bluuebunny/crossref_metadata_2025 huggingface dataset:
Chinese Herbal Extractions for Relieving Radiation Induced Lung Injury: A Systematic Review and Meta‐Analysis
Authors: Deng Bo , Deng Chao , Cheng Zhiqiang
Published: March 2017

Background. Radiation induced lung injury (RILI) is one of the most common and severe side effects of thoracic radiotherapy. In this meta‐analysis, the effects of Chinese herbal extractions (CHE) for preventing and treating RILI are evaluated. Methods. Randomized Controlled Trials (RCTs) from five databases were identified. Studies were evaluated and the relevant data were extracted by two authors independently. Differences were resolved by a third party. Meta‐analysis was conducted using RevMan 5.0. Results. In total, 2734 participants receiving thoracic radiotherapy were included in 28 RCTs, and 16 CHE were evaluated. Meta‐analysis showed that CHE intervention significantly reduced the incidence of acute radiation pneumonitis (RP) and radiation induced pulmonary fibrosis (RIPF). In CHE group, total effective rate and remission rate of RILI patients were significantly higher. Patient’s quality of life (Qol) and clinical symptoms and signs were improved significantly. Inflammatory cytokines decreased, and thymus dependent lymphocytes subgroups were improved. Conclusion. CHE intervention may have clinical effectiveness for relieving RILI and related symptoms and signs and lead to improvement of Qol. However, more double‐blind, multicenter, large‐scale RCTs are needed to support this theory. Trial Registration. PROSPERO International prospective register of systematic reviews has registration number CRD42016043538.
StochasticH∞Control for Discrete-Time Singular Systems with State and Disturbance Dependent Noise
Authors: Zhao Yong , Jiang Xiushan , Zhang Weihai
Published: March 2017

This paper is concerned with the stochasticH∞state feedback control problem for a class of discrete-time singular systems with state and disturbance dependent noise. Two stochastic bounded real lemmas (SBRLs) are proposed via strict linear matrix inequalities (LMIs). Based on the obtained SBRLs, a state feedbackH∞controller is presented, which not only guarantees the resulting closed-loop system to be mean square admissible but also satisfies a prescribedH∞performance level. A numerical example is finally given to illustrate the effectiveness of the proposed theoretical results.
Emergent Minimally Invasive Esophagogastrectomy
Authors: Fabian Thomas , Chiaravalle Dorothy , Martin Jeremiah
Published: March 2017

Introduction. Esophageal perforation in the setting of a malignancy carries a high morbidity and mortality. We describe our management of such a patient using minimally invasive approach.Methods. An 83-year-old female presented with an iatrogenic esophageal perforation during the workup of dysphagia. She was referred for surgical evaluation immediately after the event which occurred in the endoscopy suite. Minimally invasive esophagectomy was chosen to provide definitive treatment for both her malignancy and esophageal perforation.Results. Following an uncomplicated operative course, she was eventually discharged to extended care for rehabilitation and remains alive four years after her resection.Conclusion. Although traditional open techniques are the accepted gold standard of treatment for esophageal perforation, minimally invasive esophagectomy plays an important role in experienced hands and may be offered to such patients.
Evaluation of Subclinical Left Ventricular Systolic Dysfunction in Chronic Asymptomatic Alcoholics by Speckle Tracking Echocardiography
Authors: Kucuk Murathan , Oncel Can Ramazan , Belgi Yıldırım Aytul , Canan Fatih , Kuloglu Mehmet Murat
Published: March 2017

By using two-dimensional speckle tracking echocardiography, we aimed to investigate the structural and functional changes on myocardium in chronic asymptomatic alcoholics without any cardiovascular disease. Forty-one consecutive asymptomatic male alcoholics who were admitted to the outpatient alcoholism unit and 30 age matched healthy male volunteers selected as the control group were enrolled in the study. The study group were investigated by using standard two-dimensional echocardiography and speckle tracking echocardiography. The left ventricular (LV) global longitudinal strain and LV global circumferential strain were significantly lower in alcoholics when compared with control subjects. There was no difference in global radial strain between the two groups. To demonstrate the effect of total life time dose of ethanol (TLDE) on echocardiographic abnormalities, we assessed the correlation analysis. There was a nonsignificant weak correlation between global LV circumferential strain and TLDE (r=0.27,p=0.083). Speckle tracking echocardiography derived left ventricular systolic function was impaired in chronic alcoholic patients when compared with healthy controls.
Prenatal Diagnosis of a 2.5 Mb De Novo 17q24.1q24.2 Deletion Encompassing KPNA2 and PSMD12 Genes in a Fetus with Craniofacial Dysmorphism, Equinovarus Feet, and Syndactyly
Authors: Naud Marie-Emmanuelle , Tosca Lucie , Martinovic Jelena , Saada Julien , Métay Corinne , Drévillon Loïc , Benoit Virginie , Brisset Sophie , Tachdjian Gérard
Published: March 2017

Interstitial 17q24.1 or 17q24.2 deletions were reported after conventional cytogenetic analysis or chromosomal microarray analysis in patients presenting intellectual disability, facial dysmorphism, and/or malformations. We report on a fetus with craniofacial dysmorphism, talipes equinovarus, and syndactyly associated with a de novo 2.5 Mb 17q24.1q24.2 deletion. Among the deleted genes, KPNA2 and PSMD12 are discussed for the correlation with the fetal phenotype. This is the first case of prenatal diagnosis of 17q24.1q24.2 deletion.
Optimal Disturbances Rejection Control for Autonomous Underwater Vehicles in Shallow Water Environment
Authors: Yang Qing , Su Hao , Tang Gong-You , Gao De-Xin
Published: March 2017

To deal with the disturbances of wave and current in the heading control of Autonomous Underwater Vehicles (AUVs), an optimal disturbances rejection control (ODRC) approach for AUVs in shallow water environment is designed to realize this application. Based on the quadratic optimal control theory, the AUVs heading control problem can be expressed as a coupled two‐point boundary value (TPBV) problem. Using a recently developed successive approximation approach, the coupled TPBV problem is transformed into solving a decoupled linear state equation sequence and a linear adjoint equation sequence. By iteratively solving the two equation sequences, the approximate ODRC law is obtained. A Luenberger observer is constructed to estimate wave disturbances. Simulation is provided to demonstrate the effectiveness of the presented approach.
Results from Two Consecutive Studies of Consolidation Therapy after Autologous Transplant for Multiple Myeloma: Thalidomide, Dexamethasone, and Clarithromycin or Lenalidomide, Dexamethasone, and Clarithromycin
Authors: Holmberg Leona A. , Becker Pamela S. , Bensinger William
Published: March 2017

Background: In multiple myeloma (MM), relapse is a problem after autologous hematopoietic stem cell transplantation (ASCT). In the nontransplant setting, thalidomide/dexamethasone/clarithromycin (BLT-D) and lenalidomide/dexamethasone/clarithromycin (BiRd) achieve responses with acceptable toxicity. Both regimens are reasonable objects of study in the post-ASCT setting. Patients and Methods: We report on BLT-D and BiRd given post-ASCT. Studies were conducted consecutively. After recovery from ASCT, therapy was started. All 3 drugs were given for 1 year, and then immunomodulatory drugs alone were given as long as tolerated or until disease progression. Results: For BLT-D, the most common toxicity was peripheral neuropathy (PN). For BiRd, infection, PN, and neutropenia were the most common adverse events. BiRd was associated with a higher frequency of secondary cancers. The median follow-up for BLT-D was 10.2 years (range 8.6-10.7) and for BiRd it was 7.5 years (range 6.4-8.4). After BLT-D, 18 patients (67%) were alive and 10 (37%) were alive without disease progression, and after BiRd, 18 patients (58%) were alive and 10 (32%) were alive without disease progression. Conclusions: BLT-D and BiRd can be given post-ASCT with different toxicity profiles and comparable disease-free and overall survival rates. A randomized study comparing these regimens to single-agent lenalidomide is needed to determine which approach is superior. Key Message: Relapse of MM is a major problem after ASCT. Strategies are needed post-ASCT to improve outcomes. In the nontransplant setting, thalidomide or lenalidomide/dexamethasone/clarithromycin treat MM with acceptable toxicity. We, thus, studied both regimens post- ASCT. They can be given with different toxicity profiles and result in good disease control.
Papulonodular Secondary Syphilis Presenting as Multiple Distinct Cutaneous Lesions in an HIV-Positive Transgender Woman
Authors: Navrazhina Kristina , Cressey Brienne D. , Minkis Kira
Published: March 2017

We present the first reported case of papulonodular secondary syphilis in an HIV-positive transgender female. Syphilis is classified into primary, secondary, latent, and tertiary stages, with secondary syphilis having notably diverse cutaneous manifestations. Our patient presented with diverse lesions throughout her body, all pathologically consistent with papulonodular secondary syphilis. Proper identification of the multiple presentations of syphilis is crucial to early diagnosis and treatment. This report seeks to broaden the scope of dermatological manifestations that arise secondary to papulonodular syphilis in HIV-positive patients.
Dimensions of Quality and Their Increasing Relevance for Visceral Medicine in Germany
Authors: Keßler Wolfram , Heidecke Claus-Dieter
Published: March 2017

Background: ‘Quality in medicine' is a term used in a broad sense. In this work the definition and dimensions of quality in medicine and the implementation of a measurement and reporting system in Germany are discussed. Existing applications are described and possible future effects are pointed out. Methods: The ongoing process of implementing a quality reporting system into the German healthcare system is studied by publicly available legal texts, published reactions of stakeholders and publications of G-BA and IQTIG. Definitions of quality, dimensions of quality and quality measurement in medicine are studied by using textbooks as well as the world wide web and PubMed search. Results: Donabedian‘s ‘dimensions of quality' are fundamental in dealing with quality in medicine. Existing measurement and reporting systems have immanent strengths and weaknesses, as the definition of quality is affected by one‘s point of view. The legislator will have to decide which ‘dimension of quality' is mandatory and how to measure it. Conclusion: Quality has become a control instrument with unforeseeable consequences. A clear definition of the used quality concept is as essential as the use of feasible measurement and reporting systems. The use of routine data could be an interesting option.
Severe Infectious Complications after Endoscopic Ultrasound-Guided Fine Needle Aspiration of Suspected Mediastinal Duplication Cysts: A Case Series
Authors: Valli Piero V. , Gubler Christoph , Bauerfeind Peter
Published: March 2017

Background and Study Aims: The role of cyst cytology to diagnose mediastinal duplication cysts remains controversial. Since endoscopic ultrasound (EUS)-guided fine needle aspiration (FNA) of duplication cysts has been considered as safe so far, there are only a few case reports of infections following FNA. Case Summary: We report a case series of all patients at our institution undergoing EUS evaluation for suspected mediastinal duplication cysts (n = 5) in the last 15 years. The mediastinal lesion in 4 patients did not feature typical EUS features for duplication cysts, wherefore we did perform EUS-guided FNA in order to rule out malignancy. In 3 out of 4 patients, a duplication cyst was confirmed. The fourth lesion turned out to be a sarcoma. All 4 patients developed severe FNA-induced cyst infection causing mediastinitis and the need for surgical debridement. Despite an immediate review of the FNA by the on-site cytopathologist with establishing the diagnosis of a duplication cyst, peri-interventional broad-spectrum antibiotics could not prevent severe infections of the lesions. Conclusions: Given the potentially high rate of infectious complications, we advocate a very restrictive indication for diagnostic FNA in mediastinal masses. Yet, in unclear cases, FNA might be indispensable despite the potential adverse events in order to rule out hypoechogenic, mediastinal malignancy.
Usefulness of Endobronchial Ultrasound in Patients with Human Immunodeficiency Virus Infection and Mediastinal Lymphadenopathy
Authors: Sánchez-Cabral Olivia , Martínez-Mendoza Dina , Fernandez-Bussy Sebastian , Aspuru-García Esmeralda , Rivera-Rosales Rosa , Luna-Rivero César , Martínez-Orozco José Arturo , Reyes-Terán Gustavo
Published: March 2017

Background: There are few published studies about the usefulness of endobronchial ultrasound (EBUS) in patients infected with human immunodeficiency virus (HIV). The clinical spectrum of likely diseases in this population is varied and differs from patients not infected with HIV. Objective: The aim of this study was to measure the usefulness of EBUS-guided transbronchial needle aspiration (EBUS-TBNA) in HIV-infected patients with mediastinal lymphadenopathy. Materials and Methods: We conducted an observational, cross-sectional, retrospective, descriptive study on patients with HIV infection and mediastinal lymphadenopathy who underwent EBUS-TBNA between September 2014 and April 2016. The patients' final diagnosis, regardless of the sample from which it was obtained, was considered the positive gold standard, and the absence of diagnosis was the negative. The study measured diagnostic accuracy of bronchoalveolar lavage (BAL), transbronchial biopsy (TBB), and EBUS-TBNA. Results: A total of 43 procedures were performed; 79.1% (34/43) of the patients were male, and the median age was 35 years (range, 22-66). The overall diagnostic yield including all types of samples was 90.7% (39/43); the yield of BAL was 50% (21), that of TBB 61.9% (26), and that of EBUS-TBNA was 60.5% (26). The combined yield of BAL with TBB was 69.8% (30); the yield of BAL with EBUS-TBNA was 86% (37) and that of TBB with EBUS-TBNA was 88.4% (38). The highest diagnostic accuracy was 97.7% for the combination of TBB and EBUS-TBNA. Conclusions: The most common infectious diagnoses were tuberculosis, with a higher diagnostic accuracy using EBUS-TBNA than BAL. With malignancies, both EBUS-TBNA and TBB were useful. EBUS-TBNA is a minimally invasive diagnostic tool that should be considered in these patients.
Immunoglobulin D Multiple Myeloma Presenting as Spontaneous Fracture
Authors: Al Hadidi Samer , Katato Khalil , Bachuwa Ghassan
Published: March 2017

Immunoglobulin D multiple myeloma is a rare type of multiple myeloma that usually presents as bone pain, fatigue, or weight loss. We report a case of immunoglobulin D multiple myeloma in a 53-year-old Caucasian male patient with previous medical history of anaplastic oligodendroglioma status post-surgical resection who was evaluated for back pain while mowing the lawn. His physical examination showed tenderness over the lower thoracic vertebrae with no sensory or motor impairment. Initial lab investigations showed normocytic anemia and hypercalcemia with low parathyroid hormone. Magnetic resonance imaging of thoracic spine with and without contrast showed acute pathological fracture of the T12 vertebral body with enhancing soft tissue which extended into the left ventral epidural space and left T11–T12 neural foramen. Serum protein electrophoresis showed abnormal protein band in the gamma globulin. Free light chain assay showed serum free kappa which was elevated at 3,090.0 mg/L (reference range 3.3–19.4 mg/L). Immunoglobulin D was elevated at 566.0 mg/dL (reference range <15.3 mg/dL). The patient was successfully treated with standard chemotherapy and autologous peripheral blood stem cell transplant with complete remission 3 years after starting treatment. Advancement in the treatment of immunoglobulin D multiple myeloma urge clinicians to offer their patients new treatment options especially as of the earlier presentation of this subtype of multiple myeloma and the previous reports of worse prognosis.
Unilateral Linear Punctate Palmoplantar Keratoderma: A Case Report
Authors: Kiatsurayanon Chanisa , Rojanamatin Jinda , Sudtikoonaseth Poonawis , Kampirapap Kowit , Wichaidit Mingkwan , Niyonsaba François
Published: March 2017

Punctate palmoplantar keratoderma (PPPK) is a rare entity with an estimated prevalence rate of 1.17/100,000. PPPK usually presents with bilateral asymptomatic, tiny, hyperkeratotic punctate papules and plaques on the palmoplantar surface. Among the PPPK varieties, the linear presentation is much rarer, and so far there have been only 3 case reports. Here, we report the case of a 27-year-old female Thai patient who presented to our outpatient clinic with unilateral asymptomatic linear thickening lesions on her right sole since childhood. There were no similar lesions on other parts of the body. A histopathologic examination revealed epidermal hyperplasia and hyperkeratosis without columns of parakeratosis or cornoid lamella. The other examinations were normal. The clinical and histological contexts were consistent with a diagnosis of unilateral linear PPPK. The patient was treated with topical 10% urea cream and 10% salicylic acid cream twice daily. To the best of our knowledge, this is the first reported case of unilateral linear PPPK in Thailand, and the fourth reported case worldwide.
Superagonistic CD28 Protects against Renal Ischemic Injury by Expansion of Regulatory T-Cell
Authors: Liang Yiran , Li Yan , Kuang Qing , Ding Xiaoqiang , Wei Zheng , Fang Yi
Published: March 2017

Background: Regulatory T (Treg) cells are a highly suppressive subset of CD4+ lymphocytes and have recently been proved to be crucial to suppress the inflammatory responses of ischemic kidney injury. CD28 superagonists (CD28sa) are monoclonal antibodies that preferentially expand Treg cells without a T-cell receptor and a costimulatory signal. This study aims to test the protection and discover the mechanisms of CD28sa treatment against renal ischemia-reperfusion (IR) injury (IRI). Methods: Male C57BL/6N mice were treated with CD28sa via peritoneal injection (0.1 mg) 6 days before the induction of IRI, or with 18-min ischemic precondition (IPC). IRI was induced by bilateral clamping of renal pedicles for 35 min followed by reperfusion. The role of Treg expansion in renal protection conferred by CD28sa treatment was examined using anti-CD25 antibody. Results: CD28sa treatment alone significantly increased the percentage of Treg cells in the spleen (18.10 ± 2.00 vs. 6.64 ± 0.86%, p < 0.01), peripheral blood (16.43 ± 5.94 vs. 2.57 ± 1.09%, p < 0.01), and kidney (2.69 ± 0.90 vs. 0.53 ± 0.14%, p < 0.01) of C57BL/6N mice 6 days after the administration. Mice pretreated with CD28sa or IPC had less renal injury at 24 h after IRI with attenuation of renal tubular damage and lower serum creatinine compared with the mice that underwent renal IRI alone. The number of infiltrating macrophages in the kidney and IFN-γ secreting CD4+ T cells in peripheral blood were diminished in the CD28sa-IR group and the IPC-IR group. The renal protection bestowed by CD28sa or IPC was abolished by anti-CD25 antibody administration. Conclusions: Treg expansion induced by CD28sa ameliorated renal IRI.
Writing Jewish Astronomy in the Early Hellenistic Age: The Enochic Astronomical Book as Aramaic Wisdom and Archival Impulse
Authors: Reed Annette Yoshiko
Published: March 2017

The full publication of 4Q208 and 4Q209 in 2000 has enabled a renaissance of research on the Enochic Astronomical Book, illumining its deep connections with Babylonian scholasticism and spurring debate about the precise channels by which such “scientific” knowledge came to reach Jewish scribes. This article asks whether attention to Aramaic manuscripts related to the Astronomical Book might also reveal something about Jewish scribal pedagogy and literary production in the early Hellenistic age, particularly prior to the Maccabean Revolt. Engaging recent studies from Classics and the History of Science concerning astronomy, pedagogy, and the place of scribes and books in the cultural politics of the third century bce, it uses the test-case of the Astronomical Book to explore the potential significance of Aramaic sources for charting changes within Jewish literary cultures at the advent of Macedonian rule in the Near East.
Thucydides on Aetiology and Methodology and Some Links with the Philosophy of Heraclitus
Authors: Parmeggiani Giovanni
Published: March 2017

An analysis of Thucydides’ most famous statements on the origins of the war between Athens and Sparta (1.23.4-6) and on the methodology of research of the facts (1.22.2. Cf. 1.20-21) shows a philosophical approach to history and historical research. A critically assessed comparison with some of Heraclitus of Ephesus’ statements also suggests that Thucydides’ own knowledge of early ancient philosophy helped him to shape his view on fundamental issues of historical research.

Thucydides appears to have introduced himself in a similar way as one might expect a philosopher would have done. Besides the rhetoric of self-presentation and self-definition, Thucydides was indeed a philosopher: he conceived his own political science as a hiddensophiawhich showed the invisible forces that, by reciprocal interaction, shaped historical development.
One new species of a new genus, Neoaxius gen. nov., in a new family, Neoaxiidae fam. nov., from the Gulf of Nicoya, Costa Rica (Decapoda, Axioidea)
Authors: Sakai K.
Published: March 2017

Currently, the superfamily Axioidea Huxley, 1879 includes nine families (Sakai, 2011). However, recent examination of material from the Gulf of Nicoya, Costa Rica, Pacific side, presented the occurrence of a new species, Neoaxius nicoyaensis gen. et sp. nov. The deviant morphology of the genital organs of this new species can nowhere be observed in any of the known genera of the families included in the Axioidea. This necessitated the author to establish a new family, Neoaxiidae fam. nov., based on the new genus Neoaxius gen. nov. The new family is safely included in the Axioidea as a tenth member of that superfamily.
What drives non-native amphipod distributions in the River Thames? The role of habitat and human activity on species abundance
Authors: Knight Clarke A. , Hughes Jocelyne M. R. , Johns Tim
Published: March 2017

Increasing colonization of non-native amphipod species in the River Thames, United Kingdom, has altered aquatic ecology and called existing management practices into question. We studied the distribution patterns of recent non-native (Dikerogammarus haemobaphes (Eichwald, 1841)), established non-native (Crangonyx pseudogracilis (Bousfield, 1958)), and native amphipod (Gammarus pulex (Linnaeus, 1758)) species, as well as habitat and human influences across 84 sites in the upper Thames catchment. Our findings showed widespread distribution and density of G. pulex relative to D. haemobaphes, suggesting that the full impact of the current spread has yet to be felt since its 2012 introduction. Different habitat utilization patterns are explained through habitat partitioning: both D. haemobaphes and C. pseudogracilis occupied vegetative habitats, not pebble/gravel habitats where the native G. pulex was most often found. The association between D. haemobaphes and boating presence implies that effective biosecurity would be best focused on boat traffic in the Thames and Cherwell rivers.
The Management of Third-party Amicus Participation before International Criminal Tribunals: Juggling Efficiency and Legitimacy
Authors: Kent Avidan , Trinidad Jamie
Published: March 2017

Our article examines the practice of third-party amicus participation before international criminal tribunals (icts) and considers its impact on the efficiency and legitimacy of the international criminal process. Our review focuses on the provenance of third-party interventions, their nature and their impact (if any) on the reasoning of the ict in a given case. We note that a significant proportion of the amicus submissions are from western non-governmental organizations and individuals, rather than from the communities most directly affected by the work of icts. We consider the implications of this finding in the context of the well-documented ‘image problems’ that plague icts. We find that icts tend to manage the participation of third-party amici fairly judiciously, and conclude with some suggestions regarding how the engagement between icts and amici could be improved to enhance both the efficiency and the legitimacy of international criminal proceedings.
Weaving Relationships
Authors: Gregersen Malin
Published: March 2017

Swedish missionary Ingeborg Wikander (1882–1941) arrived in China in 1916 and worked for the Young Women’s Christian Association (YWCA) in Changsha between 1917 and 1927. During her first years in China, in the process of becoming established in the new country, Wikander moved within several transnational missionary contexts, and she established relationships and networks crucial for her future work. Through the personal example of a Swedish YWCA secretary, this article draws attention to the building of personal relationships within the larger transnational missionary communities of China of the early 20th century. It discusses how such relationships could be interpreted in gendered, national and denominational terms and show how the local, the national and the transnational were entangled in everyday encounters and experiences of individual mission workers like Ingeborg Wikander.
Introduction
Authors: Gewurtz Margo S. , Jalagin Seija
Published: March 2017

Mission history is in multiple ways transnational: it involves ongoing activities across national borders by non-government actors. Despite being sent by national mission societies, missionaries’ lived experiences involved a type of Christian internationalism with contacts, friendships and professional relationships with a variety of foreigners and missionaries from other countries and denominations. Transnationalism, defined as a perspective rather than a theory or methodology, seems well suited for small-scale and local cases rather than the larger ambitions of global history with which it is often confused. The concept of the transnational space invites comparative work on single missions and missionaries that combines the local and the transnational. It enables us to see similarities without losing appreciation of the explanatory power of cultural specificities. Ours is a project to complicate the relation between metropole and colony and our contributors pay attention to ‘national’ and ‘non-national’ at the same time.
Lacan and Beckett
Authors: Chattopadhyay Arka
Published: March 2017

Building on the dialectical tension between neuro-cognitivism and Lacanian psychoanalysis, this article approaches the Beckettian text to localize acts of writing that take place between psychoanalysis and literature. In opposition to the cognitivist model of neuronal relationality, it uses the Lacanian logic of Real non-relation as an inroad into Beckett to explore the material frontier of Beckettian writing where relational meaning reaches its limit. At this limit, we are left with a complex writing between speech and inscription that makes the body of the signifier write against its sense.
Redescription of immature stages of central European fireflies, Part 1: Lampyris noctiluca (Linnaeus, 1758) larva, pupa and notes on its biology (Coleoptera: Lampyridae: Lampyrinae)
Authors: NOVÁK MARTIN
Published: March 2017

The mature larva of Lampyris noctiluca (Linnaeus, 1758) is redescribed and illustrated in detail, including scanning electron microscope images. Male and female pupae are briefly described, including notes on behaviour as well as light production of the immature stages. Observed structures, life cycle and behaviour of larvae and pupae are discussed.
Impact of Assimilating Underwater Glider Data on Hurricane Gonzalo (2014) Forecasts
Authors: Dong Jili , Domingues Ricardo , Goni Gustavo , Halliwell George , Kim Hyun-Sook , Lee Sang-Ki , Mehari Michael , Bringas Francis , Morell Julio , Pomales Luis
Published: March 2017

The initialization of ocean conditions is essential to coupled tropical cyclone (TC) forecasts. This study investigates the impact of ocean observation assimilation, particularly underwater glider data, on high-resolution coupled TC forecasts. Using the coupled Hurricane Weather Research and Forecasting (HWRF) Model–Hybrid Coordinate Ocean Model (HYCOM) system, numerical experiments are performed by assimilating underwater glider observations alone and with other standard ocean observations for the forecast of Hurricane Gonzalo (2014). The glider observations are able to provide valuable information on subsurface ocean thermal and saline structure, even with their limited spatial coverage along the storm track and the relatively small amount of data assimilated. Through the assimilation of underwater glider observations, the prestorm thermal and saline structures of initial upper-ocean conditions are significantly improved near the location of glider observations, though the impact is localized because of the limited coverage of glider data. The ocean initial conditions are best represented when both the standard ocean observations and the underwater glider data are assimilated together. The barrier layer and the associated sharp density gradient in the upper ocean are successfully represented in the ocean initial conditions only with the use of underwater glider observations. The upper-ocean temperature and salinity forecasts in the first 48 h are improved by assimilating both underwater glider and standard ocean observations. The assimilation of glider observations alone does not make a large impact on the intensity forecast due to their limited coverage along the storm track. The 126-h intensity forecast of Hurricane Gonzalo is improved moderately through assimilating both underwater glider data and standard ocean observations.
Free vibration of anisotropic single-walled carbon nanotube based on couple stress theory for different chirality
Authors: Tadi Beni Yaghoub , Mehralian Fahimeh , Karimi Zeverdejani Mehran
Published: March 2017

In the present work, using the couple stress theory, a new model is provided for vibrating behavior of anisotropic carbon nanotubes. Carbon nanotubes have many applications, and careful analysis of their behavior is important. So far, using the isotropic models, several studies have been conducted on carbon nanotube vibration. According to the arrangement of carbon atoms on the nanotube walls, their properties will be different in various directions. Therefore, the behavior of carbon nanotubes must be considered as anisotropic materials. In this article, initially, using the Hamilton's principle, motion equations, and boundary conditions of carbon nanotubes are extracted based on couple stress theory. Afterwards, the equations are solved using the analytical solution method. In the results section, the effect of different parameters, particularly the anisotropic effect, on the carbon nanotube natural frequency is investigated.
Arthroscopic Versus Open Latarjet in the Treatment of Recurrent Anterior Shoulder Dislocation With Marked Glenoid Bone Loss: A Prospective Comparative Study
Authors: Zhu Yiming , Jiang Chunyan , Song Guanyang
Published: March 2017

Background:

Very few studies have compared open Latarjet versus arthroscopic Latarjet procedures.

Purpose:

To compare the clinical and computed tomographic outcomes between open and arthroscopic Latarjet procedures.

Study Design:

Cohort study; Level of evidence, 3.

Methods:

A prospective, comparative study was performed. The open Latarjet group included 44 patients, and the arthroscopic Latarjet group included 46 patients. All patients had more than 2 years of clinical follow-up (range of motion, American Shoulder and Elbow Surgeons [ASES] score, Constant-Murley score, and Rowe score). The position of the transferred coracoid, the screw orientation, and graft resorption were evaluated on computed tomography (CT) scan.

Results:

The surgery time for the open group was significantly shorter than that for the arthroscopic group ( P = .003). No recurrent dislocation occurred in either group. The apprehension test was negative in all patients in both groups. At the final follow-up, no significant difference was detected between the open group and the arthroscopic group regarding any of the clinical outcome measurements. The transferred coracoid graft was level with the glenoid in all patients in both groups. The open group had better position in the superior-inferior direction compared with the arthroscopic group ( P < .001). No significant difference was found in screw orientation between the 2 groups ( P = .102). At 1 year after surgery, patients in the arthroscopic group had significantly less resorption compared with patients in the open group ( P = .044).

Conclusion:

Both procedures are effective for the treatment of recurrent anterior shoulder dislocation with marked glenoid bone loss. The open group had better position in the superior-inferior direction compared with the arthroscopic group. At 1 year after surgery, patients in the arthroscopic Latarjet group showed notably less graft resorption compared with patients in the open Latarjet group.
Systematic Review of Outcomes Reporting in Professional Baseball: A Call for Increased Validation and Consistency
Authors: van der List Jelle P. , Camp Christopher L. , Sinatro Alec L. , Dines Joshua S. , Pearle Andrew D.
Published: March 2017

Background:

Historically, treatment efficacy of professional baseball injuries has been determined by assessing the return-to-play (RTP) rate or using patient-reported functional outcomes scores; however, these methods may not be sensitive and specific enough for elite athletes. As a consequence, performance-based statistics are increasingly being reported in the medical literature.

Purpose:

To (1) assess how treatment efficacy is currently reported in professional baseball players; (2) examine the variability in the reporting of these measures in terms of frequency, length of time followed, and units of measure; and (3) identify any attempts to validate these performance-based statistics.

Study Design:

Systematic review.

Methods:

All studies reporting treatment efficacy in professional baseball in PubMed, Embase, and Cochrane were identified. Data collected included frequency and method of reporting: RTP, functional outcomes, and performance-based statistics.

Results:

Fifty-four studies met all inclusion criteria. Of these, 51 (94%) reported RTP, 12 (22%) utilized functional outcomes, and 18 (33%) provided baseball-specific performance-based statistics to assess treatment efficacy. Great variability was seen in how follow-up was defined (games, seasons, months), duration of follow-up, and which performance-based statistics were utilized. None of the studies validated these performance-based statistics, determined minimal time of follow-up needed, or assessed the baseline variability in these statistics among noninjured players.

Conclusion:

Most studies reported RTP to determine treatment efficacy, but significant variability was seen in how players were followed. Similarly, great variability was noted in the type and number of performance-based statistics utilized. Additional studies are necessary to validate these measures and determine the appropriate length of time that they should be followed.

Clinical Relevance:

This study provides a clear overview of the current methods that are used to determine treatment efficacy in professional baseball players.
Tumor rim cells: From resistance to vascular targeting agents to complete tumor ablation
Authors: Seidi Khaled , Jahanban-Esfahlan Rana , Zarghami Nosratollah
Published: March 2017

Current vascular targeting strategies pursue two main goals: anti-angiogenesis agents aim to halt sprouting and the formation of new blood vessels, while vascular disrupting agents along with coaguligands seek to compromise blood circulation in the vessels. The ultimate goal of such therapies is to deprive tumor cells out of oxygen and nutrients long enough to succumb cancer cells to death. Most of vascular targeting agents presented promising therapeutic potential, but the final goal which is cure is rarely achieved. Nevertheless, in both preclinical and clinical settings, tumors tend to grow back, featuring a highly invasive, metastatic, and extremely resistant form. This review highlights the critical significance of tumor rim cells as the main factor, determining therapy success with vascular targeting agents. We present an overview of different single and combination treatments with vascular targeting agents that enable efficient targeting of tumor rim cells and long-lasting tumor cure. Understanding the nature of tumor rim cells, how they establish, how they manage to survive of vascular targeting agents, and how they contribute in tumor refractoriness, may open new avenues to the development of beneficial strategies, capable to eliminate residual rim cells, and enable tumor ablation once and forever.
Effect of EBI3 on radiation-induced immunosuppression of cervical cancer HeLa cells by regulating Treg cells through PD-1/PD-L1 pathway
Authors: Zhang Song-An , Niyazi Hu-Er-Xi-Dan , Hong Wen , Tuluwengjiang Gu-Li-Xian , Zhang Lei , Zhang Yang , Su Wei-Peng , Bao Yong-Xing
Published: March 2017

This study aimed to investigate the effect of EBI3 on radiation-induced immunosuppression of cervical cancer HeLa cells by regulating Treg cells through PD-1/PD-L1 signaling pathway. A total of 43 adult female Wistar rats were selected and injected with HeLa cells in the caudal vein to construct a rat model of cervical cancer. All model rats were randomly divided into the radiotherapy group ( n = 31) and the control group ( n = 12). The immunophenotype of Treg cells was detected by the flow cytometry. The protein expressions of EBI3, PD-1, and PD-L1 in cervical cancer tissues were tested by the streptavidin–peroxidase method. HeLa cells in the logarithmic growth phase were divided into four groups: the blank, the negative control group, the EBI3 mimics group, and the EBI3 inhibitors group. Western blotting was used to detect PD-1 and PD-L1 protein expressions. MTT assay was performed to measure the proliferation of Treg cells. Flow cytometry was used to detect cell cycle and apoptosis, and CD4+/CD8+ T cell ratio in each group. Compared with before and 1 week after radiotherapy, the percentages of CD4+T cells and CD8+T cells were significantly decreased in the radiotherapy group at 1 month after radiotherapy. Furthermore, down-regulation of EBI3 and up-regulation of PD-1 and PD-L1 were observed in cervical cancer tissues at 1 month after radiotherapy. In comparison to the blank and negative control groups, increased expression of EBI3 and decreased expressions of PD-1 and PD-L1 were found in the EBI3 mimics group. However, the EBI3 inhibitors group had a lower expression of EBI3 and higher expressions of PD-1 and PD-L1 than those in the blank and negative control groups. The EBI3 mimics group showed an increase in the optical density value (0.43 ± 0.05), while a decrease in the optical density value (0.31 ± 0.02) was found in the EBI3 inhibitors group. Moreover, compared with the blank and negative control groups, the apoptosis rates of Treg/CD4+T/CD8+T cells were decreased in the EBI3 mimics group, but the EBI3 inhibitors group exhibited an increase in apoptosis rate. In conclusion, over-expression of EBI3 could reduce the apoptosis of Treg/CD4+T/CD8+T cells and prevent radiation-induced immunosuppression of cervical cancer HeLa cells by inhibiting the activation of PD-1/PD-L1 signaling pathway.
Vapor-grown carbon nanofiber/poly(ethylene-co-vinyl acetate) composites with electrical-active two-way shape memory behavior
Authors: Qian Chen , Zhu Yaofeng , Dong Yubing , Fu Yaqin
Published: March 2017

Vapor-grown carbon nanofibers were filled into poly(ethylene-co-vinyl acetate) through solution mixing to achieve electrical-active two-way shape memory. The vapor-grown carbon nanofiber/poly(ethylene-co-vinyl acetate) nanocomposites were systematically and explicitly investigated through combined analytical techniques. Experimental results showed an increase in crystallization temperature ( Tc) and a decrease in melting temperature ( Tm) as the vapor-grown carbon nanofiber concentration in the nanocomposites increased. This result indicates that carbon nanofibers can act as nucleating agents during crystallization but may hinder the formation of thermodynamically stable crystals. The nanocomposites had a higher modulus but a lower strength than pure poly(ethylene-co-vinyl acetate). In two-way shape memory testing, a decrease in reversible strain and shape recovery occurred in the nanocomposites. Nevertheless, obvious two-way shape switching was observed in all samples during cyclic heating and cooling. The nanocomposite with 15% vapor-grown carbon nanofibers could be electrically heated rapidly and uniformly because of the high conductivity of vapor-grown carbon nanofibers and their uniform distribution in the matrix. Finally, the electrical-active two-way shape memory effect was achieved. This work contributes to the design of electrical-active two-way shape memory polymers in device applications for advanced functions.
Change propagation prediction: A formal model for two-dimensional geometrical models of products
Authors: Masmoudi Mahmoud , Leclaire Patrice , Zolghadri Marc , Haddar Mohamed
Published: March 2017

A product is redesigned by integrating structural or functional modifications to satisfy new needs or requirements. Iterations are also necessary to fine-tune product definition during the initial design process. In both cases, engineering changes are the means by which the product evolves. However, changes are propagated from component to components and from function to functions, leading to nonvalue development activities with extra costs and delays. These engineering changes may have harmful impacts on industrialization and manufacturing; they can drastically hinder efforts to ensure faster time-to-market. Research works currently seek to model, predict, analyze, and assess the impacts of engineering changes and their propagations. This article focuses on changes in a two-dimensional geometrical product model and proposes a new change prediction approach based on two steps. First, the dependencies between the parameters of structural components are identified through experiments. These dependencies are characterized qualitatively, quantitatively, and by formal equations. The changes are then propagated through the network of dependencies, and their consequences are computed. A geometric two-dimensional model of a bicycle is used to illustrate the approach. The results are discussed, and the main contributions of the approach are highlighted while further research paths are presented at the end of this article.
A perfect umma? How ethnicity shapes the organization and operation of Dagestan's jihadist groups
Authors: Souleimanov Emil A
Published: March 2017

Drawing on unique interviews with former jihadists from Russia's autonomous republic of Dagestan, this article is the first to examine the impact of ethnicity on jihadist groups' methods of organization and operations, primarily in terms of their target selection, local support, and recruitment and leadership policies. It distinguishes between largely monoethnic rural jamaats—or jihadist groups—and multiethnic urban jamaats, pointing to the contested nature of ethnicity, particularly in the latter group. It examines the steps taken by the leadership of urban jamaats to overcome ethnic cleavages and avoid interethnic tension both within the jihadists' ranks and with regard to the local population. The article illustrates that, as a divisive phenomenon in multiethnic urban jamaats, ethnic identity has been deliberately downplayed by the leadership of these groups at the expense of strengthening supra-ethnic Salafi-jihadist identity. The article also highlights the significance of ethnic identity in jihadist groups, in spite of it being contradictory to Salafi-jihadist doctrine.
Improving health-care delivery in low-resource settings with nanotechnology
Authors: Abbas James J , Smith Barbara , Poluta Mladen , Velazquez-Berumen Adriana
Published: March 2017

In the two decades after 1990, the rates of child and maternal mortality dropped by over 40% and 47%, respectively. Despite these improvements, which are in part due to increased access to medical technologies, profound health disparities exist. In 2015, a child born in a developing region is nearly eight times as likely to die before the age of 5 than one born in a developed region and developing regions accounted for nearly 99% of the maternal deaths. Recent developments in nanotechnology, however, have great potential to ameliorate these and other health disparities by providing new cost-effective solutions for diagnosis or treatment of a variety of medical conditions. Affordability is only one of the several challenges that will need to be met to translate new ideas into a medical product that addresses a global health need. This article aims to describe some of the other challenges that will be faced by nanotechnologists who seek to make an impact in low-resource settings across the globe.
Geomimicry: harnessing the antibacterial action of clays
Authors: Williams Lynda B.
Published: March 2017

A decade of research on clays that kill human pathogens, including antibiotic-resistant strains such as methicillin-resistant S. aureus (MRSA), has documented their common characteristics. Worldwide, ∼5% of clays tested to date are antibacterial when hydrated. Most antibacterial clays are from hydrothermally altered volcanics, where volcanogenic fluids produce minerals containing reduced metals. Ferruginous illite-smectite (I-S) is the most common clay mineral, although kaolins dominate some samples. Antibacterial clay mineral assemblages may contain other reduced Fe minerals (e.g. pyrite) that drive production of reactive oxygen species (H2O2,•OH,•O2−) and cause damage to cell membranes and intracellular proteins. Ion exchange can also cause loss of bacterial membrane-bound Ca2+, Mg2+and PO43–.

Critically important is the role of clays in buffering the hydration water pH to conditions where Al and Fe are soluble. A nanometric particle size (<200 nm) is characteristic of antibacterial clays and may be a feature that promotes dissolution. Clay interlayers or the lumen of tubular clays may absorb reduced transition metals, protecting them from oxidation. When the clays are mixed with deionized water for medicinal applications, these metals are released and oxidized.

Different antibacterial clays exhibit different modes of action. The minerals may be a source of toxins, or by adsorption may deprive bacteria of essential nutrients. In the field, the pH and Eh (oxidation state) of the hydrated clay may help to identify potential antibacterial clays. If the pH is circum-neutral, toxic metals are not soluble. However, at pH < 5 or >9 many metals are soluble and the oxidation of transition metals increases the Eh of the suspension to >400 mV, leading to bacterial oxidation.

Understanding the antibacterial mechanism of natural clay may lead to design of new treatments for antibiotic-resistant bacteria, with potential applications in wound dressings, medical implants ( joint replacements, catheters), animal feed stocks, agricultural pathogens, and production of antibacterial building materials. This research exemplifies how ‘geomimicry’ (copying geochemical processes) may open new frontiers in science.