bluuebunny/crossref_metadata_2025 huggingface dataset:
By the numbers: ratings and utilization of behavioral health mobile applications
Authors: Carlo Andrew D. , Hosseini Ghomi Reza , Renn Brenna N. , Areán Patricia A.
Published: June 2019

Although >10,000 behavioral health applications (“apps”) are currently available on the Apple and Google Play marketplaces, they have been minimally evaluated or regulated and little is known about “real world” usage patterns. This investigation combined data from online behavioral health app rating frameworks and a mobile health market research firm to identify the most downloaded apps as well as determine rating and ranking concordance between frameworks. Findings demonstrated that the most commonly downloaded apps focus on relaxation, mindfulness, and meditation skills and that they often have notably discordant reviews across rating frameworks. Our results suggest that there is a growing need for: (1) standardized behavioral health app quality and effectiveness measures, (2) up-to-date behavioral health app guidance for clinicians and consumers, and (3) evidence-based apps that incorporate revealed consumer preferences.
Promoter-dependent nuclear RNA degradation ensures cell cycle-specific gene expression
Authors: Catala Mathieu , Abou Elela Sherif
Published: June 2019

Cell cycle progression depends on phase-specific gene expression. Here we show that the nuclear RNA degradation machinery plays a lead role in promoting cell cycle-dependent gene expression by triggering promoter-dependent co-transcriptional RNA degradation. Single molecule quantification of RNA abundance in different phases of the cell cycle indicates that relative curtailment of gene expression in certain phases is attained even when transcription is not completely inhibited. When nuclear ribonucleases are deleted, transcription of the Saccharomyces cerevisiae G1-specific axial budding gene AXL2 is detected throughout the cell cycle and its phase-specific expression is lost. Promoter replacement abolished cell cycle-dependent RNA degradation and rendered the RNA insensitive to the deletion of nuclear ribonucleases. Together the data reveal a model of gene regulation whereby RNA abundance is controlled by promoter-dependent induction of RNA degradation.
Functional synthetic probes for selective targeting and multi-analyte detection and imaging
Authors: Yue Yongkang , Huo Fangjun , Cheng Fangqin , Zhu Xijing , Mafireyi Tendai , Strongin Robert M. , Yin Caixia
Published: June 2019

Probes with multiple interaction sites or with single sites promoting tandem reactions target challenging analytes and enable the visualization of in vivo interactions.
A cobalt-doped iron oxide nanozyme as a highly active peroxidase for renal tumor catalytic therapy
Authors: Wang Yixuan , Li Hongjun , Guo Lihua , Jiang Qi , Liu Feng
Published: June 2019

Cobalt dopant in Fe3O4 nanozymes improved their binding affinity to H2O2 and enhanced the tumor catalytic therapy efficacy.
Modified silver nanoparticles-enhanced single drop microextraction of tartrazine in food samples coupled with diffuse reflectance Fourier transform infrared spectroscopic analysis
Authors: Tiwari Swapnil , Deb Manas Kanti
Published: June 2019

The use of tartrazine as an ingredient in foodstuffs is a general practice; tartrazine is added for reasons such as enhancing the color of food and making it attractive and appetizing.
A label-free and enzyme-free aptasensor for visual Cd2+detection based on split DNAzyme fragments
Authors: Zhou Danhua , Wu Wei , Li Qiong , Pan Jiafeng , Chen Junhua
Published: June 2019

A label-free and enzyme-free three-way G-quadruplex junction sensing system was developed for Cd2+detection with a naked-eye readout.
Indocyanine green binds to DOTAP liposomes for enhanced optical properties and tumor photoablation
Authors: Miranda Dyego , Wan Chao , Kilian Hailey I. , Mabrouk Moustafa T. , Zhou Yuhan , Jin Honglin , Lovell Jonathan F.
Published: June 2019

Simple mixing of ICG with DOTAP liposomes results in full dye binding to the liposomes and enhanced ICG optical properties.
Tweaking the proton transfer triggered proton transfer of 3,5-bis(2-hydroxyphenyl)-1H-1,2,4-triazole
Authors: Das Minati , Sahu Saugata , Krishnamoorthy G.
Published: June 2019

Proton transfer triggered proton transfer (PTTPT) of the molecule is completely altered by dimethylformamide and the proton transfer paths are changed. The process can be reversed by silver particle.
Heterostructural design of I-deficient BiOI for photocatalytic decoloration and catalytic CO2 conversion
Authors: Hu Chechia , Huang Hui-Xin , Lin Yi-Feng , Tung Kuo-Lun , Chen Tzu-Hsin , Lo Lin
Published: June 2019

I− vacancies in BiOI play a major role in governing the photocatalysis and catalysis.
Preparation of hierarchical catalysts with the simultaneous generation of microporous zeolite using a template and large mesoporous silica by gel skeletal reinforcement and their reactivity in the catalytic cracking of n-dodecane
Authors: Ishihara Atsushi , Mori Kouki , Mori Kazuya , Hashimoto Tadanori , Nasu Hiroyuki
Published: June 2019

Zeolite-containing hierarchical mesoporous catalysts prepared using gel skeletal reinforcement exhibited the superior activity and selectivity in n-dodecane catalytic cracking.
Constructing a fragmentary g-C3N4 framework with rich nitrogen defects as a highly efficient metal-free catalyst for acetylene hydrochlorination
Authors: Qiao Xianliang , Zhou Zhiqiang , Liu Xinyu , Zhao Chaoyue , Guan Qingxin , Li Wei
Published: June 2019

Fragmentary g-C3N4 was prepared using a melamine formaldehyde resin precursor, which exhibited an activity 30 times higher than pure g-C3N4 in acetylene hydrochlorination.
A ruthenium bisoxazoline complex as a photoredox catalyst for nitro compound reduction under visible light
Authors: Jia Wei-Guo , Cheng Ming-Xia , Gao Li-Li , Tan Siu Min , Wang Chao , Liu Xiaogang , Lee Richmond
Published: June 2019

A novel ruthenium(ii) complex containing bisoxazoline and bipyridine ligands has been synthesized and characterized, which shows high catalytic activities for nitro compounds in the presence of sodium borohydride and visible light.
Phase coexistence induced strong piezoelectricity in K0.5Na0.5NbO3-based lead-free ceramics
Authors: Yang Yang , Wang Hua , Li Yao , Zheng Qiaoji , Liao Jie , Jie Wenjing , Lin Dunmin
Published: June 2019

For perovskite ceramics, the ferroelectric phase boundary plays an important role in improving the piezoelectricity of the materials.
Silver halide complexes of a borane/bis(phosphine) ligand
Authors: Cao Yihan , Shih Wei-Chun , Bhuvanesh Nattamai , Ozerov Oleg V.
Published: June 2019

Silver halide complexes of a borane/bis(phosphine) ligand have been prepared and characterized.
Aminofluoroalkoxide amido and boryloxo lead(ii) complexes
Authors: Someşan Adrian-Alexandru , Roisnel Thierry , Dorcet Vincent , Silvestru Cristian , Sarazin Yann
Published: June 2019

A readily available aminofluoroalcohol enables the high-yield synthesis of a three-coordinate heteroleptic lead(ii) amido complex, which in turn generates a rare case of stable boryloxide lead(ii) species upon treatment with a borinic acid.
Acute toxicity evolution during ozonation of mono-chlorophenols and initial identification of highly toxic intermediates
Authors: Ma Dehua , Wei Jianjian , Zhang Hongbo , Zhou Yukun , Shen Jinyou , Wang Lianjun , Zhang Peng
Published: June 2019

Acute toxicity changes during ozonation of 2-chlorophenol (2-CP), 3-chlorophenol (3-CP) and 4-chlorophenol (4-CP) under various conditions were studied using the luminescence inhibition test.
Editorial Perspectives: innovation needs for the water sector in India to achieve sustainable development goals
Authors: Philip Ligy , Bhallamudi S. Murty
Published: June 2019

Ligy Philip and S. Murty Bhallamudi provide an ‘Editorial Perspective’ on the need for innovation in India's water sector.
Synthesis of amides from acid chlorides and amines in the bio-based solvent Cyrene™
Authors: Bousfield Thomas W. , Pearce Katharine P. R. , Nyamini Simbarashe B. , Angelis-Dimakis Athanasios , Camp Jason E.
Published: June 2019

Cyrene™ as a bio-alternative dipolar aprotic solvent: a waste minimizing and molar efficient protocol for the synthesis of amides from acid chlorides and primary amines in the bio-available solvent Cyrene™ is disclosed.
Li3Ba4Sc3(BO3)4(B2O5)2: featuring the coexistence of isolated BO3and B2O5units
Authors: Meng Xianghe , Xia Mingjun , Li Rukang
Published: June 2019

A new mixed alkali/alkaline earth scandium borate Li3Ba4Sc3(BO3)4(B2O5)2with isolated and almost co-planar BO3and B2O5groups is reported.
Interfacial N–Cu–S coordination mode of CuSCN/C3N4 with enhanced electrocatalytic activity for hydrogen evolution
Authors: Zhao Ziming , Yang Haidong , Zhu Yan , Luo Sha , Ma Jiantai
Published: June 2019

Due to the electron penetration arising from the finely tuned interfacial N–Cu–S coordination mode, CuSCN/C3N4 exhibits remarkable activity for hydrogen evolution.
Ratio fluorescence analysis of T4 polynucleotide kinase activity based on the formation of a graphene quantum dot–copper nanocluster nanohybrid
Authors: Wang Mengke , Kong Deshuai , Su Dandan , Liu Yang , Su Xingguang
Published: June 2019

A ratio fluorescence strategy was proposed for T4 PNK activity analysis based on the formation of a dual-emitting GQD–CuNC nanohybrid.
A Pt-free graphenaceous composite as an electro-catalyst for efficient oxygen reduction reaction
Authors: Sravani Bathinapatla , Maseed H. , Y. Chandrasekhar , Y. Veera Manohara Reddy , V. V. S. S. Srikanth , Madhavi G. , L. Subramanyam Sarma
Published: June 2019

The MgO decorated multi-layered graphene oxide (MLGO) catalyst exhibit an efficient oxygen reduction reaction capability with high activity and durability.
Dual wavelength lasing of InGaN/GaN axial-heterostructure nanorod lasers
Authors: Chun So Yeon , Yoo Gang Yeol , Jeong Seonghyun , Park Seung Min , Eo Yun Jae , Kim Woong , Do Young Rag , Song Jae Kyu
Published: June 2019

Dual wavelength lasing is achieved in InGaN/GaN axial-heterostructure nanorods by optical confinement effects.
Experimental study on the treatment of acid mine drainage by modified corncob fixed SRB sludge particles
Authors: Dong Yan-Rong , Di Jun-Zhen , Wang Ming-Xin , Ren Ya-Dong
Published: June 2019

A cost-effective system for acid mine drainage removal was developed with the key role of alkaline H2O2 modified corncob and sulfate reducing bacteria.
Facile molten salt synthesis of Cs–MnO2hollow microflowers for supercapacitor applications
Authors: Chomkhuntod Praeploy , Jiamprasertboon Arreerat , Waehayee Anurak , Butburee Teera , Chanlek Narong , Yong Nararat , Siritanon Theeranun
Published: June 2019

Hollow microflowers of Cs intercalated MnO2binessite are prepared by a facile molten salt method and tested for supercapacitor electrodes.
Identification of graphene oxide and its structural features in solvents by optical microscopy
Authors: Xu Huailiang , Qi Zhikai , Jin Hongchang , Wang Jinxi , Qu Yan , Zhu Yanwu , Ji Hengxing
Published: June 2019

The dispersion state of graphene oxide (GO) on the microscale in solvent is a dominating factor in determining the physical properties of GO based composites.
Few-walled carbon nanotube-enhanced activated carbon supercapacitor performance in organic electrolyte at 4 V
Authors: Li Jie , Xu Zhou
Published: June 2019

The addition of 1 wt% few-walled carbon nanotubes increases the energy density of an activated carbon-based supercapacitor at 4 V.
Synthesis and biological evaluation of 4-(1H-1,2,4-triazol-1-yl)benzoic acid hybrids as anticancer agents
Authors: Abuelizz Hatem A. , Awad Hanem M. , Marzouk Mohamed , Nasr Fahd A. , Alqahtani Ali S. , Bakheit Ahmed H. , Naglah Ahmed M. , Al-Salahi Rashad
Published: June 2019

A series of 4-(1H-1,2,4-triazol-1-yl)benzoic acid hybrids (1–17) was successfully synthesized and their structures were established by NMR and MS analysis. Their anticancer activity against HCT-116, MCF-7 and normal human RPE-1 cells were examined.
Separating graphene quantum dots by lateral size through gel column chromatography
Authors: Wu Wentian , Cao Jiamin , Zhong Min , Wu Haixia , Zhang Fangwei , Zhang Jingyan , Guo Shouwu
Published: June 2019

GQDs prepared through a photo-Fenton reaction were separated into eight groups with different sizes and fluorescent colors via gel column chromatography.
Strain engineering of optical activity in phosphorene
Authors: Khoa Doan Quoc , Davoudiniya Masoumeh , Hoi Bui Dinh , Yarmohammadi Mohsen
Published: June 2019

This paper is devoted to a detailed analysis of strain effects on the optical activity of phosphorene ranging from low-optical-field to high-optical-field.
Copper-catalysed enantioselective intramolecular etherification of propargylic esters: synthetic approach to chiral isochromans
Authors: Liu Shiyao , Nakajima Kazunari , Nishibayashi Yoshiaki
Published: June 2019

The first example for direct synthesis of chiral terminal alkynyl isochromans.
Mechanochemical and slow-chemistry radical transformations: a case of diorganozinc compounds and TEMPO
Authors: Budny-Godlewski Krzysztof , Justyniak Iwona , Leszczyński Michał K. , Lewiński Janusz
Published: June 2019

The subtle nature of reactivity of the free stable nitroxyl radical TEMPO towards tBu2Zn and Ph2Zn was explored in an uncommon comparison of wet, mechanochemical and slow-chemistry reactions.
An unusual [4 + 2] fusion strategy to forge meso-N/O-heteroarene-fused (quinoidal) porphyrins with intense near-infrared Q-bands
Authors: Li Chengming , Zhu Lei , Liang Wenbo , Su Rongchuan , Yin Jiangliang , Hu Yanmei , Lan Yu , Wu Di , You Jingsong
Published: June 2019

Divergent synthesis of meso-N/O-heteroarene-fused (quinoidal) porphyrins was established via rhodium-catalyzed β-C–H activation/annulation of quinoidal porphyrins with alkynes.
Highly flexible and self-adaptive dry adhesive end-effectors for precision robotics
Authors: Lee Sung Ho , Hwang Insol , Kang Bong Su , Jeong Hoon Eui , Kwak Moon Kyu
Published: June 2019

For wide application of dry adhesives, we have realized the improvement of adhesion performance on inclined target substrate through structural design in macroscale. The improved dry adhesives exhibit stable properties in inclined targets.
Viscoelastic mapping of cells based on fast force volume and PeakForce Tapping
Authors: Efremov Yu. M. , Shpichka A. I. , Kotova S. L. , Timashev P. S.
Published: June 2019

An approach for the viscoelastic mapping of cells was developed here based on fast AFM mapping techniques and rigorous viscoelastic analysis.
Rheological behaviour and adsorption phenomenon of a polymer–particle composite based on hydrolysed polyacrylamide/functionalized poly(styrene-acrylic acid) microspheres
Authors: Lebouachera Seif El Islam , Pessoni Laurence , Ghriga Mohammed Abdelfetah , Andreu Nathalie , Chemini Rachida , Grassl Bruno , Reynaud Stéphanie
Published: June 2019

The properties in aqueous solution of polymer–particle composites (PPC) depend on the size and the concentration of both the particles and the polymers as well as the interactions between them.
A porous superhydrophobic surface with active air plastron control for drag reduction and fluid impalement resistance
Authors: Li Zhe , Marlena Jennifer , Pranantyo Dicky , Nguyen Ba Loc , Yap Choon Hwai
Published: June 2019

Robustly sustaining the air plastron by active air pressure control through a porous superhydrophobic surface for high liquid impalement resistance.
An air-stable electrochromic conjugated microporous polymer as an emerging electrode material for hybrid energy storage systems
Authors: Dai Yuyu , Li Weijun , Chen Zhangxin , Zhu Xiaogang , Liu Junlei , Zhao Ruiyang , Wright Dominic S. , Noori Abolhassan , Mousavi Mir F. , Zhang Cheng
Published: June 2019

An air-stable oxidation state is observed in an electrochromic triphenylamine–triazine polymer energy storage system after the removal of the applied potential.
Covalent organic framework-supported Fe–TiO2 nanoparticles as ambient-light-active photocatalysts
Authors: Zhang Yumin , Hu Yiming , Zhao Jianhong , Park Eunsol , Jin Yinghua , Liu Qingju , Zhang Wei
Published: June 2019

COF-supported ultrafine crystalline Fe–TiO2 nanoparticles were prepared, which show ambient light photocatalytic activity with high efficiency, stability, and recyclability.
Bifunctional π-conjugated ligand assisted stable and efficient perovskite solar cell fabrication via interfacial stitching
Authors: Wei Feijie , Jiao Bo , Dong Hua , Xu Jie , Lei Ting , Zhang Junjie , Yu Yue , Ma Lin , Wang Dongdong , Chen Jinbo , Hou Xun , Wu Zhaoxin
Published: June 2019

Ligand-assisted interface engineering has been considered as a promising strategy to improve the performance and stability of perovskite solar cells (PSCs) simultaneously.
A novel strategy for the synthesis of highly stable ternary SiOx composites for Li-ion-battery anodes
Authors: Guo Xiaotian , Zhang Yi-Zhou , Zhang Fan , Li Qing , Anjum Dalaver H. , Liang Hanfeng , Liu Yong , Liu Chun-sen , Alshareef Husam N. , Pang Huan
Published: June 2019

A facile method is used to prepare a series of high-performance Ni/SiOx/nitrogen-doped carbon ternary anodes for lithium-ion batteries.
Recent progress in piezoelectric thin film fabrication via the solvothermal process
Authors: Li Lijie , Miao Lei , Zhang Zhen , Pu Xiaohua , Feng Qi , Yanagisawa Kazumichi , Fan Yong , Fan Mingjin , Wen Puhong , Hu Dengwei
Published: June 2019

The reaction conditions are regulated to realize the preparation of a high piezoelectric thin film via a solvothermal process.
Pt–Cu based nanocrystals as promising catalysts for various electrocatalytic reactions
Authors: Chaudhari Nitin K. , Hong Yongju , Kim Byeongyoon , Choi Sang-Il , Lee Kwangyeol
Published: June 2019

This review addresses recent developments in Pt–Cu based catalysts toward various energy conversion electrocatalytic applications such as the HER, ORR, MOR, EGOR and FAOR.
A new strategy for the controllable growth of MOF@PBA architectures
Authors: Xiao Xiao , Zhang Guangxun , Xu Yuxia , Zhang Hualin , Guo Xiaotian , Liu Yong , Pang Huan
Published: June 2019

Multilevel nanostructures can expose more active sites and promote the charge transfer process, and different composite materials can promote the synergistic effect.
Diversities of stoichiometry and electrical conductivity in sodium sulfides
Authors: Wan Biao , Xu Shishuai , Yuan Xiaohong , Tang Hu , Huang Dajian , Zhou Wenju , Wu Lailei , Zhang Jingwu , Gou Huiyang
Published: June 2019

Diverse sodium sulfides revealed in Na–S systems, including Na2S2 (Pbam), Na2S3, and metallic Na5S3 and Na3S (1-D electride).
Vaginal delivery of mucus-penetrating organic nanoparticles for photothermal therapy against cervical intraepithelial neoplasia in mice
Authors: Wang Xue , Fu Li , Lin Wenhai , Zhang Wei , Pei Qing , Zheng Xiaohua , Liu Shi , Zhang Tao , Xie Zhigang
Published: June 2019

Photosensitizer-based photothermal therapy (PTT) may be a good choice for the treatment of severe cervical intraepithelial neoplasia (CIN) compared with conventional thermal ablation.
Protection against a wide UV wavelength range by Bragg reflection from polycrystalline colloidal photonic crystals
Authors: Kanai Toshimitsu , Nakashima Shinoka , Oki Tomomi
Published: June 2019

Polycrystalline colloidal crystals can block ultraviolet light of 290–400 nm, regardless of the incident angle, while maintaining transparency in the visible light region.
A SERS-based immunoassay for the detection of α-fetoprotein using AuNS@Ag@SiO2core–shell nanostars
Authors: Zhao Jing , Wu Chen , Zhai Lipeng , Shi Xiaofeng , Li Xin , Weng Guojun , Zhu Jian , Li Jianjun , Zhao Jun-Wu
Published: June 2019

A surface-enhanced Raman scattering (SERS)-based sandwich type immunoassay was developed for the detection of α-fetoprotein (AFP) with high sensitivity, reproducibility and selectivity.
Structural dependence of the microwave dielectric properties of Cr3+-substituted ZnGa2O4spinel ceramics: crystal distortion and vibration mode studies
Authors: Lu Xiaochi , Du Zehui , Quan Bin , Bian Wenjie , Zhu Haikui , Zhang Qitu
Published: June 2019

Establishment of a correlation between the crystal structure (octahedral distortion and short range ordering) and microwave dielectric performance of spinel structured Cr-ZGO.
One-step preparation of silica microspheres with super-stable ultralong room temperature phosphorescence
Authors: Tang Guoqiang , Zhang Kai , Feng Tanglue , Tao Songyuan , Han Mei , Li Rui , Wang Congcong , Wang Yao , Yang Bai
Published: June 2019

Carbonized polymer dots embedded in SiO2 microspheres with super-stable ultralong room temperature phosphorescence were prepared via a one-step strategy.
High oxide ion conductivity in layer-structured Bi4Ti3O12-based ferroelectric ceramics
Authors: Long Changbai , Ren Wei , Li Yiwen , Liu Laijun , Xia Yuanhua , Fan Huiqing
Published: June 2019

B0.97T0.73Mg0.02shows high oxide ion conductivity, which is comparable to that of other leading solid oxide electrolyte materials.
High sensitivity and wide sensing range of stretchable sensors with conductive microsphere array structures
Authors: Zheng Yan , Jin Qi , Chen Wanyi , Sun Yi , Wang Zhaoqun
Published: June 2019

The bridging effect of the unique binary structure simultaneously increases the sensitivity and operating range of a stretchable sensor.
The association between RANK, RANKL and OPG gene polymorphisms and the risk of rheumatoid arthritis: a case-controlled study and meta-analysis
Authors: Yang Haoyu , Liu Weixi , Zhou Xindie , Rui Huan , Zhang Hui , Liu Ruiping
Published: June 2019

The receptor activator of nuclear factor-κB (RANK) and the osteoprotegerin (OPG) cascade system have been reported to be essential in osteoclastogenesis. In recent years, several studies have investigated the association between polymorphisms of RANK, its ligand RANKL and OPG genes and the risk of rheumatoid arthritis (RA) in different populations. However, the results arising from these studies were conflicting. To determine the association between RANK, RANKL and OPG gene polymorphisms and the risk of RA. We conducted a hospital-based case-controlled study in Changzhou with 574 RA cases and 804 controls. The genotyping of RANK gene rs1805034 polymorphism was conducted by single base extension combined with matrix-assisted laser desorption/ionization time of flight mass spectrometry (MALDI-TOF-MS). We also undertook a meta-analysis of the literature referring to polymorphisms of RANK, RANKL and OPG genes and RA risk. This case-controlled study found that the polymorphism in the RANK gene rs1805034 was not related to RA risk. Stratification analyses by sex and age suggested that RANK gene rs1805034 polymorphism was not associated with the risk of RA among groups of male, female, age ≤ 55 and age > 55. Our meta-analysis found that the rs2277438 polymorphism in RANKL gene increased the risk of RA, whereas RANK gene rs1805034, OPG gene rs3102735, OPG gene rs2073618, OPG gene rs3134069 polymorphisms were not related to RA susceptibility. In conclusion, this case-controlled study and meta-analysis indicated that the RANKL gene rs2277438 polymorphism increased the RA risk, and that RANK gene rs1805034, OPG gene rs3102735, OPG gene rs2073618, OPG gene rs3134069 polymorphisms were not related to RA risk.
Editorial: Recent advances in intelligent robotic systems
Authors: Xu Xin , Liu Yong
Published: June 2019

This Editorial introduces the motivation and organization process of the special issue on intelligent robotic systems. The major contributions of the six papers published in the special issue are discussed. In these papers, three papers present recent progresses in robot navigation and localization in complex environments. One paper reports a new robot sensing approach. The other two papers address the problems in robot dynamics modeling and service modeling in human‐robot interaction.
Low-enthalpy Geothermal Energy Potential of Mine Water from Closured Underground Coal Mines in Northern Spain
Authors: Menéndez Javier , Loredo Jorge
Published: June 2019

The contribution of renewable energies to the world's total energy demand has increased particularly during the last decades, and they will continue gaining market share. The European energy and climate policies have as one of their targets 20% of final energy from renewable origin by 2020. Underground coal mines closured and flooded constitute large underground reservoirs that can be economically managed to supply geothermal energy (heating and cooling) by means of heat pumps. This paper analyzes the geothermal potential of the water stored inside the coal mines of the Asturian Central Coal Basin (ACCB) and the reduction of CO2 emissions compared to the use of fossil fuels. The results of the study that has been carried out show a capacity of 50 MWt. The potential for generation thermal energy is 112,000 MWh/year with an electric consumption of 14,000 MWh/year. The Coefficient Of Performance (COP) medium is 8 kWht/kWhe. The reduction of CO2 emissions compared to other fuel sources can reach 80%.
BINP electron-positron facilities
Authors: Shwartz D. , Astrelina K. , Balakin V. , Batrakov A. , Belikov O. , Berkaev D. , Bolkhovitianov D. , Emanov F. , Frolov A. , Gorchakov K. , Kasaev A. , Kirpotin A. , Koop I. , Krasnov A. , Lebedev N. , Levichev E. , Lysenko A. , Maltseva Yu. , Martishkin P. , Meshkov O. , Motygin S. , Murasev A. , Muslivets V. , Otboyev A. , Perevedentsev E. , Piminov P. , Prosvetov V. , Rogovsky Yu. , Semenov A. , Senchenko A. , Shatunov P. , Shatunov Yu. , Timoshenko M. , Vasiliev S. , Zemlyansky I. , Zharinov Yu. , Zhuravlev A.
Published: June 2019

The present status of two operating BINP electron-positron colliders VEPP-2000 and VEPP-4M is given.
Electro-weak production of pseudovector C-even heavy quarkonia in electron-positron collisions on Belle II and BES III
Authors: Achasov Nikolay
Published: June 2019

1. The X(3872) State as Charmonium χc1(2P)

2. The χc1 and χb1 production in the e+e−→ χc1/χb1 reaction
Exotic molecular states in the decays of vector bottomonia
Authors: Baru V. , Epelbaum E. , Filin A. A. , Hanhart C. , Nefediev A. V. , Wang Q.
Published: June 2019

The most recent experimental data for the decays of the vector bottomonium γ(10860) proceeding through the formation of the states Zb(10610) and Zb(10650) are analysed simultaneously using solutions of the Lippmann-Schwinger equations which respect constraints from unitarity and analyticity. The interaction potential in the open-bottom channels $ {B^{(*)}}{\bar B^*} $ contains short-range interactions as well as the one-pion exchange; both types of the interaction are taken into account fully nonperturbatively. This way, all parameters of the interaction are fixed directly from the data and the pole positions for the Zb’s are determined as a prediction. In particular, both Zb states are found to be described by resonance poles located on the unphysical Riemann sheets in the vicinity of the corresponding thresholds. The heavy quark spin symmetry (HQSS) is employed to predict, in a parameter-free way, the pole positions and the line shapes in the elastic and inelastic channels for the Zbs’ spin partner states WbJ with the quantum numbers J++ (J = 0, 1, 2). Such spin partners can be produced in radiative decays of the vector bottomonium Υ(10860) and are expected to be detected in the Belle-II experiment.
XYZ states at BESIII
Authors: Sun Zhentian
Published: June 2019

In this proceeding, I report the most recent experimental results from BESIII about the XYZ sates. Two new X(3872) decay modes are observed, which is X(3872) → ωJ/ψ and X(3872) → π0χc1(1P). Precise measurement of cross sections of various channels reveal more fine structure about Y states. To study the property of Zc states, the Jp of Zc(3900) is determined with partial wave analysis, and a hint of new decay mode of Zc±(3900) → ρ±ηc are observed.
An amplitude analysis of the process e+e-→ 4π in the center-of-mass energy range 900–2000 MeV with the CMD3 detector at the VEPP-2000 e+e- collider
Authors: Kozyrev E. A. , Akhmetshin R. R. , Amirkhanov A. N. , Anisenkov A. V. , Aulchenko V. M. , Banzarov V. Sh. , Bashtovoy N. S. , Berkaev D. E. , Bondar A. E. , Bragin A. V. , Eidelman S. I. , Epifanov D. A. , Epshteyn L. B. , Erofeev A. L. , Fedotovich G. V. , Gayazov S. E. , Grebenuk A. A. , Gribanov S. S. , Grigoriev D. N. , Ignatov F. V. , Ivanov V. L. , Karpov S. V. , Kazanin V. F. , Koop I. A. , Kirpotin A. N. , Korobov A. A. , Kozyrev A. N. , Krokovny P. P. , Kuzmenko A. E. , Kuzmin A. S. , Logashenko I. B. , Lukin P. A. , Mikhailov K. Yu. , Okhapkin V. S. , Pestov Yu. N. , Popov A. S. , Razuvaev G. P. , Rogovsky Yu. A. , Ruban A. A. , Ryskulov N. M. , Ryzhenenkov A. E. , Semenov A. V. , Shatunov Yu. M. , Shatunov P. Yu. , Shebalin V. E. , Shemyakin D. N. , Shwartz B. A. , Shwartz D. B. , Sibidanov A. L. , Solodov E. P. , Titov V. M. , Talyshev A. A. , Vorobiov A. I. , Zemlyansky I. M. , Yudin Yu. V.
Published: June 2019

A large data sample of e+e-→ 4π collected by the CMD-3 experiment at the VEPP-2000 e+ e− collider allowed for an amplitude analysis of the process e+e−→ 4π in the center-of-mass energy range 900–2000 MeV. Various intermediate components were distinguished and dominance of the ωπ0 and a1π amplitudes has been proved.
Measurements of Hadronic and Transition Form Factors at BESIII
Authors: Redmer Christoph Florian
Published: June 2019

Motivated by the need of experimental input to improve the Standard Model prediction of the anomalous magnetic moment of the muon aµ, the BESIII Collaboration started a dedicated program to measure hadronic cross sections as well as transition form factors (TFF) with high accuracy. The large data sets acquired by the BESIII Collaboration allow to exploit initial state radiation in order to study hadron production over a wide energy range, as well as two-photon collisions to study the momentum dependence of TFFs in the space like regime. The current status and ongoing investigations in both endeavors are discussed.
An extension of BDK event generator
Authors: Krachkov P. A. , Milstein A. I. , Rezanova O. L. , Shamov A. G.
Published: June 2019

An extension of the well known ee → 4l event generator of F. A. Berends, P. H. Daverveldt, and R. Kleiss is presented. This extension accounts for production of narrow resonances, as well as the initial state radiation. In addition, it allows one to simulate the production of l+ l−π+π− with the lepton pair and the pion pair in 1−− states.
Current status of luminosity measurement with the CMD-3 detector at the VEPP-2000 collider
Authors: Ryzhenenkov A.E. , Akhmetshin R.R. , Amirkhanov A.N. , Anisenkov A.V. , Aulchenko V.M. , Banzarov V.Sh. , Bashtovoy N.S. , Berkaev D.E. , Bondar A.E. , Bragin A.V. , Eidelman S.I. , Epifanov D.A. , Epshteyn L.B. , Erofeev A.L. , Fedotovich G.V. , Gayazov S.E. , Grebenuk A.A. , Gribanov S.S. , Grigoriev D.N. , Ignatov F.V. , Ivanov V.L. , Karpov S.V. , Kazanin V.F. , Koop I.A. , Korobov A.A. , Kozyrev A.N. , Kozyrev E.A. , Krokovny P.P. , Kuzmenko A.E. , Kuzmin A.S. , Logashenko I.B. , Lukin P.A. , Mikhailov K.Yu. , Okhapkin V.S. , Otboev A.V. , Perevedentsev E.A. , Pestov Yu.N. , Popov A.S. , Razuvaev G.P. , Ruban A.A. , Ryskulov N.M. , Shatunov Yu.M. , Shatunov P.Yu. , Shebalin V.E. , Shemyakin D.N. , Shwartz B.A. , Shwartz D.B. , Sibidanov A.L. , Solodov E.P. , Talyshev A.A. , Tolmachev S.S. , Vorobiov A.I. , Yudin Yu.V.
Published: June 2019

The CMD-3 detector started data taking at the electron-positron collider VEPP-2000 [1] in December 2010. The collected data sample corresponds to an integrated luminosity of 87 pb−1 in the c.m. energy range from 1.06 up to 2 GeV and 91 pb−1 from 0.32 to 1.06 GeV. The integrated luminosity was measured by counting e+e−→ e+e− and e+e−→ γγ events, allowing additional photons in the final state. Preliminary results of the luminosity measurement are presented for various energy ranges and its accuracy is estimated to be 1%.
Off-shell fermion polarization and t-quark production
Authors: Kaloshin Alexander , Lomov Vladimir
Published: June 2019

Standard calculation of the polarization of final electron for pure initial state may be reformulated as a problem of looking for the complete polarization axis of produced state. It gives method for calculation of polarization applicable for both final and intermediate state fermions. We discuss modification of the energy and spin projectors in theory with parity violation. The obtained projectors are used to give the most accurate parametrization of t-quark resonance curve and simultaneously for its off-shell polarization.
The antibacterial effect of sonication and its potential medical application
Authors: Kamineni Srinath , Huang Chifu
Published: June 2019

Introduction: Recent applications of ultrasonic probes include cataract removal and tennis elbow treatment. Early data support the use of ultrasonic probe debridement in the treatment of recalcitrant diabetic foot ulcers. No data are available concerning the potential antibacterial properties of the clinical grade, lower energy ultrasound probes. We investigated the effect of a clinically available ultrasonic debridement probe with respect to bacterial viability.

Methods: A commercially available Tenex sonication machine with a Tx1 probe was used for this study. Three bacterial strains, aerobic and anaerobic, were investigated, G-negative (Porphyromonas gingivalis) and G-positive bacteria (Staphylococcus aureus and Streptococcus gordonii). These bacteria were cultured and tested with sonication for varying lengths of time (10, 30, 60, and 120 s). The tested bacterial samples were plated, the number of colonies on each plate counted, and the anti-bacterial effect was calculated. Statistical analysis was conducted using a one-way analysis of variance.

Results: Sonication exhibited a significant time-dependent antibacterial effect. Statistically significant anti-bacterial effect was observed in all three species tested. When comparing the kill rate between the control and 120 s of sonication; S. gordonii had a 34% kill rate, S. aureus had a 60% kill rate, and P. gingivalis had a 64% kill rate. When comparing control to all of the time intervals tested, S. aureus kill rate was statistically significant at all times, S. gordonii was statistically significant at all times above 10 s, and P. gingivalis was only statistically significant at 120 s.

Conclusion: This study demonstrates that a clinically available ultrasonic probe has an antibacterial effect against a wide spectrum of gram-positive, gram-negative, aerobic and anaerobic bacterial species. This may partially explain the dramatic healing of long-standing recalcitrant diabetic ulcers debrided with this device and may have a place in treating pathologies with bacterial mechanisms.
Fasten bei Diabetes und arterieller
Hypertonie
Authors: Lischka Eva
Published: June 2019

In der menschlichen Entwicklungsgeschichte traten häufig Phasen auf, in denen
Nahrung nicht zur Verfügung stand. In solchen Fällen sicherte die Möglichkeit,
von den eigenen Reserven zu zehren, das Überleben der Spezies. Deshalb ist der
Fastenstoffwechsel evolutionsbiologisch fest in unseren Genen verankert. Richtig
angewendet kann man das Fasten aber auch therapeutisch einsetzen.
Diagnostische Bedeutung von epigenetischen Mechanismen und Markern der Myokardschädigung
Authors: Hein Lutz
Published: June 2019

Epigenetische Mechanismen steuern die Entwicklung, Reifung und Funktion von Herzmuskelzellen. DNA-Methylierung und Histonmodifikationen kontrollieren das Genprogramm einer Zelle. In Herzmuskelzellen sind etwa 10 000 Gene aktiv, die für Proteine kodieren. 5% dieser Gene sind spezifisch nur in Kardiomyozyten exprimiert. Bei akuter Myokardschädigung werden diese Proteine aus den Herzmuskelzellen in das Blut freigesetzt und können dort detektiert werden, z. B. mit einem hoch-sensitiven Test für kardiales Troponin. Bei chronischer Myokardschädigung, z. B. bei chronischer Herzinsuffizienz, wird in überlebenden Kardiomyozyten ein pathologisches Genprogramm aktiviert, das epigenetisch gesteuert wird. So werden die Gene für die natriuretischen Peptide ANP und BNP durch Histonacetylierung aktiviert, sodass mehr ANP- und BNP-Peptide im Blut erscheinen, wo sie als diagnostische Marker der Herzinsuffizienz verwendet werden können. Epigenetische Regulatoren spielen auch eine wichtige Rolle bei der Herzentwicklung: Bei bis zu 10% der angeborenen Herzfehler konnten Genmutationen – vor allem in epigenetischen Regulatoren – festgestellt werden.
Insulin Sensitivity, Depression/Anxiety, and Physical Fitness in At-Risk Adolescents
Authors: Bruggink Stephanie M. , Shomaker Lauren Berger , Kelly Nichole R. , Drinkard Bart E. , Chen Kong Y. , Brychta Robert J. , Cassidy Omni , Demidowich Andrew P. , Brady Sheila M. , Tanofsky-Kraff Marian , Yanovski Jack A.
Published: June 2019

Poor physical fitness contributes to the early progression of cardiometabolic disease, yet the physiological and psychological factors underpinning poor fitness in at-risk adolescents are not well understood. In this study, we sought to determine the relationship of physical fitness with two developmental phenomena of adolescence, insulin resistance and depression/anxiety symptoms among at-risk youth. We conducted secondary data analyses of 241 overweight or obese adolescents (12–17 years), drawn from two study cohorts. Insulin sensitivity index was derived from oral glucose tolerance tests. Adolescents self-reported depressive symptoms and anxiety symptoms on validated surveys. A walk/run test was administered to determine perceived exertion and physical fitness (distance traveled). Insulin sensitivity was positively associated with walk/run distance (b=0.16, P<0.01), even after accounting for all covariates. Anxiety symptoms were inversely related to perceived exertion (b=–0.11, P<0.05), adjusting for covariates. These findings suggest that insulin resistance and anxiety symptoms are associated with different dimensions of physical fitness in overweight or obese adolescents and could both potentially contribute to declining fitness and worsening metabolic outcomes in at-risk youth.
Maternal Thyroid Hormone Deficiency During Gestation and Lactation Alters Metabolic and Thyroid Programming of the Offspring in the Adult Stage
Authors: Tapia-Martínez Jorge , Torres-Manzo Alejandra Paola , Franco-Colín Margarita , Pineda-Reynoso Marisol , Cano-Europa Edgar
Published: June 2019

Environmental stimuli during critical developmental stages establish long-term physiological and structural patterns that “program” health during adult life. Little is known about how alterations in hormonal supply might have consequences in metabolic and thyroid programming. This work aims to prove that alterations in the supply of thyroid hormones during gestation and lactation have long-term consequences in the metabolic and thyroid programming of the offspring. Female Wistar rats were divided into euthyroid, hypothyroid, and hypothyroid with 20 μg/day of s.c. thyroxine (T4), replacement wet nurses. Rats were mating, and after birth, pups were grouped according to their wet nurses group. Milk quality of wet nurses was assessed on days 7, 14, and 21. Body mass gain and energy intake of the offspring were monitored for 28 weeks after weaning. At sacrifice, we extracted and weighed their thyroid gland and adipose reserves, and collected blood to measure its metabolic and thyroid profiles. Hypothyroid wet nurses presented a persistent low quality of milk, while both male and female hypothyroid offspring presented lower body mass gain, higher blood glucose, dyslipidemia, hyperinsulinemia, and hyperleptinemia, as well as lower total adipose reserves, but higher visceral reserve, diminished T3 and T4 concentrations, and lower weight of thyroid gland. Thyroxine replacement prevented all changes in both wet nurses and pups. We conclude that maternal thyroid hormone deficiency during congenital and lactation stages alters the metabolic and thyroid programming of the offspring, while the reestablishment of maternal thyroid status during critical periods of development can prevent these alterations.
Comparison of a Bridge Immunoassay with Two Bioassays for Thyrotropin Receptor Antibody Detection and Differentiation
Authors: Allelein Stephanie , Diana Tanja , Ehlers Margret , Kanitz Michael , Hermsen Derik , Schott Matthias , Kahaly George J.
Published: June 2019

A rapid and fully automated chemiluminescent immunoassay for the detection of thyrotropin receptor autoantibodies (TSHR-Ab) based on a bridge technology was compared with two bioassays that measure either stimulating (TSAb) or blocking (TBAb) antibodies for the detection and differentiation of TSHR-Ab. A total of 229 patients with various thyroid disorders [151 with Graves’ disease (GD), 35 with Hashimoto’s thyroiditis (HT), 32 with nodular goiter, and 11 with thyroid cancer] were included. The bridge immunoassay was performed according to the manufacturer’s instructions (cut-off>0.55 IU/l). TSAb and TBAb were measured with reporter bioassays. Blocking activity was defined as percent inhibition of luciferase expression relative to induction with bovine TSH alone (cut-off>34% inhibition). TSAb was reported as percentage of specimen-to-reference ratio (> 140 SRR%). The 3 TSHR-Ab assays were negative in all patients with benign euthyroid nodular goiter and differentiated thyroid cancer. In contrast, in all patients with GD, irrespective of the disease duration, TSHR-Ab positivity was present in 127 of 151 (84%) and 140 (93%) for the bridge assay and TSAb bioassay, respectively (p<0.001). Fifteen of 151 (10%) GD samples were positive in the TSAb bioassay but negative in the bridge assay. The bridge assay and the TSAb bioassay correlated positively (r=0.39, p<0.0001) in patients with GD. Both assays detected TSHR-Ab in all ten untreated hyperthyroid patients with GD. In GD patients with a duration of less than six months, 27/29 (93%) and 28 (97%) were TSHR-Ab positive with the bridge and TSAb bioassay, respectively. In comparison, TSHR-Ab were present in two of 35 (6%) and five (14%) HT patients with the bridge and TSAb bio-assay, respectively. TSHR blocking antibodies were present in one (3%) patient with HT and in two (1%) patients with GD; these two GD patients were also bridge assay positive but TSAb bioassay negative. In conclusion, the bridge immunoassay and both bioassays are highly sensitive for the detection of TSHR-Ab. The bridge assay is, however, also positive in the presence of TSHR blocking antibodies detected in a TBAb bioassay.
Transition Metal-Catalyzed Directed C(sp3)–H Functionalization of Saturated Heterocycles
Authors: Antermite Daniele , Bull James A.
Published: June 2019

Synthetic methods that can readily access saturated heterocycles with different substitution patterns and with control of stereo- and regiochemistry are of huge potential value in the development of new medicinal compounds. Directed C–H functionalization of simple and commercially available precursors offers the potential to prepare diverse collections of such valuable compounds that can probe the different available exit vectors from a ring system. Nonetheless, the presence of the Lewis basic heteroatoms makes this a significant challenge. This review covers recent advances in the catalytic C–H functionalization of saturated heterocycles, with a view to different heterocycles (N, O, S), substitution patterns and transformations.

1 Introduction

2 α-C–H Functionalization with Directing Group on Nitrogen

3 C–H Functionalization at Unactivated C(3), C(4), and C(5) Positions

3.1 C–H Functionalization at C(3) with Directing Groups at C(2)

3.2 C–H Functionalization at C(3), C(4), and C(5): Directing Groups at C(4) and C(3)

4 Transannular C–H Functionalization

5 Conclusion
Is There a Role for Ileal Pouch Anal Anastomosis in Crohn's Disease?
Authors: Lopez Nicole E. , Zaghyian Karen , Fleshner Phillip
Published: June 2019

Traditionally, surgical interventions for colonic Crohn's disease (CD) have been limited to total abdominal colectomy and ileorectal anastomosis, or total proctocolectomy with end ileostomy if there is rectal involvement. However, improved understandings of the biology of CD, as well as the development of biologic therapies, have enabled more limited resections. Here, we review the indications for, and limitations of, specific procedures aiming to preserve intestinal continuity in colonic CD.
WertschöPfungsorientierter Einkauf: Qualität wird zum Maßstab
Authors: Schlüchtermann Jörg , Bächer Franziska
Published: June 2019

Spätestens seitdem die Bundesregierung das IQTiG (Institut für Qualitätssicherung und Transparenz im Gesundheitswesen) gegründet hat, wissen Krankenhäuser, dass die Behandlungsqualität kontinuierlich zu steigern ist, natürlich ohne dabei die Kosten aus dem Blick zu verlieren. Welchen Beitrag kann der Krankenhaus-Einkauf dazu leisten?
Portfolio-Technik: Planungshilfe für den Strategischen Einkauf
Authors: Schlüchtermann Jörg , Köhler Mathias
Published: June 2019

Um den Krankenhauseinkauf konsequent strategisch auszurichten, braucht es geeignete Planungsinstrumente. Portfolio-Konzepte haben nicht nur einen festen Platz bei der Ausrichtung der Strategischen Geschäftsfelder von Unternehmen, sie können auch für die Beschaffung wertvolle Dienste leisten.
Kommentar: Gemeinsam aus Weniger mehr Machen
Authors: Jakobs-Schäfer Adelheid
Published: June 2019

Das Thema der Zukunft heißt Vernetzung. Der Klinikeinkauf intensiviert hierfür die Zusammenarbeit mit der Industrie und auch in der Logistik bewegen wir uns in Richtung potenter Netzwerke für Kliniken. Die fortschreitende Digitalisierung sorgt für immer neue Impulse.
Kommentar Zum Prospitalia Jahreskongress: Netzwerken als Schlüssel für einen Erfolgreichen Krankenhauseinkauf
Authors: Wild Markus
Published: June 2019

Gemeinsam erreichen wir mehr. Dieser Grundsatz ist für den Krankenhauseinkauf, aber auch für die Medizintechnikindustrie aktueller als je zuvor. Für alle Vertreter des Gesundheitswesens ist der konsequente, regelmäßige und partnerschaftliche Austausch essentiell, um auch in Zukunft erfolgreich im Markt agieren zu können.
Digitale Prozessanalyse im Krankenhaus: Bewegung Sichtbar Machen
Authors: Laciok Sylvia , Wibbeling Sebastian
Published: June 2019

In Kliniken bilden die vielen manuellen Prozesse häufig eine Blackbox, über die in der Regel keine Informationen vorliegen. Die Digitale Prozessanalyse bildet eine Methode zur Analyse dieser Prozesse und nutzt dazu Mini-Sensorik und KI. So werden Prozesskennzahlen ermittelt und Optimierungspotentiale im Bereich der Effizienz und Ergonomie aufgedeckt.
Bündelung von Versorgungsleistungen: Artemed setzt auf Logistische Versorgungskonzepte
Authors: Jaeger Thomas
Published: June 2019

Durch die Zusammenarbeit mit externen Dienstleistern können die Kosten bei der Warenbeschaffung optimiert und die Versorgung kann logistisch gebündelt werden. Somit gewinnen Einkaufsabteilungen wertvolle Zeit, sich um die strategischen Kernaufgaben des Klinikeinkaufs zu kümmern.
A DuMond-type crystal spectrometer for synchrotron-based X-ray emission studies in the energy range of 15–26 keV
Authors: Jagodziński P. , Szlachetko J. , Dousse J.-Cl. , Hoszowska J. , Szlachetko M. , Vogelsang U. , Banaś D. , Pakendorf T. , Meents A. , van Bokhoven J. A. , Kubala-Kukuś A. , Pajek M. , Nachtegaal M.
Published: June 2019

The design and performance of a high-resolution transmission-type X-ray spectrometer for use in the 15–26 keV energy range at synchrotron light sources is reported. Monte Carlo X-ray-tracing simulations were performed to optimize the performance of the transmission-type spectrometer, based on the DuMond geometry, for use at the Super X-ray absorption beamline of the Swiss Light Source at the Paul Scherrer Institute. This spectrometer provides an instrumental energy resolution of 3.5 eV for X-ray emission lines around 16 keV and 12.5 eV for emission lines at 26 keV, which is comparable to the natural linewidths of the K and L X-ray transitions in the covered energy range. First experimental data are presented and compared with results of the Monte Carlo X-ray simulations.