bluuebunny/crossref_metadata_2025 huggingface dataset:
Increase in antibody titers from H5N1 vaccine confers cross-protection against highly pathogenic H5N1 influenza virus
Authors: Zhao Chenyan , Huang Xiande , Yu Dan , Pan Ling , Wu Xi , Li Jun , Huang Weijin
Published: December 2024

H5N1 is a highly pathogenic avian influenza (HPAI) virus that has exhibited a significant capacity for adaptation and transmission among diverse mammalian species, thereby raising concerns regarding its pandemic potential. Vaccination constitutes a crucial strategy for controlling the spread of HPAI, rendering the development of effective vaccines and treatments for H5N1 a paramount public health priority. In 2005, Sinovac Biotech Ltd., China, developed an inactivated H5N1 vaccine with an aluminum hydroxide adjuvant, employing the A/Vietnam/1194/2004 (clade 1) strain for potential influenza pandemics or emergencies. However, the neutralizing efficacy of this vaccine against currently circulating H5N1 strains, especially those of clade 2.3.4.4b, remains uncertain. In the present study, a pseudovirus platform and clinical human immune sera from H5N1 vaccine recipients were utilized to assess the neutralizing antibody responses to globally circulating H5N1 strains, focusing on the antigenic match between the vaccine strain and circulating strains. The results indicate that sera from participants who received two doses of the H5N1 vaccine with aluminum hydroxide adjuvant manifested broad-spectrum protective effects against H5N1 strains only when high antibody titers were attained. By analyzing the correlation between pseudovirus-based neutralizing assay (PBNA) titers and seroconversion rates (SCR) against H5N1 strains, it was estimated that a PBNA titer of at least 1:980 is required to achieve a cross-protection rate above 60%. The findings suggest that with increased antibody titers, China’s H5N1 vaccine is capable of generatingcross neutralizing antibodies against H5N1 strains. Until new H5N1 vaccines are developed, measures such as using a more efficacious adjuvant, increasing the number of doses, or adjusting the dosage could enhance antibody titers, enabling this vaccine to function as a bridging measure to prevent further outbreaks of HPAI.
Mosaic integration of spatial multi-omics with SpaMosaic
Authors: Chen Jinmiao , Yan Xuhua , Ang Kok Siong , Olst Lynn van , Edwards Alex , Watson Thomas , Zheng Ruiqing , Fan Rong , Li Min , Gate David
Published: December 2024

With the advent of spatial multi-omics, we can mosaic integrate diverse datasets with partially overlapping modalities to construct consensus multi-modal spatial atlases of the source tissue. SpaMosaic is a spatial multi-omics mosaic integration tool that employs contrastive learning and graph neural networks to construct a modality-agnostic and batch-corrected latent space suited for analyses like spatial domain identification and imputing missing omes. Using simulated and experimentally acquired datasets, we benchmarked SpaMosaic against single-cell multi-omics mosaic integration methods. The experimental data encompassed RNA and protein abundance, chromatin accessibility or histone modifications, acquired from brain, embryo, tonsil, and lymph node tissues. SpaMosaic achieved superior performance over existing methods in identifying known spatial domains with enhanced resolution and clarity while reducing noise and batch effects. It also ranked top for modality alignment, enabling seamless diagonal integration without the need for image registration. After integration, SpaMosaic can also impute missing modalities. With a mosaic set of mouse brain data with RNA and different epigenomic modalities, we integrated and imputed the missing omics. There we found the imputed gene activity scores of activating and silencing histone marks show the correct correlation with RNA. Moreover, we uncovered more region-specific genes and pathways showing the correct transcriptome-epigenome correlations in the imputed histone modification than in the measured chromatin accessibility modalities. Lastly, SpaMosaic’s imputation also allows the inference of relationships between different modalities without requiring co-profiling from the same section.
Multi-purpose enzyme-substrate interaction prediction with progressive conditional deep learning
Authors: Nie Zhiwei , Zhang Hongyu , Jiang Hao , Liu Yutian , Huang Xiansong , Xu Fan , Tian Yonghong , Chen Jie , Zhang Wen-Bin
Published: December 2024

Understanding and modeling enzyme-substrate interactions is crucial for designing enzymes with tailored functions, thereby advancing the field of enzyme engineering. The diversity of downstream tasks related to enzyme catalysis calls for a computational architecture that actively perceives enzyme-substrate interaction patterns to make unified predictions for multiple objectives. Here, we introduce MESI, a progressive conditional deep learning framework for multi-purpose enzyme-substrate interaction prediction. By decomposing the modeling of enzyme-substrate interactions into a two-stage process, MESI incorporates two conditional networks that respectively emphasize enzymatic reaction specificity and crucial catalytic interactions, facilitating a gradual shift in the feature latent space from the general domain to the catalysis-aware domain. Across various downstream tasks, MESI consistently outperforms state-of-the-art methods on top of a unified architecture. Furthermore, the proposed conditional networks implicitly capture the fundamental patterns of enzyme catalysis with negligible additional computational overhead, as evidenced by extensive ablation experiments. With the support of this conditional perception mechanism, MESI enables cost-effective and accurate identification of active sites without requiring any structural information, highlighting enzyme residues and substrate functional groups involved in diverse and critical catalytic interactions. Overall, MESI represents a unified prediction paradigm for downstream tasks related to enzyme catalysis, paving the way for deep-learning-based catalytic mechanism cracking and enzyme engineering with strong generalization and interpretability.
CircCAMSAP1 Suppresses Uveal Melanoma Progression via miR-1182 Sponging and NONO Regulation
Authors: Wu wencan , Sun Lan-Fang , Liao Qianling , Wang Ya-Nan , Yu Bo , Wu Ende , Wei Jinfei , Ke Xiaoyu , Liu Xiaojiang , Pan Zhaoqi , Yu Zhonghao , Gu Jiayi , Yan Wentao , Tu Yunhai
Published: December 2024

Uveal melanoma (UM) is an extremely aggressive tumor with an unfavorable prognosis and few therapeutic options. Understanding the critical molecular regulators in UM is essential to improving treatment. Circular RNAs (circRNAs) have recently been recognized as pivotal regulators in cancer, although their roles in UM remain largely unexplored. Here, it was found that circCAMSAP1 was significantly downregulated in UM tissues and cell lines. CircCAMSAP1 was observed to act as a sponge for miR-1182, modulating NONO expression to reduce cell proliferation and induce apoptosis. Clinical analysis showed that patients with high NONO levels had significantly better prognoses. Additionally, bioinformatics analysis of circCAMSAP1-overexpressing cells revealed its association with MAPK signaling pathway. The findings suggest the potential of circCAMSAP1 as a biomarker and target for diagnosing and treating UM, offering new avenues for improving patient outcomes.
Face Your Fears: Virtual reality-based cognitive behavioral therapy (VR-CBT) versus standard CBT for paranoia in patients with schizophrenia spectrum disorders: Results of a randomized clinical trial
Authors: Glenthøj Louise , Vernal Ditte , Due Anne Sofie , Mariegaard Lise , Pinkham Amy , Austin Stephen , Vos Maarten , Christensen Mads , Hansen Nina , Smith Lisa , Hjorthøj Carsten , Veling Wim , Nordentoft Merete , Jeppesen Ulrik
Published: December 2024

Paranoia is a distressing and prevalent symptom in schizophrenia spectrum disorders (SSD). This assessor-masked, randomized parallel group superiority trial investigated the efficacy of virtual reality-based cognitive behavioral therapy (VR-CBT) compared to standard CBT targeting paranoia. A total of 259 participants with SSD and paranoia were randomized to receive 10 sessions of VR-CBT or standard CBT, excluding five who later withdrew informed consent. Intention-to-treat analyses included 254 participants (VR-CBT: n = 126, standard CBT: n = 128). Outcomes were assessed at baseline, treatment cessation (3 months) and follow-up (9 months). The primary outcome was the Green Paranoid Thought Scale (GPTS) subscale Ideas of Persecution, measured at treatment cessation. Linear mixed-model analyses revealed no statistically significant difference between the groups at endpoint (adjusted mean difference 1.12, 95% CI: -1.75 to 3.99 Cohen’s d=0.10; p=0.44). Both groups demonstrated large with-in group improvements on the primary outcome (VR-CBT: Cohen’s d=0.88; standard CBT: Cohen’s d=0.87). No deaths or violent incidents involving law enforcement occurred during the study. These findings do not support the superiority of VR-CBT over standard CBT; rather, both interventions significantly reduced paranoia and represent promising treatment options for SSD-related paranoia.
ClinicalTrials.gov identifier NCT04902066.
Wie wir Kindern den Krieg erklären
Authors: Bauer Angela , Stoeck Janine
Published: December 2024

Erklärvideos für Kinder und Jugendliche werden in den letzten Jahren zunehmend relevanter. Im Zuge von Mediatisierung und Digitalisierung verbreiterte sich das Angebot an Erklärvideos für spezifische Adressat:innengruppen. Erklärvideos nahmen in diesem Zuge auch im Rahmen von Bildungs- und Aneignungsprozessen in der (schulischen) Lebenswelt von Kindern und Jugendlichen einen festen Platz ein (MPFS 2022, 36f.). Bislang ist noch offen, welcher Logik diese Angebote folgen und wie sie sich als Forschungsgegenstand konstituieren. Der vorliegende Beitrag knüpft hier an und widmet sich aus einer erziehungswissenschaftlichen Perspektive den pädagogischen Implikationen. Entlang der Analyse erster Befunde einer explorativ-empirischen Studie zu krisenbezogenen Erklärvideos zum Ukraine-Krieg, in der ausgewählte Text- und Bildelemente exemplarisch nach der Objektiven Hermeneutik interpretiert wurden, wird vorgestellt, was in diesen Videos implizit zum Ausdruck gebracht wird. Mit Blick auf den Bedeutungszusammenhang für die Rezipient:innen lässt sich überlegen, welchen Spielraum die herausgestellten Inszenierungen von Erklärungen für die Selbsterprobung und Weltdeutung (Bildung eines Selbst- und Weltverhältnisses) von Kindern bereitstellen und welche Antwort sie auf Krisenphänomene geben.
ТЕОРИЯ ПРОВОЦИРОВАНИЯ М. М. БАХТИНАОТ САМОРАСКРЫТИЯ К ДИАЛОГУ
Authors: Сычев А.А.
Published: December 2024

В статье прослеживается эволюция понятия «провоцирование» от литературоведческого неологизма до философской категории с глубинными эпистемологическими и онтологическими смыслами. Показано, что это понятие первоначально применялось М.М. Бахтиным для обозначения системы приемов, при помощи которых Ф.М. Достоевский побуждает своих героев к самораскрытию. В поздних работах Бахтин видит в провоцировании побуждение к диалогу: человеческая жизнь для него есть диалогический ответ на провоцирующие факторы. Термин «провоцирование» применим и к творчеству Бахтина, мысль которого избегает центра и концентрируется на периферийных смыслах. Эксцентрический взгляд позволяет задать дистанцию по отношению к идее и представить бесконечное число ракурсов ее рассмотрения, окончательно не оформляя ее.

The article traces the evolution of the concept of provocation in the works of Mikhail Bakhtin: from the literary neologism to the philosophical category with profound epistemological and ontological meanings. It is shown that this concept was originally used by Bakhtin to denote the system of tools which helped Fyodor Dostoyevsky to make his characters disclose themselves. In his later works Bakhtin sees in provoking a stimulus for dialogue: human life is a dialogical response to provoking factors. Moreover, the term “provocation” is applicable to Bakhtin's works, whose thought is concentrated on the meanings existing not in the center, but on the periphery. This eccentric view allows to set a distance in relation to the central idea and propose an infinite number of views about it, without formulating it.
ИСТОРИЯ, ВЛАСТЬ И ИДЕОЛОГИЯВ СТАЛИНСКУЮ ЭПОХУ
Authors: Холматов Т.К.
Published: December 2024

Рец. на кн.: Дубровский А.М. Власть и историческая мысль в СССР (1930-1950-е гг.) (М.: Политическая энциклопедия, 2017. 622 с.); Тихонов В.В. Идеологические кампании «позднего сталинизма» и советская историческая наука (середина 1940-х – 1953 г.) (М.; СПб.: Нестор-История, 2016. 424 с.).

Reviews: A.M. Dubrovskiy, Power and historical thought in USSR (1930s – 1950s) (Moscow, 2017. 622 p.) and V.V. Tikhonov, Ideological campaigns of “late Stalinism” and Soviet historical science (mid 1940’s – 1953) (Moscow; Saint-Petersburg, 2016. 424 p.).
КРИТИЧЕСКИЕ ИССЛЕДОВАНИЯ ТЕРРОРИЗМА ИАНТРОПОЛОГИЯ НАСИЛИЯ
Authors: Игаева К.В.
Published: December 2024

Статья представляет обзор «критических исследований терроризма» (CTS) – междисциплинарного направления, возникшего в 2000-е гг. на стыке философии, политологии, истории с целью проблематизировать природу терроризма и его эволюцию в новейшее время. Отталкиваясь от критической теории и постструктурализма М. Фуко, сторонники CTS анализируют механизмы конструирования границы между государственной политикой террора, колониальными восстаниями и широким спектром явлений «нового терроризма», экотерроризма, кибертерроризма, контртеррористическими и миротворческими операциями. Для понимания этого направления особенно репрезентативной представляется «Антология критических исследований терроризма» (2016). Ее анализ позволяет обозначить перспективы CTS, а также внутренние противоречия и теоретические разногласия их сторонников.

The article provides an overview of the "critical terrorism studies" (CTS), an interdisciplinary field of research that was formed in the 2000s. at the intersection of philosophy, political science, and history. The goal of its followers is to problematize the nature of terrorism and its evolution in the XX c. Starting from the critical theory and poststructuralism of Michel Foucault, CTS analyze the mechanisms for constructing the border between the state policy of terror, colonial uprisings, as well as a wide range of "new terrorism" phenomena, ecoterrorism, cyberterrorism, counterterrorism and peacekeeping operations. Especially representative for understanding this new line of research is the "Routledge Handbook of Critical Terrorism Studies" (ed. R. Jackson, 2016). Its analysis allows us to outline the prospects of CTS, as well as the internal contradictions and theoretical differences of its supporters.
Круглый стол: ИДЕЯ ИСТОРИИ В ЕВРОПЕЙСКОЙИНТЕЛЛЕКТУАЛЬНОЙ КУЛЬТУРЕ XVI–XVIII вв.
Authors: Серегина А.Ю.
Published: December 2024

Обзор круглого стола «Идея истории в европейской интеллектуальной культуре XVI–XVIII вв. Памяти Констанс Блэквелл» (28 ноября 2018 года), организованного Центром интеллектуальной истории и Отделом историко-теоретических исследований Института всеобщей истории РАН.

Overview of the round table “The idea of history in European intellectual culture of the XVI–XVIII cс. In memory of Constance Blackwell ”(November 28, 2018), organized by the Center for Intellectual History and the Department of Historical and Theoretical Research of the Institute of General History (Russian Academy of Sciences).
Semeando conhecimento: popularizando informações sobre a conservação das sementes crioulas
Authors: SILVA Samuel Borges Sousa , ALENCAR Mariany de , COSTA Lenilson Joaquim da , SANTOS Thais Ferreira , SILVA Joana Maria Leal , SILVA José Rodrigues da , SANTOS Michelli Ferreira dos
Published: December 2024

As sementes crioulas são essenciais para garantir a soberania alimentar das populações do campo que as cultivam e conservam. Assim, o presente trabalho teve como objetivo utilizar de meios de comunicação, como a rádio e o Instagram, como estratégias para disseminar o conhecimento sobre a conservação das sementes crioulas. O projeto atingiu cerca de 500.711 pessoas. Além disso, os conteúdos foram compartilhados com os seguidores da página do Instagram do Grupo de Pesquisa em Sementes Crioulas do Piauí – GPESC – (@gpesc_ufpi), alcançando 711 pessoas. Os assuntos abordaram informações técnicas, cientificas e culturais, que auxiliam os campesinos no seu cotidiano. Portanto, a tecnologia permitiu o aumento da popularização da informação sobre a conservação das sementes crioulas ao interligar o projeto de extensão, com a rádio e o Instagram, às comunidades rurais e urbanas.
The influence of social media marketing on customer knowledge management: The role of confidentiality in UAE public banks
Authors: Awad Abdelrehim , Moustafa Aldabousi Ahmed , Albatal Seham
Published: December 2024

Social media facilitates banks’ interaction with consumers and provides critical information about their behaviors and preferences. Nevertheless, given the sensitive nature of financial information, maintaining stringent confidentiality is of paramount importance. This study aims to examine the impact of social media marketing (SMM) dimensions on customer knowledge management (CKM) in UAE public banks, focusing on the moderating role of banking confidentiality. The study utilized a quantitative methodology with a correlational framework; data were collected from 283 respondents, who are active customers of First Abu Dhabi Bank, Emirates NBD, and Abu Dhabi Commercial Bank, through a structured questionnaire. These customers were surveyed to understand their interaction with social media campaigns, the information banks request from them, their willingness to share personal data, and their perceptions of safety and legal protections. The results revealed a strong positive relationship between SMM dimensions and CKM, with SMM explaining 65.9% of the variance in CKM outcomes (R² = 0.659, p < 0.01). Among the SMM dimensions, customization had the highest impact (R² = 0.766), followed by word-of-mouth (R² = 0.697) and aesthetics (R² = 0.651). Additionally, confidentiality was found to significantly enhance the effectiveness of SMM, with a moderating effect increasing explained variance by 6.5% (ΔR² = 0.065, β = 0.25, p < 0.01). These findings suggest that public banks in the UAE should integrate personalized SMM strategies with stringent confidentiality measures to optimize CKM. This approach not only enhances customer engagement but also builds trust, fostering sustainable growth in the digital era.
Acknowledgements The authors are thankful to the Deanship of Graduate Studies and Scientific Research at University of Bisha for supporting this work through the Fast-Track Research Support Program.
How do environmental awareness, IT use, and credit access shape the sustainability of Indonesian MSMES?
Authors: Ismanto Hadi , Nahar Aida , Pebruary Silviana , Adi Wibowo Purwo , Nuril Firdaus Miftakhussabili
Published: December 2024

This study aims to analyze the influence of environmental awareness, information technology (IT) use, and access to credit as moderators on the sustainability of Indonesia’s micro, small, and medium enterprises (MSMEs). Data were obtained through a survey of 1,374 MSMEs. Sampling was carried out using purposive sampling techniques, targeting MSMEs that had been established for more than 3 years and had received loans from financial institutions. The analysis used the ordinary least square (OLS) regression method to evaluate the relationship between the independent variables and MSME sustainability. The results show that environmental awareness and IT use significantly positively affect MSME sustainability. Credit access was also found to have a significant and positive effect. However, the interaction between credit access, environmental awareness, and IT use resulted in a small but significantly negative effect. This suggests that an excessive increase in credit access might reduce the positive impact of environmental awareness and IT use on MSME sustainability. Overall, this study confirms the importance of environmental awareness and information technology in improving MSME sustainability and highlights the need for proper management of credit access.
AcknowledgmentAppreciation is given to the Directorate General of Higher Education, Research and Technology, Ministry of Education, Culture, Research and Technology, which has provided a fundamental research grant with contract number 108/E5/PG.02.00.PL/2024. Acknowledgments are also expressed to higher education service institutions (LLDIKTI) Region 6 and the Institute of Research and Community Services (LPPM) Unisnu Jepara Indonesia, which has supported this research.
Gelecekten Haber Veren Oğuz Bilgesi: Dede Korkut
Authors: Demirtaş Sezai
Published: December 2024

Bilinmezlikler içermesi nedeniyle insanda merak hissi uyandıran gelecek, tarihin her döneminde anlaşılmaya gayret edilen bir zaman dilimidir. Zihninde geleceğin kendisine neler getireceğini bilme isteği yatan insan, söz konusu merakın bir sonucu olarak gelecekten haber almak ve bilinmeyeni anlamak için birtakım arayışlara girmiştir. İşte bu noktada kâhin, şaman/kam, falcı, veli vb. kişiler tarafından kehanet ve keramet gibi başlıklar altında geleceğe dair bilgi verme eylemi ve yeteneği değer kazanmıştır. Gelecekten haber verme adıyla bilinen bu yeteneğe sahip kişiler arasında Oğuz bilgesi Dede Korkut/Korkut Ata da bulunmaktadır. Tarihî ve edebî eserlerde yer alan bilgilerden yola çıkılmak suretiyle, Dede Korkut’un gelecekten haber verme yeteneğinin Türkistan/Türkmen Sahra nüshasında bulunan on sekizinci soylama bağlamında tartışıldığı bu çalışmada, Dede Korkut’un toplum hayatı ve tabiat koşullarıyla ilgili öngörüleri hakkında değerlendirmeler yapılmıştır. Gaipten haber verdiği ifade edilen Dede Korkut’un söz konusu yeteneğini ortaya koyan birkaç öngörüsü dışında herhangi bir kehanetiyle karşılaşılmaması, Dede Korkut araştırmalarında bu yönünün zayıf kalmasına neden olmuştur. Türkistan/Türkmen Sahra nüshasında yer alan soylamayla birlikte farklı bir boyut kazanan bu durum, Dede Korkut’un geri planda kalmış bir özelliğinin öne çıkarılmasına imkân tanıdığı gibi gaipten haber verebilme yeteneğini de ortaya koymaktadır.
Innovative physical techniques in freeze-drying
Authors: Andreeva Oksana , Shorstkii Ivan
Published: December 2024

Malnutrition is a global problem that is caused by insufficient sources of vitamins, microelements, and other nutrients. This creates a need for developing long-term preservation techniques. One of the solutions is to pre-treat food materials before freeze-drying by applying advanced and safe electrophysical techniques instead of traditional thermomechanical methods.
We reviewed three of the most promising electrophysical techniques (low-temperature plasma, ultrasound, and pulsed electric field) which have proven effective for a wide range of food materials. In particular, we focused on their mechanism of action and the equipment required, drawing on successful laboratory and large-scale studies in Russia and abroad.
The electrophysical techniques under review had an etching effect on the material, caused electroporation, and changed the material’s internal structure. In addition to these effects, we described their process and technology, as well as their advantages and disadvantages in industrial applications.
Based on literature analysis, we stressed the importance of developing innovative electrophysical techniques for the food industry. These techniques should ensure high energy efficiency of the freeze-drying process and maintain good quality characteristics of food products.
Strategic Principles for Improving Corporate Management in Mining and Metallurgy
Authors: Taparov Kurbanmurat
Published: December 2024

Navoi Mining and Smelting Works, Uzbekistan, is one of the four largest gold miners in the world. Over its 65 years of history, the company has developed from an industrial pioneer to a full cycle of gold production. These days, it performs innovative exploration as well as produces finest products of the highest quality. On January 1, 2022, the company initiated an intensive large-scale transformation to shift to the principles of modern corporate management. This article examines the initial results of implementing new strategic principles at Navoi Mining and Smelting Works. The author defined the phenomenon of corporate management and its effect on business growth and development, followed by a case study of corporate management at Navoi Mining and Smelting Works. Its strategic principles and results were compared with those reported by Top 10 mining companies in the world.
Modelling of shallow groundwater levels and interaction with drainage system and streams under the impact of climate change
Authors: Thorndahl Søren , Nielsen Rasmus Vest
Published: December 2024

Under the impact of climate change, groundwater levels are anticipated to increase in temperate climatological zones with increased precipitation and sea level rise. Urban areas located at low elevations are especially at risk, and increased shallow groundwater levels can lead to flooding, water seepage into basements, capacity problems in water infrastructure, etc. Furthermore, old sewer systems can act as drains by allowing groundwater to seep into the sewer system. This process can artificially maintain the groundwater level low, and therefore if the sewer system is rehabilitated, the problems are even increased further if necessary solutions are not included in the planning process. In this article, we analyze an urban catchment in Aalborg, Denmark, which is currently facing problems with high groundwater levels. By simulating the groundwater interaction with sewer systems and watercourses, we show that the groundwater table can increase up to 1 m under the impact of sewer rehabilitation and climate change. This increase will lead to significant flood risk in the residential area. We propose multiple technical solution scenarios and evaluate their effectiveness, demonstrating how the impact of increasing groundwater levels can be mitigated through implementation of drains during sewer reconstruction, but not completely avoided.
Using digitalisation for a real-word implementation of an early warning system for water leakages
Authors: Oberascher Martin , Maussner Claudia , Hinteregger Petra , Knapp Jürgen , Halm Andreas , Kaiser Mario , Gruber Wolfgang , Truppe Dietmar , Eggeling Eva , Sitzenfrei Robert
Published: December 2024

A timely detection and localisation of leakages is of highest interest to reduce water losses. As stated in the literature, most leakage detection and localisation methods consider unrealistic assumptions and are rarely assessed under real-world conditions. To overcome these limitations, an early warning system for new leakages is implemented in a real-world case study. Therefore, the case study is equipped with digital water meters at customer sites to monitor household water demands at 15-min resolution. These data are subject to the European General Data Protection Regulation, which requires the active customers consent (and therefore some refusals), and are also subject to data loss during transmission due to the use of wireless data communication. The incomplete data (costumer refusals and transmission failures) were then used for the early warning system, including data-based detection and model-based localisation, and tested on 10 engineered leakage events. Thereby, small leakages up to a size of 0.4 l/s could be detected reliably even under high demand fluctuations. Additionally, the search area for the fine search on site could be reduced to 10–40% of the entire district metered area for leakage sizes between 0.1 and 2.0 l/s also under these real-world boundary conditions.
Groundwater remediation action plan of polluted aquifer by heavy fuel oil, Northern Jordan
Authors: El-Naqa Ali Ramadan
Published: December 2024

This study investigates the sources and pathways of groundwater contamination by heavy fuel oil (HFO) at the Al Hussein Thermal Power Station (HTPS) in northern Jordan using hydrogeological and geophysical methods. Initial surveys identified Wells #8 and #9 as primary contamination points, revealing that the contamination originated from a leaking oily water drain beneath the boilers at HTPS. The contamination plume was confined to an area of approximately 0.5 km2 at a depth of around 50 m, confirmed by additional boreholes near the plant boundaries. To remediate the polluted groundwater, the Central Electricity Generating Company (CEGCO) applied a pump-and-treat approach, extracting about 16,200 m3 of contaminated water over 3 months at a rate of 90 m3/h, twice daily. This process reduced total petroleum hydrocarbon levels from initial concentrations of over 10 mg/L to below detectable limits (<0.5 mg/L). The pH-REdox-EQuilibrium modeling revealed that biodegradation of HFO led to increased levels of total dissolved solids from 1,400 mg/L to over 2,600 mg/L and elevated sulfate concentrations, impacting the aquifer's overall water quality. The remediation plan not only addressed immediate contamination but also focused on preventing further leaks and restoring groundwater quality in the long term.
A Comprehensive Review of Nanostructured Lipid Carriers: Innovations
and Applications in Breast Cancer Treatment
Authors: Mirajkar Prathamesh , Ahlawat Priyanka , Patel Asha , Patel Shruti , Panjwani Drishti
Published: December 2024

Nanostructured Lipid Carriers (NLCs) represent a promising advancement in the treatment
of breast cancer, addressing the significant challenges posed by conventional chemotherapy,
such as poor drug solubility, short half-lives, and high toxicity. This review delves into the potential
of NLCs to overcome these limitations, highlighting their unique structure comprising a solid and
lipid liquid core stabilized by surfactants. By examining diverse lipid blends used in the preparation
of NLCs, the article emphasizes their suitability for targeted drug delivery. Various facets of NLC
configuration, categorization, composition, and formulation approaches are systematically explored
to provide a comprehensive understanding of their attributes. The findings reveal that NLCs possess
a high capacity for lipophilic drugs and offer advantages over traditional lipid-based nanocarriers.
The review underscores the pivotal role of NLCs in enhancing drug delivery efficiency for breast
cancer therapy while minimizing systemic toxicity. Conclusively, this review positions NLCs as a
key player in the evolution of drug delivery systems for breast cancer treatment, providing a detailed
outlook on their transformative potential and contributing to a nuanced understanding of their
significance in advancing the field of breast cancer treatment.
A intercompreensão românica e a pluricentricidade linguística no ensino do PLE: desmistificando a doxa uma língua, uma norma, uma cultura
Authors: Manole Veronica
Published: December 2024

In this paper we advocate the introduction of Romance
intercomprehension and the pluricentric approach in classes of Portuguese as a
Foreign Language (PFL), to speed up the learning process and raise students’
awareness regarding the Lusophone cultures and the linguistic variation. After short
theoretical presentations on Romance IC and the pluricentrism of the Portuguese
language, we address twelve myths surrounding these approaches. Then we suggest
a few IC and PFL textbooks that could help teachers and give a brief presentation of
the Portal do Professor de Português Língua Estrangeira/Língua Não-Materna (PPLE) as
an excellent resource for teaching PLE from a pluricentric perspective
Adding ZnO to Cellulose/ZnO Nanocomposites Coated A36 Steel Increases The Corrosion Rate
Authors: Barasa Alvadro , Wahjudi Ari , Pratama Rizki Ramadhani , Kriswardhana Willy
Published: December 2024

Corrosion caused by electrochemical reactions is common in everyday life. Consequently, the phenomenon occurs due to the tendency of elements to return to stable compounds. A coating process can provide an effective corrosion control method can be achieved by conducting a coating process. The coating process can be carried out using nanocomposites of two or more substances. The addition of these substances is expected to cover each other's shortcomings. In this research, the material used is A36 steel coated with nanocomposites in the form of HEC as a cellulose matrix and ZnO as a filler. Also, the corrosion rate was tested using an electrochemical method with a 1M HCl solution and a ZnO nanocomposite composition that ranged from 5 to 15%. The results showed that the 10% HEC/ZnO variation had the smallest corrosion rate with an efficiency of 88.9%. In addition, this research indicates that HEC/ZnO nanocomposite is a suitable alternative coating for A36 steel.
Термины «археологический источник», «неолит» и «неолитизация» в контексте изучения неолита как археологической эпохи и их место в археологической научной лексике
Authors:   B. B. Gorodovikov Kalmyk State University (11, Pushkin St., 358000 Elista, Russian Federation), Koltsov Petr M. , Grebenyukov Vladimir I. ,   Nizhnevartovsk State University (56, Lenin St., 628624 Nizhnevartovsk, Russian Federation)
Published: December 2024

The paper presents the results of a comparison of the osteometric characteristics of the Eneolithic and Early Bronze Age (EBA) series by comparing descriptive statistical data and using the non-parametric Mann-Whitney test. On the one hand, there is a significant difference between the relatively mesomorphic Khvalynsk Eneolithic population and the extremely massive skeletons from the Yamna culture of the Volga region. On the other hand, the EBA group has similarities with the Neolithic-Eneolithic series from the Dnieper-Don region. This result provides additional support for the hypothesis that the Yamnaya culture population originated in the Dnieper-Don area. The descendants of Mariupol Neolithic population or groups occupying the western fringe of the Khvalynsk-Sredny Stog Eneolithic cultural region likely served as the substrate for the development of the Yamnya population. The paper also examines environmental factors that influence the variability of the postcranial skeleton. Increased aridization in the climate during the early Bronze Age is assumed to have led to a reorientation of economic activities towards mobile cattle breeding. This, in turn, is expected to result in increased physical activity among the population and the introduction of a new protein source in the diet through dairy products. These changes could explain the increased hypermorphism of the skeletal remains of people from the Yamnaya culture.
СИЛОВЫЕ И СВЧ-ТРАНЗИСТОРЫ НА ОСНОВЕ НИТРИДА ГАЛЛИЯ ОТ АО «НИИЭТ»: ДОСТУПНЫЕ РЕШЕНИЯ И ПЕРСПЕКТИВЫ
Authors: Семейкин И.
Published: December 2024

В Стратегии развития электронной промышленности Российской
Федерации на период до 2030 года нитрид-галлиевая (GaN) технология
внесена в ключевое направление «Научно-техническое развитие».
Эта технология – одна из наиболее перспективных в области создания
силовой и СВЧ ЭКБ, и ее развитие в стране крайне важно со стратегической
точки зрения.
В статье приводятся преимущества GaN-технологии для силовой
и СВЧ-электроники, некоторые сведения об истории ее развития, текущем
состоянии и перспективах, данные о возможностях и планах АО «НИИЭТ»
(входит в Группу компаний «Элемент») по производству GaN-компонентов
и характеристики ряда силовых и СВЧ-транзисторов разработки
и производства предприятия.
The content of Ayatollah Sistani’s charismatic authority: the affective bond
Authors: Alsayegh Ali
Published: December 2024

Historically, Ayatollah Sistani’s calls to action have mobilised hundreds of thousands and even millions of his followers into different forms of political mobilisation in the post-2003 Iraqi context (e.g. voting, demonstrations, and armed jihad). A fundamental reason for this is his charismatic authority. Pre-existing literature on Sistani’s charisma has salient shortcomings in providing a conceptually coherent framework to capture how the Ayatollah inspires Weberian ‘absolute trust’ in his religio-political leadership. The present research seeks to compensate for this by offering an alternative approach to understanding Sistani’s charisma, which is informed by 40 semi-structured interviews conducted in 2022 with his followers and other seminary and academic personalities in Iraq. The content of his charismatic authority is referred to as the ‘affective bond’, which is a cognitive-emotional connection between the followers and Sistani premised on the former’s recognition of him as a symbol of legitimacy, hope, and authenticity. These perceptions confirm the ‘absolute trust’ that followers have in Sistani, which becomes the cognitive basis of their emotional willingness to answer his calls to action. In undertaking the mission of this paper, the intimate interplay between narratives, history, culture, rituals, practices, history, storytelling, and the perceptions that produce Sistani’s charismatic authority, will come to light.
American Studies in Sweden: Navigating an Archipelagic Field
Authors: Bonnevier Jenny , Hjorthén Adam , Mays Christin
Published: December 2024

This essay sets out to map the teaching of American studies in Sweden. Since American studies is not a degree-awarding disci-pline in Sweden, this is not a straightforward task. The first part of the essay discusses American studies as it looks at the only center of higher educa-tion in Sweden that identifies it as a subject, the Swedish Insti-tute for North American Studies at Uppsala University. In the second part we look at the field in a broader sense, identifying courses about North America currently available at Swedish universities, and surveying their subjects and topics. Together, the two parts outline the con-tours of a field of teaching that, we suggest, is best described as archipelagic. The essay con-cludes with a discussion of the possibilities and challenges for American studies teaching in Sweden and offers some thoughts and suggestions for the future, arguing for increased teacher and institutional coop-eration, and the need to estab-lish American studies as a de-gree-awarding discipline.
Nikolai Klyuev and Sergei Yesenin: Dialogue with the Epoch
Authors:   A.M. Gorky Institute of World Literature of the Russian Academy of Sciences, Seregina Svetlana A.
Published: December 2024

The monograph is the first generalizing work devoted to the creative dialogue between Yesenin and Klyuev in the literary and philosophical context of the epoch. The book examines the main stages of this dialogue, as well as the evolution of artistic and ideological dominants in the creative consciousness of both poets. The work of Klyuev and Yesenin is analyzed in the light of the formation and development of the main ideals that united the poets: religious, social and creative. The identification and analysis of the sources of these ideals entails referring to the works of A.S. Pushkin, M.Y. Lermontov, A.V. Koltsov, A.A. Blok, Andrei Bely, A.M. Dobrolyubov, V.I. Ivanov, R.V. Ivanov-Razumnik, L.D. Semenov, L.N. Tolstoy, V.S. Solovyov, F.-R. de Lamennais and others. The book is intended for philologists, historians and specialists in cultural studies, teachers and students, and anyone interested in the work of Yesenin and Klyuev, the history of Russian literature and culture.
Challenges and opportunities for the use of digital information and communication technologies in education during the COVID-19 pandemic: an experience with active methodologies
Authors: Moreira Franciely Pereira , Ferreira Samara Ahyeska Alves , Lima Danielli Araujo
Published: December 2024

The use of digital communication and information technologies allows the creation of more dynamic and interactive classes, which favor collaboration between students and the personalization of teaching, facilitating the adoption of hybrid teachingmodels that combine the best of the face-to-face and online worlds. Thus, this experience report discusses how the COVID-19 pandemic has transformed education, increasing the need to use technologies in the classroom and allowing distance learning. It highlights the importance of investments in equipment and data packages to ensure that all students are included in the teaching-learning process. In this same context, the use of gamification tools, such as Flippity and Wordwall, can make the learning process more dynamic and attractive. The objective of the article is to present opportunities and threats regarding the use of these tools, as well as active blended learning methodologies, and propose an action plan to support teachers to develop digital skills and work with personalization and group learning in a more integrated way. and collaborative.
Um survey sobre fatores que influenciam a permanência e o ingresso de estudantes em cursos de sistemas de informação
Authors: Valle Pedro Henrique , Melo Silvana M. , Prates Jorge Marques
Published: December 2024

A procura por cursos de graduação em computação, principalmente em Sistemas de Informação (SI), vem aumentando nas universidades. Apesar disso, a taxa de evasão neste curso continua muito alta. Para isso, conduzimos um survey com 55 alunos dos cursos de Sistemas de Informação de três universidades brasileiras para identificar os principais fatores que impactam o ingresso e a permanência dos alunos nesses cursos. Os resultados indicam que as ações, como a oferta de bolsas e infraestrutura e a qualidade do corpo docente e das aulas ministradas, são aspectos centrais que contribuem para a permanência dos alunos. Como principal contribuição, essas evidencias podem servir de base para propor estratégias para reduzir a evasão.
SCIENCE: Um software baseado em ontologia para apoiar a utilizac¸ ˜ao de Rob´otica Educacional
Authors: Fernandes Silvio Roberto , Passos Daniel Deyson Nunes , Silveira Vinicius Sales da , Queiroz Paulo Gabriel Gadelha
Published: December 2024

O ensino-aprendizado de conte´udos de Matem´atica no Ensino Fundamental II apresenta alguns desafios que podem ser superados com a utilizac¸˜ao de tecnologias, entre as quais destaca-se a Rob´otica Educacional (RE), que vem ganhando espac¸o em ambientes escolares. Entretanto, observou-se que sua utilizac¸˜ao cresce de forma lenta, quando comparado ao seu potencial de impacto no ensino. Isso acontece, principalmente, devido a escassez de materiais e ferramentas que auxiliem os professores em sala de aula. Para ajudar a suplantar essa dificuldade, este trabalho apresenta um software baseado em ontologia, para gerar planos de aula da disciplina de matem´atica utilizando RE. O software SCIENCE foi constru´ıdo a partir de requisitos coletados por meio de entrevistas realizadas com professores de matem´atica do ensino fundamental II. O resultado das entrevistas somado aos manuais de montagem dos kits de rob´otica LEGO e aos conte´udos da BNCC, guiaram o desenvolvimento de uma ontologia, que serviu de base para a construc¸˜ao do software. Por fim, o SCIENCE foi avaliado por 31 professores das disciplinas de ciˆencias exatas, por meio de question´arios elaborados com base na metodologia TAM. Os resultados da avaliac¸˜ao indicaram a aprovac¸˜ao do software pelos professores como ferramenta pedag´ogica, al´em de direcionamentos para melhor´a-lo.
Anais [do] 9. Encontro de Terapia Ocupacional: práticas integradas em diálogo com a Fisioterapia
Published: December 2024

O 9º Encontro de Terapia Ocupacional: práticas integradas em diálogo com a Fisioterapia, foi espaço de diálogo e troca de experiências entre profissionais, estudantes e pesquisadores da área da saúde. O evento buscou promover o fortalecimento das práticas integradas entre terapia ocupacional e fisioterapia, com o objetivo de fomentar novas abordagens terapêuticas e inovadoras. Incentivamos que estudantes e profissionais compartilhassem suas ações em formato de resumos e apresentações nesse evento, destacando as sinergias e colaborações que contribuem para o cuidado integral e centrado no paciente.
Heaven on Earth: Revelation of the 10th Avatar
Authors: Bradly Couch
Published: December 2024

"Heaven on Earth: Revelation of the 10th Avatar" makes connections between ancient myths and Earth's topography that correspond to Hinduism's ten incarnations of Vishnu, resulting in visual evidence of the prophesied return of Kalki to usher in the Golden Age of Satya Yuga.
O NÍVEL DE ALAVANCAGEM COMO CONDICIONANTE DO PROCESSO DE CAPTURA REGULATÓRIA EM SETORES DE UTILIDADE PÚBLICA
Authors: Rufino Maria Audenora , Cavalvante Paulo Roberto Nobrega
Published: December 2024

O objetivo consiste em investigar se o nível de alavancagem condiciona o processo de captura regulatório, em setores de utilidade pública no Brasil. O captura regulatória ocorre quando os agentes regulados influenciam o órgão regulador para obterem vantagens em suas decisões. Nesse contexto, alguns aspectos da empresa, como o grau de alavancagem, podem ser utilizados como instrumentos de pressão sobre o regulador, visando favorecer seus interesses particulares. A amostra foi composta por empresas reguladas por preço, pertencentes aos setores de saneamento, gás natural canalizado e energia elétrica, operando no Brasil, de 2007 a 2019. As variáveis utilizadas foram: retorno anormal (dependente), mudança tarifária, alavancagem (independentes) e propriedade, crescimento econômico, tamanho e setor. Os resultados sugerem que o nível de alavancagem, usado de forma estratégica pelo regulado, pode possibilitar decisões regulatórias mais favoráveis aos interesses das empresas. Observou-se que a captura não é generalizada, porque a mudança tarifária não explica o retorno anormal de forma isolada, mas indica como a alavancagem pode conduzir a captura do processo regulatório, por meio da mudança tarifária.
Potentially toxic elements from different environmental compartments of the River Watershed in Eastern Serbia: Assessment of the human health risk
Authors: Mihajlidi-Zelic Aleksandra , Sakan Sanja , Ignjatovic Ljubisa , Popovic Aleksandar , Djordjevic Dragana
Published: December 2024

This study assessed human health risks due to exposure to potentially toxic elements (PTES) in soil and river water in eastern Serbia. Concentrations of As, Cu, Cd, Zn, Pb, Ni and Cr were measured in soil and river water from the Vlasina watershed area. The concentrations of Cl-, SO4 2- and NO3 - were also measured in the river water. According to the Regulation of the Republic of Serbia, the water quality of the investigated rivers corresponds to the surface water quality Class I and II. The content of PTEs in soil was below soil guideline values. Children were more sensitive than adults when exposed to PTE in water and soil. Arsenic was the dominant contributor to the total non-carcinogenic and carcinogenic risks for exposure to PTE in water. For PTE in soil, As had the dominant contribution to non-carcinogenic risks, and Ni to carcinogenic risks. All hazard index (HI) values for adults and children are less than 1, which indicates that the impact of PTEs in the examined river water and soil on human health is insignificant. Ingestion route is a major contributor to both total non- -carcinogenic and carcinogenic risks.
The Influence of Cross-Border Cooperation between Securities Regulators on Audit Fees
Authors: Kong Xiangting , Tsang Albert , Wang Yujie , Xiang Yi
Published: December 2024

In this study, we examine the influence of the Multilateral Memorandum of Understanding Concerning Consultation and Cooperation and the Exchange of Information (MMoU), a special cooperative arrangement designed to enhance cross-border regulatory enforcement, on the audit fees imposed on U.S.-listed foreign firms. Using the different times of countries’ entry into the MMoU as a staggered shock, we find that after a foreign country enters the MMoU, the audit fees for its U.S.-listed firms increase to a greater extent than those for either foreign firms or U.S. domestic firms. This effect is stronger for U.S.-listed foreign firms from countries with weaker institutions and for auditors with a higher level of firm-specific litigation concern, as measured by firms’ auditing by Big 4 auditors.