bluuebunny/crossref_metadata_2025 huggingface dataset:
Alteraciones de los niveles de las hormonas tiroideas y el síndrome metabólico
Authors: Fierro Vasco Sandy , Pacheco Toro Santiago , Vega Vasco Juan , Vega Vasco Silvana
Published: December 2020

Introducción. Más del 10 % de la población sufre alteraciones de los niveles de la hormona Tiroides sin saber que lo padece, el diagnostico se realiza con niveles bajos de hormonas tiroideas y la elevación de la TSH, esta patología es más comunes en mujeres. Tanto el hipotiroidismo como el hipertiroidismo pueden conducir a eventos cardiovasculares, arritmias e insuficiencia cardiaca.  Objetivo. Determinar el impacto de las Hormonas Tiroideas sobre los componentes lipídicos, triglicéridos y niveles de colesterol HDL, porque son parte de la definición de Síndrome Metabólico. Metodología. Una revisión bibliográfica sistemática, con información de artículos tipo metaanálisis, revisiones sistemáticas y estudio de casos y controles. Resultados. Cuando se presentan alteraciones en la función de la Hormona Tiroides pueden coexistir con el Síndrome Metabólico el mismo que es diagnosticado cuando la persona presenta tres o más de los siguientes rasgos, o toma medicamentos para controlarlos, circunferencia de la cintura mayor a 89 centímetros en mujeres y 102 centímetros en varones; Niveles elevados de triglicéridos mayor a 150 mg/dl; Colesterol de lipoproteínas de alta densidad (HDL) menos de 50 mg /dl en mujeres y 40 mg/dl en varones; Hipertensión arterial y Glucosa en ayunas elevada.   Ambos están asociados significativamente con morbilidad y mortalidad y, por lo tanto, tienen un impacto sustancial en el cuidado de la salud, en todo el mundo. Conclusión. El Hipotiroidismo Subclínico es más frecuente en mujeres y el riesgo aumenta con la edad, por lo tanto, hay que tener una mayor atención al riesgo de desarrollar Síndrome Metabólico. Así también el grupo de Hipotiroidismo Subclínico fue asociado significativamente con un mayor riesgo de desarrollar Síndrome Metabólico.
Potencial melífero de dos apiarios ubicados en los cantones Cevallos y Riobamba, Zona 3 interandina, Ecuador
Authors: Guallpa Calva Miguel Ángel , Espinoza Espinoza Armando Esteban , Caranqui Aldaz Jorge Marcelo , Guilcapi Pacheco Edmundo Danilo
Published: December 2020

Uno de los pilares para asegurar la producción apícola, es disponer de información confiable de la flora circundante y de los elementos que esta aporta al colmenar. Con ello, se puede planificar esquemas de manejo que incrementen la productividad. Frente a la necesidad de datos, se realizó el estudio de dos apiarios para contribuir al desarrollo apícola en la región interandina Zona 3, con el propósito de sustentar su gestión. Se priorizó identificar las especies vegetales de importancia melífera, y estimar su abundancia más la duración de la floración. Con la aplicación de los métodos: documental, y de campo, para el reconocimiento taxonómico de plantas melíferas, su cantidad, más el tiempo que persiste en fase de florecimiento de cada especie apícola evaluada, y la sistematización de los datos recopilados. Para el área del apiario A, se reporta 38 especies vegetales pertenecientes a 22 familias botánicas, siendo las más representativas: Asteraceae con 7 especies, y Rosaceae con 5. Por su parte, en el área del colmenar B, se registró 64 especies vegetales, correspondientes a 30 familias botánicas en las que se distingue la familia Fabaceae con 15 especies, y Asteraceae con 6. En abundancia para el apiario domina la especie Raphanus spp., en la subárea de rastrojos con más de 10000 individuos con flores, seguida por Prunus persica con 1000 a 10000 individuos con flores formando parte de la subárea de cultivos frutícolas y en el caso del apiario B, se destaca Raphanus spp con más de 10000 individuos con flores que predominan en la subárea de cultivos, y con menos de 1000 individuos en floridez para el resto de los especímenes. Cuya duración del florecimiento brinda una oferta parcialmente continua de recursos florales entre tres a seis meses, a excepción del área de pastos.
Uso do ozônio para otimizar o reparo tecidual após complicações em cirurgia oral: relato de caso
Authors: Sol Izabella , Silva Rachel de Freitas , Rodrigues Cristóvão Marcondes de Castro , Silva Cláudia Jordão , Rocha Flaviana Soares
Published: December 2020

A ozonioterapia tem sido utilizada como terapia adjuvante em múltiplas modalidades terapêuticas na odontologia. Caracterizado por poucos efeitos adversos em doses terapêuticas, o ozônio está associado à formação de moléculas reativas de oxigênio que influenciam o metabolismo celular e desencadeiam uma resposta antioxidante, favorecendo o reparo tecidual, além de possuir efeito antimicrobiano. Diversos estudos comprovam os benefícios do ozônio para área da saúde. O objetivo deste trabalho é relatar o benefício de uso do ozônio para auxílio de regeneração de tecido gengival avulsionado de forma traumática após a realização de uma exodontia de terceiro molar inferior, onde foi instituído como tratamento a irrigação de água ozonizada em concentração de 8µg/ml e aplicação de gás ozônio por um período de quatro semanas. Após acompanhamento por 14 meses, o tecido gengival se apresentava sem sinais de isquemia, necrose e infecção, com reparo total da área acometida.
Estratégia para tratamento de rânula mergulhante. Relato de caso
Authors: Jesus Laís Kawamata de , Hadad Henrique , Silva Raquel Barroso Parra da , Santos Ana Flávia Piquera , Colombo Luara Teixeira , Gonçalves Paulo Zupelari , Ferreira Sabrina , Matsumoto Mariza Akemi , Fabris André Luís da Silva , Bassi Ana Paula Farnezi , Faverani Leonardo Perez , Magro Filho Osvaldo , Garcia Júnior Idelmo Rangel , Souza Francisley Ávila
Published: December 2020

Rânula é definida como um pseudocisto originada do extravasamento de líquido mucinoide da glândula sublingual, frequentemente associado a trauma ou obstrução do ducto da glândula. Clinicamente, caracterizada por uma coloração azulada, translúcida localizada no assoalho bucal e pode ser classificada como rânula intraoral ou mergulhante. O diagnóstico inclui exame clínico detalhado e exames de imagens combinados com achados histopatológicos. Abordagens terapêuticas podem ser aplicados para tratamento esta lesão, como marsupialização, exérese da rânula associada ou não a glândula sublingual e exérese da rânula juntamente a glândula sublingual e submandibular. O objetivo deste artigo foi relatar um caso de rânula mergulhante, tratada por exérese seguida de marsupialização da lesão cística, após um ano de acompanhamento com recidiva. Concluímos que um tratamento menos invasivo pode não apresentar a melhor estratégia para o tratamento de rânula mergulhante, devido as maiores chances de recidiva.
Estabilidade de agregados de um ArgissoloVermelho-Amarelo determinado por diferentes metodologias
Authors: Araújo Lourismar Martins , Nunes Maria Cândida Moitinho , Marostega Thalita Neves , Andrade Fabrício Ribeiro , Lanssanova Luciano Rodrigo , Ferreira Kleyton Rezende , Gil Rodrigo Lemos
Published: December 2020

O conhecimento da estabilidade dos agregados dos solos da região de Cáceres, situados no entorno do Pantanal, Cerrado e Floresta amazônica, pode auxiliar na tomada de decisões sobre o manejo adequado do solo nestas áreas. Esse trabalho objetivou determinar a estabilidade de agregados do solo por diferentes metodologias de peneiramento úmido, em Argissolo Vemelho-Amarelo Eutrófico chernossólico sob mata nativa na camada de 0-10 cm. Foi avaliado a distribuição de agregados em classe de diâmetro, DMP e teor de agregados. Não houve diferença significativa entre os métodos para a distribuição de agregados em classe de diâmetro, no entanto foi significativa entre as classes, a classe de 9,51-4,7 mm apresentou maior percentagem de agregados em todos os tratamentos. Não houve diferença significativa entre os tratamentos para o DMP. Para o Teor de Agregados houve um predomínio dos agregados maiores que 2 mm (63,22%). De maneira geral o solo avaliado pode ser considerado um solo com alta estabilidade de agregados.
Chemical profile and potential antifungal of essential oil Schinus terebinthifolius and its by-products
Authors: Oliveira Júnior Luiz Fernando Ganassali de , Oliveira Alexandre Passos , Fontes Pryanka Thuyra Nascimento , Oliveira Lucas Fonseca Menezes de , Santos Marília Cavalcante , Gagliardi Paulo Roberto , Carnelossi Marcelo Augusto Gutierrez
Published: December 2020

This study aimed to investigate the distillation time to obtain a higher yield of essential oil and by-product (extract and hydrolate) of Schinus terebinthifolius seeds, to determine the main chemical constituents of these products and the potential fungitoxic on the Colletotrichum gloeosporioides. To obtain the essential oil and by-products, we used the method of steam distillation for 2.5, 4.0, 5.5 and 7.0 hours. The determination of the chemical composition was made by GC/MS. To determine the potential fungitoxic on mycelial growth of C. gloeosporioides various concentrations of the oil and by-products were tested. Distillation periods did not influence the yield of aqueous extract and essential oil hydrolate. No chemical compounds have been identified in hydrolat or aqueous extract with the use of GC analysis. The essential oil at concentrations of 2%, 3% and 4% inhibited approximately 47% of the in vitro development of the fungus C. gloeosporioides.
Um levantamento sobre a produção do conhecimento em financiamento da educação infantil
Authors: Santos Joedson Brito dos
Published: December 2020

O presente artigo é parte de um estudo de estágio pós-doutoral e tem como objetivo inventariar a produção científica sobre o financiamento da educação infantil (EI), no Brasil, entre os anos de 1989 a 2019, considerando aspectos que indiquem a trajetória das pesquisas e os principais temas investigados. Trata-se de uma pesquisa bibliográfica e documental que reuniu teses, dissertações, livros, capítulos de livros e artigos. Utilizou-se como fonte de dados o Banco de Teses e Dissertações da Capes, a Plataforma SciELO, Google Scholar, a revista da Fineduca e o currículo Lattes dos pesquisadores da rede Fineduca. Conclui-se que os estudos sobre o financiamento da EI têm aumentado a partir do contexto de transição do Fundef para o Fundeb, principalmente, no pós Fundeb, mas ainda é incipiente com apenas 8 trabalhos de teses, o que sugere que o campo da pesquisa precisa se consolidar. Os eixos temáticos com maior número de publicação foram: Política de financiamento da EI e expansão do atendimento; Financiamento da EI e a relação público-privado e os estudos sobre Financiamento da EI e as Políticas de Fundo. Espera-se que o presente estudo possa contribuir com uma visão geral da produção sobre o tema, apontar aspectos poucos explorados, auxiliar o trabalho de futuros pesquisadores, bem como promover o fortalecimento dos estudos sobre o direcionamento dos recursos públicos para EI.
Identificação e análise de Garbage code ocorridos no preenchimento da Declaração de Óbito no Hospital Geral de Nova Iguaçu - RJ, uma realidade a ser modificada
Authors: Amaral Rian Thiele do , Soares Roselene de Fátima Semedo , Silva Silvana Maria Tabosa Carvalho da , Neves Milena Preissler das , Silva Leandro Andrade da , Silva Roni Robson da
Published: December 2020

A declaração de óbito é de suma importância no âmbito de saúde pública, sendo utilizado como ferramenta para traçar indicadores epidemiológicos para futuras políticas de saúde preventivas. Objetivo: identificar os principais erros e/ou inconsistência de informações, Código Garbage (CG), pertencente ao CID-10 nos preenchimentos das declarações de óbito do Hospital Geral de Nova Iguaçu. Método: trata-se de um trabalho científico exploratório, que tem como base a busca de informações através Sistema de Informação sobre Mortalidade (SIM) do Departamento de Informática do Sistema Único de Saúde (DATASUS), revisão bibliográfica e pesquisa de campo. Resultado: o número de casos CG produzidos em Nova Iguaçu foi de 3058 casos, dentre esses, 1963 foram produzidos no Hospital Geral de Nova Iguaçu. Conclusão: Este estudo aponta a importância de implementar medidas, como palestras de educação continuada e valorização da importância da declaração de óbito, a fim de minimizar a quantidade de CG e oportunizar maior confiabilidade ao SIM, sendo esse uma importante ferramenta para estatísticas epidemiológicas e planejamento das políticas públicas de saúde preventiva.
Effectiveness of a simulation activity on knowledge about glucose monitoring and hypoglycemia management: a pre-post intervention study
Authors: Souza Thais Lima Vieira de , Moreira Tatiana Rebouças , Araújo Samila Torquato , Negreiros Francisca Diana da Silva , Silva Lucilane Maria Sales da , Moreira Thereza Maria Magalhães , Aquino Maria de Jesus Nascimento de , Ferreira Marília Araripe , Viana Júnior Antonio Brazil , Fernandes Virgínia Oliveira , Montenegro Júnior Renan Magalhães
Published: December 2020

Adequate management of diabetes requires professional improvement programs. This study aimed to analyze the effect of a simulation activity on the acquisition of knowledge about blood glucose monitoring and hypoglycemia management. The study employed a pre-post intervention approach and was carried out in a university hospital located in Brazil. The participants were 82 graduating nursing students and nursing professionals studying/working at the university hospital. The intervention consisted of theoretical sessions, a practical simulation about glycemic monitoring and hypoglycemia management, and the pre- and post-tests. The simulation consisted of a rubber hand mannequin that allows simulating the glucose testing. There was a significant increase in knowledge after intervention with the total number of correct answers increasing from 186 in the pre-test to 326 in the post-test (+140, p < .001). The intervention was effective in increasing the participants' knowledge about glycemic monitoring and hypoglycemia management, favoring a better nursing care for people with diabetes.
Práticas interdisciplinares de cuidado por meio de uma residência multiprofissional em diabetes
Authors: Moreira Tatiana Rebouças , Negreiros Francisca Diana da Silva , Silva Lucilane Maria Sales da , Moreira Thereza Maria Magalhães , Carvalho Silvana Linhares de , Aquino Maria de Jesus Nascimento de , Araújo Samila Torquato , Montenegro Júnior Renan Magalhães
Published: December 2020

O presente estudo descreve práticas interdisciplinares de cuidado desenvolvidas em uma residência multiprofissional em diabetes. Trata-se de estudo descritivo realizado em um Serviço de Endocrinologia e Diabetes. A coleta de dados ocorreu no período de setembro a dezembro de 2020, por meio de formulário semi-estruturado e observação direta. A amostra foi composta por 16  profissionais da área da saúde e de apoio. Os dados foram analisados de forma descritiva. Os resultados mostram que a residência multiprofissional em diabetes é uma formação permanente em saúde, promissora e inovadora, que busca agregar a teoria e a prática durante o exercício das atividades em serviço e possibilita o compartilhamento de informações na equipe multiprofissional, gerando condutas interdisciplinares, integradas e holísiticas. Desse modo, conclui-se que as práticas interdisciplinares de cuidado possibilitam, além de uma formação específica, a ampliação da assistência especializada em diabetes nos três níveis de atenção à saúde, subsidiando melhorias na qualidade de vida dos pacientes e a formação de profissionais qualificados para o mercado de trabalho.
Vírus da imunodeficiência adquirida: o conhecimento da infecção pelos adolescentes
Authors: Soares Felipe Costa , Rocha Paula Sousa da Silva , Peixoto Osvaldo da Silva , Bandeira Francisco Jadson da Silva , Pamplona Mônica Custódia do Couto Abreu , Santos Edenilza Fabiana de Almeida , Carvalho Dayara de Nazaré Rosa de , Vasconcelos Lidiane Assunção de , Vasconcelos Maria Eduarda dos Santos Lopes , Nobre Ana Laura Nobre e , Verçosa Marucia  Fernandes , Barros Hyslla Maria de Oliveira , Gaspar Sâmia  Rebeca da Silva , Silva Adrienne Sofia Pereira da , Silva Larissa Pantoja , Rocha Marcela Fernanda dos Santos , Freitas Amélia Caroline Ribeiro de , Souza Regina Coeli Nascimento de , Peixoto Ivonete Vieira Pereira
Published: December 2020

A adolescência é um período compreendido entre a idade de 10 a 20 anos, de acordo com a Organização Mundial da Saúde. Com exercício da sexualidade, o início da atividade sexual precoce entre os adolescentes traz grandes implicações, chegando a se tornar um problema de saúde pública. O objetivo deste estudo foi investigar através de Revisão Integrativa da Literatura (RIL) o grau de conhecimento dos adolescentes em relação às IST/AIDS. Para a análise utilizou-se artigos publicados em bases de dados eletrônicos dos últimos 10 anos, fornecendo informações importantes sobre a temática. Os achados revelaram que os adolescentes têm conhecimento em relação a imunodeficiência adquirida (HIV/AIDS) assim como suas medidas de prevenção, porém ainda é um grupo considerado vulnerável para esta e outras infecções sexualmente transmissíveis, sendo necessário avançar ações de promoção a saúde, uma vez que a taxa de infecção ainda é grande entre o grupo. Dessa forma, o desenvolvimento de políticas públicas que promovam ações de promoção e prevenção à saúde são de extrema relevância para a redução desses indicadores e para a melhoria da qualidade de vida deste grupo.
Hierarchical Flow Among Four Shipping Markets: An Integrated Approach for Capesize Shipping Markets
Authors: AÇIK Abdullah
Published: December 2020

Although there are theoretical researches on the interactions between four shipping sub-markets, empirical studies examining four to cover are rare. Also, market interactions may differ in positive or negative environments. Accordingly, the purpose of this study is to examine the hierarchical structure among the 4 sub-maritime markets by providing a methodological proposition. This study integrates the Interpretive Structural Modelling (ISM) method with the asymmetric causality analysis and examines the hierarchical structure between the four markets in terms of positive and negative shocks through the Capesize markets. The dataset used in the study covers the period between 07.01.2013 - 18.07.2019 and consists of 342 weekly observations. The results show that the hierarchical flow of positive and negative shocks differs in the Capesize market. In terms of positive shocks, the demolition market stands out as the starting point of the shocks, while in terms of negative shocks, freight and new building markets come to the fore. Our study reveals hierarchical structures for maritime markets by testing their relationships empirically and contributes to the maritime literature where the freight market is theoretically considered a pioneer. A new methodical perspective is thought to be presented to the maritime economics literature.
IMPACT OF DOWNSTREAM POTENTIAL PERTURBATIONS ON THE NONLINEAR STABILITY OF A GENERIC FAN
Authors: Romera David , Corral Roque
Published: December 2020

The dependence of the aerodynamic stability of fan blades with amplitude and nodal diameter of potential perturbations associated with the presence of pylons is studied. The analysis is conducted using a novel block-wise spatial Fourier decomposition of the reduced-passages to reconstruct the full-annulus solution. The method represents very efficiently unsteady flows generated by outlet static pressure non-uniformities. The explicit spatial Fourier approximation is exploited to characterize the relevance of each nodal diameter of outlet perturbations in the fan stall process, and its nonlinear stability is studied in a harmonic by harmonic basis filtering the nonlinear contribution of the rest. The methodology has been assessed for the NASA rotor 67. The maximum amplitude of the downstream perturbation at which the compressor becomes unstable and triggers a stall process has been mapped. It is concluded that the fan stability dependence with the amplitude of the perturbation is weaker than in the case of intake distortion. For perturbations with an odd number of nodal diameters, the nonlinear stability analysis leads to the same conclusions as to the small amplitude linear stability analysis. However, if the perturbations have an even number nodal diameters, the flow exhibits a supercritical bifurcation and have a stabilizing effect.
Modeling the Relationships among Mastery Goal Orientations, Positive Coping Strategy, and Motivational Beliefs in Science
Authors:   Department of Mathematics and Science Education, Hatay Mustafa Kemal University, Faculty of Education, Hatay, Turkey, Subaşi Münevver
Published: December 2020

This study aimed to investigate the relationships among mastery goal orientations (approach and avoidance), adaptive coping strategy (positive coping), and motivational beliefs (self-efficacy and task value) among middle school students in science. The study group consists of 249 students studying at four middle schools in one of the largest cities located in the eastern part of Turkey. The research data were collected using Achievement Goals Questionnaire, Academic Coping Inventory, and the Motivated Strategies for Learning Questionnaire. Structural equation modeling was performed using AMOS program to test the hypothesized relationships among constructs. The results showed that individuals with mastery goal orientation used more positive coping strategies. It was observed that individuals with higher self-efficacy had a higher ratio of using positive coping strategies. In addition, individuals with a high level of motivational beliefs used more mastery goal orientation. Furthermore, while mastery goal orientations positively predicted motivational beliefs and positive coping strategies, positive coping strategy was found to predict positively self-efficacy only. This study was a correlational study, but correlational studies did not help the establishment of a cause-effect (causality) relationship between the variables in question. Experimental studies can be conducted in the future to reveal the causes and effects related to the correlation between the relevant variables.
Assessing teachers' competencies in identifying aspects of nature of science in educational critical scenarios
Authors:   Department of Mathematics and Science Education, Ataturk Faculty of Education, Marmara University, Istanbul, Turkey, Irez Serhat , Han-Tosunoglu Cigdem ,   Department of Mathematics and Science Education, Ataturk Faculty of Education, Marmara University, Istanbul, Turkey, Dogan Nihal ,   Department of Mathematics and Science Education, Faculty of Education, Bolu Abant Izzet Baysal University, Bolu, Turkey,, Cakmakci Gultekin ,   Department of Mathematics and Science Education, Faculty of Education, Hacettepe University, Ankara, Turkey, Yalaki Yalcin ,   Department of Elementary Education, Faculty of Education, Hacettepe University, Ankara, Turkey, Erdas-Kartal Eda ,   Department of Educational Sciences, Faculty of Education, Kastamonu University, Kastamonu, Turkey
Published: December 2020

Many scholars and science curricula from around the world describe socioscientific issues (SSIs) as meaningful contexts for teaching about the nature of science (NOS). These calls are guided by the assumption that science teachers are able to identify relevant aspects of the NOS in a given SSI and to decide how to utilize these for NOS instruction. To this end, this study aimed to assess a group of science teachers’ competencies in identifying aspects of the NOS in various educational critical scenarios (ECS) featuring different SSI. 15 science teachers’ understandings of the NOS were assessed through interviews and their competence in identifying aspects of the NOS in given ECSs was addressed through an open-ended questionnaire. The results indicated that, although all of the participants had informed views regarding the majority of the aspects of the NOS, the majority of them failed to transfer this knowledge and could not exhibit similar competence in identifying some aspects of NOS in ECSs. This implies that having an informed understanding of the NOS does not guarantee effective translation of this understanding into the classrooms.
Enhancing Pre-service Teachers’ Reflective Quality on Inquiry-based Teaching Through a Community of Practice
Authors:   Faculty of Education, Kasetsart University, Bangkok, Thailand, Ketsing Jeerawan , Inoue Noriyuki ,   Faculty of Human Sciences, Waseda University, Tokyo, Japan, Buczynski Sandy ,   School of Leadership and Education Sciences, University of San Diego, CA, United States
Published: December 2020

Implementing inquiry-based teaching in secondary school is often a challenge for pre-service teachers. Thoughtful reflection on their teaching experience may help future teachers address this challenge. This article examined the quality of reflection on inquiry teaching by two pre-service science teachers as they participated in a mini-Community of Practice (mCoP) with their cooperating teachers and university advisor. Findings from this study revealed the benefits of this mCoP for nurturing pre-service teachers’ inquiry teaching by building a network of encouraging support from experienced teachers and by providing a supportive reflective environment. The study also showed pre-service teachers transformed their reflections from technical to reflective thinking as they matured in inquiry-based teaching practice.
Card Game-based Learning on Nutrition Value and Labeling
Authors:   Department of Biology, Chemistry and Home Economics, Faculty of Education, University of Ljubljana, Ljubljana, Slovenia, Damjana Lampe , Kozina Francka Lovšin ,   Department of Biology, Chemistry and Home Economics, FacuDepartment of Biology, Chemistry and Home Economics, Faculty of Education, University of Ljubljana, Ljubljana, Slovenia
Published: December 2020

In a consumer society, educating children for a healthy lifestyle is challenging for the teacher. Daily, children are exposed to large amounts of information (including misinformation) and the field of healthy eating is no exception. The teacher must, therefore, develop good teaching strategies that include informative/innovative teaching tools. The aim of the study was to determine whether the learning results of pupils after the introduction of a didactic game with nutrition cards were better than the learning results of pupils who acquired knowledge through a traditional (teacher-lead) presentation. This pedagogical experiment was conducted with 56 Slovenian Grade 6 pupils aged 11–12 (28 students in the experimental group [EG] and 28 in the control group [CG]). The results showed that the EG students (students learning with nutritional cards) achieved a better result in the knowledge test compared to CG students. Most pupils taught with nutrition cards expressed a positive opinion about this type of learning. They also stated that they would pay more attention to nutrition labeling in future purchases. The results suggest that using nutritional cards in teaching can have a positive effect on the learning process and the learning outcome.
The Use of Critical Reading in Understanding Scientific Texts on Academic Performance and Problem-solving Skills
Authors:   Department of Mathematics and Science Education, Ereğli Education Faculty, Zonguldak Bulent Ecevit University, Kdz. Ereğli, Zonguldak, Koray Özlem , Çetinkılıç Sercan ,   15 Temmuz Şehitleri İmam Hatip Secondary School, Kdz. Ereğli, Zonguldak
Published: December 2020

This study aimed to investigate the effect of critical reading (CR) practices in science courses on academic achievement, science performance level, and problem-solving skills. The experimental method and factorial design were used. The study was conducted with 102 seventh-grade students from a public school in Turkey during the 2014–2015 academic year. Experimental and control groups were formed. CR practices were followed in the experimental group and teaching practices appropriate to the curriculum were used in the control group. Data were collected with the “Multiple-Choice Academic Achievement Test” to determine the students’ academic level in the “Human and Environment Unit: The Science Performance Level Test” to determine their science performance level and the “Logical Thinking Group Test” to determine the level of their problem-solving skills. The variables of academic achievement and science performance levels were labeled “Academic Performance.” Independent samples two-way ANOVA was applied to analyze the data using SPSS 18.0 software. The results revealed that the students in the experimental group, who were taught science using CR practices, were significantly more successful than the students in the control group, whose teaching was appropriate to the current curriculum in terms of academic achievement, science performance level, and problem-solving skills. It is of critical importance to use such innovative practices, which combine various disciplines, to allow students to excel at reading, which is a basic skill, at all educational levels in order to raise contemporary and social individuals.
Effect of Pressures and Durations of Cupping Therapy on Skin Blood Flow Responses
Authors: Wang Xiaoling , Zhang Xueyan , Elliott Jeannette , Liao Fuyuan , Tao Jing , Jan Yih-Kuen
Published: December 2020

Cupping therapy has been widely used in treating musculoskeletal impairments. However, there is no specific guideline on selecting the intensity of cupping therapy, including the pressure and duration. The objective of this study was to investigate the effect of different pressures and durations of cupping therapy on skin blood flow responses. A 2 × 2 factorial design, including two negative pressures at −225 and −300 mmHg and two durations at 5 and 10 min, was tested in 12 healthy participants. The four protocols of cupping therapy were tested in four different days. Skin blood flow was measured using laser Doppler flowmetry on the left triceps (the SJ12 acupoint). Skin blood flow after cupping therapy was expressed as a ratio of skin blood flow before cupping therapy. The results showed that −300 mmHg caused a significant increase in peak skin blood flow (16.7 ± 2.6 times) compared to −225 mmHg (11.1 ± 2.2 times, p < 0.05) under 5-min duration. The largest difference in skin blood flow is between −300 mmHg for 5 min (16.7 ± 2.6 times) and −225 mmHg for 10 min (8.1 ± 2.3 times, p < 0.01). Our findings demonstrated that a higher value (300 mmHg) of negative pressure is more effective on increasing skin blood flow compared to a lower value (225 mmHg). Also, a shorter duration (5 min) causes a larger peak and total skin blood flow compared to a longer duration (10 min). This study provides the first evidence showing the effect of pressures and durations of cupping therapy on skin blood flow responses.
Identification of Small Molecule Inhibitors of the Deubiquitinating Activity of the SARS-CoV-2 Papain-Like Protease: in silico Molecular Docking Studies and in vitro Enzymatic Activity Assay
Authors: Pitsillou Eleni , Liang Julia , Ververis Katherine , Lim Kah Wai , Hung Andrew , Karagiannis Tom C.
Published: December 2020

COVID-19 is an ongoing pandemic caused by the SARS-CoV-2 virus with important political, socio-economic, and public health consequences. Inhibiting replication represents an important antiviral approach, and in this context two viral proteases, the SARS-CoV-2 main and papain-like proteases (PLpro), which cleave pp1a and pp1ab polypeptides, are critical. Along with protease activity, the PLpropossesses deubiquitinating activity, which is important in immune regulation. Naphthalene-based inhibitors, such as the well-investigated GRL-0617 compound, have been shown to possess dual effects, inhibiting both protease and deubiquitinating activity of the PLpro. Rather than binding to the canonical catalytic triad, these type of non-covalent inhibitors target an adjacent pocket, the naphthalene-inhibitor binding site. Using a high-throughput screen, we have previously identified the dietary hypericin, rutin, and cyanidin-3-O-glucoside compounds as potential protease inhibitors targeting the naphthalene-inhibitor binding site. Here, our aim was to investigate the binding characteristics of these compounds to the PLpro, and to evaluate deubiquitinating activity, by analyzing seven different PLprocrystal structures. Molecular docking highlighted the relatively high affinity of GRL-0617 and dietary compounds. In contrast binding of the small molecules was abolished in the presence of ubiquitin in the palm subdomain of the PLpro. Further, docking the small molecules in the naphthalene-inhibitor binding site, followed by protein-protein docking revealed displacement of ubiquitin in a conformation inconsistent with functional activity. Finally, the deubiquitinating activity was validatedin vitrousing an enzymatic activity assay. The findings indicated that the dietary compounds inhibited deubiquitinase activity in the micromolar range with an order of activity of GRL-0167, hypericin >> rutin, cyanidin-3-O-glucoside > epigallocatechin gallate, epicatechin gallate, and cefotaxime. Our findings are in accordance with mechanisms and potential antiviral effects of the naphthalene-based, GRL-0617 inhibitor, which is currently progressing in preclinical trials. Further, our findings indicate that in particular hypericin, rutin, and cyanidin-3-O-glucoside, represent suitable candidates for subsequent evaluation as PLproinhibitors.
Research in Education Draws Widely From the Social Sciences and Humanities
Authors: Lund Kristine , Jeong Heisawn , Grauwin Sebastian , Jensen Pablo
Published: December 2020

It is well-known that education related research is carried out within different disciplines and frameworks, but how is it specifically connected through citations to the larger social sciences and humanities? And how can this knowledge be mobilized to improve dialogue between researchers in different communities, given the benefits of integrating different frameworks and methods? We used different scientometric methods to show where exactly research in education connects to social sciences and humanities. This multidisciplinary context provokes a set of integration challenges for research in education. We propose how our work can supplement an existing model in order to give a framework for meeting these challenges with the goal of achieving broader education-related collective knowledge advancement.
Identification of Key Lines for Multi-Photovoltaic Power System Based on Improved PageRank Algorithm
Authors: Feng Hao , Li Sheng , Li Huaisen
Published: December 2020

In order to accurately identify the key lines in the photovoltaic (PV) grid-connected system, an identification method based on the improved PageRank algorithm is proposed. Firstly, the correlation matrix reflecting the electrical characteristics of the system is constructed using the line current-carrying rate, line breaking power flow transfer rate and line coupling rate, to replace the original network topology matrix. Secondly, through the entropy method, a comprehensive evaluation index based on electrical betweenness, load deviation rate and voltage shock rate is constructed to improve the distribution of the initial PageRank (PR) value of the PV grid-connected system. To study the changes’ impact of PVs active power outputs on the identification results of key lines in the Multi-PV power system, the HGWO-SVM (Hybrid Grey Wolves Optimized Support Vector Machine) algorithm was used to obtain the PVs daily outputs prediction curves and obtain fixed outputs of PVs at different periods, so as to study the impact of the variation of PV daily output on the key line identification. Taking the IEEE 39-node system containing multi-PV as an example, the identification results show that the improved PageRank algorithm is superior to the original method in line identification accuracy. The HGWO-SVM algorithm by adaptively modifying the cross operator and mutation operator also has a certain improvement in prediction accuracy. The changes of PVs daily outputs have different degree of influence on the line criticality (namely final PR value) during periods of high light intensity and other periods of light intensity.
Analysis of Pan-omics Data in Human Interactome Network (APODHIN)
Authors: Biswas Nupur , Kumar Krishna , Bose Sarpita , Bera Raisa , Chakrabarti Saikat
Published: December 2020

Analysis of Pan-omics Data in Human Interactome Network (APODHIN) is a platform for integrative analysis of transcriptomics, proteomics, genomics, and metabolomics data for identification of key molecular players and their interconnections exemplified in cancer scenario. APODHIN works on a meta-interactome network consisting of human protein–protein interactions (PPIs), miRNA-target gene regulatory interactions, and transcription factor-target gene regulatory relationships. In its first module, APODHIN maps proteins/genes/miRNAs from different omics data in its meta-interactome network and extracts the network of biomolecules that are differentially altered in the given scenario. Using this context specific, filtered interaction network, APODHIN identifies topologically important nodes (TINs) implementing graph theory based network topology analysis and further justifies their role via pathway and disease marker mapping. These TINs could be used as prospective diagnostic and/or prognostic biomarkers and/or potential therapeutic targets. In its second module, APODHIN attempts to identify cross pathway regulatory and PPI links connecting signaling proteins, transcription factors (TFs), and miRNAs to metabolic enzymes via utilization of single-omics and/or pan-omics data and implementation of mathematical modeling. Interconnections between regulatory components such as signaling proteins/TFs/miRNAs and metabolic pathways need to be elucidated more elaborately in order to understand the role of oncogene and tumor suppressors in regulation of metabolic reprogramming during cancer. APODHIN platform contains a web server component where users can upload single/multi omics data to identify TINs and cross-pathway links. Tabular, graphical and 3D network representations of the identified TINs and cross-pathway links are provided for better appreciation. Additionally, this platform also provides few example data analysis of cancer specific, single and/or multi omics dataset for cervical, ovarian, and breast cancers where meta-interactome networks, TINs, and cross-pathway links are provided. APODHIN platform is freely available at http://www.hpppi.iicb.res.in/APODHIN/home.html.
Women's Mental Health in the Time of Covid-19 Pandemic
Authors: Thibaut Florence , van Wijngaarden-Cremers Patricia J. M.
Published: December 2020

Even if the fatality rate has been twice higher for men than for women, the Covid-19 pandemic has affected women more than men, both as frontline workers and at home. The aim of our article was to analyze the differences observed in mental health and violence between men and women in the COVID outbreak. For this purpose, we have used all papers available in PubMed between January and July 2020 as well as data from non-governmental associations. We have thus successively analyzed the situation of pregnancy during the pandemic; the specific psychological and psychiatric risks faced by women both as patients and as workers in the health sector, the increased risk of violence against women at home and at workplace and, finally the risk run by children within their families. In conclusion, research on the subject of mental health issues during the Covid-19 pandemic is still scarce, especially in women. We hope that this pandemic will help to recognize the major role of women at home and at the workplace.
Change of Serum Metabolome and Cecal Microflora in Broiler Chickens Supplemented With Grape Seed Extracts
Authors: Cao Guangtian , Zeng Xinfu , Liu Jinsong , Yan Feifei , Xiang Zhentian , Wang Yongxia , Tao Fei , Yang Caimei
Published: December 2020

Grape seed is rich in vitamin E, flavonoids, and proanthocyanidins and has the potential to be used as an antibiotic substitute in broilers. We investigated the effects of grape seed proanthocyanidin extract (GSPE) on growth performance, immune responses, cecal microflora, and serum metabolism in early stage broilers. Data indicated that GSPE improved broiler growth performance by strengthening antioxidant capacity, enhancing immune responses, and increasing cecal short chain fatty acids. 16S rRNA sequencing indicated that GSPE changed the predominant cecal microflora and induced the metabolism of amino acids, lipids, and carbohydrates. An UPLC-Q-TOF/MS-based metabolomics analysis identified 23 serum metabolites (mainly related to lipid, amino acid, and alkaloid) were extremely changed by GSPE treatment. The correlations between the changes of cecal microflora and serum metabolites in birds fed with GSPE were analyzed. Hence, GSPE potentially provides active ingredients that may be used as antibiotic substitute and reduces environmental pollution by grape by-products.
The Role of Manipulating Photoperiod and Temperature in Oocyte Development of the Polychaete Hediste diversicolor (O.F. Müller, 1976)
Authors: Wang Haiqing , Hagemann Andreas , Malzahn Arne M. , Handå Aleksander , Uhre Marianne , Kjørsvik Elin , Reitan Kjell Inge
Published: December 2020

Three different experiments were conducted to examine the oocyte development of the polychaete Hediste diversicolor in response to changing photoperiod and temperature at three different periods of oogenesis. In experiment I, worms collected during summer were reared under constant or decreasing photoperiod and temperatures to test the combined effects of the summer–autumn photoperiod and temperature transition on oogenesis. The result showed females collected during summer showed the highest oocyte growth when exposed to constant temperatures combined with decreasing photoperiod and decreasing temperature combined with constant photoperiod. In experiment II, worms collected in late autumn were under mimicked or shortened seasonal changes in photoperiod to evaluate the effect of accelerated change on oocyte growth. The result showed worms had 1.5 times faster oocyte growth rates when exposed to accelerated rate of change in photoperiod (2.5 times faster). In experiment III, worms collected in spring were exposed to different temperature regimes to examine the effect of raising temperature on the synchronization of oocyte growth and maturation. The results showed worms collected in spring showed increased temperatures will increase oocyte maturation synchronicity. It was concluded temperature and photoperiod transition can increase the oocyte development.
Novel Contributions to the Taxonomy of the Ciliates Genus Euplotes (Ciliophora, Euplotida): Redescription of Two Poorly Known Species, With a Brief Note on the Distributions of This Genus in Coastal Waters of Southern China
Authors: Liu Weiwei , Jiang Jiamei , Tan Yehui , Lin Xiaofeng
Published: December 2020

As the typical periphytic ciliate, the genus Euplotes Ehrenberg, 1830 is highly diversified and commonly observed in marine water. In this study, the living morphology, infraciliature and silverline system of two poorly known Euplotes species, E. neapolitanusWichterman, 1964 and E. antarcticusFenchel and Lee, 1972, isolated from coastal water of southern China, were investigated. The original description of these two species were brief, and thus we provided detailed redescription based on our Chinese population. Their diagnoses were improved by adding some morphology characteristics and their detailed illustrations and photomicrographs were first supplied here. Based on the sufficient justification for identification of our population by morphology, their small subunit ribosomal RNA gene sequences which have been reported were linked to the accurate species name. Phylogenetic analyses showed that these two species cluster with their congeners which shared high morphological similarities with them. In addition, the geographic distribution of the genus Euplotes in coast of southern China was revealed, and the mangrove was considered as the ideal habitat for them by possessing the higher species richness.
Six Recommendations to Build Legitimacy for Translational Research Organizations
Authors: Rosser Christian , Sager Fritz , Leib Stephen L.
Published: December 2020

Translational research organizations (TROs) face specific challenges to secure resilience and longevity. This perspective article provides the rationale for six hands-on recommendations for the management of legitimacy building in TROs.
Some Questions to Our Chinese Colleagues Pioneering Research Into Coronavirus Disease 2019 (COVID-19)
Authors: Stöllberger Claudia , Winkler-Dworak Maria
Published: December 2020

A pandemic has developed, so physicians worldwide are particularly interested in the experiences of their Chinese Colleagues which are frequently cited. To assess the long-term pulmonary, cardiac, neurologic, and psychiatric consequences after COVID-19, the outcome of patients included in the early publications and the association with baseline findings is of particular interest. Thus, we review the methods of early Coronavirus disease 2019 (COVID-19) publications. Reports published before March 19th 2020, comprising >40 patients were included, considering especially cardiologic aspects. It remains unclear whether patients were described several times, or they were different patients. Only patients with confirmed COVID-19 were described, and no differences in findings of patients with initially suspected and later confirmed, or excluded infection. It remains unclear in how many cases information was missing, since missing values were not reported. Medication before hospital admission, level of education and occupation, household size and composition, weight or body mass index are lacking. No details about electrocardiographic findings are given. Patients still in follow-up, constituting the major part of observations, were excluded. The data should be re-analyzed. A comparison between confirmed and excluded cases could be carried out. By now, in November 2020, the reported patients will most probably have recovered. Thus, it would be possible to differentiate prognostic indicators more precisely. Laboratory tests and electrocardiograms could be analyzed in more detail to shed light on the spectrum of this disease and to solve some of the unanswered questions related with COVID-19.