bluuebunny/crossref_metadata_2025 huggingface dataset:
Shared und Mutual Beliefs in der Lehrerinnen- und Lehrerbildung. Untersuchung über die Beliefs von Lehrerausbildenden bezüglich des Lehrens, Lernens und der Rolle der Lehrperson
Authors: Steinmann Sibylle
Published: November 2021

Diese Studie untersucht die Beliefs, Shared Beliefs und Mutual Beliefs von Lehrerausbildenden bezüglich guten Unterrichts, rollenorientierten Zielvorstellungen von Lehrpersonen, Konstruktions- und Transmissionsorientierung sowie in Bezug auf das Verständnis des Verhältnisses von Theorie und Praxis. Die Unterscheidung nach Shared Beliefs (Übereinstimmung der Beliefs von mehreren Personen) und Mutual Beliefs (angenommene Shared Beliefs) erlaubt eine differenzierte Sicht auf die «gemeinsame Ausrichtung» der Lehrerausbildenden. Auf der Basis von quantitativen Daten wird ermittelt, in welcher Ausprägung und in welchen Bereichen zwischen drei Gruppen von Lehrerausbildenden, Dozierenden der Erziehungswissenschaft, Dozierenden der Fachdidaktik Mathematik und den Praxislehrpersonen, Shared und Mutual Beliefs bestehen. Die Studie kann aufzeigen, dass eine vermutete gemeinsame Ausrichtung (Mutual Beliefs) der Lehrerausbildenden bezüglich der rollenorientierten Zielvorstellungen von Lehrpersonen einen positiven Einfluss auf die Qualität der Lehrerinnen- und Lehrerbildung hat.
Game-based learning in medical education
Authors: Mani Dixit Sanjaya
Published: November 2021

Not applicable.
Clinical profile and outcome of children with acute bacterial meningitis in a tertiary care centre in eastern Nepal
Authors: Bhatta Mukesh , Kafle Shyam Prasad , Rai Basant , Subedi Rejeena
Published: November 2021

Background: Bacterial meningitis is a severe infection of the central nervous system with varied clinical presentations. It is associated with substantial mortality and morbidity.
Objectives: The objective of this study was to assess the clinical profile, including the clinical features, laboratory and radiological parameters, clinical course, treatment, response to treatment, complications, and outcome of children at discharge.
Methods: A prospective observational study was conducted among 52 inpatient children of acute bacterial meningitis aged one month to 14 years over a period of six months. The patients were enrolled during admission and followed up daily till discharge. Socio-demographic, clinical, and diagnostic details and outcomes were recorded and analysed using statistical package for social sciences version 20.
Results: The median age of the patients was two years with male to female ratio of 2:1. Fever (45, 87%), vomiting (37, 71%), seizure (33, 64%) and headache (22, 46%) were the most common symptoms. The cerebrospinal fluid culture was positive in three (6%) cases. Complications were seen in 20 (39%) patients including four (7.7%) deaths. Patients with prolonged fever, malnutrition, loss of consciousness, ear discharge, presence of meningeal signs, abnormal pupil, high cerebrospinal fluid protein, positive cerebrospinal fluid, and blood culture, low blood pH, and hyperlactataemia were significantly associated with complications (p <0.05).
Conclusion: Factors like malnutrition, longer duration of fever, and abnormal neurological and laboratory findings were associated with higher rates of complications.
Drain or no drain in Rhomboid excision and Limberg rotational flap for pilonidal sinus
Authors: Joshi Arbin , Acharya Bigyan
Published: November 2021

Background: Healing in Rhomboid flap for pilonidal sinus is always a problem. Different measures are applied to reduce the rate of wound infection with variable results.
Objectives: To determine the effect of routine use of drain on the rate of early wound complications and additional interventions after Rhomboid flap. 
Methods: A retrospective chart review of all cases that underwent Rhomboid flap in five years in two tertiary care centres was done. Complication rates such as wound infection, wound disruption, and flap necrosis were evaluated.
Results: A total of 38 cases of Rhomboid flap are included for analysis. Out of all cases 37 cases were done for Pilonidal sinus and one case for presacral dermoid cyst. In the first eight cases, flap was made without drain and subsequent 30 cases were done with two suction drains for five days. The rate of superficial wound infection in the group without drain was found to be significantly higher compared with flap with drain 5 (in 8) versus 2 (in 30) (62.5% versus 6.66%, p <0.5). 
Conclusion: Drain placement after Rhomboid flap is a good intervention to reduce wound infection.
Eosinophilic pleural effusion in an eleven-year-old boy
Authors: Shakya Kashyap Narsingh , Shrestha Anup , Yadav Arabindra , Gautam Uttara , Panday Rajesh Kumar , Lamichhane Mira
Published: November 2021

Pleural effusion fluid with ?10% eosinophils may be seen in 5-16% of exudative pleural effusions. Its association with helminthic infestation is reported in the literature. This patient with left-sided eosinophilic pleural effusion was a referred case from another hospital and treated initially as parapneumonic. With inadequate response to antibiotics and a markedly high IgE level praziquantel was started. This resulted in rapid disappearance of symptoms, decrease in the eosinophil count, and radiological improvement. After exclusion of parapneumonic, tuberculosis, autoimmune disease, and malignancy, a trial of antihelminthics should be considered an option. This may spare unnecessary investigations.
Superior subconjunctival dislocation of intraocular lens following blunt trauma: A rare case report
Authors: Gupta Sharad , Yadav Reena , Shrestha Satbodh , Bista Bipin , Gupta Vidisa , Chaudhary Sushma
Published: November 2021

Subconjunctival dislocation of the intraocular lens secondary to trauma is an unusual and serious condition in the pseudophakic eye. Here, a case of 75 years old male who had traumatic superior subconjunctival dislocation of intraocular lens to his right eye with cow’s horn is reported. The patient was managed with surgical extraction of the lens and planned for secondary intraocular lens implantation. It is quite challenging to manage such a case. Despite, proper surgical management visual outcomes are always guarded in such patients with blunt trauma.
Rastelli operation for double outlet right ventricle, pulmonary atresia with ductal dependent pulmonary flow
Authors: Panthee Nirmal , Pradhan Sidhartha , Koirala Raamesh , Pokhrel Bishow , Thapaliya Deekshya , Thakur Apurba , Jha Ujjwal , Timala Rabindra
Published: November 2021

Double outlet right ventricle (DORV) with or without pulmonary atresia is a common indication for Rastelli operation. We very infrequently perform this surgery in our center. Here, we report a case of a ten-year-old girl who recently underwent Rastelli operation and patent ductus arteriosus (PDA) ligation for DORV, pulmonary atresia with ductal dependent pulmonary circulation by using custom-made valved conduit
Klasifikasi Naïve Bayes pada Analisis Sentimen atas Penolakan Dibukanya Larangan Ekspor Benih Lobster
Authors: Sulastri Kartika
Published: November 2021

Penolakan mantan Menteri Kelautan dan Perikanan melalui Twitter atas dibukanya keran ekspor benih lobster mendapat respon positif dan negatif dari masyarakat. Opini masyarakat ini perlu diteliti untuk mendengar keluhan dan menyerap aspirasi masyarakat. Namun, untuk menghasilkan kata atau term dalam penelitian, beragam opini tersebut sulit untuk dipilah, karena terdapat beberapa kendala seperti penggunaan bahasa informal, adanya simbol, singkatan, bahasa asing atau bahasa daerah.  Untuk itu, penelitian ini menggunakan analisis sentimen. Dalam penelitian ini, opini masyarakat dikumpulkan dan diolah melalui beberapa tahapan, dimulai dari pengumpulan data mentah, pre-processing data, seleksi fitur, pemisahan data, klasifikasi, dan evaluasi.  Pre-processing data mencakup normalization, stemming, convert emoticon, convert negation, tokenizing, stopword removal, dan case folding. Seleksi fitur menggunakan Term Frequency; split data menggunakan Cross Validation; dan evalusi memanfaatkan Confusion Matrix. Tujuan penelitian ini adalah melakukan analisis sentimen dengan algoritma Naïve Bayes dengan lima rasio perbandingan pada data split antara data latih dan data uji untuk mendapatkan nilai evaluasi tertinggi. Jumlah data yang diambil sebanyak 200 sample tweet yang terbagi atas 116 opini positif dan 84 opini negatif. Penelitian ini menghasilkan nilai evaluasi tertinggi di mana accuracy adalah  72.50%; precision adalah 88.64%; recall adalah 62.42%, dan AUC adalah 86.50%.
IMPLEMENTASI LOAD BALANCING MENGGUNAKAN ANTRIAN ROUND ROBIN DENGAN STUDI KASUS E-SHOP
Authors: Geovanni Arnold Reza
Published: November 2021

Seiring dengan perkembangan teknologi, jumlah penggunaan layanan web semakin meningkat. Hal ini menyebabkan situs-situs web popular memiliki jumlah traffic yang tinggi. Salah satu web yang populer itu adalah e-shop. Masalah yang dihadapi adalah pada saat ada kegiatan atau acara tertentu dalam e-shop juga dapat menyebabkan naiknya jumlah traffic web suatu organisasi. Salah satu solusi untuk menangani masalah tersebut adalah dengan menggunakan sebuah server yang handal dengan performa yang tinggi. Solusi lain yang dapat diterapkan adalah teknologi load balancing.  Algoritma Round robin merupakan algoritma yang paling sederhana dan paling banyak digunakan oleh perangkat load balancing. Oleh karena itu dibuatlah sebuah web untuk mengimplementasikan load balancing menggunakan antrian round robin dengan studi kasus e-shop.  Proses pengujian pada penelitian ini dihitung menggunakan pengujian QoS terdiri dari empat parameter. Yang pertama, throughput yang dihitung dan menghasilkan nilai  kbps. Kedua, delay yang didapat dari hasil perhitungan yaitu , , , dan  digolongkan kedalam kategori sangat baik untuk penggunaan transaksi pada web e-shop. Ketiga, jitter yang didapat dari hasil perhitungan yaitu  yang digolongkan kedalam kategori sangat baik untuk penggunaan transaksi pada web e-shop. Terakhir, packet loss  yang didapat dari hasil perhitungan yaitu  digolongkan kedalam kategori sangat baik untuk penggunaan transaksi pada web e-shop.
Epistaxis: abordaje inicial en el servicio de emergencias
Authors: Medina Correas Natalia Verónica , Fung Fallas Michelle Pamela , Quesada Musa Cristina
Published: November 2021

La epistaxis es una hemorragia originada de la cavidad nasal y representa una de las urgencias otorrinolaringológicas más frecuentes a la que se enfrentan los médicos en los servicios de emergencias. Aunque a menudo su presentación es benigna, el sangrado nasal puede comprometer rápidamente el pronóstico vital, debido a su recurrencia o abundancia. Su etiología puede ser local o sistémica, no obstante, en la mayoría de casos la causa de la epistaxis permanece idiopática. Un abordaje exitoso por parte del profesional de la salud requiere el conocimiento del mismo sobre la anatomía nasal, riesgos potenciales y complicaciones de sus tratamientos. El manejo de la epistaxis con frecuencia es demandante y debe ser oportuno con medidas iniciales de resucitación, terapia de compresión nasal, cauterización e incluso puede ameritar resolución quirúrgica en sala de operaciones.
MASTERING RESEARCH SKILLS BY FUTURE ELEMENTARY SCHOOL TEACHERS UNDER THE CONDITIONS OF NON-STANDARD LESSON
Authors: Bisovetska Liudmyla , Surzhuk Tetiana
Published: November 2021

This study investigates the development of research skills in the course of higher education training programs for future elementary school teachers. The purpose of this article is to analyze the formation and development of the scientific and pedagogical outlook of higher education students by employing an innovative approach to traditional education. The article identifies the role of modern children’s books in the development of educational competencies by university students in the elementary education field.The authors suggest optimal methods for future teachers’ research competence development by using the material of modern children’s literature. The emphasis on the creative nature of teaching instruction and the application of learning technologies in the education process are outlined. The proposed design foundation for unconventional teaching methods is focused on generating interest in the content of the subject being taught, emphasizing creative approach to the learning exercise completion and ongoing pedagogical evaluation and research. These principles define the educational content and the teaching methods.The author underlines the importance of using the training method in the classroom for the independent assignments to activate the students’ creative potential and curiosity.The study shows how the training session in the works of modern children’s literature could contribute to the language quality and literary education improvements for future elementary school teachers.It is proposed in the article to design a system of training sessions to develop personal and professional competencies and skills required for the future elementary school teachers. The authors hope that the content of the article is of interest to all Ukrainian language students and educators of all levels from elementary to postgraduate education.
Keywords: educational process; research skills and competence; language and literary competence; children’s literature, integration; innovation in training; training, hands-on training.
THE ISSUE OF EDUCATION AT A HIGHER ESTABLISHMENT AND SIMULTANEOUS LEARNING A FOREIGN LANGUAGE
Authors: Dmytruk Veronika , Shevchyk Halyna
Published: November 2021

The article is devoted to the psychological and pedagogical substantiation of the expediency of learning foreign languages while studying in the institution of higher education. The authors analyse the current educational process in Ukrainian and identify the most important factors influencing the formation of qualified professionals and establish the role of foreign language in each of these factors. It was found that studying can be extremely intensified due to learning a foreign language. It is established that learning foreign languages increases a person’s ability to develop intellectually.
Keywords: pedagogical psychology; institution of higher education; foreign language; English language; training intensification; motivation; information management; information gathering; information processing.
MOTIVATING STUDENTS TO AUTONOMOUS LEARNING IN THE TRANSLATION STUDIES CLASSES
Authors: Komar Oleh
Published: November 2021

The article presents a research of the peculiarities of motivating students of the Faculty of Foreign Languages of Pavlo Tychyna Uman State Pedagogical University to autonomous learning in the classes of translation studies. The aim of the article is to find out the factors that can be effective in motivating undergraduate students to study autonomously while learning translation studies. The paper indicates that the current problems for both students and teachers are lack of knowledge and motivation, low level of self-motivation and self-awareness, conservative approach to the conduction of the class.The following research questions were formulated in order to develop relevant methodology and expect trustworthy findings: What can motivate students for autonomous learning? How do students develop their autonomy in the translation studies class? Which translation studies activities and materials can influence students’ motivation for autonomous learning?The research methodology is based on descriptive qualitative and quantitative methods, the use of relevant data collection tools, in particular observation in the classroom, interviews and questionnaires and the subsequent intervention into educational process.The results of the intervention give indications that motivation may lead to autonomy. Lack of motivation was determined as an explanation for the lack of autonomous action, and it is the key conclusion from the experimental data.Consequently, there is a strong relationship between higher levels of motivation and greater engagement in inside and outside the class activities, and the suggestion that motivation (i.e. intrinsic motivation) leads to autonomy does find theoretical and experimental support.
Keywords: motivation; intrinsic motivation; extrinsic motivation; autonomous learning; English language; translation studies; professional education; competence.
MODEL OF FORMATION OF ARTISTIC AND CREATIVE ACTIVITY OF FUTURE TEACHERS OF FINE ARTS IN THE PROCESS OF PROFESSIONAL TRAINING
Authors: Bin Yang
Published: November 2021

The article investigates the problem of the formation of artistic and creative activity of future teachers of fine arts in the process of professional training. In this context, the author characterizes its main structural components, namely: purpose, principles (nature, culture, humanization, subjectivity, science, problems, active interaction of environmental actors, additionality, optimization, creativity, support for creative initiatives of subjects educational environment, the formation of emotional and value attitude to the world). The article indicates the motivational, meaningful and activity components; highlights the pedagogical conditions (development of a positive attitude of future teachers of fine arts to artistic and creative activities; organization of artistic and creative activities of future teachers-artists on the basis of problem-based learning; use of information and computer technologies in the formation of artistic-creative activity of future teachers of fine arts in the process of professional training). The methods, techniques, forms and tools necessary for the formation of artistic and creative activity of future teachers of fine arts in the process of professional training, are mentioned by the author. Methods: problem-based learning, problem situation, problem statement, exploratory, research, heuristic conversation. Techniques: sharpness and surprises, paradoxes, the struggle of ideas, concretization and personification, comparison. Forms: lectures, practical, demonstration of problem experience, practical solution of a didactic problem, films-presentations, slide-films, debates, classes-opening. Means: textbooks, initial programs, technical equipment (computers, presentation equipment), map of psychological and art analysis of the work of art, map of assessment of figurative expressiveness and literacy of creative work.
Keywords: artistic and creative activity; artistic and creative work; artistic and pedagogical activity; future teachers of fine arts; fine arts; professional training; model; institution of higher education.
FEATURES OF TRAINING FUTURE TEACHERS OF TECHNOLOGY BY MEANS OF THE PRO 100 PROGRAM
Authors: Sokotov Yurii , Soroka Taras , Нavryshchak Halyna , Uruskyi Andrii
Published: November 2021

The article considers the importance of using computer-aided design (CAD) systems to train competitive specialists in their field, in particular future technology teachers, who must be responsive to change and be competent in all innovations in information and communication technologies.In particular, in the process of training teachers of CAD, technology is used for designing and engineering products, objects, technological processes, as well as controlling and developing technical documentation.The possibilities of the computer program PRO 100 are revealed: the majority of operations connected with designing are realized quickly and simply using the mouse; fast access to an additional set of tools such as positioning, alignment, rotation; six types of viewing of details; creation of new detail and storage in the library with new source data, calculation of the number of materials and accessories and their price.The advantages of using the PRO 100 program when designing furniture sets on the example of a kitchen cabinet are identified. They are as follows: 3D visualization allows you to view the product, both in general and in detail in all projections, which motivates students to design activities; the possibility of step-by-step and versatile design of products of varying complexity; possibility of self-control and constructive changes at any stage of designing.The structural elements of the kitchen cabinet are singled out, namely: the components of the product “received” the name, size, material for manufacture, which is reflected in the specification of parts, and at any stage of design, you can make changes and control the process.A clear algorithm for the sequence of logically-ordered actions for product design has been developed, which includes the following: specification of each design stage with the demonstration in the corresponding figure, proposed simpler ways to design parts for better assimilation.
Keywords: computer design; PRO 100 program; furniture products; element; detail; CAD; design and engineering activities; specialist; 3D-visualization; perspective.
Manajemen Bisnis Aerotropolis (Airport City): Sebuah Studi Pemetaan Sistematis
Authors: Ginanjar Jajang , Rizal Muhamad , Arifianti Ria
Published: November 2021

Penerapan konsep aerotropolis (kota bandara) di berbagai belahan dunia memerlukan perencanaan yang holistik. Aspek-aspek yang mempengaruhi terhadap implementasi kota bandara wajib menjadi pertimbangan dalam perencanaan. Keterkaitan antara regulasi, dukungan pemerintah, skema bisnis, kepemilikan lahan, serta sumber daya manusia, menjadi modal penting dalam mewujudkan sebuah kota bandara. Studi ini adalah riset awal yang bertujuan untuk mengidentifikasi hasil dari riset yang pernah dilakukan pada bidang pengelolaan bisnis Aerotropolis dengan menggunakan systematic mapping study (SMS). Tujuan dari pemetaan ini adalah untuk mengetahui topik Aerotropolis apa saja yang diteliti. Artikel ini memfokuskan pada 10 kota bandara di dunia yang telah mengaplikasikan model Aerotropolis dalam pengembangannya, yaitu Amsterdam, Paris, Dubai, Dallas, Chicago, Memphis, Hongkong, Singapore, Incheon, dan Washington. Studi ini menggunakan metode1kualitatif dengan melalui studi pustaka. Penelusuran dilakukan melalui Google Scholar. Dimaksudkan bahwa keluaran dari SMS ini dapat menggambarkan mengenai peluang dengan tujuan eksplorasi topik serta pemikiran baru dalam pengeloaan bisnis Aerotropolis (aerocity-airport city) selain dari eksploitasi topik yang telah ada sebelumnya.

Rekomendasi hasil studi dari Aerotropolis Development dengan fokus riset pada Aerotropolis Development Practices. Metode kualitatif paling banyak dilakukan dalam riset mengenai Aerotropolis ini.
Building Rapport
Authors: Ketonen-Keating Irene
Published: November 2021

How does sharing hidden but valuable magical information help Northern Ireland (NI) Catholic and Protestant farmers build rapport? I suggest that it serves as a form of cultural intimacy by emphasising common beliefs, while downplaying possibly conflicting ethnoreligious identities. Magical practices such as ‘curing/charming’ remain common among NI farmers. It refers to asking a person with ‘the cure’ for a specific condition (such as bleeding or heart disease) to heal a sufferer. During nine months of fieldwork, conducted between 2012 and 2014, I learned that farmers, inspectors, and NGO staff often discuss ‘curing’ during their bureaucratic encounters. One person mentions a relative who is sick. The other then provides contact information for a healer with ‘the cure’ for such an ailment. Both Catholics and Protestants practice ‘curing’ in very similar forms.
Panagiotes K. Chrestou (1917-1995): Patrologist, Theologian, Political Figure
Authors: Ларионов Александр , Ларионова Наталья Богдановна
Published: November 2021

В настоящей публикации представлен обзор жизни и научной деятельности одного из крупнейших православных учёных Греции XX в. - Панайотиса К. Христу. Профессор Фессалоникийского университета им. Аристотеля, министр образования Греческой Республики, сотрудник Вселенской Патриархии, исследователь, переводчик и издатель святоотеческих текстов, патролог - далеко не полный перечень должностей и видов деятельности, которые занимал и которым всецело посвятил себя П. Христу. Помимо биографии греческого профессора в статье представлена попытка показать его вклад в развитие православной науки в Греции, основанный на ознакомлении греческих богословских школ с наследием богословов русской эмиграции.

This publication provides an overview of the life and scientifi activities of Panagiotes K. Chrestou, one of the great Orthodox scientists in Greece in the 20th century. Professor at the Aristotle University of Thessaloniki, Minister of Education of the Hellenic Republic, employee of the Ecumenical Patriarchate, researcher, translator and publisher of patristic texts, patrologist - thisis not a complete list of positions and activities that P. К. Chrestou occupied and devoted himself entirely to. The article presents the biography of the Greek professor, and also makes an attempt to assess his contribution to the development of Orthodox science in Greece and familiarization of Greek theological schools with the legacy of theologians of the Russian emigration.
Dimethyl Fumarate is a Potential Therapeutic Option for Alzheimer’s Disease
Authors: Sun Xiaodi , Suo Xinjun , Xia Xianyou , Yu Chunshui , Dou Yan
Published: November 2021

Background: Dimethyl fumarate (DMF) has been approved for clinical treatment of multiple sclerosis based on its antioxidant and anti-inflammatory effects by activating the Nrf2 pathway. Since both oxidative stress and inflammation are involved in Alzheimer’s disease (AD), DMF is a potential therapeutic option for AD. Objective: This study aims to test the therapeutic effects of DMF on AD model mice and to reveal its underlying molecular mechanisms. Methods: Cell viability assay and in vitro immunofluorescence imaging were used to evaluate the antioxidant effect of DMF on embryonic mouse hippocampal neurons. Behavioral test and brain magnetic resonance imaging were used to assess the therapeutic effects of DMF on spatial learning and memory as well as hippocampal volume in AD model mice with and without Nrf2 knockdown. Western blotting was used to analyze the expression of antioxidant enzymes and molecules associated with AD-related pathological pathways. Results: DMF inhibits reactive oxygen species overproduction and protects neurons without Nrf2 knockdown from death. DMF reduces amyloid-β induced memory impairment and hippocampal atrophy in AD model mice rather than in Nrf2 knockdown AD mice. DMF delays the progression of AD by activating the Nrf2 pathway to enhance the expression of downstream antioxidant enzymes and inhibits lipid peroxidation, apoptosis, inflammation, mitochondrial dysfunction and amyloid-β deposition. Conclusion: These results indicate that DMF is a potential therapeutic option for AD through its antioxidant, anti-inflammatory, anti-apoptotic, and other anti-AD effects by activating the Nrf2 pathway.
Anti-Inflammatory Agents: An Approach to Prevent Cognitive Decline in Alzheimer’s Disease
Authors: Brod Staley A.
Published: November 2021

Systemic inflammation is an organism’s response to an assault by the non-self. However, that inflammation may predispose humans to illnesses targeted to organs, including Alzheimer’s disease (AD). Lesions in AD have pro-inflammatory cytokines and activated microglial/monocyte/macrophage cells. Up to this point, clinical trials using anti-amyloid monoclonal antibodies have not shown success. Maybe it is time to look elsewhere by combating inflammation. Neuroinflammation with CNS cellular activation and excessive expression of immune cytokines is suspected as the “principal culprit” in the higher risk for sporadic AD. Microglia, the resident immune cell of the CNS, perivascular myeloid cells, and activated macrophages produce IL-1, IL-6 at higher levels in patients with AD. Anti-inflammatory measures that target cellular/cytokine-mediated damage provide a rational therapeutic strategy. We propose a clinical trial using oral type 1 IFNs to act as such an agent; one that decreases IL-1 and IL-6 secretion by activating lamina propria lymphocytes in the gut associated lymphoid tissue with subsequent migration to the brain undergoing inflammatory responses. A clinical trial would be double-blind, parallel 1-year clinical trial randomized 1 : 1 oral active type 1 IFN versus best medical therapy to determine whether ingested type I IFN would decrease the rate of cognitive decline in mild cognitive impairment or mild AD. Using cognitive psychometrics, imaging, and fluid biomarkers (MxA for effective type I IFN activity beyond the gut), we can determine if oral type I IFN can prevent cognitive decline in AD.
Stochastic Epigenetic Mutations Influence Parkinson’s Disease Risk, Progression, and Mortality
Authors: Chen Gary K. , Yan Qi , Paul Kimberly C. , Kusters Cynthia D.J. , Folle Aline Duarte , Furlong Melissa , Keener Adrienne , Bronstein Jeff , Horvath Steve , Ritz Beate
Published: November 2021

Background: Stochastic epigenetic mutations (SEM) reflect a deviation from normal site-specific methylation patterns. Epigenetic mutation load (EML) captures the accumulation of SEMs across an individual’s genome and may reflect dysfunction of the epigenetic maintenance system in response to epigenetic challenges. Objective: We investigate whether EML is associated with PD risk and time to events (i.e., death and motor symptom decline). Methods: We employed logistic regression and Cox proportional hazards regression to assess the association between EML and several outcomes. Our analyses are based on 568 PD patients and 238 controls from the Parkinson’s disease, Environment and Genes (PEG) study, for whom blood-based methylation data was available. Results: We found an association for PD onset and EML in all genes (OR = 1.90; 95%CI 1.52-2.37) and PD-related genes (OR = 1.87; 95%CI 1.50-2.32). EML was also associated with time to a minimum score of 35 points on the motor UPDRS exam (OR = 1.28; 95%CI 1.06-1.56) and time to death (OR = 1.29, 95%CI 1.11-1.49). An analysis of PD related genes only revealed five intragenic hotspots of high SEM density associated with PD risk. Conclusion: Our findings suggest an enrichment of methylation dysregulation in PD patients in general and specifically in five PD related genes. EML may also be associated with time to death and motor symptom progression in PD patients.
Evaluation of Bedside Tests of Attention and Arousal Assessing Delirium in Parkinson’s Disease, Dementia, and Older Adults
Authors: Lawson Rachael A. , Richardson Sarah J. , Kershaw Daisy , Davis Daniel , Stephan Blossom C.M. , Robinson Louise , Brayne Carol , Barnes Linda , Burn David J. , Yarnall Alison J. , Taylor John-Paul , Parker Stuart , Allan Louise M.
Published: November 2021

Background: Delirium is a serious acute neuropsychiatric condition associated with altered attention and arousal. Objective: To evaluate simple bedside tests for attention and arousal to detect delirium in those with and without Parkinson’s disease (PD) and dementia. Methods: Participants from two prospective delirium studies were pooled comprising 30 with PD without cognitive impairment, 24 with Lewy body cognitive impairment (PD dementia or dementia with Lewy bodies), 16 with another dementia and 179 PD and dementia-free older adults. Participants completed standardised delirium assessments including tests of attention: digit span, Memorial Delirium Assessment Scale (MDAS) attention and months of the year backwards; and arousal: Glasgow Coma Scale (GSC), Observational Scale of Level of Arousal (OSLA), Modified Richmond Agitation Scale and MDAS consciousness. Delirium was diagnosed using the DSM-5 criteria. Results: On their first admission, 21.7%participants had prevalent delirium. Arousal measures accurately detected delirium in all participants (p < 0.01 for all), but only selected attention measures detected delirium in PD and dementia. In PD and dementia-free older adults, impaired digit span and OSLA were the optimal tests to detect delirium (area under the curve [AUC] = 0.838, p < 0.001) while in PD and dementia the optimal tests were MDAS attention and GCS (AUC=0.90 and 0.84, respectively, p < 0.001 for both). Conclusion: Simple bedside tests of attention and arousal at a single visit could accurately detect delirium in PD, dementia and PD and dementia-free older adults; however, the optimal tests differed between groups. Combined attention and arousal scores increased accuracy, which could have clinical utility to aid the identification of delirium neurodegenerative disorders.
Visual notations for viewing RDF constraints with UnSHACLed
Authors: Lieber Sven , De Meester Ben , Heyvaert Pieter , Brückmann Femke , Wambacq Ruben , Mannens Erik , Verborgh Ruben , Dimou Anastasia
Published: November 2021

The quality of knowledge graphs can be assessed by a validation against specified constraints, typically use-case specific and modeled by human users in a manual fashion. Visualizations can improve the modeling process as they are specifically designed for human information processing, possibly leading to more accurate constraints, and in turn higher quality knowledge graphs. However, it is currently unknown how such visualizations support users when viewing RDF constraints as no scientific evidence for the visualizations’ effectiveness is provided. Furthermore, some of the existing tools are likely suboptimal, as they lack support for edit operations or common constraints types. To establish a baseline, we have defined visual notations to represent RDF constraints and implemented them in UnSHACLed, a tool that is independent of a concrete RDF constraint language. In this paper, we (i) present two visual notations that support all SHACL core constraints, built upon the commonly used visualizations VOWL and UML, (ii) analyze both notations based on cognitive effective design principles, (iii) perform a comparative user study between both visual notations, and (iv) present our open source tool UnSHACLed incorporating our efforts. Users were presented RDF constraints in both visual notations and had to answer questions based on visualization task taxonomies. Although no statistical significant difference in mean error rates was observed, all study participants preferred ShapeVOWL in a self assessment to answer RDF constraint-related questions. Furthermore, ShapeVOWL adheres to more cognitive effective design principles according to our performed comparison. Study participants argued that the increased visual features of ShapeVOWL made it easier to spot constraints, but a list of constraints – as in ShapeUML – is easier to read. However, also that more deviations from the strict UML specification and introduction of more visual features can improve ShapeUML. From these findings we conclude that ShapeVOWL has a higher potential to represent RDF constraints more effective compared to ShapeUML. But also that the clear and efficient text encoding of ShapeUML can be improved with visual features. A one-size-fits-all approach to RDF constraint visualization and editing will be insufficient. Therefore, to support different audiences and use cases, user interfaces of RDF constraint editors need to support different visual notations.
Decoding of the coupling between the brain and facial muscle reactions in auditory stimulation
Authors: Soundirarajan Mirra , Kuca Kamil , Krejcar Ondrej , Namazi Hamidreza
Published: November 2021

BACKGROUND: Analysis of the reactions of different organs to external stimuli is an important area of research in physiological science. OBJECTIVE: In this paper, we investigated the correlation between the brain and facial muscle activities by information-based analysis of electroencephalogram (EEG) signals and electromyogram (EMG) signals using Shannon entropy. METHOD: The EEG and EMG signals of thirteen subjects were recorded during rest and auditory stimulations using relaxing, pop, and rock music. Accordingly, we calculated the Shannon entropy of these signals. RESULTS: The results showed that rock music has a greater effect on the information of EEG and EMG signals than pop music, which itself has a greater effect than relaxing music. Furthermore, a strong correlation (r= 0.9980) was found between the variations of the information of EEG and EMG signals. CONCLUSION: The activities of the facial muscle and brain are correlated in different conditions. This technique can be utilized to investigate the correlation between the activities of different organs versus brain activity in different situations.
APPLICATION OF CIRCLES FOR CONJUGATION OF FLAT CONTOURS OF THE FIRST ORDER OF SMOOTHNESS
Authors: Koval Galyna , Lazarchuk Margarita , Ovsienko Liudmila
Published: November 2021

In geometric modeling of contours, especially for conjugation of sections of flat contours of the first order of smoothness, arcs of circles can be applied. The article proposes ways to determine the equations of a circle for two ways of its problem: the problem of a circle with a point and two tangents, none of which contains a given point, and the problem of a circle with three tangents. The equations of the circles were determined in both cases using a projective coordinate system.

In the first case, when a circle is given by a point and two tangents, neither of which contains this point, the center of the conjugation circle is defined as the point of intersection of two locus of points - the bisector of the angle between the tangents and the parabola, the focus of which is a given point. given tangents. In the general case, there are 2 conjugation circles for which canonical equations are defined. Parametric equations of conjugate circles, the parameters of which are equal to 0 and ∞ on tangents and equal to one at a given point, with the help of affine and projective coordinates of points of contact are determined first in the projective coordinate system, and then translated into affine system.

For the second case, when specifying a circle using three tangent lines, the equation of the second-order curve tangent to these lines is first determined in the projective coordinate system. The tangent lines are taken as the coordinate lines of the projective coordinate system. The unit point of the projective coordinate system is selected in the metacenter of the thus obtained base triangle. The equation of the tangent to the base lines of the second order contains two unknown variables, positive or negative values ​​which determine the location of four possible tangents of the second order. After writing the vector-parametric equation of the tangent curve of the second order in the affine coordinate system, the equation is written to determine the parameters of cyclic points. In order for the equation of the tangent curve of the second order obtained in the projective plane to be an equation of a circle, it must satisfy the coordinates of the cyclic points of the plane, which allows to write the second equation to determine the parameters of cyclic points. By solving a system of two equations, we obtain the required equations of circles tangent to three given lines.
SYSTEMATIC GRAPHICALLY-INTERPRETED MODELS OF CREATION OF ENERGY EFFICIENT BUILDINGS
Authors: Koshevaya Victoria , Koshevyi Oleksandr , Trobiuk Oleksandr
Published: November 2021

The article considers the creation of systematic graphically-interpreted models for matrix analysis of energy saving measures in the design of residential energy efficient and passive buildings, reconstruction of residential and historical buildings and the creation of energy-active architectural objects using alternative energy sources. Energy-efficient design of new buildings and modernization of old ones remains an urgent task. Ukraine's construction organizations are increasingly interested in reducing energy consumption and introducing energy-saving technologies. Scientists are trying to make housing more energy efficient, namely, consuming less energy compared to ordinary buildings and not polluting the environment. Increasing the level of energy supply and reducing the individual costs of servicing the house will allow solving the problem of creating graphically interpreted models of energy efficiency of the building and energy costs. The analysis is based on a combination of active and passive energy conservation measures and takes into account possible limitations based on a system approach in the construction of an integrated model of an energy active building.

The analysis is based on a combination of active and passive energy saving measures and takes into account possible limitations based on a systematic approach by creation a comprehensive model of an energy-active building.
Islamic Finance
Authors: Dr. Sabbah Gueddoudj
Published: November 2021

The aim of this paper is twofold. The first aim is to demonstrate that Islamic finance is an alternative to conventional finance in the western world. Often viewed as a religious service in non-Muslim countries, Islamic finance has been excluded from economic funding, unfortunately. This exclusion is partly linked to a lack of knowledge about Islamic finance in Europe. Most of the time, Islamic finance is associated with Islamic religion without taking into account economic concerns. An exercise of comparison between Islamic principles and various monetary schools of thought demonstrates that there are similarities between them and that Islamic finance cannot be perceived without understanding core economic and financial rules. The second aim of this paper is to evaluate the position of Islamic finance as ethical finance in Luxembourg and its various perspectives. The main conclusions are 1) Islamic finance should be studied through an economic prism, 2) Islamic finance in Luxembourg has steadily increased but, 3) its share in financial instruments is still very low despite the openness towards non-conventional finance funding in Luxembourg.
Pengaruh Desain, Lokasi, Dan Investasi Terhadap Keputusan Pembelian Rumah Pada Perumahan Mutiara Regency Kota Sorong
Authors: Waly Nur Aeni , Yusuf Ana Varadila , Iriani Latifah Dian
Published: November 2021

Penelitian ini bertujuan untuk mengetahui pengaruh desain, lokasi, dan investasi terhadap keputusan pembelian rumah pada perumahan mutiara regency kota Sorong. Populasi penelitian ini adalah para konsumen di perumahan mutiara regency. Teknik pengambilan sampel yang digunakan adalah probability sampling dengan menggunakan metode Simple Random, 52 orang sebagai sampel. Teknik pengumpulan data yang digunakan adalah Kuisoner. Metode analisis data yang digunakan adalah analisis regresi berganda. Hasil analisis data menunjukkan bahwa desain, lokasi, dan investasi secara bersama-sama berpengaruh positif dan signifikan terhadap keputusan pembelian dengan nilai thitung sebesar 3,174 dan signifikansi 0,000.
Rancang Bangun Water-Oil Separator Tipe Horizontal Dua Fasa Menggunakan Variasi Minyak Goreng, Pertamina Dex Dan Oli Mesin
Authors: Astuti Edi Tri , Aritonang Jones , Sebayang Perdamean , Simbolon Silviana
Published: November 2021

Industri terus berkembang setiap tahun, dan jumlah limbah yang dihasilkan juga meningkat, yang menyebabkan seringnya tumpahan minyak dan meningkatkan jumlah air limbah berminyak yang dihasilkan oleh industri. Pencemaran minyak merupakan masalah lingkungan yang sangat penting untuk dipecahkan. Water-oil separator adalah alat yang digunakan untuk memisahkan air dan minyak, dilakukan dengan mengubah kecepatan terapung suatu benda atau partikel berdasarkan massa jenis dan ukurannya. Rancang Bangun Water-Oil separator Tipe Horizontal Dua Fasa Menggunakan Variasi Minyak Goreng, Pertamina Dex Dan Oli Mesin merupakan penelitian yang bertujuan untuk menerapkan pemisahan air-minyak pada sistem water-oil separator. Pada penelitian ini sistem Water-oil separator diuji menggunakan variasi minyak goreng, pertamina dex dan oli mesin, dimana air dan minyak dipisahkan dengan debit minyak 1,2,3 l/menit dan kondisi debit air konstan 1 l/menit. Pengujian pada fluida minyak dan air menunjukkan pengaruh terhadap efisiensi pemisahan minyak dan air, semakin tinggi debit fluida minyak maka dan air cenderung turun, nilai efisiensi pemisahan minyak dan air akan semakin naik, dimana nilai tertinggi efisiensi pemisahan minyak dan air terdapat pada debit fluida minyak 3 l/min pada kondisi debit air konstan 1 l/min dengan nilai 94,1 %, 90,8 % dan 89 %, sedangkan nilai terendah efisiensi pemisahan minyak dan air terdapat pada debit fluida minyak 1 l/min pada kondisi debit air konstan 1 l/min.
Greenhouse Monitoring and Controlling System, Study Case "Strawberry"
Authors: Manalu Istas Pratomo , Simamora Sanita , Siregar Ruben Mual , Manik Alexius Humbang , Manalu Andriono
Published: November 2021

The application of technology in agriculture has become several indicators of progress and developments in technological science. The more specific technology used in IoT (Internet of Things) that the use of the internet network is one of the main factors in developing automated technological machines to improve agricultural systems. Therefore, the use of IoT is very useful in agriculture, especially in strawberry cultivation, which requires s control in every maintenance process, namely for several main activities such as watering, fertilizing, and monitoring temperature and plant conditions in real-time. Through this research and development, it is hoped that the IoT system will be designed using Node-RED as visual programming and will connect to the MQTT protocol as a protocol in data and information transmission. Node-RED is the new technology that use to facilitate the process of implementing the IoT system and controlling and monitoring every data and order received and made. The research method starts from data collection, designing models, collecting tools and materials, conducting tests, implementing tools to objects, and evaluating each implementation process that has been running. The hopes and targets of the Greenhouse Monitoring and Controlling System, Study Case “Strawberry” can reduce farmer labor, time efficiency with a automation system, and be able to maintain the optimal growth process of strawberry plants.
Therapy through Theatre: Duncan Macmillan’s Every Brilliant Thing
Authors: PALA Yavuz
Published: November 2021

This paper analyses Every Brilliant Thing (2013) by the contemporary British playwright Duncan Macmillan with regard to grief and bereavement theories. The main focus here is the meaning reconstruction during grief and bereavement period in the light of the ideas of psychiatrists such as Sigmund Freud, William Worden, Dennis Klass and Robert A. Neimeyer. The study examines, on the one hand, the loss of meaning, existential questioning and suicidal depression of the chief character in the play whose mother commits suicide; on the other, reconstruction of meaning and self in bereavement period through interactive stand-up comedy. Focusing on the latest developments in clinical studies about meaning reconstruction and their successful outcomes in grief and bereavement period after a tragic loss through expressive arts, the paper discusses whether theatre, an expressive art, can be used as a laboratory or a clinic in solving contemporary social and individual problems. In this sense, Macmillan’s play provides us with fruitful information about new trends of the contemporary theatre. The purpose of the paper is to discuss the role of theatre in the healing process of diseases that are related to modern life respecting social responsibility that is a common tendency of contemporary theatre.