bluuebunny/crossref_metadata_2025 huggingface dataset:
Evaluación toxicológica de los sedimentos marinos del estero Huaylá, usando como bioindicador al nematodo C. elegans
Authors: González Carrasco Víctor Hugo , Tejeda Benítez Lesly Patricia , Pilaloa Tamayo1 Juan Carlos
Published: April 2022

El Estero Huaylá, ubicado en la Provincia de El Oro (Ecuador) ha sido impactado, química y biológicamente, por diferentes actividades antropogénicas como la industria agrícola, camaronera, laboratorios de criaderos de larvas, aguas servidas y descargas directas de efluentes domésticos sin el tratamiento adecuado. En este trabajo se determinó la presencia de metales como el mercurio y el plomo en los sedimentos marinos y su toxicidad usando Caenorhabditis elegans como modelo. Muestras de sedimentos de nueve sitios del estero fueron secados y analizados para determinar el contenido de mercurio y plomo por espectrofotometría de absorción atómica con nebulización de llama y con la generación de hidruros con atomización en una celda de cuarzo. Para evaluar la toxicidad, C. elegans fue expuesto a extractos acuosos de los sedimentos, cambios en parámetros biológicos tales como mortalidad, locomoción, crecimiento, reproducción y bioquímicos fueron registrados a través de la expresión de genes como respuesta al estrés por metales y a estrés oxidativo a través de las cepas transgénicas mtl-2::gfp y sod-4::gfp, respectivamente. Los resultados demuestran que la concentración de mercurio fue elevada en todas las estaciones, y la de plomo fue baja. Los nemátodos silvestres expuestos a los extractos de los sedimentos mostraron efectos en la mortalidad, crecimiento, locomoción y reproducción. Los nemátodos transgénicos presentaron sobreexpresión de los genes mtl-2 y sod-4. En general, las estaciones con mayor concentración de mercurio y mayor toxicidad fueron aquellos situadas en las distribuidoras de fertilizantes y cal para camaroneras y cerca de las estaciones de gasolina.
Características físicas y químicas del pescado ratón silvestre (Leporinus ecuadorensis) en la zona sur de la provincia de Los Ríos.
Authors: Triviño Bravo Josselin Lisseth , Herrera Mena Félix Vicente , Roca Cedeño Jacinto Alex , Rivera Legton Carlos Alfredo , Sornoza Zambrano Willian Oswaldo , Pincay Jiménez Roberto Carlos
Published: April 2022

Con el propósito de estudiar las características físicas y químicas del ratón silvestre (Leporinus ecuadorensis) y proporcionar una base de datos con información de este pez que habita en el río Babahoyo, se realizó este trabajo en el Rio Babahoyo, donde fueron capturados 250 especímenes de Leporinus e., los cuales tuvieron un rango de peso de 75-175 g, estos fueron transportados a la planta de cárnicos del Campus “La María” de la Universidad Técnica Estatal de Quevedo donde se realizaron los análisis físicos (Colorimetría R G B, perdidas por cocción y goteo, pH), para los análisis de composición química y mineral de la carne se llevaron muestras de la misma al Laboratorio de Química de la Universidad Tecnológica Equinoccial Sede Santo Domingo a lo que se aplicó una estadística descriptiva. La carne de Leporinus e. presento un contenido de proteína de 22.08% y bajo contenido de grasa 4.68% por lo que se considera que estos peces se encuentran dentro del grupo de especies de grasa media. Por los resultados de los análisis físicos realizados es una carne azulada y presenta bajas pérdidas de agua por goteo y cocción (4.69 y 19.95% respectivamente) en comparación con otras especies
Efecto de la asociación de ajo (Allium sativum L.) y cebolla (Allium cepa L.) en la producción de maracuyá (Passiflora edulis Sims.) durante la etapa de plántula
Authors: Camilo Alexander Mestanza Uquillas , Diana Verónica Véliz Zamora , Lizbeth Isabel Icaza Franco , Santiago Cristóbal Vásquez Matute
Published: April 2022

Para una producción adecuada de maracuyá es indispensable el uso de semilla de calidad y la obtención de plántulas libres de plagas y enfermedades, que brinden las condiciones propicias para su crecimiento durante la etapa inicial de desarrollo. Basado en este antecedente, se evaluó el efecto de la asociación de maracuyá (Passiflora edulis) + cebolla (Allium cepa) + ajo (Allium sativum), en dos diferentes sustratos: Sin desinfectar y Desinfectado. Se aplicó un diseño experimental completamente al azar con un arreglo bifactorial (2 tipo de suelo x 2 sistema de cultivo), generando cuatro interacciones: Sin desinfectar-Solo, Sin desinfectar-Asociado, Desinfectado-Solo y Desinfectado-Asociado, dispuestos en cuatro repeticiones. La siembra se realizó en platabandas de 2 m2 bajo condiciones de campo. Los resultados para germinación y plantas muertas demostraron diferencias significativas (P<0.05) para los tratamientos de sistemas asociados a los 15 y 50 días después de la siembra. Respecto al comportamiento agronómico las interacciones de sistemas asociados se pudieron evidenciar una respuesta positiva en las variables altura de planta, peso fresco aéreo y radical, biomasa aérea y radical. Los niveles de nitrógeno, fósforo, potasio y azufre se incrementaron hasta llegar a niveles adecuados. La asociación de maracuyá y especies del género Allium benefician la producción de plántulas mejorando la sobrevivencia, desarrollo y nutrición de la planta y del suelo.
La cadena de valor del coco (Cocos nucifera L.) y su productividad
Authors: Zambrano-Montesdeoca Jasson , Palacios-Cedeño Nohemí , Alcívar-Meza Ana , Alcívar-Meza María , Arana-Sánchez Denisse , Macías-Loor Carlos
Published: April 2022

El presente trabajo investigativo se desarrolló en la parroquia Rio Chico, un sector rural del cantón Portoviejo, República del Ecuador; tuvo como objetivo principal analizar la cadena de valor del coco y su productividad en la parroquia Rio Chico. Se realizó un estudio a través de metodologías descriptivas, no experimental y de campo, que acercan a la realidad del sector productivo, por otro lado, se evidencia el tipo de investigación cuantitativa y cualitativa, habiéndose analizado el lugar de estudio, como también tablas y representaciones estadísticas, propias de este tipo de investigación. Así también, intervinieron representantes de la asociación ASOCOCOEBANITOS escogida, que produce el Aceite de Coco, producto analizado en este trabajo, de manera que el tema indicaría un estudio profundo para un mejor desarrollo de esta investigación. Los resultados evidencian que la Asociación no cuenta con canales de comercialización y distribución adecuados para poder vender su producto, solamente lo hacen ya por requerimientos, lo que afecta tanto a la economía de ellos mismos, como a la del sector, en lo que se refiere a la transformación de la materia prima para obtener productos elaborados de aceite de coco, el proceso es muy bien manejado por los habitantes de la asociación, sin embargo, la composición química del mismo no está asesorada por profesionales en el campo, y la producción no es constante, solamente se realiza el producto cuando existen ferias y cuando hay pedidos, que no es muy común.
Digestibilidad gástrica y duodenal in vitro de aislados proteicos del huevo de codorniz
Authors: Barrionuevo Alejandra , Cornelio Jéssica , Barba Capote Cecilio , Ramos Cynthia
Published: April 2022

Aislamos la proteína por su punto isoeléctrico, cuantificar, caracterizar y someterlas a estudios de digestión in vitro. Tomando en cuenta 4 tipos de muestras para comprobar, a medida que pase el tiempo las proteínas se conservan o se pierden. Huevos recolectados a las 12 horas después de la postura mostraron que poseían un valor proteico de 87.22%, huevos de 24 horas 87,80%, huevos de 48 horas 86.26% y huevos 72 horas recolectados después de la postura 90.28%, demostrándonos que el huevo de codorniz tiene un alto valor proteico comparado con el huevo de gallina. En la caracterización proteica a través de electroforesis SDS-PAGE, pudimos evaluar los tipos de proteína que este producto posee tomando en cuenta que se aisló lisozima y ovomucina por lo que en este estudio sus bandas casi son inexistente. Ovotransferrina (77kDa), Avidin (65-69ka), Ovoglobulina G3 (50-55 kDa), Ovoalbúmina (39 kDa) y fracciones de Lisozima (12kDa), observadas en todas las muestras estudiadas por ende estas proteínas se conservan si no son sometidas a cambios bruscos de temperatura mayores de 50°C y menores de 25°C. Por lo tanto para la simulación del proceso gastrointestinal in vitro se utilizaron enzimas como la pepsina, pancreatina y sales biliares, preparándolas a distintos pHs y simular el estómago de una persona que padece problemas gastrointestinales pH 1.2 estómago de una persona adulta sana pH 2.0 y niño no lactante pH 3.2; determinamos que las proteínas del huevo de codorniz son totalmente digeridas a pH 1.2 y a pH 3.2 la proteína ovotranferrina y ovoalbúmina presentan inconvenientes para su digerido total.
Garcilaso en Ercilla
Authors: Isaías Lerner
Published: April 2022

Esteartículo no presenta resúmen
Kurt Baldinger. Teoría semántica. Hacia una semántica moderna, Madrid (Ediciones Alcalá), segunda edición corregida y aumentada, 1977, 302 pp.
Authors: Rivarola José Luis
Published: April 2022

Este artículo no presenta resúmen
La primera persona posesora-actora del protoquechua
Authors: Cerrón-Palomino Rodolfo
Published: April 2022

No presenta resúmen
El rehilamiento en el español hablado en la región andina del Ecuador
Authors: Argüello Fanny M.
Published: April 2022

El artículo no presenta resumen.
Enseñanza de idiomas en la educación peruana : a propósito de un libro de la Fédération Internationale des Professeurs de Langues Vivantes (FIPLV)
Authors: Vanden Eynden Michele
Published: April 2022

El artículo no presenta resumen.
Impact of Undergraduate Research Training Programs: An Illustrative Example of Finding a Comparison Group and Evaluating Academic and Graduate School Outcomes
Authors:   University of California, Los Angeles, Stormes Kaitlyn N. , Streicker Nicole A. ,   California State University, Long Beach, Bowers Graham K. ,   University of California, Los Angeles, Ayala Perla ,   California State University, Long Beach, Urizar Guido G. ,   California State University, Long Beach
Published: April 2022

In this study, researchers at a large, urban, comprehensive minority-serving institution used propensity score matching to identify a unique comparison group to study academic and graduate school outcomes in students served by the National Institutes of Health–funded Building Infrastructure Leading to Diversity (BUILD) Initiative. Acknowledging that students’ self-selection biases may confound findings, the use of propensity methods to match students served with those who were not (but were otherwise eligible) provides a valuable tool for evaluators and practitioners to combat this challenge and better evaluate their effectiveness and impact on students’ success. This study’s findings indicate that BUILD participants had higher academic and graduate school success with regard to cumulative GPA, units attempted and completed, graduation status, and application and admission to graduate programs.
Pencegahan Penyakit Lisan Melalui Layanan Informasi Berbasis Hadits (Studi Kualitatif Pada Mahasiswa)
Authors: Jannati Zhila
Published: April 2022

Oral is very important to be maintained so that oral disease does not occur. The purpose of this study was to find out how to prevent oral disease through hadith-based information services for Islamic Guidance and Counseling students at UIN Raden Fatah Palembang. This research is a qualitative research. The subjects of this study were 30 students from the Islamic Guidance and Counseling Study Program. The data collection techniques in this study were using observation and interview techniques. The result of this study is that the implementation of hadith-based information services in preventing oral disease is carried out through five stages, namely planning, organizing service elements and targets, implementation, assessment, and follow-up and reports. Thus, it can be concluded that hadith-based information services can be an alternative in preventing oral diseases in students from the Islamic Guidance and Counseling Study Program.
ANALISIS PERBANDINGAN PENETAPAN HAKIM TERHADAP DISPENSASI PERKAWINAN AKIBAT HAMIL DILUAR NIKAH
Authors: Ekasari Ekasari , Fathimah Ema , Gibtiah Gibtiah
Published: April 2022

Abstract

One of the marriage dispensation cases that was granted by the Palembang Class IA religious court was assurance Number: 310/Pdt.P/2020/PA.PLG and what was rejected by the Banjarnegara religious court was assurance number: 66/Pdt.P/2019/PA.Ba. The interesting thing in this determination is the difference in the lawful fundamental for the consideration of the Palembang religious court judges in granting and the Banjarnegara religious court judges in rejecting the dispensation application submitted by the applicants. However, the substance of both is the same. The problem and goal of this inquire about is to discover out the  basis in law, similarities and differences in the legal reason of the judge's thought of the two choices. This investigate may be a sort of normative juridical inquiry. The type of data used is qualitative data. Data analysis methods used are deductive and comparative methods. The results of the study show that the legal basis for the justice granting the application for dispensation for marriage is article 7 paragraph 2 of law number 1 of 1974 concerning marriage as revise by law number 16 of 2019, article 26 paragraph 1 letter a of law number 35 of 2014 concerning amendments to law number 23 of 2002 concerning child protection. In addition, the judge also uses the rules of fiqh, namely Saad al-Dzariah. The judge's legal basis for rejecting the application for a marriage dispensation is article 7 paragraph 1 of law number 1 of 1974 concerning marriage and article 1 number 1 of law number 35 of 2014 concerning amendments to law number 23 of 2002 concerning child protection. The similarity is that they both have the same substance. The difference is that the Palembang religious court judge granted it and the Banjarnegara religious court judge rejected the marriage dispensation application due to pregnancy out of wedlock.   

Keywords: Marriage, Dispensation, Marriage Age Limit
Silisyum İnce Filmlerde Taban Malzemelerin Elektronik Kusurlar Üzerine Etkisinin Belirlenmesi
Authors: Yılmaz Gökhan
Published: April 2022

Silisyum ince filmlerin taban malzeme ve üretim koşullarına bağlı olarak kristal hacim oranları değişmektedir. Kristal hacim oranlarındaki bu farklılık ince filmlerin yasak enerji aralığında bulunun elektronik kusur çeşitlerini de etkilemektedir. Silisyum ince filmlerde atmosferik koşullardan ya da uzun süre ışığa maruz kalmalarından kaynaklı olarak elektronik kusurlar oluşmaktadır. Elektronik kusurların değişimine bağlı olarak iletkenlik değerlerinde değişimler oluşmaktadır. Bu çalışmada PECVD tekniği kullanılarak aynı anda üç farklı taban malzeme üzerine silisyum ince filmler büyütülmüştür. Büyütülen filmlerin kristal hacim oranları Raman Spektroskopisi ile yüzey morfolojileri ise taramalı elektron mikroskobu (SEM) yöntemi ile belirlenmiştir. Büyütülen silisyum ince filmler farklı atmosferik koşullara ( laboratuvar atmosferi, ışık banyosu ve UV ışık yaşlandırmasına) maruz bırakılarak bilinçli bir şekilde ince filmlerin yapısında elektronik kusurlar oluşturulmuştur. Bu kusurların davranışı elektriksel iletkenlik yöntemleri olan zamana bağlı karanlık iletkenlik, fotoiletkenlik ve mobilite-yaşam süresi hesaplamaları ile incelenmiştir. Elde edilen bulgular sonucunda taban malzemelerin farklı olmasından kaynaklı malzemelerin kristal hacim oranlarında ve kalınlıklarında belirgin farklılıklar oluştuğu ve bu farklılıklardan kaynaklı olarak malzemelerin aynı atmosferik koşullarda farklı elektronik kusur durumlarından etkilendikleri belirlenmiştir.
Utilização de análise de imagem para avaliação da qualidade de sementes de Passiflora cincinnata (maracujá-do-mato)
Authors: Luz Petterson Baptista da , Fernanda Silva Lima Beatriz , Sobrinho Severino de Paiva , Oliveira Andréa dos Santos
Published: April 2022

O objetivo do trabalho foi avaliar a qualidade de sementes de Passiflora cincinnata em função do estádio de desenvolvimento do fruto por meio de teste de raios-X e análise de imagem. Para a realização do teste de raios-X e da análise de imagem, foram utilizadas quatro repetições de 50 sementes para cada estádio de maturação do fruto (verde, “de vez”, maduro e senescente). As sementes submetidas à exposição em raios-X foram classificadas em cheias ou vazias. Para análise de imagem computadorizada, avaliaram-se 15 descritores relacionados à dominância de cores e 7 de geometria. Posteriormente, as sementes foram avaliadas quanto à germinação. Os resultados obtidos indicam diferenças de coloração e de geometria entre os estádios de maturação dos frutos e que não houve diferença estatística entre os estádios no teste de raios-X. As sementes podem ser coletadas de frutos nos estádios maduro e senescente, sem prejuízo à qualidade fisiológica.
A teoria, o discurso e a realidade em uma Escola Integral de Tempo Integral em Campo Grande, MS
Authors: Santos Regerson Franklin dos
Published: April 2022

Este texto apresenta a análise do ciclo de aprendizagem (2017/2018/2019) desenvolvido com estudantes do Ensino Médio na/da Escola Estadual Waldemir Barros da Silva, localizada na periferia sul da cidade de Campo Grande, MS. Os componentes da Parte Diversificada, as Metodologias Ativas e os demais instrumentos didático-pedagógicos, característicos de uma Escola Integral de Tempo Integral, foram os objetos desta investigação (sobretudo qualitativa), que ocorreu mediante aplicação de questionários semiestruturados a 90 estudantes de um total de 132. Todo esse arcabouço possibilitou ao pesquisador-participante observar o quanto as políticas públicas são incipientes, descontínuas e dotadas de muito discurso, mas pouca concretude, comprometendo a realização de uma educação de qualidade. A ausência, na educação, de uma Política de Estado, as mudanças no Novo Ensino Médio e a velocidade de seu alcance são os grandes obstáculos a serem vencidos. Mesmo com esses percalços, concluiu-se que a aprendizagem no/do ciclo analisado foi exitosa.
A CORRELAÇÃO ENTRE VERTICALIZAÇÃO, DENSIDADE E URBANIDADE: ESTUDO DE CASO DOS EDIFÍCIOS VERTICAIS DA REGIÃO NORTE DE PALMAS-TO
Authors: Galvão Gomes Pedro Igor , Albieri de Oliveira Lucimara
Published: April 2022

O artigo analisa as questões relativas à urbanidade em uma quadra comercial no centro projetado da cidade de Palmas-TO. A urbanidade é entendida por meio das trocas sociais que se estabelecem no espaço público, porém necessitam da densidade e da diversidade do meio físico para que ela se estabeleça com plenitude. A investigação se dá pela análise da densidade construtiva e da diversidade do uso do solo em uma capital recentemente implantada no Brasil, implementada a partir de um projeto urbanístico que determinou o centro da cidade, a despeito da ausência de uma construção social e de uma densidade histórica que viria a dar conteúdo a tal centro. Além disto, a cidade sofreu um esgarçamento e um espraiamento prematuro que implicou significativamente na falta de consolidação de seu centro. O artigo demonstrou que a falta de continuidade na implantação de edifícios verticais de uso misto no centro de Palmas comprometeu substancialmente a conformação de um espaço urbano que promovesse a urbanidade.

Palavras-chave: Urbanidade. Densidade. Verticalização.
Platinum is essential in neoadjuvant treatment of triple-negative breast cancer: a network meta-analysis
Authors: Li Junjie , Chen Li , Tan Wei , Qi Fang , Zhang Yang , Wang Zhonghua , Shao Zhimin
Published: April 2022

Objective: This study aimed to assess the efficacy and safety of various neoadjuvant regimens for patients diagnosed with early-stage or locally advanced triple-negative breast cancer (TNBC). Methods: Medline, EMBASE, Cochrane Library, and Web of Science were searched in May 2020 to identify randomized controlled trials (RCTs). Bayesian network meta-analysis (NMA) was performed (Registration: PROSPERO CRD42020223012). Results: A total of 35 RCTs involving 8,424 participants were reviewed, of which 22 RCTs with 5,203 patients were included in this NMA focusing on pathologic complete response (pCR). An anthracycline-taxane-based (AT) regimen combined with a platinum (ATPt) [odds ratio (OR) = 2.04, 95% credible interval (CrI): 1.69, 2.48] regimen, and a docetaxel regimen combined with a carboplatin (TCb; OR = 2.16, 95% CrI: 1.20, 3.91) regimen improved pCR beyond that with AT only. AT and ATPt combined with targeted therapy [including bevacizumab (Bev), veliparib, atezolizumab, or pembrolizumab] also improved pCR. Five RCTs included in this NMA reported serious adverse events (SAEs) or grade ≥ 3 AEs. TCb was associated with fewer grade ≥ 3 AEs than was AT (OR = 0.66, 95% CrI: 0.23, 1.72) alone. In contrast, ATPt, AT + Bev, ATPt + Bev, ATPt + veliparib, and ATPt + pembrolizumab were associated with more SAEs than was AT alone. Conclusions: In patients with TNBC, platinum-based neoadjuvant regimens ATPt and TCb increase pCR beyond that with AT alone, but TCb appears to be better tolerated than either AT or ATPt. Platinum-based regimens combined with targeted therapies (Bev, PARPi, and PD-1/PD-L1 inhibitor) also improve the pCR rate beyond that with AT alone, but this benefit is accompanied by greater toxicity.
The difference in air pollutants in typical northern and southern CHINA coastal cities-Taking Shenzhen and Qingdao as examples
Authors: Chen Chunliang , Zhao Zike , Zhao Lirong , Yang Bo
Published: April 2022

In 2018, four air pollutants in Qingdao and Shenzhen were comprehensively analyzed and evaluated according to the standards. According to the results, PM2.5 exceeded its standard by multiples of 1.11 and 1.03 in January and February, respectively, in Shenzhen, and the no-exceedance probability was 84.6%. However, the no-exceedance probability in Qingdao was only 50%. When the maximun index of ambient air quality was used to evaluate the above pollutants, the air pollutant in Shenzhen was NO2 from May to September and PM2.5 in other the months, but the pollutants in Qingdao were different each month. The distribution patterns of the monthly average mass concentration of the pollutants in Shenzhen and Qingdao were consistent with the seasonal distribution. The particulate matter in the air was still the focus of the government in Shenzhen. The sources of air pollutants in Qingdao were diverse, and most pollutants were related to energy combustion.
Steel fibers from waste tires as reinforcements in concrete: Analysis of bond mechanism
Authors: Li Yan , Wang Xiao-Peng , Dong Wen-Yang , Shi Lan-Qing
Published: April 2022

This paper mainly studies the bond performance between a single recycled steel fiber and concrete, to attain the overall bond strength of recycled steel fibers reinforced concrete. By measuring the load displacement curve of the recycled steel fibers under pullout, we ascertain the maximum bonding stresses of the recycled steel fibers with different depths, angles and shapes while undergoing interfacial pull-out. At the same time, through observations and calculations, the failure phenomena of three stages and the changing trend of bond stresses of recycled steel fibers along the anchorage section are obtained. It is evidenced that the recycled steel fibers reinforced concrete has good interfacial bonding performance. Numerical simulation results of fiber pull-out process via the finite elements provide conditions for the analysis of bond strength of recycled steel fibers reinforced concrete cubes under different circumstances.
Study on equivalent fracture toughness of recycled steel fiber-reinforced concrete based on digital image correlation technology
Authors: Li Yan , Zhao Ronghua , Dong Wen-Yang , Chen Geng
Published: April 2022

Recycled steel fiber-reinforced concrete is a new hybrid high performance environmental protection composite material, which can be widely used in the construction industry and provide a new research direction for national green and sustainable development. In this study, three-point bending beams with a prefabricated incision were used to evaluate the fracture performance of plain concrete, steel fiber-reinforced concrete and recycled steel fiber-reinforced concrete with different fiber volume contents, fiber length-diameter ratios and relative incision depths based on digital image correlation technology. The results show that recycled steel fibers can improve the crack resistance of concrete beams better than ordinary steel fibers; The crack resistance of specimens increases with the increases of volume ratio of recycled steel fibers, and when the fiber content is from 0.0 % to 1.0 %, the increased amplitude of the crack resistance of specimens increases gradually, when the fiber content is from 0.5 % to 1.0 %, the increased amplitude of the crack resistance of specimens reaches the maximum, and when the fiber content is from 1.0 % to 1.5 %, the increased amplitude of the crack resistance of specimens decreases; The crack resistance of specimens increases with the increases of length-diameter ratio of recycled steel fibers, and when the fiber length-diameter ratio is from 30 to 50, the crack resistance of specimens increases relatively large, when the fiber length-diameter ratio is from 50 to 70, the crack resistance of specimens increases relatively small; The crack resistance of specimens decreases with the increases of relative incision depth of specimens, and when the relative incision depth is from 0.2 to 0.3, the crack resistance of specimens decreases relatively large, when the relative incision depth is from 0.3 to 0.4, the crack resistance of specimens decreases relatively small; The equivalent fracture toughness of concrete beams does not change with the changes in the relative incision depth. The simulated results correlated well with the experimental results, except some macroscopic phenomena during the cracking process. This study can provide references for the research of fracture behavior of steel fiber-reinforced concrete materials and the recycling of steel wire from waste tires.
Study on bonding compression-shear performance between industrial green fiber-reinforced concrete and old concrete
Authors: Li Yan , Zhao Ronghua , Dong Wen-Yang , Jiang Qi-Ren
Published: April 2022

Industrial green fiber-reinforced concrete, a new hybrid high performance environmental protection material, can be made by adding recycled steel fibers into concrete in a certain proportion. As a composite material used in the construction industry, it can provide a new research direction for national green and sustainable development. This paper studied the interface bonding mechanism of normal steel fiber-reinforced old and new concrete and industrial green fiber-reinforced concrete and old concrete by using a self-made new fixture, and discussed the influence of compressive stress, types of steel fibers and recycled steel fiber content on the bonding compression-shear performance of specimens. The results show that the bonding compression-shear performance of specimens gradually increases with the increases of the compressive stress acting perpendicular to the shearing surface within the range of low compressive stress, and when the compressive stress is from 0.2 MPa to 1.0 MPa, the increased amplitude of the bonding compression-shear performance of specimens gradually increases, when the compressive stress is from 0.6 MPa to 1.0 MPa, the increased amplitude of the bonding compression-shear performance of specimens reaches the maximum, and when the compressive stress is from 1.0 MPa to 1.4 MPa, the increased amplitude of the bonding compression-shear performance of specimens decreases. Under the same conditions, the effect of the recycled steel fibers on improving the bonding compression-shear performance between old and new concrete is better than normal steel fibers. The bonding compression-shear performance between old and new concrete gradually increases with the increases of the volume ratio of recycled steel fibers, and when the fiber content is from 0.0 % to 1.0 %, the increased amplitude of the bonding compression-shear performance of specimens gradually increases, when the fiber content is from 0.5 % to 1.0 %, the increased amplitude of the bonding compression-shear performance of specimens reaches the maximum, and when the fiber content is from 1.0 % to 1.5 %, the increased amplitude of bonding compression-shear performance of specimens decreases. The simulation results of industrial green fiber-reinforced concrete and old concrete specimens with fiber content of 1.5 % under different compressive stresses are basically in agreement with the experimental results. This study can provide references for the research of bonding compression-shear behavior of steel fiber-reinforced old and new concrete materials and the recycling of steel wire from waste tires.
Editorial Letter
Authors: Fan Hongkin
Published: April 2022

This special issue “Sustainable Architecture and Urban Environment” is published with selected research articles of the 2020 International Conference on Climate Change, Green Energy and Environmental Sustainability (CCGEES 2020) held in Haikou, Hainan Province, P.R. China during 18-20 December 2020. CCGEES 2020 aims to bring together scientists, engineers and scholars for sharing of their latest research findings and experiences in dealing with climate change, sustainable design and development in today’s fast changing world. The special issue covers a wide range of research topics dealt with in a multi-disciplinary and multi-dimensional approaches. Research areas include but not limited to: smart mobility, social innovation, sustainable and resilient buildings, social impacts and cities resiliency, energy transition, financing sustainability, energy efficiency, clean energy deployment, and ICT, smart grid and intelligent infrastructure. Sustainable design, sustainable development and sustainable urbanization is more crucial to a developing country like China. With rapid economic growth and urbanization, how to develop an economy without compromising the environment, how to create a built environment in harmony with the human beings and improve people’s living quality, have caught the attention of the Chinese governments at different levels, and research community at large. A variety of research topics are addressed in this special issue, such as the use of recycled building materials, user-friendly urban planning and design, water quality modelling, environmental information management, green building design, etc. The research findings and discussions are expected to advance the theory and practice in sustainable development. Thanks to the contributions of the au-thors who disseminate their top-notch research works to benefit the research community and policy makers in the field. The authors responded swiftly to the editor and publisher on their requests to make improvement to the manuscripts and address the questions from the reviewers with their best efforts. Special thanks are also extended to the managing editor Claudio M. Amescua García of the Revista Internacional de Contaminación Ambiental Journal, who dedicated tremendous efforts to the editing and publishing of the special issue with Professionalism.We wish the readers enjoy the reading of the rigorously selected research articles in the special issue and benefit from the research works presented by the authors.
Glucose Starvation or Pyruvate Dehydrogenase Activation Induce A Broad, ERK5-Mediated, Metabolic Remodeling Leading to Fatty Acid Oxidation
Authors: Khan Abrar Ul Haq , Salehi Hamideh , Alexia Catherine , Valdivielso José M. , Bozic Stanojevic Milica , López-Mejía Isabel Cristina , Fajas Lluis , Gerbal-Chaloin Sabine , Daujat-Chavanieu Martine , Gitenay Delphine , Villalba Martín
Published: April 2022

Cells have metabolic flexibility that allows them to adapt to changes in substrate availability. Two highly relevant metabolites are glucose and fatty acids (FA), and hence, glycolysis and fatty acid oxidation (FAO) are key metabolic pathways leading to energy production. Both pathways affect each other, and in the absence of one substrate, metabolic flexibility allows cells to maintain sufficient energy production. Here we show that glucose starvation or sustained pyruvate dehy-drogenase (PDH) activation by dichloroacetate (DCA) induce a large genetic remodeling to pro-pel FAO. The extracellular signal-regulated kinase 5 (ERK5) is a key effector of this multistep metabolic remodeling. First, there is an increase in the lipid transport by expression of low-density lipoprotein receptor-related proteins (LRP), e.g. CD36, LRP1 and others. Second, an increase of the expression of members of the acyl-CoA synthetase long-chain (ACSL) family acti-vates FA. Finally, the expression of the enzymes that catalyze the initial step in each cycle of FAO, i.e. the acyl-CoA dehydrogenases (ACADs), is induced. All of these pathways lead to enhanced cellular FAO. In summary, we show here that different families of enzymes, which are essential to perform FAO, are regulated by the signaling pathway, i.e. MEK5/ERK5, which transduces changes from the environment to genetic adaptations.
Resolution of the Council of Experts “Dysbiosis. Immediate and long-term consequences of microbiome disorders and options for their correction with probiotics”
Authors: Gorelov A.V. , Zakharova I.N. , Khavkin A.I. , Kafarskaya L.I. , Usenko D.V. , Belmer S.V. , Kornienko E.A. , Privorotsky V.F. , Krasnov V.V. , Kondyurina E.G. , Panfilova V.N. , Tkhakushinova N.Kh. , Plaksina A.N. , Rychkova O.A. , Pechkurov D.V. , Nizhevich A.A. , Fayzullina R.A. , Yablokova E.A.
Published: April 2022

The appearance of new high-tech microbiological research methods has significantly changed the understanding of the human microbiome. The purpose of the meeting of the Council of Experts "Dysbiosis. The immediate and long-term consequences of microbiome disorders and options for their correction with probiotics" was the definition of modern positions about possible methods of studying the intestinal microbiome, the possibilities of correcting dysbiosis, the use of Saccharomyces Boulardii CNCM I-745 to correct microbiome disorders in various clinical situations. The microbiota of the large intestine is represented by more than 1000 species of 7 different phyla of the Bacteriae domain, up to 160 numerically prevailing species are detected in one individual. The criteria of the microbiological "norm" for the intestinal microbiome have not been definitively established. To study the microbiome, a set of methods is used that combine cultural and molecular genetic methods that complement each other. Currently, none of the methods is widely available in clinical practice. To study the functional state of the intestinal microbiota, the most accessible is breath testing. Currently, there are no clinical markers of dysbiosis, and laboratory markers of dysbiosis require modification. There is an insignificant spectrum of diseases with such markers: acute intestinal infections, antibiotic-associated C. difficile-diarrhea, IBD, IBS. Probiotics can provide restoration of the intestinal microbiota. The effectiveness and safety of the use of S. boulardii CNCM I-745 for this purpose has been proven. In the case of acute intestinal infection, antibiotic-associated diarrhea, and the consequences of HP infection eradication, studies have a high level of evidence, and the use of Sb CNCM I-745 for treating IBS and IBD in children is promising.
Repositorio de Software Educativo: Una aproximación de desarrollo conceptual
Authors: Rodríguez-Aguilar Verónica , Canchola Magdaleno Sandra Luz , Muñoz Andrade Estela Lizbeth , Garzón Clemente Rebeca
Published: April 2022

La conceptualización sobre los repositorios se ha diversificado ampliamente con base en su aplicación contextual y disciplinar. En esta diversificación no se precisa una definición específica para los Repositorios de Software Educativo (RSE). El objetivo de esta investigación documental fue desarrollar  un concepto que permitiera especificar que es un RSE. Se aplicó el método de Cartografía Conceptual que es un procedimiento de análisis crítico en cuatro fases: 1) Búsqueda de documentos pertinentes al problema; b) Definición de los criterios de inclusión y exclusión de documentos; 3) Análisis de datos con 8 categorías: desarrollo histórico, noción, categorización, clasificación, diferenciación, ejemplificación, teorización y caracterización; 4) Interpretación de los resultados bajo la perspectiva educativa del software. Los resultados muestran 11 tipos de repositorios: Digital, Institucional, Agregador, Temático, de Material Educativo Digital, de Documentos Administrativos, de Objetos de Aprendizaje, de Componentes de Software y/o de Activos de Software, Nacionales y los de Datos. El hallazgo más importante sugiere que, un RSE es un repositorio digital, institucional y temático, de acceso abierto y aplicación interdisciplinar que almacena procesos de ingeniería para el desarrollo de software ágil, componentes o activos, empleados en la construcción de recursos educativos y objetos de aprendizaje del área pedagógica específicamente.
The role of miRNA-424 in various cancers: Focusing on drug resistance and sensitivity
Authors: Najafi Fatemeh , Kelaye Shohre Karimi , Kazemi Bahareh , Foruzandeh Zahra , Allahverdizadeh Farahnaz , Vakili Sajjad , Seif Farhad , Derakhshani Mahdi , Solali Saeed , Alivand Mohammad Reza
Published: April 2022

Background
However, advanced technologies have been developed in the treatment of various cancers, but the mortality rate from cancer is still very high. Drug resistance is a major problem for patients with cancer, which causes the treatment process to fail. In addition to inhibiting drug resistance, targeted therapy is also very important in treatment.
Main body:
Nowadays, miRNAs have gained increasing interest as they play a major role in both drug resistance and targeted therapy. MicroRNA (miRNA) is an important part of non-coding RNA that regulates gene expression at a post-transcriptional level. The prevailing studies about miRNA expression have been expanded into a variety of neoplasms. MiR-424 targets genes involved in various cellular processes and can participate in proliferation, differentiation, apoptosis, invasion, angiogenesis, and drug resistance and sensitivity.
Conclusion
In this study, we focus on the role of miR-424s in many cancer types by displaying the potential target genes associated with each cancer, as well as briefly describing the clinical uses of miR-424s as a diagnostic and predictive tool in malignancies.
Performance analysis of Cu/CNT based TSV: Impact on Crosstalk and Power
Authors: Chandrakar Shivangi , Gupta Deepika , Majumder Manoj Kumar
Published: April 2022

This paper presents the first realistic and holistic approach to exhibit compact resistance–inductance–capacitance–conductance (RLCG) model for (Carbon nanotube) CNT and Cu based different shaped through-silicon vias (TSVs) in 3-D ICs. The model primarily comprises the effect of bump, inter-metal dielectric, and eddy currents. Using the proposed model, a mathematical formulation for the coaxial, cylindrical, and tapered based via parasitics are derived using the concept of partial inductance, sectioning via laterally into infinitesimally thin slices and triangular inter-tube assemblage, respectively. The analytical model is validated against a fabrication based experimental results and subsequently employed for crosstalk induced delay, peak noise, and power losses analysis. Additionally, for the further validation, the S parameter for the Pi-based model is derived, and compared with an electromagnetic simulator to benchmark the proposed model. The tremendous consistency between the analytical and EM simulation based results further evidences the validity of the proposed model. Encouragingly, a significant improvement in the power losses, crosstalk, and peak noise can be observed using the CNT-based tapered TSV compared to the Cu-based via structures. Additionally, it is shown that the irrespective of via height, the average crosstalk induced delay, peak noise, signal transmission, and reflection loss of the TSV with tapered shaped 15-shell CNT bundle is reduced by 22.82%, 27.80%, 47.63%, and 33.71%, respectively compared to the Cu.
The Development and Validation of the Japanese version of Job Satisfaction Scale: A Cross-sectional Study on home healthcare nurses.
Authors: Mori Yoko , Sasaki Miki , Ogata Yasuko , Togari Taisuke
Published: April 2022

Objective: A reliable and valid tool is required to assess home healthcare nurses’ job satisfaction for evaluating and improving the work environment and clinical practice of home healthcare. This study aimed to develop and examine the Japanese version of the Home Healthcare Nurses’ Job Satisfaction Scale (HHNJS-J). The Home Healthcare Nurses’ Job Satisfaction Scale (HHNJS) was translated into Japanese; a backward translation was performed until equivalence between the original and the backward-translated HHNJS was confirmed. Subsequently, a mail survey was conducted among 409 home healthcare nurses from 154 home healthcare agencies in Japan. We evaluated construct validity through Confirmatory Factor Analysis (CFA), and criterion-related validity and internal consistency were also tested.Results: The CFA revealed a second-order seven-factor structure and adequate internal consistency, although, the fit of the data to the factor structure was moderate. As per the goodness-of-fit indices of the final model of the CFA, the comparative fit index was 0.89 and root mean square error of approximation was 0.06. This newly translated scale can be used to assess the job satisfaction of home healthcare nurses within Japan. The HHNJS-J evaluated acceptable reliability and validity among Japanese home healthcare nurses and had application in clinical practice in Japan.
A Survey on the Use and Resistance of Antibiotics in Maharashtra
Authors: DAS S K , BHILEGAONKAR K N , Aithal H P
Published: April 2022

Livestock is an important integral part to the sustainability of economy of this state. Antibiotic resistance is worldwide very common problem. The current study aimed to assess the knowledge, attitude, and practices pertaining to antibiotic usage among the field veterinarians.Feedback of 291 veterinary officers of Maharashtra state was taken regarding the use and resistance of different types of antibiotics in supplied format. It was revealed that ampicillin and amoxicillin in “Penicillin group”, oxytetracycline in “Tetracycline group”, cefotaxime and ceftriaxone in “Cephalosporine group”, enrofloxacine in “Quinolones group”, gentamycin in “Amynoglycosides group”,erythromycin in “Macrolides”group and Ampicillin &Cloxacillinin “Combination group” was used mostly due to their efficacy.The most important reason for using the antibiotics was found to be “effectiveness of antibiotic” (4.36 ± 0.08).It was indicated that in “bacterial infection” (4.62 ± 0.07) antibiotic was used mostly. Most important reason for antibiotic resistance was found to be “indiscriminate use of antibioticsby owners / paravets” (4.45 ± 0.08).The most important measure for prevention of antibiotic resistance was observed to be “ensuring proper dose and duration of treatment of antibiotics” (4.46 ± 0.08).
Multimodal Detection of Hateful Memes by Applying a Vision-Language Pre-Training Model
Authors: Chen Yuyang , Pan Feng
Published: April 2022

Detrimental to individuals and society, online hateful messages have recently become a major social issue. Among them, one new type of hateful message, named “hateful meme”, has emerged and brought difficulties in traditional deep learning-based detection. Because hateful memes were formatted with both text and image to express users’ intents, they cannot be accurately identified by singularly analyzing embedded text or images. In order to effectively detect a hateful meme, the algorithm must possess strong vision and language fusion capability. In this study, we move closer to this goal by feeding a triplet by stacking the visual features, object tags, and textual features of memes generated by the object detection model VinVL and the optical character recognition (OCR) technology into a Transformer-based Vision-Language Pre-Training model OSCAR+ to perform the cross-modal learning of memes. After fine-tuning and connecting to a random forest classifier (RF), our model (OSCAR+RF) achieved a 0.768 AUROC score on the hateful meme detection task in a public dataset, which was higher than the published baselines. In conclusion, this study has demonstrated that Vision-Language PTMs with the addition of anchor points can improve the performance of deep learning-based detection of hateful memes by involving a more substantial alignment between the textual and visual information.
Maternal Mental Health and Breastfeeding amidst the Covid-19 Pandemic: outcomes in a Catalan cohort
Authors: Nicolás-López Marta , González-Álvarez Pablo , Sala-Concepción Anna , Giralt-López Maria , Lorente Beatriz , Velasco Inés , Wichner Paula Sol Ventura , Ginovart Gemma
Published: April 2022

Background: Covid-19 pandemic became an unexpected stressor for the entire population and, particularly, for pregnant women and lactating mothers. The alarming infectious risk together with the lockdown period could affect the emotional state of mothers-to-be, as well as breastfeeding rates, mother-baby bonding, or neonatal weight gain. The aim of this study is to describe the impact of this world health emergency in mother-baby pairs right after the first wave of Sars-Cov-2 pandemic (from March to May 2020). Study design: a prospective observational study was carried out in mother-child dyads from those women who gave birth between June and August 2020 in a tertiary hospital. 91 mother-baby pairs were initially enrolled and 56 of them completed the follow-up. The study design had two separate steps: i) Step one: A clinical interview plus three psychometric tests (EPDS: Edinburgh Postnatal Depression Scale, PBQ: Postpartum Bonding Questionnaire and STAI-S: State-Trait Anxiety Inventory); ii) Step two: mother-child dyads were followed using a round of three brief telephone interviews (conducted at the newborn’s 7, 14 and 28 days of age) to accurately depict the newborn’s outcome in the neonatal period. Results: In terms of maternal mental health, 25% of the sample screens positively in the EPDS, requiring further evaluation to rule out depressive symptoms. STAI-state and PBQ detect no abnormalities in either anxiety levels or mother-child bonding in our sample, as 100% of the mothers score below the cut-off points in each test (34 and 26 respectively). When comparing feeding practices (breast/bottle feeding) in 2020 to those practices during pre-pandemic years (2017-2019), a significant increase in breastfeeding was found in pandemic times. All newborns in the sample showed an adequate weight gain during their first month of life. Conclusion: Women and newborns in our sample did not experience an increase in adverse outcomes in the neonatal period in terms of maternal mental health, breastfeeding rates, bonding and further neonatal development.