bluuebunny/crossref_metadata_2025 huggingface dataset:
HIV Self-Testing Uptake and Intervention Strategies Among Men in Sub-Saharan Africa: A Systematic Review
Authors: Hamilton Akeen , Thompson Noah , Choko Augustine T. , Hlongwa Mbuzeleni , Jolly Pauline , Korte Jeffrey E. , Conserve Donaldson F.
Published: February 2021

Background: HIV testing is an essential gateway to HIV prevention and treatment services. However, HIV testing uptake remains low among men due to stigma, discrimination, and confidentiality concerns. HIV self-testing (HIVST) is an alternative HIV testing method that can address many of these barriers for men. We conducted a systematic review to examine HIVST uptake and intervention strategies among Men in Sub-Saharan Africa.

Methods: We used a systematic approach to survey literature published from January 2010 to June 2020 using five electronic databases (PubMed-Medline, CINAHL Complete, PsychINFO, Google Scholar, and Web of Science) and a manual search. Studies were included if they were peer-reviewed, published in English, and examined HIVST willingness, uptake, and/or linkage to care and included men in Sub-Saharan Africa.

Results: Sixty-three articles related to HIVST were reviewed. Of the included articles, 37 discussed HIVST uptake/acceptability and 24 discussed intervention strategies. Both oral swab and finger-prick methods had high acceptability with ease of access and availability of the test cited as important by men. Free HIVST kits were preferred by men. Secondary distribution of kits via peers, sexual partners, and female sex workers were successful.

Conclusion: HIV self-testing is highly acceptable to men. More efforts are needed to develop policies to implement HIVST programs targeting men in Sub-Saharan Africa, including a focus on linkage to care in sub-Saharan Africa. Future interventions should directly target men independently in tandem with using peers and their romantic partners to promote self-testing among men in sub-Saharan Africa. HIVST kit distribution strategies should be combined with services that can offer confirmatory tests and counseling for men as well as linkage to care.
A Plan-Do-Study-Act Approach to the Development, Implementation and Evaluation of a Patient Navigation Program to Reduce Breast Cancer Screening Disparities in Un- and Under-Insured, Racially and Ethnically Diverse Urban Women
Authors: Guerra Carmen E. , Verderame Emily , Nicholson Andrea , Wan LiYea , Brooks Ari D.
Published: February 2021

Introduction: For the over 28 million Americans without health insurance, there is a great need to develop programs that help meet the health needs of the uninsured population.

Materials and Methods: We applied the Plan-Do-Study-Act (PDSA) quality improvement framework to the development, implementation, and evaluation of a breast cancer screening navigation program for un- and under-insured women.

Results: Six critical steps emerged: (1) obtain program funding; (2) navigator training; (3) establish a referral base network of community partners that serve the un- and under-insured women; (4) implement a process to address the barriers to accessing mammography; (5) develop a language- and culturally-tailored messaging and media campaign; and (6) develop measures and process evaluation to optimize and expand the program's reach.

Discussion: A Plan-Do-Study-Act approach allowed identification of the key elements for successful development, implementation and optimization of a breast cancer screening navigation program aimed at reaching and screening un- and underinsured women.
How Successful Is Surgical Sperm Retrieval in Klinefelter Syndrome?
Authors: Kailash Yamini , Raheem Amr Abdel , Homa Sheryl T.
Published: February 2021

Klinefelter Syndrome (KS) is characterized by the presence of an extra X chromosome. It was first diagnosed in 1942 in a group of azoospermic men. KS is the most common chromosomal abnormality encountered in infertile men and accounts for more than 10% of the causes of azoospermia. Men who are azoospermic may still father children via testicular sperm extraction followed by intracytoplasmic sperm injection (ICSI). This review article summarizes the success rates of the available techniques for surgical sperm retrieval (SSR) in KS including conventional testicular sperm extraction (cTESE) and micro testicular sperm extraction (mTESE), as well as the risks of these procedures for future fertility. The evidence indicates that the SSR rate is as successful in non-mosaic men with KS as those with normal karyotypes, with retrieval rates of up to 55% reported. The influence of different factors that affect the chances of a successful outcome are discussed. In particular, the impact of aneuploidy rate, physical characteristics, co-morbidities, reproductive endocrine balance and the use of different hormone management therapies are highlighted. Evidence is presented to suggest that the single most significant determinant for successful SSR is the age of the patient. The success of SSR is also influenced by surgical technique and operative time, as well as the skills of the surgeon and embryology team. Rescue mTESE may be used successfully following failed TESE in KS patients in combination with hormone stimulation.
Psychological Profile and Competitive Performance in Group Aesthetic Gymnastics
Authors: Armada Martínez Celia , Cavas-García Francisco , Díaz-Suárez Arturo , Martínez-Moreno Alfonso
Published: February 2021

The objective of the research was to evaluate the perceptions about the psychological variables of cohesion and motivational climate that AGG gymnasts have about the context created by the coaches in their teams and to analyze in the different categories the optimism and competitive anxiety they face in competitive situations. In an attempt to clarify the psychosocial training patterns in this sport and the influence they have on the well-being of its practitioners, competitive anxiety, motivational climate, team cohesion and level of optimism were taken as dependent variables. The sample was made up of 98 national and international junior and senior athletes in the aesthetic gymnastics group aged 13 to 27 (M = 17.1; SD = 2.8). The Perceived Motivational Climate in Sport Questionnaire for motivational climate, the Sport Anxiety Scale-2 for competitive anxiety, the Group Environment Questionnaire for cohesion and the Revised Life Orientation Test for optimism were used in the evaluation. The results obtained show a positive and statistically significant correlation between anxiety and ego involvement, while, for task involvement, high levels of cohesion are associated with high levels of optimism (p= 0.005). In conclusion, the data confirm that high levels of cohesion are associated with high levels of optimism, in addition high scores on task involvement show high scores on cohesion and optimism, however high scores on ego involvement are associated with low scores on cohesion and optimism.
Talent Identification and Relative Age Effects in English Male Rugby Union Pathways: From Entry to Expertise
Authors: Kelly Adam L. , Till Kevin , Jackson Daniel , Barrell Donald , Burke Kate , Turnnidge Jennifer
Published: February 2021

A common practice in youth rugby union is to group players based on (bi)annual age with fixed cut-off dates. The overrepresentation of players born at the start of the cut-off date and the underrepresentation of players born toward the end of the cut-off date are termed relative age effects (RAEs). The aim of this study was to examine RAEs during entry into professional and international rugby union pathways in England, as well as comparing them to their respective senior cohort: U15 Regional Academy Player (n = 1,114) vs. Senior Professional Player (n = 281) and U16–23 England Academy Player (n = 849) vs. Senior International Player (n = 48). Chi-square (χ2) analysis compared birth quarter (BQ) distributions against expected distributions. Odds ratios and 95% confidence intervals compared the likelihood of a BQ being selected. Findings revealed a significant overrepresentation of relatively older players compared with their relatively younger peers within both youth cohorts (P < 0.001; BQ1 = 42.5% vs. BQ4 = 9.6%; BQ1 = 36.5% vs. BQ4 = 15.2%). In comparison, there was no significant difference in the BQ distributions within both senior cohorts. Further, BQ4s were 3.86 and 3.9 times more likely to achieve senior professional and international levels than BQ1s and BQ2s, respectively. It is suggested that relatively younger players may have a greater likelihood of achieving expertise following entry into a rugby union talent pathway due to benefitting from more competitive play against relatively older counterparts during their development (e.g., reversal effects; the underdog hypothesis). Moreover, possible solutions (e.g., age and anthropometric banding; playing-up and playing-down) are discussed to encourage practitioners and policy makers to create the most appropriate learning environment for every player.
Surface Electromyography Spectral Parameters for the Study of Muscle Fatigue in Swimming
Authors: Puce Luca , Pallecchi Ilaria , Marinelli Lucio , Mori Laura , Bove Marco , Diotti Daniele , Ruggeri Piero , Faelli Emanuela , Cotellessa Filippo , Trompetto Carlo
Published: February 2021

The purpose of this study was to assess validity, stability and sensitivity, of 4 spectral parameters–median frequency (Fmed), mean frequency (Fmean), Dimitrov index (DI), and mean instant frequency (Fmi)–in measuring localized muscle fatigue in swimming and to investigate their correlation with the variations of kinematic data and mechanical fatigue. Electrophysiological measures of muscle fatigue were obtained in real-time during a 100 m front crawl test at maximum speed in 15 experienced swimmers, using surface electromyography in six muscles employed in front crawl, while kinematic data of swimming was measured from video analysis. Mechanical fatigue was measured as the difference between muscle strength prior to and immediately after the 100 m front crawl in a dry-land multi-stage isometric contraction test. Statistically significant fatigue (p < 0.0001) was found for all spectral parameters in all muscles. Fmed and Fmean varied between 10 and 25%, DI between 50 and 150%, and Fmi between 5 and 10%. Strong correlation (Pearson r ≥ 0.5) with mechanical fatigue was found for all spectral parameters except for Fmi and it was strongest for Fmed and Fmean. From our study, it turns out that Fmed and Fmean are more valid and stable parameters to measure fatigue in swimming, while DI is more sensitive.
Conceptualizing Responsibility in Food Research and Innovation to Promote Healthy and Sustainable Food Systems
Authors: Timotijevic Lada , Hodgkins Charo Elena , Peacock Matthew , Raats Monique Maria
Published: February 2021

Responsibility is crucial to governance and key to achieving legitimacy within complex systems, yet there is limited attention to how it should be conceptualized within the context of food research and innovation (R&I). Understanding how diverse stakeholders in food R&I conceptualize responsibility is vital because it shapes the way problems are identified, goals are set and solutions are put in place. We report on empirical research with diverse stakeholders across Europe to understand and map the dimensions of responsibility for food R&I to support healthy and sustainable food systems. Semi-structured interviews were conducted with 32 stakeholders working in R&I in the cutting-edge domains of: cultured meat as a substitute for livestock meat; new crop breeding of potatoes; and a new approach to obesity reduction that focuses on weight acceptance. Drawing from the empirical evidence collected, we developed a classification system that reflects various conceptualizations of stakeholders' responsibility for food R&I to support healthy and sustainable food systems. Our thematic analysis revealed four overlapping rationales of responsibility—accountability, impact, reflexivity, and responsiveness, and characterized them in terms of: who the researcher is responsible to; whether the assessments of responsibility focus on R&I processes or impact; whether responsibility implies societal engagement; and how responsibility is assessed—retrospectively or prospectively. The article provides a basis for systematic application of these criteria to the specific instances of food R&I governance and for future joint decisions, about the ways to allocate responsibilities.
Dismantling of Institutionalization and State Policies as Guarantors of Food Security in Venezuela: Food Safety Implications
Authors: Hernández Pablo , Carmona Andrés , Tapia Maria S. , Rivas Siloyde
Published: February 2021

Historically, Venezuela was recognized as a country with solid government food safety policies, science-based legislation, clear national food security goals, strict standards for domestic food production and imports, and a system of institutions committed to ensuring safety and quality along each step of the food chain. Major institutions that aimed to insure people's welfare, nutrition and food availability, and safety were created between 1936 and 1949. Remarkable progress was achieved in terms of control of tropical maladies and fight against hunger and malnutrition. The National Institute of Hygiene set the standards for food safety and the continuous surveillance of available foods. The National Codex Alimentarius Committee was officially created in 2001. Nowadays, the situation has dramatically deteriorated as indicated by a severe decline of national food production and a strong dependence on food imports, whose prices make them inaccessible to the majority of Venezuelans. In response to the humanitarian crisis, the government created a food program, the so-called Local Supply and Production Committee (CLAP), to distribute basic foods at reduced prices but with clear intentions of social and political control of the population. Currently, CLAP products come from government imports at a preferential exchange rate. Under the umbrella of an economic emergency decree, many food safety regulations and surveillance protocols have been relaxed or eliminated, often resulting in the acquisition of low-quality items that do not meet Venezuelan food preferences or quality standards. The objective of this work is to describe, through the Venezuelan case, how the food security infrastructure of a country can be dismantled. We address (1) the development of institutions dedicated to promoting food security and nutrition and the recent dismantling of the sector; (2) the creation, characteristics, and weakness of the CLAP program; and (3) the current food insecurity crisis and the attempts to provide humanitarian help to the Venezuelan population.
Ecosystem Services and Cash Crop Tradeoffs of Summer Cover Crops in Northern Region Organic Vegetable Rotations
Authors: Wauters Vivian M. , Grossman Julie M. , Pfeiffer Anne , Cala Rodrigo
Published: February 2021

Intensive production practices characterizing vegetable farming contribute to high productivity, but often at the expense of supporting and regulating ecosystem services. Diversification with cover crops may support increased resilience through soil organic matter (SOM) contributions and physical soil protection. Vegetable farming often includes spring and fall production, limiting establishment and productive potential of over-wintered cover crops that are more widely used in the USA. In northern climate vegetable systems, warm-season cover crops planted during short summer fallows could be a tool to build resilience via ecosystem service enhancement. This project evaluated summer cover crops in the northern USA (MN and WI) for biomass accumulation, weed suppression, and contribution to fall cash crop yield. Our study included four site years, during which we investigated the effects of four cover crop species treatments, grown for 30 (short duration, SD) or 50 days (long duration, LD) alongside bare fertilized and unfertilized control treatments: buckwheat (Fagopyrum esculentum) and sunn hemp (Crotalaria juncea) monocultures, and biculture of chickling vetch (Lathyrus sativus) or cowpea (Vigna unguiculata) with sorghum-sudangrass (sudex) (Sorghum bicolor x S. bicolor var. Sudanese). To quantify cover crop quantity, quality, and weed suppression capacity, we measured cover crop and weed biomass, and biomass C:N. To quantify effects on cash crops, we measured fall broccoli yield and biomass. Mean total biomass (cover crop + weeds) by site year ranged from 1,890 kg ha−1 in MN Y1 to 5,793 kg ha−1 in WI Y2 and varied among species in Y1 for both the SD and LD treatments. Most cover crops did not outcompete weeds, but treatments with less weeds produced more overall biomass. Data from Y1 show that cover crops were unable to replace fertilizer for fall broccoli yield, and led to reduced fall crop yield. Broccoli in Y2 did not reach maturity due to fall freeze. Summer cover crops, because of their biomass accumulation potential, may be used by farmers in northern climates to fit into cropping system niches that have historically been left as bare soil, but care with timing is necessary to optimize weed suppression and mitigate tradeoffs for cash crop production.
The Challenges of 21st Century Neurotoxicology: The Case of Neurotoxicology Applied to Nanomaterials
Authors: Bencsik Anna , Lestaevel Philippe
Published: February 2021

After a short background discussing engineered nanomaterials (ENMs) and their physicochemical properties and applications, the present perspective paper highlights the main specific points that need to be considered when examining the question of neurotoxicity of nanomaterials. It underlines the necessity to integrate parameters, specific tools, and tests from multiple sources that make neurotoxicology when applied to nanomaterials particularly complex. Bringing together the knowledge of multiple disciplines e.g., nanotoxicology to neurotoxicology, is necessary to build integrated neurotoxicology for the third decade of the 21st Century. This article focuses on the greatest challenges and opportunities offered by this specific field. It highlights the scientific, methodological, political, regulatory, and educational issues. Scientific and methodological challenges include the determination of ENMs physicochemical parameters, the lack of information about protein corona modes of action, target organs, and cells and dose– response functions of ENMs. The need of standardization of data collection and harmonization of dedicated neurotoxicological protocols are also addressed. This article highlights how to address those challenges through innovative methods and tools, and our work also ventures to sketch the first list of substances that should be urgently prioritized for human modern neurotoxicology. Finally, political support with dedicated funding at the national and international levels must also be used to engage the communities concerned to set up dedicated educational program on this novel field.
O funkcjach hasztagu na Twitterze
Authors: Sobczak Barbara
Published: February 2021

communication on Twitter. The analysis covered their structure as well as
pragmatic and rhetoric functions. As a result, it can be said that hashtags are
not only applied on Twitter as a simple categorisation method but also created
by Twitter users for the purpose of disseminating information, commenting,
expressing views, promoting brands, supporting events, seeking information,
and building virtual communities of people interested in specifi c topics. When
considering their reach, in turn, it might be concluded that hashtags are more
effective as acts of informing, commenting, prizing, criticising, expressing
emotions, etc. on the Internet than untagged words and expressions.
Językowe sposoby wyrażania ekspresji. Tomasz Raczek o dziennikarzach
Authors: Majewska Magdalena
Published: February 2021

In the first part of the text entitled Linguistic methods of expressing emotions.
Tomasz Raczek about journalist, the author presents Tomasz Raczek’s writing, in
particular his feature articles, where the columnist refers to the contemporary
social life from the perspective of film and television criticism.
In the subsequent parts of the text, the author describes selected
components of the history of feature articles and presents some definitions
of a feature article, and then focuses on the linguistic aspects of a subjective
way of expressing the emotions and feelings accompanying the description of
mass media personalities. The author pays a special attention to the techniques
used by Raczek, for example putting things very close together in order to show
a contrast, using metaphors and anglicisms to describe media personalities.
In the last part of the text, the author juxtaposes the previously described
techniques of the columnist, sums up the discussions on the linguistic methods
of expressing emotions and feelings in Tomasz Raczek’s feature articles.
EU diplomacy 2.0: The European Union’s exercise in soft power in the Philippines through Facebook
Authors: Enverga Manuel
Published: February 2021

Digital diplomacy, also referred to as e-Diplomacy or Diplomacy 2.0, is a form of public diplomacy that entails the pursuance of foreign policy objectives using the Internet and social media. It is one of the ways that actors in contemporary global politics can exert soft power, thereby shaping a host country’s perceptions, agendas, and policies. The increasing use of digital diplomacy exemplifies a shift in diplomatic from purely government-to-government (G2G) relations, to one in which communication is directed towards publics (G2P), and can even encourage citizens to interact with one another (P2P). One actor that has become increasingly active in this area is the European Union (EU). However, unlike a country, the regional bloc is a coalition of twenty-eight member states. Consequently, the challenge for EU digital diplomacy specialists is to represent a group of countries to local audiences. There is minimal literature on this subject, and this paper hopes to contribute to it by presenting a case study of the EU’s digital diplomacy initiatives towards Philippines, which are communicated through the popular social networking website, Facebook. This paper argues that the EU exercises its soft power through its social media transmissions it creates. The individuals featured in its online content, the way that the European Union represents itself, and the issues it highlights in its posts are all geared towards shaping the perceptions of Philippine audiences.
Vapor Phosphorylation of Cellulose by Phosphorus Trichlo-Ride: Selective Phosphorylation of 6-Hydroxyl Function—The Synthesis of New Antimicrobial Cellulose 6-Phosphate(III)-Copper Complexes
Authors: Kudzin Marcin H. , Mrozińska Zdzisława , Urbaniak Paweł
Published: February 2021

This research is focused on a synthesis of copper-cellulose phosphates antimicrobial complexes. Vapor-phase phosphorylations of cellulose were achieved by exposing microcrystalline cellulose to phosphorus trichloride (PCl3) vapors. The cellulose-O-dichlorophosphines (Cell-O-PCl2) formed were hydrolyzed to cellulose-O-hydrogenphosphate (P(III)) (Cell-O-P(O)(H)(OH)), which, in turn, were converted into corresponding copper(II) complexes (Cell-O-P(O)(H)(OH)∙Cu2+). The analysis of the complexes Cell-O-P(O)(H)(OH)∙Cu2+ covered: scanning electron microscopy (SEM), attenuated total reflection Fourier transform infrared spectroscopy (ATR-FTIR), atomic absorption spectrometry with flame excitation (FAAS), and bioactivity tests against representative Gram-negative bacteria (Escherichia coli) and Gram-positive bacteria (Staphylococcus aureus). The antimicrobial tests of synthesized Cell-O-P(O)(H)(OH)∙Cu2+ revealed their potential applications as an antibacterial material.
Activity of Imipenem, Meropenem, Cefepime, and Sulbactam in Combination with the β-Lactamase Inhibitor LN-1-255 against Acinetobacter spp.
Authors: Lasarte-Monterrubio Cristina , Vázquez-Ucha Juan C. , Maneiro Maria , Arca-Suárez Jorge , Alonso Isaac , Guijarro-Sánchez Paula , Buynak John D. , Bou Germán , González-Bello Concepción , Beceiro Alejandro
Published: February 2021

Treatment of infections caused by Acinetobacter spp., particularly A. baumannii, is a major clinical problem due to its high rates of antibiotic resistance. New strategies must be developed; therefore, restoration of β-lactam efficacy through the use of β-lactamase inhibitors is paramount. Activities of the antibiotics imipenem, meropenem, cefepime, and sulbactam in combination with the penicillin-sulfone inhibitor LN-1-255 were tested by microdilution against 148 isolates of Acinetobacter spp. collected in 14 hospitals in Spain in 2020. Relevantly, the MIC90 (i.e., minimum concentration at which 90% of isolates were inhibited) of antibiotics in combination with LN-1-255 decreased 4- to 8-fold for all of the Acinetobacter isolates. Considering only the carbapenem-resistant A. baumannii isolates, which produce carbapenem-hydrolyzing class D β-lactamases, the addition of LN-1-255 decreased the resistance rates from 95.1% to 0% for imipenem, from 100% to 9.8% for meropenem, from 70.7% to 7.3% for cefepime, and sulbactam resistance rates from 9.8% to 0% and intermediate susceptibility rates from 53.7% to 2.4%. The inhibitor also decreased the minimum inhibitory concentrations (MICs) when tested against non-carbapenem-resistant Acinetobacter spp. isolates. In conclusion, combining LN-1-255 with imipenem, meropenem, cefepime, and sulbactam to target A. baumannii, and especially carbapenem-resistant isolates, represents an attractive option that should be developed for the treatment of infections caused by this pathogen.
Systematic Review of Exposure to Bisphenol A Alternatives and Its Effects on Reproduction and Thyroid Endocrine System in Zebrafish
Authors: Lee Jiyun , Moon Kyong Whan , Ji Kyunghee
Published: February 2021

Bisphenol A (BPA), which is widely used for manufacturing polycarbonate plastics and epoxy resins, has been banned from use in plastic baby bottles because of concerns regarding endocrine disruption. Substances with similar chemical structures have been used as BPA alternatives; however, limited information is available on their toxic effects. In the present study, we reviewed the endocrine disrupting potential in the gonad and thyroid endocrine system in zebrafish after exposure to BPA and its alternatives (i.e., bisphenol AF, bisphenol C, bisphenol F, bisphenol S, bisphenol SIP, and bisphenol Z). Most BPA alternatives disturbed the endocrine system by altering the levels of genes and hormones involved in reproduction, development, and growth in zebrafish. Changes in gene expression related to steroidogenesis and sex hormone production were more prevalent in males than in females. Vitellogenin, an egg yolk precursor produced in females, was also detected in males, confirming that it could induce estrogenicity. Exposure to bisphenols in the parental generation induced a decrease in the hatchability associated with offspring generation. In zebrafish exposed to bisphenols, significant decreases in thyroxine concentrations and increases in thyroid-stimulating hormone concentrations were commonly observed. Alternative compounds used to replace a chemical of concern are believed to be less toxic than the original compound; however, several BPA alternatives appear to have similar or greater effects on the endocrine system in zebrafish. Since endocrine systems interact with each other, further studies are needed to assess the primary target of BPA alternatives among the endocrine axes.
The Incorporation of Steel Slag into Belite-Sulfoaluminate Cement Clinkers
Authors: Žibret Lea , Šter Katarina , Borštnar Maruša , Loncnar Mojca , Dolenec Sabina
Published: February 2021

The potential use of steel slag from treated steel slag in belite-sulfoaluminate cements was investigated in this study. Cement clinkers with two phase compositions were synthesized, allowing the incorporation of different amounts of steel slag. The phase composition and microstructure of cement clinkers at three different sintering temperatures were studied by X-ray powder diffraction and the Rietveld method, as well as scanning electron microscopy with energy dispersive spectrometry. The results showed that the targeted phase composition of clinkers was achieved at a sintering temperature of 1250 °C. However, a higher amount of perovskite instead of ferrite was detected in the clinker with a higher content of Ti-bearing bauxite. Apart from the main phases, such as belite, calcium sulfoaluminate, and ferrite, several minor phases were identified, including mayenite, perovskite, periclase, and alkali sulfates. In both clinker mixtures, a higher content of MgO in the steel slags resulted in the formation of periclase. Furthermore, the hydration kinetics and compressive strength at 7 and 28 days were studied in two cements prepared from clinkers sintered at 1250 °C. As evidenced by the results of isothermal calorimetry, the hydration kinetics were also influenced by the minor clinker phases. Cement with a higher content of calcium sulfoaluminate phase developed a higher compressive strength.
Fast Thumbnail Extraction for H.264/AVC, HEVC and VP9
Authors: Byeon Joohyung , Jang Seungchul , Lee Jongseok , Kim Kyungyong , Sim Donggyu
Published: February 2021

In this paper, we propose a partial decoding method with limited memory usage for high-speed thumbnail extraction. The proposed method performs a partial inverse transform and a partial intra prediction in order to reconstruct pixels for intra prediction and thumbnails. Thereafter, the reconstructed pixels at the bottom and right line of the block are stored in the line buffer and the thumbnail buffer without being stored in the decoded picture buffer with full resolution. H.264/AVC, HEVC and VP9 video codecs have different coding structures, prediction and transforms; however, the proposed algorithm can be applied to the corresponding codecs in the same manner. In order to evaluate the performance of the proposed method, we implemented the proposed algorithm for H.264/AVC, HEVC and VP9. We found that the thumbnail extraction time of the proposed method decreased by 66% in H.264/AVC, 52% in HEVC and 48% in VP9 as compared to the full decoding method.
Mitigation against DDoS Attacks on an IoT-Based Production Line Using Machine Learning
Authors: Huraj Ladislav , Horak Tibor , Strelec Peter , Tanuska Pavol
Published: February 2021

Industry 4.0 collects, exchanges, and analyzes data during the production process to increase production efficiency. Internet of Things (IoT) devices are among the basic technologies used for this purpose. However, the integration of IoT technology into the industrial environment faces new security challenges that need to be addressed. This is also true for a production line. The production line is a basic element of industrial production and integrating IoT equipment allows one to streamline the production process and thus reduce costs. On the other hand, IoT integration opens the way for network cyberattacks. One possible cyberattack is the increasingly widely used distributed denial-of-service attack. This article presents a case study that demonstrates the devastating effects of a DDOS attack on a real IoT-based production line and the entire production process. The emphasis was mainly on the integration of IoT devices, which could potentially be misused to run DDoS. Next, the verification of the proposed solution is described, which proves that it is possible to use the sampled flow (sFlow) stream to detect and protect against DDoS attacks on the running production line during the production process.
Seismic Response of Flat Ground and Slope Models through 1 g Shaking Table Tests and Numerical Analysis
Authors: Jin Yong , Kim Hoyeon , Kim Daehyeon , Lee Yonghee , Kim Haksung
Published: February 2021

In order to verify the reliability of numerical analysis, a series of 1 g shaking table tests for flat ground and slope were conducted using a laminar shear box subjected to different seismic waves. Firstly, numerical analyses, using the DEEPSOIL and ABAQUS software, were done to compare the results of flat ground experiments. After that, finite element analyses with ABAQUS were conducted to compare the results of slope experiments. For numerical analyses, considering the influence of the boundary, the concept of adjusted elastic modulus was proposed to improve the simulation results. Based on the analyses, it is found that in terms of acceleration-time history and spectral acceleration, the numerical analysis results are in good agreement with the experiment results. This implies that numerical analysis can capture the dynamic behavior of soil under 1 g shaking table test conditions.
Statins Directly Influence the Polarization of Adipose Tissue Macrophages: A Role in Chronic Inflammation
Authors: Kauerova Sona , Bartuskova Hana , Muffova Barbora , Janousek Libor , Fronek Jiri , Petras Marek , Poledne Rudolf , Kralova Lesna Ivana
Published: February 2021

Statins represent one of the most widely used classes of drugs in current medicine. In addition to a substantial decrease in atherogenic low density lipoprotein (LDL) particle concentrations, several large trials have documented their potent anti-inflammatory activity. Based on our preliminary data, we showed that statins are able to decrease the proportion of pro-inflammatory macrophages (CD14+16+CD36high) in visceral adipose tissue in humans. In the present study including 118 healthy individuals (living kidney donors), a very close relationship between the pro-inflammatory macrophage proportion and LDL cholesterol levels was found. This was confirmed after adjustment for the most important risk factors. The effect of statins on the proportion of pro-inflammatory macrophages was also confirmed in an experimental model of the Prague hereditary hypercholesterolemia rat. A direct anti-inflammatory effect of fluvastatin on human macrophage polarization in vitro was documented. Based on modifying the LDL cholesterol concentrations, statins are suggested to decrease the cholesterol inflow through the lipid raft of macrophages in adipose tissue and hypercholesterolemia to enhance the pro-inflammatory macrophage phenotype polarization. On the contrary, due to their opposite effect, statins respond with anti-inflammatory activity, affecting the whole organism.
Reinforcement Learning for Radiotherapy Dose Fractioning Automation
Authors: Moreau Grégoire , François-Lavet Vincent , Desbordes Paul , Macq Benoît
Published: February 2021

External beam radiotherapy cancer treatment aims to deliver dose fractions to slowly destroy a tumor while avoiding severe side effects in surrounding healthy tissues. To automate the dose fraction schedules, this paper investigates how deep reinforcement learning approaches (based on deep Q network and deep deterministic policy gradient) can learn from a model of a mixture of tumor and healthy cells. A 2D tumor growth simulation is used to simulate radiation effects on tissues and thus training an agent to automatically optimize dose fractionation. Results show that initiating treatment with large dose per fraction, and then gradually reducing it, is preferred to the standard approach of using a constant dose per fraction.
Reclassification of Kidney Clear Cell Carcinoma Based on Immune Cell Gene-Related DNA CpG Pairs
Authors: Luo Qizhan , Vögeli Thomas-Alexander
Published: February 2021

Background: A new method was developed based on the relative ranking of gene expression level, overcoming the flaw of the batch effect, and having reliable results in various studies. In the current study, we defined the two methylation sites as a pair. The methylation level in a specific sample was subject to pairwise comparison to calculate a score for each CpGs-pair. The score was defined as a CpGs-pair score. If the first immune-related CpG value was higher than the second one in a specific CpGs-pair, the output score of this immune-related CpGs-pair was 1; otherwise, the output score was 0. This study aimed to construct a new classification of Kidney Clear Cell Carcinoma (KIRC) based on DNA CpGs (methylation sites) pairs. Methods: In this study, the biomarkers of 28 kinds of immune infiltration cells and corresponding methylation sites were acquired. The methylation data were compared between KIRC and normal tissue samples, and differentially methylated sites (DMSs) were obtained. Then, DNA CpGs-pairs were obtained according to the pairs of DMSs. In total, 441 DNA CpGs-pairs were utilized to construct a classification using unsupervised clustering analysis. We also analyzed the potential mechanism and therapy of different subtypes, and validated them in a testing set. Results: The classification of KIRC contained three subgroups. The clinicopathological features were different across three subgroups. The distribution of immune cells, immune checkpoints and immune-related mechanisms were significantly different across the three clusters. The mutation and copy number variation (CNV) were also different. The clinicopathological features and potential mechanism in the testing dataset were consistent with those in the training set. Conclusions: Our findings provide a new accurate and stable classification for developing personalized treatments for the new specific subtypes.
Beyond Reading Modulation: Temporo-Parietal tDCS Alters Visuo-Spatial Attention and Motion Perception in Dyslexia
Authors: Lazzaro Giulia , Bertoni Sara , Menghini Deny , Costanzo Floriana , Franceschini Sandro , Varuzza Cristiana , Ronconi Luca , Battisti Andrea , Gori Simone , Facoetti Andrea , Vicari Stefano
Published: February 2021

Dyslexia is a neurodevelopmental disorder with an atypical activation of posterior left-hemisphere brain reading networks (i.e., temporo-occipital and temporo-parietal regions) and multiple neuropsychological deficits. Transcranial direct current stimulation (tDCS) is a tool for manipulating neural activity and, in turn, neurocognitive processes. While studies have demonstrated the significant effects of tDCS on reading, neurocognitive changes beyond reading modulation have been poorly investigated. The present study aimed at examining whether tDCS on temporo-parietal regions affected not only reading, but also phonological skills, visuo-spatial working memory, visuo-spatial attention, and motion perception in a polarity-dependent way. In a within-subjects design, ten children and adolescents with dyslexia performed reading and neuropsychological tasks after 20 min of exposure to Left Anodal/Right Cathodal (LA/RC) and Right Anodal/Left Cathodal (RA/LC) tDCS. LA/RC tDCS compared to RA/LC tDCS improved text accuracy, word recognition speed, motion perception, and modified attentional focusing in our group of children and adolescents with dyslexia. Changes in text reading accuracy and word recognition speed—after LA/RC tDCS compared to RA/LC—were related to changes in motion perception and in visuo-spatial working memory, respectively. Our findings demonstrated that reading and domain-general neurocognitive functions in a group of children and adolescents with dyslexia change following tDCS and that they are polarity-dependent.
MicroRNAs: Their Role in Metastasis, Angiogenesis, and the Potential for Biomarker Utility in Bladder Carcinomas
Authors: Hammouz Raneem Y. , Kołat Damian , Kałuzińska Żaneta , Płuciennik Elżbieta , Bednarek Andrzej K.
Published: February 2021

Angiogenesis is the process of generating new capillaries from pre-existing blood vessels with a vital role in tumor growth and metastasis. MicroRNAs (miRNAs) are noncoding RNAs that exert post-transcriptional control of protein regulation. They participate in the development and progression of several cancers including bladder cancer (BLCA). In cancer tissue, changes in microRNA expression exhibit tissue specificity with high levels of stability and detectability. miRNAs are less vulnerable to degradation, making them novel targets for therapeutic approaches. A suitable means of targeting aberrant activated signal transduction pathways in carcinogenesis of BLCA is possibly through altering the expression of key miRNAs that regulate them, exerting a strong effect on signal transduction. Precaution must be taken, as the complexity of miRNA regulation might result in targeting several downstream tumor suppressors or oncogenes, enhancing the effect further. Since exosomes contain both mRNA and miRNA, they could therefore possibly be more effective in targeting a recipient cell if they deliver a specific miRNA to modify the recipient cell protein production and gene expression. In this review, we discuss the molecules that have been shown to play a significant role in BLCA tumor development. We also discuss the roles of various miRNAs in BLCA angiogenesis and metastasis. Advances in the management of metastatic BLCA have been limited; miRNA mimics and molecules targeted at miRNAs (anti-miRs) as well as exosomes could serve as therapeutic modalities or as diagnostic biomarkers.
Heterogeneous Response to Immunotherapy in a Patient with Tonsillar Squamous Cell Carcinoma Assessed by 18F-FDG PET/CT
Authors: Niccoli Asabella Artor , Nappi Anna Giulia , Trani Orsola , Sardaro Angela , Rubini Giuseppe
Published: February 2021

Tonsillar carcinoma is the second most common malignancy of the head and neck region, with Squamous Cell Carcinoma (TSCC) as the most common histological type (>90%). For the advanced stage of TSCC, radiotherapy with or without platinum-based chemotherapy is the only therapeutic option. Immuno-checkpoint inhibitors (ICIs), in particular Nivolumab, considerably improves clinical management of these patients, but the response can be unpredictable. Difficulties can be encountered in evaluating response to immunotherapy, especially with morphological imaging, which can show an atypical response, such as pseudo-progression, leading to a premature discontinuation. Conversely, metabolic imaging can guide a more properly therapeutic decision. We present a case of a 71-year-old man affected by TSCC, treated with chemotherapy, radiotherapy, and Nivolumab as the last line of treatment. Pre- and post-immunotherapy 18F-FDG PET/CT showed an impressive response, avoiding early drug discontinuation and ensuring better management of this patient.
Inhibition of Androgen Signalling Improves the Outcomes of Therapies for Bladder Cancer: Results from a Systematic Review of Preclinical and Clinical Evidence and Meta-Analysis of Clinical Studies
Authors: Creta Massimiliano , Celentano Giuseppe , Napolitano Luigi , La Rocca Roberto , Capece Marco , Califano Gianluigi , Collà Ruvolo Claudia , Mangiapia Francesco , Morra Simone , Turco Carmine , Spirito Lorenzo , Fusco Ferdinando , Imbimbo Ciro , Mirone Vincenzo , Longo Nicola
Published: February 2021

Bladder cancer (BCa) is an endocrine-related tumour and the activation of androgen signalling pathways may promote bladder tumorigenesis. We summarized the available preclinical and clinical evidence on the implications of the manipulation of androgen signalling pathways on the outcomes of BCa therapies. A systematic review was performed in December 2020. We included papers that met the following criteria: original preclinical and clinical research; evaluating the impact of androgen signalling modulation on the outcomes of BCa therapies. Six preclinical and eight clinical studies were identified. The preclinical evidence demonstrates that the modulation of androgen receptor-related pathways has the potential to interfere with the activity of the Bacillus Calmette Guerin, doxorubicin, cisplatin, gemcitabine, and radiotherapy. The relative risk of BCa recurrence after transurethral resection of the bladder tumour (TURBT) is significantly lower in patients undergoing therapy with 5 alpha reductase inhibitors (5-ARIs) or androgen deprivation therapy (ADT) (Relative risk: 0.50, 95% CI: 0.30–0.82; p = 0.006). Subgroup analysis in patients receiving 5-ARIs revealed a relative risk of BCa recurrence of 0.46 (95% CI: 0.22–0.95; p = 0.040). A significant negative association between the ratio of T1 BCa patients in treated/control groups and the relative risk of BCa recurrence was observed. Therapy with 5-ARIs may represent a potential strategy aimed at reducing BCa recurrence rate, mainly in patients with low stage disease. Further studies are needed to confirm these preliminary data.
Electric Vehicles Ready for Breakthrough in MaaS? Consumer Adoption of E-Car Sharing and E-Scooter Sharing as a Part of Mobility-as-a-Service (MaaS)
Authors: Brezovec Paula , Hampl Nina
Published: February 2021

Current mobility trends indicate that the popularity of privately-owned cars will decrease in the near future. One reason for this development is the diffusion of mobility services such as car or bike sharing, or Mobility-as-a-Service (MaaS) bundles. Especially, MaaS bundles have the potential to respond to environmental issues and provide reliable mobility to users, thus illustrating the possibilities of being mobile without owning a car. Most of the past research on MaaS bundles, however, has focused on bigger cities that already have good infrastructural bases. Building on previous work in the MaaS field, we conducted a choice-based conjoint survey (n = 247) in Austria to investigate consumer preferences for MaaS packages in a suburban area. Further, we gathered data on the consumers’ willingness to pay, especially for including electric vehicles in the form of e-car sharing and e-scooter sharing in MaaS packages. The results highlight the importance of package price as the attribute with the highest impact on purchase intention. Further, participants in our study most preferred MaaS packages that included e-car sharing to ones with e-scooter sharing. Using latent class analysis, we classified the respondents into three different segments with varying preferences for MaaS bundle features, and conducted market simulations.
Dynamic Evaluation of Desiccant Dehumidification Evaporative Cooling Options for Greenhouse Air-Conditioning Application in Multan (Pakistan)
Authors: Ashraf Hadeed , Sultan Muhammad , Shamshiri Redmond R. , Abbas Farrukh , Farooq Muhammad , Sajjad Uzair , Md-Tahir Hafiz , Mahmood Muhammad H. , Ahmad Fiaz , Taseer Yousaf R. , Shahzad Aamir , Niazi Badar M. K.
Published: February 2021

This study provides insights into the feasibility of a desiccant dehumidification-based Maisotsenko cycle evaporative cooling (M-DAC) system for greenhouse air-conditioning application. Conventional cooling techniques include direct evaporative cooling, refrigeration systems, and passive/active ventilation. which are commonly used in Pakistan; however, they are either not feasible due to their energy cost, or they cannot efficiently provide an optimum microclimate depending on the regions, the growing seasons, and the crop being cultivated. The M-DAC system was therefore proposed and evaluated as an alternative solution for air conditioning to achieve optimum levels of vapor pressure deficit (VPD) for greenhouse crop production. The objective of this study was to investigate the thermodynamic performance of the proposed system from the viewpoints of the temperature gradient, relative humidity level, VPD, and dehumidification gradient. Results showed that the standalone desiccant air-conditioning (DAC) system created maximum dehumidification gradient (i.e., 16.8 g/kg) and maximum temperature gradient (i.e., 8.4 °C) at 24.3 g/kg and 38.6 °C ambient air conditions, respectively. The DAC coupled with a heat exchanger (DAC+HX) created a temperature gradient nearly equal to ambient air conditions, which is not in the optimal range for greenhouse growing conditions. Analysis of the M-DAC system showed that a maximum air temperature gradient, i.e., 21.9 °C at 39.2 °C ambient air condition, can be achieved, and is considered optimal for most greenhouse crops. Results were validated with two microclimate models (OptDeg and Cft) by taking into account the optimality of VPD at different growth stages of tomato plants. This study suggests that the M-DAC system is a feasible method to be considered as an efficient solution for greenhouse air-conditioning under the climate conditions of Multan (Pakistan).