An optimised procedure for histological assessment of cartilage damage
Authors:   Department of Traumatology and Orthopaedics, 110 Military Hospital, 7 Tran Luu Street, Thi Cau Ward, Bac Ninh City, Bac Ninh Province, Vietnam, Dang Van Huy ,   108 Insititute of Clinical Medicine and Pharmacy, 1 Tran Hung Dao Street, Bach Dang Ward, Hai Ba Trung District, Hanoi, Vietnam, Nguyen The Hoang ,   108 Insititute of Clinical Medicine and Pharmacy, 1 Tran Hung Dao Street, Bach Dang Ward, Hai Ba Trung District, Hanoi, Vietnam, Ngo Thi Minh Hanh ,   Department of Pathology,108 Military Central Hospital, 1 Tran Hung Dao Street, Bach Dang Ward, Hai Ba Trung District, Hanoi, Vietnam, Nguyen Thi Ngoc Anh ,   Department of Pathology,108 Military Central Hospital, 1 Tran Hung Dao Street, Bach Dang Ward, Hai Ba Trung District, Hanoi, Vietnam, Pham Cong Nguyen ,   Center of Stem Cell Research and Application, 108 Military Central Hospital, 1 Tran Hung Dao Street, Bach Dang Ward, Hai Ba Trung District, Hanoi, Vietnam,   The Vietnamese-German Center for Medical Research,108Military Central Hospital, 1 Tran Hung Dao Street, Bach Dang Ward, Hai Ba Trung District, Hanoi, Vietnam, Nguyen Hai Anh ,   Center of Stem Cell Research and Application, 108 Military Central Hospital, 1 Tran Hung Dao Street, Bach Dang Ward, Hai Ba Trung District, Hanoi, Vietnam,   The Vietnamese-German Center for Medical Research,108Military Central Hospital, 1 Tran Hung Dao Street, Bach Dang Ward, Hai Ba Trung District, Hanoi, Vietnam, Le Huu Phuong Anh ,   Center of Stem Cell Research and Application, 108 Military Central Hospital, 1 Tran Hung Dao Street, Bach Dang Ward, Hai Ba Trung District, Hanoi, Vietnam,   The Vietnamese-German Center for Medical Research,108Military Central Hospital, 1 Tran Hung Dao Street, Bach Dang Ward, Hai Ba Trung District, Hanoi, Vietnam, Nguyen Duc Luong ,   Center of Stem Cell Research and Application, 108 Military Central Hospital, 1 Tran Hung Dao Street, Bach Dang Ward, Hai Ba Trung District, Hanoi, Vietnam, Nguyen Kim Anh ,   Center of Stem Cell Research and Application, 108 Military Central Hospital, 1 Tran Hung Dao Street, Bach Dang Ward, Hai Ba Trung District, Hanoi, Vietnam,   The Vietnamese-German Center for Medical Research,108Military Central Hospital, 1 Tran Hung Dao Street, Bach Dang Ward, Hai Ba Trung District, Hanoi, Vietnam, Nguyen Ngoc Mai ,   Center of Stem Cell Research and Application, 108 Military Central Hospital, 1 Tran Hung Dao Street, Bach Dang Ward, Hai Ba Trung District, Hanoi, Vietnam,   The Vietnamese-German Center for Medical Research,108Military Central Hospital, 1 Tran Hung Dao Street, Bach Dang Ward, Hai Ba Trung District, Hanoi, Vietnam, Dao Huy Hoang ,   Center of Stem Cell Research and Application, 108 Military Central Hospital, 1 Tran Hung Dao Street, Bach Dang Ward, Hai Ba Trung District, Hanoi, Vietnam, Nguyen Huu Giap ,   Department of Diagnostic X-Ray,Department of Diagnostic Imaging, 108 Military Central Hospital, 1 Tran Hung Dao Street, Bach Dang Ward, Hai Ba Trung District, Hanoi, Vietnam, Ngo Thu Huong ,   Department of Arthroplasty, 108 Military Central Hospital,1 Tran Hung Dao Street, Bach Dang Ward, Hai Ba Trung District, Hanoi, Vietnam, Truong Van Ha ,   Department of Arthroplasty, 108 Military Central Hospital,1 Tran Hung Dao Street, Bach Dang Ward, Hai Ba Trung District, Hanoi, Vietnam, Tran Thi Huyen Trang ,   Center of Stem Cell Research and Application, 108 Military Central Hospital, 1 Tran Hung Dao Street, Bach Dang Ward, Hai Ba Trung District, Hanoi, Vietnam,   The Vietnamese-German Center for Medical Research,108Military Central Hospital, 1 Tran Hung Dao Street, Bach Dang Ward, Hai Ba Trung District, Hanoi, Vietnam
Published: August 2024

Cartilage damage is often caused by degeneration and injury. Delaying detection and treatment can exacerbate degeneration, leading to impaired joint function. Due to the avascular and nerveless nature of cartilage tissue, completely repairing hyaline cartilage remains a challenge for researchers. Besides, assessing the damage grades and the effectiveness of treatment for cartilage damage is very important.Despite various non-invasive longitudinal monitoring methods such as ultrasound and magnetic resonance imaging, histopathology remains the “gold standard” for assessing joint cartilage quality. However, research on cartilage histopathology in Vietnam is still not commonly conducted. This research aims to establish an efficient, implementable, and reliable evaluation process for cartilage histopathology in humans and experimental animals.