bluuebunny/crossref_metadata_2025 huggingface dataset:
Time Trends of Ventricular Reconstruction and Outcomes among Patients with Left Ventricular Thrombus and Aneurysms
Authors: Shi Boqun , Tiemuerniyazi Xieraili , Zhang Rui , Song Chenxi , Cui Kongyong , Zhang Dong , Jia Lei , Yin Dong , Wang Hongjian , Song Weihua , Feng Wei , Dou Kefei
Published: December 2022

Background: Clinical guidelines recommend surgical intervention when left ventricular thrombus (LVT) is complicated with left ventricular aneurysm (LVA). Objectives: This study aimed to review the changes in the treatment of LVT combined with LVA over the past 12 years at our center and to compare the efficacy of medical therapy and surgical treatment on patient outcomes. Methods: Between January 2009 and June 2021, 723 patients with LVT combined with LVA were enrolled, of whom 205 received surgical ventricular reconstruction (SVR) therapy and 518 received medical therapy. The following clinical outcomes were gathered via observation: all-cause death, cardiovascular death, and major adverse cardiovascular and cerebrovascular events (MACCEs; defined as the composite of cardiovascular death, ischemic stroke, and acute myocardial infarction). The median follow-up time was 1403 [707, 2402] days. Results: The proportion of SVR dropped yearly in this group of patients, from a peak of 64.5% in 2010 to 7.5% in 2021 (p for trend < 0.001). Meanwhile, the proportion of anticoagulant use increased quickly, from 8.0% in 2016 to 67.9% in 2021 (p for trend < 0.001). The incidence rates of all-cause mortality, cardiovascular death, and MACCEs were 12.9% (n = 93), 10.5% (n = 76), and 14.7% (n = 106), respectively. In the multivariable analysis, there were no significant differences in all-cause death (HR of 0.60, 95% CI of 0.32–1.13, p = 0.11), cardiovascular death (HR of 0.79, 95% CI of 0.41–1.50, p = 0.5), and MACCEs (HR of 0.82, 95% CI of 0.49–1.38, p = 0.5) between the two groups. The competing risk regression performed in the propensity score matching (PSM) and inverse probability of treatment weighting (IPTW) analyses was in line with the unmatched analysis. Conclusions: The rate of SVR dropped significantly among patients with both LVT and LVA, while there was an improvement in oral anticoagulant utilization. SVR with thrombus removal did not improve all-cause mortality and cardiovascular outcomes in patients with LVT and LVA. Ventricular aneurysm with thrombus may not be an indication for surgery.
Design Features and Simulation of the New-Build HELOKA-US Facility for the Validation of the DEMO Helium-Cooled Pebble Bed Intermediate Heat Transport and Storage System
Authors: Gaus-Liu Xiaoyang , Bubelis Evaldas , Perez-Martin Sara , Ghidersa Bradut-Eugen , Hering Wolfgang
Published: December 2022

For the EU-DEMO Helium-Cooled Pebble Bed (HCPB) concept, an indirect coupled design (ICD) with a molten salt (MS) loop as an intermediate heat transport and storage system (IHTS) is considered for the conceptual design phase. The IHTS with an energy storage decouples the primary heat transport system (PHTS) that undergoes pulse and dwell power cycles from the power conversion system (PCS), and thus can provide stable power to the turbine and grid. However, the maintenance of stable He and MS parameters during transitions from dwell to pulse and vice versa is challenging for the design of the MS loop, and the real performance of the helium–MS heat exchanger (He/MS HX) shall be verified. To investigate such components and conditions, a new R&D infrastructure HELOKA-US (Helium Loop Karlsruhe—Upgrade Storage) is under construction for the validation of prototypical components and the MS loop operation under stationary and transitional conditions. This paper provides the design features of Phase 1a of the project and the simulation results with EBSILON on the power generation phase.
Two New Species and a New Record of Microdochium from Grasses in Yunnan Province, South-West China
Authors: Gao Ying , Ren Guang-Cong , Wanasinghe Dhanushka N. , Xu Jian-Chu , Gomes de Farias Antonio Roberto , Gui Heng
Published: December 2022

Microdochium species are frequently reported as phytopathogens on various plants and also as saprobic and soil-inhabiting organisms. As a pathogen, they mainly affect grasses and cereals, causing severe disease in economically valuable crops, resulting in reduced yield and, thus, economic loss. Numerous asexual Microdochium species have been described and reported as hyphomycetous. However, the sexual morph is not often found. The main purpose of this study was to describe and illustrate two new species and a new record of Microdochium based on morphological characterization and multi-locus phylogenetic analyses. Surveys of both asexual and sexual morph specimens were conducted from March to June 2021 in Yunnan Province, China. Here, we introduce Microdochium graminearum and M. shilinense, from dead herbaceous stems of grasses and report M. bolleyi as an endophyte of Setaria parviflora leaves. This study improves the understanding of Microdochium species on monocotyledonous flowering plants in East Asia. A summary of the morphological characteristics of the genus and detailed references are provided for use in future research.
The Effect of IFRS Adoption on the Business Climate: A Country Perspective
Authors: Penela Daniela , Estevão João , Morais Ana Isabel
Published: December 2022

Based on the ten areas that are measured by the ease of doing business (EDB) and based on the getting credit (GC) indicator, this study seeks to analyze factors that lead to a more favorable business climate in different countries. The methodology of fuzzy-set qualitative comparative analysis (fsQCA) was used to determine the paths taken by configurations or conditions in which variables affect an outcome. The results showed that high EDB and GC scores may be obtained under specified levels of IFRS (International Financial Reporting Standards) adoption degree and user experience requirements. Therefore, the adoption of IFRS could result in a better business climate in a nation since it would increase the comparability of financial statements, which will lower costs for investors, draw in foreign investors, and boost trust. Finally, the findings indicated that, depending on the presence of specific levels of GDP per capita, entrepreneurship, income group, and foreign direct investment (FDI) inflows, low or high values of IFRS adoption and high experience in applying IFRS are necessary to achieve high GC scores.
Is Professional Soccer a Risk for Their “Lives Afterwards”? A Social-Sciences-Based Examination of Retired Professional Soccer Players from a Long-Term Perspective
Authors: Barth Michael , Schlesinger Torsten , Pitsch Werner
Published: December 2022

Most professional soccer players’ careers end before their forties. Consequently, many of them face a relatively early retirement from their profession, thus facing multifaceted changes and potential issues of adjustments in different areas of their lives. Public discussion and therein expressed concerns have led to increased attention on the topic, notably among practitioners and researchers. This study described and analyzed central retirement transition and adjustment outcomes of ex-professional soccer players from a social sciences and long-term perspective. A total of 78 ex-professionals completed the online questionnaire, most of them having played in the highest German soccer division for several years and having retired from professional soccer 10 years or more ago. Overall, 8.9% (95% CI 2.5 to 21.2; n = 45) showed signs of mental health problems. Compared to the results of a gender- and age-matched sample from the German population, retired ex-professionals were significantly more satisfied with their life and their personal income, and assessed themselves as having a higher subjective social status. Although further evidence is necessary to draw any final conclusion, our results do not point to those publicly discussed concerning central retirement transition and adjustment outcomes of (average) former professional soccer players in the long run.
A Comparative Analysis of Drivers Impacting Urban Densification for Cross Regional Scenarios in Brussels Metropolitan Area
Authors: Chakraborty Anasua , Omrani Hichem , Teller Jacques
Published: December 2022

Our research aims at unveiling the various drivers that can have an impact on urban densification. Unlike the usual logistic modelling techniques, our study considers multi-level built-up densities ranging from low to high built-up density. The commonly used dataset for a number of present studies is based on raster images. Our study uses vector-based cadastral data to create maps for the years 2000, 2010 and 2020 in order to better trace densification. Furthermore, our study addresses the situation of a metropolitan area, Brussels, that spreads over three different regions that are developing independent land-planning policies. Since the state reform of 1993, Belgium has undergone a significant political transformation with a decentralization of land-planning policies from the state level to regional authorities. This reform allowed a progressive divergence of planning policies between the three regions, i.e., Flanders, the Brussels Capital Region and Wallonia. According to our findings, all the controlling factors exhibit distinct variation over all their density classes for the three regions. This may be due to differences in socioeconomic, territorial, and regulatory factors. For Flanders and the Brussels Capital Region, slope and distance to roadways are the most significant drivers explaining densification, whereas densification in Wallonia is predominantly influenced by land-use policies, especially the zoning regime. These results highlight the impact of considering cross-regional divergences in the implementation of planning policies at the metropolitan level, especially in those metropolitan areas that are expanding into different regions with divergent planning policies.
Amentoflavone-Enriched Selaginella rossii Protects against Ultraviolet- and Oxidative Stress-Induced Aging in Skin Cells
Authors: Lee Hwa , Kim Soo-Yong , Lee Sang Woo , Kwak Sehan , Li Hulin , Piao Renzhe , Park Ho-Yong , Choi Sangho , Jeong Tae-Sook
Published: December 2022

Selaginellaceae plants are used in cosmetics to limit skin aging. This study is the first to investigate the anti-aging effects of Selaginella rossii (SR) on ultraviolet B (UVB)- and oxidative stress-induced skin cells. The 95% ethanol extract of Selaginella rossii (SR95E) contained much higher amounts of amentoflavone (AMF), an active compound, than other Selaginellaceae plants and was more effective in inhibiting matrix metalloproteinase (MMP)-1 expression in CCD-986sk fibroblasts. SR95E significantly decreased UVB-induced MMP-1, MMP-2, MMP-3 and MMP-9 expression and enhanced procollagen type I C-peptide content and mRNA expression of collagen type I alpha (COL1A)1 and COL1A2 in CCD-986sk fibroblasts. In HaCaT keratinocytes, SR95E treatment also dose-dependently decreased UVB-induced MMP-1 concentration and MMP-1, MMP-2, MMP-3 and MMP-9 mRNA expression. Moreover, SR95E treatment markedly inhibited UVB-induced c-Jun N-terminal kinase and p38 mitogen-activated protein kinase signaling and nuclear factor kappa-B signaling in HaCaT cells. Furthermore, SR95E and AMF markedly regulated the 2,2′-azobis(2-amidinopropane) dihydrochloride (AAPH)-induced expression of cellular senescence-related markers, including p16, p21 and LMNB1, in HaCaT cells. Overall, this study indicates that SR may have potential as a functional material on preventing UVB- and AAPH-induced skin aging and wrinkles.
Mechanisms and Effects of Isorhamnetin on Imiquimod-Induced Psoriasiform Dermatitis in Mice
Authors: Wu Chieh-Shan , Lin Chuan-Chao , Chen Yu-Ying , Yang Deng-Ho
Published: December 2022

Isorhamnetin (IRh), which has a wide range of pharmacological effects, is one of the most significant active components in the fruits of Hippophae rhamnoides L. and the leaves of Ginkgo biloba L. It protects the heart and brain, in addition to possessing anti-tumor, anti-inflammatory, antioxidant, organ protection, and anti-obesity properties. We sought to assess IRh’s anti-psoriatic activity, explore its immunomodulatory properties in reducing the severity of psoriatic symptoms, and evaluate its potential immunotherapeutic effects. We used IRh to treat imiquimod (IMQ)-induced psoriasis in BALB/C mice and examined the underlying mechanisms. The outcomes demonstrated that IRh reduced epidermal hyperplasia, lowered PASI scores, and improved histopathological psoriasiform lesions in IMQ-induced mice. IRh attenuated the accumulation of malondialdehyde (MDA), and also reversed the reduction caused by IMQ of superoxide dismutase (SOD) and catalase (CAT) in skin tissues. Additionally, IRh effectively inhibited IMQ’s ability to increase proinflammatory cytokines such as TNF-α, IL-6, IL-17A, and transcription factor NF-κB. Furthermore, IRh significantly reduced the percentage of Th1 and Th17 in the spleens of mice treated with IMQ and suppressed the maturation of splenic dendritic cells. Overall, our research suggests that IRh protects against oxidative stress and inflammation in the pathogenesis of psoriasis, with potential for the development of new and potent medication for the treatment of psoriasis.
Sleep Endoscopy with Positive Airway Pressure: A Method for Better Compliance and Individualized Treatment of Patients with Obstructive Sleep Apnea
Authors: Masárová Michaela , Matoušek Petr , Jor Ondřej , Novák Vilém , Vrtková Adéla , Kubec Vojtěch , Zeleník Karol , Komínek Pavel , Formánek Martin
Published: December 2022

In this study, we aimed to observe the effects of positive airway pressure (PAP) on individual levels of obstruction during drug-induced sleep endoscopy (DISE) of the upper airways (UA), to evaluate at which pressures the obstruction disappeared or worsened, and to identify cases in which PAP was ineffective. This prospective study was conducted from June 2018 to June 2022. PAP testing was performed during DISE in patients with moderate and severe OSA. The pressure was gradually increased over the range from 6.0 to 18.0 hPa. Our findings were evaluated using the VOTE classification. The examination was performed in 56 patients, with a median apnea–hypopnea index (AHI) of 26.4. Complete obstruction of the soft palate was observed in 51/56 patients (91%), oropharyngeal obstruction in 15/56 patients (27%), tongue base obstruction in 23/56 patients (41%), and epiglottic collapse in 16/56 patients (29%). PAP was most effective in cases of complete oropharyngeal obstruction, and least effective in cases of epiglottic collapse, where it was ineffective in 11/16 patients. DISE with PAP is a simple diagnostic method that can be helpful for identifying anatomic and dynamic reasons for PAP intolerance. The main indication is ineffective PAP treatment.
Time-Course of Redox Status, Redox-Related, and Mitochondrial-Dynamics-Related Gene Expression after an Acute Bout of Different Physical Exercise Protocols
Authors: Pires Ramon Alves , Correia Thiago Macedo Lopes , Almeida Amanda Alves , Coqueiro Raildo da Silva , Machado Marco , Teles Mauro Fernandes , Peixoto Álbert Souza , Queiroz Raphael Ferreira , Pereira Rafael
Published: December 2022

We investigated the magnitude of exercise-induced changes in muscular bioenergetics, redox balance, mitochondrial function, and gene expression within 24 h after the exercise bouts performed with different intensities, durations, and execution modes (continuous or with intervals). Sixty-five male Swiss mice were divided into four groups: one control (n = 5) and three experimental groups (20 animals/group), submitted to a forced swimming bout with an additional load (% of animal weight): low-intensity continuous (LIC), high-intensity continuous (HIC), and high-intensity interval (HII). Five animals from each group were euthanized at 0 h, 6 h, 12 h, and 24 h postexercise. Gastrocnemius muscle was removed to analyze the expression of genes involved in mitochondrial biogenesis (Ppargc1a), fusion (Mfn2), fission (Dnm1L), and mitophagy (Park2), as well as inflammation (Nos2) and antioxidant defense (Nfe2l2, GPx1). Lipid peroxidation (TBARS), total peroxidase, glutathione peroxidase (GPx), and citrate synthase (CS) activity were also measured. Lactacidemia was measured from a blood sample obtained immediately postexercise. Lactacidemia was higher the higher the exercise intensity (LIC < HIC < HII), while the inverse was observed for TBARS levels. The CS activity was higher in the HII group than the other groups. The antioxidant activity was higher 24 h postexercise in all groups compared to the control and greater in the HII group than the LIC and HIC groups. The gene expression profile exhibited a particular profile for each exercise protocol, but with some similarities between the LIC and HII groups. Taken together, these results suggest that the intervals applied to high-intensity exercise seem to minimize the signs of oxidative damage and drive the mitochondrial dynamics to maintain the mitochondrial network, similar to low-intensity continuous exercise.
Experimental Study on Variable-Amplitude Fatigue Performance of M60 High-Strength Bolts of Grid Structures with Bolted Spherical Joints
Authors: Zhou Zichun , Zhang Shujia , Lei Honggang , Qiu Bin , Zhang Liang , Wang Guoqing
Published: December 2022

The high-strength bolts of grid structures with bolted spherical joints under the action of suspension cranes are at risk of severe fatigue failure. Thus, this paper studies the variable-amplitude fatigue performance of M60 high-strength bolts. The test results for eight specimens in four loading modes are obtained using an Amsler fatigue testing machine. The fatigue life is also estimated based on Miner and Corten–Dolan’s theories, and the applicability of Corten–Dolan’s theory is verified. The fracture induced by the variable-amplitude fatigue is microscopically analyzed using scanning electron microscopy (SEM), revealing the mechanism of the variable-amplitude fatigue failure. Our findings provide valuable experimental data supporting the fatigue life estimation of grid structures with bolted spherical joints in service.
Marshall Stability Prediction with Glass and Carbon Fiber Modified Asphalt Mix Using Machine Learning Techniques
Authors: Upadhya Ankita , Thakur Mohindra Singh , Al Ansari Mohammed Saleh , Malik Mohammad Abdul , Alahmadi Ahmad Aziz , Alwetaishi Mamdooh , Alzaed Ali Nasser
Published: December 2022

Pavement design is a long-term structural analysis that is required to distribute traffic loads throughout all road levels. To construct roads for rising traffic volumes while preserving natural resources and materials, a better knowledge of road paving materials is required. The current study focused on the prediction of Marshall stability of asphalt mixes constituted of glass, carbon, and glass-carbon combination fibers to exploit the best potential of the hybrid asphalt mix by applying five machine learning models, i.e., artificial neural networks, Gaussian processes, M5P, random tree, and multiple linear regression model and further determined the optimum model suitable for prediction of the Marshall stability in hybrid asphalt mixes. It was equally important to determine the suitability of each mix for flexible pavements. Five types of asphalt mixes, i.e., glass fiber asphalt mix, carbon fiber asphalt mix, and three modified asphalt mixes of glass-carbon fiber combination in the proportions of 75:25, 50:50, and 25:75 were utilized in the investigation. To measure the efficiency of the applied models, five statistical indices, i.e., coefficient of correlation, mean absolute error, root mean square error, relative absolute error, and root relative squared error were used in machine learning models. The results indicated that the artificial neural network outperformed other models in predicting the Marshall stability of modified asphalt mix with a higher value of the coefficient of correlation (0.8392), R2 (0.7042), a lower mean absolute error value (1.4996), and root mean square error value (1.8315) in the testing stage with small error band and provided the best optimal fit. Results of the feature importance analysis showed that the first five input variables, i.e., carbon fiber diameter, bitumen content, hybrid asphalt mix of glass-carbon fiber at 75:25 percent, carbon fiber content, and hybrid asphalt mix of glass-carbon fiber at 50:50 percent, are highly sensitive parameters which influence the Marshall strength of the modified asphalt mixes to a greater extent.
Experimental Investigation on the Formability of Al-Mg Alloy 5052 Sheet by Tensile and Cupping Test
Authors: He Hongmei , Yang Tao , Ren Yi , Peng Yi , Xue Song , Zheng Lixuan
Published: December 2022

Aiming at the enhancement of the lightweight formability potential of aluminum alloy, the bulging and tensile properties of a 5052 Aluminum alloy sheet were tested on a microcomputer controlled sheet metal forming tester and tensile testing machine. The effects of different blank holder force, punch velocity and lubrication conditions were investigated on bulging properties by the experimental analysis. The cupping values (Erichsen Cupping Index: IE) of sheets with a thickness of 1.2 mm at room temperature were obtained under different process parameters. Meanwhile, the anisotropic property of the material was analyzed in different rolling directions. The results show that the sheet cupping values increase with the increase of blank holder force and punch velocity, and the stress state was changed due to the changing of the blank holder force and strain rate. Moreover, the use of lubricating conditions with a lower coefficient of friction allows the sheet to exhibit a larger cupping value. The effect of rolling direction on the anisotropy of 5052 aluminum alloy sheet is distinct, which means in the aluminum alloy sheet forming process the anisotropy factor should be carefully considered.
Correction: Cakir, M.; Gunes, B. A Fitted Operator Finite Difference Approximation for Singularly Perturbed Volterra-Fredholm Integro-Differential Equations. Mathematics 2022, 10, 3560
Authors: Cakir Musa , Gunes Baransel
Published: December 2022

The authors wish to make the following corrections to this paper [...]
Solution of an Electrodynamic Problem for a Homogeneous Equivalent Segment of a Coaxial Load, Considering Heat Losses in the Conductors
Authors: Tatarenko Polina V. , Tatarenko Alexander S.
Published: December 2022

Mathematical aspects of solving an electrodynamic problem in the field of designing coaxial devices in the microwave range are considered. The solution of the electrodynamic problem for a homogeneous equivalent segment of a coaxial load in the single-mode approximation, considering the heat losses in the central and outer conductors, was obtained. A mathematical model of the microwave load, linking the high-frequency and design-technological parameters of the device, was built. To refine the model, we consider second-order effects associated with considering inhomogeneities that occur in places where the cross-section of the coaxial structure changes. The design of the 50-Ω load and the results of its experimental investigation are presented for comparison with theoretical calculations.
Computational Analysis of the Magnetized Second Grade Fluid Flow Using Modified Fourier and Fick’s Law towards an Exponentially Stretching Sheet
Authors: Nabwey Hossam A. , Khan Aamir Abbas , Ashraf Muhammad , Rashad Ahmad M. , Alshber Sumayyah I. , Abu Hawsah Miad
Published: December 2022

Numerical investigation of a chemically reactive second grade fluid flow towards an exponentially stretching sheet into a porous medium induced by thermal and concentration slips boundary conditions is carried out. Further, nonlinear thermal radiations, Joule heating, MHD and thermophoretic impacts are also taken into account. The modified Fourier and Fick’s law is used to analyse the thermal and solutal energy features. The nonlinear systems of partial differential equations, as well as boundary conditions, are transformed into systems of nonlinear ordinary differential equations by imposing appropriate similarity variables. Then these transformed equations are solved using the BVP4C Matlab approach numerically. The graphs and tables of a number of emerging parameters are plotted and discussed. It is noticed that by the improvement of the second grade fluid parameter, the velocity profile is reduced. Moreover, the upsurge of Eckert numbers Ec1 and Ec2 and thermal slip parameter S1 enhance the temperature of the fluid in the flow domain.
Performance Analysis of Feature Subset Selection Techniques for Intrusion Detection
Authors: Almaghthawi Yousef , Ahmad Iftikhar , Alsaadi Fawaz E.
Published: December 2022

An intrusion detection system is one of the main defense lines used to provide security to data, information, and computer networks. The problems of this security system are the increased processing time, high false alarm rate, and low detection rate that occur due to the large amount of data containing various irrelevant and redundant features. Therefore, feature selection can solve this problem by reducing the number of features. Choosing appropriate feature selection methods that can reduce the number of features without a negative effect on the classification accuracy is a major challenge. This challenge motivated us to investigate the application of different wrapper feature selection techniques in intrusion detection. The performance of the selected techniques, such as the genetic algorithm (GA), sequential forward selection (SFS), and sequential backward selection (SBS), were analyzed, addressed, and compared to the existing techniques. The efficiency of the three feature selection techniques with two classification methods, including support vector machine (SVM) and multi perceptron (MLP), was compared. The CICIDS2017, CSE-CIC-IDS218, and NSL-KDD datasets were considered for the experiments. The efficiency of the proposed models was proved in the experimental results, which indicated that it had highest accuracy in the selected datasets.
Local Well-Posedness for the Magnetohydrodynamics in the Different Two Liquids Case
Authors: Frolova Elena , Shibata Yoshihiro
Published: December 2022

We consider the free boundary problem of MHD in the multi-dimensional case. This problem describes the motion of two incompressible fluids separated by a closed interface under the action of a magnetic field. This problem is overdetermined, and we find an equivalent system of equations which is uniquely solvable locally in time in the Lp-Lq maximal regularity class, where 1<p,q<∞ and 2/p+N/q<1. As a result, the original two-phase problem for the MHD is solvable locally in time.
Deep Convolutional Neural Network for Detection and Prediction of Waxy Corn Seed Viability Using Hyperspectral Reflectance Imaging
Authors: Zhao Xiaoqing , Pang Lei , Wang Lianming , Men Sen , Yan Lei
Published: December 2022

This paper aimed to combine hyperspectral imaging (378–1042 nm) and a deep convolutional neural network (DCNN) to rapidly and non-destructively detect and predict the viability of waxy corn seeds. Different viability levels were set by artificial aging (aging: 0 d, 3 d, 6 d, and 9 d), and spectral data for the first 10 h of seed germination were continuously collected. Bands that were significantly correlated (SC) with moisture, protein, starch, and fat content in the seeds were selected, and another optimal combination was extracted using a successive projection algorithm (SPA). The support vector machine (SVM), k-nearest neighbor (KNN), random forest (RF), and deep convolutional neural network (DCNN) approaches were used to establish the viability detection and prediction models. During detection, with the addition of different levels, the recognition effect of the first three methods decreased, while the DCNN method remained relatively stable (always above 95%). When using the previous 2.5 h data, the prediction accuracy rate was generally higher than the detection model. Among them, SVM + full band increased the most, while DCNN + full band was the highest, reaching 98.83% accuracy. These results indicate that the combined use of hyperspectral imaging technology and the DCNN method is more conducive to the rapid detection and prediction of seed viability.
Albumin-Bilirubin Grade as a Novel Predictor of the Development and Short-Term Survival of Post-Banding Ulcer Bleeding Following Endoscopic Variceal Ligation in Cirrhotic Patients
Authors: Chen Chun-Wei , Kuo Chia-Jung , Lee Chao-Wei , Kuo Tony , Chiu Cheng-Tang , Lin Chun-Jung , Lim Siew-Na , Yeh Chau-Ting , Lin Wey-Ran
Published: December 2022

Background and Objectives: Endoscopic variceal ligation (EVL) is the primary and secondary treatment for acute esophageal variceal bleeding. Post-banding ulcer bleeding (PBUB) may lead to bleeding episodes following EVL, increasing mortality. The aim of this study was to evaluate the risk factors for PBUB and predict the 6-week mortality risk after PBUB. Materials and Methods: We retrospectively analyzed the data collected from cirrhotic patients with EVL from 2015 to 2017. The incidence of PBUB and the 6-week mortality rate were evaluated. Risk factors for PBUB and predictive factors for mortality after PBUB were analyzed. Results: A total of 713 patients were enrolled in this study. Among the studied subjects, the incidence of PBUB was 5.8% (N = 41). The 6-week mortality rate was 63.4% (26/41). In multivariate analysis, MELD score ≥20 (OR: 3.77, 95% CI: 1.94–7.33, p < 0.001), ALBI score of 3 (OR: 2.67, 95% CI: 1.34–5.3, p = 0.005) and the presence of gastric varices (OR: 2.1, 95% CI: 1.06–4.16, p = 0.03) were associated with the development of PBUB. Patients with ALBI grade 3 (OR: 4.8, 95% CI: 1.18–19.6, p = 0.029) and Child-Pugh scores B and C (OR: 16.67, 95% CI: 1.75–158.1, p = 0.014) were associated with 6-week mortality after PBUB. Conclusions: PBUB is a complication with low incidence but increased mortality following EVL. The ALBI grade is a useful score to predict not only the development of PBUB but also the 6-week mortality after PBUB.
Platelet-Rich Plasma for Pleurodesis: An Experimental Study in Rabbits
Authors: Kolokotroni Styliani Maria , Lamprinos Dimitrios , Goutas Nikolaos , Kapetanakis Emmanouil I. , Kontzoglou Konstantinos , Perrea Despoina , Tomos Periklis
Published: December 2022

Background and Objectives: This study was designed to evaluate platelet-rich plasma (PRP) as a method of pleurodesis in a rabbit model. Pleurodesis with PRP was compared against the gold-standard use of talc. The secondary evaluation assessed the ideal time for achieving pleurodesis. Materials and Methods: 25 healthy New Zealand white rabbits were assigned to three groups, as follows: 12 animals in the first and second groups, as well as one animal with no intervention in the final group, which was used as a control. The talc pleurodesis group (baseline) underwent pleurodesis with sterile talc, which is the gold-standard sclerosing agent used for pleurodesis. The PRP group underwent pleurodesis using autologous PRP. The last group had one rabbit with no intervention. A total of 12 rabbits (n = 6 for the talc pleurodesis group and n = 6 for the PRP group) were sacrificed 3 days (72 h) after the intervention, and 12 rabbits (n = 6 for the talc pleurodesis group and n = 6 for the PRP group) were sacrificed 6 days (144 h) after the intervention. In both the talc and PRP group, FBC and CRP were measured before the intervention and in 3 or 6 days afterwards, respectively. The pleura and the lungs were evaluated histopathologically. Results: Macroscopically, there were no statistically significant differences between the two groups. In terms of microscopic findings, there were no statistically significant differences in inflammatory reactions provoked in the visceral and parietal pleura between the PRP and talc. In addition, with talc pleurodesis, a foreign-body reaction was observed in about 50% of the cases, which was not observed with PRP. In terms of inflammation between 3 and 6 days, there were no statistically significant differences with PRP, there was only a statistically significant difference between 3 and 6 days regarding the parietal pleura in the talc group. Conclusions: The instillation of autologous PRP in the pleural cavity shows promise in achieving pleurodesis. The efficacy of PRP as a pleurodesis agent should be examined further.
Resurgence of Electron Quantum Tunneling Sensors
Authors: Banerjee Aishwaryadev , Mastrangelo Carlos H.
Published: December 2022

Quantum tunneling sensors are typically ultra-sensitive devices that have been specifically designed to convert a stimulus into an electronic signal using the wondrous principles of quantum mechanical tunneling. In the early 1990s, William Kaiser developed one of the first micromachined quantum tunneling sensors as part of his work with the NASA Jet Propulsion Laboratory. Since then, there have been scattered attempts at utilizing this phenomenon for the development of a variety of physical and chemical sensors. Although these devices demonstrate unique characteristics, such as high sensitivity, the principle of quantum tunneling often acts as a double-edged sword and is responsible for certain drawbacks of this sensor family. In this review, we briefly explain the underlying working principles of quantum tunneling and how they are used to design miniaturized quantum tunneling sensors. We then proceed to describe an overview of the various attempts at developing such sensors. Next, we discuss their current necessity and recent resurgence. Finally, we describe various advantages and shortcomings of these sensors and end this review with an insight into the potential of this technology and prospects.
Fungal Zinc Homeostasis and Its Potential as an Antifungal Target: A Focus on the Human Pathogen Aspergillus fumigatus
Authors: Zhai Pengfei , Chai Yanfei , Lu Ling
Published: December 2022

Aspergillus fumigatus is an opportunistic airborne fungus that causes severe invasive aspergillosis in immunocompromised patients. Zinc is an essential micronutrient for the growth of A. fumigatus and even for all microorganisms. An increasing number of studies have reported that fungal zinc acquisition ability plays a key role in fungal survival in hosts with an extremely zinc-limited microenvironment. The ability to fight scarcity and excess of zinc are tightly related to fungal virulence and may be used as new potential targets. Because the regulation of zinc homeostasis is important, a thorough understanding of the functional genes involved in the regulatory network for zinc homeostasis is required for fungal pathogens. The current mini-review summarized potential zinc homeostasis regulators in A. fumigatus and classified these regulators according to localization and function, which were identified or predicted based on A. fumigatus or deduced from homologs in model yeasts. Future perspectives for zinc homeostasis regulators as potential antifungal targets to treat invasive aspergillosis are also discussed.
FTIR as a Method for Qualitative Assessment of Solid Samples in Geochemical Research: A Review
Authors: Tkachenko Yana , Niedzielski Przemysław
Published: December 2022

This study aims to collect information about soil investigation by FTIR. As we know, the FTIR technique is most often used in organic and bioorganic chemistry, while in geochemistry FTIR spectroscopy is not used very often. Therefore, there is a problem with the identification and interpretation of the IR spectra of minerals contained in sediments and soils. The reason for this is a deficiency of data about characteristic wavenumbers for minerals. Therefore, this study reviews and sums up, in one place, published articles that are connected to an investigation of minerals from 2002 to 2021 (based on the Scopus database). Additionally, the present review highlights various analytical techniques (ATR-FTIR, DRIFT, 2D-IR, and SR-FTIR) and discusses some of them for geochemical study. Additionally, the study describes helpful tools in the data pre-processing of IR spectra (normalization, baseline correction, and spectral derivatives).
Application of Nanomaterials to Enhance Polymerase Chain Reaction
Authors: Yang Zhu , Shen Bei , Yue Lihuan , Miao Yuqing , Hu Yihong , Ouyang Ruizhuo
Published: December 2022

Polymerase Chain Reaction (PCR) is one of the most common technologies used to produce millions of copies of targeted nucleic acid in vitro and has become an indispensable technique in molecular biology. However, it suffers from low efficiency and specificity problems, false positive results, and so on. Although many conditions can be optimized to increase PCR yield, such as the magnesium ion concentration, the DNA polymerases, the number of cycles, and so on, they are not all-purpose and the optimization can be case dependent. Nano-sized materials offer a possible solution to improve both the quality and productivity of PCR. In the last two decades, nanoparticles (NPs) have attracted significant attention and gradually penetrated the field of life sciences because of their unique chemical and physical properties, such as their large surface area and small size effect, which have greatly promoted developments in life science and technology. Additionally, PCR technology assisted by NPs (NanoPCR) such as gold NPs (Au NPs), quantum dots (QDs), and carbon nanotubes (CNTs), etc., have been developed to significantly improve the specificity, efficiency, and sensitivity of PCR and to accelerate the PCR reaction process. This review discusses the roles of different types of NPs used to enhance PCR and summarizes their possible mechanisms.
Silymarin Protects against Acute Liver Injury Induced by Acetaminophen by Downregulating the Expression and Activity of the CYP2E1 Enzyme
Authors: Yang Weipei , Liang Zhongxu , Wen Chengming , Jiang Xuehua , Wang Ling
Published: December 2022

Previous studies have shown that silymarin protects against various types of drug-induced liver injury, but whether the protective mechanism of silymarin against acetaminophen-induced liver injury is related to the CYP2E1 enzyme remains unclear. In this study, we investigated the effect of silymarin on the activity and expression of CYP2E1 in vitro and in vivo. The results of in vitro studies showed that silymarin not only inhibited the activity of CYP2E1 in human and rat liver microsomes but also reduced the expression of CYP2E1 in HepG2 cells. In vivo studies showed that silymarin pretreatment significantly reduced the conversion of chlorzoxazone to its metabolite 6-OH-CLX and significantly increased the t1/2, area under the curve (AUC) and mean residence time (MRT) of chlorzoxazone. In addition, silymarin pretreatment significantly inhibited the upregulation of Cyp2e1 expression, reduced the production of 3-cysteinylacetaminophen trifluoroacetic acid salt (APAP-CYS), and restored the liver glutathione level. The results of our study show that silymarin plays an important protective role in the early stage of acetaminophen-induced acute liver injury by reducing the activity and expression of CYP2E1, reducing the generation of toxic metabolites, and alleviating liver injury.
Therapeutic Importance of Kaempferol in the Treatment of Cancer through the Modulation of Cell Signalling Pathways
Authors: Qattan Malak Yahia , Khan Mohammad Idreesh , Alharbi Shudayyed Hasham , Verma Amit Kumar , Al-Saeed Fatimah A. , Abduallah Alduwish Manal , Al Areefy Azza A.
Published: December 2022

Plant-derived flavonoids are considered natural nontoxic chemo-preventers and have been widely studied for cancer treatment in recent decades. Mostly all flavonoid compounds show significant anti-inflammatory, anticancer and antioxidant properties. Kaempferol (Kmp) is a well-studied compound and exhibits remarkable anticancer and antioxidant potential. Kmp can regulate various cancer-related processes and activities such as cell cycle, oxidative stress, apoptosis, proliferation, metastasis, and angiogenesis. The anti-cancer properties of Kmp primarily occur via modulation of apoptosis, MAPK/ERK1/2, P13K/Akt/mTOR, vascular endothelial growth factor (VEGF) signalling pathways. The anti-cancer property of Kmp has been recognized in several in-vivo and in-vitro studies which also includes numerous cell lines and animal models. This flavonoid possesses toxic activities against only cancer cells and have restricted toxicity on healthy cells. In this review, we present extensive research investigations about the therapeutic potential of Kmp in the management of different types of cancers. The anti-cancer properties of Kmp are discussed by concentration on its capability to target molecular-signalling pathway such as VEGF, STAT, p53, NF-κB and PI3K-AKT signalling pathways. The anti-cancer property of Kmf has gained a lot of attention, but the accurate action mechanism remains unclear. However, this natural compound has a great pharmacological capability and is now considered to be an alternative cancer treatment.
Combined Experimental and Theoretical Investigation into the Photophysical Properties of Halogenated Coelenteramide Analogs
Authors: Afonso Ana Carolina P. , González-Berdullas Patricia , Esteves da Silva Joaquim C. G. , Pinto da Silva Luís
Published: December 2022

Marine Coelenterazine is one of the most well-known chemi-/bioluminescent systems, and in which reaction the chemi-/bioluminophore (Coelenteramide) is generated and chemiexcited to singlet excited states (leading to light emission). Recent studies have shown that the bromination of compounds associated with the marine Coelenterazine system can provide them with new properties, such as anticancer activity and enhanced emission. Given this, our objective is to characterize the photophysical properties of a previously reported brominated Coelenteramide analog, by employing a combined experimental and theoretical approach. To better analyze the potential halogen effect, we have also synthesized and characterized, for the first time, two new fluorinated and chlorinated Coelenteramide analogs. These compounds show similar emission spectra in aqueous solution, but with different fluorescence quantum yields, in a trend that can be correlated with the heavy-atom effect (F > Cl > Br). A blue shift in emission in other solvents is also verified with the F–Cl–Br trend. More relevantly, the fluorescence quantum yield of the brominated analog is particularly sensitive to changes in solvent, which indicates that this compound has potential use as a microenvironment fluorescence probe. Theoretical calculations indicate that the observed excited state transitions result from local excitations involving the pyrazine ring. The obtained information should be useful for the further exploration of halogenated Coelenteramides and their luminescent properties.
Phytochemical Profiling, Isolation, and Pharmacological Applications of Bioactive Compounds from Insects of the Family Blattidae Together with Related Drug Development
Authors: Liang Siwei , Zhang Yifan , Li Jing , Yao Shun
Published: December 2022

In traditional Chinese medicine (TCM), insects from the family Blattidae have a long history of application, and their related active compounds have excellent pharmacological properties, making them a prominent concern with significant potential for medicinal and healthcare purposes. However, the medicinal potential of the family Blattidae has not been fully exploited, and many problems must be resolved urgently. Therefore, a comprehensive review of its chemical composition, pharmacological activities, current research status, and existing problems is necessary. In order to make the review clearer and more systematic, all the contents were independently elaborated and summarized in a certain sequence. Each part started with introducing the current situation or a framework and then was illustrated with concrete examples. Several pertinent conclusions and outlooks were provided after discussing relevant key issues that emerged in each section. This review focuses on analyzing the current studies and utilization of medicinal insects in the family Blattidae, which is expected to provide meaningful and valuable relevant information for researchers, thereby promoting further exploration and development of lead compounds or bioactive fractions for new drugs from the insects.
Antifungal Effect and Inhibition of the Virulence Mechanism of D-Limonene against Candida parapsilosis
Authors: Leite-Andrade Melyna Chaves , de Araújo Neto Luiz Nascimento , Buonafina-Paz Maria Daniela Silva , de Assis Graciano dos Santos Franz , da Silva Alves Adryelle Idalina , de Castro Maria Carolina Accioly Brelaz , Mori Edna , de Lacerda Bruna Caroline Gonçalves Vasconcelos , Araújo Isaac Moura , Coutinho Henrique Douglas Melo , Kowalska Grażyna , Kowalski Radosław , Baj Tomasz , Neves Rejane Pereira
Published: December 2022

Yeasts from the Candida parapsilosis complex are clinically relevant due to their high virulence and pathogenicity potential, such as adherence to epithelial cells and emission of filamentous structures, as well as their low susceptibility to antifungals. D-limonene, a natural compound, emerges as a promising alternative with previously described antibacterial, antiparasitic, and antifungal activity; however, its mechanisms of action and antivirulence activity against C. parapsilosis complex species have not been elucidated. Therefore, in the present study, we aimed to evaluate the antifungal and antivirulence action, as well as the mechanism of action of D-limonene against isolates from this complex. D-limonene exhibited relevant antifungal activity against C. parapsilosis complex yeasts, as well as excellent antivirulence activity by inhibiting yeast morphogenesis and adherence to the human epithelium. Furthermore, the apoptotic mechanism induced by this compound, which is not induced by oxidative stress, represents an important target for the development of new antifungal drugs.
The Circadian Syndrome Is a Significant and Stronger Predictor for Cardiovascular Disease than the Metabolic Syndrome—The NHANES Survey during 2005–2016
Authors: Shi Zumin , Tuomilehto Jaakko , Kronfeld-Schor Noga , Alberti George , Stern Naftali , El-Osta Assam , Chai Zhonglin , Bilu Carmel , Einat Haim , Zimmet Paul
Published: December 2022

The study aimed to compare the predictive value of the Circadian Syndrome (CircS) and Metabolic Syndrome (MetS) for cardiovascular disease (CVD). We used data of 12,156 adults aged ≥20 years who attended National Health and Nutrition Examination Survey (NHANES) 2005–2016. Mortality was obtained from the registry updated to 2019. The CircS was defined based on components of the MetS, in addition to short sleep and depression. Both the MetS and CircS were directly associated with self-reported history of CVD. The odds ratios for prevalent CVD associated with the CircS and MetS, respectively, were 2.92 (95% confidence interval (CI) 2.21–3.86) and 3.20 (2.38–4.30) in men, and 3.27 (2.34–4.59) and 3.04 (2.15–4.30) in women. The CircS had a better predictive power for prevalent CVD than that of MetS, as indicated by the higher positive predictive value (PPV); in men, the PPV for prevalent CVD with CircS was 23.1% and with MetS 20.9%, and in women these were 17.9% vs. 16.4%, respectively. However, the PPV of the CircS and MetS did not differ for the CVD mortality prediction. Women with CircS alone had a higher risk for both prevalent CVD and CVD mortality than those with MetS alone. In conclusion, the CircS is a significant and stronger predictor for CVD than the MetS in US adults.