bluuebunny/crossref_metadata_2025 huggingface dataset:
Effect of Rented Warehouses for Deteriorating Items Under Stock Dependent Demand, Partial Backlogging
Authors: Sharma Sanjay , Tyagi Anand , Verma BB , Kumar Sachin
Published: November 2023

In the area of two warehouse-based inventory models, various studies have been carried out, and the authors presented their models under different parameters and environmental conditions. In most of the study, it can be seen that one warehouse was assumed to be its own warehouse and other was assumed to be rented. Due to different facilities and conditions, both warehouses have different rates of demand and deterioration, along with different storage capacities. A study has already been done by considering both warehouses as ranted. It was also assumed in the study that both warehouses had the same capacity. In addition, it has also been assumed that the items in the second ranted warehouse start decaying after some time, whereas the items in the first warehouse were used first to meet the demand of the customers. After critically reviewing the model published on two ranted warehouses, it can be observed that the storage techniques of items need to be further explored, as the model used the items from the first warehouse to satisfy the demand of the customers, while the items whose deterioration was about to start were stored in the second warehouse. This concept of storage has to change, as items in the second warehouse totally deteriorate until their turn comes up. Keeping this fact in mind, we have developed an inventory model based on two different warehouses for deteriorated items whose rate of deterioration is not so high, but after a very short period of time, these items start decaying. According to the current model, the demand of the customers has been satisfied in the first warehouse; to avoid deterioration in the second warehouse, as a result, transfer such items whose deterioration is about to start from the second warehouse to the first warehouse so that deterioration of the items must be minimize. In the current model, it has been assumed both warehouses are rented, which is suitable for the manufacturer whose product demand is very high and space is not enough. It is obvious that the demand for the items in the stock increases due to the stock reaching a certain level. In the model, the demand for the first warehouse is assumed to be stock-dependent. When, there is extra stock, the second warehouse is used for the products, and author also assumed that the demand has become constant. The model is also instigated under sensitivity analysis, and a brief numerical example with real data has been illustrated.
Ant Metaheuristic Algorithm for the Frequency Assignment Problem
Authors: Alrajhi Khaled
Published: November 2023

This study proposes the ant metaheuristic algorithm to solve the frequency assignment problem. In this approach, the descent method constructed as three ants which each of which appling a metaheuristics algorithm. Several novel and existing techniques are used to improve the performance of this algorithm. One of these techniques is applying the concept of a well-known graph colouring algorithm, namely recursive largest first. Furthermore, this study compares this algorithm using two visibility definitions. The first definition is based on the number of feasible frequencies and the second one is based on the degree. Additionally, we compare this algorithm using two trail definitions. The first one is between requests and frequencies. The second is between requests and requests. This study considers real and randomly generated benchmark datasets of the static problem and our algorithm achieved competitive results comparing with other ant colony optimization algorithms in the literature.
ON A SPECIAL CLASS OF SCHWARTZ FUNCTIONS
Authors: Obradovic M. , Tuneski N.
Published: November 2023

In this paper we study functions $ \omega(z) = c_1z+c_2z^2+c_3z^3+\cdots$ analytic in the open unit disk $\D$ and such that $|\omega'(z)|\le1$ for all $z\in\D$. For these functions we give estimates (sometimes sharp) for the following moduli: $|c_3-c_1c_2|$, $|c_1c_3-c_2^2|$, and $|c_4-c_2^2|$.
First report on establishment and characterization of the extrahepatic cholangiocarcinoma sarcoma cell line CBC2T-2
Authors: Jiang Ning-Zu , Bai Ming-Zhen , Huang Chong-Fei , Ma Ze-Long , Zhong Ru-Yang , Fu Wen-Kang , Gao Long , Tian Liang , Mi Ning-Ning , Ma Hai-Dong , Lu Ya-Wen , Zhang Zi-Ang , Zhao Jin-Yu , Yu Hai-Ying , Zhang Bao-Ping , Zhang Xian-Zhuo , Ren Yan-Xian , Zhang Chao , Zhang Yong , Yue Ping , Lin Yan-Yan , Meng Wen-Bo
Published: November 2023

Inflammatory bowel disease (IBD) has as a main characteristic the exacerbation of the immune system against enterocytes, compromising the individual’s intestinal microbiota. This inflammatory cascade causes several nutritional deficiencies, which further compromise immunological functioning and, as a result, worsen the prognosis. This vicious cycle can be interrupted as the patient’s dietary pattern meets their needs according to their clinical condition, acting directly on the inflammatory process of IBD through the interaction of food, intestinal microbiota, and epigenome. Specific nutritional intervention for IBD has a crucial role in preventing and managing disease activity. This review addresses epigenetic modifications through dietary compounds as a mechanism for modulating the intestinal microbiota of patients with IBD.
Narrative Review on Prosthetic Reconstruction of Neurofibromatosis Cases Undergoing Hemi-Mandibu lectom
Authors: Soroush Mokhtari  , Jalal Toumaj  , Mohammad Reza Hezaveie  , Donya Maleki  , Morteza Faghani
Published: November 2023

Neurofibromatosis (NF) is an autosomal-dominant inherited syndrome with teeth retention and complex tooth deficiencies which can affect swallowing, speech, esthetic, and airway patency. That’s where the rehabilitation of structures, functions, esthetics deformities, and life quality with different prosthetic choices should be considered. The present literature review inspected the prosthetic treatment plans to rehabilitate NF type 1 after hemi-mandibulectomy. By an extensive literatures search, some articles were chosen. The prosthetic treatment options for dental reconstruction of the hemi-mandibulectomy can be conventional removable prostheses, implant-supported fixed protheses, and implant-supported removable protheses. Ultimately, choosing among prosthetic treatment plans is made based on clinician opinion, patient preference, and ridge condition in each case.
Identifikasi Determinan Pembiayaan Rantai Pasokan UMKM
Authors: Niken Permata Sari  , Artha Bhenu , Cahya Purnama Asri  , Utami Tunjung Sari  , Antonius Satria Hadi
Published: November 2023

Pembiayaan rantai pasokan merupakan hal yang penting bagi UMKM. Alternatif pembiayaan jangka pendek yang dapat memberikan bantuan untuk memperbaiki masalah kredit dan meningkatkan kinerja keuangan juga diperlukan UMKM. Tujuan penelitian ini adalah mengetahui pengaruh teknologi digital, kolaborasi, dan institusi keuangan terhadap pembiayaan rantai pasokan UMKM. Penelitian ini termasuk kuantitatif, yang menggunakan kuesioner sebagai instrumen pengumpulan data. Sampel ditetapkan dengan metode purposive sampling, dan dalam penelitian ini diperoleh 95 responden. Hasil penelitian menunjukkan bahwa teknologi digital, kolaborasi, dan institusi keuangan berpengaruh positif signifikan terhadap pembiayaan rantai pasokan UMKM.
Un análisis Crítico de la Evolución del Sector Energético en México y Factibilidad de la Propuesta de Reforma al Sector Eléctrico
Authors: Gómez Cárdenas Raúl
Published: November 2023

Este artículo tiene por objetivo describir y analizar la evolución del sector energético mexicano en los últimos años, así como el efecto que ha tenido la política energética del gobierno federal en esta evolución, a través de las distintas reformas legales que se han aplicado en las industrias petrolera y eléctrica nacionales.  La metodología aplicada en esta investigación consta de una revisión documental de los diferentes autores que contribuyen a esta temática; una investigación descriptiva que caracteriza la evolución del sector energético y la política aplicada por el gobierno mexicano, para, finalmente, integrar una propuesta que integre los elementos encontrados. Se parte de la hipótesis de que ha sido la incapacidad financiera del gobierno mexicano la que ha debilitado a las empresas nacionales, Pemex y CFE; debilidad que ha motivado la apertura gradual del sector a la participación privada, hasta llegar a la reforma energética de 2013, en que el Estado mantiene la rectoría parcial de las industrias petrolera y eléctrica, pero fomenta un mercado abierto para actividades importantes.
Perancangan Aplikasi Pencatatan Transaksi Berbasis Web Studi Kasus Lapak Limbah Plastik dan Kain Handoko
Authors: Marcopollo Marcopollo , Simorangkir Holder , Malabay Malabay
Published: November 2023

Lapak Limbah Plastik dan Kain Handoko yang berlokasi di Jalan Teluk Naga Tugu No. 35, RT 001RW 001, Teluknaga Seliong, Kecamatan Teluknaga, Kabupaten Tangerang, Banten merupakan perusahaanyang berfokus pada kegiatan jual beli limbah plastik dan kain. Proses pencatatan transaksi yang dilakukanoleh Lapak Limbah Plastik dan Kain Handoko masih menggunakan sistem secara manual, akibatnya seringterjadi kesalahan perhitungan dan pencatatan sehingga Lapak Limbah Plastik dan Kain Handoko harusmenombok jika terjadi selisih antara sisa stok barang dengan catatan transaksi. Untuk mengatasipermasalahan tersebut dibangun aplikasi pencatatan transaksi berbasis web. Dalam perancangan aplikasi ini,digunakan bahasa pemrograman PHP dengan framework CodeIgniter, dan MySQL sebagai pengolahdatanya. Metode Perancangan yang digunakan adalah metode Web Development Life Cycle (WDLC).Dalam proses pengumpulan data, metode yang digunakan meliputi observasi langsung, wawancara, dan studipustaka atau literatur. Aplikasi ini diharapkan dapat mengatasi permasalahan mengenai proses pencatatantransaksi pembelian dan penjualan di Lapak Limbah Plastik dan Kain Handoko, sehingga meningkatkanefisiensi dan keakuratan dalam pengelolaan data transaksi.
Penerapan Search Engine Optimization (SEO) Untuk Meningkatkan Penjualan Pada Toko Javy Petshop
Authors: Alexander Jeremy Lorenzo Taolin  , Wiwin Windihastuty
Published: November 2023

Javy Petshop adalah sebuah badan usaha yang bergerak dalam bidang penjualan produk danjasa yang berhubungan dengan hewan peliharaan. Javy Petshop berlokasi di Luwi Orok, Jl. RayaParungkuda, Sundawenang, Kec. Parung Kuda, Sukabumi Regency, Jawa Barat. Permasalahan yangsaat ini sedang dihadapi oleh Javy Petshop adalah terhalangnya akses terhadap toko akibatpembangunan jalan tol, mengakibatkan penurunan dalam penjualan, dan kesulitan dalam melakukanpromosi. Dari latar belakang tersebut, penelitian ini ditujukan untuk membuat website e-commerceyang sudah terhubung dengan basis data, memiliki fitur pemasaran dan promosi, dapat mencetaklaporan, serta mengetahui status pengiriman. Penulismenggunakan Business Model Canvas (BMC)untuk menganalisa data yang dikumpulkan melalui wawancara dan observasi. Informasi yangdidapat kemudian digunakan untuk melakukan analisa sistem e-commerce, mengimplementasikansearch engine optimization, danmelakukan strategi marketing 4P yaitu product, price, place, danpromotion. Hasil akhir dari penelitian ini penulis dapat menggunakan strategi marketing dan sosialmedia untuk melakukan promosi, mencetak laporan periode, menyimpan informasi mengenaipemesanan produk, dan membuat katalog yang menyimpan detail produk.
Efecto del gasto y la estancia en la composición del mercado de turistas internacionales en las denominaciones de origen de AOVE en Andalucía
Authors: MERCADÉ MELÉ PERE , Vena Oya Julio , Barreal Pernas Jesús
Published: November 2023

La estacionalidad y volatilidad del sector primario hace que muchas regiones hayan visto al turismo como una actividad clave para el desarrollo de estas zonas situadas principalmente en el interior de Andalucía. En este sentido, las denominaciones de origen protegidas ofrecen una mayor percepción de seguridad y calidad para los turistas que visitan una zona por motivos gastronómicos. El objetivo de esta investigación es conocer los distintos perﬁles de los turistas internacionales para ayudar a establecer en estas zonas una oferta de turismo estable que complemente sus ingresos a través de la identiﬁcación de diferentes segmentos que pueden resultar atractivos para ellos. Para ello, se ha utilizado una regresión de clases latentes, donde se han encontrado cuatro segmentos (jóvenes solitarios, mayores tradicionales, mayores culturales y jóvenes gourmet) que diﬁeren respecto de su gasto y estancia. Finalmente, se recogen una serie de recomendaciones en base a estos grupos identiﬁcados.
The importance of the top exporter in regional exports
Authors: Requena Silvente Francisco , De Lucio Juan , Mínguez Raúl , Minondo Asier
Published: November 2023

We use Spanish firm-level data over the period 1998-2018 to examine the importance of the top exporter in terms of NUTS III (provincial) exports. We find that: (1) the top exporter in each province represents about one fifth of total exports per year; (2) firms contribute to export growth whilst on their way towards the top position but once the latter is reached their growth contribution becomes marginal; and (3), shocks to the top exporter of a province explain the fluctuations in aggregate exports growth.
Detection of a ∼0.1c Radio Knot in M81* Associated with a Moderate X-Ray Flare
Authors: Wang Xuezheng , Jiang Wu , Shen Zhiqiang , Yan Zhen , Li Ya-Ping , Martí-Vidal Ivan , Gold Roman
Published: November 2023

Through very long baseline interferometry observations of one of the closest low-luminosity active galactic nuclei, M81*, at multiple frequencies of 8.8, 22, and 44 GHz, a bright discrete knot with an unusual low apparent speed ∼0.1c was detected. Combined with the contemporaneous monitoring of X-ray data at 2–10 keV, our data indicate that a moderate X-ray flare happened when the knot was launched from the core region. Three possible origins of the knot are proposed to explain our observational results. They are an episodic jet ejection, a low-speed shock wave, and a possible secondary black hole in a binary system. Future intensive multiwavelength monitoring can help to understand the discrete knot as well as the central black hole better.
Hidden Companions to Intermediate-mass Stars. XIII. Discovery of a 0.80 M
⊙, 4.3 au Companion to HIP 7298*
Authors: Waisberg Idel , Klein Ygal , Katz Boaz
Published: November 2023

Proper motion changes between astrometric surveys provide a hint for unresolved companions and near-infrared interferometry is arguably the most efficient way to reveal or constrain their nature. Here we report on the VLTI/GRAVITY. detection of a companion to the nearby star HIP 7298 with a K band flux ratio of 11.9% at a projected separation ρ = 57.1 mas ↔ 4.3 au. Through isochrone fitting we find that the primary is a 1 Gyr old M

A
 = 1.56M
⊙ star while the newly discovered secondary is a M

B
 = 0.80M
⊙ K dwarf. The stars will most likely avoid common envelope evolution and will become a system similar to Gliese 86 in about 1.5 Gyr.
La diversité des aires marines protégées masque un modèle générique : est-il soluble dans des réalités diversifiées ?
Authors: Beuret Jean-Eudes , Cadoret Anne
Published: November 2023

L’analyse comparative de 13 aires marines protégées réparties sur 5 continents permet de montrer l’existence d’un modèle générique en grande partie implicite, puis d’en identifier les composantes. Elles portent sur les acteurs, ce qui légitime la décision, les temporalités et les vecteurs de la décision. Dans le registre de l’action, elles portent sur le rapport à l’espace, à la nature, à l’échange et sur le format de l’action. Ce modèle engendre des difficultés d’acceptation et des conflits : y répondre suppose de relever des défis d’adaptation locale et de réinvention globale. Différents processus d’adaptation ont été identifiés. Revenir sur ce modèle suppose d’interroger ses déterminants, parmi lesquels figurent des colonialités et des formes de colonialisme vert et bleu. Classification JEL   : Q5, Q56, Q57, Q58
Effect of Negative Automatic Thoughts on Medication Adherence in Individuals With Schizophrenia
Authors: Üşenmez Tülay Yıldırım , Şanli Mehmet Emin
Published: November 2023

This study aimed to determine the effect of negative automatic thoughts on medication adherence in individuals with schizophrenia. This was a cross-sectional study carried out in a community mental health center between October 2022 and December 2022. The study included 102 individuals with schizophrenia. Data was collected using the Descriptive Characteristics Form, Negative Automatic Thoughts Questionnaire (NAT-Q), and Morisky Medication Adherence Scale (MMAS). The individuals' total mean NAT-Q score was 106.34 ± 27.32. There was a strong negative correlation between NAT-Q and MMAS scores (
r
= −0.822,
P
< 0.05). The study found that negative automatic thoughts predicted medication adherence by 67%. The negative automatic thoughts of the individuals were high and the medication adherence of half of the individuals was low. It was determined that the level of negative automatic thoughts of individuals with schizophrenia may negatively affect their medication adherence.

[
Psychiatr Ann
. 2023;53(11):518–524.]
Adaptive clustering algorithm based on improved marine predation algorithm and its application in bearing fault diagnosis
Authors: Zhao Zhuanzhe , Wang Mengxian , Liu Yongming , Liu Zhibo , Lu Yuelin , Chen Yu , Tu Zhijian
Published: November 2023

In cluster analysis, determining the number of clusters is an important issue because there is less information about the most appropriate number of clusters in the real problem. Automatic clustering is a clustering method that automatically finds the most appropriate number of clusters and divides instances into the corresponding clusters. In this paper, a novel automatic clustering algorithm based on the improved marine predator algorithm (IMPA) and K-means algorithm is proposed. The new IMPA utilizes refracted opposition-based learning in population initialization, generates opposite solutions to improve the diversity of the population and produces more accurate solutions. In addition, the sine-cosine algorithm is incorporated to balance global exploration and local development of the algorithm for dynamic updating of the predator and prey population positions. At the same time, the Gaussian-Cauchy mutation is combined to improve the probability of obtaining the globally optimal solution. The proposed IMPA is validated with some benchmark data sets. The calculation results show that IMPA is superior to the original MPA in automatic clustering. In addition, IMPA is also used to solve the problem of fault classification of Xi*an Jiaotong University bearing data. The results show that the IMPA has better and more stable results than other algorithms such as the original MPA, whale optimization algorithm, fuzzy C-means and K-means in automatic clustering.
Five years of RTI regime in Sri Lanka: factors causing low proactive disclosure of information and possible remedies
Authors: Sumanadasa M.
Published: November 2023

Statutory obligations are imposed upon ministers by sections 8 and 9 of the Right to Information Act (RTI Act)1, while Regulation No. 202 issues guidelines for public authorities on the proactive disclosure of information through a digital or electronic format. However, slow progress in implementing proactive disclosure measures and the resultant absence of vital information on digital platforms in a constantly updated and user-friendly manner is not only a failure of the public authority to comply with legal obligations to disclose information proactively but also causing a further delay in realising full benefits of the RTI Act by the citizen. This paper examines the present status of the proactive disclosure of information by public authorities in terms of the RTI Act and analyses factors that cause the low performance.  Secondary data, particularly results of two studies in 2017 and 2020 undertaken by Verité Research and the Right to Information Commission (RTIC), respectively, have been analysed using descriptive methods. The study found that a key factor causing the low proactive online disclosure is the absence of practices of modern record management and the near absence of proper identification of ‘records’ or ‘information’ generated by public authorities by indexing and cataloguing and by maintaining regularly updated schedules of records. The second key factor found is the absence of a schedule of proactively disclosable records that is maintained constantly updated for monitoring such records. The lack of awareness and a clear knowledge of concepts on the part of state officials are also found as critical issues. The study recommends that all public authorities maintain (a) a general records schedule [common to all agencies]; and (b) an agency records schedule [unique to the agency], preferably in electronic format, and update the same on a daily basis. It is also recommended that a public authority maintains a schedule of proactively disclosable records called a “Proactive Disclosure Matrix”, preferably in electronic format and updates the same on a daily basis.
Gendered state: ‘Governmentality’ and the labour migration policy of Sri Lanka
Authors: Gunaratne Jayathry
Published: November 2023

Governments’ use of their authority to control the behaviour of the citizens through ‘mechanisms of management’ such as education, laws, rules, and regulations is discussed widely in Michael Foucault’s concept of ‘governmentality’. Built on this standing, this paper intends to investigate how the government of Sri Lanka uses different policy initiatives over time to control the behaviour of a categorized group of its citizens i.e., unskilled female migrant workers. The research analyses the labour migration policies implemented by successive governments of Sri Lanka since late 1970s to post COVID-19 period to examine this statement. It argues that the government re-produces traditional gender norms through laws and regulations to regulate the movements of unskilled female migrant workers aiming to achieve its policy interests. The paper also discusses how the most recent labour migration policy controls women’s right to migration by interpreting the aspects of ‘Family Background Report’. This study adopts a combined method; while reviewing secondary data i.e., laws, regulations, and existing literature on related areas be the main source of data for the study, findings will be complemented by empirical data collected through structured interviews with government officials. This research concludes by revealing how the government of Sri Lanka has utilized its ‘mechanisms of management’ to control the right to work of a selected segment of females by applying its authority. It further explains how these laws and regulations have been changed over time to cater the policy interests of the succeeding governments.
Exploring the Agreement Between Perceived Rankings and Outcome Data Rankings for Professional Athletic Training Programs
Authors: Branning Sarah E. , Crossway Ashley K. , Neil Elizabeth R. , Voll Craig A. , Winkelmann Zachary K.
Published: November 2023

Context

The U.S. News & World Report college ranking system is used to describe the best graduate programs in the country. Rankings of graduate programs are based solely on perceived ratings of quality by directors and/or deans. Athletic training is not listed by U.S. News & World Report; however, the Commission on Accreditation of Athletic Training Education (CAATE) reports key metrics such as the Board of Certification pass rate and program graduation rate, which could be helpful to create rankings.

Objective

To evaluate and rank CAATE-accredited professional athletic training (PAT) programs using 2 models: (1) perceived rating of academic quality by program directors (PDs) and (2) CAATE outcome data.

Design

Cross-sectional with survey and retrospective data.

Setting

Web-based survey.

Patients or Other Participants

One hundred fifty-five PDs and 230 CAATE-accredited PAT programs.

Main Outcome Measure(s)

The perceived rating survey for the PDs resembled the U.S. News & World Report system using a 5-point Likert scale to assess the academic quality of each program. For the CAATE outcome data, we used publicly available information for each PAT program on the CAATE website. We ranked all PAT programs using the data from each model. A Cohen κ was performed to explore the agreement between the PDs’ perceived ranking and the CAATE outcome data rankings.

Results

No agreement was found between the perceived peer assessment and CAATE outcome data rankings (κ = −0.003, P = .401).

Conclusion

Perception by PDs did not align with objective data reported by CAATE. The lack of agreement between the 2 ranking systems highlights concerns about using the U.S. News & World Report system for graduate health programs. We suggest exploring a more robust and comprehensive formula including overall pass rate and graduation rate to identify top-ranked programs in athletic training.
Athletic Trainers’ Perceptions of and Experiences With Unlearning in Clinical and Educational Practice
Authors: Pike Lacy Alicia M. , Cavallario Julie M. , Lam Kenneth C. , Welch Bacon Cailee E.
Published: November 2023

Context

Unlearning is a critical component of evidence-based practice, yet research related to its role in athletic training practice is limited.

Objective

To explore athletic trainers’ (ATs’) perceptions of and experiences with unlearning.

Design

Cross-sectional.

Setting

Online survey with open-ended questions.

Patients or Other Participants

Seven hundred fifteen of 6925 ATs accessed the survey (access rate = 10.3%) with 640 ATs completing it (completion rate = 94%).

Main Outcome Measure(s)

We distributed a survey consisting of 8 to 10 demographic questions, 1 Likert-scale item on familiarity with unlearning, and 4 to 5 open-ended questions. Descriptive statistics summarize demographic information. Open-ended data were analyzed using the consensual qualitative research approach. Respondents who self-reported familiarity with unlearning were asked to described its meaning. To ensure data quality, these responses were compared with definitions of unlearning by 2 research team members. If consensus was reached that a participant’s understanding of unlearning aligned with the definitions, the remaining responses from that participant were included in the qualitative data analyses reported in this manuscript.

Results

Most respondents were minimally or not at all familiar with unlearning (n = 505/652, 77%). Approximately 46% (n = 181/391; 120 clinicians, 61 educators) accurately described the meaning of unlearning. Analysis of open-ended responses yielded 2 themes: barriers to unlearning and facilitators of unlearning. Reported barriers were intrinsic and extrinsic in nature and involved key stakeholders that frequently interact with ATs. Facilitators of unlearning included continued education, mentorship and team mindset, resources and evidence, and stakeholder education.

Conclusions

Respondents were largely unfamiliar with unlearning despite its role in promoting evidence-based practice. Continued education for ATs and relevant stakeholders is needed and may be accomplished through the creation and dissemination of accessible resources that highlight knowledge and skills that should be unlearned. These educational efforts may help to normalize unlearning in athletic training practice to continually improve the delivery of patient care.
Senescent tumor cells in colorectal cancer are characterized by elevated enzymatic activity of complexes 1 and 2 in oxidative phosphorylation
Authors: Shin Jun Sang , Kim Tae-Gyu , Kim Young Hwa , Eom So Yeong , Park So Hyun , Lee Dong Hyun , Park Tae Jun , Park Soon Sang , Kim Jang-Hee
Published: November 2023

Background: Cellular senescence is defined as an irreversible cell cycle arrest caused by various internal and external insults. While the metabolic dysfunction of senescent cells in normal tissue is relatively well-established, there is a lack of information regarding the metabolic features of senescent tumor cells.Methods: Publicly available single-cell RNA-sequencing data from the GSE166555 and GSE178341 datasets were utilized to investigate the metabolic features of senescent tumor cells. To validate the single-cell RNA-sequencing data, we performed senescence-associated β-galactosidase (SA-β-Gal) staining to identify senescent tumor cells in fresh frozen colorectal cancer tissue. We also evaluated nicotinamide adenine dinucleotide dehydrogenase–tetrazolium reductase (NADH-TR) and succinate dehydrogenase (SDH) activity using enzyme histochemical methods and compared the staining with SA-β-Gal staining. MTT assay was performed to reveal the complex 1 activity of the respiratory chain in in-vitro senescence model.Results: Single-cell RNA-sequencing data revealed an upregulation in the activity of complexes 1 and 2 in oxidative phosphorylation, despite overall mitochondrial dysfunction in senescent tumor cells. Both SA-β-Gal and enzyme histochemical staining using fresh frozen colorectal cancer tissues indicated a high correlation between SA-β-Gal positivity and NADH-TR/SDH staining positivity. MTT assay showed that senescent colorectal cancer cells exhibit higher absorbance in 600 nm wavelength.Conclusions: Senescent tumor cells exhibit distinct metabolic features, characterized by upregulation of complexes 1 and 2 in the oxidative phosphorylation pathway. NADH-TR and SDH staining represent efficient methods for detecting senescent tumor cells in colorectal cancer.
Quebrantamientos de medidas privativas de libertad en jóvenes infractores y factores de riesgo diferenciales
Authors: Arranz María , Maneiro Lorena , Cutrín Olalla , Gómez-Fraguela Xosé Antón
Published: November 2023

El quebrantamiento de medida en jóvenes que cumplen medidas judiciales privativas de libertad tiene graves consecuencias, tanto para los individuos como para la sociedad. Por ello, resulta necesario determinar los factores que contribuyen a la explicación de estas conductas. El objetivo de este estudio es evaluar las diferencias en una serie de factores de riesgo en función de la presencia y el tipo de quebrantamiento. La muestra estuvo compuesta por 177 jóvenes entre 16 y 22 años que cumplen alguna medida judicial privativa de libertad. La información fue obtenida a partir del Inventario de Gestión e Intervención con Jóvenes (IGI-J). Los resultados del estudio no evidenciaron diferencias en función del género. Sin embargo, algunas diferencias emergieron entre grupos analizados. Específicamente, el grupo de solo no retorno obtuvo puntuaciones significativamente más elevadas en factores de personalidad y actitudes. Estos resultados reflejan la necesidad de desarrollar herramientas de valoración del riesgo que tengan en cuenta este tipo específico de conductas.
A Study on the Effect of the Developmental Academic Advising Based on Student Engagement for University Freshman
Authors: Park Jihoe , Ko Jang Wan
Published: November 2023

The purpose of this study was to analyze the effects of the “Developmental Academic Advising Seminar” for first-year university students which was developed based on student engagement. To this end, the following three steps were taken. First, this study reviewed previous literature on academic advising and designed a developmental academic advising seminar centered on student engagement. Second, the seminar was provided to first-year university students for two hours per week for the first five weeks at “A” University in the Seoul metropolitan area. Third, the differences before and after the seminar participation were analyzed through the Wilcoxon Signed Ranks Test after conducting a pre- and post-test on learning motivation and educational effectiveness for participants. In addition, through interviews, the effects of the seminar were examined in terms of quality. The research results were as follows. First, developmental academic advising seminars showed a positive effect on increasing learning motivation, helping academic and career design, and improving satisfaction of faculty teaching methods and educational content. Second, academic advising focused on diverse student activities, helping them with self-reflection and their understanding of others. The results of this study suggest that teaching first-year university students should be conducted based on presentations and discussions focusing on student engagement, professional academic advising on self-reflection, and academic and career path designing, all of which are closely related to university life, rather than professor-centered lectures. This study is meaningful in that it was conducted for a small group of freshmen in order to analyze the contents of individual students' learning motivation and to make changes in educational effectiveness.
Designing and Conducting a Liberal Arts Course with Problem-Based Learning : A Case Study of ‘Great Speeches That Changed World History,’ an Open Class of S University
Authors: Park Su Jung
Published: November 2023

This paper describes a case study of ‘Great Speeches That Changed World History,’ a liberal arts course offered in the second semester of 2022 at S University. It aims to design and conduct the course as student-centered with Problem-Based Learning (PBL). The four steps of PBL, ‘meeting the problem → exploring the solution → resolving the problem → presenting and evaluating the solution’ were adapted for those of ‘planning a speech → lectures, discussions, and research → writing a speech and making PowerPoint slides → speech presentations and peer reviews.’ First, students were introduced to the problem of a ‘speech,’ which was designed as an ‘ill-structured, complex, real, and related-to-the-curriculum’ PBL problem. Then they decided on the purpose, topic, audience, and place of their speeches. The second step of exploring the solution consisted of the teacher’s lectures and the students’ subsequent discussions where they explored the topics of their mock speeches. For the third and fourth steps of PBL, students participated in a team project activity where they practiced and presented their mock speeches. Peer reviews helped students concentrate on other teams’ presentations and elicited integrative understanding and secondary learning from them. A survey on PBL’s effectiveness, conducted after 15 weeks of the course, showed that students understood the class materials better when engaging in a team project and responded positively to peer reviews. They also thought their team project helped them achieve the course objectives. In conclusion, PBL was an effective method to plan a student-centered course. Students got engaged in class actively and positively with PBL, which ultimately helped them achieve the course objectives.
Modeling a Community of Practice for Global Competence : A Collaborative Autoethnography of College EFL Learners
Authors: Oh EunJou , Kim Eun-Yong , Myeong MinJung , Jeon So-Hyeon , Kim Yeonjae , Jang Young-Hyeon , Yoon Sujin
Published: November 2023

In our increasingly interconnected contemporary society, the imperative of nurturing global citizenship and competence is evident when it comes to addressing the multifaceted challenges stemming from globalization. This study explores strategies for bridging the gap between in-class and out-of-class learning while expanding the reach of global competence into out-of-class learning settings. Building upon the General English course model by Oh (2021), which focuses on fostering global citizenship and competence, this research investigates the feasibility of implementing a supportive Community of Practice (CoP) model tailored for out-of-class learning environments. This study specifically assesses the potential of an online CoP model as a platform for the continuous cultivation and application of global citizenship and competence. Employing a collaborative autoethnographic approach, the research delves into the experiences of five university-level English as a Foreign Language (EFL) learners actively participating in this CoP. The research scrutinizes various dimensions of their engagement, encompassing their experiences within the CoP, prospective enhancements to the model, and the impact of digital tools on their learning journey, such as machine translation and ChatGPT on their learning journeys. The findings of this study illuminate the transformative effects of CoP activities on learners' attitudes, learning strategies, and the development of global citizenship and competence. Furthermore, it underscores the pivotal role of learners proactively harnessing technology, such as the ones mentioned above, in advancing both their level of global citizenship and their language proficiency. Additionally, the research underscores learners' comprehension of the rationale behind learning activities as a critical factor in fostering meaningful engagement. Ultimately, this research offers a blueprint for nurturing the essential skills and perspectives necessary for learners to evolve as engaged global citizens in an interconnected and interdependent world. It aligns with the imperative of fostering global competence in response to the pressi ng demands of our globali zed era.
Prevalence of malocclusion in adolescents according to sex, caries experience, gingival bleeding and smile dissatisfaction
Authors: Gonçalves Fonseca Mais Naiara , Cristina de Oliveira Santos Palma Liliane Cristina de Oliveira , De Castro Oliveira Carolina , Alves Pinto Rodrigo , Silvana Oliveira e Silva Carla , Sant'Ana Haikal Desirée
Published: November 2023

Objective: The propose of this study was to estimate the prevalence of malocclusion among adolescents and to assess the differences of this prevalence according to sex, experience of caries, gingival bleeding, and smile dissatisfaction. Methods: A cross-sectional study was conducted with 600 adolescents from 10 to 16 years old, who were identified and selected from public schools’ records. Intraoral and extraoral examinations were performed following World Health Organization recommendations and included: number of decayed, missing and filled teeth, presence of gingival bleeding, and occlusal condition. The latter was assessed based on information of Dental Aesthetic Index, and Foster and Hamilton Index, in addition to the evaluation of dental midline, facial and smile pleasantness according to Capelozza Filho classification. Smile dissatisfaction was also evaluated. Bivariate Poisson regression with robust variance was used to compare prevalence rates. Results: The prevalence of malocclusion, caries experience, gingival bleeding and smile dissatisfaction were 96.0%, 52.3%, 55.8%, and 49.4%, respectively. The prevalence of malocclusion was higher among adolescents with gingival bleeding. Statistically significant associations were noticed between crowding of the upper and lower anterior teeth and gingival bleeding, as well as among Class III molar relationship, deviation of the dental midline, anterior open bite, anterior crossbite, and caries experience. Smiles classified as acceptable or unpleasant were associated with dissatisfaction. Conclusion: These findings have evidenced a higher prevalence of malocclusion among adolescents and its association with caries experience, gingival bleeding, and smile dissatisfaction.
REVIEW OF CYPRUS ROTUNDUS LINN (MUSTA)
Authors: Sajwan Ankita , Kumar Thakur Basant
Published: November 2023

Cyperus rotundus belonging to Cyperaceae family is commonly known as Motha. A lot of descriptions and various uses regarding this plant are available in our Vedic literature, Nighantu and Samhitas since long years ago. It
is a perennial herb about 0.33 to 1meter tall. It is found throughout India. It grows gregariously in aquatic and
sub-aquatic regions. So, it is named Musta. It has been explained in our classical text that a single drug has a potent ability to cure multiple diseases. This article provides a review on medicinal uses and various properties of
Cyperus rotundus. Musta is used to treat several maladies like fever, digestive system disorders, dysmenorrhea,
Lipid disorder. Hence, we can say that it is one of the potential medicinal plants mentioned in our classics. Musta
having several pharmacological actions likes anti-inflammatory, anti-spasmodic, anti-emetic, anti-pyretic, analgesic, carminative and also having hypolipidaemic activity.
SAMSKARAH KARANAM MATAM WSR TO RASAPARPATI
Authors: Mohantyc Bishnupriya , Anilkumar Gosalia Jainam , Keshari Das Sangram
Published: November 2023

Rasa Parpati is the type of Sagandha Parpati Kalpana. To prepare Parpati Kalpana, at least one ingredient should
get liquefied at normal Heating and should get solidified when it gets cooled down, not only that, to get the thin
flake Like structure specific pressure needs to be applied. In the present study Rasa Parpati was Prepared by using Samaguna Kajjali (equal quantity of Parada and Gandhaka) and to check the Cooling effect and the role of
base platform; here three different platforms were made i.e., cow Dung and wet clay mixed platform, only wet
clay platform (Earthen platform) and ice block Platform. Total nine samples of Rasa Parpati were prepared, three
on each platform to check Which platform is convenient to prepare Rasa Parpati. The average thickness of Rasa
Parpati Was found to be minimum (2.83mm) on cow dung and wet clay mixed platform whereas the Maximum
(4mm) on ice block platform i.e., 4mm. Average thickness of Rasa Parpati made on Earthen platform was
3.57mm which is thicker than the Cow dung and wet clay mixed Platform and thinner than the ice cube platform.
Which indicates the best platform to make Thinnest Parpati is cow dung and wet clay mixed platform.
CONCEPT OF HYPERTENSION IN AYURVEDA AND ITS MANAGEMENT
Authors: Kaggod Suma
Published: November 2023

Hypertension is one of the major causes of disability and death all over the world. Hypertension without specific
symptoms in its mild and moderate stages cannot be considered as a disease in Ayurveda. It appears to be an early
stage of pathogenesis and a risk factor for the development of diseases affecting the heart, brain, kidneys eyes etc.
Improper food habits and a modern sedentary lifestyle with or without genetic predisposition provoke and vitiate
all the Tridoshas to trigger the pathogenesis of hypertension. It is proposed that hypertension is to be understood
as the Prasara-Avastha which means the spread of vitiated Doshas from their specific sites. The Avarana(occlusion of normal functioning) of Vata Dosha by Pitta and Kapha can be seen in the Rasa-Rakta Dhathus,
which in turn hampers the functioning of the respective Srotas(micro-channels) of circulation, which can be treated with Shamana, Shodhana and stress-induced cases treated with Medhya Rasayana.
Computational study on the interactions of quercetin 3-O-rutinoside with human DPP III
Authors:   Josip Juraj Strossmayer University of Osijek, Faculty of Agrobiotechnical Sciences, Croatia, Agić Dejan , Bešlo Drago ,   Josip Juraj Strossmayer University of Osijek, Faculty of Agrobiotechnical Sciences, Croatia, Lučić Bono ,   Ruđer Bošković Institute, NMR Center, Croatia, Tomić Sanja ,   Ruđer Bošković Institute, Division of Organic Chemistry and Biochemistry, Croatia, Blagojević Bojana ,   University of Novi Sad, Faculty of Agriculture, Department of Field and Vegetable Crops, Chemistry & Biochemistry Laboratory, Serbia, Popović Boris M. ,   University of Novi Sad, Faculty of Agriculture, Department of Field and Vegetable Crops, Chemistry & Biochemistry Laboratory, Serbia
Published: November 2023

Human dipeptidyl peptidase III (hDPP III) is a zinc-dependent enzyme that participates in several pathophysiological processes. Recently, we have shown that Prunus fruit extracts have the potential to inhibit hDPP III and that its flavonol component, quercetin 3-O-rutinoside (Q3r), has the affinity to bind into the active site of the open form of hDPP III. In this study, docking and molecular dynamic (MD) simulations were performed to investigate the possible interactions between Q3r and the semi-closed form of hDPP III, a more common form in water. The docking results have shown that Q3r has a better binding affinity to the semi-closed form of hDPP III compared to its open form. Results of the MD simulations showed seven H-bonds, as well as several van der Waals and π interactions between Q3r and hDPP III active site residues. This computational study provided valuable insight into how this flavonol compound interacts with hDPP III and supports its observed in vitro inhibitory activity.
Repulsive water-water contacts from Cambridge Structural Database
Authors:   Innovative center of the Faculty of Chemistry in Belgrade, Serbia, Milovanović Milan R. , Živković Jelena M. ,   Innovative center of the Faculty of Chemistry in Belgrade, Serbia, Stanković Ivana M. ,   University of Belgrade, Institute of Chemistry, Technology and Metallurgy, Serbia, Ninković Dragan B. ,   Innovative center of the Faculty of Chemistry in Belgrade, Serbia, Zarić Snežana D. ,   University of Belgrade, Faculty of Chemistry, Serbia
Published: November 2023

Water is one of the most important molecules on the Earth. Since water plays a crucial role in many life processes, it is of great importance to understand every aspect of its behavior and interactions with itself and its surroundings. It is known that water molecules can interact via classical hydrogen bonds and antiparallel interactions, with interaction energies of – 5.02 kcal/mol and -4.22 kcal/mol, respectively. Besides these attractive interactions, repulsive interactions were also noticed. In this work, we analyzed repulsive water-water contacts from the Cambridge Structural Database. All interaction energies were calculated at the so- called gold standard, i.e., CCSD(T)/CBS level of theory. It was found that among all water-water contacts, ca. 20% (2035 contacts) are repulsive with interaction energies mainly up to 2 kcal/mol. Most of these repulsive contacts do not belong to two main groups of water-water contacts. Namely, 12.8% of all repulsive contacts can be classified as classical hydrogen bonds, 2.1% to the antiparallel interactions, and the rest (85.3%) as remaining contacts. This study points out that additional attention should be paid when one deals with contacts including water or, eventually, hydrogen atoms in general.
Strategies and Forms of Communication Writing The Novel "Cold Baby” By Witzlu on The Online Novel Digital Platform
Authors: Sriningsih Sriningsih
Published: November 2023

This research explores the strategies and forms of communication employed in the creation of the novel "Cold Baby" by Witzlu on the online digital novel platform. Language plays a crucial role in human communication, and the written language is a significant medium for conveying ideas and information. Writing skills, particularly in literature, are essential but often lack adequate publication and promotional strategies, hindering the writer's impact. Effective novel writing strategies encompass understanding the target audience, selecting a unique genre, choosing a compelling plot, crafting strong characters, creating engaging conflicts, using narrative techniques, employing dialogue effectively, and varying language styles. In the digital age, writers have embraced online platforms for publishing and promoting their works, reaching a wide readership and contributing to the growth of Indonesian literature in digital form. The research aims to shed light on these strategies, inspiring aspiring writers to create quality digital literature and enrich Indonesia's literary heritage.