bluuebunny/crossref_metadata_2025 huggingface dataset:
SGIV Induced and Exploited Cellular De Novo Fatty Acid Synthesis for Virus Entry and Replication
Authors: Zheng Qi , Huang Youhua , Wang Liqun , Zhang Ya , Guo Xixi , Huang Xiaohong , Qin Qiwei
Published: January 2022

Considerable attention has been paid to the roles of lipid metabolism in virus infection due to its regulatory effects on virus replication and host antiviral immune response. However, few literature has focused on whether lipid metabolism is involved in the life cycle of lower vertebrate viruses. Singapore grouper iridovirus (SGIV) is the causative aquatic virus that extensively causes fry and adult groupers death. Here, the potential roles of cellular de novo fatty acid synthesis in SGIV infection was investigated. SGIV infection not only increased the expression levels of key enzymes in fatty acid synthesis in vivo/vitro, including acetyl-Coenzyme A carboxylase alpha (ACC1), fatty acid synthase (FASN), medium-chain acyl-CoA dehydrogenase (MCAD), adipose triglyceride lipase (ATGL), lipoprotein lipase (LPL) and sterol regulatory element-binding protein-1 (SREBP1), but it also induced the formation of lipid droplets (LDs), suggesting that SGIV altered de novo fatty acid synthesis in host cells. Using the inhibitor and specific siRNA of ACC1 and FASN, we found that fatty acid synthesis was essential for SGIV replication, evidenced by their inhibitory effects on CPE progression, viral gene transcription, protein expression and virus production. Moreover, the inhibitor of fatty acid β-oxidation could also reduce SGIV replication. Inhibition of fatty acid synthesis but not β-oxidation markedly blocked virus entry during the life cycle of SGIV infection. In addition, we also found that inhibition of ACC1 and FASN increased the IFN immune and inflammatory response during SGIV infection. Together, our data demonstrated that SGIV infection in vitro regulated host lipid metabolism and, in that process, cellular fatty acid synthesis might exert crucial roles during SGIV infection via regulating virus entry and host immune response.
The Course of Anti-HBc Antibodies over Time in Immunocompromised Hosts
Authors: Holtkamp Caroline , Fiedler Melanie , Dittmer Ulf , Anastasiou Olympia E.
Published: January 2022

Hepatitis B virus infection results in the appearance of anti-HBc antibodies that normally persist lifelong. We analyzed the course of anti-HBc antibodies overtime, focusing on patients with a permanent loss or fluctuating anti-HBc antibodies. From 120,531 patients tested for anti-HBc antibodies (Architect, Abbott) from January 2006 to December 2020, ≥4 serial values were available in 8098 and permanent or intermittent anti-HBc loss was observed in 139 patients. It was relatively frequent in baseline anti-HBc positive, immunocompromised patients with available serial measurements of anti-HBc overtime (13% of hematologic/oncologic patients, 10% of solid organ transplant recipients, and 6% of HIV patients compared to 3% in patients with other diseases). In the same period, 12,607 samples were tested for HBsAg, anti-HBc antibodies, and HBV DNA—in nine cases we detected HBV DNA with undetectable anti-HBc and HBsAg. In four out of nine cases contamination of the PCR during processing was the likeliest cause, in another four, no further data were available, while in one the HBV DNA was later followed by a temporary anti-HBc seroconversion. In conclusion, permanent or intermittent anti-HBc loss is more common in immunocompromised hosts than in patients with other underlying diseases. Furthermore, anti-HBc and HBsAg assays can be safely used to exclude an active HBV infection, even in immunocompromised hosts.
Establishment of an Artificial Neural Network Model Using Immune-Infiltration Related Factors for Endometrial Receptivity Assessment
Authors: Li Bohan , Duan Hua , Wang Sha , Wu Jiajing , Li Yazhu
Published: January 2022

Background: A comprehensive clinical strategy for infertility involves treatment and, more importantly, post-treatment evaluation. As a component of assessment, endometrial receptivity does not have a validated tool. This study was anchored on immune factors, which are critical factors affecting embryonic implantation. We aimed at establishing novel approaches for assessing endometrial receptivity to guide clinical practice. Methods: Immune-infiltration levels in the GSE58144 dataset (n = 115) from GEO were analysed by digital deconvolution and validated by immunofluorescence (n = 23). Then, modules that were most associated with M1/M2 macrophages and their hub genes were selected by weighted gene co-expression network as well as univariate analyses and validated using the GSE5099 macrophage dataset and qPCR analysis (n = 19). Finally, the artificial neural network model was established from hub genes and its predictive efficacy validated using the GSE165004 dataset (n = 72). Results: Dysregulation of M1 to M2 macrophage ratio is an important factor contributing to defective endometrial receptivity. M1/M2 related gene modules were enriched in three biological processes in macrophages: antigen presentation, interleukin-1-mediated signalling pathway, and phagosome acidification. Their hub genes were significantly altered in patients and associated with ribosomal, lysosomal, and proteasomal pathways. The established model exhibited an excellent predictive value in both datasets, with an accuracy of 98.3% and an AUC of 0.975 (95% CI 0.945–1). Conclusions: M1/M2 polarization influences endometrial receptivity by regulating three gene modules, while the established ANN model can be used to effectively assess endometrial receptivity to inform pregnancy and individualized clinical management strategies.
Hyperbaric Oxygen Therapy in Systemic Inflammatory Response Syndrome
Authors: Gouveia Débora , Chichorro Mariana , Cardoso Ana , Carvalho Carla , Silva Cátia , Coelho Tiago , Dias Isabel , Ferreira António , Martins Ângela
Published: January 2022

(1) Background: Systemic inflammatory response syndrome (SIRS) can occur due to a large number of traumatic or non-traumatic diseases. Hyperbaric oxygen therapy (HBOT) may be used as a main or adjuvant treatment for inflammation, leading to the main aim of this study, which was to verify the applicability of HBOT as a safe and tolerable tool in SIRS-positive dogs. (2) Methods: This prospective cohort study included 49 dogs who showed two or more parameters of SIRS, divided into the Traumatic Study Group (n = 32) and the Non-Traumatic Study Group (n = 17). All dogs were submitted to HBOT for 60–90 min sessions, with 2.4–2.8 ATA. (3) Results: This study revealed that 73.5% (36/49) of dogs showed improvement, and the minimum number of HBOT sessions was two, with a mean of 12.73. The number of days between diagnosis and the beginning of HBOT showed statistical significance (p = 0.031) relative to the clinical outcome. No dogs showed any major side effects. (4) Conclusions: We concluded that HBOT may be safe and tolerable for SIRS-positive dogs, and that it should be applied as early as possible.
Direct Detection of Feline Coronavirus by Three Rapid Antigen Immunochromatographic Tests and by Real-Time PCR in Cat Shelters
Authors: Vojtkovská Veronika , Lukešová Gabriela , Voslářová Eva , Konvalinová Jarmila , Večerek Vladimír , Lobová Dana
Published: January 2022

The aim of this study was the direct detection of feline coronavirus by real-time PCR and by three different rapid immunochromatographic (RIM) tests detecting antigens in faecal samples of shelter cats. Based on sensitivity and specificity calculated for each of the RIM tests, the utility of RIM tests was compared. Seventy faecal samples originating from shelter cats housed in quarantine were examined. Out of 70 samples analyzed by real-time PCR, 44 (62.9%) were positive. Significantly more cats (p < 0.05) tested positive than negative. Neither age nor sex of the cats played a significant role (p > 0.05) in the shedding status of the virus. The sensitivity of the RIM tests was found to be at low (<35%; RIM tests A and C) to satisfactory level (>50%, RIM test B). The number of virus particles determined by real-time RT-PCR analysis did not significantly correlate with the results detected by any of the RIM tests (p > 0.05). The results of this study indicate that the use of rapid antigen RIM tests in routine screening of FCoV shedding status in shelter cats is limited due to the occurrence of a high number of false negative results.
Stochastic Assessment of Scour Hazard
Authors: Flores-Vidriales David , Gómez Roberto , Tolentino Dante
Published: January 2022

Scour is the most frequent cause of bridge collapses in Mexico. Bridges located along the Mexican Pacific coast are exposed to extreme rainfall originating from tropical storms and hurricanes. Such environmental phenomena trigger sediment loss, which is known as scour. If maintenance actions are not taken after scouring events, the scour depth increases over time until the bridge collapses. A methodology to estimate the scour hazard considering both the scour–fill interaction and the Monte Carlo simulation method is proposed. The general extreme value probability distribution is used to characterize the intensity of the scouring events, the lognormal distribution is used to characterize the sedimentation process (fill), and a homogeneous Poisson process is used to forecast the occurrence of both types of events. Based on the above, several histories of scour–fill depths are made; such simulations are then used to develop time-dependent scour hazard curves. Different hazard curves associated with different time intervals are estimated for a bridge located in Oaxaca, Mexico.
Comparative Effects of Sodium-Glucose Cotransporter 2 Inhibitors on Serum Electrolyte Levels in Patients with Type 2 Diabetes: A Pairwise and Network Meta-Analysis of Randomized Controlled Trials
Authors: Zhang Jingjing , Huan Yonghong , Leibensperger Mark , Seo Bojung , Song Yiqing
Published: January 2022

Key Points

The relative efficacy of each specific sodium-glucose co-transporter 2 inhibitor compared with the other in affecting electrolytes has rarely assessed in head-to-head trials.

The study aimed to maximize statistical power to summarize direct and indirect evidence using both pairwise and network meta-analyses.

Sodium-glucose co-transporter 2 inhibitors significantly increased serum magnesium and phosphate levels, supporting a class effect of sodium-glucose co-transporter 2 inhibition.

Background

Previous studies have reported that sodium-glucose co-transporter 2 (SGLT2) inhibitors (SGLT2is) affect levels of serum electrolytes, especially magnesium. This study aimed to integrate direct and indirect trial evidence to maximize statistical power to clarify their overall and comparative effects in patients with type 2 diabetes (T2D).

Methods

We systematically searched PubMed, EMBASE, CENTRAL, and ClinicalTrials.gov up to January 2021 to identify eligible randomized controlled trials (RCTs) of SGLT2is that reported mean changes in serum electrolytes, including magnesium, sodium, potassium, phosphate, and calcium. We performed both random-effects pairwise and network meta-analyses to calculate the weighted mean difference (WMD) and 95% confidence intervals (CI).

Results

In total, we included 25 RCTs involving 28,269 patients with T2D and 6 SGLT2is. Compared with placebo, SGLT2is were significantly associated with elevations in serum magnesium by 0.07 mmol/L (95% CI, 0.06 to 0.08 mmol/L) and serum phosphate by 0.03 mmol/L (95% CI, 0.02 to 0.04 mmol/L). Our network meta-analysis showed no evidence of significantly superior efficacy of any specific SGLT2 inhibitor over the others, although dapagliflozin was associated with a larger increment in serum magnesium (WMD=0.16 mmol/L) compared with other SGLT2is. Similarly, no statistically detectable differences among the effects of SGLT2is on serum levels of other electrolytes were detected.

Conclusions

SGLT2is significantly increased serum magnesium and phosphate levels, consistent with a class effect of SGLT2 inhibition. However, further investigations of long-term efficacy and safety in patients with T2D with different clinical phenotypes are needed.
Effect of Cyclophosphamide and Glucocorticoid Therapy in IgA Nephropathy: A Single-Center Retrospective Analysis
Authors: Beck Nicolas , Walz Gerd , Schneider Johanna
Published: January 2022

Key Points

Immunosuppressive therapy with cyclophosphamide combined with glucocorticoids improves kidney function, proteinuria, and hematuria.

Immunosuppressive therapy with cyclophosphamide combined with glucocorticoids is safe for infectious complications.

Background

IgA nephropathy (IgAN) is the most common primary glomerulonephritis in adults, which causes ESKD in ≤45% of patients in the long term. The optimal therapeutic approach remains undetermined. In this study, we report the results of a single-center retrospective analysis of patients with IgAN.

Methods

We retrospectively evaluated the therapeutic approach and outcome of all patients at our center with biopsy-proven IgAN between 2000 and 2020, focusing on the effect of intravenous cyclophosphamide therapy combined with glucocorticoids (“immunosuppressive therapy group”). The control group received standard supportive care.

Results

Patients in the immunosuppressive therapy group had worse kidney function before the initiation of therapy, as indicated by higher serum creatinine, more proteinuria, and a higher degree of hematuria than the control group; they also displayed a higher body mass index. The Oxford classification of IgA nephropathy (MEST-C score) suggested more inflammatory activity in the immunosuppressive therapy group, including more crescents and endocapillary hypercellularity. During the follow-up, proteinuria and hematuria decreased in both groups, and to a significantly greater extent in the immunosuppressive therapy group. Cyclophosphamide treatment significantly improved kidney function as determined by the fold-change of eGFR during the observation period. The number of infections and hospitalizations did not differ, but the incidence of diabetes was increased in the immunosuppressive therapy group.

Conclusions

This study suggests immunosuppressive therapy with cyclophosphamide combined with glucocorticoids improves kidney function, proteinuria, and hematuria. The therapy was safe for infectious complications, but was associated with an increased incidence of diabetes, which might be attributable in part to the use of steroids in patients with a higher body mass index at baseline. Although immunosuppressive therapy in IgAN remains controversial, our findings suggest that at least some patients benefit from more aggressive therapy.
RAYMOND WILLIAMS NO ESPAÇO DAS PRODUÇÕES DISCENTES NO ESTADO DE SÃO PAULO: USP, UNESP E UNICAMP (2004-2020)
Authors: Malandrin Hiago Vaccaro
Published: January 2022

Apresentaremos como, entre 2004 e 2020, a obra de Raymond Williams (1921-1988) ganha espaço nas produções discentes na USP, Unesp e Unicamp. Partindo da história da leitura de Franco Moretti, observamos como o movimento editorial dos anos 1970 que se ocupou de traduzir Williams também o colocou como referência para a área de humanidades no espaço universitário.
A OFERTA DE CICLOS DE LEITURA EM LÍNGUA INGLESA NA FORMAÇÃO CONTINUADA
Authors: Medeiros Lady Lourdes Soares , Almeida Jackson Santos Vitória de , Neves Maralice De Souza
Published: January 2022

Esta pesquisa parte de ações que promovem a leitura literária por meio da oferta de ciclos de mediação em língua inglesa em um projeto de extensão universitária. A conclusão é que a posição de mediador afeta o ensino-aprendizagem do docente.
LUTAS E RESISTÊNCIA DE UMA PROFESSORA AO MAGISTÉRIO NA ESCOLA JOSÉ DE ALENCAR -1982
Authors: Pereira da Costa Maria Clelia
Published: January 2022

Objetivo apresentar a resistência de professoras ao exercício do magistério. Embasado nos estudos de Michel Foucault (2003). A metodologia qualitativa com entrevista semiestruturada realizada com Marlene e Perla. Os resultados indicam diversos traços de empoderamento.  Palavras-Chaves: Resistência ao Magistério, Experiência de vida, Estudos foucaultianos
DE NOVO ESSA MESMA HISTÓRIA... UMA ANÁLISE DE REPRESENTAÇÕES DO LEITOR POPULAR NO PROGRAMA ‘CONTA PRA MIM’
Authors: Curcino Luzmara , Fancio Adriana Cicera Amaral
Published: January 2022

Analisa-se, neste trabalho, representações do leitor no programa de incentivo à literacia familiar “Conta pra Mim” (MEC, 2020). Com base, na Análise Discurso, observa-se, o excessivo didatismo das orientações e os falsos endereçamentos de público.
ANTROPOFAGIA E PARANGOLÉ NA TERRA DE MAKUNAIMA: VIVENDO E COMPARTILHANDO EXPERIÊNCIAS PLURAIS
Authors: Da Silva Ivete Souza
Published: January 2022

Antropofagia e parangolé na terra de Makunaima é uma proposição educativa que fez parte do V Festival Internacional de Teatro e Artes Performáticas (V FITAP), proposta pelo Grupo de Estudo e Pesquisa Cruviana: Educação, Arte e Intercultura. Realizada no Espaço Cultural “Casa do Neuber” localizado na cidade de Boa Vista, Estado de Roraima. A proposição faz referência a Antropofagia Cultural Brasileira ocorrida no Brasil na década de 1920, a série de obras Parangolé do artista plástico e performático Hélio Oiticica e ao Estado de Roraima na figura de Makunaima personagem da lenda indígena do povo Makuxi. Durante a proposição o público vivenciou uma experiência artística performática onde artistas convidados expuseram seus trabalhos e produziram junto com o público. A vivência provocou a construção de um outro espaço educativo onde a aprendizagem se deu a partir de espaços de compartilhamento e criação, movimentados pelos saberes, fazeres, memórias e afetos de cada pessoa lá presente. Malabaristicamente, apresentamos um canto dos nortes aos Brasis e um canto dos Brasis ao mundo, levando um pouco da educação e da arte que teimosamente fazemos
SOBRE FORMAR LEITORES E ESCRITORES EQUILIBRISTAS: DAS POSSIBILIDADES DO ESPAÇO-ESCOLA
Authors: Lazo Lara Jatkoske , Bacocina Eliane Aparecida
Published: January 2022

ResumoEste artigo traz observações da experiência de docência e pesquisa com leitura e escrita. Objetiva apresentar relatos de práticas de leitura, pela pesquisa narrativa/autobiográfica. Conclui-se: a leitura é um ato integralizador da percepção estética.Palavras-chave: literatura clássica e popular; saraus; formação e escola.AbstractThis article present observations of teaching and research experience with reading and writing. The objective is to present reports of reading practices, through narrative / autobiographical research. It concludes: reading is an act that integrates the aesthetic perception.Keywords: classic and popular literature; soirees; formation and school.ResumenEste artículo trae observaciones de la experiencia docente e investigadora con la lectura y la escritura. Tiene como objetivo presentar informes de prácticas lectoras, a través de investigaciones narrativas / autobiográficas. Concluye: la lectura es un acto que integran la percepción estética.Palabras clave: literatura clásica y popular; veladas; formación y escuela.
Studi Provenance Batupasir Karbonatan Formasi Kerek Dengan Metode Point Counting Di Daerah Kandangan Kabupaten Semarang
Authors: Rizki L. Muh. Fathur , Retongga Nofrohu , Oratmangun Andika Gerardus , Saputra Abdurrahman , Zahidah Atikah , Septiani Roos Diana , Bagus Abadi Rohmad , Lukas Watania Oan Marcello
Published: January 2022

Carbonate sandstone in the study area was found around rivers and hills in the study area. Provenance of sandstones in the research area of interest to be examined, because not known provenance the sandstone rock formations karbonatan Kerek especially in the research area. The purpose of this study was to determine the provenance of Kerek carbonated sandstones in the study area using themethod point counting. The methodology used for the analysis of Provenance in the study area is using petrographic incisions. The results of the analysis of provenance on the five samples of carbonated sandstones of the Kerek Formation in the study area obtained data in the form of: rock types including lithic arenite (Pettijohn, 1975), the climate of the source area is semiarid (Nelson, 2007), the source rock type is plutonic rock (Tartosa, et al, 1991). ) and its tectonic setting is in the magmatic arc transitional arc sub-zone (Dickinson and Suczek, 1979).
The Projection of Iran’s Healthcare Expenditures By 2030: Evidence of a Time-Series Analysis
Authors: Jahanmehr Nader , Noferesti Mohammad , Damiri Soheila , Abdi Zhaleh , Goudarzi Reza
Published: January 2022

Background: The projection of levels and composition of financial resources for the healthcare expenditure (HCE) and relevant trends can provide a basis for future health financing reforms. This study aimed to project Iran’s HCEs by the sources of funds until 2030. Methods: The structural macro-econometric modeling in the EViews 9 software was employed to simulate and project Iran’s HCE by the sources of funds (government health expenditure [GHCE], social security organization health expenditure [SOHCE], out-of-pocket [OOP] payments, and prepaid private health expenditure [PPHCE]). The behavioral equations were estimated by autoregressive distributed lag (ARDL) approach. Results: If there is a 5%-increase in Iran’s oil revenues, the mean growth rate of gross domestic product (GDP) is about 2% until 2030. By this scenario, the total HCE (THCE), GHCE, SOHCE, OOP, and PPHCE increases about 30.5%, 25.9%, 34.4%, 31.2%, and 33.9%, respectively. Therefore, the THCE as a percentage of the GDP will increase from 9.6% in 2016 to 10.7% in 2030. It is predicted that Iran’s THCE will cover 22.2%, 23.3%, 40%, and 14.5% by the government, social security organization (SSO), households OOP, and other private sources, respectively, in 2030. Conclusion: Until 2030, Iran’s health expenditures will grow faster than the GDP, government revenues, and non-health spending. Despite the increase in GHCE and total government expenditure, the share of the GHCE from THCE has a decreasing trend. OOP payments remain among the major sources of financing for Iran’s HCE.
Utility of the Right to Health for Addressing Skilled Health Worker Shortages in Low- and Middle-Income Countries
Authors: Yakubu Kenneth , Abimbola Seye , Durbach Andrea , Balane Christine , Peiris David , Joshi Rohina
Published: January 2022

Background: As a fundamental human right, the right to health (RTH) can influence state actors’ behaviour towards health inequities. Human rights advocates have invoked the RTH in a collective demand for improved access to essential medicines in low- and middle-income countries (LMICs). Similarly, scholars have used the RTH as a framework for analysing health problems. However, its utility for addressing skilled health worker (SHW) shortages in LMICs has been understudied. Realising that SHW shortages occur due to existing push-and-pull factors within and between LMICs and high-income countries (HICs), we sought to answer the question: "how, why, and under what circumstance does the RTH offer utility for addressing SHW shortages in LMICs?" Methods: We conducted a realist synthesis of evidence identified through a systematic search of peer-reviewed articles in Embase, Global Health, Medline (Ovid), ProQuest – Health & Medical databases, Scopus (Elsevier), Web of Science (Clarivate), CINAHL (EBSCO), APAIS-Health, Health Systems Evidence and PDQ-EVIDENCE; as well as grey literature from Google Scholar. Results: We found that the RTH offers utility for addressing SHW shortages in LMICs through HIC state actors’ concerns for their countries’ reputational risk, recognition of their obligation to support health workforce strengthening in LMICs, and concerns for the cost implication. State actors in LMICs will respond to adopt programs inspired by the RTH when they are convinced that it offers tangible national benefits and are not overly burdened with ensuring its success. The socio-economic and institutional factors that constrain state actors’ response include financial cost and sustainability of rights’-based options. Conclusion: State and non-state actors can use the RTH as a resource for promoting collective action towards addressing SHW shortages in LMICs. It can also inform negotiations between state actors in LMICs and their HIC counterparts.
Knowledge About HIV/AIDS and Its Transmission and Misconception Among Women in Bangladesh
Authors: Bhowmik Jahar , Biswas Raaj Kishore
Published: January 2022

Background: Asian and pacific region countries are high risk countries for human immunodeficiency virus/ acquired immune deficiency syndrome (HIV/AIDS). Although the prevalence of HIV/AIDS is low in Bangladesh but women in Bangladesh have been identified as susceptible due to associated socioeconomic exposures. There are various misconceptions associated with HIV/AIDS transmission among the women in low- and middle-income countries including Bangladesh, which lead to a negative attitude towards the HIV/AIDS-infected. The purpose of this study was to assess the overall knowledge, transmission, and misconception about HIV/AIDS among the women in Bangladesh as well as its spatial distribution across the country. Methods: The study used data from the UNICEF (United Nations Children’s Fund) Multiple Indicator Cluster Survey (MICS) 2019, with a sample of 64 346 women. This was a cross-sectional, population-based survey of Bangladeshi women aged 15–49 conducted using a multistage, cluster sampling technique. Three binary outcome variables considered were knowledge about HIV/AIDS, knowledge about HIV/AIDS transmission and knowledge on myths and misconceptions on HIV/AIDS along with 10 predictors based on past literature. Bivariable analysis using chi-square tests of association was conducted to examine the unadjusted percentage differences of the outcome variables for each of the predictor variables and their associations. Multiple binary logistic regression models were then fitted to evaluate the association between the outcome variables and the predictors after adjusting for survey cluster, strata, and weights. All analysis was conducted in R software (V 2.5.0). Results: The percentage of women who held knowledge about HIV/AIDS, knowledge about HIV/AIDS transmission and knowledge on misconceptions about transmission of HIV were on average 60.3%, 52.2% and 71.7% respectively. The models indicated that women regularly exposed to media were 79%, 18% and 19% significantly more likely (odds ratio, OR: [95% CI] = 1.79: [1.70, 1.89]; 1.18: [1.10 1.26] and 1.19: [1.11, 1.27]) to have heard about HIV, aware about HIV transmission, and have less misconceptions about HIV respectively compared to those who were not exposed to media. Overall results indicate that women from peripheral districts living far from metropolitan cities were most unaware of HIV and had higher misconceptions about AIDS. Conclusion: The findings of this study should assist policy-makers and program implementers to focus on raising awareness to educating women about how HIV/AIDS is transmitted. Furthermore, interventions should be made by targeting the most disadvantaged groups, including younger women with low education living in rural areas, from poor households and limited access to information. Also, education on HIV transmission in Bangladesh should integrate cultural and ethnic considerations of HIV/AIDS.
MODERN TYPES OF PRODUCTION AND PRODUCTS BASED ON INTELLECTUAL CAPITAL
Authors: Selyanin O.
Published: January 2022

Currently the scientific community distinguishes several types of production and product based on intellectual capital. Most used are intelligent production and product, knowledge-intensive, innovative, high-tech and smart manufacturing and product. These terms were introduced a long time ago but their precise definitions still do not exist and the boundaries between them are rather arbitrary. This paper is devoted to the analysis and systematization of definitions of the concepts of science-intensive, innovative, high-tech and intellectual production and product represented in scientific issues in order to distinguish their key characteristics, compare and designate their relationship. It was found each of the concepts has at least 2 approaches to the definition and as a rule one of which reflects its consistency. The relationship between each of the types of production and the product has been determined. The system of relationships has a hierarchical structure: high-tech manufacturing and product are the subset of innovative, those are the subset of knowledge-intensive, and those are the subset of intelligent. Smart manufacturing appears to be a special characteristic. The results of this work can be used as a basis for the development of more accurate definitions of the concepts under consideration in the scientific community, their unification in scientific researches and legislative acts.
ORGANIZATION OF REMOTE WORKPLACES AT ENTERPRISES DURING THE PANDEMIC: RESULTS OF AN EMPIRICAL STUDY
Authors: Apenko S. , Malyshev Artem
Published: January 2022

In the context of the pandemic, the number of remote jobs has increased significantly. Many organizations have faced both difficulties and advantages of remote employment. The problematic aspect is the organization of remote workplaces. Despite the fact that there are quite a large number of scientific publications by Russian and foreign authors devoted to remote employment, today there is a shortage of research on various issues of remote workplace organization. In this regard, the purpose of the proposed study is to study the state of the organization of remote workplaces in Russian companies, taking into account the changes associated with the spread of a new coronavirus infection. The research methods were the analysis of secondary data posted on the websites of popular job search services and large analytical centers; a questionnaire survey at enterprises in various fields of Omsk. A total of 343 remote employees and 144 managers took part in the questionnaire survey. The main results of the study were the study of the advantages of remote employment and the problems of organizing remote workplaces. Among the problems, the problems of organizing communications between remote employees and their managers, equipping workplaces, and workplace planning have been studied in more depth. It was also revealed the employees' installations to work in a remote format in the future. The main conclusion was the recorded tendency to increase the scale and diversity of problems in the organization of remote workplaces due to uncontrolled processes of transition to remote employment.
Effects of Betaine Supplementation to Broiler Diets Under Heat Stress
Authors: KONCA Yusuf , BÜYÜKKILIÇ BEYZİ Selma
Published: January 2022

Betaine is an osmoregulatory substance obtained from some natural plant materials such as sugar beet, regulating intracellular biochemical events by attracting water. Due to this important function of betaine in water balance, it may play an important role in maintaining the body water balance of birds under heat stress. On the other hand, since betaine is a good methyl donor, some essential nutrients such as methionine and choline can be saved in the diet, or they can serve as complementary substances in the deficiency of these nutrients. Previous studies have shown that the addition of betaine can make significant contributions to the nutrition of broiler chickens in heat stress situations. The effects that may occur, especially when the body needs methyl groups, may be more pronounced. Dietary betaine supplementation increases live weight gain and breast muscle efficiency, improves feed efficiency and reduces fat content in broilers. The osmoregulatory function of betaine, immune system disorders, low immune strength, reducing respiratory alkalosis, oxidative stress and intestinal microbiome changes caused by heat stress. In this study, some evaluations were made in terms of the use of betaine in broiler diets to meet the performance and physiological needs of animals.
Monthly Average Wind Speed Forecasting in Giresun Province with Fuzzy Regression Functions Approach
Authors: YILDIRIM Abdullah , BAŞ Eren
Published: January 2022

In recent years, fuzzy inference systems have been used as an effective method for forecasting problems instead of classical time series methods. Fuzzy inference systems are based on fuzzy sets and use membership values as well as the original data. The fuzzy regression functions approach, which is one of the popular fuzzy inference systems, has different importance from many fuzzy inference systems with its features that it does not have a rule base and is easier to apply, unlike many fuzzy inference systems in the literature. In this study, both the monthly average wind speed forecasting of Giresun Province is performed for the first time in the literature and the fuzzy regression functions approach method is used for the first time in the literature for wind speed forecasting. To evaluate the performance of the fuzzy regression functions approach used to forecast monthly average wind speed in Giresun Province, the results obtained from many methods suggested in the literature for forecasting problems are compared. As a result of the evaluations, it is concluded that the forecasts obtained by the fuzzy regression functions approach are superior than some other methods in the literature.
Mengejar dan Melupakan Kebahagiaan dalam Perspektif Zhuangzi
Authors: Lie Agustinus
Published: January 2022

The search of happiness often misleads people to objectify happiness itself. In Zhuangzi's philosophical view, happiness is a state of continuous flow in an endless process. If one is immersed in the process, happiness itself will appear in the state of oblivion. He will forget his starting point, flow like the wind, and will not pay attention to the end of the process or the set goal. He will join in the process, forget about himself, and forget everything around him. Through oblivion, one will be free to roam without anyone getting in his way. Zhuangzi uses humorous and lively stories to lead every reader to seek and afterward forget happiness. A paradoxical condition arises here. Forgetting happiness is a way to reach deeper happiness
Allah Harapan Kita di Masa Krisis Pandemi Covid-19
Authors: Bala Kristoforus
Published: January 2022

The current Covid-19 pandemic has led to existential crises throughout the whole world. It has affected many aspects of human life. It has caused fear, anxiety, despair and even death of millions of people. This article focuses on the importance and meaningfulness of hope in God in the midst of the Covid-19 crisis. In Christian theology, hope is one of the theological virtues. It has become increasingly important and urgent for Christians and theologians to reflect on hope in God as the ultimate source of hope for humankind in such a time like this. In the midst of the widespread of various misinterpretations of the Covid-19 pandemic, Christians and theologians are called to contribute their theological reflections for the betterment of individuals, societies and humanity at large especially in coping with and responding to the pandemic crisis. The method applied in this article is qualitative, i.e. by studying in depth biblical sources, magisterial documents and Catholic teaching on theme of hope in God as a theological virtue and other sources that are related to the topic of the Covid-19 pandemic.
Peran Status dan Modal Sosial dalam Penyembuhan dari Covid-19
Authors: Dwintarto Paulus
Published: January 2022

In this article, the author reflects on his experience as a survivor of COVID-19, employing a sociological concept, namely social capital. The author was infected with the covid-19 virus while studying, precisely while working on his thesis, at St. John's University, New York. Suffering from illness, in this case due to COVID-19, in a foreign country was already a difficult experience. The situation was even worse because at that time, medical personnel in the United States did not have adequate and reliable knowledge in dealing with COVID-19 since the pandemic had just entered the first wave. The author experienced the difficulty of getting access to hospital care because of the surge in the number of patients. The author recognized that his social status as a Catholic priest was an invaluable social capital in the process of his care and recovery from illness, such as enabling him to get access to hospital and gain moral, spiritual, and material supports from his social network
The Influence of Brand Image, Brand Ambassador and Price on Purchasing Decisions for Scarlett Whitening Product in Riau
Authors: Safika Elli , Raflah Wan Junita
Published: January 2022

This research aims to determine the influence and how much the influence of brand image, brand ambassador, and price on purchasing decisions for Scarlett Whitening Products in Riau partially and simultaneously. This research used quantitative methods. Data collection technique used online questionnaires and literature study with a sample of 97 people. The value of each independent variable is 2,888 for brand image; 2,135 for brand ambassador and 5,708 for price, meanwhile the value of t table is 1.986 that’s mean the brand image, brand ambassador, and price has significant and positive influence on purchasing decisions. The results of the coefficient of determination is 0,420 or 42%, which means the influence of the independent variable (brand image, brand ambassador, and price) on the dependent variable (purchasing decisions) is 42% while the remaining 58% is influenced by other factors not examined in this research.
STRATEGY ANLYSIS OF VILLAGE OWNED BUSINESS ENTITIES (BUMDES) IN IMPROVING THE COMMUNITY’S ECONOMY IN THE VILLAGE OF MADDANRENG PULU SUB-DISTRICT PATIMPENG
Authors: Saputra Asdar
Published: January 2022

This study aims to determine the strategy of Village Owned Enterprises (BUMDes) in improving the economy of the community in Maddanreng Village, Patimpeng Pulu District, Bone Regency. The population in this study were the community and the management of Village Owned Enterprises (BUMDes) Maddanreng Village, Patimpeng Pulu District, Bone Regency. The data collection techniques are carried out by literature, documents, interviews and observations. Data analysis techniques are reduction, data presentation and conclusion drawing. The results of the study show that: 1) The presence of BUMDes has made it easier for the people of Maddanreng Pulu Village, especially the farmers in the village, whose harvests they used to harvest sometimes often fail due to lack of knowledge to deal with pests, now they can harvest better than previous years. Because of the socialization and training on pests provided by the BUMDes management on how to choose seeds and plant them properly in order to produce good quality. 2) The role of BUMDes has proven to be very good, this can be seen from its role in providing easy access for the community to obtain business capital. with a very easy procedure and also eased because of the gradual payment system. So that it can overcome poverty in Maddanreng Pulu village even though this BUMDes Maddanreng Pulu has only been operating for 2 years and only has several business units and savings a
DESAIN JEMBATAN SUNGAI MESKOM MENGGUNAKAN GIRDER PRATEGANG
Authors: Al Ikhsan Al Ikhsan , Pribadi Juli Ardita , Puluhulawa Ndriyani
Published: January 2022

Jembatan sungai Meskom awalnya merupakan jembatan balok T yang menghubungkan permukiman  masyarakat setempat. Kondisijembatan tersebut saat ini memiliki pilar yang terlalu banyak yang berada dibawah  balok T sehingga perahu-perahu  nelayan tidak bisa melintasdibawah jembatan. Sehingga dicoba mendesain ulang jembatan tersebut menggunakan girder beton prategang. Dengan menggunakan girder prategangdiharapkan, sungai nantinya bisa difungsikan  bagi  masyarakat setempat dan perahu nelayan bisa melintas dibawah jembatan. Untuk analisa bebanmengacu pada standar pembebanan untuk jembatan SNI 1725-2016, dan SNI T-12-2004 untuk perencanaan struktur jembatan beton prategang.Desain meliputi Girder, diafragma, trotoar, slab. Hasil dari Desain yaitu lebar Slab jembatan 8 m, tebal 0,2 m, momen ultimit pada tumpuan 85,853kN, tulangan lentur negatif dan positif sama, yaitu Tulangan pokok D 16 – 100, tulangan bagi D 13 – 120.. Girder prategang menggunakan PCI girderdengan spesifikasi tinggi 0,9 m, beam spacing 2 m, mutu beton girder k-800. Kabel prestress pada desain PCI girder digunakan 4 tendon yang masing – masing terdiri dari 19 kawat jenis uncoated 7 wire super strands ASTM A-416 grade 270.Gaya prategang awal 5442,998 kN, gaya yang terjadiakibat jacking 4802,645 kN, dan gaya prategang akhir diperkirakan kehilangan tegangan (loss of prestress) 30% yaitu 3810,09 kN.
ABU KULIT PINANG SEBAGAI PENGGANTI FILLER PADA CAMPURAN AC-BC
Authors: Utami Andika , Sastra Marhadi , Zulkarnain Zulkarnain
Published: January 2022

AbstrakAC-BC merupakan salah satu bagian dari lapis perkerasan yang berfungsi sebagai lapis antara yang menahan beban maksimum akibat beban lalu lintas. Bahanperkerasan campuran AC-BC terdiri dari agregat kasar, agregat halus, bahan pengisi (Filler) dan aspal. Penelitian ini merupakan eksperimen untuk mencarialternatif   pengganti   filler   dengan   memanfaatkan   limbah   abu   kulit   pinang   karena semakin meningkatnya harga material menjadi kendala dalammewujudkan pembangunan jalan aspal beton yang lebih layak. Dalam menanggapi hal ini perlu dipikirkan suatu bahan pengganti yang dapat diperoleh denganmudah serta diproduksi misalnya memanfaatkan limbah kulit pinang sebagai filler campuran beton aspal. Tujuan dan manfaat penelitian ini adalah untukmengetahui karakteristik campuran AC-BC dengan abu pinang sebagai filler melalui pengujian marshall sehingga diketahuinya nilai Stabilitas, VIM, VMA,VFWA, Flow, MQ. Aspal yang digunakan adalah aspal pen 60/70, berdasarkan hasil pengujian didapat kadar aspal yaitu 5,0% dengan variasi campuran abupinang 0%, 25%, 50%, 75% dan 100%. Untuk komposisi agregat untuk AC-BC  :  agregat  kasar  60,5%,  agregat  halus  33,5%. Hasil  pengujian  abu  kulitpinang  sebagai  berikut  : Stabilitas (kg) = 3517,91> 800, VIM (%) = 4,20 >3-5%, VMA (%) = 14,26>14, VFWA (%) = 70,77>63, Flow (mm) = 2,50> 2-4,Density = 2,32 MQ (kg) = 1462,63>250.
PENGARUH ASPEK RASIO H/W TERHADAP KONDISI LINGKUNGAN TERMAL DI DAERAH PESISIR
Authors: Rahman Boby , Enda Dedy , Febriani Oni
Published: January 2022

Pusat kota Selatpanjang mengalami peningkatan dari segi fungsi kawasan. Peningkatan tersebut menyebabkan munculnya bangunan-bangunan dengan ketinggian berbeda sehingga memiliki dampak tidak adanya ruang yang cukup di dalam proses pelepasan panas melalui aliran udara. Dari fenomena tersebut, penelitian ini mencoba mengevaluasi pengaruh perubahan ketinggian bangunan berbanding lebar jalan (H/W) terhadap kinerja lingkungan termal dengan berpedoman kepada peraturan Ditjen Cipta Karya dan peraturan pemerintah kota Selatpanjang. Penelitian ini merupakan penelitian eksperimental menggunakan simulasi software ENVI-met V3.1. Hasil penelitian menunjukkan desain canyon dengan nilai H/W rendah (1.05 dan 0.9) menghasilkan temperatur udara sebesar 34,7°C dan 35,4°C. Terdapat selisih 1-2.4°C lebih tinggi jika dibandingkan desain canyon dengan nilai H/W tinggi. Sementara itu desain canyon bangunan didalam kondisi diterapkannya peraturan Ditjen Cipta Karya (2000), shallow canyon (H/W rendah) tetap menghasilkan nilai temperatur udara yang lebih tinggi jika dibandingkan deep canyon (H/W tinggi) namun dengan selisih nilai yang kecil yaitu 0.1°C-0.37°C.
DESAIN JEMBATAN JALAN DATUK LAKSAMANA DENGANT-GIRDERMENGGUNAKANSNI 1725-2016
Authors: Ahmadi Fahrul , Puluhulawa Indriyani
Published: January 2022

Jembatan Jalan Datuk Laksamana dengan panjang 20 m dan lebar 3 m, yang menghubungkan antara Desa Bukit Batu dan Desa Sukajadi Kecamatan Bukit Batu merupakan jembatan beton bertulang dengan lantai kayu yang mengalami kerusakan, diantaranya pada balok yang keropos/retak dan lantai jembatan yang mengalami pelapukan. Untuk itu direncanakanlah struktur atas jembatan dengan tipeT-Girder, yang mengacukepadaSNI1725-2016 tentang pembebanan untukjembatandanSNIT-12-2004tentangperencanaanstrukturbeton untukjembatan.Hasil desain, perhitungan plat lantai jembatan diperoleh dimensi tulangan utama D16 - 200 mm dan tulangan bagi D13 - 300 mm.Slab trotoar diperoleh tulangan  pokok D16 - 200 mm, dan tulangan longitudinal D13- 400 mm. Dinding railing diperoleh tulangan lentur 2ɸ12dan tulangan geserØ8 - 100 mm.Plat injak arah memanjang dan arah melintang diperoleh dimensi tulangan D16 - 200 mm. Balok girder untuk tulangan lentur diperoleh tulangan tarik 18D32 mm dan tulangan tekan 5D32, Sedangkan tulangan geser Ø12 - 100 mmdan tulangan badan diperoleh 8Ø12.Balok diafragma diperoleh tulangan tarik dan tulangan tekan sama 3D16, Sedangkan tulangan geser Ø12 - 150 mm dan tulangan badan diperoleh 2Ø12 mm. Sementara itu untuk perletakan diperoleh dimensi 440 mm x 400mm x 129 mm.
PENENTUAN JENIS TIKUNGAN DAN GEOMETRIK JALAN (STUDI KASUS: JALAN KAYU API KUALA PENASO, KECAMATAN TALANG MUANDAU)
Authors: Ruslan Ruslan , Idham Muhammad
Published: January 2022

JalanKayuApi Kuala Penaso, kecamatanTalangMuandau, KabupatenBengkalisadalahRuasjalan yang menghubungkandariDesaBeringinkeIbu Kota Kecamatan, dengan kondisijalanlurusdansertamemilikibeberapatitiktikungan yang tajam. DalamPerencanaangeometriadatiga point pentingyaitualinyemen horizontal (trasejalan), alinyemenvertikal (penampangmemanjangjalan),danpenampangmelintangjalan; sehinggadapatmenghasilkanbentukjalan yang dapatdimanfaatkanuntukoperasilalulintasdengancepat, lancar, aman, nyaman, danefisien.Sehubungan dengan masalah ini, perludilakukanpengkajianulangterhadaptikungan yang berada pada lokasi tersebut. Adapuntujuandariperencanaaniniuntukmengetahuijenistikunganpadalokasisesuaidenganmetode TPGJAK 1997.Ada 43 tikungandengan 38 Spiral - Lingkaran - Spiral (S-C-S) dan 5 Spiral - Spiral (S-S).DimanaLc>Lcmin (Lcmin = 25 m), sehinggatermasuk spiral – circle – spiral. Dimana R <RmindanLcRminbaikuntuklalulintaskendaraan.
METODE PELAKSANAAN PEKERJAAN JALAN (STUDI KASUS : JALAN PAMBANG – TELUK LANCAR STA 1+600 – STA 3+100)
Authors: Nizam M. Khairun , Sastra MArhadi
Published: January 2022

Jalan merupakan prasarana utama yang sangat berpengaruh dalam bidang perekonomian di suatu daerah. Ruas jalan Pambang – Teluk Lancar, Kecamatan Bantan, Provinsi Riau, merupakan jalan penghubung utama ke beberapa desa diujung pulau Bengkalis.Kondisi jalan saat ini dalam keadaan rusak dan kurang memadai untuk lalu lintas masyarakat. Oleh karena itu pemerintah daerah melalui dinas Pekerjaan Umum telah melakukan perencanaan jalan pada lokasi tersebut, yang rencananya akan di lanjutkan dengan pelaksanaan pekerjaan konstruksi pada tahun 2020.Dalam perancangan metode ini didapat tata cara pelaksanaan pekerjaan secara umum dari awal hingga akhir pekerjaan berdasarkan spesifikasi yang telah disyaratkan. Kemudian lokasi quarry yang digunakan adalah quarry yang sudah ada permanen di dekat lokasi pekerjaan dengan jarak ± 5 km dari lokasi pekerjaan. Untuk penempatan barak pekerja dan kantor lapangan juga memakai yang sudah ada atau permanen di sekitaran lokasi quarry.
DESAIN JEMBATAN KOMPOSIT PADA SUNGAI JALAN ANTARA RUPAT UTARA
Authors: Amri Syahrul , Puluhulawa Indriyani
Published: January 2022

Jembatan adalah bagian dari sistem transportasi nasional yang  mempunyai  peranan penting. Jembatan yang terletak pada Sungai Jalan Antara awalnya adalah jembatan kayu. Dikarenakan kondisi Jembatan ini sudah mengalami kerusakan terutama pada bagian lantai, maka direncanakan menggunakan jembatan dengan jenis struktur komposit. Perencanaan ini telah dilakukan analisis beban yang mengacu pada Standart Pembebanan untuk Jembatan RSNI T-02-2005 dan untuk perencanaan struktur baja jembatan SNI T-03-2005. Tahapan perencanaan diawali dengan penentuan dimensi girder, elastomer bearing, diafragma, lantai, trotoar, tiang sandaran, dan plat. Hasil yang diperoleh yaitu tulangan utama slab D13-200. Profil girder baja menggunakan baja WF900×300×16×28 mm dengan jarak antar girder 1,5 m. Penambahan cover plate 300×10mm pada tengah bentang sepanjang 15 m, dan diafragma baja WF 500×200×10×16 mm dengan jarak antar diafragma 5,5 m.