bluuebunny/crossref_metadata_2025 huggingface dataset:
Diagnosis and treatment of aldosterone-producing adenoma in a young patient: a clinical case
Authors: Khamnueva L. Yu. , Andreeva L. S. , Tokareva N. P. , Novozhilov A. V. , Efimov A. A. , Rozhanskaya E. V.
Published: September 2021

The prevalence of primary hyperaldosteronism (PHA) among individuals with essential arterial hypertension is about 5 to 10%. We present a clinical case of a 32 year old male patient, who despite the full clinical picture of PHA, was managed in primary care setting with the diagnosis of myalgia and treatment-resistant arterial hypertension. The article discusses clinical and laboratory parameters of the patient with the diagnosis of unilateral aldosteroma and the efficacy of its treatment. The generally accepted algorithm of PHA diagnosis with unilateral aldosterone-producing adenoma in young patients does not involve comparative selective blood sampling from adrenal veins. This accelerates the differential diagnosis and facilitates the decision to undertake surgery. This simplified diagnostic algorithm was successfully applied in the patient. Reasonable surgical intervention has led to the recovery of the patient. Awareness of various medical specialties of the up-to-date information on PHA and wide implementation of its screening into clinical practice, first of all, assessment of aldosterone-renin ratio, would allow for detection of the disease as early as possible and prevention of the development of life-threatening cardiovascular complications.
​A Study on the Housing and Feeding Management Practices Followed by Rural Milk Producers of Telangana State
Authors: Kalyani K. , Prasad R.M.V. , Rathod Suresh , Laxmi P. Jaya
Published: September 2021

An investigation was carried out to study the housing and feeding management practices followed by the dairy farmers in five districts of Telangana state. From each district one mandal and from each mandal five villages were selected. The data was collected from 150 farmers through personal interview utilizing a schedule developed for the purpose. It was observed that most of the dairy farmers (59.33%) had medium herd size and 59.33% of farmers housed their animals beside their houses while 14.67% and 26% of the farmers housed the animals in a separate shed and below the shade of tree, respectively. Most of the animal sheds (66%) in the study area had mud flooring. Majority of farmers (52%) were not taking any measures to protect animals from extreme heat in summer. Grazing and group feeding were most commonly practised except in Rangareddy district where most of farmers (56.67%) followed individual feeding. Majority of the farmers from Medak (50%) and Mahaboobnagar (60%) districts were following one time feeding of their animals, whereas, most farmers from Vikarabad (66.67%) fed two times in a day. In Rangareddy and Nalgonda, majority (66.67% and 63.33%) of the farmers were offering feed three times. Most of the farmers were producing fodder by themselves in Vikarabad, Medak, Nalgonda and Mahaboobnagar districts and their percentages were 66.67%, 63.33% 93.33% and 86.67%, respectively. Most of the farmers of Rangareddy district were procuring fodder from outside.
Behavioral Responses in Zebrafish (Danio rerio) Exposed to Heavy Metal and Insecticide Induced Stress
Authors: Huang Yi , Mi Fengjiang , Wu Junxu , Lu Yuetong , Zhang Gehong , Yu Tao
Published: September 2021

Background: Changes in fish behavior can help identify accidental chemical pollution. Heavy metals and pesticides are two of the most found pollutants to investigate the different behavioral responses of fish to these two types of pollutants exposure. Methods: Real-time computer imaging was utilized to record parameters of fish behaviors, including swimming speed, turning frequency, depth and distance between fish. Deltamethrin and cadmium were 0.015 ppm and 3.5 ppm, respectively. It was conducted for a total period of 180 min. Fish behaviors were recorded with dechlorinated water during the first 60 mins, then deltamethrin and cadmium was introduced to observe behavioral responses of zebrafish during the next 120 mins. Result: As a result of increased swimming activity, the first response of zebrafish is avoidance followed by a changed distribution in the test chamber. The duration of hyperactivity during deltamethrin exposure was lasted 35 minutes larger than Cd exposure and the average swimming depth showed totally different trends with increased from 140 mm to 226 mm during deltamethrin exposure but decreased from 161 to 84 mm during cadmium exposure. It is proved that these different responses do exist under in the two chemicals studied and this may contribute to the development of biological early warning system to separate accidental chemical pollution types.
​Boron Supplementation to Calcium Inadequate Diet Influences Mineral Content of Serum, Tissue and Antioxidant Status in White Leghorn Layers
Authors: Vijay Adarsh , Gowda N.K.S. , Pal D.T. , Dey Debpriyo Kumar , Bhat S. Karthik , Elangovan A.V.
Published: September 2021

Background: Boron (B), a novel micronutrient is known to influence utilization of macrominerals. Present study was conducted in layer birds to study the effect of B supplementation to inadequate calcium (Ca) diet on mineral content in serum, tissue and antioxidant status. Methods: A total of 80 commrcial White Leghorn layers, 25 weeks old with a uniform body weight were randomly assigned to one of the 4 groups of 20 hens in each dietary group viz., Normal calcium (NC), inadequate/low calcium (LC), Normal calcium with 40 ppm B (NCB) and inadequate/low calcium with 40 ppm B (LCB). Dietary level of calcium was maintained at 100 and 90% of the requirement and sodium borate was used as B source. At the end of feeding trial, blood and tissue samples were collected for estimating mineral and biochemical parameters. Result: Boron supplementation did not significantly alter the serum mineral content, serum alkaline phosphatase and total antioxidant activity but significantly (P less than 0.025) increased the superoxide dismutase activity in layers fed inadequate Ca diet. Boron supplementation to both diets significantly (P less than 0.03) increased phosphorus (P) content in bone and muscle, and magnesium (Mg) content in muscle (P less than 0.019). Boron supplementation to Ca inadequate diet significantly (P less than 0.006) enhanced the P and Mg content in liver. Content of B was significantly (P less than 0.01) higher in serum, bone and liver of hens supplemented 40 ppm of B. Implication of this study is amelioration of abiotic stress due to inadequate Ca intake with B supplementation. It is concluded that 40 ppm B supplementation positively influenced the Ca, P and Mg utilization and serum SOD activity.
The Importance of Multilingual Information and Plain English in Response to the COVID-19 Pandemic
Authors: Cappuzzo Barbara
Published: September 2021

Health is a common issue for all human beings. As a consequence, everyone in the world has in some way to cope with the language of medicine. This is true now more than ever due to the global health crisis caused by the current COVID-19 pandemic, which has introduced a great amount of terms, previously mostly used by epidemiologists and statisticians, but which now have entered the daily lexicon of many languages. As the medium of international scientific communication, English is the language of worldwide information about the pandemic, and the main source of terms and expressions for other languages. The impact of the COVID-19 pandemic on English lexicon has been so deep that the Oxford English Dictionary Online (OED) released special updates in 2020 to fulfil the need to document the phenomenon. However, previous studies (Khan et al. 2020; Deang and Salazar 2021) have highlighted the important question concerning the existence of several ethnic minorities who have Limited English Proficiency (LEP) and therefore do not receive sufficient and appropriate information to defend themselves adequately against SARS-CoV-2, the virus we have all been fighting for more than one year now. The aim of this study is to highlight the importance of language and translation as essential components to provide all demographic groups/communities with access to COVID-19-related information in languages other than English and enable them to follow official health key rules. The main websites of Italian governmental and nongovernmental institutions were investigated, and the analysis focused on the availability and type of content of the multilingual material, as well as on information accessibility and clarity. The results showed important differences in the number of available languages and, even more, in the level of intelligibility of COVID-19 material in the English language. In this respect, this study intends to foster the use of plain English in the dissemination material provided by the websites of the main healthcare public institutions in Italy, a country with an ever-increasing number of registered foreigners, the majority born in non-EU countries.
The Project Manager “Interfaces” in a Crisis Scenario
Authors: Di Lorenzo Daniele
Published: September 2021

A crisis induces Project Managers to use, increasingly, a specific “language” that is born from the union of two dimensions, technical-operative modalities and the mindset. The goal is to properly react to the crisis, like a pandemic scenario will. This approach directly involves the usage of “triad” (Reaction-Execution-Results) and micro-goals concepts in order to maximize the effectiveness and efficiency of the Project Manager actions within time windows. Project management is one of most important discipline in a company, especially where the project is the soul of the business and the center of the employees’ dynamic. This paper focuses on the “interfaces” between project management and other company functions. It analyzes how the “language” could induce reaction behavior based on the time-constraints and micro-goal modus operandi and how the company dynamic could change its behavioral habits towards the same common company purpose: the success of projects.
Improving the Regulation of Joint Rights in Civil Law
Authors: Nandoshvili Ekaterine
Published: September 2021

This paper focuses on analyzing the norms regulating joint rights, presents their shortcomings, and criticizes the misconceptions expressed in the legal literature about the types of common property, joint rights, and co-ownership. The paper considers the incompleteness of the provisions regulating the legal consequences of the abolition of joint rights as a serious shortcoming of the Civil Code of Georgia. A novelty is a mechanism proposed in this paper, and it is possible to assign the entire property to one of the participants in case of abolition of joint right, in exchange for compensation for the shareholder who requests the abolition of joint right and the allocation of the amount. The objective of the paper is to analyze certain aspects of the regulation of joint rights, which, together with the theoretical, have the practical importance that will contribute to a correct understanding of a number of issues and the correct qualification of the rights and obligations of participants of the legally binding relationship, rising on the basis of joint rights. To achieve this objective, logical and systematic analysis of norms as well as comparative-legal methods are used. Using these methods, it is possible to determine the strengths and weaknesses of the norms of Georgian law or to better understand their content, to identify gaps in the legislation in court practice, as well as to develop proposals and recommendations for the improvement of norms and practice. The problems are analyzed using the examples of Georgian, German, and Swiss civil law. The common features and shortcomings were identified between the Georgian and German models regarding the issue of the consequences of the abolition of joint rights. The Swiss model appears to be the most perfect and effective model among the named ones. The study found that neither in practice nor under the law is a shareholder allowed to sell the joint item in an auction by redeeming the shares of other owners. The extinction of this opportunity for the owner reduces the essence of ownership. In order to extend the guarantees for full protection of the property rights, a view is proposed on the need to develop an approach, similar to the Swiss model, and the implementation should be ensured by case law before the law is changed.
Mapping of Soil Quality Index (SQI) for Paddy Fields Using Sentinel-2 Imagery, Laboratory Analysis, and Principal Component Analysis
Authors: Sari Putri Tunjung , Indarto Indarto , Mandala Marga , Cahyono Bowo Eko
Published: September 2021

The use of intensive chemical inputs causes lower availability of nutrients, organic matter, cation exchange capacity, and soil degradation.Therefore, this study aims to assess the soil quality index (SQI) for paddy fields in Jember, East Java, Indonesia. Input data for this study consist of land cover (interpreted from the Sentinel-2 image), soil type, and slope maps. Furthermore, the procedure to calculate soil quality index (SQI) include (1) spatial analysis to create the land unit, (2) preparation of soil sampling, (3) soil chemical analysis, (4) principal component analysis (PCA), and (5) reclassifying soil quality index (SQI).  The PCA results showed that three variables i.e., % sand, total- P, and % silt were strongly correlated to SQI, while three classes namely very low, low, and medium of SQI were sufficiently used to describe the spatial variability of the paddy field. Furthermore, approximately 41.14% of the paddy field area were classed as very low while 52.23%, and 6.63% were categorized as low and medium SQI respectively. Based on the results, about 93.37% of paddy fields in Jember Regency still require improvement in soil quality via the addition of ameliorants such as organic fertilizers to increase quality and productivity. This application needs to focus on areas with very low-low quality hence, the quality increased to the medium category.

Keywords : Mapping; Soil Quality Index (SQI); PCA; Paddy field

Copyright (c) 2021 Geosfera Indonesia and Department of Geography Education, University of Jember

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Problematika Pengaturan Organisasi Sayap Partai di Indonesia
Authors: Zahri Muhammad Riyanto
Published: September 2021

AbstractEvery political party tries to maximize every component in the structure of their political party. One component that is in direct contact with the citizen is the wings of political parties, which is an important element in political parties to develop strategic political party programs that are indirectly not covered by political parties. There is an urgency to organize the wings of political parties as a form of the constitutional responsibility of the State for the right to associate and assemble of their own citizen; so that there is certainty to provide legal protection; and clarifying the socio-political status compared to other organizations. This article uses normative approach. The normative approach will be conducted by reviewing the Laws on specific issue of political party. Article show that there is an urgency to reform the model of constitutional legal regulations for WPP by making a special chapter on WPP and recommendations for the content of the ideal regulations for WPP. Keywords: Arrangement; Wings of Political Parties; Political Parties.AbstrakSetiap partai politik berusaha untuk memaksimalkan tiap-tiap komponen yang ada dalam struktur partainya. Salah satu komponen yang bersentuhan secara langsung dengan masyarakat adalah organisasi sayap partai, yang menjadi elemen penting dalam partai politik untuk mengembangkan program partai politik yang strategis yang secara tidak langsung dapat dicover oleh partai politik. Adanya urgensi untuk melakukan pengaturan organisasi sayap partai sebagai wujud tanggung jawab konstitusional Negara terhadap hak berserikat dan berkumpul warga negara; agar ada kepastian untuk memberikan perlindungan hukum; dan memperjelas status sosial-politik dibanding organisasi lainnya. Artikel ini menggunakan pendekatan normatif yaitu merujuk pada peraturan perundang-undangan yang berkaitan dengan partai politik. Artikel ini menunjukkan adanya urgensi untuk pembenahan model pengaturan hukum yang konstitusional terhadap OSP dengan membuat satu bab khusus tentang OSP dan rekomendasi muatan materi pengaturan yang ideal terhadap OSP. Kata Kunci: Pengaturan; Organisasi Sayap Partai; Partai Politik.
Keterangan Saksi dengan Gangguan Jiwa Sebagai Alat Bukti di Pengadilan
Authors: Basuki Put Fui Syafira
Published: September 2021

AbstractWitness testimony is evidence tool in the first sequence in the Criminal Procedure Code (KUHAP) so it can be said there is no criminal case which escapes from the proof of witness testimony. The legal requirement for a witness's statement is when a witness takes an oath. However, in article 171 letter b of the Criminal Procedure Code (KUHAP) states that a person may give testimony without swearing, that is, a person who has memory loss or mental illness, although sometimes his memory is back. In psychology is referred to psychopaat, but the information given cannot be justified perfectly and his information is only used as a guide or additional legal evidence tool as long as it is compatible with legal evidence tool. This study uses the typology of doctrinal research with a legislation approach, conceptual approach, and case approach. Witness testimony given without the oath is considered not a valid evidence but is used as an adjunct to perfect the strength of legal evidence tool because it can strengthen the judge's conviction.Keywords: Evidence Tool; Witnesses; Mental Disorder; Responsibility.AbstrakKeterangan saksi merupakan alat bukti pada urutan pertama dalam KUHAP sehingga dapat dikatakan bahwa tiada suatu perkara pidana yang luput dari pembuktian keterangan saksi. Syarat sah keterangan saksi adalah ketika seorang saksi mengucapkan sumpah. Namun pada pasal 171 huruf b KUHAP menyatakan bahwa seseorang boleh memberikan keterangan tanpa sumpah yaitu orang yang mengalami sakit ingatan atau sakit jiwa meskipun kadang-kadang ingatannya kembali dalam ilmu penyakit jiwa disebut dengan psychopaat, tetapi keterangan yang diberikan tidak dapat dipertanggungjawabkan secara sempurna dan keterangannya hanya dipakai sebagai petunjuk atau tambahan alat bukti sah asalkan berkesuaian dengan alat bukti sah. Penelitian ini menggunakan tipologi penelitian doktrinal dengan pendekatan perundang-undangan, pendekatan konseptual, dan pendekatan kasus. Keterangan saksi yang diberikan tanpa sumpah dinilai bukan merupakan alat bukti yang sah namun digunakan sebagai tambahan untuk menyempurnakan kekuatan pembuktian alat bukti yang sah karena dapat menguatkan keyakinan hakim.Kata Kunci: Alat Bukti; Saksi; Gangguan Jiwa; Tanggungjawab.
Female adolescents and the use of contraceptives in rural areas
Authors: Abdilla Nuzzulil Nur , Sutinah Sutinah
Published: September 2021

Contraception is an effort used to prevent pregnancy in women of childbearing age. Presently, contraception is not only used for adult women or those who have had a partner, but also for female adolescents. This study aimed to understand the practice of using contraceptives among female adolescents in rural areas. The theory used as an analytical tool was the theory of social construction by Peter L Berger and Thomas Luckmann. This study used a qualitative method. The research subjects in this study were women who used contraceptives as an adolescent. This study showed that the use of contraceptives or family planning by female adolescents in the Kabuh District is a common practice. Female adolescents interpreted family planning practices as prevention of pregnancy. The most commonly used contraceptives are the contraceptive injection and the birth control pill. Adolescents obtained preference for contraceptives from their parents and family. Meanwhile, family planning services were only provided through a midwife using the One-Stop Service method. Cultural values and customs that are deeply rooted in the Manduro community make the practice of pre-marital family planning perpetuated, even though it contradicts information in general and religion. This study concluded that the practice of pre-marital family planning is believed to be the best solution for female adolescents who are engaged but still want to seek new experiences.
Women’s resistance to domestic violence during COVID-19 pandemic: A study from Indonesia
Authors: Mas'udah Siti , Megasari Lutfi Apreliana , Saud Muhammad
Published: September 2021

COVID-19 pandemic affected the increasing frequency and intensity of a husband and wife’s interaction. The pandemic further worsened domestic violence experienced by women, and this has made them resist the violence. This study aims to unravel domestic violence and women’s resistance. The research used a qualitative method on women who experienced domestic violence amid the COVID-19 pandemic. The findings suggest that the resistance was triggered by numerous internal conflicts, such as declining income and increasingly diverse household conflicts during the pandemic. Women spontaneously resist against verbal, physical, and psychological abuse to save themselves from harm and to protect their dignity. The resistances are demonstrated in various ways, including fighting the husband back, verbal abuse, shouting, threatening to divorce, scratching, and punching the husband. Additionally, women also resorted to passive resistance by giving the silent treatment, staying away, stopping communication, not sleeping in the same bed, and refusing to serve the husband. This resistance exhibited women’s awareness to defend their rights. Women did realize that they have the right to fight back as a manner of combating gender inequality.
Clinical Symptoms of Patient with Heart Failure in Dr. Soetomo General Hospital: A Descriptive Study
Authors: Bangsa Niki Kusuma , Romdoni Rochmad , Subagyo Subagyo
Published: September 2021

Introduction: Heart failure (HF) has emerged as a cardiovascular disease with high prevalence in developing countries. The highest number was expected to increase over the next few decades. Moreover, most people with HF do not show specific symptoms earlier, thus death often occurs. This study was undertaken to give an insight into the clinical symptoms and risk factors of HF.Methods: This cross-sectional study utilized medical records from Dr. Soetomo General Hospital between 6 months (July-December 2016). Eligibility criteria included female patients diagnosed with HF at the hospital with a classification of NYHA I-IV. Risk factors data from the participants such as hypertension, diabetes mellitus, dyslipidemia, body mass index (BMI), smoking status, and history of cardiovascular disease were collected. Clinical symptoms were reported descriptively.Results: From 84 patients admitted with HF in the hospital from July until December 2016, 53 were males (63.1%). In all groups, hypertension (35.6%) was the highest prevalence risk factor, followed by diabetes mellitus (25.3%), and a history of cardiovascular disease (17.2%). In this study, the most common symptom was shortness of breathing, contributing to 72.6%, followed by chest pain (10.7%), and body weakness (6%).Conclusion: This study concluded that most of the respondents were male, aged 46-65 years old. The highest risk factor that contribute to an HF was hypertension. The most common symptom in patients with HF in the hospital was shortness of breathing. Studies further emphasize the need for primordial prevention related to symptoms and risk factors of HF.
Review of intracorporeal and extracorporeal continent urinary diversion - where do we stand in 2021?
Authors: Balzano Felicia L. , Chan Kevin G.
Published: September 2021

Robot-assisted radical cystectomy has become widely accepted as a safe and minimally invasive procedure for the treatment of bladder cancer. The urinary diversion continues to be performed completely intracorporeally or extracorporeally. Over the past decade, there has been an increasing number of continent diversions being performed intracorporeally. We evaluated the most recent literature regarding intraoperative metrics and outcomes that compare the intracorporeal and extracorporeal approaches.
Antioxidant complexes of sea buckthorn (Hippopha? rhamnoides L.) of northwest Russia
Authors: Nilova L. P. , Malyutenkova S. M.
Published: September 2021

Sea buckthorn fruits, due to the content of complexes of water- and fat-soluble antioxidants, have therapeutic and prophylactic properties. Their content depends on the species, subspecies, varieties, botanical varieties, ecological and geographical origin of sea buckthorn fruits. The paper presents the results of studies of the composition of antioxidants and antioxidant activity of three botanical varieties of sea buckthorn (Hippopha? rhamnoides L.) growing in the Leningrad region of the northwestern region of Russia. As part of the antioxidant complex, the content of phenolic antioxidants (phenolic compounds, flavonoids, phenolic acids) and vitamin C was investigated. The greatest variability of water-soluble sea buckthorn antioxidants is associated with the content of vitamin C – from 82 to 297 mg/100g, depending on the botanical variety. The content of total phenolic compounds was 600–795 mg/100g, and the content of flavonoids and phenolic acids was 265–346 and 105–170 mg/100g, respectively. In the complex of fat-soluble antioxidants of sea buckthorn fruits of different varieties, the content of vitamin E and carotenoids was investigated, which was 6.9–8.3 and 10.7–14.9 mg/100g, respectively. The content of vitamin C influences the formation of antioxidant properties determined by the DPPH method and coulometric titration of water and alcohol fractions, forming a number of botanical varieties of sea buckthorn: Orange> Vitamin> Giant. The antioxidant activity of alcoholic fractions is 1.3–1.7 times higher than that of aqueous fractions, depending on the botanical variety of sea buckthorn fruits. The content of phenolic antioxidants (total phenolic compounds, flavonoids and phenolic acids) influenced the antioxidant activity determined by the FRAP method, forming a number of sea buckthorn varieties: Vitamin> Orange> Giant
Application of the regulatory framework to minimize negative impacts the impact on the environment for the development of biotechnological approaches to its improvement
Authors: Plotnikova R. N.
Published: September 2021

The scope of application of the modern regulatory framework in the field of assessing the negative impact on the environment for food industry enterprises has been investigated. The issues of biotechnological protection of environmental objects are considered, taking into account the effective use of natural resources, production and consumption waste. An assessment of modern methods and approaches to environmental health improvement, including minimization of negative impacts, is given. An expert assessment of the environmental component of the business was carried out. It is shown that an effective environmental policy in all areas of business should be accompanied by the disclosure of environmental initiatives in information and communication networks through marketing campaigns. The main approaches to biotechnological protection of environmental objects, aimed at the efficient use of natural resources, production and consumption waste, are analyzed. Modern methods and approaches to environmental health improvement, including minimization of negative impact, are evaluated. The necessity of extraction of toxic heavy metals from waste before their disposal for storage and disposal in order to prevent damage to the environment is shown. The advantages of biochemical soil remediation for leaching metals with selection and specialized adaptation of working strains of microorganisms are noted. The need for large-scale incentives for manufacturers to introduce technological processes that minimally pollutes the environment has been established.
Development of blends of vegetable oils for a healthy diet
Authors: Kleymenova N. L.
Published: September 2021

The analysis of vegetable oils was carried out in accordance with the recommendations of physiological needs for different groups of the population and FAO / WHO to meet the need for the consumption of vegetable oils. The aim of the work is to create blends of vegetable oils with an optimized composition of polyunsaturated fatty acids ?3, ?6, ?9 for healthy human nutrition. The objects of research are vegetable oils obtained by cold pressing from milk thistle, sunflower, rapeseed and camelina. The analysis of the fatty acid composition of the oils was carried out using gas chromatography. It was found that the greatest amount of ?6 is contained in sunflower oil – 66%, in milk thistle oil – 53%, in rapeseed oil 20%, in camelina oil 17%. Camelina oil is rich in ?3 – 37%, rapeseed oil ?9 – 59%, which corresponds to the standards for these types of oils. Using the method of linear programming, the calculation of four-component blends of various types of oils, balanced by ?3, ?6, ?9, in accordance with the norms recommended for satisfying the daily nutritional needs of a person is presented. Blends of vegetable oils were designed. The ratio in fatty acid blends ?3: ?6: ?9 - 1: 1.5: 1.3 has been established. By means of modeling, 5 blends of vegetable oils with different compositions were obtained. Based on the data obtained, the partial desirability functions for each blend and the general Harrington index were calculated. The values of the desirability functions that exceed 0.9 and the generalized Harrington criterion of 0.97 were obtained, which corresponds to the standard level of the desirability scale "excellent". In this regard, it can be argued that the resulting blends have a balanced composition. It should be noted that the next step is a tasting studies in order to obtain satisfactory organoleptic characteristics.
Comparative expression of recombinant phospholipase A2 in Komagataella phaffii depending on the modification of the alpha-factor signaling peptide
Authors: Bytyak D. S. , Gladchenko Y. A. , Ryapolova A. V. , Korneeva O. S. , Motina E. A.
Published: September 2021

Currently, the Russian market of phospholipase A2 enzyme preparations is represented by commercial preparations of foreign manufacturers: Nagase (Japan) and Maxapal (the Netherlands). However, the growing demand and the need to reduce the cost of production of phospholipase A2 require the development of new super-producers of phospholipase A2. In this connection, the aim of the work is to compare the expression of recombinant phospholipase A2 in Komagataella phaffii depending on the modification of the alpha-factor signaling peptide. The object of the study is the recipient yeast strain Komagataella phaffii X-33. The studies were conducted in accordance with generally accepted norms and approaches. Phospholipase A2 genes from Streptomyces violaceoruber were used for this worK. The target sequences were synthesized in the company "Eurogen" (Russia) and cloned as part of the TE vector pUC57. In the course of the work, the genetic constructs pPICZaA-Pla2 and PPICZmf4iA-Pla2 containing the Streptomyces violaceoruber phospholipase A2 gene were assembled under the native signal a-MF and its modification mf4i. The transformation of the yeast Komagataella phaffii X-33 with the obtained genetic constructs was also carried out. As a result of the conducted studies, it was shown that on average, there were no significant differences in the level of expression and specific activity of recombinant phospholipase A2 in methylotrophic yeast K. Phaffii X-33 when using the native a-MF secretion signal and its modified version mf4i. However, the use of the secretion factor mf4i allows for higher production of phospholipase A2 in individual clones. The obtained data indicate the prospects of using the secretion factor mf4i to create super-producers of enzymes based on yeast K. Phaffii X-33.
Dispersed filler based on synthetic calcium carbonate – requirements for applications quality
Authors: Natarova E. S. , Nehcesova Y. M.
Published: September 2021

The introduction of fillers into various materials improves its technological, physical and mechanical properties, and leads to a decrease in cost. The main areas of application of natural and synthetic calcium carbonate as highly dispersed fillers are: the construction industry, the production of Portland cement, mineral fertilizers, glass, paper, polymer composite materials, paints and varnishes, and rubbers. A promising direction at present is the use of production by-products as fillers, for example, conversion calcium carbonate - a waste product from the production of a complex mineral fertilizer - nitroammophoska. However, its use in the above areas is limited by the content of water-soluble nitrogen-containing impurities, impurities of heavy metals, strontium carbonate, phosphates, etc. The analysis of scientific, technical and patent literature on methods of purification of conversion calcium carbonate has been carried out. These methods are based on the extraction of impurities from the initial product of calcium carbonate production - a melt of calcium nitrate tetrahydrate by precipitation with various reagents, followed by the isolation of an insoluble precipitate (impurities) and processing of the purified melt into calcium carbonate and nitroammofoska. A method is proposed for the extraction of acid-tonic-soluble iron-containing impurities from the initial calcium nitrate melt in order to obtain a cleaner by-product - conversion calcium carbonate, which will expand the scope of its application. An effective method is to dilute the initial calcium nitrate melt with a 60% solution of ammonium nitrate to a calcium content of 12-13%, followed by the isolation of an acid-insoluble precipitate in a vacuum filter, conversion of the purified calcium nitrate solution with ammonium carbonate and separation of the resulting suspension in a drum filter. The described method can reduce the amount of iron-containing impurities by more than 50%.
Investigation of the quality of water in the process of its purification using ultrafiltration by the method of differential scanning calorimetry
Authors: Saranov I. A. , Niftaliev S. I. , Toroptsev V. V. , Kuznetsov I. A.
Published: September 2021

The increased interest in ultrafiltration technology in the last decade is caused by the search for new purification methods that allow obtaining high-quality drinking water that meets modern regulatory requirements. Modern water purification schemes use an ultrafiltration unit before reverse osmosis in softening, desalination and demineralization of water for food production. The pore size of ultrafiltration membranes ranges from 5 nm to 0.05-0.1 microns. Using ultrafiltration instead of the traditional water treatment scheme, makes it possible to obtain water with a low content of suspended and colloidal substances, increase the productivity and serviceability of reverse osmosis membranes. The water treatment scheme may contain the following modules: coarse filter; ultrafiltration unit, buffer tank; mixer; water container; reverse osmosis installation; pumps. The method of differential scanning microscopy is used to assess the quality of water during its purification. Water samples were cooled with liquid nitrogen to -30 ? and then heated to 30 ?. Crystals melting peaks were recorded on the DSC curves, and the thermal effect was calculated. During the water purification process, the value of the thermal effect of frozen water samples melting declines (from 515.1 to 261.2 J / g), the value of the temperatures at the onset (from 0.7 to -0.13 ?) and at the peak of crystal melting (from 7.45 up to 4.27 ?). The difference between the heat effect data for water samples after coarse filtration and ultrafiltration is small, which indicates that the ultrafiltration unit allows cations and anions to pass through, which preserves the salt balance of water.
Analysis of the efficiency of agricultural production
Authors: Akbasheva A. A. , Dzakhmisheva I. S. , Masalova Y. V.
Published: September 2021

The scientific article presents the results of the analysis of the state of functioning of agricultural enterprises. The natural and economic situation in the region makes it possible to intensively develop the production of marketable products in all sectors of the agro-industrial complex, including fruit and vegetable growing in terms of profitability. Fruit and vegetable products are one of the most important types that are in high demand among the population and consumers outside the region. The Kabardino-Balkarian Republic is the largest producer of fruits and vegetables in the North Caucasus Federal District. Studies have shown that the main factors determining the growth of the gross production of vegetables and berries is the expansion of areas for fruit and berry crops by half by 2010. Based on the research carried out, it is confirmed that the use of intensive technologies in the production of fruits and berries provides a fairly high increase in yield. Due to the fact that fruit and berry crops are perishable food products, it is necessary to bring them to the end consumer in a presentable form as soon as possible. One of the problems often encountered for the further development of fruit and berry production is the incompletely established links between producers and various services that perform the functions of storage, transportation, processing and delivery of products to end consumers. Therefore, farms of all categories should take into account first and foremost when developing policies for managing production activities and forecasting. Increasing the efficiency of production of fruit and berry products and continuous saturation of the consumer market with high-quality fruit and berry products is possible in the context of the introduction of the introduction of intensive methods of agricultural technology, strengthening of state support measures in the context of the application of the results of analysis of the effectiveness of the activities of farms of all categories. An increase in the gross yield of fruits and berries can be achieved as a result of planting orchards using adapted varieties that are resistant to current climatic conditions.
Comparative analysis of brand management strategies
Authors: Kostrova Y. B. , Lyashchuk Y. O. , Cherkashina L. V. , Shibarshina O. Y.
Published: September 2021

The article considers the process of branding as a means of self-promotion and personal expression. When conducting the study, the authors used the theory of consumer behavior of A. Maslow as a methodological basis, as well as the visual structures of the personality of Z. Freud, K. Jung. The aim of the study is to analyze the process of branding as a psycho-logical means of self-promotion and personality expression. During the study, general scientific methods of cognition were used within the framework of dialectical and systemic approaches, methods of logical and situational analysis. The main tasks of personal expression, solved with the help of brand products, have been identified. At the same time, the authors argue that the choice of brand products for self-promotion in all three cases is based on one psychological motive - self-realization and self-expression. It is shown that the brand brings additional income, since many consumers are ready to overpay, giving an additional amount of money for the opportunity to have a prestigious product even for a premium price. Brands have an emotional connection with consumers. Leading companies with famous brands have long noted for themselves that the connection of their goods with consumers lies through emotions. Brands help people fulfill their dreams, desires, open up more opportunities in life. The stronger and more significant the unique, rational and emotional characteristics of the brand for the consumer, the higher the price he is willing to pay for the product, the greater the opportunity for the company to profit. The increase in profits in turn leads to an increase in the value of shares and to an increase in the value of the company itself, since the brand is a kind of intangible asset. Brand ownership is a winning result of the history of the company, the fate of its founders and executives, skillful talented brand makers. Not every name of the company can be called a brand, not everyone is destined to become one, not everyone is given to maintain the level of the brand. Having a brand means that even with approximately equal consumer and other properties, the product will buy more, the idea will have more adherents.
Cell Fusion as a Link between the SARS-CoV-2 Spike Protein, COVID-19 Complications, and Vaccine Side Effects
Authors: Lazebnik Yuri
Published: September 2021

A distinctive feature of the SARS-CoV-2 spike protein is its ability to efficiently fuse cells, thus producing syncytia found in COVID-19 patients. This commentary proposes how this ability enables spike to cause COVID-19 complications as well as side effects of COVID-19 vaccines, and suggests how these effects can be prevented..
Multi-objective UAV Positioning Mechanism for Sustainable Wireless Connectivity in Environments with Forbidden Flying Zones
Authors: Atlı İbrahim , Ozturk Metin , Valastro Gianluca Camillo , Asghar Muhammad Zeeshan
Published: September 2021

Unmanned aerial vehicles (UAVs)-based communication system is a promising solution to meet coverage and capacity requirements of future wireless networks. However, UAV-enabled communications is constrained with its coverage, energy consumption, and flying regulations, and the number of works focusing on the sustainability aspect of UAV-assisted networking has been limited in the literature so far. In this paper, we propose a solution to this limitation; particularly, we design a $Q$-learning-based UAV positioning scheme for sustainable wireless connectivity considering key constraints, that are, altitude regulations, non-flight zones, and transmit power. The objective is to find the optimal position of the UAV base station (BS) and minimize the energy consumption while maximizing the number of users covered. Moreover, a weighting mechanism is developed, where the energy consumption and number of users covered can be prioritized according to network/battery conditions. The proposed Q-learning-based solution is compared to the baseline k-means clustering method, where the UAV BS is positioned at the centroid location that minimizes the cumulative distance between the UAV BS and the users. The results demonstrate that the proposed solution outperforms the baseline k-means clustering-based method in terms of the number of users covered while achieving the desired minimization of the energy consumption.
Colloidal Shear Thickening Fluids Using Variable Shaped Functional Star Particles: A Molecular Dynamics Study
Authors: Salehin Rofiques , Xu Rongguang , Papanikolaou Stefanos
Published: September 2021

Complex colloidal fluids, depending on particulates’ shapes and packing fractions, may have a wide range of shear thinning and thickening behaviors. A particular interesting way to transition between different types of such behavior is by infusing functional complex particles that can be manufactured using modern techicques such as 3D printing. In this paper, we display 2D molecular dynamics simulations of such fluids with infused star-shaped functional particles, with variable leg length and number of legs, as they are infused in a non-interacting, coarse-grained fluid. We vary the packing fraction (ϕ) of the system, and for each different system we apply shear with various strain rate that turns the fluid into a jammed state and rise the apparent viscosity of fluid. We demonstrate the dependence of viscosity with the particles’ packing fraction. We show the role of shape and design dependence of the functional particles towards the transition to a shear thickening fluid .
Δ9–Tetrahydrocannabinol (THC)-Rich Compositions from Cannabis Have Cytotoxic Activity Against Ovarian Cancer Cells and Act Synergistically With Niraparib in vitro
Authors: Shalev Nurit , Kendall Michelle , Anil Seegehalli M , Vinayaka Ajjampura C , Koltai Hinanit
Published: September 2021

Ovarian cancer (OC) is the most lethal gynecologic malignancy. Cannabis sativa is being used to treat different medical conditions. We sought to examine the effectiveness of combinations of cannabis compounds against OC. Cytotoxic activity was determined by XTT assay on HTB75 and HTB161 cell lines. Apoptosis and cell cycle were determined by fluorescence-activated cell sorting (FACS). Gene expression was determined by quantitative PCR. The two most active fractions, F5 and F7, from a high Δ9–tetrahydrocannabinol (THC) cannabis strain extract and their standard mix (SM) showed cytotoxic activity against OC cells. The most effective phytocannabinoid combination was THC+cannabichromene (CBC)+cannabigerol (CBG). F5, F7 and SM affected cell cycle, led to cell apoptosis and to a marked reduction in cell migration. Moreover, these fractions act in synergy with niraparib, and were ~50 fold more cytotoxic to OC cells than to normal keratenocytes. Niraparib+F7 treatment was effective on OC patient's cells. F7 and the niraparin+fraction (F5 and F7) treatments reduced Mitogen-Activated Protein Kinase 4 (MAPK4) gene expression; this reduction may act in synergy with the niraparib inhibition of Poly (ADP-ribose) polymerase 1 (PARP1) activity. Combinations of cannabis compounds and niraparib should be examined for efficacy in pre-clinical studies and clinical trials.
Inflation Forecasting for East Kalimantan Province Using Hybrid Singular Spectrum Analysis- Autoregressive Integrated Moving Average Model
Authors: Arumsari Melisa , Wahyuningsih Sri , Siringoringo Meiliyani
Published: September 2021

The Singular Spectrum Analysis (SSA)-Autoregressive Integrated Moving Average (ARIMA) hybrid method is a good combination of forecasting methods to improve forecasting accuracy and is suitable for economic data that tends to have trend and seasonal patterns, one of which is inflation data. The purpose of this study is to obtain the results of inflation forecasting for East Kalimantan Province in 2021 using the SSA-ARIMA hybrid model. The results of the inflation forecasting for East Kalimantan Province in 2021 using the SSA-ARIMA(1,1,1) hybrid model overall experienced an increase and the highest inflation in 2021 occurred in December of 0.92% with a forecasting accuracy level based on the Root Mean Square Error (RMSE) was 0.069399 and Mean Absolute Percentage Error (MAPE) was 32.61084%