bluuebunny/crossref_metadata_2025 huggingface dataset:
Barriers in adequacy goals in peritoneal dialysis:evaluation of a cohort with negative selection bias
Authors: Marassi André Luis , Rosa Herculano Maria Aparecida , Ghetti Fabiana , Senra de Souza Sodré Luciana , Schreider Alyne , Silva Fernandes Neimar , Gianotti Franco Marcia Regina , Silva Fernandes Natália Maria
Published: December 2024

Our study aimed to evaluate PD patients by tracing a sociodemographic profile and jointly evaluating the clinical and laboratory parameters of dialysis adequacy, as well as outcomes. A prospective cohort study in the Juiz de Fora Federal University Hospital dialysis unit in Brazil between July 2021 and July 2022. The sociodemographic, clinical, laboratory data and adherence were assessed. The Short Assessment of Health Literacy for Portuguese-speaking Adults score, a score of perception of social support, a tool for evaluating QoL (SF-12), and Malnutrition Inflammation Score (MIS) were performed. The primary outcomes were death and QoL, whereas technique failure and hospitalization were secondary. Fifty-six patients in automated peritoneal dialysis modality were evaluated (73.2% prevalent and 26.8% incident). The majority were women (61.2 ± 13.9 years old), white, illiterate and with low income. All patients were hypertensive, one-third had diabetes mellitus (DM) and 76.8% were compliant. The definition of goals was the patient stayed within the normal range within 80% of the following time. The adequacy goals of blood pressure (30.4%) and phosphorus (28.6%) were the most difficult to achieve. Among the primary outcomes, the physical component of the SF-12 was negatively associated with higher MIS, and the mental component of the SF-12 was negatively correlated with higher age. There was no significant difference in death as an outcome. The factors that were associated with the achievement of goals were age, previous nephrological follow-up, dementia, DM, and adherence.
Unravelling antisymmetric exchange in a coordination polymer made of copper chloride and triazole
Authors: Shiozawa Hidetsugu , Siddiqui Shiraz Ahmed , Prado-Roller Alexander , Eisterer Michael
Published: December 2024

The present work reports the synthesis, structure, and magnetic properties of a one-dimensional coordination polymer made of copper(II) chloride and 1,2,4- triazole. The coordination polymer is synthesized in hydrochloric acid at room temperature. The structure determination by single crystal X-ray diffraction reveals an array of copper atoms bridged via two chlorine and a triazole. Magnetisation data show no hysteresis at temperatures down to 2 K, but suggest antisymmetric exchange and antiferromagnetic coupling between the neighbouring spins of Cu(II) ions. This work gives impetus for the synthesis of large crystals of coordination polymers based on which magnetic properties can be studied in depth.
Autoparty: Machine Learning-Guided Visual Inspection of Molecular Docking Results
Authors: Shub Laura , Korczynska Magdalena , Muir Duncan F. , Lin Fang-Yu , Mathiowetz Alan M. , Keiser Michael J.
Published: December 2024

Human inspection of potential drug compounds is crucial in the virtual drug screening pipeline. However, there is a pressing need to accelerate this process, as the number of molecules humans can realistically examine is extremely limited relative to the scale of virtual screens. Furthermore, computational medicinal chemists can evaluate different poses inconsistently, and there is no standard way of recording annotations. We propose Autoparty, a containerized tool to address these challenges. Autoparty leverages on-premises active learning for drug discovery to facilitate human-in-the-loop training of models that extrapolate human intuition. We leverage multiple uncertainty quantification metrics to query the user with informative examples for model training, limiting the number of human expert training labels. The collected annotations populate a persistent and exportable local database for broad downstream uses. Incorporating Autoparty doubled the hit rate among 193 experimentally tested compounds in a real-world case study.
Testing the acceleration of the flavin-N(5)-hydroperoxide formation by O2 binding in monooxygenase EncM by QM/MM MD simulations
Authors: Odintsov Konstantin , Domratcheva Tatiana
Published: December 2024

In monooxygenase EncM, the reduced flavin cofactor binds O2 to form an uncommon oxygenating species – flavin-N(5)-oxide. Here we present the results of QM/MM MD demonstrating that the regioselective O2 activation is driven by the O2 binding pose in EncM. We report the free-energy of the superoxide radical binding to the flavin N(5) and C(4a) positions and link these energies and distances of O2 binding returned by the QM/MM MD simulations.
A single outer-sphere amino-acid substitution turns on the NO reactivity of a hemerythrin-like protein
Authors: ALBERT THERESE , PENCE NATASHA , ZHONG FANGFANG , PLETNEVA EKATERINA , MOENNE-LOCCOZ PIERRE
Published: December 2024

Mycobacterial hemerythrin-like proteins (HLPs) are important for the survival of pathogens in macrophages. Their molecular mechanisms of function remain poorly defined but recent studies point to their possible role in nitric oxide (NO) scavenging. Unlike any nonheme diiron protein studied so far, the diferric HLP from Mycobacterium kansasii (Mka-HLP) reacts with NO in a multistep fashion to consume four NO molecules per diiron center. HLPs are largely conserved across mycobacteria and we argued that comparative studies of distant orthologs may illuminate the role of the protein scaffold in this reactivity and yield intermediates with properties more favorable for detailed spectroscopic characterization. Herein, we show that HLP from Azotobacter vinelandii (Avi-HLP) requires a single T47F point mutation in the outer sphere of its diferric center to adopt a bridging mu-oxo diferric structure alike that of Mka-HLP that makes it reactive toward NO. Radical combination of NO with the mu-oxo bridge yields nitrite and a mixed valent Fe(III)Fe(II) cluster that further react with NO to produce a stable magnetically coupled Fe(III){FeNO}7 cluster. We report characterization of this stable cluster by electronic absorption, EPR, FTIR and resonance Raman spectroscopies and suggest ways Phe 46 (Mka numbering) might control the Fe(III) reduction potential and the NO reactivity of HLPs.
Using Measurement-Informed Inventory to Assess Emissions in the Denver-Julesburg Basin
Authors: Santos Arthur , Mollel Winrose , Duggan Jerry , Hodshire Anna , Vora Prajay , Zimmerle Daniel
Published: December 2024

Aerial surveys, while effective in detecting emissions from upset conditions, face challenges in fully capturing CH4 emissions due to their temporal limitations, variability in measurements, and detection thresholds. Conversely, annual inventories submitted by operators likely don’t include emissions from failure events. This study introduces a novel methodology that utilizes the Mechanistic Air Emissions Simulator (MAES) to integrate two highly variable estimation methods: inventory and aerial methods. The proposed methodology identifies and characterizes failure events with site-specific information, thereby enhancing the accuracy of inventory programs through the so-called measurement-informed inventories (MIIs). Furthermore, it emphasizes the importance of carefully comparing instantaneous emission measurements from aerial surveys with annual average emissions reported in inventories, as they have distinct timeframes. Colorado State University (CSU) collaborated with the Colorado Department of Public Health and Environment (CDPHE) to utilize this approach to enhance reported emissions from the upstream sector in Colorado Denver-Julesburg (DJ) basin. This initiative is part of the state’s efforts to reduce emissions under the Upstream greenhouse gas (GHG) Intensity Program. The goal was to incorporate measured emissions from failure events conducted by Carbon Mapper (CM) in the simulations to derive a multiplier that rectifies for potential omissions of emissions from abnormal conditions within the oil and gas (O&G) sector. To simplify the simulation process, prototypical sites were defined in conjunction with operators and are used to represent groups of O&G facilities in the basin with similar configuration. The outcomes of this work indicate that inventories are likely underestimating total emissions, as an additional 16.4% of total emissions from abnormal events is estimated for the basin.
Investigating whether alcohol is transformed to norepinephrine or dopamine in the mouse brain: preliminary findings
Authors: Wlaź Piotr , Fitzgerald Paul J. , Żmudzki Paweł , Socala Katarzyna
Published: December 2024

A number of studies in rodents have shown various effects of alcohol (ethanol) administration on the catecholaminergic neurotransmitters, norepinephrine (NE) and dopamine (DA). These studies suggest that presentation of alcohol to mice or rats can alter brain levels of NE and DA, in various subregions. Three previous publications (Fitzgerald 2012, 2020, 2022) have presented the hypothesis that there may be an unidentified pathway in rodents, and other organisms, that actually transforms ethanol to NE or DA. Here, this paper investigates the hypothesis in male CD-1 mice. Experimental mice were systemically injected with an intoxicating dose of stable isotope-labeled carbon 13 (C13) ethanol (ethanol-1-13C, 20% v/v, 1.5 g/kg, i.p.), and brain samples (hippocampus and brainstem) were collected two hours post-injection. Two other groups of mice received normal unlabeled carbon 12 (C12) ethanol or a water (Control) injection, respectively. Although we had difficulty detecting the two neurotransmitters (especially C13 NE) due to their very low concentrations, high resolution mass spectrometry analysis suggests that C12 ethanol selectively boosted hippocampal C12 NE, and C13 ethanol likewise boosted hippocampal C13 NE. We did not observe effects on DA. These data provide preliminary information on whether there is a novel biosynthetic pathway in mice that converts alcohol to catecholamines in select brain regions, where the ethanol molecule would presumably lead to formation of the ethanolamine side chain of NE. There are, however, alternative interpretations of these findings, including that acute alcohol administration modulates catecholamine release, reuptake, metabolism, or canonical biosynthesis.
Evaluation of Membrane Mimetics for the Native Ion Mobility – Mass Spectrometry Analysis of Membrane Proteins
Authors: Levesque Iliana , Parson Kristine , Fantin Sarah , Ruotolo Brandon
Published: December 2024

Membrane protein (MP) structures and functions are intricately linked to their surrounding membrane environments and their respective lipid compositions in addition to influences exerted by unique membrane microdomains (i.e., lipid rafts). Owing to the complexity of their native environments, MPs pose significant challenges to structural biology due to their in-trinsic hydrophobic nature rendering them incompatible with aqueous conditions commonly deployed during sample prepa-ration. To overcome these solubility issues, MP studies commonly utilize detergent micelles. In recent years, numerous ef-forts have been directed toward developing membrane mimetics to facilitate successful solubilization and stabilization of MPs. Collision-induced dissociation (CID) can be employed to remove surrounding molecules from MPs during native mass spectrometry (nMS) experiments, and such methods can be used to evaluate previously inaccessible MPs. However, the dif-ferential effects of various membrane mimetics on MP structure and stability remain largely unexplored. In this study, we evaluate a range of MPs, including both transmembrane and monotopic variants, solubilized in detergent micelles, mixed lipid bicelles, and nanodiscs mimetics. Our findings reveal significant differences in collision induced unfolding (CIU) fea-tures, stabilities, collision cross-sections (CCS), and RMSD comparisons with values exceeding 26%. These results underscore the importance of considering the choice of membrane mimetics when studying MP structure.
Molecular Simulation Study of Elasticity of Fluid-Saturated Zeolites
Authors: Flores Roman Santiago , Emelianova Alina , Gor Gennady
Published: December 2024

Zeolites are widely used for applications involving gas adsorption thanks to their crystalline porous structure, high surface area, and mechanical stability. Experiments using magnetoelastic sensors showed that gas adsorption can noticeably alter the elastic moduli of zeolites. Here we utilized a combination of the classical molecular dynamics and Monte Carlo simulations to explore this effect in silico, calculating the bulk moduli of the zeolites, of the fluids adsorbed in these zeolites, and of the zeolite-fluid composites. We considered two gases -- nitrogen and carbon dioxide, in two zeolite structures -- 13X and 4A. The moduli of the composite systems were calculated using two alternative approaches: from the moduli of the constituents (unsaturated zeolite and adsorbed fluid) using the Gassmann equation, and directly, using the Birch-Murnaghan equation of state. The direct approach showed better agreement with the experimental observations, raising a question on the applicability of the Gassmann equation for microporous zeolites.
Kitchen Table Pedagogy: A Three-way Conversation on Animating Knowing and Becoming for Health Justice
Authors: Gingras Jacqui , Aphramor Lucy , Dark Kimberly
Published: December 2024

The three of us (be)come together, yes on Zoom calls and in Google docs, and in a way that re-imagines the sitting together at a well-worn kitchen table to animate our current shared preoccupations. The table has seen many conversations before us, so it’s well-worn by feminist scholars who were also troubled, yearning, and adamant about leaving their marks. We have come to, become at, this type of table for centuries, sitting together preparing food, folding laundry, and washing up, all while also reckoning that our stories matter and can make a difference. In a context that is both practical and intellectual – centring fat liberation in public health nutrition – how do we remain good scholarly support to one another in and through challenging times?
Times of dissent.
Times of tedium.
This chapter reveals the stories we need most now as we grapple with our places in the neoliberal university and public health pedagogy, specifically as a critique of policies that we read as non-liberatory. We grapple with how our complicity within these spaces might be considered from a place of mutual support and a shared commitment to unlearning and unsettling colonial ways of knowing, especially as we contemplate the problematics of public health imperatives regarding “intuitive eating” and health behaviour change. And we ask what this means for scholarship that is accountable to liberation, that is, personal survival and collective healing and learning.
Financial sources of business relocation and evacuation costs: international technical assistance and budget allocations
Authors: Svirko Svitlana , Panchenko Volodymyr , Sydorenko Oleksii
Published: December 2024

The purpose of this study was to substantiate the sources of covering the costs of relocation and evacuation of businesses in order to provide state support and assistance in the implementation of these processes. The article motivates the introduction of budget program 1201460 “Ensuring the implementation of business relocation and evacuation processes” within the framework of the budget procedure for the Ministry of Economy of Ukraine. The practical implementation of the specified budget program through the passport of the latter will allow the financial mechanism of state management of business relocation and evacuation processes to acquire a truly practical nature, which, in turn, will ensure the restoration of production potential at both the micro and macro levels. Given the extremely difficult situation of the state budget of our country, the use of: state credits and loans; international technical assistance in cash; grants for budget support is proposed as alternative sources of financial coverage of the above-mentioned expenses. At the same time, the role of the main beneficiary in the implementation of procedures for raising funds through these sources should be played by the Ministry of Economy of Ukraine. This approach will allow for full financial support for the implementation of business evacuation and relocation processes, which, in turn, will increase the efficiency and effectiveness of state management of these processes.
ПОДХОДЫ К ОПРЕДЕЛЕНИЮ ЭКОНОМИЧЕСКОЙ БЕЗОПАСНОСТИ СТРОИТЕЛЬНОГО КОМПЛЕКСА
Authors: ХАСБИУЛЛИНА ГУЗЕЛЬ МУХАММАТОВНА , ЕВСТАФЬЕВА АЛСУ ХУСАИНОВНА
Published: December 2024

В статье проводится анализ различных аспектов и методов оценки экономической безопасности строительного комплекса России. Рассматриваются такие подходы, как ресурсный, финансовый, институциональный, инфраструктурный и интеграционный, что дает возможность сделать вывод о ключевой роли синергетических эффектов между строительным комплексом и другими сферами экономики. Целью исследования является использование эконометрического подхода для оценки наличия данного эффекта и формирование основных подходов к определению экономической безопасности строительной сферы. Как прокси для нее был выбран показатель – объем работ, выполненных по виду экономической деятельности «строительство», для которого проведен анализ динамики и дифференциации. Результаты эконометрического моделирования показали необходимость комплексного подхода к обеспечению экономической безопасности строительного комплекса.
АКТУАЛИЗАЦИЯ НОМЕНКЛАТУРЫ ПАТЕНТНО-ПРАВОВЫХ ПОКАЗАТЕЛЕЙ КАЧЕСТВА ПОТРЕБИТЕЛЬСКИХ ТОВАРОВ В СОВРЕМЕННОМ ТОВАРОВЕДЕНИИ
Authors: ПАРШИКОВА ВАЛЕНТИНА НИКИТИЧНА , ШОТТ ОЛЬГА ИГОРЕВНА , ПЕТРЕНКО ЕЛЕНА ВАЛЕРЬЕВНА
Published: December 2024

Работа посвящена исследованию роли таких объектов интеллектуальной собственности из группы средств индивидуализации (СИ) продукции, как географические указания (ГУ) и наименования места происхождения товаров (НМПТ), в оценке её ассортимента и качества. Показано, что зарегистрированные ГУ и НМПТ могут служить своеобразными индикаторами качества товара, способствовать выявлению признаков контрафактности при нарушении права интеллектуальной собственности, а также свидетельствовать о развитии ассортимента оригинальной продукции с особыми свойствами в регионе. По статистическим данным Роспатента, информации открытого реестра ГУ и НМПТ, описаний к свидетельствам охарактеризовано состояние и структура ассортимента товаров с защищёнными СИ с 1992 по 2024 год. При этом выделен период с июля 2020 года после введения в оборот в РФ ГУ с описанием выявленных для него особенностей. Приведённые результаты показали наличие положительного эффекта от введения в правовое поле нового СИ. Заявки на регистрацию подают предприятия различной формы собственности и специализации, производящие непродовольственные товары и пищевые продукты. Более половины охранных документов зарегистрированы на пищевую и сельскохозяйственную продукцию, примерно треть — на разнообразные непродовольственные товары. Представлена сравнительная характеристика особых потребительских свойств регионального пищевого продукта с охраняемым ГУ. Приведён пример использования СИ товаров при выявлении признаков контрафактности. Оценено состояние, проблемы и перспективы использования продукции Красноярского края с зарегистрированными ГУ и НМПТ в качестве региональных брендов. Полученные данные свидетельствуют о необходимости активизации работы по охране региональной продукции ГУ и НМПТ, в том числе с целью повышения экспортного потенциала Красноярского края. Результаты исследования свидетельствуют о необходимости актуализации перечня патентно-правовых показателей товаров в теории товароведения и товарной экспертизы с целью последующего применения в практике промышленного и сельскохозяйственного производства, а также в сфере товарного обращения.
РЕГИОНАЛЬНЫЕ АСПЕКТЫ РАЗВИТИЯ ХЛЕБОПЕКАРНОЙ ПРОМЫШЛЕННОСТИ
Authors: ЧМЫШЕНКО ЕЛЕНА ГЕОРГИЕВНА
Published: December 2024

Актуальность исследования заключается в том, что в условиях жесткой конкуренции на рынке хлебопекарной продукции необходимо как на региональном уровне, так и на уровне отраслей и предприятий применять методы и инструменты стратегического управления. Методология исследования основана на использовании методов: диалектического, научной абстракции, анализа и синтеза, а также систематизации, сравнения, графического. В статье на основе стратегического анализа проведено исследование факторов внешней среды, влияющих на деятельность предприятий: политических, экономических, социокультурных и технологических. Представлена схема проведения стратегического анализа конкурентов на региональном рынке. На примере Оренбургской области рассмотрены отдельные этапы анализа конкурентов на рынке хлебобулочных изделий и представлены возможные стратегии, способствующие повышению их конкурентоспособности. Заключение. Решение выявленных проблем автор видит в необходимости повышения инвестиционной привлекательности хлебопекарной промышленности. Этому будет способствовать проведение качественного стратегического анализа, стратегического планирования, что является важным инструментом в конкурентной борьбе между предприятиями за рынки сбыта.
ТРАНСФОРМАЦИЯ ИНСТРУМЕНТОВ УПРАВЛЕНИЯ ПРОМЫШЛЕННОЙ ПОЛИТИКОЙ ПРЕДПРИЯТИЙ В УСЛОВИЯХ САНКЦИОННОЙ ТУРБУЛЕНТНОСТИ
Authors: ЛАЙПАНОВ АХМАТ ИСЛАМОВИЧ
Published: December 2024

В условиях санкционной турбулентности управление промышленной политикой российских предприятий требует глубокой трансформации. Особое внимание уделяется стратегическому развитию отечественных производственных мощностей в условиях ограниченного доступа к технологиям и рынкам. В статье исследуются современные инструменты управления промышленной политикой, направленные на ускоренное импортозамещение и сбалансированное развитие внутренней промышленной базы. С отраслевых особенностей предложены процедуры концептуальной модели управления импортозамещающей промышленной политикой предприятий пищевых производств и методы их реализации. Разработана модель гармонизированного управления промышленной политикой предприятия пищевых производств, обеспечивающая сбалансированное управление их ключевыми бизнес-процессами в условиях ограничений. Ее основные компоненты верифицированы в деятельности предприятия молочной промышленности ООО «Вита 1». Для определения результативности предложенных инструментов управления промышленной политикой предприятия пищевых производств сформирована комплексная методика оценки, позволяющая выявить проблемные сферы, требующие принятия управленческих решений.
НЕОБХОДИМОСТЬ ОЦЕНКИ ТУРИСТСКО-РЕКРЕАЦИОННОГО ПОТЕНЦИАЛА РЕГИОНА И ЕГО РОЛЬ
Authors: ВАРИВОДА ВАЛЕНТИНА СЕРГЕЕВНА
Published: December 2024

В последнее время в нашей стране появилось много предпринимательских структур, работающих в индустрии туризма и гостеприимства. Этот факт оказал влияние на расширение и развитие рынков внутреннего и международного туризма. Выход российских туристских фирм на международный рынок и появление на нашем туристском рынке новых зарубежных партнеров способствует формированию, развитию и расширению собственного конкурентного туристского рынка. При рассмотрении вопросов формирования отечественного туристского рынка имеет важное значение наличие продаваемого турпродукта и конкурентоспособных субъектов рыночного процесса. Информированность потенциальных продавцов и покупателей регионального туристского продукта становится крайне необходимой. Таким образом, выработка комплексной методики оценки туристско-рекреационного потенциала регионов требует рассмотрения вопросов развития как национальной индустрии туризма в пространстве территории нашей страны, так и вопросов функциональной обеспеченности туристско-рекреационными ресурсами индустриальной базы развития индустрии туризма. В связи с этим вопросы оценки туристско-рекреационного потенциала регионов требуют всестороннего и глубокого научного изучения, выработки механизма оценки его формирования и развития.
ВЗАИМОСВЯЗЬ ЭКОНОМИЧЕСКОЙ И ТЕХНОЛОГИЧЕКОЙ БЕЗОПАСНОСТИ ГОСУДАРСТВА В УСЛОВИЯХ ШЕСТОГО ТЕХНОЛОГИЧЕСКОГО УКЛАДА
Authors: ПАВЛОВ ВЯЧЕСЛАВ ИВАНОВИЧ , ШКОДИНСКИЙ СЕРГЕЙ ВСЕВОЛОДОВИЧ , ЗОИДОВ ХУРШЕДЖОН КОБИЛДЖОНОВИЧ
Published: December 2024

Цель работы. В статье рассматривается позиция авторов, согласно которой может быть обеспечена экономическая и технологическая безопасность в условиях шестого технологического уклада, но только при условии наличия суверенитета в экономике в полной мере триады предыдущих технологических укладов (третьего, четвертого и пятого), хотя не лишними будут наличие в экономике также первых двух технологических укладов. В процессе исследования использованы методы эволюционно-институциональной теории, эконометрического моделирования и аналитической оценки. Способствовать повышению эффективности российской экономики будет замена отжившей себя налоговой системы фискального типа инновационной парадигмой бюджетно-налоговой системы, тем более что в обращении Президента РФ В. Путина к федеральному собранию была поставлена задача модернизации налоговой системы фискального типа. Модернизация налоговой системы предусматривает переход к прогрессивной ставке налога на доходы физических лиц (НДФЛ), а также существенное повышение минимального размера оплаты труда (МРОТ).
Examining the Relationship Between Cannabis Use and Mood, Anxiety, and Psychotic Symptoms in Psychiatric Patients with Severe Concurrent Mental Health and Substance Use Disorders Before and After Recreational Cannabis Legalization in Canada
Authors: Thiessen Karina A. , Schutz Christian G.
Published: December 2024

Objective: The relationship between cannabis use and mental health has garnered significant attention in recent decades. However, studies have largely been in general populations or in countries in which recreational cannabis use is illegal. Method: The current cross-sectional study examines the relationship between cannabis use, mood disorders, anxiety, and psychosis in an inpatient psychiatric population with severe concurrent mental health and substance use disorders, exploring the potential moderating effect of the legalization of recreational cannabis in Canada. Results: Cannabis use compared to non-use was associated with higher self-reported depression, anxiety, and psychotic symptoms but was not associated with diagnosis of a mood, anxiety, or psychotic disorder. Frequency of cannabis use was unrelated to mental health outcomes, but age of first use was negatively associated with self-reported psychoticism symptoms. There were some significant associations between recreational cannabis legalization and mental health, but legalization was largely unrelated to outcomes. There were also some significant differences by demographics. Conclusions: While findings are relatively consistent with prior literature, some significant associations differed, suggesting the importance of examining concurrent disorder patients as a unique population when examining relationships between cannabis use and mental health.
АНАЛІЗ БЛОКЧЕЙНІВ НА МОЖЛИВОСТІ РОЗРОБКИ ДЕЦЕНТРАЛІЗОВАНИХ ЗАСТОСУНКІВ
Authors: Kavetskyi M. , Fedyushyn О. , Prosolov V. , Frolenko V.
Published: December 2024

Предметом дослідження є можливості блокчейн-платформ для розробки децентралізованих застосунків (DApps), з акцентом на продуктивність, масштабованість, розробку смарт-контрактів, екосистему, вартість транзакцій та відповідність регуляціям. Завдання статті полягає в аналізі платформ, визначенні їх сильних і слабких сторін та допомозі розробникам у виборі оптимальної технології для реалізації проєктів. Висновки: проведене дослідження показало, що блокчейни Aptos та Solana мають доволі непогані загальні характеристики для розробки більшості децентралізованих застосунків.
Observed changes in the characteristics of heat waves in hot and dry regions of Iran
Authors: Ansari Atefeh , Mahmoud Peyman , Nazaripour Hamid
Published: December 2024

Research on heat waves is greatly important not only due to their effect on
social, economic, and ecological systems, but also due to the complexity of the processes
that create them. Therefore, this research mainly investigated the trend of long-term
changes in various characteristics of heat waves in hot and dry regions of Iran. For this
purpose, the daily maximum temperature data of 15 meteorological stations in the central
and southeastern parts of Iran were used from 1985 to 2018. Using the excess heat factor
(EHF) index, five different features of heat waves including the number of heat waves
(HWN), heat waves duration (HWD), heat waves frequency (HWF), heat waves mean
(HWM), and heat waves magnitude (HWA) were extracted for all the studied stations.
Then, their trend of long-term changes was analyzed using the Sen’s slope estimator
nonparametric method. The results showed that on a regional scale, all five characteristics
of heat waves have an increasing trend at a significance level of 95%, so an increase of 0.5
events per decade has been observed for the HWN. The trend of long-term changes in the
HWD has also indicated an increase of 0.91 days per decade. The HWF has shown more
drastic changes than other characteristics of heat waves, so in every decade 2.61 days have
been added to the frequency of days contributing to the occurrence of heat waves. The
regional intensity of HWM and HWA also show an increase of 0.1 and 0.4 °C in each
decade, respectively. These findings show the importance of choosing a suitable index for
monitoring different characteristics of heat waves. The EHF index is a suitable index,
which can be one of the efficient indices in this regard.
Del desecho agrícola a la farmacia: potencial terapéutico del estigma de maíz para el tratamiento de diabetes
Authors: Rodríguez Valdez Luz María , Campos Almazán Mara Ibeth , Flores Mena Raúl Rodolfo , Landeros Martínez Linda Lucila , Sánchez Bojorge Nora Aydeé
Published: December 2024

En México, el maíz es un elemento fundamental en la dieta diaria formando parte de una gran variedad de alimentos tradicionales en el país. La tendencia en la producción de este cereal indica que, junto con el arroz, son los de mayor producción a nivel mundial, y México forma parte de los principales productores de este cereal. No obstante, el grano, hojas y silaje de maíz son mayormente aprovechados en la industria alimentaria y ganadera, pero el estigma de maíz es considerado desecho agrícola. Por otra parte, se ha observado que estos estigmas presentan actividad biológica, tales como actividad antidiabética. Por consiguiente, esta revisión presenta los avances actuales sobre el potencial terapéutico del estigma del maíz en el tratamiento parala diabetes tipo 2 y mecanismos de acción.
Salinidade da Água Superficial do Estado da Paraíba Geoespacializada por Modelagem B-Spline Multinível
Authors: Francisco Paulo Roberto Megna , Sousa José Hugo Simplicio de , Ribeiro George do Nascimento , Silva José Nilton , Saboya Luciano Fallé , Chaves Lucia Helena Garófalo , Nascimento Franciele Simões do
Published: December 2024

Este trabalho objetivou estimar e mapear a salinidade das águas superficiais do Estado da Paraíba para fins de irrigação. Foram obtidos dados de Condutividade Elétrica (CE) e os parâmetros de Cálcio (Ca2+), Magnésio (Mg2+) e Sódio (Na+) de 83 amostras de análises de água de açudes e rios de diversas fontes e utilizando o QGIS® foram geoespacializados utilizando a interpolação B-Spline Multinível através do plugin SAGA®. No software QUALIGRAF® foi realizada a classificação da água superficial para fins de irrigação. No tratamento estatístico foi realizada a análise descritiva dos dados e o teste de normalidade utilizando o software RStudio©. A interpolação apresentou resultados satisfatórios na modelagem por b-spline multinível. Os resultados estatísticos demonstraram maior variabilidade do Na+ e da Condutividade Elétrica das águas superficiais.  Os testes de normalidade apresentaram-se semelhantes entre si e a correlação entre o RAS e o CE foi de R=0,25. Em 81,69% do território apresentou classes de risco a salinidade baixa a média. A salinidade das águas superficiais para fins de irrigação apresentou classes de risco muito alto a excepcionalmente alto (C4S1 a C5S4) na região das sub-bacias e bacias hidrográficas do Seridó Oriental e no médio curso do rio Piranhas, seguida da região do médio curso do rio Paraíba.
Uji Efektivitas Plant Growth Promoting Rhizobacteria (PGPR) terhadap Pertumbuhan Tanaman dan Hasil Kacang Tanah (Arachis hypogaea L.)
Authors: Alifah Fatiah Rabani  , I Ketut Ngawit  , A. Farid Hemon
Published: December 2024

Produksi kacang tanah di Indoneisa dari tahun ke tahun semakin menurun. Upaya yang dapat dilakukan untuk meningkatkan pertumbuhan dan hasil kacang tanah yaitu dengan penggunaan varietas unggul dan pupuk hayati seperti Plant Growth Promoting Rhizobacteria (PGPR). Penelitian ini bertujuan untuk mengetahui efektivitas PGPR terhadap pertumbuhan dan hasil kacang tanah (Arachis hypogaea L.). Percobaan dilakukan pada bulan Februari sampai dengan Mei 2024 di Teaching Farm Desa Sigerongan, Kecamatan Lingsar, Kabupaten Lombok Barat. Rancangan yang digunakan pada percobaan ini adalah Rancangan Acak Kelompok (RAK)-Split plot design terdiri dari petak utama yaitu PGPR terdiri dari PGPR dan tanpa PGPR dan anak petak yaitu benih kacang tanah terdiri dari satu varietas Bison dan dua galur yaitu G300-II dan G19-UI. Setiap perlakuan diulang sebanyak 3 kali sehingga diperoleh 18 unit percobaan. Data dianalisis ragam dan di uji lanjut dengan Duncan pada taraf nyata 5%. Hasil Percobaan menunjukkan bahwa penggunaan PGPR efektif meningkatkan berat kering biomassa bagian atas tanah per tanaman yaitu 50,5 g dan menghasilkan berat kering polong per plot yaitu 4.293,3 g pada varietas Bison.
Stunting-Free Nasyiatul Aisyiyah (Pashmina) Health Service Program for Female Students of Muhammadiyah College Kotabaru, Pontianak
Authors: Ruhama Ufi , Yulian Ryani , Marlenywati Marlenywati , Khairunnisa Intan
Published: December 2024

This community service aims to increase the understanding of female students regarding nutrition and reproductive health. In addition, this health service activity owned by Nasyiatul Aisyiyah (PASHMINA) is a cadre program for the Regional Leadership of Nasyiatul Aisyiyah. In this activity, pengabdi conducted weight and height measurements as well as Body Mass Index (BMI) measurements. In this case there are 18 students classified as thin, 14 students classified as normal who are classified as obese less, namely 6 students. Before the material was given, the students filled out the pretest and after the presentation of the material by the resource person, the students completed the posttest. Pretest and posttest are carried out in order to determine the level of understanding of students related to the material that has been given. From the test results, it can be concluded that there is an increase in the understanding of female students by 38.98% after the material is given. This shows that the increase in understanding of female students related to stunting and reproductive health has increased. After this program is implemented, a Follow-up Plan (RTL) will be carried out between pengabdi and the Regional Leadership of Nasyiatul Aisyiyah Pontianak City in an effort to recruit early cadres in Nasyiah.
Strategi Penguatan Pendidikan Karakter di Era Digital: Tantangan dan Solusi dalam Implementasi di Sekolah
Authors: Muhamad Arif Nugraha  , Dinda Amanda AN  , Satria Kharimul Qolbi  , Waway Qodratullah S
Published: December 2024

Penelitian ini dilatarbelakangi oleh kebutuhan mendesak untuk memperkuat pendidikan karakter di era digital, di mana peserta didik dihadapkan pada tantangan moral dan sosial yang kompleks. Tujuan penelitian ini adalah untuk mengidentifikasi upaya dan strategi yang efektif dalam implementasi pendidikan karakter di Indonesia, dengan fokus pada integrasi nilai-nilai karakter dalam kurikulum nasional. Metode yang digunakan adalah studi pustaka (library research) yang mengkaji berbagai literatur terkait pendidikan karakter. Hasil penelitian menunjukkan bahwa integrasi pendidikan karakter dalam kurikulum nasional telah berhasil meningkatkan kesadaran peserta didik terhadap nilai-nilai moral, religiusitas, dan kebangsaan. Namun, tantangan yang dihadapi meliputi kurangnya dukungan dari pihak sekolah dan orang tua, keterbatasan waktu dalam kurikulum, serta kurangnya pelatihan khusus bagi pendidik. Untuk mengatasi tantangan ini, strategi yang direkomendasikan mencakup peningkatan pelatihan bagi pendidik, pengembangan bahan ajar yang menarik dan interaktif, serta kolaborasi antara sekolah, orang tua, dan komunitas lokal. Kesimpulan dari penelitian ini menekankan pentingnya pendekatan holistik dan sistematis dalam pendidikan karakter, yang adaptif terhadap perubahan sosial dan teknologi, guna mempersiapkan generasi muda Indonesia menghadapi tantangan global dengan karakter yang kuat dan bertanggung jawab.
Cadernos de Ensino, Pesquisa e Extensão volume 15: Pesquisa
Authors: Castro Marlon D'Oliveira , Santos Francisco Ewerton Almeida dos
Published: December 2024

o volume 15 dos Cadernos de Ensino, Pesquisa e Extensão, intitulado “Pesquisa”, é uma obra que consolida os esforços e a dedicação de pesquisadores, educadores e estudantes engajados na melhoria da educação básica em Colégios de Aplicação no Brasil. Este volume é especialmente significativo, pois compila os artigos resultantes dos trabalhos apresentados no XII Seminário de Institutos, Colégios e Escolas de Aplicação (XII SICEA), realizado na Universidade Federal do Pará (UFPA) em novembro de 2023.
I SIMPÓSIO DA ESCOLA DE NEGÓCIOS EM EMPREENDEDORISMO E ATUALIZAÇÃO PROFISSIONAL (ENEAP)
Authors: Pinto Victória Baía , Pinto Ricardo Figueiredo , Santos Marco Antônio Barros dos
Published: December 2024

É com grande entusiasmo que apresentamos o e-book do I Simpósio da Escola de Negócios em Empreendedorismo e Atualização Profissional (ENEAP). Este material representa o culminar de esforços voltados para o fortalecimento da educação, saúde, inovação e empreendedorismo na região Norte do Brasil, especialmente nos estados do Pará e do Amapá.

O I Simpósio ENEAP, realizado em dezembro de 2024, foi idealizado com o objetivo de responder às necessidades de acadêmicos e profissionais em busca de aprimoramento e destaque no mercado de trabalho. Com base nas experiências de um grupo comprometido com o desenvolvimento regional, foi possível reunir neste e-book uma seleção rica e diversificada de conteúdos.

Este volume contempla:
• 4 artigos científicos, que exploram temas relevantes e atuais;
• 6 projetos inovadores, trazendo soluções práticas para desafios enfrentados no mercado;
• Slides das apresentações de palestras, registrando as ideias e reflexões compartilhadas por especialistas e convidados.
Este evento presta uma homenagem especial aos mestres e doutores titulados pela Faculdade Interamericana de Ciências Sociais residentes no Estado do Amapá, cuja dedicação ao ensino, à pesquisa e à inovação tem sido uma fonte de inspiração para todos nós. São eles que, com seu conhecimento e comprometimento, pavimentam o caminho para uma sociedade mais qualificada, reflexiva e preparada para os desafios contemporâneos.
A cada mestre e doutor, deixamos o nosso profundo reconhecimento e gratidão. Vocês são a prova viva de que a educação transforma vidas, impulsiona carreiras e fortalece comunidades. Este e-book é também um reflexo do legado que vocês ajudam a construir, com impactos que transcendem as fronteiras acadêmicas.
A parceria com a Faculdade Interamericana de Ciências Sociais e com outros colaboradores fortaleceu a missão de consolidar a Escola de Negócios como um espaço de excelência e inovação, buscando sempre impulsionar o potencial de profissionais e acadêmicos.
Desejamos que este e-book seja não apenas um registro de conhecimentos, mas também uma fonte de inspiração e crescimento para todos os leitores. Estamos confiantes de que este é apenas o primeiro passo de uma trajetória de contribuições significativas para a educação, saúde, o empreendedorismo e a inovação
Agradecemos a todos os envolvidos e esperamos por novas colaborações em nossos futuros projetos. Boa leitura!
DESAFIOS E PERSPECTIVAS NO ALEITAMENTO MATERNO NA PRIMEIRA HORA DE VIDA: RELATO DE EXPERIÊNCIA EM UM CONTEXTO AMAZÔNICO
Authors: Silva Eliene Sousa da , Lima Nilcilene Sampaio , Menezes Thiago Alves , Ribeiro Mirla Rego
Published: December 2024

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Anais da III Jornada Acadêmica de Odontologia da Estácio
Authors: Santos Roniele Lima dos , Nunes Tereza Nicolle Burgos , Fontes Natasha Muniz , Vieira Lorena Vasconcelos , Laurentino Ferreira Filho José
Published: December 2024

A III Jornada Acadêmica de Odontologia da Estácio aconteceu nos dias 09, 10 e 11 de outubro de 2024 no polo Via Corpvs - Fortaleza. Contamos com 16 patrocinadores e 86 inscritos no evento. Foram 09 palestras com os temas de implantodontia digital, tecnologias endodônticas, marketing e posicionamento pessoal em HOF, harmonização orofacial, ortodontia, próteses bucomaxilofaciais, dentística, odontologia do esporte, entre outras. Além disso, também contamos com Hands-On de Fotografia Odontológica e de Preenchimento Labial.
Kepemimpinan Transformasional, Budaya Organisasi, Dan Motivasi Kerja: Dampaknya Pada Kinerja Pegawai Sektor Publik
Authors: Nafiudin  , Andari Andari , Yoebrilianti Anggit , Pratiwi Khadifa Puspa Ayu
Published: December 2024

This research aims to determine the influence of transformational leadership, organizational culture and work motivation on the performance of public sector employees. This research method uses quantitative methods with a population of 70 employees of the Serang Regency Communications, Informatics, Encryption and Statistics Service. The sampling technique in this research is a saturated sample. Saturated sampling is a sampling technique when all members of the population are sampled. The data sources obtained in this research were through observation, questionnaires and library research. Data analysis techniques were processed using the SPSS V.25 program. The results of this research were obtained using hypothesis testing which was carried out with a partial test (t test). The results show that, (1) transformational leadership has a positive and significant effect on employee performance. (2) Organizational culture has a significant negative effect on employee performance. (3) Work motivation has a positive and significant effect on employee performance
Mulheres camponesas na organização do trabalho associado: experiências e aprendizagens na ARPEP
Authors: Cabral Maria Neuza Machado , Zart Laudemir Luiz
Published: December 2024

This article is the result of research conducted during the Pedagogy course at Unemat. We investigated the experiences and learning of peasant women from the Regional Association of Extractive Producers of the Pantanal (ARPEP). The objective was to understand how women reconcile domestic activities and participate in collective groups, extract products from the land, produce food, receive professional training, organize an association and innovate their knowledge in organizational achievements. The scenario of implications aroused curiosity to know more about the lives of peasant women, their needs and achievements and how they organize their daily activities. In the methodology, we carried out field observation and four rounds of dialogues with peasant women workers. We based the analysis on critical and emancipatory pedagogy, to understand pedagogical and educational practices in non-school settings. The results present sociopolitical and cultural scenarios demonstrating organizational possibilities, achievements of rights and economic conditions by peasant women.
Produção de materiais pedagógicos (didáticos) em escolas indígenas: uma parceria entre universidades e aldeias
Authors: Ferreira Waldineia Antunes de Alcântara , Zoia Alceu , Almeida Elizabeth Rezende
Published: December 2024

Este texto discute a produção de materiais pedagógicos e/ou “didáticos” para as escolas indígenas, por meio do trabalho colaborativo coordenado pelos professores e com a participação de toda a comunidade das aldeias. Ou seja, trata-se de produções criadas a partir da funcionalidade do “Projeto Ação Saberes Indígenas na Escola” (ASIE), um projeto de extensão de formação continuada, que possibilitou uma aproximação das universidades com as aldeias indígenas e povos indígenas partícipes do projeto. A discussão do projeto de extensão se ancora no interior do projeto de pesquisa “Saberes indígenas na escola: a pesquisa e a produção colaborativa de materiais didáticos em aldeias”, que conta com o apoio da Fundação de Amparo à Pesquisa do Estado de Mato Grosso – FAPEMAT. Portanto, o objetivo deste artigo é avaliar em processos reflexivos o que os professores/as indígenas sentem e/ou avaliam o ASIE, considerando suas especificidades. Os colaboradores diretos nessa avaliação foram os coordenadores do ASIE Sinop-Juara. Metodologicamente, utilizamos da pesquisa qualitativa colaborativa com entrevistas semiestruturadas, via aplicativos de mensagens; e como resultados, podemos afirmar que os materiais produzidos nas aldeias têm evidenciado o protagonismo indígena e gerado empoderamento para todos envolvidos.
O professor do ensino superior: concepções a volta dos critérios de formação e de recrutamento de professores para o ensino superior em Moçambique
Authors: Choe Osvaldo Francisco de Carvalho , Chamo Bobone Dualia , Choé João Francisco de Carvalho
Published: December 2024

O estudo analisa a formação de professores universitários em Moçambique, evidenciando anecessidade de uma qualificação mais específica, além da formação acadêmica. Partiu-se da seguintehipótese: não se conhece ou é ignorado a diferença entre professor do ensino superior e indivíduo com nívelsuperior. O estudo qualitativo baseado em entrevistas com professores universitários e revisão bibliográfica,investigou a formação e perfil dos docentes do ensino superior. Utilizou se análise de conteúdo para identificarpadrões e temas recorrentes nos dados coletados. Os resultados indicam que, embora a maioria dos docentespossua mestrado ou doutorado, há uma carência de formação pedagógica específica. A pesquisa destaca anecessidade de uma formação mais específica em pedagogia, além da formação acadêmica, para garantira qualidade do ensino. Também destacou a importância de políticas públicas que incentivem a formaçãocontínua e desenvolvimento profissional dos docentes.
O ambiente natural como estímulo ao conhecimento científico na educação infantil: uma reflexão epistemológica
Authors: Rodrigues Teles Josenéia , Pontin Darsie Marta Maria , Franco Leão Marcelo
Published: December 2024

This article offers a bibliographical research that investigates the epistemological currents in the area of ​​teaching. The proposed objective is to reflect on the role of the natural environment as a stimulus to scientific knowledge for children in Early Childhood Education, through reflection based on epistemological theories. The methodology included a literature review in the Scielo, Google Scholar, Revista Eletrônica Olhar de Professor and Livros databases, using a qualitative approach. The results indicate that the natural environment can significantly stimulate scientific knowledge, providing a more contextualized and engaging approach to learning. The reflection highlights the importance of interaction, teacher mediation and active construction of scientific thinking.
Uma MODELAGEM MATEMÁTICA E O ENSINO DE FUNÇÕES: UMA ABORDAGEM PARA O ENSINO MÉDIO
Authors: Costa dos Santos Maurinete , Abreu de Assis Raul , Elias de Assis Luciana Mafalda
Published: December 2024

Este estudo tem como objetivo empregar a Modelagem Matemática como uma abordagem de ensino destinada a estudantes do Ensino Médio, utilizando o computador como uma ferramenta essencial para cálculos e representações. Utilizamos as funções afim, potência e exponencial para descrever a variação em relação ao tempo do fluxo de saída dos alunos após término do turno de aulas em uma escola estadual no Estado de Mato Grosso ao longo de três dias consecutivos. Por ser destinada ao Ensino Básico, apresentamos uma sequência didática para auxiliar o professor em como trabalhar uma atividade em que os alunos compreendam um problema real por meio da Modelagem Matemática, além de desenvolver habilidades com a utilização dos softwares Geogebra e Excel.