bluuebunny/crossref_metadata_2025 huggingface dataset:
Dispersion and Dosimetric Challenges of Hydrophobic Carbon-Based Nanoparticles in In Vitro Cellular Studies
Authors: Lizonova Denisa , Trivanovic Una , Demokritou Philip , Kelesidis Georgios A.
Published: March 2024

Methodologies across the dispersion preparation, characterization, and cellular dosimetry of hydrophilic nanoparticles (NPs) have been developed and used extensively in the field of nanotoxicology. However, hydrophobic NPs pose a challenge for dispersion in aqueous culture media using conventional methods that include sonication followed by mixing in the culture medium of interest and cellular dosimetry. In this study, a robust methodology for the preparation of stable dispersions of hydrophobic NPs for cellular studies is developed by introducing continuous energy over time via stirring in the culture medium followed by dispersion characterization and cellular dosimetry. The stirring energy and the presence of proteins in the culture medium result in the formation of a protein corona around the NPs, stabilizing their dispersion, which can be used for in vitro cellular studies. The identification of the optimal stirring time is crucial for achieving dispersion and stability. This is assessed through a comprehensive stability testing protocol employing dynamic light scattering to evaluate the particle size distribution stability and polydispersity. Additionally, the effective density of the NPs is obtained for the stable NP dispersions using the volumetric centrifugation method, while cellular dosimetry calculations are done using available cellular computational modeling, mirroring approaches used for hydrophilic NPs. The robustness of the proposed dispersion approach is showcased using a highly hydrophobic NP model (black carbon NPs) and two culture media, RPMI medium and SABM, that are widely used in cellular studies. The proposed approach for the dispersion of hydrophobic NPs results in stable dispersions in both culture media used here. The NP effective density of 1.03–1.07 g/cm3 measured here for black carbon NPs is close to the culture media density, resulting in slow deposition on the cells over time. So, the present methodology for dispersion and dosimetry of hydrophobic NPs is essential for the design of dose–response studies and overcoming the challenges imposed by slow particle deposition.
Advancements in Transparent Conductive Oxides for Photoelectrochemical Applications
Authors: Wen He , Weng Bo , Wang Bing , Xiao Wenbo , Liu Xiao , Wang Yiming , Zhang Menglong , Huang Haowei
Published: March 2024

Photoelectrochemical cells (PECs) are an important technology for converting solar energy, which has experienced rapid development in recent decades. Transparent conductive oxides (TCOs) are also gaining increasing attention due to their crucial role in PEC reactions. This review comprehensively delves into the significance of TCO materials in PEC devices. Starting from an in-depth analysis of various TCO materials, this review discusses the properties, fabrication techniques, and challenges associated with these TCO materials. Next, we highlight several cost-effective, simple, and environmentally friendly methods, such as element doping, plasma treatment, hot isostatic pressing, and carbon nanotube modification, to enhance the transparency and conductivity of TCO materials. Despite significant progress in the development of TCO materials for PEC applications, we at last point out that the future research should focus on enhancing transparency and conductivity, formulating advanced theories to understand structure–property relationships, and integrating multiple modification strategies to further improve the performance of TCO materials in PEC devices.
Understanding Lignin Dissolution with Urea and the Formation of a Lignin Nano-Aggregate: A Multiscale Approach
Authors: Lin Jinxin , Chen Liheng , Qin Yanlin , Qiu Xueqing
Published: March 2024

This study employs a combined computational and experimental approach to elucidate the mechanisms governing the interaction between lignin and urea, impacting lignin dissolution and subsequent aggregation behavior. Molecular dynamics (MD) simulations reveal how the urea concentration and temperature influence lignin conformation and interactions. Higher urea concentrations and temperatures promote lignin dispersion by disrupting intramolecular interactions and enhancing solvation. Density functional theory (DFT) calculations quantitatively assess the interaction energy between lignin and urea, supporting the findings from MD simulations. Anti-solvent precipitation demonstrates that increasing the urea concentration hinders the self-assembly of lignin nanoclusters. The findings provide valuable insights for optimizing lignin biorefinery processes by tailoring the urea concentration and temperature for efficient extraction and dispersion. Understanding the influence of urea on lignin behavior opens up avenues for designing novel lignin-based materials with tailored properties. This study highlights the potential for the synergetic application of MD simulations and DFT calculations to unravel complex material interactions at the atomic level.
Association of Combining Diet and Physical Activity on Sarcopenia and Obesity in Elderly Koreans with Diabetes
Authors: Kim Sohye , Kim Soojeong , Hong Kyung Hee
Published: March 2024

This study aimed to identify the combined factors of physical activity and diet associated with non-sarcopenic non-obese status in 1586 diabetic patients aged ≥65 years from the Korean National Health and Nutrition Examination Survey (2016 to 2019). Participants were categorized into non-sarcopenic non-obesity (NSNO), sarcopenia non-obesity (SNO), non-sarcopenic obesity (NSO), and sarcopenic obesity (SO) groups. NSNO had lower insulin, HOMA-IR, and triglycerides compared to NSO and SO. NSNO had lower perceived stress, higher nutrition education and dietary supplement intake. As assessed by the Korean Healthy Eating Index, NSNO scored higher total than SNO and SO, in breakfast and energy balance compared to SO, and in the adequacy of vegetables and meat/fish/egg/bean compared to SNO. NSNO had significantly higher energy and protein intake and physical activity, with BMI/waist circumference lower than NSO, SO, and comparable to SNO. Physical activity was positively associated with NSNO. Low Total KHEI score and protein intake level reduced the odds ratio (OR) of NSNO, particularly when physical activity was insufficient, with OR = 0.38 for KHEI Q1 and OR = 0.32 for protein T1. In conclusion, physical activity, diet quality, and protein intake are associated with NSNO prevalence in Korean elderly with diabetes, and energy balance through active intake and expenditure may be effective.
A Study of Fluid Intake, Hydration Status, and Body Composition of Pregnant Women in Their Third Trimester, and Relationships with Their Infant’s Birth Weight in China: A Prospective Cohort Study
Authors: Song Yongye , Zhang Fan , Wang Xing , Lin Guotian , He Limin , Lin Zhixiong , Zhang Na , Ma Guansheng
Published: March 2024

Background: Water intake and hydration status may potentially influence maternal and child health. However, there is little research regarding this topic. Objectives: This study aimed to investigate pregnant women’s total fluid intake (TFI) levels, hydration status, and body composition and further explore their relationship with infant birth weight. Methods: A 7-day, 24 h fluid intake recorded was applied to determine participants’ TFI levels. Morning urine samples were collected and tested to evaluate their hydration status. Maternal body compositions in their third trimester and infant birth weights were measured. Results: A total of 380 participants completed the study. The TFI was insufficient for pregnant women during their third trimester (median = 1574 mL), with only 12.1% of participants meeting the recommended adequate fluid intake level for pregnant women living in China (1.7 L per day). With the increasing TFI values, the urine osmolality decreased, which showed statistical significance among the four groups (χ2 = 22.637, p < 0.05). The participants displayed a poor hydration status. Meanwhile, the percentage of participants who were in dehydrated status decreased (χ2 = 67.618, p < 0.05), while body water content and basal metabolic rate increased with the increase in TFI levels (χ2 = 20.784, p < 0.05; χ2 = 14.026, p < 0.05). There were positive linear relationships between plain water intake, the basal metabolic rate of pregnant women and their infant birth weight (SE = 0.153, p < 0.05; SE = 0.076, p < 0.05). Conclusions: Water intake was insufficient, and poor hydration status was common among pregnant women in China. There may be potential relationships between plain water intake, basal metabolic rate, and infant birth weight.
Selenium Status of Southern Africa
Authors: Chilala Pompido , Skalickova Sylvie , Horky Pavel
Published: March 2024

Selenium is an essential trace element that exists in inorganic forms (selenite and selenates) and organic forms (selenoamino acids, seleno peptides, and selenoproteins). Selenium is known to aid in the function of the immune system for populations where human immunodeficiency virus (HIV) is endemic, as studies suggest that a lack of selenium is associated with a higher risk of mortality among those with HIV. In a recent study conducted in Zambia, adults had a median plasma selenium concentration of 0.27 μmol/L (IQR 0.14–0.43). Concentrations consistent with deficiency (<0.63 μmol/L) were found in 83% of adults. With these results, it can be clearly seen that selenium levels in Southern Africa should be investigated to ensure the good health of both livestock and humans. The recommended selenium dietary requirement of most domesticated livestock is 0.3 mg Se/kg, and in humans above 19 years, anRDA (recommended daily allowance) of 55 mcg Se/per dayisis recommended, but most of the research findings of Southern African countries have recorded low levels. With research findings showing alarming low levels of selenium in soils, humans, and raw feed materials in Southern Africa, further research will be vital in answering questions on how best to improve the selenium status of Southern African soils and plants for livestock and humans to attain sufficient quantities.
A Comparative Analysis between Whole Chinese Yam and Peeled Chinese Yam: Their Hypolipidemic Effects via Modulation of Gut Microbiome in High-Fat Diet-Fed Mice
Authors: Feng Qiqian , Lin Jinquan , Niu Zhitao , Wu Tong , Shen Qun , Hou Dianzhi , Zhou Sumei
Published: March 2024

Chinese yam is a “medicine food homology” food with medical properties, but little is known about its health benefits on hyperlipidemia. Furthermore, the effect of peeling processing on the efficacy of Chinese yam is still unclear. In this study, the improvement effects of whole Chinese yam (WY) and peeled Chinese yam (PY) on high-fat-diet (HFD)-induced hyperlipidemic mice were explored by evaluating the changes in physiological, biochemical, and histological parameters, and their modulatory effects on gut microbiota were further illustrated. The results show that both WY and PY could significantly attenuate the HFD-induced obesity phenotype, accompanied by the mitigative effect on epididymis adipose damage and hepatic tissue injury. Except for the ameliorative effect on TG, PY retained the beneficial effects of WY on hyperlipemia. Furthermore, 16S rRNA sequencing revealed that WY and PY reshaped the gut microbiota composition, especially the bloom of several beneficial bacterial strains (Akkermansia, Bifidobacterium, and Faecalibaculum) and the reduction in some HFD-dependent taxa (Mucispirillum, Coriobacteriaceae_UCG-002, and Candidatus_Saccharimonas). PICRUSt analysis showed that WY and PY could significantly regulate lipid transport and metabolism-related pathways. These findings suggest that Chinese yam can alleviate hyperlipidemia via the modulation of the gut microbiome, and peeling treatment had less of an effect on the lipid-lowering efficacy of yam.
Impact of Short-Term Creatine Supplementation on Muscular Performance among Breast Cancer Survivors
Authors: Parsowith Emily J. , Stock Matt S. , Kocuba Olivia , Schumpp Alec , Jackson Kylah , Brooks Alexander M. , Larson Alena , Dixon Madison , Fairman Ciaran M.
Published: March 2024

Breast cancer (BC) is one of the most common cancers in the United States. Advances in detection and treatment have resulted in an increased survival rate, meaning an increasing population experiencing declines in muscle mass and strength. Creatine supplementation has consistently demonstrated improvements in strength and muscle performance in older adults, though these findings have not been extended to cancer populations. PURPOSE: The purpose of this study was to investigate the effects of short-term creatine supplementation on muscular performance in BC survivors. METHODS: Using a double-blind, placebo-controlled, randomized design, 19 female BC survivors (mean ± SD age = 57.63 ± 10.77 years) were assigned to creatine (SUPP) (n = 9) or dextrose placebo (PLA) (n = 10) groups. The participants completed two familiarization sessions, then two test sessions, each separated by 7 days, where the participants supplemented with 5 g of SUPP or PLA 4 times/day between sessions. The testing sessions included sit-to-stand power, isometric/isokinetic peak torque, and upper/lower body strength via 10 repetition maximum (10RM) tests. The interaction between supplement (SUPP vs. PLA) and time (Pre vs. Post) was examined using a group × time ANOVA and effect sizes. RESULTS: No significant effects were observed for sit-to-stand power (p = 0.471; ηp2 = 0.031), peak torque at 60°/second (p = 0.533; ηp2 = 0.023), peak torque at 120°/second (p = 0.944; ηp2 < 0.001), isometric peak torque (p = 0.905; ηp2 < 0.001), 10RM chest press (p = 0.407; ηp2 = 0.041), and 10RM leg extension (p = 0.932; ηp2 < 0.001). However, a large effect size for time occurred for the 10RM chest press (ηp2 = 0.531) and leg extension (ηp2 = 0.422). CONCLUSION: Seven days of creatine supplementation does not influence muscular performance among BC survivors.
Brain-Derived Neurotrophic Factor as a Potential Mediator of the Beneficial Effects of Myo-Inositol Supplementation during Suckling in the Offspring of Gestational-Calorie-Restricted Rats
Authors: Valle Ana , Castillo Pedro , García-Rodríguez Adrián , Palou Andreu , Palou Mariona , Picó Catalina
Published: March 2024

This study aims to investigate the potential mechanisms underlying the protective effects of myo-inositol (MI) supplementation during suckling against the detrimental effects of fetal energy restriction described in animal studies, particularly focusing on the potential connections with BDNF signaling. Oral physiological doses of MI or the vehicle were given daily to the offspring of control (CON) and 25%-calorie-restricted (CR) pregnant rats during suckling. The animals were weaned and then fed a standard diet until 5 months of age, when the diet was switched to a Western diet until 7 months of age. At 25 days and 7 months of age, the plasma BDNF levels and mRNA expression were analyzed in the hypothalamus and three adipose tissue depots. MI supplementation, especially in the context of gestational calorie restriction, promoted BDNF secretion and signaling at a juvenile age and in adulthood, which was more evident in the male offspring of the CR dams than in females. Moreover, the CR animals supplemented with MI exhibited a stimulated anorexigenic signaling pathway in the hypothalamus, along with improved peripheral glucose management and enhanced browning capacity. These findings suggest a novel connection between MI supplementation during suckling, BDNF signaling, and metabolic programming, providing insights into the mechanisms underlying the beneficial effects of MI during lactation.
Nurses’ Roles in Caring for Older People in Domiciliary Settings: A Scoping Review Protocol
Authors: Santomauro Isabella , Bassi Erika , Durante Angela , Bracco Consolata , Busca Erica , Caristia Silvia , Dal Molin Alberto
Published: March 2024

Due to global shifts in demographics and advances in chronic illness management over the past few decades, domiciliary care has become the primary setting for caring for older people. In this regard, nurses play a crucial role, promoting quality care and minimizing hospital admissions and the need for institutionalization. However, historical and geographic variation in nursing titles and the multitude of labels for different roles have been obstacles to the creation of a clear map outlining specific nursing roles in home care for older people. The aim of this scoping review is to map the evidence on the different nurses’ roles in caring for older people in domiciliary settings. This review will include primary, secondary, and gray literature on nurses’ roles in domiciliary settings for older people, sourced through comprehensive searches of various databases (MEDLINE, Embase, CINAHL) and reference scanning. No language restrictions will be applied. Two independent reviewers will conduct screening and data extraction. The tabulated results will be informed by descriptive frequencies and content analysis, presenting comprehensive findings. The review protocol was retrospectively registered within OSF database on the 23 November 2023.
Delirium Diagnosis, Complication Recognition, and Treatment Knowledge among Nurses in an Italian Local Hospital: A Cross-Sectional Study
Authors: Ceccarelli Andrea , Ballarin Maddalena , Montalti Marco , Ceccarelli Paola , Mazzini Silvia , Minotti Alice , Gori Davide , Senni Marco
Published: March 2024

Delirium, a multifactorial condition with an acute onset and diverse clinical manifestations, poses a significant challenge in the care of hospitalized individuals aged 65 years and older. This study aimed to evaluate the level of knowledge among nursing healthcare personnel regarding the diagnosis, recognition of complications, and treatment of delirium. A paper questionnaire consisting of 18 multiple-choice questions was distributed to nurses in twelve operational units located in four facilities within a local hospital in a specific geographical region under the jurisdiction of the Romagna Local Health Authority in Italy. Out of 194 respondents, the overall acceptance rate was 64.2%. The findings revealed an insufficient understanding of delirium among the nursing staff, with more than 40% of respondents answering incorrectly to five out of nine questions related to delirium knowledge, diagnosis, prevention, and treatment. Notably, gender emerged as a significant determinant, with female participants exhibiting a substantial odds ratio (OR) of 3.50 (p = 0.011 and CI95% = 1.34–9.16) compared to their male counterparts, indicating a higher likelihood of receiving delirium training among females. Furthermore, prolonged tenure within the same work context was associated with a reduced likelihood of receiving delirium training compared to those with less than two years of experience (OR = 0.21, p = 0.034, and CI95% = 0.05–0.89 for 6–10 years of tenure; OR = 0.22, p = 0.038, and CI95% = 0.05–0.92 for over 10 years of tenure). This study underscores the urgent need for enhanced delirium education and improved strategies among nurses to effectively manage patients with delirium. The results advocate regular educational sessions utilizing diverse formats to comprehensively address knowledge gaps among nursing staff. This study was not registered.
Identification of Ureidocoumarin-Based Selective Discoidin Domain Receptor 1 (DDR1) Inhibitors via Drug Repurposing Approach, Biological Evaluation, and In Silico Studies
Authors: El-Damasy Ashraf K. , Kim Hyun Ji , Al-Karmalawy Ahmed A. , Alnajjar Radwan , Khalifa Mohamed M. , Bang Eun-Kyoung , Keum Gyochang
Published: March 2024

Discoidin domain receptor 1 (DDR1) kinase has emerged as a promising target for cancer therapy, and selective DDR1 inhibitors have shown promise as effective therapeutic candidates. Herein, we have identified the first coumarin-based selective DDR1 inhibitors via repurposing of a recent series of carbonic anhydrase inhibitors. Among these, ureidocoumarins 3a, 3i, and 3q showed the best DDR1 inhibitory activities. The m-trifluoromethoxy phenyl member 3q potently inhibited DDR1 with an IC50 of 191 nM, while it showed less inhibitory activity against DDR2 (IC50 = 5080 nM). 3q also exhibited favorable selectivity in a screening platform with 23 common off-target kinases, including BCR-ABL. In the cellular context, 3q showed moderate antiproliferative effects, while 3i, with the third rank in DDR1 inhibition, exerted the best anticancer activity with sub-micromolar GI50 values over certain DDR1-dependent cell lines. Molecular docking and MD simulations disclosed the putative binding mode of this coumarin chemotype and provided insights for further optimization of this scaffold. The present findings collectively supported the potential improvement of ureidocoumarins 3i and 3q for cancer treatment.
Potential Mechanism of Tibetan Medicine Liuwei Muxiang Pills against Colorectal Cancer: Network Pharmacology and Bioinformatics Analyses
Authors: Qi Shaochong , Liang Xinyu , Wang Zijing , Jin Haoran , Zou Liqun , Yang Jinlin
Published: March 2024

This study aimed to explore the mechanism through which Tibetan medicine Liuwei Muxiang (LWMX) pills acts against colorectal cancer (CRC). We firstly retrieved the active ingredients and the correlated targets of LWMX pills from public databases. The CRC-related targets were determined through bioinformatic analysis of a public CRC dataset. By computing the intersection of the drug-specific and disease-related targets, LWMX pill–CRC interaction networks were constructed using the protein–protein interaction (PPI) method and functional enrichment analysis. Subsequently, we determined the hub genes using machine learning tools and further verified their critical roles in CRC treatment via immune infiltration analysis and molecular docking studies. We identified 81 active ingredients in LWMX pills with 614 correlated targets, 1877 differentially expressed genes, and 9534 coexpression module genes related to CRC. A total of 5 target hub genes were identified among the 108 intersecting genes using machine learning algorithms. The immune infiltration analysis results suggested that LWMX pills could affect the CRC immune infiltration microenvironment by regulating the expression of the target hub genes. Finally, the molecular docking outcomes revealed stable binding affinity between all target hub proteins and the primary active ingredients of LWMX pills. Our findings illustrate the anti-CRC potential and the mechanism of action of LWMX pills and provide novel insights into multitarget medication for CRC treatment.
Influenza Virus Inactivated by Heavy Ion Beam Irradiation Stimulates Antigen-Specific Immune Responses
Authors: Schulze Kai , Weber Ulrich , Schuy Christoph , Durante Marco , Guzmán Carlos Alberto
Published: March 2024

The COVID-19 pandemic has made clear the need for effective and rapid vaccine development methods. Conventional inactivated virus vaccines, together with new technologies like vector and mRNA vaccines, were the first to be rolled out. However, the traditional methods used for virus inactivation can affect surface-exposed antigen, thereby reducing vaccine efficacy. Gamma rays have been used in the past to inactivate viruses. We recently proposed that high-energy heavy ions may be more suitable as an inactivation method because they increase the damage ratio between the viral nucleic acid and surface proteins. Here, we demonstrate that irradiation of the influenza virus using heavy ion beams constitutes a suitable method to develop effective vaccines, since immunization of mice by the intranasal route with the inactivated virus resulted in the stimulation of strong antigen-specific humoral and cellular immune responses.
Polysaccharides as a Hydrophilic Building Block of Amphiphilic Block Copolymers for the Conception of Nanocarriers
Authors: Lu Aijing , Li Suming
Published: March 2024

Polysaccharides are gaining increasing attention for their relevance in the production of sustainable materials. In the domain of biomaterials, polysaccharides play an important role as hydrophilic components in the design of amphiphilic block copolymers for the development of drug delivery systems, in particular nanocarriers due to their outstanding biocompatibility, biodegradability, and structural versatility. The presence of a reducing end in polysaccharide chains allows for the synthesis of polysaccharide-based block copolymers. Compared with polysaccharide-based graft copolymers, the structure of block copolymers can be more precisely controlled. In this review, the synthesis methods of polysaccharide-based amphiphilic block copolymers are discussed in detail, taking into consideration the structural characteristics of polysaccharides. Various synthetic approaches, including reductive amination, oxime ligation, and other chain-end modification reactions, are explored. This review also focuses on the advantages of polysaccharides as hydrophilic blocks in polymeric nanocarriers. The structure and unique properties of different polysaccharides such as cellulose, hyaluronic acid, chitosan, alginate, and dextran are described along with examples of their applications as hydrophilic segments in the synthesis of amphiphilic copolymers to construct nanocarriers for sustained drug delivery.
Optimizing Nanosuspension Drug Release and Wound Healing Using a Design of Experiments Approach: Improving the Drug Delivery Potential of NDH-4338 for Treating Chemical Burns
Authors: Roldan Tomas L. , Li Shike , Guillon Christophe , Heindel Ned D. , Laskin Jeffrey D. , Lee In Heon , Gao Dayuan , Sinko Patrick J.
Published: March 2024

NDH-4338 is a highly lipophilic prodrug comprising indomethacin and an acetylcholinesterase inhibitor. A design of experiments approach was used to synthesize, characterize, and evaluate the wound healing efficacy of optimized NDH-4338 nanosuspensions against nitrogen mustard-induced skin injury. Nanosuspensions were prepared by sonoprecipitation in the presence of a Vitamin E TPGS aqueous stabilizer solution. Critical processing parameters and material attributes were optimized to reduce particle size and determine the effect on dissolution rate and burn healing efficacy. The antisolvent/solvent ratio (A/S), dose concentration (DC), and drug/stabilizer ratio (D/S) were the critical sonoprecipitation factors that control particle size. These factors were subjected to a Box–Behnken design and response surface analysis, and model quality was assessed. Maximize desirability and simulation experiment optimization approaches were used to determine nanosuspension parameters with the smallest size and the lowest defect rate within the 10–50 nm specification limits. Optimized and unoptimized nanosuspensions were prepared and characterized. An established depilatory double-disc mouse model was used to evaluate the healing of nitrogen mustard-induced dermal injuries. Optimized nanosuspensions (A/S = 6.2, DC = 2% w/v, D/S = 2.8) achieved a particle size of 31.46 nm with a narrow size range (PDI = 0.110) and a reduced defect rate (42.2 to 6.1%). The optimized nanosuspensions were stable and re-dispersible, and they showed a ~45% increase in cumulative drug release and significant edema reduction in mice. Optimized NDH-4338 nanosuspensions were smaller with more uniform sizes that led to improved physical stability, faster dissolution, and enhanced burn healing efficacy compared to unoptimized nanosuspensions.
Design of a High-Gain and Tri-Band Terahertz Microstrip Antenna Using a Polyimide Rectangular Dielectric Column Photonic Band Gap Substrate
Authors: Li Gaofang , Huang Chenguang , Huang Renjie , Tang Bo , Huang Jingguo , Tan Jie , Xia Nenghong , Cui Haoyang
Published: March 2024

A high-gain and tri-band terahertz microstrip antenna with a photonic band gap (PBG) substrate is presented in this paper for terahertz communications. Polyimide dielectric columns are inserted into the silicon substrate to form the PBG substrate to improve the gain of the antenna. The PBG substrate and polyimide substrate constituted a multilayer substrate structure and enabled the multi-band operation of the antenna. The PBG substrate antenna achieves gains of 6.28 dB, 4.84 dB, and 7.66 dB at resonant frequencies of 0.360 THz, 0.580 THz, and 0.692 THz, respectively, outperforming the homogeneous substrate THz microstrip antenna (H antenna) by 1.18 dB, 1.74 dB, and 1.82 dB, respectively. The radiation efficiencies at three operating bands are over 93%, 92%, and 88%, respectively, which are slightly higher than that of the H antenna and greater than that of the standard multi-band antenna.
Exploration of Four-Channel Coherent Optical Chaotic Secure Communication with the Rate of 400 Gb/s Using Photonic Reservoir Computing Based on Quantum Dot Spin-VCSELs
Authors: Zhong Dongzhou , Wang Tiankai , Chen Yujun , Wu Qingfan , Qiu Chenghao , Zeng Hongen , Wang Youmeng , Xi Jiangtao
Published: March 2024

In this work, we present a novel four-channel coherent optical chaotic secure communication (COCSC) system, incorporating four simultaneous photonic reservoir computers in tandem with four coherent demodulation units. We employ a quartet of photonic reservoirs that capture the chaotic dynamics of four polarization components (PCs) emitted by a driving QD spin-VCSEL. These reservoirs are realized utilizing four PCs of a corresponding reservoir QD spin-VCSEL. Through these four concurrent photonic reservoir structures, we facilitate high-quality wideband-chaos synchronization across four pairs of PCs. Leveraging wideband chaos synchronization, our COCSC system boasts a substantial 4 × 100 GHz capacity. High-quality synchronization is pivotal for the precise demasking or decoding of four distinct signal types, QPSK, 4QAM, 8QAM and 16QAM, which are concealed within disparate chaotic PCs. After initial demodulation via correlation techniques and subsequent refinement through a variety of digital signal processing methods, we successfully reconstruct four unique baseband signals that conform to the QPSK, 4QAM, 8QAM and 16QAM specifications. Careful examination of the eye diagrams, bit error rates, and temporal trajectories of the coherently demodulated baseband signals indicates that each set of baseband signals is flawlessly retrieved. This is underscored by the pronounced eye openings in the eye diagrams and a negligible bit error rate for each channel of baseband signals. Our results suggest that delay-based optical reservoir computing employing a QD spin-VCSEL is a potent approach for achieving multi-channel coherent optical secure communication with optimal performance and enhanced security.
Shipwrecked on the Rock, or Not Quite: Gypsophytes and Edaphic Islands
Authors: Mota Juan F. , Martínez-Hernández Fabián , Pérez-García Francisco Javier , Mendoza-Fernández Antonio Jesús , Salmerón-Sánchez Esteban , Merlo M. Encarna
Published: March 2024

Species–area relationships (SAR) constitute a key aspect of ecological theory and are integral to other scientific disciplines, such as biogeography, which have played a crucial role in advancing biology. The theory of insular biogeography provides a clear example. This theory initially expanded from true islands to other types of systems characterized by their insularity. One such approach was linked to geoedaphic islands, as seen in gypsum outcrops. While these continental areas have been considered insular systems, only limited and mostly indirect evidence thereof has been provided. This study utilized SAR to advance the understanding of gypsum outcrops as insular continental territories. It is hereby hypothesized that gypsum outcrops are edaphic islands, although their insular nature depends on the different functional or ecological plant types, and this nature will be reflected in the potential Arrhenius model z values. The results obtained support both hypotheses and provide insight into the ecological factors that help interpret the insularity of these areas. This interpretation goes beyond their mere extent and the distance among outcrops, emphasizing the importance of environmental filters. Said filters vary in permeability depending on the degree of gypsophily, or preference for gypsum, exhibited by different species.
Enhancing Dental Material Performance: Tung Oil-Infused Polyurea Microcapsule Coatings for Self-Healing and Antimicrobial Applications
Authors: Zhong Jiaqiao , Hu Yuxiang , Wang Danqi , Zhou Xingxin , Yuan Peiyu , Luo Bowen , Li Yuanzhe
Published: March 2024

Within the realm of dental material innovation, this study pioneers the incorporation of tung oil into polyurea coatings, setting a new precedent for enhancing self-healing functionality and durability. Originating from an ancient practice, tung oil is distinguished by its outstanding water resistance and microbial barrier efficacy. By synergizing it with polyurea, we developed coatings that unite mechanical strength with biological compatibility. The study notably quantifies self-healing efficiency, highlighting the coatings’ exceptional capacity to mend physical damages and thwart microbial incursions. Findings confirm that tung oil markedly enhances the self-repair capabilities of polyurea, leading to improved wear resistance and the inhibition of microbial growth, particularly against Streptococcus mutans, a principal dental caries pathogen. These advancements not only signify a leap forward in dental material science but also suggest a potential redefinition of dental restorative practices aimed at prolonging the lifespan of restorations and optimizing patient outcomes. Although this study lays a substantial foundation for the utilization of natural oils in the development of medical-grade materials, it also identifies the critical need for comprehensive cytotoxicity assays. Such evaluations are essential to thoroughly assess the biocompatibility and the safety profile of these innovative materials for clinical application. Future research will concentrate on this aspect, ensuring that the safety and efficacy of the materials align with clinical expectations for dental restorations.
A New Approach of Complexing Polymers Used for the Removal of Cu2+ Ions
Authors: Marin Nicoleta Mirela
Published: March 2024

This study presents two modified polymers for Cu2+ ion removal from aqueous media. Shredded maize stalk (MC) and a strong-base anionic resin (SAX) were modified with indigo carmine (IC) in order to obtain two different complexing polymers, i.e., IC-MC and SAX-IC. Initially, the complex reaction between IC and Cu2+ in the solution was studied. Additionally, the complex formation Cu2+-IC in liquid solutions was evaluated at different pH ranges of 1.5, 4.0, 6.0, 8.0, and 10.0, respectively. For Cu2+ ions, adsorption onto the IC-MC and IC-SAX batch experiments were conducted. The contact time for evaluating the optimum adsorption for Cu2+ ions on the complexing materials was established at 1 h. Efficient Cu2+ ion adsorption on the IC-MC and SAX-IC at pH = 10 was achieved. The adsorption of Cu2+ ions depends on the quantity of IC retained on MC and SAX. At 2.63 mg IC/g MC(S4) and 22 mg IC/g SAX(SR2), a high amount of Cu2+ ion adsorption was reported. The highest adsorption capacity (Qe) of IC-MC was obtained at 0.73 mg/g, and for IC-SAX, it was attained at 10.8 mg/g. Reusability experiments were performed using the HCl (0.5 M) solution. High regeneration and reusability studies of IC-MC and IC-SAX were confirmed, suggesting that they can be used many times to remove Cu2+ ions from aqueous matrices. Therefore, the development of complexing materials could be suitable for Cu2+ ion removal from wastewater.
The Distribution Law of Ground Stress Field in Yingcheng Coal Mine Based on Rhino Surface Modeling
Authors: Tang Zhi , Wu Zhiwei , Jia Dunwei , Lv Jinguo
Published: March 2024

The distribution law of the ground stress field is of great significance in guiding the design of coal mine roadway alignment, determining the parameters of roadway support, and preventing and controlling the impact of ground pressure in coal mines. A geostress inversion method combining Rhino surface modeling and FLAC3D 6.0 numerical simulation software is proposed. Based on the geological data of the coal mine and the results of on-site measurements, a three-dimensional geological model of Yingcheng Coal Mine is established for the geostress inversion, and the distribution law of the geostress field in Yingcheng Coal Mine is obtained. Research shows the following: (1) The horizontal maximum principal stress values of the Yingcheng Mine are between 33.9 and 35.3 MPa, the horizontal minimum principal stress values are between 23.6 and 25.4 MPa, and the direction of the horizontal maximum principal stress is roughly in the southwest to west direction; (2) the three-way principal stress magnitude relationship is σH > σv > σh, indicating that the horizontal stress dominates in the study area, which belongs to the slip-type stress state; (3) The maximum principal stress of No. 3 coal seam is 33.1–34.8 MPa, the middle principal stress is 27.5–29.2 MPa, and the minimum principal stress is 17.3–22.9 MPa. Due to the influence of topography and burial depth, there is a phenomenon of stress concentration in some areas. By comparing the inversion values with the measured values, the accuracy of the geostress inversion is high, and the initial geostress inversion method based on Rhino surface modeling accurately inverts the geostress distribution pattern of the Yingcheng coal mine.
Novel Adsorbents for Environmental Remediation
Authors: Liu Yanju , Biswas Bhabananda , Naidu Ravi
Published: March 2024

Exposure to environmental pollution due to the contamination of soil, surface and groundwater, and air poses potential health risks to biotic and abiotic ecosystems [...]
An Experimental Investigation of Interaction between CO2 Solution and Rock under Reservoir Conditions in the Jimsar Shale Oil Formation
Authors: He Haibo , Ma Xinfang , Lei Fan , Liu Xinqiu , Jiang Ming , Li Yue , Mou Jianye
Published: March 2024

Chemical sequestration is one important manner of CCUS. The injection of CO2 into an oil reservoir can not only sequestrate CO2 but also raise the oil recovery factor. The performance of chemical sequestration of CO2 depends on the interaction between CO2 solution and reservoir rock. In this paper, we have conducted three different scales of experiments, e.g., microscopic scale, core scale, and time scale, to fully investigate the interaction and resultant variation to mineral content, microscopic structure, porosity, and permeability under reservoir conditions (i.e., reservoir temperature of 90 °C) in Jimusar shale oil formation. The microscopic-scale experiment applied SEM and hyperspectral scanning to obtain microscopic pore throat structure and element distribution before and after soaking the rock in CO2 solution. The core-scale experiment employed XRD to evaluate mineral content variation caused by CO2 solution. Core flooding experiments were conducted to evaluate porosity and permeability variation caused by the dissolution of CO2 solution into the core samples. The third type of experiment was employed to investigate the effect of time sequence on the dissolution, in which the time ranged from 1 day to 14 days continuously. The experimental results indicate that, under Jimsar reservoir conditions, CO2 solution exhibits a relatively robust dissolution capability, causing significant alterations to the properties of the core samples. Specifically, the CO2 solution effectively dissolves carbonate upon contact. Calcite is the primary target for dissolution, followed by dolomite. In the presence of sufficient CO2, complete dissolution of all carbonates is achievable. On a microscopic scale, dissolution primarily occurs in the calcium-rich areas, leaving other regions unaffected. The typical pore size resulting from CO2 solution-induced dissolution ranges from several to dozens of micrometers. This dissolution process significantly enhances both porosity and permeability. For Jimsar shale core samples, porosity experienced an increase of over 20%, and permeability nearly doubled. Under Jimsar reservoir conditions at 90 °C, CO2 solution can consume all carbonates present in core samples within 8 days. The increase in porosity and permeability is rapid during the initial days and stabilizes around the 6th day. These research findings establish a theoretical foundation for CO2 chemical sequestration.
Stability of the Roman Catholic Church Financing System Based on Germany
Authors: Mizak Anna , Sokołek Mariusz
Published: March 2024

To effectively carry out its tasks, the church needs a stable financial system. The aim of this article is to present issues related to ensuring the stability of the Catholic Church financing system in times of significant demographic and socio-cultural changes. This study identifies and characterizes the main sources of income and directions of expenses of the available financial resources. The challenges faced by church authorities in this regard are also described. State authorities finance places of prayer for social, cultural, and psychological reasons. Churches have been places of support in difficult times for centuries as well as places of survival and mental support for society.
The Effect of Corporate Governance on the Degree of Agency Cost in the Korean Market
Authors: Lee Younghwan , Tulcanaza-Prieto Ana Belén
Published: March 2024

This study examines the relationship between corporate governance (CG) and agency costs using Korean market data, particularly for chaebol firms. The final sample includes 660 firm-year observations between 2016 and 2020 for Korean non-financial firms listed on the Korean Composite Stock Price Index (KOSPI). This study employs an ordinary least-squares panel data regression model using two proxies for agency costs, namely, asset utilization ratio and operating expense ratio, and six CG individual metrics as independent variables (CG score, protection of shareholder rights, board structure, disclosure, audit organization, and managerial discretion and error management). We find that firms with high CG experience lower agency costs than those with low CG. Moreover, our evidence suggests that firms can decrease agency costs by improving the quality of CG. The results of our regression model also support the idea that CG is effective in reducing agency costs for chaebol firms but not for non-chaebol firms. Finally, our findings suggest that the implementation of effective CG mechanisms in firms might improve managerial behavior through better decision-making to maximize the value of firms.
Derivation of 3D Coseismic Displacement Field from Integrated Azimuth and LOS Displacements for the 2018 Hualien Earthquake
Authors: Lin Li-Chieh J. , Chuang Ray Y. , Lu Chih-Heng , Ching Kuo-En , Chen Chien-Liang
Published: March 2024

A 3D surface deformation field for an earthquake can aid in understanding fault behaviors and earthquake mechanisms. However, SAR-based 3D surface deformation estimates are often limited by insufficient observations and hampered by various error sources. In this study, we demonstrate the derivation of a 3D coseismic displacement field from different InSAR processing algorithms. The azimuth displacements from Multiple Aperture Interferometry (MAI) and Pixel Offset Tracking (POT) were integrated to ensure reliable displacements at low coherent areas. The 3D displacement field was inverted pixel-by-pixel by Line-of-Sight (LOS) displacement and integrated azimuth displacement. The results showed that MAI and POT could compensate for the weaknesses of each algorithm. Also, pixels with less than three sets of observations showed higher noise levels. Such noisy pixels were removed by a denoising criterion proposed herein. For the vertical direction, the proportion of pixels inverted with two sets of azimuth and one set of LOS displacements was 26.1%. After denoising, the proportion dropped to 2.4% due to the insufficiency of LOS displacements. This shows that the viewing angle influences the overall performance of 3D surface displacement inversion. Implementing various displacement vectors should reduce such limitations.
Research on Remote-Sensing Identification Method of Typical Disaster-Bearing Body Based on Deep Learning and Spatial Constraint Strategy
Authors: Wang Lei , Xu Yingjun , Chen Qiang , Wu Jidong , Luo Jianhui , Li Xiaoxuan , Peng Ruyi , Li Jiaxin
Published: March 2024

The census and management of hazard-bearing entities, along with the integrity of data quality, form crucial foundations for disaster risk assessment and zoning. By addressing the challenge of feature confusion, prevalent in single remotely sensed image recognition methods, this paper introduces a novel method, Spatially Constrained Deep Learning (SCDL), that combines deep learning with spatial constraint strategies for the extraction of disaster-bearing bodies, focusing on dams as a typical example. The methodology involves the creation of a dam dataset using a database of dams, followed by the training of YOLOv5, Varifocal Net, Faster R-CNN, and Cascade R-CNN models. These models are trained separately, and highly confidential dam location information is extracted through parameter thresholding. Furthermore, three spatial constraint strategies are employed to mitigate the impact of other factors, particularly confusing features, in the background region. To assess the method’s applicability and efficiency, Qinghai Province serves as the experimental area, with dam images from the Google Earth Pro database used as validation samples. The experimental results demonstrate that the recognition accuracy of SCDL reaches 94.73%, effectively addressing interference from background factors. Notably, the proposed method identifies six dams not recorded in the GOODD database, while also detecting six dams in the database that were previously unrecorded. Additionally, four dams misdirected in the database are corrected, contributing to the enhancement and supplementation of the global dam geo-reference database and providing robust support for disaster risk assessment. In conclusion, leveraging open geographic data products, the comprehensive framework presented in this paper, encompassing deep learning target detection technology and spatial constraint strategies, enables more efficient and accurate intelligent retrieval of disaster-bearing bodies, specifically dams. The findings offer valuable insights and inspiration for future advancements in related fields.
Spatiotemporal Variations and Sustainability Characteristics of Groundwater Storage in North China from 2002 to 2022 Revealed by GRACE/GRACE Follow-On and Multiple Hydrologic Data
Authors: Qu Wei , Zhang Pufang , Chen Peinan , Li Jiuyuan , Gao Yuan
Published: March 2024

North China (NC) is experiencing significant groundwater depletion. We used GRACE and GRACE-FO RL06 Level-2 data with Mascon data from April 2002 to July 2022. We fused these two types of data through the generalized three-cornered hat method and further combined them with hydrological models, precipitation, in situ groundwater-level, and groundwater extraction (GWE) data to determine and verify temporal and spatial variations in groundwater storage (GWS) in NC. We quantitatively assessed groundwater sustainability by constructing a groundwater index in NC. We further explored the dynamic cyclic process of groundwater change and quantified the impact of the South-to-North Water Transfer Project (SNWTP) on GWS change in NC. The overall GWS shows a decreasing trend. The GRACE/GRACE-FO-derived GWS change results are consistent with those shown by the in situ groundwater-level data from the monitoring well. Groundwater in NC is in various states of unsustainability throughout the period 2002 to 2022. The SNWTP affected the water use structure to some extent in NC. This study elucidates the latest spatial–temporal variations in GWS, especially in the groundwater sustainability assessment and quantitative description of the effects of the SNWTP on changes in GWS in NC. The results may provide a reference for groundwater resource management.