bluuebunny/crossref_metadata_2025 huggingface dataset:
Development and Population Results of a Fully Automated Homogeneous Assay for LDL Triglyceride
Authors: Ito Yasuki , Ohta Motoko , Ikezaki Hiroaki , Hirao Yuhko , Machida Asako , Schaefer Ernst J , Furusyo Norihiro
Published: July 2018

Background

Low-density lipoprotein (LDL) is measured by its cholesterol content (LDL-C), but it has been suggested that LDL triglyceride (LDL-TG) may also be related to coronary artery disease risk. LDL-TG can be measured after ultracentrifugation or electrophoresis, but these are labor intensive methods, indicating the need for an automated homogeneous assay.

Methods

TG-rich lipoproteins (TRLs), LDL, and HDL were isolated by ultracentrifugation and used to determine optimal characteristics of surfactants and various enzymes for assay development. We analyzed assay precision and linearity, and compared results with those obtained after ultracentrifugation. Serum samples from a large population study (n = 12284 subjects) were used to generate reference intervals for LDL-TG and to determine levels in various types of hyperlipidemia.

Results

An assay for LDL-TG has been developed by use of surfactants 1 and 2, and enzymes to measure LDL-TG directly on an automated analyzer. There was an excellent correlation between results obtained with this assay and after isolation of LDL by ultracentrifugation. When the assay was applied to serum samples from normal and hyperlipidemic subjects, median normal values were 0.09 mmol/L, with significant median elevations observed in subjects with increased LDL-C, hypertriglyceridemia, combined hyperlipidemia, and hyperchylomicronemia of 0.19, 0.18, 0.28, and 0.43 mmol/L, respectively, as compared with mean LDL-C values in these subjects of 2.25, 4.01, 2.66, 3.96, and 2.43 mmol/L, respectively.

Conclusions

We have developed an automated homogeneous assay for LDL-TG for potential use in research and clinical laboratories, and documented that the TG molar content of LDL is about 5% of its cholesterol content.
Thrombophilia: Women-Specific Reference Ranges Can Prevent Misdiagnosis in Women
Authors: Veen Caroline S B , Durian Marc F , Kruip Marieke J.H.A , Ahmadi Mustafa , Petronia Sizwe M , van Asten Sjef G , Visser Willy , de Maat Moniek P M
Published: July 2018

Background

Thrombophilia is a state where abnormalities of the hemostatic system predispose a patient to thrombosis. Some coagulation factors are generally lower in women than in men. Therefore, the use of routine reference ranges (RRRs) based on male or mixed-sex groups may be misleading in the diagnosis of thrombophilia in women. We hypothesize that this affects the analysis of thrombophilia after pregnancy complications. Therefore, the aim of our study was to investigate the effect of women-specific reference ranges (WRRs) on the interpretation of hemostatic variables in postpartum women.

Methods

Coagulant and anticoagulant variables were measured 3 months postpartum in 61 healthy women with an uncomplicated pregnancy and in 197 women who experienced preeclampsia (PE). In 55 of the healthy women, these variables were also measured at least 6 months after an uncomplicated pregnancy and used to calculate WRR.

Results

In total, 48% of healthy women had normal results when using routine reference ranges compared with 89% when using WRRs (P < 0.05). In the women with PE, there were normal results in 26% of women when using routine reference ranges compared with 66% when using WRRs (P < 0.05).

Conclusion

When using WRRs, fewer abnormalities were seen in healthy women as well as in women with a history of PE, which may prevent misdiagnosis of thrombophilia.
Method Performance of Bicarbonate and Electrolytes by Use of Duodenal Fluid for Assessment of Exocrine Pancreatic Function
Authors: Pyle-Eilola Amy , Pagan Jill , Kayatin Adam , Povse Patrick N , Rietschlin Jacqua A , Cotten Steven W
Published: July 2018

Background

Evaluation of exocrine pancreatic insufficiency is challenging for both clinicians and laboratories. Indirect pancreatic function tests such as serum trypsinogen, fecal elastase, and fecal fat measurements are moderately sensitive for diagnosis of advanced chronic pancreatitis but show reduced sensitivity and specificity for diagnosis of early disease. An alternative is the endoscopic pancreatic function test, which uses duodenal secretions after administration of IV secretin. Samples are collected at various times via the endoscopic tube and then analyzed for bicarbonate, sodium, potassium, and chloride.

Methods

Precision, linearity, method comparison, and stability studies were performed on the Beckman Coulter AU5822 chemistry analyzer with duodenal fluid. Comparison with the Vitros 4600 dry slide chemistry instrument was used to interrogate differences between methods.

Results

All assays produced a CV <2% without any measurable effects from the endoscopy fluid matrix and showed acceptable imprecision near the limit of detection (CV < 5%). All analytes showed linear dilution across the analytical measuring range. All the calculated error biases from dilutions were within 50% of the CLIA-allowable error for serum for each of the respective analytes. The calculated slopes ranged from 0.841 to 1.274 when compared to the Vitros 4600. Stability studies demonstrated that sodium, potassium, chloride, and bicarbonate remained stable after storage at −20 °C and after multiple freeze–thaw cycles. The percent change for all analytes was <5% mmol/L.

Conclusions

The AU5800 series demonstrated adequate performance for the analysis of bicarbonate in duodenal fluid and therefore can be used for assessment of exocrine pancreatic function. However, notable discrepancies were observed for sodium, potassium, and chloride between the AU5800 series and the Vitros 4600.
A Novel Approach to Estimating M-Protein Concentration: Capillary Electrophoresis Quantitative Immunosubtraction
Authors: Schroeder Lee F , Huls Forest , Williams Christopher L , Li Shih-Hon , Keren David F
Published: July 2018

Introduction

M-protein quantification is routinely performed by demarcating serum protein electrophoresis (SPE) regions. However, quantification of β-migrating M-protein is hindered by overlapping nonimmunoglobulin protein. Immunosubtraction (ISUB) on capillary electrophoresis is a method currently used qualitatively to subtract out (and therefore highlight) immunoglobulin isotypes in serum, thus reducing the masking effect of normal serum proteins. This study expands on traditional ISUB by developing a quantitative immunosubtraction (qIS) methodology.

Methods

qIS is achieved by estimating the monoclonal class-specific immunoglobulin contribution to the SPE region containing the M-protein. We conducted a recovery study by use of serial dilutions from 3 patients with β-region M-proteins (n = 22), performing SPE and ISUB on each dilution. We visualized the difference between the ISUB electrophoresis trace and the involved ISUB isotype-subtracted trace to distinguish M-protein and background polyclonal immunoglobulins, which was demarcated independently by 3 pathologists. The M-protein contribution to the β-region was calculated and applied to the β-region protein concentration producing the quantitative M-protein concentration, while minimizing contamination by nonimmunoglobulin or polyclonal immunoglobulin proteins.

Results

Using a quality target of 25% error, we determined that our analytical measurable range spanned the maximum concentration tested (0.81 g/dL) to 0.05 g/dL. Passing–Bablok regression between qIS and the expected M-protein produced a slope of 1.04 (95% CI, 0.94–1.09), r = 0.99. Total CV was 4.8% and intraclass correlation between pathologists was 0.998.

Discussion

qIS promises quantification of β-migrating M-proteins at concentrations an order of magnitude lower than traditional SPE methodology, allowing earlier detection of increasing or decreasing M-protein.
Sentiment Analysis from Facebook Comments using Automatic Coding in NVivo 11
Authors: Pudaruth Sameerchand , Moheeputh Sharmila , Permessur Narmeen , Chamroo Adeelah
Published: July 2018

The number and size of social networks have grown significantly as years have passed. With its 1.5 billion active users, Facebook is by far the most popular social networks on the planet. From kindergarten kids to grandparents to teenagers, Facebook attracts users of all ages, religions, personalities and social status. Facebook users are sharing their personal information, their lifestyle, their precious moments and their feelings online. In this paper, we download a set of comments from the page ‘Opposing Views’ from Facebook. These were then categorised into either a positive comment or a negative comment using the auto code feature in NVivo 11. Comments where no positive or negative sentiments are found are considered to be neutral. Out of 626 comments, 29.6% were found to contain positive sentiments while 62.0% were found to contain negative sentiments. The outcome of this work can be used by businesses to assess public reviews about their products. This will help them understand what is working and what is not. Thus, they can improve their products and respond to customer demands sufficiently quickly.
An extension of local mesh peak valley edge based feature descriptor for image retrieval in bio-medical images
Authors: Srivastava Varun , Purwar Ravindra
Published: July 2018

Various texture based approaches have been proposed for image indexing in bio-medical image processing and a precise description of image for indexing in bio-medical image database has always been a challenging task. In this paper, an extension of local mesh peak valley edge pattern (LMePVEP) has been proposed and its effectiveness is experimentally justified. The proposed algorithm explores the relationship of center pixel with the surrounding ones along with the relationship of pixels amongst each other in five different directions. It is then compared with the original LMePVEP as well as a directional local ternary quantized extrema pattern (DLTerQEP) based approach using two bench mark databases viz. ELCAP database for lungs and Wiki cancer data set for thyroid cancer. Further a live dataset for brain tumor is also used for experimental evaluation. The experimental results show that an average improvement of 11.16% in terms of average retrieval rate (ARR) and 5.37% in terms of average retrieval precision (ARP) is observed for proposed enhanced LMePVEP over conventional LMePVEP.
Sistema de la libertad y sistema del tiempo en la obra de Friedrich Schelling
Authors: Fernández Jorge Eduardo
Published: July 2018

Las cuestiones inherentes a la relación entre tiempo y libertad alcanzan su madurez en las obras de Hegel y Schelling. En el presente artículo atenderemos de manera particular a este último, ya que el camino abierto por sus Investigaciones sobre la esencia de la libertad humana (1809) deriva con cierta claridad en los sucesivos intentos de exposición de un sistema del tiempo en las Edades del mundo (1811, 1813, 1815) y en las Lecciones de München (1827-28). Siguiendo el desarrollo de Schelling, pues, intentaremos comprender por qué en el idealismo postkantiano la búsqueda de una filosofía del espíritu como sistema de la libertad conduce a tratar el “tiempo” ya no sólo como una intuición a priori de la sensibilidad sino como una determinación inherente al absoluto, y, en tal sentido, por qué en el pensamiento de Schelling sistema de la libertad y sistema del tiempo equivalen a la exposición del absoluto.
Dimensiones políticas de la deconstrucción
Authors: Biset Emmanuel
Published: July 2018

El artículo busca realizar un aporte en el marco del renovado interés por el pensamiento político de Jacques Derrida. El objetivo es precisar ciertas contribuciones en la discusión que Derrida tiene con la fenomenología y el estructuralismo. Para ello se muestran dos dimensiones centrales de los textos tempranos del autor para pensar la política: por una parte, al discutir una definición tradicional de filosofía, ejemplificada aquí con la fenomenología, se posibilita la construcción de otro vínculo entre filosofía y política; por otra parte, al cuestionar el formalismo inherente al estructuralismo desde nociones como juego o fuerza surge una politicidad estructural pensada como economía de la violencia. El presupuesto metodológico del cual partimos es que no necesariamente en los textos donde la política constituye un tema explícito es donde deben rastrearse sus aportes paira pensar la política. Para ello, vamos a restringir nuestra lectura a tres textos: “Introducción a El Origen de la Geometría de Husserl” (1961), “Fuerza y Significación” (1963) y “La estructura, el signo y el juego en el discurso de las ciencias humanas” (1966).
Para leer la Filosofía del Derecho de Hegel
Authors: De Zan Julio
Published: July 2018

El comienzo de la Filosofía del Derecho con el concepto de “Derecho abstracto” y la “moralidad” presenta la apariencia de una forma de tratamiento típica del individualismo metodológico de las teorías jusnaturalistas. Hegel aclara sin embargo que el plan de la exposición no refleja ni el orden genético, o temporal, ni la estructura ontológica de la cosa. La pregunta que tratará de responder este artículo es, entonces, a qué criterios responde esta problemática estructura del plan de la obra. La tesis que sostiene el autor es que las dos primeras partes de la obra se tienen que leer principalmente como una exposición crítico-negativo de las teorías vigentes, y que recién la tercera parte sobre las instituciones de la eticidad expone positivamente el pensamiento de Hegel. Pero el tratamiento del derecho y la moralidad no es tampoco meramente negativo, sino que retoma y hace suyos al mismo tiempo principios fundamentales del jusnaturalismo y de Kant, como condiciones necesarias para comprensión de las instituciones de la sociedad y del Estado modernos.
La temporalidad como estructura de L’Action (1893) de Maurice Blondel
Authors: Perkins Patricio
Published: July 2018

El trabajo analiza la estructura de L'Action (1893) del filósofo francés Maurice Blondel en tres niveles diferentes según el modelo de la configuración triádica de la temporalidad. El primer nivel está implícito en la analítica de la acción llevada a cabo en la Introduction a la obra; el segundo nivel se identifica con el análisis de la pasividad del primer momento de la cuarta parte; el tercer nivel abarca la obra considerada en su globalidad, extendiéndose a la problemática del fenómeno de la acción, de la demostración del único ser necesario y de la alternativa de la acción. El análisis pretende demostrar que las dimensiones antecedente, presente y adveniente de la temporalidad están a la base de la comprensión de esta obra blondeliana.
El marxismo en el pensamiento de Augusto Del Noce
Authors: Lasa Carlos Daniel
Published: July 2018

El presente artículo hace referencia a la importancia que Del Noce ha otorgado al marxismo en la configuración de la historia contemporánea. Para nuestro autor, la forma de la historia contemporánea está determinada por una filosofía que se ha hecho mundo, cual es la marxista. La referida filosofía ha operado una reforma epistemológica de la mismísima filosofía consistente en el pasaje de una lógica de la comprensión a una lógica de la revolución. Sin embargo, a juicio de Del Noce, en el materialismo dialéctico anida una esencial contradicción, la cual conducirá a su suicidio apenas se vea aquel cumplido. En efecto, los dos momentos del marxismo, el utópico del reino de la libertad y el político de la toma del poder, deben escindirse necesariamente, terminado el segundo por absorber al primero. De allí su suicidio y la heterogénesis de sus fines. Vanamente, dos han sido las líneas que han intentado ir más allá de Marx. Aquella que ha pretendido inverare a Marx (Giovanni Gentile) quitándole el materialismo y que ha desembocado, a través de Antonio Gramsci, en la sociedad de la opulencia; y la otra que, despojando al materialismo dialéctico de la dialéctica, ha terminado en el más absoluto relativismo, representado en las denominadas ciencias humanas y sociales.
La desalienación estética en Schiller y Marcuse
Authors: Conti Romina
Published: July 2018

El trabajo analiza la relación entre los conceptos de alienación y cosificación en torno a sus nexos con el problema de la racionalidad. La hipótesis que guía la reflexión sostiene que aquellos aspectos de la racionalidad que se identifican como suprimidos por los procesos de alienación y cosificación, persisten latentes en la experiencia estética. Desde ese punto de partida, el desarrollo se detiene en tres cuestiones fundamentales: el análisis de los principales componentes de las teorías de la alienación y la cosificación, su vínculo con el problema de la racionalidad en los términos de la primera generación de Frankfurt y las posibilidades y límites de la dimensión estética del hombre como parte integrante de la propuesta de una racionalidad “ampliada” que —desde la teoría de Marcuse— retoma conceptos centrales del pensamiento de Schiller.
Evolución de las teorías de la justicia con respecto a los derechos humanos ya formulados y a los futuros derechos
Authors: Guerra González María del Rosario
Published: July 2018

Se analizan teorías de la justicia mostrando sus posibilidades y límites; se completa el pensamiento liberal moderado con concepciones que toman en cuenta las desigualdades culturales y económicas. Se sostiene que si se desarrollara teóricamente el principio de la diferencia, junto con los principios de igualdad y libertad, se tendrían sistemas más justos. Las concepciones teóricas sobre el tema cambiaron en los últimos años, en el presente está en construcción una teoría de la justicia que desea reunir la casi universalidad inserta en el pensamiento de los derechos humanos, con el fomento de la diversidad cultural de los pueblos.
Intrascendencia del derecho
Authors: Maureira Max
Published: July 2018

Que el derecho se deduce de la moral, entendida ella en sentido amplio, es evidente en Kant, pero no en Fichte. En efecto, según este último el derecho es, más bien, una condición del despliegue de la libertad. Aquello que se realiza libremente, y que, según Fichte, en esta medida constituye la realidad, se autodispone. Por lo tanto, reclama para sí la exigencia de su concreción. Ella es, por eso, un momento de lo mismo: la génesis de la propia libertad. Con el derecho no se apela aquí, pues, a ninguna trascendencia sin más. A mostrar esta genética comprensión fichteana del derecho se consagra este trabajo.
El pesimismo histórico en la filosofía de Denis Diderot
Authors: Ratto Adrián
Published: July 2018

Los especialistas suelen atribuir a Diderot una concepción pesimista de la historia. Si bien de las obras de madurez del editor de la Encyclopédie se desprende una oscura imagen del porvenir, producto entre otras cosas de su encuentro con Catalina II y de la influencia de Galiani, ese pesimismo parece no agotar sus reflexiones acerca de la historia. De los trabajos de la época anterior a su viaje a Rusia se desprende otra concepción de la historia, la cual, no obstante, no se confunde con las Cándidas especulaciones acerca del futuro del marqués de Condorcet.
El genio secreto del catalejo (Kikkertens Hemmelighedsfulde Aand)
Authors: Rengifo Sandra , Escobar Neira Fernado
Published: July 2018

Este texto está construido sobre diversos acercamientos conceptuales y teóricos al proyecto El genio secreto del catalejo (Kikkertens Hemmelighedsfulde Aand) de la artista Sandra Rengifo. La perspectiva de análisis puesta en trabajo se aleja de discursos propios de la historia del arte y de la estética, y por el contrario, instala preguntas más cercanas a campos de conocimiento como la geografía cultural, los estudios del paisaje y los estudios visuales. El objetivo principal es describir la relación y tensiones que mantiene el proyecto artístico con respecto a espacialidades, objetos, lugares y paisajes. Con este fin, nociones relativas a la repetición y a la fragmentación propias tanto de los referentes como de las narrativas que implicó el proyecto, fueron útiles para acopiar y reordenar los indicios sugeridos por Rengifo.
Ecología en prácticas cotidianas
Authors: Garavito López Elizabeth
Published: July 2018

El presente trabajo da cuenta de un proceso que parte de las prácticas cotidianas de los participantes en el que se acude a las narrativas no verbales generadas en estos espacios, en este caso, a través de la construcción de microuniversos (pequeños relatos que se construyen con plantas y objetos dentro de una maceta). Se ha desarrollado con un grupo de personas en la Facultad de Artes –ASAB, de la Universidad Distrital Francisco José de Caldas en la ciudad de Bogotá, a partir de una serie de talleres abiertos al público, que desde de la práctica misma indagaban la potencialidad de estos escenarios como “prácticas artísticas colaborativas”.
Primavera en las galerías de arte de Shanghái
Authors: Harillo Pla Adrià
Published: July 2018

El presente artículo es una crítica artística a diferentes obras de arte y propuestas expositivas presentes en diferentes galerías de arte contemporáneo ubicadas en M50, el distrito del arte de la ciudad de Shanghái, la capital económica de China. Semejante crítica coincide con las exhibiciones en un contexto tan importante como es la primavera en China, momento del año que tiene un gran papel en la larga historia del arte en ese país. Mediante el presente artículo el autor tiene la pretensión de aproximar algunos de los artistas y obras actualmente expuestos a la comunidad latinoamericana, algo que, debido a las particularidades del país asiático, puede ser complejo en algunas ocasiones.
Mickey Mouse como símbolo de resistencia contra la contaminación cultural: una aproximación a la obra Chac Mool III de Nadín Ospina
Authors: Arias Albeiro
Published: July 2018

El presente artículo presenta algunas reflexiones teóricas sobre el uso de los medios de comunicación como articuladores ideológicos dentro de las sociedades de control (Deleuze, 1991) y la obra de arte como posibilidad de resistencia contra el poder (Deleuze, 2007), para con base en dichas posturas abordar la obra Chac Mool III (1999) del colombiano Nadín Ospina, en donde se evidencia la apropiación del artista de un icono cultural estadounidense (Mickey Mouse) para convertirlo en un contra discurso que cuestiona la contaminación cultural hegemónica.
Enlaces globales y link del antepasado: ante dos pinturas de un visionario de izquierda
Authors: Mazzoldi Bruno
Published: July 2018

Sea desde el Foro Económico Latinoamericano, sea desde los soberbios monumentos de las Luces parisinas proliferan enlaces que deberían reconciliar a los maestros verdes de la Amazonía con la modernidad de la postmodernidad y relativos avances de corte franciscano. Ante semejantes abrazos no sobra atisbar las argucias y el indómito recato de lo cotidiano emergente de las visiones de Jeisson Castillo, pintas y pinturas del golpe de sin-estado escurrido a expensas de sujetos soberanos por intercesión del compuesto farmacológico conocido como “ayawaska”, rituales de gloriosa modestia a la altura de la caza amorosa declarada a una astronave de flores, comunión de caminos irreductibles a la disyuntiva de emancipación o captura porque reacios al éxtasis que suele desdeñar la historia, si acaso sabiduría y arrugas de los pies de la Madre del Jaguar insinuados en chancletas de caucho contemporáneo, más sólidas y actuales que la sandalia escupida por el atanor de Empédocles.
Macrophage Activity Test of Pulmonary Tuberculosis Patients with Diabetes Mellitus (TB-DM)
Authors: Antari Arlita Leniseptaria , Saraswati Indah , Pakaya David , Widodo Aryoko
Published: July 2018

Background: Control of pulmonary TB is getting more and more complicated as the number of patients with diabetes mellitus (DM) is increasing. The increasing prevalence of DM is followed by the increasing prevalence of pulmonary TB. Diabetes Mellitus patients have 4,7 times higher risk to develop pulmonary TB compared to patients without DM, since DM can increase the frequency and severity of an infection, including pulmonary TB.Aim: To analyze macrophage activity (phagocytosis, intracellular killing, and TNF-α synthesis) of TB-DM patients.Method: The research is an experimental study using a PBMC cultured sample from TB-DM patient's which undergo observation of macrophage activity (phagocytic, intracellular killing and TNF-α synthesis). The data were taken from microscopic observation of TB-DM patients, colony growth of viable Mycobacterium tuberculosis and the TNF-α level secreted by macrophages.Result: Microscopic observation showed that there are less amount of phagocytosed M. tuberculosis (in macrophage/intracellular level) and there is a little amount of formed vacuoles and giant cells. Furthermore, macrophages in TB-DM patients secrete low level of TNF- α, and there are more viable M. tuberculosis from this macrophage.Conclusions: Macrophages of TB-DM patients are less activated, with reduced phagocytic activity (due to the intrinsic defect of PMN) and reduced antigen presenting activity of phagocytes toward M. tuberculosis. Therefore, there is a need for a further study focused on macrophage activity enhancement on TB-DM patients against M. tuberculosis infection in DM patients.Keywords: macrophage, TB-DM, phagocytosis, intracellular killing, TNF- α.
The Fragility of the Near-Hand Effect
Authors: Dosso Jill A. , Kingstone Alan
Published: July 2018

Recent literature has demonstrated that hand position can affect visual processing, a set of phenomena termed Near Hand Effects (NHEs). Across four studies we looked for single-hand NHEs on a large screen when participants were asked to discriminate stimuli based on size, colour, and orientation (Study 1), to detect stimuli after a manipulation of hand shaping (Study 2), to detect stimuli after the introduction of a peripheral cue (Study 3), and finally to detect stimuli after a manipulation of screen orientation (Study 4). Each study failed to find a NHE. Further examination of the pooled data using a Bayesian analysis also failed to reveal positive evidence for faster responses or larger cueing effects near a hand. These findings suggest that at least some NHEs may be surprisingly fragile, which dovetails with the recent proposition that NHEs may not form a unitary set of phenomena (Gozli & Deng, 2018). The implication is that visual processing may be less sensitive to hand position across measurement techniques than previously thought, and points to a need for well-powered, methodologically rigorous studies on this topic in the future.
Dimethyl fumarate accelerates wound healing under diabetic conditions
Authors: Li Ying , Ma Fuzhe , Li Huimin , Song Yuguo , Zhang Huan , Jiang Ziping , Wu Hao
Published: July 2018

Impaired wound healing is a common complication among patients with diabetes mellitus (DM), resulting in high rates of disability and mortality. Recent findings highlighted the critical role of nuclear factor erythroid 2-related factor 2 (NRF2) – a master of cellular antioxidants scavenging excessive DM-induced free radicals – in accelerating diabetic wound healing. Dimethyl fumarate (DMF) is a potent NRF2 activator used for the treatment of multiple sclerosis. However, the effect of DMF on wound healing has not been determined. The present study investigated the effect of DMF on the diabetic and the non-diabetic wound healing in streptozotocin-induced diabetic mice and non-diabetic control mice. DMF activated NRF2 signaling under both conditions. Interestingly, DMF attenuated oxidative damage and inflammation and accelerated wound closure in diabetic mice. However, this effect was not observed in non-diabetic mice. Keratinocytes were treated with normal glucose (NG), high glucose (HG) or hydrogen peroxide (H2O2), in the presence or absence of DMF to assess the role of reactive oxygen species (ROS) – inducible in DM – in mediating DMF-induced protection. Both HG and H2O2 elevated ROS, oxidative damage and inflammation, the effects of which were similarly blunted by DMF. However, in spite of the activation of NRF2, DMF lost this capability under the NG condition. The findings of this study demonstrate that ROS activate the protective effect of DMF on the diabetic wound healing.
Transposons and the PIWI Pathway – Genome Defence in Gametes and Embryos
Authors: Russell Stewart J , LaMarre Jonathan
Published: July 2018

Hiding in plain sight within the genome of virtually every eukaryotic organism are large numbers of sequences known as transposable elements (TEs). These sequences often comprise 50% or more of the DNA in many mammals and are transcriptionally constrained by DNA methylation and repressive chromatin marks. Individual TEs, when relieved of these epigenetic constraints, can readily move from one genomic location to another, either directly or through RNA intermediates. Demethylation and removal of repressive histone marks during epigenetic reprogramming stages of gametogenesis and embryogenesis render the genome particularly susceptible to increased TE mobilization, which has significant implications for the fidelity of genome replication and subsequent viability of the progeny. Importantly however, TEs have functionally integrated themselves into developmental events to the extent that complete suppression precludes normal gamete and embryo development. Consequently, multiple mechanisms have evolved to limit the extent of TE expression and mobilization during reprogramming without completely suppressing it. One of the most important TE repression mechanisms is the PIWI/piRNA pathway, in which 25 – 32 nucleotide RNA molecules known as piRNAs associate with Argonaute proteins from the PIWI clade to form piRISC complexes. These complexes target and silence TEs post-transcriptionally and through the induction of epigenetic changes at the loci from which they are expressed. This review will briefly discuss the intricate molecular détente between TE expression and its suppression by the PIWI pathway, with particular emphasis on mammalian species including human, bovine and murine.
Review of Things Are Different Here by Rod Michalko (2017)
Authors: Snoddon Kristin
Published: July 2018

In Michalko’s mellow writing, blind people are presented as ordinary living beings who reflect on and confront the vagaries of existence, both in ways like everybody else and in ways that are unlike anybody else. His book offers inspiration for other readers and writers seeking a non-normative plot.
Do Platelets Play Roles as An Immune Component?
Authors: Powell Christine , Alia Gwenda , Forman Nancy
Published: July 2018

Platelets are enucleate mobile fragments acknowledged for his or her important position in coagulation and vascular integrity. But, evidence is becoming more and clearer that platelets make contributions to various immunological strategies extending the past conventional view of platelets as fragmentary mediators of homeostasis and thrombosis. There may be current proof that platelets take part in: 1) intervention in opposition to microbial threats; 2) recruitment and promoting of innate effectors mobile capabilities; 3) modulating antigen presentation; and 4) enhancement of adaptive immune responses. In this way, platelets ought to be regarded as the underappreciated orchestrator of the immune system. This review will talk latest and ancient evidence regarding how platelets affect both innate and adaptive immune responses. As an instance, platelets have lately been proven to chemotaxis in response to specific stimuli and produce micro particles able to beginning each thrombosis and infection. The substantial role of platelets is a world still opens to exploration and could provide a non-stop source of amazement into the competencies of these anucleate cells.
Inequalities of various metrics for the norms $$$\|x\|_{p,\delta} = \sup \bigl\{ \| x \|_{L_p[a,b]} \colon a,b\in \mathbb{R}, b-a\leqslant \delta \bigr\}$$$ of differentiable functions on the real domain
Authors: Kofanov V.A.
Published: July 2018

We prove sharp inequalities of various metrics for the norms $$$\| x \|_{p, \delta}$$$ of differentiable functions defined on the real line, trigonometric polynomials and periodic splines.
The criterion of the best approximant for the multivariable functions in the space $$$L_{p_1,...,p_{i-1},1,p_{i+1},...,p_n}$$$
Authors: Traktyns'ka V.M. , Tkachenko M.Ye. , Osennikova D.O.
Published: July 2018

The questions of the characterization of the best approximant for the multivariable functions in the space with mixed integral metric were considered in this article. The criterion of the best approximant in space $$$L_{p_1,...,p_{i-1},1,p_{i+1},...,p_n}$$$ is obtained.
Evaluación de estrategias para la gestión integral de residuos de aparatos eléctricos y electrónicos
Authors: Redondo Johan Manuel , Ibarra Vega Danny Waldir , Monroy Liliana Maria , Bermudez Jorge Ivan
Published: July 2018

Este artículo presenta un modelo para la evaluación de estrategias en la gestión de Residuos de Aparatos Eléctricos y Electrónicos (RAEE). Estos residuos representan un riesgo para la salud pública y para el medio ambiente, por los compuestos de tipo peligroso que los constituyen y el aumento de su generación. En Colombia existe desde 2013 la ley 1672 lineamientos para la adopción de una política que mejore la gestión de los RAEE. Esta Ley propone objetivos gestión pública, de los cuales en este artículo se evaluaron tres de ellos (Reducción en la generación, incentivo al aprovechamiento, promover la participación integrada). Para esta evaluación, se construyó un modelo utilizando la metodología de Dinámica de Sistemas, la cual permitió establecer la estructura del sistema socio-ambiental de generación y manejo de los RAEE. Así mismo, fueron definidos dos escenarios de evaluación, el primero es el estado inicial o natural que corresponde al sistema sin ninguna estrategia y el segundo es el sistema con la implementación de las estrategias, las cuales se dividieron en dos grupos. Uno es Estrategias de economía circular, educación ambiental y fomento de empleo, y el otro grupo contiene las estrategias de responsabilidad extendida del productor, estímulos de la ciudadanía y tarifa de recolección. Las simulaciones del modelo y comparaciones los escenarios, mostraron que el primer grupo de estrategias disminuyeron la tasa de generación de RAEE. De igual manera, permitieron evaluar segundo grupo de estrategias sobre la tasa de disposición. De igual manera El modelo propuesto para la gestión de Residuos de Aparatos Eléctricos y Electrónicos es útil, para la evaluación de estrategias de gestión de residuos en distintos escenarios.
Methodology for determining the mean and extreme sea level regimes (astronomical and meteorological tides) considering scarce records in microtidal zones: colombian Caribbean case
Authors: Orejarena-Rondón Andrés Fernando , Otero-Díaz Luis Jesús , Restrepo L. Juan Camilo , Ramos De la Hoz Isabel María , Marriaga-Rocha Leonardo
Published: July 2018

Se calibraron y modelaron series sintéticas del nivel del mar (NM) con una extensión temporal de 20 años (1991-2010) en la Bahía de Cartagena y el Golfo de Urabá. Las series simuladas fueron ajustadas a diferentes funciones de probabilidad obteniendo los mejores ajustes con las funciones de distribución Normal y de Gumbel para los regímenes medios y extremos respectivamente. Dentro y fuera de la bahía de Cartagena no existen variaciones representativas en el régimen medio, mientras que en el Golfo de Urabá la magnitud aumenta al doble en la parte sur. Además, el régimen extremo presenta magnitudes superiores en la parte sur del Golfo en relación a las demás zonas estudiadas. Esta metodología podría implementarse en áreas donde los registros del nivel del mar son escasos o poco confiables. Por lo tanto, puede ser valiosa para planificar y construir infraestructuras portuarias y costeras, o implementar medidas de reducción de riesgos.
A Stubborn Case of Syphilitic Hepatitis
Authors: Campitelli Marco , Al Moussawi Hassan , Zeineddine Nabil , Maslak Stephen
Published: July 2018

Background

Syphilitic hepatitis is a rare occurrence, but delay in its diagnosis can expose patient to unnecessary testing. The treatment available for this condition can also vary from one intramuscular injection of Penicillin G to a 2-weeks course of intravenous penicillin.

Case presentation:

A 53 years old male, presented for fever and abdominal pain, was found on physical examination to have a macular rash on the palms and soles, with fever and abdominal tenderness.

Laboratory findings revealed AST 199 IU/L, ALT 132 IU/L, positive RPR, FTA-ABS and HIV antibodies test and a high HIV viral load.

He was diagnosed with secondary syphilis and HIV co-infection. His hepatitis did not improve after intramuscular injection of penicillin G, his symptoms continued to worsen. A liver biopsy was done and revealed acute hepatitis and canalicular cholestasis, without evidence of treponemes.

Patient was started on intravenous penicillin. He showed significant clinical improvement, and his LFT normalized.

Conclusion:

This case describes severe syphilitic hepatitis with unusual cytolytic disturbance of the liver function that failed to improve with one intramuscular penicillin injection. It demonstrates the need of intravenous penicillin therapy to achieve adequate clinical response, particularly in patients with severe laboratory evidence of liver inflammation.
To Study The Serum Vitamin –D And Oxidative Stress Status In Rheumatoid Arthritis
Authors: Uma T
Published: July 2018

Aim and objectives: Rheumatoid arthritis (RA) is a chronic autoimmune systemic disease characterized predominantly by synovial inflammation, leading to joint destruction. The study was undertaken to analyze the vitamin –D and oxidative stress status in Rheumatoid arthritis

 

Materials and methods: The Study includes Patients diagnosed as RA by using RA factor within the age group of30 to 60 years and comprised of 20 age matched control group. To assess oxidative stress, serum Malonyldialdehyde (MDA) was by thiobarbituric acid method and antioxidant level was assessed by estimation of serum vitamin C by dinitrophenyl hydrazine method. And vitamin D total is estimated by chemiluminescent immunoassay.

Results: There is a significant decreased level of vitamin -D in the RA patients (37.58±5.7ng/ml) as compared to healthy controls (58.5±5.6ngl/ml). There is a  a significant increased levels of  MDA in the RA patients (7.6±1.09) as compared to healthy controls (8.4±2.8). There is a significant decreased level of vitamin -c in the RA patients (0.6±0.3mg/dl) as compared to healthy controls (1.0±0.31mg/dl).

 

Conclusion: Low levels of Vitamin D deficiency in RA patients is associated  with inflammation which leads to Increased oxidative stress status , which may lead to connective tissue degradation leading to joint and periarticular deformities in rheumatoid arthritis.
“Public Health Hints: How To Best Breath And More Which Everyone Must Know And Use To Be Healthy!”--
Authors: Nigro Samuel A.
Published: July 2018

Simple clinical health improving procedures are offered which should be promoted by public health organizations everywhere.  These procedures are the result of discovering the cure for the author's severe laryngospasm disorder.  Discovering the SAM prompted reflections on improving simple valuable self-care for all.  All techniques are described and recommended for improving health care and comfortable living for everyone everywhere old enough to follow directions.  They have to be daily practiced and made routine.
Oferta de programação da Rede Globo de Televisão em face de audiência infantojuvenil: estudo empírico
Authors: Galhardi Claudia , Minayo Maria Cecília de Souza
Published: July 2018

Embora a contemporaneidade tenha trazido o desenvolvimento, a presença e o uso de novas plataformas de comunicação e entretenimento, no Brasil a televisão segue sendo o meio massivo mais consumido entre crianças e adolescentes. Nesse cenário, 75,4% das crianças e adolescentes reconhecem a existência de conteúdo inapropriado ao qual eles não deveriam assistir. Este artigo visa revelar o atual quadro de oferta de programas destinados ao público infantojuvenil da emissora de maior audiência no país, a Rede Globo, uma rede de televisão comercial aberta brasileira com sede na cidade do Rio de Janeiro. Trata-se de um estudo empírico quantitativo, realizado a partir da técnica de análise de conteúdo da programação veiculada no período de março de 2016. Os resultados indicam uma escassa veiculação de conteúdos adequados ao público infantojuvenil.
Práticas colaborativas nas urgências em Saúde: a interprofissionalidade do Programa PermanecerSUS, Secretaria Estadual de Saúde da Bahia, Brasil
Authors: Figueredo Wilton Nascimento , Veras Renata Meira , Silva Gilberto Tadeu Reis da , Cardoso Gustavo Marques Porto
Published: July 2018

Este artigo apresenta e discute o Programa PermanecerSUS como uma proposta de educação interprofissional (EIP) à formação em Saúde. Possui abordagem qualitativa, sob a perspectiva da Etnografia Institucional (EI). A discussão se respalda no conteúdo registrado no diário de campo construído pelo pesquisador-etnógrafo durante a observação participante em duas unidades de urgência hospitalar, na cidade de Salvador, Bahia, Brasil. Os resultados sugerem que o programa desenvolve competências como o trabalho em equipe, a intercomunicação e a solução de problemas em conjunto entre os estudantes; e proporciona integração educação e trabalho. Entretanto, os desafios do PermanecerSUS estão pautados em proporcionar melhorias na relação comunicacional entre os estagiários e profissionais do serviço e investir na formação dos preceptores do estágio, com perspectivas de mudanças das práticas e impactos à qualidade da assistência nos serviços de saúde.
A produção científica sobre docência no ensino superior: uma análise bibliométrica da SciELO Brasil
Authors: Cintra Paulo Roberto
Published: July 2018

A maioria das políticas públicas brasileiras sempre tiveram como foco a pesquisa científica, dando pouca importância às práticas pedagógicas. Por esse motivo, o objetivo deste artigo é analisar a produção científica acerca da docência no Ensino Superior. Para tanto, foram construídos indicadores bibliométricos, elaborados a partir de uma coleta de dados na base da SciELO Brasil. Os resultados apontaram para uma tendência ascendente no número de publicações versando sobre o assunto analisado. As principais temáticas dessa produção foram a respeito das práticas didáticas, sistemas de avaliação e saúde do docente. Verificou-se que alguns dos periódicos que mais publicaram artigos sobre o assunto não são da área da Educação, mas de outros campos científicos como Química, Medicina e Enfermagem. Conclui-se que a crescente importância da discussão dentro da comunidade científica demonstra que as políticas públicas deveriam se adequar às necessidades do Ensino Superior, de modo que a formação didática do futuro professor também seja uma prioridade.
A new adaptive thermal comfort model for the Romanian climate
Authors: Udrea Ioana , Croitoru Cristiana , Nastase Ilinca , Crutescu Ruxandra , Badescu Viorel
Published: July 2018

Adaptive thermal comfort refers to the ability that the occupants of a building have to accustom themselves to specific thermal conditions. The notion of human thermal comfort (HTC) is therefore introduced and defined by a simple mathematical equation. In the evaluation process of actual buildings and in the design of new ones, adaptive HTC equations translate into a substantial reduction in energy consumption and maintenance costs to the buildings. Specialised databases provide adaptive HTC equations that are regarded as standard over large geographical areas. However, in particular climate regions, new adaptive HTC equations have to be established. This paper aims to find an HTC equation specific to the Romanian climate (Köppen climate type D – temperate continental climate). In order to achieve that, a field survey was conducted between 2013 and 2014 in several naturally ventilated buildings (two university buildings from Bucharest, a passive office building and a residential house). The input data consist of questionnaire surveys as well as measurements of comfort parameters.
Modelling ventilation system operation in order to reduce natural radiation in buildings
Authors: Božilović Zvonimir
Published: July 2018

Over 70% of the total annual radiation dose received by the human population comes from natural sources of radiation; 40% of that quantity is due to the presence of the natural radioactive gas, radon. Its most common and most significant isotope is radon-222 (222Rn). Indoor radiation activity occurs due to radon migration from soil and due to other radioactive substances present in building materials. The most important factor that influences indoor radiation activity concentration is ventilation. It is very important to optimise the concentration of indoor radiation activity and ventilation system intensity for human health, environment and energy saving, because earlier studies paid scant attention to the issue of radon concentration decrease by ventilation. The software Resrad-Build is used to simulate exposure to radiation of persons working or living in a building contaminated with radioactive material, in the case of a typical basement and a room above the basement. The model evaluated the maximum length of time between two automatic activations of the ventilation system and the minimum value of the permanent ventilation intensity needed to make the average annual received radiation dose for the person less than 1 mSv.
Mural As A Revolt To The Uniform Development Of Cities: The Case Of Istanbul
Authors: Zeybek Osman
Published: July 2018

Today,
structures and public open spaces, especially in the cities of our country,
show a lack of identity. The living spaces that we use on a day-to-day basis
are becoming increasingly monotonous and ordinary as a result of trying to be
less costly due to capitalism and not allocating sufficient budget for the
design and maintenance of public spaces. One of the most creative initiatives
to destroy this boring homogeneity has been shaped in murals, in the absence of
differences, the unification of space definitions, the construction of cheap
materials, the diminishing, unidentified and shrinking green spaces. It is
possible that these paintings, which are drawn on huge scale on the blind walls
of various structures of the city, gradually turn into a landmark. Festivals
have even begun to be organized in Istanbul for murals that have indisputably
increased spatial awareness in the modern urban landscape, although the
appropriateness of Istanbul's identity is discussed. In the scope of the study,
Istanbul's murals were investigated, their locations were marked on the map,
and the areas where they are concentrated were researched and their
contributions to the city identity were examined.
Extending property on EC-Fully Submodules
Authors: YAŞAR Ramazan , TERCAN Adnan
Published: July 2018

There
are several generalizations of -modules
in literature. One of the generalization is based on fully invariant
submodules. Recall that a
module  is called -extending
if every fully invariant submodule is essential in a direct summand. We call a module
-extending
if every fully invariant submodule which contains essentially a cyclic
submodule is essential in a direct summand. Initially we obtain basic
properties in the general module setting. For example, a direct sum of -extending
modules is -extending.
Again, like the -extending
property, the -extending
property is shown to carry over to matrix rings.