bluuebunny/crossref_metadata_2025 huggingface dataset:
Composition, Clinical Efficiency, and Mechanism of NHC-Approved “Three Chinese Medicines and Three Chinese Recipes” for COVID-19 Treatment
Authors: Xia Ke-Yao , Zhao Zeyuan , Shah Taif , Wang Jing-Yi , Baloch Zulqarnain
Published: February 2022

Traditional Chinese medicines (TCMs) have been regularly prescribed to treat and prevent diseases for thousands of years in the eastern part of the Asian continent. Thus, when the coronavirus disease 2019 (COVID-19) epidemic started, TCM was officially incorporated as a strategy by the National Health Commission (NHC) for the treatment of COVID-19 infection. TCMs were used to treat COVID-19 and had a significant effect on alleviating symptoms, delaying disease progression, improving the cure rate, and reducing the mortality rate in China. Therefore, China’s National Health Commission officially approved Qingfei Paidu decoction, Xuanfei Baidu decoction, Huashi Baidu decoction, Lianhua Qingwen capsules, Jinhua Qinggan granules, and Xuebijing for COVID-19 treatment. This review evaluates and summarizes the use of TCMs against infectious diseases and the composition, clinical efficacy, and mechanisms of the NHC-approved “three Chinese medicines and three Chinese recipes” for COVID-19 treatment. The three Chinese medicines and three Chinese recipes have been demonstrated to be highly effective against COVID-19, but there is a lack of in vivo or in vitro evidence. Most of the available data related to the potential mechanism of the three Chinese medicines and three Chinese recipes is based on virtual simulation or prediction, which is acquired via molecular docking and network pharmacology analysis. These predictions have not yet been proven. Therefore, there is a need for high-quality in vivo and in vitro and clinical studies by employing new strategies and technologies such as genomics, metabolomics, and proteomics to verify the predicted mechanisms of these drug’s effects on COVID-19.
Bupleuri radix for Acute Uncomplicated Respiratory Tract Infection: A Systematic Review of Randomized Controlled Trials
Authors: Yan Li-Jiao , Wang Zhi-Jie , Fang Min , Lan Hui-Di , Moore Michael , Willcox Merlin , Trill Jeanne , Hu Xiao-Yang , Liu Jian-Ping
Published: February 2022

Objective: To evaluate the efficacy, clinical effectiveness, and safety of the Chinese herb Bupleuri radix for the treatment of acute uncomplicated respiratory tract infections (ARTIs).

Methods: Four English and four Chinese databases were searched from their inception to June 2021. Randomized controlled trials (RCTs) assessing therapeutic effects of Bupleuri radix on ARTI were eligible for inclusion. The risk of bias for each trial was assessed using the Cochrane Risk of Bias Tool 2.0. RevMan 5.4 software was used for data analyses with effects estimated as risk ratios (RR) or mean differences (MD) with 95% confidence intervals (CI). The certainty of the evidence was assessed using the online GRADEpro tool.

Results: Seven randomized trials involving 910 patients with acute upper respiratory tract infection (AURTI) were included. The review identified Bupleuri radix agents with four administration routes (oral, acupoint injection, intramuscular injection, nebulized inhalation). Bupleuri radix acupoint injection compared with placebo showed statistically significant effects in reducing fever resolution time (MD: −33.32 h, 95%CI: −35.71, −30.93), and in increasing the proportion of participants with fever resolved within 48 h from treatment onset (RR: 14, 95%CI: 1.96, 99.94). Bupleuri radix acupoint injection combined with usual care is more effective in reducing the temperature at day 1 from treatment onset (MD: −1.00°C, 95%CI: −1.19, −0.81) compared with usual care alone. Bupleuri radix pills showed similar antipyretic effects to acetaminophen. However, Bupleuri radix intramuscular injection plus vitamins failed to demonstrate an effect in reducing fever, when compared with ribavirin plus vitamins. It suggested that oral administration of Bupleuri radix solution for injections, pills, and Bupleuri radix decoction have a similar effect on improving global AURTI symptoms including two key symptoms (nasal discharge and cough), when compared with usual care alone. Only two trials reported whether or not there were any AEs and found no occurrence of adverse events in the herbal group.

Conclusion: Low-certainty or very low-certainty evidence demonstrated that Bupleuri radix (solution for injections and pills) has an antipyretic effect on febrile patients with AURTI, but it has no effect on other AURTI symptoms. However, these findings need to be further confirmed by well-designed clinical trials with adequate sample sizes.

Systematic review registration: (https://www.crd.york.ac.uk/prospero/#recordDetails), PROSPERO registration number: CRD42021234066.
The Dynamic Role of Microglia and the Endocannabinoid System in Neuroinflammation
Authors: Young Alexander P. , Denovan-Wright Eileen M.
Published: February 2022

Microglia, the resident immune cells of the brain, can take on a range of pro- or anti-inflammatory phenotypes to maintain homeostasis. However, the sustained activation of pro-inflammatory microglia can lead to a state of chronic neuroinflammation characterized by high concentrations of neurotoxic soluble factors throughout the brain. In healthy brains, the inflammatory processes cease and microglia transition to an anti-inflammatory phenotype, but failure to halt the pro-inflammatory processes is a characteristic of many neurological disorders. The endocannabinoid system has been identified as a promising therapeutic target for chronic neuroinflammation as there is evidence that synthetic and endogenously produced cannabinoids temper the pro-inflammatory response of microglia and may encourage a switch to an anti-inflammatory phenotype. Activation of cannabinoid type 2 (CB2) receptors has been proposed as the mechanism of action responsible for these effects. The abundance of components of the endocannabinoid system in microglia also change dynamically in response to several brain pathologies. This can impact the ability of microglia to synthesize and degrade endocannabinoids or react to endogenous and exogenous cannabinoids. Cannabinoid receptors also participate in the formation of receptor heteromers which influences their function specifically in cells that express both receptors, such as microglia. This creates opportunities for drug-drug interactions between CB2 receptor-targeted therapies and other classes of drugs. In this article, we review the roles of pro- and anti-inflammatory microglia in the development and resolution of neuroinflammation. We also discuss the fluctuations observed in the components of the endocannabinoid in microglia and examine the potential of CB2 receptors as a therapeutic target in this context.
Evaluation of Prescription Medication Sharing Among Adults in South Korea: A Cross-Sectional Survey
Authors: Song Seulki , Kim Seungyeon , Shin Sangyoon , Lee Young , Lee Euni
Published: February 2022

Background: Prescription medication sharing is an inappropriate medication use behavior that can lead to medication errors and adverse drug events, posing a public health threat. The reported prevalence of prescription medication lending and borrowing varies by country, ranging from 6%–23% and 5%–52%, respectively. However, research on medication sharing is scant in Asian countries. Therefore, this study aimed to describe the rate of prescription medication sharing practices and investigate the associated behavioral factors, types of shared medications, and reasons for sharing among adults in South Korea.

Methods: A cross-sectional study was conducted using an online self-administered survey of 1,000 adults (aged 19–69 years; November 2020). A stratified sampling method was used to select survey participants from a nationwide consumer panel, which ensured a representative distribution of the Korean population by age, gender, and region. Descriptive and logistic regression analyses were used to evaluate the information related to sharing behavior.

Results: A total of 1,000 respondents participated in this study. The mean age of the respondents was 44.7 years (standard deviation [SD], 13.4), ranging from 20 to 69 years. The rate of medication sharing was 52.4%. The most prevalently shared medications were analgesic, antipyretic, and antimigraine medications. Prescription medications were shared mostly between family and relatives. Older age was a predictive factor for sharing analgesics. Lower educational level was a predictive factor for sharing ophthalmic medications.

Conclusions: Approximately one in two respondents in our study have experienced medication sharing in their lifetime. Future studies are needed to establish evidence-based strategies for patient education and improve the medication use process. Healthcare professionals should assess patients’ needs for accessing medications and be ready to educate and guide them with specific action plans. Policymakers should consider patient empowerment strategies including public education and campaigns to avoid potential adverse outcomes of medication sharing.
Efficacy and Safety of Shenqu Xiaoshi Oral Liquid Compared With Domperidone Syrup in Children With Functional Dyspepsia
Authors: Yu Yi , Xie Xiao-Li , Wu Jie , Li Zhong-Yue , He Zhi-Gang , Liang Chun-Jie , Jin Zhong-Qin , Wang Ai-Zhen , Gu Jian , Huang Ying , Mei Hong , Shi Wei , Hu Si-Yuan , Jiang Xun , Du Juan , Hu Chi-Jun , Gu Li , Jiang Mao-Lin , Mao Zhi-Qin , Xu Chun-Di
Published: February 2022

Background: Treatment of functional dyspepsia (FD) in children is generally symptomatic and unsatisfactory. Traditional Chinese medicines, such as Shenqu Xiaoshi Oral Liquid (SXOL), have been recommended to alleviate dyspeptic symptoms. However, evidence of their safety and efficacy remains limited to date. AIM: To assess whether 2 weeks of therapy with SXOL was non-inferior to domperidone syrup in children with FD.

Methods: In this randomized, double-blind, double-simulated, non-inferiority, multi-center clinical trial, we recruited children (3–14 years) with FD according to the Rome IV criteria from 17 tertiary medical centers across China. Patients were randomly allocated (1:1) to receive SXOL or domperidone syrup for 2 weeks. We compared the participants’ clinical scores from both groups based on the severity and frequency of dyspepsia symptoms according to Rome IV criteria (0, 1, 2, and 4 weeks after randomization). The primary endpoint was the total response rate, which was defined as the proportion of patients with a decrease of 30% or more in the FD symptoms clinical score from baseline, at the end of the 2-weeks treatment. A non-inferiority margin of -10% was set. Secondary endpoints and adverse events were assessed. This trial is registered with www.Chictr.org.cn, number ChiCTR1900022654.

Results: Between February 2019 and March 2021, a total of 373 patients were assessed for eligibility, and 356 patients were enrolled and randomized. The clinical response rate at week two was similar for SXOL [118 (83.10%) of 142] and domperidone [128 (81.01%) of 158]; difference 2.09; 95% CI −6.74 to 10.71, thereby establishing non-inferiority. The total FD symptom scores were significantly improved in the two groups at 1-, 2-, and 4-weeks follow-up periods (p < 0.005). The decrease in symptom score compared with the baseline were similar between these two groups. Over the total study period, 10 patients experienced at least one treatment-related adverse event [six (3.37%)] in the SXOL group, four [(2.25%) in the domperidone group], although no serious adverse event was noted.

Conclusion: Treatment with SXOL effectively improves dyspeptic symptoms and is well tolerated. In addition, it is not inferior to domperidone syrup and leads to sustained improvement in Chinese children with FD.
Static and Dynamic Measurements of Compliance and Driving Pressure: A Pilot Study
Authors: Tawfik Pierre , Syed Muhammad K. Hayat , Elmufdi Firas S. , Evans Michael D. , Dries David J. , Marini John J.
Published: February 2022

Rationale

Monitoring tidal cycle mechanics is key to lung protection. For this purpose, compliance and driving pressure of the respiratory system are often measured clinically using the plateau pressure, obtained after imposing an extended end-inspiratory pause, which allows for relaxation of the respiratory system and redistribution of inflation volume (method A). Alternative methods for estimating compliance and driving pressure utilize the measured pressure at the earliest instance of zero flow (method B), the inspiratory slope of the pressure-time tracing during inflation with constant flow (method C), and the expiratory time constant (method D).

Methods

Ten passive mechanically ventilated subjects, at a large tertiary referral center, underwent measurements of compliance and driving pressure using the four different methods. The inspiratory tidal volume, inspiratory to expiratory ratio, and positive end expiratory pressures were then adjusted from baseline and the measurements re-obtained.

Results

Method A yielded consistently higher compliance and lower driving pressure calculations compared to methods B and C. Methods B and C most closely approximated one another. Method D did not yield a consistent reliable pattern.

Conclusion

Static measurements of compliance and driving pressure using the plateau pressure may underestimate the maximum pressure experienced by the most vulnerable lung units during dynamic inflation. Utilizing the pressure at zero flow as a static measurement, or the inspiratory slope as a dynamic measurement, may calculate a truer estimate of the maximum alveolar pressure that generates stress upon compromised lung units.
Chronic, Combined Cardiac and Renal Dysfunction Exacerbates Renal Venous Pressure-Induced Suppression of Renal Function in Rats
Authors: Hamza Shereen M. , Huang Xiaohua , Zehra Tayyaba , Zhuang Wenqing , Cupples William A. , Braam Branko
Published: February 2022

Background and Objective

Increased renal venous pressure (RVP) is common in combined heart and kidney failure. We previously showed that acute RVP elevation depresses renal blood flow (RBF), glomerular filtration rate (GFR), and induces renal vasoconstriction in the absence of changes in blood pressure in healthy rats. We used our established rodent model of chronic combined heart and kidney failure (H/KF) to test whether RVP elevation would impair cardiovascular stability, renal perfusion and exacerbate renal dysfunction.

Methods

Male rats were subjected to 5/6 nephrectomy (SNx or Sham) and 6% high salt diet followed 7 weeks later by ligation of the left anterior descending coronary artery (CL or Sham). Experimental groups: CL + SNx (n = 12), Sham CL + SNx (n = 9), CL+ Sham SNx (n = 6), and Sham Control (n = 6). Six weeks later, anesthetized rats were subjected to an acute experiment whereupon mean arterial pressure (MAP), heart rate (HR), RVP, RBF, and GFR were measured at baseline and during elevation of RVP to 20–25 mmHg for 120 min.

Results

Baseline MAP, HR, RBF, and renal vascular conductance (RVC) were comparable among groups. Baseline GFR was significantly depressed in CL + SNx and Sham CL + SNx groups compared to Sham Control and CL + Sham SNx groups. Upon RVP increase, MAP and HR fell in all groups. Increased RVP exacerbated the reduction in RBF in CL + SNx (−6.4 ± 0.9 ml/min) compared to Sham Control (−3.7 ± 0.9 ml/min, p < 0.05) with intermediate responses in Sham CL + SNx (−6.8 ± 1.3 ml/min) and CL + Sham SNx (−5.1 ± 0.4 ml/min) groups. RVP increase virtually eliminated GFR in CL + SNx (−99 ± 1%), Sham CL + SNx (−95 ± 5%), and CL + Sham SNx (−100%) groups compared to Sham Control (−84 ± 15% from baseline; p < 0.05). Renal vascular conductance dropped significantly upon RVP increase in rats with HF (CL + SNx: −0.035 ± 0.011; CL + Sham SNx: −0.050 ± 0.005 ml/min·mmHg−1, p < 0.05) but not Sham CL + SNx (−0.001 ± 0.019 ml/min·mmHg−1) or Control (−0.033 ± mL/min·mmHg−1).

Conclusion

Chronic combined heart and kidney failure primarily impairs renal hemodynamic stability in response to elevated RVP compared to healthy rats.
Comparison of Leaf and Fine Root Traits Between Annuals and Perennials, Implicating the Mechanism of Species Changes in Desertified Grasslands
Authors: Ning Zhiying , Li Yulin , Zhao Xueyong , Han Dan , Zhan Jin
Published: February 2022

Annual species show traits, such as shortleaf lifetimes, higher specific leaf area, and leaf nutrient concentrations, that provided a more rapid resource acquisition compared to perennials. However, the comparison of root traits between the annuals and perennials is extremely limited, as well as the trade-offs of leaf and fine root traits, and resource allocation between leaf and root, which may provide insight into the mechanism of species changes in arid and semi-arid areas. With lab analysis and field observation, 12 traits of leaf and fine root of 54 dominant species from Horqin Sandy Land, Northeastern China were measured. The organization of leaf and fine root traits, and coordination between leaf and fine root traits of annual and perennial plants were examined. Results showed that there were differences between annuals and perennials in several leaves and fine root traits important in resource acquisition and conservation. Annuals had higher leaf area (LA), specific LA (SLA), and specific root length (SRL) but lower leaf dry-matter content (LDMC), leaf tissue density (LTD), leaf carbon concentration (LC), and fine root dry-matter content (FRDMC) than perennials. Leaf nitrogen (LN) concentration and fine root nitrogen concentration (FRN) were negatively related to LTD and FRDMC in annuals, while FRN was positively related to FRTD and fine root carbon concentration (FRC), and LA was positively related to LN in perennials. These implied that annuals exhibited tough tissue and low palatability, but perennials tend to have smaller leaves to reduce metabolism when N is insufficient. Annuals showed significant positive correlations between FRC/FRDMC and LDMC/LTD/LC, suggesting a proportional allocation of photosynthate between leaf and fine root. In perennials, significant negative correlations were detected between LN, LC, and SRL, fine root tissue density (FRTD), as well as between LA and FRTD/FRC. These indicated that perennials tend to allocate more photosynthate to construct a deeper and rigid roots system to improve resource absorption capacity in resource-limited habitats. Our findings suggested that annuals and perennials differed considerably in terms of adaptation, resource acquisition, and allocation strategies, which might be partly responsible for species changes in desertified grasslands. More broadly, this work might be conducive to understand the mechanism of species changes and could also provide support to the management and restoration of desertified grassland in arid and semi-arid areas.
Mung Bean (Vigna radiata L.) Source Leaf Adaptation to Shading Stress Affects Not Only Photosynthetic Physiology Metabolism but Also Control of Key Gene Expression
Authors: Gong Xiangwei , Liu Chunjuan , Dang Ke , Wang Honglu , Du Wanli , Qi Hua , Jiang Ying , Feng Baili
Published: February 2022

Shading stress strongly limits the effective growth of plants. Understanding how plant morphogenesis and physiological adaptation are generated in response to the reduced low light conditions is important for food crop development. In this study, two mung bean (Vigna radiata L.) cultivars, namely, Xilv 1 and Yulv 1, were grown in the field to explore the effects of shading stress on their growth. The results of morphology, physiology, and biochemistry analyses showed that the shading stress significantly weakened the leaf photosynthetic capacity as measured by the decreased net photosynthetic rate, stomatal conductance, and transpiration rate and increased intercellular CO2 concentration. These responses resulted in plant morphological characteristics that increased the light energy absorption in low light conditions. Such variations occurred due to the leaf anatomical structure with destroyed palisade tissues and spongy tissues. Under shading stress, Yulv 1 showed higher physiological metabolic intensity than Xilv 1, which was related to changes in chlorophyll (Chl), such as Chl a and b, and Chl a/b ratio. Compared with normal light conditions, the Chl fluorescence values, photosynthetic assimilation substances, and enzyme activities in mung bean plants under shading stress were reduced to different extent. In addition, the relative expression levels of VrGA2ox, VrGA20ox1, VrGA3ox1, VrROT3, and VrBZR1, which are related to endogenous hormone in mung bean leaves, were upregulated by shading stress, further leading to the improvements in the concentrations of auxin, gibberellins (GAs), and brassinolide (BR). Combined with the morphological, physiological, and molecular responses, Yulv 1 has stronger tolerance and ecological adaptability to shading stress than Xilv 1. Therefore, our study provides insights into the agronomic traits and gene expressions of mung bean cultivars to enhance their adaptability to the shading stress.
Quantitative Trait Locus Mapping for Resistance Against Pyrenopeziza brassicae Derived From a Brassica napus Secondary Gene Pool
Authors: Karandeni Dewage Chinthani S. , Cools Katherine , Stotz Henrik U. , Qi Aiming , Huang Yong-Ju , Wells Rachel , Fitt Bruce D. L.
Published: February 2022

Use of host resistance is the most economical and environmentally safe way to control light leaf spot disease of oilseed rape (Brassica napus). The causal organism of light leaf spot, Pyrenopeziza brassicae, is one of the most economically damaging pathogens of oilseed rape in the United Kingdom and it is considered to have a high potential to evolve due to its mixed reproduction system and airborne ascospores. This necessitates diverse sources of host resistance, which are inadequate at present to minimize yield losses caused by this disease. To address this, we screened a doubled haploid (DH) population of oilseed rape, derived from a secondary gene pool (ancestral genomes) of B. napus for the introgression of resistance against P. brassicae. DH lines were phenotyped using controlled-environment and glasshouse experiments with P. brassicae populations obtained from three different geographic locations in the United Kingdom. Selected DH lines with different levels of resistance were further studied in a controlled-environment experiment using both visual (scanning electron microscope – SEM) and molecular (quantitative PCR) assessment methods to understand the mode/s of host resistance. There was a clear phenotypic variation for resistance against P. brassicae in this DH population. Quantitative trait locus (QTL) analysis identified four QTLs with moderate to large effects, which were located on linkage groups C1, C6, and C9. Of these, the QTL on the linkage group C1 appeared to have a major effect on limiting P. brassicae asexual sporulation. Study of the sub-cuticular growth phase of P. brassicae using qPCR and SEM showed that the pathogen was able to infect and colonise both resistant and susceptible Q DH lines and control B. napus cultivars. However, the rate of increase of pathogen biomass was significantly smaller in resistant lines, suggesting that the resistance segregating in this DH population limits colonisation/sporulation by the pathogen rather than eliminating the pathogen. Resistance QTLs identified in this study provide a useful resource for breeding cultivar resistance for effective control of light leaf spot and form a starting point for functional identification of the genes controlling resistance against P. brassicae that can contribute to our knowledge on mechanisms of partial resistance of crops against pathogens.
People-Powered and Non-Violent Social Movements: Forcing Gradualist Democratic Reforms in Authoritarian Societies
Authors: Zunes Stephen
Published: February 2022

Not all successful unarmed civil insurrections against dictatorships take place in a dramatic mass uprising with hundreds of thousands occupying central squares in the capital city. There have also been cases of nonviolent struggles against autocratic regimes that failed to topple the dictatorship in a revolutionary wave, but did succeed in forcing a series of legal, constitutional and institutional reforms over a period of several years that eventually evolved into a liberal democratic order. These more gradualist transitions have taken place across different regions and against different kinds of authoritarian systems. This webinar will tell the story of pro-democracy movements in three of these countries—Brazil, South Korea and Kenya—and how they were able to force, over time, autocratic governments to agree to substantive democratic reforms. By focusing on the role of civil society, this presentation challenges dominant, top-down, institution- and elite-based approaches to democratization.
The Relationships of Parental Responsiveness, Teaching Responsiveness, and Creativity: The Mediating Role of Creative Self-Efficacy
Authors: Zhang Yanna , Li Pin , Zhang Zhitian Skylor , Zhang Xingli , Shi Jiannong
Published: February 2022

This study investigated the relationships between parental responsiveness, teaching responsiveness, and creativity, as well as the mechanism underlying these associations. We collected data from 584 Chinese college students via convenience sampling method and used self-report scales to measure their perceived parental responsiveness, teaching responsiveness, creative self-efficacy, and creativity. We employed structural equation modeling (SEM) to examine the relationships among these variables and the mediation effect. The results revealed that both parental responsiveness and teaching responsiveness were positively related to student creativity. Moreover, creative self-efficacy mediated the relationships of parental responsiveness, teaching responsiveness, and creativity. The findings highlight the significance of responsiveness from parents and teachers on student creativity and verify the potential mediating role of creative self-efficacy. These findings suggest that teachers and parents can foster creativity by providing warm and supportive responses to students’ creative needs.
Shorebirds’ Longer Migratory Distances Are Associated With Larger ADCYAP1 Microsatellites and Greater Morphological Complexity of Hippocampal Astrocytes
Authors: de Almeida Miranda Diego , Araripe Juliana , de Morais Magalhães Nara G. , de Siqueira Lucas Silva , de Abreu Cintya Castro , Pereira Patrick Douglas Corrêa , Henrique Ediely Pereira , da Silva Chira Pedro Arthur Campos , de Melo Mauro A. D. , do Rêgo Péricles Sena , Diniz Daniel Guerreiro , Sherry David Francis , Diniz Cristovam W. P. , Guerreiro-Diniz Cristovam
Published: February 2022

For the epic journey of autumn migration, long-distance migratory birds use innate and learned information and follow strict schedules imposed by genetic and epigenetic mechanisms, the details of which remain largely unknown. In addition, bird migration requires integrated action of different multisensory systems for learning and memory, and the hippocampus appears to be the integration center for this task. In previous studies we found that contrasting long-distance migratory flights differentially affected the morphological complexity of two types of hippocampus astrocytes. Recently, a significant association was found between the latitude of the reproductive site and the size of the ADCYAP1 allele in long distance migratory birds. We tested for correlations between astrocyte morphological complexity, migratory distances, and size of the ADCYAP1 allele in three long-distance migrant species of shorebird and one non-migrant. Significant differences among species were found in the number and morphological complexity of the astrocytes, as well as in the size of the microsatellites of the ADCYAP1 gene. We found significant associations between the size of the ADCYAP1 microsatellites, the migratory distances, and the degree of morphological complexity of the astrocytes. We suggest that associations between astrocyte number and morphological complexity, ADCYAP1 microsatellite size, and migratory behavior may be part of the adaptive response to the migratory process of shorebirds.
Treatments for Female Victims of Intimate Partner Violence: Systematic Review and Meta-Analysis
Authors: Karakurt Günnur , Koç Esin , Katta Pranaya , Jones Nicole , Bolen Shari D.
Published: February 2022

Intimate partner violence (IPV) is an important problem that has significant detrimental effects on the wellbeing of female victims. The chronic physical and psychological effects of intimate partner violence (IPV) are complex, long-lasting, chronic, and require treatments focusing on improving mental health issues, safety, and support. Various psycho-social intervention programs are being implemented to improve survivor wellbeing. However, little is known about the effectiveness of different treatments on IPV survivors' wellbeing. For this purpose, we conducted a systematic review and meta-analysis to assess the effectiveness of interventions on improving outcomes that describe the wellbeing of adult female survivors of IPV. We searched PubMed, PsycINFO, and Cochrane Library. We explored the effectiveness of available interventions on multiple outcomes that are critical for the wellbeing of adult female victims of IPV. To provide a broad and comprehensive view of survivors' wellbeing, we considered outcomes including mental health, physical health, diminishing further violence, social support, safety, self-efficacy, and quality of life. We reviewed 2,770 citations. Among these 25 randomized-controlled-study with a total of 4,683 participants met inclusion criteria. Findings of meta-analyses on interventions indicated promising results in improving anxiety [standardized mean difference (SMD) −7.15, 95% confidence interval (CI) −8.39 to −5.92], depression (SMD −0.26, CI −0.56 to −0.05), safety (SMD = 0.43, CI 0.4 to −0.83), violence prevention (SMD = −0.92, CI −1.66 to −0.17), health (SMD = 0.39, CI 0.12 to 0.66), self-esteem (SMD = 1.33, CI −0.73 to 3.39), social support (SMD =0.40, CI 0.20 to 0.61), and stress management (SMD = −8.94, CI −10.48 to −7.40) at the post-test. We found that empowerment plays a vital role, especially when treating depression and Post-Traumatic Stress Disorder (PTSD), which are difficult to improve across interventions. We found mixed findings on self-efficacy and quality of life. The effects of IPV are long-lasting and require treatments targeting co-morbid issues including improving safety and mental health issues.
Trauma Exposure and Prolonged Grief Disorder Among Persons Receiving Community Mental Health Services: Rates and Correlates
Authors: Lu Weili , Yanos Philip T. , Waynor William R. , Gao Carol E. , Bazan Carolyn , Giacobbe Giovanna , Gill Kenneth , Bullock Deanna , Prigerson Holly G.
Published: February 2022

Background

Persons with serious mental illnesses (SMIs) are at increased risk for exposure to trauma and posttraumatic stress disorder (PTSD). Prolonged Grief Disorder (PGD) may also impact this population but has been seldom studied.

Aims

The present study investigated the rate of both PTSD and PGD among clients receiving community mental health services, and the clinical correlates of co-occurring PTSD/PGD.

Methods

Trauma history, PTSD and PGD were assessed among 536 individuals receiving community mental health services (Study 1). A subsample of 127 individuals from Study 1 who met DSM-5 criteria for PTSD based on diagnostic interview completed measures of psychiatric symptoms (Study 2).

Results

In Study 1, 92.4% of participants receiving community mental health services had experienced a traumatic event, 49.6% met criteria for probable and provisional PTSD, 14.7% scored positive for probable PGD, and 11.9% met criteria for probable and provisional PTSD as well as probable PGD. In Study 2, participants meeting diagnostic DSM-5 criteria for PTSD and probable PGD had more self-reported PTSD symptoms, but did not differ on other outcomes.

Conclusions

Findings highlight the need for trauma informed services including grief counseling for persons with SMI.
Scaling Evidence-Based Interventions to Improve the Cardiovascular Health of People With Serious Mental Illness
Authors: Yuan Christina T. , McGinty Emma E. , Dalcin Arlene , Goldsholl Stacy , Dickerson Faith , Gudzune Kimberly A. , Jerome Gerald J. , Thompson David A. , Murphy Karly A. , Minahan Eva , Daumit Gail L.
Published: February 2022

People with serious mental illnesses (SMIs) experience excess mortality, driven in large part by high rates of cardiovascular disease (CVD), with all cardiovascular disease risk factors elevated. Interventions designed to improve the cardiovascular health of people with SMI have been shown to lead to clinically significant improvements in clinical trials; however, the uptake of these interventions into real-life clinical settings remains limited. Implementation strategies, which constitute the “how to” component of changing healthcare practice, are critical to supporting the scale-up of evidence-based interventions that can improve the cardiovascular health of people with SMI. And yet, implementation strategies are often poorly described and rarely justified theoretically in the literature, limiting the ability of researchers and practitioners to tease apart why, what, how, and when implementation strategies lead to improvement. In this Perspective, we describe the implementation strategies that the Johns Hopkins ALACRITY Center for Health and Longevity in Mental Illness is using to scale-up three evidenced-based interventions related to: (1) weight loss; (2) tobacco smoking cessation treatment; and (3) hypertension, dyslipidemia, and diabetes care for people with SMI. Building on concepts from the literature on complex health interventions, we focus on considerations related to the core function of an intervention (i.e., or basic purposes of the change process that the health intervention seeks to facilitate) vs. the form (i.e., implementation strategies or specific activities taken to carry out core functions that are customized to local contexts). By clearly delineating how implementation strategies are operationalized to support the interventions' core functions across these three studies, we aim to build and improve the future evidence base of how to adapt, implement, and evaluate interventions to improve the cardiovascular health of people with SMI.
Association Between Mental Health Outcomes and Changes in Lifestyle Behavior Index Among Saudi Adults 16 Weeks After COVID-19 Pandemic Lockdown Release
Authors: Abd El-Fatah Nesrin Kamal , Alshehri Abdalsalam Abdullah , Alsulami Fatma H. , Alasmari Norah , Osman Nermin A.
Published: February 2022

Background

The current (coronavirus disease 2019 [COVID-19]) pandemic is still uncontrolled with associated dramatic changes in daily lifestyle activities. Evidence for studying the impact of these health behavior changes on our mental health is limited. Therefore, this study aimed to estimate the prevalence of psychological distresses and assess their influence by the change in the composite lifestyle behaviors before the COVID-19 pandemic till 16 weeks after the lockdown release in Saudi Arabia.

Methods

This cross-sectional study was conducted between October 10 and 31, 2020 by posting an online survey on social media platforms (WhatsApp and Twitter) to collect data on participants' sociodemographic, lifestyle behaviors, and mental health aspects using a validated Arabic version of the short-form version of the Depression Anxiety Stress Scales-21 (DASS-21).

Results

A total of 363 responded to the questionnaire. The mean age was 36.26 ± 8.54 years, and 238 (65.6%) were men. Depression, stress, and anxiety were reported in 37.5, 26.7, and 16.5% of the participants, respectively. Negative lifestyle behavioral changes were significantly associated with stress and anxiety (p < 0.05). Logistic regression revealed that financial distress and history of psychiatric illnesses were common significant factors for developing the psychological distresses.

Conclusion

Throughout the post-lockdown stage of the COVID-19 outbreak in Saudi Arabia, there was an evidence of psychological distresses among the adults. Negative health-related changes are directly linked with increased psychological distress. Effective health promotion strategies directed toward adopting and maintaining positive change in the composite health behaviors are crucial.
Developmental Assets, Self-Control and Internet Gaming Disorder in Adolescence: Testing a Moderated Mediation Model in a Longitudinal Study
Authors: Xiang Guo-Xing , Gan Xiong , Jin Xin , Zhang Yan-Hong , Zhu Cong-Shu
Published: February 2022

From the perspective of positive youth development, developmental assets and self-control play critical roles in promoting adolescent development. However, their effects have not been evaluated in the current issue, internet gaming disorder (IGD). IGD is gradually becoming an important social problem among worldwide youth and has been included in the eleventh International Classification of Diseases (ICD-11). Therefore, the present study was determined to investigate the relationship between developmental assets, self-control, and IGD. A two-wave longitudinal study, with each wave spanning half a year apart, was conducted in a sample of 1023 adolescents (aging from 11 to 15, 49.36% boys) during the COVID-19 pandemic. Results of the moderated mediation model revealed that T1 developmental assets could predict less IGD at T2 directly or through T1 self-control indirectly. Furthermore, the moderating effect of gender was not significant in the mediation model. Overall, adolescents who experience more developmental assets are less likely to suffer IGD. Moreover, developmental assets are conducive to developing a higher level of self-control, which in turn contributes to preventing or intervening in IGD as well. Therefore, measures should be taken to construct developmental assets to prevent or reduce IGD during adolescence.
The Vaccine Communication Demands on Community-Based Workforces
Authors: Rauh Lauren , Patry Dave , Zambrano Michelle , Lathan Hannah Stuart , Tavarez Emilio , El-Mohandes Ayman
Published: February 2022

Community-based organizations (CBOs) are experiencing some of the highest demand in years for a wide spectrum of health and social services. Their client-facing employees have taken on a new, challenging role as a sought-after source of COVID-19 vaccine information and guidance. These workforces operating on the frontlines, do their best to meet the increased need for services and information, often without additional resources or training to do so. The most effective immediate response to this challenge is a comprehensive communication support system working in tandem with CBOs. Our three organizations, the New York Vaccine Literacy Campaign at the CUNY Graduate School of Public Health and Health Policy, Hunger Free NYC, and Health Leads, have collaborated in key short-term approaches to meet these needs. We outline these processes and anticipated outcomes and offer lessons learned to advocate for long-term structural changes needed to increase community-level communication support.
Virtual Reality Medical Training for COVID-19 Swab Testing and Proper Handling of Personal Protective Equipment: Development and Usability
Authors: Zikas Paul , Kateros Steve , Lydatakis Nick , Kentros Mike , Geronikolakis Efstratios , Kamarianakis Manos , Evangelou Giannis , Kartsonaki Ioanna , Apostolou Achilles , Birrenbach Tanja , Exadaktylos Aristomenis K. , Sauter Thomas C. , Papapagiannakis George
Published: February 2022

Efficient and riskless training of healthcare professionals is imperative as the battle against the Covid-19 pandemic still rages. Recent advances in the field of Virtual Reality (VR), both in software and hardware level, unlocked the true potential of VR medical education (Hooper et al., The Journal of Arthroplasty, 2019, 34 (10), 2,278–2,283; Almarzooq et al., Virtual learning during the COVID-19 pandemic: a disruptive technology in graduate medical education, 2020; Wayne et al., Medical education in the time of COVID-19, 2020; Birrenbach et al., JMIR Serious Games, 2021, 9 (4), e29586). The main objective of this work is to describe the algorithms, models and architecture of a medical virtual reality simulation aiming to train medical personnel and volunteers in properly performing Covid-19 swab testing and using protective measures, based on a world-standard hygiene protocol. The learning procedure is carried out in a novel and gamified way that facilitates skill transfer from virtual to real world, with performance that matches and even exceeds traditional methods, as shown in detail in (Birrenbach et al., JMIR Serious Games, 2021, 9 (4), e29586). In this work we are providing all computational science methods, models together with the necessary algorithms and architecture to realize this ambitions and complex task verified via an in-depth usability study with year 3–6 medical school students.
Variations in Nutritional Requirements Across Bee Species
Authors: Barraud Alexandre , Barascou Lena , Lefebvre Victor , Sene Deborah , Le Conte Yves , Alaux Cedric , Grillenzoni Francesca-Vittoria , Corvucci Francesca , Serra Giorgia , Costa Cecilia , Vanderplanck Maryse , Michez Denis
Published: February 2022

With 2,000 species currently recorded in Europe, bees are a highly diversified and efficient group of pollinating insects. They obtain their nutrients from nectar and pollen of flowers. However, the chemical composition of these resources, especially of pollen (e.g., protein, lipid, amino acids, fatty acids, or sterol content), is highly variable among plant species. While it is well-known that bees show interspecific variation in their floral choices, there is a lack of information on the nutritional requirements of different bee species. We therefore developed original experiments in laboratory conditions to evaluate the interspecific variations in bee nutritional requirements. We analyzed the chemical content of eight pollen blends, different in terms of protein, lipid, amino acids, and sterols total concentration and profiles. Each pollen blend was provided to four different bee model species: honey bees (Apis mellifera), bumblebees (Bombus terrestris), mason bees (Osmia bicornisandOsmia cornuta). For each species, specific protocols were used to monitor their development (e.g., weight, timing, survival) and resource collection. Overall, we found that the nutritional requirements across those species are different, and that a low-quality diet for one species is not necessarily low-quality for another one. While honey bees are negatively impacted by diets with a high protein content (~40%), bumblebees and mason bees develop normally on these diets but struggle on diets with a low total amino acid and sterol content, specifically with low concentrations of 24-methylenecholesterol and β-sitosterol. Overall, our study supports the need of conserving and/or introducing plant diversity into managed ecosystems to meet the natural nutritional preferences of bees at species and community level.
Encapsulated Papillary Carcinoma: A Case Report and Review of the Literature
Authors: Athanasiou Aikaterini , Khomsi Fathi , de Joliniere Bouquet , Feki Anis
Published: February 2022

Papillary neoplasms are a distinct assemblage of breast lesions whose main characteristic is the presence of fibrovascular cores which are surrounded by epithelial cells. Papillary lesions are of heterogenous nature, with similar clinical behavior and histomorphologic characteristics. Their biological patterns, however, can be quite different. According to the World Health Organization (WHO) (2019), breast tumors have been recently classified into five subdivisions of papillary neoplasms. They are namely: intraductal papilloma, papillary ductal carcinoma in situ, encapsulated papillary carcinoma (EPC), solid-papillary carcinoma and invasive papillary carcinoma. Despite the papillary architecture being easily recognized, histological variations are diagnostically challenging. The presence or absence of myoepithelial cells in the papillary cores can distinguish the malignant from the benign lesions respectively. EPC is a rare, histologically unique carcinoma type whose main characteristic is a thick fibrous capsule at the periphery and a prolific cell structure with fibrovascular stalk support. A characteristic feature is the absence of myoepithelial cells at the surrounding thick fibrous capsule. Usually, EPC maintains a slowly developing tumor despite the absence of myoepithelial cells. An EPC case presents diagnostic difficulties since it bears close resemblance to malignant and benign papillary breast lesions. Upon a clinical and radiological evaluation, EPC commonly appears as a benign lump. In mammography, the tumor is frequently found in a retroareolar position as a well-defined mass. On the other hand, in an ultrasound, the tumor will appear as a cystic lesion characterized by solid components. The clinical picture of EPC is usually an asymptomatic benign mass which at times can be felt through auto-palpation or screening mammography. A bloody nipple discharge is regarded as a common symptom. We report a case of an EPC of a 81-year-old woman who presented with a mass in the left breast.
Vestibular Aqueduct Morphology and Meniere's Disease—Development of the “Vestibular Aqueduct Score” by 3D Analysis
Authors: Noyalet Laurent , Ilgen Lukas , Bürklein Miriam , Shehata-Dieler Wafaa , Taeger Johannes , Hagen Rudolf , Neun Tilmann , Zabler Simon , Althoff Daniel , Rak Kristen
Published: February 2022

Improved radiological examinations with newly developed 3D models may increase understanding of Meniere's disease (MD). The morphology and course of the vestibular aqueduct (VA) in the temporal bone might be related to the severity of MD. The presented study explored, if the VA of MD and non-MD patients can be grouped relative to its angle to the semicircular canals (SCC) and length using a 3D model. Scans of temporal bone specimens (TBS) were performed using micro-CT and micro flat panel volume computed tomography (mfpVCT). Furthermore, scans were carried out in patients and TBS by computed tomography (CT). The angle between the VA and the three SCC, as well as the length of the VA were measured. From these data, a 3D model was constructed to develop the vestibular aqueduct score (VAS). Using different imaging modalities it was demonstrated that angle measurements of the VA are reliable and can be effectively used for detailed diagnostic investigation. To test the clinical relevance, the VAS was applied on MD and on non-MD patients. Length and angle values from MD patients differed from non-MD patients. In MD patients, significantly higher numbers of VAs could be assigned to a distinct group of the VAS. In addition, it was tested, whether the outcome of a treatment option for MD can be correlated to the VAS.