bluuebunny/crossref_metadata_2025 huggingface dataset:
Effects of and satisfaction with short message service reminders for patient medication adherence: a randomized controlled study
Authors: Huang Hsiu-Ling , Li Yu-Chuan Jack , Chou Yueh-Ching , Hsieh Yow-Wen , Kuo Frank , Tsai Wen-Chen , Chai Sinkuo Daniel , Lin Blossom Yen-Ju , Kung Pei-Tseng , Chuang Chia-Jung
Published: November 2013

Background

Medication adherence is critical for patient treatment. This study involved evaluating how implementing Short Message Service (SMS) reminders affected patient medication adherence and related factors.

Methods

We used a structured questionnaire to survey outpatients at three medical centers. Patients aged 20 years and older who were prescribed more than 7 days of a prescription medication were randomized into SMS intervention or control groups. The intervention group received daily messages reminding them of aspects regarding taking their medication; the control group received no messages. A phone follow-up was performed to assess outcomes after 8 days. Data were collected from 763 participants in the intervention group and 435 participants in the control group.

Results

After participants in the intervention group received SMS reminders to take medication or those in the control group received no messages, incidences of delayed doses were decreased by 46.4 and 78.8% for those in the control and intervention groups, respectively. The rate of missed doses was decreased by 90.1% for participants in the intervention group and 61.1% for those in the control group. We applied logistic regression analysis and determined that participants in the intervention group had a 3.2-fold higher probability of having a decrease in delayed doses compared with participants in the control group. Participants in the intervention group also showed a 2.2-fold higher probability of having a decrease in missed doses compared with participants in the control group.

Conclusions

Use of SMS significantly affected the rates of taking medicine on schedule. Therefore, daily SMS could be useful for reminding patients to take their medicine on schedule.
Factors in the management of feeding in nursery school children as perceived by their mothers in rural Bondo County, Kenya
Authors: Were Allan R , Kioli Felix N , Onkware Kennedy , Onyango Elizabeth O , Gumo Sussy , Ouma Collins
Published: November 2013

Background

The effects of malnutrition on health status and survival of children has been the subject of extensive research for several decades. Malnutrition affects physical growth, cognitive development of children, morbidity and mortality. The current study was an exploratory survey that focused on factors affecting feeding of nursery school children as perceived by their mothers in a rural setting in Usigu Division of Bondo County, Kenya.

Methods

The sampling frame was mothers whose children were in Kanyibok, Sanda and Usenge nursery schools. Purposive sampling methods were used to draw a total of 108 respondents. In a logistic regression model, bad management of feeding was the dependent variable while factors perceived to affect management of feeding were the independent variables.

Results

Married mothers were more likely to manage good feeding practices (OR, 0.34, 95% CI, 0.21-0.76; P = 0.022) relative to those who were single or widowed. Additional analyses showed that low education levels (OR, 7.33, 95% CI, 3.37-12.91; P = 0.023), younger mothers (OR, 6.04, 95% CI, 3.22-9.68; P = 0.029) and mothers engaged in business (OR, 4.02, 95% CI, 2.11-7.85; P = 0.027) increased their likelihood of not feeding the pre-school children. Majority of the children who ate the main meals in other houses belonged to young mothers in the age category of 15–29 years. Further analyses demonstrated that if the order of serving food was to the children first, then they had high likelihood of having good feeding relative to when the father was served first (OR, 0.22, 95% CI, 0.14-0.61; P = 0.011).

Conclusions

Based on these findings, there is an urgent need for sensitization of the mothers on the management of feeding of these pre-school children in Bondo County. It is hoped that relevant interventions would then be designed with the view of managing children feeding in such rural settings as in Bondo County in Kenya.
Reduced beta2-glycoprotein I protects macrophages from ox-LDL-induced foam cell formation and cell apoptosis
Authors: Wang Wei-Lin , Meng Zhen-Xing , Zhou Sai-Jun , Li Chun-Jun , Chen Rui , Lv Lin , Ma Ze-Jun , Yu De-Min , Yu Pei
Published: November 2013

Background

Reduced beta2-glycoprotein I (beta2-GPI) is a free thiol-containing form of beta2-GPI that displays a powerful effect in protecting endothelial cells from oxidative stress-induced cell death. The present study aims to investigate the effect of beta2-GPI or reduced beta2-GPI on ox-LDL-induced foam cell formation and on cell apoptosis and to determine the possible mechanisms.

Methods

The RAW264.7 macrophage cell line was selected as the experimental material. Oil red O staining and cholesterol measurement were used to detect cholesterol accumulation qualitatively and quantitatively, respectively. Flow cytometry was used to detect cell apoptosis. Real-time quantitative PCR was used to detect the mRNA expression of the main proteins that are associated with the transport of cholesterol, such as CD36, SRB1, ABCA1 and ABCG1. Western blot analysis was used to detect the protein expression of certain apoptosis-related proteins, such as caspase-9, caspase-3, p38 MAPK/p-p38 MAPK and JNK/p-JNK.

Results

Beta2-GPI or reduced beta2-GPI decreased ox-LDL-induced cholesterol accumulation (96.45 ± 8.51 μg/mg protein vs. 114.35 ± 10.38 μg/mg protein, p < 0.05;74.44 ± 5.27 μg/mg protein vs. 114.35 ± 10.38 μg/mg protein, p < 0.01) and cell apoptosis (30.00 ± 5.10% vs. 38.70 ± 7.76%, p < 0.05; 20.66 ± 2.50% vs. 38.70 ± 7.76%, p < 0.01), and there are significant differences between beta2-GPI and reduced beta2-GPI (p < 0.05). Reduced beta2-GPI decreased the ox-LDL-induced expression of CD36 mRNA and ABCA1 mRNA (p < 0.05), as well as CD36, cleaved caspase-9, cleaved caspase-3, p-p38 MAPK and p-JNK proteins (p < 0.05 or p < 0.01). Beta2-GPI did not significantly decrease the expression of ABCA1 mRNA and the p-p38 MAPK protein.

Conclusions

Both beta2-GPI and reduced beta2-GPI inhibit ox-LDL-induced foam cell formation and cell apoptosis, and the latter exhibits a stronger inhibition effect. Both of these glycoproteins reduce the lipid intake of macrophages by downregulating CD36 as well as protein expression. Reduced beta2-GPI inhibits cell apoptosis by reducing the ox-LDL-induced phosphorylation of p38 MAPK and JNK, and the amount of cleaved caspase-3 and caspase-9. Beta2-GPI does not inhibit the ox-LDL-induced phosphorylation of p38 MAPK.
Mek inhibition results in marked antitumor activity against metastatic melanoma patient-derived melanospheres and in melanosphere-generated xenografts
Authors: Sette Giovanni , Fecchi Katia , Salvati Valentina , Lotti Fiorenza , Pilozzi Emanuela , Duranti Enrico , Biffoni Mauro , Pagliuca Alfredo , Martinetti Daniela , Memeo Lorenzo , Milella Michele , De Maria Ruggero , Eramo Adriana
Published: November 2013

One of the key oncogenic pathways involved in melanoma aggressiveness, development and progression is the RAS/BRAF/MEK pathway, whose alterations are found in most patients. These molecular anomalies are promising targets for more effective anti-cancer therapies. Some Mek inhibitors showed promising antitumor activity, although schedules and doses associated with low systemic toxicity need to be defined. In addition, it is now accepted that cancers can arise from and be maintained by the cancer stem cells (CSC) or tumor-initiating cells (TIC), commonly expanded in vitro as tumorspheres from several solid tumors, including melanoma (melanospheres). Here, we investigated the potential targeting of MEK pathway by exploiting highly reliable in vitro and in vivo pre-clinical models of melanomas based on melanospheres, as melanoma initiating cells (MIC) surrogates. MEK inhibition, through PD0325901, provided a successful strategy to affect survival of mutated-BRAF melanospheres and growth of wild type-BRAF melanospheres. A marked citotoxicity was observed in differentated melanoma cells regardless BRAF mutational status. PD0325901 treatment, dramatically inhibited growth of melanosphere-generated xenografts and determined impaired tumor vascularization of both mutated- and wild type-BRAF tumors, in the absence of mice toxicity. These results suggest that MEK inhibition might represent a valid treatment option for patients with both mutated- or wild type-BRAF melanomas, affecting tumor growth through multiple targets.
Abdominal adiposity, insulin resistance, and oxidized low-density lipoproteins in Latino adolescents
Authors: Ryder Justin R , Vega-López Sonia , Djedjos Constantine S , Shaibi Gabriel Q
Published: November 2013

Abdominal obesity and insulin resistance (IR) place youth at higher risk for premature cardiovascular disease (CVD), but the underlying mechanisms are not clear. In adults, abdominal obesity and IR contribute to the oxidation of low-density lipoprotein (LDL). Whether similar mechanisms are operational in Latino adolescents is unknown. Therefore, we determined whether IR and abdominal adiposity are associated with higher oxLDL concentrations in Latino adolescents. Data from 123 Latino adolescents (16.3 ± 2.5 years; female = 74) were used for the present analysis. Participants were assessed for waist circumference, fasting serum oxLDL, and insulin sensitivity by the whole body insulin sensitivity index. In separate linear regression models adjusting for age and sex, both waist circumference and insulin sensitivity were significant predictors of oxLDL (β = 1.9; p = 0.002; R2 = 0.13, β = -1.7; p = 0.006; R2 = 0.11, respectively). When insulin sensitivity and waist circumference were included in the same model, both remained independent predictors of oxLDL (β = 1.7; p = 0.016 and, β = -1.5; p = 0.055, respectively; R2 = 0.16). These results suggest that insulin resistance and abdominal adiposity are associated with higher levels of LDL oxidation which may be a mechanism contributing to increased CVD risk in Latino adolescents.
Noninvasive k3 estimation method for slow dissociation PET ligands: application to [11C]Pittsburgh compound B
Authors: Sato Koichi , Fukushi Kiyoshi , Shinotoh Hitoshi , Shimada Hitoshi , Hirano Shigeki , Tanaka Noriko , Suhara Tetsuya , Irie Toshiaki , Ito Hiroshi
Published: November 2013

Background

Recently, we reported an information density theory and an analysis of three-parameter plus shorter scan than conventional method (3P+) for the amyloid-binding ligand [11C]Pittsburgh compound B (PIB) as an example of a non-highly reversible positron emission tomography (PET) ligand. This article describes an extension of 3P + analysis to noninvasive ‘3P++’ analysis (3P + plus use of a reference tissue for input function).

Methods

In 3P++ analysis for [11C]PIB, the cerebellum was used as a reference tissue (negligible specific binding). Fifteen healthy subjects (NC) and fifteen Alzheimer's disease (AD) patients participated. The k
3 (index of receptor density) values were estimated with 40-min PET data and three-parameter reference tissue model and were compared with that in 40-min 3P + analysis as well as standard 90-min four-parameter (4P) analysis with arterial input function. Simulation studies were performed to explain k
3 biases observed in 3P++ analysis.

Results

Good model fits of 40-min PET data were observed in both reference and target regions-of-interest (ROIs). High linear intra-subject (inter-15 ROI) correlations of k
3 between 3P++ (Y-axis) and 3P + (X-axis) analyses were shown in one NC (r
2 = 0.972 and slope = 0.845) and in one AD (r
2 = 0.982, slope = 0.655), whereas inter-subject k
3 correlations in a target region (left lateral temporal cortex) from 30 subjects (15 NC + 15 AD) were somewhat lower (r
2 = 0.739 and slope = 0.461). Similar results were shown between 3P++ and 4P analyses: r
2 = 0.953 for intra-subject k
3 in NC, r
2 = 0.907 for that in AD and r
2 = 0.711 for inter-30 subject k
3. Simulation studies showed that such lower inter-subject k
3 correlations and significant negative k
3 biases were not due to unstableness of 3P++ analysis but rather to inter-subject variation of both k
2 (index of brain-to-blood transport) and k
3 (not completely negligible) in the reference region.

Conclusions

In [11C]PIB, the applicability of 3P++ analysis may be restricted to intra-subject comparison such as follow-up studies. The 3P++ method itself is thought to be robust and may be more applicable to other non-highly reversible PET ligands with ideal reference tissue.
Novel user centric, game theory based bandwidth allocation mechanism in WiMAX
Authors: Algur Siddu P , Kumar Niharika P
Published: November 2013

Bandwidth allocation plays a crucial role in ensuring overall quality of service in WiMAX. WiMAX supports non-contention based bandwidth allocation mechanism, where the responsibility of bandwidth allocation lies with the base station. In this paper, a novel user- centric, Game Theory-based bandwidth allocation algorithm is proposed. The Users/Mobile Station shall be grouped in pairs and bandwidth allocation is performed alternately between the two users of a group. In any given frame only one user from a pair is allocated bandwidth. The bandwidth thus allocated shall satisfy the requirements of the user/mobile station for two consecutive frames. Since, in any given frame, only one user/MS is allocated the bandwidth, the proposed algorithm reduces the frame overhead, thereby saving precious bandwidth that can be utilized to improve throughput. Simulation results show a 50% decrease in the uplink frame overhead and about 8% improvement in the uplink throughput per user/mobile station.
Qualitative Analysis of Practicing Oncologists' Attitudes and Experiences Regarding Collection of Patient-Reported Outcomes
Authors: Jagsi Reshma , Chiang Anne , Polite Blase N. , Medeiros Bruno C. , McNiff Kristen , Abernethy Amy P. , Zon Robin , Loehrer Patrick J.
Published: November 2013

When introduced to the concept of patient-reported outcomes, practicing oncologists recognized utility in improving the efficiency and thoroughness of the patient encounter if implemented properly.
Improving Quality of Cancer Care at Community Hospitals: Impact of the National Cancer Institute Community Cancer Centers Program Pilot
Authors: Halpern Michael T. , Spain Pamela , Holden Debra J. , Stewart Andrew , McNamara Erica J. , Gay Greer , Prabhu Das Irene , Clauser Steven
Published: November 2013

Both NCCCP and comparison-group hospitals showed improved quality of care; however, NCCCP sites had significantly greater improvements in a subset of measures, which may reflect the multidisciplinary focus of the NCCCP.
Shared Vision, Collective Impact, and Persistent Challenges: The First Decade of Georgia's Oncology Research Network
Authors: Paris Nancy M. , Burke James J. , Schnell Frederick M.
Published: November 2013

The authors describe the first 10 years of the research network developed by the Georgia Center for Oncology Research and Education.
Overcoming Recruitment Challenges in Palliative Care Clinical Trials
Authors: LeBlanc Thomas W. , Lodato Jordan E. , Currow David C. , Abernethy Amy P.
Published: November 2013

Challenges to clinical trial recruitment in palliative care are significant but not insurmountable. Through their experience with designing and deploying a social-marketing based protocol, the authors show that a carefully crafted recruitment and retention protocol can be effective.
Improving Communication Between Oncologists and Reproductive Specialists to Promote Timely Referral of Patients With Cancer
Authors: Vadaparampil Susan T. , Quinn Gwendolyn P.
Published: November 2013

By empowering oncology care providers to facilitate discussion and referral of patients of reproductive age, the updated 2013 ASCO Guidelines provide an opportunity to strengthen communication between oncology care providers and their reproductive specialist colleagues.
The National Cancer Institute–American Society of Clinical Oncology Cancer Trial Accrual Symposium: Summary and Recommendations
Authors: Denicoff Andrea M. , McCaskill-Stevens Worta , Grubbs Stephen S. , Bruinooge Suanna S. , Comis Robert L. , Devine Peggy , Dilts David M. , Duff Michelle E. , Ford Jean G. , Joffe Steven , Schapira Lidia , Weinfurt Kevin P. , Michaels Margo , Raghavan Derek , Richmond Ellen S. , Zon Robin , Albrecht Terrance L. , Bookman Michael A. , Dowlati Afshin , Enos Rebecca A. , Fouad Mona N. , Good Marjorie , Hicks William J. , Loehrer Patrick J. , Lyss Alan P. , Wolff Steven N. , Wujcik Debra M. , Meropol Neal J.
Published: November 2013

In 2010, the National Cancer Institute and the American Society of Clinical Oncology cosponsored a symposium to examine the state of clinical trial accrual science and identify opportunities to facilitate trial enrollment. The authors provide recommendations for best practices and for future research developed from the symposium.
Minireview: Intraislet Regulation of Insulin Secretion in Humans
Authors: Rutter Guy A. , Hodson David J.
Published: November 2013

The higher organization of β-cells into spheroid structures termed islets of Langerhans is critical for the proper regulation of insulin secretion. Thus, rodent β-cells form a functional syncytium that integrates and propagates information encoded by secretagogues, producing a “gain-of-function” in hormone release through the generation of coordinated cell-cell activity. By contrast, human islets possess divergent topology, and this may have repercussions for the cell-cell communication pathways that mediate the population dynamics underlying the intraislet regulation of insulin secretion. This is pertinent for type 2 diabetes mellitus pathogenesis, and its study in rodent models, because environmental and genetic factors may converge on these processes in a species-specific manner to precipitate the defective insulin secretion associated with glucose intolerance. The aim of the present minireview is therefore to discuss the structural and functional underpinnings that influence insulin secretion from human islets, and the possibility that dyscoordination between individual β-cells may play an important role in some forms of type 2 diabetes mellitus.
Evaluation of visible implant elastomer tags in zebrafish (Danio rerio)
Authors: Hohn Claudia , Petrie-Hanson Lora
Published: November 2013

The use of the visible implant elastomer (VIE) tagging system in zebrafish (Danio rerio) was examined. Two tag orientations (horizontal and vertical) at the dorsal fin base were tested for tag retention, tag fragmentation and whether VIE tags affected growth and survival of juvenile zebrafish (1–4 month post hatch). Six tag locations (abdomen, anal fin base, caudal peduncle, dorsal fin base, pectoral fin base, isthmus) and 5 tag colors (yellow, red, pink, orange, blue) were evaluated for ease of VIE tag application and tag visibility in adult zebrafish. Long-term retention (1 year) and multiple tagging sites (right and left of dorsal fin and pectoral fin base) were examined in adult zebrafish. Lastly, survival of recombination activation gene 1−/− (rag1−/−) zebrafish was evaluated after VIE tagging.

The best tag location was the dorsal fin base, and the most visible tag color was pink. Growth rate of juvenile zebrafish was not affected by VIE tagging. Horizontal tagging is recommended in early stages of fish growth (1–2 months post hatch). VIE tags were retained for 1 year and tagging did not interfere with long-term growth and survival. There was no mortality associated with VIE tagging in rag1−/− zebrafish.

The VIE tagging system is highly suitable for small-sized zebrafish. When familiar with the procedure, 120 adult zebrafish can be tagged in one hour. It does not increase mortality in adult zebrafish or interfere with growth in juvenile or adult zebrafish.
Late-replicating CNVs as a source of new genes
Authors: Juan David , Rico Daniel , Marques-Bonet Tomas , Fernández-Capetillo Óscar , Valencia Alfonso
Published: November 2013

Asynchronous replication of the genome has been associated with different rates of point mutation and copy number variation (CNV) in human populations. Here, our aim was to investigate whether the bias in the generation of CNV that is associated with DNA replication timing might have conditioned the birth of new protein-coding genes during evolution. We show that genes that were duplicated during primate evolution are more commonly found among the human genes located in late-replicating CNV regions. We traced the relationship between replication timing and the evolutionary age of duplicated genes. Strikingly, we found that there is a significant enrichment of evolutionary younger duplicates in late-replicating regions of the human and mouse genome. Indeed, the presence of duplicates in late-replicating regions gradually decreases as the evolutionary time since duplication extends. Our results suggest that the accumulation of recent duplications in late-replicating CNV regions is an active process influencing genome evolution.
Post-transcriptional modifications modulate conformational dynamics in human U2–U6 snRNA complex
Authors: Karunatilaka Krishanthi S. , Rueda David
Published: November 2013

The spliceosome catalyzes precursor-mRNA splicing in all eukaryotes. It consists of over 100 proteins and five small nuclear RNAs (snRNAs), including U2 and U6 snRNAs, which are essential for catalysis. Human and yeast snRNAs share structural similarities despite the fact that human snRNAs contain numerous post-transcriptional modifications. Although functions for these modifications have been proposed, their exact roles are still not well understood. To help elucidate these roles in pre-mRNA splicing, we have used single-molecule fluorescence to characterize the effect of several post-transcriptional modifications in U2 snRNA on the conformation and dynamics of the U2–U6 complex in vitro. Consistent with yeast, the human U2–U6 complex reveals the presence of a magnesium-dependent dynamic equilibrium among three conformations. Interestingly, our data show that modifications in human U2 stem I modulate the dynamic equilibrium of the U2–U6 complex by stabilizing the four-helix structure. However, the small magnitude of this effect suggests that post-transcriptional modifications in human snRNAs may have a primary role in the mediation of specific RNA–protein interactions in vivo.
Syncretic narrative: Data in flux
Authors: Derr Diane
Published: November 2013

The syncretic narrative presents a unique opportunity for enabling a contrapuntal reading and analysis of information when produced through the networked model of communication. The various iterations of the syncretic narrative can be determined and outlined through a variety of diverse practices. This paper will address and propose an outline of attributes that would potentially demonstrate the construction of syncretic narrative within creative practice.
‘Heliosphere’: Intensities, the ionosphere and the solar wind
Authors: Grant Jane
Published: November 2013

This article will describe two forthcoming art/science projects, ‘Heliosphere’ (Grant, Kin, Matthias) and ‘The Sun Project’ (Grant, Kin, Matthias). Each project materializes data from solar flare activity by tracking the solar wind across the Earth.

Using information streamed from satellites orbiting the Earth’s atmosphere and from terrestrial detectors, the Sun’s activity will be visualized and sonified at sites across the Earth. The article also describes the research context undertaken in developing the work including solar physics, anthropology the history of science.
A video mnemonic: Consciousness research through creative practice
Authors: Payne Pam
Published: November 2013

This article describes an artwork in progress; a digital video of synchronized visual patterns based in part on rhythmic practices that are said to reliably lead to a shifted state of consciousness. The artwork is being developed to further understand the correlation of rhythm and consciousness. The investigation is based on a comparative study of the following practices: ‘The Art of Memory’ and Raymon Llull’s thirteenth-century diagrammatic mnemonics, the Lucid Dreaming exercises developed at Stanford University and the African Yoruba rhythms of ritualized possession. Throughout history, states of extreme lucidity, whether described as ‘ah-ha’ moments or life-transforming epiphanies, have been described with striking consistently and with such frequency that, rather than extraordinary, they seem to be fundamental to the human condition. The paradoxical state of lucid dreaming has been scientifically identified at Stanford University as a state of wakeful awareness that occurs during REM sleep, while dreaming. We might anticipate in the near future, the identification of a wakeful state of lucidity, a state as distinct from normal wakeful awareness as the state of dreaming. Those who have experienced altered states of consciousness can lend unique perspective and insight into the nature of consciousness. Analysis of practices that lead to such states add further insight. From running, to rhythmic breathing, to the circular movement of pilgrims at Mecca, to circular mosh pits, rhythmic activity is prevalent among practices that are said to lead to a shifted state of consciousness. The research suggests that in addition to rhythm itself, the relationship between rhythms is a significant factor corresponding to shifted states of consciousness. The digital video artwork discussed in this article might be thought of as a visualization of such rhythmic sequencing, and its development a creative method of inquiry.
Design as enclosure: Draft of a phenomenology of artifice
Authors: Turan Ahmet Zeki
Published: November 2013

This article drafts a phenomenology of artifice, an interpretation of Human Being and Human Practice, based on the extraordinary claim that design is not the initiator of change, creation and diversity, but it is the essential humanistic quality to compensate the irresistible precession, to regulate the inevitable transformation and divergence of the World. Inspired by the Sufism conception of Human Being, the argument here relies on the theory of a gradual disclosure from the kernel of Universal Man, the complete and Perfect Man of unity and continuity, down to the local man of differences, discontinuity and diversity. Sufism presents a phenomenology of appearing, describing a process of disclosure motivated by a mystical passion ‘to be known’, where in the beginning the Being is manifested on the Universal Man, that then degraded and diversified down to the local man, its Self, his or her community and his or her instruments. The article presents the Universal Man disclosing, and the local man enclosing in three grades that are aligned in conditional priority where the former enables the later one: (1) The Proximate Potentials, (2) The Mediate Linguals and (3) The Distant Actuals. The enclosed species of those layers are introduced as the primal categories of artefacts: (a) future contemplations out of the potentials, (b) present conversations out of the linguals and (c) past constructions out of the actuals. Towards the end, the article carries the discussion on how the Ur-Disclosure brings the inevitable conditional precedence of the future over the past; the future potentials come before the linguals of now and the past actuals follow after. So, it is claimed that anything new principally deviates from the future, from something already exists potentially on the proximate grade, where the Universal Man degrades into the unitary Selves. In the conclusion, it is proposed that design processes can not disclose, create and image anything but enclose, cover and regulate the genesis. The theory of gradual disclosure from the Universal Man to the local individual mainstreams the experience of ability presenting potential ability as a universal human experience that can be actualized by proper practice.
From mythology to psychology: Identifying archetypal symbols in movies
Authors: Chang Huang-Ming , Ivonin Leonid , Díaz Marta , Català Andreu , Chen Wei , Rauterberg Matthias
Published: November 2013

In this article, we introduce the theory of archetype, which explains the connection between ancient myths and the human mind. Based on the assumption that archetypes are in the deepest level of human mind, we propose that archetypal symbolism is a kind of knowledge that supports the cognitive process for creating subjective world-view towards the physical world we live in. According to archetypal symbolism, we conducted an empirical study to identify archetypal symbols in modern movies. A new collection of movie clips was developed to represent eight essential archetypes: anima, animus, mentor, mother, shadow, hero’s departure, hero’s initiation and hero’s return, which can be used in future studies on human emotion. In order to investigate the emotions towards these archetypal symbols, we provide suggestions from the psychological point of view. The present study demonstrates how to identify symbolic meanings in movies, and indicates a new direction for future studies in psychology.
Surgical Intervention for Embolization of Atrial Septal Defect Closure Devices: Case Report
Authors: Vural Hakan , Bozat Tahsin , Ay Derih , Çayir M. Çağdaş , Gücü Arif , Göncü Tuğrul
Published: November 2013

Atrial septal defect (ASD) closure using a percutaneous transcatheter device is used as an alternative to surgery. Various devices are increasingly used in clinical practice, and various types and models of septal occluder devices are available. The Amplatzer device (Amplatzer Medical, Golden Valley, MN, USA) is one with increasing popularity.We report a case of attempted percutaneous transcatheter closure of a large ASD in a 14-year-old girl, complicated by total device embolization to the right ventricle necessitating emergency surgery.
An Unusual Case of Candida Infection Producing a Fungus Ball in the Left Atrial Cavity
Authors: Saba Tonguç , Günday Murat , Çiftçi Özgür , Özülkü Mehmet , Erinanç Hilal , Turan Hale , Çoban Gökçen
Published: November 2013

We report the case of a 75-year-old male patient who was treated in our clinic for septicemia and subacute infective endocarditis caused by toxigenic Candida albicans. Transthoracic echocardiography revealed the presence of a thrombus in the left atrial cavity, and the diagnosis was confirmed by computerized tomography. The patient was operated on urgently. Histological examination of the embolic material removed from the left atrium showed the presence of yeast and hyphal forms of Candida albicans through periodic acid-Shiff stain. The patient was readmitted to the hospital on postoperative day 15, because of reembolism, and died later on. Here we present our approach to the diagnosis and treatment of this rare condition.
Intrapericardial Delivery of Amiodarone Rapidly Achieves Therapeutic Levels in the Atrium
Authors: Marcano Juan , Campos Karla , Rodriguez Victor , Handy Kelly , Brewer M. Alan , Cohn William E.
Published: November 2013

Background: Amiodarone is widely used worldwide as an important drug for managing supraventricular arrhythmias, regardless of its association with potentially severe side effects due to systemic toxicity. Amiodarone reduces the incidence of atrial fibrillation after cardiac surgery, but oral therapy requires a presurgery loading period, lasting from 1 to 4 weeks. In this study, we showed that it is possible to rapidly obtain therapeutic cardiac tissue levels of the drug by infusing aqueous amiodarone intrapericardially, without appreciable systemic exposure. We also examined the long-term histologic safety of intrapericardial infusion.Methods: In this observational study, 9 adult sheep, randomized into 3 groups of 3 animals each, were given low (2.5-mg/h), medium (10-mg/h), or high (50-mg/h) dosages of amiodarone by continuous infusion intrapericardially for 72 hours. An intrapericardial drain prevented tamponade from fluid build-up. Levels of amiodarone and its active metabolite, desethylamiodarone (DEA), were assessed both in plasma and in transmural biopsy specimens taken from the left atrial appendage and left and right ventricular myocardium. Cardiac, hepatic, and renal functions were also assessed. Humane euthanization was performed after 3 months, and cardiac and thoracic tissues were assessed for evidence of epicarditis, severe fibrotic changes, or other adverse effects potentially caused by the local amiodarone administration.Results: Pericardial infusion resulted in rapid uptake and high concentrations of amiodarone and DEA in the myocardial tissues, without an appreciable systemic presence of either drug. The highest and lowest levels of these agents were observed in the left atrium and left ventricle, respectively. Drug concentrations in all cardiac biopsy specimens were similar to, or higher than, those reportedly observed in patients taking long-term oral amiodarone. At 90 days, postmortem microscopic, biochemical, and hematologic evaluation of end-organ tissues from the 8 surviving sheep showed no adverse effects. Excessive inflammation or fibrotic changes were not observed in these 8 sheep. The ninth sheep died prematurely, and its death was deemed not to be related to this study.Conclusions: Short-term intrapericardial delivery of amiodarone is a safe method for rapidly obtaining therapeutic atrial-tissue drug levels. When begun perioperatively, this method may prevent postoperative atrial fibrillation similarly to oral or intravenous amiodarone therapy. However, we have shown that pericardial administration avoids systemic drug distribution and thus may greatly decrease the systemic complications resulting from this drug.
Genetics of Adverse Reactions to Haloperidol in a Mouse Diallel: A Drug–Placebo Experiment and Bayesian Causal Analysis
Authors: Crowley James J , Kim Yunjung , Lenarcic Alan B , Quackenbush Corey R , Barrick Cordelia J , Adkins Daniel E , Shaw Ginger S , Miller Darla R , de Villena Fernando Pardo-Manuel , Sullivan Patrick F , Valdar William
Published: November 2013

Haloperidol is an efficacious antipsychotic drug that has serious, unpredictable motor side effects that limit its utility and cause noncompliance in many patients. Using a drug–placebo diallel of the eight founder strains of the Collaborative Cross and their F1 hybrids, we characterized aggregate effects of genetics, sex, parent of origin, and their combinations on haloperidol response. Treating matched pairs of both sexes with drug or placebo, we measured changes in the following: open field activity, inclined screen rigidity, orofacial movements, prepulse inhibition of the acoustic startle response, plasma and brain drug level measurements, and body weight. To understand the genetic architecture of haloperidol response we introduce new statistical methodology linking heritable variation with causal effect of drug treatment. Our new estimators, “difference of models” and “multiple-impute matched pairs”, are motivated by the Neyman–Rubin potential outcomes framework and extend our existing Bayesian hierarchical model for the diallel (Lenarcic et al. 2012). Drug-induced rigidity after chronic treatment was affected by mainly additive genetics and parent-of-origin effects (accounting for 28% and 14.8% of the variance), with NZO/HILtJ and 129S1/SvlmJ contributions tending to increase this side effect. Locomotor activity after acute treatment, by contrast, was more affected by strain-specific inbreeding (12.8%). In addition to drug response phenotypes, we examined diallel effects on behavior before treatment and found not only effects of additive genetics (10.2–53.2%) but also strong effects of epistasis (10.64–25.2%). In particular: prepulse inhibition showed additivity and epistasis in about equal proportions (26.1% and 23.7%); there was evidence of nonreciprocal epistasis in pretreatment activity and rigidity; and we estimated a range of effects on body weight that replicate those found in our previous work. Our results provide the first quantitative description of the genetic architecture of haloperidol response in mice and indicate that additive, dominance-like inbreeding and parent-of-origin effects contribute strongly to treatment effect heterogeneity for this drug.
Indicadores de producción de los profesores de Educación Física y Didáctica de la Expresión Corporal en España en la Web of Science
Authors: Reverter Masià Joaquim , Hernández González Vicenç , Jové Deltell M. Carme , Legaz Arrese Alejandro
Published: November 2013

El índice de Hirsch es actualmente uno de los indicadores bibliométricos más utilizados para estimar los éxitos de trabajo de investigadores y predecir el impacto de producción en el futuro. Este trabajo lo utiliza como medida de productividad y calidad científica de las citas totales, número de artículos y Índice h de los profesores españoles de las ciencias del deporte. También se analiza, número de autores por artículo, revistas en que publican, universidad que más artículos publica y profesores que más producen en Web of Science. Los resultados revelan que el Índice h correlaciona ampliamente citas y número de artículos. Las distribuciones por áreas, indican que el área de Educación Física tiene un Índice h medio de 2,65 y el área de Expresión Corporal 1,61. La proporción media de artículos por profesor, oscila entre 4 y 7. La media de autores firmantes oscila entre 4 y 6. La revista en que más publican los profesores de Expresión Corporal es Revista de Psicología del Deporte y en Educación Física es Journal of Strength and Conditioning Research. Finalmente, se plantean que implicaciones tienen estos resultados y el uso que de los mismos se puede dar en la toma de decisiones académicas y de investigación.
Mineração de textos biomédicos: uma revisão bibliométrica
Authors: Woszezenki Cristiane Raquel , Gonçalves Alexandre Leopoldo
Published: November 2013

A mineração de textos vem sendo, cada vez mais, empregada para automatizar o processo de extração de informações importantes, contidas em textos biomédicos, possibilitando que os pesquisadores fiquem a par do desenvolvimento da biomedicina. Considerando a importância deste campo de pesquisa, este artigo apresenta um mapeamento das publicações científicas sobre mineração de textos biomédicos e discute as principais tarefas desse campo de pesquisa, as quais os pesquisadores têm dedicado maior atenção. Para isso, foi utilizada a bibliometria, uma técnica que permite analisar o desenvolvimento de um campo da ciência, visando identificar suas características. O mapeamento apresentado promove o conhecimento sobre o histórico e o estado atual do campo de pesquisa e disponibiliza insumos, que permitem enriquecer a discussão sobre os possíveis rumos que as pesquisas, na área, têm tomado e as prováveis tendências científicas para os pesquisadores e interessados no tema.
Correlações entre a contagem de citações de pesquisadores brasileiros, usando o Web of Science, Scopus e Scholar
Authors: Vieira Paula Vanessa Medeiros , Wainer Jacques
Published: November 2013

Este trabalho estuda a correlação entre medidas bibliométricas (índice h e quantidade total de citações), obtidas através de diferentes serviços de contagem de citações (Web of Science, Scholar e Scopus). Calculamos essas medidas para diversos pesquisadores do CNPq. Então, obtivemos a correlação dos resultados obtidos para cada medida, entre cada par de serviços. As correlações foram calculadas para cada uma das subáreas divididas, nas seguintes áreas: Ciências Biológicas, Ciências Exatas, Ciências Humanas, Ciências da Saúde, Ciências Sociais Aplicadas, Engenharia e Letras, Linguística e Artes . Discutimos o significado das correlações obtidas.
Comparativo entre banco relacional e base textual: CDS/ISIS
Authors: Melo Daniel Augusto de , Palhares Márcia Maria , Palhares Mônica Geralda
Published: November 2013

Apresenta uma nova forma de armazenamento para dados bibliográficos de uma rede de bibliotecas. Mostra um modelo de banco de dados e ferramentas que possibilitam a migração dos dados da Base Textual CDS/ISIS para o Banco Relacional Oracle. Informa, ainda, que, com a utilização desse projeto, será possível obter a mesma mobilidade para diferentes aplicações, com a tecnologia utilizada hoje, agregada às garantias de um Sistema Gerenciador de Banco de Dados.
Impactos dos nomes nas propriedades de redes sociais: um estudo em rede de coautoria sobre sustentabilidade
Authors: Barbastefano Rafael Garcia , Souza Cristina , Costa Juliana de Sousa , Teixeira Patrícia Mattos
Published: November 2013

A identificação correta dos autores é fator crítico em estudos de Análise de Redes Sociais (ARS) que envolvem redes de coautoria. O objetivo do trabalho é apresentar as diferenças de propriedades entre três redes de coautoria geradas com formas distintas de considerar o nome dos autores. Foi adotado o método bibliométrico. As redes foram construídas com base em 28.916 artigos sobre sustentabilidade, indexados no ISI/Web of Science, fazendo uso do software Pajek. Na análise, foram comparadas as seguintes propriedades: densidade, grau médio, componente gigante, distribuição dos graus, distância média, diâmetro da rede e coeficiente de clusterização de Watts-Strogatz. Os resultados indicaram grandes diferenças entre as redes, sugerindo que estudos de coautoria, fazendo uso de ARS, podem ter resultados comprometidos, caso não haja o tratamento adequado dos nomes dos autores. Diante do crescimento das aplicações de ARS, faz-se necessário o desenvolvimento de estudos e ferramentas voltados para mitigar a ocorrência desses erros.
Gestão documental da informação jurídica
Authors: Miranda Ana Cláudia Carvalho de , D'Amore Ticiano Maciel , Pinto Virginia Bentes
Published: November 2013

Este artigo apresenta uma nova performance da gestão documental, voltada para o desenvolvimento das coleções no âmbito da informação jurídica, estabelecendo critérios de qualidade para os processos de seleção, aquisição e avaliação das informações. Para esse propósito, é feita uma avaliação das várias dimensões que permeiam a gestão documental da informação jurídica como um todo. A rapidez com que a informação jurídica se inova torna a literatura (ainda que recente) ultrapassada e obsoleta, ocasionando, assim, uma maior dificuldade das bibliotecas permanecerem com suas publicações sempre atualizadas. Por isso, é preciso que sejam elaborados mecanismos de controle e que seja efetuado um bom desenvolvimento dos serviços prestados pelas mesmas. Esses mecanismos são criados por meio da política de desenvolvimento de coleções, pois, quando bem fundamentada, assegura o bibliotecário na tomada de decisões, tanto em relação ao processo de seleção, aquisição e descarte do acervo, como na sustentação da qualidade na atualização da coleção. O processo de desenvolvimento da coleção é visto sob o viés da abordagem sistêmica das organizações.
Prática e coeficiente na produção de documentos: uma ação sustentável
Authors: Moreira Breno Rolindo Lara , Oliveira Adriana Fileto Couto e Silva de , Silva Janete Fernandes
Published: November 2013

Apesar das questões relativas à sustentabilidade e ecoeficiência estarem na ordem do dia das organizações, muitos gestores enfrentam dificuldades ao adotarem práticas ecoeficientes, por conta do descrédito de colaboradores. Este artigo realizou um estudo empírico pioneiro e comprovou que a Ecofont contribui significativamente para a economia de recursos (naturais e materiais), além de reduzir a emissão de dióxido de carbono. Optou-se pelo estudo de caso na Câmara Municipal de Belo Horizonte, porque a organização é responsável por um volume significativo de impressão de documentos. Foram utilizados dados primários, cálculos, testes e softwares, como Word 2003 e APFILL.
A internacionalização da Biblioteca Nacional: identificação das ações nos relatórios institucionais (1905-1915)
Authors: Juvêncio Carlos Henrique , Rodrigues Georgete Medleg
Published: November 2013

No início do século XX, no bojo das ações de modernização do próprio Estado, a Biblioteca Nacional brasileira manteve um profícuo intercâmbio com várias instituições internacionais. Por meio das informações contidas em seus relatórios institucionais, buscou-se, neste artigo, evidenciar as ações empreendidas pela Biblioteca Nacional na busca do que denominamos sua "internacionalização", no período de 1905 a 1915. Para tanto, utilizamos, como procedimento metodológico, o levantamento das seções dos relatórios, selecionando aquelas cujos títulos referiam-se a essas ações de internacionalização. Em seguida, procedemos à análise de cada seção, extraindo as informações que corroboravam com os objetivos da pesquisa. A título de conclusão ainda parcial, constatou-se que a Biblioteca Nacional buscou, de fato, contatos com instituições estrangeiras, visando à modernização de seus métodos e técnicas de tratamento de seu acervo, bem como a recuperação de parte da história do Brasil nos arquivos do exterior, além de realizar ações de intercâmbio com diversas instituições.
Configuração e recuperação da informação em documentos de ciência e tecnologia: estudo tipológico em arquivo pessoal no arquivo pessoal do físico Bernhard Gross
Authors: Silva Maria Celina Soares Mello e
Published: November 2013

O artigo trata do projeto de pesquisa, em andamento, sobre levantamento tipológico em arquivos pessoais de cientistas, com o objetivo de conhecer os documentos e identificar as atividades que o produziram, visando à elaboração de um glossário. O tipo documental enriquece a descrição e a recuperação da informação e leva ao conhecimento do documento, de acordo com a atividade que o produziu. Alguns estudos tipológicos, realizados em arquivos institucionais e pessoais, foram utilizados como referencial, bem como trabalhos acadêmicos sobre o tema. O artigo apresenta alguns tipos documentais encontrados no arquivo pessoal do físico Bernhard Gross, como exemplo do levantamento, e consideraçoes sobre glossário e a recuperação da informação.
Planejamento, desenvolvimento e implantação do Programa Pró-Multiplicar da CAPES na UFMG: metodologia aplicada
Authors: Cendón Beatriz Valadares , Costa Maria Elizabeth de Oliveira
Published: November 2013

Em 2010, a Universidade Federal de Minas Gerais (UFMG) aderiu ao programa Pró-Multiplicar da CAPES. O Programa visa a capacitar alunos bolsistas de doutorado/ mestrado da CAPES em instituições credenciadas pelo Portal, para atuarem como monitores e multiplicadores na divulgação e instrução sobre o uso do Portal de Periódicos, junto aos seus colegas de graduação e pós-graduação. Após o encerramento e avaliação das atividades do Pró-Multiplicar na UFMG, foram treinados, pelos instrutores da CAPES e das editoras presentes no Portal, 48 alunos multiplicadores e 17 bibliotecários, que deram suporte ao Programa. Por meio de uma metodologia criada e aplicada pela Coordenação do Programa na instituição, 43 alunos multiplicadores, por sua vez, realizaram 72 treinamentos para 293 alunos de graduação e pós-graduação. Considera-se, assim, ter alcançado, com sucesso, os objetivos pretendidos. Este artigo visa a compartilhar a metodologia desenvolvida, a experiência obtida na implantação do Programa na instituição e os demais resultados preliminares obtidos nos treinamento do programa Pró-Multiplicar da CAPES na UFMG. Com base nesta experiência, o artigo também oferece sugestões para o fortalecimento do Programa Pró-Multiplicar.
Estado, sociedade e educação superior no Brasil Império: o passado presente
Authors: Marques Waldemar
Published: November 2013

Constituem objeto de análise deste texto as relações entre estado, sociedade e educação superior no Brasil Império. Destaca o quanto a formação social escravocrata e a constituição de um estado oligárquico inviabilizaram a criação da universidade no país, limitando a educação superior a cursos de formação profissional, cujas características resistiram às mudanças ocorridas no país, adentraram o século XX, persistindo suas marcas até o presente.