bluuebunny/crossref_metadata_2025 huggingface dataset:
Mycovirus-Containing Aspergillus flavus as an Etiologic Factor for Acute Leukemias in Genetically Susceptible Individuals
Authors: Tebbi Cameron , Sahakian Eva , Shah Bijal , Yan Jiyu , Mediavilla-Varela Melanie , Patel Saumil
Published: January 2025

Several etiologic factors for the development of acute leukemias have been suggested, however, none is applicable to all cases. We have isolated a certain mycovirus-containing Aspergillus flavus (MCAF) from the home of a patient with acute lymphoblastic leukemia. Repeated electron microscopic evaluations proved the existence of mycovirus in this organism. By chemical analysis, this organism does not produce any aflatoxin, which may be due to its infestation with mycoviruses. We have reported that using the ELISA technique, forty pediatric patients with acute lymphoblastic leukemia (ALL) uniformly had antibodies to the products of MCAF. In contrast, three separate groups of controls, consisting of normal blood donors, individuals with solid tumors, and patients with sickle cell disease, were negative. In vitro exposure of mononuclear blood cells from patients with ALL, in full remission, to the products of MCAF induced redevelopment of cell surface phenotypes and genetic markers characteristic of ALL. Controls were negative. Incubation of normal and ALL cell lines with the products of MCAF resulted in significant cellular apoptosis, changes in the cell cycle, and downregulation of transcription factors, including PAX-5 and Ikaros (75 and 55 kDa). Fungi are widespread in nature, and many contain mycoviruses. Normally, an individual inhales 1 to 10 fungal spores per minute, while farmers can inhale up to 75000 spores per minute. It is known that farmers and foresters, who are more exposed to fungi, have a higher rate of acute leukemia. In contrast, asthmatics, most of whom are allergic to fungal agents, and individuals working in office settings have a lower rate. One of the theories for the development of acute leukemia suggests a genetic predisposition followed by exposure to an infectious agent. With the above findings, we propose that mycovirus-containing Aspergillus flavus may have an etiological role in leukemogenesis in immune-depressed and genetically susceptible individuals.
A Gis-Based Decision Support Model (DSM) for Harvesting System Selection on Steep Terrain: Integrating Operational and Silvicultural Criteria
Authors: Eberhard Benno , Trailović Zoran , Magagnotti Natascia , Spinelli Raffaele
Published: January 2025

The objective of this study is to create a GIS-based decision support model for steep terrain timber harvesting. The tool integrates multiple raster layers, each representing a critical aspect of mechanized timber harvesting, and uses them to generate a composite map that aids in decision-making about suitable areas for specific machine configurations. The innovation lies in two pivotal aspects: first, the tool integrates silvicultural considerations alongside operational criteria; second, it employs a new methodology that factors in these silvicultural criteria without depending on resource-intensive point cloud data. Instead, the methodology integrates aerial imagery in the form of an orthofoto, and the deep-learning algorithm DeepForest for the evaluation of forest stand characteristics. The procedure was tested in South Tyrol, Italy, using remotely sensed data and validated against ground-based inventory data. While the results indicate an underestimation of stem numbers and a tendency to underrate small tree dimensions, overall performance statistics are promising. This makes the procedure a valuable tool for forest management planning, effectively integrating operational and silvicultural considerations.
Integrating P2M-CC for Sustainable Decarbonization in Cement Manufacturing
Authors: Dinca Cristian Florian , Slavu Nela
Published: January 2025

The cement industry is recognized as an energy-intensive industry, and as a consequence of this, it is one of the industries that generate large amounts of CO2 into the environment. The global fight against climate change requires rethinking processes in such industries. The use of fossil fuels as a primary energy source and the cement production process make it one of the industries with the largest CO2 footprint. In this case, a sustainable solution, at least in the medium term, is to integrate the P2M-CC (Power - to - methane with carbon capture) concept, which involves replacing natural gas with synthetic methane obtained by methanization of green hydrogen and carbon dioxide captured from the industrial process. The paper analyzed three modernization scenarios of a cement plant with an annual production of 1,200,000 tons defined on the basis of techno-economic assumptions. It was observed that by integrating the P2M-CC concept in the initial process, the CO2 emission factor decreased from 789 (baseline scenario) to about 85 kg/ton of cement (proposed scenarios). From an economic point of view, the initial investment costs were significantly higher in the proposed scenarios than in the reference case due to the expansion of the plant by including electrolysis, methane, CO2 capture, and wind farm energy production. The costs were thus 5 to 13 times (€ 2.9 billion) higher than in the baseline scenario according to the assumptions underlying each scenario. In terms of operation and maintenance costs, the variation was totally different depending on the scenario analyzed, ranging from less than half of the costs of the baseline scenario to 2.4 times (€ 2.8 billion) higher. This variation depended to a large extent on the CO2 tax and the excess electricity used in the clinker process. The discounted cost per tonne of cement, LCOC, varied significantly for the 3 proposed scenarios, with the minimum value (about 58% lower than in the reference case) being obtained for the ideal scenario where the excess electricity covers the entire electricity needs of the cement plant processes. Despite the much higher initial investment and operating costs, the payback period was slightly longer than in the baseline case (5 vs. 3 years) due to the significantly higher net fees paid in the baseline scenario. In conclusion, the technical and economic improvement of the performance of the cement industry is dependent on the EU-wide regulation of CO2 taxes but also on the careful management of electricity generated by renewable energy sources.
Near Real-Time 3D Reconstruction of Construction Sites Based on Surveillance Cameras
Authors: Sun Aoran , An Xuehui , Li Pengfei , Lv Miao , Liu Wenzhe
Published: January 2025

The 3D reconstruction of construction sites is of great importance for construction pro-gress, quality, and safety management. Currently, most of the existing 3D reconstruction methods are unable to conduct continuous and uninterrupted perception, and difficult to achieve registration with real coordinates and dimensions. This study proposes a hierar-chical registration framework for 3D reconstruction of construction sites based on surveil-lance cameras. This method can quickly perform on-site 3D reconstruction and restoration by taking fixed views such as surveillance camera images as inputs without transfer learning and camera calibration. This framework can complete the 3D point cloud esti-mation and registration of construction sites within an average of 3.105s through surveil-lance images. The average RMSE of the point cloud within the site is 0.358m, which is better than most point cloud registration methods. Through this method, 3D data within the scope of surveillance cameras can be quickly obtained, and the connection between 2D and 3D can be effectively established. Combined with visual information, it is beneficial to the digital twin management of construction sites.
Parental Factors Associated With Measles–Mumps–Rubella Vaccination in US Children Younger Than 5 Years
Authors: Zhou Eric Geng , Cantor Jonathan , Gertz Autumn , Elbel Brian , Brownstein John S. , Rader Benjamin
Published: January 2025

Objectives. To determine the association between parental characteristics and MMR (measles–mumps– rubella) vaccination status of children in the United States.

Methods. We conducted a cross-sectional study from July 2023 to April 2024 using a digital health survey via OutbreaksNearMe, weighted to target national population characteristics. We analyzed the responses of 19 892 parents of children younger than 5 years to examine the association between self-reported parental characteristics (i.e., sociodemographics, politics, COVID-19 vaccination status) and children’s MMR vaccination rates using logistic regression.

Results. Children of parents who received at least 1 dose of the COVID-19 vaccine had higher MMR vaccination rates (80.8%) than did children of unvaccinated parents (60.9%; odds ratio [OR] = 1.84; 95% confidence interval [CI] = 1.68, 2.00). We observed lower MMR vaccination rates among children of parents who identified as Republican versus Democratic (OR = 0.73; 95% CI = 0.64, 0.82), parents on Medicaid or Medicare versus private insurance (OR = 0.85; 95% CI = 0.76, 0.95), and minority (OR = 0.44) versus White (OR = 0.71) parents. We found higher MMR vaccination rates in the Northeast and Midwest United States.

Conclusions. Early data indicate that parental sociodemographic characteristics and COVID-19 vaccine status are associated with children’s MMR vaccine uptake, emphasizing the need for further investigations into multipronged public health interventions. ( Am J Public Health. 2025;115(3):369–373. https://doi.org/10.2105/AJPH.2024.307912 )
IMPLEMENTASI ALGORITMA CHEAPEST INSERTION HEURISTICS BERBASISKAN ANDROID DAN GOOGLE MAPS PADA PT.XYZ
Authors: Khadafi Shah , Saputri Ovilia Rosa
Published: January 2025

Pada sebuah perusahaan eksedisi seorang kurir diperlukan aktivitasnya untuk mendukung kegiatan operasional perusahaan, terutama ketika seorang kurir mengantar pengiriman paket ke alamat tujuan yang sesuai. PT.XYZ adalah sebuah perusahaan ekspedisi dengan area kerja sekitar kota Surabaya dan sekitarnya. Permasalahan yang dihadapi oleh perusahaan tersebut, adalah beberapa kurirnya belum memahami dan mengetehui beberapa area dan jalan yang ada di kota Surabaya. Fokus penelitian ini pada topik Travelling Salesman Problem (TSP) yang bertujuan membentuk rute pengiriman yang tercepat dan efisien bagi kurir, yang nantinya bisa menjadi panduan bagi kurir yang kesulitan menemukan rute alamat paket pengirimannya, sehingga. mampu memberikan solusi dalam penentuan rute dengan jarak total paling minimum. Metode yang digunakan dalam pembuatan sistem ini yaitu Heuristic dengan algoritma Cheapest Insertion Heuristic (CIH). Hasil perhitungan algoritma CIH memanfaatkan Google maps sebagai rute yang telah terbentuk dan dapat dijadikan panduan bagi kurir. Pengujian sistem yang dilakukan terhadap tiga kurir terhadap efisiensi jarak tempuh dengan menggunakan CIH yaitu, kurir 1 efiisiensi yang dihasilkan sebesar 34,2 %, kurir 2 dengan efisiensi sebesar 28 %, dan kurir 3 efisiensi sebesar 21,31 %. Sedangkan total keseluruhan efisiensi yang dihasilkan oleh system ini sebesar 83,51%.Kata kunci: Cheapest Insertion Heuristic, Heuristic, Kurir, Traveling Salesman Problem
ANALISA PERBANDINGAN PERFORMA OPTIMIZER ADAM, SGD, DAN RMSPROP PADA MODEL H5
Authors: Anggara Doni , Suarna Nana , Arie Wijaya Yudhistira
Published: January 2025

Melakukan komunikasi tidak sebatas berbentuk verbal saja, bisa juga berkomunikasi nonverbal yaitu dengan menyampaikan informasi dari ekspresi wajah. Namun, permasalahan dalam analisa ekspresi wajah jika melakukan pendeteksian ekspresi wajah secara manual maka akan membutuhkan waktu yang cukup lama dan tidak selalu akurat, sedangkan jika melakukan pendeteksian menggunakan machine learning berbasis Python maka akan mempersingkat proses pendeteksian ekspresi wajah, oleh karena itu diperlukan suatu model yang memiliki tingkat accuracy yang mumpuni sehingga dapat mendeteksi dan mengklasifikasikan ekspresi wajah dengan cepat dan akurat. Tujuan utama dari penelitian ini yaitu untuk mengetahui optimizer mana yang terbaik diantara Adam, SGD, dan RMSprop untuk model klasifikasi dengan membandingkan performa hasil training dari setiap optimizer dimana hasil dari proses training menghasilkan file model dengan ekstensi h5. Model dengan metrik accuracy, validation accuracy, loss, waktu tempuh, dan size model terbaik di antara optimizer tersebut akan di nyatakan sebagai optimizer terbaik. Data yang digunakan berupa foto sebanyak 71.774 foto dengan 7 label ekspresi wajah yang diantaranya senang, sedih, terkejut, marah, takut, jijik, dan netral. Metode yang digunakan untuk mengukur performa model pada dataset yang diberikan yaitu evaluate() dari library Keras, classification_report dan precision_recall_fscore_support yang terdapat pada library sklearn.metrics. Dengan skenario pengujian 60 epochs dan learning rate sebesar 0.001, Optimizer Adam memiliki nilai accuracy lebih tinggi yaitu 68.61% disusul oleh SGD dengan nilai accuracy sebesar 57.68% dan accuracy RMSprop sebesar 54.83%.Kata kunci: Adam, Deep learning, Ekspresi Wajah, Klasifikasi, Optimizer, RMSprop, SGD.
PENERAPAN ALGORITMA LINEAR SEARCH DI APLIKASI SECONDHAND
Authors: Agustin Nely Dwi , Cobantoro Adi Fajaryanto , Setyawan Mohammad Bhanu , Nurfitri Khoiru
Published: January 2025

Inflation in Indonesia has been increasing year by year. The high inflation rate has an impact on the increasing production costs of finished goods, resulting in higher prices which this is not balanced by good sales of new products. This has led to a plan to create a secondhand e-commerce platform. This research aims to implement a search feature that facilitates the search for used goods based on keywords. The implementation process involves the use of the Linear/Sequential Search algorithm in the JavaScript programming language and PostgreSQL as the data storage used. In practice, when the keyword matches the data in the database, the search results will be displayed. If there is no data match, the search will not find any relevant products. The result of this research is the availability of the SecondHand application, with a search feature using the Linear/Sequential Search algorithm, which helps facilitate the interaction between sellers and buyers. The results of white box and postman/grey box testing show that the search feature and its functions work well, producing valid outputs, and have a short execution time of around 613.5 ms or 0.6135 seconds based on the results of five tests.Keywords : Linear/Sequential Search Algorithm, Used Goods, SecondHand.
KOMPARASI SVM KLASIK DAN KUANTUM DALAM KLASIFIKASI BINER BIJI GANDUM (SEEDS)
Authors: Akrom Muhamad
Published: January 2025

Binary classification is one of the important tasks in machine learning, with wide applications in various fields, including agriculture and food processing. This study compares the performance of the classical Support Vector Machine (SVM) and Quantum Support Vector Machine (QSVM) in wheat grain classification, focusing on accuracy, precision, recall, F1-score, and Area Under the Curve (AUC). The wheat grain dataset consists of physical features relevant to distinguish between two types of grains. The analysis results show that QSVM significantly outperforms classical SVM in all measured metrics, with higher accuracy and a better balance between precision and recall. The superiority of QSVM can be attributed to its ability to handle complex feature interactions and accelerate the training process through quantum algorithms. These findings demonstrate the potential of QSVM as a more effective model for binary classification applications. However, factors such as implementation complexity and availability of quantum computing resources need to be considered. This study provides valuable insights for the development of more efficient classification methods in the context of agriculture and other related fields.Keywords: Quantum Machine Learning, Quantum Support Vector Machine, Classification, Seeds
PENGGUNAAN METODOLOGI SCRUM DENGAN PENDEKATAN GOAL-ORIENTED REQUIREMENT ENGINEERING DALAM PENGEMBANG SISTEM INFORMASI KESEHATAN
Authors: Trinanda Muhammad Satria Putra , Irawati Irawati , Hasnawi Mardiyyah
Published: January 2025

The information obtained by the public is inadequate, and sometimes they still really need complete information, one of which is about diseases. The provision of media information must be proven accurate and should not be reported by organizations that do not have authority. In this case, health foundations have the right to provide information that is trusted for its authenticity, especially in providing information data regarding tuberculosis disease. The purpose of this research is to develop a tuberculosis tuberculosis information system on the Yamali TB platform with the Goal-Oriented Requirement Engineering (GORE) approach and the Scrum method. Information system development is carried out through several main activities, namely Problem Identification, Problem Analysis, Goal Identification, Backlog Prioritization, System Design, Initial Discussion, Program Design and Final Evaluation using the System Usability Scale assessment method. The results showed that the level of user satisfaction with the information system based on the usability test obtained an average of 77 and was ranked at Grade Scale C, Acceptability Ranges at the Acceptable level, and Adjective Ratings at the Good level which means that the information system developed is well received by users.Keywords: Goal-Oriented Requirement Engineering, Grade Scale, Scrum, System Usability Scale.
MULTI-CRITERIA RECOMMENDER SYSTEM BERBASIS METODE WEIGHTED SUM DAN PARETO FRONT UNTUK MANAJEMEN SUMBER DAYA AIR
Authors: Putri Astrid Novita
Published: January 2025

AbstractClean water is used daily to meet individual needs such as cooking, drinking, bathing, and more. Clean water is essential to support human metabolism, which impacts health. However, obtaining clean water has become increasingly difficult due to high population growth and rising demand, coupled with limited availability.This study develops a multi-criteria recommender system model that considers various criteria or attributes to provide valuable recommendations, facilitating better decision-making based on suitable recommendations regarding water production and consumption. Using the Pareto front and weighted sum methods, this model balances trade-offs among criteria. The results of this study offer an optimal solution for both consumers and water resource management in Semarang City to achieve balance, with W1 minimizing water consumption and W2 maximizing production. The recommended optimal solution is W1 = 0.5 and W2 = 0.5, yielding water consumption of 1,064,910.4 m³/ha and production yield of 14,933,601 tons/ha. Other findings include W1 = 0.1 and W2 = 0.9, yielding water consumption of 11,115,920 m³/ha and production yield of 16,341,636 tons/ha. W1 = 0.4 and W2 = 0.6, yielding water consumption of 11,115,920 m³/ha and production yield of 16,341,636 tons/ha, W1 = 0.7 and W2 = 0.3, yielding water consumption of 10,649,104 m³/ha and production yield of 14,933,601 tons/ha.These outcomes indicate optimal solutions based on different weighting balances between consumption and production criteria.Keywords: Multi-criteria recommender system, pareto front, water resource management
Institución eduactiva ecoeficiente en la Nueva Rinconada: "Evaluación del nivel de ecoeficiencia en relación al impacto ambiental y educación ambiental en las instituciones educativas de Nueva Rinconada, San Juan de Miraflores, 2021
Authors:   , Balaguer Vasquez Olenka , Jauregui Rivera Greyton
Published: January 2025

En el año 2011 el Ministerio de Educación en alianza con el Ministerio del Ambiente proponen la iniciativa de incluir la ecoeficiencia en instituciones educativas, llamada ecolegios, planteando a estas instituciones una educación ambiental con enfoque en ecoeficiencia. (MINAM 2020). Esta propuesta no se ha aplicado. Un ejemplo de esto, son las instituciones educativas que se encuentran en la zona de Nueva Rinconada (La Rinconada 7221 y Fe y Alegría N°65). Por lo tanto, se plantea como objetivo principal, diseñar una nueva institución educativa ecoeficiente que cubra la brecha de calidad existente en el servicio de educación inicial, primaria y secundaria en la Zona de Nueva Rinconada - Pamplona Alta, distrito de San Juan de Miraflores; para llegar a este objetivo se emplearon como metodología fichas de observación y entrevistas a las que se tuvo como resultado principal una brecha significativa en la educación ambiental en las instituciones educativas de la zona.
Por lo tanto, se ha diseñado una institución educativa ecoeficiente en Nueva Rinconada, en la que se cierra la brecha de educación ambiental y ecoeficiencia en las instituciones educativas en la zona.
Influencia de la gestión de recursos humanos internacionales en la competitividad empresarial de una multinacional del rubro textil (Lima-Perú), 2024
Authors:   , Granados Retiz Silvana Jakeline
Published: January 2025

Inmersos en el actual panorama empresarial, signado por una profunda globalización y un entorno progresivamente más competitivo, la gestión estratégica de los recursos humanos a escala internacional y el fortalecimiento de la competitividad organizacional han adquirido una relevancia sin precedentes, convirtiéndose en factores decisivos para el éxito y la sostenibilidad de las empresas multinacionales en el siglo XXI. Es en este marco que el estudio tuvo como objetivo general analizar la influencia de la gestión de recursos humanos internacionales sobre la competitividad empresarial de una multinacional textil. La investigación se llevó a cabo bajo un diseño no experimental, transeccional y correlacional-causal, con un enfoque cuantitativo en su implementación. La muestra de la pesquisa estuvo conformada por 26 colaboradores pertenecientes al Área de Comercialización de la empresa textil. Como resultado del análisis, se pudo concluir que la gestión de recursos humanos internacionales ejerce una influencia directa y significativa sobre la competitividad empresarial de esta multinacional textil; estos hallazgos se encuentran respaldados por la relación causal establecida, la cual se evidencia a través del coeficiente de Nagelkerke de 0.709 (70.9%), validando así la hipótesis alterna que sostiene la influencia directa y significativa de una variable sobre la otra.
Emerging trends and hot spots in epigenetic modifications in neurology: A bibliometric analysis
Authors: Xu Shu-Ying , Zhang Siyao , Zeng Chun-Li , Peng Yong-Jun , Xu Min
Published: January 2025

This study employs a bibliometric analysis to examine the evolution and future trajectories in epigenetic modifications in neurology from 2004 to 2024. A total of 12,964 publications were scrutinized via the R bibliometrix package and VOSviewer for network visualization, complemented by Scimagp Graphica to elucidate global collaborative networks. Our extensive review reveals a significant growth in the field of epigenetic neurology studies, driven by an increased output of publications and evidenced by an enhanced focus on epigenetic modifications. The United States and McGill University are recognized as central contributors, with Nature leading as the most prolific journal and J. Mill and E.J. Nestler distinguishing themselves as key authors by publication volume and citation impact, respectively. A detailed keyword analysis highlighted "expression," "DNA methylation," "brain," "gene-expression," and "gene" as the most recurrent terms, indicating core areas of research concentration. Subsequent manual analysis due to software-detected inaccuracies reaffirmed Alzheimer's disease, cancer, and schizophrenia as predominant neurological diseases associated with epigenetic studies. Pathophysiological processes such as DNA methylation, oxidative stress, and synaptic plasticity have been extensively examined in relation to epigenetic modifications in neurology. Synthesis of the reference literature analysis identifies critical themes such as the role of glucocorticoid receptors, the significance of hydroxymethylcytosine in neural DNA, the implications of epigenetic patterns in mental health, and the impact of BDNF gene on memory consolidation. These insights into epigenetic research in neurology indicate a sustained and intensifying trajectory, hinting at expanding horizons for future therapeutic approaches and interventions. Our findings underscore an active and progressing interest in neurological epigenetics, suggesting a continued expansion and specialization in the exploration of epigenetic mechanisms and their clinical relevance.
An ‘Invisible Nerve’ To Block: A Regional Anaesthesia Block Conundrum of Sciatic Nerve for Above-Knee Amputation in A High-Risk Patient
Authors: Baththirange Malaka Munasinghe , Jayasuriya NJASS
Published: January 2025

Background
Above-knee amputation (AKA) under regional anaesthesia alone can pose multiple challenges to anaesthetists. For AKA, ultrasound-guided selective sciatic nerve, posterior femoral cutaneous nerve (PFCN), femoral, lateral femoral cutaneous, and obturator nerve blockade provide satisfactory anaesthesia.
Case Presentation
A 52-year-old woman with ischemic heart disease, atrial fibrillation on therapeutic anticoagulation, chronic kidney disease stage 3, poorly controlled diabetes mellitus, anaemia, and heart failure (ejection fraction 25–30%) was scheduled for an urgent left AKA under regional anaesthesia block due to ascending infection. Considering the high risk, a suprainguinal fascia iliaca block with a perineural catheter was performed under ultrasound. Visualisation of the sciatic nerve and the PFCN was unsuccessful as the neurosonoanatomy was undetectable. The motor response using a nerve stimulator to the suspected sciatic nerve failed, too. 0.5% levobupivacaine 20ml was administered in the area of the suspected nerves using piriformis and other sonoanatomical landmarks. Amputation was carried out without additional analgesia or sedation. Intraoperatively, the sciatic nerve was found to be distorted macroscopically due to liquefactive necrosis. Postoperatively in HDU, her pain control was satisfactory with perineural infusion.
Conclusions
The inability to identify the sciatic nerve due to liquefaction is a peculiar encounter in this patient. Still, it hints at an unusual cause for difficult peripheral nerve visualisation and stimulation. Due to the fact that the sciatic and PFCN lie closer when they exit the sciatic foramen under piriformis, a sufficient volume of local anaesthetic during sciatic nerve block may spread around and anaesthetise PFCN.
Production objectives of smallholder farmers: Implications on beef value chain in livestock development programmes
Authors: Muteyo Enock , Gift Chomuzinda
Published: January 2025

In this current context of production objectives which has shifted from pro commercial to one that is largely dominated by the small to medium cattle producers a case study in beef agro- ecological zones was conducted in Gokwe South and Mount Darwin, two administrative districts in Zimbabwe, to assess its effectiveness in beef value chain (BVC) in livestock development programmes. A total of 100 respondents were randomly drawn from the two districts three villages from Gokwe South and six from Mount Darwin. A structured questionnaire was developed and pretested to ensure that the questions were properly developed and structured. The tool was uploaded on Kobo, a data collection Kit and administered by well-trained enumerators. Key modules of the collected Data included biodata, profiling production systems, objectives of keeping animals, constraints in the production systems, marketing practices, herd dynamics and adaptive mechanism. Data was analyzed by SPSS version 23. The findings showed that smallholder beef farmers in the surveyed districts practice subsistence farming prioritized keeping cattle for draught power, and as a moving bank which also has a positive bearing on their socio-economic status. The study also noticed that breeding was rarely practiced thou pen-fattening was popular production systems among farmers. The marketing of the cattle was random and opportunistic, mainly to solve immediate family problems, with a small niche of farmers adopting business models such as pen fattening. Natural grazing was identified as the main source of feed, with minimal to no rangeland management system in use such as paddocking, this exposed the farmers to seasonal drought risks. Farmers highlighted challenges which they encountered, these ranged from lack of technical know-how due to limited access to advice from extension workers/experts, lack of infrastructure, lack of inputs, and diminishing herd sizes due to drought and diseases. The study concluded that cattle production remained a priority livelihood for the smallholder farmers with multiple roles including direct income and supporting other enterprises such as cropping. The smallholder participation in the BVC remains critical for the livestock development programmes. Recommendations were framed around capacity building efforts, innovations around extension methods, improving market access, herd rationalization and supporting modern farming practices such as breed improvement and feedlots.
Genetically tractable embryonic cell lines from sea urchins
Authors: Bodnar Andrea , Castellano Kate , Manner Carl , Kell Riss , McAtee Reanna , Capozzi Nicole , Wray Gregory
Published: January 2025

Sea urchins have been valuable research models for more than a century, significantly contributing to our knowledge of fundamental biological processes like cell cycle regulation and developmental gene regulatory networks. While an increasing number of functional genomic resources are being developed for sea urchins, in vitro cell culture tools and methods for scalable transgenesis have remained elusive. Here, we successfully established embryonic cell lines from sea urchins (Lytechinus variegatus and Strongylocentrotus purpuratus) which recapitulated aspects of the developmental program in vitro, generating 3D structures and a variety of morphologically and functionally distinct cell types representing all three germ layers. Single-cell transcriptional profiles revealed signatures of stem cells and distinct cell clusters expressing markers of neurons, myocytes, skeletogenic, endodermal, and pigment cells. The ability to genetically manipulate cultured cells was demonstrated using a lentiviral vector, providing a scalable approach for mechanistic studies that significantly expand the utility of this model organism.
Does the preliminary viewing of the embryo to be transferred on the monitor, followed by the ultrasound-guided transfer, lower the patient's stress? A descriptive and observational study
Authors: Baldini G. M , Lot D. , Malvasi A. , Laganà A. S. , Cerbone M. , Baldini D. , Trojano G.
Published: January 2025

The challenges associated with infertility and its treatments impose considerable psychological and physical burdens on patients, highlighting the critical need for patient-centred care to optimise therapeutic outcomes. This observational study assessed patient satisfaction with two specific aspects of in vitro fertilisation (IVF) treatment: ultrasound-guided embryo transfer and the opportunity to view embryos on a screen before transfer. Additionally, we explored the role of continuous care by the same physician in enhancing patients' sense of security and trust. The study was conducted at the IVF MOMO’ FertiLIFE center in Bisceglie, Italy, with 200 patients who completed a structured questionnaire assessing their experiences. Participants’ responses were evaluated using a 5-point Likert scale, specifically focusing on their emotional reactions to the transfer procedure, perceived levels of discomfort, sense of security, and preferences regarding continuity of care with the same physician. Statistical analyses included descriptive statistics, Spearman’s correlations, Friedman’s test, and factor analysis to explore relationships between variables and identify underlying factors. The findings revealed that ultrasound-guided transfer and embryo viewing significantly enhanced patients' emotional well-being, with many reporting increased feelings of calmness and security during the procedure. Continuity of care provided by the same physician was further associated with greater satisfaction and trust. These results underscore the psychological significance of patient-centred approaches, suggesting that integrating advanced technologies and promoting continuity in care could enhance the overall experience of IVF treatments, ultimately contributing to improved patient outcomes.
Social media addiction and its association with sleep quality and anxiety: A school-based cross-sectional study from Nepal.
Authors: Pradhan Laxmi , Adhikari Prakash , Shah Kriti , Bhusal Sandesh , Oli Kamana , Khanal Pratik , Singh Anil Kumar
Published: January 2025

Background
Excessive use of social media is linked with poor sleep quality and negative mental health outcomes. However, studies assessing the interplay of these three components among school children are exceedingly rare. This study aims to assess the levels of social media addiction, poor sleep quality, and anxiety among higher secondary school children, identify associated factors, and explore the correlations among these components.
Methods
This study was conducted among 418 higher secondary school students. Multivariable logistic regression at a significance level of 0.05 was employed to determine factors associated with social media addiction, poor sleep quality, and anxiety. Additionally, a correlation test was used to examine the associations between social media addiction, poor sleep quality, and anxiety.
Results
The prevalence rates of social media addiction, poor sleep quality, and anxiety were 33.5%, 64.4%, and 59.6%, respectively. Female students (aOR: 2.6; 95% CI: 1.6–4.1) and students from private schools (aOR: 3.7; 95% CI: 2.0-6.8) had greater odds of being addicted to social media. Students from the Brahmin/Chhetri ethnic group (aOR: 0.5; 95% CI: 0.3–0.9) had lower odds of experiencing poor sleep quality than the other groups did. Female students (aOR: 2.4; 95% CI: 1.6–3.6) were more likely to experience anxiety. Additionally, sleep quality and anxiety were weakly positively correlated with social media addiction.
Conclusion
Excessive social media use is associated with poor sleep quality and increased anxiety among Nepalese higher secondary students. Interventions such as face-to-face counseling, digital detox programs, and tailored approaches for high-risk groups are essential to address these issues and enhance their overall well-being.
Clinical trial number:
Not applicable
Methodology Development for Capturing Co2 and Precursor Gases of Greenhouse Effect From the Exhaust of Flex-fuel Internal Combustion Engines
Authors: Costa Theles
Published: January 2025

Derived largely from the combustion of fuels used in automotive vehicles, CO2 and precursor gases of greenhouse effect are important emission gases and deserve attention. This paper proposes a method to remove these gases by adsorption, through the capture and separation in exhaustion of vehicles with flex-fuel technology. The technique is feasible because it is based on the solid adsorption capacity and selectivity for CO2 and precursor gases. The characterization of the used adsorbents, natural ZN2040 and synthetic Oxan_X, show unique characteristics, especially the surface area, adsorption at low pressures, stability to wet gases, application at high temperature, high Si/Al ratio in the crystal structure and the presence of elements such as Fe, Ca, K and S. The adsorbents were arranged in a horizontal fixed bed column, installed in the front vehicle noise muffler of the exhaust system. The Oxan_X synthetic zeolite with improved performance, showed reductions in average of 2,20% of CO2 about 17% on the precursor gases, mainly CO, both for Gasoline 22% EAAF (Ethyl Alcohol Anhydrous Fuel) and ethanol burning. In addition, it allowed the reduction of other vehicle pollutants. In the long term, the use of vehicular fixed bed column contributes to a reduction of approximately 764000 tons of CO2 and 23300 t of CO when the vehicle is operating with Gasoline, and 1168000 tons of CO2 and 18000 t of CO when it is operating with Ethanol. Considering the vehicles of motorization 1.4 L to 2.0 L, and employing 2.0 kg of adsorbent.
LTCC-based broadband double-channel NMR coil with a split-spiral geometry
Authors: Liang Jianyi , Davoodi Hossein , Chau-Nguyen Khai , Badililta Vlad , Korvink Jan
Published: January 2025

In the field of nuclear magnetic resonance (NMR), planar spiral detector coils have been exploited for their ease of fabrication with a high tolerance for accommodating flat samples and for the ability to be integrated with microfluidic systems. Additionally, recent studies demonstrated the feasibility of designing such micro planar spirals for broadband operation1,2. Here we explore a novel embodiment of the planar spiral with a third contact added at an intermediary position of the spiral track, which acts as a double-channel NMR detector. The spiral geometry was optimized through simulation so that the inner loop and the full loop correspond to two frequency bands of interest. With the combined microfluidic and NMR devices fabricated for the first time in low-temperature cofired ceramic (LTCC) technology, we demonstrate untuned broadband operation by presenting 1D NMR spectra of 4 isotopes from 125MHz to 500MHz, as well as 2D 1H-13C HSQC measurements. The design is easy to use and shows high robustness, demonstrating potential for NMR studies of flow systems with multiple nuclei.
Bigatti shaver versus Bipolar electrocautry in management of endometrial polyps in infertile women
Authors: -Hassan Raya Muslim Al
Published: January 2025

Background:
Endometrial polyps may be characterized by heavy vaginal bleeding which needs surgical interventions like bipolar electrocautry surgery. They are commonly removed by excision using a resectoscope but this approach convey several complications like lack of complete removal, improper imaging , fluid intolerance and uterine or bowel injury .The new intrauterine Bigatti shaver (IBS) is a mechanical shaver that provides complete resection ,continuous fluid Input and deficit ,direct visualization and rare recurrence .Aim: To assess the intrauterine Bigatti shaver safety and value as hysteroscopic mechanical removal procedure for the management of endometrial polyps in comparison with resectoscope hysteroscopy.
Methods:.
The study was performed between October 2023 to October 2024 on sixty patients .All
demographics and operative information like set-up time, resection time and complications
were evaluated ,endometrial polyps were removed by two procedures, Bigatti shaver and resectoscope hysteroscopy .data collected and analyzed .
Results:
Sixty patients were divided into 2 groups for Bigatti shaver and resectoscope hysteroscopy
.There is significant difference in operating time between Bigatti shaver and resectoscope (2.46 ± 0.65, 7.44 ± 1.08 respectively ), in addition to significant difference in fluid input(1108.06±250.03, 1803.45 ± 431.14 respectively ) but fluid defecits have no significant
differences. In Bigatti shaver all patients have no bleeding as a complication when compared to resectoscope .
Conclusion:
.. The Bigatti shaver is a highly effective tool for the removal of endometrial polyps, offering a minimally invasive alternative to traditional methods. It combines mechanical tissue resection with continuous visualization, reduces the risk of uterine perforation and minimizes trauma to surrounding tissue, promoting faster recovery and enhanced patient outcomes
Suvmax of the Lesion Should Be Considered in the Treatment Plan for Stage I Non-small Cell Lung Cancer
Authors: Kocaman Gökhan , Ibrahımov Farrukh , Kahya Yusuf , Araz Mine , Elhan Atilla Halil , Enön Serkan
Published: January 2025

Objectives: High maximum standardized uptake value (SUVmax) is associated with poorly differentiated tumors and lymph node metastasis.It is still controversial which tumors can be treated with sublobar resection and there are publications stating that SUVmax of the tumor may be important in choosing sublobar resection. Our aim in this study is to examine the prognostic value of tumor SUVmax in stage 1 non-small cell lung cancer and to determine its place in sublobar resection preference.
Methods: The study included 314 patients who underwent wedge resection, segmentectomy or lobectomy for pathological stage I NSCLC with tumor size ≤3 cm between January 2008 and December 2020. SUVmax of the tumors are dichotomized according to ROC threshold value 5.2 and prognostic factors for recurrence-free and overall survival were analysed.
Results: In the multivariate survival analysis, SUVmax (p=0.012), lymphovascular and/or perineural invasion (p<0.001) and visceral pleural invasion (p=0.031) were found to be independent prognostic factors for recurrence-free survival (Table 2); age (p=0.027), sex (p=0.010) and SUVmax (p=0.036) for overall survival. While there was no difference between lobar or sublobar resection in terms of recurrence-free survival (p=0.647) in patients with SUVmax ≤5.2, lobectomy was found to be advantageous over sublobar resection for recurrence-free survival in patients with SUVmax >5.2 (76.6%±3.9% / 53.4%±12.1%, p=0.006, respectively)
Conclusions: High SUVmax (>5.2) is associated with poor recurrence-free survival and overall survival rates in pathological stage 1 NSCLC patients. In stage 1 patients, sublobar resection should be avoided if the primary tumor has a high SUVmax.
Assessment of Gonadal Hormones levels in Iron Deficient Females of Reproductive Age
Authors: Bani-Ahmad Mohammad A. , Hashim Jood M. , Khawaldeh Alia S. , Al-Odat Ibrahim A. , Al-Fawaeir Saad A. , Ahmad Abdelraheem A. Bani , Nazazleh Hiba A.
Published: January 2025

Background
Iron deficiency is a common malnutritional disorder with a wide variety of systemic clinical outcomes, including endocrine dysfunction. This study is a randomized descriptive study that, primarily, aimed to investigate that impacts of iron deficiency on the serum levels of gonadal hormones levels among females on reproductive age. To achieve so, a total of one hundred and twenty-three Female were included and were categorized by the menstrual phase based on obtained information form included subjects. Furthermore, based on their serum iron levels, subjects were subcategorized into iron sufficient (IS) and iron deficient (ID) females. Serum levels of iron, ferritin, Follicle-stimulating factor (FSH), Luteinizing hormone (LH), Progesterone, and estrogen were measured.
Results
No remarkable change in serum hormones levels during the follicular phase. During midcycle phase, ID subjects had significantly lower LH (17.49 ± 1.14 vs. 45.22 ± 6.31 IU/L, P < 0.001) and higher progesterone (11.2 ± 3.5 nmol/L vs. 1.95 ± 0.4 nmol/L, P < 0.05). Though it was statistically insignificant, the average serum estrogen among ID subjects was 128.4 ± 14.9 IU/L as compared to 202.4 ± 52.5 IU/L among IS females, P = 0.212. Serum LH and progesterone were significantly associated with serum iron levels (0.581, P < 0.005 and − 0.481, P < 0.05, respectively). Among ID females on luteal phase, significantly higher serum levels of estrogen (170.6 ± 9.5 pg/mL vs. 121.1 ± 13.1 pg/mL, P < 0.005) and progesterone (43.9 ± 3.3 nmol/L vs. 28.0 ± 4.1 nmol/L, P < 0.01). Furthermore, they were significantly associated with serum iron (-0.421, P < 0.05 and − 0.400, P < 0.05, respectively).
Conclusion
our data offers initial insights into the dysregulatory impacts of iron deficiency on the dynamic balance of gonadal hormones via the disruption of the hypothalamic-pituitary-gonadal-axis. Considering the positive feedback interaction, the main findings are the reduced levels of LH and estrogen below the optimal levels, during the luteal phase, in the context of iron deficiency. The reported impaired or delayed LH surge during the midcycle may reveal clinical impacts of iron deficiency on fertility and ability to conceive among females on reproductive age. Further investigation is required to validate our findings on a larger sample size and multiple time-points measurements throughout the menstrual phases of study subjects.
Aluminum Redox Catalysis: Cyclotrimerization of Alkynes
Authors: Zhang Xin , Liu Liu Leo
Published: January 2025

Aluminum catalysis has conventionally been limited to exploiting the Lewis acidic properties of the metal in its +III oxidation state. Herein, we show a low-valent aluminum species, specifically carbazolylaluminylene, which is capable of undergoing oxidative addition, twofold insertion, isomerization and reductive elimination processes via an Al(I)/Al(III) redox cycle—mimicking the quintessential steps characteristic of transition metal catalysis. This innovation enables effective, regioselective Reppe cyclotrimerization of alkynes to form a variety of benzene derivatives, achieving the highest turnover number of 2290. Through X-ray crystallography and quantum chemical analyses, we reveal that the adaptable nitrogen geometry of the carbazolyl ligand modulates the coordination environments at aluminum, thereby facilitating the catalytic cycle. Our work provides insights for further design and application of catalysis based on the main group redox cycle.
Development and Performance Evaluation of Microcontroller Operated Planter
Authors:   AICRP on FIM Scheme, PJTSAU, Telangana, Hyderabad, India, Kumar Ch. Sravan , Rajaiah P. , Vennela B. , Laxman B. , Pramod A.
Published: January 2025

Sowing is one of the important operations in crop production that involves factors like correct seed rate, appropriate depth of placement ad required seed space for maximum production. Ground wheel-driven conventional metering mechanism results in improper placement of seeds because of skidding and vibration of the ground wheel. To overcome this problem a microcontroller-based seed metering unit was developed and retrofitted to a planter. The microcontroller-operated planter was evaluated over ground wheel-driven planter for Maize seed. During the field trails it was observed that the average missing index, multiple index, and quality feed index of microcontroller operated planter was 6.6%, 10%, and 83.4% respectively. The average missing index, multiple index, multiple index and quality feed index of ground wheel-driven planter was 20.3%, 23.3%, and 56.4% respectively. It was also observed that sowing with a microcontroller-operated planter, there was a net saving of 20% of cost over ground wheel-driven planter.