bluuebunny/crossref_metadata_2025 huggingface dataset:
A clinical evaluation of low-level laser therapy for pain reduction in early treatment stages: A pilot study
Authors: Akash Lavate Priyanka , Kamble Pallavi , Agrawal Jiwanasha Manish , Vijapure Shashank , Alansari Reem Ahmed , Uzunçıbuk Hande , Marrapodi Maria Maddalena , Cicciù Marco , Minervini Giuseppe
Published: May 2024

Objectives:

This study aimed to clinically evaluate the efficacy of low-level laser therapy (LLLT) in reducing pain associated with orthodontic movement during the early stages of treatment.

Material and Methods:

A randomized controlled trial was conducted with 20 participants undergoing non-extraction orthodontic treatment. The laser group (LG,n= 10) received LLLT (808 nm, 100 mW) immediately after appliance installation, while the control group (CG,n= 10) received no pain control intervention. Pain levels were assessed using a visual analog scale (VAS) at 6, 24, 48, and 72 h till 7 days with an interval of 24 h. Statistical analyses included Chi-square tests and Mann–Whitney tests.

Results:

The LG consistently demonstrated significantly lower pain scores during chewing and at rest compared to the CG. After 6 h post-treatment, the median pain score on chewing in the LG was markedly lower than the CG (P< 0.001), a trend observed at each subsequent interval till 7 days. The comparison of spontaneous pain also favored the LG at various time points. Lower median VAS scores for pain on chewing among the LG and CG were zero and two, respectively, with a significant difference. The maximum median VAS scores for pain on chewing among the LG and CG were five and seven, respectively, with a significant difference.

Conclusion:

This study provides robust evidence supporting the effectiveness of LLLT in reducing orthodontic pain during the early stages of treatment. The sustained and significant reduction in pain scores, coupled with rigorous statistical analyses, emphasizes the potential of LLLT as a valuable adjunctive therapy in orthodontic practice.
Is endoscopic third ventriculostomy a viable treatment option for normal pressure hydrocephalus? A systematic review
Authors: Sohail Ayesha , Bajwa Mohammad Hamza , Virani Qurat-Ul-Ain , Tariq Anam , Hussain Nasr , Shamim Shahzad M.
Published: May 2024

Background:

Endoscopic third ventriculostomy (ETV) is considered an alternative treatment for hydrocephalus and has become a standard of care for obstructive hydrocephalus. Recent studies have also explored its role in normal pressure hydrocephalus (NPH). We conducted a systematic review aiming to assess the outcomes of this minimally invasive endoscopic technique as a viable treatment option for NPH.

Methods:

A systematic literature search was performed using PubMed and Scopus databases, using iterations of search terms “Endoscopic third ventriculostomy,” “Idiopathic normal pressure hydrocephalus,” and “Normal pressure hydrocephalus.” To be eligible for inclusion in the review, articles had to report the usage of ETV as a primary treatment modality for NPH, report its outcomes, and be published in the English language.

Results:

Out of the 13 studies selected for qualitative synthesis, nine supported the use of ETV for NPH as an effective treatment option with improvement in the preoperative symptoms. Two studies favored shunt over ETV, stating that quality of life is better with VP shunt insertion. One study reported that ETV has higher perioperative mortality rates that outweigh its benefits. One study reported it to be an ineffective surgical option.

Conclusion:

The current review of evidence does not support the use of ETV for the treatment of NPH, except perhaps in a small subset of patients. These patients have a shorter duration of symptoms and a better preoperative neurological status. The lumbar infusion test and ventricular infusion test are modalities useful for selecting these candidates.
Crestal Bone Remodeling in Polished Collar Implants
Authors:   University of Health Sciences, Lahore, Ahsen Muhammad Iftikhar Ahsen , Haseeb Muhammad , Javed Sittara , Naqvi Zainab , Yousaf Ali Muhammad , Khan Zubair Ahmed
Published: May 2024

OBJECTIVE: This study aimed to evaluate the amount of crestal bone remodeling in polished collar implants. METHODOLOGY: Thirty patients with a missing maxillary or mandibular 1st or 2nd premolar tooth requiring simultaneous bone grafting were recruited and implant placed at the level of crest with polished collar placed 1mm apical to the level of bone and bone augmentation was performed to graft the buccal threads. Buccal bone thickness was measure at crestal level as well as 1mm apical to polished collar. The implants were uncovered at 6 months and restored and patients followed up for 12 months from the time of implant placement. Cone beam computed tomography scans were taken at two time points, immediately after implant placement and at 12-month time point. RESULTS: At clinical re-entry (6 months), there was significant difference in mean buccal bone thickness found between crestal level and 1mm apical to polished collar (p<0.05). Radiographically (at 12 months), the mean buccal bone change was -1.82mm 0.57mm at crest and -0.94mm 0.31mm at 1mm apical to crest. CONCLUSION: Bone regenerative techniques were unable to prevent biologic bone remodeling around the implant platform; therefore, the outcomes of bone augmentation might be affected by the polished collar of implant. KEY WORDS: Dental implants, polished collar, bone augmentation, bone remodeling, cone beam computed tomography
Parental Acceptance and Attitudes Towards Various Behavior Management techniques for Children During Dental Treatment: A Cross-Sectional Study
Authors:   Fatima Memorial Hospital  College of Medicine and Dentistry, Lahore., Babar Palwasha , Qaiser Uswa , Zalan Abul Kher , Qazi Halima Sadia , Haider Irsam , Virda Maryam
Published: May 2024

OBJECTIVE: To evaluate the parental perceptions and attitudes towards different behavior management techniques commonly employed by dentists. METHODOLOGY: A cross-sectional descriptive study was conducted using a self-structured questionnaire. Data was collected from 134 parents accompanying their children (aged 5-10 years) for dental treatment. Descriptive and inferential analyses were carried out using SPSS v21. RESULTS: Among the 134 parents, 41.7% were males and 58.3% were females. The mean age of the children included in the study was 6.67 (SD+ 0.92) of which 44.02% were males and 55.9% were females. In addressing non-cooperation during dental procedures 30.1% of the parents would opt to defer the treatment and 24.4% expressed a preference for the dentist to perform the procedure forcefully. A majority of 86.5% expressed the desire to accompany their child during the dental treatment.The most acceptable technique by the parents was Tell-Show-Do and live modeling followed by positive reinforcement while treatment under general anesthesia was the least acceptable. CONCLUSION: Parents prefer using less aggressive techniques like Tell-Show-Do, modeling and positive reinforcement for the management of their children and the majority want to accompany the child during the treatment. The parents' least accepted technique is treatment under general anesthesia. A thorough understanding of parental desires promotes a healthy dentist-parent relationship. KEYWORDS: Behavior therapy, Parental consent, Dentist-patient relationship, Pediatric Dentistry, Behavior management techniques
Evaluation of Awareness and Preparedness for Medical Emergencies among Dental Practitioners in Twin Cities of Punjab: A Cross-sectional Study
Authors:   Dental College HITEC Institute of Medical Sciences, Taxila Cantt, Pakistan, Khattak Fatima , Syed Zuhair Mehdi Syed Zuhair , Mehmood Arooba , Amer Wajeeha , Murtaza Kanza , Iftekhar Alishba
Published: May 2024

OBJECTIVE: The purpose of this study was to evaluate the awareness of medical emergencies among dental practitioners, to assess the degree of expertise and readiness of dental professionals to handle medical crises in their dental practices and to ascertain if medical emergency medications are offered in dental offices. METHODOLOGY: A prospective study including 208 practitioners were given access to the survey through Google Form, along with information on the study and a consent form .The questionnaire consisted of demographic details, years of experience, and specialty of practitioners and 20 closed-ended questions with 10 assessing knowledge and rest evaluating the competence and preparedness to handle medical emergencies. An emergency whether medical or dental is a serious, acute, and unexpected event that requires a quick and timely intervention. Since some diseases and their treatments increase the likelihood of a medical emergency during dental treatment. The most often encountered medical emergencies in a dental office are vasovagal syncope, angina pectoris, hypoglycemia, and hypertensive crisis. One of the mainstays of prevention of medical emergencies is by taking a thorough and detailed history, and vital signs monitoring and modifying the treatment plan. RESULTS: A response rate of 96% was achieved by including all 200 of the study’s 450 dental professionals. Just 69% of the participants had emergency kits on hand, even though roughly 77.5% of the dentists in the study felt confident in their ability to handle emergencies in the dental office. CONCLUSION: In this study, dental professionals demonstrated a moderate level of understanding in medical situations, and many of them have low to moderate perceived competency in managing medical emergencies. Every dental clinic should have well-communicated emergency protocols in place that should be updated periodically. KEYWORDS: Medical emergency, Dental Practitioner, Emergency kit, BLS, Dental Clinics
Predictive Role of Oral Biomarkers and Periodontal Status in Gestational Diabetes Mellitus: A Review of Literature
Authors:   Baqai Dental College, Baqai Medical University, Karachi, Pakistan., Wali Aisha , Akram Saadia , Asaad Maaz
Published: May 2024

Gestational Diabetes Mellitus (GDM) is a type of diabetes that occurs during pregnancy in women who did not previously have diabetes. It is characterized by high blood sugar levels that develop during pregnancy and typically resolve after childbirth. GDM occurs when the body is unable to produce enough insulin to meet the increased demand during pregnancy or when the body becomes resistant to the action of insulin. It can have significant implications for both the mother and the baby if not managed properly.In Pakistan, GDM prevalence is reported to be from 4 to 10%. While Asian countries report a wide range from 1.2 to 49.5%, largely accounting for differences in diagnostic criteria, sample size, and population source. KEYWORDS: gestational diabetes, pregnant women, biomarkers, prevalence
A comprehensive review on the synthesis of mangiferin derivatives and their multiple biological activities
Authors: Turkar Milendra Kumar , Sahu Rishika , Jain Deepti
Published: May 2024

Mangiferin, a chemically, oxygen and hydroxyl containing heterocycle and biologically versatile nucleus, has drawn more attention from traditional to modern medicinal chemists in the drug design and synthesis of novel drugs with their pharmacological properties, including anticancer, anti-inflammatory, neuroprotective, antidiabetic, analgesic, antimalarial, anticonvulsant, laxative, cardiotonic, hemopoietic, antioxidant, antimicrobial, antipsychotic, anticoagulant, and antihypertensive properties. This review basically focuses on a detailed and updated overview of mangiferin derivatives, and their diverse biological activities, with examples from both patented and non-patented literature.
Electrolytic Recovery of Metals from Lithium Battery Cathodes in Moisture-Tolerant Molten Hydroxide Salt
Authors: Lichtenstein Timothy , Gesualdi Jarrod , Stariha Sarah , Moore Colin
Published: May 2024

Mixed metal oxides in the form of lithium-ion cathode materials of LiNi0.6Mn0.2Co0.2O2 and spent lithium-ion battery materials (black mass) were electrochemically reduced to a soluble form and dissolved into a molten hydroxide salt bath. A separate cathode was used to produce alloys of Ni, Mn, and Co electrochemically from the dissolved lithium-ion cathode materials. This approach represents a scalable, carbon-free, low temperature pyroelectrochemical process that can potentially reduce the cost and close the loop of battery cathode recycling.
Positional information-based morphogenesis of surfactant droplet swarms emerging from competition between local and global Marangoni effects.
Authors: de Visser Pieter , Neeleman Mink , Dankloff Pim , Derks Max , Korevaar Peter
Published: May 2024

Positional information is proposed as a key element in morphogenesis, where cells differentiate based on their position in an external morphogen gradient. Here, we demonstrate the position-dependent differentiation of floating surfactant droplets as they self-organize in a pH gradient, using the Marangoni effect to translate gradients of surface-active molecules into motion. We start with a field of surfactant microliter-droplets floating on water, that upon the release of surfactant drive local, outbound Marangoni flows and myelin filament growth. Next, we introduce a competing surfactant based on a hydrolysable amide, which is more surface active than the myelin surfactant and thereby inhibits the local Marangoni flows and myelin growth from the droplets. Upon introducing a pH gradient, the amide surfactant hydrolyses in the acidic region, so that the local Marangoni flows and myelin growth are reestablished. The resulting combination of local and global surface tension gradients produces a region of myelin-growing droplets and a region where myelin-growth is suppressed, separated by a wave front of closely packed droplets – featuring an organization that is reminiscent to the ‘French flag’-patterns emerging from concentration gradients in morphogenesis.
Dual Ligand Enabled Pd-Catalyzed Ortho-Alkylation of Iodoarenes
Authors: Wang Xiao-Xia , Jiao Lei
Published: May 2024

The synthesis of complex polysubstituted aromatic molecules from simple precursors is a central goal in organic chemistry. In this study, we developed an approach for the ortho-alkylation of iodoarenes utilizing a dual ligand catalytic system. By combining Pd/olefin ligand cooperative catalysis with bulky trialkylphosphine ligand-promoted C(sp2)-I reductive elimination, we have established an ortho-alkylative Catellani-type reaction with the aryl-iodine bond reconstruction as the final step, which opens new synthetic opportunities within the Catellani-type reactions. Through in-depth mechanistic investigations, we have isolated and characterized key organopalladium intermediates, revealing the synergistic interaction of the dual ligands in merging the Catellani-type process with C(sp2)-I reductive elimination. The present study showcases the unique advantages of Pd/olefin ligand catalysis and emphasizes the effectiveness of the dual ligand system in expanding the chemical space of the Catellani chemistry.
1H-NMR Resonance Guided Discovery of Novel Bioactive Compounds from Species of the Genus Piper
Authors: Oliviera Jr. Celso , Burroughs Megan , Richards Lora , Dyer Lee , Urbano-Muñoz Federico , Lee Camryn , Warner Megan , Wallace Ian , Dodson Craig , Jeffrey Christopher
Published: May 2024

The discovery of bioactive natural products is hindered by bottlenecks encountered during the isolation, characterization, and confirmation of the active compounds. We have applied a weighted gene correlation network analysis (WCGNA) to identify groups of 1H resonances associated with bioactivity directly from crude 1H NMR spectra of metabolites extracted from various Piper species from Costa Rica. Our screening of 30 methanolic leaf extracts against S. cereviseae revealed that three Piper species produce compounds that exhibit prominent antifungal activity. By incorporating known structural motifs into the 1H NMR networks of crude extracts, we could approximate general structural types of some of the bioactive compounds during the initial phases of this targeted approach. Using unique resonances that correlated with antifungal activity, we isolated and characterized four novel compounds, three of which were identified as the active antifungal components of the mixtures. Subsequent growth inhibition assays with purified or synthetic compounds validated their efficacy, demonstrating the potential of this approach. Overall, this method reduces the need for repeated biological assessments of fractions in a traditional bioassay-guided isolation, making it a streamlined approach to identify bioactive natural products that can be used in a variety of applications.
ڕۆلێ کوردان د بزاڤ و کۆدەتایێن سەربازیدا دژی دەستهەڵاتا مەمالیکان (٦٤٨-٩٢٣ک/١٢٥٠-١٥١٧ز)
Authors: احمد دلمان , سليم لولاف
Published: May 2024

ماوەیێ ڤەکولینێ ب سەردەمەکی گرنگ ژ مێژوویا ئیسلامێ دهێتە هژمارتن، ژبەرکو دەولەتا مەمالیکان ب سەرکێشیا جیهانا ئیسلامی دهاتە نیاسین، وەک یادیار ئەڤ ماوە یێ بێبەهر نەبوو ژ بزاڤ و کودەتایێن سەربازی دژی دەستهەلاتا وان. کوردان و ب تایبەت ئەیوبیان پلە و پایەکا مەزن د سەردەمێ بەرى دەسەلاتا مەمالیکاندا هەبوو، ل سەردەمێ مەمالیکان ژی کوردان جهێ خۆ دناڤ دەولەتێدا گرت بەلێ بشێوەیەکی کێمتر، دیسان پشکداری د رویدانێن سیاسیێن وی سەردەمی کرن، هەتا هندەک جاران دبیتە تەوەرێ سەرەکی، گەلەک دەمان پشکداری د هە ڤرکیێن ناڤخۆیی د ناڤبەرا مەمالیکاندا دکر و بزاڤدکر دەستهەلاتێ ژ دەستێ وان بیننە دەر وجارەک دی دەستهەلاتا ئەیوبیا بزڤرینەڤە، چونکە بەردەوام دیتنا وان بۆ مەمالیکان ئەوبوویە کو دەست ب سەر مولکێ واندا گرتیە و دڤێت ئەڤ مولکە بۆ خودانێت وێ یێن راستەقینە بزڤریتەڤە.
دور التنمية السياحية المستدامة في زيادة معدلات التشغيل
Authors: سليمان سارة , محمد ريبر
Published: May 2024

تهدف الدراسة الى قياس أثر التنمية السياحية المستدامة في معدلات التشغيل لعدد من الدول السياحية المختارة وهي (السويد، سويسرا، فرنسا، نمسا، ايطاليا، اليونان ، المانيا، واسبانيا) وللمدة 1995-2021، ولغرض التعرف على أثر التنمية السياحية المستدامة في التشغيل في الدول المختارة، إعتمدت الدراسة لسلوب كمي وهو أنموذج الانحدار الذاتي للإبطائات الموزعة لمعطيات البانل  (PNEL_ ARDEL, PMG)، وذلك لتقدير معلمات النموذج للمديين  القصير والطويل، وأظهرت نتائج الدراسة أنه لايوجد تاثير معنوي ذو الدلالة الاحصائية  بين معدلات التشغيل، والمتغيرات المفسرة له في المدى القصير،  أما في المدى الطويل ، فقد أظهرت النتائج علاقة ايجابية ذات تأثير معنوي بين معدل التشغيل وكلا من الاستثمار الأجنبي المباشر، والإنفاق العام على التعليم، ومعدل نمو الصناعة، و معدل نمو الايرادات السياحية، في دول عينة الدراسة خلال المدى الذي غطته الدراسة. وبالنسبة للمتغيرات التي أثرت بشكل سلبي،  فهي معدلات التضخم، وأما معدل النمو السكاني فكان له أثر سلبي ولكن غير معنوي. وتوصلت الدراسة الى عدة مقترحات من بينها: أن التنمية السياحية تتطلب التركيز على إستدامة المنشآت السياحية الموجودة بدلا من التركيز على زيادة عدد السياح، وإن التنمية السياحية المستدامة هي الخيار الأمثل لتحقيق التنمية الاقتصادية والإجتماعية في بلدان عينة الدراسة.
Tributação das pessoas jurídicas: Comentários ao Regulamento do Imposto de Renda/94, atualizados para 1997
Authors: Maia Mary Elbe Gomes Queiroz
Published: May 2024

Apesar da importância que o Imposto sobre a Renda exerce como um dos tributos de grande repercussão polí tico-social e que propicia uma das maiores arrecadações, são escassas as fontes de pesquisa existentes sobre o mesmo, o que dificulta o adequado exercício das atividades profissionais que a ele estão diretamente vinculadas, haja vista a complexidade das formas de tributação e as constantes e sucessivas alterações da legislação fiscal. Visando mostrar os conceitos básicos e possibilitar uma reciclagem e atualização da matéria, foi elaborado este livro, com base em estudos, pesquisas e na experiência pessoal adquirida pela autora ao longo dos anos, o qual tem como objetivo tornar acessível e expor, de maneira simples, o que constituiu, na prática, a legislação do Imposto sobre a Renda / Pessoa Jurídica, por meio de comentários aos artigos do Regulamento do Imposto de Renda 1994, tendo sido feitas as devidas atualizações com todas as normas editadas posteriormente à data do início de sua vigência. Procurou-se dar uma visão geral da tributação das pessoas jurídicas — fatos geradores, 1990 a 1997, com a reunião da legislação vigente nos respectivos períodos até a edição das leis nos 9.317/96 e 9.430/96, aplicáveis a partir de 01°/01/97.
Retorno a Ferraz: histórias de um pioneiro
Authors: Martins Edison N.
Published: May 2024

No início da década de 1960, doze países reunidos em Washington elaboraram um importante instrumento jurídico para o continente austral — o Tratado da Antártica. Em 1975, o Brasil aderiu ao tratado e, em 1984, o Navio de Apoio Oceanográfico Barão de Teffé partiu rumo ao sul do planeta, levando a infra-estrutura necessária para fincar, definitivamente, a presença brasileira em solo antártico. Este livro é a narrativa daquela aventura. Ê a história dos pioneiros que, como precursores, enfrentaram situações que as equipes de hoje não necessitam mais passar. Eles cumpriram sua missão com o anátema dos pioneiros — desbravaram...
A repetição em narrativas de adolescentes : do oral ao escrito
Authors: Silva Denize Elena Garcia da
Published: May 2024

Este livro mostra com clareza por que se admite hoje como fato normal a repetição de sons, itens lexicais, estruturas sintáticas e enunciados no discurso oral e derruba o equívoco das gramáticas de nosso ensino escolar que insistem em resistir à presença da repetição na escrita. Uma resistência comprovadamente infundada, já que também a escrita se serve da repetição como estratégia de textualização em grau próximo ao da oralidade. Nas palavras da Autora, “embora o ato de repetir tenha suas raízes mergulhadas na oralidade”, as análises qualitativas e quantitativas evidenciaram que, tanto para o português como para o espanhol falado e escrito, pode-se “colocar em julgamento a afirmação corrente na literatura lingüística de que a repetição é um traço central da oralidade". Mesmo fazendo um recorte nítido em seus materiais de análise, ao se restringir a textos narrativos e, dentro destes, enfocar em especial o caso dos enunciados avaliativos, as observações e as análises realizadas são riquíssimas e estimulantes a todos os interessados no funcionamento do discurso oral e escrito. A partir das poucas observações aqui trazidas, não me restam dúvidas de que esta obra deverá servir de estímulo e inspiração a professores, pesquisadores e estudantes em suas atividades no tratamento de questões da língua, cumprindo-se, assim, um dos propósitos da Autora, quando lembra que “o objetivo central deste livro terá sido alcançado se o que foi discutido aqui contribuir para uma nova postura, sobretudo no trabalho da escola com a língua materna". Luiz Antônio Marcuschi
Kinetic biopharmaceutical studies of a new paracetamol–glucosamine analgetic drug
Authors: Vashchenko O. V. , Ruban O. A. , Zupanets I. V. , Vashchenko P. V. , Ivaniuk O. I.
Published: May 2024

Background: Intercomponent drug interactions could play important role for drug release, membrane permeability and membranotropic action. Therefore, newly developed drugs need for checking their biopharmaceutical characteristics. A new analgetic drug based on paracetamol (Actimask® Acetaminoprofen) and a hepatoprotector N-acetyl-D-glucosamine has been developed, with increased safety and potentiation of the analgesic effect (Ruban O., 2022). Multibilayer lipid membranes were chosen as promising testing medium due to their proved appropriation and sensitivity for study multi-compound drug-membrane interactions. It is the basis for a kinetic approach allowing elucidation of biopharmaceutical interactions in model membrane medium.

Objectives: Revealing changes of paracetamol release and membrane penetration in the new paracetamol-glucosamine analgetic drug as well as estimation the rationale of the approach developed to trace biopharmaceutical interactions in model membrane medium.

Materials and Methods: L-a-dimyristoyl phosphatidylcholine (DMPC) multibilayer membrane was used as a model biomimetic testing medium. Differential scanning calorimetry (DSC) was applicated to trace kinetics of drug-membrane interactions.

Results: Gelatin as a part of Actimask® increased the characteristic time of paracetamol diffusion about threefold, but it had no pronounced effect on the equilibrium paracetamol penetration into the membrane. Sole glucosamine manifested no membranotropic effect under the experimental conditions, however, in combination with gelatin, it sufficiently reduced equilibrium paracetamol penetration while paracetamol diffusion remained within the experimental error. The full drug formulation increased membrantoropic effect by 34 % in compared with sole paracetamol.

Conclusions: Glucosamine and gelatin can affect both kinetic and equilibrium parameters of paracetamol-membrane interactions, while the full set of the drug components is able to increase the effect which correlates well with the previously established enhancement of analgetic effect of the drugs. The approach developed allows accurate tracing of drug release and membrane penetration depending on a set of drug components. Generally, the results obtained prove the rationale of applying the approach to pre-clinical drug examination.
Features of the state of extraembryonic structures in miscarriage early terms of pregnancy
Authors: Kravchenko E.V.
Published: May 2024

Background. Despite the modern achievements of medicine, miscarriage remains the main problem of obstetrics and gynecology science and practice. Purpose – to assess the features of the state of extraembryonic structures in case of miscarriage in the early stages of gestation. Materials and Methods. Under observation were 32 patients (main group) with a verified threat of pregnancy termination with bleeding in the embryonic period of gestation (up to 10 weeks) and 20 women (control group) with a physiological course of early pregnancy. The exclusion criteria from the study were patients with induced pregnancy, multiple pregnancies, anomalies of the development of female genital organs. All patients underwent a standard clinical and laboratory examination. During the ultrasound examination, both the state of the embryo and the state of extraembryonic structures were evaluated: the volume of the fertilized egg (V f/e), the average internal diameter of the yolk sac, the nature of vascularization of the corpus luteum, the state of hemodynamics in the myometrium. During transvaginal ultrasound, the chorionic volume (Vc) was calculated and its vascularization index (VI) was evaluated using a special three-dimensional VOCAL program. Results. Analysis of embryo biometrics in the studied groups did not reveal any significant difference. When assessing the state of extra-embryonic structures, we found that the volume of the fertilized egg and the average internal diameter of the yolk sac in women with miscarriage in the embryonic period of gestation was significantly lower. The volume of the corpus luteum of the ovary in the main group was equal to 3.0±0.3 cm3 in the control group – 5.3±0.61 cm3 , (p < 0.05). Vascularization of the corpus luteum in patients with bleeding in early pregnancy was also reduced. In patients with threatened termination of pregnancy with bleeding, Vc was 32.5±2.08 cm3 in control 71.6±2.4 cm3 . The vascularization index of the chorion in pregnant women of the main group was equal to 9.5±1.2, while in women with a physiological course of gestation it was 19.1±1.7 (p<0.05).

When evaluating the hemodynamics in the myometrium, it was also established that the resistance index in the uterine and spiral arteries in the patients of the main group was significantly higher compared to the pregnant women of the control group.

Conclusions.

When there is a threat of pregnancy termination with bleeding in the embryonic period of intrauterine development of the child, significant changes occur in extraembryonic structures.

A decrease in the volume of the fertilized egg, the average internal diameter of the yolk sac, blood flow disorders in the corpus luteum and myometrium, a decrease in vascularization of the chorion and its hypoplasia create a high risk of developing placental dysfunction and worsen the prognosis of pregnancy.
Results of mental health screening of children who were forced to leave Ukraine in 2022
Authors: Shlieienkova H.O. , Kulyk S.А. , Shevchenko N.S. , Cherkashyn M.M. , Golovina O.V. , Nosova O.M.
Published: May 2024

Background. As a result of Russian aggression, many citizens of Ukraine are forced to migrate to safe countries. Since the beginning of the war, more than 17 million people have left Ukraine. During the war, the population is exposed to a constant stress factor that is not homogeneous. For some people, this is due to being in the war zone, exposure to shelling, and staying in shelters. For others, it is caused by forced migration, separation from family, and difficult adaptation to a new social environment. The most vulnerable category is children and adolescents. Among children and adolescents who are forced to seek refuge in foreign countries, the most common post-traumatic stress disorder (PTSD). Purpose – analysis of the mental state and risk of PTSD in children and adolescents who were forced to leave Ukraine during the war. Materials and Methods. We studied 50 children aged 8 to 17 years (mean age: 11.2±2.4) who had left for European countries after the outbreak of the armed conflict in Ukraine. Results. The median total score of the PTSST was 19 points [QR 15; 23]; 42.0±6.9% of respondents were at high risk of developing post-traumatic stress disorder (PTSST score ≥ 21); 44.0±7.1% of children had an average risk of developing PTSD (PTSST from 10 to 20), 14.0±4.9% had a low level of traumatic childhood stress (PTSST ≤ 10). Thus, 86% of children had significant psychological manifestations that will require specialist consultation and qualified assistance. When analysing the degree of childhood traumatic stress depending on the child’s age, it was found that children aged 7–10 years were significantly more at risk of developing PTSD, which highlights the vulnerability of this period of life. Conclusions. According to the survey, children undergo significant changes in their mental state, even when they travel abroad and stay in safe conditions. Children aged 7 to 10 were the most sensitive to the impact of stress factors and the risk of developing PTSD. The interdependence of parental influence and the state of children’s mental health, which was determined by the educational level of parents, was established.
Marketing Communication Strategy in Tourism Development based on Local Wisdom of Jayapura City Communities
Authors: Sulistiani Indah , Syarifuddin Syarifuddin
Published: May 2024

Introduction: Based on a two-way communication model, effective communication between stakeholders can foster citizen participation in tourism management. Jayapura City's coastal tourism potential must be professionally managed, as evidenced by limited facilities and ineffective promotional strategies. The study aims to examine the community's social, economic, and cultural characteristics and devise an effective marketing communication strategy for developing coastal tourism in Jayapura City.

Methods: A qualitative approach utilizing a causal descriptive survey method, also called mixed methods. With Lisrell, the research was analyzed using multiple linear regression and the Structural Equation Model (SEM) model.

Findings: The effectiveness of marketing communication in the development of beach tourism in Jayapura City is relatively low in the role of tourism managers and the use of media in tourism promotion. Coastal tourism managers are still dominated by the elderly who are not updated with digital technology. The potential of culture and local wisdom has not been optimized in tourism management. There has been no synergy between interested parties such as government, customary, and community in the application of tourism marketing communication.
Originality: Many studies have been conducted on tourism marketing communication strategies, but only a few have studied them from the perspective of tourism development which involves participation and local wisdom of the people in Papua. This study shows that marketing communication strategies are part of the solution, and research on local wisdom and community culture can provide alternative tourism development to improve the welfare of local communities.
The ED50 of Remazolam Toluenesulfonate Combined with a Subthreshold Dose of Esketamine for Inhibiting Cardiovascular Response to Tracheal Intubation in Elderly Patients
Authors: Zhao Chunyan , Tang Yi , Chen Cibo , Xia Bingchun
Published: May 2024

Objective: To explore the half-effective dose (ED50) of remazolam toluenesulfonate combined with subthreshold amounts of esketamine for inhibiting cardiovascular response to tracheal intubation in elderly patients. Method: We included 42 patients, aged 65–75, who required general anesthesia and single-lumen endotracheal intubation for elective surgery. The first patient was administered remazolam toluenesulfonate at a dose of 0.20 mg/kg. Once the patient lost consciousness, their alertness/sedation score (OAA/S score) was ≤ 1, and their BIS score was ≤ 60, and a subthreshold dose (0.3 mg/kg) of esketamine was given. The subsequent doses were adjusted using a sequential approach based on the cardiovascular response to tracheal intubation observed in the previous patient. The dose was modified in increments or decrements of 0.01 mg/kg. The ED50 and 95% CI of remazolam toluenesulfonate were calculated using the Dixon and Massey sequential distribution test method. Result: The inhibition of endotracheal intubation response was positively correlated with the dose of remazolam toluenesulfonate, and the depth of sedation could not be achieved when the amount was ≤ 0.22 mg/kg. The ED50 of remazolam toluenesulfonate combined with a subthreshold dose of esketamine in inhibiting cardiovascular response to tracheal intubation in elderly patients was 0.30 (0.28, 0.33) mg/kg. There was no statistically significant difference in blood pressure between the induction of anesthesia and before the operation. Conclusion: When compounded with 0.3 mg/kg esketamine, the ED50 of Remazolam toluenesulfonate in inhibiting cardiovascular response to endotracheal intubation in elderly patients was 0.30 mg/kg (95 % CI0.28–0.33 mg/kg).
Analysis of the Efficacy of Atomoxetine Hydrochloride Combined with Psycho-Behavioral Modification Therapy in the Treatment of ADHD in Children
Authors: Li Nan
Published: May 2024

Objective: To evaluate the therapeutic efficacy of atomoxetine hydrochloride (ATX) combined with psychological-behavioral modification therapy for attention-deficit/hyperactivity disorder (ADHD) in children. Methods: A total of 60 cases of ADHD children admitted to our hospital between November 2021 and November 2022 were selected and randomly grouped into Group I and Group II. There were 30 cases in Group I who were treated with ATX combined with psychological-behavioral modification therapy. There were 30 cases in Group II who were treated with ATX monotherapy, and the therapeutic effects were compared. Results: Before treatment, there was no difference in the behavioral problem scores and cognitive function indexes of the two groups (P＞0.05). After treatment, the behavioral problem scores of Group I were lower than those of Group II, and the cognitive function indicators of Group I were lower than those of Group II (P < 0.05). The adverse reaction rate of Group I was lower than that of Group II, and the total effective rate was higher than that of Group II (P < 0.05). Conclusion: ATX combined with psychological-behavioral modification therapy improved the behavioral problems of ADHD children, enhanced their cognitive function, and reduced the adverse reactions to drug treatment.
Pull-out response of a geogrid buried in recycled sands
Authors: Oliveira Priscila , Santos Eder , Palmeira Ennio
Published: May 2024

Recycled construction and demolition waste (RCDW) has demonstrated geotechnical properties that encourage it to be used in reinforced soil structures (RSS) with geosynthetics. However, the interaction between RCDW and reinforcements needs to be better understood, given its importance for design. This paper presents a qualitative study on the interaction between geogrid and recycled sands by means of pull-out tests performed on small equipment. Tests with the same degree of compaction and a geogrid buried in different types of recycled and natural sands (for comparison purposes) were performed. The characterisation of the materials was carried out in the laboratory and the variability of their geotechnical properties was evaluated. In addition, fill material moisture content was investigated as another potential factor influencing soil-geogrid interface shear. The results of the pull-out tests demonstrated the specific influences of the factors investigated. The comparative study showed that recycled sands can be suitable materials to be used as backfill in geosynthetic reinforced soil structures, meeting physical, mechanical and environmental requirements for this kind of work.
hibridez comunicativa en imaginarios latinoamericanos en la cultura digital
Authors: Pacheco Díaz Angélica
Published: May 2024

Este artículo aborda la hibridez de la comunicación para crear de manera interdisciplinaria narrativas de los imaginarios comunes y públicos de mujeres latinoamericanas, mediante una trama intercultural desde su espacio biográfico.
A partir de una investigación iberoamericana[1] que culminó en una publicación de experiencia transmedia y que se encuentra en etapa de divulgación en diversos espacios locales, nacionales e internacionales, se presenta en este artículo un análisis de esta narración intercultural y su hibridación cultural en imaginarios comunes.
           Se aplicará una metodología basada en los análisis cualitativos de los contenidos de la comunicación intercultural del proyecto basado en un modelo circular narrativo de la trama diseñada para la construcción de narrativas con mujeres de América Latina.
 
[1] La investigación se denominó Imaginarios de las identidades híbridas latinoamericanas, desde las narrativas de la vida cotidiana de mujeres en la desigualdad de género en el marco del covid-19. Fue posible a través de la adjudicación de Fondos Internos de Investigación de la Universidad Viña del Mar, Chile, el año 2020.
Implementation of the Halal Assurance System and MSME Business Development Strategy: the Case of a Coffee Shop
Authors: Muslich Muhammad Ayyub , Nurhalim Asep , Irfany Mohammad Iqbal
Published: May 2024

This study aims to help a micro-small-medium enterprise (MSME), in this case Dakara Coffee, meet the requirements of HAS 23000. The identification carried out in this study was in the form of primary and secondary identification to apply the HAS Manual. The HAS Manual is designed based on the actual conditions of Dakara Coffee and contains 11 HAS criteria. The results showed that several identified food and beverage ingredients did not meet the HAS 23000 criteria and did not have supporting documents. Several improvements are then recommended such as replacing materials that do not comply with HAS 23000 and completing documents for food and beverage ingredients. Employing AHP method, the main priority for Dakara Coffee business development is location, followed by various other aspects such as halal management, branding strategy, product innovation, and organisational management.
SÍFILIS NA GESTAÇÃO: DESAFIOS DE SAÚDE PÚBLICA NO NORDESTE
Authors: STEFANI MARCIO ANTÔNIO , SOUSA MIRNA RIBEIRO FREITAS DE , FREITAS JULIANNE MIRLA DE ARAÚJO , TEIXEIRA MIRIAN VIEIRA , JORGE IGOR MARCEL CAFFARENA , SENA FERNANDO DA SILVA , GOMES ANDRÉIA PEREIRA DOS SANTOS , OLIVEIRA DANILLO LYRIO DE , SILVA GEIZA GRAZIELE , LOUREIRO DANIEL DE CAMARGO
Published: May 2024

Analisar a prevalência da sífilis na gestação no Nordeste brasileiro. Trata-se de um estudo
epidemiológico descritivo, com uma abordagem quantitativa. Os dados foram coletados
através da análise de uma base de dados do Departamento de Informática do Sistema
Único de Saúde (DATASUS), durante o período de 2018 a 2021, na região nordeste do
Brasil. Os dados revelam uma preocupante incidência de sífilis em gestantes na região
nordeste do Brasil entre 2018 e 2021, com um total de 47.014 casos confirmados.
Destaca-se que o estado mais afetado é Pernambuco, com 22,8% dos casos. Além disso,
observa-se uma prevalência significativa entre gestantes na faixa etária de 20 a 39 anos
(73,0%), de cor/raça parda (71,0%), e com níveis de escolaridade entre a 5a e a 8a série
do ensino fundamental incompleto (22,2%). A pesquisa destaca a necessidade de
enfrentar esse problema de saúde pública, incluindo estratégias de vigilância, acesso
facilitado a testes e tratamentos. Além disso, ressalta a importância de concentrar mais
esforços nas populações mais vulneráveis e implementar ações específicas para reduzir
as desigualdades sociais e o acesso irregular aos serviços de saúde.
CÂNCER DO COLO DO ÚTERO: EXAMES CITOPATOLÓGICOS REALIZADOS NO MUNICÍPIO DE TERESINA, PIAUÍ, DE 2020 A 2022
Authors: NASCIMENTO WANDERLENE DE OLIVEIRA DO , JUNQUEIRA MARINA DA SILVA , SILVA JUAN VICTOR DA , VASCONCELOS JOÃO HENRIQUE RAMOS DE , SOUSA MIRNA RIBEIRO FREITAS DE , GUEDES IZAIAS PEREIRA , FERREIRA MARIA TERESA DA SILVA , SOUSA ÁDILA CRISTINA SILVA DE , LOPES ALINE COSTA , CARVALHO CAMILA MENDES COSTA
Published: May 2024

Avaliar o rastreamento do câncer do colo do útero na cidade de Teresina – PI. Trata-se de
um estudo epidemiológico descritivo com abordagem quantitativa, cujos dados foram
obtidos por meio de consulta a uma base de dados do Sistema de Informação do Câncer
(SISCAN) na cidade de Teresina, Piauí, no período de 2020 a 2022. Foram registradas
87.476 citologias na faixa etária mais prevalente de mulheres com = 50 anos,
correspondendo a 29,57%. A maioria dos exames foi realizada com a finalidade de
rastreamento, totalizando 99,82%. Apresentaram alterações citológicas não normais
96,84% dos casos. Prevalecem os intervalos de um ano da realização do exame
citopatológico, representando 33,54% das frequências. Dentre as lesões das células
escamosas atípicas, o resultado mais prevalente foi LSIL, representando cerca de 0,64%.
Conclui-se que o rastreamento na cidade de Teresina está de acordo com as
recomendações do Ministério da Saúde. Entretanto, os resultados revelaram a necessidade
de manter a conscientização e o acompanhamento regular, evoluindo para a redução do
impacto do câncer do colo do útero.
PERSPECTIVA MULTIPROFISSIONAL PARA OS CUIDADOS PALIATIVOS ONCOLÓGICOS NO SISTEMA ÚNICO DE SAÚDE.
Authors: CHAGAS ANA CLARA LUZ , MESQUITA MARIA FERNANDA ALVES , SANTOS MARLI EDUARDA DE JESUS DOS , ALBERNAS RAQUEL SILVA , SILVA RAYANNE MEDEIROS DA , MARTINS CLAUDIA MARIA DA ROCHA
Published: May 2024

Evidenciar como a abordagem multiprofissional em cuidados paliativos oncológicos no
Sistema Único de Saúde (SUS) promove assistência integral, visando melhorar a
qualidade de vida de pacientes e familiares. A revisão de literatura abrangeu artigos de
2002 a 2023, utilizando descritores como cuidados paliativos, equipe de assistência ao
paciente, oncologia e sistema único de saúde. Destaca-se a necessidade urgente de
políticas públicas para embasar a prática multiprofissional em cuidados paliativos
oncológicos no SUS. A equipe multiprofissional, composta por profissionais de diversas
áreas da saúde, desempenha papel fundamental, mas enfrenta desafios, como a limitada
exposição nos cursos de saúde e pouco treinamento especializado, a ineficiência da
comunicação interdisciplinar e diretrizes pouco claras no SUS e alta de estratégias
governamentais, o que compromete a efetividade desses cuidados. Essas limitações
indicam a urgência de pesquisas mais detalhadas e da constante melhoria das políticas
públicas para elevar a qualidade dos cuidados paliativos. A atuação integrada da equipe
multiprofissional no SUS é essencial, e acompanha a necessidade de mais pesquisas e de
políticas públicas que proporcionem melhoria das condições de trabalho para o
profissional. Futuras investigações devem focar na eficácia das políticas existentes e na
compreensão das percepções dos profissionais e pacientes para assegurar uma assistência
humanizada e integral no enfrentamento do câncer no contexto do SUS.
Palavras-chave: Cuidados paliativos; Equipe de assistência ao paciente; Oncologia;
Sistema único de saúde.
CONTRIBUIÇÃO DA TERAPIA OCUPACIONAL PARA O DESENVOLVIMENTO DA ESCRITA DE UM ADULTO COM PARALISIA CEREBRAL ATRAVÉS DA TECNOLOGIA ASSISTIVA
Authors: Silva Maria Sofia Santos da , Lima Raffaela Silva de , Rodrigues Luzimara Vieira , Costa Maria de Fátima Góes da
Published: May 2024

A encefalopatia crônica não progressiva, conhecida
popularmente como Paralisia Cerebral (PC), é caracterizada por distúrbios neuropatológicos que implicam em acometimentos clínicos de âmbito motor, estando ou não associados a déficit cognitivo (Lino et al., 2020). Entre os principais padrões patológicos estão a alteração de tônus, postura e a persistência de reflexos, que dificultam
principalmente no alcance de habilidades dos membros superiores, o uso das mãos e a destreza dos dedos, impactando sobre os resultados educacionais, as Atividades de Vida Diária e a autonomia de indivíduos com PC (Codgno; Braccialli; Braccialli, 2018).
CAPACITISMO E ATITUDES CAPACITISTAS: UMA ANÁLISE A PARTIR DE PESQUISA-AÇÃO REALIZADA COM USUÁRIOS ATENDIDOS NO CENTRO ESPECIALIZADO EM REABILITAÇÃO III DA UNIVERSIDADE DO ESTADO DO PARÁ
Authors: Silva Elane do Socorro Oliveira da , Moraes Márcia Goretti Guimarães de , Cota Karen Regina Ferreira
Published: May 2024

Capacitismo é uma denominação, para muitos nova, mas que
expressa a atitude de preconceito e discriminação vivenciada por muitas pessoas com deficiência ou seus acompanhantes- cuidadores. O fato é que a palavra Capacitismo é, para muitas pessoas no
Brasil, uma palavra ainda desconhecida. A expressão “Capacitismo” é desconhecida, mesmo entre as pessoas com deficiência, familiares e profissionais. Mesmo no centro de reabilitação, como é o CER III/UEAFTO da UEPA, quase que cem por cento das pessoas que participaram da pesquisa, não conhece o que é Capacitismo ou atitudes consideradas capacitistas.
II Seminário Jornal na e da escola: práticas de alunos e professores - Caderno de resumos
Authors: Pereira Angélica de Oliveira Castilho
Published: May 2024

O II Seminário JORNAL NA E DA ESCOLA: práticas de alunos e professores é um desdobramento de nossas práticas no Projeto de Extensão Jornal na Escola no CAp-UERJ; na pesquisa de Iniciação Científica Júnior e Iniciação Científica Os Gêneros Jornalísticos em Práticas Pedagógicas; e no Estágio Interno Complementar Os Gêneros Jornalísticos em Sala de Aula.
A Study on Potential Feed Sources to Boost Guppy Fish, Poecilia reticulata Productivity
Authors: CV Vedhavarshini , Swetha A , Harini Sri M , Kaviya K , Ann Suji H , Deivesigamani B
Published: May 2024

Aquaculture may simply be referred as “Underwater Agriculture.”India is a major maritime state and an important aquaculture- based country in the worldhaving major aquaculture activitiesin the production of Carp from Freshwater,Shrimp from Brackish water, etc. Feed requirements of fish vary in quantity and quality according to the feeding habits, physiological stages of the species and environmental variations viz., temperature; amount and type of natural food availability in the culture system.A nutritious and cheap feed is a pre requested for profitable aquaculture. Though, use of commercially available feed is in practice in many countries. The feed cost consumes more Than half of running expenditure. Therefore, the search of nutritionally well-balanced feed Prepared from very cheap locally available ingredients in progress in all the aqua farming countries. In the present study, an attempt has been made to well-balanced nutritious feed Particularly from the locally available cheaper ingredients. The objectives of the present study are: to assess the effect of feed on the growth of finfish and shellfish in the laboratory, to prepare the conventional feed with traditional ingredients and to check the effect of feed on the growth performance of ornamental fish - Guppy, Poecilia reticulata.