bluuebunny/crossref_metadata_2025 huggingface dataset:
Model Combining Tumor Molecular and Clinicopathologic Risk Factors Predicts Sentinel Lymph Node Metastasis in Primary Cutaneous Melanoma
Authors: Bellomo Domenico , Arias-Mejias Suzette M. , Ramana Chandru , Heim Joel B. , Quattrocchi Enrica , Sominidi-Damodaran Sindhuja , Bridges Alina G. , Lehman Julia S. , Hieken Tina J. , Jakub James W. , Pittelkow Mark R. , DiCaudo David J. , Pockaj Barbara A. , Sluzevich Jason C. , Cappel Mark A. , Bagaria Sanjay P. , Perniciaro Charles , Tjien-Fooh Félicia J. , van Vliet Martin H. , Dwarkasing Jvalini , Meves Alexander
Published: April 2020

PURPOSE

More than 80% of patients who undergo sentinel lymph node (SLN) biopsy have no nodal metastasis. Here, we describe a model that combines clinicopathologic and molecular variables to identify patients with thin- and intermediate-thickness melanomas who may forgo the SLN biopsy procedure because of their low risk of nodal metastasis.

PATIENTS AND METHODS

Genes with functional roles in melanoma metastasis were discovered by analysis of next-generation sequencing data and case-control studies. We then used polymerase chain reaction to quantify gene expression in diagnostic biopsy tissue across a prospectively designed archival cohort of 754 consecutive thin- and intermediate-thickness primary cutaneous melanomas. Outcome of interest was SLN biopsy metastasis within 90 days of melanoma diagnosis. A penalized maximum likelihood estimation algorithm was used to train logistic regression models in a repeated cross-validation scheme to predict the presence of SLN metastasis from molecular, clinical, and histologic variables.

RESULTS

Expression of genes with roles in epithelial-to-mesenchymal transition (glia-derived nexin, growth differentiation factor 15, integrin-β3, interleukin 8, lysyl oxidase homolog 4, transforming growth factor-β receptor type 1, and tissue-type plasminogen activator) and melanosome function (melanoma antigen recognized by T cells 1) were associated with SLN metastasis. The predictive ability of a model that only considered clinicopathologic or gene expression variables was outperformed by a model that included molecular variables in combination with the clinicopathologic predictors Breslow thickness and patient age (area under the receiver operating characteristic curve, 0.82; 95% CI, 0.78 to 0.86; SLN biopsy reduction rate, 42%; negative predictive value, 96%).

CONCLUSION

A combined model that included clinicopathologic and gene expression variables improved the identification of patients with melanoma who may forgo the SLN biopsy procedure because of their low risk of nodal metastasis.
Considerations for Integration of Perioperative Electronic Health Records Across Institutions for Research and Quality Improvement: The Approach Taken by the Multicenter Perioperative Outcomes Group
Authors: Colquhoun Douglas A. , Shanks Amy M. , Kapeles Steven R. , Shah Nirav , Saager Leif , Vaughn Michelle T. , Buehler Kathryn , Burns Michael L. , Tremper Kevin K. , Freundlich Robert E. , Aziz Michael , Kheterpal Sachin , Mathis Michael R.
Published: April 2020

Use of the electronic health record (EHR) has become a routine part of perioperative care in the United States. Secondary use of EHR data includes research, quality, and educational initiatives. Fundamental to secondary use is a framework to ensure fidelity, transparency, and completeness of the source data. In developing this framework, competing priorities must be considered as to which data sources are used and how data are organized and incorporated into a useable format. In assembling perioperative data from diverse institutions across the United States and Europe, the Multicenter Perioperative Outcomes Group (MPOG) has developed methods to support such a framework. This special article outlines how MPOG has approached considerations of data structure, validation, and accessibility to support multicenter integration of perioperative EHRs. In this multicenter practice registry, MPOG has developed processes to extract data from the perioperative EHR; transform data into a standardized format; and validate, deidentify, and transfer data to a secure central Coordinating Center database. Participating institutions may obtain access to this central database, governed by quality and research committees, to inform clinical practice and contribute to the scientific and clinical communities. Through a rigorous and standardized approach to ensure data integrity, MPOG enables data to be usable for quality improvement and advancing scientific knowledge. As of March 2019, our collaboration of 46 hospitals has accrued 10.7 million anesthesia records with associated perioperative EHR data across heterogeneous vendors. Facilitated by MPOG, each site retains access to a local repository containing all site-specific perioperative data, distinct from source EHRs and readily available for local research, quality, and educational initiatives. Through committee approval processes, investigators at participating sites may additionally access multicenter data for similar initiatives. Emerging from this work are 4 considerations that our group has prioritized to improve data quality: (1) data should be available at the local level before Coordinating Center transfer; (2) data should be rigorously validated against standardized metrics before use; (3) data should be curated into computable phenotypes that are easily accessible; and (4) data should be collected for both research and quality improvement purposes because these complementary goals bolster the strength of each endeavor.
Early detection treatment response for head and neck carcinomas using intravoxel incoherent motion-magnetic resonance imaging: a meta-analysis
Authors: Song Qingxu , Li Fang , Chen Xin , Wang Jianbo , Liu Hong , Cheng Yufeng
Published: April 2020

Objectives:

To evaluate the diagnostic accuracy of intravoxel incoherent motion-MRI (IVIM-MRI) for predicting the treatment response in head and neck squamous cell carcinomas (HNSCC) patients.

Methods:

A comprehensive literature search was performed to identify original articles on diagnostic performance of IVIM in predicting treatment response in HNSCC patients receiving chemoradiotherapy. The IVIM parameters studied were diffusion coefficient (D), pseudodiffusion coefficient (D*), perfusion fraction (f), and apparent diffusion coefficient. Summary estimates of diagnostic accuracy were obtained by using a random-effects model. Of 65 studies screened, 8 studies with 347 patients were finally included.

Results:

The pooled sensitivities and specificities were 76% [95% confidence interval (CI) 69–82%] and 81% (95% CI 70–89%) for pre-treatment D, and 70% (95% CI 58–80%) and 82% (95% CI 66–92%) for △D, respectively. In addition, the sensitivities and specificities ranged from 41.7 to 94% and 67 to 100% for pre-treatment f, and from 55.7 to 76.5% and 72.2 to 93.3% for pre-treatment apparent diffusion coefficient, respectively.

Conclusions:

The diffusion-related coefficients pre-treatment D and △D demonstrated good accuracy in predicting early treatment response in HNSCC patients. However, because of the variability in reference test and other limitations of included literature, further investigation is needed before implementing any IVIM strategy into clinical practice.
Investigation of Success Factors of Projects for the Development and Market Launch of New Pharmacy Assortment Products
Authors: Efanov Danila
Published: April 2020

For any company, which is working with projects for the creation and launch of new pharmacy products on the market, it is extremely important to manage their projects effectively. This article is devoted to the study of the success factors of such projects. In the course of this study, numerous literature sources were analyzed concerning projects for the creation and introduction of new products to the market, on the basis of which a pool of factors was formed that are most relevant for the pharmacy range of products. Then a survey of respondents who were competent in this issue was conducted, based on the results of which, these factors were divided into three groups: key factors, secondary and insignificant. Based on the obtained classification, practical measures for using the analyzed factors in a real company were determined.
NHS sickness absence in England: hidden patterns
Authors: Jones Rodney P
Published: April 2020

Background/aims

Long-term trends in sickness absence have until now been assumed to be caused by economic cycles, age and gender changes in the workforce, and the success or failure of employers to reduce common causes of absence. This study aimed to identify unexplained patterns in sickness absence data.

Methods

A rolling 12-month average of sickness absence was used covering the 12 months ending March 2010 through to the 12 months ending October 2019. To determine the largest step increase in sickness absence, the average sickness absence rate was compared between successive 12-month periods.

Results

Time and space (spatiotemporal) patterns of up/down shifts are evident in the regional data across England. Over the 10-year period of the study, these patterns, rather than schemes to reduce sickness absence, appear to dominate the trend, which has shown no evidence of a change in the long-term average.

Conclusions

A rolling 12-month average, or more sophisticated methodologies, is required to detect and investigate less obvious spatiotemporal patterns in sickness absence data. Further research is required to investigate the causes of the up/down patterns observed in this data, which may be influencing sickness absences among NHS staff and wider health trends.
Patterns of sickness absence from a secondary hospital in Melbourne: a 10-year longitudinal study
Authors: Krejany Catherine , Gaedtke Lee , Kanjo Epi , Jiwa Moyez
Published: April 2020

Background/aims

There has been significant concern in recent years regarding increases in absenteeism in the healthcare sector, leading to lost productivity and projected workforce shortages. This study aimed to identify patterns of sickness absence over a 10-year period in a single-site secondary hospital in Melbourne, Australia.

Methods

Data regarding sickness absences were extracted from anonymised payroll records from 2007 to 2016. The patterns of sickness absence analysed included seasonality, amount of leave and category of leave. These were explored both for individuals and in the aggregate.

Results:

Compared to the Australian average of 9.7 days, this cohort of employees took less sick leave, averaging at 8.81 days each. As a group, a consistent proportion of staff took no sick leave, 1–3 days, 4–6 days, or 7–9 days each year in the 10-year timespan. Only a small proportion took more than 9 days of sickness leave per year.

Conclusions

The pattern of leave-taking was consistent for the group as a whole, however, individual leave patterns vary.
Handling concerns raised about doctors: time for local changes
Authors: Rowland Andrew Graeme , Mohan Keerthi
Published: April 2020

NHS organisations must be assured that appropriate protections and support are in place for their employees, especially when incidents occur or concerns arise. These assurances are an essential part of fostering a just and inclusive culture under an overarching banner of compassionate leadership, while also ensuring that any concerns are properly investigated. In mid-2019, the General Medical Council published their Hamilton review into Gross Negligence Manslaughter. As a result, NHS Improvement wrote to NHS trusts about managing local investigation processes for disciplinary investigations of all types. Employers and educators of healthcare professionals have a responsibility to consider how they will put these recommendations and requirements into practice, yet there is currently no clear implementation guidance. The authors make implementation recommendations that should be considered by NHS organisations and Health Education England as part of their compassionate leadership and just culture processes.
Newly qualified health visitor: COVID-19 – a public health crisis
Authors: Boddy Bethany
Published: April 2020

Bethany Boddy explores the fast-changing public health emergency of COVID-19 and the health visitor response
Taking action to secure a healthy future for all
Authors: Ranmal Rita , Elwell-Sutton Tim
Published: April 2020

In this article, Rita Ranmal and Tim Elwell-Sutton look at recent trends in population health, the conditions needed for healthy lives and some effective actions that can be taken to secure the public's health in the long term
238. Aprender y enseñar con la escala del mapa para el profesorado de la “generación Z”: la competencia digital docente
Authors: Gómez-Trigueros Isabel María , Binimelis Jaume
Published: April 2020

El Espacio Europeo de Educación Superior (EEES) advierte de la necesidad de formar en competencia digital docente (CDD) al futuro profesorado, para la educación de una ciudadanía responsable y capaz del siglo XXI. El propósito de este estudio es analizar la percepción de las CDD del alumnado de Grado de Primaria a través de la TIG Google EarthTM para desarrollar el concepto de escala gráfica y numérica. Se ha utilizado una metodología mixta, activa y participativa partiendo de contenidos teóricos geográficos (conceptuales) que se han analizado y explicado en el aula relacionándolos con contenidos prácticos (procedimentales). El trabajo desarrollado por la muestra participante fue grupal y cooperativo (398 estudiantes). Los resultados arrojan una percepción positiva del alumnado sobre su propia CDD que contrasta con un deficiente uso manipulativo y didáctico de las tecnologías. A partir de tales resultados se corrobora la necesidad de aplicar una mejora en la formación tecnológica manipulativa y didáctica del profesorado en formación.
Disturbed partial discharge detection system based on an improved Φ-OTDR assisted by a wFBG array
Authors: Zhu Peng , Wen Hongqiao , Che Qian , Li Xinyu
Published: April 2020

Partial discharge (PD) detection is an effective method for evaluating the insulation status of power cables. In this paper, a disturbed acoustic sensing (DAS) system based on phase-sensitive optical time-domain reflectometry (

Φ

-OTDR) for online PD detecting is proposed and demonstrated. To detect the ultra-small fiber strain induced by PD, a weak fiber Bragg grating (wFBG) array is introduced into the sensing fiber to increase signal-to-noise ratio (SNR) of the system. Besides, the sensing fiber is packaged with aluminum tape to enhance the sensitivity. Consistent PD signals in a 10 kV cross linked polyethylene (XLPE) power cable with artificial defects have been observed, and characteristics of the signals are analyzed.
DMD-based three-dimensional chromatic confocal microscopy
Authors: Li Shaobai , Liang Rongguang
Published: April 2020

In this paper, a digital mirror device (DMD)-based chromatic confocal microscopy is proposed and demonstrated for three-dimensional (3D) surface profiling without any mechanical scanning. In this method, the DMD works as the multipoint source and multi-pinhole at the same time to achieve the lateral scanning. Moreover, axial scanning is realized through the chromatic aberration of the confocal optics. Since the micromirror array of the DMD is not perpendicular to the confocal imaging axis, a corresponding calibration is needed to eliminate the tilt effects and perform accurate 3D imaging. The measurement range with the current optical system is 45 µm over 505–650 nm working spectrum and can be increased by using a custom objective with large chromatic aberration. The system performance has been demonstrated with a multistep sample.
Polarized lidar and ocean particles: insights from a mesoscale coccolithophore bloom
Authors: Collister Brian L. , Zimmerman Richard C. , Hill Victoria J. , Sukenik Charles I. , Balch William M.
Published: April 2020

Oceanographic lidar can provide remote estimates of the vertical
distribution of suspended particles in natural waters, potentially
revolutionizing our ability to characterize marine ecosystems and
properly represent them in models of upper ocean biogeochemistry.
However, lidar signals exhibit complex dependencies on water column
inherent optical properties (IOPs) and instrument characteristics,
which complicate efforts to derive meaningful biogeochemical
properties from lidar return signals. In this study, we used a
ship-based system to measure the lidar attenuation coefficient (

α

) and linear depolarization ratio (

δ

) across a variety of optically and
biogeochemically distinct water masses, including turbid coastal
waters, clear oligotrophic waters, and calcite rich waters associated
with a mesoscale coccolithophore bloom. Sea surface IOPs were measured
continuously while underway to characterize the response of

α

and

δ

to changes in particle abundance and
composition. The magnitude of

α

was consistent with the diffuse
attenuation coefficient (

K

d

), though the

α

versus

K

d

relationship was nonlinear.

δ

was positively related to the
scattering optical depth and the calcite fraction of backscattering. A
statistical fit to these data suggests that the polarized scattering
properties of calcified particles are distinct and contribute to
measurable differences in the lidar depolarization ratio. A better
understanding of the polarized scattering properties of
coccolithophores and other marine particles will further our ability
to interpret polarized oceanographic lidar measurements and may lead
to new techniques for measuring the material properties of marine
particles remotely.
Compact off-axis holographic slide microscope: design guidelines
Authors: Cacace Teresa , Bianco Vittorio , Mandracchia Biagio , Pagliarulo Vito , Oleandro Emilia , Paturzo Melania , Ferraro Pietro
Published: April 2020

Holographic microscopes are emerging as suitable tools for in situ diagnostics and environmental monitoring, providing high-throughput, label-free, quantitative imaging capabilities through small and compact devices. In-line holographic microscopes can be realized at contained costs, trading off complexity in the phase retrieval process and being limited to sparse samples. Here we present a 3D printed, cost effective and field portable off-axis holographic microscope based on the concept of holographic microfluidic slide. Our scheme removes complexity from the reconstruction process, as phase retrieval is non iterative and obtainable by hologram demodulation. The configuration we introduce ensures flexibility in the definition of the optical scheme, exploitable to realize modular devices with different features. We discuss trade-offs and design rules of thumb to follow for developing DH microscopes based on the proposed solution. Using our prototype, we image flowing marine microalgae, polystyrene beads, E.coli bacteria and microplastics. We detail the effect on the performance and costs of each parameter, design, and hardware choice, guiding readers toward the realization of optimized devices that can be employed out of the lab by non-expert users for point of care testing.
Reporting with emotion: A comparison of journalists' engagement in emotional labour across media types
Authors: Huxford John E. , Hopper K. Megan
Published: April 2020

This study explores the process of emotional labour in journalism. In a series of one-on-one interviews, journalists reflected upon their experiences while gathering the news and agreed they do indeed engage in emotional labour, suppressing or manipulating their own emotions as part of the job at hand. However, while journalists across media share much in common in this process, this study identifies important subsets within the profession. Across the divide of print and television, journalists draw on quite different types of working practice in their pursuit of news and have markedly different mindsets and attitudes towards emotional labour, as well as relying on different mechanisms for coping with the difficulties that arise from emotional control. Our findings show that with little or no training in this practice, and with the majority of journalists achieving merely a deferment of upsetting emotions, emotional labour can have serious implications for those reporters who engage in it.
O depósito metálico de Agro Velho-Montalegre e a sua relação com o Sudoeste Peninsular (?)
Authors: Soares Joaquina , Valério Pedro , Soares António Monge , Araújo Maria De Fátima
Published: April 2020

Identificação e caracterização arqueometalúrgica de um machado plano em bronze binário, de tipo Bujões-Barcelos, que integrou o depósito de Agro Velho, em Montalegre, importante região mineira rica em estanho, onde se tem encontrado uma das evidências mais antigas das produções bronzíferas do país, atribuídas ao Bronze médio, 2º quartel do II milénio a.C. Pelas vicissitudes do trabalho arqueológico, a biografia do nosso machado viria a cruzar-se com a história do quiçá mais importante complexo científico-museológico português, enraizado na segunda metade do século XVIII. Localizado nas primitivas instalações da Faculdade de Ciências da Universidade de Lisboa, foi quase totalmente destruído por vasto incêndio em 1978. Miraculosamente salvo do incêndio, o machado do depósito de Agro Velho aqui estudado encontra-se actualmente depositado no Museu de Arqueologia e Etnografia do Distrito de Setúbal (MAEDS).
Gruta da Igrejinha dos Soídos (Alte, Loulé): contribuição para o estudo do final da pré-história no Algarve
Authors: Carvalho António Faustino , Veríssimo Humberto
Published: April 2020

Trabalhos realizados em 1988 na gruta da Igrejinha dos Soidos sob a direção de L.G. Straus permitiram identificar uma ocupação que se pode hoje atribuir ao final da Idade do Bronze (c. 1400 a.C.?), colocando assim este sítio entre os poucos contextos não funerários desta época conhecidos no Algarve. Para além de cerâmica característica deste período (bases planas, paredes brunidas), incluindo cinchos, regista-se ainda um conjunto faunístico diversificado que atesta uma economia pastoril (ovelha / cabra e boi).
Importaciones Mediterráneas en el cerro del Castillo de Medellín (Badajoz): cerámicas griegas y escarabeo de las campañas 2014 y 2015
Authors: Ávila Javier Jiménez , López Ángel Carbajo , González Montaña Luengo
Published: April 2020

Durante las campañas de excavaciones realizadas en 2014 y 2015 en el Cerro del Castillo de Medellín (Badajoz) apareció un buen número de cerámicas griegas de los siglos V y IV a. C. que vienen a sumarse a lo que ya se conocía sobre ese tipo de importaciones en este yacimiento. A pesar de que prácticamente todos son hallazgos descontextualizados, procedentes de UEs romanas y posteriores, tanto por su cantidad como por la calidad de algunos ítems, sirven para subrayar la importancia de Medellín durante toda la Edad del Hierro. Como complemento, se presenta también un escarabeo egipcio hallado en similares condiciones.
Quinta da Praia (Samouco, Alcochete): testemunhos do neolítico antigo na margem esquerda do estuário do Tejo
Authors: Carvalho António Faustino , Correia Miguel , Moisés Marisa
Published: April 2020

Descoberto em 2003, o sítio arqueológico da Quinta da Praia pode ser atribuído ao Neolítico antigo com base na sua cultura material (cerâmica impressa e incisa, talhe do sílex para a produção de uma indústria de base lamelar, etc.). Sondagens e prospeções subsequentes, incluindo a recolha sistemática de artefactos de superfície, permitiram o reconhecimento de três concentrações principais de líticos e fragmentos cerâmicos. O estatuto das mesmas (se contemporâneas ou sucessivas no tempo) é ainda uma questão em aberto. A localização do sítio sobre a margem sul do Estuário do Tejo sugere a exploração dos seus recursos enquanto o sistema de povoamento coevo, por seu lado, indica a presença de uma economia agro-pastoril plena formada.
La Cueva del Cañaveralejo (Adamuz, Córdoba, España) en la prehistoria reciente de Sierra Morena: nuevas aportaciones.
Authors: Expósito Isabel María Jabalquinto , De la Cruz José Clemente Martín
Published: April 2020

Se presentan los resultados obtenidos en la excavación de los cortes B, C y A de la Cueva del Cañaveralejo. Aunque gran parte de los sedimentos han sido alterados por la acción humana y de los animales por medio de excavación de madrigueras, el estudio de los materiales, combinando la secuencia estratigráfica con la morfología, permiten plantear una ocupación inicial que se remonta al neolítico antiguo, al menos en el tránsito del VI a V milenio a.C., que se continúa con algún hiatus durante el IV y el III milenio a.C. La cueva continuó siendo frecuentada durante el III y II milenio a.C. de forma temporal y relacionada con la ocupación del territorio exterior a la cavidad.
Castelo Velho de Freixo de Numão, um sítio, uma paisagem
Authors: Cardoso João Muralha
Published: April 2020

Neste texto pretende-se inserir Castelo Velho de Freixo de Numão numa rede de sítios genericamente contemporâneos. Parte-se de um intenso trabalho de prospecção efectuado nos últimos anos e reflecte-se sobre a paisagem arqueológica e a categorização dos sítios encontrados.
Castelo Velho: um projeto comum de arquitectura e paisagem?
Authors: Figueiral Isabel
Published: April 2020

Os restos vegetais carbonizados (carvões e sementes) recuperados durante as campanhas de escavação realisadas em Castelo Velho foram analisados com o objetivo d’obter informações sobre o contexto ambiental e económico no seio do qual o projeto arquitectónico tomou forma. Os resultados obtidos parecem sugerir uma possivel gestão voluntária da paisagem vegetal de forma a assegurar a visibilidade do recinto murado. A descoberta de uma estrutura repleta de sementes (cevada de grão vestido, trigo de grão nu e papoila d’ópio), associadas a cêramica, é particularmente marcante num sitio onde os restos de sementes/frutos são muito raros. Trata-se possivelmente de um depósito simbólico.
Revisitar o estudo dos pesos de tear de Castelo Velho de Freixo Numão. As deposições como uma antologia de existências
Authors: Gomes Sérgio
Published: April 2020

Neste texto é reavaliado um trabalho anteriormente apresentado acerca dos pesos de tear do recinto de Castelo Velho de Freixo de Numão (Gomes 2013). É discutido o modo como tal trabalho desenvolve a análise dos contextos onde aparecem este tipo de artefactos e as conclusões a que se chegou em tal análise. A partir da ênfase que foi dada à prática de deposição na interpretação dos contextos, salienta-se que não foram exploradas as possibilidades interpretativas que as deposições comportavam enquanto uma unidade do registo arqueológico. Com efeito, a argumentação suspende a interpretação das deposições a uma escala contextual, subindo à escala do recinto para posicionar as práticas de deposição no quadro de relações intra e inter-comunitárias que estariam associadas à sua construção. Neste movimento, é reproduzido um esquema narrativo que tem privilegiado a ação de outras entidades (a arquitetura e a cerâmica, por exemplo) como estratégia de organizar a narrativa. Para além disto, este movimento também parece ignorar que as práticas de deposição – enquanto práticas de consignação de diferentes elementos – fazem emergir novas entidades, que teriam participado na cena social das comunidades pré-históricas. Face a isto, defende-se que é necessário reorientar a análise e os esquemas narrativos para recriar o lugar destas existências nas narrativas que produzimos sobre a pré-história.
A DECORAÇÃO “AO ROMANO” E A PRESENÇA DE JOÃO DE RUÃO NA TUMULÁRIA DE GÓIS E TROFA DO VOUGA.
Authors: Vaz Ana Margarida , Pereira Gabriel
Published: April 2020

Os monumentos fúnebres de D. Luís da Silveira e de D. Duarte de Lemos, respetivamente em Góis e na Trofa do Vouga, revelam-se obras indissociáveis devido à forma como os encomendantes surgem representados. A generalidade dos autores reconheceu as proximidades entre as duas obras, porém tenderam a ignorar a componente decorativa e é esta, na ausência de nova documentação, que constitui o principal meio de identificação e descodificação de autorias.

Aqui, pretendem-se trazer à luz a natureza do ornamento e a decoração presente na tumulária e mostrar como ela obedece à mesma cultura plástica irradiada pelo Renascimento coimbrão, ainda que com trabalho de qualidade díspar – fruto da forma distinta como João de Ruão se envolveu nos dois projetos.
A GENEALOGIA EUCLIDIANA DAS COMPOSIÇÕES ESCULTÓRICAS DE JOÃO DE RUÃO.
Authors: Vaz Ana Margarida , Henriques Francisco
Published: April 2020

Ativo participante do seu zeitgeist, erudito, culto e esclarecido, dotado de singular sensibilidade artística e mestria escultórica, João de Ruão evidencia na sua obra conhecimentos notáveis na aplicação da ciência geométrica euclidiana.O presente texto analisa e clarifica os fundamentos geométricos apriorísticos da génese compositiva da obra de João de Ruão, e a sagaz articulação destes mecanismos de significação – por adequação dos diferentes elementos estruturais e figurativos das suas organizações compositivas – para composição de notáveis discursos imbuídos de vívida significação espiritual.
MIGUEL PERRIN Y LA INFLUENCIA DEL MODELO ESCULTÓRICO FRANCÉS EN LA ESCULTURA EN BARRO COCIDO EN ANDALUCÍA
Authors: Vaz Ana Margarida , Paíl Teresa Laguna
Published: April 2020

Miguel Perrin, imaginero francés especializado en la escultura monumental en barro cocido, desarrolló la mayor parte de su actividad profesional en Sevilla entre 1517 y 1552. La investigación actualiza la historiografía de este escultor, su aportación en la normalización de los modelos del primer Renacimiento en esta ciudad cosmopolita, abierta al comercio y a las vanguardias intelectuales. Establece análisis de su cultura visual, condicionantes técnicos y modelos de sus obras contextualizándolas con los trabajos de otros escultores de formación e idéntica procedencia, que tuvieron un protagonismo destacado en la normalización de los tipos humanistas italianos.
DE LA SCULPTURE RELIGIEUSE EN NORMANDIE ORIENTALE (1480-1530). ÉVOCATION DU CONTEXTE SCULPTURAL CONTEMPORAIN DE LA FORMATION DE JEHAN DE ROUEN.
Authors: Vaz Ana Margarida , Trotin Nicolas
Published: April 2020

A decifração do sentido da escultura normanda entre 1480 e 1530, exatamente o tempo precedente à estadia de João de Ruão em Coimbra, é o objetivo maior desta análise. Encontrar os elos de ligação entre a plasticidade escultórica num território onde se infiltra a presença de modelos e artistas italianos e a produção de João de Ruão em Portugal constitui um desafio para o qual é necessário avançar com soluções e novas perspetivas de interpretação. As origens do escultor francês, as suas referências e a sua formação inicial são aqui equacionadas de modo a poder estabelecer uma rede mais clara do trabalho artístico e a sua capacidade para ultrapassar as fronteiras políticas no século XVI.
LOPEZ FEREZ, Juan Antonio (eds.), Galeno. Lengua, composicion literaria, lexico, estilo, 444 pp., Madrid, Ediciones Clásicas, 2015, ISBN: 84-7882-743-9
Authors: Ferreira Nelson Henrique
Published: April 2020

Galeno. Lengua, composicion literaria, lexico, estilo
British Council Research Link Cambridge-Brasilia. Plato’s Communities: Citizenship and Diversity
Authors: Rodrigues Ália
Published: April 2020

Notícia
Clinical Characteristics of COVID-19 Patients With Digestive Symptoms in Hubei, China: A Descriptive, Cross-Sectional, Multicenter Study
Authors: Pan Lei , Mu Mi , Yang Pengcheng , Sun Yu , Wang Runsheng , Yan Junhong , Li Pibao , Hu Baoguang , Wang Jing , Hu Chao , Jin Yuan , Niu Xun , Ping Rongyu , Du Yingzhen , Li Tianzhi , Xu Guogang , Hu Qinyong , Tu Lei
Published: April 2020

OBJECTIVE:

Since the outbreak of Coronavirus Disease 2019 (COVID-19) in December 2019, various digestive symptoms have been frequently reported in patients infected with the virus. In this study, we aimed to further investigate the prevalence and outcomes of COVID-19 patients with digestive symptoms.

METHODS:

In this descriptive, cross-sectional, multicenter study, we enrolled confirmed patients with COVID-19 who presented to 3 hospitals from January 18, 2020, to February 28, 2020. All patients were confirmed by real-time polymerase chain reaction and were analyzed for clinical characteristics, laboratory data, and treatment. Data were followed up until March 18, 2020.

RESULTS:

In the present study, 204 patients with COVID-19 and full laboratory, imaging, and historical data were analyzed. The average age was 52.9 years (SD ± 16), including 107 men and 97 women. Although most patients presented to the hospital with fever or respiratory symptoms, we found that 103 patients (50.5%) reported a digestive symptom, including lack of appetite (81 [78.6%] cases), diarrhea (35 [34%] cases), vomiting (4 [3.9%] cases), and abdominal pain (2 [1.9%] cases). If lack of appetite is excluded from the analysis (because it is less specific for the gastrointestinal tract), there were 38 total cases (18.6%) where patients presented with a gastrointestinal-specific symptom, including diarrhea, vomiting, or abdominal pain. Patients with digestive symptoms had a significantly longer time from onset to admission than patients without digestive symptoms (9.0 days vs 7.3 days). In 6 cases, there were digestive symptoms, but no respiratory symptoms. As the severity of the disease increased, digestive symptoms became more pronounced. Patients with digestive symptoms had higher mean liver enzyme levels, lower monocyte count, longer prothrombin time, and received more antimicrobial treatment than those without digestive symptoms.

DISCUSSION:

We found that digestive symptoms are common in patients with COVID-19. Moreover, these patients have a longer time from onset to admission, evidence of longer coagulation, and higher liver enzyme levels. Clinicians should recognize that digestive symptoms, such as diarrhea, are commonly among the presenting features of COVID-19 and that the index of suspicion may need to be raised earlier in at-risk patients presenting with digestive symptoms. However, further large sample studies are needed to confirm these findings.
Meillassoux y Deleuze en torno a la inmanencia
Authors: Antonelli Marcelo
Published: April 2020

Quentin Meillassoux (1967) es un filósofo francés que ha cobrado notoriedad a partir de la publicación de Après la finitude. Essai sur la nécessité de la contingence en 2006. Su obra se inscribe en el Realismo Especulativo, movimiento de reciente expansión en el campo filosófico contemporáneo que promueve una ontología realista. Además de reivindicar una filosofía materialista, Meillassoux defiende la inmanencia ya en su tesis doctoral L’inexistence divine y, especialmente, en el artículo “L’immanence: d’outre-monde” (2009), donde afirma que una verdadera filosofía de la inmanencia no puede fundamentarse en un pensamiento de la finitud sino en una ética de la inmortalidad. Meillassoux opone su perspectiva, aparentemente paradójica, de una inmanencia “de otro mundo” a los pensamientos contemporáneos de la inmanencia, esencialmente al de Deleuze, quien hizo de dicho concepto un blasón de su proyecto filosófico. En este artículo queremos ensayar una confrontación entre la idea de Meillassoux de una creencia en el Mundo de la Justicia y la propuesta deleuziana de una creencia en este mundo con vistas a elucidar convergencias y divergencias relevantes en sus abordajes de la inmanencia y sus concepciones del vínculo entre la filosofía y el ateísmo.
Espacio e inteligencia en Arturo Ardao: su contribución a una filosofía de la cultura americana
Authors: Martin De Blassi Fernando
Published: April 2020

Este trabajo aborda la comprensión que A. Ardao desarrolla sobre el espacio y su primacía con respecto al tiempo. En otros términos, el tiempo como subsidiario del espacio, así como la razón en cuanto subsidiaria de la inteligencia. Esta misma inversión categorial fundamenta la ocupación que nuestro autor asigna al ejercicio del filosofar latinoamericano como una tarea afincada en una geografía concreta, delimitada por parámetros culturales y protagonizada por un sujeto que no es una sustancia racional, sino un ente biofísico en quien se clausura la historia como geo-historia y se da paso al desarrollo de una astro-historia a partir de la conquista del espacio exterior.
Los discursos de lo público y su alcance político
Authors: Paolicchi Leandro
Published: April 2020

El trabajo se extiende en un breve examen del lugar asignado por algunos autores como Jürgen Habermas, Karl-Otto Apel o Julio De Zan al discurso como instancia de legitimidad y crítica meta institucional de la sociedad. Haciendo un repaso de posiciones contrarias como las de Arnold Gehlen o Niklas Luhmann se procura establecer los alcances y los límites del espacio público –topos natural del discurso– como lugar paradigmático para interrelaciones sociales de fuerte contenido normativo orientadas hacia la validez de las instituciones. Por último, se realizan una serie de precisiones que son necesarias para esa reivindicación del espacio público político.
La relación entre ética y política en la democracia deliberativa. Un análisis crítico de la “Significación moral de la democracia”, de Julio De Zan
Authors: Prono Santiago
Published: April 2020

El artículo analiza el problema de la relación entre ética y política teniendo en cuenta para ello el trabajo de J. De Zan sobre la “Significación moral de la democracia” (1991). La idea es complementar, no sin señalamientos críticos, dicho trabajo identificando, en primer lugar, el sentido reconstructivo del planteamiento teórico de la democracia deliberativa de J. Habermas. Para este propósito, se explicita también una parte de sus fundamentos filosóficos, como es la pragmática universal del lenguaje, cuya tematización de las pretensiones universales de validez del discurso argumentativo permite identificar el carácter moralmente constitutivo de la racionalidad argumentativa, y por lo tanto de la democracia deliberativa. Aunque de un modo indirecto, este trabajo se propone discutir críticamente también con el actual posicionamiento habermasiano sobre el tema.
Development of an algorithm for the identification of leukemic hematolymphoid neoplasms in Primary Care patients
Authors: Quirós Covadonga , Fonseca Ariana , Alonso-Álvarez Sara , Moro-García Marco Antonio , Alonso-Arias Rebeca , Morais Lucía-Rita , Álvarez-Menendez Francisco V. , Colado Enrique
Published: April 2020

Background

Diagnosis of hematolymphoid neoplasm (HLN) requires different technologies which are performed on a patient basis instead of per protocol. We hypothesize that integration of hematimetric and cytological analysis along with multiparametric flow cytometry (MFC) provides a framework to evaluate peripheral blood (PB) samples from Primary Care.

Methods

Samples from patients with persistent (>3 months) lymphocytosis (>5 × 109/L) and/or monocytosis (>109/L) or the presence of atypical and/or blast cells upon the smear review were analyzed by MFC concurrent to cytological analysis. MFC studies were carried out following standardized procedures.

Results

In a 3-year period, smear review and MFC were performed simultaneously in 350 samples, demonstrating HLN in 194 cases (55.4%). In 156 cases, reactive cell populations were found. The combination of age, absolute lymphocyte count (ALC), hemoglobin and platelets provided the best correlation with MFC for the presence of a chronic lymphoproliferative disorder (CLPD) in lymphocytosis [area under the curve (AUC) 0.891, p < 0.05]. A model evaluating the probability of CLPD has been proposed and validated in an independent cohort.

Conclusions

A strategy to perform MFC studies following standardized procedures has proven to be useful to evaluate samples from patients in Primary Care centers for HLN diagnosis or reactive conditions, providing a sensitive and rapid clinical orientation and avoiding unnecessary consultations in routine clinical practice. The probability for the presence of CLPD in PB can be calculated and help guide decision-making regarding further testing.
Comparison Between Linear and Nonlinear Governor Power Flow Formulations
Authors: Passos Filho João Alberto , Ferreira Avila Othon , Oliveira La Gatta Paula
Published: April 2020

The main objective of this paper is to review and compare two methodologies to solve the power flow problem considering active power generation droop control. The first methodology is based on a DC power flow model, and the second one is based on a conventional full Newton power flow formulation. The study of two test systems is used to validate the proposed analysis; the first one is the 11-bus system with two distinct areas, and the second one is the 39-bus New England power system. The results presented validate and indicate the effectiveness of the DC power flow approach in order to estimate the steady-state system frequency deviations.
Ethnobotanical survey of three members of family Lamiaceae among the inhabitants of Bejaia, Northern Algeria
Authors: Khaled-Khodja Nabyla , Brahmi Fatiha , Madani Khodir , Boulekbache-Makhlouf Lila
Published: April 2020

Background

This paper presents the uses of Calamintha nepeta, Teucrium flavum and Thymus numidicus in food and in traditional herbal medicines in six districts from Bejaia state, Northern Algeria.

Materials

A semi-structured interview was conducted to 52 informants, including questions on the demographic data of the informants and uses of the three medicinal plants to determine the alimentary and the medicinal uses of these plants in Bejaia state.

Results

The demographic data of the informants indicate that rural participants are the principal consumers of medicinal plants. Data regarding experience of medicinal plants preparation show that 36.5% was confined to the experienced informants, while 63.5% of the informants were inexperienced. Women used medicinal plants more frequently than men; it is recorded that there were 42.3% male informants and 57.7% female informants. Studied plants were used for curing a total of 10 diseases. Also, C. nepeta and T. numidicus were applied as condiment in food, but T. flavum was found to have no food uses in all districts.

Conclusion

Bejaia district is rich in biodiversity of food and medicinal plants and there is need for further studies to validate their use as potential drugs.
Effect of pre-cesarean foot reflexology massage on anxiety of primiparous women
Authors: Navaee Maryam , Khayat Samira , Abed Zahra Ghadiri
Published: April 2020

Introduction

Anxiety is a common feeling in cesarean section and lack of attention to it is associated with negative consequences for health of mother and child. Reflexology is a way to reduce anxiety. So far, the effect of reflexology on pre-cesarean anxiety has not been evaluated. Therefore, we aimed to evaluate the effect of pre-cesarean foot reflexology massage on the anxiety of women during their first pregnancy.

Materials and Methods

This study is a three-group clinical trial that was conducted in 2019. The study sample consisted of 90 pregnant women hospitalized for cesarean section in Zahedan who were randomly divided into three groups of 30 women. The subjects completed the state section of Spielberger anxiety questionnaire. The control group did not receive any intervention. For two groups, 1 h before surgery, a group received reflexive massage, and the another group simple massage. Duration of massage for each group was 30 min. After 30 min, the subjects completed the state section of Spielberger questionnaire again. Statistical analysis was performed by SPSS software program, version 21.0. ANOVA and ANCOVA tests were used to compare between groups and paired t-test was used for intra-group comparisons.

Results

The results showed that the level of anxiety was significantly reduced in the reflexology massage group (from 55 ± 8 to 40 ± 7) as well as simple massage group (from 51 ± 10 to 47 ± 7) (p<0.001). In the control group, anxiety was increased (from 49 ± 9 to 56 ± 9) (p<0.001). Comparison between the three groups by ANCOVA indicated that reflexology massage and simple massage significantly decreased anxiety scores (p>0.001 and p>0.001,respectively). Reflexive massage significantly reduced anxiety scores (p>0.001) as compared to simple massage.

Conclusion

The results of this study revealed the positive effect of reflexology massage on pre-cesarean anxiety. Because reflexology massage is an inexpensive, simple, and easy approach, the use of this non-pharmaceutical method is recommended to reduce pre-cesarean anxiety.
Evaluation of subacute toxicity and herb–drug interaction potential of an herbal Arishta formulation
Authors: Dey Amitabha , Kanjilal Satyajyoti , Bhatt Bibhuti N , Mohapatra Satyabrata , Chakraborty Tulika , Bhide Ranjit , Narwaria Avinash , Katiyar Chandra K
Published: April 2020

Background

Arishta technology is an age-old heritage and uses herbal decoctions to prepare self-generated alcoholic medicines. In Ayurveda, Arishta preparations are widely used as a remedy for metabolic disorders. However, their safety and influence on herb metabolism pathways were not yet explored. Aim: To study the subacute toxicity of a polyherbal Arishta formulation (coded as DB-07) in rats and to evaluate its potential for inhibition of the drug-metabolizing enzyme (Cytochrome P450 3A4).

Methodology

Experimentally naive rats were treated with graded oral doses of DB-07 (10 and 20 mL/kg/day) for 28 days. During the course of the experiment, all the animals were closely observed for apparent behavioural abnormalities and mortalities. Tissue histology was performed to assess any sign of toxicity. In addition, in vitro CYP3A4 inhibition assay was performed to study the effect on drug metabolism pathways.

Results

Animals did not show any change in body weight, organ toxicity and food consumption throughout the dosing period of 28 days. Pathophysiological, behavioural status and locomotor activity were not altered. DB-07 did not inhibit CYP3A4 enzyme and drug metabolism pathway in-vitro. Gallic acid and quercetin were identified as phytomarker from the formulation that may be responsible for its activity related safety issue.

Conclusion

These results indicate that use of DB-07 may be safe with no sign of toxicity for up to 28 days in rats. Further, CYP3A4 inhibition assay indicated that DB-07 is less likely to have herb–drug interactions when concomitantly administered with CYP3A4 inhibitors or inducer.