bluuebunny/crossref_metadata_2025 huggingface dataset:
The Effect of Mobile Portfolio (M-Portfolio) Supported Mastery Learning Model on Students’ Achievement and Their Attitudes towards Using Internet
Authors: Ozdemir Oguzhan , Erdemci Husamettin
Published: February 2017

The term mobile portfolio refers to creating, evaluating and sharing portfolios in mobile environments. Many of the states that pose an obstacle for portfolio usage are now extinguished through mobile portfolios. The aim in this research is to determine the effect of mobile portfolio supported mastery learning model on students’ success and attitudes towards using internet. The research was carried out in the Academic Year 2014-2015 with students, taking Computer-I course at Primary School Teacher Education and Social Sciences Teaching Departments in Faculty of Education in Siirt University. The Internet Usage Attitudes Scale developed by Tavsancil & Keser (2002), was used to determine student attitudes towards internet usage. The scale was prepared as a five point Likert type scale. An academic achievement test developed by researchers was used to determine achievement of course. The data analysis methods used in this study were average, standard deviation, independent groups t-test and dependent groups t-test. As a result of research, the effect of mobile portfolio supported mastery learning model on students’ academic achievement was found to be positive. Furthermore, use of mobile portfolio among students tested in research, a positive increase was seen in their attitudes towards internet use. As a result of the data analysis, this difference shows no significant difference. According to the findings recommendations have been made.
Perceptions Regarding the Care and Education of Children from Birth to Age Three among Students of Early Childhood Education: Changes between Pre-training and Post-training
Authors: Russo-Zimet Gila , Gilat Itzhak
Published: February 2017

Many theoreticians focus on understanding the belief system regarding the mind of the learner – The Mind Theory. Olson & Brunner (1996) referred to this belief system as "folk psychology". They named the processes required to promote learners' knowledge and understanding "folk pedagogy". In their opinion, folk pedagogy reflects the learners' folk psychology. In other words, the study of folk psychology has focused on how everyday people—those without formal training in the various academic fields of science—go about attributing mental states. This domain has primarily been centered on intentional states reflective of an individual's beliefs and desires.The present study set up to characterize the folk psychology (contains expressions and summaries of various settings as a way of informally shaping quite general meanings or organizing experience) and the folk pedagogy, which deals with where, when and why people teach or educate one another in various ways for the sake of making out of things (Olson & Bruner, 1996) in early childhood education students with respect to education and care during the first three years of life and examine whether these views change during the course of their formal education.The sample comprised of 379 students of education majoring in early childhood education at three colleges in Israel. Data was gathered by a structured questionnaire examining five domains: the impact of year of life on child development, domains affecting child development, care and educational settings, care and educational methods and the role of caregivers. The findings reveal that the perceived influence of family care centers and daycare centers influence on child development decreases between the beginning and the end of their studies. The perceived effectiveness of coping through awareness increased, while strict coping methods were perceived as less effective after the training.
Desperate to Quit: A Narrative Analysis of Burnout and Recovery in High-Performance Sports Coaching
Authors: Olusoga Peter , Kenttä Göran
Published: February 2017

This study investigated how the experiences of two elite coaches contributed to and shaped their stories of burnout and withdrawal from high performance coaching. The coaches whose narratives we explore were both middle-aged head coaches, one in a major team sport at the highest club level, and one in an individual Olympic sport at international level. Through a thematic narrative analysis, based on in-depth interviews, the stories of the two coaches are presented in four distinct sections: antecedents, experiences of coaching with burnout symptoms, withdrawal from sport, and the process of recovery and personal growth. These narratives have implications for high performance coaching, such as the importance of role clarity, work-home inference, counseling, mentoring, and social support as means to facilitate recovery, and the need for additional research with coaches who have left sport, to gain a more comprehensive understanding of the complete burnout-recovery process.
The Effects of REBT, and the Use of Credos, on Irrational Beliefs and Resilience Qualities in Athletes
Authors: Deen Saqib , Turner Martin James , Wong Rebecca S.K.
Published: February 2017

The use of rational emotive behavior therapy (REBT) in sport psychology has received little attention in research to date, but is steadily growing. Therefore, to further add to the building body of research, this study examines the efficacy of REBT (comprising five counseling sessions, and four homework assignments) in decreasing self-reported irrational beliefs, and increasing self-reported resilient qualities in five elite squash players from Malaysia. The study uses a single-case multiple-baseline across-participants design. Visual and graphical analyses revealed that REBT reduced self-reported irrational beliefs significantly in all athletes, and raised self-reported resilient qualities significantly in some athletes. Athlete’s feedback, reflections on the usage of REBT, Athlete Rational Resilience Credos, and the practice of sport psychology across cultures are discussed, along with guidance for the future use of REBT in relevant settings.
Regulating Preperformance Psychobiosocial States with Music
Authors: Middleton Thierry R.F. , Ruiz Montse C. , Robazza Claudio
Published: February 2017

The purpose of the study was to investigate the effects of music on swimmers’ preperformance psychobiosocial states. A purposeful sample of competitive swimmers (N = 17) participated in a 5-week intervention grounded in the individual zones of optimal functioning (IZOF) model. Findings showed that (a) preperformance psychobiosocial states differentiated between best and worst performances, (b) swimmers improved their ability to regulate preperformance states through the use of music, and (c) the use of music had a positive impact on swimmers’ perceived effectiveness of preperformance routines. Furthermore, swimmers’ qualitative reports indicated that music use was made more purposeful due to the introduction of a music intervention. The current study provides preliminary evidence in support of the use of music during preperformance routines as an effective tool to regulate athletes’ preperformance states. Athletes are encouraged to engage in the process of carefully selecting music in accordance with individualized profiles related to optimal performance states.
Yamaguchi syndrome presenting as atrioventricular nodal re-entrant tachycardia in an African-American patient
Authors: Candelario Nellowe , Penalver Jorge , Sen Mitali
Published: February 2017

Apical hypertrophic cardiomyopathy (Yamaguchi syndrome) is a rare subtype of hypertrophic cardiomyopathy. The syndrome is more common in Japan where it was first described. Outside Asia, it is a very rare cause of hypertrophic cardiomyopathy. Apical hypertrophic cardiomyopathy is usually detected incidentally and has a good long-term outcome. We present a case of apical hypertrophic cardiomyopathy in an African-American patient manifesting as atrioventricular nodal re-entrant tachycardia.
Robotic partial nephrectomy for duplex kidney with ectopic ureter draining in the vagina in an adult patient with urinary incontinence
Authors: Mahmood Humza , Hadjipavlou Marios , Das Raj , Anderson Chris
Published: February 2017

A duplex kidney system with an ectopic ureter draining into the vagina is a congenital malformation that typically presents as refractory urinary incontinence. Diagnosis is often difficult to establish and delayed due to a low incidence. We present the case of a patient aged 26 years with a life-long history of persistent urinary incontinence. Initial presentation was at childhood; however, the diagnosis went undetermined for 22 years. CT urography revealed a duplex kidney with an atrophic upper pole associated with an ectopic ureter that drained into the vaginal vault. This is the first description of such a case being managed successfully via a robot-assisted partial nephrectomy approach. Ectopic ureteral duplication should be considered in the differential diagnosis for young women with refractory urinary incontinence. Robotic partial nephrectomy is a safe and effective technique to manage such cases.
Primary gastric plasmacytoma: a rare entity
Authors: Oliveira Rui Caetano , Amaro Pedro , Julião Maria José , Cipriano Maria Augusta
Published: February 2017

Extramedullary plasmacytomas (EP) are tumours composed by a monoclonal population of plasma cells that arise in extraosseus tissues, comprising <5% of all plasma cell neoplasms. Usually, EP arise in the head and neck region, and the stomach is the second most common location—gastric plasmacytoma (GP). Clinical and radiological manifestations are unspecific and may mimic other tumours like gastric adenocarcinomas, gastric stromal tumours and lymphomas, mainly marginal cell lymphoma (MALT lymphoma) and usually definitive diagnosis is provided by pathological evaluation. We present a case of primary GP, discovered incidentally as a polypoid lesion. Tumour was composed by sheets of mature and immature plasmocytes positive for CD138 on immunohistochemistry, withoutHelicobacter pyloriidentification. The patient is alive 6 years later and without tumour relapse.
Improvement and Neuroplasticity after Combined Rehabilitation to Forced Grasping
Authors: Arima Michiko , Ogata Atsuko , Kawahira Kazumi , Shimodozono Megumi
Published: February 2017

The grasp reflex is a distressing symptom but the need to treat or suppress it has rarely been discussed in the literature. We report the case of a 17-year-old man who had suffered cerebral infarction of the right putamen and temporal lobe 10 years previously. Forced grasping of the hemiparetic left upper limb was improved after a unique combined treatment. Botulinum toxin type A (BTX-A) was first injected into the left biceps, wrist flexor muscles, and finger flexor muscles. Forced grasping was reduced along with spasticity of the upper limb. In addition, repetitive facilitative exercise and object-related training were performed under low-amplitude continuous neuromuscular electrical stimulation. Since this 2-week treatment improved upper limb function, we compared brain activities, as measured by near-infrared spectroscopy during finger pinching, before and after the combined treatment. Brain activities in the ipsilesional sensorimotor cortex (SMC) and medial frontal cortex (MFC) during pinching under electrical stimulation after treatment were greater than those before. The results suggest that training under electrical stimulation after BTX-A treatment may modulate the activities of the ipsilesional SMC and MFC and lead to functional improvement of the affected upper limb with forced grasping.
Interval-Valued Intuitionistic Fuzzy Ordered Weighted Cosine Similarity Measure and Its Application in Investment Decision-Making
Authors: Liu Donghai , Chen Xiaohong , Peng Dan
Published: February 2017

We present the interval-valued intuitionistic fuzzy ordered weighted cosine similarity (IVIFOWCS) measure in this paper, which combines the interval-valued intuitionistic fuzzy cosine similarity measure with the generalized ordered weighted averaging operator. The main advantage of the IVIFOWCS measure provides a parameterized family of similarity measures, and the decision maker can use the IVIFOWCS measure to consider a lot of possibilities and select the aggregation operator in accordance with his interests. We have studied some of its main properties and particular cases such as the interval-valued intuitionistic fuzzy ordered weighted arithmetic cosine similarity (IVIFOWACS) measure and the interval-valued intuitionistic fuzzy maximum cosine similarity (IVIFMAXCS) measure. The IVIFOWCS measure not only is a generalization of some similarity measure, but also it can deal with the correlation of different decision matrices for interval-valued intuitionistic fuzzy values. Furthermore, we present an application of IVIFOWCS measure to the group decision-making problem. Finally the existing similarity measures are compared with the IVIFOWCS measure by an illustrative example.
Internuclear Ophthalmoplegia Secondary to Cocaine Abuse
Authors: Rabin Richard L. , Wasay Azeem , Biro Nicolas , Morcos Marcelle
Published: February 2017

Purpose. To report a case of internuclear ophthalmoplegia (INO) caused by cocaine.Method. We report a case of a 54-year-old female who presented with a left INO three days after snorting cocaine, and we review the literature.Results. MRI of the brain demonstrated several small abnormal foci in the pons on FLAIR and diffusion weighted imaging consistent with ischemic infarction. The patient’s symptoms remained stable throughout her hospitalization. She was sent to a rehabilitation facility and was lost to follow-up.Conclusion. In cases of extraocular movement abnormalities, it is important to inquire about recreational drug use.
The Benefit of Neuromuscular Blockade in Patients with Postanoxic Myoclonus Otherwise Obscuring Continuous Electroencephalography (CEEG)
Authors: Newey Christopher R. , Hornik Alejandro , Guerch Meziane , Veripuram Anantha , Yerram Sushma , Ardelt Agnieszka
Published: February 2017

Introduction. Myoclonus status epilepticus is independently associated with poor outcome in coma patients after cardiac arrest. Determining if myoclonus is of cortical origin on continuous electroencephalography (CEEG) can be difficult secondary to the muscle artifact obscuring the underlying CEEG. The use of a neuromuscular blocker can be useful in these cases. Methods. Retrospective review of CEEG in patients with postanoxic myoclonus who received cisatracurium while being monitored. Results. Twelve patients (mean age: 53.3 years; 58.3% male) met inclusion criteria of clinical postanoxic myoclonus. The initial CEEG patterns immediately prior to neuromuscular blockade showed myoclonic artifact with continuous slowing (50%), burst suppression with myoclonic artifact (41.7%), and continuous myogenic artifact obscuring CEEG (8.3%). After intravenous administration of cisatracurium (0.1 mg–2 mg), reduction in artifact improved quality of CEEG recordings in 9/12 (75%), revealing previously unrecognized patterns: continuous EEG seizures (33.3%), lateralizing slowing (16.7%), burst suppression (16.7%), generalized periodic discharges (8.3%), and, in the patient who had an initially uninterpretable CEEG from myogenic artifact, continuous slowing. Conclusion. Short-acting neuromuscular blockade is useful in determining background cerebral activity on CEEG otherwise partially or completely obscured by muscle artifact in patients with postanoxic myoclonus. Fully understanding background cerebral activity is important in prognostication and treatment, particularly when there are underlying EEG seizures.
A New Ranking Principle For Ordering Trapezoidal Intuitionistic Fuzzy Numbers
Authors: Velu Lakshmana Gomathi Nayagam , Selvaraj Jeevaraj , Ponnialagan Dhanasekaran
Published: February 2017

Modelling real life (industrial) problems using intuitionistic fuzzy numbers is inevitable in the present scenario due to their efficiency in solving problems and their accuracy in the results. Particularly, trapezoidal intuitionistic fuzzy numbers (TrIFNs) are widely used in describing impreciseness and incompleteness of a data. Any intuitionistic fuzzy decision-making problem requires the ranking procedure for intuitionistic fuzzy numbers. Ranking trapezoidal intuitionistic fuzzy numbers play an important role in problems involving incomplete and uncertain information. The available intuitionistic fuzzy decision-making methods cannot perform well in all types of problems, due to the partial ordering on the set of intuitionistic fuzzy numbers. In this paper, a new total ordering on the class of TrIFNs using eight different score functions, namely, imprecise score, nonvague score, incomplete score, accuracy score, spread score, nonaccuracy score, left area score, and right area score, is achieved and our proposed method is validated using illustrative examples. Significance of our proposed method with familiar existing methods is discussed.
New Records ofHyphoderma(Meruliaceae, Polyporales) for India
Authors: Sanyal Sanjeev Kumar , Devi Ritu , Dhingra Gurpaul Singh
Published: February 2017

An account of eight species of genusHyphoderma(H.clavatum,H.definitum,H.echinocystis,H.litschaueri,H.nemorale,H.subpraetermissum,H.tibia,andH.transiens) is presented, which is based on collections made from Uttarakhand state during 2009–2014. All these species are cited and fully described for the first time from India.
Comprehensive Evaluation of Anterior Corneal Change in Asphericity Calculated by the Tangential Radius of Curvature after LASIK
Authors: Ying Jinglu , Cai Jianqiu , Zhu Leru , Zha Yi
Published: February 2017

To evaluate the change in the anterior corneal asphericity (ΔQ) comprehensively calculated using the tangential radius (rt) after LASIK. Forty-two right eyes were evaluated using the Orbscan II corneal topographer. The pre- and postoperativeQ-values of the flat principal semimeridians calculated by the sagittal radius were compared to those by the tangential radius. TheQ-value of each semimeridian in the horizontal region was calculated byrt. Fourier fitting was used to model the 360-semimeridional variation ofQ-values and to fit theQ-values in the vertical region before and after surgery. There were significant differences inQ-values between the two methods before (P<0.001) and after surgery (P=0.003). A significant increase in postoperativeQ-value was detected compared to preoperativeQ-value (P<0.001) calculated byrt. The 360-semimeridional variation of theQ-values was well fitted with a third- and fourth-degree Fourier function before and after surgery. The ΔQ-value distribution presented double valley variation, with the amount of ΔQbeing lowest in the near-vertical regions and highest in the near-horizontal regions. Calculating theQ-value withrtcombined with Fourier fitting, we evaluated 360 ΔQ-values’ variation of semimeridians of the entire anterior corneal surface and then displayed true and complete anterior corneal shape after LASIK.
Impact of Desensitization on Antiviral Immunity in HLA-Sensitized Kidney Transplant Recipients
Authors: Toyoda Mieko , Shin Bong-Ha , Ge Shili , Mirocha James , Thomas David , Chu Maggie , Rodriguez Edgar , Chao Christine , Petrosyan Anna , Galera Odette A. , Vo Ashley , Choi Jua , Peng Alice , Kahwaji Joseph , Jordan Stanley C.
Published: February 2017

Viral infections represent significant morbidity and mortality factors in kidney transplant recipients, with CMV, EBV, and BKV infections being most common. Desensitization (DES) with IVIg and rituximab with/without plasma exchange followed by kidney transplantation with alemtuzumab induction increased successful transplant rates in HLA-sensitized patients but may represent an increased risk for viral infections due to severe lymphocyte depletion. Here, we report on the posttransplant viral infection status in 372 DES versus 538 non-DES patients. CMV and EBV viremia were significantly lower in DES patients, while BKV viremia was similar. This trend was observed primarily in CMV sero(−), EBV sero(+), and sero(−) patients. No patient developed PTLD. The incidence of BKAN, allograft, and patient survival was similar in both groups. These viral infections were not associated with subsequent allograft rejection which occurred within 6 months after the infection.Conclusions.The IVIg + rituximab desensitization combined with alemtuzumab induction with triple immunosuppression maintenance does not increase the risk for CMV, EBV, and BKV infections. Possible factors include, in addition to posttransplant antiviral prophylaxis and PCR monitoring, presence of memory T cells and antibodies specific to CMV and likely EBV, NK cell-mediated ADCC despite lymphocyte depletion, elimination of EBV and CMV reservoirs by rituximab and alemtuzumab, and use of IVIg with antiviral properties.
Assessment of Aerobic Exercise Adverse Effects during COPD Exacerbation Hospitalization
Authors: Knaut Caroline , Mesquita Carolina Bonfanti , Caram Laura M. O. , Ferrari Renata , Dourado Victor Zuniga , Godoy Irma de , Tanni Suzana Erico
Published: February 2017

Introduction.Aerobic exercise performed after hospital discharge for exacerbated COPD patients is already recommended to improve respiratory and skeletal muscle strength, increase tolerance to activity, and reduce the sensation of dyspnea. Previous studies have shown that anaerobic activity can clinically benefit patients hospitalized with exacerbated COPD. However, there is little information on the feasibility and safety of aerobic physical activity performed by patients with exacerbated COPD during hospitalization.Objective.To evaluate the effects of aerobic exercise on vital signs in hospitalized patients with exacerbated COPD.Patients and Methods.Eleven COPD patients (63% female, FEV1: 34.2 ± 13.9% and age: 65 ± 11 years) agreed to participate. Aerobic exercise was initiated 72 hours after admission on a treadmill; speed was obtained from the distance covered in a 6-minute walk test (6MWT). Vital signs were assessed before and after exercise.Results.During the activity systolic blood pressure increased from 125.2 ± 13.6 to 135.8 ± 15.0 mmHg (p=0.004) and respiratory rate from 20.9 ± 4.4 to 24.2 ± 4.5 rpm (p=0.008) and pulse oximetry (SpO2) decreased from 93.8 ± 2.3 to 88.5 ± 5.7% (p<0.001). Aerobic activity was considered intense, heart rate ranged from 99.2 ± 11.5 to 119.1 ± 11.1 bpm at the end of exercise (p=0.092), and patients reached on average 76% of maximum heart rate.Conclusion.Aerobic exercise conducted after 72 hours of hospitalization in patients with exacerbated COPD appears to be safe.
Comparison of the Fractional Exhaled Nitric Oxide Levels in Adolescents at Three Schools Located Three Different Distances from a Large Steel Mill
Authors: Acat Murat , Aydemir Yusuf , Yazıcı Onur , Turğut Mahmut , Çörtük Mustafa , Çakar Murat , Yaşar Zehra , Deniz Sami , Çetinkaya Erdoğan
Published: February 2017

Objectives. Exposure to ambient metals and air pollutants in urban environments has been associated with impaired lung health and inflammation in the lungs. Fractional exhaled nitric oxide (FeNO) is a reliable marker of airway inflammation. In this study, we aimed to compare the FeNO levels of three schools that have different distances from iron and steel industry zone for assessing the effects of heavy metals and air pollution on their respiratory health. Methods. Pulmonary function test and FeNO measurements were evaluated in 387 adolescents in three schools which have different distance from plant. Results. FeNO levels were significantly higher in School I (n=142; 18.89±12.3 ppb) and School II (n=131; 17.68±7.7 ppb) than School III (n=114; 4.28±3.9 ppb). Increased FeNO concentration was related to the distance of iron and steel industry zone in young adults. Conclusion. The FeNO concentrations in school children were inversely proportional to the distance from the steel mill. There are needed some studies that can evaluate the safe distance and legislation must consider these findings.
Permanent Deformation Characteristics of Coarse Grained Subgrade Soils under Train-Induced Repeated Load
Authors: Ling Xianzhang , Li Peng , Zhang Feng , Zhao Yingying , Li Yan , An Lingshi
Published: February 2017

This paper presents the results of a laboratory experiment that aimed to characterize the permanent deformation behavior of coarse grained soils. To evaluate the effects of the cyclic stress amplitude, initial mean stress, and initial stress ratio on the permanent axial deformation, six series of repeated load triaxial tests were performed. The results indicate that permanent deformation of coarse grained soils increased with increasing cyclic stress amplitude. In particular, for relative low cyclic stress levels, accumulation rate of permanent deformation decreased progressively with number of cycles and eventually reached an equilibrium state. The initial stress ratio was also found to obviously facilitate the buildup of axial deformation since it means higher deviatoric stress as the mean pressure kept constant. As the initial stress ratio was less than the slope of static failure line, the experimental results indicated that the increase of initial mean stress enhanced the capability of resisting deformation. A simplified mechanistic empirical prediction model was proposed, which predicted the permanent deformation as product of four independent functions about cyclic stress amplitude, initial mean stress, initial stress ratio, and number of load cycles. Satisfactory predictions of the permanent deformation behavior of coarse grained soils were obtained with the proposed model.
Development of a Point Pyroshock Source Simulator
Authors: Jeong Ju-won , Lim Jae hyuk , Kim Kyung-won , Lee Jung-ju
Published: February 2017

We developed a point pyroshock source simulator (PPSS) for the study on the source isolation approach (SIA) in this study. In spite of the potentiality of the SIA for avionics protection against pyroshock, it has rarely been investigated due to lack of pyroshock source simulators. To overcome such a situation, we proposed the PPSS using a mechanically excited tuned resonator simulating a release device itself. The PPSS was designed using explicit finite element analysis and Seigel’s gas gun model. To verify the proposed PPSS, the prototype was fabricated and tested. From the results, we have shown that the prototype of the PPSS simulates a near-field pyroshock and is able to evaluate the SIA.
The Draft Genome and Transcriptome of the Atlantic Horseshoe Crab,Limulus polyphemus
Authors: Simpson Stephen D. , Ramsdell Jordan S. , Watson III Winsor H. , Chabot Christopher C.
Published: February 2017

The horseshoe crab,Limulus polyphemus, exhibits robust circadian and circatidal rhythms, but little is known about the molecular mechanisms underlying those rhythms. In this study, horseshoe crabs were collected during the day and night as well as high and low tides, and their muscle and central nervous system tissues were processed for genome and transcriptome sequencing, respectively. The genome assembly resulted in7.4×105contigs with N50 of 4,736, while the transcriptome assembly resulted in9.3×104contigs and N50 of 3,497. Analysis of functional completeness by the identification of putative universal orthologs suggests that the transcriptome has three times more total expected orthologs than the genome. Interestingly, RNA-Seq analysis indicated no statistically significant changes in expression level for any circadian core or accessory gene, but there was significant cycling of several noncircadian transcripts. Overall, these assemblies provide a resource to investigate theLimulusclock systems and provide a large dataset for further exploration into the taxonomy and biology of the Atlantic horseshoe crab.
The Neuroprotective Effects of Brazilian Green Propolis on Neurodegenerative Damage in Human Neuronal SH‐SY5Y Cells
Authors: Ni Junjun , Wu Zhou , Meng Jie , Zhu Aiqin , Zhong Xin , Wu Shizheng , Nakanishi Hiroshi
Published: February 2017

Oxidative stress and synapse dysfunction are the major neurodegenerative damage correlated to cognitive impairment in Alzheimer’s disease (AD). We have found that Brazilian green propolis (propolis) improves the cognitive functions of mild cognitive impairment patients living at high altitude; however, mechanism underlying the effects of propolis is unknown. In the present study, we investigated the effects of propolis on oxidative stress, expression of brain‐derived neurotrophic factor (BDNF), and activity‐regulated cytoskeleton‐associated protein (Arc), the critical factors of synapse efficacy, using human neuroblastoma SH‐SY5Y cells. Pretreatment with propolis significantly ameliorated the hydrogen peroxide‐ (H2O2‐) induced cytotoxicity in SH‐SY5Y cells. Furthermore, propolis significantly reduced the H2O2‐generated reactive oxygen species (ROS) derived from mitochondria and 8‐oxo‐2′‐deoxyguanosine (8‐oxo‐dG, the DNA oxidative damage marker) but significantly reversed the fibrillar β‐amyloid and IL‐1β‐impaired BDNF‐induced Arc expression in SH‐SY5Y cells. Furthermore, propolis significantly upregulated BDNF mRNA expression in time‐ and dose‐dependent manners. In addition, propolis induced Arc mRNA and protein expression via phosphoinositide‐3 kinase (PI3K). These observations strongly suggest that propolis protects from the neurodegenerative damage in neurons through the properties of various antioxidants. The present study provides a potential molecular mechanism of Brazilian green propolis in prevention of cognitive impairment in AD as well as aging.
External Use of Propolis for Oral, Skin, and Genital Diseases: A Systematic Review and Meta‐Analysis
Authors: Sung Soo-Hyun , Choi Gwang-Ho , Lee Nam-Woo , Shin Byung-Cheul
Published: February 2017

Objective. The aim of this review is to provide the available evidence on the external use of propolis (EUP) for oral, skin, and genital diseases. Method. We searched twelve electronic databases for relevant studies up to June 2016. Randomized clinical trials (RCTs) were included and analysed. Results. Of the 286 articles identified, twelve potentially relevant studies met our inclusion criteria. A meta‐analysis of two studies on recurrent oral aphthae (ROA) indicated that there were no significant differences in total effective rate (TER) for pain disappearance between EUP and placebo groups (RR = 1.96, 95% CI = 0.97–3.98, and P = 0.06). In two studies on skin diseases, the combined treatment of EUP with other interventions revealed significant effects on the duration of treatment or TER. In one study on genital diseases, EUP showed significant differences in genital herpes outcome measures compared to placebo. Conclusions. Our results on the effectiveness of EUP for treating oral, skin, and genital diseases are not conclusive because of the low methodological qualities and small sample sizes. Further well‐designed randomized controlled trials, with high quality and large samples for specific disorders, must be conducted to obtain firm conclusions.
Study of the Thermal Properties of Raffia Bamboo Vinifera L. Arecaceae
Authors: Foadieng E. , Talla P. K. , Nkamgang G. B. , Fogue M.
Published: February 2017

Raffia is a kind of fast-growing palm tree, from the family of Arecaceae, encountered in marshy areas and along rivers. In this study, the “Raffia Bamboo” is the stalk of a palm, made of a fragile marrow inside a thin shell, smooth and hard to protect the latter. In our region, this material is widely used to build all the low-cost traditional houses and furniture, to make granaries storage of dry products, to build chicken coops, to make decoration. Thus, various jobs are organized around this material, with the fight against poverty. To our knowledge, information on its thermal properties is almost nonexistent. The experimental determination of the transverse thermal properties of the dry shell, the dry marrow, and the whole dry bamboo helped to find, for each, a specific heat, a thermal diffusivity, a thermal conductivity, and finally a thermal effusivity. From the analysis of results, we deduce that the thermal properties of raffia bamboo vinifera L. Arecacea make it a very good thermal insulator.
Tuning Chromosomal Instability to Optimize Tumor Fitness
Authors: Burkard Mark E. , Weaver Beth A.
Published: February 2017

Summary: Low rates of chromosomal instability (CIN) are weakly tumor promoting, whereas high rates of CIN cause cell death and tumor suppression. In this context, Sansregret and colleagues show that one mechanism to restrain excessive CIN in tumor cells and increase fitness is through mutations in the anaphase promoting complex/cyclosome. This serves to delay mitotic progression and decrease the rate of chromosome missegregation. Cancer Discov; 7(2); 134–6. ©2017 AACR.

See related article by Sansregret et al., p. 218.
Epigenomic Inactivation of RasGAPs Activates RAS Signaling in a Subset of Luminal B Breast Cancers
Authors: Sears Rosalie , Gray Joe W.
Published: February 2017

Summary: Invasion and metastasis of a subset of aggressive luminal B breast cancers is driven by the concomitant inactivation of the RasGAPs DAB2IP and RASAL2. Inactivation of both proteins increases RAS activity and drives invasion, whereas inactivation of DAB2IP specifically promotes NF-κB–mediated epithelial–mesenchymal transition. Cancer Discov; 7(2); 131–3. ©2017 AACR.

See related article by Olsen et al., p. 202.
ВЕГЕТАТИВНІ РОЗЛАДИ ПРИ ХРОНІЧНОМУ ПАНКРЕАТИТІ ТА ПОЄДНАНИХ ШЛУНКОВО-КИШКОВИХ СТАНАХ
Authors: Sabat Z. I. , Babinets L. S. , Lazarchuk T. B. , Popovych N. M.
Published: February 2017

У статті проаналізовано літературні джерела щодо ролі вегетативних дисфункцій та інших психосоматичних розладів у виникненні та перебігу панкреатиту і поєднаних шлунково-кишкових станів. Досліджується вплив відхилення балансу регуляції вегетативною нервовою системою на появу гемодинамічних, метаболічних, енергетичних порушень при вищевказаних патологічних станах.
ОСОБЛИВОСТІ ФУНКЦІОНУВАННЯ СИСТЕМИ ОХОРОНИ ЗДОРОВ’Я В УМОВАХ ДЕЦЕНТРАЛІЗАЦІЇ ТА СПІВПРАЦІ З ОБ’ЄДНАНИМИ ТЕРИТОРІАЛЬНИМИ ГРОМАДАМИ НА ПРИКЛАДІ ТЕРНОПІЛЬСЬКОЇ ОБЛАСТІ
Authors: Babinets L. S. , Borovyk I. O. , Kmita H. H.
Published: February 2017

У статті проаналізовано загальний стан забезпечення населення Тернопільської області лікувально-профілактичними закладами охорони здоров’я, висвітлено перші етапи процесу проведення реформ з децентралізації та створення об’єднаних територіальних громад області. Визначено, що найефективнішим шляхом оптимізації мережі лікувально-профілактичних закладів та ліжкового фонду зокрема є формування єдиного медичного простору, в основу якого покладена інтеграція закладів охорони здоров’я, що перебувають у власності різних територіальних громад та різних відомств.
ДИНАМІКА ПОКАЗНИКІВ АПОПТОЗУ ЛЕЙКОЦИТІВ КРОВІ У ПАЦІЄНТІВ, ХВОРИХ НА ЦУКРОВИЙ ДІАБЕТ 2 ТИПУ ТА ХРОНІЧНУ ХВОРОБУ НИРОК
Authors: Vons L. Z. , Martynyuk L. P. , Vodvud V. K.
Published: February 2017

Метою нашого дослідження було визначити динаміку показників апоптозу лейкоцитів крові у хворих на цукровий діабет (ЦД) 2 типу та хронічну хворобу нирок (ХХН) І–V стадії.Під нашим спостереженням знаходилась група із 98 пацієнтів, із них з ХХН І–V стадія та ЦД 2-го типу – 73 хворих та 25 досліджуваних контрольної групи.
МОРФОЛОГІЧНІ ЗМІНИ В ПЕЧІНЦІ СТАТЕВОЗРІЛИХ САМОК БІЛИХ ЩУРІВ ЗА УМОВ ЕКСПЕРИМЕНТАЛЬНОГО ХРОНІЧНОГО ТОКСИЧНОГО ГЕПАТИТУ І ЇХ ВПЛИВ НА РЕПРОДУКЦІЮ
Authors: Lymar L. Ye. , Lymar N. A.
Published: February 2017

Погіршення демографічної ситуації в Україні впродовж минулих десятиліть продовжується. Тому збереження репродуктивного здоров'я нації є пріоритетним завданням охорони здоров'я та розвитку медичної науки нашої країни. Вагомою причиною негативного демографічного показника є високий рівень безпліддя, зокрема ендокринного ґенезу, який складає 15–25 % [1]. Порушення функції репродуктивної системи є актуальною проблемою, оскільки призводить не лише до втрати працездатності, а й до зниження репродукції людини. Значна роль у виникненні ендокринного безпліддя належить не лише генетично детермінованим змінам в організмі жінки, але й супутній патології. У жінок часто спостерігається поєднання порушень функції репродуктивної системи з хронічними гепатитами різного ґенезу. Це спонукало нас до виконання експериментальної роботи для детального вивчення та аналізу вказаної проблеми. В доступних для огляду літературних джерелах ми не знайшли подібних експериментальних досліджень щодо моделювання патологічного процесу та вивчення структурних змін у печінці та органах репродуктивної системи при хронічних гепатитах.Ми змоделювали хронічний токсичний гепатит у статевозрілих самок білих щурів, вивчали результати клінічних, гістологічних досліджень, показники імунного та гормонального статусу, функції печінки у піддослідних тварин, а також їх репродуктивну функцію за умов експериментального токсичного гепатиту. Обстежено 40 статевозрілих самок білих щурів зі змодельованим хронічним токсичним гепатитом (ХТГ). Вивчено клінічні прояви захворювання, стан функції печінки, гормональний статус, морфологічні зміни в печінці цих тварин та їх репродуктивну функцію.
КЛІНІКО-ПСИХОЛОГІЧНІ ФЕНОМЕНИ У ПАЦІЄНТІВ ОНКОЛОГІЧНОЇ ПРАКТИКИ НА РІЗНИХ ЕТАПАХ ЛІКУВАЛЬНОГО ПРОЦЕСУ
Authors: Mukharovska I. R.
Published: February 2017

У роботі проводилося вивчення провідних клініко-психологічних симптомів на етапах лікувального процесу.
СТАН СЕКСУАЛЬНОЇ ВЗАЄМОДІЇ В РОДИНАХ ЖІНОК З ПОРУШЕННЯМ ЗДОРОВ’Я СІМ’Ї ТА РІЗНИМ АДДИКТИВНИМ СТАТУСОМ
Authors: Savina M. V.
Published: February 2017

З використанням клініко-психологічного та психодіагностичного методів обстежено 371 подружню пару, які звернулися за допомогою з приводу порушення сімейних стосунків, серед яких в 321 родині мали місце прояви аддиктивної поведінки (АП) у жінок (ДГ1), а у інших 50 сімей – нормативні показники АП у жінки (ДГ2). В якості групи порівняння (ГП) обстежено 50 умовно гармонійних ПП. На відміну від жінок ГП, які характеризувались відсутністю ознак порушення сексуальної взаємодії, серед осіб ДГ1 і ДГ2 встановлені клінічно окреслені порушення сексуального здоров’я, що мали більшу представленість в і вираженість у подружжів ДГ2, в яких у дружин не було проявів АП. В ґенезі порушення сексуальної взаємодії, для родин, в яких у жінки встановлена АП, стрижневим виявилося ураження психологічного його компонента у обох з подружжя, а наявність проявів АП у дружини – лише патопластичним фактором (p˂0,05). В механізмах розвитку порушення сексуальної взаємодії у ДГ2, стрижневими були ураження психологічного та соціально-психологічного компонентів, інші мали патопластичний вплив на формування деформації сексуальної взаємодії (p˂0,05). Вираженість деструктивного впливу порушення психологічного компонента сексуальної взаємодії, як стрижневого ураження, мало більш виражений характер у подружжів ДГ2, ніж у ДГ1 (p˂0,05). Можна припустити, що АП, виявлена у жінок з помірною вираженістю порушення сексуальної взаємодії, ставала способом нівеляції психоемоційного напруження, що виникало внаслідок неотримання від родини відчуття психологічного притулку та підтримки, та знижувала рівень його вираженості. На відміну від них, жінки з нормативним адиктивним статусом, наявне негативне психоемоційне фрустраційне тло реалізовували в рамках сім'ї, створюючи тим самим високий рівень подружньої конфліктності і деформації сексуальної взаємодії. Отримані дані були покладені нами в основу при розробці системи психологічної корекції та психопрофілактичної підтримки здоровʼя сімʼї за наявності АП у жінок.
ЯДЕРНО-ЦИТОПЛАЗМАТИЧНІ ВІДНОШЕННЯ У КАРДІОМІОЦИТАХ ТА ЕНДОТЕЛІОЦИТАХ ПЕРЕДСЕРДЬ ЛЕГЕНЕВOГО СЕРЦЯ
Authors: Slabyі O. B.
Published: February 2017

Досліджені ядерно-цитоплазматичні відношення у кардіоміоцитах та ендотеліоцитах передсердь легеневого серця. Встановлено, що співвідношення між ядром та цитоплазмою вказаних клітин пердсердь легеневого серця суттєво змінювалися, що свідчило про порушення клітинного структурного гомеостазу. Найвираженішими зміни ядерно-цитоплазматичних відношень виявлені у правому передсерді декомпенсованого легеневого серця.
ДИНАМІЧНИЙ МАРКЕТИНГОВИЙ АНАЛІЗ ВІТЧИЗНЯНОГО РИНКУ ПРОТИВІРУСНИХ ЛІКАРСЬКИХ ЗАСОБІВ ГРУП J05AB01, J05AХ05, J05AХ10
Authors: Fedyak I. O. , Ivanyulyk I. I.
Published: February 2017

У статті висвітлені результати маркетингового аналізу груп противірусних препаратів, які рекомендовано для лікування хворих на дитячі вірусні інфекції (вітряну віспу, кір, краснуху). Упродовж 42 місяців - з 01.01.2013 до 01.07.2016 р. - був проведений щомісячний моніторинг їх асортименту, середніх оптово-відпускних цін, коефіцієнтів ліквідності та платоспроможності населення. Встановлено, що противірусні препарати груп ацикловіру У05ДВ01), інозинпранобексу^05ДХ05) та інших противірусних У05ДХ10: амізону, протефлазіду, флавозіду) є достатньо представлені на вітчизняному фармацевтичному ринку, доступність яких зросла наприкінці моніторингу. Найнижчою їх оптово-відпускна ціна була у січні 2013 р., а найвищою - у жовтні - листопаді 2014 та 2015 рр., березні - квітні 2016 р. Не спостерігається прямої залежності між динамікою оптової ціни препаратів і динамікою курсу гривні відносно до долара, оскільки стрибки підйому оптово-відпускних цін випереджували ріст долара на 1-3 місяці для одних ліків, а для інших, навпаки, на тлі загального росту відбулося різке зниження ціни. Тому на даний час цей сегмент оптового фармацевтичного ринку лікарських засобів не можна вважати достатньо прогнозованим.
OBSERVATION OF MEDICINES FOR THE TREATMENT OF DIAPER DERMATITIS ON THE PHARMACEUTICAL MARKET OF UKRAINE
Authors: Hlushchenko O. M. , Butkevych T. A. , Khomenko R. M.
Published: February 2017

Пелюшковий дерматит зустрічається у кожної другої дитини першого року життя. Основними причинами його розвитку вважаються порушення бар’єрної функції шкіри та неправильний догляд за нею. У роботі проаналізовані дані літературних джерел щодо причин виникнення, симптоматики, профілактики та лікування пелюшкового дерматиту, досліджений асортимент лікарських засобів на фармацевтичному ринку України, що використовуються для його лікування.
ЕЛЕМЕНТНИЙ СКЛАД БРУНЬОК БАЛЬЗАМІЧНИХ ТОПОЛЬ, ЯКІ КУЛЬТИВУЮТЬ В УКРАЇНІ
Authors: Rudnik A. M.
Published: February 2017

Методом атомно-емісійної спектрографії у бруньках п’яти видів бальзамічних тополь, які культивують в Україні, визначено вміст 19 елементів. В бруньках усіх видів за вмістом переважають К (925 - 1190 мг/100г), Са (530 - 655 мг/100г) та Мд (200 - 245 мг/100г). Найбільший вміст практично усіх елементів визначено у бруньках тополі волосистоплідної.
СУЧАСНИЙ СТАН СТВОРЕННЯ, ВИРОБНИЦТВА ТА ДОСЛІДЖЕННЯ ТАБЛЕТОВАНИХ ЛІКАРСЬКИХ ПРЕПАРАТІВ Повідомлення 25. Осмотичні системи вивільнення та доставки лікарських речовин: характеристика імплантаційних мініосмотичних, оральних та спеціальних типів осмотичних систем, їх застосування
Authors: Demchuk M. B. , Chubka M. B. , Vronska L. V. , Hroshovyi T. A.
Published: February 2017

Проведено огляд літературних джерел щодо характеристик та можливостей застосування імплантаційних мініосмотичних, оральних та спеціальних типів осмотичних систем вивільнення та доставки лікарських речовин, наведено приклади осмотичних систем, які зареєстровані на світовому ринку.
ОГЛЯД НАУКОВИХ ДОСЛІДЖЕНЬ З МЕТОЮ ОДЕРЖАННЯ НОВИХ ФІТОПРЕПАРАТІВ НА ОСНОВІ ГЕРАНІ СИБІРСЬКОЇ
Authors: Hordiіenko O. I. , Benzel I. L. , Нroshovyi T. A.
Published: February 2017

В огляді літератури узагальнено дані про ботанічну характеристику, розповсюдження, хімічний склад і застосування герані сибірської.
Are the Central Andes Mountains a Warming Hot Spot?
Authors: Russell Alexandria M. , Gnanadesikan Anand , Zaitchik Benjamin
Published: February 2017

Global climate model simulations project that the tropical Andes Mountains of South America, which are particularly vulnerable to climate change because of a reliance on snow and glacial melt for freshwater resources, will experience enhanced warming in the near future, with both higher rates of warming at higher elevations within the mountain range itself and localized enhancement of warming exceeding surrounding areas of the globe. Yet recent surface temperature changes in the tropical Andes do not show evidence for either elevation-dependent warming or regional enhancement of warming on average. However, it remains a possibility that the expected warming trends in this region have begun to manifest in other ways (e.g., in the free atmosphere or at intermediate mountain elevations). This paper proposes evidence from several reanalysis products that there has indeed been a regional enhancement of midtropospheric warming around the central Andes over the past few decades that makes this region stand out as a hot spot within the broader pantropics. This trend is generally not reproduced by historical AMIP climate model simulations, which suggests that the mechanisms through which the atmosphere is warming over the central Andes are not adequately captured by climate models. Possible explanations for localized enhancement of warming in this region are considered. On the other hand, reanalysis products do not consistently exhibit enhanced warming at intermediate mountain elevations in the central Andes as evidenced by the generally moderate rates of change in the freezing-level height, except perhaps in the highest-resolution reanalysis product.
Impact of the Summer Monsoon Westerlies on the South China Sea Tropical Cyclone Genesis in May
Authors: Chen Tsing-Chang , Tsay Jenq-Dar , Matsumoto Jun , Alpert Jordan
Published: February 2017

After the onset of the Southeast Asian summer monsoon in mid-May, the South China Sea (SCS) trough is deepened by the intensified monsoon westerlies to facilitate the development of a synoptic cyclonic shear flow. This shear flow forms an environment favorable for the SCS tropical storm (TS)/typhoon (TY) genesis triggered by the surge of this monsoon circulation. This genesis mechanism has not been well documented. Seventeen named SCS TS/TY geneses in May over 1979–2016 occurred under the following environmental conditions/processes: 1) with its maximum located south of 15°N, the intensified monsoon westerlies are extended eastward beyond 120°E, 2) the synoptic SCS cyclonic shear flow is developed by the tropical easterlies fed by a northeast Asian cold surge (or a North Pacific cold-air outbreak) and the intensified monsoon westerlies, and 3) SCS TS/TY genesis is triggered by the surge of monsoon flow. The accuracy of the monthly mean forecasts is limited. However, it is found that SCS TS/TY genesis only occurs after the existence of persistent, strong, monsoon westerlies lasting for at least 5 days. Forecasts from the National Centers for Environmental Prediction Global Forecast System (2004–16) and the Global Ensemble Forecast System (1985–2003) cover these 15 SCS TS/TY geneses. The requirements for SCS TS/TY genesis in May described above are met by the 5-day-mean Southeast Asian summer monsoon circulation. Based on a statistical analysis of 5-day forecasts for these TS/TY geneses, a four-step forecast advisory is introduced. The forecasts for SCS TS/TY genesis can be made 3 days prior to occurrence.
Partisanship, Tax Policy, and Corporate Profit-Shifting in a Globalized World Economy
Authors: Shin Mi Jeong
Published: February 2017

Political science scholarship has found mixed evidence on the impact of partisanship on the taxation of firms. In this article, I show that although left-leaning governments set tax rates at higher levels than right-leaning governments, the difference in the effective tax rates paid by firms is much less dramatic between left and right governments. I argue that left-leaning governments maintain high tax rates, a visible policy their constituency supports, while allowing firms to transfer profits abroad to minimize their tax burden (transfer pricing). Constituency costs hinder them from cutting tax rates to avoid backlash from voters, but they impose fewer restrictions on profit-shifting to attract investment by multinational firms for economic growth. Data covering 19 advanced economies between 2006 and 2009 support my theoretical expectation. My analyses suggest that the effect of government partisanship on corporate tax policy can be ambiguous when political parties consider various policy tools.