bluuebunny/crossref_metadata_2025 huggingface dataset:
Oxide‐Encapsulated Silver Electrocatalysts for Selective and Stable Syngas Production from Reactive Carbon Capture Solutions
Authors: Lin Zhexi , Blake Nathaniel , Pang Xueqi , He Zhirui , Mirshekari Gholamreza , Romiluyi Oyinkansola , Son Yoon Jun , Kabra Suryansh , Esposito Daniel V.
Published: May 2024

Electrolysis of bicarbonate‐containing CO2 capture solutions is a promising approach towards achieving low‐cost carbon‐neutral chemicals production. However, the parasitic bicarbonate‐mediated hydrogen evolution reaction (HER) and electrode instability in the presence of trace impurities remain major obstacles to overcome. This work demonstrates that the combined use of titanium dioxide (TiO2) overlayers with the chelating agent ethylene diamine tetra‐acetic acid (EDTA) significantly enhances the selectivity and stability of Ag‐based electrocatalysts for bicarbonate electrolysis. The amorphous TiO2 overlayers suppress the HER by over 50 % at potentials more negative than −0.7 V vs. RHE, increasing the CO faradaic efficiency (FE) by 33 % (relative). In situ surface‐enhanced Raman spectroscopy (SERS) measurements reveal the absence of near‐surface bicarbonate species and an abundance of CO2 reduction intermediates at the Ag|TiO2 buried interface, suggesting that the overlayers suppress HER by blocking bicarbonate ions from reaching the buried active sites. In accelerated degradation tests with 5 ppm of Fe(III) impurity, the addition of EDTA allows stable CO production with >47 % FE, while the electrodes rapidly deactivate in the absence of EDTA. This work highlights the use of TiO2 overlayers for enhancing the CO : H2 ratio while simultaneously protecting electrocatalysts from impurities likely to be present in “open” carbon capture systems.
Chiral Teropyrenes: Synthesis, Structure, and Spectroscopic Studies
Authors: Bam Radha , Yang Wenlong , Longhi Giovanna , Abbate Sergio , Lucotti Andrea , Tommasini Matteo , Franzini Roberta , Villani Claudio , Catalano Vincent J. , Olmstead Marilyn M. , Chalifoux Wesley A.
Published: May 2024

We present the inaugural synthesis of a chiral teropyrene achieved through a four‐fold alkyne benzannulation catalyzed by InCl3, resulting in good yields. The product underwent thorough characterization using FT‐Raman and FT‐IR spectroscopies, demonstrating a close agreement with calculated spectra. X‐ray crystallographic analysis unveiled a notable twist in the molecule‘s backbone, with an end‐to‐end twist angle of 51°, consistent with computational predictions. Experimentally determined enantiomeric inversion barriers revealed a significant energy barrier of 23 kcal/mol, facilitating the isolation of enantiomers for analysis by circular dichroism (CD) and circularly polarized luminescence (CPL) spectroscopies. These findings mark significant strides in the synthesis and characterization of chiral teropyrenes, offering insights into their structural and spectroscopic properties.
Force Transduction Through Distant Force‐Bearing Regioisomeric Linkages Affects the Mechanochemical Reactivity of Cyclobutane
Authors: Flear Erica J. , Horst Matías , Yang Jinghui , Xia Yan
Published: May 2024

Fundamental understanding of mechanochemical reactivity is important for designing new mechanophores. Besides the core structure of mechanophores, substituents on a mechanophore can affect its mechanochemical reactivity through electronic stabilization of the intermediate or effectiveness of force transduction from the polymer backbone to the mechanophore. The latter factor represents a unique mechanical effect in considering polymer mechanochemistry. Here, we show that regioisomeric linkage that is not directly adjacent to the first cleaving bond in cyclobutane can still significantly affect the mechanochemical reactivity of the mechanophore. We synthesized three non‐scissile 1,2‐diphenyl cyclobutanes, varying their linkage to the polymer backbone via the o, m, or p‐position of the diphenyl substituents. Even though the regioisomers share the same substituted cyclobutane core structure and similar electronic stabilization of the diradical intermediate from cleaving the first C−C bond, the p isomer exhibited significantly higher mechanochemical reactivity than the o and m isomers. The observed difference in reactivity can be rationalized as the much more effective force transduction to the scissile bond through the p‐position than the other two substitution positions. These findings point to the importance of considering force‐bearing linkages that are more distant from the bond to be cleaved when incorporating mechanophores into polymer backbones.
SERS Detection of Trace Carcinogenic Aromatic Amines Based on Amorphous MoO3 Monolayers
Authors: Meng Xiangyu , Yu Jian , Shi Wenxiong , Qiu Lin , Qiu Keliang , Li Anran , Liu Zhen , Wang Yuening , Wu Jingjing , Lin Jie , Wang Xiaotian , Guo Lin
Published: May 2024

Aromatic amines are important commercial chemicals, but their carcinogenicity poses a threat to humans and other organisms, making their rapid quantitative detection increasingly urgent. Here, amorphous MoO3 (a‐MoO3) monolayers with localized surface plasmon resonance (LSPR) effect in the visible region are designed for the trace detection of carcinogenic aromatic amine molecules. The hot‐electron fast decay component of a‐MoO3 decreases from 301 fs to 150 fs after absorption with methyl orange (MO) molecules, indicating the plasmon‐induced hot‐electron transfer (PIHET) process from a‐MoO3 to MO. Therefore, a‐MoO3 monolayers present high SERS performance due to the synergistic effect of electromagnetic enhancement (EM) and PIHET, proposing the EM‐PIHET synergistic mechanism in a‐MoO3. In addition, a‐MoO3 possesses higher electron delocalization and electronic state density than crystal MoO3 (c‐MoO3), which is conducive to the PIHET. The limit of detection (LOD) for o‐aminoazotoluene (o‐AAT) is 10−9 M with good uniformity, acid resistance, and thermal stability. In this work, trace detection and identification of various carcinogenic aromatic amines based on a‐MoO3 monolayers is realized, which is of great significance for reducing cancer infection rates.
Ligand‐free CuO nanoparticles catalyzed S‐arylation of heterocyclic thiols using aryl halides
Authors: Kataky Sudhamoyee , Rakshit Ankita , Ahmed Sultana Parveen , Kalita Bikash Kumar , Sarma Bipul , Thakur Ashim J.
Published: May 2024

A simple and efficient approach for the S‐arylation of tetrazole‐5‐thiol using copper oxide nanoparticles has been developed. Recently, heterocyclic thiols have attracted a great deal of interest due to their diverse biological and pharmacological properties. Thus, great efforts have been devoted in introducing efficient protocols for the synthesis of such compounds. The utilization of copper oxide nanoparticles has been substantially chosen for catalysis due to their low cost, high surface area, sustainability, and reusability. The distinctive features of this methodology involve a ligand‐free catalytic system, simple reaction procedure, shorter reaction time, wide substrate scope compatibility, and high yield of the products.
Synthesis, structural investigations, in vitro cytotoxicity, apoptotic activity, cell cycle analysis, and molecular modeling studies of nano‐sized Zn(II) Schiff base complex
Authors: Amri Nasser , Alaghaz Abdel‐Nasser M. A.
Published: May 2024

A new novel tetradentate ligand, [(1E,1′E)‐N,N′‐(1,2‐phenylene)bis(1‐(5‐(2‐fluorophenyl)furan‐2‐yl)methanimine) (PFPFMI), and its nano‐sized [Zn(PFPFMI)Cl2].3H2O complex were synthesized. The geometry of PFPFMI and its Zn(II) complex was described through CHN analyses, Fourier‐transform infrared spectroscopy (FTIR), UV–visible, X‐ray diffraction (XRD), thermal gravimetric analysis (TGA), and mass spectral data tests. The spectral data of the nano‐sized [Zn(PFPFMI)Cl2].3H2O complex indicates that the PFPFMI ligand functions as a tetradentate (N2O2) coordination through two azomethine nitrogen groups (N) and two furan ring oxygen (O) atoms. Density functional theory (DFT) calculations were performed using the molecular studio software to investigate the optimal geometry of PFPFMI and its [Zn(PFPFMI)Cl2].3H2O complex. The SEM, TEM, XRD, AFM, and energy dispersive X‐ray analysis (EDX) analyses of the studied complex unveil distinct and strong diffraction peaks, indicating its crystalline nature and providing evidence of its nano‐sized particle sizes. Additionally, the inhibition zone diameter was used to assess the in vitro antimicrobial action of PFPFMI and the particular complex against Gram‐positive bacteria Streptococcus pneumonia and Bacillus subtilis, Gram‐negative bacteria Pseudomonas aeruginosa, Salmonella typhi, and Escherichia coli, as well as fungi Aspergillus fumigatus, Geotricum candidum, Syncephalastrum racemosum, and Candida tropicalis. The [Zn(PFPFMI)Cl2].3H2O complex exhibits higher activity than the ligand PFPFMI. In vitro cytotoxicity of the synthesized [Zn(PFPFMI)Cl2].3H2O complex was explored using MCF7 (breast cancer), HCT116 (colon cancer), A549 (lung cancer), HePG‐2 (liver cancer), A375 (melanoma cancer), and normal lung fibroblast (WI38) cell lines. Based on IC50 and selective index (SI) values, it was shown that the complex exhibited higher potency against MCF7 cell lines. Moreover, the Zn(II) complex exhibited the ability to induce DNA damage in MCF7 cells, resulting in dose‐dependent cell apoptosis. Subsequent investigations revealed that complex 2 also induced cell cycle arrest in the G2 and S phases.
Progress and Prospect of Sn‐based Metal‐organic Framework Derived Anode Materials for Metal‐ion Batteries
Authors: Zhang Weitao , Qi Yongyu , Fang Jie , Mai Wanxin , Lin Xiaoming , Yang Huachao , Wu Yongbo
Published: May 2024

In order to realize the growing demand for superior energy storage devices and electric vehicles, commercial anode candidates for next‐generation rechargeable batteries need to meet the characteristics of low cost, high energy density, high capacity, and stable performance. The emerging tin‐based anodes show great potential for high performance metal‐ion battery anodes due to their high theoretical capacity, low cost, green harmless and high safety. Tin based anode materials include tin gold based materials, tin alloy materials, tin based oxides, tin based phosphide, tin based sulfides, multi‐component composite materials, etc. However, the change in volume and structure of tin‐based anode materials during the cycle has become the biggest obstacle to its development. Metal‐organic frameworks (MOFs) provide a wide range of possibilities for achieving high rate capacity and excellent cycle stability by finely regulating the structure and composition of tin‐based materials at the molecular level. The latest progress of tin‐based materials derived from MOFs as anode materials for metal‐ion batteries (including lithium ion batteries, sodium ion batteries, potassium ion batteries, magnesium ion batteries) was reviewed in this paper. Firstly, the preparation method and morphology control of tin‐based MOF are briefly introduced, and the structural characteristics, storage mechanism and modification of tin‐based MOF derived materials are emphatically discussed. Finally, we summarized the existing modification measures and challenges of these anode materials, and put forward the prospect of the future.
The effects of an online positive psychology intervention on pre‐service teachers' efficacy, ability to cope and emotional regulation
Authors: Hoferichter Frances , Jentsch Armin
Published: May 2024

Pre‐service teachers have been identified as a risk group for developing burnout syndromes over the course of their careers due to increased perceived psychological distress and, in particular, if there is a lack of coping strategies. To provide pre‐service teachers with appropriate techniques and concepts that can be successfully applied in educational and work contexts, an online positive psychology intervention was designed to improve participants' resilience, in particular their self‐efficacy, emotion regulation and ability to cope. Linear mixed models that simultaneously analyse variability between subjects and over time revealed that pre‐service teachers who participated in the intervention benefited from the programme with respect to an increase of their emotion regulation strategies, self‐efficacy and ability to cope compared to the control group—although at baseline, they exhibited less beneficial emotion regulation, self‐efficacy and ability to cope. The findings suggest that such positive psychology interventions could help pre‐service teachers build their resilience.
Using the Performance Diagnostic Checklist‐Human Services to assess and increase teacher token delivery
Authors: Hoffmann Audrey N. , Pastina Colleen
Published: May 2024

Staff implementation fidelity of behavioral interventions is an ongoing challenge in many educational settings. The Performance Diagnostic Checklist‐Human Services (PDC‐HS) is one tool that may be effective in identifying effective solutions to identified staff performance issues. This study examined the use of the PDC‐HS to assess and identify interventions for increasing staff delivery of token reinforcers within a Positive Behavior Interventions and Supports (PBIS) school‐wide system. Participants included five classroom teachers, ranging from 2 to 22 years of teaching experience. A concurrent multiple baseline design across participants was used including a baseline condition, implementation of a non‐indicated intervention based on the PDC‐HS, and implementation of a PDC‐HS indicated intervention. The number of teacher‐delivered tokens per school day was measured across the study. Results indicated participants' daily number of delivered tokens increased following implementation of the PDC‐HS indicated intervention.
A dynamic nomogram for predicting pathologic complete response to neoadjuvant chemotherapy in locally advanced rectal cancer
Authors: Wang Guancong , Li Jiasen , Huang Ying , Guo Yincong
Published: May 2024

Aim

To explore the clinical factors associated with pathologic complete response (pCR) for locally advanced rectal cancer (LARC) patients treated with neoadjuvant chemoradiotherapy (nCRT) and develop a web‐based dynamic nomogram.

Methods

Retrospective analysis of patients with examination confirmed LARC from 2011 to 2022. Patients from the Union Hospital of Fujian Medical University were included as the training cohort (n = 1579) and Zhangzhou Hospital of Fujian Medical University as the external validation cohort (n = 246).

Results

In the training cohort, after nCRT, 350 (22.2%) patients achieved pCR. More stomas were avoided in pCR patients (73.9% vs. 69.7%, p = 0.043). After a median follow‐up time of 47.7 months (IQR 2–145) shown OS (5‐year: 93.7% vs. 81.0%, HR = 0.310, 95%CI: 0.189–0.510, p < 0.001) and DFS (5‐year: 91.2% vs. 75.0%, HR = 0.204, 95%CI: 0.216–0.484, p < 0.001) were significantly better among patients with pCR than non‐pCR. Multivariable Logistic analysis shown pCR was significantly associated with Pre‐CRT CEA (HR = 0.944, 95%CI: 0.921–0.968; p < 0.001), histopathology (HR = 4.608, 95%CI: 2.625–8.089; p < 0.001), Pre‐CRT T stage (HR = 0.793, 95%CI: 0.634–0.993; p = 0.043), Pre‐CRT N stage (HR = 0.727, 95%CI: 0.606–0.873; p = 0.001), Pre‐CRT MRI EMVI (HR = 0.352, 95%CI: 0.262–0.473; p < 0.001), total neoadjuvant therapy (HR = 2.264, 95%CI: 1.280–4.004; p = 0.005). Meanwhile, the online version of the nomogram established in this study was publicized on an open‐access website (URL: https://pcrpredict.shinyapps.io/LARC2/). The model predicted accuracy with a C‐index of 0.73 (95% CI: 0.70–0.75), with an average C‐index of 0.73 for the internal cross validation and 0.78 (95% CI: 0.72–0.83) for the external validation cohort, showing excellent model accuracy. Delong test results showed the model has an important gain value for clinical characteristics to predict pCR in rectal cancer.

Conclusions

Patients with pCR had a better prognosis, including OS and DFS, and were independently associated with Pre‐CRT CEA, histopathology, Pre‐CRT T/N stage, Pre‐CRT MRI EMVI, and TNT. A web‐based dynamic nomogram was successfully established for clinical use at any time.
Lumbar functional evaluation of pelvic bone sarcomas after surgical resection and spinal pelvic fixation: A clinical study of 304 cases
Authors: Shi Qianyu , Guo Wei , Ji Tao , Tang Xiaodong
Published: May 2024

Aims

We endeavored to introduce a novel scoring system (Lumbar Functional Index, LFI) capable of evaluating lumbar function in pelvic bone sarcoma patients who underwent surgical resection and spinal pelvic fixation, while simultaneously identifying the incidence, outcomes, and risk factors of lumbar function impairment among these populations.

Patients and Methods

A cohort of 304 primary bone sarcoma patients were recruited. The LFI was created based on the Oswestry Dysfunction Index (ODI) and Japanese Orthopaedic Association (JOA) scores. Lumbar function impairment was defined as LFI score ≥ 18 points, which was identified as high LFI. Demographic data, clinical characteristics, and oncological outcomes were analyzed.

Results

The cohort included chondrosarcoma (39.8%), osteosarcoma (29.9%), Ewing sarcoma (8.6%), bone‐derived undifferentiated pleomorphic sarcoma (7.2%), giant cell tumor of bone (7.2%), chordoma (2.3%), and other bone sarcomas (5.0%). The LFI score exhibited significant negative correlation with common scoring systems of bone sarcoma. The incidence of high LFI was 23.0%. Patients with high LFI demonstrated a higher prevalence of type I + II + III + IV pelvic tumor, more sacrificed nerve roots and bilateral lumbar spine fixation during surgery, while lower percentage of R0 resection and local control of pelvic tumor. Decreased median overall survival (30 vs. 52 months, p < 0.001) and recurrence‐free survival (14 vs. 24 months, p < 0.001) time were observed in these patients. Type I + II + III + IV pelvic tumor and sacrificed nerve roots≥2 were identified as risk factors for high LFI, while R0 resection and local control were identified as protective factors.

Conclusion

The LFI scoring system exhibited a significant negative correlation to current scoring systems. High LFI patients had worse prognosis and distinct characteristics. The risk factors of high LFI included type I + II + III + IV pelvic tumor and sacrificed nerve roots≥2, and the protective factors included R0 resection and local control.
Credit for military service in Colorado: A case study
Authors: Deickman Jeff , Mattox James , Morris Phillip A.
Published: May 2024

This study evaluates the implementation of policies and practices related to prior learning assessment (PLA) for military training and experience in Colorado community colleges. Through conducting interviews and a document analysis, this case study aimed to provide policy and practice recommendations for states, systems, and institutions to consider for military enrollment and PLA.
Patients journey to diagnosis and treatment of oral mucosal lesions: A report on three cases
Authors: Homeida Lujain A. , Aldahlawi Salwa A.
Published: May 2024

Key Clinical Message

Delays in diagnosis and management of patients with oral mucosal lesions have serious implications for the patients. Early referral and collaboration between HCPs and OM specialists are essential in improving patients' quality of life and outcomes.
Plenty of Space in the Backbone: Radical Ring‐Opening Polymerization
Authors: Sbordone Federica , Frisch Hendrik
Published: May 2024

Radical polymerization is the most widely applied technique in both industry and fundamental science. However, its major drawback is that it typically yields polymers with non‐functional, non‐degradable all‐carbon backbones—a limitation that radical ring‐opening polymerization (rROP) allows to overcome. The last decade has seen a surge in rROP, primarily focused on creating degradable polymers. This pursuit has resulted in the creation of the first readily degradable materials through radical polymerization. Recent years have witnessed innovations in new monomers that address previous design limitations, such as ring strain and reactivity ratios. Furthermore, advances in integrating rROP with reversible deactivation radical polymerization (RDRP) have facilitated the incorporation of complex, customizable chemical payloads into the main polymer chain. This short review discusses the latest developments in monomer design with a focused analysis of their limitations in a broader historical context. Recently evolving strategies for compatibility of rROP monomers with RDRP are discussed, which are key to precision polymer synthesis. The latest chemistry surveyed expands the horizon beyond mere hydrolytic degradation. Now is the time to explore the chemical potential residing in the previously inaccessible polymer backbone.
The relationship between oral frailty and oral dysbiosis among hospitalized patients aged older than 50 years
Authors: Chen Yen‐Chin , Ku En‐Ni , Tsai Pei‐Fang , Lin Che‐Wei , Ko Nai‐Ying , Huang Shun‐Te , Wang Jiun‐Ling , Yang Yi‐Ching
Published: May 2024

Objective

This study aimed to clarify the relationship between oral frailty and oral dysbiosis among hospitalized patients aged ≥ 50 years.

Methods

A prospective observational study was conducted. Number of teeth, masticatory ability, articulatory oral motor skill, tongue pressure, swallowing pressure, and choking were used to assess oral frailty. Saliva samples were collected from the oral cavity for bacterial culture.

Results

A total 103 in patients enrolled and 53.4% suffered from oral frailty. Oral frailty was found to have a 3.07‐fold correlation with the presence of Enterobacterales in the oral cavity (p = 0.037), especially in poor articulatory oral motor skill, which showed at greater risk of Enterobacterales isolated from the oral cavity by 5.58‐fold (p = 0.01).

Conclusion

Half of hospitalized patients was found to have oral frailty that was related to more Enterobacterales in the oral cavity. This evidence suggests that the enhancement of articulatory oral motor skills may serve as a potential strategy for mitigating the presence of Enterobacterales within the oral cavity.
New World dung beetle (Coleoptera: Scarabaeidae: Scarabaeinae) colonization of a recent Miocene insular territory: The case of Costa Rica
Authors: Kohlmann Bert , Salomão Renato Portela , Solís Ángel
Published: May 2024

Costa Rica emerged from the seas as a new geological territory during the Miocene as an insular archipelago. It later became part of a continental area once it became a segment of Central America. Two dung beetle genera that colonized this new territory from South and North America, Canthidium and Onthophagus (Coleoptera: Scarabaeidae: Scarabaeinae), are here studied, in the first analysis of a volcanic paleo‐archipelago, colonized from its emergence, and then later becoming terra firma. To assess their biodiversity distribution patterns, we analyzed the effect of biogeography, ecosystem origins, and body size on their altitudinal distribution patterns in three geographic basins of Costa Rica. Based on 32 years of collecting representing more than 158,000 specimens from 1017 localities, we undertook Generalized Linear Models of the two dung beetle genera to assess the effects of biodiversity and biogeographical distribution patterns. Canthidium and Onthophagus species ranged from 0 to 3000 m a.s.l., with an abrupt diversity decline at altitudes above 1500 m. Endemic species tended to show a higher altitudinal mean with a narrow altitudinal band distribution than non‐endemic dung beetle species. Although there was a trend of decreasing species body size with the increase in altitude, such a trend depended on the distribution pattern of the species group. This possible insular‐mediated endemicity mechanism has generated baffling biodiversity levels, considered the highest worldwide per unit area. Costa Rica is an expanse represented by a geographic overlap of two or more temporally disjunct areas and is not part of a natural transition zone. The effect of the insular Miocene origin of Costa Rica still pervades today, reflected by different insular syndromes shown by the dung beetle fauna. The importance of geological origins in generating biodiversity seems to have been an underrated criterion for conservation biology practices and should be considered ex officio.
Biochemical profile of Scenedesmus isolates, with a main focus on the fatty acid profile
Authors: Khodadadianzaghmari Faezeh , Jahadi Mahshid , Goli Mohammad
Published: May 2024

Biochemical characterization of new microalgal strains that are isolated from diverse environmental conditions is an important starting point for the establishment of high‐quality feedstock for nutraceutical and pharmaceutical applications. In this research study, the biochemical composition of three Iranian native subspecies of Scenedesmus microalgae (Scenedesmus obliquus, Scenedesmus bijugusi, and Scenedesmus sp.), with the main focus on fatty acid composition, was studied. The results showed that the strain Scenedesmus bijugusi had the highest biomass productivity (48 g/L/d), biomass (0.73%), carbohydrate (13.97%), fat (16.27%), protein (44.04%), chlorophyll‐a (6.32 mg/g), and carotenoids (3.7 mg/g). The lipid profile also revealed that S. obliquus had the highest percentage of polyunsaturated fatty acid (46.52%), ratio of ∑n‐3/∑n‐6 (5.96), ratio of polyunsaturated fatty acid to saturated fatty acid (PUFA/SAF) (1.18), α‐linolenic acid (22.74%), hypocholesterolemia index (1.61), and low atherogenic index (0.34). S. bijugusi and S. obliquus, thus, showed a great promise in nutraceutical and pharmaceutical applications due to their appropriate high productivity, biopigment, protein, lipid, antioxidant activity, long‐chain polyunsaturated fatty acids, and α‐linolenic acid.
Together in sickness and in health: Spillover of physical, mental, and cognitive health among older English couples
Authors: Jain Urvashi , Ma Mingming
Published: May 2024

Using data from eight waves of the English Longitudinal Study of Aging, we study the cross‐domain and cross‐spouse spillover of health among married adults aged 50 and above in England. We apply the system generalized method of moments to linear dynamic panel models for physical, mental, and cognitive health, controlling for individual heterogeneity and the influence of marriage market matching and shared environments. Our findings reveal bidirectional spillovers between memory abilities and mobility difficulty among men, as well as between depressive symptoms and mobility difficulty among women. Worsening mobility increases the risk of depression in men, but not vice versa. Additionally, gender‐specific cross‐spouse effects are observed. Women's mental health is significantly influenced by their spouse's mental health, while this effect is weaker for men. Conversely, men's mental health is notably affected by their spouse's physical health. These results highlight the importance of considering spillovers within families and across health domains when developing policies to promote health and reduce health disparities among the elderly population.
Investment in employee developmental climate and employees' continued online learning behaviors: A social influence perspective
Authors: Tan Jiahui , Zhu Cherrie Jiuhua , Zhang Mingqiong Mike
Published: May 2024

In the contemporary digital age, continued online learning behaviors have become indispensable for fostering employee development. However, the learning and development literature predominantly focuses on traditional instructor‐led approaches. It remains unclear how organizations can shape employees' learning behaviors, particularly in the context of online learning. The current study clarifies this underexplored research area by investigating how organizational investment in employee developmental climate (IEDC) can promote employees' continued online learning behaviors. Drawing on social influence theory and employing a multilevel research design, we find empirical support for our research model, which specifies that IEDC positively affects employees' continued online learning behaviors through the effect of normative pressure. The findings also reveal the moderating role of online learning facilitating conditions. Specifically, in firms characterized by higher levels of online learning facilitating conditions, the positive relationship between IEDC and normative pressure becomes more pronounced when compared to organizations with lower levels of such facilitating conditions.
Prediction of potential public health risk of the recent multicountry monkeypox outbreak: An update after the end declaration of global public health emergency
Authors: Haque Md. Aminul , Halder Angelina Samantha , Hossain Md. Jamal , Islam Md. Rabiul
Published: May 2024

Background and Aims

A double‐stranded DNA virus called monkeypox virus (MPV) belonging to the Poxviridae family and Orthopoxvirus genus causes monkeypox (mpox) infection. This virus used to infect only Central, East, and West Africa. However, it has spread to an extent outside Africa recently. The range of MPV outbreaks was so high that on July 23, 2022, the World Health Organization (WHO) declared it a Public Health Emergency of International Concern (PHEIC). About a year later, the WHO notified the end of a global public health emergency for mpox on May 11, 2023. Here, we aimed to assess the current pathogenicity and potential risk of MPV causing public health emergencies.

Methods

We searched information from published articles available in PubMed, Scopus, and ScienceDirect. We used monkeypox, mpox, monkeypox outbreak, and monkeypox virus as keywords during the literature search.

Results

Many new variants of MPV have emerged throughout the world that created PHEIC for mpox. Considering the low lethality and transmission rate, mpox is no longer a global public health threat. In addition, the availability of therapeutic and preventive measures helped the healthcare authorities fight the mpox infection in an efficient manner. In this review, we have portrayed the history and evolution of mpox from past to present and an idea of its future outcomes. Also, we have discussed the symptoms related to mpox and approved antiviral treatment strategies to fight off the infection in this piece. This review also emphasized the preventive guidelines set by the WHO for patients, caregivers, and healthcare providers to control the outbreak of mpox infection.

Conclusion

We believe this article would give an idea about the potential public health threats of the recent multi‐country monkeypox outbreak to the healthcare authorities for taking measures accordingly.
MSFNet‐2SE: A multi‐scale fusion convolutional network for Alzheimer's disease classification on magnetic resonance images
Authors: Zhang Liwen , Xia Rongwei , Yang Baiyang , Zhang Jincan , Wang Jinchan
Published: May 2024

Alzheimer's disease (AD) is an irreversible neurodegenerative disease, and the early diagnosis and effective intervention of AD is essential for patients and doctors. Intelligence diagnosis based on magnetic resonance imaging and deep learning has become one of the useful methods for AD identification. To improve the diagnosis effect of AD in early stages, a novel multi‐scale classification model of AD, called MSFNet‐2SE, is proposed. First, a new multi‐scale fusion (MSF) feature extraction module is designed based on the idea of the feature maps split into feature subsets of Res2Net. Second, a channel attention module is embedded into the MSF module through integrating two Squeeze‐and‐Excitation (SE) blocks. Finally, a gradient centralization Adam optimizer is used to improve the model classification performance. Experimental results illustrate that, compared with other available state‐of‐the‐art classification models of AD, the proposed model has excellent classification performance. It is helpful to improve the clinical diagnosis efficiency.
Optimizing irrigation for cactus (Opuntia ficus‐indica) fodder production under drought conditions in Kerman, Iran
Authors: Najafinezhad Hamid , Javaheri Mohmmad Ali , Koohi Nader , Ravari Seid Zabihallah , Asgharipour Mohammad Reza
Published: May 2024

Water scarcity and droughts are major challenges for cattle production in Iran due to the resulting feed shortages. Cactus plants were studied for 3 years (2017–2019) for their agronomic and water productivity. The study used a four‐replication randomized block design. Normal, moderate drought stress and severe drought stress irrigation were applied in 2017. The irrigation depths applied to the cactus plants were established by referencing cumulative pan evaporation values, with 100, 140 and 180 mm in 2017; 140, 190 and 240 mm in 2018; and 160, 210 and 260 mm in 2019, representing the total depth of water added during each irrigation event. In 2018 and 2019, the normal and severe drought stress treatments produced the most and least number of cladodes per plant, respectively. As dry stress increased, the cladode length, breadth and diameter decreased. Severe drought stress had the greatest potassium content and the lowest neutral detergent fibre (NDF) and acid detergent fibre (ADF) concentrations. Normal irrigation had the greatest effect on water productivity in 2018 and 2019. The usual treatment produced the greatest fresh and dry yields in 2018 (57.3 and 4.51 t ha−1) and 2019 (112 and 8.97 t ha−1). Under mild drought stress, the crude protein content was 8%, and under severe drought stress, it was 7%. The results suggest that Kerman, Iran, can grow cactus with less water.
Detection mechanism and solvent effects of the 3‐hydroxy‐2‐(4‐(pyrrolidin‐1‐yl)phenyl)benzo[g]quinolin‐4(1H)‐one (PBQ) probe
Authors: Zhang Meng , Li Jin , Li Jiaqi , Hou Yingmin , Wang Yi
Published: May 2024

Hydroxy‐2‐(4‐(pyrrolidin‐1‐yl)phenyl)benzo[g]quinolin‐4(1H)‐one (PBQ) is a ratiometric fluorescent probe based on excited‐state intramolecular proton transfer (ESIPT). PBQ‐1 is the reaction product following its exposure to phosgene. Density functional theory (DFT) and time dependent density functional theory (DFT) have been used to study the excited state dynamics of PBQ and PBQ‐1 in different solvents. The results show that the reaction of PBQ with a transition from charge‐transfer excitation to local excitation before and after the reaction. It becomes more difficult for PBQ in the excited state to transfer proton with increasing solvent polarity. The product PBQ‐1 undergoes a molecular structure twist, and the angle of twisting decreases with increasing solvent polarity, resulting in a lower degree of rotational freedom of the hydroxyl group (5‐OH) at the 5th carbon position, which makes it more susceptible to ESIPT reactions. Therefore, PBQ‐1 is more susceptible to ESIPT as solvent polarity increases. Our theoretical calculations also elucidate the cause of the blue shift of PBQ fluorescence and the impact of the twisting intramolecular charge transfer phenomenon on the solvent effect. Furthermore, our study provides the theoretical guidance for the designing probe based on excited state intramolecular proton transfer.
Novel Patient‐Friendly Orodispersible Formulation of Ivermectin is Associated With Enhanced Palatability, Controlled Absorption, and Less Variability: High Potential for Pediatric Use
Authors: Dao Kim , Buettcher Michael , Golhen Klervi , Kost Jonas , Schittny Andreas , Duthaler Urs , Atkinson Andrew , Haefliger David , Guidi Monia , Bardinet Carine , Chtioui Haithem , Boulekbache Abdelwahab , Buclin Thierry , Huwyler Jörg , Pfister Marc , Rothuizen Laura E.
Published: May 2024

Ivermectin has been used since the 1980s as an anthelmintic and antiectoparasite agent worldwide. Currently, the only available oral formulation is tablets designed for adult patients. A patient‐friendly orodispersible tablet formulation designed for pediatric use (CHILD‐IVITAB) has been developed and is entering early phase clinical trials. To inform the pediatric program of CHILD‐IVITAB, 16 healthy adults were enrolled in a phase I, single‐center, open‐label, randomized, 2‐period, crossover, single‐dose trial which aimed to compare palatability, tolerability, and bioavailability and pharmacokinetics of CHILD‐IVITAB and their variability against the marketed ivermectin tablets (STROMECTOL) at a single dose of 12 mg in a fasting state. Palatability with CHILD‐IVITAB was considerably enhanced as compared to STROMECTOL. Both ivermectin formulations were well tolerated and safe. Relative bioavailability of CHILD‐IVITAB compared to STROMECTOL was estimated as the ratios of geometric means for Cmax, AUC 0‐∞, and AUC0‐last, which were 1.52 [90% CI: 1.13‐2.04], 1.27 [0.99‐1.62], and 1.29 [1.00‐1.66], respectively. Maximum drug concentrations occurred earlier with the CHILD‐IVITAB formulation, with a median Tmax at 3.0 h [range 2.0‐4.0 h] versus 4.0 h [range 2.0‐5.0 h] with STROMECTOL (P = .004). With CHILD‐IVITAB, variability in exposure was cut in half (coefficient of variation: 37% vs 70%) compared to STROMECTOL. Consistent with a more controlled absorption process, CHILD‐IVITAB was associated with reduced variability in drug exposure as compared to STROMECTOL. Together with a favorable palatability and tolerability profile, these findings motivate for further clinical studies to evaluate benefits of such a patient‐friendly ODT formulation in pediatric patients with a parasitic disease, including infants and young children <15 kg.
Visible‐light photoredox catalyzed synthesis of tetrahydrobenzofuranone: Oxidative [3 + 2] cycloaddition of dicarbonyl and alkene
Authors: Kartikey  , Jaiswal Deepali , Singh Shailesh , Jaiswal Shefali , Saquib Mohammad , Singh Santosh , Verma Surya Pratap , Singh Jaya , Singh Jagdamba
Published: May 2024

Visible‐light‐mediated formation of tetrahydrobenzofuranone by direct oxidative [3 + 2] cycloaddition via coupling between dimedone and chalcone using eosin‐Y as a photoredox catalyst has been reported. The reaction takes place by a radical pathway as evidenced from our experiments and literature. The developed method involves the utilization of visible‐light photoredox catalysis for the formation of C‐C and C‐O bond via abstraction of methylinic hydrogen of dimedone and β‐carbon of chalcone as well as coupling between carbonyl group of dimedone and α‐carbon of chalcone in tetrahydrobenzofuranone in one‐pot procedure. The present protocol shows significant advantages such as the application of visible light as a clean source of energy, green solvent, mild reaction conditions, cost effectiveness, short reaction time, metal free synthesis, easy operation, high atom economy, and broad substrate scope with functional group tolerance. Moreover, outstanding yield of the product obtained up to 82%.
Exploring the contribution of low‐frequency internal variability modes to global mean sea surface temperature variability based on large ensembles
Authors: Yang Lu , Lin Pengfei , Liu Hailong , Zhao Bowen
Published: May 2024

Based on three large ensemble (LE) historical simulations, this study explored the contribution of low‐frequency internal variability (IV) modes to global mean sea surface temperature anomaly (GmSST) during 1920–2010. The dominant contributions of low‐frequency IV modes to GmSST in the three large ensembles are quite different. The low‐frequency IV modes in the Indo‐Pacific Ocean (i.e., IPO and IOBW) dominate the low‐frequency GmSST signal for the CESM2 and MPI LEs (the ensemble median contribution value reaches 70%–80%), while the low‐frequency IV modes in the North Atlantic dominate for the FGOALS‐g3 LE (contribute more than 50%). CESM2 LE and MPI LE can reasonably reproduce the impact of low‐frequency modes in the Indo‐Pacific ocean as observed, but FGOALS‐g3 LE underestimates this impact and overestimates the extratropical impact (on GmSST) of the North Atlantic. After removing the external forcing, it still retains the excessive signs in low‐frequency IV modes in FGOALS‐g3 LE over the North Atlantic. Furthermore, we used a pattern adjustment approach to revise the surplus effect in the North Atlantic. After revision, the contribution of decadal IVs in the North Atlantic to GmSST is reduced by 30%. Meanwhile, the tropical contribution in the Indo‐Pacific Ocean is increased and that is closer to the observed one. This approach can be employed to revise the weak or strong IV signals in other regions or LEs, which is meaningful for reducing the uncertainty of IV signals.
Climate change impacts on Central Asia: Trends, extremes and future projections
Authors: Fallah Bijan , Didovets Iulii , Rostami Masoud , Hamidi Mehdi
Published: May 2024

Central Asia (CA) is among the world's most vulnerable regions to climate change. Increasing anthropogenic greenhouse gas concentrations (GHGs) are the primary forcing of the current and future climate system for the time scale of a century. By analysing observation datasets, we show that a warming of 1.2°C led to a decrease of 20% in snow‐depth CA during the last 70 years, especially over the mountains. In recent decades, longer summer times and fewer icing days (more than 20 days·year−1) have exposed unprecedented shock to CA's climate system's components. Furthermore, we analyse 442 model simulations from Coupled Model Inter‐comparison Project Phase 5 and 6 (CMIP5, CMIP6) and show that CMIP6 simulations are generally warmer and wetter than the CMIP5 ones in CA. For instance, under the highest emission scenarios (RCP8.5 and SSP5‐8.5), CMIP6 projects a 6.1°C increase, while CMIP5 projects a 5.3°C increase, suggesting CMIP6 anticipates greater warming with high emissions. In contrast to CMIP6, the CMIP5 precipitation trends suggest a potential nonlinear relationship between increased greenhouse gas emissions and changes in precipitation, though the impact is much less pronounced than the temperature changes. Our analysis shows that CMIP6 models are more sensitive to temperature rise than CMIP5 ones. Both simulation sets' ensemble means capture well the observed warming trend. The imposed snow‐melting leads to an increase in the run‐off in the vicinity of glaciers. Such climatic shifts lead to more flooding events in CA. Given the projected warming range of 2–6°C in CA at the end of the century in various scenarios and models, such warming trends might be catastrophic in this region. The seasonal cycle of the temperature change indicates an extension of the glacier's melting period under future scenarios with fossil‐fueled development. The models' uncertainty increases for the far‐future time‐slice, and warming larger than 4°C in CA is very likely among all the models and during all the seasons if no sustainable action is taken. This study also incorporates a detailed Köppen climate classification analysis, revealing significant shifts towards warmer climate categories in Central Asia, which may have profound implications for regional hydrological cycles and water resource management, particularly in the Amu Darya and Syr Darya river basins under warmer scenario by the end of the century. The Tundra and ice cap climate categories will lose more than 60% of their coverage at the end of the century compared to the historical period in the Amu Darya and Syr Darya river basins.
Atlantic Multidecadal Oscillation modulates the relationship between North Pacific Oscillation and winter precipitation in North China Plain
Authors: Zheng Fei , Li Yuxun , Chen Jianhui , Huang Wei , Sun Cheng
Published: May 2024

The North China Plain, a crucial region for winter wheat cultivation, exhibits yield deeply affected by the variability of winter precipitation. This study examines the interdecadal variation in the relationship between the North Pacific Oscillation (NPO) and winter precipitation in the North China Plain (WPNC). Utilizing the East Asian winter monsoon (EAWM) as an intermediary, we have observed an interdecadal variation in the relationship between WPNC and NPO after the late‐1990s. Before 1994, the relationship between NPO and EAWM/WPNC both exhibited a significant positive correlation, while after 1998, their correlation decreased and became insignificant. This interdecadal variation can be attributed to the eastward shift of the winter NPO's location after the late‐1990s. Our investigation found that the eastward shift of the NPO's location is closely linked to the phase transition of the Atlantic Multidecadal Oscillation (AMO) phase after the late‐1990s. The warm sea surface temperatures (SST) over the North Atlantic cause ascending motion, and the outflows induce a compensatory anticyclonic circulation over the North Pacific. The easterlies anomaly on the south side of the anticyclone weakens climatological westerlies, increasing SST and upper‐level air temperatures in the North Pacific through the wind–evaporation–SST–longwave radiation effect. The resulting warmer air strengthens the atmospheric temperature gradient, enhancing the vertical integration of baroclinic energy conversion and shifting the NPO eastward, reducing its correlation with WPNC.
Carboxyl‐functionalized covalent organic frameworks for the extraction of malachite green and crystal violet in environmental water samples prior to quantification by high‐performance liquid chromatography
Authors: Lai Bingmei , Hu Haoyun , Tang Ningli , Huang Yipeng , Ruan Guihua
Published: May 2024

In this study, monodisperse, uniform, and spherical covalent organic frameworks (COFs) were synthesized using 1,3,5‐tris (4‐aminophenyl) benzene and 1,3,5‐tricarboxaldehyde benzene at room temperature. Post‐modification of 6‐aminocaproic acid on the COFs yielded carboxyl‐modified COFs (COFs‐COOH). The modification enhanced the hydrophilicity and adsorption efficiencies of COFs‐COOH for malachite green (MG) and crystal violet (CV). A COFs‐COOH‐based dispersive solid‐phase extraction coupled with high‐performance liquid chromatography was developed for the analysis of MG and CV. The method showed a linear range from 10 to 1000 ng/mL with detection limits of 1.82 and 0.70 ng/mL for MG and CV detection, respectively. The recoveries of MG and CV from water samples collected from fish farms and markets ranged from 91.63% to 107.10% with relative standard deviations below 5%. Reproducibility tests demonstrated that the adsorption efficiencies of COFs‐COOH were maintained at above 85.86% over 15 cycles. The study verified the potential of COFs‐COOH as sorbents for the enrichment and separation of triphenylmethane dyes from complex samples.
Efficient Fabrication of Bioinspired Flexible Pressure Sensors via Electrohydrodynamic Jet Printing Method
Authors: Shi Shiwei , Abbas Zeshan , Hu Xiaoguang , Zheng Xiaohu , Zhao Xiangyu , Ren Tongqun , Wang Dazhi
Published: May 2024

Bioinspired microdevices have made significant strides in various applications including human motion and health detection. However, facile and highly efficient fabrication approach of flexible pressure sensors remains a great challenge. Herein, inspired by the gecko's foot structure, a flexible pressure sensor with microdomes structure is fabricated by tip‐assisted on‐demand electrohydrodynamic jet (EHD‐jet) printing method. Ascribed to the interlocking electrodes with microdome structure, 3D deformation rates are substantially enlarged. When the microdromes structure is under pressure, the resistivity of carbon nanotubes film coated on the surface of microdomes structure will change remarkably. By using the combined effect of assisted tip and ring focusing electrode, the influence and constraints on microstructure fabrication caused by substrate material and morphology are minimized. The desired uniform structures can be adjusted rapidly by changing the printing parameters and liquid properties. High length‐height ratio (0.64) of microdomes enhances sensitivity, with minimum detection limit is 2 Pa and response time is 40 ms. Finally, the bionic flexible sensor indicated excellent performance in capable of detecting pressure, sound vibrations and human motion. This work presents a new method for high‐efficiency fabrication micro‐nano patterns for flexible sensors inspired, which could be used in wearable tech and health monitoring.