bluuebunny/crossref_metadata_2025 huggingface dataset:
Sanitation citizenship: state expectations and community practices of shared toilet use and maintenance in urban India
Authors: O’Reilly Kathleen , Budds Jessica
Published: February 2023

Although India declared itself “open defecation free” in 2019, critics charge that its national urban sanitation campaign, Swachh Bharat Mission–Urban (SBM-U), has failed. SBM-U provided community toilets in informal settlements where household latrines were unviable, delegating their upkeep to local governments and users. Initially, these community toilets were used. However, the failure to maintain and repair them resulted in a reversion to open defecation, forcing the state to reconsider its decision to withdraw after construction. We use the SBM-U to develop a framework of “sanitation citizenship”, which emerges through sanitation infrastructure’s use and disuse, and emerges over its life course. We trace how mutual expectations and everyday practices of citizenship by the state and users aligned and fractured during the construction, maintenance and repair phases of community toilets. We argue that the changing material condition of infrastructure is critical to negotiations over mutual obligations and definitions of the citizenship contract.
Tort liability for a failure to render assistance in a comparative perspective
Authors: Borysiak Witold
Published: February 2023

The article looks at the problem of tort liability for a failure to render assistance and compares the legal approaches to this issue. There are no European legal systems that regulate such a duty to render assistance directly in the provisions of private law. This is generally because most of them (with the exception of common law countries) have criminal law provisions that penalize a failure to rescue another person in need of assistance. This raises the question of the impact of criminal law on liability in private law. The paper discusses this issue in detail, accepting the opinion that, in those legal systems where a failure to render assistance is punishable as a criminal offence, the provisions of criminal law should determine the conditions and prerequisites for rendering assistance in private law and establish the boundaries of liability in tort law. In addition, the article aims to present universal guidelines that might be useful for courts in order to establish tort liability in other cases of a failure to render assistance.
Number Lines to Support Mathematical Understanding
Authors: Rojo Megan , Doabler Christian T. , Clarke Ben
Published: February 2023

The number line has been proposed as a central construct used by students to solve a range of mathematics problems. Given the capacity of number lines to represent all real numbers and to be used in a variety of contexts, there have been calls to increase the use of number lines in mathematics instruction. However, due to the recency of these recommendations coupled with the myriad ways in which number lines can be used, little hands-on guidance has been provided how best to leverage number lines in mathematics instruction. This special series details five areas in which teachers can use number lines to support acquisition of critical mathematics concepts and skills.
Evaluation of Radiographic Outcomes of Alveolar Graft Associated with Premaxillary Osteotomy Performed with rhBMP-2
Authors: Resende Leal Claudia , Rocha Leopoldo Aguiar , Carvalho Roberta Martinelli , Faco Renato André de Souza , Alonso Nivaldo , Ozawa Terumi Okada , Tonello Cristiano
Published: February 2023

Objective

To evaluate the influence of filling material and timing of surgery on radiograph outcomes of alveolar grafting with premaxillary osteotomy. The null hypothesis was that radiographic outcomes would be similar with both rhBMP-2 (rhBMP-2G) and cancellous bone from the iliac crest (IG), regardless of the timing of surgery.

Design

Cross-sectional study with consecutive sampling of 56 periapical or occlusal radiographs taken 12 months after surgery.

Setting

A single tertiary craniofacial center.

Patients/Participants

Twenty-eight patients with complete bilateral cleft lip and palate and mean age of 13 years. The individuals underwent bilateral alveolar grafting associated with premaxillary osteotomy (AG + PO) with rhBMP-2 or cancellous bone from the iliac crest.

Interventions

Experienced maxillofacial surgeons used the same surgical technique in both groups. AG + PO were assigned as success or failure by 3 blinded raters based on modified Bergland and SWAG scales.

Main Outcome Measures

The influence of filling materials and timing of surgery on radiographic outcomes was verified by Fisher's exact test and chi-square test ( P < .05).

Results

There was no significance variation between the mean age of participants in the rhBMP-2G and IG ( P = .471). Scales showed almost perfect reliability (agreement rate = 96.4%; K = 0.85). rhBMP-2G and IG had similar success rates with modified Bergland scale (85.7% and 82.1%) and SWAG scale (92.9% and 82.1%), respectively. However, only modified Bergland scale found influence of age on radiographic outcomes ( P = .025).

Conclusions

AG + PO performed with rhBMP-2 and iliac crest bone showed similar radiographic success rates, regardless of the timing of surgery.
Aberrant p53 Expression in Gastric Biopsies and Resection Specimens Following Neoadjuvant Chemoradiation: A Diagnostic Pitfall
Authors: Hutchings Danielle A. , Salimian Kevan J. , Waters Kevin M. , Birkness-Gartman Jacqueline E. , Voltaggio Lysandra , Assarzadegan Naziheh , Huang Jialing , Lin Ming-Tseh , Singhi Aatur D. , Montgomery Elizabeth A.
Published: February 2023

Gastric mucosal biopsies and resections from patients treated with neoadjuvant radiation and/or chemotherapy are frequently encountered. These samples may show histologic features related to therapy including inflammation, ulceration, and epithelial atypia. In some cases, epithelial atypia may be marked, prompting the use of adjunct p53 immunohistochemistry. We examined p53 expression by immunohistochemistry in gastric mucosa following therapy.

We evaluated the histology and p53 immunohistochemical expression in gastric mucosa from 5 7 resections and 3 mucosal biopsies, from 60 patients treated with radiation and/or chemotherapy for gastroesophageal carcinoma (n  =  33) or pancreatic carcinoma (n  =  27).

We identified histomorphologic features of therapy-related epithelial changes in 50 of 60 cases (83%). Abnormal p53 expression was present at least focally in nearly half the cases (27 of 60 cases; 45%), all of which showed morphologic evidence of therapy-related epithelial changes . Neuroendocrine cell micronests were present in 37 of 60 cases (62%). Next-generation sequencing (NGS) of foci with therapy-related epithelial changes showing abnormal p53 expression and carcinoma from the same patient was attempted and yielded results in 1 patient. Interestingly, differing TP53 alterations in the patient's adenocarcinoma and in a histologically benign esophageal submucosal gland with therapy-related epithelial changes and abnormal p53 expression were identified.

Our results demonstrate that abnormal p53 expression is relatively common in gastric mucosal samples following radiation and/or chemotherapy and suggest that p53 expression should be avoided when distinguishing therapy -related changes from dysplasia or carcinoma. Furthermore, our NGS results raise interesting biological questions, which may warrant further investigation.
Observing dominant dual-mode second-harmonic (DMSH) generation in an isotropic nonlinear elastic cylindrical waveguide
Authors: Kanakambaran Krishnadas V , Balasubramaniam Krishnan
Published: February 2023

Nonlinear ultrasonic techniques have gained much interest owing to their microstructural characterisation capabilities, which can help in early-state defect detection and provide timely maintenance activity calls. Microstructural features such as micro-cracks, precipitates or dislocations can be accessed while studying higher harmonics data via amplitude analysis. A proper understanding of second harmonic modes shall provide clarity and insights into the defect type. This paper studies and analyses the second harmonic wave modes generated while exciting fundamental torsional mode(T(0,1)) in a cylindrical wire waveguide structure. The work presents the presence of a simultaneously propagating dominant dual-mode second-harmonic (DMSH), fundamental longitudinal (l(0,1)) mode and an orthogonal-torsional (t(0,1)┴) mode generated on a cylindrical steel wire waveguide of 1 mm diameter while excited with a T(0,1) mode in a large domain. The presence of two dominant modes at second harmonic frequency is the reason for terming this phenomenon DMSH. The DMSH was observed and analysed using numerical simulations and validated experimentally. This work attempts to extend the study of DMSH generation on thin plates with SH0 mode with the analogy of cylindrical structures for rod waves with T(0,1) mode. However, in the present study of cylindrical waveguides, at primary frequency also, dual flexural modes (F(1,1)-F(1,2)) with approximately similar group velocities to DMSH were observed. These wave modes were identified with Fourier transform methods (STFT and 2D-FFT) and interpreted using dispersion curves. The dual-mode wave packets will separate in the time domain if the travel length exceeds the minimum separation distance of approximately 60 λ, depending on the variation in their respective group velocities. This approach can provide important implications for highly sensitive long-range early-state defect detection and structural health monitoring in cylindrical structures with improved insights into the generated wave modes.
Establishing the Relationship Between Attention Deficit Hyperactivity Disorder and Emotional Facial Expression Recognition Deficit: A Systematic Review
Authors: Olaya-Galindo Maria Daniela , Vargas-Cifuentes Oscar Alberto , Vélez Van-Meerbeke Alberto , Talero-Gutiérrez Claudia
Published: February 2023

Objective:

In this review, we examined if there is a deficit in facial recognition of emotion (FER) in children, adolescents, and adults with attention deficit hyperactivity disorder (ADHD).

Background:

Emotional regulation is impaired in ADHD. Although a facial emotion recognition deficit has been described in this condition, the underlying causal mechanisms remain unclear.

Methods:

The search was performed in six databases in September 2022. Studies assessing children, adolescents, or adults with isolated or comorbid ADHD that evaluated participants using a FER task were included.

Results:

Twelve studies out of 385 were selected, with participants ranging in age from 6 to 37.1 years. A deficit in FER specific to ADHD, or secondary to comorbid autism spectrum disorder, anxiety, and oppositional symptoms, was found.

Conclusions:

There is a FER deficit in patients with ADHD. Adults showed improved recognition accuracy, reflecting partial compensation. ADHD symptoms and comorbidities appear to influence FER deficits.
Biliary Atresia Remnants Revisited: Myogenesis, Hepatic Duct-Like Structures, and Fate of Peribiliary Glands
Authors: Bove Kevin E. , Finegold Milton J. , Harpavat Sanjiv
Published: February 2023

Purpose and Context:

Proximal levels of excised remnants from youngest infants may reveal early features of biliary atresia (BA).

Method:

A targeted IHC survey was applied to 34 most proximal 2 levels in 17 BA remnants excised at age 10–74 days including 7 = <30 days old and 6 control hepatic ducts (HD).

Key Results:

Severity of inflammation and extent of active fibroplasia do not distinguish proximal remnants in younger (n = 7) and older (n = 10) infants. In 27/34 levels of 14/17 remnants, reactive stroma is focally SM-MHC-2 (+), marking smooth muscle myosin, termed reactive myogenesis (RM), that is absent in controls. RM facilitates identification of 3 novel hepatic duct remnants (HDR): an HD-like collagen collar lined by degenerating cholangiocytes (n = 5); erosion defects in loose reactive stroma (n = 14); solitary foci of hyperplastic squamoid epithelium (n = 4). Peribiliary glands are either hyperplastic or atretic and typically lack RM.

Conclusion:

Minimally inflammed end-stage lesions in BA remnants occur at youngest ages favoring prenatal onset. Three novel HDR are defined. RM, a useful surrogate for HDR, is a prevalent inappropriate stromal reaction in proximal remnants of uncertain biological significance. RM is the source of mature smooth muscle in BA remnants.
Analgesic efficacy of an ultrasound-guided transversus abdominis plane block with bupivacaine in cats: a randomised, prospective, masked, placebo-controlled clinical trial
Authors: Garbin Marta , Ruel Hélène LM , Watanabe Ryota , Malo Annie , Monteiro Beatriz P , Steagall Paulo V
Published: February 2023

Objectives

This randomised, prospective, masked clinical trial evaluated the postoperative analgesic efficacy of an ultrasound-guided transversus abdominis plane block (TAPB) with bupivacaine in cats undergoing ovariohysterectomy.

Methods

Thirty-two healthy adult female cats undergoing elective ovariohysterectomy were randomised to undergo TAPB with bupivacaine (treatment group [TG], n = 16) vs placebo (control group [CG], n = 16) in addition to preoperative analgesia with buprenorphine (0.02 mg/kg IM). All patients received a general anaesthetic and, before surgical incision, a bilateral two-point (subcostal and lateral–longitudinal) TAPB was performed using 1 ml/kg bupivacaine 0.25% (0.25 ml/kg/point) or saline. Each cat was assessed by a blinded investigator before premedication (0 h) and at 1, 2, 3, 4, 8, 10 and 24 h postoperatively using the UNESP-Botucatu Feline Pain Scale – short form. Buprenorphine (0.02 mg/kg IV) and meloxicam (0.2 mg/kg SC) were administered when pain scores were ⩾4/12. Ten hours postoperatively, meloxicam was administered to cats that did not receive rescue analgesia. Statistical analysis included Student’s t-tests, Wilcoxon tests and χ2 tests, and a linear mixed model with Bonferroni corrections ( P <0.05).

Results

Of the 32 cats enrolled, three in the CG were excluded from the analysis. The prevalence of rescue analgesia was significantly higher in the CG (n = 13/13) than in the TG (n = 3/16; P <0.001). Only one cat in the CG required rescue analgesia twice. Pain scores were significantly higher in the CG compared with the TG at 2, 4 and 8 h postoperatively. Mean ± SD pain scores were significantly higher in the CG, but not in the TG, at 2 (2.1 ± 1.9), 3 (1.9 ± 1.6), 4 (3.0 ± 1.4) and 8 h postoperatively (4.7 ± 0.6) than at 0 h (0.1 ± 0.3).

Conclusions and relevance

A bilateral ultrasound-guided two-point TAPB with bupivacaine in combination with systemic buprenorphine provided superior postoperative analgesia than buprenorphine alone in cats undergoing ovariohysterectomy.
Comparing post-maturation outcomes of arteriovenous grafts and fistulae
Authors: Hafeez Muhammad Saad , Eslami Mohammad H , Chaer Rabih A , Yuo Theodore H
Published: February 2023

Background:

Though arteriovenous grafts (AVG) mature more reliably than arteriovenous fistulae (AVF) and require fewer maturation procedures (MP) to obtain functional patency, AVG are thought to have worse function after maturation. We explored differences in post-maturation outcomes between the following groups: AVF patients who did (AS-AVF) and did not (unAS-AVF) require assisted maturation and AVG patients who did (AS-AVG) and did not (unAS-AVG) require assisted maturation.

Methods:

Using the US Renal Data System (2012–2017), we retrospectively identified patients who initiated dialysis with a central venous catheter, underwent AVF or AVG placement and achieved successful two-needle cannulation. Primary patency and access abandonment after maturation were compared across groups using competing risks regression methods, generating sub-hazards ratios (sHR).

Results:

We identified 42,664 AVF and 12,335 AVG that met inclusion criteria. A larger proportion of AVFs required interventions: 18,408 AVF (43.2%) versus 2594 AVG (21.0%; p < 0.01). Both AS-AVG and AS-AVF patients experienced patency loss at 1 year more frequently compared with unAS-AVG (67.5% & 57.5% vs 55.2% respectively). Patency loss was lowest in unAS-AVF (38.9%). These trends were robust on adjusted analysis (unAS-AVG reference, AS-AVG sHR = 1.44, p < 0.01; AS-AVF sHR = 1.08, p < 0.01, unAS-AVF sHR = 0.67, p < 0.01). AS-AVGs were more likely to be abandoned than unAS-AVGs (11.7% unAS-AVG vs 17.2% AS-AVG). Fistulae, assisted or not, had lower unadjusted rates of 1-year abandonment than grafts (8.9% AS-AVF vs 7.3% unAS-AVF). On adjusted analysis, AVF usage was protective against abandonment (unAS-AVG, reference; AS-AVF sHR = 0.67, p < 0.01; unAS-AVF sHR = 0.59, p < 0.01) while AS-AVG was not (AS-AVG sHR = 1.32, p < 0.01).

Conclusions:

unAS-AVF have the best long-term outcomes. AS-AVF lose primary patency at a higher rate than unAS-AVG. AVGs may be a better choice than AVFs if veins are marginal and likely to require assisted maturation. Further research is needed to identify anatomic and physiologic factors that affect long-term performance and influence conduit choice.
Validation of the effectiveness of augmented reality-assisted vascular puncture: An experimental model
Authors: Morillas Pérez Jordi , Mechó Meca Sandra , Caballero Galindo Gerardo , Miguel Pérez-Llano Jesús
Published: February 2023

Purpose:

To demonstrate that the augmented reality-assisted puncture technique improves the efficacy of ultrasound-guided puncture to get central venous access (CVA), allows the image to be obtained without limitations, freeing the hands and keeping the gaze continuously on the working field, which contributes to improving the safety of the procedure.

Material and methods:

A gelatin mould with a latex surface and a chicken breast with silicone tubes inside were used to simulate vascular punctures. Images were obtained by an ultrasound scanner and post-processed with a specific software. A hologram was obtained and projected onto the previously delimited surface to be punctured. The variables related to image acquisition, the characteristics of the structure to be cannulated and the percentage of successes in the first attempt were analysed. Six operators were involved, using different ultrasound scanners. Efficiency was examined after the application of technical improvements in the process.

Results:

Seventy-six punctures were performed, guided by two different ultrasound scanners, divided into two groups: 37 with 33 successes (sigma = 3.52 with a process efficiency of 97.98%) and after technical improvements, 39 with 38 successes (sigma = 4.07 with a process efficiency of 99.4%). There are no significant differences among the operators (X2 p = 0.47) and between the ultrasound scanners (X2 p = 0.56).

Conclusions:

The augmented reality ultrasound-assisted CVA technique may be the next step in standardising the process of cannulation of vascular structures. This technique provides greater accuracy, greater comfort by freeing the hands and keeping the gaze on the working field, better ultrasound image quality, and eliminates variability between operators and sonographers.
Programming Plasticity as Embodied in Childhood: A Critical Genealogy of The Biology of Adversity and Resilience
Authors: Ryan Kevin
Published: February 2023

The Biology of Adversity and Resilience coheres around the claim that early childhood experiences of stress and adversity get ‘under the skin’ and become ‘biologically embedded’, increasing the risk of negative health and behavioural outcomes later in life. Taking a genealogical approach to biosocial plasticity, this article situates The Biology of Adversity and Resilience within the arc of an apparatus of power/knowledge that emerged in tandem with liberal governmentality and which assumes childhood as a means of programming the future. The argument is that The Biology of Adversity and Resilience is a normative fiction: a socially scripted story that figures the ‘resilient’ child in a way that potentially sustains extant inequalities by prefiguring a future that is in step with the neoliberal present.
The Influence of Comorbidity and Perceived Complexity on Outcomes of Referrals to Children and Young Person Mental Health Services (UK): A Mixed Methods Vignette Study
Authors: Byrne Georgia R , Shafran Roz , Whadcock Katy , Bennett Sophie D
Published: February 2023

Children and young people (CYP) with long-term physical conditions (LTCs) are four times more likely to develop mental health disorders yet many cannot access Children and Young People’s Mental Health Services (CYPMHS) or evidence-based interventions. This study aimed to understand the reasons for this; presence of an LTC neurodevelopmental disorder, or service requirements. 79 CYP mental health practitioners were randomly assigned to read vignettes depicting a hypothetical referral letter for a child with a mental health condition alone ( n = 27), mental health condition and LTC ( n = 25), or mental health condition and neurodevelopmental disorder (Autism Spectrum Disorder-ASD) ( n = 27), answering questions about their likelihood of accepting the referral and proposed treatment plan. There were no significant differences between accessing CYPMHS or being offered first line evidence-based interventions in those with a LTC or ASD compared to those without. However, additional perceived complexity was frequently provided as a reason for rejecting referrals and not offering evidence-based intervention, with clinicians’ predicted success of intervention significantly lower for these CYP. Clinicians were significantly more likely to suggest adapting the intervention in the LTC and the ASD groups to account for additional perceived complexity. The research suggests a need for additional services for CYP with LTCs and those with neurodevelopmental disorders, as well as training/awareness for clinicians.
Cross-sectional behaviour and design of normal and high strength steel welded I-sections under compression and uniaxial bending
Authors: Zhu Yufei , Yun Xiang , Gardner Leroy
Published: February 2023

A comprehensive numerical investigation into the cross-sectional behaviour and ultimate capacity of non-slender welded I-sections, made of both normal and high strength steels (NSS and HSS), under combined compression and uniaxial bending is presented. Finite element (FE) models were initially established and validated against test results collected from the literature. Subsequently, parametric studies were conducted using the validated FE models to generate extensive numerical data considering different steel grades, cross-section geometries and loading combinations. The obtained numerical data, together with the test results collected from the literature, were utilised to assess the accuracy of the traditional European (EC3) and North American (AISC) design provisions, as well as the Continuous Strength Method (CSM), for NSS and HSS welded I-sections under combined loading. The assessment indicated that the CSM was able to provide more accurate and consistent resistance predictions than the current EC3 and AISC design provisions owing to its ability to capture the spread of plasticity and strain hardening in a systematic, mechanics-based manner. Finally, the reliability levels of the different design methods were statistically evaluated in accordance with EN 1990:2002.
Sustainable heat insulation composites based on Portland cement reinforced with date palm fibers
Authors: Bellel Nadjoua , Bellel Nadir
Published: February 2023

In order to ensure thermal comfort and reduce energy consumption, a new composite based on Portland cement and date palm fiber was studied in this work. Our main objective is to study the possibility of integrating and using this new material as a thermal insulation material in the exterior coatings of buildings. Several composites were prepared for different weight concentrations (from 0% to 5%) of date palm fibers. The studied materials were analyzed by Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), thermogravimetric analysis (TGA), and scanning electron microscopy (SEM). In addition, the hot wire method was used to measure thermo-physical properties. The results show that the addition of fibers has no effect on the chemical composition of the matrix, as shown by FTIR and XRD analyzes which proves the chemical stability. The results of the TGA analysis indicate that the inclusion of date palm fibers has an effect on the thermal characteristics of the matrix. The SEM analysis shows that there is good adhesion between the Portland cement and the plant fibers used and that the date palm fibers are well incorporated into the matrix, the SEM images also showed that the inclusion of the fibers increases the porosity. In addition, the results showed that the addition of the fibers of date palm a marked decrease in thermal conductivity, which makes the material insulating. Thus, the use of fibers in cement seems to be a promising option that allows it to be applied as a thermal coating material in buildings.
Enhancement of mixed convection in a lid driven enclosure based on magnetic field presence with nanofluid
Authors: Shehata Ali I , Dawood Mohamed M Khairat , Amer Motaz , William Micheal A
Published: February 2023

Computational analysis is utilized to examine the effects of introducing nanoparticles to a square lid-driven cavity to enhance the hydro-magnet mixed convection. Constant temperatures are imposed along the square container’s vertical edges. Both the top and bottom surfaces are covered with insulation. The lid is thought to move in two ways: increasing or decreasing free convection. In addition, a horizontal magnetic field is applied uniformly. For various Hartmann numbers (Ha) (0:100), Richardson numbers (Ri) (0.001:10), and solid volume fractions (0:0.1), the results are reported. This research is based on a constant Grashof number (Gr) of 104. The effects of parameters, including the Richardson number, Hartmann number, solid volume percentage on the stream, isothermal lines, and local Nusselt numbers (Nu), were investigated numerically. In addition, given various parametric settings, the anticipated results for the average Nusselt (Nuavg) are shown and discussed. For all tested parameters, increasing the magnetic field makes the orientation of the lid more effective on heat and fluid movement. The magnetic field reduces heat and fluid flow. The heat transmission is aided by increasing the solid volume percentage. The effect of nanoparticles on flow and heat transmission is being studied. At Ri = 0.001, the effect of lid orientation is not significant. The highest reduction in heat transfer occurs when adding flow at Ri = 10,  = 0, and Ha = 100.
Are social interactions preferentially attended in real-world scenes? Evidence from change blindness
Authors: Barzy Mahsa , Morgan Rachel , Cook Richard , Gray Katie LH
Published: February 2023

In change detection paradigms, changes to social or animate aspects of a scene are detected better and faster compared with non-social or inanimate aspects. While previous studies have focused on how changes to individual faces/bodies are detected, it is possible that individuals presented within a social interaction may be further prioritised, as the accurate interpretation of social interactions may convey a competitive advantage. Over three experiments, we explored change detection to complex real-world scenes, in which changes either occurred by the removal of (a) an individual on their own, (b) an individual who was interacting with others, or (c) an object. In Experiment 1 ( N = 50), we measured change detection for non-interacting individuals versus objects. In Experiment 2 ( N = 49), we measured change detection for interacting individuals versus objects. Finally, in Experiment 3 ( N = 85), we measured change detection for non-interacting versus interacting individuals. We also ran an inverted version of each task to determine whether differences were driven by low-level visual features. In Experiments 1 and 2, we found that changes to non-interacting and interacting individuals were detected better and more quickly than changes to objects. We also found inversion effects for both non-interaction and interaction changes, whereby they were detected more quickly when upright compared with inverted. No such inversion effect was seen for objects. This suggests that the high-level, social content of the images was driving the faster change detection for social versus object targets. Finally, we found that changes to individuals in non-interactions were detected faster than those presented within an interaction. Our results replicate the social advantage often found in change detection paradigms. However, we find that changes to individuals presented within social interaction configurations do not appear to be more quickly and easily detected than those in non-interacting configurations.
Adenosine deaminase-based measurement in the differential diagnosis of pleural effusion: a multicenter retrospective study
Authors: Gao Lijuan , Wang Wujun , Zhang Ying , Hu Xueru , An Jing , Li Yang , Chen Mei , Shen Yongchun
Published: February 2023

Introduction:

The differential diagnosis of pleural effusion is difficult, and studies have reported on the potential role of adenosine deaminase (ADA) in the differential diagnosis of undiagnosed pleural effusion. This retrospective study aimed to investigate the diagnostic role of ADA in pleural effusion.

Methods:

266 patients with pleural effusion from three centers were enrolled. The concentrations of ADA and lactate dehydrogenase (LDH) were measured in pleural fluids and serum samples of the patients. The diagnostic performance of ADA-based measurement for tuberculous pleural effusion (TPE), malignant pleural effusion (MPE), and parapneumonic effusion (PPE) was examined by receiver operating characteristic (ROC) curve analysis.

Results:

An area under the ROC curve (AUC) value of 0.909 was obtained using the pleural ADA values as the indicator for TPE identification (sensitivity: 87.50%, specificity: 87.82%). The ratio of serum LDH to pleural ADA (cancer ratio) provided the predictive capacity with an AUC of 0.879 for MPE diagnosis (sensitivity: 95.04%, specificity: 67.06%). At a cut-off value of 14.29, the pleural ADA/LDH ratio showed a sensitivity and specificity of 81.13% and 83.67%, respectively, and a high AUC value of 0.888 for the differential diagnosis of PPE from TPE.

Conclusion:

ADA-based measurement is helpful for the differential diagnosis of pleural effusion. Further studies should be performed to validate these results.
Immune repertoire and responses to neoadjuvant TCHP therapy in HER2-positive breast cancer
Authors: Shin Junyoung , Ham Baknoon , Seo Jeong-Han , Lee Sae Byul , Park In Ah , Gong Gyungyub , Kim Sung-Bae , Lee Hee Jin
Published: February 2023

Background:

Despite the introduction of trastuzumab, pathologic complete response (pCR) is not attained in approximately 30–40% of Human epithelial growth factor receptor-2-positive breast cancer. Tumor-infiltrating lymphocytes (TIL) have been suggested as a predictive marker of treatment response, albeit not always effective. We investigated the relationship between trastuzumab, docetaxel, carboplatin, and pertuzumab (TCHP) treatment and immune repertoire as a treatment response predictor.

Design:

In all, 35 cases were divided into two experimental groups: 10 and 25 cases in the preliminary and main experiments, respectively. In the preliminary experiment, the biopsy tissues before TCHP treatment and the surgical tissues after TCHP treatment were compared. In the main experiment, the biopsy tissues before TCHP treatment were compared according to the TCHP treatment response.

Methods:

The T-cell repertoire for TRA, TRB, TRG, and TRD, and B-cell repertoire for immunoglobulin heavy, immunoglobulin kappa, and immunoglobulin lambda were evaluated. Whole transcriptome sequencing was also performed.

Results:

In the preliminary experiment, the density and richness of the T-cell receptor (TCR) and B-cell receptor (BCR) repertoires decreased after treatment, regardless of TCHP response. In the main experiment, the Shannon’s entropy index, density, and length of CDR3 of the TCR and BCR repertoires did not differ significantly in patients who did and did not achieve pCR. The pCR and non-pCR subgroups according to the level of TILs revealed that the non-pCR/lowTIL group had a higher proportion of low-frequency clones than the pCR/lowTIL group in TRA (non-pCR/lowTIL versus pCR/lowTIL, 0.01–0.1%, 63% versus 45.3%; <0.01%, 32.9% versus 51.8%, p < 0.001) and TRB (non-pCR/lowTIL versus pCR/lowTIL, 0.01–0.1%, 26.5% versus 14.7%; <0.01%, 72.0% versus 84.1%, p < 0.001).

Conclusions:

The role of the diversity, richness, and density of the TCR and BCR repertoires as predictive markers for TCHP response was not identified. Compositions of low-frequency clones could be candidates for predictive factors of TCHP response; however, validation studies and further research are necessary.
“I Don’t Think That’s True, Bro!” Social Corrections of Misinformation in India
Authors: Badrinathan Sumitra , Chauchard Simon
Published: February 2023

Fact-checks and corrections of falsehoods have emerged as effective ways to counter misinformation online. But in contexts with encrypted messaging applications (EMAs), corrections must necessarily emanate from peers. Are such social corrections effective? If so, how substantiated do corrective messages need to be? To answer these questions, we evaluate the effect of different types of social corrections on the persistence of misinformation in India ([Formula: see text]5,100). Using an online experiment, we show that social corrections substantially reduce beliefs in misinformation, including in beliefs deeply anchored in salient group identities. Importantly, these positive effects are not systematically attenuated by partisan motivated reasoning, highlighting a striking difference from Western contexts. We also find that the presence of a correction matters more relative to how sophisticated this correction is: substantiating a correction with a source only improves its effect in a minority of cases; besides, when social corrections are effective, citing a source does not drastically improve the size of their effect. These results have implications for both users and platforms and speak to countering misinformation in developing countries that rely on private messaging apps.
Olfaction Now and in the Future in CRSwNP
Authors: Qureshi Hannan A , Lane Andrew P
Published: February 2023

Background

Chronic rhinosinusitis (CRS) is the leading cause of olfactory dysfunction in the general population. Olfactory dysfunction is more common in patients with CRS with nasal polyposis (CRSwNP) compared to those without polyps.

Purpose

The present review aims to summarize the current literature on the mechanism behind olfactory dysfunction in CRSwNP and the impact of therapy on olfactory outcomes in this patient population.

Methods

A comprehensive review of the available literature on olfaction in CRSwNP was performed. We evaluated the most recent evidence from studies on the mechanisms behind smell loss in CRSwNP and the impact of medical and surgical therapy for CRS on olfactory outcomes.

Results

The mechanism behind olfactory dysfunction in CRSwNP is not completely understood, but evidence from clinical research and animal models suggests both an obstructive component causing conductive olfactory loss and an inflammatory response in the olfactory cleft leading to sensorineural olfactory loss. Oral steroids and endoscopic sinus surgery have both shown efficacy in improving olfactory outcomes in CRSwNP in the short term; however, the long-term response of these treatments remains uncertain. Newer targeted biologic therapies, such as dupilumab, have also shown remarkable and durable improvement in smell loss for CRSwNP patients.

Conclusion

Olfactory dysfunction is highly prevalent in the CRSwNP population. Although significant advances have been made in our understanding of olfactory dysfunction in the setting of CRS, additional studies are needed to elucidate cellular and molecular changes mediated by type 2-mediated inflammation in the olfactory epithelium with potential downstream effects on the central olfactory system. Further identification of these underlying basic mechanisms will be vital for developing future therapies targeted to improve olfactory dysfunction in patients with CRSwNP.
Core Outcome Measures in Chronic Rhinosinusitis With Nasal Polyps: In Practice and Research
Authors: Abdulghany Alaaeldein , Surda Pavol , Hopkins Claire
Published: February 2023

Heterogeneity in outcomes used in clinical trials prevents meta-analysis and contributes to research waste. Core outcome sets aim to address this by defining a small number of essential outcomes that should be measured in all effectiveness trials. Adoption in routine clinical practice can further improve outcomes for patients.

There has been a rapid growth in therapeutic options available for patients with chronic rhinosinusitis with nasal polyps, but difficulty comparing results leads to uncertainty into optimum management, and there is a need to define a core outcome set. We consider whether work already undertaken needs to be modified for patients with nasal polyps.

We recommend that a core outcome set should include assessment of disease specific quality of life, nasal polyp score, evaluation of sense of smell, alongside need for OCS and surgical treatment and complications from the disease or treatment. Further work is required to achieve international consensus regarding the choice of nasal polyp scoring system.
The Nasal Innate Immune Proteome After Saline Irrigation: A Pilot Study in Healthy Individuals
Authors: Harcourt-Smith Emily A. , Krstic Emerson T. , Soekov-Pearce Belinda J. , Colella Alex D. , Chegeni Nusha , Chataway Timothy K. , Woods Charmaine M. , Aliakbari Kamelya , Carney A. Simon
Published: February 2023

Background

Previous research has shown diminished nasal immune function following nasal saline irrigation (NSI), returning to baseline at 6 hours. The aim of this study was to examine the immune nasal proteome before and after 14 days of nasal irrigation.

Methods

Seventeen healthy volunteers received either isotonic (IsoSal) or low salt (LowNa) NSI. Nasal secretions were collected before and 30 min after NSI at baseline and again after 14 days. Specimens were analyzed using mass spectrometry to detect proteins of relevance to nasal immune function.

Results

One thousand eight hundred and sixty-five proteins were identified with significant changes in 71 proteins, of which 23 were identified as part of the innate immune system. Baseline analysis demonstrated an increase of 9 innate proteins after NSI, most after IsoSal. After 14 days, a greater increase in innate peptides was present, with most now in the LowNa group. When NSI solutions were compared, a significant increase in 4 innate proteins, including a 211% in lysozyme, was detected in the LowNa group.

Conclusion

LowNa NSI demonstrates evidence of improving the innate immune secretions, especially lysozyme, in healthy volunteers.
Is England facing an opioid epidemic?
Authors: Roberts Antonia-Olivia , Richards Georgia C
Published: February 2023

The opioid crisis in the United States (US) is one of the most high-profile public health scandals of the 21st century with millions of people unknowingly becoming dependent on opioids. The United Kingdom (UK) had the world’s highest rate of opioid consumption in 2019, and opiate-related drug poisoning deaths have increased by 388% since 1993 in England and Wales. This article explores the epidemiological definitions of public health emergencies and epidemics in the context of opioid use, misuse, and mortality in England, to establish whether England is facing an opioid crisis.
A case of atrial fibrillation complicated by complete atrioventricular block
Authors: Yanagisawa Yuuki , Ibrahim Wissam , Kumar Narendra
Published: February 2023

Atrial fibrillation and complete atrioventricular block are two well-established arrhythmias that can share common aetiologies and risk factors. Although the two arrhythmias can co-exist, only a limited number of cases of atrial fibrillation complicated by complete atrioventricular block have been reported. Correct recognition is essential due to the risk of sudden cardiac death. A 78-year-old female with known atrial fibrillation presented with a 1-week history of shortness of breath, chest tightness and dizziness. On assessment, she was bradycardic with a heart rate of 38 bpm, despite the absence of any rate-limiting medication. Electrocardiography revealed an absence of P waves with a regular ventricular rhythm, consistent with a diagnosis of atrial fibrillation complicated by complete atrioventricular block. This case highlights the diagnostic electrocardiography features of co-existing atrial fibrillation with complete atrioventricular block that are often misinterpreted, leading to a delay in correct diagnosis and initiation of definitive management. Upon diagnosis, it is essential to exclude the reversible causes of complete atrioventricular block before considering permanent pacing. In particular, this includes rate-limiting medications in patients with pre-existing arrhythmias such as atrial fibrillation and electrolyte disturbances.
Introduction to the Special Issue of “TikTok and Social Movements”
Authors: Lee Jin , Abidin Crystal
Published: February 2023

This Special Issue of “TikTok and Social Movements” emerges from an attempt to map out the landscape of social movements happening on TikTok, drawing from the online symposium “TikTok and Social Movements” hosted in September 2021 by the TikTok Cultures Research Network, a research portal for interdisciplinary scholarship on TikTok cultures. The recent growing popularity of TikTok has transformed the cultures and practices of social movements worldwide. Through the platform’s participatory affordances, many users find meaningful ways to engage with the platform and its cultures, by leading and participating in a variety of activist initiatives for global awareness, social change, and civic politics. Within this context, this introduction to the Special Issue titled “TikTok and Social Movements” begins by thinking about how social media pop cultures have served as a vehicle for mobilizing and engaging in social movements for social (in)justice and politics in the era of social media. By situating TikTok, a nascent platform and culture of short video, within the ongoing discussion of digitally mobilized movements and social justice, this introduction addresses several crucial points to consider when discussing TikTok cultures and social movements that are happening or interrupted on the platform. These points are interrogated with more details and cultural contexts in the five case studies and three expert commentaries in this Special Issue. Specifically, the collection of papers interrogate how TikTok’s interactive and creative affordances have augmented and altered our cultures, practices, politics, and power dynamics of engaging with publics for various beliefs and social agendas.
Defining Expectations for Infants With Hypoplastic Left Heart Syndrome Who Survive Initial Surgical Palliation
Authors: Greenberg Jason W. , Zafar Farhan , Winlaw David S. , Tweddell James S. , Lehenbauer David G. , Cnota James F. , Heydarian Haleh C. , Morales David L. S.
Published: February 2023

Background

Overall one-year non-mortality outcomes for surgically palliated hypoplastic left heart syndrome (HLHS) patients remain understudied. Using the metric Days Alive and Outside of Hospital (DAOH), the present study sought to characterize expectations for surgically palliated patients’ first year of life.

Methods

The Pediatric Health Information System database was used to identify by ICD-10 code all HLHS patients who underwent surgical palliation (Norwood/hybrid and/or heart transplantation [HTx]) during their index neonatal admission and were successfully discharged alive (n  =  2227) and for whom one-year DAOH could be calculated. DAOH quartiles were used to group patients for analysis.

Results

Median one-year DAOH was 304 (interquartile range [IQR] 250-327), including a median index admission length of stay of 43 days (IQR 28-77). Patients required a median 2 (IQR 1-3) readmissions, each spanning 9 days (IQR 4-20). One-year readmission mortality or hospice discharge occurred in 6% of patients. Patients with lower-quartile DAOH had a median DAOH of 187 (IQR 124-226), whereas upper-quartile DAOH patients had a median DAOH of 335 (IQR 331-340) ( P < .001). Readmission mortality/hospice-discharge rates were 14% and 1%, respectively ( P < .01). On multivariable analysis, factors independently associated with lower-quartile DAOH included interstage hospitalization (odds ratio [OR] 44.78 [95% confidence interval [CI] 25.1-80.2]), index-admission HTx (8.73 [4.66-16.3]), preterm birth (1.97 [1.34-2.90]), chromosomal abnormality (1.85 [1.26-2.73]), age >7 days at surgery (1.50 [1.14-1.99]), and non-white race/ethnicity (1.33 [1.01-1.75]).

Conclusions

In the current era, surgically palliated HLHS infants spend approximately 10 months alive and outside of the hospital, although outcomes are highly variable. Knowledge of the factors associated with lower DAOH can inform expectations and guide management decisions.
Safety and Efficacy of Right Axillary Thoracotomy for Repair of Congenital Heart Defects in Children
Authors: Said Sameh M , Greathouse Kristin C , McCarthy Christina M , Brown Nicholas , Kumar Sacha , Salem Mahmoud I , Kloesel Benjamin , Sainathan Sandeep
Published: February 2023

Background

Minimally invasive repair of congenital heart defects in children has not gained wide popularity yet compared to minimally invasive approaches in adults. We sought to review our experience with this approach in children.

Methods

This study included a total of 37 children (24 girls, 64.9%) with a mean age of 6.5 ± 5.1 years, who underwent vertical axillary right minithoracotomy for repair of a variety of congenital heart defects between May 2020 and June 2022.

Results

The mean weight of these children was 25.66 ± 18.3 kg. Trisomy 21 syndrome was present in 3 patients (8.1%). The most common congenital heart defects that were repaired via this approach were atrial septal defects (secundum in 11 patients, 29.7%; primum in 5, 13.5%; and unroofed coronary sinus in 1, 2.7%). Twelve patients (32.4%) underwent repair of partial anomalous pulmonary venous connections with or without sinus venosus defects, while 4 patients (10.8%) underwent closure of membranous ventricular septal defects. Mitral valve repair, resection of cor triatriatum dexter, epicardial pacemaker placement, and myxoma resection occurred in 1 patient (2.7%) each. No early mortality or reoperations. All patients were extubated in the operating room, and the mean length of hospital stay was 3.3 ± 2.04 days. Follow-up was complete (mean 7 ± 5 months). No late mortality or reoperations. One patient required epicardial pacemaker placement due to sinus node dysfunction 5 months after surgery.

Conclusions

Vertical axillary right thoracotomy is a cosmetically superior approach that is safe and effective for repair of a variety of congenital heart defects in children.