bluuebunny/crossref_metadata_2025 huggingface dataset:
Vertical Integration Practice: The Case of PT Solusi Transportasi Indonesia and PT Teknologi Pengangkutan Indonesia
Authors:   Faculty of Law, Universitas Indonesia Jl. Prof. Mr Djokosoetono, Pondok Cina, Kecamatan Beji, Kota Depok, Jawa Barat 16424, Rifdah Azizah Saffanatullah , Siahaan Clarissa Zion Putri ,   Faculty of Law, Universitas Indonesia Jl. Prof. Mr Djokosoetono, Pondok Cina, Kecamatan Beji, Kota Depok, Jawa Barat 16424, Sinaga Elsa Ruth Paranita ,   Faculty of Law, Universitas Indonesia Jl. Prof. Mr Djokosoetono, Pondok Cina, Kecamatan Beji, Kota Depok, Jawa Barat 16424, Simanjuntak Yohanna Amelia ,   Faculty of Law, Universitas Indonesia, Jl. Prof. Mr Djokosoetono, Pondok Cina, Kecamatan Beji, Kota Depok, Jawa Barat 16424
Published: October 2022

Business actors often use vertical integration agreements as an instrument to take control of several business activities including the production process of certain goods and/or services and avoid uncertainty over the supply of raw materials to produce goods and/or services. By using vertical integration, a company will get benefits which are the efficiency of production costs so that the profits obtained by a company are greater. One of the examples of vertical integration agreement practice is the case of an affiliation between PT. Solusi Transportasi Indonesia (Grab Indonesia) and PT Teknologi Pengangkutan Indonesia (PT TPI). The agreement between Grab Indonesia and PT TPI give rise to allegations of violation of vertical integration of the agreement build by both parties, namely the element of production control in the form of discrimination against business actors competing with PT TPI which subsequently had a further impact on drivers who are not partners of PT TPI. This paper uses a normative juridical research method with a statutory approach, a case approach, and a conceptual approach. This paper discusses cases based on vertical integration theory and its development, then assesses the vertical integration agreement between Grab Indonesia and PT TPI.
The Future of Online Dispute Resolution: Building A Framework for E-Commerce Dispute Resolution in Indonesia
Authors:   Department of Law, Social and Political Science, Universitas Terbuka, Jl. Pd. Cabe Raya, Pd. Cabe Udik, Kec. Pamulang, Kota Tangerang Selatan, Banten 15418, Indonesia, Rizkiana Rina Elsa
Published: October 2022

There was a legal issue, the gap between e-commerce dispute resolution (das sollen) in the Act and its implementation in the field (das sein). E-commerce disputes required a resolution, such as Online Dispute Resolution (ODR). ODR hasn't conducted a face-to-face method, low cost, and covers wide areas. However, ODR wasn't regulated in a "lex specialis" for its implementation. This study discussed several business settlement problems through ODR. Besides, the implementation of the prospect of ODR as a new form of construction of e-commerce transaction dispute resolution in Indonesia. This study provided an understanding of ODR and how the law used to mediate community disputes by using the internet as an alternative possibility to resolve conflicts in society in Indonesia. This paper described the probabilities and challenges of implementing ODR. This paper was normative juridical research which was collected through literature study. The research analysis used a statute approach and a comparative approach. The results showed the mechanism of ODR solved the e-commerce dispute. ODR's execution was in line with the trade sector development. ODR regulated for provided and supported the consumer protection law in Indonesia. ODR regulations in Indonesia should be regulate explicitly to provide legal certainty for the community.
Cryptocurrency–The Internet "Dollar": Comparative Analysis of Regulations on Cryptocurrency Between Indonesia, Singapore, and China
Authors:   International Business Law Program, Universitas Prasetiya Mulya, BSD City Kavling, Jl. Edutown Jl. BSD Raya Utama No.1, BSD City, Kec. Pagedangan, Tangerang, Banten 15339, Indonesia, Lorenscia Hellen
Published: October 2022

Nowadays, the development of digital money and the numerous benefits it provides has had a significant impact on many parts of life. However, it is undeniable that these advances carry a number of concerns as well. As a result, each country has a different perspective on regulating this digital money, particularly in terms of its benefits as a payment mechanism. The purpose of this study is to compare the regulation and legality of using digital money as a payment mechanism in Indonesia, Singapore, and China by employing the normative legal research. Digital money is not allowed to be utilized as a payment mechanism in Indonesia. On the other hand, digital money is regarded as an intangible asset that can be used as a payment method in Singapore. China, on the other hand, has outlawed the usage of digital money for both investment and payment. Each country has its own considerations, and there are various things that Indonesia may learn from Singapore and China's arrangements in order to maximize the benefits of digital money.
Spigelian Hernia and Appendicitis: A Rare Case Report
Authors: Eydou Zehdi , Issa Hamza Wajeeh , Kamalakannan Theekshitha , George Biji Thomas , Maasher Ahmed
Published: October 2022

Introduction:

Hernias containing the appendix are well-known entities that preferentially affect the groin. The presence of an appendix within a Spigelian hernia, which is a rare ventral hernia that presents with nonspecific symptoms and location, adds significantly to the complexity and rarity of its diagnosis. Further, only 18 such cases were reported and published in the literature. We report a case of Spigelian hernia and appendicitis within the hernial sac to highlight the diagnostic challenges associated with this type of hernia.

Case Presentation:

In her late 30s, a female who underwent laparoscopic surgery for a uterine fibroid two and a half years back presented with right lower quadrant abdominal pain for two days. This followed abdominal pain on exertion for the previous nine months. On examination, there was tenderness, guarding, and a positive cough impulse in the right lower quadrant of the abdomen. Her body mass index was 37.53 kg/m2. A contrast-enhanced computed tomography imaging of the abdomen reported a right iliac fossa incisional hernia with omental congestion necessitating an emergency laparoscopic surgery. At surgery, a Spigelian hernia, which was at least 5 cm away from the port site scar of the previous surgery, was found. The hernia contained an inflamed appendix. Thus, a diagnosis of Spigelian hernia and appendicitis within the hernial sac was made. A laparoscopic reduction and repair of the Spigelian hernia and a laparoscopic appendectomy were performed.

Conclusion:

Whereas Spigelian hernias are considerably rare, the presence of an appendix within a Spigelian hernia sac is yet a more infrequent occurrence. Although the imaging modalities are often inconclusive, careful interpretation of the computed tomography imaging findings may reveal the pathology preoperatively.
Exploring the Targets of Novel Corona Virus and Docking-based Screening
of Potential Natural Inhibitors to Combat COVID-19
Authors: Dey Rishita , Samadder Asmita , Nandi Sisir
Published: October 2022

There is a need to explore natural compounds against COVID-19 due to their multi-targeted actions against various targets of nCoV. They act on multiple sites rather than single targets against several diseases. Thus, there is a possibility that natural resources can be repurposed to combat COVID-19. However, the biochemical mechanisms of these inhibitors were not known. To reveal the mode of anti-nCoV action, structure-based docking plays a major role. The present study is an attempt to explore various potential targets of SARS-CoV-2 and the structure-based screening of various potential natural inhibitors to combat the novel coronavirus.
Applications of Polymethylhydrosiloxane (PMHS) in Organic Synthesis-
Covering up to March 2022
Authors: Alam Mohammed Mujahid , Seema Vittal , Dubasi Narsimhaswamy , Kurra Mohan , Varala Ravi
Published: October 2022

Based on the type of metal or non-metal catalyst used, the authors of this paper have clearly
highlighted the different applications of air-stable, commercially viable, and environmentally friendly
polymethylhydrosiloxane (PMHS) in organic synthesis or other allied reactions. The importance of
PMHS was emphasised for the particular organic transformation's success. In addition to its wellknown
use as a reducing agent, it has also been demonstrated in a variety of other applications, including
ring cleavage, the cotton industry, functional material for microfluidic chips, and the dehydroaromatization
of bio-oils. The article tries to compile the most noteworthy cases of highly successful
PMHS catalysis over the past two decades or so.
Extraction and Analysis of Microplastic Beads from Personal Care Products
Authors: Gore Anil H. , Bhavsar Pinal S.
Published: October 2022

Background:

Nowadays, plastic accumulation in marine has become one of the topics of global
concern, with emerging research efforts focusing on the threat of microbeads (<5mm). A source of microplastic
pollution is derived from personal care products (facial cleanser) that contain polyethylene
microplastic (microbeads), which are not captured by the wastewater treatment plant. These small particles
are especially concerning because of their potential to translocate in the bodies of organisms.

Methods:

Herein, we have used a mixture of hydrogen peroxide with nitric acid to dissolve the organic
matter before the filtration and filtration was carried out by using Whatman filter paper 42 to ascertain
that all the microbeads had been collected. Collected microbeads were identified using Fouriertransformed
infrared spectroscopy (FT-IR) and stereo microscope.

Results:

In this study, we have observed that personal care products contain microplastic beads, and that
three out of six personal care products contain a polyethylene (PE) bead.

Conclusions:

We have provided a feasible separation and analysis method for microplastic beads in personal
care products.
Evaluation of the Factors Associated with Prescribed and Non-Prescribed
Medicine: A Population-Based Study
Authors: Eskandari Mehrnoosh , Alizadeh Bahmani Amir Hossein , Hoorang Mehdi , Zare Marziyeh , Afifi Saba , Karimzadeh Iman , Azadi Soha , Sabzghabaee Ali Mohammad , Lankarani Kamran B. , Ahmadizar Fariba , Peymani Payam
Published: October 2022

Objectives:

Several factors influence medication patterns. The purpose of this study was
to look into the role of social determinants in the use of prescribed and non-prescribed medications
in a population-based setting of people over 18 in a southern metropolis of Iran (Shiraz) for 2
years.

Study Design:

Prospective population-based cross-sectional.

Methods:

This descriptive and cross-sectional survey was done in 2018-2020. A total of 1016 participants
were randomly selected based on their postal codes and recruited to the study. The demographic
characteristics (age, sex, and education), social profiles (insurance, supplementary insurance,
health status, and daily exercise plan), and outpatient visits (family/general physician or specialist/
subspecialist) were recorded by gathering sheets. Descriptive analyses and multinomial logistic
analyses were carried out using SPSS software.

Results:

The medication use pattern was classified into three categories: non-prescribed type I,
non-prescribed type II, and prescribed. The mean age of participants was 45.54 ± 15.82 years. The
results indicated that most of them took their medication without a prescription (non-prescribed
type II). However, people who had insurance and referred to a family physician commonly used
the prescribed medications. This study also found that patients who visited a family doctor or a
general practitioner used fewer prescribed drugs than those who visited a specialist.

Conclusion:

This study describes social determinants as additional effective factors in health services
that influence the use of prescribed and non-prescribed medications in Shiraz. These evidence-
based findings can help policymakers to plan the best programs.
Advances in the Study of Hexokinase 2 (HK2) Inhibitors
Authors: Tong Yan , Li Xiaofei , Dong Chunhong , Wang Shaopei , Zhuang Yan , Xu Jindan
Published: October 2022

Purpose:

The Warburg effect is an important metabolic feature of tumours, and hexokinase is the first rate-limiting enzyme of the glycolytic pathway during tumour metabolism. Among hexokinase subtypes, hexokinase 2 (HK2) is increasingly proving to be a key target for cancer treatment. This study presents the challenges and potential strategies for developing HK2 inhibitors by systematically summarising the characteristics of HK2 inhibitors reported in the literature and patents.

Methods:

In this study, we analysed the HK2 active site using molecular docking and evaluated the structure, biochemical and physiological function, activity, and action mechanism of reported HK2 inhibitors using databases (Science, SCI finder, CNKI, and WANFANG DATA).

Results:

In total, 6 natural inhibitors of HK2, 9 synthetic inhibitors of HK2, and 3 compounds with patent-pending HK2 inhibitory effects were obtained by searching 87 articles. These inhibitors have poor efficacy and specificity when used alone and have numerous side effects; therefore, there is an urgent need to develop HK2 inhibitors with improved activity and high selectivity.

Conclusion:

HK2 has received much attention in anticancer drug development, but most previous studies have focused on elucidating the action mechanism of HK2 in carcinogenesis, whereas the development of its small-molecule inhibitors has rarely been reported. In this study, we analysed and illustrated the eutectic structure of small molecules with the catalytic structural domain of HK2 to develop highly selective and low-toxicity HK2 inhibitors.
Correlation between Diabetes Mellitus and Peri-implantitis: A Systematic
Review
Authors: Dioguardi Mario , Cantore Stefania , Quarta Cristian , Sovereto Diego , Zerman Nicoletta , Pettini Francesco , Muzio Lorenzo Lo , Cosola Michele Di , Santacroce Luigi , Ballini Andrea
Published: October 2022

Background:

Osseo-integrated implants provide effective treatment results for edentulous. However, despite the high success and survival rates of dental implants, several factors, such as poor oral hygiene and history of periodontal disease, and systemic diseases, such as diabetes mellitus, could influence the outcome of the treatment. In fact, poor glycemic control can affect the healing process. Diabetes mellitus is considered a relative contraindication for dental implant therapy due to the fact that the success rates of the implants seem to be lower in diabetic patients, even if there is no total agreement among the results reported in the literature. The analysis of peri-implant inflammation indices, bone loss around the implant and glycemic index can provide us with useful information on the relationship between glycaemia in diabetic patients and the course of peri-implantitis, as well as implant success in the short term.

Objective:

The purpose of this review is to establish how peri-implant inflammation parameters vary in diabetic versus non-diabetic patients.

Methods:

This review was conducted on the basis of PRISMA. The search was conducted by three independent reviewers searching for keywords in three databases: PubMed, Scopus, Web Of Sciences (WOS), and the Cochrane Central Register of Controlled Trial.

Results:

a total of 1159 records were identified and 11 articles were included in the qualitative analysis.

Conclusion:

The analysis of the extracted data from the included studies suggests that some peri-implant inflammation indices, such as bleeding on probing and bone loss around the implant, appear to be increased in diabetic patients with glycometabolic decompensation, compared with control not affected by diabetes mellitus.
Systematically Identifying Communication Deficits in Youth
Under Psychiatric Care Through a Self-Report Scale
Authors: Nagy Lauren Rae , Upadhyay Anu , Petti Theodore
Published: October 2022

Background:

Communication disorders are associated with psychopathology
and social distress in adolescents, yet moderate or less severe deficits
often go undiagnosed. Data from a quality improvement initiative was analyzed
from the Communication Perception Estimate Scale (CoPES), a self-report scale for
receptive-expressive and pragmatic language deficits in youth receiving mental
health services.

Objective:

To identify the frequency of communication deficits (CDs) among youth
in psychiatric care and identify patterns of self-reported symptoms. The scale may
be used as a clinical screening tool for Language disorder and Social (Pragmatic)
communication disorder.

Methods:

CoPES is a 31-item scale administered to 318 adolescents 11-18 years
old, asking questions about receptive-expressive and pragmatic CDs. In the first 12
items, subjects identified the frequency of communication disorder symptoms using
a forced-choice scale; in the following items, frustration with CDs, yes or no for
earlier intervention, and current interest in getting help for CDs. Respondents are
from five representative clinical services.

Results:

Patients were divided into self-identified groups: 14.5% significant
Receptive-Expressive deficits only (R-ED); 6.6% significant Pragmatic deficits
only (PD); 29.9% Both significant Receptive-Expressive and Pragmatic deficits
(BCD); and 49.1% with limited or no deficits (NCD). The R-ED group expressed
high rates of frustration and requests for help with Receptive-Expressive deficits.
The PD group reported elevated rates of frustration in both areas. The BCD group
indicated significantly more frustration and requests for help with both language
areas compared to the NCD group.

Conclusion:

This data supports the need for greater awareness and consideration of
communication disorders in youth presenting for psychiatric care.
Curcumin-loaded Hydrotropic Solid Dispersion Topical Gel Development
and Evaluation: A Greener Approach Towards Transdermal Delivery of
Drugs
Authors: Tripathi Devika , Mishra Sangeeta , Rai Awani Kumar , Sahoo Jagannath , Sharma Dinesh Kumar , Singh Yadvendra
Published: October 2022

Aims and Background:

Curcumin's poor water solubility still presents a challenge. Because of
Curcumin's instability in solubilizing solvents, using a non-sustainable solvent and dissolved oxygen in
the solution might be the problem. Thus, considering all facts, looking for a promising alternative solvent
medium is in need. Indeed, a solution of hydrotropic agent has been assessed recently. Hydrotropic agents
are the best replacements for organic solvents. These are eco-friendly, safe, and non-toxic agents. Hence,
the presented research focuses on improving the solubility of Curcumin through a hydrotropic solid dispersion
approach. Amazingly, Curcumin showed a significant solubility enhancement in sodium salicylate
hydrotropic Solution. Sodium salicylate hydrotrope ensured the stability of Curcumin in Solution,
maintained homogeneity, and exhibited antioxidant properties. Hydrotropy combined with the solid dispersion
technique is a simple and effective way to improve the bioavailability of Curcumin. Hydrotropic
solid dispersion-loaded curcumin topical gel was developed to achieve transdermal delivery of Curcumin.
Solid dispersion was prepared by solvent evaporation method and evaluated for in-vitro performance. Invitro
drug dissolution, drug content, FTIR, and XRD were carried out for the prepared HSD.

Objective:

The selected HSD (1:4) was loaded into a topical gel by dispersion method, and in-vitro parameters
like drug content, Spreadability, pH, rate of drug dissolution, and drug content were performed.

Methods:

The solubility study has substantially enhanced the solubility of Curcumin in a 2M sodium
salicylate hydrotropic solution. Sodium salicylate was compatible with formulating the solid dispersion.
Hydrotropic solid dispersion was successfully prepared in 1:4 ratios. XRD results have shown the amorphous
nature of Curcumin in the presence of sodium benzoate. The dissolution studies have shown improved
release compared to pure Curcumin and PM (1:4). The prepared HSD was then incorporated into a
gel by dispersion method using carbopol 934 and hydroxypropyl methylcellulose as a gelling agent. The
Cur-HSD gel was homogeneous and transparent in appearance.

Result:

The gel showed excellent Spreadability and drug content of 94.2 with 90.21% of percent drug
release for 120 min and showed improved release in the presence of hydrotrope for improved topical delivery
of Curcumin.

Conclusion:

Thus, to enhance the topical delivery of poorly soluble phytoconstituents, hydrotropes are
suggested as a greener approach and to be applied for other poorly soluble phytoconstituents.
Young digital citizen answers: Can online learning improve the quality of civic education learning?
Authors: Halimi Muhammad , Rahmat Rahmat , Nugraha Restu Adi , Pratiwi Elda Dwi
Published: October 2022

Technological developments have an impact on various fields, in education particularly, the 21st-century learning requires lectures and learners to be creative and innovative in utilizing digital media effectively, by using the right methods, the learning process in the digital era will be carried out optimally, to improve the quality of learning by learning objectives. This research used a mixed design approach with a survey as its main method. The participants of this study were lecturers and students of the PKn UPI Study Program using online learning in an online learning system (SPADA UPI) and Integrated Online Learning System (SPOT UPI) at Universitas Pendidikan Indonesia. The results show that online learning can improve the quality of Civics learning if technology can be integrated into the Civics learning curriculum, lectures who can use digital media and digital literacy, and teaching materials that can develop 21st-century civic competencies to prepare young citizens in facing the era of disruption. Students as young citizens can be directed to master digital citizenship skills so that they can become citizens who have democratic, wise, and responsible competencies in the digital era.
Online civic engagement: Fostering citizen engagement through social media
Authors: Mulyono Budi , Affandi Idrus , Suryadi Karim , Darmawan Cecep
Published: October 2022

The Industrial Revolution 4.0, which makes the internet its backbone, has accelerated the process due to the Covid-19 pandemic which forced citizens to shift all their activities to the digital world, including the involvement of citizens in responding to public discourse. Citizens' public discourses that previously took place in real public spaces have now shifted to digital spaces, one of which is social media. To bridge these changes, a conceptualization of civic engagement is needed through a digital platform. The online citizen involvement was later referred to as online civic engagement, namely civic engagement activities specifically carried out by digital citizens involving several types of digital media, one of which is social media. This literature study provides a clearer picture of the forms of community interaction through social media that go beyond what is known as “slacktivism”. When many democracies are faced with the problem of decreasing citizen participation in politics, social media comes with a new form of civic interaction with what is meant by online civic engagement.
A New Approach to Enhancing Engagement in eHealth Apps
Authors: Oakley-Girvan Ingrid , Docherty John P
Published: October 2022

This viewpoint presents a 3-phase conceptual model of the process of user engagement with eHealth apps. We also describe how knowledge gleaned from psychosocial, behavioral, and cognitive science can be incorporated into this model to enhance user engagement with an eHealth app in each phase of the engagement process.
Promoting hand hygiene during the COVID-19 pandemic: A parallel randomized trial for the optimization of the Soapp app (Preprint)
Authors: Baretta Dario , Amrein Melanie Alexandra , Baeder Carole , Ruschetti Gian Giacomo , Ruettimann Carole , Del Rio Carral Maria , Fabian Carlo , Inauen Jennifer
Published: October 2022

BACKGROUND

Hand hygiene is an effective behavior for preventing the spread of the respiratory disease COVID-19, and was included in public health guidelines worldwide. Behavior change interventions addressing hand hygiene have the potential to support the adherence to public health recommendations and thereby prevent the spread of COVID-19. However, randomized trials during a pandemic are largely absent, wherefore there is little knowledge about the most effective strategies to promote hand hygiene during an ongoing pandemic. The present study addresses this gap by presenting the results of the optimization phase of a Multiphase Optimization Strategy of Soapp, a smartphone app to promote hand hygiene in the context of the COVID-19 pandemic.

OBJECTIVE

The goal was to identify the most effective combination and sequence of three theory- and evidence-based intervention modules (Habit, Motivation, Social Norms) to promote hand hygiene. To this aim, nine versions of Soapp were developed (conditions) and two optimization criteria were defined: i) condition with largest increase in hand hygiene at follow-up and ii) condition with highest engagement, usability and satisfaction based on quantitative and qualitative analyses.

METHODS

The study design was a parallel randomized trial with nine intervention conditions defined by the combination of two intervention modules and their sequence. The trial was conducted from March to August 2021 with interested participants of the Swiss general population (N = 232 randomized). Randomization was performed by Qualtrics and blinding was ensured. The duration of the intervention was 34 days. The primary outcome was self-reported hand hygiene at follow-up, assessed via an electronic diary. Secondary outcomes were user engagement, usability and satisfaction, assessed at follow-up. Participants were further invited for semi-structured exit interviews (n = 9). A set of Anovas was performed to test the main hypotheses while thematic analysis was performed to analyze the qualitative data.

RESULTS

Results showed a significant increase in hand hygiene over time across all conditions. There was no interaction effect of time and intervention condition. Likewise, no between-group difference in engagement, usability and satisfaction emerged. Seven themes (e.g., “variety and timeliness of the workload”, “social interaction”) were found in the thematic analysis.

CONCLUSIONS

The current findings evidenced no effect of intervention condition of a habit, motivation and social norms module on hand hygiene, engagement, usability and satisfaction. In the absence of quantitative differences, we relied on the results from the thematic analysis to select the best version of Soapp for the evaluation phase.

CLINICALTRIAL

NCT04830761

INTERNATIONAL REGISTERED REPORT

RR2-10.1136/bmjopen-2021-055971
Acute Spontaneous Colonic Perforation in a Case of Newly Confirmed Scleroderma: Case Report (Preprint)
Authors: Goodwin Glenn , Ryckeley Christian , Fox Davide , Ashley Michael , Dubensky Laurence , Danckers Mauricio , Slesinger Todd
Published: October 2022

UNSTRUCTURED

Scleroderma is a group of autoimmune diseases that principally affects the skin, blood vessels, muscles, and viscera. One of the more well-known subgroups of scleroderma is the limited cutaneous form of the multisystem connective tissue disorder known as CREST (calcinosis, Raynaud phenomenon, esophageal dysmotility, sclerodactyly, and telangiectasis) syndrome. In this report, we present a case of a spontaneous colonic bowel perforation in a patient with incomplete features of CREST. Our patient underwent a complicated hospital course involving broad-spectrum antibiotic coverage, surgical hemicolectomy, and immunosuppressives. She was eventually discharged home with a return to functional baseline status after esophageal dysmotility confirmation via manometry. Physicians managing patients with scleroderma ensuing to an emergency department encounter must anticipate the multitude of complications that can occur, as was seen in our patient. The threshold for pursuing imaging and additional tests, in addition to admission, should be relatively low, given the extremely high rates of complications and mortality. Early multidisciplinary involvement with infectious disease, rheumatology, surgery, and other respective specialties is crucial for patient outcome optimization.
Engagement with mHealth alcohol interventions: User perspectives on an app or chatbot-delivered program to reduce drinking (Preprint)
Authors: Mertz Robyn N , Edwards Alexandra E , Dulin Patrick L , King Diane K
Published: October 2022

BACKGROUND

Research suggests participant engagement is a key mediator of mHealth alcohol interventions’ effectiveness. Understanding the features that promote user engagement is critical to maximizing the effectiveness of mHealth-delivered interventions.

OBJECTIVE

The purpose of this study was to identify factors related to mHealth alcohol intervention utilization and engagement amongst hazardous-drinking participants who were randomized to use either an app or Artificial Intelligence (AI) chatbot-based intervention for reducing drinking.

METHODS

We conducted semi-structured interviews with 20 participants who used the app or chatbot for three months, utilizing thematic analysis to identify common facilitators of their continued use as well as factors that diminished engagement.

RESULTS

Participants of both interventions reported that tracking their drinking, receiving feedback about their drinking, feeling accountable; and daily notifications about high-risk drinking times and reminders to track their drinking promoted continued engagement. Positivity, personalization, gaining insight into their drinking, and daily tips were stronger facilitator themes among bot users, indicating these may be strengths of the AI chatbot-based intervention when compared to a user-directed app. While tracking drinking was a theme among both groups, it was more salient among app users, potentially due to the option to quickly track drinks in the app that was not present with the conversational chatbot. Notification glitches, technology glitches, and difficulty with tracking drinking data were barriers for both users. Lengthy setup processes was a stronger barrier for app users. Repetitiveness of the bot conversation, receipt of non-tailored daily tips, and inability to self-navigate to desired content were reported as barriers by bot users. Participants in both conditions reported that their engagement with a behaviorally focused mHealth intervention was encouraged by tailored feedback about their alcohol use and timely notifications.

CONCLUSIONS

To maximize engagement with AI interventions, future developers should include tracking to reinforce behavior change self-monitoring, and be mindful of repetitive conversations, lengthy setup, and pathways that limit self-directed navigation.

CLINICALTRIAL

ClinicalTrials.gov NCT04447794

INTERNATIONAL REGISTERED REPORT

RR2-10.2196/33037
Effect of a Mobile App–Based Urinary Incontinence Self-Management Intervention Among Pregnant Women in China: Pragmatic Randomized Controlled Trial (Preprint)
Authors: Chen Ling , Zhang Danli , Li Tiantian , Liu Sha , Hua Jie , Cai Wenzhi
Published: October 2022

BACKGROUND

Urinary incontinence (UI) is a highly prevalent health concern commonly observed during and after pregnancy that can substantially impact women’s physical and psychological well-being and quality of life. Owing to its numerous advantages, mobile health may be a promising solution; however, it is unclear whether the app-based intervention can effectively improve UI symptoms during and after pregnancy.

OBJECTIVE

This study aimed to evaluate the effectiveness of the Urinary Incontinence for Women (UIW) app–based intervention for UI symptom improvement among pregnant women in China.

METHODS

Singleton pregnant women without incontinence before pregnancy who were aged ≥18 years and between 24 and 28 weeks of gestation were recruited from a tertiary public hospital in China and were randomly allocated (1:1) to either an experimental group (n=63) or a control group (n=63). The experimental group received the UIW app intervention and oral pelvic floor muscle training (PFMT) instructions, whereas the control group received oral PFMT instructions alone. Neither the participants nor the researchers were blinded to the intervention. The primary outcome was UI severity. The secondary outcomes included quality of life, self-efficacy with PFMT, and knowledge of UI. All data were collected at baseline, 2 months after randomization, and 6 weeks post partum through electronic questionnaires or by checking the electronic medical record system. Data analysis followed the intention-to-treat principle. A linear mixed model was used to examine the intervention effect on primary and secondary outcomes.

RESULTS

Participants in the experimental and control groups were comparable at baseline. Of the 126 overall participants, 117 (92.9%) and 103 (81.7%) women completed follow-up visits at 2 months after randomization and 6 weeks after delivery, respectively. A statistically significant difference in UI symptom severity was observed between the experimental group and control group (2 months after randomization: mean difference −2.86, 95% CI −4.09 to −1.64, P<.001; 6 weeks post partum: mean difference −2.68, 95% CI −3.87 to −1.49, P<.001). For the secondary outcomes, a statistically significant intervention effect on the quality of life, self-efficacy, and UI knowledge was found at the 2-month follow-up (all P<.05) and 6 weeks post partum (all P<.001).

CONCLUSIONS

The app-based UI self-management intervention (UIW) effectively improved UI symptom severity, quality of life, self-efficacy with PFMT, and knowledge of UI during the late pregnancy and early postnatal periods. Larger multicenter studies with a longer postpartum follow-up are required to further extend these findings.

CLINICALTRIAL

Chinese Clinical Trial Registry ChiCTR1800016171; http://www.chictr.org.cn/showproj.aspx?proj=27455

INTERNATIONAL REGISTERED REPORT

RR2-10.2196/22771
Exploring Health Care Provider Readiness for Implementing Telehealth Services Beyond the COVID-19 Pandemic: A Mixed-Method Study in Indonesia (Preprint)
Authors: Alfian Sofa D , Khoiry Qisty A , Isman Hasna S. M , Iskandarsya Aulia , Pradipta Ivan S , Abdulah Rizky
Published: October 2022

BACKGROUND

The coronavirus disease 2019 pandemic accelerated digital health transformation, forcing health care providers to immediately implement telehealth services without adequate assessment of their readiness.

OBJECTIVE

This study aims to explore the readiness of health care providers to implement telehealth services in Indonesia.

METHODS

We employed a sequential mixed methods explanatory study design. A cross-sectional survey using the translated and validated Telehealth Readiness Assessment (TRA) tool was conducted among general practitioners and pharmacists from private clinics in Bandung City, Indonesia. This was followed by a qualitative study using in-depth interviews and focus group discussions (FGDs) to explore the underlying reasons among those who showed low readiness observed from quantitative results. Quantitative and qualitative data analyses were performed for each type of health care provider.

RESULTS

In total, 63 general practitioners and 86 pharmacists, a majority of whom were female (63.5% and 72.1% among general practitioners and pharmacists, respectively), completed the survey. Most of the general practitioners showed moderate readiness, whereas most of the pharmacists showed high readiness to implement telehealth services. No significant correlations were observed between readiness to implement telehealth services and age, sex, education level, and duration of experience in general practice and pharmacy (p > 0.05). A total of three females aged between 26 and 50 years participated in the in-depth interviews and FGD. Among those who showed low readiness, organizational leadership, financial considerations, operational difficulties, staff engagement, and patient involvement were mentioned as the main reasons. Differences in these underlying reasons were observed between general practitioners and pharmacists.

CONCLUSIONS

Differences were observed in the levels at which general practitioners and pharmacists were ready to implement telehealth services. The underlying reasons for the low readiness are specific to the type of health care provider and rely on organizational and technological factors, independent of their sociodemographic factors.
Evaluasi penerapan sistem informasi manajemen rumah sakit (simrs) di rsud praya kabupaten lombok tengah nusa tenggara barat
Authors: Beny Beny Binarto
Published: October 2022

Latar belakang: Evaluasi menyeluruh untuk mengetahui bagaimana penerapan sistem informasi manajemen rumah sakit (SIMRS) di unit kerja rumah sakit. Penerapan sistem informasi SIMRS di rumah sakit sangat penting untuk mencapai layanan berkualitas. Sehingga rumah sakit perlu untuk mengembangkan SIMRS dengan mempertimbangkan faktor-faktor yang mempengaruhi dan manfaat penggunaan SIMRS.Metode Penelitian: Jenis penelitian kuantitatif pendekatan studi kasus dilakukan dengan menggunakan kerangka human, organization, technology–Fit (HOT-fit). Jumlah sampel sebanyak 35 sampel yang diambil yaitu pengguna SIMRS. Analisis data dilakukan dengan uji regresi linier berganda.Hasil: Berdasarkan hasil olah data diperoleh nilai Sig.t < 0,05, maka disimpulkan bahwa secara parsial ada pengaruh signifikan antara faktor human, organization, technology, pengetahuan pengguna, dan regulasi terhadap Net Benefit SIMRS. Hasil olah data diperoleh nilai Sig.F < 0,05, artinya secara simultan ada pengaruh signifikan antara faktor human, organization, technology, pengetahuan pengguna, dan regulasi terhadap Net Benefit SIMRS.Kesimpulan: Pemanfaatan penerapan SIMRS di RSUD Praya Kabupaten Lombok Tengah Nusa Tenggara Barat hasil evaluasinya belum berjalan dengan maksimal. Faktor human, organization, technology, pengetahuan pengguna, dan regulasi berpengaruh signifikan secara parsial maupun simultan terhadap Net Benefit SIMRS (p-value = 0,000 < Level of Significant = 0,05).Kata kunci: Evaluasi Sistem Informasi Manajemen Rumah Sakit (SIMRS), HOT-fit Model, dan Net Benefit.
Diagnostic amyloid light chain amyloidosis hospitalizations associated with high acuity and cost: analysis of the Premier Healthcare Database
Authors: D’Souza Anita , Broder Michael S , Bognar Katalin , Chang Eunice , Tarbox Marian H , Quock Tiffany P
Published: October 2022

Aim:
Estimate the frequency and costs of diagnostic admissions among hospitalized patients with amyloid light chain (AL) amyloidosis.
Materials & methods:
This retrospective analysis used nationally representative hospital discharge data from 2017 to 2020 to report resource use and cost for hospitalizations during which AL amyloidosis was diagnosed.
Results:
Of 1341 admissions, 17.6% were diagnostic. Bone marrow (79.5%) and kidney (44.9%) biopsies were the most common qualifying biopsies. Diagnostic hospitalizations had longer length of stay (14.5 vs 8.4 days; p < 0.001) and higher cost ($40,052 [USD] vs $24,360; p < 0.001) than nondiagnostic ones.
Conclusion:
Diagnostic admissions are more likely to be urgent/emergent, require longer stays and have higher costs compared with hospitalizations in known AL amyloidosis patients. Improved diagnostic pathways toward early diagnosis are needed.
Scoping reviews: una nueva forma de síntesis de la evidencia
Authors: Lopez-Cortes Oscar David , Betancourt-Núñez Alejandra , Bernal Orozco María Fernanda , Vizmanos Barbara
Published: October 2022

Las scoping reviews nacen a partir de la necesidad de sintetizar evidencias desde un objetivo de revisión más amplio que el de las revisiones sistemáticas, pero sin perder su rigor metodológico; requieren partir de un protocolo previamente registrado en el que se incluyen los criterios de búsqueda, inclusión y exclusión. Las scoping reviews se caracterizan por revisar contenidos amplios respondiendo a preguntas de población-contexto-concepto (PCC) enfocadas en conceptos clave, metodologías específicas y lagunas del conocimiento, con fuentes de información heterogéneas (ensayos clínicos aleatorizados, estudios observacionales, información de blogs, sitios web, entrevistas, opiniones, congresos, estudios de metodología cualitativa, etc.) y presentan como producto final una síntesis informativa de toda la evidencia recopilada. Además de su utilidad en el mapeo de áreas emergentes del conocimiento, las scoping reviews son de utilidad en los trabajos académicos, pues permiten plantear los antecedentes y marco teórico para el desarrollo de un estudio (anteproyecto, proyecto de tesis), así como identificar vacíos de conocimiento que, a su vez, conllevan realizar nuevas preguntas de investigación y desarrollar nuevos estudios originales o revisiones sistemáticas.
Perfis artísticos em dança
Authors: Bragato Marcos , Chellappa Thiago , Stefferson Michael
Published: October 2022

Este estudo tem por objeto a descrição de traços presentes em perfis artísticos em dança que reconhecemos por sua estabilidade e persistência. Toma como primeira investidura os casos de Lac (Sandro Borelli) e Les Poupées (Marta Soares). Com o modelo do Big Five – os cinco grandes fatores da personalidade – é possível o recorte de grupos de gestos e movimentos, comportamento não verbal, os que persistem como ação e reação, os quais são receptivos e reativos à própria ação, os insistentes a olho nu. Fazemos uso da observação e, consequentemente, interpretação a partir de gravação em DVDs em sistema de forward and rewind – avançar e retroceder – e freeze, o congelar das imagens de gravações em vídeo. Os perfis em arte são habitualmente estudados em acordo com o grau de aproximação e afastamento de um determinado fator da personalidade do artista e não como motivo independente no produto artístico.
PDTC ameliorates decompression induced-lung injury caused by unsafe fast buoyancy ascent escape via inhibition of NF-κB pathway
Authors:   Second Military Medical University, Shanghai, China, Wang Hai-Tao ,   Department of Diving Medicine, Naval Medical Research Institute, Shanghai, China, Fang Yi-Qun ,   Second Military Medical University, Shanghai, China,   Department of Diving Medicine, Naval Medical Research Institute, Shanghai, China, Yu Pu ,   Second Military Medical University, Shanghai, China,   Department of Diving Medicine, Naval Medical Research Institute, Shanghai, China, Bao Xiao-Chen ,   Second Military Medical University, Shanghai, China,   Department of Diving Medicine, Naval Medical Research Institute, Shanghai, China, Li Kai-Cheng ,   Second Military Medical University, Shanghai, China,   Department of Diving Medicine, Naval Medical Research Institute, Shanghai, China, Yao Jian ,   Second Military Medical University, Shanghai, China,   Department of Diving Medicine, Naval Medical Research Institute, Shanghai, China, Li Ci ,   Second Military Medical University, Shanghai, China,   Department of Diving Medicine, Naval Medical Research Institute, Shanghai, China, Yuan Heng-Rong ,   Second Military Medical University, Shanghai, China,   Department of Diving Medicine, Naval Medical Research Institute, Shanghai, China
Published: October 2022

Nuclear factor kappa B (NF-κB) is the critical transcriptional factor in the pathogenesis of acute lung injury (ALI). NF-κB regulates the expression changes of inflammatory factors such as tumor necrosis factor alpha (TNF-α), interleukin-1β (IL-1β) and interleukin 6 (IL-6). In a previous study we showed that decompression sickness (DCS) caused by simulated unsafe fast buoyancy ascent escape (FBAE) could result in ALI, which was characterized by expression changes of inflammatory factors in rat lung tissue. The purpose of the present work was to study the roles of NF-κB and TNF-α in the process of DCS-induced rat lung injury caused by simulated unsafe FBAE. The research methods aimed to detect the rat lung tissue messenger ribonucleic acid (mRNA) and protein level variations of NF-κB, inhibitory κB (IκB), TNF-α, IL-1β, IL-6, IL-10 and IL-13 by using pretreatment of the NF-κB inhibitor pyrrolidine dithiocarbamate (PDTC) and TNF-α antibody (Ab). Our experimental results demonstrated that PDTC could improve the survival rate of the rats with DCS caused by unsafe FBAE more effectively than TNF-α Ab. However, the inhibition of TNF-α Ab on the nuclear translocated protein expression of NF-κB was more effective than PDTC. Both PDTC and TNF-α Ab can abrogate the increment of the rat lung tissue mRNA levels of TNF-α, IL-1β, IL-6 and protein levels of NF-κB, TNF-α, IL-1β effectively and increase the rat lung tissue content of IκB significantly. In conclusion, TNF-α-mediated NF-κB signaling may be one of the critical signaling pathways in the pathogenesis of DCS-induced rat lung injury caused by simulated unsafe FBAE. PDTC may ameliorate this type of injury partly through inhibiting the NF-κB pathway.
A pilot study evaluating knowledge of indications for hyperbaric oxygen therapy
Authors:   McLaren Greater Lansing Wound and Hyperbaric Center, Lansing, Michigan U.S., Jones Mark W
Published: October 2022

A pilot study was conducted in mid-Michigan to evaluate know-ledge of appropriate hyperbaric oxygen therapy referrals in “first contact” physicians who did not have additional hyperbaric training. The hypothesis for this study is that many first-contact physicians have little or no exposure to hyperbaric oxygen (HBO2) therapy and its indications. A survey was distributed regarding accepted indications combined with conditions not currently approved or contraindicated for HBO2. Answers were tallied for correct identification of approved indications, missed approved indications, and inappropriate identification of unapproved indications. Ninety surveys were distributed and 62 physicians of various specialties responded. There were notably high percentages of missed indications, as high as 93%. Many emergent/urgent indications were missed as well. The highest percentage of wrong indications was 32%. Very concerning is the 13% who chose refractory pneumothorax as a condition responsive to HBO2 therapy. This study showed significant lack of familiarity of HBO2 treatment indications among physicians who did not have additional hyperbaric training. Inclusion of hyperbaric education during residencies may increase HBO2 referrals and improve outcomes for various disorders.