bluuebunny/crossref_metadata_2025 huggingface dataset:
Long-term outcomes with nivolumab plus ipilimumab versus sunitinib in first-line treatment of patients with advanced sarcomatoid renal cell carcinoma
Authors: Rini Brian I , Signoretti Sabina , Choueiri Toni K , McDermott David F , Motzer Robert J , George Saby , Powles Thomas , Donskov Frede , Tykodi Scott S , Pal Sumanta K , Gupta Saurabh , Lee Chung-Wei , Jiang Ruiyun , Tannir Nizar M
Published: December 2022

Background

Patients with advanced renal cell carcinoma with sarcomatoid features (sRCC) have a poor prognosis and limited therapeutic options. First-line nivolumab plus ipilimumab (NIVO+IPI) provided efficacy benefits over sunitinib (SUN) in patients with intermediate/poor-risk sRCC at 42 months minimum follow-up in the phase 3 CheckMate 214 trial. In this exploratory post hoc analysis, we report clinical efficacy of NIVO+IPI in sRCC after a minimum follow-up of 5 years.

Methods

In CheckMate 214, patients with clear cell advanced RCC were randomized to NIVO 3 mg/kg plus IPI 1 mg/kg every 3 weeks (four doses), then NIVO 3 mg/kg every 2 weeks versus SUN 50 mg once daily (4 weeks; 6-week cycles). Randomized patients with sRCC were identified via independent central pathology review of archival tumor tissue or histological classification per local pathology report. Overall survival (OS), as well as progression-free survival (PFS) and objective response rate (ORR) per independent radiology review using Response Evaluation Criteria in Solid Tumors V.1.1, were evaluated in all International Metastatic Renal Cell Carcinoma Database Consortium intermediate/poor-risk sRCC patients and by baseline tumor PD-L1 expression level (≥1% vs <1%). Safety outcomes are reported using descriptive statistics.

Results

In total, 139 patients with intermediate/poor-risk sRCC were identified (NIVO+IPI, n=74; SUN, n=65). At 5 years minimum follow-up, more patients remained on treatment with NIVO+IPI versus SUN (12% vs zero). Efficacy benefits with NIVO+IPI versus SUN were maintained with median OS of 48.6 vs 14.2 months (HR 0.46), median PFS of 26.5 vs 5.5 months (HR 0.50), and ORR 60.8% vs 23.1%. In addition, median duration of response was longer (not reached vs 25.1 months), and more patients had complete responses (23.0% vs 6.2%) with NIVO+IPI versus SUN, respectively. Efficacy was better with NIVO+IPI versus SUN regardless of tumor PD-L1 expression, but the magnitude of OS, PFS, and ORR benefits with NIVO+IPI was greater for sRCC patients with tumor PD-L1 ≥1%. No new safety signals emerged in either arm with longer follow-up.

Conclusions

Among patients with intermediate/poor-risk sRCC, NIVO+IPI maintained long-term survival benefits and demonstrated durable and deep responses over SUN at minimum follow-up of 5 years, supporting NIVO+IPI as a preferred first-line therapy in this population.

Trial registration number

NCT02231749.
Understanding how college students characterise and cope with chronic pain: a thematic analysis of expressive writing samples
Authors: Root Kaitlyn , Nosek Sarah
Published: December 2022

College students who experience chronic pain are a frequently overlooked population. This research attempts to provide insight into the language that college students use to describe their experiences with chronic pain, challenges they face and coping strategies they use. Over the course of 4 consecutive days, participants responded to an expressive writing prompt asking them to reflect on their emotions and thoughts related to being a college student with chronic pain. Writing samples were then analysed to identify themes pertaining to words with a positive or negative emotional valence, terms used to characterise pain, metaphors used to describe pain, challenges faced, and positive and negative coping strategies used. Results showed that participants were more likely to use negatively valenced words than positively valenced words to describe their pain. Several common words and phrases were used to characterise pain, including metaphors. Finally, participants reported a number of challenges associated with their lived-experience of chronic pain, as well as positive and negative strategies used to cope with those challenges. These findings help to put into perspective the language used to understand, and attempt to cope with, the challenges faced by college students experiencing chronic pain. Research must continue to investigate the needs of this population so that they can be properly supported physically, emotionally, socially and academically.
Sex, relationships and ‘everyday psychology’ on British magazine problem pages, c. 1960–1990
Authors: Loughran Tracey
Published: December 2022

The later decades of the 20th century saw dramatic changes in sexual attitudes and behaviour in Britain: rates of divorce and remarriage increased; premarital sex and illegitimacy became more common, even as the pill and legal abortion opened up new reproductive choices; and following on from the decriminalisation of homosex, liberation movements began to celebrate gay lives. These shifts generated new possibilities, but often entailed much inner turmoil. The same period witnessed an unprecedented flourishing of professional and popular psychological expertise. Influential social and cultural theorists have argued that the intertwined rise of “permissiveness” and therapeutic culture caused an important shift in the ethical dimensions of modern life, in which citizens and subjects came to idolise self-realisation over the public good.

This article uses women’s magazine problem pages, exploring the role of advice columnists on and off the page, to examine the intersections of “permissiveness” and the psychologisation of everyday life. Millions looked to agony aunts in mass-market women’s magazines to help them negotiate new emotional and sexual worlds. As purveyors of counsel, but not (usually) formally trained counsellors, magazine advisors worked with the new languages and concepts of psychological expertise and disseminated them to avid readers.

Across this period, problem pages demonstrated greater openness towards sex and displacement of morality from external standards to the individual. However, advisors also continued to emphasise self-control and responsibility, and to provide practical guidance that took at best a superficially psychological veneer. These trends were underpinned by a model of sex as an essential part of loving, stable relationships, and the (largely unexpressed) notion that such relationships were essential to social functioning. In the woman’s world of the magazine, before and beyond the 1980s, the problem page does not show the rise of individualism or the pursuit of pleasure above all else.
Myeloperoxidase-positive ANCA-associated vasculitis presenting as myalgia, proximal weakness and a normal CK
Authors: Maskery Mark Peter , Whittam Daniel , Nawaraj Subedi , Chakraborti Shrijeet , Arunachalam Chera , Munavvar Mohammed , Shaik Saifuddin
Published: December 2022

We describe an unusual presentation of myeloperoxidase positive antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis managed by a multidisciplinary approach. A 75-year-old man gave a 3-week history of proximal lower limb weakness and exertional myalgia. His serum creatine kinase was normal and many of his non-specific symptoms suggested small vessel vasculitis. His investigations for common causes of muscle weakness were normal, and renal biopsy was normal despite haemoproteinuria. CT scan of the chest identified a pulmonary nodule of uncertain significance, not amenable to biopsy. MR scan of the thighs showed muscle oedema, and muscle biopsy confirmed typical features of vasculitis. Following high-dose corticosteroids his exertional myalgia quickly resolved and his normal mobility returned. Early immunosuppression is essential to improving clinical outcomes in ANCA-associated vasculitis, but diagnostic investigations often lack sensitivity.
Association between statin therapy and the risk of stroke in patients with moyamoya disease: a nationwide cohort study
Authors: Yoo Joonsang , Jeon Jimin , Baik Minyoul , Kim Jinkwon
Published: December 2022

Background and objective

Knowledge regarding the pharmacological treatment for moyamoya disease (MMD), a chronic and progressive cerebrovascular disease conferring greater stroke risk, is limited. In the present study, whether statin therapy is associated with a reduced risk of stroke in patients with MMD was investigated.

Methods

This was a retrospective cohort study in which the occurrence of stroke in patients with newly diagnosed MMD was investigated using the nationwide health insurance database in Korea from January 2007 to March 2021. A multivariable Cox proportional hazards regression model was constructed for stroke, in which statin therapy after MMD diagnosis was treated as a time-dependent variable. Adjustment was done for sex, age, presence of comorbidities, concurrent stroke, revascularisation surgery and treatment with antiplatelets.

Results

The present study included 13 373 newly diagnosed patients with MMD; 40.8% had a concurrent stroke at the time of MMD diagnosis. During the mean follow-up of 5.1±3.3 years, 631 patients (4.7%) suffered a stroke event (haemorrhagic stroke: 458 patients, ischaemic stroke: 173 patients). Statin therapy after MMD diagnosis was significantly associated with a reduced risk of stroke (adjusted HR 0.74; 95% CI 0.60 to 0.91, p=0.004). In the secondary outcome analysis, the risk of haemorrhagic stroke (adjusted HR 0.74; 95% CI 0.58 to 0.95, p=0.018) and ischaemic stroke (adjusted HR 0.75; 95% CI 0.52 to 1.08, p=0.124) were reduced with the statin treatment. Taking statins was also associated with a lower risk of all-cause mortality (adjusted HR 0.47; 95% CI 0.33 to 0.67, p<0.001).

Conclusion

In patients with MMD, statin therapy was associated with a reduced risk of subsequent stroke. The findings indicate statin treatment may be beneficial for patients with MMD, however the results should be confirmed in randomised controlled trials.
Escape, discard, and landing probability of Nephrops norvegicus in the Mediterranean Sea creel fishery
Authors: Mašanović Marina , Herrmann Bent , Brčić Jure
Published: December 2022

Size selection in creel fishery consists of two processes: the first taking place in the creel on the seabed and the second made by the fisher on the vessel. However, no study has ever considered both processes when assessing the size selection in creel fisheries. This study presents a framework for including both and demonstrates it to predict the effect of mesh size and shape on the creel fishery targeting the Norway lobster ( Nephrops norvegicus) in the Mediterranean Sea. For this specific fishery, we demonstrate that both processes play a role in the overall size selection. Furthermore, we predict an optimal creel mesh size, which potentially eliminates the second process taking place on the vessel, while maintaining high efficiency for the first process on the seabed for the targeted sizes of Nephrops. The approach here presented can be also applied to other creel fisheries.
Transmission estimation at the quantum Cramér-Rao bound with macroscopic quantum light
Authors: Woodworth Timothy S. , Hermann-Avigliano Carla , Chan Kam Wai Clifford , Marino Alberto M.
Published: December 2022

The field of quantum metrology seeks to apply quantum techniques and/or resources to classical sensing approaches with the goal of enhancing the precision in the estimation of a parameter beyond what can be achieved with classical resources. Theoretically, the fundamental minimum uncertainty in the estimation of a parameter for a given probing state is bounded by the quantum Cramér-Rao bound. From a practical perspective, it is necessary to find physical measurements that can saturate this fundamental limit and to show experimentally that it is possible to perform measurements with the required precision to do so. Here we perform experiments that saturate the quantum Cramér-Rao bound for transmission estimation over a wide range of transmissions when probing the system under study with a continuous wave bright two-mode squeezed state. To properly take into account the imperfections in the generation of the quantum state, we extend our previous theoretical results to incorporate the measured properties of the generated quantum state. For our largest transmission level of 84%, we show a 62% reduction over the optimal classical protocol in the variance in transmission estimation when probing with a bright two-mode squeezed state with −8 dB of intensity-difference squeezing. Given that transmission estimation is an integral part of many sensing protocols, such as plasmonic sensing, spectroscopy, calibration of the quantum efficiency of detectors, etc., the results presented promise to have a significant impact on a number of applications in various fields of research.
Gravastar under the framework of braneworld gravity II: Effect of the Kuchowicz metric function
Authors: Ray Saibal , Ghosh Shounak , Sengupta Rikpratik
Published: December 2022

In recent years, a class of compact objects called gravastars have drawn immense interest as regular solutions to end state stellar collapse. Since the energy density involved in collapse process is expected to be high, it is a natural choice to study such compact objects in context of modified gravity theories which reduce to General Relativity (GR) in the low energy regime. We have already framed a model of gravastar in such a modified gravity framework involving extra dimensional Randall–Sundrum (RS) single brane gravity [R. Sengupta, S. Ghosh, S. Ray, B. Mishra and S. K. Tripathy, Phys. Rev. D 102, 024037 (2020)]. As a sequel in this paper, we substantially improve our previous model by choosing the Kuchowicz function as one of the metric potentials, which leads to many new interesting results and physical features from our analysis as discussed in this paper. Also, we provide essential additional stability checks on our gravastar model to investigate the possibility of any instability creeping in due to the higher-dimensional framework. Our present improved gravastar model is found to clear all the stability checks successfully. Very interestingly, the static spherically symmetric matter distributions are found to accommodate both classes of solutions obeying and violating the modified energy conditions on the RS brane as we find in this work. We can conclude from our analysis that the Kuchowicz metric potential is very effective for describing regular solutions to compact objects at substantially high energies on the three-brane.
On equality of certain subcentral automorphisms in finite p-groups
Authors: Azhdari Zahedeh
Published: December 2022

Let [Formula: see text] be a group and [Formula: see text] be the group of all automorphisms of [Formula: see text]. In this paper, we study the structure of certain subgroups of the automorphisms group [Formula: see text] and give necessary and sufficient conditions for equality between certain subcentral automorphisms. As consequence of these results, we state a number of interesting corollaries about central automorphisms, autocentral automorphisms and derival automorphisms for finite [Formula: see text]-groups.
Holding AI to Account: Challenges for the Delivery of Trustworthy AI in Healthcare
Authors: Procter Rob , Tolmie Peter , Rouncefield Mark
Published: December 2022

The need for AI systems to provide explanations for their behaviour is now widely recognised as key to their adoption. In this article, we examine the problem of trustworthy AI and explore what delivering this means in practice, with a focus on healthcare applications. Work in this area typically treats trustworthy AI as a problem of Human–Computer Interaction involving the individual user and an AI system. However, we argue here that this overlooks the important part played by organisational accountability in how people reason about and trust AI in socio-technical settings. To illustrate the importance of organisational accountability, we present findings from ethnographic studies of breast cancer screening and cancer treatment planning in multidisciplinary team meetings to show how participants made themselves accountable both to each other and to the organisations of which they are members. We use these findings to enrich existing understandings of the requirements for trustworthy AI and to outline some candidate solutions to the problems of making AI accountable both to individual users and organisationally. We conclude by outlining the implications of this for future work on the development of trustworthy AI, including ways in which our proposed solutions may be re-used in different application settings.
How Engineers’ Imaginaries of Healthcare Shape Design and User Engagement: A Case Study of a Robotics Initiative for Geriatric Healthcare AI Applications
Authors: Breuer Svenja , Braun Maximilian , Tigard Daniel , Buyx Alena , Müller Ruth
Published: December 2022

In the development of robotics and Artificial Intelligence (AI) for healthcare, human-centered approaches seek to meet the requirements of healthcare practice and address social and ethical aspects proactively. In this work, an important but neglected aspect of human-computer interaction (HCI) is how engineers understand and envision the healthcare context. Drawing on insights from STS on engineers’ imaginaries and their role in shaping research and development of new technologies, we propose engineers’ imaginaries of healthcare as a point of analysis and intervention for ethical and social aspects of AI and robotics for healthcare. To illustrate the utility of this lens, we use it to on report a case study of an engineering project that develops robotic and AI applications for healthcare. We followed and sought to advance an embedded ethics and social science approach, where ethicists and social scientists accompanied this engineering project using direct interdisciplinary collaboration, observations, and in-depth qualitative interviews with the project’s engineers (n = 18). We analyze how the engineers imagine healthcare as an environment for robots, healthcare workers as potential users, and healthcare practices, and how these imaginaries connect to the design narratives that guide their work. Our findings provide pertinent input for HCI, STS, and engineering ethics related to healthcare AI and robotics, as they speak to prevalent narratives of “assistance” systems, aspects of how human healthcare practices are reframed and valued in the face of new technologies, questions of division of labor between machines and healthcare practitioners, and the implications of ‘acceptance’ as a frame for user-centered design.
Simulation Study of Enhancement Mode β-Ga2O3 MOSFET with Ferroelectric Charge Storage Gate Stack Structure
Authors: Yu Mingyang , Gao Huhu , Cai Yuncong , Tian Xusheng , Zhang Tao , Zhang Yuxuan , Feng Qian , Zhang Chunfu , Zhang Jincheng , Hao Yue
Published: December 2022

In this work, an enhancement-mode (E-mode) β-Ga2O3 metal-oxide-semiconductor field-effect transistor (MOSFET) with the ferroelectric charge storage gate stack structure is numerically investigated. The device is simulated from the aspects of traps and material parameters, physical models, and voltage sources. And we found that the device is optimal in performance when the ferroelectric film thickness is 17 nm and the oxide layer thickness is 5 nm. The threshold voltage shifts from −0.2 V to 4.47 V after initialization, which makes the device transit from depletion-mode (D-mode) to E-mode. Moreover, the reliability of device is presented from the aspects of repeated scanning and temperature characteristics to estimate the sensitivity of threshold voltage.
Can the introduction of an authentic learning exercise lead to the modulation of breakfast behavior in undergraduate students at University of La Réunion?
Authors: Dorsemans Anne-Claire , Essop M. Faadiel , Bourdon Emmanuel
Published: December 2022

This study introduced an authentic learning exercise (endocrinology practical exercise) to undergraduate biology students and ascertained whether it changed their views regarding the nature and regularity of breakfast meals. Here, many altered their breakfast dietary habits, which persisted even after the completion of their module. Authentic teaching approaches can therefore trigger relatively long-lasting changes in terms of breakfast behavioral patterns in young people and may also impact the broader society.
Modifying the ICP pulse wave: effects on parenchymal blood flow pulsatility
Authors: Qvarlander Sara , Dombrowski Stephen M. , Biswas Dipankar , Thyagaraj Suraj , Loth Francis , Yang Jun , Luciano Mark G.
Published: December 2022

This study demonstrated that external modification of ICP pulsatility, using a cardiac-gated inflatable device implanted epidurally in canines, alters brain tissue blood flow pulsatility. Specifically, decreasing systolic ICP increased blood flow pulsatility in brain tissue. The results suggest that the altered CBF pulsatility is unlikely to depend on modification of the Windkessel effect on the feeding arterial system but was rather an effect directly on tissue and the lower pressure distal vessels.
The effect of exercise hyperpnea on gross efficiency and anaerobic capacity estimates during a 3-min cycle time trial
Authors: Andersson Erik P. , Stöggl Thomas L. , Bachl Philipp , Osborne John O.
Published: December 2022

This study demonstrates that GE declines during a 3-min supramaximal cycle TT, which is possibly related to the hyperpneic response during supramaximal exercise. The finding from this study also provides novel insight into how the increased ventilatory energy cost from exercise-induced hyperpnea contributes to decreased GE, increased required total metabolic rate, and increased anaerobic energy expenditure during supramaximal exercise. Therefore, conventional linear models for estimating anaerobic capacity are likely to generate underestimated values.
Research on a New Control System Based on L1 Adaptive Control Scheme for the Voice Coil Motor
Authors: Jing Huaiguo , Li Ying , Li Bo , Huang Shuo , Zhan RuiDian , Li Hao , Zhang Xuexi
Published: December 2022

With the continuous development of voice coil motors, it has also been widely used in today’s sports competitions. For example, the Hawk-Eye system in tennis matches uses voice coil motors to focus on the camera to capture the trajectory of the tennis ball. Therefore, in order to better solve the problem of dynamic parameter uncertainty, external load disturbance, and tracking control of the voice coil motor servo system in motion, this paper proposes for the first time the strategy of using L1 adaptive control algorithm to control the voice coil motor servo system. First, it briefly analyzes the working principle and control method of the voice coil motor, and then constructs the uncertain parameter model according to the mathematical model of the voice coil motor. The closed-loop system of voice coil motor is simulated and analyzed by L1 adaptive controller. The results show that the L1 adaptive control method effectively suppresses the high-frequency interference caused by the voice coil motor in operation, can control the tracking error to gradually converge and so the tracking effect is better, and has strong robustness to the perturbation of system parameters. It can be applied to voice coil motor servo control.
Growth Differentiation Factor 7 Prevents Sepsis-Induced Acute Lung Injury in Mice
Authors: Dong Ping , Zhang Ying , Liu Nian , Yang Jun-Yuan , Wang Hui-Min , Geng Qing
Published: December 2022

Objective. Acute lung injury (ALI) is a life-threatening complication during sepsis and contributes to multiple organ failure and high mortality for septic patients. The present study aims to investigate the role and molecular basis of growth differentiation factor 7 (GDF7) in sepsis-induced ALI. Methods. Mice were subcutaneously injected with recombinant mouse GDF7 Protein (rmGDF7) and then intratracheally injected with lipopolysaccharide (LPS) to generate sepsis-induced ALI. Primary peritoneal macrophages were isolated to further evaluate the role and underlying mechanism of GDF7 in vitro. Results. GDF7 was downregulated in LPS-stimulated lung tissues, and rmGDF7 treatment significantly inhibited inflammation and oxidative stress in ALI mice, thereby preventing LPS-induced pulmonary injury and dysfunction. Mechanistically, we found that rmGDF7 activated AMP-activated protein kinase (AMPK), and AMPK inhibition significantly blocked the anti-inflammatory and antioxidant effects of rmGDF7 during LPS-induced ALI. Further findings revealed that rmGDF7 activated AMPK through a downregulated stimulator of interferon gene (STING) in vivo and in vitro. Conclusion. GDF7 prevents LPS-induced inflammatory response, oxidative stress, and ALI by regulating the STING/AMPK pathway. Our findings for the first time identify GDF7 as a potential agent for the treatment of sepsis-induced ALI.
Analysis of Crashworthiness of Bishoftu Pickup Vehicle Structure during Side Pole Crash
Authors: Gashu Adane , Nallamothu Ramesh Babu
Published: December 2022

Now a day’s, vehicle accident is becoming a critical issue all over the world, especially in Ethiopia. These vehicles have not been checked for any crash safety test specifications and are not evaluated for crashworthiness. So, it is now time to consider the safety features of Bishoftu pickup vehicles (BPV) to reduce the grave consequences for their users. This paper aimed to improve the crashworthiness of the existing Bishoftu pickup vehicle through remodeling. The structural response to a frontal collision with an existing BPV is analyzed. Based on the results obtained from the existing model, modifications are made by means of energy-absorbing components, a stable frame structure, and better crash performance. For doing the analysis software like CATIA is used for 3D modeling, and LS-DYNA is used for FEM analysis. The results show that by applying the modification, 39 kN (7.82%) of impact force is reduced and 5 kJ (3.52%) of additional energy is absorbed during the frontal collision. Finally, it can be concluded that with the modified model, the safety and crashworthiness of the BPV were greatly improved without affecting the appearance and weight of the existing one.
The trigger factors of domestic violence among mothers during pregnancy
Authors: Raden Natalia Damaiyanti Putri , Zuhriyah Lilik , Andarini Sri
Published: December 2022

Domestic violence also called "domestic abuse" or "intimate partner violence", can be defined as a pattern of behavior in any relationship that is used to gain or maintain power and control over an intimate partner. Abuse is physical, sexual, emotional, economic, or psychological actions or threats of actions that influence another person. This includes any behaviors that frighten, intimidate, terrorize, manipulate, hurt, humiliate, blame, injure, or wound someone. Furthermore, it is common among women, which globally increases the risk of pregnancy. This research aimed to analyze the trigger factors of domestic violence among pregnant women. The interviews with eight participants were analyzed using the Colaizzi method. It produced five main themes, namely, the husband is often angry and fight since having an affair, income is not sufficient to fulfill the monthly needs, fights because the husband feels jealous, the husband is temperament, smacks, and also berates when drunk, fights because husband spends money on gambling.
Evaluating the effect of COVID-19 pandemic on the psychological health of young adults in India
Authors: Sabharwal Alka , Goyal Babita , Chauhan Vibha S , Joshi Lalit Mohan , Goyal Vaibhav
Published: December 2022

COVID-19 pandemic has affected the mental health of individuals, particularly young adults. Using the ‘strength and difficulty questionnaire 17+ extended version’, we studied the severity of psychological problems and the resultant distress in young adults; the relationship between the ‘difficulty’ and ‘impact’ scores; and the effect of distress in terms of a number of day-to-day activities affected during a pandemic. Data was collected from 743 college/university students (December 2020-February 2021) in India. Descriptive, relative frequencies, and nonparametric tests are applied here. Females were facing more psychological behavioral problems as compared to males as the p-value is less than 0.001. Males with age<20 years were least affected by COVID-19. Day-to-day activities are affected by almost 45% of young adults because of distress. ‘difficulty’ and ‘impact’ severity bands were significantly different from the previous standard proportions. No significant association was there between ‘difficulty’ and ‘impact’ scores (p-value<0.001). 53% of those contracting COVID-19 had severe distress as against 45% of those who did not. 46% of the respondents were in the ‘abnormal’ category and 59 out of 327 were facing ’a great deal’ problems in more than two areas.
Related factors of actual turnover among nurses: a cross-sectional study
Authors: Rindu Rindu , Hafizurrachman Muhammad
Published: December 2022

Turnover exacerbates the global nursing shortage; the loss of skilled and expert nurses has a negative impact on patient outcomes. The study examined the influence of job satisfaction, work environment, leadership styles, organizational commitment and work-family support on actual turnover among nurses working in the hospital of Indonesia. A cross-sectional survey was carried out in Jakarta, Indonesia. The sample in this study was nurses who leave the jobs from hospital during period of time October 2019 to October 2020. A total of 170 nurses responded to the survey. Nurses reported poor leadership style (2.84±0.82), organization commitment (2.99±0.76), as well as dissatisfaction with organization (2.76±0.80) and leadership support (2.89±0.89). Job satisfaction (p=0.007), work environment (p=0.032), leadership style (p=0.001), organizational commitment (p=0.010), and work-family support (p=0.026) remained statistically significant affected turnover. The findings of this study emphasize the critical role of satisfaction, organizational commitment, work-family support, and leadership style in determining nurse intention to stay and provide employers with a road map for reducing turnover. Future studies may need to understand more deeper regarding the actual turnover experience and its associated factors using longitudinal or qualitative studies.
Communicating health and risk information among senior citizens in Bangladesh
Authors: Aminul Islam Mohammad , Islam Sizear Monaemul , Akhtar Sharmin , Huq Monimul
Published: December 2022

The coronavirus disease-2019 (COVID-19) pandemic has affected human being in multiple ways all over the world. Senior citizens are more likely to get sick from COVID-19 compared to other age groups. Little is known about ways to deliver the messages to adult people to get the best outcome. We conducted a direct telephone/mobile phone-based cross-sectional survey among individuals who were aged >60 years old in Bangladesh. Verbal consent was taken and the snowball sampling method was used to reach the participants. This study showed that the most common sources of information about COVID-19 were family members, relatives, friends, and electronic media. Hence, 36.8% participants perceived that the media massages about COVID-19 were difficult to understand. Meanwhile, 53% participants could not understand the meanings news and information as those were presented using unknown terminologies. From the findings it can be concluded that the media messages should be communicated in a way that are context-specific and understandable, especially using more convenient terminology for better understanding for all levels of people.
The live experience of people suffered by leprosy
Authors: Mukhlasin Mukhlasin , Sansuwito Tukimin , Elengoe Asita , Kusuma Andiko Nugraha
Published: December 2022

Leprosy, unlike other high-fatality diseases, is a long-term, chronic illness that can cause long-term disability. People's experiences with leprosy in Indonesia, indicating a need for responsive leprosy services to meet the wide range of requirements, including care for those who are not formally afflicted with the disease. This study aimed to explore live experience of people affected by leprosy in the community in Banten province, Indonesia. This study employed inductive phenomenological research methods with a semi-structure interview. We used snowball sampling, and people who could not communicate or did not want to take part in the study were not included. The majority of the participants were below 45 years, and 21 were male and 19 were female. Among total participants, only 15% could not read and write. The data were examined using Colaizzi's phenomenological analysis, which involves collecting and analysing data in parallel until no new information is acquired. We established trustworthiness in qualitative studies. The following themes emerged from this study: i) public understanding about leprosy; ii) psychological response; iii) perceived stigma; iv) health seeking behavior; and v) leprosy's impact on economic condition. This study identified the meaning of leprosy patients' lives through their own voices. People who have leprosy should also get spiritual help, coping skills, and training in self-care skills.
Boosting the quality of life through additional general allocation funds for village infrastructure development
Authors: Khusaini Khusaini , Bastian Asep Ferry , Latuconsina Hudaya , Pratama Rommy
Published: December 2022

Improving the quality of life of the community as one of the key indicators of development success is a must since it has an impact on the wellbeing of the community. This study aims to measure quality of life and analyze the effect of additional general allocation funds for village infrastructure development, education, and control variables on the quality of life of the community who lived in Tangerang. The researchers employed a sample size of 368 people. Using a cross-sectional survey approach, valid, and reliable questionnaires were distributed. The results of the multiple regression analysis showed that the general allocation funds for the village infrastructure development were proven to have a significant effect on improving the quality of life of the community. The education level variable did not have a significant effect on improving the quality of life, but it had a significant effect on the psychological health domain of quality of life. In addition to the provision and maintenance of health services, it is necessary for the government to include the construction of infiltration wells, community-based domestic wastewater management networks, light fire extinguishers, and portable fire pumps as development priorities.
Heart disease mortality in the Philippines from 1960 to 2019: a big data analysis
Authors: Cabanlit Kathleen Laum , Morilla Ralf Benjo Goder , Luga Angel Mae Frias , Sidic Jamerah Baniaga , Demayo Chin-chin Jimenea , Demayo Cesar Guinanao
Published: December 2022

Heart diseases remain one of the major health concerns worldwide, inflicting a tremendous financial burden, especially in low to middle-income countries like the Philippines. An exhaustive time-trend analysis, including recent data, is essential to measure the nation's progress in cardiac health, capturing the effect of national-scale changes over time. Thus, using stored data from the Philippine health statistics, this study analyzed trends and profiles of heart disease mortality in the Philippines from 1960 to 2019 and discussed relevant national policies for greater recognition and awareness. Ischaemic heart disease constituted the most significant proportion of mortality among all types. Steadily increasing trends by cause, gender, age group were observed, and with males and the elderly population having higher rates. Regional differences also existed, having the highest rates in Luzon, the Visayas, and Mindanao respectively. Like global patterns, heart disease remained one of the country's leading causes of mortality over decades. Differences between genderes, age groups, and regions are attributed to complex and interrelated factors making males, the elderly, and highly urbanized areas most vulnerable among the population.
Anxiety status of junior archers in COVID-19 during training isolation period towards the shooting performance
Authors: Wan Ahmad Wan Nurlisa , Mohd Adib Mohd Azrul Hisham , Mat Nashir Irdayanti , Sut Txi Mon Redee , Mat Salleh Fatin Nurfatehah , Tang Jing Rui
Published: December 2022

Studies have indicated that the COVID-19 pandemic has had miserable effects on athlete performance due to the movement control order (MCO) announced by the Malaysia Government. Dealing with self-training without the coach's guidance leads the archers to lose concentration, diminished self-confidence, and elevated anxiety levels. These factors contribute to inconsistent shooting performance. This study attempted to identify the archer's anxiety status during the training isolation period on the shooting performance. A total of 32 participants from the recurve archery category were recruited and enrolled in a web-based cross-sectional study during the MCO. The CSAI-2R instrument was applied to participants to examine the psychological aspect. Training Isolation resulted in a significant effect on anxiety status and shooting performance. Analysis from CSAI-2R, low-level archers, indicated 5% more anxiety than top-level archers for both cognitive and somatic anxiety sub-component. In contrast, Top archers revealed a higher self-confidence mean of 2.32 (moderately high) than low archers (1.38). The result shows improvement in anxiety and score performance with complete online monitoring and coaching supervision first session until the 8th session. These findings could assist sports institutions in improving a better training experience and understanding the pandemic's impact on athletes' mental health during home isolation.
COVID-19 vaccine hesitancy among the university students and personnel
Authors: Santiago Jomell Miranda , Santos Angelo R. , M. Gamit Analyn
Published: December 2022

A delay in accepting or refusing a vaccination despite the availability of vaccination services is described as vaccine hesitancy. The vaccine hesitancy among the Filipinos is a significant challenge to achieving herd immunity. Thus, this study was conducted to determine the COVID-19 vaccine hesitancy of Nueva Ecija University of Science and Technology students and staff. Total sampling and descriptive study methodology were employed. To gather information about the profile, information sources, and hesitation regarding the COVID-19 vaccine, a questionnaire was created. Both informed consent and permission to conduct were secured. Researchers used a variety of statistical tools to assess the data. The respondents’ likely reasons to get vaccinated were to protect themselves and others, and the recommendation from a healthcare provider can help encourage those hesitant to get vaccinated. Moreover, the main reasons for their hesitancy were their fear of the side effects, and poor knowledge about the vaccine. With this, educational programs meant to educate those individuals who had vaccine hesitancy must be conducted. Moreover, vaccine hesitancy must be monitored, as it is expected to vary over time. Therefore, campaigns to disseminate the importance of the vaccine in the nation's public health must be continuously conducted for all types of diseases.
What promotes cognitive dissonance among anti-vaccine members in Indonesia?
Authors: Thamrin Muhammad Husni , Bafadhal Oemar Madri , Santoso Anang Dwi
Published: December 2022

This study aimed to examine the influence of expectations on vaccines, trust in government, perceived threats, and information overload to cognitive dissonance and its implications for vaccine use, behavioral negotiation, and information avoidance. After we formulated eight hypotheses, all of them was tested using the partial least squares structural equation modeling (PLS-SEM) method. This study involved 173 community members to fill out a questionnaire with 31 questions. The results showed that expectations of vaccines and information overload affected cognitive dissonance. In contrast, the perceived threat due to the COVID-19 pandemic and trust in the government did not affect cognitive dissonance. We also found that cognitive dissonance negatively and significantly affected vaccine use and positively and significantly affected behavior to continue negotiating and avoiding information related to COVID-19 vaccination. This study is among the first to examine members of the anti-vaccine community quantitatively and practically attempts to intervene in the anti-vaccine community so that they are cognitively dissonant are to increase expectations of vaccination and confuse them by presenting the information overload they receive.
Strategy to control and eradicate dengue hemorrhagic fever vectors in Bali
Authors: Mertha Adnyana I Made Dwi , Surya Asik
Published: December 2022

Dengue hemorrhagic fever cases in Bali have increased in the past decade. Control and eradication efforts must be optimized. In order to create dengue-free zones, accurate information and a comprehensive strategy for accelerating dengue vector management are required. This paper is based on empirical, field, and epidemiological studies and program evaluations guided by the health belief model approach. In this regard, Bali's lesson on dengue cases fluctuated from 2018 to 2020. The incidence and death rates are increasing, especially during the COVID-19. Many factors affect the disease agent, the host, and the environment. The SIGAP strategy is a policy brief that is studied and implemented to accelerate dengue vector control in Bali, which includes: awareness of the importance of 4M-Plus (draining, closing, reusing used goods, and monitoring) and mosquito nest control; integration of dengue information services; using natural insecticides and larvicides; observing and reporting the presence of vectors to the larva monitoring officer; and regular monitoring weekly. Implementing the SIGAP strategy can reduce dengue vectors and speed up the process of getting rid of dengue disease in Bali.
Health and safety risks behavior among local and international tourists at Borobudur Temple before COVID-19 pandemic
Authors: Shaluhiyah Zahroh , Suryoputro Antono , Septialti Delita
Published: December 2022

Tourists are vulnerable to certain diseases and health-related issues, including experiencing danger during their visit to a destination. This study aims to compare the health and safety behavior of local and foreign tourists during their visit to Borobudur Temple, Indonesia from September to November 2019. Additionally, it was carried out quantitatively with a cross-sectional approach. The sample consisted of 200 foreign and 200 local tourists visiting Borobudur Temple; they were selected using convenient sampling. The data were analyzed using the frequency distribution and the Chi-square test. The results showed that health risks related to food and beverage hygiene were the most experienced by foreign tourists (p-value 0.030), and solar radiation effects were experienced by both foreign and local tourists (p-value 0.006). Tourists' knowledge to prevent health and safety risks was categorized as moderately adequate, and foreign tourists have more understanding than their local counterparts. This study reported no difference in health and safety behaviors between foreign and local tourists. It was suggested that tourism managers should provide information to the visitors concerning health and safety risks prevention by delivering leaflets, booklets, and brochures to minimize danger, sunburn, and food as well as beverage-related diseases.
In vitro study of the preventive activity of fluoride varnish by X-ray diffraction
Authors: Damyanova Dobrinka Mitkova , Atanasova Siyana Georgieva
Published: December 2022

In exogenous prophylaxis, fluoride is applied directly to the tooth surface through various gels, varnishes, foams, and toothpaste. According to the global burden of disease study conducted in 2017, more than 530 million children worldwide suffer from dental caries in their primary dentition. There are few developments in the selection of non-invasive methods in the application of mineralizing varnishes. The researchers investigated experimentally, in-vitro the preventive activity of the fluoride varnish Clinpro™ White Varnish with TCP 3M (CV), using a modern method of X-ray diffraction. The 20 temporary teeth were extracted due to physiological changes. Place of study was UMDC - city of Varna and Institute of Physical Chemistry "Academician Rostislav Kaishev" of the Bulgarian Academy of Sciences, Sofia. Demineralization is carried out with 37% phosphoric acid (i-gel – etching gel) and applied to the smooth temporary enamel surfaces for 30 seconds. The models were then washed and dried with a water and air jet. Remineralization was performed with CV. The formation of small globules of calcium fluoride. The coating is composed mainly of fluorapatite. With the modern method of X-ray diffraction, it was proved that exogenous fluoride prophylaxis and remineralization therapy are effective methods of prevention and treatment of initial caries lesions.
Vaccination efficacy against post-COVID-19 symptoms in Delta and Omicron waves: a prospective cohort in East Indonesia
Authors: Masrika Nur Upik En , Nugroho Aryandhito Widhi , Viwattanakulvanid Pramon , Herman Bumi
Published: December 2022

The post COVID-19 symptoms affect the productivity and the quality of life among survivors. It is imperative to identify the effect of virus variants and the vaccination against post-COVID-19 symptoms. There were 242 participants from the eastern part of Indonesia diagnosed with COVID-19 during July 2021-July to 2022 were recruited online. The participants underwent data collection and semi-clinical follow-up for post-COVID-19 symptoms within 30 days after the first symptoms or from the diagnosis day using a validated clinical questionnaire and physician confirmation. Fatigue was the most reported post-COVID-19 symptom (27.7%), followed by chronic cough (21.5%) and headache (15.3%). Adjusted by confounding factors in hierarchical logistic regression, the differences in post-COVID-19 symptoms were insignificant across different variants. Regarding vaccine efficacy against three post-COVID-19 symptoms, people with two-dose vaccination significantly reported lower post-COVID-19 chronic cough (adjusted Odds Ratio 0.244 95% CI OR 0.071-0.838), but the protection against fatigue and the chronic headache was insignificant. There is an indication that vaccine efficacy may be waning along with the emerging new variants.
Legality of therapeutic contract of stem cell treatment in Indonesia
Authors: Lestari Ahdiana Yuni , Muhammad Danang Wahyu , Al Kautsar Izzy , Jenie Siti Ismijati
Published: December 2022

This study analyzed the purposes and functions of stem cell treatment arrangements in Indonesian national law and then describe the characteristics of therapeutic agreements between patients and elements of health services against the legal terms of the agreement based on the Civil Code. This study used a normative juridical research method. The results of this study are: i) in terms of stem cell treatment procedures, only some can get services and treatment because the procedure is very complicated and lengthy. Hence, the purpose and function of regulating the implementation of stem cell treatment in Indonesia are to provide legal certainty and protection law to the public and health service providers; ii) the conditions for the validity of a stem cell Therapeutic agreement must be based on the criteria specified in Article 1,320 of the Civil Code, then the elements of the parties that bind themselves; the skills of the parties; particular object, and lawful cause must be clear, and iii) the type of therapeutic contract that can maintain the honor of the parties is the "three in one" model. However, this model currently needs to be improved in Indonesia because of the novelty of the regulatory framework.