bluuebunny/crossref_metadata_2025 huggingface dataset:
Regulation of caveolae through cholesterol-depletion dependent tubulation by PACSIN2/Syndapin II
Authors: Gusmira Aini , Takemura Kazuhiro , Lee Shin Yong , Inaba Takehiko , Hanawa-Suetsugu Kyoko , Oono-Yakura Kayoko , Yasuhara Kazuma , Kitao Akio , Suetsugu Shiro
Published: September 2020

The membrane shaping ability of PACSIN2 via its F-BAR domain has been shown to be essential for caveolar morphogenesis, presumably through the shaping of the caveolar neck. Caveolar membrane contains abundant cholesterol. However, the role of cholesterol in PACSIN2-mediated membrane deformation remains unclear. We show that the binding of PACSIN2 to the membrane could be negatively regulated by cholesterol. We prepared a reconstituted membrane based on the lipid composition of caveolae. The reconstituted membrane with cholesterol had a weaker affinity to the F-BAR domain of PACSIN2 than the membrane without cholesterol. Consistently, the depletion of cholesterol from the plasma membrane induced the PACSIN2-localized tubules with caveolin-1 at their tips, suggesting that cholesterol inhibited the membrane tubulation by PACSIN2. The tubules induced by PACSIN2 were suggested to be an intermediate of caveolae endocytosis. Consistently, the removal of caveolae from the plasma membrane upon cholesterol depletion was diminished in the PACSIN2-deficient cells. These data suggested that PACSIN2 mediated caveolae internalization dependently on the amount of cholesterol, providing a mechanism for cholesterol-dependent regulation of caveolae.
Increased supraorganization of respiratory complexes is a dynamic multistep remodelling in response to proteostasis stress
Authors: Rawat Shivali , Ghosh Suparna , Mondal Debodyuti , Anusha Valpadashi , Raychaudhuri Swasti
Published: September 2020

Proteasome-mediated degradation of misfolded proteins prevents aggregation inside and outside mitochondria. But how do cells safeguard the mitochondrial proteome and mitochondrial functions despite increased aggregation during proteasome inactivation? Here, using a novel two-dimensional complexome profiling strategy, we report increased supraorganization of respiratory complexes (RCs) in proteasome-inhibited cells that occurs simultaneously with increased pelletable aggregation of RC subunits inside mitochondria. Complex II (CII) and complex V (CV) subunits are increasingly incorporated into oligomers. Complex I (CI), complex III (CIII) and complex IV (CIV) subunits are engaged in supercomplex formation. We unravel unique quinary states of supercomplexes during early proteostatic stress that exhibit plasticity and inequivalence of constituent RCs. The core stoichiometry of CI and CIII is preserved, whereas the composition of CIV varies. These partially disintegrated supercomplexes remain functionally competent via conformational optimization. Subsequently, increased stepwise integration of RC subunits into holocomplexes and supercomplexes re-establishes steady-state stoichiometry. Overall, the mechanism of increased supraorganization of RCs mimics the cooperative unfolding and folding pathways for protein folding, but is restricted to RCs and is not observed for any other mitochondrial protein complexes.

This article has an associated First Person interview with the first author of the paper.
Amalgam regulates the receptor tyrosine kinase pathway through Sprouty in glial cell development
Authors: Ariss Majd M. , Terry Alexander R. , Islam Abul B. M. M. K. , Hay Nissim , Frolov Maxim V.
Published: September 2020

The receptor tyrosine kinase (RTK) pathway plays an essential role in development and disease by controlling cell proliferation and differentiation. Here, we profile the Drosophila larval brain by single cell RNA-sequencing and identify Amalgam (Ama), encoding a cell adhesion protein of the immunoglobulin IgLON family, that regulates the RTK pathway activity during glial cell development. Depletion of Ama reduces cell proliferation, affects glial cell type composition and disrupts the blood-brain barrier (BBB) that leads to hemocyte infiltration and neuronal death. We show that Ama depletion lowers RTK activity by upregulating Sprouty (Sty), a negative regulator of RTK pathway. Knockdown of Ama blocks oncogenic RTK signaling activation in the Drosophila glioma model and halts malignant transformation. Finally, knockdown of a human ortholog of Ama, LSAMP, results in upregulation of SPOUTY2 in glioblastoma cell lines suggesting that the relationship between Ama and Sty is conserved.
High-throughput multiplexed tandem repeat genotyping using targeted long-read sequencing
Authors: Ganesamoorthy Devika , Yan Mengjia , Murigneux Valentine , Zhou Chenxi , Cao Minh Duc , Duarte Tania P. S. , Coin Lachlan J. M.
Published: September 2020

Background: Tandem repeats (TRs) are highly prone to variation in copy numbers due to their repetitive and unstable nature, which makes them a major source of genomic variation between individuals. However, population variation of TRs has not been widely explored due to the limitations of existing approaches, which are either low-throughput or restricted to a small subset of TRs. Here, we demonstrate a targeted sequencing approach combined with Nanopore sequencing to overcome these limitations.

Methods: We selected 142 TR targets and enriched these regions using Agilent SureSelect target enrichment approach with only 200 ng of input DNA. We barcoded the enriched products and sequenced on Oxford Nanopore MinION sequencer. We used VNTRTyper and Tandem-genotypes to genotype TRs from long-read sequencing data. Gold standard PCR sizing analysis was used to validate genotyping results from targeted sequencing data. 

Results: We achieved an average of 3062-fold target enrichment on a panel of 142 TR loci, generating an average of 97X coverage per sample with 200 ng of input DNA per sample. We successfully genotyped an average of 75% targets and genotyping rate increased to 91% for the highest-coverage sample for targets with length less than 2 kb, and GC content greater than 25%. Alleles estimated from targeted long-read sequencing were concordant with gold standard PCR sizing analysis and highly correlated with alleles estimated from whole genome long-read sequencing.

Conclusions: We demonstrate a targeted long-read sequencing approach that enables simultaneous analysis of hundreds of TRs and accuracy is comparable to PCR sizing analysis. Our approach is feasible to scale for more targets and more samples facilitating large-scale analysis of TRs.
Prevalence and determinants of unmet family planning needs among women of childbearing age in The Gambia: analysis of nationally representative data
Authors: Barrow Amadou , Jobe Amienatta , Okonofua Friday
Published: September 2020

Background: Family planning is imperative in the control of population growth by preventing unintended pregnancies and reducing other pregnancy-related risks. However, the effectiveness of family planning is constrained by unmet needs. This study determined the proportion and identify factors associated with unmet family planning needs among women of childbearing age in The Gambia.

Methods: We utilized cross-sectional population-based Demographic and Health Survey (DHS) data from Gambian women aged 15-49 years in 2013. The outcome measured was the total unmet/met need for FP.  The sample comprised 10,233 women aged 15-49 years old. Chi-square and multivariable logistic regression analysis were used.

Results: Of the 10,233 eligible women recruited in the study, the mean age was 27.4±9.1 years while 67.5% were married. Overall, 17.6% of women reported unmet FP need, of whom 14.0% and 3.6% reported unmet birth spacing and birth limitation needs, respectively. The women's age, region, ethnicity, number of live children, number of household/family members, the optimal number of children, and husband/partners’ desire for the children were found as significant determinants of unmet FP needs. Furthermore, breastfeeding has been identified as the key reason for the non-use of FP in mothers.

Conclusions: The study findings suggest a need to expand FP programs and related strategic communications especially for younger women in order to improve their contraceptive prevalence. Improving women empowerment and accessibility to FP will help to lessen the current trend towards rising unmet needs in The Gambia.
Impact of virtual reality game therapy and task-specific neurodevelopmental treatment on motor recovery in survivors of stroke
Authors: Kaur Alisha , Balaji Gandhi Karunanithi , Sahana A , Karthikbabu Suruliraj
Published: September 2020

Background/Aims

This study aimed to compare the impact of virtual reality game therapy and task-specific neurodevelopmental training on the motor recovery of upper limb and trunk control, as well as physical function, in people who have had a stroke.

Methods

This randomised, assessor-blinded clinical trial was conducted with 34 patients with post-stroke duration of 135 ± 23 days. Patients with first-onset cortical stroke aged 40–60 years, Mini-Mental State Examination score >20, ability to complete a nine-hole peg test within 120 seconds, ability to lift the affected arm at shoulder level and independent standing were included. Patients were excluded if they had unilateral neglect and musculoskeletal injuries of the affected limb in the past 2 months. Outcome measures used were the Fugl-Meyer Upper Extremity Scale, Action Research Arm Test, Trunk Impairment Scale and Stroke Impact Scale-16. The virtual reality game therapy group performed interactive table tennis, boxing and discus throwing games. The neurodevelopmental treatment group underwent task-specific movements of the upper limb in sitting and standing. All patients performed 45 minutes of treatment, 5 days a week for 4 weeks.

Results

Both groups showed improvements in all measures after training (P<0.05). There was a between-group difference of 3.47 points in Fugl-Meyer Upper Extremity Scale in favour of the virtual reality game therapy.

Conclusions

Both treatment regimens resulted in equal improvements in hand dexterity and trunk control after stroke. Virtual reality game therapy improved the upper limb motor recovery of stroke survivors to a greater extent than neurodevelopmental treatment.
Surgical site infection after hip fracture surgery
Authors: Masters James , Metcalfe David , Ha Joon Soo , Judge Andrew , Costa Matthew L.
Published: September 2020

Aims

This study explores the reported rate of surgical site infection (SSI) after hip fracture surgery in published studies concerning patients treated in the UK.

Methods

Studies were included if they reported on SSI after any type of surgical treatment for hip fracture. Each study required a minimum of 30 days follow-up and 100 patients. Meta-analysis was undertaken using a random effects model. Heterogeneity was expressed using the I2 statistic. Risk of bias was assessed using a modified Newcastle-Ottawa Scale (NOS) system.

Results

There were 20 studies reporting data from 88,615 patients. Most were retrospective cohort studies from single centres. The pooled incidence was 2.1% (95% confidence interval (CI) 1.54% to 2.62%) across ‘all types’ of hip fracture surgery. When analyzed by operation type, the SSI incidences were: hemiarthroplasty 2.87% (95% CI 1.99% to 3.75%) and sliding hip screw 1.35% (95% CI 0.78% to 1.93%). There was considerable variation in definition of infection used, as well as considerable risk of bias, particularly as few studies actively screened participants for SSI.

Conclusion

Synthesis of published estimates of infection yield a rate higher than that seen in national surveillance procedures. Biases noted in all studies would trend towards an underestimate, largely due to inadequate follow-up.
POLÍTICA NACIONAL DE RESÍDUOS SÓLIDOS E SUAS IMPLICAÇÕES NA CADEIA DA LOGÍSTICA REVERSA DE MICROCOMPUTADORES NO BRASIL
Authors: Demajorovic Jacques , Migliano João Ernesto Brasil
Published: September 2020

A Política Nacional de Resíduos Sólidos obriga o setor de microcomputadores a implantar a logística reversa por meio de acordos setoriais. Este artigo teve como objetivo discutir os principais desafios e perspectivas para a implementação da logística reversa na cadeia de suprimentos de microcomputadores no mercado brasileiro. Os procedimentos metodológicos privilegiam a realização de entrevistas em profundidade com representantes da cadeia reversa que compõem o acordo setorial previsto em Lei. Resultados dessa investigação indicam a importância da aprovação da PNRS e da potencialização do diálogo entre os vários membros da cadeia de eletroeletrônicos por meio dos acordos setoriais. Identificou-se também a resistência das empresas em entender a logística reversa como uma oportunidade de novos modelos de negócios e a ausência de tecnologia no Brasil para recuperar materiais mais valiosos presentes nos microcomputadores. Entraves para a integração das cooperativas de catadores nas atividades de destinação de microcomputadores também foram identificados.
Estimation of maximum temperature and thermal crosstalk between two active elements in a PIC: development of a thermal equivalent circuit
Authors: Kyatam Shusmitha , Maslovski Stanislav I. , Neto Hugo , Alves Luis N. , Mendes Joana C.
Published: September 2020

The operating temperature plays a key role in the performance and lifetime of photonic integrated circuits (PICs). Miniaturization and increasing heat dissipation promote thermal crosstalk effects and pose additional challenges to the PIC designer. The European Photonics Industry Consortium recommends thermal modeling during design phase. However, a fully numerical optimization of a particular layout requires an unrealistically large number of simulations. Here, we propose a compromise approach: a set of carefully chosen simulations are performed with a multi-physics software. The obtained results are used to derive a linearized equivalent thermal circuit that can be used to maximize the power levels and to minimize the distance between the chosen components while guaranteeing the absence of a thermal crosstalk. For simplification, this model is derived considering a PIC with only two active components. Other parameters are varied, such as the material of the holder (silicon or diamond) and the layer of epoxy that is used to attach the PIC to the holder. The obtained circuit is used to determine the maximum dissipated power or the minimum distance between the components while keeping some predetermined specifications. The model can be extended to contain more elements or to include transient analysis of the temperature distribution.
Spectral intensity correlations of backscattered diffuse light: the effect of scattering anisotropy
Authors: Duran-Ledezma Angel A. , De La Cruz-Burelo Hugo A. , Rojas-Ochoa Luis F.
Published: September 2020

In this work, we report experiments and a theoretical scheme of photon transport in the frequency domain of rigid turbid media. We have employed spectral multi-speckle intensity correlations to estimate optical properties as the transport mean free path and the absorption length of turbid systems. We propose a scheme based on the photon diffusion model using an effective path-length distribution in the backscattering configuration and take explicitly into account the particles scattering anisotropy parameter

g

. By studying rigid Teflon slabs and polymer matrices doped with polystyrene particles of different degrees of scattering anisotropy, we find that the proposed model adequately describes our experimental results. Our hypothesis for the diffuse transport of backscattered photons in the weak multiple scattering regime is further validated using a numerical simulation scheme of speckle dynamics, based on the Copula method.
Simplification method for 3D Terracotta Warrior fragments based on local structure and deep neural networks
Authors: Geng Guohua , Liu Jie , Cao Xin , Liu Yangyang , Zhou Wei , Zhao Fengjun , Su Linzhi , Li Kang , Zhou Mingquan
Published: September 2020

The emergence of the three-dimensional (3D) scanner has greatly benefited archeology, which can now store cultural heritage artifacts in computers and present them on the Internet. As many Terracotta Warriors have been predominantly found in fragments, the pre-processing of these fragments is very important. The raw point cloud of the fragments has lots of redundant points; it requires an excessively large storage space and much time for post-processing. Thus, an effective method for point cloud simplification is proposed for 3D Terracotta Warrior fragments. First, an algorithm for extracting feature points is proposed that is based on local structure. By constructing a k-dimension tree to establish the k-nearest neighborhood of the point cloud, and comparing the feature discriminant parameter and characteristic threshold, the feature points, as well as the non-feature points, are separated. Second, a deep neural network is constructed to simplify the non-feature points. Finally, the feature points and the simplified non-feature points are merged to form the complete simplified point cloud. Experiments with the public point cloud data and the real-world Terracotta Warrior fragments data are designed and conducted. Excellent simplification results were obtained, indicating that the geometric feature can be preserved very well.
Invasive optical pumping for room-temperature masers, time-resolved EPR, triplet-DNP, and quantum engines exploiting strong coupling
Authors: Wu Hao , Mirkhanov Shamil , Ng Wern , Chen Kuan-Cheng , Xiong Yuling , Oxborrow Mark
Published: September 2020

We explore an approach for optically pumping a body of optically dense magnetic material. This challenge arises in time-resolved electron paramagnetic resonance (TREPR), triplet-based dynamic nuclear polarisation (DNP), and cavity QED. Crystals of pentacene-doped p-terphenyl were grown around variously shaped ends of optical waveguides, through which pump light could be injected deeply into the crystal. When incorporated into a maser as the gain medium, we found that, compared to conventional side-pumping, 11 times less pump beam intensity was needed to reach the masing threshold and 54 times more pulse energy could be absorbed by the gain medium without damage, resulting in a record peak output power of -5 dBm.
Lithography-free flexible perfect broadband absorber in visible light based on an all-dielectric multilayer structure
Authors: Zhao Jiancun , Wang Yan , Zhu Yechuan , Zhang Wei , Yu Yiting
Published: September 2020

A flexible broadband absorber based on an all-dielectric multilayer structure is proposed to get an average absorbance of 97.4%, covering the whole visible light. Additionally, such high absorption presents an extraordinary angular tolerance of up to

±

50

∘

. Due to the single broadband resonance in the highly lossy Fabry–Perot (F–P) cavity and the intrinsic loss property of Ge, the proposed multilayer structure achieves the broadband absorption effect. Furthermore, the simple all-dielectric multilayer configuration requires no noble metal, making the lithography-free, large-scale, cost-effective manufacturing process feasible. Meanwhile, the good substrate adaptation facilitates its preparation on a flexible substrate. Accordingly, a three-dimensional object covered by the proposed flexible absorber can be treated as a two-dimensional black hole, revealing the effect of stealth. The proposed perfect absorber shows potentials for camouflage coating, solar energy collection, flexible optoelectronics, and other fields.
Compact deep ultraviolet frequency-doubled Tb:LiYF4 lasers at 272 nm
Authors: Chen Hengjun , Uehara Hiyori , Yasuhara Ryo
Published: September 2020

A new laser system has been developed to generate coherent deep ultraviolet (DUV) radiation at 272 nm. The DUV lasers were produced via intra-cavity frequency doubling of the

T
b

3
+

:

L
i
Y
F

4

lasers emitting fundamentally at 544 nm. Continuous-wave (cw) and

Q

-switched operations were performed with a type I phase-matched

β
−

B
a
B

2

O

4

nonlinear crystal. The cw operation produces 127 mW of averaged DUV output power. Passive

Q

-switched operation was realized by using

C
o

2
+

:

M
g
A
l

2

O

4

saturable absorbers. At an initial transmittance (excluding Fresnel reflections) of 99% at 544 nm, stable pulsed output at 272 nm with maximum single-pulse energy of 7.6 µJ and peak power of 6.1 W was obtained. Furthermore, by employing a smaller initial transmittance of 94.7%, we achieved maximum averaged DUV output power of 277 mW. The statistically averaged single-pulse DUV energy and peak power were estimated to be around 100 µJ and 320 W, respectively, which indicates great potential for this DUV laser system toward high energy and peak power.
Spatial pattern-shifting method for complete two-wavelength fringe projection profilometry: erratum
Authors: Lin Chu , Zheng Dongliang , Kemao Qian , Han Jing , Bai Lianfa
Published: September 2020

We present an erratum and generalization to our Letter [Opt. Lett.
45, 3115 (2020)OPLEDP0146-959210.1364/OL.392102]. This
erratum corrects an error in Eq. (12), and the generalization converts

R
h

to

k
h

for more general situations of
wavelengths. Neither has any influence on the conclusions of the
original Letter.
TE/TM-pass polarizers based on lateral leakage in a thin film lithium niobate–silicon nitride hybrid platform: publisher’s note
Authors: Liu Yang , Huang Xingrui , Li Zezheng , Kuang Yingxin , Guan Huan , Wei Qingquan , Fan Zhongchao , Li Zhiyong
Published: September 2020

This publisher’s note contains a correction to Opt. Lett. 45, 4915 (2020)OPLEDP0146-959210.1364/OL.404197.
Curating climate change: The Taipei Biennial as an environmental problem solver
Authors: Chao Jenifer , Kompatsiaris Panos
Published: September 2020

This article analyses the curatorial practices behind the 2018 Taipei Biennial by considering its ethos of public engagement that fostered a merging of artistic means and civic aims. Entitled ‘Post-Nature: A Museum as an Ecosystem’, the biennial confronted the timely theme of environmental precarity and positioned itself as a substantive stakeholder in the public debate on climate change. It mobilized the biennial platform to marshal artists, community groups, conservationists and others to spur on new thinking and, perhaps more importantly, to create solutions. By adopting this new role as an environmental problem solver, the biennial expanded itself from the ensconced space of aesthetic inquiry and sought to generate new forms of institutional relations and to nurture in its audience an ecological consciousness. These exhibition strategies underscore many international biennials’ self-assigned mandates to claim a socially relevant role and to adopt an interventionist posture. But while the biennial showcased multifaceted ecological visions of the present, it also delimited its range of critique and the possible modes of collective action. In this way, the exhibition becomes a valuable searchlight into the social and political relevance of global biennials, as well as their contention for legitimacy and significance as agents of social transformation.
Market Orientation, Competitive Advantage and Marketing Performance of Small Medium Enterprises (SMEs)
Authors: Puspaningrum Astrid
Published: September 2020

This study aims to analyze competitive advantage as a variable that mediates the effect of market orientation on marketing performance. This research population is 113,000 SMEs (Small And Medium Enterprises) located in Malang City, which are engaged in food processing, handicrafts, and clothing business units with an observation sample of 100 SMEs. The data analysis technique used in this study is Structural Equation Modeling. The results of this study indicate that SMEs' performance will increase if they can carry out processes and activities related to creating and satisfying customer needs. Besides, market-oriented SMEs contribute to competitive advantage by creating product uniqueness, product quality, and competitive prices, ultimately affecting the performance of SMEs. In order to improve SMEs' performance, efforts must be made to develop marketing strategies, such as paying attention to market orientation, focusing on customer orientation, competitor orientation, and inter-functional coordination, and developing or innovating new products.
Experience-Dependent Counselor-Client Brain Synchronization during Psychological Counseling
Authors: Zhang Ya , Meng Tian , Yang Yaxi , Hu Yi
Published: September 2020

The role of the counselor’s experience in building an alliance with the clients remains controversial. Recently, the expanding nascent studies on interpersonal brain synchronization (IBS) using functional near-infrared spectroscopy (fNIRS) on human subjects have hinted at the possible neural substrates underlying the relationship qualities between the counselor-client dyads. Our study assessed the clients’ self-report working alliance (WA) as well as simultaneously measured IBS by fNIRS in 14 experienced versus 16 novice counselor-client dyads during the first integrative-orientation psychological counseling session. We observed that synchronous brain activity patterns were elicited from the right temporo-parietal junction (rTPJ) across counselor-client dyads. Furthermore, such IBS, together with alliance quality, was especially evident when counselors had more psychotherapy experience. Time-lagged counselor-client brain synchronization might co-vary with the alliance (goal component) when the client’s brain activity preceded that of the counselor. These findings favor the notion that the IBS between counselor-client associated with the WA is an experience-dependent phenomenon, suggesting that a potential adaptive mechanism is embedded in psychological counseling.
Perfil del consumidor de suplementos nutricionales de las sedes de los gimnasios de la USTA en Bogotá
Authors: Duarte Gomez Johann Sebastian
Published: September 2020

Objetivo.En Colombia existe un creciente interés por consumir suplementos, sin conocimiento de sus efectos; por ello, es indispensable conocer el perfil del consumidor que asiste a los gimnasios de la USTA en Bogotá. El objetivo fue determinar el perfil del consumidor de suplementos nutricionales en edades de 15 a 35 años en los gimnasios de las sedes de la USTA, a través de la aplicación de un cuestionario de 19 preguntas abiertas y cerradas a 100 voluntarios hombres y mujeres, asistentes a estos gimnasios. Método.Cuantitativo.Resultados y discusión. Se esperaban caracterizar el uso de la suplementación en sedes de gimnasios de la USTA; confirmar que los hombres consumen más suplementos; prefieren batidos proteicos para aumentar su masa muscular. Además, las mujeres consumen principalmente vitaminas y agentes lipolíticos para disminución de masa grasa. Por último, se identificó que un alto porcentaje cree que el consumo de suplementos les ayuda a cumplir sus objetivos.Conclusión.Se conoció que un número considerable de personas que asiste regularmente a gimnasios consume suplementos sin orientación especializada y sin tener que utilizarlos realmente, pero es necesario regular el uso irracional y potencialmente inseguro de los suplementos nutricionales en mejora del rendimiento físico.
Aportes para la comprensión de la historia de la edad media desde el horizonte de la utopía social cristiana
Authors: Martínez Gerardo
Published: September 2020

Este artículo presenta una visión histórica de la utopía social cristiana en la Edad Media.Se pone de presente que la praxis social y religiosa conducida por la Iglesiainstitucional en ese periodo de tiempo está relacionada con una crisis u ocaso de lautopía social cristiana, entendida ésta como la búsqueda de una sociedad en la queimpere la igualdad social y religiosa, que se rija por el principio de misericordia, y queesté abierta no sólo a los elegidos (como se sentía el pueblo judío), sino a todos los sereshumanos, con especial predilección por los pobres, como primeros destinatarios delmensaje cristiano. Se presenta la Edad Media como un periodo de tiempo que se guiópor una mentalidad religiosa y una praxis económica y social que ocultó la utopía, lacual resurgió en el humanismo y en algunas prácticas evangelizadoras en el NuevoMundo.
Visión del hombre latinoamericano y la idea de educación en Fernando González Ochoa
Authors: Rincón Rojas Diego Alejandro
Published: September 2020

Del maestro Fernando González Ochoa se han dicho y escrito muchas cosas. Se le hatildado de ateo, rebelde, mal hablado; pero se olvida que fue un místico que buscó llegara una comunión con la Intimidad (Dios), un hombre amante de la vida; se olvida sulabor de maestro de escuela que quiso formar hombres auténticos, sacándolos de suvida de rebaño y dándoles el lugar que se merecen. El presente trabajo tiene como objetivo,a partir de la lectura de algunas de sus obras, indagar sobre el pensamientoantropológico y educativo del maestro Fernando González Ochoa. Presento al lector alFernando González que encontré a lo largo de mi lectura de sus obras y del diversomaterial consultado para este trabajo. He sido lo más fiel posible a su pensamiento,realizando una actividad hermenéutica en la que busco presentar la comprensión propiadel autor ante el contexto que le tocó vivir, el cual le sirvió de pretexto para escribir sustextos.
MARIA CANO: LA ENDEBLEZ DE UN SÍMBOLO
Authors: Ramírez Aíssa Carlos
Published: September 2020

Se aborda el estudio del film a partir del concepto de género cinematográfico, después la forma narrativa, la puesta en escena y el plano, interrelacionando los tres aspectos, para intentar a través del cómo capturar el qué o significado fílmico, y comentar la imagen depresiva ofrecida por la directora de una congénere que simboliza el modo diferente de ser mujer en la historia de Colombia.
Derecho a la atención sanitaria para madres y menores de 18 años afectados con labio y/o paladar hendido en República Dominicana
Authors: Maldonado Maldonado Lorena Alexandra , Morales Borrero María Carolina , Guadalupe Silva María
Published: September 2020

Objetivo: identificar y describir, desde la perspectiva del derecho fundamental a la salud, la garantía de la atención sanitaria en menores dominicanos afectados con labio y/o paladar hendido (LPH) y sus madres. Métodos: en tanto este es un estudio descriptivo, se realizaron encuestas semiestructuradas y se aplicó la observación no participante en los territorios de residencia de familias con menores afectados por LPH, atendidos en una fundación de República Dominicana. Resultados: la mayoría de familias afectadas por LPH pertenecen a clases sociales vulnerables con limitada capacidad de pago para adquirir seguros de salud. De las 39 familias abordadas, 26 madres no contaron con seguro de salud durante la gestación, pero los 39 pacientes con LPH sí contaban con algún tipo de aseguramiento. Se evidenció negación sistemática en la prestación de  servicios sanitarios, barreras administrativas, invisibilización de la problemática del LPH en los servicios de salud y en definitiva, un sistema de salud excluyente en la práctica. Conclusión: pese a que la atención sanitaria a gestantes y menores de 18 años se reconoce constitucionalmente como un derecho fundamental a cargo del Estado, la forma en que opera el sistema de salud dominicano supedita la atención a la capacidad de pago de las familias, lo que genera inequidades sociales y sanitarias que vulneran el goce efectivo del derecho a la salud de las madres y los menores que nacen con LPH.
Craneoplastía con implante de polimetilmetacrilato (PMMA) para corregir secuela de trauma. Reporte de caso
Authors: Ramírez García Jorge Omar , Campos Ramírez Lidia Araceli , Ernesto Lucio Leonel José Leandro , Uribe Campos Alfonso , Benavides Ríos Alejandro , Miranda Villasana José Ernesto
Published: September 2020

Introducción: los defectos del cráneo y las anomalías del hueso craneofacial que requieren reconstrucción son comunes en una variedad de procedimientos neuroquirúrgicos. Después de una craniectomía o de fracturas craneofaciales posteriores a traumatismos cráneoencefálicos, los pacientes pueden desarrollar defectos cosméticos importantes. Algunos de estos son la depresión de la piel y un defecto de hundimiento que lleva a una apariencia asimétrica de la cabeza, sin dejar de lado las repercusiones físicas, neurológicas y psicológicas que estas lesiones conllevan. La reconstrucción craneofacial y la craneoplastía tienen una larga historia, pero las nuevas técnicas quirúrgicas y una multitud de opciones de materiales han impulsado recientemente el avance en esta área. Los implantes de polimetilmetacrilato (PMMA) han demostrado ser estables, biocompatibles, no conductores, radiotransparentes y de bajo costo. Es así que se pueden colocar y modificar fácilmente, con lo que se elimina la morbilidad del sitio donante. Presentación del caso: en este artículo presentamos un caso de craneoplastía de defecto frontal, posterior a traumatismo, cuya reconstrucción fue realizada mediante una prótesis de polimetilmetacrilato (PMMA) en el Hospital General Xoco de la Cuidad de México. Conclusión: se reporta la reducción del tiempo quirúrgico, además de un costo de la prótesis accesible para el paciente; de esta manera, se obtuvieron resultados satisfactorios y mejoras en el contorno estético facial, en tanto se permitió cobertura y protección para el tejido encefálico.La reconstrucción craneofacial y la craneoplastía tienen una larga historia, pero las nuevas técnicas quirúrgicas y una multitud de opciones de materiales han impulsado recientemente el avance en esta área.1 Los implantes de polimetilmetacrilato (PMMA) han demostrado ser estables, biocompatibles, no conductores, radiotransparentes y de bajo costo.6 Se pueden colocar y modificar fácilmente y se elimina la morbilidad del sitio donante. En este artículo presentamos un caso de craneoplastía de defecto frontal posterior a traumatismo realizada mediante una prótesis de polimetilmetacrilato (PMMA) en el Hospital General Xoco de la Cuidad de México, con la cual se logró reducir el tiempo quirúrgico, además el costo de la prótesis fue accesible para el paciente y se obtuvieron resultados satisfactorios.
Neuroimmun-moduláció az emésztőcsatorna nyálkahártyájában
Authors: Fehér Erzsébet , Altdorfer Károly
Published: September 2020

Absztrakt:

Az enteralis idegrendszerben termelt neuropeptidek szerepet játszanak az
immunsejtek működésében, részt vesznek a gyulladás fokozásában és annak
csökkentésében. Összefoglaló munkánkban azt elemeztük, hogy a gyulladás milyen
hatást fejt ki az idegelemek és immunsejtek neuropeptid-tartalmára. Gyulladásos
mintákat (human gastritis, állatkísérletes indukált colitis, sztreptozotocinnal
indukált diabetes mellitus) és kontrollpreparátumokat hasonlítottunk össze. A
neuropeptid-tartalmú idegrostok és immunsejtek mennyiségét vizsgáltuk
(immunhisztokémia, konfokális lézermikroszkópia, elektronmikroszkópia),
esetleges közeli kapcsolatokat kerestünk. Gyulladásos folyamatokban (gastritis,
kísérletes colitis, diabetes mellitus) a substance P, neuropeptid Y és vasoactiv
intestinalis peptid pozitív idegrostok mennyisége szignifikánsan megemelkedett,
s ezzel párhuzamosan a nyálkahártyában lévő immunkompetens sejtek (lymphocyták,
plazmasejtek, hízósejtek) száma szintén jelentős mértékben megnőtt (p<0,001).
Gyulladás hatására az immunsejtek aktiválódtak és pozitívan jelölődtek substance
P, neuropeptid Y és vasoactiv intestinalis peptid elleni antitestekkel.
Kontrollanyagban sohasem sikerült nagyon közeli idegrost-immunsejt közötti
morfológiai kapcsolatot kimutatni, viszont gyulladás hatására számos immunsejt
mellett található idegrostköteg, ahol az idegrostok egy része immunpozitivitást
mutat substance P-re, neuropeptid Y-ra és vasoactiv intestinalis peptidre.
Konfokális lézermikroszkóppal kettős jelöléssel bizonyítottuk, hogy
tumornekrózisfaktor-alfa- és nukleárisfaktor-kappa-B-pozitív immunsejtek egy
részében a substance P kolokalizációban fordul elő. A tumornekrózisfaktor-alfa
és nukleárisfaktor-kappa-B-pozitív immunsejtek mennyiségének emelkedése
korrelált (párhuzamosan emelkedett) a substance P-immunreaktív idegrostok
mennyiségének növekedésével human gastritisben. Eredményeink alátámasztják, hogy
substance P-antagonisták vagy neuropeptid Y és vasoactiv intestinalis peptid
alkalmazása az utóbbi évtizedben új terápiás lehetőség lehet a krónikus
gyulladások kezelésére. Orv Hetil. 2020; 161(35): 1436–1440.
Religious Boundaries for Sex, Gender, and Corporeality By A. Cuffel, A. Echevarria, and G. T. Halkias (eds) (2019)
Authors: Pati George
Published: September 2020

Religious Boundaries for Sex, Gender, and Corporeality By A. Cuffel, A. Echevarria, and G. T. Halkias (eds) (2019) London: Routledge, 196pp.
Proposição e aplicação de um modelo de gerenciamento de projetos em uma empresa de consultoria
Authors: Kravicz Corchak Carlos Augusto , Fernandes Gasques Ana Carla
Published: September 2020

A constante busca das organizações pela melhoria de seus processos garante a oportunidade para empresas de consultoria executarem seus serviços e, para que estes tenham qualidade, deve ser avaliada a melhor forma de gerenciar projetos bem como identificada a metodologia mais apropriada para tal. Assim, o objetivo consistiu em elaborar um modelo para gerenciamento de projetos em uma empresa de consultoria. Foi realizado um estudo de caso, cujos procedimentos foram contextualizar o cenário atual, adaptar modelos de referência envolvendo métodos ágeis e PMCanvas e identificar uma ferramenta para gerenciamento visual a partir do modelo criado e aplica-lo. Os resultados obtidos incluem o levantamento das necessidades com relação ao gerenciamento de projetos, um checklist de ferramentas e atividades de métodos existentes, o desenho do modelo e sua aplicação em um projeto de transformação e automação de processos de um cliente. Por fim, conclui-se que o modelo possibilita um padrão de organização para a empresa de consultoria, proporcionando estruturação de novos processos como planejamento, monitoramento e encerramento além de tornar os projetos e processos mais visuais.
Relationship between soy productive chain, circular economy, precision agriculture, and no-tillage planting system
Authors: Silva Karoline Arguelho , De Araújo Motomiya Anamari Viegas , Melo Isotilia Costa , Ferraz Diogo , Do Nascimento Rebelatto Daisy Aparecida
Published: September 2020

Despite the relevance of these themes for the soy production chain, No-Tillage System, Precision Agriculture, and Circular Economy (CE) are still little studied jointly in the Brazilian context. Less focus has been given to the relationship between the three concepts so far. For this reason, this paper aimed to analyze the contribution of Precision Agriculture and No-Tillage to the achievement of the CE, through the mapping of soy production. The method used was the literature review of the specialized references and the case study, to demonstrate the possibility of a more sustainable production system in a rural property in the state of Mato Grosso do Sul. The results showed that the application of the CE generated better use of the production residues, in addition to the reduction of agricultural inputs used in the rural property. Consequently, it was found that the application of these concepts made the business more profitable for the rural producer.
Comprensión Narrativa: Análisis del Concepto y una Propuesta Metodológica
Authors: Flores Eileen Pfeiffer , Rogoski Bianca da Nóbrega , Nolasco Anny Caroline Gomes
Published: September 2020

Resumen El análisis conceptual es un eje metodológico de la investigación científica. Aunque un concepto a menudo sufre cambios como parte de una teoría, el análisis de su operación lógica original es condición previa para comprender estos cambios y evaluar su utilidad. Se analizó el funcionamiento lógico del concepto de comprensión, con fundamento en técnicas de la Filosofía del Lenguaje Ordinario. Son características lógicas importantes del concepto: (1) comprender es un verbo de logro (2) puede haber diferentes grados de logro (3) es un concepto polimórfico y (4) es un concepto disposicional. Son discutidas implicaciones metodológicas y teóricas de este análisis, ejemplificadas con una propuesta para el análisis de la comprensión de textos narrativos.
Pensando a Homoparentalidade: Um Estudo Qualitativo com Jovens Adultos Portugueses sem Filhos
Authors: Xavier Paula , Alberto Isabel , Mendes Francisco
Published: September 2020

Resumo: O momento atual caracteriza-se por importantes mudanças sociais e legais, com potenciais repercussões na vida de pessoas lésbicas e gays. O presente estudo teve como objetivo identificar perceções de jovens adultos portugueses sem filhos relativamente ao eventual projeto de parentalidade. Foram realizadas entrevistas a sete pessoas que se autoidentificaram como lésbicas, gays e bissexuais e que se voluntariaram para participar no estudo. As transcrições das entrevistas foram submetidas a Análise Interpretativa Fenomenológica. Os temas emergentes revelaram que o desejo e a intenção de ter filhos se associavam à ponderação de desafios ligados ao heterossexismo, mas também à reflexão sobre condições e recursos a mobilizar para o enfrentar. São apresentadas implicações com vista à otimização das experiências individuais a este nível.
Presentación del dossier. Políticas exteriores y de defensa sudamericanas: hacia un nuevo regionalismo
Authors: Busso Anabella , Alves-Soares Samuel
Published: September 2020

Presentación del dossier "Políticas exteriores y de defensa sudamericanas: hacia un nuevo regionalismo"
How Old is the Hebrew Bible? A Linguistic, Textual, and Historical Study, por Ronald Hendel y Jan Joosten. New Haven, CT: Yale University Press, 2018. Pp. xvi + 221.
Authors: Richter Eric E.
Published: September 2020

Ronald Hender y Jan Joosten han publicado esta obra que defiende vigorosamente la posibilidad de fechar la composición de los libros del AT a partir de las diferencias lingüísticas diacrónicas del idioma hebreo.
Correction to: Why public health matters today and tomorrow: the role of applied public health research
Authors: McLaren Lindsay , Braitstein Paula , Buckeridge David , Contandriopoulos Damien , Creatore Maria I. , Faulkner Guy , Hammond David , Hoffman Steven J. , Kestens Yan , Leatherdale Scott , McGavock Jonathan , Norman Wendy V. , Nykiforuk Candace , Ridde Valéry , Smylie Janet
Published: September 2020

The article “Why public health matters today and tomorrow: the role of applied public health research,” written by Lindsay McLaren et al., was originally published Online First without Open Access.
Норматив и стандарт: (пост)советская трансформация
Authors: Ерофеев Николай Андреевич , Сапунова Марина Викторовна
Published: September 2020

Вступительное слово от Н.А.Ерофеева и М.В.Сапуновой, редакторов-составителей номера.
The impact of leadership and organizational context on the acceptability of unethical HRM practices
Authors: Simões Eduardo , Duarte Patrícia , Nunes Patrícia
Published: September 2020

Recent research has found that human resource (HR) practitioners judge the acceptability of ethically questionable practices based on the importance their organization attributes to ethical infrastructure (e.g., codes of conduct) and corporate social responsibility practices. This study sought to evaluate the effects of ethical leadership and the aforementioned factors on other non-HR organizational actors. More specifically, this research examined how these individuals judge the acceptability of three ethically dubious HR management practices: discrimination, disregard for the individual, and favoring those in power. Results obtained from data collected through an online survey indicate that ethical leadership is negatively associated with the acceptability of all three practices. Individuals in organizations with a stronger ethical infrastructurealso find discrimination and disregard for the individual less acceptable. The same is true of participants in organizations perceived as more socially responsible regarding employees and economic aspects.
Trabalho em call-center: Comparação entre os serviços inbound e outbound
Authors: Gonçalves Susana , Silva Isabel Soares , Veloso Ana
Published: September 2020

O impacto do trabalho em call-center em várias dimensões físicas e psicológicas do indivíduo tem sido alvo de diversos estudos; no entanto, pouca investigação tem comparado os tipos de serviços neste contexto de trabalho. Assim, este estudo, além de fazer uma análise das características do trabalho, das principais fontes de stress e do compromisso com a organização neste tipo de contexto, comparou os serviços inbound e outbound em função de tais dimensões. No total, participaram 274 operadores de call-center, 191 do serviço inbound e 83 do serviço outbound. Na recolha de dados foi usado um protocolo de investigação constituído por diversas escalas, em formato papel e online. Verificou-se que participantes do grupo inbound percecionam uma maior variedade de competências no seu trabalho e níveis superiores de stress relacionados com problemas familiares do que os participantes do grupo outbound. Não foram encontradas diferenças significativas em relação ao compromisso com a organização.
Avaliação da saúde dos professores portugueses: O Questionário de Saúde Docente
Authors: Borralho Liberata , De Jesus Saúl Neves , Viseu João , Candeias Adelinda
Published: September 2020

Nas últimas décadas temos assistido a uma crescente deterioração da saúde docente, que afeta os professores e a escola enquanto organização. Este estudo pretendeu avaliar a saúde dos professores portugueses através do Questionário de Saúde Docente, numa amostra de 5009 professores. Os resultados das análises fatoriais suportam uma estrutura penta-fatorial (bem-estar profissional, esgotamento, distúrbios cognitivos, distúrbios musculosqueléticos, alterações da voz), com bons indicadores de qualidade do modelo com cinco fatores correlacionados (modelo 2). Os resultados indicaram que mais da metade dos professores apresenta problemas de saúde. Os do ensino público, 1.º ciclo, género feminino, com mais de 50 anos e 21 ou mais anos de serviço, são os que apresentam menor bem-estar e maior perda de saúde. A análise de clusters forneceu uma solução de três grupos: saúde alta, média e baixa. São discutidos os resultados e suas implicações individuais e organizacionais, bem como são fornecidas diretrizes para investigações futuras.
Atas do X Simpósio Nacional de Investigação em Psicologia, Universidade da Madeira, 2019
Authors: Rodrigues David L. , Pocinho Margarida , Lopes Diniz
Published: September 2020

As Atas do X SNIP representam a relevância deste Simpósio Nacional de Investigação em Psicologia na difusão do conhecimento produzido em Portugal nesta área científica. Estas Atas são publicadas, pela segunda vez, na revista PSICOLOGIA, o órgão de difusão científica da Associação Portuguesa de Psicologia. Dado que a revista se encontra indexada em diferentes bases de dados internacionais e nacionais, cremos que estes trabalhos poderão atingir uma comunidade de investigadores bastante alargada, permitindo que a investigação realizada em Portugal desperte o interesse de académicos e profissionais da psicologia em diferentes partes do mundo.