bluuebunny/crossref_metadata_2025 huggingface dataset:
Choose Wisely! – Considering the Perceived Threat in the Selection of Trauma Film Clips May Improve the Ecological Validity of the Trauma Film Paradigm
Authors: Herzog Philipp , McNally Richard J.
Published: June 2024

Background

The trauma film paradigm (TFP) is the gold standard experimental psychopathology model of psychological trauma. However, different film clips with distinct effects on trauma-analogue symptoms are used across TFP studies, raising questions about the generalizability of study-specific results and the ecological validity of the TFP. Little is known about differences among film clips commonly used in the TFP regarding key features of psychological trauma (i.e., threat and anxiety) and their veridicality.

Methods

Thirty healthy participants watched eight trauma film clips in randomized order and subsequently rated each in view of perceived threat, anxiety, and realism. In addition to descriptive statistics, variance analyses and pairwise comparisons were performed to test for differences on these outcomes.

Results

The results indicated significant differences among the trauma film clips in terms of perceived threat and realism. However, nearly all trauma film clips evoked moderate anxiety levels.

Conclusions

This study stressed the importance of perceived threat as a key feature in selecting film clips for the TFP, as highly threatening film clips were also perceived as more realistic. When replicated using delayed outcomes (e.g., intrusive memories), choosing trauma film clips in view of their perceived threat might improve the ecological validity of the TFP.
Digital competence among 1st and 4th year primary education undergraduate students: a comparative study of face-to-face and on-line teaching
Authors: Cepa-Rodríguez Estíbaliz , Murgiondo Juan Etxeberria
Published: June 2024

Digital competence (DC) has become a key element for future teachers in the effort to guarantee a high-quality education system that responds to the needs of the 21st century. For this reason, numerous studies have tried to evaluate the DC of university students in education degrees, although very few have focused on the differences according to the academic year or the methodology used. This study aims to determine the level of DC among 1st and 4th year Primary Education undergraduates at two Spanish universities that employ different learning methods (face-to-face and online). The sample comprised 396 undergraduates who completed an online instrument (with a 10-point response scale) called the Higher Education Student Digital Competence Questionnaire (CDAES). The results reveal that students’ level of DC upon graduation is basic-intermediate and that the dimensions in which they are most proficient are ‘Digital Citizenship’ and ‘Innovation’. Despite this, however, the tasks performed to justify this level are basic. The results also indicate that students’ DC improves as they progress in their degree and that the online method seems to be more effective in promoting this particular competency. We can therefore conclude that tasks specially designed to improve DC are included in teacher training degrees, particularly in the case of online courses, although we are unable to determine which specific practices or methodologies foster better outcomes. To clarify this, new empirical approaches that focus on these aspects are required, along with specific improvement actions or initiatives adapted to the needs of each individual group.
Towards a New Criminal Offence of Intimate Intrusions
Authors: McGlynn Clare
Published: June 2024

This article suggests a new approach to tackling women’s experiences of harm and abuse, particularly online, namely a criminal law of ‘intimate intrusions’. It seeks to reinvigorate Betsy Stanko’s (1985) concept of intimate intrusions, developing it particularly in the context of the ever-increasing prevalence of online abuse against women and girls, as well as establishing how this conceptualisation might manifest in law reform. Intimate intrusions, it is argued, provides a valuable umbrella concept that may better encompass both the range and nature of existing harms, as well as, crucially, the yet-to-be-imagined modes of abuse. Further, in suggesting a new criminal offence of intimate intrusions, this article challenges the common process of piecemeal criminal law reform, with each new manifestation of abuse resulting in a specific offence tackling that specific behaviour. While such an approach provides new redress options, it remains limited. Following an examination of recent reforms in Northern Ireland, where three distinct new criminal offences were adopted covering downblousing, upskirting and cyberflashing, this article suggests that the concept of ‘intimate intrusions’ provides a better foundation for a new criminal offence and outlines its potential nature and scope.
BRG1 Deficiency Promotes Cardiomyocyte Inflammation and Apoptosis by Activating the cGAS-STING Signaling in Diabetic Cardiomyopathy
Authors: Chen Ziying , Lai Xiangmao , Li Jingxuan , Yuan Xun , Li Yilang , Zhang Xiaojing , Kang Zhanfang , Ouyang Zizhang , Zeng Jianwen , Hou Ning , Liu Xiaoping
Published: June 2024

Brahma-related gene 1 (BRG1) has been implicated in the repair of DNA double-strand breaks (DSBs). Downregulation of BRG1 impairs DSBs repair leading to accumulation of double-stranded DNA (dsDNA). Currently, the role of BRG1 in diabetic cardiomyopathy (DCM) has not been clarified. In this study, we aimed to explore the function and molecular by which BRG1 regulates DCM using mice and cell models. We found that BRG1 was downregulated in the cardiac tissues of DCM mice and in cardiomyocytes cultured with high glucose and palmitic acid (HG/PA), which was accompanied by accumulation of dsDNA and activation of the cyclic GMP-AMP synthase (cGAS)–stimulator of interferon genes (STING) signaling pathway. shRNA-mediated Brg1 knockdown aggravated DCM mice cardiac functions, enhanced dsDNA accumulation, cGAS-STING signaling activation, which induced inflammation and apoptosis. In addition, the results were further verified in HG/PA-treated primary neonatal rat cardiomyocytes (NRCMs). Overexpression of BRG1 in NRCMs yielded opposite results. Furthermore, a selective cGAS inhibitor RU.521 or STING inhibitor C-176 partially reversed the BRG1 knockdown-induced inflammation and apoptosis in vitro. In conclusion, our results demonstrate that BRG1 is downregulated during DCM in vivo and in vitro, resulting in cardiomyocyte inflammation and apoptosis due to dsDNA accumulation and cGAS-STING signaling activation. Therefore, targeting the BRG1-cGAS-STING pathway may represent a novel therapeutic strategy for improving cardiac function of patients with DCM.
Microstructure, hardness, electrical, and thermal conductivity of SZCN solder reinforced with TiO2 and ZrO2 nanoparticles fabricated by powder metallurgy method
Authors: Mousa M. M. , Mohammed Moustafa M. , El-Kady Omyma A. , Mohamed H. S.
Published: June 2024

The microstructure and characterization of Sn–Zn–Cu–Ni (SZCN) solder alloy reinforced with TiO2 and ZrO2 nanoparticles (NPs) synthesized by powder metallurgy were investigated. Sn, Zn, Cu and Ni metallic powders were mixed mechanical by 10:1 ball to powder ratio with 300 rpm speed for 2 h. Then 0.5 wt% from nano ZrO2 or TiO2 was mixed by the same parameters with the mixed metal powder. The morphologies and microstructures development during the fabrication process was investigated by X-ray diffractometer (XRD), optical microscope (OM), and scanning electron microscope (SEM) with energy dispersive X-ray spectrometry (EDX). The results reveal an improved distribution of TiO2 or ZrO2 NPs in the SZCN matrix solder, which resulted in an improvement in its density. The analyses of microstructural demonstrated that the addition of TiO2 or ZrO2 NPs to SZCN solder results in the grain refinement of the β-Sn phase, besides the formation of Ni3Sn IMC with small size and uniform distribution. The microhardness was enhanced as a result of the addition of TiO2 or ZrO2 NPs. The experimental results showed that the SZCN-ZrO2 composite solder had the greatest hardness and stress exponent values due to its effectiveness in suppressing the growth of β-Sn grains and the pile-up of dislocations. Both the electrical and thermal conductivities were improved by incorporating TiO2 NPs compared to other solders.
Lifestyle Dimensions of Public Safety Personnel Families: There’s No Life Like It
Authors: Cramm Heidi , Cox Marilyn , Norris Deborah , Reid Nathalie , Tam-Seto Linna , Dekel Rachel , Fear Nicola T. , Delaney Lisa , Richmond Rachel , Mahar Alyson
Published: June 2024

Purpose

The nature and cumulative occupational demands imposed on families of public safety personnel (PSP) are substantial, in many cases non-negotiable, and distinct from the general population accentuating risk factors for family well-being. Despite this reality, the contributions of PSP families are not well understood, and a conceptual framework is needed. The aim of this paper is to summarize contextual factors (lifestyle dimensions) that shape the lives of PSP families; factors supported in the existing, albeit limited, body of research.

Methods

Grounded in the interpretive/constructivist paradigm, a synthesis was central to understanding the lived experiences of PSP families. An interdisciplinary research team engaged in an iterative process of framework analysis to capture the variability and complexity of PSP family life and distilled the overarching lifestyle dimensions.

Results

Three lifestyle dimensions—logistics, risks, and identities—emerged from contextual factors and represent distinct aspects of PSP family life. PSP families play a crucial role in that their capacity to accommodate the lifestyle dimensions (i.e., logistics, risks, and identities), without which the PSP could not meet the demands of the profession.

Conclusion

Promoting awareness of these dimensions and their consequent demands underscores the cumulative demands that put PSP families at risk. Responses from governments, public safety organizations, and communities are required to help PSP families manage non-negotiable elements of the public safety occupation that spill over into family life over which they have no control.
Measurement of Spiritual Wellbeing in an Australian Hospital Population Using the Functional Assessment of Chronic Illness Therapy: Spiritual Wellbeing Scale (FACIT-Sp-12)
Authors: Best Megan C. , Simpson Grahame , Jones Kate F. , Merritt Frankie , Casey Michael , Lynch Sandra , Eisman John A. , Cohen Jeffrey , Mackie Darryl , Beilharz Kirsty , Kearney Matthew
Published: June 2024

Spiritual wellbeing is known to be a predictor of increased patient coping in hospital settings. Therefore, access to a valid and reliable measure of spiritual wellbeing amongst general hospital patients is highly recommended. The aim of this study was to investigate the dimensionality, reliability, and validity of the Functional Assessment of Chronic Illness Therapy Spiritual Wellbeing scale (FACIT-Sp-12) in a heterogeneous cohort of hospital patients. A cross-sectional survey was administered to 897 adult patients across six hospitals in Sydney, Australia. Confirmatory factor analysis for the three-factor FACIT-12-Sp indicated a poor fit, but after removal of Item 12, the three-factor FACIT-11-Sp presented a good fit to the data. Reliability testing indicated acceptable to good internal consistency. Validity was supported by statistically significant differences between patients who considered themselves ‘both spiritual and religious’ and ‘not religious or spiritual’. While some caution should be taken when using the FACIT-Sp due to several limitations, nevertheless, in a general hospital population in Australia, the three-factor FACIT-11-Sp indicated good dimensionality, reliability, and validity.
Preparation of radiation-sensitive dosimeter for gamma rays
Authors: Gafar S. M. , El-Tokhy H. H.
Published: June 2024

This research uses two different dosimetry techniques (films and gels) to evaluate how γ-rays affect Cyanidin chloride. The first method relies on combining CC with poly (vinyl alcohol) to create a thin film dosimeter, while the second uses CC with gelatin to create a gel dosimeter that is more sensitive to γ-rays. The produced film or gel changes visually from red to colorless when exposed to γ-rays. The usable dose range of films was up to 35 kGy, and for gels, it was between 10 and 150 Gy. All dosimetric characteristics were studied.
Deontology and safe artificial intelligence
Authors: D’Alessandro William
Published: June 2024

The field of AI safety aims to prevent increasingly capable artificially intelligent systems from causing humans harm. Research on moral alignment is widely thought to offer a promising safety strategy: if we can equip AI systems with appropriate ethical rules, according to this line of thought, they’ll be unlikely to disempower, destroy or otherwise seriously harm us. Deontological morality looks like a particularly attractive candidate for an alignment target, given its popularity, relative technical tractability and commitment to harm-avoidance principles. I argue that the connection between moral alignment and safe behavior is more tenuous than many have hoped. In general, AI systems can possess either of these properties in the absence of the other, and we should favor safety when the two conflict. In particular, advanced AI systems governed by standard versions of deontology need not be especially safe.
The effect of time since last fire occurrence on selected soil hydrological properties in a South African savanna
Authors: Strydom Tercia , Smit Izak P.J. , van Tol Johan J.
Published: June 2024

Background

Fires are a natural occurrence in African savannas yet little is known about how fires affect soil hydrological properties over time. This study aimed to determine the short-term (1–9 months post fire) and long-term (> seven decades fire exclusion) impact of experimental fires on soil hydrology in a fire-prone African savanna. This study also investigated how soil hydrological properties may vary under different vegetation physiognomies.

Methods

Saturated hydraulic conductivity (K) was determined using a modified falling head method through macropores (KMacro) while unsaturated K was measured using a tension disc infiltrometer (Ψ = 30 mm) to reflect the meso- and micro-pore conductivity (KMeso+Micro). Soil hydrophobicity was measured using the water droplet penetration time (WDPT) test.

Results

For the finer soil pores, fires significantly reduce KMeso+Micro in the short-term one month post-burn but returns to Pre-burn KMeso+Micro rates nine months later. After decades of fire suppression, KMacro is significantly faster compared to burned soils while KMeso+Micro was significantly slower through smaller pores compared to soils burned annually. KMeso+Micro is slowest under shrubs in fire suppression plots compared to other vegetation physiognomies. Fires did not induce hydrophobicity in the short-term nor the long-term.

Conclusion

Whilst fire reduces KMeso+Micro in the short-term, soils recovered nine months later, indicating that prescribed burning does not lead to lasting detrimental impacts on soil hydrological properties. Interestingly, decades of active fire suppression had either a positive or negative effect on the soil’s ability to allow water to infiltrate through the soil surface depending on the pore size and possible susceptibility to bioclogging and biocrusts.
Present records of the Past Hypothesis
Authors: Stradis Athamos
Published: June 2024

A striking feature of our world is that we only seem to have records of the past. To explain this ‘record asymmetry’, Albert and Loewer claim that the Past Hypothesis induces a narrow probability density over the world’s possible past macrohistories, but not its future macrohistories. Because we’re indirectly acquainted with this low-entropy initial macrostate, our observations of records allow us to exploit the associated narrow density to infer the past. I will argue that Albert and Loewer cannot make sense of why this probabilistic structure exists without falling back on the very records they wish to explain. To avoid this circularity, I offer an alternative account: the ‘fork asymmetry’ explains the record asymmetry, and this in turn explains the narrow density—not vice versa.
Mask vs. tent: effect of hypoxia method on repeated sprint ability and physiological parameters in cyclists
Authors: Vasquez-Bonilla Aldo A. , Rojas-Valverde Daniel , Feliu-Ilvonen Joan M. , Timón Rafael , Olcina Guillermo
Published: June 2024

This study aimed to evaluate the effect of repeated sprint in hypoxia (RSH) training in mask vs. tent system on the physiological parameters associated with the cyclist’s performance. Sixteen well-trained cyclists (VO2max 66 ± 5.9 mL/kg/min) participated in a randomised and two parallel groups design. Participants were assigned to different hypoxia methods [RSHMask (n = 8) vs RSHTent (n = 8)]. The sprint number and power output were measured during a repeated sprint test to failure before and after the effect of eight sessions of RSH. In addition, the following physiological parameters were evaluated: oxygen consumption (VO2), heart rate (HR), arterial oxygen saturation (SpO2), muscle oxygen saturation (SmO2), lactate and core temperature (CoreT°). Linear mixed models were used for repeated measures (p value < 0.05), and the effect size (ES) between groups was reported. An inter-individual analysis of participants was also reported. There was an increase in sprint numbers in both groups (ES = 0.167, p = 0.023) and an increase in power output (∑w) in the RSHMask group (ES = 0.095, p = 0.038). The RSHMask group showed improvement in VO2 recovery (ES = 0.096, p = 0.031) and SmO2 desaturation % (ES = 0.112, p = 0.042) compared to the RSHTent group. Likewise, 50% of the participants in RSHTent showed adaptations to withstand higher T°Core (+ 0.45°), and eight participants showed lactate decreases between 2.9 and 3.1 mmol/L (−24%) after RSH in both groups. Generally, RSH improves the cyclist’s performance, whether the mask or tent method is used. However, RSHTent has the advantage of causing adaptations in T°Core, whilst RSHMask improves anaerobic performance in the oxygenation of peripheral muscles.
The Difference a Three-Minute Video Makes: Presence(s), Satisfaction, and Instructor-Confidence in Post-Pandemic Online Teacher Education
Authors: Ingram Karen , Oyarzun Beth , Maxwell Daniel , Salas Spencer
Published: June 2024

Some research has shown that using videos in online courses can promote learner’s connection to the instructor (Banerjee et al., 2020). This quasi-experimental self-study aimed to explore the impact of brief three-minute instructor-generated videos in twin segments of an online graduate teacher education seminar focused on Globalization, Communities, and Schools. Specifically, we sought to understand the extent to which the insertion of these videos influenced teacher candidates’ perceptions of the dynamics of a Community of Inquiry (CoI) and their overall satisfaction as learners. The quantitative analysis of survey data using T-tests showed no statistically significant difference in overall learner satisfaction, social presence, teaching presence, or instructor social presence between the course with and without videos. However, there were significant differences in several individual items within each survey instrument. Student interviews and course evaluation comments were examined for themes revealing the strong presence of the instructor in various ways such as personalized feedback and caring tone. These findings suggest that while the videos may not have a significant impact on overall satisfaction, they do contribute to a more personalized and caring learning environment. Follow-up discussions with the instructor also revealed the reluctance to include short videos was grounded in his fear of inadvertently compromising the accessibility standards he wanted to honor–suggesting a continued need for growth in online instructors’ digital competencies and additional research into the perceived obstacles of expanding modalities of online graduate teacher education.
Automated hepatic steatosis assessment on dual-energy CT-derived virtual non-contrast images through fully-automated 3D organ segmentation
Authors: Jeon Sun Kyung , Joo Ijin , Park Junghoan , Yoo Jeongin
Published: June 2024

Purpose

To evaluate the efficacy of volumetric CT attenuation-based parameters obtained through automated 3D organ segmentation on virtual non-contrast (VNC) images from dual-energy CT (DECT) for assessing hepatic steatosis.

Materials and methods

This retrospective study included living liver donor candidates having liver DECT and MRI-determined proton density fat fraction (PDFF) assessments. Employing a 3D deep learning algorithm, the liver and spleen were automatically segmented from VNC images (derived from contrast-enhanced DECT scans) and true non-contrast (TNC) images, respectively. Mean volumetric CT attenuation values of each segmented liver (L) and spleen (S) were measured, allowing for liver attenuation index (LAI) calculation, defined as L minus S. Agreements of VNC and TNC parameters for hepatic steatosis, i.e., L and LAI, were assessed using intraclass correlation coefficients (ICC). Correlations between VNC parameters and MRI-PDFF values were assessed using the Pearson’s correlation coefficient. Their performance to identify MRI-PDFF ≥ 5% and ≥ 10% was evaluated using receiver operating characteristic (ROC) curve analysis.

Results

Of 252 participants, 56 (22.2%) and 16 (6.3%) had hepatic steatosis with MRI-PDFF ≥ 5% and ≥ 10%, respectively. LVNC and LAIVNC showed excellent agreement with LTNC and LAITNC (ICC = 0.957 and 0.968) and significant correlations with MRI-PDFF values (r = − 0.585 and − 0.588, Ps < 0.001). LVNC and LAIVNC exhibited areas under the ROC curve of 0.795 and 0.806 for MRI-PDFF ≥ 5%; and 0.916 and 0.932, for MRI-PDFF ≥ 10%, respectively.

Conclusion

Volumetric CT attenuation-based parameters from VNC images generated by DECT, via automated 3D segmentation of the liver and spleen, have potential for opportunistic hepatic steatosis screening, as an alternative to TNC images.
Effect of Load Ratio on Fatigue Crack Growth Behavior of SS316LN using Two-Parameter (ΔK and Kmax) Model
Authors: Duraipandi R. , Babu M. Nani , Moitra A.
Published: June 2024

Fatigue crack growth (FCG) behavior of SS316L (N) with 0.12 wt.% nitrogen has been studied with different load ratios at 300 K and 823 K in Paris and the threshold region. It is observed that, with increasing load ratio, the crack growth rate (da/dN) increases, and the threshold value (ΔKth) decreases. The variation in the ΔKth value with load ratio is generally attributed to the crack closure effects. Nevertheless, uncertainty exists in the consistent measurement of crack closure quantification. The present study aimed to develop a master curve using the two parametric concepts without invoking the crack closure approach. Attempts have been made to develop an FCG master curve using two-parameter models of Walker (ΔKw) and Kujawski (K*). The Kujawski (K*) model is found to merge the FCG data into a single master curve for the entire range of load ratios compared to the Walker model. Thus, the Kujawski (K*) model was found to be appropriate for life prediction analysis. However, two adjustable fitting parameters are required to get a single curve in this study since the two kinds of crack growth mechanisms are operative over the tested load ratio range. As revealed by the fractographic examination, the crack growth occurred by a faceted mode at lower load ratios for the tested temperature (300 K and 823 K) and the sustained load fracture is also observed at the higher (R = 0.7) load ratio, which comes through the Kmax.
Grafting based DNA methylation alteration of snoRNAs in upland cotton (Gossypium L.)
Authors: Karaca Mehmet , Ince Ayse Gul
Published: June 2024

The effects of grafting in response to various biotic and abiotic stressors have been studied, however, the methylation status of small nucleolar RNA (snoRNA) genes in heterograft and homograft cotton needs investigation. This study was undertaken to determine grafting effects on DNA methylation of snoRNA genes in Upland cotton. Rootstocks used were Pima 3–79 (Gossypium barbadense acc. Pima 3–79) and Texas Marker-1 (G. hirsutum acc. TM-1), representing two different species with different fiber properties, adaptations, and morphologies. The methylation ratio and differently methylated cytosines (DMCs) of 10935 snoRNA genes in mature seeds of heterograft and homograft cotton samples were studied using the whole genome bisulfite sequencing method. Seedling vigor and seed weight were studied to investigate phenotype alterations that might be associated with altered methylation levels among grafts. Statistically significant DMC differences among gene elements of snoRNA genes and between homograft and heterograft cotton samples were identified in the absence of DNA sequence alterations. DNA methylation alterations of snoRNA genes associated with seedling vigor and 100 seed weight. The majority of snoRNA genes showed higher numbers of mCG + mCHG-DMCs with increased methylation levels in heterograft, while there were higher numbers of mCG + mCHG-DMCs with decreased methylation levels in homograft. Since snoRNAs regulate essential genes for plant growth and development and plant adaptation to different habitats or extreme environments, their altered methylation levels should be related with plant physiology.
Coastal cultural ecosystem services and adolescents’ subjective well-being
Authors: Cabana David , Pinna Stefania , Farina Simone , Grech Daniele , Barbieri Nicholas , Guala Ivan
Published: June 2024

Despite growing recognition of nature’s impact on mental health, its specific effects on adolescents remain unclear. This gap hinders effective strategies for youth well-being in a world facing increasing environmental pressures. This study directly investigates the connections between coastal environments and subjective well-being in adolescents. We explore how interactions with coastal landscapes and associated cultural ecosystem services contribute to both personal and social dimensions of well-being in a sample of 202 adolescents (16 and 17 years old) from Sardinia, Italy. Our findings reveal a beneficial impact of coastal experiences, promoting positive affect, social integration, and physiological well-being. However, human pressures on these environments can lead to negative affect, while fostering a sense of social contribution. This research highlights the complex interplay between coastal environments, human impacts, and teenagers’ well-being. Understanding these links empowers planners to craft coastal management strategies that balance adolescents’ well-being with the long-term sustainability of coastal regions.
Investigation on Fracture Behavior of Electroslag Welding Joint with High-Performance Steel
Authors: Li Hongtao , Iyama Jun
Published: June 2024

This study aimed to investigate fracture behavior of electroslag welding (ESW) joint with 590-N/mm2 class steel using numerical analysis, covering a range of material scales in the structural level. The extended Mohr–Coulomb (EMC) fracture criterion was employed for finite element analysis (FEA). Uniaxial tensile test and three-point bending test were conducted to analyze the fracture behavior from the material scale and calibrate the fracture criterion. The test specimens consisted of the base metal, heat-affected-zone metal, and welding metal obtained from an ESW joint with a 590 N/mm2 class steel. Subsequently, FEA was conducted for a biaxial tensile test to investigate fracture behavior at a structural scale and verify the feasibility and accuracy of the calibrated fracture criterion. The comparison between the results from the FEA and test suggests that the FEA based on the EMC fracture criterion can accurately predict fracture behavior but tends to overestimate the bearing capacity. Thereafter, the effect of axial force on column was quantitatively investigated. The results suggest that the existence of tensile axial force at column decreases the ductility of ESW joint and shifts the fracture locus from the welding metal to heat-affected zone. However, the force has minimal influence on the pop-in load. Finally, the feasibility of applying the current Japanese specifications designated for the 490 N/mm2 class steel for the 590 N/mm2 class steel was examined. The results indicate that the provision can serve as a safe and reliable guideline for the 590 N/mm2 class steel as well.
A Prelude: From Slovak Mountains to Cognitive Biology
Authors: Tomáška Ľubomír , Neboháčová Martina
Published: June 2024

The main aim of this article is to provide a short overview of the research that gradually culminated in the concept of cognitive biology. To a certain extent it can be compared to a prelude: as the Merriam Webster dictionary defines it, “a musical section or movement introducing the theme or chief subject (as of a fugue or suite) or serving as an introduction to an opera or oratorio.” At first glance, this may seem to downplay the importance of the pre-cognitive biology period, but the opposite is true. Some preludes (consider, for example, La Traviata or Carmen) are as rich and beautiful as the acts that follow. We believe this is the case with the story culminating in the birth of cognitive biology, and we present it here in the form of an annotated (and somewhat virtual) interview with its leading actor, Ladislav Kováč.
A new method for individual treetop detection with low-resolution aerial laser scanned data
Authors: Diószegi Gergő , Molnár Vanda Éva , Nagy Loránd Attila , Enyedi Péter , Török Péter , Szabó Szilárd
Published: June 2024

In the past decade, the use of three-dimensional forest information from airborne Light Detection and Ranging (LiDAR) has become widespread in forest inventories. Accurate Individual Treetop Detection (ITD) and crown boundary delineation using LiDAR data are critical for obtaining precise inventory metrics. To address this need, we introduced a novel growing tree region (GTR)-driven ITD method that utilizes canopy height models (CHM) derived from very low-resolution airborne LiDAR data. The GTR algorithm consists of three key stages: (i) preserving all height layers through incremental cutting and stacking of CHM; (ii) employing a three-layer concept to identify individual treetops; and (iii) refining the detected treetops using a distance-based filter. Our method was tested in five temperate forests across Central Europe and was compared against the widely-used local maxima (LM) search combined with an optimized variable window filtering (VWF) technique. Our results showed that the GTR method outperformed LM with VWF, particularly in forests with high canopy density. The achieved root mean square accuracies were 74% for the matching rate, 19% for commission errors, and 27% for omission errors. In comparison, the LM with the VWF method resulted in a matching rate of 71%, commission errors of 20%, and omission errors of 31%. To facilitate the application of our algorithm, we developed an R package called TREETOPS, which seamlessly integrates with the lidR package, ensuring compatibility with existing treetop-based segmentation methods. By introducing TREETOPS, we provide the most accurate open-source tool for detecting treetops using low-resolution LiDAR-derived CHM.
Artificial Intelligence Needs Data: Challenges Accessing Italian Databases to Train AI
Authors: Staunton Ciara , Biasiotto Roberta , Tschigg Katharina , Mascalzoni Deborah
Published: June 2024

Population biobanks are an increasingly important infrastructure to support research and will be a much-needed resource in the delivery of personalised medicine. Artificial intelligence (AI) systems can process and cross-link very large amounts of data quickly and be used not only for improving research power but also for helping with complex diagnosis and prediction of diseases based on health profiles. AI, therefore, potentially has a critical role to play in personalised medicine, and biobanks can provide a lot of the necessary baseline data related to healthy populations that will enable the development of AI tools. To develop these tools, access to personal data, and in particular, sensitive data, is required. Such data could be accessed from biobanks. Biobanks are a valuable resource for research but accessing and using the data contained within such biobanks raise a host of legal, ethical, and social issues (ELSI). This includes the appropriate consent to manage the collection, storage, use, and sharing of samples and data, and appropriate governance models that provide oversight of secondary use of samples and data. Biobanks have developed new consent models and governance tools to enable access that address some of these ELSI-related issues. In this paper, we consider whether such governance frameworks can enable access to biobank data to develop AI. As Italy has one of the most restrictive regulatory frameworks on the use of genetic data in Europe, we examine the regulatory framework in Italy. We also look at the proposed changes under the European Health Data Space (EHDS). We conclude by arguing that currently, regulatory frameworks are misaligned and unless addressed, accessing data within Italian biobanks to train AI will be severely limited.
Delta-Beta Coupling in Adolescents With Depression
Authors: Venanzi Lisa , Dickey Lindsay , Pegg Samantha , Kujawa Autumn
Published: June 2024

Abstract: Cognitive behavioral therapy (CBT) is effective in treating adolescent depressive symptoms but with variable treatment responses. Heterogeneity in treatment outcomes may be due in part to individual differences in cognitive and emotional processes in depressed adolescents, and there is a need to identify biomarkers associated with symptoms and treatment outcomes. There has been growing interest in leveraging electroencephalography (EEG) data to examine correspondence between multiple frequency bands, and delta-beta coupling in particular is thought to underlie emotion regulation and offers a promising biomarker in adolescent depression. In the present study, clinically depressed adolescents aged 14–18 years old ( N = 54) completed 6 min of EEG at rest before and after a 16-session group CBT program. Analyses were focused on associations of pre- and posttreatment delta-beta coupling power with age, depressive symptoms, and clinician-rated severity at baseline and the end of treatment, and clinician-rated improvement. Results indicated that older adolescents showed lower delta-beta coupling than younger adolescents and girls showed higher coupling posttreatment. Greater delta-beta coupling before and after treatment was associated with greater clinician-rated severity. Surprisingly, greater pretreatment delta-beta coupling was associated with lower self-reported depressive symptoms with treatment. These results suggest that elevated delta-beta coupling, potentially reflecting more difficulty regulating emotions, is associated with gender and age in adolescents with depression and may be related to greater severity and poorer treatment outcomes, but replication in larger samples is needed.
Drivers of Seasonal Land‐Ice‐Flow Variability in the Antarctic Peninsula
Authors: Boxall Karla , Christie Frazer D. W. , Willis Ian C. , Wuite Jan , Nagler Thomas , Scheiblauer Stefan
Published: June 2024

Land‐ice flow in Antarctica has experienced multi‐annual acceleration in response to increased rates of ice thinning, ice‐shelf collapse and grounding‐line retreat. Superimposed upon this trend, recent observations have revealed that land‐ice flow in the Antarctic Peninsula exhibits seasonal velocity variability with distinct summertime speed‐ups. The mechanism, or mechanisms, responsible for driving this seasonality are unconstrained at present, yet detailed, process‐based understanding of such forcing will be important for accurately estimating Antarctica's future contributions to sea level. Here, we perform time‐series analysis on an array of remotely sensed, modeled and reanalysis data sets to examine the influence of potential drivers of ice‐flow seasonality in the Antarctic Peninsula. We show that both meltwater presence and ocean temperature act as statistically significant precursors to summertime ice‐flow acceleration, although each elicits an ice‐velocity response after a distinct lag, with the former prompting a more immediate response. Furthermore, we find that the timing and magnitude of these local drivers are influenced by large‐scale climate phenomena, namely the Amundsen Sea Low and the El Niño Southern Oscillation, with the latter initiating an anomalous wintertime ice‐flow acceleration event in 2016. This hitherto unidentified link between seasonal ice flow and large‐scale climatic forcing may have important implications for ice discharge at and beyond the Antarctic Peninsula in the future, depending upon how the magnitude, frequency and duration of such climate phenomena evolve in a warming world.
Expecting the Unexpected Could Help Us Prepare for Climate Extremes
Authors: Sidder Aaron
Published: June 2024

A new paper argues that too little consideration of high-impact, low-likelihood events has left us unprepared for the worst of climate change.
From inside to outside: exploring extracellular antimicrobial histone-derived peptides as multi-talented molecules
Authors: Muñoz-Camargo Carolina , Cruz Juan C.
Published: June 2024

The emergence of bacterial resistance to antibiotics poses a global health threat, necessitating innovative solutions. The contemporary challenge lies in bacterial resistance, impacting morbidity, mortality, and global economies. Antimicrobial peptides (AMPs) offer a promising avenue for addressing antibiotic resistance. The Antimicrobial Peptide Database catalogs 3569 peptides from various organisms, representing a rich resource for drug development. Histones, traditionally recognized for their role in nucleosome structures, have gained attention for their extracellular functions, including antimicrobial and immunomodulatory properties. This review aims to thoroughly investigate antimicrobial peptides derived from histones in various organisms, elucidating their mechanisms. In addition, it gives us clues about how extracellular histones might be used in drug delivery systems to fight bacterial infections. This comprehensive analysis emphasizes the importance of histone-derived peptides in developing innovative therapeutic strategies for evolving bacterial challenges.
An artificial intelligence-assisted microfluidic colorimetric wearable sensor system for monitoring of key tear biomarkers
Authors: Wang Zihu , Dong Yan , Sui Xiaoxiao , Shao Xingyan , Li Kangshuai , Zhang Hao , Xu Zhenyuan , Zhang Dongzhi
Published: June 2024

The precise, simultaneous, and rapid detection of essential biomarkers in human tears is imperative for monitoring both ocular and systemic health. The utilization of a wearable colorimetric biochemical sensor exhibits potential in achieving swift and concurrent detection of pivotal biomarkers in tears. Nevertheless, challenges arise in the collection, interpretation, and sharing of data from the colorimetric sensor, thereby restricting the practical implementation of this technology. To overcome these challenges, this research introduces an artificial intelligence-assisted wearable microfluidic colorimetric sensor system (AI-WMCS) for rapid, non-invasive, and simultaneous detection of key biomarkers in human tears, including vitamin C, H+(pH), Ca2+, and proteins. The sensor consists of a flexible microfluidic epidermal patch that collects tears and facilitates the colorimetric reaction, and a deep-learning neural network-based cloud server data analysis system (CSDAS) embedded in a smartphone enabling color data acquisition, interpretation, auto-correction, and display. To enhance accuracy, a well-trained multichannel convolutional recurrent neural network (CNN-GRU) corrects errors in the interpreted concentration data caused by varying pH and color temperature in different measurements. The test set determination coefficients (R2) of 1D-CNN-GRU for predicting pH and 3D-CNN-GRU for predicting the other three biomarkers were as high as 0.998 and 0.994, respectively. This correction significantly improves the accuracy of the predicted concentration, enabling accurate, simultaneous, and quick detection of four critical tear biomarkers using only minute amounts of tears ( ~ 20 μL). This research demonstrates the powerful integration of a flexible microfluidic colorimetric biosensor and deep-learning algorithm, which holds immense potential to revolutionize the fields of health monitoring.
An AS-OCT image dataset for deep learning-enabled segmentation and 3D reconstruction for keratitis
Authors: Sun Yiming , Maimaiti Nuliqiman , Xu Peifang , Jin Peng , Cai Jingxuan , Qian Guiping , Chen Pengjie , Xu Mingyu , Jia Gangyong , Wu Qing , Ye Juan
Published: June 2024

Infectious keratitis is among the major causes of global blindness. Anterior segment optical coherence tomography (AS-OCT) images allow the characterizing of cross-sectional structures in the cornea with keratitis thus revealing the severity of inflammation, and can also provide 360-degree information on anterior chambers. The development of image analysis methods for such cases, particularly deep learning methods, requires a large number of annotated images, but to date, there is no such open-access AS-OCT image repository. For this reason, this work provides a dataset containing a total of 1168 AS-OCT images of patients with keratitis, including 768 full-frame images (6 patients). Each image has associated segmentation labels for lesions and cornea, and also labels of iris for full-frame images. This study provides a great opportunity to advance the field of image analysis on AS-OCT images in both two-dimensional (2D) and three-dimensional (3D) and would aid in the development of artificial intelligence-based keratitis management.
Job-related exhaustion risk variant in UST is associated with dementia and DNA methylation
Authors: Sulkava Sonja , Haukka Jari , Kaivola Karri , Doagu Fatma , Lahtinen Alexandra , Kantojärvi Katri , Pärn Kalle , Palta Priit , Myllykangas Liisa , Sulkava Raimo , Laatikainen Tiina , Tienari Pentti J. , Paunio Tiina
Published: June 2024

Previous genome-wide association and replication study for job-related exhaustion indicated a risk variant, rs13219957 in the UST gene. Epidemiological studies suggest connection of stress-related conditions and dementia risk. Therefore, we first studied association of rs13219957 and register-based incident dementia using survival models in the Finnish National FINRISK study surveys (N = 26,693). The AA genotype of rs13219957 was significantly associated with 40% increased risk of all-cause dementia. Then we analysed the UST locus association with brain pathology in the Vantaa 85+ cohort and found association with tau pathology (Braak stage) but not with amyloid pathology. Finally, in the functional analyses, rs13219957 showed a highly significant association with two DNA methylation sites of UST, and UST expression. Thus, the results suggest a common risk variant for a stress-related condition and dementia. Mechanisms to mediate the connection may include differential DNA methylation and transcriptional regulation of UST.
Determinants of financial inclusion gaps in Pakistan and implications for achieving SDGs
Authors: Razzaq Amar , Qin Shengze , Zhou Yewang , Mahmood Irfan , Alnafissa Mohamad
Published: June 2024

This study investigates the determinants of gender disparities in financial inclusion in Pakistan using Global Findex 2021 survey data. We aim to quantify gender gaps in financial access and use, and to analyze the socio-economic factors influencing these disparities. Grounded in Sen’s capability approach and behavioral economics, we employ logistic regression to examine how gender influences the ownership and usage of financial products. Our results reveal significant gender gaps: only 13% of Pakistani women have financial accounts compared to 34% of men, with similar disparities in digital finance. Socio-economic variables like education, income, and employment are found to influence financial inclusion differently for men and women. While generally supportive of financial inclusion, these factors have a weaker effect for women, suggesting deeper societal barriers. This study adds to the global financial inclusion discourse by providing a comprehensive analysis of gender disparities in Pakistan. Our findings highlight the need for gender-sensitive policies that address these disparities to achieve Sustainable Development Goals related to gender equality and economic empowerment.
Effect of nanosilica on the hydrological properties of loess and the microscopic mechanism
Authors: Wang Li , Liu Qian , Li Xi-An , Qin Biao , Hong Bo , Shi Jianfeng
Published: June 2024

Loess areas, such as the Loess Plateau, are characterized by a fragile ecological environment, high soil erosion, and frequent geological disasters due to the unique hydrological properties of loess (e.g., collapsibility and permeability). Therefore, the loess must be stabilized for use in engineering construction. Traditional stabilizers (lime, cement, and fly ash) cause environmental problems, such as soil salinization and greenhouse gas emissions. Therefore, this study investigated the effect of nanosilica on the hydrological properties of loess and the microscopic mechanism. Different nanosilica contents (0.2%, 0.4%, 0.8%, 1%, and 3%) were added to loess sample, and the particle size distribution, Atterberg limits, collapsibility, and soil water characteristics were analyzed. The results revealed the following. The addition of nanosilica changed the particle size distribution, liquid limit, plastic limit, and plasticity index of loess. After the addition of nanosilica with different contents, the loess collapsibility coefficient curve shifted downward, the soil water retention curve shifted upward, and the unsaturated permeability coefficient curve shifted downward. The pores between particles were filled, and the number of large and medium pores and the pore connectivity were lower after the nanosilica addition. The surface of the coarse particles adsorbed more fine particles, and a large number of micro-aggregates or clay aggregates were present in the pores between particles. In conclusion, the environmentally friendly material nanosilica can be used to improve the hydrological properties of loess, which is applicable to alleviating soil erosion and preventing geological disasters on the Loess Plateau.