bluuebunny/crossref_metadata_2025 huggingface dataset:
Progressive Multifocal Leukoencephalopathy (PML) in a Patient with Classic Hodgkin’s Lymphoma Post-Bone Marrow Transplant: A Case Report
Authors: Rehman Ibad ur , Ali Zafar , Rasheed Sana , Ullah Irfan , Irfan Muhammad , Nashwan Abdulqadir
Published: October 2022

A 29-year-old male patient who underwent an autologous bone marrow
transplant. He was initially diagnosed with Hodgkin’s lymphoma and
treated with 12 cycles of chemotherapy. Three months later, he presented
with intermittent fever and underwent an MRI scan and a biopsy.
Eventually, he was diagnosed with progressive multifocal
leukoencephalopathy.
The Impact of Blockchain Technology Adoption Announcements on Firm’s Market Value
Authors: Jeong Anna Y. , Lim Jee-Hae
Published: October 2022

Despite the growing interest in blockchain (BC) technology, recent research shows mixed perceptions due to its risks and returns. We utilize event study methodology to examine overall market reactions and to delineate how specific contexts associated with BC technology influence the market reactions. Using 149 BC technology adoptions announced between January 2015 and December 2019, we find positive abnormal returns, reflecting investors’ optimistic perception toward BC technology adoption. Specifically, we find that abnormal returns from BC technology are higher when used in a transformative strategic role and offered by leading vendors, suggesting that investors view this adoption as a value-enhancing activity. Our results are robust to the use of an alternative sample and different methods of measuring variables. Overall, our study provides insights for academics and practitioners to better understand the market value of BC technology adoptions.

Data Availability: Data are available from the public sources cited in the text.
Clinical Clearance Following Improvement of Histologic Subtype of Basal Cell Carcinoma with Sonidegib
Authors: Leow Liang Joo , Howard Vicki
Published: October 2022

Abstract is missing (Short communication)
Selective laser crystallization and amorphization in polymer fibers
Authors: Wheeler Francesca , Tyrer John R. , Jones Lewis C. R.
Published: October 2022

Textile finishing is a huge industry for modification of textile surface properties to align with the desired end use spanning medical, engineering, and apparel applications. Laser-induced polymer morphology modification has been studied by researchers, with evidence suggesting a correlation between laser fluence and crystallinity. However, a lack of data has resulted in the mechanism for change remaining unknown. This paper aims to identify the mechanism of initial Young’s modulus control in polyethylene terephthalate (PET) monofilament yarn and explain the relationship between Young’s modulus and the degree of crystallinity using Takayanagi’s model. PET monofilament yarns were treated using a CO2 infrared laser at a 10.6 μm wavelength at fluences up to 0.086 J/mm2. Young’s modulus data obtained from stress-strain curves at 0.2% strain and fraction crystallinities obtained from differential scanning calorimetry were compared with Takayanagi’s series model. Laser surface treatment within a fluence range up to 0.087 J/mm2 on PET resulted in stable Young’s modulus values. A 3.5% reduction in Young’s modulus of PET was seen with a 6.1% reduction in crystallinity, which was in good agreement with Takayanagi’s series model. Lasers offer rapid material processing capable of increasing or decreasing fractional crystallinity selectively along the fiber where desired. Selective amorphization increases chemical absorption, allowing increased surface finishing uptake at milder processing conditions, whereas increasing fractional crystallinity imparts fiber strength. The relationship between fiber crystallinity and Young’s modulus for PET can be described by Takayanagi’s model, allowing a prediction of material properties, which can be extended from fibers to all thin-film polymers.
Laser microdrilling of CFRP with a nanosecond-pulsed high-power laser
Authors: Staehr R. , Wippo V. , Jaeschke P. , Kaierle S.
Published: October 2022

The global demand for air travel and air transport is expected to further increase in the next couple of years, and so the environmental protection will also increasingly come into focus again. In the aviation sector, this means not only saving fuel and reducing emissions but also reducing the noise pollution caused by aircrafts. For this purpose, sound-absorbing acoustic liners are used, which consist of a sandwich structure with one perforated skin layer. To reduce weight, these outer layers are often made of carbon fiber-reinforced plastic (CFRP). For manufacturing these CFRP skin layers, laser drilling offers specific benefits, but when it comes to industrial applications, further process improvements are necessary. Although laser microdrilling is a well-known process in laser materials’ processing, it has not yet been sufficiently investigated for the processing of carbon fiber-reinforced plastics. This study investigates the quality and efficiency of laser microdrilling with a 1.5 kW nanosecond-pulsed high-power laser for percussion drilling and helical drilling of thin CFRP laminates. The efficiency was evaluated in terms of drilling depth, the amount of energy required to remove a specific volume of material, and the time required to remove a specific volume of the material. The quality evaluation focused on the heat-affected zone and the hole taper. The efficiency and quality results were set in relation to higher-level parameters such as energy fluence in the laser spot, pulse overlap, or total energy applied. This facilitates future transferability to similar laser processes that may use laser machines and system technology with deviating specifications.
„Mistrzowie koziobrodzi” — krawcy i ich cech w Krakowie XIV–XV wieku
Authors: Starzyński Marcin
Published: October 2022

Cech krawców krakowskich nie był dotąd przedmiotem osobnego opracowania. Wykorzystując wzmianki z najstarszych ksiąg miejskich, wilkierz z 1392 r. oraz zachowany statut z 1434 r. Autor przedstawił genezę tej organizacji rzemieślniczej, powstanie której datował na czasy panowania Kazimierza Wielkiego, oraz geografię rozmieszczenia pracowni w przestrzeni miasta. Uzupełniając wywód o źródła ikonograficzne, materialne (XV-wieczny notatnik krawiecki) i głównie nowożytną literaturę ludową wyjaśnił, dlaczego krawca przedstawiano z „kozią” brodą oraz jakie negatywne cechy przypisywano przedstawicielom tego rzemiosła.
Naczynia ceramiczne z drugiej połowy XV–pierwszej połowy XVI wieku z badań wykopaliskowych na Polskim Rynku w Kamieńcu Podolskim
Authors: Nechytailo Pavlo
Published: October 2022

Podczas badań wykopaliskowych przeprowadzonych przy placu Polski Rynek w Kamieńcu Podolskim odkryto relikty spalonego budynku z najstarszej fazy funkcjonowaniamiasta. W wypełnisku tego obiektu odkryto zbiór fragmentów naczyń ceramicznychz XV–XVI w. stanowiących zespół reprezentatywny dla wytwórczości garncarskiej, wykorzystującej zunifikowane wzorce technologiczne, typologiczne i stylistyczne powszechnie reprezentowane na terenie Środkowej Europy.
Impact of needle type on substitution volume during online hemodiafiltration: plastic cannulae versus metal needles
Authors: Cho AJin , Park Hayne Cho , Kim Do Hyoung , Choi Han Byul , Song Gi Hyun , Kim Hyunsuk , Kim Seok-hyung , Choi Gwangho , Kim Jwa-Kyung , Song Young Rim , Yoon Jong-Woo , Lee Young-Ki
Published: October 2022

Background: Plastic cannulae have attracted increasing interest as an alternative to traditional metal needles with the aim of reducingcannulation-related complications. We investigated whether the substitution volumes during hemodiafiltration differ using thesetwo types of needles in dialysis patients.Methods: An intervention study involving 26 hemodialysis patients was conducted in Korea between March and September in 2021.Patients first received online hemodiafiltration using traditional metal needles, and thereafter plastic cannulae were used in a stepwiseprotocol. Repeated-measures design and linear mixed-effect models were used to compare substitution volumes between thetwo needle types with the same inner diameter.Results: The mean patient age was 62.7 years, and their mean dialysis vintage was 95.2 months. Most patients (92.3%) had an arteriovenousfistula as the vascular access. The substitution volume increased as blood flow and needle size increased for both plasticcannulae and metal needles. The substitution volume was significantly higher with 17-gauge (G) plastic cannulae than with 16-G metalneedles at blood flow rates of 280, 300, and 330 mL/min. Similar results were obtained for 15-G metal needles and 16-G plasticcannulae at a blood flow rate of 330 mL/min. However, the patient ratings of pain on a visual analogue scale were higher for plasticcannulae.Conclusion: Higher substitution volumes were obtained at the same prescribed blood flow rate with plastic cannulae than with metalneedles during online hemodiafiltration. Plastic cannulae are an option for achieving high-volume hemodiafiltration for patients withlow blood flow rates.
Serum calcification propensity and its association with biochemical parameters and bone mineral density in hemodialysis patients
Authors: Kim Hyunsook , Kim Ae Jin , Ro Han , Chang Jae Hyun , Lee Hyun Hee , Chung Wookyung , Jung Ji Yong
Published: October 2022

Background: T50 is a novel serum-based marker that assesses the propensity for calcification in serum. A shorter T50 indicates a greater propensity to calcify and has been associated with cardiovascular disease and mortality among patients with chronic kidney disease. The factors associated with T50 and the correlation between T50 and bone mineral density (BMD) are unknown in hemodialysis (HD) patients. Methods: This cross-sectional study included 184 patients undergoing HD. Individuals were grouped into tertiles of T50 to compare the demographic and disease indicators of the tertiles. Linear regression was used to evaluate the association between T50 and hip and spinal BMD in a multivariate model. Results: Mineral and inflammatory parameters, including serum phosphate (r = –0.156, p = 0.04), albumin (r = 0.289, p < 0.001), and high-sensitivity C-reactive protein (r = –0.224, p = 0.003) levels, were associated with T50. We found a weak association between T50 and BMD in the total hip area in the unadjusted model (β = 0.030, p = 0.04) but did not find a statistically significant association with the total hip (β = 0.017, p = 0.12), femoral neck (β = –0.001, p = 0.96), or spinal BMD (β = 0.019, p = 0.33) in multivariable-adjusted models. Conclusion: T50 was moderately associated with mineral and inflammatory parameters but did not conclusively establish an association with BMD in HD patients. Broad-scale future studies should determine whether T50 can provide insights into BMD beyond traditional risk factors in this population.
Recent innovations in renal replacement technology and potential applications to transplantation and dialysis patients: a review of current methods
Authors: Dominy Calista L , Shamsian Ethan B. , Okhawere Kennedy E. , Korn Talia G. , Meilika Kirolos , Badani Ketan
Published: October 2022

The current standard of care for patients with end-stage renal disease (ERSD) is a kidney transplant or dialysis when a donor organ isnot available. The growing gap between patients who require a kidney transplant and the availability of donor organs as well as thenegative effects of long-term dialysis, such as infection, limited mobility, and risk of cancer development, drive the impetus to developalternative renal replacement technology. The goal of this review is to assess the potential of two of the most recent innovations inkidney transplant technology—the implantable bioartificial kidney (BAK) and kidney regeneration technology—in addressing the aforementionedproblems related to kidney replacement for patients with ERSD. Both innovations are fully implantable, autologous, personalizedwith patient cells, and can replace all aspects of kidney function. Not only do these new innovations have the potential toimprove the possibility of transplantation for more patients, they also have potential to improve the outcome of transplantation or dialysis-related renal cancer diagnosis. A major limitation of the current technology is that both implantable BAK and kidney regenerationtechnology are still in preclinical stages, and thus their potential effects cannot be comprehensively generalized to human patients.
Healthy aging and chronic kidney disease
Authors: Merchant Reshma Aziz , Vathsala Anantharaman
Published: October 2022

The world population is aging and the prevalence of noncommunicable diseases such as diabetes, hypertension, and chronic kidney disease (CKD) will increase significantly. With advances in medical treatment and public health, the human lifespan continues to outpace the health span in such a way that the last decade of life is generally spent in poor health. In 2015, the World Health Organization defined healthy aging as ‘the process of developing and maintaining the functional ability that enables wellbeing in older age.’ CKD is increasingly being recognized as a model of accelerated aging and is associated with physical performance decline, cognitive decline, falls and fractures, poor quality of life, loss of appetite, and inflammation. Frailty and dementia are the final pathways and key determinants of disability and mortality independent of underlying disease. CKD, dementia, and frailty share a triangular relationship with synergistic actions and have common risk factors wherein CKD accelerates frailty and dementia through mechanisms such as uremic toxicity, metabolic acidosis and derangements, anorexia and malnutrition, dialysis-related hemodynamic instability, and sleep disturbance. Frailty accelerates glomerular filtration decline as well as dialysis induction in CKD and more than doubles the mortality risk. Anorexia is one of the major causes of protein-energy malnutrition, which is also prevalent in the aging population and warrants screening. Healthcare systems across the world need to have a system in place for the prevention of CKD amongst high-risk older adults, focusing on screening for poor prognostic factors amongst patients with CKD such as frailty, poor appetite, and cognitive impairment and providing necessary person-centered interventions to reverse underlying factors that may contribute to poor outcomes.
Análise de uma intervenção por meio de jogos em crianças com história de insucesso escolar
Authors: Pinheiro Silvia Nara Siqueira , Frison Lourdes Maria Bragagnolo , Migueis Marlene da Rocha
Published: October 2022

O insucesso escolar no ensino fundamental brasileiro tem sido objeto de pesquisas e é motivo de preocupação de todos os profissionais que trabalham na área. Neste sentido, o artigo apresenta resultados da pesquisa que teve como objetivo investigar se as intervenções mediadas no jogo com regras explícitas são capazes de desenvolver as funções psicológicas superiores (FPS) e se melhoram o desempenho escolar das crianças com histórico de insucesso escolar. A pesquisa teve como base a Psicologia histórico-cultural, principalmente nas ideias de Vygotsky, Elkonin e Leontiev. O método adotado foi o qualitativo, consistiu em uma intervenção, realizada em quatro crianças, entre 7 e 10 anos de idade, estruturada em três etapas: avaliação inicial, intervenção mediada por jogos e avaliação final. Nas avaliações foram utilizados dois instrumentos: o Teste de Desempenho Escolar (TDE), aplicado no grupo de crianças e com a família e professores foram utilizadas entrevistas semiestruturadas. Os encontros foram gravados e transcritos e as observações anotadas em diário de campo. A técnica de análise dos dados foi de conteúdo do tipo temática e microgenética. Os resultados evidenciaram que o jogo desenvolve as FPS e modifica o desempenho escolar. Conclui-se que o jogo com regras explícitas é um bom mediador entre aprendizagem e desenvolvimento em crianças que apresentam trajetórias de insucesso escolar.
Relacionamentos amorosos na contemporaneidade
Authors: Millan Marília Pereira Bueno , Vicente Reginandréa Gomes , Saito Julia Kubo , Soares de Azevedo Neto Raymundo , Santos Monique Fernandes Silva , Taborda Fernanda Falótico , Queiroz Barbara da Silva , Ronque Gleyce Kelly Teodoro , Guerreiro Angela Maciel
Published: October 2022

O presente artigo apresenta os resultados parciais de pesquisa realizada com 2778 mulheres, intitulada “Relacionamentos amorosos na contemporaneidade: quais as expectativas das mulheres?” (Millan et al., 2019), que visou à compreensão das relações afetivo-sexuais na contemporaneidade a partir da visão das mulheres e o conhecimento da dinâmica das relações com seus pares, com vistas ao manejo de conflitos nos relacionamentos afetivos e familiares, em intervenções clínicas e sociais. Teve-se como objetivo destacar aspectos relativos às diferenças entre expectativas e experiências vividas nos relacionamentos, no que diz respeito aos papéis de gênero (desempenho das tarefas domésticas e cuidados com filhos), à vida profissional, à independência financeira, aos sonhos e projetos de vida. A metodologia utilizada foi de característica quantitativa e qualitativa, com as respostas ao questionário tratadas como variáveis qualitativas ordinais e analisadas pelos testes estatísticos não paramétricos de Kruskal-Wallis ou de Mann-Whitney (1952), de acordo com o agrupamento das participantes, quanto à faixa etária, escolaridade e estado civil. As variáveis categóricas foram analisadas pelo Teste de Qui-quadrado ou pelo Teste Exato de Fisher, conforme a indicação. Na análise qualitativa, adotaram-se os referenciais psicanalítico e sistêmico. Os resultados obtidos mostram que as expectativas das mulheres nos relacionamentos amorosos são moduladas pela experiência vivida e passíveis de ajustes e reajustes durante o ciclo vital pessoal e familiar. As variáveis independentes (escolaridade, estado civil, faixa etária) influenciaram significativamente e de maneiras distintas as respostas analisadas neste artigo. Conclui-se que os relacionamentos amorosos expressam elementos próprios da contemporaneidade, na qual convivem tendências variadas de valores, condutas e pontos de vista dissonantes, em constante transformação.
estágio da concernência e a elaboração do complexo de Édipo
Authors: Almeida Alexandre Patricio , Naffah Neto Alfredo
Published: October 2022

O nosso texto toma como ideia central o referencial winnicottiano, salientando a importância de um bom atravessamento do estágio da concernência (stage of concern) – etapa que, a nosso ver, é indispensável para constituir os pilares de um psiquismo relativamente saudável, capaz de enfrentar as mazelas oriundas do conflito edipiano. Para tanto, iniciaremos o trabalho com uma breve descrição do estágio da concernência, seguida das questões relativas à ambivalência característica do Édipo propriamente dito. Por fim, tecemos algumas considerações que objetivam relacionar uma análise do caso Piggle (The Piggle), uma menina de dois anos e meio, cujo tratamento, realizado por D. W. Winnicott, ocorreu em dezesseis encontros, constituindo uma espécie de análise, de acordo com a demanda, tratando, sobretudo, questões ligadas à intensidade de sentimentos ambivalentes não elaborados pela paciente, que anteciparam o seu ingresso no complexo de Édipo antes que ela passasse, fundamentalmente, pelo estágio da concernência.
Impacto das Teorias da Conspiração em tempos de COVID-19
Authors: Rezende Alessandro Teixeira , Carneiro Jailson Santana , Soares Ana Karla Silva , Figueiredo Camilla Vieira de , Moura Hysla Magalhães de
Published: October 2022

Na conjuntura atual, a COVID- 19 representa uma séria ameaça ao bem-estar físico e psicológico da comunidade global. Por se tratar de um vírus com elevado potencial de transmissão, as orientações da Organização Mundial de Saúde para reduzir sua proliferação envolvem medidas sanitárias e ações de isolamento social. Dentre os aspectos de cunho psicológico que podem afetar as decisões de conformidade com as ações de isolamento social, pode-se considerar a crença em teorias da conspiração. Considerando a influência que tais teorias exercem sobre o comportamento das pessoas, o presente artigo teórico teve como objetivo delinear o panorama vigente sobre o estudo das crenças em teorias da conspiração no contexto da pandemia da COVID-19, bem como discutir o impacto que as mesmas exercem sobre a saúde e a conduta dos indivíduos. Em suma, este trabalho fornece subsídios para a ampliação dessa discussão a nível teórico e para o desenvolvimento de estudos empíricos considerando a realidade brasileira.
Alveolar Disease of the Liver: Classification and Surgical Interventions
Authors: Panteleev V. S. , Nartaylakov M. A. , Salimgareev I. Z. , Petrov A. S.
Published: October 2022

Introduction. There are several classifications of alveolar disease of the liver, but they do not provide complete information regarding all possible surgical interventions in terms of this pathology. Our study was aimed at identifying and structuring various approaches to staged surgical treatment of the disease, taking into account the current possibilities of minimally invasive surgery.

Materials and methods. After carrying out a retrospective analysis of surgical treatment of 72 patients with alveolar disease of liver, we have developed a classification of the surgical interventions and 6 main staged approaches to surgical treatment for the disease. Results and discussion. The presented classification of surgical interventions for alveolar disease of the liver is entirely sufficient to divide all surgeries into the following groups: radical/ relatively-radical surgical interventions that make the patient free or nearly free of the disease, and palliative/diagnostic surgeries, that focus on alleviation of the patient’s condition. In addition, the volume and radicality of the liver resection as well as the drainage of the bile ducts and liver decay cavities can be clarified. Based on the developed classification of surgical interventions, we presented 6 main staged, case-centered approaches to the surgical treatment for liver alveolar disease and its complications.

Conclusion. The presented classification of surgical interventions for alveolar disease of the liver is a way to explicitly divide the surgeries according to several criteria. Surgical treatment for alveolar disease of the liver includes various parts, which made it possible to develop 6 main options for a staged approach to surgical interventions, ensuring scientific and practical applications.
Immune Checkpoint Inhibitors in Urothelial Carcinoma (Literature Review)
Authors: Menshikov K. V. , Sultanbaev A. V. , Musin Sh. I. , Izmailov A. A. , Lipatov O. N. , Menshikova I. A. , Sultanbaeva N. I. , Popova E. V.
Published: October 2022

Bladder cancer is globally considered as one of the most aggressive neoplasms. Traditionally, first-line therapy for metastatic urothelial carcinoma has remained unchanged over the past decades and has been based on combinations of cisplatin. Unfortunately, almost all patients eventually progress and die from bladder cancer, despite the initial response associated with cisplatin-based combinations. Immune checkpoint inhibitors are becoming an increasingly widely used therapeutic option in many solid tumors. In bladder cancer, a high level of programmed death-ligand is determined by rapidly progressive and aggressive tumors and unsatisfactory survival rates. Although checkpoint inhibitors are effective in metastatic urothelial bladder cancer, only a small proportion of treated patients receive a clear benefit, while a large number of patients experience significant side effects and toxicity without improving quality of life or surviving. None of the available biomarkers at this point was associated with response rates. There is evidence of an correlation between PD-L1 expression, the efficacy of immune checkpoint inhibitors, and treatment outcomes in patients with bladder cancer. A major paradigm shift in bladder cancer medicine has followed the FDA approval of avelumab, pembrolizumab, durvalumab, atezolizumab, and nivolumab for the treatment of patients with metastatic urothelial carcinoma previously treated with chemotherapy. Combining classical clinicopathological parameters with data obtained via information technology, together with genomic profiling, could be the future of personalized therapy for bladder cancer.
Endovascular Treatment of a Patient with Multivessel Deсease Combined with Chronic Occlusion of the Right Coronary Artery
Authors: Vasiliev D. K. , Rudenko B. A. , Feshchenko D. A. , Shukurov F. B. , Shanoyan A. S.
Published: October 2022

Introduction. Coronary hagiography revealed 70%-prevalence of multivessel coronary lesions. Chronic coronary occlusion (CCO) occurs in approximately 20 % of patients with coronary heart disease. Endovascular recanalization of CCO is associated with technical difficulties and the risk of complications. In this regard, patients with CCO rarely undergo revascularization, which leads to incomplete myocardial revascularization.

Materials and methods. Patient M., male, 64, was hospitalized at the National Medical Research Center for Therapy and Preventive Medicine in February 2020 with a diagnosis of CHD. Stable angina, FC III, multivessel coronary lesions. The recanalization of chronic occlusion of the right coronary artery was performed at the first stage. During the next stage of revascularization of the left main coronary artery, an acute occlusion of the circumflex artery occurred. Despite the acute occlusion, no ischemic dynamics wasm reported on the electrocardiogram, there were no complaints, hemodynamics was stable. Ischemic events did not occur due to the formed network of collaterals out of the system of the right coronary artery. This allowed the complication to be corrected without consequences for the patient. Results and discussion. Thanks to the accumulated experience and advanced technologies, the success rate of recanalization has reached 90–95 %, and complications are not more common than in cases of stenting of non-occlusive lesions. The conducted studies have proved that successful recanalization of CCO improves the patient’s clinical and functional status, intracardiac hemodynamics and quality of life.

Conclusion. The clinical case given above clearly demonstrates the need for endovascular revascularization of CCO. The formed collateral network ensured blood flow in the area of acute occlusion and prevented the development of ischemia and myocardial infarction.
Dermatoscopy in the Diagnosis of Skin Metastases from Breast Cancer
Authors: Vashkevich A. A. , Semiletova Yu. V. , Korablina I. M. , Kalashnikova E. S. , Reztsova P. A. , Kvichidze L. G. , Pavlov R. V. , Danilin V. N. , Pavlikova I. A. , Nikitina Yu. I.
Published: October 2022

Introduction. Skin metastases are the result of skin infiltration caused by the proliferation of cells of remotely located malignant tumors occurring with a frequency of 0.6–10.4 % in various oncological processes. They may be a sign of progressive neoplasm or a manifestation of newly diagnosed cancer. Due to a high variability of clinical manifestations leading to misdiagnoses, a limited number of articles describe clinical and dermatoscopic signs of solid tumors metastatic nodes. Aim: to analyze the clinical and dermatoscopic features of skin metastases from breast cancer.

Materials and methods. A female patient has complaints of slight pain and itching in the lesions area on the scalp. According to her medical history, a right mastectomy was performed for right breast cancer in 2012, followed by hormone therapy willfully discontinued by the patient. Given the uncommon localization limited with the scalp, the differential diagnosis was made with a spectrum between a cylindroma, multiple basal cell cancer and metastatic carcinoma. A biopsy was carried out to confirm the diagnosis. Results and examination. The pathological skin process revealed itself through multiple nodes up to 2 cm in diameter, pinkish in color, dense, painless on palpation, poorly demarcated. Dermatoscopically: polymorphic vessels on an erythematous background, chrysalis-like structures. Breast cancer metastases were verified by histological and immunohistochemical examination.

Conclusion. Skin metastases may be the first sign of cancer recurrence. Dermatoscopy can facilitate differenting them from other skin diseases. Density and diameter of pathological vessels are prognostically significant. Ifdetected lesions do not fit the standard pattern of skin neoplasms, histological verification of the diagnosis is recommended to be carried out.
Implementace nové generace řídící jednotky Fischertechnik TXT 4.0 do hardwarového simulačního modelu představujícího koncept Industry 4.0
Authors: Malaga Miroslav , Ulrych Zdeněk
Published: October 2022

Článek se zabývá přechodem z řídící jednotky Fischertechnik Robotics TXT Controller na novou generaci Fischertechnik TXT 4.0 Controller se zachováním grafického způsobu programování a odesíláním dat např. do aplikace pro sběr dat z digitálního dvojčete běžící na PC. Zachováním grafického způsobu programování odpadá složité programování v jazycích C/C++ a kompilace pro linuxové jádro běžící na TXT 4.0 Controlleru a jeho ARM procesor. Navržené řešení využívá Raspberry Pi Pico jako překladač mezi sériovým portem PC a rozhraním I2C řídící jednotky Fischertechnik a oproti původnímu řešení odpadá nutnost převodníku napěťových úrovní mezi překladačem (nově RaspberryPi Pico místo Arduino UNO) a řídící jednotkou Fischertechnik. Nové řešení tak zachovává možnost využít potenciál jednotky Fischertechink TXT 4.0 Controller i studenty v oboru průmyslového inženýrství a průmyslovými inženýry všeobecně, kteří nejsou programátory.
Challenges on Distance Learning Interaction among Accounting Students at State-Run College in an Island Province in the Philippines
Authors: Avillanoza Rommel A. , Pandiño April Jane B. , Cruz Chrystal M. , Cruz Edmelyn B. , Topado Jo-Ann S.
Published: October 2022

Distance learning became more evident during the covid-19 pandemic. It became mandatory in different parts of the world just to continue the educational system despite the insufficiency of resources. This paper aimed to determine the challenges encountered by accounting students towards distance learning and their distance-learning interaction. The researchers used descriptive-correlational research. The data was gathered from 100 accounting students in a state-run college in an island province using a structured survey questionnaire and a simple random sampling technique. The study found that accounting students encountered a large extent of challenges in infrastructural limitations and state of mind while learner-learner interaction scored the highest among the types of distance learning interactions. The study also found that challenges encountered were in terms of disturbance in execution, the gap between people, and technological inhibitions having a significant and positive correlation with learner-content interaction. A negative correlation between challenges encountered in terms of the state of mind and learning-instructor interaction was also observed. The findings of the study can be used in enhancing the learning experience of the students and improvement of the learning management of the institution when implementing distance learning education.
Somatotropina bovina recombinante (rBST): El ocaso de una nueva tecnología creada en EEUU
Authors: Calcedo Ordóñez Victoriano
Published: October 2022

Se intenta seguir los acontecimientos desde el 2000 en EEUU, que sugieren las causas del fracaso en la utilización de la rBST (Posilac). El texto repasa tasa de utilización, incidencias políticas, legales y mediáticas, efectos de la utilización en producción de leche y en salud animal, impacto del consumo de leche, lácteos y carne de animales tratados en la salud humana, papel del etiquetado de la leche de vacas tratadas para el consumidor e impacto medioambiental.

Frente a la firme posición favorable de la FDA, la presión de los consumidores, el apoyo de la industria láctea y la distribución desde 2007, expresado en el etiquetado de la leche y sus productos (“rBST Free”), llevó al ocaso la nueva tecnología. La postura de los consumidores se basó fundamentalmente en sus reservas frente a la rBST en salud del consumidor, bienestar animal y salud animal.
Continuous renal replacement therapy is a safe and effective modality for the initial management of dogs with acute kidney injury
Authors: Chen Hilla , Klainbart Sigal , Kelmer Efrat , Segev Gilad
Published: October 2022

OBJECTIVE

To describe the management of dogs with acute kidney injury (AKI) by continuous renal replacement therapy (CRRT), and to investigate the relationship between a prescribed CRRT dose, the hourly urea reduction ratio (URR), and the overall efficacy.

ANIMALS

45 client-owned dogs diagnosed with severe AKI, receiving 48 CRRT treatments at a veterinary teaching hospital.

PROCEDURES

Retrospective study. Search of medical records of dogs with AKI managed by CRRT.

RESULTS

Median serum urea and creatinine at CRRT initiation were 252 mg/dL [Inter quartile range (IQR), 148 mg/dL; range, 64 to 603 mg/dL] and 9.0 mg/dL (IQR, 7 mg/dL; range, 4.3 to 42.2 mg/dL), respectively. Median treatment duration was 21 hours (IQR, 8.8 hours; range, 3 to 32 hours). Systemic heparinization and regional citrate anticoagulation were used in 24 treatments each (50%). The prescribed median CRRT dose for the entire treatment was 1 mL/kg/min (IQR, 0.4 mL/kg/min; range, 0.3 to 2.5 mL/kg/min). The median hourly URR was 4% (IQR, 1%; range, 2% to 12%), overall URR was 76% (IQR, 30%; range, 11% to 92%) and median Kt/V was 2.34 (IQR, 1.9; range, 0.24 to 7.02). The CRRT dose was increased gradually from 0.9 mL/kg/min to 1.4 mL/kg/min (P < .001) and the hourly URR decreased from 6.5% to 5.5% (P = .05). The main complication was clotting of the extra-corporeal circuit, occurring in 6/48 treatments (13%). Twenty-four dogs (53%) survived to discharge.

CLINICAL RELEVANCE

CRRT is safe when the prescription is based on the current veterinary guidelines for gradual urea reduction. Treatment efficacy can be maximized by gradually increasing the dose according to the actual URR.
Energy endocrine physiology, pathophysiology, and nutrition of the foal
Authors: Kinsella Hannah M. , Hostnik Laura D. , Toribio Ramiro E.
Published: October 2022

Most homeostatic systems in the equine neonate should be functional during the transition from intra- to extrauterine life to ensure survival during this critical period. Endocrine maturation in the equine fetus occurs at different stages, with a majority taking place a few days prior to parturition and continuing after birth. Cortisol and thyroid hormones are good examples of endocrine and tissue interdependency. Cortisol promotes skeletal, respiratory, cardiovascular, thyroid gland, adrenomedullary, and pancreatic differentiation. Thyroid hormones are essential for cardiovascular, respiratory, neurologic, skeletal, adrenal, and pancreatic function. Hormonal imbalances at crucial stages of development or in response to disease can be detrimental to the newborn foal. Other endocrine factors, including growth hormone, glucagon, catecholamines, ghrelin, adipokines (adiponectin, leptin), and incretins, are equally important in energy homeostasis. This review provides information specific to nutrition and endocrine systems involved in energy homeostasis in foals, enhancing our understanding of equine neonatal physiology and pathophysiology and our ability to interpret clinical and laboratory findings, therefore improving therapies and prognosis.
Dietary fiber aids in the management of canine and feline gastrointestinal disease
Authors: Moreno Adam A. , Parker Valerie J. , Winston Jenessa A. , Rudinsky Adam J.
Published: October 2022

Dietary fiber describes a diverse assortment of nondigestible carbohydrates that play a vital role in the health of animals and maintenance of gastrointestinal tract homeostasis. The main roles dietary fiber play in the gastrointestinal tract include physically altering the digesta, modulating appetite and satiety, regulating digestion, and acting as a microbial energy source through fermentation. These functions can have widespread systemic effects. Fiber is a vital component of nearly all commercial canine and feline diets. Key features of fiber types, such as fermentability, solubility, and viscosity, have been shown to have clinical implications as well as health benefits in dogs and cats. Practitioners should know how to evaluate a diet for fiber content and the current knowledge on fiber supplementation as it relates to common enteropathies including acute diarrhea, chronic diarrhea, constipation, and hairball management. Understanding the fundamentals of dietary fiber allows the practicing clinician to use fiber optimally as a management modality.
Solid fuel briquette from biomass: Recent trends
Authors: Mohd-Faizal Azrul Nurfaiz , Mohd-Shaid Mohd Shafiq Hakimi , Ahmad-Zaini Muhammad Abbas
Published: October 2022

Solid fuel briquette from biomass materials has gained considerable attention as sustainable replacement source of energy. The characteristics of briquette are imperative to ensure its effectiveness as fuel in a long run. This paper is aimed to summarize the key properties of solid briquette made from various natural and waste-based resources, and to highlight the future research directions in the briquette manufacture. The commentary is expected to shed insight towards the greener, cleaner, and efficient briquette materials.
Chocolate coverage based on two Ecuadorian varieties CCN51 and Super Tree in the province of Pastaza, Ecuador
Authors: Enríquez Estrella Miguel Ángel
Published: October 2022

Objective: Its objective is to produce a bitter-type chocolate coating from the combination of cocoa of the CCN51 and Super Tree variety. Methodology: the product was elaborated through an experimental, quantitative, and qualitative method. Results: 18 experimental units were generated in the design, where 2 formulations with 2 replications were obtained, which allowed us to determine the best treatment through sensory analysis with a structured hedonic scale of acceptability (assessment from 1 to 5). The sensory evaluation was carried out with 30 untrained panelists, where they determined that T1 with 70% cocoa liquor is the most accepted, while for the trained judges there was no significant difference. The samples were subjected to bromatological analysis, obtaining as a result a moisture content of 1.59%, fat 37.86%, protein 9.26%, ash 2.04%, dry extract of defatted cocoa 99.38%, dry extract of total cocoa 98.41%, microbiological less than 100 cfu. ml-1 in total mesophiles, yeasts, and total coliforms. Limitations: have pilot equipment for processing. Conclusions: The parameters of the best treatment T1 are framed in the NTE INEN 621: 2010 in force in Ecuador for the manufacture of chocolates.
Gaussian Mixture Model-Based Online Anomaly Detection for Vectored Area Navigation Arrivals
Authors: Choi Hong-Cheol , Deng Chuhao , Park Hyunsang , Hwang Inseok
Published: October 2022

Identifying anomalous flight trajectories is crucial in airspace operations, as they can potentially lead to safety risks. One of the challenges in identifying abnormal aircraft trajectories in the vectored area navigation (RNAV) terminal airspace is distinguishing between anomalies and trajectories vectored from the structured procedures. Applying existing trajectory pattern identification algorithms to vectored trajectories could create patterns with wide variation within; hence, they cannot effectively discern anomalies from nominal vectored trajectories. In addition, most existing anomaly detection algorithms are developed to detect anomalies in historical air traffic surveillance data, and thus, they cannot be readily applicable for online implementation. To address these problems, an online anomaly detection algorithm for vectored flights in RNAV terminal airspace based on the Gaussian mixture model (GMM) is proposed, which can deal with highly complex airspace operations by incorporating the GMM with dynamic trajectory pattern classification and hybrid trajectory prediction. The proposed algorithm is demonstrated with real air traffic surveillance data at Incheon International Airport (ICN), South Korea.
Wall-Resolved Large-Eddy Simulation of Near-Stall Airfoil Flow at Rec=107
Authors: Tamaki Yoshiharu , Kawai Soshi
Published: October 2022

A wall-resolved large-eddy simulation (LES) of the near-stall flow around the Aerospatiale A-airfoil at [Formula: see text] is conducted. The present LES shows typical Reynolds-number effects compared to the previous LES at [Formula: see text], such as the increase in lift coefficient, decrease in boundary-layer thickness, delay of turbulent flow separation, and upstream shift of transition location. Among these Reynolds-number effects, the difference in the development of momentum displacement thickness is focused on and further analyzed based on the integral relation of the boundary layer. This analysis reveals that the different mechanisms of the laminar–turbulent transition between the two Reynolds-number cases cause an initial difference in the momentum displacement thickness. This initial difference is then amplified downstream by the deceleration effects of the mean flow. These results suggest that proper estimation of the laminar and transitional flows near the leading edge is crucial for predicting the trailing-edge stall phenomena and their dependency on the Reynolds number.
Transpiration-Cooling Heat Transfer Experiments in Laminar and Turbulent Hypersonic Flows
Authors: Naved Imran , Hermann Tobias , Hambidge Chris , Saad Ifti Hassan , Falsetti Chiara , McGilvray Matthew , Tirichenko Iullia S , Vandeperre Luc
Published: October 2022

The design of a transpiration-cooled system requires detailed local heat transfer information on and in the vicinity of the porous injector; however, limited spatially resolved experimental studies exist, particularly in hypersonic flows. In this work, experiments were conducted in the University of Oxford’s high-density tunnel at Mach 6.1 in both laminar and turbulent regimes. Spatially resolved two-dimensional surface heat transfer measurements were acquired by imaging directly on and downstream of two microporous transpiration-cooled injectors (METAPOR® CE170 and zirconia) using high-speed infrared thermography. Whereas injection in the laminar regime results in a steady, monotonic reduction in heat transfer from the start of the injector, a flatter profile is present for the turbulent cases where turbulent mixing inhibits surface heat transfer reduction. It was found that a modification to existing relations from film theory successfully correlates the streamwise heat transfer distribution on the injector for different blowing rates of nitrogen and helium. A key result is that helium performs much better than reported in previous experiments. Finally, the downstream thermal effectiveness is characterized for turbulent flows. A collapse of the thermal effectiveness is achieved and a modified analytical correlation proposed.
PENERAPAN MODEL VECTOR AUTOREGRESSIVE ORDE TIGA PADA DATA SUHU UDARA RATA-RATA DI KABUPATEN MALANG DAN KABUPATEN SIDOARJO
Authors: Salsabila Salsabila , Kusuma Dianne Amor , Ruchjana Budi Nurani
Published: October 2022

Perubahan iklim berdampak sangat luas pada kehidupan masyarakat. Salah satu unsur yang memengaruhi perubahan iklim yaitu suhu udara. Perubahan iklim di beberapa wilayah tidak hanya dipengaruhi oleh satu waktu. Perubahan iklim di suatu wilayah dapat dipengaruhi oleh dua atau tiga waktu sebelumnya. Perubahan iklim dari waktu ke waktu dapat diketahui melalui analisis deret waktu. Penelitian ini bertujuan untuk menaksir parameter model Vector Autoregressive orde tiga (VAR (3)) menggunakan metode Ordinary Least Squares (OLS) serta menerapkan model VAR (3) pada data suhu udara rata-rata di Kabupaten Malang dan Kabupaten Sidoarjo. Nilai peramalan yang diperoleh selama 10 periode telah mendekati nilai aktual dengan nilai MAPE berturut-turut adalah  dan . Berdasarkan kriteria nilai MAPE, nilai MAPE  menunjukkan hasil peramalan sangat akurat sehingga penelitian ini dapat menjadi bahan referensi bagi lembaga peneliti, perguruan tinggi, maupun peneliti lain dalam menerapkan model VAR (3) pada data suhu udara rata-rata dengan menggunakan bantuan software R.
PENGEMBANGAN LEMBAR KERJA SISWA DALAM MATERI MATEMATIKA PADA KELAS VIII BERBASIS THEORY OF DIDACTICAL SITUATION
Authors: Zulkarnaen Rafiq , Darmawan Budi Arif , Ruli Redo Martila
Published: October 2022

Penelitian ini bertujuan untuk menghasilkan lembar kerja siswa dalam matematika untuk kelas VIII berdasarkan theory of didactical situation. Penelitian dan pengembangan model Plomp digunakan dalam penelitian ini, yang terdiri dari tahap penelitian pendahuluan, pembuatan dan penilaian prototype. Penelitian pendahuluan dilakukan untuk menghasilkan model epistemologi, sedangkan tahap prototyping dan assessment digunakan untuk menguji keefektifan dan kepraktisan LKS melalui penilaian diri sendiri, penilaian pakar, uji satu-satu, ujicoba terbatas, dan ujicoba lapangan. LKS yang dikembangkan berdasarkan teori situasi didaktis pada materi Teorema Pythagoras, Ruas Sisi Datar, Lingkaran, Statistika, dan Probabilitas dinyatakan valid, praktis, dan berpotensi efektif. Berdasarkan hasil tahap prototyping dan penilaian disimpulkan bahwa LKS valid dengan kompetensi matematika, tujuan pembelajaran, dan menyediakan situasi adidaktis, situasi didaktis, dan lingkungan. Kepraktisan untuk memudahkan guru dan siswa menggunakan LKS yang telah dikembangkan untuk diimplementasikan di kelas. Selanjutnya, keefektifan LKS mempengaruhi siswa untuk dapat merumuskan masalah dan menemukan solusi serta membangun pengetahuan matematika secara mandiri.
ALGORITMA MODULO BERPANGKAT MENGGUNAKAN TEOREMA BINOMIAL NEWTON DAN PHI EULER DENGAN JAVASCRIPT
Authors: Rhomdani Rohmad Wahid
Published: October 2022

Tujuan dari penelitian ini mengembangkan aplikasi modulo berpangkat menggunakan javascript. Metode penelitian yang digunakan adalah studi literatur yaitu mengkaji teorema Euler dan Binomial Newton untuk menguji dan menyelidiki modulo berpangkat ab mod n adakah solusi penyelesaian menggunakan Teorema Binomial Newton dengan bantuan nilai Phi Euler. Peneliti melakukan pengujian dengan javascript untuk menentukan nilai phi euler aφ(n) mod n = 1. Peneliti berhasil mengembangkan dan membuat aplikasi matematika modulo berpangkat dengan algoritma javascript dan dapat memberikan penyelesaian modulo berpangkat yang akurat menggunakan teorema binomial newton dengan bantuan nilai phi euler dan pola barisan.
An Analysis of Violent Attacks in Gauteng, South Africa, in 2019: Xenophobic or Not? – That is the Question
Authors: Kole Olaotse John
Published: October 2022

Despite the democratic dispensation, crime levels, especially violent attacks, are high in South Africa. Violent attacks were widespread during the apartheid era. Unfortunately, violence continues to be a means people use to protest or register their discontent. Currently, the critical issues that ignite protests are scarce resources and poor service delivery by the local government. In addition, there are territorial conflicts within South Africa, in which South Africans who reside in parts of the country that are not their birthplaces find it difficult to work in these areas because the local people accuse them of stealing their jobs. Vigilantes give this excuse for unleashing attacks on fellow South Africans. Recently, this hostility has extended to foreign nationals living in South Africa. This paper investigates whether the violent attacks that took place in Gauteng, South Africa, in 2019 were xenophobic. A qualitative research method was used. Semi-structured interviews were conducted with six participants. The findings indicated that the violent incidents that occurred in 2019 were associated with criminal elements and were not xenophobic attacks on foreign nationals. In addition, the study found that the media played a crucial role in misreporting the incidents.