bluuebunny/crossref_metadata_2025 huggingface dataset:
Factors that Influence the Hostels’ Activity in Odintsovo
Authors: Kulakova Aleksandra Vitalevna , Ugurchieva Izabella Magometovna
Published: February 2021

In currently dynamic environment and fierce competition, hostels are forced to focus not only on the internal state of affairs of the company, but also on developing a long-term strategy of behavior that would allow them to quickly respond to changes in their environment. To analyze the micro-level of the organization's external environment, a competitive analysis is used according to the Porter's five forces model (the intensity of competition among existing players, the threat of the appearance of substitute goods, the threat of new players on the market, the bargaining power of suppliers and the bargaining power of consumers). The article analyzes the Porter's model and assesses the factors that influence hostels’ activities in Odintsovo.
MODELAGEM BIM PARA REGISTRO DIGITAL DO PATRIMÔNIO ARQUITETÔNICO MODERNO
Authors: Aparecida Costa Heliara , SOUZA MARCIO PRESENTE DE , QUINILATO BALDESSIN GUILHERME , ALBANO GABRIELA , MINTO FABRÍCIO MARCIO
Published: February 2021

A metodologia Building Information Modelling (BIM) é, atualmente, uma das principais expressões das inovações tecnológicas digitais aplicadas à Arquitetura, Engenharia, Construção e Operação. Trata-se de instrumento capaz de analisar grande quantidade de informações, por meio de um modelo virtual que gerencia o ciclo de vida do edifício, voltado as fases anteriores à construção. Para edifícios construídos tem-se o conceito de HBIM (Historic Building Information Modelling) como alternativa de gerenciamento, na qual objetos paramétricos são construídos a partir de dados de edifícios históricos. No entanto, componentes destinados ao registro histórico são raros em bibliotecas BIM e exigem grande esforço de modelagem, necessitando de protocolos e especificações relativos aos seus processos. Este artigo identifica e analisa meios para modelagem de componentes de um edifício histórico em BIM, partindo de um elemento do edifício moderno E1, localizado no campus USP São Carlos, SP. O método consistiu em revisão bibliográfica, levantamentos no local, modelagem paramétrica e avaliação das formas de desenvolvimento dos componentes, com uso de software BIM. Os resultados identificam três processos distintos de modelagem: Família de Sistema, Família Composta e Família Modelada no Local. A contribuição do artigo é a descrição e discussão dos procedimentos adotados, das potencialidades e limitações de cada processo e da sua aplicação a estudos similares. Os elementos produzidos foram disponibilizados em um repositório público, a fim de possibilitar seu registro, documentação e uso em projetos de gestão, manutenção, preservação e reconstrução do patrimônio estudado, e também como modelo exemplificado para bibliotecas HBIM a serem futuramente construídas.
PROPOSTA DE MERCADO PÚBLICO ATRAVÉS DOS CONCEITOS DA PERMACULTURA URBANA
Authors: Santos Ísis Portolan dos , Quoos Mayer Licia
Published: February 2021

O presente trabalho trata de uma pesquisa e de um projeto arquitetônico/paisagístico realizados para o Trabalho Final de Graduação do Curso de Arquitetura e Urbanismo da Universidade Federal de Santa Maria (UFSM/RS). A metodologia do projeto iniciou com a pesquisa e posterior seleção de diretrizes, zoneamentos, estudos de fluxos e de volumetria até a proposição arquitetônica e paisagística na forma de um anteprojeto. A pesquisa contemplou o levantamento histórico, físico, cultural e social do terreno e dos prováveis usuários. A revisão bibliográfica analisou o histórico dos mercados públicos, a permacultura, o paisagismo produtivo e as soluções sustentáveis na construção civil. O levantamento de dados ocorreu através da aplicação de questionário para usuários e comerciantes locais, e também da seleção e análise dos aspectos físico-sociais da cidade, do bairro e do entorno próximo ao sítio elegido.  Estes serviram para a elaboração do programa de necessidades, vinculados com as premissas indicadas no referencial teórico. A partir de então, foram inseridos itens da permacultura em diferentes aspectos do projeto, tais como a: recuperação de áreas de preservação, paisagismo produtivo urbano, utilização de estruturas e materiais naturais, apresentação de infraestruturas alternativas como solução para saneamento básico, tratamentos dos efluentes nos espaços urbanos e destinação adequada de resíduos sólidos. Assim, foi possível desenvolver uma proposta arquitetônica e paisagística com premissas da permacultura que se apresentam como soluções pertinentes para espaços públicos, em específico para um Mercado Público em um bairro de Santa Maria/RS.
Aptamer Based Diagnosis: A Cost-Effective and Suitable Point of Care Testing Method Against SARS Coronavirus-2 (SARs-CoV-2) and Other Rapidly Spreading Diseases
Authors: Kumar Vivek , Yadav Gulab S. , Banerjee Basu D.
Published: February 2021

The current SARS coronavirus-2 (SARS-CoV-2) pandemic has raised serious concerns
regarding the inefficiency of available diagnostic methods for rapid and efficient detection of the
disease. It is agreed widely that Real-time Polymerase Chain Reaction (RT-PCR) and antibody-
based assays have several limitations that did not help much in preventing the exponential
spread of the disease in a short span of period. Unarguably, the world needs “new-generation diagnostic
intervention(s)” against rapidly spreading disease like SARS-CoV-2. We have presented an
aptamer-based strategy as a possible point of care testing for the diagnosis of the disease. It has several
advantages over current tools available and can be used for efficient combating by the mean of
quick,cost-effective and much more accurate diagnostic against the enigmatic SARS-CoV-2 disease
and similar pandemic which world may possibly encounter in the future.
Antimicrobial Resistance: The Potent Enemy Lurking Behind COVID-19
Authors: Kanwar Rohini , Kumar Amit , Rathee Jyoti , Mehta Surinder K.
Published: February 2021

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has emerged as a global
pandemic due to its high transmissibility and pathogenicity. It is a beta clade zoonotic coronavirus
like severe acute respiratory syndrome coronavirus (SARS-CoV) and middle east respiratory
syndrome coronavirus (MERS-CoV). Though no effective medication has been developed
against the deadly COVID-19 disease, henceforth old antimicrobial drugs have been repurposed to
treat the COVID-19 patients. In this report, a brief account of the used medication and the potential
mechanism of antimicrobial drugs against SARS-CoV-2 has been provided. Based on the earlier incidences,
the antimicrobials are expected to lose the battle against SARS-CoV-2. The vast lacuna
in the research and development of vaccines has led to overuse of the already formulated antimicrobial
drugs, which in turn has led to a distressing problem called “Antimicrobial resistance (AMR)”.
A complete assay of AMR has been given including its cause, mechanism, spread, and consequences.
The other two interlinked problems, namely environmental deterioration and secondary infections,
are elaborated. Moreover, to combat the AMR problem, the way forward has been discussed
in detail.
An Update of Armamentarium for Non Invasive Cardiac Haemodynamics and Congestion Evaluation for Acute Heart Failure Patients
Authors: Di Somma Salvatore
Published: February 2021

In the management of Acute Heart Failure(AHF) patients ,current guidelines suggest to make a prompt clinical assessments that include patient’s congestion and perfusion status evaluation, in order to start appropriate treatments. Unfortunately ,so far, an accurate evaluation of haemodynamic and fluid status of AHF patients is only possible using invasive methods ;conseguently there is an unmeet need for noninvasive technologies to easly detect different phenotypes of AHF subjects based on different cardiac haemodynamic profiles . Technological advances such as: Biva,Nexfin or NICas could allow for routine noninvasive continuous monitoring of Cardiac Hemodymanics and Fluid content in Acute Heart Failure patients. These non invasive measurements may provide important information for improving diagnosis, developing individualized therapeutic management plans/disposition decisions and predicting short term mortality
The Role of Garcinia Mangostana Pericarp Extract as Antioxidant to Inhibit Atherosclerosis Process in High Risk Framingham Score Patient; Original Article
Authors: Munandar Zulkifli Ismail Aris , Sargowo Djanggan , Tri Tjahjono Cholid , Widito Sasmojo , Rizal Ardian
Published: February 2021

Atherosclerosis is the pivotal role of cardiovascular disease (CVD) involving oxidative stress dan inflammation. Garcinia has anti-oxidant property for years. This study was performed to explore the role of α-Mangostin of Garcia Mangostana Pericarp Extract as an antioxidant in inhibiting atherosclerotic process in patients with high-risk Framingham score. Methods: This prospective cohort design was led in 90 grown-ups with high hazard cardiovascular score which were resolved dependent on Framingham criteria, age 50–70 years of age. The patients were divided into two groups. One group was administered 2520 mg/day Garcinia mangostana Linn extracts (GMLE) in 3 divided doses for 90 days and the other group was administered a placebo. Parameters were Nitric Oxide (NO), Superoxide Dismutase (SOD) and Malondialdehyde (MDA), measured at baseline and after 90 days of treatment. An Independent T-test was performed for normally distributed data and the Mann-Whitney test was performed for abnormally distributed data with a significance level of p≤0.05. Results: Among the 77 subjects, we found that the plasma, MDA, concentration was significantly decreased compared with placebo 0,29±0.5 vs -0.04±0.25, respectively p = 0.011). SOD level significantly decreased in GMLE patients compared with placebo patients (0,17±0.79 vs -0.27±0.67, respectively, p=0.010) and we found that there was slightly increased in nitric oxide (NO), but no significantly compared with placebo 4.34±10.01 and 2.35±7.39, respectively, p = 0.37). Conclusion: Garcinia mangostana pericarp extract has an antioxidant effect that significantly inhibit atherosclerosis process in high-risk Framingham score patients
Role of LAVi/A’ and E/’ as A Predictor of Major Adverse Cardiac Event on Patient with Acute Myocardial Infraction with ST Segment Elevation Undergo Through Percutaneous Coronary Intervention
Authors: Reza Pratama Aditya , Satrijo Budi , Fuji Rahimah Anna , Sargowo Djanggan , Tri Tjahjono Cholid , Rizki Fadlan Muhammad
Published: February 2021

ntroduction: STEMI is still a major health problem in industrialized and developing countries. The risk of adverse cardiovascular events remains substansial and may vary significantly across of STEMI patients. Echocardiography is recommended tool for diagnosis and predict outcomes. Increased LA volume index (LAVI) has been shown to be a powerfull predictor of mortality after AMI. The ratio of the left atrial volume index (LAVI) and late diastolic mitral annular velocity (A’) is additional benefits in the assessment od advance diastolic dysfunction in ACS for predicting outcome. Methods: This study retrospective cohort was conducted in patient admitted to Saiful Anawar General Hospital with STEMI who undergo PCI from 2019-2020. All patient underwent echocardiography measurement within 24-48 hours and we follow-up patient for 6 months until 12 months. Echocardiography measurement that we conducted were LVEF, E/A, E/e’, LAVI/A’ and LV diastolic function were measured according to ASE guidelines. All of the patients were given standard medical therapy. Patients who did not adhere to medication were excluded. The study endpoints were hospitalisation and mortality because of cardiac problem. Result: We collected the data from 169 STEMI patients. However, about 39 STEMI patients were excluded because of incomplete data, lost follow-up, become atrial fibrillation, refused participation and death. Finally, a total of 130 patients were involved in the analysis process. The patients mean age was 61.48 ± 7 years, and 78% of them were male. The receiver operating characteristics curve indicated that LAVI/A’ ≥ 4.0 predicted these events (AUC 0.892, 95% CI 0.819-0.965) and E/e’ ≥ was 13.4 (AUC 0.874, 95% CI; 0.806-0.942). The MACE incident in 6 months with LAVI/A’ ≥ 4.0 was 40%, E/e’ ≥ 13.4 was 20% and LAVI/A’ ≥ 4.0 + E/e’ ≥ 13.4 was higher 60%. The incidence MACE incident was LAVI/A’ > 4.0 sensitivity 92% and specifity 88% (CI 95%), E/e’ > 13.4 sensitivity 80% and specifity 74% (CI 95%), LAVI/A’ > 4.0 + E/e’ > 13.4 sensitivity 92% and specifity 88% (CI 95%). Conlussion: The LAVI/A’ ratio is available as echo index which reflects LV chronic diastolic function in patient with STEMI. It can predict MACE, particularly in those with STEMI undergo PCI. Combined LAVI/A’ > 4.0 and E/e’ >13,4 ratio suggests MACE better than LAVI/A’ > 4.0 and E/e’ >13,4 alone. Keywords: ST-elevation Myocardial Infarction, Echocardiography, LAVI/A’, E/e’, Percutaneous Coronary Intervention
The Added Value of Bioimpedance Analysis to NT-proBNP in Predicting Short-term outcome in Acute Heart Failure Patients
Authors: Annisa Kamila Putri , Saifur Rohman Mohammad , Anjarwani Setyasih , Sargowo Djanggan , Fuji Rahimah Anna , Prasetya Indra , Rizki Fadlan Muhammad , Di Somma Salvatore
Published: February 2021

Background: Acute heart failure (AHF) is a significant clinical problem, which has a high prevalence, mortality, and rehospitalization. Congestion is critical in AHF's pathogenesis, which is also a predictor of mortality and rehospitalization in patients with AHF. Aim: Knowing the effect of adding a %Total body water (TBW) test detected by Bioimpedance Analysis to NT-proBNP as a short-term clinical outside predictor of patients with acute heart failure Method: This research is an analytical observational study using prospective cohort methods. The research was conducted at Dr. Saiful Anwar Malang Hospital in January 2018-July 2019, with research subjects taken consecutively against all AHF patients hospitalized at UD dr.UD dr. Saiful Anwar Malang. The data taken in the form of NT-proBNP value during mission and %TBW before the patient leaves the hospital detected with NICaS examination, then the outside seen is mortality rate and rehospitalization due to AHF within 90 days after exiting the hospital. Results: This study involved 65 subjects who were 61 years old and the majority male. Non-survivor patients had a higher NYHA class, NT-proBNP, and %TBW predischarge than the survivor group. Based on statistical analysis, we found that NT-proBNP is a good predictor of mortality (HI: AUC 0.74; 95%CI 0.59-0.90) and rehospitalization (HI: AUC 0.88; 95%CI 0.78-0.97). Similarly , %TBW pre-discharge shows good predictors of mortality (HI: AUC 0.72, 95%CI 0.56-0.87) and rehospitalization (HI: AUC 0.83, 95%CI 0.73-0.94). The addition of the %TBW predischarge parameter to NT-proBNP results in the best predictor numbers among the three for both mortality (HI: AUC 0.84; 95%CI 0.72-0.96) and rehospitalization (HI: AUC 0.92; 95%CI 0.85-1.00). Conclusion: The addition of predischarge %TBW examination detected by bioimpedance analysis tool against NT-proBNP increases the predicted value of short-term clinical outpatient in the form of mortality and rehospitalization of acute heart failure patients.
Implementation of the Living Well During Pregnancy Telecoaching Program for Women at High Risk of Excessive Gestational Weight Gain: Protocol for an Effectiveness-Implementation Hybrid Study
Authors: de Jersey Susan , Meloncelli Nina , Guthrie Taylor , Powlesland Hilary , Callaway Leonie , Chang Angela T , Wilkinson Shelley , Comans Tracy , Eakin Elizabeth
Published: February 2021

Background

Despite comprehensive guidelines for healthy gestational weight gain (GWG) and evidence for the efficacy of dietary counseling coupled with weight monitoring on reducing excessive GWG, reporting on the effectiveness of interventions translated into routine antenatal care is limited.

Objective

This study aims to implement and evaluate the Living Well during Pregnancy (LWdP) program in a large Australian antenatal care setting. Specifically, the LWdP program will be incorporated into usual care and delivered to a population of pregnant women at risk of excessive GWG through a dietitian-delivered telephone coaching service.

Methods

Metrics from the RE-AIM (Reach, Effectiveness, Adoption, Implementation, and Maintenance) framework will guide the evaluation in this hybrid effectiveness-implementation study. All women aged ≥16 years without pre-exiting diabetes with a prepregnancy BMI >25 kg/m2 and gaining weight above recommendations at <20 weeks’ gestation who are referred for dietetic care during the 12-month study period will be eligible for participation. The setting is a metropolitan hospital at which approximately 6% of the national births in Australia take place each year. Eligible participants will receive up to 10 telecoaching calls during their pregnancy. Primary outcomes will be service level indicators of reach, adoption, and implementation that will be compared with a retrospective control group, and secondary effectiveness outcomes will be participant-reported anthropometric and behavioral outcomes; all outcomes will be assessed pre- and postprogram completion. Additional secondary outcomes relate to the costs associated with program implementation and pregnancy outcomes gathered through routine clinical service data.

Results

Data collection of all variables was completed in December 2020, with results expected to be published by the end of 2021.

Conclusions

This study will evaluate the implementation of an evidence-based intervention into routine health service delivery and will provide the practice-based evidence needed to inform decisions about its incorporation into routine antenatal care.

International Registered Report Identifier (IRRID)

DERR1-10.2196/27196
The Reliability of Remote Patient-Reported Outcome Measures via Mobile Apps to Replace Outpatient Visits After Rotator Cuff Repair Surgery: Repetitive Test-Retest Comparison Study for 1-Year Follow-up (Preprint)
Authors: Hong Taek Ho , Kim Myung Ku , Ryu Dong Jin , Park Jun Sung , Bae Gi Cheol , Jeon Yoon Sang
Published: March 2021

BACKGROUND

With the development of health care–related mobile apps, attempts have been made to implement remote patient-reported outcome measures (PROMs). In order for remote PROMs to be widely used by mobile apps, the results should not be different depending on the location; that is, remote PROM results performed in locations other than hospitals should be able to obtain reliable results equivalent to those performed in hospitals, and this is very important. However, to our knowledge, there are no studies that have assessed the reliability of PROMs using mobile apps according to the location by comparing the results performed remotely from the hospital and performed at the outpatient visits.

OBJECTIVE

The purpose of this study was to evaluate the reliability of remote PROMs using mobile apps compared to PROMs performed during outpatient follow-up visits after arthroscopic shoulder surgery.

METHODS

A total of 174 patients who underwent arthroscopic rotator cuff repair completed questionnaires 2 days before visiting the clinic for the 1-, 2-, 3-, 6-, and 12-month follow-ups (test A). The patients completed the questionnaires at the clinic (test B) using the same mobile app and device for the 1-, 2-, 3-, 6-, and 12-month follow-ups. Test-retest comparisons were performed to analyze the differences and reliability of the PROMs according to the period.

RESULTS

Comparisons of tests A and B showed statistically significant differences at 1, 2, and 3 months (all Ps<.05 except for the ASES function scale at 3-months) but not 6 or 12 months after surgery (all Ps>.05). The intraclass correlation values between the two groups were relatively low at the 1-, 2-, and 3-month follow-ups but were within the reliable range at 6 and 12 months after surgery. The rate of completion of tests A and B using the mobile app was significantly lower in the group older than 70 years than in the other groups for all postoperative periods (P<.001).

CONCLUSIONS

PROMs using mobile apps with different locations differed soon after surgery but were reliably similar after 6 months. The remote PROMs using mobile apps could be used reliably for the patient more than 6 months after surgery. However, it is to be expected that the use of mobile app–based questionnaires is not as useful in the group older than 70 years as in other age groups.
Understanding the Research Landscape of Deep Learning in Biomedical Science: Scientometric Analysis (Preprint)
Authors: Nam Seojin , Kim Donghun , Jung Woojin , Zhu Yongjun
Published: February 2021

BACKGROUND

Advances in biomedical research using deep learning techniques have generated a large volume of related literature. However, there is a lack of scientometric studies that provide a bird’s-eye view of them. This absence has led to a partial and fragmented understanding of the field and its progress.

OBJECTIVE

This study aimed to gain a quantitative and qualitative understanding of the scientific domain by analyzing diverse bibliographic entities that represent the research landscape from multiple perspectives and levels of granularity.

METHODS

We searched and retrieved 978 deep learning studies in biomedicine from the PubMed database. A scientometric analysis was performed by analyzing the metadata, content of influential works, and cited references.

RESULTS

In the process, we identified the current leading fields, major research topics and techniques, knowledge diffusion, and research collaboration. There was a predominant focus on applying deep learning, especially convolutional neural networks, to radiology and medical imaging, whereas a few studies focused on protein or genome analysis. Radiology and medical imaging also appeared to be the most significant knowledge sources and an important field in knowledge diffusion, followed by computer science and electrical engineering. A coauthorship analysis revealed various collaborations among engineering-oriented and biomedicine-oriented clusters of disciplines.

CONCLUSIONS

This study investigated the landscape of deep learning research in biomedicine and confirmed its interdisciplinary nature. Although it has been successful, we believe that there is a need for diverse applications in certain areas to further boost the contributions of deep learning in addressing biomedical research problems. We expect the results of this study to help researchers and communities better align their present and future work.
The Effects of Mobile Technology Based Support on Depressed Young Women: A Mixed-methods Study (Preprint)
Authors: Jeong Sookyung , Nam Sujin , Cha Chiyoung , Song Jiyoon
Published: February 2021

BACKGROUND

The current body of knowledge has highlighted the potential role of mobile technology as a medium to deliver support for psychological and physical health.

OBJECTIVE

The purpose of this study was to evaluate the influence of support provided using mobile technology on depressive symptoms and physical activity among female university students.

METHODS

A mixed-methods sequential explanatory design was used to conduct a single-site, randomized controlled quantitative study followed by a qualitative study. A total of 99 participants were block randomized based on the severity of their depressive symptoms into three arms: an emotional and informational support group, an informational support group, and a control group. Interventions were delivered for two weeks. Data from 84 participants on the depressive symptoms and physical activity were collected at baseline, day 8, and day 15. Individual interviews of 24 participants from the three arms were conducted. Data analysis included descriptive statistics, t-tests, one-way ANOVA and RMANOVA for quantitative data and content analysis for qualitative data.

RESULTS

Although significant difference was not reported in depressive symptoms over time among three groups, depressive symptoms decreased significantly at each of the time during the intervention (F=27.83, P<.001). The differences in the change in physical activity were significant among three groups over the intervention period (F=4.72, P=.01) and the degree of change differed significantly (F=2.53, P=.004). From post hoc analysis, the emotional and informational support group had a greater reduction in depressive symptoms than the control group, and a greater increase in physical activity than the control group. Analysis of interview revealed that making anonymous connections facilitated emotional stability, informational support was an instant stimulus for physical activity, continuous emotional support was the key to maintaining physical activity, and increased physical activity alleviates depressive symptoms.

CONCLUSIONS

Mobile technology could be used as a medium for support for depressive symptoms and physical activity in the short term. Emotional support might be a key to maintaining physical activity.
Digital Community Inclusion of Individuals With Serious Mental Illness: A National Survey to Map Digital Technology Use and Community Participation Patterns in the Digital Era (Preprint)
Authors: Shpigelman Carmit Noa , Tal Amir , Zisman-Ilani Yaara
Published: February 2021

BACKGROUND

Despite the growing interest in developing and using mobile health (mHealth) and digital technologies in mental health, little is known about the scope and nature of virtual community inclusion.

OBJECTIVE

The overarching goal of this study was to understand and conceptualize virtual community inclusion of individuals with serious mental illness (SMI). Specific objectives of this study were as follows: (1) mapping the prevalence, trends, and experiences related to mHealth and digital technology use among individuals with SMI; (2) comparing patterns of technology use by individuals with and those without SMI; and (3) examining whether use of mHealth and digital technologies predicts recovery among individuals with SMI.

METHODS

A web-based survey of technology use and virtual participation was developed and distributed among adults with and those without SMI via social media, national email discussion lists, nonprofit organizations, and advocacy groups.

RESULTS

A total of 381 adults aged 18 years or older participated in the survey, of whom 199 (52%) identified as having a SMI. Participants with SMI reported significantly greater access to technology and significantly fewer days of face-to-face participation in community activities than those without SMI. Among participants with SMI, greater technology use was positively associated with positive emotions and significantly predicted recovery.

CONCLUSIONS

This study is the first to explore, map, and conceptualize virtual community inclusion among adults with SMI. Our findings indicate a gap in the literature and research on community inclusion and participation, and emphasize the need for virtual community inclusion, particularly during the COVID-19 pandemic and its future implications.
Usability and perceived usefulness of patient-centered medication reconciliation using a personalized health record (Preprint)
Authors: van der Nat Denise Jacoline , Huiskes Victor J B , Taks Margot , Pouls Bart , van den Bemt Bart J F , van Onzenoort Hein A W
Published: March 2021

BACKGROUND

The acceptance and usage of a personalized health record (PHR) depends on usability and perceived usefulness of the PHR.

OBJECTIVE

Therefore, the aim of this study was to assess usability and perceived usefulness of an online PHR for medication reconciliation and to describe associations between usability and perceived usefulness and patient-, setting-, and medication-related factors.

METHODS

A multicenter cross-sectional study was conducted with patients with either an outpatient visit (rheumatology ward) or planned admission in the hospital (cardiology, neurology, internal medicine or pulmonary wards). All patients received an invitation to update their medication list in an online PHR two weeks prior to their appointment/admission. One month after the hospital visit, PHR-users were asked to rate usability (using the System Usability Scale (SUS)) and perceived usefulness on a 5-point Likert scale. The SUS-scores were classified according to the adjective rating scale and furthermore dichotomized in the categories: low (SUS between 0-51) or good (SUS 51-100) usability. Association between patient-, setting-, and medication-related factors and the usability and perceived usefulness were analysed.

RESULTS

255 (34%) of the 743 invited PHR-users completed the questionnaire. The majority of inpatients (78%) and outpatients (83%) indicated that usability of the PHR was good. At the outpatient clinic, experience with digital devices (adjusted odds ratio 1.36; 95%CI:1.01–1.83) was significantly associated with a good usability. Regarding perceived usefulness, the majority of the in- and outpatients (76% and 78%, respectively) reported that the PHR yielded at least one benefit (out of seven) with regard to their visit to the physician.

CONCLUSIONS

Usability and perceived usefulness of a PHR for medication reconciliation were rated by patients as good. Further research should explore the barriers and facilitators of patients with a low rated usability and perceived usefulness.
Predicting Patient Deterioration: A Review of Tools in the Digital Hospital Setting (Preprint)
Authors: Mann Kay D , Good Norm M , Fatehi Farhad , Khanna Sankalp , Campbell Victoria , Conway Roger , Sullivan Clair , Staib Andrew , Joyce Christopher , Cook David
Published: March 2021

BACKGROUND

Early warning tools identify patients at risk of deterioration in hospitals. Electronic medical records in hospitals offer real-time data and the opportunity to automate early warning tools and provide real-time, dynamic risk estimates.

OBJECTIVE

This review describes published studies on the development, validation, and implementation of tools for predicting patient deterioration in general wards in hospitals.

METHODS

An electronic database search of peer reviewed journal papers from 2008-2020 identified studies reporting the use of tools and algorithms for predicting patient deterioration, defined by unplanned transfer to the intensive care unit, cardiac arrest, or death. Studies conducted solely in intensive care units, emergency departments, or single diagnosis patient groups were excluded.

RESULTS

A total of 46 publications were eligible for inclusion. These publications were heterogeneous in design, setting, and outcome measures. Most studies were retrospective studies using cohort data to develop, validate, or statistically evaluate prediction tools. The tools consisted of early warning, screening, or scoring systems based on physiologic data, as well as more complex algorithms developed to better represent real-time data, deal with complexities of longitudinal data, and warn of deterioration risk earlier. Only a few studies detailed the results of the implementation of deterioration warning tools.

CONCLUSIONS

Despite relative progress in the development of algorithms to predict patient deterioration, the literature has not shown that the deployment or implementation of such algorithms is reproducibly associated with improvements in patient outcomes. Further work is needed to realize the potential of automated predictions and update dynamic risk estimates as part of an operational early warning system for inpatient deterioration.
Status gizi dan gambaran klinis penyakit pada pasien HIV anak awal terdiagnosis
Authors: Indrawanti Ratni , Arguni Egi , Laksanawati Ida Safitri , Puspitasari Dwiyanti , Husada Dominicus
Published: February 2021

Nutritional status and clinical disease of HIV children patients when diagnosed for the first timeBackground: Human immunodeficiency virus (HIV) infection in children can cause nutritional problems. Currently, HIV-infected children are still diagnosed when the disease stage is advanced. Nutritional status is a marker of advanced stage conditions in HIV infection.Objective: To determine the clinical findings of disease and nutritional status of HIV children patients when diagnosed for the first time.Methods: We conducted a cross-sectional descriptive study. The data were taken from the medical record documents of child patients aged 0-18 years with the ICD 10 code B20, who was treated at the Dr. Sardjito Yogyakarta Hospital from 1 January 2004-31 December 2019. Results: There were 191 children diagnosed with HIV, 56% of them were boys. The median age was 34 months (IQR 25: 13 months, IQR 75: 69 months), and 95.5% among those were infected perinatally. There were 77 (40,3%) children who suffered from severe malnutrition and 55 (28.8%) children were moderate acute malnutrition. At the age of 0-60 months among them, there were 49 children (36.3%) suffered from severely underweight, 35 children (25.9%) underweight, 53 (39.3%) severely stunted, 38 (28.1%) stunted, 28 severely wasted (20.7%), and wasted as many as 24 (17.8%). At the age of 5-18 years old, there were 19 (33.9%) and 5 (8.9%) children who suffered from severely wasted and wasted respectively. World Health Organization (WHO) stages 3 and 4 were experienced by 62 (32.5%) and 68 (35.6%) children. As many as 41.3% of children had enlarged lymph nodes, thrush (40.8%), pneumonia (40.8%), and persistent or chronic diarrhea (21.5%). Conclusions: The nutritional status of HIV-infected children at baseline was dominated by underweight and stunted. The most clinical findings of the disease when the child was diagnosed with HIV infection were lymphadenopathy, oral thrush, pneumonia, and persistent or chronic diarrhea.
The U.S. Alkaline AA Battery Market: A Competitive Profile
Authors: Datta Y.
Published: February 2021

This paper follows the footsteps of eleven studies that have tried to analyze the competitive profile of U.S. consumer markets: Men’s Shaving Gel, Beer, Shampoo, Shredded/Grated Cheese, Refrigerated Orange Juice, Men’s Razor-Blades, Women’s Razor-Blades, Toothpaste, Canned Soup, Coffee, and Potato Chips.Porter associates high market share with cost leadership strategy which is based on the idea of competing on a price that is lower than that of the competition. However, customer-perceived quality—not low cost—should be the underpinning of competitive strategy, because it is far more vital to long-term competitive position and profitability than any other factor. So, a superior alternative is to offer better quality vs. the competition.In most consumer markets a business seeking market share leadership should try to serve the middle class by competing in the mid-price segment; and offering quality better than that of the competition: at a price somewhat higher to signify an image of quality, and to ensure that the strategy is both profitable and sustainable in the long run. Quality, however, is a complex concept consumers generally find difficult to understand. So, they often use relative price, and a brand’s reputation, as a symbol of quality.For 2008 we chose the Alkaline AA Battery because its sales were $667 million vs. $283 million for AAA. By the same token, we have focused our analysis on AA 4-pack because it was the most popular size with 2008 sales of $190 million.In 2008 the AA 4-pack Alkaline Battery market was quite competitive with 30 brands with sales over $25,000.Using Hierarchical Cluster Analysis, we tested two hypotheses: (1) That the market leader is likely to compete in the mid-price segment, and that (2) Its unit price is likely to be higher than that of the nearest competition.For 2008 the results supported Hypothesis I and II. Both the market leader Energizer, and the runner-up Duracell, were members of the mid-price segment. Moreover, the unit price of Energizer was higher than that for Duracell, as we have hypothesized.For 2007 the results did not support Hypothesis I, because Energizer found it to be a member of the premium segment, even though Duracell maintained its association with the mid-price segment. We found that relative price was a strategic variable, as hypothesized.We also discovered four strategic groups in the industry.
UKLjUČIVANJE MARGINALIZOVANIH GRUPA U LOKALNU ZAJEDNICU
Authors: Martinovic Slobodan
Published: February 2021

Veću uključenost marginalizovanih grupa u lokalnu zajednicu može da omogući dobro organizovana mreža podrške svih aktera koji su u okviru svoje delatnosti obavezni obezbediti uslove za ostvarenje ljudskih prava na principima dostupnosti, participacije i jednakosti. Da bi se moglo raditi na poboljšanju postojeće prakse, potrebno je definisati probleme u ostvarivanju prava marginalizovanih grupa u lokalnoj zajednici i napraviti presek sadašnjeg stanja u cilju dubljeg sagledavanja potreba marginalizovanih grupa u lokalnoj zajednici. Dobijeni rezultati treba da obezbede: identifikovanje potreba marginalizovanih grupa u lokalnoj zajednici i moguća rešenja za potrebe marginalizovanih grupa u lokalnoj zajednici
EVALUACIJA POSTOJEĆIH MERA I USLUGA NAMENJENIH PORODICAMA DECE SA SMETNJAMA U RAZVOJU
Authors: Kovacevic Ankica Simona
Published: February 2021

Porodica dece sa smetnjama u razvoju ima ključnu ulogu u zadovoljavanju životnih potreba deteta i glavni su agens njihove inkluzije u društvo. Kako bi nesmetano obavljala ove funkcije, očuvala kvalitet života i sprečila nastajanje socijalne isključenosti, porodici je neophodna društvena podrška. Cilj ovog rada jeste da kroz analizu sadržaja relevantne zakonske regulative i raspoložive literature da uvid u nivoe i oblike koji se obezbeđuju ovim porodicama kroz pružanje formalne podrške. Analiza se odnosila na specifičnosti usluga socijalne zaštite i materijalnu podršku koje su predstavljene u tri koraka: praktični, finansijski i emocionalni. Rezultati analize ukazuju da porodica nije u dovoljnoj meri osnažena i tretirana kao potencijal koji čini temelj u uspostavljanju inkluzivnih vrednosti i društva. Podsticaj za pronalaženje kapaciteta i mehanizama da porodica bude produktivan faktor ogleda se u uspostavljanju organizovane, standardizovane, sistemske i blagovremene institucionalne podrške.
SPICE-МОДЕЛИ ДЛЯ УЧЕТА РАДИАЦИОННЫХ И НИЗКОТЕМПЕРАТУРНЫХ ЭФФЕКТОВ В СУБ-100-НМ МОП-ТРАНЗИСТОРНЫХ СТРУКТУРАХ
Authors: Петросянц К.О. , Исмаил-Заде М.Р. , Самбурский Л.М. , Харитонов И.А. , Силкин Д.С.
Published: February 2021

С использованием универсального подхода для суб-100-нм МОП-транзисторных структур были разработаны SPICE-модели с учетом радиационных и низкотемпературных эффектов, а также процедура идентификации параметров моделей на основе результатов натурного/машинного эксперимента. Подход состоит в комбинации макромоделирования на базе стандартной модели из состава SPICE-симулятора и введения дополнительных аналитических функций для радиационно-/температурно-зависимых параметров. Возможности разработанных SPICE-моделей и процедуры идентификации параметров проиллюстрированы на примерах расчета ВАХ суб-100-нм МОП-транзисторов.
РАСШИРЕНИЕ И ПРОБЛЕМАТИКА РАСШИРЕНИЯ ФУНКЦИОНАЛА ПОДДЕРЖКИ HDL-ЯЗЫКОВ В СОСТАВЕ САПР ПРОЕКТИРОВАНИЯ И МОДЕЛИРОВАНИЯ КОНФИГУРАЦИЙ ПЛИС
Authors: Малышев Н.М. , Рыбкин С.В. , Еремин А.С. , Варганов А.В. , Ярцев С.Ю.
Published: February 2021

В работе представлены вопросы и проблемы, а также их решения по увеличению количества поддерживаемых конструкций и правил языка Verilog, SystemVerilog в программном пакете проектирования и моделирования работы программируемых логических интегральных схем. Рассматриваются особенности разработки программного обеспечения для поддержки HDL-языков, такие как возникающие рекурсии, поддержка компиляционных директив, увеличивающее процессорное время ЭВМ при работе с ними и другие проблемы. Демонстрируются архитектурные решения, сквозного цикла проектирования программированных интегральных схем.
ГРАФОВАЯ МОДЕЛЬ ТРАФИКА В ПОДСИСТЕМАХ КОММУТАЦИИ СНК
Authors: Жезлов К.А. , Беляев А.А. , Путря Ф.М.
Published: February 2021

В представленной работе рассматривается проблема моделирования трафика в подсистемах коммутации СнК. Для ее решения предложена методика описания трафика в виде графа потоков данных, которая позволяет описывать однозначно воспроизводимые тестовые сценарии, направленные на выявление проблем производительности и является элементом методики анализа эффективности подсистем коммутации СнК.
АНАЛИЗ СХЕМ С КОЛЕБАТЕЛЬНЫМИ РЕЖИМАМИ С ИСПОЛЬЗОВАНИЕМ ОДНОШАГОВЫХ МЕТОДОВ ИНТЕГРИРОВАНИЯ ВЫСОКОГО ПОРЯДКА ТОЧНОСТИ
Authors: Гурарий М.М. , Жаров М.М. , Русаков С.Г. , Ульянов С.Л.
Published: February 2021

В работе предлагается алгоритм продолжения огибающих для анализа переходного процесса и установившегося периодического режима аналоговых интегральных схем. Для интегрирования уравнений огибающей с переменным шагом и порядком используются традиционные методы. Для интегрирования системы уравнений схемы на одном периоде предлагается использовать методы интегрирования порядка 1-4, полученные с помощью формулы Обрешкова. Приведены примеры анализа переходного процесса и периодического установившегося режима.
КРЕМНИЕВЫЕ PIN-ДИОДЫ ДЛЯ МОЩНЫХ СВЧ-УСТРОЙСТВ L- И S-ДИАПАЗОНОВ
Authors: Ахмелкин Д.М. , Ботов А.В.
Published: February 2021

Представлены результаты освоения технологии изготовления и корпусирования кремниевых pin-диодов. Описаны возможности применения выпускаемых pin-диодов и дана общая оценка организации серийного производства.
ИССЛЕДОВАНИЕ РАЗРАБОТАННОЙ КОНСТРУКЦИИ МИКРОМЕХАНИЧЕСКОГО СЕНСОРА ЛИНЕЙНЫХ УСКОРЕНИЙ ДЛЯ РЕГИСТРАЦИИ ПОЛОЖЕНИЯ ОБЪЕКТОВ
Authors: Лысенко И.Е. , Ежова О.А. , Ковалев А.В. , Науменко Д.В. , Ткаченко А.В.
Published: February 2021

Микромеханические сенсоры линейных ускорений находят широкое применение в современных инерциальных системах ориентации и навигации технических средств, применяемых в промышленности. В работе представлена разработанная конструкция МЭМС-сенсора линейных ускорений с тремя осями чувствительности, проведен модальный и статический анализ, найдены параметры конструкции, обеспечивающие равенство собственных частот по осям чувствительности, созданы и исследованы экспериментальные образцы.
ЭЛЕКТРОСЕЙСМОГИРОКАРДИОБЛОК ДЛЯ СКРИНИНГА ЗАБОЛЕВАНИЙ ЧЕЛОВЕКА
Authors: Ачильдиев В.М. , Грузевич Ю.К. , Солдатенков В.А. , Бедро Н.А. , Евсеева Ю.Н. , Комарова М.Н. , Рулев М.Е. , Успенский В.М.
Published: February 2021

Доклад посвящен возможностям метода скрининга заболеваний на основе информационного анализа электро-, гиро-и сейсмокардиосигналов и его модификации. Описаны параметры для информационного анализа кардиосигналов, проведен их сравнительный анализ на основе оценок коэффициента вариации и соотношения сигнал/шум.
РОБОТИЗИРОВАННАЯ ПЕРЧАТКА НА ОСНОВЕ СИСТЕМЫ МАГНИТОРЕЗИСТИВНЫХ СЕНСОРОВ ДЛЯ НЕЙРОРЕАБИЛИТАЦИИ ПАЦИЕНТОВ ПОСЛЕ ИНСУЛЬТА
Authors: Глаголев П.Ю. , Демин Г.Д.
Published: February 2021

Предложена концепция роботизированной перчатки на основе системы высокочувствительных магниторезистивных сенсоров для ускорения процедуры восстановления двигательных функций пациентов после инсульта. Разработан маршрут создания магнитных туннельных структур сенсоров состава Co60Fe20B20 / MgO / Co60Fe20B20, обеспечивающих детектирование угла поворота фаланг ниже 0,04 градуса.
АНАЛИЗ ОПЫТА СТРОИТЕЛЬСТВА ЛИНЕЙНО-КАБЕЛЬНЫХ СООРУЖЕНИЙ ТМК
Authors: Андреев В. , Бурдин В. , Попов Б. , Попов В.
Published: March 2021

Приводится анализ опыта строительства линейно-кабельных сооружений транспортной многоканальной коммуникации (ТМК), который показал, что многие необходимые нормативные документы по строительству таких ВОЛС, применению микрокабелей и микротрубок отсутствуют вообще, а некоторые действующие руководящие документы применить к новым технологиям невозможно. Обосновывается необходимость в разработке руководства по строительству линейно-кабельных сооружений ТМК. Предлагается перечень основных вопросов, которые должны быть рассмотрены в таком руководстве.
Enfermedad de Kikuchi en joven masculino sin antecedentes médicos. Causa inusual de fiebre de origen desconocido. Presentación de caso
Authors: Castillo Elianet , Blanco Claudia
Published: February 2021

Introducción: la enfermedad de Kikuchi, también llamada enfermedad Kikuchi–Fujimoto o linfadenitis necrotizante histiocítica es una condición benigna de etiología incierta que usualmente se presenta como fiebre de origen desconocido (FOD).

Objetivo: presentar un caso de un paciente joven que se ingresa en nuestro centro de salud con historia de fiebre de más de un mes, cefalea y adenopatías, que resultó ser la enfermedad de Kikuchi-Fujimoto.
EDITORIAL: Medicamentos para el Covid-19
Authors: Morla Elbi
Published: February 2021

No precisa de resumen.
Non-invasive monitoring of carboxyhemoglobin during hyperbaric oxygen therapy
Authors:   Dept of Anaesthesia, Hyperbaric Unit, Centre of Head and Orthopaedics, Copenhagen Univ Hosp, Rigshospitalet, Copenhagen, Denmark, Bidstrup Daniel , Ravn Frederikke , Smidt-Nielsen Isabel Guida , Wahl Anna Mygind , Jansen Erik Christian , Hyldegaard Ole
Published: February 2021

Introduction: This study aimed to assess the capability of a pulse CO-oximeter to continuously monitor carboxyhemoglobin (COHb) during hyperbaric oxygen (HBO2) therapy. We estimated limits of agreement (LOA) between blood gas analysis and pulse CO-oximeter for COHb during HBO2 therapy in patients suffering from acute CO poisoning. Furthermore, we did a medicotechnical evaluation of the pulse CO-oximeter in hyperbaric conditions. Method: We conducted a prospective, non-clinical, observational study in which we included n=10 patients with acute CO poisoning referred for HBO2 therapy. We did five repeated measurements of COHb for each patient during the HBO2 therapy. Bland-Altman analysis for multiple observations per individual was used to assess the agreement. The a priori LOA was ±6% for COHb. For the medicotechnical evaluation continuous measurements were obtained throughout each complete HBO2 therapy. The measurements were visually inspected and evaluated. Results: The Bland-Altman analysis showed that the pulse CO-oximeter overestimated COHb by 2.9 % [±1.0%] and the LOA was ±7.3% [±1.8%]. The continuous measurements by pulse CO-oximetry showed fluctuating levels of COHb and summarized saturations reached levels above 100%. Measurements were not affected by changes in pressure. Conclusion: To our knowledge, this study is the first to assess LOA and demonstrate use of a non-invasive method to measure COHb during HBO2 therapy. The pulse CO-oximeter performed within the manufactures reported LOA (±6%) despite hyperbaric conditions and was unaffected by changes in pressure. However, summarized saturations reached levels above 100%.
Treating allergic diseases in pregnancy
Authors: Pfaller Birgit , Bendien Sarah , Ditisheim Agnès , Eiwegger Thomas
Published: February 2021

Allergic diseases like asthma, allergic rhinitis, or food allergy have a
high prevalence in women of childbearing age and may affect up to 30%
of this age group. A multitude of immunological changes characterizes
pregnancy to create the optimal milieu for the unborn child. Both these
immunological changes and pre-conceptional, sub-optimal disease control
may affect the severity of the respective allergic disease
manifestations during pregnancy and pose a risk for mother and child.
Due to apparent limitations in conducting clinical trials, safety data
on anti-allergic drugs during pregnancy are limited. This lack of
clinical evidence demands to counsel between potential and known risks
and benefits of anti-allergic drugs. This includes the potential of
disease aggravation in the absence of treatment. By doing so, informed
decisions and shared decision-making is facilitated. In particular, in
patients with severe asthma, education about the risk of uncontrolled
asthma for mother and child should be part of regular care. This review
focuses on the management of allergic diseases during pregnancy,
maternal counseling, and available information/evidence regarding
allergic diseases’ management and treatment during pregnancy.
Furthermore, we discuss the challenges of treating patients with
allergic diseases and covid-19 during pregnancy.