bluuebunny/crossref_metadata_2025 huggingface dataset:
Paradise Regained? Localised and Limited Nature Connexions in the UK's Covid-19 Lockdown
Authors: Dobson Julian , Gore Tony , Graham Kim , Swade Kate
Published: December 2021

Research has suggested that connexions between humans and the natural world lead to increased well-being and generate pro-environmental attitudes, which in turn benefit nature. This article asks whether users of outdoor public spaces in the UK during the Covid-19 pandemic in 2020 experienced greater connectedness with nature, consistent with the five “pathways to nature connectedness” identified in previous research. Semi-structured interviews were conducted with a purposive sample of 42 individuals on their use of green and public spaces during the UK's lockdown, while a further 29 participants responded to an online survey. While the research revealed the importance of nature connectedness, only three of the five pathways were well-evidenced, and these connexions were frequently mediated by social activities. The article advances the study of nature connectedness by identifying challenges in applying the pathways framework and suggesting areas for further research to understand how the pathways operate in real-world conditions.
Casting the Net Widely for Change in Animal Welfare: The Plight of Birds in Zoos, Ex Situ Conservation, and Conservation Fieldwork
Authors: Kaplan Gisela
Published: December 2021

This paper discusses paradoxes in our relationship to and treatment of birds in captive and conservation contexts. The paper identifies modern and new challenges that arise from declining bird numbers worldwide. Such challenges have partly changed zoos into providers of insurance populations specifically for species at risk of extinction. They have also accelerated fieldwork projects, but by using advanced technological tools and in increasing numbers, contradictorily, they may cause serious harm to the very birds studied for conservation purposes. In practice, very few avian species have any notable protection or guarantee of good treatment. The paper first deals with shortcomings of identifying problematic avian behavior in captive birds. It then brings together specific cases of field studies and captive breeding for conservation in which major welfare deficits are identified. Indeed, the paper argues that avian welfare is now an urgent task. This is not just because of declining bird numbers but because of investment in new technologies in field studies that may have introduced additional stressors and put at risk bird survival. While the paper documents a substantial number of peer-reviewed papers criticizing practices counter to modern welfare standards, they have by and large not led to changes in some practices. Some solutions are suggested that could be readily implemented and, to my knowledge, have never been considered under a welfare model before.
The PACAP/PAC1 Receptor System and Feeding
Authors: Sureshkumar Keerthana , Saenz Andrea , Ahmad Syed M. , Lutfy Kabirullah
Published: December 2021

Pituitary adenylyl cyclase activating polypeptide (PACAP) belongs to the vasoactive intestinal polypeptide (VIP)/secretin/glucagon superfamily. PACAP is present in two forms (PACAP-38 and PACAP-27) and binds to three guanine-regulatory (G) protein-coupled receptors (PAC1, VPAC1, and VPAC2). PACAP is expressed in the central and peripheral nervous systems, with high PACAP levels found in the hypothalamus, a brain region involved in feeding and energy homeostasis. PAC1 receptors are high-affinity and PACAP-selective receptors, while VPAC1 and VPAC2 receptors show a comparable affinity to PACAP and VIP. PACAP and its receptors are expressed in the central and peripheral nervous systems with moderate to high expression in the hypothalamus, amygdala, and other limbic structures. Consistent with their expression, PACAP is involved in several physiological responses and pathological states. A growing body of literature suggests that PACAP regulates food intake in laboratory animals. However, there is no comprehensive review of the literature on this topic. Thus, the purpose of this article is to review the literature regarding the role of PACAP and its receptors in food intake regulation and to synthesize how PACAP exerts its anorexic effects in different brain regions. To achieve this goal, we searched PubMed and reviewed 68 articles regarding the regulatory action of PACAP on food intake. Here, we present the literature regarding the effect of exogenous PACAP on feeding and the role of endogenous PACAP in this process. We also provide evidence regarding the effect of PACAP on the homeostatic and hedonic aspects of food intake, the neuroanatomical sites where PACAP exerts its regulatory action, which PACAP receptors may be involved, and the role of various signaling pathways and neurotransmitters in hypophagic effects of PACAP.
DNA Methylation in INA, NHLH2, and THBS4 Is Associated with Metastatic Disease in Renal Cell Carcinoma
Authors: Katzendorn Olga , Peters Inga , Dubrowinskaja Natalia , Moog Joana M. , Reese Christel , Tezval Hossein , Faraj Tabrizi Pouriya , Hennenlotter Jörg , Lafos Marcel , Kuczyk Markus A. , Serth Jürgen
Published: December 2021

The detection of DNA methylation in primary tumor tissues could be relevant for early stratification of aggressive renal cell carcinomas (RCCs) as a basis for future personalized adjuvant therapy. Methylated TCGA KIRC based candidate CpG loci in INA, NHLH2, and THBS4 that are possibly associated with RCC metastasis were evaluated by pyrosequencing in 154 paired normal adjacent and primary tumor tissues, as well as in 202 metastatic tissues. Statistical analysis was carried out by bivariate logistic regression for group comparisons, log rank survival analysis, and unsupervised and supervised analysis for the classification of tumors. Increased methylation of INA, NHLH2, and THBS4 loci were significantly associated with distant metastasis in primary tumors (p < 0.05), tissue-specific hypermethylation in metastatic (p = 7.88 × 10−8, 5.57 × 10−10, 2.06 × 10−7) and tumor tissues (p = 3.72 × 10−24, 3.17 × 10−13, 1.58 × 10−19), and shortened progression free survival in patients (p = 0.03). Combined use of CpG site-specific methylation permits the discrimination of tissues with metastatic disease and reveals a significant contribution of CpG sites in all genes to the statistical classification model. Thus, metastasis in RCC is significantly associated with methylation alterations in INA, NHLH2, and THBS4 loci, providing independent information for the potential early detection of aggressive renal cancers as a rationale for stratifying patients to adjuvant therapies.
The Effect of Direct and Indirect EZH2 Inhibition in Rhabdomyosarcoma Cell Lines
Authors: Schmidt Andreas , Behrendt Lucas , Eybe Jana , Warmann Steven W. , Schleicher Sabine , Fuchs Joerg , Schmid Evi
Published: December 2021

Enhancer of Zeste homolog 2 (EZH2) is involved in epigenetic regulation of gene transcription by catalyzing trimethylation of histone 3 at lysine 27. In rhabdomyosarcoma (RMS), increased EZH2 protein levels are associated with poor prognosis and increased metastatic potential, suggesting EZH2 as a therapeutic target. The inhibition of EZH2 can be achieved by direct inhibition which targets only the enzyme activity or by indirect inhibition which also affects activities of other methyltransferases and reduces EZH2 protein abundance. We assessed the direct inhibition of EZH2 by EPZ005687 and the indirect inhibition by 3-deazaneplanocin (DZNep) and adenosine dialdehyde (AdOx) in the embryonal RD and the alveolar RH30 RMS cell line. EPZ005687 was more effective in reducing the cell viability and colony formation, in promoting apoptosis induction, and in arresting cells in the G1 phase of the cell cycle than the indirect inhibitors. DZNep was more effective in decreasing spheroid viability and size in both cell lines than EPZ005687 and AdOx. Both types of inhibitors reduced cell migration of RH30 cells but not of RD cells. The results show that direct and indirect inhibition of EZH2 affect cellular functions differently. The alveolar cell line RH30 is more sensitive to epigenetic intervention than the embryonal cell line RD.
Research on Anal Squamous Cell Carcinoma
Authors: Jethwa Krishan R. , Hallemeier Christopher L.
Published: December 2021

Anal canal and peri-anal squamous cell carcinomas (ASCCs) are relatively rare cancers that affect approximately 8000 patients per year in the United States [...]
Bcr-TMP, a Novel Nanomolar-Active Compound That Exhibits Both MYB- and Microtubule-Inhibitory Activity
Authors: Yusenko Maria V. , Biyanee Abhiruchi , Frank Daria , Köhler Leonhard H. F. , Andersson Mattias K. , Khandanpour Cyrus , Schobert Rainer , Stenman Göran , Biersack Bernhard , Klempnauer Karl-Heinz
Published: December 2021

Studies of the role of MYB in human malignancies have highlighted MYB as a potential drug target for acute myeloid leukemia (AML) and adenoid cystic carcinoma (ACC). Here, we present the initial characterization of 2-amino-4-(3,4,5-trimethoxyphenyl)-4H-naphtho[1,2-b]pyran-3-carbonitrile (Bcr-TMP), a nanomolar-active MYB-inhibitory compound identified in a screen for novel MYB inhibitors. Bcr-TMP affects MYB function in a dual manner by inducing its degradation and suppressing its transactivation potential by disrupting its cooperation with co-activator p300. Bcr-TMP also interferes with the p300-dependent stimulation of C/EBPβ, a transcription factor co-operating with MYB in myeloid cells, indicating that Bcr-TMP is a p300-inhibitor. Bcr-TMP reduces the viability of AML cell lines at nanomolar concentrations and induces cell-death and expression of myeloid differentiation markers. It also down-regulates the expression of MYB target genes and exerts stronger anti-proliferative effects on MYB-addicted primary murine AML cells and patient-derived ACC cells than on their non-oncogenic counterparts. Surprisingly, we observed that Bcr-TMP also has microtubule-disrupting activity, pointing to a possible link between MYB-activity and microtubule stability. Overall, Bcr-TMP is a highly potent multifunctional MYB-inhibitory agent that warrants further investigation of its therapeutic potential and mechanism(s) of action.
Immune Checkpoint Inhibitor Treatment and Ophthalmologist Consultations in Patients with Malignant Melanoma or Lung Cancer—A Nationwide Cohort Study
Authors: D’Souza Maria , Bagger Mette , Alberti Mark , Malmborg Morten , Schou Morten , Torp-Pedersen Christian , Gislason Gunnar , Svane Inge Marie , Kiilgaard Jens Folke
Published: December 2021

Purpose: To estimate the frequency of first-time ocular events in patients treated with immune checkpoint inhibitors (ICI). Methods: Patients with cancer in 2011–2018 in Denmark were included and followed. The outcomes were first-time ophthalmologist consultation and ocular inflammation. One-year absolute risks of outcomes and hazard ratios were estimated. Results: 112,289 patients with cancer were included, and 2195 were treated with ICI. One year after the first ICI treatment, 6% of the patients with cancer, 5% and 8% of the lung cancer (LC) and malignant cutaneous melanoma (MM) patients, respectively, had a first-time ophthalmologist consultation. The risk of ocular inflammation was 1% (95% confidence interval (CI) 0.4–1.2). Among patients with MM, ICI was associated with ocular inflammation in women (HR 12.6 (95% CI 5.83–27.31) and men (4.87 (95% CI 1.79–13.29)). Comparing patients with and without ICI treatment, the risk of first-time ophthalmologist consultation was increased in patients with LC (HR 1.74 (95% CI 1.29–2.34) and MM (HR 3.21 (95% CI 2.31–4.44). Conclusions: The one-year risks of first-time ophthalmologist consultation and ocular inflammation were 6% and 1%, respectively, in patients treated with ICI. In patients with LC and MM, the risk was increased in patients with ICI compared with patients without ICI.
Development and Evaluation of the Canteen Connect Online Health Community: Using a Participatory Design Approach in Meeting the Needs of Young People Impacted by Cancer
Authors: Cohen Jennifer , Patterson Pandora , Noke Melissa , Clarke Kristina , Husson Olga
Published: December 2021

Adolescent and young adults (AYAs) impacted by their own or familial cancer require information and peer support throughout the cancer journey to ameliorate feelings of isolation. Online Health Communities (OHC) provide social networks, support, and health-related content to people united by a shared health experience. Using a participatory design (PD) process, Canteen developed Canteen Connect (CC), an OHC for AYAs impacted by cancer. This manuscript outlines the process used to develop CC: (1) A mixed-methods implementation evaluation of Version I of CC (CCv.1); (2) Qualitative workshops utilizing strengths-based approaches of PD and appreciative inquiry to inform the development of CC Version 2 (CCv.2); quantitative implementation evaluation to assess the appropriateness, acceptability, and effectiveness of CCv.2. Through several iterations designed and tested in collaboration with AYAs, CCv.2 had improvements in the user experience, such as the ability to send a private message to other users and the site becoming mobile responsive. Results from the evaluation showed CCv.2 was appropriate for connecting with other AYAs. Most AYAs reported satisfaction with CCv.2 and a positive impact on their feelings of sadness, worry, and/or anxiety. CCv.2 fills an important service provision gap in providing an appropriate and acceptable OHC for AYAs impacted by cancer, with initial promising psychological outcomes.
Immune Checkpoint Inhibitors in Mismatch Repair Proficient/Microsatellite Stable Metastatic Colorectal Cancer Patients: Insights from the AtezoTRIBE and MAYA Trials
Authors: Germani Marco Maria , Moretto Roberto
Published: December 2021

In metastatic colorectal cancer (mCRC), remarkable advances have been achieved with immune checkpoint inhibitors (ICIs) targeting PD-1/PD-L1 and CTLA-4, only in a small subset of tumours (4–5%), harbouring a deficient mismatch repair system (dMMR)/microsatellite instability–high (MSI-H) or mutations in the catalytic subunit of polymerase epsilon (POLE). Within this framework, several combination strategies have been investigated to sensitize proficient mismatch repair (pMMR)/microsatellite stable (MSS) mCRC to ICIs, with disappointing results so far. However, at the last ESMO meeting, two phase II trials AtezoTRIBE and MAYA provided promising results in this field. In the comparative AtezoTRIBE trial, the addition of atezolizumab to FOLFOXIRI (5-fluoruracil, oxaliplatin and irinotecan) and bevacizumab led to a significant advantage in terms of progression free survival (PFS) in a population of untreated mCRC patients, not selected according to MMR/MSI status. In the single-arm MAYA trial, immune priming with temozolomide in pMMR/MSS chemo-resistant mCRC patients with silencing of O6-methylguanine-DNA methyltransferase (MGMT) allowed reporting signals of sensitivity to the subsequent therapy with nivolumab and a low dose of ipilimumab in some patients. Here, we discuss the rationale, results, criticisms and research perspectives opened by these two studies.
PCP4/PEP19 and HER2 Are Novel Prognostic Markers in Mucoepidermoid Carcinoma of the Salivary Gland
Authors: Yoshimura Takuya , Higashi Shotaro , Yamada Sohsuke , Noguchi Hirotsugu , Nomoto Mitsuharu , Suzuki Hajime , Ishida Takayuki , Takayama Hirotaka , Hirano Yuka , Yamashita Masaru , Tanimoto Akihide , Nakamura Norifumi
Published: December 2021

Mucoepidermoid carcinoma (MEC) is one of the most common malignant salivary gland carcinomas, but no effective treatment strategy has been established other than surgical resection. Purkinje cell protein (PCP) 4/peptide (PEP) 19 is a calmodulin-binding antiapoptotic peptide that is expressed and inhibits apoptosis in human breast cancer cells. Human epidermal growth factor receptor 2 (HER2) is an epidermal growth factor that has been implicated in the pathogenesis of many carcinomas, particularly breast and gastric carcinomas. In the present study, we performed immunohistochemical analyses of samples from 73 patients who underwent surgical resection for MEC of the salivary gland using antibodies against PCP4/PEP19 and HER2. PCP4/PEP19 expression was related to better prognosis, while HER2 expression was associated with worse prognosis. Patients that were PCP4/PEP19-positive and HER2-negative showed similar outcomes to PCP4/PEP19 and HER2 alone. Therefore, PCP4/PEP19 and HER2 are predicted to play important roles in the pathogenesis and progression of MEC.
Allogeneic Stem Cell Transplantation in Multiple Myeloma
Authors: Greil Christine , Engelhardt Monika , Finke Jürgen , Wäsch Ralph
Published: December 2021

The development of new inhibitory and immunological agents and combination therapies significantly improved response rates and survival of patients diagnosed with multiple myeloma (MM) in the last decade, but the disease is still considered to be incurable by current standards and the prognosis is dismal especially in high-risk groups and in relapsed and/or refractory patients. Allogeneic hematopoietic stem cell transplantation (allo-SCT) may enable long-term survival and even cure for individual patients via an immune-mediated graft-versus-myeloma (GvM) effect, but remains controversial due to relevant transplant-related risks, particularly immunosuppression and graft-versus-host disease, and a substantial non-relapse mortality. The decreased risk of disease progression may outweigh this treatment-related toxicity for young, fit patients in high-risk constellations with otherwise often poor long-term prognosis. Here, allo-SCT should be considered within clinical trials in first-line as part of a tandem approach to separate myeloablation achieved by high-dose chemotherapy with autologous SCT, and following allo-SCT with a reduced-intensity conditioning to minimize treatment-related organ toxicities but allow GvM effect. Our review aims to better define the role of allo-SCT in myeloma treatment particularly in the context of new immunomodulatory approaches.
Survival Benefit of Resection Surgery for Pancreatic Ductal Adenocarcinoma with Liver Metastases: A Propensity Score-Matched SEER Database Analysis
Authors: Pausch Thomas M. , Liu Xinchun , Cui Jiaqu , Wei Jishu , Miao Yi , Heger Ulrike , Probst Pascal , Heap Stephen , Hackert Thilo
Published: December 2021

Guidelines do not recommend resection surgery for oligometastatic pancreatic ductal adenocarcinoma (PDAC). However, reports in small samples of selected patients suggest that surgery extends survival. Thus, this study aims to gather evidence for the benefits of cancer-directed surgery (CDS) by analyzing a national cohort and identifying prognostic factors that aid the selection of candidates for CDS or recruitment into experimental trials. Data for patients with PDAC and hepatic metastasis were extracted from the population-based Surveillance, Epidemiology, and End Results database (SEER). The bias between CDS and non-CDS groups was minimized with Propensity Score Matching (PSM), and the prognostic role of CDS was investigated by comparing Kaplan-Meier estimators and Cox proportional hazard models. A total of 12,018 patients were extracted from the database, including 259 patients who underwent CDS that were 1:1 propensity score-matched with patients who did not receive CDS. CDS appeared to significantly prolong median overall survival from 5 to 10 months. Multivariate analysis revealed chemotherapy as a protective prognostic, whilst survival was impaired by old age and tumors that were poorly differentiated (Grades III–IV). These factors can be used to select patients likely to benefit from CDS treatment, which may facilitate recruitment into randomized controlled trials.
Adenoma to Colorectal Cancer Estimated Transition Rates Stratified by BMI Categories—A Cross-Sectional Analysis of Asymptomatic Individuals from Screening Colonoscopy Program
Authors: Spychalski Piotr , Kobiela Jarek , Wieszczy Paulina , Bugajski Marek , Reguła Jaroslaw , Kaminski Michał F.
Published: December 2021

Most colorectal cancers (CRC) assumedly develop from precursor lesions, i.e., colorectal adenomas (adenoma-carcinoma sequence). Epidemiological and clinical data supporting this hypothesis are limited. Therefore, the aim of the present study is to estimate relative dynamics of colorectal adenoma-carcinoma sequence for groups of screenees stratified by BMI (body mass index) based on prevalence data from Polish Colonoscopy Screening Program (PCSP). We performed a cross-sectional analysis of database records of individuals who entered the national opportunistic colonoscopy screening program for CRC in Poland. We calculated prevalence of adenomas and CRCs adjusted for sex, 5-year age group, family history of CRC, smoking, diabetes and use of aspirin, hormonal therapy and proton-pump inhibitors use. Thereafter we calculated estimated transition rate (eTR) with confidence intervals (CIs) defined as adjusted prevalence of more advanced lesion divided by adjusted prevalence of less advanced lesion. All analyzes were stratified according to the BMI categories: normal (BMI 18.0 to <25.0), overweight (BMI 25.0 to <30.0) and obese (BMI ≥ 30.0). Results are reported in the same respective order. After exclusions we performed analyses on 147,385 individuals. We found that prevalence of non-advanced adenomas is increasing with BMI category (12.19%, 13.81%, 14.70%, respectively; p < 0.001). Prevalence of advanced adenomas was increasing with BMI category (5.20%, 5.77%, 6.61%, respectively; p < 0.001). Early CRCs prevalence was the highest for obese individuals (0.55%) and the lowest for overweight individuals (0.44%) with borderline significance (p = 0.055). For advanced CRC we found that prevalence seems to be inversely related to BMI category, however no statistically significant differences were observed (0.35%, 0.31%, 0.28%; p = 0.274). eTR for non-advanced adenoma to advanced adenoma is higher for obese individuals than for overweight individuals with bordering CIs (42.65% vs. 41.81% vs. 44.95%) eTR for advanced adenoma to early CRC is highest for normal individuals, however CIs are overlapping with remaining BMI categories (9.02% vs. 7.67% vs. 8.39%). eTR for early CRC to advanced CRC is lower for obese individuals in comparison to both normal and overweight individuals with marginally overlapping CIs (73.73% vs. 69.90% vs. 50.54%). Obese individuals are more likely to develop adenomas, advanced adenomas and early CRC but less likely to progress to advanced CRC. Therefore, this study provides new evidence that obesity paradox exists for colorectal cancer.
The Impact of Vulvar Cancer on Psychosocial and Sexual Functioning: A Literature Review
Authors: Malandrone Francesca , Bevilacqua Federica , Merola Mariagrazia , Gallio Niccolò , Ostacoli Luca , Carletto Sara , Benedetto Chiara
Published: December 2021

Women who are diagnosed and treated for vulvar cancer are at higher risk of psychological distress, sexual dysfunction and dissatisfaction with partner relationships. The aim of this article is to provide a review of the psychological, relational and sexual issues experienced by women with vulvar cancer in order to highlight the importance of this issue and improve the quality of care offered to these patients. A review of the literature was performed using PubMed, CINAHL, PsycINFO, and the Cochrane Library. The results are presented as a narrative synthesis and highlight the massive impact of vulvar cancer: depressive and anxiety symptoms were more frequent in these women, and vulvar cancer may have a negative effect on sexuality from a physical, psychological and behavioural point of view. Factors that may negatively affect these women’s lives are shame, insecurity or difficulties in self-care and daily activities. This review highlights the psychosocial and psychosexual issues faced by women diagnosed and treated for vulvar cancer, although more studies are needed to better investigate this field of interest and to identify strategies to relieve their psychological distress. Care providers should implement an integrated care model to help women with vulvar cancer recognise and address their unmet needs.
Fecal microRNAs, Fecal microRNA Panels, or Combinations of Fecal microRNAs with Fecal Hemoglobin for Early Detection of Colorectal Cancer and Its Precursors: A Systematic Review
Authors: Zhao Zitong , Zhu Anna , Bhardwaj Megha , Schrotz-King Petra , Brenner Hermann
Published: December 2021

Colorectal cancer (CRC) is the third most common cancer and the second leading cause of cancer mortality globally. Fecal miRNAs have been suggested to be promising biomarkers for CRC early detection. We aimed to conduct a systematic literature review on the diagnostic performance of fecal miRNA markers for CRC and its precursors. PubMed and Web of Science were searched to retrieve relevant articles published up to 7 December 2021. Information on study design, characteristics of study population, pre-analytics (sample collection, processing, and storage), fecal miRNA extraction and quantification technologies, and diagnostic performance (including sensitivity, specificity, and area under the curve (AUC)) were summarized. Twenty studies reporting on 31 individual miRNAs and 16 miRNA panels (with 2–9 markers) for CRC diagnosis were identified. Substantial heterogeneity existed regarding stool sample collection, processing, storage, and miRNA extraction and normalization. For two individual miRNAs and one miRNA panel, values ≥ 80% were reported for both sensitivity and specificity; however, none of these results were either internally or externally validated. In a study among fecal immunochemical test-positive cases recruited from a true screening setting, better diagnostic performance was identified and internally validated for a combination panel including two miRNAs, fecal hemoglobin level, and patient age and sex, compared with fecal hemoglobin concentration alone. Fecal miRNAs or miRNA panels, possibly in combination with fecal hemoglobin test, may be promising candidates for noninvasive CRC early detection. However, large prospective and well-designed studies in CRC screening cohorts are required to validate promising miRNAs or miRNA panels.
Concentration-Dependent Association of Flavylium Chloride with Differential Hydroxy Moieties in Ethanol
Authors: Pagan Anthony , Lee Jong I. , Kang Jeonghee
Published: December 2021

Flavylium ions (6a–6e) were synthesized using Aldol condensation to compare the spectroscopic properties caused by the different numbers and locations of hydroxy groups on the flavylium cations (AH+). Without the addition of acid, increasing the concentration of flavylium ions to 10 mM in ethanol led to the following observation. The flavylium ions with the least number of OH groups (6a and 6b) showed a change in peak at higher concentrations, whereas 6c and 6d did not show the same degree of change in their 1H-NMR signals. This suggests an equilibrium that shifts the isomers B, CE, and Cz more towards the flavylium ion with more OH groups even at low concentrations. One possibility for the cause of this shift is that the flavylium ions become more stable through aggregation. In addition to the NMR results, the UV measurements confirmed that isomers with fewer OH groups showed a more dramatic shift towards the flavylium ion at higher concentrations. Using modeling data at DFT//B3LYP/6311**G(d) level, the self-association was investigated to show that the hydrogen bonding of OH groups is the main player but cannot stabilize entirely without the presence of the chloride ion in the complex.
Improving Scientific Knowledge of Mallorca Channel Seamounts (Western Mediterranean) within the Framework of Natura 2000 Network
Authors: Massutí Enric , Sánchez-Guillamón Olga , Farriols Maria Teresa , Palomino Desirée , Frank Aida , Bárcenas Patricia , Rincón Beatriz , Martínez-Carreño Natalia , Keller Stefanie , López-Rodríguez Carmina , Díaz Julio A. , López-González Nieves , Marco-Herrero Elena , Fernandez-Arcaya Ulla , Valls Maria , Ramírez-Amaro Sergio , Ferragut Francesca , Joher Sergi , Ordinas Francisco , Vázquez Juan-Tomás
Published: December 2021

The scientific exploration of Mallorca Channel seamounts (western Mediterranean) is improving the knowledge of the Ses Olives (SO), Ausias March (AM), and Emile Baudot (EB) seamounts for their inclusion in the Natura 2000 network. The aims are to map and characterize benthic species and habitats by means of a geological and biological multidisciplinary approach: high-resolution acoustics, sediment and rock dredges, beam trawl, bottom trawl, and underwater imagery. Among the seamounts, 15 different morphological features were differentiated, highlighting the presence of 4000 pockmarks, which are seafloor rounded depressions indicators of focused fluid flow escapes, usually gas and/or water, from beneath the seabed sediments. So far, a total of 547 species or taxa have been inventoried, with sponges, fishes, mollusks, and crustaceans the most diverse groups including new taxa and new geographical records. Up to 29 categories of benthic habitats have been found, highlighting those included in the Habitats Directive: maërl beds on the summits of AM and EB, pockmarks around the seamounts and coral reefs in their rocky escarpments as well as fields of Isidella elongata on sedimentary bathyal bottoms. Trawling is the main demersal fishery developed around SO and AM, which are targeted to deep water crustaceans: Parapenaeus longirostris, Nephrops norvegicus, and Aristeus antennatus. This study provides scientific information for the proposal of the Mallorca Channel seamounts as a Site of Community Importance and for its final declaration as a Special Area of Conservation.
Evolving Network Analysis of S&P500 Components: COVID-19 Influence of Cross-Correlation Network Structure
Authors: Miśkiewicz Janusz , Bonarska-Kujawa Dorota
Published: December 2021

The economy is a system of complex interactions. The COVID-19 pandemic strongly influenced economies, particularly through introduced restrictions, which formed a completely new economic environment. The present work focuses on the changes induced by the COVID-19 epidemic on the correlation network structure. The analysis is performed on a representative set of USA companies—the S&P500 components. Four different network structures are constructed (strong, weak, typically, and significantly connected networks), and the rank entropy, cycle entropy, averaged clustering coefficient, and transitivity evolution are established and discussed. Based on the mentioned structural parameters, four different stages have been distinguished during the COVID-19-induced crisis. The proposed network properties and their applicability to a crisis-distinguishing problem are discussed. Moreover, the optimal time window problem is analysed.
On the Transformation Optimization for Stencil Computation
Authors: Su Huayou , Zhang Kaifang , Mei Songzhu
Published: December 2021

Stencil computation optimizations have been investigated quite a lot, and various approaches have been proposed. Loop transformation is a vital kind of optimization in modern production compilers and has proved successful employment within compilers. In this paper, we combine the two aspects to study the potential benefits some common transformation recipes may have for stencils. The recipes consist of loop unrolling, loop fusion, address precalculation, redundancy elimination, instruction reordering, load balance, and a forward and backward update algorithm named semi-stencil. Experimental evaluations of diverse stencil kernels, including 1D, 2D, and 3D computation patterns, on two typical ARM and Intel platforms, demonstrate the respective effects of the transformation recipes. An average speedup of 1.65× is obtained, and the best is 1.88× for the single transformation recipes we analyze. The compound recipes demonstrate a maximum speedup of 1.92×.
Reliability of Equilibrium Gasification Models for Selected Biomass Types and Compositions: An Overview
Authors: Moretti Linda , Arpino Fausto , Cortellessa Gino , Di Fraia Simona , Di Palma Maria , Vanoli Laura
Published: December 2021

In this paper, the authors present an overview of biomass gasification modeling approaches with the aim of evaluating their effectiveness as a modeling tool for the design and optimization of polygeneration plants based on biomass gasification. In fact, the necessity to build plant operating maps for efficiency optimization requires a significant number of simulations, and non-stoichiometry equilibrium models may allow fast computations thanks to their relative simplicity. The main objective consists of the assessment of thermodynamic equilibrium models performance as a function of biomass type and composition to better understand in which conditions of practical interest such models can be applied with acceptable reliability. To this aim, the authors developed two equilibrium models using both a commercial software (referred as Aspen model) and a simulation tool implemented in a non-commercial script (referred as analytical model). To assess their advantages and disadvantages, the two models were applied to the gasification simulation of different biomasses, employing experimental data available from the scientific literature. The obtained results highlighted strengths and limitations of using equilibrium models as a function of biomass type and composition. For example, they showed that the analytical model predicted syngas composition with better accuracy for biomass types characterized by a low ash content, whereas the Aspen model appeared to fairly predict the syngas composition at different conditions of ER; however, its accuracy might be reduced if the properties of the treated biomass changed.
Optimal Operation of Multiple Energy System Based on Multi-Objective Theory and Grey Theory
Authors: Hu Bo , Wang Nan , Yu Zaiming , Cao Yunqing , Yang Dongsheng , Sun Li
Published: December 2021

The manufacturing industry consumes electricity and natural gas to provide the power and heat required for manufacturing. Additionally, large amounts of electric energy and heat energy are used, and the electricity cost, amount of environmental pollution, and equipment maintenance cost are high. Thus, optimizing the management of equipment with new energy is important to satisfy the load demand from the system. This paper formulates the scheduling problem of these multiple energy systems as a multi-objective linear regression model (MLRM), and an energy management system is designed focusing on the economy and on greenhouse gas emissions. Furthermore, a variety of optimization objectives and constraints are proposed to make the energy management scheme more practical. Then, grey theory is combined with the common MLRM to accurately represent the uncertainty in the system and to make the model better reflect the actual situation. This paper takes load fluctuation, total grid operation cost, and environmental pollution value as reference standards to measure the effect of the gray optimization algorithm. Lastly, the model is applied to optimize the energy supply plan and its performance is demonstrated using numerical examples. The verification results meet the optimized operating conditions of the multi-energy microgrid system.
Assessment of Operational Performance for an Integrated ‘Power to Synthetic Natural Gas’ System
Authors: Jurczyk Michał , Węcel Daniel , Uchman Wojciech , Skorek-Osikowska Anna
Published: December 2021

This article presents a power to SNG (synthetic natural gas) system that converts hydrogen into SNG via a methanation process. In our analysis, detailed models for all the elements of the system are built. We assume a direct connection between a wind farm and a hydrogen generator. For the purposes of our calculations, we also assume that the hydrogen generator is powered by the renewable source over a nine-hour period per day (between 21:00 and 06:00), and this corresponds to the off-peak period in energy demand. In addition, a hydrogen tank was introduced to maximize the operating time of the methanation reactor. The cooperation between the main components of the system were simulated using Matlab software. The primary aim of this paper is to assess the influence of various parameters on the operation of the proposed system, and to optimize its yearly operation via a consideration of the most important constraints. The analyses also examine different nominal power values of renewables from 8 to 12 MW and hydrogen generators from 3 to 6 MW. Implementing the proposed configuration, taking into account the direct connection of the hydrogen generator and the methanation reactor, showed that it had a positive effect on the dynamics and the operating times of the individual subsystems within the tested configuration.
Energy Poverty among Tertiary Students in Aotearoa New Zealand
Authors: Clark Isobel , Chun Saera , O’Sullivan Kimberley , Pierse Nevil
Published: December 2021

Energy poverty in Aotearoa New Zealand is well-documented, and tertiary students have been identified as an at-risk group. However, there has been very little research on tertiary students’ experiences of energy poverty in New Zealand. This paper used a nationwide online survey to investigate the extent and impact of energy poverty among tertiary students. Furthermore, it aimed to identify disparities between different demographic groups, understand the effects of COVID-19 and evaluate the effectiveness of the support policies available to students. Responses from 522 students were analysed; 85% were under 30 years old, 72% were female, 14% identified as Māori, and 14% reported having long-term disabilities or health concerns. The findings of this study are concerning. Tertiary students in New Zealand are largely living in dwelling conditions that do not meet recommended health standards and exacerbate energy poverty. Energy poverty has adverse effects on their physical and mental health; however, available support is limited or inaccessible. Most significantly, the impact of energy poverty is disproportionally affecting students with long-term disabilities or health concerns as well as students identifying as Māori. Moreover, the impact of COVID-19 further strained students experiencing energy poverty and again, disproportionally affected more vulnerable students.
Traffic and Energy Consumption Modelling of Electric Vehicles: Parameter Updating from Floating and Probe Vehicle Data
Authors: Croce Antonello Ignazio , Musolino Giuseppe , Rindone Corrado , Vitetta Antonino
Published: December 2021

This paper focuses on the estimation of energy consumption of Electric Vehicles (EVs) by means of models derived from traffic flow theory and vehicle locomotion laws. In particular, it proposes a bi-level procedure with the aim to calibrate (or update) the whole parameters of traffic flow models and energy consumption laws by means of Floating Car Data (FCD) and probe vehicle data. The reported models may be part of a procedure for designing and planning transport and energy systems. This aim is to verify if, and in what amount, the existing parameters of the resistances/energy consumptions model calibrated in the literature for Internal Combustion Engines Vehicles (ICEVs) change for EVs, considering the above circular dependency between supply, demand, and supply–demand interaction. The final results concern updated parameters to be used for eco-driving and eco-routing applications for design and a planning transport system adopting a multidisciplinary approach. The focus of this manuscript is on the transport area. Experimental data concern vehicular data extracted from traffic (floating car data and probe vehicle data) and energy consumption data measured for equipped EVs performing trips inside a sub-regional area, located in the Città Metropolitana of Reggio Calabria (Italy). The results of the calibration process are encouraging, as they allow for updating parameters related to energy consumption and energy recovered in terms of EVs obtained from data observed in real conditions. The latter term is relevant in EVs, particularly on urban routes where drivers experience unstable traffic conditions.
Impact of Cooling with Thermal Barrier Coatings on Flow Passage in a Gas Turbine
Authors: Zhang Yuanzhe , Liu Pei , Li Zheng
Published: December 2021

Inlet temperature is vital to the thermal efficiency of gas turbines, which is becoming increasingly important in the context of structural changes in power supplies with more intermittent renewable power sources. Blade cooling is a key method for gas turbines to maintain high inlet temperatures whilst also meeting material temperature limits. However, the implementation of blade cooling within a gas turbine—for instance, thermal barrier coatings (TBCs)—might also change its heat transfer characteristics and lead to challenges in calculating its internal temperature and thermal efficiency. Existing studies have mainly focused on the materials and mechanisms of TBCs and the impact of TBCs on turbine blades. However, these analyses are insufficient for measuring the overall impact of TBCs on turbines. In this study, the impact of TBC thickness on the performance of gas turbines is analyzed. An improved mathematical model for turbine flow passage is proposed, considering the impact of cooling with TBCs. This model has the function of analyzing the impact of TBCs on turbine geometry. By changing the TBCs’ thickness from 0.0005 m to 0.0013 m, its effects on turbine flow passage are quantitatively analyzed using the proposed model. The variation rules of the cooling air ratio, turbine inlet mass flow rate, and turbine flow passage structure within the range of 0.0005 m to 0.0013 m of TBC thicknesses are given.
Policy Insights to Accelerate Cleaner Steam-Assisted Gravity Drainage Operations
Authors: Hannouf Marwa , Assefa Getachew , Gates Ian
Published: December 2021

The literature is replete with concerns on the environmental impact of steam-assisted gravity drainage (SAGD), but rigorous analysis of its improved environmental performance over the past 20 years remains unresolved, as well as the underlying technological reasons for this improvement. Here, we present an analysis of historical and future greenhouse gas (GHG) performance of SAGD operations in Alberta, Canada, considering for the first-time factors that affected technology deployment. Depending on the case, the results show a reduction of 1.4–24% of SAGD GHG intensity over the past 12 years. Improvements mainly arise from incremental changes adopted based on technical, environmental, socio-economic, and policy drivers. Considering these factors, we propose policy interventions to accelerate further reductions of GHG emissions. However, if similar behaviour from industry continues, anticipated GHG intensity reduction will range between 6.5–40% by 2030, leading to an intensity between 58 and 68 kgCO2e/bbl. It still remains unclear if in situ oil sands bitumen extraction will reach current conventional oil emission intensities. Thus, we suggest that the SAGD industry drastically accelerate its deployment of cleaner oil sands extraction technologies considering the policy insights proposed.
Economic Feasibility of Agricultural Biogas Production by Farms in Ukraine
Authors: Trypolska Galyna , Kyryziuk Sergii , Krupin Vitaliy , Wąs Adam , Podolets Roman
Published: December 2021

Renewable energy generation in Ukraine is developing slower than state strategies and expectations, with the installations for energy generation based on biogas currently being among the lowest in terms of installed capacity. Most of those involved in energy generation from agricultural biogas are large enterprises, while the small and medium-sized farms are far less involved. Thus the article aims to assess the economic feasibility of biogas production from agricultural waste by specific farm types and sizes, with a special focus on small and medium-sized farms. The research results present findings in two dimensions, first defining the economic feasibility of biogas installations in Ukraine based on investment costs and the rate of return at both the current and potential feed-in tariff, and second, analyzing the influence of state regulation and support on the economic feasibility of agricultural biogas production in Ukraine. The results emphasize that the construction of small generation capacities does not provide sufficient funds under the current feed-in tariff to meet the simple return period expected by the domestic financing institutions. Except for the general support programs for agricultural activities, there are no support funds specifically for biogas producers, while there is tight competition with wind and solar energy due to diversified feed-in tariffs.
Review on the Traditional and Integrated Passives: State-of-the-Art Design and Technologies
Authors: Khowja Muhammad Raza , Abebe Robert , Vakil Gaurang , Walker Adam , Patel Chintan , Gerada Chris , Bobba Phaneendra Babu , Cascella Giuseppe Leonardo
Published: December 2021

With the increased necessity of a high power density and efficient system in aerospace and marine industries, integrated motor drives provide an excellent solution in the modern era. Therefore, a close structural and functional integration of passive components has become a prerequisite task to make a compact overall system. This article reviews the existing motor drives system with integrated passive technologies. To start, the design aspect of the traditional and integrated filter inductors, using the area product approach, is discussed. Subsequently, layouts of traditional and integrated inductors are presented. The available capacitor technologies, suitable for integration, are also discussed with pros and cons of each capacitor type.
A Symbiotic Organism Search-Based Selective Harmonic Elimination in a Switched Capacitor Multilevel Inverter
Authors: Kumari Manita , Sarwar Adil , Tariq Mohd , Ahmad Shafiq , Shah Noor Mohamed Adamali , Rodrigues Eduardo M. G.
Published: December 2021

Multilevel inverters are increasingly being employed for industrial applications, such as speed control of motors and grid integration of distributed generation systems. The focus is on developing topologies that utilize fewer lower-rating switches and power sources while working efficiently and reliably. This work pertains to developing a three-phase multilevel inverter that employs switching capacitors and a single DC power supply that produces a nine-stage, three-phase voltage output. A recently proposed powerful meta-heuristic technique called symbiotic organism search (SOS) has been applied to identify the optimum switching angles for Selective Harmonic Elimination (SHE) from the output voltage waveform. A thorough converter analysis has also been done in the MATLAB/SIMULINK environment and is validated with the real-time hardware-in-the-loop (HIL) experiment results.
Absorption Chillers to Improve the Performance of Small-Scale Biomethane Liquefaction Plants
Authors: Ciambellotti Alessio , Pasini Gianluca , Baccioli Andrea , Ferrari Lorenzo , Barsali Stefano
Published: December 2021

Biomethane liquefaction may help decarbonization in heavy transportation and other hard-to-abate sectors. Small-scale liquefaction plants (<10 ton/day) are suitable for small biogas plants located near farms and other agricultural activities. “Internal refrigerant” refrigeration cycles (e.g., Kapitza cycle) are often proposed for small-scale natural gas liquefaction due to their simplicity. An optimized Kapitza-based cycle is modeled and simulated, and then several modifications were studied to evaluate their influence on the energetic and economic performances. Results showed a specific consumption ranging between 0.65 kWh/kg and 0.54 kWh/kg of bio-LNG with no significant improvements by increasing cycle complexity. Instead, a reduction of 17% was achieved with the implementation of absorption chillers, that effectively turn waste heat into useful cooling energy. An economic assessment was finally carried showing that the Levelized Cost of Liquefation is more affected by electricity cost than additional CapEx.