bluuebunny/crossref_metadata_2025 huggingface dataset:
Text-Centric Multimodal Contrastive Learning for Sentiment Analysis
Authors: Peng Heng , Gu Xue , Li Jian , Wang Zhaodan , Xu Hao
Published: March 2024

Multimodal sentiment analysis aims to acquire and integrate sentimental cues from different modalities to identify the sentiment expressed in multimodal data. Despite the widespread adoption of pre-trained language models in recent years to enhance model performance, current research in multimodal sentiment analysis still faces several challenges. Firstly, although pre-trained language models have significantly elevated the density and quality of text features, the present models adhere to a balanced design strategy that lacks a concentrated focus on textual content. Secondly, prevalent feature fusion methods often hinge on spatial consistency assumptions, neglecting essential information about modality interactions and sample relationships within the feature space. In order to surmount these challenges, we propose a text-centric multimodal contrastive learning framework (TCMCL). This framework centers around text and augments text features separately from audio and visual perspectives. In order to effectively learn feature space information from different cross-modal augmented text features, we devised two contrastive learning tasks based on instance prediction and sentiment polarity; this promotes implicit multimodal fusion and obtains more abstract and stable sentiment representations. Our model demonstrates performance that surpasses the current state-of-the-art methods on both the CMU-MOSI and CMU-MOSEI datasets.
Energy Efficient Graph-Based Hybrid Learning for Speech Emotion Recognition on Humanoid Robot
Authors: Wu Haowen , Xu Hanyue , Seng Kah Phooi , Chen Jieli , Ang Li Minn
Published: March 2024

This paper presents a novel deep graph-based learning technique for speech emotion recognition which has been specifically tailored for energy efficient deployment within humanoid robots. Our methodology represents a fusion of scalable graph representations, rooted in the foundational principles of graph signal processing theories. By delving into the utilization of cycle or line graphs as fundamental constituents shaping a robust Graph Convolution Network (GCN)-based architecture, we propose an approach which allows the capture of relationships between speech signals to decode intricate emotional patterns and responses. Our methodology is validated and benchmarked against established databases such as IEMOCAP and MSP-IMPROV. Our model outperforms standard GCNs and prevalent deep graph architectures, demonstrating performance levels that align with state-of-the-art methodologies. Notably, our model achieves this feat while significantly reducing the number of learnable parameters, thereby increasing computational efficiency and bolstering its suitability for resource-constrained environments. This proposed energy-efficient graph-based hybrid learning methodology is applied towards multimodal emotion recognition within humanoid robots. Its capacity to deliver competitive performance while streamlining computational complexity and energy efficiency represents a novel approach in evolving emotion recognition systems, catering to diverse real-world applications where precision in emotion recognition within humanoid robots stands as a pivotal requisite.
An Ultra-Low-Power 65 nm Single-Tank 24.5-to-29.1 GHz Gm-Enhanced CMOS LC VCO Achieving 195.2 dBc/Hz FoM at 1 MHz
Authors: Kurtoglu Abdullah , Shirazi Amir H. M. , Mirabbasi Shahriar , Miri Lavasani Hossein
Published: March 2024

A low-power single-core 24.5-to-29.1 GHz CMOS LC voltage-controlled oscillator (VCO) is presented. The proposed VCO uses an innovative differential cross-coupled architecture in which an additional pair is connected to the main pair to increase the effective transconductance, resulting in lower power consumption and reduced phase noise (PN). The proposed VCO is fabricated in a 1P9M standard CMOS process and sustains oscillation at 29.14 GHz with power consumption as low as 455 μW (650 μA from a 0.7 V supply), which is ~20% lower than a conventional CMOS LC VCO without Gm-enhanced differential pairs built through the same process (700 μA from 0.8 V supply). When consuming 880 μW (1.1 mA from 0.8 V), the proposed VCO exhibits a tuning range of 4.6 GHz (from 24.5 GHz to 29.1 GHz). Moreover, it exhibits a measured phase noise (PN) better than −106.5 dBc/Hz @ 1 MHz and −132.0 dBc/Hz @ 10 MHz, with figure-of-merit (FoM) results of 195.2 dBc/Hz and 200.3 dBc/Hz, respectively.
Experimental Investigation of Injection and Production Cycles for Limestone Reservoirs via Micro-CT: Implications for Underground Gas Storage
Authors: Wang Mengyu , Wang Guanqun , Hu Yong , Zhou Yuan , Li Wei , Han Dan , Zhao Zihan , Wang Xia , Li Longxin , Long Wei
Published: March 2024

Global demand for underground gas storage (UGS) is steadily increasing, with the limestone-based UGS system situated in the Sichuan Basin of China gathering considerable interest in recent years. However, studies focusing on the fundamental mechanisms of the injection-production process in these systems are limited. Moreover, existing studies utilizing physical experimental methods frequently fall short in effectively visualizing micro-flow or incorporating real core samples from the reservoir. To address these gaps, we performed a coreflood experiment, integrating micro-Computed Tomography (CT) scanning to investigate mechanisms of fluid flow and storage capacity during the injection and production cycles in limestone reservoirs. Our approach involved utilizing core plugs with artificially engraved fracture-vuggy structures, which mimic the characteristics of the reservoir. Micro-CT scans were performed to visualize the microscopic changes in fractured-vuggy structures and the distribution of irreducible water during each cycle. This study reveals that increased cycles correspondingly affect gas storage capacity, particularly by expanding it in relative larger vuggy structures while reducing it in finer fissure network structures. The amount of irreducible water decreases after injection-production cycles, likely being expelled alongside the extracted dry gas. This plays a critical role in expanding the storage capacity in larger vuggy systems. Conversely, there is a decrease in storage capacity within fissure network systems, as the irreducible water is replaced by gas. This leads to a reduction in the opening force of the fine conduit. The dense matrix has a very limited effect on the flow mechanism and its influence on storage capacity. Overall, these findings offer practical insights for optimizing injection and production strategies in limestone UGS systems within the Sichuan Basin, contributing to a deeper understanding and efficient utilization of this vital infrastructure.
Optimization of Bacterial Cellulose Production by Komagataeibacter rhaeticus K23
Authors: Uğurel Ceyda , Öğüt Hamdi
Published: March 2024

The use of bacterial cellulose (BC), having high purity, a high degree of crystallinity, water-holding capacity, tensile strength and adaptability on a broad scale is limited because of the low yield. In this study, the optimal conditions for bio-cellulose production by Komagataeibacter rhaeticus K23 were investigated. Optimal values for temperature, pH, inoculum concentration and incubation time were determined via Taguchi design. The maximum BC production, 9.1 ± 0.66 g·L−1 (dry weight), was obtained from 32 °C, pH 5.5, 8 log CFU·mL−1 and 14 days of incubation. The inoculum concentration was the most significant factor affecting BC yield. A value of 8 log CFU·mL−1 and 14 days of incubation led to significantly higher levels of BC yield than other concentrations (8.5, 9, 9.5, 10 and 10.5 log CFU·mL−1) (p < 0.002) and days (15, 16, 17, 21 and 28) (p < 0.001). The studied features, namely absorption peaks (Fourier transform infrared spectroscopy), pattern and the crystallinity index (X-ray diffraction analysis) of the BC obtained in this study were all in parallel with the characteristics of cellulose I. The study demonstrates that optimized parameters were effective in producing BC with high water-holding capacity, tensile strength, elongation and Young’s modulus (mechanical tests) by K. rhaeticus K23.
Prevalence and Influence of Gout in Patients with Advanced Chronic Kidney Disease: Findings of a Large Retrospective Chart Review
Authors: Stern Leonard , Johnson Richard J. , Shakouri Payam , Athavale Amod , Padnick-Silver Lissa , LaMoreaux Brian , Marder Brad A. , Mandayam Sreedhar
Published: March 2024

Gout patients have higher mortality, heavier comorbidity burden, and lower quality of life than non-gout patients, but information is sparse on how gout affects advanced CKD patients. This study examined the prevalence and potential health impacts in stage 3–5 CKD patients. Gout was defined as being listed as a comorbidity, ULT use, and/or reported gout symptoms (tophi, >1 flare). Uncontrolled gout was defined as hyperuricemia (serum urate >6 mg/dL) with tophi, ≥2 gout flares/year, or ≥1 swollen/tender joint. This study included 746 patients (55% men, age: 56.2 ± 18.3 years, CKD-duration: 4.0 ± 4.8 years, eGFR: 32.2 ± 15.5 mL/min/1.73 m2), of which 23% met the gout criteria. Prevalence was highest in patients with stage 3b and 4 CKD. Gout patients had a significantly higher prevalence of cardiovascular comorbidities, CKD-mineral bone disorder, and back pain than non-gout patients. Uncontrolled gout patients had more hypertension, joint issues, chronic pain, febuxostat use, and colchicine use than controlled patients. Compared to those without gout, gout patients had higher rates of cardiovascular and bone diseases, with uncontrolled patients having an even higher burden. In conclusion, these data suggest that identifying and monitoring gout in CKD patients provides health benefits. However, more than one-third of gout patients did not have a formal gout diagnosis in their medical record.
Identification and Functional Analysis of 1-Deoxy-D-xylulose-5-phosphate Synthase Gene in Tomatoes (Solanum lycopersicum)
Authors: Ge Haicui , Lu Junyang , Han Mingxuan , Lu Linye , Tian Jun , Zheng Hongzhe , Liu Shuping , Zhong Fenglin , Hou Maomao
Published: March 2024

1-deoxy-D-xylulose-5-phosphate synthase (DXS) is a rate-limiting enzyme in terpene synthesis that can affect the accumulation of secondary metabolites in plants. In this study, three DXS gene family members were identified in the tomato genome-wide database. Using bioinformatics methods, we analyzed the gene structure, evolutionary affinities, and cis-acting elements of the SlDXS gene family members. Promoters of SlDXS genes contain plant hormone-responsive elements such as the CGTCA-motif, TGACG-motif, ABRE, TCA-element, TGA-element, ERE, CAT-box, and AACA-motif, which suggested that the SlDXS gene family may play an important role in hormone response. The RT-qPCR analysis showed that the tomato DXS2 gene was able to respond upon exposure to methyl jasmonate (MeJA). The construction of a virus-induced gene silencing (VIGS) vector for the SlDXS gene showed that the SlDXS2 gene was also able to respond to MeJA in silenced plants, but the induction level was lower relative to that of wild-type plants. The SlDXS1 gene is associated with the synthesis of photosynthetic pigments. This study provides a reference for the further elucidation of the DXS gene’s biological function in the terpenoid synthesis pathway in tomatoes.
Role of Sensory Nerves in Pulmonary Fibrosis
Authors: Norton Charles E.
Published: March 2024

Pulmonary fibrosis results from the deposition and proliferation of extracellular matrix components in the lungs. Despite being an airway disorder, pulmonary fibrosis also has notable effects on the pulmonary vasculature, with the development and severity of pulmonary hypertension tied closely to patient mortality. Furthermore, the anatomical proximity of blood vessels, the alveolar epithelium, lymphatic tissue, and airway spaces highlights the need to identify shared pathogenic mechanisms and pleiotropic signaling across various cell types. Sensory nerves and their transmitters have a variety of effects on the various cell types within the lungs; however, their effects on many cell types and functions during pulmonary fibrosis have not yet been investigated. This review highlights the importance of gaining a new understanding of sensory nerve function in the context of pulmonary fibrosis as a potential tool to limit airway and vascular dysfunction.
Postponement of the Newborn Hearing Screening during the COVID-19 Pandemic; Parental Experiences and Worries
Authors: van der Zee Rosanne B. , Peet Sanne L. , Uilenburg Noëlle N. , van Bakel Hedwig J. A. , Dirks Evelien
Published: March 2024

Early identification of hearing loss through newborn hearing screening followed by an early start of intervention has proven to be effective in promoting speech and language development in children with hearing loss. During the COVID-19 pandemic, newborn hearing screening was postponed for a group of newborns in the Netherlands. Therefore, meeting the guidelines for early identification was at risk. In this study, we examine parental attitudes, beliefs, and experiences concerning the hearing screening during the COVID-19 pandemic. Our results indicated that parents (n = 1053) were very positive about newborn hearing screening and their experiences with the screening, even during the COVID-19 pandemic. Parents’ beliefs on the information provision around newborn hearing screening were more inconsistent. The results showed that parents with a postponed hearing screening felt less informed about the hearing screening than parents without a postponed screening. Furthermore, child and family characteristics affected how parents experienced newborn hearing screening. Parents with a premature child were more worried about the hearing abilities of their child before the screening took place. The results also indicate that deafness in the family might lead to parental worries around newborn hearing screening.
Advancing Video Data Privacy Preservation in IoT Networks through Video Blockchain
Authors: Moolikagedara Kasun , Nguyen Minh , Yan Weiqi , Li Xuejun
Published: March 2024

In the digital age, where the Internet of Things (IoT) permeates every facet of our lives, the safeguarding of data privacy, especially video data, emerges as a paramount concern. The ubiquity of IoT devices, capable of capturing and disseminating vast quantities of video data, introduces unprecedented challenges in ensuring the privacy and security of such information. This article explores the crucial intersection of video data privacy and blockchain technology within IoT networks. It aims to uncover and articulate the unique challenges video data encounter in the IoT ecosystem, such as susceptibility to unauthorized access and the difficulty in ensuring data integrity and confidentiality. By conducting a thorough literature review, this study not only illuminates the intricate privacy challenges inherent in IoT environments but also showcases the immutable, decentralized nature of blockchain as a potent solution. We systematically explore how blockchain-based methods can be pragmatically implemented to fortify video data privacy, scrutinizing the efficacy of these approaches in the IoT context. Through critical assessment, the paper delineates the strengths and limitations of video blockchain solutions, underscoring the transformative potential of blockchain technology as a cornerstone for enhancing data privacy in IoT networks. Conclusively, this work advocates for blockchain as an indispensable tool in the advancement of data privacy measures for video content, thereby reinforcing trust and security in the increasingly connected fabric of our digital world. As IoT applications burgeon, the fusion of blockchain technology with IoT infrastructures promises a robust framework for protecting sensitive video data, heralding a future of enhanced trust and security in our interconnected ecosystem.
Pre-Therapeutic Assessment of Older People in Sub-Saharan Africa: Introduction to the Comprehensive Geriatric Assessment
Authors: Ntsama Essomba Marie-Josiane , Esson Mapoko Berthe Sabine , Metogo Mbengono Junette Arlette , Simo-Tabue Nadine , Kengne Andre Pascal , Choukem Simeon Pierre , Sobngwi Eugène , Ze Minkande Jacqueline , Tabue Teguo Maturin
Published: March 2024

Objectives: With the ongoing epidemiological transition in sub-Saharan Africa (SSA), conditions that require invasive treatment (surgery, cancer, and anaesthesia, etc.) will become increasingly common. Comprehensive geriatric assessment (CGA) is a multidisciplinary diagnostic process aimed at identifying older people at risk of negative outcomes. It is important to know whether this approach integrates care management strategies for older people in a context where health services for older people are scarce, and staff members have little training in geriatrics. The current work is a situational analysis on the use of CGA on invasive care (cancer, surgery, etc.) among older people in SSA. Methods: We searched PubMed-MEDLINE and other sources for studies reporting on CGA and conditions requiring invasive treatment in older patients in SSA. Results/Conclusions: We found no study that had comprehensively examined CGA and invasive care in SSA. There is, however, evidence that the offer of invasive care to older people has improved in SSA. Further research is needed to explore the applicability of CGA in SSA. Similarly, more investigations are needed on the role of CGA in the care trajectories of older people in SSA, in terms of outcomes and affordability.
Navigating the Landscape of Cardiovascular Risk Scores: A Comparative Analysis of Eight Risk Prediction Models in a High-Risk Cohort in Lithuania
Authors: Navickas Petras , Lukavičiūtė Laura , Glaveckaitė Sigita , Baranauskas Arvydas , Šatrauskienė Agnė , Badarienė Jolita , Laucevičius Aleksandras
Published: March 2024

Background: Numerous cardiovascular risk prediction models (RPM) have been developed, however, agreement studies between these models are scarce. We aimed to assess the inter-model agreement between eight RPMs: assessing cardiovascular risk using SIGN, the Australian CVD risk score (AusCVDRisk), the Framingham Risk Score for Hard Coronary Heart Disease, the Multi-Ethnic Study of Atherosclerosis risk score, the Pooled Cohort Equation (PCE), the QRISK3 cardiovascular risk calculator, the Reynolds Risk Score, and Systematic Coronary Risk Evaluation-2 (SCORE2). Methods: A cross-sectional study was conducted on 11,174 40–65-year-old individuals with diagnosed metabolic syndrome from a single tertiary university hospital in Lithuania. Cardiovascular risk was calculated using the eight RPMs, and the results were categorized into high, intermediate, and low-risk groups. Inter-model agreement was quantified using Cohen’s Kappa coefficients. Results: The study revealed significant heterogeneity in risk categorizations with only 1.49% of cases where all models agree on the risk category. SCORE2 predominantly categorized participants as high-risk (67.39%), while the PCE identified the majority as low-risk (62.03%). Cohen’s Kappa coefficients ranged from −0.09 to 0.64, indicating varying degrees of inter-model agreement. Conclusions: The choice of RPM can substantially influence clinical decision-making and patient management. The PCE and AusCVDRisk models exhibited the highest degree of agreement while the SCORE2 model consistently exhibited low agreement with other models.
Aromatase Inhibitors and Plasma Lipid Changes in Postmenopausal Women with Breast Cancer: A Systematic Review and Meta-Analysis
Authors: Bérczi Bálint , Farkas Nelli , Hegyi Péter , Tóth Barbara , Csupor Dezső , Németh Balázs , Lukács Anita , Czumbel László Márk , Kerémi Beáta , Kiss István , Szabó Andrea , Varga Gábor , Gerber Gábor , Gyöngyi Zoltán
Published: March 2024

Background: Women are typically diagnosed with estrogen receptor-positive breast cancer around the postmenopausal period when declining estrogen levels initiate changes in lipid profiles. Aromatase inhibitors (AI) are used to prevent the progression of cancer; however, a further reduction in estrogen levels may have detrimental effects on lipid levels, which was our working hypothesis. Methods: Our meta-analysis was conducted on the lipid profiles of postmenopausal breast cancer patients at baseline and at different treatment time points. Results: We identified 15 studies, including 1708 patients. Studies using anastrozole (ANA), exemestane (EXE), letrozole (LET), and tamoxifen (TMX) were involved. Subgroup analyses revealed that 3- and 12-month administrations of LET and EXE lead to negative changes in lipid profiles that tend to alter the lipid profile undesirably, unlike ANA and TMX. Conclusions: Our results suggest that, despite statistically significant results, EXE and LET may not be sufficient to cause severe dyslipidemia in patients without cardiovascular comorbidities according to the AHA/ACC Guideline on the Management of Blood Cholesterol. However, the results may raise the question of monitoring the effects of AIs in patients, especially those with pre-existing cardiovascular risk factors such as dyslipidemia.
The Quality of Life in Patients with Spinal Cord Injury: Assessment and Rehabilitation
Authors: Cardile Davide , Calderone Andrea , De Luca Rosaria , Corallo Francesco , Quartarone Angelo , Calabrò Rocco Salvatore
Published: March 2024

Background and Objectives: Spinal Cord Injury (SCI) develops when the spinal cord is damaged and leads to partial or complete loss of motor and/or sensory function, usually below the level of injury. Medical advances in the last few decades have enabled SCI patients to survive after their initial injury and extend their life expectancy. As a result, the need for outcome measures to assess health and Quality of Life (QoL) after rehabilitation is increasing. All QoL assessment measures include implicit or explicit reactions and evaluations of a person’s life characteristics. This review aims to investigate QoL and its assessment in patients with SCI and how the instruments that are used may influence rehabilitation. Materials and Methods: Studies were identified from an online search of PubMed, Cochrane Library, and Scopus databases. Studies published between 2013 and 2023 were selected. This review has been registered on OSF (n) 892NY. Results: We found that different psychological and physical aspects can positively or negatively influence the QoL of SCI patients, and the measurement of this aspect, despite the number of tools, is limited due to the lack of a universal definition of this theme and the greater prevalence of quantitative rather than qualitative tools. Conclusions: This review has demonstrated that clinicians and psychologists involved in SCI rehabilitation should consider tools that use high-quality standardized outcome measures to detect and compare potential differences and outcomes of interventions related to HRQoL and their relationship with the personality and functional status of the patient.
Investigation of Risk Factors Predicting Cataract Surgery Complications in Patients with Pseudoexfoliation Syndrome: A Systematic Review
Authors: Preoteasa Laura Denisa , Baltă George , Baltă Florian N.
Published: March 2024

(1) Background: The present review aims to identify risk factors with predictive value for differentiating between pseudoexfoliation patients at risk of developing intra- or postoperative complications and those without operative risk during cataract surgery. (2) Methods: The review protocol was registered at PROSPERO, registration no. CRD42023417721. The following databases were searched for studies between 2000 and 2023: PubMed/Medline, Scopus, Springer, Science Direct, Web of Science, Cochrane Database of Systematic Reviews, TRIP database, LILACS, Clinical Trials, and reference lists of articles. We included analytical studies of any design examining cataract surgery complications in pseudoexfoliation patients across two population groups, one who underwent uneventful cataract surgery and the other who experienced intra- or postoperative complications. The paper will follow PRISMA 2020 criteria for reporting. Effect measure was assessed using odds ratios (ORs) and corresponding 95% confidence interval (CI) for qualitative variables and means with their respective standard deviation (SD) for quantitative variables. The risk of bias was assessed using the method presented in the Cochrane Handbook for Systematic Reviews. The GRADE scale was used for quality of evidence and certainty. (3) Results: The initial search of published and gray literature databases retrieved 1435 articles, six of which were included in this report. A total of 156 intra- or postoperative incidents were reported in 999 eyes with pseudoexfoliation. The identified predictive factors were a shallow anterior chamber, cataract grade, neutrophil-to-lymphocyte ratio, preoperative intraocular pressure, and symmetry of the exfoliation material. Limitations include heterogeneity of data and limited number of studies identified in our search. (4) Conclusions: These findings suggest the potential to refine risk stratification protocols in clinical settings and assist surgeons in personalized decision-making among individuals with pseudoexfoliation syndrome.
Static and Dynamic Mechanical Behavior of Carbon Fiber Reinforced Plastic (CFRP) Single-Lap Shear Joints Joule-Bonded with Conductive Epoxy Nanocomposites
Authors: Huang Yuheng , Kinloch Ian A. , Vallés Cristina
Published: March 2024

The potential of electrically conductive graphene nanoplatelets (GNPs)/epoxy, multi-walled carbon nanotubes (MWNCTs)/epoxy and hybrid GNPs-MWCNTs/epoxy nanocomposites as adhesives for out-of-autoclave (OoA) and in-the-field CFRP repair via Joule heat curing was investigated. Scanning electron microscopy revealed a good dispersion of the nanoparticles in the matrix in all the nanocomposite adhesives above their percolation thresholds, which led to a homogeneous distribution of the heat generated during Joule CFRP repair. The joints bonded with neat epoxy and the nanocomposites showed similar lap shear strengths, with the addition of nanoparticles enhancing the fatigue performance of the adhesively bonded joints relative to when neat epoxy was used as an adhesive and oven-cured. The interfacial and cohesive failure mechanisms were found to coexist in all the cases, with an increasing dominance of the cohesive when nanofillers were embedded into the adhesive. No effect of the specific type of nanofiller incorporated into the epoxy as the conductive component was observed on the mechanical performance of the bonded joints, with the adhesives containing MWCNTs showing similar results to those filled with GNPs at considerably lower loadings due to their lower percolation thresholds. The independence of the properties regardless of the curing method highlights the promise of these Joule-cured adhesives for industrial applications.
Clinical Variables and Peripheral Biomarkers Associated with Substance-Induced Psychotic Disorder: Differences Related to Alcohol, Cannabis, and Psychostimulant Abuse
Authors: Di Paolo Martina , Calabrese Antonia , Nosari Guido , Ciappolino Valentina , Cirella Luisa , Caldiroli Alice , Capuzzi Enrico , Clerici Massimo , Buoli Massimiliano
Published: March 2024

Background: The present retrospective observational study aims to identify differences in clinical features and peripheral biomarkers among patients affected by substance-induced psychotic disorder (SIPD) according to the primary substance of abuse. Methods: A sample of 218 patients was divided into three groups according to the type of consumed substance: alcohol, cannabis, and psychostimulants. The three groups were compared using one-way analyses of variance (ANOVAs) for continuous variables and χ2 tests for qualitative variables. After excluding the alcohol-induced psychotic disorder group, the same analyses were repeated. The statistically significant variables from these subsequent analyses were included in a binary logistic regression model to confirm their reliability as predictors of cannabis- or psychostimulant-induced psychotic disorder. Results: Psychotic cannabis abusers were younger (p < 0.01), with illness onset at an earlier age (p < 0.01). Alcohol consumers presented a longer duration of illness (p < 0.01), more frequent previous hospitalizations (p = 0.04) and medical comorbidities (p < 0.01), and higher mean Modified Sad Persons Scale scores (p < 0.01). Finally, psychostimulant abusers had a higher frequency of lifetime history of poly-substance use disorders (p < 0.01). A binary logistic regression analysis revealed that higher mean Brief Psychiatric Rating Scale scores (p < 0.01) and higher sodium (p = 0.012) and hemoglobin (p = 0.040) plasma levels were predictors of cannabis misuse in SIPD patients. Conclusions: Different clinical factors and biochemical parameters con be associated with SIPD according to the main substance of abuse, thus requiring specific management by clinicians.
Prophylactic Antibiotics before Gynecologic Surgery: A Comprehensive Review of Guidelines
Authors: Petousis Stamatios , Angelou Panagiota , Almperis Aristarchos , Laganà Antonio Simone , Titilas Gerasimos , Margioula-Siarkou Chrysoula , Dinas Konstantinos
Published: March 2024

Surgical site infections (SSIs) refer to infections in the incision, organ, or postoperative space. As common healthcare-associated infections, SSIs correlate with prolonged hospital stay, additional procedures, ICU stay, and higher mortality rates. Around 8–10% of gynecologic surgery patients may experience infectious complications, influenced by microbial contamination, surgical nature, and patient factors. The goal of this narrative review is to compare and merge recommendations from globally published guidelines concerning the utilization of antibiotics in the perioperative phase. A comparative descriptive/narrative review of the guidelines issued by the American College of Obstetrics and Gynecology (ACOG), Society of Obstetricians and Gynecologists of Canada (SOGC), Royal College of Obstetricians and Gynecologists (RCOG), National Institute for Health and Care Excellence (NICE), Royal Australian and New Zealand College of Obstetricians and Gynecologists (RANZCOG), European Society of Gynecologic Oncology (ESGO), Société Française d’ Anésthesie et de Réanimation (SFAR), Spanish Society of Infectious Diseases and Clinical Microbiology (SEIMC), and Hellenic Society of Obstetrics and Gynecology (HSOG) was conducted. For hysterectomy, first/second-generation cephalosporins are suggested, with metronidazole as an option. Laparoscopy without entering the bowel or vagina typically does not require prophylaxis. Uterine evacuation and hysteroscopy may involve doxycycline or azithromycin based on risk factors, whereas, for vulvectomy, cefazolin is recommended. Urogynecology procedures may include cefazolin with metronidazole. In cases of penicillin allergy, cephalosporins are suggested, and, for obese patients, adjusted doses are advised. Additional doses may be needed for prolonged procedures or excessive blood loss. Timing recommendations are 15–60 min before incision, adjusting for specific antibiotics. Clear indications exist for certain surgeries like hysterectomy, termination of pregnancy, and urogynecologic procedures. Conversely, procedures such as intrauterine device insertion, hysteroscopy, and laparoscopy typically do not necessitate antibiotic prophylaxis. For several other procedures, the evidence is inconclusive, while considering dose, timing, and indications can mitigate infectious complications and provide benefits for the healthcare system.
Empirical Distribution of the U.S. Housing Market during the Great Recession: Nonlinear Scaling Behavior after a Major Crash
Authors: Siokis Fotios M.
Published: March 2024

This study focuses on the real estate bubble burst in the US housing market during 2007–2008. We analyze the dynamics of the housing market crash and the after-crash sequence during the Great Recession. When a complex system deviates away from its typical path by the occurrence of an extreme event, its behavior is strongly characterized as nonstationary with higher volatility. With the utilization of a robust method, we present the characteristics of the aftershock period and provide useful information about the spatial distribution and the decay process of the aftershock sequence in terms of time. The returns of the housing price indices are well approximated by the empirics of a power law. Although we deal with low-frequency data, a time power-law relaxation pattern is identified. Our findings align with those in geophysics, indicating that the value of the relaxation parameter typically hovers around one and varies across different thresholds.
Research on Performance Improvement of Emulsified Asphalt Mixture Based on Innovative Forming Process
Authors: Xiao Ke , Qu Xin , Jiang Yong , Yun Wenyang , Zheng Pengfei , Li Weicheng
Published: March 2024

Bulk density and porosity have great influence on the technical performance of an emulsified asphalt mixture, so in order to enhance the strength of the asphalt mixture, bulk density should be improved and porosity should be reduced. Considering the forming process of the emulsified asphalt mixture, the decrease in porosity can ensure the state of the mixture. In order to reduce the porosity of the emulsified asphalt mixture, an innovative forming process is proposed to improve the performance of the emulsified asphalt mixture, and its strength formation mechanism is explored in this paper. Three groups of emulsified asphalt mixtures (ARC-8 + SBR, SMA-5 + EVA, SMA-5 + SBR) were prepared by a conventional mixing process and novel mixing process. Marshall test of the emulsified asphalt mixture, CT scanning test of the emulsified asphalt mixture, workability test and analysis were manufactured and tested. The results show that, compared with conventional methods, the innovative forming method can increase the bulk density of the mixture and reduce the porosity, and thus improve its technical performance. The reason is that most of the water in the mixture of the innovative forming method sticks to the outer surface of the fine aggregate, and the water is more easily discharged. Secondly, the fine aggregate of the innovative forming method is directly mixed with the emulsion, and the volume is smaller. The emulsion wraps the fine aggregate in it due to the surface tension, which enhances the adhesion effect, thus improving the strength of the mixture.
MOP−18−Derived CuO Fiber for Hybrid Supercapacitor Electrodes
Authors: Haque Syed Fahad Bin , Balkus Kenneth J. , Ferraris John P.
Published: March 2024

This study explores a simple method of fabricating hybrid supercapacitor electrodes, which could potentially broaden the application of this technology. The method involves electrospinning a uniform solution of Matrimid/Metal−Organic Polyhedra 18 (MOP−18) followed by carbonization at a relatively low temperature of 700 °C in air, rather than in an inert atmosphere, to create free−standing, redox−active hybrid supercapacitor electrodes. Additionally, the synthesis procedure requires no stabilization or activation steps, which enhances the cost effectiveness of the synthesized electrode materials. The resulting C/CuO composite was used as the working electrode, with a polyacrylonitrile (PAN)/Poly(methyl methacrylate) (PMMA) carbon nanofiber (CNF) electrode as the counter and 6 M KOH as the electrolyte in a T−cell configuration. The cell performance and redox activity were evaluated using cyclic voltammetry (CV), galvanostatic charge–discharge (GCD), electrochemical impedance spectroscopy (EIS) and cycling stability tests. Additionally, the physical and chemical structures of the electrode materials were assessed using X−ray photoelectron spectroscopy (XPS), scanning electron microscopy (SEM), transmission electron spectroscopy (TEM), X−ray diffractometry (PXRD), surface area analysis and other characterization techniques. The electrode material demonstrated a specific capacitance of up to 206 F/g. Supercapacitors utilizing this material display an energy density of 10.3 Wh/kg (active material) at a current density of 1 A/g in electrochemical testing.
Minimizing Tissue Injury and Incisions in Multilevel Biportal Endoscopic Spine Surgery: Technical Note and Preliminary Results
Authors: Kim Seung-Kook
Published: March 2024

Background and Objectives: Biportal endoscopic spine surgery (BESS) is a promising technique that can be applied for the treatment of various spinal diseases. However, traditional BESS procedures require multiple, separate incisions. We present, herein, various techniques to reduce the number of incisions in multi-level surgery and their clinical outcomes. Materials and Methods: Three different techniques were used to reduce the number of incisions for the preservation of normal tissue associated with BESS: the step-ladder technique, employing a common portal for the scope and instruments; the portal change technique employing a two-level procedure with two incisions; and the tilting technique, employing more than three levels. Pain (Visual Analog Scale), disability (Oswestry Disability Index), and patient satisfaction were evaluated before and 12 months after the procedure. Results: Among the 122 cases of multilevel spine surgery, 1.43 incisions per level were employed for multilevel BESS. Pain and disability showed significant improvement. Patient satisfaction showed favorable results. Conclusions: Combining multiple techniques during biportal surgery could decrease the number of incisions needed and preserve musculature with favorable clinical outcomes.
The Angular Velocity as a Function of the Radius in Molten Ga75In25 Alloy Stirred Using a Rotation Magnetic Field
Authors: Roósz András , Rónaföldi Arnold , Svéda Mária , Veres Zsolt
Published: March 2024

The simulation of the solidification of alloys (like steel or aluminium alloys), which is carried out by using the melt flow induced by a rotation magnetic field (RMF), needs the correct angular velocity vs. the radius function of the melt. Because it is impossible to directly obtain information about the melt flow from industrial casting, this information can only be obtained from well-monitored experiments using low-melting-point metals or alloys (e.g., Hg, Ga, GaIn, and GaInSn). In this work, we first summarized the measuring methods that are suitable for determining this function and analysed their advantages and disadvantages. All of them disturb, to some degree, the melt flow, except for the Pressure Compensation Method (PCM); therefore, this method was used in the experiments. Closed TEFLON crucibles with a 60 mm length and 12.5 mm radius and Ga75wt%In25wt% alloy was used. The angular velocity (ω) was calculated from the compensation pressure measured at r = 5, 7.5, 10, and 12.5 mm in the 0–90 mT range of magnetic induction, B. Based on the ω(B, r) dataset, a suitable ω(B, r) function was determined for the simulation.
A Sustainable Synthetic Approach to Tacrine and Cholinesterase Inhibitors in Deep Eutectic Solvents under Aerobic Conditions
Authors: Cicco Luciana , Perna Filippo Maria , Capriati Vito , Vitale Paola
Published: March 2024

An enhanced, sustainable, and efficient method for synthesizing tacrine, achieving a 98% yield, has been developed by replacing volatile organic compounds with more eco-friendly solvents such as deep eutectic solvent (DESs). The optimized protocol scales easily to 3 g of substrate without yield loss and extends successfully to tacrine derivatives with reduced hepatotoxicity. Particularly notable is the synthesis of novel triazole-based derivatives, yielding 90–95%, by integrating an in situ preparation of aryl azides in DESs with N-propargyl-substituted tacrine derivatives. Quantitative metrics validate the green aspects of the reported drug development processes.
Organotransition Metal Chemistry of Terpenes: Syntheses, Structures, Reactivity and Molecular Rearrangements
Authors: McGlinchey Michael J.
Published: March 2024

The impact of organometallic chemistry on the terpene field only really blossomed in the 1960s and 1970s with the realisation that carbon–carbon bond formation under mild conditions could be achieved by using nickel or iron carbonyls as synthetic reagents. Concomitantly, the development of palladium derivatives capable of the controlled coupling of isoprene units attracted the attention of numerous highly talented researchers, including future Nobel laureates. We discuss briefly how early work on the syntheses of simple monoterpenes soon progressed to sesquiterpenes and diterpenes of increasing complexity, such as humulene, flexibilene, vitamin A, or pheromones of commercial value, in particular those used in perfumery (muscone, lavandulol), or grandisol and red scale pheromone as replacements for harmful pesticides. As the field progressed, there has been more emphasis on developing organometallic routes to enantiopure rather than racemic products, as well as gaining precise mechanistic data on the transformations, notably the course of metal-promoted molecular rearrangements that have long been a feature of terpene chemistry. We note the impact of the enormously enhanced analytical techniques, high-field NMR spectroscopy and X-ray crystallography, and their use to re-examine the originally proposed structures of terpenes and their organometallic derivatives. Finally, we highlight the very recent ground-breaking use of the crystalline sponge method to acquire structural data on low-melting or volatile terpenes. The literature cited herein covers the period 1959 to 2023.
Synthesis and Unique Behaviors of High-Purity HEA Nanoparticles Using Femtosecond Laser Ablation
Authors: Fieser David , Lan Yucheng , Gulino Antonino , Compagnini Giuseppe , Aaron Doug , Mench Matthew , Bridges Denzel , Shortt Hugh , Liaw Peter , Hu Anming
Published: March 2024

High-entropy alloys (HEAs) are a class of metal alloys consisting of four or more molar equal or near-equal elements. HEA nanomaterials have garnered significant interest due to their wide range of applications, such as electrocatalysis, welding, and brazing. Their unique multi-principle high-entropy effect allows for the tailoring of the alloy composition to facilitate specific electrochemical reactions. This study focuses on the synthesis of high-purity HEA nanoparticles using the method of femtosecond laser ablation synthesis in liquid. The use of ultrashort energy pulses in femtosecond lasers enables uniform ablation of materials at significantly lower power levels compared to longer pulse or continuous pulse lasers. We investigate how various femtosecond laser parameters affect the morphology, phase, and other characteristics of the synthesized nanoparticles. An innovative aspect of our solution is its ability to rapidly generate multi-component nanoparticles with a high fidelity as the input multi-component target material at a significant yielding rate. Our research thus focuses on a novel synthesis of high-entropy alloying CuCoMn1.75NiFe0.25 nanoparticles. We explore the characterization and unique properties of the nanoparticles and consider their electrocatalytic applications, including high power density aluminum air batteries, as well as their efficacy in the oxygen reduction reaction (ORR). Additionally, we report a unique nanowire fabrication phenomenon achieved through nanojoining. The findings from this study shed light on the potential of femtosecond laser ablation synthesis in liquid (FLASiL) as a promising technique for producing high-purity HEA nanoparticles.
Effect of Anisotropy of Reduced Graphene Oxide on Thermal and Electrical Properties in Silicon Carbide Matrix Composites
Authors: Broniszewski Kamil , Woźniak Jarosław , Cygan Tomasz , Kostecki Marek , Moszczyńska Dorota , Chmielewski Marcin , Dydek Kamil , Olszyna Andrzej
Published: March 2024

Reduced graphene oxide, due to its structure, exhibits anisotropic properties, which are particularly evident in electrical and thermal conductivity. This study focuses on examining the influence of reduced graphene oxide in silicon carbide on these properties in directions perpendicular and parallel to the direction of the aligned rGO flakes in produced composites. Reduced graphene oxide is characterized by very high in-plane thermal and electrical conductivity. It was observed that the addition of rGO increases thermal conductivity from 64 W/mK (reference sample) up to 98 W/mK for a SiC–3 wt.% rGO composite in the direction parallel to the rGO flakes. In the perpendicular direction, the values were slightly lower, reaching up to 84 W/mK. The difference observed in electrical conductivity values is more significant and is 1–2 orders of magnitude higher for the flakes’ alignment direction. The measured electrical conductivity increased from 1.2710−8 S/m for the reference SiC sinter up to 1.55 × 10−5 S/m and 1.2410−4 S/m for the composites with 3 wt.% rGO for the perpendicular and parallel directions, respectively. This represents an enhancement of four orders of magnitude, with a clearly visible influence of the anisotropy of the rGO. The composite’s enhanced electrical and thermal conductivity make it particularly attractive for electronic devices and high-power applications.
The Inhibitory Effect of Early Pregnancy Factor on Red Meat Neu5Gc-Mediated Antibody Production in CMAH−/− Mice
Authors: Wang Cong , Ren Honglin , Wang Han , Li Haosong , Guo Jian , Xiao Yiran , Guo Yuxi , Liu Mengdi , Duan Fuchun , Hu Pan , Li Yansong , Liu Zengshan , Lu Shiying
Published: March 2024

The meat derived from mammals such as cows, sheep, and pigs is commonly referred to as red meat. Recent studies have shown that consuming red meat can activate the immune system, produce antibodies, and subsequently develop into tumors and cancer. This is due to the presence of a potential carcinogenic compound in red meat called N-ethanol neuraminic acid (Neu5Gc). Neu5Gc is a common sialic monosaccharide in mammals, synthesized from N-acetylneuraminic acid (Neu5Ac) in the body and typically present in most mammals. However, due to the lack of the CMAH gene encoding the cytidine 5′-monophosphate Neu5Ac hydroxylase, humans are unable to synthesize Neu5Gc. Compared to primates such as mice or chimpanzees, the specific loss of Neu5Gc expression in humans is attributed to fixed genome mutations in CMAH. Although Neu5Gc cannot be produced, it can be introduced from specific dietary sources such as red meat and milk, so it is necessary to use mice or chimpanzees that knock out the CMAH gene instead of humans as experimental models. Further research has shown that early pregnancy factor (EPF) has the ability to regulate CD4+T cell-dependent immune responses. In this study, we established a simulated human animal model using C57/BL6 mice with CMAH gene knockout and analyzed the inhibitory effect of EPF on red meat Neu5Gc-induced CMAH−/− C57/BL6 mouse antibody production and chronic inflammation development. The results showed that the intervention of EPF reduced slow weight gain and shortened colon length in mice. In addition, EPF treatment significantly reduced the levels of anti Neu5Gc antibodies in the body, as well as the inflammatory factors IL-6 and IL-1β, TNF-α and the activity of MPO. In addition, it also alleviated damage to liver and intestinal tissues and reduced the content of CD4 cells and the expression of B cell activation molecules CD80 and CD86 in mice. In summary, EPF effectively inhibited Neu5Gc-induced antibody production, reduced inflammation levels in mice, and alleviated Neu5Gc-induced inflammation. This will provide a new re-search concept and potential approach for developing immunosuppressants to address safety issues related to long-term consumption of red meat.