bluuebunny/crossref_metadata_2025 huggingface dataset:
A Machine Learning Architecture Replacing Heavy Instrumented Laboratory Tests: In Application to the Pullout Capacity of Geosynthetic Reinforced Soils
Authors: Ali Tabish , Haider Waseem , Ali Nazakat , Aslam Muhammad
Published: November 2022

For economical and sustainable benefits, conventional retaining walls are being replaced by geosynthetic reinforced soil (GRS). However, for safety and quality assurance purposes, prior tests of pullout capacities of these materials need to be performed. Conventionally, these tests are conducted in a laboratory with heavy instruments. These tests are time-consuming, require hard labor, are prone to error, and are expensive as a special pullout machine is required to perform the tests and acquire the data by using a lot of sensors and data loggers. This paper proposes a data-driven machine learning architecture (MLA) to predict the pullout capacity of GRS in a diverse environment. The results from MLA are compared with actual laboratory pullout capacity tests. Various input variables are considered for training and testing the neural network. These input parameters include the soil physical conditions based on water content and external loading applied. The soil used is a locally available weathered granite soil. The input data included normal stress, soil saturation, displacement, and soil unit weight whereas the output data contains information about the pullout strength. The data used was obtained from an actual pullout capacity test performed in the laboratory. The laboratory test is performed according to American Society for Testing and Materials (ASTM) standard D 6706-01 with little modification. This research shows that by using machine learning, the same pullout resistance of a geosynthetic reinforced soil can be achieved as in laboratory testing, thus saving a lot of time, effort, and money. Feedforward backpropagation neural networks with a different number of neurons, algorithms, and hidden layers have been examined. The comparison of the Bayesian regularization learning algorithm with two hidden layers and 12 neurons each showed the minimum mean square error (MSE) of 3.02 × 10−5 for both training and testing. The maximum coefficient of regression (R) for the testing set is 0.999 and the training set is 0.999 for the prediction interval of 99%.
Despite Good Correlations, There Is No Exact Coincidence between Isometric and Dynamic Strength Measurements in Elite Youth Soccer Players
Authors: Wagner Carl-M. , Warneke Konstantin , Bächer Christoph , Liefke Christian , Paintner Philipp , Kuhn Larissa , Brauner Torsten , Wirth Klaus , Keiner Michael
Published: November 2022

Speed strength performances are substantially dependent on maximum strength. Due to their importance, various methods have been utilized to measure maximum strength (e.g., isometric or dynamic) with discussed differences regarding transferability to sport-specific movements dependent upon the testing procedure. The aim of this study was to analyze whether maximum isometric force (MIF) during isometric back squats correlates with maximum strength measurements of the one repetition maximum (1RM) in the squat, with countermovement jump (CMJ) performance, and with drop jump (DJ) performances in elite youth soccer players (n = 16, 18.4 ± 1.5 [range: 17–23] years old). Additionally, concordance correlation coefficients (CCC, [ρc]) between isometric and dynamic measurements were calculated to verify whether one measurement can actually reproduce the results of the other. To improve comprehension, differences between isometric and dynamic testing values were illustrated by providing differences between both testing conditions. For this, the mean absolute error (MAE) and the mean absolute percentage error (MAPE) were calculated. To reach equality in scale, the 1RM measures were multiplicated by 9.81 to obtain a value of N. The 1RM demonstrated correlations of τ = |0.38| to |0.52| with SJ and CMJ performances, while MIF demonstrated correlations of τ = |0.21| to |0.32|. However, the correlations of both 1RM and MIF with the DJ reactive strength index (RSI = jump height/contact time) from different falling heights were of no statistical significance. The data showed significant correlations between both the absolute (τ = |0.54|) and the relative (τ = |0.40|) performances of 1RM and MIF, which were confirmed by CCC of ρc= |0.56| to |0.66|, respectively. Furthermore, the MAE and MAPE showed values of 2080.87 N and 67.4%, respectively. The data in this study show that, despite good correlations, there is no exact coincidence between isometric and dynamic strength measurements. Accordingly, both measurements may only represent an estimation of maximal strength capacity and cannot be substituted for each other. Therefore, maximal strength should be tested by using high similarity in the contraction condition, as it is used in the training process to counteract underestimation in strength because of unfamiliarity with the testing condition.
Assessing Wind Farm Site Suitability in Bangladesh: A GIS-AHP Approach
Authors: Islam Md Rabiul , Islam Md Rakibul , Imran Hosen M.
Published: November 2022

Wind energy is one of the most attractive renewable energy sources because of its low operating, maintenance, and production costs as well as its low environmental impact. The goal of this study is to discover the best locations in Bangladesh for wind farms to be built and operated efficiently. This study applied the Geographic Information System (GIS) and Analytical Hierarchy (AHP) methodologies to examine the eight important parameters upon which the suitability of locations is highly dependent. This analysis finds that Bangladesh has large regions appropriate for wind farm installation, with 3718.76 km2 and 16,631.14 km2 classified as being of “very high” and “high” suitability, respectively. It was also observed that wind speed, land slope, and elevation each had a height-weighted criterion of 32%, 27%, and 12%, respectively, when picking suitable locations. However, the overall viability of this study in identifying suitable sites has been evaluated based on ROC and AUC techniques and found satisfactory as per AUC value. The knowledge gained from this study will help the sustainable and renewable energy development authority (SREDA) of Bangladesh to expedite the renewable energy investment process and will ensure greater certainty in resource development. The findings of this research can be considered as baseline information for the wind energy sector.
Applications of Solar Panel Waste in Pavement Construction—An Overview
Authors: Sandanayake Malindu , Li Le , Zhao Junhai , Joseph Paul
Published: November 2022

Waste from used solar panels will be a worldwide problem in the near future mainly due to the strong uptake in solar energy and the necessity of disposing solar panel systems at the end–of–life stage, as these materials are hazardous. While new techniques and strategies are often investigated to manage the end–of–life of solar panels effectively, there is huge potential in recycling and reusing solar panel waste as components for alternate products. Numerous studies have been conducted on using alternate materials instead of conventional materials in pavement construction. The current study presents a detailed review and a discussion on using solar panel waste materials in pavement construction. The findings present opportunities to use different solar panel waste materials such as glass, aluminium (Al), silicon (Si), and polymer waste as potential replacement materials in various types of pavement construction. The study also presents the current progress and future focus on experimental developments in pavements with solar panel waste to benchmark short–term and long–term characteristics. Finally, the review discusses the impediments that restrict and the drivers that can facilitate the implementation of solar panel waste in pavement construction. The main findings from this review can be used as a quantitative foundation to facilitate decisions on using different solar panel waste materials in pavement construction applications. Furthermore, such findings will also be beneficial for policymakers and industry stakeholders to implement effective supply chain strategies for promoting solar panel waste as a potential pavement construction material.
Managing Ship’s Ballast Water: A Feasibility Assessment of Mobile Port-Based Treatment
Authors: Ishola Ademola , Kontovas Christos A.
Published: November 2022

The International Maritime Organization (IMO) has adopted the Ballast Water Management Convention (BWMC), which requires vessels to manage their ballast water according to specific standards. While most vessels have to install a management system onboard, in some cases, a mobile solution, for example a system fitted in a container, might be a more viable solution. These mobile systems are an excellent solution as a contingency measure as well, that is when onboard systems malfunction. Research on the topic is rather scant. To that extent, this paper proposes a Bayesian network-based framework to model and assess the feasibility of mobile ballast water treatment solutions. The results based on input from experts indicate that mobile systems are a highly feasible solution. The operational and logistical feasibility of the system are the most important parameters and are areas where the manufacturers and service providers should pay more attention. With compliance deadlines approaching, malfunctions of installed systems increasing and the technology for port-based solutions becoming more mature, there will be increased focus on port-based systems. Our results can, therefore, provide valuable insights to regulators, ship and port operations and we hope that they can spark further academic research on this area.
Investigating the Index of Sustainable Development and Reduction in Greenhouse Gases of Renewable Energies
Authors: Ponkratov Vadim V. , Kuznetsov Alexey S. , Muda Iskandar , Nasution Miftahul Jannah , Al-Bahrani Mohammed , Aybar Hikmet Ş.
Published: November 2022

Considering the limited resources of fossil energy and the problems caused by the emission of greenhouse gases, it is necessary to pay more attention to renewable energies, because in this way, the goals of sustainable development can be achieved. The importance of renewable energies in sustainable development, reducing greenhouse gases and increasing energy security on the one hand, and the need for financial resources and large investments for renewable energy projects on the other hand, doubles the role and importance of financial development in the development of renewable energies. Considering the importance of this issue, the present study examines the impact of the development of modern facilities and renewable energy technology. In this study, dynamic interactions in the Sustainable-Energy-Energy Development Pattern of carbon dioxide are investigated using the Bayesian Vector Auto Regression (BVAR) method. One of the most important indicators for evaluating sustainable development is the modified pure arrangement (GS). For this purpose, this index was used as a sustainable development index. The results indicate that the effect of positive impulse on renewable and renewable energy consumption on sustainable development in Uganda is positive. In addition, the positive shock of renewable and renewable energy consumption increases the emissions of carbon dioxide pollutants to a different extent. In addition, the effect of the growth of sustainable development index on renewable energy consumption and renewal energy consumption is (CO2) negative. The research results show that based on the RMSE criterion, the former SSVS-Full function was used to investigate the impact of renewable energy consumption on sustainable development and the independent Normal-Wish art function was used. Therefore, in this research, the dynamic relationships between sustainable development, energy consumption (separately from renewable and non-renewable energy) and CO2 emissions are investigated.
Dynamic Stability Evaluation of an Integrated Biodiesel-Geothermal Power Plant-Based Power System with Spotted Hyena Optimized Cascade Controller
Authors: Saha Arindita , Dash Puja , Babu Naladi Ram , Chiranjeevi Tirumalasetty , Dhananjaya Mudadla , Knypiński Łukasz
Published: November 2022

The perception of automatic generation control (AGC) has a massive part in delivering eminence power in an interrelated structure. To acquire eminence power by monitoring the fluctuations of frequency and tie-link power, an appropriate controller strategy is essential. This work explores AGC learning under the traditional situation. In this study, we employ a cascade controller with proportional amalgamation with a tilt-integral-derivative with a filter (TIDN) and fractional order integral-derivative (FOID), named TIDN-FOID. In order to acquire the controller’s attributes, a meta-heuristic optimization algorithm spotted hyena optimizer (SHO) is employed. Several investigations express the excellency of the TIDN-FOID controller over other controllers from outlook regarding the lessened level of peak_overshoot, peak_undershoot, and settling_time for the considered structure. The structure comprises thermal, biodiesel units in area 1, thermal, and geothermal units in area-2, and hydrothermal units in area-3. Both biodiesel and GPP have a better effect on system dynamics even in the presence of time delay. Action in the redox flow battery is also examined, providing a noteworthy outcome. Eigenvalue assessment is carried out to comment on the stability of the system. TIDN-FOID parameter values at nominal conditions are appropriate for a higher disturbance value without the need for optimization.
First Report of Field Efficacy and Economic Viability of Metarhizium anisopliae-ICIPE 20 for Tuta absoluta (Lepidoptera: Gelechiidae) Management on Tomato
Authors: Kabaale Fred Peter , Tumuhaise Venansio , Tinzaara William , Turyasingura Geoffrey , Subramanian Sevgan , Khamis Fathiya Mbarak , Akutse Komivi Senyo
Published: November 2022

Eco-friendly pest control options are highly needed in food crop production systems to mitigate the hazards of synthetic chemical pesticides. Entomopathogenic fungal biopesticides—Metarhizium anisopliae strains ICIPE 20 (oil-formulation containing 1.0 × 109 conidia/mL) and ICIPE 69 (commercialized biopesticide known as Mazao Campaign®)—were evaluated against Tuta absoluta on tomato through inundative foliar spray and compared with the commonly used pesticide Dudu Acelamectin 5% EC (Abamectin 20 g/L + Acetamiprid 3%) and untreated plot. All the treatments were arranged in a randomized complete block design with three replicates. The field experiments were conducted for two consecutive cropping seasons in Mukono district, Uganda. Tuta absoluta infestation, injury severity on leaves and fruits, fruit yield loss, marketable fruit yield gain and cost–benefit ratio of the treatments were assessed. The results during both seasons showed a significant lower fruit yield loss in M. anisopliae ICIPE 20-treated plots compared to untreated plots, with a marketable fruit yield gain exceeding 22% and a cost–benefit ratio greater than 2.8 (BCR~3). Dudu Acelamectin 5% EC outperformed all the other treatments, but needs to be considered with caution due to its non-target effect and resistance development, whereas M. anisopliae ICIPE 69 performed the least well. In addition, the findings showed the high degree of efficacy and economic viability of these biopesticides as a potential T. absoluta control option in the field. However, it is important to further explore different formulations of these eco-friendly biopesticides, inoculum delivery approach, application frequency, their effectiveness in different agro-ecological zones and compatibility with commonly used pesticides in tomato production systems for sustainable management of T. absoluta.
A Global Scientometric Visualization Analysis of Rural Tourism from 2000 to 2021
Authors: Su Yue , Mei Jie , Zhu Junhui , Xia Panpan , Li Tan , Wang Cheng , Zhi Junjun , You Shixue
Published: November 2022

Rural tourism, as an emerging industry formed by the integration of various industries, has gradually become an essential method of rural economic development. However, few studies have comprehensively addressed how it develops. This paper aims to reveal the major trends and hotspots in the field of rural tourism in the past two decades. A scientometric visualization analysis was applied to the publications on this theme collected from the Web of Science database between 2000 and 2021. The results are shown as follows: (1) There was an overall increasing trend in rural tourism research globally from 2000 to 2021, with an average increase of 74 papers per year. However, the average citations for these papers are declining in recent years, dropping from 20.1 in 2016 to 13.2 in 2020. China, Spain, and the United States ranked in the top three in terms of the number of papers. (2) The most cited journals were The Journal of Agriculture and Environment, Tourism Planning and Development, and Tourism Management, with an average of 45.62, 39.15, and 29.22 citations, respectively. (3) The research hotspots showed obvious differences and characteristics in the two stages of 2000–2007 and 2007–2021. The sustainable development of rural tourism has become a hot topic, and will play an important role in achieving integrated urban and rural development and rural revitalization.
The COVID-19 Pandemic Response and Its Impact on Post-Corona Health Emergency and Disaster Risk Management in Iran
Authors: Ghotbi Nader
Published: November 2022

This paper examines the COVID-19 pandemic response in Iran and offers speculations on the possible impact of its experience on the future response to other health emergencies and disaster risk management based on the lessons learned. The COVID-19 experience in Iran is unique in several aspects, including the significant role played by the healthcare workers’ sharing and exchange of information through Internet-based networking applications, and a sociocultural environment that was weakening public trust and cooperation in the use of preventive strategies such as less than the optimum wearing of face masks and attending large social gatherings. There was also hesitation in receiving the necessary vaccine doses due to public skepticism over the effectiveness of domestic COVID-19 vaccines. Furthermore, healthcare workers and health services were afflicted with a lack of sufficient manpower and material resources to fight the pandemic. Moreover, a strong and mostly negative influence of political agenda and religious influence on preventive health policies, especially an initial governmental ban on the import and use of Western vaccines and the pressure to hold religious festivals during the outbreaks, were prevalent. The lessons that can be learned from this ongoing crisis include the value of independent healthcare information networks, transparency in the communication of health information to the public to get their trust and cooperation, and an emphasis on the separation of health policies from political and religious interference.
Designation and Certification Strategies for Fungus-Resistant Grape Wines: An Exploratory Study in Italy
Authors: Sillani Sandro , Marangon Francesco , Gallenti Gianluigi , Troiano Stefania , Nassivera Federico , Carzedda Matteo
Published: November 2022

Fungus-resistant grapes (FRGs), or pilzwiderstandfähig (PIWI) in German, are obtained through crossbreeding Vitis vinifera and other Vitis species. FRG adoption is among the most promising strategies to pursue and improve sustainability in the wine industry; however, actual spread and impact on sustainability will largely depend on designation and certification possibilities and procedures for FRG wines, in line with the framework set by the European Union (EU) Regulation 2021/2117. The aim of this study is to discuss the potential impact on consumers’ preferences of four hypothetical designation and certification settings for FRG wines: (I) new names without certification; (II) extended use of the original Vitis vinifera variety names without certification; (III) new names and ad-hoc designations (Protected Designation of Origin, PDO); (IV) extended use of the original Vitis vinifera variety names and existing PDOs. Participants’ reactivity to the alternatives was tested through market simulations on a non-probabilistic sample of 301 Italian university students. According to the results, extension of existing names and PDOs is the best option to enhance industry sustainability, preserve its quality paradigm, and fairly manage competition between traditional and new wines. Still, further investments are needed to promote FRG adoption and development.
Sea Minerals Reduce Dysbiosis, Improve Pasture Productivity and Plant Morphometrics in Pasture Dieback Affected Soils
Authors: Whitton Maria M. , Ren Xipeng , Yu Sung J. , Irving Andrew D. , Trotter Tieneke , Bajagai Yadav S. , Stanley Dragana
Published: November 2022

Pasture dieback (PD) is a grassland deteriorating syndrome resulting in grass loss and weed expansion in Australian pastures, with current estimates indicating that over four million hectares are affected. PD creates financial losses to the industry by reducing animal carrying capacity and producing poor-quality feed, resulting in diminished productivity. After more than a decade since PD first appeared in Australia, the causes and effective treatments are still unknown. Suggested causes include soil microbiota dysbiosis, pathogens, insects, climate change and overuse of chemical fertilisers. Sea minerals have been suggested as capable of improving plants’ yield, quality, taste, and nutritional value, but were never brought into conventional practice as an alternative to chemical fertilisers. Here, we investigated the capacity of sea minerals to improve grass health and yield of PD-affected soil. The replicate plots were treated with water or with 4 mL/m2 of commercially available sea mineral product to investigate the soil chemistry profile, plant morphometrics, pasture productivity, soil microbiota profile, and microbiota-nutrient interactions. Sea mineral application significantly increased total dry matter 20 weeks after a single application, translating to an additional 967 kg/ha; this benefit was still present at 498 kg/ha eleven months post a single application. Sea mineral application improved soil microbiota by boosting beneficial taxa while reducing genera associated with arid and toxic soils. Additionally, sea mineral application increased the number of grassroots up to eleven months post a single application. Our data suggest the benefits of sea mineral application to damaged, unproductive or exhausted soils could be further explored as a natural, affordable, and non-toxic alternative to chemical fertilisers.
The Development of Sustainable Social Farming in Italy: A Case Studies Analysis
Authors: Moruzzo Roberta , Granai Giulia , De Benedictis Caterina , Galardi Morgana , Colosimo Vincenzina , Sforzi Jacopo , Di Iacovo Francesco
Published: November 2022

Social Farming (SF) is a rising practice that offers various typologies of initiatives involving different actors. Peculiarities consist of the types of networks organized at the territorial level and in the innovation processes they implement. In this study, through a cross-case analysis, we take into account six Italian social farms as case studies, interviewing them to understand the activities provided and their organization with the aim of highlighting both the strengths and the criticalities that may limit possible further development of Social Farming in Italy. The results of the analysis pointed out the specificities of the services offered by the social farms and the points of view of the farmers in the sector. Reflecting on these cases in light of the innovation system theory, it was possible to understand both the innovation system in which they developed and the enabling and the limiting aspects for Social Farming initiatives, as well as to codify useful lessons regarding the future organization of sustainable Social Farming services.
Government Reserve of Rare Earths under Total Quota Management: An Interactive Game between Government and Rare-Earth Firms
Authors: Chen Jianyun , Zhu Wenxing , Luo Xianping
Published: November 2022

The total quota control and reserve of rare earths are important means for the sustainable development and utilization of rare-earth resources. Focusing on the government reserve of rare-earth products under stochastic demand, this paper analyses the interactive decisions of the government and the rare-earth firms from a game-theoretic perspective. The government determines the total quantity, reserve quantity and reserve–release quantity of the rare-earth products to maximize social warfare, while the firm decides the price of rare-earth products to maximize its own profit. The results show that the production cost and the expected net present value (NPV) of the reserve are important factors affecting the government’s decisions. When the expected NPV of the reserve is below a threshold, the government adopts the no-reserve strategy: it determines only a total quota index that maximizes the current-period social welfare but keeps no reserve. When the expected NPV of a reserve is higher than the above threshold but lower than the production cost, the government adopts the low-reserve strategy: it determines a total quota index and a low reserve that are both in increasing in the expected NPV of reserve, and will release the reserve as many as possible if there is a supply shortage. When the expected NPV of a reserve is higher than both the above threshold and the production cost, the government adopts the high-reserve strategy: it sets a total quota index which is sufficiently large to cover the entire market demand, reserves a large amount, and releases part of the reserve to completely fill the demand gap (if any).
Testing the Psychometric Properties and Measurement Invariance of the Perceived Motivational Climate in Sport Questionnaire (PMCSQ-2): Online Assessment
Authors: Pérez-Romero Nuria , Reigal Rafael E. , Franquelo María Auxiliadora , Balaguer Isabel , Falcó Coral , Hernández-Mendo Antonio , Morales-Sánchez Verónica
Published: November 2022

Athletes’ perception of competence and success can be influenced by the motivational climate created by the coach. The Perceived Motivational Climate in Sport Questionnaire (PMCSQ-2) assesses this. Although its reliability and validity have been analyzed in previous studies, this has never been done for the online version. This type of evaluation can be beneficial for data collection, sustainability, speed, and generating larger samples. Therefore, the aim of this study is to analyze the psychometric properties of the PMCSQ-2 in its online version. The sample consisted of 1637 participants (37.8% men and 62.2% women) from 18 to 68 years of age (M = 24.39, SD = 6.51) who practiced physical-sport activities regularly. A second-order confirmatory factor analysis (CFA) model and its invariance for gender were studied from a 24-item version obtained from the MenPas 1.0 platform. The analyses provided an adequate fit for the CFA (CFI = 0.91, TLI = 0.90, RMSEA = 0.07, SRMR = 0.07, df = 224, B-S p = 0.02–0.07) when an alternative model was realized (χ2 = 1858.89, χ2/df = 8.30), as they also did for the women (χ2 = 1356.90, χ2/df = 6.06), men (χ2 = 883.58, χ2/df = 3.95) individual sports (χ2 = 1153.55, χ2/df = 5.15), and team sports (χ2 = 1008.92, χ2/df = 4.05) items. The data were also suitable for invariance analysis. Similarly, appropriate values were obtained for convergent and discriminant validity and for composite reliability. Therefore, the results obtained show appropriate psychometric properties for the online version of the PMCSQ-2 using an alternative model, suggesting that its use is suitable for research and showing the importance of the subscales.
Correction: Caprari et al. Digital Twin for Urban Planning in the Green Deal Era: A State of the Art and Future Perspectives. Sustainability 2022, 14, 6263
Authors: Caprari Giorgio , Castelli Giordana , Montuori Marco , Camardelli Marialucia , Malvezzi Roberto
Published: November 2022

The authors would like to make the following corrections to the published paper [...]
Reliability Inferences of the Inverted NH Parameters via Generalized Type-II Progressive Hybrid Censoring with Applications
Authors: Elshahhat Ahmed , Mohammed Heba S. , Abo-Kasem Osama E.
Published: November 2022

Generalized progressive hybrid censored mechanisms have been proposed to reduce the test duration and to save the cost spent on testing. This paper considers the problem of estimating the unknown model parameters and the reliability time functions of the new inverted Nadarajah–Haghighi (NH) distribution under generalized Type-II progressive hybrid censoring using the maximum likelihood and Bayesian estimation approaches. Utilizing the normal approximation of the frequentist estimators, the corresponding approximate confidence intervals of unknown quantities are also constructed. Using independent gamma conjugate priors under the symmetrical squared error loss, the Bayesian estimators are developed. Since the joint likelihood function is obtained in complex form, the Bayesian estimators and their associated highest posterior density intervals cannot be obtained analytically but can be evaluated via Monte Carlo Markov chain techniques. To select the optimum censoring scheme among different censoring plans, five optimality criteria are used. Finally, to explain how the proposed methodologies can be applied in real situations, two applications representing the failure times of electronic devices and deaths from the coronavirus disease 2019 epidemic in the United States of America are analyzed.
(I, JP) = (1, 1/2+)ΣNN Quasibound State
Authors: Garcilazo Humberto , Valcarce Alfredo
Published: November 2022

JLab has recently found indications of the possible existence of a ΣNN resonance at (3.14±0.84)−i(2.28±1.2) MeV. In the past, using models that exploit symmetries between the two-baryon sector with and without strangeness, hyperon–nucleon interactions that reproduce the experimental data of the strangeness −1 sector have been derived. We make use of these interactions to review the existing Faddeev studies of the ΛNN−ΣNN system that show theoretical evidence of a (I,JP)=(1,1/2+)ΣNN quasibound state near the threshold. The calculated position of the pole is at 2.92−i2.17 MeV, which is in reasonable agreement with the experimental findings.
Developing a Stochastic Two-Tier Architecture for Modelling Last-Mile Delivery and Implementing in Discrete-Event Simulation
Authors: Lyu Zichong , Pons Dirk , Chen Jiasen , Zhang Yilei
Published: November 2022

Modelling freight logistics is challenging due to the variable consignments and diverse customers. Discrete-event Simulation (DES) is an approach that can model freight logistics and incorporate stochastic events. However, the flexible delivery routes of Pickup and Delivery (PUD) are still problematic to simulate. This research aims to develop last-mile delivery architecture in DES and evaluate the credibility of the model. A two-tier architecture was proposed and integrated with a DES model to simulate freight operations. The geographic foundation of the model was determined using Geographic Information Systems (GIS), including identifying customer locations, finding cluster centres, and implementing Travelling Salesman Problem (TSP) simulation. This complex model was simplified to the two-tier architecture with stochastic distances, which is more amenable to DES models. The model was validated with truck GPS data. The originality of the work is the development of a novel and simple methodology for developing a logistics model for highly variable last-mile delivery.
Novel RNA Viruses Discovered in Weeds in Rice Fields
Authors: Chao Shufen , Wang Haoran , Zhang Shu , Chen Guoqing , Mao Chonghui , Hu Yang , Yu Fengquan , Wang Shuo , Lv Liang , Chen Long , Feng Guozhong
Published: November 2022

Weeds often grow alongside crop plants. In addition to competing with crops for nutrients, water and space, weeds host insect vectors or act as reservoirs for viral diversity. However, little is known about viruses infecting rice weeds. In this work, we used metatranscriptomic deep sequencing to identify RNA viruses from 29 weed samples representing 23 weed species. A total of 224 RNA viruses were identified: 39 newly identified viruses are sufficiently divergent to comprise new families and genera. The newly identified RNA viruses clustered within 18 viral families. Of the identified viruses, 196 are positive-sense single-stranded RNA viruses, 24 are negative-sense single-stranded RNA viruses and 4 are double-stranded RNA viruses. We found that some novel RNA viruses clustered within the families or genera of several plant virus species and have the potential to infect plants. Collectively, these results expand our understanding of viral diversity in rice weeds. Our work will contribute to developing effective strategies with which to manage the spread and epidemiology of plant viruses.
Monoclonal Antibodies against SARS-CoV-2 Infection: Results from a Real-Life Study before the Omicron Surge
Authors: Scotto Riccardo , Buonomo Antonio Riccardo , Zumbo Giulia , Di Fusco Antonio , Esposito Nunzia , Di Filippo Isabella , Nobile Mariano , Pinchera Biagio , Schiano Moriello Nicola , Villari Riccardo , Gentile Ivan ,   Federico II COVID Team
Published: November 2022

Despite the lightning-fast advances in the management of SARS-CoV after 2 years of pandemic, COVID-19 continues to pose a challenge for fragile patients, who could benefit from early administration of monoclonal antibodies (mAbs) to reduce the risk of severe disease progression. We conducted a prospective study to evaluate the effectiveness of mAbs against SARS-CoV-2 among patients at risk for severe disease progression, namely elderly and those with comorbidities, before the omicron variant surge. Patients were treated with either casirivimab/imdevimab, sotrovimab, or bamlanivimab/etesevimab. The rates and risk factors for clinical worsening, hospitalization, ICU admission and death (unfavorable outcomes) were evaluated. A stratified analysis according to the presence of SARS-CoV-2 IgG was also performed. Among 185 included patients, we showed low rates of unfavorable outcomes (9.2%), which were more frequent in patients with chronic kidney disease (aOR: 10.44, 95% CI: 1.73–63.03; p < 0.05) and basal D-dimer serum concentrations > 600 ng/mL (aOR 21.74, 95% CI: 1.18–397.70; p < 0.05). Patients with negative SARS-CoV-2 serology at baseline showed higher C-reactive protein values compared with patients with positive serology (p < 0.05) and a trend toward a higher admission rate to SICU and ICU compared with patients with positive serology. Our results thus showed, in a real-life setting, the efficacy of mAbs against SARS-CoV-2 before an Omicron surge when the available mabs become not effective.
Early Real-World Data to Assess Benefits and Risks of COVID-19 Vaccines: A Systematic Review of Methods
Authors: Ribeiro Tatiane B. , Roque Fátima , Ida Fidelia , Plácido Ana I. , Vu Mai , Hernández-Muñoz Jose J. , Herdeiro Maria Teresa
Published: November 2022

Since the authorization of the first COVID-19 vaccines in December 2020, multiple studies using real-world data (RWD) have been published to assess their effectiveness/safety profile. This systematic review aimed to characterize the methods and outcomes of studies using RWD for assessment of COVID-19 vaccines, four months after vaccine approval. MEDLINE and EMBASE were searched to identify published studies until 6 May 2021. Two independent researchers selected relevant publications and extracted data from included studies. The risk of bias was assessed using New-Castle Ottawa tools. After screening 1086 studies, 15 were included. Out of the 15 studies, 12 (80%) followed a cohort design, 8 (53%) were based on USA data, 7 (47%) assessed health care professionals, and 14 articles (93%) assessed the BNT162b2 vaccine. Data sources included institutional databases, electronic health records, and patient-generated data. The primary endpoint mainly described was SARS-CoV-2-infection. Hospitalization and mortality were assessed in 2 studies. For the comparability domain, six studies (40%) had a high risk of bias. A few months after the beginning of COVID-19 vaccination, Real-world Evidence (RWE) provided timely safety surveillance and comparative effectiveness with findings that showed similar findings to Randomized control trial (RCT). Most of the initiatives assessed BNT162b2 and were conducted in the USA and used healthcare workers’ data.
Hesitancy toward the Full COVID-19 Vaccination among Kidney, Liver and Lung Transplant Recipients in Italy
Authors: Costantino Andrea , Morlacchi Letizia , Donato Maria Francesca , Gramegna Andrea , Farina Elisa , Dibenedetto Clara , Campise Mariarosaria , Redaelli Matteo , Perego Marta , Alfieri Carlo , Blasi Francesco , Lampertico Pietro , Favi Evaldo
Published: November 2022

Background: Coronavirus disease 2019 (COVID-19) vaccination hesitancy is a threat as COVID-19 vaccines have reduced both viral transmission and virus-associated mortality rates, particularly in high-risk subgroups. Solid organ transplant recipients (SOTRs) are particularly vulnerable, as the underlying causes of their organ failure and the chronic immunosuppression are associated with a lower immune response to COVID-19 vaccines, and with an excessive risk of death due to SARS-CoV-2 infection. We aimed to evaluate COVID-19 vaccination hesitancy and its reasons in a population of SOTRs. Methods: All the SOTRs attending our post-transplant clinics were asked to fill in a vaccination status form with specific validated questions related to their willingness to receive a third vaccine dose. In the case of negative answers, the patients were encouraged to explain the reasons for their refusal. Among the SOTRs (1899), 1019 were investigated (53.7%). Results: Overall, 5.01% (51/1019) of the SOTRs raised concerns regarding the future third dose vaccination. In more detail, hesitancy rates were 3.3% (15/453), 4.2% (7/166), and 7.3% (29/400) among the investigated liver, lung, and kidney transplant recipients, respectively (p = 0.0018). The main reasons for hesitancy were fear of adverse events (30/51, 58.8%) and perceived lack of efficacy (21/51, 41.2%). Conclusions: Full adherence to ongoing or future vaccination campaigns is crucial to prevent, or at least reduce, COVID-19-related morbidity and mortality in fragile patients. The identification of the reasons influencing COVID-19 vaccination hesitancy in these patients is very important to establish appropriate and targeted patient–doctor communication strategies, and to further implement specific vaccination campaigns.
Immunomodulatory Role of Thioredoxin Interacting Protein in Cancer’s Impediments: Current Understanding and Therapeutic Implications
Authors: Katturajan Ramkumar , Nithiyanandam Sangeetha , Parthasarathy Manisha , Valsala Gopalakrishnan Abilash , Sathiyamoorthi Ezhaveni , Lee Jintae , Ramesh Thiyagarajan , Iyer Mahalaxmi , Prince Sabina Evan , Ganesan Raja
Published: November 2022

Cancer, which killed ten million people in 2020, is expected to become the world’s leading health problem and financial burden. Despite the development of effective therapeutic approaches, cancer-related deaths have increased by 25.4% in the last ten years. Current therapies promote apoptosis and oxidative stress DNA damage and inhibit inflammatory mediators and angiogenesis from providing temporary relief. Thioredoxin-binding protein (TXNIP) causes oxidative stress by inhibiting the function of the thioredoxin system. It is an important regulator of many redox-related signal transduction pathways in cells. In cancer cells, it functions as a tumor suppressor protein that inhibits cell proliferation. In addition, TXNIP levels in hemocytes increased after immune stimulation, suggesting that TXNIP plays an important role in immunity. Several studies have provided experimental evidence for the immune modulatory role of TXNIP in cancer impediments. TXNIP also has the potential to act against immune cells in cancer by mediating the JAK-STAT, MAPK, and PI3K/Akt pathways. To date, therapies targeting TXNIP in cancer are still under investigation. This review highlights the role of TXNIP in preventing cancer, as well as recent reports describing its functions in various immune cells, signaling pathways, and promoting action against cancer.
A Case Report of Monkeypox in an Adult Patient from Italy: Clinical and Dermoscopic Manifestations, Diagnosis and Management
Authors: Proietti Ilaria , Santoro Paolo Emilio , Skroza Nevena , Tieghi Tiziana , Bernardini Nicoletta , Tolino Ersilia , Dybala Agnieszka Ewa , Di Guardo Antonio , Rallo Alessandra , Di Fraia Marco , Rossi Maria Francesca , Vitiello Martina , Moscato Umberto , Pellacani Giovanni , Lichtner Miriam , Potenza Concetta
Published: November 2022

Monkeypox infection is an emerging problem and a new challenge for modern medicine. With an increasing number of new cases worldwide, new data regarding the clinical manifestations, characteristics of the patients, risk factors and treatment options are coming to light. Knowing more about the disease will allow to elaborate new helpful methods to facilitate its diagnosis. Special attention should be paid to the careful dermatologic and dermoscopic examination of the patient. The analysis of available data also suggests possible strategies for the prevention of Monkeypox virus spread; the vaccine against Smallpox seems to be an effective solution. This case report describes the diagnostic approach and management of a non-vaccinated adult patient with several risk factors and a history of sexually transmitted disease. The patient had no history of travel abroad. Even though a clinical diagnose of Monkeypox can be challenging due to its similarities with skin rashes caused by other Orthopoxviral infections, there are fine differences between the rashes which can be helpful in their differentiation, although laboratory analysis is required for a definitive identification. A careful study of the characteristics of the rash, such as diameter, its presence on palms and soles and its evolution in time, provided important clues for the diagnosis of Monkeypox infection. The lack of vaccinations in the history of the patient was another crucial finding in the diagnostic process.
Correlation of Binding and Neutralizing Antibodies against SARS-CoV-2 Omicron Variant in Infection-Naïve and Convalescent BNT162b2 Recipients
Authors: Fu Jia , Shen Xiaoying , Anderson Mark , Stec Michael , Petratos Tia , Cloherty Gavin , Montefiori David C. , Landay Alan , Moy James N.
Published: November 2022

In vaccine clinical trials, both binding antibody (bAb) levels and neutralization antibody (nAb) titers have been shown to be correlates of SARS-CoV-2 vaccine efficacy. We report a strong correlation bAb and nAb responses against the SARS-CoV-2 Omicron (BA.1) variant in infection-naïve and previously infected (convalescent) individuals after one and two doses of BNT162b2 vaccination. The vaccine-induced bAb levels against Omicron were significantly lower compared to previous variants of concern in both infection-naive and convalescent individuals, with the convalescent individuals showing significantly higher bAb compared to the naïve individuals at all timepoints. The finding that bAb highly correlated with nAb provides evidence for utilizing binding antibody assays as a surrogate for neutralizing antibody assays. Our data also revealed that after full vaccination, a higher percentage of individuals had undetectable Omicron nAb (58.6% in naive individuals, 7.4% in convalescent individuals) compared to the percentage of individuals who had negative Omicron bAb (0% in naive individuals, 0% in convalescent individuals). The discordance between bAb and nAb activities and the high degree of immune escape by Omicron may explain the high frequency of Omicron infections after vaccination.
Evaluation of Resting Serum Bile Acid Concentrations in Dogs with Sepsis
Authors: Baptista Lara , Pollard Danica , Di Bella Andrea
Published: November 2022

Recent studies in the human literature suggest that serum bile acid concentrations could be an early predictor of short-term survival in critically ill patients. However, there is no available information in the veterinary literature regarding serum bile acid concentrations in dogs with sepsis. We aimed to evaluate if resting serum bile acid concentrations differ between septic and non-septic dogs. This was a retrospective observational study, of medical records at a single referral center over a twelve-year period. Twenty-six client-owned dogs diagnosed with sepsis were identified. Twenty-one dogs presenting with a non-hepatobiliary systemic disease and twenty-nine dogs admitted for an elective orthopedic procedure, considered otherwise healthy, were selected as control groups. Resting serum bile acid concentrations were significantly higher in the septic compared to the non-septic groups (ill control and orthopedic control groups). However, when assessing bile acid concentrations between groups individually, no difference was identified between the septic and the orthopedic control group. These results should be interpreted cautiously.
Predicting Youth Information Management in Emerging Adulthood from Parental Mindfulness and Social Support
Authors: Goldstein Sara E. , Gunn John F. , Park Jeanie , Paldi Romi , Greiner Csilla
Published: November 2022

The current study examines associations between mindful parenting, family support, and youth information management practices (disclosure, lying, and secrecy) in a diverse sample of college-attending emerging adults (n = 304). Participants were recruited through college classes, and students completed surveys in classrooms or in nearby campus spaces. Data were analyzed to assess for the potential interactive implications of parental mindfulness and support. Results indicate that both parenting variables are important to consider when conceptualizing emerging adults’ information management. Youth who reported the highest levels of parental mindfulness and support also disclosed the most to their parents about their daily activities. In contrast, youth who reported the lowest levels of mindfulness and support lied the most to their parents. Low support was also associated with increased secrecy. Results suggest that parent-youth relationships continue to be important through the emerging adult developmental period, especially in terms of promoting communication practices that can help youth adjust to their increasingly complex worlds.
RELATIONSHIP BETWEEN INDICATORS OF SPECIAL PHYSICAL TRAINING OF FREESTHETIC ATHLETES
Authors: VOVK I. , RAMIK T.
Published: November 2022

The main goal is to increase the level of special physical training of athletes in wrestling by experimental methods, which combined the game and circuit method in the training process. To increase the level of special physical training of wrestlers, weused the experimental method in combination with the game method with the circuit method, and in the control group the main method was used only the circuit method of training. The ratio of indicators before and after the pedagogical experiment is positive dynamics in both experimental and control groups for most tests, the experimental group was at a higher level than the control for the test «Running around the head 10 times», «Coups from head to toe on the carpet «(10-10-10)» and «Exercise» passage to the feet «10 times».