bluuebunny/crossref_metadata_2025 huggingface dataset:
Persepsi Peserta PPG dalam Jabatan terhadap Pelaksanaan Program PPG Hybrid Learning Bidang Studi Matematika Universitas Negeri Jakarta Tahun 2019
Authors: Tri Murdiyanto
Published: September 2020

Pendidikan dan Latihan Profesi Guru (PLPG) mulai tahun 2018 sudah tidak dilaksanakan dengan alasan kurang adanya relevansi terhadap peningkatan profesionalitas guru. Pendidikan Profesi Guru (PPG) dirancang untuk menggantikan PLPG yang mulai dilaksanakan tahun 2016 yaitu PPG SM3T (Sarjana Mendidik di Daerah Terdepan, Terluar, dan Tertinggal) dimana pesertanya adalah para guru yang sudah melaksanakan tugas mengabdi di daerah 3T. Tahun 2018 dilaksanakan PPG Prajabatan bersubsidi dan tahun 2019 mulai dilaksanakan PPG dalam Jabatan. PPG SM3T dan Prajabatan bersubsidi dilaksanakan secara tatap muka tetapi PPG dalam jabatan dilaksanakan menggunakan sistem Hybrid learning yang perupakan gabungan dari system daring dan sistem tatap muka dengan pertimbangan bahwa pesertanya adalah guru yang juga mempunyai tugas di sekolah sehingga tidak dapat terlalu lama meninggalkan tugas. Masalah yang muncul adalah apakah sistem PPG ini cocok untuk kondisi di Indonesia yang merupakan negara kepulauan dimana fasilitas pembelajarannya belum bisa merata dan apakah para guru siap untuk belajar secara daring. Tujuan penelitian ini adalah untuk mendapatkan masukan dari peserta PPG dalam jabatan terhadap pelaksanaan PPG Hybrid Learning bidang studi matematika Universitas Negeri Jakarta tahun 2019. Metode penelitian yang digunakan adalah metode deskriptif, fokus penelitian pada persepsi peserta PPG terhadap pelaksanaan program PPG dalam jabatan Hybrid Learning. Persepsi peserta PPG yang diukur terdiri dari dua bagian yaitu 1) penerimaan atau penyerapan dan 2) evaluasi terhadap proses yang dijalani selama program dilaksanakan. Subyek penelitian ini adalah peserta PPG dalam jabatan bidang studi matematika FMIPA UNJ tahun 2019 tahap 1 sampai tahap 4 tahun 2019. Teknik pengumpulan data dengan menyebarkan angket kepada responden. Angket yang digunakan berupa gabungan angket tertutup dan terbuka yaitu tertutup dalam bentuk pernyataan yang pilihan jawabannya sudah disediakan sedangkan terbuka untuk mendapatkan masukan mengembangkan proses pelaksanaan program PPG bidang studi matematika FMIPA UNJ. Hasil penelitian menunjukkan penerimaan atau penyerapan pada saat daring: kemudahan memperoleh sinyal internet, kemudahan menjalankan aplikasi, memahami capaian pembelajaran PPG, ketersediaan sumber belajar, kemampuan menyelesaikan tugas dan evaluasi persentase yang menyatakan setuju dan sangat setuju lebih dari 80% namun yang tertarik/tertantang dengan pembelajaran daring hanya 40 % dan yang merasakan beban sangat berat dalam pelaksanaan pembelajaran daring sebesar 75%. Evaluasi proses yang menyangkut kesesuaian materi dan capaian pembelejaran, kesesuaian tugas dan evaluasi dengan materi, kemampuan dan kinerja instruktur, pelayanan administrasi, fasilitas yang memadahi, kemudahan pelaksanaan PPL dan kecukupan durasi waktu PPL persentase setuju dan sangat setuju diatas 75 %. Tetapi untuk kecukupan durasi waktu daring dan porsi materi hanya 55% yang setuju dan sangat setuju.
Analisis Survival dengan Model Regresi pada Data Tersensor Berdistribusi Log-Logistik
Authors: Kusumawardhani Gatri Eka , Santi Vera Maya , Suyono Suyono
Published: September 2020

Survival analysis is an analysis used to determine the length of time required by an object in order to survive. That time is sometimes influenced by several factors called independent variables. One way to know relationship is through a regression model. The dependent variable in this regression model is a survival time which is log-logistic distributed. The data used in this study were right censored survival data. Log-logistic regression models for survival data can be expressed by transformation Y=lnT= Î¸0+Î¸1xi1+...+Î¸ixij+ÏƒÔ‘. The parameter of the log-logistic regression models for right censored survival data are estimated with the maximum likelihood method. In this study, the application of log-logistic regression model for survival data is in data of lung cancer patients. Based on the data already performed, best log-logistic regression model is obtained yi=1.92458+0.0242393 xi1+0.639037Ô‘i.
PENGEMBANGAN MODEL LATIHAN BUILD UP MENYERANG PADA PERMAINAN FUTSAL
Authors: Paranoan Andri , Prastya Ardi Nur
Published: September 2020

ABSTRAK

Penelitian ini bertujuan untuk mengembangkan model latihan Build up menyerang pada permainan futsal menjadi sesuai dengan teori prinsip-prinsip Build up menyerang. Metode yang digunakan dalam penelitian ini adalah metode penelitian dan pengembangan (research and development). Subjek pada penelitian ini adalah 15 anggota tim futsal Kiangsantang sebagai subjek uji coba kelompok kecil dan 45 anggota tim futsal Universitas Negeri Jakarta sebagai subjek uji coba kelompok besar. Pada penelitian ini peneliti bekerja sama dengan 3 ahli dalam bidang olahraga futsal sebagai expert judgement. Uji validitas yang digunakan pada penelitian ini adalah dengan menggunakan uji justifikasi ahli. Berdasarkan uji validasi dari 25 item model latihan Build up menyerang pada permainan futsal didapat 20 model latihan Build up yang valid berdasarkan uji justifikasi ahli

Kata Kunci : Model Latihan, Build Up, Futsal

ABSTRACT

 This study aims to develop a Build up attacking model on futsal games to be in line with the theory of Build up attacking principles. The method used in this research is the method of research and development (research and development). Subjects in this study were 15 members of Kiangsantang futsal team as the subject of small group trials and 45 members of futsal team of Universitas Negeri Jakarta as subject of large group trials. In this study the researchers worked together with 3 experts in the field of futsal sport as an expert judgment. Validity test used in this research is by using expert justification test. Based on the validation test of 25 items of training model Build up attack on futsal game obtained 20 models of valid Build up exercise based on expert justification test.

 Keywords: Exercise Model, Build Up, Futsal
SURVEI PELAKSANAAN PEMBELAJARAN PENDIDIKAN JASMANI ADAPTIF DI SLB C PROVINSI DKI JAKARTA TAHUN 2019
Authors: Sukriadi Slamet , Arif Muhamad
Published: September 2020

ABSTRAK

 

Penelitian ini bertujuan untuk mengetahui pelaksanaan pembelajaran Pendidikan Jasmani Adaptif di SLB C Provinsi DKI Jakarta yang dilihat dari factor tujuan pembelajaran, materi pembelajaran, kompetensi guru, sarana dan prasarana serta evaluasi pembelajaran. Penelitian ini merupakan penelitian deskriptif kuantitatif. Metode yang digunakan adalah survei. Populasi dan sampel penelitian ini adalah 36 guru Pendidikan Jasmani Adaptif SLB C di Provinsi DKI Jakarta. Variable penelitian ini adalah pelaksanaan pembelajaran Pendidikan Jasmani Adaptif di SLB C Provinsi DKI Jakarta data dikumpulkan dengan menggunakan Instrumen yang berupa kuesioner berjumlah 29 butir pertanyaan. Teknik analisis data menggunakan deskriptif kuantitatif.

Hasil penelitian menunjukkan bahwa pelaksanaan pembelajaran Pendidikan Jasmani Adaptif SLB C Provinsi DKI Jakarta tahun 2019 sebanyak 6,67% dalam kategori tidak baik, 16,67% dalam kategori kurang baik, 38,89 kategori cukup, 36,11% dalam kategori baik dan 1,67% dalam kategori sangat baik. Dengan demikian dapat disimpulkan bahwa Pelaksanaan Pembelajaran Pendidikan Jasmani Adaptif di SLB C Provinsi DKI Jakarta tahun 2019 dalam kategori cukup.

 

Kata kunci: Pembelajaran, Pendidikan Jasmani Adaptif, SLB C

 

ABSTRACT

 

This study aims to determine the implementation of Adaptive Physical Education learning in SLB C DKI Jakarta Province which is seen from the factors of learning objectives, learning materials, teacher competencies, facilities and infrastructure as well as learning evaluation. This research is quantitative descriptive. The method used is a survey. The population and sample of this study were 36 Adaptive Physical Education teachers of C-SLB in DKI Jakarta Province. The variable of this research is the implementation of Adaptive Physical Education learning in SLB C DKI Jakarta Province data were collected using an instrument in the form of a questionnaire totaling 29 questions. Data analysis techniques using quantitative descriptive.

The results showed that the implementation of Adaptive Physical Education learning SLB C in DKI Jakarta Province in 2019 was 6.67% in the bad category, 16.67% in the poor category, 38.89 adequate category, 36.11% in the good category and 1 67% in the excellent category. Thus it can be concluded that the Implementation of Adaptive Physical Education Learning in SLB C DKI Jakarta Province in 2019 is in the sufficient category.

 

Keywords: Learning, Adaptive Physical Education, SLB C
ANALISIS INSIDE PASS TIM BOLA BASKET PUTERI UNIVERSITAS NEGERI JAKARTA PADA LIMA BASKETBALL NATIONALS 2019
Authors: Novanti Eliya , Sulaiman Iman , Apriyanto Tirto
Published: September 2020

ABSTRAK

 Penelitian ini bertujuan untuk mengetahui bagaimana inside pass tim bola basket putri Universitas Negeri Jakarta pada Liga Mahasiswa Basketball Nationals 2019. Metode dalam penelitian ini termasuk dalam metode deskriptif  dengan teknik pengambilan data observasi atau survei, populasi dalam penelitian ini adalah seluruh tim bola basket putri yang bertanding pada Liga Mahasiswa Basketball Nationals 2019 dan sampel yang di gunakan yaitu total sampling yaitu seluruh pemain putri Universitas Negeri Jakarta yang bertanding pada liga Mahasiswa Basketball Nationals yang berjumlah 12 orang. Berdasarkan hasil dari analisis Peneliti Inside Pass yang dilakukan oleh Universitas Negeri Jakarta inside pass yang dilakukan tim bola basket UNJ selama mengikuti Liga Mahasiswa Basketball Nationals 2019  sudah baik bagaimana  Inside Pass Ini tujuannya mengarahakan bola ke area circle lawan dan berusaha mencetak point dari jarak yang lebih dekat dengan ring tingkat keberhasilan mencapai 69% dan kegagalan 31% dan berdasarkan data yang diperoleh peluang untuk finishing rata-rata mecapai 71 kali atau 42%, Hasil analisis ini bisa dijadikan salah satu strategi oleh UNJ dalam membuat system penyerangan yang mengutamakan Inside Pass.

 Kata Kunci : Analisis,keberhasilan dan kegagalan, Inside Pass.

 ABSTRACT

  This study aims to determine how inside pass of the girl basketball team at University of Jakarta in the Basketball Nationals Student League 2019. The method in this study was included in the descriptive method with observation or survey data collection techniques. The population in this study were all girl basketball teams that competed in the Basketball Nation Student League 2019 and the sample used was total sampling, namely all girl players Universiyty of Jakarta who competed in the Basketball Nationals Student League, amounting to 12 people.Based on the results of the analysis of Inside Pass Researchers conducted by University of Jakarta while participating in the Basketball Nationals Student League 2019, it is good how Inside Pass aims to direct the ball at the opponent's circle area and try to score points from a distance that is closer to the ring, the success rate reaches 69% and 31% failure and based on the data obtained the opportunity for finishing on average reaches 71 times or 42% . The results of this analysis can be used as a strategy by University of Jakarta in creating an attack system that prioritizes Inside Pass.

 Keywords : Analysis, success and failure, Inside Pass.
Transformasi Kewenangan DPD Dalam Ius Constitutum Ke Arah Ius Constituendum Demi Kesetaraan Dalam Bikameral
Authors: Benyal Hariyanto Sofyan
Published: September 2020

After the reformation a change has occurs, a significant one, especially in the state administration as seen in the amendment, the 1945 constitution amendment, strengthening on the legislature in order to lift the power of checks and balances among the institutions, government agencies. On the third amendments in 2001 new institution, an institution of legislation appears in the Regional Representative Board (DPD to be the regional representation and later become a second chamber (bicameral) parliament which believed has made the legislation tasks such as, budgeting, and monitoring implemented optimally. But in reality, the duties and powers of the second chamber is still very limited compared to the first chamber which is the DPR, hence the transformation effort to ius consitutendum, the desirous law, appeared in strengthening the DPD constitutionally through MPR with Pancasila as the foundation. The method used is a normative juridical, by referring to the laws and principles exist. The analysis used in this research is descriptive qualitative analysis. The results shows that there is an inequality authorization in the, DPR and DPD, parliament. It gives a signal that the system we have adopted is a soft bicameral. By constant check and balance with Pancasila as the foundation DPD should be strengthen.
Problematika Online Single Submission Di Indonesia : Konflik Kewenangan Antara Pusat Dan Daerah
Authors: Mualim Arista Satryo Wicaksono
Published: September 2020

In order to facilitate the investment in Indonesia, the government of Indonesia issued the Government Regulation Number 24 year 2018 on licensing services attempted integrated electronically (OSS), this is done in order to increase the investment which is an important basis to improve the progress and welfare of the people of Indonesia, but the regulation on the OSS is apparently contrary to law No. 30 year 2014 about about. Government administration, and Law No. 9 year 2015 Second Amendment to Law No. 23 of 2014 on local government, this then resulted in a conflict between the legislation and regulations related to the authorization of business license, the author aims to examine and analyze the conflict of laws and regulations related to the authorization of business license by using normative juridical approach to find the legal certainty in the application of government Regulation Number 24 year 2018 concerning licensing services seeks electronically integrated (OSS).

 

Key words: Investment, Online Single Submission, Conflict of authority
Results of numerical modeling of flows in cellular structures of various species
Authors: Naprasnikov V. V. , Polozkov V. V. , Borodulya A. V. , Kunkevich D. P.
Published: September 2020

When creating cellular structures, one of the tasks is to study the flows of liquids in the cavities of structures in order to obtain data on the velocities, pressures, and features of the current lines. The properties of cellular structures depend on the geometry of the cavities and their relative position.

The article describes the sequence of stages of modeling fluid flow in the cavities of cellular structures and the results of variant calculations for various types of such structures.
URGENSI MERATIFIKASI FRAMEWORK CONVENTION ON TOBACCO CONTROL (FCTC) DALAM UPAYA PENGENDALIAN KONSUMSI TEMBAKAU DI INDONESIA
Authors: Kurniawan Fajar
Published: September 2020

Masalah konsumsi tembakau saat ini telah menjadi issu global yang mencakup hampir semua aspek kehidupan baik aspek ekonomi, sosial maupun kesejahteraan masyarakat, khususnya bagi aspek kesehatan karena dampak kerugian kesehatan yang ditimbulkannya. Konsumsi rokok di Indonesia terus mengalami peningkatan yang signifikan. Indonesia merupakan negara ketiga dengan jumlah perokok tertinggi di dunia. Pengendalian konsumsi tembakau secara global telah dituangkan dalam Framework Convention on Tobacco Control (FCTC) sejak tahun 2003, namun hingga saat ini Indonesia belum melakukan pengesahan terhadap FCTC tersebut. Sebagai bagian dari peradaban masyarakat internasional, maka sudah selayaknya Indonesia mendukung upaya perlindungan masyarakat dari bahaya konsumsi tembakau dengan segera mengesahkan FCTC menjadi Undang-Undang. Hal ini sangat diperlukan mengingat upaya perlindungan kesehatan masyarakat tersebut merupakan bagian dari penegakan Hak Asasi Manusia di bidang kesehatan.
Establishment of a Predictive Model for Factors Related to Systemic Inflammatory Response Syndrome (SIRS) after Percutaneous Nephrolithotomy (PCNL)
Authors: Ju Min , Zheng Jin , Gao Lin Lin , Pan Li Ying
Published: September 2020

Background: Percutaneous nephrolithotomy (PCNL) is a primary treatment method for renal stones, but infection is a very common postoperative complication. Systemic inflammatory response syndrome (SIRS) is a stage of the infection process and a very important early clinical manifestation of sepsis, so identifying the risk factors associated with SIRS after PCNL is important for ensuring patient safety and preventing sepsis.Objective: To analyze the risk factors for SIRS after PCNL, identify the predictive factors, and perform risk factor analysis.Methodology: Between September 2016 and September 2017, 352 patients who were diagnosed with renal stones and treated with PCNL were included in this study. The patients were divided into two groups according to whether SIRS occurred. Univariate analysis was performed on the related risk factors, including patient age; gender; body mass index; urine culture; number, types and quantity of rental stones; diabetes; blood glucose; complications; hospital stay; residual stones; and Guy’s degree. Then, logistic regression was used to perform multivariate analysis and establish a predictive model.Results: A total of 352 patients with renal stones were treated with PCNL, and 106 patients (30.1%) developed SIRS after surgery. Operative time, preoperative fever and diabetes were found to be risk factors, and the logistic regression results indicated that diabetes (OR=2.049, 95%CI 1.008~4.166) and operative time (OR=1.011, 95%CI 1.003~1.019) could be entered into the regression equation. Therefore, the predictive regression model was P=1/[1+e-(-2.097+0.712 diabetes + 0.012 operative time)].Conclusion: Diabetes and operative time are independent risk factors for SIRS after PCNL, so the probability of SIRS after PCNL can be determined according to these two indicators.
Investigating knowledge, attitudes, and practices related to COVID-19 outbreak among Bangladeshi young adults: A web-based cross-sectional analysis
Authors: Banik Rajon , Rahman Mahmudur , Sikder Md. Tajuddin , Rahman Quazi Maksudur , Pranta Mamun Ur Rashid
Published: September 2020

Aim: This study aimed to assess knowledge, attitudes, and practices (KAP) towards COVID-19 among young adults in Bangladesh. Subject and Methods: A cross-sectional survey was conducted from 5th May to 25th May 2020. Young adults aged between 18-35 years were approached via social media to complete an online questionnaire consisted of socio-demographic characteristics and KAP towards COVID-19. Descriptive statistics, t-tests, one-way analysis of variance (ANOVA), and multiple logistic regression were conducted.Results: Of the 707 survey participants, the majority were male (57.1%), with a mean age of 25.03 (SD: 4.26) years, 60.3% were students, 57% had a bachelor's degree, and 64.4% were urban residents. Participants gather information on COVID-19 mostly through Social media (70.4%). Overall, 61.2% had adequate knowledge with 78.9% having a positive attitude towards COVID-19 and only 51.6% had good practices. Most (86.8%) of the participants were confident that COVID-19 will be successfully controlled and Bangladesh was handling the COVID-19 health crisis well (84.20%). Only 75.2% of participants always washed hands with soap or hand-sanitizer and 70.6% wore a mask when going outside the home in recent days. Factors associated with adequate knowledge were being female, having a master's degree and above, and living in an urban area (𝑝 < 0.05). Participants having adequate knowledge of COVID-19 had higher likelihood of positive attitudes (OR: 6.41, 95% CI = 2.34-25.56, 𝑝 = 0.000) and good practices (OR: 8.93, 95% CI = 3.92-38.42, 𝑝 = 0.000).Conclusion: Introducing effective COVID-19 Health campaigns incorporating factors to influence KAP is urgently needed.
Worldwide inverse correlation between Bacille Calmette-Guérin immunization and COVID-19 mortality
Authors: Li Willis X.
Published: September 2020

The coronavirus disease 2019 (COVID-19) pandemic has spread to all countries in the world after more than half a year since it was first reported in late 2019, and different countries have been impacted differently. Multivariate statistical analyses were used to evaluate COVID-19 deaths and cases relative to nine other demographic and socioeconomic factors in all countries and regions of the world using data as of August 1, 2020. The factors analyzed in the study include a country’s total COVID-19 deaths and cases per million population, per capita gross domestic product (GDP), population density, virus tests per million population, median age, government response stringency index, hospital beds availability per thousand population, extreme poverty rate, Bacille Calmette-Guérin (BCG) vaccination rate, and diphtheria-tetanus-pertussis (DTP3) immunization rate. The study reveals that COVID-19 deaths per million population in a country most significantly correlates, inversely, with the country’s BCG vaccination rate, and also significantly correlates a country’s per capita GDP and median age, while COVID-19 cases per million population significantly correlate with per capita GDP and tests per thousand population. This study contributes to a growing body of evidence supporting the notion that BCG vaccination may be protective against COVID-19 mortality.
The Immunogenicity and Immunoprotection Identification of Adhesion Protein 65 (AP65) of Trichomonas Vaginalis
Authors: Zhang Zhenchao , Song Xiaoxiao , Zhang Zhengbo , Li Haoran , Duan Yujuan , Zhang Hao , Lu Haoran , Luo Chengyang , Wang Shuai , Wang Mingyong
Published: September 2020

Background: Adhering to the epithelial lining along the urogenital track of the host is the prerequisite for Trichomonas vaginalis (T. vaginalis) to inflict its parasitism and pathogenicity, causing urogenital infection. The AP65 of T. vaginalis (TvAP65) involves in the process of adhesion. So, the present study was aimed at investigating the molecular characterization and vaccine candidacy of TvAP65 for protecting the host from the onset of Trichomoniasis.Methods: The open reading frame (ORF) of TvAP65 was amplified and then inserted into pET-32a (+) to clone recombinant TvAP65 (rTvAP65). The immunoblotting determined the immunogenicity and molecular size of TvAP65, while immunofluorescence staining visualized and the precise localization of TvAP65 in T. vaginalis trophozoites. The animal challenged with the enzyme-linked immunosorbent assay (ELISA ) test was used to evaluate the immunoprotection and the types of the immune response of TvAP65.Results: By the sequence analysis, TvAP65 encoded a 63.13 kDa protein that aligned 567 amino acid residues together with a high antigenic index. The western blotting then revealed that rTvAP65 and native TvAP65 could interact with the antibodies in the rat serums post hoc rTvAP65 immunization and the serums from the mice that were experimentally infected with T. vaginalis, respectively. Immunofluorescence stained TvAP65 on the surface of T. vaginalis trophozoites. Moreover, following emulsification with Freund’s adjuvant, rTvAP65 was subsequently administered to BALB/c mice three times at 0, 2, and 4 weeks and the results from this animal challenge experiments showed significant increases in immunoglobulins of IgG2a, IgG1, and IgG, and proinflammatory factors of IFN-γ, and IL-2, and 10. Lastly, rTvAP65 vaccinated animals had a prolonged survival time (26.80 ± 4.05) after challenged by T. vaginalis. Conclusions: TvAP65 mediated the adhesion of T. vaginalis to the host epithelia for the pathogenesis of the parasite and can be considered as a candidate protein for designing a functional vaccine that induces cell-mediated and humoral immunity against the T. vaginalis infection.
Contextualising the Pharmacist Practicing Clinical Pharmacy in South Africa – Do we Practice What we Preach?
Authors: Bronkhorst Elmien , Schellack Natalie , Gous Andries GS
Published: September 2020

Background: The National Department of Health published their Quality Standards for Healthcare Establishments in South Africa and introduced the National Health Insurance (NHI), with the pilot phase that commenced in 2012. The system requires an adequate supply of pharmaceutical personnel and the direct involvement of clinical pharmacists throughout the medication-use process to ensure continuity of care, minimised risk with increasing improvement of patient outcomes. The study aimed to provide insight into the pressing issues of clinical pharmacy practice in South Africa, and sets out to contextualise the current profile of the pharmacist performing clinical functions.Methods: The study used a quantitative, explorative, cross-sectional design. The population included pharmacists from private and public tertiary hospitals. A questionnaire was administered, using Typeform™. Ethics approval was obtained from relevant role-players. Categorical data were summarised using frequency counts and percentages; continuous data were summarised by mean values and standard deviations.Results: The sample size included 70 pharmacists (private sector n=59; public sector n=11). Most participants hold a BPharm degree (64%; n=70). No statistical significance was found between participants in private and public practice. Most pharmacist agreed (32% (private); n=59) and strongly agreed (45% (public); n=11) to have sufficient training to perform pharmaceutical care. The majority respondents felt that interventions made by the pharmacist improved the rational use of medicine (47% (private); n=59; 55% (public); n=11), that pharmacist interventions influence prescribing patterns (42% (private); n=59; 64% (public); n=11) and reduce polypharmacy (41% (private); n=59; 55% (public); n=11). Clinical functions performed most are evaluation of prescriptions (private 90%; public 82%) while the top logistical function for private is daily ordering of medication (40.7%), and public checking of ward stock (36%).Conclusion: Although not all pharmacists appointed in South Africa has completed the MPharm degree in clinical pharmacy, the pharmacists at ward level perform numerous clinical functions, even if only for a small part of their workday. This paper sets the way to standardise practices of clinical pharmacy in South Africa, with a reflection on the differences in practice in different institutions.
Safety and Efficacy of Hypofractionated Stereotactic Radiosurgery for High-Grade Gliomas at First Recurrence: A Single-Center Experience
Authors: Guan Yun , Xiong Ji , Pan Mingyuan , Shi Wenyin , Li Jing , Zhu Huaguang , Gong Xiu , Li Chao , Mei Guanghai , Liu Xiaoxia , Pan Li , Dai Jiazhong , Wang Yang , Wang Enmin , Wang Xin
Published: September 2020

Background: The optimal treatment for recurrent high-grade gliomas (rHGG) remains uncertain. This research aimed to investigate the efficacy and safety of CyberKnife radiosurgery as a salvage treatment for high-grade gliomas at first recurrence that within the radiation field.Methods: Between January 2016 and October 2019, rHGG patients treated with CyberKnife radiosurgery were retrospectively analyzed. The primary endpoint was OS, and secondary endpoints included progression-free survival (PFS) and toxicity. Toxicity was assessed using CTCAE 5.0. The prognostic value of key clinical features (age, performance status, planning target volume, dose, use of bevacizumab) were evaluated.Results: A total of 70 patients were included in the study. Forty patients were male and 30 were female. Forty-nine had an initial diagnosis Glioblastoma (GBM), and rest (21) were WHO Grade 3 Gliomas. The median planning target volume (PTV) was 16.68 cm3 (0.81–121.96 cm3). The median prescribed dose was 24 Gy (12-30 Gy) in 4 fractions (2-6 fractions). Median baseline Karnofsky Performance Status (KPS) is 70 (40-90). With a median follow-up of 12.1 months, the median overall survival after salvage treatment was 17.6 months (19.5 and 14.6 months for grade 3 and 4 gliomas; p = 0.039). No grade 3 or higher toxicities was recorded. Multivariate analysis showed concurrent bevacizumab with radiosurgery and KPS>70 were favorable prognostic factors for grade 4 patients.Conclusions: Salvage CyberKnife radiosurgery showed a favorable outcome and acceptable toxicity for rHGG. A prospective phase II study (NCT04197492) is ongoing to further investigate the value of HSRS in rHGG.
WITHDRAWN: Optimization of process parameters for the green synthesis of silver nanoparticles using Plackett-Burman and 3-level Box–Behnken Design
Authors: R Halima , Narula Archna , Sivakiran R.R
Published: September 2020

Background:
The present work describes the synthesis of silver nanoparticles (AgNps) from leaf extracts of Piper betle and Jatropha curcas using a green approach. Green synthesis of nanoparticle is superior over other methods of synthesis as it is ecofriendly and cost effective. The phytochemical components in the leaf extract play a vital role in reducing the AgNO3 and hence synthesizing the silver nanoparticles. During this reduction activity, the several factors which affect the synthesis of nanoparticles were investigated and optimized according to the yield of nanoparticles. The experimental conditions investigated were pH, temperature, pressure, time of reaction, microwave radiation, UV radiation and concentration of plant extract, silver nitrate & sunlight. Satisfactory yields of silver nanoparticles synthesis from plant extract were obtained by using optimum conditions when compared to conventional synthesis of nanoparticles. The optimization parameter was later
Result:
A mathematical model was formulated to correlate the interactive influence of the parameters and the significant reduction. Plackett-Burman design (PBD) indicated that concentration of plant extract, concentration of silver nitrate and sunlight were the major parameters affecting the synthesis of silver nanoparticle. The mutual interactions of these variables are mapped in the design by 3 Box-Behnken design (BBD). The significant factors and their interactions in the green synthesis were examined by analysis of Variance (ANOVA). The result indicated that the BBD was a good predictive model for the experimental results. Though the plant extracts are different, the characterization of the synthesized nanoparticle after optimization of parameters showed uniform size and shape i.e. spherical shape and size of 41 nm.
Conclusion:
The silver nanoparticles were synthesized under different optimization parameters were uniformly shaped (spherical) and sized (41 nm) particles. The mathematical models Plackett-Burman and Box-Behnken helped in analyzing the impact of the optimization parameters.
Applying an Interspersed Online and Offline Teaching Strategy in Medicinal Chemistry to Cultivate Research Interest and Innovation Skills in Undergraduate Pharmacy Students
Authors: Ying Huazhou , Liu Tao , Sheng Rong , Chen Wenteng , Dong Xiaowu
Published: September 2020

Background: Medicinal chemistry is one of the most important professional courses for undergraduate pharmacy students. It plays an essential role in the cultivation of innovative pharmaceutical talents, especially for drug discovery and development. Methods: We present here a new teaching system that integrates a cloud-based teaching platform, as well as applying an interspersed online and offline teaching strategy in an undergraduate medicinal chemistry course. Results: The innovative teaching mode increases undergraduates' interest and understanding of medicinal chemistry topics as well as the frontiers and technologies in new drug discovery. Furthermore, it promotes effective communication between teachers and students resulting in increased research interest and innovation skills of undergraduates.
Psychosocial Healthcare Centres (CAPS) in Brazilian Mental Health Policy, 2008-2017
Authors: Barbosa Rafael da Silva , Garcia Maria Lucia Teixeira , Spolander Gary C , Oliveira Edineia Figueira dos Anjos
Published: September 2020

Psychosocial Healthcare Centres have been promoted by Brazilian mental health policy along with a guaranteed financing from the Ministry of Health. This paper used Strata 2014 data to analyse the extent of Psychosocial Healthcare Centres care capacity available for user as the central driver of mental health care in Brazil. Retrospective, descriptive study with secondary data analysis of services was undertaken using data from Brazilian federal government databases. Brazil does not have 100% mental health care coverage and our analysis, using the Brazilian Health Ministry criteria, identified only 36% (842) municipalities have been adequately resourced. Our analysis identified that while the number of CAPS units increased around 100%, due to increased extra-hospital and community services in the period, effective cover reduced due to budget cuts and increases as a result of rights to access. The Ministry of Health identified coverage in the ratio of 1 CAPS / 100 thousand inhabitants, although CAPS availability is not the only parameter for assessing mental health coverage. Within municipalities, the mental health network is not synonymous with CAPS nor its quality. We believe that the priority given to investing in CAPS, without guaranteeing resources for other mental health intervention, may negate the efforts of building of a network of new de-institutionalising services which replaced traditional models.
Plasmodium Falciparum Regulates Transcriptional Output by Modulating The Activity of RNA Polymerase II Rather Than Its Recruitment
Authors: Khandelia Ragini Rai , Mohan Aarthi , Zhu Lei , Zheng Jie , Featherstone Mark Stephen , Bozdech Zbynek
Published: September 2020

Background The asexual phase of the unicellular eukaryotic parasite Plasmodium falciparum takes place in the human red blood cell (RBC). During the 48 h between RBC infection and the release of new progeny – the intraerythrocytic developmental cycle (IDC) – transcripts levels for most of the parasite’s ~5,772 genes are set by the integration of transcriptional and post-transcriptional processes. Transcription of eukaryotic protein coding genes is carried out by RNA polymerase II (RNAPII) whose functional states are reflected by the phosphorylation status of serine residues at positions 2 and 5 within the so-called heptad repeats within the C-terminal domain (CTD) of the catalytic subunit, RPB1; unphosphorylated or Ser5-phosphorylated RNAPII correspond to uninitiated and initiating states, while phosphorylation at Ser2 is associated with the processive elongating form of the polymerase. Transcriptional control over the IDC could impinge on RNAPII recruitment, initiation, and conversion to processive elongation. To distinguish the contribution of these potential regulatory steps to transcriptional control during infection, we used ChIP-seq and RNA-seq to determine the genome-wide distribution of three RNAPII phosphoisoforms as well as total RNAPII and correlated occupancy with mRNA levels across the three stages of the IDC.ResultsWe find that most genes are occupied by RNAPII along the length of the coding region at all stages of the IDC, regardless of transcript output, with RNAPII accumulation of all forms strongly biased toward the coding region. Total RNAPII levels at a given gene are relatively constant across the IDC. By contrast, occupancy by the elongating form of the polymerase shows a strong positive correlation with mRNA abundance. ConclusionsThese observations reveal that transcriptional activation during the IDC is not regulated primarily at the level of RNAPII recruitment, but rather through the conversion of RNAPII to its processive elongating form. Our results have implications for the expected roles of enhancers and transcription factors in the parasite and support a major role for the control of transcriptional pausing.
Evaluating Context-Specific Evidence-Based Quality Improvement Intervention on Lymphatic Filariasis Mass Drug Administration in Northern Ghana using the RE-AIM Framework.
Authors: Manyeh Alfred Kwesi , Chirwa Tobias , Ramaswamy Rohit , Baiden Frank , Ibisomi Latifat
Published: September 2020

BackgroundOver a decade of implementing a global strategy to eliminate lymphatic filariasis in Ghana through mass drug administration, the disease is still being transmitted in 22 districts out of an initial 98 endemic districts identified in 2000. A context-specific evidence-based quality improvement intervention was implemented in the Bole District of Northern Ghana after an initial needs assessment. This study aimed to evaluate the process and impact of the intervention on implementation of lymphatic filariasis mass drug administration in Bole District of Northern Ghana. MethodThe study used the RE-AIM (Reach, Effectiveness, Adoption, Implementation, and Maintenance) framework based on a mixed-methods approach to evaluate the context-specific evidence-based quality improvement intervention. Results The findings of the evaluation showed that there was an improvement in social mobilization and sensitization, knowledge about lymphatic filariasis and mass drug administration process, willingness to ingest the medication, and adherence to the directly observe treatment strategy. We observed a 6.3% increase in the district mass drug administration coverage and reduction in self-reported adverse drug reaction. The level of reach, effectiveness and adoption as the district, sub-district and at the individual participants’ level suggest that the context-specific evidence-based quality improvement intervention is feasible to implement in LF hotspot districts based on initial context-specific needs assessment. ConclusionThe study provided the groundwork for future application of the RE-AIM framework to evaluate the implementation of context-specific evidence-based quality improvement intervention to improve mass drug administration towards the elimination of lymphatic filariasis as a public health problem.
Developing a Post- Graduate Curriculum In Forensic Psychiatry In Zimbabawe
Authors: Mangezi Walter , Mawoyo Chido , Shonai Charity , Aagaard Eva
Published: September 2020

In the practice of forensic psychiatry in Zimbabwe, there have been problems in bringing psychiatric offenders to justice due to delays in assessment. This has been caused by a shortage of psychiatrists with the relevant skills. Practitioners need to be equipped with the required competencies to deal with both the civil and criminal domains of forensic psychiatry. They also need neuropsychological tools for the evaluation of offenders and victims, and knowledge of the appropriate tests to be used in each case. To date, the Department of Psychiatry at the University of Zimbabwe has had no formal curriculum in forensic psychiatry. To meet these needs, a forensic psychiatry curriculum was developed. The goals for the curriculum were for the students to: 1) acquire knowledge in the assessment and management of psychiatric conditions and their relation to criminal and civil legal issues; 2) attain attitudes that foster a focus on assessment of the patients’ mental health, not their innocence or guilt; 3) write court reports that facilitate the justice process. In addition to improving the current shortage of qualified physicians in forensic psychiatry, this curriculum aims to increase awareness among psychiatry students of forensic psychiatry as a career path.
The Value of A Seven-Autoantibody Panel Combined With The Mayo Model In The Differential Diagnosis of Pulmonary Nodules 
Authors: Ling Zhougui , Chen Jifei , Wen Zhongwei , Wei Xiaomou , Su Rui , Tang Zhenming , Hu Zhuojun , Deng Youping
Published: September 2020

BACKGROUND: Identifying malignant pulmonary nodules and detecting early-stage lung cancer (LC) could reduce mortality. This study investigated the clinical value of a seven-autoantibody (7-AAB) panel in combination with the Mayo model for the early detection of LC and distinguishing benign from malignant pulmonary nodules (MPNs).METHODS: The concentrations of the elements of a 7-AAB panel were quantitated by enzyme-linked immunosorbent assay (ELISA) in 806 participants. The probability of MPNs was calculated using the Mayo predictive model. The 7-AAB panel and the Mayo model performances were analyzed by receiver operating characteristic (ROC) analyses, and the difference between groups was evaluated by Chi-square tests (χ2).RESULTS: The combined area under the ROC curve (AUC) for all 7 AABs was higher than that of a single one. The 7-AAB panel sensitivities were 67.5% in the stage I-II LC patients and 60.3% in stage III-IV patients, with a specificity of 89.6% for the healthy controls and 83.1% for benign lung disease patients. The detection rate of the 7-AAB panel in the early-stage LC patients was higher than that of traditional tumor markers. The AUC of the 7-AAB panel combined with the Mayo model was higher than that of the 7-AAB panel alone or the Mayo model alone in distinguishing MPN from benign nodules. For early-stage MPN, the sensitivity and speciﬁcity of the combination were 93.5% and 58.0%, respectively. For advanced-stage MPN, the sensitivity and speciﬁcity of the combination were 91.4% and 72.8%, respectively. The combination of the 7-AAB panel with the Mayo model signiﬁcantly improved the detection rate of MPN, but the positive predictive value (PPV) and the specificity were not improved when compared with either the 7-AAB panel alone or the Mayo model alone.CONCLUSION: Our study confirmed the clinical value of the 7-AAB panel for the early detection of lung cancer, and in combination with the Mayo model, could be used to distinguish benign from malignant pulmonary nodules.
Leptospirosis Associated Kawasaki Disease. Differential Diagnosis or Disease Association? Case Report and Review of The Literature.
Authors: Nashawi Mohammed , Reichert Friedrich , Blankenburg Friederike , Heinkele Anita , Stirnkorb Christian , Noll Felix , Timmermann Kirsten , Hospach Toni
Published: September 2020

Background: Kawasaki disease (KD) is a systemic vasculitis which affects medium-sized arteries. Although diagnostic and classification criteria exist, differentiation from other diseases can be difficult.Case Presentation: We present a 3-year old patient with a diagnosis of complete KD with positivity for urine-PCR on leptospirosis. In our patient conjunctivitis, rash, fever, cervical lymphadenopathy, palmar swelling, exanthema were seen, indicating all criteria for complete KD. After 2 weeks periungual desquamation developed. Besides this patient two further cases were retrieved form the literature with similar clinical courses indicating leptospirosis associated KD.Conclusion: These cases indicate that leptospirosis may not only mimic but also be associated with KD shown by specific findings like desquamation of fingers, toes and oropharyngeal mucous membrane changes. To distinguish between KD, leptospirosis and leptospirosis associated KD a proper history taking including travel history and contact to animals is fundamental as well as thorough clinical and cardiac examinations in the course of the disease. While diagnostic procedures and observation might take time, treatment of acute KD should not be delayed.
Intraspinal Epidural Hematoma Caused By Acupuncture Mimicking An Intraspinal Synovial Cyst: A Case Report 
Authors: Qiu RuiXin , zhou Wei , Yu HaoTao , Zhong ZhiHong , Chen Guoquan , Zhang Ping
Published: September 2020

Background Intraspinal hematoma is a rare complication of acupuncture. A few cases of subdural hematoma or epidural hematoma have been reported, with most of them in a fusiform shape, making the hematomas easy to identify on magnetic resonance imaging (MRI) scans. Case presentation A 49-year-old man presented with back pain that radiated into his lower limb that had appeared during acupuncture of his back. After admission, MRI was performed and indicated an L5/S1 intraspinal mass that had an oval shape, resembling an intraspinal cyst. The patient underwent surgery to remove the mass, which was confirmed to be a hematoma. Conclusion Intraspinal hematomas appear with various intensity signals and shapes on MRI, making its differential diagnosis difficult. A carefully medical history review (to determine if the pain derives from a puncture-type treatment or an injury) and surgical exploration may be helpful for identifying this condition.
Academic Anxiety and Self-handicapping Among Medical Students During the COVID-19 Pandemic: A Moderated Mediation Model
Authors: Jia Jun , Jiang Qin , Lin Xian Hao
Published: September 2020

Background: The outbreak of 2019 coronavirus disease (COVID-19) could increase the risk of academic anxiety among medical students. Research has revealed that academic anxiety was a risk factor for self-handicapping, however, little is known about the underlying mechanisms that may mediate or moderate this association. This study examined the mediating role of procrastination and moderating role of hardiness in the association between academic anxiety and self-handicapping during the COVID-19 pandemic.Methods: This study measured academic anxiety, self-handicapping, procrastination and hardiness in a sample of 320 Chinese medical students, and explored the relationship between variables.Results: Results showed that academic anxiety was positively correlated with procrastination and self-handicapping, and negatively correctly with hardiness; procrastination was positively correlated with self-handicapping, and negatively correctly with hardiness; hardiness was negatively correctly with self-handicapping. Furthermore, procrastination partially mediated the relationship between academic anxiety and self-handicapping, and both the effects academic anxiety on self-handicapping and the mediating effect of procrastination were moderated by hardiness. The direct effect was stronger for medical students with lower hardiness, and the indirect effect was potent for medical students with both levels of hardiness.Conclusion: During the COVID-19 outbreak, the effect of academic anxiety on self-handicapping of medical students was affected by procrastination and hardiness. These findings suggest that we need to pay attention to the academic anxiety and procrastination of medical students during the COVID-19 pandemic, and we can intervene in self-handicapping by cultivating hardiness in the future.