bluuebunny/crossref_metadata_2025 huggingface dataset:
Strategi Komunikasi Lingkungan Pandawara Group dalam Menyebarkan Kesadaran Ekologis di Kota Bandung
Authors: Nasas Fathiya Sabila , Pradipta Dirgantara
Published: July 2024

Masalah sampah di Kota Bandung mendesak perhatian serius dengan pertumbuhan populasi dan aktivitas ekonomi yang terus meningkat. Pandawara Group, sebuah inisiatif pemuda, mengambil langkah konkret dengan memimpin gerakan peduli lingkungan melalui program "Clean Up" dan "Ajaraksa". Penelitian  ini menggunakan  menggunakan teori strategi komunikasi lingkungan yang dikembangkan oleh Richard R. Jurin, Donny Roush, dan Jeff Danter. Teori ini memuat 11 tahapan strategi, mulai dari pernyataan masalah, tujuan, analisis audiens, objektif, hingga pemilihan media dan desain komunikasi. Dengan  fokus pada kesadaran ekologis, diintegrasikan dengan teori aspek kesadaran ekologis dari Muhaimin, yaitu aspek pengetahuan, sikap, keterampilan, dan partisipasi masyarakat. Subjek penelitian ini adalah strategi komunikasi yang digunakan oleh Pandawara Group untuk menyebarkan kesadaran ekologis di Kota Bandung. Penelitian ini menggunakan metode kualitatif studi kasus degan objek pada program "Clean Up" dan "Ajaraksa" yang dilakukan oleh Pandawara Group dengan tujuan untuk menyebarkan kesadaran ekologis di Kota Bandung. Hasil penelitian menunjukkan bahwa Pandawara Group telah melakukan strategi komunikasi lingkungan melalui 11 tahapan yaitu pernyataan masalah, tujuan, analisis audiens, objektif, pengembangan pesan, pemilihan media dan desain, jangka waktu, evaluasi awal, evaluasi formatif, evaluasi sumatif, dan anggaran proyek. Namun begitu di setiap tahapannya, tidak selalu mencerminkan aspek kesadaran ekologis, namun setidaknya terdapat satu atau dua aspek yang mencerminkan di setiap strategi komunikasi lingkungan. Dengan memanfaatkan platform digital seperti TikTok dan Instagram, Pandawara Group telah menyebarkan pesan lingkungan kepada audiensnya, terutama generasi muda yang aktif berinteraksi di media sosial.
Mengeksplorasi Peran Komunikasi dalam Meningkatkan Wisata Gastronomi di Madura
Authors: Suryandari Nikmah , Farida Nurul Rahmawati  , Ferry Adhi Dharma
Published: July 2024

This article examines the increasing popularity of gastronomic tourism, which emphasizes the opportunity to taste local cuisine and get to know its gastronomic traditions. What is the value of efficient communication in enhancing the gastronomic tourism experience in terms of language, culture and cuisine. The growing importance of social media for connecting travelers with local communities is explained in this article. The purpose of this paper is to find out how communication can improve the culinary tourism experience in Madura. Tourists who have the opportunity to interact with the community will better appreciate the local way of life and culinary delights. The research design used is descriptive qualitative. The informants in this research are tourists who visit Madura and managers of culinary and gastronomic tourist attractions in this region. The results show that tourists who visit Madura obtain information about tourist destinations from the media and have positive experiences while traveling. Managers of culinary and gastronomic tourist attractions have not utilized communication media optimally due to technical obstacles. A sustainable and responsible gastronomic tourism policy is a positive recommendation for the development of gastronomic tourism in this region.
Representasi Budaya Korupsi Dalam Film Ice Cold: Murder, Coffee and Jessica Wongso
Authors: Rahmansyah Brian Yudhistira , Setyo Wibowo Novin Farid
Published: July 2024

ABSTRACT Corruption has become a common problem in Indonesia. Corruption in Indonesia has existed since the colonial era and continues, starting from even the smallest level. Even in 2022, the Indonesian NGO Wach Corruption found 579 cases, 1,396 suspects, and state losses of IDR 42,747 trillion, bribes of IDR 693 billion, illegal levies of IDR 11.6 billion, and money laundering of IDR 955 billion. Therefore, this research aims to find out how the culture of corruption is represented in the film Ice Cold: Murder, Coffee and Jessica Wongso. Researchers use a qualitative approach and use semiotic methods, especially John Fiske's codes. The subject used in this research is the film Ice Cold: Murder, Coffee and Jessica Wongso, while the object of this research is the representation of corruption culture in the film Ice Cold: Murder, Coffee and Jessica Wongso. Through the film Ice Cold: Murder, Coffee and Jessica Wongso, Reza Indragiri and Yudi Wibowo succeeded in showing that in Indonesia today the culture of corruption is still very common, such as the bribery case told by Reza Indragiri and Yudi Wibowo's opinion that in Indonesia today everything is about money, which is even Justice can also be bought even by bribing the person concerned.
PENGARUH VARIASI KUAT ARUS SMAW TERHADAP SIFAT MEKANIK BAJA AISI 1045
Authors: Muliastri Destri , Iryani Lenny , Setiawan Dibyo , Ramadhan Kukuh , Okviyanto Toni
Published: July 2024

This study discusses the effect of variations in the parameters of the welding process on the tensile strength and Vickers hardness tests. In general, it is widely known that in the fabrication process, welding is a very important process that is used to join two or more materials. The welding process is carried out with variations in the strength of the welding current, namely 75, 85, and 95 A. The experimental method used in this research is AISI 1045 steel material with a thickness of 6.0 mm. The results of the tensile strength test have the highest value at a current strength of 75 A which is equal to 756.642 MPa. The lowest tensile strength test results were obtained with a tensile strength of 687.608 MPa at a current strength of 95 A. specimens with variations in current strength of 95 A have the highest value in the Vickers hardness test, with a hardness value of 281.25 HV. From the research conducted it is known that as the welding current increases there is a decrease in the value of the tensile strength. The hardness value in the heat affected zone (HAZ) area of all test specimens has the highest value, while the hardness value of weld metal (WM) and base metal (BM) has almost the same hardness value.
THE EFFICIENCY AND COEFFICIENT OF SPORTS BALLS RESTITUTION USING AN ACOUSTIC APPLICATION
Authors: Pacala Frank Angelo Abayog , Pili Unofre
Published: July 2024

Studying the efficiency of a sports ball and its coefficient of restitution is important for performance optimization, fairness, and consistency of play. This research paper is dedicated to studying the coefficient of restitution and bounce efficiency in sports ball. Ping Pong ball and tennis balls were used to show the relationship between the bounce height and drop height. This paper used standard laboratory equipment like meter ruler, retort stand, clamp and with the utilization of the acoustic program of the smartphone using PhyPhox. The result showed that the application was able to accurately measure the bounce height in relation to the drop height. This was showed in the straight-line graph plotted. There was a constant ball efficiency coefficient of restitution and have very small percent error from the standard. This experiment can boost the interest and confidence of students in the classroom. Being able to accurately measure the performance of different balls can help students understand the science and engineering principles behind how they work. This knowledge can benefit students by allowing them to make more informed decisions when purchasing sports equipment, as well as give them an opportunity to modify their playing methods and strategies.
Periprosthetic Patellar Fracture Fixation With Locking Star-plate: a Case Series
Authors: Hrudka Bryce T. , Hall Jacob T. , Neilson John C.
Published: July 2024

Introduction: This study aims to evaluate the effectiveness of a fixed-angle locking star-plate for the fixation of periprosthetic patellar fractures (PPPFs) in individuals with partial or total knee arthroplasty (TKA). The objectives focus on patient outcomes, complication rates, and functional recovery.
Materials and Methods: A retrospective case series design was utilized, encompassing a chart review at a single-center Level 1 Trauma Center. The population included patients with PPPFs who underwent open reduction and internal fixation (ORIF) with a fixed-angle locking star-plate from September 2021 to January 2023. Clinical examinations and radiographs were used to assess outcomes and complications.
Results: Three patients were treated for PPPFs. A 77-year-old male (Patient 1) resumed normal activities and reported complete pain relief at four months post-ORIF. A 51-year-old female (Patient 2) demonstrated enhanced pain control and increased knee flexion, although she presented a non-healing surgical wound. A 70-year-old female (Patient 3) with severe PPPF and osteoporosis experienced an extensor mechanism disruption and infection, leading to hardware removal and permanent knee extension loss. The follow-up period ranged from 2.5 weeks to four months postoperatively. Conclusions: Fixed-angle locking star-plate fixation for PPPFs generally showed favorable results. However, the treatment of a patient with severe osteoporosis and extensor mechanism impairment resulted in a suboptimal outcome. These findings underscore the importance of tailored approaches to PPPF management and highlight the need for further research to compare treatment methods.
How different are the alternative Economic Policy Uncertainty indices? The case of European countries.
Authors: Baxa Jaromír , Šestořád Tomáš
Published: July 2024

Several alternative news-based Economic Policy Uncertainty indices have been developed for Spain and a few other European countries. These alternative indices differ in the selection of keywords, newspaper coverage, and a scaling factor that is used to calculate the EPU index from the raw news data. Using the generalized forecast error variance decompositions of the time-varying parameter VAR model and the analysis of dynamic connectedness, we show that the restriction to include only domestic news affects estimated spillovers substantially, leading to different qualitative and quantitative assessments of uncertainty spillovers in Europe. Therefore, not all EPU indices are the same.
JEL Classification: C32, F42, F45
Cancer- and non-cancer risk assessment of chlorination by-products in indoor swimming pools in Shenzhen, China
Authors: Liu Qingcheng , Shao Peng , Sun Jian , Shi Rongjie , Li Langwen , Zeng Wei , Chen Fengping , Li Wenjie , Li Li
Published: July 2024

Background
Trihalomethanes (THMs) generated in chlorinated pools have raised great concerns for potential genotoxic, carcinogenic and mutagenic features. The present study aimed to assess multi-exposure cancer and non-cancer risk of THMs in indoor swimming pools in Shenzhen, China.
Methods
Six representative indoor swimming pools located in west, central and east of Shenzhen were selected, with waters at 30 cm below and air at 1.2 m above water surface sampled. Headspace gas chromatography-electron capture detector (HSGC-ECD) was used to measure water THMs, and thermal desorption gas chromatography (TD-GC) was adopted to measure air THMs. Swimmer Exposure Assessment Model (SWIMODEL) recommended by USEPA was performed to assess the lifetime cancer and non-cancer risk of THMs.
Results
The median THMs in pool waters was 48.69 µg/L (IQR: 36.81–65.72), and 45.69 µg/m3 (IQR: 24.61–112.50) for ambient air, both with chloroform (TCM) and bromodichloromethane (BDCM) as predominant components. The daily THMs intake was 1.40E-02 µg/kg.d (range: 6.72E-03–3.96E-02), with estimated lifetime cancer risk 9.39E-07 (range: 3.59E-07–3.05E-06) and non-cancer risk 1.26E-03 (range: 6.21E-04–3.58E-03). Inhalation was major exposure route, accounting for 70.5% of total THMs intaking. Female swimmers had significantly higher cancer risk (P = 0.028) and non-cancer risk (P = 0.028) than male swimmers.
Conclusions
The estimated lifetime cancer risk of THMs in indoor swimming pools in Shenzhen was below the USEPA‘s regulatory threshold of 1.0E-06, and non-cancer risk was less than the unacceptable level of 1.0. The lifetime cancer- and non-cancer risk was acceptable for THMs in indoor swimming pools in Shenzhen, China.
How Much Data Do You Need? An Analysis of Pelvic Multi-Organ Segmentation in a Limited Data Context
Authors: Lunardo Febrio , Baker Laura , Tan Alex , Baines John , Squire Timothy , Dowling Jason A , Azghadi Mostafa Rahimi , Gillman Ashley G
Published: July 2024

Introduction:
Deep learning models benefit from large and varied, but costly, datasets. This study investigates the dataset size trade-off in the context of pelvic multi-organ MR segmentation; specifically assessing the performance of a well-known segmentation model, nnU-Net, in a limited domain and limited dataset setting.
Materials/methods:
12 participants undergoing treatment on an Elekta Unity were recruited, acquiring 58 MR images, with 4 participants (12 images) withheld for testing. Prostate, seminal vesicles (SV), bladder and rectum were contoured in each image by a radiation oncologist. Six more models were trained on progressively smaller subsets of the training dataset, simulating a restricted dataset setting. To observe the efficacy of data augmentation, another set of identical models were trained without augmentation. The performance of the networks was evaluated via the Dice Similarity Coefficient, mean surface distance and 95% Hausdorff distance metrics.
Results:
When trained with entire training dataset (46 images), the model achieved a mean Dice coefficient of 0.903 (Prostate), 0.851 (SV), 0.884 (Rectum) and 0.967 (Bladder). Segmentation performance remained stable when the number of training sets was >12 images from 4 participants, but rapidly dropped in smaller data subsets. Data augmentation was found to be influential across all dataset sizes, but especially in very small datasets.
Summary:
This study demonstrated nnU-Net's ability in performing pelvic multi-organ segmentation in a limited domain and limited data context. We conclude that while our model may not generalise well to scanner or protocol changes, the protocol’s low data requirement can be advantageous for in-house cases with a consistently narrow domain. For example, it could assist in treatment planning by initiating the contouring process instead of manually starting from the beginning.
Study on Electromagnetic Characteristics of Control Cores in Shearer Cables
Authors: Zhao Lijuan , Jiang Beichen , Bu Jiazheng
Published: July 2024

This study investigates crosstalk in shearer cables used in underground environments, affecting their electromagnetic stability. Unique underground conditions necessitate specific research for these cables, unlike those for vehicle, aircraft, and railway cables. This paper uses a finite-difference time-domain (FDTD) modeling method with EMA3D to accurately simulate these conditions and explores integrating steel wire ropes within control cores to enhance electromagnetic stability.Simulation experiments show that embedding steel wire ropes significantly improves electromagnetic stability. Optimal shielding occurs when the steel wire rope diameter matches the twisted diameter of other cable cores, enhancing stability by over 20% compared to cables without steel wire ropes. Under bent conditions, larger steel wire rope diameters improve effectiveness by more than 10%. The study also examines the impact of the diameter difference between steel wire ropes and twisted cable cores, finding that a larger difference has a more significant impact.These findings suggest that the relationship between the diameters of steel wire ropes and cable cores should be carefully considered in cable design to optimize electromagnetic stability. This study provides an effective solution to crosstalk in shearer cables and offers insights for improving electromagnetic stability in various applications.
Current status of proton pump inhibitor usage in patients with acute coronary syndrome and nonvalvular atrial fibrillation: A cross-sectional study
Authors: Bai Ying , Wang Jianqi , Li Guangyao , Zhou Zhen
Published: July 2024

Objective
The real-world status of proton pump inhibitor (PPI) administration in patients with acute coronary syndrome (ACS) and atrial fibrillation (AF) is largely unknown. This study aimed to analyze the prescription patterns of PPI in Chinese patients with ACS and nonvalvular AF.
Methods
This single-center, retrospective, cross-sectional study included patients with ACS and AF who were hospitalized in the Department of Cardiovascular Center at Beijing Tongren Hospital from January 2010 to December 2018. All patients were categorized into two groups (PPI and non-PPI groups) based on PPI usage, and factors influencing PPI use were analyzed. The appropriateness of PPIs prescriptions was evaluated according to clinical guidelines.
Results
This study included 531 patients with ACS and AF. Patients receiving PPIs were more likely to have non-ST-segment elevation myocardial infarction (NSTEMI) (27.6% vs. 19.5%, p = 0.028), STEMI (33.9% vs. 16.2%, p < 0.001), paroxysmal AF (65.0% vs. 50.5%, p < 0.001), gastrointestinal disorders (59.4% vs. 7.9%, p < 0.001), and lower systolic blood pressure (125mmHg vs. 130mmHg, p = 0.008) as well as underwent percutaneous coronary intervention or coronary artery bypass graft or fibrinolytic (44.1% vs. 35.4%, p = 0.040) and catheter ablation (9.1% vs. 1.4%, p < 0.001), they were frequently treated with oral anticoagulants (30.7% vs. 19.9%, p = 0.003). 249 (46.9%) patients did not adhere to guideline recommendations at discharge.
Conclusions
The study revealed that 47.8% of patients with AF and ACS were prescribed PPI, while 46.9% of patients did not adhere to guideline. It is likely that interventions will be necessary to enhance adherence to guidelines to reduce the risk of GIB.
Mating system analysis of Spanish argan [Argania spinosa (L.) Skeels] accessions in-situ and ex-situ conserved by using SSR markers
Authors: Martínez-Gómez Pedro , Patiño-García María , Devin Sama Rahimi , López-Alcolea Jesus , Mahdavi Sayyed Mohammad Ehsan , Bastida Felipe , Rubio Manuel
Published: July 2024

The argan tree [Argania spinosa (L.) Skeels] is a multipurpose species endemic of Morocco. It has been mainly characterized as a self-incompatible (SI) species. Argan trees are also found in Murcia, a region located in Southeaster Spain, where they are currently yielding viable fruits and seeds in an isolated environment. This study investigated the self-compatibility (SC) of these Spanish argan accessions. This was done through in-situ research and characterization of isolated argan trees in open pollination settings. Addi-tionally, the seedlings from these trees were characterized using (Simple Sequence Repeat) SSR markers. In addition, the ex-situ study of the collection of Spanish argan accessions from the CEBAS-CSIC (Centro de Edafología y Biología Aplicada del Segura-Consejo Superior de Investigaciones Científicas) in Murcia, have also be characterized in open polli-nation conditions and by bagging argan accessions to evaluate fruit set in absence of pollinator also analysing the obtained seedlings by SSRs. As expected, in the analysis of in-situ conserved argan accessions, the isolated trees showed a suitable flowering intensity during the two years evaluated. However, while the Spanish argan accessions isolated from ‘Cartagena’ and ‘Mazarrón’ showed fruits, the accessions from ‘Molina de Segura’ and ‘Ojos’ showed a null fruit set in both years. In the case of bagging of these ex-situ con-served accessions, results showed that in the absence of natural pollinators of argan (especially flies), a certain level of fruiting is observed in bagged branches in some specimens. First results showed then that self-fertilization is possible in some argan accessions and that fruits are obtained without pollen from other accessions. If self-compatibility accessions are confirmed in Spain or Morocco, they are very useful for basic research in breeding programmes.
Two recurrent pathogenic/likely pathogenic variants in PALB2 account for almost half of PALB2 positive families in Slovenia
Authors: Mesarič Vita Andreja , Blatnik Ana , Starič Kristina Drusany , Strojnik Ksenija , Stegel Vida , Hotujec Simona , Šetrajčič Vita Dragoš , Škerl Petra , Novaković Srdjan , Krajc Mateja
Published: July 2024

Introduction: The prevalence and spectrum of PALB2 pathogenic/likely pathogenic variants (PV/LPVs) may vary across different regions, and these have not yet been analysed and reported in Slovenian HBOC families. Methods: We performed a retrospective analysis of all 5099 consecutively tested individuals from 4610 families who fulfilled national criteria for HBOC-panel testing from January 2015 to January 2022. After genetic counselling, genetic testing with next generation sequencing was performed for all probands and cascade testing was offered to their blood relatives. Results: Among all probands tested 0.9% (40/4610) were PALB2 PV/LPV carriers. 14 different PALB2 PV/LPVs were detected, one of them was novel. Five PV/LPVs were found to be recurrent in Slovenian population with two most frequent being c.509_510del and c.1451T > A. Altogether, 61 individuals from 41 PALB2 positive families were identified, 43 being cancer patients. 27.9% PALB2-positive cancer patients were diagnosed with more than one malignant tumour. We identified three double heterozygote carriers with additional PV/LPVs in ATM, CHEK2 and BRCA1. Discussion: This report provides the first comprehensive description of molecular and clinical characteristics of PALB2 carriers in Slovenia. The frequency of PALB2 pathogenic variants in the Slovenian HBOC accounts for 0.9% of all individuals tested for PVs in HBOC-related genes. Our study adds a novel recurrent mutation, which is unique to the Slovenian context and one PV/LPVs, which had not been reported in the literature so far. The results of our study add information on genotype and phenotype in PALB2-positive patients and may be used for population specific assessment. Ethics approval: The present study was approved by the National Ethics Committee and the Institutional Ethics Committee of the Institute of Oncology Ljubljana (0120–591/2020/3 on the 20th of January 2021).
Hybrid analysis for Tolcv (Tomato Leaf Curl Virus) and Root Knot Nematode resistance in tomato (Solanum lycopersicum L.) And molecular validation of Ty-3 and Mi-1 gene
Authors: R Shanmugabhavatharani , T Saraswathi , M Kavitha , M Manivannan , N Seenivasan , S Harish
Published: July 2024

Tomato (Solanum lycopersicum L.) is a vital vegetable crop cultivated due to their abundant supply of nutrients, and their recent popularity is mainly accredited to the antioxidant and anti-cancer properties of lycopene. Low productivity in India is due to incidence of both tomato leaf curl virus (ToLCV) and root knot nematode (RKN), resulting in 25–100% yield loss. The aim of this study was to develop and screen tomato hybrids for ToLCV and RKN resistance and validate the presence of the Ty-3 and Mi-1 gene. The study involved evaluating 12 parents, 8 hybrids, and 7 double-cross hybrids carrying genes, which underwent screening at both phenotypic and genotypic levels. An assorted array of Sequence Characterized Amplified Region (SCAR) markers, including P6-25, FLUW-25F, SCAR-1, Mi-23, PMi, and PM3, was utilized to assess the resistance genes linked with ToLCV and RKN, focusing specifically Ty-3 and Mi-1. These markers demonstrated high reliability in distinguishing susceptible and resistant lines, facilitating the efficient identification of homozygous or heterozygous alleles. The screening for ToLCV and RKN resulted in the identification of three resistant parents (CBESL159, CBESL162, CBESL169), two hybrids (H5-CBESL133×CBESL169, H7-CBESL146×CBESL162), and two double hybrids (H5xH7 and H4xH5). These promising parents hold potential as parental materials for developing lines or hybrids with genes providing strong and enduring resistance against ToLCV, RKN and yield improvement. The double hybrids can be used for the development of breeding lines.
Clinical Characteristics and Patterns of Valve Lesions in Rheumatic Heart Disease Among Children at Hiwot Fana Comprehensive Specialized Hospital: A Comparative Study of Newly Diagnosed and Known Cases.
Authors: Libe Temesgen Teferi , Kelil Yunus Edris , Tegene Samrawit Abebaw , Abdi Faisal , Mesfin Kibrom Hailemariam
Published: July 2024

Background: Rheumatic heart disease remains a significant health burden in resource-limited settings. This study investigates the clinical characteristics and valve lesion patterns of RHD in children from Eastern Ethiopia, comparing newly diagnosed and known RHD patients.
Objective: This study aims to characterize the clinical features and valve lesion patterns in children with Rheumatic heart disease and provide a comparative analysis between newly diagnosed and known cases.
Methods: A hospital-based cross-sectional study was conducted at Hiwot Fana Comprehensive Specialized Hospital from January 1 to December 31, 2021. A total of 39 children with RHD were included, with data collected from medical records, clinical assessments, and echocardiographic evaluations. Descriptive statistics and chi-square tests were used for analysis.
Results: Among the 39 children studied, 25 were newly diagnosed and 14 were known RHD cases. The majority were female (71.8%). The median age was 10 years. Shortness of breath (53.9%) and cough (38.5%) were the most common presenting complaints. Only 14.3% of known RHD patients were adherent to secondary prophylaxis. Severe acute malnutrition and severe anemia were the most common comorbidities. Class IV heart failure was present in 89.7% of the patients. Echocardiographic findings revealed that all patients had mitral valve involvement, with mitral regurgitation (94.9%) being the most frequent.
Conclusion: The study highlights significant clinical characteristics and valve lesion patterns among children with Rheumatic heart disease at Hiwot Fana Comprehensive Specialized Hospital, emphasizing the need for early diagnosis, improved adherence to prophylaxis, and targeted interventions to manage comorbidities and advanced heart failure.
Neuromarketing as a Mechanism of Communication with the Consumer: The Case for Small Business
Authors: Chygryn Olena , Shevchenko Kateryna , Tuliakov Oleh
Published: July 2024

Neuromarketing is a modern tool for researching consumer reactions to advertising stimuli and identifying relevant consumer behaviour patterns. Conducting neuromarketing research using eye tracking technology allows us to obtain objective data on consumer perceptions of advertising, websites, product packaging, etc. This article is devoted to studying the structural and content environment of the marketing category and neuromarketing research on advertised materials via the eye-tracking method. The analysis of publishing activity on the topic of neuromarketing carried out with the help of Scopus tools and the VOSviewer toolkit showed a trend of increasing interest from the scientific community in the use of neurotechniques and technologies in the study of consumer behaviour since 2004. The results of the analysis of the structural and content environment have shown the growing interest of scientists in the detailed study of consumer reactions to a product, brand, site, and advertisement, with further conclusions regarding their preferences and priorities. The work revealed that in the field of neuromarketing, there are methods that can be conditionally divided into those that register activity in the brain (neurological) and those that register activity outside the brain (biometric). The characteristics of these methods make it possible to choose the most appropriate method of eye tracking for evaluating consumers’ reactions to advertising posters. Pupil Labs Invisible mobile eyetracker was used as the main tool for neuromarketing research. According to the results of the two stages of the experiment, heatmaps were obtained, which are described by the key metrics of the study: fixations and points of view, heatmaps, areas of interest, and time spent. With the help of research, the most profitable designs of advertising posters for consumers were determined. The influence of different colors and their combinations on the brain activity of potential consumers was analysed. As a result, a conclusion was made regarding the optimal placement of such key elements on the poster as the logo, and the price, the colour range of the presented materials and the fonts that were used were determined. The application of the obtained results of marketing research made it possible to obtain information about how consumers perceive visual stimuli, which, in the future, will be the basis for perfecting marketing communication strategies with the target audience of consumers.
Diagnosis of acute leukemia in children: the impact of remote residence on the time to make a diagnosis
Authors: Rykov M. Yu. , Dolgopolov I. S.
Published: July 2024

Background. Acute leukemia (AL) is the most common childhood cancer with an incidence rate of about 55–62 cases per 1 million children under 18 years of age. Acute leukemia is difficult to diagnose due to nonspecific symptoms, which are often hidden under the “masks” of other diseases. This problem is especially relevant for regions with a population of up to 100,000 people, where AL in children is diagnosed once every 2–5 years causing too low cancer alertness among pediatricians. Aim: to assess the delay in diagnosis depending on the areas of residence in the Tver region and area remoteness from the Tver Regional Clinical Children’s Hospital (RCC H). Material and Methods. The analysis included 35 patients hospitalized in the Department of Oncology and Hematology of the RCC H for the period from 2018 to 2023. The diagnoses were: ALL, C91.0 – 30 (86 %), AML , C92 – 3 (9 %), and AL of unspecified cell type (ALUCL ), C95.0 – 2 (5 %) patients. The mean age was 61 months. Thrombocytopenia and anemia at the time of diagnosis were found in 76 % and 78 %, respectively. Leukocytosis >20×109/L was observed in 58 %, leukopenia <3.5×109/L in 15 % of patients. In 97 % of cases, blasts (2 % to 95 %) were detected in peripheral blood. In the city of Tver (group 1) and the Tver region (group 2), 16 (46 %) and 19 (54 %) patients were identified, respectively. The mean age of patients in group 1 was 28.6 months and the mean age in group 2 was 72.3 months (p=0.1). Results. In group 1 and 2, ALL was diagnosed in 14 (88 %) and 16 (84 %), AML in 1 (6 %) and 2 (11 %) and ALUCL in 1 (6 %) and 1 (5 %) cases, p=0.6, 0.7 and 0.95, respectively. Delay in diagnosis in the general group (n=35) was observed <2 weeks in 21 (60 %) cases, 2–4 weeks – in 7 (20 %), ≥4–≤8 weeks – in 4 (11 %) and >8 weeks – in 3 (9 %) cases. Delayed diagnosis among patients living in the city of Tver and Tver region was observed <2 weeks in 7 (44 %) vs 13 (68 %) cases, 2–4 weeks – in 6 (38 %) vs 3 (17 %), ≥4–≤8 weeks – in 1 (6 %) vs 1 (5 %) and >8 weeks – in 2 (12 %) vs 2 (10 %) cases, respectively (p=0.37). There was no significant impact of the distance of the residence place from the level 3 children’s hospital providing specialized care (RCC H) on the time of diagnosis. With the removal of <50 km the diagnosis delay <2 weeks, 2–4 weeks, ≥4–≤8 weeks, >8 weeks was observed in 36, 36, 21 and 7 %, respectively. With the removal of ≥50–≤100 km, the diagnosis was made in the period of 2–4 weeks in 100 % of cases. With the removal of >100 km the diagnosis delay <2 weeks, 2–4 weeks, ≥4–≤8 weeks, >8 weeks was observed in 30, 30, 20 and 20 %, respectively (p=0.78). Conclusion. The distance from the third-level hospital did not affect the period of diagnosis of AL in children, which is achieved by holding daily on-line conferences with country hospitals and out-patient departments followed by the rapid hospitalization of children with suspected oncohematological disorders in the specialized department.
Factors of cancer diagnosed family and medical system for delay in diagnosis and treatment of esophageal cancer
Authors: Khan I. Majeed , Hussain M. , Latif A. , Sarwar A.
Published: July 2024

Introduction. The esophagus cancer patients needs early diagnosis to achieve better prognosis. The delay barriers increase progression of diseases to higher stages. The aim of work was to identify and explore the barriers in diagnosis of esophagus cancer and chart the time duration in this process. Material and Methods. The study was conducted in Jinnah Hospital Lahore (JHL), a teaching care hospital of Allama Iqbal Medical College, during a period of one year from July 2019 to July 2020. There were 49.42 % female and 50.57 % male patients. Results. Mean age found to be 56 years. Mean Total delay (TD ) time was 206 days and median Total delay (TD ) time in days were 197 days with 25th and 75th (157, 246) percentiles respectively. Longest delays were found in 51–60 age group and age related (r=0.94) significantly to delays (p=0.0004). Initial symptom of weight loss shows maximum delay and symptoms are highly correlated (r=0.94) with delay (p=0.004). The low income group presents maximum delay. Mean patient delay (PD ) time in days were 142 days with 135 Median and (88, 195) 25th and 75th percentile respectively. Mean, Median, 25th and 75th percentiles for Physician delays (PhyD) times were (20, 18, 16, 23) respectively. Treatment delay (TD ) time (Mean, Median) in days were (18, 18.52) with 25th and 75th (14, 22) percentiles. The education significantly reduces the delays with correlation (r=0.91) and significance (p=0.02). Mean system delay (SD ) time were 25 days and median were 24 days with 25th and 75th (20, 31) percentiles. Conclusion. Illiteracy, financial problems, and unavailability of information related to the cancer and health care system, very limited number of health facilities remains the main causes of these delays.
Surgical treatment of right colon cancer
Authors: Nevolskikh A. A. , Avdeenko V. A. , Reznik I. P. , Pochuev T. P. , Zibirov R. F. , Ivanov S. A. , Kaprin A. D.
Published: July 2024

The study aimed to perform a systematic review of the literature on surgical treatment for right colon cancer (RCC) with complete mesocolic excision (CME) and D2/D3 lymph node dissection (LND). Material and Methods. A literature review was performed for studies published between 2013 and 2023 by the online resources from the official Web sites of the societies/panels and PubMed database. Sources included guidelines, meta-analyses, randomized and nonrandomized clinical studies, guidelines by European Society of Medical Oncology, the Japanese Society for Cancer of the Colon and Rectum, and the National Comprehensive Cancer Network, Russian clinical guidelines. Results. CME significantly improved both immediate and long-term treatment results, which was confirmed by numerous meta-analyses. The extent of LND remains one of the most controversial issues in RCC. For many Asian surgeons, D3 LND is the standard procedure for the treatment of RCC, whereas the European approach is more conservative and apical lymph node dissection is not mandatory. There are also large differences in understanding the extent of D3 LND in RCC. Most surgeons understand this term as dissection of adipose tissue along the anterior and lateral surface of the superior mesenteric vein, however, there are authors who perform circular dissection along the superior mesenteric vessels, considering this extent of surgery to be the most radical. Conclusion. It is necessary to standardize methods and effective criteria for quality control of CME for RCC and LND. In this case, external independent assessment of the quality of surgical intervention is important. There is also currently a growing number of studies in which intraoperative fluorescence imaging makes it possible to better visualize the location of the apical lymph nodes and individualize LND.
Rehabilitation and quality of life of patients after arthroplasty for malignant bone tumors of the upper limb
Authors: Elkhov D. O. , Bukharov A. V. , Erin D. A. , Derzhavin V. A. , Filonenko E. V. , Aliev M. D. , Kaprin A. D.
Published: July 2024

Arthroplasty is the most widely used surgical technique for bone tumors of the upper limbs. However, it should be noted that the functional outcomes after endoprosthetic reconstruction for malignant bone tumors of the upper limb does not always satisfy patients and often lead to impaired working capacity of patients, and their disability. The need to improve functional outcomes determines the practical and socio-economic significance of the research. The purpose of the study was to evaluate the impact of a complex of rehabilitation measures on the quality of life of patients after surgery with endoprosthetic reconstruction for malignant bone tumors of the upper limb. Material and Methods. The treatment and rehabilitation outcomes in 146 patients were analyzed. There were 88 (60 %) men and 58 (40 %) women with an average age of 47 years (range, 19–75 years). The tumor was localized in the proximal humerus in 98 (67 %) patients, in the diaphysis in 18 (12 %), in bones that make up the elbow joint in 16 (11 %) and in the distal radius in 14 (9.6 %) patients. Results. Our rehabilitation technique improved functional outcomes after endoprosthetic reconstruction for all tumor localizations. The musculoskeletal Tumor Society (MSTS) score was improved by 10 % (75 vs 65 %) for arthroplasty of the shoulder joint, for the wrist joint by 8 (80 vs 72 %). The rehabilitation technique allowed significant improvement of MSTS score for arthroplasty of the humeral diaphysis and bones making up the elbow joint (from 76 to 95 % and from 68 to 82 %, respectively). Conclusion. Rehabilitation measures play an important role in optimizing quality of life of patients after surgical treatment of bone tumors of the upper limb with arthroplasty, helping to improve functional outcomes.
Vulvar cancer. The contribution of radiotherapy to the treatment of the disease
Authors: Lushnikova P. A. , Sukhikh E. S. , Startseva Zh. A.
Published: July 2024

The aim of the study was to analyze and summarize the available literature data on the modern radiotherapy techniques, indications for radiotherapy (preoperative, radical, postoperative radiation therapy), treatment volumes at different disease stages, and principles of drug and accompanying therapy for patients with vulvar cancer. Material and Methods. The literature review was based on the clinical recommendations of the Ministry of Health of the Russian Federation and National Comprehensive Cancer Network (NCC N), as well as on the search of sources in PubMed and Cochrane Library systems. Literature sources and publications from 2005 to 2023 were included. Results. This contribution outlined the main indications for preoperative, postoperative and radical radiotherapy in patients with vulvar cancer, as well as the basic principles of drug treatment and correction of complications. Potential risk factors for postoperative disease recurrence were identified, the volumes of irradiation at each treatment mode were analyzed, and the feasibility of using brachytherapy in patients with vulvar cancer was discussed. Conclusion. To date, there are recommendations, guidelines for the management of patients with vulvar cancer, as well as clinical trial results. Understanding of the principles of prescribing treatment for vulvar cancer patients can improve local control, overall and recurrence-free survival, and the use of modern radiotherapy techniques will enshure an acceptable quality of life in these patients.
A rare tumour – metastatic digital papillary adenocarcinoma: literature review, clinical case of successful therapy
Authors: Makarova M. I. , Davydova D. A. , Bogush-Vishnevskaya E. N. , Shcherbakova A. A. , Gamayunov S. V. , Ermolaeva A. M. , Grishakov V. V. , Shumskaia I. S.
Published: July 2024

Digital papillary adenocarcinoma (DPA ) is a rare malignant neoplasm of sweat glands, which was first described by Helwig in 1979 and then classified by Kao in 1987. This disease most often occurs in men aged 50–70 years and is characterized by a relatively favorable prognosis. In most cases, radical excision of the tumor leads to cure. However, 14–47 % of patients develop distant metastases with predominant lung involvement (70 %). The study of etiology and pathogenesis of this rare cancer and its molecular genetic profile seems to be interesting. Currently, there is no clear approach to the treatment of metastatic DPA , but sporadic cases of using chemotherapy have been reported. Aim of the study: to analyze current data on the pathogenesis of DPA , diagnostic features and treatment methods used, as well as to present the first clinical case of treatment of disseminated digital carcinoma with immune checkpoint inhibitors described in scientific literature. Material and Methods. A search of available literature published in Medline, Pubmed, etc. databases from 1984 to 2023 was performed, 21 sources were included in this review. Clinical Case Description. We present a rare case of metastatic digital papillary carcinoma in a 23-year-old male with disease manifestation at the age of 14 years. Lack of vigilance and awareness of oncologists and morphologists did not allow timely diagnosis of malignancy, even in case of 3 local recurrences of the disease. Only biopsy of a metastatic lung nodule with histological and IHC examination (of archival and new material) made it possible to make a correct diagnosis. This case revealed 2 potential targets that could be used for disease control: androgen receptor positive expression and PD -L1 expression with CPS =20. The use of immune response checkpoint inhibitors (ipilimumab + nivolumab) resulted in partial response followed by stable disease.
Criteria for predicting the development of recurrent peripheral nerve sheas tumors
Authors: Orlov A. Yu. , Nazarov A. S. , Dolgushin A. A. , Murzaeva D. A. , Belyakov Yu. V. , Oleynik E. A. , Kudziev A. V. , Zabrodskaya Yu. M.
Published: July 2024

Peripheral nerve sheaths tumors (PNST) account for about 8 % of all nervous system cancers. The relapse rate ranges from 17.3 to 26.4 %, showing an upward trend. The causes and provoking factors for the development of relapses of PNST have not been fully studied. Purpose of the study: to establish criteria for predicting recurrence of PNST. Material and Methods. The study included 122 patients who were treated at the Department of Spine and Peripheral Nerve Surgery of A.I. Polenov Russian Research Neurosurgical Institute from 2009 to 2021. Among them, there were 87 (71.3 %) patients with primary PNST and 35 (28.7 %) patients with recurrent PNST. All patients underwent MRI and ENMG both before and after surgery. An immunohistochemical study of Ki67 and SO X10 markers was performed. Results. The majority of relapses occured within 1 year after surgery. In cases with radical removal of PNST, the risk of relapse was: 28.6 % for schwannomas 28.6 %, 37.1 % for neurofibromas and 34.3 % for MP NST 34.3 % (p≥0.05). The risk of developing relapse of PNST was 2.9 times higher in patients aged ≥49 years than in patients aged ≤48 years (p<0.004). The larger the initial size of the tumor, the higher the risk of relapse in the late postoperative period. The risk of developing relapse of MP NST was 8.79 times higher in patients with tumor size of greater than 11.5 cm than in patients with smaller tumor size (p<0.02). The of Ki67 level above 4.85 % in schwannomas and above 5.17 % in neurofibromas can predict relapse of PNST (p<0.05). Loss of SO X10 protein expression was associated with an increase in histological anaplasia of the tumor, which causes a high risk of relapse and an unfavorable clinical course of the disease. Conclusion. Despite radical (total) resection of PNST, the risk of relapse remains high. The pathological type of tumor, its size, levels of SO X10 and Ki67 markers, patient’s age, degree of preoperative neurological deficit and extent of surgery are significant criteria for predicting the development of relapse of PNST.
Features and outcomes of bilateral anatomical lung resections in patients with lung cancer
Authors: Atyukov M. A. , Zemtsova I. Yu. , Petrov A. S. , Zhemchugova-Zelenova O. A. , Yablonskiy P. K.
Published: July 2024

The aim of this study was to evaluate the feasibility and safety of sequential bilateral anatomical lung resections performed via video-assisted thoracic surgery (VATS) or thoracotomy approaches in lung cancer patients, as well as to identify factors affecting the postoperative period. Material and Methods. Of 534 NSCLC patients undergoing anatomical lung resection in Center for Intensive Pulmonology and Thoracic Surgery from 2014 to 2022, 14 patients with consecutive bilateral anatomical lung resections were included in the retrospective study. The patients were divided into two groups depending on a surgical approach used during the first surgery: group I – 5 patients underwent thoracotomy and group II – 9 patients underwent videoassisted thoracic surgery (VATS). The groups were matched for gender, age, smoking, Charlson Comorbidity Index, lung resection, functional status and stage of the disease. Surgical treatment included anatomical lung resection and ipsilateral systematic lymph dissection. Results. There were significant differences in intraoperative blood loss between the groups. Postoperative complications after surgery on the contralateral lung were observed more often in group 1 patients than in group II patents. The overall 5-year survival rates in patients of groups 1 and 2 were 60 % and 86 %, respectively. Respiratory function indicators three months after surgery corresponded to preoperative prognosis, and their decrease did not depend on the surgical approach used. In comparison with patients who underwent standard unilateral lung resection, bilateral anatomical lung resection was not associated with increased number of “major” complications, however, an increase in the frequency of prolonged air discharge was noted (26 % vs 6 %; p<0.05). Conclusion. Sequential bilateral anatomical lung resections are feasible and safe after thorough preoperative assessment of the functional reserves of the cardio-respiratory system. Mini-invasive technologies make it possible to reduce the frequency of complications in the early postoperative period. The use of the VATS approach makes it possible to safely perform anatomical resection of the contralateral lung.