bluuebunny/crossref_metadata_2025 huggingface dataset:
An in silico Drug Repurposing Study to Inhibit the Spike Protein of SARS-CoV2
Authors: Abdollahpour Soha , Rahbar Azam , Mohammadhassan Reza , Talebi Yasamin , Bahrami Hesari Yegane
Published: September 2024

SARS-CoV2 has caused the recent mortal pandemic known as COVID-19. The drug repurposing approach can be employed to find the potential drugs capable of binding SARS-CoV2 structural and nonstructural proteins. The present study aimed to repurpose some common FAD-approved antiviral and non-antiviral drugs computationally for SARS-CoV2 treatment. In the in silico study, 89 FDA-approved drugs and Remdesivir, as the control, were analyzed by molecular docking to inhibit the SARS-CoV2 spike (S) protein as the key player in virus-cell binding. First, the Uniport website was used to find receptor and ganglioside binding domains (RBD and GBD, respectively) of the S protein as the target. The structure of the target was downloaded from RCSB, and 'the ligands' structures were downloaded from PubChem. All structures were refined using SPDV and PyRx software. AutoDock Vina was employed for the docking process. The result showed that 8 drugs, including Ledipasvir, Montelukast, Domperidone, Aprepitant, Folic acid, Losartan, Ticagrelor, and Rivaroxaban, can bind S protein and then inhibit the protein function. In addition, Ledipasvir, Montelukast, and Domperidone can bind GBD of the S protein with higher binding energy (-8.2, -8, -7.9 kcal/mol, respectively). On the other hand, higher RBD binding energy was calculated for Ticagrelor (-6.9 kcal/mol), Folic acid, Montelukast, and Domperidone (-6.5 kcal/mol). Generally, the ligands could inhibit GBD more than RBD. According to the binding energy to S protein and low side effects of the studied medications, Ledipasvir and Losartan can be introduced as the most effective candidates for repurposed drugs. Also, Gly496 and Asn137 are the most engaged amino acids in the ligand-receptor interaction from RBD and GBD, respectively.
Electronic Governance and Service Delivery in Abia State University Uturu Nigeria – The nexus: Interrogating the Praxis and prospects
Authors: Chukwuemeka Emma , Egwuagu Bridget , Abba Ugoo
Published: September 2024

The study interrogates the nexus between electronic governance and improved performance in Abia State University Uturu.. The study adopted sample survey research design, while tables, mean and regression analysis were used as analytical technique for the study. The study revealed among others that electronic administration has significant effect on the performance of Abia State University, electronic registration significantly effects academic excellence of Abia State University and electronic administration has significant effect on the performance of Abia State University. The study recommends that Abia State University should improve on the current ICT infrastructure and strategy, and continue to improve on its internet access and digital divide among staff in order to continue achieving their organizational goals which will engender sustainability. Given the strategic role of ICT in the 21st century administration, Abia State University should continue to expand windows of opportunities that ICT provides in its drive to further enhance employees’ performance (by acquiring new skills, knowledge and abilities) that will invariably improve workers’ performance and organizational success.
Ameliorative Effects of Spondias Mombin Aqueous Leaf Extract on The Sperm Characteristics of Alloxan-Induced Diabetic Male Wistar Rats
Authors: Oloye Abimbola A. , Adekoya Oluwatodimu A. , Awonuga David B. , Mustapha Lukman , Olurode Sikiru A , Adetomiwa Abiodun Seun , Bassahwa Akyang P.
Published: September 2024

Considerable efforts have been directed towards addressing diabetes-induced infertility. In a twophase study designed to determine the effect of Spondias mombin (SM) aqueous leaf extract on blood glucose, spermiogram and gonadosomatic index of diabetes-induced  wistar rats, forty male Wistar rats (170 - 250g) were randomly divided into ten groups (n=4) with five treated for 7 days for the first phase  and five treated for 14 days in the second phase. Each phase had their five groups randomly assigned into control (non-diabetic), diabetic  (untreated), diabetic concurrently treated with 5 mg/kg glibenclamide, 400mg/kg SM and 800 mg/kg SM. Diabetes mellitus was  induced with intraperitoneal administration of alloxan hydrate at a dosage of 158mg/kg. Rats with fasting blood glucose of ≥ 190 mg/dL  three days post alloxan administration was considered diabetic. Following this, the test substances were administered daily via oral  gavage for 7 or 14 days. Blood glucose levels, spermiogram, body weight changes, gonadosomatic index (GSI), and testicular weights  were evaluated at the end of each phase. Results revealed that SM caused a reduction in the blood glucose in a dose-dependent manner  in alloxan-induced diabetic rats. In both phases, 800 mg/kg SM dosage improved the sperm motility and concentration. Also, at 400mg/ kg dosage, after 14 days of administration SM caused a progressive improvement in the sperm motility and concentration. The percentage of abnormal sperm cells varied between control and treatment groups but remained within the range of 18.50% to 57.00%  after 14 days of treatment. The GSI was highest in 800 mg/kg SM group after 14 days when compared with other groups. This study  concluded that the aqueous S. mombin leaf extract exhibited an ameliorative effect on diabetes-induced infertility when administered at  dose of 800 mg/kg between 7 and 14 days.
Evaluation of Sources of Information for Raising Village Chickens in Bauchi State, Nigeria (Short Communication)
Authors: Garba Sule Adamu
Published: September 2024

An evaluation of sources information for raising village chickens was conducted among 72 farmers from nine communities in Bauchi  State, Nigeria. Eight farmers were selected based on their experience and ownership of more than 20 chickens by members of the  community during a group discussion session held with farmers, poultry traders and butchers and community leaders. The result  showed respondents were mostly full-time farmers (65.3%) who were married (98.4%) and over 18 years of age with over 5 years of  experience in village chicken farming (77.8%). A combination of Radio and community were identified by most respondents (32%) as their  major source of information on village chicken production. Schools, on the contrary, were the least reported source of agricultural  information (3%). Diversifying sources of information could likely enhance the effectiveness of reaching farmers with technical  information on raising village chickens.
Uso da Análise de Cluster em Avaliação Diagnóstica para Mapeamento de Defasagem Escolar
Authors: Costa do Nascimento Juliana , Brom Pedro Carvalho , Braga Bruno Marx de Aquino
Published: September 2024

Como proposição de pesquisa, esse trabalho irá apresentar uma possibilidade para mensurar e identificar por meio de avaliação diagnóstica, conhecimentos de matemática que estão em defasagem. Considerando que avaliação pode ser usada como leitura de pré requisitos que os estudantes possuem, propomos um diagnóstico que pode ser aplicado em larga escala, sem perder o foco no atendimento de grupos menores e/ou individuais. O método consiste no uso da análise de cluster mapeando estudantes com defasagens semelhantes a fim de obter, de modo técnico, a condição dos alunos que chegam no ensino médio do Instituto Federal de Brasília. A partir desta análise basal, apresentamos a forma de mapear este cenário.
O processo de imaginação pedagógica na perspectiva da educação inclusiva: influências na formação inicial de professores de Matemática
Authors: Cintra Vanessa de Paula , Costa Lopes Jessica
Published: September 2024

Neste texto, analisamos aspectos relevantes da formação inicial de alunos do curso de Matemática que cursaram uma disciplina de Prática como Componente Curricular II, que aborda de forma interdisciplinar práticas para o ensino de Geometria em ambientes inclusivos, apoiada principalmente na Imaginação Pedagógica. É uma pesquisa qualitativa e os dados foram coletados por meio de questionários respondidos pelos participantes e de observações das aulas, os quais foram analisados segundo a Análise de Conteúdo. Pudemos identificar contribuições à formação inicial dos licenciandos, ao imaginarem práticas inclusivas nas aulas de Matemática, com possibilidades para transformar a situação em um cenário de inclusão, proporcionando a reflexão e criticidade sobre a prática pedagógica, de forma a (re)construir a identidade pessoal e a consolidar o saber docente. Por fim, destacamos a importância da inserção de futuros professores em um ambiente educacional que proporcione o diálogo inclusivo e lhes possibilite novos conhecimentos e o direito à educação para todos.
Digital oncology, the dawn of a new era turning the clock back on tumor mass
Authors: Afrasiabi Kambiz
Published: September 2024

Evolutionary path of cancer therapeutics which started around eighty-two years ago, following serendipitous discovery of nitrogen mustard [1] has been guided by an accelerated pace of new discoveries, an ever-increasing depth of understanding of intracellular biological processes [2] and application of advances made in other fields of science [3].

Success in any field, especially in cancer medicine, is based on embracing evolution in understanding other scientific fields [4] and its application to the forward move in cancer therapeutics. As such, we have gone through discovery of a diverse group of therapeutics, targeting different sub compartments of growth and proliferation pathways [5] and taking advantage of their synergistic efficacy, in different combinations [6]. Dissection of immune regulatory pathways [7] and their interaction with cancer cell has led to the generation of modern immune therapeutic agents. Single-cell sequencing technology [8] has paved the way for the development of spatial omics [9], which has opened the way on deeper understanding of tumor evolutionary path [10]. This would give us the opportunity to design a new generation of cancer therapeutics [11] intercepting with the forward evolutionary path of tumor mass.

Along this path, we face insurmountable barriers in developing meaningful and game changing treatment strategies by directing single changes in a hyper complex biological system [12], manifested by complexities of genome [13], epigenome [14], microRNA network [15], gene regulatory mechanisms [16], and protein-protein interactions [17]. Consequently, we need to search for a solution that enables us to freeze or slow down the forward evolutionary path of tumor mass [18], by making a single change in a game changing variable of cancer cell.
Nuclear factor kappa-B: The El Dorado of inflammatory immune response
Authors: Mukherjee Sumon , Dutta Saikat , Pati Subhadip , Sarkar Tania , Paul Silpita , Chakraborty Sourio , Basak Udit , Dhar Subhanki , Das Tanya , Sa Gaurisankar
Published: September 2024

For more than a decade, the nuclear factor kappa-B (NFκB) family and their signaling pathways have proved crucial to the immune system's functioning. According to research, this factor is implicated in almost every immune system event, including immune cell development and function, activation, and pathogen-activated cell death. A considerable body of evidence suggests the idea that, in addition to being a possible transcription factor, it plays a very significant role in the establishment of inflammation-associated immunological responses in host cells. Inflammation is a cascade of events that involve vasodilation and immune cell migration to the site of infection in order to defend the host. However, if dysregulation occurs, it may lead to the emergence of chronic inflammatory illnesses. When immune cells migrate to an inflamed area NFκB activation occurs, which causes release of pro-inflammatory cytokines and development of inflammatory response. Furthermore, this complex transcription factor activation takes part in several innate and adaptive immunity-related cellular processes, including immune cell proliferation and differentiation. Grasp the relationship between the immune system and inflammation requires a thorough understanding of NFκB's capabilities. This review explores the role of NFκB activity as a key inflammatory mediator in various malignancies and auto-inflammatory diseases. We have shed light on how NFκB regulates inflammatory responses by producing cytokines and chemokines and directing the transcription of inflammatory molecules involved in both innate as well as adaptive immunity.
DINAMIKA KEBIJAKAN PUBLIK DALAM MEWUJUDKAN PENGEMBANGAN WILAYAH YANG BERKELANJUTAN
Authors: Sinaga Kariaman
Published: September 2024

Kebijakan pengembangan wilayah dapat dilihat mulai awal perencanaan (ex-ante), evaluasi pelaksanaan kebijakan (on-going), maupun evaluasi atas pelaksanaan kegiatan kebijakan public (ex-post)) sehingga kebijakan dalam pengembangan wilayah dapat menghasilkan perbaikan-perbaikan untuk meningkatkan hasil kebijakan sesuai dengan kebutuhan masyarakat. Kabijakan pengembangan wilayah juga tidak terlepas dari konsep good governance yang meliputi: konsistensi, transparansi, akuntabilitas, keadilan, partisipatif, efektivitas, dan efisiensi. Penulisan dilakukan melalui hasil analisis melalui sumber-sumber atau referensi yang terkait dengan kebijakan publik. Pembahasan tentang kebijakan publik memiliki cakupan yang sangat luas sehingga memerlukan batasan dalam pembahasan sesuai dengan konteks pengembangan wilayah melalui kebijakan di level nasional maupun di level daerah. Dinamika kebijakan publik merupakan fenomena yang berkembang pada suatu wilayah atau daerah sesuai dengan situasi dan kondisi yang suatu wilayah. Berbagai faktor dapat mempengaruhi pelaksanaan kebijakan publik dalam rangka pengembangan wilayah yang berkelanjutan yang dapat dilihat melalui dinamika kebijakan yang berkembang. Dalam pelaksanaannya kebijakan pengembangan wilayah yang dilakukan masih menunjukkan kurangnya penerapan keberlanjutan. Penilaian atas kurangnya keberlanjutan dapat dilihat berdasarkan pada pelaksanaan pembangunan yang belum melibatkan pihak-pihak yang harus dilibatkan dalam pelaksanaan keputusan kebijakan pengembangan wilayah. Dengan tidak terlibatnya pihak pemerintah, pihak swasta, dan pihak masyarakat maka dapat dipastikan tidak adanya kebersamaan, konsistensi, dan kesinambungan suatu program. Hasil dari pengembangan wilayah juga dapat dilihat berdasarkan wilayah tertentu yang memiliki otonomi dan kualitas pelaksanaan keputusan kebijakan yang berbeda.
MANAJEMEN KONFLIK TERHADAP KASUS BANJIR ROP AKIBAT REKLAMASI PELABUHAN BELAWAN
Authors: Saragi Siswati
Published: September 2024

Potensi laut Indonesia bukan hanya dari aspek hasil kekayaan yang terdapat di dalam nya, potensi wisata tetapi juga potensi alur lalu lintas laut dari dalam maupun dari luar wilayah Indonesia. Menghadapi perkembangan tersebut, maka Pelindo I melakukan perluasan wilayah dengan melakukan reklamasi. Namun ternyata  reklamasi ini memunculkan permasalahan baru yang menyangkut pada kehidupan masyarakat nelayan dan yang bertempat tinggal di pesisir pantai dan berdekataan dengan pelabuhan Belawan tersebut. Kota Belawan sebagai kota tempat keberadaaan pelabuhan Pelindo I juga mengalami banjir rob yang semakin lama semakin parah. Permasalahan banjir yang dihadapi masyarakat Belawan sudah banyak mendapat perhatian dari berbagai pihak. Lalu bagaimana peranan pemerintah dalam menengahi konflik antara masyarakat dan pihak perusahaan? Mediator yang netral dapat membantu memfasilitasi dialog antara pihak-pihak yang bersengketa, membantu mencari solusi yang adil dan memfasilitasi kesepakatan antara pemerintah dan masyarakat. Metode yang digunakan dalam penulisan ini adalah dengan menggunakan berbagai tulisan, hasil penelitian maupun peraturan perundang-undangan yang berhubungan dengan kebijakan dalam reklamasi, linkungan hidup, maupun hal-hal lain yang bersangkutan.
Transición ecológica: riesgos emergentes y nuevos desafíos preventivos en salud laboral
Authors: Igartua Miró María Teresa
Published: September 2024

La transición ecológica tiene repercusiones en la salud laboral, planteando nuevos desafíos preventivos. Realidad vislumbrada en las Estrategias europea y española de Seguridad y Salud en el Trabajo que apuntan a la investigación, la promoción y la elaboración de un marco teórico para futuras propuestas ante un problema “incipiente”. Dada la presión de tiempo, a la espera de su concreción, se analizan los principales riesgos y necesidades, examinando la aplicación de la LPRL a los fenómenos climáticos y atmosféricos y a los sectores más afectados por el proceso, incidiendo en la evaluación y flexibilización del tiempo de trabajo, obligaciones “reforzadas” por el RDL 4/2023 para episodios de elevadas temperaturas, además de alentar el protagonismo de los agentes sociales y la negociación colectiva y avanzar algunas propuestas.
Neuropsicología de los trastornos del neurodesarrollo en contexto educativo
Authors: Mejía Navas Cristian Ricardo , Madrid Díaz Melane Patricia , García Orellana Mayra Stephany , Cordón Fuentes Jennifer Dayana
Published: September 2024

PROBLEMA: los trastornos del neurodesarrollo son un desafío desde la perspectiva neuropsicológica dentro del contexto educativo nacional. OBJETIVO: determinar el abordaje neuropsicológico que se aplican a los trastornos del neurodesarrollo en el contexto educativo en Guatemala. MÉTODO: se realizó una revisión bibliográfica de los artículos científicos que abordaron temas sobre el impacto de los trastornos del neurodesarrollo en el ámbito educativo. RESULTADOS: se recopiló información de varios estudios en donde se describen las funciones neurofisiológicas, neuroanatómicas y los fundamentos neurocientíficos acerca de los trastornos del neurodesarrollo enfocados en la educación y también basados en los criterios descritos en el Manual Diagnostico y Estadísticos de los trastornos mentales, conociendo el área de intervención de cada uno de los trastornos y describiendo los tratamientos y pruebas psicológicas que se pueden aplicar. CONCLUSIÓN: los trastornos del neurodesarrollo son conocidos por la limitación en la adquisición de habilidades que predominan y afectan el área social, académica, motora y cognitiva, afectando directamente al niño y familiares obteniendo la oportunidad de por medio de un diagnóstico en donde se facilita el acceso a tratamientos y posteriormente son evaluados por los criterios diagnósticos del paciente y las necesidades que puedan presentar.
Neuroeducación y factores socioambientales para el adecuado desarrollo académico en estudiantes universitarios
Authors: González Dardón Wendy Roxana
Published: September 2024

PROBLEMA: los factores socioambientales juegan un papel importante para el adecuado desempeño académico. En el contexto guatemalteco, aproximadamente el 50% de los jóvenes matriculados para estudios universitarios logran obtener un título a nivel superior. Se hace necesario identificar diversos factores socioambientales que contribuyen para que esto sea posible y los diferentes factores de riesgo que están latentes y que pueden afectar en la sociedad juvenil.  OBJETIVO: identificar los diferentes factores socioambientales para el adecuado desarrollo académico de jóvenes universitarios y la importancia de la neuroeducación en este proceso. MÉTODO: esta investigación es de tipo transversal, se realiza de forma descriptiva, con enfoque analítico, para lo cual se consideró base bibliográfica y una muestra de 80 jóvenes universitarios, que residen en Guatemala y estudian en la capital e interior de la república. RESULTADOS: los centros de estudio a nivel superior deben contar con profesionales que conozcan y ejerzan desde la neuroeducación y se considera importante que el éxito de la sociedad juvenil en lograr un título universitario es la conjugación de habilidades personales y factores socioambientales que contribuyen en el proceso.  CONCLUSIÓN: los factores socioambientales tienen un papel primario para el éxito de la vida académica de los estudiantes universitarios.
Metaconocimiento emocional y autoeficacia materna en madres de infantes de 0 a 2 años
Authors: Estrada Orellana Angélica María
Published: September 2024

PROBLEMA: la facilidad, dificultad o carencia de autorregular los estados emocionales influye en las habilidades neurocognitivas y afectivas que utilizan las mujeres para afrontar y adaptarse a los cambios sustanciales en la vivencia de la maternidad y en sus expectativas para desempeñar con eficacia su rol materno. OBJETIVO: relacionar los niveles de metaconocimiento emocional con el rango de percepción de autoeficacia materna. MÉTODO: estudio descriptivo transversal realizado en 105 mujeres madres de infantes de 0 a 2 años utilizando la escala Train Meta-Mood Scale (TMMS) para evaluar el metaconocimiento emocional y la Escala de evaluación parental (EEP) para valorar la satisfacción y sentimientos de autoeficacia en la maternidad. RESULTADOS: se evidencia que el  70.5% debe mejorar su claridad emocional, el 65.7% presta poca atención emocional, el 55.2% cuenta con adecuada reparación emocional, la media y desviación estándar de los resultados de los rangos de eficacia materna demuestra que la mayoría de la población presenta alta percepción, utilizando el coeficiente de Spearman se constata que no existe diferencia significativa entre los niveles de metaconocimiento  emocional con el rango de percepción de  autoeficacia materna. CONCLUSIÓN: las mujeres madres de infantes de 0 a 2 años, priorizan el cumplir de forma eficaz su rol materno, pero prestan poca atención a potenciar sus habilidades de metaconocimiento emocional.
Impacto de la estimulación sensorial y cognitiva en la primera etapa del neurodesarrollo infantil
Authors: Cordón Lemus Sandy Lorely
Published: September 2024

PROBLEMA: estimulación sensorial y cognitiva que presentan los niños entre las edades de 3 a 6 años, durante esta fase inicial desempeña un papel vital en la formación de conexiones neuronales y en la construcción del futuro del niño, es el inicio del desarrollo humano, especialmente durante la niñez temprana, constituye un período de transformaciones y progresos rápidos. OBJETIVO: proporcionar un análisis detallado y comprensivo de cómo la estimulación sensorial y cognitiva influye en el neurodesarrollo infantil en sus primeros años, se busca mejorar las prácticas educativas y de atención para optimizar el crecimiento y el aprendizaje. MÉTODO: a través del enfoque cualitativo, con enfoque analítico, el universo total es de 16 niños entre las edades de 3 a 6 años. RESULTADOS: mediante los datos recopilados de 16 participantes, en una división de género de 60% niños y 40% niñas, con un nivel socioeconómico bajo, en la estimulación sensorial el 100%  en aspecto visual, olfativo y gustativo y un 90% auditiva y un 80% en táctil, en relación con la estimulación cognitiva, un 100% de los participantes reciben estimulación en atención y pensamiento, el 80% en memoria y inteligencia. CONCLUSIÓN: los participantes han estado expuestos a la estimulación cognitiva, incluyendo la atención y el pensamiento. Además, la mayoría de los participantes han experimentado la estimulación de la memoria (80%) y la inteligencia (80%) y en la estimulación cognitiva la mayoría de los participantes han experimentado la estimulación de la memoria (80%) y la inteligencia (80%).
Impacto de la lectura inicial en el neurodesarrollo infantil
Authors: Armas Bran Henri André
Published: September 2024

PROBLEMA: los infantes tienen algún cambio en el cerebro cuando aprenden a leer. OBJETIVO: el objetivo del estudio es establecer por medio de un examen de habilidades y destrezas de lectura inicial el nivel de avance que han obtenido los estudiantes de párvulos del Centro Educativo Mixto Monte Real y como esta área de enseñanza apoya el desarrollo del cerebro. MÉTODO: análisis descriptivo de los datos recabados en el examen de pre lectura de Marion Monroe.  Los sujetos participantes en la investigación son estudiantes de 5 a 7 años que cursan el grado de párvulos en el establecimiento escolar Monte Real el cual se encuentra en San Pedro Sacatepéquez municipio de Guatemala. RESULTADOS: se determinó el nivel de desarrollo de lectura a través de analizar hábitos, relación con sensaciones, habilidad para retener detalles, semejanza de objetos y conocimiento de palabras, al mismo tiempo se comparó resultados, progreso e impacto en el neurodesarrollo con relación a la edad del alumno. CONCLUSIÓN: la neurociencia ayuda a comprender, conocer la configuración y organización del cerebro en las etapas de la lectura inicial, además describe el impacto en el neurodesarrollo infantil.
METONIMIJA TIPA ’PREDMET ZA RADNjU’ FORMALIZOVANA INSTRUMENTALOM S PREDLOGOM „ZA“
Authors:   University of Novi Sad, Faculty of Philosophy, Serbia, Dražić Jasmina N.
Published: September 2024

The paper analyzes examples of compact structures with spatial meaning, formalized by a preposition za (i.e. at / behind, next to) and a noun in the instrumental (eg. On je za volanom i.e. he is behind the wheel, on je za knjigom, i.e. he is always behind the book, etc.). The aim of the paper is to examine the inventory and range of such nouns, their semantics and indicators for possessing the ability to perform the function of the transferor in the metonymic relation- ship SUBJECT FOR ACTION, as well as the meaning of the preposition za in this structure in the light of cognitive postulates. The basis for the analysis are modern cognitive-linguistic theories about conceptual metonymy, which are based on the research of A. Barcelona, G. Radden, Z. Köveczes and others. The research is carried out in order to establish the following: (a) peculiarities of the actions that are in the background of the highlighted object and their semantic diffusion and, accordingly, (b) meaning categories of structures that are condensed with the form za + instrumental (qualification, temporality, spatiality, etc.), and (c) contex- tual conditioning of the understanding of these structures depending on predicate, adver- bial clauses and other sentence explicit and implied constituents. The assumption is that the broader semantics of the noun will condition the existence of a wider range of meanings of condensed units (e.g. she avoids conversations at the table: her friends find her at the table, but bent over the paper; she doesn’t like being at the stove all the time; she is at the plow all day, etc.). The question of the productivity of this structure will be shown by the semantics of nouns of recent origin in this structure (cf. he works at the loom : he is always at the computer).
PREZENT 3. L. MN. U GOVORIMA KOSOVSKOG POMORAVLJA
Authors:   University of Nis, Faculty of Philosophy, Serbia, Trajković Tatjana G.
Published: September 2024

The paper presents the status of the present form of 3rd person plural in the vernaculars of the Kosovsko Pomoravlje. An overview of the situation in the neighboring vernaculars is like- wise provided: Vranje, Bujanovac, Preševo, Gornja Pčinja, Kumanovo, Skopska Crna Gora, Gatnje, Central Kosovo, Sirinić, Prizren, Podgor and Podrima. The review was analyzed in such a way that the specificities of the vernaculars of Kosovsko Pomoravlje can be observed in relation to the nearer and more distant Prizren-South Moravian areas. It is concluded that the present form of 3rd person plural in Kosovsko Pomoravlje occupies a central place regarding the environment, for a.ll the present Prizren-South Moravian variants reflected in the observed suffixes: -v, -w, -u, -ju
Mediating Effect of Psychological Empowerment Between Perceived Organizational Support and Job Satisfaction Among Engineers in Malaysia
Authors: Lun Pok Wai , Hoo Wong Chee , Wolor Christian Wiradendi , Kimpah Jeniboy , Prompanyo Manoch
Published: September 2024

Objective: This research study aims to examine the factors influencing job satisfaction among engineers in Malaysia manufacturing industry. The factors consist of direct compensation, job security, perceived organizational support and mediating role of psychological empowerment.   Theoretical Framework: The Maslow’s hierarchy of needs and Herzberg’s two-factor theories were employed in the research and interpret the findings.   Method: A quantitative research method was employed to examine the relationships between variables through survey collected from respondents that working in various manufacturing firms across Malaysia. The study utilized a structured questionnaire distributed among 384 respondents via digital platform such as Google questionnaires. This study employed convenient sampling method to ensure representation across different manufacturing sectors. The cross-sectional approach was utilized to capture a snapshot of job satisfaction and its causes at a particular point in time, reflecting current attitudes and influences in Malaysia's manufacturing industry. The data collected will be analyzed using SPSS software for both the pilot test and data analysis. Pearson Correlation, Multiple Regression and PROCESS macro will use to examine the significant relationships between variables and hypothesized relationships.   Results and Discussion: The findings show that there are strong positive relationship between direct compensation, job security, perceived organizational support and job satisfaction among engineers. Also, psychological empowerment was revealed as a key mediator to strengthening the link between perceived organizational support and job satisfaction.   Research Implications: The results hold practical implications for organizational management and policymakers seeking to increase job satisfaction among engineers. The recommendations include fair and competitive wage structures, ensuring job security through transparent recruiting procedures, creating supportive organizational climates and empowering people to increase job satisfaction.
Procrastinación académica y comportamiento de gestión del tiempo en estudiantes universitarios: un estudio piloto
Authors: Avalos Latorre María Luisa , Ramírez Cruz José Carlos , Panduro Solórzano Jesús Alonso , Dimas Romero Kevin Diego , Salas Padilla Donovan Israel
Published: September 2024

La procrastinación se define como la tendencia a posponer o retrasar de manera voluntaria una labor evitando las responsabilidades, decisiones y tareas que requieren ser desarrolladas, resultando en un estado de insatisfacción o malestar. Esta postergación de actividades puede ser atenuada cuando no se cuentan con habilidades adecuadas de gestión del tiempo, siendo este un proceso enfocado al establecimiento y logro de metas académicas considerando el tiempo disponible. Por ello el objetivo de la presente investigación fue diseñar y pilotear una intervención educativa breve sobre la procrastinación académica y la gestión del tiempo dirigida a estudiantes universitarios. Participaron voluntariamente 25 estudiantes de la carrera de médico, cirujano y partero de primer semestre, 40% hombres y 60% mujeres, con edad promedio de 19.44 años quienes pertenecían al mismo grupo y grado. Cada uno de ellos respondió el Cuestionario de Comportamiento de Gestión del Tiempo y la Escala de Procrastinación Académica, además, participaron en una intervención educativa breve diseñada para que los estudiantes identificaran conductas de procrastinación y distintas herramientas para organización de tiempo. Los resultados indicaron que la intervención realizada tuvo una mayor influencia en las habilidades de gestión del tiempo que en la procrastinación, siendo mayormente beneficiados aquellos alumnos que trabajaban, así como las mujeres, quienes también mostraron habilidades de planeación y organización distintas a las de los hombres. Se concluye que, contar con conductas de gestión del tiempo adecuadas, no necesariamente impacta en la reducción de la procrastinación ya que posiblemente existen factores motivacionales intrínsecos y extrínsecos del ámbito escolar involucradas.
Caracterización y desafíos comerciales de los pequeños y medianos productores del municipio de Sonsón
Authors: Quintero Galeano Claudia Patricia , Rivera Martínez Cesar , Zapata Arango Diego
Published: September 2024

En Colombia, el sector rural se está viendo afectado por múltiples aspectos que limitan el desarrollo y sostenibilidad de las familias, entre ellos encontramos factores climáticos, alza en los precios de los insumos agrícolas, poca asociatividad, no existe un modelo de comercialización eficiente, ventas por medio de intermediarios, volatilidad de precios, importaciones, mal estado de las vías o inexistencia de estas, lo que dificulta la comercialización de los productos agrícolas.De acuerdo con el plan de desarrollo unidos por la vida, (Gobernación de Antioquia, 2020, p. 447) se identificó que el 74% de los alimentos consumidos en Medellín y Valle de Aburra no se producen en Antioquia, el 65% se produce en otros departamentos y un 9% por otros países. Estas cifras son preocupantes porque evidencia el gran problema que se presenta en el campo colombiano con el poco retorno económico que reciben los productores al vender sus cosechas, además identificaron que el 80% del precio de lo que paga el consumidor final corresponde a ganancias para los intermediarios en la cadena de comercializaciónCon el fin de caracterizar y conocer los procesos de comercialización y distribución de los pequeños y medianos productores del municipio de Sonsón se aplico una encuesta validada por expertos que permitió conocer que, en términos económicos, la investigación revela que, si bien los ingresos generados cubren los gastos básicos, solo algunos pueden permitirse adquirir bienes de mayor envergadura como automóviles o viviendas, evidenciando así la existencia de limitaciones económicas para la mayoría. No obstante, el 61.6% de los encuestados cultiva en predios propios, lo que podría ser un indicador de mayor rentabilidad y estabilidad financiera otro aspecto es la baja asociatividad (8.1%) entre los agricultores destaca un aspecto crucial que merece atención.
Percepciones de Ciencia, Tecnología e Innovación en la Ruralidad: Comparación de la III Encuesta Nacional con una Encuesta Piloto Realizada en una Comunidad Caficultora de Ituango
Authors: Gallardo Cabrera Cecilia , Martínez Castaño Marcela , Gómez Quintero Deisy Johana , Quirama Rivera María Alexandra , Cifuentes Posada Laura Milena
Published: September 2024

La calidad del café de Colombia es reconocida a nivel mundial, su producción requiere de una cadena extensa en la que el caficultor aplica sus conocimientos y saberes en etapas claves del proceso, como la siembra, cultivo, recolección y postcosecha, entrando en juego diferentes variables que determinan la calidad y, por consiguiente, el valor económico. La innovación aparece en la cadena del café especialmente en las etapas de comercialización generando nuevas demandas a las etapas de cosecha y postcosecha, lo que suscita la pregunta por la familiarización de los caficultores con la ciencia para responder a estas demandas. Así, el propósito de este artículo es comparar descriptivamente una encuesta de percepciones de la ciencia, tecnología e innovación puesta a prueba en una comunidad de caficultores del municipio de Ituango, con la encuesta nacional realizada en entornos urbanos, y determinar el grado de comprensión de las preguntas. Se descubre que, pese a la riqueza cultural de los territorios donde la observación y el aprendizaje son bases permanentes para responder a las exigencias del mercado de café, las palabras ciencia y tecnología no se encuentran dentro del imaginario de los caficultores tal como se encontró en la encuesta nacional, señalando, por un lado, el reto de construir cultura investigativa y poner a dialogar los saberes de los caficultores acumulados con las formas de la ciencia occidental, y, por otro lado, el reto de modificar el lenguaje de las encuestas y aplicar otras metodologías participativas para acceder a las percepciones de la ciencia y la tecnología en comunidades rurales.
The Existence of Supervision by Non-Governmental Organizations in Providing Legal Protection for Consumers with Bad Credit
Authors:   Universitas Diponegoro Semarang, Auliya Uly , Hartono Darminto ,   Universitas Diponegoro Semarang
Published: September 2024

Convoluted formal procedures have led to a crisis of public confidence in state institutions, this is what happens with bad credit, in fact the public prefers to take bad credit issues to complain to YLKI rather than going to state institutions that handle consumer protection. This research is intended to examine and analyze the role of Indonesian consumer foundations in providing protection to consumers with bad credit. The research method used is normative legal research which is carried out by conducting research, using library materials or secondary data. This research concludes, first, the problem of consumer protection for bad credit is that the public does not have confidence in resolution through consumer protection institutions under state institutions and through legal action in court as a litigation step. The reason is that complicated bureaucracy and the weak response of state institutions to the issue of bad credit have encouraged the public to choose YLKI to advocate for the issue of bad credit. Second, the existence of supervision by non-governmental organizations since 1970 has been able to respond quickly to consumer protection issues, especially regarding bad credit, namely through advocacy to save bad credit consumers who experience arbitrary collections. The problems experienced by YLKI are a lack of budget and the number of human resources that are unable to keep up with the volume of handling advocacy cases such as bad credit issues, causing YLKI to not optimally handle bad credit cases.
Assessment of Hybrid Problem Oriented Approach in teaching AETCOM module 4.9 in final MBBS curriculum
Authors: Rakholia Ritu , Maroof Mohd , Bose Pranayi
Published: September 2024

Background: AETCOM module 4.9 aims to sensitize students to legal aspects of care including negligence. It is a major public health issue related to patient safety. Aims & Objectives: This study was done to assess the effectiveness of the hybrid problem-oriented approach in teaching this module among phase 3 part-2 MBBS students and its perception among students and faculty. Methodology: Module-based educational prospective interventional study involving final MBBS students and faculty of Pediatrics Department. AETCOM Module was implemented as per NMC (National Medical Commission), India suggestions involving 1 hour of sensitization, 3 hours of self-directed learning 1 hour of role play and interactive lecture, and 1 hour of panel discussion. Pre- and post-test scores of pre-validated MCQs to assess knowledge, case closure, reflections and Likert’s scale for perception were recorded. Results: 115 final MBBS students and 6 faculty of the Department of Pediatrics participated. Significant improvement in post-test score of MCQ (mean 6.2 to 7.2 p<0.0001 on Wilcoxon signed rank test) and score on case closure (n=97, 84.3% scoring >80%) was observed. It was well received by students (n=112, 97.4%- satisfied or very satisfied) and faculty (n=5, 83.3%- very satisfied). They also found it useful (n=4, 66.7%). Majority of students strongly agreed that it enhanced understanding (n=88, 76.5%), it was practical (n=92, 80%), interesting (n=88, 76.5%), interactive (n=91, 79.1%) and promoted learning retention (n=78, 67.8%). Conclusion: A hybrid problem-based approach for teaching AETCOM module 4.9 was found to be effective in imparting knowledge and comprehension and it was well appreciated by students and faculty members.
THERMAL ADAPTIVE ARCHITECTURE: INTERPLAY BETWEEN ARCHITECTURE AND CLIMATE
Authors: Chhabra Dr Pankaj , Grover Dr Silia
Published: September 2024

The concept of architecture as a form of shelter, integral to both classical and contemporary discourse emphasizes the interplay between building structures and their climatic contexts. Vitruvius early observations underscore the importance of understanding how buildings act as barriers and responsive filters to their environments thereby shaping human activities. This paper explores the multi-faceted roles of buildings-functional, social, symbolic, artistic and their interconnections with thermal performance. While the adaptability of buildings to thermal conditions is well recognized, the impact of fluctuating economic factors such as energy prices, and the unpredictability of space usage add layers of complexity to thermal performance assessments. The research highlights the gap between theoretical knowledge and practical application in achieving optimal thermal conditions. By examining the integration of precise thermal techniques into building design this study aims to bridge these gaps and propose strategies for designing climate-sensitive architecture. The focus is on achieving comfortable and healthy living environments while ensuring cost-effective resource use. This approach advocates for a refined understanding of thermal response and its application in the design-build-occupy process ultimately contributing to more efficient and adaptive building practices.
Patent vitello-intestinal duct with a rare presentation of reverse intussusception with appendicular agenesis: A case report
Authors: Singh Aman Kumar , Gogoi Manoj , Bharadwaj Bhaswati
Published: September 2024

Background: Vitello-intestinal duct (VID) is found in approximately 2% of newborns, with patency in about 6%. Failure of obliteration leads to some anomalies, most commonly Meckel’s diverticulum. Protrusion of the small bowel is one of the rare presentations.
Case Presentation: A 10-month-old male infant presented with a prolapsed, irreducible polypoid-shaped loop of intestine protruding from the anterior abdomen. On exploratory laparotomy, patent VID was confirmed with appendicular agenesis and reverse intussusception. Gangrenous bowel was resected, followed by end-to-end ileo-ileal anastomosis, with a favorable outcome.
Conclusion: Patent VID with ileal intussusception and prolapse is a rare entity, which can be easily diagnosed clinically. A high index of suspicion is needed for any associated gut anomaly in these cases, like appendicular agenesis.
Correlation of body mass index, with cardiometabolic and cardiorespiratory fitness in health care professionals of Multan
Authors: Akhtar Esha , Khan Imran Ahmad , Perwasha Perwasha , Ishaq Shahid , Qurat-Ul-Ain  , Arshad Shumaila
Published: September 2024

The current study was conducted at Ali-Ul-Murtaza Department of  Rehabilitation  Sciences,  Muhammad  Institute  of  Medical  and  Allied  Sciences,  Multan, Pakistan, from October to December 2022  to explore the correlation of body mass index with cardiometabolic and cardiorespiratory parameters in 393 male and female healthcare professionals, including physiotherapists, pharmacists and medical laboratory technicians, aged 22-40 years. The evaluation was on the basis of the Physical Activity Readiness Questionnaire, body mass index, lipid profile, body fat and correlation of blood pressure, temperature, oxygen saturation, respiration rate and heart rate with cardiorespiratory fitness assessed through shuttle-run test, step test and treadmill test. Data was analysed using SPSS 25. Of the 393 subjects, 140(35.62) were underweight, 140(35.62) were overweight and 113(28.75) were obese. Of the total, 153(38.93) were pleased with their general health, while 240(61.06) had a history of cardiovascular and metabolic conditions.
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Effectiveness of mechanical vs. chemomechanical methods in removing intracanal calcium hydroxide medication: a randomised trial
Authors: Amir Nehal , Noor Nouman
Published: September 2024

Objective: To compare the mechanical and chemomechanical methods for removing calcium hydroxide medication from the root canal system.
Method: The triple-blind, randomised clinical trial was conducted at the Department of Operative Dentistry and Endodontics, School of Dentistry, Shaheed Zulfiqar Ali Bhutto Medical University, Islamabad, Pakistan, from December 16, 2022, to June 15, 2023, and comprised patients having necrotic teeth and chronic apical pathosis. They were randomised into groups A and B. On the initial visit, after access opening and chemomechanical preparation, calcium hydroxide paste was placed as an intracanal medication in both groups. the patients were recalled after two weeks. In Group A, calcium hydroxide was removed from the canals using a rotary master apical file, while in Group B, an endoactivator was used to sonically agitate the endodontic irrigant. Verification of placement was done by using a periapical radiograph. Data was analysed using SPSS 26.
Results: Of the 98 individuals assessed initially, 60(61.22%) were included; 34(57%) females and 26(43%) males with age ranging from 19 to 57 years. There were 27(45%) incisors, 22(36.7%) premolars and 11(18.3%) canines. There were 30(50%) patients in each of the 2 groups. The intergroup difference was not statistically significant (p=0.43). Tooth arch did not significantly correlate with the removal method (p=0.79).
Conclusion: Both methods were found to be equally effective in removing water-based calcium hydroxide medication from the endodontic system.
Clinical Trial Number: NCT05744661.
Key Words: Calcium hydroxide, Dental pulp necrosis, Microbiota, Periapical periodontitis, Root canal therapy.
Unveiling the silent struggle: navigating the labyrinth of mental health for parents of children with life-threatening illnesses in Pakistan
Authors: Faisal Seyreen , Kamran Tafiya Erum , Romaan Faisal
Published: September 2024

Dear Editor,
We write this letter to highlight the scarcely recognised complexity associated with the unrecognised mental health needs of parents of children diagnosed with life-threatening or life-limiting illnesses. It has been widely established that parents of children with disabilities are at an increased risk of developing variants of mental diseases when compared to parents of children without such disabilities. Parents tend to alter their lives socially to acclimatize themselves as caregivers for their children, therefore adopting a role that becomes far more labyrinthine as both parent and caregiver. (1) Mental health in general, is a subject that is insufficiently addressed in societal and scholarly contexts, specifically in Pakistan, particularly among parents.
Within the scope of parents acting as sole caregivers, stress is a prominent determinant contributing to their mental health. Stress can attenuate parents’ and children’s abilities to navigate these circumstances and diminish their capacity for problem-solving and coping. (2) There are a myriad of factors that contribute to the reported prevalence of mental health-related disorders among parents of children with disabilities.
Mental health remains a stigmatised entity. Such disregard impedes the delivery of healthcare towards patients suffering from mental health illnesses. There is a noteworthy hindrance in individuals facing such factors when amalgamatinge into society. When considering parental figures of diseased children, this facet serves to isolate further and reinforce such mental health illnesses. The lack of quantifiable data on anti-stigma interventions in Low and Middle-Income Countries, including Pakistan, underscores the urgent need for research. (3)
Parents of children admitted to the ICU have a near-pervasive struggle with mental health and an innate inability to disclose their requirements for support. Factors barricading such disclosure should be identified and broken down through interventions, facilitating access to vital mental health support. (4) Caregivers must establish coping strategies, and remain a steady pillar of support and comfort to their child. The Keeping Hope Alive Toolkit intervention was established, which worked on fostering emotional experiences, living in the moment, remembering self and supporting social preferences, this intervention provided a template for emotional support. (5)
We hope this letter can underscore how important supporting parental disclosure of unmet mental health needs is – a rampant and insufficiently reported plight in Pakistan. The ability to recognise these emotions and rectify them is not highlighted in this region but is imperative to implement, to improve the provision of healthcare to diseased children and their parents alike.