bluuebunny/crossref_metadata_2025 huggingface dataset:
THE INFLUENCE OF SERVANT LEADERSHIP ON FOLLOWERS’ CREATIVITY WITH CLIMATE FOR CREATIVITY AS MEDIATION
Authors: Atmoko Tsamarah Dzubyanni , Tjahjono Heru Kurnianto
Published: December 2024

Introduction: As a developing nation, Indonesia persists in its endeavors to boost national growth, including initiatives to support the creative industry through startup companies. This research aims to examine the impact of servant leadership on followers’ creativity, with climate for creativity as the mediating factor.
Methods: This research is a quantitative study using primary data obtained through a questionnaire survey from 178 employees working in 73 Indonesian startup companies. The sampling method was purposive sampling. The collected data were then processed and analysed using SEM-PLS.
Results: The results revealed the significance of climate for creativity as a full mediator in the relationship between servant leadership and followers’ creativity, meaning that servant leadership has an indirect influence on followers’ creativity through climate for creativity. These findings suggest that leaders who adopt servant leadership styles can enhance followers’ creativity through climate for creativity.
Conclusion and suggestion: This study found that servant leadership's impact on startup employees' creativity is fully mediated by the perceived climate for creativity. This implies that by fostering a climate supportive of creativity—through flexible work environments, recognition of creativity, and resource provision—servant leaders indirectly enhance employee creativity. Thus, when servant leaders cultivate a climate for creativity, it boosts the creativity of startup employees in their work.
RELIGIOUSITY, LOCATION, AND ISLAMIC WORK PERFORMANCE: THE CONNECTION BETWEEN INDONESIAN AND MALAYSIAN EMPLOYEES
Authors: Fahrullah A'rasy , Anwar Moch. Khoirul , Suryaningsih Sri Abidah , Fahmi Moh. Farih , Masrizal Masrizal , Mohd Noh Mohd Shahid bin
Published: December 2024

Introduction: In today's dynamic era, tight competition urges a comprehensive analysis of company success factors with an emphasis on high-quality human resources, employee performance, religiosity, and workplace location's impact on performance.
Methods: This explanatory research uses a quantitative approach, surveying 259 urban Muslim employees in Indonesia and Malaysia online from May to August 2023 via random sampling and SEM analysis.
Results: Using WarpPLS, this study found that work location significantly affects both religiosity and Islamic work performance, confirming H1 with a coefficient of 0.502 (p-value <0.001) and H2 with a coefficient of 0.573 (p-value <0.001). However, H3 is rejected, as religiosity does not significantly affect Islamic work performance (coefficient 0.082, p-value 0.245).
Conclusion and suggestion: Work location significantly affects employee religiosity and Islamic work performance, with urban and closer locations enhancing these aspects. However, religiosity does not directly impact performance, indicating a complex relationship. Managers should consider location in recruitment, support religious practices, and investigate these dynamics while integrating religious values in training programs.
DIGITAL WALLET TRANSACTIONS: INSIGHT FROM ISLAMIC ECONOMIC AND LEGAL PERSPECTIVE
Authors: Munifatussaidah Asma , Zahara Jihan Nabila , Zein Fuad
Published: December 2024

Introduction: This paper aims to analyze the contemporary problems surrounding digital wallet transactions from the perspective of Islamic economic law and discuss sharia compliance in the issuance and use of digital wallets, the validity of top-up transactions, and the permissibility of benefits such as cashback within the framework of Islamic jurisprudence.
Methods: This paper uses library research methods to collect, explain and analyze data related to digital wallet transactions in the context of Islamic economic law. This has been done using a normative approach and Islamic economic law, supported by descriptive analysis of the previous research, fatwas from the Indonesian Ulema Council (DSN-MUI), and related regulations from Bank Indonesia.
Results: The result of this discussion is that Islamic principles allow financial transactions as long as they do not involve prohibited elements such as usury, uncertainty (gharar), maysir, and israf. Digital wallets can fulfill Islamic principles if they comply with the regulations set by Islamic law.
Conclusion and suggestion: The DSN-MUI fatwa provides guidance on the use of electronic money in accordance with sharia, ensuring that digital wallet transactions are in line with Islamic legal and ethical standards. Digital wallet transactions can use various contracts, such as wadiah and qardh contracts, although there are differences of opinion among scholars regarding their validity. The compliance of digital wallets with sharia must differentiate between conventional electronic wallets and electronic wallets that comply with Sharia.
The Relationship of Knowledge of COVID-19 Vaccines and Implementation of Health Protocols Post COVID-19 Vaccination
Authors: Saraswati Alya , Salvana Sekar Nucifera  , Yusril Hidayat  , Devitasari  , Ariesta Yusuf  , Kiki Antafa N  , Maulidya Nur H  , Namira Shalawasabila  , Wynne Tara  , Sherly Maidasari  , Margareth Liu  , Syafa Revita  , Annisa Riski Azzahrani  , Fatimah Rustika Putri  , Gesnita Nugraheni
Published: December 2024

The COVID-19 pandemic has caused fatalities and brought significant impact on various fields. The vaccine was an important effort to overcome the COVID-19 pandemic. Low knowledge regarding the effectiveness of the COVID-19 vaccine and the Peltzman Effect has the potential to be a cause of ignorance behavior to health protocols. This study was conducted to find out the public's knowledge about the COVID-19 vaccine and the implementation of public health protocols after COVID-19 vaccination. Differences in application before and after vaccination were also studied. This study was a cross-sectional study with accidental sampling techniques. The survey was conducted online using a google form. The inclusion criteria in this study were respondents who were more than 18 years old, have been vaccinated for COVID-19 for at least first dose, domiciled in Java Island. The analysis was conducted using the Mann-Whitney U Test. The There were 456 participants in this study. The results showed that 306 respondents had high knowledge (67.1%), 141 respondents had moderate knowledge (30.9%), and 9 respondents had low knowledge (2.0%). Based on a correlation tests, it was found that there was a relationship between knowledge and public behavior in implementing health protocols (p<0.05). The behavior of implementing health protocols before vaccination was better than after vaccination (p<0.05). Respondents' knowledge of the COVID-19 vaccine significantly affected the behavior of implementing the respondent's health protocols. Health promotion that emphasizes the COVID-19 vaccine and the importance of still implementing post-vaccine health protocols needs to remain encouraged.
Smoking Cessation Awareness Among Active and Passive Smokers in Surabaya
Authors: Guasin Nurshafiqah , Hasanuddin Nur Hafifah , Md Noor Nurul Fathin Athirah , Mohd Idrus Sharifah Nurul Fatin Afiqah , Ahmad Sufie Muhammad Luqman Nurhakim , Nafiisa Aaliyah Fathar  , Elida Zairina
Published: December 2024

Tobacco consumption is still relatively high and increasing compared to the results of 2007 and 2013. The burden of disease in Indonesia is increasing every year, and smoking is one of the leading causes. The critical issue that has to be addressed is a lack of smoking cessation awareness among active and passive smokers. The prolonged use of tobacco products and the exposure of non-smokers to dangerous secondhand smoke both occur as the consequences of this ignorance. This study aimed to assess the willingness to quit smoking and the awareness of existing Nicotine Replacement Therapy (NRT) or QUITLINE Program. The subjects were chosen by convenient sampling for those who met the inclusion criteria, including Surabaya citizens aged 18 years and above, active smokers and passive smokers due to living/staying with active smokers. The data were collected using a self-administered questionnaire. The data were analyzed descriptively using IBM SPSS software version 26.0. About 106 subjects participated in the study consists of 77% male, 23% female, with ages ranging from 19 to 62 years. The data showed that 57.55% (n=61) of smokers, 42.45% (n=45) non-smokers.  Of 106 respondents, 67 (63.2%) had never heard about Nicotine Replacement Therapy (NRT) and 98.4% (60 smokers) had never heard of QUITLINE Program. Encouragingly, 63.9% (39 smokers) of the smokers were aware of the dangers of smoking. From this study, it can be concluded that the awareness of smoking cessation among the residents in Mulyorejo, Surabaya, was high. However, some of them were not convinced yet to stop smoking because their intention to quit smoking was low.
SOCIAL RETURN ON INVESTMENT (SROI) ANALYSIS OF THE ELECTRIC MOTOR CONVERSION TRAINING PROGRAM IN NORTH LAMPUNG
Authors: Redaputri Appin Purisky , Barusman M Yusuf S
Published: December 2024

Converting conventional motors into electric vehicles can reduce dependence on fossil fuels. The conversion process involves engine replacement, charging system installation, and vehicle structure modification. The conversion program was carried out involving workshops and vocational high school students. The Social Return on Investment (SROI) method was employed to measure the social and economic impacts of the program, involving impact identification, measurement, monetization, cost comparison, and analysis. The PLN Cares program undertook motor conversion with the aim of improving sustainability and quality. The research problem and objectives focused on measuring the SROI in the electric motor conversion program. The research method employed a qualitative approach with data collection techniques through in-depth interviews, focus group discussions, observations, and literature studies. Data were continuously analyzed during and after collection. SROI calculations involved initial investment capital input and impact value, resulting in an SROI ratio of 5.03. The research results indicated that the PLN Cares program had a significant social impact, with an SROI ratio indicating a profitable investment value. Conclusions and recommendations involved maintaining the working mechanisms, synergy among stakeholders, and using the program as a guide for similar projects in the future.
PENGUKURAN pH, DISSOLVED OXYGEN (DO), DAN TOTAL DISSOLVED SOLID (TDS) PADA SUNGAI WILAYAH INDUSTRI COR LOGAM KABUPATEN HULU SUNGAI SELATAN
Authors: Kartini Kartini , Rizani Ahmad , Fajar Reza Adhi , Saptarini Dessy Lestari , Rizhan Muhammad
Published: December 2024

Water is essential for human life, used daily for drinking, cooking, bathing, washing, and various other purposes. The presence of industrial waste can significantly impact the water quality of rivers located in industrial areas. In North Daha District, South Kalimantan, there is a metal casting industry that discharges its waste into a nearby river. Therefore, measuring the water quality of the river is necessary to determine the level of pollution caused by industrial waste. The objective of this study is to obtain parameters from water quality tests, such as pH, dissolved oxygen (DO), and total dissolved solid (TDS), to assess the river's condition before and after metal casting processed. Additionally, the study aims to compare the test results against water quality standards for public consumption. The research method involves direct measurement of river water using a multiparameter water quality testing instrument. The test results before metal casting processed are pH 6,33 – 6,47; DO 1,03 – 2,18 ppm; and TDS 45 – 65 ppm. The test result after casting processed are pH 6,57 – 6,85; DO 6,66 – 13,19 ppm; and TDS 43 – 48 ppm. Comparing from PP RI Number 82 (2001) that the metal casting industry activities have water criterion within the range allowable values. That indicate the industry do not contaminate the river in the industrial area. The river pollution is primarily caused by tidal phenomena, particularly during low tide conditions.
Adopsi E-Katalog Pengadaan Barang Dan Jasa Pada Umkm Kabupaten Banjar Menggunakan Technology Accaptence Model (TAM)
Authors: Rahmatullah Ahyar , Budiman Arief
Published: December 2024

The purpose of this research is to explain and analyze E-Catalog Adoption in Banjar
Regency UMKM using the Technology Acceptance Model (TAM) which consists of exogenous
variables namely Perceived Usefulness, Perceived Ease of Use and endogenous variables
namely Attitude Toward Using, Behavioral Intention and Actual Use.
The respondents in this study were 341 UMKM registered in the Banjar Regency E-
Catalog This research uses the SEM (Structural Equation Model) analysis method using
Partial Least Square (PLS).
The results of this research show that 4 hypotheses are accepted, namely the Perceived
usefulness variable has a significant effect on Attitude Toward Using, Perceived Ease of Use
has a positive and significant effect on Attitude Toward Using, Perceived Ease of Use has a
positive and significant effect on Behavioral Intention, and Behavioral Intention has a positive
and significant effect. significant to Actual Usage. Meanwhile, there were 2 hypotheses that
were rejected, namely Perceived Usefulness had no significant effect on Behavioral Intention
and Attitude Toward Using had no significant effect on Behavioral Intention of the Banjar
Regency UMKM E-Catalog.
Ancient DNA research may be conducted in the absence of consent from descendant communities
Authors: Moosa Thaakira , Ewuoso Cornelius
Published: December 2024

Background: Ancient deoxyribonucleic acid (aDNA) research studies the genomes of human ancestors. Since the archaeological remains that carry this aDNA are often those of the non-living ancestors of living humans, one less explored question is whether aDNA research ought to be permissible in the absence of informed consent of descendant communities. We interrogate this question.

Method: To address this question, this paper is a primarily conceptual paper that draws on moral norms arising from pre-existing — albeit competing — formulations of harmony in African moral philosophy. This methodological approach is not uncommon and has been accepted as a valid research method.

Result: The paper’s methodological approach yields the conclusion that it is ethically permissible to conduct aDNA research on human archaeological remains in the absence of informed consent from descendant communities or individuals. Although we justify the ethical permissibility of conducting research without consent, we also emphasise the importance of consultation with descendant communities — where they are known — and the researchers’ responsibility to share benefits with them before, during, and after aDNA research.

Conclusion: The sort of aDNA research that this paper considers permissible is that which is likely to enhance harmonious relationships in relevant ways. aDNA research is advancing rapidly and in proportion to technological advances. To ensure that aDNA research in a more technologically advanced world is undertaken in ethically permissible ways, global research guidelines would be required. Future studies can focus on articulating such guidelines.
Technology of manufacturing copper and bronze tools of the Petrovka Culture of the Southern Trans-Urals and Middle Tobol region
Authors: Degtyareva A.D.
Published: December 2024

The article presents the results of metallographic analysis of the Petrovka Culture tools from the southern Trans-Urals and Middle Tobol River region of the 19th–18th centuries BC (47 items). A certain correlation has been determined between the functional purpose of an item, the type of raw material, and the tool manufacturing scheme. The tools were mainly made of copper contaminated with impurities, obtained from oxide-carbonate ores with the addition of chalcocite-covellite minerals. A butted axe, sickles, knives with handles, tanged chisels, hooks, and some awls were made of copper, both by casting in a mold with subsequent finishing and by forming forging. Copper tools obtained by casting often had casting defects — shrinkage cracks and warping of the metal. In most cases, the tools were finished either in the regime of incomplete hot forging at 300–500°C, or hot forging at 600–800°C and pre-melting temperatures of 900–1000°C. During the Petrovka period, tin and tin-arsenic bronze started being used for manufacturing adzes, chisels, handled knives, the majority of awls, needles, spear-heads, and arrows. More progressive types of alloys in terms of fluidity, filling mold without defects in the form of low-alloy tin and tin-arsenic bronzes (Sn up to 7%, As up to 4%) came from related tribes of the Petrovka Culture of Saryarka, possibly from the Petropavlovsk Ishim region. The resulting castings were of high quality with smooth surface without metal warping defects. Subsequent finishing was carried out by selecting optimal heat treatment regimes mainly at 600–800°C or 900–1000°C, as well as using incomplete hot forging at 300–500°C. The hardness of the tools finished by forging with heating significantly exceeded the microhardness of the processed copper by 1.5–2 times.
The use of electromagnetic and laser scanning methods at the sites of the Bronze to Early Iron Age transition in the Tura-Pyshma interfluve (Trans-Urals)
Authors: Zimina O.Yu. , Kostomarov V.M.
Published: December 2024

The article introduces into scientific discourse the results of reconnaissance studies of the hillfort of Plamya Sibiri 1, located in the Tura-Pyshma interfluve. The hillfort belongs to the Plamya Sibiri complex of sites located on the right bank of the Tura River; it is attributed to the eastern variant of the Itkul Culture and, within the framework of its chronology, is dated to the end of 8th–7th centuries BC. Geophysical survey (electromagnetic and airborne laser scanning) and excavations of one of the structures have been carried out at the site. During the investigation of the Plamya Sibiri 1 hillfort, materials typical for the sites of the eastern variant of the Itkul Culture were obtained. The remains of a partially surveyed building of frame and pillar structure without a pit, which left a hole in the ground of 0.2–0.4 m in diameter and 0.15–0.3 m in depth, were recorded on the mainland. The buil-ding was surrounded by pits-quarries, which served for taking soil for filling walls. No hearth was found within the investigated part of the structure. Fragments of ceramic vessels with an appearance characteristic to the second type of pottery of the Itkul Culture (Iset Culture, according to V.A. Borzunov) were found in the territory of the structure. The radiocarbon date GV-03320 2865 ± 29 BP (non-calibrated), obtained from the charcoal from the remains of the structure, belongs to the turn of the Bronze and Iron Ages. The first results of electromagnetic and laser scanning have also been obtained. The use of LiDAR to search for large, poorly defined in the landscape structures of the eastern variant of the Itkul Culture has shown its high efficiency. The structures (remains of ditches, ramparts and above ground structures) are well traced under the forest canopy, even despite their minimal parameters in terms of relief. Interesting are the results of electromagnetic scanning, first of all, from the methodological point of view, since not only they show certain features of the layout and architecture of the settlement, but also replenish the experience of using this type of devices in alluvial soils. It was possible to determine that this type of research is effective in terms of detecting anomalies characterizing individual elements of residential and fortification structures, which can be recorded at frequencies associated with the upper horizons — no deeper than frequencies of 13 and 12, which have shown to be the most informative. The issues of dating and cultural affiliation of the monuments of this circle require further research.
Pottery traditions of the Old Bering Sea Culture of the Chukchi Peninsula (based on materials from the Chini cemetery)
Authors: Selin D.V. , Lebedintsev A.I. , Grebenyuk P.S. , Fedorchenko A.Yu
Published: December 2024

Here we present the results of the technical and technological analysis of pottery from one dugout (4 ves-sels) and 22 graves (23 vessels) of the Chini cemetery (Chukchi Peninsula). We found that potters of the Old Bering Sea Culture used mainly ferruginous, weakly sanded clay in the production of pottery. Two recipes for moulding clay were found in the dugout and five in the burial ground. The construction of the hollow body was made by patchwork layering, presumably on a base mould. Smooth or embossed knockout was used for shaping. The surfaces were worked by troweling. Five vessels from different burials demonstrate the effect of residual plas-ticity of molding mass. The area of the Chini cemetery was used by different groups of the Old Bering Sea Culture with different pottery traditions. At least three different groups can be distinguished, which used different recipes for the moulding mass. The absence of hybrid recipes indicates that there was no mixing of pottery skills between these groups. Similar pattern is also characteristic for the pottery found in the dugout. The spatial context of the cemetery shows that different groups of the Old Bering Sea Culture developed different parts of the Chini ceme-tery. Group 1 built their tombs in the northeastern part of the cemetery, while Group 2 — mainly in the central part. Burials of Group 3 are located on the periphery of the cemetery. Pottery of groups 2 and 3 existed at the same time, as two vessels made from two different recipes were found in burial 8. Presented information reveals the dynamic history of a distinct group of Neo-Eskimos who left the Chini cemetery. These data indicate a signifi-cant influence of ancient populations related to Paleo-Eskimos and ancestors of the Chukchi on this group, and also suggest participation of women of various communities in pottery production.
Education for social sustainability in early years: towards an inclusive perspective – a literature review
Authors:   University of Dundee, Garcia Manas Carmela
Published: December 2024

This paper begins by examining the broad literature that emphasises the need for sustainable education in early childhood education. It then briefly examines previously published research initiatives concerning the three dimensions of sustainability: environmental, social and economic, in early childhood education. It acknowledges that this is a broad issue and globally, there is much to be done socially. Finding strategies to instil sustainable attitudes and behaviours that require fundamental social skills, such as collaborative working and empathy in children at an early age, is crucial if we want them to become environmentally conscious instead of unconsciously adopting materialistic lives. In conclusion, the paper highlights the need for education for sustainability (EfS) to address its social dimension competently and for society to adopt a more inclusive perspective and view children as active contributors.
Condicionantes demográficos das transferências de renda e estratégias de sobrevivência rural na Amazônia: autonomia ou dependência?
Authors: Barbieri Alisson F. , Teixeira Magalhães Soares Helena
Published: December 2024

O debate sobre a eficácia do acesso aos benefícios socioassistenciais como fator de superação da pobreza e vulnerabilidade tem sido marcado por visões divergentes em termos de geração de autonomia e empoderamento, ou como a perpetuação de uma relação de dependência que anula as capacidades individuais e entrega da responsabilidade ao Estado. Uma lacuna nesse debate é compreender os efeitos dos benefícios considerando a dinâmica demográfica domiciliar e as condições específicas do meio rural, especificamente das unidades domiciliares de produção, e suas decisões de uso da terra e alocação de mão de obra. O objetivo do artigo é avaliar o impacto do acesso aos benefícios socioassistenciais sobre as estratégias de subsistência das famílias rurais, particularmente as decisões de uso da terra e alocação de mão de obra domiciliar. Avalia-se, ainda, como e se a composição demográfica das famílias exerce efeito mediador sobre esse impacto. É proposto um estudo de caso baseado em pesquisa domiciliar em 2015 no município de Machadinho, Rondônia, utilizando uma combinação de estatísticas descritivas, testes de diferenças de médias e probabilidades acumuladas por meio do estimador Kaplan-Meier de manutenção da produção rural com o recebimento de benefícios. Os resultados, ao indicarem que tamanho e composição demográfica são significativos para determinarem tanto a dinâmica dos benefícios quanto a relação destes com as estratégias de subsistência rurais, inclusive com segurança alimentar e investimento produtivo rural, reforçam a importância dos benefícios como elemento de autonomia produtiva e de fortalecimento das capacidades individuais e coletivas de domicílios em situação de vulnerabilidade.
Field Development Optimization for Low-Productivity Gas Wells under Intermittent Production
Authors: Tian Wei , Liu Yi , Li Xuri , Jia Youliang , Wang Yixuan , Li Li , Zhao Zhengyan , Ding Weihong , Zhou Wenxin , Sun Wenyue
Published: December 2024

For low-productivity gas wells, insufficient formation pressure leads to issues like liquid loading and decreased gas production rates. Intermittent production, where wells are periodically shut-in and open, is a common approach to address these problems. This strategy allows formation pressure recovery during the shut-in period, which leads to a higher gas rate during the production period to carry liquids out of the wellbore. However, unreasonable operating schedules can result in problems such as insufficient formation pressure recovery and issues of liquid loading. Therefore, an optimization method for intermittent gas wells based on particle swarm optimization (PSO) algorithm and deep-learning model is proposed. The PSO algorithm determines the optimal schedule, while the deep-learning model forecasts key cycle parameters for these potential schedules. A total of 110,000 key cycle parameters dataset extracted from high-frequency raw data of 304 wells is used in the model training process. The test results show that the trained model accurately predicted all selected key cycle parameters, with R2 values ranging from 0.91 to 0.99. Finally, the optimization method was applied to 100 wells in the gas field for real-time validation. Field application results show a success rate exceeding 95%, demonstrating the effectiveness of the proposed method for real-time production optimization of low-productivity gas wells under intermittent production.
Assessment of Urban Deprivation Situation in Border-Settlements in Nigeria: The Lagos and Ogun Experience
Authors: OLOWOPOROKU Oluwaseun , DARAMOLA Oluwole , OLATUNJI Jaiyeoba
Published: December 2024

Understanding people’s experiences with their living condition is essential in reducing inequality in cities. This study examined urban deprivation in border settlements of Lagos and Ogun States with a view to providing information capable of enhancing the living condition of residents in the study area. Sample was selected using systematic sampling. Indexes tagged Residents Importance Index (RII) and Residents Satisfaction Index (RSI) were used to measure the importance residents attached to and the satisfaction residents derived from attributes of their settlements. The study revealed that residents in the border settlements of the two states experienced physical, social, and economic form of urban deprivation. It further revealed that across the border settlements of the two states, residents attached high importance to the facilities and services that culminated into the settlement’s attributes, however, they derived low satisfaction from them. Also, the study established that physical facilities across the two states were in poorest conditions compared to social and economic facilities and all this indicates a level of urban deprivation in the study area. The study recommended government intervention in the upgrading of the condition of existing facilities as well as introduction of public private partnership in the provision, upgrade, and maintenance of public facilities in the study area.
Synergistic effect of inhibiting CHK2 and DNA replication on cancer cell growth
Authors: Coquel Flavie , Ho Sing-Zong , Tsai Keng-Chang , Yang Chun-Yen , Aze Antoine , Devin Julie , Chang Ting-Hsiang , Kong-Hap Marie , Bioteau Audrey , Moreaux Jérôme , Maiorano Domenico , Pourquier Philippe , Yang Wen-Chin , Lin Yea-Lih , Pasero Philippe
Published: December 2024

Cancer cells display high levels of oncogene-induced replication stress (RS) and rely on DNA damage checkpoint for viability. This feature is exploited by cancer therapies to either increase RS to unbearable levels or to inhibit checkpoint kinases involved in the DNA damage response (DDR). Thus far, treatments that combine these two strategies have shown promise but also have severe adverse effects. To identify novel, better-tolerated anticancer combinations, we screened a collection of plant extracts and found two natural compounds from the plant, Psoralea corylifolia, that synergistically inhibit cancer cell proliferation. Bakuchiol inhibited DNA replication and activated the checkpoint kinase CHK1 by targeting DNA polymerases. Isobavachalcone interfered with DNA double-strand break (DSB) repair by inhibiting the checkpoint kinase CHK2 and DNA end resection. The combination of bakuchiol and isobavachalcone synergistically inhibited cancer cell proliferation in vitro. Importantly, it also prevented tumor development in xenografted mice. The synergistic effect of inhibiting DNA replication and CHK2 signaling identifies a vulnerability of cancer cells that might be exploited by using clinically approved inhibitors in novel combination therapies.
Musical Tempo Matters? Impact of Musical Rhythm on Blood, Physiological and Welfare Parameters in Stabled Horses
Authors: de Oliveira Fernanda Yumi Ueno , Caldara Fabiana Ribeiro , Odakura Agnês Markiy , Burbarelli Maria Fernanda de Castro , Ouros Caio César dos , Paz Ibiara Correia de Lima Almeida , Braz Jaqueline Murback , Garcia Rodrigo Garófallo
Published: December 2024

The aim of this study was to evaluate the effects of two styles of classical music, based on different tempos (BPM), on the physiological and blood parameters of horses during social isolation and restriction of movements. First experiment were carried out using nine horses of no defined breed, distributed in Control, Slow-tempo music and Moderate-tempo music .For social isolation and restriction of movement, the animals were housed daily in individual stalls for two hours and exposed to the stimuli for 60 minutes, and eye temperature, heart rate, and respiratory rate were assessed.The second experiment were carried out using ten horses of no defined breed were used, distributed in a randomized design in treatments: Slow-tempo Music and Moderate-tempo Music. Blood samples were taken at the start and end of the experimental period to assess hematological and biochemical parameters and serum serotonin levels. Horses exposed to moderate-tempo music showed an increase in serum calcium levels, mean corpuscular hemoglobin (MCH), and total hemoglobin concentration, as well as a reduction in lymphocytes.Both types of music led to a significant increase in serotonin levels after one week of stimulation. Both musical rhythms are appropriate for promoting the well-being and health of stabled horses.
Optimizing Pt catalyst performance for oxygen reduction reaction via surface functionalization of Vulcan XC-72R carbon black support
Authors: Najafli Erkin , Grossberg Maarja , Mikli Valdek , Walke Peter , Ratso Sander , Kruusenberg Ivar
Published: December 2024

In this study, the impact of Vulcan XC-72R carbon black support pre-treatment on the oxygen reduction reaction performance of the Pt catalyst was investigated. Catalysts were synthesized via the polyol method using ethylene glycol, with different pre-treatment pathways (with H2O2 and HNO3 solutions) applied to the carbon black for surface functionalization. Additional samples using non-treated XC-72R and N-doped XC-72R were prepared for comparison, alongside a commercial Pt/C catalyst. Electrochemical characterization revealed that H2O2 pre-treatment resulted in the largest electrochemically active surface area and enhanced oxygen reduction reaction activity, surpassing both non-treated and commercial catalysts. The H2O2-treated catalyst exhibited superior stability during accelerated stress testing. SEM and XRD analyses confirmed the presence of Pt nanoparticles with sizes between 2.93-4.46 nm (that are considered optimal) for the H2O2-treated sample. Raman spectroscopy indicated that H2O2 pre-treatment led to a less ordered carbon structure with more defects, which is favorable for improved Pt utilization. It was concluded that H2O2 pre-treatment of XC-72R significantly improves the catalytic activity of the Pt catalyst, demonstrating the potential for optimizing Pt loading while maintaining desired ORR kinetics in fuel cell applications.
Development of shallow-water contourite deposits on the muddy continental shelf off southeastern Korea
Authors: Chun Jong-Hwa , Ha Jiho , Shin Jungkyun , Um In Kwon
Published: December 2024

On the southeastern continental shelf of Korea, within the Korea Strait Shelf Mud deposit, seafloor undulations trending north-northwest‒south-southwest have been identified offshore of Ulsan. This study utilized multibeam echo sounding, two- and three-dimensional (3D) high-resolution CHIRP seismic surveys, and piston core analysis to investigate the formation and timing of these undulations on the muddy continental shelf. The multibeam data revealed irregular seafloor undulations aligned with the bathymetric contours, and the sea-bottom reflected amplitude of 3D CHIRP profiles identified elongated mounds within this region. The surface undulations extend approximately 30 km at a depth of 46‒56 m, running parallel to the bathymetric contours. These features vary laterally in width from 50 to 400 m and including small, elongate mounds. Core 20MAP-P05, which is located closer to the coast, contains coarse-grained typhoon deposits from the high-energy environment above a storm wave base, dating to 225‒287 cal yr BP. However, this interval is absent in core 20MAP-P04, which was sampled from the undulating seafloor at depth of 51.2 m. This core contains vertical burrows, 10‒20 mm in diameter, dating to around 183 cal yr BP at a depth of 220 cm, suggesting the rapid redeposition of resuspended sediments. These results indicate the formation of elongate mounds in an area with seafloor undulations off Ulsan, and that sudden re-sedimentation on the muddy continental shelf occurred around 183 cal yr BP due to the influence of contourite currents beneath the storm wave base.
Researching on Insulator Defect Recognition based on Context Cluster CenterNet++
Authors: Meng Bo
Published: December 2024

The existing UAV inspection images are faced with many challenges for insulator defect recognition. A new multi-resolution Context Cluster CenterNet + + model is proposed. First, this paper proposes the Context Cluster method to solve the problem of low recognition accuracy caused by non-uniform distribution of targets. The cluster region is used to identify and predict the location of the target, and the improved loss function is used to modify the cluster center. Secondly, this paper uses deformable convolution operator (DCNv2) combined with path aggregation network (PAN) to carry out deformable convolution operation on the image, and accurately predicts the regression box and key point triplet (KP), so as to improve the accurate positioning of the target position of any shape and any scale. The sensitivity of the model to target scale change and deformation is reduced, and the recognition accuracy of the model is improved. Then, Bhattacharyya distance is used to calculate the triplet prediction loss of key points and the target center point offset loss, so as to significantly improve the positioning accuracy of the same target in different frames. Finally, experiments are carried out on the MS-COCO dataset and the National Grid standardized UAV inspection insulator image dataset.
Random Impact Force Localisation Enabled by Weighted Reference Database Method
Authors: Qiu Binbin , Liu Siqi , Li Weidong , Feng Chunhua , Zhu Yu , Liu Haoran
Published: December 2024

The mechanical properties of an engineering structure can be substantially influenced by a random impact force (RIF), which may compromise the integrity and safety of the structure. Nevertheless, accurately localising the RIF applied to a structure presents a significant challenge. To address this issue, this study introduces a novel method known as the weighted reference database method (WRDM). Its innovations are reflected in three aspects: (i) constrained by the sparse construction of a reference database, bicubic interpolation is utilised to increase the reference impact point density and improve the localisation accuracy; (ii) a weighted random impact localisation framework is constructed, in which a cosine distance variant is chosen as the weight to further improve the localisation accuracy; and (iii) to overcome the region limitation of interpolation, the boundary range of the WRDM is extended. Experiments on a suspended rectangular plate were conducted to validate and demonstrate the effectiveness of the WRDM in terms of localisation accuracy. The experimental results indicate that the average absolute error of the method is 16.67 mm (the interpolation interval size is 2 mm and the prioritisation point number (PPN) is 108), and its localisation accuracy is higher than that of previously published methods (21.54 mm for PRMCSM; 20.80 mm for the hybrid method).
Bioinformatic Analysis of the Protective Effects of Dexmedetomidine and Thrombopoietin against Hypoxia/Reoxygenation-Induced Injury in AC16 Cells
Authors: Xing Cuiyan , Wu Mingyi , Zhou Xiaoyang , Gong Benhang
Published: December 2024

Objective: To investigate the protective mechanisms of dexmedetomidine (Dex) and thrombopoietin (TPO) against hypoxia/reoxygenation (H/R)-induced myocardial injury.
Methods: Human cardiomyocyte AC16 cells were subjected to hypoxic conditions and treated with Dex and TPO. Cellular responses were assessed through proliferation, apoptosis, and autophagy assays. RNA sequencing and bioinformatic analyses were conducted to identify differentially expressed genes, followed by functional pathway enrichment analysis.
Results: Dex and TPO significantly promoted cell proliferation, reduced apoptosis and autophagy, and inhibited caspase-3 activity and LC3B expression. Both agents induced changes in gene expression, with pathway enrichment analysis revealing involvement in MAPK, TGF-β, and TNF signaling pathways. While both treatments demonstrated overlapping effects, each exhibited unique gene regulation mechanisms.
Conclusion: Dex and TPO mitigate H/R-induced myocardial injury through complex gene regulatory mechanisms, offering potential intervention strategies for myocardial ischemia-reperfusion injury (MIRI).
Improved European heat event simulation by resolving oceanic-mesoscale eddies
Authors: Krueger Julian , Kjellsson Joakim , Lohmann Katja , Matei Daniela , Kedzierski Robin Pilch
Published: December 2024

Owing to the rapid increase of European heat event occurrences over the past decades, the understanding of their physical drivers has become increasingly important for the scientific community. Recently, it has been shown that cold North Atlantic sea surface temperatures (SSTs) are strongly linked to European heat events such as in summer 2015 and 2018. Thereby, an accurate representation of this connection in climate models is crucial for a more realistic European heat event simulation. Here, we investigate the connection by employing seven global coupled climate models, from which six models are embedded in the High Resolution Model Intercomparison Project (HighResMIP). High-resolution versions of these models capture mesoscale eddies, thus enabling to study their impact onto the (North Atlantic SST- European summer temperature extremes) connection. Our results show that high-resolution model versions better capture the North Atlantic trough and the downstream ridge anomalies over central Europe, although still underestimated in intensity
and duration compared to observations. Improvements in high-resolution configurations are due to the increased ocean model resolution, which reduces the North Atlantic surface biases and improves air-sea interactions, thus having implications for the prediction and projection of climate extremes in the North Atlantic-European region.
Evaluation of an artificial intelligence model for identification of obstructive hydrocephalus on computed tomography of the head
Authors: Ghatak Ankita , Newbury-Chaet Isabella , Mercaldo Sarah , Chin John , Halle Madeleine , L'Italien Eric , MacDonald Ashley , Schultz Alex , Buch Karen , Conklin John , Mehan William , Pomerantz Stuart , Rincon Sandra , Bizzo Bernardo , Hillis James Michael
Published: December 2024

Introduction:
Obstructive hydrocephalus is a critical radiographic finding requiring emergent treatment. Its identification on head computed tomography (CT) by an artificial intelligence (AI) model could facilitate sooner life-saving interventions, although there are common co-occurring findings including intracranial hemorrhage that can confound this interpretation. This study assessed the accuracy of an AI model (Annalise Enterprise CTB) at identifying obstructive hydrocephalus including in the presence or absence of other findings.
Methods
This retrospective cohort included 177 thin (≤ 1.5mm) series and 194 thick (> 1.5 and ≤ 5mm) series from 200 non-contrast head CT cases. These cases were obtained from patients aged ≥ 18 years at 5 hospitals in the United States. Each case was interpreted independently by up to three neuroradiologists. Each series was then interpreted by the AI model.
Results
The AI model performed with area under the curve 0.988 (95% confidence interval (CI): 0.971 to 0.998) on thin series and 0.986 (95% CI: 0.969 to 0.997) on thick series. These results were broadly maintained in subgroups for the presence or absence of intracranial hemorrhage, parenchymal abnormality and ventricular drain, and across demographic and scanner manufacturer subgroups.
Conclusions
The AI model accurately identified obstructive hydrocephalus in this dataset. Its performance in subgroup analyses reflected its robustness.
مشروعية تطبيق القوانين العراقية الملغاة في إقليم كوردستان: القوانين الخاصة أنموذجاً
Authors: شریف صالح رضوان , شریف صالح محسن
Published: December 2024

ينص الدستور العراقي الدائم (2005) على أن العراق دولة اتحادیة ونظام الحكم فيها جمهوري نيابي (برلماني)، ويقر بإقليم كوردستان اقليماً اتحادياً. وقد مكّن هذا النظام السلطات الاتحادية (المركزية) وإقليم كردستان الحصول على سلطات التشريعية والتنفيذية والقضائية. الوظيفة الأساسية لمجلس النواب العراقي (البرلمان) هي تشریع القوانين الاتحادية، وبالمقابل يحق لبرلمان كوردستان ‌إصدار القوانين وتعديل القوانين الاتحادية، باستثناء المسائل التي تقع ضمن الاختصاصات الحصرية للحكومة الاتحادية. مشكلة هذه الدراسة تکمن فی القوانين التی كانت معمول بها سابقاً ونافذاً‌في العراق، بید أنها ألغيت لاحقاً من قبل مجلس النواب العراقي من خلال تشریع قوانين جديدة؛ ورغم إلغائها بحجة عدم اصدار قوانين لإنفاذ القوانين الجديدة لا تزال هذه القوانين الملغاة سارية المفعول في إقليم كردستان. لذا فإن الهدف الرئيسي من هذه الدراسة هو بيان مدى شرعية تطبيق القوانين العراقية التي ألغاها مجلس النواب العراقي وهی لا تزال نافذة في إقليم كوردستان، فضلا عن عرض بعض القوانين الخاصة المتعلقة بهذه القضية. وخلصت هذه الدراسة المبنية على المنهج التحليلي والمیداني إلى أن المواد والأحكام الدستورية ذات الصلة بموضوع بحثنا غير واضحة وغیر قابلة لحل مشكلة الدراسة بشكل تام، فمن الناحية العملية ينشأ صراع قانوني وفقهي، حيث يضفي إقليم كردستان الشرعية على تطبيق القوانين الملغاة، ولكن من جهة أخرى تنفي السلطات الاتحادية العراقية شرعيتها، وتطالب بتطبيق القوانين الجديدة، وهذا أصح إلى حد ما من حيث المنطق والدستور.
قراءة قانونية لاستعمال الحوافز الضريبية في قانون الاستثمار الاتحادي رقم (13) لسنة 2006م المعدل وقانون الاستثمار في اقليم كردستان رقم (4) لسنة 2006م
Authors: سامي عواد عبدالمحمدي شامل
Published: December 2024

من نافلة البيان أن الحوافز الضريبية عدًت وفق الفكر المالي الحديث أداة من أدوات التنمية الاقتصادية والمالية والاجتماعية ؛ وفق طبيعة ونوع الحوافز الضريبية المستخدمة في الدولة ومدى ملائمتها ومرونتها على الاستقرار المالي والاقتصادي ، وفي ذات الوقت هي وسيلة لجذب الاستثمار الوطني والأجنبي، من حيث اثرها البارز في زيادة حجم التشغيل والعمل والإنتاج والادخار ، والحد من مشكلة الفقر والبطالة في الدول، كذلك تسهم في الحد من الركود الاقتصادي من خلال خلق استقرار اقتصادي متوازن داخل الدولة ، وتسعى إلى رفع مستوى النمو الاقتصادي وجذب الأموال الأجنبية ؛ شريطة أن تقترن هذه الحوافز الضريبية بتشريع قانوني ناجع ؛ يسعى إلى تحقيق اهداف السياسة الضريبية وتحقيق نظامها الضريبي المنشود الذي يصبو في هذا المقام إلى جعل القوانين والتشريعات الضريبية الاتحادية وفي إقليم كردستان عامل جذب وتحفيز للاستثمار الأجنبي والوطني وتشجيع الإدارة الضريبية على استخدام الحوافز الضريبية في قوانينها وتشريعاتها الضريبية وفق برامج رصينة تسعى من خلالها لتفعيل النصوص القانونية وفق الشكل السليم ؛ إذ خلصت الدراسة إلى تحديد مكامن النقص في قانون الاستثمار الاتحادي وقانون الاستثمار في إقليم كردستان من أجل تعديلها مستقبلاً بما يسهم في جعلها قوانين وتشريعات ضريبية جاذبة للاستثمار بكل ايجابياته .
الحماية القانونية للبيئة في العراق ( دراسة تحليلية)
Authors: ابراهيم زهراو دعاء
Published: December 2024

إن التحديات الكبرى التي يواجهها العراق تكمن في ارتفاع معدلات التلوث البيئي، إذ اصبح التلوث بمثابة ضريبة يدفعها الانسان نتيجة التطور الصناعي مما أدى الى زيادة في معدلات الأنشطة الخطرة على البيئة، فكان لا بد من وضع أسس قانونية للحد من الضرر البيئي.

وان َّدستور جمهورية العراق لسنة 2005، قد إقر بحماية البيئة والتنوع الاحيائي وبصورةٍ صريحة، وبذلك على سلطات الدولة توفير بيئة نظيفة للأفراد وحمايتها من أي خطر يهددها، وبالفعل تم تشريع قانون حماية وتحسين البيئة رقم (27) لسنة 2009، وكان هذا القانون يهدف الى حماية البيئة ، فضلاً عن الإجراءات التي تتخذها الجهات التنفيذية للحد من التلوث والضرر الذي يصيب البيئة، وكذلك أقر بعقوبات على كل من يخالف احكامه.
استثمار الطاقة الشمسية في تشغيل المولدات الكهربائية الاهلية
Authors: محمد نجيب جرجيس البياتي سحر محمد نجيب جرجيس البياتي , وليد ابراهيم يسرى
Published: December 2024

التغلب على ازمة الكهرباء التي يتزود بها المواطن من المولدات الاهلية ومواجهة التحديات المستقبلية المتمثلة بتوفير الكهرباء بشكل مستمر وشامل لكل مناطق العراق يتحقق بالاعتماد على الطاقة الشمسية لتشغيل هذه المولدات كمصدر رئيسي بدلا من الوقود الذي غالبا ما توفره الدولة لأصحابها لمساعدتهم في الحصول عليه بسعر مدعوم من اجل الاستمرار بالتشغيل لتلبية حاجة المواطن من الكهرباء لمواجهة حرارة الصيف القوية التي يتميز بها جو العراق . وهذا يحقق فوائد كثيرة منها حماية البيئة من التلوث نتيجة استخدام الوقود لتشغيل المولدات، والمحافظة على صحة الانسان، كما يحقق فائدة اقتصادية بتوفير مبالغ ضخمة تبذلها الدولة لاستيراد الكهرباء من الخارج، اذ يتمتع العراق بتركيز اشعاعي شمسي ولأشهر طويلة ضمن فصول السنة، يمكن استثمار هذه الطاقة بتفأوض الدولة مع شركات مختصة وطنية أو اجنبية، فتشارك الدولة بهذا الاستثمار من خلال تقليل الرسوم الجمركية على استيراد شرائح الطاقة الشمسية من قبل اصحاب المولدات، وتستوردها الدولة وتبيعها لهم بسعر مدعوم، أو تمنح امتياز لشركات القطاع الخاص للاستثمار لتحقيق غاية وهي توليد الكهرباء للمواطن .