bluuebunny/crossref_metadata_2025 huggingface dataset:
Supplementary Figure from A Phase I Study of Quisinostat (JNJ-26481585), an Oral Hydroxamate Histone Deacetylase Inhibitor with Evidence of Target Modulation and Antitumor Activity, in Patients with Advanced Solid Tumors
Authors: Venugopal Balaji , Baird Richard , Kristeleit Rebecca S. , Plummer Ruth , Cowan Richard , Stewart Adam , Fourneau Nele , Hellemans Peter , Elsayed Yusri , Mcclue Steve , Smit Johan W. , Forslund Ann , Phelps Charles , Camm John , Evans T.R. Jeffry , de Bono Johann S. , Banerji Udai
Published: April 2023

Supplementary Figure 1a,b - PDF file 45K, Plasma concentration-time profile of 12 mg quisinostat on (a) day 1 and (b) at steady state for MWF treatment schedule
Supplementary Table 3 from Glioma Grade Is Associated with the Accumulation and Activity of Cells Bearing M2 Monocyte Markers
Authors: Prosniak Michael , Harshyne Larry A. , Andrews David W. , Kenyon Lawrence C. , Bedelbaeva Kamila , Apanasovich Tatiyana V. , Heber-Katz Ellen , Curtis Mark T. , Cotzia Paolo , Hooper D. Craig
Published: April 2023

PDF - 73K, Correlation between expression levels of IL-10, TGF-beta1, TGF-beta2 and GBM-assorted genes in primary GBM tissues.
Supplementary Figure Legends from Glioma Grade Is Associated with the Accumulation and Activity of Cells Bearing M2 Monocyte Markers
Authors: Prosniak Michael , Harshyne Larry A. , Andrews David W. , Kenyon Lawrence C. , Bedelbaeva Kamila , Apanasovich Tatiyana V. , Heber-Katz Ellen , Curtis Mark T. , Cotzia Paolo , Hooper D. Craig
Published: April 2023

PDF - 56K
Supplementary Table 2 from Targeting PI3K/mTOR Overcomes Resistance to HER2-Targeted Therapy Independent of Feedback Activation of AKT
Authors: O'Brien Neil A. , McDonald Karen , Tong Luo , von Euw Erika , Kalous Ondrej , Conklin Dylan , Hurvitz Sara A. , di Tomaso Emmanuelle , Schnell Christian , Linnartz Ronald , Finn Richard S. , Hirawat Samit , Slamon Dennis J.
Published: April 2023

XLSX file - 213K, Table S2. Summary of in vivo activity of BKM120, BYL719, RAD001 and BEZ235 in breast cancer tumor models. T/C: Ratio of mean tumor volume of treated (T) to control (C) at final day of treatment. Final day was determined as the final day of treatment for the vehicle control arm for each study in Figure 5. Comparisons between groups were all made by Repeated Measures ANOVA (RMANOVA) followed by Dunnett test for multiple comparisons. BW: body weight; TR: treatment related; NTR: non-treatment related.
Supplementary Figure 2 from Targeting PI3K/mTOR Overcomes Resistance to HER2-Targeted Therapy Independent of Feedback Activation of AKT
Authors: O'Brien Neil A. , McDonald Karen , Tong Luo , von Euw Erika , Kalous Ondrej , Conklin Dylan , Hurvitz Sara A. , di Tomaso Emmanuelle , Schnell Christian , Linnartz Ronald , Finn Richard S. , Hirawat Samit , Slamon Dennis J.
Published: April 2023

PDF file - 40K, Figure S2: Biomarkers of in vivo response to inhibitors of PI3K/mTOR signaling. Reverse Phase Protein Analysis (RPPA) of KPL-1 tumor samples taken after 7 days treatment with the molecules indicated. Tumors taken 24 hours post final dose. A, pAKT Ser473. B, pS6 Ser235/236.
Supplementary Figure S2 from Expression Defect Size among Unclassified MLH1 Variants Determines Pathogenicity in Lynch Syndrome Diagnosis
Authors: Hinrichsen Inga , Brieger Angela , Trojan Jörg , Zeuzem Stefan , Nilbert Mef , Plotz Guido
Published: April 2023

PDF file - 67 KB, MLH1 mRNA and protein levels after transfection (assay validation). A. HEK293T cells were transiently co-transfected with increasing amount of MLH1-PMS2 expression vectors (1-10 �g). Cells were harvested after 48 h and total RNA was isolated. MLH1 transcripts were quantified by qPCR. Average % values (relative to the standard transfection conditions using 5 �g DNA) from several independent determinations are shown. Error bars indicate the standard error of the mean. A binomical trend line (r = 0.942) demonstrates that the standard transfection conditions (5 �g) are within the range of optimal transcript production. "Control" represents an untransfected sample. B. From the same samples used for transcript quantification in A, protein extracts were produced and analyzed by SDS-PAGE and immunoblotting for expression levels of MLH1. Detection of �-actin served as loading control. C. MLH1 mRNA and protein were quantified as described in A using HEK293 cells (endogenous MLH1) and HEK293T cells transfected with MLH1. Transfected HEK293T cells had on average 740 times (�5.7% SEM) more transcript as HEK293 cells, but expressed only 53 times (� 56% SEM) more protein, confirming that translation is the rate-limiting step of this expression system. D. MLH1 mRNA levels of HEK293T cells transfected with wild-type MLH1-PMS2 and the indicated MLH1 variants were quantified by qPCR. Results from several independent experiments were evaluated relative to the respective wild-type mRNA levels. Error bars indicate the standard error of the mean.
Supplementary Figures 1 - 2 from S100B Promotes Glioma Growth through Chemoattraction of Myeloid-Derived Macrophages
Authors: Wang Huaqing , Zhang Leying , Zhang Ian Y. , Chen Xuebo , Da Fonseca Anna , Wu Shihua , Ren Hui , Badie Sam , Sadeghi Sam , Ouyang Mao , Warden Charles D. , Badie Behnam
Published: April 2023

PDF file - 305K, Figure 1. Effect of S100B upregulation on HMGB1 expression. HMGB1 production was measured by Western (top) and ELISA (bottom). Experimental results are representative of two separate experiments (n=3, plus-minus SD). Figure 2. Effect of RAGE blockade on tumor inflammation. GL261-S100Bwt cells were implanted into frontal lobes of WT or Rage-/- mice. Tumor leukocytes were quantified one and two weeks later as described in Methods. MG: microglia (CD11bhigh CD45low), MP: macrophage (CD11high CD45high). Experimental results are representative of two separate experiments (n=4mice/group, plus-minus SD).
Supplementary Figure 2 from MicroRNA-200a Promotes Anoikis Resistance and Metastasis by Targeting YAP1 in Human Breast Cancer
Authors: Yu San-Jian , Hu Jing-Ying , Kuang Xia-Ying , Luo Jian-Min , Hou Yi-Feng , Di Gen-Hong , Wu Jiong , Shen Zhen-Zhou , Song Hou-Yan , Shao Zhi-Ming
Published: April 2023

PDF file - 250K, The expression of EMT marker in MDA-MB-231 and MCF-7 cells
Supplementary Methods and Figure Legend from Impairment of Glioma Stem Cell Survival and Growth by a Novel Inhibitor for Survivin–Ran Protein Complex
Authors: Guvenc Hacer , Pavlyukov Marat S. , Joshi Kaushal , Kurt Habibe , Banasavadi-Siddegowda Yeshavanth K. , Mao Ping , Hong Christopher , Yamada Ryosuke , Kwon Chang-Hyuk , Bhasin Deepak , Chettiar Somsundaram , Kitange Gaspar , Park In-Hee , Sarkaria Jann N. , Li Chenglong , Shakhparonov Mihail I. , Nakano Ichiro
Published: April 2023

PDF file - 114K
Supplementary Figure 6 from Combined Immunostimulatory Monoclonal Antibodies Extend Survival in an Aggressive Transgenic Hepatocellular Carcinoma Mouse Model
Authors: Morales-Kastresana Aizea , Sanmamed Miguel F. , Rodriguez Inmaculada , Palazon Asis , Martinez-Forero Ivan , Labiano Sara , Hervas-Stubbs Sandra , Sangro Bruno , Ochoa Carmen , Rouzaut Ana , Azpilikueta Arantza , Bolaños Elixabet , Jure-Kunkel Maria , Gütgemann Ines , Melero Ignacio
Published: April 2023

PDF file - 2976K, HCC cell lines derived from c-myc OVA tg+ mice express OVA and functional antigen presenting molecules.
Supplementary Table 4 from Tumor Genetic Analyses of Patients with Metastatic Renal Cell Carcinoma and Extended Benefit from mTOR Inhibitor Therapy
Authors: Voss Martin H. , Hakimi A. Ari , Pham Can G. , Brannon A. Rose , Chen Ying-Bei , Cunha Luis F. , Akin Oguz , Liu Han , Takeda Shugaku , Scott Sasinya N. , Socci Nicholas D. , Viale Agnes , Schultz Nikolaus , Sander Chris , Reuter Victor E. , Russo Paul , Cheng Emily H. , Motzer Robert J. , Berger Michael F. , Hsieh James J.
Published: April 2023

XLSX file - 910K, Supplementary Table S4. Impact assay exon coverage on all samples.
Supplementary Figures 1 - 11, Tables 1 - 2 from Tumor Genetic Analyses of Patients with Metastatic Renal Cell Carcinoma and Extended Benefit from mTOR Inhibitor Therapy
Authors: Voss Martin H. , Hakimi A. Ari , Pham Can G. , Brannon A. Rose , Chen Ying-Bei , Cunha Luis F. , Akin Oguz , Liu Han , Takeda Shugaku , Scott Sasinya N. , Socci Nicholas D. , Viale Agnes , Schultz Nikolaus , Sander Chris , Reuter Victor E. , Russo Paul , Cheng Emily H. , Motzer Robert J. , Berger Michael F. , Hsieh James J.
Published: April 2023

PDF file - 3248K, Supplementary Table S1. Histopathologic findings for multi-region analysis. Supplementary Table S2.IMPACT gene list and their respective chromosomal positions. Supplementary Table S5. WEC run statistics on patients #4 and #5. Supplementary Table S6.List of all non-variant mutations detected by IMPACT assays in individual patient samples. Supplementary Table S7. Non-variant mutations identified by WEC in patients #4 and #5. Supplementary Figure 1. Flow chart depicts the IMPACT assay mutation identification and filtering algorithm. Supplementary Figure 2. Flow chart depicts the WEC assay mutation identification and filtering algorithm. Supplementary Figure 3. Sanger validations of mutations in the targeted pathway indentified by IMPACT assay for R1 of patients #1,#2, and #3. Supplementary Figure 4. Sanger validations of mutations in the targeted pathway indentified by IMPACT assay for additional regions analyzed for patients #1, and #3. Supplementary Figure 5. The Q2223K mTOR mutation provokes hyperactivation of mTORC1 in serum free growth conditions. Supplementary Figure 6. Hyperactivation of mTORC1 induced by Q2223K is sensitive to rapalog-based mTOR inhibition. Supplementary Figure 7. Immunoblots detecting phosphorylated mTOR at serine residues 2448 (S2448) and 2481 (S2481). Supplementary Figure 8. Copy number plots for multiple tumor regions in patient #3 showing the loss of chromosome 9 only in tumor regions carrying the TSC1 nonsense mutation (R3, R4). Supplementary Figure 9. Copy number plots for patient with tuberous sclerosis complex and metastatic unclassified RCC with extended benefit from everolimus therapy (44+ months). Supplementary Figure 10. PI3K pathway alterations as reported across 418 cases of clear cell RCC in TCGA. Alterations are detected in 42% of cases. Supplementary Figure 11: Hematoxylin and eosin (H&E) stains and immunohistochemistry for 4EBP1 phosphorylation (Thr 37/46), an mTORC1 downstream effector, in primary kidney tumors and adjacent normal kidney tissue for patients 1-5.
Supplementary Figure 7 from An Unconventional KITENIN/ErbB4-Mediated Downstream Signal of EGF Upregulates c-Jun and the Invasiveness of Colorectal Cancer Cells
Authors: Bae Jeong A. , Yoon Somy , Park So-Yeon , Lee Jae Hyuk , Hwang Jun-Eul , Kim Hangun , Seo Young-Woo , Cha Yoon Jin , Hong Sung Pil , Kim Hoguen , Chung Ik Joo , Kim Kyung Keun
Published: April 2023

PDF file - 138K, Figure 7. Co-transfection of both KITENIN and ErbB4 induced greater elevation in AP-1 activity after EGF treatment.
Supplementary Figure 6 from An Unconventional KITENIN/ErbB4-Mediated Downstream Signal of EGF Upregulates c-Jun and the Invasiveness of Colorectal Cancer Cells
Authors: Bae Jeong A. , Yoon Somy , Park So-Yeon , Lee Jae Hyuk , Hwang Jun-Eul , Kim Hangun , Seo Young-Woo , Cha Yoon Jin , Hong Sung Pil , Kim Hoguen , Chung Ik Joo , Kim Kyung Keun
Published: April 2023

PDF file - 206K, Figure 6. Modulation of multiple RTKs in KITENIN-overexpressed Caco2 or KITENIN-knockdown HCT116 CRC cells.
Supplementary Table 2 from Deciphering the Mechanisms of Tumorigenesis in Human Pancreatic Ductal Epithelial Cells
Authors: Chang Zhe , Li Zhongkui , Wang Xiaoyang , Kang Ya'an , Yuan Yuhui , Niu Jiangong , Wang Huamin , Chatterjee Deyali , Fleming Jason B. , Li Min , Abbruzzese James L. , Chiao Paul J.
Published: April 2023

PDF file - 74K, Supplementary Table 2. The most significant changes in gene expression for cell line HPDE/Kras/ Her2/p16p14shRNA/Smad4shRNA versus cell line HPDE/K-ras/Her2/p16p14shRNA in cDNA microarray analysis.
Supplementary Figure 1 from CHFR Protein Expression Predicts Outcomes to Taxane-Based First Line Therapy in Metastatic NSCLC
Authors: Pillai Rathi N. , Brodie Seth A. , Sica Gabriel L. , Shaojin You , Li Ge , Nickleach Dana C. , Yuan Liu , Varma Vijay A. , Bonta Dacian , Herman James G. , Brock Malcom V. , Ribeiro Maria J.A. , Ramalingam Suresh S. , Owonikoko Taofeek K. , Khuri Fadlo R. , Brandes Johann C.
Published: April 2023

PDF file - 53K, ROC curve to determine the best cutoff value for CHFR intensity
Supplementary Methods from Deciphering the Mechanisms of Tumorigenesis in Human Pancreatic Ductal Epithelial Cells
Authors: Chang Zhe , Li Zhongkui , Wang Xiaoyang , Kang Ya'an , Yuan Yuhui , Niu Jiangong , Wang Huamin , Chatterjee Deyali , Fleming Jason B. , Li Min , Abbruzzese James L. , Chiao Paul J.
Published: April 2023

PDF file - 114K
Supplementary Figure 1 from Combination of Ponatinib with Hedgehog Antagonist Vismodegib for Therapy-Resistant BCR-ABL1–Positive Leukemia
Authors: Katagiri Seiichiro , Tauchi Tetsuzo , Okabe Seiichi , Minami Yosuke , Kimura Shinya , Maekawa Taira , Naoe Tomoki , Ohyashiki Kazuma
Published: April 2023

PDF file - 47 KB, SK-9 cells were treated with 1 mM of nilotinib or 200 nM of dasatinib or 40 nM of ponatinib for 48 hrs. The cytoplasmic cell lysates and nuclear extracts were immunoblotted with anti-Gli1 Abs or anti-ABL Ab.
Supplementary Methods from miR-187 Is an Independent Prognostic Factor in Breast Cancer and Confers Increased Invasive Potential In Vitro
Authors: Mulrane Laoighse , Madden Stephen F. , Brennan Donal J. , Gremel Gabriela , McGee Sharon F. , McNally Sara , Martin Finian , Crown John P. , Jirström Karin , Higgins Desmond G. , Gallagher William M. , O'Connor Darran P.
Published: April 2023

PDF file - 85K, qRT-PCR, standard in vitro functional assays and Western blotting description
Supplementary Table S2 from Integration of Metabolomics and Transcriptomics Revealed a Fatty Acid Network Exerting Growth Inhibitory Effects in Human Pancreatic Cancer
Authors: Zhang Geng , He Peijun , Tan Hanson , Budhu Anuradha , Gaedcke Jochen , Ghadimi B. Michael , Ried Thomas , Yfantis Harris G. , Lee Dong H. , Maitra Anirban , Hanna Nader , Alexander H. Richard , Hussain S. Perwez
Published: April 2023

Supplementary Table S2 - PDF file 64K, A list of 55 metabolites differentially expressed in two independent cohorts of PDAC cases
Supplementary Figure 2 from Combined Targeting of STAT3/NF-κB/COX-2/EP4 for Effective Management of Pancreatic Cancer
Authors: Gong Jingjing , Xie Jianping , Bedolla Roble , Rivas Paul , Chakravarthy Divya , Freeman James W. , Reddick Robert , Kopetz Scott , Peterson Amanda , Wang Huamin , Fischer Susan M. , Kumar Addanki P.
Published: April 2023

PDF file - 1144KB, Histograms of FITC-Annexin staining.
Supplementary Figure from Perioperative Influenza Vaccination Reduces Postoperative Metastatic Disease by Reversing Surgery-Induced Dysfunction in Natural Killer Cells
Authors: Tai Lee-Hwa , Zhang Jiqing , Scott Karen J. , de Souza Christiano Tanese , Alkayyal Almohanad A. , Ananth Anu Abhirami , Sahi Shalini , Adair Robert A. , Mahmoud Ahmad B. , Sad Subash , Bell John C. , Makrigiannis Andrew P. , Melcher Alan A. , Auer Rebecca C.
Published: April 2023

PDF file, 190K, Prophylactic vaccines enhance NK cell cytotoxicity.
Supplementary Figures 1 - 6 from RRM2 Regulates Bcl-2 in Head and Neck and Lung Cancers: A Potential Target for Cancer Therapy
Authors: Rahman Mohammad Aminur , Amin A.R.M. Ruhul , Wang Dongsheng , Koenig Lydia , Nannapaneni Sreenivas , Chen Zhengjia , Wang Zhibo , Sica Gabriel , Deng Xingming , Chen Zhuo (Georgia) , Shin Dong M.
Published: April 2023

PDF file - 427K, Figure S1. (A) Western blotting was performed for the indicated proteins in Tu212 and Bcl-2 overexpressing Tu212 (Tu212/Bcl-2) cell lines (upper panel) and in Tu686 and Bcl-2 overexpressing Tu686 (Tu686/Bcl-2) cell lines (lower panel) (B) Apoptosis analysis (error bars are mean � SD from 3 independent experiments) of indicated cell lines upon treatment with siC or siR2. Figure S2. (A) Western blotting was performed for the indicated proteins in H1299 and two clones of dominant negative p73 overexpressing H1299 (H1299/dN p73 cl-7 and cl-10) cell lines (upper panel) and in H358 dominant negative p73 overexpressing H358 (H358/dN) cell lines (lower panel). (B) Apoptosis analysis (error bars are mean � SD from 3 independent experiments) of indicated cell lines upon treatment with siC or siR2. Figure S3. (A) Western blotting was performed for the indicated proteins in A549 and Akt overexpressing A549 (A549/Akt) cell lines (upper panel) and in Tu686 and Akt overexpressing Tu686 (Tu686/Akt) cell lines (lower panel) (B) Apoptosis analysis (error bars are mean � SD from 3 independent experiments) of indicated cell lines upon treatment with siC or siR2. Figure S4. Gallery images of a z-stack. Tu212 cells were stained with anti-RRM2 (green), anti-Bcl-2 (red) and DAPI (blue). A z-stack of optical sections was created at 0.59 μm intervals using a confocal microscope (LSM 510; Carl Zeiss MicroImaging, Inc ) collected Inc.). A total of 32 images were collected, shown in a gallery of merged images collected in the z-stack in a single display. Figure S5. The relationship between RRM2 (IHC) and RRM2 (QD-IHF) in HNSCC. Spearman's correlation coefficient was estimated between RRM2 (IHC) and RRM2 (QD-IHF) expression level in tumor tissues from HNSCC patients. Figure S6. The relationship between RRM2 (IHC) and RRM2 (QD-IHF) in NSCLC. Spearman's correlation coefficient was estimated between RRM2 (IHC) and RRM2 (QD-IHF) expression levels in tumor tissues from NSCLC patients.
Supplementary Figure 2 from Adoptive Transfer of MART-1 T-Cell Receptor Transgenic Lymphocytes and Dendritic Cell Vaccination in Patients with Metastatic Melanoma
Authors: Chodon Thinle , Comin-Anduix Begoña , Chmielowski Bartosz , Koya Richard C. , Wu Zhongqi , Auerbach Martin , Ng Charles , Avramis Earl , Seja Elizabeth , Villanueva Arturo , McCannel Tara A. , Ishiyama Akira , Czernin Johannes , Radu Caius G. , Wang Xiaoyan , Gjertson David W. , Cochran Alistair J. , Cornetta Kenneth , Wong Deborah J.L. , Kaplan-Lefko Paula , Hamid Omid , Samlowski Wolfram , Cohen Peter A. , Daniels Gregory A. , Mukherji Bijay , Yang Lili , Zack Jerome A. , Kohn Donald B. , Heath James R. , Glaspy John A. , Witte Owen N. , Baltimore David , Economou James S. , Ribas Antoni
Published: April 2023

PDF file - 128KB, Transduction efficiencies of infused transgenic cells.
Supplementary Table 2 from Genome-Wide Study of Hypomethylated and Induced Genes in Patients with Liver Cancer Unravels Novel Anticancer Targets
Authors: Stefanska Barbara , Cheishvili David , Suderman Matthew , Arakelian Ani , Huang Jian , Hallett Michael , Han Ze-Guang , Al-Mahtab Mamun , Akbar Sheikh Mohammad Fazle , Khan Wasif Ali , Raqib Rubhana , Tanvir Imrana , Khan Haseeb Ahmed , Rabbani Shafaat A. , Szyf Moshe
Published: April 2023

PDF file - 71KB, Supplementary Table S2. A list of kinases whose phosphorylation was examined in SkHep1 liver cancer cells after RASAL2, NENF or combined RASAL2 and NENF depletion. The level of phosphorylation is expressed as a percentage of phosphorylation in the control - cells transfected with scrambled siRNA. Phosphorylation of a panel of 26 kinases was assessed using Proteome Profiler Array (R&D Systems Inc., MN, USA).
Supplementary Figures 1 - 2 from Identification of Serum Proton NMR Metabolomic Fingerprints Associated with Hepatocellular Carcinoma in Patients with Alcoholic Cirrhosis
Authors: Nahon Pierre , Amathieu Roland , Triba Mohamed N. , Bouchemal Nadia , Nault Jean-Charles , Ziol Marianne , Seror Olivier , Dhonneur Gilles , Trinchet Jean-Claude , Beaugrand Michel , Le Moyec Laurence
Published: April 2023

PDF file - 150K, 1H NMR spectra and 1H-1H Total Correlation Spectroscopy 2D NMR spectra. Typical 1H NMR (500 MHz) spectra of the region between 0 and 6 ppm from cirrhotic patient and 1H-1H Total Correlation Spectroscopy 2D NMR spectra of cirrhotic patient sera of the region between 0 and 6 ppm
Supplementary Figure 8 from Genome-Wide Study of Hypomethylated and Induced Genes in Patients with Liver Cancer Unravels Novel Anticancer Targets
Authors: Stefanska Barbara , Cheishvili David , Suderman Matthew , Arakelian Ani , Huang Jian , Hallett Michael , Han Ze-Guang , Al-Mahtab Mamun , Akbar Sheikh Mohammad Fazle , Khan Wasif Ali , Raqib Rubhana , Tanvir Imrana , Khan Haseeb Ahmed , Rabbani Shafaat A. , Szyf Moshe
Published: April 2023

PDF file - 685KB, Supplementary Figure S8. Expression of different RASAL2 transcript variants in liver cancer cells and normal hepatocytes. (A,B) Expression of RASAL2 as measured by QPCR using primers specific to transcript variant 1 and specific to variant 2 in HepG2 cells (A) and normal hepatocytes (NorHep, B) upon treatment with 1.0 microM 5-azaCdR. (C) Expression of different RASAL2 isoforms in liver cancer cells and NorHep. All results represent mean � S.D. of two or three independent experiments - ***P < 0.001, **P < 0.01, *P < 0.05.
Supplementary Figure 2 from Genome-Wide Study of Hypomethylated and Induced Genes in Patients with Liver Cancer Unravels Novel Anticancer Targets
Authors: Stefanska Barbara , Cheishvili David , Suderman Matthew , Arakelian Ani , Huang Jian , Hallett Michael , Han Ze-Guang , Al-Mahtab Mamun , Akbar Sheikh Mohammad Fazle , Khan Wasif Ali , Raqib Rubhana , Tanvir Imrana , Khan Haseeb Ahmed , Rabbani Shafaat A. , Szyf Moshe
Published: April 2023

PDF file - 492KB, Supplementary Figure S2. (A) Effect of 5-azaCdR at 1.0 microM concentration on non-transformed NorHep cell growth throughout 20 day-treatment. NorHep cells were seeded at a density of 3 x 105 per a 10-cm tissue culture dish. The medium was replaced with fresh medium containing 1.0 microM 5-azaCdR every 24 h for 3 days and every 48 h for the following 17 days (20 days in total). During the experiment the cells were split every 4-5 days after reaching 80 percent confluence and counted on day 3, 6, 9, 12, 14, and 20. (B-D) Expression and methylation levels of RASAL2 and NENF in NorHep after 1 microM 5-azaCdR treatment for 3 (3d) or 20 days (20d). Relative expression is expressed as a percentage of expression in control non-treated cells. Average methylation state of CpG sites was determined by pyrosequencing in control and treated cells for NENF after 3 days of exposure and for RASAL2 after 20 days (no changes were observed after 3 days as shown in Supplementary Figure S1). All results represent mean � S.D. of two or three independent experiments - ***P < 0.001, **P < 0.01, *P < 0.05.
Supplementary Movie 2A from Exploratory Clinical Trial of (4S)-4-(3-[18F]fluoropropyl)-l-glutamate for Imaging xC− Transporter Using Positron Emission Tomography in Patients with Non–Small Cell Lung or Breast Cancer
Authors: Baek Sora , Choi Chang-Min , Ahn Sei Hyun , Lee Jong Won , Gong Gyungyub , Ryu Jin-Sook , Oh Seung Jun , Bacher-Stier Claudia , Fels Lüder , Koglin Norman , Hultsch Christina , Schatz Christoph A. , Dinkelborg Ludger M. , Mittra Erik S. , Gambhir Sanjiv S. , Moon Dae Hyuk
Published: April 2023

AVI, 146K, Maximum intensity projection of 18FFDG in a breast cancer patient (Patient 13).
Supplementary Figure Legend, Tables 1 - 2 from Growth and Activation of Natural Killer Cells Ex Vivo from Children with Neuroblastoma for Adoptive Cell Therapy
Authors: Liu Yin , Wu Hong-Wei , Sheard Michael A. , Sposto Richard , Somanchi Srinivas S. , Cooper Laurence J.N. , Lee Dean A. , Seeger Robert C.
Published: April 2023

PDF file - 89K, Supplemental Table 1. List of antibodies used in this study. Supplemental table 2. Cytokines/chemokines excluded from the Luminex� panels.
Supplementary Figure Legend from Exploratory Clinical Trial of (4S)-4-(3-[18F]fluoropropyl)-l-glutamate for Imaging xC− Transporter Using Positron Emission Tomography in Patients with Non–Small Cell Lung or Breast Cancer
Authors: Baek Sora , Choi Chang-Min , Ahn Sei Hyun , Lee Jong Won , Gong Gyungyub , Ryu Jin-Sook , Oh Seung Jun , Bacher-Stier Claudia , Fels Lüder , Koglin Norman , Hultsch Christina , Schatz Christoph A. , Dinkelborg Ludger M. , Mittra Erik S. , Gambhir Sanjiv S. , Moon Dae Hyuk
Published: April 2023

PDF file, 76K, includes movie legends.
Supplementary Figure Legend from Aberrant Expression of Mucin Core Proteins and O-Linked Glycans Associated with Progression of Pancreatic Cancer
Authors: Remmers Neeley , Anderson Judy M. , Linde Erin M. , DiMaio Dominick J. , Lazenby Audrey J. , Wandall Hans H. , Mandel Ulla , Clausen Henrik , Yu Fang , Hollingsworth Michael A.
Published: April 2023

PDF file - 25K
Supplementary Figure 1 from Aberrant Expression of Mucin Core Proteins and O-Linked Glycans Associated with Progression of Pancreatic Cancer
Authors: Remmers Neeley , Anderson Judy M. , Linde Erin M. , DiMaio Dominick J. , Lazenby Audrey J. , Wandall Hans H. , Mandel Ulla , Clausen Henrik , Yu Fang , Hollingsworth Michael A.
Published: April 2023

PDF file - 248K, Supplementary Figure 1. (A) Simplified schematic of mucin type O-glycans analyzed in this report. Mucin-type O-linked glycans are initiated by the addition of an N-acetyl galactose sugar residue (the Tn epitope), which can be extended into the T antigen or core 3 structures, or Tn can be sialylated creating terminal STn that cannot be further extended. T antigen can be extended into core 2 structures that lead to the Lewis Blood Group antigens - LeX, SLeX, SLeC and sialyl Lewis A (the CA19-9 antigen, a widely utilized biomarker of adenocarcinoma progression). B & C - Representative immunohistochemical results for comparison of expression of mucin core proteins, glycans, and glycopeptides taken at 200x magnification. (B) Serial sections of primary tumor from autopsy patient 3 stained for indicated antigens. (C) Serial sections of liver metastasis from autopsy patient 20 for same antigens seen in primary tumor.
Supplementary Figure 2 from Number of Target Lesions for EASL and Modified RECIST to Predict Survivals in Hepatocellular Carcinoma Treated with Chemoembolization
Authors: Kim Beom Kyung , Kim Seung Up , Kim Myeong-Jin , Kim Kyung Ah , Kim Do Young , Park Jun Yong , Ahn Sang Hoon , Han Kwang-Hyub , Chon Chae Yoon
Published: April 2023

PDF file - 52K, Intra-individual agreement rates for target (A) and overall (B) response using EASL criteria and intra-individual agreement rates for target (C) and overall (D) response using mRECIST
Supplementary Table 4 from Relationship of Mammographic Density and Gene Expression: Analysis of Normal Breast Tissue Surrounding Breast Cancer
Authors: Sun Xuezheng , Gierach Gretchen L. , Sandhu Rupninder , Williams Tyisha , Midkiff Bentley R. , Lissowska Jolanta , Wesolowska Ewa , Boyd Norman F. , Johnson Nicole B. , Figueroa Jonine D. , Sherman Mark E. , Troester Melissa A.
Published: April 2023

Supplementary Table 4 - XLSX file 52K, Gene ID and corresponding standard vector of the biologically relevant signatures
Supplementary Table 2 from Relationship of Mammographic Density and Gene Expression: Analysis of Normal Breast Tissue Surrounding Breast Cancer
Authors: Sun Xuezheng , Gierach Gretchen L. , Sandhu Rupninder , Williams Tyisha , Midkiff Bentley R. , Lissowska Jolanta , Wesolowska Ewa , Boyd Norman F. , Johnson Nicole B. , Figueroa Jonine D. , Sherman Mark E. , Troester Melissa A.
Published: April 2023

Supplementary Table 2 - XLSX file 159KB, Gene list of the Active signature
Supplementary Figure 5 from Myeloid Differentiation Factor 88 Promotes Growth and Metastasis of Human Hepatocellular Carcinoma
Authors: Liang Beibei , Chen Rui , Wang Tao , Cao Lei , Liu Yingying , Yin Fan , Zhu Minhui , Fan Xiaoyu , Liang Yingchao , Zhang Lu , Guo Yajun , Zhao Jian
Published: April 2023

PDF File - 444K, HCC cells expressed low level of TLRs (Toll-like receptors) and relative high level IL-1R compared with that in normal liver cell line HL7702. And alterations in the Ras pathway in HCC cells showed that Ras pathway and MyD88 expression is not related in HCC cells.
Supplementary Table 1 from Having Pancreatic Cancer with Tumoral Loss of ATM and Normal TP53 Protein Expression Is Associated with a Poorer Prognosis
Authors: Kim Haeryoung , Saka Burcu , Knight Spencer , Borges Michael , Childs Erica , Klein Alison , Wolfgang Christopher , Herman Joseph , Adsay Volkan N. , Hruban Ralph H. , Goggins Michael
Published: April 2023

PDF file - 123KB, PCR and sequencing primer sequences.
Supplementary Figure 2 from Myeloid Differentiation Factor 88 Promotes Growth and Metastasis of Human Hepatocellular Carcinoma
Authors: Liang Beibei , Chen Rui , Wang Tao , Cao Lei , Liu Yingying , Yin Fan , Zhu Minhui , Fan Xiaoyu , Liang Yingchao , Zhang Lu , Guo Yajun , Zhao Jian
Published: April 2023

PDF File - 1518K, The level of MyD88 in HL7702 was markedly elevated by the stimulation of LPS, IL-1� or IL-1� and MyD88 was overexpressed or depleted significantly compared to their controls after transfected with pMyD88 or shMyD88.
Supplementary Tables 1 - 4 from Dual Targeting of mTOR and Aurora-A Kinase for the Treatment of Uterine Leiomyosarcoma
Authors: Brewer Savannah Kari J. , Demicco Elizabeth G. , Lusby Kristelle , Ghadimi Markus PH. , Belousov Roman , Young Eric , Zhang Yiqun , Huang Kai-Lieh , Lazar Alexander J. , Hunt Kelly K. , Pollock Raphael E. , Creighton Chad J. , Anderson Matthew L. , Lev Dina
Published: April 2023

PDF file, 39K, Table S1: correlation between biomarker expression and tumor status; Table S2: correlation between mTOR associated biomarkers' expression; Table S3: univariable and multivariable Cox analyses for biomarker expression correlation with ULMS patients outcome; Table S4: averaged fraction affected, combination index, averages and standard deviation values for in vitro synergy experiments.
Supplementary Methods from Dual Targeting of mTOR and Aurora-A Kinase for the Treatment of Uterine Leiomyosarcoma
Authors: Brewer Savannah Kari J. , Demicco Elizabeth G. , Lusby Kristelle , Ghadimi Markus PH. , Belousov Roman , Young Eric , Zhang Yiqun , Huang Kai-Lieh , Lazar Alexander J. , Hunt Kelly K. , Pollock Raphael E. , Creighton Chad J. , Anderson Matthew L. , Lev Dina
Published: April 2023

PDF file, 39K, Supplemental Materials and Methods (TMA immunohistochemistry, cell culture and reagents, cellular assays, and xenograft immunostaining).
Supplementary Figures 1 - 3 from Dual Targeting of mTOR and Aurora-A Kinase for the Treatment of Uterine Leiomyosarcoma
Authors: Brewer Savannah Kari J. , Demicco Elizabeth G. , Lusby Kristelle , Ghadimi Markus PH. , Belousov Roman , Young Eric , Zhang Yiqun , Huang Kai-Lieh , Lazar Alexander J. , Hunt Kelly K. , Pollock Raphael E. , Creighton Chad J. , Anderson Matthew L. , Lev Dina
Published: April 2023

PDF file, 483K, Fig S1: Heat map representation of mTOR activation in ULMS; Fig S2: results of Combination Index analyses; Fig S3: results of repeat animal experiment.
Supplementary figures from TIE-2 and VEGFR Kinase Activities Drive Immunosuppressive Function of TIE-2–Expressing Monocytes in Human Breast Tumors
Authors: Ibberson Mark , Bron Sylvian , Guex Nicolas , Faes-van't Hull Eveline , Ifticene-Treboux Assia , Henry Luc , Lehr Hans-Anton , Delaloye Jean-François , Coukos George , Xenarios Ioannis , Doucey Marie-Agnès
Published: April 2023

Supplementary figures - PDF file 1536K, Figure S1. Proliferation of tumor-specific CD4 T cells by matured DC pulsed with autologous tumor lysate; Figure S2. In breast tumors TEM and CD11c+ are distinct cell subsets
Supplementary Table 5 from Functional Analysis of Genes in Regions Commonly Amplified in High-Grade Serous and Endometrioid Ovarian Cancer
Authors: Davis Sally J. , Sheppard Karen E. , Pearson Richard B. , Campbell Ian G. , Gorringe Kylie L. , Simpson Kaylene J.
Published: April 2023

PDF file - 81K, All screening hits
Supplementary Table 3 from Functional Analysis of Genes in Regions Commonly Amplified in High-Grade Serous and Endometrioid Ovarian Cancer
Authors: Davis Sally J. , Sheppard Karen E. , Pearson Richard B. , Campbell Ian G. , Gorringe Kylie L. , Simpson Kaylene J.
Published: April 2023

PDF file - 89K, Boutique siRNA library
Supplementary Figure 2 from Gene Expression Profiling using Nanostring Digital RNA Counting to Identify Potential Target Antigens for Melanoma Immunotherapy
Authors: Beard Rachel E. , Abate-Daga Daniel , Rosati Shannon F. , Zheng Zhili , Wunderlich John R. , Rosenberg Steven A. , Morgan Richard A.
Published: April 2023

PDF file - 137K, Supplemental Figure S2. Hierarchical clustering of 27 genes that differentiate tumors from normal tissues with at least a two-fold higher expression in tumors.
Supplementary Figure 1 from Establishment and Validation of Circulating Tumor Cell–Based Prognostic Nomograms in First-Line Metastatic Breast Cancer Patients
Authors: Giordano Antonio , Egleston Brian L. , Hajage David , Bland Joseph , Hortobagyi Gabriel N. , Reuben James M. , Pierga Jean-Yves , Cristofanilli Massimo , Bidard Francois-Clement
Published: April 2023

PDF file - 51K, Calibration plots of PFS at (A) 6 months and (B) 2 years and OS at (C) 1 year and (D) 5 years in both cohorts. Cox predictions were averaged at 2 years within the quintiles of the ordered predictions. Within each quintile, the unadjusted probability of death using Kaplan-Meier survival estimators was estimated. We then plotted unadjusted versus model average predictions. The red line corresponds to the perfect prediction.
Supplementary Figure 1 from Downregulation of miR-452 Promotes Stem-Like Traits and Tumorigenicity of Gliomas
Authors: Liu Liping , Chen Kun , Wu Jueheng , Shi Ling , Hu Bo , Cheng Shiyuan , Li Mengfeng , Song Libing
Published: April 2023

Reduced miR-452 expression in gliomas correlates with poor prognosis.
Supplementary Figure Legend from Anti-HDGF Targets Cancer and Cancer Stromal Stem Cells Resistant to Chemotherapy
Authors: Zhao Jun , Ma Mark Z. , Ren Hening , Liu Zhenqiu , Edelman Martin J. , Pan Hong , Mao Li
Published: April 2023

Supplementary Figure Legend - PDF file 53K, legend for the supplemental figures
Supplementary Figure Legends from Prostate Cancer Progression Correlates with Increased Humoral Immune Response to a Human Endogenous Retrovirus GAG Protein
Authors: Reis Bernardo Sgarbi , Jungbluth Achim A. , Frosina Denise , Holz Megan , Ritter Erika , Nakayama Eiichi , Ishida Toshiaki , Obata Yuichi , Carver Brett , Scher Howard , Scardino Peter T. , Slovin Susan , Subudhi Sumit K. , Reuter Victor E. , Savage Caroline , Allison James P. , Melamed Jonathan , Jäger Elke , Ritter Gerd , Old Lloyd J. , Gnjatic Sacha
Published: April 2023

- PDF file 90K, Supplementary Figure Legends
Supplementary Table 3b from AIB1:ERα Transcriptional Activity Is Selectively Enhanced in Aromatase Inhibitor–Resistant Breast Cancer Cells
Authors: O'Hara Jane , Vareslija Damir , McBryan Jean , Bane Fiona , Tibbitts Paul , Byrne Christopher , Conroy Ronán M. , Hao Yuan , Gaora Peadar Ó , Hill Arnold D.K. , McIlroy Marie , Young Leonie S.
Published: April 2023

PDF file, 213KB, Supplementary Table 3b ER/AIB1 overlap genelist - partial ERE.
Supplementary Figure 2 from Prostate Cancer Progression Correlates with Increased Humoral Immune Response to a Human Endogenous Retrovirus GAG Protein
Authors: Reis Bernardo Sgarbi , Jungbluth Achim A. , Frosina Denise , Holz Megan , Ritter Erika , Nakayama Eiichi , Ishida Toshiaki , Obata Yuichi , Carver Brett , Scher Howard , Scardino Peter T. , Slovin Susan , Subudhi Sumit K. , Reuter Victor E. , Savage Caroline , Allison James P. , Melamed Jonathan , Jäger Elke , Ritter Gerd , Old Lloyd J. , Gnjatic Sacha
Published: April 2023

- PDF file 341K, qPCR gene expression analysis of chromosome 22q11.23 region in cancer tissues. Total RNA from cancer tissues was submitted to DNAse treatment and reverse transcriptase reaction for cDNA synthesis. The resulting cDNA was used on qPCR to detect the expression of GAG-HERV-K and the neighbor genes BCR, IGGL1, RGL4 and ZDHHC8P. The results are expressed as relative expression to GAG-HERV-K levels in normal prostate. GAG-HERV-K expression is relative to GAPDH. BCR, IGGL1, RGL4 and ZDHHC8P expression is relative to TFRC
Supplementary Table 2 from AIB1:ERα Transcriptional Activity Is Selectively Enhanced in Aromatase Inhibitor–Resistant Breast Cancer Cells
Authors: O'Hara Jane , Vareslija Damir , McBryan Jean , Bane Fiona , Tibbitts Paul , Byrne Christopher , Conroy Ronán M. , Hao Yuan , Gaora Peadar Ó , Hill Arnold D.K. , McIlroy Marie , Young Leonie S.
Published: April 2023

PDF file, 55KB, Supplementary table 2: Rate of incidence of disease recurrence according to AIB1, HER2, tumour grade, tumour size and nodal status in breast cancer patients treated with first-line AI.
Supplementary Figures 1 - 9 from AIB1:ERα Transcriptional Activity Is Selectively Enhanced in Aromatase Inhibitor–Resistant Breast Cancer Cells
Authors: O'Hara Jane , Vareslija Damir , McBryan Jean , Bane Fiona , Tibbitts Paul , Byrne Christopher , Conroy Ronán M. , Hao Yuan , Gaora Peadar Ó , Hill Arnold D.K. , McIlroy Marie , Young Leonie S.
Published: April 2023

PDF file, 320KB, Supplementary Figures 1-9 Supplementary Figure 1: Expression levels of aromatase in our cell lines and aromatase activity assay Supplementary Figure 2: Proliferation of Aro and LetR in response to treatment Supplementary Figure 3: Kaplan Meier estimates of disease free survival in the entire ER positive population Supplementary Figure 4:Interactions between ERalpha and AIB1 in letrozole sensitive Aro cells Supplementary Figure 5: Analysis of protein levels in Anastrozole resistant cell line (ANAR) Supplementary Figure 6: ChiP showing recruitment of ERalpha and AIB1 to distal region promoters Supplementary Figure 7: Basal protein levels of Myc and cyclinD1 protein and basal mRNA levels of pS2 Supplementary Figure 8:Effect of Lapatinib treatment on pS2 and Myc mRNA levels Supplementary Figure 9: Pathway analysis of ERalpha-AIB1 target genes.
Supplementary Tables 1 - 4 from MicroRNA Profiling Can Classify Acute Leukemias of Ambiguous Lineage as Either Acute Myeloid Leukemia or Acute Lymphoid Leukemia
Authors: de Leeuw David C. , van den Ancker Willemijn , Denkers Fedor , de Menezes Renée X. , Westers Theresia M. , Ossenkoppele Gert J. , van de Loosdrecht Arjan A. , Smit Linda
Published: April 2023

PDF file - 100K, Supplementary Table 1: Literature based signature; Supplemental Table 2: Flow cytometric and genetic characteristics of the patients with leukemia of ambiguous lineage; Supplementary Table 3: Significantly discriminative microRNAs between the myeloid and lymphoid cluster; Supplementary Table 4a-d: MicroRNAs differential expressed between leukemia of ambiguous lineage, AML, B-ALL and T-ALL samples analyzed by LIMMA
Supplementary Figure 2 from Prognostic and Predictive Values of the Immunoscore in Patients with Rectal Cancer
Authors: Anitei Maria-Gabriela , Zeitoun Guy , Mlecnik Bernhard , Marliot Florence , Haicheur Nacilla , Todosi Ana-Maria , Kirilovsky Amos , Lagorce Christine , Bindea Gabriela , Ferariu Dan , Danciu Mihai , Bruneval Patrick , Scripcariu Viorel , Chevallier Jean-Marc , Zinzindohoué Franck , Berger Anne , Galon Jérôme , Pagès Franck
Published: April 2023

To reinforce the confidence on the statistical analyses, patients with poor postoperative outcome (I0 and I1) were pooled. The Kaplanâ€“Meier curves illustrate the DFS according to the Immunoscore and show significant differences between patient groups. The multivariate analysis shows the prognostic power of the Immunoscore and illustrates how the Immunoscore overcomes the TNM scoring system.
Supplementary Figure 1 from Prognostic and Predictive Values of the Immunoscore in Patients with Rectal Cancer
Authors: Anitei Maria-Gabriela , Zeitoun Guy , Mlecnik Bernhard , Marliot Florence , Haicheur Nacilla , Todosi Ana-Maria , Kirilovsky Amos , Lagorce Christine , Bindea Gabriela , Ferariu Dan , Danciu Mihai , Bruneval Patrick , Scripcariu Viorel , Chevallier Jean-Marc , Zinzindohoué Franck , Berger Anne , Galon Jérôme , Pagès Franck
Published: April 2023

PDF file - 83KB, Kaplan Meier curves for the duration of OS according A, to T cell (CD3+) density evaluated in combined tumor regions (CT and IM). B, to T cell (CD8+) density evaluated in combined tumor regions (CT and IM).
Supplementary Figure 1 from Prognostic and Predictive Values of the Immunoscore in Patients with Rectal Cancer
Authors: Anitei Maria-Gabriela , Zeitoun Guy , Mlecnik Bernhard , Marliot Florence , Haicheur Nacilla , Todosi Ana-Maria , Kirilovsky Amos , Lagorce Christine , Bindea Gabriela , Ferariu Dan , Danciu Mihai , Bruneval Patrick , Scripcariu Viorel , Chevallier Jean-Marc , Zinzindohoué Franck , Berger Anne , Galon Jérôme , Pagès Franck
Published: April 2023

Kaplan Meier curves for the duration of OS according A: to T cell (CD3+) density evaluated in combined tumor regions (CT and IM). B: to T cell (CD8+) density evaluated in combined tumor regions (CT and IM).
Supplementary Figure Legends 1-5, Table Legend 1 from Alternative Cleavage and Polyadenylation during Colorectal Cancer Development
Authors: Morris Adam R. , Bos Arnold , Diosdado Begoña , Rooijers Koos , Elkon Ran , Bolijn Anne S. , Carvalho Beatriz , Meijer Gerrit A. , Agami Reuven
Published: April 2023

PDF file - 24K
Supplementary Figure 5 from Alternative Cleavage and Polyadenylation during Colorectal Cancer Development
Authors: Morris Adam R. , Bos Arnold , Diosdado Begoña , Rooijers Koos , Elkon Ran , Bolijn Anne S. , Carvalho Beatriz , Meijer Gerrit A. , Agami Reuven
Published: April 2023

PDF file - 87K, 3'PCR of proximal and distal PASs isoforms in relation to beta-actin. *p<10-2, **p<10-3, ***p<10-4. Only values of p<10-2 are shown.
Supplementary Figure 4 from Alternative Cleavage and Polyadenylation during Colorectal Cancer Development
Authors: Morris Adam R. , Bos Arnold , Diosdado Begoña , Rooijers Koos , Elkon Ran , Bolijn Anne S. , Carvalho Beatriz , Meijer Gerrit A. , Agami Reuven
Published: April 2023

PDF file - 580K, 3'PCR analysis of APA events in tissue subtypes. A=adenoma without chromosomal aberrations, Adenoma +Ab.=adenoma with chromosomal aberrations, MSS=microsatellite stable, MSI=microsatellite instable. *p<10-2, **p<10-3, ***p<10-4. Only values of p<10-2 are shown.
Supplementary Figure Legends from Overcoming IGF1R/IR Resistance through Inhibition of MEK Signaling in Colorectal Cancer Models
Authors: Flanigan Sara A. , Pitts Todd M. , Newton Timothy P. , Kulikowski Gillian N. , Tan Aik Choon , McManus Martine C. , Spreafico Anna , Kachaeva Maria I. , Selby Heather M. , Tentler John J. , Eckhardt S. Gail , Leong Stephen
Published: April 2023

Supplementary Figure Legends - PDF file 41K, Supplementary Figure Legends
Supplementary Figure 9 from Overcoming IGF1R/IR Resistance through Inhibition of MEK Signaling in Colorectal Cancer Models
Authors: Flanigan Sara A. , Pitts Todd M. , Newton Timothy P. , Kulikowski Gillian N. , Tan Aik Choon , McManus Martine C. , Spreafico Anna , Kachaeva Maria I. , Selby Heather M. , Tentler John J. , Eckhardt S. Gail , Leong Stephen
Published: April 2023

Supplementary Figure 9 - PDF file 83K, CRC PDTX Treated with OSI906 and AZD6244
Supplementary Figure 6 from Overcoming IGF1R/IR Resistance through Inhibition of MEK Signaling in Colorectal Cancer Models
Authors: Flanigan Sara A. , Pitts Todd M. , Newton Timothy P. , Kulikowski Gillian N. , Tan Aik Choon , McManus Martine C. , Spreafico Anna , Kachaeva Maria I. , Selby Heather M. , Tentler John J. , Eckhardt S. Gail , Leong Stephen
Published: April 2023

Supplementary Figure 6 - PDF file 79K, Densitometry Analysis of Westerns
Supplementary Figure 5 from Overcoming IGF1R/IR Resistance through Inhibition of MEK Signaling in Colorectal Cancer Models
Authors: Flanigan Sara A. , Pitts Todd M. , Newton Timothy P. , Kulikowski Gillian N. , Tan Aik Choon , McManus Martine C. , Spreafico Anna , Kachaeva Maria I. , Selby Heather M. , Tentler John J. , Eckhardt S. Gail , Leong Stephen
Published: April 2023

Supplementary Figure 5 - PDF file 116K, Caspase 3/7 Activity
Supplementary Figure 4 from Overcoming IGF1R/IR Resistance through Inhibition of MEK Signaling in Colorectal Cancer Models
Authors: Flanigan Sara A. , Pitts Todd M. , Newton Timothy P. , Kulikowski Gillian N. , Tan Aik Choon , McManus Martine C. , Spreafico Anna , Kachaeva Maria I. , Selby Heather M. , Tentler John J. , Eckhardt S. Gail , Leong Stephen
Published: April 2023

Supplementary Figure 4 - PDF file 158K, Table of CI values
Supplementary Figure 3 from Overcoming IGF1R/IR Resistance through Inhibition of MEK Signaling in Colorectal Cancer Models
Authors: Flanigan Sara A. , Pitts Todd M. , Newton Timothy P. , Kulikowski Gillian N. , Tan Aik Choon , McManus Martine C. , Spreafico Anna , Kachaeva Maria I. , Selby Heather M. , Tentler John J. , Eckhardt S. Gail , Leong Stephen
Published: April 2023

Supplementary Figure 3 - PDF file 91K, Combination Fraction Inhibited Graphs
Supplementary Table 1 from HDAC Inhibitors Enhance T-Cell Chemokine Expression and Augment Response to PD-1 Immunotherapy in Lung Adenocarcinoma
Authors: Zheng Hong , Zhao Weipeng , Yan Cihui , Watson Crystina C. , Massengill Michael , Xie Mengyu , Massengill Chris , Noyes David R. , Martinez Gary V. , Afzal Roha , Chen Zhihua , Ren Xiubao , Antonia Scott J. , Haura Eric B. , Ruffell Brian , Beg Amer A.
Published: April 2023

Supplementary Table 1. LD50 concentrations of different agents (determined at 48h) are indicated. Also shown are agents used at 10muM.
Supplementary Table 2 from Recognition and Killing of Autologous, Primary Glioblastoma Tumor Cells by Human Cytomegalovirus pp65-Specific Cytotoxic T Cells
Authors: Nair Smita K. , De Leon Gabriel , Boczkowski David , Schmittling Robert , Xie Weihua , Staats Janet , Liu Rebecca , Johnson Laura A. , Weinhold Kent , Archer Gary E. , Sampson John H. , Mitchell Duane A.
Published: April 2023

PDF file - 72KB, Phenotype of in vitro stimulated T cells.
Supplementary Figure 2 from Recognition and Killing of Autologous, Primary Glioblastoma Tumor Cells by Human Cytomegalovirus pp65-Specific Cytotoxic T Cells
Authors: Nair Smita K. , De Leon Gabriel , Boczkowski David , Schmittling Robert , Xie Weihua , Staats Janet , Liu Rebecca , Johnson Laura A. , Weinhold Kent , Archer Gary E. , Sampson John H. , Mitchell Duane A.
Published: April 2023

PDF file - 277KB, Phenotypic analysis of CMV pp65 RNA-pulsed DCs.
Supplementary Figure 1 from Recognition and Killing of Autologous, Primary Glioblastoma Tumor Cells by Human Cytomegalovirus pp65-Specific Cytotoxic T Cells
Authors: Nair Smita K. , De Leon Gabriel , Boczkowski David , Schmittling Robert , Xie Weihua , Staats Janet , Liu Rebecca , Johnson Laura A. , Weinhold Kent , Archer Gary E. , Sampson John H. , Mitchell Duane A.
Published: April 2023

PDF file - 65KB, Analysis of maturation markers in dendritic cells pulsed with RNA and cultured in maturation cytokine cocktail.
Supplementary Figure 2 from Thalidomide in Total Therapy 2 Overcomes Inferior Prognosis of Myeloma with Low Expression of the Glucocorticoid Receptor Gene NR3C1
Authors: Heuck Christoph J. , Szymonifka Jackie , Hansen Emily , Shaughnessy John D. , Usmani Saad Z. , van Rhee Frits , Anaissie Elias , Nair Bijay , Waheed Sarah , Alsayed Yazan , Petty Nathan , Bailey Clyde , Epstein Joshua , Hoering Antje , Crowley John , Barlogie Bart
Published: April 2023

PDF file, 297K, Survival outcomes in Total Therapy 2 according to randomization to control arm (-T) or thalidomide (+T).
Figure S5 from Interobserver Agreement in Describing the Ultrasound Appearance of Adnexal Masses and in Calculating the Risk of Malignancy Using Logistic Regression Models
Authors: Sladkevicius Povilas , Valentin Lil
Published: April 2023

Figure S5. Relationship between number of days between the two examinations and inter-observer difference in height of the largest papillary projections in benign and malignant tumors is shown on this scatterplot
Data Supplement from Sonic Hedgehog Paracrine Signaling Activates Stromal Cells to Promote Perineural Invasion in Pancreatic Cancer
Authors: Li Xuqi , Wang Zheng , Ma Qingyong , Xu Qinhong , Liu Han , Duan Wanxing , Lei Jianjun , Ma Jiguang , Wang Xiu , Lv Shifang , Han Liang , Li Wei , Guo Jian , Guo Kun , Zhang Dong , Wu Erxi , Xie Keping
Published: April 2023

Supplementary materials and methods, including immunohistochemistry, cell culture, separation of dorsal root ganglions and co-culture, subcutaneous injections in athymic nude mice, in vivo model of tumor sciatic neural invasion, and others.