bluuebunny/crossref_metadata_2025 huggingface dataset:
Docking studies between Natural unsaturated Oleic-acid and a de novo lung cancer peptide of CHRNA3 (Cholinergic Receptor Nicotinic Alpha 3) using Insilico protocols
Authors: - Aadya. LN
Published: January 2025

Abstract
Lung cancer, according to current clinical pharmacological studies, is among the most prevalent types of cancer. Polymorphisms in CHRNA3 gene have been associated with an increased risk of smoking initiation and an increased susceptibility to lung cancer. In the current Insilico study, there were two major findings. First, the novel 3D peptide was designed from the genomic sequence of CHRNA3. Next, we observe how Oleic acid interacts with the derived cancer peptide using Insilico tools. The exonic sequence of CHRNA3 was converted into a protein sequence which subject to peptide designing using immuno-medicine protocols. The peptide was modelled using an automated homology modelling server. The binding affinities between the control drug, 5-Fluorouracil and the test compound, Oleic-acid with CHRNA3 can be found using CB Dock, an automated drug docking server. The docking results clearly elucidated that when compared to the existing anti-cancer drug, 5-flourouracil, Oleic acid showed a higher binding affinity with CHRNA3. Hence, Oleic acid can be added as a supplementary drug to existing drugs to enhance their efficiency. Oleic acid, being a natural compound, one can expect lesser side-effects. Our 3D novel peptide structure will be available in PDB-Dev (https://www.modelarchive.org/doi/10.5452/ma-m1plw). Our study clearly revealed that Oleic acid is a potential therapeutic agent for Lung Carcinoma.
To Study the Prevalence of Colonization and Infection by Candida Species in Intensive Care Units at Tertiary Care Hospital, India.
Authors: - Neha Patil , - Dr.Deepashri Naik
Published: January 2025

Fungi, especially Candida species, pose significant health risks in ICUs, contributing to increased morbidity and mortality. Candidiasis, particularly candidemia, is concerning in critically ill patients, with a rise in non-albicans Candida isolates leading to treatment failures. Candida auris presents a serious nosocomial risk, necessitating intensive screening. This study aims to assess the prevalence of Candida colonization and infection in ICU settings. Two swabs were collected from each patient—one from skin lesions and one from non-lesion areas. Of the 280 swabs, 81 showed Candida growth, with 43 from lesion areas. Prolonged ICU stays and ventilator use were identified as significant risk factors. Candida infections are more prevalent in middle-aged to older adults and males, emphasizing the need for infection control measures.
THE PROCESS OF PROCESSING CASSAVA INTO MOCAF FLOUR
Authors: Sahda Rona Taqiyya , Sri Hartuti
Published: January 2025

Mocaf flour is a local product that can be utilized as an alternative to wheat flour in various food products. Using local food sources, such as cassava, is essential to support food security and reduce dependence on imports. This article is a review examining various methods of processing cassava into Mocaf flour. Mocaf flour is a cassava-based product with the potential to replace wheat flour. The Mocaf processing method consists of several stages, including sorting, peeling, washing, cutting, fermentation, drying, milling, and sieving, which result in high-quality flour with improved texture and flavor. A critical stage in the production of Mocaf flour is the fermentation process. Cassava fermentation can be done using microbes, such as Lactobacillus plantarum bacteria and tape yeast, or through non-microbial fermentation. This fermentation process alters the physicochemical properties of cassava, enhancing viscosity, and rehydration capacity, and reducing its bitterness.
PENERAPAN SISTEM INFORMASI AKUNTANSI ATAS SIKLUS PENDAPATAN PADA USAHA BUDIDAYA IKAN LELE PAK WIDODO
Authors: Lestari Amanda Rizki , Pertiwi Nazhwa Aulia Putri , Kaliky Saraun , Suatrian Alya Tiara , Samalehu Ainun Ayu
Published: January 2025

This service aims to implement Accounting Information System Design (Income Cycle) in Pak Widodo's catfish cultivation business. The application of an accounting information system for the revenue cycle is needed by companies to make decisions in company development. This service takes as its object Mr. Widodo's Catfish Business in the Gadihu Complex, Ambon City. This business has been established since February 2023. Pak Widodo's catfish cultivation business is a business that operates in the field of fish cultivation or aquaculture. Several stages used are research subjects, data collection techniques, data retrieval techniques, cycle design stage and finally the cycle design stage. The result of this service activity is the design of an Information System in the form of a Data Flow Diagram (DFD) and Flowchart which describes the income cycle of Mr. Widodo's Catfish Cultivation business. So that it can help the business in its business operational processes.
PERANCANGAN SISTEM INFORMASI AKUNTANSI SIKLUS PENGGAJIAN PADA PT MALUKU PRIMA MAKMUR
Authors: Rary Rhoulanda , Telaumbenua Kristiani , Tehuayo Rosmalia , Buton Ririn , Buton Arniati
Published: January 2025

The Community Service Activity (PKM) aims to analyze the accounting information system in the payroll cycle at PT Maluku Prima Makmur (PT MPM) using the interview method. This method is chosen because it can provide accurate information about the payroll cycle process at PT MPM. The result of this PKM activity is the development of a Context Level Data Flow Diagram (DFD) that will be further developed into Level 0 DFD that will depict the complete and detailed process of the payroll cycle.
PENDAMPINGAN PERANCANGAN SISTEM INFORMASI AKUNTANSI ATAS SIKLUS PENGGAJIAN PADA WALLANG RESTO
Authors: Latuconsina Muhammad Syedek , Apriyanti  , Hahury Ridolvo Ashley , Ahmad Nadia , Berutu Yesika , Safarudin Ardian
Published: January 2025

The purpose of this community service is to design an Accounting Information System, which is in the form of a DFD that provides an overview of the flow of activities, especially the payroll flow in Wallang Resto, which can later help the public to know about how the stages of payroll flow in Wallang Resto, and can facilitate the performance of manager or owners in the Payroll process. With the presence of this dedication, it is hoped that Wallang Resto owners can implement and develop a more effective payroll system, and can help owners and employees know about the description of the payroll system in Wallang Resto. In the creation of this system, we used the Ms. Visio Programming Application which was used to draw DFDs.
PENGABDIAN KEPADA UMKM DALAM MENGANALISIS SISTEM INFORMASI AKUNTANSI SIKLUS PENDAPATAN MENGGUNAKAN DFD PADA USAHA JAJANAN UMSAAD
Authors: Manuji Masyita Salshabilla , Shahadah Isroiatus , Palpialy Greace Meicy , Maruapey Issyaina Zaitunia , Marlin Ari , Luhulima Daniel
Published: January 2025

Income is important in running a business. In order for a business to run in a systematic and structured manner, an accounting information system is needed. Nowadays many businesses run their business systems manually. This service was undertaken to design an accounting information system, which facilitated the operation of the income cycle. The object of this service is Jajanan Umsaad business located on Jl. Sultan Babullah, Lorong Silale, RT 03 RW 004. Jajan Umsaad is a business that has many transactions and needs a system to help ease the performance of Micro, Small, and Medium Enterprises. This service chooses the income cycle because the main part in the business flow and income is an important part of the business spin-off. This service resulted in a draft of the income cycle accounting information system from the business of Jajanan Umsaad, which assisted in the process of business transactions. This business design is described using DFD (DATA FLOW DIAGRAM).
EVALUASI PENGENDALIAN INTERNAL SIKLUS PRODUKSI PADA WALANG RESTO SEAFOOD
Authors: Laga Dimara D , Huwae Ronansi , Difinubun Windi R , Sulaiman Adhar Furqan A , Thenu Celvin J
Published: January 2025

The aim of this service is to create a clear and structured data flow, as well as design a Data Flow Diagram (DFD) that describes the steps and decision making in the seafood production cycle. Through good integration between AIS and the production cycle, Warung Resto can improve operational efficiency, service quality and financial balance. This service involves subjects at Warung Resto, with data collection techniques through interviews and observation of the production cycle. Based on the results of service, Warung Resto has structured employee management, financial performance that depends on income, and unique selling points that attract customers. However, the impact of the COVID-19 pandemic presents new challenges for this business. Thus, community service for seafood stalls is carried out using a production cycle that involves several stages, such as preparation, training, management and supervision. DFD describes production cycle activities from suppliers to raw material selection.
PENERAPAN SISTEM INFORMASI AKUNTANSI ATAS SIKLUS PENGELUARAN PADA USAHA KULINER BY MAGZ
Authors: Ulmasembun Prasantya M , Said Octa Ramadhani , Syamsuddin Yuliana Rahmanillah , Matdoan Putri Rahma Amalia
Published: January 2025

Currently, in this era of digitalization, there are still many businesses whose information systems are still manual. This community service aims to help and direct the design of accounting information systems, which can simplify expenditure cycle operations. The object of this activity is the Culinay by Magz which is located in Pattimura Park, Ambon City. Culinary by Magz is a business that has many transactions that require an accounting information system that makes the performance of this business easier. This activity has an expenditure cycle because the expenditure cycle is a basic cycle and a very important cycle that must be paid attention to because it is very important in a business. In this community service, a design for an accounting information system for the culinary businesses was produced by Magz. The design if the accounting information system cycle is depicted using a DFD (Data Flow Diagram).
PERENCANAAN SISTEM INFORMASI AKUNTANSI SIKLUS PENDAPATAN PADA UMKM CV FAJAR
Authors: Rifai Afia Maulani , Lestari Andini , Ahmad Dwi Nursyafni , Mahulete Yumna
Published: January 2025

The purpose of this community service is to design an accounting information system in the revenue cycle. Accounting information systems in the revenue cycle play an important role in the decision-making process for the development of a company. In this study, the business object taken is CV Fajar which was founded in 2014. This business is engaged in trade where this business receives supplies of crops and then imports according to customer demand. In this study, the method used is qualitative. From the results of the study, it was found that recording transactions are still done manually and not under accounting standards.
ANALISIS SITEM INFORMASI AKUNTANSI SIKLUS PRODUKSI PADA ABON IKAN YANAIN
Authors: Rieuwpassa Ariel C F , Tunjanan Julius Kwartus , Ngilyaubun Jhon Bryan , Unawekly Aprilian J , Limasana Orlando
Published: January 2025

This community service aims to analyze the accounting information system used on the production cycle at the Yanain Fish Floss UMKM. This activity method used is direct observation and interviews with the aim of gaining an in-depth understanding of the production process and the information system used within the company. Yanain Fish Abon is a small trading company operating in the culinary sector. This company was founded by Mince Noya in 2003, located on Jl. Rijali, RT.001/RW.004, Kel Karang Panjang, Kec. Sirimau, Ambon City, Maluku. More precisely, next to the Ambon District Prosecutor's Office. From this research, an Information System design was produced Accounting for Yanain Fish Floss MSMEs, which will help the production process for MSMEs Yanain Fish Floss. The production cycle in the Yanain Fish Floss business has its own activities which are described in the production cycle, namely in the context DFD, level 0 DFD, and flowchart which will be used to design the database system
PERANCANGAN SISTEM INFORMASI PADA SIKLUS PENDAPATAN RUMAH MAKAN RASA GURIH
Authors: Nuriyati Wa , Rumbia Rani , Alimuna Ririn F , Soulisa Husna , Derlen Saripa , Melmambessy Hermalina S
Published: January 2025

Rasa Gurih restaurant is one of the restaurants that processes various kinds of marine biota products in Maluku. The purpose of this community service is to assist in preparing the income system and design the income system and internal controls that must be used in rasa gurih restaurants. The method used in this community service is a qualitative method. Data collection methods were carried out using interviews, observations and documentation at rasa gurih restaurants. The results of this community service created an income cycle accounting information system to make it easier for admins to control and calculate income at the restaurants
POTENTIAL REVIEW ASESSMENT PENGASUH PADA PENDIDIKAN FORMAL GEREJA (SEKOLAH MINGGU) DI TINGKAT KLASIS KOTA AMBON
Authors: Korlefura Criezta , Haumahu Cynthia Petra
Published: January 2025

One of the non-formal educational institutions is Sunday School (SM) where SM provides education in the field of religion, especially aimed at developing the personality of SM children. Based on the observations made, there are problems that occur in SM, namely that the abilities of SM caregivers vary due to their varying educational backgrounds. The quality and quantity of SM caregivers must be in accordance with SM's own needs, so that they are effective and efficient in supporting the achievement of SM goals. Therefore, the most important thing is the process of evaluating the abilities, knowledge and interests of caregivers before they are placed at the right level of care so that the implementation of teaching and learning in SM can be more efficient and effective. Based on the explanation above, SM caregivers in the Ambon City Classroom were selected as pilots in implementing the potential review assessment. Mahanaim Region SM is one of the SMs under the auspices of SMTPI in the Ambon City Classis. The training obtained the results of a potential review assessment where the implementation of this assessment for caregivers who were just about to join or for caregivers who still had a short period of service (less than 2 years) were able to evaluate their abilities and be placed according to the basic abilities they had previously.
Pendampingan Perancangan Siklus Penggajian Pada UD Sinar Baru
Authors: Latumaerissa Sabrina , Sapasuru Silvia , Telehala Leony , Kailola Christalia
Published: January 2025

Payroll is an important thing as a form of remuneration for the company to its employees. The community service location is at UD Sinar Baru in Ambon, Maluku. This community service uses descriptive qualitative research using primary data and secondary data. The community service subjects consisted of three resource persons, namely the business owner and two employees. Data was collected through interviews, observation, and documentation. The results of the study indicate that the payroll process in the UD Sinar Baru uses a manual system, this can lead to potential fraud or negligence at the stage of attendance and submission of employee salaries. In conclusion, the design of a payroll accounting information system at UD Sinar Baru is in accordance with accounting theory in general.
ANALISIS SISTEM INFORMASI AKUNTANSI SIKLUS PENDAPATAN WARUNG MAKAN RINDU MALAM
Authors: Tuharea Gigi Fatmawati , Tuasamu Ira , Rumakur Nur Asia , Nurmin
Published: January 2025

The development of the business world today is greatly influenced by the development of information technology. This has created new opportunities and helped in improving efficiency and accuracy in managing accounting information, especially in terms of income. The analysis technique used in this research is qualitative descriptive analysis. This technique is used to provide a detailed description of the characteristics, patterns and distribution of data. Based on the results of the MSME service to the Miss Night food stall, it was concluded that the service activity aimed to design an accounting information system, namely data flow diagrams and flowcharts for the revenue cycle of the Miss Night food stall. Accounting information systems in the revenue cycle help in more efficient and accurate order processing. Automation in the process of checking order availability, creating invoices, and recording revenue helps save time and effort.
AKSI KOLEKTIF KELOMPOK TANI DALAM PENGEMBANGAN USAHA TANI AGROFORESTRI DI NEGERI HATIVE BESAR KOTA AMBON
Authors: Sahureka Mersiana , Latupapua Lesly
Published: January 2025

Community Service Activities (PkM) were carried out in Hative Besar, Ambon City in November 2023 with the aim of transferring knowledge and technology to the community regarding agroforestry management patterns and the importance of collective action in developing farming businesses. The methods used in PkM activities are observation, counseling and training/tutorial methods. Observation results show that there are 2 planting patterns applied by farmers in Hative Besar in managing hamlets, namely the fence planting pattern (Trees Along Bolders) and the random mixed planting pattern (Mixture randome). The PKM activities carried out by the team through counseling and training/tutorials have had a positive impact on the community, namely increasing the community's knowledge about "dusung" agroforestry management and developing agricultural products. Apart from mutual cooperation (masohi) as a form of collective action, farmer groups must be maintained by the community as a cultural value and local wisdom.
METODE FORECASTING PENDAPATAN WARUNG MAKAN DENGAN MENGGUNAKAN METODE LEAST SQUARE
Authors: Mantouw Rosdiana Yudith , Behuku Gloria Ivana , Dewanti Ayu , Juliani Tri Neira , Birahy Fionety T , Pihahei Hobertina Geofany
Published: January 2025

Kegiatan pengabdian kepada masyarakat (PKM) ini bertujuan untuk meramalkan pendapatan "Warung Makan Padang Ayah Poka" dengan menggunakan metode Least square. Pemilihan metode ini didasarkan pada kemampuannya dalam menghasilkan prediksi yang akurat melalui anlisis tren data historis. Data yang digunakan dalam penelitian ini mencangkup pendapatan bulanan warung makan selama tujuh bulan kedepan. Proses analisis dimulai dengan pengumpulan data pendapatan, diikuti dengan penerapan metode Least Square untuk mengidentifikasi  pola tren dalam data tersebut. Selanjutnya , model matematika dibangun berdasarkan hasil analisis untuk memperkirakan pendapatan masa depan.
ANALISIS PERAMALAN PENJUALAN DENGAN METODE LEAST SQUARE PADA AZZIKRA MEBEL
Authors: Pawae Nurafni Mutia , Tomia Sindy Syafitri , Resky Reyhan , Saputra Rafly Aditya
Published: January 2025

Azzikra Mebel is a furniture business located in Poka, Wailela, which has been involved in the furniture business since 2006 and is a business engaged in the manufacture of wood-based furniture, such as chairs, cupboards, doors, windows, kitchen sets and others, according to customer orders. By having sales data every month, the company must be able to predict sales well. The problem that companies generally face is how to predict future sales based on past sales data. This prediction greatly influences the decision to determine the amount of wood required. provided by the company. Therefore, the company must apply a method that can estimate the size of the movement of sales data in the future, called the forecasting method that will be used to predict sales in this case is the Least Square method. The results of this research are the prediction results for the predicted month, namely June - December. With sales of 10,000,000 in June, 10.300,000 in July. 100,600,000 in August, 10,650,000 in September, 11,088,887 in October, 11,372,214 in November, and 12,637,388 in December, which can later be used as a reference for sales preparations for that year and beyond
PELATIHAN PENERAPAN LIFE CYCLE ASSESMENT HOME INDUSTRY TAHU WAYARI
Authors: Mandaku Hanok , Rasyid Mentari
Published: January 2025

Home Tofu Industry Wayari has been carrying out its production process since 2021. The tofu production process starts from soaking, washing, grinding, boiling/cooking, filtering (separating the juice and dregs), freezing, molding and pressing, and cutting. Every production process produces industrial waste, both in the form of solid and liquid waste. Solid waste is sold and used as animal feed, while liquid waste is disposed of through sewers. Liquid waste causes environmental problems such as strong odors. So it is necessary to handle the liquid waste produced from the tofu production process to minimize negative impacts on humans and the surrounding environment. One approach that can be used is a life cycle assessment to determine potential dangers resulting from production activities that produce waste.
Analiza wysokości opadów maksymalnych z modelu PMAXTP i ich zastosowanie do weryfikacji działania miejskiego systemu odwodnienia = Analysis of maximum rainfall amounts from the PMAXTP model, and their application in verifying the performance of an urban drainage system
Authors: Barszcz Mariusz Paweł , Kaznowska Ewa , Wasilewicz Michał
Published: January 2025

Prawidłowe wyznaczenie wielkości opadu deszczowego na obszarze zlewni, w kontekście czasu jego trwania i prawdopodobieństwa przewyższenia, stanowi podstawę projektowania, weryfikacji i eksploatacji systemów odwodnieniowych (kanalizacyjnych) w miastach. Opracowanie i wdrożenie przez IMGW-PIB w 2022 r. modeli opadowych PMAXTP, obejmujących swoim zasięgiem całą Polskę, umożliwia bezpłatny dostęp do aktualnych i wiarygodnych informacji o lokalnych wysokościach (natężeniach) opadów maksymalnych. W pracy przedstawiono wyniki analiz, które obejmowały porównanie wysokości opadów o określonych charakterystykach (czasach trwania w zakresie 54320 min oraz prawdopodobieństwach 250%), wyznaczonych z modelu PMAXTP dla stacji meteorologicznej Warszawa-Bielany, względem korespondujących wielkości z tradycyjnie dotychczas stosowanych modeli Błaszczyka i Bogdanowicz-Stachý. Przeprowadzone analizy obejmowały również weryfikację przestrzennej zmienności opadów z modeli PMAXTP oraz działania systemu kanalizacji deszczowej na obszarze Lotniska Chopina. Stwierdzono m.in., że aktualne wysokości (kwantyle) opadów z modelu PMAXTP charakteryzują się przeważnie niższymi wartościami w porównaniu do adekwatnych danych z historycznego modelu Bogdanowicz-Stachý. Wskazano na znaczące różnice w wielkościach opadów z modeli PMAXTP dla stacji pomiarowych Warszawa-Bielany i Świder oddalonych od siebie o ok. 27 km. W wyniku hydrodynamicznych symulacji w modelu SWMM ustalono, że przyjęte modele opadowe mają znaczący wpływ na wartości przepływu wód w badanej zlewni. Uzyskano informacje o występowaniu przeciążeń dla określonych kanałów deszczowych i wylewów na obszarze Lotniska Chopina.
Analiza wybranych regulacji wprowadzonych ustawą o przeciwdziałaniu nieuczciwemu wykorzystywaniu przewagi kontraktowej w obrocie produktami rolnymi i spożywczymi – jakie zmiany w polskim prawie?
Authors:   Katedra Prawa Gospodarczego Publicznego Uniwersytetu Szczecińskiego, Salitra Małgorzata ,   pracownik Departamentu Ochrony Konkurencji w UOKiK
Published: January 2025

Artykuł prezentuje wybrane regulacje zawarte w ustawie z 15 grudnia 2016 r. o przeciwdziałaniu nieuczciwemu wykorzystywaniu przewagi kontraktowej w obrocie produktami rolnymi i spożywczymi przygotowanej przez Ministerstwo Rolnictwa i Rozwoju Wsi. Ustawa dotyczy wprowadzenia pieniężnych kar administracyjnych za nieuczciwe wykorzystywanie przewagi kontraktowej. Postępowanie będzie wszczynał z urzędu Prezes UOKiK, a zawiadomienie dotyczące podejrzenia stosowania tych praktyk będzie mógł zgłosić przedsiębiorca, jeżeli podejrzewa stosowanie takich praktyk wobec siebie. Autorka podejmuje próbę przedstawienia zwięzłego opisu najistotniejszych – w jej ocenie – postanowień zawartych w ww. ustawie. Jednocześnie wskazuje na pewne trudności, z jakimi mogą spotkać się przedsiębiorcy przy ocenie swoich działań pod kątem zgodności z przepisami omawianej ustawy.
Social Impact Bonds: Issues of Identity and Independence for the Voluntary Sector
Authors:   , Soutar Josie
Published: January 2025

This thesis explores Voluntary Sector (VS) engagement with Social Impact Bond (SIB) policy agenda in the UK. SIB’s typically involve three parties: an (social) investor, a public agency and voluntary sector deliverers; and often a fourth party specialist intermediary. SIBs aim to encourage a collaborative approach to public service delivery with these different stakeholders coming together to co-design services that achieve both social change and cashable savings to the state. England has been a pioneer of SIBs which were introduced by the 2010 UK Government during a time when VS organisations faced unprecedented and widespread cuts to their funding. At the beginning of this study, the SIB literature was still relatively limited and emerging, but has grown over recent years. Despite developments in the SIB academic literature, there is a clear gap around the involvement of the VS as SIB delivery partners- a gap which this thesis aims to address. Through the investigation of SIBs as a VS funding mechanism, this study sought to understand issues of identity, distinctiveness and independence for VS organisations in relation to the state and other actors. The thesis takes a novel approach to research methods, contributing to the knowledge of methodological strategies for the study of the VS. The research was conducted using a mixed-method research design combining frame analysis, Q method, focus groups and interviews. Through a new institutionalist approach, data were analysed at micro, meso and macro levels to explore the institutional logics at play in the framing of SIBs at multiple levels so as to understand VS responses, agency and decision-making in relation to SIBs. This thesis provides empirical contributions to knowledge around the VS’s relationship with the state, the evolution of the VS’s role in delivering state social outcomes and VS leaders’ attitudes to increasingly market-based state funding models. The thesis contributes to VS theory by finding that Salamon’s Voluntary Failure Theory (1987) is limited in its application on 21st century VS organisations which are delivering social outcomes on behalf of the state. It concludes that the market-based commissioning processes which give access to state funding in fact continue to embed traditional inequitable power relations between the state and VS organisations.
Centre Stage: Traversing Australian Live Music Careers in Light of the COVID-19 Pandemic
Authors: Ballico Christina
Published: January 2025

Live music performance provides a source of income and opportunities for musicians to develop creative and performance skills as well as engage with peers. The Australian live music sector, however, was shuttered as part of the public health measures enacted during the global COVID-19 pandemic. Drawing on findings from a multi-year national study into the portfolio careers of Australian musicians (2016–2019), this article reports findings related to live music performance and considers them in relation to the sector’s shuttering. It argues for the consideration of the role and nuance of performance as we re-emerge in a post-pandemic world so that the diversity of formats and opportunities are sustained.
Effects of an Online Ukulele Workshop Series on Sense of Community, Social Support, and Arts Engagement in Veterans, Service Members, and Families
Authors: Dhokai Niyati , Baraniecki-Zwil Gwen , McCarthy Glen , Fasick Emily Romig , Chong Lillian , Ambegaonkar Jatin P.
Published: January 2025

The purpose of this study was to examine the effect of arts engagement during the onset of the COVID-19 pandemic via virtual delivery of music workshops for military-connected people. Twenty participants completed an online survey before and after participation that included two validated surveys measuring sense of community and social support, ten questions assessing motivators for participation, and open-ended ethnographic qualitative questions examining intended and fulfilled participation goals. Despite the social distancing challenges of COVID-19, our participants’ sense of community and social support did not decline over time, likely because of their engagement in the workshops. Participants’ achieved goals included learning how to play the ukulele, songs, joining with others and making connections, praising the leaders and community, and feeling that their voice was incorporated in the workshops.
“I Doubt If They Were Unusual”: Race and Place in Helen Creighton’s 1967 African Nova Scotian Recording Project
Authors: Greencorn Chris
Published: January 2025

Helen Creighton (1899–1989) was one of Canada’s foremost folk song collectors and folklorists. Her fieldwork, which spanned the late 1920s to the mid- 1960s, centred on her home province of Nova Scotia. This article critically examines Helen Creighton’s 1967 recording project in African Nova Scotian communities, particularly in the historic settlement of Africville during its notorious displacement by the city government of Halifax. Despite receiving little attention in the half-century since, the 1967 project offers considerable insight into the place of race and racialization in Creighton’s influential conception of Nova Scotian folk culture. I argue that Creighton observed a double standard around the authenticity of the African Nova Scotian songs she collected vis-à-vis those collected in white communities, and that this inequitable treatment was intrinsically connected to the rhetorical and physical displacement of African Nova Scotians that underwrote her project.
Las bodegas cooperativas durante el franquismo: un análisis del diseño institucional
Authors: Medina Albaladejo Francisco José
Published: January 2025

Durante el periodo franquista se produjo la expansión y consolidación del cooperativismo en el sector vitivinícola español. El objetivo principal de este trabajo es determinar el papel del diseño institucional en este proceso. Las bodegas cooperativas crecieron en número e importancia durante el mencionado periodo, pero no funcionaron de forma eficiente. El diseño institucional de estas entidades en un contexto de dictadura presentaba dos problemas fundamentalmente: la profunda heterogeneidad social de los miembros, que derivó en conflictos de intereses y la aparición de comportamientos oportunistas; y el diseño de unas normas no ideadas localmente y de difícil cumplimiento que no pudieron reducir el impacto de las actitudes del free-rider. Las bodegas cooperativas españolas no fueron entidades surgidas de manera espontánea y a nivel local, sino que respondían al impulso dado por el Estado franquista que las financió y controló mediante su integración en las estructuras corporativas del Régimen.
De la utopía a la armonía: la huella del krausismo económico en la primera legislación cooperativa española
Authors: Soler Tormo Francisco Vicente
Published: January 2025

Con la Ilustración, especialmente a partir de las figuras de Kant y Smith, se da paso a una filosofía de la historia optimista. Esto supone entender la historia como una marcha hacia el progreso, transformando el caos en un orden racional y armónico. El destino final es un mundo en el que la tecnología permita satisfacer las necesidades humanas y la población se vea liberada del trabajo alienante. La marcha hacia la civilización no podía ser impuesta, sino movida por la búsqueda del interés individual como impulsor del bienestar colectivo y por la tendencia innata a la asociación libre y a la solidaridad.
Para ello era necesario dotar a la economía de instituciones apropiadas, como las coopera­tivas, que favorecieran los objetivos de eficiencia y equidad, como trataron de impulsar los socialistas utópicos Owen, Saint-Simon o Fourier.
Cooperativismo y economía social y solidaria en el constitucionalismo histórico español
Authors: Jimena Quesada Luis
Published: January 2025

El presente artículo tiene por objeto analizar el impacto evolutivo de los valores constitucionales en el cooperativismo y la economía social y solidaria en España. A tal efecto, se abordan primeramente las coordenadas en las que se desenvolvió el corporativismo en el primer constitucionalismo liberal decimonónico y del primer tercio del siglo XX, para a continuación examinar los elementos que coadyuvaron a instaurar el cooperativismo social y solidario en el contexto de la Constitución republicana de 1931. Seguidamente se somete a escrutinio la tensión dialéctica con la que se enfocó el modelo cooperativo bajo el régimen franquista, para así comprender el marco consensual alcanzado en el movimiento cooperativo en el escenario del régimen constitucional vigente de 1978. Ponen colofón al trabajo unas reflexiones sobre la evolución de nuestro constitucionalismo, en clave multinivel y europeizada, y la paralela actualización del cooperativismo social y solidario.
Orígenes y evolución de las cooperativas de crédito hasta su equiparación como entidades de crédito
Authors: Vañó Vañó Mª José
Published: January 2025

Este artículo examina la evolución histórica y jurídica de las cooperativas de crédito, desde sus orígenes en el siglo XIX hasta su consolidación como entidades de crédito equiparadas a las instituciones financieras convencionales. A través de un análisis detallado, se identifican tres etapas clave en su desarrollo: la distinción inicial de las cooperativas respecto a las sociedades mercantiles y sindicatos; la formalización del cooperativismo de crédito durante el régimen franquista; y finalmente, la equiparación con las entidades de crédito en la España democrática, destacando la Ley 13/1989 que estableció un marco jurídico unificado para estas instituciones. Además, se discute la naturaleza jurídica de las cooperativas de crédito, situándolas como entidades sui generis dentro del derecho cooperativo y financiero, y se evalúan las implicaciones de su evolución normativa en el contexto del sistema financiero español.
Celebração e dificuldades: uma análise comparativa de narrativas homoeróticas adolescentes em “Vinte Bombons de Banana” de Vitor Martins e “A Aventura do Peru de Natal” de Lucas Rocha
Authors: Wąsowicz-Kiryło Piotr
Published: January 2025

This article aims to analyze two Christmas homoerotic stories with male, homosexual adolescent protagonists: ‘Vinte Bombons de Banana’ by Vitor Martins and ‘A Aventura do Peru de Natal’ by Lucas Rocha, both part of the anthology Todas as Cores do Natal (2017). Using comparative and bibliographic methods, the study highlights the different hardships faced by homosexual adolescent boys as portrayed by the authors and examines the problematic aspects of how sexuality is depicted in their plots. It concludes that contemporary Brazilian authors, particularly those writing young adult narratives, tend to focus more on celebrating homosexuality while acknowledging its associated challenges, rather than solely emphasizing the negative aspects of being a homosexual adolescent boy.
Cell crowding induces TRPV4 inhibition and its relocation to plasma membranes, implicating pro-invasive cell volume reduction mechanotransduction pathway
Authors: Bu Xiangning , Ashby Nathanael , Vitali Teresa , Lee Sulgi , Gottumukkala Ananya , Yun Kangsun , Tabbara Sana , Latham Patricia , Teal Christine , Chung Inhee
Published: January 2025

Cell crowding is a common microenvironmental factor that affects various disease processes, but its impact on cell invasiveness into surrounding tissues is not well understood. This study investigates the biomechanical changes induced by cell crowding, focusing on pro-invasive cell volume reduction in ductal carcinoma in situ (DCIS) cells. DCIS is a non-invasive form of breast cancer characterized by abnormal cell growth confined within the breast duct. While DCIS can undergo invasive transition, it is unclear which DCIS cells are predisposed to this transition. We discovered that cell crowding enhanced the invasiveness of high-grade DCIS cells, which experienced significant cell volume reduction compared to hyperplasia-mimicking or normal cells. Mass spectrometry analyses revealed that cell crowding relocated ion channels, including TRPV4, a calcium-permeant ion channel, to the plasma membrane selectively in high-grade DCIS cells but not in less aggressive or normal cells. Cell crowding inhibited TRPV4 activity in high-grade DCIS cells, decreasing intracellular calcium levels and reducing cell volume. This inhibition also triggered the relocation of TRPV4 to the plasma membrane, effectively priming the inactive channel for activation and mitigating the calcium loss caused by crowding-induced inhibition. Analyses of patient-derived breast cancer tissues validated that TRPV4 is selectively associated with the plasma membrane in high-grade DCIS but not in lower-grade DCIS or less aggressive pathologies. The extent of plasma membrane TRPV4 association scaled with cell volume reduction and increased cell invasiveness and motility, suggesting its utility as an active pro-invasive mechanotransduction pathway indicator. Additionally, hyperosmotic conditions and pharmacologic TRPV4 inhibition mimicked the pro-invasive volume reduction observed under cell crowding, while TRPV4 activation reversed this effect by inducing cell volume increase. Silencing the TRPV4 gene via shRNA diminished the mechanotransduction capability of high-grade DCIS cells, as demonstrated by reduced intracellular calcium depletion, attenuated cell volume reduction, and decreased motility. In summary, this study uncovers a previously unrecognized pro-invasive mechanotransduction pathway initiated by cell crowding, which is specific to high-grade DCIS cells, revealing a potential biomarker for identifying DCIS patients at high risk of invasive transition.
Paradoxical dominant negative activity of an immunodeficiency-associated activating PIK3R1 variant
Authors: Tomlinson Patsy R , Knox Rachel G , Perisic Olga , Su Helen , Brierley Gemma V , Williams Roger L , Semple Robert K
Published: January 2025

PIK3R1 encodes three regulatory subunits of class IA phosphoinositide 3-kinase (PI3K), each associating with any of three catalytic subunits, namely p110α, p110β, or p110δ. Constitutional PIK3R1 mutations cause diseases with a genotype-phenotype relationship not yet fully explained: heterozygous loss-of-function mutations cause SHORT syndrome, featuring insulin resistance and short stature attributed to reduced p110α function, while heterozygous activating mutations cause immunodeficiency, attributed to p110δ activation and known as APDS2. Surprisingly, APDS2 patients do not show features of p110α hyperactivation, but do commonly have SHORT syndrome-like features, suggesting p110α hypofunction. We sought to investigate this. In dermal fibroblasts from an APDS2 patient, we found no increased PI3K signalling, with p110δ expression markedly reduced. In preadipocytes, the APDS2 variant was potently dominant negative, associating with Irs1 and Irs2 but failing to heterodimerise with p110α. This attenuation of p110α signalling by a p110δ-activating PIK3R1 variant potentially explains co-incidence of gain-of-function and loss-of-function PIK3R1 phenotypes.
Syngeneic natural killer cell therapy activates dendritic and T cells in metastatic lungs and effectively treats low-burden metastases
Authors: Huang Shih-Wen , Lai Yein-Gei , Liao Hao-Ting , Chang Chin-Ling , Ma Ruo-Yu , Chen Yung-Hsiang , Liou Yae-Huei , Wu Zhen-Qi , Wu Yu-Chen , Liu Ko-Jiunn , Huang Yen-Tsung , Yang Jen-Lung , Dai Ming-Shen , Liao Nan-Shih
Published: January 2025

Natural killer (NK) cells can control metastasis through cytotoxicity and IFN-γ production independently of T cells in experimental metastasis mouse models. The inverse correlation between NK activity and metastasis incidence supports a critical role for NK cells in human metastatic surveillance. However, autologous NK cell therapy has shown limited benefit in treating patients with metastatic solid tumors. Using a spontaneous metastasis mouse model of MHC-I+ breast cancer, we found that transfer of IL-15/IL-12-conditioned syngeneic NK cells after primary tumor resection promoted long-term survival of mice with low metastatic burden and induced a tumor-specific protective T cell response that is essential for the therapeutic effect. Furthermore, NK cell transfer augments activation of conventional dendritic cells (cDCs), Foxp3-CD4+ T cells and stem cell-like CD8+ T cells in metastatic lungs, to which IFN-γ of the transferred NK cells contributes significantly. These results imply direct interactions between transferred NK cells and endogenous cDCs to enhance T cell activation. We conducted an investigator-initiated clinical trial of autologous NK cell therapy in six patients with advanced cancer and observed that the NK cell therapy was safe and showed signs of effectiveness. These findings indicate that autologous NK cell therapy is effective in treating established low burden metastases of MHC-I+ tumor cells by activating the cDC-T cell axis at metastatic sites.
Prabhat Ranjan Sarkar’s Neo-humanism: A Framework for Inclusive and Value-based Education
Authors: Ghosh Subhendu , Shinde Dhiraj , Sarkar Ratan
Published: January 2025

Prabhat Ranjan Sarkar's Neo-Humanism presents a progressive and holistic educational philosophy that aligns with inclusive and value-based education, emphasizing the development of all human faculties, social cohesion, and universal human values. Neo-Humanism challenges conventional educational paradigms by proposing an integrated approach that nurtures both intellect and spirit. This framework focuses on the collective well-being of individuals, integrating education with ethics, morality, and a sense of responsibility towards both humanity and the environment. The Neo-Humanist approach encourages educators to cultivate a learning environment that respects diversity, fosters creativity, and ensures equitable opportunities for all learners, including marginalized and differently abled students. Through the application of Sarkar's principles, education can transcend knowledge transmission and become a transformative tool for societal progress, fostering compassionate, socially aware, and empowered individuals. This paper examines the relevance and applicability of Neo-Humanism in contemporary educational settings, particularly in promoting inclusivity, equity, and universal human values.
Innovative Practices in Large-span Prestressed Concrete Beam Construction for Housing Projects
Authors: Tan Zilong , Gao Yao , Wu Shaojie
Published: January 2025

Large-span prestressed concrete beam is a structural form widely used in modern buildings, and the rationality of its construction technology is directly related to the engineering quality and safety. Article on the analysis of large span prestressed concrete beam construction points, on the basis of new template support system application, steel connection, high performance concrete mix ratio design, intelligent tension system application of key construction technology, and discusses the BIM technology application, prefabricated construction, green construction process optimization and innovation. The results show that the construction technology of large-span prestressed concrete beam is feasible and effective, which can provide a reference for similar projects.
Genetic Variants, Serum 25-Hydroxyvitamin D Levels, and Sarcopenia
Authors: Sha Tingting , Wang Yilun , Zhang Yuqing , Lane Nancy E. , Li Changjun , Wei Jie , Zeng Chao , Lei Guanghua
Published: August 2023

Importance

Vitamin D deficiency is commonly associated with sarcopenia; however, the latest International Clinical Practice Guidelines for Sarcopenia do not recommend vitamin D supplementation for sarcopenia owing to a lack of an apparent therapeutic effect on the indices of sarcopenia among participants with replete vitamin D concentration (ie, 25-hydroxyvitamin D [25(OH)D] level >20 ng/mL) from randomized clinical trials. While there is consensus in all vitamin D guidelines that serum levels of 25(OH)D less than 10 ng/mL should be corrected, approximately 30% of the world population’s 25(OH)D levels range from 10 to 20 ng/mL, and it remains unclear whether such suboptimal levels can maintain optimal health, including sarcopenia risk.

Objective

To investigate the association of serum 25(OH)D level, especially suboptimal levels, with sarcopenia risk.

Design, Setting, and Participants

This genome-wide genetic association study was performed from August 2022 to February 2023 among the 295 489 unrelated European participants from the UK Biobank (2006-2010). Nonlinear and standard mendelian randomization analyses were used to examine the association of serum 25(OH)D concentration with sarcopenia risk.

Exposures

A weighted genetic risk score using 35 unrelated single-nucleotide variants from the UK Biobank and weights from the SUNLIGHT Consortium was selected as an instrumental variable for serum 25(OH)D concentration.

Main Outcomes and Measures

The primary outcome was sarcopenia, and the secondary outcomes consisted of grip strength, appendicular lean mass index, and gait speed.

Results

The final genetic analyses included 295 489 participants (mean [SD] age, 56.3 [8.1] years; 139 216 female [52.9%]). There was an L-shaped association between genetically predicted serum 25(OH)D concentration and sarcopenia risk. The risk of sarcopenia decreased rapidly as 25(OH)D concentration increased until 20 ng/mL and then leveled off. The odds ratio of sarcopenia for serum 25(OH)D level of 10 vs 20 ng/mL was 1.74 (95% CI, 1.17-2.59). Similar patterns were also observed when the association between serum 25(OH)D concentration and risks of each of the sarcopenia indices were evaluated.

Conclusions and Relevance

In this mendelian randomization genetic association study of adults in the UK Biobank, the findings supported a nonlinear association between suboptimal 25(OH)D levels and sarcopenia risk. Randomized clinical trials among participants with suboptimal 25(OH)D levels are required to verify the potential causality.
Resuscitative Endovascular Balloon Occlusion of the Aorta for Nontraumatic Gastrointestinal Hemorrhage in the US
Authors: Ashbrook Matthew , Cheng Vincent , Kohrman Nathan , Schellenberg Morgan , Martin Matthew , Inaba Kenji , Matsushima Kazuhide
Published: August 2023

This cohort study describes the use of and outcomes for resuscitative endovascular balloon occlusion of the aorta for managing nontraumatic gastrointestinal bleeding.
Turbocharging synaptic transmission
Authors: Rothman James E. , Grushin Kirill , Bera Manindra , Pincet Frederic
Published: August 2023

Evidence from biochemistry, genetics, and electron microscopy strongly supports the idea that a ring of Synaptotagmin is central to the clamping and release of synaptic vesicles (SVs) for synchronous neurotransmission. Recent direct measurements in cell‐free systems suggest there are 12 SNAREpins in each ready‐release vesicle, consisting of six peripheral and six central SNAREpins. The six central SNAREpins are directly bound to the Synaptotagmin ring, are directly released by Ca++, and they initially open the fusion pore. The six peripheral SNAREpins are indirectly bound to the ring, each linked to a central SNAREpin by a bridging molecule of Complexin. We suggest that the primary role of peripheral SNAREpins is to provide additional force to ‘turbocharge’ neurotransmitter release, explaining how it can occur much faster than other forms of membrane fusion. The SV protein Synaptophysin forms hexamers that bear two copies of the v‐SNARE VAMP at each vertex, one likely assembling into a peripheral SNAREpin and the other into a central SNAREpin.