bluuebunny/crossref_metadata_2025 huggingface dataset:
Association of Pre-End-Stage Renal Disease Hemoglobin with Early Dialysis Outcomes
Authors: Kleine Carola-Ellen , Soohoo Melissa , Ranasinghe Omesh N. , Park Christina , Marroquin Maria V. , Obi Yoshitsugu , Rhee Connie M. , Moradi Hamid , Kovesdy Csaba P. , Kalantar-Zadeh Kamyar , Streja Elani
Published: May 2018

Background: Incident hemodialysis patients have a high mortality risk within the first months after dialysis initiation. Pre-end-stage renal disease (ESRD) factors like anemia management may impact early post-ESRD outcomes. Therefore, we evaluated the impact of pre-ESRD hemoglobin (Hgb) and pre-ESRD Hgb slope on post-ESRD mortality and hospitalization outcomes. Methods: The study included 31,472 veterans transitioning to ESRD. Using Cox and negative binomial regression models, we evaluated the association of pre-ESRD Hgb and Hgb slope with 12-month post-ESRD all-cause and cardiovascular mortality and hospitalization rates using 4 levels of hierarchical multivariable adjustment, including erythropoietin use and kidney decline in slope models. Results: The cohort was 2% female, 30% African-American, and on average 68 ± 11 years old. Compared to Hgb 10–< 11 g/dL, both low (< 10 g/dL) and high (≥12 g/dL) levels were associated with higher all-cause mortality after full adjustment (HR 1.25 [95% CI 1.15–1.35] and 1.09 [95% CI 1.02–1.18], respectively). Similarly, Hgb exhibited a U-shaped association with CV mortality, while only lower Hgb was associated with a higher hospitalization rate. Neither an annual pre-ESRD decline in Hgb nor increase was associated with higher post-ESRD mortality risk after adjustment for kidney decline. However, we observed a modest J-shaped association between pre-ESRD Hgb slope and post-ESRD hospitalization rate. Conclusions: Lower and higher pre-ESRD Hgb levels are associated with a higher risk of early post-ESRD mortality, while there was no association between the pre-ESRD slope and mortality. An increase in pre-ESRD Hgb slope was associated with higher risk of post-ESRD hospitalization. Additional studies aimed at anemia management prior to ESRD transition are warranted.
Parathyroid Hormone, Fibroblast Growth Factor 23, and Parameters of Phosphate Reabsorption
Authors: Phelps Kenneth R. , Mason Darius L.
Published: May 2018

Background: The serum phosphorus concentration ([P]s) is the sum of EP/Ccr and TRP/Ccr, where Ccr is creatinine clearance and EP and TRP are rates of excretion and reabsorption of phosphate. In chronic kidney disease (CKD), parathyroid hormone (PTH) and fibroblast growth factor 23 (FGF23) mediate reduction of TRP/Ccr, and [PTH] and [FGF23] are linear functions of EP/Ccr. If controls and patients with CKD are considered together, TRP/Ccr is a hyperbolic function of EP/Ccr. Given these observations, we hypothesized that hyperbolas would describe relationships of phosphate reabsorption to [PTH] and [FGF23]. Methods: We studied 30 patients and 28 controls with mean eGFR of 29.5 and 86.0 mL/min/1.73 m2, respectively. All analyses combined both subsets. We measured fasting [PTH] 1–84 and intact [FGF23], and determined contemporaneous EP/Ccr, TRP/Ccr, fractional excretion of phosphorus (FEP), and phosphate tubular maximum per volume of filtrate (TmP/GFR). We examined linear regressions of TRP/Ccr and TmP/GFR on 100/[PTH] and 100/[FGF23]; from linear equations we derived hyperbolic equations relating reabsorptive parameters to hormone concentrations. Results: TRP/Ccr and TmP/GFR were linear functions of 100/[PTH] and 100/[FGF23] and hyperbolic functions of [PTH] and [FGF23]. TRP/Ccr and TmP/GFR fell minimally over the ranges of EP/Ccr, [PTH], and [FGF23] seen in CKD. FEP rose with EP/Ccr despite stable phosphate reabsorption. Conclusions: Hyperbolas describe relationships of TRP/Ccr and TmP/GFR to [PTH] and [FGF23] if subjects with normal and reduced GFR are analyzed together. Although FEP rises with [PTH] and [FGF23] as GFR falls, the simultaneous increments do not signify hormonally mediated reductions in phosphate reabsorption.
Spatial Verification of Ensemble Precipitation: An Ensemble Version of SAL
Authors: Radanovics Sabine , Vidal Jean-Philippe , Sauquet Eric
Published: May 2018

Spatial verification methods able to handle high-resolution ensemble forecasts and analysis ensembles are increasingly required because of the increasing development of such ensembles. An ensemble extension of the structure–amplitude–location (SAL) spatial verification method is proposed here. The ensemble SAL (eSAL) allows for verifying ensemble forecasts against a deterministic or ensemble analysis. The eSAL components are equal to those of SAL in the deterministic case, thus allowing the comparison of deterministic and ensemble forecasts. The Mesoscale Verification Intercomparison over Complex Terrain (MesoVICT) project provides a dataset containing deterministic and ensemble precipitation forecasts as well as a deterministic and ensemble analysis for case studies in summer 2007 over the greater Alpine region. These datasets allow for testing of the sensitivity of SAL and eSAL to analysis uncertainty and their suitability for the verification of ensemble forecasts. Their sensitivity with respect to the main parameter of this feature-based method—the threshold for defining precipitation features—is furthermore tested for both the deterministic and ensemble forecasts. Our results stress the importance of using meaningful thresholds in order to limit any unstable behavior of the threshold-dependent SAL components. The eSAL components are typically close to the median of the distribution of deterministic SAL components calculated for all combinations of ensemble members of the forecast and the analysis, with considerably less computational time. The eSAL ensemble extension of SAL can be considered as a relevant summary measure that leads to more easily interpretable SAL diagrams.
Perceived Risk of Emerging Recreational Drugs: Impact of Anecdotal and Statistical Evidence
Authors: Gutierrez Kevin Michael , Cohn Lawrence D.
Published: May 2018

This study investigated the relative impact of personal stories and base rate evidence on the perceived risk of using two emerging recreational drugs: kratom and Spice. A 3 × 2 × 2 mixed-methods design was employed. Four hundred fifty-three young adults were randomly assigned to read internet postings that presented either 1) base rate information depicting the frequency of adverse reactions to Spice and kratom; 2) base rate information plus four personal web-postings describing beneficial reactions to Spice and kratom; or 3) base rate information plus four personal web-postings describing adverse reactions to Spice and kratom. Respondents subsequently evaluated the risk of using both drugs. Anecdotal evidence (personal stories) outweighed the impact of base rate evidence only when the personal stories described adverse drug reactions. Effective risk communication will benefit from differential use of both base rate evidence and personal stories.
Modeling the relationship between motivational beliefs, cognitive learning strategies, and academic performance of teacher education students
Authors: Muwonge Charles Magoba , Schiefele Ulrich , Ssenyonga Joseph , Kibedi Henry
Published: May 2018

Although self-regulated learning has received much attention over the past decades, research on how teacher education students regulate their own learning has been scarce, particularly in third world countries. In the present study, we examined the structural relationships between motivational beliefs, cognitive learning strategies, and academic performance among teacher education students in Uganda. The sample comprised of 1081 students selected from seven universities. Data were collected using several subscales from the modified Motivated Strategies for Learning Questionnaire and were analyzed by structural equation modeling. Cognitive learning strategies fully mediated the relationship between motivational beliefs and academic performance. Motivational beliefs contributed to students’ academic performance mainly through influencing their critical thinking and organizational skills. Therefore, interventions to improve teacher education students’ academic performance should focus not only on boosting their motivation but also on enhancing their use of cognitive learning strategies.
Assessing Correspondence Between Experimental and Nonexperimental Estimates in Within-Study Comparisons
Authors: Steiner Peter M. , Wong Vivian C.
Published: May 2018

In within-study comparison (WSC) designs, treatment effects from a nonexperimental design, such as an observational study or a regression-discontinuity design, are compared to results obtained from a well-designed randomized control trial with the same target population. The goal of the WSC is to assess whether nonexperimental and experimental designs yield the same results in field settings. A common analytic challenge with WSCs, however, is the choice of appropriate criteria for determining whether nonexperimental and experimental results replicate. This article examines different distance-based correspondence measures for assessing correspondence in experimental and nonexperimental estimates. Distance-based measures investigate whether the difference in estimates is small enough to claim equivalence of methods. We use a simulation study to examine the statistical properties of common correspondence measures and recommend a new and straightforward approach that combines traditional significance testing and equivalence testing in the same framework. The article concludes with practical advice on assessing and interpreting results in WSC contexts.
Oxygen dependency of mitochondrial metabolism indicates outcome of newborn brain injury
Authors: Bale Gemma , Mitra Subhabrata , de Roever Isabel , Sokolska Magdalena , Price David , Bainbridge Alan , Gunny Roxana , Uria-Avellanal Cristina , Kendall Giles S , Meek Judith , Robertson Nicola J , Tachtsidis Ilias
Published: May 2018

There is a need for a method of real-time assessment of brain metabolism during neonatal hypoxic-ischaemic encephalopathy (HIE). We have used broadband near-infrared spectroscopy (NIRS) to monitor cerebral oxygenation and metabolic changes in 50 neonates with HIE undergoing therapeutic hypothermia treatment. In 24 neonates, 54 episodes of spontaneous decreases in peripheral oxygen saturation (desaturations) were recorded between 6 and 81 h after birth. We observed differences in the cerebral metabolic responses to these episodes that were related to the predicted outcome of the injury, as determined by subsequent magnetic resonance spectroscopy derived lactate/N-acetyl-aspartate. We demonstrated that a strong relationship between cerebral metabolism (broadband NIRS-measured cytochrome-c-oxidase (CCO)) and cerebral oxygenation was associated with unfavourable outcome; this is likely to be due to a lower cerebral metabolic rate and mitochondrial dysfunction in severe encephalopathy. Specifically, a decrease in the brain tissue oxidation state of CCO greater than 0.06 µM per 1 µM brain haemoglobin oxygenation drop was able to predict the outcome with 64% sensitivity and 79% specificity (receiver operating characteristic area under the curve = 0.73). With further work on the implementation of this methodology, broadband NIRS has the potential to provide an early, cotside, non-invasive, clinically relevant metabolic marker of perinatal hypoxic-ischaemic injury.
Image-guided vacuum-assisted breast biopsy in the diagnosis of breast microcalcifications
Authors: Liu Jun , Huang Linping
Published: May 2018

Objective

The present study was performed to assess the accuracy and clinical value of image-guided vacuum-assisted breast biopsy in the diagnosis of mammography-detected breast microcalcifications.

Methods

This prospective study involved 100 patients with suspicious mammography-detected microcalcifications who underwent image-guided vacuum-assisted breast biopsies from January 2013 to October 2016. Stereotactic vacuum-assisted breast biopsy (SVAB) was performed in 64 patients, and ultrasound (US)-guided vacuum-assisted breast biopsy (US-VAB) was performed in 36 patients in whom application of SVAB was difficult. The microcalcifications were detectable by mammography or US. The mean follow-up duration was 32 months (range, 9–57 months). The biopsy results were correlated with the pathological examination results.

Results

The positive predictive value of microcalcifications detected by mammography and US in the diagnosis of breast cancer was 37.0% (37/100) and 52.8% (19/36), respectively. The negative predictive value of microcalcifications detected by US in the diagnosis of breast cancer was 71.9% (46/64). No recurrence was observed in the 37 patients with breast cancer. No evidence of malignancy was found among the 63 patients with benign lesions.

Conclusion

Image-guided vacuum-assisted breast biopsy is accurate and minimally invasive. It can be used as a safe approach for diagnosis in patients with breast microcalcifications.
Quantitative methods I: The world we have lost – or where we started from
Authors: Johnston Ron , Harris Richard , Jones Kelvyn , Manley David , Wang Wenfei Winnie , Wolf Levi
Published: May 2018

Although pioneering studies using statistical methods in geographical data analysis were published in the 1930s, it was only in the 1960s that their increasing use in human geography led to a claim that a ‘quantitative revolution’ had taken place. The widespread use of quantitative methods from then on was associated with changes in both disciplinary philosophy and substantive focus. The first decades of the ‘revolution’ saw quantitative analyses focused on the search for spatial order of a geometric form within an, often implicit, logical positivist framework. In the first of three reviews of the use of quantitative methods in human geography, this progress report uncovers their origin with regard to the underlying philosophy, the focus on spatial order, and the nature of the methods deployed. Subsequent reports will outline the changes in all three that occurred in later decades and will chart the contemporary situation.
Animal geographies III: Species relations of power
Authors: Hovorka Alice J.
Published: May 2018

In this final report on animal geographies, I address species relations of power. These relations reflect the relative power held by various animal groups, as expressed in their circumstances and experiences and as mediated through human-animal dynamics. Investigating the breadth and complexity of these power dynamics is important given that we live in a multispecies world and we continue to seek avenues for de-centring ‘the human’ in theory and practice. Animal geographies offer scholarly tools through which to explore, unpack, and interrogate multispecies hierarchical networks. The result is a holistic, in-depth view of relations of power that illuminates how animal social groups are bound up with humans, as well as with other animals, in ways that produce and reproduce species-based differences and inequalities.
Estimation of the characteristics with hydrothermal carbonisation temperature on poultry slaughterhouse wastes
Authors: Kim Ho , Han Seong Kuk , Song Eunhye , Park Seyong
Published: May 2018

This study is an assessment of the hydrothermal carbonisation of poultry slaughterhouse wastes sludge for the solid recovered fuel. The effects of hydrothermal carbonisation were evaluated by varying the reaction temperatures in the range of 170 °C–220 °C. After hydrothermal carbonisation was completed, the capillary suction time, time to filter, and particle size decreased by ranges of 170.4 to 25.9 s, 40 to 7.0 s, and 220 to 98 um, respectively, with increasing hydrothermal carbonisation temperature. This effect improved the dewaterability to release additional free water from the sludge. Moreover, hydrothermal carbonisation increased the heating value though the reduction of the hydrogen and oxygen content of solid fuel in addition to investigating drying performance. As shown in the Van Krevelen diagram, the H/C and O/C ratios decreased, in correlation with primary reactions of coalification. These results suggest that the hydrothermal carbonisation process is an advantageous technology in improving the properties of poultry slaughterhouse wastes as an alternative solid recovered fuel by converting the physical and chemical structure of the poultry slaughterhouse wastes in addition to also providing other benefits to treat organic and biomass waste.
What Role Does Planning Have in the Creation of Ecosystem Service Markets? Evidence from Two Cases in Oregon
Authors: van Maasakkers Mattijs
Published: May 2018

Ecosystem service markets (ESMs) facilitate the buying and selling of credits that represent specific environmental improvements, like a reduction in atmospheric carbon dioxide or a waterborne pollutant, such as phosphorous or nitrogen. The popularity of this institution has the potential to change land-use planning, especially at the regional level. This comparative analysis of two prominent ESMs in Oregon finds that these institutions can severely restrict opportunities for public participation in land-use decision making, reduce the transparency of measurement technologies used to target restoration activities, and prioritize privately owned land outside of urban areas for restoration investments, thereby limiting public access to green spaces.
Current Research Status of Palliative Care in Mainland China
Authors: Wang Tao , Molassiotis Alex , Chung Betty Pui Man , Tan Jing-Yu
Published: May 2018

Objectives:

This study aimed to obtain an overview of the current research status of palliative care in Mainland China and identify research directions for future studies by characterizing palliative care studies conducted among patients with any life-limiting illness in Mainland China and published in a peer-reviewed journal before November 2016.

Methods:

A review guide with 7 categories was initially developed based on existing international palliative care definitions and guidelines through content analysis. Ten databases were used to identify relevant studies from the inception of online cataloging to November 2016. Studies conducted in Mainland China and their research topic that fell within one of the categories of the review guide were included for further analysis. Descriptive analysis was adopted to summarize the relevant findings.

Results:

54 studies found to be relevant were included for the analysis. Three studies on “palliative care education and training” (category 1) asserted that education and training programs were scant in Mainland China and that only 1 program had been devised within the health-care context of Shanghai. Five studies on “palliative care screening and timely identification” (category 2) highlighted the absence of early screening criteria or checklists and referral procedures for palliative care. Thirty-one studies on “palliative care needs assessment (n = 12/31) and implementation (n = 19/31)” (category 3) were identified, and various methodological flaws were observed in most of these included studies. Twelve studies on “advanced decision-making” (category 4) were identified, all of which focused on investigating the attitudes of patients with cancer, their families, and/or health-care professionals toward advanced decision-making only. The percentage of patients, family members, and health-care professionals who held positive attitudes toward advanced decision-making were varied and suboptimal, particularly for family members (51.4%-58.0%). Five studies on “caring for patients at the end of life” (category 5) were identified, and the experience of health-care professionals in caring for those patients was explored. No studies relating to “death and bereavement care” (Category 6) and “psychological support for palliative care providers” (Category 7) were identified.

Conclusion:

The current research status of palliative care in Mainland China remains at an early stage with minimal palliative care services used. Although several knowledge gaps were identified, the first step, which should be addressed, is assessing the palliative care needs. An appropriate and ongoing needs assessment could provide important information for constructing comprehensive education and training programs of palliative care, identifying prognostic factors of timely palliative care referral, and developing evidence-based and tailored palliative care services.
Children and sexting: The case for intergenerational co-learning
Authors: Lee Nick , Hewett Angela , Rübner Jørgensen Clara , Turner Jerome , Wade Alex , Weckesser Annalise
Published: May 2018

Children’s sexting is presented as an emergent outcome of technology-based innovation in children’s peer-to-peer relations. We argue that it calls for creative responses that draw on adults’ and children’s understandings and views and on exchanges of these. We describe, and make the case for, intergenerational co-learning as a practice that could foster such creativity, as a pathway for children’s participation in the debate, and as a means by which media regulators, children’s service providers, and social media companies can consider and address their capabilities and responsibilities.
‘Brain Disorders’, by Henry Calderwood (1879)
Authors: Berrios GE
Published: May 2018

Henry Calderwood, a nineteenth-century Scottish philosopher interested in madness, published in 1879 an important work on the interaction between philosophy of mind, the nascent neurosciences and mental disease. Holding a spiritual view of the mind, he considered the phrase ‘mental disease’ (as Feuchtersleben had in 1845) to be but a misleading metaphor. His analysis of the research work of Ferrier, Clouston, Crichton-Browne, Maudsley, Tuke, Sankey, etc., is detailed, and his views are correct on the very limited explanatory power that their findings had for the understanding of madness. Calderwood’s conceptual contribution deserves to be added to the growing list of nineteenth-century writers who started the construction of a veritable ‘philosophy of alienism’ (now called ‘philosophy of psychiatry’).
The role of hepatic antioxidant capacity and hepatobiliary transporter in liver injury induced by isopsoralen in zebrafish larvae
Authors: Zhang Y , Zhang Y , Li J , Chen Y , Han L , He Q , Chu J , Liu K
Published: May 2018

Isopsoralen is the main component of the Chinese medicine psoralen, which has antitumour activity and can be used for the treatment of osteoporosis. However, the mechanism behind its hepatotoxicity has not yet been elucidated. In this study, the hepatotoxicity of isopsoralen was investigated using zebrafish. Isopsoralen treatment groups of 25, 50 and 100 μM were established. The mortality, liver morphology changes, levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST), liver histopathology and mRNA levels of liver injury–related genes in zebrafish larvae were measured. The results showed that isopsoralen resulted in the development of malformed zebrafish, dose-dependent increases in ALT and AST, decreased liver fluorescence and weakened fluorescence intensity. Histopathological examination showed that high-dose isopsoralen caused a large number of vacuolated structures in the larvae liver. The polymerase chain reaction results showed a significant decrease in the mRNA levels of genes related to antioxidant capacity ( lfabp, gstp2 and sod1) and drug transport ( mdr1, mrp1 and mrp2), indicating that isopsoralen significantly inhibited liver antioxidant capacity and drug efflux capacity in zebrafish larvae. Isopsoralen is hepatotoxic to zebrafish larvae via inhibition of drug transporter expression resulting in the accumulation of isopsoralen in the body and decreased antioxidant capacity, leading to liver injury.
School Nurses’ Management and Collaborative Practices for Student-Athletes Following Sport-Related Concussion
Authors: Weber Michelle L. , Welch Bacon Cailee E. , McLeod Tamara Valovich
Published: May 2018

The purpose of this study was to examine school nurses’ management and collaboration with health-care providers (HCPs) for student-athletes following a concussion. Secondary school nurses accessed an online survey titled the Beliefs, Attitudes, and Knowledge of Pediatric Athletes with Concussions (access rate = 15.6%; n = 1,246/8,000). Approximately 40% of schools where nurses were employed administered baseline and postinjury concussion assessments. No significant differences were found between employment model (single vs. multiple sites) in regard to conducting baseline ( p = .908) administration at their site; however, those employed at a single school more frequently offered postinjury assessments at their site than those at multiple sites ( p = .019). School nurses most frequently reported relationships with an athletic trainer (38.8%, n = 483/1,246) compared to other HCPs. A concussion management team, including school nurses, and other recommended members should develop comprehensive concussion management plans. Plans should comprise of multiple concussion assessments to aid in the return-to-learn/play processes.
Improved Glycemic Control With Minimal Change in Medication Regimen Complexity in a Pharmacist-Endocrinologist Diabetes Intense Medical Management (DIMM) “Tune Up” Clinic
Authors: Morello Candis M. , Rotunno Taylor , Khoan John , Hirsch Jan D.
Published: May 2018

Background: Gaining glycemic control in patients with type 2 diabetes (T2D) usually requires more complicated medication regimens. Increased medication regimen complexity (MRC) negatively impacts adherence and clinical outcomes. Objective: Compare MRC change in patients with uncontrolled T2D referred to a collaborative pharmacist-endocrinologist Diabetes Intense Medical Management (DIMM) clinic “tune up” model versus similar patients receiving usual primary care provider (PCP) care over 6 months. Methods: Retrospective, observational, comparative cohort study compared MRC of complex DIMM clinic patients to a similar group (adults with T2D, glycosylated hemoglobin [A1C] ≥8%), continuing to receive usual care from their PCPs. The MRC Index (MRCI) was used to quantify MRC. Results: Both DIMM (n=99) and PCP (n=56) groups were similar, with high baseline mean MRC scores as measured by number of medications and MRCI (12.0 [SD=5.7] vs 13.7 [SD = 5.6], and 32.7 [SD=17.0] vs 38 [SD=16.5]), respectively. Mean MRC change over 6 months was not significantly different between groups, although mean A1C reduction was significantly greater in the DIMM versus PCP group (−2.4% [SD=2.1] vs −0.8% [SD=1.7], P<0.001, respectively). Conclusions and Relevance: Outcomes represent the first report demonstrating how treating patients with an innovative DIMM model can help complex T2D patients achieve glycemic control without increasing the MRC to more than a comparator group. With the growing prevalence of T2D and associated elevated treatment costs, identifying effective means for achieving glycemic control without increasing complexity is needed. Application of this model may be considered by other health systems to aid in achieving outcome measures.
Incidence of arterial catheter complications: a retrospective study of 35 cats (2010–2014)
Authors: Mooshian Shaina , Deitschel Sarah J , Haggerty Jamie M , Guenther Christine L
Published: May 2018

Objectives

The aim of this study was to investigate the incidence of complications associated with arterial catheterization in cats in a veterinary hospital, and to document which factors may increase the incidence of complications.

Methods

Medical records at a referral veterinary hospital were retrospectively reviewed to identify cats that had an arterial catheter placed between January 2010 and October 2014.

Results

Thirty-five cats having 38 arterial catheters were included in the study. There was a relatively high incidence of minor complications (23.7%), with the most common being catheter occlusion. The incidence of major arterial catheter complications was low (2.63%). Duration of catheter use was positively correlated to the incidence of complications. There was also a significant correlation between catheters used for intensive care unit monitoring and incidence of complications. All cats with catheter complications survived to discharge.

Conclusions and relevance

The low incidence of major arterial catheter complications in this population of cats illustrates that arterial catheterization is a safe monitoring and diagnostic tool. The duration of catheter placement is significantly associated with the incidence of catheter complications.
Emerging Topics and Innovative Methodologies in Cannabis Research
Authors: Albright Victoria A , Johnson Eric Otto
Published: May 2018

Aims And Scope:

Cannabis use is ascendant in our society, affecting the health of our citizens, our social norms and social structures, and our economies. This special issue brings together a diverse set of research manuscripts that push the borders of our understanding of burgeoning cannabis use and displays innovative methods developed to study these phenomena.
Stability and incorporation: Toward a new concept of party system institutionalization
Authors: Piñeiro Rodríguez Rafael , Rosenblatt Fernando
Published: May 2018

Party system institutionalization (PSI) is a critical dimension of modern democracies. However, conventional approaches to institutionalization do not include party systems’ ability to adapt and respond to challenges that emanate from society, one of the crucial traits in Huntington’s definition of institutionalization. We discuss conventional approaches to the analysis of PSI. Building upon the idea of social orders put forth by North, Wallis, and Weingast, we argue that the analysis of institutionalization at the level of party systems must consider the system’s ability to provide open access and to include all sectors: that is, the system’s ability to incorporate demands that emanate from society. We propose a new conceptualization and operationalization of PSI, and we present a new data set of PSI indicators for 18 Latin American countries. Finally, we analyze the data to assess the level of PSI and type of party system in each Latin American country.
A Possibility to Square the Circle? Youth Uncertainty and the Imagination of Late Adulthood
Authors: Cuzzocrea Valentina
Published: May 2018

Youth transitions literature has traditionally devoted great attention to identifying and analysing events that are considered crucial to young people regarding their (short term) orientation to the future and wider narratives of the self. Such categories as ‘turning points’, ‘critical moments’, and ‘crossroads’ have been used to identify and explain the events around which young people take important decisions in order to realise the so-called transition to adulthood, each suggesting a sense of rupture. This focus sits within a central interest of youth transition literature, namely to investigate what hinders or facilitates independence. When looking more broadly at how young people imagine their future, however, taking a longer perspective opens insights not only in terms of ruptures, which these categories tend to refer to, but also in terms of the continuities that might also be very important in these narratives. Despite the methodological difficulties in getting young people to speak about their long future, this article seeks to discuss how they see their late adulthood through reflecting on how their narratives play out across different temporal horizons in order to establish their current priorities. Empirically, it is substantiated by essays on the future written by 18-year-old students based in Sardinia, and discusses in particular an emphasis which they put on the long as a term of fulfilment of their values.
Effects of a parent-implemented Developmental Reciprocity Treatment Program for children with autism spectrum disorder
Authors: Gengoux Grace W , Schapp Salena , Burton Sarah , Ardel Christina M , Libove Robin A , Baldi Gina , Berquist Kari L , Phillips Jennifer M , Hardan Antonio Y
Published: May 2018

Developmental approaches to autism treatment aim to establish strong interpersonal relationships through joint play. These approaches have emerging empirical support; however, there is a need for further research documenting the procedures and demonstrating their effectiveness. This pilot study evaluated changes in parent behavior and child autism symptoms following a 12-week Developmental Reciprocity Treatment parent-training program. A total of 22 children with autism spectrum disorder between 2 and 6 years (mean age = 44.6 months, standard deviation = 12.7) and a primary caregiver participated in 12 weekly sessions of Developmental Reciprocity Treatment parent training, covering topics including introduction to developmental approaches, supporting attention and motivation, sensory regulation and sensory-social routines, imitation/building nonverbal communication, functional language development, and turn taking. Results indicated improvement in aspects of parent empowerment and social quality of life. Improvement in core autism symptoms was observed on the Social Responsiveness Scale total score (F(1,19): 5.550, p = 0.029), MacArthur–Bates Communicative Development Inventories number of words produced out of 680 (F(1,18): 18.104, p = 0.000), and two subscales of the Repetitive Behavior Scale, Revised (compulsive, p = 0.046 and restricted, p = 0.025). No differences in sensory sensitivity were observed on the Short Sensory Profile. Findings from this pilot study indicate that Developmental Reciprocity Treatment shows promise and suggest the need for future controlled trials of this developmentally based intervention.
Health-Related Quality of Life after Restorative Proctocolectomy: A Cross-Sectional Study
Authors: Helavirta I. , Hyöty M. , Oksanen P. , Huhtala H. , Haapamäki J. , Aitola P.
Published: May 2018

Background and Aims:

Patients undergoing restorative proctocolectomy have often suffered from active ulcerative colitis which should be remembered when assessing quality of life after operation. The aim of this study was to explore health-related quality of life after restorative proctocolectomy in those with poor or good pouch function and to compare that to patients with active or inactive ulcerative colitis and to the general population.

Material and Methods:

Altogether, 282 restorative proctocolectomy patients were investigated. The control group comprised 408 ulcerative colitis patients from the local register. Generic 15D and disease-specific inflammatory bowel disease questionnaire health-related quality of life instruments were used. Population-based data were available for 15D. Pouch function was evaluated with Öresland score and colitis activity with simple clinical colitis activity index.

Results:

15D results showed that patients with good pouch function had health-related quality of life similar to that of the general population. Health-related quality of life with inflammatory bowel disease questionnaire was equally good in patients with good pouch function (n = 131; 70%) and inactive colitis (n = 95; 63%), and equally impaired in patients with poor pouch function (n = 56; 30%) and active colitis (n = 18; 12%).

Conclusion:

The majority of patients had health-related quality of life comparable to that in general population. Most patients with active ulcerative colitis are likely to improve their health-related quality of life after successful surgery. These findings are important when informing colitis patients about life after surgery.
The incidence and impact of implantable cardioverter defibrillator shocks in the last phase of life: An integrated review
Authors: Stoevelaar Rik , Brinkman-Stoppelenburg Arianne , Bhagwandien Rohit E , van Bruchem-Visser Rozemarijn L , Theuns Dominic AMJ , van der Heide Agnes , Rietjens Judith AC
Published: May 2018

Background:

Although the implantable cardioverter defibrillator is successful in terminating life threatening arrhythmias, it might give unwanted shocks in the last phase of life if not deactivated in a timely manner.

Aims:

This integrated review aimed to provide an overview of studies reporting on implantable cardioverter defibrillator shock incidence and impact in the last phase of life.

Methods and results:

We systematically searched five electronic databases. Studies reporting on the incidence and/or impact of implantable cardioverter defibrillator shocks in the last month of life were included. Fifteen studies were included. Two American studies published in 1996 and 1998 reported on the incidence of shocks in patients who died non-suddenly: incidences were 24% and 33%, respectively, in the last 24 hours, and 7% and 14%, respectively, in the last hour of life. Six American studies and one Danish study published between 1991–1999 reported on patients dying suddenly: incidences were 41% and 68% in the last 24 hours and 22–66% in the last hour. Four American studies and two Swedish studies published between 2004–2015 did not distinguish the cause of death: incidences were 17–32% in the last month, 3–32% in the last 24 hours, and 8% and 31% in the last hour of life. Three American studies published between 2004–2011 reported that shocks in dying patients are painful and distressing for patients, and distressing for relatives and professional caregivers.

Conclusion:

If the implantable cardioverter defibrillator is not deactivated in a timely manner, a potentially significant proportion of implantable cardioverter defibrillator patients experience painful and distressing shocks in their last phase of life.
A Cohort Study to Examine the Use of Chinese Herbal Medicine in Combination With Conventional Therapies for Patients With Hepatocellular Carcinoma in China
Authors: Sun Lingling , Fahey Paul , Zhu Xiaoshu , Ng Weng , Chen Zhuo Ping , Qiu Yiwen , Lai Hezheng , Lin Jietao , Lin Lizhu
Published: May 2018

Background. Hepatocellular carcinoma (HCC) is one of the major malignancies associated with high mortality rates. Chinese herbal medicine (CHM) alone, or in combination with conventional therapies (CT), has been widely used for patients with HCC in China. This study aims to explore how integrative therapy (IT) through the combination of CHM and CT affects the survival of patients with intermediate-advanced HCC. Methods. A retrospective cohort study was performed at the First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China. Data of consecutive patients diagnosed with intermediate-advanced HCC and a specific traditional Chinese medicine diagnostic pattern between January 2006 and December 2013 were retrieved from the electronic medical record system at the hospital. Patients were divided into 3 groups based on the therapies used, that is, IT, CHM alone, and CT alone, and the survival times of these patients was compared. Results. A total of 328 patients were included in this study. Median follow-up period was 26.4 months (95% confidence interval [CI] = 22.7-38.9). Median overall survival was 11.0 months for IT, 8.6 months for CHM, and 9.4 months for CT groups ( P < .001). The adjusted hazard ratio (HR) of death for the IT group was 0.55 (95% CI = 0.38-0.79, P = .001) relative to the CT group and 0.68 (95% CI = 0.52-0.90, P = .007) relative to the CHM group, after adjusting for the factors that impact prognosis. Stratified analysis shows that IT can significantly lower the risk of death, especially for patients with good performance status (PS) and Child-Pugh class A. Conclusions. It was indicated that the integrative approach with combination of CHM and CT might improve survival for patients with intermediate-advanced HCC, especially for patients with good PS and Child-Pugh class A. However, a randomized controlled trial is warranted for a conclusive statement.
Men’s Preconception Health: A Primary Health-Care Viewpoint
Authors: O’Brien Anthony Paul , Hurley John , Linsley Paul , McNeil Karen Anne , Fletcher Richard , Aitken John Robert
Published: May 2018

The purpose of this article is to theoretically explore men’s preconception health as a mechanism to enhance fertility, as well as the health and well-being of the subject and his descendants. Premorbid risk factors and behaviors associated with stress, environmental toxins, excessive alcohol consumption, smoking, lack of exercise/obesity, and the use of illicit drugs are all known to affect fecundity. While there are many health clinics available to women, where advice in areas such as postnatal care of the newborn, family planning, and couples fertility is provided, there are few, if any, equivalent health clinics available to men.

Additionally, getting men to attend primary health-care services has also been continuously problematic, even in the context of there being a clearly discernible need for treatment. It is argued in this article that an impetus is required to encourage men to focus on and improve their preconception health and to utilize primary health-care services to take action. An assertive men’s preconception health outlook can positively influence the conjugal relationship, fathering, male self-esteem, and continued good health. Using the sometimes complex concept of preconception health as a motivating factor for healthy lifestyle adaptation has the potential to improve male fertility outcomes and general health and well-being, as well as the health of future generations.
Thermal–structural coupling analysis of brake friction pair based on the displacement gradient circulation method
Authors: Zhang Shengfang , Yin Jian , Liu Yu , Liu Nan , Sha Zhihua , Wang Yanan , Rolfe Bernard
Published: May 2018

In view of the braking process for the megawatt wind turbine brakes, considering the geometric and motion characteristics of brake pads and brake discs, a displacement gradient circulation method is put forward in this article, to resolve the deviation of coupling results caused by the difference of friction effect along the radial/circumferential direction of brake disc, and the thermal–structural coupling analysis of friction pair during the braking process is carried out. A three-dimensional model of transient heat transfer for brake friction pair is built based on the Abaqus software. The heat flow density is loaded by the displacement gradient circulation method, which is used to calculate the frictional heat flow during the braking process. The analysis results show that along the circumferential direction of the brake disc the temperature distribution in the friction zone is non-uniform and the temperature starting from the contact position of the brake disc and the brake pad decreases along the counterclockwise direction. The thermal stress caused by the temperature field during the braking process is the main factor causing the brake disc/pad failure. The effectiveness of the method and the model is verified by the designed inertia braking experiments. The analytical method proposed in this article provides a reference for simulating the friction braking process of large-size disc brakes.
Chronic pain and associated factors in Maputo, Mozambique: a pilot study
Authors: Walters Camila B , Schwalbach Teresa , Sevene Esperança , Walters Jenna , Jackson Tracy , Hiremath Girish , Moon Troy D , McQueen KA Kelly
Published: May 2018

Introduction:

Studies estimate that 20% of adults suffer from chronic pain. A meta-analysis in low- and middle-income countries (LMICs) found 34% had chronic pain. There are few studies on pain prevalence gathered in Africa. This study surveyed the capital city of Mozambique.

Methods:

This was a cross-sectional study employed in a community setting. The Vanderbilt Global Pain Survey comprised questions on the behaviour and attitudes of respondents regarding pain, including previously validated metrics: the Pain Catastrophizing Scale, the World Health Organization Disability Assessment Schedule, the Brief Pain Inventory, Widespread Pain Index and Symptom Severity Score, and the Michigan Body Map.

Results:

Ninety-seven surveys were completed out of 100. Pain every day lasting for more than 6 months in their lifetime was reported as 39.2% (CI: 29.4–49.6), and 52% of respondents had pain the day of the interview. However, the pain resulted in little difficulty with activities of daily living and maintaining relationships (61%–89%). Although none reported mental health disorders, 53.6% had experienced a traumatic event in their life, with 45.2% having related nightmares, anxiety, or fear. Most respondents (99%) would take oral medication if it helped their pain, with a large proportion willing to spend significant money for these (49% would pay >US$40) and willing to travel long distances to get help (55.2% would travel >40 kilometer).

Conclusion:

The prevalence of chronic pain in Maputo, Mozambique is similar to the average for LMICs. Trends in high-income countries suggest that multimodal pain management and multidisciplinary treatments may improve optimal pain control in LMICs.
Latina/o School Administrators and the Intersectionality of Professional Identity and Race
Authors: Murakami Elizabeth , Hernandez Frank , Valle Fernando , Almager Irma
Published: May 2018

This study examines the intersectionality between professional identities and race/ethnicity among Latina/o school leaders. Stemming from a larger study at the National Latina/o Leadership Project, we examine the contributions of Latina/o school administrators in the state of Texas in relation to their leadership in K-12 schools. Two hundred twenty-six respondents inform this study. Descriptive and content analyses of data revealed that the intersectionality of race and class as influencing the work of school administrators and described how, among major influences, their own schooling experiences had an impact in the development of their professional identities.
Comparison of Canadian and Dutch Urban Parents and Grandparents in Terms of Knowledge of Children’s Cognitive and Social–Emotional Development
Authors: Vreeburg Leontien E. , Diekstra René F. W. , Sklad Marcin J. , Lundy Courtney D. , Tough Suzanne C.
Published: May 2018

Knowledge of child development influences parental expectations of, and interactions with, children. Studies have shown that maternal knowledge supports cognitive and social–emotional development of young children and can have long-lasting benefits. Level of developmental knowledge of parents and grandparents has seldom been investigated on a population level. Our aim was to compare Canadian and Dutch samples of urban parents and grandparents in terms of normative knowledge of children’s cognitive and social–emotional development. Urban parents ( n = 379) and grandparents ( n = 174) from the province of Alberta, Canada ( N = 553) and parents ( n = 634) and grandparents ( n = 96) of the city of The Hague in the Netherlands ( N = 730) answered questions related to knowledge of cognitive and social–emotional development of young children, including topics such as “do children have stronger bonds with parents who stay at home instead of working outside the home?” and “do children learn more from hearing someone in the same room talk than hearing someone on TV?” Overall, the Canadian respondents were more likely to answer these questions correctly. In both samples, women were more likely than men to answer correctly. No significant relationship between age or role (parent or grandparent) and knowledge was identified, but there was a positive correlation between knowledge and level of education. Little is known about international differences in caregivers’ knowledge about normative child development. This study suggests that differences exist. Understanding differences between countries in parental knowledge may provide insight into cross-cultural variability in child behavioral and developmental outcomes.