bluuebunny/crossref_metadata_2025 huggingface dataset:
A novel rituximab administration protocol to minimize infusion-related adverse reactions in patients with B-cell non-Hodgkin lymphoma
Authors: Tsutsumi Daisuke , Hayama Tatsuya , Miura Katsuhiro , Uchiike Akihiro , Tsuboi Shinya , Otsuka Susumu , Hatta Yoshihiro , Kishikawa Yukinaga
Published: September 2021

Background

Rituximab is widely used as a key component of immunochemotherapy to treat B-cell non-Hodgkin lymphoma (B-NHL). However, infusion-related reactions (IRRs) during drug administration are occasionally severe or even life-threatening and thus remain problematic for patients and healthcare providers.
Aim

To minimize IRRs to rituximab in patients with various types of B-NHL.
Method:

We stratified patients into low- (n = 39), moderate- (n = 35), and high-risk (n = 7) groups according to the number of risk factors, specifically, an indolent histology and the presence of bulky tumors (> 10 cm). For the first rituximab cycle, the low- and moderate-risk groups underwent conventional infusion #1 (~ 4.3 h), and the high-risk group underwent long infusion (6.8 h). Patients in the low-, moderate-, and high-risk groups without IRRs in the first cycle underwent short infusion (2.3 h), conventional infusion #2 (3.5 h), and conventional infusion #1, respectively. Patients with IRRs in the first cycle received a second rituximab cycle with the same schedule as that in the first cycle. The procedure for the third cycle was at the attending physician’s discretion.
Results

Among 81 B-NHL patients, the incidences of IRRs in the low-, moderate-, and high-risk groups were 31%, 20%, and 57%, respectively, without any grade ≥ 3 IRRs. The overall conversion rate to short infusion in the third cycle was 54%, without any IRRs.
Conclusion

Our step-by-step protocol provided safe and comfortable rituximab administration for both patients and practitioners (UMIN-CTR; UMIN000032309, registered on 19th April 2018).
Advanced ventilatory support and mortality in hospitalized patients with COVID-19 caused by Gamma (P.1) variant of concern compared to other lineages: cohort study at a reference center in Brazil
Authors: Zavascki Alexandre Prehn , Vieceli Tarsila , Wink Priscila Lamb , Volpato Fabiana Caroline Zempulski , Monteiro Francielle Liz , Willig Julia Biz , Ferreira Charles Francisco , Arns Beatriz , Magalhães Guilherme Oliveira , Costa Matheus Niches , Martins Andreza Francisco , Barth Afonso Luís
Published: September 2021

Background

The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) variant of concern (VOC) Gamma (P.1) has increased transmissibility and resulted in elevated hospitalization, intensive care unit occupancy and mortality rates in Brazil. It is not known whether this VOC is also associated with more severe clinical course of disease.
Methods

This was a retrospective cohort study with non-elderly patients hospitalized for COVID-19 from June to December/2020 (first period) and February to May/2021 (second period) at a reference hospital in Brazil. Two cohorts were performed: the main cohort, composed by patients with SARS-CoV-2 lineages confirmed by whole genome sequencing; and the sensitivity cohort, composed by all eligible patients admitted before and after the emergence of Gamma. The primary outcome was the incidence rate of need of advanced ventilatory support.
Results

In the main cohort a total of 86 (43 Gamma and 43 non-Gamma) patients were included. Baseline characteristics were similar, except that Gamma patients had lower median Charlson’s comorbidity score. The crude and adjusted incidence rates of advanced respiratory support (adjusted Hazard Ratio [aHR], 1.78; 95% Confidence Interval [CI], 1.05–3.03), invasive respiratory support (aHR, 2.64; 95% CI, 1.34–5.19) and 28-day mortality from onset of symptoms (aHR, 4.73; 95% CI, 1.15–19.41) and adjusted 28-day mortality from hospital admission (aHR, 3.72; 95% CI, 1.19–11.65) were significantly higher in patients infected by Gamma. These patients had significantly lower days alive and free of supplemental oxygen support. The sensitivity cohort included 433 patients: 259 from the first and 174 from the second period (before and after the emergence of Gamma, respectively). Baseline characteristics were similar, except for a higher incidence of severe distress respiratory syndrome in patients from second group at admission. Patients from the second period had significantly higher incidence rates of advanced respiratory support (aHR, 2.04; 95% CI, 1.60–2.59), invasive ventilatory support (aHR, 2.72; 95%CI, 2.05–3.62), and 28-day mortality from the onset of symptoms (aHR, 2.62; 95%CI, 1.46–4.72).
Conclusions

Our study suggests that in non-elderly hospitalized patients, COVID-19 caused by Gamma VOC may present a more severe clinical course, with increased need of advanced respiratory support and higher 28-day mortality.
Molecular cytogenetics and St-chromosome-specific molecular markers development of novel stripe rust resistant wheat–Thinopyrum intermedium as well as wheat–Thinopyrum ponticum substitution lines
Authors: Wang Siwen , Wang Changyou , Feng Xianbo , Zhao Jixin , Deng Pingchuan , Wang Yajuan , Zhang Hong , Liu Xinlun , Li Tingdong , Chen Chunhuan , Wang Baotong , Ji Wanquan
Published: September 2021

Background
Owing to the excellent resistance to abiotic and biotic stress, Thionpyrum intermedium (2n = 6x = 42, JJJsJsStSt) and Thinopyrum ponticum (2n = 10x = 70) are both widely utilized in wheat germplasm innovation programs. Disomic substitution lines (DSLs) carrying one pair of alien chromosomes are valuable bridge materials for novel genes transmission, FISH karyotype construction and specific molecular marker development.
Results
Six wheat–Thinopyrum DSLs derived from crosses between Abbondanza nullisomic lines (2n = 40) and two octoploid Trititrigia lines (2n = 8x = 56), were characterized by a sequential fluorescence in situ hybridization (FISH)–genome in situ hybridization (GISH), a multicolor GISH (mc-GISH), and an analysis of wheat 15K SNP array combined with molecular marker selection. ES-9 (DS2St (2A)) and ES-10 (DS3St (3D)) are wheat–Th. ponticum DSLs, while ES-23 (DS2St (2A)), ES-24 (DS3St (3D)), ES-25(DS2St (2B)), and ES-26 (DS2St (2D)) are wheat–Th. intermedium DSLs. ES-9, ES-23, ES-25 and ES-26 conferred higher thousand-kernel weight and stripe rust resistance at adult stages, while ES-10 and ES-24 performed highly resistant to stripe rust at all stages. Furthermore, cytological analysis showed that the alien chromosomes (2St/3St) belonging to the same homoeologous group derived from different donors carried the same FISH karyotype and could normally form a bivalent. Based on specific-locus amplified fragment sequencing (SLAF-seq), two 2St-chromosome-specific markers (PTH-005 and PTH-013) and two 3St-chromosome-specific markers (PTH-113 and PTH-135) were developed.
Conclusions
The six wheat–Thinopyrum disomic substitution lines conferring stripe rust resistance will be used as bridging parents for valuable resistant genes transmission. And the utility of PTH-113 and PTH-135 in a BC1F2 population showed the newly developed markers could be useful tools for efficient identification of St chromosomes in a common wheat background.
Urbanization – changes in employment and incomes of people in Vietnam
Authors: Thuy Cu Thanh
Published: September 2021

This study aimed to analyze the impact of urbanization on the income and employment of people in Vietnam. To collect data for the study, 515 people participated in the survey, representing 515 households living in major cities in Vietnam. The OLS regression method and the T-test are applied to analyze the research objectives and examine the differences in the income and employment of people before and after urbanization. Research findings show that urbanization has both positive and negative effects on people’s income and employment in Vietnam. The income of people increased by about 12.5779 million VND/year compared to the pre-urbanization period. After urbanization, new jobs will increase, with employment disparities before and after urbanization in each family averaging about 1.734 jobs. The survey findings also show that household investments have the most significant influence on household income (standardized coefficients = 0.465). Compensation also has a positive and relatively substantial impact on household income with standardized coefficients = 0.195. However, the undesirable consequences of urbanization affected the employment of a part of the population, the number of unemployed leads to a decrease in the household’s income (standardized coefficients = –0.13).
Hoax Detection Program: Pendampingan Analisis Literasi Digital Konten Hoax untuk Majlis Taklim Muslimah di Jawa Tengah
Authors: Mundhir Mundhir , Djurban Djurban
Published: September 2021

Hoax dan fakta adalah dua hal yang berbeda tapi sering salah tebak. Keterbatasan informasi, identifikasi dan adanya keinginan berbagi informasi menjadi faktor utama hoax begitu mudah menyebar di tengah masyarakat. Majlis taklim muslimah di Jawa Tengah sebagai pusat kegiatan keagamaan ibu muslimah menjadi tempat diseminasi gagasan anti-hoax yang efektif karena selain menjadi forum kajian keagamaan dan spiritualitas, majlis taklim memiliki peran untuk penguatan persoalan sosial termasuk gerakan deteksi hoax. Proses pengabdian ini berlangsung dalam tiga tahap: assessment lapangan, FGD tentang literasi digital dan wawasan hoax, pelatihan dan pendampingan mengenai literasi digital untuk mendeteksi hoax serta tindak lanjut. Ada beberapa hasil dari pengabdian ini, antara lain subjek dampingan merupakan vulnerable communities dalam konteks informasi digital, dimana rentan usia didominasi 50-60 tahun yang memiliki kecakapan literasi digital rendah. Setelah program dampingan dilakukan, terjadi peningkatan kemampuan dalam proses deteksi hoax.
Peran Lembaga Pengabdian dan Pengembangan Masyarakat (LP2M) Pesantren Al-Luqmaniyyah Yogyakarta dalam Mengurangi Masalah Krisis Keagamaan di Masyarakat Pelosok
Authors: Asari Aang , Charismanto Charismanto
Published: September 2021

Penelitian ini berfokus pada salah satu kegiatan pengabdian yang telah terprogram setiap tahunnya di pondok pesantren Al-Luqmaniyyah Yogyakarta. Sasaran Pengabdian ini dikonsentrasikan pada daerah terpelosok yang dirasa masih membutuhkan pengembangan dan pemberdayaan. Khususnya mengenai pemahaman keagamaan masyarakat yang dinilai masih awam. Metode yang digunakan adalah metode kualitatif deskriptif. Penulis menceritakan hasil pengamatan dan pengalamannya serta dengan penelusuran dari data-data yang sudah didapat dari beberapa responden terkait. Pengambilan data pada penelitian ini menggunakan wawancara semi terstruktur dan observasi. Teknik analisis data dilakukan dengan cara reduksi data, penyajian data, dan penarikan kesimpulan. Hasil penelitian menunjukkan bahwa program tahunan Lembaga Pengabdian dan Pengembangan Masyarakat (LP2M) Pesantren Al-Luqmaniyyah yang dilaksanakan oleh santri-santri sebagai penggeraknya di lapangan, mampu untuk mengurangi krisis keagamaan di masyarakat. Selain itu pula dampak yang dirasakan masyarakat selaku objek dan santri sebagai subjek dari Lembaga Pengabdian dan Pengembangan Masyarakat ini bisa dirasakan oleh seluruh pihak terkait. Lembaga pengabdian dan pengembangan pondok pesantren ini juga masih tetap eksis dari awal berdiri hingga saat ini. This research focuses on one of the yearly programmed service activities at the Al-Luqmaniyyah Yogykarta Islamic boarding school. This Community Service target focuses on remote areas that still need development and empowerment. Especially regarding the religious understanding of the community which is still common. The method used is descriptive qualitative method. The author tells the results of his observations and experiences and also presents the results of tracing data obtained from several related respondents. The data collection process in this research used semi-structured interviews and observations. The data analysis technique was carried out by means of data reduction, data presentation, and drawing conclusions. The results showed that the annual program of the Institute for Community Service and Development (LP2M) of Al-Luqmaniyyah Islamic Boarding School which was implemented by the students as a driving force was able to reduce the religious crisis in society. In addition, the impact felt by the community as objects and students as subjects of this Community Service and Development Institute can be felt by all parties involved. This institution also still exists today.
Improving the ZnO-photocatalytic degradation of humic acid using powdered residuals from water purification plant
Authors: Elmougi Mohamed , El-Etriby Hisham , Barakat Ragab , Alalm Mohamed Gar , Mossad Mohamed
Published: September 2021

Alum residuals were collected from a water treatment plant and used for improving the photocatalytic degradation of humic acid (HA) by combinations of zinc oxide (ZnO) and powdered residuals from a water purification plant (PRWPP). The influence of operating conditions such as initial humic acid concentration, pH, irradiation time, PRWPP to ZnO ratio, catalyst dose, and light illuminance have been investigated. The optimum PRWPP to ZnO ratio was 10:90. Using the prepared composites instead of bare ZnO raised the HA removal efficiency from 85.5% to 97.8%, and from 38% to 48.1% at catalyst doses of 1.2 g/l and 0.4 g/l, respectively. Moreover, it reduced energy consumption from 210.4 to 166.2 Wh per mg of HA. An artificial neural network model (ANN) was developed to predict the removal efficiency under different operating conditions. The optimum ANN structure yielded a coefficient of determination (R2 = 0.993). A modified Langmuir-Hinshelwood pseudo-first-order model was used for describing the degradation kinetics at different initial concentrations of HA.
Optimization of pipeline lifecycle cost using alternatives with different life spans
Authors: Elsebaie Ibrahim H. , Al-Khomairi Abdulrahman
Published: September 2021

This paper suggests a pipeline project optimization approach that compares alternatives with different life spans. The average inflation rate is used to project the future maintenance, operation and replacement costs. The average interest rate is used to express all the costs in Equivalent Real Annual Cost (ERAC), which is the correct cost form to compare alternatives with different life spans. The pipe diameter, material, pressure rating, surge tank size, and inlet/outlet resistances are the decision variables. A software was compiled with a commercial pipeline software to generate all the possible design alternatives based on the decision variables. Pipe initial cost as well as operation and maintenance costs are computed for each design alternative. The alternative with the least ERAC value is the optimum one. It was found that the approach can lead to substantial savings in pipeline projects cost. For pipes 800 mm in diameter or larger, and when selecting the optimum diameter, savings are between 23 and 27% in the total project cost. When imposing certain pipe material savings in overall cost will be 8.5, 16.3 and 31.3% for ductile iron, GRP and mild steel pipe material, respectively.
Interactions between ACE2 and SARS-CoV-2 S Protein: Peptide Inhibitors
for Potential Drug Developments Against COVID-19
Authors: Dërmaku-Sopjani Miribane , Sopjani Mentor
Published: September 2021

:

Angiotensin-converting enzyme (ACE) shares some homologies with ACE2. However,
they are not inhibited by the same inhibitors, but both are associated primarily with the hypertensive
disorder through the renin-angiotensin system (RAS). The principal activity of ACE2 is to metabolize
Ang II into the vasodilatory Ang-(1-7). The ongoing COVID-19 pandemic caused by the
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has brought the ACE2 to the center
of attention. This coronavirus uses the host cell ACE2 protein to enter and infect the epithelial
cells. In light of the virus's entrance into human cells, the differences in the molecular basis of
ACE2 among affected patients may cause their different responses to the virus. Many details about
the specific interaction between the viral S protein and ACE2 are already reported. To date, some
effective clinically approved vaccines are in use globally, and many others are under development,
but no effective specific therapeutic drugs are available against COVID-19. Inhibitors, especially
peptide inhibitors, have a great potential to be used for the treatment of COVID-19 and other possible
emerging diseases caused by viral pathogens. As a result of the well-known viral protein structures
and their host cell targets such as ACE2, antiviral peptides could be appropriately designed
and optimized for therapeutic purposes. A better understanding of the structure and pathophysiology
of the ACE2 receptor and the interplay between the viral S protein and ACE2 may help to find
the solution for the virus treatment. This review summarizes the current understanding of S protein
interaction with the ACE2 protein as a potential specific target against SARS-CoV-2 and strategies
using peptides against COVID-19.
[18F] Fluorothymidine Positron Emission Tomography Imaging in Primary Brain Tumours: A Systematic Review
Authors: Matteucci Federica , Guglielmo Priscilla , Quartuccio Natale , Rossetti Virginia , Celli Monica , Alongi Pierpaolo , Boero Michele , Arnone Gaspare , Baldari Sergio , Laudicella Riccardo
Published: September 2021

Purpose:

This review aimed to summarize the available literature on the clinical application
of [18F] FLT PET imaging in primary brain tumours.

Methods:

A comprehensive search strategy based on Pubmed/Medline, Scopus, Web of Science,
Cochrane Library, Google Scholar, and the Embase databases was carried on using the following
search string: ('3` Fluorothymidine'/exp OR 'FLT' OR '[18F]-FLT' OR '[18F] Fluorothymidine')
AND ('pet'/exp OR 'pet' OR 'positron emission tomography') AND ('glioma'/exp OR 'glioma' OR
'brain tumour'/exp OR 'brain tumour’). The search was updated till March 2021 and only articles in
English and studies investigating the clinical applications of [18F] FLT PET and PET/CT in primary
brain tumours were considered eligible for inclusion.

Results:

The literature search ultimately yielded 52 studies included in the systematic review, with
main results as follows: a) the uptake of [18F] FLT may guide stereotactic biopsy but does not discriminate
between grade II and III glioma. b) [18F] FLT uptake and texture parameters correlate
with overall survival (OS) in newly diagnosed gliomas. c) In patients with recurrent glioma, proliferative
volume (PV) and tumour-to-normal brain (T/N) uptake ratio are independent predictors of
survival. d) Patients demonstrating response to therapy at [18F] FLT PET scan show longer OS compared
to non-responders. e) [18F] FLT PET demonstrated good performance in discriminating tumour
recurrence from radionecrosis. However, controversial results exist in comparative literature
examining the performance of [18F] FLT vs. other radiotracers in the assessment of recurrence.

Conclusion:

[18F] FLT PET imaging has demonstrated potential benefits for grading, diagnostic
and prognostic purposes, despite the small sample size studies due to the relatively low availability
of the radiotracer.
Imaging Findings for Identifying and Evaluating Complications After
Lung Transplantation in Patients with Advanced COVID-19: Two Case
Reports
Authors: Chen Feng , Pan Junhan , Zhu Manhua , Han Weili
Published: September 2021

Background:

Lung transplantation might be a viable alternative for patients with irreversible
lung injury secondary to coronavirus disease 2019 (COVID-19). Here, we describe two patients
with end-stage COVID-19 that received lung transplantations, the clinical-radiologic manifestations
of postoperative complications, and the imaging features of allograft rejection.

Case presentation:

In case 1, a 66-year-old woman presented severe hypoxia after lung transplantation.
Chest imaging revealed diffuse homogeneous infiltration in the donor's lung. Dramatic resolution
of the imaging abnormalities after intravenous administration of methylprednisolone favored a
diagnosis of hyperacute rejection. The second is a 70-year-old man who was infected with bacterial
postoperatively. During the empiric antibiotic therapy, chest CT showed newly developed groundglass
opacities with septal thickening, suggesting a diagnosis of acute rejection. High-dose corticosteroids
therapy was initiated, and the patient recovered gradually.

Conclusion:

This is the first report describing postoperative complications of lung transplantation
in patients with advanced COVID-19. We presumed that imaging procedures could be a useful tool
in early detecting lung transplant complications and selecting specific interventions for patients
with COVID-19.
Molecular Docking and Dynamics Simulation of Natural Phenolic Compounds with GSK-3β: A Putative Target to Combat Mortality in Patients with COVID-19
Authors: Khamverdi Zahra , Mohamadi Zeinab , Taherkhani Amir
Published: September 2021

Objective:

In this study, molecular docking analysis was performed to evaluate the binding
affinity of 52 plant-based phenolics with the GSK-3β active sites. Moreover, Molecular Dynamics
(MD) simulation was conducted to investigate the stability of interactions between the topranked
phenolics and residues within the GSK-3β active sites.

Methods:

Molecular docking and MD simulations were performed using AutoDock and Discovery
Studio Client software, respectively. Thereafter, pharmacokinetic and toxicological properties of
top inhibitors were predicted using bioinformatics web tools. This study aimed to identify the most
effective amino acids involved in the inhibition of GSK-3β based on the most stabilizing interactions
between the residues and compounds, and also by considering the degree centrality in the ligand-
amino acid interaction network for GSK-3β.

Results:

It was observed that procyanidin and amentoflavone could bind to the GSK-3β active sites
at the picomolar (pM) scale as well as the binding affinity of ΔG binding < -13 kcal/mol, while the inhibition
constant for theaflavin 3’-gallate, procyanidin B4, and rutin was calculated at the nanomolar
(nM) scale, suggesting that these phenolic compounds can be considered as potential effective
GSK-3β inhibitors. Furthermore, Val70, Ala83, Val135, and Tyr134 were found to be the most important
amino acids involved in the inhibition of GSK-3β.

Conclusion:

The results of the current study may be useful in the prevention of several human disorders,
including COVID-19, cancers, Alzheimer’s disease, diabetes mellitus, and cardiovascular
diseases. However, wet-lab experiments need to be performed in the future.
Use of Lip Protecting Agents in the Prevention of Actinic Cheilitis, Herpes Labialis and Cancer of Lip: A Systematic Review
Authors: Moon So Hyun , Sangha Amolak , Ravichandran Malavika , Samuela Amy Vicki , Tso Stephanie , Sharma Dileep , Ariyawardana Anura
Published: September 2021

Background:

Actinic cheilitis, herpes labialis and lip cancer are relatively common conditions presenting on the lips associated with exposure to periods of sun exposure and thereby ultraviolet radiation.

Objective:

This systematic review aimed to determine the efficacy of the application of sunscreen-containing lip-protecting agents (LPA) in the prevention of actinic cheilitis (AC), recurrent herpes labialis (RHL) and lip cancer (LC).

Methods:

This review was conducted in accordance with the PRISMA guidelines and registered with the PROSPERO database. A literature search was conducted using SCOPUS, Google Scholar, Medline (Ovid), Pubmed, CINAHL, Cochrane Library databases and manual search using search terms actinic cheilitis (AC), recurrent herpes labialis (RHL) and lip cancer (LC) along with lip protecting agents and their variations as keywords. A total of 1,567 papers were yielded. Of them, nine studies were eligible for qualitative data synthesis.

Results:

Nine articles (3 AC, 5 RHL, 1 LC) were deemed eligible and thus selected for qualitative synthesis. Three studies on AC identified approximately 21.7% lower prevalence of lesions when some form of lip protection was used. Eighty percent of studies on RHL identified that the application of LPA is effective in preventing RHL. Subjects who applied LPA more than once daily only had half the risk of having LC compared to those who applied once daily.

Conclusion:

This review of randomised controlled trials (RCTs) and observational studies supports the use of LPA as an effective method in preventing lip-associated lesions. Further, RCTs and observational studies should aim at determining a definitive LPA application regime and optimal SPF strength to prevent lip-associated lesions.

This systematic review was registered with the International Prospective Register of Systematic Reviews (PROSPERO): Registration Number - CRD42020177484. https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42020177484
Endodontic Treatment versus Implant Placement for Compromised Teeth: Decision-Making Trends in Saudi Arabia
Authors: Bahabri Rayan , Borzangy Sary , Taymour Nevine , Maddhar Abdulrahman , Alkayyal Mahmod , Alhazmi Walaa , Taher Sarah
Published: September 2021

Background:

The decision to save a compromised tooth is a major challenge among dentists and may vary among those with different areas of specialization.

Objective:

The objective of this study was to determine the influencing factors that play a role in decision-making trends when choosing whether or not to save a compromised tooth, either through endodontic treatment or extraction and implant placement.

Methods:

In this cross-sectional study, a questionnaire was administered to a convenience sample to assess decision-making within different dental specialties among various dental schools in Saudi Arabia. Participants were stratified into four groups based on clinical specialties, including endodontists (n = 45, 23.9%), periodontists (n = 51, 27.1%), prosthodontists (n = 55, 29.3%), and oral and maxillofacial surgeons (n = 37, 19.7%). The data of 188 participants were analyzed using Chi-square tests, with significance at p ≤ 0.05.

Results:

Endodontists were significantly more likely than other specialists (p ≤ 0.002) to decide to retain a compromised tooth rather than place an implant. In difficult prosthetic cases, faculty surgeons were significantly more likely to place an implant than other specialists (p ≤ 0.01).

Conclusion:

The assessment of decision-making trends demonstrated that retention of the natural tooth by endodontic and restorative treatments was preferred over extraction and implant placement. Increased prosthetic complexity shifted this preference towards implant placement. This study provides a basis to help identify factors contributing to decision-making among dental professionals; these factors could improve existing guidelines to ensure a successful practice.
Usefulness of Hard Palate Measurements in Predicting Airway Dimensions in Patients Referred for Cone Beam CT
Authors: Alkhader Mustafa , Alrashdan Mohammad S. , Abdo Nour , Abbas Rashed
Published: September 2021

Purpose:

The aim of the study was to evaluate the usefulness of hard palate measurements in predicting airway dimensions in patients referred for cone-beam CT (CBCT).

Materials and Methods:

Six hundred forty-three patients (239 males and 404 females) were examined by CBCT. Using dedicated CBCT software (Kodak CS 3D imaging version 3.8.6, Carestream, Rochester, NY, USA); different hard palate (palatal interalveolar length, palatal arch depth, maxillo-palatal arch angle, and alveolar width) and airway measurements (airway volume, minimum cross-sectional area, minimum anteroposterior distance, minimum right to left distance and airway length) were obtained and correlated using Pearson’s correlation coefficients and regression analysis.

Results:

Although the correlation between hard palate and airway measurements was weak (Pearson coefficient (r) < 0.40), there were significant (P < 0.05) additive effects for hard palate measurements in predicting airway dimensions. Maxillo-palatal arch angle was the only hard palate measurement that had no effect in predicting airway dimensions.

Conclusion:

Hard palate measurements are considered useful in predicting airway dimensions in patients referred for CBCT.
Comparison of Biocompatibility of Experimental Tricalcium Phosphate Cement versus Biodentin and Mineral Trioxide Aggregate used for Furcation Perforation Repair (in vivo study)
Authors: El-Bialy Mostafa M. , Ali Magdy M. , Kataia Engy M. , El Nemr Reham S. , Hassan Reham
Published: September 2021

Background:

The interaction between the root canal system and the oral cavity caused by iatrogenic perforations significantly affects the treatment outcome and tooth survival.

Objectives:

This study was directed to compare the biocompatibility of an experimental tricalcium phosphate cement versus biodentine and mineral Trioxide aggregate used for furcation perforation repair in dogs.

Methods:

Perforations were done in 60 teeth (premolars and molars) of six adult dogs. Animals were divided randomly into 3 equal groups of 2 animals each according to the post-operative evaluation period of 1 week, 1 month, and 3-months. Each group was further subdivided into 4 subgroups according to either being repaired with the experimental tricalcium phosphate cement (n=6), or Biodentine (n=6), Mineral Trioxide Aggregate (MTA) (n=6), and positive control(n=2). After evaluation periods, tissue blocks were harvested and histologically examined.

Results:

No statistically significant difference was found regarding bone deposition scores and inflammatory reaction in the three groups after 1 week, 1 month, or 3 months. All three groups showed a statistically significant difference between all three time periods. Regardless of the repair material used, inflammation scores at 1-week showed the highest scores, decreasing over time except for the control group.

Conclusion:

The experimental material could be considered as a successful treatment option for repairing furcation perforation.
Current Phytochemical and Pharmacological Outlook of Actinidia
deliciosa (Kiwi Fruit)
Authors: Siddiquie Saman , Ahmad Md. Afroz , Ahsan Farogh , Mahmood Tarique , Arif Muhammad , Khushtar Mohammad , Islam Anas
Published: September 2021

:

Worldwide health and therapeutic practices seek to amalgamate alternative medications with
evidence-based medicine for an improved understanding of metabolic progression and its influences on
the human body. Actinidia deliciosa, also known as “Kiwi fruit”, is a dioecious plant that is native to
China and distributed widely across the Asian continent. Commercial planting of kiwifruit was started
in the early 20th century when it reached New Zealand from China. In recent times, Kiwi fruit has
gained a major demand due to its high content of vitamin C. Kiwi fruit also contains dietary fiber, iron,
carotenoids and is a rich source of antioxidants. These may aid in lowering blood pressure, improve
wound healing, blood glucose control and improve bowel health. Vitamin C, choline, lutein, and zeaxanthin
are antioxidants that assist in the removal of free radicals from the body and may prevent the
body from various diseases and inflammations. Herein, we state the health benefits found in diverse
compounds from Actinidia deliciosa, highlighting the source, morphology, chemical constituent, cultivation,
production, traditional uses, nutritional value, health benefits, toxicity studies, clinical trials,
and pharmacological activities while highlighting side effects associated with kiwifruit. This review
provides a bird’s eye insight mainly on the morphological, phytochemical, and pharmacological activity,
which could be beneficial in making use of technological and scientific advances. This plant can be
used as a current medical adjuvant for its potential. The complete plant must be broadly investigated
for further future perspective.
THE STRUGGLE OF THE SOVIET AUTHORITY AGAINST THE «REMNANTS OF UNIAT» IN THE UKRAINIAN SSR AT THE BREAK OF THE 1970s – 1980s
Authors: PUYDA ROMAN
Published: September 2021

The key methods of the Ukrainian SSR party authorities to counter the attempts of reviving the Ukrainian Greek Catholic Church in the western Ukrainian regions at the break of the 80s-90s of the XX century were considered. It was noted that in the late 1970s in this region, particularly in Galicia, Greek-Catholic believers and the clergy measurably intensified their activity, which was evident mainly in houses of worship attendance, traditional rites observance, letters issued to the Council for Religious Affairs of the Soviet Union Ministers with the requirement to register religious communities, clandestine ordination of the clergy, etc. It was stated that in order to counter the religious influence intensification of the Russian Orthodox Church on the population, as well as to prevent negative anti-social manifestations of «remnants of Uniat», local Communist Party committees and Soviet authorities carried out a number of propaganda and mass political events to expose anti-Soviet religious ideology, in particular, «the reactionary role of the Uniat Church in the history of the Ukrainian people». It was noted that the Communist Party of Ukraine took concrete measures to step up anti-religious propaganda in Western Ukrainian regions, as well as to promote the advantages of the Soviet mode of life. It was alleged that the activities of Greek Ca¬tholic believers were discussed at the Council for Religious Affairs of the Soviet Union Ministers sessions of the Ukrainian SSR in the regions of Western Ukraine, party rallies at different levels, meetings of the ideological activists of the regions, seminars of cultural and educational wor¬kers, district and regional atheist conferences. It was noted that the Communist Party of Ukraine paid considerable attention to the media, which should have covered the historical aspects of the «anti-popular backbone of Uniat Church».
Атомарная люминесценция Ag при однопузырьковом сонолизе водной суспензии наночастиц серебра
Authors: Гареев Б.М. , Шарипов Г.Л.
Published: September 2021

For the first time, luminescence of Ag atoms was recorded during moving single-bubble sonolysis of silver nanoparticles aqueous colloidal suspension. This glow is caused by the entry of nanoparticles into a bubble deformable during motion and their decomposition to atoms with collisional excitation in the nonequilibrium plasma of the bubble. Nanoparticles were obtained by multibubble sonolysis of an AgNO3 solution with the addition of honey. This method was used to synthesize a stable suspension of Ag nanoparticles with an average size of ~ 10 nm. By comparing the experimental spectrum of this suspension and simulated spectra of Ag, the electron temperature in the bubble plasma was found to be ~ 10000 K.
Влияние отверстий в пористой поверхности земли на парящий полет насекомого
Authors: Zhou Xinping , Huang Yong
Published: September 2021

Aerodynamics of a flapping foil at low Reynolds number in close proximity to the ground in aperture effect are studied by numerical simulations based on the normal hovering motion mode. A vortex street is interestingly generated by both ground and aperture effects and the rotation of the foil. The study reveals that the aperture takes a force-reduction effect and a large enough aperture effectively can remove the ground force-enhancement effect produced when the foil is in close proximity to the ground. This paper provides an effective method of optimizing foil-flapping flight design of flying robotics over a porous plane.
Telemedicine During A Crisis: Challenges, Opportunities & Way Forward At A Tertiary Care Hospital (Preprint)
Authors: Masood Sadia , Samad Zanaib , Nadeem Sarah , Ghulam Unzela
Published: September 2021

BACKGROUND

Telemedicine is utilized to deliver health care services remotely. Recently, it is well established due to pandemics because it can help the patients get required supportive care while minimizing their hospital exposure. In the future, it will continue to be used as a convenient, cost-effective patient care modality.

OBJECTIVE

The objectives were to identify physicians' challenges during teleconsultations and recognize the opportunities and strengths of this modality during the pandemic in a lower-income country.

METHODS

This cross-sectional study was conducted in a tertiary care hospital. The self-made questionnaire was filled through an online medium and responses were recorded on a five-point Likert scale.

RESULTS

A total of 83 participants were enrolled in this study. Most of them were Associate professors (29.8%), Assistant professors (26.2%), the ratio of the females was (52.4%) greater than males (,47.6%). 46 (54.8%) have laid between the age group 30-40 years. Pediatricians and senior instructors faced more difficulty in using telemedicine. The ones having clinical experience of fewer than 15 years or categorized in the age of 50-60 years faced challenges while using this modality.

CONCLUSIONS

During the current pandemic, situation telemedicine is the only glimmer of light to provide better quality health care. Telemedicine is an innovative strategy and it is important to understand the perception of physicians about it. Incomplete and inadequate infrastructure and attitude of the physicians is the main obstacle toward successful implementation of telemedicine. Successful installation and deployment of this technology require a complete grasp of the process among physicians.
Kesempurnaan sebagai Orientasi Keilmuan dalam Teosofi Suhrawardi Al-Maqtul
Authors: Suryosumunar John Abraham Ziswan , Kuswanjono Arqom
Published: September 2021

Knowledge and science are central issues in epistemological debates. The paradigm of knowledge will imply on the methods and means that are used to achieve truth. The social contexts which influence the tradition of thought have also a strong impact on the construction of scientific paradigms. Different social contexts is the reason why the western and eastern scientific paradigms are considered to have different characteristics. In the tradition of eastern thought there are various opinions on scientific paradigm. One of which is from the perspective of Suhrawardi Al-Maqtul. By using the hermeneutic method, the author attempts to answer the question how is the concept of science and its characteristics from the perspective of Suhrawardi and what are the methods and the orientation of science that used by the perspective of Mazhab Al-Isyraqiyyah that Suhrawardi Al-Maqtul created.  The paper proposes that the concept of science in Suhrawardi’s thought resulted from syncretism of various previous eastern thoughts. Suhrawardi understood the plurality of methods that can be used, namely the burhani method with ratio and evidence, as well as the irfani method that comes from intuition. The method must be suitable for the objects of study, which is Suhrawardi’s, encompasses not only aspects of the physical world but also the non-physical supra-worldly. The orientation of this thought is not only to achieve the validity of knowledge but to achieve the perfection of knowledge or the transformation from the dark to the light of knowledge.
Repackaging Nitrite-Embedded Dark-Cutting Steak in Aerobic Polyvinyl Chloride Film Decreases Surface Redness
Authors: Denzer Morgan L. , Mafi Gretchen G. , VanOverbeke Deborah L. , Ramanathan Ranjith
Published: September 2021

The overall goal was to evaluate the effects of repackaging nitrite-embedded dark-cutting steaks in polyvinylchloride (PVC) film on surface color. Dark-cutting beef strip loins (n = 8; pH = 6.39) and USDA Low Choice beef strip loins (USDA Choice, n = 6; pH = 5.56) were selected at a commercial packing plant. Dark-cutting loins were bisected and randomly assigned to nonenhanced dark-cutting and enhanced dark-cutting with glucono delta-lactone and rosemary treatments. USDA Choice and nonenhanced dark-cutting steaks were vacuum packaged (VP) and served as controls, whereas enhanced dark-cutting steaks were packed in nitrite-embedded packaging (NP). Steaks from nonenhanced USDA Choice VP, nonenhanced dark-cutting VP, and enhanced dark-cutting NP loins were randomly assigned to 3, 6, or 9 d of dark storage.Following dark storage, steaks were repackaged in PVC and displayed for 6 d at 2°C. Instrumental color, visual color, and aerobic plate count were evaluated for all steaks. Enhanced dark-cutting steaks in NP increased (P < 0.05) a* values compared with USDA Choice and nonenhanced dark-cutting VP during 24 h of dark storage. Enhanced dark-cutting steaks packaged in NP had greater a* and L* values (P < 0.05) than nonenhanced dark-cutting VP steaks during dark storage. Upon repackaging the enhanced dark-cutting steaks from NP, nitric oxide myoglobin decreased (P < 0.05) during the first 12 h of display. Loss of nitric oxide myoglobin corresponds with a darker red appearance, increased surface discoloration, and decreased a* values.There were no differences (P > 0.05) in aerobic plate count between enhanced dark-cutting NP steaks and nonenhanced dark-cutting VP steaks after repackaging. In conclusion, NP improved surface redness; however, repackaging enhanced dark-cutting from NP steaks in PVC decreased color stability and redness of dark-cutting beef.
Human-Computer Interactions: The Importance of Usability
Authors: Harshith Paidakula
Published: September 2021

Abstract: The tremendous technological advancement that has endured through the last century to the present has led to more good than harm. Ranging from vast technological devices to information communication technology (ICT), which have become the new methods of communication, exchange of knowledge, collaboration, and innovation among users and organizations, life is getting more efficient. The technological devices, including mobile devices, systems application software, and websites, continue impacting lives positively. However, it is reckoned that there is a dearth of essential functionalities and utilities, particularly the Human-Computer Interaction (HCI) and usability. These are essential ingredients in any of these devices since they allow the computer users to take as little time as possible to complete their tasks while achieving high efficient performance. Key Terms: HCI, ICT, Usability, Website,
ANALYSIS OF TUMOR DETECTION USING UNETS AND VGG16 WEIGHTS
Authors: Kakulapati V
Published: September 2021

Tumor detection from Brain MRI images Abstract: Detecting tumors in the human brain has become the most challenging medical science issue. Recognition of tumors in MRIs is vital as it offers the aberrant relevant data for therapeutic interventions. MRI includes details on malignant tissue. An abnormal tissue growing and multiplying in the brain is a brain tumor. Physical examination is the standard approach for brain tumor identification, which takes much time and is not accurate every time. So, automated brain tumor identification methods are establishing to save time. Image segmentation utilizes to detect the brain's abnormal portion, which gives the tumor's location. This work uses the UNETS with VGG16 weights model to see and segment tumors from the rest of the brain tissue. The accurate detection of the tumors helps reduce the delay between diagnostic testing and therapy. Therefore, there is a significant demand for computer algorithms to be precise, speedy, time-efficient, and dependable. The technology described relates to detecting and analyzing brain cancers automatically via U-Net and the VGG16 CNN.
ACTIVE RELEASE TECHNIQUE AND ITS IMPACT ON NON-SPECIFIC LOW BACK PAIN
Authors: Vaidya Laukik
Published: September 2021

Non-specific low back pain (NLBP) or "simple backache" is characterized as an LBP not due to any identifiable disease such as nerve root pain and severe spinal pathologies such as infection, tumour, osteoporosis, rheumatoid arthritis, fracture or inflammation. Myofascial Trigger Points in skeletal muscles, identified with a hypersensitive palpable nodule or "knot" in the middle of the muscle belly, are described as hyperirritable. Active Release Technique (ART) is a non- invasive soft tissue restoration procedure that includes reducing the scar tissue that would induce discomfort, stiffness, muscle weakness and unusual pain like mechanical dysfunction of the myofascial and soft tissue. A 23 years old inert, after assisting in a lot surgery started with a low back pain which increased gradually. Activities like bending forward as well as backward, standing for long time, and unsupported sitting for long time which relieved on rest. She took paracetamol as the pain started, which relived her pain. In this case report, a 23 years old intern, who had non-specific low back pain was successfully rehabilitated and was able to resume her activities withing a few days which was followed for a month which was painless as well. ART proved helpful along with hot fomentation and core strengthening exercises to reduce her pain. In this case report, a 23 years old intern, who had non-specific low back pain was successfully rehabilitated and was able to resume her activities withing a few days which was followed for a month which was painless as well. ART proved helpful along with hot fomentation and core strengthening exercises to reduce her pain.
REHABILITATION OF A CONSERVATIVELY MANAGED CLAVICULAR FRACTURE
Authors: Wadhokar Om C
Published: September 2021

The collarbone, or wishbone, is a thin, S-shaped bone about 6 inches (15 cm) long and serves as a support between the shoulder blade and the sternum (sternum). Clavicle fracture so occur as a result of injury or trauma. The most common site of fracture is the junction between the two curvatures of the bone, which is the weakest point. The displacement post fracture is most common in clavicular fracture because the attachment of the muscle sternocleidomastoid pulls the Sternal head upwards and the pectoral muscle pulls the distal clavicle downwards. After a distal clavicle fracture, radiographic nonunion has been identified in 10% to 44% of patients. Most of clavicular fractures are managed non-surgically by physical therapy which consists of a rehabilitation program without hampering the fracture healing, the rehabilitation consists of pain reduction, improving strength and range of motion of the shoulder, Scapular and neck muscles and postural correction exercises in addition to a brace to support the upper limb as the clavicle is the bone connecting the Axilla to the shoulder girdle. And the patient is started with medical management which usually consist of analgesics. 62 year old male patient with left clavicle fracture was diagnosed on x-ray after a hit from a bullock cart. Following this incident the patient underwent a prompt series of physical rehabilitation which included strengthening exercises, thoracic expansion exercises, breathing exercises. The case report suggests that a physiotherapy treatment procedure led to the improvement of functional goals progressively and significantly.