bluuebunny/crossref_metadata_2025 huggingface dataset:
Small particle drug-eluting beads-transarterial chemoembolization combined with targeted therapy in the clinical treatment of unresectable liver cancer
Authors: Qi Jing-Song , Zhao Peng , Zhao Xiao-Bo , Zhao Yong-Li , Guo Ying-Chang
Published: September 2024

BACKGROUND

Liver cancer is a highly malignant tumor with significant clinical impact. Chemotherapy alone often yields suboptimal outcomes in both the short and long term, characterized by high rates of local recurrence and distant metastasis, leading to a poor long-term prognosis.

AIM

To evaluate the clinical efficacy of small particle drug-eluting beads-transarterial chemoembolization (DEB-TACE) combined with targeted therapy for the treatment of unresectable liver cancer.

METHODS

We analyzed clinical data from 74 patients with unresectable liver cancer admitted between January 2019 and December 2020. Based on the different treatment regimens administered, patients were divided into the control (36 patients receiving sorafenib alone) and joint (38 patients receiving small particle DEB-TACE combined with sorafenib) groups. We compared liver function indicators [alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin (TBIL), albumin (ALB)] and serum tumor markers [alpha fetoprotein (AFP)] before and after treatment in both groups. Short-term efficacy measures [complete response (CR), partial response, progression disease, stable disease, objective response rate (ORR), and disease control rate (DCR)] were assessed post-treatment. Long-term follow-up evaluated median overall survival (OS), progression-free survival (PFS), and adverse reaction rates between the two groups.

RESULTS

One month post-treatment, the joint group demonstrated significantly higher rates of CR, ORR, and DCR compared to the control group (P < 0.05). Three days after treatment, the joint group showed elevated levels of ALT, AST, and TBIL but reduced levels of ALB and AFP compared to the control group (P < 0.05). The median OS was 18 months for the control group and 25 months for the joint group, while the median PFS was 15 months for the control group and 22 months for the joint group, with significant differences observed (log-rank: χ 2 = 7.824, 6.861, respectively; P = 0.005, 0.009, respectively). The incidence of adverse reactions was not significantly different between the groups (P > 0.05).

CONCLUSION

The combination of small particle DEB-TACE and sorafenib significantly improves both short- and long-term outcomes in the treatment of unresectable liver cancer while preserving liver function.
Intratumoural microorganism can affect the progression of hepatocellular carcinoma
Authors: Liu Bao-Qun , Bai Yi , Chen Da-Peng , Zhang Ya-Min , Wang Tian-Ze , Chen Jing-Rui , Liu Xiang-Yu , Zheng Bin , Cui Zi-Lin
Published: September 2024

BACKGROUND

Several recent studies have confirmed that intratumoural microorganisms can affect the occurrence and development of hepatocellular carcinoma (HCC); however, their role in tumor progression remains unclear. Hence, there is a need for further research on the role of intratumoural microorganisms in HCC.

AIM

To investigate the changes in intratumoural microorganisms in HCC and the effect of Propionibacterium on HCC progression.

METHODS

HCC and normal liver tissue specimens were subjected to fluorescence in situ hybridization (FISH). After performing 16S rRNA sequencing on HCC and peritumoral tissues to analyze the differences between the two groups. Propionibacterium was cocultured with HCC cells in vitro . Changes in cell proliferation and migration capacity were evaluated. The expression of NF-κB pathway related proteins in tumor cells was compared. The orthotopic liver implantation model and the subcutaneous xenograft model were constructed. liver tissues and subcutaneous tumors were collected 2 weeks later.

RESULTS

FISH demonstrated the presence of microorganisms in HCC and normal liver tissues. 16S rRNA sequencing revealed an abundance of Lysobacter , Lachnospiraceae , Pseudomonas , and Lactobacillus in HCC tissues. The distribution and abundance of Propionibacterium showed differences between HCC and peritumoral tissues (P < 0.05). In vitro studies demonstrated that Propionibacterium and its metabolite propionic acid (PA) inhibited the proliferation and migration of HCC cells (P < 0.05). The expression of the proteins in NF-κB signaling pathway also decreased in HCC cells (P < 0.05).

CONCLUSION

Microorganisms in HCC and normal liver tissues displayed significant disparities. The PA-producing bacterium Propionibacterium in HCC exerts an effect on the NF-κB pathway, thereby affecting the biological behavior of HCC.
Clinical significance of upregulated Rho GTPase activating protein 12 causing resistance to tyrosine kinase inhibitors in hepatocellular carcinoma
Authors: Wang Xiao-Wei , Tang Yu-Xing , Li Fu-Xi , Wang Jia-Le , Yao Gao-Peng , Zeng Da-Tong , Tang Yu-Lu , Chi Bang-Teng , Su Qin-Yan , Huang Lin-Qing , Qin Di-Yuan , Chen Gang , Feng Zhen-Bo , He Rong-Quan
Published: September 2024

BACKGROUND

Hepatocellular carcinoma (HCC) is a major health challenge with high incidence and poor survival rates in China. Systemic therapies, particularly tyrosine kinase inhibitors (TKIs), are the first-line treatment for advanced HCC, but resistance is common. The Rho GTPase family member Rho GTPase activating protein 12 (ARHGAP12), which regulates cell adhesion and invasion, is a potential therapeutic target for overcoming TKI resistance in HCC. However, no studies on the expression of ARHGAP12 in HCC and its role in resistance to TKIs have been reported.

AIM

To unveil the expression of ARHGAP12 in HCC, its role in TKI resistance and its potential associated pathways.

METHODS

This study used single-cell RNA sequencing (scRNA-seq) to evaluate ARHGAP12 mRNA levels and explored its mechanisms through enrichment analysis. CellChat was used to investigate focal adhesion (FA) pathway regulation. We integrated bulk RNA data (RNA-seq and microarray), immunohistochemistry and proteomics to analyze ARHGAP12 mRNA and protein levels, correlating with clinical outcomes. We assessed ARHGAP12 expression in TKI-resistant HCC, integrated conventional HCC to explore its mechanism, identified intersecting FA pathway genes with scRNA-seq data and evaluated its response to TKI and immunotherapy.

RESULTS

ARHGAP12 mRNA was found to be highly expressed in malignant hepatocytes and to regulate FA. In malignant hepatocytes in high-score FA groups, MDK-[integrin alpha 6 (ITGA6) + integrin β-1 (ITGB1)] showed specificity in ligand-receptor interactions. ARHGAP12 mRNA and protein were upregulated in bulk RNA, immunohistochemistry and proteomics, and higher expression was associated with a worse prognosis. ARHGAP12 was also found to be a TKI resistance gene that regulated the FA pathway. ITGB1 was identified as a crossover gene in the FA pathway in both scRNA-seq and bulk RNA. High expression of ARHGAP12 was associated with adverse reactions to sorafenib, cabozantinib and regorafenib, but not to immunotherapy.

CONCLUSION

ARHGAP12 expression is elevated in HCC and TKI-resistant HCC, and its regulatory role in FA may underlie the TKI-resistant phenotype.
Conversion therapy for unresectable hepatocellular carcinoma: Advances and challenges
Authors: He Yan-Fei
Published: September 2024

Recently, the World Journal of Gastrointestinal Oncology published an article entitled “Pathologically successful conversion hepatectomy for advanced giant hepatocellular carcinoma after multidisciplinary therapy: A case report and review of the literature”, in which the authors shared their successful experience with complete surgical resection after multidisciplinary conversion therapy. The study by Chu et al demonstrates the great challenges that the advanced hepatocellular carcinoma (HCC) poses to surgical oncology, reveals the complexity of conversion therapy for unresectable HCC, emphasizes the important role of a multidisciplinary management model in conversion therapy, and enriches our understanding of the dynamics of personalized treatment for different patients. At present, conversion therapy is a hot research topic in the treatment of unresectable HCC, which has brought new hope to many patients with moderately advanced HCC. However, there are still many urgent problems to be solved in conversion therapy. Here, we would like to further discuss the advances and challenges of conversion therapy for unresectable HCC with the authors and the general readers.
Correction to “Research progress of ferroptosis regulating lipid peroxidation and metabolism in occurrence of primary liver cancer”
Authors: Shu Yu-Jie , Lao Bo , Qiu Ying-Yang
Published: September 2024

Correction to “Research progress of ferroptosis regulating lipid peroxidation and metabolism in occurrence and development of primary liver cancer” in World J Gastrointest Oncol 2024; 16: 2335-2349, published by Shu YJ, Lao B, and Qiu YY. In this article, we added the correct citations of images.
La sombra sucia del asesino en serie, de Virgilio Latorre Latorre. Ed. Tirant lo Blanch, 2024.
Authors: Garrido Vicente
Published: September 2024

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Further Analysis of Economic Innovation Models
Authors: Ngoc Huy Dinh Tran , Dung Pham Anh , Nuong Le Ngoc , Han Le Thi , Sang Do Thi , Ngoc Hien Dinh Tran , Nhan Pham Hung
Published: September 2024

This article focuses on analyzing Further Analysis of Economic Innovation Models in recent years. Method: Methodologies include Qualitative research method: synthesis and inductive methods. Yashoda, et al. (2022) stated that Frugal innovation has become popular in value and implementation of frugal innovations throughout the globe and has shown the benefits it offers to underserved customers in both developing and developed countries. We also expand SWOT model by adding Value part analysis on it. Results: Authors stated opportunities for values adding including but not limit to: levels of R&D will influence benefits/values of global commerce among countries; hence, we need suitable model for sustainable development toward green criteria, as well as transforming smart cities and enhancing connection among urban areas in regions.
Vector bionomic of Culex species in possible Japanese Encephalitis Transmitted areas of Ein-me Township, Ayayawady Region in Myanmar
Authors: Mya Maung Maung , Thaung Sein , Tun Than , Min Oo Sai Zaw , Yee Linn Nay Yee , Oo Tin , Wai Khin Thet , Maung Maung Yan Naung , Htun Zaw Than
Published: September 2024

Japanese encephalitis is a public health problem in many parts of Myanmar. The diseases are transmitted to human by the biting of vector mosquitoes. The study was conducted in JE suspected cases occurred villages ThaPhan Pinseit and ThaPyu Pinseit villages in ThaPhan Pinseit RHC and PaukGone and SarPhyusu villages in PaukGone village in PaukGone RHC from Ayeyawady Region were selected for JE vector surveillance from December 2023 to March 2024. 50 houses from the pigs were randomly selected from each village. Mosquitoes were collected in all selected houses and pig farms using WHO sucking tubes. Larvae were collected in and around 1 Kilometer radius from study sites. Result found that JE main vector Cx. tritaeniorhynchus was abundantly collected in all study village and the highest number of vectors Cx. tritaeniorhynchus was collected from SarPhyusu village 2284 followed by ThaPyu Pinseit 1890 and lowest number of main vectors was collected in ThaPhan Pinseit village (1268). In overall collected mosquitoes, the highest density was found 74.18% of main vector Cx. tritaeniorhynchus followed by suspected vector Cx. vishnui 10.04%, and lowest density was observed Mansonia and An. vagus 0.33% each. Peak biting time of main vector Cx. tritaeniorhynchus was found 9-10 pm. Suspected vector Cx. vishnui was also collected in high number in all villages. Nine species of mosquitoes were collected from the study villages. Of this only four species of An. hyrcanus, An. barbirostris, An. vagus and An. tesellatus were collected. These Anopheles species were available in PaukGone and SarPhyusu villages. Anopheles hyrcanus was collected from all villages. Culex tritaeniorhynchus larvae were abundantly collected from rice fields, polluted water pools and stagnant water pools with plenty of hyacinth plants and also larvae were collected in concrete jars, Bago jars and metal drums water which water was stored for fire water. High density of main vector and suspected vector were collected in all JE suspected villages, pig farms, pigs, and breeding sources of vectors mosquitoes were available in the villages and also JE suspected cases are available in the all villages. This study provides information of high collection of main vector adult and larvae on risk of further transmission in the study areas. Environmental and ecological factors are responsible for the spread of JE virus. Therefore, awareness of community to vector borne diseases control activities and health education to all family members should be strengthened to prevent JE transmission in the villages.
Exploring the Ideosphere: A Comprehensive Examination of Eastern Philosophical Perspectives and Their Societal Reflections
Authors: Sobirovich Turdiev Bekhruz
Published: September 2024

The intellectual heritage of Central Asia during the 9th to 12th centuries represents a golden age of scientific and philosophical achievement, deeply influencing the trajectory of global knowledge. This article delves into the profound contributions of eminent figures from the Eastern Renaissance, including al-Farabi, Abu Rayhan al-Beruni, Abu Ali ibn Sina, Yusuf Khos Hajib, and Nizamulmulk. These scholars not only advanced various scientific disciplines but also profoundly shaped political and philosophical thought. Through a detailed analysis of their works, the article highlights how these thinkers articulated visions for an ideal state that prioritized human dignity and well-being. Their philosophies underscored the importance of justice, the rule of law, and the moral imperative of governance that serves the common good. By examining their emphasis on creating equitable and enlightened societies, the study sheds light on their enduring impact on both regional and global conceptions of statecraft and societal progress. The article further explores how these scholars' ideas on governance and societal development resonate with contemporary discussions on justice and human rights, offering timeless insights into the role of philosophy in shaping humane and effective political systems. Their legacy, deeply rooted in the cultural and intellectual milieu of their time, continues to inspire modern thought and policy-making.
APRENDIZAGEM MEDIADA: O PROJETO INTEGRA E A SINGULARIDADE DO SUJEITO AUTISTA
Authors: Guimarães Lucas , Oliveira Ana Paula Pereira Murkazel de
Published: September 2024

Este estudo tem como objetivo investigar a aplicação dos princípios de intencionalidade, significação e transcendência na mediação pedagógica de crianças autistas, com base na teoria sociocultural de Lev Vygotsky. Reconhecendo a Zona de Desenvolvimento Proximal (ZDP) como um guia para práticas inclusivas nas escolas, buscamos compreender como os educadores podem adaptar suas estratégias de ensino para atender às necessidades individuais desses alunos.Ao analisar a intencionalidade, exploramos como os educadores podem utilizar estímulos sensoriais e estratégias direcionadas para engajar os alunos autistas nas atividades educacionais. Através da significação, investigamos como objetos e atividades podem ser atribuídos de forma significativa, superando estereotipias e facilitando a aprendizagem adaptada. Por fim, na transcendência, examinamos como os educadores podem desafiar os alunos a superar suas limitações e alcançar novos marcos de desenvolvimento. Além disso, discutimos a mediação escolar como uma conquista garantida por lei, destacando sua importância como prática pedagógica fundamentada em princípios teóricos sólidos, visando o desenvolvimento integral dos alunos autistas e sua plena participação na comunidade escolar. Esperamos que este estudo contribua para o aprimoramento das práticas inclusivas nas escolas brasileiras, promovendo uma educação de qualidade e equitativa para todas as crianças, independentemente de suas diferenças individuais.
DIÁLOGOS E PERSPECTIVAS NA EDUCAÇÃO DE JOVENS E ADULTOS
Authors: Purificação Marcelo Máximo , Guerra Avaetê de Lunetta e Rodrigues , Matos Diego de Vargas , Vasconcelos Emanuella Silveira , Júnior Francisco Pires de Castro , Sousa Paulo Santiago de , Oliveira Carlos Alexandre Firme de , Schmidt Jelson Budal , Barros Alessandra Barboza , Joerke Gabriel Antonio Ogaya , Junior Orivaldo da Silva Lacerda , Rego Lucas Barroso , Nascimento Jonael Macedo
Published: September 2024

A Educação de Jovens e Adultos - EJA, atualmente, representa uma nova oportunidade de acesso ao direito à educação, embasada em uma alternativa legal com garantias. O objetivo deste artigo é identificar, sob uma perspectiva ampla e sistêmica da problemática educacional brasileira, como as práticas de educação de jovens e adultos e as reflexões pedagógicas relacionadas têm construído uma trajetória específica. Para realizar o estudo, utilizamos procedimentos metodológicos fundamentados em materiais já existentes na literatura, que possibilitassem a construção de um conhecimento que gerasse um debate genuíno entre diferentes vozes sobre o assunto, levando em conta as perspectivas dos estudiosos e pesquisadores escolhidos para a discussão. Conclui-se que, os diálogos e as perspectivas na educação de jovens e adultos são fundamentais para a promoção de uma educação mais democrática, inclusiva e transformadora. Por meio do diálogo, da escuta ativa e da valorização das diferentes perspectivas, é possível construir práticas pedagógicas mais eficazes e significativas, que contribuam para a formação integral dos sujeitos e para a construção de uma sociedade mais justa e igualitária.
A Comprehensive Review of Machine Learning Approaches in Livestock Health Monitoring
Authors: Sumanth Reddy Shiva , D R Manjunath , S Jahnavi , C Nandini
Published: September 2024

Livestock health monitoring has emerged as a crucial area in agricultural technology, where Machine Learning (ML) approaches offer promising solutions for disease detection, heat stress management, and behavioral anomaly identification. This review explores the latest advancements in applying machine learning models to livestock health monitoring, focusing on methods such as deep learning, IoT integration, and multimodal frameworks. Techniques like Convolutional Neural Networks (CNNs), Long Short-Term Memory (LSTM), and hybrid models have significantly improved early detection of communicable and non-communicable diseases. Additionally, AI-based systems monitoring heat stress and behavioral changes have enhanced overall livestock management, reducing economic losses and improving animal welfare. This review synthesizes current trends and challenges in deploying ML models in real-world farming environments, particularly integrating IoT devices to collect and analyze health data. Moreover, it highlights future directions in improving the accuracy and scalability of ML models, including optimizing data collection and leveraging real-time analytics. This review aims to guide future developments in AI-driven livestock health monitoring systems by providing a comprehensive overview of current research.
In-Flight Sales Prediction Using Machine Learning
Authors: Awoke Habtamu , Kassa Lemlem , Tesfa Tarikwa
Published: September 2024

This study introduces an advanced machine learning approach for predicting in-flight sales, aiming to transform the airline retail landscape. By harnessing advanced algorithms and historical sales data, the proposed model offers precise predictions of passenger preferences, allowing airlines to optimize their in-flight inventory and tailor product offerings more effectively. This data-driven strategy is designed to enhance inventory management, increase ancillary revenue, and improve passenger satisfaction. The research explores six distinct machine learning models: Linear Regression (LR), Support Vector Regression (SVR), Extreme Gradient Boosting (XGBoost), Multilayer Perceptron Neural Network (MLP), Recurrent Neural Network (RNN), and Deep Neural Network (DNN). Among these, XGBoost has proven to be the most effective model for sales forecasting, demonstrating exceptional accuracy and reliability. The study also highlights key features influencing sales, with ItemCategory_ TOBACCO emerging as the most significant factor among all features, and TotalPassenger as the most influential numerical feature. This research not only advances the field of predictive analytics but also provides practical insights for implementation in the aviation industry. As airlines continue to pursue digital transformation, this machine learning solution offers a strategic opportunity to deliver measurable economic benefits and enhance the in-flight retail experience through personalized and relevant product offerings.
Sugarcane Consumption and its Multifaceted Impact on Physiological Parameters: Exploring Associations with Blood Pressure, Blood Glucose Levels, Body Temperature, Breathing Rate, and Urinary Characteristics
Authors: Yousaf Rabbia , Qadir Muhammad Imran , Mehmood Rubaida
Published: September 2024

Background: Sugarcane, a significant agricultural crop, is rich in sucrose, vitamins, and minerals, contributing to nutritional intake. However, the impact of sugarcane consumption on physiological parameters is limited, with previous studies focusing on refined sugar and sugary beverages, leaving a research gap in understanding the specific health effects of sugarcane consumption. The study investigates the impact of sugarcane consumption on various biological parameters, including blood pressure, sugar levels, body temperature, breathing rate, and urine characteristics. Methods: A study involved 200 adult volunteers without pre-existing medical conditions. The participants were divided into two groups: the experimental group, who consumed 250ml of fresh sugarcane juice daily for eight weeks, and the control group, who maintained their regular diet without sugarcane. Blood pressure, glucose levels, body temperature, breathing rate, and urinary characteristics were assessed at baseline and four-week intervals. Data were analyzed using paired t-tests, M-tests, and independent t-tests, and multivariate regression analysis to assess the relationship between sugarcane consumption and physiological parameters. Results: The experimental group exhibited a significant decrease in both systolic and diastolic blood pressure compared to the control group (p < 0.05). Blood glucose levels also showed a modest but statistically significant reduction in the experimental group (p<0.05). No significant differences were observed in body temperature, breathing rate, or urinary characteristics between the two groups. Conclusion: Sugarcane juice consumption in healthy adults showed positive effects on blood pressure and glucose levels over eight weeks, suggesting potential health benefits in managing blood pressure and glycemic control, but further research is needed.
TRANSPOZICIJA KATEGORIJALNE SEME U SUPSTANDARDNIM DEKOMPOZITIMA SRPSKOG JEZIKA
Authors:   University of Kragujevac, Faculty of Philology and Arts, Serbia, Nedeljković Danica B.
Published: September 2024

On the corpus of 3 collections of short humorous stories (columns) by Jelica Greganović (Osmeh za svaki dan, Zovem se mama and Zovem se mama 22), the current paper anal- yses the process of building decomposed linguistic units of a syntagmatic nature (adverbs, adjectives and nouns) in substandard Serbian language by the transposition of the catego- rial seme, either within the same semantic field or in different semantic fields. In this way, very effective and striking linguistic structures are created for pragmatic and stylistic reasons, which means they are conditioned by the linguistic situation and the communicative inten- tions of the speaker, such as achieving the expressiveness of expression and a humorous effect. They are mostly occasional, appear in the substandard, and have the status of a styleme because of their unusual character and great stylistic value.
FRAZEOLOGIJA I PAREMIOLOGIJA U VEČITOM MLADOŽENJI JAKOVA IGNJATOVIĆA
Authors:   Institute for the Serbian Language SASA, Vulović Emonts Nataša S.
Published: September 2024

The phraseologico-paremiological items excerpted from the material of the social novel Confirmed Bachelor (Večiti mladoženja), the most seminal work of the precursor of Serbian realism Jakov Ignjatović, represent the subject of the present research. By applying the method of semantic componential analysis and etymological-historical method in phraseology, we carried out the analysis of individual phrasemes (e.g. начинити од муве медведа (‘make a mountain out of a molehill’), добити корпу (‘get the sack’), постати малим Рочилдом (‘act like Mr Big Shot’). Taking prior linguistic research on the language and style of Jakov Ignjatović into account, it is pointed out that the novel’s phraseological plane predominates the use of phraseological and paremiological items originating from folklore, the ones that possess the specific features of the Serbian linguistic corpus. This testifies to the practice of conventional usage of phraseological and paremiological items among the inhabitants of Szentendre in the 19th century, as well as to the writer’s masterful command of the phraseological stock of the Serbian language.
SLIKOVITA IMENOVANjA U KNjIŽEVNOM STVARALAŠTVU ZA DECU DEJANA ALEKSIĆA
Authors:   University of Kragujevac, Faculty of Education in Jagodina, Serbai, Spasić Jelena Lj.
Published: September 2024

One of the fundamental characteristics of Dejan Aleksić’s literary works for children is play, which is why this multi-awarded children’s writer is considered a successor of Dušan Radović. Proper names in children’s literature do not often have a naming function only, but contribute to the characterization of characters or provide the reader with important infor- mation about the place where the action takes place. The aim of the paper is to show how picturesque names produce an expressive value in different genres of Dejan Aleksic’s literary creation for children. The paper studies the functional significance of antonomasia, kenning, and tmezic puns for the interpretation of literary texts. The analysis was carried out using the linguistic method, and the corpus consists of genre-bending works for children by Dejan Aleksić. The aim of the paper is to point out the stylogenicity of antonomasia, kenning, and tmezic puns in the examined corpus and to show that playing with linguistic structure in names is one of the reasons why we consider Aleksić a new classic, a continuation of not only D. Radović but also J. Jovanović Zmaj, B. Ćopić, D. Maksimović, and Lj. Ršumović, in whose literary works for children we have already analyzed the aforementioned stylistic figures. Picturesque names produced using antonomasia, kenning, and tmezic puns have a very important role for the interpretation of literary texts for children. Antonomasia can give infor- mation about the main characteristics of the character and produce plenty of associations, kenning introduces a child-recipient into the fabula, and the tmezic pun is used to achieve a comic effect.
STAVOVI STUDENATA SRBISTIKE I STUDENATA NEFILOLOŠKE ORIJENTACIJE O PRIHVATLjIVOSTI SOCIJALNIH FEMININATIVA U SAVREMENOM SRPSKOM JEZIKU
Authors:   University of Nis, Faculty of Philosophy, Serbia, Janić Aleksandra N.
Published: September 2024

The subject of this paper is to analyze and interpret the attitudes of Serbian language and literature students and students who are not philologically oriented (Psychology, Pedagogy, Sociology, and Social Politics and Social Work majors) from the Faculty of Philosophy in Niš, Serbia toward the levels of acceptability of social feminatives in contemporary Serbian. The analyzed examples include nouns derived by derivational suffixes -(n)ica (e.g. atašeica ‘attache f.’, naučnica ‘scientist f.’), -ka (e.g. administratorka ‘administrator f.’, akušerka ‘accoucheur f.’), -(k)inja (e.g. avanturistkinja ‘adventurer f.’, stručnjakinja ‘expert f.’), predominantly excerpted from the book Priručnik za upotrebu rodno osetljivog jezika (2019). The main aim was to study the factors that have an influence on the acceptability level of the analyzed social feminatives – the gender of the respondents, their program of study, year of study, and frequency of occur- rence of the gender sensitive language forms in their everyday language use. The respondents were asked to rate their perceived level of acceptability (on a Likert-type scale ranging from 1 – completely unacceptable to 5 – completely acceptable). Average values greater than 3.4 were determined for 66.67% of the analyzed social feminatives, indicating a prevalent level of acceptability among the respondents. However, average values lower than 2.61 were deter- mined just for 7.69% of the analyzed social feminatives. The most acceptable social feminatives on average are the following: šefica ‘boss f.’, ministarka ‘prime minister f.’, urednica ‘editor f.’, načelnica ‘chief f.’, naučnica ‘scientist f.’, reporterka ‘reporter f.’ (an average value above 4.5) and the least acceptable are: sutkinja ‘ judge f ’, atašeica ‘attache f.’, menjačica ‘changer f.’, vojnikinja ‘soldier f.’, lovačica ‘hunter f.’ (an average value below 2.6). A statistically significant differ- ence was noted among the philology students and non-philology students when it came to rating the (un)acceptability of the selected feminatives. Furthermore, a statistically significant difference exists between the complete (un)acceptability of social feminatives among Serbian language and literature students on the one hand, and Sociology, Psychology, and Social Politics and Social Work students on the other. Finally, a statistically significant difference also exists between the acceptability of the selected feminine noun forms ending in the deriva- tional suffix -(k)inja and the selected feminine noun forms ending in the derivational suffixes -(n)ica and -ka.
Mendesain Ulang Keunggulan Kompetitif Organisasi di Era Digital: Peran Strategis Retensi Pengetahuan, Kemampuan Dinamis, dan Bisnis Analitik
Authors: Alanudin Dian , Andriawan Riznandira
Published: September 2024

Revolusi industri keempat ditandai dengan integrasi teknologi digital canggih seperti analisis big data, Internet of Things (IoT), kecerdasan buatan (AI), dan robotika ke dalam proses desain organisasi tradisional. Transformasi ini memicu lonjakan dalam penggunaan internet serta inovasi baru yang secara mendalam memengaruhi cara hidup dan bekerja kita. Untuk tetap bersaing dalam era digital yang berkembang pesat ini, perusahaan perlu mengadopsi desain dan strategi yang lebih mutakhir. Ini mencakup pemanfaatan alat dan platform digital untuk mengoptimalkan operasi, menekan biaya, dan meningkatkan efisiensi. Dengan merombak strategi kompetitif mereka, perusahaan dapat merespons perubahan pasar dengan lebih cepat dan akurat, mendapatkan wawasan lebih dalam tentang perilaku dan preferensi pelanggan, serta mendorong pertumbuhan dan profitabilitas. Dalam konteks bisnis yang serba cepat ini, memperbarui struktur dan proses untuk mencapai kinerja yang lebih baik bukan lagi opsi, melainkan suatu keharusan bagi perusahaan yang ingin maju dalam era digital. Melalui analisis data yang dikumpulkan dari 327 perusahaan e-commerce, studi ini mengusulkan model yang memberikan wawasan praktis dan memperdalam pemahaman tentang faktor-faktor kunci untuk meningkatkan keunggulan kompetitif. Penelitian ini menekankan pentingnya retensi pengetahuan, kapabilitas dinamis, dan adopsi analitik bisnis sebagai elemen strategis dalam mencapai keunggulan di pasar.
Metodologías innovadoras en la enseñanza de la matemática: un análisis sobre la efectividad y barreras emergentes
Authors: Vera Ricardo Otilio Verde , Casas Martin Benedicto Sandoval , Rojas Juan Manuel Pesantes
Published: September 2024

El objetivo del presente artículo fue hacer una revisión sistemática de trabajos existentes para identificar y estudiar metodologías innovadoras en la enseñanza de la matemática, analizando su efectividad para mejorar la comprensión y el rendimiento de los estudiantes. Para llevar a cabo el estudio, se usó una revisión sistemática de la literatura siguiendo las directrices establecida en la declaración PRISMA, en la cual se incluyeron investigaciones de tipo cuantitativo, cualitativo, mixto o de revisión publicadas desde el año 2020 hasta julio de 2024. Se utilizó una combinación de términos de búsqueda relacionados con cualquiera de los dominios de las metodologías innovadoras en la enseñanza de la matemática, incluyendo revisiones sistemáticas previas sobre innovación en la enseñanza de la matemática, alojadas en las bases de datos Scielo y Dialnet, encontrándose un total de 379 artículos. Finalmente, se concluye que las metodologías que integran tecnología, aprendizaje basado en proyectos, enseñanza diferenciada y aprendizaje colaborativo muestran resultados prometedores, pero requieren una implementación más amplia y efectiva, además de una formación continua y apoyo para los docentes.
A Clinical Study of Drakshadi Syrup in Lowering Absolute Eosinophil Count (AEC) and Immunoglobulin E(Ige) Level in Tamak Swash (Bronchial Asthma) in Children
Authors: Ramez Uddin  , Bishnu Prasad sarma
Published: September 2024

Childhood asthma is a prevalent chronic disease worldwide, affecting millions of children. Its impact is not only on the children themselves but also on their families, schools, and healthcare systems. Inspite of all recent advances in modern medical science the prevalence is increasing day by day. Aim: The present study is to assess the response of polyherbal compound ‘Drakshadi Syrup’ in lowering AEC and IgE level in childhood bronchial asthma. Materials and Methods: 106 nos. of patient were registered irrespective of sex between the age group 3-16 years out of which 100 patients completed the trial. Routine blood investigations including basic pathological markers i.e., AEC and IgE were recorded before and after 90 days of treatment. Statistical Tool Used: Paired-t test was done in GraphPad prism 10 software for data analysis. Results and Conclusion: After statistical analysis the t value of AEC was 13.31 with p<.0001 i.e., highly significant and in IgE the t value was 9.73 with p<.0001 i.e., highly significant. It can be concluded that the polyherbal compound is very effective in lowering AEC and IgE levels in childhood bronchial asthma.
Discovering the Efficacy of Integrated Therapies on Chronic Liver Disease
Authors: Acharya Balkrishna  , Kaushalendra Dwivedi  , Anjali Dubey  , Mayur Chauhan  , Jaya Upreti  , Muskan Chauhan  , Prashant Katiyar  , Vedpriya Arya
Published: September 2024

Chronic liver disease (CLD) poses a significant global health challenge and has become a primary cause of mortality worldwide. The development of CLD can be attributed to various factors, such as alcohol abuse, obesity and metabolic disorders, autoimmune hepatitis, and viral hepatitis. This case series explores the clinical journey and combined Ayurvedic treatments used for patients with CLD, aiming to integrate various holistic approaches to enhance overall well-being and potentially achieve remission in CLD. Data were collected at Patanjali Wellness Center, Patanjali Yogpeeth II, Haridwar, from June 2023 to December 2023. In this period of 6 months, we had taken 4 cases of chronic liver disease from IPD. The cases that we found are in the age range of 40 to 60 years. The pre- and post-treatment data on the patient’s outcomes were studied over a period of 6 months, followed by a continuous 3-month follow-up. In this case series, a positive and effective outcome was observed through a holistic strategy. After undergoing treatment, the patient's symptoms showed a noteworthy alleviation of CLD-related symptoms. Simultaneously, the patient's quality of life improved. Their liver function test also showed balanced parameters. At present, they are leading a normal and fulfilling life. The collective impact of these alternative therapies played a significant role in the patient's notable recovery from CLD. Nevertheless, further investigation and exploration are necessary to facilitate larger-scale clinical trials in this area.
Management of Intramural Uterine Fibroid by Ayurveda - A case study
Authors: Geetika  , Jayashree Patil  , Umang Varshney  , Shubham Gupta
Published: September 2024

Too many female gynaecological issues are a result of shifting food habits and lifestyles. One of the main concerns for women who are of reproductive age is uterine fibroids. The symptoms of uterine fibroids have a detrimental effect on women's well-being, their ability to engage in social and physical activities, and their productivity at work. A 25-year-old married female patient arrived at the outpatient clinic complaining of lower abdominal pain, heavy menstrual flow, burning during micturition, and white discharge coming from her vagina six months ago . An intrauterine fibroid measuring 24 x 10 mm size with an ET of 10.5 mm was seen during the ultrasound examination. The ovaries' B/L measurements were normal, and the wall of the gallbladder was slightly enlarged. Surgery was recommended for the same condition, but the patient refused to have it done and preferred non-hormonal treatment. The patient refused to take any allopathic medication. The patient sought Ayurvedic treatment at the OPD. She received treatment in accordance with the Ayurvedic regimen prescribed by Kanchanar Guggulu, Kuberaksha vati, Raktavardhak vati, Ashoka-arishta, Hingwashtak churna, Chandraprabha vati, Kumaryaasawa.After three months of treatment and a follow-up every 15 days, a repeat scan showed normal results and symptom alleviation.
An Ayurvedic Approach of Ahiputana with Special Reference to Napkin Dermatitis: A Literature Review
Authors: Umang Varshney  , Sachin Bhagwat  , Geetika  , Shubham Gupta
Published: September 2024

Ahiputana is mentioned in Kshudraroga in Ayurveda. A mother who neglects her child may cause them to suffer from a variety of illnesses, among them is Ahiputana. Diaper dermatitis, also known as napkin dermatitis, is one of the most prevalent skin ailments in young children and infants. Pediatric OPD frequently deals with Ahiputana, also known as napkin dermatitis. The Guda region (Napkin region) is home to several diseases that are described in the Ayurved Samhita, including Ahiputana, Anamika, Sannirudhguda, Parikartika, Gudabhransh, and Gudakutta. All Samhita’s explained Ahiputana as a skin condition that primarily affects the Pitta, Kapha, and Rakta doshas and is typically observed in young children and newborns. Poor hygiene and sweat retention causes ammonia to build up, which causes blistering rashes in the skin of anal area. According to the Ayurvedic Samhita, one of the causes of Ahiputana is stanyadushti. Depending on the Doshas involved and the state of the rash, the treatment plan may include avoidance of causes, Stanya shodhana, local applications, decoctions for cleaning, powders for dusting, and other methods. A deeper understanding of napkin dermatitis and Ahiputana will undoubtedly pave the way for the creation of better management guidelines that can provide newborns with a great deal of relief. As a result, this paper presents a complete evaluation of Ahiputana and Napkin dermatitis.
Comparative Cost Analysis of Hypercholesterolemia Treatment: Allopathic Medicine and Ayurveda Medicine
Authors: Sunil Kumar  , Piyush Yadav  , Binay Sen  , L.P. Meena  , Anoop Misra  , Aparnesh Pandey
Published: September 2024

The cost of treatment is very high for CVD and the prevalence of hypercholesterolemia is also very high in developing countries. Many Indian people do not have basic amenities and medical facilities are also not accessible. So alternative medicine can play an important role in the treatment of high cholesterol. Arjuna and Kutki are effective medicines in treating high cholesterol. Methodology: Comparative cross sectional study was planned to determine the socio-economic, and demographic status and comparison of treatment costs of high cholesterol patients in SS Hospital, IMS, BHU, Varanasi. Result: The overall expenditure for Group B is significantly high (3670.06) compared to Group A (1341.10). Medicine costs form the largest portion of expenses in Group B (1:4.8), while laboratory costs are the largest in Group A. Discussion: The economic burden poses a significant challenge in the treatment of any illness. Elevated cholesterol levels pose a significant problem in the current state of affairs in India. Developing countries face significant challenges in managing their financial issues.
Yashadamritamalaharam Application in the Management of Parikarthika - A Comprehensive Analytical Review
Authors: Aparna.M  , Arya.S. Menon  , Vasudeva Reddy
Published: September 2024

Parikartika is one among the anorectal diseases, which can be correlated with fissure in ano in the contemporary medicine. Parikartika is a disease condition rather than a single entity disease, which is usually triggered by other factors as per Ayurveda classics. It is usually described as a very painful condition which mostly affects the quality living. The disease pathology should be analyzed, studied and appropriate therapeutic measures should be advised to tackle and prevent the recurrence. There are many therapeutic methods available today for the treatment of Parikartika both in modern and Ayurveda. Modern methods are no replace oral pain medications, topical ointments, botulin injections surgical interventions etc. These have usually side effects and cause inconvenience to the patients. Ayurvedic preparations are also very effective, out of which a convenient, patient friendly easy method must be chosen. Yashadamrita malahara is a Malahara preparation from classical rasa text Rasatarangini which has wound healing properties which can be applied as an ointment or as Pichu. Aims and Objectives: This is an in-depth review analysis of Parikartika samprapti and the effect of Yashadamrita malahara in the management of the disease. Materials and methods: An attempt has been made to analyze the Samprapti ghatakas of Parikartika and the pharmacological actions of Yashadamrita malahara, and to explain the probable mode of action of the drug in the disease. Discussion and conclusion: Evaluation of the effect of Yashadamrita malahara and its therapeutic benefits in Parikartika by its mode of action.
Pharmaceutical Preparation and Preliminary Analysis of Shweta Parpati Mentioned in Different Classics
Authors: Puneeth Raj R.M  , Anupam Srivastava  , Sakhitha K.S.  , Mohar Pal Meena  , Reetesh Ramnani
Published: September 2024

Rasa Shastra, a crucial branch of Ayurveda, emphasizes the therapeutic applications of herbo-mineral and metallic preparations. Shweta Parpati (SP), mentioned in many Ayurvedic classics, is renowned for treating conditions such as Mutrakricchra (urinary problems), Ashmari (renal stones), Yakritvikara (hepatic disorders) etc. This study aims to prepare and evaluate five different samples of SP based on classical references to ensure their quality and difficulties in pharmaceutical preparation. Materials and Methods: Five methods selected from texts like Siddhabheshajamanimala (SBM), Bhaishajya ratnavali (BR), Rastantrasaar & Siddhaprayoga Sangraha (RTSSPS), Siddhayogasangraha (SYS), Rasoddharatantra (RDT) were followed, utilizing Suryakshara (potassium nitrate), Sphatika (potash alum), Gandaka (sulphur), Navasadara (ammonium chloride), Tankana (borax), Karpura (camphor), and Gandaka ka shudda tijab (sulfuric acid) in different proportions, pharmaceutical steps, and ingredient combinations. Ingredients were meticulously processed, heated, and solidified under controlled conditions. Yield and analytical parameters of each formulation were recorded according to API reference. Results: SBM reference produced brittle flakes with brownish spots, yielding 71.42%. BR resulted in very hard flakes with 54.66% yield. RTSSPS achieved thin, brittle flakes with nearly 89.77% yield. SYS produced hard flakes, yielding 73.68%. RDT yielded arduous flakes with a 69.85% yield. Analytical results showed significant variations in physicochemical properties, highlighting the diverse impacts of these traditional texts on preparation techniques. Conclusion: Standardizing these methods is essential to ensure consistency and reliability in clinical applications. Future research should focus on refining these techniques and exploring their clinical benefits in more depth.
A Case Study of Nidranasha and its Management Through Ayurveda
Authors: Sawle Megha  , Varghese Jibi
Published: September 2024

Ayurveda has described various preventions as well as cure for every disorder. This all helps in maintaining health of an individual. Ayurveda has mentioned Aahara, Nidra, Brahmacharya are the three main pillars of body. Nidra is essential in every person’s life. Here Nidra is explained as one of the important part of life which provides Sukha, Dukha etc. Ayurveda has mentioned that lack of Nidra causes ‘Nidranasha’. According to Ayurveda, Nidranasha i.e., insomnia classified under the Vatananatmaja Vikara. There are various treatments and Kalpas etc. available for the management of Nidranasha. In this case report of Nidranasha patient was treated with Ayurvedic management with Shodhana and Shamana Chikitsa. Shirodhara helps to relieve the stress, along with reduces Chinta, etc Manasa Bhava.
Psicopedagogia aplicada ao ensino de geografia: superando barreiras de aprendizagem
Authors: Seccatto Ana Gláucia
Published: September 2024

O presente artigo é parte de um trabalho de conclusão de curso de especialização em Psicopedagogia e busca refletir sobre as contribuições das abordagens psicopedagógicas para o ensino de Geografia, analisando seus subsídios para a identificação e implementação de estratégias mais eficazes para alunos com dificuldades de aprendizagem. Ao explorar a interseção entre psicologia e pedagogia, a psicopedagogia oferece uma abordagem integrada para identificar e abordar barreiras à aprendizagem, promovendo um ambiente escolar mais inclusivo e propício ao desenvolvimento cognitivo e socioemocional dos alunos. Para atingir os objetivos propostos, foram realizadas pesquisas bibliográficas e atividades com viés psicopedagógico aplicadas nas aulas de Geografia de uma escola pública no município de Fátima do Sul-MS. Como resultado das atividades propostas, ficou perceptível que o aprendizado se tornou mais prazeroso e significativo para os estudantes, além de possibilitar sua participação ativa no processo de construção de seus conhecimentos geográficos.
Extracellular vesicles of different bacterial and eukaryotic origin The Erlangen Vesicles
Authors: Arnold Philipp , Günther Claudia , Fuhrmann Gregor
Published: September 2024

State of the art research on extracellular vesicles (EVs) that adheres to the guidelines provided by the International Society for Extracellular Vesicles (ISEV), demands expertise in different biochemical, imaging and biophysical methods. Additionally, it became clear in recent years that scientific questions related to EV touch many different research fields. This diverse methodological and scientific framework has led to increased network formation within the EV community in recent years. Various national and international initiatives were established to bring EV scientists together and develop joint research concepts. This has led, for example, to various national EV societies, of which GSEV is one. These national societies are very successful in providing platforms to discuss overarching goals and foster yearly exchange of research at annual society meetings.