bluuebunny/crossref_metadata_2025 huggingface dataset:
Transcriptomic study of the cell death-related pathways of cervical cancer HeLa cells in response to Clinacanthus nutans treatment
Authors: Adum Kristine Sandra Pey , Haron Nor Hasyimah binti , Toha Zaleha binti , Arsad Hasni bin
Published: July 2022

Background: Recent years have witnessed major development of novel therapeutic agents like chemotherapy, targeted therapy and immune checkpoint inhibitors for cervical cancer. However, cervical cancer remains prevalent, leading to a large number of deaths worldwide. A better understanding of the cervical cancer biology and signaling pathways might lead to the development of targeted therapies in reducing the incidence and mortality rate. Methods: In this study, the RNA-Seq reads of HeLa cells treated with C. nutans were compared to the untreated sample. The reads of these two sample groups were firstly aligned to the human reference genome. The results in BAM files format that were generated were then sorted before being assembled. The output of assembly which was in coverage table form was ready for downstream statistical analyses for differential expression. Differentially expressed genes were obtained and the cell-death related pathway were identified by canonical pathway, QIAGEN Ingenuity Pathway Analysis (IPA). The verification of significant genes was carried out using qRT-PCR by including GAPDH as a housekeeping gene Results: With this, we identified a total of 668 upregulated and 479 downregulated analysis-ready genes across observations upon cut-off setting log2FoldChange at 0.5 and P-value 0.05. A total of 28 cell-death related canonical pathways and 4 activation of cell-death related functions were identified. Upon analyses, we identified four significant genes (Casp9, KAI1, REL and FOXO4) that hold important role in promoting cell death. These findings were also verified against the quantification using qRT-PCR by including GAPDH as a housekeeping gene. Conclusions: This study provides an insight on the potential role of DCM fraction of C. nutans in activating Casp9, KAI1, REL and FOXO4 genes in mediating apoptosis in cervical cancer cells.
Researching, Co-creating and Testing Innovations in Paper Health Information Systems (PHISICC) to Support Health Workers Decision-making: Protocol of a Multi-country, Transdisciplinary, Mixed-methods Research Programme in Three Sub-saharan Countries
Authors: Bosch-Capblanch Xavier , O’Donnell David , Krause L Kendall , Auer Christian , Oyo-Ita Angela , Samba Mamadou , Matsinhe Graça , Garba Abdullahi Bulama , Rodríguez Damaris , Zuske Meike , Njepuome Anthonia Ngozi , Lee Sofia Micael Mandjate , Ross Amanda , Gajewski Suzanne , Muloliwa Artur Manuel , Yapi Richard B , Brown David W
Published: July 2022

BackgroundHealth Information Systems are crucial to provide data for decision-making and data demands are constantly growing. However, the link between data and decisions is not always rational nor linear and the management of data ends up overloading frontline health workers, who may have to compromise the health care. Despite limited evidence, there is an increasing push for the digitalisation of Health Information Systems, which faces enormous challenges, particularly in remote, rural settings in low- and middle-income countries. Paper-based tools will continue to be used and this warrants efforts to make them more responsive to local needs. Paper Health Information Systems (PHISICC) is a transdisciplinary, multi-country research initiative to create and test innovative paper-based Health Information Systems in three Sub-Saharan African countries.MethodsThe PHISICC initiative is taking place in remote, rural settings, in Côte d’Ivoire, Mozambique and Nigeria, through partnership with Ministries of Health and research institutions. We began with research syntheses to acquire the most up to date knowledge on Health Information Systems. These were coupled with field work in the three countries to understand the current design, patterns and contexts of use, and health care worker perspectives. Frontline health workers, with designers and researchers, used co-creation methods to produce the new PHISICC tools. This suite of tools is being tested in the three countries. Throughout the project, we have engaged with a wide range of stakeholders and have kept the highest scientific standards to keep it relevant to health policy in each of the three countries.DiscussionWe have deployed a comprehensive research approach to ensure the robustness and future policy uptake of the finding. Beyond the resulting paper-based tool design innovations, our process itself was innovative. Rather than emphasizing the data management compliance aspects we focused instead on frontline health workers’ decision-making; by tackling the whole scope of health care areas in Primary Health Care rather than incremental improvement to existing tools, we developed an entirely new design approach and language for a suite of tools in Primary Health Care. The initiative is being tested in remote, rural areas where the most vulnerable live.
Roton pair density wave and unconventional strong-coupling superconductivity in a topological kagome metal
Authors: Gao Hong-Jun , Chen Hui , Yang Haitao , Hu Bin , Zhao Zhen , Yuan Jie , Xing Yuqing , Qian Guojian , Huang Zihao , Li Geng , Ye Yuhan , Ma Sheng , Ni Shunli , Zhang Hua , Yin Qiangwei , Gong Chunsheng , Tu Zhijun , Lei Hechang , Tan Hengxin , Zhou Sen , Shen Chengmin , Dong Xiaoli , Yan Binghai , Wang Ziqiang
Published: July 2022

The recently discovered family of vanadium-based kagome metals with topological band structures offer new opportunities to study frustrated, correlated topological quantum states. These layered compounds are nonmagnetic and undergo charge density wave (CDW) transitions before developing superconductivity at low temperatures. Here we report the observation of unconventional superconductivity and pair density wave (PDW) in the vanadium-based kagome metal CsV3Sb5 using scanning tunneling microscope/spectroscopy (STM/STS) and Josephson STS. The differential conductance exhibits a V-shaped pairing gap Δ~0.5 meV below a transition temperature Tc~2.3 K. Superconducting phase coherence is observed by Josephson effect and Cooper-pair tunneling using a superconducting tip. We find that CsV3Sb5 is a strong-coupling superconductor (2∆/kBTc~5) and coexists with long-range 4a0 unidirectional and 2×2 charge order. Remarkably, we discover a bidirectional PDW accompanied by 4a0/3 spatial modulations of the coherence peak and gap-depth in the tunneling conductance. We term this novel quantum state a roton-PDW that can produce a commensurate vortex-antivortex lattice and account for the observed conductance modulations. Above Tc, we observe a large V-shaped pseudogap in the 4a0 unidirectional and 2a0 bidirectional CDW state. Electron-phonon calculations attribute the 2×2 CDW to phonon softening induced structural reconstruction, but the phonon mediated pairing cannot describe the observed strong-coupling superconductor. Our findings show that electron correlations drive the 4a0 unidirectional CDW, unconventional superconductivity, and roton-PDW with striking analogies and distinctions to the phenomenology of high-Tc cuprate superconductors, and provide groundwork for understanding their microscopic origins in vanadium-based kagome superconductors.
Scenario-Based Risk Assessment for Düzce Province
Authors: MIHÇI Zeynep , BAYRAKTAR Hüseyin
Published: July 2022

However, following the earthquake event of 12 November 1999, 80% of the built environment in the Düzce area had been destroyed and after the removal of the ruins, it was transformed into a huge open space. Subsequently, on 9 December 1999, Düzce was declared the provincial capital city, having 20 neighborhoods, 97 villages, and 7 districts under its administration. The main components featured in this study are 10 urban neighborhoods of Düzce that are all comprised of structural and natural environments located in the vicinity of the North Anatolian Fault Line. These areas are briefly defined and some benefits from their restructuring as viewed within this framework are presented. The most important result we obtained as a result of the earthquake scenario prepared for Düzce province; The fact that the ten neighborhoods we examined in the central district of Düzce are at a critical point on the fault line and Most of the buildings here were affected by the 17 August 1999 Izmit Gulf earthquake, If the buildings encounter a possible earthquake of this magnitude, it may be effective in the high number of dead and injured. Another important finding is; The main purpose of earthquake risk analyzes is to determine the number of tents that may be needed in advance and the area required for the tent. As a result; This study, which was carried out in the central district of Düzce province, will ensure that the necessary precautions are taken beforehand in case of a possible earthquake, and that the loss of life will be reduced to a minimum by acting more planned and faster at that time.
SIMP Dark Matter
Authors: Hochberg Yonit
Published: July 2022

These notes summarize the zoom-course on Strongly Interacting Massive Particle (SIMP) dark matter given at the Les Houches Summer School in the summer of 2021. An alternative title for this course would be `SIMPS, Cannibals and ELDERs', where our focus is on high-point interactions amongst dark matter particles. The spirit of the course is to give students a taste of these exciting developments in dark matter, while primarily teaching tricks and methods that are tough to captivate when reading textbooks or papers. These notes are written in similar spirit: I will put emphasis on how quantities scale and how to perform back of the envelope estimates, which should serve to help you when you develop the next great dark matter idea.
STUDY OF SERUM CALCIUM, CREATININE AND URIC ACID IN HYPOTHYROID PATIENTS
Authors:   Department of BiochemistrySri Venkateswara Medical College Tirupati., Laxmi Pasupurekula , a Srirekha ,   Department of Biochemistry Kurnool Medical College Kurnool.
Published: July 2022

Aim: The study is to determine Serum Calcium, Creatinine and Uric acid levels in hypothyroidism cases. Materials and methods: A total of 25cases were selected randomly for one year study from SVRRGGH, Tirupati with exclusion criteria (renal disease, bone disease, diabetes mellitus and other medical conditions and patients who are on medication that going to affect purines and mineral metabolism). Sca2+, creatinine and SUA were done on Erbachem 5X and thyroid hormones were done chemiluminescence. Results: The mean values of serum calcium were low and creatinine and SUA levels were high in hypothyroidism cases. The p value is <0.0001 and is considered highly significant and TSH were correlated with this parameters for knowing effect of hypothyroidism on renal function, mineral and purine metabolism. Conclusion : Hypothyroidism patients need to be regularly evaluated for these parameters, as early detection and correction can prevent the complications associated with this metabolic dysfunction.
THE CONCEPT OF MEDIATION IN ALTERNATIVE DISPUTE RESOLUTION (ADR) AND ITS IMPLEMENTATION AGAINST RELIGIOUS CONFLICT MANAGEMENT
Authors:   Master of Islamic Studies, Research Centre for Theology and Philosophy,Faculty of Islamic Studies,UniversitiKebangsaan Malaysia., Fatimah Ishak Siti , Farhana Abdul Rahman Nur ,   Senior Lecturer, Research Centre for Theology and Philosophy, Faculty of Islamic Studies, UniversitiKebangsaan Malaysia.
Published: July 2022

Religious conflicts are increasingly covered by the media these days, such conflicts if not managed properly can lead to wars and killings as has happened abroad and others have taken the time to use the legal process. Therefore, this article aims to discuss the concept of Alternative Dispute Resolution (ADR) mediation and its implementation against religious conflict resolution. Researchers use a qualitative method, which is a literature review and analysis of previous writings. As a result, the study found that the method of mediation in the Alternative Dispute Resolution (ADR) is very suitable for dealing with religious conflicts, since it does not take long and can satisfy both conflicting parties to lead to peace.
ANALYZING INDIAS BALANCE OF PAYMENTS POSITION DURING THE PANDEMIC PERIOD
Authors: Saravanan S. , Vijaya Kumar V.
Published: July 2022

The current pandemic scenario is trying with the administration limits and wellbeing health frameworks across countries, and handles its socio-economic consequences. According to different reports, the health emergency which initially began as a wellbeing crisis has converted a worldwide financial turmoil on scales like the incredible downturn of 2007-08. According to the World Economic Outlook, the projection of worldwide development in 2020 will tumble to - 3 percent which is essentially lower than the development paces of - 0.1 percent during the 2009 financial turmoil. This has the monetary effect of Covid-19 far more highly contrasted with the 2009 worldwide financial crisis, making it the most exceedingly terrible downturn since the Great Depression of 1930s. An earnest attempt has been made in this paper to articulate the Indias Balance of payment position during the pandemic period. To conclude, No doubt the Indias balance of payment is surplus after a long gap of 18 years.
REGENERATIVE ABILITIES OF PLANARIANS AND ITS INFLUENCE ON THE FUTURE OF REGENERATIVE MEDICINE
Authors:   Thai Chinese International School., Uppaputthangkul Pimrak
Published: July 2022

The regenerative abilities of a particular species of flatworm, the planarian, have been a topic of discussion and interest among scientists. These animals can regenerate parts of their body that have been cut off. This review includes the general introduction of planarians, the types of stem cells in its body, its basic anatomy and physiology, behavior, regeneration process, and applications to the medical field. We also predict the future of regenerative medicine that could be achieved by studying this particular animal model.
ULUSLARARASI HUKUKTA KAVRAMLAR ARACILIĞI İLE OLGUDA MANİPÜLASYON
Authors: AKPINARLI Neyire
Published: July 2022

İlk siyasi oluşumlardan bugüne insanoğlunun birikimleri üzerine inşa edilmiş mevcut uluslararası hukuk, Avrupa Bölgesel Hukukunun temel yapı taşları ile tanımlanmış ve I ve II. Dünya Savaşları, son olarak da Soğuk Savaş galiplerinin çıkarlarına göre şekillenmiştir. Bu şekillenme; uluslararası hukuk tarihinin yazımından uluslararası örgütlere ve uluslararası antlaşmalara kadar geniş bir alanda olmaktadır. Bu şekillenmenin önemli araçlarından biri de uluslararası hukuk kavramlarıdır. Kavramlar ile olguda manipülasyon yaratılmakta ve bu sayede güçlü devletlerin uluslararası kurum ve kuralları kendi lehlerine araçsallaştırarak uluslararası hukuka aykırı fiillerinin meşrulaştırılması ya da uluslararası hukuka uygun bir fiile dönüştürmesi sağlanmaktadır. Çalışmada başarısız devlet, yaptırım ve azınlık kavramları üzerinden bu uluslararası hukukta kavramların işlevi incelenecektir. Burada her bir kavram bağlamında kavramın başat anlamı ve kavram altında oluşturulan kurguda olgunun nasıl tanımlandığı, olgunun uluslararası hukukta görünümü ve kavram ile oluşturulan algı yanılgısı ortaya konulacaktır. Araştırma verileri üzerinden temel çıkarımlar yapıldıktan sonra Türkçe uluslararası hukuk literatüründe uluslararası hukuk kavramlarına karşı eleştirel bakış açısının varlığı sorgulanacaktır.
Hydroxylamine-enhanced Fe(II)-peroxymonosulfate activation for efficient degradation of organic pollutants: optimization by response surface methodology
Authors: Zhang Kuo , Zhang Ming , Zhou Runjuan , Zhou Ting
Published: July 2022

In this work, the response surface methodology (RSM) was used to model and optimize the hydroxylamine (HA) enhanced Fe(II)/peroxymonosulfate (PMS) process. The enhanced effect of HA on the degradation efficiency of Orange II (AO7) in the Fe(II)/PMS system was quantitatively analyzed. Pareto analysis showed that the individual and interactive effects of HA, Fe(II) and PMS were of the following order: HA > Fe(II) > PMS and Fe(II)/PMS > HA/PMS > Fe(II)/HA. The optimal conditions of HA/Fe(II)/PMS system were as follows: Fe(II) concentration was 34.0 μM, HA concentration was 0.4 mM, and PMS concentration was 0.9 mM. When the initial pH was 4.0–6.0, the degradation efficiency of AO7 in the HA/Fe(II)/PMS system was significantly higher than that in the Fe(II)/PMS system (P < 0.05). Hydroxylamine enhances the degradation of AO7 in the Fe(II)/PMS system by reducing Fe(III) to Fe(II). The results of quenching experiment showed that SO4•− was the dominating reactive oxygen species (ROS) in the HA/Fe(II)/PMS system. In the HA/Fe(II)/PMS system, CO32− and humic acid inhibited the degradation efficiency of AO7. This work provides a novel mathematical model for the degradation of AO7 in the HA/Fe(II)/PMS system, which can be popularized and applied in similar experiments.
North African countries: economic development and readiness for digitalization
Authors: Shkvarya L V.
Published: July 2022

The author believes that the countries of North Africa, with a much differentiated level of socio- economic and digital development, already have certain opportunities for digital development, the need for such development and the creation of digital potential, including in the field of digital trade. However, in our opinion, the countries of the region currently lack a strategic understanding of specific industry tasks in the field of digitalization. It is important to strengthen the presence of the Russian Federation in the digital segment of the region, especially in key segments of the economy. According to the author, the prerequisites for strengthening cooperation in this segment really exist, in particular, they are predetermined by both a fairly active digitalization in the Russian Federation and the growth of Russian-North African trade in the commodity segment and in the service sector based on the growing interest of the parties in the further development of bilateral cooperation, taking into account the growth of global uncertainty.
Global competition in new technology realities
Authors: Lebedeva L. F. , Aksenov P. A.
Published: July 2022

Global competition in modern realities with rapid changes in technology brings new tasks for national policies, taking into consideration tightening restrictions on technology exports. So improving competitive strategy, with new technologies being a critical part of it, finding additional pathways to meet the challenges is on the agenda. The paper focuses on ranking countries not only by creating technologies, including frontier ones, but being prepared for them as well. The readiness index has been designed to rank countries by national capabilities to create, use, adopt and adapt technologies. This index includes such elements as R&D activities, ICT development, skills, the capacity to use in industry, access to finance. Among the best - ready countries are the United States, followed by Switzerland, the United Kingdom, Sweden, Singapore, the Netherlands, the Republic of Korea. Most of the least-ready countries are in the developing countries. The ranking by each element is not less important and shows wide range of inequalities between countries as to skills or the capacity to use new technologies in industry or access to finance etc. Strengthening all of these elements are critically important for meeting competitive challenges.
Construction and use of real-time seismic velocity change detection system to monitor the temporal and spatial changes of crustal stress and fault activity in Taiwan
Authors: Huang Hsin-Hua
Published: July 2022

Taiwan is a hotbed of seismic and orogeny activity and this is the basis of the research of Dr Hsin-Hua Huang, Earth Structures Laboratory, Institute of Earth Sciences, Academia Sinica, Taiwan. He has illuminated detailed crustal and slab structures that have furthered understanding
of Taiwan orogeny, incorporated ambient noise data to resolve high-resolution imaging of the volcanic and fault structure in northern Taiwan and conducted research that led to the discovery of multi-layering magma beneath the Yellowstone supervolcano in the US. The ultimate goal of his diverse
studies is to achieve an improved imaging of the structure of the Earth and establish better understanding of the orogenic tectonic process and assess and mitigate natural hazards, such as volcanoes and earthquakes. In their latest project, Huang and the team are using the seismic wave interferometry
method, combined with Taiwan's existing real-time signal transmission Taiwan Broadband Seismic Network (BATS) and the Central Weather Bureau Seismic Network (CWB24), to develop an automated real-time seismicity change detection system. The idea is that by measuring changes in the transmission
velocity of seismic waves in the crust, physical parameters such as the degree of rock compression or changes in porosity can be linked and discussed. The researchers have performed an extensive review of knowledge about the current stage of fault zone failure and healing processes,the advantages
of seismic noise interferometry and the need for Taiwan fault zone monitoring and related seismic interferometry research. In order to understand the temporal changes in crustal structure and the behaviour of velocity changes across faults, a long-term and stable real-time seismic velocity
change monitoring system is necessary.
The year of the oceans and biodiversity
Authors: Annette Lucy
Published: July 2022

The oceans and climate are closely linked and climate change is threatening ocean health. Human activities are accelerating climate change and global warming is causing issues on land and in the sea. In February 2022, European Commissioner for the Environment, Oceans and Fisheries Virginijus
Sinkevičius delivered a press speech addressing this situation. Discussing the impact of the pandemic on the worsening climate situation he said: ‘We all have lost precious time to save our nature, our oceans, and to create more sustainable opportunities for citizens all around
the world.’ He highlighted the need for quick action and progression, stating: ‘We must move forward and we must do it fast.’ He also spoke of the progress of the European Green Deal and its potential to extend beyond Europe: ‘We are not only ambitioning to bring changes
within the EU, but also to lead by example and steer a global green transition.’ Underlining key focus for 2022, Sinkevičius said: ‘This year must be the year of the oceans. This year must be the year of biodiversity’. It is hoped that the Convention on Biological
Diversity’s (CBD) post-2020 Global Biodiversity Framework will be adopted at COP15. ‘We need a Paris moment for biodiversity. This is a top priority for the EU,’ Sinkevičius stated. ‘We want COP15 to be a genuinely transformative moment for biodiversity, and
this requires a strong political engagement from all at the highest level.’
The Data-Adaptive Fellegi-Sunter Model for Probabilistic Record Linkage: Algorithm Development and Validation for Incorporating Missing Data and Field Selection
Authors: Li Xiaochun , Xu Huiping , Grannis Shaun
Published: July 2022

Background

Quality patient care requires comprehensive health care data from a broad set of sources. However, missing data in medical records and matching field selection are 2 real-world challenges in patient-record linkage.

Objective

In this study, we aimed to evaluate the extent to which incorporating the missing at random (MAR)–assumption in the Fellegi-Sunter model and using data-driven selected fields improve patient-matching accuracy using real-world use cases.

Methods

We adapted the Fellegi-Sunter model to accommodate missing data using the MAR assumption and compared the adaptation to the common strategy of treating missing values as disagreement with matching fields specified by experts or selected by data-driven methods. We used 4 use cases, each containing a random sample of record pairs with match statuses ascertained by manual reviews. Use cases included health information exchange (HIE) record deduplication, linkage of public health registry records to HIE, linkage of Social Security Death Master File records to HIE, and deduplication of newborn screening records, which represent real-world clinical and public health scenarios. Matching performance was evaluated using the sensitivity, specificity, positive predictive value, negative predictive value, and F1-score.

Results

Incorporating the MAR assumption in the Fellegi-Sunter model maintained or improved F1-scores, regardless of whether matching fields were expert-specified or selected by data-driven methods. Combining the MAR assumption and data-driven fields optimized the F1-scores in the 4 use cases.

Conclusions

MAR is a reasonable assumption in real-world record linkage applications: it maintains or improves F1-scores regardless of whether matching fields are expert-specified or data-driven. Data-driven selection of fields coupled with MAR achieves the best overall performance, which can be especially useful in privacy-preserving record linkage.
Initial Psychometric Properties of 7 NeuroUX Remote Ecological Momentary Cognitive Tests Among People With Bipolar Disorder: Validation Study
Authors: Moore Raeanne C , Parrish Emma M , Van Patten Ryan , Paolillo Emily , Filip Tess F , Bomyea Jessica , Lomas Derek , Twamley Elizabeth W , Eyler Lisa T , Depp Colin A
Published: July 2022

Background

As smartphone technology has become nearly ubiquitous, there is a growing body of literature suggesting that ecological momentary cognitive testing (EMCT) offers advantages over traditional pen-and-paper psychological assessment. We introduce a newly developed platform for the self-administration of cognitive tests in ecologically valid ways.

Objective

The aim of this study is to develop a Health Insurance Portability and Accountability Act–compliant EMCT smartphone-based platform for the frequent and repeated testing of cognitive abilities in everyday life. This study examines the psychometric properties of 7 mobile cognitive tests covering domains of processing speed, visual working memory, recognition memory, and response inhibition within our platform among persons with and without bipolar disorder (BD). Ultimately, if shown to have adequate psychometric properties, EMCTs may be useful in research on BD and other neurological and psychiatric illnesses.

Methods

A total of 45 persons with BD and 21 demographically comparable healthy volunteer participants (aged 18-65 years) completed smartphone-based EMCTs 3 times daily for 14 days. Each EMCT session lasted approximately 1.5 minutes. Only 2 to 3 tests were administered in any given session, no test was administered more than once per day, and alternate test versions were administered in each session.

Results

The mean adherence to the EMCT protocol was 69.7% (SD 20.5%), resulting in 3965 valid and complete tests across the full sample. Participants were significantly more likely to miss tests on later versus earlier study days. Adherence did not differ by diagnostic status, suggesting that BD does not interfere with EMCT participation. In most tests, age and education were related to EMCT performance in expected directions. The average performances on most EMCTs were moderately to strongly correlated with the National Institutes of Health Toolbox Cognition Battery. Practice effects were observed in 5 tests, with significant differences in practice effects by BD status in 3 tests.

Conclusions

Although additional reliability and validity data are needed, this study provides initial psychometric support for EMCTs in the assessment of cognitive performance in real-world contexts in BD.
Randomized Controlled Trials of Artificial Intelligence in Clinical Practice: Systematic Review
Authors: Lam Thomas Y T , Cheung Max F K , Munro Yasmin L , Lim Kong Meng , Shung Dennis , Sung Joseph J Y
Published: July 2022

Background

The number of artificial intelligence (AI) studies in medicine has exponentially increased recently. However, there is no clear quantification of the clinical benefits of implementing AI-assisted tools in patient care.

Objective

This study aims to systematically review all published randomized controlled trials (RCTs) of AI-assisted tools to characterize their performance in clinical practice.

Methods

CINAHL, Cochrane Central, Embase, MEDLINE, and PubMed were searched to identify relevant RCTs published up to July 2021 and comparing the performance of AI-assisted tools with conventional clinical management without AI assistance. We evaluated the primary end points of each study to determine their clinical relevance. This systematic review was conducted following the updated PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) 2020 guidelines.

Results

Among the 11,839 articles retrieved, only 39 (0.33%) RCTs were included. These RCTs were conducted in an approximately equal distribution from North America, Europe, and Asia. AI-assisted tools were implemented in 13 different clinical specialties. Most RCTs were published in the field of gastroenterology, with 15 studies on AI-assisted endoscopy. Most RCTs studied biosignal-based AI-assisted tools, and a minority of RCTs studied AI-assisted tools drawn from clinical data. In 77% (30/39) of the RCTs, AI-assisted interventions outperformed usual clinical care, and clinically relevant outcomes improved with AI-assisted intervention in 70% (21/30) of the studies. Small sample size and single-center design limited the generalizability of these studies.

Conclusions

There is growing evidence supporting the implementation of AI-assisted tools in daily clinical practice; however, the number of available RCTs is limited and heterogeneous. More RCTs of AI-assisted tools integrated into clinical practice are needed to advance the role of AI in medicine.

Trial Registration

PROSPERO CRD42021286539; https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=286539
Women’s satisfaction with telehealth services during the COVID-19 pandemic: a cross-sectional survey study (Preprint)
Authors: Mittone Diletta , Bailey Caitlin P. , Eddy Ebony , Napolitano Melissa A. , Vyas Amita
Published: July 2022

BACKGROUND

Since March 2020, the need to reduce patients’ exposure to COVID-19 resulted in a large-scale pivot to telehealth service delivery. While studies report that pregnant women have been generally satisfied with their prenatal telehealth experiences during the pandemic, less is known about telehealth satisfaction among postpartum women.

OBJECTIVE

The present study examined telehealth satisfaction among both pregnant and recently pregnant women during the COVID-19 pandemic, to determine whether demographic factors (i.e., race, age, marital status, education level, household income, employment status) are associated with telehealth satisfaction in this population.

METHODS

A web-based cross-sectional survey designed to capture data on health-related behaviors and healthcare experiences of pregnant and recently pregnant women in the U.S. was disseminated in Spring 2022. Eligible participants were at least 18 years old, identified as a woman, were currently pregnant or had been pregnant in the last three years.

RESULTS

In the final analytic sample of N=403, the mean telehealth satisfaction score was 3.97±0.66 (score range 1-5). In adjusted linear regression models, being age 35-44 years (vs. 18-24 years), having an annual income of ≥100,000 USD (vs. <50,000 USD), and being recently (vs. currently) pregnant were associated with greater telehealth satisfaction (ps≤0.049).

CONCLUSIONS

Although perinatal women are generally satisfied with telehealth, disparities exist. It is critical that public health policies/programs consider these factors, especially if the expanded use of telehealth is to persist beyond the pandemic.
Omnichannel Communication to Boost Patient Engagement and Behavioural Change with Digital Health Interventions (Preprint)
Authors: Blasiak Agata , Sapanel Yoann , Leitman Dana , Ng Wei Ying , De Nicola Raffaele , Lee V Vien , Todorov Atanas , Ho Dean
Published: July 2022

UNSTRUCTURED

Digital health interventions (DHIs) are being increasingly incorporated into healthcare workflows to improve the efficiency of patient care. In turn, sustained patient engagement with DHIs can maximise their benefits towards healthcare outcomes. In this viewpoint, we outline a framework for dynamic patient engagement using various communication channels and the potential use of omnichannel engagement (OCE) to integrate these channels. We conceptualise a novel patient care journey where multiple online and offline communication channels are integrated through a ‘digital twin’. The principles of implementing OCE for DHI and digital twins are also broadly covered. OCE in DHI implies a flexibility for personalisation which can enhance and sustain patient engagement with DHI, and ultimately patient quality of care and outcomes. We believe the novel concept of OCE in healthcare can be greatly beneficial to the patients and the system once it is successfully realised to its full potential.
Landslide Susceptibility Mapping of Menoreh Mountain Using Logistic Regression
Authors: Sekarlangit Nadia , Fathani Teuku Faisal , Wilopo Wahyu
Published: July 2022

Menoreh mountain is one of the priority areas developed for tourism and to support sustainable development, it must pay attention to disaster aspects, one of which is landslides. The map published by Center for Volcanology and Geological Hazard Mitigation of Indonesia (PVMBG) has a regional scale, so it is necessary to have a more detailed landslide susceptibility map in the Menoreh Mountains. Identification and evaluation of the landslide conditioning factor were done using logistic regression so that the zonation of the probability of landslide susceptibility can be made. The data was used from field observation conducted at 372 locations including 129 locations where landslides occurred and from a local disaster management agency (BPBD) of 200 landslide locations. Significant landslide conditioning factors include slope, lithology, distance to lineaments, distance to river, and distance to road. The research area is divided into three susceptibility zones classified into low landslide susceptibility zone (0-0.33) covering 39.82%, moderate landslide susceptibility zone (0.34-0.66) covering 25.86%, and high landslide susceptibility zone (0.67-1.00) covering 34.31% of the whole area. Analysis using the logistic regression method has a model prediction accuracy rate of 90.5%, which means that it can predict landslide occurrence in the Menoreh Mountains accurately.
The Determination of Downhole Dynamic Compaction Paramaters Based on Finite Element Analysis
Authors: Wijaya Martin , Arsyad Ahmad Kemal , Lim Aswin , Rahardjo Paulus Pramono
Published: July 2022

Downhole dynamic compaction (DDC) has been commonly used in China to stabilize collapsible soil through the application of construction and demolition waste material (CDW). DDC basically forms a column inside the soil stratum which is similar to a stone column except DDC materials are put in sequence and then compacted by using DDC hammer. Due to its attractive features such as its big diameter, feasibility of using oversized material particles, rapid and simple construction technique, it is used as one of the ground improvement methods for an airport project in Indonesia. Despite of all the advantages provided by DDC, it is difficult to obtain DDC parameters from laboratory tests as it is difficult to replicate the compaction effort induced by the DDC hammer and laboratory tests are not commonly employed for oversized materials. Hence, alternative method is required to evaluate DDC parameters. In this study, static load test is conducted to determine load-deformation curve of the DDC pile. Soil parameters are first determined through soil test data such as standard penetration test (SPT), laboratory test and also pressure meter tests.  Correlation between pressure meter tests and SPT test result is also carried in order to interpret the soil parameter at the site. Axisymmetric finite element analysis is then carried by using MIDAS GTS NX in order to back analyses DDC parameters by matching the simulation curve with load settlement curve of the DDC. In this paper, it is shown that back analysis using hardening soil model for DDC material can be used to match simulation curve with the load-deformation curve.
RP-HPLC-METHOD DEVELOPMENT AND VALIDATION FOR THE SIMULTANEOUS ESTIMATION OF DEXKETOPROFEN TROMETAMOL AND TRAMADOL HYDROCHLORIDE IN PHARMACEUTICAL DOSAGE FORM
Authors: SUSMITHA P. , NEELIMA CH. , HEMASRI M. , LAKSHMI S. SRI
Published: July 2022

Objective: For the measurement and quantification of Dexketoprofen Trometamol and Tramadol Hydrochloride, a rapid, sensitive, and reliable RP-HPLC technique using the Waters HPLC System with PDA detection was designed and validated.

Methods: Chromatography was carried out on an Inertsil-ODS C18 (250 x 4.6 mm, 5) column with a flow rate of 1.0 ml/min and effluent of 240 nm using filtered and mixed Degassed Methanol: Buffer (75:25) v/v as a mobile phase.

Results: Dexketoprofen Trometamol and Tramadol hydrochloride has a retention time of 3.617 min and 5.013 min, respectively. % recovery for Dexketoprofen trometamol and tramadol hydrochloride was found to be 100.21% and 100.20%, respectively. LOD and LOQ values obtained for Dexketoprofen trometamol and tramadol hydrochloride are 0.074µg/ml, 0.225µg/ml and 0.175µg/ml, 0.531µg/ml respectively. Regression equation of Dexketoprofen trometamol is y = 7446.1273x-284.0702 and y = 39535.8782x-1580.4211 of Tramadol hydrochloride.

Conclusion: Dexketoprofen trometamol and tramadol hydrochloride has developed and validated in pharmaceutical dosage form using RP-HPLC method.
MOLECULAR DOCKING AND ADMET STUDIES OF BENZOTRIAZOLE DERIVATIVES TETHERED WITH ISONIAZID FOR ANTIFUNGAL ACTIVITY
Authors: AISWARIYA  , B. V. SUMA , SATYA MEDICHARLA SRI
Published: July 2022

Objective: The incidence of fungal infections is increasing at an alarming rate, presenting an enoromous challenge to health care professionals. This increase is directly related to the growing population of the immunocompromised individuals, resulting from changes in the medical practice such as the use of intensive chemotherapy and immunosuppressive drugs. The ability of many fungi to form biofilms is one of the reasons for the antifungal resistance caused and hence there is an urgent need in the synthesis of new and safer anti-microbial agnets. Benzotriazole is an organic heterocyclic compound with 2 nitrogen atoms in the ring having wide range of biological properties like anti-tubercular, anticancer and anti-microbial etc. isoniazid is the first line drug used to treat tuberculosis. Tethering benzotriazole with isoniazid has shown development of newer compounds that may exhibit better activity on inhibiting the fungal growth and replication and hence has shown a positive effect on the anti-fungal activity.

Methods: Affinity between the protein and ligand was found out using rigid docking technique.3D structure of the fungal protein was downloaded from protein data base. The selected ligand molecules are generated using Chem Draw. ADMET studies for the molecules are determined using SWISS-ADMET website. Rigid docking is employed to find the binding affinities between ligand and protein.

Results: 4 derivatives of benzotriazole tethered with isoniazid were selected and docking studies were carried out for these compounds with the antifungal protein,14 alfa-demethylase with PDB I. D; 5V5Z,using molecular docking tool PyRx and docking scores were-8.3,-7.6,-9.2,-7.4 respectively when compared with the standard compound Fluconazole (-8.0). ADMET studies of the 4 compounds have shown zero violation to lipinski’s rule.

Conclusion: In summary, benzotriazole derivatives tethered with isoniazid exhibits promising results based on in silico studies. ADMET studies showed that the compounds drug likeness parameters are according to lipinski’s rule of five.
The Khalimsky Line Topology- Countability and Connectedness
Authors: Bhuiyan S.A
Published: July 2022

The concepts of connectedness and countability in digital image processing are used for establishing boundaries of objects and components of regions in an image. The purpose of this paper is to investigate some notions of connectedness and countability of Khalimsky line topology.
Lidiar con la discriminación y la violencia sexuales en universidades alemanas: un inventario
Authors: Schüz Hannah-Sophie , Pantelmann Heike , Wälty Tanja , Lawrenz Nina
Published: July 2022

La discriminación y la violencia sexuales pueden encontrarse en todas las áreas de la sociedad, y las universidades no son la excepción. A menudo consideradas como espacios institucionales seguros, las universidades están lejos de haberse librado de estos problemas. Este artículo muestra la forma en que la violencia sexual desde hace mucho se ha vuelto tabú y se ha normalizado en el contexto universitario alemán, y la forma en que esto se refleja en el enfoque ambivalente que las universidades alemanas han mantenido sobre este problema. Con base en una evaluación de las formas en que las universidades encaran el problema en sus sitios web, así como en entrevistas telefónicas con expertas internas de las universidades, mostramos y discutimos la manera en que estas instituciones manejan el problema y su anclaje legal. Los resultados ayudan a identificar actores y prácticas relevantes, y aportan un punto de partida para el desarrollo de estrategias de acción a fin de mejorar el enfoque y el combate de la violencia sexual en las universidades.
Los actos de habla en la literatura: una propuesta operativa de la teoría al análisis textual
Authors: Rosanía Maza Nino Angelo , Coghi Andrea
Published: July 2022

El presente trabajo procura ser una contribución teórica a la pragmática de la comunicación literaria en su empresa por integrar el discurso literario en el mismo modelo básico del lenguaje natural que constituye el resto de las actividades de la comunicación humana. La perspectiva adoptada, como columna vertebral del ensayo, es la de Joseph Hillis Miller quien, al elaborar una crítica mordaz a Austin, permite plantear la posibilidad de utilizar la teoría de los actos de habla como una importante herramienta de análisis literario. En primera instancia, será presentado un esbozo de la ya conocida teoría de actos de habla de Austin. En la segunda parte, se sintetizarán una serie de dinámicas en las que las observaciones de Joseph Hillis Miller apuntan hacia una posible separación de los actos performativos —incluyendo los ilocutivos como parcialmente performativos— en forma de un tentativo esquema de sistematización. Finalmente, el último apartado, presentará una pequeña muestra de aplicación de estas categorías en un peculiar cuento del escritor catalán Enrique Vila-Matas, “Chet Baker piensa en su arte”, que se coloca provocativamente en el límite entre una prosa de ficción y un modelo de texto no-narrativo. El ejercicio analítico, tanto de la teoría como de su posible aplicación, servirá entonces para observar el poder revelador del género literario como parte imprescindible del estudio de la lengua.
A study on the relationship between parent-child interaction, young child’s emotional intelligence and ego resilience: focusing on the mediation effect of ego resilience
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Lee Jeong Ae
Published: July 2022

Objectives The purpose of this study is to examine the relationship between parent-child interaction and young child’s emotional intelligence and ego resilience and to examine the mediating effect of ego resilience.
Methods The subjects of this study were 244 children aged 4-5 years and one parent from J province and G city, and the data were analyzed using the SPSS 22.0 program. First, the correlation between parent-child interaction and young child’s emotional intelligence and ego resilience was examined. Next, the mediating effect of ego resilience in the relationship between parent-child interaction and young child’s emotional intelligence was analyzed.
Results As a result of the study, first, as a result of examining the correlation between parent-child interaction and young child’s emotional intelligence and ego resilience, it was found that there was a significant correlation between variables. In other words, there was a correlation between parent-child interaction and young child’s emotional intelligence, parent-child interaction and ego resilience, and there was a correlation between young child’s emotional intelligence and ego resilience. Second, as a result of examining the mediating effect of ego resilience in the relationship between parent-child interaction and young child’s emotional intelligence, it was found that ego resilience partially mediates the relationship between parent-child interaction and young child’s emotional intelligence. This can be explained by the fact that parent-child interaction not only directly affects the process of influencing the emotional intelligence of children, but also indirectly influences it through the medium of ego resilience.
Conclusions In conclusion, it suggests that more practical studies on effective parent-child interaction are needed to enhance young child’s emotional intelligence and ego resilience.
The Effects of Youth Activities and Self-esteem on the Academic Helplessness: Focusing on The Mediated Effect of Grit
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Go Yohan , Chung Hyewon
Published: July 2022

Objectives The purpose of this study is to explore the structural relationship of the effects of youth activities and self-esteem between the academic helplessness through the mediating effect of the grit of middle school students, and analyze the direct and indirect effects between variables.
Methods For this purpose, the 2020 survey data of the Korean Children and Youth Panel Survey 2018 (KCYPS 2018) were used, and 2,384 students for the 3th grade at middle school were selected for the study. The structural equation modeling was applied to the dataset.
Results The results are as follows: First, the youth activities and self-esteem had a negative effect on academic helplessness. In addition, the grit had a significant direct effect on academic helplessness. Second, the effect of youth activities on academic helplessness is futher strengthened by grit as a mediator. Finally, the effect of self-esteem on academic helplessness is futher strengthened by grit as a mediator.
Conclusions Based on these main results, it is necessary to recognize and improve the necessity of youth activities, self-esteem, and grit to lower academic helplessness. and provide various youth activities programs, self-esteem and grit promote program for middle school students.