bluuebunny/crossref_metadata_2025 huggingface dataset:
Crónica de la Jurisprudencia del Tribunal de Justicia de la Unión Europea
Authors: Ordoñez Solís David
Published: April 2020

Sumario: I. Introducción. La separación de poderes importa.— II. Primera parte. Los desarrollos jurisprudenciales del derecho de la Unión Europea. 1. Los derechos fundamentales de la Unión. a) El alcance territorial del derecho al olvido en Internet: sentencia Google France / CNIL. b) El consentimiento y las cookies en Internet: sentencia Planet49. c) Los deberes de cesación de ilícitos en las redes sociales. d) La legalidad de los datos biométricos de trabajadores turcos. 2. El mercado único europeo: sentencia Airbnb Ireland. 3. El espacio de libertad, seguridad y justicia para los extranjeros. 4. La responsabilidad y el control en la transposición de las directivas. a) La sentencia AW, el 112 y la responsabilidad por mala transposición de la Directiva en Lituania. b) Bélgica condenada a una multa coercitiva por no informar sobre la transposición de una Directiva.—III. Segunda parte. La Jurisprudencia Europea provocada por los jueces españoles y sus efectos en el derecho interno. 1. El alcance de la inmunidad de los eurodiputados: sentencia Junqueras. 2. La protección social de los trabajadores en la jurisprudencia del Tribunal de Justicia. a) La aplicación de la Carta en materia social y la sentencia Ortiz Mesonero. b) La discapacidad en el ámbito laboral y la sentencia DW / Nobel Plastiques Ibérica. c) El empleo público temporal y el alcance de la Directiva 1999/70: auto Aragón Carrasco. d) El cálculo de la antigüedad de los trabajadores fijos discontinuos de la Agencia tributaria. e) La pensión de jubilación anticipada en España y la cotización en Alemania: sentencia Bocero Torrico. 3. La protección de los consumidores frente a las cláusulas abusivas y el poder del juez. 4. El sistema tributario español y el Derecho de la Unión Europea. a) La impugnación por las compañías eléctricas de los tributos y otras contribuciones. b) La devolución de aranceles abonados sin error imputable a las autoridades aduaneras de terceros países: sentencia Prenatal. 5. Los derechos derivados de la protección de variedades vegetales.—IV. Relación de las sentencias comentadas.Publicación en línea: 02 abril 2020
Guías de Práctica Clínica para la prevención, detección temprana y tratamiento de las complicaciones del embarazo, parto o puerperio: introducción y metodología
Authors: Gómez-Sánchez Pío Iván , Arévalo-Rodríguez Ingrid , Rubio-Romero Jorge Andrés , Amaya-Guío Jairo , Osorio-Castaño John Henry , Buitrago-Gutiérrez Giancarlo , Desarrollador de la Guía Representantes Grupo
Published: April 2020

Antecedentes: las “Guías de Práctica Clínica (GPC) para la prevención, detección temprana y tratamiento de las alteraciones del embarazo, parto y el puerperio” fueron desarrolladas por la alianza conformada por la Universidad Nacional de Colombia, la Universidad de Antioquia, la Universidad Pontificia Javeriana y el Centro de investigaciones en evaluación de tecnologías en salud (CINETS) dentro de la convocatoria del Ministerio de Salud y Protección Social y Colciencias en el año 2010 para el desarrollo de GPC en temas prioritarios de salud.Materiales y métodos: basados en la “Guía Metodológica para la elaboración de GPC” del Centro de Estudios e Investigación en Salud (CEIS), se conformó el grupo desarrollador, se definieron los tópicos por desarrollar, el alcance, los objetivos y las preguntas por resolver en las GPC. Se realizó una búsqueda sistemática de GPC para los tópicos seleccionados, priorizando la opción de adaptar antes que desarrollar una guía de novo, según la calidad metodológica de las guías identificadas. Se realizó la revisión sistemática de la literatura para responder preguntas huérfanas. Se formularon las recomendaciones con niveles de evidencia graduados bajo el sistema SIGN. Se favoreció la participación de pacientes y de los diferentes grupos de interés.Resultados: se adaptaron seis GPC para responder las preguntas de los tópicos incluidos en la GPC desarrollada. El tópico de toxoplasmosis requirió el desarrollo de recomendaciones de novo.Conclusiones: estas GPC fueron elaboradas con procedimientos sistemáticos y la mejor evidencia disponible. Se espera que contribuya a mejorar la calidad de la atención de las gestantes y a la disminución de la morbilidad y mortalidad materna y perinatal.
2019 European guidelines on the diagnostics and management of acute pulmonary thromboembolism: the comments from the experts of the Russian Cardiology Society and the Russian Respiratory Society
Authors: Avdeev S. N. , Vavilova T. V. , Goncharova N. S. , Karelkina E. V. , Karpova D. V. , Nifontov E. M. , Novikov V. K. , Simakova M. A. , Yakovlev A. N. , Moiseeva O. M.
Published: April 2020

Novel guidelines presented at the annual congress of the European Society of Cardiology 2019 changed our knowledge on management of the acute pulmonary thromboembolism. They cover the issues of the risk stratification, management strategy in acute phase considering prognostic criteria nad patient’s hemodynamic stability, duration and scheme of the anticoagulation therapy in order to prevent thromboembolism recurrencies, management of patients with malignant tumors and in pregnant women, as well as the diagnostic and treatment approaches in postthrombotic syndrome. In the review, the experts of the Russian Cardiology Society and Russian Respiratory Society discuss the main questions and changes in the Guidelines on the acute pulmonary thromboembolism.
Polysomnography or cardiorespiratory monitoring: what is the best method to diagnose sleep-disordered breathing?
Authors: Agaltsov M. V.
Published: April 2020

Polysomnography and cardiorespiratory (respiratory) sleep monitoring are the most common diagnostic methods for respiratory sleep disorders. Polysomnography traditionally takes the place of the “gold” standard for detection of all types of respiratory events since its inception. Currently, cardiorespiratory monitoring of sleep is becoming more widespread as a diagnostic method with a minimum set of parameters for determining respiratory events during sleep. The increased use of cardiorespiratory (respiratory) monitoring of sleep is due to 2 reasons: the increased need for diagnosis due to the wide occurrence of respiratory disorders in the population and the conditions of the method (simple use, the need for a sleep laboratory, cheaper cost). However, the method is not indicated to all patients. Potential limitations for cardiorespiratory monitoring of sleep are the lack of sleep recording (information about the structure of sleep and reactions of sleep to respiratory disorders), monitoring of the study by medical personnel, and absence of body position sensor. These factors influence the assessment of the severity of the disease and the verification of certain forms of the disease. Currently, new methods of screening sleep apnea have been formed, based on modern innovative technologies and available in practical medicine. These include the determination of the presence of respiratory events be ECG Holter monitoring during sleep, the recognition of snoring and respiratory events in sleep from an audiometric signal recording and the determination of the probability of apnea with the help of registration movements during sleep (actigraphy).
Draft resolution of the expert council of the сhief specialists of the North-West Federal District on the identification of prediabetes and the prevention of type 2 diabetes mellitus and related diseases of cardiovascular system, liver, musculoskeletal system
Authors: Grineva E. N. , Mazurov V. I. , Khalimov Yu. Sh. , Bakulin I. G. , Panov A. V. , Tyrenko V. V. , Novikova I. A. , Babenko A. Yu. , Karonova T. L. , Banshikov G. T. , Leboeva M. M. , Lole O. Yu. , Ryabova N. Yu. , Toinov A. A. , Semko A. A. , Sheinskaya I. M.
Published: April 2020

Considering high prevalence of prediabetes, exceeding the incidence of type 2 diabetes mellitus, clear algorithms for identifying and managing patients with this pathology is the most important task for doctors of various specialties — therapeutists, cardiologists, general practitioners. The preventive measures are more efficient when started at the stage of prediabetes rather than when type 2 diabetes mellitus has been developed. They help to prevent or delay the development of type 2 diabetes mellitus, its micro- and macrovascular complications, cardiovascular diseases, pathology of muscular-skeletal system and liver. All these measures should be implemented at the stage of primary health care. The resolution presents an algorithm of verifying and management of prediabetes and type 2 diabetes mellitus.
Researching eighteenth-century fraud in the Old Bailey: reflections on court records, archives, and digitisation
Authors: Griffiths Cerian Charlotte
Published: April 2020

This article seeks to provide reflection and guidance to researchers of fraud in Britain during the eighteenth and nineteenth centuries. This reflection explains two reasons why there is a dearth of historical research into fraud offences. These reasons are ontological and methodological. The definitions and laws of fraud are complex and difficult to identify, and one of the most accessible court archive, the Old Bailey Sessions Papers (the Proceedings), needs to be treated with caution by the researcher of fraud. This article uses the in-depth historiography surrounding the Proceedings and applies this to the research of fraud offences which, this article argues, require a particular methodological approach.
Efficacy, impact and English legal history
Authors: Watkin Thomas Glyn
Published: April 2020

Theorists of law and of social policy distinguish between the efficacy and the impact of laws and legislation. Efficacy concerns the achievement of the effects intended by law-makers. Impact refers to the actual consequences. At times, the two diverge. Sometimes, it is only after a lengthy period that the impact is appreciated. The impact sometimes requires intervention by legislators or judges acting purposively in order to correct unforeseen or unfortunate consequences. The extent of judicial intervention is not always clear from the surviving records. This article argues that an awareness of the possibility of such occurrence is essential if legal history is to present the whole truth concerning legal developments.
Social Media as a Contemporary Communication Tool Between a City and its Users – a Theoretical Approach
Authors: Sędkowski Michał
Published: April 2020

Social media have become a standard in contemporary communication. That is especially true for business which jumped at the opportunity to con­nect with current and prospective customers allowing them to integrate with their favourite brands and products even further. This trend, however, seems to be absent in the public domain. Local authorities notice social media but attempt to use it in a one-to-many format, which is incompatible with the interactive nature of the new medium. Cities can strongly benefit from an active presence in the social sphere as it opens new paths to co-governance and better communication.
Archiving and Re-using of Qualitative Data as a Path to Development of Public Administration Research
Authors: Gajda Joanna
Published: April 2020

In response to the assumptions of new public management models and public or good governance, practical aspects of research in the area of public admin­istration and the development possibilities of qualitative research methods are presented in the article. Due to the fact that qualitative research has become increasingly popular in the above disciplines, data archiving and trans­parency is discussed (Moravcsik), (Yom et al.) and guidelines and principles are established (American Political Science Association). However, there is a lot of controversy among scholars (Monroe), and some examples are missing. This paper presents the challenge of ‘openness’ in the empirical activities (or empirical practice) of researchers. Its purpose is to present the archiving data potential from in-depth interviews on the example of a small set of qualitative data from research in the field of public administration. Firstly, the basic assumptions of new models of functioning of public administration and related consequences for researchers are described. In the second part, the challenges related to openness in contemporary public administration models are briefly mentioned. Next, the method of creating an archive from existing data, individual stages, documents, and data is outlined; it is based on the au­thor’s best practice on Qualidata (American Political Science Association; Van den Eynden et al.) and DA-RT principles.1 The summary includes examples of probable opportunities and challenges related to usage of data archiving for the research in public administration and political science development.
Ingvar the Far-Travelled: between the Byzantium and Caucasus. A Maritime Approach to Discussion
Authors: Böhm Marcin
Published: April 2020

The Journey to the East of the Viking Ingvar the Far-Traveled is one of the events that fit into the history of medieval relations of the Scandinavians with the world of Byzantium. It was a fateful expedition taking place between 1036 and 1041, and to this day it is a source of many controversies and speculations of researchers. The findings of the present paper suggest that the journey did not necessarily proceed to the lands of the Saracens or Byzantium but may have been part of the game played by Constantinople with its ally Tmutarkan, which opposed Jaroslav the Wise, these events unfolding in the north-eastern waters of the Black Sea.
The Relief on the Door of the Msho Arakelots Monastery (1134) as a Source for Studying Arms and Armour of Medieval Armenian Warriors
Authors: Dymydyuk Dmytro
Published: April 2020

Byzantium’s arms and armours were researched by many historians. For that reason, the military history of the medieval Roman Empire enjoyed a dominant position in medieval historiography, with the consequence that very often the military history of small nations (under Roman influences) was written from the perspective of the Eastern Romans historians. The aim of the paper is to change this perspective and give the subject of the medieval Armenian military the attention it deserves. The idea is to perform an analysis of the relief on the Door of the Msho Arakelots monastery, where four equestrians and one infantryman are depicted, and to compare it with other Armenian, Byzantine and Muslim sources. In this relief, a spherical mace head and a sword with sleeve cross-guard are represented, suggesting many parallels with East-Roman archaeological and figurative sources. No less important is the depiction of the military trumpet because it is the first image of this object in Armenian art, which can be compared with pictures from the Madrid Skylitzes (13th c.). In addition, the only defensive weapon which is presented in this relief is a round shield with a floral ornament. There are many depictions of round shields in Armenian miniatures and reliefs from 10th–11th c. Moreover, this relief is one of the few where stirrups and the chape of a scabbard are shown. These elements represent an important piece of information because these pictures can be compared with actual archaeological East-Roman artefacts to reconstruct their real look. The conclusions are that the majority of Armenian weapons bear similarities to Byzantine ones but no less important are the Muslim influences, which have been found in some cases. Located between two civilizations (Byzantium and the Muslim Potentates), Armenians adopted the best solutions of their military technologies, creating their own culture. Moreover, thanks to this comparative analysis, further support will be given to the idea that medieval figurative sources are more or less accurate material for studying medieval military history.
Reading and Annotating Galen between 1515–1531: on some Latin Galen Editions in the Library of the Carmelites in Cracow
Authors: Koźluk Magdalena
Published: April 2020

Copies of early-printed books have been of interest to to-day’s collectors and researchers not only for their material aspects (names of publishers and places of printing, fonts and composition, number of known copies etc.), but also because they bear signs of their often erratic history following their publication. The path followed by a particular copy of an early-printed book is reflected in its general state as an object (for instance the state of its binding), but also in its internal aspect. On the pages of a copy of an early-printed book, annotations, drawings doodles or graphics testify to the intimate relationship that its owners entertained with it. To better understand how owners dealt with copies of the books they possessed, this paper examines the annotations found in copies of some books that belong to the Carmelite convent in Cracow. We hope to bring to the attention of scholars, copies of works of Galen housed in this library, and primarily to set a perspective on how books were read by cultured individuals of in the 16th century period. To do so, we analyse copies of the 1507 Venice edition of the Articella and a copy of Latin edition of Galien (Iuntae, Venice, 1531). We attempt to identify the intellectual perspectives from which cultured readers approached such texts in the 16th century.
Time as a Dimension of Byzantine Identity
Authors: Koder Johannes
Published: April 2020

The notion of identity (tautotes) was discussed, often in contrast to its opposite “otherness” (heterotes), not only during Classical Antiquity but also by Christian and Byzantine authors since Late Antiquity. Fundamental manifestations of every dimension of Byzantine identity – and in particular of collective identity – are language (including culture), religious (and political) commitment, space and time; these phenomena are deeply rooted in human consciousness. This paper deals with the relation between identity and time (temporality). This relation is analysed on the basis of key terms like aion, kairos and chronos and the relations among them; the individualization of temporality becomes manifest in combinations of the mentioned terms with adjectives like emos or hemeteros. Not surprisingly, Byzantine authors – referring to passages in the Old and the New Testament – dealt mainly with eschatological (cosmic) time in relation to individual and collective identity, whereas the interest in the historical dimension of time was limited to authors of a small educated class.
Love and Theatre in the Works of Nikephoros Basilakes
Authors: Kotłowska Anna
Published: April 2020

The article analyzes the rhetorical output of Nikephoros Basilakes, focusing on his use of scenic terminology and the psychological interpretation of myths. The conclusions substantiate the theory that Nikephoros had been part of the imperial theatron before his downfall in the mid-1150s.
Money in the Apophthegmata Patrum
Authors: Milewski Ireneusz
Published: April 2020

The objective of this paper is to discuss accounts related to money in Apophthegmata Patrum, a collection of sayings attributed to famous Egyptian monks. The collection as we know it was produced in the 6th century. By describing the organisation of monastic centres in Egypt in the 4th and 5th century Apophthegmata also offer us some information about the period’s economic aspects. However, by and large, the data is very general. It pertains to: prices, wages, tax issues as well as money that was given to monks by pilgrims. Limited as it is, the data confirms that money was present in the everyday lives of Egyptian monks in late antiquity. Naturally, the major consideration behind whether a monk possessed money was whether he had contact with the outside world. This included selling self-made handcraft at markets, particularly woven mats and ropes, clay pots and sometimes also more specialised items (such as copied codices of the Bible). In Apophthegmata Patrum, similarly to what is the case with other Early Byzantium hagiographic texts, we find little information about moral evaluation of money or about the “appropriate” way to manage it.
The Undying Controversy of the Presence of Slavs on the Island of Crete. Remarks on a New Book by Pantelis Haralampakis
Authors: Kaczyńska Elwira , Witczak Krzysztof Tomasz
Published: April 2020

The paper demonstrates the current state of research on the presence of Slavs on the island of Crete in the Middle Ages, as well as in the modern times. The basis for the discussion is a new book of Pantelis Haralampakis, published in 2016. There are numerous controversies surrounding the issues of the exact chronology of Slavic presence on the island, the lexical influence of South Slavic languages on the Cretan dialect of Modern Greek, as well as possible traces of Slavic settlements in the Cretan toponymy.
Perspectives on Precision Health Among Racial/Ethnic Minority Communities and the Physicians That Serve Them
Authors: Rosas Lisa G. , Nasrallah Catherine , Ta Park Van , Vasquez Jan J. , Duron Ysabel , Garrick Owen , Hattin Riccesha , Cho Mildred , David Sean P. , Evans JIll , McClinton-Brown Rhonda , Martin Christopher
Published: April 2020

Background: In order for precision health to address health disparities, engagement of diverse racial/ethnic minority communi­ties and the physicians that serve them is critical.Methods: A community-based participatory research approach with mixed methods was employed to gain a deeper understanding of precision health research and practice among American Indian, African American, Latino, Chinese, and Vietnamese groups and physicians that serve these communi­ties. A survey assessed demographics and opinions of precision health, genetic testing, and precision health research. Focus groups (n=12) with each racial/ethnic minority group and physicians further explored at­titudes about these topics.Results: One hundred community mem­bers (American Indian [n=17], African American [n=13], Chinese [n=17], Latino [n=27], and Vietnamese [n=26]) and 14 physicians completed the survey and participated in the focus groups. Familiarity with precision health was low among com­munity members and high among physi­cians. Most groups were enthusiastic about the approach, especially if it considered influences on health in addition to genes (eg, environmental, behavioral, social fac­tors). Significant concerns were expressed by African American and American Indian participants about precision health practice and research based on past abuses in bio­medical research. In addition, physician and community members shared concerns such as security and confidentiality of genetic information, cost and affordability of genetic tests and precision medicine, discrimina­tion and disparities, distrust of medical and research and pharmaceutical institutions, language barriers, and physician’s specialty.Conclusions: Engagement of racial/ethnic minority communities and the providers who serve them is important for advancing a precision health approach to addressing health disparities.Ethn Dis. 2020;30(Suppl 1):137-148; doi:10.18865/ed.30.S1.137
Participatory Genomic Testing Can Effectively Disseminate Cardiovascular Pharmacogenomics Concepts within Federally Qualified Health Centers: A Feasibility Study
Authors: Johnson Amber , Broughton Stephen , Aponte-Soto Lisa , Watson Karriem , Da Goia Pinto Carla , Empey Philip , Reis Steven , Winn Robert , Massart Mylynda
Published: April 2020

Objective: We assessed feasibility of an educational program designed to enhance stakeholder knowledge and perceptions of pharmacogenomics at a federally qualified health center (FQHC).Design: FQHCs have a rich history of providing care to the underserved, but often are not represented by studies evaluating cutting-edge concepts. We used a novel educational platform to provide participato­ry genomic testing and classroom education. We assessed participant knowledge and perceptions using questionnaires between May and July 2018.Setting: We partnered with a FQHC affili­ated with an academic medical center in Chicago. Participants: Using convenience sampling, we recruited 20 providers and 10 commu­nity members for a feasibility study. Provid­ers included physicians, physician extend­ers, community health workers, and patient health navigators. Community members were patients, supporters, and/or FQHC advisory board members.Intervention: Participants had the option to undergo personal genomic testing. Online educational modules included basic genet­ics, cardiovascular pharmacogenomics, and personalized medicine. Education conclud­ed in a 2-hour live course with case-based discussions.Main Outcome Measures: Our main out­come was testing pilot feasibility. Baseline knowledge and perceptions were compared with post-intervention assessments using descriptive statistics, t tests (or Wilcoxon rank-sum) for continuous variables and chi-squared (or Fisher’s exact) for categorical variables.Results: We found that attitudes toward the intervention were positive and remained so after intervention. Our intervention was both feasible and acceptable. Genomics knowledge increased for nearly all partici­pants.Conclusions: We have determined that a pharmacogenomics educational program tailored for an underrepresented commu­nity is feasible and acceptable. Outcomes will advise methodology for larger imple­mentation studies. Ethn Dis. 2020;30(Suppl 1):167-176; doi:10.18865/ed.30.S1.167
Machine Learning Methods for Precision Medicine Research Designed to Reduce Health Disparities: A Structured Tutorial
Authors: Basu Sanjay , Faghmous James H. , Doupe Patrick
Published: April 2020

Precision medicine research designed to reduce health disparities often involves studying multi-level datasets to understand how diseases manifest disproportionately in one group over another, and how scarce health care resources can be directed precisely to those most at risk for disease. In this article, we provide a structured tutorial for medical and public health research­ers on the application of machine learning methods to conduct precision medicine research designed to reduce health dispari­ties. We review key terms and concepts for understanding machine learning papers, including supervised and unsupervised learning, regularization, cross-validation, bagging, and boosting. Metrics are reviewed for evaluating machine learners and major families of learning approaches, including tree-based learning, deep learning, and ensemble learning. We highlight the advan­tages and disadvantages of different learning approaches, describe strategies for interpret­ing “black box” models, and demonstrate the application of common methods in an example dataset with open-source statistical code in R.Ethn Dis. 2020;30(Suppl 1):217-228; doi:10.18865/ed.30.S1.217
Stratigraphical reinterpretation of Devonian strata underlying the Mons Basin based on cuttings from the Saint-Ghislain borehole, Hainaut, Belgium
Authors: LICOUR Luciane , GODERNIAUX Pascal , DUPONT Nicolas , HENNEBERT Michel , SWENNEN Rudy , STEEMANS Philippe , BOULVAIN FRÉDÉRIC , PETITCLERC Estelle , RORIVE Alain , BAELE Jean-Marc
Published: April 2020

It is revealed that the lowest 1010 m of the Saint-Ghislain borehole (-4393 to -5403 m), of which cuttings are available, constitutes a crucial source of information to investigate, amongst others, the deep geothermal potential within the Brabant Parautochthon, underlying the Mons Basin, Hainaut. The lithological succession of this interval was reconstructed based mainly on visual analysis and calcimetry of 852 cutting samples as well as four cored sections. Additionally, palynological, magnetic susceptibility and X-ray diffraction analyses were conducted in order to complement the dataset. The lower section of the investigated borehole sequence mainly consists of grey calcareous shale while the middle section is dominated by blue-grey shaly limestone and the upper section is mainly composed of green shale. Palynomorphs found at -5261 m suggest a latest Givetian–Early Frasnian age. A new lithostratigraphical interpretation of the deepest part of the Saint-Ghislain borehole is proposed. The lower calcareous shale from ‑5403 to ‑5100 m is interpreted as the Bovesse Formation (Lower Frasnian) and at its base possibly uppermost Givetian. The overlying limestones from -5100 to -4790 m can be attributed to the Rhisnes Formation (Upper Frasnian), and the green shale between ca. -4393 and -4790 m, to the Bois de la Rocq Member (Famennian). These results open new insights regarding the geological interpretation of the basement underlying the Mons Basin. They also present a promising approach and example regarding interpretations based on cuttings.
LANaPD: Towards a Unified Latin America Natural Products Database
Authors: Medina-Franco José L.
Published: April 2020

Around the World, the number of compound databases of natural products in the public domain is rising. This is in line with the increasing synergistic combination of natural product research and chemoinformatics. Towards this global endeavor, countries in Latin America are assembling, curating, and analyzing the contents and diversity of natural products available in their geographical regions. In this manuscript we collect and analyze the efforts that countries in Latin America have made so far to build natural product databases. We further encourage the scientific community in particular in Latin America, to continue their efforts to building quality natural product databases and, whenever possible, to make them publicly accessible. It is proposed that all compound collections could be assembled into a unified resource called LANaPD: Latin America Natural Products Database. Opportunities and challenges to build, distribute, and maintain LANaPD are also discussed
Contribuições das funções sociais do professor na construção do ser profissional
Authors: Santos Cláudia Santana , Givigi Rosana Carla Nascimento
Published: April 2020

Este artigo objetiva compreender como as múltiplas funções sociais do professor moldam seu exercício profissional. Para tanto, utiliza os construtos da teoria sociológica de Norbert Elias, que parte de sua teoria figuracional, refletindo como as cadeias de interdependências apresentam-se nos contextos escolares com grupos funcionalmente dependentes. Trata-se de um trabalho reflexivo, de base bibliográfica, tendo o alicerce os escritos de Nobert Elias, destacando o Processo Civilizador, A solidão dos moribundos, e A sociedade dos indivíduos, de Norbert Elias, além de artigos e trabalhos publicados que voltem-se ao estudo do autor.  A proposta foi uma reflexão sobre a formação do professor, que antes de assumir a função de docente tem sua ação configurada por uma ideologia social e pessoal. Portanto, a análise das teias de interdependência e das configurações pode dar visibilidade as problemáticas presentes na função do professor e contribuir para que a teia social se equilibre.
Acute Delirium Induced by Ciprofloxacin in a Patient With Chronic Kidney Disease
Authors: Stroud Sarah G. , Kandemir Utku
Published: April 2020

Case:

Ciprofloxacin is increasingly used as oral suppressive therapy for musculoskeletal infections. Delirium and acute hypoglycemia are little-known, severe potential adverse drug reactions. We report here on a patient who experienced both complications. The patient is a 56-year-old woman with no psychiatric history who was managed for left lower extremity chronic osteomyelitis after fracture fixation. She developed significant, prolonged delirium and intermittent hypoglycemia within 24 hours of starting ciprofloxacin; both symptoms remitted within 24 hours of drug discontinuation.

Conclusions:

The neuropsychiatric complications of ciprofloxacin are under-discussed, given its frequency of use, and merit greater awareness for the prevention of postoperative delirium.
GWAS and co-expression network combination uncovers multigenes with close linkage effects on oleic acid content accumulation in Brassica napus
Authors: Yao Min , Guan Mei , Zhang Zhenqian , Zhang Qiuping , Cui Yixin , Chen Hao , Liu Wei , Jan Habib U. , Voss-Fels Kai P. , Werner Christian R. , He Xin , Liu Zhongsong , Guan Chunyun , Snowdon Rod J. , Hua Wei , Qian Lunwen
Published: April 2020

Background: Strong artificial and natural selection causes the formation of highly conserved haplotypes that harbor agronomically important genes. GWAS combination with haplotype analysis has evolved as an effective method to dissect the genetic architecture of complex traits in crop species. Results: We use the 60K Brassica Infinium SNP array to perform a genome-wide analysis of haplotype blocks associated with oleic acid (C18:1) in rapeseed. Six haplotype regions were identified as significantly associated with oleic acid (C18:1) that mapped to chromosomes A02, A07, A08, C01, C02, and C03. Additionally, whole-genome sequencing of 50 rapeseed accessions revealed three genes ( BnmtACP2-A02 , BnABCI13-A02 and BnECI1-A02 ) in the A02 chromosome haplotype region and two genes ( BnFAD8-C02 and BnSDP1-C02 ) in the C02 chromosome haplotype region that were closely linked to oleic acid content phenotypic variation. Moreover, the co-expression network analysis uncovered candidate genes from these two different haplotype regions with potential regulatory interrelationships with oleic acid content accumulation. Conclusions: Our results suggest that several candidate genes are closely linked, which provides us with an opportunity to develop functional haplotype markers for the improvement of the oleic acid content in rapeseed.
A large opening and high flow rate piezoelectric pump with straight arm wheeled check valve
Authors: He Lipeng , Wu Xiaoqiang , Wang Zhe , Zhao Da , Wen Jianming , Tian Xiaochao
Published: April 2020

Piezoelectric pumps are applied in cooling systems of microelectronic devices because of their small size. However, cooling efficiency is limited by low flow rate. A Straight arm wheeled check valve made of silica gel was proposed, which can improve flow rate of piezoelectric pump, solve the influence of glue aging on the sealing ability of a wheeled check valve and reduce the size of piezoelectric pump. This paper discusses the influence of valve arm number (N=2, 3 and 4), valve arm width (W=1.0, 1.2 and 1.4mm) and valve thickness (T=0.6, 0.8 and 1.0mm) on flow rate characteristics of piezoelectric pumps. When valve opening rises, the flow rate increases. The simulation results show that valves with 2 valve arms, 0.6mm valve thickness and 1.0mm valve arm width have maximum valve opening. Experimental results show that piezoelectric pumps with different valve parameters have different optimal frequencies. In addition, maximum flow rate is 431.6mL/min at 220V and 70Hz. This paper provides a reference for the application of piezoelectric pump in cooling system.
Serum uric acid: Association with anthropometric, lipid and complete blood count parameters in Iranian healthy population
Authors: Soori Hamid , Rezapour Parinaz , Najafimehr Hadis , Alirezaei Toktam
Published: April 2020

Objectives A relationship between elevated serum uric acid (SUA) and hypertension, metabolic syndrome and cardiovascular disease has been established. In this study, the relationship of SUA levels and anthropometric measures, serum lipid profile and neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) was examined.Methods Anthropometric parameters including body-mass index (BMI), waist circumference (WC), waist to height ratio(WHtR), waist to hip ratio(W/H), waist to pelvic ratio(W/P), neck circumference(NC), body fat mass(BFM) were obtained, and serum lipid profile containing, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), total cholesterol, triglycerides(TG), also, NLP, PLR, basal metabolic rate (BMR), visceral fat level (VFL) and percent body fat (PBF) were measured among 2921 healthy subjects of young and middle-aged Iranian people. Statistical analysis was performed using SPSS 21 software. To assess the normality of data, the Kolmogorov–Smirnov test was used. Logarithmic transformation was performed for some variables with non-normal distribution. The association between 2 quantitative variables was measured using bivariate correlation (Pearson or Spearman). Pearson correlations and multiple regression analysis were performed to assess the correlation between variables. Simple and multiple regression analyses were performed to predict some variables. P- value <0.05 was considered significant.Results There were 1113 males (mean age, 41.49 ± 8.62 years) and 1808 females (mean age, 42.36 ± 9.07 years) in this study. the male group had a mean SUA level of 4.81± 1.2 mg/dl and the female group had a mean of 4.76 ± 1.1 mg/dl. The results of data analysis showed all studied factors were correlated with SUA level except VFL, BFM, and PLR. The highest correlation was related to skinfold fat thickness, BMR and HDL.Conclusion According to the finding of this study, SUA level measurement might be advisable in healthy population to identify those at increased risk of health problems who might benefit from further evaluation.
University Students’ intention to quit substace abuse in Ethiopian: Application of Theory of Planned Behavior
Authors: gizaw abraham tamirat , Mekuria Misgun Shewangizaw , Abraha Getachew Kiros , Weldemariam Hailemariam Hailesilasie , Gebretsadik Lakew Abebe
Published: April 2020

Background Currently, substance abuse is one of the most burning public health problems in Ethiopia. However, the magnitude of substance abuse and intention to quit is not yet properly studied, Therefore, this study aims to assess University students’ intention to quit substace abuse in Ethiopian:Application of Theory of Planned Behavior (TPB) Methods Institution based cross-sectional study was conducted using self-administered questioners. A stratified sampling technique was used to select the study participants. Descriptive statistics were computed and a multivariate logistic regression model was fitted. A p-value of less than 0.05 was used to declare statistical significance. Result From a total of 392 respondents, 175 (44.6%) were fulfilled the criteria of psychoactive substance abuse (CAGE ≥ 2). Socio-demographic variables such as male respondents (Adjusted Odds Ratio (AOR) =2.34, 95% confidence interval, CI [1.22, 4.51]; P=0.000), Respondents among age category of 25-29 years (Adjusted Odds Ratio(AOR)=21.93, 95% confidence interval CI[16.19; 33.11]; P=0.000) and students with five and above years of study (Adjusted Odds Ratio (AOR)=5.71, 95% confidence interval, CI[2.41-13.52]; P=0.000) had significant association with the psychoactive substance abuse. Theory of Planned Behavior constructs such as positive attitude (Adjusted Odds Ratio[AOR]=1.81,95% confidence interval, CI[1.11,2.96]; P =0.018),supportive Subjective Norm (Adjusted Odds Ratio[AOR]=2.05, 95% confidence interval, CI[1.26,3.47]; P =0.004) and positive Perceived Behavioral Control (Adjusted Odds Ratio [AOR]=6.16, 95% confidence interval, CI[3.75,10.14]; P =0.000) had significant association with quitting psychoactive substance abuse. Conclusion This study illustrated that intention to quit psychoactive substance abuse was predicted by a positive attitude, supportive subjective norm, and positive perceived behavioral control. Therefore, applying health communication strategies focusing on attitude, subjective norm and perceived behavioral control by segmenting students based on sex, age and years of studies are important to bring desired behavioral changes.
USP51, an oncogene for pancreatic cancer (PC) cell growth via Wnt/β-catenin pathway
Authors: Hua Yong-qiang , He Yun , Ding Xiao-bo , Zhang Ke , Sheng Jie , Xu Li-tao , Ning Zhou-yu , Chen Hao , Chen Zhen , Meng Zhi-qiang , Zheng Qing-xing , Liu Lu-Ming
Published: April 2020

Background: Currently, targeting ubiquitin-specific protease (USP) is popular in cancer treatment. Aim: To study the roles of USP51, a member of USPs, in human pancreatic cancer (PC) and the underlying mechanism.Method: Expression of USP51 in tumor pancreatic tissue and PC cell lines were assessed. Overall survival rate of PC patients was measured by Kaplan-Meier method. The association between USP51 and β-catenin in PC cells was determined by Co-Immunoprecipitation (Co-IP) and ubiquitination assay. XAV939 was used to inhibit β-catenin. Protein levels of β-catenin and Cyclin D1 were used to assess the mechanism.Result: Herein, we evidenced high levels of USP51 in tumor tissues of PC patients, which predicted a poor survival. Knockdown of USP51 in MiaPaca2 and SW1990 (two PC cells) inhibited proliferation, arrested MiaPaca2 and SW1990 cells at G0/G1 phases, and impaired tumorigenicity of MiaPaca2 in nude mice, demonstrating the anti-cancer effect of siUSP51 in PC. Moreover, Knockdown of USP51 prevented β-catenin and its downstream Cyclin D1, suggesting the blockade of β-catenin pathway in this process. On the contrary, overexpression of USP51 in ASPC1 (one PC cell) resulted in the opposite effect, facilitating the tumorigenesis of PC and the activation of β-catenin pathway, which were significantly reversed by XAV939. Interestingly, USP51 bound to β-catenin and knockdown of USP51 increased β-catenin ubiquitination.Conclusion: USP51 is an oncogene that is upregulated in PC. USP51 acted as a deubiquitinase that favored β-catenin accumulation, then activated Wnt/β-catenin pathway and exerted carcinogenesis in PC.
Non-destructive Analysis of Volatile Compounds for Geographical Identification of Rice
Authors: Hu Shengying , Ren Hongbo , Yong Song , Gao Siyuan , Meng Li
Published: April 2020

Background In recent years, high-quality rice adulteration has become a serious problem. It is essential to prevent false origin labels and dishonest transactions. However, there is still a lack of rapid identification methods for discriminating rice from different sources. In this study, we developed a method to profile volatile organic compounds (VOCs) using headspace solid phase microextraction (HS-SPME) combined with gas chromatography mass spectrometry (GC-MS). In addition, the identification efficiency of the biomarkers was determined using several multivariate analysis methods. Results Based on the t-test, fold changes and volcano plots, eight typical biomarkers were used based their differential levels. Among them, 2-acetyl-1-pyrroline (2-AP) is the most important source of aroma in rice flavor. Unsupervised analyses, including principal component analysis (PCA) and Cluster analysis, demonstrated the potential for geographic classification of rice between Wuchang and other regions. In addition, partial least squares discriminant analysis (PLS-DA) yielded a goodness of fit of 0.900, a goodness of prediction of 0.853, and a probability of substitution test of 0.012. Random forest (RF) algorithm further strengthened the discriminating ability of volatile compounds. Conclusion In short, the current method can quickly distinguish rice from Wu Chang and other regions, and the research method can facilitate controlling the authenticity and quality of rice.
Cytotoxicity of fractured quartz on human macrophages: role of the membranolytic activity of quartz and phagolysosome destabilization.
Authors: Leinardi Riccardo , Pavan Cristina , Yedavally Harita , Tomatis Maura , Salvati Anna , Turci Francesco
Published: April 2020

Background The pathogenicity of quartz involves lysosomal alteration in alveolar macrophages. This event triggers the inflammatory cascade that may lead to quartz-induced silicosis and eventually lung cancer. Recently, we showed that synthetic quartz induces membrane lysis in red blood cells and cytotoxic responses in murine alveolar macrophages, only when the atomic order of crystal surfaces is upset by fracturing. Cytotoxicity was not observed when quartz exhibited as-grown, unfractured surfaces. These findings raised questions on the potential impact of quartz surfaces on the phagolysosomal membrane upon internalization of the particles by macrophages.Results To gain insights on the surface-induced cytotoxicity of quartz, as-grown and fractured quartz particles in respirable size, differing only in surface properties related to fracturing, were prepared and physico-chemically characterized. Their effects were compared to a well-known toxic commercial quartz dust. Membranolysis was assessed on red blood cells, and quartz uptake, cell viability, and impact on lysosomes were assessed on human PMA-differentiated THP-1 macrophages. All quartz samples were internalized, but only fractured quartz elicited cytotoxicity and phagolysosomal alterations. These effects were blunted when uptake was suppressed. Membranolysis, but not cytotoxicity, was quenched when fractured quartz surface was masked with serum proteins and incubated with cells.Conclusions Upon internalization, the phagolysosome environment rapidly removes serum proteins from quartz surface, restoring quartz membranolytic activity in the phagolysosomes. Fractured quartz induces cytotoxicity in THP-1 human macrophages by promoting phagolysosomal membrane alterations.
Impaired trophoblast Toll-Like Receptor 3 signaling pathway involves in hepatitis B vaccine non- or hypo-response of infants born to HBsAg-positive mothers
Authors: Wu Lina , Zhang Ruijun , Feng Yongliang , Yao Tian , Yi Linzhu , Wan Huili , Li Junli , Feng Shuying , Wang Bo , Wang Suping
Published: April 2020

Background: Babies born to hepatitis B surface antigen (HBsAg) positive mothers bear a high risk of being non- or hypo-responsive to hepatitis B (HB) vaccine with unilluminated mechanisms. Placental immunity is closely related to the development of baby immune system, however, the roles of the placental immunity in the insufficient response of these babies are unclear. This study was aimed to investigate the role of placental trophoblast Toll-Like Receptor 3（TLR3）signaling pathway in HB vaccine non- or hypo-response of these special babies. Methods: A total of 399 pairs of HBsAg-positive mothers and their neonates were recruited to perform a nested case-control study. The maternal and children’s HBV DNA and the HBV serological markers were detected by Fluorescence Quantitative Polymerase Chain Reaction (FQ-PCR) and Electrochemiluminescence Immunoassay (ECLIA). The trophoblast TLR3 signaling pathway proteins and infant cytokines IL-6, IL-12, TNF-α, IFN-α and IFN-γ were tested by immunohistochemistry (IHC) and Enzyme–Linked Immunosorbent Assay (ELISA). Results: The expression of TLR3 and NF-κB, a TLR3 downstream protein, were significantly decreased in the non- or hypo-responders ( Z= -3.00 and -2.46, P <0.01 and =0.01). Furthermore, the trophoblast TLR3 expression negatively correlated with maternal HBV DNA ( r = -0.29, P = 0.003), HBeAg ( r = -0.28, P = 0.01) and HBV DNA+HBeAg ( r = -0.24, P = 0.02). Besides, NF-κB positively correlated with infant IL-6 ( r = 0.24, P = 0.026). By comprehensive analysis of maternal, placental and infant information, a Bayesian network model showed that the trophoblast TLR3 signaling pathway contacted with the non- or hypo-responsiveness. onclusions: Maternal HBV infection affected the trophoblast TLR3 signaling pathway protein expression, and consequently the impaired TLR3 signaling pathway involved in the HB vaccine non- or hypo-responsiveness mainly by influencing infant IL-6.