bluuebunny/crossref_metadata_2025 huggingface dataset:
WELSH TOPONYMS AS REFLECTION OF LINGUISTIC AND ETHNOCULTURAL LEGACY OF THE CELTS WITHIN THE TERRITORY OF WALES
Authors:   KSPU named after V.P. Astafiev, ISAEVA T.B. , PASHIN V.M. ,   KSPU named after V.P. Astafiev
Published: January 2021

Statement of the problem. The Celtic languages are formed as one of the primary groups within the Indo-European language family. The 6th – 7th centuries saw the exodus of the Celts, as well as the Celtic language by the Germanic tribes and their languages from the territory of Britain pushed. Along with that we had our special interest riveted on linguistic artifacts which support the assumption about some Celtic tribes to staying within certain territories, particularly, within the territory of Wales, where during historical conquests, a considerable number of the Celtic tribes were pushed back to avoid the fate of being enslaved by the Anglo-Saxons. The object of linguistic analysis was the contemporary toponyms of Wales, including the linguistic and ethnic-cultural legacy of the Celts within the diachrony. The purpose of the article is to reveal and show the Celtic substrate in contemporary Welsh oikonymy within the territory of Wales as a proof of the preservation of the ancient lingo-social legacy of the Celts. The research methodology includes method of searching for particular toponymical units, which include the Celtic substrate, inductive method in finding a great number of oikonyms for creation of categorical classification according to the meaning of the name, comparative historical method, and the method of etymological analysis. Research results. The preservation of ancient ethnic-cultural legacy of the Celts and its distinctive interpretation are needed for understanding the movement of the English language expansion on a certain territory during the ancient period and immersion into the lingo-cultural, lingo-cognitive image of the world reflected in oikonyms. As a result of exploring the Celtic toponymic layer, it was found out that the north-western part of Wales was less influenced by the Anglo-Saxon invaders in diachrony and the local population of Celtic origin were able to preserve their unique ethnic-cultural identity. The conclusion. All names of places in Wales, especially the ones that are located in the north-western part remain unchanged from ancient times. Despite the attempts to push out the Celtic language and pressure on the part of the Anglo-Saxon invaders the expansion of the English language was halted by the courageous actions of the ancestors of the contemporary Welsh people. Today, this is reflected in the prevailing Celtic substrate among genuine Wales’ toponyms.
APPLICATION OF BREATHHOLD IN SPORTS TRAINING OF 10–12 YEAR OLD CHILDREN AS A WAY TO INCREASE THEIR FUNCTIONAL ENDURANCE
Authors:   Angara Sports School of Olympics, RZHANOV A.A.
Published: January 2021

Statement of the problem. The article describes an alternative and affordable method of hypoxic training through holding the breath on inhalation and exhalation, as a tool for developing endurance. The relevance of the topic is in the absence of a method that develops endurance and hypoxic characteristics with a sparing effect on heart rate (HR) and availability in use. Research methodology (materials and methods). Using hypoxic tests of Stange and Genchi (holding the breath on the inhale and exhale by the stopwatch), as markers that determine the development of endurance, we arranged the experiment. We divided 24 young men of volleyball players aged 10–12 into two groups, experimental and control, 12 people in each group with a uniform level of sports fitness. The arithmetic mean of indices in the introductory Stange samples in the control group and in the Genchi samples showed 1 minute 8 seconds and 31 seconds, respectively. In the experimental group, there were 48 seconds in the Barbell samples and 25 seconds in the Genchi samples, confirming the uniformity of training in the development of endurance. The experiment lasted three months, during which time the experimental group underwent breathing exercises on inhalation and exhalation, regulated by the time of 20 and 7 seconds, maximum in the corridor of execution, and the control group trained in the normal mode. At the end of the experiment, samples were taken, similar to the introductory ones. The average result of the breath holding time in the control group changed by 4 seconds in the Genchi and Stange samples, in relation to their own results, and the results of the experimental group in relation to their own results increased by 1 minute 13 seconds in the Stange sample and by 23 seconds in the Genchi sample. The values of the samples are detailed in Table. Research results. As a result of the study, the experimental group exceeded the control group in the samples with breath-holding during inhalation (Stange) by 47 seconds and breath-holding during exhalation (Genchi) by 31 seconds. This practically confirms the significance of hypoxic training with regulated breath holding to develop endurance. Conclusion. The experiment proves the effectiveness of alternative hypoxic training with regulated breath holding during inhalation and exhalation and contributes to the further study of the tool, which is available for material and technical use.
THE PROFITABILITY, FIRM’S SIZE, DIVIDEND PAYOUT RATIO AND FIRM’S VALUE: CAPITAL STRUCTURE INTERVENTION
Authors: Rahmawati Christina Heti Tri
Published: January 2021

This research aims to investigate the influence of profitability, firm’s size, and dividend payout ratio towards firm’s value with the capital structure as the intervening variable. The samples employed were the manufacturing companies registered in Indonesia Stock Exchange from 2016-2018. The statistic method used to investigate the hypothesis was a path analysis. The result of the hypothesis investigation proved that the profitability brought significant negative influence towards capital structure, the firm’s size and dividend payout ratio brought insignificant influence towards capital structure; the profitability, firm’s size, dividend payout ratio, and capital structure brought significant positive influence towards the firm’s value. On the other hand, the intervening testing results proved that the capital structure intervened in the influence of the profitability towards the firm’s value, and the capital structure did not intervened in the influence of the firm’s size and dividend payout ratio towards the firm’s value. Being able to pick stocks with profitability value and high dividend payout ratio and choosing a large-scale company are the research implications for investors to scale up the firm’s value. Furthermore, companies can increase profitability, pay higher dividend, and choose a large-scale company by balancing the capital structure, so that firm’s value increases.
KORELASI DINAMIS ANTARA PERGERAKAN HARGA MINYAK DUNIA DAN INDEKS HARGA SAHAM SEKTORAL DI BURSA EFEK INDONESIA
Authors: Safitri Yunita Dewi , Robiyanto Robiyanto
Published: January 2021

Changes in the situation that move very quickly on the commodity market have an impact on financial markets, one of which is the stock market in Indonesia. Therefore this study aims to examine the dynamic correlation between the movement of world oil prices and the Sectoral Stock Price Index listed on the Indonesia Stock Exchange (IDX). The data used is obtained from secondary data in the form of daily closing price data for world oil prices and Sectoral Stock Price Index from January 2017 to June 2020. The analysis technique used is Dynamic Conditional Correlation-Generalized Autoregressive Conditional Heteroscedasticity (DCC-GARCH), due to previous studies mostly using a static approach. The results of this study show that the DCC-GARCH value between world oil prices (Brent and WTI) and Sectoral Stock Price Index tends to be very weak. A negative dynamic correlation was also found in the Consumer Goods Sector. This research can be a reference for investors who want to invest stocks in Indonesia by looking at the correlation between world oil prices and the Sectoral Stock Price Index.
به‌ریه‌ككه‌وتنی شێوه‌زاره‌كانی زاری كرمانجیی ناوه‌ڕاست له‌شاری كۆیه‌دا‌
Authors: Hamad Dindar Issa , سابیر شادان
Published: January 2021

ئةم تويَذينةوةية بة ناونيشاني (بةريةككةوتني شيَوةزارةكاني زاري كرمانجيي ناوةرِاست لة شاري كؤيةدا)ية، هؤكاري هةلَبذاردني ئةم تويَذينةوةية بؤ ئةوة دةطةرِيَتةوة، كة ئةم ناونيشان و بابةتة كاريَكي تازةية و كاري كةم لةسةر كراوة، ئيَمة دةمانةويَت لةم تويَذينةوةيةدا ئةم دياردة زمانيية رِونبكةينةوة، واتة ئامانجمان لةم تويَذينةوةية ئةوةية، ئةو بةريةككةوتنانة بخةينةرِوو، كة لة نيَوان شيَوةزاري كؤية و شيَوةزارةكاني تري كرمانجيي ناوةرِاست رِودةدات، ضونكة بةهؤي هةلَكةوتي جوطرافياي شاري كؤيةوة بة رِوني ئةم دياردة زمانيية لةشاري كؤية هةستي ثيَدةكريَت‌، رِيَبازي تويَذينةوةكةشمان‌، رِيَبازيَكي وةسفي شيكاريية، كةرةستةي تويَذينةوةكة بريتيية لة وشة و دةستةواذة و رِستةي ئاخيَوةراني ناوضةي تويَذينةوة، ناوةرِؤكي تويَذينةوةكة لة ثيَشةكييةك و سيَ بةش ثيَكهاتووه لة بةشي يةكةمدا باسمان لة زمان و زار، ضةمك و ثيَناسةي شيَوةزار، زارةكاني زماني كوردي، ضةمك و ثيَناسة و جؤرةكاني بةريةككةوتن كردووة، بةشي دووةميشمان تايبةت كردووة بةوةي كةوا بؤضي شاري كؤية وةك نمونة وةرطيراوة، هةروةها ئةو هؤكارانةشمان رِونكردؤتةوة كة بونةتة هؤي بةريةككةوتني شيَوةزارةكان لة ناوضةي تويَذينةوة، لة بةشي سيَيةمدا بةشيَوازي ثرِاكتيكي نمونةمان هيَناوةتةوة و بةريةككةوتني شيَوةزارةكانمان لة ضوارضيَوةي نمونةكاندا خستؤتةرِو، لة ئاستةكاني دةنطسازي و مؤرفؤلؤجي و فةرهةنط و رِستةسازي دا، لة كؤتاييشدا ئةنجام و ليستي سةرضاوةكان خراوةتةرِو.
الصراع والتعاون في العلاقات الدولية: الإسهامات النظرية للنقاش بين الواقعية الجديدة وبين الليبرالية الجديدة
Authors: علي عمران
Published: January 2021

يتناول هذا البحث النقاش[1] بين الواقعية الجديدة وبين الليبرالية الجديدة في إطار حقل العلاقات الدولية ويسلط الضوء على أهم طروحات النظريتين، وخاصة فيما يتعلق بوجهات نظرهما حول هيكل العلاقات الدولية وهل يحكمه الفوضى والصراع أم التعاون. كانت، ولا زالت، دراسة الصراع والتعاون في العلاقات الدولية من المهام الرئيسية للبحث والتحليل بالنسبة لمنظري وباحثي العلاقات الدولية، وأصبح هذا الترابط بين الصراع والتعاون القضية الرئيسية في النقاش بين النظريتين السائدتين في العلاقات الدولية.  تعتبر تظريتي الواقعية الجديدة والليبرالية الجديدة من أكثر النظريات تأثيرا على العلاقات الدولية، ويعتبر النقاش بين النظريتين من أكبر واهم النقاشات في حقل العلاقات الدولية. يسعى هذا البحث إلى بيان وشرح الاسهامات النظرية لكل من النظريتين فيما يتعلق بالصراع والتعاون في العلاقات الدولية، ومدى مساهمة طروحات الليبرالية الجديدة، خاصة فيما يتعلق بدور المؤسسات الدولية في زيادة التعاون الدولي، وفي التقليل من هيمنة الرؤية الواقعية في العلاقات الدولية وخاصة فيما يتعلق بسيادة الفوضى والصراع من أجل القوة. تناقش هذه الدراسة أن النقاش بين الواقعية الجديدة وبين الليبرالية الجديدة لم يساهم بشكل كبير في تطوير نظرية العلاقات الدولية، حيث لم يساهم هذا النقاش بشكل كبير في التقليل من هيمنة سياسات القوة في العلاقات الدولية وحل المشاكل الدولية الناتجة عنها.

[1] المقصود ب (النقاش) هنا هو النقاش النظري بين الواقعية الجديدة وبين الليبرالية الجديدة. وهو أحد  (النقاشات الكبرى) أو (الحوارات العظمى)، حسب استخدام الباحثين، في العلاقات الدولية والمؤخوذة من الاصل الانكليزي (Great debates)، والتي تركز على النقاشات النظرية في تطور حقل العلاقات الدولية منذ بداية القرن العشرين. وهي تشمل، في الغالب، ثلاثة نقاشات كبرى: النقاش بين الواقعية وبين المثالية-الليبرالية، والنقاش بين الواقعية وبين السلوكية، والنقاش بين الواقعية الجديدة وبين الليبرالية الجديدة. وهناك من يضيف نقاشا رابعا مهما وهو النقاش بين الوضعية وما بعد الوضعية (انظر مثلا، تيم دان وآخرون، ترجمة ديما الخضرا، 2016؛Lake, 2013; Lapid, 1989 ).
تاثير استراتيجية النمذجة في التفكير الاستدلالي و اكتساب فن اداء بعض المهارات الهجومية في كرة اليد
Authors: امبارك محمد
Published: January 2021

هدف البحث الكشف عن أثر استراتيجية النمذجة على التفكير الاستدلالي و اكتساب فن اداء المهارات الهجومية في كرة اليد ، واستخدم الباحث المنهج التجريبي باستخدام التصميم  ذو المجموعتين التجريبية والضابطة ذات الاختبار القبلي والبعدي) لملاءمته أهداف البحث ومشكلته، تكون مجتمع البحث من طلبة المرحلة الثانية في قسم التربية الرياضية / فاكولتي التربية/ جامعة زاخو للعام الدراسي 2019-2020 و البالغ عددهم (52) طالباً ، أما أدوات جمع بيانات البحث فقد اشتملت على مقياس التفكير الاستدلالي (المفتي، 1997) الذي قام الباحث بتقنينه على البيئة المحلية وإيجاد الأسس العلمية له. بالإضافة إلى تقييم فن اداء بعض المهارات الهجومية في لعبة كرة اليد. واستخدم الباحث الحقيبة الإحصائية SPSS لمعالجة البيانات وتوصل الباحث إلى الاستنتاجات التالية)  اسهمت استراتيجية النمذجة و الاسلوب المتبع في تنمية التفكير الاستدلالي و رفع مستوى فن اداء المهارات الهجومية في لعبة كرة اليد لدى طلاب المجموعة التجريبية و الضابطة ،  تفوقت المجموعة التجريبية التي استخدمت استراتيجية النمذجة بنتائج ايجابية في تنمية التفكير الاستدلالي و رفع مستوى فن اداء المهارات الهجومية في لعبة كرة اليد على المجموعة الضابطة).
بناء مقياس المركزية واللامركزية في صنع قرارات الاتحاد العراقي المركزي لكرة السلة
Authors: محمد صفد , عزيز خالد
Published: January 2021

الهدف من البحث:

بناء مقياس المركزية واللامركزية في صنع قرارات الاتحاد العراقي المركزي لكرة السلة.

التعرف على ترتيب عوامل مركزية ولامركزية صنع القرارات في الاتحاد العراقي المركزي لكرة السلة من وجهة نظر العاملين في الاتحادات الرياضية الفرعية.

    اُستخدم المنهج الوصفي بطريقة المسح لملاءمته ولطبيعة البحث، وتألفت العينة من قسمين، القسم الأول شمل عينة البناء التي بلغ عددها (108) أفراد عاملون في الاتحادات الرياضية الفرعية لكرة السلة في العراق، في حين شمل القسم الثاني عينة التطبيق التي بلغ عددها (40) فرداً عاملاً في الاتحادات الرياضية الفرعية لكرة السلة في العراق.

من وسائل جمع البيانات:

أداة لقياس المركزية واللامركزية في صنع القرارات:

     قام الباحثان ببناء مقياس المركزية واللامركزية في صنع القرارات لدى الاتحاد العراقي لكرة السلة بعد أن توافرت الشروط العلمية للمقياس، وقد تضمن المقياس (20) فقرة.

عُولجت البيانات إحصائياً باستخدام:

     الوسط الحسابي والانحراف المعياري وقانون النسبة المئوية والمتوسط الفرضي ومعامل ألفا ومعادلة جتمان، واُستخدمت معادلة سبيرمان براون.

أهم الاستنتاجات هي:

صلاحية مقياس المركزية واللامركزية في صنع القرارات في قياس طبيعة صنع قرارات الاتحاد العراقي لكرة السلة.

أسلوب صنع قرارات الاتحاد العراقي لكرة السلة هو الأسلوب اللامركزي من وجهة نظر العاملين في الاتحادات الرياضية الفرعية.

وفي ضوء النتائج قدم الباحثان عدداً من التوصيات من أهمها:

تطبيق مقياس المركزية واللامركزية في صنع القرارات بعد تكييفه بطريقة علمية على اتحادات أخرى في أنحاء العراق كافة.

ضرورة استمرارية الاتحاد العراقي لكرة السلة في دعم التوجه نحو اللامركزية في صنع القرارات، وذلك بمنح العاملين في الاتحادات الرياضية الفرعية المزيد من الصلاحيات الضرورية للقيام بواجباتهم بمرونة وفاعلية، وطرح القضايا المطلوب اتخاذ قرار بشأنها ومناقشتها مع العاملين الذين يقع على عاتقهم تنفيذ القرار.

على القيادات الإدارية في الاتحاد العراقي المركزي لكرة السلة أن تقوم بالإجراء المناسب الذي يضمن المشاركة الأوسع للعاملين في الاتحادات الرياضية الفرعية في عملية صنع القرارات بشكل فعال وذلك من خلال زيادة عقد الاجتماعات وفتح قنوات الاتصال كافة معهم والقيام بزيارات ميدانية إلى المحافظات.

وقدم الباحثان المقترحين الآتيين:

إجراء دراسة مقارنة في مركزية ولامركزية صنع قرارات الاتحاد العراقي لكرة السلة مع اتحادات أُخر.

2. العمل على إصدار قانون لتفرغ العاملين في الاتحادات الرياضية للقيام بمهامهم في الاتحادات مع الاحتفاظ بحقوقهم الرسمية في المؤسسات التي يعملون بها، وذلك من أجل أن تتاح لهم فرصة الإبداع، وتقديم الخدمات في كلتا الوظيفتين.
A case report on bell’s palsy induced after uprooting mandibular lower molar
Authors: Lakshmi Narasimha G  , Reddy Santhosh C  , Gnaneswari R V  , Sunaina V  , Kalpana P  , Nissi Christina D
Published: January 2021

Bell’s Palsy or Facial Nerve Paralysis is an unusual form of neuropathy after maxillofacial surgery. Its incidence is about 23 per 100000 persons annually, and very few cases were reported in the literature. Dr Charles Bell discovered it in 1821 as complete facial paralysis. Various aetiologies associated with the bell’s palsy include trauma, pregnancy, diabetes, and neoplastic infiltrations. Apart from these recent kinds of literature report, surgical interventions like dental extractions are also a significant cause of this condition. With this, we report a case of 25 years old male presented to Government General Hospital with symptoms of drooping of eyebrow and incomplete eye closure with ringing sensation in the left ear. On investigation of his past medical history, he underwent tooth extraction before a month. Therefore, the condition was diagnosed as bell's palsy induced after the dental extraction. He was treated with prednisolone, acyclovir, and Betahistine for ten days. After the treatment, there is an improvement in the facial movements, and symptoms were normalized. Bell's palsy is common, but this condition after dental extractions is very rare. Hence this case signifies the rare occurrence of neuropathies after dental extractions and the need for early treatment procedures must be initiated to reduce the future neurological complications in post-dental operative patients.
Formulation and Evaluation of Brimonidine Maleate Nanolipid in Situ Gel
Authors: Mohd Azharuddin  , Theivendren Panner Selvam  , Maya Sharma  , Jayesh Dwivedi
Published: January 2021

The main objective of present research work was aimed to formulate and evaluate the nano lipid-based drug delivery system by incorporating a brimonidine maleate drug for ocular therapy. The patient can be improved by preparing nano lipid in situ gel as a vehicle by reducing the frequency of administration and increasing the ocular bioavailability.  Nanolipids were prepared by film hydration technique and then prepared nanolipids were incorporated into insitu gel by using various polymers like Carbopol 940 and HPMC K15M with different concentration. The various formulations prepared showed excellent and effective results for visual appearance, pH, and gellation study. It was further observed that formulations had  entrapment efficiency within the range of 67.20% to 97.3% for brimonidine maleate loaded insitu gel formulations. F1 entrapment efficiency was found to be 97.3% and shown maximum when compared with other formulations. From the drug release data, it was found that F1 (99.0%) shows maximum drug release compare to other formulations.
A Study on Hypertension among Persons Living with HIV attending ART Centers in TamilNadu- A Descriptive Cross-Sectional Study
Authors: Krishna Prasanth B  , Mahalakshmi K  , Kalpana S  , Anantha Eashwar V M
Published: January 2021

People suffering from immunosuppressive conditions like Human Immunodeficiency Virus (HIV) are more prone to suffer from non-communicable diseases like hypertension, which is not identified and treated at an earlier stage, can lead to significant mortality and morbidity in them. The study design was a cross-sectional study done in select Anti-Retroviral Therapy (ART) centers in Government hospitals in Tamil Nadu during a period from 2017-2018. Data regarding their HIV status, treatment history and Body Mass Index (BMI) were recorded and Blood Pressure (BP) was recorded by using mercury sphygmomanometer using standard guidelines. Data was entered in Microsoft excel and analyzed by using SPSS version 22 software. The study population comprised of 75% males and 25% females. Mean age of study participants was 45+8.2 years and the mean BMI was 22+3.4. The prevalence of hypertension among HIV affected individuals was found to be 14.63%. According to JNC criteria, 34% were having Stage 1 hypertension and 33% had Stage 2 hypertension and only 23% were on treatment. Significant association was found between increasing age, gender, BMI and hypertension. Health education and awareness creation has to be created among HIV patients on maintaining a healthy diet and lifestyle so that, obesity can be prevented or reduced which could play an important role in NCD’s like hypertension and also hypertensive patients have to be identified and treated at early stage to reduce the morbidity and mortality.
Regulatory compliances in development of commercial scale process of Nanoparticles (Liposomes and Niosomes) in pharmaceutical industry : A review
Authors: Daka Nagarjuna Reddy  , Mahaveer Singh  , Birendra Shrivastava  , Ravi Kumar Konda
Published: January 2021

The main objective of this review work was designed to explore the regulatory environments that govern the pharmaceutical industry. Main objective of regulatory department is to maintain the quality, safety and efficacy of the medical products it also ensures the standard of medicinal product for sales, importing and manufacturing. The biggest challenge faced by the pharma manufactures is Scaling up their production. Our review process focuses on regulatory requirements concerning Liposomes and Niosomes and their limitations in respect to industrial applicability. In detail explanation of what type of information should be submitted to FDA and EU in new drug applications (NDAs) or abbreviated new drug applications (ANDAs). By comparing these two developed regulatory markets we can build a strong regulation in Indian market on Liposomes and Niosomes. The review study deals with the sound knowledge about regulatory landscape that governs the pharmaceutical industry. Study describes in depth about liposomes and niosomes delivery systems and gives a critical overview of the current regulatory landscape surrounding commercialization efforts of higher-level complexity systems, the expected requirements and the hurdles faced by companies seeking to bring novel liposome and noisome based systems for clinical use to market.
Adipogenic differentiation potential of porcine bone marrow mesenchymal stem cells grown in different basal media formulations
Authors: Sangeetha Kannan  , Jyotirmoy Ghosh  , Sujoy K. Dhara
Published: January 2021

Bone marrow-derived porcine mesenchymal stem cells (pMSC) are precursors of multiple lineage cells. However, the differentiation potential of pMSC might vary due to the culture media in which they are isolated and grown. In this study the effects of αMEM, aDMEM, M199, αMEM/M199, aDMEM/M199 and αMEM/aDMEM was determined on pMSC expression of adipogenic marker genes PPARγ, C/EBPα and ApN at passage 5 and 10; and differentiation potential of pMSC at passage 5. Relative expressions of the genes were determined by qPCR assay. Adipogenic differentiation progress was determined by microscopic evaluation and accumulation of lipid vesicles in cells after day 21 differentiation was confirmed by Oil Red-O staining. Results indicated varying expressions of adipogenic marker genes at passage 5 and 10 in pMSC grown in different culture media. Adipogenic differentiation characteristics also varied in different culture media, grown cells depending on the expression of adipogenic marker genes. Classification in order of differentiation potential revealed that the pMSC grown in M199 and αMEM/M199 was the best, followed by aDMEM/M199 and αMEM/aDMEM the intermediate and αMEM and aDMEM the least suitable media. Effect of media interaction analysis indicated that M199 media might have played a significant role in up-keeping of the desired marker gene expression and adipogenic differentiation potential of the pMSC. In conclusion, adipogenic differentiation potential of pMSC varied due to the differences in basal media composition and the M199 played a significant role in skewing pMSC towards adipogenic lineage.
Variation of Serum Interleukin, Gonadotropins hormone and Steroid hormone levels in women with Ovarian Cancer
Authors: Lana Muhammad Ali  , Parween Abdulsamad Ismail
Published: January 2021

Ovarian cancer has high mortality and delayed diagnosis. Inflammation is considered as a risk for ovarian carcinoma, and it contributes to all grades of tumour progression. Inflammation involved in the development of cancer cell and can be caused by an increase in the formation of pro-inflammatory cytokines. This research was conducted to assess serum Interleukin, Gonadotropins hormone and Steroid hormone levels in ovarian cancer patients and to assess their impact in disease action. The present study is composed of 85 women (mean age = 62.03±12.4 yrs) with clinically and pathologically confirmed ovarian cancer and 65 healthy women as a control group (mean age = 61±12.1 yrs). The measured biochemical parameters included: the level of serum gonadotropins(LH, luteinizing hormone; FSH, follicle-stimulating hormone), steroid hormones (estrogen, progesterone, prolactin, testosterone) and Interleukin (IL-4, IL-6, and IL-8). The results demonstrated significantly high values of steroid hormones (p<0.01, p<0.01, p<0.05,p<0.002, p<0.01 (estrogen, progesterone, prolactin, testosterone) and significantly high ( p<0.001, p<0.002, p<0.01)values in (IL-4, IL-6, and IL-8) in ovarian cancer in comparison with control group. There were also significantly high (p<0.0001, p<0.05 values of sera LH and FSH in women ovarian cancer in comparison with the control group. p<0.01, p<0.001) respectively in ovarian cancer in comparison with the control group. An elevation of serum steroid hormone, gonadotropins, and Interleukin levels in cases of ovarian carcinoma in our study is important as a marker of the disease.
A study on epidemiology, etiology, risk factor and treatment management in chronic kidney disease on children, adult and geriatric patients in a tertiary care teaching hospital: A systematic mini-review
Authors: Naveena B  , Karthikeyan E
Published: January 2021

Chronic kidney disease (CKD) was recognized as universal health problem for population. It can result in a systemic review of epidemiology, etiology, risk factors, and treatment management was reporting the incidence of CKD about children, adult, and geriatric patients by using the research articles from 1982 to 2020. The object of study to find out a incidence about epidemiology, etiology, risk factor, and treatment management for all age groups with CKD patients in review articles. The discussion in this study systemic mini-review was about CKD in children, adult, and geriatric patients. In 2012, 2018 and 2019 epidemiology is mostly geriatrics are effected with CKD compared with children and adults but in 2016 children and geriatrics are equally effected with CKD. In 2017 to 2019 etiology is mostly geriatrics are effected with CKD  when compared with children and adults. From 2000 to 2010 and 2011 to 2020 risk factors are mostly children’s are effected with CKD having risk factors  to compare with adults and geriatrics. The treatment management from 1982 to 2020 the medications are intervented like radioactive iodine,  Azathioprine, methotrexate, lisinopril, hemodialysis,  methotrexate, and lisinopril for all age groups of CKD patients. The study was concluded that patients with CKD has increased the epidemiology, etiology, risk factor, and treatment management on children, adult, and geriatric patients with CKD. Future research should investigate adequate information about children, adults, and geriatric patients with CKD for better outcomes in further study.
Study on the association between serum APO-E levels and serum lipid levels in young smokers
Authors: Dinesh Nath  , Meera Shivasekar  , Vinodhini VM
Published: January 2021

Smoking causes cardiovascular deaths which are about11% of total global death. Cigarette smoking is one of the significant risk factors for cardiovascular disease and atherosclerosis in young age. Apo lipoprotein-E (APO-E) is a glycoprotein which plays an important role in lipid metabolism. However, the relation between serum APO-E levels and serum lipid levels remains controversial. So we aim to find out the association between serum APO-E levels and serum lipid levels in young smokers. The study contains 60 young smokers with CHD aged between 20 to 45 years, and 60 healthy normal individuals were attending in Cardiology OP, Medicine OP and MHC were selected for the study. Serum APO-E levels were measured by Enzyme-linked Immune Sorbent Assay (ELISA), and the lipid profile was measured by the enzymatic method.  The mean serum APO-E levels were significantly (p-value <0.0001) higher in smokers with CHD when compared to the controls. A positive correlation was found between the serum APO-E level and BMI (r-value=0.595), FBG (r-value=0.425), TC (r-value=0.650), TGL (r-value=0.449), LDL (r-value=0.456 ), VLDL (r-value=0.452 ), No of smoking/day (r-value=0.862 ), duration of smoking (r-value=0.726 ) and a negative correlation was found with HDL-C levels. The current study gives a significant correlation between smoking and lipid profile in young smokers. Thus the present study concludes that cigarette smoking produced a significant effect on serum APO-E levels and lipid profile in young smokers which may lead to cardiovascular disease in young smokers.
DAYS OF COVID-19 ARE THE REFLECTION OF DISTRESS AND EMOTIONDAYS OF COVID-19 ARE THE REFLECTION OF DISTRESS AND EMOTION
Authors: Hossain Alamgir
Published: January 2021

There is a time when the corona virus comes when I don't know what the meaning of lockdown is! I do not know what the real form of the epidemic is! It's like a real death procession in the morning,dreaming in your sleep at night.
Pembelajaran Pendidikan Agama Islam bagi Anak Tunalaras di SLB E Prayuwana Yogyakarta
Authors: Wiswanti Cica , Husna Difa Ul
Published: January 2021

Education has a function including making people fear God Almighty and build noble morals. Education is a right for anyone, not least for children with special needs with disabilities, including religious education. Islamic Religious Education is education that instills faith and religious values as well as good moral learning. This study intends to provide a description or description of the implementation of Islamic Religious Education learning for children with Tunalaras at SLB E Prayuwana Yogyakarta. The method we use is descriptive research method with data collection techniques through observation and interviews with a number of related parties. The analysis technique used in this study is a qualitative analysis technique in which the research data will be analyzed in a narrative. As a result, Islamic Religious Education for children with disabilities at SLB E Prayuwana Yogyakarta is carried out like a school in general and what distinguishes it is only in terms of teaching methods. In addition, at SLB E Prayuwana Yogyakarta, students emphasize more on learning Al-Quran. This is done with the hope that children with disabilities there will be able to benefit from reading the Al-Quran.
Analisis Model Pembelajaran Pada Kelas E-Learning
Authors: Ratnaningsih Paskalina Widiastuti , Triayomi Ria
Published: January 2021

Pembelajaran E-learning menjadi platform yang digunakan selama pandemi Covid 19. Pengajar mengawasi yang tepat selama E-learning. E-learning merupakan salah satu bentuk model pembelajaran yang difasilitasi dan didukung pemanfaatan teknologi informasi dan komunikasi. Dosen dan mahasiswa di lingkup universitas juga berfokus pada E-learning. Penelitian ini bertujuan untuk menganalisis penyampaian materi pembelajaran, tugas, metode pembelajaran, dan media yang digunakan dalam pembelajaran E-learning. Penelitian ini menggunakan metode survei. Instrumen pada penelitian ini yaitu kuesioner dan wawancara. Hasil dari kuesioner dan wawancara dapat menyatakan bahwa materi pembelajaran lebih banyak disampaikan dengan Google Meet atau Zoom dan materi disampaikan dengan baik. Responden juga mencari pengetahuan secara mandiri di internet. Pada tugas pembelajaran dapat dipercaya bahwa terdapat banyak tugas pada pembelajaran E-learning, namun tugas yang diberikan memperdalam pengetahuan yang sudah ada. Pada metode pembelajaran E-learning dapat menyatakan bahwa metode yang digunakan lebih banyak dengan ceramah, diskusi, dan tugas. Tersedia pula metode masalah masalah dan menemukan secara mandiri yang digunakan dalam pembelajaran. Pada media pembelajaran E-learning yang digunakan, terdapat beragam media yang digunakan dimana sebagian besar menggunakan sistem manajemen pembelajaran universitas yaitu Lumen dan konferensi virtual seperti Google Meet atau Zoom. Faktor yang mendukung implementasi e-learning adalah mahasiswa maupun dosen sudah cukup melek informasi digital. Media internet yang sedemikian berdaya guna optimal untuk mendukung sistem tersebut.
O PAPEL INDUTOR DA ADMINISTRAÇÃO PÚBLICA CONCERTADA NA EFETIVAÇÃO DOS DIREITOS HUMANOS PELAS EMPRESAS
Authors: Dias Caroline Mendes , De Carvalho Luciani Coimbra
Published: January 2021

Resumo: As diretrizes contemporâneas no âmbito do sistema doméstico que tratam da relação direitos humanos e empresas, incluem o papel de fomento do Estado. Nesse contexto, o problema de pesquisa é analisar qual a responsabilidade do Estado como indutor da proteção dos direitos humanos em atividades empresariais, a partir da concepção da Administração Pública Concertada, com foco na cooperação, para a aplicação das diretrizes voluntárias, previstas no Decreto n. 9.571/2018 e Resolução CNDH n. 5/2020, que partem dos Princípios Orientadores das Nações Unidas, e ODS 8 e 12. Realizou-se pesquisa bibliográfica e documental, método dedutivo, enfoque descritivo e dogmático do Direito.
Celebrities’ Role in the Conflict Resolution Processes: George Clooney in South Sudan
Authors: Ženková Rudincová Kateřina
Published: January 2021

The present article discusses the role of celebrities in the conflict resolution processes presented by the case study of George Clooney’s engagement in South Sudan. Methodologically, it is a critical discourse analysis of published articles in selected media. The main argument of the article is that the role of celebrities in conflict resolution processes is overestimated by media and the image of celebrities’ involvement reproduces stereotyped understanding of distant regions as lacking agency and dependent on the actors from the West. The image of Clooney’s role in the South Sudanese peace process creates an idea that celebrities have been crucial actors in this process. The present article brings critical new insights on the engagement of celebrities, including the fight against the violation of human rights and points out the corruption of South Sudanese politicians.
A atuação resolutiva do Ministério Público Federal na área da saúde pública
Authors: De Paiva Luis Henrique Da Silva , Júnior Djalma
Published: January 2021

Este artigo argumenta que a atuação extrajudicial do Ministério Público Federal na área da tutela coletiva do direito à saúde tem servido para a implementação e o aperfeiçoamento de políticas de saúde pública, tendo a Instituição atuado de forma resolutiva e contribuído para minimização da judicialização dessas questões. O objetivo é explorar as medidas institucionais adotadas pelo Conselho Nacional do Ministério Público e pelo Ministério Público Federal quanto ao fomento da atuação resolutiva dos seus Órgãos, bem como a utilização dos meios extrajudiciais legalmente atribuídos à Instituição: inquéritos civis e procedimentos preparatórios, compromissos de ajustamento de conduta e recomendações, como instrumentos de  adequação da gestão do sistema público de saúde às diretrizes e aos direitos assegurados na Constituição Federal. São utilizados elementos conceituais, a teoria sobre o Ministério Público demandista e resolutivo e sobre os instrumentos extrajudiciais do MP, a análise de dados primários e secundários, bem como questionários direcionados aos gestores documentais do Ministério Público Federal, com o intuito de analisar em que medida a atuação extrajudicial do Ministério Público Federal tem servido para se alcançar soluções negociadas às demandas na área da saúde pública. Os resultados indicam que o Ministério Público Brasileiro tem avançado na sua atuação extrajudicial, mediante a adoção de estratégias institucionais na busca de resolutividade das demandas coletivas. No caso do Ministério Público Federal, os resultados indicam que a Instituição tem alcançado bons índices de efetividade em relação aos termos de ajustamento de conduta celebrados, evitando a judicialização de questões atinentes à saúde pública.
O fato jurídico do inciso III do artigo 135 do Código Tributário Nacional: a delimitação da responsabilidade tributária do administrador
Authors: Rodrigues de Melo Nunes Danyelle , Lôbo Gomes Filipe , De Santana Barbosa Farias Natalie Cristyne
Published: January 2021

O fato jurídico do inciso III do artigo 135 do Código Tributário Nacional é o resultado da incidência da norma jurídica de responsabilidade tributária sobre o suporte fático praticado pelo administrador. A partir de então, surge a relação jurídica, a obrigação tributária e todos os encargos dela decorrentes. Por esse motivo, é preciso analisar com bastante atenção a norma jurídica que define o fato jurídico tributário. Com base nessas premissas, esse artigo tem como objetivo aplicar a Teoria do Fato Jurídico na análise da responsabilidade tributária para delimitar a sua eficácia. Em linhas gerais, o referencial teórico da pesquisa é o de Pontes de Miranda. Por sua vez, o método de estudo utilizado é o dedutivo, partindo da pesquisa bibliográfica, com base na Teoria do Fato Jurídico de Marcos Bernardes de Mello. Ao final, o trabalho chegou a algumas conclusões bastante elucidativas: 1) o inciso III do artigo 135 do CTN corresponde a um fato jurídico lato sensu, ilícito, relativo, da categoria ato ilícito civil e indenizativo; 2) esse fato jurídico tem como efeito a relação jurídica entre o Estado, a empresa e o administrador; e 3) a responsabilidade tributária do administrador é do tipo solidária, pois a norma jurídica estabelece um comando para garantir o crédito tributário sob um viés arrecadatório e sancionador.
A Declaração de Direitos de Liberdade Econômica e o poder municipal: impactos da Lei 13.874/19 nos municípios brasileiros
Authors: Corralo Giovani Da Silva
Published: January 2021

A pesquisa objetiva o estudo da eficácia jurídica do impacto da Declaração de Direitos de Liberdade Econômica – Lei 13.874/19 – nos municípios brasileiros.  Trata-se de marco legal que entrou em vigor em setembro de 2019 a fim de desburocratizar e liberalizar as atividades econômicas.  Para tanto, é compreendida as competências e a autonomia municipal para normatizar e induzir a atividade econômica local e, na sequência, os impactos da Lei 13.874/19 nos municípios brasileiros, mais especificamente as normas que vinculam a atuação municipal.  Utiliza-se o método hipotético-dedutivo e a hipótese resta confirmada com a demonstração do elevado impacto e eficácia jurídica de normas da Declaração de Direitos de Liberdade Econômica em nível local.
Direito de comunidades tradicionais face ao agronegócio: análise da tutela de direitos desde resistências à monocultura da soja no Baixo Parnaíba maranhense
Authors: Bruzaca Ruan Didier
Published: January 2021

A realidade brasileira é marcada por conflitos decorrentes do modelo de desenvolvimento adotado no país, como os envolvendo o agronegócio, caracterizado por monocultivos, latifúndios e contrastes ambientais e territoriais. Com isso, este trabalho científico tem como tema o impacto do agronegócio sobre os direitos de comunidades tradicionais. De forma delimitada, analisa o contexto do Baixo Parnaíba maranhense com foco na efetividade de direitos daqueles grupos étnicos nos conflitos socioambientais provocados pelo monocultivo da soja. O problema remete à indagação de em que medida as resistências das comunidades tradicionais atingidas pelo agronegócio contribui para a efetividade de direitos. Acolhe-se a hipótese de que as comunidades se contrapõem ao modelo de produção adotado pelos empreendedores do agronegócio, caracterizado por ser ambiental, social e culturalmente prejudicial, repercutindo em outras formas de construir o direito. O objetivo geral é analisar a relação entre o agronegócio e a consagração de direitos de comunidades tradicionais. Especificamente, busca destacar o avanço territorial do agronegócio no Brasil e no Maranhão, apresentar a relação entre o avanço territorial do agronegócio e os impactos sobre o ambiente e os direitos e examinar as implicações da resistência das comunidades tradicionais ao avanço do agronegócio no Baixo Parnaíba maranhense. Realizou-se pesquisa bibliográfica e documental, com levantamento de dados do Instituto Brasileiro de Geografia e Estatística do ano de 2008 a 2016 e do Instituto Brasileiro do Meio Ambiente e dos Recursos Naturais Renováveis a respeito da comercialização de agrotóxicos de 2009 a 2016.
A pobreza como privação de capacitações (capabilites): referências sobre a necessidade de políticas públicas no Brasil em tempos de grave crise
Authors: Zambam Neuro José , Leal Dionis Janner
Published: January 2021

O objetivo deste estudo é abordar a pobreza como privação das capacitações (capabilites) em Amartya Sen e fundamentar a necessária atuação do Estado por meio de políticas públicas para garantir direitos sociais básicos no enfrentamento de períodos de grave crise. Em tempos sombrios, a exemplo da Pandemia Sanitária – Covid-19, demonstra-se a essencialidade e a responsabilidade do Estado em vista do bem comum (art. 1º, III) e a insuficiência do chamado estado mínimo. A CF 88, fundada nos direitos sociais, sintetiza essa prerrogativa. Políticas de assistência integradas demandam a ação coordenada e coletiva, seja dos entes públicos, seja das instituições sociais. A negação dos direitos básicos gera exclusões e impede o desenvolvimento elementar das pessoas. Este estudo, cuja metodologia de abordagem é dedutiva, objetiva abordar a pobreza como privação das capacitações (capabilites) em Amartya Sen e fundamentar a necessária atuação do Estado por meio de políticas públicas para garantir direitos sociais básicos no enfrentamento de períodos de grave crise.
Concepções contemporâneas da democracia
Authors: Albuquerque Armando
Published: January 2021

A democracia como regime de governo remonta há 2.500 anos. Neste decurso, suas instituições sofreram profundas mudanças. Contemporaneamente, a democracia surge em contraposição a todas as formas de regimes não-democráticos, principalmente os totalitários. Mas a teoria democrática não é pacífica. Há pelo menos duas formas de conceber a democracia: uma delas está fundamentada na teoria da democracia de Schumpeter e a outra na definição de Mainwaring. Este é o tema deste artigo.

Palavras-chave: Democracia. Consepções democráticas. Instituições democráticas.
Atuação interdisciplinar do judiciário na produção de provas pessoais por crianças e adolescentes
Authors: Gomes di Lorenzo Lima Wania Claúdia
Published: January 2021

Este artigo tem como objetivo analisar aspectos jurídicos e fatores psicológicos das provas pessoais apresentadas em processo penal, através de depoimentos das crianças e dos adolescentes quando vítimas de abuso sexual. O abuso sexual, na maioria dos casos, não deixa provas materiais e declaração da vítima é primordial para o desfecho processual. Por isso o judiciário brasileiro precisa buscar formas alternativas para inquirir crianças e adolescentes

Palavras-chave: Criança e adolescente. Prova pessoal. Inquirição especial.
Marco regulatório e prestação eficaz de serviço público: pressupostos para o desenvolvimento
Authors: Celino Coutinho Ana Luisa , Nogueira de Queiroz Julian
Published: January 2021

A questão do desenvolvimento insere-se no contexto da discussão acerca do marco regulatório estatal na fiscalização da eficácia na prestação de serviços públicos pela iniciativa privada. A configuração de um modelo de arquétipo estatal regulador implica na superação de concepções clássicas envolvendo o regime jurídico atinente ao serviço público e às atividades econômicas em sentido estrito, visando proporcionar um marco regulatório eficiente no desempenho de um significativo desenvolvimento econômico e social.

Palavras-chave: Regulação. Desenvolvimento. Serviço público.
Recursos pesqueiros da Paraíba
Authors: Ferreira de Andrade José
Published: January 2021

A população oriunda da agricultura terá papel crucial nas próximas décadas, pois as capturas de recursos pesqueiros estão próximas ao limite de exploração sustentável. Há três mil anos, o homem passou de caçador de animais e coletor de vegetais a pastor e agricultor; hoje, os pescadores estão aprendendo que também podem se tornar produtores aquáticos de ambientes continentais marinhos. Com espaço, clima e espécies favoráveis ao cultivo, o Brasil poderá ser um dos maiores produtores de pescado cultivado no mundo.

 

Palavras-chave: Cadeia produtiva. Comercialização. Impactos ecológicos.
O estado ativador do desenvolvimento
Authors: Fernandes dos Anjos Leonardo
Published: January 2021

Estudo dedicado a analisar novas estratégias de promoção do desenvolvimento em que o poder público, em decorrência de uma série de adaptações sofridas no paradigma do Estado Social, procura implementar um modelo de compartilhamento de responsabilidades pela melhoria do bem-estar social com outros entes pertencentes à sociedade civil e ao mercado, na proposta de um Estado ativador do desenvolvimento a partir do estímulo das próprias capacidades dos indivíduos para geração de trabalho e renda.

Palavras-chave: Direito e Desenvolvimento. Estado Social. Estado ativador. Capacidades. Trabalho e renda.
Análise do arcabouço legislativo do álcool combustível no Brasil
Authors: Farias Talden
Published: January 2021

É no contexto da crise ambiental que a busca por energias sustentáveis ganha força. Nesse sentido, o álcool desponta como uma alternativa interessante, especialmente para o Brasil, que possui vastas áreas disponíveis à agricultura, mão de obra abundante e tecnologia. Este trabalho teve como objetivo analisar a regulação jurídica dos biocombustíveis no Brasil com ênfase específica no álcool. Verificou- se a necessidade de um marco jurídico único e atualizado, que traga incentivos mais efetivos para essa modalidade de combustível.

Palavras-chave: Álcool. Biocombustíveis. Biodiesel.
A nova sistemática dos alimentos: expressão de solidariedade familiar e garantia de direitos fundamentais
Authors: Valença Ferraz Carolina , Salomão Leite Glauber
Published: January 2021

A recente Emenda Constitucional nº 66/2010, que modificou o regime jurídico da dissolução do casamento no Brasil, ao estabelecer o divórcio como único instrumento hábil ao desfazimento da união matrimonial indiretamente introduziu importante mudança na sistemática dos alimentos entre cônjuges. Com isso, os alimentos foram finalmente submetidos de forma plena aos preceitos constitucionais como decorrência da solidariedade social e instrumento de tutela da dignidade humana.

Palavras-chave: Direito Civil. Alimentos. Casamento. Solidariedade. Divórcio. Dignidade Humana.
Reflexões sobre a trilogia estrutural do processo
Authors: De Gouvêa Medina Paulo Roberto
Published: January 2021

O texto trata da trilogia estrutural do processo – jurisdição, ação e processo –, enfatizando que tais categorias não traduzem nada de novo e nem se encontram adequadamente motivadas. Daí a necessidade de uma revisão de conceitos quanto aos três elementos, sem, contudo, romper com os cânones da teoria do processo ou adotar uma postura revisionista radical.

Palavras-chave: Teoria geral do processo. Jurisdição, ação e processo. Revisão de conceitos.
Fundamentos constitucionales del derecho de familia en Chile
Authors: Salas Salazar Carolina
Published: January 2021

Atualmente, a norma constitucional altera o conteúdo do Direito, uma modernização das distintas disciplinas jurídicas, que compreendemos a partir da noção de irradiação dos direitos fundamentais. Neste trabalho, ocupo-me de revisar o impacto que esta visão provoca ao Direito de Família no Chile, o que é sinônimo de liberalização, atualização e mudanças na interpretação dessas normas civis, que são dirigidas pelo princípio da dignidade humana.

Palavras-chave: Constituição. Direito de família. Princípios Constitucionais. Direitos Fundamentais. Interpretação Constitucional
Uma análise do voto do ministro Cezar Peluso: direito social à moradia
Authors: Urquiza Baracho Hertha , C. Santos Rodrigo Lucas
Published: January 2021

O artigo tem como objetivo fazer uma análise do voto do Ministro Cezar Peluso, que, em Recurso Extraordinário, decidiu que a penhora do bem de família do fiador foi recepcionada pela Constituição brasileira. É posto o voto e a discussão do Pleno, para depois trabalhar o assunto, relacionando-o ao direito social à moradia. Algumas questões constitucionais estão presentes no texto, como as normas programáticas e a aplicação dos direitos fundamentais nas relações entre privados.Palavras-chave: Bem de família. Direitos sociais. Dignidade humana.