bluuebunny/crossref_metadata_2025 huggingface dataset:
Isolation of Human Monoclonal scfv Antibody Specifically Recognizing the D2-5-Ht1a Heteromer.
Authors: Łukasiewicz Sylwia , Fic Ewelina , Bzowska Monika , Dziedzicka-Wasylewska Marta
Published: April 2019

Antibody phage display has become a useful technique for discovering and optimizing target-specific monoclonal antibodies suitable for many applications, including therapeutic ligands, which may act as direct pharmacological compounds or may be used as targeting ligands for controlled drug delivery. Recently, the D2-5-HT1A heteromer, which is formed by the dopamine D2 and serotonin 5-HT1A receptors has attracted attention as a potential target of antipsychotic drugs. Therefore, the aim of the study was to identify scFv monoclonal antibodies that are able to specifically recognize epitopes formed within the heteromer structure. Because both receptors are membrane proteins, it is important to conduct bio-panning experiments in the most natural conditions, in which the presented antigens (D2-5-HT1A heteromers) are in their native form and possibly in their best-preserved spatial structure. It has been shown here that phage display methodology can be successfully used in the preparation of monoclonal antibodies against dimers of membrane proteins. To separate phages specifically binding the D2-5-HT1A heteromer, the selection process using CHO+ cells with overexpression of both receptors was conducted. Phages that were bound to receptor monomers or other CHO-K1 cell surface proteins were eliminated as a result of negative selection by using CHO- cells expressing separate receptor monomers.
Histologic Remission in Ulcerative Colitis: Are We There Yet?
Authors: Long Millie D. , Rubin David T.
Published: April 2019

As the field of inflammatory bowel disease moves toward treating to a “target” that includes mucosal healing, better outcome definitions are needed. One important question is whether the definition of mucosal healing should include “histologic” remission. In this systematic review and meta-analysis, the authors describe histologic healing rates of medical therapies for ulcerative colitis in randomized controlled trials. Although observational data demonstrate that histologic remission has consistently been associated with improved outcomes, we argue that there is a great deal of work left to be done before we can embrace a histologic endpoint of management in ulcerative colitis.
Quem é mulher? Que mulher? Que mulheres?
Authors: Borges Dulcina Tereza Bonati , Carneiro Maria Elizabeth Ribeiro
Published: April 2019

As perspectivas que acionam os movimentos feministas na história buscam transformar a vida das mulheres e contestar as definições do feminino que são produzidas da sociedade, ou ainda, reler as posições do feminino que circulam na cultura. No jogo discursivo das ciências, da política, da arte, em suma, do mundo social, as experiências das mulheres, de modo geral, emergem em representações para evidenciar e naturalizar a localização inferiorizada do feminino em relação ao masculino.
SUFRÃGIO À BRASILEIRA: uma leitura Pós-Colonial do Feminismo no século XIX
Authors: E Silva Rebecca Corrêa , Pedro Joana Maria
Published: April 2019

ResumoO presente estudo discute as relações entre feminismo e positivismo na obraÂ teorias da modernidade e da pós-modernidade. Buscamos analisar a contribuição do pensamento de Nísia para a emancipação das mulheres no Brasil, ao mesmo tempo em que procuramos localizar as origens do movimento feminista brasileiro à luz do atual referencial teórico das abordagens pós-coloniais feministas do Sul global. Desta forma, entendemos que um dos caminhos possíveis para a compreensão do surgimento do feminismo no Brasil passa de Nísia Floresta, intelectual e defensora dos direitos da mulher brasileira no século XIX. Trata-se de uma pesquisa embasada em revisão bibliográfica que intenta estabelecer um diálogo entre as pela revisão das formas de apropriação das ideias de matriz europeia naquele período, tais como o feminismo e o positivismo.Palavras-chave: Feminismo. Positivismo. Pós-colonialismo. BRAZILIAN SUFFRAGE:Â an overview of postcolonial feminism in the nineteenth centuryAbstract This article presents Nísia Floresta Ìs work, an intellectual scholar and advocate of the Brazilian woman rights in the nineteenth century, regarding the relation between feminism and positivism. Considering as an initial survey, based on bibliographic revision of dialogues with modernity and post-modern theories, we used authors that focused on feminism history of the "first wave" in Brazil. At the same time, we searched about the position of Brazilian feminism origins via the Latin-American theoretical background from the post-colonialist feminist approaches, by South global. Therefore, we recognize that one of the possible paths in understanding the Brazilian feminism of the "first wave" entails the review of appropriation of ideas based on the European origins, such as feminism and positivism. Keywords: Feminism. Positivism. Post-colonialism.Â
O EMPODERAMENTO DE DELEGADAS DA POLÍCIA CIVIL NA ÓTICA DA VIOLÊNCIA SIMBÓLICA
Authors: Pinto Rosilaine Aparecida , Melo Marlene Catarina de Oliveira Lopes
Published: April 2019

Resumo Este artigo tem por objetivo analisar como se configura o empoderamento de delegadas da Polícia Civil, na ótica da violência simbólica, com base no modelo de análise do processo de empoderamento proposto por Melo (2012). Palavras-Chave: Empoderamento. Violência Simbólica. Gênero. Delegadas. THE EMPOWERMENT OF CIVIL POLICE DELEGATES SEEN THROUGH THE CONCEPT OF SYMBOLIC VIOLENCE Abstract The present article present an approach of how the empowerment of civil police delegates can be seen through the concept of symbolic violence, particularly according to the empowerment process analysis proposed by Melo (2012). Keywords: Empowerment. Symbolic Violence. Gender. Delegates.Â
TRAMAR, DESTRAMAR E RETRAMAR: a arte nas montanhas das Minas Gerais
Authors: Castro Amanda Motta
Published: April 2019

Resumo O artigo é um extrato da pesquisa de doutorado sobre o processo pedagógico de ensinar e aprender da tecelagem manual desenvolvido em Resende Costa, cidade localizada nas montanas de Minhas Gerais onde a grande maioria das pessoas sobrevive da tecelagem manual. Neste lugar um dito popular, ouvido muitas vezes durante a pesquisa empírica, revela: "Em Resende Costa, em todas as casas existe um tearâ€. A economia do município gira em torno das 98 lojas de artesanato. A metodologia da investigação com base em pesquisa participante, foi realizada por meio de entrevistas semiestruturadas, observação participante e diário de campo. A análise dos dados foi embasada na hermenêutica feminista. Entre os resultados encontrados, observa-se a formação das tecelãs que se desenvolve pelas mulheres da localidade, sobretudo pelas mãos das mulheres mais velhas, que realizam o repasse, criando, assim, o processo de ensinar e aprender da tecelagem manual e suas invisibilidades. Palavras-chave: Estudos feministas. Educação popular. Gênero. Formação. Artesanato. Tecelagem. TRAMING, DESTRAMING AND RETRAMING: art in the mountains of Minas Gerais Abstract A result of my Doctoral Dissertation defended in 2015, this paper seeks to analyze how the pedagogical process of teaching and learning hand weaving developed in Resende Costa town occurs. In this small town in the state of Minas Gerais, Brazil, most people live out of hand weaving. In this place, they frequently repeated: "In Resende Costa there is a loom at every homeâ€. In this sense, the economy of the town revolves around its 98 handcrafting stores. Methodology employed based on the participatory research method was carried out with semi-structured interviews, participant observation, and field diary. The data analysis was based on feminist hermeneutics. Among the outcomes, we see the female weavers' training beeing developed by local women,Â mainly by the hand of older ones that pass around their knowledge and, thus, creating a process of teaching and learning of hand weaving and their invisibility.Keywords: Feminist Studies. Popular Education. Genre. Training. Handicraft, Weaving.Â
CATÃLOGOS OU CATALOGADAS? Uma reflexão sobre a representação feminina em catálogos fitness
Authors: Hengen Liandra Fátima , Araújo Denise Castilhos De
Published: April 2019

Resumo O artigo propõe uma reflexão sobre a imagem de mulheres construídas em marcas de roupas fitness e seus catálogos. Rala Bela e DiCorpo exercem papel fundamental na venda dos produtos e, também, constroem representações e reiteram estereótipos de beleza. Considera-se que o corpo físico pode estar sujeito às influências dessas marcas que sugerem um padrão corporal de beleza para suas consumidoras. O corpo feminino, nesses anúncios, também pode ser considerado como um produto que, indiretamente, também está Ã  venda ou pronto para consumo. Nele, prospectam-se medidas, instrumentos e efeitos dos atuais padrões estéticos. Para este estudo, partiu-se de uma revisão bibliográfica acerca de conceitos tais como corpo (GOLDENBERG, 2007), beleza (WOLF, 1992) e representação (WOODWARD, 2014; HALL, 2006), a fim de realizar a reflexão pretendida. Palavras-chave: Representação. Mulheres. Beleza. Catálogos fitness. CATALOGUES OR CATALOGUED? A reflection about female representation in fitness catalogues Abstract The article proposes an approach of the image of women represented by brands of fitness clothes in their catalogues. Rala Bela and DiCorpo perform a fundamental role in the selling of products, also building/reiterating some beauty stereotypes. It has been considered that physical body may be liable to be influenced by brands that suggest a corporal beauty standard for their consumers. The female body, in the advertisements, may also be considered as a product, indirectly, ready for sale or consume. Measures are prospected, as instruments and effects of the current aesthetic standards. This study is based on concepts such as body (GOLDENBERG, 2007), beauty (WOLF, 1992) and representation (WOODWARD, 2014; HALL, 2006), in order to realize the reflection intended. Keywords: Representation. Women. Beauty. Fitness Catalogues.Â
A Secretaria Especial de Políticas para as Mulheres: a questão de gênero vista de forma bidimensional
Authors: Altoé André Pizetta , Silva Marinete Dos Santos
Published: April 2019

ResumoEste artigo tece algumas considerações sobre como a criação da Secretaria Especial de Políticas Públicas para as Mulheres inaugura uma abordagem bidimensional nas políticas públicas que buscam combater as desigualdades de gênero no Brasil. Palavras-chave: Políticas Públicas para as Mulheres. Desigualdade de Gé‚nero. Feminismo.Abstract This article presents some considerations about how the creation of the Special Secretariat for Public Policies for Women inaugurates a two - dimensional approach in public policies that seek to combat gender inequalities in Brazil. Keywords: Public Policies for Women. Gender Inequality. Feminism.Â
Considerações sobre a figura da mulher abastada no livro O castigo da prostituição, publicado no período joanino (1808-1821)
Authors: Oliveira Anelise Martinelli Borges
Published: April 2019

Resumo Objetiva-se compreender a figura da mulher abastada presente no livro O castigo da prostituição, - publicado no Rio de Janeiro em 1815. Conclui-se que as prescrições contidas no mesmo vão de encontro com a concepção que se tinha da mulher de elite durante o Período Joanino (1808-1821). Palavras-chave: O castigo da prostituição. Mulher Abastada. Período Joanino.Considerations on figure women's wealthy in O castigo da prostituição,Â published on período joanino (1808-1821)Abstract The objective is to understand the figure of the wealthy woman present in the book The punishment of prostitution, published in Rio de Janeiro in 1815. It is concluded that the prescriptions contained therein meet the conception of elite women during the Joanino Period (1808-1821). Keywords: O castigo da prostituição. Wealthy Woman. Período Joanino.Â
Mães (ex) escravas: análise semá‚ntica do termo mãe em processos de tutela no período pós-abolicionista (1888-1895)
Authors: Santos Jorge Viana , Viana de Carvalho Israela Geraldo
Published: April 2019

Resumo Neste trabalho, investigam-se sentidos do termo mãe funcionando em enunciados de processos de tutela pós-abolicionistas de Rio de Contas-BA mobilizando fundamentos da Semá‚ntica Argumentativa (DUCROT, 1984, 1989, 1998). A análise demonstra que os sentidos do termo no corpus referem-se especificamente á€s mães ex-escravas. Palavras-chave: Mãe Escrava. Semá‚ntica Argumentativa. Sentido. Escravidão.Abstract This work investigates meanings of the word mãe (mother) in child protection procedures from post abolition, of Rio de Contas city (Brazil), based on Argumentative Semantics (DUCROT, 1984, 1989, 1998). The analysis has shown that the meanings of mother in the procedures refer to disqualified experiences of (ex)-slave mothers and singularize them. Keywords: Slave Mother. Argumentative Semantics. Meaning. Slavery.Â
"Eles num vé‚ uma mulhé na água / (...) eles vé‚ como se fosse um homemâ€: cronótopos e performances de gênero na pesca em arraial do cabo
Authors: Ferreira Maria Aparecida
Published: April 2019

Resumo A partir da visão performativa de linguagem e de gênero, este artigo discute como algumas mulheres encenam e legitimam performances de pescadora e problematiza como tais performances atuam na manutenção de performativos de gênero (Butler, 1990; 1993) e de espaços e práticas generificados na pesca (Linsker e Tassara, 2005). Palavras-chave: Gé‚nero. Territorialidades. Performance. Pescadora.Abstract Based on the performative view of language/gender, this article discusses how some women perform and legitimize fisherwoman performances and questions how these performances work in maintaining gender performatives (BUTLER, 1990; 1993) as well as gendered spaces and fishing practices (LINSKER; TASSARA, 2005). Keywords: Gender. Territorialities. Performance. Fisherwomen.Â
A violé‚ncia contra a mulher no Brasil e na Espanha
Authors: Garcia Ana Luíza Casasanta , Goto Tommy Akira
Published: April 2019

ResumoA presente pesquisa do tipo bibliográfica foi realizada utilizando como bases os documentos oficiais do governo espanhol e brasileiro e, mais especificamente das prefeituras municipais de Uberlá‚ndia/BR e Santiago de Compostela/Espanha, a fim de comparar a formulação e aplicabilidade das leis e políticas públicas, considerando os programas existentes. Obteve-se que o sistema de proteção á€ mulher dos dois países é semelhante. Em ambas, há um Centro responsável por acolher denúncias, além de oferecer serviços de atendimento psicológico, jurídico e social. No entanto, há diferenças no que se refere aos programas e auxílio á€s vítimas. Como conclusão, se tem que o combate á€ violé‚ncia contra a mulher é diário e é dependente de uma articulação entre órgãos públicos que, muitas vezes, é falha. Assim, colocar em debate essa questão oferece subsídios para repensar melhores formas e programas e demonstra a relevá‚ncia do tema. Palavras-chave: Violé‚ncia de Gé‚nero. Programas Sociais. Políticas Públicas. AbstractThis bibliographic researchwas performed using as a basis the official documents of the Spanish government and Brazilian and more specifically of the municipalities of Uberlá‚ndia / BR and Santiago de Compostela / Spain, in order to compare the formulation and implementation of laws and public policies considering the existing programs. There was obtained that the system of protection for women in both countries is similar. In both, there is a center responsible for hosting reports, besides offering psychological legal and social services. However, there are differences in relation to programs and aid for victims. In conclusion, there is that the combat of the violence against women is daily and is dependent on the articulation of public agencies that often is failed. So put in debate this issue offers subsidies to rethink the best ways and programs and demonstrates the relevance of the topic. Keywords: Gender Violence. Social Programs. Public Policies.
Movimento social de mulheres e atuação perante o poder judiciário: entre os avanços e as potencialidades ignoradas
Authors: Colombaroli Ana Carolina De Morais
Published: April 2019

Resumo O artigo analisa a atuação do movimento social de mulheres pela via do judiciário, a fim de conquistar e garantir direitos. Busca, por um lado, investigar os avanços alcançados e, por outro, demonstrar as potencialidades de atuação ignoradas pelos feminismos, associando pesquisa bibliográfica, análise de decisões judiciais e pesquisa de jurisprudé‚ncia. Palavras-chave: Movimento Social de Mulheres. Ativismo Jurídico. Direitos da Mulher.Â AbstractThis paper analyses the agency of the women's social movement through the judiciary, in order to conquer and guarantee rights. Aims, on the one hand, investigate the progress achieved and, on the other, demonstrate the ignored agency capabilities by feminisms, combining literature search, analysis of judicial decisions and jurisprudence research. Keywords: Women's Social Movement. Legal Activism. Women's Rights.Â
Espaços, tempos e trocas entre as moças das tranças na "praça nova" da cidade do Lubango, Angola
Authors: Songa Eufrásia Nahako
Published: April 2019

Resumo O interesse pela análise das ações sociais das Moças das Tranças na "Praça Nova" nasce com o intuito de expandir a discussão sobre as (re)significações das tranças e outros penteados em Angola. EÌ evidenciada a presença do gênero feminino e a relação deste na praça e com a praça, instituição fundamental no país que é lugar, não apenas de compra e venda, mas também de socialização e permané‚ncia.Palavras-chave: Moças das Tranças. Praça. Relações Sociais.Abstract The interest in analyzing the social actions of the Braid Women at "Praça Nova" comes on light with the purpose of expending the discussion about the (re)significations of braids and other hairstyles in Angola. It is evidenced the presence of the female gender and its relation in and with the praça, a fundamental institution in the country which is a place, not only for trade, but also for socialization and permanence. Keywords: Braid Women. Praça. Social RelationsÂ
Homens casados que resolvem “sair do armário”
Authors: Machado Rosicléia , Gonçalves Josiane Peres
Published: April 2019

RESUMO: A descoberta da homossexualidade após longo período de relação heteronormativa é o tema do presente estudo que tem por finalidade analisar três casos de homens que se descobriram homossexuais após o casamento, evidenciando como as famílias de diferentes classes socioeconômicas encararam essa mesma realidade.
PALAVRAS-CHAVE: Homossexualidade. Família. Preconceitos.
Entre deusas, ciborgues e o perigo de (querer) ver tudo
Authors: Albuquerque Mariana Imbelloni Braga
Published: April 2019

RESUMO
 O presente artigo propõe um diálogo entre as propostas de conhecimento localizado e a crítica a determinados usos da teoria intersecional não comprometidos com a justiça social. A partir deste diálogo, pensa as implicações do conhecimento localizado nas discussões feministas racializadas.
PALAVRAS- CHAVE:  Conhecimento Localizado. Intersecionalidade. Agenciamento.
Capturing an Evader Using Multiple Pursuers with Sensing Limitations in Convex Environment
Authors: Kumar Amit
Published: April 2019

A modified continuous-time pursuit-evasion game with multiple pursuers and a single evader is studied. The game has been played in an obstacle-free convex environment which consists an exit gate through which the evader may escape. The geometry of the convex is unknown to all players except pursuers know the location of the exit gate and they can communicate with each other. All players have equal maximum velocities and identical sensing range. An evader is navigating inside the environment and seeking the exit gate to win the game. A novel sweep-pursuit-capture strategy for the pursuers to search and capture the evader under some necessary and sufficient conditions is presented. We also show that three pursuers are sufficient to finish the operation successfully. Non-holonomic wheeled mobile robots of the same configurations have been used as the pursuers and the evader. Simulation studies demonstrate the performance of the proposed strategy in terms of interception time and the distance traveled by the players.
Design and Validation of Blast Non-propagation Wall for Multi-Compartmented Explosive Storage Structure of Capacity 5T NEC per Compartment
Authors: Thakur Prabhanjan Kumar , Mishra Rajesh , Tanwar Rajesh Kumar , Mishra Ghanshyam Kumar , Narang Rajiv
Published: April 2019

Conventional magazines for hazard division 1.1 are constructed using bricks and reinforced cement concrete (RCC) for which storage inside quantity distance (SIQD) is 2.4 W1/3 m, where W is Net Explosive Content in kg. New composite called laced reinforced concrete (LRC) has been developed recently, for which SIQD has been reduced up to 0.5 W1/3 m. Due to substantial reduction in separation distances, the requirement of land area has been reduced significantly. Although SIQD has been reduced drastically due to development of new composite, the other quantity distances like process inside quantity distance (PIQD) and outside quantity distance (OQD) decreased marginally. To reduce these quantity distances, the solution is multi-compartmented structures based on Unit Risk Principle. The application of unit risk principle enables the separation of explosives into compartments in such a manner that initiation of explosives in one compartment does not result in initiation of the explosives in adjacent compartments. This is achieved by special design of explosive storage buildings incorporating blast non-propagation walls between adjacent compartments storing explosives. Quantity distances are reduced for such magazines, as maximum credible limit corresponds to the quantity of explosive in one compartment. Present paper describes design and full scale testing of blast non-propagation wall between two compartments of a multi-compartmented explosive storage structure with storage capacity of 5 T Net Explosive Content (NEC) of HD 1.1 per compartment. The blast non-propagation wall comprising of sand filling and air gap between LRC walls has been designed for desired attenuation of blast parameters as well as for arresting high velocity fragments/debris. The design has been validated by fully instrumented design validation field trial. The conduct of the trial as well as the results are discussed in this paper.
Characterization of High Porous PZT Piezoelectric Ceramics by different Techniques
Authors: B Praveen Kumar , Rawal Bhupender , Rajan KM
Published: April 2019

Ultimate properties of a porous ceramic is highly process dependent. In this study, prevalent porous ceramics fabrication methods (Freeze casting, Foam reticulation and Burnable Plastic Sphere (BURPS) method) have been compared by fabricating the porous lead zirconate titanate (PZT) based piezoelectric ceramics. Field Emission Scanning electron microscopy (FESEM) studies were carried out to study the pore size and distribution of the ceramics. Hydrostatic co-efficients increased tremendously on incorporation of porosity which led to Hydrostatic Figure of Merit of 7480 in Foam reticulation samples (porosity 86%). The three dimensionally interconnected networks in the freeze casted samples led to lowest acoustic impedance (6 MRayls) despite not having the lowest density.
Small-Caliber Grenade Projectile Applicable to Individual Grenade Launchers
Authors: Taraszewski Michal , Ewertowski Janusz
Published: April 2019

An overview of development of grenade types for individual grenade launcher is presented. Considering historical and current research programs, a new type of projectile is proposed. Results of initial experiment which verifies chosen approach are included herein. It is said, based on obtained results, that showed new design can be applied in different applications without negative impact on combat capabilities – it even increases some crucial criteria. Current study indicates nearly 30 per cent increase of the effective exit velocity, however there is a design space where further investigation and optimisation can provide additional profits.
Removal of iron oxides from a sixteenth century ornamental fountain belonging to Quinta da Cardiga (Torres Novas, Portugal)
Authors: Pereira Nuno , Rocha Marco , Rosa Manuel , Costa Fernando
Published: April 2019

The ornamental fountain in marble and breccia is a 16th century Italian work integrated in the small courtyard of the Cardiga Palace (Torres Novas, Portugal) currently in restauration process. The iron spikes used to connect the constituent elements were corroded and contaminating the base stone elements surfaces with intense stains of metallic oxides. There was a suspicion that, apart the surface, these oxides could have migrated in depth through the porous structure of the material. The performance of the iron oxides removal tests was evaluated using optical measurements in the CIELAB color space after each chelant application. Sodium dithionite was found to exert a substantially higher cleaning action than ammonium citrate. After finishing the treatment with the most efficient chelant, the chelating action was verified below the surface of the marble. It was found that at the depth of 1 mm the material remained contaminated with iron oxides, with an evident color contrast with a treated surface.
Terminologiedatenaustausch mit TERMDAT – Passgenaue Schnittstellen für die Terminologiedatenbank der Schweizerischen Bundeskanzlei
Authors: Reineke Detlef
Published: April 2019

The terminology database TERMDAT is at the very heart of the Terminology Section of the Swiss Federal Chancellery’s Central Language Services. It provides Swiss legal and administrative terminology predominantly for the four national languages German, French, Italian, and Romansh (plus English). However, data exchange with cooperating actors (Federal Departments, cantons, external service providers, etc.) constitutes a particular challenge, since these actors operate with different systems and data models. The present article describes a solution developed within a pilot project aiming at providing means to substantially improve data flow within a highly heterogeneous database landscape.
The Figure of the Day: A Classroom Activity to Improve Students' Figure Creation Skills in Biology
Authors: Kirby Caitlin K. , Fleming-Davies Arietta , White Peter J. T.
Published: April 2019

Creating and interpreting visual displays of data is an important component of quantitative and scientific literacy. We examined a figure-analysis activity called “Figure of the Day” (FotD) and its impact on undergraduate biology students' figure creation skills. The treatment FotD activity required that students interpret a figure with some contextual information missing (e.g., titles, labels, legends). The control FotD activity required that students interpret a figure with no missing contextual information. Students in both the treatment and control groups made significant gains in their figure creation abilities. Bootstrapping of the Wilcoxon signed-rank effect sizes, r, shows large effect sizes for both the treatment (r ± SE = 0.708 ± 0.034) and control (r ± SE = 0.688 ± 0.0395) activities. Students most often reported that the activity's positive aspects were increases in their figure interpretation and creation skills. Commonly reported negative aspects of the activity were that it took too much time and the figures were confusing. Students in the treatment group more often reported that the activity was enjoyable. This suggests that regular interaction with figures in the style of the FotD activity can improve students' figure creation skills in a meaningful and enjoyable way.
Glucocorticoids and programming of the microenvironment in heart
Authors: Song Rui , Hu Xiang-Qun , Zhang Lubo
Published: April 2019

Glucocorticoids are primary stress hormones and can improve neonatal survival when given to pregnant women threatened by preterm birth or to preterm infants. It has become increasingly apparent that glucocorticoids, primarily by interacting with glucocorticoid receptors, play a critical role in late gestational cardiac maturation. Altered glucocorticoid actions contribute to the development and progression of heart disease. The knowledge gained from studies in the mature heart or cardiac damage is insufficient but a necessary starting point for understanding cardiac programming including programming of the cardiac microenvironment by glucocorticoids in the fetal heart. This review aims to highlight the potential roles of glucocorticoids in programming of the cardiac microenvironment, especially the supporting cells including endothelial cells, immune cells and fibroblasts. The molecular mechanisms by which glucocorticoids regulate the various cellular and extracellular components and the clinical relevance of glucocorticoid functions in the heart are also discussed.
The Immigrant Parent Disadvantage: Parent Linguistic Capital and Student School Performance
Authors: Fontana Jason J.
Published: April 2019

Researchers, teachers and policy makers continue to wrestle with understanding why children of immigrants perform more poorly in school than their counterparts with native born parents.  While parental involvement through checking of homework and participation in school events have been identified as relevant factors, the findings of research are not conclusive.  This study re-examines the relationships of these two factors with school performance among the children of Spanish-speaking immigrants by introducing a third variable: parental English proficiency.  The results reveal that after controlling for parental English proficiency, homework checking no longer has a significant impact and the effect of parental school involvement is reduced; English language abilities of parents, on the other hand, have a significant effect on student performance. This finding suggests that improving parental English proficiency and cultural awareness can produce a positive impact on the school performance of the children of non-native English speaking parents.
A Horse Derby, A Missed Connection, and Hiking through the Alps: John Dewey's 1928 visit to the Soviet Union
Authors: Ryabyy Vladislav
Published: April 2019

After December 6, 1917, the government of the United States led by President Woodrow Wilson decided not to recognize the new government of Russia, which was led by the Bolshevik Party. Some of the reasons for this lack of recognition came from the Bolshevik government’srefusal to honor prior debits owed by the Tsarist government and the seizure of American property. The next three presidents would continue this policy.1 For the next sixteen years, many Americans visited and wrote about the Soviet Union. Amongst those visitors was a delegation of twenty-five who visited the Soviet Union in the summer of 1928. Their stated purpose was to,“study methods of public instruction in Soviet Russia this summer.” 2 The most influential amongst the twenty-five was John Dewey, a professor of philosophy at Colombia University and one of the leading educational reformers in the United States. In the time during and after this trip Dewey wrote a series of articles for the “New Republic” and later collected these articles andplaced them in his book, Impressions of the Revolutionary World.3 This book also dealt with his travels to China in 1920, Turkey in 1924, and Mexico in 1926. This book does not tell the full story of the trip. By analyzing his letters that he sent during this time, one can recreate a partial itinerary of his daily activities and those that he met with. Those letters also reveal that this trip influenced not only the twenty-five educators from the United States but also had an impact on Soviet educators because they had the ability to finally meet the man that they had studied for so long. The United States Department of State was also interested in this trip and used it to learn more about the Soviet Union. The Department of State was also dealing with anticommunism at this time and this caused Dewey’s trip to be closely monitored. The New York Times and other newspapers reported on this trip and the aftermath of this trip can be seen through these reports. This trip impacted not only those within the Soviet Union but also the State Departments and the American public’s view of the Soviet Union.
Significance of Bottle Gourd sign on computed tomography in patients with abdominal cocoon: a case series
Authors: Sharma Vishal , Mandavdhare Harshal S , Singh Harjeet , Gorsi Ujjwal
Published: April 2019

Abdominal cocoon is an uncommon entity manifesting as abdominal pain, lump and features of intestinal obstruction. The diagnosis is established by demonstrating a membranous sac covering the small bowel loops which can be seen at the time of surgery or demonstrated by imaging studies like computed tomography (CT) or magnetic resonance imaging. CT has been reported to be of utility in making a preoperative diagnosis. The features may include clumped bowel loops, loculated fluid, cauliflower sign or concertina arrangement of bowel loops. We report on three cases of abdominal cocoon who presented with intestinal obstruction due to three varied etiologies (idiopathic, tuberculosis, malignancy). We also describe a radiological sign, the bottle gourd sign, in these three cases. The sign possibly suggests jejunal obstruction due to formation of abdominal cocoon.
Laminate veneers: mimetizing nature through anatomical remodeling – case report
Authors: Higashi Dayla Thyeme , Hoeppner Márcio Grama , Terada Raquel Sano Suga , Iris Mariana Paizana , Cogo Renato Batista
Published: April 2019

OBJECTIVE: Dental aesthetics is one of the areas of dentistry that has most advanced in terms of procedures, techniques and materials. Changes in color, shape, and texture are commonly cited as grounds for complaint, which are sometimes characterized by details, making the work challenging. The objective of this work is to report the planning and execution of a clinical case of smile harmonization with ceramic laminates for remodeling smile.CASE DESCRITION: A male patient consulted a specialist to refine the appearance of his smile that already had a satisfactory pattern of color and texture. The planning was started using digital smile planning, followed by diagnostic waxing of the elements involved. The planning approval took place through the Mock up. The dental grinding performed was minimal and followed a silicone wear guide. The pieces were made in lithium disilicate and installed under absolute isolation according to the cementing protocol of the material. The finishing and polishing completed the installation of the pieces, removing excesses and guaranteeing periodontal compatibility.CONCLUSION: We conclude that indirect aesthetic treatments currently have a minimally invasive character and are highly accepted due to their ability to remodel the smile with perfection and naturalness.
Enamel microabrasion: achieving aesthetic success to dental fluorosis in a single session – one-year follow-up
Authors: Costa Cecília Atem Gonçalves de Araújo , Silveira Rodrigo Richard da , Pereira José Carlos , Mendonça Juliano Sartori , Santiago Sérgio Lima
Published: April 2019

OBJECTIVE: To describe the enamel microabrasion technique used to treat the patient with white stains due dental fluorosis, highlighting the importance of complete anamnesis and clinical examination to achieve the clinical success.CASE DESCRIPTION: patient’s complains, aesthetic self-perception, age, general health, history of excessive intake of fluoride and time of teeth development were considered to the diagnosis and treatment plan. Also, dental trans illumination was used to evaluate the white spots diffusion and estimate the lesion’s length. An abrasive paste mixture of equal parts 37% phosphoric acid and pumice was applied with a wooden spatula in order to perform enamel microabrasion. After the last application, the teeth were polished with finishing discs and a neutral sodium fluoride gel was applied to enamel remineralization. Satisfactory results in the aesthetic improvement were possible with a minimally invasive and cost-effective technique. The dental trans illumination after treatment showed the disappearance of the enamel opacities, preserved on the one-year follow-up.CONCLUSION: Cosmetic dentistry has been increasingly practiced today. However, a correct aesthetic planning should be based on current restorative dentistry concept. For any type of procedure, the dentist should opt for sound tooth structure preservation. This technique might be an efficient alternative to restorative treatments and can be considered a successful procedure. In cases of esthetic alterations due fluorosis, non-invasive methods such enamel microabrasion should be considered before invasive restorative treatments.
Survival and factors associated with mandibular overdenture fractures with immediate loading
Authors: Silva Cleice Luizi da , Farias Danielle Bezerra de , Campos Maria De Fátima Trindade Pinto , Melo Laércio Almeida de , Ferreira Maria Angela Fernandes , Carreiro Adriana Da Fonte Porto
Published: April 2019

OBJECTIVE: Survival rates of mandibular overdentures on two implants retained by bar-clip system with immediate loading and the factors related to fractures was analyzed.METHODS: Twenty-three subjects were followed for 32 months. Fracture occurrence was the outcome variable, while the thickness of denture base, maxillomandibular space and masticatory efficiency comprised the independent variables.RESULTS: The survival rate was 49.5%, with 34.7% of fractures. There was no association between the independent variables and fractures.CONCLUSION: So, the risk of mandibular overdenture fractures with immediate loading is high. Furthermore, masticatory efficiency, thickness of the denture base and maxillomandibular space did not influence the incidence of fractures.
Degree of MDM2 Amplification Affects Clinical Outcomes in Dedifferentiated Liposarcoma
Authors: Bill Kate Lynn J. , Seligson Nathan D. , Hays John L. , Awasthi Achal , Demoret Bryce , Stets Colin W. , Duggan Megan C. , Bupathi Manojkumar , Brock Guy N. , Millis Sherri Z. , Shakya Reena , Timmers Cynthia D. , Wakely Paul E. , Pollock Raphael E. , Chen James L.
Published: April 2019

Background

Dedifferentiated liposarcomas (DDLPS) are mesenchymal tumors associated with universally poor response to treatment. Genomic amplification of murine double minute 2 (MDM2) is used as a diagnostic biomarker; however, no established biomarkers exist to guide DDLPS treatment. In the largest study of its kind, we report that the extent of MDM2 amplification, not simply the presence of MDM2 amplification, may be biologically important to the actions of DDLPS.

Patients and Methods

The distribution of MDM2 amplification in DDLPS was assessed using data from a commercial sequencing laboratory (n = 642) and The Cancer Genome Atlas (n = 57). Data from two retrospective clinical trials (n = 15, n = 16) and one prospective clinical trial (n = 25) were used to test MDM2’s utility as a clinical biomarker. in vitro and in vivo assessments were conducted in DDLPS cell lines.

Results

Genomic MDM2 amplification follows a highly reproducible log-normal distribution. In patients with DDLPS treated with complete tumor resection, elevated MDM2 was associated with shortened time to recurrence as measured by genomic amplification (p = .003) and mRNA expression (p = .04). In patients requiring systemic therapy, higher MDM2 amplification was associated with reduced overall survival (p = .04). Doxorubicin treatment of DDLPS cells in vitro demonstrated variable sensitivity based on baseline MDM2 levels, and doxorubicin treatment elevated MDM2 expression. In vivo, treatment with doxorubicin followed by an MDM2 inhibitor improved doxorubicin sensitivity.

Conclusion

MDM2 amplification levels in DDLPS follow a reproducible distribution and are associated with clinical outcomes and drug sensitivity. These results suggest that a prospective study of MDM2 as a predictive biomarker in DDLPS is warranted.
Avaliação da profilaxia antimicrobiana cirúrgica em um hospital de ensino
Authors: Melo Matheus Santos , Carvalho Thialla Andrade , Mattos Maria Cláudia Tavares , Campos Maria Pontes Aguiar , Mendonça Simonize Barreto , Lobo Iza Maria Fraga
Published: April 2019

Justificativa e Objetivos: Diante da relevância e escassez de estudos realizados na região nordeste do Brasil, este estudo tem o objetivo de avaliar a profilaxia antimicrobiana no perioperatório de cirurgias eletivas realizadas em um hospital de ensino de Sergipe. Método: Estudo descritivo a partir da coleta de dados contidas em formulários de vigilância de eventos adversos da instituição, no período de janeiro a dezembro de 2015. As variáveis analisadas foram relacionadas à caracterização dos pacientes, procedimentos cirúrgicos realizados e profilaxia antimicrobiana cirúrgica. Para as variáveis categóricas foi realizada análise por distribuição de frequência e para as variáveis quantitativas, as medidas de tendência central e de dispersão correspondentes no software Epi-Info 7, após atender os preceitos éticos. Resultados: Foram avaliadas 752 fichas de vigilância de eventos adversos e complicações pós-operatórias. A profilaxia antimicrobiana foi utilizada em 78,80% das cirurgias, seguiu à padronização do serviço de controle de infecção quanto a seleção do antibiótico (91,80%), administrada no momento ideal (10,90%) e considerada adequada (escolha do antibiótico, momento da administração e duração da profilaxia) (4,40%). A classe de antibiótico de maior escolha foi a das cefalosporinas (93,60%) e o repique foi realizado em somente 22,20% das cirurgias que tinham indicação. Conclusão: A maior parte do uso da profilaxia antimicrobiana não cumpre as diretrizes recomendadas pelos guidelines nacionais e internacionais. Achado que reforça a necessidade de realizar intervenções que levem a mudanças no processo de trabalho das equipes cirúrgicas e garantam a qualidade da assistência e segurança do paciente. Descritores: Infecção da Ferida Cirúrgica; Antibioticoprofilaxia; Segurança do Paciente.
Culturing Euplotes crassus to high densities using a combination of algae and bacteria as the food source. v1
Authors: A. Klobutcher Lawrence , Klobutcher Larry
Published: April 2019

This procedure was developed to investigate the possible use of RNAi through bacterial feeding as a means of knocking down expression of particular genes. While the utility of RNAi is still being investigated, the method is effective in growing Euplotes crassus to higher densities than is possible using algae alone. Using moderately dense cultures of algae, we typically achieve cell densities of 500-1,000 cells/ml, while with the E. coli supplemented cultures we describe here, Euplotes cell densities exceed 3,000 cells/ml. In fact, preliminary studies mixing a volume of a Euplotes culture with an equal volume of resuspended E. coli have produced a density of ~8,000 cells/ml. While the described procedure involves small cultures, it can likely be scaled up as required. For some species of Euplotes, long-term culture using bacteria as a food source has not been successful (C. Miceli, personal communication), suggesting that some essential nutrient is not being provided in sufficient quantitities
A Randomized Trial of a Pilot Behavioral Support Intervention After Bariatric Surgery v1
Authors: Lent Michelle
Published: April 2019

Bariatric surgery patients may experience significant psychosocial changes after surgery, but little psychological support is available beyond support groups postoperatively. We evaluated the feasibility of a postoperative support program targeting quality of life, psychosocial functioning and adherence to behavior change in bariatric surgery patients. This prospective, randomized pilot trial evaluated a comprehensive postoperative behavioral support intervention using a 4-month bi-weekly program in 24 bariatric surgery patients compared to 26 usual care patients that completed bariatric surgery within one year. Outcomes included feasibiilty and the difference in quality of life (as measured by the Short Form-36) between groups, as well as differences in psychosocial functioning (mood, eating behaviors) and adherence (diet, physical activity, appointments). Outcomes were assessed at baseline and treatment completion (4 months). The intervention focused on addressing psychosocial changes after surgery, strategies for postoperative diet and adherence, and preventing weight regain. Patients collaboratively set goals for diet, physical activity, adherence and other behavioral changes tailored to the needs of each participant. Intervention patients were asked to attend 8, one-hour bi-weekly treatment sessions in a 4-month time period.
Agentenbasiertes Energiemanagement
Authors: Schmitz Norbert
Published: April 2019

Im Rahmen der Energiewende hin zur erneuerbaren Energie wird der Beitrag privater Haushalte immer wichtiger. Frühere reine Verbraucher werden zu Energielieferanten mit einem erheblichen Einfluss auf die Energieflüsse. Intelligente Energiemanager helfen sowohl die Energieflüsse innerhalb als auch außerhalb des Hauses zu optimieren. Für diese Optimierung sind intelligente Strategien notwendig. Im Rahmen der vorliegenden Arbeit wird ein agentenbasiertes Verfahren zur Energieoptimierung vorgestellt, dass durch seine modulare Architektur eine hohe Flexibilität und Skalierbarkeit hat. Anhand realer Energiedaten wird dabei die Effizienz des Ansatzes gezeigt.
Integrating Digital Libraries into Distance Education: A Review of Models, Roles, And Strategies
Authors: OWUSU-ANSAH Christopher M. , RODRIGUES Antonio Da Silva , WALT Thomas B. Van Der
Published: April 2019

This study examines ongoing efforts by academic libraries to integrate digital resources into distance education courses. The study adopts a conceptual approach and it is thematically focused on the concepts of distance education and digital libraries; academic library models in distance education; the role of digital libraries in distance education; and strategies for integrating digital libraries into distance education. Through a systematic literature review and thematic analysis of extant literature, the paper concludes that academic libraries must pragmatically integrate digital libraries into the distance education curriculum by highlighting the role of digital libraries in the academic community and her processes. In this way, digital libraries may not be perceived as just content providers, but as significant agents of transformative learning.
The Role of the Triad of Traits “Tolerance for Uncertainty – Emotional Intelligence – Intuition” in Self-Assessed Creativity in Creative Professionals
Authors: Pavlova E.M. , Kornilova T.V.
Published: April 2019

The article presents an overview of the relationships between creativity and personality traits, namely, tolerance/intolerance for uncertainty, emotional intelligence, intuition, and self-assessed creativity. We report on the results of an empirical study that highlighted the importance of this Positive Triad of traits in creativity measured via the ‘Creative Cartoons’ task. Three groups of accomplished creative professional participated in the study (writers, composers, and directors), for a total n = 52. In addition to administering the Creative Cartoons task, we administered a set of assessments: self-assessed creativity (using the procedure parallel to that proposed by A. Furnham for studying self-assessed intelligence), T. Kornilova’s New questionnaire for tolerance to uncertainty (NTN), the Emotional Intelligence (EmIn) questionnaire developed by D. Lyusin, and S. Epstein’s Rational-Experiential Inventory. A correlational analyses of the relationships between the studied traits provided support for the hypotheses related to the positive role of the Positive Triad of traits in creativity. Psychometric creativity was related to self-assessed creativity and trust in intuition, whereas intuition was related to tolerance for uncertainty, in its turn related to interpersonal emotional intelligence. Intrapersonal emotional intelligence, on the other hand, was negatively correlated with interpersonal intolerance for uncertainty: thus, both emotional intelligence traits were associated with a more positive attitude towards uncertainty.