bluuebunny/crossref_metadata_2025 huggingface dataset:
Identification and Analysis of Micro-Exon Genes in the Rice Genome
Authors: Song Qi , Lv Fang , Tahir ul Qamar Muhammad , Xing Feng , Zhou Run , Li Huan , Chen Ling-Ling
Published: May 2019

Micro-exons are a kind of exons with lengths no more than 51 nucleotides. They are generally ignored in genome annotation due to the short length, whereas recent studies indicate that they have special splicing properties and important functions. Considering that there has been no genome-wide study of micro-exons in plants up to now, we screened and analyzed genes containing micro-exons in two indica rice varieties in this study. According to the annotation of Zhenshan 97 (ZS97) and Minghui 63 (MH63), ~23% of genes possess micro-exons. We then identified micro-exons from RNA-seq data and found that >65% micro-exons had been annotated and most of novel micro-exons were located in gene regions. About 60% micro-exons were constitutively spliced, and the others were alternatively spliced in different tissues. Besides, we observed that approximately 54% of genes harboring micro-exons tended to be ancient genes, and 13% were Oryza genus-specific. Micro-exon genes were highly conserved in Oryza genus with consistent domains. In particular, the predicted protein structures showed that alternative splicing of in-frame micro-exons led to a local structural recombination, which might affect some core structure of domains, and alternative splicing of frame-shifting micro-exons usually resulted in premature termination of translation by introducing a stop codon or missing functional domains. Overall, our study provided the genome-wide distribution, evolutionary conservation, and potential functions of micro-exons in rice.
The “Utility” of Highly Toxic Marine-Sourced Compounds
Authors: Newman David J.
Published: May 2019

Currently a few compounds isolated from marine sources have become drugs, mainly directed towards cancer and pain. Compounds from marine sources have exquisite potencies against eukaryotic cells, as they act as protective agents against attack by predators in the marine environment. Their toxicities act as a “double-edged sword” as they are often too toxic for direct use in humans and thus have to be chemically modified. By linking suitably modified compounds to monoclonal antibodies directed against specific epitopes in mammalian cancer cells, they can be delivered to a specific cell type in humans. This review updates and extends an article published in early 2017, demonstrating how by careful chemical modifications, highly toxic compounds, frequently peptidic in nature, can be utilized as antitumor drug candidates. The antibody-drug- conjugates (ADCs) discussed are those that are currently in clinical trials listed in the NIH Clinical Trials Registry as, “currently active, recruiting or in some cases, recently completed”. There are also some ADCs discussed that are at the advanced preclinical stage, that in some cases, are repurposing current drug entities, and the review finishes with a short discussion of the aplyronines as potential candidate warheads as a result of scalable synthetic processes.
Identification of a Quality Marker of Vinegar-Processed Curcuma Zedoaria on Oxidative Liver Injury
Authors: Cui Herong , Zhang Beibei , Li Guoping , Li Lei , Chen Hongshan , Qi Jinchai , Liu Wenxue , Chen Jing , Wang Penglong , Lei Haimin
Published: May 2019

Curcuma zedoaria (dry stenophora of Curcuma phaeocaulis Val., Curcuma kwangsiensis S. G. Lee et C. F. Liang, or Curcuma wenyujin Y. H. Chen et C.Ling) is a representative herb with clinical effects on liver diseases after being vinegar-processed. The crude Curcuma zedoaria and the processed Curcuma zedoaria (vinegar-boil) have been widely used as mixtures, but their equivalence has not been fully investigated. In this manuscript, quality markers of processed (vinegar-boil) Curcuma zedoaria were investigated by comparison of the compounds and hepatoprotective activities with the crude (three spices) ones. First, GC-MS-based untargeted metabolomics were applied to reveal the discriminatory components and discover potential markers. As a result, a total of six components were identified as potential markers. Then, the hepatoprotective activities were evaluated by dual cell damage models induced by a certain concentration of H2O2 or tertbutyl hydfroperoxide (t-BHP) (55 μM H2O2 or 40 μM t-BHP), which highlighted the potential of the processed Curcuma zedoaria on oxidative stress. Finally, epicurzerenone was identified as its quality marker on oxidative liver injury based on the above results and the cell-based biological assay. Overall, vinegar-processed Curcuma zedoaria was more suitable for the treatment of oxidative liver diseases, and epicurzerenone could be considered as its quality marker.
Sarconesin II, a New Antimicrobial Peptide Isolated from Sarconesiopsis magellanica Excretions and Secretions
Authors: Díaz-Roa Andrea , Espinoza-Culupú Abraham , Torres-García Orlando , Borges Monamaris M. , Avino Ivan N. , Alves Flávio L. , Miranda Antonio , Patarroyo Manuel A. , da Silva Pedro I. , Bello Felio J.
Published: May 2019

Antibiotic resistance is at dangerous levels and increasing worldwide. The search for new antimicrobial drugs to counteract this problem is a priority for health institutions and organizations, both globally and in individual countries. Sarconesiopsis magellanica blowfly larval excretions and secretions (ES) are an important source for isolating antimicrobial peptides (AMPs). This study aims to identify and characterize a new S. magellanica AMP. RP-HPLC was used to fractionate ES, using C18 columns, and their antimicrobial activity was evaluated. The peptide sequence of the fraction collected at 43.7 min was determined by mass spectrometry (MS). Fluorescence and electronic microscopy were used to evaluate the mechanism of action. Toxicity was tested on HeLa cells and human erythrocytes; physicochemical properties were evaluated. The molecule in the ES was characterized as sarconesin II and it showed activity against Gram-negative (Escherichia coli MG1655, Pseudomonas aeruginosa ATCC 27853, P. aeruginosa PA14) and Gram-positive (Staphylococcus aureus ATCC 29213, Micrococcus luteus A270) bacteria. The lowest minimum inhibitory concentration obtained was 1.9 μM for M. luteus A270; the AMP had no toxicity in any cells tested here and its action in bacterial membrane and DNA was confirmed. Sarconesin II was documented as a conserved domain of the ATP synthase protein belonging to the Fli-1 superfamily. The data reported here indicated that peptides could be alternative therapeutic candidates for use in infections against Gram-negative and Gram-positive bacteria and eventually as a new resource of compounds for combating multidrug-resistant bacteria.
The Blossoming of Technology for the Analysis of Complex Aroma Bouquets—A Review on Flavour and Odorant Multidimensional and Comprehensive Gas Chromatography Applications
Authors: Amaral Michelle S.S. , Marriott Philip J.
Published: May 2019

Multidimensional approaches in gas chromatography have been established as potent tools to (almost) attain fully resolved analyses. Flavours and odours are important application fields for these techniques since they include complex matrices, and are of interest for both scientific study and to consumers. This article is a review of the main research studies in the above theme, discussing the achievements and challenges that demonstrate a maturing of analytical separation technology.
Encapsulated Microparticles of (1→6)-β-d-Glucan Containing Extract of Baccharis dracunculifolia: Production and Characterization
Authors: Iurckevicz Genice , Dahmer Débora , Q. Santos Vidiany A. , Vetvicka Vaclav , M. Barbosa-Dekker Aneli , F. H. Dekker Robert , Maneck Malfatti Carlos Ricardo , A. da Cunha Mário A.
Published: June 2019

β-Glucans are biomacromolecules well known, among other biological activities, for their immunomodulatory potential. Similarly, extracts of Baccharis dracunculifolia also possess biological properties and are used in folk medicine for the treatment of inflammation, ulcers, and hepatic diseases. Microparticles containing (1→6)-β-d-glucan (lasiodiplodan) and B. dracunculifolia extract were produced and characterized. A 23 factorial design was employed to define the conditions of production of microparticles by atomization. Lasiodiplodan associated with maltodextrin and gum arabic was studied as a matrix material. Microparticles of 0.4 μm mean size and high phenolics content (3157.9 μg GAE/g) were obtained under the optimized conditions. The microparticle size ranged from 0.23 to 1.21 µm, and the mathematical model that best represented the release kinetics of the extract was the Korsmeyer-Peppas model. Diffusional exponent (n) values of 0.64 at pH 7.7 and 1.15 at pH 2.61 were found, indicating particles with a non-Fickian or anomalous transport system, and Super Case II transport, respectively. Thermal analysis indicated that the microparticles demonstrated high thermal stability. The X-ray diffraction analyses revealed an amorphous structure, and HPLC-DAD analysis showed microparticles rich in phenolic compounds: caffeic acid, p-coumaric acid, and catechin. The microparticles obtained comprise a new biomaterial with biological potential for applications in different fields.
Alcohol Abstinence Prediction on the Basis of Conservation of Resources Theory by Stevan E. Hobfoll a Study of Polish Alcohol-Dependent Persons in the Early Phase of Recovery
Authors: Modrzyński Robert
Published: June 2019

Striving for permanent alcohol abstinence can be difficult to achieve or even impossible, which in turn often results in discontinuation of treatment. The main area of interest among researchers dealing with the problem of alcohol dependence is the ability to maintain abstinence. Despite numerous studies in this area, there is still no unambiguous data on the factors affecting the recovery process of alcohol-dependent persons. The main goal of this publication is to present the Conservation of Resources Theory (COR) by S. Hobfoll as an alternative concept to understanding alcohol dependence and to answer whether maintaining abstinence can be predicted, and what kind of resources play a key role in alcohol dependence recovery. A series of two comparisons of independent variables (level, gain and loss of resources) were made in the first and sixth month after the beginning of therapy. Questionnaire longitudinal studies of 350 alcohol-dependent persons were used. Research results show that distribution of resources is of great significance in maintaining abstinence. It is important for the alcohol-dependent person’s recovery process to have the opportunity to gain resources. Experiencing loss of resources in the beginning of treatment often determines their return to drinking. The project provides empirical support for research on the role of supportive factors in an alcohol-dependent person’s recovery process.
An Analytical Geometry Optimization Model for Current-Mode Cross-Like Hall Plates
Authors: Xu Yue , Hu Xingxing , Jiang Lei
Published: May 2019

This paper presents a new analytical geometry optimization model to depict the optimal current sensitivity and signal-to-noise ratio (SNR) for the current-mode Hall devices. The conformal mapping calculation is performed to study the influence of device geometry on the current sensitivity and SNR of the current-mode cross-like Hall plates. The analytical model indicates that a current-mode cross-like Hall plate can achieve optimal current sensitivity and SNR in the device length-to-width ratio (L/W) range of 0.4–0.5 when the thermal noise is taken into account. Three-dimensional (3D) technology computer aided design (TCAD) simulation validates the accuracy of the analytical model. The proposed analytical model provides a geometry design rule to achieve optimal sensitivity and SNR at the same time for the current-mode cross-like Hall plates.
Perfusion Microfermentor Integrated into a Fiber Optic Quasi-Elastic Light Scattering Sensor for Fast Screening of Microbial Growth Parameters
Authors: Soares Marco César Prado , Vit Franciele Flores , Suzuki Carlos Kenichi , de la Torre Lucimara Gaziola , Fujiwara Eric
Published: May 2019

This research presents a microfermentor integrated into an optical fiber sensor based on quasi-elastic light scattering (QELS) to monitor and swiftly identify cellular growth kinetic parameters. The system uses a 1310 nm laser light that is guided through single-mode silica optical fibers to the interior of perfusion chambers, which are separated by polycarbonate membranes (470 nm pores) from microchannels, where a culture medium flows in a constant concentration. The system contains four layers, a superior and an inferior layer made of glass, and two intermediate poly(dimethylsiloxane) layers that contain the microchannels and the perfusion chambers, forming a reversible microfluidic device that requires only the sealing of the fibers to the inferior glass cover. The QELS autocorrelation decay rates of the optical signals were correlated to the cells counting in a microscope, and the application of this microsystem to the monitoring of alcoholic fermentation of Saccharomyces cerevisiae resulted in the kinetic parameters of KM = 4.1 g/L and μm = 0.49 h−1. These results agree with both the data reported in the literature and with the control batch test, showing that it is a reliable and efficient biological monitoring system.
Assessment of BeiDou-3 and Multi-GNSS Precise Point Positioning Performance
Authors: Jiao Guoqiang , Song Shuli , Ge Yulong , Su Ke , Liu Yangyang
Published: May 2019

With the launch of BDS-3 and Galileo new satellites, the BeiDou navigation satellite system (BDS) has developed from the regional to global system, and the Galileo constellation will consist of 26 satellites in space. Thus, BDS, GPS, GLONASS, and Galileo all have the capability of global positioning services. It is meaningful to evaluate the ability of global precise point positioning (PPP) of the GPS, BDS, GLONASS, and Galileo. This paper mainly contributes to the assessment of BDS-2, BDS-2/BDS-3, GPS, GLONASS, and Galileo PPP with the observations that were provided by the international Global Navigation Satellite System (GNSS) Monitoring and Assessment System (iGMAS). The Position Dilution of Precision (PDOP) value was utilized to research the global coverage of GPS, BDS-2, BDS-2/BDS-3, GLONASS, and Galileo. In particular, GPS-only, BDS-2-only, BDS-2/BDS-3, GLONASS-only, Galileo-only, and multi-GNSS combined PPP solutions were analyzed to verify the capacity of the PPP performances in terms of positioning accuracy, convergence time, and zenith troposphere delay (ZTD) accuracy. In view of PDOP, the current BDS and Galileo are capable of global coverage. The BDS-2/BDS-3 and Galileo PDOP values are fairly evenly distributed around the world similar to GPS and GLONASS. The root mean square (RMS) of positioning errors for static BDS-2/BDS-3 PPP and Galileo-only PPP are 10.7, 19.5, 20.4 mm, and 6.9, 18.6, 19.6 mm, respectively, in the geographic area of the selected station, which is the same level as GPS and GLONASS. It is worth mentioning that, by adding BDS-3 observations, the positioning accuracy of static BDS PPP is improved by 17.05%, 24.42%, and 35.65%, and the convergence time is reduced by 27.15%, 27.87%, and 35.76% in three coordinate components, respectively. Similar to the static positioning, GPS, BDS-2/BDS-3, GLONASS, and Galileo have the basically same kinematic positioning accuracy. Multi-GNSS PPP significantly improves the positioning performances in both static and kinematic positioning. In terms of ZTD accuracy, the difference between GPS, BDS-2/BDS-3, GLONASS, and Galileo is less than 1 mm, and the BDS-2/BDS-3 improves ZTD accuracy by 20.48% over the BDS-2. The assessment of GPS, BDS-2, BDS-2/BDS-3, GLONASS, Galileo, and multi-GNSS global PPP performance are shown to make comments for the development of multi-GNSS integration, global precise positioning, and the construction of iGMAS.
INARMA Modeling of Count Time Series
Authors: Weiß Christian H. , Feld Martin H.-J. M. , Mamode Khan Naushad , Sunecher Yuvraj
Published: June 2019

While most of the literature about INARMA models (integer-valued autoregressive moving-average) concentrates on the purely autoregressive INAR models, we consider INARMA models that also include a moving-average part. We study moment properties and show how to efficiently implement maximum likelihood estimation. We analyze the estimation performance and consider the topic of model selection. We also analyze the consequences of choosing an inadequate model for the given count process. Two real-data examples are presented for illustration.
Exact Solutions to Time-Fractional Fifth Order KdV Equation by Trial Equation Method Based on Symmetry
Authors: Liu Tao
Published: June 2019

We study a fifth order time-fractional KdV equation (FKdV) under meaning of the conformal fractional derivative. By trial equation method based on symmetry, we construct the abundant exact traveling wave solutions to the FKdV equation. These solutions show rich evolution patterns including solitons, rational singular solutions, periodic and double periodic solutions and so forth. In particular, under the concrete parameters, we give the representations of all these solutions.
Genistein Has Antiviral Activity against Herpes B Virus and Acts Synergistically with Antiviral Treatments to Reduce Effective Dose
Authors: LeCher Julia C. , Diep Nga , Krug Peter W. , Hilliard Julia K.
Published: May 2019

Herpes B virus is a deadly zoonotic agent that can be transmitted to humans from the macaque monkey, an animal widely used in biomedical research. Currently, there is no cure for human B virus infection and treatments require a life-long daily regimen of antivirals, namely acyclovir and ganciclovir. Long-term antiviral treatments have been associated with significant debilitating side effects, thus, there is an ongoing search for alternative efficacious antiviral treatment. In this study, the antiviral activity of genistein was quantified against B virus in a primary cell culture model system. Genistein prevented plaque formation of B virus and reduced virus production with an IC50 value of 33 and 46 μM for human and macaque fibroblasts, respectively. Genistein did not interfere directly with viral entry, but instead targeted an event post-viral replication. Finally, we showed that genistein could be used at its IC50 concentration in conjunction with both acyclovir and ganciclovir to reduce their effective dose against B virus with a 93% and 99% reduction in IC50 values, respectively. The results presented here illuminate the therapeutic potential of genistein as an effective antiviral agent against B virus when used alone or in combination with current antiviral therapies.
Emotions vocabulary and the reconceptualisation of emotions in Ann Radcliffe’s “The Italian, or the Confessional of the Black Penitents”
Authors: Andonova-Kalapsazova Elena
Published: June 2019

The article undertakes the analysis of Ann Radcliffe’s novel The Italian, or the Confessional of the Black Penitents (1797) from a history of literary emotions perspective which, I argue, yields insights into the attitudes towards emotions embedded in Radcliffe’s works. A reading of the novel from such a perspective also complements the critical studies of the artist’s engaging with the eighteenth-century cult of sensibility. The novel is read as a text that registered but also participated in the dissemination of an epistemology of emotional experience articulated in the idiom of eighteenth-century moral philosophers – Francis Hutcheson, David Hume and Adam Smith - at the same time as it retained some of the older, theology-based conceptions of passions and affections. The dynamic in which the two frameworks for understanding the emotions exist in the novel is explored through a close reading of the vocabulary in which Radcliffe rendered the emotional experiences of her fictional characters. In this reading it is the passions which are found to have been invested with a variety of meanings and attributed a range of moral valences that most noticeably foreground the movement from a generally negative towards a more complex appreciation of powerful emotions.
Un chantier royal : Saint-Pierre de Montmartre (1131-1134). Louis VI le Gros et l’invention du gothique
Authors: Plagnieux Philippe
Published: June 2019

The king’s works : Saint-Pierre de Montmartre (1131-1134). Louis VI le Gros and the invention of gothic

The abbey of Saint-Pierre de Montmartre, the only religious foundation directly resulting from the royal patronage of Louis VI, is also one of the monuments that expressed the early gothic style of architecture. Our knowledge of the edifice, however, is based on an article by F. Deshoulières, published in 1913. Louis VI and his wife Adélaïde de Savoie are thought to have launched the project in 1133, but the work was thought to have progressed slowly with a change of plan. On the contrary, by returning to the texts, to critical observation and an analysis of the architectural conception, one can show that the abbey, financed by the royal couple and envisaged as a Capetian memorial monument, was built in a single campaign between 1131 and 1134. The original central vessel had rib vaulting, but without any system for containing the strong pressure on the empty spaces allied with this kind of vaulting. The result was that thirty or forty years after the church was built, the ribs began to show signs of weakness, which required their dismounting and replacement by a wooden covering.
Le Perche : un espace de transition
Authors: Pelatan Jean
Published: June 2019

Type de «pays » d'origine physique (Pertica silva, ancienne zone forestière), le Perche demeure un espace composite, avec une agriculture en situation inconfortable, aux exploitations souvent un peu trop vastes pour pratiquer l'intensification bovine des bocages plus occidentaux, mais trop petites pour suivre l'exemple céréalier beauceron. C'est également un espace social où la population reste réticente vis-à-vis des changements tout en ayant su faire face à des difficultés graves comme le déclin de l'élevage du cheval, et prendre des initiatives en matière de créations d'entreprises. Espace ambigu .enfin, où l'identité est moins affirmée actuellement que lors de la grande époque du cheval, partie des marges de la France de l'Ouest, le Perche reste une juxta¬ position de «pays » avec ses périphéries autour d'un noyau central : le vrai Perche, proche à tous égards de la Normandie, entre Mortagne et Nogent-le-Rotrou.
J.-P. Sartre et Le Havre
Authors: Jeanne Gilbert
Published: June 2019

Les hasards d'une nomination, acceptée essentiellement pour des raisons économiques, font que J.-P. Sartre vient au Havre (qu'il dénommera Bouville), comme professeur de philosophie, en février 1931.

De la rencontre avec la ville et ses habitants naîtra un roman qui fera entrer dans notre musée culturel la notion neuve de «nausée ».

Cette vision du monde, si éloignée de nos habitudes ordinaires, l'écrivain parvient à la faire accepter, en recourant à des procédés littéraires, basés tout particulièrement sur l'utilisation d'un amalgame parachronique de «petits faits vrais» qui sont puisés dans une documentation considérable et représentent autant de clins d'œil complices adressés au lecteur normand averti.
De l'enfouissement des livres
Authors: Gleize Joëlle
Published: June 2019

We plan to study the way in which books, at first omnipresent in the earlier versions of Madame Bovary, tend to disappear in later ones. Their deletion, in the process of writing, stems from the realisation that their presence in the text prevents its ultimate transparency, its "realism".
QUALITY OF LIFE IN PATIENTS WITH CHRONIC VENOUS DISEASES AND METHODS OF ITS IMPROVEMENT (review)
Authors: Pytetska N.
Published: June 2019

QUALITY OF LIFE IN PATIENTS WITH CHRONIC VENOUS DISEASES AND METHODS OF ITS IMPROVEMENT (review)N.I. Pytetska Assessment of the quality of life is one of the leading directions in modern medicine and continues to develop intensively, remaining an integral part of comprehensive analysis of new methods of diagnosis, treatment and prevention. This article provides information about the history of the concept "quality of life" and the ambiguity of terminology. Particular attention is paid to the necessity of studying this indicator in patients with chronic veins diseases, the relevance of this direction in the early stages of the disease, as well as medicines able to solve the main tasks of drug therapy, to restore work capacity and, as a result improve the patient's life quality.Key words: quality of life, chronic venous diseases, diosmin. ЯКІСТЬ ЖИТТЯ ХВОРИХ НА ХРОНІЧНІ ЗАХВОРЮВАННЯ ВЕН ТА МЕТОДИ ЇЇ ПОКРАЩЕННЯ (огляд)Питецька Н.І.Вивчення якості життя є одним із провідних напрямків сучасної медицини й продовжує інтенсивно розвиватись, залишаючись невід'ємною частиною всебічного аналізу нових методів діагностики, лікування і профілактики. У даній статті представлено інформацію про історію виникнення поняття «якість життя», неоднозначність термінології. Особливуувагу приділено необхідності оцінки даного показника у хворих на хронічні захворювання вен, актуальності цього напрямку на ранніх стадіях захворювання, а також  лікарським засобам, які здатні вирішувати основні завдання медикаментозної терапії, відновлювати працездатність і підвищувати якість життя пацієнта.Ключові слова: якість життя, хронічні захворювання вен, діосмін. КАЧЕСТВО ЖИЗНИ БОЛЬНЫХ С ХРОНИЧЕСКИМИ ЗАБОЛЕВАНИЯМИ ВЕН И МЕТОДЫ ЕГО УЛУЧШЕНИЯ (обзор)Питецкая Н.И.Изучение качества жизни является одним из ведущих направлений современной медицины и продолжает интенсивно развиваться, оставаясь неотъемлемой частью всестороннего анализа новых методов диагностики, лечения и профилактики. В данной статье представлена информация об истории возникновения понятия «качество жизни», неоднозначности терминологии. Особое внимание уделено необходимости оценки данного показателя у больных хроническими заболеванияи вен, актуальности этого направления на ранних стадиях заболевания, а также  лекарственным препаратам, которые способны решать основные задачи медикаментозной терапии, восстанавливать трудоспособность и повышать качество жизни пациента.Ключевые слова: качество жизни, хронические заболевания вен, диосмин.
THE RELATIONS BETWEEN PROINFLAMMATORY AND ATHEROGENIC MARKERS AND VESSELS REMODELING IN PATIENTS WITH HYPERTENSIVE DISEASE
Authors: Kysylenko K.
Published: June 2019

RELATIONSHIP BETWEEN PROINFLAMMATORY AND ATHEROGENIC MARKERS AND VESSELS REMODELING IN PATIENTS WITH HYPERTENSIVE DISEASEKysylenko K., Kovalyova O. Resume. The article presents clinical data that shows the relationship between proinflammatory markers (IL-22) and atherogenic markers (indices of lipid spectrum) in the formation of structural and functional changes in the carotid arteries, which can be considered as early subclinical markers of atherosclerotic vascular damage in the cohort of patients with comorbidity of hypertension and obesity. Such a combined pathology can be considered a trigger of metabolic events adversely affecting the lipid profile and directing these patients to a high cardiometabolic risk group.Key words: atherogenesis, hypertension, interleukin-22, lipid profile, proinflammatory status, remodeling of carotid arteries.Резюме ЗВ’ЯЗОК ПРОЗАПАЛЬНИХ ТА АТЕРОГЕННИХ МАРКЕРІВ З РЕМОДЕЛЮВАННЯМ СУДИН У ПАЦІЄНТІВ З ГІПЕРТОНІЧНОЮ ХВОРОБОЮКисиленко К., Ковальова О.В статті наведені клінічні данні, які відображають зв'язок прозапальних маркерів (ІЛ-22) та атерогенних маркерів (показників ліпідного спектру) у формуванні структурно-фунціональних змін сонних артерій, які можна розглядати ранніми субклінічними маркерами атеросклеротичного ураження судин у когорти хворих при коморбідності ГХ та ожиріння. Таку поєднану патологію можна розглядати тригерним механізмом запуску несприятливих метаболічних подій, які негативно впливають на ліпідний профіль та спрямовують цих пацієнтів до зони високого кардіометаболічного ризику.Ключові слова: атерогенез, гіпертонічна хвороба, інтерелейкін-22, ліпідний профіль, прозапальний статус, ремоделювання сонних артерій.Резюме.СВЯЗЬ ПРОВОСПАЛИТЕЛЬНЫХ И АТЕРОГЕННЫХ МАРКЕРОВ С РЕМОДЕЛИРОВАНИЕМ СОСУДОВ У ПАЦИЕНТОВ С ГИПЕРТОНГИЧЕСКОЙ БОЛЕЗНЬЮКисиленко Е., Ковалёва О.В статье приведены клинические данные, которые отображают связь провоспалительных маркеров (ИЛ-22) и атерогенных маркеров (показателей липидного профиля) в формировании структурно-функциональных изменений сонных артерий, которые можно расценивать как ранние субклинические маркеры атеросклеротического поражения сосудов у когорты больных при коморбидности гипертонической болезни и ожирения. Такую сочетанную патологию можно рассматривать триггерным механизмом запуска неблагоприятных метаболических событий, которые негативно влияют на липидный профиль и направляют этих пациентов в зону высокого кардиометаболического риска.Ключевые слова: атерогенез, гипертоническая болезнь, интерлейкин-22, липидный профиль, провоспалительный профиль, ремоделирование сонных артерий.
IRON SUPPLEMENTATION IN TREATMENT OF CHILDREN WITH LOW RESPIRATORY INFECTION AND IRON DEFICIENCY ANEMIA
Authors: Gonchar M. , Ishenko T. , Tyshko A. , Orlova N. , Saenko V. , Bodnar O.
Published: June 2019

Gonchar M., Ischenko T., Tyshko A., Orlova N., Saenko V., Bondar O.Upper respiratory tract infections as well as bronchitis and pneumonia are most common causes for hospitalization of children. Younger children are more predisposed to these problems and its complications. Anemia is one of the most common comorbidity of this pathology. We analyzed 52 case histories of children diagnosed with pneumonia and deficiency anemia. The study evaluated presentation, history, clinical and laboratory data. Our results suggest that ferrotherapy helps with acceleration of low respiratory tract infections’ symptomsKey words: low respiratory tract infection, anemia, children, iron supplement РезюмеРоль ферротерапії в лікуванні дітей із інфекціями нижніх дихальних шляхів та залізодефіцитною анемієюГончарь М., Іщенко Т., Тишко А., Орлова Н., Саєнко В., Бондарь О. Інфекція верхніх дихальних шляхів, а також бронхіти та пневмонії є найбільш частим чинником лікування дітей в лікарняних установах. Чим молодша дитина, тим частіше ці захворювання виникають, і тим важче ускладнення. Анемія є одним з найбільш розповсюджених станів, що співіснують із даною патологією. Нами було проаналізовано 52 історії хвороби дітей з діагнозом пневмонія і дефіцитна анемія. Дослідження оцінювало скарги, дані анамнезу та результати клініко-лабораторних обстежень. Отримані дані свідчать про те, що проведеня ферротерапії сприяє редукції симптомів інфекції нижніх дихатльних шляхів у дітей.Ключові слова: інфекція нижніх дихальних шляхів, анемія, діти, ферротерапия РезюмеРоль ферротерапии в лечении детей с инфекциями нижних  дыхательных путей и железодефицитной анемией Гончарь М., Ищенко Т., Тышко А., Орлова Н., Саенко В., Бондарь О.Инфекции верхних дыхательных путей, а также бронхиты и пневмонии является наиболее частой причиной лечения детей в больничных учреждениях. Чем младше ребенок, тем чаще эти заболевания возникают, и тем тяжелее осложнения. Анемия является одним из самых распространенных состояний, сопутствующих данной патологии. Нами было проанализировано 52 истории болезни детей с диагнозом пневмония и дефицитная анемия. Исследование включало анализ жалоб, анамнеза, клинико-лабораторных данных. Полученные данные свидетельствуют в пользу того, что проведение ферротерапии способствует ускорению редукции симптомов инфекции нижних дыхательных путей у детей.Ключевые слова: инфекция нижних дыхательных путей, анемия, дети, ферротерапия.
A avaliação da aprendizagem na educação pré-escolar. O portefólio da criança
Authors: Jesus G. Marchão Amélia de , Presumido Fitas Ana Cristina
Published: May 2019

Este estudo leva-nos a reconhecer a importância da avaliação no contexto da educação pré-escolar e a encará-la num sentido contextual e sistémico. Quando se considera a criança como um ‘ser competente’, torna-se necessário aceitar a sua participação e capacidade de decidir, nomeadamente quando se trata de avaliar o seu percurso e as suas aprendizagens. Nesse sentido, o/ educador/a de infância deve promover práticas alternativas de avaliação das aprendizagens das crianças, surgindo o portefólio como um instrumento que promove a comunicação, a curiosidade, a partilha e a utilização do pensamento para atribuir significados. O portefólio apresenta-se como um instrumento de avaliação inovador e a sua construção é amplamente participada e valorizada pelas crianças e também pelas famílias, assumindo o educador um papel de orientador do processo construtivo e formativo em que a criança é a protagonista.
Programación de la enseñanza en la escuela primaria. ¿Qué se enseña de Física?
Authors: Cordero Silvina , Montenegro Jesica , Traverso Viviana
Published: May 2019

El presente trabajo apunta a describir las prácticas de programación de la enseñanza, específicamente en lo referido a la planificación, de tres docentes de escuela primaria de la Provincia de Buenos Aires (Argentina) en el área curricular de Ciencias Naturales. Se propone caracterizar los contenidos de Física que las docentes seleccionan, organizan y secuencian para su enseñanza, a partir del análisis de documentos escritos entregados por ellas mismas. Se trata de un trabajo descriptivo y el enfoque adoptado integra rasgos de los estudios de corte interpretativo.

El análisis documental realizado posibilitó describir los formatos de las planificaciones y componentes, identificar algunas configuraciones y modalidades de programación y los saberes implicados en su producción. En lo referido a la selección de contenidos físicos se identificaron diferentes grados de apropiación y resignificación del texto curricular y diversas mediaciones. De los documentos analizados se infirieron algunos de los conocimientos pedagógicos del contenido del área por parte de las docentes y su actuación como intérpretes de las prescripciones curriculares. Al mismo tiempo, se concluyeron funciones otorgadas a la planificación y el enfoque de enseñanza de las ciencias naturales que sustenta su práctica.
O uso das tecnologias no trabalho pedagógico
Authors: Pedreira Ana Júlia , Nagumo Estevon , Lisboa da Silva Alessandra , Siqueira Cerqueira Teresa Cristina
Published: May 2019

Este artigo apresenta resultados de uma pesquisa sobre o uso das tecnologias da informação e da comunicação (TIC) no trabalho pedagógico cujos objetivos foram: verificar quais são as tecnologias utilizadas pelos professores em seu planejamento e em sala de aula; mapear como o professor faz uso da tecnologia em seu trabalho pedagógico e investigar a opinião deste sobre o impacto da tecnologia para o interesse do aluno. Foram obtidos 88 respostas por meio de um questionário online de professores em exercício na Educação Básica ou Superior. As análises dos dados com abordagem qualitativa e de análise de conteúdo apontaram que, em geral, há um uso da tecnologia em sala de aula de maneira ilustrativa, sendo pouco utilizada de forma interativa e criativa, pelos professores participantes. Os professores participantes da pesquisa reconhecem que as novas tecnologias atraem a atenção dos alunos, seja por sua familiaridade ou por seu formato multimídia. Eles ressaltam a necessidade de clareza nos objetivos pedagógicos e adequação do conteúdo à melhor forma de apresentação, levando em consideração as possibilidades das TICs em sala de aula.
El rol de las comunidades de aprendizaje en la construcción de una visión común para la enseñanza de computación en las escuelas
Authors: Martínez M. Cecilia , Echeveste M. Emilia
Published: May 2019

Introducir innovaciones en la escuela requiere desarrollar en la comunidad educativa una visión común sobre los contenidos a enseñar, las estrategias de enseñanza y las implicancias educativas, subjetivas y sociales de la innovación. Este trabajo documenta una experiencia de formación docente centrada en construir una visión común sobre la enseñanza de la programación en computación en la escuela secundaria, siguiendo el modelo de comunidades de aprendizaje. Durante la experiencia se analizaron 26 encuestas a docentes, las cuales mostraron un cambio en las creencias acerca del enfoque de la enseñanza de la computación en las escuelas. Documentamos las estrategias de formación docente que contribuyeron a construir una visión común y el rol de las comunidades de aprendizaje en la construcción de esta visión.
O uso das TICs na formação continuada: iniciativas e experiências presentes na produção acadêmica brasileira
Authors: Oliveira Nunes Marcela de , De Fátima Guerino Mariana , Lorena Stanzani Enio de
Published: May 2019

O presente trabalho versa sobre a produção bibliográfica acerca do tema Tecnologia da Informação e Comunicação (tic) e Formação Continuada, presente em onze periódicos nacionais da área da Educação. Conscientes dos esforços do Estado para inserir as chamadas tics na realidade escolar, por meio de programas e políticas educacionais, essa pesquisa busca avaliar a produção acadêmica sobre o assunto, na tentativa de refletir como essa temática está sendo debatida no interior das universidades e dos grupos de pesquisa. Selecionaram-se onze publicações vinculadas a distintas universidades no período de 1991 a 2013, a fim de reunir artigos que apresentassem experiências e iniciativas que coadunassem a formação continuada de professores com o uso de tecnologias direcionadas às práticas de ensino e aprendizagem. Observamos que parte do corpus analisado incide na teorização do uso das tecnologias sem interface com o cotidiano escolar, sendo assim, constata-se a carência de estudos e investigações acerca do uso das tics na formação continuada.
A Língua Espanhola com letras maiúsculas: uma questão de política linguística
Authors: Jacumasso Tadinei Daniel
Published: May 2019

O objetivo deste artigo é discutir questões relacionadas às políticas linguísticas, mais especificamente no que concerne à Lei 11.161/2005, que prevê a oferta obrigatória da disciplina de Língua Espanhola nas escolas brasileiras. A pesquisa justifica-se por lançar um olhar sobre uma temática que tem ocupado, nos últimos anos, parte das discussões políticas e educacionais no Brasil. Além disso, por acompanhar como (não) tem sido cumprida a mencionada Lei do Espanhol. O trabalho analisa dados retirados de um órgão oficial da Secretaria de Estado da Educação do Paraná, Brasil, fazendo um comparativo entre os anos de 2010 e 2012.
Promoción de la salud en entornos educativos. El empleo de NTIC en el aprendizaje en salud
Authors: Lellis Martín de , Calzetta Cecilia , Gómez Tamara
Published: May 2019

Tras una breve referencia al problema de la exclusión juvenil del sistema educativo, se exponen en este artículo los lineamientos generales de un proyecto integral orientado a promover entornos educativos y comportamientos favorables para la salud, que se lleva a cabo desde el ámbito de extensión universitaria y con acuerdo institucional para su implementación en dos escuelas de nivel medio emplazadas en la región metropolitana contigua a la Ciudad Autónoma de Buenos Aires. En dicho proyecto se desarrolla específicamente el empleo de nuevas tecnologías de comunicación e información (ntic), orientado a promover conocimientos y hábitos de promoción de la salud, informándose los siguientes resultados: a) mayor integración e interés de los jóvenes hacia las tareas curriculares y extracurriculares relativas a la promoción de la salud; b) generación y sostenimiento de redes sociales que otorgan pertenencia y refuerzan el vínculo con la institución; c) incremento de habilidades relacionadas con el uso de la información a través de tecnologías altamente demandadas en el mundo laboral; d) empleo responsable de la tecnología mediante reglas consensuadas de uso, y e) mitigación del impacto de la brecha tecnológica y su relación con la calidad educativa, al facilitar el acceso más universal a las nuevas tecnologías de información y comunicación. Finalmente, se formulan reflexiones en torno al carácter innovador de la experiencia y a la sustentabilidad que adquiere el empleo de materiales educativos apoyados en las nuevas tecnologías de comunicación e información en las instituciones educativas mediante actividades orientadas a promover la participación y el aprendizaje juvenil en temáticas prioritarias de salud.
Una aproximación a la construcción colaborativa de aprendizaje mediante la realización de una actividad práctica en Biología con Google Docs
Authors: Sanz Gil José Javier
Published: May 2019

En el presente artículo se presentan los hallazgos y percepciones que presentan los estudiantes en relación al uso de la herramienta colaborativa de Google Docs respecto a la realización de una experiencia práctica de Biología del curso de 1º de Bachillerato y en general de las tareas académicas en la realización de esta. Al mismo tiempo se explora si el aprendizaje y comprensión de los criterios para la elaboración y realización de dicha práctica pueden ser favorecidos mediante la utilización de esta herramienta colaborativa. Al analizar los datos obtenidos estos señalan que la mayoría de los estudiantes encuestados perciben de manera positiva la utilización de la herramienta colaborativa de Google Docs al señalar que ésta favorece la construcción de trabajos prácticos en un ambiente virtual facilitando la interacción y colaboración entre el grupo de participantes. Por otra parte, los resultados también señalan que la comprensión de la metodología en la realización de las actividades prácticas en el área de Biología mejoran notablemente con la utilización de esta herramienta colaborativa.
Formación para la innovación en educación media superior. Una experiencia formativa de directores escolares en México
Authors: Morales López Graciela
Published: May 2019

La formación de directivos escolares constituye un gran reto para los diferentes sistemas educativos, particularmente cuando el nivel atraviesa por una reforma, como es el caso del nivel medio superior en México. Por ello, fortalecer la formación continua de los directores se constituye en un reto y una obligación para el sistema y para formadores e instituciones formadoras de docentes. La reforma en educación media superior en México demanda que los directores adquieran un perfil basado en competencias que los vuelva altamente capaces de liderar procesos de cambio y de innovar en la escuela. Por este motivo, recientemente se implementó y evaluó un programa de formación para directivos escolares que tuvo dos rasgos distintivos: por un lado, fue el primer esfuerzo formativo integrador de subsistemas de educación pública en el norteño estado de Nuevo León; y por otro lado, brindó la oportunidad a los directores de conocer, comparar y abrirse al cambio y a la innovación, al participar de un intercambio para interactuar con colegas del nivel en la ciudad de Nueva York, lo que les llevó a conocer y valorar otras prácticas. Dicha experiencia fue el Diplomado Ejecutivo en Liderazgo y Dirección de Instituciones de Educación Media Superior, implementado en 2014 con la participación de 76 directivos.
Ciencia de la Sostenibilidad: ¿Una nueva disciplina o un nuevo enfoque para todas las disciplinas?
Authors: Vilches Amparo , Gil Pérez Daniel
Published: May 2019

Al inicio de este siglo XXI comenzó a desarrollarse un nuevo dominio científico, la Ciencia de la Sostenibilidad, con el objetivo explícito de hacer frente a la actual situación de emergencia planetaria e impulsar la transición a sociedades sostenibles. Una nueva forma de hacer ciencia para un nuevo período de la historia de la humanidad, el Antropoceno, en el que el planeta está experimentando grandes cambios, debidos principalmente a la acción de los seres humanos, que amenazan la supervivencia de la propia especie humana. Nuestro propósito en este trabajo ha sido analizar en qué medida esta Ciencia de la Sostenibilidad puede realmente contribuir a la necesaria transición a la Sostenibilidad. Con ese objeto hemos estudiado su desarrollo desde sus orígenes hasta la actualidad. Por otra parte hemos estudiado si las características de la Ciencia de la Sostenibilidad suponen una mejora real respecto a las contribuciones que numerosas disciplinas (desde la Educación Ambiental a la Química Verde o la Economía baja en carbono) venían haciendo a la resolución de problemas socioambientales. Los resultados de estos análisis permiten, en primer lugar, reconocer un planteamiento radicalmente novedoso, con las características de una auténtica revolución científica, susceptible de contribuir muy significativamente a la transición a la Sostenibilidad. En segundo lugar, los criterios cuantitativos manejados llevan a constatar el extraordinario vigor de la nueva disciplina.
La experiencia de lxs estudiantes del Instituto Superior de Educación Física “Ciudad de General Pico”. Relaciones entre la cultura experiencial y la formación inicial
Authors: Acosta Fernando , Pizarro Daniela de los Ángeles , Suárez Vranken César
Published: May 2019

Este trabajo es un avance de investigación. El objetivo fue analizar, en el espacio de la formación docente inicial, la relación entre la cultura experiencia de lxs estudiantes ingresantes en el desarrollo de la carrera. La metodología utilizada es de carácter cualitativa. Como instrumentos de recolección de la información apelamos al análisis de documentos y entrevista como estrategia metodológica. Acercarnos a la problemática nos deja los siguientes resultados. Advertimos un discurso que tiene un alto consenso entre lxs estudiantes que gira en torno a la reproducción del proyecto formativo. Aparece tibiamente la cuestión del poder, es decir, el lugar de lo institucional en la conformación de los discursos. Por otra parte, el deporte es problematizado desde la perspectiva escolar tomando como referencia la inclusión o exclusión y los programas de competencias deportivas locales, regionales y nacionales. La educación física (EF de aquí en adelante) del hacer es interesantemente interpelada desde el lugar que la escuela le asigna al área disciplinar, la evaluación y el abandono de la función de enseñanza (“tirar la pelota”)
Trabalho colaborativo docente e educação plurilingue: que subversões a uma gramática da escola?
Authors: Mesquita Luciana , Pinho Ana Sofia , Andrade Ana Isabel
Published: May 2019

Assumindo-se que uma educação em línguas guiada pelos princípios do plurilinguismo se rege sob um signo de diluição de fronteiras linguísticas e disciplinares, torna-se necessário um maior diálogo entre as línguas do currículo escolar e a um trabalho mais coordenado entre os professores. Essas demandas carecem, contudo, de serem analisadas em função de um conjunto de regras e estruturas sedimentadas que caracterizam a escola e que oferecem resistências a iniciativas de mudança educativa.Considerando esse enquadramento, este estudo assume como ponto de partida as seguintes questões: a) que conceções de colaboração docente surgem associadas às dinâmicas de trabalho que têm lugar em departamentos de línguas nas escolas? E, dentro desse quadro, b) que dinâmicas de interação didática entre as línguas podem ser consideradas transformadoras?
Niños de preescolar participando en la investigación educativa mediante el enfoque mosaico
Authors: Fritz Macías Heidi
Published: May 2019

En años recientes, diversos organismos internacionales han reconocido la importancia de apoyar el desarrollo de la infancia de manera integral, y la investigación educativa no ha sido ajena a esta tendencia. Sin embargo, hasta este momento se ha enfocado casi exclusivamente a conocer la perspectiva del adulto acerca de la infancia, y la voz de los niños ha quedado prácticamente excluida. Los niños son los expertos en sus vidas y son los principales conocedores de sus intereses y necesidades al constituirse en los auténticos protagonistas de su existencia. De acuerdo con el concepto de niño activo, que construye socialmente sus interacciones con sus pares y los adultos con los que convive, se puede ampliar el conocimiento que se tiene de la infancia en sus procesos de socialización y aprendizaje. Este trabajo muestra que el enfoque mosaico es una forma productiva de conocer e incluir la perspectiva de los niños en los procesos de investigación respecto a los ambientes escolares en los que participan y un estímulo para imaginar formas creativas de llegar a sus experiencias vitales.