bluuebunny/crossref_metadata_2025 huggingface dataset:
MeToo movement and sexual violence in women: A qualitative study from Zambia
Authors: Muzyamba Choolwe Mphanza
Published: April 2020

BackgroundDespite the dominance of the #MeToo movement in the fight against sexual violence around the world, the experiences of most vulnerable women in countries like Zambia have been generally ignored in literature. Little is known about how useful this movement is to these women. Thus the aim of this study is to fill this gap by investigating the usefulness of the #MeToo movement as a tool for handling sexual violence among women in Zambia.MethodsThe study makes use of Focus Group Discussion. It involves a sample size of 80 participants. All participants had indicated that they had suffered sexual violence at least once in their lifetime. In the recruitment process, we ensured diversity in terms of age, marital status, employment status, ethnicity, and religious affiliation. Data was analyzed using thematic analysis.ResultsThere is no doubt that the MeToo movement is a useful catalysts for highlighting the severity of sexual violence and creating opportunities of redress in Zambia. However, currently its adoption and implementation seems to be blind to the ways privilege and subordination interact with race, gender, class, and other characteristics to sustain sexual violence. The movement also seems to pay little attention to the various ways the problematic patriarchal norms in Zambia are interwoven with women’s economic survival strategies.ConclusionOur findings suggest that rather than definitively establishing the MeToo movement as an incontestable good (as has been the case in most feminist literature) or as useless because it ignores economic and cultural realities as argued by its critics our findings instead demonstrate the diversity of how this movement is locally viewed by marginalized women in Zambia and also illustrates the nuance, complexity and multidimensionality of how the movement is characterized. In this regard, our findings speak to the folly of a ‘one-size-fits-all’ standardized universalization of the MeToo movement.
Efficacy of Artemisinin-lumefantrine for the treatment of uncomplicated malaria after more than a decade of its use in Kenya
Authors: Kishoyian Gabriel M. , Njagi Eliud N. M. , Orinda George O. , Kimani Francis T. , Thiongo Kevin , Matoke-Muhia Damaris
Published: April 2020

Background: Plasmodium falciparum resistance to antimalarial drugs remains to be a major threat to the control of malaria globally. After the deployment of artemisinin-based combination therapy (ACT), there have been reports of reduced sensitivity of the drug to parasite clearance. In Kenya, artemisinin-lumefantrine (AL) is the recommended first-line drug in the treatment of uncomplicated malaria. This study sought to assess the efficacy of AL after its reintroduction in Kenya, a decade later. In this study, we assessed clinical and parasitological responses of children under five years in May and November 2015 in Chulaimbo sub-County, Kisumu, Kenya.Method: Patients of ≥6 and ≤60 months of age with confirmed Plasmodium falciparum mono-infection were enrolled in the study. The patients were treated with a standard dose of AL and followed up for 28 days. During which period we monitored treatment responses and follow-up adherence.Results: Of the 90 patients enrolled, fourteen (14) were lost to follow-up, with 76 completing the study period. Seventy-five patients 75 (98.7%) cleared, parasitemia within 48 hours while one (1.3%) cleared on day 3. There was 100% clinical and parasitological parasite clearance. Conclusion: Artemisinin lumefantrine was found to be highly efficacious to plasmodium falciparum parasites in children aged ≥6 and ≤60 months. Based on this, the drug can be used to treat uncomplicated malaria in the study population. However, there is need for continued monitoring of its effectiveness in children and adults to counter the threat of resistance.
Large-Scale Metadata Analysis of Ovary Based Multi-Omics Datasets for Understanding the Genes Regulating Litter Size
Authors: Kameshwar Ayyappa Kumar Sista , Li Julang
Published: April 2020

Background : Litter size is a very important production index in the livestock industry, which is controlled by various complex physiological processes. To understand and reveal the common gene expression patterns involved in controlling prolificacy, we have performed a large-scale metadata analysis of five genome-wide transcriptome datasets of pig and sheep ovary samples obtained from high and low litter groups, respectively. We analyzed separately each transcriptome dataset using GeneSpring v14.8 software by implementing standard, generic analysis pipelines and further compared the list of most significant and differentially expressed genes obtained from each dataset to identify genes that are found to be common and significant across all the studies. Results : We have observed a total of 62 differentially expressed genes common among more than two gene expression datasets. The KEGG pathway analysis of most significant genes has shown that they are involved in metabolism, the biosynthesis of lipids, cholesterol and steroid hormones, immune system, cell growth and death, cancer-related pathways and signal transduction pathways. Of these 62 genes, we further narrowed the list to the 25 most significant genes by focusing on the ones with fold change >1.5 and p<0.05. These genes are CYP11A1, HSD17B2, STAR, SCARB1, IGSF8, MSMB, SERPINA1 , FAM46C, HEXA, PTTG1, TIMP1, FAM167B, CCNG1, FAXDC2, HMGCS1, L2HGDH, Lipin1, MME, MSMO1, PARM1, PTGFR, SLC22A4, SLC35F5, CCNA2, CENPU, CEP55, RASSF2, and SLC16A3 . Conclusions : Interestingly, comparing the list of genes with the list of genes obtained from our literature search analysis, we found only three genes in common. These genes are HEXA, PTTG1, and TIMP1. Our finding points to the potential of a few genes that may be important for ovarian follicular development and oocyte quality. Future studies revealing the function of these genes will further our understanding of how litter size is controlled in the ovary while also providing insight on genetic selection of high litter gilts.
Comparison of cyclopentolate versus tropicamide on corneal topography in emmetropic and myopic eyes
Authors: Sharif Nasrin Moghadas , Moghadam Hadi Ostadi , Azizi Elham , Ghoochani Elahe , Ehsaei Asieh
Published: April 2020

Background: To compare the effect of cyclopentolate versus tropicamide eye drops on anterior surface corneal parameters using Keratograph 4 in myopic and emmetropic individuals.Methods: Fifty-eight participants included 29 emmetropic and 29 myopic individuals, were recruited, according to inclusion and exclusion criteria. At baseline visit, anterior surface corneal parameters were measured using Keratograph 4 Keratograph 4in the right eye. All measurements were repeated at two separate visits, one week apart, after administration of tropicamide 1% and cyclopentolate 1% at similar conditions.Results: Of 58 participants who completed the study, 29 (24 women, 5 men, age: 23.82± 2.78 years) were emmetropic and 29 (21women, 8 men, age: 23.66± 2.76 years) were myopic. Baseline mean spherical equivalents were -0.23±0.23 D and -2.45±1.03 D in emmetropic and myopic groups, respectively. The analysis of the data showed a significant hyperopic shift following instillation of both cycloplegic eye drops in both refractive groups. However, tropicamide results was statistically insignificant in comparison with cyclopentolate (p=0.49). The assessment of data revealed no statistically significant differences in anterior surface corneal parameters in baseline, tropicamide and cyclopentolate instillation in each refractive group, except IHD value with tropicamide in myopic group (p=0.02). The further analysis between refractive groups also showed no significant differences in anterior surface corneal parameters in each session.Conclusions: Present study indicates that cyclopentolate and tropicamide do not appear to affect corneal topographic parameters and hence can be trusted to capture topography data.
Using triangular marks of capsulotomy edge for the alignment of Toric IOLs postoperation: a new technique
Authors: Wang Yong , Xue Ying , Li Panpan , Wu Jian , Guan Huaijin
Published: April 2020

Background: Accurate alignment of Toric intraocular lens (IOL) axis is vital for achieving the desired astigmatic correction after surgery. We used a pair of triangular incision markers on anterior capsulotomy edge to assess the rotations of Toric IOL axis and compare with conventional manual corneal marker for postoperative follow-up.Methods: Thirty-six cataract patients (39 eyes) were enrolled who underwent phacoemulsification and AcrySof Toric IOL implantation between May 2018 and August 2018. All patients coexist regular corneal astigmatism between 1.0 diopter(D) and 3.0D. The patients were divided to two groups according to the axial length. Axial length less than 26mm was named Group A. The other patients belong to Group B. Triangular incisions of anterior capsulotomy edge and conventional manual corneal marking method were used to measure the rotations of Toric IOL at 1 and 3 months after surgery.Results: The angels of rotation for Toric IOL assessed by the new markers were less at 1 and 3 months for group A when compared with the conventional manual corneal marking but not for group B. There are not any intraoperative and postoperative complications by using the new technique.Conclusion: The triangular markers in anterior capsulotomy edge are more accurate when compared with conventional manual corneal marking method to evaluate the rotation stability of Toric IOL after operation.
Text Mining and Predicting Disease-Gene-Drug Associations of Hypertension Data Cubes-Based
Authors: Wei Xing , Chang Xuelian , Wang Yanqiu , Xie Jing , Yang Xiaodi , Jiang Xiulin
Published: April 2020

Background Predispositions to hypertension is possibly associated with numerous potential gene polymorphisms and systemic disorders. Large-scale text mining of biomedical literature is a flexible and essential tool that can be applied to search for innovative drugs and treatments for diseases, such as investigating and predicting the bio-entities associations.Result We proposed a generality approach for extracting and predicting hypertension-related disease-gene-drug associations based on dictionary and data cube from biomedical abstracts. After data preprocessing, we constructed the 0-D vertex cube, which we then filtered to construct three 1-D cubes consisting of 252 diseases, 185 genes, and 141 drugs. By applying association rules to quantify the disease-gene-drug associations, we found 235 associations between 79 diseases and the 71 genes, and AUCs was 84.1%; 196 associations between 43 diseases and 102 drugs, and AUCs was 85.8%; 160 associations between 31 genes and 106 drugs, and AUCs was 83.6%. Using the bottom-up computation algorithm, we established three 2-D cubes and one 3-D disease-gene-drug cube, which revealed 591 associations between 90 diseases, 82 genes, and 145 drugs. Based on this 3-D cube, we obtained 262 predictive bio-entity association pairs of which 57 disease-drugs, 84 disease-genes, and 121 gene-drugs.Conclusions We have implemented and validated a data cube-based text mining approach to identifying and ranking the hypertension-related disease-gene-drug associations. Our results provide new pathways in the search for the potential treatment drugs of hypertension.
Coverage Rate of ADME Genes: Application to CYP2C8, CYP2D6 and CYP3A Genes for Personalized Chloroquine Treatment Against Coronavirus
Authors: Zaid Nabil , Khalki Loubna , Hadri Imane , Toughza Jihane , Badad Oussama , Sadki Khalid , Cheikh Amine , Limami Youness , Zaid Younes
Published: April 2020

Background: The latest studies have shown the effectiveness of Chloroquine against Coronavirus. However, since the tolerance and effectiveness of statistical data must be taken into account before proposing treatment to a patient, these promising results are often lacking.Since the CYP2C8, CYP2D6 and CYP3A Absorption, Distribution, Metabolism and Elimination (ADME) genes are involved in the drug response of Chloroquine, we are interested in studying the variations of these genes.Methods: The purpose of this study is to make a comparison between the various current genotyping and enrichment platforms, to know which of them allows the best coverage. Conclusions: This will allow us to carry out genome-wide association studies (GWAS) with the aim of finding new therapeutic targets against Coronavirus using Chloroquine.
Incidence rate and basic reproduction number of Coronavirus diseases (COVID-19): a systematic review and meta-analysis protocol
Authors: Gesesew Hailay Abrha , Mude William , Nyanhanda Tafadzwa , Mwanri Lillian
Published: April 2020

Background : World Health Organization declared Coronavirus (COVID-19) as a newly emerging disease on 31 December 2019. In a space of two-months, there have been several studies reporting incidence rates, incubation periods, fatality rates, basic and effective reproduction numbers of the disease. However, the data have not been synthesized and pooled together to determine the global average. Objective : The present study aims to systematically review available global evidence on incidence rates, and basic and effective reproduction numbers of COVID-19. Methods : This is a protocol for a systematic review of available quantitative studies published in English. Studies which describe the incidence rates, and basic and effective reproduction numbers of COVID-19 will be included in the search. Initially, search term concepts will be constructed through a preliminary search on Google scholar. Then, we will perform a full systematic search using the identified concepts in the following electronic bibliographic databases: SCOPUS, PubMed, Web of Sciences and CINAHL. Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) will be used to schematically present the full search strategy. Standardised Joanna Briggs Institute (JBI) quality appraisal and selection tools, and data extraction tools will be used to recruit studies and extract data from the included studies, respectively. Thematic analysis will be used to analyse the non-quantifiable data, and meta-analysis will be used to pool the quantitative information.
Prenatal diagnosis of fetal chromosomal abnormalities among 2318 pregnant women with indications in southern China: a retrospective study
Authors: Gu Xiaodong , Liu Sudong , Wang Huaxian , Weng Ruiqiang , Guo Xuemin , Zhong Zhixiong
Published: April 2020

Background

To investigate the frequency of fetal chromosomal abnormalities among women with abnormal ultrasound, abnormal biochemical marker screening or noninvasive prenatal testing results, advanced maternal age, or history of miscarriage in southern China.
Methods

We retrospectively analyzed prenatal samples from pregnant women between 2015 and 2019. Conventional karyotyping was performed using GTG banding. Copy number variation sequencing was used when indicated to identify chromosomal abnormalities.
Results

A total of 2,318 prenatal samples (188 chorionic villus samples, 2,003 amniotic fluids, and 127 cord blood) were analyzed. The frequency of chromosomal abnormalities was 12.4% (288/2,318) in prenatal samples, and frequency in chorionic villus samples (23.9%) was higher than in amniotic fluids (13.5%) and in cord blood (5.0%; P < 0.001). Numerical anomalies were detected in 195 (8.4%) cases and the most common abnormality were trisomy 21 (103/2,318; 4.4%), trisomy 18 (31/2,318; 1.3%) and monosomy X (18/2,318; 0.8%). Sructural anomalies were found in 29 (1.3%) cases, rare anomalies such as deletions (4 cases), duplications (2 cases), and complex rearrangement (1 case), were detected. Two cases with common chromosomal polymorphisms, inv(9)(p11q12) and inv(9)(p11q13), associated with recurrent spontaneous abortion, were detected. Five fetuses had normal karyotypes and definite pathogenic copy number variations, with microdeletions at 16p13.11, 16p12.1 (2 cases), and 17p12 and a microduplication at 7q11.23; all had normal phenotypes after birth.
Conclusion

Our study indicated that fetal chromosomal anomalies can be detected in early gestation and provided valuable information for interpretation of chromosomal polymorphisms and copy number variations.
Identification of TFEB gene genetic variants in acute myocardial infarction
Authors: Zhang Jie , Zhang Yexin , He Xiaohui , Wang Shuai , Pang Shuchao , Yan Bo
Published: April 2020

Background: Abnormal lipid metabolism and inflammation play critical roles in the initiation and progression of atherosclerosis and its associated complications, including coronary artery disease (CAD) and acute myocardial infarction (AMI). Autophagic-lysosomal system is involved in many physiological processes, such as lipid metabolism and inflammation. TFEB, a master regulator of the system, coordinates the expression of lysosomal hydrolases, lysosomal membrane proteins, and autophagic proteins. Altered level of TFEB gene expression and subsequent changes of autophagic-lysosomal system may be involved in the onset of CAD and AMI.Methods: In this study, the promoter of the TFEB gene was genetically and functionally analyzed in AMI patients (n=352) and ethnic-matched healthy controls (n=337).Results: A total of fifteen genetic variants, including eight single nucleotide polymorphisms (SNPs), were identified in the participants. Two novel genetic variants and four SNPs were only identified in six AMI patients, and significantly altered the transcriptional activity of the TFEB gene in cultured cells. Further electrophoretic mobility shift assay revealed that two genetic variants (g.41737144A>G and g.41736544C>T) and two SNPs [g.41737274T>C (rs533895008) and g.41736987C>T (rs760293138)] evidently affected the binding of transcription factors.Conclusions: Our findings suggested that the genetic variants in TFEB gene promoter may change TFEB levels, contributing to AMI as a low-frequency risk factor.
Effectiveness of No-Zone Approach for Management of Isolated Penetrating Neck Injuries Among Hemodynamically Stable Patients. A Longitudinal Retrospective Study.
Authors: Hassanein Ahmed Gaber , Elmoshneb Mohammed Hazem , Ahmad Wael A. , Aldardeer Ahmed Abdel Kahaar , Ismail Osama A.
Published: April 2020

Background: Routine neck exploration for isolated penetrating neck injuries (PNIs) in hemodynamically stable patients increases the frequency of nontherapeutic surgeries, and complications. Current management protocol involves the no zone approach which uses physical examination and computerized tomographic angiography to guide treatment plans. This work aimed to study the effectiveness and reliability of no-zone approach for management of isolated PNIs in hemodynamically stable patients. Methods: cases of isolated PNIs in hemodynamically stable patients were managed using no zone approach. Detected injuries were managed accordingly. Results: This study included 106 patients. 34.9% of patients were managed conservatively while surgery was done at 65.09%. Vascular management was done in 40.57%, laryngotracheal repair in 29.2%, tracheostomy in 17%, pharyngeal repair in 7.55%, esophageal repair in 6.6%, and accessory nerve repair in 2.83%. Complications occurred in 16.04% of cases in the form of vascular complications (7.5%), respiratory complications (5.7%), pharyngoesophageal complications (1.9%), infections (12.3%), and neurological complications (7.5%). The survivors were 91.5% while deaths were 8.5%. Conclusion: The no-zone approach offers the ideal management for isolated PNIs in hemodynamically stable patients. It is advantageous over traditional approaches. Further studies are required to augment the evidence for its use as the gold standard management for such cases. Trial registration: the study was retrospectively registered at research registry with Research Registry UIN researchregistry5385 on February 26, 2020. Keywords: no zone approach, isolated penetrating neck injuries, hemodynamically stable patients, vascular injuries, laryngotracheal injury.
The Safety and Therapeutic Effect Analysis of Intraoperative Intraperitoneal Chemotherapy with Lobaplatin for Hepato-Biliary-Pancreatic Cancer
Authors: Chen Gang , Chen Hao , Zhang Qifan , Zhang Siyun , Li Huanyu , Tan Qing , Zhou Jie , Zhu Bili , Wang Kai
Published: April 2020

Background

To examine the safeness and efficacy of intraoperative intraperitoneal perfusion chemotherapy with lobaplatin on hepato-biliary-pancreatic cancer.
Methods

Clinical data were retrospectively collected from a total of 66 patients with HBP cancer undertaken surgeries. They were divided into two groups: the study (lobaplatin) group (33 patients) and the control group (33 patients). The disease-free survival rate, postoperative complications, and chemotherapy side effects (bone marrow, liver, and kidney toxicity) were analyzed to examine the safeness and efficacy of intraoperative intraperitoneal chemotherapy with lobaplatin.
Results

In the study group, two patients had a postoperative subphrenic infection and increased peritoneal effusion, one patient had postoperative leukopenia and thrombocytopenia, while the control group had postoperative abnormal coagulation function in 1 patient, and gastrointestinal bleeding in 1 patient, no significant difference in postoperative complication was observed between the two groups. There was no significant difference in the liver and kidney function between the two groups after surgery (p > 0.05). A total of 26 patients in the two groups had recurrence or metastasis within one year after surgery, including eight patients in the study group and 18 patients in the control group. The recurrence rate of hepatocellular cancer in the lobaplatin group and control was 21.14% and 60%, respectively (P = 0.012 < 0.05). But there was no significant difference in the disease-free survival function analysis (P = 0.127 > 0.05).
Conclusions

Intraperitoneal perfusion chemotherapy with lobaplatin is a safe and effective treatment in the process of radical resection of hepato-biliary-pancreatic tumors, which has therapeutic potential in reducing postoperative tumor recurrence and metastasis.
The effect of extracellular matrix on myogenic induction of adipose mesenchymal stem cells
Authors: Fei Wenyong , xie bin , Liu Ying , Liu Mingsheng , Wang Xuanqi , Zhang Yao , Cao Shichao , Wang Jingcheng , Yan Lianqi , Pei Ming
Published: April 2020

Bankground: As one of the hot cells in the field of regenerative medicine, adipose mesenchymal stem cells(ADSCs) have been proved to have the ability of myoblast differentiation, but the disadvantage is that the efficiency of myoblast differentiation is not very high.Extracellular matrix(ECM), as a mixture of cytokines and proteins secreted by cells, is the substance secreted by cells. It has the advantages of non-toxic and harmless, and can provide the necessary material and environmental basis for cell growth and development.This study was to explore whether the myogenic differentiation potential of ADSCs cultured in ECM was improved.Method: ADSCs were extracted from subcutaneous fat of male SD rats at the age of 3 months and weight 250g. The third generation cellular of ADSCs were prepared for ECM，and the ECM was contained in the culture bottle for amplify the ADSCs. Myogenic induction was performed by 5-azacytidine using the same generation of ADSCs cultured with ECM and non-ECM.Result: ECM can significantly increase the rate of cell proliferation (P<0.05).Immunofluorescence detected the expression of β-actin, Myod and Desmin in cells ,and showed no significant difference in the expression of β-actin between groups (P>0.05). However, there were significant differences in Myod and Desmin between groups (P<0.001).RT-PCR showed that the mRNA expressions of myosin heavy chain(MHC), troponin, Myogein and Myf5 were significantly different among groups (P<0.001).Conclusion: ECM culture of ADSCs can improve its growth rate and myogenic differentiation potential.
Application of Electrospinning to SiC Fiber Synthesis
Authors: Hu Shao-Hwa , Dai Hang , Wu Li-Chun , Ai Ya-Zhao
Published: April 2020

Silicon carbide (SiC) possesses unique properties and is widely applied in household and military uses. This study explored the manufacturing process of SiC fibers. In the experiment, polycarbosilane (PCS) was dissolved in a mixed solvent of C8H10 and dimethylformamide (DMF) to form a solution, and electrospinning was employed to synthesize PCS fibers. PCS fibers underwent a curing process and a 2-h calcination at 1200°C in N2 atmosphere to convert PCS fibers into β-SiC fibers. The solute recruitment, solvent mixing ratio, and voltage in the experiment were defined as process parameters through which to examine the influence each parameter had on electrospinning. The PCS fibers were discovered to exhibit the most even size under the following condition: PCS recruitment of 1.0 g/ml, DMF constituting 30% of the solvent volume, voltage of 25 kV, spraying speed of 1.0 ml/h, and spinning distance of 15 cm. Under electron microscopy, the diameter of each PCS fiber was determined to be 1.0 μm, and the diameter of each β-SiC fiber was 0.8 μm.
Loop Based Design and Classification of Planar Scissor Linkages
Authors: Kiper Gökhan , Korkmaz Koray , Gür Şebnem , Müjde  , Maden Feray , Akgün Yenal , Karagöz Cevahir
Published: April 2020

Scissor linkages have been used for several applications since ancient Greeks and Romans. In addition to simple scissor linkages with straight rods, linkages with angulated elements were introduced in the last decades. In the related literature, two methods seem to be used to design scissor linkages, one of which is based on scissor elements, and the other is based on assembling loops. This study presents a systematic classification of scissor linkages as assemblies of rhombus, kite, dart, parallelogram and anti-parallelogram loops using frieze patterns and long-short diagonal connections. After the loops are multiplied along a curve as a pattern, the linkages are obtained by selection of proper common link sections for adjacent loops. The resulting linkages are analyzed for their motion and they are classified as realizing scaling deployable, angular deployable or transformable motion. Some of the linkages obtained are novel. Totally 10 scalable deployable, 1 angular deployable and 8 transformable scissor linkages are listed. Designers in architecture and engineering can use this list of linkages as a library of scissor linkage topologies.
Marija Brida i Roman Ingarden: dva fenomenološka »čitanja« Bergsonove koncepcije intuicije
Authors: Tićac Iris
Published: April 2020

Rad polazi od teze da je upravo fenomenološko iščitavanje Bergsonove koncepcije intuicije omogućilo Mariji Bridi i Romanu Ingardenu jedno diferenciranije tumačenje Bergsonove intuicije i to u jednom vremenu u kojemu je njegova misao bila neopravdano zanemarena. Pritom ni u kom slučaju ne sugeriramo da Brida i Ingarden čitaju Bergsona kao fenomenologa. Oboje nastoje pokazati u čemu se sastoji originalnost Bergsonove filozofije te pokazati relevantnost njegove koncepcije intuicije i za fenomenologijsku misao. Dok Bridu poglavito zanima kako izgleda stvaralaštvo, odnosno problematika stvaralačke slobode te s tim u svezi pored gnoseološkog i antropološko značenje intuicije, Ingarden se usredotočuje na propitivanje gnoseološkog značenja intuicije, odnosno posvećuje se traženju odgovora na upit o tome koje je značenje intuicije za spoznaju uopće.
Juraj Dragišić i kršćanski pisci u De natura caelestium spirituum quos angelos vocamus
Authors: Hrbud Natali
Published: April 2020

U dijalogu De natura caelestium spirituum quos angelos vocamus, objavljenom 1499. godine u Firenci, Juraj Dragišić spominje različite filozofske i teološke autore i njihova djela. Hrvatski znanstvenici u svojim radovima posvećenima Jurju Dragišiću spominju te autore i njihova djela (Martinović, Banić-Pajnić, Ćurko i dr.). Rad ima namjeru posvetiti veću pozornost kršćanskim autorima koje Dragišić koristi u svom dijalogu, po mogućnosti navesti većinu imena te pokazati koje od njih više spominje. Dakle, u radu se spominju i obrađuju, u kontekstu Dragišićeve rasprave o anđelima, uglavnom sljedeći kršćanski autori: Albert Veliki, Ambrozije, Anzelmo, Augustin, Beda, Boecije, Bonaventura, Pseudo-Dionizije Areopagit, Duns Skot, Grgur Nazijanski, Grgur Veliki, Henrik iz Ganda, Ivan Damaščanski, Ivan Zlatousti, Jeronim, Origen i Toma Akvinski. Navedeni se autori mogu podijeliti u dvije skupine: patrističke pisce i srednjovjekovne crkvene pisce.
Grčko-rimska filozofija u »Povijesti filozofije« Bonifaca Badrova
Authors: Tomić Draženko
Published: April 2020

Bonifac Badrov (Livno, 1896. – Sarajevo, 1974.), filozof neoskolastičkog usmjerenja, u »Povijesti filozofije« (Sarajevo, 1959.), priručniku za studente na Franjevačkoj teologiji u Sarajevu, povijest filozofije definira kao sustavan prikaz rješavanja filozofskih problema u različitim razdobljima i kritičko istraživanje njihove unutarnje dinamike. Sagledavajući ovaj, inače pregledan i informativan, jasno strukturiran, uravnotežen i zacrtanom cilju usmjeren tekst, ne bi valjalo smetnuti s uma da njegova »Povijest filozofije« nije napisana za stručnjake nego za studente sasvim određenog tipa, s punom sviješću da se neki od njih tek upoznaju s ovim filozofijom i da ga sukladno sustavu obrazovanja u teološkim učilištima slušaju usporedo sa skolastičkom filozofijom. Uz to na umu valja imati i autorovu neoskolastičku filozofsku orijentaciju, kao i dometnuti da u ovom djelu religiozni aspekt nije naglašen nego autor tek informira onoliko koliko je potrebno o stavu nekog filozofa o Bogu i božanskom. Rad se bavi grčko-rimskom filozofijom i prema Bradovljevoj strukturi nudi pregled razvoja grčko-rimske filozofije u tri periode s tri temeljna obilježja: kozmološko kod predsokratovaca s izrazitim (materijalističkim) monizmom, evolucionizmom, hilozoizmom, panteizmom, antiintelektualizmom i konačno naturalizmom, metafizičko u razdoblju antike s izraženim subjektivizmom, relativizmom, agnosticizmom (sofisti), etikom i monoteizmom (Sokrat) i dualizmom na svim područjima (Platon) odnosno metafizikom (Aristotel) i konačno etičko u razdoblju helenizma. U radu se u prvom planu nalazi Badrovljeva kritika filozofa ili filozofskih sustava dok su povijesni podaci o istima stavljeni po strani. Za neke filozofe je navedeno gdje se pojavljuju u drugim njegovim djelima.
Heideggers Radikalisierung der kantischen Lehre von den mathematischen Schemata und der Zeit
Authors: Radovanović Biljana , Ružić Goran
Published: April 2020

Osnovni motiv Heideggerova tumačenja Kantove teorijske filozofije sastoji se u tome da se pokaže da Kantovo učenje o shematizmu i vremenu predstavlja tek pred-stupanj problematike temporalnosti. U tom kontekstu analizirat ćemo Heideggerovu tezu o transcendentalnoj uobrazilji kao »izvoru« vremena, odnosno matematičke sheme vremenskog niza i vremenskog sadržaja. S obzirom na to da su ove sheme nužnim načinom povezane s kategorijama kvantitete i kvalitete, kao i s načelima (sintetičkim stavovima a priori) čistog razuma koja je Kant formulirao kao »aksiome zrenja« i »anticipacije opažaja«, jasno je da je time naš interpretativni zadatak postao složeniji. Paralelno s navedenim, morali smo dovesti u vezu jedinstvo vremena (kao formalnog zora) s jedinstvom praosnovne apercepcije (strukture samosvijesti), kao i čulno danu mnogostrukost s vremenom kao formom čistog čulnog zora. Usporedna analiza A i B izdanja Kantove Kritike čistog uma omogućila nam je, preko Heideggerovih predavanja i studija, da unutar Kantova teksta sagledamo mogućnosti »ontologizirane« i fenomenološki usmjerene interpretacije i tumačenja osnovnih postavki Kantove »teorije spoznajnog subjekta«.
El trastorno afectivo bipolar es una expresión narcisista y melancólica/maníaca en psicodinámica
Authors: Ángel Gómez Karen
Published: April 2020

El Trastorno Afectivo Bipolar (TAB) es una enfermedad mental que se ha adueñado de la salud de todo tipo de personas desde todos los lados y países del mundo. Por eso es de gran importancia, como profesionales de la salud mental de cualquier enfoque o rama, comprender cómo se inicia, se desarrolla y se expresa el TAB en la vida de los seres humanos. En este ensayo se pretende, a través de una revisión teórica, explicar desde una perspectiva psicodinámica esta condición y argumentar que puede surgir no solo por lo genético, sino que también se considera que puede ser una expresión de la estructuración narcisista en las relaciones objetales internalizadas y del duelo patológico explicado por Freud en su obra Duelo y Melancolía de 1917, en donde se especifican la melancolía y la manía como síntomas claves en el TAB. Cabe señalar que fue importante hacer una integración de conceptos psicoanalíticos, psicodinámicos y también clínicos para explicar y entender una problemática mundial de la salud mental como lo son las enfermedades mentales, especialmente el TAB.
Violencia filio-parental, una reflexión en construcción
Authors: David Piedrahita Deisi Yojana , Ramírez Solarte Laura Marcela
Published: April 2020

En el presente trabajo se busca cavilar acerca de la violencia filio-parental, como parte de una realidad que, desde una mirada en referencia a las ciencias sociales y humanas, amerita una reflexión, una intervención y un espacio para dar a conocer por qué ocurre la dinámica de violencia de hijos a padres, y a hoy cuáles han sido los diferentes abordajes en cuanto al concepto de familia, razón por la cual se hace necesario emprender un conocimiento en lo que implica las peculiaridades que comprenden las familias en su interior, el fenómeno de la violencia filio-parental y su posible intervención. Esta investigación documental se realizó con base en un enfoque hermenéutico, donde a partir de los hallazgos, se pretende analizar, comprender e interpretar la realidad de la violencia filio-parental desde diferentes autores que apuntan al tema de investigación, logrando concebir de manera clara cuál es la dinámica que se ejerce dentro de la familia. Se divide entonces en tres partes: descripción, identificación e intervención, desde las dinámicas internas de las familias, partiendo de las clasificaciones que existen de violencia familiar, logrando resignificar el lugar que tiene la familia en la sociedad; por último, se recogen algunas reflexiones en referencia a la intervención de la violencia filio-parental.
Rural Male-Out-Migration and Its Dynamic Links with Native Villages: A Study of Selected Villages of Rarh Region of West Bengal, India
Authors: Debnath Manoj , Ray Sheuli
Published: April 2020

Bankura district is drought-prone in nature from where rural people regularly migrate to the nearby agriculturally and economically developed districts. In the paper, regional pattern, nature, distance, duration, mechanism of this rural male-out-migration and linkages of migrants with the native villages have been analyzed. The study is primarily conducted on the basis of information collected from door to door survey through a structured questionnaire. These collected data indicate that the landless people, especially from drought-affected villages, experience a higher proportion of out-migration. They normally migrate during the absence of agricultural activities at their native villages and a large portion of these migrants also return to their village during the short agricultural season. It is also found that the frequency of visiting the native village has an inverse relation with distance. Those who regularly visit their native village, most of them move from a short distance.
Evaluation of temporal drought variation and projection in a tropical river basin of Kerala
Authors: Jincy Rose M. A. , Chithra N. R.
Published: April 2020

Temperature is an indispensable parameter of climate that triggers evapotranspiration and has vital importance in aggravating drought severity. This paper analyses the existence and persistence of drought conditions which are said to prevail in a tropical river basin which was once perennial. Past observed data and future climate projections of precipitation and temperature were used for this purpose. The assessment and projection of this study employ the Standardized Precipitation Evapotranspiration Index (SPEI) compared with that of the Standardized Precipitation Index (SPI). The results indicate the existence of drought in the past and the drought conditions that may persist in the future according to RCP 4.5 and 8.5 scenarios. The past drought years identified in the study were compared with the drought declared years in the state and were found to be matching. The evaluation of the future scenarios unveils the occurrence of drought in the basin ranging from mild to extreme conditions. It has been noted that the number of moderate and severe drought months has increased based on SPEI compared to SPI, indicating the importance of temperature in drought studies. The study can be considered as a plausible scientific remark helpful in risk management and application decisions.
Configuración económica de Baja California
Authors: García Montaño Jorge
Published: April 2020

Este estudio tiene como finalidad realizar una comparación entre la economía de Baja California con la del resto del país, tomando en cuenta los cambios que han sufrido las actividades  económicas del estado.También se plantea que Baja California, por su situación geográfica, desarrolla un modelo de crecimiento diferente al resto del país, haciendo hincapié en los factores que se encuentran relacionados con la economía internacional
Población flotante: Tipología de visitantes en Tijuana
Authors: Bringas Rábago Nora L. , Woo Morales Ofelia
Published: April 2020

Desde los inicios del presente siglo, el desarrollo de Tijuana ha sido marcado por el turismo nacional y extranjero. El objetivo de este trabajo es establecer una tipología de los visitantes que llegan a esta ciudad, a partir de los servicios que demandan, enfocando la atención en los turistas extranjeros y los migrantes en sus diferentes modalidades.Se hará referencia específica a los migrantes que han llegado a esta frontera con la esperanza de emigrar hacia Estados Unidos, y que se ven en la necesidad de permanecer en la ciudad y hacer uso de diversos servicios, principalmente hospedaje y alimentación
Perspectivas de integración energética México- norteamericana: Intercambios de electricidad y gas natural en el noroeste mexicano
Authors: Sández Pérez Agustín
Published: April 2020

Históricamente, la relación comercial México-norteamericana en el plano energético ha sido hegemonizada por el intercambio de hidrocarburos. En épocas de conflagración mundial, y más recientemente de conflictos bélicos en el Medio Oriente, el acceso preferencial a este recurso ha representado un factor importante de tensión para México. Fuera de las etapas de tensión, tal intercambio continúa siendo eje de la negociación comercial y aún más lejos, ha llegado a ocupar en algunos periodos un rol clave en la planeación económica global de la nación. Esta relación abrumadora, que parece privilegiar a toda costa el examen del intercambio petrolero en la relación comercial bilateral es, en cambio, ajena y distante al panorama social y productivo de la frontera norte y muy especialmente del noroeste mexicano. En éste, el intercambio energético se circunscribe hoya la venta de electricidad hacia el norte y la venta de gas natural hacia el sur de la frontera entre ambos países. El seguimiento de los circuitos eléctricos interconectados entre Baja California y California es un proceso relativamente reciente. Hacia mediados de los ochenta se realizaron las negociaciones entre autoridades y representantes de ambos países. Esta negociación reflejó, a su vez, la disparidad organizacional de la producción eléctrica. Más recientemente se han establecido programas y políticas destinadas al uso eficiente de la energía. A la vez se presencian procesos paralelos de gran trascendencia. Una de las alternativas que se discuten hoy para el abatimiento de costos de producción es la utilización del gas natural como alimento de la termoelectricidad a fin de sostener la capacidad instalada y asegurar la exportación.
Biomarkers of Acromegaly and Growth Hormone Action
Authors: Maffezzoni Filippo , Porcelli Teresa , Delbarba Andrea , Pezzaioli Letizia , Cappelli Carlo , Ferlin Alberto
Published: April 2020

:

Biological markers (biomarkers) play a key role in drug development, regulatory approval
and clinical care of patients and are linked to clinical and surrogate outcomes.

:

Both acromegaly and Growth Hormone Deficiency (GHD) are pathological conditions related to
important comorbidities that, in addition to having stringent diagnostic criteria, require valid markers
for the definition of treatment, treatment monitoring and follow-up. GH and insulin-like growth
factor-I (IGF-I) are the main biomarkers of GH action in children and adults while, in acromegaly,
both GH and IGF-I are established biomarkers of disease activity.

:

However, although GH and IGF-I are widely validated biomarkers of GHD and acromegaly, their
role is not completely exhaustive or suitable for clinical classification and follow-up. Therefore,
new biological markers for acromegaly and GH replacement therapy are strongly needed.

:

The aim of this paper is to review and summarize the current state in the field pointing out new
potential biomarkers for acromegaly and GH use/abuse.
Proteomic Investigations to Assess the Impact of Salinity on Vigna radiata L. Genotypes
Authors: Alharby Hesham F. , Hakeem Khalid Rehman
Published: April 2020

Background:

In our previous study, six cultivars of Mungo (Vigna radiata) were exposed
to 100-250 mM NaCl and studied for changes in growth and biomass. Among them,
AEM-96 cultivar of the Mung bean [Vigna radiata (L.) Wilczek cv.] was found to tolerate NaCl
stress at 250 mM.

Objective:

The soluble proteome of salt-tolerant mungo cultivar (AEM-96) was compared to the
proteome of control mungo to investigate the possible mechanism of salinity tolerance.

Methods:

Gel-based two-dimensional gel electrophoresis was employed for comparative proteomics.
PDQuest-based image analysis of 2D SDS-PAGE was performed. Scatter plots were prepared
and total spots were analyzed for 2-fold changes in abundance of protein spot intensities in
control and treated gels.

Results:

In total 517 protein spots were detected; 36 with high significance. Among these 36 spots,
2-fold expression change was analyzed in 27 protein spots. Seven protein spots were upregulated,
eight spots were down-regulated, 3 spots were newly induced and 9 spots were silenced, while 9
protein spots did not change their 2-fold abundance under salinity. Protein spots (9 in total) which
were 2-fold upregulated and newly induced were excised from the respective gels. The spots were
tryptically digested and run on LC-MS/MS for generating peptides and performing a comparative
fingerprinting of the proteins. The peptide signal data was loaded on the Mascot (Swissprot)
database to retrieve protein IDs. Proteins with the best score were selected, namely isomers of oxygen-
evolving enhancer protein 1 (S1-S3), RuBisCO (S4), oxygen-evolving enhancer protein 2
(S5), Heat shock protein 70 isomers (S6-S7), RuBisCO activase (S8), rubber elongation factor (S9)
and pathogen-related protein 10 (S10).

Conclusion:

The identified proteins were found to play important roles in photosynthesis, stress response
and plant growth.
Multi-level Parallelization of Genotype Imputation on Supercomputers
Authors: Zhang Weiwen , Wang Long , Aye Theint Theint , Samsudin Juniarto , Zhu Yongqing
Published: April 2020

Background:

Genotype imputation as a service is developed to enable researchers to estimate
genotypes on haplotyped data without performing whole genome sequencing. However, genotype
imputation is computation intensive and thus it remains a challenge to satisfy the high performance
requirement of genome wide association study (GWAS).

Objective:

In this paper, we propose a high performance computing solution for genotype imputation
on supercomputers to enhance its execution performance.

Method:

We design and implement a multi-level parallelization that includes job level, process level
and thread level parallelization, enabled by job scheduling management, message passing interface
(MPI) and OpenMP, respectively. It involves job distribution, chunk partition and execution,
parallelized iteration for imputation and data concatenation. Due to the design of multi-level
parallelization, we can exploit the multi-machine/multi-core architecture to improve the performance
of genotype imputation.

Results:

Experiment results show that our proposed method can outperform the Hadoop-based
implementation of genotype imputation. Moreover, we conduct the experiments on supercomputers to
evaluate the performance of the proposed method. The evaluation shows that it can significantly
shorten the execution time, thus improving the performance for genotype imputation.

Conclusion:

The proposed multi-level parallelization, when deployed as an imputation as a service,
will facilitate bioinformatics researchers in Singapore to conduct genotype imputation and enhance
the association study.
Exercise and Stevia Rebaudiana (R) Extracts Attenuate Diabetic Cardiomyopathy in Type 2 Diabetic Rats: Possible Underlying Mechanisms
Authors: Hussein Abdelaziz M. , Eid Elsayed A. , Bin-Jaliah Ismaeel , Taha Medhat , Lashin Lashin S.
Published: April 2020

Background and Aims:

In the current work, we studied the effects of exercise and stevia
rebaudiana (R) extracts on diabetic cardiomyopathy (DCM) in type 2 diabetic rats and their possible
underlying mechanisms.

Methods:

: Thirty-two male Sprague Dawley rats were randomly allocated into 4 equal groups; a) normal
control group, b) DM group, type 2 diabetic rats received 2 ml oral saline daily for 4 weeks, c)
DM+ Exercise, type 2 diabetic rats were treated with exercise for 4 weeks and d) DM+ stevia R extracts:
type 2 diabetic rats received methanolic stevia R extracts. By the end of the experiment, serum
blood glucose, HOMA-IR, insulin and cardiac enzymes (LDH, CK-MB), cardiac histopathology, oxidative
stress markers (MDA, GSH and CAT), myocardial fibrosis by Masson trichrome, the expression
of p53, caspase-3, α-SMA and tyrosine hydroxylase (TH) by immunostaining in myocardial tissues
were measured.

Results:

T2DM caused a significant increase in blood glucose, HOMA-IR index, serum CK-MB and
LDH, myocardial damage and fibrosis, myocardial MDA, myocardial α-SMA, p53, caspase-3, Nrf2
and TH density with a significant decrease in serum insulin and myocardial GSH and CAT (p< 0.05).
On the other hand, treatment with either exercise or stevia R extracts significantly improved all studied
parameters (p< 0.05). Moreover, the effects of stevia R was more significant than exercise (p< 0.05).

Conclusion:

Both exercise and methanolic stevia R extracts showed cardioprotective effects against
DCM and Stevia R offered more cardioprotective than exercise. This cardioprotective effect of these
lines of treatment might be due to attenuation of oxidative stress, apoptosis, sympathetic nerve density
and fibrosis and upregulation of the antioxidant transcription factor, Nrf2.