bluuebunny/crossref_metadata_2025 huggingface dataset:
Environmental prediction and innovation
Authors: Uddstrom Michael
Published: December 2023

​Using weather-related hazards research as a starting point, this paper shows how a research effort focused on natural hazards prediction has developed a capability (EcoConnect) that is now demonstrating benefits far beyond its primary focus. In this regard EcoConnect meets one of the generally accepted definitions of innovation: ‘the successful exploitation of creative ideas within an organisation’. EcoConnect is built on the creative capabilities of a multi-disciplinary team of scientists and ICT specialists and has adopted a partnership-based approach to working with potential endusers. In this way scientists and end-users are exposed to each other’s ideas – leading to both more informed research directions, and, among end-users, a better understanding of the strategic (as well as tactical) potential of new science results. It is also noted that while an ‘innovation system’ is only as good as the quality and quantity of research and technology that underpins it, funding that alone is not sufficient. Investors must be willing to sustain the effort (from basic research to end-user engagement – including iterative innovations arising therefrom) over a long period – especially if the innovation is likely to be disruptive to existing technologies/capabilities.
R&D in a small technology-focused business – Puku Ltd
Authors: McElrea Dan
Published: December 2023

​
İzmit Kent Planlaması ve Sulak Alan Bölgesine İlişkin Plan Kararları
Authors: KANIK Duygu
Published: December 2023

Günümüzde dünyanın ve ülkemizin en önemli gündemini oluşturan çevre sorunları çok sayıda araştırma ve çalışmaya konu olmaktadır. Özellikle sanayileşme ve nüfus artışının etkisi ile yaşanan hızlı kentleşme süreçleri yalnızca insanların değil, o bölgede yaşayan diğer canlıların da yaşamını etkileyen önemli bir faktör olarak karşımıza çıkmaktadır. Bu doğrultuda planlama ve uygulama aracı olan kent planları, kentleşme ve nüfus artışı arasındaki dengeyi fizik mekanda, mekanın tüm özellikleri ve değerlerini de dikkate alarak doğru bir kurgu ile kurabilmek için önem taşımaktadır. Ancak planların mekandaki değişimlerin gerisinde kalması ve kentlerin plan öngörülerinden farklı gelişmeler göstermesi sonucu planlar değişime zorlanmış, doğal çevrenin öneminin artması ile de fizik mekana dair alınan eski plan kararları bu alanların koruma süreçleri ile çelişmeye başlamıştır.

Birçok canlı türünün barındığı, biyolojik çeşitliliğin arttırılması ve devamlılığı açısından önem taşıyan sulak alanlar, 1970’li yıllara kadar kentsel gelişimin sınırlı olması nedeni ile yapılaşmaya konu olmaz iken, salgın hastalıklarla mücadele, taşkın kontrolü ya da arazi elde etme amacı ile kurutulmaya çalışılmış; bu tarihten sonra bu alanların korunması için dünyadaki sözleşmelere taraf olunmasına karşın, 1980’lerde kentlerin planlardan bağımsız kontrolsüzce büyümesi, mevzuatın ve yereldeki çalışmaların ancak 1990’lı ve 2000’li yıllarda ortaya konması nedeni ile kurumuş, zarar görmüş ve yok olmaya yüz tutmuştur.

Bu çalışmanın amacı, ülkemizde yoğun sanayileşme ve kentleşmeye konu olan İzmit’te, Dünya kuş göç yolları içerisinde göçmen kuşların göç rotası üzerinde bulunan “İzmit Körfezi Sulak Alanı” planlama geçmişinin ele alınması ve alanın bugünkü durumunu ortaya koyarak gelecekle ilgili önerilerde bulunulmasıdır.

Çalışma, ülkemizde sanayileşmenin doğal kaynakların önüne konulduğunu, süreç içerisinde özel mülkiyete konu edilen alanların kamu eline geçmesi yönündeki sorunların çözümünün koruma alanlarının sınırlarının daraltılması olarak ele alındığını ortaya koymakta ve giderek yitirilme tehlikesinin söz konusu olduğu, yaşamsal öneme sahip sulak alanların sürdürülebilirliğinin sağlanması için neler yapılabileceğini İzmit Körfezi Sulak Alanı özelinde ortaya koyarak, bu konuda somut adımların atılacağı bir ortamı yaratmaya çalışmaktadır.
Systematic Literature Review of Sustainable Finance: Implications for Entrepreneurial Finance through Venture Capitals (VC)
Authors: Mehrabi Rosa
Published: December 2023

The idea of sustainable development as a whole gave rise to the concept of sustainable finance in recent decades. It illustrates how financial markets address the current and upcoming economic, social, and environmental issues. This study reviews the literature on sustainable finance and how it relates to venture capital and entrepreneurial finance research topics. As part of the research process, a Systematic and methodical assessment and analysis of the literature was carried out.  The results present comprehensive summaries of the main themes and frameworks, as well as the opportunities, challenges, strengths, and weaknesses of the fields. It also highlights the interaction between sustainable finance and venture capital in supporting innovation and sustainability in entrepreneurship.  The main paper's contribution is to identify sustainable finance as a process that operates at multiple levels. It indicates that a shift in the financial paradigm from profit maximization to sustainability facilitation is required to attain sustainable development at the level of private financial markets and sustainable entrepreneurship. According to the findings, venture capital funds are major participants in the private financial sector, supporting entrepreneurial startups and playing a key role in sustainable finance by promoting a culture of innovation, resource efficiency, and sustainability among entrepreneurial ventures. The paper cites critical review as the source of these arguments. Finally, through applying this comprehensive critical analysis, several gaps in the existing literature have been identified and discussed.
Liver histopathology of broiler chicken (Gallus domesticus): A veterinary forensic model 48 h postmortem
Authors: Az Zahra Shafiyyah , Harlina Eva , Subangkit Mawar , Wiranti Rahayu Woro , Priosoeryanto Bambang Pontjo
Published: December 2023

Veterinary forensic science has not received adequate attention in Indonesia; therefore, its development needs to increase. This research aimed to study veterinary forensic science through histopathology of broiler chicken livers 48 h after death. Seventy-five broiler chickens aged 7 days were euthanized and divided into 25 groups based on post-euthanasia necropsy (n=3). Chicken cadavers were necropsied every 2 h postmortem, and livers were collected to prepare histopathological sections and stained with haematoxylin-eosin (HE). Liver histopathology evaluation and the results obtained were analysed using ImageJ software version 1.53a. The relationship between histopathological variables and postmortem time was analysed using the Pearson’s method. The results showed that decay began at the 18th h postmortem which was marked by the number of hepatocyte cell nuclei. At the 20th hour, putrefactive bacteria were found, and at the 22nd hour, there was an increase in the distance between the hepatocytes. Based on the Pearson correlation value, the number of hepatocyte cell nuclei, the distance between hepatocytes, and the presence of putrefactive bacteria have a strong to very strong relationship with postmortem time; therefore, these results can be used to determine the time of death (postmortem interval)
Pengaruh Metode Eja Dalam Meningkatkan Kemampuan Membaca Permulaan Pada Siswa Sekolah Dasar
Authors: Kholilah Manna , Sapri Sapri , Rambe Riris Nurkholidah
Published: December 2023

Penelitian ini bertujuan untuk mengetahui Pengaruh Metode Eja dalam Meningkatkan Kemampuan Membaca Permulaan Siswa pada Mata Pelajaran Bahasa Indonesia Kelas 1 SD Negeri 138 Sabajior. Populasi pada penelitian ini yaitu seluruh siswa kelas 1 SD Negeri 138 Sabajior. Sampel diambil dengan teknik probabibility sampling yang terdiri dari 24 siswa pada kelas A sebagai kelas kontrol dan kelas B sebagai kelas eksprimen. Penelitian ini menggunakan penelitian kuantitatif jenis penelitian quasi eksprimental design (eksprimen semu) dengan bentuk penelitian pretest-postest dan instrumen yang digunakan berupa soal pilihan ganda untuk mengetahui hasil belajar. Analisis data hipotesis dilakukan dengan melalui microsoft excel. Berdasarkan hasil perhitungan menggunakan analisis t-test kelompok independen, dengan taraf signifikan 0,05, diperoleh nilai Sig 0,04 dimana 0,04 < 0,05. Hal ini menunjukkan bahwa Metode Eja dapat memberikan pengaruh yang signifikan. Diperoleh rata-rata hasil belajar siswa pada kelas eksprimen dengan penerapan Metode Eja adalah 72,79 dengan selisih antara nilai pretest dan postest sebesar 42,5. Sedangkan rata-rata hasil belajar siswa dengan metode konvensional adalah 72,16 dengan selisih nilai pretest dan postest kelas kontrol sebesar 45,4. Berdasarkan hasil tersebut, dapat disimpulkan bahwa penerapan Metode Eja lebih baik daripada metode konvensional serta terdapat pengaruh yang signifikan terhadap hasil belajar siswa pada pembelajaran Bahasa Indonesia di SD Negeri 138 Sabajior Kec. Panyabungan Barat.
End-to-end Verification of Automated SRS with HyperArc on the TrueBeam Platform
Authors: Santos Matheus Fernando , Delbem Albino Lucas , Pieri Bueno Karen , Santos da Silva Ueslen , Geneci da Costa Calado Jose , Silva Oliveira Roberta , Luana Oliveira Barbosa Jessica , Moreira Alves Luccas , Henrique Roesler Ernesto
Published: December 2023

A Radiocirurgia estereotáxica (SRS) é uma técnica de tratamento extremamente complexa, pois envolve várias etapas e consiste em administrar elevadas doses de radiação em poucas aplicações. Dentre as etapas estão procedimentos de aquisição de imagens, registro de imagens, definição do volume alvo, planejamento do tratamento e cálculo de dose, posicionamento do paciente com sistema de IGRT, bem como a entrega do tratamento no equipamento. O teste de ponta a ponta (E2E) é capaz de nos fornecer a incerteza combinada de todo o processo envolvido em procedimentos complexos, como é a SRS. Este estudo consistiu em simular todo o fluxo de tratamento de um paciente em um simulador antropomórfico, e: (i) analisar a aquisição das imagens e o registro, de maneira qualitativa e quantitativa, (ii) realizar o planejamento de tratamento nesse simulador e (iii) verificar a entrega de dose de radiação por meio da medida de dose absoluta com câmara de ionização e análise da distribuição de dose planar com filme radiocrômico. Os resultados das análises quantitativas dos registros através do TRE e DSC foram consideradas satisfatórias, segundo as tolerâncias do TG-132. Os resultados das medidas com câmara de ionização para determinação da dose absoluta pontual apresentaram variações inferiores a 3% do valor calculado pelo TPS. A análise da distribuição de dose planar com filme radiocrômico mostrou que há concordância entre o perfil de dose calculado pelo TPS e o medido, com taxa de aceitação superior a 98% no critério gama de 3%/1mm. A recomendação para a frequência do teste E2E é pelo menos anual, ou após algum reparo ou substituição de equipamento com potencial impacto na integridade dos dados e a cada atualização de software de registro de imagem ou TPS.
Ser católico em tempos de passagem
Authors: Martins Filho José Reinaldo Felipe
Published: December 2023

O presente artigo se propõe discutir as principais influências para a composição da identidade católica no Brasil atualmente. Recorre, para isso, a categorias desenvolvidas ao longo dos últimos quatro séculos, com particular enfoque para o assentamento das bases do individualismo atual. Discute a reorientação sofrida pelo próprio conceito identidade, saindo de uma acepção linear e estanque e deslocando-se para uma interpretação maleável e dinâmica, em que aspectos antes contrastantes podem ser ora aproximados na composição que os indivíduos sustentam a respeito de si. Chama a atenção para a crise dos vínculos comunitários ensejada por esse novo paradigma autorreferencial e para o que isso pode implicar à dimensão do pertencimento, outrora fundamental para a leitura da identidade católica. Palavras-chave: Identidade católica; Indivíduo; Crise dos vínculos comunitários.

Abstract: This article proposes to discuss the main influences for the composition of Catholic identity in Brazil today. For this, it resorts to categories developed over the last four centuries, with a particular focus on laying the foundations of current individualism. It discusses the reorientation suffered by the identity concept itself, moving away from a linear and watertight meaning and moving towards a malleable and dynamic interpretation, in which previously contrasting aspects can now be approximated in the composition that individuals maintain about themselves. It draws attention to the crisis of community ties brought about by this new self-referential paradigm and to what this may imply for the dimension of belonging, once fundamental for reading Catholic identity.

Keywords: Catholic identity; Individual; Crisis of community bonds.
Development of hands on mathematics module based on journal review to promote student involvement in merdeka curriculum
Authors: Kusumawati Ratih , Hidayati Destia Wahyu , Kurniati Lenny
Published: December 2023

The massive development of technology in education has led to the implementation of digital-based learning. However, the impact of the pandemic and the implementation of online learning by utilizing digital technology has caused problems in the form of learning loss. The Merdeka Curriculum as an effort to resolve this learning loss has actually created new problems, that is, teachers' difficulties in implementing differentiated, fun, and meaningful student-centered learning. More specifically, this difficulty occurs for math teachers who do not have references to various mathematics activities that support meaningful learning. One alternative solution to solve this problem is to have a special module that contains references to various mathematical activities and games. The purpose of this research is to develop a hands-on mathematics module based on journal studies which becomes a teaching module in the manipulative mathematics media course. The research and development model to be implemented is 4D Thiagarajan which consists of 4 stages, these stages are define, design and develop. The dissemination stage was not carried out in this period due to research limitations. The results showed that the developed module met the validity criteria with a score of 2.71, met the practicality criteria with a score of 87% and met the effectiveness criteria with a score of 91,6. It’s concluded that the hands on mathematics module was feasible to use and met the criteria of valid, practical, and effective. The results of the study are expected to be a recommendation for further development research and for teachers in designing mathematics learning.
The mathematical reasoning abilities of students in solving numeracy literacy problems reviewed from reflective-impulsive cognitive style
Authors: Chusnudhin Rehan Muchammad Fadli , Ahshoni Ahmad Farhan , Nafsak Ahmad Arofi , Permana Kelvin Lutfi , Sari Anisa Fatwa
Published: December 2023

Mathematical reasoning is one of the five fundamental mathematical abilities that students need to master. The ability of mathematical reasoning is required by students to solve numeracy literacy problems. One of the factors influencing students' mathematical reasoning abilities is their reflective-impulsive cognitive style. This research aims to describe students' mathematical reasoning abilities in solving numeracy literacy problems in terms of the reflective-impulsive cognitive style. The research adopts a qualitative approach, with 6 students from class 9B at SMP Al Falah Ketintang Surabaya selected using purposive sampling. The research instruments include the MFFT cognitive style test sheet, numeracy literacy test sheet, and an interview guide that has been validated by three validators. Data analysis techniques involve data collection, data condensation, data presentation, and drawing conclusions. Based on the analysis and discussion, it is concluded that the mathematical reasoning abilities of students with a reflective cognitive style, particularly in the indicator of performing mathematical manipulations, are not yet well fulfilled. Similarly, the mathematical reasoning abilities of students with an impulsive cognitive style, especially in the indicator of constructing evidence and providing reasons/evidence for the correctness of the solution, are not yet well fulfilled. The mathematical reasoning abilities of students with both reflective and impulsive cognitive styles in solving numeracy literacy problems are more dominant in the moderate and low categories.
Mathematical logical intelligence of students with high mathematical communication skills in system of linear equations in three variable
Authors: Lanya Harfin , Zahroh Halimatus , Zayyadi Moh , Anjarani Devie Reztia
Published: December 2023

Mathematical logical intelligence greatly influences students' ability to solve mathematical problems, especially the ability to analyze logically in solving mathematical problems. This logical-mathematical intelligence is also closely related and has a positive impact on students' mathematical communication skills, both oral and written mathematical communication abilities. Based on the age development, MA students should be able to use logical thinking skills well. Through  material students are tested and required to understand questions in the form of story questions to be able to solve the problem by first forming a mathematical model and then developing a plan to solve the problem. Thus, students indirectly get a stimulus to hone their reasoning and communication skills well. This study aims to analyze the mathematical logical intelligence of MA students with high mathematical communication skills on System of Linear Equations in Three Variable  at MA Al-Islamiyah I Sumber Batu, Blumbungan, Larangan, Pamekasan. This type of research is qualitative descriptive research. The research instruments used were test questions and interview guidelines. The results showed that students who have high mathematical logical intelligence also have good competence for oral and written communication and are able to classify, compare, perform calculations correctly, reason deductively, make conclusions and check back according to the indicators in mathematical logical intelligence.
Data, Analytics, and Intelligence
Authors: Sun Zhaohao
Published: December 2023

We are living in an age of big data, analytics, and artificial intelligence (AI). After reviewing a dozen different books on big data, data analytics, data science, AI, and business intelligence (BI), there are the current questions: 1) What are the relationships between data, analytics, and intelligence? 2) What are the relationships between big data and big data analytics? 3) What is the relationship between BI and data analytics? This article first discusses the heuristics of the Greek philosopher Plato and French mathematician Descartes and how to reshape the world. Then it addresses the above questions based on a Boolean structure, which destructs big data, data analytics, data science, and AI into data, analytics, and intelligence as the Boolean atoms. Data, analytics, and intelligence are reorganized and reassembled, based on the Boolean structure, to data analytics, analytics intelligence, data intelligence, and data analytics intelligence. The research will analyse each of them after examining the system intelligence. The proposed approach in this research might facilitate the research and development of big data, data analytics, AI, and data science.
Тревожные состояния с позиции теории Н.А. Бернштейна: хронобиологический подход
Authors: Зимина Светлана Валерьевна
Published: December 2023

В работе представлена гипотетическая модель развития и редукции тревожных состояний, основой которых является изменение ритмики различных систем организма - дыхательной, сердечно-сосудистой, пищеварительной и т.д. Данная модель основана на принципах уровневой организации движений человека, разработанных Н.А. Бернштейном. На основе положений данной модели рассмотрена последовательность возникновения и исчезновения различных симптомов, составляющих основу панического приступа. Предлагается рассмотрение связи панического расстройства с депрессивным синдромом с позиции модели уровневой организации движений человека.
Диваза в терапии цереброваскулярной болезни: механизм действия и показания к назначению препарата
Authors: Воробьева Ольга Владимировна , Фатеева Виктория Вячеславовна
Published: December 2023

Диваза, комбинированный препарат c оригинальным механизмом действия, оказывает модифицирующее воздействие на функциональную активность белка S-100 и эндотелиальную NO-синтазу, показан для лечения пациентов с хронической цереброваскулярной болезнью. Приведен обзор экспериментальных и клинических исследований механизмов действия и терапевтической эффективности комбинированного препарата Диваза на различных экспериментальных моделях ишемии головного мозга и нейродегенеративных заболеваний и в клинической практике.
Учение о психопатических конституциях в концепции В.А. Гиляровского
Authors: Пятницкий Николай Юрьевич
Published: December 2023

В статье приведен анализ концепции психопатий в описании В.А. Гиляровского. Рассмотрены два основных источника фор- мирования этого клинического понятия: теория «дегенерации», заимствованная в психиатрии из области зоологии, ботаники и антропологии, и понятие конституции, пришедшее в психиатрию из области общей медицины и биологии. Сопоставляются типология и критерии выделения психопатических личностей в концепциях В.А. Гиляровского и П.Б. Ганнушкина. Представлен анализ расхождений в понимании авторами критериев парциальности/тотальности, выраженности/латентности и различий в требованиях к возрастным границам установки диагноза.
Проблемы определения феномена адинамии и роли адинамических расстройств в структуре эндогенных депрессий
Authors: Гедевани Екатерина Владимировна
Published: December 2023

Феномен адинамии до настоящего времени недостаточно изучен и понят. Не существует единой точки зрения относительно его места в картине депрессивных состояний.Цель - представить обзор данных отечественных и зарубежных авторов XX и XXI вв., занимавшихся проблемой дифференциации аффективных расстройств и определением места адинамических нарушений в структуре депрессии.Результаты. На основании проведенного анализа данных литературы выделены главные направления, объединяющие достаточно противоречивые взгляды исследователей на психопатологические особенности явления адинамии.
Отечественный и зарубежный опыт нейропсихологической оценки высших психических функций при синдроме мягкого когнитивного снижения. Сообщение 2. Зарубежные нейропсихологические методики оценки познавательной сферы при синдроме мягкого когнитивного снижения
Authors: Есейкина Любовь Игоревна , Лукин Алексей Владимирович , Плужников Илья Валерьевич
Published: December 2023

Цель - представить современные зарубежные нейропсихологические методики исследования синдрома мягкого когнитивного снижения (МКС) в позднем возрасте.Результаты. Современные нейропсихологические методики оценки познавательной сферы при МКС разделены в соответствии с процедурой их проведения на традиционные, осуществляемые экспертом-нейропсихологом, и компьютеризированные. Описана процедура их применения, обобщены данные о показателях специфичности/чувствительности конкретного метода.
Применение воксельной морфометрии в уточнении морфологии гиппокампа у пациентов с депрессиями и здоровых добровольцев
Authors: Ананьева Наталия Исаевна , Ежова Руслана Владимировна
Published: December 2023

Цель: методом нейровизуализации изучить структуры головного мозга, в первую очередь гиппокампа, у пациентов с депрессией в сравнении со здоровыми добровольцами.Материал и методы: выполнено МРТ-обследование 148 человек (101 здорового добровольца и 47 пациентов с депрессивным расстройством). Проводилась постпроцессинговая обработка с использованием программной среды FreeSurfer с выполнением воксельной морфометрии структур головного мозга и мануальной постобработки в программе DISPLAY для оценки объемов отдельных субрегионов гиппокампа. Результаты: при сравнении данных воксельной морфометрии у пациентов с депрессией по сравнению с контрольной группой были выявлены статистически значимые различия в объемах правого таламуса ( p ≤ 0,01), правого гиппокампа ( p ≤ 0,05), левых гиппокампа и амигдалы ( p ≤ 0,01) и левого таламуса ( p ≤ 0,01). Кроме того, сегментация отдельных частей гиппокампа обнаружила, что основные различия касаются не столько гиппокампа в целом, сколько отдельных его частей (головок гиппокампов, с большей степенью достоверности справа).
Детская и подростковая психиатрия в изменяющемся мире. 17-я конференция Европейского общества детских и подростковых психиатров (ESCAP), Женева 09–11 июля 2017
Authors: Зверева Наталья Владимировна
Published: December 2023

.
Matematik Öğretmeni Adaylarının Matematiksel İspat Yapma ve Problem Çözme Süreçlerinin Sesli Düşünme Yöntemi ile İncelenmesi
Authors: YEŞİLYURT ÇETİN Aysun , DİKİCİ Ramazan
Published: December 2023

Bu araştırma matematik öğretmeni adaylarının matematiksel ispat yaparken ve problem çözerken zihinsel süreçlerinin nasıl ilerlediğini ve sesli düşünme yöntemine ilişkin görüşlerinin neler olduğunu ortaya çıkarabilmek amacıyla yapılmıştır. Durum çalışması deseninin esas alındığı bu araştırma kapsamında 4 öğretmen adayından düşüncelerini sesli olarak ifade ederek 2 problemi çözmeleri ve 2 cebirsel ispatı yapmaları istenmiştir. Öğretmen adaylarının sesli düşünme süreçleri video kayıt altına alınmıştır. Videolar transkript edilerek elde edilen veriler, betimsel analiz yöntemi ile analiz edilerek yorumlanmıştır. Araştırma sonucunda öğretmen adaylarının teorem ispatının ve problem çözümünün nasıl olacağına yönelik genel bir anlayışa sahip olmalarına rağmen, ispat yapma ve problem çözme sürecini nasıl ilerleteceklerini ve önceden sahip oldukları bilgileri amacına uygun bir biçimde nasıl kullanacaklarını bilemedikleri görülmüştür. Ayrıca uygulamaya katılan öğretmen adaylarına göre, sesli düşünme yöntemi üst düzey düşünmeyi geliştiren ve bireyin gerçekte ne düşündüğünü anlamasına imkân tanıyan bir yöntemdir.
In Silico Estimation of the Safety of Pharmacologically Active Substances Using Machine Learning Methods: A Review
Authors: Poroikov V. V. , Dmitriev A. V. , Druzhilovskiy D. S. , Ivanov S. M. , Lagunin A. A. , Pogodin P. V. , Rudik A. V. , Savosina P. I. , Tarasova O.  A. , Filimonov D. A.
Published: December 2023

Scientific relevance. Currently, machine learning (ML) methods are widely used in the research and development of new pharmaceuticals. ML methods are particularly important for assessing the safety of pharmacologically active substances early in the research process because such safety assessments significantly reduce the risk of obtaining negative results in the future.

Aim. This study aimed to review the main information and prediction resources that can be used for the assessment of the safety of pharmacologically active substances in silico.

Discussion. Novel ML methods can identify the most likely molecular targets for a specific compound to interact with, based on structure–activity relationship analysis. In addition, ML methods can be used to search for potential therapeutic and adverse effects, as well as to study acute and specific toxicity, metabolism, and other pharmacodynamic, pharmacokinetic, and toxicological characteristics of investigational substances. Obtained at early stages of research, this information helps to prioritise areas for experimental testing of biological activity, as well as to identify compounds with a low probability of producing adverse and toxic effects. This review describes free online ML-based information and prediction resources for assessing the safety of pharmacologically active substances using their structural formulas. Special attention is paid to the Russian computational products presented on the Way2Drug platform (https://www.way2drug.com/dr/).

Conclusions. Contemporary approaches to the assessment of pharmacologically active substances in silico based on structure–activity relationship analysis using ML methods provide information about various safety characteristics and allow developers to select the most promising candidates for further in-depth preclinical and clinical studies.
Evaluation of Nephrotoxic Properties of Favipiravir Using the RPTEC cell model
Authors: Evteev V. A. , Semenova I. S. , Bunyatyan N. D. , Prokofiev A. B.
Published: December 2023

Scientific relevance. Favipiravir is an antiviral RNA polymerase inhibitor used to treat COVID-19. An adverse drug reaction associated with the use of favipiravir is renal disorder.

Aim. This study aimed to investigate favipiravir nephrotoxicity by assessing its effects on the integrity of a monolayer formed by renal proximal tubular epithelial cells (RPTECs).

Materials and methods. This study focused on an RPTEC monolayer culture that was seeded at a density of 6×104 cells/cm2 on plates with membrane inserts with 0.4 μm pores. Favipiravir was added to the plate wells at a concentration of 5, 10, or 15 μg/mL. The nephrotoxicity evaluation relied on measuring the transepithelial electrical resistance (TEER) of the RPTEC monolayer. A TEER value of 120–140 Ω×cm2 was considered an indication of nephrotoxicity.

Results. RPTEC incubation with favipiravir led to a dose-dependent decrease in the TEER values. However, the TEER values after 6 days of incubation ranged within 250–280 Ω×cm2 and were above the critical threshold

of 120–140 Ω×cm2.

Conclusions. The results of this study indicate that favipiravir has no pronounced effect on the TEER of the RPTEC monolayer.
Новые перспективные образцы повышенного качества зеленой массы костреца безостого
Authors: Юсова Оксана Александровна , Николаев Петр Николаевич , Глушаков Денис Александрович
Published: December 2023

В Сибири многолетние травы занимают 30 % площади кормовых культур. Основной кормовой культурой среди злаковых многолетних трав является кострец безостый, который, помимо всего прочего, обеспечивает низкую себестоимость кормов. Представлена характеристика 12 новых перспективных образцов костреца безостого с повышенным качеством зеленой массы. Исследования проводили с 2019 по 2021 г. Биохимические показатели определяли с использованием современных и традиционных методов и технологий. Рассчитана адаптивность исследуемых образцов, стандартом выступал сорт костреца безостого СибНИИСХоз 189. Зеленая масса растений костреца безостого 1-го года пользования является более питательной, по сравнению с зеленой массой 2-го года пользования (превышение по массовой доле белка составляет 0,8 %). Для дальнейшей селекционной работы рекомендуются следующие образцы: сорт СибНИИСХоз 99, линия СП-2-11/13-11: интенсивны по массовой доле белка (bi > 1) и экстенсивны по массовой доле клетчатки (bi < 1); сорта СибНИИСХоз 88 и Эльбрус, линия СП-2-11/13-33: экстенсивны по массовой доле клетчатки (bi < 1), превышают стандарт по белковости зеленой массы на 0,7 – 1,7 %.
Discovering the relationships between event identity, satisfaction, image, WoM, and re-participation intention
Authors: Özgen Caner , Köse Hüseyin , Reyhan Servet
Published: December 2023

Although small-scale dance events are popular as a postmodern socialization tool for modern people, little is known about participants’ behavioral intentions in active small-scale dance events. This research examined the hierarchical relationship between event image, event satisfaction, event identity, and behavioral intentions, including re-participation intention and positive word-of-mouth (WoM) behavior, in a repeated small-scale dance event. A total of 412 participants of the Eskisehir Dance Festival (EDF), a repeated small-scale dance event, were reached by the convenience sampling method. Research data were analyzed using structural equation modeling (SEM). First, the model’s compatibility with the data was evaluated by applying confirmatory factor analysis to the model, which includes all research structures. AVE, Cronbach alpha, and CR values were analyzed for all constructs. The conceptual model of the research was analyzed using the AMOS v22. Event image is an important predictor of both event satisfaction (β =0.88; p <0.01) and event identity (β =0.46; p <0.01). In addition, event satisfaction significantly impacted event identity (β =0.76; p <0.01). Event identity is the predictor of re-participation intention (β =0.24; p <0.01) and positive WoM behavior (β =0.88; p <0.01). Finally, WoM behavior positively affected reparticipation intention (β =0.88; p <0,01). Research results made significant empirical contributions to the literature on repeated small-scale dance events. In addition, based on the research results, suggestions were presented to managers of small-scale dance events that they could use in their marketing strategies.
Síndrome de la arteria mesentérica superior (Síndrome de Wilkie): a propósito de un caso en una adolescente
Authors: Lozano-Vega José Jorge , Mejía-Sanguino Sebastián , Gaviria-Gallego David Alejandro , Polanco-Cabrera Juan Pablo
Published: December 2023

Introducción. El síndrome de la arteria mesentérica superior, también conocido como síndrome de Wilkie, es una entidad infrecuente en la que una reducción del ángulo o espacio aorto-mesentérico determina una compresión extrínseca con obstrucción del tercio distal del duodeno, demostrando síntomas y signos característicos de obstrucción intestinal. El pilar del tratamiento es el manejo médico conservador con repleción nutricional, con el objetivo de aumentar el grosor de la grasa retroperitoneal y con esto resolver la compresión duodenal.
Caso clínico. Paciente de 16 años, con un curso crónico marcado por dolor abdominal, estreñimiento, distensión, pirosis y pérdida de peso. Inicialmente se trató como una enfermedad ácido-péptica, con pobre mejoría, por lo que se realizaron estudios imagenológicos con lo que se documentó una disminución del ángulo aortomesentérico.
Resultado. Se instauró un manejo médico con un protocolo de repleción nutricional por vía oral, para lograr ganancia de peso y evitar la cirugía.
Conclusión. Con base a los síntomas y hallazgos en imágenes diagnósticas se hizo el diagnóstico de síndrome de la arteria mesentérica superior, que es una causa de obstrucción intestinal con muy baja incidencia. Su presentación clínica incluye gran variedad de síntomas, entre los que destaca el dolor abdominal y la pérdida de peso. Es frecuente la confusión con otras enfermedades más frecuentes, como enfermedad ácido-péptica, reflujo gastrointestinal y malabsorción. Su diagnóstico requiere un alto índice de sospecha, por lo que es importante conocer esta entidad y considerarla en el estudio de pacientes con los síntomas mencionados.
Herramientas para el tamizaje de aneurisma de aorta abdominal
Authors: Hernández-Peñuela Mayra Angelica , Hosman Manuel Augusto , Brito-Rojas Isabel Cristin , Carolina Riscanevo Angie Carolina , Muñoz Juan Fernando , Cabrera Luis Felipe , Mejía Gabriel , Varela Juan
Published: December 2023

Introducción. El aneurisma de la aorta abdominal (AAA) es la dilatación de la aorta abdominal mayor de 1,5 veces el diámetro esperado. Su prevalencia es variable, con tasas reportadas de hasta el 12,5 %. Se considera como causa de muerte de más de 10.000 personas al año en los Estados Unidos. El objetivo de esta revisión de la literatura fue describir los factores de riesgo y las herramientas de tamizaje de AAA.
Métodos. Se realizó una búsqueda de la literatura utilizando dos ecuaciones en bases de datos electrónicas, empleando términos seleccionados de “Medical Subject Heading” (MeSH) y “Descriptores en Ciencias de la Salud” (DeCS). Se evaluó la calidad de los estudios con la herramienta STROBE (Strengthening the Reporting of Observational Studies in Epidemiology).
Resultados. Se recolectaron 40 artículos y a partir de ellos se construyó el texto de revisión, identificando en estos, los factores de riesgo asociados al desarrollo de AAA, tales como sexo masculino, tabaquismo, hipertensión arterial, antecedente familiar y obesidad, entre otros. La diabetes mellitus parece actuar como factor protector. Dentro de los instrumentos de tamizaje, el ultrasonido abdominal es uno de los más usados.
Conclusión. El AAA es una patología multifactorial. En la actualidad la ultrasonografía de aorta es el método de elección para el tamizaje, permitiendo la detección precoz. El tamizaje de AAA con métodos no invasivos, como el ultrasonido, es útil sobre todo en zonas con prevalencia alta de la patología y en pacientes con determinados factores de riesgo.
Epidemiología de la apendicitis aguda en Colombia: un análisis de las bases de datos administrativas del Ministerio de Salud
Authors: Bottia Santiago , Lacouture Isabella , Rugeles Saúl , Rosselli Diego
Published: December 2023

Introducción. La apendicitis aguda es una afección común, con un pico de incidencia entre los 10 y 20 años. La cirugía es el tratamiento preferido y la apendicectomía por laparotomía sigue siendo el estándar, aunque el abordaje laparoscópico ha mostrado menos complicaciones. El objetivo de este artículo fue caracterizar tanto la enfermedad como el tratamiento quirúrgico en Colombia, usando datos de bases oficiales.
Métodos. Se accedió a la base de datos del Sistema Integrado de Información para la Protección Social (SISPRO) del Ministerio de Salud de Colombia en febrero de 2023. Se recogieron datos de los pacientes con diagnóstico de apendicitis y con procedimiento de apendicectomía entre 2017 y 2021, y se analizaron por edad, sexo y ubicación geográfica.
Resultados. Entre 2017 y 2021 se diagnosticaron 345.618 casos de apendicitis (51,8 % mujeres), con pico de incidencia a los 15-20 años. Se realizaron 248.133 apendicectomías, el 16,7 % por laparoscopia. Los hospitales con más procedimientos reportados estaban en Bogotá, Yopal, Popayán y Florencia. La mortalidad fue de 0,56 % en hombres y 0,51 % en mujeres.
Conclusión. La apendicitis es común, con pico a los 10-19 años. Las mujeres tienen mayor probabilidad de apendicectomía, debido a otras afecciones ginecológicas. El acceso a la apendicectomía disminuye la mortalidad; en estos pacientes, el 16 % fue laparoscópica, lo que sugiere que se necesita más entrenamiento y acceso a esta técnica. Este estudio aporta a la comprensión de la epidemiología de la apendicitis y apendicectomías en Colombia.
A Mathematical Analysis of Team Impact and Individual Player Contribution in Football
Authors: Leela Jeffrey , Comissiong Donna M. G. , Rahaman Karim
Published: December 2023

In this paper, we present an important application of the Hungarian Method - a well-known combinatorial optimization tool for solving assignment problems. For our purposes, we consider the assignment of players to specific roles in a football team. It involves the broad classification of team players as defensive, midfield or attacking, while assigning the main roles associated with each of these positions. This provides insight on specific role of each individual player, thereby facilitating an optimal team selection. To illustrate this method, we utilize the average player statistics per game for two teams from the 2016/2017 Premier League Season. In addition, a team rating index is created by identifying six sub-indices. The first is called team contributions - which includes set piece goals, percentage tackles won, percentage take-ons won, percentage aerial duels won, number of interceptions, number of blocked shots, number of clearances, number of red and yellow cards. To visualize the method, a multiple correlation is carried out on team data for the 2016/2017 Premier League season to generate a correlation coefficient for each contribution. The resulting team index can be a useful tool for measuring the overall strengths of competing teams in a football league. Keywords: Hungarian method, football, team rating index, multiple correlations, team comparisons
Hankel and Toeplitz determinants for a subclass of analytic functions
Authors: Buyankara M. , Çağlar M.
Published: December 2023

Let the function $f\left( z \right) =z+\sum_{k=2}^{\infty}a{_{k}}z {^{k}}\in A$ be locally univalent for $z \in \mathbb{D}%:=\{z \in \mathbb{C}:{|}z {|}<1\}$ and $0\leq\alpha<1$.Then, $f$\textit{\ }$\in $ $M(\alpha )$ if and only if \begin{equation*}\Re\Big( \left( 1-z ^{2}\right) \frac{f(z )}{z }\Big) >\alpha,\quad z \in \mathbb{D}.\end{equation*}%Due to their geometrical characteristics, this class has a significantimpact on the theory of geometric functions. In the article we obtain sharp bounds for the second Hankel determinant \begin{equation*}\left\vert H_{2}\left( 2\right) \left( f\right) \right\vert =\left\verta_{2}a_{4}-{a_{3}^{2}}\right\vert \end{equation*}and some Toeplitz determinants \begin{equation*}\left\vert {T}_{3}\left( 1\right) \left( f\right) \right\vert =\left\vert 1-2%{a_{2}^{2}}+2{a_{2}^{2}}a_{3}-{a_{3}^{2}}\right\vert,\ \\left\vert {T}_{3}\left( 2\right) \left( f\right) \right\vert =\left\vert {%a_{2}^{3}}-2a_{2}{a_{3}^{2}}+2{a_{3}^{2}}a_{4}-a_{2}{a_{4}^{2}}\right\vert \end{equation*}of a subclass of analytic functions $M(\alpha )$ in the open unit disk $%\mathbb{D}$.
On an attempt to introduce a notion of bounded index for the Fueter regular functions of the quaternionic variable
Authors: Baksa V. P. , Bandura A. I.
Published: December 2023

There is introduced a concept of index for the Fueter regular function of the quaternionic variables. There are considered three approaches (Fueter, Sudbery and Mariconda) constructing the Fueter regular function from a holomorphic function of complex variable. Using Mariconda's approach there are constucted some analogs of such elementary functions as the exponent, the sine and the cosine. For the Mariconda analogs we proved that they have bounded index and their indices equal 1, 2, 2, respectively. Using recent results on sum of entire functions whose derivatives are of bounded index it is established that the Fueter regular function constructed by Mariconda's approach is of bounded index, if the derivatives of its addends have bounded index. Also there was examined a function of the form $H(q)=f_1(x_0+ix_1)+jf_2(x_2+ix_3)$, where $f_1$ and $f_2$ are entire functions of complex variable. For the function $H$ it is proved its Fueter regularity and index boundedness if the first order derivatives of $f_1$ and $f_2$ have bounded index. Moreover, the index of the function $H$ does not exceed the maximum of indices of the functions $f'_1$ and $f'_2$ increased by $1$.
Bank Crisis Management Policies and the New Instability
Authors:   HSE University, Moscow, Russian Federation, Patalaha A. , Shchepeleva M.A. ,   HSE University, Moscow, Russian Federation
Published: December 2023

This research focuses on the determinants of banking crises. Despite all efforts to create systems of leading indicators, banking crises still occur, leading to negative consequences not only in the financial but also in the real sector of the economy. Our objective is to figure out how the characteristics of past banking crises, in particular the amount of liquidity support provided by the government, are related to the probability of subsequent banking crises. To accomplish this task, we use a classification tree methodology which we apply to a sample of 56 countries over the period 2000–2021. In addition to the characteristics of past crisis episodes, we add to the list of potential predictors of banking crises indicators related to the depth, structure and efficiency of the banking sector; institutional and macroeconomic indicators; and the index of macroprudential policy. To test the robustness of our results, we perform variable selection through Bayesian model averaging. Our results suggest that liquidity support during the past banking crisis is important for future crises. We demonstrate that excessive government support aimed at stabilizing the system during a crisis may affect future banking sector stability mainly by increasing the level of moral hazard in the financial system.
Non-resource Revenues to the Consolidated Budget: Analysis by Types of Economic Activity
Authors:   Economic Expert Group, Moscow, Russian Federation, Osmolovskaya-Suslina A .L. ,   Financial Research Institute, Moscow, Russian Federation, Borisova S. R. ,   Economic Expert Group, Moscow, Russian Federation,   Financial Research Institute, Moscow, Russian Federation
Published: December 2023

This paper presents an analysis of non-resource revenues of the consolidated budget of Russia by types of economic activity. The purpose of this study was to identify which sectors are the most sensitive to shocks form the fiscal point of view, and to answer the questions: how long it takes for the revenues of different sectors recover from “local lows” and how the sectoral structure of budget revenues affects the volatility of payments. In accordance with the set objectives, we examined the dynamics of consolidated budget revenues in real terms for the period 2008–2022 as a whole and by sector. In addition, a sectoral analysis was provided for CIT. The calculations were based on the data of the Federal Tax Service prepared by excluding payments on natural rent. The analysis showed that revenue fluctuations are largely determined by the dynamics of payments from the extractive sector (especially oil production), and an increase in the sector’s share is likely to increase the overall volatility of revenues. In fiscal terms, the processing sector is the most sustainable for total revenues but provides a source of volatility in CIT dynamics. Revenues from financial activities show the fastest recovery from the crises. Trade and finance have a stabilizing effect on both total revenues and CIT dynamics. The results of the study can be used at the stage of budget planning.
Historical aspects of the participation of Kazakhs in the First World War
Authors: Zhussip Sultan-Khan , Maslov Khalil , Syzdykov Satay , Kozybayeva Makhabbat , Zhumataу Samat , Tuleubayev Janibek
Published: December 2023

In the article, the authors explore the historical aspects of the participation of the Kazakhs in the First World War. Like other representatives of “foreign” peoples, the Kazakhs for the most part were not called to the front, but worked in the rear. The authors note the great role of the Alash movement, headed by A.N. Bukeikhan in support of compatriots in the rear of the Western Front.
Jonas, Archbishop of Novgorod, and the Question of the Canonical Subordination of the Novgorod Diocese (To the History of the Struggle of the Moscow and Lithuanian Parties in Novgorod)
Authors:   HSE University, Uspenskij Boris
Published: December 2023

The present work aims to demonstrate that St. Jonas, Archbishop of Novgorod (1458–1470)—the last independent Archbishop of Veliky Novgorod—was a supporter of the Lithuanian party, and not at all an adherent of Moscow, as hagiographic tradition claims and is commonly thought. In particular, he wanted his successor to be consecrated not in Moscow, but in Kiev (i.e., in Lithuanian Rus’). In this connection, In this connection we consider the question: whether Jonas promised not to recognize Gregory the Bulgarian, who was appointed in Rome to the metropolitan see of Kiev.