bluuebunny/crossref_metadata_2025 huggingface dataset:
Modeling vulnerability and intervention targets in the Borderline Personality Disorder system: A network analysis of in silico and in vivo interventions
Authors: Jiménez Said , Arango de Montis Iván , Garza-Villarreal Eduardo A.
Published: July 2023

Modeling psychopathology as a complex dynamic system represents Borderline Personality Disorder (BPD) as a constellation of symptoms (e.g., nodes) that feedback and self-sustain each other shaping a network structure. Through in silico interventions, we simulated the evolution of the BPD system by manipulating: 1) the connectivity strength between nodes (i.e., vulnerability), 2) the external disturbances (i.e., stress) and 3) the predisposition of symptoms to manifest. Similarly, using network analysis we evaluated the effect of an in vivo group psychotherapy to detect the symptoms modified by the intervention. We found that a network with greater connectivity strength between nodes (more vulnerable) showed a higher number of activated symptoms than networks with less strength connectivity. We also found that increases in stress affected more vulnerable networks compared to less vulnerable ones, while decreases in stress revealed a hysteresis effect in the most strongly connected networks. The in silico intervention to symptom alleviation revealed the relevance of nodes related to difficulty in anger regulation, nodes which were also detected as impacted by the in vivo intervention. The complex systems methodology is an alternative to the common cause model with which research has approached the BPD phenomenon.
Cohort profile: The Corona Behavioral Unit cohort, a longitudinal mixed-methods study on COVID-19-related behavior, well-being and policy support in the Netherlands
Authors: van den Boom Wijnand , van Dijk Mart , Snijders Bianca , Luijben Guus , van der Laan Jan , Euser Saskia , Sanders Jet G. , Buitenhuis Anne H. , Spruijt Pita , Kroese Floor , Lambooij Mattijs , Muhren Yvette , Tak Nannah , van der Swaluw Koen , van Rossum Caroline , Nielen Thijs , Elberse Janneke , Renes Reint Jan , Leurs Mariken , de Bruin Marijn
Published: July 2023

This ‘cohort profile’ aims to provide a description of the study design, methodology, and baseline characteristics of the participants in the Corona Behavioral Unit cohort. This cohort was established in response to the COVID-19 pandemic by the Dutch National Institute for Public Health and the Environment (RIVM) and the regional public health services. The aim was to investigate adherence of and support for COVID-19 prevention measures, psychosocial determinants of COVID-19 behaviors, well-being, COVID-19 vaccination, and media use. The cohort also examined specific motivations and beliefs, such as for vaccination, which were collected through either closed-ended items or open text responses. In April 2020, 89,943 participants aged 16 years and older were recruited from existing nation-wide panels. Between May 2020 and September 2022, 99,676 additional participants were recruited through online social media platforms and mailing lists of higher education organizations. Participants who consented were initially invited every three weeks (5 rounds), then every six weeks (13 rounds), and since the summer of 2022 every 12 weeks (3 rounds). To date, 66% of participants were female, 30% were 39 years and younger, and 54% completed two or more questionnaires, with an average of 9.2 (SD = 5.7) questionnaires. The Corona Behavioral Unit COVID-19 cohort has published detailed insights into longitudinal patterns of COVID-19 related behaviors, support of COVID-19 preventive measures, as well as peoples’ mental wellbeing in relation to the stringency of these measures. The results have informed COVID-19 policy making and pandemic communication in the Netherlands throughout the COVID-19 pandemic. The cohort data will continuously be used to examine COVID-19 related outcomes for scientific analyses, as well as to inform future pandemic preparedness plans.
Shibboleth: An agent-based model of signalling mimicry
Authors: Goodman Jonathan R. , Caines Andrew , Foley Robert A.
Published: July 2023

Mimicry is an essential strategy for exploiting competitors in competitive co-evolutionary relationships. Protection against mimicry may, furthermore, be a driving force in human linguistic diversity: the potential harm caused by failing to detect mimicked group-identity signals may select for high sensitivity to mimicry of honest group members. Here we describe the results of five agent-based models that simulate multi-generational interactions between two groups of individuals: original members of a group with an honest identity signal, and members of an outsider group who mimic that signal, aiming to pass as members of the in-group. The models correspond to the Biblical story of Shibboleth, where a tribe in conflict with another determines tribe affiliation by asking individuals to pronounce the word, ‘Shibboleth.’ In the story, failure to reproduce the word phonetically resulted in death. Here, we run five different versions of a ‘Shibboleth’ model: a first, simple version, which evaluates whether a composite variable of mimicry quality and detection quality is a superior predictor to the model’s outcome than is cost of detection. The models thereafter evaluate variations on the simple model, incorporating group-level behaviours such as altruistic punishment. Our results suggest that group members’ sensitivity to mimicry of the Shibboleth-signal is a better predictor of whether any signal of group identity goes into fixation in the overall population than is the cost of mimicry detection. Thus, the likelihood of being detected as a mimic may be more important than the costs imposed on mimics who are detected. This suggests that theoretical models in biology should place greater emphasis on the likelihood of detection, which does not explicitly entail costs, rather than on the costs to individuals who are detected. From a language learning perspective, the results suggest that admission to group membership through linguistic signals is powered by the ability to imitate and evade detection as an outsider by existing group members.
The transcriptome of HTLV-1-infected primary cells following reactivation reveals changes to host gene expression central to the proviral life cycle
Authors: Aristodemou Aris E. N. , Rueda David S. , Taylor Graham P. , Bangham Charles R. M.
Published: July 2023

Infections by Human T cell Leukaemia Virus type 1 (HTLV-1) persist for the lifetime of the host by integrating into the genome of CD4+T cells. Proviral gene expression is essential for proviral survival and the maintenance of the proviral load, through the pro-proliferative changes it induces in infected cells. Despite their role in HTLV-1 infection and a persistent cytotoxic T lymphocyte response raised against the virus, proviral transcripts from the sense-strand are rarely detected in fresh cells extracted from the peripheral blood, and have recently been found to be expressed intermittently by a small subset of cells at a given time.Ex vivoculture of infected cells prompts synchronised proviral expression in infected cells from peripheral blood, allowing the study of factors involved in reactivation in primary cells. Here, we used bulk RNA-seq to examine the host transcriptome over six daysin vitro, following proviral reactivation in primary peripheral CD4+T cells isolated from subjects with non-malignant HTLV-1 infection. Infected cells displayed a conserved response to reactivation, characterised by discrete stages of gene expression, cell division and subsequently horizontal transmission of the virus. We observed widespread changes in Polycomb gene expression following reactivation, including an increase in PRC2 transcript levels and diverse changes in the expression of PRC1 components. We hypothesize that these transcriptional changes constitute a negative feedback loop that maintains proviral latency by re-deposition of H2AK119ub1 following the end of proviral expression. Using RNAi, we found that certain deubiquitinases,BAP1,USP14andOTUD5each promote proviral transcription. These data demonstrate the detailed trajectory of HTLV-1 proviral reactivation in primary HTLV-1-carrier lymphocytes and the impact on the host cell.
Book review: Mellado Blanco, C. (Ed.). (2021). Productive Patterns in Phraseology and Construction Grammar: A Multilingual Approach
Authors: Pazos Bretaña José Manuel
Published: July 2023

Book review: Mellado Blanco, C. (Ed.). (2021). Productive Patterns in Phraseology and Construction Grammar: A Multilingual Approach.
Reseña del libro: Dal Maso, Elena. (2019): Fraseología y metáforas zoomórficas, estudio de la equivalencia funcional entre español e italiano
Authors: Lei Chunyi
Published: July 2023

Reseña del libro: Dal Maso, Elena. (2019): Fraseología y metáforas zoomórficas, estudio de la equivalencia funcional entre español e italiano.
Reseña del libro: Martín, L. (2022). Bestiari medieval
Authors: Martínez Pérez Miguel
Published: July 2023

Reseña del libro: Martín, L. (2022). Bestiari medieval.
El pretérito perfecto compuesto en los manuales de español de nivel B1: análisis crítico
Authors: Bustos Gisbert José Manuel
Published: July 2023

Pese a su complejidad formal y a su formidable variedad diatópica, el pretérito perfecto compuesto (PPC) es un contenido presente en los métodos de enseñanza de español como lengua extranjera desde los primeros niveles de aprendizaje. Este trabajo ha querido evaluar la presencia del PPC, en su variante peninsular estándar, en los métodos de enseñanza publicados en España desde 2011 correspondientes al nivel B1, según lo describe el Marco Común Europeo de Referencia para las lenguas. En primer lugar, se ha analizado la presencia del PPC en las fuentes principales en las que sus autores parecen sustentarse: la Nueva Gramática de la Lengua Española (NGLE), que usamos gramática normativa de referencia, y el Plan Curricular del Instituto Cervantes (PCIC). En segundo lugar, se ha valorado críticamente la presencia de contenidos relativos al PPC en diecisiete métodos de enseñanza de ELE publicados en España. Se ha identificado una serie de limitaciones derivadas de la escasa aplicación de las directrices del PCIC y de un planteamiento conceptual globalmente impreciso, resultado de sugerir ciertos contenidos que no quedan perfectamente claros y que heredan inconsistencias observadas en la NGLE. A partir de ello se ha realizado una propuesta orientada a facilitar la explicación del PPC en el nivel B1. Primero, se ofrece una nueva interpretación del significado general del PPC; para ello el presente deja coincidir con el momento del habla y pasa a ser entendido como un segmento que se prolonga, o puede prolongarse, antes y después de ese punto: el PPC se emplea para expresar acciones acaecidas en el segmento previo al momento de la elocución. En segundo término, se revisa el verdadero rendimiento de los marcadores temporales en el uso del PPC según el entorno textual y se valora cuáles son los más empleado en el uso real. Por último, se propone la inclusión de variables vinculadas a la tipología textual en la explicación del uso del PPC.
La dependencia sintáctica y la correlación temporal como valores definitorios de las formas verbales en la enseñanza del español como lengua extranjera. El caso del pretérito perfecto de subjuntivo
Authors: García Manga María Carmen
Published: July 2023

En el presente trabajo se analizará pormenorizadamente cómo aspectos como la dependencia sintáctica, la equivalencia temporal entre indicativo y subjuntivo o la correlación establecida entre la expresión del denominado estilo indirecto y el discurso diferido se convierten en características definitorias de la forma haya cantado en obras dedicadas a la enseñanza-aprendizaje de español a extranjeros. Se analiza un corpus de 55 gramáticas y manuales de ELE, en el que constataremos cómo se plantea su tratamiento didáctico a partir del análisis, entre otros aspectos, de la variación terminológica de sus denominaciones, las definiciones y la ejemplificación empleada. En este sentido, los objetivos concretos de este trabajo son: (1) Analizar el tratamiento de la forma haya cantado en el corpus. Se presta especial atención a aspectos como la dependencia sintáctica y la equivalencia o correlación temporal entre indicativo y subjuntivo, en tanto que definitorios de la forma objeto de estudio. (2) Revisar la variación terminológica y conceptual existente. (3) Examinar las relaciones que las distintas obras que constituyen el corpus establecen, en cada caso, entre la forma haya cantado y otras formas. Teniendo en cuenta que el pretérito perfecto de subjuntivo es, en muchas ocasiones, definido como forma verbal que se usa para referirse a una acción concluida en el presente o el futuro, su carácter relacional hace necesario el establecimiento de interconexiones con otros tiempos verbales y otros elementos presentes en el discurso. Como resultado del estudio realizado, se comprueba, no solo la caracterización como forma verbal dependiente y correlativa, sino también la escasa carga metalingüística existente en gramáticas y manuales de ELE en relación con la forma objeto de estudio, muy especialmente en manuales pertenecientes al enfoque comunicativo. Partimos del hecho de que en la enseñanza-aprendizaje del español es imprescindible atender a la forma (Long 1991 y 1997), por lo que el conocimiento lingüístico en general, y de la gramática de las formas verbales en particular, redundará de forma determinante en los resultados del proceso formativo. La reflexión metalingüística se constituye, así, en uno de los pilares básicos de ELE (Pastor Cesteros 2005). Así, la presente contribución se plantea como objetivo último ayudar al profesorado y alumnado de ELE en la selección de manuales y gramáticas en relación con la enseñanza del sistema verbal del español, contribuyendo, en última instancia, a la valoración de las ventajas teóricas y aplicadas en la didáctica de la forma estudiada.
¿Quién hablará de las muertas? Resistiendo al olvido desde los ensamblajes narrativos feministas
Authors: González Calvo Nerea , Amann Alcocer Atxu
Published: July 2023

Las investigaciones de género en ocasiones se ocupan de las muertas que han sufrido en sus cuerpos la violencia extrema por su simple condición de mujeres. Los estudios feministas a menudo ponen en el centro de la historia a las numerosas víctimas del horror del sistema cis-hetero-patriarco-colonialista, que han sido ignoradas e invisibilizadas sistemáticamente. A través de sus redes, realizan una labor de denuncia activa, dando voz, honrándolas y planteando propuestas creativas más que humanas, que se enfrentan críticamente a la necropolítica normalizada (Mbembe, 2011). La mayoría de las prácticas desarrolladas se pueden entender como ecologías tecnoartesanales, que superponen cuerpos, tiempos y espacios; son frecuentemente posproducciones experimentales que exploran, seleccionan y reúnen diversos materiales con el fin de cocrear nuevos objetos. Una de estas prácticas cotidianas narrativas más significativas es la de los collages, entendidas como un caso particular de los ensamblajes. Enfocándonos en los objetivos, en el caso específico de las prácticas destinadas a la reparación, los conjuntos de artefactos que resultan, de algún modo resignifican los espíritus de las muertas: quienes durante mucho tiempo fueron censuradas y sometidas por la lógica del dominio consciente, ahora son espectros cooptados, absorbidos por la lógica sistémica de la muerte, que mediante las prácticas reparadoras, logran su emancipación como sujetos políticos. Este artículo entre un estado del arte y un manifiesto, aborda con urgencia la siguiente cuestión: ¿quién hablará de las muertas? Reconoce la investigación sobre la práctica que indaga en la memoria y la reparación en clave de género, mirando al pasado, para intervenir en el olvido y revisitar la historia; interpela el presente de hacer-con (Haraway, 2019), como un futuro cercano posible, ético y más que humanamente vivible.
Synthesis, Characterization and Biological Evaluation of Novel Methoxy Benzaldehyde Substituted Derivatives of Pyrazolopyrimidine-4-hydrazide
Authors: Mansuri Rubeena , Badekar Raj , Jhalora Priyanka
Published: July 2023

Several novel pyrrolopyrimidine derivatives of methoxybenzaldehydes with biologically active pyrrole moieties were synthesized to investigate their antibacterial, antifungal and cytotoxic activities. Elemental analysis, UV-spectra, FT-IR, 1H NMR and 13C NMR spectra, were used to characterize the synthesized compounds. The in vitro antifungal and antibacterial activities were tested for all the synthesized compounds. Compared to the reference drugs e.g. fluconazole and streptomycin, most of the compounds tested positive for antifungal and antibacterial activity. All tested compounds demonstrated superior cytotoxic activity to the reference drug doxorubicin, with IC50 values ranging from 6.52 to 7.77 mM and comparable activity with IC50 values of 8.21 and 8.27 mM, respectively. In vitro antibacterial and antifungal activities revealed that the compouds b and e were more effective than the standard drugs streptomycin and fluconazole, respectively.
Ethnobotanical Uses, Phytochemistry, Biological Potential and Structural Modification of Himachalane Present in Cedrus deodara: A Mini Review
Authors: Kour P. , Sohal H.S. , Sharma R.
Published: July 2023

Cedrus deodara, often known as “deodara,” is native to the Western side of the Himalayas. It is a medicinal herb, with a wide range of pharmacological activities that have proven to be beneficial in treating various health problems. The demand for essential oils is growing at a rapid pace. The leaves and wood of Cedrus deodara contain a variety of essential oils. The three components are α-himachalene, β-himachalene and γ-himachalene. Cedrus deodara essential oils have more applications, particularly in stress-related diseases. The main purpose is to collect and report all the essential information about various Himachalene in Cedrus deodara. An exhaustive literature search was undertaken to construct this study, utilizing linked publications published in various journals. This mini review’s findings compile the chemical modification and synthesis of different Himachalene in Cedrus deodara. This study brings together and gives an up-to-date evaluation of important sesquiterpenes isolated from cedar essential oil, a family of plentiful and accessible natural materials.
Fabrication of Eco-friendly Hybrid Active Imidazole based Ionic Liquid Embedded Cadmium Oxide-TiO2 Catalyst for Photoelectrocatalytic and Hydrophobic Properties
Authors: Sudhalakshmi J. , Rajathi K.
Published: July 2023

In this work, a new and straightforward method for the synthesis of 1-hexyl-3-methyl-2-(2-oxo-ethyl)-3H-imidazol-1-ium bromide (HMIB) embedded on CdO-TiO2 (HMIB-CT) hybrid material is reported. The efficiency of the catalytically active material HMIB-CT with nanostructures is entirely depend on the preparation method. The X-ray diffraction patterns revealed that the anatase phase of titanium dioxide results in the formation of well-crystallized CdO and ionic liquid. The optical absorbance spectra demonstrated that the energy gap is diminished from 2.80 to 2.37 eV, which happens due to the presence of ionic liquids. The HR-TEM study shows that the particles are present in spherical shape, while some particles are rod structures with small amount of agglomeration found in imidazole based ionic liquid embedded CdO-TiO2 nanoparticles. The photoluminescence emission results also indicated that ionic liquids efficiently supported and blocked the recombination of charge carriers. A complete demineralization of an organic dye (Trypan blue) under natural sun beam irradiation required for the photocatalytic activity is also accomplished. Moreover, the prepared ionic liquid supported CdO-TiO2 hybrid material shows better electrocatalytic activity upon methanol oxidation (4.89 mA) and super hydrophobic nature by contact angle measurement (112.2º).
Recent Accounts of Green Catalysts for Biodiesel Production: A Mini Review
Authors: Kuladeep Aluru Sai , Bilval Chiragni , Pathak Aaditya Narayan , Khan Md Zahir , Kumar Prashant
Published: July 2023

Problems with solid waste management have become increasingly pressing in recent years. For some time now, it has been a major contributor to soil pollution, making the use of these materials in a variety of industrial applications an urgent necessity. Our search for replacement fossil fuels for transportation has been prompted by their diminishing availability. Biodiesel is one such alternative that doesn’t require any adjustments to diesel vehicles. In this study, we studied the efficiency and reusability of several green catalysts used in the production of biodiesel.
Synthesis, Spectral and Theoretical Characterization and Antimicrobial and Cytotoxic Studies of Some Transition Metal Complexes of 4-[(2E)-2-Benzylidenehydrazinyl]-7H-pyrrolo[2,3-d]pyrimidine
Authors: Dhanmane Sushilkumar , D'souza Melwin , Badekar Raj , Kadu Arun
Published: July 2023

Present work describes the synthesis and characterization of complexes of 4-[(2E)-2-benzylidenehydrazinyl]-7H-pyrrolo[2,3-d]pyrimidine with Fe(II), Mn(II), Co(II), Ni(II), Pd(II), Zn(II), Cu(II), Cd(II) and Hg(II). The results of the elemental and spectroscopic analyses suggest a 1:2 metal-ligand ratio, [ML2]. The electronic spectra and magnetic moments of the metal(II) complexes suggest that Fe(II), Mn(II), Co(II) and Ni(II) complexes are in an octahedral geometry, while Pd(II) in a square planar ligand geometry. In contrast, the Cu(II), Zn(II), Cd(II) and Hg(II) are in tetrahedral geometry. The conductance measurements in nitrobenzene suggest the non-electrolytic nature of all the metal-coordination compounds. The tested biological species viz. Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, Bacillus cereus, Proteus mirabilis, Klebsiella oxytoca, Aspergillus niger, A. flavus and Rhizopus stolonifer exhibited the moderate to strong antimicrobial activity. At 10 mg/mL concentration in nitrobenzene, cobalt(II) complex is observed to be a more promising antimicrobial than any other metal(II) complexes synthesized. The antioxidant potential of the synthesized metal(II) compounds was also evaluated using 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging assay and shows the high DPPH radical scavenging activity. The nickel complex had the highest DPPH radical scavenging activity compared to the other metal(II) complexes.
DFT, NBO, Fukui Functions and Monte Carlo Studies on Quinoline Derivatives for Corrosion Inhibition Property
Authors: Charles A. , Gopi C. , Jose P. Adwin , Ponsadailakshmi S.
Published: July 2023

The corrosion inhibiting property of 4-methylquinoline (4MQ) and 4-aminoquinaldine (4A2MQ) by using various quantum mechanical and molecular mechanics parameters such as EHOMO, ELUMO, energy difference (ΔEgap), electrophilicity, nucleophilicity, chemical hardness, chemical softness, adsorption energy on the metal surface, ability of back donation, electron affinity, chemical potential and dipole moment values are studied. Density functional studies were carried out using B3LYP/6-31g++(d,p), B3LYP/6-31g(d,p) and B3LYP/6-31g(d) basis sets. The outputs of the compounds were compared as well as the characteristics of the Fukui functions used to analyze them. The adsorption energy values were obtained using Monte Carlo simulation techniques. The adsorption energy calculations were carried out by using COMPASS force field and adsorption annealing methods. These calculated values had good agreement with previously reported values of these corrosion inhibitors. Comparing the combined dual descriptor values of 4MQ and 4A2MQ reveal that the latter compound readily undergoes electrophilic attack, leading to the enhanced corrosion inhibition. The efficiency of these corrosion inhibitors compounds by various studies was compared and the result shows that 4A2MQ can be better corrosion inhibitor than 4MQ.
Fasting Lipid Profile as a Predictor of Mortality and Morbidity in Dengue Hemorrhagic Fever
Authors: Rajalakshmi Kandasamy Venkatraju  , Boopathy Rajan Padmanabhan  , Bathragiri Marasamy
Published: July 2023

BACKGROUND

Dengue is a tropical disease which is a major cause of preventable mortality. It is essential to identify people who are at risk for progression to dengue hemorrhagic fever and dengue shock syndrome. Hence the search for an optimal biomarker which can identify patients at risk of progression to severe dengue is on. Some studies have indicated hypolipidemia to be a marker for the identification of critically ill patients. This study intended to find out the relationship between fasting lipid profile and dengue mortality and morbidity.

METHODS

This was a comparative cross-sectional study conducted for 1 year at a Government hospital setup with a sample size of 132.

RESULTS

Out of the 132 patients, all patients had bleeding manifestations ranging from purpuric rashes to melena. 92 patients had capillary leak syndrome and 52 patients developed shock. Most of the patients who developed bleeding manifestations, capillary leakage and shock were found to have hypocholestrolemia and HDL<50mg/dl.

CONCLUSIONS

It can be concluded that serum fasting lipid profile is an easily accessible and affordable indicator for early identification of patients at risk of progression to severe dengue.
Spectrum of symptoms and disease severity in COVID-19 breakthrough infections among vaccinated individuals.
Authors: Khan Dr. Mohammed Faraaz
Published: July 2023

The poster basically entails the various symptoms which patients of post vaccination covid infections (breakthrough infections) experience and their relative frequencies. As this study was done in India from April 2021 to October 2021, the symptoms presenting in the patients would most likely be attributable to the Delta variant of SARS CoV - 2 which was circulating in the community at the aforementioned time.
Aplicação de Intervenções Comportamentais para o Compliance Sanitário para Prevenção da COVID-19 em Ambiente Hospitalar
Authors: Leme Guilherme Atanazildo , Nasser Henry , Brazão Vasco , Serafim Milena Pavan , Vilas-Boas Vanessa Aparecida , Leite Juliana Arruda , Mauro Carlos
Published: July 2023

O presente artigo é fruto da pesquisa “Behavioral Insights Aplicados ao Compliance Sanitário”, realizada em um hospital de ensino público, especializado em saúde da mulher. Buscou-se aplicar behavioral insights para promover o uso de máscaras; o distanciamento social e a higienização das mãos da população que frequentava o local. O estudo tem caráter exploratório, de natureza quantitativa e cunho descritivo-analítico. Os resultados mostram que não houve indício de relação estatisticamente significante entre o número de ocorrências pré e pós-intervenções para os três comportamentos selecionados. A despeito da significância estatística, os resultados deste estudo contribuem para o conhecimento no tema, na medida em que podem ser levados em consideração para o design de futuros experimentos.
Perspectivas do Uso de Croton lechleri: Revisão Sistemática na Prevenção do Envelhecimento Cutâneo
Authors: Rossi Jéssica , Souza Sabrina Pires de , Machado Karina Elisa
Published: July 2023

A busca da fonte da juventude faz parte da história do homem, na verdade o mito vem associado ao desejo de não envelhecer, de não apresentar os sinais e sintomas do envelhecimento, neste contexto, destaca-se a diminuição das fibras de colágeno e elastina, que podem ser consideradas as principais responsáveis por esses sinais e sintomas. Atualmente, graças aos avanços tecnológicos e cosméticos, em partes, este desejo pode ser alcançado. Entre os vários ativos cosméticos, oriundos de plantas medicinais, utilizadas para esta finalidade pode-se destacar a espécie Croton lechleri, conhecida popularmente como sangue-de-dragão, sangue-de-drago ou sangre-de-grado. Nesta perspectiva, o presente estudo teve por objetivo, analisar os mecanismos de ação de C. lechleri, na prevenção do envelhecimento cutâneo, através de uma revisão sistemática descritiva, com abordagem qualitativa. Os resultados demonstraram que a espécie C. lechleri, apresenta diversas propriedades, entre as quais se podem destacar as ações anti-inflamatória, antioxidante, cicatrizante e reparadora do tecido cutâneo, atividades que estão relacionadas com a sua composição. Em conjunto, essas ações fazem com que a C. lechleri apresente como uma promissora agindo no processo rejuvenescedor, atuando não só na prevenção do envelhecimento, mas também na recuperação da derme e epiderme.
Atividade Física e Obesidade na Infância: Uma Revisão Integrativa
Authors: Cé Jean Augusto , Zanoni Eliton Marcio , Carvalho Risoní Pereira Dias de , Kades Gabriela , Fin Gracielle , Silva Bruna Becker da , Alberti Adriano
Published: July 2023

Introdução: a obesidade é considerada um problema de saúde pública, por se tratar de uma doença crônica que está aumentando consideravelmente, principalmente entre crianças e adolescentes, acarretando uma série de complicações e agravos a saúde. Objetivo: analisar  produções científicas sobre atividade física e obesidade na infância, publicadas no Brasil entre janeiro de 2018 a dezembro de 2019. Metodologia: Trata-se de uma revisão integrativa da literatura que consiste em agrupar e sintetizar conhecimentos já existentes sobre o tema. Foram utilizados estudos publicados baseados em evidências e que relacionam a atividade física e obesidade na infância, com a finalidade de sintetizar resultados de pesquisas já realizadas, além de apontar lacunas do conhecimento para realização de novos estudos.   Resultados: a obesidade envolve diversas disciplinas, como nutrição, medicina, psicologia e educação física. Através das aulas de Educação Física, os professores podem colaborar com a educação em saúde orientando quanto aos cuidados com a saúde e assim agir como parceiros dos programas preventivo-educativos. Cabe também ao professor e a escola encaminhar e conscientizar os alunos sobre a importância da aquisição de um estilo de vida ativo e hábitos saudáveis, buscando incentivar a prática de atividades físicas na infância, a fim de reduzir o sedentarismo e em consequência reduzir as altas taxas de obesidade. Conclusão: atividade física desempenha papel importante como fator de prevenção e redução do excesso de peso no tratamento da obesidade, pois associando a atividade física e a implementação de programas interdisciplinares irá auxiliar na melhor qualidade de vida das crianças e adolescentes.
A Educação Superior nos Governos de Lula e de Bolsonaro: Uma análise a partir dos programas de governo
Authors: Lima Helder Cassiel Ramos de Brito , Barbosa Julianderson de Araujo Barros , Oliveira Pablo Ricardo Passos , Santos Marcelo Henrique Pereira dos
Published: July 2023

O presente artigo pretende fazer uma análise sobre o contexto da educação nos governos do Presidente Luiz Inácio Lula da Silva, primeiro e segundo mandatos (2003-2010), e no governo do Presidente Jair Messias Bolsonaro (2019-2022), bem como a respeito das perspectivas sobre o terceiro mandato (2023-2026) do Presidente Lula. Partindo da hipótese de que o governo do ex-presidente Bolsonaro promoveu um retrocesso no âmbito educacional, com desmontes, cortes de gastos e insuficiência de investimentos, pretende-se identificar as políticas educacionais dos governos Lula, sua aplicação efetiva e os resultados obtidos. O trabalho utilizou a análise bibliográfica e documental. O principal foco foi o ensino superior, com ampliação e facilitação do seu acesso durante os governos de Lula e, com a deterioração do orçamento aplicado e desinteresse em investimentos e políticas públicas direcionadas à Educação Superior no governo Bolsonaro.
FGTS: Direito do Trabalhador e Instrumento de Política Pública Operacionalizado pela Caixa Econômica Federal
Authors: Souza Maria Auxiliadora Alves de , Souza Vanessa Espírito Santo Cavalcante de , Santos Marcelo Henrique Pereira dos
Published: July 2023

Pelo presente artigo pretende-se, através da revisão de literatura e análise de registro de dados públicos disponíveis no site da Caixa Econômica Federal (CEF), analisar o Fundo de Garantia Por Tempo de Serviço (FGTS) enquanto direito do Trabalhador e instrumento relevante para subsidiar a execução de políticas públicas. Ademais, visa inferir o alinhamento do fundo consoante os objetivos da Agenda 2030, pacto internacional subscrito pelo Brasil e traçado pelas Organizações da Nações Unidas (ONU) que visa erradicar pobreza, fome, falta de acesso aos serviços públicos e proteger o meio ambiente. O artigo mostra que além de direito e fonte de subsídios, o FGTS recentemente também foi utilizado como meio de injeção econômica dado o cenário decorrente do COVID 19. Para a análise foi resgatada a história da criação do FGTS, adentrando posteriormente nas hipóteses mais recentes de saques, além da caracterização da CEF como agente público gestor do fundo.
O Papel das Tecnologias Assistidas no Processo de Alfabetização de Alunos com Necessidades Especiais
Authors: Paulino Idelzuite Maria de Sousa , Pinheiro Filho Isac Sales
Published: July 2023

A pesquisa teve como objetivo analisar o impacto das práticas de alfabetização, letramento e educação inclusiva no processo de aprendizagem de alunos com necessidades especiais. Para isso, foram investigadas as principais abordagens e metodologias utilizadas, avaliando o papel da educação inclusiva na promoção da igualdade de oportunidades educacionais e identificando os desafios enfrentados. A metodologia adotada envolveu revisão bibliográfica e análise de estudos empíricos relacionados ao tema. Os resultados revelaram a importância de estratégias personalizadas, como o uso de práticas multissensoriais e tecnologias assistivas, bem como o trabalho colaborativo entre educadores, familiares e profissionais especializados. A educação inclusiva foi destacada como um fator crucial para garantira igualdade de oportunidades e a promoção do pleno desenvolvimento dos alunos com necessidades especiais. No entanto, foram identificados desafios, tais como a falta de recursos adequados e a necessidade de formação e capacitação dos professores. Recomenda-se a implementação de políticas inclusivas, a oferta de formação docente direcionada à educação inclusiva e a disponibilização de recursos adequados. Essas ações são essenciais para promover uma educação inclusiva de qualidade, garantindo o sucesso no processo de alfabetização e letramento dos alunos com necessidades especiais.
Prevalence of and factors associated with extraintestinal manifestations and their remission in inflammatory bowel disease: the EXTRA prospective study from the GETAID
Authors: Guillo Lucas , Savoye Guillaume , Amiot Aurélien , Gilletta Cyrielle , Nachury Maria , Dib Nina , Bourreille Arnaud , Roblin Xavier , Caillo Ludovic , Allez Matthieu , Picon Laurence , Hébuterne Xavier , Seksik Philippe , Chupin Antoine , Buisson Anthony , Brixi Hédia , Altwegg Romain , Simon Marion , Amil Morgane , Laharie David , Bouguen Guillaume , Serrero Mélanie , Elgharabawy Yasmine , Peyrin-Biroulet Laurent
Published: July 2023

Background and aims:

Extraintestinal manifestations (EIM) of inflammatory bowel disease (IBD) are challenging clinical situation. No prospective study assessed remission risk factors for EIMs. Study aimed to prospectively investigate the epidemiology, risk factors for EIM occurrence and EIM remission in a large IBD cohort.

Methods:

We conducted a cross-sectional study in 30 French referral centers. Between May to June 2021, all consecutive patients attending to hospital appointment were systematically invited to fill out a questionnaire.

Results:

A total of 1971 consecutive patients with IBD were analyzed. There were 1056 women (53.8%), and the median age of patients was 41 years [31; 54]. The median disease duration was 11 years [1; 18]. Overall, 544 (27.6%) had at least one EIM. In 20.2% of case, patient had multiple EIMs. The most frequent EIMs were rheumatological (19%) and dermatological (10%) manifestations. Immunosuppressant treatment (OR=2.56; p<0.001) was a risk factor for EIM, while the Montreal A3 classification (OR=0.61, p=0.023) and male gender (OR=0.61, p<0.001) were associated with a lower risk for EIM occurrence. IBD current clinical remission (OR=2.42; p<0.001) and smoking cessation (OR=2.98; p<0.001) were associated factors for EIM remission. Conversely, age at IBD diagnosis (OR=0.98; p<0.018) was associated with a lower risk of EIM remission.

Conclusion:

One quarter of patients had at least one EIM. Beyond factors associated with the presence of EIMs, patients with IBD current clinical remission and smoking cessation are more likely to achieve EIM remission, while increasing age at IBD diagnosis is associated with decreased chance of remission.
The Effect of Postponement Strategy Towards the Financial Performance of Manufacturing Companies in Malaysia
Authors: Ramasamy Sethuraman , Husin Nor Azilah
Published: July 2023

Today’s manufacturing companies must simultaneously deal with externally increasing customers multi-item requirements with rapid lead-time, demanded high-quality products, but internally on a limited capacity. This study aims is to explore the important elements in postponement strategies and to identify the impact of postponement strategies towards financial performance of the manufacturing companies  in Malaysia. Using qualitative research method, this study employs standardized open-ended interviews with five key informants from electronic manufacturing services, solar panel, telco, medical, and latex industries. ATLAS.TI was used to analysed the data. This study reveals that postponement strategies implemented have saved various costs, enhance its product quality, increase production speed, and definitely enhance their profits which results from increase revenue. Overall, this study supports the Service Level Model which suggest that by integrating demand management processes in the postponement strategies, the service level offered to customers can be achieved and it leads to the improvement on the yearly financial performance. The empirical evidence of this study provides a solid foundation for the manufacturing companies in Malaysia to incorporate postponement strategies while observing the market strategy to grab more customers for business enhancement.
Formation of Strategy and Organizational Learning in a Complex Organization: A Case Study at the Military Fire Brigade of Espírito Santo in Brazil
Authors: Júnior Roberto Rodrigues Souza , Cerqueira Alexandre Santos , Gasparini Adriana Schinaider Rigoni , Dumer Miguel Carlos Ramos , Mendonça Mark Miranda , Oliveira Lorrara Silvya Imagawa
Published: July 2023

This study aims to investigate how the implications of learning, in an environment of high unpredictability, impact on the formation of the strategy of the Military Fire Brigade of Espírito Santo. For this, it analyzed the transition of the Strategic Planning (SP) cycle from 2011-2014 to 2015-2019, delimiting this analysis in senior management. As a theoretical foundation, the concepts of strategy formation, emerging strategies and elements of complexity are addressed, especially the role of learning in strategic management. This is a qualitative study, which adopted the single case study method. In data collection, document analysis and semi-structured interviews were carried out. In the data analysis, through the technique of qualitative data analysis, categories of results were established. Through the results, it was evidenced that strategies not carried out in a SP, were formed as emerging strategies in another, including preponderant characteristics of the elements of complexity; it was found that the 2015-2019 strategic planning was formulated with less prescriptive objectives than the previous one, which allowed for greater flexibility in implementation. Finally, in the relationship: learning, dynamism of environmental changes and strategy formation, the cyclical nature of this process was verified.
Dziecko w doświadczeniu maternalnym. O wierszach Joanny Mueller
Authors: Morzyńska-Wrzosek Beata
Published: July 2023

W neolingwistycznej poezji Joanny Mueller istotnym zagadnieniem jest indywidualny wymiar macierzyństwa. Jego liryczne konkretyzacje odznaczają się pogłębioną autorefleksyjnością, poszukiwaniem własnej poetyki, wskazywaniem na przemiany ponowoczesnej estetyki. Poetka, eksplorując możliwości języka, próbując wypowiedzieć doświadczenie maternalne, skupia się nie tylko na tożsamości matki, ale też na podmiotowości dziecka w okresie prenatalnym i niemowlęcym. Charakteryzując jego status, otwierając się na eksperymentowanie z dźwiękową i semantyczną zasobnością języka, w matczynym doświadczeniu wskazuje na radość, troskę, ale też niepewność i lęk. Odsłania potencjalność nowego bytu, znikomość jego istnienia, która wymaga skupienia i przyzwolenia, subtelnych gestów, by załagodzić napięcia towarzyszące wzrastaniu. Mueller, przedstawiając budowanie relacji z dzieckiem, podkreśla współzależność, doznawanie jego bezcenności, odrębności, stopniowe oswajanie się z tym, co nieznane, ukryte, a niezwykle bliskie.
Stan przejściowy: o konstrukcie dzieciństwa w powieściach Anny Cieplak na tle polskiej i anglojęzycznej literatury dla nastolatków
Authors: Kocznur Agnieszka
Published: July 2023

Książki Anny Cieplak, począwszy od Ma być czysto (2016), aż do najnowszej Rozpływam się (2021), poświęcone są przechodzeniu z dzieciństwa do adolescencji, jak i liminalności tych dwóch stanów. W swoich powieściach Cieplak stawia pytania: w którym momencie kończy się dzieciństwo? Czy istnieje jeden wyraźny moment, wydarzenie w życiu młodego człowieka, które dzieciństwo przerywa? Czym może powinniśmy mówić o harmonijnym, rozmytym przechodzeniu między stanami? Portret dzieciństwa, który wydobywa się z powieści Cieplak zostaje skonfrontowany z fantazmatami dzieciństwa zawartymi w innych współczesnych książkach YA – polskich: Agnieszki Wolny-Hamkało i Natalii Osińskiej i zagranicznych: Petry Dvorakowej i Fiony Scarlett
„Dzieciątko, ostrym skrwawione krzemieniem”. O obrzezaniu Jezusa w poezji barokowej
Authors: Szczukowski Ireneusz
Published: July 2023

Celem niniejszego artykułu jest omówienie barokowych tekstów, które dotyczą wyeksponowanego w ewangelii wątku obrzezania. W kulturze religijnej dzieciństwo Jezusa „wytwarzało” znaki odwołujące się do warstwy alegorycznej i symbolicznej. To przede wszystkim żydowski rytuał obrzezania zostaje przywołany przez siedemnastowiecznych twórców. Okazuje się, że odgrywa on ważną rolę w poetyckich rozważaniach, które odwołują się do motywów związanych z okresem świat Bożego Narodzenia, wchodzą w dialog z tradycją religijną (czy teologiczną), próbującą uchwycić znaczenia przypisywane obrzezaniu Jezusa.
Asymptotic modelling of viscoelastic von Kármán membrane shells
Authors: Legougui Marwa , Ghezal Abderrezak
Published: July 2023

The objective of this work is to study the asymptotic justification of the two-dimensional model of viscoelastic von Kármán membrane shells. More precisely, we consider a three-dimensional model for a nonlinearly viscoelastic membrane shell with a specific class of boundary conditions of von Kármán type. Using techniques from formal asymptotic analysis with the thickness of the shell as a small parameter, we show that the
scaled three-dimensional solution still leads to the two-dimensional model of viscoelastic von Kármán membrane shells.
Hölder stability estimates in determining the time-dependent coefficients of the heat equation from the Cauchy data set
Authors: Rassas Imen
Published: July 2023

In this paper, we address stability results in determining the time-dependent scalar and vector potentials appearing in the convection-diffusion equation from the knowledge of the Cauchy data set. We prove Hölder-type stability estimates. The key tool used in this work is the geometric optics solution.
Deciding Together as Faculty: Narratives of Unanticipated Consequences in Gendered and Racialized Departmental Service, Promotion, and Voting
Authors: Smith-Doerr Laurel , Mickey Ethel L. , Kane-Lee Ember Skye W.
Published: July 2023

Workplace inequalities scholarship often assumes making people aware of problems will lead to change, although gendered and racialized organizations theories show systemic problems beyond individual awareness. Still, not enough research analyzes the narratives of savvy organizational actors – like university faculty aware of inequalities – to understand the mechanisms operating against leveraging that knowledge for change. Data consist of 10 group interviews with 45 faculty across departments in one US public university, supplemented by content analysis of 56 departments’ written bylaws. Findings focus on three common shared decisions: committee service, hiring/promotion, and voting practices.We find awareness of inequality may actually reinforce the status quo when narratives about gendered and racialized processes feature decoupling from formal bylaws, and when narratives about outcomes relate to multiple layers of unanticipated consequences favoring whiteness and men.Specifically, inequality is reproduced when narratives about gendered and racialized unanticipated consequences: 1) highlight the imperviousness of change, as in the difficulty of allocating service work equitably, 2) lack reflexivity and shift responsibility to ‘other’ groups – ‘faculty’ or ‘administrators’ – as in unequal hiring and promotion decisions, and 3) focus on standard old boy stories which obscure other inequalities, as in faculty voting where non-tenure track rank inequality obscures race/gender inequalities. When unanticipated consequences narratives have dimensions of fatalism, finger pointing, and blindness to intersectionality, white men may continue to benefit. This study shows how formal policies and awareness of inequalities may still fail to produce change.
Hsa_circ_0028007 regulates the progression of nasopharyngeal carcinoma through the miR-1179/SQLE axis
Authors: Li Wenya , Jiang Xiuwen , Zhao Lina
Published: July 2023

Nasopharyngeal carcinoma (NPC) is one of the most ordinary malignant tumors. Current research has suggested that circular RNAs play an important role in tumor genesis and progression. The purpose of this study is to explore the function and underlying mechanisms of circ_0028007 in NPC. The levels of circ_0028007, miR-1179, and Squalene epoxidase (SQLE) were detected by quantitative real-time polymerase chain reaction. Cell proliferation was detected by colony formation assay and thymidine analog 5-ethynyl-2′-deoxyuridine assay. Cell apoptosis was detected by flow cytometry. Relevant kits detected caspase-3, glucose, and lactate levels. Western blot assay was used to detect the related protein content. Dual-luciferase reporter assay and RNA pull-down assay were used to examine the target relationship between miR-1179 and circ_0028007 or SQLE. circ_0028007 and SQLE were highly expressed in NPC, while miR-1179 was lowly expressed. circ_0028007 silencing inhibited NPC cell proliferation and promoted apoptosis. However, the effect of circ_0028007 down-regulation on NPC cells was partially restored by co-transfection with miR-1179 inhibitor. Overexpression of SQLE partially restored the cell proliferation inhibited by circ_0028007 knockdown. circ_0028007 could regulate NPC progression via the miR-1179/SQLE axis. Therefore, circ_0028007 might be a new therapeutic target for NPC.