bluuebunny/crossref_metadata_2025 huggingface dataset:
Performance Comparison of PVA/SA Composite Hydrogels for 3D Printing of Cartilage Scaffolds with Different Compositions
Authors: Chai Weihong , Yang Rongbin , Zhou Jiayi , Wei Qinghua
Published: February 2023

Physical blend is the method always used to modify the properties of composite hydrogels for 3D printing in tissue engineering. In this paper, polyvinyl alcohol (PVA) blending with sodium alginate (SA) was applied to enhance the mechanical properties of SA. The PVA/SA blending hydrogels with different components (5:5, 4:6, 3:7, 2:8, 1:9, and 0:10) were prepared through cross-linking method, and their properties were studied from microstructure, mechanical property, hydrophilicity, and printability, so the optimal composition ratio of the composite hydrogel can be selected for 3D printing cartilage scaffold. Results show that with PVA increasing in composite hydrogel, the pore size of the composite hydrogel becomes smaller and more even. The tensile strength and toughness of PVA/SA hydrogels increased firstly and then decreased with the increase of PVA content, and the composite hydrogel of 2PVA/8AS has the best tensile strength. Moreover, the water content and printability of hydrogels decrease with the increase of PVA, which is in good agreement with the pore structures of hydrogels. Based on the above results, we believe that 8AS/2PVA blend hydrogel is the most suitable for 3D printing cartilage scaffolds.
Improving Tribological Behaviors of Invar 36 Alloy under Extremely Cryogenic and Dry Conditions Through Surface Micro-Texturing
Authors: Wang Bin , Guo Yanbao , Zhang Zheng , Wang Deguo
Published: February 2023

Invar 36 alloy is an iron-nickel alloy with an ultra-low coefficient of thermal expansion, which is widely used in cryogenic fields of liquefied natural gas (LNG) and aerospace. However, the wear under extremely cryogenic and dry conditions is a key problem for Invar 36 alloy applied in the bearing of cryogenic submersible pump. In this work, we are mainly for improving the cryogenic tribological performance of Invar 36 alloy through laser surface texturing. Three different types of surface micro-textures were prepared on Invar 36 alloy specimens. And the effects of these micro-textures on the friction and wear properties of Invar 36 alloy were investigated. The results show that groove-channel micro-texture has the lowest coefficient of friction and wear rate under normal and -196 °C. Further research shows that this is because the channel structure of groove-channel micro-texture is more conducive to the transfer of most debris generated caused by wear, which successfully reduces the occurrence of abrasive wear. Scanning Electron Microscopy/Energy-dispersive X-ray spectroscopy was utilized to explain the cryogenic tribological performance of the micro-textures.
The Production Practice of Ultra-pure and Ultra-low-carbon Stainless Steel 07Cr17Ni12Mo2 by LF-VOD+ESR Steelmaking Process
Authors: Jia Xiaobin , Tu Mingjin , Yin Ranran , Chen Liangxiao , Zhao Wuyunbilige , Guo Wenbin
Published: February 2023

By reasonably controlling the vacuum degree, oxygen supply intensity, oxygen lance position, and other process parameters of Vacuum Oxygen Decarburization (VOD) refining furnace (60t), and according to the blowing situation, combined with the oxygen concentration difference potential, exhaust gas temperature and CO concentration, accurately determine the blowing end point, and then further remove inclusions in steel by Electro-Slag Remelting (ESR), making the end point C less than or equal to 0.06 %, the total content of (As + Sn + Pb + Sb + Bi) is less than or equal to 150 ppm, total oxygen content is less than or equal to 30 ppm. The content of class A, B, C and D inclusions is less than or equal to grade 1.0 and the total inclusion grade is less than or equal to grade 2.0.
Effects of Cold Spraying Process and Diamond Addition on Microstructure and Thermal Conductivity of Copper Matrix Composites
Authors: Wu Dan , Zhang Linwei , Zhang Youliang , Zeng Yanqi , Hu Qiang , Liu Qi , Liu Jin , Jia Jingxuan , Zou Jin
Published: February 2023

The operation speed and integration degree of electronic components are getting higher and higher, which puts forward higher requirements for electronic packaging materials. Diamond is added to copper matrix composites to improve the thermal conductivity. The effects of cold spraying process and diamond addition on the microstructure and thermal conductivity of copper matrix composites are studied. The results show that the copper matrix composite prepared by cold spraying is a deformed strip copper layer. The change of cycle times has little effect on the microstructure, while the flattening rate of the deformed copper layer decreases as the carrier gas temperature increases. The diamond particles are uniformly distributed at the copper grain boundary after adding copper plated diamond powder, which are closely bound to the copper matrix. Increasing the temperature is conducive to increasing the thermal conductivity, while the change of cycle times has little effect on it. The addition of 20% diamond particles reduces the thermal conductivity, so the diamond content should be increased to play its role in thermal conductivity.
Study the Test Method of Temperature and Humidity Monitoring Equipment in the Cold Chain Transportation Process
Authors: Zhao Xia , Pei Lining , Jia Xin , Qu Meng , Zhang Zheng , Wang Yuanyuan
Published: February 2023

Transportation objects include food cold chain logistics, flower, plant cold chain logistics, chemical cold chain logistics and other cold chain logistics. In order to improve the overall performance of the temperature and humidity monitoring equipment in the cold chain process, and further promote and improve the regional metering service system. This study is to analyze its dewpoint temperature stability, relative humidity stability and temperature stability to evaluate the performance of the dew point instrument. The results showed that the standard deviation of temperature, humidity and dew-point in reproducible experiments are 0.00°C, 0.07%RH and 0.01°C. The standard deviation of temperature, humidity and dew-point in stability experiments are 0.02°C, 0.33%RH and 0.066°C. Results show that the measurement method of this experiment meets the requirements of the measurement standards.
Pulse Bag Filter Fault Classifier Research and Analysis
Authors: Ding Wenjie , Cao Yichao , Yu Kai , Ma Mingxue , Hong Bin
Published: February 2023

Aiming at the problem of fault alarm flooding, a fault classifier is established to automatically classify fault types in combination with unsupervised learning methods in machine learning. The k-means method is used to classify the alarm types in dimensionality reduction, and the optimal K value is selected as 11 through various evaluation indexes, and the faults are added to the new category labels according to the center of each cluster after clustering. The random forest and support vector classification algorithm is used to establish a fault classifier model on the fault alarm dataset with new labels, and the unified analysis of the fault type prediction results of the test set unlabeled fault data set is compared with the random forest algorithm, support vector classification, and k-means method. The results show that the unity rate of the prediction results of the three types of classifiers on the test set when taking different K values can reach up to 67%, and the uniformity rate of the prediction results of the three models exceeds 0.998, which has a high degree of uniformity, indicating that the establishment of the fault alarm classifier for the pulse bag dust collector is feasible and has good classification accuracy, which can help maintenance personnel quickly locate and troubleshoot faults, and improve the intelligence level of equipment.
Design of Micro Five-axis CNC Machine Tool and Research on Virtual Simulation Machining
Authors: Cao Xuyan , Li Bin
Published: February 2023

By studying the structure and functional characteristics of five-axis linkage CNC machine tool, design five-axis CNC machine tool with X, Y, Z linear motion axes, B and C rotation axes. The virtual simulation system of miniature five-axis machine tool is built based on the VERICT, and an impeller part was simulated and processed as an example. Check whether the state of each moving axis in the machine tool movement is correct, and judge the rationality of the structure design of the machine tool based on the error information such as interference and collision in the processing. It is proved by simulation that the machine can realize five-axis linkage machining within the design range and meet the design requirements.
Seismic Vulnerability Analysis of Continuous Beam Bridge Based on Multivariate Copula Function
Authors: Gao Wei , Cao Qing , He Haoxiang , Cheng Yang
Published: February 2023

To solve the problem of low accuracy caused by only a single typical component which is selected to represent the overall vulnerability in the traditional analysis, continuous beam bridge is assumed as a ternary system composed of pier, abutment bearing and pier bearing. The damage degree of corresponding components is quantified by pier end curvature or damage index based on elastic-plastic energy dissipation difference and bearing displacement, and then the vulnerability analysis of components is carried out. Multivariate Copula function was introduced. On the basis of calculating the vulnerability curve of the main components, the method to solving the seismic vulnerability of the ternary component system was established.
Sowing Machine for Scallop Seedling in Bottom-culture
Authors: Li Mingzhi , Lu Hongbo , Chen Haiquan , He Ruilin , Sun Yuqing
Published: February 2023

The scallop is among the most important shellfish resource and is a proven candidate for aquaculture in many countries. In China, the scallop is generally bottom culture and artificial seeding. Artificial seeding on scallops is a difficult process with low production efficiency, high labor intensity, excessive cost low profit, and high rate of mortality and damage. In this paper, a sowing machine is developed for the bottom-sowing culture of the scallop. It consists of a transmission module, sows slide module, and buoyancy module. The structure and working mechanism of this machine are presented and analyzed in detail. The tests of experiments were conducted as well with the development machine. Through the simulation analysis of flow field of bottom-sown machine. The results show that the vortex area below the platform makes the scallop seedlings seedlings spread more evenly. In addition, the boat-shaped fairing at the head of the platform effectively reduces the water flow rate inside the platform, allowing the scallop seedlings to successfully leave the platform through the grille at the bottom of the platform after sowing. The control group efficiency is 26.67%; however, the optimized group efficiency average value is 57.97%. The cost of bottom sowing 1t scallop seedling was reduced from 1260 RMB to 124.4 RMB. It is proven that the design of the machine is feasible.
Research on Intelligent Control Method for Radial Spinning Pressure Balance of Three-roller Spinning
Authors: Lu Bo , Huang Tao , Luo Wei , Ma Lijun , Ma Xiaoliang , Chen Hongwei , Ma Shuai , Zheng Hongwei , Wang Wendong
Published: February 2023

Aiming at the imbalance of radial force in the traditional spinning process, an intelligent control method for radial spinning pressure balance of three-roller spinning machine is proposed. Firstly, an indirect measurement method of spinning pressure is proposed. By measuring the pressure in the two chambers of the output oil cylinder, the pressure of the rollers is calculated. Using the electro-hydraulic servo closed-loop control principle, the intelligent control of spinning pressure can be accomplished in one cycle by changing the rolling reduction of the roller. Secondly, three intelligent control methods of radial spinning pressure balance, sequential control method, simultaneous control method and immediate control method are proposed. Three evaluation indexes of workpiece wall thickness, radial runout and ellipticity are adopted. Influence rule of three different intelligent control methods of radial spinning pressure balance on workpiece spinning dimensional accuracy are studied by the evaluation indexes. The results show that the three evaluation indexes using the radial spinning pressure balance intelligent control method are significantly improved compared with the evaluation indexes without the radial spinning pressure balance control method. The size and precision of the parts are the best by the sequential control method.
Relative Position of Plug and Die on Forming Accuracy of Shaped Tube by Cold Drawing
Authors: Li Wei , Liu Shengqiang , Feng Pengni , Zhou Jing , Wang Baoyu
Published: February 2023

In the actual industrial production and manufacturing, tube drawing plays an extremely important role. In this study, a device with adjustable relative plug position is designed, the influence of relative plug position on the dimensional accuracy and the drawing force of drawn tube was investigated. The results show that different relative plug positions affect the inner and outer surface dimensions of the tube respectively. Therefore, the relative plug position can be distinguished according to the following rules in industrial production. When the position of the plug relative to the die is backward, the outer surface dimension of the drawn tube is qualified but the inner surface dimension is unqualified. When the position of the plug relative to the die is forward, the inner surface dimension of the drawn tube is qualified but the outer surface dimension is unqualified. The relative position of the plug is mainly due to the different radial force given to the tube by the plug and the die, resulting in the unqualified size of the drawn tube. When the plug is positioned backward relative to the die, the tube is subjected to the radial force of the plug first and then the radial force of the die. When the plug is positioned forward relative to the die, the tube is subjected to the radial force of the die first and then the radial force of the plug.
Design and Analysis of a Single-sided Hook-type Structural Lock with Eccentric Wheel
Authors: Zou Kaisa , Ma Zhifei , Zhang Yu , Chen Chuanzhi
Published: February 2023

In order to reduce the lander load during the docking process during the docking of the manned lunar lander and the cruise, this paper designs and introduces a kind of unilateral hook type structural lock with eccentric wheel. This mechanism can reduce the quality of the lander docking device and achieve the technical requirements of locking and unlocking between the two spacecraft. Based on the mathematical model and three-dimensional entity model of the structural lock device, the motion law is solved and simulated by Matlab and Adams software respectively. Then the theoretical and simulated motion data are compared to verify that the modified structure lock can complete the established design requirements.
The Modified Cubature Kalman Filter for Relative Navigation of Space Target Tracking
Authors: Zhang Ai , Zhang Chao , Zhao Xin , Jiu Yuanwei , Li Jing , Huang Gang , Liang Fengchao
Published: February 2023

At present, the trend of improving the mobility of fast acquisition, long-term tracking and high-precision control has been formed in China. The continuous observation ability of non-cooperative targets and good imaging performance in motion are important trends in the development of optical remote sensing technology. Aiming at the high-precision observation and real-time tracking requirements of high orbit space satellites, this paper studies the high-precision relative navigation of space non cooperative targets. In order to solve the problem that the estimation accuracy of Cubature Kalman filter (CKF) decreases when the system visibility is low, a modified Cubature Kalman filter (MCKF) based on the visibility is proposed. This algorithm defines a system visibility characterization method based on the error gain matrix of the filtering process, and proposes the visibility scaling parameter based on this method, The filter gain covariance matrix is adjusted online, so that the algorithm can adjust the weight of state prediction and system observation online according to the observability of the current time. Numerical simulation shows that compared with CKF, the estimation accuracy of MCKF is improved by about 4 times, and MCKF stabilizes faster and has higher accuracy.
Research on Registration Accuracy Detection Method Based on Machine Vision
Authors: Li Jialin , Wu Shuqin , Chang Kun , Wang Jia
Published: February 2023

The online printing machine registration control system can detect the overprint accuracy in real time during the printing process, so as to adjust the corresponding equipment to improve the print quality. The off-line overprint accuracy detection system ensures the stability and reliability of the detection results when detecting the print quality. Under this background, the research and experiment on the algorithm model of overprint accuracy detection of color prints based on machine vision system are carried out. Set up a hardware platform for printing registration accuracy detection with perfect machine vision, complete the collection of registration logo images. Convert the collected graphic sample information into data that can be processed by the computer. The collected image samples can be processed through the corresponding functions of the software platform interface, including graphic segmentation, visual enhancement, filtering and noise reduction, and edge extraction. Finally, the registration accuracy detection is completed through the neural network model for experimental analysis.
Control of Quadrotor Based on RBF Neural Network Adaptive Fast Terminal Sliding-Mode Strategy
Authors: Luo Huan , Zhang Song
Published: February 2023

I The purpose of this paper is to propose a fast adaptive terminal sliding mode control method for quadrotor unmanned aerial vehicles (UAVs) under dynamic uncertainties and external interference. Firstly, a complete mathematical dynamics model of a quadrotor UAV is presented. Secondly, a robust dual-loop nonlinear control law for the quadrotor velocity and attitude tracking is designed. Through the introduction of equivalent control inputs, the attitude control channels can be decoupled and attitude stabilized controllers can be designed separately. For velocity tracking and altitude tracking control, coupled controllers are designed to ensure velocity tracking based on the stability of altitude tracking control. The attitude loop adopts RBF neural network sliding mode control, to compensate for model disturbance uncertainty, adjust its gain in real time, and suppress chattering problems. Finally, the experimental results show that the designed controller can not only suppress external interference, but also achieve accurate tracking of the desired flight command.
Deep learning for automatic mandible segmentation on dental panoramic x-ray images
Authors: Machado Leonardo Ferreira , Watanabe Plauto Christopher Aranha , Rodrigues Giovani Aantonio , Junior Luiz Otavio Murta
Published: February 2023

Many studies in the last decades have correlated mandible bone structure with systemic diseases like osteoporosis. Mandible segmentation, as well as segmentation of other oral structures, is an essential step in studies that correlate oral structures’ conditions with systemic diseases in general. However, manual mandible segmentation is a time-consuming and training-required task that suffers from inter and intra-user variability. Further, the dental panoramic x-ray image (PAN), the most used image in oral studies, contains overlapping of many structures and lacks contrast on structures’ interface. Those facts make both manual and automatic mandible segmentation a challenge. In the present study, we propose a precise and robust set of deep learning-based algorithms for automatic mandible segmentation (AMS) on PAN images. Two datasets were considered. An in-house image dataset with 393 image/segmentation pairs was prepared using image data of 321 image patient data and the corresponding manual segmentation performed by an experienced specialist. Additionally, a publicly available third-party image dataset (TPD) composed of 116 image/segmentation pairs was used to train the models. Four deep learning models were trained using U-Net and HRNet architectures with and without data augmentation. An additional morphological refinement routine was proposed to enhance the models’ prediction. An ensemble model was proposed combining the four best-trained segmentation models. The ensemble model with morphological refinement achieved the highest scores on the test set (98.27%, 97.60%, 97.18%, ACC, DICE, and IoU respectively), with the other models scoring above 95% in all performance metrics on the test set. The present study achieved the highest ranked performance considering all the previously published results on AMS for PAN images. Additionally, those are the most robust results achieved since it was performed over an image set with considerable gender representativeness, a wide age range, a large variety of oral conditions, and images from different imaging scans.
Design and CT imaging of casper, an anthropomorphic breathing thorax phantom
Authors: Laidlaw Josie , Earl Nicolas , Shavdia Nihal , Davis Rayna , Mayer Sarah , Karaman Dmitri , Richtsmeier Devon , Rodesch Pierre-Antoine , Bazalova-Carter Magdalena
Published: February 2023

The goal of this work was to build an anthropomorphic thorax phantom capable of breathing motion with materials mimicking human tissues in x-ray imaging applications. The thorax phantom, named Casper, was composed of resin (body), foam (lungs), glow polyactic acid (bones) and natural polyactic acid (tumours placed in the lungs). X-ray attenuation properties of all materials prior to manufacturing were evaluated by means of photon-counting computed tomography (CT) imaging on a table-top system. Breathing motion was achieved by a scotch-yoke mechanism with diaphragm motion frequencies of 10−20 rpm and displacements of 1 to 2 cm. Casper was manufactured by means of 3D printing of moulds and ribs and assembled in a complex process. The final phantom was then scanned using a clinical CT scanner to evaluate material CT numbers and the extent of tumour motion. Casper CT numbers were close to human CT numbers for soft tissue (46 HU), ribs (125 HU), lungs (−840 HU) and tumours (−45 HU). For a 2 cm diaphragm displacement the largest tumour displacement was 0.7 cm. The five tumour volumes were accurately assessed in the static CT images with a mean absolute error of 4.3%. Tumour sizes were either underestimated for smaller tumours or overestimated for larger tumours in dynamic CT images due to motion blurring with a mean absolute difference from true volumes of 10.3%. More Casper information including a motion movie and manufacturing data can be downloaded from http://web.uvic.ca/~bazalova/Casper/.
Large subsets of Euclidean space avoiding infinite arithmetic progressions
Authors: Bradford Laurestine , Kohut Hannah , Mooroogen Yuveshen
Published: February 2023

It is known that if a subset of

R

\mathbb {R}

has positive Lebesgue measure, then it contains arbitrarily long finite arithmetic progressions. We prove that this result does not extend to infinite arithmetic progressions in the following sense: for each

λ
\lambda

in

[
0
,
1
)

[0,1)

, we construct a subset of

R

\mathbb {R}

that intersects every interval of unit length in a set of measure at least

λ
\lambda

, but that does not contain any infinite arithmetic progression.
A General Survey of the Slave Plantation.
Authors: Douglass Frederick
Published: February 2023

Home plantation of Colonel Lloyd — Its isolation — Its industries — The slave rule — Power of overseers — Author finds some enjoyment — Natural scenery — Sloop ‘Sally Lloyd’ — Wind mill — Slave quarter — ‘Old master’s’ house — Stables, store- houses, etc., etc. — The great house — Its surroundings — Lloyd — burial-place — Superstition of slaves — Colonel Lloyd’s wealth — Negro politeness — Doctor Copper — Captain Anthony — His family — Master Daniel Lloyd — His Brothers — Social etiquette.
Another Pressure of The Tyrant’s Vise.
Authors: Douglass Frederick
Published: February 2023

Experience at Covey’s summed up — First six months severer than the remaining six — Preliminaries to the change — Reasons for narrating the circumstances — Scene in the treading-yard — Author taken ill — Escapes to St. Michaels — The pursuit — Suffering in the woods — Talk with Master Thomas — His beating — Driven back to Covey’s — The slaves never sick — Natural to expect them to...
The Runaway Plot.
Authors: Douglass Frederick
Published: February 2023

New Year’s thoughts and meditations — Again hired by Freeland — Kindness no compensation for slavery — Incipient steps toward escape — Considerations leading thereto — Hostility to slavery — Solemn vow taken — Plan divulged to slaves — Columbian Orator again — Scheme gains favor — Danger of discovery — Skill of slaveholders — Suspicion and coercion — Hymns with double meaning — Consultation — Pass-word — Hope and fear — Ignorance of geography — Imaginary difficulties — Patrick Henry — Sandy a dreamer — Route...
Hope For The Nation.
Authors: Douglass Frederick
Published: February 2023

Proclamation of emancipation — Its reception in Boston — Objections brought against it — Its effect on the country — Interview with President Lincoln — New York riots — Re-election of Mr. Lincoln — His inauguration, and inaugural — Vice-President Johnson — Presidential reception — The fall of Richmond — Faneuil Hall — The assassination — Condolence.
Incidents and Events.
Authors: Douglass Frederick
Published: February 2023

Hon. Gerrit Smith and Mr. E. C. Delevan — Experiences at hotels and on steamboats and other modes of travel — Hon. Edward Marshall — Grace Greenwood — Hon. Moses Norris — Robert G. Ingersoll — Reflections and conclusions — Compensations.
‘Honor to Whom Honor.’
Authors: Douglass Frederick
Published: February 2023

Grateful recognition — Friends in need — Lucretia Mott — Lydia Maria Child — Sarah and Angelina Grimke — Abby Kelley — H. Beecher Stowe — Other Friends — Woman Suffrage.
Appendix.
Authors: Douglass Frederick
Published: February 2023

ORATION BY FREDERICK DOUGLASS, DELIVERED ON THE OCCASION OF THE UNVEILING OF THE FREEDMEN’s MONUMENT, IN MEMORY OF ABRAHAM LINCOLN, IN LINCOLN PARK, WASHINGTON, D.C., APRIL 14, 1876.

Friends and Fellow Citizens:

I warmly congratulate you upon the highly interesting object which has caused...
Later Life.
Authors: Douglass Frederick
Published: February 2023

Again summoned to the defense of his people — The difficulties of the task — The race problem — His life work — The anti-slavery movement.
Doubts As to Garfield’s Course.
Authors: Douglass Frederick
Published: February 2023

Garfield not a stalwart — Encounter of Garfield with Tucker — Hope in promises of a new departure — The sorrow-stricken nation.
Oke of Okehurst;
Authors: Lee Vernon , Worth Aaron
Published: February 2023

i

That sketch up there with the boy’s cap? Yes; that’s the same woman. I wonder whether you could guess who she was. A singular being, is she not? The most marvellous creature, quite, that I have ever met: a wonderful elegance, exotic, far-fetched, poignant;...
Dionea
Authors: Lee Vernon , Worth Aaron
Published: February 2023

From the Letters of Doctor Alessandro De Rosis to the Lady Evelyn Savelli, Princess of Sabina.*

Montemirto
Ligure,* June 29, 1873.

I take immediate advantage of the generous offer of your Excellency (allow an old Republican* who has held you...
PRINCE ALBERIC AND THE SNAKE LADY
Authors: Lee Vernon , Worth Aaron
Published: February 2023

to her highness

THE RANEE OF SARÀWAK*

In the year 1701, the Duchy of Luna* became united to the Italian dominions of the Holy Roman Empire, in consequence of the extinction of its famous ducal house in the persons of...
MARSYAS IN FLANDERS*
Authors: Lee Vernon , Worth Aaron
Published: February 2023

I

“You are right. This is not the original crucifix at all. Another one has been put instead. Il y a eu substitution,” and the little old Antiquary of Dunes* nodded mysteriously, fixing his ghostseer’s eyes upon mine.

He said it in...
CHAPTER IV
Authors: Austen Jane , Mullan John
Published: February 2023

A very few days had passed after this adventure, when Harriet came one morning to Emma with a small parcel in her hand, and after sitting down and hesitating, thus began:

‘Miss Woodhouse — if you are at leisure — I have something that I should like to tell...
CHAPTER VI
Authors: Austen Jane , Mullan John
Published: February 2023

After being long fed with hopes of a speedy visit from Mr. and Mrs. Suckling, the Highbury world were obliged to endure the mortification of hearing that they could not possibly come till the autumn. No such importation of novelties could enrich their intellectual...
CHAPTER VII
Authors: Austen Jane , Mullan John
Published: February 2023

They had a very fine day for Box Hill; and all the other outward circumstances of arrangement, accommodation, and punctuality, were in favour of a pleasant party. Mr. Weston directed the whole, officiating safely between Hartfield and the vicarage, and every body was in...
The Carpet-Bag
Authors: Melville Herman , Blum Hester
Published: February 2023

I stuffed a shirt or two into my old carpet-bag, tucked it under my arm, and started for Cape Horn and the Pacific. Quitting the good city of old Manhatto, I duly arrived in New Bedford. It was on a Saturday night in...
The Counterpane
Authors: Melville Herman , Blum Hester
Published: February 2023

Upon waking next morning about daylight, I found Queequeg’s arm thrown over me in the most loving and affectionate manner. You had almost thought I had been his wife. The counterpane was of patchwork, full of odd little parti-colored squares and triangles; and this...
Merry Christmas
Authors: Melville Herman , Blum Hester
Published: February 2023

At length, towards noon, upon the final dismissal of the ship’s riggers, and after the Pequod had been hauled out from the wharf, and after the ever-thoughtful Charity had come off in a whale-boat, with her last gift — a nightcap for Stubb, the second mate,...
Queen Mab
Authors: Melville Herman , Blum Hester
Published: February 2023

Next morning Stubb accosted Flask.

“Such a queer dream, King-Post, I never had. You know the old man’s ivory leg, well I dreamed he kicked me with it; and when I tried to kick back, upon my soul, my little man, I kicked my leg...
Cetology
Authors: Melville Herman , Blum Hester
Published: February 2023

Already we are boldly launched upon the deep; but soon we shall be lost in its unshored harborless immensities. Ere that come to pass; ere the Pequod’s weedy hull rolls side by side with the barnacled hulls of the leviathan; at the...
Sunset
Authors: Melville Herman , Blum Hester
Published: February 2023

The cabin; by the stern windows; Ahab sitting alone, and gazing out.
Moby Dick
Authors: Melville Herman , Blum Hester
Published: February 2023

I, Ishmael, was one of that crew; my shouts had gone up with the rest; my oath had been welded with theirs; and stronger I shouted, and more did I hammer and clinch my oath, because of the dread in my soul. A...
The Town-Ho’s Story
Authors: Melville Herman , Blum Hester
Published: February 2023

(As told at the Golden Inn)

The Cape of Good Hope, and all the watery region round about there, is much like some noted four corners of a great highway, where you meet more travellers than in any other part.

It was not...
The Whale as a Dish
Authors: Melville Herman , Blum Hester
Published: February 2023

That mortal man should feed upon the creature that feeds his lamp, and, like Stubb, eat him by his own light, as you may say; this seems so outlandish a thing that one must needs go a little into the history and philosophy of...
Cutting In
Authors: Melville Herman , Blum Hester
Published: February 2023

It was a Saturday night, and such a Sabbath as followed! Ex officio professors of Sabbath breaking are all whalemen. The ivory Pequod was turned into what seemed a shamble; every sailor a butcher. You would have thought we were offering up ten thousand...
The Funeral
Authors: Melville Herman , Blum Hester
Published: February 2023

“Haul in the chains! Let the carcase go astern!”

The vast tackles have now done their duty. The peeled white body of the beheaded whale flashes like a marble sepulchre; though changed in hue, it has not perceptibly lost anything in bulk. It is...
The Great Heidelburgh Tun
Authors: Melville Herman , Blum Hester
Published: February 2023

Now comes the Baling of the Case. But to comprehend it aright, you must know something of the curious internal structure of the thing operated upon.

Regarding the Sperm Whale’s head as a solid oblong, you may, on an inclined plane, sideways divide it...
Cistern and Buckets
Authors: Melville Herman , Blum Hester
Published: February 2023

Nimble as a cat, Tashtego mounts aloft; and without altering his erect posture, runs straight out upon the overhanging mainyardarm, to the part where it exactly projects over the hoisted Tun. He has carried with him a light tackle called a whip, consisting of...
Leg and Arm
Authors: Melville Herman , Blum Hester
Published: February 2023

“Ship, ahoy! Hast seen the White Whale?”

So cried Ahab, once more hailing a ship showing English colors, bearing down under the stern. Trumpet to mouth, the old man was standing in his hoisted quarter-boat, his ivory leg plainly revealed to the stranger...
The Fossil Whale
Authors: Melville Herman , Blum Hester
Published: February 2023

From his mighty bulk the whale affords a most congenial theme whereon to enlarge, amplify, and generally expatiate. Would you, you could not compress him. By good rights he should only be treated of in imperial folio. Not to tell over again his furlongs...
The Forge
Authors: Melville Herman , Blum Hester
Published: February 2023

With matted beard, and swathed in a bristling shark-skin apron, about mid-day, Perth was standing between his forge and anvil, the latter placed upon an iron-wood log, with one hand holding a pike-head in the coals, and with the other at his forge’s lungs,...
The Pequod Meets the Bachelor
Authors: Melville Herman , Blum Hester
Published: February 2023

And jolly enough were the sights and the sounds that came bearing down before the wind, some few weeks after Ahab’s harpoon had been welded.

It was a Nantucket ship, the Bachelor, which had just wedged in her last cask of oil, and bolted...
The Deck Towards the End of the First Night Watch
Authors: Melville Herman , Blum Hester
Published: February 2023

Ahab standing by the helm. Starbuck approaching him

“We must send down the main-top-sail yard, sir. The band is working loose, and the lee lift is half-stranded. Shall I strike it, sir?”

“Strike nothing; lash it. If I had sky-sail poles, I’d sway them...
The Needle
Authors: Melville Herman , Blum Hester
Published: February 2023

Next morning the not-yet-subsided sea rolled in long slow billows of mighty bulk, and striving in the Pequod’s gurgling track, pushed her on like giants’ palms outspread. The strong, unstaggering breeze abounded so, that sky and air seemed vast outbellying sails; the...
The Pequod Meets the Rachel
Authors: Melville Herman , Blum Hester
Published: February 2023

Next day, a large ship, the Rachel, was descried, bearing directly down upon the Pequod, all her spars thickly clustering with men. At the time the Pequod was making good speed through the water; but as the broad-winged windward stranger shot nigh to her,...
The Symphony
Authors: Melville Herman , Blum Hester
Published: February 2023

It was a clear steel-blue day. The firmaments of air and sea were hardly separable in that all-pervading azure; only, the pensive air was transparently pure and soft, with a woman’s look, and the robust and man-like sea heaved with long, strong, lingering swells,...
The Chase — First Day
Authors: Melville Herman , Blum Hester
Published: February 2023

That night, in the mid-watch, when the old man — as his wont at intervals — stepped forth from the scuttle in which he leaned, and went to his pivot-hole, he suddenly thrust out his face fiercely, snuffing up the sea air as a sagacious ship’s dog will,...
G-RANK: an equivariant graph neural network for the scoring of protein–protein docking models
Authors: Kim Ha Young , Kim Sungsik , Park Woong-Yang , Kim Dongsup
Published: February 2023

Motivation

Protein complex structure prediction is important for many applications in bioengineering. A widely used method for predicting the structure of protein complexes is computational docking. Although many tools for scoring protein–protein docking models have been developed, it is still a challenge to accurately identify near-native models for unknown protein complexes. A recently proposed model called the geometric vector perceptron–graph neural network (GVP-GNN), a subtype of equivariant graph neural networks, has demonstrated success in various 3D molecular structure modeling tasks.

Results

Herein, we present G-RANK, a GVP-GNN-based method for the scoring of protein-protein docking models. When evaluated on two different test datasets, G-RANK achieved a performance competitive with or better than the state-of-the-art scoring functions. We expect G-RANK to be a useful tool for various applications in biological engineering.

Availability and implementation

Source code is available at https://github.com/ha01994/grank.

Contact

kds@kaist.ac.kr

Supplementary information

Supplementary data are available at Bioinformatics Advances online.
Follicular fluid progesterone downregulated HPGD and COX2 in granulosa cells via suppressing NF-ĸB in endometriosis
Authors: Li Jing-Yi , Chen Jian-Peng , Qian Yu-Li , Ma Jun-Yan , Ni Fei-Da , Lin Yi-Feng , Zhang Run-Ju , Ying Yue , Zhang Yan-Ye , Wang Si-Wen , Huang Yun , Liu Juan , Tu Mi-Xue , Ying Yan-Yun , Wu Yi-Qing , Wu Xue-Chen , Wu Bing-Bing , Zhu Bo , Zhang Dan
Published: February 2023

Increasing evidences showed that ovulatory dysfunction, possibly caused by luteinized unruptured follicular follicle syndrome (LUFS), is one of the reasons for endometriosis-related infertility. The present study was conducted to explore the potential effect of elevated progesterone in follicular fluid (FF) on ovulation in endometriosis. A prospective study including 50 ovarian endometriosis patients and 50 control patients with matched pairs design was conducted with alterations in FF and peritoneal fluid (PF) components identified by metabolomics analyses and differentially expressed genes in granulosa cells (GCs) identified by transcriptome analysis. Patients with endometriosis exhibited a significantly higher progesterone level in serum, FF, and PF. Granulosa cells from endometriosis patients revealed decreased expression of HPGD, COX-2, and suppressed NF-ĸB signaling. Similarly, progesterone treatment in vitro downregulated HPGD and COX2 expression and suppressed NF-ĸB signaling in granulosa tumor-like cell line KGN (Bena Culture Collection, China) and primarily cultured GCs, as manifested by decreased expressions of IL1R1, IRAK3, reduced pIĸBα/IĸBα ratio, and nucleus translocation of p65. On the contrary, TNF-α treatment increased expression of IL1R1, IRAK3, pIĸBα, p65, and HPGD in GCs. One potential p65 binding site was identified in the promoter region of HPGD by chromatin immunoprecipitation. In conclusion, we found that intrafollicular progesterone might downregulate HPGD and COX-2 in GCs via suppressing the NF-ĸB signaling pathway, shedding light on the mechanism underlying the endometriosis-related ovulatory dysfunction.
The autism spectrum among transgender youth: default mode functional connectivity
Authors: Strang John F , McClellan Lucy S , Li Sufang , Jack Allison E , Wallace Gregory L , McQuaid Goldie A , Kenworthy Lauren , Anthony Laura G , Lai Meng-Chuan , Pelphrey Kevin A , Thalberg Alexandra E , Nelson Eric E , Phan Jenny M , Sadikova Eleonora , Fischbach Abigail L , Thomas John , Vaidya Chandan J
Published: February 2023

The common intersection of autism and transgender identities has been described in clinical and community contexts. This study investigates autism-related neurophenotypes among transgender youth. Forty-five transgender youth, evenly balanced across non-autistic, slightly subclinically autistic, and full-criteria autistic subgroupings, completed resting-state functional magnetic resonance imaging to examine functional connectivity. Results confirmed hypothesized default mode network (DMN) hub hyperconnectivity with visual and motor networks in autism, partially replicating previous studies comparing cisgender autistic and non-autistic adolescents. The slightly subclinically autistic group differed from both non-autistic and full-criteria autistic groups in DMN hub connectivity to ventral attention and sensorimotor networks, falling between non-autistic and full-criteria autistic groups. Autism traits showed a similar pattern to autism-related group analytics, and also related to hyperconnectivity between DMN hub and dorsal attention network. Internalizing, gender dysphoria, and gender minority-related stigma did not show connectivity differences. Connectivity differences within DMN followed previously reported patterns by designated sex at birth (i.e. female birth designation showing greater within-DMN connectivity). Overall, findings suggest behavioral diagnostics and autism traits in transgender youth correspond to observable differences in DMN hub connectivity. Further, this study reveals novel neurophenotypic characteristics associated with slightly subthreshold autism, highlighting the importance of research attention to this group.
A rare variant of a ruptured sinus of valsalva aneurysm forming an aorto-atrial fistula: a case report and review of literature
Authors: Dayco John S , Dsouza Alyssa , Baciewicz Frank , Cardozo Shaun
Published: February 2023

Background

Sinus of valsalva aneurysms (SOVAs) are infrequent findings and generally diagnosed incidentally. A SOVA may be at risk for rupture, which would lead to an aorto-cardiac shunt. These patients present similarly to decompensated heart failure.

Case Presentation

We present a case of a 44-year-old female with a ruptured non-coronary SOVA diagnosed by echocardiogram during evaluation for exertional dyspnoea. A trans-oesophageal echocardiogram (TEE) revealed a 2.1 cm non-coronary SOVA with windsock communication to the right atrium. The patient refused surgery, and two years later, presented with florid right heart failure with preserved left ventricular function. The right ventricle was severely dilated and hypokinetic with right atrial enlargement. After finally agreeing to surgery, a pre-operative catheterization revealed non-obstructive coronaries and a significant left to right shunt with elevated pulmonary pressure. The patient had suboptimal response to diuretic therapy and was sent for successful repair of the aneurysm with the closure of the aorto-atrial fistula via bovine pericardial patch and resolution of the left to right shunt as demonstrated by intra-operative TEE. Her right-sided heart failure symptoms subsequently resolved.

Discussion

SOVA is a rare finding but should still be considered in the differential in young and middle-aged patients with symptoms of acute heart failure, hemodynamic compromise, and a new continuous heart murmur. Early surgical repair is highly recommended to prevent acute and long-term complications.
Aboveground responses to belowground root damage detected by non-destructive sensing metrics in three tree species
Authors: Azar Matan , Mulero Gabriel , Oppenheimer-Shaanan Yaara , Helman David , Klein Tamir
Published: February 2023

Root systems form a significant part of tree biomass and function. Yet, roots are hidden from our eyes, making it difficult to track the belowground processes. By contrast, our capacity to detect aboveground changes in trees has been continuously improving using optical methods. Here, we tested two fundamental questions: (1) To what extent can we detect aboveground responses to mechanical damage of the root system? (2) To what extent are roots redundant? We applied three different non-destructive remote sensing means: (1) optical means to derive leaf greenness, (2) infrared means to detect the changes in leaf surface temperature and (3) spectral means to derive five vegetation indices (i.e. the photochemical reflectance index (PRI), the chlorophyll photosynthesis index (CIRed-edge), the anthocyanin reflectance index 1, the structure insensitive pigment index and the normalized difference water index (NDWI)). We recorded the above metrics for hours and days and up to a month following induced root damage in three key Mediterranean tree species: Aleppo pine (Pinus halepensis Mill.), Palestine oak (Quercus calliprinos Webb.) and Carob (Ceratonia siliqua L.). To induce root damage, we removed 25, 50 and 75 percent of the root system in each species and compared it with control saplings. Tree aboveground (canopy) responses to root damage increased over time and with damage level. Leaf warming (up to 3°C) and decreased PRI were the most significant and rapid responses, with temperature differences being visible as early as 2 days following root damage. NDWI and greenness were the least sensitive, with responses detectable only at 75 percent root damage and as late as 14 or 30 days following root damage. Responses varied vastly among species, with carob being the most sensitive and pine being the least. Changes in leaf temperature and PRI indicated that leaf transpiration and photosynthesis were impaired by root damage. Although trees build roots in excess, mechanical damage will eventually decrease transpiration and photosynthesis across tree species.
Quantitative profiling of N-glycosylation of SARS-CoV-2 spike protein variants
Authors: Xie Yongjing , Butler Michael
Published: February 2023

With the global spread of the corona virus disease-2019 pandemic, new spike variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continuously emerge due to increased possibility of virus adaptive amino acid mutations. However, the N-glycosylation profiles of different spike variants are yet to be explored extensively, although the spike protein is heavily glycosylated and surface glycans are well-established to play key roles in viral infection and immune response. Here, we investigated quantitatively the N-glycosylation profiles of seven major emerging spike variants including Original, Alpha (B.1.1.7), Beta (B.1.351), Gamma (P.1), Kappa (B.1.671.1), Delta (B.1.671.2), and Omicron (B.1.1.529). The aim was to understand the changing pattern of N-glycan profiles in SARS-CoV-2 evolution in addition to the widely studied amino acid mutations. Different spike variants exhibit substantial variations in the relative abundance of different glycan peaks and subclasses, although no specific glycan species are exclusively present in or absent from any specific variant. Cluster analysis shows that the N-glycosylation profiles may hold the potential for SARS-CoV-2 spike variants classification. Alpha and Beta variants exhibit the closest similarity to the Original, and the Delta variant displays substantial similarity to Gamma and Kappa variants, while the Omicron variant is significantly different from its counterparts. We demonstrated that there is a quantifiable difference in N-glycosylation profiles among different spike variants. The current study and observations herein provide a valuable framework for quantitative N-glycosylation profiling of new emerging viral variants and give us a more comprehensive picture of COVID-19 evolution.