bluuebunny/crossref_metadata_2025 huggingface dataset:
Drug-Drug Interaction Potential of SH-1028, a Third-generation EGFR-TKI: In Vitro and Clinical Trials
Authors: Li Xiaoli , Liu Yuyan , Xu Yuanyuan , Ding Jiaxiang , Wang Ying , Shan Rongfang , Liu Yuanyuan , Liu Bingyan , Ding Yuzhou , Xie Jing , Zhou Huan , Wang Zhiqiang , Li Hongtao
Published: February 2023

SH-1028 is an irreversible third-generation EGFR tyrosine kinase inhibitor (EGFR-TKI) for the treatment of locally advanced or metastatic non-small cell lung cancer (NSCLC). Considering the possibility of combination therapy in patients with NSCLC, we investigated the drug-drug interaction (DDI) potential of SH-1028 both in vitro and in clinical trials. The in vitro studies were conducted to determine the potential of SH-1028 as a substrate, inducer, or inhibitor of cytochrome P450 (CYP) subtypes. A phase I drug-drug interaction study in healthy volunteers was performed to evaluate the impact of co-administering rifampicin (a strong CYP3A4 inducer) and itraconazole (a strong CYP3A4 inhibitor) on the pharmacokinetics of SH-1028. The in vitro experiments showed that SH-1028 was mainly metabolized by CYP3A4. The activities of CYP1A2, 2B6, 2C19, 2D6 and 3A4 enzymes were slightly inhibited in vitro with SH-1028. SH-1028 has no obvious induction effect on CYP1A2 and CYP2B6 activities, but has potential induction effect on CYP3A4 mRNA expression. However, SH-1028 may not induce or inhibit human CYPs significantly at the clinically expected dose (200 mg). The geometric mean ratios of pharmacokinetic parameters and their corresponding 90% confidence intervals for SH-1028 in combination and alone did not fall within the range of 80–125%. It is speculated that itraconazole and rifampicin affect the metabolism of SH-1028. In the clinical application of SH-1028, special attention should be paid to the interaction between SH-1028 and drugs or foods that affect the activity of CYP3A4. (Clinical trial registration number: CTR20210558)
Emergency Left Colectomy for Colon Cancer is Not Associated with Worst Oncologic Resection Quality Compared to Elective Surgery
Authors: Hazan Danny , Ishakov Arkadi , Levi Sammy , Shimonov Mordechai , Dayan Katia
Published: February 2023

Purpose:
Emergency colectomy of the left colon and sigma carries a higher risk of complication than elective colectomy. The aim of our study was to evaluate our results and to compare the outcome of these two operations.
Methods
Each patient included in this retrospective analysis underwent laparoscopic or open colectomy for malignant neoplasms with curative intent between 2011 and 2019. Surgical techniques were defined as emergency or elective depending on the timing of the operation, regardless of operational technique.
Results
A total of 242 patients were recruited, of which 125 had had emergency colectomies. Comparatively, 117 such patients underwent elective colectomies. There were no differences between the groups in factors such as age, gender, demographics and co-morbidities. The main reason for emergency operation included perforation in 105 patients (84%), and obstruction in 20 patients (16%).
No difference in the number of lymph nodes harvested (LNH) were found between the 2 groups (mean of 17 LNH, SD +-8). The length of stay (LOH) and time to first flatulence was different between the groups (8.72 +-4.17 days for the elective surgery vs. 19.28+-23.5 days for the emergency surgery for LOH, and 3+-1 days for the elective group Vs. 9+-11.5 days for the emergency group for time to first flatulence, p<0.001 in both).
The emergency group exhibited more serious complications (G III IV) than the elective group in the Clavien-Dindo classification. No difference was noted with regards to 30 days' survivals, length of operation and blood loss.
Conclusion
Our study suggests that the outcome of emergency colectomy of the left colon demonstrated excellent oncologic results compared to that of the elective group. However, emergency operation carries some degree of higher complication rate that need to be taken into account. Best results will be achieved by tailoring each patient’s status with the utilization of the best operation and operative team experience.
Enhancing Multisensory Experiences Through Temperature-Controlled Wind Effects
Authors: Saleme Estevao Bissoli , Silveira Aleph Campos da , Covaci Alexandra , Rodrigues Eduardo , Santos Celso Alberto Saibel , Ghinea Gheorghita
Published: February 2023

In this paper, we introduce Twirl, a haptic system that allows the creation and delivery of hot and cold airflow synchronised with audiovisual content. Twirl combines vaporization of cooled water by Peltier elements for cold wind and hair dryers for warm wind steered by wind fans. To assess our system, we conducted several studies. First, we analyzed the time our devices take to deliver these effects considering different starting temperatures in the environment. Then, we annotated three videos with hot wind, cold wind, and both effects respectively to observe the feasibility of having those effects integrated with audiovisual content. Next, we assessed the temperature variation of the devices as a function of distance. Finally, we distributed questionnaires such as Virtual Reality Hardware Acceptance Model and Lombard's Temple Presence Inventory questionnaires to assess different user experience facets and attitudes towards the proposed device. Preliminary results highlighted positive user attitudes and experiences towards Twirl.
Downregulated DUXAP8 lncRNA impedes trophoblast cell proliferation and migration by epigenetically upregulating TFPI2 expression
Authors: Tang Xiaotong , Cao Yueying , Wu Dan , Xu Yetao , Sun Lizhou
Published: February 2023

Backgorund
Preeclampsia (PE), a pregnancy complication characterized by new-onset hypertension and proteinuria during the second trimester, is the leading cause of neonatal and maternal morbidity and mortality. In the etiology of PE, failure of uterine spiral artery remodeling may be related to functioning abnormally of trophoblast cells, leading to the occurrence and progression of PE. Recently, long noncoding RNAs (lncRNAs) have been reported to play critical roles in PE nowadays. This study aimed to investigate the expression and functions of the TFPI2 pathway-related lncRNA DUXAP8.
Methods
DUXAP8 expression in the placenta from pregnancies was examined using qPCR. Then, the in vitro functions of DUXAP8 were investigated through MTT, EdU, colony, transwell, and flow cytometry experiments. The downstream gene expression profiles were assessed using RNA transcriptome sequencing analysis and verified using qPCR and western blot. Furthermore, Immunoprecipitation (RIP), chromatin immunoprecipitation (CHIP) and fluorescence in situ hybridization (FISH) were used to detect the interaction between lncDUXAP8/EZH2/TFPI2.
Results
The expression of lncRNA DUXAP8 in placenta of patients with eclampsia was significantly decreased. After knockout of DUXAP8, the proliferation and migration of trophoblasts were significantly decreased, and the percentage of apoptosis was increased. Flow cytometry showed that low expression of DUXAP8 increased the accumulation of cells in G2/M phase, while overexpression of DUXAP8 had the opposite effect. We also proved that DUXAP8 epigenetically inhibited TFPI2 expression by recruiting EZH2 and mediating H3K27me3 modification.
Conclusion
Together, these resulting data clarify that aberrant expression of DUXAP8 is involved in the potential PE development and progress. Unraveling the role of DUXAP8 will provide novel insights into the pathogenesis of PE.
Differential responsesof pulmonary vascular cells from PAH patients and controls to TNFα and the effect of the BET inhibitor JQ1
Authors: Mumby S , Perros F , Grynblat J , Manaud G , Papi A , Casolari P , caramori G , Humbert M , Wort S J , Adcock I M
Published: February 2023

Background
Pulmonary arterial hypertension (PAH) encompasses a group of diseases characterized by raised pulmonary vascular resistance, resulting from vascular remodelling and inflammation. Bromodomain and extra-terminal (BET) proteins are required for the expression of a subset of NF-κB-induced inflammatory genes which can be inhibited by the BET mimic JQ1+. We hypothesised that JQ1 + would supress TNFα-driven inflammatory responses in human pulmonary vascular cells from PAH patients.
Methods
Immunohistochemical staining of human peripheral lung tissue (N = 14 PAH and N = 12 non-PAH) was performed for the BET proteins BRD2 and 4. Human pulmonary microvascular endothelial cells (HPMEC) and pulmonary artery smooth muscle cells (HPASMC) from PAH patients (N = 4) and non-PAH controls (N = 4) were stimulated with TNFα in presence or absence of JQ1 + or its inactive isomer JQ1-. IL-6 and − 8 mRNA was measured by RT-qPCR and protein levels by ELISA. Chromatin immunoprecipitation analysis was performed using EZ-ChIP™ and NF-κB p65 activation determined using a TransAm kit. MTT assay was used to measure cell viability.
Results
Nuclear staining of BRD2 and BRD4 was significantly (p < 0.0001) increased in the lung vascular endothelial and smooth muscle cells from PAH patients compared to controls with normal lung function. TNFα-driven IL-6 release from both HPMECs and HPASMCs was greater in PAH cells than control cells. Levels of CXCL8/IL-8 protein release was higher in control HPASMCs than in PAH cells with similar release observed in HPMECs. TNFα-induced recruitment of activated NF-κB p65 to the IL-6 and CXCL8/IL-8 promoters were similar in both cell types and between subject groups. JQ1 + suppressed TNFα-induced IL-6 and CXCL8/IL-8 release and mRNA expression to a comparable extent in control and PAH HPMECs and HPASMCs. JQ1 had a greater efficacy on IL-6 release in HPMEC and on CXCL8/IL-8 release in HPASMC.
Conclusion
BET inhibition decreases TNFα driven inflammation in primary pulmonary vascular cells. JQ1 anti-inflammatory actions suggests distinct cell-specific regulatory control of these genes. BET proteins could be a target for future therapies for PAH.
Agreement of wall shear stress distribution between two core laboratories using three-dimensional quantitative coronary angiography
Authors: Kageyama Shigetaka , Tufaro Vincenzo , Torii Ryo , Karamasis Grigoris , Rakhit Roby , Poon Eric , Aben Jean-Paul , Baumbach Andreas , Serruys Patrick , Onuma Yoshinobu , Bourantas Christos
Published: February 2023

Purpose: Wall shear stress (WSS) estimated in models reconstructed from intravascular imaging and 3-dimensional-quantitative coronary angiography (3D-QCA) data provides important prognostic information and enables identification of high-risk lesions. However, these analyses are time-consuming and require expertise, limiting WSS adoption in clinical practice. Recently, a novel software has been developed for real-time computation of time-averaged WSS (TAWSS) and multidirectional WSS distribution. This study aims to examine its inter-corelab reproducibility.
Methods: Sixty lesions (20 coronary bifurcations) with a borderline negative fractional flow reserve were processed using the CAAS Workstation WSS prototype to estimate WSS and multi-directional WSS values. Analysis was performed by two corelabs and their estimations for the WSS in 3mm segments across each reconstructed vessel were extracted and compared.
Results: In total 700 segments (256 located in bifurcated vessels) were included in the analysis. A high intra-class correlation was noted for all the 3D-QCA and TAWSS metrics between the estimations of the two corelabs irrespective of the presence (range: 0.90-0.92) or absence (range: 0.89-0.90) of a coronary bifurcation, while the ICC was good-moderate for the multidirectional WSS (range: 0.72-0.86). Lesion level analysis demonstrated a high agreement of the two corelabls for detecting lesions exposed to an unfavourable haemodynamic environment (WSS >8.24Pa, κ=0.77) that had a high-risk morphology (area stenosis >61.3%, κ=0.71) and were prone to progress and cause events.
Conclusion: The CAAS Workstation WSS enables reproducible 3D-QCA reconstruction and computation of WSS metrics. Further research is needed to explore its value in detecting high-risk lesions.
Cross-sectional evaluation of outcome comparison methodology in dermatologic clinical trials and a simulation-based discussion of why outcome comparison technique matters
Authors: Hopkins Zachary H. , Swink J. Michael , Kaprive Jessica Forbes , Carlisle Ryan , Olayinka Jadesola , Moreno Christopher , Frost Zachary , Secrest Aaron M.
Published: February 2023

Clinical trial outcome comparison methodology can affect trial efficiency and interpretation. Our goal was to describe current trends in clinical trial outcome comparison methods among high-impact dermatology trials and perform simulations comparing direct comparison (DC), change-score based (CS), and baseline-adjusted analyses (BAA) to demonstrate the more subtle differences in these methods. We performed a cross-sectional examination of top-cited dermatology clinical trials over five years. Trials were retrieved from journal websites and extracted from PubMed. All clinical trials published in The Journal of the American Academy of Dermatology (JAAD), JAMA Dermatology, Journal of Investigative Dermatology (JID), The British Journal of Dermatology (BJD), and The Journal of the European Academy of Dermatology and Venereology (JEADV) from 2015–2019. Clinical trial analysis type including DC, CS, BAA, percent change from baseline (PoB), and responder analysis (RA). We evaluated the proportion of trials reporting each endpoint were reported and simulations assessing impact of analysis type on outcomes. Among 252 eligible trials, outcome comparison techniques included DC (75/252), CS (40/252), PoB (36/252), RA (98/252), and BAA (3/252). Among trials using CS, PoB, or RA, 25/174 adjusted for baseline score. No trials discussed relationship between baseline and final values; 85/252 selected patients based on baseline score; 8/85 gathered a post-randomization baseline score; 20/85 used a pre-randomization run-in period. Simulations demonstrated that BAA maximized trial efficiency for continuous outcomes. CS, PoB, and RA were common; however, when trials have continuous or ordinal outcomes, BAA is most efficient. PoB and RA are particularly inefficient. RA can promote misleading inference. Use of BAA optimizes inference, trial efficiency, and resource utilization.
On a Possible Mechanism for the Start or Resumption of Activity of Radio Galaxies in Clusters of Galaxies
Authors: Andreasyan Ruben , Abrahamyan Hayk , Paronyan Gurgen , Mikayelyan Gor , Mickaelian Areg
Published: February 2023

We study the close proximity of the well-known and well-studied 3C31 class FRI radio galaxy in order to reveal the influence of the environment on an extragalactic radio source. It was shown that about 110 million years ago the galaxies NGC 380 and NGC 386 were located near the galaxy NGC 383 (the parent galaxy of 3C31). On the other hand, the modeling of the spectral characteristics of the radio emission of the central part of the radio galaxy 3C31 gives an estimate of the age of the central jet of about 100 million years. Therefore, it can be assumed that one of the possible reasons for the appearance or resumption of the radioactivity of the galaxy NGC 383 may be a triple close passage of galaxies.
Environmental impact of sabotage of the Nord Stream pipelines
Authors: Sanderson Hans , Czub Michał , Koschinski Sven , Tougaard Jakob , Sveegaard Signe , Jakacki Jaromir , Fauser Patrik , Frey Torsten , Bełdowski Jacek , Beck Aaron , Przyborska Anna , Szturomski Bogdan , Kiciński Radosław
Published: February 2023

Armed conflicts have, in addition to severe impacts on human lives and infrastructure, also impacts on the environment, which needs to be assessed and documented. On September the 26th 2022, unknown perpetrators deliberately ruptured the two gas pipelines Nord Stream 1 and 2 with four coordinated explosions near a major chemical munition dump site near the Danish island of Bornholm in the Baltic Sea. While the massive release of natural gas into atmosphere raised serious concerns for climate, this paper assesses the overlooked direct impact of this sabotage on marine ecosystem. Seals and porpoises within a radius of four km would be at high risk of being killed by the shockwave, while temporary impact on hearing would be expected up to 50 km away. As the Baltic Proper population of harbour porpoises (Phocoena phocoena) is critically endangered, the loss or serious injury of even a single individual is considered a significant impact on the population. The rupture resulted in the resuspension of 250.000 metric tons of heavily contaminated sediment from deep-sea sedimentary basin for over a week, resulting in unacceptable risks towards fish and other biota in 11 km3 water for more than a month.
Quantum anisotropic antiferromagnetic Heisenberg model for description of magnetic properties at low temperatures from KTb(WO4)2
Authors: Freitas A. S. , Silva C. A. , cd L. S. Silva
Published: February 2023

Low dimensional magnetic systems have attracted the attention of several researchers in recentdecades, mainly because from exotic magnetic properties and the superconductivity that, in someof these systems, occur as result from characteristics of such materials. One of these materialsis KTb(WO4)2, generally considered a prototype from 2D Ising model, but which presents somepeculiarities on the magnetization diagram at low temperatures, especially the non-linear dependenceof magnetization with the applied magnetic field, behavior that cannot be described via puretwo-dimensional Ising model. The system presents structural and metamagnetic phase transition atlow temperatures, and we believe that such behavior may be related quantum effects and despitepresenting high anisotropy, this material it would not be a perfect prototype of the Ising model intwo dimensions. In this work, we present a proposal for using the anisotropic quantum Heisenbergmodel for describing the magnetic properties of the KTb(WO4)2 quasi-doublet with the objective,mainly, to describe non-linear properties at low temperatures. To achieve our goal, we simulatedthe magnetic properties of the material considering several anisotropy values via Quantum MonteCarlo (QMC) and compared the results with experimental data available already published. Tocomparison, we obtained diagrams of magnetization versus field and susceptibility dependence oftemperature (low temperature regime). Our results show excellent agreement with the experimentaldata, especially at low temperatures and for intermediate values from magnetic anisotropy.
ExomiRHub: a comprehensive database platform to integrate and analyze human extracellular miRNA transcriptome for discovering non-invasive biomarkers
Authors: Liu Yang , Min Zhuochao , Mo Jing , Ju Zhen , Chen Jianliang , Li Hanguang , Liang Weiling , Chan Godfrey Chi-Fung , Wei Yanjie , Zhang Wenliang
Published: February 2023

Background
Although studies reported that extracellular miRNAs have significant functions in regulating the development of human diseases, our understanding of their role in human diseases remains to be further addressed. Many extracellular miRNA expression data were deposited in public resources, which are heterogeneous and difficult to investigate due to the data generated from different high throughput platforms. To use these invaluable data for accelerating the discovery of non-invasive miRNA biomarkers, a comprehensive and user-friendly database platform is essential, especially for bench researchers who lack bioinformatics skills.
Methods
We integrated, standardized, and annotated human extracellular miRNA expression data and cancer-related miRNA transcriptome data from NCBI GEO and The Cancer Genome Atlas (TCGA), respectively. Moreover, we developed the ExomiRHub database platform that designed with comprehensive online analysis functions and tools to analyze these data or User's own data. These analysis functions and tools were designed to enable users to select samples, define groups and parameters for their own analysis.
Results
ExomiRHub includes 191 human extracellular miRNA expression datasets associated with 112 disease phenotypes, 62 treatments, and 24 genotypes, including 29,198 samples and 23 sample types. ExomiRHub further includes 16,012 miRNA transcriptome data of 156 cancer sub-types to enhance the usability of it in cancer research. To accelerate the identification of non-invasive miRNA biomarkers, ExomiRHub provides 25 online analytical and visualization functions to individually analyze these data. Moreover, ExomiRHub provides Web Service to enable users in conducting the analyses on their uploaded data. Furthermore, ExomiRHub provides four additional tools to evaluate the functions and targets of miRNAs and their variations. Finally, we used ExomiRHub and discovered non-invasive miRNA biomarkers associated with angiogenesis-related pathways for monitoring glioma progression.
Conclusion
The comprehensive data and functions of ExomiRHub can greatly accelerate the discovery of non-invasive miRNA biomarkers. It is freely accessible at the websites of http://hpcc.siat.ac.cn/exomirhub/ & http://www.biomedical-web.com/exomirhub/.
Evaluation of the Potential of Trade Gains for Nigeria in the African Continental Free Trade Agreement (AfCFTA)
Authors: Jato Terungwa Paul Joseph , Nwankwo Nneka , Awuzie Esther Ijeoma
Published: February 2023

Challenged by slow growth and development, there has been increased need and search for avenues that will bring accelerated development to the African continent. Such attempts include the African Continental Free Trade Agreement (AfCFTA) entered into by some African countries including Nigeria. The AfCFTA promises benefits for reginal development through individual benefits to member countries from trade. The study, thus, evaluated Nigeria’s potential of trade gains from the AfCFTA. The gravity model of trade was applied to analyze data about the variable obtained for Nigeria and some African states. The major findings of the study show that, the volume of Nigeria’s GPD, the distance between Nigeria and the trading partners, the Nigeria’s population, the per capital income in the region, the degree of trade openness, and sharing a colonial link with a country are capable of increasing trade flows to Nigeria, thus increasing her chances of gaining from the AfCFTA. Other variables like, the GDP of the trading partners, their population, and being a member of AfCFTA have the potential of lowing trade flow to Nigeria, all things being equal. It was concluded that Nigeria stands to benefit from her trade with these countries in the African continental free trade arena, all things being equal. Foreign trade policy actions should therefore be geared toward increased trade between these member states.
JEL Classification Code: C51, F17, F43, F53
Ukrainian Reality Shows as a Tool of Discrimination (on the Example of the Program «Supermama»)
Authors: Zinenko Oleksandra
Published: February 2023

Introduction. Children’s rights need special attention, as they cannot make their own decisions and need the protection and care of their parents. At the same time, parents can take advantage of their children. This also applies to the participation of children in reality shows. It is the responsibility of both parents and the film crew to comply with the legal framework of Ukraine regarding children’s participation in media projects, providing comfortable physical and psychological conditions for filming, caring for the child’s psychological state during filming and after the show.
Purpose and relevance. The reality show «Supermama» which involves not only adult protagonists but also their children is selected for analysis. The participation of minors
in the program can lead to violations of their rights and discrimination, as well as the establishment of stereotypes in society about the treatment of children. Currently, research on discrimination against children in the media is just beginning in Ukraine, and research on discrimination in reality shows has not yet been conducted. Based on the analysis of 4 seasons of reality shows, the article provides recommendations for TV companies to work with children in the process of creating a reality show.
The research methodology. The research used methods of analysis and synthesis of empirical data, content analysis, abstraction to identify discriminatory practices in the plots of the program, deductive method for summarizing.
Results. The study analysed the discriminatory practices of the «Supermama» program for participating children and the impact on child viewers. It has been established that
program producers and main participants repeatedly violate the rights of minors (negative coverage of their lives, negative comments on children and the upbringing process in general in the program, misogyny, violations of the law on media work with children, etc.) and inflict destructive influence on child viewers. transmitting and perpetuating stereotypes and regulating discrimination on various grounds.
Conclusions. Recommendations for working with children in the filming process and the post-production phase were made. The article can be a basis for researching discriminatory practices against children in reality shows and the media in general. The findings can also be used to establish the dynamics of overcoming discrimination against children in the Ukrainian media.
Convergence as an aspect of the work of affiliates of the public broadcaster in the wartime period
Authors: Mostipan Tetiana
Published: February 2023

Introduction. Ukrainian society needs operational and verified news, especially in the conditions of war. Mass media should respond to such requests from the audience.
Relevance of the study. The number of subscribers and pages of affiliates of the public broadcaster in the regions is constantly growing. Therefore, the study of the broadcaster's work on social networks is relevant.
Methodology. The main method was content analysis. By the method of comparison, the common and distinctive features of the work of convergent editorial offices have been established. The method of systematization made it possible to determine the peculiarities of the work of mass media on individual sites. The method of generalization made it possible to record the identified trends.
Results. The work of regional affiliates to fill information platforms with content has common and distinctive features. Up to 15 messages were published daily on the broadcaster's websites in Transcarpathia, Rivne, and Sumy regions in May. The Telegram page was used by all three affiliates to notify about alarms and inform about news of local and all-Ukrainian importance. The Facebook pages of the branches of the public broadcaster in Transcarpathia, Rivne and Sumy regions worked according to a similar scheme: they published regional and all-Ukrainian news. Alarm notifications on this site were distributed only in Transcarpathia. Youtube video hosting was used by all three branches with varying intensity.
Conclusions. The most popular among content consumers are Facebook pages, the total number of followers of the three branches is 158,000. Instagram pages and Viber channels have the fewest followers, 57,500 and 57,000 followers, respectively. The number of followers on media pages in social networks indicates the relevance of the work convergent editions and the need for further improvement of the concepts of information filling of patforms.
Evaluation of three viral concentration methods for detection and quantification of SARS-CoV-2 in wastewater
Authors: Othman Ines , Helmi Amna , Slama Ichrak , Hamdi Rawand , Mastouri Maha , Aouni Mahjoub
Published: February 2023

Wastewater-based epidemiology (WBE) could be useful as an early warning system for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic spread. Viruses are highly diluted in wastewater. Therefore, a virus concentration step is needed for SARS-CoV-2 wastewater detection. We tested the efficiency of three wastewater viral concentration methods: ultrafiltration (UF), electronegative membrane filtration and aluminum hydroxide adsorption–elution. We spiked wastewater with inactivated SARS-CoV-2 and we collected 20 other wastewater samples from five sites in Tunisia. Samples were concentrated by the three methods and SARS-CoV-2 was quantified by reverse transcription digital PCR (RT-dPCR). The most efficient method was UF with a mean SARS-CoV-2 recovery of 54.03 ± 8.25. Moreover, this method provided significantly greater mean concentration and virus detection ability (95%) than the two other methods. The second-most efficient method used electronegative membrane filtration with a mean SARS-CoV-2 recovery of 25.59 ± 5.04% and the least efficient method was aluminum hydroxide adsorption–elution. This study suggests that the UF method provides rapid and straightforward recovery of SARS-CoV-2 in wastewater.
Evaluation of aquatic phytoremediation technologies in urban black–odorous water remediation technology using a multi-level fuzzy analysis method
Authors: Zhang Yue , Huang Peng , Fan Bo , Zhao Qing , Tian Tengfei , Zhang Weijia
Published: February 2023

The comprehensive analysis and research on the selection and evaluation of technology for urban black and odorous water remediation have not yet formed a complete system, and the technical analysis and comparison of the remediation technology are not combined with the characteristics of the river and the pollution status, which often could not achieve the expected effect. Combining the multi-level index division and fuzzy weight matrix calculation method, this paper establishes a comprehensive evaluation method for urban black–odorous water treatment technology based on multi-level fuzzy analysis. The proposed method was applied to assess four kinds of in situ purification-aquatic plant remediation technologies. The results showed that the pollutants removal efficiency of a submerged plant was much higher than that of an emergent aquatic plant, floating-leaved water plant and floating plant. Meanwhile, according to the evaluation model, the comprehensive grading order of in situ purification-aquatic plants was as follows: emergent aquatic plant (84.2044) > submerged plant (78.838) > floating-leaved water plant (72.7596) > floating plant (66.4312). The calculations indicated that the ecological restoration project of black and odorous water should build an ecological restoration technology system based on in situ purification-submerged plant remediation technology, supplemented by other three types of aquatic phytoremediation technologies.
Activated carbon production from plum pit shells for oily wastewater treatment
Authors: Yessenbek Assylbek , Satayev Marat , Azimov Abdugani
Published: February 2023

The aim of the research is the production of activated carbon from the plum pit shells in a drum-type steam-gas furnace. To study the production of activated carbon, methods were used based on the study of individual patterns, analysis of the specific surface, determination of the porous structure, analysis of the structural-sorption and physicochemical characteristics of the pit shell. The novelty is research on determining the characteristics of activated carbon and the effect of thermal activation temperature in a flow of CO2 and H2O in a mass ratio of 20:80 on the pore volume. During activation at a process temperature of 780 °C, the surface was destroyed by powerful thermal activation, and as a result, micropores of 8–10 μm formed and a cell configuration arose. The adsorption kinetics showed that the maximum efficiency is achieved at a duration of 0.5 h for chloroform-extracted and 2 h for hexane-extracted oil products, as well as an adsorbent dose of 4 kg/m3. The results obtained in the research of the process of oily wastewater treatment showed that the effect of treatment with the activated plum pit shells (95.5%) is greater than the effect of treatment with coagulants and clays (88.5–71)%.
Multiobjective design of water distribution networks using modified NSGA-II algorithm
Authors: Naidu M. Naveen , Vasan A. , Varma Murari R. R. , Patil Mahesh B.
Published: February 2023

Optimally designed water distribution networks (WDNs) make engineers’ tasks difficult due to various challenges like non-linearity between head-loss and flow, commercially available distinct diameters, combinatorial, nondeterministic polynomial-time hard problems and a large number of decision variables. This paper develops a new hybrid NSGA-II algorithm augmented with a random multi-point crossover operator and a local search denoted by RLNSGA-II to design the multiobjective WDN. The efficiency of the proposed algorithm (RLNSGA-II) is tested on three benchmark problems, namely New York, Hanoi and Balerma networks. The results obtained are compared with the best-known algorithms available in the literature. The results have shown that the proposed algorithm RLNSGA-II has found better converged and distributed solutions for all three representative benchmark problems considered in the literature consistently and evidently when compared with the best-known approximation of solutions published. Furthermore, as the complexity of the WDN increases, its advantages over other algorithms become more significant.
natureza reticulada das cidades e do urbano
Authors: Furini Luciano Antonio
Published: February 2023

A urbanização é um fenômeno mundial que se constitui a partir de inúmeros vetores em que as cidades são os principais nós das redes interurbanas, mas que guardam inúmeras redes intraurbanas. É no contexto de uma crescente complexidade tecnológica que tais vetores diferenciam o território e produzem cidades com papéis diferenciados, gerando padrões bastante diversos de redes urbanas, mas que guardam a potencialidade de redefinição espacial segundo as tendências contidas na lógica do mercado e nos diferentes formatos de atuação dos governos e instituições. A remodelação dos territórios é acionada a partir de diferentes escalas geográficas em que as escalas de comando e de impacto polarizam os fluxos das redes em ritmos ditados de acordo com os setores que desencadeiam a estruturação e as práticas espaciais. Neste texto, será apresentado o caráter reticulado da cidade e do urbano e seus desdobramentos no processo de fragmentação socioespacial urbana. Os resultados são oriundos das pesquisas sobre redes socioespaciais em cidades brasileiras e mostram que na análise espaço-temporal da cidade e do urbano as redes constituem um elemento central e seu estudo permite compreender tendências centrais de temas tão caros ao conhecimento geográfico.
CULTURA E HISTÓRIA DA POPULAÇÃO AFRO-BRASILEIRA E AFRICANA NO CURRÍCULO ESCOLAR: O NEGRO E SUA SOCIABILIDADE.
Authors: De Oliveira Gerson Alves
Published: February 2023

A inserção da cultura e historia da população afro-brasileira e africana no currículo escolar, gerou a necessidade de uma releitura acerca do lugar que as tradições de ancestralidade africanas ocupam na ordem social dominante no Brasil, bem como significou uma ruptura no plano teórico com as abordagens que se caracterizavam com a desumanização da população negra em nosso país. Neste sentido, a proposta deste texto é pensar de que modo podemos identificar costumes, hábitos e valores, definidores de um sentimento étnico no que tange a população afro-brasileira e africana, além de tentar elaborar um caminho que aponte para uma prática escolar capaz de ir além da lei em si. Isto é, pensar a relação entre teoria e prática na escola como algo interconectado, capaz de revelar mais que meros indivíduos herdeiros de uma herança cultural e, sim, observar o “espaço negro proibido”, lugar onde uma identidade se reforça e se reconstrói por meio de uma sociabilidade que aparece nas práticas sociais de uma população, cujas experiências e vivências revelam uma ancestralidade africana.
JEAN-JACQUES ROUSSEAU: UMA SISTEMATIZAÇÃO DOS ARTIGOS SOBRE SUA TEORIA
Authors: Kieckhoefel Thaís , Ersching Clevia Bittencurt , Henning Elisa , Pereira Kariston , Sell Fabíola Sucupira Ferreira
Published: February 2023

Jean-Jacques Rousseau viveu no conhecido “século das luzes” ou iluminismo, possuía ideias que influenciaram vários intelectuais assim como a Revolução Francesa. Desde essa época suas ideias causavam controvérsias. Com o intuito de verificar em quais áreas do conhecimento a teoria de Rousseau influencia a atualidade, realizou-se um mapeamento sistemático dos artigos escritos nos últimos sete anos. Dos artigos encontrados pode-se evidenciar as área de concentração: Educação, Formação Humana/ Natureza, Infância, Desigualdade de Gênero. Percebe-se que a teoria de Rousseau ainda é muito discutida e polemizada, pois este trazia uma ideia de educação natural ao mesmo tempo em que colocava a mulher como submissa ao homem.
Artigo VI “Se o conhecimento intelectual é adquirido a partir das coisas sensíveis?”
Authors: Brzozowski Sonia
Published: February 2023

ResumoNa História da Ciência estudamos as diferentes formas de elaboração, transformação e a transmissão do conhecimento sobre a natureza nas diferentes épocas e culturas. Neste estudo pretendemos analisar o desenvolvimento do processo de produção de conhecimento no século XIII a partir das considerações feitas por Tomas de Aquino no seu artigo VI - “Se o conhecimento intelectual é adquirido a partir das coisas sensíveis ?” que consta na Questão 84 da 1ª Parte da obra Suma de Teologia.Palavras-chaves: História da Ciência; Conhecimento;Tomás de Aquino.
O Estado contra a educação
Authors: Silva Victor Leandro , Lopes Matheus Cascaes
Published: February 2023

Desde a República platônica até a constituição dos Estados modernos, a educação sempre foi pensada como uma forma de controle social sobre os indivíduos. Desse modo, ela viria a ser constituída como um dos mais fortes transmissores dos princípios que norteiam a ideologia dominante. O presente texto procura analisar de que maneira, a partir das análises das obras de Platão e Louis Althusser, o estatuto ideológico hegemônico se torna presente nos processos educativos, bem como discutir, por meio da relação entre escola e trabalho, as propostas de ruptura frente a essa condição.
Alguns aspectos das noções de governamentalidade e governabilidade como processo de constituição de si na educação
Authors: Araújo Alencar Bruno , Mota Fernanda
Published: February 2023

O artigo tem como objetivo de discutir a partir da perspectiva de Michel Foucault os dispositivos de coerção do sujeito na educação através dos conceitos de governamentalidade e governabilidade como processo de constituição de si. Para tanto faremos uma breve contextualização histórica acerca da constituição dos processos de dominação dos sujeitos dos primórdios até a contemporaneidade. Em seguida, faremos algumas breves discussões acerca dos conceitos foucaultianos de governamentalidade, governabilidade e constituição de si. Posteriormente, evidenciaremos a articulação dos referidos conceitos no campo educacional. Nosso aporte teórico está fundamentado em autores como: Foucault (2017), Mota (2017), Pagni (2017), e Silva (2010), além de outros. Nosso estudo indica que o sujeito ao longo desse processo de constituição é dominado por um conjunto de normas que o definem como ser pronto e acabado para uma finalidade específica no seu campo social, mas que a partir da constituição de si é capaz de agregar conhecimentos filosóficos que o libertam de modos de agir e de pensar predefinidos.
Convite à autonomia da razão: considerações sobre a identidade docente do professor de filosofia
Authors: Da Cunha Jr. Williams Nunes
Published: February 2023

A recolocação do ensino de filosofia nas escolas públicas de ensino médio nos leva a questionar sobre a identidade do professor de filosofia desta etapa especifica. Quase dez anos depois da lei 11.684/2008, perguntamo-nos quem é o docente de filosofia, o que ele deve ter/fazer, qual sua especificidade enquanto tal. O presente artigo, objetiva discutir como deve proceder e quais características não deve faltar aquele que abraça a tarefa de ensinar Filosofia. Por meio de uma revisão de literatura já existente sobre o ensino de Filosofia, através da leitura bibliográfica de GALLO e ASPIS (2009), GHEDIN (2009), KOHAN (2008), dentre outros, percebemos que um dos elementos dessa identidade se dá na concepção do professor de filosofia como um filósofo. Sendo assim, urge-nos superar esta dicotomia que parece separar o filosofar do ensino de filosofia, como se o professor fosse um mero reprodutor de conhecimentos filosóficos, posição esta contestada pelos autores que aqui abordamos. O docente de filosofia é aquele que convida ao pensamento crítico e autônomo, rejeitando, portanto, essa reprodução de teorias filosóficas. Ademais, cabe salientar que refletir sobre este ensino é um problema filosófico, o que o torna uma tarefa primordial do professor de filosofia/filósofo. Há muitas lacunas ainda que precisam ser sanadas e é refletindo constantemente sobre essa prática que podemos descortinar novos horizontes para um autêntico ensino de Filosofia.
A reforma do ensino médio brasileiro e o lugar da filosofia na Lei 13.415/17
Authors: Novaes T. de Menezes Antonio Basilio , Silva Roberto Ribeiro
Published: February 2023

O presente estudo elaborado é baseado em um levantamento e revisão bibliográfica. Tem o intuito de entender em que medida a não obrigatoriedade da disciplina de Filosofia dentro das políticas de Estado, pode representar a negação de conteúdos de profunda relevância a formação para a cidadania e consequentemente emancipação de jovens e crianças escolarizados. Neste sentido, relacionou os conceitos da reflexão política de alguns pensadores em vista de fornecer elementos e categorias de análises aos pesquisadores no campo educacional, mais especificamente, ligados à Filosofia na escola e sua “importância” na atual política de Estado. A partir das análises, nossos resultados nos mostram que tal reforma, tem se mostrado como política ideológica intencionada de uma classe ao controle social em detrimento a outra.
A ASCENSÃO DA MÁQUINA POLÍTICA MODERNA: HOBBES, LOCKE E MONTESQUIEU
Authors: Mariano Pires Felipe Augusto
Published: February 2023

Este trabalho analisou as funções atribuídas à vontade e à virtude na história da teoria das formas de governo em relação com a possibilidade de participação do povo no poder. A análise partiu de quatro pilares, a teoria das formas de governo, a ideia do bem comum, a ideia de tirania do povo e o que foi chamado de núcleo argumentativo da filosofia política. Através da comparação dos autores selecionados, chegamos aos núcleos argumentativos desta época. O núcleo moderno começa a se formar através da ideia de um mecanismo capaz de permitir que a vontade governe em direção ao bem comum, terminando por formar um mecanismo composto por três poderes, sistema de freio do poder, estado de legalidade, direitos naturais e vontade na centralidade do núcleo.
REVISÃO SOBRE AS ATIVIDADES LÚDICAS NO ENSINO DE QUÍMICA
Authors: Dias de Souza Bruno , Fonseca Jardim Vianna Carlos Alberto
Published: February 2023

As atividades lúdicas são uma importante estratégia metodológica para incentivar o processo de ensino-aprendizagem em Química. Um mapeamento organizado dessas pesquisas, que facilite a compreensão das suas características, benefícios e aplicações, pode ser útil ao professor que deseja conhecer e utilizar as atividades lúdicas no ensino de Química. O presente artigo tem como objetivo mapear e revisar pesquisas que envolveram as atividades lúdicas no ensino de Química. Para tanto, foram identificados e mapeados, via pesquisa de caráter exploratório, os artigos sobre atividades lúdicas no ensino de Química, publicados nos periódicos Química Nova, Química Nova na Escola e no Encontro Nacional de Pesquisa em Educação em Ciências (ENPEC), entre janeiro de 2016 e maio de 2021. Os artigos utilizados nesta pesquisa foram acessados eletrônica e digitalmente, pela internet, usando palavras-chave previamente selecionadas, tais como: lúdico, ludicidade, brincadeira, jogo. Dentre os resultados, observou-se que o uso de jogos de tabuleiro na sala de aula teve maior incidência e que a utilização das tecnologias digitais de informação e comunicação (TDIC’s) apresentaram tendência de crescimento em relação aos anos anteriores no período demarcado na nossa análise. Verificou-se que o uso do lúdico pelo professor pode ser uma ferramenta útil para o ensino de conceitos da disciplina de Química, na promoção do interesse, da participação e do aprofundamento dos temas a serem ensinados em sala de aula.
ESTUDANTES COM DEFICIÊNCIA NO ENSINO REMOTO
Authors: Couto Pimentel Susana , Guimarães Miranda Theresinha
Published: February 2023

O ensino remoto emergencial foi uma alternativa educacional encontrada para minimizar os efeitos das medidas de distanciamento social, durante a crise sanitária decorrente da pandemia da Covid 19, em virtude dos riscos de contágio pelo coronavírus SARS-COV-2. Essa mudança abrupta no meio de realização do ensino, do presencial para o remoto, gerou a necessidade de readequação das instituições com vistas a minimizar danos pedagógicos e garantir qualidade nos processos de ensino e aprendizagem. As readequações abrangeram aspectos diversos, dentre os quais: disponibilização de ferramentas digitais; ampliação das redes de dados; formação de professores; condições de acessibilidade etc. Nesse sentido, esta investigação teve como objetivo analisar produções divulgadas em periódicos do Brasil, no último biênio, sobre como os estudantes com deficiência foram incluídos no ensino remoto em cursos de graduação. Como metodologia foi utilizada a revisão de literatura, a partir de publicações divulgadas no Portal de Periódicos da CAPES. Os resultados indicam, por um lado, um silenciamento acadêmico sobre a inclusão de estudantes com deficiência no ensino remoto emergencial, sendo encontrados apenas três artigos e, por outro lado, revela uma tendência de investimentos institucionais em recursos digitais acessíveis e pouca ênfase em acessibilidade metodológica no ensino mediado por tecnologias. Ademais, as produções analisadas abordam, majoritariamente, as condições de acessibilidade relativas à deficiência visual e auditiva. O silenciamento sobre essa temática ratifica a invisibilidade vivenciada por esse segmento da população na educação superior, sendo necessário reafirmar o direito de aprender por todos os estudantes e a criação de condições para esse fim.
ALTAS HABILIDADES OU SUPERDOTAÇÃO DO TIPO CRIATIVA
Authors: Nakano Tatiana , Reis Negreiros Júlia , Wonsik Cano Isabella , Fusaro Giovanna Julia , Rovina Batagin Lais
Published: February 2023

o presente estudo visou realizar uma triagem visando identificar, dentre universitários de um curso de Psicologia, aqueles que apresentavam sinais indicadores de altas habilidades ou superdotação do tipo criativa. Alunos que cursavam o 5º semestre de uma instituição privada, em um total de 124 estudantes, com idades entre 19 e 39 anos (M=21,1 anos; DP=2,61), sendo 101 do sexo feminino (81,5%) participaram da pesquisa. A amostra respondeu a um teste de criatividade figural, composto por duas atividades, nas quais são fornecidos estímulos incompletos, os quais devem ser respondidos sob a forma de desenhos. A pontuação total de cada estudante foi calculada, bem como a média e desvio padrão da amostra. A fim de identificar os estudantes que apresentavam sinais indicadores de AH/SD criativa, adotou-se o critério estabelecido na literatura, ou seja, pontuação correspondente a dois desvios padrão acima da média, de modo a caracterizar a superdotação. Cinco estudantes preencheram esse critério, cerca de 4% da amostra total. Um segundo critério, desempenho de um desvio padrão acima da média, também foi aplicado, de modo que mais 16 estudantes foram identificados com altas habilidades, além dos cinco já selecionados pelo critério anterior. Os resultados indicaram a presença de estudantes com sinais indicadores de altas habilidades/superdotação na área criativa e que, até o presente momento, não haviam sido identificados ao longo de sua trajetória escolar. A indicação de avaliação mais aprofundada será encaminhada aos estudantes com indicadores, recomendando-se que pesquisas voltadas à identificação de outros tipos de superdotação possam ser conduzidas na instituição.