bluuebunny/crossref_metadata_2025 huggingface dataset:
ЛЮДСЬКА ГІДНІСТЬ ЯК ЧИННИК ЄВРОІНТЕГРАЦІЙНИХ ПРОЦЕСІВ УКРАЇНИ ТА ЇЇ РЕЛІГІЙНО-ДОКТРИНАЛЬНЕ ОСМИСЛЕННЯ
Authors: КУЛАГІНА-СТАДНІЧЕНКО Ганна
Published: November 2022

Метою статті постає з’ясування пріоритетних концепцій, богословських підходів християнських церков України до проблеми людської гідності з огляду на сучасні євроінтеграційні процеси української держави. Методологічними засадами дослідження стали компаративний аналіз, контент-аналіз, діалектика, культурологічний та антропологічний принципи, а також принципи об’єктивності, правового забезпечення релігійної свободи як свободи совісті. Наукова новизна. Звернення до проблеми людської гідності під час історичних випробувань України не лише включає Церкву до широкого спектру реальних взаємовідносин з державою, але й робить важливим актором євроінтеграційних процесів. Кожному етапу суспільно-історичного розвитку європейської інтеграції України властиві різні прояви релігійної активності церков, їхня різноманітна реакція на антропологічні, етичні виклики соціального середовища. Сучасні євроінтеграційні процеси України надто актуалізують роль людського чинника не лише у підтримці української ідентичності, але й у збереженні гуманістичних, загальноцивілізаційних цінностей світового співтовариства. У цьому аспекті проблема гідності має сенсожиттєвий вимір, вказує на подальшу життєспроможність держави та церков у ній, постає гуманістичним осердям, центром європейських цивілізаційних норм та принципів. Від того, як українські церкви відповідатимуть на цей виклик, надто залежить їх майбуття в українській державі можливість мирного співіснування у спільному європейському просторі. Отже, авторка пропонує компаративний аналіз сучасних відповідей християнських церков України на питання про людську гідність. У висновках підкреслюється, що в умовах війни, яка ведеться Росією на території України всупереч будь-яким гуманістичним та цивілізаційним нормам європейського співтовариства, толерування держави-агресора не видається можливим, оскільки означає нехтування загальнохристиянськими цінностями на догоду позиції Російської Православної Церкви. Релігійним організаціям вже недоречно залишатися у статус-кво із закликом «Мир цінніше за свободу». Церкви повинні враховувати громадський простір, незважаючи на те, що за наявності лівих партій при владі деяких держав світового співтовариства маємо нову розстановку сил, коли лібералізм вимагає змін без особливих заворушень, прагне не виходити за межі досягнутої зони комфорту. Церквам слід навчитися називати речі власними іменами, позбутися позиції, коли вони не бажають критикувати одна одну, піднімати важливі еклезіологічні та політичні теми. В умовах війни, яку розв’язала Росія в Україні за активної підтримки Російської Православної Церкви, не може бути діалогу в контексті примирення з агресором. Нині «холодна війна» вже перейшла у фазу загрози Європі та світу ядерною катастрофою з боку Російської Федерації, отже, ідея міжрелігійного діалогу потребує нагального реконструювання, вимагає прямої відповіді на питання про те, чи діалог може бути місією Церкви, вестися нею ціною істини та потурати людську гідність.
Assessment Ideas For Fostering Online Learning Autonomy
Authors: Rambe Sokhira Linda Vinde
Published: November 2022

Learning autonomy means learners have to take responsibility in handing their own learning with the help and supervision guided by teachers. Then, selecting types of assessment techniques can be a way to create students’ learning autonomy during the instructional process. Thus, the objective of this study is to determine some techniques of English learning assessment that can foster students’ learning autonomy in online learning environment. Qualitative research was applied as research design done at English Education Department of the Institute for Islamic Studies of Padangsidimpuan. Ten lecturers of English Education Department were chosen purposively as respondents and interview was used as data collection technique. Then, the data were analyzed through qualitative data analysis in which the data were described and elaborated in detail ways. Related to findings, this study found some techniques of English learning assessment that regarded effective to improve students’ independence in online learning i.e. portfolio assessment, discussion and problem solving, essays and summary writing, online presentation, multimedia presentation, mini research, and recording performance task. Finally, this study concluded that there are many assessment techniques to foster students’ online learning autonomy and the promotion of learning autonomy becomes an important aspect to be included in online learning environment.
The Students’ Mastery in Subordinating Conjunction
Authors: Hasibuan Risdayanti , Lubis Fitriadi
Published: November 2022

This research is discussing about students’ ability in mastering subordinating conjunction. The aim of this research was to find out the student’ ability in mastering subordinating conjunction at the fourth semester students of English Department IAIN Padangsidimpuan. This research was descriptive quantitative method that was conducted at the fourth semester IAIN Padangsidimpuan. The population of this research was fourth semester students of English department IAIN Padangsidimpuan. This research used 21 students as a sample. They were gotten by random sampling technique. The mean score of the students’ ability in mastering subordinating conjunction was 81.93. The result of this research showed the students ability in mastering subordinating conjunction was very good category.
Video-making Projects for TPACK Development of Pre-service EFL Teachers
Authors: Yonata Fadhila , Sandra Heris , Serly Serly , Ortapia Nefya , Sari Lasri Novita
Published: November 2022

This study examines the impact of the video-making project assigned for pre-service teachers in English education department to enhance their competences of TPACK. Anchored in a qualitative approach, semi-structured interview with six student teachers in second semester was conducted to gain their voices on whether producing video as part of tasks in two English subjects facilitated them on learning new insight related to technology, pedagogy and content of some materials. Findings reveal video-making projects promoted self-eagerness to improve self-competence and collaboration with peers and lecturers. Consequently, making a video as tasks showed a potential for developing pre-service teachers’ TPACK. Participants’ voices indicated there were some challenges in video producing process. The study also suggests that there is ample room for improvement especially in preparing student teachers with prior knowledge of using technology.
Students’ Preferences on Online-Based Media for Writing Course and the Reasons
Authors: Wahyunengsih Wahyunengsih , Arum Dewi Sekar , Jannah Miftakhul , Irtiyah Nuraffah , Anggraeni Siska , Sari Avita Ayu Permana
Published: November 2022

This article aims to investigate students’ point of view about the most preference on online writing course media and their reasons. The methodology used was qualitative research method. The instrument was the questionnaires that were given to 34 students of Writing Course. They were in the fourth semester majoring in English Teaching. The finding showed the various type of applications and digital technology for learning in synchronous class such as, zoom, Google meet, Facebook, and Whatsapp Chat video. The Social media and translation machines take place as the most preferable online media for writing course. In choosing learning media, teachers must consider the learners’ previous knowledge related to technological skills as well as the practicality of the media. There are plenty of sophisticated online media of writing nowadays, but without having a good research on students’ preferences, it will be worthless.
The Use of Animation Video for Vocabulary Mastery
Authors: Hikmah Sofia Datun
Published: November 2022

This study discussed an important aspect in learning English, namely the vocabulary. The teachers must have an easy, practical and interesting way to teach the vocabulary. Animated videos are considered as the right medium and very useful for teaching. This research focused on the effective use of animated cartoon videos and increasing the use of animated videos in improving the students’ learning mastery at grade IIV of Mayang 01 Junior High School. The purpose of the study was to determine the effectiveness and significance of the implementation or not using the technique itself. This research was quantitative. The method used in this research was by using test to collect instruments in collecting data. From the results of the research, it can be concluded that the students really like learning by using animated videos or cartoons. The respondents also are very positive about this media and students became more active in learning English. In conclusion, the use of video can be applied to all students.
Interpersonal Meaning Realized in the Conversation Texts in English Textbook for Senior High School
Authors: Harahap Eni Fauziah
Published: November 2022

This research examines the interpersonal meaning realized in the conversation texts in English Textbook for Senior High School Grade X. The purpose of this research is to describe the interpersonal meaning realized in the conversation texts in English Textbook. The interpersonal meaning that is analyzed namely the most dominant mood elements, residue elements and modality types. The design of the research was descriptive qualitative. The main sources of data in this research were the conversation texts realized in the English textbook. There were 58 conversation texts and 400 clauses gotten from those 58 texts that the researcher analyzed in this study. The results of data analysis showed that the interpersonal meaning realized in the conversation text: the most dominant Mood Types was declarative (298 clauses), then interrogative (94 clauses) and the least was imperative (11 clauses). While, the most dominant residue elements was complements are the highest dominant (329 clauses), then followed by predicators (246 clauses), the last was adjuncts (94).
Students’ Application of Systematic Functional Linguistics on EFLs’ Blog Website
Authors: Hutasuhut Seriani , Harahap Octa Vina
Published: November 2022

The study aims to investigate the Systemic Functional Linguistics (SFL) as a method for analyzing text. The Systemic Functional Linguistics (SFL) has a nearly limitless range of applications. Social media has become an important platform for everyone to broadcast information, opinions, and emotion freely and borderless in today's society especially on blog. Using a qualitative method, this research focused on the outcome of the students’ ability in applying SFL on social media. The data are taken from Blog-Web media of English Education Department Students IAIN Padangsidimpuan. The findings lead to the conclusion that the application of Systemic Functional Linguistics on Blog was good. Interpersonal meaning occurred in 9 times or in percentages of 45% of written clauses entires. It signifies that its ability to inform and persuade readers goes optimal. However, linguistic approaches must be improved in order for the texts to sound more understandable.
THE APPLICATION OF GOOGLE CLASSROOM IN LEARNING ENGLISH: STUDENTS’ INTERESTS
Authors: Nasution Puspita Sari , Dewi Utami
Published: November 2022

This study aimed to describe students’ interests in the application of Google Classroom (GC) in learning English. The subjects of this study were ten students of the Religious Department who learn English subject. The instruments of data collection were questionnaires and interviews. The data were analyzed by using the theory of Miles and Huberman. The results showed that students’ interest in learning by using online through Google classroom has four aspects include: (1) The students felt happy in learning English using Google Classroom was 60 %; (2) The students had a strong interest in using Google classroom in learning English was 50%; (3) The students gave strong attention in the process of using Google classroom was 40%; and (4) The students actively involved in using google classroom was 50%.
Simple Linear Regression Method to Predict Cooking Oil Prices in the Time of Covid-19
Authors: Hasibuan Lilis Harianti , Putri Darvi Mailisa , Jannah Miftahul
Published: November 2022

The background of this research is the soaring price of cooking oil during the Covid-19 period which continues to increase in the city of Padang. The research method used is a case study of data on cooking oil prices in the city of Padang. The purpose of this study is to obtain predictions of cooking oil prices. Linear regression is used as a prediction method for cooking oil prices in the next X(t) period. The research method used is a case study using simple linear regression. In this study, the actual cooking oil price Y(t) is the effect variable and the time period is the causal variable. The linear regression equation obtained is Y'=25239+124.56X. Testing the accuracy of the prediction results using RMSE with a value of 0.1913. The prediction of cooking oil prices using the linear regression method can be said to be in the very good category, it can be seen that the RMSE value is very small in the test and meets the standards.
Minat Belajar Matematika pada Siswa SMP Negeri 7 Padangsidimpuan
Authors: Siregar Nur Fauziah
Published: November 2022

This study aims to determine the condition of class VII students' interest in learning mathematics at SMP Negeri 7 Padangsidimpuan. This research was conducted using a survey method. The population in this study were all students of class VII. As for the sample in this study were 26 students who were taken from the population with a sampling technique in accordance with the proportions. The instrument used was a learning interest questionnaire. Interest in learning questionnaires distributed to a sample of 20 items. The questionnaire that is distributed to the sample is a valid questionnaire. The results of this study indicate that the seventh grade students of SMP Negeri 7 Padangsidimpuan have moderate learning interest in mathematics.
Pengaruh Konsep Diri dan Kemandirian Belajar terhadap Hasil Belajar Matematika Siswa SMP
Authors: Astuti Liana Widya , Pujiastuti Heni
Published: November 2022

This research aims to see how much influence self-concept and learning independence have on mathematics learning outcomes. The method used is a survey method with a quantitative approach. The sample in this study were students of Class VIII B MTs. Daar El-Huda as many as 32 students. Data collection is done by giving a questionnaire. The data used are primary data and secondary data. Primary data includes 2 variables (self-concept and learning independence) which were collected with previously validated instruments. Secondary data is the result of students' mathematics learning obtained from mathematics teachers. Based on the results of the study, it can be concluded that first, there is an effect of self-concept and independent learning together on learning outcomes of mathematics. The contribution of self-concept and learning independence to mathematics learning outcomes is 96.1% and the remaining 3.9% are other variables that contribute besides self-concept and learning independence. Second, there is the effect of self-concept on mathematics learning outcomes. Third, there is the influence of independent learning on mathematics learning outcomes.
Deskripsi Pengembangan Keprofesian Berkelanjutan Guru Matematika
Authors: Rangkuti Ahmad Nizar , Sari Roimah
Published: November 2022

The purpose of this study was to describe the continuous professional development of mathematics teachers at SMPN 6 Panyabungan which includes aspects of self-development, scientific publications, and innovation works. The data collection method used consisted of observation, interviews, and document studies. Data analysis used descriptive qualitative analysis method which aims to describe how the continuous professional development of mathematics teachers at SMP Negeri 6 Panyabungan and how to deal with problems faced in carrying out continuous professional development of mathematics teachers. The results of the study concluded that in carrying out the Continuing Professional Development (PKB) mathematics teachers there were several problems, namely the lack of a given quota, ignorance of Continuing Professional Development (PKB) and the lack of a teacher's intention to participate in Continuing Professional Development (PKB).
FIGUR PENDIDIK HUMANIS DI MASA PANDEMI COVID 19
Authors: Asfiati Asfiati , Pulungan Ihwanuddin
Published: November 2022

The Covid 19 pandemic has shifted the learning process, which was originally running in real terms, now to the virtual world. All hopes that the Covid 19 pandemic period is used to create added value in seeing humans based on moral values (ethics) of religious humanism (religious humanism). Likewise, emulating humanist educator figures during the Covid 19 pandemic. Humanist educators guide students to think positively. Learning that is faced with many applications, via Facebook, Youtube, IG, WA, Line, Zoom, Microsoft Team, Google Classroom, or communication via teleconference seems to give rise to creativity. Humanist educators present their respective roles well so that learning becomes fun and still results in progress.
MEMPELAJARI PERILAKU BAHASA PEDAGANG ANGKOLA DALAM MENGUNGKAPKAN PROSES EKSISTENSIAL
Authors: Pulungan Husniah Ramadhani
Published: November 2022

Tujuan utama dari penelitian ini adalah untuk mendeskripsikan perilaku bahasa pedagang Angkola dalam mengungkap proses eksistensialnya. Mengingat pedagang adalah orang-orang yang sangat sibuk dan sangat menghargai waktu, di sini akan diungkap bagaimana pedagang mengedepankan eksistensi terhadap sesuatu secara lisan. Penelitian ini menawarkan agar studi kasus ini dapat dianalisis dengan menggunakan pendekatan Systemic Functional Linguistics (SFL). Datanya diperoleh dari dua belas pedagang Angkola, enam orang laki-laki dan enam orang perempuan, melalui wawancara yang ditranskrip dan dianalisis dengan analisis transitivitas. Temuannya berupa pola proses eksistensial yang ditemukan adalah pola standar (proses + eksisten) beserta pola variannya, pola inversi (eksisten + proses) beserta pola variannya, dan pola proses (eksistennya lesap atau morfem zero (ø)). Selanjutnya, proses yang muncul adalah adong 'ada' dan nadong 'tidak ada' beserta variannya. Tidak ditemukan data yang menunjukkan adalanya terdapat dan muncul sebagai penanda lain dari proses eksistensial. Lebih lanjut lagi, pengalaman eksistensi dan non-eksistensi pedagang dapat terungkap dari jumlah konstituen proses yang muncul beserta pilihan diksi yang digunakan. Semoga, hasil penelitian ini dapat menambah kerangka teoretis dalam mengenali ciri-ciri karakter pedagang di bidang ekonomi dan juga pengayaan teoretis SFL sebagai pendekatan yang dapat mengungkapkan pola bahasa di berbagai bidang.
MANAJEMEN PEMBELAJARAN DALAM PEMBINAAN AKHLAK SISWA DI MADRASAH TSANAWIYAH AL-MAIDAR PANDAN
Authors: Siregar Lis Yulianti
Published: November 2022

This research conducted in  Madrasah  Tsanawiyah Al-Maidar Pandan. The results of the study  are  as  follows: The character of morality in Madrasah Tsanawiyah Al-Maidar Pandan consists of three stages, namely: planning, implementation and evaluation of learning in moral character building. Planning  is  done  by  preparing the instructional administration early in the school year. Implementation of moral coaching using several strategies, methods in the delivery of learning materials. Other efforts are made in the following ways: a) Familiarize 5 S (Smile, Sapa, Greetings, Sharing, Polite Eid), b) Read the Qur'an    on Friday, c) Good relationship with parents. d) Through exemplary, advice or motivation and education through punishment. e) Good communication to students. f) Creating a religious atmosphere. Evaluation used to measure the success of moral coaching students is the assessment in writing in the form of report cards and also the assessment in the form of words through the three domains of cognitive, affective and psychomotor domains
TINJAUAN BATASAN TOLERANSI ANTAR UMAT BERAGAMA DALAM PERSPEKTIF ISLAM
Authors: Mahmud Muhammad
Published: November 2022

This article aims to introduce more deeply about the limits of religious tolerance in an Islamic perspective. This research method is library research. The analysis used in this research is to use descriptive analysis. The data is classified and then adjusted according to the study in sequence. For this reason, researchers use books or journals and research results relating to this article. The results of this study indicate that, in the view of Islam, the limit of tolerance is that humans are social beings who are of course required to interact with other individuals, even Islam provides a clear domain. Included in interacting is of course still prioritizing respectful prices, not dropping each other, remaining within the corridor limits stipulated in the Islamic religious law.
TRADISI PENDIDIKAN MADRASAH
Authors: Mesini Mesini -
Published: November 2022

Abstract This paper aims to examine the tradition of madrassas both in the historical context of their establishment, in Indonesia, the modernity of madrasas, the opportunities and challenges of madrasas in the Covid-19 Era. This research is library research by analyzing the madrasah concept descriptively. To facilitate this research, the researcher collected books and articles that lead to madrasas. Next, check and provide an analysis of the book. The results of this research indicate that the tradition of madrasa education is an important part to be traced continuously. Madrasas have dynamics such as opportunities and challenges that must be faced optimistically during the Covid-19 pandemic. Also, the development of madrasas cannot be separated from the study of traditions. Starting from history, its development to the opportunities and challenges.   Abstrak Tulisan ini bertujuan untuk meneliti tradisi madrasah baik dalam konteks sejarah berdirinya, di Indoonesia, kemoderenan madrasah, peluang dan tantangan Madrasah di Era Covid-19. Penelitian ini merupakan penelitian pustaka dengan menganalisis konsep madrasah secara deskriptif. Dalam mempermudah penelitian ini peneliti melakukan pengumpulan buku-buku dan artikel yang mengarah pada madrasah. Selanjutnya dilakukan pengecekan dan memberikan analsisi terhadap buku tersebut. Hasil penelitian ini menunjukkan bahwa tradisi pendidikan madrasah merupakan bahagian penting yang untuk ditelusuri secara terus menerus. Madrasah memiliki dinamika seperti peluang dan tantangan yang harus dihadapi dengan optimis di masa pandemi covid-19. Selain itu, perkembangan madrasah tidak bisa dilepaskan dari kajian tradisinya. Mulai dari sejarah, perkembangannya hingga peluang dan tantangannya.
Control constitucional del Estado de excepción y los decretos expedidos en Colombia durante el año 2020 con ocurrencia del Covid-19 y la vulneración de derechos fundamentales
Authors: Castro Hernández María Alejandra
Published: November 2022

En este artículo de investigación se aborda el tema relacionado con la declaratoria del Estado de Emergencia Económica, Social y Ecológica y los Decretos Legislativos expedidos en Colombia en el año 2020 debido a la pandemia ocasionada por el Covid-19. Frente a dicha situación, la Corte Constitucional ejerció control previo y automático de 115 Decretos Legislativos expedidos durante el Estado de Excepción y declaró numerosas inexequibilidades. Como objetivo principal del artículo, se encuentra el análisis de las sentencias de la Corte Constitucional por medio de las cuales se revisan los 115 Decretos Legislativos, para determinar la existencia de vulneración de Derechos Fundamentales. Este artículo se desarrolló bajo un enfoque analítico-descriptivo, pues se detallan las características de los Estados de Emergencia; se menciona la forma en que la Corte ejerce control constitucional (formal y material); y se analiza de forma detallada toda la jurisprudencia de la Corte mediante la cual se ejerce control constitucional. Todo lo anterior se realiza, para finalmente llegar a la conclusión de que efectivamente algunos de los Decretos Legislativos vulneraron derechos fundamentales como el derecho a la cultura, a la identidad nacional, a la igualdad, al trabajo, entre otros.
A diabetes mellitus szűrési és kezelési tendenciáinak vizsgálata általános kardiológiai betegekben
Authors: Pintér Jenő Antal , Csuport Tibor , Farkas Attila , Saddik Jdid Mahmoud , Csadi Róbert , Farkas András
Published: November 2022

Bevezetés: A diabetes mellitus (DM) és a kardiovaszkuláris betegségek kapcsolata régóta ismert. Sajnos a kardiológiai ellátásban gyakran háttérbe szorul a DM követése, esetenként diagnosztizálatlan marad, ami kiemelt kockázatot jelent a kardiológiai betegekre. Célul tűztük ki az osztályunkon kezelt kardiológiai betegek körében felmérni a DM előfordulását, szűrési, kezelési tendenciáit. Módszerek: 324 általános kardiológiai beteg adatait vizsgáltuk retrospektíven; a betegeket a Szegedi Tudományegyetem II. sz. Belgyógyászati Klinika és Kardiológia Központ Kardiológiai Osztályán 2019. január 1. és 2019. december 31. között kezeltük. Eredmények: Felvételkor a betegek 34%-áról volt ismert a szénhidrátanyagcsere-zavar, ezen betegek 87%-ánál történt DM-kontrollvizsgálat: az esetek 42%-ában a HbA1c-érték meghaladta a 7,0%-os szintet. A betegek 54%-ának módosítottuk a terápiáját; szulfonilurea-terápiában részesülő betegek aránya felvételkor 28%, kezelésmódosítás után 19% (p<0,05); SGLT2-gátló terápiában részesülő betegek aránya felvételkor 9,5%, kezelésmódosítás után 20% (p<0,05). A felvételkor ismert szénhidrátanyagcsere-zavarral nem rendelkező betegek 76%-ának végeztünk DM-szűrővizsgálatot. A DM-szűrővizsgálatok 55%-a igazolt szénhidrátanyagcsere-zavart, 42%-ban preDM igazolódott, 13%- ban DM-diagnózis született. Összességében a felvett betegek 62%-áról vált ismertté, hogy szénhidrátanyagcsere-zavarban szenved. Következtetések: Az ismert diabéteszes betegek jelentős részének nem volt kellően hatékony a diabetológiai kezelése kardiológiai osztályunkra történő felvételük előtt, terápiájukat gyakran módosítani kellett, korszerűbb antidiabetikumokra kellett váltanunk. Eredményeink alapján nagy a felderítetlen szénhidrátanyagcsere-zavarral élő betegek aránya a kardiológiai betegek körében. Vizsgálatunkban a kardiológiai betegek közel kétharmada szenvedett valamilyen szénhidrátanyagcsere-zavarban. A kardiológiai betegek diabetológiai szűrését, antidiabetikus kezelését, és a kardiometabolikus szemléletet részévé kell tenni a mindennapi kardiológiai betegellátásnak.
Szívinfarktuson átesett személyek és kontrollcsoport protektív pszichológiai tényezőinek vizsgálata
Authors: Rafael Beatrix , Pongó Zsófia
Published: November 2022

Bevezetés: Számos kutatásban vizsgálták már a negatív érzelmek egészségre gyakorolt hatását, azonban a pozitív pszichológiai tényezők egészségügyi hatásait jóval kevesebben elemezték. Az eddigi eredmények arra utalnak, hogy a pozitív pszichológiai tényezők független módon kapcsolódnak a kardiovaszkuláris előnyökhöz, túl a negatív állapotok egyszerű hiányán. Célkitűzés: Pilot vizsgálatunkban szívinfarktuson átesett személyek és egészséges kontrollszemélyek mintáján elemeztük az élettel való elégedettség, a pszichológiai jóllét, a társas támogatás, és a reziliencia szintjét, összehasonlítva a rizikótényezők közül a stressz-szel és a szorongással. A mintában összesen 60 fő vett részt, csoportonként 30-30 fő (átlagéletkor: 55 év). A betegcsoport papír-ceruza formában, a kontrollcsoport online töltötte ki a kérdőíveket. Eredmények: Az élettel való elégedettség, a pszichológiai jóllét és a multidimenzionális társas támogatás barátok alskálája esetében a szívbetegek alacsonyabb értéket mutattak a kontrollcsoporthoz viszonyítva. A társas támogatás mértéke mindkét vizsgálati csoportban negatív kapcsolatban állt a szorongással és az észlelt stressz-szinttel. Következtetés: Kutatásunk eredményei felhívják a figyelmet a protektív pszichológiai tényezők vizsgálatának fontosságára egészséges személyek és a szívbetegek körében egyaránt.
Lipoprotein(a), a „rettenetes lipid”: bemutatok egy családot
Authors: Kiss Róbert Gábor
Published: November 2022

A magas lipoprotein(a)-szint egy örökletes, független kardiovaszkuláris kockázati tényező. Szemben egyéb lipideltérésekkel, a lipoprotein(a)-szintet életmódi változtatások nem befolyásolják. Az ezt a genetikai eltérést hordozó személyek felismerése mégis fontos: közöttük a kezdődő ateroszklerózis időben felismerendő; az egyéb, módosítható kockázati tényezőkre (LDL-koleszterin, dohányzás stb.) tevődő kiemelt figyelem lassíthatja a betegség romlását. Egy elénk kerülő probandus családfavizsgálata egyszerű módja az ezzel az abnormalitással élők megtalálásának. Esetismertetésünk egy ilyen eltéréssel élő család bemutatását tartalmazza.
A Lewis-elvezetés használata
Authors: Simon András
Published: November 2022

„Bemutatok egy EKG-t” címmel régi rovatot indítunk újra a Cardiologia Hungarica hasábjain Munkacsoportunk gondozásában. Olvasóink egy része talán még emlékszik az újság e méltán népszerű rovatára. Célja a látványos, tancélos, akár ritkaságszámba menő EKG-esetek játékos, kvízszerű megjelenítése, az EKG-elemzésben való jártasság előmozdítása. Amennyiben a tisztelt olvasó arra érdemesnek tartott, érdekes és izgalmas saját EKG-görbéket szeretne bemutatni, ne késlekedjen azokat az ekg.megfejtes@gmail.com email címre elküldeni!
Az automata, négy végtagi vérnyomásmérő készülékek szerepe a perifériás verőérbetegség szűrésében
Authors: Fendrik Krisztina , Biró Katalin , Endrei Dóra , Koltai Katalin , Tóth Kálmán , Késmárky Gábor
Published: November 2022

A perifériás verőérbetegség (PAD) leggyakrabban az alsó végtagokat érintő progresszív ateroszklerotikus betegség. Magas prevalenciája ellenére igen gyakran csak elkésve, már a kritikus végtagiszkémia stádiumában kerül felismerésre. Az irányelvek által elfogadott, elsőként elvégzendő noninvazív vizsgálómódszer a PAD diagnosztizálására a Doppler-készülék és manuális vérnyomásmérő segítségével végzett boka-kar index (BKI) meghatározása. A vizsgálat költséghatékony, széles körben elérhető, de a vizsgáló részéről jártasságot és időbefektetést igényel. A speciálisan BKI-meghatározásra kifejlesztett automata, négy végtagi vérnyomásmérő készülékek pletizmográfiás vagy oszcillometriás elven működnek. Használatuk nem igényel különösebb szakképzettséget, a BKI-méréshez szükséges idő közel a felére rövidíthető velük. Hátrányuk, hogy szenzitivitásuk a Doppler-módszerhez viszonyítva alacsonyabb, illetve pontos PAD-diagnosztikára nem alkalmasak, mivel alacsony bokanyomásnál nem végeznek pontos méréseket. Több tanulmány 1,0 körüli automata BKI-határérték használatát javasolta a szenzitivitás növelésére. Fontos szerep juthat az automatákon elérhető kiegészítő funkcióknak (például lábujj-kar index meghatározás, pulzushullám terjedési sebesség mérése), amelyek növelik az érzékenységet a PAD felismerésében. Összességében a metaanalízisek tanulsága szerint a szakellátásban pontos diagnosztikára nem javasolt az automata készülékek használata, ugyanakkor az alapellátásban és szűrőprogramok keretében létjogosultsága lehet a használatuknak. A hazai érbetegellátás javítására széles körű használatuk mindenképpen megfontolandó lenne.
Vitamin E-loaded polymeric nanoparticles from biocompatible adipate-based copolymer obtained using the nanoprecipitation method
Authors: Sokołowska Martyna , Marchwiana Maja , El Fray Miroslawa
Published: November 2022

Despite the search for new biomaterials dedicated for biomedical applications intensified in recent decades, this field is still not fully explored. Therefore, the synthesis of novel aliphatic biopolyesters poly(butylene adipate-co-dilinoleic adipate) (PBA-DLA) was performed using monomers derived from natural sources and enzyme lipase B Candida antarctica (CALB) as biocatalyst in order to provide fully biobased and biodegradable material suitable for drug delivery systems. Proton nuclear magnetic spectroscopy (1H NMR) analysis confirmed chemical structure of PBA-DLA copolyester whereas in vitro cytotoxicity assay indicate on material biocompatibility. By applying a single-step nanoprecipitation method narrowly distributed PBA-DLA nanoparticles (NPs) with hydrodynamic diameter (HD) of ~200 nm were produced, however, after purification (centrifugation) step NPs tend to agglomerate. In order to eliminate this drawback suitable amount of stabilizer (Pluronic F127, 0.05 mg/ml) was selected and NPs with HD of ~149 nm were obtained. The PBA-DLA NPs could be loaded with the hydrophobic α-tocopherol (α-TP) – main ingredient of vitamin E, with encapsulation efficiency ranging from 48 to 74 % depending on tested α-TP concentration (2.5, 5, 10 mg/ml) as evidenced by combined dynamic light scattering (DLS), ultraviolet-visible spectroscopy (UV-VIS) and 1H NMR measurements.
A demand response strategy for air compressors network with optimal production and energy utilisation
Authors: Zulkafli Nur Izyan , Jelas Mohamad Asyraf , Bin Sulaima Mohamad Fani , Bin Sukri Mohammad Firdaus , Bin Mohd Tahir Mustahafah , Hanak Dawid , Kopanos Giorgos
Published: November 2022

The approach of integrating demand response strategy with operational scheduling is used to investigate the flexibility in the operational performance under time-sensitive electricity tariffs and to provide cost benefits analysis to the industrial consumers. The proposed approach focused on implementing a demand response strategy in a case study of scheduling for an industrial network of compressors for Time of Use and Enhanced Time of Use tariffs for heavy industries. The optimisation framework was developed as a mixed integer linear programming model. The percentage of total cost reduction is around 5% to 13% by implementing a demand response program. A considerable percentage of cost saving is possible to achieve for the Enhanced Time of use tariff since it offers an extensive off-peak time zone during the night hours and on the weekend. It is concluded that the study highlights the operational performance goal of achieving cost savings by implementing a demand response strategy for energy industries.
π-Extended Iodoarene as an Electrochemical Mediator for Oxidative C-N Coupling: Reactions, Mechanism, and Kinetics
Authors: Yoshinaga Shohei , Atobe Mahito , Shida Naoki
Published: November 2022

Herein, we present the design and application of π-extended iodoarenes for electrocatalytic C-N bond coupling reac-tions. The extended π-systems of such compounds lower the oxidation potentials and stabilize the radical cation states, thus facilitating the selective and efficient electrochemical generation of hypervalent iodine. The electrocatalytic C-N coupling reactions of various N-protected aminobiphenyl derivatives were achieved, including those of substrates with the tert-butoxycarbonyl protecting group, which has never been applied to electrochemical C-N coupling reactions. A mechanistic study suggests the presence of halogen-bonding interactions of the radical cation state of the iodoarene with Lewis bases, and the coordination of Lewis bases evidently promotes electrochemical oxidation to generate hypervalent iodine species. A kinetic study using foot-of-the-wave analysis (FOWA) was also employed for the first time to examine electrochemical hypervalent iodine catalysis.
Theoretical chemical reaction database construction based on quantum chemistry-aided retrosynthetic analysis
Authors: Harabuchi Yu , Maeda Satoshi
Published: November 2022

A theoretical database comprising experimentally accessible and inaccessible chemical reactions could complement the existing experimental databases and contribute significantly to data-driven chemical reaction discovery. Quantum chemistry-aided retrosynthetic analysis (QCaRA) can generate a network of elementary steps called a reaction-path network and predict hundreds or more of chemical reactions along with their theoretical yields. In contrast to ordinary simulations, QCaRA traces back the reaction paths from the target product to various reactant candidates while solving the kinetic equations. In this study, we propose theoretical reaction database construction based on QCaRA. Seven reaction-path networks containing 13,190 reactions, 108,754 reaction paths, and 2,552,652 geometries have been identified and discussed as examples. In addition to well-known reactions (i.e., synthesis of fluoroglycine, Wöhler’s urea synthesis, base-catalysed aldol reaction, Lewis-acid-catalysed ene reaction, cobalt-catalysed hydroformylation, Strecker reaction, and Passerini reaction), numerous unexplored reactions with high, medium, low, near-zero, or zero yields have been identified. We anticipate that such a QCaRA-based theoretical reaction database will provide information on hitherto unexplored reactivities, especially those that are experimentally inaccessible.
[2.2.2]Urea cryptand: an easily accessible neutral organic cage for anion binding in water
Authors: Wu Xin , Clegg Jack K.
Published: November 2022

Binding hydrophilic anions such as sulfate in water is a significant academic challenge, in particular for neutral receptors. To achieve this, typically a large molecular receptor is designed that wraps around a bound anion in a hydrophobic microenvironment. Such receptors require multi-step synthesis and often display selectivity towards hydrophobic anions such as iodide. We here report the one-pot synthesis of a [2.2.2]urea cryptand (cage) and its ability to bind sulfate in water with sub-millimolar affinity achievable by incorporation into micelles. Unlike existing neutral receptors, the cage has >10-fold selectivity for sulfate against hydrophobic anions even in pure water. The cage displays rare slow-exchange NMR responses to divalent anions in DMSO-water allowing for simultaneous analysis of multiple divalent anions in water analogous to an ion chromatography instrument. Our results demonstrate the pre-organization of strong directional NH hydrogen bond donors in a cage scaffold as a synthetically less-demanding, yet effective approach to achieving selective binding of hydrophilic anions in water.
Radioactive iodine in the treatment of Graves' disease: history and modern concept of radionuclide therapy
Authors: Sheremeta Marina S. , Korchagina Maria O. , Pesheva Ekaterina D. , Fadeev Valentin V.
Published: November 2022

Radioactive iodine 131I is a theranostic isotope used both for diagnosis and therapy of benign thyroid diseases and thyroid cancer for 85 years. The formation of nuclear medicine is closely linked with the use of 131I. The history of radioiodine therapy began in 1941, when endocrinologist Saul Hertz for the first time used 131I to treat patients with Graves' disease. Since 1946 radioactive iodine 131I became widely available, and its effectiveness became public knowledge after reports on thyrotoxicosis treatment published in the Journal of the American Medical Association by multidisciplinary groups of scientists physicists and endocrinologists. In 1951, isotope 131I became the first Food and Drug Administration approved RP for the treatment of thyroid disorders. Around the same time on the basis of the First Moscow Medical Institute studies on the use of radioiodine isotopes in patients with thyrotoxicosis began. The head of the Soviet group on the studying of radioactive iodine was the physician-scientist Vera Georgievna Spesivtseva. The research works of medical physicists Edith Quimby and Leonidas Marinelli in optimizing therapeutic strategies using radioactive substances in the late 1940s and the wording of the ALARA (As Low As Reasonably Achievable) principle of minimizing exposure of ionizing radiation by the International Commission on Radiological Protection in 1954 contributed to the greater introduction of radionuclides into the medicine.
Intermittent fasting: endocrine aspects: A review
Authors: Altashina Marina V. , Ivannikova Ekaterina V. , Troshina Ekaterina A.
Published: November 2022

The increasing number of overweight and obese people makes the search for new effective ways to reduce body weight extremely urgent. Recently, intermittent fasting has received a lot of attention, as a dietary protocol, presumably effective in reducing body weight. Despite the large number of studies, the effects of intermittent fasting on the human body are controversial, since studies differ in dietary options, design, and often have a small sample size. In this review of the literature, the authors cite the results of studies of the effectiveness of intermittent fasting in patients with obesity, diabetes mellitus, and high risks of developing cardiovascular diseases.
New opportunities of antithrombotic therapy in patients with type 2 diabetes mellitus and stable coronary heart disease for reducing the cardiovascular risk and cardiovascular complications: THEMIS, THEMIS-PCI trials
Authors: Kalashnikov Victor I. , Michurova Marina S.
Published: November 2022

Patients with diabetes mellitus (DM) and coronary heart disease belong to a group with a very high risk of developing cardiovascular disease. In patients with coronary atherosclerosis, DM increases the risk of ischemic events by 24 times. Apparently, increased antithrombotic therapy has an advantage in patients with DM who have had myocardial infarction. However, until recently it was not clear there is such an advantage in patients with DM and stable coronary artery disease without prior myocardial infarction. The addition of ticagrelol to monotherapy of acetylsalicylic acid reduces the risk of major cardiovascular events in patients with type 2 DM and stable coronary artery disease undergoing percutaneous coronary intervention, if patients have a high risk of ischemic events.
Prospects of using the nucleoside analogue riamilovir in patients with SARS-CoV-2 infection
Authors: Maltsev Oleg V. , Kasyanenko Kristina V. , Kozlov Konstantin V. , Zhdanov Konstantin V. , Lapikov Igor I.
Published: November 2022

Aim. To evaluate clinical efficacy of nucleoside analogues in therapy of moderate COVID-19 in in-patients.
Materials and methods. Retrospective processing of 108 completed clinical cases with moderate novel coronavirus disease was carried out for the period 20202021. The duration of the disease at the time of admission did not exceed three days. Experimental group consisted of 53 patients who, in addition to standard therapy, were prescribed off-label riamilovir at a daily dosage of 1250 mg for 5 days by the decision of the medical commission. Comparison group included 55 patients who received a combination of umifenovir and ribavirin as antiviral therapy for 5 days. The duration of the main clinical manifestations of the disease, the indicators of clinical and biochemical blood tests, results of the SARS-CoV-2 virus RNA study using the nucleic acid amplification method (NAAT diagnostics).
Results. Significantly faster achievement of clinical improvement in the group of patients treated with riamilovir was shown, as well as faster sanitation from SARS-CoV-2 virus based on the results of etiological testing.
Conclusion. The use of riamilovir for the treatment of patients with moderate novel coronavirus infection (COVID-19) resulted in a significant reduction of general infectious syndromes and respiratory symptoms. Patients from the experimental group significantly faster achieved clinical recovery and sanitation from the pathogen according to the results of NAAT diagnostics.
THE INFLUENCE OF TRUST AND MISTRUST ON INTERNATIONAL RELATIONS
Authors: Batalov Oleksii
Published: November 2022

The influence of trust and mistrust on international relations is considered. The difference between such phenomena as «culture of trust», «culture of mistrust» and «culture of disbelief» is shown. Based on actual examples, it is analyzed how trust-based international relations are formed (special attention is given to whether the states follow written and unwritten “rules of the game”), how trust can be broken down and mistrust can grow, and how trust can be restored in international relations (two ways to restore trust are provided: gradual mutual tension reduction and valuable signals).

Based on the theoretical provisions of the concept of F. Fukuyama, the interrelation between trust and economic development is shown (economically developed countries have a high level of trust both within a society and at international level). Based on P. Sztompka’s theory, it has been proved that truly stable trust-based relations can be formed only between democratic, peaceful, harmonious, and holistic societies.

It has been proved that trust in international relations contributes to an increase in security, economic and cultural development, an increase in the living standards of the population, and reduces the likelihood of armed conflicts. In the aggregate, trust-based relations at the international level form a sustainable world order. It turns out that mistrust brings about chaos in international relations, diminution of the security, arms race, armed conflicts, and the destruction of the world order.
UKRAINE AND SERBIA: A LONG WAY TO EUROPEAN INTEGRATION
Authors: Liuba Оlena
Published: November 2022

The article considers the stages and features of the European integration process in Ukraine and Serbia. It is noted that insurmountable corruption, economic problems, violations of the territorial integrity of these states hinder the successful implementation of reforms. This in turn complicates the way for the countries to obtain EU membership. The reasons and conditions under which the Ukrainian and Serbian states today aspire to join the European Union are analyzed. It is emphasized that peace, security and stability are considered key achievements of European integration on the continent. It is noted that the awareness of their civilizational belonging to Europe, the desire to achieve a European level of social life, the need for security, protection against terrorism, etc. actualize the movement of these states in the proclaimed strategic direction.

At the legislative level, Ukraine affirms its geopolitical affiliation with the common European space. It shares the common values of democracy, the rule of law, shows respect for international law and human rights, and is committed to upholding these values in every possible way.

The prospects of Ukraine's accession to the EU are determined and it is concluded that the conscious European choice of our country is a response to the demands of the time. Presently, to preserve and assert its place in the European dimension, Ukraine should not only show determination in its declared intentions for European integration but also demonstrate strong political will, fulfill its commitments and take an active position in defending its own interests. The main tasks facing the country today are resolving territorial disputes (Crimea, certain districts of Luhansk and Donetsk regions), ending the armed conflict in eastern Ukraine, overcoming corruption, and implementing reforms which are urgent for the country. Addressing these key issues will greatly facilitate Ukraine's progress towards the EU.