below 15%. The increase in broken kernel rate within the fixed bed enlarges the heat transfer area, resulting in an elevation of the transient heat transfer characteristic parameters during drying. Simultaneously, the broken kernel rate increases the surface area of mass transfer, thereby enhancing the moisture transfer rate within the fixed bed. Compared to the fixed bed without broken kernels (0%), which requires 560 min to dry the corn pile to a safe moisture of 14% (d.b.), the drying time is reduced by 60 min, 100 min, and 130 min for the respective broken kernel contents of 10%, 20%, and 30%, respectively. The PRCFD method successfully simulates the processes of convective heat and mass transfer in the fluid phase and thermal and mass diffusion in the solid phase, exhibiting a strong correlation with experimental data.
The Effect of Hydro-Priming and Proline Priming of Lettuce (Lactuca sativa L.) Seeds on Germination, Photosynthetic Pigments and Metal Metabolism under Cadmium Stress
Authors: Selović Alisa , Karalija Erna , Demir Arnela , Parić Adisa , Šamec Dunja
Published: July 2023

Cadmium (Cd) is considered one of the most toxic heavy metals to living organisms, being very persistent in soil and non-biodegradable, thus posing a long-term hazard to plants and humans. In recent years, the application of different molecules at the seed level, known as chemical seed priming, has been studied as a method to improve stress tolerance in plants. In the present study, we tested the effect of hydro-priming and proline priming of lettuce (Lactuca sativa L.) seeds on germination, photosynthetic pigments, and metal metabolism under cadmium stress. Plants primed with proline showed better germination under cadmium stress (100% versus 84% for non-primed and hydro-primed seeds). Priming with 20 mM of proline increased the chlorophyll a and total chlorophyll contents by 40.8% and 18.6%, respectively, while these parameters decreased in other seedlings under Cd stress. Similarly, 20 mM of proline improved the uptake of Zn and Fe in roots under Cd stress. This indicates that 20 mM of proline treatments may be beneficial for maintaining a normal photosynthetic capacity and mineral uptake under Cd stress, but further metabolomics and transcriptomic data should reveal the exact mechanisms of action.