bluuebunny/crossref_metadata_2025 huggingface dataset:
Highly effective and chemically stable surface enhanced Raman scattering substrates with flower-like 3D Ag-Au hetero-nanostructures
Authors: Zhang Ying , Yang Chengliang , Xue Bin , Peng Zenghui , Cao Zhaoliang , Mu Quanquan , Xuan Li
Published: January 2018

We demonstrated flower-like 3D Ag-Au hetero-nanostructures on an indium tin oxide glass (ITO glass) for surface enhanced Raman scattering (SERS) applications. The flower-like 3D Ag nanostructures were obtained through electrodeposition with liquid crystalline soft template which is simple, controllable and cost effective. The flower-like 3D Ag-Au hetero-nanostructures were further fabricated by galvanic replacement reaction of gold (III) chloride trihydrate (HAuCl4·3H2O) solution and flower-like Ag. The flower-like Ag-Au hetero-nanostructure exhibited stronger SERS effects and better chemical stability compared with flower-like Ag nanostructure. The localized surface plasmon resonance (LSPR) spectra, field emission scanning electron microscope (FESEM) photos and Ag-Au ratios were studied which show that the surface morphology and shape of the flower-like Ag-Au hetero-nanostructure play significant roles in enhancing SERS. The flower-like 3D Ag-Au hetero-nanostructures fabricated by electrodeposition in liquid crystalline template and galvanic replacement reaction are simple, cheap, controllable and chemical stable. It is a good candidate for applications in SERS detection and imaging.
Identification of JAZ-interacting MYC transcription factors involved in latex drainage in Hevea brasiliensis
Authors: Zhai Jinling , Hao Hui , Xiao Hua , Cao Yuxin , Lin Xiangui , Huang Xi
Published: January 2018

Hevea brasiliensisMüll. Arg. is one of the most frequently wounded plants worldwide. Expelling latex upon mechanical injury is a wound response of rubber trees. However, JA-mediated wound responses in rubber trees are not well documented. In this work, three JAZ-interacting MYC transcription factors ofH. brasiliensis(termed HbMYC2/3/4) were identified by yeast two-hybrid screening. HbMYC2/3/4 each showed specific interaction profiles with HbJAZs. HbMYC2/3/4 each localized in the nucleus and exhibited strong transcriptional activity. To identify the target genes potentially regulated by HbMYC2/3/4,cis-elements interacting with HbMYC2/3/4 were first screened by yeast one-hybrid assays; the results indicated that HbMYC2/3/4 each could bind G-box elements. Additional analysis confirmed that HbMYC2/3/4 bound theHbPIP2;1promoter, which contains five G-boxcis-elements, and regulated the expression of reporter genes in yeast cells andin planta. HbMYC2/3/4were induced by exogenous JA treatment but suppressed by ethylene (ET) treatment; in contrast,HbPIP2;1was positively regulated by ET but negatively regulated by JA treatment. Given thatHbPIP2;1is involved in latex drainage, it could be proposed that HbMYC2/3/4 are involved in the regulation ofHbPIP2;1expression as well as latex drainage, both of which are coordinated by the JA and ET signalling pathways.
Mitochondrial DNA damage and subsequent activation of Z-DNA binding protein 1 links oxidative stress to inflammation in epithelial cells
Authors: Szczesny Bartosz , Marcatti Michela , Ahmad Akbar , Montalbano Mauro , Brunyánszki Attila , Bibli Sofia-Iris , Papapetropoulos Andreas , Szabo Csaba
Published: January 2018

This report identifies mitochondrial DNA (mtDNA) as a target and active mediator that links low-level oxidative stress to inflammatory response in pulmonary epithelial cells. Extrusion of mtDNA into the bronchoalveolar lavage fluid occurs as an early event in mice subjected to cigarette smoke injury, concomitantly with the depletion of mtDNA in the lung tissue. In cultured lung epithelial cells, prolonged, low-level oxidative stress damages the mtDNA, without any detectable damage to the nuclear DNA. In turn, cellular depletion of the mtDNA occurs, together with a transient remodeling of cellular bioenergetics and morphology - all without any detectable impairment in overall cell viability. Damaged mtDNA first enters the cytoplasm, where it binds to Z-DNA binding protein 1 (ZBP1) and triggers inflammation via the TANK-binding kinase 1 /interferon regulatory factor 3 signaling pathway. Fragments of the mtDNA are subsequently released into the extracellular space via exosomes. MtDNA-containing exosomes are capable of inducing an inflammatory response in naïve (non-oxidatively stressed) epithelial cells. In vivo, administration of isolated mtDNA into the in lungs of naïve mice induces the production of pro-inflammatory mediators, without histopathologic evidence of tissue injury. We propose that mtDNA-specific damage, and subsequent activation of the ZBP1 pathway, is a mechanism that links prolonged, low-level oxidative stress to autocrine and paracrine inflammation during the early stages of inflammatory lung disease.
Improving survival of acute-on-chronic liver failure patients complicated with invasive pulmonary aspergillosis
Authors: Gao Jie , Zhang Qing , Wu Yuankui , Li Ying , Qi Tingting , Zhu Congyan , Liu Sijia , Yu Ruoxi , He Qinjun , Wen Weiqun , Zhou Fuyuan , Chen Yongpeng , Chen Jinjun , Hou Jinlin
Published: January 2018

The mortality of acute-on-chronic liver failure (ACLF) patients complicated with invasive pulmonary aspergillosis (IPA) was extremely high. We aimed to explore prognostic value of the Chronic Liver Failure-Sequential Organ Failure Assessment (CLIF-SOFA) lung score and to establish an optimal voriconazole regimen for ACLF patients complicated with IPA. We retrospectively screened hospitalized ACLF patients in our hospital from July 2011 to April 2016, from which 20 probable IPA cases were diagnosed. Along with onsets of IPA, deteriorated diseases severity, especially lung conditions were found in those 20 ACLF patients. It was found that IPA patients with CLIF-SOFA lung score <2 had better 28-day survival than those with lung score >1 (11/13 vs 0/7, p < 0.001). Based on plasma voriconazole concentration measurement, an optimal voriconazole regimen (loading doses: 0.2 g twice daily; maintenance doses, 0.1 g once daily) was established, which resulted in rational trough plasma drug concentrations (1–5 μg/mL), good clinical outcomes (90-day survival rate of 6/8) and no observed adverse events. In conclusion, CLIF-SOFA lung score >1 was able to identify ACLF patients complicated with IPA encountering much higher 28-day mortality. An optimal voriconazole regimen was safe and effective in our ACLF patients complicated with IPA.
Broadband Asymmetric Light Transmission at Metal/Dielectric Composite Grating
Authors: Zhu Rui , Wu Xuannan , Hou Yidong , Zheng Gaige , Zhu Jianhua , Gao Fuhua
Published: January 2018

Optical diode-like effect has sparked growing interest in recent years due to its potential applications in integrated photonic systems. In this paper, we propose and numerically demonstrate a new type of easy-processing metal/dielectric cylinder composite grating on semi-sphere substrate, which can achieve high-contrast asymmetric transmission of unpolarized light for the sum of all diffraction modes in the entire visible region, and effectively guide the diffraction light transmitting out the substrate. The asymmetric light transmission (ALT) ratio is larger than 2 dB in the waveband from 380 nm to 780 nm and the maximum ALT ratio can reach to 13 dB at specified wavelengths. The thorough theoretical research reveals that the proposed metal/dielectric pillar composite grating structure, together with the substrate, can effectively excite localized surface plasmonic resonance (LSPR) effect and waveguide mode (WGM), and enlarge the diffraction difference between forward and backward transmission spaces, including both number of diffraction orders and diffraction efficiency, thus resulting in high-contrast broadband ALT phenomenon. In particular, lowering the symmetry of the grating can achieve polarization-dependent ALT. Such a type of easy-processing ALT device with high performance for both polarized and unpolarized light can be regarded as suitable candidates in practical applications.
Artificial Intelligence Estimation of Carotid-Femoral Pulse Wave Velocity using Carotid Waveform
Authors: Tavallali Peyman , Razavi Marianne , Pahlevan Niema M.
Published: January 2018

In this article, we offer an artificial intelligence method to estimate the carotid-femoral Pulse Wave Velocity (PWV) non-invasively from one uncalibrated carotid waveform measured by tonometry and few routine clinical variables. Since the signal processing inputs to this machine learning algorithm are sensor agnostic, the presented method can accompany any medical instrument that provides a calibrated or uncalibrated carotid pressure waveform. Our results show that, for an unseen hold back test set population in the age range of 20 to 69, our model can estimate PWV with a Root-Mean-Square Error (RMSE) of 1.12 m/sec compared to the reference method. The results convey the fact that this model is a reliable surrogate of PWV. Our study also showed that estimated PWV was significantly associated with an increased risk of CVDs.
Effects of silver nanocolloids on plant complex type N-glycans in Oryza sativa roots
Authors: Horiuchi Risa , Nakajima Yukari , Kashiwada Shosaku , Miyanishi Nobumitsu
Published: January 2018

Silver nanomaterials have been mainly developed as antibacterial healthcare products worldwide, because of their antibacterial activity. However, there is little data regarding the potential risks and effects of large amounts of silver nanomaterials on plants. In contrast, N-glycans play important roles in various biological phenomena, and their structures and expressions are sensitive to ambient environmental changes. Therefore, to assesse the effects of silver nanomaterials, we focused on the correlation between N-glycans and the effects of silver nanomaterials in plants and analyzed N-glycan structures in Oryza sativa seedlings exposed to silver nanocolloids (SNCs). The phenotype analysis showed that the shoot was not affected by any SNC concentrations, whereas the high SNC exposed root was seriously damaged. Therefore, we performed comparative N-glycan analysis of roots. As a result, five of total N-glycans were significantly increased in SNC exposed roots, of which one was a free-N-glycan with one beta-N-acetylglucosamine residue at the reducing end. Our results suggest that the transition of plant complex type N-glycans, including free-N-glycans, was caused by abnormalities in O. sativa development, and free-N-glycan itself has an important role in plant development. This study originally adapted glycome transition analysis to environmental toxicology and proposed a new category called “Environmental glycobiology”.
Cathelicidin-OA1, a novel antioxidant peptide identified from an amphibian, accelerates skin wound healing
Authors: Cao Xiaoqing , Wang Ying , Wu Chunyun , Li Xiaojie , Fu Zhe , Yang Meifeng , Bian Wenxin , Wang Siyuan , Song Yongli , Tang Jing , Yang Xinwang
Published: January 2018

Cathelicidins play pivotal roles in host defense. The discovery of novel cathelicidins is important research; however, despite the identification of many cathelicidins in vertebrates, few have been reported in amphibians. Here we identified a novel cathelicidin (named cathelicidin-OA1) from the skin of an amphibian species, Odorrana andersonii. Produced by posttranslational processing of a 198-residue prepropeptide, cathelicidin-OA1 presented an amino acid sequence of ‘IGRDPTWSHLAASCLKCIFDDLPKTHN′ and a molecular mass of 3038.5 Da. Functional analysis showed that, unlike other cathelicidins, cathelicidin-OA1 demonstrated no direct microbe-killing, acute toxicity and hemolytic activity, but did exhibit antioxidant activity. Importantly, cathelicidin-OA1 accelerated wound healing against human keratinocytes (HaCaT) and skin fibroblasts (HSF) in both time- and dose-dependent manners. Notably, cathelicidin-OA1 also showed wound-healing promotion in a mouse model with full-thickness skin wounds, accelerating re-epithelialization and granulation tissue formation by enhancing the recruitment of macrophages to the wound site, inducing HaCaT cell proliferation and HSF cell migration. This is the first cathelicidin identified from an amphibian that shows potent wound-healing activity. These results will help in the development of new types of wound-healing agents and in our understanding of the biological functions of cathelicidins.
Improved Linearity with Polarization Coulomb Field Scattering in AlGaN/GaN Heterostructure Field-Effect Transistors
Authors: Cui Peng , Lv Yuanjie , Liu Huan , Cheng Aijie , Fu Chen , Lin Zhaojun
Published: January 2018

The single-tone power of the AlGaN/GaN heterostructure field-effect transistors (HFETs) with different gate widths was measured. A distinct improvement in device linearity was observed in the sample with a larger gate width. The analysis of the variation of the parasitic source access resistance showed that, as the gate bias is increased, the polarization Coulomb field scattering can offset the increased polar optical phonon scattering and improve the device linearity. This approach is shown to be effective in improving the device linearity of AlGaN/GaN HFETs.
Organic semiconductor perylenetetracarboxylic diimide (PTCDI) electrodes for electrocatalytic reduction of oxygen to hydrogen peroxide
Authors: Warczak Magdalena , Gryszel Maciej , Jakešová Marie , Đerek Vedran , Głowacki Eric Daniel
Published: January 2018

Organic semiconductors can give high electrocatalytic currents while retaining excellent stability. We demonstrate the use of the industrial pigment PTCDI as a robust electrocatalyst for oxygen-to-peroxide electrolyzers operating at state-of-the-art efficiency.
Stepwise chelation-etching synthesis of carbon-confined ultrafine SnO2 nanoparticles for stable sodium storage
Authors: Zhang Yuanjie , Meng Jiashen , Wang Xuanpeng , Liu Xiong , Xu Xiaoming , Liu Ziang , Owusu Kwadwo Asare , Huang Congyun , Li Qi , Mai Liqiang
Published: January 2018

A stepwise chelation-etching strategy to synthesize ultrafine SnO2 nanoparticles with excellent sodium storage is developed.
Cocrystals of zileuton with enhanced physical stability
Authors: Chen Xin , Li Duanxiu , Luo Chun , Wang Jinqiu , Deng Zongwu , Zhang Hailu
Published: January 2018

Zileuton can form two promising pharmaceutical cocrystals with nicotinamide and isonicotinamide, which demonstrate superior phase stability against moisture.
Thep(O2)–Tstability domain of cubic perovskite Ba0.5Sr0.5Co0.8Fe0.2O3−δ
Authors: Yaremchenko Aleksey A. , Patrakeev Mikhail V. , Naumovich Eugene N. , Khalyavin Dmitry D.
Published: January 2018

The low-p(O2) and high-p(O2) stability boundaries of cubic perovskite BSCF at 700–950 °C correspond to a fixed value of the oxygen nonstoichiometry of 3 −δ= ∼2.13 and ∼2.515, respectively.
Kinetics of the a-C3H5+ O2reaction, investigated by photoionization using synchrotron radiation
Authors: Schleier D. , Constantinidis P. , Faßheber N. , Fischer I. , Friedrichs G. , Hemberger P. , Reusch E. , Sztáray B. , Voronova K.
Published: January 2018

The kinetics of the allyl + O2reaction has been studied in a flow tube reactor, using VUV synchrotron radiation for product detection.
Direct monitoring of spin transitions in a dinuclear triple-stranded helicate iron(ii) complex through X-ray photoelectron spectroscopy
Authors: Li Li , Craze Alexander R. , Akiyoshi Ryohei , Tsukiashi Asami , Hayami Shinya , Mustonen Outi , Bhadbhade Mohan M. , Bhattacharyya Saroj , Marjo Christopher E. , Wang Yun , Lindoy Leonard F. , Aldrich-Wright Janice R. , Li Feng
Published: January 2018

VT-XPS shows that the spin behaviour is reversible between the HS and LS states in a new dinuclear helicate iron(ii) complex.
First entry into nonmetal-centred porphycenes: synthesis of a phosphorus(v) complex of octaethylporphycene
Authors: Abe Masaaki , Mukotaka Hiroto , Fujioka Taro , Okawara Toru , Umegaki Kei , Ono Toshikazu , Hisaeda Yoshio
Published: January 2018

The first synthesis and structural characterization of a phosphorus(v) complex of porphycene, a constitutional isomer of porphyrin, are reported.
Step edge structures on the anatase TiO2(001) surface studied by atomic-resolution TEM and STM
Authors: Ek M. , Beinik I. , Bruix A. , Wendt S. , Lauritsen J. V. , Helveg S.
Published: January 2018

Atomic arrangements in oxide surfaces can be uncovered by combining side view imaging using transmission electron microscopy and top view imaging using scanning tunnelling microscopy.
A nano-catalytic approach for C–B bond formation reactions
Authors: Verma Piyush Kumar , Shegavi Mahadev L. , Bose Shubhankar Kumar , Geetharani K.
Published: January 2018

Nanoparticle-catalysed borylation is one of the most convenient methods for the synthesis of organoboranes to overcome the confines of homogeneous catalysis such as recyclability and heavy metal contamination.
Solvent incorporated sequential [3 + 2] annulation/substitution reaction of azomethine imines and propargyl sulfur ylide
Authors: Shen Shoujie , Yang Yanli , Duan Jiangyan , Jia Zhenhu , Liang Jinyan
Published: January 2018

A novel three-component, solvent incorporated sequential [3 + 2] cycloaddition/substitution reaction of azomethine imines with propargyl sulfur ylide was developed.
Implications of designing a bromelain loaded enteric nanoformulation on its stability and anti-inflammatory potential upon oral administration
Authors: Sharma Manu , Sharma Rishu
Published: January 2018

The objective of the present investigation was to develop an enteric nano-formulation of bromelain to improve its stability and anti-inflammatory potential.
Network structure of SnO2 hollow sphere/PANI nanocomposites for electrochemical performance
Authors: Wang Qianqian , Zong Quan , Zhang Chunlei , Yang Hui , Zhang Qilong
Published: January 2018

Homogeneous SnO2 hollow spheres have been synthesized through a hydrothermal method without a template, followed by in situ polymerization of PANI.
Evidence, Goals, and Outcomes in Stuttering Treatment: Applications With an Adolescent Who Stutters
Authors: Marcotte Anne K.
Published: January 2018

Purpose

The purpose of this clinical focus article is to summarize 1 possible process that a clinician might follow in designing and conducting a treatment program with John, a 14-year-old male individual who stutters.

Method

The available research evidence, practitioner experience, and consideration of individual preferences are combined to address goals, treatment procedures, and outcomes for John.

Conclusions

The stuttering treatment research literature includes multiple well-designed reviews and individual studies that have shown the effectiveness of prolonged speech (and smooth speech and related variations) for improving stuttered speech and for improving social, emotional, cognitive, and related variables in adolescents who stutter. Based on that evidence, and incorporating the additional elements of practitioner experience and client preferences, this clinical focus article suggests that John would be likely to benefit from a treatment program based on prolonged speech. The basic structure of 1 possible such program is also described, with an emphasis on the goals and outcomes that John could be expected to achieve.
MV bound and MV controller for convex‐non‐linear systems with input constraints
Authors: Alipouri Yousef , Huang Biao , Kodamana Hariprasad
Published: January 2018

To assess the performance of a control loop based on the minimum variance (MV) benchmark, we need to calculate MV lower bound (MVLB). Even though there is a plethora of literature available for calculating MVLB for the linear systems, these methods are not suitable for non‐linear systems. Furthermore, almost all of the real‐world applications have been encountered with input variance constraints. These constraints limit controllers' abilities in decreasing the output variability. Therefore, existing MVLB computation methods, which do not account for input constraints, are not realistic when applied to constrained systems. The authors propose a novel approach to estimate MVLB by employing properties of dual Lagrangian functions to address these issues simultaneously in this study. Furthermore, to design the constrained non‐linear MV controller (MVC), they propose to use the recurrent neural network for accommodating non‐linearities and the input constraints. Then, control loop stability, optimality with respect to MVLB as well as the global convergence of the proposed controller are analytically proved for convex‐non‐linear systems with input constraints. The proposed control strategy is verified through simulations performed on a non‐linear quadruple‐tank system. The results indicate that the proposed design provides satisfactory results in decreasing output variance while satisfying the constraints.
Transform‐based watermarking algorithm maintaining perceptual transparency
Authors: Shahdoosti Hamid Reza , Salehi Mohammad
Published: January 2018

Here, a novel, yet simple, transform‐based watermarking scheme for copyright protection has been proposed. The proposed method takes advantage of the rotation invariant property of the ripplet‐II transform which makes the proposed method robust against rotation attacks. In the proposed method, firstly a cost function of perceptual transparency is formed in the ripplet‐II domain. Secondly, the ridge regularisation constraint is added to the cost function to avoid the singularity problem in the model. In order to obtain the embedding weights, this function is minimised. Therefore, the embedding weights are adaptive to both the host image and watermark. Simulation results demonstrate that the proposed algorithm not only provides an excellent watermark invisibility, but it also shows superior robustness against common image processing operations and acceptable robustness against geometric distortions.
Sloshing in its cD halo: MUSE kinematics of the central galaxy NGC 3311 in the Hydra I cluster
Authors: Barbosa C. E. , Arnaboldi M. , Coccato L. , Gerhard O. , Mendes de Oliveira C. , Hilker M. , Richtler T.
Published: January 2018

Context.Early-type galaxies (ETGs) show a strong size evolution with redshift. This evolution is explained by fast “in-situ” star formation at high-zfollowed by a late mass assembly mostly driven by minor mergers that deposit stars primarily in the outer halo.

Aims.We aim to identify the main structural components of the Hydra I cD galaxy NGC 3311 to investigate the connection between the central galaxy and the surrounding stellar halo.

Methods.We produce maps of the line-of-sight velocity distribution (LOSVD) moments from a mosaic of MUSE pointings covering NGC 3311 out to 25 kpc. Combining deep photometric and spectroscopic data, we model the LOSVD maps using a finite mixture distribution, including four non-concentric components that are nearly isothermal spheroids, with different line-of-sight systemic velocitiesV, velocity dispersionsσ, and small (constant) values of the higher order Gauss-Hermite momentsh3andh4.

Results.The kinemetry analysis indicates that NGC 3311 is classified as a slow rotator, although the galaxy shows a line-of-sight velocity gradient along the photometric major axis. The comparison of the correlations betweenh3andh4withV/σwith simulated galaxies indicates that NGC 3311 assembled mainly through dry mergers. Theσprofile rises to ≃ 400 km s-1at 20 kpc, a significant fraction (0.55) of the Hydra I cluster velocity dispersion, indicating that stars there were stripped from progenitors orbiting in the cluster core. The finite mixture distribution modeling supports three inner components related to the central galaxy and a fourth component with large effective radius (51 kpc) and velocity dispersion (327 km s-1) consistent with a cD envelope. We find that the cD envelope is offset from the center of NGC 3311 both spatially (8.6 kpc) and in velocity (ΔV= 204 km s-1), but coincides with the cluster core X-ray isophotes and the mean velocity of core galaxies. Also, the envelope contributes to the broad wings of the LOSVD measured by largeh4values within 10 kpc.

Conclusions.The cD envelope of NGC 3311 is dynamically associated with the cluster core, which in Hydra I is in addition displaced from the cluster center, presumably due to a recent subcluster merger.
A new solution to the plasma starved event horizon magnetosphere
Authors: Punsly B. , Hardcastle M. , Hada K.
Published: January 2018

Very Long Baseline Interferometry observations at 86 GHz reveal an almost hollow jet in M87 with a forked morphology. The detailed analysis presented here indicates that the spectral luminosity of the central spine of the jet in M87 is a few percent of that of the surrounding hollow jet 200–400 μ as from the central black hole. Furthermore, recent jet models indicate that a hollow “tubular” jet can explain a wide range of plausible broadband spectra originating from jetted plasma located within ~30 μ as of the central black hole, including the 230 GHz correlated flux detected by the Event Horizon Telescope. Most importantly, these hollow jets from the inner accretion flow have an intrinsic power capable of energizing the global jet out to kiloparsec scales. Thus motivated, this paper considers new models of the event horizon magnetosphere (EHM) in low luminosity accretion systems. Contrary to some models, the spine is not an invisible powerful jet. It is an intrinsically weak jet. In the new EHM solution, the accreted poloidal magnetic flux is weak and the background photon field is weak. It is shown how this accretion scenario naturally results in the dissipation of the accreted poloidal magnetic flux in the EHM not the accumulation of poloidal flux required for a powerful jet. The new solution indicates less large scale poloidal magnetic flux (and jet power) in the EHM than in the surrounding accretion flow and cannot support significant EHM driven jets.
Second-Generation Azafullerene Monoadducts as Electron Acceptors in Bulk Heterojunction Solar Cells
Authors: Marsal Lluis , von Delius Max , Bothe Michael , Montero-Rama María , Viterisi Aurélien , Cambarau Werther , Stenta Caterina , Palomares Emilio
Published: January 2018

Four new azafullerene monoadducts (DPS-C59N, HDP-C59N, DBOP-C59N, DHOP-C59N) have been prepared and applied as electron acceptors in solution-processed bulk heterojunction solar cells. The four compounds were designed so that their solubility in organic solvents was maximized and that structure–property comparisons could be drawn with a previously synthesized azafullerene electron acceptor. With the photovoltaic devices that were prepared from the four aza­fullerenes and polymeric electron donor PTB7 we found that only one of the four new electron acceptors resulted in a power conversion efficiency that exceeded the one observed with a previously reported aza­fullerene monoadduct. Atomic force microscopy and electron mobility measurements suggest that azafullerenes bearing two alkyl chains lead to non-optimal film morphologies as well as electron mobilities and that future efforts should focus on single n-alkyl substitution.
Validation of the Modified Surgeon Periorbital Rating of Edema and Ecchymosis (SPREE) Questionnaire: A Prospective Analysis of Facial Plastic and Reconstructive Surgery Procedures
Authors: Oliver Jeremie , Menapace Deanna , Younes Ahmed , Recker Chelsey , Hamilton Grant , Friedman Oren
Published: January 2018

Although periorbital edema and ecchymosis are commonly encountered after facial plastic and reconstructive surgery procedures, there is currently no validated grading scale to qualify these findings. In this study, the modified “Surgeon Periorbital Rating of Edema and Ecchymosis (SPREE)” questionnaire is used as a grading scale for patients undergoing facial plastic surgery procedures. This article aims to validate a uniform grading scale for periorbital edema and ecchymosis using the modified SPREE questionnaire in the postoperative period. This is a prospective study including 82 patients at two different routine postoperative visits (second and seventh postoperative days), wherein the staff and resident physicians, physician assistants (PAs), patients, and any accompanying adults were asked to use the modified SPREE questionnaire to score edema and ecchymosis of each eye of the patient who had undergone a plastic surgery procedure. Interrater and intrarater agreements were then examined. Cohen's kappa coefficient was calculated to measure intrarater and interrater agreement between health care professionals (staff physicians and resident physicians); staff physicians and PAs; and staff physicians, patients, and accompanying adults. Good to excellent agreement was identified between staff physicians and resident physicians as well as between staff physicians and PAs. There was, however, poor agreement between staff physicians, patients, and accompanying adults. In addition, excellent agreement was found for intraobserver reliability during same-day visits. The modified SPREE questionnaire is a validated grading system for use by health care professionals to reliably rate periorbital edema and ecchymosis in the postoperative period. Validation of the modified SPREE questionnaire may improve ubiquity in medical literature reporting and related outcomes reporting in future.
Extrusão do cateter peritoneal pela vagina. Complicação rara de derivação ventriculoperitoneal
Authors: Pereira Carlos Umberto , Silva Alvino Dutra da , Vieira Gonzaga Ana Karina , Santos Janicelma dos
Published: January 2018

A migração do cateter peritoneal pela vagina é uma condição rara após derivação ventriculoperitoneal. Os autores descrevem um caso de extrusão do cateter peritoneal pela vagina, em uma criança de seis meses de idade, com boa evolução e discutem sua provável causa.
Malformação arteriovenosa dural do seio transverso-sigmóide causando neuralgia trigeminal
Authors: de Paula Lucas César , da Costa Válter , da Costa Joaquim , Martins Luís Fernando , Melo-Souza Sebastião E. , Raffin César N.
Published: January 2018

Os autores relatam um caso raro de malformação arteriovenosa dural (MAVD) do seio transverso-sigmóide esquerdo, causando neuralgia do trigêmeo. O paciente foi submetido a cirurgia para esqueletização do seio transverso-sigmóide com ressecção dos dois terços distais do seio transverso e dos dois terços proximais do seio sigmóide. O procedimento cirúrgico foi suficiente para proporcionar a cura angiográfica e clínica, com um seguimento de oito meses. Foi realizada uma completa revisão bibliográfica encontrando-se apenas cinco casos descritos de pacientes com MAVD e neuralgia trigeminal.
Abscesso epidural raquiano: Análise de 15 casos
Authors: Pereira Celestino Esteves , Lynch José Carlos
Published: January 2018

Quinze pacientes com abscesso epidural raquiano foram tratados entre janeiro de 1986 e janeiro de 1996. Dez eram homens e 5, mulheres, com idade mediana de 50 anos. A associação de patologias que levam à imunodepressão, como diabetes e infecções, ocorreu em 67% dos casos. Todos os pacientes tinham dor na coluna vertebral, 11 apresentavam fraqueza muscular, 6 tinham parestesias e 5, alterações esfincterianas.

Dezesseis procedimentos cirúrgicos foram realizados nos 15 pacientes. Em 6 casos, o abscesso continha material francamente purulento; em 3, a coleção epidural apresentava-se como tecido de granulação e, em outros 4 casos, ambos estavam presentes. O Staphylococcus aureus foi isolado em 53% dos abscessos, e o bacilo da tuberculose em 20%. A coluna lombar foi comprometida em 8 casos e a cervical em 3.

O tratamento de escolha consiste na imediata drenagem cirúrgica do abscesso antes do desenvolvimento de déficit neurológico grave, combinado com antibioticoterapia específica.

Onze pacientes recuperaram suas funções neurológicas normais, e 4 permaneceram com alguma seqüela. Nesta série não ocorreu óbito.
Macroadenomas hipofisários: Análise da ressonância magnética pré e pós-operatória em 20 casos
Authors: Leme Ricardo José de Almeida , Seng Shu Edson Bor , Machado José Jorge , Magalhães Álvaro Cebrian , Marino Raul
Published: January 2018

Foram realizadas ressonâncias magnéticas (RM) pré e pós-operatórias em 20 pacientes com macroadenomas hipofisários (diâmetro variando entre 1,1 cm e 4,5 cm), que foram avaliados quanto aos achados normais (fisiológicos) e anormais, após a cirurgia transesfenoidal. As imagens foram obtidas a partir de aparelhos de 1,5 tesla, com cortes sagitais e coronais, antes e após a injeção de contraste paramagnético (gadopentato de dimeglumina).

As alterações fisiológicas encontradas após a cirurgia incluíram o material hemostático implantado ainda não reabsorvido, opacificações do seio esfenoidal, reexpansão da glândula hipofisária e rebaixamento do quiasma óptico. O gelfoam implantado apareceu como imagem intra-selar, circular, com realce de contraste na periferia que, em estudos posteriores, diminuiu de tamanho. Os implantes de músculo e gordura apareceram como áreas de hipersinal, sendo o sinal do músculo menos intenso que o da gordura. Os tumores residuais foram diferenciados dos materiais implantados pela sua localização, características da intensidade do sinal e padrão de realce.

Os estudos pré-operatórios e as informações clínicas são de grande valia na avaliação pós-operatória da RM. Os exames de RM de controle, nos casos estudados, mostrou que o momento ideal para a realização desse controle é após o período de quatro a seis meses, uma vez que exames realizados antes desse período não permitiram a diferenciação entre materiais implantados e tumores residuais.
Dor facial atípica: caracterização de uma amostra
Authors: Teixeira Manoel Jacobsen , Seng Shu Edson Bor , Nóbrega José Cláudio Marinho da , Corrêa Cláudio Fernandes
Published: January 2018

As características funcionais e morfológicas da face, aliadas à complexidade do fenômeno doloroso, tornam a face favorável à existência de inúmeras fontes de dor como procuram demonstrar as várias classificações existentes a respeito.

No período de janeiro de 1986 a março de 1993, 57 doentes com dor facial de etiologia incerta foram submetidos a avaliações neurológica, bucomaxilofacial, psiquiátrica, psicológica e de medicina física. Foram também investigados, por procedimentos de imagem do crânio, coluna cervical e exames de laboratório, incluindo o do líquido cefalorraquidiano. A idade média dos doentes foi 51 anos. Trinta e nove doentes (68%) eram do sexo feminino. O tempo de história da dor variou de 1 mês a 23 anos, com média de 61,8 meses. A dor em queimação foi a mais freqüente (43%) seguida de latejante (33%). A hemiface direita foi acometida em 27 doentes (47,3%) e 8 doentes (14,2%) tiveram comprometimento bilateral. Quanto à distribuição topográfica de acometimento houve predomínio em V2, com 17 doentes (29,8%); a hemiface inteira foi comprometida em 10 doentes (17,5%). Irradiação para locais não correspondentes ao território de inervação do nervo trigêmeo observou-se em 15 doentes (26,3%), sendo em 5 (33,3%) para a região cervical, em 5 (33%) para o ouvido, em 2 (13,3%) irradiou para a região occipital e em outros 2 para a nuca. A dor teve freqüência diária em 43 doentes (75,4%). A duração da dor tomava a maior parte do dia em todos os doentes.

Fatores moduladores de melhora ou piora da dor facial atípica foram encontrados em 27 doentes (47,3%); desses, 4 (14,8%) referiram melhora da dor com pressão ou calor local e 23 (85%) referiram fatores de piora da dor, sendo o nervosismo e o frio os principais fatores relatados, respectivamente, por 10 (17,6%) e 8 (14%) dos doentes. Dois (3,5%) pacientes pioraram com o calor. Fenômenos neurovegetativos não foram raros, acometendo 20 doentes (35%). Sintomas neuropsíquicos, depressão e/ou ansiedade foram encontrados em 28 (49,1%) doentes. A síndrome dolorosa miofascial esteve associada em 18 (31,5%) doentes. Vinte e um doentes (36,8%) tiveram antecedentes de trauma ou cirurgia da face. Alterações no exame físico foram observadas em 13 (22,8%) doentes, sendo 11 (19,3%) doentes com hipoestesia facial.

A investigação diagnóstica dos 57 pacientes com padrão de dor facial atípica confirmou 45 casos de dor facial atípica. Em 12, outros diagnósticos foram encontrados.

O diagnóstico de dor facial atípica é de exclusão e a avaliação multiprofissional é essencial.
Traumatismo craniencefálico por acidente com bicicleta: Resultados preliminares
Authors: Pereira Carlos Umberto , Abud Lauro do Nascimento , Abud Fábio do Nascimento , Leite Roberta Teixeira
Published: January 2018

A principal causa de traumatismo craniencefálico tem sido os acidentes de trânsito, acometendo mais os adultos jovens do sexo masculino. O traumatismo craniencefálico decorrente de queda de bicicleta é freqüente e provoca lesões neurológicas graves. Em nosso meio, o uso de capacete não tem sido obrigatório para ciclistas, aumentando o número de ciclistas com lesões cerebrais. Os autores apresentam a experiência no atendimento de vítimas de traumatismo craniencefálico por queda de bicicleta.
Meningite conseqüente a macroadenoma hipofisário: Relato de caso
Authors: Barros Raul Starling de , Ulrich Katleen Cotti , Delfino Ricardo Augusto
Published: January 2018

Os autores relatam um caso de macroprolactinoma que evoluiu com meningite e pneumoencéfalo espontâneo. Discutem-se os possíveis mecanismos dessa evolução.
Nucleotratotomia trigeminal estereotáxica no tratamento da dor facial atípica
Authors: da Nóbrega José Cláudio Marinho , Teixeira Manoel Jacobsen , Corrêa Cláudio Fernandes , Okada Massako
Published: January 2018

As características funcionais e morfológicas da face, aliadas à complexidade do fenômeno doloroso, tornam favorável a existência de inúmeras fontes de dor facial, como procuraram demonstrar as várias classificações existentes a respeito. A nucleotratotomia trigeminal consiste na ablação cirúrgica de núcleos trigeminais de segunda ordem e tratos.

Dois casos de dor facial atípica refratários ao tratamento medicamentoso ou a outras formas nãooperatórias são discutidos. A intensidade da dor pré e pós-operatória foi avaliada pela Escala Visual Analógica. A técnica operatória é descrita.

Os resultados imediatos foram satisfatórios em ambos os casos. Um doente teve recidiva da dor, com menor intensidade, dois meses após o procedimento e o outro estava assintomático oito meses depois. Um doente apresentou ataxia transitória que regrediu em dois meses; o outro teve meningite bacteriana no pós-operatório. Aspectos terapêuticos e as bases fisiopatológicas da indicação cirúrgica são apresentados.
Hemangioma cavernoso do nervo óptico: Relato de caso
Authors: Araújo João Flávio de Mattos , de Tella Oswaldo Inácio , Cardoso Santos Marcos Vinicius , Sperlescu Alexander
Published: January 2018

Os autores apresentam um caso em que um angioma cavernoso, envolvendo o nervo óptico, comprometeu progressivamente a visão direita de um paciente do sexo masculino, de 29 anos de idade. O paciente foi operado e o anatomopatológico comprovou o diagnóstico. É feita a revisão da literatura, em que 18 casos foram previamente relatados, existindo o risco de hemorragia, acarretando a apoplexia quiasmática. A importância da ressonância magnética para o diagnóstico é confirmada. O diagnóstico precoce e a total remoção da lesão são o tratamento de escolha para essa lesão.
Abscesso cerebral associado à cardiopatia congênita cianótica: Considerações sobre 17 casos
Authors: Pereira Carlos Umberto , da Silva Alvino Dutra , Carneiro Leão João Domingos Barbosa , Moura Sotero André Luiz , Costa Araújo Caroline de Souza , Santos Porto Clarissa Pereira
Published: January 2018

Abscesso cerebral associado a cardiopatia congênita cianótica não tem sido uma patologia comum na prática clínica. Foi feita extensa revisão bibliográfica sobre o tema e a casuística própria é apresentada. No período entre janeiro de 1992 e julho de 2000 foram internados 17 casos de abscesso cerebral associado à cardiopatia congênita cianótica no Serviço de Neurocirurgia do Hospital João Alves Filho e da Fundação Beneficente Hospital de Cirurgia (Aracaju, SE). Foram analisados quanto a sexo, idade, patologia cardíaca, microrganismos encontrados, localização do abscesso, quadro clínico, exames complementares, tratamento e prognóstico.

Não houve predominância do sexo e a média etária foi de 6,5 anos. A cardiopatia congênita mais comum foi tetralogia de Fallot (76,5%), seguida da atresia tricúspide (11,7%), trilogia de Fallot (5,9%) e persistência do ducto arteriosus (5,9%). As sintomatologias predominantes foram febre (70,6%), cefaléia (53%), hemiparesia (47%), crise convulsiva (47%), náuseas e vômitos (35,3%) e papiledema (35,3%). A localização do abscesso predominou no lobo parietal (47,1%), seguido do lobo frontal (23,6%), frontoparietal (11,7%), temporoparietal (11,7%); abscessos múltiplos foram observados em um caso (5,9%). O tratamento cirúrgico foi realizado em 14 pacientes e o conservador, em três. Óbito ocorreu em quatro casos (23,5%.): em três devido a sepse e, em um, ao edema cerebral.
Abscesso epidural raquiano piogênico: Relato de três casos em adolescentes
Authors: Tavares de Lima Frederico de Melo , da Silva Joacil Carlos
Published: January 2018

O acometimento bacteriano não tuberculoso do espaço epidural raquiano é raro nas primeiras décadas de vida. Apesar do aparente aumento na incidência constatado nas casuísticas modernas, a descrição dessa entidade patológica em nosso meio permanece esporádica.

Os autores apresentam três casos em adolescentes com idade média de 13,6 anos. As peculiaridades da apresentação clínica e do manejo terapêutico ideal são discutidas. Ressaltam que um elevado grau de suspeição clínica deve ser mantido para evitar um retardo no diagnóstico desses pacientes.
Prevenção de hematoma subgaleal pós-operatório. Técnica de curativo
Authors: Lopes Pedro Garcia , Alves Alessandro Almeida , da Silva Dael Moia , Rocha Lobo Bruno Carmelo , Lehmann Márcio Francisco
Published: January 2018

Uma das complicações que ocorrem no pós-operatório das craniotomias é a formação de coleções subgaleais por extravasamento de sangue ao nível da incisão. Apesar da utilização de curativos compressivos, esses fatos ocorrem em grande número de casos e, em alguns serviços, são utilizados drenos externos para tentar minimizar esse problema. Como, além de onerar o procedimento cirúrgico, essa técnica ainda possibilita o aparecimento de infecção, o Serviço de Neurocirurgia do Hospital Universitário do Norte do Paraná passou a utilizar uma nova técnica de curativo, em que são utilizadas luva e dreno de Penrose parcialmente cheios de soro, respectivamente sobre a craniotomia e na região supra-orbitária, conseguindo evitar essa complicação.
Benefícios da hemisferectomia em pacientes com hemimegalencefalia
Authors: Lessa Zambelli Helder José , Facure José Jorge , Rocco Concezio Di , Iannelli Aldo , Honorato Donizeti Cesar
Published: January 2018

A hemisferectomia é realizada em muitos casos de hemimegalencefalia para controlar a epilepsia refratária ao tratamento medicamentoso. No entanto, apesar de haver concordância sobre a efetividade desse procedimento para controle das crises, a escolha da técnica cirúrgica utilizada ainda é motivo de debate.

Relatamos os casos de três crianças com hemimegalencefalia submetidas à hemisferectomia para tratamento de suas crises refratárias: uma foi submetida à hemisferectomia anatômica e as outras duas, à hemisferectomia funcional.

Os resultados confirmam a efetividade da hemisferectomia para o controle das crises epilépticas nesses casos.
Remoção do cisto sinovial da articulação atlantoaxial pela via póstero-lateral transdural
Authors: Macedo Bianco André de , Madeira Lucas , Fortini Ida , Reis Elias Alexandre José , Shibata Milton K.
Published: January 2018

Mielopatia cervical alta causada por cisto sinovial da articulação atlantoaxial é uma entidade rara e muito pouco descrita na literatura. Os autores descreveram um caso de cisto sinovial localizado posteriormente ao processo odontóide causando compressão bulbo-medular em paciente com 88 anos de idade. O cisto foi removido através de um acesso póstero-lateral direito com hemilaminectomia de C1 e ressecção microcirúrgica transdural. A paciente apresentou uma excelente recuperação. Os aspectos etiológicos e terapêuticos são discutidos.
Tratamento conservador da síndrome do túnel do carpo: Revisão da literatura
Authors: Pereira Carlos Umberto , de Carvalho Alex Franco , de Carvalho Max Franco , do Nascimento Thiago Francisco
Published: January 2018

A síndrome do túnel do carpo (STC) é a neuropatia compressiva mais prevalente na população. Seu tratamento ainda é controverso, particularmente no que se refere à eficácia do tratamento conservador. Os autores revisam importantes trabalhos sobre o tratamento não operatório da STC e sugerem esquemas de tratamento de acordo com a severidade dos sintomas.
Diabetes insípido pós-traumático: Relato de caso
Authors: Pereira Carlos Umberto , Silva Alcântara Marta Regina , Silva Santos Egmond Alves , Fontes Santos Pâmera Cristal , Lima Meyline Andrade
Published: January 2018

Diabetes insípido é uma síndrome caracterizada por poliúria e polidipsia. Existem várias causas para o seu desenvolvimento. O traumatismo craniencefálico corresponde à cerca de 3% das causas de diabetes insípido central. Os autores relatam o caso de um paciente com 27 anos de idade, politraumatizado, que desenvolveu diabetes insípido dois dias após o trauma. Discutem a fisiopatologia, diagnóstico, tratamento e fazem uma revisão da literatura médica.
Primeiro estudo cooperativo em neurotraumatologia: Experiência inicial e ações futuras
Authors: Andrade Almir F. , Maset Angelo L. , Valêncio Carlos Roberto , Saade Nelson , Suriano Ítalo C. , Listik Sérgio , Monteiro Ruy , Aguiar Luiz R. , Melo Carlos Vinícius M. , Parisi de Oliveira Carlos T. , Mello Luis R. , Paranhos Jorge , Fiorillo Flávio , Veiga José Carlos
Published: January 2018

Este projeto é trabalho do Departamento de Trauma da Sociedade Brasileira de Neurocirurgia, realizado com a colaboração de diversas instituições, com o objetivo de conceber uma infra-estrutura que permita estudos prospectivos (multicêntricos ou não) de questões relacionadas à neurotraumatologia, coletando dados via Internet entre instituições. Descrevemos a situação atual do “Projeto Diretrizes de Atendimento ao Traumatismo Craniencefálico”. Apresentamos os resultados iniciais de um estudo cooperativo entre diversas instituições médicas através da criação de um banco de dados e estabelecemos um novo protocolo de estudo. Propomos que o sistema atual evolua à semelhança do BrainIT Group. No momento é uma proposta conceitual, de uma estrutura de coordenação entre serviços e de acesso a bancos de dados e que estabeleça critérios para publicação.
Astrocitomas: Uma revisão abrangente
Authors: Girão Faria Mário Henrique , Vidal do Patrocínio Régia Maria do Socorro , Barem Rabenhorst Silvia Helena
Published: January 2018

A presente revisão aborda os atuais conceitos sobre a origem celular, a etiologia, a classificação e a graduação dos astrocitomas. Os achados neuropatológicos característicos dos diferentes tipos de neoplasias astrocíticas são apresentados de acordo com o sistema adotado pela Organização Mundial da Saúde. Além disso, relata-se o presente estado da arte acerca da genética molecular desses tumores. Após descrever o perfil epidemiológico e os aspectos clínicos gerais, a situação atual do tratamento multidisciplinar e as novas perspectivas terapêuticas para os astrocitomas são comentadas.