bluuebunny/crossref_metadata_2025 huggingface dataset:
Analysis of throughput of pipe crossings on lower categories of roads
Authors: Виноградов А.Ю. , Ржавцев А.А. , Зубова О.В. , Обязов В.А. , Фурсов К.А. , Хвалев С.В. , Кадацкая М.М. , Парфенова М.А. , Виноградов И.А.
Published: November 2020

Рассмотрен анализ работы водопропускных сооружений на региональных дорогах Ленинградской области. Обозначены основные проблемы, связанные с неудовлетворительной работой трубных переходов, приведены примеры последствий с оценкой ущерба. Проведены полевые обследования трубных переходов во Всеволожском районе Ленинградской области. Выявлено, что около 50% водопропускных сооружений не пригодны к эксплуатации, соответственно могут стать причиной затопления территорий, остальные ограниченно пригодны. Даны рекомендации по содержанию и реконструкции трубных переходов для предотвращения чрезвычайных ситуаций.

The article analyzes the operation of culverts on regional roads in the Leningrad region. The main problems associated with unsatisfactory operation of pipe crossings are identified, and examples of consequences with damage assessment are given. In this work, field surveys of pipe crossings in the Vsevolozhsky district of the Leningrad region were conducted. As a result, it was found that about 50% of culverts are not suitable for operation, respectively, they can cause flooding of territories, while the rest are of limited use. Recommendations are given on the maintenance and reconstruction of pipe crossings to prevent emergencies.
Extraction of valuable components from fruits of the hawthorn and barbaris of the North-West region
Authors: Морозкова И.А. , Кутакова Н.А. , Третьяков С.И. , Васильева Н.Н.
Published: November 2020

Плоды барбариса и боярышника содержат ценные биологически активные вещества: органические кислоты, сахара, дубильные вещества, антоцианы, аскорбиновую кислоту и другие компоненты. Количественное содержание этих групп соединений в данном материале зависит от эколого-географических, климатических факторов, условий выращивания, способа сушки и др. Сопоставление состава плодов, собранных в Дендросаду САФУ (г. Архангельск) в 2015–2018 гг., и основных климатических характеристик вегетационного периода показало, что влияние климата велико. Результаты исследования состава плодов нескольких видов барбариса и боярышника характеризуют их как ценный материал для более глубокого изучения и переработки. Как показывают имеющиеся данные, анализируемые вещества проявляют разнообразный спектр фармакологической активности: противовирусные, противовоспалительные, антимикробные, антидиабетические и противоопухолевые свойства. Для извлечения комплекса БАВ предложено использовать 70%-й этиловый спирт. Проведена оценка эффективности извлечения БАВ различными методами: метод настаивания, ультразвуковой обработки и экстракции в электромагнитном поле сверхвысоких частот (СВЧ), из них СВЧ-экстракция признана перспективной. Степень извлечения компонентов составила в среднем 50%. Плоды являются перспективными для использования в пищевой промышленности и для разработки новых лечебно-профилактических лекарственных средств на основе экстрактов.

The fruits of barberry and hawthorn contain valuable biologically active substances: organic acids, sugars, tannins, anthocyanins, ascorbic acid and other components. The quantitative content of these groups of compounds in this raw material varies depending on ecological, geographical, climatic factors, the phase of plant growth, cultivation technology, drying method, etc. Comparison of the composition of the fruits collected in the Dendrosade of NArFU (Arkhangelsk) in 2015–2018 with the main climatic characteristics of the growing season showed that the influence of the climate is great. The results of a study the composition of the fruits of several types o of barberry and hawthorn characterize them as valuable material for a promising source for deeper study and processing. As the available data show, the analytes exhibit a diverse spectrum of pharmacological activity: antiviral, anti-inflammatory, antimicrobial, antidiabetic and antitumor properties . To extract the complex of biologically active substances, it is proposed to use 70% ethanol. The efficiency of extraction of biologically active substances by various methods was evaluated: the method of insisting, ultrasonic treatment and extraction in an electromagnetic field of microwave frequencies, of which microwave extraction was recognized as promising. The degree of extraction of the components averaged 50%. The fruits are promising for use in the food industry and for the development of new therapeutic and preventive medicines based on extracts.
Rauner - one and a half centuries in the service of forestry in Russia
Authors: Липин В.А.
Published: November 2020

В статье впервые в обобщенном виде приводятся ранее неопубликованные сведения о судьбе и деятельности представителей династии выходцев из Австрии Раунеров на русской службе и в послереволюционный период. На основе архивных материалов, редких и малодоступных публикаций, а также материалов из частных собраний отражены малоизвестные страницы истории лесного хозяйства России. Непосредственно к лесному делу России имели отношение целый ряд представителей клана Раунеров. Юлий Карлович Раунер, который учился в Лисинском учебном лесничестве. С 1855 г. Ю.К. Раунер главный лесничий Екатеринбургского горного округа. Наибольшей известности в лесоводстве достиг Станислав Юльевич Раунер, лесовод, мелиоратор, теоретик и практик горно-облесительных работ, проводимых в целях борьбы с эрозией почв и селевыми потоками. После окончания Алексеевского Екатеринбургского Реального училища с 1879 по 1882 год С.Ю Раунер являлся студентом Лесного института в Петербурге. Влияние леса на режим поверхностных и подземных вод составляло предмет особенно тщательного изучения С.Ю. Раунера. С середины 80-х годов XIX в. до 1917 года С.Ю. Раунером было написано большинство научных трудов, составлено множество инструкций и программ, непосредственно по географическому, биологическому и другим исследованиям. После Революции с 1917 г. С.Ю. Раунер работал в Москве в ВСНХ в должности Заместителя председателя Госплана. В 1920 году был выбран профессором лесного института в Петрограде.

For the first time, the article summarizes previously unpublished information about the fate and activities of representatives of the dynasty of come from Austria, Rauner in Russian work for the government and in the post-revolutionary period. On the basis of archival materials, rare and inaccessible publications, as well as materials from private collections, little-known pages of the history of forestry in Russia are described. A number of representatives of Rauner clan were directly involved in forestry in Russia. Julius Karlovich Rauner, who studied at the Lisinsky training forestry. Since 1855, Yu.K. Rauner is the chief forester in the Yekaterinburg mountain district. Stanislav Yulievich Rauner, a forest grower, land reclamator, theoretician and practitioner of mining and afforestation works carried out to combat soil erosion and mudflows, became the most famous in forestry. After graduating from the Alekseevsky Yekaterinburg Real School from 1879 to 1882, S.U. Rauner was a student at the Forest Institute in St. Petersburg. The influence of the forest on the regime of surface and groundwaters was the subject of a particularly thorough study by S.Yu. Rauner. Since the mid 80s of the XIX century. until 1917 S.Yu. The majority of scientific works were the rauner, many instructions and programs were compiled, directly on geographical, biological and other studies. After the Revolution since 1917, S.Yu. Rauner worked in Moscow at the Supreme Economic Council as a Deputy Chairman of the State Planning Commission. In 1920 he was chosen as a professor at the Forestry Institute in Petrograd.
Foliage Biomass of the forests of Eurasia: correction of empirical modeling methods
Authors: Усольцев В.А. , Ковязин В.Ф. , Цепордей И.С. , Часовских В.П. , Азаренок В.А.
Published: November 2020

При разработке аллометрических моделей биомассы деревьев и древостоев имеется ряд неопределенностей, обусловленных несовершенством методических приемов как при получении исходной информации, так и при ее обработке с целью выявления искомых закономерностей. В статье дан анализ двух методических мифов, распространенных при оценке биомассы ассимиляционного аппарата деревьев и древостоев. Использована база экспериментальных данных о биомассе хвои (листвы) деревьев и древостоев соответственно в количестве 10,9 и 2,94 тысяч определений 16 и 10 древесных видов (родов) Евразии. На их основе построены всеобщие модели (generic models) биомассы хвои (листвы) на уровнях дерева и древостоя. Показано завышение оценок биомассы листвы (хвои) в результате механического переноса традиционного метода моделирования объема ствола дерева и древостоя на оценку биомассы их ассимиляционного аппарата. Рекомендовано отказаться от использования предиктора (D2 H) и включать в модель или один диаметр ствола, или диаметр ствола и высоту дерева раздельно. От использования полноты в качестве независимой переменной в модели ассимиляционного аппарата древостоев можно отказаться и во избежание возможных смещений оценок включать вместо полноты совокупность двух независимых переменных – густоту древостоя и средний диаметр стволов.

When developing allometric models of the biomass of trees and forests, there are a number of uncertainties due to the imperfection of methodological techniques both for obtaining harvest data and for processing it in order to identify the desired patterns. Two methodological myths are analyzed in the paper that are common in assessing the foliage biomass of trees and stands. We used the database of harvest data on the foliage biomass of trees and stands, in the amount of 10.9 and 2.94 thousand definitions of 16 and 10 tree species (genera) of Eurasia respectively. Generic models of the foliage biomass are designed at tree and stand levels. It is shown that the estimation of foliage biomass is overestimated as a result of mechanical transfer of the traditional methods of modeling the volume of a tree stem and a forest stand to the estimation of the foliage biomass. It is recommended to abandon the use of the predictor (D2 H) and include in the model either single diameter of a stem, or the stem diameter and tree height separately. The use of basal area as an independent variable in the model of the stand foliage can be abandoned and, in order to avoid possible biases of estimates, include instead of it a set of two independent variables – the tree density and the average stem diameter.
A Study on Cotton (Gossypium sp.) Nectar Production in Uzbekistan
Authors: HAMIDOV G’ulom , MAXSUDOV Qodirjon , VOXOBOVA Shahzoda , AKRAMOVA Dilyora
Published: November 2020

Given the importance of cotton varieties in beekeeping, we have been able to determine the nectar and honey yield per hectare for several years Cotton nectaries produce highly concentrated carbohydrates, nectarines, amino acids and fatty acids. Unlike other types of plants. In different varieties of cotton, there are 4 types of nectaries (intra-cup, bract, sub-bract, and leaf), and the number and concentration of nectarium are different for all types. Nectar productivity of fine fiber varieties is significantly higher than that of medium fiber varieties. Nectar is an important nutrient source for insects and pathogens due to its high sugar content. Several methods of nectar determination were used to determine the number of angles of cotton varieties planted in the country, such as "tube" and "washing." On average, honey yield of these varieties is 50-60 kg per hectare. It is understood from the research results that cotton varieties have high honey and nectar productivity in Uzbekistan environment.
Complementarism and Consolationism
Authors: Agada Ada
Published: November 2020

Afrička je filozofija bila primorana stalno se određivati u odnosu prema
dominantnoj zapadnoj filozofiji, što je bilo uvjetovano povijesnim okolnostima kolonijalizma i dvostrukog nasljeđa profesionalnog afričkog filozofa, afričkog po kulturnoj povezanosti, ali sudionika u zapadnoj civilizaciji temeljem njihove zapadnjačke izobrazbe. Mnogi su poznati afrički filozofi odgovorili na izazov nametnut iznimnim uspjehom zapadne
filozofije time što su, s jedne strane, filozofirali na načine koji teže nadilaziti čistu afrocentričku agendu, a s druge strane, nekritički
prihvatili zapadnofilozofijske metode. U ovom radu predstavljam te istražujem odgovore poznatog nigerijskog filozofa Innocenta Asouzua na krizu identiteta u afričkoj filozofiji. Demonstriram da je Asouzuova filozofija ibuanyidandijskog komplementarizma filozofijska sinteza koja teži nadilaženju famoznog prijepora između univerzalizma i partikularizma nalazivog u afričkog filozofiji. Primjenjujući ekspozitornu, analitičku i vrednujuću metodologiju, pokazujem kako filozofijska struja konzolacionizma unapređuje filozofijsku putanju kojom se Asouzu kretao. U afričku filozofiju uvodim opću kategoriju utjehe koja podaruje panpsihistički okvir za istraživanje smisla u tragičnom svemiru.
Potential health risk assessment related to arsenic pollution and hydrogeochemistry of groundwaters in Akşehir and surroundings (Konya/Turkey)
Authors: Varol Simge
Published: November 2020

Groundwater is an important water resource used for drinking, domestic and agricultural activities in Akşehir and surroundings. However, intensive agricultural and human activities in the region adversely affect groundwater quality. In this study, 31 water samples were collected from wells. According to the Piper diagram, groundwater in the study area was in the Ca–Mg–HCO3 and Ca–HCO3 water facies. As a result, it is not appropriate to use groundwater as drinking water in the study area in terms of trace elements and pollutant analysis results of water samples compared to limit values determined by WHO and ITHASY drinking water guidelines. The arsenic concentration in groundwater was studied in detail. The origin and concentration of arsenic in groundwater is associated with agricultural activities and pesticides in the region. Accordingly, a health risk assessment was carried out for the use of groundwater in the study area as drinking water. The results for all samples analyzed indicate that the groundwater concerned was not suitable for drinking purposes because of arsenic concentrations which exceeded maximum acceptable levels.
Economía aplicada: ensayos de investigación económica 2017
Authors: González Vigil Fernando , Obando Hirano Pilar
Published: November 2020

El presente volumen de la serie Ensayos de Economía Aplicada contiene nueve ensayos, los cuales son versiones resumidas y editadas de cinco TIE culminados en junio de 2017 y cuatro culminados en noviembre del mismo año. Además de reunir los dos requisitos antes mencionados, a sus respectivos autores les fue posible resumirlos y presentarlos en una versión ensayo dentro de los límites de extensión y plazos de entrega fijados para la preparación de este volumen.
Alkaloids of Peganum harmala: Anticancer Biomarkers with Promising Outcomes
Authors: Jalali Atefeh , Dabaghian Farid , Zarshenas Mohammad M.
Published: November 2020

Background:

Cancer is a serious and growing global health issue worldwide. In the cancerous cells, the normal cell cycle has been disrupted via a series of irreversible changes. Recently, the investigations on herbal medicine and clarifying the phytochemicals potential in treat cancer has been increased. The combination of phytochemicals with conventional cancer treatment approaches can improve outcomes via advancing cell death, restraining cell proliferation and invasion, sensitizing cancerous cells, and promoting the immune system. Therefore, phytochemicals can be introduced as relevant complementary medicaments in cancer therapy. Peganum harmala L. (Zygophyllaceae) as a valuable medicinal herb, possesses various alkaloid ingredient.

Objective:

Pointing to the importance of new avenues for cancer management and P. harmala convincing effect in this field, this review strived to collect a frame to epitome possible scopes to develop novel medicines in cancer treatment.

Methods:

Keywords "Peganum harmala" and cancer, or chemotherapy, or anti-neoplasm were searched through the "Scopus" database up to 29th of February 2020. Papers linking to agriculture, chemistry, environmental, and genetics sciences were omitted and, papers centered on cancer were selected.

Result and Discussion:

In the current study, 42 related papers to cancer treatment and 22 papers on alkaloid bioactive components are collected from 72 papers. The β-carboline alkaloids derived from P. harmala, especially harmine, demonstrate notable anticancer properties by targeting apoptosis, autophagy, abnormal cell proliferation, angiogenesis, metastasis, and cytotoxicity. Based on the collected information, P. harmala holds significant anticancer activity. Considering the mechanism of the various anticancer drugs and their acting similarity to P. harmala, the alkaloids derived from this herb, particularly harmine, can introduce as a novel anticancer medicine solely or in adjuvant cancer therapy.
How to Achieve Near Zero Fluoroscopy During Radiofrequency Ablation of Atrial Fibrillation: A Strategy Used at Two Centers
Authors: Haji Abdul Q. , Naji Mohammed B. , Jamal Shakeel , Kanjwal Khalil
Published: November 2020

Radiofrequency ablation for atrial fibrillation is currently the most effective rhythm control
strategy. These procedures, although safe, pose a risk for potential exposure to radiation and
can be time consuming. Radiation exposure during ablation can increase the risk of serious complications
in both patients as well as physicians. The overall procedure time also increases with use of
fluoroscopy. Advances in mapping technology, such as electroanatomic mapping, use of contact
force technology, intracardiac echocardiography and use of versatile sheaths and catheters has vastly
enhanced our ability to both shorten the procedure duration and minimize or even eliminate radiation
exposure. Use of near zero fluoroscopy technique is increasingly gaining acceptance in electrophysiology
centers. At this point, there is no uniform technique and various centers use individual
techniques based on their expertise and availability of various tools. There is need for a uniform
technique that is workflow friendly and widely accepted. There is a learning curve associated with
this technique and efforts should be made to incorporate zero fluoroscopic technique for ablation as
an essential part of electrophysiology training programs. In this paper, we present the strategy being
practiced at two centers, that involves a series of steps, to either decrease or eliminate the use
of fluoroscopy during atrial fibrillation ablation.
General Principles of the Surgical Management of Juvenile Inflammatory Arthritis
Authors: Figgie Mark P. , Kahn Barbara A. , Blevins Jason L. , Abdel Matthew P.
Published: November 2020

Surgical management of Juvenile Inflammatory Arthritis (JIA) presents many challenges for the patient, healthcare team and especially the orthopedic surgeon. Collaborative care efforts must be endorsed early on in order to facilitate maximal postoperative functional ability. Developmental levels, both physically and emotionally must be established preoperatively. It is important to determine bone age and growth plate closure to establish the best surgical intervention and avoid leg-length discrepancies later in life. Emotional maturity may impede the ability of the patient to manage pain or follow directions throughout the recuperative process. Surgical challenges require a team approach that includes rheumatologists who can manage disease modifying agents and the effects of discontinuing medications or planning surgery around dosing regimens in order to decrease immunosuppression. Managing multiple joint issues will require an expert team of occupational and physical therapists to prepare adaptive devices and rehabilitate patients who have significant functional limitations and decreased muscular strength. Because of an anticipated longer and more difficult recovery for JIA patients, case managers must engage in support systems and plan for postoperative care prior to surgery. Implant specific devices need to accommodate small bone structure, bone loss and complex deformities along with diaphyseal or epiphyseal dysplasia. Neurologic assessments will avoid cervical spine compromise during anesthesia administration. Bilateral procedures in the lower extremities should be considered whenever flexion contractures are present and should take place prior to upper extremity joint replacements. Restoring function to the hand and wrist takes priority over elbow and shoulder replacement, respectively. The key factors of appropriate surgical management in JIA patients are to decrease pain, restore function and avoid loss of ambulation at a young age. Extensive preoperative planning and communication with the patient, support system and healthcare team are warranted to address the complexities in this patient population.
Building a DNS Tunneling Dataset
Authors: Al-Drees Mohammed , Almasri Marwah M. , Al-Akhras Mousa , Alawairdhi Mohammed
Published: November 2020

Background:

Domain Name System (DNS) is considered the phone book of the Internet.
Its main goal is to translate a domain name to an IP address that the computer can understand. However,
DNS can be vulnerable to various kinds of attacks, such as DNS poisoning attacks and DNS
tunneling attacks.

Objective:

The main objective of this paper was to allow researchers to identify DNS tunnel traffic using
machine-learning algorithms. Training machine-learning algorithms to detect DNS tunnel traffic
and determine which protocol was used will help the community to speed up the process of detecting
such attacks.

Method:

In this paper, we considered the DNS tunneling attack. In addition, we discussed how attackers
can exploit this protocol to infiltrate data breaches from the network. The attack starts by encoding
data inside the DNS queries to the outside of the network. The malicious DNS server will receive
a small chunk of data decoding the payload and put it together at the server. The main concern is
that the DNS is a fundamental service that is not usually blocked by a firewall and receives less attention
from systems administrators due to a vast amount of traffic.

Results:

This paper investigates how this type of attack happens using the DNS tunneling tool by setting
up an environment consisting of compromised DNS servers and compromised hosts with the Iodine
tool installed in both machines. The generated dataset contains the traffic of HTTP, HTTPS,
SSH, SFTP, and POP3 protocols over the DNS. No features were removed from the dataset so that researchers
could utilize all features in the dataset.

Conclusion:

DNS tunneling remains a critical attack that needs more attention to address. DNS tunneled
environment allows us to understand how such an attack happens. We built the appropriate dataset
by simulating various attack scenarios using different protocols. The created dataset contains
PCAP, JSON, and CSV files to allow researchers to use different methods to detect tunnel traffic.
Application of WSN in Smart Grid: Present and Future Perspectives
Authors: Bulbul Abdullah Al-Mamun , Jibon Rayhan Habib , Rahaman Hasibur , Biswas Sandipa , Hossain Md. Bellal , Abdul Awal Md.
Published: November 2020

Modern life aims at making the world less vulnerable to risk, shortening our workload, saving
time, assuring security, and overall making our life more comfortable. These goals may be
achieved through the implementation of smart environments that are formed with different sensors
employed in the collection of various environmental data. The collaboration of these type of sensors is
known as Wireless Sensor Networks (WSN) that enhances the power generation system and serves
smartly. A wide range of studies suggests that WSN is an auspicious nomenclature that possesses the
capability of turning the traditional method of electric power generation, distribution, utilization monitoring
and measurement, fault tolerance, etc. into a smart one. However, the application of WSN in
the smart grid is not a feasible task. Several challenges have to be overcome to introduce WSN effectively
in the smart grid. This review begins with an in-depth discussion on the migration from the
conventional power grid to a Smart Grid (SG). Then, the introduction of WSN in SG benefits the conventional-
SG is discussed followed by the comparative analysis of the security demands, MAC layer
protocols, and routing protocols of WSN-based-SG. Finally, the communication technologies, future
motives, and intact fields of WSN-based-SG have been discussed in this review.
Benefaction of Herbals in the Management of Urolithiasis
Authors: Yadav Ankit , Das Rina , Mehta Dinesh Kumar , Yatin
Published: November 2020

:

Kidney stone formation or Urolithiasis is a common problem over many centuries with no guarantee of effective
treatment and, a high recurrence rate. Urolithiasis is precipitation of insoluble and less soluble salt such as Oxalate and
Phosphate in the urinary tract causing obstruction in the urethra resulting in renal colic and, hematuria.
Approximately, 10-12% of the population in industrialized countries are severely affected by Urinary stones. In, only a few
geographical areas is stone disease rare, e.g., in the coastal areas of Japan and Germany. It was believed that, 11% of people
in India are suffering from urinary stone problems, and approximately 50% of these cases may lead to severe renal damage.
Ultimately it causes severe health issues in terms of urinary tract obstruction, severe pain, and infection that adversely affects
the health of individuals.
Diuretics and narcotic analgesic like drugs which are used to prevent and cure urolithiasis are not effective in all cases and
are costly, give quite common recurrences, risk long term fertility and, other potential side effects are observed. So, humans
are forced return to Nature for safe remedies using herbal treatment. A great number of Indian medicinal plants have been
investigated in the treatment of urolithiasis, and they have been reported to be safe and effective.
In the present review, an effort has been made to highlight such herbal medicines which are potentially effective in the
management of urolithiasis.
Humane Education as a Method of Empathy Character for Children in School
Authors:   Psychology Study Program, Faculty of Social Studies and Culture, Gajayana University, Juliadilla Risa
Published: November 2020

The cases of animal abuse are escalating. The highlighted issue that indicates psychopathology is because of the lack of compassion for exploiting animals. Children with lack empathy and was familiar with the abusing act become a serious problem. To deal with the problem, humane education is a solution to maintain an effective way to cut the abusing behavior emotionally and cognitively within empathy and to have manners toward animals associates with animal welfare understanding. The program may set in a school and the suitable time to apply the program starts from nursery school to elementary school. Humane education is not only “about” animals but also “for” and “with” animals. The literature review aims to provide information on the definitions and procedures of humane education, debate, and solutions for their application in the educational setting and how humane education contributes to constructing empathy for children.
ACIS, A Novel KepTide™, Binds to ACE-2 Receptor and Inhibits the Infection of SARS-CoV2 Virus in vitro in Primate Kidney Cells: Therapeutic Implications for COVID-19 (Preprint)
Authors: Sotira Scientific Avik
Published: November 2020

UNSTRUCTURED

Coronavirus disease 2019 (COVID-19) is a severe acute respiratory syndrome (SARS) caused by a virus known as SARS-Coronavirus 2 (SARS-CoV2). Without a targeted-medicine, this disease has been causing a massive humanitarian crisis not only in terms of mortality, but also imposing a lasting damage to social life and economic progress of humankind. Therefore, an immediate therapeutic strategy needs to be intervened to mitigate this global crisis. Here, we report a novel KepTide™ (Knock-End Peptide) therapy that nullifies SARS-CoV2 infection. SARS-CoV2 employs its surface glycoprotein “spike” (S-glycoprotein) to interact with angiotensin converting enzyme-2 (ACE-2) receptor for its infection in host cells. Based on our in-silico-based homology modeling study validated with a recent X-ray crystallographic structure (PDB ID:6M0J), we have identified that a conserved motif of S-glycoprotein that intimately engages multiple hydrogen-bond (H-bond) interactions with ACE-2 enzyme. Accordingly, we designed a peptide, termed as ACIS (ACE-2 Inhibitory motif of Spike), that displayed significant affinity towards ACE-2 enzyme as confirmed by biochemical assays such as BLItz and fluorescence polarization assays. Interestingly, more than one biochemical modifications were adopted in ACIS in order to enhance the inhibitory action of ACIS and hence called as KEpTide™. Consequently, a monolayer invasion assay, plaque assay and dual immunofluorescence analysis further revealed that KEpTide™ efficiently mitigated the infection of SARS-CoV2 in vitro in VERO E6 cells. Finally, evaluating the relative abundance of ACIS in lungs and the potential side-effects in vivo in mice, our current study discovers a novel KepTide™ therapy that is safe, stable, and robust to attenuate the infection of SARS-CoV2 virus if administered intranasally.

INTERNATIONAL REGISTERED REPORT

RR2-https://doi.org/10.1101/2020.10.13.337584
Gerakan Remaja Sehat di Dukuh Gedongan (GEMAS DONG)
Authors: Ema Waliyanti  , Sutantri Sutantri , Oktaviyanti Mahrika , Shafira Wilda
Published: November 2020

Remaja merupakan usia rentan di mana pada masa ini remaja mempersiapkan diri untuk memasuki masa dewasa, remaja dipandang sebagai suatu masa dimana individu telah mencapai kematangan dalam proses perkembangannya. Banyak hal yang terjadi selama rentang masa remaja, diantaranya kematangan secara seksual maupun perubahan tingkah laku, sikap, dan nilai-nilai. Dukuh Gedongan berada di Kelurahan Bangunjiwo, Kecamatan Kasihan, Bantul. Hasil pengkajian di tiga RT menujukkan bahwa terdapat total 327 jiwa dengan total remaja sebanyak 89 jiwa atau 24%. Selain itu berdasarkan hasil pengkajian ditemukan sebanyak 45% warga merokok. Oleh karena itu pendidikan kesehatan (edukasi) dan skrining kesehatan dengan sasaran remaja perlu dilaksanakan. Hasil dari kegiatan Gerakan Remaja Sehat di Dukuh Gedongan (GEMAS DONG) menunjukan bahwa mayoritas remaja memiliki tekanan darah dalam rentang normal sebanyak 17 orang (85%), hasil skrining dengan menggunakan alat smokerlyzer menunjukkan bahwa dua orang perokok ringan dan satu orang perokok sedang. Selain itu dari kegiatan penkes terkait pergaulan bebas, rokok elektronik, dan manajemen stres menunjukan peningkatan pengetahuan yang ditandai dengan peningkatan skor rerata post-test dibandingkat pre-test. Kegiatan GEMAS DONG di Dukuh Gedongan merupakan salah satu bentuk kegiatan yang dapat digunakan dalam upaya penigkatan pengetahuan serta kesehatan remaja.
Pelatihan Pembelajaran Biologi Berbasis ICT bagi Guru Muhammadiyah DKI Jakarta
Authors: Maesaroh Maesaroh , Gufron Amirullah  , Eka Kartikawati  , Mega Elvianasti
Published: November 2020

Perkembangan teknologi informasi dan komunikasi atau Information and Communication of Technology (ICT) tidak dipungkiri telah memasuki berbagai lini kehidupan, salah satunya dalam bidang pendidikan. Sistem teknologi informasi dan komunikasi dapat digunakan hampir pada semua sektor manajemnen pendidikan. Meluasnya pemanfaatan teknologi informasi dan komunikasi berdampak pada karakter peserta didik. Hal ini menjadikan proses pembelajaran yang menggunakan model pembelajaran yang up to date atau berbasis ICT. Perbedaan generasi antara pendidik atau guru dan peserta didik dapat menghasilkan sebuah gap dalam komunikasi belajar atau penyampaian materi yang efektif dan efisien. Dalam hal ini akan lebih baik jika guru dapat mengimbangi atau menyamakan pengetahuan dan keterampilan dalam bidang ICT guna pencapaian tujuan pembelajaran dengan baik. Kegiatan pengabdian pada masyarakat ini menggunakan metode pelatihan yang bekerjasama dengan majlis Dikdasmen PWM Muhammadiyah DKI Jakarta. Diketahui bahwa 1) penggunaan perangkat pembelajaran berbasis ICT diantaranya yang berupa personal Computer, Proyektor, Compact Disc, Internet dan Software dalam pembelajaran rutin oleh guru Biologi peserta pelatihan sebanyak  47 %; 2) seluruh peserta pelatihan pembelajaran biologi berbasis ICT menyatakan bahwa kegiatan ini bermanfaat untuk mereka sebagai guru biologi dengan persentase jawaban sebanyak 100 %. Hal ini menunjukkan bahwa guru bersemangat dan memiliki kemauan untuk belajar meningkatkan kompetensi terkait dengan pembelajaran berbasis ICT.
Pendampingan dalam Implementasi Strategi Pemasaran Produk Olahan Susu Sapi
Authors: Garside Annisa Kesy , Amallynda Ikhlasul
Published: November 2020

Usaha Bunda is a small home industry producing several cow’s milk processed products located at Maron village, Pujon Kidul, Malang. The challenge faced by this owner is the marketing aspect to define the right marketing strategy to expand the coverage and increase competitiveness. The goal of this community dedication is to help formulating and implementing the marketing strategy for the Usaha Bunda home industry. The approach is advocation in the  form of assistance. Several strategy proposed was consignation with several gift shops and tourist attraction, redesign the product packaging, and creating an online shop. The outcome of assistance in marketing strategy implementation was the owner’s better understanding on the knowledge and skill of product packaging and online marketing. Additionally, the owner also confirmed that there has been an omzet increase of 1.5 to 2 times as the result of the new packaging. The online shop opened at Tokopedia marketplace also helps to expand the product promotion and market coverage without geographical and time limitation.
Penggunaan Sistem Penjaring Informasi Hoaks dalam Menerapkan Pendidikan Anti-Hoaks bagi Guru di Masa Pandemi COVID-19
Authors: Ramadhani Rahmi , Meizar Abdul , Ardiyanti Dwi
Published: November 2020

Permasalahan yang dialami sekolah mitra diperoleh melalui observasi dan wawancara, diantaranya guru mitra mengalami kesulitan dalam mencari sumber referensi pembelajaran yang valid dan terpercaya untuk digunakan dalam materi pembelajaran selama proses pembelajaran daring. Guru mitra juga sering memperoleh tautan yang mengandung informasi yang belum dapat dipercaya dan dikhawatirkan masuk dalam kategori informasi hoaks. Berdasarkan permasalahan tersebut, Tim PKM melaksanakan kegiatan program kemitraan masyarakat dengan tujuan untuk memberikan pelatihan dan pendampingan penerapan sistem penjaring informasi hoaks sebagai upaya untuk menerapkan pendidikan anti-hoaks bagi guru-guru selama proses pembelajaran jarak jauh berbasis daring di masa pandemi COVID-19. Jumlah peserta kegiatan PKM ini adalah sebanyak 28 orang guru.Target luaran kegiatan PKM ini adalah (1) terdapat peningkatan dan pemahaman para guru terkait informasi hoaks yang bererdar di media sosial maupun media berita online lainnya; (2) terdapat peningkatan keterampilan guru dalam menggunakan aplikasi sistem penjaring informasi hoaks yang telah dirancang oleh Tim PKM; (3) peningkatan keterampilan guru dalam melakukan proses penjaringan informasi hoaks menggunakan aplikasi dan melakukan proses pengecekan terkait informasi yang diperoleh melalui penelusuran online; serta (4) peningkatan motivasi dan semangat guru dalam menerapkan Pendidikan anti-hoaks dalam proses pembelajaran jarak jauh selama masa pandemi COVID-19. Hasil yang diperoleh dari kegiatan PKM ini adalah (1) para guru mampu melakukan pemilihan informasi yang akan digunakan dalam proses pembelajaran jarak jauh; (2) para guru mampu menggunakan aplikasi sistem penjaring informasi hoaks; dan (3) para guru mampu menerapkan Pendidikan anti-hoaks dalam proses pembelajaran baik selama masa pandemic COVID-19 maupun masa New Normal.
E-Santri Sebagai Aplikasi Pembelanjaan dan Pembayaran Mandiri oleh Santri di Pondok Pesantren Az Zubair
Authors: Moh Zayyadi  , Abd Wahab Syahroni
Published: November 2020

Transaksi belanja, sanksi dan pembayaran di Pondok Pesantren Az Zubair masih menggunakan sistem transaksi manual yaitu menggunakan catatan manual dan uang tunai. Beberapa transaksi yang ada di Pondok Pesantren antara lain transaksi pembayaran kewajiban bulanan, mini market atau kantin, pembayaran jasa dan pembayaran denda atau hukuman. Transaksi yang dilakukan secara manual sangat rawan pencurian dan susah dilacak, sulit melakukan rekapitulasi serta bisa menjadi salah satu penularan kuman, bakteri atau virus yang menempel pada uang tunai. Penerapan aplikasi eSantri sebagai aplikasi pembelanjaan dan pembayaran mandiri oleh santri di Pondok Pesantren Az Zubair bertujuan memberikan informasi secara terbuka dan langsung kepada santri terkait tagihan pembayaran kewajiban santri, melatih santri agar terbiasa dengan transaksi non tunai meskipun hanya dilakukan dalam jaringan lokal pondok pesantren dengan menggunakan kartu santri yang didalamnya terdapat password dan saldo. Metode pelaksanaan yang digunakan adalah sosialisasi dan pelatihan dan metode pengembangan aplikasi menggunakan metode prototype. Setelah aplikasi selesai dibuat, tim pengabdian melakukan pelatihan kepada santri, selain itu tim pengabdian juga telah membuatkan buku panduan penggunaan aplikasi eSantri. Kegiatan pengabdian ini dilakukan mulai april hingga agustus 2020. Berdasarkan hasil survey kepada 80 responden menggunakan skala likert terhadap implementasi aplikasi eSantri di pondok pesantren menyatakan sangat setuju dengan kegiatan pengabdian ini dengan nilai persentasi kepuasan sebesar 81,75%.
Free competition in the digital economy: mechanisms of protection
Authors:   Russian Presidential Academy of National Economy and Public Administration, CHEPURNOVA NATALIA М. , MURYSEVA VALENTINA O. ,   Russian Presidential Academy of National Economy and Public Administration
Published: November 2020

The article presents various approaches to the concept of ‘digital economy’, offers the author’s definition, identifies the features of state protection of competition in the context of digital economy, describes the procedure for conducting economic activities and maintaining competition in the commodity markets in the context of the development of information and communication technologies, reveals the features of the state mechanism for protecting competition in the conditions of digitalization of production of goods and services. It justifies the need to develop a holistic organizational and legal mechanism of public administration, taking into account the processes of globalization of the digital economy, and the need to change legislative approaches to ensure that new entities are taken into account in the field of competition and the coverage of public relations. Analyzing the normative legal acts of the Russian Federation related to the concept of Big Data and the processing of large amounts of data, the authors come to the conclusion about expediency of amending the clauses of the Decree of the President of the Russian Federation ‘On the Strategy of information society development in Russian Federation to 2017 – 2030’ in the part on definition of the digital economy.
Social entrepreneurship in Russia: problems and prospects
Authors:   Roscongress Foundation, ISAEV DMITRY V.
Published: November 2020

The article is devoted to the problems and prospects of the development of social entrepreneurship in Russia. The author notes the need to stimulate this kind of activity and create an appropriate institutional and regulatory legal framework. However, there is no common understanding and definition of ‘social entrepreneurship’, which gives the existing experience and scientific research a fragmented character. In practice, the concept of social entrepreneurship as an activity aimed at generating commercial profit, rather than creating social value and solving social problems, is widespread. The article gives an attempt to identify the causes of this condition, analyzes existing research approaches and practical experience, as well as draws the appropriate conclusions and offers recommendations. The existing traditional and modern approaches to the interpretation of entrepreneurship as a special type of human activity are analyzed. The analysis showed that entrepreneurial activity is traditionally associated with innovation, risk, uncertainty and entrepreneurial profit. Particular attention is paid to existing research approaches to the study of ‘social entrepreneurship’ as a modern phenomenon. The characteristic features of ‘social entrepreneurship’ that distinguish it from other types of entrepreneurial activity are identified, the definitions existing in the Russian scientific environment that are most common when trying to draw up the theoretical and conceptual foundations of social entrepreneurship are highlighted. As a Russian experience, the activities of the non-profit partnership ‘The World of the Older Generation’, which not only unites social entrepreneurs, but also operates as an institution for the development of the social sphere, are considered. Conclusions are made about the research prospects in this area and directions for further study of social entrepreneurship are proposed. The author suggests examining the experience of social entrepreneurship accumulated in Russia when formulating recommendations for the further development of the regulatory framework.
Directors with multiple directorships and accounting conservatism: Evidence from banks in South Asia
Authors: Kutubi Shawgat
Published: November 2020

This study investigates the effect of directors with multiple directorships on banks’ financial reporting conservatism in South Asia (Bangladesh, India, Pakistan, and Sri Lanka). The paper applied Basu (1997) asymmetric timeliness measure of conditional conservatism for a sample of 93 banks stock listed banks of the four countries. We find that the relationship between directors with multiple directorships and accounting conservatism is an inverse ‘U’ shape. That is, at a low level of multiple directorships, banks follow conservatism in financial reporting (reputation effect), then at a high level of multiple directorships reporting conservatism declines (busyness effect). We also find an optimal level of multiple directorships at which directors influence the most on financial reporting conservatism. In further analysis, the study finds evidence that directors with multiple directorships (DWMDs) in banks with high insolvency risk follow accounting conservatism. The findings of this study remain robust when we modify the definition of multiple directorships and control for multiple directorships by bank chairs and insolvency risk under alternative settings
An unusual case of Chronic Lymphocytic Leukemia with trisomy 12 presenting with prolymphocytic transformation and new translocation 8;21.
Authors: Bhushan Mishi , Kumar Kirthi
Published: November 2020

Patient with a long history of CLL and known trisomy 12 presented with
rapidly rising lymphocytosis, bulky adenopathy, and splenomegaly.
Peripheral blood and bone marrow exam showed preponderance of
prolymphocytes. Cytogenetic analysis showed an abnormal male karyotype
with trisomy 12 and a new t(8;21) translocation in the same 6
metaphases.
Plastic response to early shade avoidance cues has season-long effect on Beta vulgaris growth and development
Authors: Adjesiwor Albert , Ballenger Joseph , Weinig Cynthia , Ewers Brent E. , Kniss Andrew
Published: November 2020

Early emerging weeds are known to negatively affect crop growth but the
mechanisms by which weeds reduce crop yield are not fully understood. In
a 4-yr study, we evaluated the duration of weed-reflected light on sugar
beet (Beta vulgaris L.) growth and development. The study included an
early-season weed removal series and a late-season weed addition series
of treatments arranged in a randomized complete block, and the study
design ensured minimal direct resource competition. If weeds were
present from emergence until the two true-leaf sugar beet stage, sugar
beet leaf area was reduced 22%, leaf biomass reduced 25%, and root
biomass reduced 32% compared to sugar beet grown season-long without
surrounding weeds. Leaf area, leaf biomass, and root biomass were
similar whether weeds were removed at the two true-leaf stage
(approximately 330 GDD after planting) or allowed to remain until sugar
beet harvest (approximately 1240 GDD after planting). Adding weeds at
the two true-leaf stage and leaving them until harvest
(~1240 GDD) reduced sugar beet leaf and root biomass by
18 and 23%, respectively. It appears sugar beet responded to weed
presence by adjusting carbon allocation and leaf orientation to optimize
light interception.
Comparison with tube core and Magill forceps for nasotracheal intubation: a randomized controlled trial
Authors: Hu Rui , Niu Jingyi , Wu Lining , Sun Hao , Sun Peng , Huang Jiaying , Yu Junma
Published: November 2020

Objective: Magill forceps are frequently used to complete the process of
nasotracheal intubation (NTI). We aimed to identify a tube core that
could facilitate the NTI process conveniently without Magill forceps.
Methods: Sixty patients scheduled for oral and maxillofacial surgeries
with no differences between the two groups (30 per group) with regard to
demographic data were enrolled in our study. In Group M, the
wire-reinforced endotracheal catheter was inserted into the trachea
using Magill forceps. However, in Group T, a tube core bent to the
physiological curve of the nasal cavity lubricated with aseptic paraffin
oil was inserted into the endotracheal catheter, and it was then
withdrawn after the endotracheal catheter was advanced through the
glottis under direct vision. Results: All NTIs were completed
successfully, and no Magill forceps were used in Group T. There was a
significant difference in total NTI time between the two groups (Group
M, 59.7 (5.1) sec vs Group T, 52.4 (3.1) sec). Mild epistaxis was
observed in 6 patients in Group M and 5 patients in Group T (6/30 vs
5/30, respectively). There was no presence of damaged oral tissue or
damage to the teeth in either group. Conclusion: We conclude that using
the tube core, which is a disposable sterilised stylet, for NTI is a
convenient choice.
Tracheocutaneous fistula- A surgical challenge
Authors: CHIRAKKAL PRAMOD , Hail Amira Al
Published: November 2020

We are experienced a challenge for the surgeon for tracheocutaneous
fistula closure in managing such a complication such as chronic cough,
infection and other co-morbidities. The need for a secondary closure is
also warranted when the stoma does not close on itself within a
specified time.