bluuebunny/crossref_metadata_2025 huggingface dataset:
ROLE OF THE REGULATORY T CELLS IN PROGRESSION OF PROSTATE CANCER
Authors: Popov S. V. , Sturov N. V. , Vorobyev N. V. , Khaidukov S. V.
Published: October 2019

The existing data on regulatory T cells (Tregs) in prostate cancer suggest that these cells may penetrate the prostate gland malignant tissue, suppressing antitumor immune response, thus promoting aggressive clinical course and low survival of the cancer patients. Evaluation of T cell subpopulations from the tumor microenvironment has shown that the number of CD4+Tregs is associated with inferior clinical prognosis. In particular, each additional CD4+Treg cell has been shown to cause a statistically significant increase in prostate cancer mortality by 12%, regardless of other clinical factors. There are several possible explanations for the increased infiltration of prostate cancer tissue with regulatory T cells. Firstly, malignant cells or tumor-associated macrophages are capable of secreting chemokine CCL22, which has an affinity for the CCR4 receptor expressed on Treg cells. Secondly, cytokines secreted by prostate tumors, such as TGF-β, may regulate the FoxP3 expression, thus expanding the Treg population. TGF-β, in turn, is a multifunctional cytokine that promotes survival and proliferation of transformed cells, including prostate epithelium, as evidenced by increased amounts in the patients with metastatic disease.
ROLE OF CXCR3 CHEMOKINE RECEPTOR AND ITS LIGANDS IN CERTAIN DISEASES
Authors: Arsentieva N. A. , Semenov A. V. , Zhebrun D. A. , Vasilyeva E. V. , Totolian Areg A.
Published: October 2019

Chemokines are a special family of cytokines whose main function is to control cell migration; they are key players in the innate and adaptive immune responses. Directed chemotaxis of specific leukocyte subpopulations is necessary not only to maintain homeostasis, but also in development of some immunopathological conditions such as cancer, inflammation, infection, allergies and autoimmune disorders. Chemokines are pleiotropic molecules that are involved in physiological and pathophysiological processes. For example, the CXCR3 chemokine receptor is expressed on various cells: activated T and B lymphocytes, natural killers, eosinophils and neutrophils, dendritic cells, fibroblasts, endothelial and epithelial cells. Hence, CXCR3 and its ligands have a wide range of functional activity. CXCR3 ligands are the IFNγ-induced chemokines: CXCL9, CXCL10, CXCL11, and platelet-derived chemokines: CXCL4, CXCL4L1. All the CXCR3 ligands share common angiostatic properties due to lack of the Glu-Leu-Arg (ELR) motif. IFNγ-induced ligands of the CXCR3 are proinflammatory chemokines, they mainly recruit activated T cells and exert an effect on T cell polarization. Due to wide spectrum of biological activity, the ligands of CXCR3 receptor are involved in pathogenesis of various disorders, such as inflammation, infection, cancer, allergies and autoimmune disorders. In this review, we discuss the role of CXCR3 ligands in immunopathogenesis of various diseases, including the results of our studies in chronic hepatitis C, rheumatoid arthritis and pulmonary tuberculosis. Moreover, we have also discussed the potential laboratory diagnostic applicability of the chemokines in various diseases. This review illustrates a universal role of IFNγ-induced chemokines as mediators of immune responses in various diseases. The studies of CXCR3 ligands, their isoforms and receptors, interactions between themselves and with their receptors can provide a significant contribution to our understanding of the chemokine network. Understanding the system of IFNγ-dependent chemokines may have clinical implications, both for diagnostic tasks, and for therapeutic purposes.
СONCENTRATION OF ANTI-INFLAMATORY CYTOKINES IN CELL CULTURE SUPERNATANTS IN CHILDREN WITH JUVENILE IDIOPATHIC ARTHRITIS
Authors: Krivolapova I. M. , Pashnina I. A. , Chereshnev V. A.
Published: October 2019

Juvenile idiopathic arthritis is a chronic inflammatory disease of the joints in children, mainly of autoimmune or auto-inflammatory nature. It is a heterogeneous group, which includes different subtypes of the disease. Different mechanisms may play role in the pathogenesis of distinct subtypes of juvenile arthritis. However, a long-term imbalance of pro- and anti-inflammatory cytokines is important for all subtypes of disease. The aim of the present study was to determine spontaneous and stimulated anti-inflammatory cytokines production by peripheral blood cells from the children with juvenile idiopathic arthritis. Patients of 2 to 17 years old with different subtypes of juvenile idiopathic arthritis (n = 99) and healthy children without signs of autoimmune diseases (control, n = 31) were examined. Spontaneous and phytohemagglutinin-stimulated concentrations of IL-1ra, IL-4, IL-10, TGF-β in supernatants of whole-blood cultures were determined by ELISA. Differences in the spontaneous and mitogen-stimulated secretion of the cytokines in patients with different subtypes of juvenile arthritis have not been revealed. The spontaneous IL-1ra, IL-4 and IL-10 production by blood cells in the common group of patients with juvenile idiopathic arthritis was similar to the controls. The median value of spontaneous TGF-β concentration in the patients was below the detection level, whereas blood cells of healthy children had a higher potential of spontaneous TGF-β production. IL-4 and IL-10 production after incubation of peripheral blood cells with phytohemagglutinin in patients and in the control group did not differ from the controls, while IL-1ra and TGF-β synthesis was significantly lower than in healthy children.The spontaneous and/or stimulated production of IL-1ra, TGF-β by blood cells in children with juvenile idiopathic arthritis reflects the pathogenic significance of these cytokines in disease. Stimulation of cells can reveal a latent deficiency in the synthesis of cytokines, which is not evident when determining its concentration in serum or supernatants of spontaneous whole-blood cultures.
CHEMOKINE MARKERS ASSOCIATED WITH EARLY REJECTION OF KIDNEY ALLOGRAFT
Authors: Fedorenko T. V. , Kolesnikova N. V. , Pashkova I. A. , Porhanov V. A. , Gubareva E. A. , Kuevda E. V.
Published: October 2019

It is known at the present time that immunological biomarkers may become more sensitive, non-invasive methods of graft rejection diagnosis than those currently used. A growing amount of studies in animal models shows that chemokines, as active participants in the immune process, may be used to this purpose. Our earlier studies have shown an important prognostic significance of IL-6, IL-2, 17A and IL-1RA increase in pre-operative period as markers of acute kidney allograft rejection. When assessing changes in studied peripheral blood growth factors, we concluded that a sharp decrease in BDNF content is a diagnostically significant early sign of kidney allograft rejection. The aim of this study was to identify the prognostic role of serum chemokine levels at the preoperative stage, taking into account the production of anti-HLA antibodies during the post-transplant period as a risk factor of kidney allograft rejection. A comparative analysis of chemokine serum concentrations was performed in the patients with terminal-stage chronic kidney disease (CKD). In the patients from main clinical groups, the blood cytokine levels were measured 6 hours before transplantation, i.e., Eotaxin (CCL11), GRO-α (CXCL1), IL-8 (CXCL8), IP-10 (CXCL10), MCP-1 (CCL2), MIP-1α (CCL3), MIP-1β (CCL4), SDF-1α (CXCL12), RANTES (CCL5), MIG (CXCL9) by means of multiplex immunological assays, using appropriate test systems. The studies have shown significant changes in several chemokines in the CKD patients compared to age-matched controls. However, the following diagnostically significant biomarkers associated with early rejection of transplanted kidney should be considered: increased concentration of CCL2 and CCL4 chemokines, as well as an acute decrease in CCL11. Significantly decreased CXCL12 concentration in peripheral blood could be considered a marker of favorable posttransplant clinical course.  Occurence of HLA antibodies in recipients is also associated with elevated serum levels of CXCL8, CXCL10, CCL4, and CCL5.
The International Monetary Fund’s Role in Overcoming Economic Crisis in PIIGS
Authors:   Adam Mickiewicz University in Poznań, Jasiak Kinga
Published: October 2019

The financial crisis started in 2008 and touched the whole world but some countries experienced its consequences more than others. The European Union and in particular eurozone, slid into a stage of economic recession. Five of 28 EU countries faced the edge of financial fall, named PIIGS-Portugal, Italy, Ireland, Greece and Spain. Multidimensionality of the global crisis have caused that international economic organizations faced a great challenge, For them it was a test of efficiency and effectiveness. The leading role in this period belonged to the International Monetary Fund (IMF), which is standing on the guard of the whole international currency system. The aim of the article is to draw and analyze the most important IMF activities towards PIIGS, especially what instruments were proposed as a help and what changes had to be made by receiving states in order to receive the financial support. The ten-year perspective taken in the article allows for the more comprehensive assessment of the issue.
Relação conjugal: Desafios e possibilidades do “nós”
Authors: Porreca Wladimir
Published: October 2019

RESUMO A relação conjugal é constituída por três realidades distintas que interagem e se mantêm. O estudo buscou compreender os significados da permanência na relação conjugal de quatro casais brasileiros. A obtenção dos dados ocorreu por meio de entrevistas semiestruturadas e grupo focal. Para a interpretação dos dados, utilizou-se a análise de conteúdo, considerando três tópicos temáticos: a concepção de família e o amor conjugal; o casal e a relação conjugal; o permanecer casados. A família nuclear e o amor conjugal permanecem idealizados e desejados; a relação conjugal constitui uma terceira realidade, um “nós” conjugal, que com o passar dos anos de convivência, modifica as individualidades e colabora para que os casais permaneçam unidos.
Variables related to periodontal disease and peri-implant bone loss
Authors: GANDRA Ricardo Alexandre , FERNANDES Daniel Guião F , SILVA Iolanda L. Gomes Bianco , ZENÓBIO Elton Gonçalves
Published: October 2019

ABSTRACT The replacement of missing teeth by implant retained prostheses is a predictable form of rehabilitation in the population as a whole. Due to thesimilarity between periodontal disease and peri-implantitis, the hypothesis is inferred that patients with a history of periodontal disease would be more susceptible to peri-implantitis. This concept has been discussed and supported by new scientific evidence. The purpose of this review was to evaluate whether there is any relationship between periodontitis and greater peri-implant bone loss in periodontally compromised patients. The pertinent literature has concluded that rehabilitation by means of implants in patients with a history of periodontal disease was predictable and has shown success rates similar to those obtained in patients with no history of periodontitis.
Oral health knowledge of parents of children and adolescents with congenital heart disease
Authors: PINHEIRO Caroline Louise Sampaio , MEIRA Ana Cláudia Lima de Oliveira , SANTOS Aline Silva dos , SILVA Delson Araujo
Published: October 2019

ABSTRACT Objective: To assess the knowledge on oral hygiene, infective endocarditis, and antibiotic prophylaxis of parents of children and adolescents with heart diseases assisted at the Hospital Ana Nery (reference hospital), Salvador, Bahia, Brazil. Methods: Cross-sectional study with 43 guardians of children and adolescents aged 2 through 16 years, performed with the application of a questionnaire. Results: In the sample of parents studied, 64% had completed high school and 47% had a monthly family income of up to one minimum wage. The majority (81%) reported knowing that oral infections may lead to heart complications, 42% knew that oralbacteria may migrate to the heart, and 51% knew the term infective endocarditis. When questioned about antibiotic prophylaxis, 93% had no knowledge about it and 88% did not know the reasons for using antibiotics before dental treatment. Conclusion: Parental knowledge was limited and fragmented. Further attention is required when transmitting information to parents, focusing on prevention strategies in order to guarantee the integral health of these children and adolescents.
Alternative fixation system for implant-retained overdenture: case report
Authors: VALENTE Mariana Lima da Costa , CASTRO Denise Tornavoi de , BUENO Frank Lucarini , TEIXEIRA Ana Beatriz Vilela , SILVA Geyson Galo da , REIS Andréa Cândido dos
Published: October 2019

ABSTRACT The aim of this case report was to describe a prosthetic rehabilitation associated with an alternative model of polymer capsule for fixation system of implant-retained overdentures. Patient sought treatment at the clinic of School of Dentistry of Ribeirão Preto, due to lack of retention of their conventional total superior prostheses and inferior overdenture. The initial complaint was clinicallyconfirmed by altered intermaxillary relationships and severe reabsorption of the maxillary crest. In order to restore the function and improve its quality of life, it was proposed a prosthetic solution including implant fixed prosthesis to maxilla and a mandibular overdenture, with ball-type attachments associated with an alternative model of polymer capsule. This treatment was proposed inorder to reestablish the intermaxillary relationships and adequate occlusion, maintain retention and stability of the prosthesis. At the end of treatment and during a one-year follow-up of the case, the patient reported satisfaction and significant improvement in quality of life.
Types of traumatic dental injuries to the primary dentition and the surface against which they occurred
Authors: CASTILLO SÁNCHEZ Linda Patricia , ANDRADE Márcia Rejane Thomas Canabarro , AMERICANO Gabriela Caldeira Andrade , CRUZ Laís Rueda , DE MARSILLAC Mirian de Waele Souchois , CAMPOS Vera
Published: October 2019

ABSTRACT Objectives The aims of this retrospective study were to investigate the types of traumatic dental injury recorded in an oral health service within a ten-year period and to report the type of surface against which the traumatic dental injury occurred. Methods Dental records from children assisted in the Dental Trauma Clinic at the Rio de Janeiro State University’s School of Dentistry, between 2006 and 2016, were analyzed. Only those records who had registered some type of trauma in the primary anterior teeth (incisors and canines) and aged 0-96 months at the time of trauma were considered eligible for the study. Results Four hundred and eighty-three dental records were included, totalizing 786 traumatized teeth. The average age when traumatic dental injury occurred was 37.25 months (±18.62). Enamel fractures (32.8%) and intrusive luxations (45.6%) were the most prevalent types of trauma. The majority of traumas occurred against ceramic surfaces (34%). The greatest number of teeth with lateral luxation were the ones that hit against a ceramic surface (p=0.014; U Mann-Whitney test). According to this study, the most prevalent type of trauma in the dental tissue and pulp was enamel fracture and in the periodontal tissue was intrusive luxation. The majority of traumas occurred due to falls, at home and against ceramic surfaces. Conclusion The results showed that a high frequency of the lateral luxation was associated to a traumatic impact against ceramic surfaces.
Morphological and postharvest treatments in Alpinia cultivars
Authors: França Rozineide Pereira Alves de , Botini Auclar Felipe , Silva Celice Alexandre , Almeida Henrique Machado , Krause Willian
Published: October 2019

Abstract The characterization and morphological evaluation of plants are essential steps towards the germplasm classification and use in breeding. The objective of this study was to improve the morphological characterization of four Alpinia purpurata cultivars by means of qualitative evaluations to identify genotypes with promising traits for the ornamental plant market. Four cultivars of A. purpurata (‘Jungle King’, ‘Kimi’, ‘Red Ginger’ and ‘Pink Ginger’) were assessed in a partially shaded cultivation system. Quantitative morphological descriptors such as stem length and diameter, number of leaves on floral stem, leaf width and length, inflorescence width and length, fresh weight of floral stem and the number of produced and marketable stems were evaluated. The qualitative descriptors were evaluated on inflorescence, floral stem, petiole, leaf and bracts. Postharvest longevity was tested in a cold chamber (at 16 and 19°C) and at ambient temperature (26°C). The most outstanding quantitative traits of the cultivars ‘Jungle King’, ‘Kimi’ and ‘Pink Ginger’ were stem length and diameter, fresh weight, floral stem durability, inflorescence length and width and productivity. Cultivar ‘Red Ginger’ was less outstanding in the quantitative traits mentioned for the other cultivars. Variation among the cultivars was observed for inflorescence shape and color. The cultivars ‘Kimi’ and ‘Pink Ginger’ produced a stem yield of 6,654.32 and 7,580.24 ha-1 year-1, respectively, and cultivars ‘Red Ginger’ and ‘Jungle King’ 6,012.34 and 4,037.03 ha-1 year-1, respectively. The postharvest durability of the four cultivars evaluated under refrigeration exceeded 15 days and that of the control was less than 8 days. The qualitative and quantitative traits of the cultivars ‘Jungle King’, ‘Kimi’ and ‘Pink Ginger’ were promising for the tropical ornamental plant market.
Feasibility of the new method for orchid in vitro rooting using liquid and chemical sterilized culture medium under different sucrose concentration
Authors: Oliveira Beatriz Cristina de , Oliveira Maria Eduarda Barboza Souza de , Cardoso Jean Carlos
Published: October 2019

Abstract The in vitro propagation of orchids is the only commercial large scale technique to obtain healthy and high quality plantlets with clonal origin. The use of new technologies in plant tissue culture systems could lead to efficiency increases and costs reduction of micropropagation systems. The main actual micropropagation system is based on semi-solid culture media solidified using agar, followed by sterilization using autoclaving, and cultivation under photomixotrophic conditions using sucrose as main source of energy to plant in vitro culture. We proposed in this study the use of new micropropagation system using chemical sterilized liquid medium using polyurethane foam as support and LED source of light in rooting stage of Miltassia ‘Shelobie Tolkien’. Thus, the objective of this research was to test different concentrations of sucrose, comparing the conventional semi-solid agar-based culture medium (control) and the use of liquid medium with polyurethane foam support. The following sucrose concentrations were used: 0, 7.5, 15, 22.5 and 30 g L-1. The experiment was conducted in a 2 × 5 factorial, in a completely randomized design with ten replications each over a total period of 105 days of cultivation. The chemical sterilization using ClO2 showed 100% of decontamination in all treatments. The use of liquid media with polyurethane foam showed better results than plants cultivated in agar medium, and can be used for replace agar-based for orchid in vitro rooting.
Gender differences in school performance and attitudes toward school
Authors: Martínez Carmen Rodríguez , Gil Monsalud Gallardo
Published: October 2019

Abstract In this article we address gender differences in school performance and attitudes towards school using data from national (in Spain) and international evaluation reports and qualitative research to understand the perceptions of post-compulsory secondary students who continue their studies and do so successfully. Using a sample of twenty-six students (12 girls and 14 boys) who study Baccalaureate and Vocational Training, we investigate through in-depth interviews the shaping of feminine and masculine identities defined both in the reproduction of stereotyped cultural patterns as well as in the resistance and rupture. The findings reveal that girls have a clearer commitment to school work, being still very underrepresented in technical studies whose importance in the labour market is greater.
Plasmid: NK588 (pAct-nanoluc) v1
Authors: Booth David , King Nicole
Published: October 2019

The attached file is the full sequence for a plasmid that uses gene regulatory elements from S. rosetta to drive the expression of nanoluc luciferase upon transfection in S. rosetta. The plasmid is backbone is pUC19 and can be propagated in E. coli with Ampicillin selection.
Relationship between adherence to treatment and acceptance of illness in patients with type 2 diabetes
Authors: ÖZKAPTAN Bilge Bal , KAPUCU Sevgisun , DEMİRCİ İnci
Published: October 2019

Purpose: This study aimed at examining the relationship between patient acceptance of illness and adherence to treatment with type 2 diabetes mellitus.Materials and Methods: This cross-sectional, descriptive study was conducted in a state hospital in Sinop with 200 patients diagnosed with type 2 diabetes. The Patient Identification Form, Illness Acceptance Scale, and Adherence Scale to Type 2 Diabetes Mellitus Treatment were applied to collect the study data. Results: In our study, the mean score of the patients' acceptance scale was 24.12 ± 9.30 and 61.5% of the patients scored below this average. This indicates that patients' acceptance levels are low. When the scores of Type 2 Diabetes Mellitus Acceptance Scale were evaluated, their compliance with the treatment was found to be moderate (107.39 ± 13.55). There was a significant and negative relationship between the patients' illness acceptance scale scores and treatment adherence scale scores (-0.78).Conclusion: Majority of patients had low level of admission and moderate compliance to treatment.
Correlation between ventral neck muscle endurance and cervical progressive ısoinertial lifting capacity
Authors: TEKİN Gökşen , POLAT Sema , BALTACI Gül , GÖKER Pınar , KOZANOĞLU Erkan , YÜCEL Ahmet Hilmi , BOZKIR Memduha Gülhal
Published: October 2019

Purpose: The purposes of this study were to document the characteristics of ventral neck flexor muscle endurance (NMFE) and compare the endurance time to some anthropometric measurements due to genders in healthy young adult population. Materials and Methods: Measurements were taken from 185 medical students (104 males - 81 females) aged between 18-22yrs. Neck flexor (NF) endurance was measured with clinic endurance test, CROM (cervical range of motion) and head posture measurements were taken with CROM device and cervical physical performance was determined with progressive isoinertial lifting evaluation test (PILE). Neck pain and disability level were evaluated with the neck disability index (NDI). Results: Cervical range of motion and the NDI score were found significantly higher in females than in males. When the activity level increased, endurance time and PILE test components increased, however there was a weak correlation between endurance time and ROMs. Finally, it was observed that there was a relationship between NF muscle endurance and the NDI, range of motion (ROM), physical performance - activity level and lifestyle. Conclusion: It could provide important information to performance and endurance exercise studies program. Also, they may be helpful to assign patients to appropriate and most beneficial treatment programs, as well as to develop specific programs.
Gebelikte Sağlıklı Yaşam Davranışları Ölçeği’nin geliştirilmesi ve geçerlik güvenirliği
Authors: YILMAZ Esra , KARAHAN Nazan
Published: October 2019

Amaç: Bu çalışma Gebelikte Sağlıklı Yaşam Davranışları Ölçeği’nin geliştirilmesi, geçerlik ve güvenirliğinin incelenmesi amacıyla yapılmıştır. Gereç ve Yöntem: Araştırma 12 Mart-12 Eylül 2018 tarihleri arasında, Karabük Üniversitesi Eğitim Araştırma Hastanesi’nde uygulanmıştır. Araştırmanın çalışma grubunu, anılan hastanenin gebe izlem polikliniğine başvuran ve çalışmaya katılmayı kabul eden 718 gebe oluşturmuştur.Bulgular: Geliştirilmeye çalışılan “çok bileşenli ayrık yapıya” sahip ölçeğin; gebelik sorumluluğu, beslenme, hijyen, fiziksel aktivite, seyahat ve gebeliği kabullenme olmak üzere 6 (altı) alt ölçekten oluştuğu bulunmuştur. Ayrıca Cronbach alfa katsayıları; ölçek toplamı için 0.83, gebelik sorumluluğu alt boyutu için 0.71, hijyen alt boyutu için 0.64, beslenme alt boyutu için 0.72, fiziksel aktivite için 0.69, seyahat alt boyutu için 0.80 ve gebeliği kabullenme alt boyutu için 0.63 olup, test-tekrar test sonucunda Sınıf İçi Korelasyon katsayıları (SKK) 0.70-0.91 arasındadır. Sonuç: Bu sonuçlar Gebelerde Sağlıklı Yaşam Davranışları Ölçeği’nin geçerli ve güvenilir bir ölçme aracı olduğu ve çalışmalarda kullanılabileceğini göstermektedir.
Comparison of laparoscopic and open surgical techniques in adrenal masses in terms of outcome
Authors: DALCI Kubilay , TOPAL Uğur , ÜNAL Ayşe Gizem , ERAY İsmail Cem , YALAV Orçun , SAKMAN Gürhan
Published: October 2019

Purpose: The aim of this study was to compare the results of conventional and laparoscopic adrenalectomy in adrenal mass cases operated on during a 9-year period.Materials and Methods: A total of 81 patients who underwent adrenalectomy were included in the study. Patients were divided into two groups as; Group 1 - conventional surgery and Group 2 - laparoscopic surgery. Two groups were compared retrospectively on characteristics such as; age, sex, body mass index (BMI), American Society of Anesthesiologists' score (ASA), mass localization, mass size and hormonal activity of the mass, duration of operation, amount of bleeding in operation, duration of hospitalization, duration until food intake, perioperative mortality, early complications and readmission to hospital within 90 days. Results: There were 22 patients in Group 1 and 59 patients in Group 2. No statistically significant difference was found between the groups in terms of age, sex, BMI, ASA score, tumor localization, indications for operation, postoperative complication, perioperative mortality and re-admittance within 90 days. The hormonal activity of the mass was higher and the mass was smaller in size in Group 2. The duration of operation (min), the amount of bleeding in the operation (ml), the duration until oral intake (days) and the length of hospital stay (days) were found to be statistically significantly higher in Group 1.Conclusion: Laparoscopic adrenalectomy should be the preferred surgical method because of its short duration of operation, low blood loss, early onset of oral food intake and shorter hospital stay, as well as its safety.
Sedanter bireyler ve sporcularda substrat kesişim noktasındaki yağ oksidasyon hızlarının karşılaştırılması
Authors: GÜNAŞTI Özgür , ÖZDEMİR Çiğdem , ÖZGÜNEN Kerem T. , KILCI Abdullah , KORKMAZ ERYILMAZ Selcen , KURDAK S. Sadi
Published: October 2019

Amaç: Bu çalışmada sporcu ve sedanter bireylerin performans testleri sonucunda tespit edilen en yüksek yağ yakım aralıkları ve substrat kesişim noktalarındaki metabolik değişkenlerin değerlendirilmesi amaçlanmıştır.Gereç ve Yöntem: Çalışmaya 10 sedanter (22,1 ± 0,5 yıl) ve 11 sporcu (22,3 ± 0,6 yıl) olmak üzere toplam 21 erkek gönüllü katılmıştır. Katılımcıların egzersiz testleri yürüme bandında indirekt kalorimetre kullanılarak yapılmıştır (Cosmed Quark CPET). Uygulanan iki farklı egzersiz testi sonucunda katılımcıların performans düzeylerine ve yağ oksidasyon hızlarına ait veriler elde edilmiştir.Bulgular: Beden kitle indekslerine göre sporcular normal, sedanter bireyler ise fazla kilolu sınıfında yer almışlar ve sedanter bireylerin vücut yüzde yağ oranları sporculara kıyasla istatistiksel olarak anlamlı düzeyde yüksek bulunmuştur. Sporcuların pik oksijen alım seviyeleri anlamlı düzeyde yüksek olmasına karşın, en yüksek yağ oksidasyon hızları sedanter bireylere benzer seviyede tespit edilmiştir. Karbonhidratların baskın enerji kaynağı haline gelmeye başladığı kesişim noktasında, sporcu ve sedanter bireylerin oksijen alım miktarları arasında istatistiksel fark olmamasına karşın, bu değerin maksimal oksijen alım kapasitelerine oranı değerlendirildiğinde sporcu grupta istatistiksel olarak anlamlı düzeyde düşük bulunmuştur. Sonuç: Oksijen alım kapasitesi yüksek olan sporcu bireylerin hem en yüksek yağ yakım hızlarının hem de kesişim noktasındaki yağ yakım hızlarının sedanter gruba kıyasla istatistiksel farklılık göstermemesi, yağ oksidasyonunu belirleyen tek faktörün maksimal aerobik kapasite olmayabileceğini düşündürmektedir.
Kemik iliği kaynaklı mezenkimal kök hücrelerin deneysel Asherman modeli üzerine antiapoptotik ve proliferatif etkisi
Authors: ÖZTÜRK Şamil , KILIÇASLAN SÖNMEZ Pınar , ÖZDEMİR İlhan , TOPDAĞI Yunus Emre , TUĞLU Mehmet İbrahim
Published: October 2019

Amaç: Bu çalışmada Asherman sendromundaki (AS)endometriyal hasarlarda cerrahi yöntemlere ve medikal tedavilere alternatif olarak kök hücre tedavisinin etkileri araştırılmıştır.  Gereç ve Yöntem: Bu çalışmada sıçanlarda AS modeli kimyasal olarak oluşturuldu. Aynı türün erkek bireylerinin tibia ve femur kemiğinden izole edilen kemik iliği kaynaklı mezenkimal kök hücreler (KİMKH) AS oluşturulan dişi sıçanlara verilerek endometriyumda meydana gelen değişiklikler histopatolojik parametrelerle değerlendirildi. Asherman+ besiyeri, Asherman+ niş, Asherman+ KİMKH, Asherman+ KİMKH+ niş olmak üzere toplam dört grup oluşturuldu.Bulgular: Tedavi gruplarında epitel ve lamina propriyadaki rejenerasyonla birilkte endometriyal kalınlığın, bez sayısının ve vaskülarizasyonun arttığı, fibröz alanların ve apoptotik hücre ölümünün azaldığı  gözlenmiştir. Kontrol grubu olarak değerlendirilen sağ uterin hornlarda ise her hangi bir histopatolojik değişiklik görülmemiştir.Sonuç: KİMKH ve Niş uygulamalarının, infertiliteye neden olan mekanizmaların içerisinde yer alan adezyon oluşumunu azaltarakedavi ile kliniğe katkı sağlayabileceği gösterildi. Bu olumlu sonuçlar Asherman çalışmalarının kliniğe taşınabilmesi açısından ümit vericidir.
“Tot perdut e acabat”. Las procesiones por la gran sequía de Valencia a través de las crides del Municipio (1455-1457). La ciudad como escenario de piedad
Authors: Orts Ruiz Francisco
Published: October 2019

La ciudad y el Reino de Valencia vivieron entre los años 1455 y 1557 una de sus mayores sequías, tal y como se transmite de la documentación oficial y de los escritos de los cronistas de la época. Uno de los recursos más utilizados para combatir estas calamidades fue la convocatoria de procesiones en las que la población rogaba por el fin de estas. Proponemos en este artículo el estudio de estas manifestaciones de piedad desde el análisis de sus itinerarios y características comunes, en un intento de reconstruir el entramado de la piedad urbana en la ciudad medieval y su paisaje sonoro y visual.
Polish Dantism: between the Epic and Ethics
Authors: Marinelli Luigi
Published: October 2019

The Polish version of the article was published in “Roczniki Humanistyczne,” vol. 60 (2012), issue 1.

This essay proposes a synthesis of the major themes and issues of Polish Dantism, with a particular reference to the 20th century and beyond. The author retraces the traditional motifs which connect 20th-century authors to the Romantic tradition, and discusses some examples (Gombrowicz, Vincenz, Miłosz) in a broader comparative context (referring specifically to Eliot, Mandelstam, Brodsky). The author argues that the Modernist ethical idea of “necessary Dante” tends to be gradually replaced by a Postmodernist notion of “aesthetic Dante,” with a flowering of new translations—not only of the Divina Commedia. These works restore a balance between Polish literary Dantism and Dante studies. In this sense, the Polish situation displays a lot of similarity to the European and international context, abundant with trends and concerns which go far beyond those of a national language and literature.
The Study of Early Modern Literature (and Insects). A Comment to the Polemics
Authors: Hanusiewicz-Lavallee Mirosława
Published: October 2019

The Polish version of the article was published in “Roczniki Humanistyczne,” vol. 59 (2011), issue 1.

The article is the editor-in-chief’s comment to the discussion between Agnieszka Czechowicz and Paweł Bohuszewicz as presented in the current issue of the journal. The author defends philological methods in studying early modern literary texts and expresses her scepticism concerning any methods questioning and negating the fundamental epistemological difference between what is being studied and a researcher himself.
The Ordination of Religious in the Kuyavian Diocese in the First Half of the Sixteenth Century
Authors: Kaczmarek Krzysztof
Published: October 2019

The Polish version of the article was published in “Roczniki Humanistyczne,” vol. 62 (2014), issue 2.

The presented work makes reference to results of research on the ordination of religious clergy by bishops of the dioceses of Gniezno and Płock in the 15th and 16th centuries. The analysis of the contents of the books of pontifical acts of the Kuyavian bishops issued in the first half of the 16th century and the survey of selected books of the Włocławek Consistory permits the identification of more than 100 previously unknown members of the religious clergy originating chiefly from monasteries situated in the area of the Kuyavian Diocese, who received minor or major holy orders from their ordinaries and suffragans.
The Incarnate Logos in Gnostic Theology
Authors: Myszor Wincenty
Published: October 2019

The Polish version of the article was published in “Roczniki Humanistyczne,” vol. 58–59 (2010–2011), issue 3.

The popular version of Gnostic Christology in textbooks presents it as a Docetic Christology. The new texts by Christian Gnostics, uncovered in Nag Hammadi, prove that Gnostic Christology was first and foremost the Christology of the Church. It seems thus that Adolf Harnack’s term “the doctrine of two natures” describing the Gnostic approach is correct. The article quotes examples of Gnostic utterances from Tractatus Tripartitus of Nag Hammadi Codex I. Gnostic theology was close to Logos-centred Christology. The Gnostic statements also contain many other references to ecclesiastical theology. The author of Tractatus Tripartitus was clearly influenced by Church theology, but some ideas were later abandoned by the official doctrine of the Church.
Between Non-Fiction and the Literature of the Personal Document: Remarks on the Structure of Gustaw Herling-Grudziński’s Podróż to Burmy (A Journey To Burma)
Authors: Panas Paweł
Published: October 2019

The Polish version of the article was published in Roczniki Humanistyczne vol. 57, issue 1 (2009).

This text describes the literary structure (the immanent poetics) of Gustaw Herling-Grudziński’s 1952 diary Podróż do Burmy (A Journey to Burma) to properly situate this work in the domain of non-fiction and to indicate the most important characteristics of the writer’s diarist conception.
The Church’s Temporal Goods in the Work and the Final Document Drafted by the First Synod of the Diocese of Opole
Authors: Szymański Andrzej
Published: October 2019

In the article, a reflection is made on the legal regulations developed by the First Synod of the Diocese of Opole, concerning the management of temporal goods of the Diocese. The study presents the content of 17 statutes and 5 annexes (as well as considering earlier studies produced by one of the synodal working commissions, intended to be discussed by the parish synodal groups), and reflects on the completeness of the legal treatment of this vital yet complex area of ecclesiastical life.  The solutions adopted by the Synod should be considered incomplete, but the synodal legislator, that is the diocesan bishop, has the right to enact such particular norms as he deems appropriate and necessary.
The Scope of Protection of Legal Professional Privilege in Criminal Proceedings—Selected Issues
Authors: Krzyżanowski Piotr
Published: October 2019

The chief aim of this study is to explore the essence of legal professional privilege and analyse its scope in criminal proceedings. Legal professional privilege plays an essential role in the criminal process as it guarantees every individual the adequate exercise of his or her right of defence and to a fair trial. It should be stressed that the privilege is not uniform since there is dualism manifested by a distinction between defence lawyer's privilege and advocate's privilege, other than the former. The author discusses the Polish regulations and relevant case law. Also, amendments to the current regulations will be proposed.
The Concept of Relics and Canonical Recognition, Transfer and Preservation of the Mortal Remains of Servants of God According to the Instruction of the Congregation for the causes of Saints of 8 December 2017
Authors: Fiejdasz-Buczek Lidia
Published: October 2019

For the first time since the reform of canon law in 1983, the terminology regarding relics was included in an official document of the Holy See. The Instruction distinguishes between significant and non-significant relics. Referring to the decrees of the Sacred Congregation of Rites, it shows the reasons why this particular division was rightly introduced. The bishop of the diocese or eparchy where the mortal remains are preserved is competent to perform all the possible procedures on them, provided he has previously obtained the consent of the heirs and the consent of the Congregation for the Causes of Saints (different variants are possible). Apart from a tribunal, the bishop nominates expert pathologists to perform technical procedures and two witnesses. The article discusses the procedures of canonical recognition of the remains, extraction of fragments in case of the imminent beatification, and some final operations.
Legal Requirements for Pious Dispositions of Will According to the 1983 Code of Canon Law
Authors: Kaleta Paweł
Published: October 2019

The article examines legal regulations concerning pious dispositions of will contained in the 1983 Code of Canon Law. The research problem, that is, identification of the legal requirements for a lawful acceptance of pious will, indicates that anyone can effect voluntary dispositions of property for pious causes (c. 1299, §1), if he has the capacity to perform acts in law, subject to canon 668, §5. The legislator distinguishes three ways of disposing of property for pious causes: inter vivos (e.g. by a donation agreement), 2. mortis causa (e.g. by a will and testament, a testamentary legacy, or legatum), and 3. through trust for pious causes (c. 1302). In adopting pious dispositions of will, not only canon law, but also civil law should be respected, without prejudice to the supervisory authority of the ordinary bishop expressed in canon 1301, §§1 and 3; canon 1302, §§1 and 2, and canon 1304.
“… cum statuti tanta sit auctoritas, ut eius praeceptione omnia nobis conserventur.” Some Remarks on Wioletta Pawlikowska-Butterwick and Liudas Jovaiša’s Vilniaus ir Žemaičių Katedrų Kapitulų Statutai
Authors: Dyjakowska Marzena
Published: October 2019

The aim of this article is to present the edition of the statutes of the chapters of Vilnius and Samogitia authored by Wioletta Pawlikowska-Butterwick and Liudas Jovaiša. The presentation is preceded by a description of the history of both dioceses and remarks on the role of statutes as the source of the particular law of both chapters. Some space was devoted to the authors of the statutes and related issues. The editorial basis and the critical apparatus were discussed. Finally, attention was drawn to the illustrations accompanying the edition.
The Idea of Central Banking in the Final Years of the First Polish Republic
Authors: Łopuszyński Krzysztof
Published: October 2019

The need to establish a national bank in the Polish Republic was addressed in 1763 by Fr Stanisław Konarski in his O skutecznym rad sposobie. The need to secure the issue of Polish money increased as a result of the crisis caused by the flooding of the Polish market with Polish coins counterfeited in Prussia. The discussion was joined by proponents of mercantilism, who saw the possibility of keeping good Polish money in circulation by using dead capital in “deposit coffers.” However, only the Sejm could establish a central bank. The first drafts saw the light during the sessions of the Four-Year Sejm (1788–1792). Among them, the proposal of the famous Warsaw banker Jędrzej Kapostas deserves our attention, who in 1789 published a work entitled O banku narodowym w Polszcze and Planta ułożenia projektu Banku Narodowego in the next year. Paper money in Poland appeared in circulation during the Kościuszko Uprising. To this end, the Treasury Notes Administration was established, which issued so-called “assignments.” They survived until the fall of the uprising. The Third Partition of Poland put an end to the discussion of the establishment of a central bank.
The Effect of The Substitution of Ground Corn with Fermented Banana Weevil in The Concentrate Added to The Basal Feed on Blood Metabolite Level of Fattened Bali Cattle by Breeder Pattern
Authors: Rosnah Upik Syamsiar , Yunus Marthen , Maranatha Grace , Djoko Sulistijo Edi
Published: October 2019

This research is aimed at knowing the effect of the substitution of ground corn with fermented banana weevil in the concentrate as energy sources added to the basal feed of Fattened Bali cattle on the blood metabolite content (blood urea, blood sugar, and total blood proteins). This research was conducted in a field laboratory of Faculty of Animal Science in Oelatsala, Kabupaten Kupang. This research has twelve Fattened Bali cattle at range 2 – 2.5 years of age with average body weight 102,71 kg ±17,58 (KV=17,11%).The reseach method utilized is a trial method using randomize group design with four treatements and three replications. The treatements in this research are P0: basal feed of breeder pattern + concentrate (contained of 30% ground corn without fermented banana weevil), P1: basal feed of breeder pattern + concentrate (contained of 20% ground corn + 10% fermented banana weevil), P2:basal feed of breeder pattern + concentrate (contained of 10% ground corn + 20& fermented banana weevil), P3: basal feed of breeder pattern + concentrate (contained of 30% fermented banana weevil without ground corn). The data was analyzed using Analysis of Variance (ANOVA). The variable observed includes blood sugar, urea, total blood proteins, and blood cholesterol in Fattened Bali cattle. The result of statistical analysis shows that the substitute ground corn with fermented banana weevil in the concentrate added to the basal feed is not statistically significant (P>0.05) for the sugar blood, urea, total blood proteins, and blood cholesterol in Fattened Bali cattle. The conclusion of this research is that the substitute ground corn with fermented banana weevil in the concentrate added to the basal feed does not cause different profile of blood metabolite, especially, in terms of blood sugar, urea, total blood proteins, and cholesterol of Fattened Bali cattle.
Oxygen Sorption Treatment in the Treatment of Soft Tissue Wounds
Authors: Arkhipov Dmitry Valerievich , Andreev Alexander Alekseevich , Atyakshin Dmitry Andreevich , Ostroushko Anton Petrovich
Published: October 2019

Background. The number of patients with soft tissue wounds does not tend to decrease, which is largely due to the growth of patients with injuries, ulcerative defects, skin tumors, comorbid pathology, including diabetes mellitus, antibiotic-resistant strains and other causes. New methods of local treatment of wounds based on the application of the latest achievements of science are constantly being introduced into the work of surgical departments. High efficiency is demonstrated by the use of sorbents and oxygen, which enhance the reparative processes in wounds.The aim of the study was to study in experimental conditions the effectiveness of the method of surgical treatment of soft tissue wounds, based on the use of jet oxygen sorption treatment (SCS).Materials and methods. The study was performed on 150 white Wistar rats in 5 groups of animals. In the 1st control group treatment was not carried out. In the 2nd and 3rd control groups, the wound surface was treated with a jet of air and oxygen, respectively; in the 4th control group, sorbent was applied to the wound surface. In the 1st experimental group conducted scso wound surface. The study of the effectiveness of SCS was carried out using objective, planimetric, histological and histochemical research methods. Results. The use of sorbent (4th control group) and the method of jet oxygen sorption treatment (1st main group) led to the most pronounced positive changes-acceleration of relief of the studied symptoms by 1.1-1.3 times and 1.2 1.5 times, respectively, compared with the data obtained in the 1st control group. Treatment of wounds with oxygen jet (3rd control group) had practically no advantages in comparison with treatment with air jet (2nd control group).Conclusion. Indirectly, the highest activity of reparative processes during the observation period in the 4th control and 1st main groups was confirmed by the average optical density of RNA and SH-groups, and their desire to normalize to 10 days could indicate the completion of processes of stratification in the wound area. In total, the average area of wounds was minimal in the 1st experimental group, where this figure was by the 3rd and 10th days-74.0% and 99.5% compared to the baseline data.
Relationship between Ocular Surface Alterations and Concentrations of Aerial Particulate Matter
Authors: Gutiérrez María A , Giuliani Daniela , Porta Atilio A , Andrinolo Darío
Published: October 2019

Purpose: To evaluate ocular surface alterations in two populations at different exposure levels to particulate matter (PM) in their living and work environments.
Methods: A cross-sectional study was conducted, including 78 volunteers from Argentina who lived and worked under different pollution levels in an urban (U; n = 44) or industrial zone (I; n = 34). Mean exposure level to PM was evaluated. Responses to the Ocular Symptom Disease Index and McMonnies questionnaire were obtained from all subjects. Subsequently, an assessment through the Schirmer I test (ST), slit lamp microscopy, vital staining, and tear breakup time was conducted. Statistical analyses with Chi-square and Bartlett’s tests, as well as Student’s t-tests and principal component analysis (PCA), were performed.
Results: Particles of size < 2.5 μm (PM2.5) level was significantly higher in the I group than the U group (P = 0.04). Ocular surface parameters including bulbar redness, eyelid redness, and the degree of vital staining with fluorescein (SF) and lissamine green (SLG) exhibited difference between the groups. With regards to the tear film, statistically significant differences in the ST value and meibomian gland dysfunction between the groups were detected (P = 0.003 and P = 0.02, respectively). Conjunctival SF and SLG, and ST values were identified as factors which could distinguish groups exposed to different PM levels.
Conclusion: Subjects exposed to higher levels of PM in the outdoor air presented greater ocular surface alterations. Thus, ST, SF, and SLG values could be used as convenient indicators of adverse health effects due to exposure to air pollution.