bluuebunny/crossref_metadata_2025 huggingface dataset:
Hoạt động sàng lọc, chẩn đoán và điều trị bệnh tăng huyết áp và đái tháo đường tại trạm y tế xã phường trên toàn Thành phố Hồ Chí Minh
Authors: Nhật Phùng Đức , Thuỷ Nguyễn Xuân , Phương Hoàng Thị Diễm , Dung Ngô Thị Thuỳ , Hưng Nguyễn Hữu , Ngọc Võ Hồng , Tâm Phan Thanh , Ưng Quách Kim , Nhung Phan Thị Mỹ , Anh Nguyễn Thị Duyên , Nam Nguyễn Thị Thu , Tuấn Nguyễn Thanh
Published: December 2021

Nghiên cứu được tiến hành nhằm mô tả kết quả triển khai và nhân rộng, và bài học kinh nghiệm trong hoạt động sàng lọc, chẩn đoán và điều trị bệnh tăng huyết áp (THA) và đái tháo đường (ĐTĐ) tại trạm y tế xã, phường (TYT) của Thành phố Hồ Chí Minh. Nghiên cứu phối hợp rà soát số liệu sẵn có của dự án và tiến hành 36 phỏng vấn sâu với đại diện Bộ Y tế và Tổ chức Y tế Thế giới, cán bộ ngành y tế các tuyến, cộng tác viên và khách hàng của chương trình. Từ năm 2016 - 2020, chương trình được nhân rộng từ 5 TYT của 1 quận sang 294 TYT tại 23 quận huyện trên toàn thành phố, đã sàng lọc gần 100.000 người, và thu hút 11.170 người bệnh THA và ĐTĐ điều trị tại TYT. Yếu tố thúc đẩy hoạt động và nhân rộng là: 1) can thiệp phù hợp với chỉ đạo và chính sách y tế quốc gia, 2) mô hình được tích hợp tốt vào hệ thống y tế công, 3) can thiệp phù hợp với năng lực kỹ thuật của TYT, 4) nhân viên y tế và các nhà quản lý tự tin với các biện pháp can thiệp, và 5) khách hàng hài lòng với dịch vụ nhận được. Nghiên cứu cũng chỉ ra khó khăn liên quan tới nhân lực, tài chính/ bảo hiểm, và hệ thống thông tin y tế. Nghiên cứu cho thấy mô hình chăm sóc THA và ĐTĐ tại TYT là khả thi và có thể nhân rộng một cách hiệu quả.
Chất lượng cuộc sống và một số yếu tố liên quan ở người bệnh ung thư điều trị tại Bệnh viện Ung bướu Thành phố Cần Thơ năm 2020
Authors: Quang Huỳnh Nguyễn Phương , Thuận Nguyễn Thị Hồng , Thảo Huỳnh Nguyễn Phương
Published: December 2021

Nghiên cứu mô tả cắt ngang trên 1050 bệnh nhân điều trị nội trú tại Bệnh viện Ung bướu thành phố Cần Thơ năm 2020 bằng bảng điểm đánh giá chất lượng cuộc sống (CLCS) cho bệnh nhân ung thư EORTC QLQ-C30. Kết quả nghiên cứu cho thấy điểm số chất lượng cuộc sống trung bình là 51,64 ± 25,14 điểm. Ghi nhận các yếu tố: Sống tại thành thị (p < 0,022), trình độ học vấn cao (p < 0,001), nghề nghiệp (p < 0,001), kinh tế gia đình (p < 0,001), có tham gia bảo hiểm y tế (p = 0,016), thu nhập hàng tháng cao (p < 0,001), bệnh ở giai đoạn bệnh muộn (p < 0,001), ung thư có di căn (p < 0,001), thời gian mắc bệnh (p = 0,003), phương pháp điều trị (p < 0,001), không có bệnh lý kèm theo (p < 0,001) và có sự chăm sóc hỗ trợ của gia đình (p < 0,001) tác động có ý nghĩa thống kê cải thiện chất lượng cuộc sống bệnh nhân ung thư. Cần có những biện pháp nâng cao chất lượng cuộc sống của bệnh nhân ung thư trong suốt quá trình điều trị tại bệnh viện và sau khi xuất viện trở về nhà.
Một số kiến thức về dinh dưỡng hợp lý của phụ nữ độ tuổi sinh đẻ tại khu vực ven biển tỉnh Nam Định năm 2020
Authors: Tùng Lê Thanh , Long Trần Văn , Trung Lê Thế , Hương Phạm Thị Thanh , Nhi Trần Thị , Hương Vũ Thị Thanh , Hiền Vũ Thị Thu , Lâm Nguyễn Thị , Vinh Khương Thành
Published: December 2021

Nghiên cứu mô tả cắt ngang nhằm mô tả một số kiến thức về dinh dưỡng hợp lý trên 468 phụ nữ độ tuổi sinh đẻ tại một số huyện ven biển tỉnh Nam Định năm 2020. Kết quả cho thấy tỷ lệ phụ nữ biết về mất cân bằng dinh dưỡng sẽ dẫn đến thiếu năng lượng trường diễn (54,9%), thiếu kẽm (68,2%), thừa cân-béo phì (93,8%) và thiếu máu (93,6%). Tỷ lệ phụ nữ biết đầy đủ các nguyên nhân dẫn đến tình trạng thiếu năng lượng trường diễn, thừa cân - béo phì, thiếu máu, thiếu kẽm còn thấp. Tỷ lệ phụ nữ cho rằng ăn đầy đủ và hợp lý các bữa ăn trong ngày là quan trọng chiếm 57,5%), rất quan trọng chiếm 35,9%. Tỷ lệ hiểu biết về tầm quan trọng của chế độ ăn và ảnh hưởng của nó đến sức khỏe là cao, tuy nhiên tỷ lệ có kiến thức về một số hậu quả mất cân bằng dinh dưỡng và nguyên nhân gây ra nó còn thấp. Cần tăng cường truyền thông nâng cao kiến thức của phụ nữ độ tuổi sinh đẻ trong chăm sóc dinh dưỡng và sức khỏe.
Hiệu quả bổ sung đa vi chất cải thiện tình trạng thiếu máu thiếu sắt của nữ vị thành niên trung học phổ thông miền núi tỉnh Thanh Hóa năm 2019 – 2020
Authors: Hằng Lưu Kim Lệ , Nga Trần Thúy , Phương Nguyễn Thị Lan , Hiệp Nguyễn Xuân
Published: December 2021

Nghiên cứu can thiệp cộng đồng có nhóm đối chứng, mù đôi, đánh giá hiệu quả sử dụng viên đa vi chất (ĐVC) hàng tuần lên tình trạng thiếu máu, thiếu sắt của nữ vị thành niên trung học phổ thông miền núi tỉnh Thanh Hóa năm 2019 – 2020, phân loại chỉ số sinh hóa theo Tổ chức Y tế Thế giới (WHO). 322 nữ học sinh tham gia can thiệp chia ngẫu nhiên thành 2 nhóm, nhóm can thiệp uống viên đa vi chất gồm 23 loại trong đó sắt (60 mg), acid folic (2,8 mg), nhóm chứng uống viên giả dược, 1 viên/tuần trong 9 tháng. Kết quả sau 9 tháng can thiệp, nồng độ hemoglobin trung bình của nhóm can thiệp tăng 8,3 ± 11,8 (g/L); nhóm chứng tăng 3,8 ± 12,3 (g/L) (p < 0,001), nồng độ ferritin trung vị (khoảng tứ phân vị) nhóm can thiệp tăng 6,8 (-2; 22,1) (μg/L) (p < 0,001); nhóm chứng tăng 1,6 (-18,3; 10,5) (p > 0,05). Sự khác biệt nồng độ hemoglobin trung bình và nồng độ ferritin trung vị giữa hai nhóm sau can thiệp có ý nghĩa thống kê (p < 0,05). Như vậy, việc bổ sung đa vi chất dinh dưỡng hàng tuần cho nữ vị thành niên trong 9 tháng có tác dụng cải thiện các chỉ số sinh hóa và tỷ lệ thiếu vi chất dinh dưỡng ở các mức độ khác nhau, dự phòng tốt tình trạng thiếu máu, thiếu sắt.
Hiệu quả nuôi dưỡng bằng dung dịch dinh dưỡng cao năng lượng trên bệnh nhân nặng nuôi ăn qua ống thông tại bệnh viện đa khoa tỉnh Phú Thọ năm 2020
Authors: Hương Nguyễn Thị Lan , Anh Trần Thế , My Hoàng Giáng , Liễu Nguyễn Thị
Published: December 2021

Nghiên cứu mô tả cắt ngang được tiến hành trên 62 bệnh nhân nặng nuôi ăn qua ống thông bằng dung dịch dinh dưỡng cao năng lượng (1,2kcal/1ml) do khoa Dinh dưỡng cung cấp tại bệnh viện đa khoa tỉnh Phú Thọ từ tháng 1/2020 đến tháng 11/2020. Nghiên cứu nhằm mô tả hiệu quả nuôi dưỡng bằng dung dịch dinh dưỡng cao năng lượng trên bệnh nhân nặng nuôi ăn qua ống thông tại Bệnh viện Đa khoa tỉnh Phú Thọ năm 2020. Kết quả: tuổi trung bình nhóm nghiên cứu là 74 tuổi. Tỷ lệ bệnh nhân suy dinh dưỡng (SDD) theo BMI < 18,5 là 48,8%, sau nuôi dưỡng giảm còn 45,2%; theo SGA tỷ lệ bệnh nhân đánh giá SGA-A tăng lên đáng kể từ 48,4% tăng lên 58,1% sau nuôi dưỡng. Cân nặng trung bình trước nghiên cứu là 49,9 ± 7,7 kg sau nghiên cứu tăng 50 ± 7,8 kg. Can thiệp bằng dung dịch nuôi dưỡng làm thay đổi các chỉ số hóa sinh, huyết học trong đó sự thay đổi ure, creatinin và AST có ý nghĩa thống kê (p < 0,05).
Agroecological assessment of saline soils of Iran
Authors:   RGAU-MSHA named after K.A. Timiryazev, Mohammadi Shima
Published: December 2021

For the studied saline soils, the expediency of assessing the content of mobile ion compounds by chemical autography based on electrolysis and ionite membranes, vertical electrical sensing is shown. However, the electrical conductivity of soils depended on humidity, temperature, humus content, granulometric composition, soil density, and fertilizer application. The change in the nature and degree of soil salinization over time and in space was determined not only by the microrelief of the surface, groundwater and the change in the depth of the umbrellas in density, but also by the patterns of solubility of salts from humidity, temperature, pCO2, complex formation. For relative optimization of the situation, it is recommended to apply mineral fertilizers, stimulants, organic fertilizers, and create a large-porous layer at a depth of 40-70 cm, reducing the upward current from the lower layers of the soil to the Ap. Keywords: SOIL, SALINIZATION, WAYS OF OPTIMIZATION
Led simulation lamps with optimal temperature led operation mode
Authors:   State Agrarian Universi ty of the Northern Trans-Urals, Shirobokova Tatiana , Surinsky Dmitry , Egorov Sergey
Published: December 2021

This article deals with the design of LED lamps with an optimal thermal mode of operation of the LEDs used. Thermal analysis of the model was performed using SolidWorks Simulation software. Keywords: LED LAMP, LED, OPTIMAL OPERATING MODE, ANALYSIS
Security and protective electro-deratization system based on machine vision
Authors:   State Agrarian University of the Northern Trans-Urals, Andreev Leonid , Kozlov Alexander
Published: December 2021

The article discusses the prerequisites for the use of machine vision in electrical deratizers, considers the methods and methods of implementation, describes the design principles and composition of security and deratization systems, makes a fundamental approach to the mathematical modeling of the thermal imaging image of the background target environment, and also discusses the installation and maintenance of this system. Keywords: MACHINE VISION, AUTOMATION, CAMERAS, HIGH-SPEED SHOOTING, VIDEO SURVEILLANCE, TECHNICAL VISION, NAVIGATION, DERATIZATION
Zsugorodó városok és társadalmi egyenlőtlenségek Magyarországon
Authors: Jelinek Csaba , Virág Tünde
Published: December 2021

Magyarország népessége 1980 óta csökken, 2001 és 2011 között pedig a magyar városok 75%-ában regisztráltak demográfiai zsugorodást. Közép-Kelet-Európában hasonló folyamatokat figyelhetünk meg. Annak ellenére, hogy az 1970-es évektől egyes egyesült államokbeli, majd 1989 után a kelet-német régiók és városok esetében a „hanyatló” és „zsugorodó” városok társadalomtudományos vizsgálatával több szerző foglalkozott, Magyarországon ezek a fogalmak nem váltak a társadalomtudományos elemzés integráns részévé. Jelen tematikus lapszám bevezetőjeként azt a kérdést járjuk körül, hogy a „városi zsugorodás” hogyan befolyásolja az érintett helyi társadalmak esetében a térbeli-társadalmi egyenlőtlenségeket. A cikk a városi zsugorodást mint empirikus folyamatot tárgyalja, amelyhez a periferializálódással kapcsolatos kritikai irodalmat választja elméleti keretéül. A cikk első felében röviden bemutatjuk a zsugorodással kapcsolatos nemzetközi irodalom egyes főbb állításait, majd áttekintjük a főbb zsugorodási tendenciákat Közép-Kelet-Európában és Magyarországon. Ezután bemutatjuk a lapszám alapjául szolgáló négyéves kutatásunkat, végül pedig röviden összefoglaljuk a lapszám további tanulmányait, amelyek mind a magyarországi kis- és középvárosi zsugorodás egy-egy ambivalens jellemzőjét – a városokon belül a különböző társadalmi csoportok eltérő percepcióit, az átmeneti terekbe történő mobilitás mikroszociológiáját, a zsugorodó városok oktatási piacait, a tanodaprogramok középosztályosítási törekvéseit, illetve a helyi önkormányzatok és a központi kormányzat változó viszonyát – tárgyalják.
Térvakság. Oktatási stratégiák a városi zsugorodás és a tanulói létszám csökkenésének időszakában
Authors: Zolnay János
Published: December 2021

Az iskolák államosítása óta az oktatási intézményeket három, helyi szinten rivalizáló ágens tartja fenn: az állami tankerületek, az egyházak és az óvodákat fenntartó önkormányzatok. Két részletes vizsgálat, illetve adatgyűjtés alapján ez a tanulmány arra a kérdésre keresi a választ, hogy a helyi döntéshozók és intézményigazgatók miként érzékelik és értelmezik a számszerű és funkcionális városi zsugorodás folyamatát egy közepes méretű és egy posztindusztriális válsággal küzdő kisebb városban. A vizsgálat eredményei szerint az iskolafenntartás központosítása és a pedagógusok szakmai autonómiájának szűkítése ellenére az oktatási intézmények feletti közpolitikai kontroll paradox módon gyengült, és helyi szinten közpolitikai vákuum alakult ki. Az oktatási piac eredendő instabilitása, a tanulói ingázás, valamint a konkurens fenntartók rivalizálása miatt a döntéshozók és az intézmények nem érzékelik a városi zsugorodást. Az oktatási intézmények úgy vélik, hogy a tanulói létszám csökkenése ellenére képesek lehetnek megőrizni vagy javítani pozíciójukat a helyi oktatási piacon, ha kellően szelektív és kizáró felvételi gyakorlatot folytatnak.
Kazneno djelo sprječavanja dokazivanja
Authors: Juras Damir , Gulišija Željko
Published: December 2021

Propisivanje kaznenog djela sprječavanja dokazivanja u čl. 306. Kaznenog zakona ima za
cilj moguće počinitelje odvratiti od radnji sprječavanja dokazivanja odnosno
kazniti radi sprječavanja i otežavanja dokazivanja u sudskim i drugim
postupcima jer se takvim radnjama otežava i usporava donošenje pravilne i
pravovremene odluke. Ovo kazneno djelo ima tri oblika. Prvim oblikom kažnjava se svaka osoba koja prema
pretpostavljenom svjedoku, svjedoku ili vještaku u nekom službenom postupku
uporabi silu, prijetnju ili drugi oblik prisile, ili nudi, obeća ili dade dar
ili kakvu drugu korist, s ciljem da ga navede na davanje lažnog iskaza ili da
spriječi ili oteža dokazivanje. Drugi oblik čini se skrivanjem, oštećenjem ili
uništenjem predmeta ili isprave koji služe dokazivanju ili krivotvorenjem
dokaza u postupku pred nadležnim tijelom ili predočenjem krivotvorine kao
dokaza u postupku. Ovaj oblik djela može se počiniti samo u postupku pred
sudom, a ne prije nego je postupak započet. Treći oblik čini tko ukloni,
uništi, pomakne granični kamen, zemljomjerski znak ili drugi znak o vlasništvu
ili lažno postavi takav znak. Ovo djelo može počiniti svaka osoba. Zakon za sva
tri oblika djela navodi „s ciljem“ iz čega proizlazi da se djelo može počiniti
samo s izravnom namjerom.
Značajke tržišta automobila s posebnim osvrtom na tržište električnih vozila
Authors: Višić Josipa , Stanić Ivana
Published: December 2021

Od izuma automobila automobilska
industrija generator je brojnih tehnoloških unaprjeđenja koja se, uslijed
nužnog praćenja smjernica za zaštitu okoliša i ograničenih energetskih resursa,
sve više okreću električnoj energiji. U tom smislu električni automobili
predstavljaju važan segment promatranog tržišta, a s vremenom se očekuje i
potpuno usmjeravanje proizvodnih aktera prema ovoj vrsti vozila. Slijedom
navedenog, u radu se istražuju značajke automobilskog tržišta s posebnim naglaskom
na tržište električnih automobila. Rezultati istraživanja za razdoblje od 2010.
do 2020. temeljeni na podacima sa stranica Companies market cap te Statista pokazuju
da vrijednost cijene dionica poduzeća na promatranom tržištu nije u svakoj
promatranoj godini povezana s brojem prodanih automobila, što je analizirano
Pearsonovim koeficijentom korelacije. No, promatranjem Herfindahl-Hirschmanovog
indeksa te koncentracijskog omjera (CR4) izračunatih na temelju
podataka sa stranice Knoema evidentno je da tržišna utakmica prisiljava
najznačajnije sudionike na tržištu automobila s unutarnjim izgaranjem na brzo
restrukturiranje i fokusiranje na električne automobile kako ne bi izgubili
postojeći tržišni udio. Naposljetku, regresijskom analizom provedenom na podacima
prikupljenim sa stanice International Energy Agency dokazuje se da je cijena
baterije po kilovat satu jedan od važnih čimbenika u razvoju industrije
električnih automobila, dok deskriptivna analiza pruža detaljan uvid u dodatne varijable
koje determiniraju razinu prodaje električnih automobila.
Corporate Social Responsibility Implemented by SA8000 Standard in Italy
Authors: Abramuszkinová Pavlíková Eva , Basovníková Marcela , Huber Peter
Published: December 2021

n this paper, corporate social responsibility (CSR) adoption is measured by the implementation of SA8000 certification. This is one of the internationally most widely used social accountability standards for retailers, brand companies, suppliers and other organizations.
Impact of Innovative Information Technologies and Systems on Achieving Financial and Process Effects of a Company
Authors: BOLEK Vladimír , ZELINA Michal
Published: December 2021

In the last decade, measuring the effectiveness and the effects of information and communication technologies has become a very important issue for companies. Company managers often argue over the effects achieved by integrating innovative information technologies and systems.
Understanding the Changes in the Tourists Perceived Risk after Covid-19
Authors: GARCEZ Ana , Fontes CORREIA Ricardo , COSTA Adriano
Published: December 2021

Tourism industry is witnessing a time of uncertainty due to the Covid-19 pandemic. Amidst all the doubts that the industry is experiencing, one certainty is clear: nothing will remain the same after the pandemic outbreak. Tourists have developed new needs that the industry of tourism should be able to understand and fulfill.
Employee Engagement: An Actual Theme, in a Permanent Evolution
Authors: MARIN Radu
Published: December 2021

Modern companies are well aware of the fact that employee engagement can contribute, in a decisive manner, to the company’s competitiveness and performance. This paper’s purpose is to analyse how employees’ engagement was defined over time in the literature, in order to highlight the methods by which employees’ engagement can be determined, to identify the factors that lead to employee engagement, and to highlight how a successful employee engagement program can be developed.
Management of Local Heat Poverty in Households – on the Selected Example
Authors: ŚWIERSZCZ Katarzyna
Published: December 2021

The reason for writing the article is the phenomenon of heat energy poverty among households. This problem is experienced both in Poland and other more or less developed European countries. Its main cause is three elements: economic, technical and social. Research shows that local governments responsible for the effective management of energy security are beginning to notice the problem of heat poverty in local terms.
Evaluation of Magnetic Resonance Imaging of the Chest at a Cancer Center
Authors: Duarte Braga Juliana Cristina , Fábio Dias Teixeira Diogo , Hochhegger Bruno , Rydz Pablo , Luiz Gross Jefferson , Jose Haddad Fabio , Rosa Naue Carine , Duarte Guimarães Marcos
Published: December 2021

Objective: In the present article, we will describe the indications for chest MRI in patients diagnosed with malignancy and its relevant role in distinguishing benign from malignant lesions and in detecting metastases.  Materials and methods: Single-center, retrospective, analytical imaging and chart-review study of all patients with a diagnosis of cancer who underwent chest MRI at the Imaging Department of A.C. Camargo Cancer Center from January 2014 through December 2016. Information was collected through an electronic questionnaire and exported to a Microsoft Excel spreadsheet. Data were then processed in Action Stat 3 software. Descriptive analysis was conducted with conventional measures of central tendency (mean, median, mode) and dispersion (range, variance, standard deviation, and coefficient of variation), as well as calculation of absolute and relative frequencies. Results: The leading indication for chest MRI was post-treatment follow-up. Chest MRI was most often requested by the Departments of Thoracic Surgery and Clinical Oncology. In most cases, the results of chest MRI led to maintenance of the current treatment plan rather than a change in management. Conclusion: Magnetic resonance imaging has several applications in evaluation of the chest, and can be used by various specialties and subspecialties. In the present study, post-treatment follow-up and maintenance of current therapy were the most common indication and management, respectively.
Observatório dos acidentes de transporte terrestre atendidos pelo Serviço de Atendimento Móvel de Urgência no interior de Pernambuco
Authors: Santos Thiago das Virgens , Ferreira Jessica Leticia Rodrigues , Trindade Joanis Silva , Silva Alane Macedo da , Ferreira Filho Antônio Roberto , Souto Silva Denilça , Silva Cristiane Nunes da , Martins Victor Hugo da Silva
Published: December 2021

Os acidentes de transporte terrestre (ATT) ceifam milhares de vidas todos os anos, do mesmo modo que provocam sequelas importantes e permanentes em várias pessoas durante seu curso existencial, tendo como fatores contribuintes o uso de substâncias que alteram o nível de consciência e a imprudência nas estradas. O presente estudo objetiva-se caracterizar os ATT da cidade de Petrolina/PE, a partir da demanda atendida pelo Serviço de Atendimento Móvel de Urgência (SAMU). Trata-se de um estudo descritivo sobre acidentes ocorridos no município, alicerçado pelo total de ocorrências atendidas pelo SAMU do município durante o período de 2018. As informações foram coletadas da base de dados do SAMU. A cidade fica localizada no interior de Pernambuco e tem um grande volume de chamados para atendimento de ATT, sendo considerado um fator alarmante, haja vista que é classificado como um sério problema de saúde pública no mundo. Verifica-se que o pedido para prestação de socorro para os motociclistas tem prevalência superior a 70% em relação ao número total de ocorrências, com destaque numérico em todos os meses de 2018. Nesse sentido é necessária a adoção de medidas efetivas quanto a educação no trânsito para a comunidade, na elaboração de normas, bem como a co-responsabilização e colaboração de outros setores e comunidade, no intuito de amortizar os índices de acidentes, sequelas e óbitos.
Flow cytometric analysis of the inhibition of human basophil activation by histamine high dilutions - a replication study
Authors: Wälchli Chantal , Baumgartner Stephan
Published: December 2021

Background: Inhibition of human basophil activation by highly diluted histamine was reported to be a reliable experimental model to examine biological effects of high dilutions. However, independent replications did not always yield concordant results.

Aims: We aimed at performing an independent replication of a former study [1] using rigorously controlled experimental conditions to minimise confounding factors.

Materials and Methods: In 20 independent experiments, human basophils were treated with highly diluted histamine (15cH, 16cH, corresponding to 10-30-10-32 M) prior to activation by fMLP (formyl-methionyl-leucyl-phenylalanine peptide). Controls were treated with analogously diluted water (15cH, 16cH). The dilutions were prepared freshly for each experiment in deionised water by successive steps of centesimal dilution and agitation (10 s vortex at high speed). Highly diluted samples were blinded and randomised. All samples were set in triplicates. Activated basophils were determined by flow cytometry using anti-CD203c. 20 independent systematic negative control (SNC) experiments were carried out to investigate possible systematic errors.

Results: No difference in basophil activation was observed between the highly diluted histamine samples and the highly diluted water controls. There was no evidence for a blood donor specificity of the results. The SNC experiments demonstrated the stability of the test system. Experimental variability within and between experiments was slightly reduced for the highly diluted histamine samples.

Discussion: This study was designed as an independent reproduction of a former study [1]. Though we strictly adopted the experimental procedure described in [1], our results do not confirm the large inhibitory effects observed for histamine 15cH and 16cH. This lack of reproducibility might be due to minor differences in the experimental design, such as blinding and randomising of the samples, which we chose to perform in order to reduce the possibility of artifacts but was omitted in the former study.

Conclusions: Laboratory independent replication of homeopathic basic research experiments is still a challenge. Assuming that the results formerly obtained with this model were not due to systematic errors, the quest identifying the crucial factors for successful reproducibility is open for future research.

Keywords: Human basophils; histamine; high dilutions; flow cytometry

Reference:

[1] Sainte-Laudy J, Belon P. Improvement of flow cytometric analysis of basophil activation inhibition by high histamine dilutions. A novel basophil specific marker: CD 203c. Homeopathy. 2006;95:3-8.
Highly diluted compounds effects on B16-F10 melanogenesis, reactive oxygen species (ROS) production and tumorigenesis.
Authors: Potrich Francine Bittencourt , Wippel Helisa , De Oliveira Simone Martins , Buchi Dorly de Freitas , De Oliveira Carolina Camargo , Trindade Edvaldo da Silva
Published: December 2021

Background: Cutaneous melanoma is a highly malignant tumor derived from pigment-producing (melanin) melanocytes of skin epidermis. Cutaneous pigmentation is described as the major physiologic defense against UV radiation. During melanin biosynthesis and other tumorigenic process, reactive oxygen species (ROS) are produced and might be critically involved in several melanomagenesis stages. ROS play key roles on regulation of many types cell proliferation, including melanoma cells. Aims: In this work we evaluated the effects of highly diluted compounds on melanogenesis and changes in reactive oxygen species after 96 hours of treatment and possible involvement in tumorigenesis. Methodology: Melanin content was measured in B16-F10 cells after 96 hours of treatment with highly diluted compounds, as well as the superoxide anion, hydrogen peroxide and nitric oxide. Furthermore, the effects of highly diluted compounds on cell proliferation were investigated by trypan blue exclusion method after 48 hours of treatment. Results: Treatment led to an increase in B16-F10 melanin content and a decrease in nitrite concentration, an intermediate product of nitric oxide. We also observed a decrease in cell proliferation after treatment. It is well recognized that nitric oxide (NO) is involved in tumor progression, including melanoma. Several articles show that NO treated B16-F10 cells exhibited higher metastatic capacity. Thereby, reduction in cell proliferation can be due to low NO levels. It is speculated that melanocytes are programmed to survive in order to preserve their photoprotective role, thus in a compensatory manner the cell may be synthesizing melanin in response to cell proliferation reduction. Conclusions: These results suggest that treatment may be reducing tumorigenic capacity via ROS reduction. However further studies are need to better understand highly diluted compounds mechanisms of action.
Biochemical responses induced by Biotherapics prepared from intact influenza A (H3N2) and inactivated influenza A (H3N2) virus at 12x and 30x in MDCK cells and RAW-264-7 macrophages
Authors: Siqueira Camila , De MendonÃƒÆ’Ã‚Â§a Rafaela , Da Veiga Venício , Marcondes Mariah , Grechi Juliana , Jardim-Messeder Douglas , Zancan Patricia , Galina Antonio , Couceiro JosÃƒÆ’Ã‚Â© Nelson , Holandino Carla
Published: December 2021

Background: "Roberto CostaÃƒÂ¢Ã¢â€šÂ¬Ã¢â€žÂ¢s Biotherapics" are homeopathic remedies prepared from intact microorganisms which have been proposed for treatment of diseases like influenza.

Aim: This study aimed to compare the biochemical effects, in MDCK cells and RAW-264-7 macrophages, of biotherapics prepared from intact influenza virus diluted in water as well as from a sample of the same virus inactivated by ethanol 70% (v / v), both in the homeopathic potencies of 12x and 30x. Water 30x, non-dynamized water and cells without treatment (control cells) were used as control.

Methodology: Treatments were performed by incubating MDCK cells with DMEM medium added in a 1:10 ratio for 6 times (3 different aliquots per day) or 18 times (up to 4 aliquots per day) in each experimental situation. Each aliquot was added with an interval of at least 2 hours. After that, the mitochondrial activity of MDCK cells was analyzed by MTT assay. The effects of treatments with intact biotherapics on MDCK cells respiratory parameters were studied using high resolution respirometry (Oroboros Oxygraph-O2K). RAW-264-7 macrophages were treated with intact and inactivated biotherapic 30x (4 treatments, 24 hours) to verify the nitric oxide production. These macrophages were also submitted to MTT assay.

Results: Both biotherapic preparations 1x (intact and inactivated virus sample) were analyzed by transmission electronic microscopy. The presence of virus particles was detected when water was used as solvent. The use of ethanol as biotherapic solvent induced complete virus lysis. There was no alteration in cell osmolarity revealed by neutral red assay, when 10% of each test solution was used. Cellular viability analyzed by MTT method increased when MDCK cells were treated with 18 stimuli of inactivated biotherapic 30x when compared to intact biotherapic 30x (p0.05) were detected when these cells were compared to control cells.

The maximum respiratory capacity of MDCK cells increased after treatment with 18 stimuli of intact biotherapic 30x when compared to control cells. However, no statistically significant differences (p>0.05) induced by biotherapics in macrophage cells were observed by MTT and nitric oxide assays. Moreover, a reduction in nitric oxide was observed in macrophages treated with dynamized water when compared to control cells.

Conclusions: These results indicate that the method of biotherapic compounding (intact or inactivated virus as starting point) can modify the cellular parameters with the tendency to increase cellular response with longer treatments and higher potencies.
The drivers and health risks of unexpected surface ozone enhancements over the Sichuan Basin, China, in 2020
Authors: Sun Youwen , Yin Hao , Lu Xiao , Notholt Justus , Palm Mathias , Liu Cheng , Tian Yuan , Zheng Bo
Published: December 2021

Abstract. Following a continuous increase in the surface ozone (O3) level from 2013 to
2019, the overall summertime O3 concentrations across China showed a
significant reduction in 2020. In contrast to this overall reduction in
surface O3 across China, unexpected surface O3 enhancements of
10.2 ± 0.8 ppbv (23.4 %) were observed in May–June 2020 (relative to 2019)
over the Sichuan Basin (SCB), China. In this study, we use high-resolution
nested-grid GEOS-Chem simulation, the eXtreme Gradient Boosting (XGBoost)
machine learning method, and the exposure–response relationship to
determine the drivers and evaluate the health risks due to the unexpected
surface O3 enhancements. We first use the XGBoost machine learning
method to correct the GEOS-Chem model–measurement O3 discrepancy
over the SCB. The relative contributions of meteorology and anthropogenic
emission changes to the unexpected surface O3 enhancements are then
quantified with a combination of GEOS-Chem and XGBoost models. In order to
assess the health risks caused by the unexpected O3 enhancements over
the SCB, total premature mortalities are estimated. The results show
that changes in anthropogenic emissions caused a 0.9 ± 0.1 ppbv
O3 reduction, whereas changes in meteorology caused an 11.1 ± 0.7 ppbv
O3 increase in May–June 2020 relative to 2019. The meteorology-induced surface
O3 increase is mainly attributed to an increase in temperature and decreases in precipitation, specific humidity, and cloud fractions over
the SCB and surrounding regions in May–June 2020 relative to 2019. These changes in
meteorology combined with the complex basin effect enhance biogenic
emissions of volatile organic compounds (VOCs) and nitrogen oxides
(NOx), speed up O3 chemical production, and inhibit the
ventilation of O3 and its precursors; therefore, they account for the
surface O3 enhancements over the SCB. The total premature mortality due
to the unexpected surface O3 enhancements over the SCB has increased by
89.8 % in May–June 2020 relative to 2019.
The role of anthropogenic aerosols in the anomalous cooling from 1960 to 1990 in the CMIP6 Earth system models
Authors: Zhang Jie , Furtado Kalli , Turnock Steven T. , Mulcahy Jane P. , Wilcox Laura J. , Booth Ben B. , Sexton David , Wu Tongwen , Zhang Fang , Liu Qianxia
Published: December 2021

Abstract. The Earth system models (ESMs) that participated in the sixth Coupled Model Intercomparison Project (CMIP6) tend to simulate excessive cooling in
surface air temperature (TAS) between 1960 and 1990. The anomalous cooling is pronounced over the Northern Hemisphere (NH) midlatitudes, coinciding
with the rapid growth of anthropogenic sulfur dioxide (SO2) emissions, the primary precursor of atmospheric sulfate aerosols. Structural uncertainties between ESMs have a larger impact on the anomalous cooling than internal variability. Historical simulations with and without
anthropogenic aerosol emissions indicate that the anomalous cooling in the ESMs is attributed to the higher aerosol burden in these models. The
aerosol forcing sensitivity, estimated as the outgoing shortwave radiation (OSR) response to aerosol concentration changes, cannot well explain the diversity of pothole cooling (PHC) biases in the ESMs. The relative contributions to aerosol forcing sensitivity from aerosol–radiation interactions (ARIs) and aerosol–cloud interactions (ACIs) can be estimated from CMIP6 simulations. We show that even when the aerosol forcing sensitivity is similar between ESMs, the relative contributions of ARI and ACI may be substantially different. The ACI accounts for between 64 % and 87 % of the aerosol forcing sensitivity in the models and is the main source of the aerosol forcing sensitivity differences between the ESMs. The ACI can be further decomposed into a cloud-amount term (which depends linearly on cloud fraction) and a cloud-albedo term (which is independent of cloud fraction, to the first order), with the cloud-amount term accounting for most of the inter-model differences.
Representatives of the von Hattstein family asclerks of the Order
of Teutonic Knights in Prussia. Historical-legal and genealogical school
Authors: Kruszewski Tomasz
Published: December 2021

The author is showing the history of the important gentry family from Hesse, of which numerous
representatives came to the monastic state in Prussia.This paper has a double character, is linking deliberations
of genealogical issues with the historical-legal presentation. The last is necessary at discussing offices and
their competence, in relation to persons from the von Hattstein family who held them. The special place was
devoted Kuno von Hattsteinowi, which in the end one of the highest monastic offices, that is the office of the
Great Marshal performed the 14th century. Genealogical tables are complementing the work.
Work on the edition of the minutes of the meetings in Frombork Cathedral Chapter from the time of Copernicus
Authors: Makarczyk Irena
Published: December 2021

The proceedings of the Chapter from the times of Copernicus were thoroughly discussed by prof.
Alojzy Szorc. Here we present only the most important issues related to their editing. These protocols can be
found in the Archives of the Archdiocese of Warmia in Olsztyn, in three small books. Represent only a small
part of the contents of individual books, the rest are documents from later times, or of any other nature. The
issues contained in them, the current issues discussed at the meetings of the Chapter. They create a picture
of life Canons of Warmia, including Nicolaus Copernicus. His name appears in the minutes several times, in
situations of quite ordinary.
On the change of the calendar in Ducal Prussia in 1612
Authors: Białuński Grzegorz
Published: December 2021

Sprawa zamiany kalendarza juliańskiego na gregoriański w Prusach Książęcych nie doczekała
się jak do tej pory oddzielnego omówienia. Problem to z pozoru prosty, wywoływał jednak
w dotychczasowej literaturze spore zamieszanie. Józef Szymański w podstawowej pracy o naukach
pomocniczych historii podaje co prawda informację o zamianie kalendarza, ale z błędną
datą, mianowicie 1610 r. Natomiast wydawca pracy Maxa Toeppena Historia Mazur podaje
datę 1700 r., kiedy to rzeczywiście wprowadzono kalendarz gregoriański, ale w protestanckich
krajach niemieckich. Przy tym samego Toeppena problem ten nie interesował i daty podawał
za dokumentami, nie zmieniając ich na kalendarz gregoriański. Tak postępowała większość
badaczy niemieckich, a za nimi też polscy. Powoduje to jednak, że daty między 1582 a 1612 r.
podawane są na ogół według kalendarza juliańskiego i wiele z nich należy zweryfikować. Takim
przykładem jest m.in. datacja lokacji miasta Leca (Giżycka) w maju 1612 r.
Effect of Farmer Field School (FFS) on the Knowledge, Attitude, Practices and Profitability of Rice Farmers
Authors: Red Froline S. , Amestoso Nilda T. , Casinillo Leomarich F.
Published: December 2021

Knowledge, Attitude and Practice (KAP) Model explains the individual’s knowledge which affects attitude and consequently changes the actual practices. The study investigated the effect of the Farmer Field School (FFS) on the knowledge, attitude, practices, and profitability of rice farmers in Babatngon, Leyte, Philippines. Ninety-four participants, which included 47 FFS farmers and 47 non-FFS farmers, were randomly chosen. Data were analyzed using descriptive and comparative statistics, cost and return analysis, and multiple regression analysis. Results showed that FFS farmers have a significantly higher level of knowledge than non-FFS farmers in the Palaycheck System (p-value<0.001). Additionally, FFS farmers have a significantly great extent of practice than non-FSS farmers in the Palaycheck System (p-value<0.001). Furthermore, farmers with high knowledge, positive attitude, and the great extent of practice on Palaycheck system gain more profit. Therefore, farmers should acquire more knowledge, a positive attitude, and more practice on production technologies to increase profit. Farmer Field Schools (FFS) and demonstration farms should be established in multi-locations to highlight the benefits of the Palaycheck technology for widespread adoption.
Readings in Philippine History: Course Review, Best Practices, and Challenges among Higher Education Institutions
Authors: Alic Alvin Kris B. , Bual Joel M.
Published: December 2021

History is essential in the curriculum. The Readings in Philippine History (RPH) syllabus and instruction should be advanced. However, curricular changes and the pandemic affected the instruction. Thus, this study reviewed the course specification and syllabus of RPH among higher educational institutions in Kabankalan City, Philippines. Anchored on the CHED recommended syllabus in RPH, the study reviewed the course and determined the areas for improvement. Likewise, it identified the best practices and challenges. Using a descriptive design and employing purposive and stratified sampling, 269 external reviewers, teachers, and students reviewed the study. The mean, frequency count, rank, and percentage distribution were employed in data analysis. Generally, the course adheres to the standard. However, the main issue is students' learning readiness and the misalignment of teachers' specialization. Thus, a strong foundation on Philippine History among the students is necessary to ensure quality. Also, the retention of qualified teachers is essential in advancing the instruction.
Wounded Healers: Coping with Vicarious Trauma among Mental Health Professionals
Authors: Salvilla Graziela B. , Bedoria Chris John S.
Published: December 2021

Mental health professionals have been experiencing vicarious trauma due to their exposure to trauma-related cases. This study explored the coping strategies used by mental health professionals in dealing with vicarious trauma. A purposive sample of five (5) mental health professionals participated in this study. The study utilized Narrative Inquiry and Thematic Analysis to explore the stories of handling trauma cases and construct the central themes of coping strategies from vicarious trauma among mental health professionals. Findings of the study generated six central themes: a) recognition of experienced vicarious trauma symptoms, b) healthy personal and working relationships, c) fulfilling self-preserving needs, d) regulation of thought processes, e) professional competence and due care, and f) fate and faith. The results provided a holistic approach to vicarious trauma that targeted all dimensions of an individual; emotional, physiological, cognitive, occupational, and spiritual.
Spiritual Well-Being of Senior High School Students of Philippine Public Schools
Authors: Cena Joehally B. , Bual Joel M.
Published: December 2021

Spirituality is essential among students in their pursuit of meaning and beliefs. However, in public schools, values and religious education are less focused, compromising students' spiritual well-being. Thus, this study assessed the degree of spiritual well-being of senior high school students of public schools in Bacolod City, Philippines in terms of religious and existential well-being. It also compared the spiritual, religious, and existential well-being assessments. A quantitative design gathered the data from 335 students. Using the descriptive and inferential analyses, the results revealed that the students' spiritual well-being was moderate. Also, their religious well-being is high, while existential well-being is moderate. It indicates the need to effectively hone the students’ values to recognize their life’s purpose and satisfaction. Meanwhile, there was no difference in their spiritual, religious, and existential well-being. Thus, values and religious formations are highly encouraged to guarantee the students’ spiritual well-being.
Las Zonas Arqueológicas en la legislación canaria de patrimonio cultural. Implicaciones para la gestión de su protección
Authors: Morales Casañas Diria , Pérez González Elena María
Published: December 2021

En la actualidad, en las Islas Canarias se encuentran declarados 83 Bienes de Interés Cultural (BIC) con categoría de Zona Arqueológica (ZA). De ellos, 36 se encuentran en la isla de Gran Canaria, seguida por Tenerife con 27, Fuerteventura y La Palma con 5 zonas, el Hierro con 3, la Gomera con 2 y finalmente, Lanzarote con sólo una zona arqueológica. En este trabajo se reflejan algunas de las deficiencias en la gestión de este tipo de bienes, ocasionadas por el propio procedimiento de declaración, y que impiden una clara y fluida gestión del patrimonio arqueológico cuyo objetivo debería ser, a tenor de las más actuales tendencias en la gestión patrimonial, integrar, cohesionar y desarrollar social y económicamente los territorios. Para ello, se ha centrado el estudio en el análisis de la organización legal y administrativa en la gestión del patrimonio arqueológico, la política de autorizaciones de las intervenciones arqueológicas, la de protección reflejada en los BIC, la delimitación de áreas de protección y su conversión en parque arqueológico, lo que nos han ayudado a profundizar y mostrar el estado actual de los bienes arqueológicos canarios y avanzar en la evaluación y diagnóstico de la gestión del patrimonio arqueológico.
La ciudad que somos: condición corresponsable para un espacio dialógico en la gestión patrimonial
Authors: Rodríguez Basulto Beatriz , Menéndez Castro Sonia
Published: December 2021

En la actualidad en el marco de las Ciencias Sociales se ha consolidado una razón que reconoce el carácter político de todos los sistemas de ideas que construimos. El llamado a la transformación política de todas las maneras de entender, hacer y difundir el conocimiento histórico/cultural es hoy una tarea de primer orden y creemos que esto conlleva ante todo a la concientización del rol ciudadano dentro de este proceso tanto a escala individual como colectiva. El trabajo que se presenta se centra en los resultados prácticos obtenidos del desarrollo de un estudio comunitario de percepción de las políticas patrimoniales museológicas, insertado a un esquema teórico metodológico alternativo de enfoque dialéctico. A través de esta herramienta se busca el entendimiento -en el contexto actual local/global- de las políticas de musealización y el trabajo comunitario desarrolladas por el Museo de Arqueología de la Oficina del Historiador de La Habana, específicamente de las destinadas a difundir entre los niños y las niñas el patrimonio arqueológico en La Habana Vieja.
El plan arqueológico director de la cuenca del Navia. Balance de tres lustros de actividad arqueológica continuada en el Occidente de Asturias
Authors: Villa Valdés Ángel
Published: December 2021

El Plan Arqueológico Director de la Cuenca del Navia es el documento por el que el Principado de Asturias ordenó entre 1997 y 2009 las intervenciones sobre el patrimonio arqueológico de los territorios del Navia-Eo, en el extremo occidental de la región. Hasta entonces, a pesar del esfuerzo económico realizado por el Gobierno Regional, los resultados no fueron en estas comarcas demasiado satisfactorios en materia de conservación del patrimonio histórico por la carencia de un proyecto que definiese los objetivos y un modelo de gestión adecuado.  Por esta razón se encargó un plan director que estableciese las prioridades de intervención arqueológica en sus diversas facetas: conservación, investigación y difusión. En la presente comunicación se dará cuenta de los criterios empleados en la selección de objetivos, del tipo de intervenciones propuestas y de las vías de financiación utilizadas. Asimismo se expondrán los avances producidos mientras el plan se mantuvo vigente y las causas que motivaron su abrupta interrupción.
La villa romana de Portmán (Cartagena-La Unión). Propuestas para un futuro parque arqueológico
Authors: Fernández Díaz Alicia , González Vergara Óscar , Castillo Alcántara Gonzalo
Published: December 2021

Las excavaciones en la villa romana de Portmán (Cartagena-La Unión, Murcia), han permitido recuperar un gran número de vestigios materiales y nuevos espacios tanto domésticos como de producción y almacenamiento con los que conocer mejor la complejidad y diversidad de usos de la misma. Estas intervenciones sitúan a la villa como una de las más importantes de la región tanto por su cronología, morfología y estructuras, como por su programa ornamental. No obstante, las particularidades administrativas del yacimiento, de propiedad estatal, pero de competencias transferidas a la Comunidad Autónoma y en un término municipal que no se corresponde con el sitio físico/geográfico, han dificultado una actuación ordenada y planificada en el tiempo, que solo desde 2015 ha sido posible con los trabajos realizados desde la Universidad de Murcia. El objetivo de este trabajo es plantear una estrategia de puesta en valor atendiendo a sus características y necesidades, partiendo de la base de las estrategias museográficas y de conservación y difusión actuales que se vienen aplicando también en otros parques arqueológicos y museos de la región.
La valorización del yacimiento arqueológico de la Motilla del Azuer (Daimiel, Ciudad Real) a través de las nuevas tecnologías
Authors: Torres Mas Miguel , López Tercero Julio , López-Menchero Bendicho Víctor Manuel , Torrejón Valdelomar Juan , Maschner Herbert D.G.
Published: December 2021

La aplicación de nuevas tecnologías en el campo del patrimonio arqueológico está generando la incorporación de diferentes perspectivas con respecto a su proyección, puesto que por un lado permite recoger datos desde distintas lecturas y niveles, al tiempo que ofrece fórmulas novedosas con respecto a su valorización integral.

En las siguientes líneas se va a efectuar una descripción pormenorizada de los diferentes trabajos llevados a cabo dentro de la actividad “Motilla Virtual”. Este proyecto se desarrolla a partir de un conjunto  de actuaciones  que van desde la digitalización 3D de todo su recinto, el diseño de una visita a través de realidad virtual, estudios de termografía y geofísica de todo el conjunto, así como trabajos de reconstrucción virtual del asentamiento durante la Edad del Bronce. De igual manera, se presentan de forma detallada los métodos elegidos, recursos empleados y resultados obtenidos, describiendo todos los aspectos o utilidades que se han puesto en funcionamiento dentro de este proyecto. Estas herramientas han permitido avanzar en la investigación, documentación, conservación y valorización de este monumento prehistórico.