bluuebunny/crossref_metadata_2025 huggingface dataset:
TECHNOLOGY PURCHASE, IN-HOUSE R&D, AND PATENTING: AN EMPIRICAL ANALYSIS OF FIRMS IN HIGH- AND MEDIUM-TECHNOLOGY INDUSTRIES IN INDIA
Authors: DANISH MOHAMMAD , DHANORA MADAN , HARISH M. D.
Published: February 2023

This study examines the relationship between technology purchase, in-house R&D, and patenting activities of firms in India’s high- and medium-technology industries. The study is divided into two periods, i.e., 1995–2005 and 2006–2015, based on the pre- and post-product patent amendment1act, 2005. We employ a negative binomial model with fixed and random effects to estimate the impact of technology purchase over R&D and patenting activity, respectively. The estimates of the R&D equation suggest a complementary relationship between technology purchase and in-house R&D. However, the estimates of the patents equation suggest a substitute relationship between in-house and technology purchase. Further, we find an inverted U-shaped relationship between in-house R&D, technology purchase, and patenting activities. However, the interaction between in-house R&D and technology purchase positively moderates the nonlinear relationships. Lastly, our estimated result is sensitive to different industries and periods.1The product patent amendment act came into effect with The Agreement on Trade-Related Aspects of Intellectual Property Rights (TRIPs-2005) in India.
Distribution and attribute analysis of soil selenium in Hebei Province, China
Authors: Zhang Liting , Xie Weiming , Yu Wenlong , Zhang Li , Zhang Shicong , Wang Xi , Xie Xiaoyang , Cheng Hangxin
Published: February 2023

From 2004 to 2018,
c.
73% of the land area in Hebei Province was surveyed by a 1:250 000 land quality geochemical survey of the National Geochemistry Survey of Land Quality. Based on the topsoil (0–20 cm) datasets (50 724 analysis samples) and attribute analysis of the key area with a semivariance function model, geographic detector model and random forest model, the content and spatial distribution of soil selenium (Se) in Hebei Province and the influencing factors of the distribution of Se in the Shijiazhuang–Xingtai–Handan area were obtained. The soil Se content in Hebei Province is low, ranging from 0.02 to 3.23 mg kg
–1
, with an average of 0.20  mg kg
–1
. The spatial distribution of soil Se was heterogeneous, and the marginal Se (0.125–0.175  mg kg
–1
) area and the sufficient Se (0.175–0.40  mg kg
–1
) area were widely distributed, but the acreage of the Se-rich (0.40–3.0  mg kg
–1
) area was very limited, accounting for only 2.43% of the total survey area. However, the Shijiazhuang–Xingtai–Handan area was a significant Se enrichment area. The spatial distribution of Se in this area was restricted by natural and socioeconomic factors. Soil organic matter was the most influential factor and showed good coordination with Se. Coal burning superimposed on natural factors promotes the spatial differentiation of soil Se to a certain extent.
Combined effects of porosity and degree of saturation on the mechanical properties and deformation behaviour of rocks
Authors: Pan Yue , Wu Guang , He Liu , Zhao Zhiming
Published: February 2023

To reveal the roles of pores and fissures in the rock-weakening effect of water, this study used porosity to quantitatively characterize pores and fissures in rocks. Based on the results from mechanical tests on rock specimens with different porosities and degrees of saturation, the combined effects of the porosity and water content on the mechanical properties and deformation behaviour of rocks were investigated. The test results indicated that the rock-weakening effect of water was markedly more significant if the pores and fissures in the rock were highly developed. The test data showed that the ratio of saturated specimen strength/dry specimen strength of porous rock can be even lower than 0.1. The least-squares regression method was used to derive the impact of rock porosity on rock weakening due to the effect of water. Based on the results, a practical engineering method for modifying the mechanical parameters of wet rocks with highly developed pores and fissures was proposed. This method can be used to calculate the stress–strain state of rocks more accurately.
A Carboniferous apex for the late Paleozoic icehouse
Authors: Griffis N. , Mundil R. , Montañez I. , Le Heron D. , Dietrich P. , Iannuzzi R.
Published: February 2023

Icehouse climate systems occur across an abbreviated portion of Earth history, constituting
c.
25% of the Phanerozoic record. The Late Paleozoic Ice Age (LPIA) was the most extreme and longest lasting glaciation of the Phanerozoic and is characterized by periods of acute continental-scale glaciation, separated by periods of ice minima or ice-free conditions on the order of <10
6
years. The late Paleozoic glaciogenic record of the Paraná and Kalahari basins of southern Gondwana form one of the largest, best-preserved and well-calibrated records of this glaciation. In the Carboniferous, the eastern and southern margins of the Paraná Basin and the Kalahari Basin were characterized by subglacial conditions, with evidence for continental and upland glaciers. In the latest Carboniferous, these basins transitioned from subglacial reservoirs to ice-free or ‘ice distal‘ conditions evidenced by the widespread deposition of marine deposits juxtaposed on subglacial bedforms. High-precision U–Pb zircon chemical abrasion thermal ionization mass spectrometry geochronological constraints from volcanic ash deposits in the deglacial marine black shales of the Kalahari Basin and from fluvial and coal successions, which overlie marine deposits in the Paraná Basin, indicate subglacial evidence in these regions is constrained to the Carboniferous. The loss of ice in these regions is congruent with a late Carboniferous peak in
p
CO
2
and widespread marine anoxia in the late Carboniferous. The permeant retreat of glaciers in basinal settings, despite an early Permian
p
CO
2
nadir, highlights the influence of short-term perturbations on the longer-term CO
2
record and suggests an ice threshold had been crossed in the latest Carboniferous. A definitive driver for greenhouse gases in the LPIA, such as abundant and sustained volcanic activity or an increased biological pump driven by ocean fertilization, is unresolved for this period. Lastly, the proposed Carboniferous apex for the high-latitude LPIA record is incongruent with observations from the low-latitude tropics where an early Permian peak is proposed.
ZNSwap: un-Block your Swap
Authors: Bergman Shai , Cassel Niklas , Bjørling Matias , Silberstein Mark
Published: February 2023

We introduce
ZNSwap
, a novel swap subsystem optimized for the recent Zoned Namespace (ZNS) SSDs. ZNSwap leverages ZNS’s explicit control over data management on the drive and introduces a space-efficient host-side Garbage Collector (GC) for swap storage co-designed with the OS swap logic. ZNSwap enables cross-layer optimizations, such as direct access to the in-kernel swap usage statistics by the GC to enable fine-grain swap storage management, and correct accounting of the GC bandwidth usage in the OS resource isolation mechanisms to improve performance isolation in multi-tenant environments. We evaluate ZNSwap using standard Linux swap benchmarks and two production key-value stores. ZNSwap shows significant performance benefits over the Linux swap on traditional SSDs, such as stable throughput for different memory access patterns, and 10× lower 99th percentile latency and 5× higher throughput for
memcached
key-value store under realistic usage scenarios.
Bounded-Degree Plane Geometric Spanners in Practice
Authors: Anderson Frederick , Ghosh Anirban , Graham Matthew , Mougeot Lucas , Wisnosky David
Published: February 2023

The construction of bounded-degree plane geometric spanners has been a focus of interest since 2002 when Bose, Gudmundsson, and Smid proposed the first algorithm to construct such spanners. To date, 11 algorithms have been designed with various tradeoffs in degree and stretch-factor. We have implemented these sophisticated spanner algorithms in
C
++
using the
CGAL
library and experimented with them using large synthetic and real-world pointsets. Our experiments have revealed their practical behavior and real-world efficacy. We share the implementations via
GitHub
for broader uses and future research.

We design and engineer
EstimateStretchFactor
, a simple practical algorithm, which can estimate stretch-factors (obtains lower bounds on the exact stretch-factors) of geometric spanners—a challenging problem for which no practical algorithm is known yet. In our experiments with bounded-degree plane geometric spanners, we found that
EstimateStretchFactor
estimated stretch-factors almost precisely. Further, it gave linear runtime performance in practice for the pointset distributions considered in this work, making it much faster than the naive Dijkstra-based algorithm for calculating stretch-factors.
Advanced glycation end products induce skeletal muscle atrophy and insulin resistance via activating ROS-mediated ER stress PERK/FOXO1 signaling
Authors: Du Haixia , Ma Yanpeng , Wang Xiqiang , Zhang Yong , Zhu Ling , Shi Shuang , Pan Shuo , Liu Zhongwei
Published: February 2023

In this study, we proposed a molecular mechanism underlying the skeletal muscle atrophy-associated insulin resistance in type 2 diabetes mellitus (T2DM). Our investigation suggests that exposure to AGEs, which are characteristic metabolites of T2DM pathology, induces the activation of reactive oxygen species (ROS)-mediated endoplasmic reticulum (ER) stress, leading to the upregulation of the protein kinase RNA-like ER kinase (PERK)/forkhead box O1 (FOXO1)/muscle atrophy F-box pathway and subsequent skeletal muscle atrophy, ultimately resulting in insulin resistance.
AI-Assisted Failure Location Platform for Optical Network
Authors: Liu Pengcheng , Ji Wei , Liu Qiang , Xue Xuwei
Published: February 2023

In the paper, we applied the customized AI module to the OTDR device and, combined with the optical power monitoring module, realized the AI-assisted optical network fault location mechanism for the high-density interconnection scenario of data centers. The mechanism can make full use of the data from optical links. Based on the link data, the AI module can predict the links that may fail, and then the target links will be monitored by the optical power module. The mechanism can quickly locate and respond to faulty links. Through the test, the introduction of an AI model can improve the average fault detection efficiency of the link by 98.41%.
Community Construction and Development Path Analysis of Ecological Environment-Friendly Elderly Care Service
Authors: Guo Jie , Li Wenjie , Ling Wenhao
Published: February 2023

As a new pension model, ecological pension is an important choice to relieve the pressure of population aging in China. This paper reviews the relevant literature on the integrated development of the ecological pension industry and rural revitalization in recent years and points out that the researchers have determined the model of the ecological pension industry, the path of rural revitalization, the comprehensive development of organic pension industry, and rural revitalization and the problems they face. Some results have been achieved. However, there is still a lot of research space for the integrated development of the ecological pension industry and rural revitalization, especially to establish a perfect index system of the ecological pension industry, the measurement standard of rural revitalization, and the theoretical basis and mechanism of integrated development. Regional cooperative symbiosis is based on industrial symbiosis. In terms of research methods, attention should be paid to the combination of theoretical analysis and empirical research, to the further development of this field, and to achieve remarkable results. In the process of social and economic development, the rural ecology can be built by solving the problems of the elderly, accurately reducing rural poverty, and protecting the environment. The healthy elderly care tourism destination has realized the integrated development of rural tourism, ecological health tourism, and elderly care tourism. Taking Chang’an District of Xi’an as an example, the advantages of the district in geographical location, climate, environment, tourism resource health, as well as the constraints in the system, talent, policy, and system are demonstrated, and the corresponding countermeasures are put forward.
Health Information Technologies in a Resource‐Limited Setting: Knowledge, Attitude, and Practice of Health Professionals
Authors: Mengestie Nebyu Demeke , Yeneneh Abraham , Baymot Asefa Birara , Kalayou Mulugeta Hayelom , Melaku Mequannent Sharew , Guadie Habtamu Alganeh , Paulos Genet , Mewosha Wondwossen Zemene , Shimie Aynadis Worku , Fentahun Ashenafi , Wubante Sisay Maru , Tegegne Masresha Derese , Awol Shekur Mohammed
Published: February 2023

The use of health information technology significantly enhances patient outcomes. As a result, policymakers from developing countries have placed strong emphasis on formulating eHealth policies and initiatives. However, there have not been many successful deployments to show for. The role of individual factors in the successful implementation of these technologies is indispensable. Therefore, this study assesses healthcare professionals’ knowledge, attitudes, and practice of health information technology. An institution‐based cross‐sectional study was conducted at the University of Gondar Comprehensive Specialized Hospital from November 15 to December 29, 2020. A structured, self‐administered questionnaire was used to collect data. Student’s t‐test was used to learn if there were any significant differences in practice habits between participants with and without previous information technology‐related training. In addition, first‐order partial correlation was conducted to identify the relationship of knowledge and attitude with practice. A total of 347 health professionals responded to the questionnaire, yielding an 87.2% response rate. Most health professionals are not aware of how to use health information technologies. Notably, practice levels were low and needed prompt action from responsible authorities. Previous training did not work very well to improve the practice levels of health professionals. However, the positive attitude of these professionals encourages policymakers and implementers to engage closely.
The Reality of Middle School (Intermediate) Female Students in Saudi Arabia and the Practice of 21st-Century Skills: Teachers’ Perspective
Authors: Alowayyid Norah Nasser Saleh
Published: February 2023

The skills that were considered necessary for success in the 21st century included the ability to improve social and intellectual abilities such as communication, cooperation, critical thinking, and problem-solving, as well as creativity and innovation. It also contains methods of working, interacting, cooperating, and working in teams so that they can encourage and support skills relevant to the 21st century, such as literacy, information technology, and digital networks. Thus, this study aims to know the reality of middle school (intermediate) pupils in the Kingdom of Saudi Arabia about putting the skills of the 21st century into practice. The researcher employed the descriptive survey approach in her work, and the study tool (questionnaire) was used on a random sample composed of middle school (intermediate) teachers (female) in the Al-Qassim region. The following are some of the major results of the study: The use of technology by the middle school (intermediate) female students efficiently and effectively garnered a high response rate from the study participants. However, the intermediate students’ skills in information, media and technology culture, health and safety skills, and self-leadership put into practice earned an average response rate from the study participants. There were statistically significant differences in the study, which favored higher education qualifications and the attendance of training courses relevant to the “skills of the 21st century,” with no statistically significant differences for the more years of experience. The study advised that material and moral motivation tactics should be utilized as it is of essential relevance and required for the leaders of schools to urge them on new leadership practices.
Same Day Biopsy and Treatment of Non-Melanoma Skin Cancer in Patients with Field Cancerization: A Retrospective Chart Study
Authors: Miles Jonathan , Luis-Gronau Camila , Cruzval-O’Reilly Estefania , Lugo-Somolinos Aida , Jolly Puneet S.
Published: February 2023

Background. Patients with field cancerization will develop numerous superficial non-melanoma skin cancers (NMSCs). Treating patients with field cancerization can be challenging and burdensome due to the numerous non-melanoma skin cancers (NMSCs) they develop and the frequent dermatology visits required for biopsy and treatment. Objective. The success rate of diagnosing and treating lesions suspicious for NMSCs on the same day is measured, immediately after biopsy. Methods. We retrospectively reviewed records of patients with same day lesion diagnosis and curettage treatment to determine diagnostic accuracy, treatment failure, and number needed to treat to reduce a follow-up treatment. Results. A total of 237 lesions underwent same day biopsy and treatment, of which the majority were NMSC (66%) or actinic keratosis (23%). Patients had at least 3 months and a median of 17 months follow-up. A total of 20 lesions either recurred or were deemed to require additional treatment. The number needed to treat (NNT) to prevent one follow-up treatment was 1.3. Limitations: sample size limited ability to determine risk factors for treatment failure. Conclusion. Simultaneous diagnosis and treatment of superficial NMSCs is a successful way of improving efficiency and patient satisfaction.
Inhibition of the MNK1/2–eIF4E Axis Augments Palbociclib-Mediated Antitumor Activity in Melanoma and Breast Cancer
Authors: Prabhu Sathyen A. , Moussa Omar , Gonçalves Christophe , LaPierre Judith H. , Chou Hsiang , Huang Fan , Richard Vincent R. , Ferruzo Pault Y. M. , Guettler Elizabeth M. , Soria-Bretones Isabel , Kirby Laura , Gagnon Natascha , Su Jie , Silvester Jennifer , Krisna Sai Sakktee , Rose April A. N. , Sheppard Karen E. , Cescon David W. , Mallette Frédérick A. , Zahedi Rene P. , Borchers Christoph H. , del Rincon Sonia V. , Miller Wilson H.
Published: February 2023

Aberrant cell-cycle progression is characteristic of melanoma, and CDK4/6 inhibitors, such as palbociclib, are currently being tested for efficacy in this disease. Despite the promising nature of CDK4/6 inhibitors, their use as single agents in melanoma has shown limited clinical benefit. Herein, we discovered that treatment of tumor cells with palbociclib induces the phosphorylation of the mRNA translation initiation factor eIF4E. When phosphorylated, eIF4E specifically engenders the translation of mRNAs that code for proteins involved in cell survival. We hypothesized that cancer cells treated with palbociclib use upregulated phosphorylated eIF4E (phospho-eIF4E) to escape the antitumor benefits of this drug. Indeed, we found that pharmacologic or genetic disruption of MNK1/2 activity, the only known kinases for eIF4E, enhanced the ability of palbociclib to decrease clonogenic outgrowth. Moreover, a quantitative proteomics analysis of melanoma cells treated with combined MNK1/2 and CDK4/6 inhibitors showed downregulation of proteins with critical roles in cell-cycle progression and mitosis, including AURKB, TPX2, and survivin. We also observed that palbociclib-resistant breast cancer cells have higher basal levels of phospho-eIF4E, and that treatment with MNK1/2 inhibitors sensitized these palbociclib-resistant cells to CDK4/6 inhibition. In vivo we demonstrate that the combination of MNK1/2 and CDK4/6 inhibition significantly increases the overall survival of mice compared with either monotherapy. Overall, our data support MNK1/2 inhibitors as promising drugs to potentiate the antineoplastic effects of palbociclib and overcome therapy-resistant disease.
Home Use of Mechanical Insufflation/Exsufflation in Adult Patients in Western Switzerland
Authors: Mitropoulou Georgia , Heinzer Raphael , Janssens Jean-Paul , von Garnier Christophe , Prella Maura
Published: February 2023

Background: Mechanical insufflation/exsufflation (MI-E) devices are often prescribed to patients with inefficient cough and recurrent infections, but their use in the home setting is not well characterized. Objective: The objective of this study was to report a real-life experience and identify factors that are associated with home MI-E use in adult patients. Methods: This is a cross-sectional observational study of adult subjects with neurological disease using MI-E at home for more than 3 months. Results: A total of 43 patients were included. Median age (interquartile range) was 48 (31–64) years. The most common diagnosis was muscular dystrophy (n = 15), followed by multiple sclerosis (n = 7) and amyotrophic lateral sclerosis (n = 7). 24 subjects (56%) reported using the MI-E at least once weekly. Based on device data downloads, the median objective use was 23% of days analysed (approximately 2 times per week). The vast majority (94%) of all participants reported using the device at least daily during an infectious episode, while 62% reported having used the device in emergency situations such as bronchoaspiration. Reported use correlated well with objective use (r = 0.82). Most subjects reported an improvement in their respiratory health (64%) and were satisfied with the device (78%). Higher reported and objective use were associated with increased symptoms (p = 0.001) and higher satisfaction with the device (p = 0.008). We found no association between frequency of use and baseline cough peak flow (CPF), bulbar impairment, non-invasive ventilation use, living environment, or supervised administration. Conclusion: Regular home MI-E use was associated with greater symptom burden and overall satisfaction with the device and was not influenced by baseline CPF. Patients without substantial bronchorrhea might not use the MI-E regularly but might still need to use the device at home during acute events. Therefore, familiarity with the MI-E via appropriate and repeated practical training is crucial.
A Longitudinal Assessment of the Natural Change in Haemoglobin, Haematocrit, and Mean Corpuscular Volume with Age
Authors: Goldberg Idan , Cohen Eytan , Gafter-Gvili Anat , Shochat Tzippy , Kugler Eitan , Margalit Ili , Goldberg Elad , Raanani Pia , Krause Ilan
Published: February 2023

Introduction: We aimed to assess the natural annual trends in the levels of haemoglobin, haematocrit, and mean corpuscular volume (MCV) in a population of adults, together with the influence of different clinical parameters on these trends. Methods: A retrospective analysis was carried out on data from a large cohort of subjects attending a screening centre in Israel. For each subject, the yearly average change of haemoglobin, haematocrit, and MCV was calculated. Statistical analysis was performed for the whole cohort and for different subgroups. Results: The study included 3,551 subjects. The average annual rates of decline were found to be −0.0550 g/dL (95% confidence interval [CI] −0.0590 g/dL to −0.0503 g/dL) and −0.097% (95% CI −0.112% to −0.083%) for haemoglobin and haematocrit, respectively. An average annual increase in the MCV level by 0.184 fL (95% CI 0.168 fL–0.200 fL) was found. Among men, the rate of decline in haemoglobin was found to be twice as high compared with women −0.06 g/dL versus −0.03 g/dL, respectively (p = 0.0063). In a multivariate analysis, gender remained the only parameter significantly associated with the annual decline of haemoglobin (p = 0.0001). Conclusion: An annual average decrease in the levels of haemoglobin and haematocrit together with an annual increase in MCV was found. These changes were more prominent in men.
Association between Hypokalemia and Albuminuria in a Japanese General Population
Authors: Toda Akiko , Hara Shigeko , Honda Ritsuko , Arase Yasuji
Published: February 2023

Introduction: Hypokalemia is associated with an increased risk of chronic kidney disease (CKD) and is a risk factor for mortality. Albuminuria is an early manifestation of CKD. We investigated the association between hypokalemia and the prevalence of albuminuria in a Japanese general population. Methods: We analyzed the data of 18,289 subjects who underwent annual health checkups in 2018. We categorized them into four groups according to their concentration of serum potassium (sK) and performed a multivariate logistic regression analysis to determine the association between hypokalemia and the prevalence of albuminuria in this population. Hypokalemia was defined as having an sK = 3.1–3.5 mEq/L. After dividing the subjects into those with/without renal dysfunction, those with/without hypertension, and those with/without hyperglycemia, we examined the association between hypokalemia and albuminuria in each group. Results: Compared to the subjects with sK = 4.1–4.5 mEq/L, the subjects with hypokalemia had a significantly high prevalence of albuminuria: multivariable-adjusted odds ratio (OR) = 2.70 (95% confidence interval [CI] 1.84–3.96). The subgroup analyses showed the following multivariable-adjusted ORs (95% CIs) of the subjects: without renal dysfunction, 3.08 (2.00–4.73); with renal dysfunction, 2.05 (0.89–4.69); without hypertension, 2.89 (1.36–6.16); with hypertension, 2.60 (1.67–4.04); without hyperglycemia, 2.49 (1.62–3.84); and with hyperglycemia, 3.55 (1.43–8.79). Conclusions: Hypokalemia was significantly associated with the high prevalence of albuminuria in general population. Regardless of the presence/absence of renal dysfunction, hypertension, or hyperglycemia, hypokalemia was positively associated with the prevalence of albuminuria, and the associations were significant except for the subjects with renal dysfunction.
Governança e prioridades da ciência brasileira
Authors: Salles-Filho Sergio
Published: February 2023

O objetivo deste artigo é apresentar e discutir a governança da ciência, o que ela engloba e quais os desafios que hoje são mais importantes em âmbitos nacional e global. O tema é abordado sob duas dimensões: governança estrita, que examina os cânones internos do funcionamento da ciência; e governança ampliada, que olha para as interfaces e interações da ciência com a sociedade. Sobretudo, discute-se o que está mudando nessas dimensões e quais os impactos e iniciativas sobre as “instituições da ciência”. Temas como ciência aberta, vieses de priorização e seleção, indicadores de qualidade, engajamento social, pesquisa orientada a missão, dentre outros, são discutidos como “espírito do tempo” e seus efeitos – de mão dupla – sobre a governança estrita e ampliada da ciência. Essa discussão é estendida para o Brasil em seus 200 anos de Independência, colocando alguns dos desafios que teremos que enfrentar.
Soldados da política: embates partidários e relações institucionais no contexto da questão militar (década de 1880)
Authors: Ribeiro Filipe Nicoletti
Published: February 2023

Empire, precisely the so-called “military question”. In the historiography, the topic is understood as a turning point that eroded such relations, and approached as fundamentally corporative, or as an ominous sign of the growing incompatibility, since the Paraguayan War, between the officers, who inculcated modernizing expectations, and the monarchy’s political elite, represented as the bulwark of an archaic social order grounded in slavery. However, exploring the primary sources – particularly official documents, newspapers, and correspondence –, I intend to argue that the military question can only be understood bearing in mind the Empire’s complex institutional framework and the party dispute dynamics.
"Meu coração, naquelas lembranças…": tentativa de catarse no relato testemunhal de Riobaldo
Authors: Oliveira Aryanna dos Santos
Published: February 2023

Este ensaio pretende analisar as memórias de Riobaldo, protagonista de Grande sertão: veredas, de Guimarães Rosa, como um relato de teor testemunhal, que se estabelece como uma “topografia da memória” (Selligmann-Silva, 2019), consequência de uma rememoração exaustiva, sofrida e (re)construída em muitas camadas, como forma de superação das marcas do trauma de suas travessias. Mesmo que diante de um testemunho ficcional, o relato extrapola os sentidos da memória individual para a coletiva, adquirindo também caráter histórico. Nos relatos da memória desse narrador problemático, cindido de experiências traumáticas, reconhece-se um labor discursivo testemunhal, que se aproxima dos verificados nas escritas de si dos testemunhos das grandes tragédias da humanidade. Partindo dos conceitos benjaminianos sobre memória e experiência, pretende-se aludir aos modos como Rosa atualiza a ideia de rememoração, perpassando a transmissão da sabedoria pela contação de Riobaldo para a elaboração de uma memória traumática do sertão, a partir de um complexo processo de revisitação de experiências frente a situações-limite, que têm, por fim, a catarse.
A primeira pessoa em prisma: uma leitura de “O unicórnio”, de Hilda Hilst
Authors: Santos Dheyne de Souza
Published: February 2023

Este trabalho analisa alguns aspectos da narrativa “O unicórnio”, de Hilda Hilst, publicada em 1970: a fragmentação formal e o deslocamento de vozes para narrar em primeira pessoa. Esses procedimentos formais são aqui associados a conflitos provenientes de uma estrutura social homogeneizante e autoritária. A noção de narrador descentrado, isto é, que está fora do centro heteronormativo, apresentada por Jaime Ginzburg (2012), contribui para analisar a construção da narração em primeira pessoa em “O unicórnio”. Na narrativa, o recurso do deslocamento dá voz a personagens fora do centro patriarcal e heteronormativo, como a lésbica, a escritora, o unicórnio, entre outros. Esse descentramento da voz narrativa é posto em diálogo com a noção de sujeito descentrado, de Stuart Hall (2006). Para esse autor, com as mudanças estruturais nas sociedades no final do século XX, o sujeito passa a assumir identidades diferentes, as quais não são unificadas ao redor de um “eu” coerente. Essa “perda do sentido de si” caracterizaria um descentramento do sujeito, cuja identidade não é fixa, essencial ou permanente. Em “O unicórnio”, as vozes que narram apresentam-se descentradas, deslocadas e fragmentadas, sob a opressão de uma perspectiva social hegemônica que responde à globalização, à cultura de massa e ao autoritarismo. Nesta leitura, são propostas relações entre a configuração formal fragmentária, o descentramento da primeira pessoa e uma estrutura social desordenada e violenta.
Por algum viés da lembrança: a memória política cifrada em Estorvo, de Chico Buarque
Authors: Alencar João Vítor Rodrigues
Published: February 2023

Através da inquietante caracterização que o narrador faz da personagem de um amigo que não vê há cinco anos, buscaremos indicar como determinados materiais relacionados à memória de nosso passado ditatorial são representados de maneira cifrada pela forma com que a voz narrativa os reelabora e/ou reprime a partir de seu presente.
O campo de concentração "modelo" de Terezín
Authors: Fernandes Luciane Bonace Lopes
Published: February 2023

Não há.
Contemporary Management Before Chronic Total Occlusion Percutaneous Coronary Interventions: Insights From the Veterans Affairs Clinical Assessment, Reporting, and Tracking Program
Authors: Swat Stanley A. , Hebbe Annika , Plomondon Mary E. , Park Ki E. , Bricker Rory S. , Waldo Stephen W. , Valle Javier A.
Published: February 2023

Background:

Guidelines recommend maximal antianginal medical therapy before attempted coronary artery chronic total occlusion (CTO) percutaneous coronary intervention (PCI). The degree to which this occurs in contemporary practice is unknown. We aimed to characterize the frequency and variability of preprocedural use of antianginal therapy and stress testing within 3 months before PCI of CTO (CTO PCI) across a nationally integrated health care system.

Methods:

We identified patients who underwent attempted CTO PCI from January 2012 to September 2018 within the Veterans Affairs Healthcare System. Patients were categorized by management before CTO PCI: presence of ≥2 antianginals, stress testing, and ≥2 antianginals and stress testing within 3 months of PCI attempt. Multivariable logistic regression and inverse propensity weighting were used for adjustment before trimming, with median odds ratios calculated for variability estimates.

Results:

Among 4250 patients undergoing attempted CTO PCI, 40% received ≥2 antianginal medications and 24% underwent preprocedural stress testing. The odds of antianginal therapy with more than one medication before CTO PCI did not change over the years of the study (odds ratio [OR], 1.0 [95% CI, 0.97–1.04]), whereas the odds of undergoing preprocedural stress testing decreased (OR, 0.97 [95% CI, 0.93–0.99]), and the odds of antianginal therapy with ≥2 antianginals and stress testing did not change (OR, 0.98 [95% CI, 0.93–1.04]). Median odds ratios (MOR) showed substantial variability in antianginal therapy across hospital sites (MOR, 1.3 [95% CI, 1.26–1.42]) and operators (MOR, 1.35 [95% CI, 1.26–1.63]). Similarly, preprocedural stress testing varied significantly by site (MOR, 1.68 [95% CI, 1.58–1.81]) and operator (MOR, 1.80 [95% CI, 1.56–2.38]).

Conclusions:

Just under half of patients received guideline-recommended management before CTO PCI, with significant site and operator variability. These findings suggest an opportunity to reduce variability in management before CTO PCI.
USP25 Ameliorates Pathological Cardiac Hypertrophy by Stabilizing SERCA2a in Cardiomyocytes
Authors: Ye Bozhi , Zhou Hao , Chen Yanghao , Luo Wu , Lin Wante , Zhao Ying , Han Jibo , Han Xue , Huang Weijian , Wu Gaojun , Wang Xu , Liang Guang
Published: February 2023

Background:

Pathological cardiac hypertrophy can lead to heart failure and is one of the leading causes of death globally. Understanding the molecular mechanism of pathological cardiac hypertrophy will contribute to the treatment of heart failure. DUBs (deubiquitinating enzymes) are essential to cardiac pathophysiology by precisely controlling protein function, localization, and degradation. This study set out to investigate the role and molecular mechanism of a DUB, USP25 (ubiquitin-specific peptidase 25), in pathological cardiac hypertrophy.

Methods:

The role of USP25 in myocardial hypertrophy was evaluated in murine cardiomyocytes in response to Ang II (angiotensin II) and transverse aortic constriction stimulation and in hypertrophic myocardium tissues of heart failure patients. Liquid chromotography with mass spectrometry/mass spectrometry analysis combined with Co-IP was used to identify SERCA2a (sarcoplasmic/endoplasmic reticulum Ca2+-ATPase 2A), an antihypertrophy protein, as an interacting protein of USP25. To clarify the molecular mechanism of USP25 in the regulation of SERCA2a, we constructed a series of mutant plasmids of USP25. In addition, we overexpressed USP25 and SERCA2a in the heart with adenoassociated virus serotype 9 vectors to validate the biological function of USP25 and SERCA2a interaction.

Results:

We revealed increased protein level of USP25 in murine cardiomyocytes subject to Ang II and transverse aortic constriction stimulation and in hypertrophic myocardium tissues of patients with heart failure. USP25 deficiency aggravated cardiac hypertrophy and cardiac dysfunction under Ang II and transverse aortic constriction treatment. Mechanistically, USP25 bound to SERCA2a directly via its USP (ubiquitin-specific protease) domain and cysteine at position 178 of USP25 exerts deubiquitination to maintain the stability of the SERCA2a protein by removing the K48 ubiquitin chain and preventing proteasomal pathway degradation, thereby maintaining calcium handling in cardiomyocytes. Moreover, restoration of USP25 expression via adenoassociated virus serotype 9 vectors in USP25
−/−
mice attenuated Ang II-induced cardiac hypertrophy and cardiac dysfunction, whereas myocardial overexpression of SERCA2a could mimic the effect of USP25.

Conclusions:

We confirmed that USP25 inhibited cardiac hypertrophy by deubiquitinating and stabilizing SERCA2a.
Homegrown Heroes: Peasant Masculinity and Nation-Building in Modern Egyptian Art
Authors: Ayad Lara
Published: February 2023

On January 18, 1938 the Fuad I Agricultural Museum in Cairo opened its palatial doors to the local public and featured four untitled portraits (1934–1937) of peasant men sporting distinctive costumes and handicrafts. The artist behind these prominent paintings was an Egyptian named Aly Kamel al-Deeb (1909–1997), whose early career combined commissions at official museums and participation in anti-establishment artist groups in Egypt. What could explain al-Deeb's transition from creating art in opposition to national museums, to painting for such institutions? This essay analyzes al-Deeb's four paintings, which I call Homegrown Heroes, and argues that they began shifting the urban Egyptian public's perceptions of the male peasant subject and his role in achieving national sovereignty. Many scholars put nationalist and avant-garde narratives of Egyptian identity in opposition. This essay reveals the patriarchal frameworks underlying representations of folk art and authenticity among nationalists and the avant-garde alike in their meditations on the peasant figure. Contextualizing Homegrown Heroes in the surrounding art and science displays, popular culture, and sociopolitical shifts of the interwar period shows that male peasant figures in Egyptian art transformed from passive symbols of cultural backwardness to heroic citizens who use folk-art practices to liberate Egypt from Western imperialism.
Degraded Objects, Harrowed Bodies: Roman Stańczak and Shock Therapy in Poland, 1990–96
Authors: Michalska Dorota Jagoda
Published: February 2023

Roman Stańczak's artistic practice can be seen as a symptomatic expression of the multi-layered processes of degradation as experienced in some Polish regions with the advent of capitalism and the country's entry into the global market at the turn of the 1990s. The neoliberal reforms in Poland brought about dramatic social consequences, leading to an exponential increase in income inequality, unemployment rate and the share of population living below the minimum subsistence level. On the rise throughout the 1990s and reaching its peak in the 2000s, the degradation suffered by some social groups and communities was both material and psychological, social and class-related. Stańczak's performances and sculptures, with their depictions of ruined, wounded and degraded bodies and objects, closely correspond to that reality, which for a long time remained outside the scope of interest of Polish neoliberal parties and the media sphere, which fully endorsed the government's policies throughout the 1990s.
Lend Me Your Eyes
Authors: Ferreira Gina
Published: February 2023

The introductory text situates the therapeutic practices of Gina Ferreira and Lula Wanderley in relation to the work of Brazilian modernist artist Lygia Clark. Ferreira is a social psychologist who uses the arts—for instance, photography and film—for the socialization and treatment of psychiatric patients. Wanderley is an artist who brings creativity into the realm of psychiatric care. Both have significantly expanded the sites and amplified the applications of Clark's Estruturação do self (Structuration of the self) therapy sessions by working in public psychiatric hospitals and clinics in Rio de Janeiro and with marginalized populations. In “Lend Me Your Eyes,” Gina Ferreira offers a poetic account of both Lygia Clark's practice and how communication became a “‘therapeutic’ possibility” for the artist. These thoughts frame Ferreira's narration of her clinical care of a client (patient) named Pedro. In “The Silence That Words Hold,” Lula Wanderley describes his artistic engagement with psychiatry and his use of Clark's therapy with clients such as Rosa. The two articles compelling attest to how Clark's Estruturação do self resonates beyond the institutionalized spaces of the art museum and the academy.
The Silence That Words Hold
Authors: Wanderley Lula
Published: February 2023

The introductory text situates the therapeutic practices of Gina Ferreira and Lula Wanderley in relation to the work of Brazilian modernist artist Lygia Clark. Ferreira is a social psychologist who uses the arts—for instance, photography and film—for the socialization and treatment of psychiatric patients. Wanderley is an artist who brings creativity into the realm of psychiatric care. Both have significantly expanded the sites and amplified the applications of Clark's Estruturação do self (Structuration of the self) therapy sessions by working in public psychiatric hospitals and clinics in Rio de Janeiro and with marginalized populations. In “Lend Me Your Eyes,” Gina Ferreira offers a poetic account of both Lygia Clark's practice and how communication became a “‘therapeutic’ possibility” for the artist. These thoughts frame Ferreira's narration of her clinical care of a client (patient) named Pedro. In “The Silence That Words Hold,” Lula Wanderley describes his artistic engagement with psychiatry and his use of Clark's therapy with clients such as Rosa. The two articles compelling attest to how Clark's Estruturação do self resonates beyond the institutionalized spaces of the art museum and the academy.
Eugenia (Myrtaceae) from Mexico: checklist, distribution, and conservation assessments
Authors: GALA VICTOR C. UC , VALDEMARIN KARINNE SAMPAIO , LUCAS EVE , NEGRÃO RAQUEL , MAZINE FIORELLA F.
Published: February 2023

Myrtaceae is represented in Mexico by 10 genera and ca. 109 species mainly occurring in warmer climatic zones. Eugenia is one of the most diverse genera in Myrtaceae, with about 1,150 species, distributed from Mexico, Cuba and the Antilles to Uruguay and Argentina, with fewer representatives in Africa and Southeast Asia. This study presents a checklist of the 87 species of Eugenia that occur in Mexico as well as provides assessments of environmental threat for each species. The checklist was prepared in stages, gathering data from international databases, consulting relevant bibliography (mainly Mexican Floras), personal visits to key herbarium collections (MEXU, CICY and K), and analysis of specimen images available online. Extinction risk assessments follow the categories and criteria of the IUCN Red List of Threatened species version 3.1. calculating the extent of occurrence (EOO) and area of occupancy (AOO) parameters using the GeoCat software (Geospatial Conservation Assessment Tool). Extinction risks are provided for eighty-seven species of Eugenia, including notes on species distributions. Mexican states with the highest number of species of the genus are Chiapas and Veracruz, with 48 and 31 species, respectively. Forty-six species are endemic to Mexico, which represents 53% of the total of species occurring in the country. Regarding extinction risk, from a total of 87 species, 33 species (38%) are assessed with a threatened category, with 7 Critically Endangered (CR), 14 Endangered (EN), and 12 Vulnerable (VU); 54 species are not threatened, 42 of these rated as Least Concern (LC) and 12 as Near Threatened (NT). This study reveals the degree of extinction risk that exists to native or endemic Mexican Eugenia species, and highlights the urgent need to take action to protect, conserve and monitor their populations in the wild.
Lectotypification of 4 names of Viburnum (Adoxaceae)
Authors: ZHAO LIAO-CHENG , TANG MING
Published: February 2023

Examination of the protologues of Viburnum henryi, V. brachybotryum var. tengyuehense, V. theiferum and V. ternatum revealed that at least two gatherings were mentioned as types for every one of them, making it necessary to designate a lectotype for each of the 4 names.
Typification and threat assessment of Jasminum parkeri (Oleaceae), a point endemic and critically endangered species of Indian Western Himalaya
Authors: SRIVASTAVA AMBER , WAGH VIJAY V. , SRIVASTAVA S. K.
Published: February 2023

While assessing the threat status and conservational approach of Jasminum parkeri Dunn, an endemic and threatened taxon in Indian Western Himalaya, it has been noticed that the name of this species has not been typified so far. This article deals with the lectotypification of Jasminum parkeri and conservation efforts of this highly habitat specific species.
Bupleurum iranicum (Apiaceae), a new species from Talesh Mountains, northwestern Iran
Authors: BIDARLORD MAHMOUD , KLJUYKOV EUGENE , LYSKOV DMITRY
Published: February 2023

A new species, Bupleurum iranicum (Apiaceae), is described from Ardabil Province, northwestern Iran. The new species is similar to B. anatolicum and B. brachiatum in the narrow, linear cauline leaves, herbaceous bracts similar to bracteoles, bracteoles shorter than the flowers, fruit surface, and petals smooth, and number of umbel rays 2–3. At the same time, the new species differs from the above-mentioned taxa in features of the stem features (non-branched or slightly branched vs. diffusely or dichotomously branched), umbel rays (subequal vs. unequal), length and number of bracts (equal 1–2 vs. subequal 2–5), and shape (elliptic to ovate vs. lanceolate). A detailed description and comparisons with other similar taxa, color images, distribution and habitat, and a taxonomic key to the Bupleurum species from Iran are provided. The new species should be listed as Critically Endangered, its protection is therefore recommended.
Catalog of the genus Cacia Newman (Coleoptera, Cerambycidae, Lamiinae) in the Philippines with description of two new species
Authors: MEDINA MILTON NORMAN , VITALI FRANCESCO , BARSEVSKIS ARVIDS
Published: February 2023

A catalog of the genus Cacia Newman, 1842 is provided for the Philippines accounting to 47 species and 2 subspecies is provided. Cacia (s. str.) cabrasae sp. nov. and Cacia (Ipocregyes) manobo sp. nov. are proposed for the Philippine fauna.
Family Nogodinidae (Hemiptera: Fulgoroidea) from the Canary Islands, with the description of a new species of the genus Morsina Melichar, 1902
Authors: GNEZDILOV VLADIMIR M. , LÓPEZ HERIBERTO , SUÁREZ DANIEL
Published: February 2023

Planthopper family Nogodinidae is recorded for the first time from the Canary Islands after a new species, Morsina gomerae sp. nov., described from the dry landscapes of La Gomera island. Mikewilsonia Holzinger, 2019 is placed in synonymy under Morsina Melichar, 1902. Mikewilsonia kunzi Holzinger, 2019 is transferred to Morsina with a new combination proposed—Morsina kunzi (Holzinger, 2019), comb. nov.