bluuebunny/crossref_metadata_2025 huggingface dataset:
O Museu do Balseiro de Itá como patrimônio cultural de Santa Catarina
Authors: Zen Ana Maria Dalla , Fontanari Lilian Santos da Silva
Published: August 2019

O objetivo deste trabalho é refletir sobre os sentidos e usos associados à preservação da prática dos balseiros que atuaram na década de 1920 em Itá, Santa Catarina, cujos saberes e fazeres vêm sendo (re)afirmados pelo Museu do Balseiro e de como o turismo local tem sido trabalhado no campo do patrimônio cultural. Apesar dos impactos da ação madeireira no meio ambiente, esse ofício se constitui em patrimônio cultural da região, pela produção de artefatos, meios de transporte e ferramentas de trabalho, fundamentado teoricamente na Museologia Social, Nova Museologia e Educação Para o Patrimônio. A metodologia inclui pesquisa documental de roteiro turístico e cultural que citam o museu, desenvolvidos pela Secretaria de Turismo, bem como de um projeto escolar, como referência para montagem de uma réplica de balsa, feita por alunos da Escola Municipal Valentim Bernardi. Analisa o impacto do turismo na patrimonialização do ofício do balseiro e os resultados da experiência como ação de educação para o patrimônio, a partir de relatos da coordenadora do projeto e alunos participantes, reunidos no momento de seu reencontro com a obra exposta no Museu. Discute as relações entre patrimônio cultural, Turismo e Educação para o Patrimônio, a fim de compreender o lugar que cultura e patrimônio ocupam em uma cidade turisticamente explorada. Problematiza as ações turísticas focadas nos espaços culturais, de recuperação e de preservação do patrimônio cultural dos balseiros na rede de ensino, e como estas têm sido negociadas e associadas à história local. Conclui que o turismo em Itá tem objetivos meramente econômicos e que desconhece a experiência de patrimonialização do ofício de balseiro como estratégia de recuperação de memórias e de educação para o patrimônio, por meio da apropriação de elementos da cultura do colonizador.
Caracterização microbiológica em ambiente específico de uma biblioteca universitária em sua composição e qualidade
Authors: Portela Patricia de Oliveira , Kozusny-Andreani Dora Inés
Published: August 2019

A conservação e a preservação do material informacional de uma biblioteca são primordiais para prolongar a vida útil dos seus suportes de informação garantindo a integridade da memória histórica, científica e técnica para as gerações futuras. Com o objetivo de caracterizar os microrganismos em um ambiente específico de uma biblioteca universitária que possam causar a deterioração do acervo e possíveis agravos à saúde de seus frequentadores, foi proposto este estudo de abordagem qualitativa e quantitativa, de natureza aplicada e procedimento experimental. Para a pesquisa foram colhidas amostras de 24 livros e amostras do ar do local definido. Todas as amostras foram cultivadas em Placas de Petri contendo meios seletivos e não seletivos para bactérias e fungos, incubadas à temperatura de 37 ºC por 24-48h para cultivos bacterianos e de 4 a 15 dias para cultivos fúngicos. Posteriormente, foram realizadas a contagem e a avaliação das características das colônias bem como a identificação por métodos bioquímicos convencionas. Os resultados obtidos evidenciaram a presença de bolores, leveduras e bactérias. Verificaram-se variações numéricas quanto à presença de microrganismos nas superfícies dos livros e no ambiente, sendo a contagem microbiana do ar significativamente superior à encontrada nos livros, embora estes tenham apresentado maior variedade de microrganismos identificados.
MICROALGAS PLANCTÓNICAS EN LA LAGUNA COSTERA «EL CARMEN», CÁRDENAS, TABASCO, MÉXICO
Authors: Campos Campos Bernardita , Cortés Lara María del Carmen , Rivas Acuña Ma. Guadalupe
Published: August 2019

Se realizaron tres muestreos en la laguna costera «El Carmen» (Cárdenas, Tabasco) en octubre de 2015, febrero y julio de 2016. Se ubicaron cinco localidades para la obtención del material biológico, se realizaron arrastres subsuperficiales durante 2.5 min en cada localidad con una red para fitoplancton de 60 µm de abertura de malla. Las muestras recolectadas se fijaron con una solución de Lugol ácido. Se identificaron 59 taxones ubicados en cuatro grupos: Cianobacteria, Bacillariophyta (diatomeas), Chlorophyta y Dinophyta, incluidas en siete clases, 31 familias, 42 géneros y 46 especies. Bacillariophyta fue el phylum más abundante con 44 taxones. Se identificaron siete microalgas asociadas a Florecimientos Algales Nocivos (FAN). La mayor riqueza se registró en las localidades con influencia marina y zonas de mezcla. Los datos derivados de este trabajo permiten actualizar la información existente sobre la composición fitoplanctónica de la laguna El Carmen.

Palabras clave: Laguna costera; plancton; Lugol; FAN.

Keywords: Coastal lagoon; plankton; Lugol; FAN.
Study of Animal-Based Food Product Labeling use
Authors: Wibowo Candra Pungki , Syahlani Suci Paramitasari , Nurtini Sudi
Published: August 2019

This study was conducted to identify the food labeling profile in animal-based food products based on consumers’ age and gender, consumers’ preference of the information provided in the label, consumers’ behavior in reading the label, and consumers’ knowledge about food labeling. A total of 100 respondents participated in the study. The sampling was done by using judgmental sampling method with the following criteria: (1) respondent has bought animal-based food products within the last month of the study; (2) respondent’s age was over 18 years old. The data were analyzed descriptively and by using regression analysis. The results showed that female respondents and a group of 50 years or older respondents were used to read the food label frequently compared to other respondent groups. The type of information which considered as the most important was the expiration date, followed by product’s name, ingredients, halal status, nutritional value, product’s instruction for usage and its irregularities, net weight, and the producer’s name and address. This study also identified that the majority of the respondents, as many as 67%, already had good knowledge about food labels, while the other 32% had adequate knowledge, and only 1% of the respondents had a little knowledge about food labels. It can be concluded that consumers’ perception of the potential risks on animal-based food products affect their behaviour in reading the label (p<0.05) while consumers’ health condition and time availability to buy the products did not affect their behaviour in reading the label in animal based food products.
The Production Characteristics of Male Bandicoot (Echymipera kalubu)
Authors: Pawere Frandz Rumbiak , Saragih Desni Triana
Published: August 2019

The aim of this research is to understand the production characteristics of male bandicoot (Echymipera kalubu) and obtain basic morphometric information for cultivation and development of the animal. The research was done through the explorative method by using 30 random undomesticated adult male Echymipera kalubu obtained in Manokwari regency forest, West Papua. The morphometric characteristics of Echymipera kalubu in regards to the body weight and carcass weight are yet to be observed and standardized for practical use. The obtained estimator variables were analyzed by SPSS 24 for windows to calculate the multiple regression and coefficient of correlation value. The results of statistical analysis showed that there were 4 estimator variables that had positive correlations, which were body length (X1), hind legs length (X2), heart girth (X4), and cannon girth (X5). The obtained body weight regression formula was Y1 = -1367.355 + 33,912X1 + 7,095X2 + 89,745X4 – 14,494X5 with the coefficient of determination at 0.815. Moreover, the obtained carcass weight regression formula was Y2 = -1282,170 + 40,113X1 + 7,666X2 + 66,750X4 - 24,231X5 with the coefficient of determination at 0.794. The research concluded that the best estimator variable for body weight and carcass weight was the heart girth.
Toxicity Effect by Binahong (Anredera cordifolia) Leaf Extract in Histopathology and Liver Weight of Guinea Pigs (Cavia cobaya)
Authors: Wijayanti Dwi , Kurnianto Edy , Setiatin Enny Tantini
Published: August 2019

The aim of this research was to determine the toxic effect of Anredera cordifolia leaf extract on the Cavia cobaya liver which was evaluated by the histopathological examination of liver tissue. The materials used were 8 female guinea pigs 2.5 months old that were divided into 4 groups by simple random sampling, each treatment was given to 2 female C. cobaya. Treatments given were 0, 10, 50 and 90 mg of A. cordifolia leaf extract/head, designated as T0, T1, T2 and T3, respectively. Materials were given treatment daily as long as 10 days prepartum. All of the guinea pigs were slaughtered at day 11, and the liver were taken to examined their histopathological changes. Each of the liver tissues were processed by paraffin block-embedded and hematoxylin eosin (HE) staining method. The results of this study indicate the presence of albuminosa degeneration or mild degeneration (DH +) from group control and hydropic degeneration or moderate degeneration (DH ++) in all treatment groups and the weight of C. cobaya liver which was given an extract of A. cordifolia 50 mg/head was not significantly different from the control but was significantly different from 10 and 90 mg/head. The conclusion was Binahong's (A. cordifolia) leaves extract up to the dosage 90 mg/head had no significantly toxicity effect on the liver of guinea pigs (C. cobaya).
Reinforced Concrete under the Action of Carbonization and Chloride Aggression: a Probabilistic Model for Service Life Prediction
Authors: Leonovich S. N. , Shalyi E. E. , Kim L. V.
Published: August 2019

Reinforcement corrosion of marine and coastal hydraulic structures due to chloride aggression and concrete carbonization leads to a sharp decrease in structure safety. The reinforcement is subjected to a depassivation process as soon as a chloride concentration on its surface exceeds a certain threshold concentration, or the pH value in a concrete protective layer is decreased to a threshold value due to carbonation. Electrochemical reactions are realized with formation of corrosion products due to penetration of oxygen up to reinforcement surface. This leads to cracking of the concrete protective layer and decrease in reinforcement cross-section. The paper proposes a method for predicting a complex degradation of reinforced concrete structures with due account of various mechanisms of corrosion wear that allows to develop efficient methods for improvement of structure durability and maintainability which are operated in the marine environment. A methodology for forecasting of reinforced concrete service life prediction has been developed under a combined effect of carbonization and chloride aggression while using finite-difference and probability models. The paper takes into account initiation periods of reinforcement corrosion and propagation periods for conditions of Sakhalin shelf zone. Field surveys of Kholmsk and Korsakov port facilities are presented in the paper. Carbonization front and chloride content have been estimated according to depth of the concrete protective layer. The paper proposes a model that allows to determine an average period prior to repair while taking into account rate of concrete protective layer degradation caused by simultaneous action of two corrosion processes: carbonization and chloride aggression.
About Synergistic Effect of Lubricant and Chemical Additives on Obtaining Quality Surface of Concrete Products
Authors: Yukhnevskiy P. I. , Dimitriadi N. P.
Published: August 2019

The paper substantiates scientific background for development of lubricant compositions used in moulds for concrete products with high-quality surface. It has been shown that consideration of interaction between air bubbles, lubricant and liquid phase of modified concrete is of great importance. A release agent must allow air to migrate to a certain extent and leave “formwork – concrete mix” interface. In this regard the lubricant must have low viscosity. In addition, the lubricant should give maximum hydrophobization to a mould and have minimal adhesion in respect of the concrete mix. Additives of hydrophobic substances in liquid lubricants significantly reduce surface porosity of products. Chemical plasticizing additives and, in particular, additives of polycarboxylate type substantially reduce surface tension of liquid sгж, thereby they significantly reduce work for fixing an air bubble on concrete surface and contribute to its ejection. In addition, adsorbed molecules of the chemical additives interfere with interaction of cement paste particles and mould surface. Polycarboxylate additive molecules diffuse from a diffuse layer of the concrete mix, fill capillaries in the lubricant film, reduce its viscosity, act as additives that regulate spreading of lubricant and facilitate removal of air bubbles in a surface layer. Experimental studies of the combined effect while using low viscosity grease based on vegetable oils and modifying additives have confirmed the above provisions. The polycarboxylate-based additive has made the greatest impact on reduction of concrete surface porosity and content of all types of pores in the concrete has been approximately at the same level.
Study of Physical and Mechanical Properties of Centrifuged Concrete
Authors: Palevoda I. I. , Zhamoidzik S. M. , Nekhan D. S. , Batan D. S.
Published: August 2019

The paper presents a complex of laboratory and theoretical studies of physical and mechanical properties in centrifuged concrete while using samples of sectoral cross-section which are cut in layers from a finished product. A post made of concrete having B40 grade for compression strength and manufactured while using centrifugation with the help of РТЦ-5 machine. Assessment of heterogeneity across section thickness has been carried out by visual determination of composition changes in cross section, determination of strength, density of the obtained concrete samples, and water content over cross section of concrete mix. According to the results of a visual study on composition of a concrete structure it has been revealed that 1/8 part of the structure (from an inner surface) does not have a large aggregate. Later, as it moves to periphery, there is an increase in coarse aggregate and a decrease in size and number of cells between grains of gravel. An analysis of experimental data has shown that properties of the centrifuged concrete in samples being sawn in layers change significantly: density of concrete in samples of an inner layer is lower by 8 % than in samples of an outer layer, and compressive strength of concrete – by 34 %, water content of concrete mixture of samples of the inner layer has turned out to be by 43 % higher than in samples of the outer layer. Approximating curves showing regularities of changes in density, concrete strength, water content of concrete mixture over thickness have been constructed in the paper. Linear and exponential equations have been obtained that describe changes in physical and mechanical properties of centrifuged concrete over section depending on structure properties as a whole, which, taking into account the obtained correction factors k1 and k2, can be used with an acceptable level of confidence in practical calculations of centrifuged concrete structures. Relationship between strength of centrifuged concrete varying over cross section and action of a centrifugal force of inertia has been revealed in the paper. An equation has been obtained that relates the strength of centrifuged concrete to its density. Analysis of the research results makes it possible to assert that the main source of loading perception in centrifuged concrete structures is outer layers.
Influence of Polyfunctional Additive on Hardening Process and Properties of Cement Concrete
Authors: Gurinenko N. S. , Batyanovskiy E. I.
Published: August 2019

The paper presents results of research aimed at developing a new semi-functional concrete additive that provides an increase in rate and level of its strength growth while reducing energy costs to accelerate hardening process, as a basis for reducing energy intensity in manufacturing of concrete and reinforced concrete products and structures. Experimentally a rational ratio of components for a polyfunctional additive has been found of mass cement: a superplasticizer based on polycarboxylate resins (for example, “Stachement 2000” or “Relamiks PC”) – 0.5 %, ultradispersed microsilica (SiO2) – 1.0 %, sodium sulfate (Na2SO4), hardening accelerator – 0.5 %, aluminum sulfate (Al2(SO4)3), sealing additive structure ‒ 0.25 %. The mentioned components ensure the largest increase in strength of cement stone and structural heavy concrete. Results of derivatographic and X-ray phase analyses have shown that strength growth is based on formation of a fine-crystalline form of low-base crystalline silicates of CSH-silicate group, which complements traditionally formed C2SH by the reaction of threeand two-calcium silicate cement with water, as well as it is based on an increase in the number of neoplasms due to the reaction of Ca(OH)2 with amorphous SiO2 and ettringite 3CaO × Al2O3 × 3CaSO4 × 32H2O, being formed due to reactions with cement aluminates these are accelerating-compacting additive components, that in total provides an increase in density and strength of cement stone. While having the case with concrete, the effect is complemented by hardening the zone of contact between aggregate surface and cement stone due to the reaction between Ca(OH)2 and SiO2. These effects have been confirmed by growth (up to 38 %) of water which is chemically bound with cement in presence of a multifunctional additive in samples of cement stone, which is characterized by the largest strength. While using standardized testing methods, effectiveness of a multifunctional additive has been experimentally confirmed and it has been expressed in growth of quality characteristics and properties of structural heavy concrete: compressive strength – up to 40–60 %, flexural strength – up to 15 %, reduction of shrinkage – up to 50 % and water absorption – by 1.5–2 times, increase in frost resistance from brand F250 to F500, water resistance – from W6–W8 to W20.
Memories of the Ebola Virus Disease outbreak affect decisions regarding health care service utilization in Guéckédou district (epicentre) in Guinea: A cross-sectional study of children with febrile illness
Authors: CAMARA Bienvenu Salim , Okumura Junko , Delamou Alexandre
Published: August 2019

Background

The 2013–2015 Ebola Virus Disease (EVD) outbreak in Guinea resulted in community mistrust that influenced health care service utilization. This study aimed to assess whether EVD-related memories affect post-outbreak health-seeking behaviours for children under five years of age with febrile illnesses in Guéckédou district, Guinea.

Methods

This cross-sectional study was conducted by interviewing caregivers of children under five years of age in the sub-district most affected by the EVD outbreak (Guèndembou) and the least affected sub-district (Bolodou) in Guéckédou district. Memories of the outbreak were referred to as EVD-related fears in the post-EVD period, which was based on a series of questions regarding current feelings.

Results

While the majority of caregivers sought care for their children with febrile illness in both districts, a statistically significantly higher proportion of caregivers in Guèndembou sought care, compared to caregivers in Bolodou. Though not statistically significant, caregivers with a fear score above the median and those who reported the death of family members or friends due to EVD were more likely to seek care.

Conclusions

This study found that the presence of EVD memories is likely to have a positive influence on health-seeking behaviour in the rural district of Guéckédou. However, the findings call for more efforts to preserve communities’ key values and address the psychosocial effects of EVD in rural Guinea.
Bisphenol A Toxicity: Familiarity, Knowledge, Attitude, and Practice Among University Students in Lebanon
Authors: Assi Lama , Labban Muhieddine , El-Dana Fouad , Hasbani Divina Justina , Moujaes Lea , Al-Gibbawi Mounir , Makki Maha , Tamim Hani
Published: August 2019

Background: In the absence of strict regulations, the extent of exposure to Bisphenol A (BPA) toxicity depends mainly on the consumers’ own knowledge, attitude, and practices about the matter. The aim of this study was to assess the current level of familiarity and knowledge about BPA, attitude towards it, practices related to the use of BPA-containing products, and the predictors of each.
Methods : We carried out a cross-sectional study among students at the American University of Beirut, Lebanon, between January and April 2017. Full-time students above the age of 18 and registered in a specific major were eligible to participate in the study. An English questionnaire that assesses familiarity, as well as knowledge, attitude, and practice (KAP) was developed based on current literature and expert opinion. Demographics, lifestyle, and level of familiarity with the topic were assessed among all participants. Predictors of familiarity, defined as knowing at least a little about BPA, were assessed among all participants using bivariate and multivariate analyses. Among students familiar with BPA, predictors of higher KAP scores were assessed by similar analyses. Adjusted odds ratios (OR) with 95% confidence interval (CI) were reported.
Results : The level of familiarity with BPA was 23.7%. Studying in a health-related field was a predictor of familiarity (adjusted OR=3.11; CI: 2.08-4.66). Among those familiar with BPA, a higher study level predicted better knowledge (adjusted OR=3.03; CI: 1.33-6.89) and better practices to avoid BPA (adjusted OR=2.53; CI: 1.08-5.97). Additionally, a higher family income was a predictor of higher knowledge and better practice, with an adjusted OR of 2.82 (CI: 1.12-7.08), and 2.9 (CI: 0.99-8.56), respectively. Father education was also a predictor of safer practices with an adjusted OR of 2.58 (CI: 1.01-6.56). Furthermore, female gender was the only predictor of higher attitudes towards BPA and its potential health effect (adjusted OR=2.19; CI: 1.08-4.46).
Conclusion : Familiarity with BPA among university students in Lebanon is low. Future research is needed to determine the level of familiarity, knowledge, attitude, and practice among the general Lebanese population. Awareness campaigns and policy change are needed to ensure lower exposure to BPA.
Association between Smoking and Academic Performance among Under-Graduate Students of Pakistan, A Cross-Sectional Study
Authors: Ullah Sana , Sikander Siham , Abbasi Mudassar Mushtaq Jawad , Rahim Syed Aftab , Hayat Babar , Haq Zaeem Ul , Ahmad Iftikhar
Published: August 2019

Background

Prevalence of smoking is on the rise and its harmful effects on every organ of body are well known. Smoking is a growing concern due to adverse effects on health, its association with academic performance is not well studied.

Objectives

This study aims to assess the prevalence of smoking among undergraduate students of age 18-24 years in a public sector university of Islamabad, association between smoking and academic performance and also to assess the reasons of smoking initiation among undergraduate students.

Methods

The study included 500 undergraduate students. A self-report structured questionnaire was used to assess smoking, dietary habits, physical activity, parent’s smoking, friend’s smoking, time spent on mobile and TV and academic performance for collection of data. Logistic regression was used for association between smoking and academic performance.

Results

Results of study show that 112/500 (22.4%) students were smokers among them 93/112 (34.6%) were males and 19/112 (8.2%) were females. The mean age of study participants was 21.50 years (SD: 1.72. Prevalence of smoking was higher in students belonging to rural areas 23.5% to that of urban areas 21.9%. Three major reasons of smoking initiation; 25% students stated peers and friends, 21% stated easy availability while 14% said it was fun and enjoyment they started smoking. High academic performance was found to be inversely proportional to student’s smoking; at p-value 0.000 smokers had 2.5 (1.77, 3.74) odds of lower academic performance, boys having 2.17 (1.56, 3.03) odds of lower academic performance in last semester exams.

Conclusion

Findings highlighted extensive cigarette smoking among undergraduate students of Islamabad. Smoking is significantly and negatively associated with academic performance.
Autophagy attenuates postoperative cognitive dysfunction by up-regulating cystatin C in aged rats undergoing splenectomy
Authors: Xing-hua Bi , Long-yuan Zhou , Chang Cai , Yong Qi , Li Yan
Published: August 2019

Background: This study aimed to explore whether autophagy can attenuate postoperative cognitive dysfunction (POCD) by up-regulating cystatin C in aged rats undergoing splenectomy.
Methods: Rats were randomized into four groups (n = 10 per group): normal control (CON), surgery (SUR), surgery + rapamycin (autophagy inducer) at 1.0 mg/kg/d (RAP), and surgery + 3-methyladenine (autophagy inhibitor) at 3.0 mg/kg/d (3-MA). Treatments were carried out for four weeks. Learning and memory were assessed postoperatively using the Morris water maze. Hippocampal expression of the autophagy-related proteins ATG5, LC-3B, Beclin1, and p62 as well as Cys C was assayed using Western blotting and real-time polymerase chain reaction.
Results: SUR animals showed higher levels of autophagy and higher expression of autophagy proteins and Cys C than CON animals. These levels were even higher in RAP animals, which also showed lower levels of the inflammatory cytokines IL-1β, IL-6 and TNF-α than the other groups. Learning and memory functions were higher in RAP animals than in the other groups on days 5 and 7. Effects of 3-MA were opposite to those of RAP.
Conclusion: Autophagy improves learning and memory in aged rats following splenectomy, which may involve up-regulation of Cys C and attenuation of neuroinflammation.
The correlation of JKAP with risk, severity, inflammation and in-hospital mortality of severe acute pancreatitis
Authors: Li Jing , Ming Min , Han Yonghong
Published: August 2019

Background

This study aimed to investigate the predictive value of JNK pathway-associated phosphatase (JKAP) level for severe acute pancreatitis (SAP) risk, and its association with disease severity, inflammation and in-hospital mortality in SAP patients.

Methods

Our study recruited 50 SAP patients, 50 moderate-severe acute pancreatitis (MSAP) patients, 50 mild acute pancreatitis (MAP) patients and 50 healthy controls. And the serum samples were obtained from all acute pancreatitis patients within 24 hours after admission and from health controls at their enrollment to detect JKAP level by enzyme-linked immunosorbent assay.

Results

JKAP level was decreased in SAP patients compared with healthy controls, MSAP and MAP patients. And receiver operating characteristics (ROC) curve analysis revealed that JKAP could not only distinguish SAP patients from healthy controls (AUC: 0.914, 95%CI: 0.857-0.971), but also differentiate SAP patients from MAP patients (AUC: 0.869, 95%CI: 0.802-0.937) and MSAP patients (AUC: 0.712, 95%CI: 0.610-0.813). In SAP patients, JKAP was negatively correlated with Ranson score, acute physiology and chronic health care evaluation II (APACEH II) score, sequential organ failure assessment (SOFA) score and C-reactive protein (CRP). And lower JKAP level, higher CRP level, Ranson score, APACEH II score and SOFA score were associated with increased in-hospital mortality in SAP patients. Additionally, ROC curve analysis showed that JKAP could predict decreased in-hospital mortality in SAP patients (AUC: 0.720, 95%CI: 0.526-0.914).

Conclusions

JKAP might serve as a biomarker for disease risk and management for SAP.
Acne and psychiatric comorbidities in Lomé (Togo): case-control study
Authors: SAKA Bayaki , TECLESSOU Julienne , AKAKPO Abla Sefako , MOUHARI-TOURE Abas , KASSANG Panawè , MAHAMADOU Garba , GNOSSIKE Piham , AKAOLO Tchaa , Ahloma Lidawouwè , KOMBATE Koussake , PITCHE Palokinam
Published: August 2019

Objectif The aim of this study was to investigate psychiatric comorbidities (depression and anxiety) associated with acne in dermatology in Lomé (Togo). Material and methods We conducted a case-control study between July 2017 and February 2018. Each case was matched to two controls by sex and age (± 5 years). The ECLA grid was used for the clinical evaluation of acne, and the GAD-7 and PHQ-9 questionnaires were used for respective screening of anxiety and depression. Results We recruited, with their consent, 900 subjects including 300 patients and 600 matched to two controls according to sex and age (± 5 years). The mean age of the cases was 23.7±5.7 years and that of the controls was 23.6 ± 6.2 years, with no difference between the two groups (p = 0.9362). The overall severity score for acne according to the ECLA grid ranged from 2 to 28 points. The severity of acne was not correlated with anxiety scores (GAD-7: r = -0.02; p = 0.6724) and depression (PHQ-9: r = 0.11; p = 0.0567). The GAD-7 questionnaire allowed us to note 72 cases of anxiety (24%) among our patients and 37 cases among our controls (6.2%). The mean GAD-7 score in the cases was 6.5±4.9 compared with 2.9±3.8 in the controls (p <0.0001). Similarly, the PHQ-9 questionnaire allowed us to detect 92 cases of depression (30.7%) among our patients and 82 cases of depression among our controls (13.7%). The average of the PHQ 9 score in the cases was 7.2 ± 5.2 versus 4.0 ± 4.7 in the controls (p <0.0001). Conclusion: Depression and anxiety are significantly associated with acne, regardless of severity. It is important to look for them in any patient admitted for acne, for a psychological / psychiatric decision.
Expression of MMP28 in bladder cancer tissue microarray and its clinical significance
Authors: Heng Wang , Junxiu Wu , Xinpeng Chen , Qi Zhang , Tingxiao Zhao , Dahong Zhang
Published: August 2019

Background: The aim of this study was to explore the expression pattern and prognostic value of MMP-28 for bladder cancer and analyze its relationship with the clinicopathological features of human bladder cancer.
Methods: Immunohistochemical staining for MMP28 was performed in 491 archived radical bladder cancer resection and 80 normal specimens. The immunoreactivity of these proteins was correlated to evaluate their clinical significance as prognostic factors.
Results: Protein level of MMP-28 was up-regulated in bladder cancer compared with adjacent non-tumor tissues. The increased expression of MMP-28 was significantly associated with high histological grade, lymph node metastasis, lymphatic invasion and distant metastasis (P<0.05). High expression of MMP-28 was also associated with greater risk of disease progression and decreased chance of cancer-specific survival. Further analysis suggested that MMP-28 was related with decreased overall survival.
Conclusions: MMP-28 could be used as an effective marker for tumor diagnosis and predict tumor progression in bladder cancer. The expression patterns of MMP-28 interaction correlated well with the pathological stage, disease progression and tumor-specific survival. The finding may help identify more biologically aggressive carcinomas which could aid in patients who benefit from more intensive adjuvant therapy.
Bcl-2 and Ki67 expression in endometrial polyps in postmenopausal women and their association with obesity
Authors: Giordano Mario Vicente , Lucas Hiram da Silveira , Fiorelli Rossano Kepler Alvim , Giordano Luiz Augusto , Gáspare Mario , Júnior José Maria Soares
Published: August 2019

Background: Obesity is a global problem and is associated with numerous diseases, including endometrial disorders in postmenopausal women, such as adenocarcinoma, hyperplasias and endometrial polyps, and with risk of malignant transformation of these structures. We aimed to evaluate the influence of body mass index (BMI) on the cell proliferation markers (Bcl-2 and Ki67) on the endometrial polyps in postmenopause women. Methods: Prospective cross-sectional study using immunohistochemical analysis of the expression of the cell proliferation marker (Ki67) and an anti-apoptotic gene (Bcl-2) in endometrial polyps, in postmenopausal women. The polyps were identified by hysteroscopy and all were removed. The patients were divided into two groups related to BMI: a) BMI <29.9 kg/m2 (normal weight); b) BMI >30 kg/m2 (obese). We analysed the expression of these markers in relation to polyp size, histological type and time since menopause. The interpretation of the Ki67 and Bcl-2 expression data in the endometrial polyps accounted for the percentage of positive cells: score 1 (mild: less than 5% of cells showed expression); score 2 (moderate: between 5 and 50% of cells showed expression); score 3 (severe: more than 50% of cells showed expression). Statistical analysis was performed using the SPSS Statistics program for Windows v23, and the non-parametric Mann-Whitney test was used to analyse the Bcl-2 and Ki67 expression in the glandular and stromal components of the polyps. A significance level of p<0.05 was adopted for rejecting the null hypothesis. Results: There was greater glandular expression of Ki67 in hyperplastic polyps (p=0.04) and greater expression of Bcl-2 in the stroma of polyps larger than 2 cm (p=0.04). No difference in the Ki67 and Bcl-2 expression was found in the glands and stroma of the polyps when compared obese and non-obese postmenopause patients. Conclusion: Our findings suggest that the BMI may not have influence on the proliferation markers (Ki67 and Bcl-2) in the polyps of postmenopausal women.
Appropriate Complementary Feeding Practice and associated factors among mothers with children age 6- 23 months in Faggeta-Lekoma District, Northwest Ethiopia: community- based cross - sectional study
Authors: Ferede Addisu Belete , Bikes Gashaw Andargie , Gebremichael Tsgehana GebreGyorgis
Published: August 2019

Abstract
Objective: the aim of the study was to assess appropriate complementary feeding practices and associated factors among mothers with children of age 6 - 23 months in Faggeta-Lekoma District, Northwest Ethiopia.
Result – A total of 593 study subjects were included in the study. The magnitude of appropriate complementary feeding practice was 10.6%. Majority (67.1%) of the mothers timely initiated complementary feeding at 6 months. About 60% of mothers fulfill the minimum meal frequency feeding to their children, the day preceding the survey. Only 12.3 % mothers offered four or more food groups to their child Mother’s education: high school and above [AOR=3.12(95%CI 1.43, 6.81)], postnatal care visit [AOR=5.30 (95%CI 2.69, 10.42)], Age of a child: 18-23 months [AOR=3.98 (95%CI 1.55, 10.22)] were significantly associated with appropriate complementary feeding practice.
Keywords: appropriate Complementary feeding practice, Children aged 6–23 months, Ethiopia
Skin transcriptome reveals the Periodic changes in genes underlying hair follicle cycling in Cashmere goats
Authors: Liu Zhihong , Yang Feng , Zhao Meng , Mu Qing , Che Tianyu , Xie Yuchun , Ma Lina , Mi Lu , Li Jinquan , Zhao hong Yan
Published: August 2019

Background
Cashmere goats, as an important part of animal husbandry production, make outstanding contributions to animal fiber industry. In recent years, a great deal of research has been done on the molecular regulation mechanism of hair follicle cycle growth. However, there are few reports on the molecular regulation mechanisms of secondary hair follicle growth cycle in cashmere goats. In order to explore the changing regularity of wool follicle cycle and the role of key genes in wool follicle cycle of cashmere goats. we used transcriptome sequencing technique to sequence the skin of Inner Mongolia cashmere goats in different periods, Analyze the variation and difference of genes in the whole hair follicle cycle. And then, we verified the regulation mechanism of cashmere goat secondary hair follicle growth cycle by fluorescence quantitative PCR.

Results

As the result shows: growth period (March-September), regression period (September-December) and resting period (December-March). The results of differential gene analysis showed that March was considered the beginning of the cycle, and the difference of gene expression was the most significant. Cluster analysis of gene expression in the whole growth cycle further supported the key nodes of the three periods of villus growth, and the differential gene expression of keratin corresponding to the villus growth cycle further supported the results of tissue slices. Quantitative fluorescence analysis showed that KAP3-1, KRTAP 8-1 and KRTAP 24-1 genes had close positive correlation with the growth cycle of cashmere, and their regulation was consistent with the growth cycle of cashmere. However, there was a sequence of expression time, indicating that the results of cycle regulation made the growth of cashmere change.

Conclusion

The growth cycle of cashmere hair could be divided into three distinct periods: growth period (March-September), regression period (September-December) and resting period (December-March).March was considered the beginning of the cycle, KAP and KRTAP had close positive correlation with the growth cycle of cashmere, and their regulation was consistent with the growth cycle of cashmere. However, there was a sequence of expression time, indicating that the results of cycle regulation made the growth of cashmere change.
Adaptive evolution of low salinity tolerance and hypoosmotic regulation in a euryhaline teleost, Takifugu obscurus
Authors: Zhang Hanyuan , Hou Jilun , Liu Haijin , Zhu Haoyong , Xu Gangchun , Xu Jian
Published: August 2019

Background: The mechanism of osmoregulation is crucial for maintaining growth, development, and life activities in teleosts. Takifugu obscurus, the only euryhaline species in the genus Takifugu, is a proper model organism for studying the mechanism of low salt-tolerance and hypoosmotic regulation.
Results: In this study, whole genome sequencing data were obtained from 90 pufferfish representing five species within this genus, T. rubripes, T. obscurus, T. flavidus, T. niphobles, and T. bimaculatus. Using a phylogeny, PCA, and population structure analyses, we observed similar amounts of population genetic differentiation among species. The five species are closely related to each other and have differentiated within a relatively short period, while T. bimaculatus and T. flavidus shared the most similar genetic backgrounds. We further identified hundreds of genes under selection related to hypoosmotic regulation between T. obscurus and other Takifugu species, including 16 representative genes involving ion transporters (atp1a3, atp2a2, atp2a3, slc13a1, slc5a8, slc12a2, slc12a4, slc26a2, scn1b, and kcna2/3/10), genes involved in hormone regulation (fyn, prlr, and grb2), and a gene associated with water absorption (aqp3). Conclusions: Our findings provide preliminary insight into the mechanism of osmoregulation and will facilitate follow-up validation of candidate genes related to osmoregulation in T. obscurus.
Ability of Real-time PCR in diagnose Differentiation Various Forms of Cutaneous Leishmaniasis: A Comparative Study with Histopathology
Authors: Abadi Maryam Fekri Soofi , Fekri Meisam , moradabadi alireza , Vahidi Reza , Meymandi Simin Shamsi , Dabiri Donya , dabiri shahriar
Published: August 2019

objective: Histopathological studies suggest that parasite load is different between acute and chronic forms of cutaneous leishmaniasis (CL). However, highly sensitive detection methods are still needed to distinguish different forms of leishmaniasis. In the present study, we developed a quantitative real-time polymerase chain reaction (PCR) to detect and quantify leishmania tropica parasites in paraffin-embedded tissue samples.
Results: The ability of real-time PCR for leishmania detection was higher than histopathological evaluation. The parasite loads were quantified by qPCR assay and microscopic evaluation were highly correlated ( r =0.598; P <0.001). Among patients, the parasite load was inversely correlated with disease duration (acute CL lesions had very higher parasite loads than chronic CL lesions), but there was no difference in parasite load according to the patients’ age and sex as well as location of the lesions. In contrast to Ridley scoring system (P<0.001), there were no statistically significant differences in the relative number of parasites among the lupoid and non-lupoid forms of chronic lesions in real-time PCR (P=0.549), which indicates the superiority of histopathological evaluation in CL forms differentiation.
FACTORS DETERMINING THE QUALITY MANAGEMENT OF HIGHER EDUCATION: A CASE STUDY AT A BUSINESS SCHOOL IN INDONESIA
Authors: Simangunsong Eliot
Published: August 2019

Despite the facts that higher education institutions are the source of quality concept and theory, they have been lagging behind manufacturing or service businesses in embracing and carrying out proper quality management. Managing quality in higher education is a difficult task due to several factors such as different perspectives between stakeholders and traditional characteristics of institutions. On the other hand, accreditation, for example by the Indonesian Bureau of Higher Education Accreditation, and international accreditation bodies, such as AACSB, EQUIS, is perceived as a tool to demonstrate a certain quality threshold.  However, many studies argue that periodic quality assessments using recognized accreditation bodies do not touch inherent quality issues in education, and that they are generally used as an exercise of quality control. The objective of this study is to look beyond quality assessments using these recognized accreditation bodies and examine dimensions of quality from university's stakeholder’s point of view, especially the stakeholder that represents the demand side. Factor analysis is conducted, and the number of factors proposed by the results are identified. There are seven quality dimensions that have impacts on the quality management system in higher education. Three dimensions are new findings, i.e., the importance of providing health and insurance, the importance of good ambiance of campus environment, and stakeholder’s explicit ability to demonstrate quality in higher education.
THE EFFECTIVENESS OF MULTICULTURAL APPROACH IN WRITING ACHIEVEMENT OF INDONESIAN LANGUAGE AMONG ISLAMIC ELEMENTARY SCHOOL STUDENTS
Authors: Alfulaila Noor , Haryadi Haryadi , Sudrajat Ajat , Nashrullah Nashrullah
Published: August 2019

Multicultural approach in Indonesian language has become an absolute necessity over the last years. This research highlights the role of multicultural culture as a means to improve writing achievement of Indonesian Language among elementary school students. This study aims at determining the effectiveness of the multicultural approach in the writing achievement of Indonesian language among fifth grade students of islamic elementary school who are grouped based on their learning motivation. This study can be catagorized as an experimental study with 2x2 factorial design. The independent variable consists of two categories, multicultural and conventional approaches. The population was  60 fifth grade students of at two private islamic schools. The data was collected using learning achievement tests and learning motivation questionnaires, and analyzed using two-way ANOVA and sheffe test. The results showed that (1) there were a gap in learning achievement between students in the experimental group and control group students; (2) there were differences in learning achievement between students with high motivation between both groups; (3) there were differences in learning achievement between low motivated students between both groups; (4) the multicultural approaches proved to be more effective than the conventional one; and (5) there was no interaction between the approaches and the learning motivation.
A CHARACTER-BASED ASSESSMENT MODEL FOR VOCATIONAL HIGH SCHOOLS
Authors: Supriyadi Edy , Zamtinah Zamtinah , Soenarto Sunaryo , Hatmojo Yuwono Indro
Published: August 2019

The competencies of vocational high school (VHS) graduates, especially in terms of character have not met its standards. This study aims to develop a character-based assessment model for VHS in the form of a guide and procedure. Borg & Gall’s (1989) model with the following stages was utilized: (1) needs analysis, (2) planning, (3) development, (4) phase I trial, (5) phase II trial, (6) evaluation of model effectiveness, and (7) final product development. This study involved some experts in the model validation. Trials were done to teachers and principals in eight VHSs in Yogyakarta Special Province, Indonesia in 2017 (first trial), and those from 42 VHSs throughout Java island, Indonesia in 2018 (second trial). Data were collected by questionnaires and interviews and analysed by quantitative and qualitative descriptive statistics. This study suggest that, overall, the model is appropriate and feasible to use, proven by (1) the assessment guide is categorized as ‘very appropriate’ (Mean 3.55; SD .52); (2) assessment procedure achieves an ‘very appropriate’ category (Mean = 3.60; SD = .51); and (3) effectiveness of the assessment model in trial 1 is in the ‘very appropriate’ category (Mean 3.43, and SD .51), and in trial 2 is in the ‘appropriate’ category (Mean 3.38, SD .53).
TEACHING-LOVING-CARING (ASAH-ASIH-ASUH) AND SEMI-MILITARY EDUCATION ON CHARACTER EDUCATION MANAGEMENT
Authors: Sukendar Asep , Usman Husaini , Jabar Cepi Safrudidin Abdul
Published: August 2019

Character education for students is important for their future because personal character traits determine the quality of human life. This qualitative study aims to analyze the planning and implementation of character education at Taruna Nusantara Senior High School (SHS), Magelang - a boarding senior high school that combines teaching-loving-caring (asah-asih-asuh) and semi-military education. The unit of analysis consists of individuals and group of subjects directly or indirectly involved in the education process at the researched school and the surrounding, as well as the artifacts. The data are collected through interview, observation, and documentation, and  are subsequently analyzed using Huberman and Saldana’s interactive model. The results indicate that, in the planning, the school put more emphasis on three characteristics in character education that characterizes the school:  religiosity, morality and leadership. The planning of character education is participatory and integrated. It is implemented in and around the boarding school learning environment. The activities include teaching, training, parenting, and student development.