bluuebunny/crossref_metadata_2025 huggingface dataset:
Effect of Zinc Consumption on Salivary Interleukin 1-Beta Levels in Periodontitis: An Experimental Study on Periodontitis Male Wistar Rats.
Authors: Tofrizal Tofrizal , Fitri Haria , Fajrin Fildzah Nurul , Ernesto Gian , Juwita Dinda Ratna , Octaricha Tasha , Kasuma Nila
Published: June 2022

Micronutrients such as Zn are known for their benefits in cell metabolism and enzyme modulation during inflammation. Although Zn is known to benefit cells in the body, few studies have examined its role in curing periodontal disease. The purpose of this study is to analyze the relationship of oral consumption with interleukin 1-beta levels in saliva, which is the main cytokine secreted during the inflammatory process. This post-test design experimental study was carried out on 40 male Wistar rats divided into 4 groups, namely, the control group, periodontitis, periodontitis who were given Zn supplementation, and periodontitis were given a low Zn diet, each group consisted of 10 rats studied through the induced ligature method. Ligature wire was removed after 14 days, zinc sulfate supplementation was given for 14 days by the foundation method. Rat saliva was collected on day 15. Interleukin 1 beta levels in saliva were analyzed by the ELISA Sandwich method. The measurement results were analyzed statistically by ANOVA test on IBM SPSS 15. The results showed that there were significant differences in clinical parameters between each group (p = 0.003). There were differences in the levels of IL-1Β in saliva between the treatment groups. Significantly different groups were the periodontitis group with the control group, periodontitis with periodontitis that were given Zn supplements, and periodontitis with periodontitis that were given a low Zn diet (p = 0.0005). Zinc can reduce the levels of proinflammatory cytokine IL-1B. Therefore, consumption of oral zinc can help cure periodontal disease.
Analysis of Clinical Features and Inflammatory Related Molecules with The Disease in Acute Infectious Urticaria.
Authors: Liu Zhezhang , Al-Quran Lina , Tong Jianbo , Cao Xianwei
Published: June 2022

Acute infectious urticaria, a subset of acute urticaria, with severe persistence wheals and systemic symptom, are responded well to corticosteroid treatment in combination with antibiotic. The exact pathogenic mechanisms are not fully understood. Our aimed was to analyze the different clinical features between acute infectious urticaria and acute urticaria and to investigate the expression of cytokines and chemokines in acute infectious urticaria that may be involved. There are 18 patients with acute infectious urticaria and 18 patients acute non-infectious urticaria were included in this study. We analyzed the differences between the clinical features and the serum expression of pro-inflammatory factors in the two groups. We further examined the levels of T helper cell (Th cell)-associated cytokines and infection-related chemokines before and after treatment of acute infectious urticaria. Neutrophil granulocytes, leukocytosis, inflammatory markers (IL-6 and CRP) and fibrinolysis (D-dimer) were significantly higher in acute infectious urticaria than in acute urticaria. No significant difference was found between the serum levels of TNFα, IL -4, IL -17 before and after treatment, but the serum expression levels of chemokine ligand 8 (CCL8) were higher before treatment in acute infectious urticaria than after treatment. In this study, both CCL8 and CRP were positively correlated with neutrophil granulocytes. In addition, there was a significant correlation between CRP level and IL-6. Neutrophil granulocyte activation, which was significantly correlated with high expression of CCL8, may be involved in the pathogenic mechanism of acute infectious urticaria.
Weight perception and Self-rated Health: Are There Differences Between Cancer Survivors and Non-Cancer Survivors?
Authors: Lee Kayoung
Published: June 2022

Purpose: To compare relationships between self-perceived weight and self-rated health (SRH) between cancer survivors and non-cancer survivors.Methods: A cross-sectional study based on the 2014–2019 Korea National Health and Nutrition Examination Survey was conducted for the associations of self-perceived weight status, measured BMI categories, and combined categories by self-perceived weight and measured BMI with SRH in 1622 cancer survivors and 29903 non-cancer survivors using complex samples ordinal regression analysis after adjusting for sociodemographic factors, health behaviors, and concurrent diseases..Results: Compared to the comparison group (those who were normal weight and self-perceived as average weight in non-cancer survivors), adjusted odds for poorer SRH were higher in cancer survivors and non-cancer survivors who were underweight and self-perceived as underweight (adjusted odds ratios[aORs], 2.69 for non-cancer survivors;2.62 for cancer survivors), those who were normal weight but self-perceived as underweight or overweight (aORs, 1.69-2.38 for non-cancer survivors;2.34-3.78 for cancer survivors), and those who were overweight and self-perceived as overweight (aORs, 1.52 for non-cancer survivors; 2.42 for cancer survivors). In cancer survivors, the odds for poorer SRH was greater for those who were normal weight and self-perceived as average weight (aOR=1.84), whereas the odds was not significant for those who were underweight or overweight and self-perceived as average weight. In non-cancer survivors who self-perceived as average weight, the odds for poorer SRH was significant in those with underweight (aOR=1.35) or overweight (aOR=0.84).Conclusion: According to actual weight status, the association between self-perceived weight and SRH may differ between cancer survivors and non-cancer survivors.
Exosomal miR-29b-3p derived from cancer- associated fibroblasts contributes to esophageal squamous cell carcinoma cell progression by NAA60 hypomethylation
Authors: Xia Haifeng , Lu Fei , Pan Liangbin , Xu Chengcheng , Ma Haitao
Published: June 2022

Objectives: Tumor microenvironment plays an important role in tumor progression. Cancer-associated fibroblasts (CAFs) are the main cell types in the tumor microenvironment. Esophageal squamous cell carcinoma (ESCC) is the most common type of esophageal cancer. In this study, we will explore the molecular mechanism of CAFs promoting the effect of esophageal squamous cell carcinoma. Methods: Exosomes secreted by HEEC cells (normal esophageal epithelial cells) and EC109 cells (ESCC cells) were extracted and labeled as EXO-HEEC and EXO-EC109, respectively. Morphology of exosomes was observed by electron microscope. The expression of exosome specific marker protein was detected by Western blot. The expression of miR-29b-3p in exosomes was detected by qRT-PCR. EC109 cell line was constructed to interfere with miR-29b-3p. Tumor cell proliferation was detected by CCK-8 assay and tumor cell invasion was detected by Transwell assay.Results: We demonstrated hypomethylation of the promoter of NAA60 in ESCC-associated fibroblasts, and that overexpression of NAA60 induces the transformation of fibroblasts into cancer-associated fibroblasts. In addition, our results showed that the expression level of NAA60 increased significantly after DNMT3A interference, and miR-29b-3p was most significantly expressed in exosomes and miR-29b-3p had the best binding with DMNT3A. Further experiments confirmed that interference of miR-29b-3p inhibited the progression of ESCC cells through NAA60 hypomethylation after transferring from CAFs to cancer cells. Conclusions: This study showed that CAFs promote ESCC progression through exosomal miR-29b-3p, and suggested that inhibition of CAFs-derived miR-29b-3p maybe an alternative approach for ESCC treatment.
The Size and Behavior of Virtual Objects have influence on Functional Exercise and Motivation of Persons with Multiple Sclerosis: a randomized study
Authors: Cikajlo Imre , Hukić Alma , Pertot Anja Udovčić
Published: June 2022

BackgroundThe consequences of multiple sclerosis are problems related to movement of extremities, coordination and vision. Heretofore frequent treatment with additional medications can change the course of the disease. Motor relearning of small range movements are important to support daily living activities. We have designed a virtual environment for pick and place task. The user hand and finger movements were tracked with a small infrared camera. The primary objective of the study was to examine the influence of size and behavior of virtual cubes on motor control, motivation and functional performance. The secondary objective was to examine the changes of heart rate and intensity of the task due to the different size and behavior of the virtual objects.MethodsIn the randomized study 84/107 eligible inpatients with multiple sclerosis participated. They were randomized into 4 groups by computer random function; group 1 - small and bouncing, group 2 - small and non-bouncing, group 3 - big and bouncing and group 4 - big and non-bouncing virtual cubes. Each participant took 50 sessions, each up to 2 min in approximately 14 days. Before commencement of the study the participants took visual-spatial and cognitive tests. The participants’ subjective experiences was assessed daily with Intrinsic Motivation Inventory. Box and Blocks Test was carried out before and after the study.ResultsIn the study the group 4 was the most successful (inserted cubes > 9) and the fastest (63.4 SD 25.8 s). The group 1 was the slowest (88.9 SD 28.2 s), but with high interest/enjoyment rate and pressure/tension at high heart rate. There were substantial differences in intrinsic motivation between the 1st and the last session within the groups (Cohen's U3 < 0.3 or > 0.8). Kinematic analysis showed differences between the groups (average manipulation time p = 0.008, inserted cubes p = 0.004).ConclusionsThe size and behavior of virtual objects may be crucial for the motivation of participants with equal visual-spatial and cognitive capabilities while maintaining effort and keep trying to improve their performance. Furthermore, the clinical outcomes can confirm the effectiveness of the approach.Trial registration: The small scale randomized pilot trial has been registered at ClinicalTrials.gov Identifier: NCT04266444, 12 February 2020, https://clinicaltrials.gov/ct2/show/NCT04266444
Computed tomography bronchus sign subclassification during radial endobronchial ultrasound-guided bronchoscopy: a retrospective analysis
Authors: Imabayashi Tatsuya , Matsumoto Yuji , Uchimura Keigo , Furuse Hideaki , Tsuchida Takaaki
Published: June 2022

Background: The presence of computed tomography bronchus sign (CT-BS) substantially increases the diagnostic yield of peripheral pulmonary lesions (PPLs) through enhanced lesion identification with radial endobronchial ultrasound (rEBUS). However, the clinical significance of subdividing CT-BS remains controversial. Therefore, the aim of this study was to evaluate the diagnostic impact of CT-BS subclassification, integrating previously reported classifications.Methods: We retrospectively reviewed patients who underwent endobronchial ultrasound with a guide sheath between April 2012 and October 2015. We classified the bronchus types into six subtypes (types Ia–Ic for CT-BS group I, in which the bronchus led　directly within the lesion, and types IIa–IIc for the group II, in which the bronchus did not) to clarify the differences in their characteristics. We investigated the factors associated with successful rEBUS visualization and diagnosis in CT-BS group I, using a multivariable logistic regression model.Results: A total of 1,327 cases were analyzed, with median diameters of 25.0 mm and 15.6 mm in CT-BS groups I and II, respectively. Our findings in diagnostic yields were that in CT-BS group I, penetrating type Ic was inferior to obstructed type Ia and narrowing type Ib (51.2% vs. 81.2% and 76.3%, P < 0.001), and in CT-BS group II, compressed type IIa, which was typically classified as positive CT-BS, showed no difference when compared with invisible type IIb and uninvolved type IIc (38.0% vs. 32.8% and 34.5%, P = 0.747). Multivariable logistic regression analysis revealed that type Ic had a direct impact on the diagnostic yield (odds ratio: 2.31, P < 0.001) without affecting the rEBUS visualization yield in CT-BS group I.Conclusions: CT-BS subclassification may provide useful information regarding the bronchoscopic technique to facilitate accurate diagnosis of PPLs. The presence of type Ic is a key factor for determining the indication for bronchoscopy in the diagnosis of PPLs with CT-BS.
Gam-COVID-Vac, EpiVacCorona, and CoviVac effectiveness against lung injury during Delta and Omicron variant surges in St. Petersburg, Russia: test-negative case-control study
Authors: Barchuk Anton , Bulina Anna , Cherkashin Mikhail , Berezina Natalia , Rakova Tatyana , Kuplevatskaya Darya , Skougarevskiy Dmitriy , Okhotin Artemiy
Published: June 2022

Background: Monitoring vaccine effectiveness (VE) remains a priority for epidemiological research throughout the COVID-19 pandemic. VE against infection declines with the emergence of new SARS-CoV-2 variants of concern, but VE against the severe disease remains high. Therefore, we aimed to estimate the effectiveness of COVID-19 vaccines used in Russia against lung injury during delta and omicron surges. Methods: We designed a case-control study (test-negative design) to estimate VE against any lung injury associated with COVID-19 between October 1, 2021 – April 28, 2022 (Delta variant dominance period followed by Omicron dominance period). We included the data of patients with symptomatic confirmed SARS-CoV-2 infection referred to the low-dose computer tomography triage centres. Results: Among 23996 patients in the primary analysis, 13372 (55.7%) had any lung injury, and 338 (1.4%) had severe lung injury. The adjusted for age, sex and triage centre VE against any lung injury was 56% (95% confidence interval 54 to 59) for two-dose Gam-COVID-Vac (Sputnik V), 71% (68 to 74) for three-dose Gam-COVID-Vac (booster), 2% (-27 to 24) for EpiVacCorona, and 46% (37 to 53) for CoviVac. VE against severe lung injury was higher for all vaccines in our study. Conclusions: Gam-COVID-Vac remains effective against lung injury associated with COVID-19, and one Gam-COVID-Vac booster can be seen as an appropriate option after a two-dose regimen. EpiVacCorona use in population-based vaccination should be halted until additional effectiveness and efficacy evidence is provided. CoviVac efficacy and safety data are still required to justify its use in a population-based vaccination despite our study results.Trial registration: The joint study of COVID-19 vaccine effectiveness in St. Petersburg was registered at ClinicalTrials.gov (NCT04981405, date of registration — August 4, 2021)
Risk of functional disability associated with solid fuel use and population impact of reducing indoor air pollution in China: a national cohort study
Authors: Ren Ziyang , Sun Weidi , Hou Leying , Shan Shiyi , Zhu Siyu , Yi Qian , Wu You , Guo Chao , Liu Jufen , Song Peige
Published: June 2022

Background In China, numerous people still rely on solid fuel for household use. To date, the association between household solid fuel use and functional disability, and what benefit reducing household solid fuel usage could bring at the population level to China remain unclear.Method Data were from the China Health and Retirement Longitudinal Study. Household fuel was classified as clean or solid for cooking or heating. Functional disability was defined as difficulties in any item of activities of daily living (ADL) or instrumental activities of daily living (IADL). The associations of household fuel use in 2011 and its transitions between 2011 and 2013 with subsequent ADL or IADL disability were assessed with Cox proportional-hazards models. The number of events prevented in a population (NEPP) was generated to estimate how many functionally disabled patients could be rescued by reducing solid fuel usage. Results A total of 6226 and 9730 participants without prior ADL or IADL disability in 2011 were included. Solid (vs. clean) fuel users were more likely to develop ADL and IADL disability, with hazard ratios (HRs) and 95% confidence intervals (CIs) of 1.37 (1.29~1.46) and 1.38 (1.31~1.46) for using both solid cooking and heating fuel. Furthermore, participants that switched heating fuel from solid to clean (vs. keep solid) were about 20% less likely to develop functional disability. Cooking fuel use switching from solid to clean (vs. keep solid) was also negatively associated with IADL disability (HR=0.84, 95% CI 0.74~0.95). Over the next 7 years, raising clean fuel usage to 80% could rescue about 11 million ADL disability and 5 million IADL disability among Chinese aged 45 and older.Conclusion Household solid fuel use was a risk factor for functional disability. Reducing solid fuel usage could help reduce the burden of functional disability in the current aging society of China.
Identification of novel ATRX mutations in Chinese patients with ATRX syndrome related intellectual disability/developmental delay
Authors: Wang Junyu , Yan Huifang , Duan Ruoyu , Xiao Jiangxi , Zhang Yu , Wang Jingmin
Published: June 2022

Background Intellectual disability/developmental delay (ID/DD) is a kind of neurodevelopmental disorders of which the genetic etiologies are to be clarified in majority of the patients. The features of ID/DD patients with hemizygous variants in ATRX in China remains unclear due to the rare reports in worldwide.Methods Clinical data of six Chinese pedigrees with hemizygous variants in ATRX and ID/DD was collected. The information of physical examination, blood tests, metabolism screening of blood and urine, cranial magnetic resonance imaging (MRI), and whole exome sequencing (WES) of each patient was elaboratively analyzed.Result ID/DD patients with hemizygous variants in ATRX in China were characterized by moderate to profound ID/DD, facial malformations (microcephaly, hypertelorism, low nasal bridge and ear deformities), hypotonia and poor malmyelination. Five ARTX variants in six Chinese patients consisted of missense, in-frame deletion and frameshift variants, two of which were novel.Conclusion Six Chinese ID/DD patients were clinically and genetically diagnosed with ATRX mutations related syndrome (ATRX syndrome). And genotype–phenotype correlation was revealed in the participants, which expanded the clinical and genetic spectrum of ATRX syndrome.
An unreported infraspinatus muscle variation – two-headed infraspinatus minor muscle and three-headed fusion with the teres minor muscle
Authors: Koptas Krzysztof , Zielinska Nicol , Tubbs Richard Shane , Olewnik Łukasz
Published: June 2022

The infraspinatus muscle is situated under the scapular spine in the infraspinous fossa and inserts into the greater tuberosity of the humerus. It is a component of a crucial shoulder muscle group, the rotator cuff. There are a few interesting additional muscles in the infraspinal region. In the literature they are called the infraspinatus superficialis, infraspinatus minor and infraspinatus accessory muscles. The infraspinatus minor muscle is described as a superficial muscle bundle running under the scapular spine. During routine anatomical dissection, an unreported variation of the infraspinatus minor muscle was found. It derived from the inferior surface of the scapular spine and the infraspinous fossa. It had two heads. The superior head inserted on the greater tuberosity of the humerus. The inferior head inserted on the tendinous part of the infraspinatus muscle. There was also an unusual fusion of the infraspinatus muscle with the teres minor muscle. In this paper we will discuss the anatomical and physiological relationships of this morphological variation.
Mental Health and Visual Acuity in Patients with Age-related Macular Degeneration
Authors: Fonteh Cheryl N. , Mathias Marc , Mandava Naresh , Manoharan Niranjan , Lynch Anne M. , Navo Roxanne , Patnaik Jennifer
Published: June 2022

Background: Visual acuity (VA) loss has been associated with depression in patients with AMD. However, previous studies did not incorporate subgroups of AMD when correlating VA and mental health. The goal of this study was to describe the relationship between VA and mental health questions in patients with different classifications of AMD, and to identify associations of mental health subscale scores. Methods: AMD patients classified by multi-modal imaging were recruited into an AMD registry. Habitual VA was obtained by ophthalmic technicians using the Snellen VA at distance. At enrollment, patients completed the NEI-VFQ-25, which includes 25 questions regarding the patient’s visual functionality. Median with interquartile-range (IQR) scores on the mental health subscale of the VFQ were calculated by AMD classification and VA groups. Univariate and multivariable general linear models were used to estimate associations between mental health scores and variables of interest. Results: 875 patients were included in the study. Patients with bilateral GA or bilateral GA and NV AMD scored lowest on the mental health subscales with a median (IQR) of 58.2 (38-88) and 59.3 (38-88). When stratified by visual acuity, patients with a habitual VA of 20/200 or worse scored the lowest on mental health subscales scores: median of 43.8 (IQR: 31-62). Patients with a VA of 20/20 scored the highest: 87.5 (IQR: 81-94). Habitual VA of the better- and worse-seeing eye and AMD classification were significantly associated with mental health subscale scores (all p<0.0001 in both the univariate and multivariable analysis, except the VA of the worse-seeing eye in multivariable model p=0.027). Patients enrolled during the COVID pandemic had mental health scores that were 2.7 points lower than prior to the pandemic, but this difference was not significant in univariate (p=0.300) or multivariable analysis (p=0.202).Conclusion: There is a significant association between mental health questionnaire scores and AMD classification, as well as VA in both the better and worse-seeing eyes in patients with AMD. It is important for clinicians to recognize feelings of worry/ frustration in these patients, so they can be appropriately referred, screened, and treated for mental health problems.
Factors Associated with Mortality for Patients with Diabetes Mellitus at Kenyatta National Hospital, 2016 – 2020
Authors: Kweyu Kevin Zepwa , Ireri Victor Murangiri , Siamanda Mugambi Bilhah , Siringo Cyril , Mugo Paul Maina , Momanyi Ann Kemuma , Cheserem Cynthia Jebet , Veke Mary , Chughu Wasike Alexandra , Nduara Bryan Odhiambo , Njeri Mburu Esther , Mbakaya Vallary Mutola , Ngondi Jeremiah , Mwendwa Teresa Kinyari
Published: June 2022

Background: Diabetes mellitus (DM) is a major growing health problem all over the world and especially for the low income countries. Therefore, sociological, clinical and disease factors that affect the disease outcome should be considered when managing DM patients.Objective: We aimed at determining the factors that were associated with in-hospital mortality in patients with diabetes mellitus at Kenyatta National Hospital from 2016 to 2020.Methods: We examined retrospective data from medical records of diabetes patients (n = 323, 48.3% males and 51.7% females) above 12 years admitted into the hospital from 2016 – 2020. Multivariable logistic regression analyses was performed to identify factors associated with in-hospital mortality.Results: Multivariable analysis showed that the odds for mortality were significantly high in those of age above 50 years (odds ratio 26.02, 95% confidence interval 9.54–70.92, p-value < 0.001), with unspecified DM type (OR 6.85, 95%CI 1.23–38.20, p = 0.028), DM type II (OR 3.00, 95%CI 1.35–6.67, p = 0.007), and hypertension (OR 2.94, 95%CI 1.47–5.88, p = 0.002), and nephropathy (OR 2.23 95%CI 1.14–4.38, p < 0.001). Other factors positively associated with in-hospital mortality included cardiovascular diseases, complication of diabetes ketoacidosis, oral hypoglycemic agents, soluble insulin, anti-hypertensives and antibiotics.Conclusion: Overall, the findings of this study suggest that advanced age, DM type II or unspecified type of DM, hypertension and nephropathy are the main drivers of mortality for patients with diabetes mellitus at Kenyatta National Hospital.
New Principles of Differential Equations Ⅴ
Authors: Zhu Hong Lai
Published: June 2022

In this paper, we use the previously proposed Z Transformations to obtain the general solutions of many typical nonlinear partial differential equations, and use the general solutions to get the exact solutions of some definite solution problems.
Health professionals’ licensing: the practice and its predictors among health professional hiring bodies in Ethiopia
Authors: Tesfaye Biruk Hailu , Alemneh Endalkachew Tsedal , Teka Eshetu Cherinet , Wolde Ermias Gebreyohannes , Ashena Wondimu Daniel , Ayalew Firew , Melese Tewodros Abebaw , Biset Fikadie Dagnew , Degefu Bezawit Worku , Kebede Bethlehem Bizuayew , Asemu Yohannes Molla , Gebreyes Meron Yakob , Shewatatek Wudasie Teshome , Mengistu Samuel , Aliyu Matias Azanaw , Endris Fatuma Ahmed , Sahlemariam Eden Workineh , Weldesemayat Genet Kifle
Published: June 2022

Background
Evidence suggests that not all human resource departments have hired their facility staff based on federal licensing standards, with some hiring without an active license. This is common in some, if not all, parts of the country. The paucity of healthcare experts, high turnover rates, employee burnout, and challenges in training and development issues were all key recruiting challenges globally.
Objectives
To assess the practice of health professionals’ licensing and its predictors among hiring bodies in Ethiopia, March 24/2021 –May 23/ 2021.
Methods
A quantitative technique was used in this institution-based cross-sectional study. From March 24 to May 23, 2021, the study was conducted in selected regional health bureaus, zonal health departments, district health offices, and both private and government-owned health facilities across Ethiopia. A stratified sampling strategy was used per region, followed by a simple random sampling technique. Samples were assigned proportionally. A total of 405 health professional hiring bodies were selected to participate in the study. Data was acquired using a pretested semi-structured questionnaire and document review tool. Epi-Data version 4.4.3.1 was used to enter the data, which was then exported to SPSS version 23. We ran a descriptive analysis, as well as bivariate and multivariate regression analyses. Tables, graphs, and pie charts are used to present the results. All data and information were kept confidential.
Results
The analysis included365 hiring bodies and 4991 files of health professionals (1581 from private and 3410 from public health organizations). Out of 365 hiring bodies studied, 66.3% practiced health professional licensing. 2733 (55%), 603 (12%), and 1645 (33%) of the 4991 professionals whose files were checked were found working with active, expired, and no professional license, respectively. Being a private facility (AOR = 21.56; 95% CI = 8.85–52.55), obtaining supervision from a higher organ (AOR = 19.74; 95%CI: 2.3–169.1), and conducting an internal audit (AOR = 2.7; 95% CI: 1.15–6.34) were predictors of good licensing practice.
Conclusion
The licensing of health practitioners was poorly practiced in Ethiopia as compared to the expected proclamation of the country. A system for detecting fake licenses and controlling revoked licenses does not exist in all regions.
Acute Headache Management for Patients with Subarachnoid Hemorrhage: An International Survey of Healthcare Providers
Authors: Maciel Carolina B. , Barlow Brooke , Gobinathan Arravintha , Abu-Mowis Zaid , Peethala Mounika Mukherjee , Merck Lisa H. , Aspide Raffaele , Dickinson Katie , Miao Guanhong , Shan Guogen , Bilotta Federico , Morris Nicholas , Citerio Giuseppe , Busl Katharina M.
Published: June 2022

Background: Severe headaches are common after subarachnoid hemorrhage (SAH). Guidelines recommend treatment with acetaminophen and opioids, but patient data show that headaches often persist despite multimodal treatment approaches. Considering an overall slim body of data for a common complaint affecting SAH patients during their intensive care stay, we set out to assess practice patterns in headache management among clinicians who treat patients with SAH.Methods: We conducted an international cross-sectional study through a 37-question web-based survey distributed to members of 5 professional societies relevant to intensive and neurocritical care from 11/2021-1/2022. Responses were characterized through descriptive analyses; Fisher’s exact test was used to test associations.Results: Of 516 responses, 329/497 (66%) were from North America and 121/497 (24%) from Europe. 379/435 (87%) reported headache as major management concern for SAH patients. Intensive-care-teams were primarily responsible for analgesia during hospitalization (249/435, 57%), while responsibility shifted to neurosurgery at discharge (233/501, 47%). Most used medications were acetaminophen (90%), opioids (66%), corticosteroids (28%) and antiseizure medications (28%). Opioids or medication combinations including opioids were most frequently perceived as most effective, by 169/433 (39%, predominantly intensivists), followed by corticosteroids or combinations with corticosteroids (96/433, 22%, predominantly neurologists). Of medications prescribed at discharge, acetaminophen was most common (303/381, 80%), followed by opioids (175/381 [46%]), and antiseizure medications (173/381, 45%). Opioids during hospitalization were significantly more prescribed by intensivists, by providers managing higher numbers of SAH patients, and in Europe. At discharge, opioids were more frequently prescribed in North America. 299/435 (69%) indicated no change in prescription practice of opioids with the opioid crisis. Additional differences in prescription patterns between continents and providers, and inpatient versus discharge were found. Conclusions: Post-SAH headache in the intensive care setting is a major clinical concern. Analgesia heavily relies on opioids both in utilization and in perception of efficacy, with no reported change in prescription patterns for opioids for most providers despite the significant drawbacks of opioids. Responsibility for analgesia shifts between hospitalization and discharge. International and provider-related differences are evident. Novel treatment strategies and alignment of prescription between providers are urgently needed.
The use of BIM to automated construction and demolition waste management: A literature review from 2009 to 2020
Authors: Schamne Annelise Nairne , Nagalli André , Soeiro Alfredo Augusto Vieira
Published: June 2022

The Architectural, Engineering and Construction (AEC) industry is increasingly improving techniques and tools to reduce impacts of activities in the environment and to minimize construction and demolition waste (CDW). One of these innovations is Building Information Modeling (BIM), which can automate construction and waste management throughout the lifecycle. A literature review at a scientific database was realized considering the period from 2009 to 2020 to verify the application of BIM in waste management at construction sites. The results reveal that most of the publications are from the United Kingdom, the United States, and China. The literature review showed that the main application of BIM to CDW management is at the design stage however, BIM can engage team participation and coordination of activities at all stages of the construction life cycle. Although the use of BIM in CDW allows better control of materials, the studies reveal the necessity to develop better indicators to represent real situations at construction sites and incorporate sustainability practices in the building model. The results also showed that the main barrier to integrate BIM and CDW management is the interoperability between BIM tools, which is an opportunity for future research in this area of study.
Análise espaço-temporal da cobertura do solo do Município de Theobroma, Estado de Rondônia, Brasil
Authors: Zebalos Carlos Henrique dos Santos , Oliveira Raquel Faria Araújo , Soares Edimar Rodrigues , Almeida Ueliton Oliveira de , Melillo Raquel Carnivalle Silva , Cavalcante Edson Rodrigues , Rezende João Wesley
Published: June 2022

A cobertura vegetal é essencial para o equilíbrio do meio ambiente e proteção dos solos. A supressão da vegetação nativa para conversão em lavouras e pastagens põe em risco esse delicado sistema. Neste cenário, a manutenção de altos índices de cobertura vegetal fotossinteticamente ativa durante todo o ano é essencial para a qualidade edáfica. Com a finalidade de monitorar a superfície terrestre, o sensoriamento remoto dispõe de inúmeras técnicas com diferentes graus de sofisticação, este trabalho utiliza-se do sensoriamento por meio da técnica de monitoramento do Índice de Vegetação por Diferença Normalizada (NDVI) para avaliar a dinâmica temporal da cobertura vegetal no Município de Theobroma, localizado no Leste Rondoniense. O trabalho avaliou cinco classes de cobertura do solo: corpos hídricos, solo exposto, vegetação rala, vegetação esparsa e vegetação densa. Os resultados obtidos demonstram que entre os anos de 2015 a 2020 Theobroma perdeu áreas de vegetação florestal à medida que as áreas agrícolas em estado de degradação aumentaram, representando no ano 2020 aproximadamente 70% de toda área agricultável. Isso demonstra a urgência de ações que resultem na diminuição do desmatamento e da degradação das áreas de pastagem e que contribuam para a sustentabilidade dos sistemas produtivos no Município de Theobroma, Estado de Rondônia, Brasil.
A relação entre a governança das águas e o desenvolvimento rural: um resgate teórico
Authors: Armando Milagre Jacinto , Kühn Daniela Dias
Published: June 2022

O artigo discute a relação entre a governança das águas e o desenvolvimento rural, tendo como referência a situação do Brasil. O artigo analisacomo a governança das águas relaciona-se com o desenvolvimento rural e, especificamente, caracteriza as dimensões de governança das águas, descreve as percepções sobre o desenvolvimento rural e explica a relação da governança das águas com o desenvolvimento rural. Método usado consistiu na revisão teórica e como foco de referência o Brasil. O artigo considera que a ampliação da capacidade de acesso à água através da governança descentralizada, democrática, participativa e partilhada é indispensável para o desenvolvimento rural. Por sua vez, práticas de desenvolvimento rural sustentáveis são fundamentais para a governança da água integrada à satisfação das necessidades básicas da população nas zonas rurais.
Foodscape pada Kawasan Heritage
Authors: Prima Listen
Published: June 2022

Foodscape merupakan perspektif baru yang menawarkan integrasi multi elemen antara makanan, orang, dan lingkungan. Pada kawasan heritage yang seringkali hanya bergantung pada bangunan sebagai image kawasan memiliki potensi pengembangan lainnya, khususnya elemen foodscape tersebut. Integrasi tersebut dapat dikembangkan pada Kawasan Sekanak di Kota Palembang yang dikenal lewat keberadaan bangunan-bangunan heritage berupa rumah toko (ruko), rumah tradisional limas, dan dominasi rumah panggung khas Palembang. Integrasi antara kawasan dengan kekayaan heritage dan kuliner sebagai cerminan nilai dan sejarah tersebut menyajikan pemahaman perspektif foodscape yang kuat. Penelitian ini menggunakan metode studi kasus pada Kawasan Sekanak di Kota Palembang dengan menggunakan beberapa tools, yaitu surveys dan mapping analyses, serta studi pustaka. Hasil dari penelitian ini merupakan kajian relevansi antara foodscape terhadap kawasan heritage yang dapat dijadikan sebagai landasan studi atas penelitian lanjut dalam upaya pengembangan kawasan terkait peningkatan multi sektor pembangunan.
Victimization Discourse in Armenia: Turkey as the Other [Ermenistan’da Mağduriyet Söylemi: Öteki Olarak Türkiye]
Authors: JAHANLİ Sabina
Published: June 2022

Egemen söylemin sürdürülmesinde hem pratik hem de dil çok önemlidir. Popülasyona tercih edilen anlamı empoze etmek için ikili karşıtlıklar oluşturulmalıdır. Bu karşıtlıklar, “biz ve onlar” temelinde kimlikler inşa etmeyi amaçlar. İkili karşıtlıklar, Ermeni ulusal kimliğinin inşasında da önemli bir rol oynamıştır. Mitoloji temsilleri, toprak iddiaları (Büyük Ermenistan Projesi) ve Ermeni Soykırımı, 19. yüzyıldan itibaren pratikte Türk düşmanlığını ateşledi.

Kimlik inşasında, Ermeni devletinin kurulmasından sonra iki söylemsel kayma yaşandı. İlk değişim, kimlik inşasının asli unsurlarını dışlayarak Türkiye ile iyi bir ekonomik ilişki kurmak için Türk ötekiliğini en aza indirmeye çalışan ilk başkan Ter-Petrosyan döneminde ortaya çıktı. Robert Koçaryan'ın yeni cumhurbaşkanlığı dönemiyle birlikte, hem ilkel hem de sivil unsurları birleştirerek ulusal kimlik inşasında ikinci söylemsel kayma meydana geldi. Türk Ötekiliği, yeni mağduriyet söylemiyle yeniden ortaya çıktı. Yeni söylemin ana temsili, sadece insanların zihninde değil, ülkenin dış politikasında da Türkiye'yi Öteki olarak hedef alan Ermeni Soykırımı idi. Ermeni soykırımını yeniden siyasi gündeme almak ve Ermeni soykırımının dış politikada tanınması yeni söylemin temel amacıydı.

Tarihsel gerçekleri ve söylemsel değişimleri göz önünde bulundurarak, bu çalışmada Türk ötekiliğinin Ermeni ulus inşasında nasıl önemli bir rol oynadığını ve Koçaryan'ın cumhurbaşkanlığı döneminde Türkiye'yi öteki olarak hedef alarak yeni mağduriyet söyleminin nasıl ortaya çıktığını ve Ermeni dış politikasını nasıl temsil etmeye başladığını analiz etmeyi amaçlıyorum.
The role of basic psychological need satisfaction as a mediator between friendship quality and life satisfaction
Authors: Putri Fanny Eka , Muttaqin Darmawan
Published: June 2022

Friendship quality plays an essential role for adolescents in achieving optimal life satisfaction. However, previous studies have failed to explain friendship quality and life satisfaction fully. This study examines the role of basic psychological need satisfaction in the relationship between friendship quality and life satisfaction. A total of 450 respondents consisting of three groups of 150 early, middle, and late adolescents participated in this study. Data were collected using quota and convenience sampling methods. Friendship quality, basic psychological need satisfaction, and life satisfaction were measured using the McGill Friendship Questionnaire–Friend's Functions, Sub-scale Satisfaction of the Basic Psychological Need Satisfaction and Frustration Scale, and the Indonesian version of the Satisfaction with Life Scale. The hypothesis was tested using regression analysis and SOBEL macro for SPSS. The results show that basic psychological need satisfaction acts as a full mediator between friendship quality and life satisfaction (indirect effect = .330, z = 8.383, p .05). In addition, the satisfaction of the need for autonomy, competence, and relatedness can also be a full mediator between friendship quality and life satisfaction. This finding can be an alternative in explaining this relationship between friendship quality and life satisfaction. In addition, the findings can also be used to develop mental health programs for adolescents.
Recent Improvements in the Treatment of High-Risk Thyroid Cancer
Authors: Lee Eun Kyung
Published: June 2022

Thyroid cancer is one of the slow-growing tumors with excellent oncological outcomes. However, a small set of patients with unexpectedly severe outcomes are usually ignored. Anaplastic thyroid cancer (ATC) remains one of the most aggressive and lethal solid tumors. Recently, dabrafenib and trametinib combination therapy or neoadjuvant BRAF induction therapy has shown promising results. In addition, a combination of targeted drugs, immunotherapy, surgery, and radiation therapy can improve overall survival in ATC patients. Another disease for which there is no breakthrough treatment is radioactive iodine-refractory differentiated thyroid cancer (DTC). To date, multikinase inhibitors (sorafenib, lenvatinib) targeting the growth factor signaling pathway have been developed and approved as anticancer agents for patients with advanced DTC. This review includes results from multikinase inhibitors to the emergence of new target molecules, including rearrangements during transformation (RET) and tropomyosin receptor kinase (TRK).
Clinico-pathologic Factors and Machine Learning Algorithm for Survival Prediction in Parotid Gland Cancer
Authors: Park Seung Min , Kim Se-Heon , Choi Eun Chang , Lim Jae-Yol , Koh Yoon Woo , Park Young Min
Published: June 2022

Background/Objectives: This study analyzed the prognostic significance of clinico-pathologic factors including comprehensive nodal factors in parotid gland cancers (PGCs) patients and constructed a survival prediction model for PGCs patients using machine learning techniques.Materials & Methods: A total of 131 PGCs patients were enrolled in the study.Results: There were 19 cases (14.5%) of lymph nodes (LNs) at the lower neck level and 43 cases (32.8%) involved multiple level LNs metastases. There were 2 cases (1.5%) of metastases to the contralateral LNs. Intraparotid LNs metastasis was observed in 6 cases (4.6%) and extranodal extension (ENE) findings were observed in 35 cases (26.7%). Lymphovascular invasion (LVI) and perineural invasion findings were observed in 42 cases (32.1%) and 49 cases (37.4%), respectively. Machine learning prediction models were constructed using clinico-pathologic factors including comprehensive nodal factors and Decision Tree and Stacking model showed the highest accuracy at 74% and 70% for predicting patient’s survival.Conclusion: Lower level LNs metastasis and LNR have important prognostic significance for predicting disease recurrence and survival in PGCs patients. These two factors were used as important features for constructing machine learning prediction model. Our machine learning model could predict PGCs patient’s survival with a considerable level of accuracy.
A Case of Parathyroid Carcinoma with Spontaneous Infarction
Authors: Geum Sang Yen , Park Hee Jun , Yoo Jae Ho , Kim Jeong Kyu , Lee Dong Won
Published: June 2022

Parathyroid carcinoma is very rare malignant neoplasm, accounting for less than 0.005% of all cancers. Most parathyroid carcinoma is a functioning tumor that causes hyperparathyroidism, leading to hypercalcemia. We report a parathyroid carcinoma case that was suspicious for spontaneous infarction of cancer, leading to resolution of hypercalcemia. A 29-year-old male visited our hospital presenting with right neck swelling and pain. He has been experiencing frequent urolithiasis for four years but laboratory tests showed normal serum calcium level. Right vocal cord paresis was identified with laryngoscopy. Ultrasonography revealed a 3.7 × 3.5 cm mass in the right thyroid containing a focal cystic portion. Computed tomography confirmed the presence of a low-density right thyroid mass. Right thyroid lobectomy was performed and pathological evaluation revealed parathyroid carcinoma with central necrosis. We report this very rare case with a literature review.
A Case of Carcinoma with Sebaceous Differentiation arising in the Patient who was Treated with Parotid Gland Adenocarcinoma
Authors: Park Sohl , Yun Ju Hyun , Go Yu Jin , Jung Soo Yeon
Published: June 2022

Sebaceous carcinoma is extremely rare in the parotid gland. Recently, we experienced a case of carcinoma with sebaceous differentiation arising from the parotid gland in patient who was diagnosed as parotid adenoma carcinoma and underwent total parotidectomy.
A 73-year-old male visited our department for the evaluation of 3-month history of infra-auricular mass combined with pain. Radiologic finding showed lobulated enhancing and solid mass with calcification in the right parotid gland. Initially, total parotidectomy with supraomohyoid neck dissection was performed. Pathological findings showed capsulated whitish mass with hemorrhage and cystic degeneration. Immunohistochemically, CK7, CK5/6, p63 were positive and CEA was negative. The intra-operative frozen section diagnosis was mucoepidermoid carcinoma. The permanent diagnosis was changed to adenocarcinoma, NOS(not otherwise specified). Fourteen months later, the newly developed mass was noticed on the operation bed. The mass was clinically diagnosed as recurred adenocarcinoma. Revision parotidectomy was performed and pathological findings revealed that the tumor was newly developed sebaceous carcinoma. We report a case of carcinoma with sebaceous differentiation in parotid gland with a review of literature.
Case Report: Intracapsular Carcinoma Ex Pleomorphic Adenoma of Parotid Gland
Authors: Lee Seungyeol , Son Hwangkyu , Park Ho Sub , Song Chang Myeon
Published: June 2022

Among a variety of malignant types for parotid gland tumors, intracapsular carcinoma ex pleomorphic adenoma which is classified as a non-invasive tumor has been reported rarely. We report a case of a 69-years old patient, who presented with a left parotid mass that was detected 30 years ago. Fine needle aspiration biopsy result of the mass was “suggestive of pleomorphic adenoma”. Superficial partial parotidectomy was performed for the mass and the permanent pathologic finding was “intracapsular carcinoma ex pleomorphic adenoma” which was a salivary ductal carcinoma with well-preserved myoepithelial cells surrounding the malignant epithelial cell clusters. Surgical resection is the main treatment modality for the treatment of intracapsular carcinoma ex pleomorphic adenoma. Herein, we present the case with a review of literature.
A Case of Mucosa-Associated Lymphoid Tissue (MALT) Lymphoma in Buccal Mucosa
Authors: Lee Hyeon A , Myung Jae Kyung , Tae Kyung
Published: June 2022

Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) is a lowgrade B-cell lymphoma that typically follows an indolent clinical course. It occurs in a variety of mucosal linings extranodal tissue, most commonly in the stomach. Other commonly involved sites include other parts of the gastrointestinal tract, thyroid, salivary gland, lung, lacrimal gland, synovium, dura mater, breast, skin, and eyes. It occurs very rarely in the buccal mucosa. A 50-year-old man came to the clinic while presenting a 5-month history of rightsided buccal mass. The incisional biopsy did not confirm the diagnosis of the lesion. He underwent complete excision of buccal mass for the diagnosis and treatment. The final pathology confirmed MALT lymphoma immunohistochemically. After surgery, he received radiotherapy with 30.6 Gy. There is no recurrence for 8 months after treatment. Herein we report a rare case of buccal MALT lymphoma with a review of the literature.
A Case of Postoperative Silicone Magnet Compression Treatment of Pseudocyst in the Ear
Authors: Seol Seong Hoon , Chung Chan Min , Park Myong Chul
Published: June 2022

Endochondral pseudocyst of the ear is a rare, benign, non-inflammatory cystic disease. It is known that there are a variety of treatment methods for pseudocyst, which is mainly common in the scaphoid or triangular fossa of the ear. Pseudocyst formation is prevalent in the residual cavity of the ear. So, to prevent a recurrence, a surgical approach is also required, but management through compression is necessary after surgery. Applying a cube magnet to the lesion to press provides patient convenience and facilitates continuous management.