bluuebunny/crossref_metadata_2025 huggingface dataset:
Opioid-Prescribing Trends in San Diego County, 2008-2019
Authors: Smith Joshua R. , Salven Sarah , Beÿ Christian K. , Thihalolipavan Sayone , Lev Roneet , Koenig Kristi L.
Published: December 2021

Context:

In 2019, drug overdoses accounted for 70 630 deaths in the United States, 70.6% of which involved an opioid. Approximately 28% of these deaths involved prescription medications, representing a significant number nationally. Local, state, and national efforts continue to address the impact of prescription medications within the ongoing opioid epidemic.

Objective:

This study examines trends in opioid prescription patterns from 2008 to 2019 in San Diego County, California, a major metropolitan area and the fifth most populous county in the United States. A timeline of events highlighting local, state, and national milestones is included to better contextualize distinct trends.

Design:

Collection and analysis of annual Prescription Drug Monitoring Program (PDMP) data for San Diego County.

Setting:

San Diego County, California.

Participants:

Prescribing physicians using the Controlled Substance Utilization Review and Evaluation System (CURES 2.0), California's PDMP.

Main Outcome Measures:

Prescribing data for all opioids were aggregated by formulation and strength and then converted into morphine milligram equivalents (MME) per person using CDC (Centers for Disease Control and Prevention) conversion guidelines and local population estimates. Additional outcomes analyzed include the number of prescriptions dispensed, number of pills per prescription, pill strength, and specific drug.

Results:

Total opioids prescribed increased by 29.7% from 2008 (399 MME per person) to 2012 (517 MME per person) and subsequently decreased by 54.4% from 2012 to 2019 (235 MME per person). The annual decrease in total MME from 2012 to 2019 averaged 5.9%. However, the 2-year decrease in MME from 2017 to 2019 was 35.1%, indicating an accelerated reduction in recent years.

Conclusions:

Opioid-prescribing trends in San Diego County from 2008 to 2019 are defined by 2 distinct periods. These trends may serve as an example of how local, state, and national efforts focusing on prescriber outreach, patient education, and regulatory oversight can address the impact of prescription opioids on the ongoing opioid epidemic.
Enhancing Response to Foodborne Disease Outbreaks: Findings of the Foodborne Diseases Centers for Outbreak Response Enhancement (FoodCORE), 2010-2019
Authors: Tilashalski Frances P. , Sillence Elizabeth M. , Newton Anna E. , Biggerstaff Gwen K.
Published: December 2021

Context:

Each year, foodborne diseases cause an estimated 48 million illnesses resulting in 128000 hospitalizations and 3000 deaths in the United States. Fast and effective outbreak investigations are needed to identify and remove contaminated food from the market to reduce the number of additional illnesses that occur. Many state and local health departments have insufficient resources to identify, respond to, and control the increasing burden of foodborne illnesses.

Program:

The Centers for Disease Control and Prevention (CDC) Foodborne Diseases Centers for Outbreak Response Enhancement (FoodCORE) program provides targeted resources to state and local health departments to improve completeness and timeliness of laboratory, epidemiology, and environmental health activities for foodborne disease surveillance and outbreak response.

Implementation:

In 2009, pilot FoodCORE centers were selected through a competitive application process and then implemented work plans to achieve faster and more complete surveillance and outbreak response activities in their jurisdiction. By 2019, 10 centers participated in FoodCORE: Colorado, Connecticut, Minnesota, New York City, Ohio, Oregon, South Carolina, Tennessee, Utah, and Wisconsin.

Evaluation:

CDC and FoodCORE centers collaboratively developed performance metrics to evaluate the impact and effectiveness of FoodCORE activities. Centers used performance metrics to document successes, identify gaps, and set goals for their jurisdiction. CDC used performance metrics to evaluate the implementation of FoodCORE priorities and identify successful strategies to develop replicable model practices. This report provides a description of implementing the FoodCORE program during year 1 (October 2010 to September 2011) through year 9 (January 2019 to December 2019).

Discussion:

FoodCORE centers address gaps in foodborne disease response through enhanced capacity to improve timeliness and completeness of surveillance and outbreak response activities. Strategies resulting in faster, more complete surveillance and response are documented as model practices and are shared with state and local foodborne disease programs across the country.
Postoperative delirium in older patients with cancer: the role of psychological distress and social support
Authors: O’Hanlon Shane , Baxter Mark , Hosie Annmarie
Published: December 2021

Purpose of review

Delirium is a common and important adverse event in the perioperative period. Older people with cancer are at significant risk, and outcomes are poor. There is increasing awareness of the effect of psychological distress and social support on pathogenesis and outcomes of delirium in this setting. This review aimed to describe recent research in this evolving area.

Recent findings

Across six recent studies of postoperative delirium in older people with cancer, delirium incidence ranged from 8 to 19.8%. Poor social support and high levels of distress are implicated in the development of postoperative delirium. Distress can be related to negative emotional reaction to diagnosis, preconception of cancer diagnosis and interactions with the healthcare system. Prevention of delirium is key, and multicomponent interventions show evidence of effectiveness. ‘Emotional distress’ has been included in a new core outcome set for studies of interventions to prevent and/or treat delirium.

Postoperative delirium in older adults with cancer is common and is associated with increased morbidity and mortality. Psychological distress and social support play an important role, but there are many unmet research needs in this area.
Microbe Profile: Buchnera aphidicola: ancient aphid accomplice and endosymbiont exemplar
Authors: Moran Nancy A.
Published: December 2021

Buchnera aphidicola

is an obligate endosymbiont of aphids that cannot be cultured outside of hosts. It exists as diverse strains in different aphid species, and phylogenetic reconstructions show that it has been maternally transmitted in aphids for >100 million years.

B. aphidicola

genomes are highly reduced and show conserved gene order and no gene acquisition, but encoded proteins undergo rapid evolution. Aphids depend on

B. aphidicola

for biosynthesis of essential amino acids and as an integral part of embryonic development. How

B. aphidicola

populations are regulated within hosts remains little known.
Myofibroblast Senescence Promotes Arrhythmogenic Remodeling in the Aged Infarcted Rabbit Heart
Authors: Baggett Brett C. , Murphy Kevin R. , Sengun Elif , Mi Eric , Cao Yueming , Turan Nilufer , Lu Yichun , Scofield Lorraine , Kim Tae Yun , Kabakov Anatoli Y. , Bronk Peter , Qu Zhilin , Camelliti Patrizia , Dubielecka Patrycja , Terentyev Dmitry , Monte Federica Del , Choi Bum-Rak , Sedivy John , Koren Gideon
Published: December 2021

Progressive tissue remodeling after myocardial infarction (MI) promotes cardiac arrhythmias. This process is well studied in young animals, but little is known about pro-arrhythmic changes in aged animals. Senescent cells accumulate with age and accelerate age-associated diseases. Senescent cells interfere with cardiac function and outcome post-MI with age, but studies have not been performed in large animals, and the mechanisms are unknown. Here, we investigated the role of senescence in regulating inflammation, fibrosis, and arrhythmogenesis in young and aged infarcted rabbits. Aged rabbits exhibited increased peri-procedural mortality and arrhythmogenic electrophysiological remodeling at the infarct border zone (IBZ) compared to young rabbits. Studies of the aged infarct zone revealed persistent myofibroblast senescence and increased inflammatory signaling over a twelve-week timecourse. Senescent IBZ myofibroblasts in aged rabbits appear to be coupled to myocytes, and our computational modeling showed that senescent myofibroblast- cardiomyocyte coupling prolongs action potential duration (APD) and facilitates conduction block permissive of arrhythmias. Aged infarcted human ventricles show levels of senescence consistent with aged rabbits, and senescent myofibroblasts also couple to IBZ myocytes. Our findings suggest that senolytic drugs may mitigate arrhythmias post-MI.
A phase-shifting anterior-posterior network organizes global phase relations
Authors: Menceloglu Melisa , Grabowecky Marcia , Suzuki Satoru
Published: December 2021

Prior research has identified a variety of task-dependent networks that form through inter-regional phase-locking of oscillatory activity that are neural correlates of specific behaviors. Despite ample knowledge of task-specific functional networks, general rules governing global phase relations have not been investigated. To discover such general rules, we focused on phase modularity, measured as the degree to which global phase relations in EEG comprised distinct synchronized clusters interacting with one another at large phase lags. Synchronized clusters were detected with a standard community-detection algorithm, and the degree of phase modularity was quantified by the indexq. Notably, we found that the mechanism controlling phase modularity is remarkably simple. A network comprising anterior-posterior long-distance connectivity coherently shifted phase relations from low-angles (|Δθ| < π/4) in low-modularity states (bottom 5% inq) to high-angles (|Δθ| > 3π/4) in high-modularity states (top 5% inq), accounting for fluctuations in phase modularity. This anterior-posterior network may play a fundamental functional role as (1) it controls phase modularity across a broad range of frequencies (3-50 Hz examined) in different behavioral conditions (resting with the eyes closed or watching a silent nature video) and (2) neural interactions (measured as power correlations) in beta-to-gamma bands were consistently elevated in high-modularity states. These results may motivate future investigations into the functional roles of phase modularity as well as the anterior-posterior network that controls it.
Minimal observed impact of HLA genotype on hospitalization and severity of SARS-CoV-2 infection
Authors: Nguyen Austin , Yusufali Tasneem , Hollenbach Jill A. , Nellore Abhinav , Thompson Reid F.
Published: December 2021

HLA is a critical component of the viral antigen presentation pathway. We investigated the relationship between severity of SARS-CoV-2 disease and HLA type in 3,235 individuals with confirmed SARS-CoV-2 infection. We found only the DPB1 locus to be associated with the binary outcome of whether an individual developed any COVID-19 symptoms. The number of peptides predicted to bind to an HLA allele had no significant relationship with disease severity both when stratifying individuals by ancestry or age and in a pooled analysis. Age, BMI, asthma status, and autoimmune disorder status were predictive of severity across multiple age and individual ancestry stratificiations. Overall, at the population level, we found HLA type is significantly less predictive of COVID-19 disease severity than certain demographic factors and clinical comorbidities.
An enzyme-based system for the extraction of small extracellular vesicles from plants
Authors: Zhao Qing , Liu Guilong , Xie Manlin , Zou Yanfang , Guo Zhaodi , Liu Fubin , Dong Jiaming , Ye Jiali , Cao Yue , Sun Ge , Zheng Lei , Zhao Kewei
Published: December 2021

Plant-derived nanovesicles (NVs) and extracellular vesicles (EVs) are considered to be the next generation of nanocarrier platforms for biotherapeutics and drug delivery. However, EVs exist not only in the extracellular space, but also within the cell wall. Due to the limitation of isolation methods, the extraction efficiency is low, resulting in the waste of a large number of plants, especially rare and expensive medicinal plants.There are few studies comparing EVs and NVs. To overcome these challenges, we proposed and validated a novel method for the isolation of plant EVs by degrading the plant cell wall with enzymes to release the EVs in the cell wall, making it easier for EVs to break the cell wall barrier and be collected. We extracted EVs from the roots of Morinda officinalis by enzymatic degradation(MOEVs) and nanoparticles by grinding method (MONVs) as a comparison group. The results showed smaller diameter and higher yield of MOEVs.Both MOEVs and MONVs were readily absorbed by endothelial cells without cytotoxicity and promoted the expression of miR-155. The difference is that the promotion of miR-155 by MOEVs is dose-effective. More importantly, MOEVs and MONVs are naturally characterized by bone enrichment. These results support that EVs in plants can be efficiently extracted by enzymatic cell wall digestion and also confirm the potential of MOEVs as therapeutic agents and drug carriers.
Spherical harmonic based noise rejection and neuronal sampling with multi-axis OPMs
Authors: Tierney Tim M , Mellor Stephanie , O’Neill George C , Timms Ryan C , Barnes Gareth R
Published: December 2021

In this study we explore the interference rejection and spatial sampling properties of multi-axis Optically Pumped Magnetometer (OPM) data. We use both vector spherical harmonics and eigenspectra to quantify how well an array can separate neuronal signal from environmental interference while adequately sampling the entire cortex. We found that triaxial OPMs have superb noise rejection properties allowing for very high orders of interference (L=6) to be accounted for while minimally affecting the neural space (2dB attenuation for a 60-sensor triaxial system). To adequately model the signals arising from the cortex, we show that at least 11th order (143 spatial degrees of freedom) irregular solid harmonics or 95 eigenvectors of the lead field are needed to model the neural space for OPM data (regardless of number of axes measured). This can be adequately sampled with 75-100 equidistant triaxial sensors (225-300 channels) or 200 equidistant radial channels. In other words, ordering the same number of channels in triaxial (rather than purely radial) configuration gives significant advantages not only in terms of external noise rejection but also minimizes cost, weight and cross-talk.
Copper Acts Synergistically with Fluconazole in Candida glabrata by Compromising Drug Efflux, Sterol Metabolism, and Zinc Homeostasis
Authors: Gaspar-Cordeiro Ana , Amaral Catarina , Pobre Vânia , Antunes Wilson , Petronilho Ana , Paixão Paulo , P. Matos António , Pimentel Catarina
Published: December 2021

The synergistic combinations of drugs are promising strategies to boost the effectiveness of current antifungals and thus prevent the emergence of resistance.

In this work, we show that copper and the antifungal fluconazole act synergistically against Candida glabrata, an opportunistic pathogenic yeast intrinsically tolerant to fluconazole.

Analyses of the transcriptomic profile of C. glabrata after the combination of copper and fluconazole showed that the expression of the multidrug transporter gene CDR1 was decreased, suggesting that fluconazole efflux could be affected. In agreement, we observed that copper inhibits the transactivation of Pdr1, the transcription regulator of multidrug transporters and leads to the intracellular accumulation of fluconazole. Copper also decreases the transcriptional induction of ergosterol biosynthesis (ERG) genes by fluconazole, which culminates in the accumulation of toxic sterols. Co-treatment of cells with copper and fluconazole should affect the function of proteins located in the plasma membrane, as several ultrastructural alterations, including irregular cell wall and plasma membrane and loss of cell wall integrity, were observed. Finally, we show that the combination of copper and fluconazole downregulates the expression of the gene encoding the zinc-responsive transcription regulator Zap1, which possibly, together with the membrane transporters malfunction, generates zinc depletion. Supplementation with zinc reverts the toxic effect of combining copper with fluconazole, underscoring the importance of this metal in the observed synergistic effect.

Overall, this work, while unveiling the molecular basis that supports the use of copper to enhance the effectiveness of fluconazole, paves the way for the development of new metal-based antifungal strategies.
Identifying control ensembles for information processing within the cortico-basal ganglia-thalamic circuit
Authors: Vich Catalina , Clapp Matthew , Verstynen Timothy , Rubin Jonathan E.
Published: December 2021

In situations featuring uncertainty about action-reward contingencies, mammals exhibit a high degree of flexibility in adopting strategies for decision-making that are tuned in response to the conditions that they encounter. Although the cortico-basal ganglia thalamic (CBGT) network is implicated in information processing during decisions, it features a complex synaptic architecture, comprised of multiple feed-forward, reciprocal, and feedback pathways, that complicate efforts to elucidate the roles of specific CBGT populations in the process of evidence accumulation. In this paper we apply a strategic sampling approach, based on Latin hypercube sampling, to explore how variations in CBGT network properties, including subpopulation firing rates and synaptic weights, map to variability of parameters in a normative drift diffusion model (DDM), representing algorithmic aspects of information processing during decision-making. Through the application of canonical correlation analysis, we find that this relationship can be characterized in terms of three low-dimensional control ensembles within the CBGT network that impact specific qualities of the emergent decision policy: responsiveness (associated with overall activity in corticothalamic and direct pathways), pliancy (associated largely with overall activity in components of the indirect pathway of the basal ganglia), and choice (associated with differences in direct and indirect pathways across action channels). These analyses provide key mechanistic predictions about the roles of specific CBGT network elements in tuning information processing dynamics during decisions.

Author summary

Mammals are continuously subjected to uncertain situations in which they have to choose among behavioral options. The cortico-basal ganglia-thalamic (CBGT) circuit is a complicated collection of interconnected nuclei believed to strongly influence the ability to adapt to environmental changes. The roles of specific CBGT components in controlling information during decisions remains unclear. At a more phenomenological, algorithmic level, drift-diffusion models have been shown to be able to reproduce behavioral data (action selection probabilities and the time needed to make a decision) obtained experimentally from mammals and to provide an abstract representation of a decision policy. In this work, we use simulated decision-making to establish a mapping from neural activity in the CBGT circuit to behavioral outcomes. This mapping illuminates the importance of three core sets of CBGT subnetworks in the action selection process and how they are involved in adapting decision policies across exploitative and exploratory situations.
Molecular insights into antibody-mediated protection against the prototypic simian immunodeficiency virus
Authors: Zhao Fangzhu , Berndsen Zachary T. , Pedreño-Lopez Nuria , Burns Alison , Allen Joel D. , Barman Shawn , Lee Wen-Hsin , Chakraborty Srirupa , Gnanakaran Sandrasegaram , Sewall Leigh M. , Ozorowski Gabriel , Limbo Oliver , Song Ge , Yong Peter , Callaghan Sean , Weisgrau Kim L. , Lifson Jeffrey D. , Nedellec Rebecca , Voigt Thomas B , Laurino Fernanda , Louw Johan , Rosen Brandon C. , Ricciardi Michael , Crispin Max , Desrosiers Ronald C. , Rakasz Eva G. , Watkins David I. , Andrabi Raiees , Ward Andrew B. , Burton Dennis R. , Sok Devin
Published: December 2021

SIVmac239 infection of macaques is a favored model of human HIV infection. However, the SIVmac239 envelope (Env) trimer structure, glycan occupancy, and the targets and ability of neutralizing antibodies (nAbs) to protect against SIVmac239 remain unknown. Here, we report the isolation of SIVmac239 nAbs that recognize a glycan hole and the V1/V4 loop. A high-resolution structure of a SIVmac239 Env trimer-nAb complex shows many similarities to HIV and SIVcpz Envs, but with distinct V4 features and an extended V1 loop. Moreover, SIVmac239 Env has a higher glycan shield density than HIV Env that may contribute to poor or delayed nAb responses in SIVmac239-infected macaques. Passive transfer of a nAb protects macaques from repeated low dose intraveneous SIVmac239 challenge at serum titers comparable to those described for protection of humans against HIV infection. Our results provide structural insights for vaccine design and shed light on antibody-mediated protection in the SIV model.
Circulating neurofilament light chain as a promising biomarker of AAV-induced dorsal root ganglia toxicity in nonclinical toxicology species
Authors: Fader Kelly A. , Pardo Ingrid D. , Kovi Ramesh C. , Somps Christopher J. , Wang Helen Hong , Vaidya Vishal S. , Ramaiah Shashi K. , Sirivelu Madhu P.
Published: December 2021

Adeno-associated virus (AAV)-induced dorsal root ganglia (DRG) toxicity has been observed in several nonclinical species, where lesions are characterized by neuronal degeneration/necrosis, nerve fiber degeneration, and mononuclear cell infiltration. As AAV vectors become an increasingly common platform for novel therapeutics, non-invasive biomarkers are needed to better characterize and manage the risk of DRG neurotoxicity in both nonclinical and clinical studies. Based on biological relevance, reagent availability, antibody cross-reactivity, DRG protein expression, and assay performance, neurofilament light chain (NF-L) emerged as a promising biomarker candidate. Dose- and time-dependent changes in NF-L were evaluated in male Wistar Han rats and cynomolgus monkeys following intravenous or intrathecal AAV injection, respectively. NF-L profiles were then compared against microscopic DRG lesions on Day 29 post-dosing. In animals exhibiting DRG toxicity, plasma/serum NF-L was strongly associated with the severity of neuronal degeneration/necrosis and nerve fiber degeneration, with elevations beginning as early as Day 8 in rats (≥5×1013 vg/kg) and Day 14 in monkeys (≥3.3×1013 vg/dose). Consistent with the unique positioning of DRGs outside the blood-brain barrier, NF-L in cerebrospinal fluid was only weakly associated with DRG findings. In summary, circulating NF-L is a promising biomarker of AAV-induced DRG toxicity in nonclinical species.
Epilipidomics platform for holistic profiling of oxidized complex lipids in blood plasma of obese individuals
Authors: Criscuolo Angela , Nepachalovich Palina , Garcia-del Rio Diego Fernando , Lange Mike , Ni Zhixu , Blüher Matthias , Fedorova Maria
Published: December 2021

Lipids are a structurally diverse class of biomolecules which can undergo a variety of chemical modifications. Among them, lipid (per)oxidation attracts most of the attention due to its significance in regulation of inflammation, cell proliferation and death programs. Despite their apparent regulatory significance, the molecular repertoire of oxidized lipids remains largely elusive as accurate annotation of lipid modifications is challenged by their low abundance and largely unknown, biological context-dependent structural diversity. Here we provide a holistic workflow based on the combination of bioinformatics and LC-MS/MS technologies to support identification and relative quantification of oxidized complex lipids in a modification type- and position-specific manner. The developed methodology was used to identify epilipidomics signatures of lean and obese individuals with and without type II diabetes. Characteristic signature of lipid modifications in lean individuals, dominated by the presence of modified octadecanoid acyl chains in phospho- and neutral lipids, was drastically shifted towards lipid peroxidation-driven accumulation of oxidized eicosanoids, suggesting significant alteration of endocrine signalling by oxidized lipids in metabolic disorders.
Investing in the Ugandan dairy sector
Authors: Vidal Jorge Fernandez
Published: December 2021

Learning outcomes

Industry analysis and market attractiveness: Understand how to analyse an industry, using the dairy sector in Uganda as an example and what makes a market attractive for incumbents or future entrants. Value disciplines: Understand and apply the different value disciplines companies can choose from to achieve market-leading positions. Business integration: Understand some of the key benefits of vertical integration and when it may or may not make sense to integrate. Doing business in Africa: Understand the specific generic challenges of doing business in Africa, particularly in the agricultural and manufacturing sectors. Generalisability of frameworks: Realise that the same frameworks that are used to analyse large firms and mature markets can be applied to smaller firms in less developed markets.

Case overview/synopsis

The case is set in the early months of 2020, as Bernd Schanzenbächer, founder and managing partner of EBG Capital (a Swiss investment firm that manages a multimillion global portfolio of agricultural investments), and his team are deciding whether to invest in a dairy farm in Uganda. The opportunity looks quite interesting and the EBG Capital team believes there is a good fit between the farm owners’ needs, its management team’s objectives and EBG Capital’s strengths and interests. However, the dairy market in Uganda faces many challenges and, while the market-demand fundamentals appear promising, the team wonders if it is the right time to invest. The issue for EBG Capital is to understand what makes the Ugandan dairy industry so challenging and to determine how to fix or mitigate some of the industry’s most pressing problems – given that it will be the firm’s first investment in the country – as well as for deciding where it makes sense to play in the broad value chain (i.e. only in milk production or also in milk processing).

Complexity academic level

Masters in Business Administration and Executive Education courses.

Supplementary materials

Teaching Notes are available for educators only. Please contact your library to gain login details or email support@emeraldinsight.com to request teaching notes.

Subject code

CSS 11: Strategy.
Managing religion at work: a necessary distinction between words and deeds. A multiple case study of the postures facing religious expression in French organizations
Authors: Gaillard Hugo
Published: December 2021

Purpose

Religious expression at work (REW) has a unique place in France. The authors studied the perception of the postures of four organizations in the face of this phenomenon, focusing on the gap between official posture and the posture applied by managers.

Design/methodology/approach

Using a qualitative approach, the authors conducted semi-structured interviews (40), observation periods and documentary analysis within four organizations. This multiple embedded case study was undertaken in four different firms in France: an international private firm, a public organization, and two small- and medium-sized enterprises (SMEs) with original models of REW management.

Findings

A distinction between aligned and non-aligned postures emerged. There was a lack of alignment in only two of the four organizations, and this alignment concerned only two units of analysis: prayer on break and wearing religious symbols. Several extrinsic factors were identified in this lack of alignment between the official posture and the posture actually applied by managers: the form of REW, the religion concerned and whether it had minority status in the country, the degree of clarity of the official posture, the degree of formalization of the official posture, the size and scope of the company, the degree of awareness of managers and their teams, the degree of involvement of leaders in the definition and implementation of the posture, and the purpose of the official posture.

Research limitations/implications

This research provides a sensitive understanding of religious expression at work and shows that alignment is sought specifically for each form of REW. The distinction between official posture and applied posture is highlighted through the study of perceptions. In addition, this study enables the identification of factors that influence the alignment of official and operational postures.

Practical implications

These results call for clarity of the official posture and for it to be defended by leaders, provision of meaning to postures by raising awareness among intermediate hierarchical lines, understanding of the applicable legal framework to transpose it to the local level, and analysis of unaligned forms of REW to build a strong, shared posture.

Originality/value

This study, which was carried out within a specific French context, concerns areas that have received little attention or have not been studied at all to date, such as REW in SMEs or in the public sector, and demonstrates for the first time the distinction between official postures and effective postures.
Determinants of smallholders’ adoption of mobile phones for vegetable marketing in Vietnam
Authors: Hoang Hung Gia , Nguyen Duc Van
Published: December 2021

Purpose

The purpose of this paper is to examine factors that shape the adoption of mobile phones for vegetable marketing by Vietnamese smallholders.

Design/methodology/approach

A structured questionnaire was given to 185 smallholders randomly chosen from 345 vegetable smallholders in the Vinh Thanh district of Vietnam. Descriptive statistics, inferential statistics and a binary logistic regression were applied to analyse the data.

Findings

The research results show that the smallholders’ adoption of mobile phones for vegetable marketing is significantly affected by their number of extension contacts, distance from smallholders’ homes to local markets, community-based organisation participation, gender, training/credit programme participation, age, education level, income and farm size (χ2 = 143,111, p < 0.000).

Practical implications

A combination of factors related to socio-economic, situational and institutional characteristics of smallholders should be considered when promoting smallholders’ uptake of mobile phones for vegetable marketing in developing nations.

Originality/value

This research provides useful insights into the determinants of mobile phone adoption for vegetable marketing by smallholders and highlights areas that need to be considered when designing policies to improve the uptake of information and communication technologies in developing countries.
Assessing community health governance for evidence-informed decision-making: a cross-sectional study across nine districts of India
Authors: Sharma Shantanu , Rawat Sucheta , Akhtar Faiyaz , Singh Rajesh Kumar , Mehra Sunil
Published: December 2021

Purpose

The authors intend to assess the village health sanitation and nutrition committees (VHSNC) on six parameters, including their formation, composition, meeting frequencies, activities, supervisory mechanisms and funds receipt and expenditures across nine districts of the three states of India.

Design/methodology/approach

The cross-sectional study, conducted in the states of Uttar Pradesh (five districts), Odisha (two districts) and Rajasthan (two districts), used a quantitative research design. The community health workers of 140 VHSNCs were interviewed using a semi-structured questionnaire. The details about the funds' receipt and expenditures were verified from the VHSNC records (cashbook). Additionally, the authors asked about the role of health workers in the VHSNC meetings, and the issues and challenges faced.

Findings

The average number of members in VHSNCs varied from 10 in Odisha to 15 in Rajasthan. Activities were regularly organized in Rajasthan and Odisha (one per month) compared to Uttar Pradesh (one every alternate month). Most commonly, health promotion activities, cleanliness drives, community monitoring and facilitation of service providers were done by VHSNCs. Funds were received regularly in Odisha compared to Rajasthan and Uttar Pradesh. Funds were received late and less compared to the demands or needs of VHSNCs.

Research limitations/implications

This comprehensive analysis of VHSNCs' functioning in the selected study areas sheds light on the gaps in many components, including the untimely and inadequate receipt of funds, poor documentation of expenditures and involvement of VHSNC heads and inadequate supportive supervision.

Originality/value

VHSNCs assessment has been done for improving community health governance.
Supply chain resilience: A review, conceptual framework and future research
Authors: Shishodia Anjali , Sharma Rohit , Rajesh R. , Munim Ziaul Haque
Published: December 2021

Purpose

The study identifies nine important research areas and critically maps the structural relationships among supply chain resilience (SCRES) dimensions, namely, vulnerabilities, capabilities, strategies and performance metrics. The analysis also revealed various influential authors, journals, institutions and trending articles, across SCRES literature.

Design/methodology/approach

This study performs a bibliometric analysis of 771 articles published over the 32 years from 1988 to 2020, and network analysis in combination with content analysis of 90 most cited articles published in research fronts of SCRES.

Findings

The results demonstrate the underlying research areas within the SCRES, which are clustered into nine research themes: (1) conceptual development of SCRES, (2) recent developments of designing resilient supply chain (SC) networks, (3) focus on identifying drivers of SC vulnerability and risks, (4) impact of risks on network resilience, (5) risk assessment to avoid breakdowns/disruptions, (6) measuring resilience approaches/drivers to improve SC performance, (7) building resilient capabilities by integrating other SC dimensions, (8) quantification of SC network and (9) emphasis on developing robustness in SC networks.

Practical implications

This research offers implications for classifying the works in literature based on bibliometric information and network analysis techniques. This can help researchers and practitioners to understand the prominent areas in SCRES and provide guidelines for future research in this area.

Originality/value

This study provides an overview of the evolution of SCRES over time in the domain of supply chain management and also outlines a future research agenda claimed by the trending articles to encourage further investigations in the field of SCRES.
Do school leaders in the Emirate of Abu Dhabi predominantly practice a transformational, transactional, or laissez-faire style of leadership?
Authors: Aldhaheri Ali
Published: December 2021

Purpose

The purpose of this study is to understand the predominant leadership style of school leaders in Abu Dhabi. The leadership style deployed by a school leader affects the performance of the school and its pupils. Methods for identifying the leadership style of school leaders in the UAE have varied, and it is difficult to conclude what the predominant leadership style is. Some studies have sought only to identify a specific leadership style, whilst others have focussed on a particular school type. Changes and improvements cannot be made without an understanding of the baseline leadership style.

Design/methodology/approach

The 36-item multifactor leadership questionnaire (MLQ)5x questionnaire (Bass and Avolio, 2004) is used to quantitatively understand the full range of school leaders’ leadership styles, with 167 respondents from across both public and private schools.

Findings

School leaders predominantly exhibited transformational leadership, practising transactional leadership less frequently and rarely using laissez-faire leadership. This is a positive finding for schools in the UAE; transformational leadership has been shown to result in improved subordinate and organisational performance. Differences between school leaders in public and private schools were tested and are discussed. Dimension reduction techniques were used to assess the structure of the 36-item MLQ5x but did not provide results that met minimum requirements for acceptability. Possible reasons for this are discussed.

Originality/value

To the best of the author’s knowledge, this paper is the first to fully explore and baseline an understanding of the predominant leadership style amongst school leaders in the UAE, identifying the full range of leadership styles – transformation, transactional and laissez-faire – in both public and private schools.
OPC UA TSN: a next-generation network for Industry 4.0 and IIoT
Authors: Trifonov Hristo , Heffernan Donal
Published: December 2021

Purpose

The purpose of this paper is to describe how emerging open standards are replacing traditional industrial networks. Current industrial Ethernet networks are not interoperable; thus, limiting the potential capabilities for the Industrial Internet of Things (IIoT). There is no forthcoming new generation fieldbus standard to integrate into the IIoT and Industry 4.0 revolution. The open platform communications unified architecture (OPC UA) time-sensitive networking (TSN) is a potential vendor-independent successor technology for the factory network. The OPC UA is a data exchange standard for industrial communication, and TSN is an Institute of Electrical and Electronics Engineers standard for Ethernet that supports real-time behaviour. The merging of these open standard solutions can facilitate cross-vendor interoperability for Industry 4.0 and IIoT products.

Design/methodology/approach

A brief review of the history of the fieldbus standards is presented, which highlights the shortcomings for current industrial systems in meeting converged traffic solutions. An experimental system for the OPC UA TSN is described to demonstrate an approach to developing a three-layer factory network system with an emphasis on the field layer.

Findings

From the multitude of existing industrial network schemes, there is a convergence pathway in solutions based on TSN Ethernet and OPC UA. At the field level, basic timing measurements in this paper show that the OPC UA TSN can meet the basic critical timing requirements for a fieldbus network.

Originality/value

This paper uniquely focuses on the specific fieldbus standards elements of industrial networks evolution and traces the developments from the early history to the current developing integration in IIoT context.
Quality 4.0: leveraging Industry 4.0 technologies to improve quality management practices – a systematic review
Authors: Saihi Afef , Awad Mahmoud , Ben-Daya Mohamed
Published: December 2021

Purpose

Quality 4.0 is an emerging research topic concerned with rethinking how quality management needs to be adopted in the digital era. The purpose of this research is to conduct a systematic review on the state of the research in the field of Industry 4.0 impact on improving quality management aspects and how technology can be leveraged to enhance its practices.

Design/methodology/approach

A systematic review of the literature published in the last 5 years is conducted. 52 papers were selected, mapped based on the technology they focused on and categorized based on the addressed quality aspects.

Findings

The review revealed various areas where quality management can benefit from Industry 4.0 technologies, identified several research gaps and suggested new directions for future research. Firstly, the literature provided some insights about industry 4.0 potential contributions but lacks further detail on the exact applications and solutions through use cases and case studies. Secondly, there has been a focus on the potential benefits provided for quality control while there is a clear scarcity in terms of the other quality management tools and methodologies. Thirdly, there is a lack of studies on economic analysis or detailed impacts on quality costs that justifies the substantial investments needed. Finally, there is a need for including more studies about the mapping and integration of ISO 9001 requirements and Industry 4.0 features.

Originality/value

This is the first attempt to conduct a comprehensive review on the ways industry 4.0 technologies can be leveraged for the field of quality management. Based on this review, several directions for further research in this area are identified.
Global study into the pros and cons of ISO 18404: a convergent mixed method study and recommendations for further research
Authors: Antony Jiju , McDermott Olivia , Sony Michael , Powell Daryl , Snee Ronald , Hoerl Roger Wesley
Published: December 2021

Purpose

The paper aims to investigate the pros and cons of having a standard for lean six sigma developed in 2015. The study follows up on a previous study by Antony et al. (2021) in more depth and aims to provide a more detailed investigation of various aspects of the standard.

Design/methodology/approach

A sequential mixed methodology was utilised by interviewing a panel of leading academics and practitioners familiar with lean six sigma followed by distributing a survey questionnaire to continuous improvement and operational excellence (OPEX) personnel.

Findings

The findings indicate that continuous improvement and OPEX professionals have conflicting views of International Standards Organisation (ISO) 18404. A majority of the participants of the qualitative study suggested, whilst supporting the requirement for a lean sigma standard, voiced concerns about the auditability of the standard and whether it is currently “fit for purpose” and proposed that it needs to be revised. Within the quantitative survey, 42% had never heard of the standard, and of the 58% who had heard of it, 90% had read it. Just 10% stated that they had or would apply the standard within their organisations. Just fewer than 50% felt that the standard was fit for purpose which suggests for further refinements of the standard in the future. Finally, 85% of respondents of the quantitative survey suggested for the revision of the standard whilst just 15% felt it should be removed.

Research limitations/implications

Other than a previous study by Antony et al. (2021), implementation of ISO 18404 in organisations and its benefits as well as empirical study looking into the impact of the standard on corporate performance in the literature were limited. An opportunity to review lessons learnt from a case study on the ISO 18404 standard implementation within an organisation would further enhance the research.

Originality/value

The paper provides a valuable resource for organisations to obtain insight into a standard in lean six sigma and whether to implement it or not. Furthermore, the results can form the basis of a case for the future revision of the standard by consolidating and strengthening the findings from the first study with more detailed quantitative and qualitative study.
Examining students' continuous use of online learning in the post-COVID-19 era: an application of the process virtualization theory
Authors: Alarabiat Ayman , Hujran Omar , Soares Delfina , Tarhini Ali
Published: December 2021

Purpose

This study investigated the impact of the virtualization requirements of the learning process on students' satisfaction and their intention to continue using online learning.

Design/methodology/approach

A research model was developed using the process virtualization theory (PVT); it was validated empirically using data obtained from an online questionnaire-based survey of 489 undergraduate students.

Findings

The main results support the role of representation for sensory requirements, sensory requirements, reach, representation for relationship requirements and relationship requirements on shaping students' satisfaction, which all also have a significant influence on students' intention to continue using online learning. Relevance factors are responsible for 61.6% of the variance in students' satisfaction and 83.6% of the variance in their intention to continue using online learning. However, neither the synchronism requirements nor the identification and control requirements had a significant effect on students' satisfaction or on their intention to continue using online learning.

Originality/value

The present research focused on PVT in an online learning context; consequently, a new set of factors that influenced students' satisfaction with and intentions to continue using online learning was empirically tested for the first time. This research contributes to the literature on information systems because it advances the generalizability and applicability of the PVT in a new context and new cultural setting. Moreover, the research apprises researchers and practitioners of new factors, which should be understood and fulfilled to make virtual learning equivalent to the face-to-face learning experience.
A multi-agency approach to reducing harms from violence and aggression directed towards ambulance services staff in Wales (UK)
Authors: Rees Nigel , Rees Patrick , Hough Lois , Parry Dylan , White Nicola , Bowes Brady
Published: December 2021

Purpose

Ambulance services staff worldwide have long been at risk of encountering violence and aggression directed towards them during their work. Verbal forms of violence and aggression are the most prevalent form, but sometimes incidents involve physical injury, and on rare occasions homicides do occur. Exposure to such violence and aggression can have a lasting negative impact upon ambulance staff and has been associated with increased levels of stress, fear, anxiety, emotional exhaustion, depersonalisation and burnout syndrome. Despite the significance of this issue, little progress has been made to tackle it. The purpose of this paper is to describe this multi-agency approach being taken in Wales (UK) to reduce such harms from violence and aggression directed towards ambulance services staff.

Design/methodology/approach

An interpretative post-positivist narrative methodology and policy analysis approach was followed. Snowball methods of gathering data were used to construct this narrative involving meetings, telephone calls, review of policy documents, legislation and academic literature.

Findings

The authors report how tackling violence and aggression directed towards emergency workers has become a priority within Wales (UK), resulting in policy developments and initiatives from groups such as the UK and Welsh Government, the Welsh Ambulance Services National Health Services (NHS) Trust, Health Boards, the NHS Wales Anti-Violence Collaborative and the Joint Emergency Services Group (JESG) in Wales. This has included changes in legislation such as the Assaults on Emergency Workers (Offences) Act 2018 that came into force on 13th November 2018 and policy changes such as the obligatory responses to violence in health care and the JESG #WithUsNotAgainst Us campaign. Our study however reflects the complexity of this issue and the need for further high-quality research.

Originality/value

The experiences and activities of Wales (UK) reported in this paper adds to the international body of knowledge and literature on violence and aggression directed towards ambulance services staff.