bluuebunny/crossref_metadata_2025 huggingface dataset:
Regulation of FcRγ function by site-specific serine phosphorylation
Authors: Shah Spandan , Gibson Andrew W , Ji Chuanyi , Darrington Eric , Mobley James , Kojima Kyoko , Edberg Jeffrey C , Kimberly Robert P
Published: September 2016

The common FcRγ, an immunoreceptor tyrosine-based activation motif (ITAM)- containing adaptor protein, associates with multiple leukocyte receptor complexes and mediates signal transduction through the ITAM in the cytoplasmic domain. The presence of multiple serine and threonine residues within this motif suggests the potential for serine/threonine phosphorylation in modulating signaling events. Single-site mutational analysis of these residues in RBL-2H3 cells indicates that each may contribute to net FcRγ-mediated signaling, and mass spectrometry of WT human FcRγ from receptor-stimulated cells shows consistent preferential phosphorylation of the serine residue at position 51. Immunoblot analysis, mass spectrometry, and mutational analyses showed that phosphorylation of serine 51 in the 7-residue spacer between the 2 YxxL sequences regulates FcRγ signaling by inhibiting tyrosine phosphorylation at the membrane proximal Y47 position of the ITAM, but not phosphorylation at position Y58. This inhibition results in reduced Syk recruitment and activation. With in vitro kinase assays, PKC-δ and PKA show preferential phosphorylation of S51. Serine/threonine phosphorylation of the FcRγ ITAM, which functions as an integrator of multiple signaling elements, may explain in part the contribution of variants in PKC-δ and other PKC isoforms to some autoimmune phenotypes.
Lipoxin A4, a 5-lipoxygenase pathway metabolite, modulates immune response during acute respiratory tularemia
Authors: Singh Anju , Rahman Tabassum , Bartiss Rose , Arabshahi Alireza , Prasain Jeevan , Barnes Stephen , Musteata Florin Marcel , Sellati Timothy J
Published: September 2016

Respiratory infection with Francisella tularensis (Ft) is characterized by a muted, acute host response, followed by sepsis-like syndrome that results in death. Infection with Ft establishes a principally anti-inflammatory environment that subverts host-cell death programs to facilitate pathogen replication. Although the role of cytokines has been explored extensively, the role of eicosanoids in tularemia pathogenesis is not fully understood. Given that lipoxin A4 (LXA4) has anti-inflammatory properties, we investigated whether this lipid mediator affects host responses manifested early during infection. The addition of exogenous LXA4 inhibits PGE2 release by Ft-infected murine monocytes in vitro and diminishes apoptotic cell death. Tularemia pathogenesis was characterized in 5-lipoxygenase-deficient (Alox5−/−) mice that are incapable of generating LXA4. Increased release of proinflammatory cytokines and chemokines, as well as increased apoptosis, was observed in Alox5−/− mice as compared with their wild-type counterparts. Alox5−/− mice also exhibited elevated recruitment of neutrophils during the early phase of infection and increased resistance to lethal challenge. Conversely, administration of exogenous LXA4 to Alox5−/− mice made them more susceptible to infection thus mimicking wild-type animals. Taken together, our results suggest that 5-LO activity is a critical regulator of immunopathology observed during the acute phase of respiratory tularemia, regulating bacterial burden and neutrophil recruitment and production of proinflammatory modulators and increasing morbidity and mortality. These studies identify a detrimental role for the 5-LO–derived lipid mediator LXA4 in Ft-induced immunopathology. Targeting this pathway may have therapeutic benefit as an adjunct to treatment with antibiotics and conventional antimicrobial peptides, which often have limited efficacy against intracellular bacteria.
Wavefield compression for adjoint methods in full-waveform inversion
Authors: Boehm Christian , Hanzich Mauricio , de la Puente Josep , Fichtner Andreas
Published: September 2016

Adjoint methods are a key ingredient of gradient-based full-waveform inversion schemes. While being conceptually elegant, they face the challenge of massive memory requirements caused by the opposite time directions of forward and adjoint simulations and the necessity to access both wavefields simultaneously for the computation of the sensitivity kernel. To overcome this bottleneck, we have developed lossy compression techniques that significantly reduce the memory requirements with only a small computational overhead. Our approach is tailored to adjoint methods and uses the fact that the computation of a sufficiently accurate sensitivity kernel does not require the fully resolved forward wavefield. The collection of methods comprises reinterpolation with a coarse temporal grid as well as adaptively chosen polynomial degree and floating-point precision to represent spatial snapshots of the forward wavefield on hierarchical grids. Furthermore, the first arrivals of adjoint waves are used to identify “shadow zones” that do not contribute to the sensitivity kernel. Numerical experiments show the high potential of this approach achieving an effective compression factor of three orders of magnitude with only a minor reduction in the rate of convergence. Moreover, it is computationally cheap and straightforward to integrate in finite-element wave propagation codes with possible extensions to finite-difference methods.
On microscale heterogeneity in granular media and its impact on elastic property estimation
Authors: Sain Ratnanabha , Mukerji Tapan , Mavko Gary
Published: September 2016

We emphasize the existence of stress-dependent microscopic heterogeneities in granular media and their influence on macroscopic property estimation using numerical simulations. Although numerical simulations based on contact mechanics successfully reproduce experimental stress-dependent acoustic response of granular media, most contact-mechanics-based effective medium theories (EMTs) fail. We have determined that the main reason for this discrepancy is an inadequate theoretical treatment of micro-heterogeneities in structure, force, and stress. Under infinitesimal perturbations used for estimating elastic moduli, microheterogeneities lead to displacements or relaxations — typically ignored in EMT. These infinitesimal granular relaxations are necessary to comply with detailed force balance, but do not involve grain slip and hence do not depend on friction. Furthermore, we have found that these relaxations primarily depend on the “amount” of heterogeneity, which to a first order are dependent on stress only and are independent of mineralogy. In the absence of an effective medium framework to estimate such relaxation corrections, we have provided simulation-based corrections to account for the impact of heterogeneity on elastic moduli calculations in EMT.
Caenorhabditis elegansglutamylating enzymes function redundantly in male mating
Authors: Chawla Daniel G. , Shah Ruchi V. , Barth Zachary K. , Lee Jessica D. , Badecker Katherine E. , Naik Anar , Brewster Megan M. , Salmon Timothy P. , Peel Nina
Published: September 2016

Microtubule glutamylation is an important modulator of microtubule function and has been implicated in the regulation of centriole stability, neuronal outgrowth and cilia motility. Glutamylation of the microtubules is catalyzed by a family of tubulin tyrosine ligase-like (TTLL) enzymes. Analysis of individual TTLL enzymes has led to an understanding of their specific functions, but how activities of the TTLL enzymes are coordinated to spatially and temporally regulate glutamylation remains relatively unexplored. We have undertaken an analysis of the glutamylating TTLL enzymes in C. elegans. We find that although all five TTLL enzymes are expressed in the embryo and adult worm, loss of individual enzymes does not perturb microtubule function in embryonic cell divisions. Moreover, normal dye-filling, osmotic avoidance and male mating behavior indicate the presence of functional amphid cilia and male-specific neurons. A ttll-4(tm3310); ttll-11(tm4059); ttll-5(tm3360) triple mutant, however, shows reduced male mating efficiency due to a defect in the response step, suggesting that these three enzymes function redundantly, and that glutamylation is required for proper function of the male-specific neurons.
How great white sharks nourish their embryos to a large size: evidence of lipid histotrophy in lamnoid shark reproduction
Authors: Sato Keiichi , Nakamura Masaru , Tomita Taketeru , Toda Minoru , Miyamoto Kei , Nozu Ryo
Published: September 2016

The great white shark (Carcharodon carcharias) exhibits viviparous and oophagous reproduction. A 4950 mm total length (TL) gravid female accidentally caught by fishermen in the Okinawa Prefecture, Southern Japan carried six embryos (543-624 mm TL, three in each uterus). Both uteri contained copious amounts of yellowish viscous uterine fluid (over 79.2 litres in the left uterus), nutrient eggs and broken egg cases. The embryos had yolk stomachs that had ruptured, the mean volume of which was approximately 197.9 ml. Embryos had about 20 rows of potentially functional teeth in the upper and lower jaws. Periodic acid Schiff (PAS)-positive substances were observed on the surface and in the cytoplasm of the epithelial cells, and large, secretory, OsO4-oxidized lipid droplets of various sizes were distributed on the surface of the villous string epithelium on the uterine wall. Histological examination of the uterine wall showed it to consist of villi, similar to the trophonemata of Dasyatidae rays, suggesting that the large amount of fluid found in the uterus of the white shark was likely required for embryo nutrition. We conclude that: (1) the lipid-rich fluid is secreted from the uterine epithelium only in early gestation before the onset of oophagy, (2) the embryos probably use the abundant uterine fluid and encased nutrient eggs for nutrition at this stage of their development, and (3) the uterine fluid is the major source of embryonic nutrition before oophagy onset. This is the first record of the lipid histotrophy of reproduction among all shark species.
Amontillado is required forDrosophilaSlit processing and for tendon-mediated muscle patterning
Authors: Ordan Elly , Volk Talila
Published: September 2016

Slit cleavage into N-terminal and C-terminal polypeptides is essential for restricting the range of Slit activity. Although the Slit cleavage site has been characterized previously and is evolutionally conserved, the identity of the protease that cleaves Slit remains elusive. Our previous analysis indicated that Slit cleavage is essential to immobilize the active Slit-N at the tendon cell surfaces, mediating the arrest of muscle elongation. In an attempt to identify the protease required for Slit cleavage we performed an RNAi-based assay in the ectoderm and followed the process of elongation of the lateral transverse muscles toward tendon cells. The screen led to the identification of the Drosophila homolog of pheromone convertase 2 (PC2), Amontillado (Amon), as an essential protease for Slit cleavage. Further analysis indicated that Slit mobility on SDS polyacrylamide gel electrophoresis (SDS-PAGE) is slightly up-shifted in amon mutants, and its conventional cleavage into the Slit-N and Slit-C polypeptides is attenuated. Consistent with the requirement for amon to promote Slit cleavage and membrane immobilization of Slit-N, the muscle phenotype of amon mutant embryos was rescued by co-expressing a membrane-bound form of full-length Slit lacking the cleavage site and knocked into the slit locus. The identification of a novel protease component essential for Slit processing may represent an additional regulatory step in the Slit signaling pathway.
Rabbit Achilles tendon full transection model – wound healing, adhesion formation and biomechanics at 3, 6 and 12 weeks post-surgery
Authors: Meier Bürgisser Gabriella , Calcagni Maurizio , Bachmann Elias , Fessel Gion , Snedeker Jess G. , Giovanoli Pietro , Buschmann Johanna
Published: September 2016

After tendon rupture repair, two main problems may occur: re-rupture and adhesion formation. Suitable non-murine animal models are needed to study the healing tendon in terms of biomechanical properties and extent of adhesion formation. In this study 24 New Zealand White rabbits received a full transection of the Achilles tendon 2 cm above the calcaneus, sutured with a 4-strand Becker suture. Post-surgical analysis was performed at 3, 6 and 12 weeks. In the 6-week group, animals received a cast either in a 180 deg stretched position during 6 weeks (adhesion provoking immobilization), or were re-casted with a 150 deg position after 3 weeks (adhesion inhibiting immobilization), while in the other groups (3 and 12 weeks) a 180 deg position cast was applied for 3 weeks. Adhesion extent was analyzed by histology and ultrasound. Histopathological scoring was performed according to a method by Stoll et al. (2011), and the main biomechanical properties were assessed. Histopathological scores increased as a function of time, but did not reach values of healthy tendons after 12 weeks (only around 15 out of 20 points). Adhesion provoking immobilization led to an adhesion extent of 82.7±9.7%, while adhesion inhibiting immobilization led to 31.9±9.8% after 6 weeks. Biomechanical properties increased over time, however, they did not reach full strength nor elastic modulus at 12 weeks post-operation. Furthermore, the rabbit Achilles tendon model can be modulated in terms of adhesion formation to the surrounding tissue. It clearly shows the different healing stages in terms of histopathology and offers a suitable model regarding biomechanics because it exhibits similar biomechanics as the human flexor tendons of the hand.
Cancer metabolism at a glance
Authors: Vazquez Alexei , Kamphorst Jurre J. , Markert Elke K. , Schug Zachary T. , Tardito Saverio , Gottlieb Eyal
Published: September 2016

A defining hallmark of cancer is uncontrolled cell proliferation. This is initiated once cells have accumulated alterations in signaling pathways that control metabolism and proliferation, wherein the metabolic alterations provide the energetic and anabolic demands of enhanced cell proliferation. How these metabolic requirements are satisfied depends, in part, on the tumor microenvironment, which determines the availability of nutrients and oxygen. In this Cell Science at a Glance paper and the accompanying poster, we summarize our current understanding of cancer metabolism, emphasizing pathways of nutrient utilization and metabolism that either appear or have been proven essential for cancer cells. We also review how this knowledge has contributed to the development of anticancer therapies that target cancer metabolism.
CULTURAL SPACES FORMED BY THE DESCENDANTS OF THE EASTERN SLAVS ON THE TERRITORY OF CENTRAL PART OF RUSSIA AS THE INTANGIBLE CULTURAL HERITAGE AND TOURIST ATTRACTIONS
Authors: Харитонова Татьяна , Kharitonova Tatyana
Published: September 2016

Currently, many states face the threat to lose the national identity, and all progressive mankind should be worried about it. Therefore, the issues related to the preservation of cultural heritage today are quite topical. This primarily applies to intangible cultural heritage, which includes such elements as oral traditions, performing arts, ritual and game culture, methods and technology, in other words the certain cultural spaces. Russia also pays a lot of attention to the identification and preservation of the national intangible cultural heritage. If only two objects are included in the List of UNESCO intangible cultural heritage, so the similar lists of objects of federal importance comprise about a hundred. It’s only the beginning. This article examines the cultural space that is worthy to be included in the List of intangible cultural heritage of humanity. It is based on the culture of the East Slavic tribe of Vyatichi, who settled in the VIII–XII centuries the South-Eastern part of present-day Central Federal District. During the later centuries, this cultural space was developed by the residents of Moscow, Ryazan, Kaluga, Tula, Orel and other Russian provinces (oblasts). To date, cultural space, formed by the descendants of the Vyatichi, represents a unique tourism product that has a sufficiently high attractiveness. The article also discusses the possibility of the implementation of this tourism product in certain entities of the Russian Federation
TOURISM AND INTANGIBLE CULTURAL HERITAGE: KARELIAN-FINNISH EPIC POEM «KALEVALA» AS ATTRACTOR IN INFORMATION FIELD OF DESTINATION
Authors: Колесников Николай , Kolesnikov Nikolay , Колесникова Наталья , Kolesnikova Natalya , Плотникова Виктория , Plotnikova Viktoriya
Published: September 2016

The article investigates the forms and principles of involving intangible cultural heritage in tourism development thought the example of the Republic of Karelia. Various forms of intangible cultural heritage are presented according to the UNESCO Convention for the Safeguarding of the Intangible Cultural Heritage 2003. Forms of using of intangible cultural heritage in the framework of the various types of tourism organization are explored through the certain examples. The authors consider 4 conditions of legend’s involvement in the service process in the territory of tourism destination according to the «Scheherazade strategy» by Christian Salmon: (1) submission of natural and cultural heritage through the history / legend; (2) certain time of story / legend providing; (3)«message» of tourism destinations; (4) creation of information field on the Internet. The authors specify the 3rd point and formulated it as «formation of cultural anchor» that should «tie» specific local legend to places and objects located in the territory.

The intangible cultural heritage involvement in the process of tourist services organization is considered by the example of the Karelian-Finnish epic poem «Kalevala», consisting of 50 runes (the Republic of Karelia). Experience of the «Kalevala» epic poem involvement in tourism is considered: tourism routes development, creating and adaptation of legends, development of event and adventure tourism. The possibility of implementing the updated «Scheherazade strategy» by the example of the epic poem «Kalevala» is investigated. As the research result, the authors propose an annual roleplaying game «Kalevala. Amazing adventure» as the new actual form of promotion «Kalevala» epic poem. This project was developed by students and lectures of Tourism Department of Petrozavodsk State University and included to the Small Deal Strategy of Kalevala region of the Republic of Karelia.

This article was prepared as part of the scientific activities of the Strategic Development Program of Petrozavodsk State University for 2012–2016.
Schizophrenia and anorexia nervosa – reciprocal relationships. A literature review
Authors: Morylowska-Topolska Justyna , Ziemiński Rafał , Molas Agnieszka , Gajewski Jacek , Flis Marta , Stelmach Ewa , Karakuła-Juchnowicz Hanna
Published: September 2016

Pomiędzy objawami tak pozornie od siebie odrębnych zaburzeń psychicznych jakimi są schizofrenia oraz jadłowstręt psychiczny istnieją różnego typu zależności. W artykule dokonano przeglądu literatury i podsumowano poglądy różnych autorów na temat powiązań tych dwóch zaburzeń.
Objawy anoreksji mogą 1) poprzedzać wystąpienie psychozy, 2) pojawiać się w jej aktywnej fazie lub też rzadziej występować w okresie remisji, ale także z drugiej strony 3) w przebiegu jadłowstrętu psychicznego mogą okresowo pojawić się objawy psychotyczne. Gdy anoreksja wyprzedza ujawnienie się psychozy, możemy traktować objawy anoreksji jako składową fazy prodromalnej. Inną możliwością współistnienia psychozy (np. schizofrenii) z anoreksją jest sytuacja, gdy zespół zaburzeń odżywiania się pojawia się w tym samym czasie co pełnoobjawowy zespół psychotyczny. W przypadku zaś, jednoczasowego występowania objawów obu zaburzeń trudno często rozróżnić, czy jest to schizofrenia, w przebiegu której na podłożu psychotycznym pojawiają się objawy anoreksji, czy też anoreksja podczas której ujawniają się objawy psychotyczne, najczęściej wówczas tematycznie związane z odżywianiem się.
Opublikowane do tej pory doniesienia, głownie opisy przypadków, wskazują na złożoną naturę wzajemnych związków schizofrenii i jadłowstrętu psychicznego. Konieczne są dalsze badania, które pomogłyby ostatecznie wyjaśnić powiązania zaburzeń psychotycznych z jadłowstrętem psychicznym, co umożliwiłoby stosowanie skuteczniejszego leczenia w tej grupie pacjentów.
Studi Katalis Ni Nano pada Material Penyimpan Hidrogen MgH2 yang Dipreparasi melalui Teknik Mechanical Alloying
Authors: Sari Nirmala , Rahwanto Adi , Jalil Zulkarnain
Published: September 2016

The main obstacle which hinders the application of fuel cell fuels in motor vehicles today is the hydrogen storage tubes. One of the latest efforts in hydrogen storage research is to insert hydrogen in certain metals or called solid state hydrogen storage. Magnesium (Mg) is regarded as one of the material potential candidates absorbing hydrogen, because theoretically, it has the ability to absorb hydrogen in the large quantities of (7.6 wt%). This amount exceeds the minimum limit which is targeted Badan Energi Dunia (IEA), that is equal 5 wt%. However Mg has shortage, namely its kinetic reaction is very slow, it takes time to absorb hydrogen at least 60 minutes with very high operating temperatures (300-400 °C). The aim of this study is to improve the hydrogen desorption temperature hydrogen storage material based MgH2. In this method, milling of material is done in the time of 10 h with the variation of catalyst inserts a for 6wt%, 10wt% and 12 wt%. The results from XRD measurements in mind that the sample was reduced to scale nanocrystal. Phase that appears of the observation of result XRD is MgH2 phase as the main phase, and followed by Ni phase as minor phase. The result of observations with DSC, to the lowest temperature obtained on the sample with a weight of catalyst 12 wt% Ni catalyst that is equal to 376 °C. These results successfully repair pure temperature of Mg-based hydrides.
Simulasi Numerik Reaksi Fusi Nuklir dengan menggunakan Metode Wong
Authors: Firihu Muhammad Zamrun , Variani Viska Inda , Justina J
Published: September 2016

The numerical simulation for calculating the cross section of fusion reaction is done by using Wong formula. We especially calculated the cross section for the fusion reaction of light systems, i.e. 12C+12C, 16O+12C and 16O+16O reactions. We compared the obtained cross section with experimental data. In order to check the accuracy of the calculations, the chi-square analisys is then permormed. We found that the simulation results of the fusion cross section obtained using Wong Formula well explain the experimetal data of the fusion cross section for the 12C+12C, 16O+12C and 16O+16O reactions. This finding indicates that the Wong formula can be used for studing the fusion reaction of light systems.
How to address citizens’ practices and policies on sustainability? A consultative tool for brokering policy-related knowledge between the worlds of policymaking and everyday citizens’ life
Authors: Espluga Josep , Konrad Wilfried , Mays Claire , Oltra Christian , Poumadère Marc , Prades Ann
Published: September 2016

An innovative investigative approach (STAVE), combining elements of research, engagement and brokerage, was used to uncover policy assumptions and daily experiences related to energy use practices. Exploratory work within three policymaker institutions and eight reconvened focus groups were carried out in three different European countries (France, Germany, Spain). All the groups explored active practices with regard to energy saving at household level, with the use of in-home display devices and smart meters additionally addressed in Spain and France. Insight gained by policymakers could be adopted to design, implement and tailor energy plans and policies to better support sustainability.
BELMOND HOTEL DAS CATARATAS: investigação das transformações ocorridas a partir da implantação do SGA NBR ISO 14001
Authors: Jacomelli Eloise , Rodrigues Zaidyani Gabine , Hack Eduardo
Published: September 2016

O artigo trata de um resgate do processo de implantação do SGA - iniciado com a empresa Tropical Hotels & Resorts (de 2000 até 2007), até os investimentos e resultados alcançados pelo grupo Orient- Express Brasil S/A (de 2007 até meados de 2014). De forma geral, objetiva-se investigar as transformações ocorridas dos elementos indicativos e práticas a partir da implantação do SGA. Especi camente, descrever o processo de implantação destes sistemas dos dois grupos hoteleiros, levantar os indicadores e práticas de Gestão Ambiental, e veri car a variabilidade estatística (desvio padrão) dos elementos indicativos das práticas de gestão ambiental (consumo esperado versus consumo real). Os métodos caracterizam-se com o uso de técnicas qualitativas e quantitativas, com bases exploratórias e descritivas, o instrumento utilizado fora à entrevista semiestruturada, com técnica de análise de conteúdo, aplicado com a Coordenadora de Aprendizagem e Desenvolvimento, com o Gerente de Manutenção e com o Supervisor de Tecnologia da Informação do hotel sobre os indicadores ambientais aplicados na empresa. Os resultados alcançados demonstram que a organização continua trabalhando de forma adequada o SGA, sobretudo, busca soluções que reduzam o consumo de água, energia, gás natural, dentre outros indicadores. Ao nal demonstram-se propostas de melhora ao empreendimento.Palavras-chave: ISO 14001; Gestão Ambiental; Sistema de Gestão Ambiental; Indicadores de Gestão Ambiental.
HABILIDADES NA CAPTAÇÃO E NEGOCIAÇÃO DE PROJETOS TURÍSTICOS: A percepção dos consultores
Authors: Novaes Marlene Huebes , Pernanchini Alan Ceratti
Published: September 2016

O presente artigo busca elencar, através de uma pesquisa realizada com pro ssionais da área de consultoria, as habilidades utilizadas pelos mesmos durante as etapas de captação e negociação de projetos turísticos, comparando com as habilidades publicadas por autores especialistas da área. A metodologia aplicada foi pesquisa do tipo bibliográ ca, exploratória, quantitativa com análise multivariada de clusters. Através deste método formaram-se três grupos, compostos pelas respostas dos entrevistados, buscando através de uma distância denominada euclidiana a dissimilaridade desses grupos. Na análise dos clusters, foi possível perceber as diferenças e semelhanças geradas pelos grupos, como a maneira que os consultores da área classi cam o processo de desenvolvimento de suas habilidades, durante o processo de consultoria. Grande parte dos entrevistados destacou como a principal in uência para o desenvolvimento de novas habilidades as pesquisas, artigos, publicações sobre o comportamento do consumidor, mercados e tendências, leitura de livros relacionados à vendas, negociações e elaboração de projetos. O que permite inferir que o desenvolvimento de habilidades é essencial no decorrer da carreira de um consultor. Ressalta-se a necessidade dos consultores buscarem o desenvolvimento constante para agregar valor aos seus serviços.Palavras-chave: Turismo. Hotelaria. Consultoria. Habilidades.
Moving Beyond Assessment to Improving Students’ Critical Thinking Skills: A Model for Implementing Change
Authors: Haynes Ada , Lisic Elizabeth , Goltz Michele , Stein Barry , Harris Kevin
Published: September 2016

Abstract: This research examines how the use of the CAT (Critical thinking Assessment Test) and involvement in CAT-Apps (CAT Applications within the discipline) training can serve as an important part of a faculty development model that assists faculty in the assessment of students’ critical thinking skills and in the development of these skills within their courses. Seventy-five percent of faculty participating in a CAT scoring workshop at their institution reported greater understanding of students’ strengths and weaknesses in critical thinking and 45% reported that CAT scoring had changed their teaching practices and/or assessment. In addition, participants attending a training session on CAT-Apps reported a greater willingness to place more emphasis on critical thinking assessments and less on factual knowledge assessments in their courses as a result of participation in training.
“I Tolerate Technology—I Don't Embrace It”: Instructor Surprise and Sensemaking in a Technology-Rich Learning Environment
Authors: Fairchild Jennifer , Meiners Eric B. , Violette Jayne
Published: September 2016

Assuming a dialectical approach to technology and pedagogy, this study explores sensemaking processes for instructors teaching in a technologically enhanced college classroom environment. Through a series of semi-structured individual and group interviews, seven instructors provided narrative accounts of the problems encountered with progressive instructional technology and their emergent strategies to make sense of and manage it. Three primary dialectical tensions were described: freedom vs. confinement, connectedness vs. fragmentation, and change vs. stability. Two related modes of sensemaking in response to these tensions were also uncovered: adaptation, involving day-to-day adjustments to non-routine failures, and reframing, entailing gradual reflection upon the instructors’ roles in the classroom. Implications for the current findings are discussed.
An Investigation of the Relationship between In-Class and Out-of-Class Efforts on Student Learning: Empirical Evidence and Strategy Suggestion
Authors: Lin Tin-Chun
Published: September 2016

In this paper we explore and discuss an important research question in higher education – is there a trade-off relationship between in-class and out-of-class efforts for students? We used an empirical model to test the trade-off hypothesis between these two efforts. We identified a trade-off between in-class and out-of-class efforts, especially for those students who do not perform well on examinations. We clarified possible reasons for this relationship in a lower-performing student group and noted potentially harmful implications for higher education. We recommended that instructors work individually with students in setting appropriate goals for each exam and frequently offering feedback. Doing so can strengthen rapport between students and faculty, thereby enhancing students’ motivation to learn and confidence in utilizing faculty as a learning resource. We also recommended a classroom-based game play strategy to promote students’ motivation to learn and encourage their participation.
You Can Lead Students to Water, but You Can't Make Them Think: An Assessment of Student Engagement and Learning through Student-Centered Teaching
Authors: Bradford Jennifer , Mowder Denise , Bohte Joy
Published: September 2016

The current project conducted an assessment of three student-centered teaching techniques in a criminal justice and criminology research methods class: Team-Based Learning, Incentive-Based Learning, and Flipped Classroom. The project sought to ascertain to what extent these techniques improved or impacted student learning outcomes and engagement in this traditionally difficult course. Results provide empirical evidence that students were significantly engaged with the course and benefited from these pedagogical techniques.
Contribuição do manufacturing execution system na execução de prioridades competitivas em empresas de manufatura
Authors: Vargas Elisandro João de , Sellitto Miguel Afonso
Published: September 2016

O objetivo deste artigo é analisar os resultados que a implantação de um sistema de informação do tipo MES (Manufacturing Execution System) pode trazer a empresas de manufatura. O método de pesquisa foi o estudo de caso múltiplo. Foram estudadas duas empresas de médio porte (X e Y), com características diferentes de produto e processo, com implantações do MES, durando sete e dez anos. Os resultados apontam que entre 2011 a 2014 ocorreu melhora nas prioridades competitivas custo e entrega para a empresa X e qualidade, custo e entrega para a empresa Y. Os principais resultados observados e que podem ser atribuídos às implantações do MES são: em X, aumento no tempo de máquina operando em 32%, redução do lead time em 47,6% e custos de fabricação em 9,7%; em Y, redução dos rejeitos em 52,6%, custos de fabricação em 8,7% e no lead time em 20%.
The Feldstein-Horioka hypothesis revisited
Authors: Dzhumashev Ratbek , Cooray Arusha
Published: September 2016

Feldstein-Horioka hypothesis states that if there is perfect capital mobility, low correlation between domestic investment and savings should be observed. However, empirical analysis failed to confirm the hypothesis. This study attempts to shed a new light on international capital mobility by incorporating the effect of the fiscal balance and the financial balance. Specifically, for a panel of 161 countries over the 1990–2013 period, the extended model is tested in comparison with the existing models of capital mobility. At the aggregate level, strong support is found for the extended model; while, at the region disaggregated level, compared to the existing models the hypothesis of capital mobility holds for a larger number of regions. Our model and estimates are additionally extended to account for the fact that the above mentioned relationships, are conditional on the country’s level of financial development.
Synthesis and characterization of polyHIPE composites containing halloysite nanotubes
Authors: Hande Mert Hatice , Şen Sinan
Published: September 2016

High internal phase emulsion templated-polymer (polyHIPE) composites were prepared from spirulina modified halloysite (HL) nanotube containing styrene/divinylbenzene based water-in-oil type concentrated emulsions. In order to obtain a stable emulsion for neat polyHIPE’s synthesis, at least 5 vol% Span-80 as a non-ionic surfactant, with respect to organic phase was needed. For syntheses of polyHIPE composite structures, this amount was decreased to 2 vol%, even in presence of 0.25 wt% modified nanotube with respect to the organic phase. All the polyHIPE composites exhibited open pore structures with pore interconnections together with partially or completely closed pores. The composite having 0.25 wt% modified nanotube and 2 vol% surfactant was found to have about 260% higher dye adsorption capacity and the highest onset degradation temperature in comparison with neat polyHIPE.
Application Scenarios of Smart Glasses in the Industrial Sector
Authors: Hobert Sebastian , Schumann Matthias
Published: September 2016

Many companies in the industrial sector are currently facing massive changes in order to optimize processes and enable new customer demands (e. g. mass customization of products). Often, these changes are related to a modernization of existing infrastructure to enable cyber-physical systems and smart factories (so called Industry 4.0). These structural changes have effects on business processes and business models. Consequently, the factory workers need to adapt to the changing infrastructure and therefore, it is necessary to analyze how factory workers can be supported during their day-to-day work in the changed environment. Thus, an important aspect is the analysis of human computer interaction interfaces which aim at assisting factory workers. One promising human computer interface solution between cyber-physical systems and factory workers are smart glasses, as this technology is suited for assisting humans hands-free. Since prior research on application scenarios of smart glasses in the industrial sector is limited, the aim of our research is to identify relevant application scenarios. Therefore, we conducted a qualitative, explorative study by interviewing 21 domain experts. Based on this, we derived 15 application scenarios which can be used by both, research and practice, to develop and evaluate new human computer interaction interfaces for industrial applications.
Photo-enriched Documentation during Surgeries with Google Glass: An Exploratory Usability Study in a Department of Paediatric Surgery
Authors: Mentler Tilo , Kappel Janosch , Wünsch Lutz , Herczeg Michael
Published: September 2016

Due to hygienic regulations and mobility requirements, medical professionals show great interest in wearable devices allowing for hands-free interaction and ubiquitous information access. Smartglasses like the prototype “Google Glass” have already been evaluated in pre-hospital as well as clinical medical care. Based on laboratory studies according to the reliability of voice and gesture recognition and field studies during four surgeries in the department of paediatric surgeries, we discuss usability and acceptance of smartglasses for photo-enriched documentation during surgeries. While technical limitations (e. g. poor camera quality) have to be overcome, usable solutions for human-smartglasses interaction by voice and gesture recognition seem to be possible midterm. Surgeons and other members of surgical teams are curious about smartglasses in their working environment. This can be a starting point for a wider use, if user interface and interaction design for smartglasses are further explored and developed in a user-centered process meeting their requirements. In this regard, transmodal consistency is recommended as a design principle for applications supporting multiple input and output modalities.
Usable Security – Results from a Field Study
Authors: Iacono Luigi Lo , Nguyen Hoai Viet , Schmitt Hartmut
Published: September 2016

Security has evolved into an essential quality factor of software systems. However, security features in software applications are often time-consuming, error-prone and too complicated for common users. This is mainly due to a limited consideration and integration of usability. As a consequence, users either circumvent security features or do not utilize them at all. Usable security is an advanced quality topic and an important research area of software systems. This area combines usability and security with the objective of making the use of security features in software effective, efficient and satisfying. In order to meet this challenge, the research project USecureD aims at supporting small and medium-sized enterprises (SMEs) in facilitating the selection and incorporation of usable security by developing, evaluating and collecting principles, guidelines, patterns and tools for merging usability and security engineering. During the initiation phase of the USecureD project, an online study (N = 118) in conjunction with 10 interviews and 2 workshops have been conducted in order to identify the relevance and requirements of usability, security and usable security with a specific focus on SMEs. The obtained results are presented and derived implications are discussed in this paper.
Multimodal Features and Probability Extended Nearest Neighbor Classification for Content-Based Lecture Video Retrieval
Authors: Waykar Sanjay B. , Bharathi C. R.
Published: September 2016

Due to the ever-increasing number of digital lecture libraries and lecture video portals, the challenge of retrieving lecture videos has become a very significant and demanding task in recent years. Accordingly, the literature presents different techniques for video retrieval by considering video contents as well as signal data. Here, we propose a lecture video retrieval system using multimodal features and probability extended nearest neighbor (PENN) classification. There are two modalities utilized for feature extraction. One is textual information, which is determined from the lecture video using optical character recognition. The second modality utilized to preserve video content is local vector pattern. These two modal features are extracted, and the retrieval of videos is performed using the proposed PENN classifier, which is the extension of the extended nearest neighbor classifier, by considering the different weightages for the first-level and second-level neighbors. The performance of the proposed video retrieval is evaluated using precision, recall, andF-measure, which are computed by matching the retrieved videos and the manually classified videos. From the experimentation, we proved that the average precision of the proposed PENN+VQ is 78.3%, which is higher than that of the existing methods.
Thermal degradation of coir fiber reinforced low-density polyethylene composites
Authors: Prasad Nirupama , Agarwal Vijay Kumar , Sinha Shishir
Published: September 2016

In the present study, the effect of fiber surface treatments (alkali and acrylic acid) on the thermal degradation behavior of coir fiber (CF)-low-density polyethylene (LDPE) composites with or without compatibilizer (maleic anhydride grafted LDPE, MA-g-LDPE) using thermogravimetric and derivative thermogravimetric analyses (TG/DTG) was analyzed and compared with those of untreated fiber composites. The TG/DTG results revealed that the thermal stability of the CF improved after the chemical treatments. However, the composite containing treated fiber showed lower thermal stability and started to degrade at a faster rate above 380°C in comparison to composites containing untreated fiber composites. Furthermore, the addition of MA-g-LDPE led to improvement in the thermal stability of both treated and untreated fiber composites in comparison to the same composite formulation without MA-g-LDPE. The composite containing untreated fiber and MA-g-LDPE demonstrated superior thermal stability among all the formulated composites, indicating strong fiber-matrix adhesion.
Re-survey and spatial analysis of landscape developments during the first millennium BC on Cyprus
Authors: Kearns Catherine
Published: September 2016

The narrative of socio-political development on the semi-arid island of Cyprus during the early first millennium BC (c. 1100–500) has focused largely on the institutions, practices and material culture of major centres and their interrelationships with growing maritime networks. Less studied are the landscapes surrounding these coastal and inland towns, which helped condition the increasing wealth and power of authorities through the management of agropastoral and metal goods, and through the creation of new mortuary, ritual and community spaces (Iacovou 2014). These regional contexts, whose settlements and land-use practices have now been recorded through several survey projects, provide a rich yet under-used source of material for investigating social transformations during this period. Ongoing interdisciplinary work in the Vasilikos and Maroni Valleys of south-central Cyprus has begun systematic analysis of these landscape changes and their long-term contexts. The project is focused on a 150km2 research area situated 20km east of the ancient polity of Amathus, extending from the central Troodos massif down to the coast (Figure 1).
A fifth-millennium BC cemetery in the north Persian Gulf: the Zohreh Prehistoric Project
Authors: Moghaddam Abbas
Published: September 2016

The Zohreh Prehistoric Project (ZPP), a long-term archaeological research programme focused on the river valley south of the modern city of Behbahan in Khuzestan Province, was launched in April 2015 (Figure 1). The valley, which lies in close proximity to the northern coast of the Persian Gulf, was surveyed extensively during the early 1970s by Hans Nissen from the Oriental Institute of the University of Chicago (Nissen & Redman 1971; Dittmann 1984, 1986). The ZPP aims to develop full-coverage archaeological survey of the valley, focusing on the human landscape over time, mostly in relation to settlement hierarchy and dynamics, modes of production and the emergence of regional centres at the end of the fifth and beginning of the fourth millennia BC. The focal point for the project is the principal site of the Zohreh Valley, known as Tol-e Chega Sofla (39RN1Q22108; the site was previously registered as Chogha Sofla, BZ.71 (Dittmann 1984: 110). We have changed this to reflect its local name. The digital reference is the unique Iranian archaeology map registration number.
Seeds of collapse? Reconstructing the ancient agricultural economy at Shivta in the Negev
Authors: Fuks Daniel , Weiss Ehud , Tepper Yotam , Bar-Oz Guy
Published: September 2016

Lessons from history on sustainability, collapse and resilience are the ultimate goal of the Byzantine Bio-Archaeology Research Program of the Negev (BYBAN) (Tepperet al.2015). Addressing the unprecedented flourishing and collapse of the Byzantine Negev agricultural settlements (fourth–seventh centuries AD), the BYBAN project offers a unique and original approach. It focuses on ancient middens and domestic contexts, which provide an exceptional focus on the materiality of daily life. Archaeobotanical research is central to this project because the copious plant remains retrieved are a reflection of the region's agricultural economy and its environmental sustainability. This approach will enable us to answer important research questions about the Byzantine–Islamic transition in the Negev: what were the major cash and subsistence crops? Which were grown locally, and which, if any, were imported? How, if at all, did the agricultural economy change during the Byzantine–Islamic transition? Were there any major changes in climatic conditions, and, if so, can they be implicated as a cause for agricultural collapse?
Global longitudinal strain: a useful everyday measurement?
Authors: King A. , Thambyrajah J. , Leng E. , Stewart M. J.
Published: September 2016

Herceptin (Trastuzumab) is a widely used and effective drug for the treatment of Her2+ breast cancer but its cardiotoxic side effects require regular monitoring by echocardiography. A 10% reduction in left ventricular ejection fraction can lead to suspension of treatment and therefore has significant implications for patient prognosis in terms of cardiac and cancer outcomes. Assessment of LV function by conventional 2D biplane method of discs (2DEF) has limitations in accuracy and reproducibility. Global longitudinal strain (GLS) is becoming more widely available and user friendly. It has been shown to demonstrate myocardial damage earlier in treatment than 2DEF, allowing the option of pharmacological intervention at a pre-clinical stage and preventing the interruption of Herceptin. This study compares the reproducibility of GLS with that of 2DEF in a routine clinical environment. Fifty echocardiograms performed on female patients undergoing Herceptin treatment were used to measure both 2DEF and GLS within the recommended standard appointment time of 40 min. The data were re-measured (blind) by the same operator a minimum of 14 days later to determine intra-operator variation. These data were also measured by a second operator (blind), to assess inter-operator variation. Analysis by direct comparison, intra-class correlation (ICC), coefficient of variation (CV) and Bland–Altman plots demonstrated that GLS is a more reproducible measurement than 2DEF. This is important to prevent clinical decisions being erroneously based on variation in operator measurement. The investigation also shows that with advances in machine software this is a practical addition to routine assessment rather than merely a research tool.