bluuebunny/crossref_metadata_2025 huggingface dataset:
Analyse der Expression verschiedener Spleißformen des MUTYH-Gens bei darmgesunden Probanden im Vergleich zu Polyposis-Patienten
Authors:   , Heckel Verena
Published: October 2024

Bedingt durch eine Vielzahl schädigender exogener sowie endogener Faktoren kommt es zu chemischen Veränderungen der DNA. Modifizierte Nukleotide, allen voran 8-oxo-Guanin, sind unmittelbar an Alterungsprozessen beteiligt und stehen am Anfang der Karzinogenese. Normalerweise werden solche DNA-Schäden von zelleigenen Reparaturmechanismen behoben. Kommt es durch Mutation von Reparaturenzymen zu einem Verlust dieser Funktion, ist eine Anhäufung von Mutationen der DNA die Folge. Diese werden mit jeder Replikation bei der Zellteilung weitergegeben. Diese Arbeit beschäftigt sich mit dem Krankheitsbild der MUTYH-assoziierten Polposis coli (MAP), welche durch den genetischen Ausfall des DNA-Reparaturenzyms MUTYH verursacht wird. Dieses Reparaturenzym ist Bestandteil der sogenannten Basen-Excisionreparatur (BER). Phänotypisch kommt es bei Betroffenen zur Ausbildung von zehn bis hundert Adenomen am Kolon und Rektum. Da Adenome als Präkanzerosen gelten und daraus sehr wahrscheinlich ein Kolorektales Karzinom (CRC) entsteht, ist das Darmkrebsrisiko bei Polyposispatienten auf Grund der hohen Polypenanzahl um ein Vielfaches erhöht. Bei MAP sind bisher etwa 60 Mutationen im MUTYH-Gen beschrieben. Besondere Bedeutung kommt den Veränderungen Y179C und G396D zu, welche am häufigsten gefunden wurden. In dieser Arbeit wurde die Expression des MUTYH-Gens anhand von drei Polyposis-Patienten und gesunden Vergleichspersonen analysiert. Bei diesen Patienten wurde die bekannte pathologische Veränderung Gly396Asp (G396D) gefunden, aber auch eine nicht charakterisierte Veränderung in der Spleißstelle des Exons 1β von MUTYH sowie eine unklare, verbreitete Missense-Veränderung (Q324H). Die Relevanz der Splicesitemutationen bei der Entstehung der MAP wurde untersucht, indem bei darmgesunden Probanden eine Splicinganalyse bezüglich der Häufigkeitsverteilung von Spleißvarianten im MUTYH-Gen durchgeführt wurde. Zusätzlich wurde die Expression dieser Spleißvarianten auf Proteinebene beurteilt. Im letzten Schritt wurde die Proteinexpression der Spleißvariante α3-Wildtyp (WT) bei gesunden Probanden mit Variante α3-Q324H bei MAP-Patienten verglichen. Die Ergebnisse zeigten, dass von allen drei Exon1-Spleißvarianten α, β und γ die Spleißvariante 3 von Exon 3 mit fast 60% am häufigsten vorkommt. 42% der untersuchten Klone weisen Exondeletionen auf. Betroffen waren meist die Exons 3-6, 7 und 8. Hinsichtlich der Proteinexpression besteht eine gleich starke Expression der Varianten α1-5 sowie β/γ 1-5. Der Vergleich der Proteinexpression von α3-WT mit α3-Q324H zeigte, dass die veränderten Proteine offensichtlich weniger stark exprimiert sind. Durch die gewonnenen Erkenntnisse konnte erstmalig ein vollständiges Bild der Expression der relevanten mRNA- und Proteinisoformen des stark alternativ gespleißten MUTYH-Gens gewonnen werden. Abschließend wurden die gewonnenen Erkenntnisse im Kontext der Patienten-Mutationen verglichen.
Políticas educativas interculturales en México de 1980 a 2022
Authors: Castro Porcayo David
Published: October 2024

El artículo tiene el propósito de explorar cómo se ha abordado la dimensión de la interculturalidad en las políticas educativas, en un periodo que abarca de los años anteriores a 1980 a 2022. El propósito fue  entender cómo discursivamente se han objetivado políticas educativas en relación con la interculturalidad. La investigación tiene un enfoque cualitativo, un método bibliográfico y de análisis de discurso. Se identificaron tesis que han funcionado como “puntos de capitón”, término empleado por Lacan (2009) para explicar cómo el lenguaje, que está en constante desplazamiento, necesita estos puntos para estabilizar momentáneamente el sentido del discurso. Se ubicaron tres periodos aproximados que abarcan de antes de 1980, de 1982 a 2018 y 2018 a 2022, y se caracterizan por sus circunstancias históricas que determinaron los fines de la educación intercultural.
Application of SWAT to assess peatland forestry impacts on water quality
Authors: Bhattacharjee Joy , Marttila Hannu , Molina Navarro Eugenio , Kløve Bjørn
Published: October 2024

Peatland drainage can affect the natural state of hydrological conditions and nutrient loading but is rarely included in catchment-scale models. To understand the gap, we aimed to use the soil and water assessment tool (SWAT) to observe drained peatlands and their properties to predict nutrients and suspended solids (SS) in the peatland-dominated Simojoki catchment. We integrated drainage networks in SWAT to (i) identify drainage parameters; (ii) determine annual loads and mean concentrations of SS, organic phosphorus (Org-P), total phosphorus (TP), organic nitrogen (Org-N), and total nitrogen (TN); (iii) understand spatial variation of nutrients and SS; and (iv) investigate uncertainty ranges for the estimates. The calibrated model showed a 9.6 per cent bias between the simulated flow and the observations with low-to-medium loading variations for the water quality parameters. For Org-N and TN, the highest loading per year was at the downstream outlet, whereas for SS, Org-P, and TP, it was higher at the upstream outlet of the catchment. This approach of representing the drained peatland in SWAT indicated maximum spatial distributed load in the peat soil in the clear-cut area and can be beneficial in future hydrological modelling efforts in identifying the status of nutrients or SS.
Urban Water System of the National Capital Territory (NCT) of Delhi: A Comprehensive Study
Authors: Parveen Adeeba , Ahmad Syed Naushad
Published: October 2024

This study examines the intricate relationship between Delhi's urban water system and environmental factors, with a specific emphasis on the challenges posed by urbanization. It investigates the present conditions of the water resources, infrastructure, and governance in the National Capital Territory (NCT) of Delhi and identifies significant difficulties, such as depletion of groundwater and inadequate access to water. Additionally, it explores innovative approaches to strengthen supply internalization, such as rainfall harvesting, wastewater recycling, and demand management strategies. Therefore, this document establishes a path for future research endeavors and policy suggestions that aim to promote a fair, effective, and environmentally sustainable future for water in Delhi.
Solar-enhanced DCMD: Dual-tank system for superior efficiency and viability
Authors: Alsehli Mishal
Published: October 2024

This study investigates a novel solar-powered direct contact membrane distillation (DCMD) system designed to significantly enhance desalination efficiency and economic feasibility. The system features a dual-tank configuration integrated with a solar collector, which optimizes thermal energy storage and ensures consistent feedwater temperatures. Therefore, continuous operation is possible despite fluctuations in solar radiation. An assessment of the system's performance under various solar radiation conditions predicted an average daily permeate flux of 14.4 kg/m2 and a specific energy consumption of 1810 kJ/kg, indicating superior thermal efficiency. The economic analysis revealed a competitive levelized water cost of $25.75 per cubic meter, highlighting the system's potential as a viable alternative to conventional desalination technologies. These findings suggest that the proposed DCMD system is a leading technology in the pursuit of sustainable desalination. Considering its thermal management and cost-effectiveness, the system presents a transformative solution for sustainable freshwater production in regions with abundant solar resources.
Navigating the definition of urban flooding: A conceptual and systematic review of the literature
Authors: Alves Priscila B. R. , Amanguah Ebenezer , McNally Devin , Espinoza Maria , Ghaedi Hamed , Reilly Allison C. , Hendricks Marccus D.
Published: October 2024

Urban flooding is a pervasive global risk, posing a great challenge to urban planners, policymakers, and particularly communities. This paper reviews the literature to analyze how urban flooding is defined across scientific disciplines. Our objectives are to uncover the elements used to define urban flooding and evaluate how these elements can impact future research and practice. A key difficulty is the lack of a consistent, comprehensive definition that captures both physical and social dimensions of urban flooding. Current definitions often focus solely on physical aspects (e.g., rainfall, infrastructure) or social impacts, rarely integrating both. This fragmentation hinders effective flood risk management and interdisciplinary collaboration. Our contribution is a multifaceted definition incorporating spatial and social concerns, including water origins, built environment characteristics, and local community aspects. We introduce the ‘Urban Water Transect’ concept to illustrate the continuum of flood risk across urban zones, addressing a gap in the literature. The analysis reveals that many papers discuss flooding causes without providing an explicit definition. Urban flooding is predominantly defined based on water source, imperviousness, and drainage infrastructure. Future research should adopt an interdisciplinary perspective considering both physical and social aspects, potentially transforming urban flood risk management.
TÜRKİYE VE BAZI AVRUPA ÜLKELERINDEKİ ORTAOKUL GÖRSEL SANATLAR DERSİ ÖĞRETİM PROGRAMLARININ KARŞILAŞTIRILMASI
Authors: Tuna Serdar , Çakır İlhan Ayşe
Published: October 2024

Bu araştırmanın amacı; Türkiye, Almanya, Fransa ve İngiltere’de ortaokul Görsel Sanatlar dersi öğretim programlarını amaç, içerik, eğitim durumları, ölçme ve değerlendirme süreçleri açısından incelemek, farklılık ve benzerlikleri saptamak ve bu konuda ayrıntılı veri kaynağı oluşturmaktır. Bu araştırmada, ülkelerarası karşılaştırmalı eğitim araştırması modeli kullanılmıştır. Söz konusu ülkelerin görsel sanatlar dersi öğretim programlarının karşılaştırılmasında “yatay yaklaşım" kullanılmıştır. Araştırma sonucunda, araştırmaya konu olan ülkelerin öğretim programlarının amaç, içerik, eğitim durumları, ölçme ve değerlendirme süreçleri bakımından benzer özelliklere sahip oldukları, fakat birtakım farklılıklar da içerdikleri belirlenmiştir. Sonuç olarak programlarda; Sanatsal Beceri ve Bireysel İfade, Sanat Eleştirisi, Kültürel Miras ve Çeşitlilik ile ilgili amaçların, Sanatsal Biçimlendirme, Sanatsal Yöntem ve Teknikler ile ilgili içeriklerin, kullanılan geleneksel yöntemlerle ilgili eğitim durumlarının ve süreç dosyası değerlendirme gibi değerlendirme araçlarının benzer oldukları saptanmıştır. Buna karşın, Çevresel Farkındalık, Estetik, Özgüven ve Saygı gibi maddelerin amaçlarda; Dijital Teknoloji ve Sergileme gibi maddelerin içerikte, Bireysel Deneyimler, Bağımsız Öğrenme Becerileri, Takım Çalışması gibi maddelerin eğitim durumlarında, her sınıf seviyesi için ölçek oluşturma, değerlendirmede inisiyatif kullanma gibi maddelerin, ölçme ve değerlendirme yaklaşımlarında farklılaştığı saptanmıştır.
KAYNAŞTIRMAYA İLİŞKİN SUNULAN YETERLİK EĞİTİMİNE YÖNELİK ÖĞRETMEN ADAYLARININ GÖRÜŞLERİ: İYİ BİR KAYNAŞTIRMA İYİ BİR UYGULAYICI İSTER PROJESİ
Authors: Ketenoğlu Kayabaşı Zehra Esra , Kurt Ali , Akar Eylül , Kurtuluş Uzlu Melike , Ünsal Alparslan , Özdemir Melike
Published: October 2024

Bu araştırmada, Türkiye Bilimsel ve Teknolojik Araştırma Kurumu (TÜBİTAK) destekli bir proje kapsamında öğretmen adaylarına verilen kaynaştırmaya ilişkin yeterlik eğitimine yönelik projeye katılan öğretmen adaylarının görüşlerinin incelenmesi amaçlanmıştır. Araştırmada nitel araştırma yöntemlerinden fenomenoloji deseni kullanılmıştır. Araştırmanın katılımcı grubunu projeye katılım sağlayan 14 öğretmen adayı oluşturmaktadır. Araştırmanın verileri yarı yapılandırılmış görüşme formuyla toplanmış ve içerik analizi yoluyla analiz edilmiştir. İçerik analizi sonucunda kaynaştırma yeterlik eğitimi ana teması altında eğitimin katkıları, eğitimde yaşanan aksaklıklar, eğitim sonrası sahada yapılması planlananlar ve gelecekteki eğitimlere yönelik beklentiler olmak üzere dört alt temaya ulaşılmıştır. Araştırma sonucunda öğretmen adayları sunulan eğitim hakkında çoğunlukla olumlu görüş bildirerek kaynaştırmaya yönelik bakış açılarında olumlu yönde bir değişim meydana geldiğini belirtmiştir. Ayrıca öğretmen adayları özel gereksinimi olan bireylere yönelik farkındalıklarının ve onlarla çalışmaya ilişkin özgüvenlerinin arttığını, bilgi edindiklerini, ileride öğretmen olduklarında bireysel farklılıkları göz önünde bulundurarak çeşitli düzenlemeler yapabileceklerini, materyal hazırlayabileceklerini ve sınıf ortamını uyarlayabileceklerini belirtmişlerdir. Araştırmadan elde edilen bulgular ilgili literatür ışığında tartışılarak ileri araştırmalara yönelik önerilerde bulunulmuştur.
AKADEMİSYENLERİN KİBİR YÖNELİMİ ÖLÇEĞİ (AKYÖ): GEÇERLİK VE GÜVENİRLİK ÇALIŞMASI
Authors: Demirbilek Mesut , Akpolat Tuba , Keser Sıtar
Published: October 2024

Bu çalışmanın amacı akademisyenlerin kibir yönelimlerini ölçmeye yarayan geçerli ve güvenilir bir ölçeğin geliştirilmesidir. Bu amacı gerçekleştirmek için ölçek geliştirme aşamaları takip edilerek; öncelikle alan yazından destek alınarak madde havuzu oluşturulmuştur. Ardından taslak form, uzman görüşüne sunularak kapsam geçerliliği ve anlaşılırlık kapsamında iyileştirmeler yapılmıştır. Araştırmanın örneklemini 2023 yılında İstanbul ilinde bulunan lisans-lisansüstü öğrencileriyle, aynı yıl mezun olmuş olan lisans-lisansüstü toplam 314 öğrenci oluşturmaktadır. Ölçeğin yapısının doğrulanması için ise 245 lisans-lisansüstü öğrenci ve mezun örneklem olarak seçilmiştir. Ölçeğin yapı geçerliği için açımlayıcı faktör analizi yapılmış ve Akademisyenlerin Kibir Yönelimi Ölçeği’nin üç faktörden oluşan bir yapı sergilediği görülmüştür. Söz konusu üç faktör toplam varyansın %69’unu açıklamaktadır. Ölçeğin tamamı için iç tutarlılık katsayısı .96’dır. Ortaya konan yapının doğrulanması için doğrulayıcı faktör analizi yapılmış ve yirmi iki madde, üç boyuttan oluşan akademisyenlerin kibir yönelimi ölçeğinin yapısının doğrulandığı görülmüştür. Sonuç olarak, Akademisyenlerin Kibir Yönelimi Ölçeği’nin; itibarsızlaştırma, üstenci yaklaşım ve kıyaslama boyutları ile akademisyenlerin kibir yönelimlerini ortaya koyacak güvenilir ve geçerli bir ölçme aracı olduğu ortaya konmuştur.
Buenas prácticas para el establecimiento y desarrollo de un modelo de producción de marañón bajo en carbono en la región de la altillanura colombiana
Authors: Parrado Moreno Carmen Alicia , Mateus Cagua Diana Mayerly , Correa Pinilla Diana Elisa , Peña Quiñones Andrés Javier , Bernal Riobo Jaime Humberto , Pulido Castro Sandra Xiomara , Arango Wiesner Laura Victoria
Published: October 2024

El sector agrícola y el cambio de uso del suelo aportan cerca de la cuarta parte de las emisiones globales de gases efecto invernadero (GEI). Las emisiones asociadas a la agricultura están relacionadas principalmente con sus prácticas de manejo. De acuerdo con esto, la agricultura tiene también el potencial de ser sumidero de GEI mediante la implementación de estrategias de innovación y uso de tecnologías eficientes para avanzar en programas de mitigación, adaptación y conservación de los recursos. Esta publicación tiene como propósito presentar un conjunto de mejores prácticas que conduzcan a consolidar agroecosistemas de marañón bajos en carbono, así como las ventajas de implementarlas, considerando el potencial que tiene este sistema para la fijación y el almacenamiento de carbono. De esta forma, los actores de la cadena de marañón tendrán mayores herramientas para la toma de decisiones informadas, a la vez que contribuyen a la reducción y mitigación de GEI en el país.
Antibiotic Prescribing Behavior of Physicians in Outpatient Departments in Hospitals in Northwest Ethiopia: Structural Equation Modeling Approach (Preprint)
Authors: Abejew Asrat Agalu , Wubetu Gizachew Yismaw , Fenta Teferi Gedif
Published: October 2024

BACKGROUND

Antibiotic resistance, fueled by irrational prescribing, is a global threat associated with health, social, and economic consequences. Understanding antibiotic prescribing behavior and associated factors is important to promote good prescribing practice.

OBJECTIVE

This study aimed to determine the factors affecting antibiotic prescribing behaviors of physicians based on the theory of planned behavior in hospitals in northwest Ethiopia in 2022.

METHODS

A cross-sectional study was conducted from September 2022 to October 2022. A total of 185 health professionals were included, and a self-administered questionnaire was used to collect data. A structural equation model based on the modified theory of planned behavior was used to determine factors affecting antibiotic prescribing behavior. The percentages of physicians’ estimated prescriptions for patients with upper respiratory tract infections (URTIs) and during weekly outpatient visits were used to predict antibiotic prescribing behavior and finally linked with behavioral constructs. A P value <.05 was considered significant.

RESULTS

Physicians estimated that they prescribed antibiotics for 54.8% (9896/18,049) of weekly outpatient encounters, and 178 (96.2%) of the 185 physicians estimated they prescribed antibiotics for patients who presented with symptoms of a URTI. Physicians aged ≤30 years were less likely to prescribe antibiotics (48/100, 48%) for patients who presented with a URTI than physicians older than 30 years (51/100, 51%; P=.004), and general practitioners were less likely to prescribe antibiotics (47/100, 47%) for patients who presented with a URTI than residents (51/100, 51%; P=.03). Similarly, during outpatient visits, physicians ≤30 years old were less likely to prescribe antibiotics (54/100, 54%) than physicians older than 30 years (57/100, 57%; P<.001), male physicians were less likely to prescribe antibiotics (53/100, 53%) than female physicians (64/100, 64%; P=.03), and general practitioners were less likely to prescribe antibiotics (53/100, 53%) than residents (57/100, 57%; P=.02). Physicians with good knowledge were less affected by perceived social pressure (mean 4.4, SD 0.6) than those with poor knowledge (mean 4.0, SD 0.9; P<.001) and felt it was easy to make rational decisions (mean 4.1, SD 1.1) compared with those with poor knowledge (mean 3.8, SD 1; P<.001). However, intentions to reduce and prescribe antibiotics were not affected by attitudes, subjective norms, or perceived behavioral control, and perceived antibiotic prescribing behavior was not related to intentions to reduce or prescribe antibiotics.

CONCLUSIONS

Antibiotic prescribing behavior was not under the volitional control of physicians. This calls for a systematic approach to change antibiotic prescribing practices in hospital.
Determinants of Healthcare Technology Adoption: A Systematic Review and Meta-Analysis Using the Unified Theory of Acceptance and Use of Technology (UTAUT) (Preprint)
Authors: Thanthrige Ayesha , Wickramasinghe Nilmini , Lu Bruce , Sako Zaid
Published: October 2024

BACKGROUND

Healthcare technology adoption is key for improving patient care, enhancing operational efficiency and better health outcomes. Examining the determinants that influence the acceptance and use of healthcare technologies is crucial for developers, healthcare providers and policymakers. The Unified Theory of Acceptance and Use of Technology (UTAUT) offers a comprehensive framework to assess these determinants systematically.

OBJECTIVE

This systematic review and meta-analysis aim to identify and analyse the key factors influencing the adoption of healthcare technologies based on UTAUT framework. By synthesizing existing literature, the study seeks to provide valuable insights for stakeholders to implement effective and innovative solutions in healthcare domain.

METHODS

A search was conducted across databases including Medline and Embase, IEEE Xplore Science Direct, Scopus, CINAHL, Google Scholar, and Web of Science. Inclusion criteria covered studies applying the UTAUT model to healthcare technology adoption, published in English between 2014 and 2024. Exclusion criteria included non-quantitative studies, studies not focused on healthcare settings, and those lacking sufficient data for meta-analysis. Data were analysed using meta-analytic techniques to combine findings and calculate effect sizes for UTAUT constructs.

RESULTS

A total of 35 studies with 20,723 participants met the inclusion criteria, representing various healthcare technologies such as Electronic Health Records (EHRs), telemedicine platforms, and mobile health applications. The meta-analysis revealed that Performance Expectancy (PE) emerged as the most significant predictor of Usage Intention (UI) (β=.304; P<.01), while UI was the primary predictor of Usage Behavior (UB) (β=.199; P<.01). The study synthesized data from a total of 35 studies and other significant predictors included Effort Expectancy (EE) (β=.177; P<.01), Social Influence (SI) (β=.167; P<.01) and Facilitating Conditions (FC) (β=.105; P<.01). Variability was observed across different healthcare settings and geographical regions, indicating that contextual factors play a crucial role. Limitations include potential publication bias among included studies.

CONCLUSIONS

This study delivers valuable insights for researchers, developers and healthcare providers aiming to enhance technology adoption within the healthcare industry. The findings highlight the importance of performance expectancy, effort expectancy, social influence, and facilitating conditions in driving healthcare technology adoption. These results can guide future interventions to improve the adoption of health technologies, finally enhancing patient care and efficiency.

CLINICALTRIAL

N/A
A personalized and smartphone-based, serious gaming application targeting cognitive impairments in alcohol use disorder: A piloting, double-blinded, randomized controlled trial (Preprint)
Authors: Mistarz Nicolaj , Andersen Kjeld , Goudriaan Anneke , Skøt Lotte , Sheldrick-Michel Tanja , Mellentin Angelina Isabella
Published: October 2024

BACKGROUND

Alcohol use disorder (AUD) is associated with cognitive impairments that are known to increase the risk of relapse and impede on the outcomes of conventional treatment. Digital cognitive training programs have been examined as a possible way of addressing these overlooked challenges. However, existing findings regarding the effectiveness of such training programs are divergent, and further studies are warranted to examine more engaging cognitive training programs using the latest technology. Furthermore, the clinical implementation of the training programs must be investigated to ensure the best and most effective treatment for patients with AUD. Using smartphone-based training built upon the principles of serious gaming would not only increase the accessibility of the program but it could also increase the motivation and compliance of the patients – potentially maximizing adherence to the training program.

OBJECTIVE

The aim of the present pilot and feasibility study was to examine whether a smartphone application with gamified elements can improve cognitive and alcohol-related outcomes among patients with AUD when delivered as add-on to treatment-as-usual (TAU) and with minimal guidance from health-care practitioners. An adapted version of the Brain+ application was tested, and the feasibility and acceptability were assessed.

METHODS

A total of 72 outpatients were randomized into either: Group A) experimental + TAU (n = 36), or Group B) sham + TAU (n = 36), and they had to complete a 1-month training program in addition to primary treatment. Cognitive functions and alcohol consumption were assessed at baseline, post-treatment, and at six months follow-up.

RESULTS

The experimental group demonstrated significant improvements in processing speed and attention (P = .019) as well as working memory (P < .001). Although no significant differences were found between the two groups regarding clinical outcomes, a pattern favoring the experimental group was evident regarding the mean change reduction in alcohol consumption between the assessment at baseline and 6-months follow-up. The Brain+ application was feasible and accepted by both groups, and the experimental group adhered to the minimum training requirements.

CONCLUSIONS

The smartphone-based, serious gaming application showed promising effects for improving cognitive functions when delivered as add-on to TAU, but a larger scaled trial should be conducted in the future to assess its potential clinical effectiveness.

CLINICALTRIAL

A pre-registered and published research protocol is available (IRRID: RR2-10.3389/fpsyt.2021.727001)

INTERNATIONAL REGISTERED REPORT

RR2-10.3389/fpsyt.2021.727001
Effectiveness of the UK AML System and Strategies for Improvement
Authors: Liu Chenyang
Published: October 2024

As the cost of anti-money laundering (AML) compliance in the UK continues to rise, financial crime rates have not fallen. This study assesses the effectiveness of the UK’s anti-money laundering (AML) system and proposes strategies for improvement. The research examines the current legal framework, including the Proceeds of Crime Act (POCA) and the Money Laundering Regulations 2017 (MLR2017), assessing their role in preventing and combating financial crime. Analyzing case studies and statistical data, the findings suggest that while the UK AML system has been effective in identifying and deterring money laundering, significant challenges remain. Insufficient sharing of information between agencies, uneven allocation of resources, and inconsistent regulatory enforcement hinder overall effectiveness. To address these shortcomings, the study makes several strategic recommendations: strengthening inter-agency cooperation, leveraging advanced technological solutions for data analysis and reporting, improving training and awareness programmes for financial institutions, and improving the legal framework to adapt to emerging threats. Implementing these recommendations could strengthen the UK’s anti-money laundering (AML) efforts, making them more robust and responsive to the evolving financial crime landscape. Ultimately, this study aims to contribute to the current debate on the effectiveness of AML and to make recommendations for improving the AML system’s response to the complexities of money laundering in order to strengthen the UK’s position in the global fight against money laundering.
Revolutionizing Education through AI: Alleviating Educator Stress, Personalizing Learning, and Enhancing Economic Sustainability
Authors: Li Yingyang , Liang Jinming , Zhao Zirui , Li Kexin
Published: October 2024

The current education industry faces critical challenges, including overwhelming educator workloads, a lack of personalized student learning, and unsustainable financial models. This paper explores how artificial intelligence (AI) can offer solutions to these systemic issues, focusing on three key areas: reducing teacher burnout, enhancing student engagement through personalized education, and improving the financial sustainability of educational institutions. The study investigates the advantages of adaptive learning systems for customizing educational experiences for each student, the impact of automated tools in easing administrative burdens on teachers, and the optimization of institutional resources to lower operating costs through a thorough analysis of current AI-based projects. These results demonstrate how AI has the potential to revolutionize conventional educational approaches. Still, they also show that to fully realize its promise, more extensive systemic changes are required.
Propuesta de rúbricas para evaluar el examen de candidatura al grado de doctor
Authors: Fortoul Teresa Imelda , Ochoa Cabrera Alba , Muñoz Comonfort Armando
Published: October 2024

Introducción: El examen de candidatura al grado de doctor es de altas consecuencias, por lo que es deseable que se cuente con rúbricas para evaluar tanto la competencia escrita como la oral.
Objetivo: Contar con evidencias de validez de la aplicación de rúbricas para evaluar a los estudiantes que presentan el examen de candidatura al grado de doctor.
Método: Estudio transversal no experimental. Se aplicaron rúbricas modificadas de unas ya existentes que se empleaban para evaluar la parte escrita del examen y otra para la evaluación de la presentación oral. A ambos se les aplicó una escala numérica para determinar si se otorgaba o no la candidatura. Se aplicó a 195 estudiantes de las generaciones 2019, 2020, 2021 y 2022 de todos los campos disciplinarios. Se realizó el análisis de confiabilidad, diferencia de medianas y un análisis de extracción factorial mediante el método de componentes principales.
Resultados: Al menos se obtuvieron tres evidencias de validez de acuerdo con Messick. No hubo diferencias en los resultados numéricos de acuerdo con: la generación, el sexo del estudiante, el número de sinodales o los puntajes en la evaluación escrita o la oral. Los análisis de componentes principales de ambas versiones mostraron un solo componente para la evaluación escrita y dos componentes para la evaluación oral.
Conclusión: Las nuevas rúbricas han funcionado y presentan resultados positivos, ya que la evaluación es más objetiva en comparación con el formato anterior y el hecho de que sea colegiada ha permitido la unificación de la evaluación entre los sinodales. Con estas rúbricas se evalúan las habilidades de comunicación escrita y oral de manera independiente y será de interés hacer un seguimiento de la relevancia que esta separación tendrá en los resultados del examen de candidatura.
Footwear Pattern Making and Grading Calculations Based on International Standard of Measurements
Authors: Obaidullah Hafiz
Published: October 2024

Abstract: Footwear pattern making and grading are fundamental processes in footwear design, critical for creating shoes that are well-fitting, balanced, and aesthetically appealing. Key considerations in pattern making include accurately calculating essential measuring parameters of the last to ensure perfect fit and balance. Additionally, grading is vital for developing different size ranges from the master pattern. This research paper investigates the calculations of essential measuring points of footwear based on foot anatomy and discusses longitudinal and transverse grading factors. By exploring calculations involved in pattern making and grading according to international measurement standards, the paper aims to determine the ideal calculations and grading parameters for various footwear styles. The study examines footwear measuring terminologies and derives standard formulas by analyzing diverse techniques and standards, providing insights into best practices for footwear designers and pattern developers to achieve consistency and quality in their products.
Review Paper on Seismic Analysis of Multi-Storied Reinforced Concrete Building with Fluid Viscous Dampers
Authors: Gupta Harshit , Kumar Dr. Ragvendra
Published: October 2024

Abstract: Frequent earthquakes around the world and the large number of buildings at risk have made it essential to focus on controlling how structures respond to these events. This demand has driven the increased use of structural response control methods globally. This study investigates the seismic performance of multi-storied Reinforced Concrete (RC) Buildings, distinguishing between Regular and Irregular Plan , with a focus on the role of Fluid Viscous Dampers (FVDs). The study aims to quantify the improvements in seismic resilience provided by these damping devices in mitigating the adverse effects of seismic events. Buildings having Regular and Irregular Plans are analyzed, with and without FVD using ETABS2018. The story responses in terms of Pseudo Spectral Accelerations, Maximum Displacement, Story Drift and Story Shear have been compared. The results of the Time History Analysis represent the effectiveness of dampers in improving the structural response and the damping demand on structural systems
Brain Tumor Detection and Classification Using MRI Images
Authors: Mahesh Greeshma , M Yogesh K
Published: October 2024

Abstract: Brain tumors pose a serious health risk, and prompt and precise identification is essential for successful treatment. This article describes an automated method employing convolutional neural networks (CNNs) to identify and categorize brain cancers in MRI images. The dataset that was used consists of 7,023 MRI scans that were obtained from three different sources: the Br35H dataset, the SARTAJ dataset, and the fig share repository. Four classes are identified from the images: pituitary tumors, gliomas, meningioma’s, and no tumor. With the use of this improved dataset, the CNN model was created and trained, ultimately attaining a 97.5% test accuracy. Moreover, class-wise analysis showed that the precision values for pituitary tumors were 96.1%, 98.8%, 96.1%, and 98.6%, respectively, with equivalent recall rates of 94.7%, 95.4%, 100%, and 99% for gliomas, meningioma’s, and no tumors. With values of 0.966 for gliomas, 0.957 for meningioma’s, 0.994 for no tumor, and 0.975 for pituitary tumors, the F1-scores demonstrate the general resilience of the model. These findings show that the suggested CNNbased method is effective in assisting with brain tumor diagnosis from MRI scans, providing radiologists and other medical practitioners with a useful tool. In order to improve diagnostic accuracy, future study may entail enhancing the model even further and investigating the integration of other imaging modalities
Etableringen av en norsk klavertradisjon: Interpretative trekk ved Edvard Griegs Ballade op. 24, Geirr Tveitts Sonate nr. 29 op. 129 og Fartein Valens Sonate nr. 2 op. 38.
Authors: Einar Røttingen
Published: October 2024

The theme of this dissertation is three important Norwegian piano works. The dissertation includes a main text, a recording and a critical/practical edition of Valen’s Sonata no.2 op.38. By using a musicological/analytical and artistic approach, this dissertation aims to create a greater understanding for these three works as a part of a Norwegian and continental European piano tradition. The main text investigates the contents of the music and how the works are built. It looks at the performance indications in the score and performance practice traditions (historical recordings). References and allusions to other works in the same genres and to similar piano styles are discussed. By looking at possible autobiographical and metaphorical allusions, the dissertation aims at finding an understanding for the works’ origin and meaning. The critical and practical edition contributes for the first time to correct errors and unclear readings of the existing edition and presents a possible realization of Valen’s incomplete score. The main text also includes general criteria for the interpretative choices on the CD. (Norwegian version only, some parts are translated to English as articles)
Simulating Complex CO2 Background Conditions for Indianapolis, IN, with a Simple Ecosystem CO2 Flux Model
Authors: Murphy Samantha Lynn , Davis Kenneth J. , Miles Natasha L , Barkley Zachary Robert , Deng Aijun , Horne Jason , Richardson Scott J. , Gourdji Sharon Muzli
Published: October 2024

We evaluated the ability of a simple ecosystem carbon dioxide (CO2) flux
model, the Vegetation Photosynthesis and Respiration Model (VPRM), to
capture complex CO2 background conditions observed in Indianapolis, IN.
Using simulated biogenic CO2 fluxes and mole fraction tower influence
functions, we estimated biogenic CO2 mole fractions at three background
towers in the Indianapolis Flux Experiment (INFLUX) network from April
2017 to March 2020. The model captures afternoon average CO2
enhancements, the difference between the background towers and a common
reference tower, at a monthly time scale with no significant bias, with
monthly mean residuals rarely differing significantly from zero.
Although not central to our application, the model could not capture
day-to-day variations of observed afternoon average CO2 enhancements.
Random errors, when averaged over monthly to yearly time scales, were an
order of magnitude smaller than typical urban enhancements. VPRM
captured site-to-site differences in the average observed daily cycle of
CO2 fluxes at agricultural eddy covariance flux sites well. For 13 of 14
site-months, the modeled peak afternoon NEE was within 30% of that
observed despite the observed peaks ranging from about -7 to -70 µmol
m-2s-1. VPRM can be effectively used in CO2 inversions to represent
complex seasonal variations in background conditions observed in
Indianapolis. Indianapolis, a modest-size city surrounded by strong
ecosystem fluxes, represents a rigorous test for the VPRM system.
Further, this study presents an evaluation system that can be applied to
assess the performance of other ecosystem CO2 flux models in cities with
similar monitoring networks.
Rola władz samorządowych w kreowaniu zrównoważonego rozwoju gmin wiejskich województwa małopolskiego
Authors: Paluch Łukasz
Published: October 2024

Celem opracowania jest próba oceny roli władz samorządowych w kreowaniu zrównoważonego rozwoju gmin wiejskich województwa małopolskiego. Przy wyborze jednostek do badań terenowych wykorzystana została wielokryterialna metoda unitaryzacji zerowanej, a podstawowe źródło informacji stanowiły dane statystyczne za lata 2004-2010 publikowane przez Bank Danych Lokalnych oraz System Analiz Samorządowych. Przeprowadzone w 2011 roku badania z wykorzystaniem kwestionariusza wywiadu, pozwoliły na określenie kierunków działań, jakie podejmują władze badanych gmin w dążeniu do osiągnięcia zrównoważonego rozwoju.
Rola public relations w promocji usług w przedsiębiorstwach funkcjonujących w Polsce
Authors: Łapińska Justyna , Pawlak-Kołodziejska Katarzyna
Published: October 2024

W działaniach promocyjnych usług na szczególną uwagę zasługuje public relations. Jest to instrument, który wyróżnia się tym, że nie jest skierowany wyłącznie na zachowania klientów, ale dąży do wzbudzenia zainteresowania usługą i firmą, która ją świadczy oraz w dalszej kolejności do budowania długotrwałych, opartych na zaufaniu relacji. Celem niniejszego artykułu jest ocena znaczenia działań public relations w promowaniu usług w polskich przedsiębiorstwach. W artykule wykorzystano wyniki badania pt. „Stan i rozwój marketingu w przedsiębiorstwach funkcjonujących na terenie Polski”, zrealizowanego dzięki finansowemu wsparciu Ministra Nauki i Szkolnictwa Wyższego.
Problem społecznej odpowiedzialności w rolnictwie
Authors: Brodzińska Katarzyna
Published: October 2024

Celem artykułu jest prezentacja wyników badań dotyczących oceny poziomu odpowiedzialności społecznej rolników - beneficjentów programu rolnośrodowiskowego. Badania przeprowadzono w 2011 r. na obszarze województwa warmińsko-mazurskiego i objęto nimi reprezentatywną próbę 588 rolników (8,5% ogółu rolników realizujących zobowiązania rolnośrodowiskowe). W badaniach zastosowano metodę sondażu diagnostycznego. Z przeprowadzonych badań wynika, że przyjęte kryteria kontroli gospodarstw realizujących zobowiązania programu rolnośrodowiskowego nie gwarantują stosowania przyjaznych środowisku praktyk gospodarowania, a istniejący system wsparcia finansowego w ograniczonym zakresie przyczynia się do realizacji celów WPR. Poziom zrównoważenia środowiskowego i społeczno-gospodarczego (udział zbóż w strukturze zasiewu
WHY DO THE UNIVERSITY GRADUATES SETTLE DOWN IN THE UNIVERSITY TOWN? POTENTIAL IMPLICATIONS FOR CITY MARKETING -THE CASE OF CRACOW
Authors: Brańka Sebastian
Published: October 2024

The background of the paper is place marketing, as a concept of territorial unit management aimed at customer satisfaction. In the paper it was underlined that one of the key factors that contemporary cities need for their development is human capital. Furthermore the author of the paper refers to place marketing publications to present the idea of city markets, where cities compete for gaining necessary resources. It is worth mentioning that the current competition between the cities is of global range. Therefore investors, new residents and tourists (being major markets for the cities to compete) choose cities from all over the world to meet their expectations. In the article special stress is made on students as a potential source of city’s new inhabitants. In the consecutive parts of the paper the author introduces the conclusions from a 2011 research supervised by the author and conducted on a significant group of students of Cracow University of Economics. The purpose of the research project was to identify the factors increasing attractiveness of the city for settling down after university graduation. The students were asked on their plans regarding their permanent residence after graduation and factors stimulating the decision to stay in the same city.
Turystyka wiejska – Pomorze 2013. Problemy ekonomiczne i zarządzania marketingowego
Authors: Feczko Janusz
Published: October 2024

Zachowania konsumenckie turystów mieszkańców Pomorza (Polska 2013) w zakresie turystyki wiejskiej w tym samym regionie są kształtowane przez ich postawy i preferencje: ich badania określiły elementy rozwoju zarządzania marketingowego gospodarką turystyczną wiejską. Poprzez zarządzanie marketingowe produkty turystyczne powinny być różnicowane i wzbogacane na bazie endogenicznych walorów regionu. W polityce cenowej pomocnym są wielorakie sposoby aktywizacji sprzedaży, w komunikacji marketingowej użytecznym są nie – i standardowe narzędzia promocji. Zarządzanie turystyką wiejską wymaga wiedzy i stosowania mechanizmów ekonomicznych, treści i technik zarządzania marketingowego.
Koncepcja zaufania w relacji lekarz-pacjentów świetle badań jakościowych
Authors: Krot Katarzyna , Rudawska Iga
Published: October 2024

Zaufanie pomiędzy lekarzem a pacjentem oprócz zdolności do budowania trwałych relacji, modelowania zachowań obu partnerów, ma także wartość terapeutyczną. Mimo coraz szerszego zainteresowania tym zagadnieniem nadal wymaga ono pogłębionych badań. Stąd celem niniejszego artykułu jest stworzenie koncepcji zaufania w relacji lekarz-pacjent w oparciu o wyniki badania jakościowego – analizę treści for internetowych. Okazało się, że zaufanie do lekarza jest efektem przenikana się i nakładania się na siebie dwóch poziomów: zaufania w skali makro i w skali mezo. Zaufanie w skali makro można traktować jako kontekst, w którym „zagnieżdżone” są wymiary zaufania instytucjonalnego. Natomiast zaufanie w skali mezo (instytucjonalne) jest postrzegane przez pryzmat trzech wymiarów: życzliwości, kompetencji i rzetelności.
Ekologizacja Wspólnej Polityki Rolnej –zagadnienia prawne
Authors: Król Monika
Published: October 2024

Pierwotne cele Wspólnej Polityki Rolnej (WPR) pozostają niezmienne od lat pięćdziesiątych ubiegłego stulecia. Jednakże w odniesieniu do polityki rozwoju obszarów wiejskich oraz artykułujących ją założeń prawnych zauważalne jest zintegrowane z koncepcją zrównoważonego rozwoju. Celem niniejszego opracowania jest próba wskazania podstaw prawnych włączenia instrumentów ochrony środowiska do regulacji normującej założenia WPR, ukazanie ewolucji rozwiązań prawnych w tym zakresie oraz na podstawie przeprowadzonej analizy dokonanie oceny założeń kolejnego etapy programowania tej polityki.
Problemy delimitacji małych gospodarstw rolnych w aspekcie projekcji zmian WPR na lata 2014-2020
Authors: Musiał Wiesław , Sroka Wojciech
Published: October 2024

Nadal trwają intensywne prace nad przygotowaniem projekcji Wspólnej Polityki Rolnej na lata 2014-2020. Ważnym i nowym aspektem wspierania rolnictwa będzie specjalne wsparcie skierowane do gospodarstw drobnych oraz małych. Zajmują one w wielu krajach, zwłaszcza Europy środkowo-wschodniej znaczące ekonomicznie i ważne społecznie miejsce w strukturze rolnictwa. W opracowaniu dokonano próby prostego, wieloaspektowego i przydatnego do celów aplikacyjnych zdefiniowania gospodarstw drobnych oraz małych, wobec których mają być zastosowane specjalne instrumenty wsparcia. Przeprowadzone analizy wykazały, iż gospodarstwa drobne należy definiować jako jednostki o powierzchnia od 1 do 5 ha UR, natomiast gospodarstwa małe za pomocą wielkości ekonomicznej. Proponuje się aby za podmioty małe uznać te, których wielkość ekonomiczna jest nie mniejsza niż 2 tys. euro SO i mniejsza niż 8 tys. euro SO.
Humanitarian Parole to the United States: The Case of a Gay Man Fleeing Afghanistan
Authors:   Law Office of Melanie Shapiro, USA, Shapiro Melanie
Published: October 2024

This article will discuss my experience as an immigration attorney representing a gay man from Afghanistan fleeing the Taliban. First, it will give an overview of the Taliban’s role in Afghanistan and the Taliban takeover in August 2021. It will then discuss the treatment of lesbian, gay, bisexual, and transgender (LGBT) individuals in Afghanistan. Next, the article will discuss how I became involved in representing individuals fleeing Afghanistan and the humanitarian parole process.
The Succesful of Student Well-Being Development Through Child-Friendly School Programs
Authors: Mangestuti Retno , Mulyadi Mulyadi , Wahyuni Esa Nur , Aziz Rahmat , Qudzy Saifuddin Zuhri
Published: October 2024

The paradigm shift in education has stimulated the emergence of new issues regarding the focus of education, including student wellbeing. The well-being of students at school will have a significant impact on their academic success and socio-emotional and health development. One of the efforts to improve student welfare is the child-friendly school program. This study aims to analyze the success of child-friendly schools in developing student welfare by using the method of observation and interviews with principals, vice-principals, teachers, and academic staff in one of the elementary schools. The data were analyzed using theme analysis techniques. The results of this study indicate that a school model that can develop student welfare is a school that, in the process of its implementation, there is a learning pattern that favors students, a pattern of humanistic social relations among school residents, as well as environmental support and infrastructure that is friendly to students. This study implies that policies in educational practice must be able to cloud the implementation of child-friendly schools, which can be a solution to developing student wellbeing.
Online Project-based Learning Integrated Quizizz as a Formative Assessment to Trigger High Order Thinking Skills
Authors: Mahendra I Wayan Eka
Published: October 2024

The Covid-19 pandemic has caused various impacts in the learning process, one of which is learning loss. Learning loss will directly and indirectly affect higher order thinking skills. This study aims to analyze the difference in HOTS between students who take Online Project-based Learning integrated quizizz as a formative assessment and HOTS students who take regular online learning. This study involved a population of 129 people and a sample of 39 people who were determined by random sampling technique. This type of research is a quasi-experimental research, with a non-equivalent control group design. The instrument used to collect data is the HOTS test in the form of a description. The data obtained were analyzed using one-way ANOVA, which had previously been tested for prerequisites. All data analysis using the help of IBM's SPSS for Windows 16.0. The results of data analysis show that there are differences in HOTS between students who take Online Project-based Learning integrated quizizz as a formative assessment and HOTS of students who take regular online learning. For this reason, teachers are expected to apply Quizizz's integrated Online Project-based Learning as a formative assessment in learning to obtain maximum higher-order thinking skills.