bluuebunny/crossref_metadata_2025 huggingface dataset:
Feasibility and Acceptability of a Culturally Tailored Website to Increase Fruit and Vegetable Intake and Physical Activity Levels in African American Mother-Child Dyads: Observational Study (Preprint)
Authors: Chung Alicia , Wallace Barbara , Stanton-Koko Monica , Seixas Azizi , Jean-Louis Girardin
Published: October 2018

BACKGROUND

African American youth (aged 8-14 years) do not adhere to national dietary and physical activity guidelines. Nonadherence to these recommendations contributes to disproportionate rates of obesity compared with their white counterparts. Culturally tailored electronic health (eHealth) solutions are needed to communicate nutrition and physical activity messages that resonate with this target population.

OBJECTIVE

This study aimed to identify the impact of exposure to a website hosting culturally tailored cartoons to inspire fruit and vegetable uptake and physical activity levels in African American mother-child dyads.

METHODS

Statistical analysis included paired sample t tests to evaluate knowledge gains, self-efficacy, and readiness to change. Adapted items from Prochaska’s Stages of Change toward the following 4 behaviors were assessed with pre- and posttest surveys: (1) fruit and vegetable selection on my plate, (2) meal preparation, (3) fruit and vegetable selection outside of home, and (4) physical activity. Open-ended comments on videos from mother-child dyads were used to determine user acceptance. Observations of repeated responses during content analysis informed coding and development of key themes.

RESULTS

A final sample size of 93 mother-child dyads completed the study. Mothers reported significant improvement from precontemplation or contemplation stages to preparation or action stages for (1) fruit and vegetable selection on her plate (P=.03), (2) meal preparation for her family (P=.01), (3) fruit and vegetable selection outside the home (P<.001), and (4) physical activity (P<.001). Significant improvements were found in knowledge, stage of change, and self-efficacy for the 4 target behaviors of interest (P<.001). Children’s open-ended commentary reported vicarious learning and positive character identification with brown-skinned cartoons exhibiting healthful food and exercise behaviors. Mothers commented on the lack of accessible produce in their neighborhoods not depicted in the cartoon videos.

CONCLUSIONS

Culturally adapted cartoons that incorporate tailored preferences by African American families, such as race or demography, may help increase adherence to target health behaviors when developing eHealth behavior solutions.
Model-Based Methods to Translate Adolescent Medicine Trials Network for HIV/AIDS Interventions Findings Into Policy Recommendations: Rationale and Protocol for a Modeling Core (ATN 161) (Preprint)
Authors: Neilan Anne M , Patel Kunjal , Agwu Allison L , Bassett Ingrid V , Amico K. Rivet , Crespi Catherine M , Gaur Aditya H , Horvath Keith J , Powers Kimberly A , Rendina H Jonathon , Hightow-Weidman Lisa B , Li Xiaoming , Naar Sylvie , Nachman Sharon , Parsons Jeffrey T , Simpson Kit N , Stanton Bonita F , Freedberg Kenneth A , Bangs Audrey C , Hudgens Michael G , Ciaranello Andrea L
Published: October 2018

BACKGROUND

The United States Centers for Disease Control and Prevention estimates that approximately 60,000 US youth are living with HIV. US youth living with HIV (YLWH) have poorer outcomes compared with adults, including lower rates of diagnosis, engagement, retention, and virologic suppression. With Adolescent Medicine Trials Network for HIV/AIDS Interventions (ATN) support, new trials of youth-centered interventions to improve retention in care and medication adherence among YLWH are underway.

OBJECTIVE

This study aimed to use a computer simulation model, the Cost-Effectiveness of Preventing AIDS Complications (CEPAC)-Adolescent Model, to evaluate selected ongoing and forthcoming ATN interventions to improve viral load suppression among YLWH and to define the benchmarks for uptake, effectiveness, durability of effect, and cost that will make these interventions clinically beneficial and cost-effective.

METHODS

This protocol, ATN 161, establishes the ATN Modeling Core. The Modeling Core leverages extensive data—already collected by successfully completed National Institutes of Health–supported studies—to develop novel approaches for modeling critical components of HIV disease and care in YLWH. As new data emerge from ongoing ATN trials during the award period about the effectiveness of novel interventions, the CEPAC-Adolescent simulation model will serve as a flexible tool to project their long-term clinical impact and cost-effectiveness. The Modeling Core will derive model input parameters and create a model structure that reflects key aspects of HIV acquisition, progression, and treatment in YLWH. The ATN Modeling Core Steering Committee, with guidance from ATN leadership and scientific experts, will select and prioritize specific model-based analyses as well as provide feedback on derivation of model input parameters and model assumptions. Project-specific teams will help frame research questions for model-based analyses as well as provide feedback regarding project-specific inputs, results, sensitivity analyses, and policy conclusions.

RESULTS

This project was funded as of September 2017.

CONCLUSIONS

The ATN Modeling Core will provide critical information to guide the scale-up of ATN interventions and the translation of ATN data into policy recommendations for YLWH in the United States.
Improvising Touch
Authors: Vincent Meelberg
Published: October 2018

Sound examples for Improvising Touch
Type I Hypersensitivity in an Asthmatic Child Allergic to Peanuts: Was Soy Lecithin to Blame?
Authors: Béliveau Solange , Gaudreault Pierre , Goulet Lise , Primeau Marie-Noëlle , Marcoux Danielle
Published: October 2018

Background:

Soy lecithin is widely used as an emulsifier, not only in topical skin care products but also in various drugs administered either topically, orally, or intravenously or by inhalation. Patients strongly allergic to soy and/or peanuts can develop an anaphylactic reaction when exposed to soy lecithin.

Method:

We report a 3-year-old asthmatic boy, allergic to peanuts, who was treated at the emergency department for an exacerbation of asthma following an upper respiratory tract infection. Within an hour after receiving the second of two inhalations of an ipratropium bromide (Atrovent) metered dose inhaler, he developed respiratory distress and generalized urticaria, an adverse event that regressed within 48 hours of withdrawal of the suspected drug. Soy lecithin, contained as an excipient in the metered dose inhaler, was strongly suspected of being responsible for this reaction.

Conclusion:

Drug products containing soy lecithin can cause severe allergic reactions in patients allergic to peanuts or soy. Physicians should be aware that adverse drug reactions can be due to both the active medical component and the excipient ingredients.
Becker Nevus on the Lower Limb: Case Report and Review of the Literature
Authors: Alhusayen Raed , Kanigsberg Nordau , Jackson Robert
Published: October 2018

Background:

Becker nevus is a hamartoma with brown hyperpigmentation and hypertrichosis that usually affects young males. It has a predilection for the upper half of the trunk and proximal upper extremity.

Objective:

This is a case report of a 38-year-old male with a Becker nevus without hypertrichosis on the lower limb and a review of the literature.

Results:

Including our case report, 12 cases of Becker nevus on the lower limb were identified in the English literature (8 males and 4 females). It has never been reported below the knee. In males, the lesion was not associated with other anomalies, and all but two showed hypertrichosis (six of eight). In 50% (two of four) of women, it was associated with localized lipoatrophy. In one woman, it presented without hypertrichosis.

Conclusion:

The presence of Becker nevi on the lower limb is unusual, and hypertrichosis is not always a feature. Larger studies are required to look into the true prevalence of this presentation and its prognostic value as a marker for other anomalies.
Skin-Related Quality of Life among Migrant Farmworkers
Authors: Quandt Sara A. , Schulz Mark R. , Vallejos Quirina M. , Feldman Steven R. , Preisser John S. , Arcury Thomas A.
Published: October 2018

Background:

Farmworkers in North America work in an environment likely to produce skin injuries and illnesses that affect quality of life (QOL).

Objective:

We identified the dimensions of skin-related QOL that were most impaired and examined predictors in a cohort of North Carolina farmworkers.

Methods:

We conducted a longitudinal survey of 304 Latino farmworkers across a work season (1,048 interviews). We assessed skin-related QOL using the Dermatology Life Quality Index.

Results:

Effects on QOL were reported in 38.7% of observations. The greatest impacts of skin impairments were seen in the Symptoms and Feelings and Work and School Subscales. In multivariate analysis, specific work tasks and high temperatures were associated with greater decrements in QOL.

Conclusions:

Skin disease among farmworkers is sufficiently severe to affect QOL. Future research should test the effectiveness of interventions on modifiable factors such as facilities for personal hygiene and field sanitation on skin-related QOL.
Violaceous Papules on the Palms and Soles
Authors: Cheung-Lee Melody J. , Rao Jaggi
Published: October 2018

Background:

Lichen planus (LP) is a condition with many clinical variants that can be quite varied in their presentation.

Objective:

We report a case of a 60-year-old woman who presented with a very unusual palmoplantar eruption characterized by violaceous pustule-like papules that was subsequently diagnosed as LP.

Methods:

The above case is reported, along with biopsy results. The patient was subsequently treated with a combination of topical corticosteroids and oral acitretin, and her clinical course was followed.

Results:

The eruption responded dramatically to our combination treatment and resolved by the 2-month follow-up.

Conclusion:

Palmoplantar LP is a rare variant of LP that bears little resemblance to its classic LP. This condition responds well to a combination of potent topical corticosteroids and oral acitretin.
Use of Anakinra (Kineret) in the Treatment of Familial Cold Autoinflammatory Syndrome with a 16-Month Follow-Up
Authors: Ross J. Barrie , Finlayson Laura A. , Klotz P. Jennifer , Langley Richard G. , Gaudet Roxanne , Thompson Kara , Churchman Sarah M. , McDermott Michael F. , Hawkins Philip N.
Published: October 2018

Background:

The susceptibility gene for familial cold autoinflammatory syndrome (FCAS) has been mapped to chromosome 1q44 and a point mutation determined to be present in all affected members of a large Canadian kindred. Anakinra (Kineret) is known to block IL-1 receptor and in the few patients with FCAS in whom it has been used, it has been shown to provide relief for this lifelong disability.

Objective:

To demonstrate the efficacy and safety of anakinra (Kineret) in FCAS.

Methods:

Eight affected family members aged 29 to 77 years received anakinra 100 mg subcutaneously daily for 4 weeks preceded and followed by a 2-week control period.

Results:

The treatment was rapidly effective paralleled by the immediate fall of the C-reactive protein and serum amyloid A protein. The only significant side effect was an injection-site reaction in 50%, which declined in the follow-up period. The effect was sustained in all who continued to use the treatment at 4 and 16 months of follow-up.

Conclusion:

This is the first treatment of FCAS that is completely effective while it is used.
Propranolol in the Treatment of Problematic Infantile Hemangioma: Review of 35 Consecutive Patients from a Vascular Anomalies Clinic
Authors: Bertrand Janie , Sammour Rita , Mccuaig Catherine , Dubois Josée , Hatami Afshin , Ondrejchak Sandra , Boutin Christine , Bortoluzzi Patricia , Laberge Louise C. , Powell Julie
Published: October 2018

Background:

Propranolol, a nonselective β-blocker, has been reported as efficient for controlling the growth of complicated infantile hemangiomas (IHs). No uniformly accepted protocol exists regarding the administration of oral propranolol for IH.

Objective:

We sought to share our experience using propranolol for problematic IH and to evaluate the efficacy of this treatment modality.

Methods:

A retrospective chart review analysis was performed for 35 consecutive children treated with propranolol as an oral solution on an outpatient basis in our dermatology/vascular anomalies clinic. A protocol was established with the help of our pediatric cardiologists, including pretreatment electrocardiography and echocardiography. Medical photographs taken after 2 months of treatment were rated by two independent evaluators.

Results:

We treated 31 girls and 4 boys with a median age of 3.5 months. Rapid improvement was reported in the first days of treatment in 34 patients. Mean improvement after 2 months was 61.5%. No serious adverse effects were reported.

Conclusion:

Propranolol was effective in controlling the proliferative phase of problematic IH. It was well tolerated in our study. Outpatient treatment is possible if parents follow strict guidelines. Propranolol should be a first-line treatment for problematic IH in carefully selected patients.
Is Necrolytic Migratory Erythema Due to Glucagonoma a Misnomer? A More Apt Name Might Be Mucosal and Intertriginous Erosive Dermatitis
Authors: Grewal Parbeer , Salopek Thomas G.
Published: October 2018

Background:

In dermatology, many conditions are given names that ultimately prove to be a misnomer (eg, mycosis fungoides, pyogenic granuloma). For most misnomers, continued use of the inappropriate word(s) rarely results in a delay in diagnosis and/or treatment. An argument can be made that the term necrolytic migratory erythema (NME) due to glucagonoma results in a delay in diagnosis, often with fatal consequences.

Objective:

We reviewed the literature of the past 30 years concerning the dermatologic and histologic findings of NME in association with glucagonoma. The most striking feature evident in nearly all reported cases is the presence of mucosal lesions and annular, eroded, eczematous patches and plaques of intertriginous areas.

Conclusion:

We propose the renaming of the eruption associated with glucagonoma to one that emphasizes its unique localization to the mucosa and intertriginous areas: mucosal and intertriginous erosive dermatitis. It is hoped that this will lead to a more timely recognition of the condition and a possible improvement in prognosis.
Physician Survey Regarding Patient Nonattendance at Follow-up Appointments at a University-Affiliated Medical Dermatology Clinic
Authors: Nasseri Eiman , Bertrand Janie , Brassard Danielle , Fortier-Riberdy Geneviève , Marcil Isabelle
Published: October 2018

Background:

Patient nonattendance is a frequent occurrence in dermatology clinics, and our responsibility regarding the follow-up of these patients remains nebulous.

Objective:

This study sought to evaluate the beliefs and practices of physicians at a university-affiliated medical dermatology clinic regarding patient nonattendance at follow-up appointments and to provide an algorithm to deal appropriately with absentee patients based on various Canadian medical association guidelines.

Methods:

A questionnaire was distributed to the 17 dermatologists practicing at the Centre Hospitalier de l'Université de Montréal medical dermatology clinic. We contacted provincial and national medical associations regarding directives for patient follow-up.

Results:

There is a lack of consensus among dermatologists at the Centre Hospitalier de l'Université de Montréal regarding responsibility toward patients who miss their follow-up appointments. However, the majority of survey respondents consider that patient follow-up must be adjusted on a case-by-case basis and that diagnoses at risk for high morbidity and mortality require particular attention, which is in line with various Canadian medical association guidelines.

Conclusion:

Dermatologists should have a structured approach to dealing with patients who miss their follow-up appointments to ensure the appropriate care of all patients.
Use of Pioglitazone in Patients with Lichen Planopilaris
Authors: Baibergenova Akerke , Walsh Scott
Published: October 2018

Background:

Recent basic science research has revealed a decreased tissue expression of peroxisome proliferator-activated receptor (PPAR) γ in lichen planopilaris (LPP). Therefore, thiazolidinediones, being PPARγ agonists, could be used to treat LPP.

Methods:

We followed 24 patients with LPP who were treated with oral pioglitazone hydrochloride. Improvement in LPP was defined as a decrease in or disappearance of symptoms and perifollicular erythema in the context of halted spread of old patches.

Results:

Twenty of 24 patients were females. The average age was 52.5 years, and ages ranged from 22 to 70 years. Five of 24 patients have achieved remission; improvement was noted in half of the patients; there was no change in 3 patients; and 4 patients discontinued treatment due to side effects. Side effects were mild and included left calf pain, lightheadedness and nausea, dizziness, and hives.

Conclusion:

Use of thiazolidinediones might be a new promising venue of LPP treatment.
Local Infiltrative Anesthetic Effect of Tramadol Compared to Lidocaine for Excision of Cutaneous Lesions: Pilot Randomized, Double-Blind Clinical Study
Authors: Kakagia Despoina , Vogiatzaki Theodosia , Eleftheriadis Savvas , Trypsiannis Gregory , Iatrou Christos
Published: October 2018

Background:

In this double-blind, randomized study, the efficacy of tramadol, an atypical opioid, was tested versus lidocaine in excision of cutaneous lesions of the face.

Methods:

Eighty-eight patients were randomly assigned to receive either 2 mg/kg tramadol 2% plus adrenaline 1:200,000 (group T, n = 46) or 3 mg/kg lidocaine 2% plus adrenaline 1:200,000 (group L, n = 42) for excision of cutaneous lesions. Pain at the injection site, 2 and 20 minutes postinjection and 3, 6, and 12 hours postoperatively, was monitored on a 0 to 10 numerical rating scale (NRS). Irritation at the injection point and the duration of postoperative analgesia were also recorded.

Results:

There were no significant differences in demographic data, topography, size of the lesions removed, and operative time between the two groups. A tendency toward lower injection NRS pain scores was observed in group L compared to group T (p = .064). No statistically significant differences between the two groups were found at 2 and 20 minutes postinjection (p = .741 and p = .142, respectively); however, pain scores were significantly higher in group L at 3, 6, and 12 hours postoperatively (all p < .001). Erythema at the injection site was observed in nine group T and two group L patients (p = .076). No postoperative analgesics were required in the tramadol group of patients, whereas acetaminophen with or without codeine was administered in all but five lidocaine group patients during the first 12 hours.

Conclusion:

Tramadol may be used as a reliable local anesthetic agent, providing longer postoperative analgesia compared to lidocaine; however, it bears a higher incidence of irritation at the injection site.
Outcomes of Wound Closure with the Reading Man Flap Technique
Authors: Wagner Justinus A. , Simon Jan C. , Wetzig Tino , Kendler Michael
Published: October 2018

Background:

In dermatologic surgery, numerous flap types have been described for wound closure after skin cancer surgery. The reading man flap was first published in 2008 for the closure of skin defects of the face, trunk, and extremities. Technically, this flap is based on an asymmetrical Z-plasty.

Objective:

To investigate the feasibility, clinical outcomes, and postoperative complications for wound closure with the reading man flap technique.

Methods:

We treated seven patients (facial and extremity defects) after microscopically controlled surgery using the reading man flap technique. The median defect size was 491.71 mm2. All of the patients were treated under tumescent local anesthesia.

Results:

A tension-free defect closure was created in all patients. One minor complication, a wound infection on one leg, was observed.

Conclusion:

The described technique is an easy and safe dermatologic surgery procedure that can be performed under local anesthesia.
Eruptive Squamous Cell Carcinomas after Vemurafenib Therapy
Authors: Mays Rana , Curry Jonathan , Kim Kevin , Tsai Kenneth , Arora Anita , Khan Farhan , Ramirez-Fort Marigdalia , Ciurea Ana
Published: October 2018

Background:

Vemurafenib is an oral BRAF inhibitor recently approved for the treatment of metastatic melanoma. Patients treated with this medication have been reported to have the occurrence of squamous cell carcinoma (SCC) and/or actinic keratosis (AK).

Objective:

We report the case of a patient treated with vemurafenib for papillary thyroid carcinoma who subsequently developed multiple SCCs and AK of the skin. The lesions were deemed related to the medication and treated with excision. In addition, subsequent development of SCCs and AK was successfully prevented with a combination of isotretinoin and 5-fluorouracil in this patient. We discuss postulated mechanisms for these findings, as well as potential preventive therapy with the aforementioned combination regimen in patients undergoing treatment with vemurafenib.
Acute Generalized Exanthematous Pustulosis Induced by Hydroxychloroquine: First Case Report in Canada and Review of the Literature
Authors: Bailey Kristy , Mckee Daniel , Wismer Judy , Shear Neil
Published: October 2018

Background:

Acute generalized exanthematous pustulosis (AGEP) is a rare drug eruption presenting with an acute, extensive formation of nonfollicular sterile pustules on an erythematous and edematous base. Typically, the rash is accompanied by fever and leukocytosis, with spontaneous resolution in < 15 days. The incidence of AGEP is estimated at one to five cases per million people per year. Only 18% of these are from nonantibiotics. Hydroxychloroquine (HCQ) is an antimalarial agent that is also used to treat various dermatologic and rheumatologic conditions.

Objective:

We report the first observation in Canada of a patient with AGEP induced by HCQ.

Methods and Results:

AGEP was diagnosed in a 48-year-old female who had been taking HCQ for 2 weeks and then developed a diffuse erythematous and edematous pustular eruption. Clinical and pathologic findings were consistent with a diagnosis of AGEP. The patient was treated with steroids and supportive measures. The rash resolved after 18 days and a complicated course in hospital.

Conclusion:

AGEP is a rare drug eruption, usually to antibiotics. We report the first case in Canada of AGEP as an adverse reaction to HCQ. Clinicians should keep in mind the possibility of this severe skin eruption.
The Children's Dermatology Life Quality Index (CDLQI): Linguistic and Cultural Validation in Serbian
Authors: Janković Slavenka , Vukićević Jelica , Djordjević Sanja , Janković Janko , Marinković Jelena , Erić Miloš
Published: October 2018

Background:

The Children's Dermatology Life Quality Index (CDLQI) evaluates the impact of skin diseases on the patient's quality of life.

Objective:

The purpose of the study was to translate and to validate the CDLQI into Serbian.

Methods:

The CDLQI was translated into Serbian following international recommendations for translation and cultural adaptation. The validation study was carried out on a large cohort of secondary schoolchildren who self-reported acne.

Results:

Translating the CDLQI consisted of forward translation, reconciliation, back translation, back-translation review, and cognitive debriefing. The good internal consistency of the scale was demonstrated with a Cronbach alpha coefficient of 0.87. A Spearman correlation coefficient of 0.66 between the CDLQI and the Cardiff Acne Disability Index (CADI) was deemed satisfactory to demonstrate concurrent validity.

Conclusion:

The translation, cross-cultural adaptation, and psychometric qualities of the CDLQI were satisfactory, enabling its application in clinical practice and future studies.
Pityriasis Rotunda Diagnosed in Canada: Case Presentation and Review of the Literature
Authors: Zur Rebecca L. , Shapero Jonathan , Shapero Harvey
Published: October 2018

Background:

Pityriasis rotunda is a rare cutaneous disorder characterized by scaly, circular, well-demarcated, hypo- or hyperpigmented, fine plaques over the trunk and extremities.

Objective:

We present a case of pityriasis rotunda in a 44-year-old African-Canadian woman who presented to a community dermatology practice in Toronto.

Results:

Pityriasis rotunda has been well described in Japan, Italy, and South Africa. It is extremely rare in North America, with nine reported cases to date, the majority of which were diagnosed in the United States.

Conclusion:

Pityriasis rotunda is a rare cutaneous disorder associated with systemic disease. To the best of our knowledge, this is the second report of pityriasis rotunda diagnosed in Canada.
Marjolin Ulcer: Clinical Experience with 34 Patients over 15 Years
Authors: Yesilada Aysin Karasoy , Sevim Kamuran Zeynep , Sucu Deniz Özgur , Akçal Arzu , Karşidaǧ Semra , Kilinc Leyla , Kizilkaya Hazim Orhan
Published: October 2018

Background:

Malignancies that arise from scars are referred to as Marjolin ulcers. The association between chronic ulcers and squamous cell carcinomas is well established. There are many case reports in the literature regarding Marjolin ulcer; however, randomized controlled clinical series that describe a thorough evaluation of these patients are rarely encountered.

Objective:

We present our clinic's 15 years of experience with 34 Marjolin ulcer patients and their treatment modalities.

Methods:

A retrospective analysis of 302 squamous cell carcinoma patients who were treated in the plastic surgery department between 1997 and 2011 was performed. Thirty-four (10.3%) histopathologically confirmed Marjolin ulcer patients were further analyzed.

Results:

Although burn scars represented 77% of the patients in the present study, unstable scars that formed following traffic accidents and fistula tracts are also among the commonly encountered etiologies. Based on our observations, squamous cell carcinoma, in addition to malignant melanoma and verrucous carcinoma, is frequently observed in cases of Marjolin ulcers.

Conclusion:

If the goal is to eradicate this clinical entity, all of the chronic ulcers that fail to heal require biopsies at regular intervals. Large excisional margins, lymphadenectomies in cases of palpable lymph nodes, and a well-defined oncology protocol are all essential in treating Marjolin ulcer.
Congenital Telangiectatic Atrophic Patch on a Healthy Child
Authors: Garcia-Romero Maria Teresa , Ching Joyce C.Y. , Ho Nhung
Published: October 2018

Background:

Rapidly involuting congenital hemangiomas (RICHs) are rare vascular tumors that have a proliferative phase in utero, present fully grown at birth, and have a fast involution phase after birth. Even rarer cases have completed involution in utero and present at birth as an atrophic plaque with redundant skin.

Case Report:

We present one case of a RICH that underwent involution in utero and revise the diagnostic and management implications.
Sarcoidosis Can Present with Necrotizing Granulomas Histologically: Two Cases of Ulcerated Sarcoidosis and Review of the Literature
Authors: Noiles Kristin , Beleznay Katie , Crawford Richard I. , Au Sheila
Published: October 2018

Background:

Sarcoidosis is a systemic inflammatory disorder with cutaneous involvement present in 25% of cases. The presence of naked granulomas histologically is the hallmark of sarcoidosis. The presence of necrotizing granulomas is highly suggestive of other granulomatous conditions and leads the clinician to pursue other diagnoses, such as infectious causes.

Objectives:

We describe two cases of sarcoidosis in which necrotizing granulomas were present on biopsy. Both patients had ulcerated cutaneous lesions of sarcoidosis. In one case, the presence of these atypical histologic features led to a delay in diagnosis of almost 10 years. We review the various histopathologic findings associated with cutaneous sarcoidosis and discuss a potential connection between ulcerated sarcoidosis and atypical histologic findings.

Conclusion:

When atypical histopathologic features are present, the differential diagnosis of sarcoidosis should not be excluded.
Analysis of the Prevalence of Allergic Contact Dermatitis to Sunscreen: A Cohort Study
Authors: Beleznay Katie , de Gannes Gillian , Kalia Sunil
Published: October 2018

Background:

As the use of sunscreens becomes more prevalent, reports of adverse effects to sunscreens have increased.

Objective:

To analyze a patch test database for the prevalence of allergic contact dermatitis (ACD) to sunscreen.

Methods:

The database was searched for positive patch test reactions to benzophenone-3. Charts were also reviewed for those who were further tested to the sunscreen series.

Results:

Twenty-three of the 1,527 patients seen were tested to the sunscreen series. Of these, only 4 patients had a positive reaction to a sunscreen chemical or to the product they were using. In addition, 8 of the 1,527 patients who had no specific history of sunscreen allergy reacted to benzophenone-3.

Conclusion:

ACD to sunscreen was found to be very uncommon (0.8%). Other final diagnoses included ACD to excipients such as fragrances or preservatives and suspected photosensitive disorders.
Erythema Annulare Centrifugum due to Pegylated Interferon-α-2a plus Ribavirin Combination Therapy in a Patient with Chronic Hepatitis C Virus Infection
Authors: Gönül Müzeyyen , Çakmak Seray Külcü , Özcan Nimet , Oǧuz Işil Deniz , Özhamam Esra
Published: October 2018

Background:

Pegylated interferon-α combined with ribavirin is the current standard treatment for chronic hepatitis C virus infection. During interferon and ribavirin therapy, both local and generalized mucocutaneous adverse reactions have been reported. Erythema annulare centrifugum induced by this therapy regimen has not been reported previously.

Case Report:

A 29-year-old woman was referred to our clinic for a 1-week history of slightly pruritic annular erythematous eruptions on the lower extremities and hands. The eruptions had first occured on the hands 3 to 4 days after pegylated interferon-α-2a plus ribavirin combination therapy for hepatitis C virus infection. Histopathologic examination supported the diagnosis of erythema annulare centrifugum. The lesions completely regressed within 2 weeks after the cessation of treatment but recurred on similar localizations within 24 hours with the same therapy. It was thought that erythema annulare centrifugum was induced by pegylated interferon-α-2a plus ribavirin combination therapy.

Conclusion:

Erythema annulare centrifugum is considered an inflammatory skin disease with unknown etiology. It is thought to represent a hypersensitivity reaction to some triggering factors, including infections, immunologic disorders, malign neoplasms, foods, pregnancy, and drugs. We report the first case of erythema annulare centrifigum induced by pegylated interferon-α-2a plus ribavirin combination therapy.
Kerion of the Vulva Caused by Trichophyton mentagrophytes
Authors: Bougrine Amina , Villeneuve-Tang Catherine , Bouffard Danielle , Rouleau Danielle , Chartier Suzanne
Published: October 2018

Background:

Deep dermatophytosis of genital skin is a rare clinical manifestation of infection by a common group of pathogens.

Objective:

We emphasize the importance of clinical suspicion and the use of accurate diagnostic methods in the evaluation of deep dermatophytosis.

Methods:

We report a single case of tinea pubis, kerion type, caused by Trichophyton mentagrophytes in an immunocompetent host.

Results:

A 54-year-old female presented with a suppurative infection of the vulva and pubis that was unresponsive to empirical antibiotic therapy. T. mentagrophytes was isolated. Oral itraconazole was initiated on the basis of clinical suspicion and continued for a total of 6 weeks.

Conclusion:

Accurate diagnosis and treatment of deep dermatophytosis of genital skin rests upon proper identification of the pathogen. Prompt initiation of treatment with an oral antifungal agent, such as itraconazole, should be undertaken in order to avoid irreversible scarring alopecia.
The concept of gene in the twenty-first century: What are the open avenues?
Authors: El-Hani Charbel N. , Meyer Diogo
Published: October 2018

ABSTRACTThe view of the gene as a structural and functional unit has been increasingly challenged by findings mostly resulting from eukaryote research. We can classify these challenges in three kinds: (i) one-to-many correspondences between DNA segments and RNAs/polypeptides (as, for instance, in alternative splicing); (ii) many-to-one correspondences between DNA segments and RNAs/polypeptides (as in genomic rearrangements, say, those involved in the generation of diversity in lymphocyte antigen receptors); (iii) lack of correspondence between DNA segments and RNAs/polypeptides (as, for example, in mRNA editing). However, even if a single definition of a gene may not be a realistic (or even helpful) goal, being able to have different definitions connected to each other –operationally and theoretically– is of central importance.KEYWORDSGENE CONCEPT, DEFINITION, DNARESUMENLa idea según la cual el gen es una unidad estructural y funcional se ha visto cada vez más cuestionada a causa de descubrimientos realizados en investigaciones con eucariotas. Podemos clasificar los desafíos planteados a dicha idea en tres tipos: (i) correspondencias uno-a-muchos entre segmentos de ADN y ARN/polipéptidos (como, por ejemplo, en el empalme alternativo); (ii) correspondencias muchos-a-uno entre segmentos de ADN y ARN/polipéptidos (como en las reorganizaciones genómicas, tales como las implicadas en la generación de diversidad en los receptores de antígenos de los linfocitos); (iii) falta de correspondencia entre segmentos del ADN y ARN/polipéptidos (como, por ejemplo, en la edición del ARNm). Sin embargo, incluso si, por estas razones, no sería realista (o incluso útil) buscar una definición única de gen, es de capital importancia que seamos capaces de formular diferentes definiciones conectadas entre sí teórica y operacionalmente.PALABRAS CLAVECONCEPTO DE GEN, DEFINICIÓN, ADN
Jerarquías, integración y complejidad en biología. Un posible marco para la evo-devo
Authors: Casanueva Mario , Folguera Guillermo , Peimbert Mariana
Published: October 2018

RESUMENHistóricamente, las jerarquías han servido para clasificar y organizar la vida. Actualmente, es claro que capturar conceptualmente la complejidad y diversidad de la vida, requiere más de una sola jerarquía. Aquí se abordan algunos de los principales retos que enfrentan las jerarquías al procurar aprehender la biodiversidad. Para resolverlos, se propone una red de jerarquías que sirven de descriptores de procesos con genidentidad y pluralismo ontológico, desde una perspectiva y nivel particulares. La red de jerarquías se concibe como un conjunto de ramas en crecimiento que pueden dividirse y unirse de múltiples maneras. Nuestra perspectiva resuelve varios de los problemas identificados e integra perspectivas multinivel justo lo que se requiere para construir del marco demandado por la evo-devo.PALABRAS CLAVEEVO-DEVO, DIVERSIDAD BIOLÓGICA, PLURALISMO ONTOLÓGICO, TIEMPO EN BIOLOGÍA, TEORÍAS MULTINIVELABSTRACTThroughout history hierarchies have been useful for categorizing and organizing life. It is clear that one hierarchy is not enough for the conceptualization of the complexity and diversity of life as we currently understand them. In this paper we address some of the key challenges associated hierarchies when apprehending biodiversity. Furthermore, we propose a network which consists of different hierarchies that serve as descriptors of processes with genidentity and ontological pluralism. Each hierarchy describes a process from a particular perspective and level. Thus, this network is conceived as growing branches that can divide and join multiple ways. Our approach solves several of the identified challenges and it becomes a way of integrating thoughts to allow the construction of a framework required by evo-devo.KEY WORDSEVO-DEVO, DIVERSITY OF LIFE, ONTOLOGICAL PLURALISM, TIME IN BIOLOGY, MULTI-LEVEL THEORIES
«Diseñar la biología»: Retos éticos,filosóficos y políticos de la biología sintética
Authors: Blasco Jordi M.
Published: October 2018

RESUMENEl intento de sentar las bases para convertir la biología en objeto de ingeniería es hoy una prioridad en la agenda de investigación científica. La bio-ingeniería permitiría fabricar y obtener lo que queramos a partir de la materia viviente, abriendo nuevos potenciales de expansión para la incipiente bioeconomía. El presente artículo aspira a discutir los retos éticos, filosóficos y políticos de la biología sintética, atendiendo tanto a su comprensión implícita de la vida como a sus posibles consecuencias para la relación entre ciencia, bioeconomía y sociedad.PALABRAS CLAVEÉTICA DE LA BIOLOGÍA SINTÉTICA; BIOINGENIERÍA; VIDA; TECNO-CIENCIA Y SOCIEDADABSTRACTThe attempt to render biology a matter of engineering has been settled as one of the priorities in the scientific research agenda. Bio-engineering is supposed to allow us to manufacture and obtain anything we wish from living material, opening new expansion potentials for the emerging bioeconomy. This papers aims at discussing the ethical, philosophical and political challenges of synthetic biology, focusing both on its implicit understanding of the living as well as on its possible consequences for the relations between science, bioeconomy and society.KEYWORDSETHICS OF SYNTHETIC BIOLOGY; BIO-ENGINEERING; LIFE; TECHNO-SCIENCE AND SOCIETY
El enfoque jerárquico en el núcleo de los planteamientos organicistas y sistémicos en biología
Authors: Umerez Jon
Published: October 2018

RESUMENSi los elementos conceptuales que caracterizan el organicismo del siglo XX son la centralidad del organismo, la perspectiva sistémica y el pensamiento jerárquico en términos de niveles de organización, planteo que el enfoque jerárquico es la «marca» de una perspectiva propia o genuinamente sistémica. De forma complementaria, defiendo que la ausencia de un enfoque genuinamente jerárquico en algunas propuestas actuales, por ejemplo, en el campo de la emergente biología de sistemas, es indicativo del diferente origen y ambición de tales planteamientos. Como ilustración específica de este planteamiento presento la larga trayectoria del trabajo experimental y teórico de Paul A. Weiss.PALABRAS CLAVEBIOLOGÍA SISTÉMICA, JERARQUÍA, ORGANICISMO, PAUL A. WEISSABSTRACTIf the conceptual traits that characterize XXth century organicism are centrality of the organism, systemic perspective, and hierarchical thinking in terms of levels of organization, I maintain that hierarchical thinking is the «mark» of a properly or genuinely systemic perspective. Complementarily, I claim that the absence of a genuinely hierarchical approach in some current proposals as, for instance, within the emerging area of systems biology reveals the diverse origin and ambition of those positions. As a specific example I present the long trajectory of experimental and theoretical work of Paul A. Weiss.KEYWORDSSYSTEMS BIOLOGY, HIERARCHY, ORGANICISM, PAUL A. WEISS
Presentación
Authors: . Los editores
Published: October 2018

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Nuestra época en clave estética: estetización generalizada y nuevas artes
Authors: Cabot Mateu
Published: October 2018

Nuestro mundo, considerado desde la estética filosófica, puede caracterizarse con las categorías «estetización generalizada» y «nuevas tecnologías». Dos categorías que permiten profundizar en la comprensión de fenómenos de nuestra cultura actual. Este trabajo pretende ser una contribución a la construcción teórica de dichas categorías. Procederemos, primero, a analizar cada una de las dos categorías con la intención de aclarar su significado y la red conceptual en que están entretejidas, para después valorar algunos de los cambios conceptuales que de este análisis surgen inmediatamente.
La estética invisible del arte popular
Authors: Fernández Rosa
Published: October 2018

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Negatividad, utopía y metasonidos: modelos musicales para la filosofía de Adorno a Lachenmann
Authors: Notario Antonio
Published: October 2018

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La calidad de la democracia: presupuestos e indicios
Authors: Vargas-Machuca Ramón
Published: October 2018

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Educación y democracia en el liberalismo radical. El papel de las instituciones educativas
Authors: Torres Rosa M.
Published: October 2018

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La adquisición de representaciones mentales en el niño: resultados de un estudio de caso
Authors: Moreno-Torres Ignacio , Torres Santiago , Santana Rafael
Published: October 2018

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En el mundo de Truman. Génesis del estado de hiperrealidad.
Authors: Puelles Romero Luis
Published: October 2018

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¿Protegernos de la injusticia? Filosofía y retórica en la búsqueda platónica de una nueva paideia
Authors: Panea Márquez José Manuel
Published: October 2018

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Hacia una teoría de la educación para una ciudadanía democrática
Authors: Mougan Juan C.
Published: October 2018

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Ética ambiental, sociedad civil
Authors: López de la Vieja M. Teresa
Published: October 2018

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Modelos de razonamiento abductivo
Authors: Nepomuceno Fernández Ángel
Published: October 2018

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Metafísica y antropología: La noción moderna de sujeto
Authors: García González Juan A.
Published: October 2018

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El espíritu que niega siempre: una disidencia originaria
Authors: Grimaldi Nicolás
Published: October 2018

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¿Advertencia, o suposición del ser? (Sobre los métodos de la metafísica)
Authors: Padial Benticuaga Juan J.
Published: October 2018

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Introducción
Authors: Martínez-Freire Pascual F.
Published: October 2018

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Incorporización y la filosofía de la mente
Authors: Clark Andy
Published: October 2018

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Intención conjunta y colectiva
Authors: Tuomela Raimo
Published: October 2018

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El problema del mundo externo y el problema de la experiencia subjetiva. Algunas estrategias para llenar dos vacíos
Authors: Liz Manuel
Published: October 2018

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¿Puede la neurobiología enseñarnos algo sobre la conciencia?
Authors: Churchland Patricia S.
Published: October 2018

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Conciencia, lógica e inteligencia artificial
Authors: Burrieza Muñiz Alfredo
Published: October 2018

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Ciudadanía: Individuo y comunidad (Una aproximación desde la ética pública)
Authors: Muguerza Javier
Published: October 2018

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Individuo, comunidad, ciudadanía
Authors: Domènech Antoni
Published: October 2018

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El coste de la igualdad: Una reflexión sobre la cuestión multicultural
Authors: Rosales José M.
Published: October 2018

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Por un modelo democrático liberal-republicano
Authors: Rubio Carracedo José
Published: October 2018

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Sobre la naturaleza de los retos y desafíos y su inmerecido prestigio en la filosofía moral
Authors: Valdecantos Antonio
Published: October 2018

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El columpio de los dioses: hacia una estética comparada del juego
Authors: Fernández Gómez Rosa
Published: October 2018

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Walter Benjamin: Mito y escritura
Authors: Jarauta Francisco
Published: October 2018

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Humanismo fantástico. La conjunción hermenéutica de ética y estética en la obra de Fray Luis de León
Authors: Rodríguez Arnáiz Graciano G.
Published: October 2018

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Gadamer y la legitimación de los prejuicios en la filosofía hermenéutica
Authors: Parmeggiani Marco
Published: October 2018

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Defendiendo la Ciencia, dentro de la razón
Authors: Haack Susan
Published: October 2018

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Naturalismo biológico
Authors: Castrodeza Carlos
Published: October 2018

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Factores contextuales, tecnología y valores: ¿desde la periferia?
Authors: Pérez Sedeño Eulalia
Published: October 2018

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Las modalidades de la complejidad
Authors: Rescher Nicholas
Published: October 2018

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Tres momentos para la filosofía de la lógica
Authors: Díaz Estévez Emilio
Published: October 2018

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Balance de la filosofía de la matemática en el siglo XX
Authors: Caba Antonio
Published: October 2018

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Entre Bacon y Deleuze. La lógica de la sensación
Authors: Puelles Romero Luis
Published: October 2018

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Relación de las fuentes de la estética británica del siglo XVIII
Authors: Arregui Jorge V. , Arnau Pablo
Published: October 2018

Informe bibliográfico
Nietzsche: A su pesar, solidaridad y tolerancia
Authors: García Martín Gabriel
Published: October 2018

RESUMENAdoración de mi peculiaridad. Mirada rápida y efímera a las alusiones de lo ajeno. Lo abstracto que es <> no ha de asfixiar mi indiferencia. ¡No es de recibo aquello que no se decante en lo mío!. Por lo demás, los otros son muchos y demasiados, turba o grey, producto en gran parte del desecho que la evolución ha ido dejando atrás.A pesar de Nietzsche, caminar hacia la suficiencia, sin que ellos sean de los míos y yo sea de lo suyos, es un viaje imposible.Para hacer la verdad (incluso mi verdad) y hacer la libertad (incluso mi libertad), no se puede viajar solo.ABSTRACTAdoration of my peculiarity. A fast and ephemeral look to another's allusions. The abstract thing that is <> doesn't have to aphyxiate my distiction. It is not allow anything which doesn't cry up of on my own!. About the rest, the others are many and too many, are multitude of flock, most of them coming from the excesses that the evolution has been leaving behaind.Althought Nietzsche, walk to the self-sufficiency, besides the would be one of mine and I would be one of them, it's an imposible trip.To make the truth (herewith my truth) and to make the freedom (herewith my freedom), you cannot travel alone.
Subjetividad y separación. La crítica del joven Hegel a la separación de facultades y a la soledad ontológica.
Authors: Padial Juan J.
Published: October 2018

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La unidad en Hegel
Authors: Polo Leonardo
Published: October 2018

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Razón y locura en la antropología de Hegel
Authors: Brauer Daniel
Published: October 2018

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La experiencia de la autoconciencia en Hegel
Authors: Pérez Castro Daniel
Published: October 2018

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Die Überwindung verstandesmäßiger Freiheitskonzeptionen in Hegels „Herrschaft und Knechtschaft“
Authors: Ostritsch Sebastian
Published: October 2018

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‘Acting On’ Instead of ‘Stepping Back’: Hegel’s Conception of the Relation between Motivations and the Free Will
Authors: Yeomans Christopher
Published: October 2018

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LIBROS RECIBIDOS 305
Authors: . .
Published: October 2018

Libros Recibidos
Senilia Una selección de fragmentos póstumos de Arthur Schopenhauer
Authors: Mateu Alonso Juan D.
Published: October 2018

Introducción, traducción y notas de JUAN DAVID MATEU ALONSO
En la cuenta del tiempo. ¿Qué le debe Gadamer a Husserl?
Authors: Díez Fischer Francisco
Published: October 2018

ResumenEl programa del siguiente estudio es esclarecer la eficacia histórica que la fenomenología de la conciencia del tiempo de Husserl tiene sobre la hermenéutica filosófica de Hans-Georg Gadamer; herencia que Gadamer mismo reconoce cuando afirma «que una clara línea conduce desde el concepto de síntesis pasiva y la teoría de la intencionalidad anónima a la experiencia hermenéutica […]».1Palabras claveFenomenología, hermenéutica, conciencia, tiempo.AbstractThe plan of this study is to clarify the historical efficacy of Husserl’s phenomenology of time consciousness in the philosophical hermeneutics of Hans-Georg Gadamer. Gadamer himself accepts this legacy when he says that «a clear line leads from the concept of passive synthesis and the theory of anonymous intentionality to the hermeneutic experience […]».KeywordsPhenomenology, hermeneutic, conscience, time.