bluuebunny/crossref_metadata_2025 huggingface dataset:
INVESTIGAR DESDE VINCULACIÓN CON LA SOCIEDAD
Authors: Riera Gloria , Ortiz Xiomar
Published: March 2022

Este estudio analiza la relación vinculación con la sociedad de la academia con la investigación. Con ese fin, revisa tres casos de intervención psicosocial desarrollados por la Facultad de Psicología de la Universidad de Cuenca (2018-2020) a la luz de una reflexión teórica sobre el significado de la vinculación y la investigación. Como resultado encuentra que la práctica de vinculación desde la intervención social se liga primordialmente con la docencia y, en cuanto a la relación vinculación/investigación, identifica ámbitos problemáticos como las diferencias entre la práctica de intervención y la de investigación, el valor epistemológico del conocimiento aplicado, y la carencia de investigadores en el medio. Como conclusión, se determina que para forjar una relación vinculación/investigación existen muchos retos, entre ellos, revisar las políticas administrativas de modo que propendan más adecuadamente la relación vinculación/investigación, revisar las políticas de impacto de las publicaciones, y mejorar los procesos de formación de investigadores.
La responsabilidad de las personas jurídicas. Un análisis a partir de los modelos legales de intervención
Authors: Oviedo Torres Fabián Andrés
Published: March 2022

En el actual debate sobre la responsabilidad de las personas jurídicas, resulta interesante proponer una mirada a la luz de las lógicas de los modelos legales de imputación tradicionalmente vinculados con su tratamiento (administrativo-penal). La posibilidad de legitimar un manejo diferenciado de los principios generales de ambos ordenamientos, especialmente del principio de culpabilidad, derivaría unas garantías y exigencias totalmente relevantes a la hora de decidir el tratamiento para los entes jurídicos. En ese sentido, este trabajo pretende explorar la relación existente entre las nociones de culpabilidad, presunción de inocencia y estándar de garantía, como aspectos determinantes para analizar el modelo del que se pretende hacer destinatarios a estos sujetos sociales. En últimas, lo que se pone de presente es una tensión entre un sistema basado principalmente en la eficacia y otro totalmente garantista.
Disseminated Herpes Zoster Presenting as Ogilvie Syndrome with Associated Pneumonia and Hepatitis in a Newly Diagnosed HIV Positive Male
Authors: Mabala Tshepang , Mfuta Nsekela Leticia
Published: March 2022

Varicella zoster virus (VZV) causes primary infection with varicella (chickenpox) a self-limiting diffuse vesicular rash and establishes latency in dorsal root ganglia. Reactivation of VZV results in a dermatomal vesicular rash known as herpes zoster. In the immunocompromised population, herpes zoster can develop into disseminated disease involving the sensory, peripheral and enteric nervous systems and be associated with extracutaneous manifestations. In this case report, we describe a HIV infected male presenting with Ogilvie syndrome in presence of disseminated herpes zoster with associated pneumonia and hepatitis.
Prawna natura obowiązku zapłaty podatku na podstawie wystawionej faktury – pomiędzy odpowiedzialnością a sankcją podatkową w podatku od towarów i usług
Authors: Nita Adam
Published: March 2022

Przedmiotem artykułu jest szczególnego rodzaju rozwiązanie prawne, ukształtowane w art. 108 ust. 1 ustawy o podatku od towarów i usług. W konsekwencji jego zastosowania wystawca faktury niedokumentującej rzeczywistej transakcji obowiązany jest uiścić podatek wykazany w tym dokumencie. Dzieje się tak, pomimo że wprowadzenie do obrotu tzw. pustej faktury nie jest przedmiotem opodatkowania w podatku od towarów i usług. Autor odnosi się do powszechnie głoszonej tezy, że konieczność zapłaty podatku na podstawie wskazanego wcześniej przepisu jest instrumentem ochrony państwa przed skutkami nienależnego odliczenia i zwrotu podatku od towarów i usług. Jednocześnie dowodzi on, że w pewnych okolicznościach efektem zastosowania dyspozycji art. 108 ust. 1 ustawy o podatku od towarów i usług może być ukształtowanie sankcji podatkowej.
Wirtualne społeczności lokalne Krakowa i ich potencjalny wpływ na jakość życia mieszkańców
Authors: Płaziak Monika
Published: March 2022

W opracowaniu omówiono znaczenie wirtualnych społeczności lokalnych w kontekście możliwości ich oddziaływania na jakość życia mieszkańców pomocniczych dzielnic samorządowych Krakowa. W tym celu zbadano wirtualne społeczności lokalne, funkcjonujące w portalu społecznościowym Facebook (w ramach witryn oraz grup nieekonomicznych i ekonomicznych). Poddano je obserwacji nieuczestniczącej i uczestniczącej, której wyniki posłużyły wskazaniu podejmowanych przez te grupy aktywności, mogących pośrednio i bezpośrednio wpływać na przemiany w sferze społecznej i przestrzennej dzielnic. Większość tego rodzaju społeczności ma ogólny zakres działań, służący integracji mieszkańców wokół różnorodnych zainteresowań i aktywności, np. informacyjny (informacje na temat najważniejszych przedsięwzięć i problemów w dzielnicy) i związany z lokalnym patriotyzmem. Zidentyfikowano jednak także działalności celowe, ukierunkowane na pewne grupy wewnątrz analizowanych społeczności lokalnych, np. rodziców, osoby uprawiające sport czy drobnych przedsiębiorców lokalnych. Szczególną rolę w integracji społeczności dzielnicowych, wpisującą się w aktualny obecnie trend ekonomii współdzielenia, odgrywają grupy ekonomiczne typu „zamienię, oddam”.
Contemporary trends in urban allotment gardening: The example of family plots in Warsaw
Authors: Mokras-Grabowska Justyna
Published: March 2022

The study aims to gain an insight into current trends in the use of four selected allotment gardens (rodzinne ogrody działkowe – RODs) in Warsaw (Poland): ROD ‘Pratulińska’, ROD ‘Obrońców Pokoju’, ROD ‘Kolejarz’ and ROD ‘Zelmot’. The main method used in the research was a survey of plot holders (structured interviews, n = 210). The findings suggest that holders are mainly older, retired people, but the number of younger plot holders has been increasing in recent years. Most live on huge estates in close proximity to the allotment gardens. The main motivations for having a plot are relaxation, gardening as a hobby and connection with the natural environment. Food production itself was not mentioned as a prior motivation. The meaning of having a plot corresponds with motivations. Some plot holders emphasize having their own, private place (a kind of second home, refuge, respite from city life). Most of the respondents have positive opinions regarding opening allotment gardens to local communities, although they are not very eager to participate in integrational events and activities organized by the Polish Association of Allotment Gardens (PZD) or others. The findings are in line with global trends presented in research exploring allotment garden recreational space in Poland and abroad.
Nutritional Efficacy of Maize based Functional Flour Developed for Minimizing the Risk of Lifestyle Diseases in Relation to Normal Wheat Flour
Authors: Yadav Anjali , Singh Usha
Published: March 2022

Background: Lifestyle diseases are ailments caused due to unhealthy living pattern. Maize being an affordable and inexpensive cereal crop for unprivileged people and has potential benefits also which can be utilized with other grains to develop functional flour. Methods: The present investigation was conducted during 2020-21 in the Laboratory of Department of Food and Nutrition, Dr. RPCAU. The raw ingredients viz. maize (variety ‘Lakshmi’), flaxseed, chickpea, barley, ragi and wheat were procured from local market Pusa or farmers. After processing with various methods, different proportions of flour were developed. Bulk density, water absorption capacity and proximate composition were determined. Result: The result showed that bulk density ranged from 0.57 to 0.67 g/ml, whereas water absorption capacity varied from 1.08 to 2.16 g/ml. Proximate composition such as moisture content ranged from 6.53 to 11.55 g/100 g, ash 1.26 to 1.9 g/100 g, protein 5.83 to 11.08 g/100 g, fat 1.60 to 5.33 g/100 g, fibre 11.09 to 18.27 g/100 g, carbohydrate 56.45 to 65.09 g/100 g whereas level of minerals like iron varied from 3.68 to 5.71 mg/100 g, zinc 2.83 to 3.76 mg/100 g and calcium 25.73 to 132.28 mg/100 g.
Molecular Characterization of Free Living N2 Fixing Bacteria Isolated from Agricultural Soils of North Gujarat, India
Authors: Patel P.H. , Panchal K.S. , Patel H.P.
Published: March 2022

Background: Molecular identification of a wide range of organisms capable of carrying out biological nitrogen fixation (BNF) are diverse in nature and significantly improves plant growth. Biological N2 fixation reflects the activity of a phylogenetically diverse list of microorganisms. Molecular characterization provides efficient means to identify organisms with the potential of N2 fixation. Applying these techniques in an array of environments has considerably broadened our understanding of the suite of organisms that can carry out BNF. Methods: Thirty-four strains of free living N2 fixing bacterial strains were isolated from diverse plants cultivated in North Gujarat, including wheat, cotton, castor and pearl millet, using a nitrogen-free selective medium. Acetylene reduction assay was used to check the ability of all bacteria to fix nitrogen. Hybridization with nifH probe derived from Azotobacter vinelandii with isolated free-living nitrogen-fixing bacteria showed a positive result. The selected strains were characterized by molecular analysis like; ARDRA and 16S rDNA sequencing. Result: Based on molecular characterization 17 strains to known groups of nitrogen-fixing bacteria, including organisms from the genus Azotobacter, Pseudomonas, Enterobacter, Arthrobacter, Bacillus, Variovorax, Nocardiodies, Rhodococcus, Mycobacterium, Planococcus, Microbacterium have been identified. One of the strains was identified as unknown bacteria. The potential strains were identified by 16srDNA analysis and also corroborated by morphological and biochemical characterization.
​Effect of Various Plant Powders on Pulse Beetle, Callosobruchus maculatus (F.) (Coleoptera: Bruchidae) and Seed Weight Loss in Stored Black Gram
Authors: Govindan K. , Geethanjali S. , Douressamy S. , Brundha G.
Published: March 2022

Background: Pulse beetle, Callosobruchus maculatus is the most serious pests in stored legumes in majority of tropical countries. Attention has been given to the possible use of plant products or plant dry powders as promising alternatives to synthetic insecticides in controlling insect pests of stored products. Present study seven plant species evaluated for their bio activity to pulse beetle. Methods: Laboratory studies were conducted at Department of Crop Protection, Agricultural College and Research Institute, Valavachanur, Thiruvannamalai District to study the effect of various plant powders tested against, Callosobruchus maculatus (F.) infesting stored black gram. The experiments were conducted two sets, first experiment (insecticidal action) and second on ovipoistion, egg hatchability, adult emergence and seed weight loss. Result: The Piper nigrum 2 per cent seed powder was found to be significantly the best compared to other treatments and caused 100 per cent mortality at one day after treatment. At seven days after treatment, Azadirachta indica (87.77%), Coccinia indica (80.50%), Abutilon indicum (73.50%), Acalypa indica (73.33%) and whereas untreated control recorded only 36.66 per cent mortality was recorded. Piper nigrum was significantly superior than all other treatments in complete inhibiting the oviposition, adult emergence and seed weight loss showed in P. nigrum 2 per cent seed powder treated black gram seeds as compared to untreated control higher numbers eggs laid (107 eggs), adult beetle emergence (90 adults) and seeds weight loss (34.26%) at 30 DAT, (39.22%) at 45 DAT and (45.28%) at 60 DAT. Different concentration of P. nigrum seed powder experiment results concluded that all the four doses (0.50, 1.00, 1.50 and 2.00%) highly effective against C. macultus viz., mortality, oviposition adult emergence and seed weight losses.
Contenido de metales pesados en varios ríos de Costa Rica
Authors: Quirós-Bustos Noemi , Robles-Chaves Diana , Caballero-Chavarría Andrey , Calvo-Brenes Guillermo
Published: March 2022

Costa Rica posee una riqueza hídrica importante; sin embargo, varios ríos presentan niveles de contaminación altos. Un tipo importante de contaminantes son los metales pesados (MP) que pueden tener un efecto adverso en la salud en personas, animales y plantas. Su no biodegradabilidad y su bioacumulación ocasionan efectos tóxicos duraderos. Existe poca información sobre MP en los ríos de Costa Rica; por eso el propósito de esta investigación fue evaluar la calidad de varios ríos ubicados en distintas regiones del país. Se seleccionaron 26 sitios de muestreo y se evaluó el contenido de 7 MP entre el 2017 al 2018. Los MP evaluados fueron: plomo, cromo total, cadmio, mercurio, cobre, arsénico y níquel. Se encontró presencia de cada uno de los metales. En general, no se observaron diferencias de MP entre la época seca y la lluviosa. La presencia de arsénico solo se encontró en los ríos Tempisque y Toro; en el primer caso los valores usualmente sobrepasaron la normativa nacional. Algunos MP evaluados mostraron concentraciones cercanas al límite máximo recomendado. El caso del mercurio sobresalió entre los datos pues estuvo presente en el 61,5% de los sitios muestreados y en la mayoría de ellos sobrepasaron la normativa nacional.
Efecto de niveles de aplicación de guano de islas en incremento de frutos de cacao
Authors: Parco-Quispe Maximo , Camacho-Villanueva Alina Alexandra , Parco-Quinchori Jhimy Andy , Dionisio-Saldaña Fiorela Edith
Published: March 2022

El experimento se realizó en dos campañas agrícolas, por problemas de baja productividad del cultivo de Cacao orgánico en la Selva Central, con el objetivo de determinar la dosis óptima de aplicación de guano de islas por planta, elevar la productividad del cacao y el ingreso económico de los productores, las cantidades que se aplicaron por tratamiento fueron: T1 300 g, T2 400 g, T3 600 g, T4 800 g, T5 1000 g, y T6 sin abonamiento. Las aplicaciones se realizaron en dos momentos: la primera dosis (50 %) antes del inicio de la floración en el mes de octubre de 2016 y la segunda durante el crecimiento de frutos en el mes de marzo de 2017. En la segunda campaña 2017 y 2018 se siguió el mismo procedimiento. Las variables evaluadas fueron: número de frutos por planta, peso de mazorcas maduras, número de almendras por mazorca, peso de almendras secas por mazorca y rendimiento de almendra seca/ha. La aplicación de guano de islas se realizó haciendo pequeños hoyos en media luna en la parte alta a 50 cm de distancia del tallo de la planta, como resultado se encontró un incremento en número de frutos por planta, peso de mazorcas maduras, numero de almendras por mazorca y peso de almendra seca. En conclusión, las dosis que influyeron en mayor productividad de cacao, fueron T4 800 g y T5 1000 g por planta, también se observó que en la primera campaña el incremento fue mayor que la segunda campaña.
Ruh Sağlığı Okuryazarlığı: Farkındalık ile Toplum Ruh Sağlığını Güçlendirme
Authors: ÖZER Duygu , ŞAHİN ALTUN Özlem
Published: March 2022

Günümüzde artan ruhsal sorunlar nedeniyle, toplumun ruh sağlığını korumak ve güçlendirmek daha da önemli bir konu haline gelmiştir. Ruhsal bozukluklar hakkında toplumların bilgi eksikliklerinin ve damgalayıcı tutumlarının olması, ruhsal bozuklukların erken dönemde etkili bir şekilde tedavi edilememesine sebep olmaktadır. Bu bağlamda, koruyucu ruh sağlığı hizmetleri kapsamında toplumun ruh sağlığı okuryazarlığını arttırmak önemli bir adım olacaktır. Ülkemiz için ruh sağlığı okuryazarlığı, çok yeni bir kavram olup, tam olarak bilinmemektedir ve bu konuda yapılmış çalışmalarında sınırlı olduğu görülmektedir. Bu nedenle bu derlemede, ruh sağlığı okuryazarlığı kavramı, önemi, geliştirmeye yönelik müdahaleler ve bu konuda psikiyatri hemşirelerinin neler yapabileceği tartışılacaktır. Bu derleme, literatüre önemli ve güncel veriler kazandıracak ve ruh sağlığı okuryazarlığı müdahale çalışmalarının yapılması gerektiği konusunda ruh sağlığı profesyonellerine farkındalık kazandıracaktır.
Mejoramiento a la compresión, flexión y tracción del concreto con agregado grueso reciclado, fino natural y virutas de acero para el uso de viviendas en Lima Metropolitana
Authors:   , Alor Suarez Johnny Santiago , Alfaro Paredes Juan Carlos
Published: March 2022

El siguiente Trabajo de Investigación se realizó con la finalidad de analizar el comportamiento de un Concreto con Agregado Grueso Reciclado, Agregado Fino Natural y adicionando Virutas de Acero con un porcentaje de 8%, 10% y 12% con respecto al Agregado Fino y determinar el aumento de las Resistencias a la Compresión, Flexión y Tracción en cada uno de los casos. El proceso comienza por conseguir los materiales; concreto reciclado producto de residuos de construcción y demolición y Virutas de Acero producto de residuos de procesos mecánicos. Se realizaron ensayos en laboratorio de los agregados y de las virutas para la identificación de sus propiedades y ser utilizados como datos para elaborar el diseño de mezcla correspondiente a cada caso. Teniendo ya los diseños para los 4 casos, se elaboraron en 48 probetas, 12 por cada diseño, en el ensayo de resistencia a Compresión, mientras en el ensayo de resistencia a Flexión, se elaboraron 12 vigas y para el ensayo a resistencia a Tracción se 12 probetas, haciendo un total de 72 especímenes, los cuales serán analizados a los 7, 14, 21 y 28 días de curado con la finalidad de determinar el porcentaje óptimo de adición de Virutas de Acero y el Costo de Producción de este, demostrando de esta manera que se puede obtener un concreto eficiente y a un precio económico.
ANALISIS TINGKAT KEBANGKRUTAN PERUSAHAAN ASURANSI SYARIAH DI INDONESIA DENGAN ANALISIS DISKRIMINAN
Authors: Rahmawati Ely , Zulaikha Siti
Published: March 2022

This study aims to determine the effect of financial performance represented by liquidity ratios, investment and liability ratio, claim expenses, ROA, VOC, and company size on bankruptcy risk. This research was conducted on Islamic insurance companies registered with the Financial Services Authority in the period 2012 to 2018. The statistical model used to test the hypothesis in this study is discriminant analysis at the significance level of 5% (α = 0.05). The results showed that the ratio of investment and liability balances, the ratio of claims expenses, the ratio of return on assets (ROA), volume of capital (VOC) and company size significantly influence the risk of bankruptcy of Islamic insurance companies. However, the dominant financial performance ratios that form the discriminant function in Islamic insurance companies are return on assets, the ratio of claim expenses, and company size.Keywords: Financial Performance, Bankruptcy Risk, Altman Z-Score, Sharia Insurance Company
Influence of elicitors application to Monastrell and Tempranillo vineyards on grape nitrogen composition over two vintages
Authors: Garde-Cerdán Teresa , Pérez-Álvarez Eva P. , Fernández-Fernández José I. , Gil-Muñoz Rocío
Published: March 2022

Currently, elicitors have been used to induce the defence mechanisms of vines, i.e., against both abiotic and biotic stresses. Besides, increases in phenolic synthesis in grapevines have been reported after elicitors application. However, its effects on the grape nitrogen composition are not entirely known. Thus, this work aimed to study the effect of methyl jasmonate (MeJ) and a yeast extract (YE) applied in Monastrell and Tempranillo grapevines on grape amino acids during two consecutive seasons. Amino acids in grapes were analysed by HPLC. In the first season, the total amino acid content in grapes decreased in Monastrell after MeJ and YE applications from 2236 to 1580 and 1620 mg L-1, respectively, while in Tempranillo, the total amino acid concentration decreased after YE applications from 2355 to 1811 mg L-1. However, during the second season, elicitors did not affect total amino acid concentration. The most important components of variability in amino acid concentration were the grape variety and the season. These results provide new knowledge of the effect of two elicitors in two important red varieties on grape amino acids content, relevant for wine quality.
Une dynamique européenne de la wilderness
Authors: Miko Ladislav , Aykroyd Toby , Vallauri Daniel , Barthod Christian
Published: March 2022

En 2009, l’adoption par le Parlement européen, à la quasi-unanimité, d’une résolution demandant une politique communautaire de la « wilderness », et les débats afférents menés sous les présidences tchèque et belge ont révélé au grand jour une nouvelle sensibilité découlant de l’élargissement à l’Est de l’Union européenne. Mais ceci a été rendu possible par un grand nombre d’initiatives convergentes prises depuis la fin des années 1990 par des associations à visée européenne, travaillant de manière plus ou moins articulée avec la Commission européenne. C’est un long processus, de plus en plus actif et structuré, qui a conduit à ce que la stratégie européenne pour la biodiversité, adoptée en 2020, promeut la protection stricte de toutes les forêts relictuelles qualifiées de « old growth and primary forests » en anglais. La France n’a pas été active au niveau européen sur ce sujet, mais il est néanmoins possible d’y voir lentement monter l’intérêt pour ce sujet depuis les années 1990, mais avec une sensibilité propre.
Libre évolution des forêts et maîtrise du risque sanitaire associé aux scolytes des conifères
Authors: Jactel Hervé , Marini Lorenzo
Published: March 2022

Les forêts tempérées subissent un fort accroissement des attaques d’insectes ravageurs en réponse aux changements climatiques comme en attestent l’augmentation récente des pullulations de scolytes des conifères. Avec l’interdiction des insecticides et l’impasse de la sélection génétique, adapter la gestion des forêts pour prévenir ou contrôler ces infestations demeure la meilleure option. En termes de prévention, l’augmentation de la diversité des essences forestières, associant conifères et feuillus, permet de réduire la densité d’arbres hôtes, de renforcer leur vigueur, de perturber les processus de colonisation et de maintenir les ennemis naturels, améliorant globalement la résistance des peuplements aux attaques de scolytes. En termes de lutte, les coupes sanitaires visant à évacuer les bois scolytés et à limiter leur substrat de développement ne sont que rarement efficaces, à moins d’être pratiquées rapidement en visant la quasi-totalité du volume de chablis. Les forêts en libre évolution, pourvu qu’elles soient composées d’un mélange équilibré d’essences contrastées, n’apparaissent donc pas intrinsèquement plus vulnérables aux attaques de scolytes.
Implikasi Penambangan Pasir terhadap Perekonomian Petani
Authors: Anggun Brilianti Popy , Sutopo Umarwan
Published: March 2022

One of the uses of natural resources is sand mining, as happened in the village of Bolosingo, Pacitan. However, these activities have a negative impact on the environment that affect the economy of the surrounding farmers. Damage to agricultural land make it unproductive and result in sub-optimal yields. The study aims to explain the maqashid sharia review of sand mining which has an impact on the damage to agricultural land in the village of Bolosingo, Pacitan and a review of maqashid sharia on the socio-economic impact of the surrounding community in the village of Bolosingo, Pacitan. The research method used is a qualitative method. With data collection techniques through observation, interviews and documentation. From this research, it can be concluded that the implications of sand mining for farmers in the village of Bolosingo, Pacitan which have an impact on the damage to agricultural land are not in accordance with the maqashid sharia, which has not realized the benefits to be achieved both in the world and in the hereafter. From the impact of the need to protect the environment from damage and greed caused by human hands. While the socio-economic impact of sand mining on the farmer’s economy is not appropriate according to the maqashid sharia hifdzu nafs and hifdzu mal, because the negative impact caused by sand mining has a greater risk than the benefits.

Salah satu pemanfaatan sumber daya alam adalah penambangan pasir seperti yang terjadi di Desa Bolosingo Pacitan. Namun demikian, kegiatan tersebut menimbulkan dampak negatif pada lingkungan yang berpengaruh terhadap perkonomian petani sekitar. Rusaknya lahan pertanian menjadikan tidak produktif dan berakibat hasil panen tidak maksimal. Kajian ini bertujuan untuk menjelaskan tinjauan maqāṣhid syarī’ah terhadap penambangan pasir yang berdampak kepada kerusakan lahan pertanian di Desa Bolosingo Pacitan dan tinjauan maqāṣhid syarī’ah terhadap dampak sosial ekonomi masyarakat sekitar di Desa Bolosingo Pacitan. Metode penelitian yang digunakan adalah metode kualitatif. Dengan teknik pengumpulan data melalui observasi, wawancara dan dokumentasi. Penelitian ini dapat disimpulkan bahwa implikasi penambangan pasir terhadap petani di Desa Bolosingo Pacitan yang berdampak pada kerusakan lahan pertanian belum sesuai dengan Maqāṣhid Syarī’ah yaitu belum mewujudkan kemaslahatan yang hendak dicapai baik didunia maupun diakhirat. Dari dampak yang ditimbulkan perlunya untuk menjaga lingkungan dari kerusakan dan keserakahan ulah tangan manusia. Sedangkan dampak sosial ekonomi dari adanya penambangan pasir terhadap perekonomian petani belum sesuai menurut Maqāṣhid Syarī’ah hifdzu nafs dan hifdzu mal, karena dampak negatif yang ditimbulkan penambangan pasir memiliki resiko yang lebih besar daripada manfaatnya.
SARS-CoV-2 Result Interpretation based on Image Analysis of Lateral Flow Devices
Authors: Vashistha Neeraj
Published: March 2022

The widely used gene quantisation technique, Lateral Flow Device (LFD), is now commonly used to detect the presence of SARS-CoV-2. It is enabling the control and prevention of the spread of the virus. Depending on the viral load, LFD have different sensitivity and self-test for normal user present additional challenge to interpret the result. With the evolution of machine learning algorithms, image processing and analysis has seen unprecedented growth. In this interdisciplinary study, we employ novel image analysis methods of computer vision and machine learning field to study visual features of the control region of LFD. Here, we automatically derive results for any image containing LFD into positive, negative or inconclusive. This will reduce the burden of human involvement of health workers and perception bias.
Oxidative stress and inflammatory response of AgNPs and chitosan-coated AgNPs (25nm) via different doses in mice
Authors: Gooda Samar M , El-Azeem Eman M Abd , El-Rigal Nagy S , Ali Sanaa A , Khalil Wagdy KB , Medhat Amina M
Published: March 2022

Objective
The cytotoxicity of AgNPs in mice comparatively with chitosan-coated AgNPs. Silver and chitosan–coated AgNPs of average size 25 ± 5 nm, which were prepared and characterized at Nanotech Egypt for Photo-Electronics
Methods
Male mice were administered with different doses of 25, 50, and 100 mg/kg of both nanoparticles, oxidative stress markers; liver functions, pro-inflammatory cytokines and some tumor markers were measured
Results
AgNPs significantly increased malondialdehyde and nitric oxide levels. Moreover, it was found that AgNPs significantly increased the levels TNF-α and IL-6 as well as the levels of α-L-fucosidase and arginase and DNA damage measured by comet assay. On the contrary significantly decreased superoxide dismutase and reduced glutathione levels. They also led to deteriorations in serum aminotransferases, alkaline phosphatase and γ-glutamyltransferase levels, chitosan–coated AgNPs reduced the inflammatory caused in hepatic cells.
Conclusion
Chitosan–coated AgNPs was decreased AgNPs toxicity, by improving the biochemical parameters enrolled in this study, chitosan–coated AgNPs had less cytotoxic effects on liver function, and inflammatory biomarkers.
Determining effective threshold range of image pixel values for municipal waste contaminated clay
Authors: Zhang Rui , Cao Liwen , Feng Xuehan , Wang Shenglin , Cai Nian , Guo Yuliang
Published: March 2022

Nowadays, more attention has been paid to the study of the properties and structure of contaminated clay, while there are few studies on the microstructure of contaminated clay, especially municipal waste contaminated clay. The purpose of this paper is to determine the threshold range by observing and processing the microscopic images of municipal waste contaminated clay with different seepage depths and concentrations. In this study, contaminated clay samples were taken at different depths in a column test and at different concentrations with CaCO3 and CH3COOH, imaged through scanning electron microscopy (SEM), and then subjected to binarization. Five steps for determining the pixel thresholds were discussed including: imaging contaminated clay through SEM, preprocessing and binarizing the SEM images with IPP, carrying out morphological processing by using PCAS and determining the pixel threshold value of the SEM images. The apparent porosity ratio of the contaminated clay and the fractal dimension of the clay particles were applied as the parameters for evaluation, the effective threshold range of the image pixel values of the municipal waste contaminated clay was determined to be 110–140. This method is validated by examining the relationship between the pixel threshold value and apparent porosity ratio, the variation in the porosity ratio and apparent porosity ratio with seepage depth, and the different compaction factors with seepage depth.
Determinants of burden and quality of life of informal caregivers of individuals with dementia
Authors: Rosa Mário Miguel , Lindeza Patrícia , Ferreira Lara , Guerreiro Manuela
Published: March 2022

Introduction: Little is known about the impact of dementia in the quality of life (QoL) and overall burden of informal caregivers. The aim of the study is to access the QoL and burden of informal caregivers of PwD and identify its associated factors.Methods: Descriptive cross-sectional design with a non-probabilistic and purposive sample of 187 caregivers of PwD. Data collection included the EQ-5D-3L and the Informal Caregiver Burden Assessment Questionnaire (QASCI). Multivariate linear models were estimated to identify determinants of informal caregivers QoL and burden.Results: The results show that the QoL of the informal caregivers was low, and overall burden was found to be moderate. Different explanatory factors were identified for QoL and burden, however, in both cases the familiar relationship and PwD pain/discomfort were identified as potential explanatory factors.Conclusions: Our findings highlight that multiple factors of the informal caregiver and the PwD were correlated with QoL and burden suggesting that the informal care occurs in a complex environment determined by dyads characteristics that together can result in high or low impact for caregiver’s personal life. It is crucial to include informal caregivers as a priority topic regarding dementia health policies, being essential to promote their wellbeing and prevent serious burden, which might also lead to better care and improved QoL for the PwD as well.
Pentraxin 3 as non-invasive biomarker of fibrosis and carotid intima-media thickness in patients with metabolic associated fatty liver disease
Authors: Saad Zienab M , Mostafa Alaa M , Moeness Hend M , Fouad Yasser , Abdel-Raheem Ehab , Osman Nasr M
Published: March 2022

Background: Metabolic-associated fatty liver disease (MAFLD) increases the risk of cardiovascular disease. In this study, we assess the utility of Pentraxin 3 (PTX 3) as a non-invasive predictor of severe fibrosis and carotid intima-media thickness (CIMT) in patients with MAFLD. Methods: 188 patients (114 with MAFLD, 74 with dual aetiology: MAFLD and chronic hepatitis C (CHC) were included. All participants underwent a clinical history and examination, assessment of metabolic parameters, serum level of PTX3, Fib 4 and NFL scores, abdominal ultrasound, and assessment of CIMT. Results: the serum PTX3 was significantly elevated in patients with advanced fibrosis compared with mild/moderate fibrosis ((1.8 vs 1.4, p =0.006). PTX3 level was independently associated with advanced fibrosis (odds ratio [OR] = 1.26, 95% CI 1.008-1.040). In MAFLD, pentraxin 3 level in patients with low fibrosis compared to advanced fibrosis was (1.4 (1-2.1) vs 1.9 (1.3-3.8), p=0.027). A significantly increased CIMT was noted in patients with elevated pentraxin level (3.85 (3.42-4) vs 4.05 (3.7-4.67) p= 0.0001) compared to those with a low level of PTX3. Conclusion: The serum PTX 3 May accurately predicts the presence or absence of advanced fibrosis and CIMT in a MAFLD population. Thus, it could be useful for risk stratification and management.
Novel Gene Signatures Predicting Breast Cancer Based on Random Forest and Artificial Neural Network
Authors: Qiu Yibo , Cheng Long , Wu Huan , Lin Zijing , Ran Haitao , Yang Lu , Wang Yingxiong
Published: March 2022

Background Breast cancer is the most common malignancy in women worldwide, which seriously threatens women's physical and mental health, but currently, there is no classification method for tumor samples based on gene expression profiles for faster breast cancer diagnosis. The study aimed to establish a novel genetic model to distinguish breast cancer patients from the normal population.Results We utilized published expression profiles of breast cancer patients (GSE15852, GSE70905) to identify potential predictive gene panels. A total of 7 differentially expressed genes were identified as predictors. Random forest algorithm and artificial neural network were applied to screen the predictive features and build a model to predict breast cancer. In parallel, we validated this prediction model using expression profiling of a completely independent set of breast cancer patients(GSE70947). The new model was successfully built based on the molecular prognostic scoring system and showed significant predictive value in the training group (AUC = 0.991), which was simultaneously validated in an independent dataset (AUC = 0.817).Conclusions Random forest algorithm combined with artificial neural network successfully constructed a prediction model for breast cancer. The new model can predict breast cancer patients, which is helpful for the diagnosis of breast cancer in the clinic.
TNFAIP6 Defines the MSC Subpopulation with Enhanced Immune Suppression Activities
Authors: Li Lingyun , Chen Xiangjuan , Chen Xian , Yang Lei , Zeng Yong , Xu Jianyong
Published: March 2022

Background: Mesenchymal stem cells (MSCs) have been intensively investigated in both pre-clinical and clinical studies. However, the therapeutic efficacy varies resulting from the heterogenicity of MSCs. Therefore, purifying the specific MSC subpopulation with specialized function is necessary for their therapeutic applications. Methods: The large-scale RNA sequencing analysis was performed to identify potential cell markers for the mouse MSCs. Then the immune suppression activities of the purified MSC subpopulation were assessed in vitro and in vivo. Results: The TNFAIP6 (tumor necrosis factor alpha induced protein 6) has been identified as a potential cell marker for mouse MSCs, irrespective of tissue-origin and lab-origin. The TNFAIP6+ mouse MSCs showed enhanced immune suppression activities and improved therapeutic effects on the mouse model of acute inflammation, resulting from faster response to immune stimulation. Conclusions: Therefore, we have identified TNFAIP6 as a new MSC marker and the TNFAIP6+ MSC subpopulation has enhanced immune suppression capabilities.
Paraneoplastic Hyperthyroidism Secondary to a Chemotherapy-Induced Surge in β-hCG in a Patient with Non-Seminomatous Germ Cell Tumor: Case Report and Literature Review
Authors: Erol Lindsay , Layman Clifton
Published: March 2022

Background: Thyrotoxicosis as the presenting syndrome of an underlying β-hCG-secreting malignancy is well described. It has been previously theorized, but not reported, that the surge of β-hCG secondary to chemotherapy induction may inadvertently trigger thyrotoxicosis. To our knowledge, this is the first documented case of such event in peer-reviewed medical literature published in the English language. Case presentation: We present a case of a 21-year-old male with stage IIIc non-seminomatous germ cell tumor who developed paraneoplastic hyperthyroidism within four days of his first cycle of chemotherapy. Successful treatment of his hyperthyroidism was achieved with methimazole, atenolol and continued treatment of his malignancy. Conclusions: We suggest management considerations based on our case and review of the literature.
Towards real-time probabilistic ash deposition forecasting for Aotearoa New Zealand
Authors: Trancoso Rosa , Behr Yannik , Hurst Tony , Deligne Natalia
Published: March 2022

Volcanic ashfall forecasts are highly dependent on eruption parameters and synoptic weather conditions at the time and location of the eruption. In Aotearoa, New Zealand, MetService and GNS Science have been jointly developing an ashfall forecast system that incorporates 4D high-resolution numerical weather prediction (NWP) and eruption parameters into the HYSPLIT model, a state-of-the art hybrid Eulerian and Lagrangian dispersion model widely used for volcanic ash. However, these forecasts are based on discrete eruption parameters combined with a deterministic weather forecast and thus provide no information on output uncertainty. This shortcoming hinders stakeholder decision making, particularly near the geographical margin of forecasted ashfall and in areas with large gradients in forecasted ash deposition. This study presents a new approach that incorporates uncertainty from both eruptive and meteorologic inputs to deliver uncertainty in the model output. To this end, we developed probabilistic density functions (PDFs) for the three key eruption parameters (plume height, mass eruption rate, eruption duration) tailored to Aotearoa’s volcanoes, and combine them with NWP ensemble datasets to generate probabilistic ashfall forecasts using the HYSPLIT model. We show that the Latin Hypercube Sampling (LHS) technique can be used to representatively span this high-dimensional parameter space with fewer model runs than Monte Carlo techniques, thus allowing this methodology to be used in near real-time forecast systems. We also propose new probabilistic summary products such as hazard matrices, probability of exceedance of cumulative ashfall, and arrival time forecasting, which together support public information and emergency responders decision making.
Chemical investigation and Antibacterial Activity of Leaves Extracts of Artemisia absinthium
Authors: Ewunu Sitotaw , Awoke Sisay , Getachew Mesfin
Published: March 2022

Plants are among the most important common sources of potentially valuable new drugs. Therefore, to investigate biological activity of medicinal plants are used to develop new drugs. Artemisia absinthium L. is an aromatic plant of the family Asteraceae, and is known by the common names wormwood and absinthe. The study of this research was aimed to chemical investigation, essential oil analysis and antibacterial activity of A. absinthium. The plant was collected in different local area of north Wollo, Woldiya. Maceration technique was used for extraction. Isolation of essential oil was done using Cleavinger apparatus. Column chromatography was used to isolate major compounds. In this present study, the major plant secondary metabolites present in A. absinthium was screened, the major constituents the plant was investigated and antibacterial activity of the crude extracts was performed. The results of phytochemical screening showed the presence of alkaloid, flavonoid, carbohydrate, tannin, quinines, protein, phenol and terpenoids. The identified components account for 56% of the oil. The oil contains camphor as a major constituent and account for 41% of the oil. From column chromatography two compounds, chamazulene and davanone were isolated and identified on the bases of their 1H and 13C NMR spectra. Antimicrobial assay of the crude extracts of A. absinthium against gram negative (E. coli and K. pneumonia) and gram positive (L. monocytogen and S. aureus) pathogenic microorganisms showed that a significance activity. Different concentrations of methanol and chloroform were tested and maximum zone of inhibition was found at 200mg/ml in both extracted and zone of inhibition was decreased with decreasing concentrations.
Prevalence of Preterm Premature Rupture of Membrane and Associated Factors Among Pregnant Women Admitted To Health Facilities in Ambotown, Ethiopia, 2021.
Authors: Gutema Rebuma Muleta , Dina Gurmesa Daba , Berhanu Anisa , Erena Maru Mossisa
Published: March 2022

Background: Preterm pre-labor rupture of the membrane is a major cause of perinatal, neonatal, and maternal morbidity and mortality both in high- and low-income countries. A woman with premature rupture of membranes is at risk of complications like intra-amniotic infection, postpartum hemorrhage, and death. Little is known about the problem in the study area, therefore, this study was designed to determine the prevalence of preterm premature rupture of membrane and its associated factors among pregnant women admitted to health facilities in ambo town. Methods: Hospitals based cross sectional study was conducted on 391 pregnant women who were admitted to the Hospitals in Ambo town from July 05/2021-August 30/2021.The data were collected through face-to-face interviews by a structured questionnaire. Descriptive analyses were performed using frequencies, percentages, binary logistic regression by adjusting for confounding factors.Results: The prevalence of preterm premature rupture of membrane was found to be 22.6%. Preeclampsia (AOR=3.2, 95% CI=0.69-0.57), Economic status (AOR = 2.64 (95% CI = 1.99–6.01), current urinary tract infection (AOR = 2.42, 95% CI = 1.32–5.19), previous history of premature rupture of membrane (AOR = 2.31, 95% CI = 1.02–6.27), andanemia (AOR = 1.85, 95% CI = 0.65–4.56) were factors associated with preterm premature rupture of membrane.Conclusions: The prevalence of preterm premature rupture of membrane in the study area was high. Based on the predisposing factors identifiedearly screening and treatment as well as health promotion isimportant to reduce the risk of preterm premature rupture of membrane.
Factors Leading to Disruptive Behaviours Involving Radiographers: A Qualitative Study
Authors: Chinene Bornface , Nkosi Busisiwe Pauline , Sibiya Maureen Nokuthula
Published: March 2022

Background
The negative consequences of disruptive behaviours involving healthcare workers threatens the institution’s image, staff morale, finances, and patient safety. While all kinds of health organisations or settings are potentially exposed to disruptive behaviours, some are at higher risk than others because of both environmental and cultural factors. Such risk should be assessed having regard to the specific situation and conditions in which each healthcare organization operates. International regulatory best-practice standards now require healthcare institutions to develop policies and plans at specific workplaces to combat DBs and establish the required monitoring mechanisms and a range of sanctions. The purpose of this study was to explore the environmental and cultural factors leading to DBs involving radiographers at central hospitals in Harare Metropolitan Province so that tailor-made strategies for addressing these behaviours can be formulated.
Methods
An exploratory qualitative study employing face to face, one-on-one in-depth interviews was carried out between March and April 2021. Eleven radiography managers at central hospitals in Harare Metropolitan Province (HMP) were selected by criterion purposive sampling. The interview data were analysed using Tesch's method of qualitative analysis. The data was first manually coded and then entered into Nvivo (QSR International Version 11) for further analysis. This study was assessed using the four criteria for developing the trustworthiness of qualitative research as suggested by Lincoln and Guba, namely credibility, dependability, conformability and transferability.
Results
The key environmental and cultural factors identified included three themes: power hierarchy, work environment and reporting framework. Power hierarchy comprised categories, superiority, professional boundaries and representation. The work environment incorporated categories, trust in leadership, burnout and fatigue and remuneration. Lastly, reporting framework included categories, lack of protocol and reporting culture.
Conclusions
This study highlights that environmental factors play a bigger role in provoking disruptive behaviours involving radiographers at central hospitals in HMP. This underscores the need for hospital and radiography managers to pay particular emphasis on these when formulating policies and procedures to address these behaviours. Addressing DBs ensures that healthy work environments are promoted which in turn ensures that patients receive optimum and safe care.
Periostin overexpression in scleroderma cardiac tissue and its utility as a marker for disease complications
Authors: El-Adili Fatima , Lui Justin K. , Najem Mortada , Farina Giuseppina , Trojanowska Maria , Sam Flora , Bujor Andreea M.
Published: March 2022

Objective
To evaluate the levels of periostin in patients with systemic sclerosis (SSc) and their association with features of systemic sclerosis.
Methods
The levels of periostin were assessed in the serum of 106 SSc patients and 14 healthy controls, and by immunofluorescence staining in cardiac tissue from 4 SSc patients and 4 healthy controls. Serum periostin was measured via enzyme-linked immunosorbent assay, and the natural logarithm of periostin (log-periostin) was calculated. Results were analyzed using unpaired t-test or one-way ANOVA followed by Tukey’s multiple comparisons tests, and Pearson’s test for correlations. Cardiac tissue from SSc patients and controls was stained for periostin and co-stained for periostin and collagen type I using immunofluorescence.
Results
Periostin levels were higher in patients with SSc compared to controls, and directly correlated to modified Rodnan skin score and echocardiography parameters of left ventricular measurements. Immunofluorescence staining in SSc cardiac tissue showed patchy periostin expression in all SSc patients, but not in controls. Furthermore, there was extensive periostin expression even in areas without collagen deposition, while all established fibrotic areas showed co-localization of collagen and periostin. There was no association between periostin levels and interstitial lung disease, pulmonary hypertension or other vascular complications.
Conclusion
Periostin is elevated in SSc cardiac tissue in vivo and circulating levels of periostin are increased in SSc, correlating with the extent of disease duration, degree of skin fibrosis, and left ventricular structural assessments. Periostin may be a potential biomarker that can provide further pathogenic insight into cardiac fibrosis in SSc.