bluuebunny/crossref_metadata_2025 huggingface dataset:
A RELEVÂNCIA DOS PROGRAMAS DE AUTOCONTROLE NA SAÚDE PÚBLICA EM INDÚSTRIAS DE PRODUTOS DE ORIGEM ANIMAL
Authors:   Hingrid Barbosa de Souza, Silva Gabriel de Souza
Published: October 2024

Self-Control Programs (PACs) are fundamental for the agroindustry, aiming at food safety and reducing risks to public health. Along with Good Manufacturing Practices (GMP), Standard Operational Hygiene Procedures (PPHO) and the Hazard Analysis and Critical Control Points Program (HACCP). The research aims to demonstrate the importance of PAC as a tool capable of minimizing and controlling levels of contamination, infection and/or food poisoning in the food industry, discussing the regulations issued by supervisory authorities on the quality, health and safety of food, as well as good practices in the production of products of animal origin. The importance of studying this topic is that it has great relevance due to the fact that it addresses the importance of the hygienic-sanitary and technological quality of raw materials, animal health and public health. The study was carried out using articles, books and academic sources through electronic searches in SciELO, Google Scholar, PUBMED, PubVet of relevance in addition to Laws and books, bibliographical research and insights into the need to highlight and demonstrate the importance of programs in the food industry. It was concluded that PACs are essential to reduce risks to public health and enhance food quality and safety for consumers.
LAWFARE NA POLÍTICA BRASILEIRA E SEUS REFLEXOS NA SOCIEDADE
Authors: Zaleski Jair , Kupicki Katia
Published: October 2024

This article aims throughout its contents to promote the understanding and prominence of Lawfare, highlighting how this process occurs and its main impacts on legal and electoral, as well as social, aspects. The general objective of this is to highlight the main characteristics of Lawfare. Regarding the specific objectives, these are: contextualize Lawfare; highlight Lawfare in the Brazilian reality; evaluate the main consequences and difficulties regarding the Lawfare process within the Brazilian social routine. For better stability of the information, data and aspects covered throughout the article, a literature review was carried out, highlighting some of the main concepts and analyzes by renowned authors, based on works published over the last 8 years. It can be concluded that there are some aspects within the Brazilian political field that can have a considerable impact on society as a whole, as well as some rights considered in the Constitution to be fundamental for an efficient social and political environment.
ANÁLISE DE UM MEDIDOR DE TOTAL DISSOLVED SOLID SENSOR DE CONDUTIVIDA E DE NÍVEL DE AGUA DE OSMOSE REVERSA COM ARDUÍNO
Authors: SOUZA, Bruno Santos , PACHECO, Maria dos Anjos Fernandes
Published: October 2024

Introdução:  medidor de TDS, sensor de condutividade e sensor de nível de água para osmose reversa com Arduino é um sistema integrado que monitora a qualidade da água em tempo real. O sistema é automatizado, emitindo alertas visuais e sonoros quando os parâmetros ultrapassam limites críticos. Objetivo geral: analisar um protótipo medidor de TDS sensor de condutividade e de nível de água de osmose reversa com arduíno. Metodologia: o presente estudo trata-se que um estudo de caso do tipo onde foi realizado um protótipo funcional que monitore a qualidade da água através de um medidor de TDS e sensores de nível de água, utilizando a plataforma Arduino para controle e automação. Resultados: os dados revelam uma precisão satisfatória nas medições, com variações mínimas em comparação com soluções padrão. O sistema de alerta foi eficaz, acionando alertas sonoros e visuais em situações de níveis críticos de TDS e de água. Os testes demonstraram que o sistema automatizado melhorou a resposta a condições adversas, minimizando riscos de falhas operacionais. A integração de dados históricos permitiu a identificação de padrões e tendências na qualidade da água. Conclusão: O sistema apresentou precisão nas medições e respostas rápidas a condições críticas, garantindo maior controle no processo de osmose reversa. A automação implementada reduziu a necessidade de intervenção manual e aumentou a segurança operacional. Com ajustes de calibração e manutenção preventiva, o protótipo se mostrou uma solução viável e eficiente para aplicações no tratamento de água.
Desmembramento constitucional: considerações críticas
Authors: Megali Neto Almir
Published: October 2024

Este artigo apresenta considerações críticas ao conceito de desmembramento constitucional. Como método, utiliza a revisão da literatura para expor o modo como Richard Albert define e situa o conceito, criticado por Carlos Bernal Pulido, Yaniv Roznai e David Landau. Em seguida, apresenta nossas objeções à validade do desmembramento constitucional, com o fim de demonstrar sua incapacidade para lidar tanto com os fenômenos que descreve quanto com seus próprios intentos, já que não inova nem ultrapassa a teoria clássica do poder constituinte e a doutrina tradicional das emendas constitucionais inconstitucionais. O trabalho encerra-se com um alerta sobre o impacto daquele conceito no constitucionalismo democrático.
A retenção dolosa de salário segundo a Constituição: perfil dogmático e de política criminal
Authors: Kalil Hugo Souto
Published: October 2024

A Constituição determina a criminalização da retenção dolosa de salário. Porém, passadas mais de três décadas desde sua promulgação, a lei necessária para tipificar o crime ainda não foi editada pelo Congresso Nacional. Baseado nos anais da Assembleia Nacional Constituinte de 1987-1988, este artigo considera aspectos constitucionais e de política criminal envolvidos no debate sobre a criminalização da retenção dolosa de salário. Conclui que o constituinte originário se manifestava pela aplicação do crime de apropriação indébita nos casos de retenção dolosa de salário e que o legislador ordinário teria liberdade para regular a matéria, mas deve conciliar o mandado de criminalização com a proibição da prisão civil por dívidas.
A geografia dos ambientes institucional e organizacional da inovação: um reforço das desigualdades regionais no Brasil?
Authors: Memória Caroline Viriato
Published: October 2024

Este estudo analisa a geografia dos ambientes organizacional e institucional da inovação no Brasil. A hipótese é que ela reforça a concentração geográfica da inovação e as desigualdades regionais. O método utilizado é o hipotético-indutivo, ancorado em análise crítica e propositiva de conteúdo, com pesquisa em fontes bibliográficas, documentais e dados secundários desagregados regionalmente obtidos em fontes oficiais, como o Ministério da Ciência, Tecnologia e Inovação. Quanto à abordagem, a metodologia é quali-quantitativa; quanto à natureza, é teórica e empírica; e quanto aos objetivos, é descritiva e explicativa. A investigação constata a necessidade de incentivos mais bem distribuídos destinados à redução das desigualdades regionais, por meio de melhorias na configuração geográfica dos ambientes institucional e organizacional da inovação.
Interview: Sue Phillips on Al Jazeera International’s First Year
Authors: Weyman George
Published: October 2024

George Weyman: Al Jazeera English started with the mission of reversing the news flow in the world from south to north. Have you succeeded in that mission and how is that mission developing? Sue Phillips: I think we have succeeded in reversing the flow of information from south to north, that was the mission and vision of Al Jazeera English when we first launched, and we launched in November last year, a very successful launch. That and lots of other things we set out to do I think we actually achieved, I mean it sounds rather glib, but I think we have. Including covering the developing word which was one of or missions as well and I think we have done that quite successfully over the last eight months.
That Joke isn’t Funny Anymore: Bass Mat Watan’s Nasrallah skit and the limits of laughter in Lebanon
Authors: Haugbolle Sune
Published: October 2024

Shafiqa was certainly not the kind of television host Lebanese viewers would expect to see interviewing a major political figure. Dressed as a woman and with a silly, effeminate voice a la Mickey Mouse, he was anything but the image of a serious TV presenter. So it would be all the more startling for Lebanese audiences to witness this newscaster host the most controversial political leader of them all: Hizbullah head Hassan Nasrallah. But this is what they were apparently witnessing as they switched to Lebanese satellite channel LBC on 1 June 2006. Shafiqa welcomes the viewers to the show and remarks that some people might be surprised to see Hassan Nasrallah beside him, to which Nasrallah retorts: “Why would people say that? Has anyone said that we [Hizbullah] eat people?” “Well,” says Shafiqa, “every time Your Honor appears in the media, you say, ‘we will chop off their hands, break their necks and grind their stomachs.’” “That’s tactics, Shafiqa, part of the balance of terror,” Nasrallah explains with a wave of his hand. “Do people think that we will open a butcher shop and sell ground meat and hamburgers?” Nasrallah wraps up the interview declaring that Hizbullah will not lay down its weapons after liberating the Shebaa Farms, but will instead move on to its next target: the occupied territories of Abu Hassan, a Lebanese in Detroit, whose Jewish American neighbor has invaded his garden.
Bravely Stating the Obvious: Egyptian humor and the anti-American consensus
Authors: Armbrust Walter
Published: October 2024

Over slightly more than the past decade a number of mass mediated Egyptian comedies have depicted and criticized the United States. American. journalists report on these productions with regularity, usually labeling them as straightforward manifestations of anti-Americanism, and often conflating anti-American, anti-Israeli, and anti-Semitic speech of all types. Many of these reports argue that anti-Americanism is unrelated to American and Israeli actions, and is actually caused by mass media, or at least inflamed by it to the point that whatever actual objections Egyptians may have to American policies are irrelevant. This argument is particularly salient in American neoconservative publications over the past decade. American neoconservatism has in turn become closely allied with Zionist—particularly Likudist—political positions. Neoconservative/Zionist organizations actively seek to shape American perceptions of undifferentiated anti-Americanism in Middle Eastern media through well-funded media monitoring operations such as the Middle East Media Research Institute (MEMRI). A few years ago Egyptian media portrayals of the United States were a topic of great interest for many Americans and Europeans, or at least I thought so because I was often asked to comment on it. More recently requests for information or analysis on the topic of anti-Americanism in Egyptian media seem to have subsided. There are a number of possible reasons for this. One of these is that attributions of anti-Americanism and anti-Semitism in Egyptian media have become so normative for Americans that the issue has simply receded into the background as a form of received wisdom. In other words, the neoconservative/Zionist narrative of state-controlled media instilling anti-Americanism is so dominant that nobody thinks to question it. Hence it no longer qualifies as a "story" for journalists or political scientists. Another possibility is that perhaps the Iraq war has simply displaced all other issues raised by American relations with countries of the Middle East. Perhaps the question of "what do Egyptians (and Arabs) make of the United States" no longer seems pressing due to the intensity of American engagement in Iraq.
Kerangka Kerja Scrum
Authors: Hanapi Ade Musyra , Hermanto Rico
Published: October 2024

Semakin majunya industri-indusri di dunia maka semakin banyak manusia yang berinovasi dan kualitas personal individu itu sendiri. Kita menyadari bahwa dunia terus berubah dan setiap perusahaan harus terus berinovasi untuk dapat bersaing, maka itulah penerapan manajemen di sebuah perusahaan tidak boleh kaku dan stagnan. Manajemen perusahaan harus semakin berubah kearah yang lebih baik, sesuai dengan perkembangan perusahaan dan perkembangan dunia. Ditambah lagi, dengan teknologi yang semakin maju, perusahaan harus pandai memanfaatkan teknologi yang ada dalam manajemen perusahaannya, serta sumber daya manusianya dalam membentuk suatu tim kinerja yang baik. Unsurunsur yang terkait dalam kerangka tim kerja guna meningkatkan kinerja karyawan seperti, kesetiaan, prestasi kerja, tanggung jawab, ketatan, kejujuran, kerjasama, prakarsa serta kepemimpinan. Kerangka kerja scrum banyak digunakan oleh sebagian perusahaan di Indonesia, adapun manfaat penggunaan kerangka tersebut adalah untuk mengevaluasi kerangka kerja tim perusahaan yang selama ini telah berjalan, untuk memaksimalkan fungsi-fungsi manajemen berupa perencanaan, pengorganisasian, kepemimpinan, dan pengontrolan dalam tim, untuk meningkatkan efisiensi kinerja tim dalam perusahaan. Bila semua itu terwujud maka sumber daya manusia akan semakin berkualitas.
BLBI (Bantuan Likuiditas Bank Indonesia), Kebijakan Berbalut Pelanggaran Etika Profesi Bankir
Authors: Kasih Ekawahyu , Haryanto Rudi , Panilih Veronika Rayung
Published: October 2024

Bank Century dari kasus BLBI (Bantuan Likuiditas Bank Indonesia), dana talangan atau baillout yang diindikasikan oleh Indonesia Corruption Watch (ICW) dan lembaga terkait serta hasil audit BPK (Badan Pemeriksa Keuangan) yang mengatakan ada penyelewengan sekitar 138,4 Triliun Rupian. Dalam sudut pandang moral dikatakan bahwa mengejar keuntungan merupakan hal yang wajar, asalkan tidak tercapai dengan merugikan pihak lain. Jadi, ada batasnya juga dalam mewujudkan tujuan perusahaan. Dari hasil pembahasan dapat ditarik sebuah kesimpulan yang mengindikasikan bahwa pengucuran dana talangan atau baillout yang diberikan oleh Bank Indonesia pada awalnya merupakan sesuai dengan teori-teori etika dan prinsip keadilan baik keadilan menurut pandanganklasik ataupun keadilan menurut pandangan modern, namun pada penyalurannya terdapat fakta-fakta yang mengarah pada tindak korupsi, kolusi, dan nepotisme yang dilakukan oleh para pejabat Bank Indonesia dan pimpinan bank-bank umum. Sebagai saran sebaiknya para pejabat yang memangku jabatan dalam pemerintah baik itu dalam level eksekutif, yudikatif, ataupun legislatif menarik diri dari permasalahan yang mengarah pada judgment masyarakat umum, yang berasumsi pada tindak korupsi, kolusi, dan nepotisme
ИСТОРИКО-ПРОСВЕТИТЕЛЬСКИЙ ФАКТОР В ПЕРЕВОДЕ КАЗАХСКОГО АЛФАВИТА НА ЛАТИНИЦУ
Authors: Каринов Аблай , Утепов Марат , Аллагулов Артур
Published: October 2024

This article is dedicated to the issue of the transition of the Kazakh alphabet from Cyrillic to Latin script. The article provides a review of the literature on the influence of Soviet ideology on education in general and on the influence of this ideology on the two changes in the Kazakh alphabet in the first half of the twentieth century. From our point of view, the modern approach is more flexible, scientific, and consistent with the process of Romanization in neighboring Turkic-speaking countries. We also took into account the position of Russian researchers interested in the problems of education policy in this area. It was important for us to analyze possible didactic and methodological problems associated with the introduction of Latin graphics into the educational sphere, since the education and development of children is a priority task of our society. Further, the collected data will be compared with the policy of translating the modern Kazakh alphabet into Latin and with programs such as “Spiritual Renewal” and “100 new books”. The research methods of the survey are (historical) observation and content analysis. The data were collected through a short-term review. The study results conclude that changing the alphabet twice in eleven years during the Soviet period is less effective and scientific than the current policy of translating the Kazakh alphabet into Latin.
The Impact of Financial Development and Green Financing on Economic Growth: An ARDL Estimation
Authors: Sana Gull, Tamsila Farid, Zunaira Maqsood
Published: October 2024

This research investigates the influence of financial development and green financing on Pakistan's economic growth. Financial development is assessed through two sub-dimensions: financial value added by manufacturing and financial value added by services. Additionally, population and education serve as control variables to assess their impact on economic growth. Data from 1990 to 2020 was utilized for analysis using EViews v10 in Time series. Statistical tests including descriptive statistics, F-bound cointegration tests, and ARDL models were employed to test hypotheses. Diagnostic tests were also conducted to ensure data clarity and generalizability. The findings reveal that financial development positively and significantly affects economic growth in both the short and long run. Moreover, green financing demonstrates a positive and significant impact on long-term economic growth but remains insignificant in the short term. Findings suggest that fostering financial development, and integrating green financing initiatives into economic policies can further bolster sustainable development efforts, aligning with global environmental goals. Policymakers can use these insights to design targeted strategies aimed at leveraging financial sector growth and sustainable financing practices to enhance Pakistan's economic resilience and prosperity. Nevertheless, this study is limited by its focus solely on Pakistan, with only 31 yearly observations. Future research could enhance the study's applicability by utilizing panel data from various countries.
Corporate Environmental Ethics: Catalyst for Green Innovation and Business Performance in Pakistan's Healthcare Manufacturing Sector
Authors: Ayesha Yaseen, Saira Arshad, Sharaf Salem Mohammad Al-Hyasat
Published: October 2024

This empirical study investigates the intricate relationships between corporate environmental ethics, green innovation, and business performance within Pakistan's healthcare manufacturing sector. Utilizing survey data from 30 manufacturing firms, the research examines how green innovation impacts financial and environmental performance, with a specific focus on the mediating role of corporate environmental ethics. Furthermore, the study explores the moderating influence of environmental uncertainty on the relationship between green innovation and success in economic and environmental domains. Results indicate that robust corporate environmental ethics significantly enhance environmental performance, while green innovation coupled with such ethics contributes positively to economic performance. Moreover, environmental uncertainty moderates the effects of green innovation on both economic and environmental performance outcomes. These findings offer valuable insights for decision-makers aiming to navigate the complexities of sustainable business practices, particularly within the context of Pakistan's healthcare manufacturing sector.
Green Intellectual Capital Driving Environmental Performance: The Mediating Role of Green Ambidexterity and Moderating Influence of Environmental Ethics
Authors: Kiran Fatima, Aansa Ahmed, Mahnoor, Ali Haider Sultan
Published: October 2024

This empirical investigation explores the relationship between Green Intellectual Capital (GIC) and Environmental Performance (EP) within Pakistan’s pharmaceutical industry. Employing quantitative methods and data form 286 respondents, findings reveal a positive correlation between GIC and EP. The significant and positive association between GIC and Green Ambidextrous Innovation (GAI) unveils a novel pathway for leveraging intellectual capital to foster innovation in environmentally sustainable practices within organizations. Moreover, the study underscores the pivotal role of GAI in enhancing EP, emphasizing its potential as a catalyst for environmental performance improvement. The observed moderating effect of GAI on the relationship between GIC and EP highlights the importance of cultivating ambidextrous capabilities to fully harness the benefits of intellectual capital for environmental sustainability. Additionally, the interaction between Environmental Ethics (EE) and GAI reveals s strong effect, underscoring the significance of ethical considerations in shaping organizational responses to environmental challenges. These findings offer valuable insights for scholars and industry practitioners, informing strategies for enhancing environmental performance and competitive advantage in the pharmaceutical sector, while contributing to the academic discourse on green innovation and corporate sustainability.
Raising the Flag of Vigilance on Mpox Outbreak in Indonesia: Are We Prepared?
Authors: Adnyana I Made Dwi Mertha , Maulana Sidik , Lutfian Lutfian , Adiwinoto Ronald Pratama
Published: October 2024

In the wake of the COVID-19 pandemic, the world has become acutely aware of the devastating impact of infectious diseases on public health, economies, and societies. As we gradually recover from the aftermath of COVID-19, another potential threat looms on the horizon, mpox, formerly known as monkeypox. The recent surge in mpox cases worldwide has prompted health authorities to sound an alarm, and Indonesia, as a populous nation with a complex healthcare system, must ask itself: Are we prepared for this emerging challenge?. The question "Are we prepared?" may not have a simple yes or no answer. Instead, it should serve as a reminder of the need for vigilance, adaptation, and continuous improvement in public health systems. As we navigate this new health challenge, the true measure of Indonesia's preparedness is its ability to respond swiftly, effectively, and equitably to protect the health and well-being of all citizens.
Aplikasi Informasi Penerimaan Siswa Baru Di Sekolah Islam Plus Baitussalam Berbasis Android Menggunakan Android Studio (Studi Kasus Sekolah Islam Plus Baitussalam)
Authors:   Universitas Islam Al-Ihya Kuningan, Dewi Sonia Gina , Siti Kurniasih Neneng
Published: October 2024

Penerimaan siswa baru merupakan salah satu proses yang ada di instansi pendidikan seperti sekolah, proses sistem pendaftaran siswa baru di sekolah islam plus baitussalam masih bersifat manual dimana harus mengisi formulir pendaftaran dengan yang diserahkan oleh panitia pendaftaran, sehingga calon siswa baru harus datang ke sekolah dan membutuhkan waktu yang lama. Android dapat digunakan dalam pengembangan sistem dimana calon siswa baru dapat menginput data melalui samrthpone. Metode yang di gunakan dapat menyesuaikan terhadap perubahan yang ada pada penerimaan siswa baru bebasis android dengan menggunakan android studio adalah memudahkan calon siswa baru melakukan pendaftaran di sekolah islam plus baitussalam secara online dan dapat menyesuaikan terhadap perubahan yang ada calon siswa baru dengan fitur layanan home, jadwal pendaftaran, data pendaftaran formulir pendaftaran dan persyaratan pendaftaran, sehingga dapat memudahkan dalam mengelola data calon siswa baru yang mendaftar di sekolah islam plus baitussalam dan informasi pengumuman penerimaan calon siswa baru.
Self-Reported Zoom Exhaustion and Fatigue Levels among Physical Education Teacher Education Students in a State University in the Philippines
Authors: Tolentino Julius Ceazar , Miranda John Paul
Published: October 2024

The study determined the self-reported Zoom exhaustion and fatigue (ZEF) levels of physical education teacher education (PETE) students in the Philippines who are attending a flexible learning setup (i.e., synchronous and asynchronous learning) offered by their university as a solution to continue classes during the coronavirus disease (COVID)-19 pandemic. Utilizing a cross-sectional comparative research design, the study indicates that PETE students were very tired and exhausted both in general and visually after a series of video conferencing within a semester. Furthermore, they were socially-, motivationally-, and emotionally- moderately tired and exhausted. It was observed that students in the PETE program experienced moderate to very tired and exhausted levels of fatigue whenever they participated in synchronous online classes, such as attendance at a video teleconferencing platform. Exploration of how specific mental aspects relate to their general health with regard to their culture and habits is worth exploring, either for students, teachers, or professionals in general.
Gender Differences in School Achievement and Attitudes towards Motivation in Secondary Economic Education
Authors: Novák Jaromír , Berková Kateřina , Kubišová Andrea , Kolářová Dana
Published: October 2024

Abstract: This study examined the school achievement and attitudes of Czech and Slovak secondary school students (n = 572; age: 17-19) towards motivation in economic subjects. The aim was to analyse the factors of students’ motivation, their relations with selected teacher’s competences, and students’ school achievement with regard to their gender. The data were obtained by using a questionnaire and analyzed by Mann-Whitney U-test, Pearson, and Spearman correlation coefficients. Girls performed better than boys in all the subjects analysed. At the same time, for all factors of motivation with significant gender differences, their motivation was stronger compared to boys. School achievement and attitudes towards selected motivation factors are correlated. Some factors motivating boys with better achievement motivate girls with worse achievement.
Side Effects of Some Insecticides and Acaricides on Different Beneficial Insects in Laboratory Conditions
Authors: Kahya Doğancan , Tireng Karut Şebnem , Doğru Ahmet , Görür S. Emre
Published: October 2024

Side effects studies are important for the development of Integrated Pest Management (IPM) strategies, especially due to the adverse impacts of broad-spectrum pesticides on natural enemies. This study was conducted to evaluate the side effects of commonly used pesticides on Chilocorus bipustulatus L. (Coleoptera: Coccinellidae), Anagyrus pseudococci (Girault) (Hymenoptera: Encyrtidae), and Amblyseius swirskii Athias-Henriot (Acari: Phytoseiidae) under laboratory conditions. The results revealed varying mortality rates among the natural enemies, with Abamectin exhibiting the highest mortality rates of 65.00%, 71.50%, and 78.75% respectively. Spirodiclofen (S1) showed the lowest mortality rate of 17.50% for C. bipustulatus, while Buprofezin (B) and Spirodiclofen (S2) showed rates of 18.78% and 18.93%, respectively for A. pseudococci. For A. swirskii, Spirodiclofen (S1 and S2) recorded the lowest mortality rates of 21.25% and 23.75% respectively. According to the IOBC classification, Spirodiclofen (S1 and S2) was classified as harmless (N,) against all three natural enemies. Abamectin (A) was classified as slightly harmful (M) for all three species, while Buprofezin was rated as slightly harmful (M) for C. bipustulatus but harmless (N,) for A. pseudococci and A. swirskii. This research highlights the differential effects of pesticides on different natural enemies and underlines the importance of considering such impacts in pest management strategies.
Comparison of different fertilization rates on yield, evapotranspiration, and water use efficiency of sweet corn under drought-salinity stresses
Authors: Kiremit Mehmet
Published: October 2024

The present study investigated the effects of three fertilization (N-P2O5-K2O) rates (F1: 240-100-120 kg ha-1, F2: 192-80-96 kg ha-1, F3: 154-64-77 kg ha-1) coupled with four irrigation practices (Control: C, irrigated at the 100% field capacity, Drought: D, irrigated 60% of C, Saline: S, irrigated at the 100% field capacity, Drought and saline: D+S, irrigated 60% of S) on sweet corn yield, evapotranspiration (ET), water use efficiency (WUE), and shoot fresh-dry weights. The obtained results depicted that the grain yield at D, S, and D+S treatments decreased by 24.2%, 46.6%, and 62.0%, respectively, relative to the C treatment. Moreover, grain yield at the F3 condition was reduced by 45.3% compared to the F1 condition. Additionally, the highest ET (330.7 mm) and yield (74.0 g) was achieved with F1×C treatment. The F2 and F3 treatments reduced WUE by 17.9% and 31.5%, respectively, compared to the F1 treatment. The highest reduction in yield, ET, WUE, and shoot fresh-dry weights was found at D+S irrigation treatment under all fertilization conditions. The tallest plants were observed in the F1×C treatment, being 24.0%, 33.5%, and 43.2% taller than plants in the F1×(D+S), F2×(D+S), and F3×(D+S) treatments, respectively. Under F3 conditions, exposing sweet corn plants to single or combined salinity and drought stress remarkably degraded the growth ability of the plants, and therefore, it is not economical and sustainable cultivation for agriculture. Finally, cultivation of sweet corn plants under individual or combined drought-salinity stress is not recommended due to the high reduction in grain yield.
The Power of Petition in Altering the Postal Routes of Rural Ontario
Authors: Martinello Christopher S.
Published: October 2024

In the late nineteenth-century, rural post offices linked settlers to the rest of Canada and, indeed, the world. But such offices also allowed them to petition the Post Office itself particularly when it came to influencing the mail routes connecting remote hamlets to each other. This article examines the petitions submitted by settlers in the Haliburton region of Ontario in attempts to affect mail routes. They used the changing significance of villages in Haliburton County as their main motivation when petitioning. In areas without railroads, settlers used the poor state of colonization roads and local business interests to strengthen their arguments for change. The records also reveal that rural postmasters contended against each other to ameliorate their own hamlets. Understanding the social forces that influenced mail routes can enhance our perspective of the changing nature and role of the Post Office in the late nineteenth century.
Investigation of the antimicrobial efficacy and cytotoxicity of a natural disinfectant Syzygium cumini (L.) skeels leaf extract on vero cell lines
Authors: Devi Haorongbam Joldy , Gnanasekaran Prathiba , Devi Yumnam Asha , Siva Durairaj , Jayashankar Jaihitashee
Published: October 2024

Disinfectants are vital for infection prevention and environmental health maintenance. However, the use of chemical disinfectants has adverse effects on human health, including the development of antibiotic-resistance genes and resistance to disinfectants due to overuse and abuse. There is a critical need to find natural alternatives to reduce the problems caused by chemical disinfectants. The present study analyzed the antimicrobial activity of Syzygium cumini leaf extract (SCLE) against Staphylococcus aureus, Pseudomonas aeruginosa, Mucor sp., Candida albicans, and Aspergillus niger and its efficacy as a natural disinfectant was also evaluated, along with GC-MS analysis and in vitro toxicity test. The study showed that SCLE exhibited antimicrobial activity against all test organisms except A. niger. The minimum inhibitory concentration (MIC) against S. aureus, P. aeruginosa, Mucor sp., and C. albicans was 625, 1,250, 78, and 1,250 μg/ml, respectively. The minimum bactericidal concentration (MBC) against S. aureus and P. aeruginosa was 1,250 and 2,500 μg/ml, respectively. The minimum fungicidal concentration (MFC) against Mucor sp. and C. albicans was 156 and 5,000 μg/ml, respectively. SCLE demonstrated bactericidal and fungicidal properties based on MIC: MBC and MIC: MFC, with significant reductions in P. aeruginosa (99.99%), S. aureus (90.71%), Mucor sp. (92%), and C. albicans (73.45%) after the treatment. Syzygium cumini leaf extract, identified as nontoxic with an IC50 of 320μg/ml, proves promising as a potent natural disinfectant. This study marks the first report on the efficacy of S. cumini leaf extract against test organisms, showcasing its potential as a natural disinfecting agent against test organisms.
Tecnologias vestíveis: memória e intimidade sobre o corpo
Authors: Mendes Duque Thatiane
Published: October 2024

Este livro investiga as interações entre corpo, roupa e tecnologias vestíveis. Para tanto, a obra propõe tessituras sobre memória, autobiografia e intimidade. Ao discutir as tecnologias vestíveis, como relógios inteligentes e óculos de realidade virtual ou aumentada, o texto se propõe a pensar de que maneiras a tecnologia permite a ressignificação contínua do contato, do afeto e do desejo.
Discriminating neural ensemble patterns through dendritic computations in randomly connected feedforward networks
Authors: Somashekar Bhanu Priya , Bhalla Upinder Singh
Published: October 2024

Co-active or temporally ordered neural ensembles are a signature of salient sensory, motor, and cognitive events. Local convergence of such patterned activity as synaptic clusters on dendrites could help single neurons harness the potential of dendritic nonlinearities to decode neural activity patterns. We combined theory and simulations to assess the likelihood of whether projections from neural ensembles could converge onto synaptic clusters even in networks with random connectivity. Using rat hippocampal and cortical network statistics, we show that clustered convergence of axons from three to four different co-active ensembles is likely even in randomly connected networks, leading to representation of arbitrary input combinations in at least 10 target neurons in a 100,000 population. In the presence of larger ensembles, spatiotemporally ordered convergence of three to five axons from temporally ordered ensembles is also likely. These active clusters result in higher neuronal activation in the presence of strong dendritic nonlinearities and low background activity. We mathematically and computationally demonstrate a tight interplay between network connectivity, spatiotemporal scales of subcellular electrical and chemical mechanisms, dendritic nonlinearities, and uncorrelated background activity. We suggest that dendritic clustered and sequence computation is pervasive, but its expression as somatic selectivity requires confluence of physiology, background activity, and connectomics.
GATA6 regulates WNT and BMP programs to pattern precardiac mesoderm during the earliest stages of human cardiogenesis
Authors: Bisson Joseph A , Gordillo Miriam , Kumar Ritu , de Silva Neranjan , Yang Ellen , Banks Kelly M , Shi Zhong-Dong , Lee Kihyun , Yang Dapeng , Chung Wendy K , Huangfu Danwei , Evans Todd
Published: October 2024

Haploinsufficiency for
GATA6
is associated with congenital heart disease (CHD) with variable comorbidity of pancreatic or diaphragm defects, although the etiology of disease is not well understood. Here, we used cardiac directed differentiation from human embryonic stem cells (hESCs) as a platform to study GATA6 function during early cardiogenesis. GATA6 loss-of-function hESCs had a profound impairment in cardiac progenitor cell (CPC) specification and cardiomyocyte (CM) generation due to early defects during the mesendoderm and lateral mesoderm patterning stages. Profiling by RNA-seq and CUT&RUN identified genes of the WNT and BMP programs regulated by GATA6 during early mesoderm patterning. Furthermore, interactome analysis detected GATA6 binding with developmental transcription factors and chromatin remodelers suggesting cooperative regulation of cardiac lineage gene accessibility. We show that modulating WNT and BMP inputs during the first 48 hours of cardiac differentiation is sufficient to partially rescue CPC and CM defects in
GATA6
heterozygous and homozygous mutant hESCs. This study provides evidence of the regulatory functions for GATA6 directing human precardiac mesoderm patterning during the earliest stages of cardiogenesis to further our understanding of haploinsufficiency causing CHD and the co-occurrence of cardiac and other organ defects caused by human
GATA6
mutations.
FABP4-mediated lipid accumulation and lipolysis in tumor associated macrophages promote breast cancer metastasis
Authors: Yorek Matthew , Jiang Xingshan , Liu Shanshan , Hao Jiaqing , Yu Jianyu , Avellino Anthony , Liu Zhanxu , Curry Melissa , Keen Henry , Shao Jianqiang , Kanagasabapathy Anand , Kong Maiying , Xiong Yiqin , Sauter Edward R , Sugg Sonia L , Li Bing
Published: October 2024

A high density of tumor-associated macrophages (TAMs) is associated with poorer prognosis and survival in breast cancer patients. Recent studies have shown that lipid accumulation in TAMs can promote tumor growth and metastasis in various models. However, the specific molecular mechanisms that drive lipid accumulation and tumor progression in TAMs remain largely unknown. Herein, we demonstrated that unsaturated fatty acids (FAs), unlike saturated ones, are more likely to form lipid droplets in macrophages. Specifically, unsaturated FAs, including linoleic acids (LA), activate the FABP4/CEBPα pathway, leading to triglyceride synthesis and lipid droplet formation. Furthermore, FABP4 enhances lipolysis and FA utilization by breast cancer cells, which promotes cancer cell migration
in vitro
and metastasis
in vivo
. Notably, a deficiency of FABP4 in macrophages significantly reduces LA-induced lipid metabolism. Therefore, our findings suggest FABP4 as a crucial lipid messenger that facilitates unsaturated FA-mediated lipid accumulation and lipolysis in TAMs, thus contributing to the metastasis of breast cancer.
PA28γ promotes the malignant progression of tumor by elevating mitochondrial function via C1QBP
Authors: Wang Jiongke , Shi Yujie , Wang Ying , Shen Yingqiang , Liu Huan , Sun Silu , Wang Yimei , Zhou Xikun , Zhou Yu , Zeng Xin , Li Jing , Chen Qianming
Published: October 2024

Proteasome activator 28γ (PA28γ) plays a critical role in malignant progression of various tumors, however, its role and regulation are not well understood. Here, using oral squamous cell carcinoma (OSCC) as main research model, we discovered that PA28γ interacted with complement 1q binding protein (C1QBP), which is dependent on the N-terminus of C1QBP rather than the known functional domain (amino acids 168-213). Notably, we found that PA28γ can enhance C1QBP protein stability in OSCC. Functionally, PA28γ contributes to the malignant progression of OSCC by affecting mitochondrial morphology and oxidative phosphorylation (OXPHOS) through C1QBP in vitro and vivo. Mechanically, PA28γ upregulate the expression of optic atrophy 1 (OPA1), mitofusin 2 (MFN1), mitofusin 2 (MFN2) and the mitochondrial respiratory complex by C1QBP. Moreover, in a clinical cohort of OSCC patients, PA28γ was positively correlated with C1QBP expression and negatively correlated with prognosis. Therefore, C1QBP is also a potential target for the treatment and prognosis of cancer.
The triad interaction of ULK1, ATG13, and FIP200 is required for ULK complex formation and autophagy
Authors: Hama Yutaro , Fujioka Yuko , Yamamoto Hayashi , Mizushima Noboru , Noda Nobuo N
Published: October 2024

In mammals, autophagosome formation, a central event in autophagy, is initiated by the ULK complex comprising ULK1/2, FIP200, ATG13, and ATG101. However, the structural basis and mechanism of the ULK complex formation remain poorly understood. Here, we predicted the core interactions organizing the ULK complex using AlphaFold, which proposed that the intrinsically disordered region of ATG13 binds to the base of the two UBL domains in the FIP200 dimer using two phenylalanines and to the tandem MIT domain of ULK1, allowing for the 1:1:2 stoichiometry of the ULK1–ATG13–FIP200 complex. We confirmed the predicted interactions by point mutations and revealed the existence of direct triad interactions among ULK1, ATG13, and FIP200 in vitro and in cells, in which each interaction was additively important for autophagic flux. These results indicate that the ULK1–ATG13–FIP200 triadic interaction is crucial for autophagosome formation and provide a structural basis and insights into the regulation mechanism of autophagy initiation in mammals.
Knowledge, attitude, and practice toward hyperuricemia among healthcare workers in Shandong, China
Authors: Peng Honghai , Zhang Ke , Zhang Chunxue , Gao Jun
Published: October 2024

Background

Hyperuricemia is a relatively common condition, with a prevalence of over 20% among the general population. Also, most patients initially present no symptoms. This study aimed to investigate the knowledge, attitude, and practice (KAP) toward hyperuricemia among healthcare workers in Shandong, China.

Methods

Healthcare workers were recruited in this cross-sectional study conducted in Shandong in December 2022. A self-designed questionnaire was used to collect demographic information and KAP data.

Results

A total of 372 questionnaires were distributed, and 216 (58.06%) valid questionnaires were collected from 131 physicians, 80 nurses, and five other healthcare workers. The participants had a mean score of 10.76 ± 2.53 (possible range: 0–14, 76.9%) and 31.94 ± 2.58 (possible range: 0–40, 79.9%) in knowledge and attitude, respectively. The physicians’ and nurses’ practice scores were 47.57 ± 5.34 (possible range: 0–55, 86.5%) and 30.06 ± 4.11 (possible range: 0–35, 85.9%), respectively. The attitude scores were independently associated with proactive practice in both physicians (P < 0.001) and nurses (P = 0.046).

Conclusion

This study found that healthcare workers in Shandong had adequate knowledge, positive attitudes, and proactive practices towards hyperuricemia. However, there is room for improvement in the attitudes of both physicians and nurses to achieve better practice.
Changes of collagen content in lung tissues of plateau yak and its mechanism of adaptation to hypoxia
Authors: Li Jingyi , Huang Nating , Zhang Xun , Sun Ci , Chen Jiarui , Wei Qing
Published: October 2024

Collagen is crucial for tissue structure, functional maintenance, and cellular processes such as proliferation and differentiation. However, the specific changes in collagen expression and its associated genes in the lung tissues of yaks at high altitudes and their relationship with environmental adaptation remain poorly understood. Studying differences in the content of collagen fibers and gene expression between yaks at high (4,500 m) and low (2,600 m) altitudes, as well as between cattle at low altitudes (2,600 m). Using Masson staining, we found that the collagen fiber content in the lung tissues of yaks at low altitude was significantly higher compared to yaks at high altitude and cattle at the same altitude (P < 0.05). It was revealed through transcriptomic analyses that genes differentially expressed between high and low altitude yaks, as well as between low altitude yaks and cattle, were notably enriched in pathways related to cell adhesion, collagen synthesis, focal adhesion, and ECM-receptor interactions. Specifically, genes involved in mesenchymal collagen synthesis (e.g., COL1A1, COL1A2, COL3A1), basement membrane collagen synthesis (e.g., COL4A1, COL4A2, COL4A4, COL4A6), and peripheral collagen synthesis (e.g., COL5A1, COL6A1, COL6A2, COL6A3) were significantly upregulated in the lung tissues of yaks at low altitude compared to their high altitude counterparts and cattle (P < 0.05). In conclusion, yaks at lower altitudes exhibit increased collagen synthesis by upregulating collagen gene expression, which contributes to maintaining alveolar stability and septal flexibility. Conversely, the expression of collagen genes in yak lung tissues was down-regulated with the increase in altitude, and it was speculated that the decrease in collagen may be used to constrain the function of elastic fibers that are more abundant at high altitude, so as to enable them to adapt to the harsh environment with hypoxia and high altitude. This adaptation mechanism highlights the role of collagen in environmental acclimatization and contributes to our understanding of how altitude and species influence collagen-related physiological processes in yaks.
Design Stories in the Global South: Fabulation as a Means to Decolonize Design History
Authors: Meliande Clara
Published: October 2024

This article aims to discuss, through the critical fabulation of Saidiya Hartman, the use of fabulation in the field of design history as a decolonizing methodological tool, as it challenges and problematizes notions of truth and neutrality in research and the boundaries of scientific writing. Assuming that all writing, even that which claims to be committed to reality, has elements of fiction, I argue that researchers in design can engage in writing that, with historical rigor, utilizes imagination not as a means of falsification but as a materialization of what is suggested in documents but escapes the possibility of verification. I conclude that fabulation can be employed as a means to imagine alternative occurrences, as a way to speculate on what cannot be answered through archival materials, and as a tactic for democratizing academic discourse.
Biological Suppression of Sclerotium rolfsii in Groundnut Cultivation: A Path Towards Sustainable Disease Management
Authors: Lavanya.K  , Vidyasagar.B  , Ameer Basha.S  , Triveni S.
Published: October 2024

Stem rot of groundnut caused by Sclerotium rolfsii Sacc, is a major soil borne disease which impact on groundnut cultivation both in India and globally. The primary objective of this study was to assess the antagonistic potential of biocontrol agents against the pathogen, both individually and in combination, under In vitro and glasshouse conditions. The results of the present investigation indicated that the application of microbial consortia was more effective against Sclerotium rolfsii than individual bioagents. Specifically, seed treatment with microbial consortia MC1, MC2, MC3, and MC4 resulted in lower disease incidence with 13.80%, 16.01%, 20.0%, and 22.60% respectively, compared to the pathogen check, which had a 74.12% PDI. Additionally, these treatments also enhanced plant growth through improved plant growth-promoting traits under glasshouse conditions.
Identification of Concrete Crack Using Deep Learning Based Approach
Authors: Bian Ziyan
Published: October 2024

Cracks reflect the safety and durability of concrete structures, and the existing artificial crack detection has the disadvantages of low efficiency and large error. However, the use of deep learning of images to identify cracks has the advantages of high efficiency, small error and low cost. This paper systematically discusses the deep learning in the identification of concrete structure cracks, expounds the deep learning technology, studies the SqueezeNet network model and YOLO (You Only Look Once) network model in the field of concrete structure crack identification, and improves the model according to the test results. In this paper, the classification accuracy based on crack trend is improved by increasing the width and depth of the Fire module of the SqueezeNet network. Secondly, the target detection accuracy is improved by the transfer learning of the YOLO model. The results show that the classification accuracy of the improved SqueezeNet model is more than 82% and the recognition accuracy of YOLO model is more than 92%.