bluuebunny/crossref_metadata_2025 huggingface dataset:
Coral-Like Hierarchical Nanostructured ZnMn2O4/Mn2O3 Composites Synthesized by Zinc-Absent Method as a High-Performance Cathode Material for Aqueous Zinc-Ion Batteries
Authors: Cai Kexing , Luo Shao-Hua , Cong Jun , Li Kun , Yan Sheng-xue , Hou Peng-qing , Wang Qing , Zhang Yahui , Liu Xin
Published: May 2022

As one of the multivalent ion batteries, the zinc ion battery has the advantages of high-volume energy density and good safety. In this paper, coral-like and nanoparticle crosslinking hierarchical nanostructured ZnMn2O4/Mn2O3 composites were successfully synthesized as cathode materials for zinc ion batteries by a simple sol-gel combined with the zinc-absent method. ZnMn2O4/Mn2O3 composites with good properties were prepared when the zinc content was 10%. The prepared ZnMn2O4/Mn2O3 composites have the morphology of coral-like and nanoparticle crosslinking and uniform particle size distribution. Compared with pure ZnMn2O4 and Mn2O3, the composites show excellent electrochemical properties. Using 0.5 M Zn(CF3SO3)2-AN/H2O (8:2) as the electrolyte, the first discharge capacity of the material can reach 170.7 mAh·g−1 at 0.05 C. After 150 cycles, the discharge capacity remained 109 mAh·g−1. The kinetic characteristic of the electrode was studied by the galvanostatic intermittent titration technique, and the electrochemical reaction mechanism was studied by ex situ XRD. It was found that the two-phase recombination improved the diffusion rate of Zn2+. In the field of aqueous zinc ion batteries, an effective modification idea is provided for the research of spinel ZnMn2O4 cathode material with low specific capacity.
The Modified Glassy Carbon Electrode by MWCNTs-PLL to Detect Both Paracetamol and Ibuprofen in Human Biological Fluid
Authors: Dao Anh Quang , Nguyen Do Mai , Toan Tran Thanh Tam
Published: May 2022

The MWCNTs-PLL material was effectively synthesized in this study. The UV–vis spectrum and FT-IR spectroscopy are used to determine the structure of nanoparticles. The electrochemical characteristics of glassy carbon electrodes (GCE) were examined after the MWCNTs-PLL material with nanosized particles was dropped onto its surface to create MWCNTs-PLL/GCE. Furthermore, employing electrodes, PAR and IBU were examined via applying CV and DP-ASV techniques. In comparison to employing the bare GCE, the modified MWCNTs-PLL/GCE electrode showed good responsiveness toward PAR and IBU applying the DP-ASV technique, with LODs were 0.40 for PAR, 0.34 μM for IBU. The linear concentrations ranged from 1.0 to 210 μM. These factors like Na+, SO4
2−, CO3
2−, K+, Ca2+, Cl−, Mg2+, NH4
+, NO3
− ions, uric acid, oxalate and AA, did not interfere during the modified electrode’s operation. Within this paper, it is worth emphasizing that these analytical processes for the PAR and IBU in practical sample solutions are more dependable than the HPLC tool. Additionally, this work would be considered the state-of-the-art study for both using MWCNTs-PLL to simultaneously determine PAR and IBU, and employing successfully the cheap, fast, reliable method.
Analysis of Accuracy Rate of Distributed Virtual Reality Face Recognition Based on Personal Intelligent Terminal
Authors: Hu Muhua
Published: May 2022

Due to the fact that problem occurs to the traditional algorithm in the internal change process of the sample set, this paper proposes a distributed virtual reality face recognition algorithm based on the personal intelligent terminal. By the utilization of the face image library with multiple description functions through expansion, the pixel intensity of the face image has data information, the original face image can be used to generate a face image with higher intensity pixels, and the mirror image can increase the detailed data information of the image. By effectively combining source domain images with initialization images, a scalable image set can be generated. According to parameter-free modeling, the image can be extended as a personal intelligent terminal. The test sample images of the same category and different source domains can form an image set and finally use the residual discriminant function to complete the face recognition. Finally, the results of the experimental analysis show that the distributed virtual reality face recognition accuracy analysis method proposed in this paper can not only build a face image database with multiple reconstruction functions but also effectively use the correlation within the face samples to improve the accuracy of face recognition and implement face recognition. Compared with other facial recognition algorithms, this algorithm has higher recognition accuracy and faster recognition speed.
Characteristics and Clinical Significance of Intestinal Microbiota in Patients with Chronic Hepatitis B Cirrhosis and Type 2 Diabetes Mellitus
Authors: Sun Xiu , Chi Xin , Zhao Yingying , Liu Shunai , Xing Huichun
Published: May 2022

Background. Chronic hepatitis B cirrhosis is often accompanied by glucose metabolism disorder, and intestinal microbiota was closely related to both cirrhosis and diabetes. There are few studies on the role of intestinal microbiota in hepatitis B liver cirrhosis and diabetes mellitus (LCDM). The purpose of this study was to investigate the characteristics of intestinal microbiota in patients with LCDM and to evaluate the relationship between the severity of intestinal microbiota imbalance and clinical significance. Methods. A case-controlled study was conducted. People who met the inclusion and exclusion criteria of chronic HBV-related liver cirrhosis (LC), LCDM, and healthy controls (HC) were enrolled in, and their fecal and blood samples were collected. The V3-V4 region of 16s rDNA gene of fecal microbiota was sequenced; the bioinformatics analysis including α-diversity, β-diversity, and linear discriminant analysis (LDA) effect size (LEfSe) was performed; and the correlation between bacteria and clinical indexes was analyzed. Results. A total of 70 participants completed fecal and blood tests, including 20 HC, 20 LCDM, and 30 LC. The α diversity of intestinal microbiota in the LCDM decreased than that in the HC. The abundance of Proteobacteria, Streptococcus, Escherichia-Shigella, and Lactobacillus increased, while the abundance of Bacteroidota, Bacteroides, Prevotella, Faecalibacterium, and Lachnospira decreased in the LCDM compared with the HC. The abundance of Lactobacillus, Roseburia, and Veillonella and the degree of hepatitis B cirrhosis dysbiosis indicator (HBCDI) increased in the LCDM than in the LC. The abundance of Escherichia-Shigella, Veillonella, and Lactobacillus positively correlated with liver injury and fasting blood glucose (FBG) level. The abundance of Escherichia-Shigella, Veillonella, Streptococcus, and Lactobacillus increased more significantly when FBG and glycosylated hemoglobin level increased. Conclusion. Intestinal microbiota of patients with LCDM was significantly disordered, and the degree was more serious than that cirrhosis patients without diabetes.
On Statistical Properties of a New Bivariate Modified Lindley Distribution with an Application to Financial Data
Authors: Elhassanein Ahmed
Published: May 2022

There is an increasing interest in expanding the one‐parameter Lindley distribution to two‐parameter, three‐parameter, and five‐parameter. The univariate one‐parameter Lindley distribution is still one of the most applicable distributions in data analysis especially in lifetime data. Modeling dependent random quantities required bivariate parametric probability distributions. This study presents a new bivariate three‐parameter probability distribution called bivariate modified Lindley distribution. The one‐parameter modified Lindley distribution is used as a base line to construct the new model. Its statistical properties including cumulative function, density function, marginals, moments, conditional distributions, and copula are discussed. Simulation is constructed to declare theoretical properties, to show the flexibility of the new model and to investigate the goodness of fit. Two sets of real data, financial data and UEFA Champion’s League data, are used to show the applicability of the proposed model for different types of data.
Efficiency Analysis of Sports Equipment Batch Management Based on Antimetal RFID Tag
Authors: Huang Zhongwei , Sun Xuebin
Published: May 2022

Based on the antimetal RFID tag model, a sports equipment batch management system is established. The establishment process of the model and system is discussed in detail, and the principle of metal-resistant RFID tag is revealed. Then, the antimetal RFID tag sports equipment batch management system is applied to colleges, middle schools, and primary schools, and the use of teachers and students on the efficiency of sports equipment batch management is studied, highlighting the advantages of the management system. In general, the antimetal RFID tag sports equipment batch management system has timeliness, universality, and reliability. It can adapt to the sports equipment management of different schools, improve its management efficiency, and play a positive role in the development of modern school sports.
Characteristics of Fragments Produced by Ternary Fission in Intermediate Energy
Authors: Li Xian , Wang Chengqian , Xu Yaohui
Published: May 2022

The characteristics of fragments produced in the ternary fissions have been researched by using the improved quantum molecular dynamics model in heavy 197Au+197Au at 15 MeV/nucleon. The physical quantities of Z, n/z, θ, ptrans/plong about the nuclear fragments have strong dependencies on the impact parameters, and their curves are systematically drawn. By the study of these theoretical results above, we have concluded that there is a cut-off point at b =6 fm, which divides the impact parameters into two regions: the central or semi-peripheral and peripheral regions, and the ternary breakup mechanisms should be very different at these two impact parameter regions. Further research has showed that the regional property of n/z is related to the isospin symmetry of nuclear products, and the conclusion reflects the properties of nuclear fragments may be an observable probe into the nucleon interactions during heavy ion collisions.
Survival Prediction in Patients with Hypertensive Chronic Kidney Disease in Intensive Care Unit: A Retrospective Analysis Based on the MIMIC-III Database
Authors: Xia Zuoxun , Xu Peng , Xiong Ye , Lai Yunbo , Huang Zhaohui
Published: May 2022

Objective. Disease prediction is crucial to treatment success. The aim of this study was to accurately and explicably predict, based on the first laboratory measurements, medications, and demographic information, the risk of death in patients with hypertensive chronic kidney disease within 1 and 3 years after admission to the Intensive Care Unit (ICU). Methods. Patients with hypertensive chronic kidney disease who had been registered in the Medical Information Mart for Intensive Care (MIMIC-III) database of critical care medicine were set as the subject of study, which was randomly divided into a training set and a validation set in a ratio of 7 : 3. Univariate Cox regression analysis and stepwise Cox regression analysis were applied in the training set to identify the predictive factors of prognosis of patients with hypertensive chronic kidney disease in ICU, and the predictive nomogram based on Cox regression model was constructed. We internally validated the model in the training set and externally validated that in the validation model. The efficacy was assessed primarily through area under the receiver operating characteristic (ROC) curve, clinical decision curves, and calibration curves. Results. A total of 1762 patients with hypertensive chronic kidney disease were finally included. During the 3-year follow-up, 667 patients (37.85%) died, with a median follow-up time of 220 days (1-1090). The data set were randomly divided into a training set (

n
=
1231

) and a validation set (

n
=
531

). It was identified in the training set that insurance, albumin, alkaline phosphatase, the mean corpuscular hemoglobin concentration, mean corpuscular volume, history of coronary angiogram, hyperlipemia, medication of digoxin, acute renal failure, and history of renal surgery were the most relevant features. Taking 1 year and 3 years as the cut-off points, the AUC of participants were 0.736 and 0.744, respectively, in the internal validation and were 0.775 and 0.769, respectively, in the external validation, suggesting that the model is of favorable predictive efficacy. Conclusion. We trained and validated a model using data from a large multicenter cohort, which has considerable predictive performance on an individual scale and could be used to improve treatment strategies.
First-Time Diagnosis and Ultrasound Features of Extranodal Lymphoma in Children
Authors: Li Na , Li Min , Zhang Qian , Wei Jingli , Liu Bailing
Published: May 2022

Objective.To assess the diagnostic value of ultrasound for extranodal lymphoma in children. Methods. In this retrospective study, the first diagnostic clinical manifestation, ultrasound sonograms, and puncture pathology of 40 cases of pediatric lymphoma treated in Xi’an Children’s Hospital from August 2018 to March 2020 were analyzed. Results. The first diagnostic clinical manifestation varied from jaundice to gastrointestinal, motor, neurological, respiratory, circulatory skin, and soft tissue multisystem disorders. The intranodal ultrasound results showed abnormally enlarged lymph nodes with extranodal involvement of the liver, pancreas, spleen, kidney, ovaries, and mediastinum as hypoechoic masses with multiple plasma cavity effusions, and color Doppler flow imaging (CDFI) results showed abundant blood flow signals in the lesions. The pathological diagnosis by ultrasound-guided puncture was Hodgkin lymphoma, non-Hodgkin lymphoma, and multiple subtypes. Conclusion. Routine ultrasound can provide an imaging basis for early identification and differential diagnosis of lymphoma, and ultrasound-guided puncture biopsy is simple, minimally invasive, and histopathological-based.
Effect of HLA-G5 Immune Checkpoint Molecule on the Expression of ILT-2, CD27, and CD38 in Splenic B cells
Authors: Rohn Hana , Lang Cordula , Schramm Sabine , Heinemann Falko M. , Trilling Mirko , Gäckler Anja , Witzke Oliver , Horn Peter A. , Rebmann Vera
Published: May 2022

The human leukocyte antigen G (HLA-G) is an immune checkpoint molecule with a complex network of interactions with several inhibitory receptors. Although the effect of HLA-G on T cells and NK cells is well studied, the effect of HLA-G on B cells is still largely elusive. B cells are of particular interest in the context of the HLA-G-ILT-2 interaction because the ILT-2 receptor is constitutively expressed on most B cells, whereas it is only present on some subsets of T and NK cells. To characterize the effect of HLA-G5 molecules on B cells, we studied splenic B cells derived from cytomegalovirus (CMV) sero-positive donors after CMV stimulation with antigens in the presence and absence of soluble HLA-G5. In the presence of HLA-G5, increased expression of the ITIM-bearing Ig-like transcript (ILT-2) was observed on B cells, but its expression was not affected by stimulation with CMV antigens. Moreover, it became evident that HLA-G5 exposure resulted in a decreased expression of CD27 and CD38 and, accordingly, in lower proportions of CD19+CD27+CD38+ and higher proportions of CD19+CD27-CD38- B cells. Taken together, our in vitro findings demonstrate that soluble HLA-G5 suppresses markers of B cell activation, suggesting that HLA-G5 has an impact on splenic B cell differentiation and activation. Based on these results, further investigation regarding the role of HLA-G as a prognostic factor and a potential therapeutic agent with respect to B cell function appears reasonable.
A Substance P (SP)/Neurokinin-1 Receptor Axis Promotes Perineural Invasion of Pancreatic Cancer and Is Affected by lncRNA LOC389641
Authors: Ji Tengfei , Ma Keqiang , Wu Hongsheng , Cao Tiansheng
Published: May 2022

Perineural invasion (PNI) is considered to be a main reason for the poor prognosis of pancreatic cancer. In the present study, we analyzed the roles of substance P (SP)/neurokinin-1 receptor (NK-1R) and lncRNA LOC389641 in pancreatic cancer PNI. Pancreatic cancer cell lines BxPC-3 and MIAPaCa-2 were cocultured with SH-SY5Y cells and then stimulated with SP to simulate the in vivo influence of ganglia on pancreatic cancer. The BxPC-3 and MIAPaCa-2 cells were transfected with a neurokinin-1 receptor (NK-1R) overexpression vector, NK-1R silencing vector, LOC389641 overexpression vector, or LOC389641 silencing vector, respectively. The proliferative abilities of BxPC-3 and MIAPaCa-2 cells were assessed using the cell counting kit-8 and 5-ethynyl-2′-deoxyuridine (EdU) assays. Wound-healing and Transwell assays were performed to determine the migration and invasion abilities of the cells. When SP was added to the coculture system, it positively regulated cancer cell proliferation, migration, and PNI and significantly activated the NK-1R/Akt/NF-κB signaling pathway. Incubation with 100 nmol/L SP for 24 h was selected as the optimal condition for treatment. The activated NK-1R positively regulated the proliferation, migration, and invasion of pancreatic cancer cells. However, the levels of lncRNA LOC389641 and tumor necrosis factor receptor SF10A (TNFRSF10A) mRNA in BxPC-3 and MIAPaCa-2 cells were not affected by SP treatment. Overexpression or silencing of LOC389641 changed the effect of SP stimulation on pancreatic cancer PNI. When taken together, these results revealed that SP/NK-1R and LOC389641 promoted the progression of pancreatic cancer PNI. Moreover, we found that pancreatic cancer PNI promoted by the SP/NK-1R axis could be blocked by the TNFRSF10A/NF-κB pathway mediated by LOC389641.
Long Noncoding RNA HCP5 Contributes to Nasopharyngeal Carcinoma Progression by Targeting MicroRNA-128-3p
Authors: Miao Gangyong , Liu Bin , Ling Keji , Peng Tao , Zhou En , Xie Sijun , Tan Zhiqiang
Published: May 2022

Aim. To determine the role and underlying mechanism of lncRNA HCP5 in nasopharyngeal carcinoma (NPC). Method. The expression of HCP5 and miR-128-3p was assessed by qRT-PCR. CCK-8, EdU staining, and transwell were performed to determine cell progression. A nude mouse xenograft tumor model was carried out to detect the role of HCP5 in vivo. The luciferase assay was performed to confirm the function between lncRNA HCP5 and miR-128-3p. Results. The increased level of HCP5 was observed in NPC tissues. Silencing of HCP5 prevented tumor progression in vitro and in vivo. The luciferase assay verified that HCP5 could bind with miR-128-3p. Furthermore, forced expression of miR-128-3p could prevent the function of HCP5 on NPC cells. Conclusion. lncRNA HCP5 could regulate NPC cell progression via sponging miR-128-3p, which might serve as a potential therapy target of NPC.
L-Borneol 7-O-[β-D-Apiofuranosyl-(1
→
6)]-β-D-Glucopyranoside Alleviates Myocardial Ischemia-Reperfusion Injury in Rats and Hypoxic/Reoxygenated Injured Myocardial Cells via Regulating the PI3K/AKT/mTOR Signaling Pathway
Authors: Tong Ziyi , Li Gaowen , Su Chengxiao , Zhou Liyan , Zhang Ling , Chen Qun , Xia Qing
Published: May 2022

Ischemia/reperfusion (I/R) is a primary cause of morbidity and mortality in acute myocardial infarction (AMI). L-Borneol 7-O-[β-D-apiofuranosyl-(1→6)]-β-D-glucopyranoside (LBAG), extracted from the Radix Ophiopogonis, is the main bioactive component that may be exerting cardiovascular protection in AMI. The purpose was to examine the effects of LBAG on myocardial I/R injury (MIRI) in rats and H9c2 cells treated with hypoxia/reoxygenation (H/R). MIRI was induced through the combination of ischemia with reperfusion for 30 min and 24 h, respectively. LBAG was administered 7 days before vascular ligation. Myocardial function was detected by an electrocardiograph, histological, TTC, and TUNEL staining analyses. The influences of LBAG on the content concentration of cardiac enzymes in the serum were measured by ELISA. Moreover, H9c2 cells were exposed to LBAG or combined with AKT inhibitor (perifosine) and then exposed to H/R for simulating the cardiac injury process. Afterward, cell viability, LDH, CD-KM release, apoptosis, and autophagy were evaluated by CCK-8 and ELISA assays, flow cytometry, TUNEL, and immunofluorescence staining, respectively. Additionally, the proteins of apoptosis, autophagy, and PI3K/mTOR pathway were determined by western blotting. In I/R rats, LBAG pretreatment significantly ameliorated cardiac function, as illustrated by reducing the infarct size, myocardial autophagy, and apoptosis levels. In H/R-induced H9c2 cells, LBAG pretreatment significantly decreased cell apoptosis, LC3 II/I, and Beclin 1 levels, elevated the Bcl-2 levels, attenuated LDH, and CD-KM production. Moreover, LBAG pretreatment markedly increased the PI3K/mTOR pathway activation, and the protective influences of LBAG were partly abolished with the AKT inhibitor perifosine treatment. These findings demonstrated the protective functions of LBAG on I/R by regulating apoptosis and autophagy in vitro and in vivo by activating the PI3K/mTOR pathway.
Capsaicin Alleviates Vascular Endothelial Dysfunction and Cardiomyopathy via TRPV1/eNOS Pathway in Diabetic Rats
Authors: Wang Qiuyue , Zhang Caihui , Yang Chen , Sun Yue , Chen Keyang , Lu Yao
Published: May 2022

Background. Endothelial dysfunction and cardiomyopathy are considered to be important vascular complications associated with diabetes. This study was designed to investigate whether capsaicin (CAP), a selective TRPV1 agonist, could prevent diabetes-induced endothelial dysfunction and cardiomyopathy. Methods. Male Sprague Dawley rats aged 8 weeks were injected intraperitoneally with streptozotocin (STZ, 50 mg/kg) to establish the diabetes model. The diabetic rats were randomly divided into the untreated diabetes group (DM, 10/group) and diabetes plus CAP treatment group (DM+CAP, 10/group); meanwhile, the nondiabetic healthy rats were used as normal controls (10/group). DM+CAP group were treated with CAP by gavage for 8 weeks. The cultured mouse vascular endothelial cells were exposed to different concentrations of glucose in the presence or absence of CAP treatment. The TRPV1 inhibitor capsazepine (CPZ) and eNOS inhibitor L-NAME were used in vivo and in vitro experiment. Results. CAP treatment significantly decreased the serum total cholesterol (TC) and total triglyceride (TG) and ameliorated the pathogenesis and fibrosis in the heart, while did not significantly improve plasma glucose level and the body weights of diabetic rats. In addition, CAP enhanced the expression of TRPV1 and eNOS in the heart and normalized the vascular permeability under diabetic state. Similarly, CAP treatment also increased nitric oxide and reduced reactive oxygen species. The same results were observed in cultured mouse vascular endothelial cells by CAP treatment. These beneficial effects of CAP were abolished by either CPZ or L-NAME. Conclusions. CAP might protect against hyperglycemia-induced endothelial dysfunction and diabetic cardiomyopathy through TRPV1/eNOS pathway.
Orthodontic Management of Skeletal Class II Malocclusion with the Invisalign Mandibular Advancement Feature Appliance: A Case Report and Review of the Literature
Authors: Koukou Melina , Damanakis George , Tsolakis Apostolos I.
Published: May 2022

The treatment of Class II malocclusion due to mandibular retrognathia is one of the most common challenges met in orthodontic practice. When it comes to a growing patient, functional appliances are the optimal way to achieve growth modification by enhancing mandibular growth. Clear aligners have been part of the orthodontic treatment for several decades but until recently they were only used to correct mild malocclusions. In 2017, Align Technology introduced the Invisalign with Mandibular Advancement Feature (IMAF) which replicates the action of functional appliances. As this device is new to clinical practice, there is limited literature on its clinical efficiency. This case report describes the orthodontic management of a 12-year-old male patient having skeletal Class II malocclusion due to mandibular retrognathia. As the patient was experiencing active growth, the IMAF appliance was chosen for his treatment. The IMAF appliance appears to be successful in the treatment of Class II malocclusion with mandibular retrognathism in a growing patient. As with all functional appliances, the correction of the malocclusion is a result of both skeletal and dental effects and the IMAF presents the advantage of producing less proclination of the lower incisors compared to other functional appliances.
Repair and Reinforcement of Concrete Bridges Based on Cement-Based Composite Materials
Authors: Huang Ning , Ruan Zhigang , Zhang Li , Wang Wei , Wang Hongyin
Published: May 2022

At present, epoxy resin is almost used as a binder in bridge reinforcement, but there are some drawbacks due to the huge difference in mechanical properties and temperature incompatibility between it and concrete. Cement-based composites show obvious multi-crack cracking characteristics and strain hardening behavior in the process of stress and have better mechanical properties and durability than traditional cement materials, and have been successfully used in many practical projects. In this paper, the cement-based composite material is used as the concrete beam member of the bridge deck continuous material, and its mechanical properties are characterized and compared with the traditional cement slurry material properties. The results show that the ductility of cement-based composites is significantly affected by the fiber content. When the volume ratio is less than or equal to the critical volume rate, the ductility increases gradually with the increase of fiber content. The maximum value of the plastic strain at the initial crack is greater than that of the concrete beam member using cement mortar as the bridge deck continuous material, and the crack resistance of the bridge deck continuous structure is significantly improved. The addition of cement-based composites can significantly increase the cracking load of the test beams. Under the same load conditions, the crack resistance of the continuous structure of the cement-based composite bridge deck is better, and local cracking is less likely to occur.
Banana Peels: A Waste Treasure for Human Being
Authors: Hikal Wafaa M. , Said-Al Ahl Hussein A. H. , Bratovcic Amra , Tkachenko Kirill G. , Sharifi-Rad Javad , Kačániová Miroslava , Elhourri Mohammed , Atanassova Maria
Published: May 2022

In recent years, scientists’ interest in agricultural waste has increased, and the waste has become attractive to explore and benefit from, rather than being neglected waste. Banana peels have attracted the attention of researchers due to their bioactive chemical components, so we focused on this review article on the antioxidant and antimicrobial activities of banana peels that can be used as good sources of natural antioxidants and for pharmaceutical purposes in treating various diseases. Banana is an edible fruit belonging to the genus Musa (Musaceae), cultivated in tropical and subtropical regions. Banana peels are used as supplementary feed for livestock in their cultivation areas. Its massive by-products are an excellent source of high-value raw materials for other industries by recycling agricultural waste. Hence, the goal is to use banana by-products in various food and nonfood applications and sources of natural bioactive compounds. It can be concluded that banana peel can be successfully used in food, pharmaceutical, and other industries. Therefore, banana residues may provide new avenues and research areas for the future.
lncRNA LUCAT1/ELAVL1/LIN28B/SOX2 Positive Feedback Loop Promotes Cell Stemness in Triple-Negative Breast Cancer
Authors: Xia Li , Wang Hao
Published: May 2022

Background. Triple-negative breast cancer (TNBC), as a subtype of breast cancer (BC), features an aggressive nature. Long noncoding RNAs (lncRNAs) are proved to get involved in the processes of cancers. lncRNA lung cancer associated transcript 1 (LUCAT1) has been reported in multiple cancers. The role of LUCAT1 in TNBC and its latent regulatory mechanism were investigated. Methods. RT-qPCR was performed to examine LUCAT1 expression. Functional experiments were implemented to disclose the role of LUCAT1 in TNBC. The underlying regulatory mechanism of LUCAT1 in TNBC was explored by chromatin immunoprecipitation (ChIP), RNA-binding protein immunoprecipitation (RIP), luciferase reporter, and RNA pull-down assays. Results. LUCAT1 is significantly overexpressed in TNBC cells. LUCAT1 interference impedes cell stemness in TNBC cells. SRY-box transcription factor 2 (SOX2) is an active transcription factor of LUCAT1. LUCAT1 recruits ELAV-like RNA binding protein 1 (ELAVL1) protein to stabilize lin-28 homolog B (LIN28B) mRNA, thereby further modulating SOX2 expression, which forms a positive feedback loop. Conclusion. The lncRNA LUCAT1/ELAVL1/LIN28B/SOX2 positive feedback loop promotes cell stemness in TNBC. The exploration of the mechanisms underlying TNBC stemness might be beneficial to TNBC treatment.
Fixed-Point Results Related to b-Intuitionistic Fuzzy Metric Space
Authors: Altanji Mohamed , Santhi Annamalai , Govindan Vediyappan , Santra Shyam Sundar , Noeiaghdam Samad
Published: May 2022

In this study, we contribute to the terminological debate about various fixed-point results’ use of the term intuitionistic fuzzy b-metric space in defining the structure based on fuzzy sets. As a predominant result, we give an adequate condition for a sequence to be Cauchy in the intuitionistic fuzzy b-metric space. Subsequently, we simplify the proofs of manifold fixed-point theorems in the intuitionistic fuzzy b-metric spaces under the prominent contraction conditions. Also, we give a satisfactory condition for a solution to Cauchy in the intuitionistic fuzzy b-metric spaces.
Long-Term Outcomes among Adolescent and Young Adult Survivors of Acute Leukemia: A Surveillance, Epidemiology, and End Results Analysis
Authors: Berkman Amy M. , Andersen Clark R. , Cuglievan Branko , McCall David C. , Lupo Philip J. , Parsons Susan K. , DiNardo Courtney D. , Short Nicholas J. , Jain Nitin , Kadia Tapan M. , Livingston J.A. , Roth Michael E.
Published: May 2022

Background:

There is a growing population of adolescent and young adult (AYA, age 15–39 years) acute leukemia survivors in whom long-term mortality outcomes are largely unknown.

Methods:

The current study utilized the Surveillance, Epidemiology, and End Results (SEER) registry to assess long-term outcomes of AYA acute leukemia 5-year survivors. The impact of diagnosis age, sex, race/ethnicity, socioeconomic status, and decade of diagnosis on long-term survival were assessed utilizing an accelerated failure time model.

Results:

A total of 1,938 AYA acute lymphoblastic leukemia (ALL) and 2,350 AYA acute myeloid leukemia (AML) survivors diagnosed between 1980 and 2009 were included with a median follow-up of 12.3 and 12.7 years, respectively. Ten-year survival for ALL and AML survivors was 87% and 89%, respectively, and 99% for the general population. Survival for AYA leukemia survivors remained below that of the age-adjusted general population at up to 30 years of follow-up. Primary cancer mortality was the most common cause of death in early survivorship with noncancer causes of death becoming more prevalent in later decades of follow-up. Male AML survivors had significantly worse survival than females (survival time ratio: 0.61, 95% confidence interval: 0.45–0.82).

Conclusions:

AYA leukemia survivors have higher mortality rates than the general population that persist for decades after diagnosis.

Impact:

While there have been improvements in late mortality, long-term survival for AYA leukemia survivors remains below that of the general population. Studies investigating risk factors for mortality and disparities in late effects among long-term AYA leukemia survivors are needed.
Epigenetic Repression of STING by MYC Promotes Immune Evasion and Resistance to Immune Checkpoint Inhibitors in Triple-Negative Breast Cancer
Authors: Lee Kyung-min , Lin Chang-Ching , Servetto Alberto , Bae Joonbeom , Kandagatla Vishal , Ye Dan , Kim GunMin , Sudhan Dhivya R. , Mendiratta Saurabh , González Ericsson Paula I. , Balko Justin M. , Lee Jeon , Barnes Spencer , Malladi Venkat S. , Tabrizi Siamak , Reddy Sangeetha M. , Yum Seoyun , Chang Ching-Wei , Hutchinson Katherine E. , Yost Susan E. , Yuan Yuan , Chen Zhijian J. , Fu Yang-Xin , Hanker Ariella B. , Arteaga Carlos L.
Published: May 2022

The MYC oncogene is frequently amplified in triple-negative breast cancer (TNBC). Here, we show that MYC suppression induces immune-related hallmark gene set expression and tumor-infiltrating T cells in MYC-hyperactivated TNBCs. Mechanistically, MYC repressed stimulator of interferon genes (STING) expression via direct binding to the STING1 enhancer region, resulting in downregulation of the T-cell chemokines CCL5, CXCL10, and CXCL11. In primary and metastatic TNBC cohorts, tumors with high MYC expression or activity exhibited low STING expression. Using a CRISPR-mediated enhancer perturbation approach, we demonstrated that MYC-driven immune evasion is mediated by STING repression. STING repression induced resistance to PD-L1 blockade in mouse models of TNBC. Finally, a small-molecule inhibitor of MYC combined with PD-L1 blockade elicited a durable response in immune-cold TNBC with high MYC expression, suggesting a strategy to restore PD-L1 inhibitor sensitivity in MYC-overexpressing TNBC.
The Correlation between Ferroptosis and m6A Methylation in Patients with Acute Kidney Injury
Authors: Ni Lihua , Bai Rui , Zhou Qiuyuan , Yuan Cheng , Zhou Le-Ting , Wu Xiaoyan
Published: May 2022

Objective: The present research analyzed the correlation between N6-methyladenosine (m6A) methylation and ferroptosis associated genes (FAGs) in acute kidney injury (AKI) patients. Methods: Bioinformatics analysis of microarray profiles (GSE30718) was performed to select differential expression genes (DEGs). FAGs are derived from systematic analysis of the aberrances and functional implications. The m6A methylation related genes were derived from the molecular characterization and clinical significance of m6A modulators. The multi-gene correlation of ferroptosis and M6A methylation modification was displayed. Then, the CIBERSORT algorithm was used to analyze the proportions of 22 immune cell infiltration. Results: In total, 349 DEGs were extracted between the AKI and control samples, among which 172 genes were upregulated and 177 were downregulated. FAGs (SLC1A5, CARS, SAT1, ACSL4, NFE2L2, TFRC, and MT1G) and m6A methylation related genes (YTHDF3, WTAP, and IGF2BP3) were significantly increased in AKI patients (p < 0.05). FAGs (SAT1, ACSL4, and NFE2L2) were positively correlated with the expression level of m6A methylation genes (p < 0.05). NFE2L2 has high diagnostic value, and the level of NFE2L2 was negatively correlated with the degree of follicular helper T (TFH) cell infiltration. Conclusion: Our research could provide a new theoretical basis for the pathogenesis and immune mechanism of AKI.
O universo cultural da criança Guarani Mbya e a presença dos centros educacionais e culturais indígenas – Cecis – nas aldeias de São Paulo
Authors: Ferreira Edna , Godoy Marília Gomes Ghizzi
Published: May 2022

Os fundamentos religiosos da cultura Guarani Mbya e o espaço mítico religioso das kyringue (crianças) recriam-se nas propostas dos Centros de Educação e Cultura Indígenas (os CECIs), voltados para a educação indígena infantil, em 3 aldeias de São Paulo. Define-se uma proposta pedagógica mantida pela Prefeitura Municipal comprometida com os critérios legais de diversidade e de interculturalidade da educação indígena. O conteúdo dos projetos e das práticas educativas situam um comprometimento com a memória e a oralidade dos Guarani Mbya, onde os educadores indígenas representam suas próprias identidades estabelecendo um ambiente de auto afirmação étnica das kyringue diante dos conhecimentos e sabedorias antigas (arandu, yma guare), e do mundo vivido por seus ancestrais. As experiências do letramento e do mundo regido pela escrita (mbopara) são consideradas como importantes e necessários no convívio com o não-índio (o jurua) e com um meio de progresso para os aprendizes (nhembo’ea kuery).
Notas etnográficas sobre a religiosidade na escola
Authors: Valente Gabriela Abuhab , Setton Maria da Graça J.
Published: May 2022

Este artigo relata uma pesquisa que visa identificar e analisar a presença/ ausência da religiosidade na escola pública a partir da observação de estratégias e mecanismos de socialização difusos. Com base em estudos sobre religiosidade e socialização, verificou-se que a religiosidade está presente na escola de forma velada e naturalizada, mesmo quando não há oferecimento da disciplina Ensino Religioso. Para alcançar o escopo pretendido, procedeu-se um estudo de caso em uma escola pública municipal na cidade de Santo André/SP. Utilizou-se um arsenal de recursos metodológicos inspirados na metodologia etnográfica, dentre eles, a observação de campo, questionários e entrevistas semiestruturadas realizadas com professoras.
Relation of Household Income to Access and Adherence to Combination Sacubitril/Valsartan in Heart Failure: A Retrospective Analysis of Commercially Insured Patients
Authors: Johnson Amber E. , Swabe Gretchen M. , Addison Daniel , Essien Utibe R. , Breathett Khadijah , Brewer LaPrincess C. , Mazimba Sula , Mohammed Selma F. , Magnani Jared W.
Published: May 2022

Background:

Outcomes in heart failure with reduced ejection fraction (HFrEF) are influenced by access and adherence to guideline-directed medical therapy. Our objective was to study the association between annual household income and: (1) the odds of having a claim for sacubitril/valsartan among insured patients with HFrEF and (2) medication adherence (measured as the proportion of days covered). We hypothesized that lower annual household income is associated with decreased odds of having a claim for and adhering to sacubitril/valsartan.

Methods:

Using the Optum de-identified Clinformatics Data Mart, patients with HFrEF and ≥6 months of enrollment for follow-up (2016–2020) were included. Covariates included age, sex, race, ethnicity, educational attainment, US region, number of prescribed medications, and Elixhauser Comorbidity Index. Prescription for sacubitril/valsartan was defined by the presence of a claim within 6 months of HFrEF diagnosis. Adherence was defined as proportion of days covered ≥80%. We fit multivariable-adjusted logistic regression models and hierarchical logistic regression accounting for covariates.

Results:

Among 322 007 individuals with incident HFrEF, 135 282 had complete data for analysis. Of the patients eligible for sacubitril/valsartan, 4.7% (6372) had a claim within 6 months of HFrEF diagnosis. Following multivariable adjustment, individuals in the lowest annual income category (<$40 000) were significantly less likely (odds ratio, 0.83 [95% CI, 0.76–0.90]) to have a sacubitril/valsartan claim within 6 months of HFrEF diagnosis than those in the highest annual income category (≥$100 000). Annual income <$40 000 was associated with lower odds of proportion of days covered ≥80% compared with income ≥$100 000 (odds ratio, 0.70 [95% CI, 0.59–0.83]).

Conclusions:

Lower household income is associated with decreased likelihood of a sacubitril/valsartan claim and medication adherence within 6 months of HFrEF diagnosis, even after adjusting for sociodemographic and clinical factors. Future analyses are needed to identify additional social factors associated with delays in sacubitril/valsartan initiation and long-term adherence.
How Accurately Can Warm Rain Realistically Be Retrieved with Satellite Sensors? Part I: DSD Uncertainties
Authors: Schulte Richard M. , Kummerow Christian D. , Klepp Christian , Mace Gerald G.
Published: May 2022

A significant part of the uncertainty in satellite-based precipitation products stems from differing assumptions about drop size distributions (DSDs). Satellite radar-based retrieval algorithms rely on DSD assumptions that may be overly simplistic, whereas radiometers further struggle to distinguish cloud water from rain. We utilize the Ocean Rainfall and Ice-phase Precipitation Measurement Network (OceanRAIN), version 1.0, dataset to examine the impact of DSD variability on the ability of satellite measurements to accurately estimate rates of warm rainfall. We use the binned disdrometer counts and a simple model of the atmosphere to simulate observations for three satellite architectures. Two are similar to existing instrument combinations on the GPM Core Observatory and CloudSat, and the third is a theoretical triple-frequency radar–radiometer architecture. Using an optimal estimation framework, we find that the assumed DSD shape can have a large impact on retrieved rain rate. A three-parameter normalized gamma DSD model is sufficient for describing and retrieving the DSDs observed in the OceanRAIN dataset. Assuming simpler single-moment DSD models can lead to significant biases in retrieved rain rate, on the order of 100%. Differing DSD assumptions could thus plausibly explain a large portion of the disagreement in satellite-based precipitation estimates.
Interdecadal Changes of the South Asian High in CMIP5/6 and Projection of Its Future Changes
Authors: Zhang Dapeng , Huang Yanyan , Zhou Botao , Wang Huijun
Published: May 2022

Different from the significantly lifted geopotential height (H) that exhibits an enhanced South Asian high (SAH) under global warming, the eddy geopotential height (H′) can objectively reflect the decadal decline of SAH in the late 1970s. In this study, the capability of CMIP5/6 models for simulating the decadal decline of the SAH is assessed. Both the CMIP5 and CMIP6 models can yield better simulations of H′ compared to H simulations with smaller model spreads. CMIP6 models demonstrate better performances than CMIP5 in the simulation of variability and decadal changes of the SAH, which is attributed to the more reasonable simulations of upper-tropospheric eddy temperature (T′) by CMIP6. There is a large uncertainty of the SAH projection, since the SAH displays obviously different variations between SSP1-2.6 and SSP5-8.5. The internal climate variability may play a more important role in influencing the decadal variations of SAH compared to the anthropogenic forcing in the future twenty-first century, although both the external forcing and internal climate variability are important for the historical decadal changes of SAH.
E-wallets Influencing the Frugal Behavior of Consumers During COVID-19
Authors: Kiran Prabha , Arnav Anni
Published: May 2022

Several studies have been conducted to establish the relationships of different factors associated with the e-wallet usage in the recent times. But the effect of COVID-19 pandemic has impacted the e-wallet usage in transformed perspectives. In the crisis period, the acceptance of technology by the customers has definitely brought in the various dimensions to the business stakeholders to leverage on the benefits. It is very much evident for organizations to rework on their strategic viewpoints based on the trends and changes. The pandemic has brought in diverse experiences for the customers as well as businesses. The purpose of this research article leads to ascertaining the frugal consumers by analyzing their buying behavior and to further test the conceptual model of the impact of e-wallets on their buying behavior. This study uses the technology acceptance model (TAM) involving variables such as “Perceived Usefulness,” “Perceived Ease of Use,” “Perceived Risk,” “Trust,” “Social Influence,” “Promotional Benefits,” “Attitude,” “Behavior Intention to Buy Using E-wallets,” and the “Actual Usage of E-wallets.” Findings of this study portray the frugality of the consumers by the nature of their buying behavior, and they also show a strong relation between the frugal consumers and the positive or negative influence of e-wallets on their buying behavior. The results of the study can be applied by concerned organizations to improve their business model with respect to the variables mentioned.
Evaluation for internal consistency in the thermodynamic network involving fluorite, cryolite and villiaumite solubilities and aqueous species at 25°C and 1 bar
Authors: Nordstrom D. Kirk
Published: May 2022

Thermodynamic data are constrained by the interrelated thermodynamic equations in addition to the observational measurements and their uncertainties. The consequence is a network of thermodynamic properties that can be evaluated for their internal consistency. In this study, three fluoride minerals that can cause high fluoride concentrations in groundwaters are evaluated for their solubilities and their internal thermodynamic consistency with calorimetric, isopiestic and electrochemical measurements: fluorite, CaF2, cryolite, Na3AlF6, and villiaumite, NaF. This evaluation involves the three solids and 13 aqueous species, the free ions of Ca2+, Na+, Al3+ and F–, and the hydroxido and fluorido complexes of Al3+, and the CaF+ ion pair. For the fluorite–cryolite–villiaumite–aqueous species network, the number of components is minimal, and the solubility studies are mostly of high quality. Re-evaluations of original data using PHREEQC helps to broaden the quantitative evaluation of thermodynamic properties and to resolve apparent discrepancies. A check on this thermodynamic network shows that through a careful appraisal of the literature, a highly consistent set of values can be derived. The resultant infinite-dilution solubility-product constants at 25°C and 1 bar are: for fluorite solubility, logKsp = –10.57 ± 0.08; for cryolite solubility, logKsp = –33.9 ± 0.2; and for villiaumite solubility, logKsp = –0.4981 ± 0.003.
Tracking mineral evolution and element mobility during albitisation and subsequent kaolinisation of phyllite rocks: A case study from the Verrucano of Monti Pisani, Tuscany, Italy
Authors: D'Orazio Massimo , Fulignati Paolo , Gioncada Anna , Cavalcante Francesco
Published: May 2022

This work describes the first occurrence of albitite rocks in the Middle Triassic Verruca Formation, Monti Pisani, Northern Apennines, northern Tuscany, Italy. The albitite formed by Na-metasomatism of phyllites (‘potassic white mica' + quartz + ‘chlorite' + hematite + albite) in an amagmatic environment. The albitisation process took place after the Miocene main phases of Apenninic deformation and was followed by the formation of veins of Fe-carbonate + quartz. Hydrothermal alteration progressed with the ingression, possibly favoured by the increase of permeability due to albitisation, of a slightly acidic, oxidising, aqueous fluid that led to the pervasive kaolinisation of the albitite and to the complete transformation of the Fe-carbonate of the veins into Fe-hydroxides. This stage was followed by supergene alteration that led to the formation of a pervasive network of halloysite veinlets and colloform (P–Al–Si)-bearing Fe-hydroxides. Finally, the hydrothermally altered rock underwent a localised brittle fracturing without new minerals being formed. The prominent compositional changes occurring during this multi-stage hydrothermal process were the inversion of the Na2O/K2O ratio of the whole rock (from 0.07 in the pristine phyllite to up to 200 for the kaolinised albitite), the loss of Fe and Mg, and the enrichment of Sb. The MREE were partially lost, whereas LREE and HREE behaved conservatively. Though pervasive hydrothermal alteration occurrences are common in central-southern Tuscany, mostly related to the post-collisional extensional regime, lithospheric thinning and emplacement of magmatic bodies in the crust, the rare Monti Pisani kaolinised albitite described in this investigation expands the effects of post-collisional hydrothermal activity in Tuscany northwards, far from potential magmatic sources.