bluuebunny/crossref_metadata_2025 huggingface dataset:
Effects of Changes in Multiple Chronic Conditions on Medical Costs among Older Adults in South Korea
Authors: Park Soojin , Nam Jin Young
Published: April 2022

This study aims to analyze the relationship between cognitive function and out-of-pocket cost of the state change of multiple chronic conditions in individuals aged 60 or older. Data from the 2014 to 2018 Korean Longitudinal Study of Aging were used for 2202 older adults who were cognitively “normal” at the start of the survey. Four status change groups were established (“Good → Good,” “Good → Bad,” “Bad → Good,” and “Bad → Bad”) according to the change in the number of chronic diseases. Generalized estimating equation modeling analyzed the association between these changes and out-of-pocket medical cost. Out-of-pocket cost was significantly higher among older adults with multiple chronic conditions (p < 0.0001). Total out-of-pocket medical cost and out-of-pocket cost for outpatient care and prescription drugs were significantly higher for Bad→ Bad or Good → Bad changes. Older adults with cognitive decline had significantly higher total out-of-pocket medical cost and out-of-pocket cost for prescription drugs. This study demonstrates the need to improve the multiple chronic conditions management construction model to enhance the health of older adults in Korea and secure national health care finances long-term. It provides a foundation for related medical and medical expenses-related systems.
A Time-Dependent Analysis of Association between Acupuncture Utilization and the Prognosis of Ischemic Stroke
Authors: Choi Sung-Ryul , Kim Eun-San , Jang Bo-Hyoung , Jung Boyoung , Ha In-Hyuk
Published: April 2022

This study investigated the time-dependent characteristics of acupuncture and analyzed the association between acupuncture utilization and mortality rates, readmission rates, and complications among ischemic stroke patients. Data from the National Health Insurance Service-National Sample Cohort 2.0 from South Korea were used to track patients with subacute and chronic ischemic stroke, who had survived more than one month after onset, between 2010 and 2013. A total of 2299 patients were followed up until 2015. At baseline, the acupuncture group (n = 195) and the control group (n = 2104) had similar ages (acupuncture group: 69.0 ± 11.1 years; control group: 68.5 ± 11.8 years), but the acupuncture group had more comorbidities (Charlson comorbidity index; acupuncture group: 4.7 ± 2.1, control group: 4.3 ± 2.4). According to time-dependent Cox regression survival analysis, acupuncture treatment was associated with low hazard ratios (HR) for death (HR: 0.32; 95% confidence interval (CI): 0.18–0.60), fewer composite complications (HR: 0.34; 95% CI: 0.21–0.53), and reduced urinary tract infection (HR: 0.24; 95% CI: 0.11–0.54). Many acupuncture session sensitivity analyses were performed to assess the robustness using different criteria to define the acupuncture group, and the results were consistent with those of the main analysis. Therefore, acupuncture treatment might be associated with lower mortality rates and the prevention of complications after ischemic stroke.
An Effective Strategy and Mathematical Model to Predict the Sustainable Evolution of the Impact of the Pandemic Lockdown
Authors: Harjule Priyanka , Poonia Ramesh Chandra , Agrawal Basant , Saudagar Abdul Khader Jilani , Altameem Abdullah , Alkhathami Mohammed , Khan Muhammad Badruddin , Hasanat Mozaherul Hoque Abul , Malik Khalid Mahmood
Published: April 2022

There have been considerable losses in terms of human and economic resources due to the current coronavirus pandemic. This work, which contributes to the prevention and control of COVID-19, proposes a novel modified epidemiological model that predicts the epidemic’s evolution over time in India. A mathematical model was proposed to analyze the spread of COVID-19 in India during the lockdowns implemented by the government of India during the first and second waves. What makes this study unique, however, is that it develops a conceptual model with time-dependent characteristics, which is peculiar to India’s diverse and homogeneous societies. The results demonstrate that governmental control policies and suitable public perception of risk in terms of social distancing and public health safety measures are required to control the spread of COVID-19 in India. The results also show that India’s two strict consecutive lockdowns (21 days and 19 days, respectively) successfully helped delay the spread of the disease, buying time to pump up healthcare capacities and management skills during the first wave of COVID-19 in India. In addition, the second wave’s severe lockdown put a lot of pressure on the sustainability of many Indian cities. Therefore, the data show that timely implementation of government control laws combined with a high risk perception among the Indian population will help to ensure sustainability. The proposed model is an effective strategy for constructing healthy cities and sustainable societies in India, which will help prevent such a crisis in the future.
Impact of Pseudomonas sp. SVB-B33 on Stress- and Cell Wall-Related Genes in Roots and Leaves of Hemp under Salinity
Authors: Berni Roberto , Hausman Jean-Francois , Villas-Boas Silas , Guerriero Gea
Published: April 2022

Salinity is a type of abiotic stress that negatively affects plant growth and development. Textile hemp (Cannabis sativa L.) is an important multi-purpose crop that shows sensitivity to salt stress in a genotype- and developmental stage-dependent manner. The root and shoot biomasses decrease in the presence of NaCl during vegetative growth and several stress-responsive genes are activated. Finding environmentally friendly ways to increase plant health and resilience to exogenous stresses is important for a sustainable agriculture. In this context, the use of beneficial bacteria, collectively referred to as plant growth-promoting bacteria (PGPB), is becoming an attractive and emergent agricultural strategy. In this study, data are provided on the effects of a Pseudomonas isolate (Pseudomonas sp. SVB-B33) phylogenetically closely related to P. psychrotolerans applied via roots to salt-stressed hemp. The application of both living and dead bacteria impacts the fresh weight of the root biomass, as well as the expression of several stress-related genes in roots and leaves. These results pave the way to future investigations on the use of Pseudomonas sp. SVB-B33 in combination with silica to mitigate stress symptoms and increase the resilience to other forms of exogenous stresses in textile hemp.
Using a Bed Sill as a Countermeasure for Clear-Water Scour at a Complex Pier with Inclined Columns Footed on Capped Piles
Authors: Esmaeili Varaki Mahdi , Tavazo Negar , Radice Alessio
Published: April 2022

River bridge piers may collapse due to the local scour around their foundations. It is known that local scour is an effect of the three-dimensional flow field that develops near the pier and that the geometric complexity of a non-cylindrical pier may, correspondingly, increase the complexity of the process. It is also known that various devices may be used as scour countermeasures. This manuscript explores the use of a bed sill as a countermeasure for local scour at a complex bridge pier compound of an array of piles, a pile cap, and two inclined columns with the rectangular sections above the cap. This pier geometry, never studied before in combination with a scour countermeasure, was stimulated by an existing bridge. Different sill placements were tested (at the upstream or downstream edges of the pier, or in an intermediate position) for various values of the pile diameter and number, cap thickness and cap elevation. The results of a wide experimental campaign consistently showed that the most effective placement of the transverse sill was at the upstream edge of the pier, for which scour reductions of up to 30–40% could be obtained for the long-term scour depth. The countermeasure performance decreased to about 10% when the sill was placed at the downstream edge of the pier. Furthermore, the installation of a transverse sill upstream of the pier also changed the shape of the scour hole because the pier was then located in an area prone to sill scour; however, for the present experiments, the combination of the effects was beneficial in terms of the resulting scour depth. Although the investigation of a single hydro-dynamic condition prevents the experimental findings from being generalized, the promising results stimulate further consideration of a transverse sill as a countermeasure for local scour at a complex pier.
Exploring the Relationship between Urban Youth Sentiment and the Built Environment Using Machine Learning and Weibo Comments
Authors: Duan Sutian , Shen Zhiyong , Luo Xiao
Published: April 2022

As the relationship between the built environment and the sense of human experience becomes increasingly important, emotional geography has begun to focus on sentiments in space and time and improving the quality of urban construction from the perspective of public emotion and mental health. While youth is a powerful force in urban construction, there are no studies on the relationship between urban youth sentiments and the built environment. With the development of the Internet, social media has provided a large source of data for the metrics of youth sentiment. Based on data from more than 10,000 geolocated Sina Weibo comments posted over one week (from 19 to 25 July 2021) in Shanghai and using a machine learning algorithm for attention mechanism, this study calculates the sentiment label and sentiment intensity of each comment. Ten elements in five aspects were selected to assess the built environment at different scales and also to explore the correlations between built environment elements and sentiment intensity at different scales. The study finds that the overall sentiment of Shanghai youth tends to be negative. Sentiment intensity is significantly associated with most built environment elements at smaller scales. Urban youth have a higher proportion of both happy and sad sentiments, within which sad sentiments are more closely related to the built environment and are significantly related to all built environment elements. This study uses a deep learning algorithm to improve the accuracy of sentiment classification and confirms that the built environment has a great impact on sentiment. This research can help cities develop built environment optimization measures and policies to create positive emotional environments and enhance the well-being of urban youth.
Population-Based Analysis of Trends in Incidence and Survival of Human Papilloma Virus-Related Oropharyngeal Cancer in a Low-Burden Region of Southern Europe
Authors: Rubió-Casadevall Jordi , Ciurana Elna , Puigdemont Montserrat , Sanvisens Arantza , Marruecos Jordi , Miró Josefina , Urban Antoni , Palhua Rosa-Lisset , Martín-Romero Ferran , Ortiz-Duran Maria Rosa , Marcos-Gragera Rafael
Published: April 2022

Introduction: Human papilloma virus (HPV)-related oropharyngeal carcinoma (OPC) can be considered a new subtype of cancer with different clinical characteristics and prognosis than that related to tobacco. Its incidence is increasing worldwide. Its epidemiology has been widely studied in areas such as North America and Northern Europe, but less is known in Southern Europe. Methods: We analyzed the epidemiology of OPC using the database from Girona’s population-based Cancer Registry, in the North-East of Spain, from 1994 to 2018. To analyze differences between neoplasms related to human papillomavirus or not, we determined the immunohistochemical expression of p16 in cases within four time periods: 1997–1999, 2003–2005, 2009–2011, and 2016–2018. Results: Oropharyngeal cancer incidence increased significantly from 2001 to 2018 with an Annual Percentage of Change (APC) of 4.1. OPC p16-positive cases increased with an APC of 11.1. In the most recent period, 2016–2018, 38.5% of OPC cases were p16-positive. European age-standardized incidence rate was 4.18 cases/100.000 inhabitants-year for OPC cancer and 1.58 for those p16-positive. Five-year observed survival was 66.3% for p16-positive OPC and 37.7% for p16-negative. Conclusions: Although with lower burden than in other regions, p16-positive oropharyngeal cancer is increasing in our area and has a better prognosis than p16-negative OPC.
Association of Health and Psychological Factors with Academic Achievement and Non-Verbal Intelligence in University Students with Low Academic Performance: The Influence of Sex
Authors: Brambila-Tapia Aniel Jessica Leticia , Miranda-Lavastida Aris Judit , Vázquez-Sánchez Nancy Araceli , Franco-López Nancy Lizbeth , Pérez-González Martha Catalina , Nava-Bustos Gonzalo , Gutiérrez-Rodríguez Francisco José , Mora-Moreno Francisco Fabián
Published: April 2022

Academic achievement, measured with the grade point average (GPA), is a stable characteristic that has been associated with many sociodemographic and psychological variables; however, the relation of these variables with GPA has not been totally elucidated. The objective of this study was to perform an association of health, psychological and personal variables with GPA and non-verbal intelligence in low-academic performance population according to sex. We invited health sciences university students who had failed the same subject twice to complete a set of sociodemographic and psychological variables and a non-verbal intelligence test. The GPA, admission exam test and preparatory GPA were obtained. We included 124 students, and found that GPA was associated with non-verbal intelligence in women but not in men; in whom, having a job and having a romantic partner, were more correlated. In women, positive relations with others, emotion perception and weekly physical activity hours were marginally correlated with GPA; while in men, emotion regulation and self-motivation had a tendency of correlation with GPA. In addition, we found that non-verbal intelligence was associated somatization and the number of diseases in women. Academic achievement is regulated by different variables in each sex; therefore, intervention programs addressed by sex are needed to increase it.
Effects of Interactive Music Tempo with Heart Rate Feedback on Physio-Psychological Responses of Basketball Players
Authors: Chen Chung-Chiang , Chen Yi , Tang Li-Chuan , Chieng Wei-Hua
Published: April 2022

This paper introduces an interactive music tempo control with closed-loop heart rate feedback to yield a sportsperson with better physio-psychological states. A total of 23 participants (13 men, 10 women; 16–32 years, mean = 20.04 years) who are professionals or school team members further guide a sportsperson to amend their physical tempo to harmonize their psychological and physical states. The self-tuning mechanism between the surroundings and the human can be amplified using interactive music tempo control. The experiments showed that listening to interactive music had a significant effect on the heart rate and rating of perceived exertion (RPE) of the basketball player compared to those listening to asynchronous music or no music during exercise (p < 0.01). Synchronized interactive music allows athletes to increase their heart rate and decrease RPE during exercise and does not require a multitude of preplanned playlists. All self-selected songs can be converted into sports-oriented music using algorithms. The algorithms of synchronous and asynchronous modes in this study can be adjusted and applied to other sports fields or recovery after exercise. In the future, other musical parameters should be adjusted in real-time based on physiological signals, such as tonality, beats, chords, and orchestration.
Economic Evaluation of Nemonoxacin, Moxifloxacin and Levofloxacin in the Treatment of Early Community-Acquired Pneumonia with Possible Pulmonary Tuberculosis
Authors: Zhao Mingye , Chi Zhuoyuan , Pan Xingming , Yin Yue , Tang Wenxi
Published: April 2022

The Chinese community-acquired pneumonia (CAP) Diagnosis and Treatment Guideline 2020 recommends quinolone antibiotics as the initial empirical treatment options for CAP. However, patients with pulmonary tuberculosis (PTB) are often misdiagnosed with CAP because of the similarity of symptoms. Moxifloxacin and levofloxacin have inhibitory effects on mycobacterium tuberculosis as compared with nemonoxacin, resulting in delayed diagnosis of PTB. Hence, the aim of this study is to compare the cost-effectiveness of nemonoxacin, moxifloxacin and levofloxacin in the treatment of CAP and to determine the value of these treatments in the differential diagnosis of PTB. Primary efficacy data were collected from phase II-III randomized, double-blind, multi-center clinical trials comparing nemonoxacin to moxifloxacin (CTR20130195) and nemonoxacin to levofloxacin (CTR20140439) for the treatment of Chinese CAP patients. A decision tree was constructed to compare the cost-utility among three groups under the perspective of healthcare system. The threshold for willingness to pay (WTP) is 1–3 times GDP per capita ($11,174–33,521). Scenarios including efficacy and cost for CAP patients with a total of 6% undifferentiated PTB. Sensitivity and scenario analyses were performed to test the robustness of basic analysis. The costs of nemonoxacin, moxifloxacin, and levofloxacin were $903.72, $1053.59, and $1212.06 and the outcomes were 188.7, 188.8, and 188.5 quality-adjusted life days (QALD), respectively. Nemonoxacin and moxifloxacin were dominant compared with levofloxacin, and the ICER of moxifloxacin compared with nemonoxacin was $551,643, which was much greater than WTP; therefore, nemonoxacin was the most cost-effective option. Regarding patients with PTB who were misdiagnosed with CAP, taking nemonoxacin could save $290.76 and $205.51 when compared with moxifloxacin and levofloxacin and resulted in a gain of 2.83 QALDs. Our findings demonstrate that nemonoxacin is the more economical compared with moxifloxacin and levofloxacin, and non-fluoroquinolone antibiotics are cost-saving and utility-increasing compared to fluoroquinolones in the differential diagnosis of PTB, which can help healthcare system in making optimal policies and help clinicians in the medication of patients.
Post-COVID-19 Tourists’ Preferences, Attitudes and Travel Expectations: A Study in Guayaquil, Ecuador
Authors: Orden-Mejía Miguel , Carvache-Franco Mauricio , Huertas Assumpció , Carvache-Franco Wilmer , Landeta-Bejarano Nathalie , Carvache-Franco Orly
Published: April 2022

Expectations about a destination influence the tourist experience during the travel process stages. In the post-COVID-19 normalcy, people are adjusting their priorities and social values. Therefore, it becomes crucial to identify tourists’ expectations before traveling. The objectives of this research were: (a) identify the preferences of tourists; (b) establish the attitudes of tourists; and (c) determine the expectations of tourists for post-COVID-19 destination selection. The study analyzed a sample of 491 people during pandemic lockdowns in Guayaquil, Ecuador. Statistical techniques such as exploratory and confirmatory factor analysis were used in data analysis. The results show that after the pandemic, tourists prefer urban tourism, followed by cultural tourism and traveling with relatives. It also shows a more responsible and supportive attitude when traveling. Likewise, the results support the dimensional structure that explains a set of post-pandemic tourist expectations. Five factors were identified: Smart Care, pricing strategy, safety, comfort, and social distancing. Finally, the theoretical and managerial implications of the results that will guide for tourism destination managers were discussed.
Impact of the DRD2 Polymorphisms on the Effectiveness of the Training Program
Authors: Świtała Katarzyna , Bojarczuk Aleksandra , Hajto Jacek , Piechota Marcin , Buryta Maciej , Leońska-Duniec Agata
Published: April 2022

Dopamine receptor D2 gene (DRD2) polymorphisms have been associated with cognitive abilities, obesity, addictions, and physical-activity-related behaviors, which may underlie differences in the effectiveness of training programs. What is not yet clear is the impact of DRD2 polymorphisms on the effectiveness of exercise programs. Thus, the aim of this study was to investigate the association between the DRD2 polymorphic sites (rs1076560, rs12364283, rs1799732, rs1800497, and rs1800498) and the body’s response to regular physical activity. We studied genotypes and haplotypes distribution in a group of 165 females measured for body mass and body composition measurements, lipid profile, and glucose levels before and after realization of a 12-week training program. When tested individually, statistical analyses revealed one significant genotype by training interaction under the general model (for the basal metabolic rate, BMR, p = 0.033). Carriers of the rs1076560 CC genotype exhibited a decrease in BMR in response to training (p = 0.006). Haplotype analyses also showed that (i) the CACCC and CACTT haplotypes were associated with a post-training decrease in glucose level (β = −4.11, p = 0.032; β = −6.86, p = 0.020, respectively); (ii) the CGCCT with an increase in BMR (β = 0.65, p = 0.003) and fat free mass (FFM, β = 1.20, p = 0.009); (iii) the CA-CT with a decrease in low-density lipoprotein cholesterol (LDL, β = −17.26, p = 0.046). These results provide some evidence that the DRD2 polymorphisms may play a role in post-training changes in lipid and carbohydrate metabolism, and, as a consequence, in the effectiveness of training programs.
Lockdown Efficacy in Controlling the Spread of COVID-19 May Be Waning Due to Decline in Public Compliance, Especially among Unvaccinated Individuals: A Cross-Sectional Study in Israel
Authors: Bodas Moran , Adini Bruria , Jaffe Eli , Kaim Arielle , Peleg Kobi
Published: April 2022

Public compliance is paramount for the success of public health measures and decision making, such as lockdowns, in controlling the spread of diseases. The aim of this population-based cross-sectional study was to investigate the level of reported compliance with home isolation among the adult Israeli population (n = 940) during the first three national lockdowns, compliance with a potential fourth national lockdown if enacted, risk perception of COVID-19, vaccination uptake status, perceived effectiveness of the vaccine, and compliance with additional protective health behaviors (e.g., mask wearing and social distancing). Following widespread compliance with initial lockdowns (90.7% reported “high” or “very high” compliance), as few as 60.1% of participants indicated that they would comply with a fourth lockdown if the government decides to enact it. Non-vaccinated individuals reported the lowest levels of compliance with previous lockdowns, compared to participants who received one or two vaccines and participants vaccinated with three doses. Adjusted for gender and age, the results suggest that fearing being infected with COVID-19, perceiving the vaccine to be effective, and reporting being compliant with other health behaviors—such as mask wearing and maintaining social distance from others—are predictors of lockdown compliance. Considering the effect of pandemic lockdown fatigue, there is little support for additional lockdowns among the Israeli public, unless dramatic changes occur in the characteristics of the COVID-19 pandemic. Compliance with lockdowns is reduced among individuals who are at higher risk of contracting COVID-19, therefore rendering this non-pharmaceutical intervention even less effective in reducing the spread of the disease.
Sex Differences in VO2max and the Impact on Endurance-Exercise Performance
Authors: Santisteban Kelsey J. , Lovering Andrew T. , Halliwill John R. , Minson Christopher T.
Published: April 2022

It was not until 1984 that women were permitted to compete in the Olympic marathon. Today, more women than men participate in road racing in all distances except the marathon where participation is near equal. From the period of 1985 to 2004, the women’s marathon record improved at a rate three times greater than men’s. This has led many to question whether women are capable of surpassing men despite the fact that there remains a 10–12% performance gap in all distance events. The progressive developments in sports performance research and training, beginning with A.V. Hill’s establishment of the concept of VO2max, have allowed endurance athletes to continue performance feats previously thought to be impossible. However, even today women are significantly underrepresented in sports performance research. By focusing more research on the female physiology and sex differences between men and women, we can better define how women differ from men in adapting to training and potentially use this information to improve endurance-exercise performance in women. The male advantage in endurance-exercise performance has commonly been attributed to their higher VO2max, even when expressed as mL/kg/min. It is widely known that oxygen delivery is the primary limiting factor in elite athletes when it comes to improving VO2max, but little research has explored the sex differences in oxygen delivery. Thus, the purpose of this review is to highlight what is known about the sex differences in the physiological factors contributing to VO2max, more specifically oxygen delivery, and the impacts on performance.
The Effect of Alcohol Drinking on Metabolic Syndrome and Obesity in Koreans: Big Data Analysis
Authors: Park Eun Jung , Shin Hye Jung , Kim Sung Soo , Kim Ki Eun , Kim Sun Hyun , Kim Youl Ri , Chung Kyong Mee , Han Kyung Do
Published: April 2022

The purpose of this study was to assess the effect of alcohol consumption on metabolic syndrome (MetS) and obesity in Koreans by analysis of big data from the National Health Insurance Service health checkup database. A total of 26,991,429 subjects aged 20 years or older were included. Alcohol consumption was divided into five groups: nondrinkers, ≤7.0 g/d, 7.1–14.0 g/d, 14.1–28.0 g/d, ≥28.1 g/d. Logistic regression analyses were performed after adjusting for age, exercise, smoking, and income. The odds ratios (ORs) of MetS and obesity in men and women were lowest at ≤7.0 g/d, similar to that of the nondrinkers at 7.1–14.0 g/d, and increased with the alcohol consumption. At 7.1–14.0 g/d in older men, the ORs of metabolic syndrome and obesity were similar to those in the nondrinkers, but the OR of obesity was slightly increased in older women. This study suggests that the risk of MetS and obesity may be higher in Korean men, women, and the elderly who drink more than 14 g/d than the nondrinkers. In people with obesity or abdominal obesity, or those who need to manage their blood pressure, glucose, or triglyceride, drinking more than 7 g/d may increase the risk of MetS.
Generativity and Gendered Pathways to Health: The Role of Human, Social, and Financial Capital Past Mid-Life
Authors: Chen Yu-Chih , Hung Natalee , Lau Bobo H. P. , Choy Yung Rebecca M. P. , Fung Ellmon S. M. , Chan Cecilia L. W.
Published: April 2022

Generativity has recently received increasing attention as a key contributor to healthy aging. Personal resources and social expectations are shown to influence the desire to be generative and that generativity affects later-life health. However, whether generativity has a mediating role in linking its driving factors and health, and how gender may affect these pathways, is underexplored. Cross-sectional online data from 1085 Hong Kong residents aged 45+ were collected between November and December 2020. Latent variable path analysis was used to examine the mediating effect of generativity between human, social, and financial capital, and physical and mental well-being. Gendered pathways were investigated using multi-group analysis. Results showed that human, social, and financial capital contributed to better health through generativity, and gendered pathways were observed. Human capital had a stronger effect on generativity for men, but for women, social capital was vital for increased generativity and consequently improved health. Findings suggested that health benefits of generativity depend on different capital drivers and differ by gender. Implications for program development that aim to facilitate health should include generativity components that maximize physical and psychosocial engagement so that individuals can reap the health benefits through contributions to others.
A Trade-Off Algorithm for Solving p-Center Problems with a Graph Convolutional Network
Authors: Liang Haojian , Wang Shaohua , Li Huilai , Ye Huichun , Zhong Yang
Published: April 2022

The spatial optimization method between combinatorial optimization problems and GIS has many geographical applications. The p-center problem is a classic NP-hard location modeling problem, which has essential applications in many real-world scenarios, such as urban facility locations (ambulances, fire stations, pipelines maintenance centers, police stations, etc.). This study implements two methods to solve this problem: an exact algorithm and an approximate algorithm. Exact algorithms can get the optimal solution to the problem, but they are inefficient and time-consuming. The approximate algorithm can give the sub-optimal solution of the problem in polynomial time, which has high efficiency, but the accuracy of the solution is closely related to the initialization center point. We propose a new paradigm that combines a graph convolution network and greedy algorithm to solve the p-center problem through direct training and realize that the efficiency is faster than the exact algorithm. The accuracy is superior to the heuristic algorithm. We generate a large amount of p-center problems by the Erdos–Renyi graph, which can generate instances in many real problems. Experiments show that our method can compromise between time and accuracy and affect the solution of p-center problems.
Evaluating Methods for Efficient Community Detection in Social Networks
Authors: Kanavos Andreas , Voutos Yorghos , Grivokostopoulou Foteini , Mylonas Phivos
Published: April 2022

Exploring a community is an important aspect of social network analysis because it can be seen as a crucial way to decompose specific graphs into smaller graphs based on interactions between users. The process of discovering common features between groups of users, entitled “community detection”, is a fundamental feature for social network analysis, wherein the vertices represent the users and the edges their relationships. Our study focuses on identifying such phenomena on the Twitter graph of posts and on determining communities, which contain users with similar features. This paper presents the evaluation of six established community-discovery algorithms, namely Breadth-First Search, CNM, Louvain, MaxToMin, Newman–Girvan and Propinquity Dynamics, in terms of four widely used graphs and a collection of data fetched from Twitter about man-made and physical data. Furthermore, the size of each community, expressed as a percentage of the total number of vertices, is identified for the six particular algorithms, and corresponding results are extracted. In terms of user-based evaluation, we indicated to some students the communities that were extracted by every algorithm, with a corresponding user and their tweets in the grouping and considered three different alternatives for the extracted communities: “dense community”, “sparse community” and “in-between”. Our findings suggest that the community-detection algorithms can assist in identifying dense group of users.
Genome-Wide Screening of Transposable Elements in the Whitefly, Bemisia tabaci (Hemiptera: Aleyrodidae), Revealed Insertions with Potential Insecticide Resistance Implications
Authors: Zidi Marwa , Klai Khouloud , Confais Johann , Chénais Benoît , Caruso Aurore , Denis Françoise , Khemakhem Maha Mezghani , Casse Nathalie
Published: April 2022

Transposable elements (TEs) are genetically mobile units that move from one site to another within a genome. These units can mediate regulatory changes that can result in massive changes in genes expression. In fact, a precise identification of TEs can allow the detection of the mechanisms involving these elements in gene regulation and genome evolution. In the present study, a genome-wide analysis of the Hemipteran pest Bemisia tabaci was conducted using bioinformatics tools to identify, annotate and estimate the age of TEs, in addition to their insertion sites, within or near of the defensome genes involved in insecticide resistance. Overall, 1,292,393 TE copies were identified in the B. tabaci genome grouped into 4872 lineages. A total of 699 lineages were found to belong to Class I of TEs, 1348 belong to Class II, and 2825 were uncategorized and form the largest part of TEs (28.81%). The TE age estimation revealed that the oldest TEs invasion happened 14 million years ago (MYA) and the most recent occurred 0.2 MYA with the insertion of Class II TE elements. The analysis of TE insertion sites in defensome genes revealed 94 insertions. Six of these TE insertions were found within or near previously identified differentially expressed insecticide resistance genes. These insertions may have a potential role in the observed insecticide resistance in these pests.
Endocardial Regulation of Cardiac Development
Authors: Feulner Lara , van Vliet Patrick Piet , Puceat Michel , Andelfinger Gregor
Published: April 2022

The endocardium is a specialized form of endothelium that lines the inner side of the heart chambers and plays a crucial role in cardiac development. While comparatively less studied than other cardiac cell types, much progress has been made in understanding the regulation of and by the endocardium over the past two decades. In this review, we will summarize what is currently known regarding endocardial origin and development, the relationship between endocardium and other cardiac cell types, and the various lineages that endocardial cells derive from and contribute to. These processes are driven by key molecular mechanisms such as Notch and BMP signaling. These pathways in particular have been well studied, but other signaling pathways and mechanical cues also play important roles. Finally, we will touch on the contribution of stem cell modeling in combination with single cell sequencing and its potential translational impact for congenital heart defects such as bicuspid aortic valves and hypoplastic left heart syndrome. The detailed understanding of cellular and molecular processes in the endocardium will be vital to further develop representative stem cell-derived models for disease modeling and regenerative medicine in the future.
Medium- to Long-Term Outcomes after Reverse Total Shoulder Arthroplasty with a Standard Long Stem
Authors: Bülhoff Matthias , Zeifang Felix , Welters Caroline , Renkawitz Tobias , Schiltenwolf Marcus , Tross Anna-K.
Published: April 2022

Background: Long-term clinical and radiographic outcome data after standard cemented long-stem reverse shoulder arthroplasty (RSA) remain underreported. The aim of this study is to report on medium- to long-term data of patients over 60 years of age. Methods: The same type of RSA (Aequalis Reverse II, Memphis, TN, USA) was implanted in 27 patients with a mean age of 73 years (range 61–84). Indications for RSA were cuff tear arthropathy (CTA) in 25 cases and osteoarthritis (OA) in two cases. Pre- and postoperative Constant Score was assessed and component loosening, polyethylene wear, scapular notching and revision rates were recorded at a mean clinical follow-up (FU) of 127.6 months (SD ± 33.7; range 83–185). Results: The mean-adjusted CS (aCS) improved from 30.0 (range 10–59) to 95.0 (range 33–141) points (p < 0.001). Glenoid loosening was found in two (9.1%) and stem loosening was found in three (13.6%) cases. Polyethylene wear was observed in four (18.2%) cases. Scapular notching appeared in 15 (68.2%) cases but was not associated with poor aCS (p = 0.423), high levels of pain (p = 0.798) or external rotation (p = 0.229). Revision surgery was necessary in three (11.1%) cases. Conclusions: RSA with a cemented standard long stem leads to improvement in forward elevation, abduction and pain after a mean FU of 10 years. However, external rotation does not improve with this prosthetic design. Moreover, scapular notching is observed in the majority of cases, and revision rates (11.1%) as well as humeral loosening rates (13.6%) remain a concern. Level of evidence: Level 4, retrospective cohort study.
Increased Risk to Develop Hypertension and Carotid Plaques in Patients with Long-Lasting Helicobacter pylori Gastritis
Authors: Dore Maria Pina , Saba Pier Sergio , Tomassini Giulia , Niolu Caterina , Monaco Marco , Pes Giovanni Mario
Published: April 2022

Helicobacter pylori infection has been reported to be positively associated with hypertension, although with conflicting results. In this study, the relationship between H. pylori infection and hypertension, as well as atherosclerotic carotid lesions, was analyzed. Methods. Clinical records of patients referred to undergo upper endoscopy and gastric biopsy were retrieved. Information regarding the presence of H. pylori infection with atrophy/metaplasia/dysplasia (interpreted as a long-lasting infection), and current or past H. pylori infection was collected, as well as demographic variables, smoking habits, body mass index (BMI), dyslipidemia, diabetes, hypertension, presence of carotid lesions, and current treatment, and analyzed by multivariable regression models. Results. A total of 7152 clinical records from patients older than 30 years (63.4% women) were available for the study. Hypertension was present in 2039 (28.5%) patients and the risk was significantly increased in those with long-lasting H. pylori infection after adjusting for age decades, sex, BMI, cigarette smoking, diabetes, and dyslipidemia (OR 1.17, 95% CI 1.02–1.35). In addition, the long-lasting H. pylori infection was an independent risk for carotid plaques (OR 2.15, 95% CI 1.14–4.09). Conclusions. Our retrospective study demonstrated that long-lasting H. pylori infection is an independent risk factor for hypertension and the presence of carotid lesions after adjusting for potential confounders, although further validation our findings is needed from prospective studies.
Seasonal Variability of Near-Inertial Internal Waves in the Deep Central Part of the Black Sea
Authors: Khimchenko Elizaveta , Ostrovskii Alexander , Klyuvitkin Alexey , Piterbarg Leonid
Published: April 2022

This observational study is concerned with the seasonal variability of near-inertial internal waves (NIWs) in the central part of the Black Sea. Rotary spectral analysis of the nearly year-long time series of the sea current velocity measurements at 100 m and 1700 m revealed the prevailing anticyclonic component of the motions near the local inertial frequency f. Both the rotary spectra and the visual exploration of the time series showed that the peaks of NIWs were blue-shifted to higher frequencies. The monthly average blue-shift was stronger up to 1.038f in the summer. It was found that the minimum intensification of the NIWs occurred in summertime and the maximum intensification was characteristic of the autumn-winter period when the NIW packets included up to 16 waves with pronounced clockwise rotation of the velocity vectors.
Applying EDTA in Chelating Excess Metal Ions to Improve Downstream DNA Recovery from Mine Tailings for Long-Read Amplicon Sequencing of Acidophilic Fungi Communities
Authors: Nkuna Rosina , Ijoma Grace N. , Matambo Tonderayi S.
Published: April 2022

The hostile environment of mine tailings contains unique microbial life capable of bioleaching. The metagenomic analysis of such an environment provides an in-depth understanding of the microbial life and its potential, especially in biomining operations. However, DNA recovery from samples collected in those environments is challenging due to the presence of metal ions that interfere with the DNA analysis. A varied concentration of EDTA (4–13 µg/µL) to chelate the metal ions of enriched tailing samples prior to DNA extraction was performed. The results show that 9 µg/µL of EDTA was effective in most samples. However, the increasing concentration of EDTA negatively affected the DNA recovery. The sequencing of the successfully extracted DNA revealed a diverse range of fungal genera, some of which have not been previously reported in tailing or bioleaching applications. The dominant genera include Fodinomyces, Penicillium, Recurvomuces, Trichoderma, and Xenoacremonium; their traits were determined using the FungalTraits database. This study demonstrates the need to include a preliminary metal-chelating step using EDTA before DNA extractions for samples collected from metal-rich environments. It further showed the need for optimization but provided a benchmark range, particularly for tailings. However, we caution that a further EDTA removal step from the extracted DNA should be included to avoid its interferences in downstream applications.
Safety-Promoting Interventions for the Older Person with Hip Fracture on Returning Home: A Protocol for a Systematic Review
Authors: Rocha Paula , Baixinho Cristina Lavareda , Marques Andréa , Henriques Adriana
Published: April 2022

Ageing and physical frailty associated with decrease in muscle and bone mass lead to the older persons’ vulnerability and increased risk of falling. It is estimated that one in every ten falls in this age group results in a fracture, leading to a downward spiral in their health status, causing greater dependence, with a progressive functional decline that makes it difficult to return to their functional and social status prior to the fracture. The aim of this study is to identify the available evidence on the interventions that promote the safety of older people with hip fracture after hospital discharge. A search will be performed in MEDLINE and CINAHL databases. Randomised and controlled studies that focus on functional assessment, performance in activities of daily living, level of concern about falls, risk and prevalence of falls, injuries secondary to falls, re-fracture rate and health-related quality of life in hip fracture patients will be included. Two authors will perform the study selection, data extraction, and quality assessment independently. Any disagreements will be resolved through discussion with a third researcher. Methodological quality of the included trials will be evaluated by the Cochrane risk-of-bias criteria, and the Standards for Reporting Interventions in Controlled Trials.
Investigation of Molecular Features Involved in Clinical Responses and Survival in Advanced Endometrial Carcinoma Treated by Hormone Therapy
Authors: Neron Mathias , Guille Arnaud , Allegre Lucie , Colombo Pierre-Emmanuel , Leaha Cristina , Adelaide José , Carbuccia Nadine , Courtier Frédéric , Boissiere Florence , Crapez Evelyne , Fabbro Michel , Gouy Sébastien , Mamessier Emilie , Lambaudie Éric , Birnbaum Daniel , Bertucci François , Chaffanet Max
Published: April 2022

Hormone therapy (HT) is an effective treatment for metastatic endometrial carcinoma (mEC), with limited toxicity and low cost. We focused on molecular analysis of mECs treated by HT and, for the first time to date, we compared the genomic profiles of paired metastasis and primary ECs. The main objective was to identify predictive factors of the response to HT as well as specific altered signaling pathways driving mEC biology. From 1052 patients with EC treated by HT in two French cancer centers, 32 with endometrioid EC and 6 with high grade serous EC were included. We evaluated hormone receptors (HR) and mismatch repair proteins expression by immunohistochemistry and gene alterations by targeted next-generation sequencing and array-based comparative genomic hybridization. Several variables were tested in univariate and multivariate analyses to identify potential associations with (i) the clinical benefit of HT (CBHT) and (ii) a longer response (>18 months) (LRHT) and overall survival (OS). We compared the biological and genomic profiles of 11 primary/metastatic EC pairs. Thirty tumors (78.9%) were HR-positive and 6 (15.8%) showed microsatellite instability (MSI). The genomic profiles of 34 tumors showed an average altered genome of 3.26%, DNA repair homologous recombination deficiency in five tumors (14.7%), and 17 regions significantly targeted by amplification/deletion. Thirty-three tumors had 273 variants (158 genes, median of 7 mutations/sample), including 112 driver mutations. TP53, PTEN, PPP2R1A, ARID1A, FGFR2, and PIK3CA were the most frequently mutated. Based on the genomic status, nine oncogenic pathways were altered in more than 25% of primary EC. Clinically, 22 (57.9%) and 6 (15.8%) patients presented CBHT and LRHT, respectively. Neither oncogenic pathways alterations nor the variables tested were associated with CBHT and LRHT. Only patient’s age, mitotic index and the presence of at least one HR were associated with OS. Paired analysis of the primary/metastatic samples showed that among the 22 mutations acquired in the metastatic counterparts, the most frequently targeted genes were involved in pathways that might confer a selective advantage to cancer metastasis including hormone resistance. In conclusion, only patient’s age, mitotic index and the presence of at least one HR were associated with OS. The identification of gene mutations newly acquired in metastasis might help to better understand the formation of EC metastasis and select the best actionable candidates for HT-treated patients at the metastatic stage.
Privacy and Trust in eHealth: A Fuzzy Linguistic Solution for Calculating the Merit of Service
Authors: Ruotsalainen Pekka , Blobel Bernd , Pohjolainen Seppo
Published: April 2022

The use of eHealth and healthcare services are becoming increasingly common across networks and ecosystems. Identifying the quality and health impact of these services is a big problem that in many cases it is difficult determine. Health ecosystems are seldom designed with privacy and trust in mind, and the service user has almost no way of knowing how much trust to place in the service provider and other stakeholders using his or her personal health information (PHI). In addition, the service user cannot rely on privacy laws, and the ecosystem is not a trustworthy system. This demonstrates that, in real life, the user does not have significant privacy. Therefore, before starting to use eHealth services and subsequently disclosing personal health information (PHI), the user would benefit from tools to measure the level of privacy and trust the ecosystem can offer. For this purpose, the authors developed a solution that enables the service user to calculate a Merit of Service (Fuzzy attractiveness rating (FAR)) for the service provider and for the network where PHI is processed. A conceptual model for an eHealth ecosystem was developed. With the help of heuristic methods and system and literature analysis, a novel proposal to identify trust and privacy attributes focused on eHealth was developed. The FAR value is a combination of the service network’s privacy and trust features, and the expected health impact of the service. The computational Fuzzy linguistic method was used to calculate the FAR. For user friendliness, the Fuzzy value of Merit was transformed into a linguistic Fuzzy label. Finally, an illustrative example of FAR calculation is presented.