bluuebunny/crossref_metadata_2025 huggingface dataset:
Hybrid pulmonary artery plication followed by transcatheter pulmonary valve replacement: Comparison with surgical PVR
Authors: Sosnowski Cyndi , Matella Thomas , Fogg Louis , Ilbawi Michel , Nagaraj Hosakote , Kavinsky Clifford , Wolf Andrew R , Diab Karim , Caputo Massimo , Kenny Damien
Published: August 2016

Objective/Background

Historically, the sole option for patients with a dysfunctional native right ventricular outflow tract (RVOT) requiring re‐establishment of pulmonary competence has been surgical PVR. We sought to compare early outcomes of hybrid pulmonary valve replacement (PVR) combining surgical plication of the main pulmonary artery followed by transcatheter PVR, with a contemporary cohort of surgical PVR patients.

Methods

Retrospective chart analysis of all patients with a dilated native RVOT eligible for surgical PVR over 36 months was performed. The cohorts included patients with previous tetralogy of Fallot repair (n = 14), and previous intervention for congenital abnormality of the pulmonary valve (n = 7).

Results

Twenty‐one patients with a dysfunctional native RVOT met criteria for PVR; 8 using the hybrid procedure (group 1: age, 31.5 +/− 17.4 years) and 13 with cardiopulmonary bypass (CPB) (group 2: age, 31 +/− 18.4 years). Valve delivery was successful in all patients with no procedural mortality. Group 1 had a lesser requirement for blood products (P =< 0.001) and a trend toward shorter hospital stay and higher post‐operative hemoglobin. No patients in group 1 received inotropic support post‐operatively compared to 54% of patients in group 2. Mean follow‐up was 3.4 months for group 1 and 13.6 months for group 2 with the average peak gradient across the RVOT of 20.1 and 15.1 mm Hg respectively (P = 0.12), all with no more than mild PI.

Conclusions

Transcatheter hybrid PVR following RVOT plication provides a reasonable alternative to surgical PVR particularly in higher risk cohorts, reducing possible longer‐term consequences of repeated runs of CPB. © 2016 Wiley Periodicals, Inc.
A case of successful Mitraclip implantation in a patient having a large coaptation gap under extracorporeal membrane oxygenation (ECMO)
Authors: Mizote Isamu , Schirmer Johannes , Schäfer Ulrich
Published: August 2016

Mitraclip is an alternative therapeutic option for severe functional mitral regurgitation (MR) with reduced ejection fraction, especially in patients with high surgical risk. Although the Mitraclip was reported as an effective therapy in patients who fulfilled the anatomical criteria of the EVEREST trial, it is still uninvestigated whether the therapy is also feasible and beneficial in patients outside the indication criteria of the EVEREST II trial. Among them, MR with a large coaptation gap is considered as a challenging anatomy, because the gap makes it difficult to grasp both leaflets with a standard Mitraclip procedure. As two techniques to grasp such a large coaptation gap were reported, there was no report concerning the effectiveness of extracorporeal membrane oxygenation (ECMO) during Mitraclip implantation. Here we present a first case of successful Mitraclip implantation in a patient with a large coaptation gap with the support of ECMO. © 2016 Wiley Periodicals, Inc.
Conformational Preferences in Small Peptide Models: The Relevance of cis/trans‐Conformations
Authors: Jangra Harish , Haindl Michael H. , Achrainer Florian , Hioe Johnny , Gschwind Ruth M. , Zipse Hendrik
Published: August 2016

The accurate description of cis/trans peptide structures is of fundamental relevance for the field of protein modeling and protein structure determination. A comprehensive conformational analysis of dipeptide model Ace‐Gly‐NMe (1) has been carried out by using a combination of theoretical calculations and experimental (1H and 13C NMR and NOESY) spectroscopic measurements to assess the relevance of cis‐peptide conformers. NMR measurements in dimethyl sulfoxide (DMSO) solution and calculations employing a continuum solvation model both point to the extended trans,trans conformer C5_tt as the global minimum. The cis‐peptide structures C5_ct and C5_tc, with the N‐ or C‐terminal amide group in cis‐conformation, are observed separately and located 13.0±2 kJ mol−1 higher in energy. This is in close agreement with the theoretical prediction of around 12 kJ mol−1 in DMSO. The ability of common protein force fields to reproduce the energies of the cis‐amide conformers C5_ct and C5_tc in 1 is limited, making these methods unsuitable for the description of cis‐peptide structures in protein simulations.
Gold‐Catalyzed Cyclization of Furan‐Ynes bearing a Propargyl Carbonate Group: Intramolecular Diels–Alder Reaction with In Situ Generated Allenes
Authors: Sun Ning , Xie Xin , Chen Haoyi , Liu Yuanhong
Published: August 2016

Gold‐catalyzed cyclization of various furan‐ynes with a propargyl carbonate or ester moiety results in the formation of a series of polycyclic aromatic ring systems. The reactions can be rationalized through a tandem gold‐catalyzed 3,3‐rearrangement of the propargyl carboxylate moiety in furan‐yne substrates to form an allenic intermediate, which is followed by an intramolecular Diels–Alder reaction of furan and subsequent ring‐opening of the oxa‐bridged cycloadduct. It was found that the steric and electronic properties of phosphine ligands on the gold catalyst had a significant impact on the reaction outcome. In the case of 1,5‐furan‐yne, the cleavage of the oxa‐bridge in the cycloadduct with concomitant 1,2‐migration of the R1 group occurs to furnish anthracen‐1(2H)‐ones bearing a quaternary carbon center. For 1,4‐furan‐yne, a facile aromatization of the cycloadduct takes place to give 9‐oxygenated anthracene derivatives.
ChemInform Abstract: Li4Ge2B as a New Derivative of the Mo2B5 and Li5Sn2 Structure Types.
Authors: Pavlyuk Volodymyr , Ciesielski Wojciech , Rozdzynska‐Kielbik Beata , Dmytriv Grygoriy , Ehrenberg Helmut
Published: August 2016

Single crystals of Li4Ge2B are obtained by solid state reaction of stoichiometric mixtures of the elements (sealed Ta crucible, 1473 K, 15 min; rapid cooling to 25 °C).
ChemInform Abstract: Be2BO3F: A Phase of Beryllium Fluoride Borate Derived from KBe2BO3F2 with Short UV Absorption Edge.
Authors: Guo Shu , Liu Lijuan , Xia Mingjun , Kang Lei , Huang Qian , Li Chao , Wang Xiaoyang , Lin Zheshuai , Chen Chuangtian
Published: August 2016

Single crystals of Be2BO3F are grown by spontaneous nucleation from self‐fluxed high temperature solutions of NaBF4, BeO, B2O3, and LiF in the molar ratio of 1—1.5:1—2:0.5—1.5:1—3 (Pt crucible, 800 °C, 2 d).
ChemInform Abstract: Synthesis, Optical and Thermal Properties of Novel Tb3+ Doped RbCaF3 Fluoroperovskite Phosphors.
Authors: Raja A. , Annadurai G. , Daniel D. Joseph , Ramasamy P.
Published: August 2016

Pure and Tb‐doped RbCaF3 are prepared by sintering stoichiometric amounts of RbF, CaF2, and TbF3 (Al2O3 crucible, 850 °C, 12 h).
ChemInform Abstract: High‐Pressure Control of Vanadium Self‐Intercalation and Enhanced Metallic Properties in 1T‐V1+xS2 Single Crystals.
Authors: Moutaabbid Hicham , Le Godec Yann , Taverna Dario , Baptiste Benoit , Klein Yannick , Loupias Genevieve , Gauzzi Andrea
Published: August 2016

High‐quality 1T‐V1+xS2 (x = 0.09—0.17) single crystals with self‐intercalated V atoms in the van der Waals gap of the layered host are prepared by first reacting a 1:2.1 molar mixture of V and S to achieve single crystalline V5S8 (750 °C, 3 weeks) followed by reaction with 2.05 equivs.
ChemInform Abstract: Cu Insertion into the Mo12 Cluster Compound Cs2Mo12Se14: Synthesis, Crystal and Electronic Structures, and Physical Properties.
Authors: Al Rahal Al Orabi Rabih , Fontaine Bruno , Gautier Regis , Gougeon Patrick , Gall Philippe , Bouyrie Yohan , Dauscher Anne , Candolfi Christophe , Lenoir Bertrand
Published: August 2016

Polycrystalline Cs2CuxMo12Se14 (x = 0, 0.5, 1.0, 1.5, 2.0) phases are prepared by reacting stoichiometric amounts of Cs2Mo6Se8, Mo, and MoSe2 under Ar (sealed Mo crucible, 1573 K, 40 h) followed by reacting Cu powder with the as‐prepared material (evacuated silica tubes, 1173 K, 48 h).
ChemInform Abstract: A Highly Practical Approach to Chiral Homoallylic—Homopropargylic Amines via Aza‐Barbier Reaction.
Authors: Yuan Bin‐Hua , Zhang Zhi‐Cheng , Liu Wen‐Jie , Sun Xing‐Wen
Published: August 2016

Aza‐Barbier reactions of chiral ketimines and allyl bromides afford the title amines with high diastereoselectivity.
ChemInform Abstract: Lewis Base Catalyzed Trialkylsilylcyanide Additions to Cyclic 2‐Fluoroketones: Nucleophile Directed Access to Both cis‐ and trans‐Stereoisomers.
Authors: Brawley Kayla K. , Davis Todd A.
Published: August 2016

Cyclic 2‐fluoroketones react with cyanide (II) and iPr2NEt as the catalyst to give cis‐addition product predominantly, whereas methoxide catalyzed reactions with cyanide (V) favour the formation of trans‐addition products.
ChemInform Abstract: Stereoselective C(sp3)—C(sp2) Bond‐Forming Reactions by Transition‐Metal‐Free Reductive Coupling of Cyclic Tosylhydrazones with Boronic Acids.
Authors: Plaza Manuel , Perez‐Aguilar M. Carmen , Valdes Carlos
Published: August 2016

A diastereoselective reductive alkenylation of tosylhydrazones derived from mono‐substituted cycloalkanones is achieved with alkenylboronic acids without the need for any metal catalyst.
ChemInform Abstract: Regioorientation in the Addition Reaction of α‐Substituted Cinnamonitrile to Enamines Utilizing Chitosan as a Green Catalyst: Unambiguous Structural Characterization Using 2D‐HMBC NMR Spectroscopy.
Authors: Ghozlan Said A. S. , Ahmed Ahmed Gamal , Abdelhamid Ismail Abdelshafy
Published: August 2016

Hexahydroquinolines and their fused derivatives are efficiently prepared in good to excellent yields.
ChemInform Abstract: Intermolecular Homopropargyl Alcohol Addition to Alkyne and a Sequential 1,6‐Enyne Cycloisomerization with Triazole‐Gold Catalyst.
Authors: Hosseyni Seyedmorteza , Wojtas Lukasz , Li Minyong , Shi Xiaodong
Published: August 2016

Utilization of a benzotriazole‐based gold catalyst prevents the known intramolecular cyclization of homopropargylic alcohols (HPAs), allowing for the first intermolecular addition of alkynes to HPAs with subsequent intramolecular enyne cycloisomerization.
ChemInform Abstract: A Hydrazone‐Based exo‐Directing‐Group Strategy for β C—H Oxidation of Aliphatic Amines.
Authors: Huang Zhongxing , Wang Chengpeng , Dong Guangbin
Published: August 2016

A new hydrazone‐based exo‐directing group (DG) strategy is developed for the functionalization of unactivated primary β C—H bonds of aliphatic amines.
ChemInform Abstract: KOtBu‐Initiated Aryl C—H Iodination: A Powerful Tool for the Synthesis of High Electron Affinity Compounds.
Authors: Shi Qinqin , Zhang Siyuan , Zhang Junxiang , Oswald Victoria F. , Amassian Aram , Marder Seth R. , Blakey Simon B.
Published: August 2016

This efficient protocol for iodination of electron‐deficient heterocycles is proposed to rely on a radical reaction initiated by single electron transfer from tBuOK to pentafluoroiodobenzene.
ChemInform Abstract: Metal‐Mediated Debromination of gem‐Dibromoalkenes under Mild Conditions.
Authors: Soengas Raquel G. , Rodriguez‐Solla Humberto , Silva Artur M. S.
Published: August 2016

Depending on the debromination procedure, either E or Z isomers of vinyl bromides are obtained predominantly.
ChemInform Abstract: Catalyst‐Free Aldol Reaction in a Water Medium.
Authors: Yao Weirong , Cui Yanli , Wang Peipei , Mao Yangyi
Published: August 2016

This novel catalyst‐free method uses water as solvent and promoter, proceeds under mild conditions, and gives good yields.
ChemInform Abstract: Direct Olefination of Alcohols with Sulfones by Using Heterogeneous Platinum Catalysts.
Authors: Siddiki S. M. A. Hakim , Touchy Abeda Sultana , Kon Kenichi , Shimizu Ken‐ichi
Published: August 2016

Carbon‐supported Pt nanoparticles (Pt/C) are established as effective heterogeneous catalysts for the direct Julia olefination of alcohols in the presence of sulfones and KOtBu under oxidant‐free conditions.
ChemInform Abstract: Metal‐Free Markovnikov‐Type Alkyne Hydration under Mild Conditions.
Authors: Liu Wenbo , Wang Haining , Li Chao‐Jun
Published: August 2016

Under unprecedented mild conditions using TfOH as the catalyst, a wide range of terminal and internal alkynes are converted into the corresponding ketones.
ChemInform Abstract: One‐Pot Synthesis of Enantiomerically Pure N‐Protected Allylic Amines from N‐Protected α‐Amino Esters.
Authors: Silveira‐Dorta Gaston , Alvarez‐Mendez Sergio J , Martin Victor S , Padron Jose M
Published: August 2016

Enantiomerically pure allylic amines are obtained by an improved one‐pot tandem reduction‐olefination process utilizing N‐protected α‐amino esters derived from natural amino acids.
ChemInform Abstract: 2,2,2‐Trifluoroethyl Oxalates in the One‐Pot Parallel Synthesis of Hindered Aliphatic Oxamides.
Authors: Moroz Yurii S. , et al.
Published: August 2016

Unsymmetrical N1,N2‐substituted aliphatic oxamides (52 examples) are prepared by stepwise aminolysis of methyl(trifluoroethyl)oxalate or bis(trifluoroethyl)oxalate with hindered primary and secondary aliphatic amines, resp., in moderate yields.
ChemInform Abstract: Formamide Synthesis Through Borinic Acid Catalyzed Transamidation under Mild Conditions.
Authors: Dine Tharwat Mohy El , Evans David , Rouden Jacques , Blanchet Jerome
Published: August 2016

An efficient and mild transamidation of amides with amines co‐catalyzed by borinic acid and acetic acid is reported.
ChemInform Abstract: The Addition of Polyfluoroalkanesulfenic Acids to Alkenes.
Authors: Li Xiao‐Bo , Zhao Juan , Jiang Min , Liu Jin‐Tao
Published: August 2016

It is shown that the addition of in situ generated polyfluoroalkanesulfenic acids to non‐cyclic dienes regioselectively affords Markovnikov adducts, whereas Michael‐type adducts are obtained in the reaction of activated alkenes.
ChemInform Abstract: Halogenase‐Inspired Oxidative Chlorination Using Flavin Photocatalysis.
Authors: Hering Thea , Muehldorf Bernd , Wolf Robert , Koenig Burkhard
Published: August 2016

This photocatalytic oxidative chlorination is based on utilization of riboflavin tetraacetate which mimicks an enzymatic process.
ChemInform Abstract: Operationally Simple and Selective One‐Pot Synthesis of Hydroxyphenones: A Facile Access to SNARF Dyes.
Authors: Richter Celin , Ernsting Nikolaus P. , Mahrwald Rainer
Published: August 2016

Compound (VIIb) is used as precursor in the synthesis of SNARF dye (XII).
ChemInform Abstract: Preparations of Saturated N‐P‐N Type Secondary Phosphine Oxides and Their Applications in Cross‐Coupling Reactions.
Authors: Chang Yu‐Chang , Liang Ya‐Han , Hong Fung‐E.
Published: August 2016

Metastable saturated heteroatom‐substituted secondary phosphine oxides, tautomers of the saturated heteroatom‐substituted phosphinous acid, are prepared and utilized as ancillary ligand in Pd‐catalyzed Suzuki—Miyaura cross‐coupling reactions of bromoanisole with phenylboronic acid.
ChemInform Abstract: Eco‐Friendly Suzuki—Miyaura Coupling of Arylboronic Acids to Aromatic Ketones Catalyzed by the Oxime‐Palladacycle in Biosolvent 2‐MeTHF.
Authors: Mondal Manoj , Bora Utpal
Published: August 2016

The use of water unmixable 2‐MeTHF as solvent is an important advantage of the title method, because it provides the easy isolation of the crude reaction mixture just by separation of 2‐MeTHF‐water layers, followed by evaporation of 2‐MeTHF.
ChemInform Abstract: Stereoselective Synthesis of Tricyclic Compounds by Intramolecular Palladium‐Catalyzed Addition of Aryl Iodides to Carbonyl Groups.
Authors: Saadi Jakub , Bentz Christoph , Redies Kai , Lentz Dieter , Zimmer Reinhold , Reissig Hans‐Ulrich
Published: August 2016

Educts (I) bearing a cyclopentanone moiety afford only low amounts of tricycles (II) and (III) (20%, detailed determination of the stereochemistry not possible).
ChemInform Abstract: Synthesis of Dinitrogen‐Fused Spirocyclic Heterocycles via Organocatalytic 1,3‐Dipolar Cycloaddition of 2‐Arylidene‐1,3‐indandiones and an Azomethine Imine.
Authors: Duan Jindian , Cheng Jing , Cheng Yuyu , Li Pengfei
Published: August 2016

An efficient Et3N‐catalyzed 1,3‐dipolar cycloaddition of the title indandiones with pyrazolidine‐based azomethine imines furnishes spiro[indane‐1,3‐dione‐pyrazolidinones] in generally good to high yields with excellent diastereoselectivity under mild conditions.
ChemInform Abstract: Catalytic Asymmetric Prins Bicyclization for the endo‐Selective Formation of 2,6‐Dioxabicyclo[2.2.2]octanes.
Authors: Liu Jie , Zhou Lijun , Wang Chao , Liang Demin , Li Zhiming , Zou Yue , Wang Quanrui , Goeke Andreas
Published: August 2016

A novel FeCl3‐catalyzed bis‐Prins‐cyclization of homoallylic aldehydes (I) and (IV) and the related ketone (VI) with aliphatic and aromatic aldehydes (II) is developed to give 2,6‐dioxabicyclo[2.2.2]octanes in excellent endo‐diastereoselectivity.
ChemInform Abstract: Copper(I)‐Catalyzed Heterocyclization of α‐Acyl‐α‐alkynyl Ketene Dithioacetals: Synthesis of 3‐Cyanofurans.
Authors: Wang Lianjie , Liu Xiaocui , Wang Mang , Liu Jun
Published: August 2016

The heterocyclization procedure generates a cyano moiety in situ with ammonium acetate as the nitrogen source providing 3‐cyanofuran derivatives in good to excellent yield.
ChemInform Abstract: Rhodium‐Catalyzed Tandem Dehydrogenative Coupling—Michael Addition: Direct Synthesis of Phthalides from Benzoic Acids and Alkenes.
Authors: Renzetti Andrea , Nakazawa Hiroshi , Li Chao‐Jun
Published: August 2016

This new method provides access to phthalides by reaction of benzoic acids with vinyl ethyl ketone, methyl acrylate, N,N‐dimethylacrylamide, ethyl and phenyl vinyl sulfones with interesting regio‐ and chemoselectivity though often in moderate yields only.
ChemInform Abstract: Pd(0)‐Catalyzed Dearomative Diarylation of Indoles.
Authors: Petrone David A. , Kondo Masaru , Zeidan Nicolas , Lautens Mark
Published: August 2016

A fully syn‐selective Pd(0)‐catalyzed dearomative indole 1,2‐diarylation is presented by using PtBu3 as the ligand.
ChemInform Abstract: Type 1 Ring‐Opening Reactions of Cyclopropanated 7‐Azabenzonorbornadienes with Organocuprates.
Authors: Carlson Emily , Tam William
Published: August 2016

The ring‐opening provides good to excellent yields of tricyclic γ‐lactams with 1,2‐cis stereochemistry.
ChemInform Abstract: Pd(0)‐Catalyzed Direct C—H Functionalization of 2‐H‐4‐Benzylidene Imidazolones: Friendly and Large‐Scale Access to GFP and Kaede Protein Fluorophores.
Authors: Muselli Mickael , Baudequin Christine , Perrio Cecile , Hoarau Christophe , Bischoff Laurent
Published: August 2016

Palladium‐catalyzed and copper‐assisted direct C2—H arylation and alkenylation of benzylidene imidazolones (available by a one‐pot synthesis) with aryl‐ and alkenylhalides is described.
ChemInform Abstract: A Convenient Synthesis of Bisbenzimidazoles from Iminoester Hydrochlorides via Microwave Technique.
Authors: Kahveci B. , Mentese E. , Oezil M. , Yilmaz F. , Serdar M.
Published: August 2016

The title compounds are prepared by cyclocondensation of diaminobenzidine with several iminoester hydrochlorides of phenylacetic acids in short times and high yields.
ChemInform Abstract: (Enantio)selective Hydrogen Autotransfer: Ruthenium‐Catalyzed Synthesis of Oxazolidin‐2‐ones from Urea and Diols.
Authors: Pena‐Lopez Miguel , Neumann Helfried , Beller Matthias
Published: August 2016

Two different C—O and C—N bonds are sequentially generated with high chemo‐ and regioselectivity by an environmentally benign domino process involving a nucleophilic substitution and alcohol amination.
ChemInform Abstract: Gold(I)‐Catalyzed Intramolecular Hydroarylation and the Subsequent Ring Enlargement of Methylenecyclopropanes to Cyclobutenes.
Authors: Fang Wei , Tang Xiang‐Ying , Shi Min
Published: August 2016

The intramolecular hydroarylation of methylenecyclopropanes containing aryl propargyl ethers gives 2H‐chromene derivatives under mild conditions.
ChemInform Abstract: Cobalt‐Catalyzed Cyclization of N‐Methoxy Benzamides with Alkynes Using an Internal Oxidant Through C—H/N—O Bond Activation.
Authors: Sivakumar Ganesan , Vijeta Arjun , Jeganmohan Masilamani
Published: August 2016

The cyclization of substituted N‐methoxy benzamides with alkynes in the presence of an readily available cobalt complex and NaOAc provides isoquinolone derivatives in good to excellent yields.
ChemInform Abstract: Facile Syntheses of Fluorine‐Containing 4‐Methoxypyrazolo[4,3‐c]quinolines and 6‐Methoxy‐1,4‐diazepino[6,5‐c]quinolines.
Authors: Okada Etsuji , Hatakenaka Mizuki , Adachi Satoru
Published: August 2016

The intramolecular cyclization of dimethylaminoquinoline (I) with various hydrazines is used for the preparation of the title compounds by a chemoselective N‐N exchange reaction.
ChemInform Abstract: Highly Selective Catalytic trans‐Hydroboration of Alkynes Mediated by Borenium Cations and B(C6F5)3.
Authors: McGough John S. , Butler Samuel M. , Cade Ian A. , Ingleson Michael J.
Published: August 2016

Utilization of highly Lewis‐acidic boranes allows for transition metal‐free hydroboration of (hetero)aryl‐ and vinyl substituted terminal alkynes.
ChemInform Abstract: N‐Heterocyclic Carbene—Ytterbium Amide as a Recyclable Homogeneous Precatalyst for Hydrophosphination of Alkenes and Alkynes.
Authors: Yuan Jia , Hu Hongfan , Cui Chunming
Published: August 2016

Three N‐heterocyclic carbene—ytterbium(II) amide complexes are synthesized and characterized.
ChemInform Abstract: Two New Triterpenoids from the Roots of Rhodomyrtus tomentosa.
Authors: Zhang Yu‐Bo , Li Wen , Zhang Ze‐Ming , Chen Neng‐Hua , Zhang Xiang‐Qiang , Jiang Jian‐Wei , Wang Guo‐Cai , Li Yao‐Lan
Published: August 2016

Two new triterpenoids, tomentoids A (Ia) and B (Ib), are isolated from the roots of Rhodomyrtus tomentosa together with five known triterpenoids.
ChemInform Abstract: Readily Accessible Bulky Iron Catalysts Exhibiting Site Selectivity in the Oxidation of Steroidal Substrates.
Authors: Font David , Canta Merce , Milan Michela , Cusso Olaf , Ribas Xavi , Klein Gebbink Robertus J. M. , Costas Miquel
Published: August 2016

Bulky iron complexes are able to catalyze the site‐selective oxidation of alkyl C—H bonds with hydrogen peroxide.
ChemInform Abstract: Flavonoid Glycosides from Siparuna gigantotepala Leaves and Their Antioxidant Activity.
Authors: Torres Castaneda Harlen Gerardo , Colmenares Dulcey Ana Julia , Isaza Martinez Jose Hipolito
Published: August 2016

Two new flavonol glycosides (I) and (II) are isolated from Siparuna gigantotepala leaves along with six known compounds.
ChemInform Abstract: Lasiolactols A and B Produced by the Grapevine Fungal Pathogen Lasiodiplodia mediterranea
Authors: Andolfi Anna , Basso Sara , Giambra Selene , Conigliaro Gaetano , Lo Piccolo Sandra , Alves Artur , Burruano Santella
Published: August 2016

isolation and structure elucidation of lasiolactols A (I) and B (II)
ChemInform Abstract: Chaephilones A and B, Two New Azaphilone Derivatives Isolated from Chaetomium globosum
Authors: Yin Chunping , et al.
Published: August 2016

isolation and structure elucidation of chaephilone A (I) and B (II)
ChemInform Abstract: Functionalization of Two‐Dimensional Transition‐Metal Dichalcogenides
Authors: Chen Xin , McDonald Aidan R.
Published: August 2016

Review: 50 refs.
ChemInform Abstract: Porphyrinic Metal‐Organic Frameworks from Custom‐Designed Porphyrins
Authors: Huh Seong , Kim Sung‐Jin , Kim Youngmee
Published: August 2016

Review: 150 refs.
ChemInform Abstract: Chiral Catalyst Design: Cyclopentadiene‐Based Broensted Acids
Authors: Fleischer Ivana
Published: August 2016

Review: [13 refs.
ChemInform Abstract: Utilization of Isatonic Anhydride in the Syntheses of Various Types of Quinazoline and Quinazolinone Derivatives
Authors: Abbas Samir Y. , El‐Bayouki Khairy A. M. , Basyouni Wahid M.
Published: August 2016

Review: 200 refs.
ChemInform Abstract: Combined Chemo‐Antiinflammatory Prodrugs and Nanoparticles
Authors: Pathak Rakesh K. , Dhar Shanta
Published: August 2016

Review: [43 refs.
ChemInform Abstract: N,N‐Dibromo‐p‐toluenesulfonamide (TsNBr2): A Promising Alternative Bromo‐Organic Reagent
Authors: Rajbongshi Kamal Krishna , Borah Arun Jyoti , Phukan Prodeep
Published: August 2016

Review: [57 refs.
ChemInform Abstract: Ru‐Catalyzed C—H Functionalisations as a Tool for Selective Organic Synthesis
Authors: Ruiz Sara , Villuendas Pedro , Urriolabeitia Esteban P.
Published: August 2016

Review: [37 refs.
ChemInform Abstract: The Evolution of Fe‐Catalyzed Nucleophilic Activation of Acceptor‐Substituted Vinyl‐ and Arylcyclopropanes
Authors: Lin Che‐Hung , Plietker Bernd
Published: August 2016

Review: [32 refs.
ChemInform Abstract: Synthetic Applications of Carbohydrate‐Derived Donor—Acceptor Cyclopropanes
Authors: Ganesh Venkataraman , Sridhar Perali Ramu , Chandrasekaran Srinivasan
Published: August 2016

Review: [24 refs.
ChemInform Abstract: Asymmetric Ring‐Opening Reactions of Donor—Acceptor Cyclopropanes and Cyclobutanes
Authors: Wang Lijia , Tang Yong
Published: August 2016

Review: [21 refs.
ChemInform Abstract: The Annulation of Nitrones and Donor—Acceptor Cyclopropanes: A Personal Account of Our Adventures to Date
Authors: Kerr Michael A.
Published: August 2016

Review: [43 refs.
ChemInform Abstract: All‐Carbon N‐Heterocyclic Carbene‐Catalyzed [3 + 2] Annulation Using Donor—Acceptor Cyclopropanes
Authors: Candish Lisa , Gillard Rachel M. , Fernando Jared E. M. , Levens Alison , Lupton David W.
Published: August 2016

Review: [24 refs.
ChemInform Abstract: Ring‐Opening, Cycloaddition and Rearrangement Reactions of Nitrogen‐Substituted Cyclopropane Derivatives
Authors: Rassadin Valentin A. , Six Yvan
Published: August 2016

Review: 385 refs.
ChemInform Abstract: Broadband Stripline Ferromagnetic Resonance Spectroscopy of Ferromagnetic Films, Multilayers and Nanostructures
Authors: Maksymov Ivan S. , Kostylev Mikhail
Published: August 2016

Review: 239 refs.
ChemInform Abstract: IUPAC‐NIST Solubility Data Series. 102. Solubility of Nonsteroidal Antiinflammatory Drugs (NSAIDs) in Neat Organic Solvents and Organic Solvent Mixtures
Authors: Acree William E.
Published: August 2016

Review: 211 refs.
ChemInform Abstract: Development of Novel Photocatalyst and Cocatalyst Materials for Water Splitting under Visible Light
Authors: Maeda Kazuhiko , Domen Kazunari
Published: August 2016

Review: 112 refs.
ChemInform Abstract: Langmuir‐Blodgett Films of Porphyrins for Applications in Photovoltaics
Authors: Bettini Simona , Valli Ludovico , Giancane Gabriele
Published: August 2016

Review: 49 refs.
ChemInform Abstract: Solvent Effects in Catalysis: Implementation for Modelling of Kinetics
Authors: Murzin Dmitry Yu.
Published: August 2016

Review: 52 refs.
ChemInform Abstract: Gabuda′s Model of Averaging Local Magnetic Fields in Solid‐State NMR. The Mobility of Atoms and Molecules
Authors: Kozlova S. G. , Sergeev N. A. , Buznik V. M.
Published: August 2016

Review: 115 refs.
Rapid identification of Helicobacter pylori and assessment of clarithromycin susceptibility from clinical specimens using FISH
Authors: Demiray‐Gürbüz Ebru , Yılmaz Özlem , Olivares Asalia Z , Gönen Can , Sarıoğlu Sülen , Soytürk Müjde , Tümer Sait , Altungöz Oğuz , Şimşek İlkay , Perez Perez Guillermo I
Published: August 2016

Helicobacter pylori remains one of the most common bacterial infections worldwide. Clarithromycin resistance is the most important cause of H. pylori eradication failures. Effective antibiotic therapies in H. pylori infection must be rapidly adapted to local resistance patterns. We investigated the prevalence of clarithromycin resistance due to mutations in positions 2142 and 2143 of 23SrRNA gene of H. pylori by fluorescence in situ hybridisation (FISH), and compared with culture and antimicrobial susceptibility testing in 234 adult patients with dyspepsia who were enrolled. Antrum and corpus biopsy specimens were obtained for rapid urease test, histopathology and culture. Epsilometer test was used to assess clarithromycin susceptibility. H. pylori presence and clarithromycin susceptibility were determined by FISH in paraffin‐embedded biopsy specimens. We found that 164 (70.1%) patients were positive for H. pylori based on clinical criteria, 114 (69.5% CI 62.5–76.6%) were culture positive, and 137 (83.5% CI 77.8–89.2%) were FISH positive. Thus the sensitivity of FISH was significantly superior to that of culture. However specificity was not significantly different (91.4 versus 100.0%, respectively). The resistance rate to clarithromycin for both antrum and corpus was detected in H. pylori‐positive patients; 20.2% by FISH and 28.0% by E‐test.The concordance between E‐test and FISH was only 89.5% due to the presence of point mutations different from A2143G, A2142G or A2142C. We conclude that FISH is significantly more sensitive than culture and the E‐test for the detection of H. pylori and for rapid determinination of claritromycin susceptibility. The superior hybridisation efficiency of FISH is becoming an emerging molecular tool as a reliable, rapid and sensitive method for the detection and visualisation of H. pylori, especially when the management of H. pylori eradication therapy is necessary. This is particularly important for the treatment of patients with H. pylori eradication failure.
Adaptive eLearning modules for cytopathology education: A review and approach
Authors: Samulski T. Danielle , La Teresa , Wu Roseann I.
Published: August 2016

Clinical training imposes time and resource constraints on educators and learners, making it difficult to provide and absorb meaningful instruction. Additionally, innovative and personalized education has become an expectation of adult learners. Fortunately, the development of web‐based educational tools provides a possible solution to these challenges. Within this review, we introduce the utility of adaptive eLearning platforms in pathology education. In addition to a review of the current literature, we provide the reader with a suggested approach for module creation, as well as a critical assessment of an available platform, based on our experience in creating adaptive eLearning modules for teaching basic concepts in gynecologic cytopathology. Diagn. Cytopathol. 2016;44:944–951. © 2016 Wiley Periodicals, Inc.
Usage trends and performance characteristics of a “gene expression classifier” in the management of thyroid nodules: An institutional experience
Authors: Samulski T. Danielle , LiVolsi Virginia A. , Wong Lawrence Q. , Baloch Zubair
Published: August 2016

Background

The gene expression classifier (GEC; Afirma–Veracyte) has proven to be an effective triage modality in the management of thyroid nodules. We evaluate our institutional experience with GEC, specifically examining performance as a first line testing strategy versus in conjunction with repeat fine needle aspiration (FNA), usage trends based on clinical setting, and performance related to diagnostic categories of The Bethesda System for Reporting Thyroid Cytology (TBSRTC).

Methods

All nodules undergoing GEC analysis from 1/2011 to 12/2015 at the Hospital of the University of Pennsylvania were identified using electronic database search methods. Corresponding cytologic diagnoses, GEC results, origin of the sample (in‐house vs. satellite site), number and diagnosis of prior FNA's, and clinical and histologic follow‐up were collected.

Results

The cohort included 294 nodules. Of these, 145 (49%) were classified as benign, 136 (46%) as suspicious, and 13 (5%) as quantity insufficient by GEC. Surgical resection was performed in 130 (130/294‐44%) cases (107, 82% “suspicious” by GEC); final histopathologic diagnosis was benign in 85 (65%) and malignant in 45 (35%) cases. Three false negative diagnoses were identified in the setting of GEC analysis as a first line testing strategy. Most cases with GEC as a first line testing strategy came from satellite clinical sites (112, 66%).

Conclusions

The GEC showed improved performance characteristics when coupled with a repeat FNA. It continues to be of low specificity and positive predictive value in oncocytic follicular lesions. Diagn. Cytopathol. 2016;44:867–873. © 2016 Wiley Periodicals, Inc.
Glycated albumin and ratio of glycated albumin to glycated hemoglobin are good indicators of diabetic nephropathy in type 2 diabetes mellitus
Authors: Wang Nana , Xu Zhen , Han Ping , Li Tiegang
Published: August 2016

Background

We investigated the association between serum levels of glycated albumin (GA), glycated hemoglobin (HbA1c), and GA:HbA1c ratio and the presence of diabetic nephropathy (DN) in patients with type 2 diabetes mellitus (T2DM).

Methods

Two hundred six consecutive patients with T2DM were enrolled from the endocrinology ward at Shengjing Hospital of China Medical University and classified into 2 groups: DN group (n = 71) and non–diabetic nephropathy (non‐DN) group (n = 135).

Results

The DN group showed significantly higher GA and GA:HbA1c values compared with the non‐DN group. After univariate logistic regression, GA, GA:HbA1c, HbA1c, age, T2DM duration, systolic blood pressure, diastolic blood pressure, triglycerides, mean blood glucose (from 7 blood glucose checks), and presence of retinopathy were selected for advanced analysis. A multivariate logistic regression analysis was performed to examine the association between the presence of DN and these variables. Glycated albumin, GA:HbA1c, duration, systolic blood pressure, mean blood glucose, and retinopathy (but not HbA1c) were identified as independent variables that predicted the presence of DN. We then fitted the areas under the curve of GA:HbA1c and GA (0.811 and 0.754, respectively) separately using a receiver operating characteristic curve analysis. Both were better than HbA1c (0.580). We defined the cutoff value of GA:HbA1c as 2.71 (sensitivity 0.676, specificity 0.778) and that of GA as 17.5% (sensitivity 0.761, specificity 0.644) for the prediction of DN in patients with T2DM.

Conclusions

The GA:HbA1c ratio and GA may be superior to HbA1c associated with the presence of DN.
Stress‐induced peak (but not resting) metabolism correlates with mating display intensity in male guppies
Authors: Biro Peter A. , Fanson Kerry V. , Santostefano Francesca
Published: August 2016

Recent empirical and conceptual papers have highlighted the potential for metabolism to act as a proximate mechanism for behavior that could explain animal personality (consistency over time). Under this hypothesis, individuals with consistently high levels of behavioral activity should also have high resting metabolic rate (RMR) as it can reflect capacity to process food and generate energy. We tested for the predicted positive covariance between RMR and three behaviors that differ in energy demands in 30 male guppies, using multivariate mixed models; we repeatedly measured their activity (10 times each), courtship displays (nine times), voracity (10 times), and metabolism (four‐times). Resting metabolic rate (measured overnight in respirometry trials) did not consistently differ among males, whereas initial peak metabolism measured during those same trials (R = 0.42), and all behaviors were repeatable (R = 0.33–0.51). RMR declined over time suggesting habituation to the protocol, whereas peak metabolism did not. Initial peak metabolism was negatively correlated with courtship display intensity, and voracity was positively correlated with activity, but all other among‐individual correlations were not significant. We conclude that RMR does not provide a proximate explanation for consistent individual differences in behavior in male guppies, and therefore the potential for independent evolution of these physiological and behavioral traits seems possible. Finally, we identify peak metabolism as a potential measure of the stress response to confinement, which highlights the value of considering various aspects of metabolic rates recording during respirometry trials.
Long‐term dynamics in local host–parasite interactions linked to regional population trends
Authors: Ladin Zachary S. , D'Amico Vincent , Baetens Jan M. , Roth Roland R. , Shriver W. Gregory
Published: August 2016

Temporal changes in the relative abundances of host–parasite populations can influence the magnitude of the effects of corresponding interspecific interactions. When parasite populations are at relatively low abundance, the negative effects on host populations may be insignificant, but when parasite abundance increases beyond critical thresholds, they can have population limiting effects on the host. Here, we used data from a 40‐yr demographic study on breeding Wood Thrushes (Hylocichla mustelina) and avian brood parasitic Brown‐headed Cowbirds (Molothrus ater) in the mid‐Atlantic United States to disentangle host–parasite interactions. The relative abundance for these two species has changed both locally and regionally over this time period with a reduction in host abundance coincident with an increase in the parasite population. We detected a fivefold increase in Brown‐headed Cowbird parasitism rates of Wood Thrushes over the 40‐yr time period leading to a reduction in Wood Thrush fitness (i.e., adult survival, fecundity, and recruitment). After accounting for the effects of Wood Thrush age, individual, and annual and within‐season variation in reproduction, we found that Wood Thrushes exhibited increased reproductive effort (produced more nests per year) as nest parasitism rates increased. Additionally, we found that as parasitism rates increased, both Wood Thrush clutch size and fecundity declined. In conjunction with widespread habitat loss and land use change on both wintering and breeding ranges, increasing rates of Brown‐headed Cowbird parasitism are reducing Wood Thrush fitness, and are likely contributing to observed regional Wood Thrush population declines. Coordinated local and regional efforts to reduce Brown‐headed Cowbird populations, particularly in fragmented landscapes, may help reduce the decline for Wood Thrushes, and likely other parasitized Neotropical migratory species.
Patch‐burn grazing increases habitat heterogeneity and biodiversity of small mammals in managed rangelands
Authors: Ricketts Andrew M. , Sandercock Brett K.
Published: August 2016

Habitat heterogeneity is a key driver of biodiversity in many ecosystems. Wildlife inhabiting the native prairies of North America evolved in a heterogeneous mosaic of habitat conditions created by fire and grazing by native ungulates. Current rangeland management practices in the tallgrass prairie ecosystem evenly distribute fire and grazing across management units and promote homogeneous habitat conditions. Patch‐burn grazing is a rangeland management strategy that seeks to restore heterogeneity to rangelands via fire‐grazing interactions. Our 3.5‐year study tested the effects of patch‐burn grazing on habitat heterogeneity and small mammal community dynamics in the Flint Hills ecoregion of eastern Kansas. To study the ecological effects of patch‐burn grazing, we sampled habitat conditions and the small mammal community. We assessed habitat conditions once each growing season in a negative control that was annually burned and grazed, a positive control that was burned every four years and ungrazed, and within each of three units of a patch‐burn grazing experiment (PBG) managed with rotational fire. Habitat conditions were significantly different among treatments, and a principal components analysis showed that the patch‐burn grazing treatment had higher canopy cover of forbs and habitat heterogeneity than our two control units. To sample the small mammal community, we conducted monthly live trapping of small mammals on two randomly located trap grids in each of our two controls and three units of our PBG treatment. Small mammal diversity was significantly higher in the patch‐burn grazing treatment and in the positive control, vs. the negative control. Moreover, a canonical correspondence analysis showed that a fire‐grazing interaction was the major driver structuring small mammal communities. Patch‐burn grazing is an effective strategy for restoring heterogeneity to vegetative structure and composition, and can increase biodiversity of small mammals in managed rangelands in the tallgrass prairie ecosystem.
Water Management Across Borders, Scales and Sectors: Recent developments and future challenges in water policy analysis
Authors: Ingold Karin , Fischer Manuel , de Boer Cheryl , Mollinga Peter P.
Published: August 2016

Integrated water resource management (IWRM) is widely accepted and has been implemented though international, national and regional water management guidelines. Nonetheless, concrete implementation of IWRM gives rise to new questions for policy analysis. Scholars interested in water regulation, the design of effective and efficient policy instruments, and structures of participative and multi‐level policy processes face challenges regarding research design, concepts and empirical approaches. This special issue integrates research about regional, national and transboundary policy perspectives on water management in seven countries, four continents and two transnational water bodies. From the six articles presented in this special issue, we learn more about how to define integration, to think about borders and scales and to theoretically and empirically study collaborative management in water policy analysis. Copyright © 2016 John Wiley & Sons, Ltd and ERP Environment
Transboundary Cooperation in European Water Governance – A set‐theoretic analysis of International River Basins
Authors: Jager Nicolas W.
Published: August 2016

The pursuit of more integrated water resource management based on hydrological boundaries (i.e. river basins) poses significant challenges for domestic environmental governance, let alone in situations where rivers transcend national borders. This paper examines which conditions of governance (and beyond) favour cooperative transboundary river basin management practices under the European Water Framework Directive. This directive, with its detailed procedural provisions for (international) river basin management planning, offers an excellent test bed to investigate and assess the factors and mechanisms of transboundary river basin management. Postulates of neo‐liberal theory of international cooperation, drawn from international relations, help to identify relevant conditions for analysis, covering the two dimensions of state interests and transaction costs. Results of a qualitative comparative analysis show that transaction costs have a strong mitigating influence on the occurrence of cooperative river basin planning. However, reduced transaction costs alone do not suffice for states to enter into cooperation, but the latter have to be activated by a favourable incentive structure, i.e. high problem pressure or legal or domestic incentives. While these insights hold for most cooperative river basin districts, a few basins that follow a contradictory pattern without reduced transaction costs deserve further attention. The findings shed further light on the influence of contextual factors in shaping water governance. Copyright © 2016 John Wiley & Sons, Ltd and ERP Environment
Scale Implications of Integrated Water Resource Management Politics: Lessons from New Zealand
Authors: McNeill Jeffrey
Published: August 2016

Successful integrated water resource management (IWRM) is predicated on increased stakeholder participation and achieving environmental outcomes by locating decision‐making at the catchment scale of management. However, geographic scale impacts opportunities for participation and privileges some actors within the functional and spatial scope of decision‐making. Accordingly, rescaling may merely reconfigure rather than redistribute power. With its dual national and regional management of freshwater based on river catchments, New Zealand's experience of integrated environmental management provides insights for wider theory and practice. In response to recent significant freshwater quality decline from agricultural non‐point discharges over the last two decades and related public concern, the national government and regional councils have redefined participation constellations at national and regional government levels. This paper compares stakeholder diversity and policy effectiveness of regulatory agencies and collaborative initiatives at both national and regional levels, using the Manawatu River catchment as a case study. It detects low participator diversity within regulatory agencies, but relatively high policy salience. In contrast, the collaborative forums' low policy salience, despite their high participator diversity, raises questions about the substantive value of non‐regulatory collaborative initiatives. Copyright © 2016 John Wiley & Sons, Ltd and ERP Environment
Direct Conversion of Aldehydes and Ketones into Azides by Sequential Nucleophilic Addition and Substitution
Authors: Goswami Pratik P. , Suding Victoria P. , Carlson Angela S. , Topczewski Joseph J.
Published: August 2016

This report describes the direct conversion of aldehydes and ketones into alkyl azides by the addition of common organometallic reagents and tandem conversion of the resulting alkoxides without isolation of the intermediate alcohols. A wide range of aldehydes and organometallic reagents (R–Li or R–MgX) are suitable participants in this process. Additional reaction telescoping beyond azide formation is demonstrated.
An Electrochemical Sensor Based on Ni(II) Complex and Multi Wall Carbon Nano Tubes Platform for Determination of Glucose in Real Samples
Authors: Rezaeinasab Masoud , Benvidi Ali , Tezerjani Marzieh Dehghan , Jahanbani Shahriar , Kianfar Ali Hossein , Sedighipoor Maryam
Published: August 2016

In the present paper, a stable and selective non‐enzymatic sensor is reported for determination of glucose (Glc) by using a carbon paste electrode modified with multiwall carbon nanotubes and Ni(II)‐SHP complex as modifier in an alkaline solution. This modified electrode showed impressive activity for oxidation of glucose in NaOH solution. Herein, Ni(II)‐SHP acts as a suitable platform for oxidation of glucose to glucolactone on the surface of the modified electrode by decreasing the overpotential and increasing in the current of analyte. Under the optimum conditions, the rate constant and electron transfer coefficient between electrode and modifier, were calculated to be 1.04 s−1 and 0.64, respectively. The anodic peak currents indicated a linear dependency with the square root of scan rate and this behavior is the characteristic of a diffusion controlled process. So, the diffusion coefficient of glucose was found to be 3.12×10−6 cm2 s−1 due to the used number of transferred electron of 1. The obtained results revealed two linear ranges (5 to 190.0 μM (R2=0.997), 210.0 to 700.0 μM (R2=0.999)) and the detection limit of 1.3 μM for glucose was calculated by using differential pulse voltammetry (DPV) method. Also, the designed sensor was used for determination of glucose in the blood serum and urine samples. Some other advantages of Ni(II)‐SHP/CNT/CPE sensor are remarkable reproducibility, stability and selectivity which can be related to using nanomaterial of carbon nanotubes due to enhancement of electrode surface area.
Anodic Oxidative Disulfide Bond Formation in Egg Protein
Authors: Takahashi Masahito , Handa Akihiro , Kodama Risa , Chiba Kazuhiro
Published: August 2016

Oxidation of thiol groups and formation of disulfide bonds in food protein were achieved via an electrochemical reaction. Iodide acted as a redox mediator and effectively oxidized the thiol groups of the protein. The reaction mechanism was determined through cyclic voltammetry and indicated that indirect oxidation of the thiol group occurred. This anodic oxidation reaction was processed in a mediated fashion and allowed the oxidation of protein, a major macromolecule, without electron transfer involving direct interaction with the surface of the electrode. This reaction can be applied to concentrated ovalbumin or hen egg whites, indicating its usefulness for the food modification industry.