bluuebunny/crossref_metadata_2025 huggingface dataset:
OMI/NOMI: Time for a New Classification of Acute Myocardial Infarction
Authors: Kola Martiola , Shuka Naltin , Meyers Harvey Pendell , Zaimi (Petrela) Elizana , Smith Stephen W.
Published: July 2024

Forty percent of patients with acute coronary occlusion myocardial infarction (OMI) do not present with STEMI criteria, which delays their treatment and increases morbidity and mor-tality. The need to identify these patients promptly is crucial, and this sets the stage for the pro-posed reclassification. Many of these patients can be identified by other ECG and clinical fea-tures. Background/Objectives: We sought to evaluate STEMI/NSTEMI cases that result in OMI and the consequences of delayed revascularization immediately among NSTEMI patients who have ACO (NSTEMI-OMI). Methods: The study is a retrospective analysis conducted on 334 pa-tients who underwent coronary angiography for acute coronary syndrome at UHC ‘‘Mother Te-resa,’’ Tirana, Albania, during January-May 2023. OMI was defined as an acute culprit lesion with TIMI 0-2 flow, or TIMI 3 flow with highly elevated troponin (cTnI>10.0 ng/mL, hs-cTnI>5000 ng/L). Ejection fraction (EF), total ischemia time, hospital day stay and complications were com-pared between groups. Results: There were 334 patients included of whom NSTEMI-OMI were 98 patients (29.3%) of patients with ACS. 96 patients (40%) of OMI patients did not fulfill the STEMI criteria. Only 11 patients (11%) of STEMI(-)OMI had PCI performed within the first 12 hours vs 76 patients (77%) of STEMI(+)OMI, p<0.001. There was no difference in the percent of patients requiring PCI between the STEMI(+)OMI 98 patients (93%) and STEMI(-)OMI 87 patients (89%) (p<0.001). The overall in-hospital mortality was 19 patients (5.7 %), with subgroup mortality of 14 patients (4.2%) STEMI(+)OMI, two patients (0.6%) STEMI(+) NOMI, three patients (0.9%) STEMI(-)OMI, 0% STEMI(-)NOMI, (p=0.013). Patients with mechanical complications were: 67 patients (46.8%) STEMI(+)OMI and 45 patients (46.4%) STEMI(-)OMI. 26 patients (18.5%) STEMI(+)OMI and 13 patients (13.1%) STEMI(-)OMI developed electrical complications. Conclusions STEMI(-)OMI patients had significant delays in catheterization, yet had angiographic findings, rate of PCI, and complications similar to STEMI(+)OMI. These data add further support to refocusing the paradigm of acute MI to improve recognition and rapid reperfusion of all OMIs, rather than only those with STEMI criteria.
The First VHE Activity of OJ 287 and the Extragalactic Background Light
Authors: Yadav Sameer , Kushwaha Pankaj
Published: July 2024

The BL Lacertae (BL Lac) object OJ 287 underwent an intense X-ray activity phase, exhibiting its brightest recorded X-ray flare in 2016-2017, characterized by much softer X-ray spectra and, concurrently, its first-ever recorded very-high-energy (VHE) emission (100--560 GeV), reported by the VERITAS observatory. Broadband spectral energy distribution reveals a new jet emission component similar to high-synchrotron-peaked BL Lac objects, thereby implying the soft X-ray spectrum for the synchrotron emission. Using the advantage of simultaneous X-ray and VHE spectral information, as well as the source being a low-synchrotron-peaked BL Lac object, we systematically explored the extragalactic background light (EBL) spectrum by demanding that the VHE spectrum cannot be harder than the X-ray spectrum. We used three different phenomenological forms of the EBL spectral shape (power-law, parabola, and polynomial) motivated by current constraints on the EBL with the Bayesian Monte Carlo approach to infer the credible EBL range. Our study favors an almost flat power-law spectral shape and is consistent with previous studies. The other spectral forms capable of capturing curvature though result in a better statistics value; the improvement is statistically insignificant given the additional parameters.
Altered Parkin and Bcl-2 Expression Suppresses Drp1 Gain and Loss of Function Age-Related Phenotypes in Drosophila
Authors: Hasan Azra , Staveley Brian Ernest
Published: July 2024

The relationship of Amyotrophic Lateral Sclerosis, Parkinson Disease and other age-related neurodegenerative diseases associated with mitochondrial dysfunction has led to study of the mitochondrial fission gene Drp1 in Drosophila. Drp1 can interact with mitochondrial proteins including parkin and the Drosophila Bcl-2 proteins. Mutations in Drp1 can lead to mitochondrial dysfunction and neuronal loss. Ddc-Gal4 was exploited to direct the expression of Drp1 and the inhibition of Drp1 in neurons. Here, the inhibition of Drp1 seems to compromise locomotor function throughout life but does not alter longevity. The consequences of Drp1 overexpression can be suppressed through overexpression of pro-survival Bcl-2 gene Buffy or by inhibition of the pro-cell death Bcl-2 homologue Debcl. The expression of Buffy suppresses the poor climbing induced by loss of Drp1 function. Interestingly, the loss of parkin function is rescued by the directed inhibition of Drp1. Alteration of the expression of Drp1 acts to phenocopy neurodegenerative disease phenotypes in Drosophila, while overexpression of Buffy can counteract these phenotypes to improve overall health. The pro-survival effect of Buffy can rescue the phenotypic effect due to the Drp1-induced apoptosis. The diminished health due to either overexpression or inhibition of Drp1 has produced a novel model to investigate mechanisms underlying neurodegenerative disease.
Pectin Remodeling and Involvement of AtPME3 in the Parasitic Plant-Plant Interaction Arabidospis thaliana – Phelipanche ramosa
Authors: Grandjean Cyril , Veronesi Christophe , Rusterucci Christine , Gautier Charlotte , Maillot Yanis , Leschevin Maïté , Fournet Françoise , Drouaud Jan , Marcelo Paulo , Zabijak Luciane , Delavault Philippe , Simier Philippe , Bouton Sophie , Pageau Karine
Published: July 2024

Phelipanche ramosa is a root parasitic plant fully dependent on host plants for nutrition and development. Once germinated, the parasitic seedling develops inside of the infected roots a specific organ, the haustorium, thanks to notably cell wall degrading enzymes of haustorial intrusive cells and induced modifications in host’s cell walls. The model plant Arabidopsis thaliana is susceptible to P. ramosa, thus mutants in cell wall metabolism, notably in pectin remodeling like Atpme3-1, are of interest in studying the involvement of cell wall degrading host’s enzymes in establishment of the plant-plant interaction. Host-parasite co-cultures in mini-rhizotrons systems revealed that parasite attachments are twice more numerous and tubercle growth is quicker on Atpme3-1 roots than on WT roots. When compared to the WT, increase in susceptibility in the mutant is associated to reduction in PME activity in roots and to lowering in the degree of pectin methylation at the host-parasite interface, as detected immunohistochemically in infected roots. In addition, both WT and Atpme3-1 responded to infestation by modulations in expression of PAE and PME encoding genes and in global related enzymes activities in roots, before and after parasite attachment. However, modulations differ in WT and Atpme3-1 and this may contribute to different pectin remodeling in roots and contrasted susceptibility to P. ramosa. By this integrative study, we could define a model of the cell wall response to this particular biotic stress and indicate for the first time the role of PME3 in this parasitic plant-plant interaction.
Herpes Simplex Virus 1 Infection of Human Brain Organoids and Pancreatic Stem Cell-Islets Drives Transcripts Associated with Alzheimer’s Disease and Autoimmune Diseases
Authors: Sundstrom Jonathan , Vanderleeden Emma , Barton Nathaniel J , Redick Sambra D , Dawes Pepper , Murray Liam F , Olson Meagan N , Tran Khanh , Chigas Samantha M , Orszulak Adrian R , Church George M , Readhead Benjamin , Oh HyungSuk , Harlan David M , Knipe David M , Wang Jennifer P , Chan Yingleong , Lim Elaine T
Published: July 2024

Viral infections leading to inflammation have been implicated in several common diseases such as Alzheimer’s disease (AD) and type 1 diabetes (T1D). Of note, herpes simplex virus 1 (HSV-1) has been reported to be associated with AD. We sought to identify the transcriptomic changes due to HSV-1 infection and anti-viral drug (acyclovir, ACV) treatment of HSV-1 infection in dissoci-ated cells from human cerebral organoids (dcOrgs) versus stem cell-derived pancreatic islets (sc-islets) to gain potential biological insights into the relevance of HSV-1-induced inflammation in AD and T1D. We observed that differentially expressed genes (DEGs) in HSV-1-infected sc-islets were enriched for genes associated with several autoimmune diseases, most significantly T1D but also rheumatoid arthritis, psoriasis, Crohn’s disease, and multiple sclerosis, whereas DEGs in HSV-1-infected dcOrgs were exclusively enriched for genes associated with AD. ACV treatment of sc-islets did not rescue transcript expression of autoimmune disease-associated genes. Finally, we identified gene ontology categories that were enriched for DEGs that were in common across, or unique to, viral treatment of dcOrgs and sc-islets, such as categories involved in the transferase complex, mitochondrial and autophagy function. Collectively, this studies pro-vide insight to the molecular effects of inflammation in AD and T1D.
Personalized Management of Patients With Proliferative Diabetic Vitreo-Retinopathy
Authors: Szabo Dorottya , Ecsedy Monika , Szilagyi Zsuzsa , Nagy Zoltan Zsolt , Recsan Zsuzsanna
Published: July 2024

Purpose: To evaluate prognostic factors for visual outcome in patients with diabetes who have undergone vitrectomy (PPV) for severe proliferative diabetic vitreo-retinopathy (PDVR) in at least one eye in the past 15 years. Methods: Medical records of 132 eyes of 66 patients were analyzed (median age 52ys 21-80; patients with type 1/2 diabetes 40/26, median follow-up 38 months 9-125). Correlation between final good visual outcome defined as 0.5≤ best corrected visual acuity (BCVA) and prognostic factors (age, sex, type and duration of diabetes, metabolic status, BCVA, diabetic retinopathy status, data of preoperative management, data of vitrectomy, postoperative complications) were analyzed. Results: BCVA improved significantly in the entire study cohort (from median 0.05 min-max 0.001-1 to 0.32 0.001-1, p <0.000). Visual stabilization was achieved in the majority of patients, and relatively good visual acuity (0.5≤BCVA) was maintained in more than one third of eyes. Multivariable GEE statistics showed that in addition to duration of diabetes and stable HbA1c values, only preoperative tractional macular detachment proved to be an independent significant predictor of visual outcome. Conclusions: Pars plana vitrectomy is a useful tool when performed early before tractional macular detachment. However, long-term visual stability can only be achieved with good metabolic control.
Studying some Inequalities involving Polynomial Functions in π(x)
Authors: De Subham
Published: July 2024

This article serves as a extensive research into proposing a few significant inequalities involving polynomial functions in $\pi(x)$, the \textit{prime counting function}, with an intention of exploring the behaviour of $\pi(x)$ for increasing $x$. The general case for such polynomials has also been discussed in detail towards the later section of the article, where the primary focus was to study the order of polynomials of the form, \begin{align*} P(\pi(x)) - \frac{e x}{\log x} Q(\pi(x/e)) + R(x) \end{align*} $P$, $Q$ and $R$ being arbitrary polynomials, and establish for a particular case that, the polynomial yields negative values for sufficiently large values of $x$. Furthermore, the error term in such estimations is of order $O\left(\frac{x^d}{(\log x)^{d+1}}\right)$, $d$ depends heavily upon $deg(P)$ and $deg(Q)$.
Relationship of healthy vascular aging with the Mediterranean diet and other lifestyles in the Spanish population. EVA Study.
Authors: Gómez-Sánchez Leticia , Gonzalez-Falcon David , Llamas-Ramos Rocio , Cortes-Rodriguez María , Rodríguez-Sánchez Emiliano , García-Ortiz Luis , Llamas-Ramos Ines , Gómez-Sánchez Marta , Gómez-Marcos Manuel A.
Published: July 2024

The aim of this study was to analyze the relationship between healthy vascular aging (HVA) and the Mediterranean diet alongside other lifestyles in a Spanish population aged 35 to 75 years without previous cardiovascular diseases. Methods: Cross-sectional descriptive study with 501 individuals aged 35 to 75 years recruited from five health centers by random sampling stratified by age and sex (55.90±14.24 years, 49.70% men). HVA was determined in two steps. Step 1: Subjects with vascular damage to the carotid arteries or peripheral arterial disease were classified as non-HVA. Step 2: The study population was classified by age and sex using the percentiles of the vascular aging index (VAI), with VAI ≤p25 considered HVA and >p25 considered non-HVA. The VAI was estimated using the following formula (VAI = (log (1.09) × 10 cIMT + log (1.14) cfPWV) × 39.1 + 4.76. Carotid-femoral pulse wave velocity (cfPWV) was measured with the SphygmoCor® device and carotid intima-media thickness using Sonosite Micromax® ultrasound. Mediterranean diet (MD) adherence, alcohol and tobacco use were recorded through validated questionnaires. Physical activity was assessed with the ActiGraph-GT3X® accelerometer. Results: The mean VAI value was 61.23±12.86; (Men 63.47±13.75 and women 59.04±11.54; p
Parallel PSO for the Efficient Training of Neural Networks Using the GPGPU and Apache Spark in an Edge Computing Environment
Authors: Capel Manuel I. , Salguero-Hidalgo Alberto , Holgado-Terriza Juan Antonio
Published: July 2024

Deep learning neural networks require an immense amount of computation, especially in the training phase of the network when networks with multiple layers of intermediate neurons need to be built. In this paper, we will focus on the PSO algorithm with the aim of significantly accelerating the DLNN training phase by taking advantage of the GPGPU architecture and the Apache Spark analytics engine for large-scale data processing tasks. PSO is a bio-inspired stochastic optimization method whose goal is to iteratively improve the solution to a (usually complex) problem by attempting to approximate a given objective. However, parallelizing an efficient PSO is not a straightforward process due to the complexity of the computations performed on the swarm of particles and the iterative execution of the algorithm until a solution close to the objective with minimal error is achieved. In the present work, two parallelizations of the PSO algorithm have been implemented , both designed for a distributed execution environment. The synchronous parallel PSO implementation ensures consistency at the cost of potential idle time due to global synchronization, while the asynchronous parallel PSO approach improves execution time by reducing the need for global synchronization, making it more suitable for large datasets and distributed environments such as Apache Spark. Both variants of PSO have been implemented to distribute the computational load supported by this algorithm –due to the costly fitness evaluation and updating of particle positions– across the different Spark cluster executor nodes to effectively achieve coarse-grained parallelism, resulting in a significant performance increase over current sequential variants of PSO.
Rare Earth Element Content in Hair Samples of Children Living in the Vicinity of the Kola Peninsula Mining Site and Nervous Systems Diseases
Authors: Belisheva Natalia , Drogobuzhskaya Svetlana
Published: July 2024

The aim of this study is to assess of rare earth elements (REE) content in hair samples in children, living in Lovozero village, near REE mining site, and possible effects of REEs on the prevalence of nervous system diseases in the Lovozersky district (Murmansk region, Kola Peninsula). School-age children (53 persons) were recruited for analysis of REE content in their hair samples. REEs (Y, La, Ce, Pr, Nd, Sm, Eu, Gd, Tb, Dy, Ho, Er, Tm, Yb, Lu) content was estimated by inductively coupled plasma mass spectrometry (ICP-MS). Analysis of REE content in the hair of children living in the Russia, Kazakhstan and China indicates REEs intake from environment. A possible contribution of REEs to the nervous system disorders is supported by the link between REE content in the hair samples of children, living near REE mining (China) and by manifesting cognitive disorders in these children. It also turn out that highest prevalence of the nervous system diseases in children 15-17 years old manifested in the Lovozersky district then in other area in the Murmansk region. The paper discusses the possible contribution of REEs to the prevalence of episodic paroxysmal disorders (G40-G47), cerebral palsy (G80-G83), epilepsy and status epilepticus (G40-G41).
Utilization of Tofu Liquid Waste as Liquid Organic Fertilizer Using the Fermentation Method with Activator Effective Microorganisms 4 (EM-4): A Review
Authors: Kurniawan Lutfi , Maryudi Maryudi , Astuti Erna
Published: July 2024

ABSTRACT. Liquid organic fertilizer is organic fertilizer in liquid form which is partly or wholly derived from organic compounds such as plant, animal and industrial residues, in solid or liquid form. The nutrients contained in it are in the form of a very fine solution so that it is easily absorbed by plants, even the leaves or stems. Organic fertilizer is one solution to restore soil minerals physically, chemically and biologically from the bad effects of synthetic fertilizers. Liquid fertilizer is obtained from a solid fermentation process first, then followed by a liquid anaerobic fermentation and extraction process. In the fermentation process, the role of microbes greatly determines the product produced. Tofu liquid waste is made from cooking residue from cooked soybeans boiled and the water from the remaining tofu tends to be thrown into the surrounding environment. Waste Liquid tofu contains organic ingredients, namely carbohydrates reaching 20-50%, protein 40-60%, and 10% fat. It is known that this tofu waste can be used as liquid organic fertilizer by fermentation. Tofu liquid waste contains organic substances, namely carbohydrates, proteins and fats, which can be used as liquid organic fertilizer. These substances must first be broken down into simpler elements by a fermentation process so that they can be absorbed by plants. Effective Microorganisms-4 as inoculants to increase microbial diversity in soil and can control unpleasant odors, accelerate the decomposition process, maximize the decomposition process, increase nutrient content, reduce the growth of pathogenic microorganisms, improve the physical, chemical and biological structure of the soil and bioremediation.

Keywords: 

Liquid Organic Fertilizer, Liquid Waste, Fermentation, Effective Microorganisms-4, Nutrient
Optimal distribution of limited resource in a context of uncertainty
Authors: Raskin Lev , Sukhomlyn Larysa , Hatunov Artur , Andriienko Serhii
Published: July 2024

Object of research: methods of rational distribution of limited resource in a context of uncertainty. It is assumed that the system consists of a set of independently functioning elements, and effectiveness of these elements depends on the level of investment. The complexity of solving the problem using traditional methods depends on and is determined by the type of analytical description of production functions of the system elements. Significant difficulties arise if parameters of production functions are uncertain quantities, specified, for example, in terms of fuzzy mathematics. This circumstance emphasizes the relevance of studying approaches to solving the set problem of resource distribution for the case when its parameters are not clearly defined, and this circumstance also determines the goal of the work. Problems arising from the goal consist in developing mathematical models and methods for rational resource distribution for the main types of production functions with their parameters being fuzzy numbers of (L –R) type. To solve these problems, a method is proposed that transforms the original fuzzy problems into clear ones that can be solved using standard constrained optimization technologies. An important result of the research consists in the fact that the proposed method is universal, that is, it is applied in the same way to solve problems of resource distribution in systems wherein production functions of the elements can be of arbitrary nature. Refs.: 11 titles.
Models for diagnosing interactive computer networks at the structural and logical level
Authors: Miroshnyk Maryna , Koroleva Yana , Demenkova Svitlana , Shafranskyi Andrei
Published: July 2024

Methods of diagnosing interactive computer networks at the structural and logical level are developed. Methods and procedures for synthesizing one-dimensional and two-dimensional networks with distributed configuration control are developed. The existing methods of diagnosing interactive computer networks at the structural and logical level have been analyzed. Diagnostics models for interactive computer networks at the structural and logical level have been created. According to the results of diagnostic experiments the conclusion about testability of the networks considered in the paper is made. 4 figures, 7 bibliographic sources. Figs.: 4. Refs.: 14 titles.
Application of Siamese neural networks to compare aerial photographs with terrain maps
Authors: Vlasenko Vitalii
Published: July 2024

The work presents the methodology for the development and training of the Siamese neural network for comparing aerial photographs with terrain maps. The proposed approach is aimed at identifying stable and informative features in images, which allows to increase the accuracy and automation of the matching process. The presented method uses two identical networks that are trained in parallel, which ensures a reduction in the gap in characteristics between the compared images. The Siamese neural network efficiently handles images of varying quality and detail, making it ideal for comparing aerial photographs with terrain maps. The developed tool allows for quick analysis and comparison of aerial photographs with terrain maps with high efficiency and accuracy, which contributes to the expansion of the field of application in geoinformation research and engineering applications. Figs.: 3. Refs.: 11.
Among the new social actors
Authors: Syrodeeva Asya ,   RAS Institute of Philosophy
Published: July 2024

Against the dynamic background that distinguishes modern social reality, the formation of specific social entities is clearly visible. The basis for their emergence are certain ideas. Such tendency in itself is not historically unusual. And yet it is worth paying attention to the fact that in the age of information technologies, the “ideas” factor in terms of importance has increased significantly. Such a trend should lead to the growth in the influence, social status of those strata, groups, individuals who are related to the social functioning of ideas. However, the peculiarity of the current context is that information technologies affect not only and not so much those who work with an ideal component, but society in all its diversity. Information technologies contribute to democracy and transparency in the social circulation of ideas at the stages of production, distribution and consumption. In the age of the Internet, ideas are under the additional public and individual control of doubt, criticism. Thanks to this, they manage to unite very different people, and at the same time support them in striving for personal independence.
Dá zoom na imagem: configurações interacionais experimentadas no contexto escolar durante a pandemia da COVID-19
Authors: Cruz Fernanda Miranda da , Baldan Rosana Kelly , Sellito de Melo Vitória
Published: July 2024

Este artigo analisa encontros de atendimento educacional especializado (AEE) que aconteceram em agosto de 2020. Os encontros foram registrados em vídeo e deles participam uma professora, uma estudante autista e a mãe da estudante. Desafios e impactos no contexto escolar emergencial remoto serão discutidos a partir de uma análise linguística e interacional de ordem microanalítica. Essa perspectiva oferece instrumentos para descrever as configurações socionteracionais, algumas delas inéditas, tais como: a) novas contingências espaciais e materiais; b) a interação por meio de tecnologias, que colocou os corpos em copresença temporal e situacional, mas espacial e fisicamente distantes e c) a participação de familiares em interações que eram, até então, reservadas ao professor-aluno(s). Em uma espécie de zoom dado a instantes de interações, as análises mostram como as três participantes vivenciaram e gerenciaram um conjunto de acontecimentos que habitavam uma macroesfera da pandemia, como alterações de estados emocionais da estudante autista (mas também de professores e pais); adaptação da estudante a uma nova rotina; confronto com problemas práticos relacionados à tecnologia; presença inédita de familiares durante as aulas.
As fake news e o conhecimento linguístico – um contributo para uma reflexão sobre uma perspectiva didática
Authors: Teixeira Maria Madalena Teles de Vasconcelos Leite Dias Ferreira e , Freire da Silva Oliveira Lucas Sávio , Gomes São Marcos Simões Ana Raquel
Published: July 2024

A pandemia da covid-19 alterou significativamente as estruturas de funcionamento das sociedades. Como uma das muitas transformações, assistiu-se a um aumento da produção e da disseminação de fake news (FN), sobretudo relacionadas com o surgimento e propagação da doença. Neste contexto, o Outro, por sua vez, tornou-se protagonista do papel de agente responsável pelos efeitos negativos associados a este cenário pandémico – panorama em que a linguagem desempenhou importante função, já que os processos de alterização (otherization) e de estereotipização se revelam através da execução dos seus mecanismos. Assim, considerando o impacto deste cenário na educação, este trabalho visa contribuir para uma reflexão sobre um ensino articulado entre a gramática e a escrita, a partir da análise de duas FN – recolhidas em abril de 2020 – que relacionam as consequências da covid-19 com grupos minoritários, e que integram o projeto europeu CoMMiTTEd (2021). Essencialmente, pretendeu-se verificar o uso de algumas classes de palavras na construção dos discursos presentes nas FN. Os resultados analisados revelam que o uso de nomes, verbos e adjetivos evidenciam a busca de credibilidade das FN e de impacto no leitor, facilitando o processo de assimilação por parte deste, o que parece, assim, justificar a necessidade de uma didática articuladora da gramática e da escrita.
Estrutura de um dicionário enciclopédico do novo coronavírus organizado com base na semântica cognitiva lexical: apontamentos sobre o domínio SAÚDE
Authors: Oliveira Ana Flávia Souto de , Echevarria Camile Heinrich
Published: July 2024

Neste trabalho, é apresentada e discutida a estrutura utilizada na compilação de um dicionário enciclopédico sobre o novo coronavírus. O LEXICOVID-19 (Oliveira et al., 2020) é uma obra inserida em um corpo de trabalhos que tem como premissa aproximar o aparato teórico-metodológico da Semântica Cognitiva da compilação de obras de referência. As noções de conhecimento enciclopédico (Langacker, 2008; Fillmore, 1982), domínio (Langacker, 2008) e frame (Fillmore, 1982) subsidiam a organização da estrutura de acesso da obra, a composição de três microestruturas e a seleção das categorias informacionais do dicionário. O domínio SAÚDE é utilizado para problematizar as questões teóricas e metodológicas envolvidas na compilação da obra. Destacam-se, como contribuições da Semântica Cognitiva para a Lexicografia, as possibilidades de interação entre informações linguísticas e informações de mundo, necessárias à descrição do léxico da pandemia na era da informação digital.
Práticas de lexicografia crítica na sala de aula
Authors: Elias de Oliveira Sheila
Published: July 2024

Este artigo discute o papel formador de projetos de dicionários realizados em sala de aula durante a pandemia de covid-19, inscritos no que a autora denomina “lexicografia crítica”. A discussão é guiada por uma concepção de linguagem filiada ao materialismo histórico, na qual se assume a indissociabilidade entre linguagem, subjetividade e sociedade. Ancorada nessa concepção, a autora defende que o exercício da lexicografia crítica por linguistas e professores de língua em formação pode possibilitar ou mesmo fomentar uma leitura ativa dos dicionários, uma escrita autoral e uma reflexão sobre a inscrição material da subjetividade na língua.
Ischemia-modified albumin: Is it a promising marker in acute coronary syndrome?
Authors: Ralapanawa Udaya , Sivakanesan Ramiah , Tennakoon Sampath , Karunathilake Parackrama
Published: July 2024

Background
Acute coronary syndrome (ACS) is a type of coronary heart disease (CHD), which is responsible for one-third of total deaths in people older than 35 years. Even though cardiac troponin is the gold standard for myocardial necrosis it is blind for ischemia without necrosis. Studies demonstrate that IMA is more sensitive in diagnosing ischemic chest pain compared to cardiac troponin T and electrocardiogram, and its combination with these tests significantly increases the sensitivity for diagnosing unstable angina, NSTEMI, or STEMI, with high positive and negative predictive values, making it a valuable tool for ruling out ACS in patients with inconclusive diagnoses in the emergency department.
Methods and Findings
This prospective cohort study, conducted at the Teaching Hospital, Peradeniya, Sri Lanka, from 2015 to 2019, investigated ischemia-modified albumin (IMA) levels in 330 acute coronary syndrome (ACS) patients. Excluding those with various chronic conditions and those on specific medications, serum IMA was analysed using a colorimetric assay based on cobalt (II) binding to human serum albumin affected by myocardial ischemia. The study found a significant right skew in IMA distribution, confirming its non-normality. No overall significant gender-based difference in IMA levels was observed, though within the younger age group (< 59 years), males exhibited higher IMA concentrations than females. Ethnicity and age appeared to have limited impact on IMA levels. Notably, a significant gender difference in IMA levels was found in obese patients, suggesting physiological differences in response to obesity. The study also revealed higher IMA concentrations in NSTEMI and STEMI patients compared to those with unstable angina. A significant positive correlation between serum IMA levels and lipid profiles, particularly LDL-cholesterol, was established, indicating a link with dyslipidaemia.
Conclusion
The findings suggest the potential of IMA as a multifaceted biomarker in ACS diagnosis and prognosis, emphasizing the need for personalized medicine approaches and highlighting the role of lipid management in ACS risk reduction.
Dengue virus type 3 infection in a traveler returning from Costa Rica to Japan in 2023
Authors: Sasaki Tadahiro , Morita Ryo , Aoyama Ikuko , Baba Takashi , Goto Tetsushi , Kubota-Koketsu Ritsuko , Samune Yoshihiro , Nakayama Emi E. , Shioda Tatsuo , Shirano Michinori
Published: July 2024

Background:
The number of dengue cases has increased dramatically in recent years. In Latin America, the number of cases and deaths in 2023 was the highest ever recorded. We report on a patient who had been infected with dengue virus during his stay in Costa Rica in September 2023, and developed the disease after returning to Japan.
Methods:
Plasma obtained from the patient was used for diagnosis and dengue virus serotyping by real-time PCR. The nucleotide sequence of the envelope region of dengue virus was then determined by the direct sequencing method, and this sequence was used for phylogenetic analyses.
Results:
The patient was infected with dengue virus type 3 genotype III. The sequence from the present case was more homologous with sequences registered in Florida, U.S. in 2023 than with sequences registered in Costa Rica 10 years ago. The Pan American Health Organization reported that only dengue virus type 1 and 2 cases were reported in Costa Rica in 2019-21, while dengue virus type 3 and 4 cases started being reported in 2022. In 2023, the reported numbers of dengue virus types 3 and 4 cases were more than those of dengue virus types 1 and 2. In addition, regional differences in endemic strains have been observed in Costa Rica.
Conclusion
Our findings suggest that the dengue virus type 3 that infected the patient was not a re-emergence of an indigenous virus in Costa Rica, but was more likely an imported strain that had been endemic in Cuba in recent years. The serotypes of dengue virus prevalent in Costa Rica have been changing since 2022. All four serotypes were prevalent in 2023, with a particularly sharp increase in the number of cases of dengue virus types 3 and 4. Future monitoring and surveillance are essential because changes in endemic serotypes can cause antibody dependent enhancement, which can lead to severe dengue disease presentations.
A Modern Comparison of Suture Repair versus Mesh Repair for Incisional Hernia: A Study Protocol for a Randomized Controlled Trial
Authors: Maskal Sara , Miller Benjamin T , Ellis Ryan C , Beffa Lucas R.A. , Prabhu Ajita S. , Rosen Michael J , Krpata David M. , Huang Li-Ching , Petro Clayton C
Published: July 2024

Background: The utilization of mesh is considered the standard of care for incisional hernia repairs to reduce recurrence. However, mesh complications – including infection and enterocutaneous fistulae – can impact patients’ quality of life and culminate in reoperation. Meanwhile, techniques for fascial closure and our understanding of abdominal wall tension physiology have improved since the original studies comparing suture and mesh-based ventral hernia repairs were published, but there have been no contemporary trials comparing these approaches since the evolution of fascial closure techniques.
Methods: This is a registry-based, multicenter, patient-blinded randomized controlled trial designed to investigate whether a suture-only technique utilizing a posterior rectus sheath release, small bite technique and 4:1 closure is noninferior to a retrorectus mesh-based repair for clean, incisional hernias that are 2-6cm in width. The primary study endpoint is abdominal wall-specific quality of life (HerQLes) at one year postoperatively. Our primary hypothesis is that suture-based incisional hernia repair will be non-inferior to mesh-based repairs with respect to HerQLes summary score at one-year postoperatively. Secondary outcomes of interest include hernia recurrence at 1, 2, and 5-years postoperatively, pain as measured by the PROMIS-3a Pain Intensity survey, cost-effectiveness ratios, 30-day readmissions, wound complications, and reoperations. Additional outcomes include hernia recurrence, patient-reported quality of life, wound complications, hernia-related reoperation at 30-days, 1-year, 2-years, and 5-years.
Discussion: The risks of mesh-related complications, coupled with the lack of contemporary data, warrant new investigation into the necessity of mesh placement for all incisional hernias.
Trial registration: NCT05599750. Registered on October 26, 2022.
Charcot neuroarthropathy due to Congenital Insensitivity to Pain With Anhidrosis: A case report and literature review
Authors: Hu Yunan , Zhang Lei , Zhu Yanlin , FU Weili
Published: July 2024

Background
Charcot neuroarthropathy (CN) is a systemic disorder characterized by pathological changes in the musculoskeletal system, leading to fractures, dislocations, and deformities of multiple bones and joints. While diabetes mellitus, leprosy, sickle cell disease, poliomyelitis, and chronic alcoholism are common underlying causes of CN, it has also been associated with Congenital insensitivity to pain with anhidrosis (CIPA). Nevertheless, there are fewer reports of such diseases and a single treatment modality. This paper presents a case of a a 13-year-old girl diagnosed with bilateral Charcot neuroarthropathy combined with congenital insensitivity to pain with anhidrosis. This study discusses the pathophysiology, diagnostic and therapeutic approaches and reviews the relevant literature.
Case presentation
We reported a case of a 13-year-old girl with Charcot neuroarthropathy (CN) of the left knee joint, which was secondary to congenital insensitivity to pain with anhidrosis (CIPA). She suffered an unexplained fracture of the left phalanx 2 months after birth, and subsequently, multiple fractures occurred repeatedly throughout her body, primarily in the weight-bearing bones of the lower limbs. Two years prior to presentation, she experienced recurrent swelling of the left knee joint after hiking. Since that episode, her left knee joint continued to swell repeatedly. We established arthroscopic approaches to the left knee, debrided the hyperplastic synovial tissue, opened the joint capsule at the posterior aspect of the knee joint, removed the posterior loose body of the medial femoral condyle with a medullary forceps, and then debrided the damaged cartilaginous surface and intra-articular debris with a paring knife. At present, the overall treatment outcome is satisfactory, and she remains under follow-up observation.
Conclusions
Adolescent patients can be treated with good outcomes after undergoing left knee arthroscopy. Understanding the potential determinants, health risks, and complications associated with CIPA progression helps surgeons make informed decisions for their patients. Currently, the overall treatment outcome is satisfactory, and she is still under follow-up observation.
First characterization of cultivable skin bacteria in the synanthropic anuran Scinax x-signatus (ANURA: HYLIDAE) in northeast Brazil
Authors: Santos Lara Valesca Mendonça da Costa , Santos Alcina Gabriela Maria Medeiros da Fonsêca , de Souza Paula Mariana Salgueiro , Almeida Anna Carolina Soares , de Moura Geraldo Jorge Barbosa
Published: July 2024

Some amphibians’ species adapted to the urban ecosystem – synanthropic - can have their cryptic interactions with microorganisms altered. In the case of anurans, the skin bacterial microbiota plays a fundamental role in host protection. However, it is not known how the composition and diversity of the skin microbiota of Scinax x-signatus, a synanthropic anuran, behaves in different fragments. In this study, we describe the culturable bacteria from the skin of individuals of the anthropic anuran Scinax x-signatus by sequencing the 16S rRNA gene obtained from the amplified product of polymerase chain reaction (PCR) technique. Skin swab samples were collected from 11 S. x-signatus, 4 in a natural area and 7 in an anthropized area. Bacteria were isolated using different rich and selective culture media. A total of 20 bacterial isolates were identified, being 7 in control area and 13 in anthropized area, represented by the families Enterobacteriaceae (54.6%; n = 7), Bacillaceae (18.2%; n = 2) and Moraxellaceae (18.2%; n = 2). Among their representatives, we report Enterobacter as the most frequent genus and highlight the first report of Escherichia coli. This first report of culturable skin bacteria of Scinax x-signatus, together with the first record of E. coli, improves our knowledge of the skin microbiome of amphibians, contributing to their conservation and the maintenance of environmental health.
Ectopic thyroid carcinoma in central airway with normally located goiterous thyroid gland: A case report
Authors: LI Cai-li , ZHOU Wei , CHEN Mo , LI Shuo , CHEN Bao-yuan , FENG Jing
Published: July 2024

Background: ectopic thyroid tissue is a developmental disorder and is extraordinarily rare to occur in the central airway. To our knowledge, nearly few reports of primary ectopic thyroid carcinoma in the central airway with a normal eutopic thyroid gland have been published to date. This is the second case about malignant central airway obstruction caused by primary ectopic thyroid carcinoma.
Case presentation: 65-year-old male was admitted to hospital for coughing accompanied by wheezing that recent exacerbated at night.The chest computed tomography scan revealed a soft tissue-density mass within the central trachea.The mass was removed and pathological analysis showed that it was ectopic thyroid carcinoma surprisingly. The goitrous thyroid gland was found in its expected location.
Conclusion: Ectopic thyroid carcinoma should be considered in the differential diagnosis of a pathological mass located in central airway.
Comparing Myocardial Perfusion Scan Findings in Patients With and Without Covid-19
Authors: Moasses-Ghafari Bahar , Choupani Sahar , Jahanbin Sajed , Lotfi Reza , Rahmani Khaled
Published: July 2024

Background and aim:
Covid-19 is a pandemic viral disease involving multi organ systems including cardiovascular system, directly or indirectly. SPECT GATED MPI is a non-invasive nuclear medicine imaging modality to evaluate the myocardial perfusion and function. The aim of this study was to assess the effect of Covid-19 pandemic on myocardial perfusion imaging for ischemic heart disease.
Methods This was a cross-sectional (descriptive-analytical) study conducted on 750 patients needing myocardial perfusion imaging (MPI) who referred to the nuclear medicine center of Kowsar hospital, a teaching hospital in Sanandaj, the center for Kurdistan province located in northwest of Iran. Data collection was done during the Covid-19 pandemic, between 6 April 2020 and 21 March 2021. Data analyses were conducted in SPSS using independent sample T test and Chi-square.
Results A total of 750 patients, including 328 (43.7%) Covid-19 positive and 422 (56.3%) Covid-19 negative, were entered in the analysis. Although Covid-19 infected Obese patients had significantly higher rate of abnormal MPI (P< 0.0001), no significant difference was observed between the two groups regarding abnormal MPI (p=0.551).
Conclusion The absence of a significant discrepancy in abnormal MPI occurrence between the two groups suggests that there may be Covid-19 patients with potentially abnormal MPI who have gone undetected. Additionally, Covid-19 patients with pleural chest pain, myalgia, or dyspnea could have been misdiagnosed with chest pain secondary to heart disease.
Case Report: Neonatal Presentation of Congenital Adrenal Hyperplasia Accompanied by Isolated Cleft Palate
Authors: SAKA SULYMON AYOBAMI
Published: July 2024

Introduction: Congenital adrenal hyperplasia (CAH), particularly due to 21-hydroxylase deficiency, is an autosomal recessive disorder characterized by impaired cortisol synthesis, leading to severe clinical manifestations such as adrenal crises and atypical genitalia in 46,XX neonates. Isolated cleft palate (ICP) is a congenital anomaly resulting from incomplete palatal shelf fusion and is influenced by genetic and environmental factors. Concurrent presentations of CAH and ICP are extremely rare.
Case Presentation: Here, we report the case of a 19-day-old neonate born to Nigerian parents who presented with ambiguous genitalia and cleft palate. Initial evaluations revealed hyperkalaemia, hyponatremia, and metabolic acidosis, indicative of salt-wasting CAH. Genitourinary examination revealed partial labioscrotal fold fusion, clitoromegaly, and the absence of vaginal opening. Despite financial limitations restricting comprehensive diagnostic tests, the diagnosis of CAH was supported by clinical findings and initial laboratory results. The neonate received appropriate treatment for hyperkalaemia and hormone deficiencies. Multidisciplinary consultations were sought for the management of both CAH and ICP.
Conclusion: This case highlights the rare co-occurrence of CAH and ICP, emphasizing the importance of a multidisciplinary approach for effective management. This underscores the necessity for early diagnosis and integrated care to improve patient outcomes. Further research is warranted to explore potential associations and enhance the clinical understanding of such complex congenital anomalies.
Classification of cases of pre-eruptive intra-coronal resorption
Authors: Naicker Jade , Smit Chané , Uys Andre
Published: July 2024

Introduction
Resorption mechanisms triggered in teeth can lead to lesions, especially in instances of impacted dentition. Evidence of these lesions can be detected via radiographic imaging and are often classified as pre-eruptive intra-coronal resorption (PIR). These resorptive lesions do not typically present with symptoms of pain or discomfort, however, it is hypothesized that these cases may progress and affect more than ⅔ of the dental width.
Methods
This case series investigated 15 panoramic radiographs of patients who presented with abnormal radiolucent intracoronal zones or PIR lesions within unerupted teeth. Once the affected teeth were confirmed, an observer with 20 years of experience in oral and maxillofacial radiology scored the PIR lesion according to an established classification system.
Results
Twenty cases of PIR lesions were observed amongst the 15 subjects investigated with 75% of cases being located in the maxillary teeth. Lesions mostly presented in molars and premolars (70% of cases). Resorption was detected in the dentin or near the pulp of the tooth in 95% of cases with the most common scoring having resulted in lesions affecting more than ⅔ of the dentine, the enamel and between ⅓-⅔ of dentine as well as dentine and less than ⅓ of the root.
Conclusion
Further understanding of the progression and diagnosis of this defect can assist experts in conceptualizing its aetiology and advice on the most effective treatment plan for patients.
Local Ketorolac Infiltration for Postoperative Pain in Open Trigger Finger Surgery: A Randomized Controlled Trial
Authors: Auwattanamongkol Thanat , Laohaprasitiporn Panai , Monteerarat Yuwarat , Limthongthang Roongsak , Vathana Torpon
Published: July 2024

Background
Multimodal analgesia is crucial for effective postoperative pain management in minor hand surgeries, enhancing patient satisfaction. The use of local wound infiltration with Ketorolac as an adjuvant pain management strategy is proposed for open trigger finger release surgery. This study aims to compare pain scores and functional outcomes between local wound infiltration with Ketorolac and oral non-steroidal anti-inflammatory drugs.
Methods
This study is a double-blind, parallel design, randomized controlled trials. Sixty-nine patients underwent trigger finger surgery between December 2021 and October 2022 were randomized into one of three groups: oral Ibuprofen alone group, local Ketorolac alone group and local Ketorolac with oral Ibuprofen group. The assessment included postoperative numeric rating scale (NRS) pain score, Disabilities of the Arm, Shoulder, and Hand (DASH) score, grip strength, mobility of proximal interphalangeal (PIP) joint. and complications.
Results
NRS pain scores during movement of the operated fingers were significantly lower at 6 hours in local Ketorolac alone group and local Ketorolac with oral Ibuprofen group compared to oral Ibuprofen alone group. However, there were no significant differences between the groups in postoperative DASH scores, grip strength, mobility of PIP joints, and complications.
Conclusions
Local infiltration of Ketorolac is safe for use as an adjuvant postoperative pain management and provides superior pain control during finger movement within the first 6 hours following trigger finger surgery compared to oral NSAIDs.
Clinical trial registration:
Thaiclinicaltrials.org identifier: TCTR20210825002. Registered 25/08/2021. https://www.thaiclinicaltrials.org/show/TCTR20210825002
Trial registration
This clinical trial was registered in the Thai Clinical Trials Registry (TCTR) on 25/08/2021: register number TCTR20210825002. https://www.thaiclinicaltrials.org/show/TCTR20210825002