bluuebunny/crossref_metadata_2025 huggingface dataset:
Does maturity status explain training intensity and physical fitness variations of youth football players?
Authors: Silva Rui , Clemente Filipe Manuel , González-Fernández Francisco , Nobari Hadi , Haghighi Hamed , Carral José María Cancela
Published: May 2022

Background: Different predictive maturity status methods are available for coaches to apply during the training process. However, understanding the potential use of such methods to explain both physical fitness and training intensity (TI) measures, can give coaches new insights to better adjust training according to each individual needs. Objectives: The purpose of the present study was two-fold: (1) To analyse TI and physical fitness variations of youth football players after a full-season; and (2) to examine whether training intensity and physical fitness variations are explainable by estimated maturation status.Methods: Twenty-seven youth elite Under-15 football players were daily monitored for TI measures during 38 weeks. At the beginning and at the end of the season, all players were assessed for physical fitness. Also, different methods of maturity status estimation were collected at the beginning of the season.Results: Significant differences were found for all physical fitness and TI measures after the season. The 2-digit (2D) and 4-digit (4D) of left and right hands had negative moderate correlations with change of direction (COD) variations (r=-.39 to -.45 | p=.05 to .02). The right-fingers 2D:4D (RF2D:4D) had positive moderate-to-large correlations with all TI measures (r=-.40 to -.56 | p=.04 to .001). From the reported significant correlations, the RF2D:4D measure explained the greatest proportion of all TI variations (r=.40 to .62 | p=.04 to .001).Results: The use of the 2D:4D method of maturity status estimation may be a potential predictor of TI variations. Furthermore, the maturity offset and 2D:4D methods may not be useful to predict physical fitness variations after an Under-15 football season.
Association between Post-acute Sequelae of SARS-CoV-2 and Physical Inactivity: A Cohort Study of 614 COVID-19 survivors
Authors: Gil Saulo , Gualano Bruno , Araújo Adriana Ladeira , Júnior Gersiel Nascimento Oliveira , Damiano Rodolfo Furlan , Pinna Fabio , Imamura Marta , Rocha Vanderson , Kallas Esper , Batistella Linamara Rizzo , Forlenza Orestes V. , Carvalho Carlos R.R. , Busatto Geraldo Filho , Roschel Hamilton
Published: May 2022

The aim of this study was to determine whether Post-acute Sequelae of SARS-CoV-2 Infection (PASC) are associated with physical inactivity in COVID-19 survivors. This is a cohort study of COVID-19 survivors discharged from a tertiary hospital in Sao Paulo, Brazil. Patients admitted as inpatients due to laboratory-confirmed COVID-19 between March and August 2020 were consecutively invited for a follow-up in-person visit 6 to 11 months after hospitalization. Ten symptoms of PASC were assessed using standardized scales. Physical activity was assessed by questionnaire and participants were classified according to WHO Guidelines. 614 patients were analyzed (age: 56±13 years; 53% male). Frequency of physical inactivity in patients exhibiting none, at least 1, 1 to 4, and 5 or more symptoms of PASC was 51%, 62%, 58%, and 71%, respectively. Adjusted models showed that patients with one or more persistent PASC symptoms have greater odds of being physically inactive than those without any persistent symptoms (OR: 1.56[95%CI: 1.03 to 2.37], P=0.034). Dyspnea (OR: 2.22[1.50 to 3.33]), fatigue (OR: 1.96[0.43 to 0.95]), insomnia (OR: 1.59[1.10 to 2.31]), post-traumatic stress (OR: 1.53[1.06 to 2.23]), and severe muscle/joint pain (OR: 1.49[95%CI: 1.05 to 2.00]) were associated with greater odds of being physically inactive (all P<0.05). This study suggests that PASC is associated with physical inactivity, which itself may be considered as a persistent symptom among COVID-19 survivors. This may help in the early identification of patients who could benefit from interventions tailored to combat inactivity, with potential beneficial impacts on overall morbidity/mortality and health systems worldwide.
Light-matter-interaction beyond Born-Oppenheimer approximation mediated by stimulated phonon polaritons
Authors: Lu Yao , Wu Qiang , Xiong Hao , Zhou Xu , Li Zhixuan , Qi Jiwei , Xu Xitan , Ma Ruobin , Fan Jiang , Chen Zhigang , Xu Jingjun
Published: May 2022

For decades, the light-matter interaction (LMI) mechanism based on Born-Oppenheimer (BO) approximation has dominated the fields of photonics, materials, and condensed-matter physics. However, in polar crystals, the BO approximation is not applicable when stimulated phonon polaritons (SPhPs) are excited. Unlike the studies on topological physics and physical chemistry that beyond BO approximation, here we unravel an SPhP-mediated LMI (SPhP-LMI) mechanism in polar crystals, which is radically different from the traditional LMI interpreted by BO approximation. In the regime of SPhP-LMI, two exemplary experiments were conducted at different wavelengths: Q-factor increase of a lithium niobate (LiNbO3) terahertz microcavity, and a five orders-of-magnitude enhancement of second-harmonic generation of infrared laser pulses in an LiNbO3 slab. Our study brings about a new fundamental understanding of the LMI mechanism and shows great potential in the fields of optics/photonics and condensed-matter physics.
Impairment of host adaptive immune response to Candida albicans infection: an in-silico insight on SARS-CoV-2 conspiracy
Authors: KABIR ALI , Das Deepyaman , Podder Soumita
Published: May 2022

Recent evidence reported that SARS-CoV-2 infections might trigger serious consequences in otherwise asymptomatic Candida albicans infections. To elucidate the mechanism of such co-infections, we have reconstructed Protein-protein interaction network (PPINres)with the upregulated genes in blood of C. albicans infected asymptomatic patients and identified 55 Core Genes (CGs). Functional enrichment of CGs evidenced their potential to resist fungal infection. With CGs, Gene Regulatory Network (GRNres) was reconstructed with TF-TF, TF-CG, CG-CG interactions and it exhibited 7 Articulation Points (APs). Mapping these TF-CG interactions with DEGs of COVID-19 revealed that 460 TF-CG pairs and 4 APs are downregulated. Subsequently, functional and pathway enrichment analysis of these gene pairs was performed. Our overall results suggest that weakening of adaptive immune response might pave the path for C. albicans superinfections in COVID-19 patients.
Surface quality study of AZ31B Mg alloy in electric pulse-ultrasonic assisted incremental sheet forming
Authors: Song Zimo , Zhang Haoran , Chu Xingrong , Zhao Zhiyong , Gao Jun
Published: May 2022

Poor surface quality is one of the main problems for the forming and application of magnesium alloys. In this study, electric pulse and ultrasonic vibration were simultaneously applied to the incremental sheet forming (ISF) process of magnesium alloys, and the effect of electric pulse - ultrasonic composite energy field on the surface quality was investigated. Compared with electric pulse assisted forming, composite energy field could improve the surface quality at the condition of higher current frequency (≥ 350HZ), lower step depth (0.1mm) and keep the effective current density less than 30A/mm2. Moreover, although the surface quality can be improved by ultrasonic energy in both directions, the effect is more significantly in direction perpendicular to the feed direction than that in the direction parallel to the feed direction. The repeated rolling caused by ultrasonic vibration is benefit to the rearrangement of the surface gully, and makes the surface profile height distribution relatively uniform. The surface quality also would be aggravated due to the “jumping” effect of the tool head and serious surface oxidative, which caused by excessive temperature increasing at the condition of very current density.
Postoperative Feeding In Neonatal Duodenal Obstruction
Authors: Aroonsaeng Dolrudee , Losty Paul D , Thanachatchairattana Pornsri
Published: May 2022

Background
Findings from manometry studies and contrast imaging reveal functioning gastric physiology in newborns with duodenal atresia and stenosis. Stomach reservoir function should therefore be valuable in aiding the postoperative phase of gastric feeding. The aim of this study was therefore to compare the feasibility of initiating oral or large volume(s) gavage feeds vs small volume bolus feeds following the operation for congenital duodenal anomalies.
Methods
Single-center electronic medical records of all babies with duodenal atresia and stenosis admitted to a university surgical center during January 1997 - September 2021 were analyzed. A fast-fed group (FF) included newborns fed with oral or gavage feeds advanced at a rate of at least 2.5 ml/kg and then progressed more than once a day vs slow-fed group (SF) fed with gavage feeds at incremental rate less than 2.5 ml/kg/day for each time period of oral tolerance or by drip feeds. Total feed volume was limited to 120–150 ml/kg/day in the respective study cohort populations.
Results
51 eligible patients were recruited in the study - twenty-six in FF group and twenty-five in SF group. Statistically significant differences were observed in the ( i ) date of first oral feeds (POD 7.7 ± 3.2 vs 16.1 ± 7.7: p < 0.001) and ( ii ) first full feeds (POD 12.5 ± 5.3 vs 18.8 ± 9.7: p < 0.01) in FF vs SF study groups.
Conclusion
Initial feeding schedules with oral or incremental gavage-fed rates of at least 2.5 ml/kg in stepwise increments and multi-steps per day is wholly feasible in the postoperative feeding regimens of neonates with congenital duodenal disorders. Significant health benefits are thus achievable in these infants allowing an earlier time to acquiring full enteral feeding and their hospital discharge.
Changes in retail food environments around schools over 12 years and associations with overweight and obesity among children and adolescents in Flanders, Belgium
Authors: Smets Vincent , Vandevijvere Stefanie
Published: May 2022

BackgroundChildren have been found to be extra susceptible to the food environment. This research assessed changes in food environments near schools in Flanders between 2008 and 2020 and associations with children’s and adolescents’ weight status. MethodsThe food environment within a 500m and 1000m road network distance to all primary- and secondary schools was mapped using several spatial indicators. A generalized linear modelling approach was used to explore associations between these indicators and weight status of children and adolescents. ResultsFood environments near schools in Flanders were found to be unhealthy in 2020, with a significant increase in fast-food restaurants and convenience stores between 2008 and 2020. Food environments near schools with a higher proportion of children from a poor socio-economic background were found more unhealthy than those near schools with a lower proportion of such children, regardless of the urbanization level. A significant positive association was found between the density of fast food restaurants as well as convenience stores around primary schools and the weight status of children aged <6 years and 6-12 years. The association between the density of fast food restaurants and convenience stores around secondary schools and the weight status of adolescents, aged 13-14 and 15-18 years, was less clear. ConclusionFood environments around schools in Flanders became more unhealthy over time and were associated with children’s weight status.
Mitral paravalvular leak 3D printing from 3D-transesophageal echocardiography – proof of concept and preparation flowchart
Authors: Jędrzejek Marek , Kozłowski Michał , Jadczyk Tomasz , Peszek-Przybyła Ewa , Pysz Piotr , Wojakowski Wojciech , Smolka Grzegorz
Published: May 2022

Paravalvular leaks (PVLs) can be detected in almost 15% of patients after mitral valve prosthesis implantation. This complication can result in congestive heart failure and hemolysis. Despite advancements in non-invasive imaging, percutaneous closure of PVLs is not always successful. Therefore, efforts are made to improve treatment outcomes by using 3D-printed models of defects as pre-procedural support for interventional cardiologists. Retrospectively, 3D-TEE recordings of 8 patients with clinically significant mitral PVLs were analysed. Qlab Software was used to export DICOM images of each PVL channel, including surrounding tissue. Image segmentation was performed in 3D Slicer, a free, open-source software package used for imaging research. Models were printed to actual size with the polyjet Stratasys Objet 30 printer with a transparent, rigid material. Duration of model preparation and printing, as well as total cost were calculated. Mean total time of model preparation was 430,5 ± 196 min. 3D-printing from 3D-TEE is technically feasible. Both shape and location of PVLs are preserved during model preparation and printing. It remains to be tested if 3D-printing would improve outcomes of percutaneous PVL closure.
Analysis of prognostic factors of undifferentiated pleomorphic sarcoma and construction and validation of a prediction nomogram based on SEER database
Authors: Wang Zimao , Liu JinHua , Han Jingjing , Yang Zheng , Wang Qiying
Published: May 2022

Objective:
The purpose of this study was to construct and validate a nomogram for predicting overall survival (OS) in undifferentiated pleomorphic sarcoma (UPS) patients at 3, 5 years after the diagnosis.
Method:
According to the inclusion and exclusion criteria, 1079 patients with UPS were screened from the SEER database and randomly divided into the training cohort (n = 755) and the validation cohort (n = 324). Patient demographic and clinicopathological characteristics were first described, and the correlation between the two groups was compared, using the Kaplan-Meier method and Cox regression analysis to determine independent prognostic factors. Based on the identified independent prognostic factors, a nomogram survival prediction model for OS in UPS patients was established using R language. The nomogram’s performance was then validated using multiple indicators, including the area under the time-dependent receiver operating characteristic curve (AUC), consistency index (C-index), calibration curve, decision-curve analysis (DCA).
Results:
A total of nine factors ,age, tumor location, tumor size, tumor depth, N stage, M stage, tumor grade, surgery and radiotherapy,were included in the nomogram prediction model as independent influence factor. The OS nomogram prediction model in the model group and validation cohort C-index All greater than 0 .75, the AUC was greater than 0.78, and both were higher than the C of the TNM staging system Index and AUC values. Nomogram prediction model and TNM staging system calibration curve with 4 The 5 ° lines were all relatively conforming. Decision curve analysis showed that both the nomogram model and the TNM staging system had clinical net benefits over a wide range of threshold probabilities, and the nomogram had higher clinical net benefits than the TNM staging system as a whole.
Conclusion:
The nomogram survival prediction model can individualize the prediction of 3-year and 5-year OS in patients with UPS, with good discrimination, accuracy and clinical practicability, which can provide a reference for clinicians and patients to make better clinical decisions.
Numerical Analysis onto Thermal Balance Behaviors of Motorized Spindle Unit
Authors: Zhang Yifan , Liu Teng , Gao Weiguo , Zhang Jianjun , Zhang Dawei
Published: May 2022

Generally, the accuracy stability of precision motorized spindle unit is influenced by its structural thermal balance behaviors (power matching degree of spindle structural heat generations - dissipations). For the accurate analysis onto this spindle heat transfer behaviors based on temperature detections, this paper describes a method constructed with the numerical simulation technology and a proposed GA-ELM algorithm. Firstly, heat-fluid-solid coupling FE transient model is established to simulate spindle thermal behaviors, its thermal loads / boundary conditions are initially according to empirical calculations. Secondly, based on spindle temperature detections, these initial values are applied onto thermal simulations and corrected by GA, to make simulated spindle temperatures gradually approach detections. Specially, ELM is adopted to estimate the functional relationships from parent population to child population generated by genetic operators with the increasing fitness values, and the trained ELM model is utilized to ensure the GA faster convergence. Eventually, based on the corrected thermal load / boundary condition values and simulation results, the time-varying power matching conditions of spindle structural heat generation - dissipation are analyzed. This study provides a theoretical basis for the optimization and promotion of spindle structural design and coolant control strategy.
A genome-wide association study implicates the pleiotropic effect of NMUR2 on asthma and COPD
Authors: Do Ah Ra , An Jin , Jo Jinyeon , Kim Woo Jin , Kang Hae Yeon , Lee Sanghun , Yoon Dankyu , Cho You Sook , Adcock Ian M , Chung Kian Fan , Won Sungho , Kim Tae-Bum
Published: May 2022

Asthma and chronic obstructive pulmonary disease (COPD) are two distinct diseases that are associated with chronic inflammation. They share common features in terms of their advanced stages and genetic factors. The main aim of this study was to identify single nucleotide polymorphisms (SNPs) with a pleiotropic effect on both asthma and COPD, and to evaluate the similarities between their genetic underpinnings. We performed a genome-wide association study (GWAS) of asthma and COPD in 7,828 Koreans from three hospitals and investigated genetic correlations. The UK Biobank dataset was used for the replication studies. We found that rs2961757, located near neuromedin U receptor 2 (NMUR2) on chromosome 5, was genome-wide significant (βAsthma-COPD = 0.44, P-valueAsthma-COPD = 3.41 × 10-8), and significant results were replicated with the UK Biobank data (βAsthma-COPD=0.04, P-valueAsthma-COPD = 0.0431). A positive genetic correlation was observed between asthma and COPD (39.8% in the Korean dataset and 49.8% in the UK Biobank dataset). In this study, 40–45% of the genetic effects were common to asthma and COPD. NMUR2 increases the risk of asthma development and suppresses COPD development. This indicates that NMUR2 allows for better differentiation of both diseases, which can facilitate tailored medical therapy.
Diverse analytical wave solutions and dynamical behaviors of the new (2+1)-dimensional Sakovich equation emerging in fluid dynamics
Authors: Kumar Sachin , RANI SETU , Mann Nikita
Published: May 2022

Under investigation, this paper constructs an improved and comprehensive class of analytical wave solutions to the (2+1)-dimensional Sakovich equation, a nonlinear evolution equation that plays a remarkable role in condensed physics, fiber optics, and fluid dynamics. By applying relatively, two renewed techniques named Lie symmetry analysis and extended Jacobian elliptic function expansion method, some standard class of new and wide-spectrum closed-form solutions are established in terms of trigonometric, hyperbolic, and Jacobi elliptic functions. These ascertained solutions contain several ascendant parameters that play a crucial role in describing the inner mechanism of a given physical model. Therefore, the obtained wave solutions are demonstrated graphically by three- and two-dimensional graphics using Mathematica. In addition, a couple of varieties of solutions, including multi soliton, periodic soliton, Bell-shaped, and parabolic profile, are depicted for the suitable values of the included parameters. Finally, it must be noted that the variation in obtained wave profiles by the change in subsidiary parameters reveals the parameter effects on the wave. This study ensures that the forgoing techniques are practical and may be used to seek the solitary solitons to a diversity of nonlinear evolution equations (NLEEs).
A survey study of the adherence to the 2020 ACC/AHA heart failure guideline in low-middle income countries (Gaza Strip as an example)
Authors: Alsaiqali Mahmoud , Al-Saikaly Ghassan , AboAbdo Mohammad , mezead Mohammad , Mansour Zakaria , AlZaharna Alaaeddin , Al-Sadawi Mohammed , Mhanna Mohammed , Habib Mohammed
Published: May 2022

BackgroundAcute heart failure is associated with higher post-discharge mortality, especially in low-middle income countries (LMIC). There are limited studies on adherence to the recommended post-discharge care guidelines in these settings.ObjectivesTo assess adherence to the 2020 ACC/AHA inpatient heart failure performance and quality measure in Gaza Strip, Palestine.MethodsThe study was a cross-sectional survey study. We chose a stratified random sample from the three different geographical areas across Gaza Strip with numbers proportional to the size of each region. Patients selected were adults (>18 years) admitted to the various hospitals for acute decompensated heart failure between 4/2021 and 12/2021. We collected data through chart review. Measures were β blockers, ACEi/ARB and MRA prescription, and outpatient follow-up. Results reported as proportion with 95% CI.ResultsThe sample size was 155 patients. The mean age was 64 years. 59% were males. The mean length of stay was 2.8 days. β blockers were prescribed to 85.1% [79.5,90.8] of patients. For ACEi/ARB use, it was 42.7% [34.9,50.5]. For MRA, after excluding ineligible patients, it was prescribed in 48.5% [39.9, 57.2]. None of the patients were prescribed hydralazine/nitrate. Only 30.1% [ 23.6, 38.1] of patients had an outpatient appointment. The median time between discharge and appointment date was 22 days. Only 9.7% [5.0,14.3] of patients were discharged with all quality measures fulfilled.Conclusion There are considerable gaps in the post-discharge care of heart failure patients in the Gaza Strip. There is a need to develop local care guidelines to improve care.
Expression and clinical significance of PRKDC in lung cancer based on bioinformatics analysis
Authors: Guo Yikun , Yang Mengxia , Liu Xingxing , Liu Yanbin , Yan Jun
Published: May 2022

Objective: To investigate the expression and prognostic significance of protein kinase DNA activated catalytic subunit (PRKDC) in non-small cell lung cancer (NSCLC). Methods: oncomine, ualcan, human protein Altas, Kaplan Meier plot and c-bioportal databases were searched to analyze the mRNA expression, protein expression, clinicopathological parameters, prognosis, survival and gene mutation of PRKDC in NSCLC and normal lung tissues.Results: the overexpression of PRKDC mRNA and protein in pathological tissues was significantly correlated with the stage of lung adenocarcinoma (luad) and lung squamous cell carcinoma (lusc), smoking habits, gender, race and lymph node metastasis, and significantly correlated with the shortening of overall survival rate (OS) of NSCLC patients. At the same time, PRKDC had a high mutation rate in NSCLC（ LUAD:23% ，LUSC:19% ）The patients with luad had shorter OS and disease-free survival Survival rate (DPS) was significantly correlated.Conclusion: PRKDC may be a biomarker for the prognosis of NSCLC patients.
COVID Stress, Socioeconomic Deprivation, and Intimate Partner Aggression During the COVID-19 Pandemic
Authors: Hammett Julia Friederike , Halmos Miklós B. , Parrott Dominic J. , Stappenbeck Cynthia A.
Published: May 2022

Background: Intimate partner aggression (IPA) is a prevalent public health concern that is associated with multiple negative consequences. Rates of IPA in the U.S. have increased since the onset of the Coronavirus Disease 2019 (COVID-19) pandemic, likely due to stress associated with the pandemic. Socioeconomic deprivation is associated with COVID-19 outcomes as well as IPA. However, whether socioeconomic deprivation interacts with COVID-19 stress in predicting IPA remains unclear. Methods: Using a sample of 510 individuals recruited via Qualtrics Research Services in April 2020, the present study tested whether socioeconomic deprivation moderates the association between COVID-19 stress and IPA perpetration and victimization. Participants completed a questionnaire battery that included measures of COVID-19 stressors and physical and psychological IPA perpetration and victimization. In addition, participants reported their residential zip codes, which were subsequently matched with scores on the Social Deprivation Index, a composite measure of seven demographic variables from the 5-year American Community Survey. Results: Sequential generalized linear models in Mplus Version 8.7 showed that the effects of COVID-19 stress on physical IPA perpetration and psychological IPA victimization can be best understood through its interactive effects with socioeconomic deprivation. Higher COVID-19 stress was associated with higher levels of physical IPA perpetration and psychological IPA victimization when socioeconomic deprivation was low but not when socioeconomic deprivation was high. Importantly, however, overall rates of IPA were higher among individuals with higher socioeconomic deprivation than among individuals with lower socioeconomic deprivation, regardless of the amount of COVID-19 stress they experienced. Conclusions: The present analyses implicate COVID-19 stress as a critical correlate of IPA and show that the association between this stress and physical IPA perpetration and psychological IPA victimization may be particularly salient among individuals who live in areas of lower socioeconomic deprivation. Furthermore, our results clearly pinpoint the detrimental effects of socioeconomic deprivation more broadly, showing that individuals who live in more deprived areas tend to have high levels of IPA regardless of their level of COVID-19 stress. These findings call for public health policies at the community and societal level that target not only COVID-related stress but also the impacts of socioeconomic inequality.
Identifying Shared Genetic Factors Underlying Epilepsy and Congenital Heart Disease in Europeans
Authors: Wu Yiming , Bayrak Cigdem Sevim , Dong Bosi , He Shixu , Stenson Peter D. , Cooper David N. , Chen Lei , Itan Yuval
Published: May 2022

Epilepsy (EP) and congenital heart disease (CHD) are two apparently unrelated diseases that nevertheless display substantial mutual comorbidity. Thus, whilst congenital heart defects are associated with an elevated risk of developing epilepsy, the incidence of epilepsy in CHD patients correlates with CHD severity. Although genetic determinants have been postulated to underlie the comorbidity of EP and CHD, the precise genetic etiology is unknown. We performed variant and gene association analyses on EP and CHD patients separately, using whole exomes of genetically identified Europeans from the UK Biobank and Mount Sinai BioMe Biobank. We prioritized biologically plausible candidate genes and investigated the enriched pathways and other identified comorbidities by biological proximity calculation, pathway analyses, and gene-level phenome-wide association studies. Our variant- and gene-level results point to the Voltage-Gated Calcium Channels (VGCC) pathway being a unifying framework for EP and CHD comorbidity. Additionally, pathway-level analyses indicated that the functions of disease-associated genes partially overlap between the two disease entities. Lastly, phenome-wide association analyses of prioritized candidate genes revealed that cerebral blood flow and ulcerative colitis constitute the two main traits associated with both EP and CHD.
Impacts of pregnane X receptor and cytochrome P450 oxidoreductase gene polymorphisms on trough concentrations of apixaban in patients with non-valvular atrial fibrillation.
Authors: Nakagawa Junichi , Kinjo Takahiko , Aiuchi Naoya , Ueno Kayo , Tomita Hirofumi , Niioka Takenori
Published: May 2022

Purpose: We examined the impact of polymorphisms in genes encoding cytochrome P450 (CYP) 3A5 (gene code CYP3A5), P-glycoprotein (ABCB1), breast cancer resistance protein (ABCG2), cytochrome P450 oxidoreductase (POR) and pregnane X receptor (PXR; NR1I2) on the steady-state trough concentrations (C0h) of apixaban. Methods: The analyses included 86 patients with non-valvular atrial fibrillation (NVAF) undergoing AF catheter ablation. The CYP3A5*3; ABCG2 421C>A; ABCB1 1236C>T, 2677G>A/T, 3435C>T, and 2482-2236G>A; NR1I2 11156A>C, 11193T>C, and 8055C>T; and POR*28 genotypes were determined. The combination of the noted NR1I2 genotypes determined the PXR*1B haplotype. Results: Stepwise selection multiple linear regression analyses demonstrated that decreased creatinine clearance and the PXR*1B/*1B genotype correlated with increased apixaban C0h, while the presence of the POR*28 allele correlated with decreased C0h (partial R2 = 0.196, 0.057, and 0.046, all P < 0.05). The C0h of apixaban showed a moderate correlation with prothrombin time (r = 0.594 P < 0.001). Conclusion: The PXR*1B haplotype and POR*28 genotype statuses, which involve genes that impact the expression of multiple drug-metabolizing enzymes and drug-transporters, may affect the C0h of apixaban.
WITHDRAWN: The role of maintaining the integrity of sexual response cycle in the improvements of ovulation rate and pregnancy outcomes
Authors: Tang Jiexin , Lu Danhua , Jiang Caixia , Wang Zhilin , Xie Yucen , Zhang Dan
Published: May 2022

Background
Previous studies reported that the timing and frequency of intercourse were associated with the menstrual cycle and immune response, with fewer research on the correlation between sexual response cycle and ovulation rate or pregnancy outcomes.
Methods
We performed a prospective cohort study of 150 patients undergoing ultrasonic ovulation monitoring, with guidance on sexual behavior, psychological counseling, alkalizate on of the vaginal environment conducted for the experimental group(n = 75).
Outcomes:
The overall score of FSFI questionnaire, the score of sexual satisfaction degree, the incidence of orgasm in coitus, the pre-pregnancy cycle of ovulation monitoring, periodic ovulation rate, clinical pregnancy rate, biochemical pregnancy rate, live birth rate and abortion rate of the two groups were analyzed.
Results
After intervention, the incidence of FSD in the experimental group was decreased, with an improvement in sexual satisfaction degree and a higher incidence of orgasm. The periodic ovulation rate, clinical pregnancy rate and live birth rate in the experimental group were significantly higher, with shorter average pre-pregnancy cycle of ovulation monitoring. Furthermore, there were no differences in biochemical pregnancy rate and abortion rate.
Conclusion
Taken together, guidance on sexual behavior not only enhance the relationship between couples and alleviate sexual dysfunction, but also have crucial reproductive significance.
Tight Adherent Feature on Optical Coherence Tomography Predict Postoperative Visual Outcome in Epiretinal Membrane Eyes
Authors: Lai Tzu-Ting , Wu Li-Li , Hsieh Yi-Ting , Lee Chia-Chen , Peng Yi-Jie
Published: May 2022

Background: To identify the predictive parameter among preoperative measurements that best predicts postoperative visual outcome in the epiretinal membrane (ERM). Methods: Thirty-three consecutive patients with idiopathic unilateral ERM patients between 2015 and 2018 were enrolled. Nineteen healthy normal eyes were selected as an independent age-matched group. Based on preoperative optical coherence tomography (OCT), we further divided the patients with ERM into two groups: type 1, loosely attached ERM, and type 2, tight adherent ERM. We documented the vision and thickness of various retinal layers: nerve fiber layer, ganglion cell layer, inner plexiform layer (GCL+IPL), inner nuclear layer (INL), outer retinal layer (ORL), and retinal pigment epithelium/Bruch complex layer before and after the surgery. The association between postoperative visual acuity and these variables was analyzed using multiple linear regression analysis. Results: All retinal layers of ERM eyes were thicker than the normal eyes (P < 0.05). Among ERMs, we identified 11 eyes with type 1 adhesions and 22 eyes with type 2 adhesions. The preoperative GCL + IPL layers were significantly thicker in type 2 patients than in type 1 patients (93.67±33.03 um vs 167.71±13.77 um; p=0.023). Greater GCL+IPL thickness was correlated with a worse postoperative visual acuity and multiple linear regression analysis showed that GCL+IPL thickness was an independent predictor of postoperative visual acuity (VA) (beta value=0.689; p=0.012). A greater thickness of GCL+IPL layers of type 2 patients had worse postoperative best-corrected visual acuity (BCVA) (p=0.028). Ectopic inner foveal layers with disappearance of fovea pit were persistently presented in OCT profiles of both groups. Conclusion: Idiopathic ERM demonstrated significantly thicker inner retinal layers (GCL + IPL and INL). However, the ORL thickness was similar between the normal eyes and ERM eyes. The preoperative GCL + IPL layers were significantly thicker in patients with type 2 ERM than that in patients with type 1 ERM. The increase in GCL+IPL thickness was significantly correlated with worse postoperative visual outcomes.
Docking, Molecular Dynamic Simulation and ADMET Analysis of Novel Honokiol Derivatives against Breast Cancer Target Protein LKB1
Authors: Shahid Izzah , Raza Rabail Zehra , Akbar Ansa , Abbasi Sumra Wajid , Mehnaz Samina
Published: May 2022

Breast cancer is characterized by an uncontrolled cell growth in the breast tissue and is a leading cause of death globally. Cytotoxic effects and reduced efficacy of currently used therapeutics insist to look for new chemo-preventive strategies against breast cancer. LKB1 gene has recently been categorized as a tumor suppressor gene where it’s inactivation can cause sporadic carcinomas in various tissues, including the breast. Mutations in the highly conserved LKB1 catalytic domain leads to the loss of function and subsequently elevated expression of pluripotency factors in breast cancer. The utilization of drug-likeness filters and molecular simulation has helped evaluate the pharmacological activity and binding abilities of selected drug candidates against the target proteins in many cancer studies. The current in silico study provides a pharmacoinformatic approach to decipher the potential of novel honokiol derivatives as therapeutic agents against breast cancer through binding of target LKB1 protein. Among the three honokiol derivatives, ligand-protein binding energy of 3' formylhonokiol with LKB1 protein was found to be the highest via molecular docking. Moreover, stability and compactness inferred for 3' formylhonokiol with LKB1 is suggestive of 3' formylhonokiol being an effective activator of LKB1 via simulation studies. It was further established that 3' formylhonokiol displays an excellent profile of distribution, metabolism, and absorption, indicating it as an anticipated future drug candidate.
Implementation of a regional standardised model for perinatal electronic medical records
Authors: Leante-Castellanos José Luis , Mañas-Uxó María Isabel , Garnica-Martínez Beatriz , Tomás-Lizcano Aurora , Muñoz-Soto Andrés
Published: May 2022

Background: Electronic recording of newborn health information contributes to improving the quality of care. Nonetheless, there is limited evidence on the implementation of perinatal electronic medical records models. We describe the development and implementation of an electronic recording model that includes data on the health care provided to both the mother and the newborn, standardised for six hospitals of a regional health care system.Methods:The implementation process was developed in 2 stages. During stage 1, the tool was introduced in hospitals to stablish first contact with the healthcare staff. The second stage consisted in designing a new strategy to stabilise the model. Technical issues were fixed, and a new version was drawn up based on multidisciplinary agreement. Indicators to monitor implementation were measured in both stages and compared using the chi-squared test. Results:During stage 1, nearly every newborn got its electronic medical record with an appropriate connection to the mother’s data. However, certain forms that were meant to be filled in by staff were frequently neglected (completion rates: 36.7%-55.3%). In stage 2, there was a statistically significant increase in the completion rates of all these forms. As a result, a standardised discharge report was provided to every newborn at the end of stage 2. Conclusions: Implementation of perinatal electronic medical records that link maternal and neonatal data is complicated and experience in this area is limited. Here we describe the implementation process of a model that was reliable and standardised for an entire regional health care system.
Detoxification enzymes: comparative analysis across hemipteran species
Authors: Volonté Mariano , Traverso Lucila , Estivalis Jose Manuel Latorre , Almeida Francisca Cunha , Ons Sheila
Published: May 2022

Background:
Hemiptera is one of the most speciose Orders of insects, and the most speciose considering hemimetabolous. Through their evolutive history, hemipterans with different feeding habits have adapted to deal with different chemical challenges. Three major gene families are involved in xenobiotic detoxification in insects: the cytochromes P450 (CYPs), carboxyl/cholinesterases (CCEs), and glutathione transferases (GSTs). Here we perform a comparative analysis on the complement of these gene superfamilies across five hemipteran species; four heteropterans (the plant feeders pentatomids Nezara viridula and Halyomorpha halys; the hematophagous Cimex lectularius, Cimicidae, and Rhodnius prolixus, Reduviidae), and one plant feeder Auchenorryncha (Nilaparvata lugens).
Results:
Our results point to an expansion of several enzyme families associated to xenobiotic detoxification in heteropterans respect to other species, and present a dynamic evolution pattern including CYP3 clan, hormone and pheromone processing class in the CCE superfamily and Sigma class in GST superfamily. Other detoxification-related families are reduced in the Hemiptera species analyzed here: reduction or even absence of class Epsilon and reduced class Delta in GST superfamily; absence of mitochondrial family CYP12; absence of CYP9 family in CYP3 clan; and reduction or even absence of some dietary/detoxification groups of CCEs. Interestingly, the most polyphagous species analyzed here (H. halys), is also the one that presents the larger repertoire of detoxification enzymes. Gene-cluster analysis suggests that this could be due to gene duplication events.
Conclusions:
The evolutionary analysis performed here reveals characteristics that are both common and particular for heteropterans. The composition and organization of detox-related gene families could shed light on evolutionary forces that shaped their divergence. These families are both important for the detoxification of diet products and to confer tolerance or resistance to synthetic insecticides. Furthermore, we present here the first comprehensive analysis of detoxificant gene superfamilies in N. viridula, an understudied species in spite of its economic relevance as a crop pest. The information obtained is of interest for basic insect science, as much as for the control of harmful species and the management of insecticide resistance.
Tinetti balance performance is associated with mortality in older adults with Parkinson’s disease: a longitudinal study
Authors: Laurent Louise , Koskas Pierre , Estrada Janina , Sebbagh Mélanie , Lacaille Sophie , Raynaud-Simon Agathe , Lilamand Matthieu
Published: May 2022

Background: Parkinson’s disease (PD) is associated with a 3-fold increased risk of death and this mortality risk is closely related to advancing age. Evidence is lacking regarding the factors associated with the risks of mortality or nursing-home (NH) admission, in elderly patients with PD. We aimed at identifying the clinical characteristics associated with these outcomes, in older community dwelling patients with PD.Methods: Retrospective, observational analysis of data from patients referred to our geriatric day hospital. Motor assessment included Unified Parkinson Disease Rating Scale (UPDRS) score and UPDRS axial sub-score, Tinetti Performance Oriented Mobility Assessment (POMA) balance and gait tests, and gait speed. Levodopa equivalent dose, comorbidity, cognitive performance, functional status (basic and instrumental Activities of Daily Living) were examined. Cox proportional hazards models were performed to identify the factors associated with 5-year mortality and NH admission rate. Results: We included 98 patients (mean age 79.4±5.3) of whom 18 (18.3%) died and 19 (19.4%) were admitted into NH over the 5-year follow-up. In multivariate Cox models, poor balance on the Tinetti POMA scale (HR=0,82 95%CI (0.66-0.96), p=0.02) and older age (HR= 1,12 95%CI (1.01-1.25), p=0,04) were the only variables significantly associated with increased mortality risk. A Tinetti balance score below 11/16 was associated with a 6.7 hazard for 5-year mortality (p<0.01). No specific factor was associated with NH admissions.Conclusions: The Tinetti POMA test may be an accurate instrument for identifying the older individuals with PD at higher risk of mortality, and should be considered in clinical setting.
Da Vinci Xi: a better platform for robotic-assisted radical prostatectomy?
Authors: Chen Yi-Hsuan , Chen Marcelo , Lin Wun-Rong , Chiu Allen W. , Chen Li-Chen
Published: May 2022

BackgroundAn upgraded surgical robot platform, da Vinci Xi, had demonstrated multiple advantages over the previous da Vinci Si system. Better surgical outcomes had been reported in various operations except for robotic-assisted radical prostatectomy (RARP). We sought to compare and analyze the outcomes of RARP between using the da Vinci Xi and the da Vinci Si. The learning curve of docking with the new surgical robot and method for RARP was also evaluated.MethodsAn initial series of 77 RARPs have since been performed with the side docking technique since the installation of the da Vinci Xi. Another series of 96 consecutive RARPs were performed immediately before the uptake using the da Vinci Si and central docking technique. We compared the clinicopathological, perioperative, and postoperative outcomes of these two groups. We also analyzed the learning curve of the transition from central docking with the da Vinci Si to side docking with the da Vinci Xi.ResultsThe Xi group had a shorter console time (208.2 vs. 285.7 min, p=0.004), less estimated blood loss (193.5 vs. 259.9 mL, p=0.018), and faster docking time (5.12 vs. 7.95 min, p=0.002) than the Si group. There were no significant differences regarding perioperative and postoperative outcomes. The plateau of the learning curve of side docking with the da Vinci Xi system was reached after 27 cases, and led to a significantly shorter docking time than before completing the learning curve (3.72 vs. 7.70 min, p<0.001).ConclusionPerforming RARP with the da Vinci Xi system and side docking improved intraoperative outcomes and the docking time was almost negligible after gaining sufficient experience with the new system and docking technique. However, the complication rate and postoperative outcomes did not significantly benefit from the da Vinci Xi model.
Association between weight loss and outcomes in patients undergoing atrial fibrillation ablation: A systematic review and dose-response meta
Authors: Zhao Huilei , Li Xiaozhong , Yu Peng , Liu Menglu , Ma Jianyong , Wang Jinfeng , Zhu Wengen , liu xiao
Published: May 2022

Objectives: This study aims to determine the relationship between weight loss and outcomes in patients with atrial fibrillation (AF) ablation, as well as the potential dose-response relationship.Background: Obesity is an independent risk factor for AF, and obesity can affect the prognosis of AF. However, the role of weight loss on outcomes after ablation remains unclear.Methods: The Cochrane Library, PubMed, and Embase databases were searched to identify studies that reported a relationship between weight loss and ablation up to August 17, 2021. Relative risks (RRs) were pooled using random-effects models.Results: One randomized, open-labeled clinical trial and seven cohort studies involving 1150 patients were included. The mean body mass index of all included studies was over 30 kg/m2. The clinical trial showed nonsignificant benefit of weight loss intervention on AF recurrence (odd risk=1.02, 95% confidence interval [CI]: 0.70-1.47). Meta-analysis based on observational studies showed that the recurrence rate of AF after ablation was significantly reduced (RR=0.43, 95% CI: 0.22-0.81, I2 =97%) in relatively obesity patients with weight loss compared with the control group (morbidly obese patients without weight change). Each 10% reduction in weight was associated with a decreased risk of AF recurrence after ablation (RR=0.54, 95% CI: 0.33-0.88) with high statistical heterogeneity (I2 =76%). An inverse linear association (Pnon-linearity =0.27) between AF relapse and increasing weight loss was found.Conclusions: Our results first suggest an inverse dose-response association between weight loss in risk of recurrent AF after ablation in obese patients.
A Space-Time Coupled Lagrangian/semi-Lagrangian Meshfree Hydromechanical Formulation for Landslide Modeling
Authors: Baek Jonghyuk , Schlinkman Ryan T. , Chen Jiun-Shyan
Published: May 2022

The numerical modelling of natural disasters such as landslides presents several challenges for conventional mesh-based methods such as the finite element method (FEM) due to the presence of numerically challenging phenomena such as severe material deformation and fragmentation. In contrast, meshfree methods such as the reproducing kernel particle method (RKPM) possess unique features conducive to modelling extreme events such as the absence of a structured mesh and the ease of adaptive refinement, among others. While semi-Lagrangian RKPM (SL RK) where the kernel functions are defined in the current configuration has proven to be effective in extreme event modelling, the computational cost for the re-evaluation of the shape functions every time step is a drawback. A selective employment of SL RK approximation can be a remedy, but the region where the SL RK approximation is needed cannot be pre-determined in most cases. In this work, a space-time evolving coupling of the Lagrangian and SL RK approximations is proposed for the solution of a hydro-mechanical formulation for efficient and accurate simulations of landslides where regions of severe deformation cannot be predetermined. This formulation utilizes a Lagrangian formulation for regions of the model where deformation is not severe while those regions with severe deformation are described by a semiLagrangian formulation where the shape functions are updated at each time step. The coupling is achieved using equivalent plastic strain as a space-time transition from Lagrangian shape functions to semi-Lagrangian ones as deformation progresses. The particular focus of the paper will be on modelling seepage-induced landslide with a mixed 𝑢-𝑝 formulation to effectively couple the solid and fluid phases. Examples which demonstrate the effectiveness of this coupled L-SL RKPM, include a wave propagation in poroelastic media, a poroplastic soil cylinder impact problem, and a seepage-induced levee failure leading to landslide.