bluuebunny/crossref_metadata_2025 huggingface dataset:
Getting genetic ancestry right for science and society
Authors: Lewis Anna C. F. , Molina Santiago J. , Appelbaum Paul S. , Dauda Bege , Di Rienzo Anna , Fuentes Agustin , Fullerton Stephanie M. , Garrison Nanibaa’ A. , Ghosh Nayanika , Hammonds Evelynn M. , Jones David S. , Kenny Eimear E. , Kraft Peter , Lee Sandra S.-J. , Mauro Madelyn , Novembre John , Panofsky Aaron , Sohail Mashaal , Neale Benjamin M. , Allen Danielle S.
Published: April 2022

We must embrace a multidimensional, continuous view of ancestry and move away from continental ancestry categories
Comment on “Impact of neurodegenerative diseases on human adult hippocampal neurogenesis”
Authors: Alvarez-Buylla Arturo , Cebrian-Silla Arantxa , Sorrells Shawn F. , Nascimento Marcos Assis , Paredes Mercedes F. , Garcia-Verdugo Jose Manuel , Yang Zhengang , Huang Eric J.
Published: April 2022

Terreros-Roncal
et al
. investigated the impacts of human neurodegeneration on immunostainings assumed to be associated with neurogenesis. However, the study provides no evidence that putative proliferating cells are linked to neurogenesis, that multipolar nestin
+
astrocytes are progenitors, or that mature-looking doublecortin
+
neurons are adult-born. Their histology-marker expression differs from what is observed in species where adult hippocampal neurogenesis is well documented.
Response to Comment on “Impact of neurodegenerative diseases on human adult hippocampal neurogenesis”
Authors: Terreros-Roncal J. , Moreno-Jiménez E. P. , Flor-García M. , Rodríguez-Moreno C. B. , Trinchero M. F. , Márquez-Valadez B. , Cafini F. , Rábano A. , Llorens-Martín M.
Published: April 2022

Alvarez-Buylla and colleagues provide an alternative interpretation of some of the data included in our manuscript and question whether well-validated markers of adult hippocampal neurogenesis (AHN) are related to this phenomenon in our study. In Terreros-Roncal
et al
., reconstruction of the main stages of human AHN revealed its enhanced vulnerability to neurodegeneration. Here, we clarify ambiguities raised by these authors.
The complexity of chronic pain
The Song of Our Scars: The Untold Story of Pain
Haider Warraich
Basic Books, 2022. 320 pp.
Authors: Meldrum Marcia L.
Published: April 2022

A physician confronts an elusive physical phenomenon
Complex regulation of fatty liver disease
Authors: Ginsberg Henry N. , Mani Arya
Published: April 2022

Hepatic lipogenesis is fine-tuned by mechanistic target of rapamycin (mTOR) signaling
Global project gears up to study vaccine safety
Authors: Couzin-Frankel Jennifer
Published: April 2022

Pandemic propels international efforts to understand incidence of rare side effects
Thermal batteries could back up green power
Authors: Service Robert F.
Published: April 2022

Efficiency jump in key component raises hopes for storing renewable energy as heat
How a site peddles author slots in reputable publishers’ journals
Authors: Chawla Dalmeet Singh
Published: April 2022

Advertisements on Russian website promised to add names to articles that appeared in dozens of journals
In Vitro
Bedaquiline and Clofazimine Susceptibility Testing in Mycobacterium abscessus
Authors: Schulthess Bettina , Akdoğan Kittana Fatma Nur , Hömke Rico , Sander Peter
Published: April 2022

Bedaquiline and clofazimine are increasingly used to treat infections with
Mycobacterium abscessus
. We determined distributions of MICs by broth microdilution for bedaquiline and clofazimine for 61
M. abscessus
clinical isolates using different media and incubation times. We show that incubation time and growth media critically influence the MIC. Our data will aid in defining future clinical breakpoints for
in vitro
susceptibility testing for bedaquiline and clofazimine in
M. abscessus
.
Extracellular Vesicles Regulate Biofilm Formation and Yeast-to-Hypha Differentiation in Candida albicans
Authors: Honorato Leandro , de Araujo Joana Feital Demetrio , Ellis Cameron C. , Piffer Alicia Corbellini , Pereira Yan , Frases Susana , de Sousa Araújo Glauber Ribeiro , Pontes Bruno , Mendes Maria Tays , Pereira Marcos Dias , Guimarães Allan J. , da Silva Natalia Martins , Vargas Gabriele , Joffe Luna , Del Poeta Maurizio , Nosanchuk Joshua D. , Zamith-Miranda Daniel , dos Reis Flávia Coelho Garcia , de Oliveira Haroldo Cesar , Rodrigues Marcio L. , de Toledo Martins Sharon , Alves Lysangela Ronalte , Almeida Igor C. , Nimrichter Leonardo
Published: April 2022

The ability to undergo morphological changes during adaptation to distinct environments is exploited by
Candida albicans
and has a direct impact on biofilm formation and virulence. Morphogenesis is controlled by a diversity of stimuli, including osmotic stress, pH, starvation, presence of serum, and microbial components, among others.
The Leaf Microbiome of
Arabidopsis
Displays Reproducible Dynamics and Patterns throughout the Growing Season
Authors: Almario Juliana , Mahmoudi Maryam , Kroll Samuel , Agler Mathew , Placzek Aleksandra , Mari Alfredo , Kemen Eric
Published: April 2022

Utilizing plant microbiota to promote plant growth and plant health is key to more environmentally friendly agriculture. A major bottleneck in the engineering of plant-beneficial microbial communities is the low persistence of applied microbes under filed conditions, especially considering plant leaves.
Carrier Proteins Facilitate the Generation of Antipolysaccharide Immunity via Multiple Mechanisms
Authors: Zhang Fan , Thompson Claudette , Ma Nicole , Lu Ying-Jie , Malley Richard
Published: April 2022

Polysaccharide capsules, the outermost shells of many bacterial pathogens, play a role in pathogenesis and protect bacteria against the immune system. Generating antipolysaccharide antibodies by vaccination has provided effective protection against infectious diseases caused by encapsulated bacteria.
An Interplay of Multiple Positive and Negative Factors Governs Methicillin Resistance in Staphylococcus aureus
Authors: Bilyk Bohdan L. , Panchal Viralkumar V. , Tinajero-Trejo Mariana , Hobbs Jamie K. , Foster Simon J.
Published: April 2022

The development of resistance to β-lactam antibiotics has madeStaphylococcus aureusa clinical burden on a global scale. MRSA (methicillin-resistantS. aureus) is commonly known as a superbug.
Localized surface plasmon effect on 3-mercaptopropionic acid and citrate stabilized gold nanoparticles for biosensor application
Authors: Pambudi M. T. , Hardianto A. , Yusuf M. , Wulandari P.
Published: April 2022

Herein, we attempt to study the synthesis process of 3-mercaptopropionic acid (3-MPA) capped gold nanoparticles (Au-MPA) and to optimize the preparation of colorimetric sensor based on the localized surface plasmon (LSP) phenomenon compared to the citrate stabilized gold nanoparticles (Au-Citrate). Both Au-Citrate and Au-MPA were prepared using the reduction method. In our case, the product of Au-MPA shows red-wine color of solution with a plasmonic peak at 527[Formula: see text]nm, while Au-Citrate has a plasmonic peak at 519[Formula: see text]nm with the same color of the solution. Both particles have a spherical shape as validated by the TEM image with the average size of Au-Citrate and Au-MPA being 34[Formula: see text]nm and 51[Formula: see text]nm, respectively. Different peak values can be explained by the different size distributions and modified local refractive indices due to the adsorbed ligand on the metal surfaces. Vibrational frequency characterization shows shifting and broadening especially in the region of CO stretching as the result of carboxyl group interaction. Functionalization of AuNPs by the use of biocytin (Biotinylated-AuNPs) shows good stability as revealed with no significant change in the absorbance spectra compared to the AuNP capped by citrate or 3-MPA. The addition of various concentrations of avidin into the assay results in the color changes and the red-shift of the absorbance spectra due to the cross-link aggregation with an intermediate value in the sensing characteristic. This research provides preliminary studies for colorimetric colloidal sensor performances tunability by modifying the adsorbed ligand as the linker between the metal and the bioreceptor.
The Paradoxical Prices of Options
Authors: Marcato Gianluca , Sebehela Tumellano
Published: April 2022

The synchronized relationship between financial and fundamental prices has been topical for years now. It seems that option pricing theory has not been used to disentangle that relationship between two prices during merger and acquisition (M&A) activities. This paper uses Put-Call parity theorem to explore the divergence of financial and fundamental prices in any firm during the acquisition process. The results illustrate that price differentials are persistent; moreover, the differentials are caused by the exponential factor. Despite the fact that some principles are drawn from the real estate investment trust (REIT) literature, the results have wider implications for industries with similar traits to REITs.
Straight-Beam Approach for Analyzing Lateral Buckling of Thin-Walled Curved I-Beams
Authors: Yang Y. B. , Jiang P. X. , Liu Y. Z.
Published: April 2022

The straight-beam approach is a simple and efficient means for analyzing the buckling of curved beams. Although previous researchers showed that the straight-beam approach is capable of simulating the lateral buckling of solid curved beams, the warping effect had been neglected and thus its practical application in engineering was limited. In this study, thin-walled curved I-beams will be dealt with by assuming the warping degrees of freedom (DOFs) to be identical at the common node for non-aligned connected elements. One feature of the present formulation is that the moments induced by initial nodal moments undergoing out-of-plane rotations are duly considered in the geometric stiffness matrix, while the compatibility and equilibrium are enforced for angled joints at the deformed position. With high computational efficiency, the present approach obtains buckling loads that agree well with the theoretical curved-beam solutions or the ones obtained by ABAQUS using shell elements. Compared with the modern curved-beam elements, the straight-beam element is locking free, invariant and simple in formulation, since the effect of curvature is not involved in global assembly.
The Future of the Indo-Pacific
Authors: Xi Guigui
Published: April 2022

With rising geopolitical tensions in the Indo-Pacific, ASEAN is running the risk of becoming a victim of a hegemonic war against China waged by the United States and its Quad partners, a pessimistic scenario for the future of the Indo-Pacific. However, ASEAN has made it clear that ASEAN centrality should play a leading role in shaping the emerging regional architecture. ASEAN’s unique geopolitical position, the ASEAN Way as a special socialization process, and its extensive engaging networks with major powers can help the regional grouping obtain bargaining power to maintain its centrality. Also, the robust China-ASEAN relations can also facilitate ASEAN to maintain its centrality and thus avoid the trap of great power rivalry in the Indo-Pacific.
A new attention-based LSTM model for closing stock price prediction
Authors: Lin Yuyang , Huang Qi , Zhong Qiyin , Li Muyang , Li Yan , Ma Fei
Published: April 2022

Financial time-series prediction has been a demanding and popular subject in many fields. Latest progress in the deep learning technique, especially the deep neural network, shows great potentials in accomplishing this difficult task. This study explores the possible neural networks to improve the accuracy of the financial time-series prediction, while the main focus is to predict the closing price for next trading day. In this paper, we propose a new attention-based LSTM model (AT-LSTM) by combining the Long Short-Term Memory (LSTM) networks with the attention mechanism. Six stock markets indices with four features were used as the input to the model. We evaluate the model performance in terms of MSE, RMSE and MAE. The results for these three metrics are 0.4537, 0.6736 and 0.4858, respectively. The results suggest that our model is skillful in capturing financial time series, and the predictions are robust and stable. Furthermore, we compared our results with the previous work. As a result, our proposed AT-LSTM exhibits a significant performance improvement and outperforms other methods.
Demonstrating Interaction: The Case of Assistive Technology
Authors: Reyes-Cruz Gisela , Fischer Joel E. , Reeves Stuart
Published: April 2022

Technology “demos” have become a staple in technology design practice, especially for showcasing prototypes or systems. However, demonstrations are also commonplace and multifaceted phenomena in everyday life, and thus have found their way into empirical research of technology use. In spite of their presence in HCI, their methodical character as a research tool has so far received little attention in our community. We analysed 102 video-recorded demonstrations performed by visually impaired people, captured in the context of a larger ethnographic study investigating their technology use. In doing so, we exhibit core features of demonstrational work and discuss the relevance of the meta-activities occurring around and within demonstrations. We reflect on their value as an approach to doing HCI research on assistive technologies (AT), for enabling shared understanding and letting us identify opportunities for design. Lastly, we discuss their implications as a research instrument for accessibility and HCI research more broadly.
The Temporal Logic of Coalitional Goal Assignments in Concurrent Multiplayer Games
Authors: Enqvist Sebastian , Goranko Valentin
Published: April 2022

We introduce and study a natural extension of the Alternating time temporal logic
ATL
, called
Temporal Logic of Coalitional Goal Assignments
(TLCGA). It features one new and quite expressive coalitional strategic operator, called the
coalitional goal assignment
operator ⦉ γ ⦊, where γ is a mapping assigning to each set of players in the game its coalitional
goal
, formalised by a path formula of the language of TLCGA, i.e., a formula prefixed with a temporal operator
X
,
U
, or
G
, representing a temporalised objective for the respective coalition, describing the property of the plays on which that objective is satisfied. Then, the formula ⦉ γ ⦊ intuitively says that there is a strategy profile Σ for the grand coalition
Agt
such that for each coalition
C
, the restriction Σ |

C

of Σ to
C
is a collective strategy of
C
that enforces the satisfaction of its objective γ (C) in all outcome plays enabled by Σ |

C

.

We establish fixpoint characterizations of the temporal goal assignments in a μ-calculus extension of TLCGA, discuss its expressiveness and illustrate it with some examples, prove bisimulation invariance and Hennessy–Milner property for it with respect to a suitably defined notion of bisimulation, construct a sound and complete axiomatic system for TLCGA, and obtain its decidability via finite model property.
A Visual Recognition and Path Planning Method for Intelligent Fruit-Picking Robots
Authors: Li Hongli
Published: April 2022

With the rapid development of economy and the increasing improvement of agricultural production level, people’s demand for fruits is also increasing year by year. China is the largest fruit production and consumption country in the world. According to relevant statistics reported for China, by the end of 2019, the total amount of various fruits sold had reached about 270 million tons, with apples accounting for 48% of the global output and pears accounting for 69% of the national total output. However, China’s fruit picking is still dominated by manual picking process, which takes a lot of manpower and time to complete, therefore resulting in low fruit picking efficiency. Some farmers are unable to complete fruit picking in a short time, resulting in a large number of fruits unable to be listed, resulting in huge losses. To solve this problem, this paper focuses on the visual recognition and path planning for intelligent fruit-picking robot. Using robot to complete fruit picking is the best way at present. This paper establishes a picking robot recognition and positioning system based on stereo vision, which is used to identify and locate the fruits planted in the orchard area. The coordinate error of the target point of the intelligent fruit-picking robot coordinate system is less than 10 mm, which has high accuracy. Then, the path of intelligent fruit-picking robot is planned based on visual feedback algorithm and biological stimulation neural network. Our empirical evaluations suggest that the proposed robot walks in the planting park in the shape of “zigzag” and realizes full-coverage path planning after 6 turns. The results show the efficiency of the intelligent method.
Assessing the Fodder Potentials of Drought-Tolerant Maize (Zea mays L.) Hybrids in West Africa
Authors: Amole Tunde , Adekeye Adetayo , Bakare Bazit , Meseka Silvestro , Mengesha Wende , Menkir Abebe
Published: April 2022

The study evaluated the fodder potential of 42 promising drought-tolerant (DT) three-way cross maize (Zea mays L.) hybrids, 11 commercial hybrid checks, and 1 local variety check under irrigation. Agronomic and laboratory trials were conducted to determine their morphological traits and fodder potential. Hierarchical cluster analysis (HCA) to group cultivars into clusters is based on quantity, quality, and the combination of both variables. Selection of potential food-feed cultivars was based on the quantity traits (grain and biomass yield) and quality traits crude protein (CP), in vitro organic matter digestibility (IVOMD), and metabolizable energy (ME). Variation was found for dry matter yield (DMY) at harvest as commercial hybrid recording the maximum DMY of 14.1 t ha−1 and the highest grain yield of 1.4 t ha−1 (P < 0.01), while local check produced a minimum grain yield of 0.54 t ha−1 (P < 0.01) with grain moisture content range between 8.4 and 11.6%. The maximum mean ash content was 5.8% for DT hybrids. Average CP was the highest in commercial hybrids with a value of 6.1%. The mean values for ME were similar (P > 0.01) in both commercial hybrids (7.2 MJ/kg DM) and DT hybrid (7.2 MJ/kg DM), while the highest ME (7.6 MJ/kg DM) was recorded for the local check. Ranking of the hybrids based on grain yield, DMY, CP, ME, and IVOMD showed that cluster subgroup A3 (M1124–24, M1527-7, 30F32, and M1427-6) and A4 (M1427-3, SC637, and M1627-11) exhibited the best potential traits and can therefore be recommended for commercial cultivation following adoption trials by farmers.
Imaging Characteristics and Prognostic Value of Isolated Pulmonary Metastasis from Colorectal Cancer Demonstrated with18F‐FDG PET/CT
Authors: Yu Yu , Zhu Jing , Zhou Yeye , Sang Shibiao , Zhu Yuchun , Zhang Xiaoyi
Published: April 2022

Objective. Solitary pulmonary lesions (SPNs) in patients with a history of colorectal cancer (CRC) may be attributed to metastatic lung tumors, primary lung cancer, or benign nodules. We aimed to analyze the imaging characteristics of SPNs in CRC patients to differentiate these pulmonary nodules and evaluate the prognostic value of isolated pulmonary metastasis from CRC using 18F‐FDG PET/CT. Methods. From January 2013 to January 2021, 62 CRC patients with SPNs demonstrated with 18F‐FDG PET/CT were retrospectively enrolled in the present study. We compared the radiological and clinical characteristics of these patients. In addition, survival time and prognostic factors were statistically analyzed using the Kaplan‐Meier method and multivariable Cox proportional hazards models. Results. There were 33 cases of isolated lung metastasis, 20 cases of second primary lung cancer (SPLC), and nine cases of benign nodules. The proportion of nodules with a maximal diameter greater than the median value was lower in the isolated lung metastasis group compared with the SPLC group (p < 0.05), showing polygonal shape, ill‐defined margin, pleural indentation, air bronchogram, speculation, and ground‐glass opacity. Patients with isolated lung metastasis had a significantly higher maximal diameter of lung lesion, SUVmax of lung lesion, and 18F‐FDG uptake compared with the benign nodule group (p < 0.05). Multivariate analysis revealed that the following two factors were significant independent predictors of PLC: air bronchogram (hazard ratio [HR] =22.327; 95% confidence interval [CI]: 1.910‐261.061; p = 0.013) and spiculation (HR =6.148; 95% CI 1.469‐25.725; p = 0.013). Initial TNM stage IV (HR =19.831, 95% CI 1.061‐370.782; p = 0.046) was extremely associated with a decreased lifespan of CRC patients with isolated lung metastasis. Conclusions. The result showed that CT features, including air bronchogram and spiculated margins, could be used to differentiate SPLC from single isolated lung metastasis in CRC patients. In patients with isolated lung metastasis, primary CRC TNM stage IV was associated with a poorer prognosis, and patients with such conditions might need more care.
Effects of All-Inclusive and Hierarchical Rehabilitation Nursing Model Combined with Acupuncture on Limb Function and Quality of Life in Elderly Patients with Cerebral Infarction during Convalescence
Authors: Zuo Lan , Sun Mingzi
Published: April 2022

Objective. To investigate effects of all-inclusive and hierarchical rehabilitation nursing model combined with acupuncture on limb function and quality of life in elderly patients with cerebral infarction during convalescence. Methods. Eighty elderly patients with cerebral infarction who were treated in our hospital (February 2018–February 2020) and met the inclusion and exclusion criteria were chosen as the research objects, and their materials were analyzed in the way of retrospective study. They were equably randomized into observation group and reference group. Based on the acupuncture treatment, the patients in the observation group and the reference group were given routine rehabilitation nursing and all-inclusive and hierarchical rehabilitation nursing respectively for three months. The simplified Fugl-Meyer Assessment (FMA) scores, Modified Edinburgh-Scandinavian Stroke Scale (MESSS) scores, Activities of Daily Living Scale (ADL) scores, and Stroke-Specific Quality of Life Scale (SS-QOL) scores in the two groups before and after intervention were recorded, and the changes of limb function, neurological function, and living quality of the patients in the two groups were analyzed. Results. Compared with the reference group, the observation group after intervention achieved prominently higher FMA score (

P

 < 0.001), markedly lower MESSS score (

P

 < 0.001), and signally higher SS-QOL scores (

P

 < 0.05). After intervention, the observation group achieved obviously higher ADL score than the reference group (68.88 ± 8.91 vs 59.00 ± 8.38,

P

 < 0.001). Conclusion. The all-inclusive and hierarchical rehabilitation nursing model combined with acupuncture can accelerate the recovery of neurological function of the elderly patients with cerebral infarction, enhance the rehabilitation of their limb function, and markedly improve their quality of life. Therefore, this model has referential significance in clinic.
Correlation between Vaginal Microecological Status and Prognosis of CIN Patients with High‐Risk HPV Infection
Authors: Zhang Huizhen , Jin Shuangling , Ji Aifang , Zhang Chunyan , Shi Shujing
Published: April 2022

Many microorganisms live in the vagina of healthy women. They interact with and compete with the microenvironment in the female vagina to form a dynamic balance of the microenvironment in the female vagina. However, imbalanced vaginal microecology can lead to vaginal resistance to pathogenic microorganisms. Poor capacity can cause women to develop infections of the reproductive tract. This article analyzes the vaginal microecological status of women with high‐risk HPV infection for more than 6 months and healthy women and explores the risk factors that cause long‐term high‐risk HPV infection for timely detection and regulation of possible vaginal microecological imbalance in women with high‐risk HPV infection for more than 6 months to prevent further development of cervical lesions in such patients. This article covers women with a sexual life history who attended the gynecology department of a hospital from January 2020 to September 2021. There were 280 patients in the experimental group: positive high‐risk HPV; and there were 140 patients in the control group: negative high‐risk HPV test. The correlation between vaginal microecology of CIN patients and patient prognosis according to the subject’s vaginal microecology test results and prognosis of various levels of cervical lesions was analyzed. The experiment proved that the detection rate of normal vaginal microecology in the experimental group was 12.14% (34/280) compared with the detection rate of 29.29% (41/140) in the control group, and there was a trend of decrease, and the difference was statistically significant (χ2 = 17.23, P < 0.05). The detection rate of vaginal BV in the experimental group was 10.36% (29/280) compared with the detection rate of 5.0% (7/140) in the control group, and the difference was statistically significant (χ2 = 5.19, P < 0.05). This indicates that women with high‐risk HPV infections for 6 months or longer have a higher incidence of vaginal microecological imbalances than healthy individuals and aggressive vaginal microecological screening. It is necessary to carry out the program. Detect and treat possible abnormal conditions in time to prevent the further onset of the disease.
L-Mesitran Foam: Evaluation of a New Wound Care Product
Authors: Mthanti Segametsi Mary-Jane , Pelle Gloria , Cremers Niels A. J.
Published: April 2022

Chronic wounds are a health problem that has devastating consequences for patients and their quality of life. Often, chronic wounds are stuck in the inflammatory phase or burdened with an infection. Therefore, it is important to find alternative all-round wound care products that have both wound healing and antimicrobial activities. New wound care products are developed constantly, implementing the latest knowledge and advances in wound care. Honey-based wound care formulations and foam dressings are increasingly used in the clinic. L-Mesitran Foam is a novel product in which a foam dressing is precoated with medical-grade honey. Here, we describe our first experiences with L-Mesitran Foam in the clinic. In this case report, a 57-year-old woman with diabetes mellitus type 2 and hypertension presented with a chronic diabetic venous leg ulcer on her leg. Treatments over six months with different treatments, including povidone-iodine, silver dressings, and compression therapy, were ineffective and subsequently switched to L-Mesitran Foam. The dressing choice was based on the wound type and complied with the instructions for use. Wound healing progressed nicely on different aspects and led to complete healing on day 23. No side effects or pain was experienced during treatment. The presented case supports the safety and efficacy of L-Mesitran Foam and serves as a proof of concept.
Accuracy and Reliability of CBCT Compared to Clinical Probing in Detection of Trifurcation Defects: An In Vivo Study
Authors: Alsakr Abdulaziz Mohammad , Creanga Adriana G. , Alqahtani Abdullah Saad , Gufran Khalid
Published: April 2022

Background. Furcation defects are areas of pathological bone resorption in multirooted teeth. The aim of the study was to compare the measurements of trifurcation bone loss, measured using CBCT, versus clinical measurements in order to evaluate the efficacy of CBCT as an adjunctive diagnostic tool. Material and Methods. The included patients had both CBCT scans for maxillary molars and completed periodontal charts. Clinical examination consisted of probing and detection of vertical and horizontal furcation defects. These were measured and recorded. CBCT measurements were then evaluated using the linear measuring tool in Carestream imaging software (Carestream, Rochester, USA) and iCAT (Imaging Sciences, Hatfield, USA). These measurements of the CBCT images were then documented and compared to clinical findings. The two examiners were blinded to each other’s measurements. Results. The most common tooth with a detected furcation defect was tooth #2 (31.7%), followed by tooth #15 (26.8%) and #3 (21.9%). The least common tooth with a detected furcation defect was #14 (19.5%). The mean values of buccal furcation for clinical and CBCT measurements were 3.01 mm and 2.6 mm, respectively. The measurements of mesial furcation were 2.5 mm and 2.2 mm for CBCT. The distal measurement of clinical examination was 2.7 mm and for CBCT was 2.44 mm. Conclusion. CBCT can be used as an adjunct to clinical furcation measurements and adds useful diagnostic information to assess trifurcation defects. In addition, CBCT limited field of view (FOV) can provide relatively high‐resolution images at a reduced dose that is comparable to two‐dimensional imaging.
Sino-Orbital Aspergillosis in a Kidney Transplant Recipient
Authors: Maalouli Christian , De Greef Julien , Duprez Thierry , Devresse Arnaud , Huart Caroline , Coutel Maëlle , Demoulin Nathalie , Belkhir Leïla , Kanaan Nada
Published: April 2022

Sino-orbital aspergillosis is a rare and severe infection mostly seen in immunocompromised individuals in which diagnosis may be challenging with potentially life-threatening consequences. Infection usually starts in the paranasal sinuses with secondary spreading to the adjacent orbits. Here, we report the case of a kidney transplant recipient who presented with proven invasive sino-orbital aspergillosis resulting in irreversible loss of vision despite surgical management and antifungal therapy. We review the literature with a focus on clinical presentation, diagnostic tools, and recommended treatment in the context of kidney transplantation.
Numerical Solution of Schrödinger Equation by Crank–Nicolson Method
Authors: Khan Amin , Ahsan Muhammad , Bonyah Ebenezer , Jan Rashid , Nisar Muhammad , Abdel-Aty Abdel-Haleem , Yahia Ibrahim S.
Published: April 2022

In this study, we implemented the well-known Crank–Nicolson scheme for the numerical solution of Schrödinger equation. The numerical results converge to the exact solution because the Crank–Nicolson scheme is unconditionally stable and accurate. We have compared the results for different parameters with analytical solution, and it is found that the Crank–Nicolson scheme is suitable for the numerical solution of Schrödinger equations. Three different problems are included to verify the accuracy, stability, and capability of the Crank–Nicolson scheme.
Prevalence and Associated Factors of Anemia among Breast Cancer Patients Undergoing Chemotherapy: A Prospective Study
Authors: Muthanna Fares M.S , Karuppannan Mahmathi , Abdulrahman Egbal , Uitrakul Suriyon , Rasool Bassam Abdul Hassan , Mohammed Ali Haider
Published: April 2022

Purpose. The purpose of this study was to ascertain the prevalence and factors associated with anemia (hemoglobin [Hb] 12 g/dL) in breast cancer patients undergoing chemotherapy. Materials and Methods. We conducted a prospective longitudinal study to collect demographic and clinical data on adult breast cancer patients with or without anemia who were admitted to HKL, UMMC, and NCI. The incidence of anemia was determined by detecting whether or not anemia developed during the course of chemotherapy. Mild, moderate, or severe anemia was defined. A chi-squared and logistic regression model were used to assess the effect of demographic and clinical factors on the incidence of anemia and multiple logistic regression analysis was used to evaluate the associations of potential risk factors with the presence of CRA. Results. The study enrolled a total of 292 breast cancer patients. Anemia occurred at a rate of 41.1% (n = 120). Our findings indicated that clinical factors such as the number of chemotherapy regimens, dose reduction, and type of chemotherapy, for example, docetaxel, as well as demographic covariates such as age and BMI, all contribute to the incidence of anemia in cancer patients. Conclusions. According to this study, the prevalence of anemia in breast cancer patients is high. Patients' age, BMI, number of chemotherapy regimens, and docetaxel were risk factors; thus, protocols are needed to identify subgroups of breast cancer likely to benefit from novel management strategies.
Ameliorative Impact of Liraglutide on Chronic Intermittent Hypoxia-Induced Atrial Remodeling
Authors: Wang Jun , Liu Yongzheng , Ma Changhui , Zhang Yue , Yuan Meng , Li Guangping
Published: April 2022

Atrial fibrillation (AF) is the most frequent form of clinical cardiac arrhythmias. Previous evidence proved that atrial anatomical remodeling (AAR) and atrial electrical remodeling (AER) are crucial for the progression and maintenance of AF. This study is aimed at investigating the impact of the glucagon-like peptide-1 (GLP-1) receptor agonist, Liraglutide (Lir), on atrial remodeling (AR) mouse model induced by chronic intermittent hypoxia (CIH). C57BL/6 mice were categorized randomly into the control, Lir, CIH, and CIH+Lir groups. CIH was performed in CIH and CIH+Lir groups for 12 weeks. Lir (0.3 mg/kg/day, s.c) was administered to the Lir and CIH+Lir groups for four weeks, beginning from the ninth week of CIH. Meanwhile, echocardiography and right atrial endocardial electrophysiology via jugular vein, as well as induction rate and duration of AF, were evaluated. Masson and Sirius red staining assays were utilized to assess the extent of fibrosis in the atrial tissue of the mice. Immunohistochemical staining, RT-qPCR, and Western blotting were performed to evaluate the marker levels of AAR and AER and the expression of genes and proteins of the miR-21/PTEN/PI3K/AKT signaling pathway, respectively. ELISA was also performed to evaluate the changes of serum inflammatory factor levels. The CIH group exhibited significant AR, increased atrial fibrosis, and a higher incidence rate of AF compared to the control group. Lir could significantly downregulate the protein expression level in the PI3K/p-AKT pathway and upregulated that of phosphatase and tensin homolog deleted on chromosome ten (PTEN). Moreover, Lir downregulated the expression of miR-21. However, the protein expressions of CACNA1C and KCNA5 in atrial tissue were not changed significantly. In addition, Lir significantly attenuated the levels of markers of inflammation (TNF-α and IL-6) in the serum. In the mouse model of CIH, Lir treatment could ameliorate AR by the miR-21/PTEN/PI3K/AKT signaling pathway and modulation of inflammatory responses.
On New Banach Sequence Spaces Involving Leonardo Numbers and the Associated Mapping Ideal
Authors: Yaying Taja , Hazarika Bipan , Mohamed O. M. Kalthum S. K. , Bakery Awad A.
Published: April 2022

In the present study, we have constructed new Banach sequence spaces

ℓ

p

L

,

c

0

L

,

c

L

,

and

ℓ

∞

L

,

where

L
=

l

v
,
k

is a regular matrix defined by

l

v
,
k

=

l

k

/

l

v
+
2

−

v
+
2

,
 
0
≤
k
≤
v
,

0
,
 
k
>
v
,

for all

v
,
k
=
0
,
1
,
2
,
⋯

, where

l
=

l

k

is a sequence of Leonardo numbers. We study their topological and inclusion relations and construct Schauder bases of the sequence spaces

ℓ

p

L

,

c

0

L

,

and

c

L

.

Besides,

α

-,

β

- and

γ

-duals of the aforementioned spaces are computed. We state and prove results of the characterization of the matrix classes between the sequence spaces

ℓ

p

L

,

c

0

L

,

c

L

,

and

ℓ

∞

L

to any one of the spaces

ℓ

1

,

c

0

,

c

, and

ℓ

∞

.

Finally, under a definite functional

ρ

and a weighted sequence of positive reals

r

, we introduce new sequence spaces

c

0

L
,
r

ρ

and

ℓ

p

L
,
r

ρ

. We present some geometric and topological properties of these spaces, as well as the eigenvalue distribution of ideal mappings generated by these spaces and

s

-numbers.
Tennis Serve Trajectory Capture Algorithm Based on Wavelet Multiscale Decomposition
Authors: Yu Songkun
Published: April 2022

Human motion analysis is one of the important research directions in computer vision technology. Aiming at the problems of poor effect, accuracy, and efficiency in the current tennis serve trajectory capture process, a tennis serve trajectory capture algorithm based on wavelet multiscale decomposition is proposed. This article analyzes the related concepts and principles of wavelet transform and multiresolution analysis, uses the computer three-dimensional vision acquisition method to collect the tennis serve trajectory image, and uses the mean filter to smooth and denoise the collected tennis serve trajectory image. The wavelet multiscale decomposition algorithm is used to process the tennis serve trajectory image after smooth denoising, find the local maximum point through the modulus value and phase angle value, and obtain the initial tennis serve trajectory image. Using the local layer threshold method, the adaptive threshold is set, and the trajectory line under each scale is obtained to capture the trajectory line of tennis serve. It can be observed from the experimental and simulation results that the trajectory capture effect of the proposed algorithm is good, and it can effectively improve the accuracy and efficiency of trajectory capture.
The Effects of City Lockdown Policy on Frozen Embryo Transfer Outcome during COVID-19 Epidemic in Hubei Province, China
Authors: Liao Huiqi , Sun Zhifeng
Published: April 2022

Objective. To evaluate whether there is a difference in clinical pregnancy rate and live birth rate between the corresponding period in 2019 and COVID-19 city lockdown period in 2020 in frozen embryo transfer (FET). Methods. In one single in vitro fertilization (IVF) center (Shiyan, Hubei province, China), a retrospective cohort analysis was conducted, with a sample size of 59 patients in the lockdown period (2020.1.23-2020.2.23, 2020 group) and 34 patients in the corresponding 2019 period (2019.1.23-2019.2.23, 2019 group). Implantation, biochemical and clinical pregnancy, miscarriage, and live birth rates were all measured. Results. Age, basal serum follicle-stimulating hormone (FSH), basal serum luteinizing hormone (LH), basal serum E2, and serum total T were all comparable between the two groups. On the day of progesterone administration, endometrial thickness was similar (

8.5
±
1.3

vs.

8.2
±
1.4

,

P
=
0.356

). The number of transferred blastocysts was not significantly different. The two groups had similar clinical pregnancy rate (61.8% vs. 61.0%,

P
>
0.05

) and live birth rate (47.1% vs. 49.2%,

P
>
0.05

), which did not significantly differ. Nonetheless, there was a significant difference in the cancelled cycle rate between the two groups (0% vs. 28.0%,

P
=
0.043

). Conclusions. Lockdown period FET versus corresponding period FET outcome did not show any significant difference in terms of pregnancy rate and live birth rate between two groups of patients. Although there was no significant difference, in the 2020 group, the live birth rate was higher compared with that in the 2019 group. There was a significant difference in the rate of cancelled cycles due to the seal off control. In summary, artificial endometrial preparation is an appropriate protocol for special periods.
A Multitask Convolutional Neural Network for Artwork Appreciation
Authors: Tian Tian , Nan Feng
Published: April 2022

The computational aesthetics of pictorial art is an important part of human artistic creation, and the computational aesthetics of pictorial art images is a computationally computable human aesthetic process using machines, which has important applications and scientific significance in the automated analysis of large-scale paintings and the computational modeling of perception by machines. To this end, this paper proposes a multitask convolutional neural network model for emotion and rating of artworks. (1) An artwork appreciation dataset consisting of fifty Chinese paintings and fifty Western oil paintings was created, and twenty subjects were recruited to score the art appreciation of one hundred artworks in the dataset, covering both painting aesthetic evaluation and painting emotion evaluation. (2) Based on the artwork art appreciation dataset, an AlexNet-based convolutional neural network model is proposed to utilize the powerful feature extraction and classification capabilities of neural networks to complete artwork art appreciation, and an oversampling method and multitask learning method are used to improve the overall recognition accuracy. (3) Compared with the combination of traditional manual features + machine learning algorithms, the end-to-end multitask convolutional neural network proposed in this paper has the highest accuracy rate of 74.57%/71.43%/74.12%.
Primary Tooth Decay Prevention Program in Children: Application of Intervention Mapping Approach
Authors: Kabiri Bahareh , Heidarnia Alireza , Alavijeh Mehdi Mirzaei , Motlagh Mohammad Esmaeel
Published: April 2022

Background. As the most common diseases globally, oral and dental diseases are closely related to people’s behavior. The present study is aimed at developing a program to prevent primary teeth decay in children using the intervention mapping approach. Methods. This study protocol is aimed at using the intervention mapping approach as the planning framework. The study consists of six steps of intervention mapping, including needs assessment based on the relevant literature review, development of an objectives matrix for changing people’s behaviors and environmental factors, program preparation, program implementation, and program evaluation to develop a family‐centered program. Results. The use of the intervention mapping approach helped us identify the outcomes and functional objectives, develop an appropriate intervention program, and evaluate the program. Conclusions. The intervention mapping approach is an appropriate guide to developing a systematic and evidence‐based program.
Retrospective Observational Study on the Characteristics of Pain and Associated Factors of Breakthrough Pain in Advanced Cancer Patients
Authors: Fan Rongrong , Li Xuying , Yang Siyu , Bu Xiaofan , Chen Yongyi , Wang Ying , Qiu Cuiling
Published: April 2022

Objective. This study aimed to conduct a retrospective observational study to understand the status of characteristics of pain and identify potential variables influencing the clinical presentation of breakthrough cancer pain (BTP) in advanced cancer patients. Methods. Advanced cancer patients over 18 years of age; diagnosed with cancer of any type and stage III or IV in the palliative care ward with available data were enrolled between 2018 and 2020. Demographic data and pain-related information were collected by using structured electronic extraction form from Hospital Information System (HIS). Patients who had well-controlled background pain with an intensity ≤4 on a 0–10 numerical scale for >12 hours/day, the presence of transient exacerbations of pain with moderate-severe intensity (≧5), and clearly distinguish from background pain were regarded to have suffered BTP. Spearman correlation was conducted to explore the relationship between pain score and demographics characteristics. Factors significant in univariate analysis were included in the multiple regression model to explore independent predictive factors associated with the BTP. Results. Of 798 advanced cancer patients, the mean age was 56.7 (SD = 11.84) years. Lung cancer (29.95%) was the most common cancer, and pain (93%) was the most common symptom. More than half (n = 428, 53.6%) of the patients experienced BTP. The median number of BTP episodes was 4 (IQR = 2, 7, range: 1–42). The median intensity of BTP was 6 (IQR = 6, 7, range 5–10). Patients with severe background pain or BTP had longer hospital stay and more symptoms. Besides, more severe background pain was related to higher activity of daily living. Intramuscular injection of hydromorphone hydrochloride was the main medication for BTP onset. Younger age, background pain, anorexia, and constipation were independently associated with the presentation of BTP. BTP pain intensity was independently associated with bloating. Symptom numbers were an independent factor and positively associated with BTP episodes. Conclusions. BTP resulted in poor prognosis, which has a variable presentation depending on interdependent relationships among different characteristics. Good controlling of background pain and assessment of pain-related symptoms are essential for BTP management. BTP should be managed individually, especially the invisible pain among aged patients. Furthermore, BTP-related education and training were still needed.
Construction of Evaluation Model of Tennis Skills and Tactic Level and Application of Grey Relational Algorithm
Authors: Wang Ling
Published: April 2022

Based on the application characteristics of the world’s elite tennis players’ skills and tactics, this paper establishes the evaluation model of skill and tactic level. According to the principle of normal distribution, taking the overall average as the reference value and the overall standard deviation as the discrete distance, the deviation method commonly used in sports statistics is adopted to formulate the grade evaluation standard. The standard is divided into five evaluation grades: excellent, good, passing, poor, and extremely poor. The equivalent evaluation scale of diagnostic indexes of tennis skill and tactic level is established. It also discusses many factors that characterize the skills and tactics of tennis singles. At the same time, it introduces the grey relational algorithm, constructs the evaluation model of skills and tactic level, and makes an example application. Through experimental analysis, it is concluded that this model can be applied not only to the diagnosis of individual athletes but also to the evaluation of a sports team. This article is aimed at further enriching the analysis system of tennis skills and tactics.
A Novel Multiobjective Particle Swarm Optimization Combining Hypercube and Distance
Authors: Shu Xiaoli , Liu Yanmin , Zhang Qian , Yang Meilan
Published: April 2022

The multiobjective optimization problems are a common problem in various fields in the real society. Therefore, solving the multiobjective optimization problems are one of the important problems studied by many researchers in recent years. From the research in recent years, it can be seen that there is still a lot of room for development of particle swarm optimization in solving multiobjective optimization problems. This paper proposes a novel multiobjective particle swarm optimization combining hypercube and distance, called HDMOPSO. The particle velocity update part in this paper uses a combination of hypercube and distance. In order to prevent the algorithm from falling into the local optimum, the part also uses the nonlinear decreasing opposite mutation strategy, which enables the particles to explore a more area. Finally, a control strategy is used for external archive to improve the convergence and diversity of the algorithm. The algorithm has been simulated in 22 test problems and compared with multiobjective particle swarm optimization algorithms (MOPSOs) and multiobjective evolutionary algorithms (MOEAs). The results show that the HDMOPSO can effectively improve the convergence and diversity, so it is an effective improvement.