bluuebunny/crossref_metadata_2025 huggingface dataset:
Technological Prospecting: Mapping Patents on L-asparaginases from Extremophilic Microorganisms
Authors: de Oliveira Lima Igor Gomes , Bispo James Romero Soares , da Silva Maurício Bernardo , de Oliveira Feitosa Alexya , dos Santos Ana Caroline Melo , Moreira Magna Suzana Alexandre , Passarini Michel Rodrigo Zambrano , Saraiva Câmara Paulo Eduardo Aguiar , Rosa Luiz Henrique , Oliveira Valéria Maia , de Queiroz Aline Cavalcanti , Duarte Alysson Wagner Fernandes
Published: August 2021

Background:

L-asparaginase (L-ASNase, L-asparagine amidohydrolase, E.C.3.5.1.1) is an enzyme
with wide therapeutic applicability. Currently, the commercialized L-ASNase comes from mesophilic organisms,
presenting low specificity to the substrate and limitations regarding thermostability and active pH
range. Such factors prevent the maximum performance of the enzyme in different applications. Therefore, extremophilic
organisms may represent important candidates for obtaining amidohydrolases with particular characteristics
desired by the biotechnological market.

Objective:

The present study aims to carry out a technological prospecting of patents related to the L-asparaginases
derived from extremophilic organisms, contributing to pave the way for further rational investigation and
application of such enzymes.

Methods:

This patent literature review used six patents databases: The LENS, WIPO, EPO, USPTO, Patent Inspiration,
and INPI.

Results:

It was analyzed 2860 patents, and 14 were selected according to combinations of descriptors and study criteria.
Approximately 57.14% of the patents refer to enzymes obtained from archaea, especially from the speciesPyrococcus
yayanosii (35.71% of the totality).

Conclusion:

The present prospective study has singular relevance since there are no recent patent reviews for L-asparaginases,
especially produced by extremophilic microorganisms. Although such enzymes have well-defined applications,
corroborated by the patents compiled in this review, the most recent studies allude to new uses, such as the treatment
of infections. The characterization of the catalytic profiles allows us to infer that there are potential sources still
unexplored. Hence, the search for new L-ASNases with different characteristics will continue to grow in the coming
years and, possibly, ramifications of the technological routes will be witnessed.
Effects of Prokinetics on the Digestive Tract
Authors: Usai-Satta Paolo , Lai Mariantonia , Oppia Francesco , Cabras Francesco
Published: August 2021

Background:

Functional gastrointestinal disorders account for at least a third of visits to
gastroenterology clinics. Despite pathophysiological complexity, impaired gut motility may be frequently
present in these disorders.

Introduction:

Prokinetics are a class of drugs that promote gastrointestinal motility, accelerate transit,
and potentially improve digestive symptoms. Several prokinetic agents with a great variety of mechanisms
of action are available.

Aim:

The purpose of this paper is to update our current knowledge about the efficacy and safety of prokinetics.

Methods:

A literature search on efficacy and safety of prokinetics was carried out using the online databases
of Pubmed, Medline, and Cochrane.

Results :

Based on the action of different receptors, prokinetics mainly comprise dopamine antagonists,
5HT4 agonists, motilin agonists, ghrelin agonists, and cholinergic agonists. Prokinetics have the
potential to improve motility function in all segments of the digestive tract, from the esophagus to the
colon. In particular, drug international agencies have approved antidopaminergic metoclopramide for
the treatment of gastroparesis and serotoninergic prucalopride for chronic constipation not responsive
to traditional laxatives. Arrhythmias by QT prolongation and galactorrhea by prolactin stimulation are
the more frequent side effects related to prokinetics use.

Conclusions:

Old and new prokinetics are effective in ameliorating digestive motility disorders and related
symptoms and are widely prescribed. Special attention should be paid to the potential adverse
events of these agents.
Evaluación térmica de modificaciones en las envolventes de módulos experimentales ubicados en el centro poblado de Imata (4519 msnm), Arequipa
Authors: Ponce Gonzales Martín Concepción , Molina-Fuertes Juan Omar , Horn-Mutschler Manfred Josef , Gómez-León Mónica Marcela
Published: August 2021

Este trabajo analiza los diferentes aportes térmicos y energéticos dinámicos de las diferentes propuestas de modificaciones realizados en las envolventes de dos módulos experimentales de vivienda construidos en el centro poblado de Imata, Arequipa a 4519 msnm. Los módulos fueron construidos con características constructivas del lugar y diseño típico, posteriormente se realizaron modificaciones como cambiar el material de cubierta del techo, enlucido de las paredes de adobe con yeso, colocación de claraboyas en el techo y falso techo, aislamiento del falso techo, y construcción de un invernadero adosado en uno de los módulos. El registro de datos consistió en medir la temperatura del aire interior de los módulos e invernadero adosado, además, del registro de datos meteorológicos exteriores, utilizando una estación Davis ubicada en lo alto de la municipalidad de Imata. La temperatura media diaria del aire interior del módulo sin invernadero (M1) inicialmente fue de 3,1 °C, siendo la temperatura media diaria exterior 0,61 °C; con las modificaciones de las envolventes, la temperatura media del aire interior de M1 fue 10 °C, aportando en promedio al interior 6,9 °C; para el módulo con invernadero (M2), la temperatura media del aire interior fue de 14, 6 °C, aportando en promedio al interior 11,5 °C con una diferencia promedio de 5,17 °C por encima de M1. Los resultados obtenidos demuestran el aporte de las modificaciones y técnicas bioclimáticas implementadas como el caso del invernadero adosado que para las zonas Altoandinas por su potencial solar se presentan idóneos y eficaces.
Diseño box – Behnken para optimizar el rendimiento de un pico sistema solar fotovoltaico
Authors: Delzo Salomé Armando Siles , Huari Vila Oscar Paul , Salazar Mercado Jorge Edgar , Casimiro Soriano Enzo Martin
Published: August 2021

El objetivo de la investigación fue diseñar un sistema Box Behnken para optimizar el rendimiento de un pico sistema solar fotovoltaico en el Valle del Mantaro en condiciones de alta densidad poblacional. Para ello se ubicó el sistema en una zona de moderada densidad urbana de la ciudad de Huancayo, región Junín, en la región central del Perú con coordenadas 12°03'29,0"S 75°13'12,9"W. Las mediciones se realizaron en la temporada de verano regional. Las variables evaluadas para su optimización en el Diseño Box Behnken fueron: orientación, ángulo de inclinación del panel solar y la hora de exposición. Se modeló el comportamiento mediante la superficie de respuesta para variables únicas y combinadas, comparándose la variación en la diferencia de potencial (V). Los resultados mostraron que la variable de mayor significación para la variación de potencial fue el ángulo de inclinación, con un efecto estandarizado de 3,48 y 95% de significancia. Todos los residuos del diagrama factorial se encontraron dentro de +0,8 y -0,8, indicando que el procedimiento experimental aplicando el método Box Behnken no presentó valores atípicos. Se concluyó que es posible maximizar la diferencia de potencial de un sistema de captación solar en el Valle del Mantaro, en una zona de alta densidad urbana, priorizando el ángulo de incidencia de radiación.
Codeposición electrolítica de zinc y niquel con fines de mejorar el galvanizado industrial estándar
Authors: Villon Angel Eduardo , Cruz Contreras Jes´ús
Published: August 2021

Se logró un galvanizado mejorado con la codeposición de Zn y Ni, mejorando la dureza a valores de 140-148 HV y una velocidad de corrosión de 4.8-6.4 mpy con un depósito de 9.8% de Ni y 90.2% de zinc, con un baño de sales de sulfato de Ni y Zn a pH 1-3, usando como aditivos tiourea, gluconato de sodio y ácido bórico entre otros, con densidades de corriente diferenciados para cada ánodo, de níquel y el de zinc, corrientes totales de 5-6 A/dm2, los tiempos utilizados fueron los suficientes para provocar un espesor adecuado para ensayos de 10-15 minutos, con una celda electrolítica con agitación, con eficiencia catódicas de 48 a 65%.
Identificación de Cadmio y Plomo en los cultivos de Cacao ubicados en la zona de Satipo - Junín
Authors: Rosales Huamani Jimmy Aurelio , Centeno Rojas Luis , Cajacuri Perez Jhomara Ruth , Breña Ore Jorge , Chávez Chapana Carlos
Published: August 2021

La presencia de metales pesados en los cultivos de cacao es actualmente un grave problema para los agricultores y productores de diversas regiones del Perú. Las exportaciones de cacao y sus derivados a los mercados europeos se ven amenazados por posibles indicios de contaminación de metales pesados en granos de cacao exportables, algunos en niveles superiores a los permitidos por normativas alimentarias establecidas por la Comunidad Europea, las cuales están orientadas a la protección de los consumidores. Se consideran que las posibles fuentes de contaminación del Cd en los cultivos de cacao pueden provenir de actividades naturales como actividades volcánicas, procesos de erosión y sedimentación en rocas que contiene minerales con un alto contenido en estos metales pesados. También esta contaminación es debido a las actividades antropogénicas como la minería de yacimientos asociados, la agricultura (uso de fertilizantes), fundición de minerales y la quema de combustibles fósiles. Debido a que actualmente, no se tiene información de contenidos de metales pesados como Cadmio (Cd) y Plomo (Pb) en una zona de estudio ubicada en Satipo-Junín, en el presente trabajo hacemos un estudio de dicha región, utilizando una metodología para la obtención de las concentraciones de metales de Cd y Pb presentes en el suelo de cultivos de cacao tipo forastero. Como consecuencia de este estudio determinamos y concluimos que las concentraciones obtenidas de Cd y Pb en suelos son menores a los estándares establecidos por el Ministerio de Medio Ambiente (MINAM), además generamos el mapa geoquímico de la zona de estudio con estos metales.
Planificación de movimiento mediante algoritmo de campos potenciales con optimizacion de parametros aplicado a un manipulador antropomorfico de 6 GLD
Authors: Alcántara Tacora Sandro Manuel , López Zapata Erwin Daniel , Peralta Toribio Jesús , Rodríguez Bustinza Ricardo Raúl
Published: August 2021

En este trabajo se desarrolla una variación del algoritmo de campos potenciales para la planificación de trayectorias que evita obstáculos aplicado a un manipulador antropomórfico de 6 grados de libertad. En primera instancia se generó el modelo de cinemática inversa basada en un proceso de control iterativo multivariable, luego se modificó el modelo agregando un vector de rotación obtenido por las fuerzas repulsivas entre el obstáculo y las seis articulaciones del robot de manera que el manipulador pueda encontrar una ruta que evite el obstáculo y alcance una posición objetivo. Este modelo final de cinemática inversa con campos potenciales genera trayectorias que dependen del parámetro de velocidad de optimización y de los coeficientes de campos vectoriales. Con el objetivo de optimizar las trayectorias se generó una base de datos con los puntos iniciales, finales y de obstáculos de diferentes trayectorias con sus respectivos parámetros optimizados para entrenar una red neuronal supervisada. Los resultados muestran que la red neuronal debe entrenarse con una mayor cantidad de datos debido a que se calculan parámetros erróneos para ciertas posiciones iniciales y finales. Finalmente, la simulación del manipulador de 6 grados de libertad que sigue la trayectoria generada por el modelo de cinemática inversa y campos potenciales con los parámetros optimizados calculados empíricamente resultan en un modelo con un comportamiento adecuado logrando evitar los obstáculos.
Perencanaan Pembangunan Kawasan Ekowisata Taman Buah Jeruk Kabupaten Malang (Studi di Dinas Pariwisata dan Kebudayaan Kabupaten Malang)
Authors: Wiyanti Titik
Published: August 2021

This research aims to analyse the development planning of the area of the Jeru Fruit garden in Malang District (study at the Tourism and Culture Office of Malang District). Researchers analyzed development planning using 6 (six) components, namely The decision to adopt planning, collect and analyse data, identyfing alternatives course of action, plan and project appraisal, implement, and monitoring and evaluation. The type of research used is descriptive research with a qualitative approach. The results of the research show that development planning is seen from 6 (six) components, that the implementation of the ecotourism area of Jeru Fruit Park in Malang district has been more than 4 (four) years but in fact there are still many activities have not been carried out optimally, such as the many physical results of development that has been completed but still not be utilized because of the lack of management certainty that can generate income as a source of Original Local Government Revenue.
Pengaruh Pengembangan Sumber Daya Manusia dan Disiplin Kerja terhadap Kinerja Pegawai (Studi pada Bagian Umum dan Hukum Tata Laksana Universitas Brawijaya)
Authors: Lusianita Maria
Published: August 2021

Employees in an agency need to be managed professionally in order to achieve a balance between the needs of employees and the guidance untill their capabilities of the agency. Organizations benefit from operational continuity with increased performance, while employees feel they have a greater commitment to the organization. In line with the phenomenon of human resource development, employee work discipline must also be developed. This study aims to explain the impact of human resource development and work discipline on non-PNS employees and employees. The results of the study state that the development of human resources on employee performance shows a positive but insignificant effect, besides that the effect of work discipline on employee performance shows a positive and significant effect. In addition, the moderating effects of age, work status, and years of service also do not have a significant effect.
Strategi Pemerintah Daerah dalam Tinjauan Program Kota Tanpa Kumuh (Studi pada Kelurahan Gading Kasri, Kecamatan Klojen, Kota Malang)
Authors: Ulum M. Chazienul , Anggraini Dini Heksa
Published: August 2021

The problem of slum settlements is a big challenge for both central and local governments. To overcome this problem, the Directorate General of Human Settlements conducted national development through the City Without Slum (KOTAKU) program. KOTAKU is a program to manage slum settlements into habitable settlements through community-based infrastructure development. Kelurahan Gading Kasri of Malang City is one of the sub-districts chosen by the Malang City Government to implement the City Without Slums program. Strategies in handling the slum areas in Gading Kasri Village can be analyzed with the theory of types of strategies by Korten, which include organizational strategies, program strategies, resource support strategies, and institutional strategies.
Volleyball – An Ethnographic Drama
Authors: Blackledge Adrian , Creese Angela
Published: August 2021

In this book research in process and research findings are represented in a play script which brings vividly to life both ethnographic research methods and communication in the world of sport. This highly original book brings innovation and imagination to the representation of language in social life.
Multilingual Testing and Assessment
Authors: De Angelis Gessica
Published: August 2021

This book addresses the need for research and guidance on testing multilingual students. The author introduces an integrated approach to testing and assessment; provides guidelines for test-writers, teachers and educators; and demonstrates how to use the integrated approach to testing and assessment in a multilingual educational context.
Validity and Reliability of the Self-administered Psycho-TherApy-SystemS (SELFPASS) Item Pool for the Daily Mood Tracking of Depressive Symptoms: Cross-sectional Web-Based Survey
Authors: Mayer Gwendolyn , Hummel Svenja , Gronewold Nadine , Oetjen Neele , Hilbel Thomas , Schultz Jobst-Hendrik
Published: August 2021

Background

e-Mental health apps targeting depression have gained increased attention in mental health care. Daily self-assessment is an essential part of e-mental health apps. The Self-administered Psycho-TherApy-SystemS (SELFPASS) app is a self-management app to manage depressive and comorbid anxiety symptoms of patients with a depression diagnosis. A self-developed item pool with 40 depression items and 12 anxiety items is included to provide symptom-specific suggestions for interventions. However, the psychometric properties of the item pool have not yet been evaluated.

Objective

The aim of this study is to investigate the validity and reliability of the SELFPASS item pool.

Methods

A weblink with the SELFPASS item pool and validated mood assessment scales was distributed to healthy subjects and patients who had received a diagnosis of a depressive disorder within the last year. Two scores were derived from the SELFPASS item pool: SELFPASS depression (SP-D) and SELFPASS anxiety (SP-A). Reliability was examined using Cronbach α. Construct validity was assessed through Pearson correlations with the Patient Health Questionnaire-9 (PHQ-9), the General Anxiety Disorder Scale-7 (GAD-7), and the WHO-5-Wellbeing-Scale (WHO-5). Logistic regression analysis was performed as an indicator for concurrent criterion validity of SP-D and SP-A. Factor analysis was performed to provide information about the underlying factor structure of the item pool. Item-scale correlations were calculated in order to determine item quality.

Results

A total of 284 participants were included, with 192 (67.6%) healthy subjects and 92 (32.4%) patients. Cronbach α was set to .94 for SP-D and α=.88 for SP-A. We found significant positive correlations between SP-D and PHQ-9 scores (r=0.87; P<.001) and between SP-A and GAD-7 scores (r=0.80; P<.001), and negative correlations between SP-D and WHO-5 scores (r=–0.80; P<.001) and between SP-A and WHO-5 scores (r=–0.69; P<.001). Increasing scores of SP-D and SP-A led to increased odds of belonging to the patient group (SP-D: odds ratio 1.03, 95% CI 1.01-1.05; P<.001; SP-A: 1.05, 1.05-1.01; P=.01). The item pool yielded 2 factors: one that consisted of mood-related items and another with somatic-related items.

Conclusions

The SELFPASS item pool showed good psychometric properties in terms of reliability, construct, and criterion validity. The item pool is an appropriate source for daily mood tracking in future e-mental health apps among patients with depression. Our study provides general recommendations for future developments as well as recommendations within the item pool.
Using Biological Feedback to Promote Health Behavior Change in Adults: Protocol for a Scoping Review (Preprint)
Authors: Richardson Kelli M , Saleh Ahlam A , Jospe Michelle R , Liao Yue , Schembre Susan M
Published: August 2021

BACKGROUND

Many health conditions can be prevented, managed, or improved through behavioral interventions. As a component of health behavior change interventions, biological feedback is of particular interest given recent advances in wearable biosensing technology, digital health apps, and personalized health and wellness. Nevertheless, there is a paucity of literature to guide the design and implementation of interventions that incorporate biological feedback to motivate health behavior change.

OBJECTIVE

The goal of this scoping review is to deeply explore the use of biological feedback as a component of health behavior change interventions that target adults. The objectives of the review include (1) mapping the domains of research that incorporate biological feedback and (2) describing the operational characteristics of using biological feedback in the context of health behavior change.

METHODS

A comprehensive list of search terms was developed to capture studies from a wide range of domains. The studies to be included are randomized controlled trials published as primary research articles, theses, or dissertations targeting adults 18 years and older, who use biological feedback to change a health-related behavior. The following electronic databases were searched: Ovid MEDLINE, Embase, Cochrane Central Register of Controlled Trials, EBSCOhost, PsycINFO, and ProQuest Dissertations & Theses Global. The screening and data extraction process will be guided by the Joanna Briggs Institute Manual for Evidence Synthesis and conducted by trained reviewers.

RESULTS

Database searches were completed in June 2021. A total of 50,459 unique records were returned after the removal of 48,634 duplicate records. The scoping review is planned for completion in 2022.

CONCLUSIONS

To our knowledge, this will be the first scoping review to map the literature that uses biological feedback as a component of health behavior change interventions targeting adults. The findings will be used to develop a framework to guide the design and implementation of future health behavior change interventions that incorporate biological feedback.

CLINICALTRIAL

OSF Registries OSF.IO/YP5WA; https://osf.io/yp5wa

INTERNATIONAL REGISTERED REPORT

DERR1-10.2196/32579
Emotional Word Use in Informal Carers of People Living With Dementia: Linguistic Analysis of Online Discussion Forums (Preprint)
Authors: Donnellan Warren James , Warren Jasmine Grace
Published: August 2021

BACKGROUND

Informal dementia care is uniquely stressful and necessitates effective methods of identifying and understanding the needs of potentially at-risk carers so that they can be supported and sustained in their roles. One such method is examining carers’ engagement in online support platforms. Research has explored emotional word use on online discussion forums as a proxy for underlying emotional functioning. We are not aware of any research that has analyzed the content of posts on discussion forums specific to carers of people living with dementia in order to examine their emotional states.

OBJECTIVE

We addressed the following research questions: (1) To what extent does emotional language use differ between carers of people living with dementia and noncarers? (2) To what extent does emotional language use differ between spousal and parental carers? (3) To what extent does emotional language use differ between current and former carers?

METHODS

We used the Linguistic Inquiry and Word Count (LIWC) program to examine emotional word use on a UK-based online forum for informal carers of people living with dementia and a discussion forum control group. Carers were separated into different subgroups for the analysis: current and former, and spousal and parental.

RESULTS

We found that carers of people living with dementia used significantly more negative, but not positive, emotion words than noncarers. Spousal carers used more emotion words overall than parental carers, specifically more negative emotion words. Former carers used more emotional words overall than current carers, specifically more positive words.

CONCLUSIONS

The findings suggest that informal carers of people living with dementia may be at increased risk of negative emotional states relative to noncarers. Greater negativity in spousal carers may be explained by increased caregiver burden, whereas greater positivity in former carers may be explained by functional relief of caregiving responsibilities. The theoretical/applied relevance of these findings is discussed.
Beyond the Biopsy: Monitoring Immune Status in Kidney Recipients
Authors: Bloom Roy D. , Augustine Joshua J.
Published: August 2021

Improved long-term kidney allograft survival is largely related to better outcomes at 12 months, in association with declining acute rejection rates and more efficacious immunosuppression. Finding the right balance between under- and overimmunosuppression or rejection versus immunosuppression toxicity remains one of transplant’s holy grails. In the absence of precise measures of immunosuppression burden, transplant clinicians rely on nonspecific, noninvasive tests and kidney allograft biopsy generally performed for cause. This review appraises recent advances of conventional monitoring strategies and critically examines the plethora of emerging tests utilizing tissue, urine, and blood samples to improve upon the diagnostic precision of allograft surveillance.
La formación del personal de las bibliotecas universitarias españolas: de la euforia a la estabilización
Authors: Blanco Domingo Luis
Published: August 2021

El objetivo de este artículo es analizar de forma cuantitativa cómo se han implementado los cursos de formación entre el personal de las bibliotecas universitarias españolas ante el nuevo paradigma tecnológico y social al que se enfrentan. Se basa en los datos estadísticos que proporciona la Red de Bibliotecas Universitarias Españolas (REBIUN) a través de su plataforma, que permiten concluir que, salvo excepciones, no existe una clara apuesta por su dinamización, situándose la mayoría de los centros en un perfil medio o bajo, con una clara tendencia a la estabilización, y sin que la visibilidad social de la formación sea considerada como un indicador de calidad ni de las competencias profesionales ni de los objetivos de las mismas. Se presentan además una serie de recomendaciones para que la presencia de los cursos de formación adquiera una mayor importancia en la planificación estratégica de las bibliotecas universitarias.
PRINCIPIOS DE NEUROBIOLOGÍA
Authors: Crispino Luis
Published: August 2021

Reseña a cargo del Prof. Dr. Luis Crispino, responsable de la Cátedra de Neurobiología. Departamento de Ciencias Cognitivas y de la Salud. Docente a nivel de Postgrados y de Maestría en la UCUDAL. Docente de la Facultad de Medicina del CLAEH, Uruguay.
NIÑOS DE LA CALLE: BUENOS AIRES SXXI
Authors: Brasesco María Verónica
Published: August 2021

El estudio afronta la problemática del estatus de la infancia y la adolescencia contemporánea  considerando especialmente el fenómeno del consumo de sustancias en niños de calle en la Ciudad de Buenos Aires. Se sustenta en una investigación realizada por la autora en el Observatorio de Drogas del Gobierno de la Ciudad Autónoma de Buenos Aires (GCABA): “Consumo de sustancias  en niños de calle”. El objetivo del estudio de carácter cualitativo se basa en datos recogidos en cincuenta entrevista a niños de calle sobre el consumo de drogas, su funcionalidad y la valoración que los niños hacen del mismo.
IN MEMORIAM PROFESOR MARIO SILVA GARCÍA
Authors: Lapoujade María Noel
Published: August 2021

"Pinto este retrato con algunos rasgos salientes del pensamiento, afinidades electivas y vida que encuentro en un rápido recorrido por la historia de la filosofía". María Noel Lapoujade
Pengaruh motivasi dan kompetensi terhadap kinerja dosen tetap di sekolah tinggi pariwisata bali internasional denpasar
Authors: Gariyasa Ni Made Christina
Published: August 2021

Kualitas akademik sebuah perguruan tinggi tidak lepas dari keberhasilannya menyelenggarakan Tri Dharma Perguruan Tinggi, yaitu Pendidikan, Penelitian dan Pengabdian Kepada Masyarakat. Perguruan Tinggi dituntut untuk terus mengembangkan tiga keunggulan, yaitu keunggulan dalam pendidikan, penelitian dan pengabdian kepada masyarakat terkait pemanfaatan dan penerapan ilmu pengetahuan, teknologi, dan seni (IPTEKS). Penelitian ini bertujuan untuk menganalisis efek motivasi dan kompetensi terhadap kinerja dosen tetap. Jumlah sampel dalam penelitian ini adalah 63 responden.  Teknik pengumpulan data dalam penelitian ini adalah kuesioner dan dokumentasi. Pengambilan sampel menggunakan teknik sensus, yaitu teknik pengambilan sampel yang dilakukan pada tujuan dan pertimbangan tertentu. Metode penelitian yang digunakan dalam penelitian ini adalah metode kuantitatif. Dalam analisis beberapa regresi linear yang diperoleh persamaan adalah Y = 4.048 + 0.204X1 + 0.238X2. Selain itu juga terbukti bahwa pengaruh motivasi terhadap kinerja Dosen Tetap di Sekolah Tinggi Pariwisata Bali Internasional merupakan efek positif dan signifikan, yang dibuktikan dengan adanya nilai probabilitas kurang dari 0,05 yaitu 0,04.  Sedangkan pengaruh kompetensi terhadap kinerja Dosen Tetap di Sekolah Tinggi Pariwisata Bali Internasional menunjukkan efek positif dan signifikan, yang dibuktikan dengan adanya nilai probabilitas yang lebih kecil dari 0,05 yaitu 0,008. Untuk pengaruh motivasi dan kompetensi terhadap kinerja dosen tetap di Sekolah Tinggi Pariwisata Bali Internasional sebesar 39,9%.
Earnings quality and the cost of debt for SMEs under severe information asymmetry
Authors: Fera Pietro , Salzillo Gianmarco
Published: August 2021

The banking system has undergone substantial changes that boosted the relevance of transaction-lending technologies and the role of financial reporting in the bank-firm relationship. Due to the growing emphasis on accounting data, this study investigates the impact of earnings quality on the cost of debt for a sample of SMEs during the global financial crisis. Relying on a sample of Italian non-financial SMEs, empirical findings show a positive relationship between discretionary accruals and the cost of loans, highlighting the negative consequences of low-quality earnings. Further analysis reveals the different impacts that negative and positive abnormal accruals can have on the cost of debt: low values of the former can convey private information and positively affect the response variable, which shows a positive and quadratic relationship with the latter. These findings confirm the increasing importance of hard information in credit markets and point out the significant impact of the quality of the borrowers’ earnings on the cost of debts. However, the distinctiveness of the study from the previous literature relies on evidence that, even during a credit crunch period, financial institutions weigh up the expected return from lending transactions, relying on both the sign and the magnitude of discretionary abnormal accruals as a vehicle to get firms’ private information.
Behcet’s Disease in an Adult Male From Nepal: A Case Report
Authors: Basnet Madan , Phudong Abisha , Gautam Kamal , Pathak Bishnu , Gaire Suman , Bohara Narayan , Srivastava Ayushi
Published: August 2021

Behcet’s Disease is a rare systemic vasculitis characterized by
recurrent episodes of acute inflammation affecting blood vessels of all
sizes. Symptoms include orogenital apthosis, cutaneous skin lesions, and
uveitis. We present the case of a 38-year-old Nepalese man with Behcet’s
Disease. In Nepal, Behcet’s Disease may still be under-reported.
Mevcut Yapı Cephelerinin Isıl Özelliklerinin Nicel Kızılötesi Isıl Görüntüleme Yöntemi ile Yerinde İncelenmesi
Authors: KOÇKAR TUĞLA Rukiye
Published: August 2021

Yapıların enerji perfomansı inşa edildikleri malzemelerin termofiziksel özellikleri ile ilişkilidir. Isıl atalet/termal efusivite bir malzemenin ısıl iletkenlik hesap değeri (λ, W/mK), özgül ısı değeri (c, J/kgK) ve yoğunluğuna (ρ, kg/m3) bağlı olan bir termofiziksel özelliktir. Termal athalet bir malzemenin ısıya karşı göstermiş olduğu ısıl davranış hakkında bilgi verir. Sıcaklık değişimi olan bir ortam etkisinde düşük termal ataletli bir malzemenin yüzey sıcaklığı çok hızlı değişirken, yüksek termal ataletli malzemenin yüzey sıcaklığı daha yavaş değişir. Bu çalışmada mevcut bir bina cephesinin ısınma davranışları nicel Kızılötesi Isıl Görüntüleme Yöntemi (KÖIG) ile incelenmiştir. Çalışma alanı olarak binanın batı (ÇA1) ve kuzey (ÇA2) cepheleri seçilmiştir. Çalışma, temmuz ayında, güneşli bir günde ve 07:00-19:30 saatleri arasında yapılmıştır. ÇA1 ve ÇA2 olarak kodlanan çalışma bölgelerinden çalışma saatleri boyunca saat başı ısıl görüntüler alınmış; çalışma alanlarının ısıl haritaları oluşturulmuştur. Alınan ısıl görüntüler yazılım programı sayesinde analiz edilmiş ve analiz sonucu elde edilen yüzey sıcaklık verileri ile sıcaklık farkı (ΔT), ısınma hızı (RW) ve ısınma hızı oranları (RWSORUN/ RWKONROL) gibi bazı ısıl parametreler hesaplanmıştır. Bu parametreler ile bina cephelerinde kullanılan malzemelerin ısınma davranışları incelenmiştir. Ayrıca çalışma alanlarında bulunan ısıl sorunlu bölgeler tespit edilmiş ve bu bölgeler de nicel verilerle değerlendirilmiştir. Çalışma sonucunda ısıl ataleti yüksek olan malzemelerin, düşük ısınma hızı verilerine sahip olduğu görülmüştür. Isınma hızı verileri ile aynı çalışma bölgesindeki (ÇA1) sorunlu alanın, sağlam/sorunsuz alana göre daha hızlı ısındığı tespit edilmiştir.
6 Serbestlik Derecesine Sahip 3-CCC Tipi Robot İçin İki Tasarım Önerisi ve Çalışma Uzayı Karşılaştırması
Authors: YILMAZ Savaş , KÜÇÜK Serdar , TOZ Metin
Published: August 2021

Bu çalışmada 6 serbestlik derecesine sahip 3D3A sınıfı paralel robot yapılarından 3-CCC tipi asimetrik paralel mekanizmanın ters kinematik analizleri yapılmış ve iki adet tasarım önerisinde bulunulmuştur. Önerilen tasarımların çalışma uzayları hesaplanmıştır. Tasarımlarda D_4 tipi kısıt ile sağlanan CPAC (P: Aktif prizmatik eklem) bacak yapısı ve A_1 tipi kısıt ile sağlanan CPAC (A: Aktif dönel eklem) bacak yapısı kullanılmıştır. Ayrıca tek bir bacakta iki aktif eklem kullanılarak elde edilen CPAC (A: Aktif dönel eklem, P: Aktif prizmatik eklem) bacak yapısı da tasarımlarda kullanılmıştır. Bu robot tipi literatürde 3-CCC mekanizma olarak da geçmektedir. İlk tasarım önerisinde sabit ve hareketli platformlar kenarları silindirik eklem olan eşkenar üçgenler olacak şekilde belirlenmişlerdir. Platformlar birbirine 3 adet CCC bacak tipiyle bağlanmıştır. İkinci tasarım önerisinde XY, XZ ve YZ düzlemlerine yerleştirilmiş olan sabit silindirik eklemler ile nokta uç işlevcisine sahip olan hareketli platform, 3 adet CCC bacak tipiyle bağlanmıştır. Sabit ve haraketli platformda kullanılan silindirik eklem uzunlukları iki tasarımda da aynı tutulmuştur. Çalışma uzayları hesaplanırken uç işlevcinin ulaşabileceği sınır noktaları belirlenerek içeride kalan bölge üzerinde 5 mm aralıklarla tarama yapılmış ve ulaşılabilirliği kontrol edilmiştir. Hareketli platform önce sabit 0o tutularak sonra -30o +30o açıları arasında döndürülerek çalışma uzayları hesaplanmıştır. Elde edilen sonuçlarla, farklı tasarımlar yapılarak çalışma uzayının genişletilebildiği görülmüştür.
International cooperation of S. I. Subbotin Institute Geophysics, NAS of Ukraine for 2010—2020
Authors: Starostenko V. I. , Rusakov O. M. , Yakimchik A. I.
Published: August 2021

The geological structure of the lithosphere of the main tectonic structures has been refined for the territory of Ukraine and adjacent regions of Slovakia, Poland, Romania, Russia, as well as Bulgaria, the Antarctic Peninsula (West Antarctica) and Southeast Asia, and new data have been obtained on geophysical impacts that can affect the environment. A geodynamic scenario has been developed for the formation of large-scale folding of the Fore- Dobrudzja Trough, the South Ukrainian monocline and the Ingul block of the Ukrainian Shield, caused by tectonic events associated with the closing of the Paleotethys and Neotethys oceans in the Mesozoic. In the Pripyat-Dnieper-Donets Basin, the structure of the earth’s crust and upper mantle can reflect different intensities of rifting, from its passive stage in the Dnieper Graben to active rifting in the Pripyat Trough. An analysis of the geoelectric structure of the Earth’s crust in the Ukrainian Eastern Carpathians indicates that seismic events occur mainly in resistive solid rock domainswhich surrounded by aseismic high conductive zones consisting of at least partially melted material. The present-day mutual position of the Ukrainian shield and Fennoscandia stabilized 1720—1660 Ma. The age, distribution, orientation and composition have been studied for the LatePalaeoproterozoicdykes in the Volyn, Ingul and Azov blocks of the Ukrainian Shield. Eastern Crimea and the Sorokin Trough are fragments of a tectonic wedge formed after the Paleocene. The geothermal conditions of the Intra-Carpathian region are due to subduction during the closure of the Pannonian sea basin and the collisional interaction of the Eurasian plate with the microplates system of this region. In Bulgaria, most earthquakes occur outside high-resistive domains. The tectonic stages are reconstructed for the formation of the northern part of the Antarctic Peninsula in the Mesozoic-Cenozoic. The relationship has been established between the geomagnetic field and climate change, with it being different for the Northern and Southern Hemispheres. The results have been obtained within the framework of 25 international projects and 6 temporary international target teams of S. I. Subbotin Institute of Geophysics, NAS of Ukraine consisting of researchers from 23 countries. The results are presented in 53 publications, 38 of which are indexed in the Web of Scienct database, and 32 papers are published in 20 international journals and special publications of 10 countries with different impact factors (from 0,101 to 4,214), whose average impact factor is 3,341, and the total one is 66,815.
Crime prevention in the field of computer technologies at the present stage in the Russian Federation: problems and ways to solve them
Authors: Alontseva Dina Viktorovna , Lavrishcheva Olga Anatolyevna
Published: August 2021

In the article, based on the analysis of existing approaches to the state and structure of computer crime in the Russian Federation, the authors formulated the concept of "computer crime", identified the key features of this type of crime; and also, based on the analysis of the causes and conditions of committing crimes in the field of high technologies, developed a set of special legal, ideological, managerial, organizational and forensic measures that are aimed at preventing and preventing computer crimes. Alontseva Dina Viktorovna; Lavrishcheva Olga Anatolyevna In the course of this research, the norms of international acts, domestic legislation, reports and statistics of law enforcement agencies of the Russian Federation and specialized organizations, materials of judicial practice were studied, as well as doctrinal sources on the topic of the work were analyzed. The authors used general methods of scientific cognition (dialectical, inductive, deductive), as well as private scientific methods used in the legal sciences-the method of comparative law and the formal legal method.
Вплив рівня свідомості та неврологічного дефіциту в дебюті субарахноїдально-го крововиливу на ранній вихід пацієнта
Authors: Цьома Є.І. , Смоланка В.І.
Published: August 2021

Вступ. У структурі цереброваскулярних захворювань геморагічний інсульт займає 20%, з яких 6–8% – це частка, що припадає на субарахноїдальний крововилив, внаслідок розриву артеріальних аневризм [1,3]. 10–15% субарахноїдальних крововиливів є фатальними, тобто пацієнти помирають ще до поступлення в медичний стаціонар [5]. Виявлення факторів, які впливають на перебіг цього захворювання та розвиток ускладнень дозволить покращити надання допомоги цим пацієнтам, створить можливість ідентифікувати групи пацієнтів для раннього чи відтермінованого оперативного втручання (кліпування аневризми) чи ендоваскулярного її закриття.
Мета. Проаналізувати всі випадки нетравматичного САК, у пацієнтів що перебували на лікуванні в ОКЦНН із січня 2013 р. по грудень 2016 р. та з’ясувати вплив рівня свідомості та фокального неврологічного дефіциту в дебюті захворювання, оціненого за валідизованими шкалами на ранній вихід пацієнтів.
Матеріали та методи. Проведено оцінку за валідизованими шкалами (HuntHess, WFNS та шкалою коми Глазго (GCS) та аналіз цих даних у 127 пацієнтів із субарахноїдальним крововиливом внаслідок розриву аневризми переднього півкільця артеріального кола головного мозку, що перебували на лікуванні в Обласному клінічному центрі нейрохірургії та неврології м. Ужгород за період з січня 2013 по грудень 2016 рік (включно).
Результати досліджень та їх обговорення. Провівши статистичний аналіз у досліджуваних групах, ми виявили, що вищий бал за шкалами HuntHess, WFNS та шкалою коми Глазго (GCS) в дебюті САК є достовірним предиктором доброго раннього виходу, тоді як рівень III–V асоціювався з високою смертністю (p<0.001). Достовірної різниці між чутливістю шкал щодо прогнозу при САК нами не знайдено. Дані, визначені за допомогою всіх цих шкал мали тісний кореляційний з’язок зі шкалою GOS, що свідчить про їх прямий вплив на показник раннього виходу після САК.
Висновки. Таким чином, аналізуючи наші дані, можемо стверджувати, що клінічні шкали, є високочутливим інструментом у прогнозуванні раннього перебігу САК, що співпадає з даними літератури і внесено в рекомендації ведення пацієнтів такого профілю. Рівень IV за HuntHess та IV–V за WFNS, а також нижчий рівень свідомості при поступленні в стаціонар за Glasgow Coma Scale – мають вкрай несприятливий прогноз.
Ключові слова: субарахноїдальний крововилив (САК), мішковидна аневризма, комп’ютерна томографія, World Federation Neurosergical Society Scale (WFNS), Glasgow Coma Scale (GCS), HuntHess Scale, Glasgow Outcome Scale (GOS).
Фотоспектрометричне дослідження структури поверхневого шару матеріалів АСЗ-5 та FAR 5 після витримки in vivo
Authors: Шимон В.М. , Алфелдій С.П. , Стойка В.В. , Шерегій А.А. , Шимон М.В.
Published: August 2021

Механізм скріплення кісткової тканини з матеріалом аналогічний механізму природного ремоделювання кістки. Після імплантації біоактивних матеріалів жива кістка формує міцний фізико-хімічний зв’язок з імплантатом, який повинен характеризуватися значною стабільністю проти хімічного і біологічного руйнування під дією рідкого середовища людського організму, оскільки призначений для постійного знаходження усередині людського тіла.
Мета дослідження: на основі експериментальних і теоретичних досліджень електронної будови апатитів природного походження встановити механізм взаємодії АСЗ-3 та FAR 5 з органічним матриксом нативної кістки і зародкоутворення апатиту in vivo.
Матеріали та методи. Хімічний склад поверхневих шарів та їх структуру визначали кількісним методом електроного зондового мікроаналізу на скануючому електроному мікроскопі РЭМ Tescan Mira 3LMU з використанням енергодисперсійного спектрометру Oxford X-max 80mm.
Результати досліджень та їх обговорення. Результати дослідження поперечного перерізу склокристалічного матеріалу FAR 5, який було імплантовано в кісткову тканину, дозволили встановити таке: після 14 та 28 витримки in vivo в умовах статичних та динамічних навантажень імплантат щільно прилягає до кісткової тканини, що свідчить про цілісність формування зв’язку імплантат – кісткова тканина. Структура імплантату після динамічних навантажень не втрачає міцності: не містить тріщин і зломів та наявності дебрису. Це вказує на відповідність пружних та механічних властивостей до таких як у кісткової тканини.
При поперечному перерізі зразку АСЗ-5, який імплантовано у кісткову тканину, через 14 діб in vivo cпостерігається його міцна фіксація у зоні контакту. Після 28 діб in vivo зразок АСЗ-5 характеризується незначними зламами поверхні, що свідчить про його крихкість. Це може обумовити складність вилучення імплантату при повторних операціях. Однак завдяки тому, що даний зразок характеризується здатністю до прискореного формування апатитоподібного шару впродовж одного місяця, процес мінералізації даного імплантату дозволить забезпечити його міцність впродовж експлуатації.
Висновки. Встановлено, що природні апатити характеризуються наявністю великої кількості дефектів у їх структурі. Мінералізація нанодисперсних кристалів кістки у відсутності умов формування апатиту з перебігом тривалого часу супроводжується деградацією кісткового мінералу.
Встановлені умови осадження кристалічних фаз АМФ та ОГА як прекурсорів для формування апатитового шару ГАП на поверхні імплантату in vivo, що є запорукою успішної адаптації імплантату в середовищі організму.
Ключові слова: кісткова тканина, біоскло, природні апатити.
Management of urinary incontinence in women with overactive bladder in urologist daily practice
Authors: Wiatr Tomasz , Chłosta Piotr
Published: August 2021

Urinary incontinence urinary incontinence is common among women and contributes to decreased quality of life. Several effective treatment options are available for the most common types of urinary incontinence (stress, urge, and mixed), including lifestyle modification and behavioral technique, drug therapy, and minimally invasive procedures. Most women improve with treatment, and urinary incontinence is not an inevitable part of aging. To maximize the opportunity for successful treatment, it is essential to align the therapeutic approach with patient goals and expectations for care, including an assessment of patient-driven priorities regarding potential adverse effects, costs, and expected benefit of different treatment approaches. There are many unique challenges in treating an overactive bladder in older women, such as functional and cognitive impairment, multimorbidity, polypharmacy, and estrogen deficiency, all of which contribute to treating symptoms in older women. This review highlights the current understanding of age-related changes in bladder function and proposes specific clinical considerations for overactive bladder management specific to older women.
Motivation and Preferences of Human Resources in the Medical Field – Premises for Further Policies in the Medical Sector in Romania
Authors: Georgescu Mirela Cristina , Furtunescu Florentina Ligia , Frumusachi Otilia , Lopatica Lavinia , Mincă Dana Galieta
Published: August 2021

The health professionals might be driven by different reasons in choosing their future medical specialty like passion, personal interest, balance with the family life, financial expectation, prestige etc. Our study aimed to explore the dominant preferences of the medical students in choosing their medical specialty in relation to their personal profile. We analysed the options of 3424 students from three cohorts the biggest public medical university of Romania. We found that most of the medical student are very career oriented, with low interest in having a family or children during their student life, most are income-dependent by others, and driven by passion/interest in choosing their future specialty, but with low interest for family medicine. Our data could be relevant for the policy makers for tailoring the long-term human resources polices adapted to the students’ values, with the aim to assure an equitable coverage with medical services all over the country.
Tuberculosis and Covid-19 Co-Infection – Clinical Characteristics
Authors: Rădulescu Adriana
Published: August 2021

The threat of contagious infectious diseases is constantly evolving as demographic explosion, travel globalization and changes in human lifestyle increase the risk of speeding pathogens, leading to accelerate changes in disease landscape.(1) Tuberculosis and Covid-19 are both infectious diseases that attack primarily the lungs. Both diseases have similar symptoms such as cough, fever and difficulty breathing. Tuberculosis has a longer incubation period with a slower reset of disease. Experience on Covid-19 infection in TB patient remains limited. 8 studies reported a total of 80 patients with this co-infection. These patients were reported from 9 different countries, with Italy reporting the largest number of cases.(2) The aim of this study is to evaluate the characteristic of TB and Covid-19 co-infection in 10 patients who were admitted in the Pulmonology Hospital of Sibiu between 01.05.2020-30.04.2021. All of these patients were with nosocomial infection Covid-19 and were previously diagnosed with TB.