bluuebunny/crossref_metadata_2025 huggingface dataset:
Modeling and Modulation of NNPC Four-Level Inverter for Solar Photovoltaic Power Plant
Authors: Guo Xiaoqiang , Wang Xuehui , He Ran , Narimani Mehdi
Published: July 2017

Photovoltaic (PV) power plant is an attractive way of utilizing the solar energy. For high-power PV power plant, the multilevel inverter is of potential interest. In contrast to the neutral-point clamped (NPC) or flying capacitor (FC) multilevel inverter, the nested neutral point clamped (NNPC) four-level inverter has better features for solar photovoltaic power plant. In practical applications, the common mode voltage reduction of the NNPC four-level is one of the important issues. In order to solve the problem, a new modulation strategy is proposed to minimize the common mode voltage. Compared with the conventional solution, our proposal can reduce the common mode voltage to 1/18 of the DC bus voltage. Moreover, it has the capability to balance the capacitor voltages. Finally, we carried out time-domain simulations to test the performance of the NNPC four-level inverter.
Evolution of Scale-Free Wireless Sensor Networks with Feature of Small-World Networks
Authors: Duan Ying , Fu Xiuwen , Li Wenfeng , Zhang Yu , Fortino Giancarlo
Published: July 2017

Scale-free network and small-world network are the most impacting discoveries in the complex networks theories and have already been successfully proved to be highly effective in improving topology structures of wireless sensor networks. However, currently both theories are not jointly applied to have further improvements in the generation of WSN topologies. Therefore, this paper proposes a cluster-structured evolution model of WSNs considering the characteristics of both networks. With introduction of energy sensitivity and maximum limitation of degrees that a cluster head could have, the performance of our model can be ensured. In order to give an overall assessment of lifting effects of shortcuts, four placement schemes of shortcuts are analyzed. The characteristics of small-world network and scale-free network of our model are proved via theoretical derivation and simulations. Besides, we find that, by introducing shortcuts into scale-free wireless sensor network, the performance of the network can be improved concerning energy-saving and invulnerability, and we discover that the schemes constructing shortcuts between cluster heads and the sink node have better promoted effects than the scheme building shortcuts between pairs of cluster heads, and the schemes based on the preferential principle are superior to the schemes based on the random principle.
Parallel Multiprojection Preconditioned Methods Based on Subspace Compression
Authors: Moutafis Byron E. , Filelis-Papadopoulos Christos K. , Gravvanis George A.
Published: July 2017

During the last decades, the continuous expansion of supercomputing infrastructures necessitates the design of scalable and robust parallel numerical methods for solving large sparse linear systems. A new approach for the additive projection parallel preconditioned iterative method based on semiaggregation and a subspace compression technique, for general sparse linear systems, is presented. The subspace compression technique utilizes a subdomain adjacency matrix and breadth first search to discover and aggregate subdomains to limit the average size of the local linear systems, resulting in reduced memory requirements. The depth of aggregation is controlled by a user defined parameter. The local coefficient matrices use the aggregates computed during the formation of the subdomain adjacency matrix in order to avoid recomputation and improve performance. Moreover, the rows and columns corresponding to the newly formed aggregates are ordered last to further reduce fill‐in during the factorization of the local coefficient matrices. Furthermore, the method is based on nonoverlapping domain decomposition in conjunction with algebraic graph partitioning techniques for separating the subdomains. Finally, the applicability and implementation issues are discussed and numerical results along with comparative results are presented.
Kawasaki Disease Increases the Incidence of Myopia
Authors: Kung Yung-Jen , Wei Chang-Ching , Chen Liuh An , Chen Jiin Yi , Chang Ching-Yao , Lin Chao-Jen , Lim Yun-Ping , Tien Peng-Tai , Chen Hsuan-Ju , Huang Yong-San , Lin Hui-Ju , Wan Lei
Published: July 2017

The prevalence of myopia has rapidly increased in recent decades and has led to a considerable global public health concern. In this study, we elucidate the relationship between Kawasaki disease (KD) and the incidence of myopia. We used Taiwan’s National Health Insurance Research Database to conduct a population-based cohort study. We identified patients diagnosed with KD and individuals without KD who were selected by frequency matched based on sex, age, and the index year. The Cox proportional hazards regression model was used to estimate the hazard ratio and 95% confidence intervals for the comparison of the 2 cohorts. The log-rank test was used to test the incidence of myopia in the 2 cohorts. A total of 532 patients were included in the KD cohort and 2128 in the non-KD cohort. The risk of myopia (hazard ratio, 1.31; 95% confidence interval, 1.08–1.58; P<0.01) was higher among patients with KD than among those in the non-KD cohort. The Cox proportional hazards regression model showed that irrespective of age, gender, and urbanization, Kawasaki disease was an independent risk factor for myopia. Patients with Kawasaki disease exhibited a substantially higher risk for developing myopia.
miR-202 Suppresses Cell Proliferation by Targeting FOXR2 in Endometrial Adenocarcinoma
Authors: Deng Xinchao , Hou Congzhe , Liang Zhen , Wang Huali , Zhu Lin , Xu Hui
Published: July 2017

Background. MicroRNA-202 (miR-202) has been reported to be aberrantly regulated in several cancers. The aim of this study is to explore the functional role of miR-202 in EAC tumor growth. Material and Methods. miR-202 expression was detected by qRT-PCR. TargetScan and luciferase reporter assay were used to elucidate the candidate target gene of miR-202. The FOXR2 protein level was assessed by Western blot and immunohistochemistry. Survival analysis was explored for FOXR2 expression in EAC patients. Results. miR-202 expression was significantly decreased in EAC tissues (P<0.01) compared with that in control tissues. And the downregulate miR-202 was significantly associated with poor prognosis (P<0.01). Re-expression of miR-202 dramatically suppressed cell proliferation in vitro and tumor growth in vivo. FOXR2 was identified as a direct target of miR-202. In EAC tissues, FOXR2 was upregulated and the increased FOXR2 was significantly associated with poor prognosis. In miR-202-transfected cells, the FOXR2 expression was inversely changed. The analysis of FOXR2 protein expression and miR-202 transcription in EAC tissues showed negative correlation (R=−0.429). Conclusion. miR-202 may function as a tumor suppressor in EAC tumor growth by targeting FOXR2 oncogene, which may provide new insights into the molecular mechanism and new targets for treatment of EAC.
Management of Penetrating Skull Base Injury: A Single Institutional Experience and Review of the Literature
Authors: Zhang Danfeng , Chen Jigang , Han Kaiwei , Yu Mingkun , Hou Lijun
Published: July 2017

Background. Penetrating skull base injury (PSBI) is uncommon among head injuries, presenting unique diagnostic and therapeutic challenges. Although many cases of PSBIs have been reported, comprehensive understanding of its initial diagnosis, management, and outcome is still unavailable. Materials and Methods. A retrospective review was performed for patients treated in neurosurgical department of Changzheng Hospital for PSBIs. Presurgical three-dimensional (3D) Slicer-assisted reconstructions were conducted for each patient. Then we reviewed previous literature about all the published cases of PSBIs worldwide and discussed their common features. Results. A total of 5 patients suffering PSBIs were identified. Penetrating points as well as the surrounding neurovascular structures were clearly visualized, assisting in the presurgical planning of optimal surgical approach and avoiding unexpected vascular injury. Four patients underwent craniotomy with foreign bodies removed successfully and 1 patient received conservative treatment. All of them presented good outcomes after proper management. Conclusion. Careful physical examination and radiological evaluation are essential before operation, and angiography is recommended for those with suspected vascular injuries. 3D modeling with 3D Slicer is practicable and reliable, facilitating the diagnosis and presurgical planning. Treatment decision should be made upon the comprehensive evaluation of patient’s clinicoradiological features and characteristics of foreign bodies.
Learning “How to Learn”: Super Declarative Motor Learning Is Impaired in Parkinson’s Disease
Authors: Marinelli Lucio , Trompetto Carlo , Canneva Stefania , Mori Laura , Nobili Flavio , Fattapposta Francesco , Currà Antonio , Abbruzzese Giovanni , Ghilardi Maria Felice
Published: July 2017

Learning new information is crucial in daily activities and occurs continuously during a subject’s lifetime. Retention of learned material is required for later recall and reuse, although learning capacity is limited and interference between consecutively learned information may occur. Learning processes are impaired in Parkinson’s disease (PD); however, little is known about the processes related to retention and interference. The aim of this study is to investigate the retention and anterograde interference using a declarative sequence learning task in drug-naive patients in the disease’s early stages. Eleven patients with PD and eleven age-matched controls learned a visuomotor sequence, SEQ1, during Day1; the following day, retention of SEQ1 was assessed and, immediately after, a new sequence of comparable complexity, SEQ2, was learned. The comparison of the learning rates of SEQ1 on Day1 and SEQ2 on Day2 assessed the anterograde interference of SEQ1 on SEQ2. We found that SEQ1 performance improved in both patients and controls on Day2. Surprisingly, controls learned SEQ2 better than SEQ1, suggesting the absence of anterograde interference and the occurrence of learning optimization, a process that we defined as “learning how to learn.” Patients with PD lacked such improvement, suggesting defective performance optimization processes.
Double Internal Limiting Membrane Insertion for Macular Hole-Associated Retinal Detachment
Authors: Chen San-Ni , Yang Chung-May
Published: July 2017

Purpose. To describe a modified technique of internal limiting membrane (ILM) insertion for macular hole- (MH-) associated retinal detachment (RD) in highly myopic eyes. Methods. Nine eyes underwent pars plana vitrectomy, cortical vitreous removal, and fovea-sparing ILM peeling. Double ILM insertion into the hole was performed with inverted perifoveal ILM and a free ILM flap followed by air-fluid exchange. Results. Two of the 9 eyes had perifoveal ILM partially torn after cortical vitreous or epiretinal removal. All eyes had the ILM plug stabilized within the MH after double ILM insertion. Postoperatively, MH was sealed with the retina reattached in all the eyes. Conclusion. Double ILM insertion may further secure the ILM flap in place in the eyes with MH-associated RD, especially in cases in which insufficient perifoveal ILM was left. This trial is registered with the clinical registration number Clinicaltrials.gov NCT03174639.
Serum Cytokeratin 18 M30 Levels in Chronic Hepatitis B Reflect Both Phase and Histological Activities of Disease
Authors: Świderska Magdalena , Jaroszewicz Jerzy , Parfieniuk-Kowerda Anna , Rogalska-Płońska Magdalena , Stawicka Agnieszka , Panasiuk Anatol , Flisiak Robert
Published: July 2017

Chronic hepatitis B has highly a dynamic course with significant fluctuations of HBV-DNA and ALT impeding assessment of disease activity. New biomarkers of inflammatory versus noninflammatory stages of HBV infection are urgently needed. Cytokeratin 18 epitope M30 (M30 CK-18) is a sensitive marker of cell death. We aimed to investigate an association between serum M30 CK-18 and histological activity and phase of HBV infection. 150 Caucasian patients with HBV-infection were included in the study. Serum M30 CK-18 levels reflected phase of disease, being significantly higher in both HBeAg(+) and HBeAg(−) hepatitis B in comparison to HBsAg(+) carrier groups. The highest serum M30 CK-18 levels were observed in subjects with the most advanced stages of HBV. Moreover, its serum concentrations correlated with both inflammatory activity and fibrosis advancement (ANOVA P<0.001). Importantly, serum M30 CK-18 levels were able to discriminate patients with mild versus moderate-advanced fibrosis (AUC: 0.86) and mild versus active liver inflammation (AUC: 0.79). M30 CK-18 serum concentration has good sensitivity and specificity in discriminating mild versus moderate/severe fibrosis and inflammation even in patients with normal ALT activity. This study suggests M30 CK-18 as a potential noninvasive marker of disease activity and also a marker of phase of persistent HBV infection.
Barriers of Adherence and Possible Solutions to Nonadherence to Antidiabetic Therapy in Women with Diabetes in Pregnancy: Patients’ Perspective
Authors: Mukona Doreen , Munjanja Stephen Peter , Zvinavashe Mathilda , Stray-Pederson Babil
Published: July 2017

Diabetes in pregnancy contributes to maternal mortality and morbidity though it receives little attention in developing countries. The purpose of the study was to explore the barriers to adherence and possible solutions to nonadherence to antidiabetic therapy in women with diabetes in pregnancy. Antidiabetic therapy referred to diet, physical activity, and medications. Four focus group discussions (FGDs), each with 7 participants, were held at a central hospital in Zimbabwe. Included were women with a diagnosis of diabetes in pregnancy, aged 18 to 49 years, and able to speak Shona or English. Approval was obtained from respective ethical review boards. FGDs followed a semistructured questionnaire. Detailed notes were taken during the interviews which were also being audiotaped. Data were analysed thematically and manually. Themes identified were barriers and possible solutions to nonadherence to therapy. Barriers were poor socioeconomic status, lack of family, peer and community support, effects of pregnancy, complicated therapeutic regimen, pathophysiology of diabetes, cultural and religious beliefs, and poor health care system. Possible solutions were fostering social support, financial support, and improvement of hospital services. Individualised care of women with diabetes is essential, and barriers and possible solutions identified can be utilised to improve care.
Incomplete Resolution of Deep Vein Thromboses during Rivaroxaban Therapy
Authors: Yaghoubian Jonathan M. , Adashek Jacob , Yaghoubian-Yazi Bahareh , Nagar Menachem , Toomari Nojan , Pietras Richard J. , Ben-Zur Uri M.
Published: July 2017

We present the case of a patient with a deep vein thrombosis (DVT) who failed rivaroxaban therapy. Our patient initially presented with left lower extremity edema, erythema, and pain. He was subsequently started on rivaroxaban therapy for a combined treatment period of 12 months, during and after which he persisted to have evidence of a DVT. The patient’s prescribed drug regimen was changed from rivaroxaban to warfarin, which demonstrated a rapid resolution of the DVTs as determined by ultrasound assessment of our patient’s lower extremity veins. Rivaroxaban, a factor Xa inhibitor, is a well-known oral anticoagulant that is used for a variety of indications and has become a mainstay in the treatment of deep vein thrombosis. With the introduction and emergence of this medication in the clinic, postmarketing reports of efficacy or lack thereof are important to review. In conclusion, we anticipate that it is likely that there are other patients with DVTs who may not respond to rivaroxaban and for whom alternative anticoagulation therapies should be explored.
Assessment of Useful Plants in the Catchment Area of the Proposed Ntabelanga Dam in the Eastern Cape Province, South Africa
Authors: Maroyi Alfred
Published: July 2017

Background. The developmental projects, particularly construction of dams, result in permanent changes of terrestrial ecosystems through inundation. Objective. The present study was undertaken aiming at documenting useful plant species in Ntabelanga dam catchment area that will be impacted by the construction of the proposed dam. Methods. A total of 55 randomly selected quadrats were used to assess plant species diversity and composition. Participatory rural appraisal (PRA) methods were used to identify useful plant species growing in the catchment area through interviews with 108 randomly selected participants. Results. A total of 197 plant species were recorded with 95 species (48.2%) utilized for various purposes. Use categories included ethnoveterinary and herbal medicines (46 species), food plants (37 species), construction timber and thatching (14 species), firewood (five species), browse, live fence, and ornamental (four species each), and brooms and crafts (two species). Conclusion. This study showed that plant species play an important role in the daily life and culture of local people. The construction of Ntabelanga dam is, therefore, associated with several positive and negative impacts on plant resources which are not fully integrated into current decision-making, largely because of lack of multistakeholder dialogue on the socioeconomic issues of such an important project.
Neutrophil Extracellular Trap Production in Patients with Colorectal Cancer In Vitro
Authors: Richardson J. J. R. , Hendrickse C. , Gao-Smith F. , Thickett D. R.
Published: July 2017

Purpose. Neutrophil Extracellular Traps (NETs) are extracellular neutrophil derived DNA webs which have been implicated in cancer progression and in the development of metastases. NETs production in patients with colorectal cancer was investigated to elucidate their role and prognostic significance.Methods. Systemic neutrophils were isolated from consecutive patients with colorectal cancer and from age-matched healthy volunteers. Neutrophils were stimulated to produce NETs which were quantified by a measure of the fluorescence of the extracellular DNA. The impact of cancer location, tumour stage, and patient outcomes (complications, length of stay, and mortality) on NET production was investigated.Results. Quantification of NET formation was performed in patients with colorectal cancer (n=45) and in well-matched healthy individuals (n=20). Significant increases in NETs production in response to no stimulant (9,735 AFU versus 11347 AFU,p=0.0209), IL-8 (8,644 AFU versus 11,915 AFU,p=0.0032), and LPS (10,576 AFU versus 12,473 AFU,p=0.0428) were identified in patients with colorectal cancer. A significant increase in NETs production in response to fMLP was detected in patients who developed significant postoperative complications (11,760 AFU versus 18,340 AFU,p=0.0242) and who had a prolonged hospital recovery (9,008 AFU versus 12,530 AFU,p=0.0476). An increase in NETs production was also observed in patients who died, but this did not reach statistical significance. Cancer location and tumour stage did not appear to affect preoperative NETs production.Conclusions. Patients with colorectal cancer have significantly increased NETs production in vitro when compared to healthy volunteers, possibly implicating them in cancer development. Adverse patient outcomes were associated with increased preoperative NETs production, which highlights them as potential therapeutic targets.
Lymphoepithelial Cyst of Parotid in an Immunocompetent Patient with Chronic Otitis Media
Authors: Khadilkar Meera Niranjan , Prasad Vishnu , Santhoor Vijendra Shenoy , Kamath M. P. , Domah Haneesh
Published: July 2017

Lymphoepithelial cysts of parotid are known to occur in HIV patients. In the present report, lymphoepithelial cyst of parotid was diagnosed in a middle aged immunocompetent patient, along with chronic otitis media. The source of infection and treatment options are summarized.
IL-10 and socs3 Are Predictive Biomarkers of Dengue Hemorrhagic Fever
Authors: Flores-Mendoza Lilian Karem , Estrada-Jiménez Tania , Sedeño-Monge Virginia , Moreno Margarita , Manjarrez María del Consuelo , González-Ochoa Guadalupe , Millán-Pérez Peña Lourdes , Reyes-Leyva Julio
Published: July 2017

Background. Cytokines play important roles in the physiopathology of dengue infection; therefore, the suppressors of cytokine signaling (socs) that control the type and timing of cytokine functions could be involved in the origin of immune alterations in dengue.Objective. To explore the association of cytokine andsocslevels with disease severity in dengue patients.Methods. Blood samples of 48 patients with confirmed dengue infection were analyzed. Amounts of interleukins IL-2, IL-4, IL-6, and IL-10, interferon- (IFN-)γ, and tumor necrosis factor- (TNF-)αwere quantified by flow cytometry, and the relative expression ofsocs1andsocs3mRNA was quantified by real-time RT-PCR.Results. Increased levels of IL-10 and socs3 and lower expression ofsocs1were found in patients with dengue hemorrhagic fever (DHF) with respect to those with dengue fever (DF) (p<0.05). Negative correlations were found betweensocs1and both IL-10 andsocs3(p<0.01). The cutoff values ofsocs3(>199.8-fold),socs1(<1.94-fold), and IL-10 (>134 pg/ml) have the highest sensitivity and specificity to discriminate between DF and DHF.Conclusion. Simultaneous changes in IL-10 andsocs1/socs3could be used as prognostic biomarkers of dengue severity.
On Weighted Montgomery Identity for k Points and Its Associates on Time Scales
Authors: Nwaeze Eze R. , Tameru Ana M.
Published: July 2017

The purpose of this paper is to establish a weighted Montgomery identity for k points and then use this identity to prove a new weighted Ostrowski type inequality. Our results boil down to the results of Liu and Ngô if we take the weight function to be the identity map. In addition, we also generalize an inequality of Ostrowski-Grüss type on time scales for k points. For k=2, we recapture a result of Tuna and Daghan. Finally, we apply our results to the continuous, discrete, and quantum calculus to obtain more results in this direction.
Prevalence and Clinical Characteristics of Itch in Vitiligo and Its Clinical Significance
Authors: Vachiramon Vasanop , Onprasert Woranit , Harnchoowong Sarawin , Chanprapaph Kumutnart
Published: July 2017

Objective. Vitiligo usually presented as asymptomatic depigmented macules and patches. Little is known regarding itch in vitiligo. This study aimed to evaluate the prevalence and characteristics of itch in vitiligo patients. Patients and Methods. A cross-sectional study was conducted on vitiligo patients. Itch character and intensity were determined through questionnaires. Evaluation was also made by dermatologists to define vitiligo subtype, body surface area, Koebner phenomenon (KP), and so on. Data were assessed by computer software. Results were considered statistically significant if p<0.05. Results. Among 402 patients, itch on vitiliginous lesion presented in 20.2%. Prevalence of itch was most common in focal vitiligo (29.4%), followed by segmental vitiligo (20.3%) and nonsegmental vitiligo (19.6%), respectively. Tingling sensation was the most common itch-related symptom (82.7%). The median itch intensity is 5 by 10-point visual analog scale. Daily activity and sleep disturbance were observed in 60.5% and 39.5% of patients who experience itch. Itch occurred approximately 3 days prior to the development of lesions in 48.1% of patients. Thirty-two patients (78.1%) with both itch and KP type IIb had active disease. Conclusions. Itch in vitiligo is not uncommon. The presence of itch with KP type IIb may warrant the active vitiligo.
Liver Fibrosis and Hepatitis B Coinfection among ART Naïve HIV-Infected Patients at a Tertiary Level Hospital in Northwestern Tanzania: A Cross-Sectional Study
Authors: Kilonzo Semvua B. , Gunda Daniel W. , Kashasha Flora , Mpondo Bonaventura C.
Published: July 2017

Background. Liver fibrosis which is a common complication of chronic hepatitis B infection is rarely diagnosed in low-resource countries due to limited capacity to perform biopsy studies. Data on the utilization of noninvasive techniques which are feasible for diagnosis of liver fibrosis in these settings among HIV-infected patients is scarce. The objective of this study was to establish the magnitude of liver fibrosis by using both aspartate-aminotransferase-to-platelets ratio and fibrosis-4 scores with associated hepatitis B coinfection among antiretroviral therapy naïve HIV-infected patients. Methods. We reviewed data of 743 adult patients attending HIV clinic with available hepatitis B surface antigen test results. Baseline clinical information was recorded and aspartate-aminotransferase-to-platelet ratio and fibrosis-4 scores were calculated. The cut-off values of 1.5 and 3.25 were used for diagnosis of significant fibrosis by aspartate-aminotransferase-to-platelets ratio and fibrosis-4 scores, respectively. Results. The prevalence of liver fibrosis was 3.5% when aspartate-aminotransferase-to-platelet score was used and 4.6% with fibrosis-4 score and they were both significantly higher among patients with hepatitis B coinfection. Younger patients with HIV advanced disease and elevated liver transaminases had increased risk of having hepatitis B coinfection. Conclusion. A remarkable number of HIV-infected patients present with liver fibrosis, predominantly those with hepatitis B infection.
Switch of Intravitreal Therapy for Macular Edema Secondary to Retinal Vein Occlusion from Anti-VEGF to Dexamethasone Implant and Vice Versa
Authors: Pielen Amelie , Bühler Anima Desiree , Heinzelmann Sonja Ute , Böhringer Daniel , Ness Thomas , Junker Bernd
Published: July 2017

Purpose. To evaluate the anatomical and functional outcome of intravitreal dexamethasone implant for macular edema secondary to central (C) or branch (B) retinal vein occlusion (RVO) in patients with persistent macular edema (ME) refractory to intravitreal antivascular endothelial growth factor (VEGF) treatment compared to treatment naïve patients and to dexamethasone-refractory eyes switched to anti-VEGF. Methods. Retrospective, observational study including 30 eyes previously treated with anti-VEGF (8 CRVO, 22 BRVO, mean age 69 ± 10 yrs), compared to 11 treatment naïve eyes (6 CRVO, 5 BRVO, 73 ± 11 yrs) and compared to dexamethasone nonresponders (2 CRVO, 4 BRVO, 69 ± 12). Outcome parameters were change in best-corrected visual acuity (BCVA) and central foveal thickness (CFT) measured by spectral-domain optical coherence tomography. Results. Mean BCVA improvement after switch to dexamethasone implant was 4 letters (p=0.08), and treatment naïve eyes gained 10 letters (p=0.66), while we noted no change in eyes after switch to anti-VEGF (p=0.74). Median CFT decrease was most pronounced in treatment naïve patients (−437 μm, p=0.002) compared to anti-VEGF refractory eyes (−170 μm, p=0.003) and dexamethasone-refractory eyes (−157, p=0.31). Conclusions. Dexamethasone significantly reduced ME secondary to RVO refractory to anti-VEGF. Functional gain was limited compared to treatment naïve eyes, probably due to worse BCVA and CFT at baseline in treatment naïve eyes.
Prognostic Value of Metastatic Tumoral Caveolin-1 Expression in Patients with Resected Gastric Cancer
Authors: Sun Der Sheng , Hong Soon Auck , Won Hye Sung , Yoo Su Hyun , Lee Han Hong , Kim Okran , Ko Yoon Ho
Published: July 2017

Objective. Caveolin-1 (Cav-1), as the main component of caveolae, has complex roles in tumourigenesis in human malignancies. We investigated Cav-1 in primary and metastatic tumor cells of gastric cancer (GC) and its association with clinical outcomes. Methods. We retrieved 145 cases of GC who had undergone curative gastrectomy. The expression levels of Cav-1 was evaluated by immunohistochemistry, and its association with clinicopathological parameters and patient survival was analyzed. Results. High expression of Cav-1 protein of the GC in the stomach and metastatic lymph node was 12.4% (18/145) and 16.5% (15/91). In the multivariate analysis, tumoral Cav-1 protein in metastatic lymph node showed prognostic significance for relapse-free survival (RFS, HR, 3.934; 95% CI, 1.882–8.224; P=0.001) and cancer-specific survival outcome (CSS, HR, 2.681; 95% CI, 1.613–8.623; P=0.002). Among the GCs with metastatic lymph node, it remained as a strong indicator of poor prognosis for RFS (HR, 3.136; 95% CI, 1.444–6.810; P=0.004) and CSS (HR, 2.509; 95% CI, 1.078–5.837; P=0.032). Conclusion. High expression of tumoral Cav-1 protein in metastatic lymph node is associated with unfavorable prognosis of curative resected GC, indicating the potential of novel prognostic markers.
K-Means Cluster for Seismicity Partitioning and Geological Structure Interpretation, with Application to the Yongshaba Mine (China)
Authors: Shang Xueyi , Li Xibing , Morales-Esteban A. , Dong Longjun , Peng Kang
Published: July 2017

Seismicity partitioning is an important step in geological structure interpretation and seismic hazard assessment. In this paper, seismic event location (X,Y,Z) and Euclidean distance were selected as the K-Means cluster, the Gaussian mixture model (GMM), and the self-organizing maps (SOM) input features and cluster determination measurement, respectively, and 1516 seismic events (M>-1.5) obtained from the Yongshaba mine (China) were chosen for the cluster analysis. In addition, a Silhouette and Krzanowski-Lai- (KL-) combined S-KL index was proposed to obtain the possible optimum cluster number and to compare the cluster methods. Results show that the K-Means cluster obtains the best cluster “quality” with higher S-KL indexes on the whole and meaningful clusters. Furthermore, the optimal number for detailed geological structure interpretation is confirmed as eleven clusters, and we found that two areas probably have faults or caves, and two faults may be falsely inferred by mine geologists. Seismic hazard assessment shows that C5 and C7 (K=11) have a high mean moment magnitude (mM) and C1, C2, C3, and C4 (K=11) have a relatively high mM, where special attention is needed when mining. In addition, C7 (K=11) is the most shear-related area with a mean S-wave to P-wave energy ratio (mEs/Ep) of 41.21. In conclusion, the K-Means cluster provides an effective way for mine seismicity partitioning, geological structure interpretation, and seismic hazard assessment.
Comparison of Sodium Acid Sulfate and UV-C Treatment on Browning and Storage Quality of Fresh-Cut Potatoes
Authors: Xie Yajing , Lin Qiong , Guan Wenqiang , Cheng Shuzhen , Wang Zhidong , Sun Chongde
Published: July 2017

Fresh-cut vegetables, such as potato chips, get brown quickly and can easily be infected by bacterium during storage. Sodium acid sulfate (SAS) and UV-C treatments are regarded as effective methods for food preservation. In this study, the effects of SAS, UV-C treatment, and their combination on fresh-cut potatoes during storage were evaluated. Compared with the control, all of the treatments were effective in inhibiting the bacterial growth during the whole storage period. Also, both SAS and SAS + UV-C treatments significantly decreased browning and polyphenol oxidase (PPO) activity and increased the firmness and malondialdehyde (MDA) contents, while the UV-C treatment has no good effects on protecting such storage qualities in fresh-cut potatoes. However, when compared with SAS treatment, the combination of SAS and UV-C treatment did not promote the effect in protecting the storage abilities. Thus, it was concluded that SAS is a better treatment in extending shelf life and controlling the quality of fresh-cut potatoes during storage compared to UV-C treatment.
Coal Bottom Ash for Portland Cement Production
Authors: Argiz Cristina , Sanjuán Miguel Ángel , Menéndez Esperanza
Published: July 2017

Because of industrialization growth, the amount of coal power plant wastes has increased very rapidly. Particularly, the disposal of coal bottom ash (CBA) is becoming an increasing concern for many countries because of the increasing volume generated, the costs of operating landfill sites, and its potential hazardous effects. Therefore, new applications of coal bottom ash (CBA) have become an interesting alternative to disposal. For instance, it could be used as a Portland cement constituent leading to more sustainable cement production by lowering energy consumption and raw material extracted from quarries. Coal fly and bottom ashes are formed together in the same boiler; however, the size and shape of these ashes are very different, and hence their effect on the chemical composition as well as on the mineralogical phases must be studied. Coal bottom ash was ground. Later, both ashes were compared from a physical, mechanical, and chemical point of view to evaluate the potential use of coal bottom ash as a new Portland cement constituent. Both ashes, produced by the same electrical power plant, generally present similar chemical composition and compressive strength and contribute to the refill of mortar capillary pores with the reaction products leading to a redistribution of the pore size.
Time Evolution of Sublingual Microcirculatory Changes in Recreational Marathon Runners
Authors: Pranskunas Andrius , Arstikyte Justina , Pranskuniene Zivile , Bernatoniene Jurga , Kiudulaite Inga , Vaitkaitiene Egle , Vaitkaitis Dinas , Brazaitis Marius
Published: July 2017

We aimed to evaluate changes in sublingual microcirculation induced by a marathon race. Thirteen healthy male controls and 13 male marathon runners volunteered for the study. We performed sublingual microcirculation, using a Cytocam-IDF device (Braedius Medical, Huizen, Netherlands), and systemic hemodynamic measurements four times: 24 hours prior to their participation in the Kaunas Marathon (distance: 41.2 km), directly after finishing the marathon, 24 hours after the marathon, and one week after the marathon. The marathon runners exhibited a higher functional capillary density (FCD) and total vascular density of small vessels at the first visit compared with the controls. Overall, we did not find any changes in sublingual microcirculation of the marathon runners at any of the other visits. However, in a subgroup of marathon runners with a decreased FCD compared to the subgroup with increased FCD, the subgroup with decreased FCD had shorter running time (190.37±30.2versus221.80±23.4 min,p=0.045), ingested less fluids (907±615versus1950±488 mL,p=0.007) during the race, and lost much more weight (-2.4±1.3versus-1.0±0.8 kg,p=0.041). Recreational marathon running is not associated with an alteration of sublingual microcirculation. However, faster running and dehydration may be crucial for further impairing microcirculation.
Candidate Gene Identification of Feed Efficiency and Coat Color Traits in a C57BL/6J × Kunming F2 Mice Population Using Genome-Wide Association Study
Authors: Miao Yuanxin , Soudy Fathia , Xu Zhong , Liao Mingxing , Zhao Shuhong , Li Xinyun
Published: July 2017

Feed efficiency (FE) is a very important trait in livestock industry. Identification of the candidate genes could be of benefit for the improvement of FE trait. Mouse is used as the model for many studies in mammals. In this study, the candidate genes related to FE and coat color were identified using C57BL/6J (C57) × Kunming (KM) F2 mouse population. GWAS results showed that 61 and 2 SNPs were genome-wise suggestive significantly associated with feed conversion ratio (FCR) and feed intake (FI) traits, respectively. Moreover, the Erbin, Msrb2, Ptf1a, and Fgf10 were considered as the candidate genes of FE. The Lpl was considered as the candidate gene of FI. Further, the coat color trait was studied. KM mice are white and C57 ones are black. The GWAS results showed that the most significant SNP was located at chromosome 7, and the closely linked gene was Tyr. Therefore, our study offered useful target genes related to FE in mice; these genes may play similar roles in FE of livestock. Also, we identified the major gene of coat color in mice, which would be useful for better understanding of natural mutation of the coat color in mice.
Resource Allocation Schemes for Multiple Targets Tracking in Distributed MIMO Radar Systems
Authors: Song Xiyu , Zheng Nae , Bai Ting
Published: July 2017

Considering the demands of different location accuracy for multiple targets tracking, performance-driven resource allocation schemes in distributed MIMO radar system are proposed. Restricted by the tracking antenna number, location estimation mean-square error (MSE), and target priorities, an optimization problem of the minimal antenna subsets selection is modeled as a knapsack problem. Then, two operational schemes, modified fair multistart local search (MFMLS) algorithm and modified fair multistart local search with one antenna to all targets (MFMLS_OAT) algorithm, are presented and evaluated. Simulation results indicate that the proposed MFMLS and MFMLS_OAT algorithm outperform the existing algorithms. Moreover, the MFMLS algorithm can distinguish targets with different priorities, while the MFMLS_OAT algorithm can perform the tracking tasks with higher accuracy.
Integration of Multiple Genomic Data Sources in a Bayesian Cox Model for Variable Selection and Prediction
Authors: Treppmann Tabea , Ickstadt Katja , Zucknick Manuela
Published: July 2017

Bayesian variable selection becomes more and more important in statistical analyses, in particular when performing variable selection in high dimensions. For survival time models and in the presence of genomic data, the state of the art is still quite unexploited. One of the more recent approaches suggests a Bayesian semiparametric proportional hazards model for right censored time-to-event data. We extend this model to directly include variable selection, based on a stochastic search procedure within a Markov chain Monte Carlo sampler for inference. This equips us with an intuitive and flexible approach and provides a way for integrating additional data sources and further extensions. We make use of the possibility of implementing parallel tempering to help improve the mixing of the Markov chains. In our examples, we use this Bayesian approach to integrate copy number variation data into a gene-expression-based survival prediction model. This is achieved by formulating an informed prior based on copy number variation. We perform a simulation study to investigate the model’s behavior and prediction performance in different situations before applying it to a dataset of glioblastoma patients and evaluating the biological relevance of the findings.
Trigeminal Neuralgia, Glossopharyngeal Neuralgia, and Myofascial Pain Dysfunction Syndrome: An Update
Authors: Khan Mohammad , Nishi Shamima Easmin , Hassan Siti Nazihahasma , Islam Md. Asiful , Gan Siew Hua
Published: July 2017

Neuropathic pain is a common phenomenon that affects millions of people worldwide. Maxillofacial structures consist of various tissues that receive frequent stimulation during food digestion. The unique functions (masticatory process and facial expression) of the maxillofacial structure require the exquisite organization of both the peripheral and central nervous systems. Neuralgia is painful paroxysmal disorder of the head-neck region characterized by some commonly shared features such as the unilateral pain, transience and recurrence of attacks, and superficial and shock-like pain at a trigger point. These types of pain can be experienced after nerve injury or as a part of diseases that affect peripheral and central nerve function, or they can be psychological. Since the trigeminal and glossopharyngeal nerves innervate the oral structure, trigeminal and glossopharyngeal neuralgia are the most common syndromes following myofascial pain dysfunction syndrome. Nevertheless, misdiagnoses are common. The aim of this review is to discuss the currently available diagnostic procedures and treatment options for trigeminal neuralgia, glossopharyngeal neuralgia, and myofascial pain dysfunction syndrome.
Low Utilization of Insecticide-Treated Bed Net among Pregnant Women in the Middle Belt of Ghana
Authors: Manu Grace , Boamah-Kaali Ellen Abrafi , Febir Lawrence Gyabaa , Ayipah Emmanuel , Owusu-Agyei Seth , Asante Kwaku Poku
Published: July 2017

Background. Malaria in pregnancy leads to low birth weight, premature birth, anaemia, and maternal and neonatal mortality. Use of insecticide-treated nets (ITNs) during pregnancy is one of the proven interventions to reduce the malaria burden. However, Ghana has not achieved its target for ITN use among pregnant women. Methods. A qualitative study was conducted in seven communities purposively selected from the middle belt of Ghana. Participants who had delivered in the six months prior to this study were selected. In all, seven focus group discussions and twenty-four in-depth interviews were conducted between June and August 2010. Results. Respondents knew of the importance of ITNs and other malaria-preventive strategies. Factors such as financial access and missed opportunities of free distribution denied some pregnant women the opportunity to own or use an ITN. Reasons for not using ITNs during pregnancy included discomfort resulting from heat, smell of the net, and difficulty in hanging the net. Participants maintained their ITNs by preventing holes in the nets, retreatment, and infrequent washing. Conclusion. Pregnant women know about the causes and prevention of malaria. However, this knowledge is not transformed into practice due to lack of access to ITNs and sleeping discomforts among other logistical constraints.
MET18 Deficiency Increases the Sensitivity of Yeast to Oxidative Stress and Shortens Replicative Lifespan by Inhibiting Catalase Activity
Authors: Chen Ya-qin , Liu Xin-guang , Zhao Wei , Cui Hongjing , Ruan Jie , Yuan Yuan , Tu Zhiguang
Published: July 2017

Yeast MET18, a subunit of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery which is responsible for the maturation of Fe/S proteins, has been reported to participate in the oxidative stress response. However, the underlying molecular mechanisms remain unclear. In this study, we constructed a MET18/met18Δ heterozygous mutant yeast strain and found that MET18 deficiency in yeast cells impaired oxidative stress resistance as evidenced by increased sensitivity to hydrogen peroxide (H2O2) and cumene hydroperoxide (CHP). Mechanistically, the mRNA levels of catalase A (CTA1) and catalase T (CTT1) as well as the total catalase activity were significantly reduced in MET18-deficient cells. In contrast, overexpression of CTT1 or CTA1 in MET18-deficient cells significantly increased the intracellular catalase activity and enhanced the resistance ability against H2O2 and CHP. In addition, MET18 deficiency diminished the replicative capacity of yeast cells as evidenced by the shortened replicative lifespan, which can be restored by CTT1 overexpression, but not by CTA1, in the MET18-deficient cells. These results suggest that MET18, in a catalase-dependent manner, plays an essential role in enhancing the resistance of yeast cells to oxidative stress and increasing the replicative capacity of yeast cells.
Missing Teeth and Prosthetic Treatment in Patients Treated at College of Dentistry, University of Dammam
Authors: Fouda Shaimaa M. , Al-Harbi Fahad A. , Khan Soban Q. , Virtanen Jorma I. , Raustia Aune
Published: July 2017

The percentage of completely and partially edentulous patients and their prosthetic treatment at the Department of Substitutive Dental Sciences (SDS), College of Dentistry, University of Dammam, were investigated. Panoramic radiographs and medical records of adult patients (n=479, mean age 45.9 years, and range 25–96 years) treated in 2011–2014 were examined. 6% of the patients were completely edentulous, 8% had single jaw edentulousness, and 74% were partially edentulous. Edentulousness was significantly correlated with age and the number of missing teeth was significantly higher among males (p<0.026). Diabetes was significantly associated with complete edentulousness, single edentulous jaw (p value 0.015), and partial edentulousness (p value 0.023). Kennedy class III was the most frequent class of partial edentulousness in single and/or both jaws (p=0.000). Patients having class I and/or class II were treated most often with removable partial dentures (RPD) (p=0.000), while patients having class III were treated with fixed partial dentures (FPD). It was found that complete edentulousness increases in older age and the number of missing teeth was significantly higher among males. Kennedy class III was most common in both upper and lower jaw and was treated more often with FPD than with RPD.
How Intraday Index Changes Influence Periodontal Assessment: A Preliminary Study
Authors: Bertoldi Carlo , Forabosco Andrea , Lalla Michele , Generali Luigi , Zaffe Davide , Cortellini Pierpaolo
Published: July 2017

It is reputed that periodontal indices remain unchanged over a 24-hour period, with great clinical significance. This preliminary study analyzes daily index changes. In 56 selected patients, full-mouth plaque score (FMPS), full-mouth bleeding score (FMBS), periodontal screening and recording (PSR) indices, and periodontal risk assessment (PRA) were recorded at baseline and three times per day (check-I: 08.30, check-II: 11.30, and check-III: 14.30), after appropriate cause-related therapy. Correlation between variables was statistically analyzed by Stata. All periodontal indices improved at the examination phase. Statistical differences were detected for FMPS comparing all thrice daily checks. Statistical differences were detected for FMBS and PRA comparing check-III with check-I and check-II. PSR showed no significant changes. The worst baseline indices produced the widest daily fluctuation at the examination phase. Significant variation of indices is directly related to clinical severity of periodontal conditions at baseline. Patients affected by severe periodontal disease may show significantly greater index changes. As indices are routinely recorded only once per day, the index daily variation has clinical significance. This greatly affects therapeutic strategy as correct periodontal assessment requires multiple evaluations at standardized times, particularly when baseline conditions are severe.
Stability of Epidoxorubicin Hydrochloride in Aqueous Solutions: Experimental and Theoretical Studies
Authors: Sobczak Agnieszka , Lesniewska-Kowiel Monika A. , Muszalska Izabela , Firlej Artur , Cielecka-Piontek Judyta , Tomczak Szymon , Barszcz Bolesław , Oszczapowicz Irena , Jelińska Anna
Published: July 2017

The first-order degradation kinetics of epidoxorubicin were investigated as a function of pH, temperature, and buffers concentrations. The degradation was followed by HPLC. Buffer catalysis was observed in acetate and phosphate buffers. The pH-rate profiles were obtained at 333, 343, 353, and 363 K. The pH-rate expression was kpH=k1×aH+×f1+k2×f1+k3×f2+(k4×f2+k5×f3)×aOH-, where k1, k4, and k5 are the second-order rate constants (mol−1 L s−1) for hydrogen ion activity and for hydroxyl ion activity, respectively, and k2 and k3 are the first-order constants (s−1) for spontaneous reaction under the influence of water. Epidoxorubicin demonstrates the greatest stability in the pH range 3–5. The electrostatic molecular potential orbitals HOMO-LUMO were also defined in order to determine the cause of the reactivity of particular epidoxorubicin molecule domains in solutions with various pH values.