bluuebunny/crossref_metadata_2025 huggingface dataset:
The Combination of Benson Relaxation and Pelvic Tilting on the Scale of Low Back Pain in Pregnant Women
Authors: Rani Rinda Harwidiana , Harmayetty Harmayetty , Kusumaningrum Tiyas
Published: August 2020

Introduction: Lower back pain in pregnant women trimester II and III causes difficulty in standing or even moving from bed, and the lousy impact is difficulty in walking if it has spread to the lumbar or pelvic region. The study aimed to know the effects of the combination of Benson relaxation and pelvic tilting on back pain in pregnant women.Methods: The research was Quasi-experiment. The population is second-trimester pregnant women who experience lower back pain in the Public Health Center Mojo and Public Health Center Gading, Surabaya. Purposive sampling was used to gain 56 respondents. The independent variable of this study was the second trimester pregnant women with low back pain treated for two weeks. The dependent variable was the intensity of the pain level. Research data obtained by pre-test and post-test with VAS questioner. Analyzed using the Wilcoxon sign rank test and Mann- Whitney test.Results: As a result of the combination of Benson's relaxation and pelvic tilting, there was an influence on the back pain of second-trimester pregnant women. Based on the Mann-Whitney test, there were significant differences in the treatment group or the control group with p = 0.000.Conclusion: The combination of Benson relaxation and pelvic tilting decreases the scale of low back pain in pregnant women. Pelvic tilting is more influential because it can reduce the pain scale.
Factors Associated with The Resilience of Breast Cancer Patients Undergoing Chemotherapy
Authors: Nira Ariyani Wisudawati , Triharini Mira , Nastiti Aria Aulia
Published: August 2020

Introduction: The management of chemotherapy in breast cancer requires a long time and cause miscellaneous of side effects. High resilience is needed by breast cancer patients to undergo chemotherapy regularly. This study aimed to analyze factors associated with the resilience of breast cancer patients undergoing chemotherapy.Methods: This study design was cross-sectional. From the total population of 122 breast cancer patients, a sample of 100 participants was selected using a purposive sampling technique. The independent variables were hardiness, education level, economic status, side effects of chemotherapy, family support, and anxiety. The dependent variable was resilience. The instruments of this study were Hardiness questionnaire, Chemothraphy-Symptom Assessment Scale (C-SAS), Family Support questionnaire, Zung-Self Rating Anxiety Scale (ZSRAS), and Connor-Davidson Resilience Scale (CD-RISC). The Spearmen’s Rho was used for statistical analysis.Results: Hardiness (p=0.000; r=0.310), Education Level (p=0.000; r=0.416), Economic Status (p=0.000; r=0.369), Side Effects of Chemotherapy (p=0.004; r=-0.283) and Family Support (p=0.000; r=0.579) have relation with the resilience. Anxiety has no relation with the resilience (p=0.23; r=0.121).Conclusion: The side effects management of chemotherapy and family support were necessary to increase the resilience of breast cancer patients undergoing chemotherapy. It is highly recommended to the next researchers to do some studies about factors associated with the side effects of chemotherapy and nursing intervention, which can reduce the side effects of chemotherapy itself.
The Correlation between Mothers' Breastfeeding Pattern and Stunting among Toddlers
Authors: Firdausya Tiffatul Jannah , Hardini Deisy Sri
Published: August 2020

Introduction: Stunting is a condition of the measured height of toddlers, which is less to the age. Stunting, which occurs in these children, is also considered in chronic nutrition problems. The study aimed to discover the correlation between breastfeeding mothers' pattern in breastfeeding for toddlers aged 0 days to 6 months with the stunting incidence in toddlers in Gandatapa village, Sumbang sub-district, Banyumas district.Methods: This study implemented an observational analytic method that examined the correlation between breastfeeding mothers' patterns and stunting incidence. This research design was case control. This study conducted two sampling techniques; total sampling and simple random sampling, and each was used for sampling and control groups. The research sample collected 80 respondents. The study used a questionnaire of breastfeeding mothers and TB/U observation charts for ages 2 to 5 years, according to WHO 2005.Results: Based on the bivariate analysis, the pattern of breastfeeding mothers in Gandatapa Village, Sumbang District, Banyumas Regency was in a bad category with 22 stunting toddlers (55%). Pearson Chi-Square test on the Pattern of Breastfeeding Mothers towards Stunting Incidents in toddlers obtained p-value = 0.024 <0.05 with an OR value of 2.852 (95% CI 1.137 - 7.152).Conclusion: Toddlers under 24 to 35 months can increase the risk of stunting incidence when mothers have poor breastfeeding patterns.
The Comparison of Total Cholesterol Level in DMPA and Combination Injection Contraception Users
Authors: Elfrida Rara Yumna , Sari Gadis Meinar , Dwiningsih Sri Ratna , Lestari Pudji
Published: August 2020

Introduction: Hormonal injection contraception is the most widely used method of contraception in Indonesia. In long-term use, one of the side effects of injection contraception is changes in lipid metabolism in the body caused by the accumulation of hormones in the body. Two types of injectional contraception are widely used in Indonesia, namely combined injection and DMPA injection; different hormonal content has various side effects on the lipid profile. This study aimed to compare the total cholesterol level between acceptors of DMPA injection and combined injection.Methods: This study used an observational analytic method with a cross-sectional approach. The sample size is 60 respondents, including 30 DMPA injection acceptors and 30 combination injection acceptors. The sampling method uses a purposive sampling technique The independent variable in this study was the total cholesterol level of the acceptor, and the dependent variable was the acceptor of DMPA injection and the combination injection acceptor. Analysis of research data used the Independent T-test with α=0.05.Results: The results of the bivariate analysis found significant differences in total cholesterol levels in the DMPA injection contraception acceptor and combination injection with p= 0.037. It was found that overall cholesterol levels of DMPA injection acceptors were higher.Conclusion: There is a difference in total cholesterol levels in the DMPA injection contraception acceptor with a combination injection contraception acceptor.
The Correlation Between Personal Reference: Health Workers and Health Facilities with Parenting in Stunting Prevention
Authors: Fajrianti Dita , Yunitasari Esti , Pradanie Retnayu
Published: August 2020

Introduction: The influence of parenting, the scope and quality of health services, the environment, and food are the leading causes of stunting. This study aims to analyze the correlation between personal reference and health facilities with parenting in stunting prevention in Madura East Java.Methods: The design of this study was a cross-sectional study. The population in this study were mothers who had children aged 6-24 months in Madura East Java with 149 mothers and obtained a sample of 109 mothers selected using a purposive sampling technique. The independent variable was the personal reference and health facilities. At the same time, the dependent variable was parenting in stunting prevention. The data were collected using a questionnaire. The questionnaire has been a validity and reliability test. This study was analyzed using the Spearman rho test with a significance level α <0.05.Results: Personal reference have a correlation in parenting in stunting prevention with significance (p=0.017; r=0.228) Health care facilities have a correlation in parenting in stunting prevention with significance (p=0.020; r=0.222)Conclusion: Personal reference and health facilities have a significant role in parenting in stunting prevention. Health workers are expected to be able to provide interventions that are compatible with stunting prevention factors to reduce the incidence of stunting in Indonesia. The more complete health facilities to provide information about pediatric health, the more capable the mother to provide prevention in stunting on children.
İstanbul’da bir aile hekimine kayıtlı erkeklerin gebelikten korunma durumu ve gereksinimlerinin araştırılması
Authors: KAYA Mehmet , ÖZGÜLNAR Nuray
Published: August 2020

Amaç: Geleneksel olarak üreme sağlığı programları ve araştırmaları çoğunlukla kadınlar üzerine yoğunlaşmaktadır. Oysa üreme süreci ve sağlığı için kadın ve erkek birlikte roller üstlenir, sorumluluk taşırlar. Bu araştırmada; erkeklerin, gebelikten korunma yöntemleri konusunda bilgi düzeyleri, tutum ve davranışları hakkında bilgi toplamak ve bu konudaki gereksinimlerini belirlemek amaçlanmıştır. Gereç ve Yöntem: Bu kesitsel araştırma İstanbul’da bir Aile Sağlığı Merkezindeki bir aile hekimine kayıtlı 18-65 yaş arasındaki erkek nüfustan basit rastgele örnekleme yöntemi ile seçilen 264 kişi ile yürütülmüştür. Belirlenen 264 kişilik örneklem büyüklüğü arasından, 171 bireye ulaşılmıştır. Örnekleme ulaşma oranı %64,7’dir. Veriler yüz yüze görüşme tekniği ile gebelikten korunma yöntemlerini irdeleyen anket formuyla toplanmıştır. Verilerin analizinde, sürekli değişkenler için Mann-Whitney U testi, kategorik değişkenler için Ki-Kare ve Fisher Exact testi kullanılmıştır. Çok değişkenli analizler için Lojistik Regresyon Analizi yapılmıştır. Bulgular: Erkeklerin halen en sık kullandığı yöntem %35.7 ile kondomdur ve onu %19.3 ile geri çekme yöntemi takip etmektedir. Vazektomi uygulaması yapılmış erkek yoktur. Kondom kullanımını etkileyen faktörleri saptamak için yapılan çok değişkenli analizler sonucunda kondom kullanımının yaş ve eğitimle ilişkili olduğu belirlenmiştir. Erkeklerin üreme sağlığı konularında en sık başvurdukları bilgi kaynakları %75.4 ile internet ve %56.1 ile sağlık personelidir. Sonuç: Üreme sağlığı hizmetlerinin genişletilerek verimliliğinin artırılması için bu hizmetlerin hedef kitlesi kapsamına erkeklerin de dahil edilmesi gerekmektedir.
Assessment of the relationships between optimistic life orientation and hope levels and health-related quality of life in parents
Authors: ÖCAL Ece Elif , AYGAR Hatice , ATAY Emrah , ÖZTÜRK EMİRAL Gülsüm , ÖNSÜZ Muhammed Fatih , METİNTAŞ Selma
Published: August 2020

Objective: Approaching life with optimism and hope will increase one’s psychological well-being and quality of life. The aim of this paper was to evaluate the association between optimism and hope levels in adults on health-related quality of life in physical and mental areas. Methods: This cross-sectional study was conducted at three different primary schools in Eskisehir with a sample of 674 parents of students. In order to collect data, a questionnaire consisting of 4 parts was formed after conducting a comprehensive literature review. The first part includes the sociodemographic characteristics of the parents, the second part of the health-related quality of life scale “Short Form 12 (SF-12)’’, the third part of the Life Orientation Test (LOT) and the fourth part ‘’Dispositional Hope Scale’’ questions. Mann-Whitney U, Kruskal-Wallis and multiple linear regression analyzes were used to evaluate the data. Results: The ages of participants ranged from 24 to 55 years, with a mean ± SD of 36.23 ± 4.49 years.The scores from the health-related quality of life Physical Component Summary (PCS) Score ranged from 25.0 to 63.2 with a median of 50.5, while the scores from the Mental Component Summary (MCS) Score ranged from 15.6 to 66.3 with a median of 49.5. When both scales were taken together into a regression model, the influence of the LOT on physical health disappeared, and the effect of the Dispositional Hope Scale continued. Conclusion: Optimism and hope are closely related to one’s state of health. In generally healthy groups, optimism and hope will reflect the tendency to stay
away from negative emotions and cognitions in order to protect one’s health. It was concluded that in order to improve one’s quality of life and health, it is important to make optimism and hopefulness a part of life.
Sağlık araştırmalarında güç analizinin önemi ve temel prensipleri: Tıbbi çalışmalar üzerinde uygulamalı örnekler
Authors: KALAYCIOĞLU Oya , AKHANLI Serhat Emre
Published: August 2020

Amaç: Güç analizi ile örneklem büyüklüğü tahmini tıbbi araştırmacılar ve etik kurulu üyeleri tarafından çoğu zaman yanlış yorumlanan bir konudur. Bu çalışmada, istatistik alanı dışından olan araştırmacıların, örneklem büyüklüğü, etki büyüklüğü ve istatistiksel güç ile ilgili sorularının cevaplanması amaçlanmıştır. Yöntem: Bu kapsamda, farklı tıbbi araştırma düzenlerinde güç analizi gerçekleştirmek için kullanılacak etki büyüklüklerinin ne anlama geldiği ve nasıl hesaplandığı anlatılmıştır. Farklı etki büyüklüklerinde, farklı istatistiksel güç düzeylerinde ve %5 istatistiksel anlamlılık seviyesinde bağımsız gruplar için t-testi, tek yönlü ANOVA ve Ki-kare testleri için gerekli olan örneklem büyüklükleri GPower 3.1 programı kullanılarak hesaplanmıştır. Bulgular: Farklı istatistiksel testler için gerçekleştirilen güç analizleri, etki büyüklüğünün örneklem sayısı belirlemede ne derecede önemli rol oynadığını göstermiştir. Gereğinden az sayıda birim üzerinde deney yapılması gerçekte var olan önemli bir etkinin tespit edilememesine neden olabilirken, çok fazla sayıda örnek üzerinde test yapılması istatistiksel olarak anlamlı fakat gerçekte klinik olarak önemsiz bir etkinin tespit edilmesine yol açabilir. Sonuç: Sonuç olarak, bir araştırma kapsamında beklenen klinik anlamlılığı ortaya çıkarmak için alınması gereken etki büyüklüğü, araştırma hipotezi ile uyumlu belirlenmelidir. Çünkü araştırma sonucunda verilecek kararların niteliği ve klinik anlamlılığı örneklemin hangi etki büyüklüğüne dayanarak seçildiğine bağlıdır.
Statins, Bone Biology and Revision Arthroplasty: Review of Clinical and Experimental Evidence
Authors: Sorial Antony K. , Anjum Sami A. , Cook Michael J. , Board Tim N. , O'Neill Terence W.
Published: August 2020

Osteoarthritis is a painful, disabling condition which is increasing in prevalence as a result of an ageing population. With no recognised disease limiting therapeutics, arthroplasty of the hip and knee is the most common and effective treatment for lower limb osteoarthritis, however lower limb arthroplasty has a finite life-span and a proportion of patients will require revision arthroplasty. With increasing life expectancy and an increasing proportion of younger (<65 years) patients undergoing arthroplasty, the demand for revision arthroplasty after implant failure is also set to increase. Statins are cholesterol modulating drugs widely used for cardiovascular risk reduction which have been noted to have pleiotropic effects including potentially influencing arthroplasty survival. In vitro studies have demonstrated pleiotropic effects in human bone cells, including enhancement of osteoblastogenesis following simvastatin exposure, and in vivo studies have demonstrated that intraperitoneal simvastatin can increase peri-implant bone growth in rats following titanium tibial implant insertion. There is evidence also that statins may also influence osseointegration, enhancing bone growth at the bone-implant interface, subsequently improving the functional survival of implants. Data from the Danish Hip Arthroplasty Registry and Clinical Practice Research Datalink in the UK suggest a reduction in the risk of lower limb revision arthroplasty in statin ever-users vs never users, and a time dependent effect of statin administration on reduction in risk of revision. In this article we review the clinical and scientific evidence linking statins and risk of revision arthroplasty.
How to Construct a Bottom-up Nomothetic Network Model and Disclose Novel Nosological Classes by Integrating Risk Resilience and Adverse Outcome Pathways with the Phenome of Schizophrenia
Authors: Maes Michael , Vodjani Aristo , Galecki Piotr , Kanchanatawan Buranee
Published: August 2020

Current case definitions of schizophrenia (DSM-5, ICD), made through a consensus among experts, are not cross-validated and lack construct reliability validity. The aim of this paper is to explain how to use bottom-up pattern recognition approaches to construct a reliable and replicable nomothetic network reflecting the direct effects of risk resilience (RR) factors, and direct and mediated effects of both RR and adverse outcome pathways (AOPs) on the schizophrenia phenome. This study was conducted using data of 40 healthy controls and 80 patients with schizophrenia. Using partial least Squares (PLS) analysis, we found that 39.7% of the variance in the phenomenome (lowered self-reported quality of life) was explained by the unified effects of AOPs (IgA to tryptophan catabolites, LPS, and the paracellular pathway, cytokines, and oxidative stress biomarkers), the cognitome (memory and executive deficits), and symptomatome (negative symptoms, psychosis, hostility, excitation, mannerism, psychomotor retardation, formal thought disorders); 55.8% of the variance in the symptomatome was explained by a single trait extracted from AOPs and the cognitome; and 22.0% of the variance in the latter was explained by the RR (Q192R polymorphism and CMPAaase activity, natural IgM, and IgM levels to zonulin). There were significant total effects (direct + mediated) of RR and AOPs on the symptomatome and phenomenome. In the current study, we built a reliable nomothetic network that reflects the associations between RR, AOPs, and the phenome of schizophrenia and discovered new diagnostic subclasses of schizophrenia based on unified RR, AOPs, and phenome scores.
Modeling and Prediction of COVID-19 Outbreak in India
Authors: Kumar Saurabh , Agiwal Varun , Kumar Ashok , Kumar Jitendra
Published: August 2020

As the outbreak of coronavirus disease 2019 (COVID-19) is continuously increasing in India, so epidemiological modeling of COVID-19 data is urgently required for administrative strategies. Time series and is capable to predict future observations by modeling the data based on past and present data. Here, we have modeled the epidemiological COVID-19 Indian data using various models. Based on the collected COVID-19 outbreak data, we try to find the propagation rule of this outbreak disease and predict the outbreak situations in India. For India data, the time series model gives the best results in the form of predication as compared to other models for all variables of COVID-19. For new cases, new deaths, total cases and total deaths, the best fitted ARIMA models are as follows: ARIMA(0,2,3), ARIMA(0,1,1), ARIMA(0,2,0) and ARIMA(0,2,1). Based on time series analysis, we predict all variables for next month and conclude that the predictive value of Indian COVID-19 data of total cases is more than 20 lakhs with more than 43 thousand total deaths. The present chapter recommended that a comparison between various predictive models provide the accurate and better forecast value of the COVID-19 outbreak for all study variables.
Spike Protein of SARS-CoV-2: Impact of Single Amino Acid Mutation and Effect of Drug Binding to the Variant-in Silico Analysis
Authors: Manickavasagam Pratibha
Published: August 2020

Novel SARS-CoV-2, a bat based virus originated in Wuhan, China that caused a global pandemic in December, 2019 belongs to the Betacorona virus family and contains single stranded genome of ~29Kbp. The host cell invasion of SARS-CoV-2 is facilitated by interaction of C-Terminal Domain (CTD) of Spike (S) protein of virus and host ACE2 receptor in the presence of TMPRSS seine protease secreted by the host cell. In this study the mutation hotspots of S-protein will be identified and the impact of such mutation in the binding affinity will be studied. Additionally, the lead molecule which can bind to the mutated protein also will be identified. Multiple sequence alignment of the spike protein sequence of SARS-CoV-2 shows the number of single amino acid mutation hotspots such as L5F, R214L, R408I, G476S, V483A, H519Q, A520S, T572I, D614G and H655Y. Among these mutations D614G has 57.5% occurrence and G476S, V483A has 7.5% occurrence. The mutated proteins were modelled based on wild type homolog and docked to ACE2 receptor. When the mutated S protein is docked, the ∆G (binding free energy) value is very minimal in mutated protein showed the stability of variants. By the drug repurposing method, 1000 FDA approved drugs were virtually screened for its binding to RBD of S1 domain. Among these drugs Digitoxin, Gliquidone and Zorubicin Hcl binds to spike proteins with higher docking score (lesser than -8.5 Kcal/mol) to both wild type and mutants.
An Integrated Approach to Air Passenger Index Prediction: Mutual Information Principle and Support Vector Regression (MI-Svr) Blended Model
Authors: Xiong Honglin , Fan Chongjun , ANTWI Collins Opoku , yang yun , fan Xiaomao
Published: August 2020

Air passenger traffic prediction is crucial for the effective operation of civil aviation airports. Despite some progress in this field, the prediction accuracy and methods need further improvement. This paper proposes an integrated approach to the prediction of air passenger index as follows. Firstly, the air passenger index is defined and classified by the K-means clustering method. Based on the mutual information (MI) principle, the information entropy is used to analyze and select the key influencing factors of air passenger travel. By incorporating the MI principle into the support vector regression (SVR) framework, this paper presents an innovative MI-SVR machine learning model used to predict the air passenger index. Finally, the proposed model is validated by passenger throughput data of the Shanghai Pudong International Airport, China. The experimental results prove the model feasibility and effectiveness by comparing them with conventional methods, such as ARIMA, LSTM, and other machine learning models, outperformed by the MI-SVR model. Besides, it is shown that the prediction effect of each model could be improved by introducing influencing factors based on mutual information. The main findings are considered instrumental to the airport operation and air traffic optimization.
Eating Disorders in Children and Adolescents. An Updated Review on Screening Methods
Authors: Leti Maria M. , Pop Anca L. , Garner David M. , Dobrescu Iuliana
Published: August 2020

This article aims to review the screening and diagnostic tools for eating disorders (ED). Eating disorders represent a complex pathology defined by an imbalance between hunger and satiety, installed in an emotional, traumatic, or conflictive context. Recently, the emphasis regarding ED is focused on the link between genetics, mental pathology, and the somatic and metabolic phenotype and early detection. Early detection and intervention can assure a better recovery and can improve a lot the quality of life of these patients. Methods: We selected ten articles of central importance on the topic in a systematic search on eight databases, articles selected on the type of scales, and size of the study. Results: We identified eight questionnaire scales used in large trials in ED disorders in the scanned literature, choose because we consider it the most accurate and the ones that evaluate best the pathology and the elements that are important as specific traits in ED. There are interview-type scales and self-administered scales. Interview scales are characterized by assessments of symptoms and diagnosis, while self-administered assess particular traits and the possibility of further development of eating disorders. The majority of the scales evaluated were described and used in adult populations. From all the scales assessed and analyzed, only three are described at the child population – it is EAT-26 (> 16 years), EDI-3 (>13 years), and ANSOCQ (> 13 years). Conclusions: It is essential to develop specific scales for people under 18 years of age, given the increasing incidence of ED among children and the need for early detection and appropriate intervention. Early detection of ED in children implies a simple and accurate evaluation at the primary care level or in schools, as the course of the disease can be subclinical for several years. Moreover, the need for accurate scales and telemedicine testing and diagnosis is of high importance during the COVID-19 pandemic as youth are at particular risk being psychologically affected due to disrupted education and social interactions - at a critical time.
Predatory Ants: First Report on Direct Evidence of Predation by Dorylus orientalis Westwood, 1885 on Olive Ridley Eggs from India
Authors: Korgaonkar Sumedha , Vartak Anuja , Sivakumar Kuppusamy
Published: August 2020

Abstract: Predation of eggs and emerging hatchlings of olive ridley turtle (Lepidochelys olivacea) by wild animals and feral dogs are known. They reduce the hatching success rate considerably affecting the conservation management of this vulnerable species. Hatchery management is practised in India to overcome predation. Ant predation is a serious threat to turtle nest protected by ex situ or in situ erected hatchery. This article reports the first direct evidence of turtle eggs predation by Dorylus orientalis Westwood, 1835 commonly called red ants. Native to India, Oriental, Indo Australian and Palearctic regions they are notorious as an agricultural pest. Chlorpyrifos pesticides recommended for their control could become fatal for the developing embryos of turtles if applied near the hatchery. In the turtle nesting site of the west coast of India, D. orientalis has more of an ecological role than as a pest. Natural pesticide such as Neem powder (Azadirachta indica) shows promising results for preventing their infestation.
Effects of Kifunensine on Production and N-glycosylation Modification of Butyrylcholinesterase in a Transgenic Rice Cell Culture Bioreactor
Authors: Macharoen Kantharakorn , Li Qiongyu , Márquez-Escobar Veronica A. , Corbin Jasmine M. , Lebrilla Carlito B. , Nandi Somen , McDonald Karen A.
Published: August 2020

The production and N-glycosylation of recombinant human butyrylcholinesterase (BChE), a model highly glycosylated therapeutic protein, in a transgenic rice cell suspension culture treated with kifunensine, a strong α-mannosidase I inhibitor, was studied in a 5 L bioreactor. A media exchange was performed at day 7 of cultivation by removing spent sugar rich media (NB+S) and adding fresh sugar free (NB-S) media to induce the rice α-amylase 3D (RAmy3D) promoter to produce rice recombinant human BChE (rrBChE). Using a 1.25X concentrated sugar-free medium together with an 80% reduced working volume during the media exchange lead to a total active rrBChE production level of 79 ± 2 µg (g FW)-1 or 7.5 ± 0.4 mg L-1 in the presence of kifunensine, which is 1.5-times higher than our previous bioreactor runs using normal sugar free medium with no kifunensine treatment. Importantly, the amount of secreted active rrBChE in culture medium was enhanced in the presence of kifunensine, comprising 44% of the total active rrBChE at day 5 post-induction. Coomassie stained SDS-PAGE gel and Western blot analyses reveal different electrophoretic migration of purified rrBChE bands with and without kifunensine treatment, which is attributed to different N-glycoforms. N-Glycosylation analysis shows substantial increase of oligomannose glycans (Man5/6/7/8) in rrBChE treated with kifunensine compared to controls. However, mass transfer limitation of kifunensine is likely the major reason for incomplete inhibition of α-mannosidase I in this bioreactor study.
Observations from the Data Integration and Imaging Informatics (DI-Cubed) Project
Authors: Clunie David , Hickman Hubert , Ver Hoef Wendy , Hastak Smita , Evans Julie , Neville Jon , Wagner Ulrike
Published: August 2020

In this paper we explore extending the concept of common cross-study Common Data Element concepts beyond simple demographics to cover disease-specific concepts relevant to imaging. We test interactively linking the resulting database to the associated images in a federated manner. We examine the use of existing standards, not only for terminology, but for interchange of serialized data in forms familiar to imaging and clinical trials specialists and their dedicated systems. Our intent is to perform preliminary work to inform both the upcoming Imaging Data Commons specifically, as well as more general integration projects beyond imaging.
The Association Between Presence of Comorbidities and COVID-19 Severity; A Systematic Review and Meta-Analysis
Authors: Honardoost Maryam , Janani Laila , Aghili Rokhsareh , Emami Zahra , Khamseh Mohammad E
Published: August 2020

Results: A total of 6270 individuals were assessed (1615 severe and 4655 non-severe patients). The median age was 63 (95% CI: 49-74) and 47 (95% CI: 19-63) years in the severe and non-severe groups, respectively. Moreover, about 41% of patients had comorbidities. Severity was higher in patients with history of cerebrovascular disease: OR 4.85 (95% CI: 3.11-7.57). The odds of being in severe group increase by 4.81(95% CI: 3.43-6.74) for history of cardiovascular disease (CVD). This was 4.19 (95% CI: 2.84-6.19) for chronic lung disease and 3.18, 95% CI: 2.09-4.82 for cancer .The odds ratio of a diabetes and hypertension were 2.61 (95% CI: 2.02-3.3), and 2.37( 95% CI: 1.80-3.13) respectively.
Allanites in the Sin Quyen IOCG deposit, North Vietnam
Authors: Nguyen Dinh Chau , Pieczonka Jadwiga , Piestrzynski Adam , Le Khanh Phon , Duong Van Hao
Published: August 2020

Abstract: Allanite minerals are the principal host of REEs in the Sin Quyen, Iron Oxide Copper Gold (IOCG) type deposit. The geochemical characteristics of these minerals are discussed in this work. The studied allanites have an unstable concentration of all major elements, such as REE (14-27 wt%), Ca (9-16 wt%), Al (8-19 wt%), Si (26-34 wt%) and Fe (12-21 wt%). Two different varieties of these minerals are documented, the older with higher REE concentrations ranging from 20 to 27 wt%, and younger with lower total REE concentration ranging from 14 to 19 wt%, which occur as a rim surrounding the older. Differences between the two groups of allanites are documented by Raman spectra and optical properties. The WDS chemical composition indicate that the allanites belong to the Ce-La-ferriallanite family, with low ƩHREE with an average of 0.21 wt.%. This work also supports the estimated timing of the deposit development focusing on detailed petrological study, and documented chemical composition of allanites confirmed by simplified statistical analysis.

Temperature 355ºC which was calculated using value of δ34S isotopes is interpreted as a temperature of the second crystallization stage of allanite group. The pressure of crystallization solution was calculated and is ranging from 0.98 to 5.88 MPa.
QUARTERLY FORECASTS OF NON-CASH TURNOVER IN POLAND FOR THE YEARS 2020 - 2022
Authors: Wiśniewski Jerzy Witold
Published: August 2020

The dynamic increase in non-cash transactions is a global trend in payments. In rich countries, cashless transactions have been dynamically replacing cash. The fact that non-cash transactions are pro-ecological is worth noting. This means that it is conducive to sustainable development of a country's economy. The purpose of this study is to analyze the process of changes in non-cash payments in Poland, against the background of payment card use for ATM cash withdrawals. The tool used to analyze the potential process of cash transaction erosion caused by non-cash payments is a two-equation econometric model with feedback. For this purpose, statistical data, obtained from the National Bank of Poland was used. Accordingly, clarification is expected regarding the question of whether the Polish payment system is heading towards a dominance of cashless transactions or not. The reaction, in the form of changes in the value of non-cash payment card transactions in Poland, affected by the increase in the wealth of citizens, measured by an increase in the average pay, was examined. The modeling results were used to estimate forecasts of the share of non-cash transactions in the total value of market transactions and of the share of ATM cash withdrawals in the total value of transactions.
A Systematic Review on Coronavirus Disease 2019 (COVID-19)
Authors: Karim Hira , Khan Muhammad Shahzeb
Published: August 2020

Emerging and reemerging pathogens is a global challenge for public health. Recently, a novel coronavirus disease emerged in Wuhan, Hubei province of China, in December 2019. It is named COVID-19 by World Health Organization (WHO). It is known to be caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) that affects the lower respiratory tract and manifests as pneumonia in humans. Coronaviruses (CoVs) are structurally more complicated as compared to other RNA viruses. This viral epidemic has led to the deaths of many, including the elderly or those with chronic disease or compromised immunity. Viruses cause infection and diseases in humans of varying degrees, upper respiratory tract infections (URTIs) cause common cold while lower respiratory tract infections induce pneumonia, bronchitis, and even severe acute respiratory syndrome (SARS). The costs of COVID-19 are not limited. It equally affects all the medical, sociological, psychological, and economic aspects globally. This is regarded as the third deadly outbreak in the last two decades after Severe Acute Respiratory Syndrome SARS (2002–2003) and Middle East Respiratory Syndrome MERS (2012). Based on the sequence homology of SARS-CoV-2, different animal sources including bats, snakes, and pangolins have been reported as potential carriers of this viral strain. Real-time RT-PCR represents the primary method for the diagnosis of new emerging viral strain SARS-CoV-2. The transmission dynamics suggest that SARS-CoV-2 is transmitted from person-to-person through direct contact or coughing, sneezing, and by respiratory droplets. Several anti-viral treatments including lopinavir/ritonavir, remdesivir, chloroquine phosphate, and abidor are also suggested with different recommendations and prescriptions. Protective and preventive strategies as suggested by various health organization i.e. WHO and US Center for Disease Control and Prevention (CDC) must be adopted by everyone. This review covers the important aspects of novel COVID-19 including characteristics, virology, symptoms, diagnostics, clinical aspects, transmission dynamics, and protective measures of COVID-19.
Strategi Komunitas Petani Jambu Madu Deli Dalam Pemberdayaan Masyarakat di Desa Kuryokalangan Kecamatan Gabus Kabupaten Pati
Authors: Wahida Emilia Nurul
Published: August 2020

Abstrak

Tulisan ini akan membicarakan tentang strategi komunitas kelompok petani jambu madu deli di desa Kuryokalangan mengenai pemberdayaan masyarakat terutama di bidang perekonomian.  Melihat adanya pengangguran di wilayah ini, komunitas petani jambu madu deli berinisiatif untuk memberdayakan masyarakat. Kesadaran untuk melakukan pemberdayaan di respon cukup baik oleh warga setempat,  namun terkadang ada pula yang meremehkan. Komunitas jambu ini sudah mulai berkembang dan mengalami penaikan sedikit demi sedikit.  Pemberdayaan ini bertujuan untuk meningkatkan perekonomian masyarakat khususnya para pemuda yang belum memiliki pekerjaan, ibu rumah tangga. Tak hanya sampai disitu, dengan adanya pemberdayaan ini diharapkan dapat meningkatkan pengetahuan dan keahlian petani dalam meningkatkan hasil dari tanaman jambu tersebut.

Penelitian ini bersifat kualitatif deskriptif, data penelitian diperoleh menggunakan wawancara, dokumentasi. Perlu adanya kerjasama antara komunitas petani jambu madu deli dengan pemerintah desa setempat.

Hasil penelitian dari karya tulis ini menjelaskan bahwa strategi pemberdayaan masyarakat yang dilakukan oleh komunitas ini adalah pemberdayaan berdasarkan teori PAR (Participatory Action Research), dengan teori ini diharapkan dapat berjalan dengan seoptimal mungkin.

Kata kunci : pemberdayaan masyarakat, komunitas petani jambu madu deli, ekonomi.

Abstract

This article wil discuss the comunity strategy of the Deli Guava Honey farmers group in the Kuryokalangan village, Gabus sub district  Pati Regency. Regarding community empowerment especially in the economic field. Seeing unemployment in this area, the Deli guava honey community initiative to empower the community awareness to empower people is quite good in response to loval resident. But sometimes there is also an underestimation the guava honey community began ti develop and experience a gradual increase. This empowerment aims to improve the community eceonomy, especially young people who do not have jobs, housewives not only that with this empowerment increase the insight, ability, and expertise of farmers in increasing crop yields.

This research is descriptive qualitative, research dats obtained using interviews, documentation. There is a need for cooperation between the community of Deli guava hiney farmers and the local village government

Research results from this paper, explain that the strategy of community is empowerment based on Particpatory Action Research theory and is expected to run as optimal as possible.

Keyword : community development, deli honey guava farmers community, the economy.
Peran Masjid dalam Pemberdayaan Ekonomi dan Sosial Umat di Tengah Pandemi Covid-19, Studi Kasus: Masjid Al-Mizan Griya Tahunan Indah Jepara.
Authors: Ilmi Firda Wasi’atul , Amin Alhakim Muhammad Ilham
Published: August 2020

Abstract

This study aims to analyze the role of mosques in economic and social empowerment during social distancing or movement restrictions due to the spread of the Coronavirus Disease pandemic (Covid-19). Covid-19 has become a problem for people in all fields, especially in the health, social and economic fields. The role of the mosque in empowering the social economy can provide assistance to the surrounding community. The method used in this study uses the literature study method. Efforts to empower the social economy of the people in the midst of a pandemic include: providing assistance to the surrounding community in the form of food supplies. The results of this study indicate that the role of the mosque is needed in economic and social empowerment of the people in the midst of the Covid-19 pandemic. From the results of these studies, economic empowerment activities can be carried out by providing food packages to the people who are affected by the corona virus (Covid-19).
Keywords: The Role of the Mosque, Empowerment of the Social Economy, Pandemic Covid-19
 

 Abstrak

Penelitian ini bertujuan untuk menganalisis peran masjid dalam pemberdayaan ekonomi dan sosial pada masa social distancing atau pembatasan gerak akibat adanya penyebaran pandemi Coronavirus Disease (Covid-19). Covid-19 ini menjadi problem masyarakat di segala bidang terutama dalam bidang kesehatan, soial, maupun ekonomi. Peran masjid dalam pemberdayaan ekonomi sosial dapat memberi bantuan bagi masyarakat sekitar. Metode yang digunakan dalam penelitian ini menggunakan metode studi kepustakaan. Upaya pemberdayaan ekonomi sosial umat di tengah pandemi meliputi: pemberian bantuan kepada masyarakat sekitar berupa sembako. Hasil dari penelitian ini menunjukkan bahwa peran masjid sangat dibutuhkan dalam pemberdayaan ekonomi dan juga sosial umat ditengah pandemi Covid-19. Dari hasil penelitian tersebut maka kegiatan pemberdayaan ekonomi dapat dilakukan dengan memberikan bantuan paket sembako kepada masayarakat yang sedang terdampak virus corona (Covid-19).

Kata Kunci: Peran Masjid, Pemberdayaan Ekonomi Sosial, Pandemi Covid-19
Kolaborasi Pemerintahan Desa dan Masyarakat Dalam Penanggulangan Pada Dampak Pandemi Covid 19 di Desa Karang
Authors: Yulianti Riska , Khalimatussa’diyah Nur
Published: August 2020

ABSTRAK

Tujuan dalam penulisan ini adalah menjelaskan bahwa kolaborasi masyarakat pada penanggulangan dan pecegahan pada pandemic corona virus disease 19 ( covid 19) di Desa Karang itu sangat penting. Dalam penanggulangan dan pencegahan dampak pandemi covid 19 ini pemerintahan desa dan tokoh- tokoh desa ikut unggul dalam kegiatan aksi tersebut. Pada kolaborasi penanggulangan ini menggunakan metode kualitatif dan metode PAR yang di lakukan dengan cara membentuk progam aksi  pratisipasi masyarakat yang bertujuan untuk mengubah kondisi sosial dari pandemic covid tersebut. Kolaborasi yang di lakukan masyarakat tersebut merupakan salah satu kunci utama dalam menjalankan keberhasilan dalam pencegahan dan juga penyebaran wabah Covid-19 ini. Sosial Distancing ataupun Physical distancing merupakan salah satu kegiatan utama yang harus diterapkan guna untuk memotong rantai dari penyebaran virus corona atau biasa disebut dengan Covid-19. Sebagian masyarakat pun sadar maka masyarakat akan mengikuti mekanisme dalam pembatasan sosial ini, tetapi  masih ada sebagian juga yang belum berpartisipasi dalam aksi penanggulangan penyebaran covid 19.Tulisan ini mengkasi Kolaborasi masyrakat dalam pencegahan penyebaran virus pandemic Covid-19 di Desa Karang. Penanganan penyebaran pandemic virus Covid-19 ini dapat terlaksanakan dengan baik jika masyarakat ikut serta mengikuti himbauan yang di buat oleh pemerintah untuk selalu melakukan kegiatan- kegiatannya salah satunya melakukan jaga jarak dan tetap tinggal di rumah (stay at home).

Kata Kunci : Kolaborasi Masyarakat, Penanggulangan Pandemi Covid 19, Pemerintahan Desa
Peningkatan Kesehatan Masyarakat Dampak Dari Pembakaran Genteng di Desa Ngembalrejo, Kecamatan Bae, Kabupaten Kudus
Authors: Wahyuni Sinta
Published: August 2020

Abstrak

Industri pembuatan genteng merupakan salah satu mata pencaharian masyarakat Desa Ngembalrejo, hampir sebagian besar masyarakat di desa ini bekerja sebagai pembuat genteng. Hingga menjadi ciri khas bagi desa Ngembarejo sendiri yang terkenal dengan desa pembuat genteng dengan kualitas yang bagus. Pembuatan genteng ini sebenarnya sudah ada di daerah ini cukup lama, dapat di katakan warisan para leluhur. Para pembuat genteng ini selalu mengutamakan kualitas dari genteng yang mereka buat, hal ini terbukti dengan mereka masih menggunakan pembakaran secara manual meskipun saat ini perkembangan teknologi sudah sangat canggih. Tak lepas dari itu, ada pula dampak negatif yang dapat mengganggu kesehatan masyarakat yang tinggal di sekitar tempat pembuatan genteng. Asap dari pembakaran genteng yang sampai saat ini belum dapat diatasi, asap tebal hitam dan pekat menjadi pemandangan setiap hari bagi masyarakat desa Ngembalrejo. Keadaan ini menjadikan menurunnya kualitas udara di Desa Ngembalrejo, namun situasi ini belum juga dapat membuat masyarakat sadar akan pencemaran udara yang terjadi. Mereka tetap menjalankan kehidupan mereka dengan baik-baik saja, padahal tanpa sadar mereka menghirup udara yang tidak sehat setiap harinya.

Abstrak
            Tile making industry is one of the jobs of the people in Ngembalrejo Village, most of the Ngembarejo Village community work as tile makers. To become a characterisic for the village of Ngembalrejo it self which is famous for its tile making village with good quality. This tile making has actually been around in this area for quite a long time, it can be said as the legacy of the ancestors. These tile makers always prioritize the quality of the tile’s they mae, this is proven by their still using manual combustion even though the current technological development has been vety sophisticated. It cannot be separated from that there are also egative impact that can interfere with the health of the people who live around the roof tile. Smoke from the burning of tiles which until now has not been able to be overcome, thick black and thick smoke becomes a daily sight for the people of the Ngembalrejo Vilage. This situation makes the air quality decline in the village og Ngembalrejo, but this situation has not been able to make the community aware of the air pollution that occurs. They still run their lives well, even though they unconsciously breathe un healthy air every day.
Quantitative Response of Healthy Muscle Following the Induction of Capsaicin: An Exploratory Randomized Controlled Trial
Authors: Evans Valerie , Behr Michael , Masani Kei , Kumbhare Dinesh
Published: August 2020

Background: Myofascial pain syndrome (MPS) is a prevalent chronic pain disorder primarily characterized by myofascial trigger points (MTrP). There is limited knowledge on the pathophysiology and mechanisms underlying MTrP and its development. Research has previously demonstrated the identification of MTrPs using ultrasound and vibrationsonoelastography, although there is some contradictory evidence regarding if MTrPs present as hyper or hypoechoic regions. Electromyography (EMG) investigations of MTrP have demonstrated that MTrP are usually located proximal to innervation zones where the peak surface EMG signals are obtained from. Central sensitization has been proposed as the primary mechanism underlying MTrP development. Central sensitization is associated withhyperexcitability of neuronal responses to normal or noxious stimuli. There is a need for a study that measures ultrasound image textural changes and motor unit activity responses in the muscle following sensitization. The purpose of this study is to determine whether sensitizing healthy muscle using capsaicin induces a regional change in image texture variables within the specific and surrounding muscles, as well as the motor unit frequency and amplitude changes that accompany them. This is an exploratory trial that aims to provide preliminary evidence on whether central sensitization is a direct cause of taut band and MTrP development.Methods: Ethical approval was obtained from the University Health Network (UHN)Research Ethics Board. This proposed study is a single centered, factorial, randomized placebo-controlled trial with two independent variables, depth of capsaicin application and dose of capsaicin, for a total of six treatment arms and three control treatment groups. Discussion: This will be the first study that assesses the B-mode ultrasound image texture of induced sensitized muscles, and will provide more evidence on muscle motor unit activity and regional changes of central sensitization. Findings from this study may support one of few hypotheses proposed delineating the involvement of central sensitization in the development of trigger points.Trial Registration: Name: National Institutes of Health ClinicalTrials.gov.Identifier: NCT03944889Date of Registration: May 07 2019URL: https://clinicaltrials.gov/ct2/show/NCT03944889
Implantation of Impella CP left ventricular assist device under the guidance of three-dimensional intracardiac echocardiography.
Authors: Yastrebov Konstantin , Brunel Laurencie , Williams Zoe , Wise Innes , Burrows Christopher , Paterson Hugh , Bannon Paul
Published: August 2020

Impella CP is a percutaneously inserted left ventricular assist device indicated for temporary mechanical cardiac support during high risk percutaneous coronary interventions and for cardiogenic shock. The potential application of Impella has become particularly relevant during the current COVID-19 pandemic, for patients with acute severe heart failure complicating viral illness. Standard implantation of the Impella CP is performed under fluoroscopic guidance. Positioning of the Impella CP can be confirmed with transthoracic or transoesophageal echocardiography. We describe an alternative approach to guide intracardiac implantation of the Impella CP using two-dimensional and three-dimensional intracardiac echocardiography. This new technique can be useful in selected groups of patients when fluoroscopy, transthoracic and transoesophageal echocardiography is deemed inapplicable or limited for epidemiological or clinical reasons. Intracardiac three-dimensional echocardiography is a feasible alternative to the traditional techniques for implantation of an Impella CP device but careful consideration must be given to the potential limitations and complications of this technique.