bluuebunny/crossref_metadata_2025 huggingface dataset:
Don’t Drop the Ball: A Comparison of Throwing Performance Between VR and Real Life
Authors: Kelling Samantha , Kelling Nicholas
Published: December 2023

A two-experiment study assessed throwing performance in VR and real life. The first experiment was a direct comparison of a carnival type throwing game in which participants attempted to throw 20 balls into a bucket from distances of 5 and 10 ft. Fifteen participants completed the task in both real life and in an identical VR environment. In the second experiment, the same task was repeated at the 5ft distance only with the addition of a randomized order of three different VR controllers and the real-life condition. Results from both experiments indicate substantial differences between real life and VR performance along with differences between controllers. Significant VR research has stressed enhancing visual quality to better replicate real life. However, the focus needs to shift to examine creating accurate psychomotor interactions to achieve more accurate performance and ultimately training success.
The Cultural Ecological Adaptation and Contemporary Development of Folk Sport: A Systematic Investigation Based on the Harvest Festival (Onam) Custom of Snake Boat Race (Vallam Kali) at Aranmula Village in Southern India
Authors: Halder Asim Kumar , Guohua Zheng
Published: December 2023

The Aranmula Vallam Kali, or Aranmula Snake Boat Race, is the most ancient folk cultural sport of India. It is well known for its unique history and culture. Over the years, due to the social, economic and political alteration and the influence of Western culture and westernisation, this oldest and richest folk sport culture has undergone a lot of transformation. India has vast diverse cultural traditions, traditional expressions and tangible and intangible cultural heritages. It’s time to think about the protection and preservation of our rich, diverse and unique cultural heritage. This article, through field investigation and document analysis method, focuses on cultural ecological adaptation and transformation of the Snake Boat Race from its origin to the contemporary time. The study explores an ecological response strategy from the micro, meso and macro levels, which reshape the value and cultural identity of the Snake Boat Race, improve its existing conditions through system construction and promote the protection and preservation of inheritance folk sport culture. In order to combine material, spiritual and cultural lines, the study also explores a ‘trinity protection and development model’ of linear cultural heritage of the ancient Pampa River.
Development of an electronic medical records project for Al-Razi hospital in Palestine
Authors: Neirat Doaa , Batran Ahmad , Ayed Ahmad
Published: December 2023

Background:

Electronic medical records (EMR) are considered an important aspect to improve medical services provided to patients. The purpose of this study was to assess the development of an Electronic Medical Records Project for Al-Razi hospital in Palestine.

Design and Methods:

The study was mixed method, qualitative and quantitative. The use of a questionnaire for the staff in the Al-Razi hospital and seven administrators’ participants were meat as focus group.

Results:

Approximately 136 participants in the study. The study findings reported that employees perceived the use of EMRs to have several benefits. The most common benefits include promoting patient safety culture and drug error reduction. In addition, the study findings reported that employees perceived the use of EMRs to have several challenges. The most common challenges include lack of knowledge and skill, insufficient time to use EMR, and limited of computers.

Conclusions:

Health informatics brings various benefits to the healthcare system. Some participants believed that the EMR system would improve patient care and it will improve patient satisfaction.
Overlapping Stevens-Johnson Syndrome and DRESS Syndrome Caused by Phenobarbital: A Vietnamese Case Report
Authors: Van Nguyen Khiem , Van Vu Quang , Tran Mai Hoang , Nguyen Huy Quoc , Le Chi Quynh , Dang Bang Cam Thi , Chu Hieu Chi , Van Nguyen Dinh
Published: December 2023

Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) Syndrome and Stevens-Johnson Syndrome (SJS) are severe cutaneous adverse reactions to drugs. Those reactions which are rare in children can be especially severe and challenging to diagnose and manage. Herein we present a 59-month-old male who presented with a rash, fever, and multiple organ dysfunction initiation of Phenobarbital for epilepsy. Diagnosis of ovelaping SJS and DRESS syndrome had been made based on clinical manifestations accompanied with skin biopsy according to RegisSCAR diagnostic criteria. A therapy with intravenous immune globulin (IVIG), corticosteroids and supportive care was given successfully for the patient. This case underscored the significance of promptly and effectively recognizing and managing these intricate reactions.
A comprehensive study of spray coating technique parameters and chemical postdeposition treatments for transparent conducting SWCNT thin films
Authors: Akyuz Serra Melek , Kalkan Burat Ayfer , Özkan Zayim Esra , Karatepe Nilgün
Published: December 2023

The demands for transparent conducting films (TCFs) are continuously increasing and the future of this industry is going toward large scale, cheap and mechanically stable electronics. This study shows a simple way to fabricate low-cost transparent conductive single-walled carbon nanotube (SWCNT) thin films by spray coating. The work employed here demonstrates that it is possible to fabricate highly efficient SWCNT TCFs without the use of expensive ultrasonic spray coating equipment. Highly conductive TCFs were prepared by dispersing SWCNTs in an N-Methyl-2-pyrrolidone (NMP) solution. The spray coated TCF properties were studied by the effect of spray gun carrier gas pressure, concentration, and volume sprayed onto the substrates. The prepared thin films were subjected to post treatments with nitric acid (HNO3) using different treatment methods and times in order to improve the electrical conductivity. To further investigate the effect of p-doping in SWCNT thin films, HNO3 treatments were combined with thionyl chloride (SOCl2). The experimental results indicated that spray coating is an effective method to obtain highly conductive films without any chemical treatment, resulting in 273 Ω/sq sheet resistance, at 84% in the visible range. Additionally, the optimized films treated with both HNO3 and HNO3/SOCl2 showed great improvements at 83%–85% in the visible range and in sheet resistances followed by 98 and 103 Ω/sq with very good FOM values (1.6 × 10−3 and 2 × 10−3, respectively).
Expanding Shared Reading: Integrating Expansive Literacy and Translanguaging Strategies to Support Multilingual Learners Who Communicate Using AAC
Authors: Wilhelm Alison M. , McGraw Melissa L.
Published: December 2023

Multilingual learners (MLs) who communicate via alternative and augmentative communication (AAC) experience many barriers to accessing inclusive literacy instruction with same-age and multilingual peers. Educators can support MLs who use AAC by designing shared reading instruction that incorporates expansive literacy and translanguaging strategies. After reading this article, three key takeaways for educators of ML who use AAC are: (a) expansive literacy learning is a socio-cultural practice that is guided by communication and connection, (b) inclusive shared reading instruction develops language and literacy skills, and (c) research-based strategies like dialogic reading, teaching vocabulary through text, and discussion-oriented comprehension instruction with peers can be adapted to support linguistically and expressively diverse learners. Practitioners can plan inclusive shared reading instruction by using these expansive literacy approaches and research-based strategies to support ML who communicate using AAC.
Systematic evaluation of donor-KIR/recipient-HLA interactions in HLA-matched hematopoietic cell transplantation for AML
Authors: Fein Joshua A. , Shouval Roni , Krieger Elizabeth , Spellman Stephen R. , Wang Tao , Baldauf Henning , Fleischhauer Katharina , Kröger Nicolaus , Horowitz Mary , Maiers Martin , Miller Jeffrey S , Mohty Mohamad , Nagler Arnon , Weisdorf Daniel , Malmberg Karl-Johan , Toor Amir A. , Schetelig Johannes , Romee Rizwan , Koreth John
Published: December 2023

In acute myeloid leukemia (AML), donor natural killer cell killer immunoglobulin–like receptors (KIR) and recipient HLA interactions may contribute to the graft-versus-leukemia effect of allogeneic hematopoietic cell transplantation (HCT). Analyses of individual KIR/HLA interactions, however, have yielded conflicting findings, and their importance in the HLA-matched unrelated donor (MUD) setting remains controversial. We systematically studied outcomes of individual donor-KIR/recipient-HLA interactions for HCT outcomes and empirically evaluated prevalent KIR genotypes for clinical benefit. Adult patients with AML (n = 2025) who received HCT with MUD grafts in complete remission reported to the Center for International Blood and Marrow Transplantation were evaluated. Only the donor-2DL2+/recipient-HLA-C1+ pair was associated with reduced relapse (hazard ratio [HR], 0.79; 95% confidence interval [CI], 0.67-0.93; P = .006) compared with donor-2DL2–/recipient-HLA-C1+ pair. However, no association was found when comparing HLA-C groups among KIR-2DL2+–graft recipients. We identified 9 prevalent donor KIR genotypes in our cohort and screened them for association with relapse risk. Genotype 5 (G5) in all recipients and G3 in Bw4+ recipients were associated with decreased relapse risk (HR, 0.52; 95% CI, 0.35-0.78; P = .002; and HR, 0.32; 95% CI, 0.14-0.72; P = .006; respectively) and G2 (HR 1.63, 95% CI, 1.15-2.29; P = .005) with increased relapse risk in C1-homozygous recipients, compared with other patients with the same ligand. However, we could not validate these findings in an external data set of 796 AML transplants from the German transplantation registry. Neither a systematic evaluation of known HLA-KIR interactions nor an empiric assessment of prevalent KIR genotypes demonstrated clinically actionable associations; therefore, these data do not support these KIR-driven strategies for MUD selection in AML.
Early predictive factors of failure in autologous CAR T-cell manufacturing and/or efficacy in hematologic malignancies
Authors: Baguet Clémentine , Larghero Jérôme , Mebarki Miryam
Published: December 2023

Chimeric antigen receptor (CAR) T-cell therapies have shown significant benefits in the treatment of hematologic malignancies, such as B-cell acute lymphoblastic leukemia (B-ALL) and B-cell lymphoma. Despite the therapeutic advances offered by these innovative treatments, failures are still observed in 15% to 40% of patients with B-ALL and >50% of patients with B-cell lymphoma. Several hypotheses have emerged including CD19-negative or -positive relapses, low CAR T-cell activation and/or expansion in vivo, or T-cell exhaustion. To date, in the European Union, CAR T cells granted with marketing authorization are autologous and thus associated with a strong heterogeneity between products. Indeed, the manufacturing of a single batch requires cellular starting material collection by apheresis for each patient, with variable cellular composition, and then challenging pharmaceutical companies to standardize as much as possible the production process. In addition, these cost and time-consuming therapies are associated with a risk of manufacturing failure reaching 25%. Thus, there is a growing need to identify early risk factors of unsuccessful production and/or therapeutic escape. Quality of the apheresis product, pathology progression, as well as previous treatments have been reported as predictive factors of the variability in clinical response. The aim of this review is to report and discuss predictive factors that could help to anticipate the manufacturing success and clinical response.
Overdeepenings in the Swiss plateau: U-shaped geometries underlain by inner gorges
Authors: Bandou Dimitri , Schlunegger Fritz , Kissling Edi , Marti Urs , Reber Regina , Pfander Jonathan
Published: December 2023

We investigated the mechanisms leading to the formation of tunnel valleys in the Swiss foreland near Bern. We proceeded through producing 3D maps of the bedrock topography based on drillhole information and a new gravimetric survey combined with modelling. In this context, the combination of information about the densities of the sedimentary fill and of the bedrock, together with published borehole data and the results of gravity surveys along 11 profiles across the valleys, served as input for the application of our 3D gravity modelling software referred to as PRISMA. This ultimately allowed us to model the gravity effect of the Quaternary fill of the overdeepenings and to produce cross-sectional geometries of these troughs. The results show that 2–3 km upstream of the city of Bern, the overdeepenings are approximately 3 km wide. They are characterized by steep to oversteepened lateral flanks and a wide flat base, which we consider as a U-shaped cross-sectional geometry. There, the maximum residual gravity anomaly ranges between − 3 to − 4 mGal for the Aare valley, which is the main overdeepening of the region. Modelling shows that this corresponds to a depression, which reaches a depth of c. 300 m a.s.l. Farther downstream approaching Bern, the erosional trough narrows by c. 1 km, and the base gets shallower by c. 100 m as revealed by drillings. This is supported by the results of our gravity surveys, which disclose a lower maximum gravity effect of c. − 0.8 to − 1.3 mGal. Interestingly, in the Bern city area, these shallow troughs with maximum gravity anomalies ranging from − 1.4 to − 1.8 mGal are underlain by one or multiple inner gorges, which are at least 100 m deep (based on drilling information) and only a few tens of meters wide (disclosed by gravity modelling). At the downstream end of the Bern area, we observe that the trough widens from 2 km at the northern border of Bern to c. 4 km approximately 2 km farther downstream, while the bottom still reaches c. 300 to 200 m a.s.l. Our gravity survey implies that this change is associated with an increase in the maximum residual anomaly, reaching values of − 2.5 mGal. Interestingly, the overdeepening’s cross-sectional geometry in this area has steeply dipping flanks converging to a narrow base, which we consider as V-shaped. We attribute this shape to erosion by water either underneath or at the snout of a glacier, forming a gorge. This narrow bedrock depression was subsequently widened by glacial carving. In this context, strong glacial erosion upstream of the Bern area appears to have overprinted these traces. In contrast, beneath the city of Bern and farther downstream these V-shaped features have been preserved. Available chronological data suggest that the formation of this gorge occurred prior to MIS 8 and possibly during the aftermath of one of the largest glaciations when large fluxes of meltwater resulted in the fluvial carving into the bedrock.
Construction of a strawberry breeding core collection to capture and exploit genetic variation
Authors: Koorevaar T. , Willemsen J. H. , Visser R. G. F. , Arens P. , Maliepaard C.
Published: December 2023

Background

Genetic diversity is crucial for the success of plant breeding programs and core collections are important resources to capture this diversity. Many core collections have already been constructed by gene banks, whose main goal is to obtain a panel of a limited number of genotypes to simplify management practices and to improve shareability while retaining as much diversity as possible. However, as gene banks have a different composition and goal than plant breeding programs, constructing a core collection for a plant breeding program should consider different aspects.

Results

In this study, we present a novel approach for constructing a core collection by integrating both genomic and pedigree information to maximize the representation of the breeding germplasm in a minimum subset of genotypes while accounting for future genetic variation within a strawberry breeding program. Our stepwise approach starts with selecting the most important crossing parents of advanced selections and genotypes included for specific traits, to represent also future genetic variation. We then use pedigree-genomic-based relationship coefficients combined with the ‘accession to nearest entry’ criterion to complement the core collection and maximize its representativeness of the current breeding program. Combined pedigree-genomic-based relationship coefficients allow for accurate relationship estimation without the need to genotype every individual in the breeding program.

Conclusions

This stepwise construction of a core collection in a strawberry breeding program can be applied in other plant breeding programs to construct core collections for various purposes.
Examining the effectiveness of home-based cardiac rehabilitation programs for heart failure patients with reduced ejection fraction: a critical review
Authors: Darvishzadehdaledari Shahram , Harrison Alexander , Gholami Fatemeh , Azadnia Arian
Published: December 2023

Background

Heart failure (HF) is the most common cardiovascular reason for hospital admission, particularly among patients older than 60 years old. Heart failure with reduced ejection fraction (HFrEF) comprises approximately 50% of all heart failure cases. Home-based cardiac rehabilitation (HBCR) is an alternative option to enhance the participation rate in cardiac rehabilitation (CR) interventions for patients who are not able to attend center-based cardiac rehabilitation (CBCR). The purpose of this review is to clarify the extent to which present studies of HBCR align with the core components defined by both the European Society of Cardiology (ESC) and the British Association for Cardiac Prevention and Rehabilitation (BACPR).

Methods

A critical review was conducted through four databases, MEDLINE, Embase, Cochrane Central Register of Controlled Trials, and Cochrane Database of Systematic Reviews, to identify randomized controlled trials up until June 2022. We scrutinized the commonalities between BACPR and ESC and developed a list of standards. The risk of bias was assessed using the RoB 2 tool.

Results

Among the 87 papers selected for full-text screening, 11 studies met the inclusion criteria. Six papers possessed a high proportion of fidelity to essential standards, four studies had a medium alliance, and one intervention had a low level of alliance.

Conclusion

Overall, the majority of included studies had medium to high alignment with standards and core components. However, a need for more attention to long-term strategy as an important standard is revealed. Rapid identification and initial assessment are the most met standards; however, lifestyle risk factor management and long-term outcomes were recognized as the least met standards.
Changes in glutamic oxaloacetic transaminase 2 during rat physiological and pathological cardiomyocyte hypertrophy
Authors: Liu Xin , Li Xiaolu , Zhou Haotan
Published: December 2023

Background

Physiological and pathological cardiomyocyte hypertrophy are important pathophysiological processes of adult congenital heart disease-associated ventricular hypertrophy. Glutamic oxaloacetic transaminase (GOT) is a vital marker of myocardial injury. This study aimed to investigate the changes in GOT levels during physiological and pathological cardiomyocyte hypertrophy in rats.

Methods

RNA-seq analysis and colorimetric methods were used to evaluate the changes in GOT mRNA and activity, respectively. GOT2 protein expression was detected by western blotting and immunofluorescence. Hematoxylin-eosin and wheat germ agglutinin methods were used to observe changes in rat cardiomyocyte morphology.

Results

In juvenile rat hearts, GOT mRNA expression and activity, and GOT2 protein level increased with age-related physiological cardiomyocyte hypertrophy; however, GOT2 protein level was reduced in hypoxia-induced pathological cardiomyocyte hypertrophy.

Conclusions

GOT2 may regulate physiological and pathological myocardial hypertrophy in rats. We speculated that the low GOT2 level contributed to the rapid occurrence of pathological cardiomyocyte hypertrophy, causing strong plasticity of right ventricular cardiomyocytes in the early postnatal period and heart failure in adulthood.
Risk assessment scales to predict risk of lower extremity deep vein thrombosis among multiple trauma patients: a prospective cohort study
Authors: Chen Huijuan , Sun Libing , Kong Xiangyan
Published: December 2023

Background

Deep vein thrombosis (DVT) is a common complication in orthopedic patients. Previous studies have focused on major orthopedic surgery.There are few studies with multiple trauma. We aimed to describe the prevalence of DVT and compare the predictive power of the different risk assessment scales in patients with multiple trauma.

Methods

This prospective cohort study involved multiple trauma patients admitted to our hospital between October 2021 and December 2022. Data were prospectively collected for thrombotic risk assessments using the Risk Assessment Profile for thromboembolism(RAPT), the DVT risk assessment score (DRAS), and the Trauma Embolic Scoring System (TESS), respectively. The receiver operation characteristic (ROC) curve and the area under the curve (AUC) were evaluated to compare the predictive power. The whole leg duplex ultrasound of both lower extremities Doppler ultrasound was used to determine DVT incidence.

Results

A total of 210 patients were included, and the incidence of DVT was 26.19%. Distal DVT accounted for 87.27%; postoperative DVT, 72.73%; and bilateral lower extremity thrombosis, 30.91%. There were significant differences in age, education degree, pelvic fracture, surgery, ISS, D-dimer level, length of hospital stay and ICU stay between the thrombosis group and the non-thrombosis group. The AUCs for RAPT, DRAS, and TESS were 0.737, 0.710, and 0.683, respectively. There were no significant differences between the three ROC curves.

Conclusions

The incidence of DVT was relatively high during hospitalization. We prospectively validated the tests to predict risk of DVT among patients with multiple trauma to help trauma surgeons in the clinical administration of DVT prophylaxis.
Acute care models for older people living with frailty: a systematic review and taxonomy
Authors: Knight Thomas , Kamwa Vicky , Atkin Catherine , Green Catherine , Ragunathan Janahan , Lasserson Daniel , Sapey Elizabeth
Published: December 2023

Background

The need to improve the acute care pathway to meet the care needs of older people living with frailty is a strategic priority for many healthcare systems. The optimal care model for this patient group is unclear.

Methods

A systematic review was conducted to derive a taxonomy of acute care models for older people with acute medical illness and describe the outcomes used to assess their effectiveness. Care models providing time-limited episodes of care (up to 14 days) within 48 h of presentation to patients over the age of 65 with acute medical illness were included. Care models based in hospital and community settings were eligible.

Searches were undertaken in Medline, Embase, CINAHL and Cochrane databases. Interventions were described and classified in detail using a modified version of the TIDIeR checklist for complex interventions. Outcomes were described and classified using the Core Outcome Measures in Effectiveness Trials (COMET) taxonomy. Risk of bias was assessed using RoB2 and ROBINS-I.

Results

The inclusion criteria were met by 103 articles. Four classes of acute care model were identified, acute-bed based care, hospital at home, emergency department in-reach and care home models. The field is dominated by small single centre randomised and non-randomised studies. Most studies were judged to be at risk of bias. A range of outcome measures were reported with little consistency between studies. Evidence of effectiveness was limited.

Conclusion

Acute care models for older people living with frailty are heterogenous. The clinical effectiveness of these models cannot be conclusively established from the available evidence.

Trial registration

PROSPERO registration (CRD42021279131).
Being an older hospitalized patient during the COVID-19 pandemic - A qualitative interview study
Authors: Östlund Ann-Sofi , Högnelid Julia , Olsson Annakarin
Published: December 2023

Background

Older people hospitalized for COVID-19 are a vulnerable group due to the disease itself, aging and often loss of hearing and vision. Person-centered care, where patients have opportunities to communicate and participate in their own care, is important. However, because healthcare staff needed to wear personal protective equipment during the pandemic, to protect the patients and themselves, providing person-centered care was often difficult. This study aims to describe older hospitalized patients’ experiences both of being cared for, while having COVID-19, and of the care provided by healthcare staff wearing PPE.

Methods

Fourteen older patients, over 65 years of age, were interviewed, and the data were analyzed using qualitative content analysis. The study adhered to Consolidated criteria for reporting qualitative research guidelines.

Results

Three subthemes and one overall theme, “The desire for survival overshadows difficulties”, emerged in the analysis. The main findings revealed that the older hospitalized patients experienced the care they received from the healthcare staff as satisfactory. The older patients reported understanding and accepting that the pandemic situation meant that their ability to participate in their own care and communicate with healthcare staff were given lower priority.

Conclusions

Older hospitalized patients need to be provided person-centered care, and situations such as a pandemic are no exception. Care tasks that are not acute in nature, e.g., planning for patients’ return home, could be conducted by healthcare staff not required to wear PPE.
Association of PTX3 gene polymorphisms and PTX3 plasma levels with leprosy susceptibility
Authors: Moraes Ana Clara Cadidé Gonzaga , da Luz Renata Clesia Feitosa Viana , Fernandes André Luís Magalhães , Barbosa Milena Xavier Silva , de Andrade Lorena Viana , Armstrong Anderson da Costa , de Souza Carlos Dornels Freire , do Carmo Rodrigo Feliciano
Published: December 2023

Background

Pentraxin 3 (PTX3) is a soluble pattern recognition receptor that plays a crucial role in modulating the inflammatory response and activating the complement system. Additionally, plasma PTX3 has emerged as a potential biomarker for various infectious diseases. The aim of this study was to evaluate the association of PTX3 gene polymorphisms and PTX3 plasma levels with susceptibility to leprosy and clinical characteristics.

Methods

Patients with leprosy from a hyperendemic area in the Northeast Region of Brazil were included. Healthy household contacts and healthy blood donors from the same geographical area were recruited as a control group. The rs1840680 and rs2305619 polymorphisms of PTX3 were determined by real-time PCR. Plasma levels of PTX3 were determined by ELISA.

Results

A total of 512 individuals were included. Of these, 273 were patients diagnosed with leprosy; 53 were household contacts, and 186 were healthy blood donors. No association was observed between PTX3 polymorphisms and susceptibility to leprosy or development of leprosy reaction or physical disability. On the other hand, plasma levels of PTX3 were significantly higher in patients with leprosy when compared to household contacts (p = 0.003) or blood donors (p = 0.04). It was also observed that PTX3 levels drop significantly after multidrug therapy (p < 0.0001).

Conclusions

Our results suggest that PTX3 may play an important role in the pathogenesis of leprosy and point to the potential use of this molecule as an infection marker.
Predictors of problematic smartphone use among young adult lesbian, gay and bisexual individuals during the COVID-19 pandemic: a four-year follow-up study
Authors: Huang Mei-Feng , Chang Yu-Ping , Chou Wen-Jiun , Yen Cheng-Fang
Published: December 2023

Background

This 4-year follow-up study was conducted to evaluate the predictive effects of prepandemic individual and environmental factors on problematic smartphone use (PSU) among young adult lesbian, gay, and bisexual (LGB) individuals during the COVID-19 pandemic.

Methods

Data on prepandemic PSU, demographics, sexual stigma (e.g., perceived sexual stigma from family members, internalized sexual stigma, and sexual microaggression), self-identity confusion (e.g., disturbed identity, unconsolidated identity, and lack of identity), anxiety, depression, and family support were collected from 1,000 LGB individuals between August 2018 and June 2019. The participants’ PSU was surveyed again after 4 years (between August 2022 and June 2023). The associations of prepandemic individual and environmental factors with PSU at follow-up were analyzed through linear regression.

Results

In total, 673 (67.3%) participants completed the follow-up assessment. The severity of PSU significantly decreased after 4 years (p = .001). Before the incorporation of PSU at baseline into the analysis model, the results of the model revealed that high levels depressive symptoms (p < .001), disturbed identity (p < .001), and perceived sexual stigma from family members (p = .025) at baseline were significantly associated with PSU at follow-up. After the incorporation of PSU at baseline into the analysis model, the results of the model revealed that high levels PSU (p < .001) and depressive symptoms (p = .002) at baseline were significantly associated with PSU at follow-up.

Conclusion

Interventions aimed at reducing the severity of PSU among LGB individuals should be designed considering the predictors identified in our study.
Investigating the role of symptom valorisation in tuberculosis patient delay in urban areas in Portugal
Authors: de Morais Margarida , Sousa Sofia , Marques Jéssica , Moniz Marta , Duarte Raquel , Leite Andreia , Soares Patrícia ,   URBANTB group, Carreira Mário , Pereira Sofia , Alves Catarina , Alves Filipe , Rodrigues Ana , Moreira Ana , Cardoso Márcia , Mota Sandra , Gomes Ana , Ferreira Liliana , Lopes Marta , Correia Isabel , Rachadell Juan , Gameiro Maria , Dias Ângela , Pereira Manuel , Gonçalves Jorge , Gonçalves Maria , Taveira Adriana , Neves Celene , Silva Lucinda , Mendes Maria , Teixeira Maria , Pereira Maria , Piedade Milena , Teixeira Antónia , Carvalho Carlos
Published: December 2023

Background

Diagnosis delay contributes to increased tuberculosis (TB) transmission and morbimortality. TB incidence has been decreasing in Portugal, but median patient delay (PD) has risen. Symptom valorisation may determine PD by influencing help-seeking behaviour. We aimed to analyse the association between symptom valorisation and PD, while characterising individuals who disregarded their symptoms.

Methods

A cross-sectional study was conducted among TB patients in Lisbon and Oporto in 2019 – 2021. Subjects who delayed seeking care because they did not value their symptoms or thought these would go away on their own were considered to have disregarded their symptoms. PD was categorised using a 21-day cut-off, and a 30-day cut-off for sensitivity analysis. We estimated the effect of symptom valorisation on PD through a directed acyclic graph. Then, a multivariable regression analysis characterised patients that disregarded their symptoms, adjusting for relevant variables. We fitted Poisson regression models to estimate crude and adjusted prevalence ratios (PR).

Results

The study included 75 patients. Median PD was 25 days (IQR 11.5–63.5), and 56.0% of participants had PD exceeding 21 days. Symptom disregard was reported by 38.7% of patients. Patients who did not value their symptoms had higher prevalence of PD exceeding 21 days compared to those who valued their symptoms [PR 1.59 (95% CI 1.05–2.42)]. The sensitivity analysis showed consistent point estimates but wider confidence intervals [PR 1.39 (95% CI 0.77–2.55)]. Being a smoker was a risk factor for symptom disregard [PR 2.35 (95% CI 1.14–4.82)], while living in Oporto [PR 0.35 (95% CI 0.16–0.75)] and having higher household incomes [PR 0.39 (95% CI 0.17–0.94)] were protective factors.

Conclusions

These findings emphasise the importance of symptom valorisation in timely TB diagnosis. Patients who did not value their symptoms had longer PD, indicating a need for interventions to improve symptom recognition. Our findings also corroborate the importance of the socioeconomic determinants of health, highlighting tobacco as a risk factor both for TB and for PD.
Association between personality characteristics and sleep quality among Chinese middle-aged and older adults: evidence from China family panel studies
Authors: Wang Zhen , Zeng Zhi
Published: December 2023

Background

Poor sleep quality will have adverse effects on physical and mental health, quality of life and other aspects of middle-aged and older adults. Sleep quality is affected by many factors. Whether the sleep quality measures of the participants had changed in the previous or subsequent time period is not easily taken into account. Moreover, there have been no studies on this topic in Chinese middle-aged and older adults. The objective of this study was to mitigate the bias of sleep quality assessment, and analyze the association between personality traits and sleep quality in Chinese middle-aged and older adults.

Methods

The data came from the China Family Panel Studies (CFPS). A total of 6031 participants aged ≥ 45 years were included in this study. Personality characteristics were evaluated based on the scores of each dimension of Big Five personality traits. Sleep duration and sleep perception were used as indicators to measure sleep quality. Logistic models were used to analyze the relationship between personality traits and sleep duration or sleep perception, respectively.

Results

4.5% of the participants had abnormal sleep duration, and 14.4% had a pessimistic sleep perception. Conscientiousness was rated the highest among the personality traits (3.97 ± 0.6). Participants with higher scores for extraversion personality traits had more normal sleep duration (OR = 0.77, 95% CI: 0.64–0.93) and more optimistic sleep perception (OR = 0.86, 95% CI: 0.76–0.96). Using the Internet and feeling unwell in the past week have a moderating effect on the impact of conscientiousness personality characteristics on sleep duration or sleep perception, respectively (but not overall sleep quality). In addition, participants with a spouse or no recent physical discomfort tended to have a normal sleep duration and a more optimistic sleep perception.

Conclusions

The higher the score of extraversion personality traits, the better the overall sleep quality of middle-aged and older adults. Having a spouse and feeling unwell were the important factors affecting their sleep quality. Specific personality traits intervention should be carried out for middle-aged and older adults with poor sleep quality to make their personality traits are closer to extraversion. In addition, middle-aged and older adults without spouses should be encouraged to marry or remarry. We will strengthen health management and medical expenditures for middle-aged and older adults.
Modelling individual infancy growth trajectories to predict excessive gain in BMI z-score: a comparison of growth measures in the ABCD and GECKO Drenthe cohorts
Authors: Schreuder Anton , Corpeleijn Eva , Vrijkotte Tanja
Published: December 2023

Background

Excessive weight gain during childhood is a strong predictor for adult overweight, but it remains unknown which growth measures in infancy (0–2 years of age), besides predictors known at birth, are the strongest predictors for excessive weight gain between 2 and 5–7 years of age.

Methods

The Amsterdam Born Children and their Development (ABCD) study formed the derivation cohort, and the Groningen Expert Center for Kids with Obesity (GECKO) Drenthe study formed the validation cohort. Change (Δ) in body mass index (BMI) z-score between 2 and 5–7 years was the outcome of interest. The growth measures considered were weight, weight-for-length (WfL), and body mass index (BMI). Formats considered for each growth measure were values at 1, 6, 12, and 24 months, at the BMI peak, the change between aforementioned ages, and prepeak velocity. 10 model structures combining different variable formats and including predictors at birth were derived for each growth measure, resulting in 30 linear regression models. A Parsimonious Model considering all growth measures and a Birth Model considering none were also derived.

Results

The derivation cohort consisted of 3139 infants of which 373 (11.9%) had excessive gain in BMI z-score (> 0.67). The validation cohort contained 2201 infants of which 592 (26.9%) had excessive gain. Across the 3 growth measures, 5 model structures which included measures related to the BMI peak and prepeak velocity (derivation cohort area under the curve [AUC] range = 0.765–0.855) achieved more accurate estimates than 3 model structures which included growth measure change over time (0.706–0.795). All model structures which used BMI were superior to those using weight or WfL. The AUC across all models was on average 0.126 lower in the validation cohort. The Parsimonious Model’s AUCs in the derivation and validation cohorts were 0.856 and 0.766, respectively, compared to 0.690 and 0.491, respectively, for the Birth Model. The respective false positive rates were 28.2% and 20.1% for the Parsimonious Model and 70.0% and 74.6% for the Birth Model.

Conclusion

Models’ performances varied significantly across model structures and growth measures. Developing the optimal model requires extensive testing of the many possibilities.
Comorbidities of diabetes and hypertension in Vietnam: current burden, trends over time, and correlated factors
Authors: Vu Thi Hoang Lan , Bui Thi Tu Quyen , Tran Quoc Bao , Pham Quynh Nga , Lai Duc Truong , Le Tu Hoang , Minh Hoang Van
Published: December 2023

Background

Vietnam conducted the national Noncommunicable Disease Risk-Factor Surveillance (STEPs) surveys in the years 2010, 2015, and 2021. This study aims to use STEPs data to assess the burden of comorbidity between diabetes and hypertension, analyze trends over time, and identify factors associated with this comorbidity.

Methods

The study extracted data for the population aged 25–64 years old from three STEPs surveys. Survey weight was used for all estimations of prevalence and 95% CI. Correlated factors with comorbidity were examined by a multivariate logistics model.

Results

The prevalence of comorbidity in 2021 was about 3.92% among Vietnamese people aged 25–64. In the last 10 years, this prevalence has increased more than 8 times (from 0.44% to 3.92%). Sub-populations demonstrating the most significant changes included the male population, people living in urban areas, and older people. Significant factors correlated with comorbidity included demographic factors, body mass index (BMI), and clustering of 4 noncommunicable diseases (NCDs) behavioral risk factors (OR = 3.48, p < 0.05).

Conclusion

The high comorbidity between hypertension and diabetes underscores the imperative for integrated treatment and management approaches in Vietnam. Coordinated care is essential for addressing the complex interplay between these two prevalent conditions.
An efficacy and safety evaluation of montelukast + fluticasone propionate vs. fluticasone propionate in the treatment of cough variant asthma in children: a meta-analysis
Authors: Wei Zhengbo , Li Sheng
Published: December 2023

Purpose

This study aimed to evaluate the efficacy and safety of montelukast (Mon) + fluticasone propionate (Flu) versus Flu in the treatment of cough variant asthma (CVA) in children.

Methods

Eligible documents were selected from various databases. Weighted mean difference (WMD) and 95% confidence interval (CI) were used to evaluate continuous variables, and categorical variables were evaluated using risk ratio (RR) and 95% CI. Heterogeneity analysis was performed using Cochran’s Q test and I2 statistics, followed by sensitivity analysis and publication bias evaluation.

Results

Nine studies were included, and Flu + Mon was found to significantly improve the total effective rate and reduce cough recurrence compared to Flu. The cough remission and disappearance times in the Mon + Flu group were significantly lower than those in the Flu group. FEV1% recovery in the Mon + Flu group was significantly better than that in the Flu group.

Conclusion

Mon + Flu is effective and safe for the treatment of CVA in children.
Fractional Exhalation Nitric Oxide (FeNO) changes in cystic fibrosis patients induced by compound honey syrup: a pretest–posttest clinical trial
Authors: Sadr Saeed , Tahermohammadi Hanieh , Kaveh Shahpar , Khanbabaee Ghamartaj , Tabatabaei Seyed Ahmad , Choopani Rasool , Rouzbahani Arian Karimi , Fadavi Nafise , Derikvandi Shima
Published: December 2023

Objective

To evaluate the effect of Persian medicine Syrup ‘compound honey syrup (CHS)’ on fractional exhalation nitric oxide (FENO) changes in patients with cystic fibrosis (CF).

Study design

We conducted a before-after clinical trial on 70 CF patients. All patients received classical treatments for CF along with CHS (including honey, Ginger, cinnamon, saffron, cardamom and galangal), 5–10 cc (depending on the age and weight of patients) in 100 cc of warm boiled water twice a day, 30 min after meals. In this clinical trial, before and 12 weeks after the start of the CHS, FeNO test was evaluated.

Results

From 70 patients were enrolled, 44 patients completed this 12-week course of treatment. At the end of the study, changes in FeNO was significantly different before and after treatment (P-value < 0.05). At the end of the study, no dangerous side effects of CHS was reported.

Conclusions

This study revealed that CHS can be effective as a complementary and safe drug in the medication of CF patients.
Evaluation of the marginal adaptation and debonding strength of two types of CAD-CAM implant-supported cement-retained crowns
Authors: Ramzy Nada Ahmed , Azer Amir Shoukry , Khamis Mohamed Moataz
Published: December 2023

Background

In-vitro data from a clinically well-known lithium disilicate ceramic reference was used to assess the expected performance of resin-based materials in implant dentistry. The purpose of the study was to compare the bond strength and marginal adaptation of nano-ceramic hybrid composite crowns cemented to stock cement-retained abutments to lithium disilicate crowns.

Methods

Twenty abutment analogs were embedded into auto-polymerizing acrylic resin blocks. The blocks were divided into 2 groups according to the restorative crown material. The 2 groups were divided as follows: Resin nano-ceramic group and lithium disilicate group. Abutment analogs in both groups were scanned using a laboratory scanner, and the restorations were designed, manufactured, and cemented with resin cement over the corresponding group. All samples were tested for marginal adaptation and bond strength after storage for 24 hours at 37 °C in 100% humidity. Data were collected, tabulated, and statistically analysed using the appropriate tests. Normality was checked using Shapiro Wilk test and Q-Q plots. Data were normally distributed. Variables were presented using mean, 95% Confidence Interval (CI) and standard deviation in addition to median and Inter Quartile Range (IQR). Differences between groups regarding debonding forces was assessed using independent t test. Two Way ANOVA was performed to assess the effect of material and bonding on marginal gap. All tests were two tailed and p value was set at < 0.05.

Results

Marginal gap and debonding force values were significantly different according to the type of material used (P < .05). Resin nano-ceramic crowns presented lower marginal gap values before (20.80 ± 8.87 μm) and after (52.11 ± 22.92 μm) bonding than lithium disilicate crowns. The debonding force value for resin nano-ceramic crowns (284.30 ± 26.44 N) was significantly higher than that for lithium disilicate crowns (253.30 ± 33.26 N). Adhesive failure mode was detected in all the specimens in both groups.

Conclusions

The type of material used for implant-supported cement-retained crowns had a statistically significant effect on marginal adaptation and bond strength. Resin nano-ceramic implant-supported cement-retained crowns had better marginal adaptation and higher bond strength than those manufactured using lithium disilicate.
Associations between the 3D position of the mental foramen with sagittal skeletal relationships (classes I, II, and III) and vertical facial growth patterns (normal, long, and short faces) in different ages and sexes: a retrospective cohort study of 360 CBCTs
Authors: Bagheri Sepideh , Shokuhifar Mohammadreza , Moradinejad Mehrnaz , Razavi Mahshid , Hashemi Ashtiani Alireza , Baratvand Behnaz , Rakhshan Vahid
Published: December 2023

Background

The 3D position of the mental foramen (MF) is of significant clinical value in dental implantology and mandibular surgeries or in local anesthesia. Despite its importance, it is not clearly known how the position of MF can alter in different individuals, since the literature on the associations between the MF position with vertical growth patterns is non-existent and those on links between the MF position and skeletal malocclusions are scarce. Therefore, we aimed to investigate these, for the first time, on cone-beam computed tomographies (CBCTs).

Methods

Archival CBCTs of 9 sub-groups (i.e., 3 skeletal Classes I, II, and III × 3 vertical growth patterns ‘long face, short face, normal face’) were collected by evaluating patients’ SNA, SNB, ANB, facial angle, lower facial height, and FMA (n = 9 × 40 = 360). Included cases were older than 17 years and without any history of orthodontic/orthognathic treatments (243 women, 117 men, mean age: 22.28 ± 2.80 years). Perpendicular distances between the MF and 3 fixed bony structures (the mandibular symphysis [S/width], the mandibular ramus [R/length], and the mandibular lower cortex [C/height]) were measured on different sectional planes on both hemimandibles. Left- and right-side measurements were combined. Data were analyzed using the 3-way ANCOVA, Bonferroni, one-way ANOVA, Tamhane, Pearson, and t-test (α = 0.05).

Results

Width was the smallest in Class II and greatest in Class III cases (all P values < 0.000001, Bonferroni). It was the shortest in long faces and longest in short faces (all P values ≤ 0.00008). The inferior-superior height was larger in Class III than both Classes I and II (both P values ≤ 0.003); there was no significant difference between Classes I and II in terms of height (P = 0.684). Height was the largest in long faces and smallest in short faces (all P values < 0.000001). The anterior-posterior length was the largest in Class III and smallest in Class II (all P values < 0.000001). Length was larger in short-face people versus normal- or long-face individuals (P ≤ 0.00003); nevertheless, long and normal faces did not differ in terms of length (P = 0.448). Subjects’ age was not correlated with their MF positions (P ≥ 0.579, Pearson coefficient). Sex dimorphism existed only for height (P = 0.009, t-test) but not for length or width.

Conclusions

The MF position may considerably differ in various horizontal or vertical growth patterns and sexes. This should be noted in mandible surgeries.