bluuebunny/crossref_metadata_2025 huggingface dataset:
Suíte Intrusiva Rio Perdido: magmatismo intraplaca no sul do Cráton Amazônico – Bloco Rio Apa
Authors: Lima Gabrielle Aparecida de , Macambira Moacir José Buenano , Sousa Maria Zélia Aguiar de , Ruiz Amarildo Salina
Published: November 2017

O enxame de diques da Suíte Intrusiva Rio Perdido (SIRP) ocorre no sul do Cráton Amazônico, Bloco Rio Apa, e representa importante evento magmático de natureza fissural, pré-aglutinação do supercontinente Rodínia. Os diques são tabulares a lenticulares, com espessura variando entre 1 e 30 m, preferencialmente paralelos segundo as direções N70º-90ºE e N70º-90ºW, exibem contatos abruptos e discordantes à estruturação regional NS. Os diques são homogêneos, compostos por diabásios de granulação muito fina a fina e microgabros finos a médios, isotrópicos, sem quaisquer vestígios de deformação dúctil e metamorfismo. Ao microscópio, essas rochas apresentam-se holocristalinas, com textura ofítica a subofítica, intergranular, por vezes porfirítica, e localmente do tipo quenching, com morfologia do tipo “cauda de andorinha”. Constituem-se essencialmente por plagioclásio, piroxênios e olivina. Apresenta trend toleítico, com enriquecimento em FeOt em relação ao MgO para valores de álcalis relativamente constantes. As rochas dos diques classificam-se, quase que exclusivamente, como basaltos e basaltos andesíticos, e quanto à ambiência tectônica os diagramas sugerem para essas rochas uma colocação semelhante à dos basaltos intraplaca fanerozoicos. O comportamento dos elementos terras raras (ETR) mostra forte fracionamento de ETR pesados em relação aos ETR leves, com razões La/Yb entre 2,8 e 6,2 e anomalia negativa pouco expressiva ou inexistente de Eu. Considerando a idade de cristalização em torno de 1100 Ma para as rochas das suítes Rio Perdido e Huanchaca e do Complexo Rincón del Tigre, sugere-se a existência de Large Igneous Province (LIP) esteniana, associada à tentativa de ruptura continental relacionada à evolução do Aulacógeno Aguapeí.
New subtribe Pachitinae (Orchideae) of Orchidaceae: Evidence from morphological and molecular analyses
Authors: CHEN GUI-ZHEN , HUANG JIE , ZHANG GUO-QIANG , MA LIANG , CHEN SHI-PIN
Published: November 2017

The subtribal delimitation and relationships of Orchideae remain unresolved. In the present study, the phylogenetic relationships among all subtribes of Orchideae were reconstructed, utilizing five plastid and two nuclear DNA sequences (rbcL, trnS-trnG, matK, trnL-F, psbA-trnH, Xdh and ITS) from 178 taxa of Orchideae. The combined results show that most clades are successively sister to the grade of clades representing antecedently accepted subtribes, but Pachites and Huttonaea do not belong to the previous classification of Disinae. In contrast, these two genera represent two additional isolated lineages. On this basis, a new subtribe, Pachitinae, is tentatively proposed to accommodate this taxon. Also, the subtribe Huttonaeinae Schltr. was recovered (1926: 568). In addition to the taxonomic treatment of this subtribe, the delimitation of many related subtribes in Orchideae is discussed.
The Influence of the Reconquista on Muslim Law in Al-Andalus
Authors: Jakubowski Filip Andrzej
Published: November 2017

The Influence of the Reconquista on Muslim Law in Al-AndalusLife in the reality of the borderlands between the Muslim and Christian  worlds had significant influence on both sides. It also had an impact on Muslim law (sharia) which is observable in a very precious source – fatwas (Muslim legal rulings). Among those collected form the area of Al-Andalus (Muslim Spain and Portugal) and North Africa this paper discusses issues connected with the long-standing conflict between Christians and Muslims, known as the Reconquista. The problems include ransoming captives, defending Muslim towns or trade relations with Christians. This analysis reflects upon the impact of the Reconquista on everyday life, as it was seen in sharia. Wpływ rekonkwisty na prawo islamskie w Al-Andalus w świetle wybranych fatwŻycie na styku świata muzułmańskiego i chrześcijańskiego wpływało na obie strony. Odcisnęło także swe piętno na prawie muzułmańskim (szariacie), co można zaobserwować w bardzo cennym źródle – fatwach (muzułmańskich orzeczeniach prawnych). Niniejsza praca omawia problemy związane z rekonkwistą w oparciu o fatwy zebrane z obszaru Al-Andalus (muzułmańskiej Hiszpanii i Portugalii) oraz Afryki Północnej w kompilacji Al-Wanšarīsīego. Rozważane zagadnienia obejmują wykup jeńców, obronę muzułmańskich miast oraz relacje handlowe z chrześcijanami. Tym samym wyłania się obraz wpływu rekonkwisty na życie codzienne muzułmanów, tak jak został on zachowany w fatwach omawianego okresu.
The Perception of Yugoslav-Bulgarian Relations in the Daily “Politika” in the Context of the Pan-Balkan Entente Concept in the First Part of the 1930s.
Authors: Michalak Paweł
Published: November 2017

The Perception of Yugoslav-Bulgarian Relations in the Daily “Politika” in the Context of the Pan-Balkan Entente Concept in the First Part of the 1930s.The Yugoslav-Bulgarian rapprochement, initiated by the king Aleksandar I Karadjordjević in the early 30s of the twentieth century, with an idea of inclusion of Bulgaria to the planned Balkan Pact was one of the biggest reorientation in the Yugoslav policy at the turn of 20s and 30s. Since the end of the Great War, the eastern neighbour of Yugoslavia was treated rather as one of the greatest threats to the postwar order in the Balkans. This reorientation, resulting primarily from the geopolitical situation in Europe required propaganda action of warming the image of Bulgaria in the eyes of the Yugoslav society. This would not be possible without the support of the press, which in the first half of twentieth century, was still the most popular and definitely most accessible medium of information, which could significantly affected on the perception of current political events by the public opinion. The aim of the author was to present changes in the way of presenting the Yugoslav-Bulgarian relations in the daily Politika, the biggest and most read newspaper in the interwar Yugoslavia, in the context of political activities of king Aleksandar I towards the creation of the so-called Balkan Entente. Postrzeganie stosunków jugosłowiańsko-bułgarskich na łamach dziennika „Politika” w kontekście idei tzw. Ententy Bałkańskiej w pierwszej połowie lat 30. XX wiekuZbliżenie jugosłowiańsko-bułgarskie zainicjowane przez króla Aleksandra I Karađorđevicia w latach 30. XX w. z myślą o włączeniu Bułgarii do planowanego tzw. Paktu Bałkańskiego było jedną z najpoważniejszych reorientacji w jugosłowiańskiej polityce zagranicznej przełomu lat 20. i 30. XX w. Od zakończenia I wojny światowej wschodni sąsiad Jugosławii traktowany był raczej jako jedno z największych zagrożeń dla powojennego ładu na Bałkanach. Wspomniana reorientacja, wynikająca przede wszystkim z sytuacji geopolitycznej w ówczesnej Europie, wymagała ocieplenia wizerunku Bułgarów w oczach jugosłowiańskiego społeczeństwa. Zadanie to byłoby niemożliwe do realizacji bez wsparcia prasy, która w pierwszej połowie ubiegłego stulecia była nadal najbardziej popularnym i zdecydowanie najłatwiej dostępnym źródłem informacji mogącym realnie wpływać na odbiór bieżących wypadków politycznych przez opinię publiczną. Celem autora było przedstawienie zmiany sposobu prezentowania stosunków jugosłowiańsko-bułgarskich na łamach dziennika „Politika”, największego i najbardziej poczytnego czasopisma międzywojennej Jugosławii, w kontekście działań politycznych zmierzających do utworzenia tzw. Ententy Bałkańskiej.
Radomir Konstantinović and “Provincial Philosophy”: Binaries as Borders
Authors: Cox John Kayl
Published: November 2017

Radomir Konstantinović and Provincial Philosophy: Binaries as BordersThis essay is a partial reconsideration of the complex and often-cited work Filozofije palanke (1969) by the Serbian novelist and essayist Radomir Konstantinović. The fiery condemnations of Serbia’s stalled social and intellectual development and its accompanying predilection for barbaric violence are fiercely debated to this day, nearly six years after the death of the author and approaching fifty years since the book’s first publication. One way that Konstantinovic builds his argument is by establishing borders between Serbia, or other societies, and Europe or modernity; three main types of these borders can be expressed as binaries centered on values, time, and geography. The “spirit” or mindset of the palanka, or small Serbian town, can perhaps be rehabilited by converting it into a historically contingent philosophy, which comes to term with the forces of time, evolution, and agency. Radomir Konstantinović i filozofia prowincjalna. Przeciwstawności jako graniceEsej jest cząstkowym spojrzeniem na złożoną i często cytowaną pracę Filozofije palanke (1969) napisaną przez serbskiego powieściopisarza i eseistę Radomira Konstantinovicia. Ostra krytyka opóźnionego rozwoju społecznego i intelektualnego Serbii oraz towarzyszącego mu upodobania do barbarzyńskiej przemocy także dziś – prawie sześć lat po śmierci autora, i prawie pięćdziesiąt lat od pierwszego wydania książki, stanowią temat dyskusji. Jednym ze sposobów, w jaki Konstantinović buduje swoją argumentację, jest ustanowienie granicy między Serbią a innymi społeczeństwami, czy Europą i nowoczesnością. Trzy główne typy tych granic można wyrazić jako przeciwstawności skoncentrowane na wartościach, czasie i geografii. „Duch” lub sposób myślenia palanki, czyli serbskiego pipidówka, może zostać zrehabilitowany poprzez przekształcenie go w historycznie reprezentatywną filozofię, która mierzy się z siłami czasu, ewolucji i działań.
Evaluation of Cool-Season Extratropical Cyclones in a Multimodel Ensemble for Eastern North America and the Western Atlantic Ocean
Authors: Korfe Nathan G. , Colle Brian A.
Published: November 2017

This paper evaluates the extratropical cyclones within three operational global ensembles [the 20-member Canadian Meteorological Centre (CMC), 20-member National Centers for Environmental Prediction (NCEP), and 50-member European Centre for Medium-Range Weather Forecasts (ECMWF)]. The day-0–6 forecasts were evaluated over the eastern United States and western Atlantic for the 2007–15 cool seasons (October–March) using the ECMWF’s ERA-Interim dataset as the verifying analysis. The Hodges cyclone-tracking scheme was used to track cyclones using 6-h mean sea level pressure (MSLP) data. For lead times less than 72 h, the NCEP and ECMWF ensembles have comparable mean absolute errors in cyclone intensity and track, while the CMC errors are larger. For days 4–6 ECMWF has 12–18 and 24–30 h more accuracy for cyclone intensity than NCEP and CMC, respectively. All ensembles underpredict relatively deep cyclones in the medium range, with one area near the Gulf Stream. CMC, NCEP, and ECMWF all have a slow along-track bias that is significant from 24 to 90 h, and they have a left-of-track bias from 120 to 144 h. ECMWF has greater probabilistic skill for intensity and track than CMC and NCEP, while the 90-member multimodel ensemble (NCEP + CMC + ECMWF) has more probabilistic skill than any single ensemble. During the medium range, the ECMWF + NCEP + CMC multimodel ensemble has the fewest cases (1.9%, 1.8%, and 1.0%) outside the envelope compared to ECMWF (5.6%, 5.2%, and 4.1%) and NCEP (13.7%, 10.6%, and 11.0%) for cyclone intensity and along- and cross-track positions.
Evaluation of the effectiveness of a first aid health volunteers’ training programme using Kirkpatrick’s model: A pilot study
Authors: Vizeshfar Fatemeh , Momennasab Marzieh , Yektatalab Shahrzad , Iman Mohamad Taghi
Published: November 2017

Objective:

This study aimed to evaluate the effectiveness of a health volunteers’ complementary training programme on first aid.

Design:

Quasi-experimental study.

Setting:

A comprehensive health centre in the southwest of Iran.

Method:

The study was conducted in the second half of 2015 with all 25 health volunteers in the Qamar Bani Hashem comprehensive health centre, who had participated in the complementary training programme related to first aid. Volunteers’ satisfaction, learning, performance and the resulting outcomes of the training programme were evaluated using Kirkpatrick’s model.

Results:

At the first level of Kirkpatrick’s model, 36% ( n = 9) of the participants evaluated different aspects of the programme (including trainers, content and facilities) as excellent. At the second and third levels, the volunteers’ learning ( p < 0.0001) and performance ( p < 0.0001) had improved. At the fourth level, the mean ± standard deviation score of the programme outcome was 25.36 ± 2.27, indicating that the volunteers believed that the training course had been effective.

Conclusion:

An evaluation based on Kirkpatrick’s model showed that the volunteers’ training programme was able to increase the knowledge and skills of participants with regard to first aid. Using this model, we were able to assess the effectiveness of each of the components of the programme separately, together with the overall effectiveness of the programme.
Electrospinning of thermo-regulated sheath/core submicrometer fiber with galactitol hexa palmitate as a core
Authors: Ruirui Cao , Dongfang Pei , Shuqin Li , Sai Chen , Wei Li , Xingxiang Zhang
Published: November 2017

Galactitol hexa palmitate (GHP) as a phase change material (PCM) was fabricated via an esterification reaction of galactitol with palmitoyl chloride. A series of sheath/core composite submicrometer fibers were coaxially electro-spun using poly(acrylonitrile- co-vinylidene chloride) (P(AN- co-VDC)) as a sheath and the GHP as a core. The phase change properties, thermal stability, and the surface morphology of the fibers were characterized using field emission scanning electronic microscopy (FE-SEM), transmission electronic microscopy (TEM), differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA), etc. The results show that coaxial submicrometer fibers with a smooth surface and average diameter of 796 nm were electro-spun. The optimum feed rate of the sheath and core components for fabricating thermo-regulated submicrometer fibers with high enthalpies are 1.25 and 0.125 mL/h, respectively. The fiber can absorb 55 J/g of heat energy at approximately 23.2℃ and release 54 J/g at approximately 20.3℃. By contrast, the enthalpy of the P(AN- co-VDC)/GHP submicrometer fiber is higher than the previously published results.
Experimental investigation of carbon dioxide cross-contamination in sorption energy recovery wheel in ventilation system
Authors: Kassai Miklos
Published: November 2017

The aim of this research was to investigate the scale of carbon dioxide recirculation in rotary energy wheel operated in air handling units. To achieve this objective, a test facility was installed into the indoor air quality and thermal comfort laboratory of BUTE University. A newly developed molecular 3 Å sieve sorption wheel with high humidity transfer efficiencies is integrated into the experimental setup. In this research study, carbon dioxide cross-contamination rate from the exhaust side into the supply side in sorption regenerative air-to-air rotary energy exchanger was conducted by experimental tests. During the study, the correlation between the carbon dioxide cross-contamination, different rotational speeds of the wheel and different volume flow rates of supply air were also investigated in detail. Based on the results, a rotation speed diagram – carbon dioxide cross-contamination diagram – is plotted which can be very useful for researchers, developers and building service engineers in practice.

Practical application: The most perfect energy exchanger can transfer both heat and moisture, thus providing a pleasant indoor air quality in the conditioned space. It is beneficial if the exchanger can transfer heat and moisture between the supply and exhaust airstreams, thereby minimizing the capacity and energy consumption of the required auxiliary heater and humidifier. The auxiliary energy reduction can be especially high if the sorption material of the energy wheel is of type 3 Å molecular sieve that has an extremely high humidity transfer capacity. The disadvantage of the rotary energy recovery is the cross-contamination from the exhaust air to the supply air. This is very important because in places such as offices, schools, public institutions, carbon dioxide cross-contamination can cause degradation of indoor air quality.
Mentoring Emerging Leaders: Perspectives of Mentees on Dispositions and Conditions for Leadership Learning
Authors: Anderson Ryan D. , Wasonga Teresa A.
Published: November 2017

Although mentoring is believed to improve the craft of beginning principal, the context of collective engagement between mentor and mentee principals that optimize their leadership learning are rarely investigated. This study explored co-creating dispositional values, knowledge conversion modes, and enabling conditions as contexts that favor the creation and transmission of explicit and tacit knowledge for leadership learning for the mentee principal.
Barriers to Implementing the Response to Intervention Framework in Secondary Schools: Interviews With Secondary Principals
Authors: Bartholomew Mitch , De Jong David
Published: November 2017

Despite the successful implementation of the Response to Intervention (RtI) framework in many elementary schools, there is little evidence of successful implementation in high school settings. Several themes emerged from the interviews of nine secondary principals, including a lack of knowledge and training for successful implementation, the ability to identify specific interventions in each tier but recognized the lack of a tiered intervention process, and the identification of barriers one would expect if implementing RtI at the secondary level.
Strategies adopted during collaborative online music composition
Authors: Biasutti Michele
Published: November 2017

This pilot study analyzed the learning activities of adult musicians during the composition of a new musical work through online collaboration. The participants interacted in a virtual environment using synchronous and asynchronous tools to develop the composition project. The study utilized a mixed method descriptive design through video observation of the participants’ interactions during the online activities. In addition, individual semi-structured interviews were conducted with the participants after the learning sessions to analyze the method of work and the processes adopted. The findings showed that (1) the participants successfully completed the composing task in the virtual environment; (2) the following five learning activities were observed during the video recording analysis: experimenting, listening/evaluating, constructing, playing and technical issues; (3) the following two themes emerged from the semi-structured interview analysis: activities and processes. The results are discussed considering the educational implications of the processes activated during the activities.
Accuracy estimation in drilling small holes on engineering plastics by a mathematical approach
Authors: Uysal Alper , Altan Mihrigül
Published: November 2017

Engineering plastics have wide applications in different fields of industry due to their light weight and easy shaping. In manufacturing multi-component products, assembly is an inevitable stage and drilling is one of the necessary processes before joining of the components of these products. In this study, two of the most common types of engineering plastics, polyacetal (POM) and cast polyamide (castamide), were drilled with twist drills of 0.5 mm and 1 mm diameters, under different cutting speeds and feeds. In determining the accuracy of the drilled small holes, a mathematical approach was used in which least square circle method was applied and radial error of the each drilled hole was obtained. Thus, the hole accuracy could be determined without measuring equipment such as coordinate measurement machine. It has been seen that POM gave better hole accuracy than cast polyamide due its thermal and tribological properties. The effects of feed and cutting speed on the radial error were also investigated. POM did not show apparent difference in radial error according to the cutting parameters while cast polyamide showed lower radial error in higher feeds with 0.5 mm of drill tool and lower radial error with 1 mm of drill tool. Additionally, the radial error could be reduced with decrease of spindle speed at higher feed.
Erosive-abrasive wear behavior of carbide-free bainitic and boron steels compared in simulated field conditions
Authors: Vuorinen E , Heino V , Ojala N , Haiko O , Hedayati A
Published: November 2017

The wear resistance of carbide-free bainitic microstructures have recently shown to be excellent in sliding, sliding-rolling, and erosive-abrasive wear. Boron steels are often an economically favorable alternative for similar applications. In this study, the erosive-abrasive wear performance of the carbide-free bainitic and boron steels with different heat treatments was studied in mining-related conditions. The aim was to compare these steels and to study the microstructural features affecting wear rates. The mining-related condition was simulated with an application oriented wear test method utilizing dry abrasive bed of 8–10 mm granite particles. Different wear mechanisms were found; in boron steels, micro-cutting and micro-ploughing were dominating mechanisms, while in the carbide-free bainitic steels, also impact craters with thin platelets were observed. Moreover, the carbide-free bainitic steels had better wear performance, which can be explained by the different microstructure. The carbide-free bainitic steels had fine ferritic-austenitic microstructure, whereas in boron steels microstructure was martensitic. The level of retained austenite was quite high in the carbide-free bainitic steels and that was one of the factors improving the wear performance of these steels. The hardness gradients with orientation of the deformation zone on the wear surfaces were one of the main affecting factors as well. Smoother work hardened hardness profiles were considered beneficial in these erosive-abrasive wear conditions.
Investigation of the thermo-mechanical behaviour of clutches using fibre optic sensing technology with high spatial measurement density
Authors: Albers Albert , Ott Sascha , Kniel Jonas , Eisele Martin , Basiewicz Michael
Published: November 2017

Non-lubricated clutches are still subject of numerous investigations. Measuring the temperature distribution in the friction contact would deliver a more detailed view of the live friction process. Main restriction remaining to establish this information is the low spatial measurement density of conventional thermal measurement facilities. On this account, fibre optic sensing technology has been used for the first time to measure the temperature distribution with high spatial resolution in a pressure plate of a clutch system. One sensing fibre offers not less than 700 measurement points in the pressure plate. An academic example was carried out to validate the new measuring method. On one hand, the focus of this investigation was the comparison of the measured temperature between fibre and thermocouple. On the other hand, the manner of inserting the fibre, especially the influences on the part by inserting holes, was investigated. The target is minimally changing the friction contact by the measurement instrumentation. By means of this measurement method, it is possible to analyse the thermo-mechanical behaviour of a friction system with a high level of details. This method enables the control of temperature distribution in the counter plate. Currently, an optimization method is in development, which should make it possible to rate design changes, for example of the pressure plate, linked to the temperature distribution.
Long-term Effect of Injection Treatment for Osteoarthritis in the Knee by Orthokin Autologous Conditioned Serum
Authors: Zarringam Danial , Bekkers Joris E. J. , Saris Daniel B. F.
Published: November 2017

Background

Orthokin is an intra-articular autologous conditioned serum (ACS). Its use might have a beneficial biological effect on pain and function of osteoarthritis in the knee. However, earlier studies lack any consensus on its clinical application and disease modifying effect.

Objective

The aim of this study was to investigate the long-term effect of Orthokin injection treatment on prevention of surgical treatment for end-stage knee osteoarthritis.

Study Design

Prospective cohort study.

Methods

Patients of the previously published Orthokin cohort were contacted to determine whether any intra-articular surgical intervention or osteotomy of the study knee had taken place during the past decade. A log-rank test was performed to evaluate the differences in the survival distribution for the 2 types of intervention: Orthokin versus placebo.

Results

The survival distributions for the 2 interventions were not statistically significantly different, χ2(1) = 2.069, P = 0.150. After 7.5 ± 3.9 years, 46.3% of the placebo and 40.3% of the Orthokin group had been treated surgically.

Conclusion

The use of Orthokin in knee osteoarthritis patients did not result in a delay regarding surgical treatment.

Clinical Relevance

The intra-articular use of Orthokin does not seem to prevent or delay surgical intervention at 10 years after treatment for end-stage knee osteoarthritis.
Establishment of an antiviral assay system and identification of severe fever with thrombocytopenia syndrome virus inhibitors
Authors: Baba Masanori , Toyama Masaaki , Sakakibara Norikazu , Okamoto Mika , Arima Naomichi , Saijo Masayuki
Published: November 2017

Aims

Severe fever with thrombocytopenia syndrome (SFTS) is an emerging tick-borne infectious disease. SFTS is epidemic in Asia, and its fatality rate is around 30% in Japan. The causative virus severe fever with thrombocytopenia syndrome virus (SFTSV) is a phlebovirus of the family Phenuiviridae (the order Bunyavirales). Although effective treatments are required, there are no antiviral agents currently approved for clinical use. Ribavirin and favipiravir were examined for their anti-SFTSV activity and found to be selective inhibitors of SFTSV replication in vitro. However, their activity was not sufficient. Therefore, it is mandatory to identify novel compounds active against SFTSV. To this end, we have established a safe and rapid assay system for screening selective inhibitors of SFTSV.

Methods

The virus was isolated from SFTS patients treated in Kagoshima University Hospital. Vero cells were infected with SFTSV and incubated in the presence of various concentrations of test compounds. After three days, the cells were examined for their intracellular viral RNA levels by real-time reverse transcription-PCR without extracting viral RNA. The cytotoxicity of test compounds was determined by a tetrazolium dye method.

Results

Among the test compounds, the antimalarial agent amodiaquine was identified as a selective inhibitor of SFTSV replication. Its 50% effective concentration (EC50) and cytotoxic concentration (CC50) were 19.1 ± 5.1 and >100 µM, respectively. The EC50 value of amodiaquine was comparable to those of ribavirin and favipiravir.

Conclusion

Amodiaquine is considered to be a promising lead of novel anti-SFTSV agents, and evaluating the anti-SFTSV activity of its derivatives is in progress.
3,7-Dideazaneplanocin: Synthesis and antiviral analysis
Authors: Yin Xue-Qiang , Schneller Stewart W
Published: November 2017

Objective

To synthesize 3,7-dideazaneplanocin and evaluate its antiviral potential.

Methods

The target 3,7-dideazaneplanocin has been prepared in five steps from a readily available cyclopentenol. A thorough in vitro antiviral analysis was conducted versus both DNA and RNA viruses.

Results

A rational synthesis of 3,7-dideazaneplanocin was conceived and successfully pursued in such a way that it can be adapted to various analogs of 3,7-dideazaneplanocin. Using standard antiviral assays, no activity for 3,7-dideazaneplanocn was found.

Conclusion

Two structural features are necessary for adenine-based carbocyclic nucleosides (like neplanocin) for potential antiviral properties: (i) inhibition of S-adenosylhomocysteine hydrolase and/or (ii) C-5′ activation via the mono-nucleotide. These two requisite adenine structural features to fit these criteria are not present in in the target 3,7-dideazaneplanocin: (i) an N-7 is necessary for inhibition of the hydrolase and the N-3 is claimed to be essential for phosphorylation at C-5′. Thus, it is not surprising that 3,7-dideazaneplaoncin lacked antiviral properties.
Instrument Refinement: The Patient’s Perception of Life on Hemodialysis Scale
Authors: Twomey J. Creina , Way Christine Y. , Parfrey Patrick S. , Churchill David N. , Barrett Brendan J.
Published: November 2017

The objective of this study is to refine the Patient’s Perception of Hemodialysis Scale and data quality and refine the Patient’s Perception of Life on Hemodialysis Scale (PPHS). Collecting data from a convenient sample ( N = 236), data were collected and a cross-sectional design survey design was used. Item inclusion was based on the item’s theoretical underpinning, examination of data quality, findings from a multi-trait/multi-item correlation matrix, and criteria for item and scale characteristics. Data indicators were close to normal in terms of distribution. High and low statistics suggest that the entire scope of the characteristic being measured were experienced. All criteria related to this examination supported the inclusion/exclusion of remaining items and subscales. Subscales are able to measure the main concepts. Findings from this research have been analyzed, and the PPHS now includes five subscales (36 items) and is deemed a valid indicator of the hemodialysis patients’ perceptions of life. Nephrology nurses will be able to assess the patient’s illness and treatment experience, their perception of formal social supports, adjustment to life on hemodialysis, and design interventions.
Supergene gold enrichment in the Castromil-Serra da Quinta gold deposit, NW Portugal
Authors: Cruz C. , Noronha F. , Santos P. , Mortensen J. K. , Lima A.
Published: November 2017

Several gold deposits hosted mainly by Variscan granites and Precambrian to Palaeozoic metasediments occur in the northwestern part of Portugal. Most of these deposits were mined by the Romans (in the period I BC to II AD) as open pits and surface galleries. The Castromil-Serra da Quinta gold deposit is an important example of such a mined site; it occurs in the Dúrico-Beirã Au province located in the Central Iberian Zone (CIZ) in the western branch of European Variscan belt, mainly on the eastern flank of the Valongo anticline. Open pits and underground galleries at Castromil-Serra da Quinta exploited the gossan formed from the weathering of primary mineralization. The gossan is composed essentially of goethite, scorodite and clay minerals. A recent drilling campaign at Castromil-Serra da Quinta has provided samples of the primary mineralization below the oxidation level. Different modes of gold occurrence are defined based on metallographic studies of both the gossan and drill cores. Gold I occurs encapsulated in primary sulfide minerals, mainly arsenopyrite and pyrite; Gold II is also associated with the main primary sulfides, but occurs along grain boundaries and in microfractures of the sulfides or in associated quartz veins; and Gold III occurs as free gold particles in iron oxides within the gossan. In the gossan samples, it is difficult to distinguish whether the gold particles hosted in oxides correspond to Gold I, Gold II, or both, so these particles are described as Gold I–II and they are commonly surrounded by very much smaller particles of Gold III. Scanning electron microscope (SEM) and electron probe microanalysis (EPMA) data for the different gold particles reveal that Gold I is poorer in Ag (~15.5–39.76%) than Gold II (37.46–51.45%), whereas Gold III corresponds to native gold (<16.11% Ag). Gold III is thought to reflect gold enrichment in the upper level of the deposit, resulting from weathering processes that affected the primary Au (Bi) mineralization.
Immune-related tumour response assessment criteria: a comprehensive review
Authors: Somarouthu Bhanusupriya , Lee Susanna I , Urban Trinity , Sadow Cheryl A , Harris Gordon J , Kambadakone Avinash
Published: November 2017

Growing emphasis on precision medicine in oncology has led to increasing use of targeted therapies that encompass a spectrum of drug classes including angiogenesis inhibitors, immune modulators, signal transduction inhibitors, DNA damage modulators, hormonal agents etc. Immune therapeutic drugs constitute a unique group among the novel therapeutic agents that are transforming cancer treatment, and their use is rising. The imaging manifestations in patients on immune therapies appear to be distinct from those typically seen with conventional cytotoxic therapies. Patients on immune therapies may demonstrate a delayed response, transient tumour enlargement followed by shrinkage, stable size, or initial appearance of new lesions followed by stability or response. These newer patterns of response to treatment have rendered conventional criteria such as World Health Organization and response evaluation criteria in solid tumours suboptimal in monitoring changes in tumour burden. As a consequence, newer imaging response criteria such as immune-related response evaluation criteria in solid tumours and immune-related response criteria are being implemented in many trials to effectively monitor patients on immune therapies. In this review, we discuss the traditional and new imaging response criteria for evaluation of solid tumours, review the outcomes of various articles which compared traditional criteria with the new immune-related criteria and discuss pseudo-progression and immune-related adverse events.
Funding knowledgebases: Towards a sustainable funding model for the UniProt use case
Authors: Gabella Chiara , Durinx Christine , Appel Ron
Published: November 2017

Millions of life scientists across the world rely on bioinformatics data resources for their research projects. Data resources can be very expensive, especially those with a high added value as the expert-curated knowledgebases. Despite the increasing need for such highly accurate and reliable sources of scientific information, most of them do not have secured funding over the near future and often depend on short-term grants that are much shorter than their planning horizon. Additionally, they are often evaluated as research projects rather than as research infrastructure components.

In this work, twelve funding models for data resources are described and applied on the case study of the Universal Protein Resource (UniProt), a key resource for protein sequences and functional information knowledge. We show that most of the models present inconsistencies with open access or equity policies, and that while some models do not allow to cover the total costs, they could potentially be used as a complementary income source.

We propose the Infrastructure Model as a sustainable and equitable model for all core data resources in the life sciences. With this model, funding agencies would set aside a fixed percentage of their research grant volumes, which would subsequently be redistributed to core data resources according to well-defined selection criteria. This model, compatible with the principles of open science, is in agreement with several international initiatives such as the Human Frontiers Science Program Organisation (HFSPO) and the OECD Global Science Forum (GSF) project. Here, we have estimated that less than 1% of the total amount dedicated to research grants in the life sciences would be sufficient to cover the costs of the core data resources worldwide, including both knowledgebases and deposition databases.
Cariprazine – a novel antipsychotic drug and its place in the treatment of schizophrenia
Authors: Misiak Błażej , Bieńkowski Przemysław , Samochowiec Jerzy
Published: November 2017

Chociaż rozwój leków przeciwpsychotycznych drugiej generacji stanowił kamień milowy w leczeniu schizofrenii, w dalszym ciągu istnieje kilka problemów w dziedzinie leczenia, które nadal wymagają rozwiązania. Należy bowiem pamiętać, że dostępne preparaty przeciwpsychotyczne mają ograniczoną skuteczność w leczeniu objawów negatywnych i zaburzeń poznawczych. Co istotne, pierwotne objawy negatywne, czyli takie, które nie są spowodowane obecnością depresji, objawów pozapiramidowych lub wycofania związanego z przeżywaniem objawów psychotycznych, mogą dotyczyć nawet jednej czwartej pacjentów ze schizofrenią i wiążą się z gorszymi wynikami klinicznymi i funkcjonalnymi. Kariprazyna jest nowym lekiem przeciwpsychotycznym, częściowym agonistą receptorów D3 / D2, wykazuje także powinowactwo wobec kilku receptorów serotoniny. W niniejszym artykule przedstawiono charakterystykę właściwości farmakokinetycznych i farmakodynamicznych kariprazyny, wskazując na jej wyjątkowy profil receptorowy. Następnie omówiono wyniki opublikowanych dotychczas w literaturze kontrolowanych placebo, randomizowanych badań klinicznych z podwójnie ślepą próbą z zastosowaniem kariprazyny oraz prowadzonych analiz post-hoc. Badania te dostarczyły dowodów potwierdzających skuteczność stosowania kariprazyny w leczeniu zaostrzeń schizofrenii w porównaniu z placebo, podkreślając bezpieczeństwo jej stosowania i dobrą tolerancję. Ponadto, w jednym opublikowanym do tej pory badaniu klinicznym wykazano większą skuteczność kariprazyny w porównaniu do risperidonu w leczeniu dominujących objawów negatywnych, przy jednoczesnej poprawie funkcjonowania. Podsumowując, liczne dowody w dziedzinie terapii schizofrenii potwierdzają skuteczność stosowania kariprazyny w leczeniu epizodów jej zaostrzenia i podkreślają obiecujący poziom skuteczności w leczeniu dominujących objawów negatywnych.
Benchmarking a Scalable Approximate Dynamic Programming Algorithm for Stochastic Control of Grid-Level Energy Storage
Authors: Salas Daniel F. , Powell Warren B.
Published: November 2017

We present and benchmark an approximate dynamic programming algorithm that is capable of designing near-optimal control policies for a portfolio of heterogenous storage devices in a time-dependent environment, where wind supply, demand, and electricity prices may evolve stochastically. We found that the algorithm was able to design storage policies that are within 0.08% of optimal on deterministic models, and within 0.86% on stochastic models. We use the algorithm to analyze a dual-storage system with different capacities and losses, and show that the policy properly uses the low-loss device (which is typically much more expensive) for high-frequency variations. We close by demonstrating the algorithm on a five-device system. The algorithm easily scales to handle heterogeneous portfolios of storage devices distributed over the grid and more complex storage networks.

The online supplement is available at https://doi.org/10.1287/ijoc.2017.0768 .
Groups of Matrices That Act Monopotently
Authors: Hews Joshua , Livshits Leo
Published: November 2017

In the present article, the authors continue the line of inquiry started by Cigler and Jerman, who studied the separation of eigenvalues of a matrix under an action of a matrix group. The authors consider groups \Fam{G} of matrices of the form $\left[\small{\begin{smallmatrix} G & 0\\ 0& z \end{smallmatrix}}\right]$, where $z$ is a complex number, and the matrices $G$ form an irreducible subgroup of $\GL(\C)$. When \Fam{G} is not essentially finite, the authors prove that for each invertible $A$ the set $\Fam{G}A$ contains a matrix with more than one eigenvalue. The authors also consider groups $\Fam{G}$ of matrices of the form $\left[\small{\begin{smallmatrix} G & x\\ 0& 1 \end{smallmatrix}}\right]$, where the matrices $G$ comprise a bounded irreducible subgroup of $\GL(\C)$. When \Fam{G} is not finite, the authors prove that for each invertible $A$ the set $\Fam{G}A$ contains a matrix with more than one eigenvalue.
On the importance of presence within fandom spaces
Authors: Jensen Thessa
Published: November 2017

Presence and copresence in Goffman’s sense are some of the main building blocks of fandom groups in online spaces. This article provides a definition of both especially developed to take the online environment of fandom into account. At the same time, a framework for analysis and design of fandom spaces is developed and used on existing fandom spaces.
Distant reading the history of Swedish film politics in 4500 governmental SOU reports
Authors: Norén Fredrik , Snickars Pelle
Published: November 2017

Using computational methods, digitized collections and archives can today be scrutinized in their entirety. By distant reading and topic modeling one particular collection – 4500 digitized Swedish Governmental Official Reports (SOU) from 1922 to 1991 – this article gives a new archival perspective of the history of Swedish film politics and policy-making. We examine different probabilistic topics related to film (and media) that the algorithm within the topic modeling software Mallet extracted from the immense text corpora of all these Official Reports. Topic modeling is a computational method to study themes in texts by accentuating words that tend to co-occur and together create different topics. Basically, it is a research tool for the discovery of hidden semantic structures, exploring a collection through the underlying topics that run through it. Hence, our article captures a number of film discourses and trends within the SOU material. In conclusion, we argue that topic modeling should be recognized as a method and research aid for gathering an overview of a major material; as a way to pose new and unforeseen research questions; and as a kind of computational support that makes it possible to apprehend major patterns more or less impossible to detect through a traditional archival investigation.
DYNAMICS OF VIEWS ON ETHICS OF PEDAGOGICAL DIAGNOSTICS IN INFORMATION AND COMMUNICATION LEARNING ENVIRONMENT
Authors: Kolgatin O.
Published: November 2017

Didactical demands for pedagogical diagnostics and its realisation specific characters in information and communication learning environment of university are analysed. The questions of ethics and information security of pedagogical diagnostics are considered. Ethic aspects, connected with using of the automated pedagogical diagnostic systems, are underlined. Results of survey of students about their view points on issues of security of pedagogical diagnostics data are discussed.
AUTHOR’S EXPERIENCE IN TRAINING PUPILS OF SPECIALIZED OUTOF-SCHOOL EDUCATIONAL INSTITUTIONS TO RESEARCH WORK BY MEANS OF INFORMATIONAL AND COMMUNICATION TECHNOLOGIES
Authors: Voronkin O.
Published: November 2017

In the article the author’s experience in pupils’ training of Junior Academy of Sciences of Ukraine to research work by means of informational and communication technologies is presented.The three-tiered approach (popular science, experimental, fundamental levels) to the organization of personal oriented study in Physics covered such didactic principles as accessibility, visibility,scientific and systematic is considered. At the first level, pupils should be inculcated by interest in physics, its specificity, the terms etc. At the second level the experiment and demonstration of physical phenomena have a paramount importance, which aims to encourage students to make selffacilitated conclusions. At the third level the laboratory works and method of problem learning allow students to develop the ability independently to solve physical tasks. It is concluded that at each of these levels the means of information and communication technologies should be used. As an example, the author reviews the experience of open online course «Introduction to Physics of Sound», designed for pupils of specialized out-of-school educational institutions. We presented the main issues of the online course and examples of cognitive activity of pupils.
Plágio acadêmico: a percepção de estudantes de psicologia
Authors: Maia Rodrigo da Silva , Araújo Tereza Cristina Santos de , Maia Eulália Maria Chaves
Published: November 2017

Esta pesquisa buscou caracterizar a percepção de graduandos em Psicologia sobre o plágio acadêmico. Para isso, realizou-se a coleta dos dados, por meio de um questionário estruturado, com auxílio da técnica da evocação livre de palavras e através de uma questão discursiva. Os dados foram analisados a partir de estatísticas textuais e análise temática de conteúdo, em que participaram um total de 46 alunos. Crime e cópia foram as recordações mais prevalentes entre os estudantes, totalizando 32 e 29, respectivamente. Apesar de ser um tema em ascensão, parece ainda ser um campo obscuro entre os entrevistados
Abelhas (Hymenoptera: Apoidea) visitantes florais do sabiá (Mimosa Caesalpiniifolia Benth.) em Teixeira de Freitas, Bahia, Brasil
Authors: Döhler Thiago Lacerda , Pina Welber da Costa
Published: November 2017

Mimosa caesalpiniifolia, conhecida como sabiá, está distribuída por todo nordeste brasileiro e possui grande importância econômica, ecológica e ornamental. É considerada uma planta apícola por produzir grande quantidade de pólen e néctar e visitada, principalmente, por abelhas, que são consideras agentes polinizadores de suma relevância para diversas espécies de plantas. Este estudo teve por objetivo identificar as abelhas visitantes florais do sabiazerio localizados em um fragmento de Mata Atlântica no Extremo Sul da Bahia (Teixeira de Freitas). As coletas foram realizadas entre os meses de abril e maio de 2015, entre 06:00h e 18:00 h. totalizando 108 horas. A técnica utilizada foi coleta ativa, com auxílio de rede entomológica. Foram obtidas 232 abelhas, distribuídas em 11 espécies. As espécies mais abundantes foram Trigona spinipes e Apis mellifera que foram classificadas como constantes e dominantes, as demais foram consideradas acessórias e acidentais. Os horários de maiores visitações ocorreram entre 6h e 10h. A árvore sabiá apresentou maior pico de floração entre abril/maio e demonstra potencial para ser usada como fonte de recursos alimentares (em especial pólen). Por isso, a utilização racional da árvore sabiá poderá auxiliar na conservação e manutenção da comunidade de abelhas neste bioma.
Optimal Regulation of Invasive Species Long-Range Spread: A General Equilibrium Approach
Authors: McDermott Shana
Published: November 2017

Economic activity is implicated in the long-range spread of invasive species, resulting in ecological and economic damages. Current policies that are used to prevent such spread include specific and ad valorem taxes. However, these taxes are often created under ecological and economic uncertainty. To address this concern, this paper develops a general equilibrium model capable of evaluating the efficiency of specific and ad valorem taxes under uncertainty. Results show that specific taxes are more efficient at achieving a social optimum under imperfect information and that a combination of taxes is needed for multiple forms of long-range transmission.
Smoking within the Household: Spousal Peer Effects and Children’s Health Implications
Authors: Canta Chiara , Dubois Pierre
Published: November 2017

We study spousal peer effects on smoking and their implication for the health of children. Smoking decisions are modeled as equilibrium strategies of an incomplete information game within the couple. Using French data, we identify two peer effects: a smoking enhancing effect of smoking partners and a smoking deterring effect of non-smoking partners. An implication of these findings is that the smoking behavior may differ qualitatively in couples where both partners smoke and where only one partner smokes. This interpretation is supported by our finding that, controlling for total tobacco consumption of parents, the respiratory health of children is negatively affected only if both parents smoke.