bluuebunny/crossref_metadata_2025 huggingface dataset:
IL-17A in the treatment of nail psoriasis
Authors: Olisova Olga Yu. , Nikuradze Victoria O. , Koroleva Maria A.
Published: March 2022

BACKGROUND: Psoriasis is an inflammatory skin disease that significantly worsens the quality of the patients life. With vulgar psoriasis, the most common form of the disease, nail damage is observed in more than 50% of cases.
AIMS: To evaluate the efficacy and tolerability of secukinumab in the treatment of nail psoriasis (psoriatic onychodystrophy) in real clinical practice.
MATERIALS AND METHODS: The study was carried out on the basis of the Clinic for Skin and Venereal Diseases. V.A. Rakhmanov Sechenov University. The participants were 12 patients diagnosed with psoriasis, aged 29 to 60 years. All patients were diagnosed with a severe degree, 2 (16.7%) patients ― psoriatic erythroderma, 10 (83.3%) ― psoriasis vulgaris, all studied patients had nail plate lesions. All patients were treated with a genetically engineered biological drug ― an IL-17A inhibitor secukinumab (Cosentix), 300 mg subcutaneously once a week (5 injections), followed by a maintenance dose of 300 mg once a month. The course of therapy was 20 weeks (9 injections). Assessment of the severity of nail psoriasis and the effectiveness of therapy was carried out using indices: NAPSI (index of the degree of damage to the nail plates), DLQI (dermatological index of quality of life), which were studied in dynamics before treatment and after 20 weeks of treatment.
RESULTS: The NAPSI index was 25.33.4 points before treatment, and at week 20 it decreased to 2.20.7 points. These results demonstrate a regression of clinical manifestations by more than 80% from the initial state of the nails. When assessing the dermatological index of quality of life (DLQI), it was found that in the study group of patients before the start of treatment, it was 27.42.1 points, which reflected a strong negative effect of psoriasis on the quality of life of patients. After treatment, this indicator was 3.10.5 points among all patients. No patient experienced any side effects from the therapy.
CONCLUSIONS: Secukinumab is a highly effective and safe drug for the treatment of nail psoriasis in patients with vulgar psoriasis and psoriatic erythroderma and contributes to improve the quality of the patients life.
Minimally invasive combined technique of thread implantation, including the use of lifting threads from polydioxanone and a copolymer of polylactic acid and polycaprolactone and reinforcing threads from 100% polylactic acid
Authors: Gribanov Ivan I.
Published: March 2022

Modern scientific studies demonstrate a direct relationship between a decrease in the quantitative ratio of type I/III collagen in tissues and the severity of age-related changes, the formation of a deformative type of aging and the early development of ptosis of the lower third of the face able to compensate for the reduced ratio of type I/III collagen. In addition, the specificity of the threads used to perform lifting technologies provides an increase in collagen, predominantly of type III, and a relatively small number of them and only a certain lifting route are used. Currently, the clinical efficacy of 100% polylactic acid threads has been proven, which are able to stimulate the synthesis of type I collagen. Thus, the combination of lifting and reinforcing techniques in one procedure is expedient and relevant.
In order to achieve aesthetic and lifting results of thread techniques, as well as to increase the intensity of microcirculation, oxygenation and stimulation of collagenogenesis (including type I), we have developed a method of minimally invasive combined technique of thread implantation, including the use of lifting threads made of polydioxanone and polylactic acid copolymer and polycaprolactone and 100% polylactic acid reinforcing threads.
The minimally invasive technology provides prolongation of the lifting effect; creates the effect of volumization of facial tissues and the supporting dynamic framework in conditions of tissue displacement, and also improves the quality of skin structures by stimulating trophic and oxygenation of tissues, strengthening the collagen framework, increasing the ratio of type I/III collagen, enhancing the production of its own hyaluronic acid and extracellular matrix components.
#Plandemi Enfodemisinin Anatomisi: Covıd-19 Pandemisi Döneminde Yanlış Bilginin Yayılımı Üzerine Bir Vaka Analizi
Authors: POLAT Burak , SÜTCÜ Cem
Published: March 2022

Küreselleşen dünyanın ulaşım ağlarıyla COVID-19 pandemisinin yayıldığı gibi sosyal medyanın kullanıcı ağlarıyla enfodemi küresel çapta yayılmaktadır. Sosyal medyanın kitle ve kişilerarası iletişimi iç içe geçiren yapısı ile gelen yayılım potansiyeli yararlı enformasyonun dağıtımını sağladığı gibi bilgi kirliliğinin dağıtımına da sebebiyet verebilmektedir. Bilgi kirliliği, kullanıcılar arasındaki etkileşimin yoğunlaşması ile kitlesel bir hal alarak enfodemiye neden olabilmektedir. Dünya Sağlık Örgütü, bilgi kirliliğine yol açarak insanların virüse ve aşıya karşı tutumunu yanlış yönlendirdiği için enfodemiyi insan sağlığı açısından pandemi kadar küresel çapta mücadele edilmesi gereken bir sorun olarak görmektedir. “Plandemic: The Hidden Agenda Behind COVID-19” (Plandemi: COVID-19’un Ardındaki Gizli Amaç) başlıklı video 4 Mayıs 2020 tarihinde Youtube ve Facebook gibi sosyal medya platformlarında yayınlandıktan sonra hızla yayılarak enfodeminin somut vakalarından biri olmuştur. Video yayında kaldığı iki gün içerisinde izleyenlerin paylaşımları ile hızla yayılarak iki milyona yakın izlenme sayısına ulaşmıştır. Komplo teorilerine yatkın gruplarca dillendirilen COVID-19 iddialarını paketleyerek kitleleri kendine has sihirli çemberine çekmiştir. Video çok kısa sürede yayımdan kaldırılmış olmasına rağmen içerdiği yanlış bilgiler sosyal medyadaki etkileşimler aracılığıyla küresel çapta dolaşımda kalmıştır. Bu araştırmada Plandemic videosunun Türkiye’deki yansımaları Twitter’da #Plandemi etiketi üzerinden kullanıcıların ürettiği içerikler ile tespit edilmiştir. Araştırmanın temel amacı sosyal medyada yanlış enformasyonun nasıl yayıldığını örneklendirerek incelemektir. Vaka analizi olarak yapılandırılan araştırma kapsamında Twitter’da #Plandemi etiketi ile yapılan paylaşımlara hem ağ analizi hem de içerik analizi uygulanmıştır. Ağ analizi sonucunda kullanıcılar arası etkileşimde ve mesaj üretiminde bir güç yasası dağılımı tespit edilmiştir. İçerik analizi sonucunda ise Plandemic videosuyla özellikle sağlık sistemine duyulan güvensizlik temasında içeriksel örtüşme yaşandığı belirlenmiştir. Çalışma bu yönüyle enfodeminin küresel akışkanlığınınbir örneğini temsil ederken bir yönüyle de COVID-19 bağlamında dezenformasyonun ülkemizde nasıl yayılmakta olduğunu da betimlemektedir.
Therapeutics role of spirulina platensis in disease prevention and treatment
Authors: Yamgar Priyanka V. , Dhamak Vikrant M.
Published: March 2022

Spirulina are multicellular and filamentous blue-green microalgae belonging to two separate genera Spirulina and Arthrospiraand consists of about 15 species. Of these, Arthrospira platensis is the most common and widely available spirulina and most of the published research and public health decision refers to this specific species. It grows in water, can be harvested and processed easily and has significantly high macro- and micronutrient contents. In many countries of Africa, it is used as human food as an important source of protein and is collected from natural water, dried and eaten. It has gained popularity in the human health food industry and in many countries of Asia it is used as protein supplement and as human health food. Spirulina has been used as a complementary dietary ingredient of feed for poultry and increasingly as a protein and vitamin supplement to aqua feeds.

Spirulina can play an important role in human and animal nutrition, environmental protection through waste water recycling and energy conservation. Spirulina is free floating filamentous microalgae growing in alkaline water bodies The present review was focused on the various characteristics of Spirulina platensisSpirulina is rich in proteins (60-70%), vitamins and minerals used as protein supplement in diets of undernourished poor children in developing countries. One gram of Spirulina protein is equivalent to one kilogram of assorted vegetables. The amino acid composition of Spirulina protein ranks among the best in the plant world, more than that of soya bean. The mass cultivation of Spirulina is achieved both in fresh water and waste water. Spirulina grown in clean waters and under strictly controlled conditions could be used for human nutrition. The micro algae gown in waste water is used as animal feed and provide a source of the fine chemicals and fuels. The waste water system is highly applicable in populated countries like India where wastes are generated in high quantities and pose environmental problem.
Type- II delayed hypersensitivity reaction by processed elephant foot yam (Amorphophallus paeoniifolius)
Authors: Bano Gulnaz , Sharma Abhishek
Published: March 2022

All types of food and food products carry potential of allergies in human. The property of allergic tendency is being carried through generations to generation in their genomic sequence. The allogenic behaviour of body towards all types of nutraceuticals and ingredients raises huge concern among dermatologist to manage patient. We here have reported a very rare adverse event following ingestion of common staple food of elephant foot yam. However, we suggest that all types of tuberous roots and vegetables should undergo pre-treatment/washing before its consumption for the removal of toxic chemicals and impurities.
Dilemma in low-grade glioma surgery: Review of litreture and when to operate
Authors: Sharma Sanjay , Jain Ritika
Published: March 2022

Diffuse low-grade gliomas (LGG) are tumours of the glial tissue, which are generally slow-growing, but have the potential to undergo anaplastic progression into more aggressive tumours. Diffuse low-grade gliomas (LGG) represent a heterogeneous group of primary brain tumour arising from supporting glial cells. The role of surgery in the management of human low- gliomas has been controversial. The current adjuvant therapies have facilitated treatment of patients, and have rendered neurosurgical removal without morbidity or mortality more commonplace than ever before. Here, we investigated the role of neurosurgery in the management of adults with low-grade gliomas. The management of low- grade glioma is one of the most controversial areas in clinical neuro-oncology. The concept of management of low-grade gliomas is not unitary but much more a composite of different challenges depending on the clinical presentation, signs, neuroradiology, perspectives of neurologists, the opinion of the neurosurgeon, and perhaps most importantly, the aspirations of the patient. It is true therefore that in many patients there will be a dilemma about what is considered optimal management since there is no good evidence base to underpin any single management. Even though there is substantial evidence which claims that surgery have a role to play in extending patient survival.
Recent updates on Levetiracetam
Authors: Panchal Gajanan , Uppal Salil , Uppal Shikhil
Published: March 2022

To review recent clinical evidence available for levetiracetam in the treatment of various types of epileptic seizures.

A literature search was conducted to identify clinical studies conducted after 2015 with Levetiracetam.

In patients with focal epilepsy, Levetiracetam was found to be as effective as Carbamazepine, Clobazam, and Valproic acid but with better tolerability than Carbamazepine. Levetiracetam could be used as monotherapy in the treatment of new-onset focal epilepsy. It probably has a neuroprotective benefit, particularly important in neonates and children. The safety and tolerability of Levetiracetam are more apparent during pregnancy. Thus, the adverse event profile is largely in favor of Levetiracetam in comparison to standard older AEDs. Meta-analysis has confirmed that Levetiracetam is significantly better in terms of withdrawal rates compared to the older AEDs, hence may be considered as the first line in new-onset focal epilepsy in adults and the elderly. Levetiracetam may be a better option as an add-on treatment in children with partial seizures, due to its favorable efficacy and insignificant toxicity than Oxcarbazepine and Topiramate. Recent evidence suggests that Levetiracetam could be a potential first-choice, second-line AED for Benzodiazepine resistance status epilepticus with efficacy comparable to established older AEDs. It improves the quality of life due to higher rates of seizure freedom and favorable tolerability profile.

Levetiracetam has the potential for being a first-line AED and has also proven to be a better adjunctive considering the recent efficacy and safety outcomes.
Cross sectional descriptive study of clinical and radiological profile of patients presenting with recurrent ischemic stroke in a tertiary care centre of South India
Authors: Awati Akash M
Published: March 2022

Even with recent advances in the management of ischemic stroke, incidence of recurrence is quite frequent. Identification of risk factors is of prime importance especially during the first episode of ischemic stroke. Imaging in stroke has pivotal role to play in understanding the stroke and also the recurrence risk. Hence we present a study about clinical and radiological profile of recurrent ischemic stroke patients.

The study was conducted for a period of five consecutive years with a sample size of 100 patients. It is a cross sectional descriptive study where in data was collected and analysed among various variables necessary. Patients with recurrent ischemic stroke were examined and investigated. Continuous variable is expressed as mean +SD or median (Range) if non- normally distributed. Categorical data is expressed in proportions.

Recurrence of the ischemic stroke was commonly seen in the patients with uncontrolled blood pressure, hyperglycemia, dyslipidemia, ischemic heart disease and patients with large artery atherosclerosis. Incidence was higher among male patients, patients above 60 years of age and stroke involving MCA and ACA territories.

Identification of the risk factors responsible for the recurrence at the first episode of ischemic stroke and appropriate management are of prime importance. Apart from clinical and biochemical parameters, considering the radiological parameters like extent of stenosis and appropriate dosing and choice of medication also is of utmost importance in preventing the recurrence of stroke.
Subthalamic nucleus projection by SVM based MER Data via deep brain stimulation: A study of spike uncovering
Authors: Raju V Rama
Published: March 2022

This study was conducted at a medical university tertiary care hospital and research center of dedicated Parkinson and movement disorders unit in Hyderabad (South India) with a purpose to optimize projection of STN by applying M.E.R patterns analytically. 52 locally anesthetized Parkinson`s (diseased subjects/patients) underwent bilateral S.T.N-D.B.S. Concurrent M.E.R signal recording was done in a Ben’s-gun pattern setup with a 5core-pentode (5microelectrodes were set in an array scenario). Using spikes and circumstantial (or contextual) background-activity dissimilar parameters plus their phantom estimates in various-frequency-bands which include low-frequency(2Hz–7Hz), :Hz–12Hz, (sub-divided as low-) and superior :21Hz–30Hz and :31Hz-49Hz were computed. The ideal electrode implantation through better clinical-effect/dyskinesia ratio given to the peak spike-rate(S.R) in 86% of the implant. The amplitude mean-background activity in low-chucked frequency-range(FR) was analogous to right depth in 86% and right-hemisphere position in 95% of the implantation.
A rare cause of acute onset central hypersomnia
Authors: Madhavi Karri , Ramasamy Balakrishnan , Perumal Santhosh , Kannan Karthik Thamarai
Published: March 2022

Tuberculosis of the nervous system constitutes about 10% of total cases and is more common in developing countries like India. Varied clinical presentations, ranging from meningoencephalitis, tuberculoma, multiple cranial palsies to myelo-radiculitis, are noted. Here we highlight central sleep apnoea as an acute presentation, which is unusual in a neurological setting. Here, we present a 49-year old male, presented with acute onset of excessive daytime sleepiness for two weeks. Clinically he had no focal deficits. MRI brain plain and contrast showed multiple conglomerate ring-enhancing lesions with vasculitic infarcts consistent with tuberculosis. CSF analysis was normal apart from slightly elevated protein. He was initiated on steroids and anti-tuberculous therapy. Hypersomnia as an acute and solitary neurological presentation secondary to subacute infections is a rarity. Apart from vascular insults, infections like tuberculosis needed to be considered as one of the differentials. Early evaluation helps in prevention of associated complications and improve the quality of life.
An attempt to evaluate some personality characteristics of Wrocław high school graduates of different pubescence age
Authors: Kolasa Ewa , Umławska Wioleta , Olszewska Ewa
Published: March 2022

An attempt was made to establish the correlation between the time of reaching sexual maturity and the level of psychical development. The material consisted of data obtained from schoolgirls of final classes of 6 secondary schools. In a questionnaire, the girls provided retrospective data concerning the age of menarche, and replied to questions being the basis for sexual maturity evaluation.
A report on the occurrence of accessory triradii in the subdigital area, and carpal triradii on the palm in Polish and Czech populations
Authors: Gąsiorowski Adam , Hajn Václav
Published: March 2022

The study analyses the occurrence of accessory triradii and carpal triradii on human palms in two populations. Accessory triradii were observed in Polish and Czech populations very rarely (triradius d’ was most frequent). The occurrence of the abortive main line C(Y) was observed more often in the Polish population and it was a statistically significant difference. A very high symmetry was stated between the occurrence of forms C(Y) and c(X) on right and left palms. A higher frequency of occurrence was stated in the case of carpal triradius t in the Polish population and of triradius t’ in the Czech population. However, the differences are not statistically significant.
Developing the imagination of primary school students through media technologies
Authors: Elmira Uaidullakyzy , Rysbayeva Galiya , Aigul Baitursynova , Zhetpisbayeva Gulzhan O. , Medeu Alimbayev , Saulesh Tileuova
Published: March 2022

Abstract

 

In this study, it is aimed to develop the imagination of primary school students with media technologies and to design it. The research was carried out in the fall semester of 2021–2022. The study with the participation of 346 primary school students was conducted in a screening model. In the study, 4 weeks of training for creating ideas with media technologies were given to primary school students online. In the study, the media technologies measurement tool developed by the researchers was used to collect data. The data collection tool used in the study was reached and collected with the help of their families using an online method. The analysis of the data was carried out using the SPSS programme; frequency analysis was carried out using the t-test; and the results obtained were added to the study accompanied by tables. As a result of the research, it was concluded that primary school students use media technologies closely and that their imagination powers are strengthened by developing their intelligence with these technologies.

 

Keywords: Primary school students, media technologies, distance education, imagination;
Technology for teaching regional economic relationships based on the updated content of education
Authors: Seraliyev Asset , Kulyash Kaimuldinova , Duman Aliaskarov , Atasoy Emin , Yerlan Nurkeyev , Baktybekov Mukhtar
Published: March 2022

The aim of this study is to determine the technology of teaching regional economic relationships based on the updated educational content to university students and to determine it. The research was conducted in the fall semester of 2021–2022; the study with the participation of 274 university students was conducted in a screening model. In the study, 4 weeks of updated education was provided to university students. In order to collect data, the ‘Updated Education and Teaching Technologies’ measurement tool, developed by the researchers, was used in the study. The scale used in the research was delivered and collected by the online method to university students. The analysis of the data was carried out using the SPSS programme; frequency analysis was carried out using the t-test, and the results obtained were added to the study accompanied by tables.  As a result of the research, it was concluded that the teaching technologies of university students were learned and their updated educational status was good and the values were high.

 

Keywords: Updated Education, Distance Education, Teaching technologies, University Students;
An assessment of the transient effect on helicopter main rotor stability and power demand
Authors: Raczyński Radosław , Siadkowska Ksenia , Ścisłowski Karol , Wendeker Mirosław
Published: March 2022

The researched object os a helicopter main rotor with blades of variable geometric twist characteristics. Variable torsion refers to systems of actuators made of shape memory alloys. The presented numerical analyses allow for evaluating both the dynamics of the rotor in transient states, i.e. in the zone between the static phase and the full activation phase and the impact of the change on the pulsation of the amplitude of the necessary power generated by the rotor corresponding the flight state, and thus covering the demand by the disposable power generated by the engine. This study follows a methodology of numerical analyses based on Multi Body Dynamics and the Finite Element Method and uses fluid mechanics elements and algorithms to analyze lift generation, compiled in a single computational environment referring to the same period of time.
Nrf2 Signaling in Viral Infections
Authors: ROS Editorial Office
Published: March 2022

Nrf2 is a central regulator of cellular antioxidant and other cytoprotective genes. Several recent studies revealed a novel role for Nrf2 signaling in protecting against viral infections, including COVID-19. The findings from these studies pointed to a feasibility for treating viral infections, including COVID-19, via pharmacological activation of the Nrf2 signaling pathway.
(First online: March 3, 2022)
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ANALISIS TINGKAT PENGETAHUAN DAN SIKAP TENAGA KEFARMASIAN DALAM MENCEGAH OBAT RUSAK DAN KADARLUARSA DI RSUD TORA BELO
Authors: Ambianti Nurul , Tandah Muhamad Rinaldhi , Diana Khusnul , Balqis Ratu
Published: March 2022

Abstrak

Obat rusak dan kadaluarsa merupakan salah satu masalah yang dapat mencerminkan ketidaktepatan dan kurang baiknya manajemen pengelolaan obat di sebuah Instalasi Farmasi Rumah Sakit (IFRS). Penelitian ini dilakukan untuk mengetahui tingkat pengetahuan dan sikap tenaga kefarmasian dalam mencegah obat rusak dan kadaluarsa di Rumah Sakit Umum Daerah (RSUD) Tora Belo. Jenis penelitian ini adalah penelitian non-eksperimental dengan pengambilan data secara cross sectional. Data yang digunakan adalah data primer yang diperoleh dari hasil kuesioner yang telah diisi oleh tenaga kefarmasian di RSUD Tora Belo. Analisis yang digunakan pada penelitian ini adalah analisis korelasi menggunakan uji Spearman-Rho, untuk mengetahui hubungan tingkat pengetahuan dan sikap tenaga kefarmasian dalam mencegah obat rusak dan kadaluarsa. Jumlah sampel adalah 33 orang yang diambil secara total sampling. Waktu pengambilan data penelitian selama bulan Mei-Oktober 2020. Dari hasil penelitian dapat diperoleh pengetahuan tenaga kefarmasian dalam mencegah obat rusak dan kadaluarsa dikategorikan cukup yaitu sebanyak 17 orang (71,1%), sikap tenaga kefarmasian dalam mencegah obat rusak dan kadaluarsa dikategorikan sangat kuat yaitu sebanyak 18 orang (85,78%), serta hasil analisis korelasi tingkat pengetahuan dan sikap tenaga kefarmasian dalam mencegah obat rusak dan kadaluarsa diperoleh nilai signifikansi sebesar 0,021, sehingga dapat disimpulkan bahwa terdapat hubungan antara tingkat pengetahuan dan sikap tenaga kefarmasian dalam mencegah obat rusak dan kadaluarsa di RSUD Tora Belo.
Gambaran Gambaran Pelayanan Swamedikasi Oleh Apoteker Di Kota Palu
Authors: Manikam Nurintan Kurnia , Rumi Amelia , Parumpu Firdawati Amir
Published: March 2022

Pelayanan swamedikasi yang baik adalah swamedikasi yang dilakukan oleh tenaga ahli obat yaitu apoteker untuk mengoptimalkan penggunaan obat dan meningkatkan kesehatan. Pada saat yang bersamaan, apoteker juga diharapkan dapat memberikan konsultasi kepada pasien dan memantau setiap masalah yang mungkin terjadi selama penggunaan obat, yang disebut dengan masalah terkait obat (Medication error). Tujuan penelitian ini adalah untuk mengetahui gambaran pelayanan swamedikasi oleh apoteker di kota palu berdasarkan kategori penggalian informasi, pemilihan obat dan informasi obat. Metode penelitian yang digunakan adalah deskriptif kualitatif bersifat cross sectional dan metode pengambilan sampel adalah Purposive sampling. Kriteria responden yaitu apoteker yang memiliki SIPA aktif dan berpraktek di apotek serta bersedia menandatangani lembar Informed consent. Berdasarkan kriteria tersebut, diperoleh 86 sampel apoteker dalam apotek yang berada di Kota Palu. Instrumen yang digunakan yaitu menggunakan kuesioner dalam bentuk Google Form yang telah dilakukan uji validitas dan uji reliabilitas serta data yang diperolehdievaluasi secara deskriptif. Hasil penelitian menunjukkan bahwa apoteker dalam apotek di kota palu sudah melaksanakan pelayanan swamedikasi untuk penggalian informasi sebesar 83,60%, pemilihan obat sebesar 95,35% dan pemberian informasi obat sebesar 89,66%. Kesimpulan dari penelitian ini yaitu apoteker dalam apotek sudah melaksanakan pelayanan swamedikasi dengan baik sesuai variabel.
Aplikasi Teknik Pengolahan Citra Untuk Deteksi Status Nitrogen Pada Daun Stroberi Menggunakan Support Vector Machine Dan Artificial Neural Network
Authors: Syihab Muhammad Firmansyah
Published: March 2022

Pengolahan citra adalah suatu metode yang digunakan untuk mengolah citra (image) sehingga menghasilkan gambar yang sesuai dengan kebutuhan. Pengolahan citra dilakukan untuk memperbaiki kesalahan data sinyal gambar yang terjadi akibat transmisi dan selama akuisisi sinyal, serta untuk meningkatkan kualitas penampakan gambar agar lebih mudah diinterpretasi oleh sistem penglihatan manusia baik dengan melakukan manipulasi dan juga penganalisisan terhadap gambar. Proses ini berupa manipulasi dan menganalisa citra dengan bantuan perangkat lunak melalui computer. Dalam penelitian ini mencari tingkat akurasi dengan menggunakan MATLAB. Stroberi (Fragaria × Ananassa) yang digunakan sebanyak 160 tanaman yang di bagi menjadi 4 kelas yaitu tanpa nutrisi, nutrisi kurang (EC 1,5 ABmix sebanyak 15ml), nutrisi normal (EC 2,0 ABmix sebanyak 30ml), dan nutrisi berlebih (EC 2,5  ABmix sebanyak 40ml) yang diaplikasikan pada instalasi hidroponik. Tujuan dari penelitian ini, yaitu (1) membuat algoritma pengolahan citra dari SVM (Support Vector Machine) dan ANN (Artificial Neural Network) untuk estimasi nitrogen, dan (2) mengetahui tingkat tingkat akurasi dari perbandingan antara SVM (Support Vector Machine) dan ANN (Artificial Neural Network). Variabel yang di ukur dalam penelitian ini adalah Kandungan nitrogen, Intensitas cahaya, Suhu, Pengambilan citra dengan Camera pocket, dan EC (electronic conductivity) air. Hasil penelitian menunjukkan tingkat akurasi dengan metode SVM (training) sebesar 85,9375% dan (testing) sebesar 83,2461%.Tingkat akurasi dengan metode ANN (training) 1 hidden layer sebesar 86,3393% dan 2 hidden layer sebesar 86,7634% sedangkan ANN (testing) 1 hidden layer sebesar 93,6458% dan 2 hidden layer sebesar 92,7083%, rerata kedua hidden layer yang memiliki tingkat akurasi paling tinggai adalah 1 hidden layer 89,9926%.
ANALISIS KINERJA SISTEM PANCI BERTEKANAN PADA SISTEM KONSENTRATOR SURYA TIPE PARABOLA
Authors: Ropiudin Ropiudin -
Published: March 2022

Energi surya merupakan salah satu sumber energi terbarukan yang potensial untuk memenuhi kebutuhan energi dalam kehidupan. Jumlah energi surya yang sampai ke permukaan bumi yang dikenali sebagai konstan surya menyamai 1.350 W/m2 setiap saat, ditambah dengan letak geografis Indonesia yang berada di garis khatulistiwa menjadikan energi surya sangat potensial untuk dikembangkan sebagai salah satu energi alternatif pengganti energi fosil. Teknologi untuk memanfaatkan tenaga surya yang telah digunakan sejauh ini yaitu teknologi surya photovoltaic maupun teknologi panas surya (Solar-Thermal). Energi panas surya pada umumnya digunakan untuk memasak (kompor surya), dan mengeringkan hasil pertanian. Tujuan dari penelitian ini adalah, (1) Mengetahui suhu optimum yang dihasilkan dari proses termal pada sistem panci bertekanan konsentrator surya tipe parabola, (2) mengetahui tekanan optimum yang dihasilkan dari proses termal yang terjadi pada sistem panci bertekanan konsentrator surya termal tipe parabola, dan (3) mengetahui tingkat efisiensi sistem yang dapat dicapai berdasarkan peristiwa pindah panas yang terjadi pada sistem panci bertekanan konsentrator surya tipe parabola. Penelitian ini berfokus kepada uji kinerja dari sistem panci bertekanan yang merupakan salah satu komponen pada sistem konsentrator surya tipe parabola. Analisis data yang digunakan pada penelitian ini menggunakan analisis data kuantitatif dengan mencari hubungan dua variabel. Mencari hubungan dan membandingkan antara intensitas cahaya matahari yang diterima dengan perubahan suhu pada sistem prototipe panci bertekanan terhadap waktu. Analisis data perpindahan panas yang terjadi pada sistem panci bertekanan terhadap perubahan intensitas radiasi matahari, serta efisiensi yang dapat diraih sistem panci pada kondisi iradiasi terukur. Hasil penelitian menunjukkan bahwa: (1) Suhu optimum yang dapat diraih dari prototipe sistem panci berdasarkan 2 data yang telah dipilih adalah pada bagian dasar-luar panci adalah 224,2 oC, untuk bagian dasar-dalam panci sebesar 202,5 oC, dinding-dalam panci = 131,2 oC, tutup panci = 98,2 oC, dan dinding-luar panci (tertutup glasswool) = 84,7 oC. (2) Prototipe sistem panci bertekanan ini dapat menghasilkan tekanan optimum sebesar 0,15 bar atau setara dengan 15 kPa ketika menggunakan air sebagai fluida kerja, sedangkan ketika memakai minyak belum mampu menghasilkan tekanan. (3) Nilai kalor optimal prototipe sistem yang dihasilkan saat proses termal dari 2 data terbaik adalah pada bagian dasar-luar ke dalam = 192,34 kW, dasar dalam ke fluida = 9,8 kW, fluida ke dinding dalam = 40,16 kW, dan bagian dinding dalam ke luar = 171,09 kW. (4) Efisiensi termal optimum yang dapat dihasilkan oleh prototipe sistem panci bertekanan adalah sebesar 88,97%, pada kondisi radiasi matahari 1120 W/m2.
Challenges of Statin Therapy in Clinical Practice (According to Outpatient Register «PROFILE» Data)
Authors: Martsevich S. Yu. , Lukina Yu. V. , Kutishenko N. P. , Zagrebelnyy A. V. , Tolpygina S. N. , Voronina V. P. , Dmitrieva N. A. , Lerman O. V. , Nekoshnova E. S. , Budaeva I. V. , Blagodatskikh S. V. , Aslanova B. B.
Published: March 2022

Aim. To identify the main problems of statin therapy in patients with high and very high cardiovascular (CV) risk in real clinical practice.

Material and methods. The general information of the study was based on data from 2,457 patients who were included in the register before November 30, 2020: 1,250 men (50.9%) and 1,207 (49.1%) women. A more detailed analysis was performed for groups of patients with high          and very high CV risk who had indications for statin treatment at the time of inclusion in the register: out of 2457 patients, 1166 people had very high CV risk, 395 was at high CV risk (a total of 1561 people, the average age of patients was 64.4±11.0 years).

Results. Information on the parameters of the lipidogram – the level of total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) was available in 1918 (78.1%) and 1546 (62.9%) patients, respectively. Of 1561 patients with high and very high CV risk, TC and LDL-C levels were analyzed in 1221 (78.2%) and 956 (61.2%) cases, statistically significantly more often in patients with high CV risk (p<0.05). Statins were recommended only to 823 (52.7%) patients with high and very high CV risk. Patients with very high CV risk received such appointments 4 times more often than patients with high CV risk: odds ratio (OR) 4.2; 95% confidence interval (CI) 3.2-5.3 (p<0.001). Doctors preferred atorvastatin in prescriptions (n=456, 55.4%), rosuvastatin (n=244, 29.7%) and simvastatin (n=121, 14.7%) were in second and third places. The target level of LDLC was 2 times more often achieved in patients with high CVR, compared with patients with very high CV risk: OR = 2.0, 95% CI 1.4-3.0 (p<0.001).

Conclusion. The main problems of statin treatment in real clinical practice remain the non-assignment of these drugs to patients who have indications for such therapy and the failure to achieve the target levels of lipidogram indicators, which may probably be due to the clinical inertia of doctors regarding titration of statin doses, and in some cases caused by the choice of drugs that are not the most effective in reducing LDL cholesterol. Patients with very high CV risk are 4 times more likely to receive a recommendation to take statins compared to patients with high CV risk, but the target level of LDL cholesterol is reached in them 2 times less often.
Prognostic Significance of the Integral Index of the Alcohol Situation in Assessing Regional Differences in Mortality from Cardiovascular Diseases in the Russian Federation
Authors: Gornyi B. E. , Kalinina A. M. , Drapkina O. M.
Published: March 2022

Aim. To evaluate the stability of the integral index of the alcohol situation in the regions of the Russian and its prognostic significance regarding adult mortality from diseases of the circulatory system.

Material and methods. The dynamics of standardized mortality rate for cardiovascular diseases (CVD) and TM in 2012 and 2018 in regions of Russia with safe and unsafe alcohol situations was analyzed. The average group mortality rate were evaluated, as well as the average rate of dynamics of the indicator reduction for the period from 2012 to 2018.

Results. In 2012, differences in the rates of total mortality, as well as mortality from CSD, IHD, and CVD in regions with different levels of alcohol wellbeing were significant with a significance level of p <0.05. In 2018, intergroup differences in mortality from CSD and IHD were unreliable. Differences in average mortality rates from other causes significantly differed with a significance level of p <0.05. Total mortality and mortality from CVD, including individual forms, decreased in all regions, regardless of the level of alcohol well-being. The average rate of decline in mortality in the group of regions with an unfavorable situation was lower than the same indicator in regions with a favorable situation, with the exception of mortality from CVD. The most pronounced were differences between regions in the rate of decline in mortality from MI (p <0.05). For the remaining causes of death, the differences were not significant.

Conclusion. The hypothesis of a significant contribution of the alcohol factor to cardiovascular mortality is confirmed. In the groups of regions that differ in the integral index of the alcohol situation, significant differences were noted in the indicators of both total mortality and mortality from the main groups of cardiovascular diseases. These differences persist over time, which confirms the hypothesis that the proposed integral indicator can be used for a long-term forecast of the influence of the alcohol situation on public indicators.
Aging Challenges. Perceived Age – a New Predictor of Longevity?
Authors: Shalnova S. A. , Imaeva N. A. , Imaeva A. E. , Kapustina A. V.
Published: March 2022

The ageing process is accompanied by the manifestation of many characteristics, so-called biomarkers, which can be quantified and used to assess a patient's health status. One of these signs is the progressive decline of a human's facial look, which is described by the concept of 'perceived age'. Facial aging is the most important parameter of perceived age. However, over the years, researchers have identified risk factors that affect the facial skin, including smoking, systematic consumption of alcoholic beverages, overweight or underweight, environmental conditions, and psychosocial determinants. The influence of psychological state on the appearance and life prognosis is shown. The authors presented data from the international literature on the study of perceived age. The frontiers of using perceived age as a biomarker of aging were Danish scientists who developed the main methodological approaches to determine this indicator. One such methodology used in population studies has been the clinical technique of assessing perceived age through photography. The review presents this methodology in detail, with its advantages and modifications. The authors conclude that the measurement of an individual's perceived age can serve not only as a prognostic indicator,  but also over time can become a   useful marker of the effectiveness of various treatments. Until now perceived age has hardly been studied in population studies, the authors presented data from the works of V.A.  Labunskaya, G.V.  Serikov,  T.A.  Shkurko who develop the direction related to psychology of perceived age  and in their studies use social-psychological approaches of appearance assessment.
Cerebrovascular Accident in a Patient with Polycythemia: a Case Report
Authors: Drapkina O. M. , Almazova I. I. , Smirnova A. V. , Berns S. A. , Shepel R. N.
Published: March 2022

Polycythemia vera is not only a clonal disease that causes hematopoietic stem cells, but also a pathology that often leads to thrombotic complications. Thrombosis can have different localization and is clinically manifested by stroke, myocardial infarction, deep vein thrombosis of the lower extremities, pulmonary embolism, thrombosis of the veins of internal organs and other conditions. One of the most formidable thrombotic complications is acute cerebrovascular accident. The heterogeneity of the possible causes of acute cerebrovascular accident requires a careful approach to differential diagnosis for timely diagnosis and individual, pathogenetically grounded selection of means of long-term antithrombotic therapy. The presented clinical case of the development of cerebrovascular accident in a patient with polycythemia vera demonstrates the importance of an informal approach to diagnosis, as well as interdisciplinary interaction for finding the true cause of the development of acute cerebrovascular accident and the appointment of pathogenetically based treatment, aimed, among other things, at the prevention of repeated episodes of acute cerebrovascular accident and others. thrombotic complications.
Cardioprotective Strategies for Doxorubicin-induced Cardiotoxicity: Present and Future
Authors: Chaulin A. M. , Duplyakov D. V.
Published: March 2022

The improvement of drugs and protocols of chemotherapeutic treatment has led to improved outcomes and survival in patients with cancer. But along with this, at first glance a positive point, there was another interdisciplinary problem, which is the need for early detection and treatment of developing cardiotoxicity when taking chemotherapy drugs. The study of cardioprotective strategies has recently become increasingly relevant, due to the fact that many patients who have successfully undergone treatment for cancer have a high risk of developing or are at high risk of death from cardiovascular diseases. One of the main drugs for the treatment of a number of oncological diseases is an anthracycline – type antibiotic-doxorubicin. This review briefly examines the risk factors and pathophysiological mechanisms underlying anthracycline cardiotoxicity. The current possibilities of cardioprotection of anthracycline cardiotoxicity are considered in detail, and some promising targets and drugs for improving cardioprotective strategies are discussed.
Preventive Screening of Young People from the Perspective of Vascular Aging Phenotypes: the Role of Body Weight
Authors: Evsevyeva M. Y. , Eremin M. V. , Rostovtseva M. V. , Sergeeva O. V. , Rusidi A. V. , Kudryavtseva V. D. , Shchetinin E. V.
Published: March 2022

Aim. To study the cardiovascular stiffness index CAVI in relation to main risk factors (RF) in young people from the point of their vascular aging phenotype and gender.

Material and methods. 264 young people (93 boys and 171 girls) at age of 18 to 25 years were examined. Vascular screening was performed with evaluating of CAVI. All subjects were divided into tertile groups for this indicator, taking into account gender. Such interval analysis of gender- and age- homogeneous sample allows to identify carriers of the phenotypes of premature (upper CAVI-tercile), normal (middle CAVI-tercile), and favorable or healthy (low CAVI-tercile) vascular aging. The first of them is also called EVA (early vascular aging) syndrome. In these groups, the incidence of carriers of insufficient, normal body mass (BM) and overweight were estimated. In three groups formed by BM indicator, the parameters of CAVI, hemodynamic and metabolic status in response to changes in BM were determined.

Results. Among of the presented RF, the correlation was significant for CAVI with a weight -0.428 (p<0.001) for R-CAVI, -0.453 (p<0.001) for L- CAVI, and even more significant with the BM index - at the level of -0.410 (p<0.001) for R-CAVI and -0.462 (p<0.001) for L-CAVI. This connection is found in boys. Among boys and girls with excessive BM, the most favorable vascular aging phenotype is observed 2.7 and 2.2 times more often than the EVA syndrome. In contrast, among girls with insufficient BM, a favorable vascular phenotype is detected almost twice rarely as compared with EVA syndrome. In similar group of boys, a healthy vascular phenotype is not observed at all. Among normal-weight boys and girls, the occurrence of the two extreme vascular phenotypes is almost identical. The arterial rigidity decrease on the background of BM increase occurs despite the сhanges of hemo- dynamic and metabolic indicators. This changes are especially pronounced in girls. The difference between the extreme weight categories in terms of R- CAVI and L-CAVI for boys was 1.4, while for girls it was only 0.3 for R-CAVI and 0.4 for L-CAVI.

Conclusion. When carrying out preventive measures among young people, one should not limit oneself to evaluating only traditional RF. Based on the concept of vascular aging, angiological screening should be more widely implemented. It will allow for more individualized preventive interventions among young people in the future.
Мониторинг и прогноз развития эпидемии COVID-19 в г. Москва: выбор моделей на основе технологии сбалансированной идентификации (2220-2021)
Authors: Соколов Александр , Соколова Любовь
Published: March 2022

Любая математическая модель является отражением знаний об исследуемом объекте. В работе показано, как накопление информации (статистических данных и знаний) о пандемии COVID‑19 приводит к уточнению математических моделей, к расширению области их использования. Построенные в результате модели удовлетворительно описывают динамику заболеваемости COVID-19 в г. Москва. Они могут использоваться для прогноза с горизонтом в несколько месяцев при условии, что в моделируемом объекте не появляются (или проявляются) новые, ранее “незаметные” элементы. Основным внутренним механизмом, определяющим динамику модели, является коллективный иммунитет и заметное повышение заразности вируса во второй половине 2021 года (из-за распространения штамма Дельта). Приводятся результаты использования технологии сбалансированной идентификации для мониторинга пандемии COVID-19:

• модели, соответствующие данным, доступным в различные моменты времени (с марта 2020 по декабрь 2021);

• полученные новые знания – функциональные зависимости, определяющие динамику системы;

• результаты расчетов различных эпидемических показателей (заболеваемость, иммунитет, индексы репродукции и др.)

• различные прогнозы для г. Москва (от 01.12.2020, 15.04.2021, 01.08.2021 и 01.08.2021).

Обсуждаются трудности, возникшие после 01.09.2021, и направления дальнейшего модифицирования модели.