bluuebunny/crossref_metadata_2025 huggingface dataset:
Psychotropic Management in Cotard Syndrome: Case Reports Supporting Dual Medication Management
Authors: Fusick Adam J. , Davis Chemar , Gunther Steven , Klippel Cory , Sullivan Gregory
Published: April 2024

Cotard syndrome is a rare presentation where patients present with nihilistic thoughts of dying or already being dead. These delusions manifest from either a medical or psychiatric etiology and can be difficult to treat. Recently Couto and Gonçalves purposed that treatment should include an atypical antipsychotic alone or in combination with either a mood stabilizer or antidepressant. Here the authors advocate for a more specific but well-known psychotropic regimen, namely the combination of olanzapine and fluoxetine. We conducted a literature review and of 246 papers identified, only three reported using a combination of fluoxetine and olanzapine with many of them having limited or confounding information that make it difficult for us to comment on the historically efficacy of this medication combination. Therefore, the authors provide two case examples of patients being treated successfully with olanzapine and fluoxetine. One, a 66-year-old male veteran and another 76-year-old male veteran. Both of these cases hold significance as the patient’s psychotic depression was so severe as to warrant ECT as a possible treatment. In both cases, this medication combination was able to avoid the procedure. Overall, with the addition of our cases and the sparse information available in the literature, we propose the combination of fluoxetine and olanzapine as an effective Cotard syndrome treatment.
The Investigation of Some Essential Concepts of Extended Fuzzy-Valued Convex Functions and Their Applications
Authors: Allahviranloo T. , Balooch Shahryari M. R. , Sedaghatfar O. , Shahriari M. R. , Saadati R. , Noeiaghdam S. , Fernandez-Gamiz U.
Published: April 2024

In this paper, we are thus motivated to define and introduce the extended fuzzy-valued convex functions that can take the singleton fuzzy values −∞˜ and +∞˜ at some points. Such functions can be characterized using the notions of effective domain and epigraph. In this way, we study important concepts such as fuzzy indicator function and fuzzy infimal convolution for extended fuzzy-valued functions. Finally, we introduce the concept of directional generalized derivative for extended above functions and its properties. Eventually, we give a practical example that will illustrate well the directional g-derivative for the extended fuzzy-valued convex function.
Differential Susceptibility to Propofol and Ketamine in Primary Cultures of Young and Senesced Astrocytes
Authors: Huang Liang , Tuzer Ferit , Murtha Abigail , Green Michael , Torres Claudio , Liu Henry , Malaeb Shadi
Published: April 2024

The adverse effects of general anesthesia on the long-term cognition of young children and senior adults have become of concern in recent years. Previously, mechanistic and pathogenic investigations focused on neurons, and little is known about the effect of commonly used intravenous anesthetics such as propofol and ketamine on astrocytes. Recently, astrocyte dysfunction has been implicated in a wide range of age-related brain diseases. In this study, we examined the survival and viability of both young and senescent astrocytes in culture after adding propofol and ketamine to the media at varying strengths. Oxidative stimulus was applied to commercially available fetal cell lines of human astrocytes in vitro to induce morphological changes in cellular senescence. Our results indicate that propofol reduces the survival of young astrocytes as compared to controls, as well as to ketamine. These effects were seen in comparisons of total cell count and at both high and low dose concentrations. High doses of propofol also significantly reduced cell viability compared to those exposed to baseline controls and ketamine. Senescent astrocytes, on the other hand, demonstrated cell count reductions as compared to baseline controls and ketamine when exposed to either DMSO or propofol. The data show differential susceptibility of young astrocytes to propofol than to ketamine. The observed cell count reduction may be related to the adverse effects of propofol on mitochondrial function and free radical production, as described in previous studies. We speculate that ketamine may have a more favorable safety profile in infants and young children.
Formulation, Process Optimization, and Biochemical Characterization of Cereal-Based Sweet Potato and Mulberry Instant Beverage
Authors: Singh Vishakha , Das Mamoni , Singh Sukh Veer , Sagar Narashans Alok
Published: April 2024

Most of the beverages have a high glycemic index, which is attributed to a sudden rise in blood sugar. The beneficial role of functional foods combination provided the tool to perform and design our study to develop an instant beverage mix (IBM) that might be revealed as the favorable therapeutic potential for the treatment of hyperglycemia and act as a functional beverage. Therefore, resistant fibre-rich ingredients/raw materials were used to formulate the cereal-based instant beverage (CIB). CIB was formulated using black rice flour (40–70%), germinated lentil flour (10–20%), sweet potato flour (10–20%), and mulberry powder (10–20%). The product formulation was optimized with respect to the following responses such as color and appearance, texture, flavor, taste, and overall acceptability using a D-optimal mixture design. The results revealed that the variation in raw ingredients significantly affected the organoleptic properties of trials. The ratio 40 : 20 : 20 : 20 of black rice: germinated lentil: sweet potato: mulberry was found to be optimum for the development of CIB. Optimized CIB had 9.71 ± 0.10 g/100 g of crude protein, 4.73 ± 0.09 g/100 g of fat, and 4.48 ± 0.06 g/100 g of crude fibre. Moreover, the total mineral content and carbohydrate content were found to be 1.08 ± 0.07 g/100 g and 72.45 ± 0.44 g/100 g, respectively, whereas, the energy value was 371.21 ± 4.23 kcal. In vivo glycemic index was also performed for the optimized CIB. The findings showed a lower glycemic response (37.70) than the diabetic control group, and blood glucose was found to be lowered (279.67 ± 20.06 to 227.17 ± 13.44 mg/dL) via the hypoglycemic mechanism. Thus, the optimized CIB exhibited a therapeutic effect against diabetic conditions and might be a healthy instant beverage for human consumption.
Impact of Surgery-Induced Myeloid-derived Suppressor Cells and the NOX2/ROS Axis on Postoperative Survival in Human Pancreatic Cancer
Authors: Grauers Wiktorin Hanna , Aydin Ebru , Kiffin Roberta , Vilhav Caroline , Bourghardt Fagman Johan , Kaya Mustafa , Paul Sanchari , Westman Beatrice , Bratlie Svein Olav , Naredi Peter , Hellstrand Kristoffer , Martner Anna
Published: April 2024

Preclinical studies imply that surgery triggers inflammation that may entail tumor outgrowth and metastasis. The potential impact of surgery-induced inflammation in human pancreatic cancer is insufficiently explored. This study included 17 patients with periampullary cancer [pancreatic ductal adenocarcinoma (PDAC) n = 14, ampullary carcinoma n = 2, cholangiocarcinoma n = 1] undergoing major pancreatic cancer surgery with curative intent. We analyzed the potential impact of preoperative and postoperative immune phenotypes and function on postoperative survival with >30 months follow-up. The surgery entailed prompt expansion of monocytic myeloid-derived suppressor cells (M-MDSC) that generated NOX2-derived reactive oxygen species (ROS). Strong induction of immunosuppressive M-MDSC after surgery predicted poor postoperative survival and coincided with reduced functionality of circulating natural killer (NK) cells. The negative impact of surgery-induced M-MDSC on survival remained significant in separate analysis of patients with PDAC. M-MDSC–like cells isolated from patients after surgery significantly suppressed NK cell function ex vivo, which was reversed by inhibition of NOX2-derived ROS. High NOX2 subunit expression within resected tumors from patients with PDAC correlated with poor survival whereas high expression of markers of cytotoxic cells associated with longer survival. The surgery-induced myeloid inflammation was recapitulated in vivo in a murine model of NK cell–dependent metastasis. Surgical stress thus induced systemic accumulation of M-MDSC–like cells and promoted metastasis of NK cell–sensitive tumor cells. Genetic or pharmacologic suppression of NOX2 reduced surgery-induced inflammation and distant metastasis in this model. We propose that NOX2-derived ROS generated by surgery-induced M-MDSC may be targeted for improved outcome after pancreatic cancer surgery.

Significance:

Pancreatic cancer surgery triggered pronounced accumulation of NOX2+ myeloid-derived suppressor cells that inhibited NK cell function and negatively prognosticated postoperative patient survival. We propose the targeting of M-MDSC as a conceivable strategy to reduce postoperative immunosuppression in pancreatic cancer.
Systemic Co-Administration of Low-Dose Oxytocin and Glucagon-Like Peptide 1 Additively Decreases Food Intake and Body Weight
Authors: Maejima Yuko , Yokota Shoko , Hidema Shizu , Nishimori Katsuhiko , de Wet Heidi , Shimomura Kenju
Published: April 2024

Introduction: GLP-1 receptor agonists are the number one drug prescribed for the treatment of obesity and type 2 diabetes. These drugs are not, however, without side effects, and in an effort to maximize therapeutic effect while minimizing adverse effects, gut hormone co-agonists received considerable attention as new drug targets in the fight against obesity. Numerous previous reports identified the neuropeptide oxytocin (OXT) as a promising anti-obesity drug. The aims of this study were to evaluate OXT as a possible co-agonist for GLP-1 and examine the effects of its co-administration on food intake (FI) and body weight (BW) in mice. Methods: FI and c-Fos levels were measured in the feeding centers of the brain in response to an intraperitoneal injection of saline, OXT, GLP-1, or OXT/GLP-1. The action potential frequency and cytosolic Ca2+ ([Ca2+]i) in response to OXT, GLP-1, or OXT/GLP-1 were measured in ex vivo paraventricular nucleus (PVN) neuronal cultures. Finally, FI and BW changes were compared in diet-induced obese mice treated with saline, OXT, GLP-1, or OXT/GLP-1 for 13 days. Results: Single injection of OXT/GLP-1 additively decreased FI and increased c-Fos expression specifically in the PVN and supraoptic nucleus. Seventy percent of GLP-1 receptor-positive neurons in the PVN also expressed OXT receptors, and OXT/GLP-1 co-administration dramatically increased firing and [Ca2+]i in the PVN OXT neurons. The chronic OXT/GLP-1 co-administration decreased BW without changing FI. Conclusion: Chronic OXT/GLP-1 co-administration decreases BW, possibly via the activation of PVN OXT neurons. OXT might be a promising candidate as an incretin co-agonist in obesity treatment.
Prestação de serviços à comunidade de caráter coletivo e territorial: potências, referenciais teóricos e desafios desta estratégia metodológica
Authors: Vedovello Adilaine Juliana Scarano , Galheigo Sandra Maria
Published: April 2024

O estudo teve como enfoque a medida socioeducativa de Prestação de Serviços à Comunidade (PSC), cujo objetivo geral foi sistematizar a estratégia metodológica da PSC COLETIVA, em seus aspectos históricos, processos, referências teóricas e experiências. Utilizou-se pesquisa documental, entrevistas com atores relevantes à implementação da proposta e grupo focal com profissionais do serviço. A análise indicou a existência de duas fases no desenvolvimento da metodologia estudada, sendo a segunda redenominada de PSC COLETIVA E TERRITORIAL (PSC-CT), que se tornou o foco do estudo, pois sua proposta favorece a construção coletiva, participativa e territorial da PSC, trazendo novos sentidos para os processos de engajamento, responsabilização e transformação vividos pelos adolescentes no cumprimento da medida. Seus eixos centrais são: a atividade como principal recurso de mediação, o trabalho grupal, a ação territorial e o acompanhamento familiar. A PSC-CT se sustenta na socioeducação, com um efetivo trabalho educativo e pedagógico, crítico e participativo, na perspectiva da garantia de direitos para os adolescentes autores de atos infracionais. Esta proposta metodológica pode ser considerada uma tecnologia social que contribui para o campo das medidas socioeducativas em meio aberto no Brasil e fortalece o trabalho da terapia ocupacional no Sistema Único de Assistência Social.
Problematização de saberes e práticas na terapia ocupacional brasileira: a construção do pensamento crítico entre 1979 e 1996
Authors: Galheigo Sandra Maria
Published: April 2024

: This article proposes to present, in a descriptive and analytical way, the historical constitution of critical thinking in Brazilian occupational therapy between 1979 and 1996. It is a theoretical and historical research, which took as its object some key discussions on historical-epistemological foundations of occupational therapy through a reflective and critical reading of texts. The study made use of the previous research database on the national occupational therapy literature from 1956 to 2017 through a scoping review. Books, master's dissertations, abstracts from scientific event annals and articles from national occupational therapy journals were used. The descriptive and analytical presentation of the results is organized into three distinct periods: (i) emergence of the first counter-hegemonic records at the end of the 1970s, published in event annals; (ii) production of critical studies in historical-epistemological foundations, published in master's dissertations and books from 1987 to 1990 and; (iii) critical elaborations on the hegemonic biomedical thought, the institutionalizaton of people and the technical-procedural model, published in occupational therapy journals from 1990 to 1993/6. The historical period between 1979 and 1996 marks the emergence of critical thinking in Brazilian occupational therapy. These elaborations contributed to make visible a certain ethical-political position that would serve as a foundation for the emancipatory practices that would happen in the following decade.
O brincar e a cultura popular: reflexões para a Terapia Ocupacional
Authors: Batista Marina Fenício Soares , Lima Elisabeth Maria Freire de Araújo
Published: April 2024

Considerando o brincar como atividade humana, este artigo traz uma reflexão sobre as relações entre o brincar, asbrincadeiras tradicionais, a cultura popular e a terapia ocupacional, na busca por ampliar perspectivas no fazer terapêutico e na participação social de crianças e jovens. Parte-se do pressuposto de que o brincar é um fazer criativo, e que a perspectiva popular traz como proposta fundante a relação desse fazer com a ancestralidade cultural de povos historicamente oprimidos e subalternizados, que buscam em sua expressão combater a cultura do silêncio impostas pelas classes dominantes. A abordagem da Terapia Ocupacional para o brincar e as brincadeiras proposta aqui considera aspectos sociais, ambientais e valores do universo lúdico no desenvolvimento da prática, buscando contribuir para processos terapêuticos que explorem com as crianças seu relacionamento com o mundo e as conexões em esferas subjetivas que estão se movendo, fluindo, se articulando a valores que confrontam os processos hegemônicos de consumo, homogeneização e subalternização.
Linguagens em diálogo
Authors: Salles Cecília Almeida
Published: April 2024

O artigo discute a relação entre as linguagens visual e verbal nos processos criativos do escritor Ignácio de Loyola Brandão e do artista plástico Daniel Senise. A partir do acompanhamento da estruturação da trama semiótica, podem-se observar modos diferentes de funcionamento de pensamentos em criação.
Crítica genética e história literária
Authors: Willemart Philippe
Published: April 2024

Objeto de uma conferência para não iniciados em crítica genética, o texto que segue conceitua num primeiro momento essa nova abordagem dos textos e dos manuscritos lembrando as circunstâncias de seu nascimento na França e no Brasil e como ela é resultado do trabalho de escritores-autores, de críticos, de arquivistas e do contexto intelectual e político na época. Em seguida, defino um novo conceito de história literária decorrente dessa constatação para, enfim, determinar qual é o impacto da crítica genética na história da literatura e na relação do pesquisador com os arquivos.
O grito da poética da criação – resumo da tese A escritura e a ficção da escritura
Authors: Pino Claudia Amigo
Published: April 2024

Neste artigo, empreendo a sempre frustrante tarefa de resumir uma tese de doutorado. A tese em questão é “A escritura da ficção e a ficção da escritura: sobre o romance 53 jours, de Georges Perec”, orientada por Philippe Willemart e defendida na área de Língua e Literatura Francesa da Universidade de São Paulo no dia 18 de dezembro de 2001. O artigo abordará as diferentes etapas da pesquisa: uma descrição da crítica e da literatura do processo) a proposta de uma estética da criação) a gênese do romance e uma interpretação dos diferentes movimentos de escritura.
A gênese de Maternítat: schemata e mudança em Miró
Authors: Meurer Sérgio José
Published: April 2024

O texto analisa esboços realizados pelo pintor Joan Miró para o quadro Maternitat (1923-1924), verificando as possibilidades compositivas testadas pelo pintor. Ao atingir a economia de elementos da linguagem visual, verifica-se alteração de “schemata” de Miró em meio aos documentos de processo, bem como o realce de formas e figuras que se coadunam com o tema do quadro.
Manuscritos do modernista Luís Aranha
Authors: Machado Márcia Regina Jaschke
Published: April 2024

A observação da série "Manuscritos de vários escritores” no Arquivo de Mário de Andrade, mostra não apenas textos de muitos brasileiros e de alguns estrangeiros, produzidos entre 1917 e 1945, contendo nas rasuras marcas do processo criativo desses mesmos textos, mas revela, nas notas de margem deixadas pelo autor de Macunaíma, determinados passos de trabalhos seus de crítica literária. Ambas as intervenções, que enriquecem e particularizam este conjunto documental, podem ser testemunhadas no manuscrito Cocktail do poeta modernista Luís Aranha.
Brazilian flashes parade in Bishop's manuscripts
Authors: Anastácio Silvia Maria Guerra
Published: April 2024

O processo de criação do poema “Under the window: Ouro Preto” reflete uma forte marca de visualidade, que se evidencia em seus manuscritos e que tão bem reflete os problemas socioeconômicos do Brasil.
Escritura Hermiliana: uma aventura transtextual
Authors: Lima Sônia Maria van Dijck
Published: April 2024

Sem resumo.
A A Reelaboração de Textos Publicados na Revista "O Cruzeiro"
Authors: Rabello Adylla Rocha
Published: April 2024

In this study we present the reelaboration of the discourse of "Sem me ri, sem chorar", "crônicas" published by José Américo de Almeida in CRUZEIRO magazine, Rio de Janeiro, 1957. To show this process, we made use of fragments of three chronicles that best exemplify it because they show the various types of changes that characterize the new writing of these texts.
A Escritura em Processo: Um Estudo Genético: o caso de "Gaetaninho", de Alcântara Machado
Authors: Perez Celso Martinez
Published: April 2024

Basing ourselves on the genetic study of the first autograph page of the shortstory "Gaetaninho", it is our intention to understand how the writing process is accomplished, by means of analysing the elements which have been added and deleted by Alcântara Machado.
Fenômenos Físicos e Fenômenos Literários: aproximações
Authors: Willemart Philippe
Published: April 2024

Este artigo retoma as conclusões do curso oferecido em pós-graduação sobre o nascimento do texto. Uma física amplia a visão que temos de Newton. Um físico expõe a teoria do caos e da auto-organização. Um especialista em Joyce discerne certos procedimentos de criação e o autor tenta articular a teoria literária com a visão "física" encontrando nela novos conceitos operacionais.
A Construção do Mal-estar: uma leitura da gênese do conto "A bela e a fera ou A ferida grande demais" de Clarice Lispector
Authors: Magalhães Luiz Antonio M.
Published: April 2024

The literary criticism has always emphasized the intuitive aspect of Clarice Lispector's writing, denying the detailed construction of her texts, that were, in this perspective, the result of a process of montage. This view is due to the fact that her writing procedures were basically fragmentary and without a previous plan. This article intends to show that, despite being possible to classify Clarice's creation as a "writing as a process" — according to the distinction established by Louis Hay — some of the essential characteristics of her work — such as the "moment of epiphany" — turn out by means of changes in the text fixed in an initial phase. This process can be seen in the analysis of fragments of the short story "A bela e a fera ou A ferida grande demais".
Illustrations II, da madrugada à aurora
Authors: Perrone-Moisés Leyla
Published: April 2024

Este artigo é uma análise dos rascunhos de Illustrations II, de Michel Butor, obra composta de textos anteriormente publicados, retomados e interligados de modo novo Essa análise revela que os procedimentos de integração dos textos: supressão, deslocamento, condensação, recomposição gráfica e as etapas de transformações indicadas pelos três tipos de escrita: datilografia, tinta azul e lápis preto, foram análogos na maior parte do livro. Reescritura ou auto-reciclagem, aspecto particular da intertextualidade, as operações realizadas neste manuscrito remetem a conceitos-chave do projeto butoriano: inacabamento, prosseguimento, construção, aperfeiçoamento, variação e diálogo.
Aspectos da gênese de deus e o diabo na terra do sol
Authors: Monzani Josette M. A. Souza
Published: April 2024

The text presents, first, some aspects related to the gathering and organization of the different versions of Glauber Rocha’s screenplay for his film Deus e o Diabo na Terra do Sol. It discusses, also, the development of the characters of this narrative in its different levels.
Louis Hay y la memoria de los signos: "el movimiento de lescritura y las tensiones del proceso cultural"
Authors: Lois Élida
Published: April 2024

Sem resumo.
Olhar sobre o encontro gênese e memória
Authors: Willemart Philippe
Published: April 2024

Sem resumo.
Da natureza complexa da produção de um texto
Authors: Macedo Lino de
Published: April 2024

Sem resumo
O processo de criação em Incidente em Antares
Authors: Silva Márcia Ivana de Lima
Published: April 2024

O artigo apresenta os resultados de um estudo em crítica genética, a partir da análise dos manuscritos de Érico Veríssimo para seu Livro Inci­dente em Antares. O estudo genético teve como instrumentalização teóri­ca as teses de Mikhail Bakhtin sobre a- linguagem, por meio das quais buscou-se identificar a intencionalidade da escolha vocabular do escri­tor; assim como revelar as bases polifônicas e heteroglóssicas dos passos de seu processo compositivo.
Le manuscrit pluriel et polymorphe
Authors: Ferrer Daniel
Published: April 2024

O que faz os manuscritos de criação artística a fonte de questões inesgotáveis é a densidade incomparável de informações que eles guardam. Essa densidade, que se apoia sobre aquela que caracteriza a obra de arte acrescentando componentes próprios, resulta de uma pluralidade semiótica: onde se entrecruzam sistemas múltiplos de sentido que coope­ram e se contradizem, símbolos, ícones e índices, diagramas, partituras e scripts que se misturam; de uma pluralidade enunciativa: aquém do “fal­so” (Valéry) da obra acabada, escondendo, sob uma coerência fictícia, a multiplicidade de pontos de vista sucessivos, percebe-se uma subjetividade atomizada ao mesmo tempo que se encaminha em direção a uma unifi­cação ortopédica - de uma pluralidade ou no mínimo de uma instabilida­de axiológica: e o laboratório onde pode-se observar minuciosamente uma faceta essencial da construção do valor estético. Em que medida essas características são encontradas fora do manus­crito literário? Se a pluralidade semiótica é fácil de ser encontrada em outros espaços, a pluralidade enunciativa é menos evidente, quanto a instabilidade do sistema de valores estéticos, seria necessário determinar aquilo a que poderia corresponder.
Por uma fisiologia do deslumbramento em “No caminho de Swann” e “O tempo redescoberto” de Marcel Proust
Authors: Zular Roberto
Published: April 2024

A fisiologia do deslumbramento pretende sustentara hipótese de uma forte analogia entre corpo e escritura na obra de Marcel Proust, partindo do jogo das memórias (do escritor, do leitor, do narrador) e sua articula­ção pelo operador da escritura tal como conceituado por Philippe Willeinart. Por fim, expandiremos nossa hipótese relacionando a prosa proustiana com a música de Debussy e a pintura de Cézanne.
O manuscrito do leitor Mário de Andrade
Authors: Christini Beatriz Protti , Tokimatsu Rosana Fumie
Published: April 2024

Este artigo apresenta o método de trabalho desenvolvido para organi­zação e exploração da Marginãlia Apensa do Arquivo Mário de Andrade. Aborda as notas de leitura do escritor, autógrafos em folhas avulsas en­contradas no interior de livros de sua biblioteca. Essas notas de Mário par­ticipam, muitas vezes, do percurso genético de ensaios seus. A Marginalia Apenas inclui também manuscritos de outros autores brasileiros.
A margem da carta
Authors: Galvão Walnice Nogueira
Published: April 2024

O interesse por epistolografia continua sendo decorrência de outro trabalho crítico. Mas, uma vez assim deflagrado, suscita outras indaga­ções, como por exemplo a respeito do estatuto da carta dentro dos estudos literários. No horizonte, entretanto, a vigência da carta parece estar ameaçada pelo advento da era eletrônica. São essas reflexões, que o pre­sente trabalho procura desenvolver.
Dossiers préparatoires et génese scénarique chez Zola
Authors: Leduc-Adine Jean-Pierre
Published: April 2024

0 que nos ensinam os dossiês preparatórios dos romances de Zola? Um de seus aspectos interessantes — mas longe de ser o único — é ver estabelecer-se; construir-se, uma estrutura narrativa que se apoia inicial­mente sobre modelos que são ao mesmo tempo modelos discursivos, mo­delos genéricos e modelos ideológicos. Desta maneira os primeiros planos de L’Assommoir prevêem um sistema que se estrutura em 21 capítulos, o número na versão definitiva será reduzido a 13• É primordial analisar ao mesmo tempo o como e o por quê dessa mudança. A cadeia de substitui­ções transforma-se em çadeia de transformações. O romance terminado esconde, sob seu aspecto acabado, os numerosos pontos de vista que são impostos ao romancista.
Poder de descobertas
Authors: Salles Cecília Almeida
Published: April 2024

Este artigo estará abordando os arquivos da criação como espaço de armazenamento de documentos de processo. Será enfatizado o aspecto indiciai desses documentos na medida em que são vestígios que apontam para o movimento do ato criador. Ao estabelecer o elo entre a indicialidade e a obtenção de conhecimento, estaremos dando especial atenção à neces­sidade de estabelecimento de relações entre os documentos e entre as in­formações neles preservadas. Nesta perspectiva os arquivos nos questio­nam em seu poder de ativar descobertas.
I colóquio do Núcleo de Apoio À Pesquisa em Crítica Genética — conceitos de criação
Authors: Salles Cecília Almeida
Published: April 2024

O objetivo deste artigo é fazer um relato dos resultados do I Colóquio do Núcleo de Apoio à Pesquisa em Crítica Genética (NAP- CG) que aconteceu no dia 29 de setembro de 2000, na PUC -SP. O NAP reúne pesquisadores de crítica genética da USP (Laboratório do Manuscrito Literário e do IEB) e da PUC/SP (Centro de Estudos de Critica Genética do Programa de Pós-Graduação em Comunicação e Semiótica).
Periodontal Treatment During the Blanking Period Improves the Outcome of Atrial Fibrillation Ablation
Authors: Miyauchi Shunsuke , Ouhara Kazuhisa , Shintani Tomoaki , Tokuyama Takehito , Okubo Yousaku , Okamura Sho , Miyamoto Shogo , Oguri Naoto , Uotani Yukimi , Takemura Tasuku , Tari Misako , Hiyama Toru , Miyauchi Mutsumi , Kajiya Mikihito , Mizuno Noriyoshi , Nakano Yukiko
Published: April 2024

Background

Periodontitis has not been recognized as a modifiable risk factor for atrial fibrillation (AF). This prospective nonrandomized study investigated whether periodontal treatment improves the AF ablation outcome.

Methods and Results

We prospectively enrolled 288 AF patients scheduled to undergo initial radiofrequency catheter ablation. Each patient underwent periodontal inflamed surface area (PISA; a quantitative index of periodontal inflammation) measurement. All eligible patients were recommended to receive periodontal treatment within the blanking period, and 97 consented. During the mean follow‐up period of 507±256 days, 70 (24%) AF recurrences were documented. Patients who exhibited AF recurrences had a higher PISA than those who did not (456.8±403.5 versus 277.7±259.0 mm
2
,
P
=0.001). These patients were categorized into high‐PISA (>615 mm
2
) and low‐PISA (<615 mm
2
) groups according to the receiver operating characteristic analysis for AF recurrence (area under the curve, 0.611; sensitivity, 39%; specificity, 89%). A high PISA, as well as female sex, AF duration, and left atrial volume, were the statistically significant predicter for AF recurrence (hazard ratio [HR], 2.308 [95% CI, 1.234–4.315];
P
=0.009). In patients with a high PISA, those who underwent periodontal treatment showed significantly fewer AF recurrences (
P
=0.01, log‐rank test). The adjusted HR of periodontal treatment for AF recurrence was 0.393 (95% CI, 0.215–0.719;
P
=0.002).

Conclusions

Periodontitis may serve as a modifiable risk factor for AF. PISA is a hallmark of AF recurrence, and periodontal treatment improves the AF ablation outcome, especially for those with poor periodontal condition.
Two new species of Achaeta (Enchytraeidae, Oligochaeta) from afforested post-mining and post-fire sites in Poland
Authors: SCHMELZ RÜDIGER M. , CHEN JUANJUAN , JÓZEFOWSKA AGNIESZKA
Published: April 2024

Achaeta (Enchytraeidae, Oligochaeta, Clitellata) is a genus of small, soil-dwelling annelids, peculiar by the absence of chaetae in all species. Here two new species of this genus are described from afforestation sites in southern Poland. Descriptions are based on the investigation of living and preserved material. The species are also characterized at the DNA level, using fragments of the COI and ITS genes, sequenced from the holotypes and paratypes. The worms are not longer than 4–6 mm, with about 30 to 35 segments, and with medium-large male and female reproductive organs. Achaeta florens sp. nov., discovered at a post-mining site, has four segmental pyriform glands, an oesophageal appendage restricted to segment V, a clitellum with distinct transverse rows and dorsal and ventral interruption, and spermathecae with blossom-like fields of vesicular gland cell apices around the ventrally located ectal pores. The species is without peculiar characters but the combination of characters is diagnostic. Its morphological distinction from A. nurmineni, described from the Indian subcontinent, is difficult due to the poor description of that species; A. nurmineni is therefore considered a species inquirenda. Achaeta gemmata sp. nov., discovered in high abundance at a post-fire site, is without pyriform glands but with conspicuous, gem-like lateral papillae in all preclitellar segments. The papillae are modified and enlarged epidermal gland cells that protrude into the body cavity. The species is without oesophageal appendage and has a dorsally closed clitellum and lateral spermathecal pores. It is superficially similar to Achaeta camerani, found at the same site, but can be distinguished based on sexual and non-sexual characters. A comparison of COI sequences showed 100% identity with a specimen from Sweden, erroneously identified as A. cf. brevivasa. Genetic distance between the two new species based on COI differences is 20%, distances to other species of Achaeta with publicly available COI sequences range from 16% to 26%.
Introduction
Authors: Makhloufi Lilia
Published: April 2024

The introduction to the book frames its study of the architectural and urban spaces that shape cities’ tangible heritage, considering the urban networks, residential spaces and materials and methods of construction. The book also examines the parameters governing societies’ intangible heritage by defining: (i) individuals according to local identities, cultures and religions, (ii) behaviours rooted in local ways of life and social values, and (iii) practices including local customs, feasts and festivals. It outlines the relevance of globalisation to the preservation of tangible and intangible heritage and introduces the different chapters and what they will contribute to the book.
7. Study on the Visual Perception of Historical Streetscapes Using Kansei Engineering
Authors: Kacha Lemya , Bouakar Mouenes Abd Elrrahmane
Published: April 2024

Lemya Kacha and Mouenes Abd Elrrahmane Bouakar investigate public spaces and their impact on the local community in the historic centre of Cherchell in Algeria, which has rich Punic, Roman, Arab-Andalusian, Ottoman and French heritage. The main objective of their analysis is to assess the perceptions and attractiveness of selected streetscapes among domestic tourists. Here, the Kansei Engineering method allowed them to quantify participants’ perceptions of streetscapes based on panoramic photographs. Through this method, which has significant potential in the field of sustainable cultural tourism and heritage conservation, the researchers found that the originality of the materials and the construction techniques are the main factors that have led to the preservation of heritage value. Moreover, the attractiveness of architectural heritage will contribute to enhancing both cultural and heritage tourism in the long term.
10. Integrity and Authenticity
Authors: Solari Irribarra Fabiola , Rojas Alfaro Guillermo
Published: April 2024

Fabiola Solari Irribarra and Guillermo Rojas Alfaro consider the vulnerability of urban and industrial constructions and their deterioration in arid climates. They question the authenticity of Humberstone and Santa Laura Salpeter Works in Chile according to the original fabrics and structures of this industrial heritage, the integrity of which has been harmed by the natural environment over time. In the last decade, several security measures and consolidation and stabilisation works were undertaken to conserve the tangible assets of this site. While conservation works partially compromised the original fabric and material aspects of the site, this change can be viewed as positive because the material decay of these mining complexes coexisted with efforts to keep them standing. In this way, these buildings and the choices made in conserving them bear witness to the key historical, industrial, and social processes associated with the heritage site.
Rally Around the Government or a Populist Response? How Concerns About COVID-19 and Emotional Responses Relate to Institutional Trust and Support for Right-Wing Populism
Authors: Lytkina Ekaterina , Reeskens Tim
Published: April 2024

Recent studies have shown that the coronavirus pandemic not only temporarily increased support for incumbent politicians and trust in experts but also triggered an authoritarian response. Because the pandemic has significantly affected individuals’ goals, needs, and control over their lives, we expect that it has generated emotional reactions. In this article, we study how concerns about COVID-19 relate to institutional trust (trust in political institutions and experts) and a preference for populist right parties—directly and indirectly—via emotions. Our theoretical framework relies on the “rally around the flag” hypothesis, the cultural backlash theory, as well as appraisal theories of emotions. We analyze a novel data set collected as part of the Longitudinal Internet Studies for the Social Sciences Panel Survey for the Netherlands at the beginning of the second wave of the pandemic (October 2020). Our findings reveal that concerns about COVID-19 are positively related to institutional trust but unrelated to preferences for right-wing populism. The relationship between concerns about the coronavirus crisis and trust in political institutions is mediated via fear and sadness; these emotions also explain opposition to right-wing populist parties. We interpret our findings in relation to research on the rally around the flag effect, right-wing populism, and emotions. We discuss the implications of our results in the context of the coronavirus pandemic and other “rally”-inducing events.
Optimized titanium dioxide loading for properties of natural rubber latex and acrylic emulsion blends
Authors: Worlee Anuwat , Hayeemasae Nabil , Masa Abdulhakim
Published: April 2024

Blends of prevulcanized natural rubber (PVNR) and acrylic emulsion (AC) were prepared at the fixed PVNR/AC ratio of 30/70. Effects of titanium dioxide (TiO2) addition were optimized across the contents 0, 10, 20 and 30 parts per hundred parts of polymer (php) with respect to various properties. Morphological analysis revealed a two-phase system in which the PVNR particles were dispersed in the AC matrix. Incorporation of TiO2 induced a finer blend morphology in which a part of the TiO2 was located at the interfaces of blend components. The tensile strength increased with initial TiO2 loading and reached its maximum at 10 php loading, with an improvement by about 127% over the blend without filler. However, further increase in filler loading reduced the tensile strength, and the filler tended to agglomerate at those higher loadings. Thermal stability and storage modulus in rubbery region of the blends containing TiO2 were also improved over the unfilled blend, due to the improved morphology and the hydrogen bonds between TiO2 filler and polymer matrix. TiO2 improved water wettability and adhesion of the blend. The maximum peel strengths on wood and metal substrates were about 120% and 26% larger than for the reference unfilled blend. Such drastic improvements suggest that the filled blends may find applications as coating materials.
Intergovernmental Transfers and Local Revenues Again—A Relook at the Ghanaian Local Government Case
Authors: Adanu Kwami
Published: April 2024

This paper revisits options for strengthening local governance by increasing own revenues in local government jurisdictions. Using stochastic frontier and recursive structural equation methods, the paper estimates the effects of central government transfers and tax effort on own revenues in the Ghanaian local government system. Results show that contrary to some recent findings that transfers reduce own revenues for local jurisdictions in Ghana, increasing transfers to local jurisdictions increases (rather than reduces) own revenues in Ghana. Further, local government performance in public service provision was found to be critical for increasing own revenues. Making the Ghanaian local government system more sustainable thus requires increasing central government transfers and providing technical support to strengthen the relationship between available public services and own revenues.
Mobility Energy Productivity Evaluation of On-Demand Transit: A Case Study in Arlington, Texas
Authors: Powell Bonnie , Acharya Sailesh , Zakaria Ruqayya , Grahn Rick , Henao Alejandro , Young Stanley E.
Published: April 2024

On-demand transit (ODT) systems are increasing in number and size. To evaluate and quantify outcomes, the research team utilizes the mobility energy productivity (MEP) metric, which is a holistic accessibility measure, to analyze and compare the mobility of various transportation modes in Arlington, Texas. The MEP tool is applied to the ODT system in Arlington, Texas, as well as to five existing transportation modes (driving, transportation network company, transit, biking, and walking). Six ODT scenarios are also analyzed and compared. The analysis is focused on the opportunities that an ODT system presents for transportation disadvantaged communities (DACs) with low rates of car ownership. Although driving received the highest MEP score—a finding typical for a U.S.A. city— the results for the ODT system reveal that it serves those in DACs effectively, helping to achieve an equity design goal. ODT improved the average MEP score across the service area by 83% when considering only accessible, nonprivate vehicle modes (biking, transit, and ODT). For the ODT scenarios, decreasing the wait time by 50% compared with the baseline scenario led to a nearly 160% increase in the MEP score, whereas increasing the ODT travel speed by 21% led to an 80% improvement in the MEP score. As analyzed through the MEP tool, this paper demonstrates how ODT can enhance mobility, particularly for DACs. The results of an MEP analysis can be used by researchers and transit agencies to compare transportation modes and improve the effectiveness of transportation systems across a service area.
Evaluating the WISE (Women in the South-East) Telehealth Network: A Model of Healthcare and Health Promotion at Rural Libraries
Authors: Sundstrom Beth , Hayes Natalia , DuBose-Morris Ragan , Dempsey Angela , Guille Constance , Montgomery Kathleen , Richardson Katherine , Lazenby Gweneth B.
Published: April 2024

Purpose

The purpose of this study was to evaluate the effectiveness of the WISE (Women in the South-East) Telehealth Network.

Design

A follow-up survey design was used to determine the impact of the program on access to healthcare.

Setting

WISE provided preventive care to women and gender expansive people at local libraries and the Mobile Library in the rural South Carolina Lowcountry.

Subjects

In 1 year (February 2021-2022), WISE reached 523 individuals with 151 agreeing to participate in the study. Most participants identified as white (66%) or Black (22%).

Intervention

A Community Health Worker provided health education, connection to telehealth services, referrals, and connected individuals with community and social services.

Measures

The Telehealth Usability Questionnaire (TUQ), changes in knowledge, satisfaction with WISE, Acceptability of Intervention measure (AIM), and sociodemographic characteristics.

Results

Participants with a high telehealth usability score were significantly more likely to be under the age of 35 (OR 4.60 [95% CI 1.21-17.52]), married (OR 10.00 [95% CI 2.19-45.64]), or white (OR 4.00 [95% CI 1.06-15.08]). The intervention earned a high acceptability score 4.46 (± .61)/5.0 by helping participants obtain necessary medical care and resources, as well as meeting their educational needs.

Conclusion

This study offers practical suggestions to expand the use of telehealth initiatives to improve health outcomes by engaging libraries in rural communities.
Maternal and fetal outcomes in pregnancy complicated by pre-existing lupus nephritis: Insights from a developing country Pakistan
Authors: Elahi Tabassum , Ahmed Saima , Mubarak Muhammed , Ahmed Ejaz
Published: April 2024

Background

Pregnancy in women with systemic lupus erythematosus (SLE) has remained a great challenge for clinicians in terms of maternal and fetal outcomes. The outcomes in women with pre-existing lupus nephritis (LN) are variable. The impact of different classes of LN on maternal and fetal outcomes during pregnancy is not well defined, as data is very scarce, especially from the developing countries.

Methods

A retrospective analysis was conducted on 52 women with 89 pregnancies. All had biopsy-proven LN. Those women who conceived at least 6 months after the diagnosis were included. The analysis was conducted between July 1998 and June 2018 at Sindh Institute of Urology and Transplantation (SIUT), evaluating the outcomes for both the mother and the fetus with a minimum follow-up of 12 months after child birth.

Results

The mean maternal age at SLE diagnosis was 21.45 ± 6 years and at first pregnancy was 26.49 ± 5.63 years. The mean disease duration was 14.02 ± 19.8 months. At conception, 47 (52.8%) women were hypertensive, 9 (10%) had active disease while 38 (42.7%) and 42 (47.2%) were in complete and partial remission, respectively. A total of 17 (19.1%) were on mycophenolate mofetil (MMF), which was switched to azathioprine (AZA). Out of 89 pregnancies, 56 (62.9%) were successful, while 33 (37.07%) had fetal complications like spontaneous abortion, stillbirth, perinatal death, and intrauterine growth retardation (IUGR). There were more vaginal deliveries (33 [58.92%]) than caesarean sections (23 [41.07%]). Renal flare was observed in 33 (37.1%) women while 15 (16.9%) developed pre-eclampsia. Proliferative LN was found in 56 (62.9%) cases, but no significant differences were found in maternal and fetal outcomes in relation to LN classes ( p = .58). However, disease outcomes at 12 months were significantly poor in those with active disease at the time of conception ( p < .05). There was only one maternal death. A total of 10 (11.2%) women showed deterioration in renal function and 5 (5.6%) were dialysis-dependent at 12 months.

Conclusion

The maternal and fetal outcomes in pre-existing LN depend on the disease activity at the time of conception. No correlation was found between International Society of Nephrology/Renal Pathology Society (ISN/RPS) classes of LN and adverse disease and pregnancy outcomes.
Ecosystem Orchestration: Unpacking the Leadership Capabilities of Anchor Organizations in Nascent Entrepreneurial Ecosystems
Authors: Harima Aki , Harima Jan , Freiling Jörg
Published: April 2024

Although prior research emphasizes the essential role of anchor organizations’ leadership in entrepreneurial ecosystem development in the early stages, their strategic functions are undertheorized. This study conducted a single case study with the entrepreneurial ecosystem of Santiago de Chile as a revelatory case by examining how anchor organizations catalyze the early evolution of the entrepreneurial ecosystem from the perspective of the orchestration theory. We developed a framework of ecosystem orchestration to demonstrate how anchor organizations adapt their strategic functions in managing and building various networks and resources to dynamic environments in entrepreneurial ecosystems.