bluuebunny/crossref_metadata_2025 huggingface dataset:
La Educación Superior del futuro en el Ecuador y sus desafíos en los nuevos procesos de enseñanza aprendizaje
Authors: Ramos Burgos Washington Alejandro , Chang Muñoz Walter Lenin , Zea Perez Manuel Honorio
Published: April 2022

La educación es un proceso multidireccional mediante el cual se transmite el  conocimiento, a lo largo de la historia  a la educación  siempre ha estado presente con la finalidad de ir formando al ser humano. En la actualidad la educación no solo se produce en las aulas como en los tiempos antiguos, si no que en cada lugar, situación se produce la educación, cada día aprender no solo es un proceso que se realiza en el aula,  los seres humanos adquirimos conocimiento de cada persona, noticia, o información a las que tengamos acceso en tiempo real. Esto se debe a que el internet actualmente es un servicio que se considera básico para la sociedad, puesto a que pasamos todo el tiempo en línea y esto es una gran contribución hoy en día en los procesos que realizamos en nuestro diario vivir como son el trabajo, en nuestra vida social, y más importante nuestra vida estudiantil, puesto a que debemos de están es constante crecimiento académico, teniéndolo como gran aporte en la enseñanza y aprendizaje de la educación superior. Internet es considerada como una de las tecnologías más importantes puesto que se ha introducido muy rápidamente en el campo educativo,  la web social pone a nuestra disposición un sin número de herramientas tecnológicas que aportan a las actividades educativas, colaborativas, a la pedagogía y al cognitivismo, facilitando a los estudiantes y docentes los medios y nuevos canales de aprendizaje. Entre estas herramientas tenemos los las redes sociales, wikis, MOOCS, realidad virtual, contenidos multimedia, comunidades, etc.  En este artículo realizaremos un estudio analítico de cada una de estas herramientas de aprendizaje y de qué manera esta inciden en la educación superior de nuestro país.
Problems of the constitutional and legal institution of citizenship in the Russian Federation
Authors: Aleshincev Sergej
Published: April 2022

This article discusses and reveals the concepts, principles, problems and significance of the constitutional and legal institution of citizenship, its distinctive features, various scientific opinions on its definition, as well as the characteristic features of citizenship in the form of legal relations in accordance with the legal framework.
Qualification of acts provided for in Article 282.1. of the Criminal Code of the Russian Federation and their differentiation with related elements of crimes
Authors: Akhmedov Damir , Manuilova Evgeniya
Published: April 2022

The article is devoted to the correct qualification and differentiation of socially dangerous criminal acts provided for in Article 282.1 of the Criminal Code of the Russian Federation with related elements of crimes.
Tasks, self-efficacy, and L2 motivational self system in an online emergency EFL speaking class: A mixed-methods study
Authors: Nguyễn Quang Nhật , Phạm Linh Nhật , Nguyễn Hiền Thị Thu
Published: April 2022

Since the World Health Organization initially declared the outbreak of the COVID-19 pandemic, new issues have arisen in English language teaching (ELT). Although task-based language teaching (TBLT) and task-supported language teaching (TSLT) have received significant academic attention and recognition in traditional classroom settings, there is insufficient research on their effects on students’ L2 motivational self system and speaking self-efficacy in an online emergency EFL classroom. Therefore, this mixed-methods study aims at investigating the impacts of TBLT, TSLT, and PPP on the L2 motivational self system and speaking self-efficacy of students at Hanoi University (HANU). After collecting 117 questionnaires from three English-major speaking courses and performing a group interview with 12 students, the researchers examined the quantitative and qualitative data using one-way ANOVA, sentiment analysis, and content analysis. The findings revealed that task-based instruction was more successful than the PPP approach in increasing student speaking self-efficacy and L2 motivational self system in the online emergency EFL speaking classroom. Moreover, teachers should pay attention to five elements related to the application of PPP, TBLT, and TSLT, including the teacher’s role, time allocation, content, group work and peer support, and pre-task/activity preparation, which influence learners’ perceived motivation and speaking self-efficacy
The effects of corpus use on L2 collocation learning
Authors: Satake Yoshiho
Published: April 2022

In data-driven learning (DDL) settings, few studies have examined the specific effects of corpus use on language learning, especially in the study of collocations. This study examined the effects of corpus use on L2 collocation learning. It remains unclear how corpora can contribute to learning collocations and what types of information learners can access and process from these corpora. This study aimed to investigate the effects of corpus use on learning L2 collocations, specifically how information extracted from corpus data assisted learners in retaining and producing collocations. The effects of corpus use were examined by comparison with the effects of dictionary use. Fifty-five intermediate English as a foreign language (EFL) learners from a university in Tokyo looked up verbnoun collocations by consulting either the corpus or the dictionaries, noted related information, and wrote short essays on the topics related to the collocations. Pre- and post-tests were conducted to assess learning. It was found that corpus use promoted a greater collocation output than dictionary use because of the many example sentences and frequency of co-occurrence words. The corpus users focused on word combinations and looked up high-frequency collocations, while the dictionary users focused on meaning, then looked up and memorized the collocations. Findings suggest that teachers need to consider the information that learners access and process when using corpora and the specific effects of corpus use on L2 learning for more effective vocabulary teaching in DDL settings.
Captions and learnability factors in learning grammar from audio-visual input
Authors: Pattemore Anastasia , Muñoz Carmen
Published: April 2022

This study explores the effects of extensive audio-visual input with three captioning modes – unenhanced captions, textually enhanced captions, and no captions – on learning a variety of L2 grammatical constructions and examines the effects of three learnability factors: construction type, frequency, and recency. A total of 112 participants watched ten full-length TV series episodes over a period of five weeks. The study targeted 27 frequently occurring grammatical constructions categorized as fully-schematic, partially-filled, and fully-filled. The design included a pretest, an immediate posttest to measure the effects of recency, and a delayed posttest. The results indicated mixed effects of captioning: textually enhanced captions – a more salient condition – led to immediate learning outcomes while unenhanced captions resulted in higher long-term effects. A limit to the amount of different textually enhanced constructions presented in the input for effective learning is suggested. In general, unenhanced captions appear sufficient for successful grammar construction learning.
Challenges and responses: A complex dynamic systems approach to exploring language teacher agency in a blended classroom
Authors: Qi Grace Yue , Wang Yuping
Published: April 2022

This is a qualitative examination of how a Chinese language teacher responded to challenges and developed her agency in a unique teaching and learning environment, termed as the blended classroom. The uniqueness of this classroom lies in its attendance by two cohorts of students at the same time – a face-toface and an online group. The online group joined the face-to-face group and the teacher via a synchronous online classroom called Blackboard Collaborate. Through analysing data from the teacher’s reflection, face-to-face and email interviews and the recordings of her blended class, this research unfolds a semester-long trajectory of her agency development in the blended classroom. Guided by the Complex Dynamic Systems Theory (CDST), we conclude that teacher agency is a system composed of multi-layers of subsystems and it is a product of the constant interaction amongst these interconnected and interdependent subsystems, with certain subsystems playing a more dominant role than others at a given stage of one’s agency development. This finding led to our proposal of a framework of teacher agency system. This research advances our understanding of teacher agency as a system in the context of online and blended learning.
Statistical analysis of the impact of the e-learning platform Furago on French learners’ listening skills
Authors: Derible Albéric , Wiel Éric
Published: April 2022

The current study focuses on an e-learning platform called Furago designed to provide language instructors with exercises complementing activities already implemented in their classes. Its objective was to assess the impact the use of Furago could have on the listening skills of first-year Japanese university students. Statistical analyses that were used to outline the correlations between the main test variables (i.e., the grades achieved by students on two listening comprehension tests) and several predictor variables pertaining to the platform, such as the score the participants had accumulated or the consistency in which they use it, were all found to be statistically significant, albeit with correlation coefficients that were rather weaker than expected. Despite its users’ slow margin of progression, as evidenced by the linear model conducted during this study, such results confirmed the value of Furago as a means to improve students’ listening skills, especially, it would seem, at the very beginning of foreign language acquisition. Unexpectedly, these results also suggested that the users’ improvement might have more to do with the overall amount of time they put in their study (reflected here by their scores on Furago) than their consistency.
Causes of Infidelity as Expressed by Literate Working-Class Women in Lagos State, Nigeria
Authors: Odebode Aminat Adeola , Adegunju Kabir Adewale
Published: April 2022

The act of infidelity is increasingly high among women and it is causing great concern for stakeholders. This study, therefore, investigated the causes of infidelity as expressed by literate working-class women in Lagos State. The study also examined whether moderating variables such as age and the educational qualification would affect the respondents’ views. A descriptive design was adopted for the study. A total of 300 respondents were drawn from the target population using purposive random sampling and simple random sampling techniques. A researcher-developed questionnaire tagged Causes of Infidelity (CIQ) was used to collect the data. The validity of the questionnaire was established by three experts in the Department of Counsellor Education, University of Ilorin. The reliability of the questionnaire was determined using a split-half method and a correlation coefficient of 0.74 was obtained. The data collected were analyzed using Analysis of Variance (ANOVA) at 0.05 alpha level. Results showed that lack of care and attention, nonchalant attitude of the husband, lack of emotional support, etc. are the causes of infidelity among women. It also showed that there was a significant difference in the causes of infidelity as expressed by literate working-class women based on age but there was no difference based on educational qualification. It was concluded that counsellors should organize seminars for couples to disseminate information on the causes of infidelity among women for possible solutions.
PERAN PENGALAMAN KERJA DALAM MENINGKATKAN KINERJA KARYAWAN: SUATU TINJAUAN TEORITIS DAN EMPIRIS
Authors: Ilham Muhammad
Published: April 2022

Work experience is very necessary in improving employee performance in the company. Employee work experience shows the level of mastery of skills. Employees who have had more years of service will have various kinds of work experience in solving various kinds of problems within the company. It is expected that employees will have good quality resources in improving work performance. The purpose of this study is to describe the role of work experience in improving employee performance scientifically based on the results of the existing literature review. If employees have a lot of work experience, then the abilities possessed by employees will be in accordance with the work given, so that employees have high performance. This employee performance refers to the results of work in completing the work. This role has a positive nature which means the more work experience an employee has, the employee's performance will increase. 
Keywords:
Work Experience; Employee Performance; Performance
Efeitos da estratégia de fluidos durante a ventilação com alta e baixa pressão positiva ao final da expiração no dano pulmonar e renal em modelo de síndrome do desconforto respiratório agudo
Authors: Silva Letícia Almeida da , Maia Ligia de Albuquerque , Rocha Nazareth de Novaes , Rodrigues Gisele Camargo , Silva Mariana Coelho , Pelosi Paolo , Rocco Patricia Rieken Macêdo , Silva Pedro Leme , Felix Nathane Santanna
Published: April 2022

A síndrome do desconforto respiratório agudo (SDRA) é caracterizada por aumento da permeabilidade da membrana alvéolo-capilar (MATTHAY et al., 2012). Desta forma, a infusão de fluidos deve ser control
Stage and symptoms of bipolar disorders
Authors: Gudisa Bereda
Published: April 2022

Bipolar disorder (formerly called manic-depressive illness or manic depression) is a mental disorder that causes unusual shifts in mood, energy, activity levels, concentration, and the ability to carry out day-to-day tasks. During mood swings, there may be features of psychosis (delusions and hallucinations) that are mood-congruent. Although psychotic symptoms are seen only in a minority of patients, they explain the early terminology of manic–depressive psychosis. Stage 1a is defined as mild or non-specific symptoms of mood disorder and intervened as formal mental health literacy; family psychoeducation; substance abuse reduction; cognitive behavioral therapy. Euphoric means the experience of pleasure or excitement and intense feelings of well-being and happiness. Certain natural rewards and social activities, such as aerobic exercise, laughter, listening to or making music, and dancing, can induce a state of euphoria. Racing thoughts are consistent, persistent, often intrusive thoughts that come in rapid succession. There is a direct link between depression and anxiety and racing thoughts. Whereas jumping from topic to topic as in the flight of ideas can be observed by others, ascertainment of racing thoughts requires asking the child whether his or her thoughts seem to be going too fast.
Profiling children with cerebral visual impairment in a tertiary eye care center
Authors: Addisu Worku Teshome , Martha Degefu Worku
Published: April 2022

Background: Cerebral visual impairment (CVI) is a bilateral visual impairment that affects children in all industrialized countries. It has become more common in low-income countries as a result of the increased survival rates of children who suffer from severe neurological conditions during the perinatal period. The purpose of this study was to determine the characteristics of children with CVI in a tertiary children’s eye care center population. Methods: From October 2020 to September 2021, a cross-sectional study was conducted to select all consecutive patients with a diagnosis of cerebral visual impairment aged 6 months to 16 years. On the neurological deficit, information was gathered from the patient’s referral: parental interviews, observations, and direct assessment were used for functional vision characteristics, and an ophthalmic examination was performed for eye findings. The interviewees’ responses were matched to the ten specific behavioral characteristics shared by children with CVI. Cortical visual impairment was diagnosed using three criteria: [the vision loss is not explained by abnormalities found on the eye examination, a neurological medical diagnosis, and the child exhibits one of the unique visual and behavioral characteristics described by Roman Lantz]. A descriptive statistical analysis (frequency, mean, and range) was calculated. Results: Forty children with CVI (1.96% of total children) were seen. The mean age was 2.56 ( 1.98) years. There were 24 (60%) males. On a referral paper of 28, hypoxic-ischemic encephalopathy was the commonest cause mentioned (70.0%). Seizures were the most frequent neurological deficit at presentation. Ophthalmic and neurologic impairments were found in 42.5% of children with CVI. Based on Roman-Lantzy’s three phases of the CVI Range, 90% of children with CVI at the test time had Phase I or Phase II vision. Conclusion: According to the findings of this study, visual impairment is critical in the diagnosis of CVI. The prevalence of CVI as a cause of childhood vision impairment is significant. Hypoxic-ischemic encephalopathy is the most common cause of CVI. All children with CVI have serious neurological issues, and the majority have associated ophthalmic abnormalities.
Outcomes and Associated Factors Among Adult Patients Admitted to Adult Intensive Care Unit, Retrospective Cohort Study
Authors: Bekele Zenebe , Jisha Hunduma , Haile Merga
Published: April 2022

ABSTRACT

Background:

Intensive care unit represent a multidisciplinary and inter-professional specialty dedicated to the total management of patients with acute life threatening condition. Now a day the care is advancing; however, in resource limited country like Ethiopia the care is very poor if any and mortality still high because of numerous reasons.

Objective:

To determine outcome with its associated factors of adult patient admitted to adult intensive care unit (AICU), Ambo University Referral Hospital, and Ambo. Ethiopia.

Method:

After obtaining ethical clearance, a retrospective institution-based cohort study was used. Data were retrieved from all intensive care unit (ICU) admitted patients (from September 2019 to December 2021) using a pre-tested structured questionnaire and the collected data was entered into Epi info and transported to SPSS for analysis. Risk factors and their associations were assessed by logistic regression, bivariate and multivariate logistic regression was used, P value 0.05 on multivariate logistic regression was considered statistically significant.

Result:

Five hundred and fifty patients have been admitted to the intensive care unit. However; only 390 patients had completed data and were analyzed. Majority 203 (52.1%) of participants were men and 155 patients were supplied by the medical service. The overall mortality rate was 46.9%, and significantly associated with Glasgow coma scale < 9 (AOR = 3.7, P value < 0.001), patient with coexisting disease (AOR = 2.2, P value 0.001). AOR = 1.9, P-value 0.011). mechanical ventilation requirements (AOR = 2.6, P-value 0.001) and patients who stayed less than four days in intensive care are more likely to die than patients who stayed longer than four days (AOR = 2.4, P value < 0.001).

Conclusion and recommendation:

The overall death rate in the intensive care unit is high and patient with low Glasgow coma scale, coexisting disease, need of mechanical ventilation short duration of stay are associated with mortality in intensive care unit. Therefore; we recommend the improvement of acute intensive care through the expansion of care, the provision of emergency equipment, drugs and human resources from different disciplines.

Highlights
Visão da Igreja a partir da Periferia
Authors: Casaldáliga Pedro
Published: April 2022

Leonardo Boff pediu-me uma colaboração para a REB. Na impossibilidade de me negar, porque a amizade e a gratidão são dívidas, e na impossibilidade também de escrever agora um texto original, ofereci a Leonardo um pequeno extrato da conversa que tivemos aqui em casa, no Mato Grosso, o pastoralista amigo, irmão, Teófilo Cabestrero e eu. Ele publicou essa conversa gravada, num livro: Diálogos en Mato Grosso con Pedro Casaldáliga, Ediciones Sígueme, 1978, Apartado 332, Salamanca, Espanha. E agora eu entrego aos leitores amigos da REB esse texto pedido.
Safety-critical Policy Iteration Algorithm for Control under Model Uncertainty
Authors: Moshtaghi Yazdani Navid , Kardehi Moghaddam Reihaneh , Olyaei Mohammad Hasan
Published: April 2022

Safety is an important aim in designing safe-critical systems. To design such systems, many policy iterative algorithms are introduced to find safe optimal controllers. Due to the fact that in most practical systems, finding accurate information from the system is rather impossible, a new online training method is presented in this paper to perform an iterative reinforcement learning based algorithm using real data instead of identifying system dynamics. Also, in this paper the impact of model uncertainty is examined on control Lyapunov functions (CLF) and control barrier functions (CBF) dynamic limitations. The Sum of Square program is used to iteratively find an optimal safe control solution. The simulation results which are applied on a quarter car model show the efficiency of the proposed method in the fields of optimality and robustness.
A concise review on method development and validation parameters
Authors: Shipra Thapar  , Anshul Chawla  , Girish Kumar Gupta
Published: April 2022

Method development is a broad term. In both quantitative and qualitative analysis developing a new method either for estimation of quantity of substance or to check the presence of the required component is a necessitate step. Validation means to establish the characteristics parameters of the method. It also helps by revealing the limitations and their extent of the method. Both terms are essential to create and then establish for any drug component so that it can be used in any pharmaceutical industry for its benefit. Generally, the guidelines are followed as laid by ICH and USP which are followed worldwide. In this review article, some parts have been explained in reference to the subject quoted above.
Law Enforcement on The Case Of Setting The Score in Soccer Competition (Comparative Study in Indonesia, Netherland, and Italy)
Authors: Waditra Vitrona Adhe , Susanti Rahtami , Setiawan Bayu
Published: April 2022

Setting scores in football matches often occur whether coaches, players, or match officials do it. Several countries such as Italy, the Netherlands, and Indonesia already have regulations containing legal sanctions for these practices. This study used a normative juridical method obtained through a literature review, then analyzed qualitatively normative. This study aims to determine the law enforcement of scoring cases in soccer matches in Indonesia, the Netherlands, and Italy. The results showed that scoring arrangements in Indonesia could be acted upon under Law No. 20 of 2001 on amendments to Law No. 31 of 1999 concerning the Eradication of Corruption, while in the Netherlands, it used Wetboek van Strafrecht (Criminal Code) article 326, and in Italy regulated in Legge 13 dicembre 1989 n.401: truffa sportiva.Keywords: Score Setting, Football.
Exploring Dimensions of Spiritual Faithfulness in Church Ministry: A Narrative Study of Senior Pastor’s Ministry
Authors: Irawan Dadang , Pramono Rudy , Hermawati Oki , Santosa Erwin , Djap Wylen
Published: April 2022

Faithfulness is often a virtue that sustains a mission of service. This study aimed to tell the experience one of the important actors (participants), a pastor. What are the dimensions that can build a faithful construction, especially in church services based on the experiences of participants. In a religious context, faithfulness has a different dimension, namely a transcendental dimension that does not stand alone, but is also influenced by a horizontal perspective which can be explained by the theory of stewardship. When stewardship is understood horizontally, the highest measurement of a relationship tends to be welfare and harmony. It gets reinforced by the vertical dimension where God becomes the authority of truth and becomes the reason to keep serving, especially serving faithfully. This study tries to frame the story about the phenomenon of faithfulness dimension in church ministry with a narrative approach. This study seeks to show how life of a pastor who uses faithfulness as the main pillar of his ministry.
Makna Belas Kasih Allah dalam Hidup Manusia Menurut Henri J. M. Nouwen
Authors: Adon Mathias Jebaru , Firmanto Antonius Denny
Published: April 2022

Abstract. This research focused on the meaning and significance of compassion in human life. In daily life compassion is often understood as being sympatic to the sufferings of the other. More or less described as a sentiment feeling. Yet compassion is more than sentimental attitudes and feelings. This research was conducted using Henri J. M. Nouwen thoughts on God's compassion. Through this research, it was understood that compassion means sharing deeply with the suffering of others, namely: crying with those who shed tears, being vulnerable with those who are fragile and laughing with those who laugh. However, this cannot be done individually as individuals but in togetherness as a community. In this community of love, our hearts and ears are more sensitive to suffering.Abstrak. Fokus penelitian ini adalah pada arti dan makna belas kasih dalam hidup manusia. Dalam hidup sehari-hari belas kasih sering dimengerti sebagai bersikap ramah terhadap penderitaan dunia. Kurang lebih digambarkan sebagai perasaan belas kasihan. Padahal belas kasih lebih dari sikap dan perasaan sentimental. Penelitian ini dilakukan dengan menggunakan pemikiran Henri J. M. Nouwen Belas tentang belas kasih Allah. Melalui penelitian ini diperoleh makna bahwa belas kasih lebih berarti compassion, ikut merasakan secara mendalam dengan penderitaan sesama, yakni: menangis bersama mereka yang mencucurkan air mata, ringkih bersama mereka yang ringkih dan tertawa mereka yang tertawa. Namun hal tersebut tidak dapat dilakukan secara sendiri-sendiri sebagai individu-individu tetapi dalam kebersamaan sebagai komunitas. Dalam komunitas kasih ini, hati dan telinga kita lebih peka dengan penderitaan.
THE EFFECT OF KERSEN (Muntingia calabura L.) LEAF EXTRACT NANOGEL ON STOMATITIS
Authors: Ariyati Retno Pratiwi  , Muyasaroh Linda Risalatul
Published: April 2022

Latar belakang: Stomatitis aftosa rekuren (SAR) menjadi penyakit mulut terbesar ketiga di Indonesia dengan prevalensi 8%, mencapai 5%-60% dari populasi dunia. Umumnya, pengobatan SAR menggunakan topikal steroid sehingga penggunaan dalam jangka panjang dan atau berulang memiliki efek samping seperti adrenal suppression, kandidiasis, burning sensation, atrofi mukosa, dan xerostomia. Saat ini, esktrak tanaman sedang dikembangkan sebagai obat herbal seperti daun kersen (Muntingia calabura L.). Ekstrak daun kersen mengandung flavonoid yang dapat mempengaruhi jumlah makrofag dan stimulasi kolagen pada proses penyembuhan SAR. Penerapan teknologi nanopartikel dengan sediaan topikal gel bertujuan untuk memaksimalkan kerja flavonoid. Tujuan: mengetahui pengaruh nanogel ekstrak daun kersen terhadap penurunan jumlah makrofag dan stimulasi kolagen pada stomatitis. Metode: Penelitian ini menggunakan pendekatan Literature Review. Pencarian jurnal menggunakan metode PRISMA dengan database ScienceDirect, Pubmed, Scielo, NCBI, Researchgate, dan Google Scholar menggunakan kata kunci pencarian yaitu: “Muntingia calabura L. leaves extract”, “nanogel”, “flavonoid”, “quercetin”, “fisetin”, “macrophage”, “collagen”, “soft tissue healing process” dan “recurrent aphthous stomatitis” sebanyak 1107 artikel. Hasil seleksi literatur ditemukan 22 artikel. Hasil penelitian: Flavonoid dalam ekstrak daun kersen dapat menurunkan jumlah makrofag dan meningkatkan stimulasi kolagen. Proses mekanisme kerja dimulai dengan menghambat produksi sitokin proinflamasi, menghambat migrasi dan adhesi makrofag, menstimulasi produksi growth factor oleh makrofag untuk sintesis kolagen, dan menurunkan kolagenase. Sediaan nanogel dapat meningkatkan waktu retensi dan penetrasi obat. Kesimpulan: Ekstrak daun kersen berbasis nanogel mempunyai pengaruh terhadap penurunan jumlah makrofag dan stimulasi kolagen pada SAR minor.
HALAL AND THAYYIB FOOD IN ISLAMIC SHARIA PERSPECTIVE
Authors: Tsani Ali Farkhan , Susilo Hadi , Suyamto Suyamto , Setiawan Usman , Sudanto Sudanto
Published: April 2022

Consumption of halal and thayyib food  will make it easier for someone to do good deeds, this is mentioned in the Qur'an Surah Al Maidah verse 88. Halal is goods that are not haram, consuming them is not prohibited by religion. At least, the prohibition can be divided into two aspects. First, haram in essence or materially has been declared haram by the Shari'a, such as pigs, carrion, and blood. Second, haram is not in essence, but can be from the way of buying, obtaining, or processing the goods. Thayyib means something that is holy, not unclean, and not disgusting which is not liked by the soul. Whoever eats unlawful food, whether he wants it or not, his limbs will tend to sin, whether he realizes it or not. Whoever eats halal food, surely his limbs will obey and be given God’s guidance to do good.
NARRATIVE REVIEW: STUDY OF MICROBIAL-BASED TIPPING POINTS AS HALAL FOOD PRODUCTS
Authors: Fathurrohim Muhammad Faizal
Published: April 2022

The majority of Indonesia's population is Muslim. Halal product testing needs to be tested for its tipping point, especially those made from microbes. Microbial products have been determined by the critical point procedure. The critical point of the idolatry of a food product is a stage of food production where a product allows it to become haram status. Identification of testing the critical point of a microbial product can go through several stages, namely food sources, microbial media, and processing procedures. Based on MUI, halal products are produced from animals or materials that are included in the halal category. The use of microbes in producing products is a rapid step in the food production process. Things that need to be considered in its processing include materials and growth media.
ANALISA STRATEGI PENINGKATAN SERTIFIKASI HALAL SEKTOR KULINER DI BANGKA SELATAN
Authors: Aprilia Sifa , Priantina Anita
Published: April 2022

This study discusses priority problems, priority solutions, and priority strategies in increasing the number of halal certifications in the culinary sector in South Bangka Regency. The research method uses the Analytical Network Process (ANP). Based on the research results, the priority problem faced by South Bangka MSME actors is the lack of information dissemination and socialization related to halal certification. The priority solution that can be offered in increasing the number of halal certifications in South Bangka is to hold training related to halal certification, starting from filing to issuing halal certification. And the priority strategy implemented in increasing the number of halal certifications in South Bangka is to increase information, education, and socialization related to halal certification to business actors.
Evaluation of radar image processing efficiency based on intelligent analysis of processes
Authors: Zhyrnov V. , Solonskaya S. , Shubin I.
Published: April 2022

The paper presents results of development of the method and experimental studies of the system for automatic detection of radar signals of aerial objects and their recognition with the processing of real records in surveillance radars. The relevance of this work consists in creation of algorithms for automatic information processing to ensure effective detection of useful signals due to accumulation of signal (energy) and semantic information. The method is based on the definition of semantic components at the stage of formation and analysis of the symbolic model of signals from point and extended air objects. Signal information is described by the predicate function of process knowledge of the formation and analysis of a symbolic model of a burst of impulse signals from point-like mobile aircraft such as an airplane, a helicopter, a UAV, and from extended atmospheric formations such as angel-echoes, clouds. As a result of semantic analysis of symbolic images of signal marks, classification distinctive features of air objects were obtained. The semantic components of the decision-making algorithm, similar to the decision-making algorithms used by the operator, have been investigated. In the developed algorithm, signal information is described by a predicate function on the set of signal mark pulse amplitudes that have exceeded a certain threshold value. Recognizing of aerial objects is carried out by solving the developed equations of predicate operations. The verification of the developed method was carried out on real data obtained on a survey radar of the centimeter range (pulse duration was 1 μs, probing frequency wass 365 Hz, survey period was 10 s). Based on these data, the types of characteristic marks of radar signals are modeled. According to the results of the experiments, they were all correctly identified.
Specific features of immunity control of survey radar under its suppression by active interference and interfering information effects
Authors: Kantsedal V.M. , Mogyla А.A.
Published: April 2022

The features of goal-setting control while ensuring the information stability of the sounding modes of a surveillance radar when it is suppressed by active interference and interfering information influences are considered. Overcoming the complexity of goal-setting processes, the validity and efficiency of decision-making with a shortage of time for its adoption is associated with insuring the consistency of goal-setting processes, increasing the levels of their intellectualization and formalization. This will contribute to imparting the desired properties, synthesized during the conflict, to the multipurpose strategies and the situational law of the control of the REP processes and the coordination of actions.
An increase in the level of intellectualization of goal-setting processes is ensured by:
- decomposition of the general goal-setting problem into separate, simpler subtasks with effective solutions, implemented in the corresponding subsystems of the ACSstab (or basic associations of its functional elements) at stages of information support, preparation, adoption and implementation of the decision  at the stages of hierarchical levels of management;
- cognitive analysis of goals and reflexive synthesis of goal-setting processes using the capabilities of a specialized intelligent decision support system to enhance the creative-reflexive abilities of the subject of management and increase the level of his professional competencies;
- combining the universality of the stages of rational management of the synthesis of the strategy for managing the REP processes with the specifics of conflict situations, subjectivity, cognition and reflexivity nature of intellectual control.
Methods and means for partial formalization of goal-setting processes are presented, when the structuring of the main goal is carried out taking into account belonging to the strategies of internal and external control of the REP, the decomposition of the two-sided dynamic model of the conflict between the systems of the RES complex and the radar, the hierarchy of management levels, various approaches applied to goal-setting in a crisis management, as well as methods of justifying goals, resource costs and control of achieving the goals.
These features can significantly reduce the degree of subjectivity of management for goal-setting and achieve their validity, completeness, consistency.
Hegemoni Elit-Elit Lokal Donggo dalam Membangun Gerakan Sosial di Bima Tahun 1972
Authors: Subari Subari , Anwar Anwar
Published: April 2022

Abstrak, Penelitian ini menggunakan metode penelitian sejarah (history research). Langkah-langkah dalam penelitian sejarah adalah pemilihan topik, pengumpulan sumber (heuristic), kritik (verifikasi), analisis dan sintesis (Interpretasi), dan penulisan (historiografi). Hasil penelitian menjelaskan bahwa gerakan social yang dilakukan oleh elit-elit local bersama masyaraka tradisional Donggo menuntut ketidak adilan kepada rezim pemerintahan Kabupaten Bima. Gerakan social ini dilakukan dalam bentuk perlawanan terhadap perlakuan pemerintahan Soeharmadji sebagai representasi Orde Baru dengan menanamkan system politik tataliter dan intimidasi terhadap warga Negara. Gerakan social ditandai dengan danya kesadaran kolektif oleh tokoh local untuk hidup dalam kehidupan yang layak dan keadilan yang sama di bumi (Maja labo dahu) semboyang daerah Kabupaten Bima. Gerakan protes yang dilakukan oleh arus bawah dituding sebagai agenda makar dengan melawan pemerintah yang sah. Perlawanan itu menjadi sebuah langkah massif bagi rezim militer untuk melakukan tindakan represif terhadap tokoh-tokoh penggerak dan masyarakat yang tidak berdosa.

Kata Kunci: Hegemoni, Elit Lokal, Gerakan Sosial
THE MANAGEMENT OF BANGSRING UNDERWATER AS CONSERVATION - BASED ECOTOURISM FOR INTERNATIONAL TOURISM DESTINATION
Authors:   Universitas Negeri Malang, Faculty of Social Science, Geography Department, Malang, Indonesia, SUMARMI Sumarmi , ENSIYAWATIN Aminatus Zuhro ,   Universitas Negeri Malang, Faculty of Social Science, Geography Department, Malang, Indonesia, ASTINA I Komang ,   Universitas Negeri Malang, Faculty of Social Science, Geography Department, Malang, Indonesia, KURNIAWATI Elya ,   Universitas Negeri Malang, Faculty of Social Science, Sociology Department, Malang, Indonesia, SHRESTHA Rajendra P. ,   School of Environment, Resources and Development, Asian Institute of Technology, Pathumtani, Thailand
Published: April 2022

Bangsring Underwater site has high potential of ecotourism attraction for international tourists. The purpose of this study was to determine 1) the potential of Bangsring Underwater ecotourism based on attractions, accessibility, amenities, and 2) Bangsring underwater management as conservation-based ecotourism for the international tourist destination. The research design used qualitative descriptive methods. The primary data were obtained from observations and focus group discussions (FGD) with related parties, while secondary data obtained from government agencies, institutions, and communities in the Banyuwangi Regency. The data were analyzed using qualitative descriptive analysis. The results showed that Bangsring underwater has high potential in attractions, accessibility, amenities, and 2) the management of Bangsring underwater can make the place an ecotourism destination for international tourists. Furthermore, it is recommended that the alternative policies are needed to create conservation-based ecotourism for international tourist destinations.
Rate Setting for Labour Costs Related to Pharmacovigilance System Inspections
Authors: Abdrakhmanov M. , Alyautdin R. N. , Krasheninnikov A. E. , Romanov B. K.
Published: April 2022

The inspection of pharmacovigilance systems is regulated by the Good Pharmacovigilance Practices (GVP) and local laws and regulations. Inspections may be carried out by audit teams of competent authorities as part of regulatory activities or business agreements. So far, there have been no studies dealing with rate setting for competent authorities labour costs in connection with onsite or documentary inspections of pharmacovigilance systems.

The aim of the study was to develop scientifically valid rate setting criteria for labour costs related to onsite or documentary inspections of pharmacovigilance systems.

Materials and methods: the assessment of labour costs was carried out by surveying experts of two Eurasian Economic Union (EAEU) countries who have experience in preparing and conducting evaluation and inspection of pharmacovigilance systems. The calculation of the experts’ time costs was performed automatically using the CrocoTime software. The expected workload for experts in 2022 was estimated based on the reports over the last 5 years (2016–2020) containing information on the number of foreign marketing authorisations, and the number of medicines under development according to national registers of medicinal products of the EAEU member states.

Results: the study calculated the average expert labour costs and estimated workload for the EAEU competent authorities in 2022. It was demonstrated that the average labour costs are comparable in EAEU member states, however, estimated amount of labour may change (both increase or decrease).

Conclusions: further study of rate setting for labour costs related to pharmacovigilance documentary inspections and study of competent authorities staffing could be performed by a dedicated division, e.g. of the Eurasian Academy of Good Practices. A constructive discussion of approaches to the improvement of control over pharmacovigilance systems will increase availability of efficacious and safe medicines of assured quality for the population and help pharmaceutical companies and regulatory authorities manage financial and reputational risks.
Ivermectin: Evaluation of Efficacy and Safety in COVID-19
Authors: Shubnikova E. V. , Susekova N. A. , Bukatina T. M. , Galenko M. S. , Druzhinina A. A.
Published: April 2022

The search for an effective and safe COVID-19 therapy involves, among other things, assessment of efficacy of medicines already used for the treatment of other diseases, and having potential antiviral activity against SARS-CoV-2. The relevance of the presented study stems from ambiguous data on the off-label use of the antiparasitic medicine ivermectin for the treatment of COVID-19 patients. The aim of the study was to analyse ivermectin efficacy and safety for COVID-19 treatment, as reflected in the scientific literature. Ivermectin, an antiparasitic medicine from the group of macrocyclic lactones produced byStreptomyces avermitilis, stimulates release of the inhibitory neurotransmitter gamma-aminobutyric acid, which leads to impaired transmission of nerve impulses, paralysis and death of parasites. The results of preclinical studies show ivermectin’s inhibitory activity against a number of RNA and DNA viruses, including SARS-CoV-2. The results of ivermectin clinical studies are ambiguous: a number of studies demonstrated a positive effect on the condition of COVID-19 patients, however, there is currently no convincing evidence of the validity and efficacy of ivermectin use for the prevention and treatment of COVID-19 patients. The safety profile of ivermectin is relatively favourable. Large randomised controlled trials are needed to fully assess the feasibility of using ivermectin in COVID-19.
Genetic Risk Factors for Adverse Drug Reactions
Authors: Sychev D. A. , Chernyaeva M. S. , Ostroumova O. D.
Published: April 2022

The use of medicines may in some cases be associated with the development of drug-induced diseases (DIDs) аnd other adverse drug reactions (ADRs), which leads to an increase in morbidity/mortality rates, and/or symptoms forcing a patient to seek medical attention or resulting in hospitalisation. ADRs may develop due to changes in a patient’s genotype, which entail an inadequate pharmacological response. The aim of the study was to analyse and summarise literature data on genetic risk factors that cause DIDs аnd other ADRs. It was shown that the polymorphism of genes encoding enzymes of drug metabolism (CYP, UGT, NAT, TPMT, EPHX, GST, etc.) or carriers (transporters) of drugs (P-gp, BCRP, MRP, OATP, OCT, etc.) can change the pharmacokinetics of drugs, affecting their activity. Polymorphism ofRYR1, CACNA1S, MT-RNR1, VKORC1, and other genes encoding receptors targeted by drugs, and human leukocyte antigen (HLA) gene, may affect drug pharmacodynamics by modifying drug targets or changing the sensitivity of biological pathways to pharmacological effects of medicines. Changes in drug pharmacokinetics and pharmacodynamics may cause DIDs аnd other ADRs. The use of pharmacogenetic tests will allow a personalised approach to patients’ treatment and prevention or timely detection of potential ADRs during therapy. Before prescribing some medicines, clinicians should use recommendations on their dosing based on pharmacogenetic tests, which are posted on the official websites of Pharmacogenomics Research Network (PGRN), Pharmacogenomics Knowledgebase (PharmGKB), and Clinical Pharmacogenetics Implementation Consortium (CPIC). The results of ongoing clinical studies on the effect of gene polymorphism on drug safety will soon allow for higher personalisation of the choice of pharmacotherapy and prevention of many ADRs, including DIDs.
Changes in Post-COVID Syndrome Manifestations and Bulbar Conjunctival Angioscopy Results in a Patient Undergoing Treatment after Mild COVID-19
Authors: Arkhipov V. V. , Kheilo T. S. , Gladysheva E. G. , Danilogorskaya Yu. A. , Dzhavatkhanova M. R. , Snytko S. V. , Samorukova I. V. , Zhuravleva M. V.
Published: April 2022

Microcirculation dysfunction plays a significant role in the development of post-COVID syndrome caused by SARS-CoV-2. However, there have been no studies on changes in microcirculation parameters during pharmacotherapy in patients with post-COVID syndrome. To date, there are no consensus recommendations for the treatment of post-COVID syndrome in the Russian Federation.

The aim of the study was to analyse the pattern of clinical manifestations of post-COVID syndrome and bulbar conjunctival angioscopy (BCA) results in a young patient undergoing treatment after mild COVID-19.

Materials and methods: analysis of the clinical case of a patient who was followed up at the Therapeutic Ophthalmology Centre between February and September 2021. BCA was performed in a patient with post-COVID syndrome to compare quantitative and qualitative microcirculation parameters before and after the treatment.

Results: the paper summarises clinical observation data on a 23-year-old female patient with post-COVID syndrome with mainly neuropsychiatric manifestations and a microcirculation dysfunction as determined by BCA. The patient received pharmacotherapy with meldonium, ethylmethylhydroxypyridine succinate, and meglumine sodium succinate.

Conclusions: the prescribed pharmacotherapy led to a significant improvement in the patient’s condition (regression in neuropsychiatric symptoms) with simultaneous improvement of morphological and functional parameters assessed by BCA, which indicates an improvement in microcirculation processes and supports their role in post-COVID syndrome development. The obtained data suggest that the clinical picture of post-COVID syndrome is directly related to the severity of microcirculation dysfunction in various organs and tissues, and that BCA can be used for diagnosis and assessment of the syndrome’s severity, as well as for assessment of the treatment’s efficacy and safety.