bluuebunny/crossref_metadata_2025 huggingface dataset:
Screening Method to Evaluate Amino Acid-Decarboxylase Activity of Bacteria Present in Spanish Artisanal Ripened Cheeses
Authors: Espinosa-Pesqueira Diana , Roig-Sagués Artur X. , Hernández-Herrero M. Manuela
Published: November 2018

A qualitative microplate screening method, using both low nitrogen (LND) and low glucose (LGD) decarboxylase broths, was used to evaluate the biogenic amine (BA) forming capacity of bacteria present in two types of Spanish ripened cheeses, some of them treated by high hydrostatic pressure. BA formation in decarboxylase broths was later confirmed by High Performance Liquid Chromatography (HPLC). An optimal cut off between 10–25 mg/L with a sensitivity of 84% and a specificity of 92% was obtained when detecting putrescine (PU), tyramine (TY) and cadaverine (CA) formation capability, although these broths showed less capacity detecting histamine forming bacteria. TY forming bacteria were the most frequent among the isolated BA forming strains showing a strong production capability (exceeding 100 mg/L), followed by CA and PU formers. Lactococcus, Lactobacillus, Enterococcus and Leuconostoc groups were found as the main TY producers, and some strains were also able to produce diamines at a level above 100 mg/L, and probably ruled the BA formation during ripening. Enterobacteriaceae and Staphylococcus spp., as well as some Bacillus spp. were also identified among the BA forming bacteria isolated.
Evaluation of 99 Pesticide Residues in Major Agricultural Products from the Western Highlands Zone of Cameroon Using QuEChERS Method Extraction and LC-MS/MS and GC-ECD Analyses
Authors: Galani Joseph H. Y. , Houbraken Michael , Wumbei Abukari , Djeugap Joseph F. , Fotio Daniel , Spanoghe Pieter
Published: November 2018

There is no information available on pesticide residue levels in major food commodities harvested in Cameroon, especially from the western highlands region, the food basket of the country. Hence, this study evaluated the residues of 99 pesticides in 72 samples of 12 agricultural products collected in the region, using QuEChERS (Quick, Easy, Cheap, Effective, Rugged, and Safe) method extraction, and analyzed by liquid chromatography tandem mass spectrometry (LC-MS/MS) and gas chromatography with electron capture detection (GC-ECD). This method was suitable for detecting the targeted compounds: For 81 pesticides by LC-MS/MS, the limit of quantification (LOQ) was between 0.0004 and 0.0537 mg/kg; and for 18 halogenated pesticides by GC-ECD, it ranged from 0.0012 to 0.2180 mg/kg. The residues of 62 pesticides, including 12 banned compounds, were found in the samples. Insecticides (39.7%) were the most prevalent group, with all the samples containing at least one pesticide. Twenty-one pesticides (34.4%) exceeded their European Union maximum residue limits (MRLs) and 22 pesticides (34.4%) were found in all 6 sampling locations. Malathion and p,p′-DDT were the most distributed pesticides, found in almost all the samples and sampling sites. Food items with the highest rates of positive results were chili pepper (23.2%), white pepper (20.2%), kidney beans (17.3%), and soybeans (17.2%). Samples with residues above their MRLs represented 38% of all the positive analyses; chili pepper (6.4%) and kidney beans (5.5%) were found to have the most residues above their MRLs. The most critical food commodities were kidney beans, soybeans, chili pepper, and maize. This data presents scientific evidence that investigation into continuous monitoring and good regulation of pesticide usage in Cameroon is needed, and paves the way for health risks analysis.
WebCircRNA: Classifying the Circular RNA Potential of Coding and Noncoding RNA
Authors: Pan Xiaoyong , Xiong Kai , Anthon Christian , Hyttel Poul , Freude Kristine K. , Jensen Lars Juhl , Gorodkin Jan
Published: November 2018

Circular RNAs (circRNAs) are increasingly recognized to play crucial roles in post-transcriptional gene regulation including functioning as microRNA (miRNA) sponges or as wide-spread regulators, for example in stem cell differentiation. It is therefore highly relevant to identify if a transcript of interest can also function as a circRNA. Here, we present a user-friendly web server that predicts if coding and noncoding RNAs have circRNA isoforms and whether circRNAs are expressed in stem cells. The predictions are made by random forest models using sequence-derived features as input. The output scores are converted to fractiles, which are used to assess the circRNA and stem cell potential. The performances of the three models are reported as the area under the receiver operating characteristic (ROC) curve and are 0.82 for coding genes, 0.89 for long noncoding RNAs (lncRNAs) and 0.72 for stem cell expression. We present WebCircRNA for quick evaluation of human genes and transcripts for their circRNA potential, which can be essential in several contexts.
Analysis of QualitySpec Trek Reflectance from Vertical Profiles of Taiga Snowpack
Authors: Leppänen Leena , Kontu Anna
Published: November 2018

Snow microstructure is an important factor for microwave and optical remote sensing of snow. One parameter used to describe it is the specific surface area (SSA), which is defined as the surface-area-to-mass ratio of snow grains. Reflectance at near infrared (NIR) and short-wave infrared (SWIR) wavelengths is sensitive to grain size and therefore also to SSA through the theoretical relationship between SSA and optical equivalent grain size. To observe SSA, the IceCube measures the hemispherical reflectance of a 1310 nm laser diode from the snow sample surface. The recently developed hand-held QualitySpec Trek (QST) instrument measures the almost bidirectional spectral reflectance in the range of 350–2500 nm with direct contact to the object. The geometry is similar to the Contact Probe, which was previously used successfully for snow measurements. The collected data set includes five snow pit measurements made using both IceCube and QST in a taiga snowpack in spring 2017 in Sodankylä, Finland. In this study, the correlation between SSA and a ratio of 1260 nm reflectance to differentiate between 1260 nm and 1160 nm reflectances is researched. The correlation coefficient varied between 0.85 and 0.98, which demonstrates an empirical linear relationship between SSA and reflectance observations of QST.
Dream Poems. The Surreal Conditions of Modernism
Authors: Mønster Louise
Published: November 2018

The article discusses three Swedish dream poems: Artur Lundkvist’s “Om natten älskar jag någon…” from Nattens broar (1936), Gunnar Ekelöf’s “Monolog med dess hustru” from Strountes (1955), and Tomas Tranströmer’s “Drömseminarium” from Det vilda torget (1983). These authors and their poems all relate to European Surrealism. However, they do not only support the fundamental ideas of the Surrealist movement, they also represent reservations about, and corrections to, this movement. The article illuminates different aspects of dream poems and discusses the status of this poetic genre and its relation to Surrealism throughout the twentieth century.
Health Literacy but Not Frailty Predict Self-Care Behaviors in Patients with Heart Failure
Authors: Son Youn-Jung , Shim Dae Keun , Seo Eun Koung , Seo Eun Ji
Published: November 2018

Heart failure (HF) is a chronic condition requiring continuous self-care. Health literacy is increasingly recognized as a key factor of self-care behaviors in patients with chronic diseases. Recently, frailty in chronic diseases has also been associated with self-care behaviors. However, relationships among health literacy, frailty, and self-care in the HF population are not well understood. Therefore, this cross-sectional study aimed to identify the impact of health literacy and frailty on self-care behaviors in patients with HF. Data were collected from 281 adults attending a cardiovascular outpatient clinic in Korea. Health literacy, frailty, and self-care behaviors were measured using Korean-validated instruments. The mean scores of health literacy and self-care behaviors were 8.89 (±3.44) and 31.49 (±5.38), respectively. The prevalence of frailty was around 26.3%. Health literacy was significantly associated with frailty and self-care behaviors. In a hierarchical linear regression analysis, health literacy was a significant determinant of self-care behaviors after adjusting for confounding variables, but frailty was not. Educational level was also a significant predictor of self-care behaviors. Our main findings showed that health literacy can facilitate improvements in HF self-care behaviors. Healthcare professionals should assess patients’ health literacy and educational backgrounds when designing self-management programs.
Distribution and Phytoavailability of Potentially Toxic Metals in Different Fe/Mg Mine Tailings
Authors: Yuan Xuyin , Wang Yimin , Tang Doudou , Zhang Xiaohui , Zhang Lei , Zhang Haiyan
Published: November 2018

The environmental risk of potentially toxic metals in tailing soils is of universal concern. We conducted a 3-month pot experiment to research the distribution and variations of potentially toxic metals (PTMs), and the translocation and accumulation capability of these metals (Cr, Ni, Mn, Cu, Zu) in natural plants for three Fe/Mg tailing soils (serpentine-type, olivine-type and magnetite-type) with growth of a grass plant-Imperata cylindrica. We used comparative analysis, regression analysis and correlation analysis to process relevant experimental data. Results showed the rhizosphere tailing soils decreased from 3.70% to 16.8%, compared to the bulk soils, after growth of Imperata cylindrica, and the acid soluble fraction of Mn, Cu and Zn increased significantly. Cu and Zn were more bioavailable than other PTMs, especially for serpentine-type tailing soils. Linear regression analysis indicated that non-residual fractions showed different effects on metal concentrations of Imperata cylindrica. The non-residual metal fractions of serpentine-type and olivine-type tailing soils showed better correlations with metal concentrations in grass plants than those of magnetite-type tailing soils. We found that the chemical compositions of tailing soils showed remarkable effects on Ni and Mn compared with other elements, especially Mg and Al. Overall, the grass plant can alter the metal distribution, enhance metal bioavailability and promote land use of Fe/Mg tailing soils.
Rapid Weight Loss and Dietary Inadequacies among Martial Arts Practitioners from Poland
Authors: Anyżewska Anna , Dzierżanowski Igor , Woźniak Agnieszka , Leonkiewicz Magdalena , Wawrzyniak Agata
Published: November 2018

Healthy nutrition and maintaining a normal body weight are very important for reducing the risk of various diseases not only among the general population, but also among athletes, especially combat sport athletes. The aim of the study was to evaluate the prevalence of rapid weight loss (RWL) and to indicate eventual dietary inadequacies among professional martial arts practitioners. Sixty-two male athletes (aged: 23 ± 4) completed a questionnaire (i.e., frequency of food group consumption, questions about training and RWL) and single 24-h dietary recall. This study confirmed the high prevalence of RWL in athletes (58%) for two to three days before the competition, which allowed for reduction of 3.4 ± 1.0 kg (4.3 ± 1.5%) of their body weight. Many dietary inaccuracies were found such as: lower than recommended by nutrition experts, level of consumption of dairy products, grain products, fruit, and vegetables, and insufficient intake of energy, carbohydrates, minerals (especially iodine, potassium, calcium) and vitamins (especially D, folate, C, E) during the training day. Adequate nutrition is a natural support for the whole training process, and may allow for regulation of body weight in a longer period and in a safer manner; thus, there is a need for nutrition education dedicated to athletes and their trainers.
Cigarette Smoking Modulation of Saliva Microbial Composition and Cytokine Levels
Authors: Rodríguez-Rabassa Mary , López Pablo , Rodríguez-Santiago Ronald E. , Cases Antonio , Felici Marcos , Sánchez Raphael , Yamamura Yasuhiro , Rivera-Amill Vanessa
Published: November 2018

Tobacco use has been implicated as an immunomodulator in the oral cavity and contributes to the development of oral cancer. In the present study, we investigated the effects of cigarette smoking on bacterial diversity and host responses compared to healthy nonsmoking controls. Saliva samples were collected from eighteen smokers and sixteen nonsmoking individuals by passive drool. The 16S rRNA gene was used to characterize the salivary microbiome by using the Illumina MiSeq platform. Cytokine and chemokine expression analyses were performed to evaluate the host response. Significant differences in cytokine and chemokine expression levels of MDC, IL-10, IL-5, IL-2, IL-4, IL-7, adrenocorticotropic hormone (ACTH), insulin, and leptin were observed between smokers and nonsmokers. Taxonomic analyses revealed differences between the two groups, and some bacterial genera associated with the smokers group had correlations with hormones and cytokines identified as statistically different between smokers and nonsmokers. These factors have been associated with inflammation and carcinogenesis in the oral cavity. The data obtained may aid in the identification of the interactions between the salivary microbiome, host inflammatory responses, and metabolism in smokers.
Lung Function Assessment as an Early Biomonitor of Mercury-Induced Health Disorders in Artisanal and Small-Scale Gold Mining Areas in Indonesia
Authors: Pateda Sri Manovita , Sakakibara Masayuki , Sera Koichiro
Published: November 2018

The evaluation of mercury impact on humans is currently nonspecific because the body characteristics (homeostasis) of each human being varies. Therefore, in the early diagnosis of mercury toxicity, one of the most important monitoring parameters is the respiratory function examination. In this study, respiratory function was examined with a portable spirometer and correlated with the mercury levels in hair from the noses and heads of subjects. Samples were taken from artisanal and small-scale gold mining (ASGM) areas (villages of East Tulabolo and Dunggilata) and control areas (villages of Bongo and Longalo) in Gorontalo Province, Indonesia. A statistical analysis with the Mann–Whitney test (alternative) showed significant differences in lung function between the polluted and control areas (α = 0.03). The analysis of nasal and head hair samples with particle-induced X-ray emissions (PIXE) showed that the mercury levels in the ASGM area were considerably higher than in the more homogeneous control areas. This study confirms that a pulmonary function test is a quick and precise alternative way to monitor the impact of mercury on humans, especially atmospheric mercury, because we detected a negative correlation between pulmonary function and the level of mercury in hair.
Use of a Multilayer Perceptron to Automate Terrain Assessment for the Needs of the Armed Forces
Authors: Pokonieczny Krzysztof
Published: November 2018

The classification of terrain in terms of passability plays a significant role in the process of military terrain assessment. It involves classifying selected terrain to specific classes (GO, SLOW-GO, NO-GO). In this article, the problem of terrain classification to the respective category of passability was solved by applying artificial neural networks (multilayer perceptron) to generate a continuous Index of Passability (IOP). The neural networks defined this factor for primary fields in two sizes (1000 × 1000 m and 100 × 100 m) based on the land cover elements obtained from Vector Smart Map (VMap) Level 2 and Shuttle Radar Topography Mission (SRTM). The work used a feedforward neural network consisting of three layers. The paper presents a comprehensive analysis of the reliability of the neural network parameters, taking into account the number of neurons, learning algorithm, activation functions and input data configuration. The studies and tests carried out have shown that a well-trained neural network can automate the process of terrain classification in terms of passability conditions.
An Automatic Recognition and Positioning Method for Point Source Targets on Satellite Images
Authors: Li Kai , Zhang Yongsheng , Zhang Zhenchao , Yu Ying
Published: November 2018

Currently, the geometric and radiometric calibration of on-board satellite sensors utilizes different ground targets using some form of manual intervention. Point source targets provide high precision geometric and radiometric information and have the potential to become a new tool for joint geometric and radiometric calibration. In this paper, an automatic recognition and positioning method for point source target images is proposed. First, the template matching method was used to effectively reduce nonpoint source target image pixels in the satellite imagery. The point source target images were then identified using particular feature parameters. Using the template matching method, the weighted centroid method, and the Gaussian fitting method, the positions of the centroid of the point source target images were calculated. The maximum position detection error obtained using the three methods was 0.07 pixels, which is comparably better than artificial targets currently in use. The experimental results show point source targets provide high precision geometric information, which can become a suitable alternative for automatic joint geometric and radiometric calibration of spaceborne optical sensors.
Crisis Maps—Observed Shortcomings and Recommendations for Improvement
Authors: Kuveždić Divjak Ana Kuveždić , Lapaine Miljenko
Published: November 2018

Cartographic communication through crisis maps takes place in a unique environment characterised by the immediate risks of considerable loss and stress. Many such maps are designed by practitioners with limited resources, pressured for time, and who often fail to pay the necessary attention to map graphics. This can reduce map clarity and make orientation to and understanding of essential crisis information difficult. To identify the most frequent shortcomings that may compromise the interpretation of depicted objects, phenomena presented, and actions required, we assessed the map graphics of 106 maps specifically designed for communication and action in crises. The results showed that they were often visually overloaded. Crisis data were not conveyed by appropriate cartographic representations, and due to the inappropriate use of visual variables, the associative and selective properties of cartographic symbols were overlooked, and their ordered and quantitative features ignored. The use of colour was often not adapted to conventional visual language, and colour symbolism was not always taken into account. The cartographic symbols used were often incomprehensible, illegible, ambiguous, and unclassified, and they lacked symbolism and hierarchical organisation. The article aims to address these problems by proposing guidelines which do not require much time or expertise, but which would ensure that cartographically correct crisis maps are well designed. Objects, phenomena or actions specific to crisis management would be indicated using appropriate map graphics and their importance highlighted, so as to make interpretation easier for all participants in a crisis event, and so facilitate crisis communication and response.
Apoprotein E and Reverse Cholesterol Transport
Authors: Getz Godfrey S. , Reardon Catherine A.
Published: November 2018

Apoprotein E (apoE) is a multifunctional protein. Its best-characterized function is as a ligand for low-density lipoprotein (LDL) receptor family members to mediate the clearance of apoB-containing atherogenic lipoproteins. Among its other functions, apoE is involved in cholesterol efflux, especially from cholesterol-loaded macrophage foam cells and other atherosclerosis-relevant cells, and in reverse cholesterol transport. Reverse cholesterol transport is a mechanism by which excess cellular cholesterol is transported via lipoproteins in the plasma to the liver where it can be excreted from the body in the feces. This process is thought to have a role in the attenuation of atherosclerosis. This review summarizes studies on the role of apoE in cellular cholesterol efflux and reverse cholesterol transport and discusses the identification of apoE mimetic peptides that may promote these pathways.
Induction of Expandable Adipose-Derived Mesenchymal Stem Cells from Aged Mesenchymal Stem Cells by a Synthetic Self-Replicating RNA
Authors: Miyagi-Shiohira Chika , Nakashima Yoshiki , Kobayashi Naoya , Kitamura Shinji , Saitoh Issei , Watanabe Masami , Noguchi Hirofumi
Published: November 2018

Adipose-derived mesenchymal stem cells (ADSCs) have attracted attention due to their potential for use in the treatment of various diseases. However, the self-renewal capacity of ADSCs is restricted and their function diminishes during passage. We previously generated induced tissue-specific stem cells from mouse pancreatic cells using a single synthetic self-replicating Venezuelan Equine Encephalitis (VEE)-reprogramming factor (RF) RNA replicon (SR-RNA) expressing the reprogramming factors POU class 5 homeobox 1 (OCT4), Krueppel-like factor 4 (KLF4), Sex determining region Y-box 2 (SOX2), and Glis Family Zinc Finger 1 (GLIS1). This vector was used to generate induced pluripotent stem (iPS) cells. Here, we applied this SR-RNA vector to generate human iTS cells from aged mesenchymal stem cells (hiTS-M cells) deficient in self-renewal that were derived from adipose tissue. These hiTS-M cells transfected with the SR-RNA vector survived for 15 passages. The hiTS-M cells expressed cell surface markers similar to those of human adipose-derived mesenchymal stem cells (hADSCs) and differentiated into fat cells and osteoblasts. Global gene expression profiling showed that hiTS-M cells were transcriptionally similar to hADSCs. These data suggest that the generation of iTS cells has important implications for the clinical application of autologous stem cell transplantation.
Signaling Pathways Induced by Leptin during Epithelial–Mesenchymal Transition in Breast Cancer
Authors: Olea-Flores Monserrat , Juárez-Cruz Juan Carlos , Mendoza-Catalán Miguel A. , Padilla-Benavides Teresita , Navarro-Tito Napoleón
Published: November 2018

Leptin is an adipokine that is overexpressed in obese and overweight people. Interestingly, women with breast cancer present high levels of leptin and of its receptor ObR. Leptin plays an important role in breast cancer progression due to the biological processes it participates in, such as epithelial–mesenchymal transition (EMT). EMT consists of a series of orchestrated events in which cell–cell and cell–extracellular matrix interactions are altered and lead to the release of epithelial cells from the surrounding tissue. The cytoskeleton is also re-arranged, allowing the three-dimensional movement of epithelial cells into the extracellular matrix. This transition provides cells with the ability to migrate and invade adjacent or distal tissues, which is a classic feature of invasive or metastatic carcinoma cells. In recent years, the number of cases of breast cancer has increased, making this disease a public health problem worldwide and the leading cause of death due to cancer in women. In this review, we focus on recent advances that establish: (1) leptin as a risk factor for the development of breast cancer, and (2) leptin as an inducer of EMT, an event that promotes tumor progression.
Insights into Tear Film Stability from Babies and Young Adults: A Study of Human Meibum Lipid Conformation and Rheology
Authors: Mudgil Poonam , Borchman Douglas , Ramasubramanian Aparna
Published: November 2018

Babies have the most stable tears and people with dry eye have the least stable tears. Meibum may contribute to tear film stability, so in this study, the hydrocarbon chain conformation and rheology of meibum from babies was studied for the first time. Infrared spectroscopy was used to measure lipid phase transitions. Rheology was measured using Langmuir film technology. Meibum from 25 donors 1 to 13 years old was compared with meibum from 18 donors 13 to 25 years old. The phase transition temperature and lipid order (stiffness) increased with increasing age from 1 to 25 years. The increase in meibum lipid order from 1 to 25 years of age may contribute to the instability of the tear film with age and contribute to films with a higher reciprocal compressibility modulus that are not as compressible and not as viscoelastic. Changes in the lipid phase transition parameters of meibum lipid with dry eye are an exacerbation of the changes observed with age. The lower reciprocal compressibility moduli of meibum films from children and babies compared with meibum from adults reiterates higher stability in their films which spread better, resist deformation, and facilitates their ability to be quickly restored after blinking.
Conversion of the English-Xhosa Dictionary for Nurses to a Linguistic Linked Data Framework
Authors: Gillis-Webber Frances
Published: November 2018

The English-Xhosa Dictionary for Nurses (EXDN) is a bilingual, unidirectional printed dictionary in the public domain, with English and isiXhosa as the language pair. By extending the digitisation efforts of EXDN from a human-readable digital object to a machine-readable state, using Resource Description Framework (RDF) as the data model, semantically interoperable structured data can be created, thus enabling EXDN’s data to be reused, aggregated and integrated with other language resources, where it can serve as a potential aid in the development of future language resources for isiXhosa, an under-resourced language in South Africa. The methodological guidelines for the construction of a Linguistic Linked Data framework (LLDF) for a lexicographic resource, as applied to EXDN, are described, where an LLDF can be defined as a framework: (1) which describes data in RDF, (2) using a model designed for the representation of linguistic information, (3) which adheres to Linked Data principles, and (4) which supports versioning, allowing for change. The result is a bidirectional lexicographic resource, previously bounded and static, now unbounded and evolving, with the ability to extend to multilingualism.
Instrumentation for Simultaneous Non-Destructive Profiling of Refractive Index and Rare-Earth-Ion Distributions in Optical Fiber Preforms
Authors: Vivona Marilena , Zervas Michalis N.
Published: November 2018

We present a non-destructive technique for a combined evaluation of refractive index and active-dopant distribution in the same position along a rare-earth-doped optical fiber preform. The method relies on luminescence measurements, analyzed through an optical tomography technique, to define the active dopant distribution and ray-deflection measurements to calculate the refractive index profile. The concurrent evaluation of both the preform refractive index and the active dopant profiles allows for an accurate establishment of the dopant distribution within the optical core region. This combined information is important for the optimization and development of a range of advanced fibers, used, for example, in a high-power fiber lasers and modern spatial-division-multiplexing optical communication systems. In addition, the non-destructive nature allows the technique to be used to identify the most appropriate preform segment, thus increasing fiber yield and reducing development cycles. We demonstrate the technique on an Yb3+-doped aluminosilicate fiber preform and compare it with independent refractive index and active-dopant measurements. This technique will be useful for quality evaluation and optimization of optical fiber preforms and lends itself to advanced instrumentation.
Systemic Capillary Leak Syndrome (Clarkson Syndrome) in Cancer Patients: A Systematic Review
Authors: Shin Jae Il , Lee Keum Hwa , Lee I. Re , Oh Ji Hyun , Kim Dong Wook , Shin Jae Won , Eo Tae Seong , Kronbichler Andreas , Eisenhut Michael , Van der Vliet Hans J.
Published: November 2018

Systemic capillary leak syndrome (SCLS) is a rare disease characterized by shock caused by capillary hyperpermeability. The disease can occur in cancer patients and effective therapeutic strategies have not been established yet. The aim of the study was to analyze the clinical and laboratory data, treatment modalities, and mortality rate of patients and to identify contributing factors leading to mortality of SCLS in cancer. We searched MEDLINE (inception to July 2018) and of 4612 articles, we identified 62 case reports on SCLS associated with cancer or cancer-related drugs in a total of 53 articles. SCLS was associated with cancer itself in 43.6%, with anti-cancer agents in 51.6% and bone marrow transplantation (BMT) in 4.8%. Among anti-cancer agents, granulocyte-colony stimulating factor (G-CSF) was the most frequently associated drug (14.6%), followed by interleukin (IL)-2 (11.4%). The most common associated malignancies were hematologic (61.3%) with non-Hodgkin lymphoma (22.7%) and multiple myeloma (12.9%) being the leading causes. Common symptoms and signs included dyspnea (27.4%), edema (67.7%), hypotension (32.2%), pleural effusion (29.0%), ascites (22.7%), oliguria (22.7%), and weight gain (21.0%). Patients with SCLS were treated with steroids (59.7%), volume replacement (33.8%), diuretics (24.2%), inotropes (9.6%), methylxanthines (12.8%), β2 agonists (4.8%), while intravenous immunoglobulins (IVIG) were administered in 2 patients (3.2%) only. Among sixteen deaths during follow-up, four were directly attributed to SCLS. Hematologic malignancies were associated with an increased risk for mortality (hazard ratio (HR) 8.820, 95% confidence interval (CI) 1.126–69.063, p = 0.038). Taken together, SCLS can be one important adverse event in cancer patients and careful monitoring of fluid volume is required in the management of SCLS.
Modelling Behaviour of the Salt Wedge in the Fraser River and Its Relationship with Climate and Man-Made Changes
Authors: Tsz Yeung Leung Albert , Stronach Jim , Matthieu Jordan
Published: November 2018

Agriculture is an important industry in the Province of British Columbia, especially in the Lower Mainland where fertile land in the Fraser River Delta combined with the enormous water resources of the Fraser River Estuary support extensive commercial agriculture, notably berry farming. However, where freshwater from inland meets saltwater from the Strait of Georgia, natural and man-made changes in conditions such as mean sea level, river discharge, and river geometry in the Fraser River Estuary could disrupt the existing balance and pose potential challenges to maintenance of the health of the farming industry. One of these challenges is the anticipated decrease in availability of sufficient freshwater from the river for irrigation purposes. The main driver for this challenge is climate change, which leads to sea level rise and to reductions in river flow at key times of the year. Dredging the navigational channel to allow bigger and deeper vessels in the river may also affect the availability of fresh water for irrigation. In this study, the salinity in the river was simulated using H3D, a proprietary three-dimensional hydrodynamic numerical model which computes the three components of velocity (u,v,w) in three dimensions (x,y,z) on a curvilinear grid developed specially for Fraser River, as well as scalar fields such as salinity and temperature. The results indicate various levels of impact to the salinity in the river and adaptive measures must be established to maintain the long-term viability of the industry. This study found that sea level rise and changes in river discharge would have a larger impact on the availability of fresh water than would channel deepening at the present sea water level. In a low river discharge regime, the impact from sea level change is more significant than in the high river discharge regime. On the other hand, the influence from changes in river discharge on withdrawal appears to increase when water level is lowered. Dredging the channel to accommodate larger vessels with deeper draft would further affect the salinity and shorten the withdrawal window; the effect of channel deepening becomes more pronounced in the lower flow period.
Caenorhabditis elegans as a Model Host to Monitor the Candida Infection Processes
Authors: Elkabti Asmaa B. , Issi Luca , Rao Reeta P.
Published: November 2018

C. elegans has several advantages as an experimental host for the study of infectious diseases. Worms are easily maintained and propagated on bacterial lawns. The worms can be frozen for long term storage and still maintain viability years later. Their short generation time and large brood size of thousands of worms grown on a single petri dish, makes it relatively easy to maintain at a low cost. The typical wild type adult worm grows to approximately 1.5 mm in length and are transparent, allowing for the identification of several internal organs using an affordable dissecting microscope. A large collection of loss of function mutant strains are readily available from the C. elegans genetic stock center, making targeted genetic studies in the nematode possible. Here we describe ways in which this facile model host has been used to study Candida albicans, an opportunistic fungal pathogen that poses a serious public health threat.
Institutional Functionality in Participatory Integrated Watershed Development of Tana Sub-Basin, Ethiopia
Authors: Tesfaye Gebremedn , Alamirew Tena , Kebede Asfaw , Zeleke Gete
Published: November 2018

Sustaining watersheds that were developed through community mobilization are a major challenge in Ethiopia despite significant efforts to promote soil and water conservation technologies and approaches. This paper investigates the hypothesis that institutional rationality and functionality play an important role in developing enduring watersheds by comparing the good performing Model research watersheds and adjacent watersheds developed through extensively promoted community mobilization. A semi-qualitative research method was used by applying a multi-stage purposive sampling technique for selecting sample respondents. Based on the new institutional economic theory, twelve effective institutional indicators were devised for the evaluation. Questionnaires were designed and tested to solicit respondents’ perceptions on these indicators. Data were analyzed using the Mann-Whitney test. The results showed that significant differences were observed between the two watershed groups in relation to good interaction (p = 0.03) and technical rationality (p = 0.04). Most of the institutional characteristics and rationalities that led to better performance in the case of the Model research watershed were lacking in the community watersheds. In the Model watersheds, effective institutional characteristics and rationalities contributed to enhanced natural resource conservation, increased incomes, improved household food security, and provided additional social benefits. The most important lesson is that close follow-up and informed engagement leads to a speedy recovery and the sustainability of Community watersheds from implementing modest re-orientation of the existing institutional arrangements.
Assessing the Spatial Drivers of Land Use and Land Cover Change in the Protected and Communal Areas of the Zambezi Region, Namibia
Authors: Kamwi Jonathan M. , Cho Moses A. , Kaetsch Christoph , Manda Samuel O. , Graz Friedrich P. , Chirwa Paxie W.
Published: November 2018

Understanding the patterns and drivers of land use and land cover (LULC) changes is fundamental for rational and specific planning for sustainable land management. Using remote sensing techniques, geographic information systems (GIS) and statistical modeling via multinomial logistic regression, we sought to identify spatial variables that determine LULC change and their extent over time in the protected and communal areas of the Zambezi Region, Namibia. Multi-temporal satellite imagery of the Landsat series was used to map changes over a period of twenty-six years, divided into three stages (1984–1991, 1991–2000 and 2000–2010). Post classification change detection methodologies were used to determine conversions between LULC classes. Additionally, socio-economic characteristics of the area were used to identify drivers of changes. Four spatial drivers of LULC change that we identified included the distance to the nearest road, distance to settlements, population density and fire return periods. Population density, distance to settlements and fire return period were significantly associated with conversion from crop/grass land to crop/grass land and forest land to crop/grass, forest land to bare land and forest land to forest land in the protected area. In communal areas, distance to the road was found to significantly influence conversion from crop/grass land to crop/grass land. The study concluded that the influence of these drivers is attributable to distinct political and agro-demographical differences during the study period. Policy makers and planners need to take these drivers into consideration together with their subsidiaries to respond and make sound decisions regarding undesirable changes in LULC.
Preparation and Characterization of Expanded Clay-Paraffin Wax-Geo-Polymer Composite Material
Authors: Hassan Ahmed , Ismail Najif , Mourad Abdel-Hamid I. , Rashid Yasir , Laghari Mohammad S.
Published: November 2018

Paraffin-based phase change material (PCM) is impregnated into the pores of lightweight expanded clay aggregate (LECA) through vacuum impregnation to develop PCM containing macro-capsules of LECA. Three different grades of LECA varying in size and morphology are investigated to host the PCM to determine the impregnation effectiveness, viability for coating, and its stability. The produced LECA-PCM is coated with geopolymer paste (GP) to provide leak proofing during the phase change. The PCM is thermophysically characterized by employing differential scanning calorimetry (DSC) and the temperature history method (THM) to determine the phase transition and the latent heat. The stability of the macro-capsules is determined by weight loss through rapid thermal cycling (RTC) at elevated temperatures. Leakage of the PCM is tested using the diffusion-oozing circle test (DOCT). The results show that the GP coated LECA-PCM macro-capsules achieved 87 wt % impregnation efficiencies and no noticeable loss of PCM, which indicates leak proofing of the developed capsules up to 1000 RTC.
Improving the Water Resistance and Mechanical Properties of Feather Keratin/Polyvinyl Alcohol/Tris(Hydroxymethyl)Aminomethane Blend Films by Cross-Linking with Transglutaminase, CaCl2, and Genipin
Authors: Wu Shufang , Chen Xunjun , Yi Minghao , Ge Jianfang , Yin Guoqiang , Li Xinming
Published: November 2018

The high moisture sensitivity of feather keratin/polyvinyl alcohol/tris(hydroxymethyl)aminomethane (FK/PVA/Tris) blend films hinders their application in the packaging field. Thus, in order to improve the water resistance and mechanical properties of such blend films, we attempted cross-linking the blend film with cross-linking agents such as transglutaminase (TG), CaCl2, and genipin. Obvious differences in the morphology of the blended films were observed by scanning electron microscopy before and after cross-linking, indicating that cross-linking can inhibit the phase separation of the blend film. Conformational changes in the blend films after cross-linking were detected by Fourier transform infrared spectroscopy. Importantly, from examination of the total soluble mass, contact angle measurements, and water vapor permeability tests, it was apparent that cross-linking greatly improved the water resistance of the blend films, in addition to enhancing the mechanical properties (i.e., tensile strength and elongation at break). However, cross-linking was also found to reduce the oxygen barrier properties of the blend films. Therefore, cross-linking appears to be an effective method for promoting the application of FK/PVA/Tris blend films in the packaging field.
Thermal and Mechanical Properties of Expanded Graphite/Paraffin Gypsum-Based Composite Material Reinforced by Carbon Fiber
Authors: Zhang Bo , Tian Yuanyuan , Jin Xiaoyan , Lo Tommy Y. , Cui Hongzhi
Published: November 2018

Phase change material (PCM) is a kind of thermal energy storage material. Solid-liquid PCM composite materials must overcome the issues of material leakage and low thermal conductivity before they are suitable for widespread use in the fields of building and industry. In this study, porous expanded graphite (EG) is used as a carrier, which absorbs the PCM to fabricate EG/paraffin composites (EG/P) containing 90.6% paraffin, and a latent heat of up to 105.3 J/g was measured. Because gypsum board is widely used in buildings, therefore, EG/P composites are suitable to be integrated into gypsum to develop expanded graphite/paraffin gypsum-based composite material (EGPG) for thermal energy storage. In order to optimize the performance of EGPG, carbon fiber (CF) is used to reinforce their thermal and mechanical properties. The test results show that when 1 wt % CF is incorporated into the EGPG, the thermal conductivity increased 36.0%, and thus EGPG shows superior thermal control through the significantly increased efficiency of heat transfer. After 1 wt % CF was added, the flexural and compressive strength of EGPG were increased by 65.6% and 6.4%, respectively. The improved thermal and mechanical performance of EGPG modified by CF demonstrates that it is a structural-functional integrated building material suitable for building envelope system.
Combining the Photocatalysis and Absorption Properties of Core-Shell Cu-BTC@TiO2 Microspheres: Highly Efficient Desulfurization of Thiophenic Compounds from Fuel
Authors: Liu Jing , Li Xiao-Min , He Jing , Wang Lu-Ying , Lei Jian-Du
Published: November 2018

A core-shell Cu-benzene-1,3,5-tricarboxylic acid (Cu-BTC)@TiO2 was successfully synthesized for photocatalysis-assisted adsorptive desulfurization to improve adsorptive desulfurization (ADS) performance. Under ultraviolet (UV) light irradiation, the TiO2 shell on the surface of Cu-BTC achieved photocatalytic oxidation of thiophenic S-compounds, and the Cu-BTC core adsorbed the oxidation products (sulfoxides and sulfones). The photocatalyst and adsorbent were combined using a distinct core-shell structure. The morphology and structure of the fabricated Cu-BTC@TiO2 microspheres were verified by scanning electron microscopy, high-resolution transmission electron microscopy, energy-dispersive x-ray spectroscopy, X-ray powder diffraction, nitrogen adsorption-desorption and X-ray photoelectron spectroscopy analyses. A potential formation mechanism of Cu-BTC@TiO2 is proposed based on complementary experiments. The sulfur removal efficiency of the microspheres was evaluated by selective adsorption of benzothiophene (BT) and dibenzothiophene (DBT) from a model fuel with a sulfur concentration of 1000 ppmw. Within a reaction time of 20 min, the BT and DBT conversion reached 86% and 95%, respectively, and achieved ADS capacities of 63.76 and 59.39 mg/g, respectively. The BT conversion and DBT conversion obtained using Cu-BTC@TiO2 was 6.5 and 4.6 times higher, respectively, than that obtained using Cu-BTC. A desulfurization mechanism was proposed, the interaction between thiophenic sulfur compounds and Cu-BTC@TiO2 microspheres was discussed, and the kinetic behavior was analyzed.
Degenerate Daehee Numbers of the Third Kind
Authors: Pyo Sung-Soo , Kim Taekyun , Rim Seog-Hoon
Published: November 2018

In this paper, we define new Daehee numbers, the degenerate Daehee numbers of the third kind, using the degenerate log function as generating function. We obtain some identities for the degenerate Daehee numbers of the third kind associated with the Daehee, degenerate Daehee, and degenerate Daehee numbers of the second kind. In addition, we derive a differential equation associated with the degenerate log function. We deduce some identities from the differential equation.
Bilateral Optic Neuritis Secondary to Nivolumab Therapy: A Case Report
Authors: Kartal Ömer , Ataş Erman
Published: November 2018

Pediatric glioblastoma multiforme is an uncommon and highly mortal brain cancer. New therapeutic treatments are being intensively investigated by researchers in order to extend the survival of patients. The immune checkpoint inhibitor nivolumab in the treatment of pediatric glioblastoma multiforme is currently under review; it is a human immunoglobulin G4 monoclonal antibody that works against the programmed cell death protein 1 receptor, designed to enhance an immunologic reaction against cancer cells. Herein, we describe the first report of a bilateral optic neuritis induced by nivolumab in a grade 4 glioblastoma multiforme patient.
Effect of Immersion Depth of a Swirling Flow Tundish SEN on Multiphase Flow and Heat Transfer in Mold
Authors: Ni Peiyuan , Ersson Mikael , Jonsson Lage T. I. , Zhang Ting-An , Jönsson Pär Göran
Published: November 2018

The effect of the immersion depth of a new swirling flow tundish SEN (Submerged Entry Nozzle) on the multiphase flow and heat transfer in a mold was studied using numerical simulation. The RSM (Reynolds Stress Model) and the VOF (Volume of Fluid) model were used to solve the steel and slag flow phenomena. The results show that the SEN immersion depth can significantly influence the steel flow near the meniscus. Specifically, an increase of the SEN immersion depth decreases the interfacial velocity, and this reduces the risk for the slag entrainment. The calculated Weber Number decreases from 0.8 to 0.2 when the SEN immersion depth increases from 15 cm to 25 cm. With a large SEN immersion depth, the steel flow velocity near the solidification front, which is below the mold level of SEN outlet, was increased. The temperature distribution has a similar distribution characteristic for different SEN immersion depths. The high temperature region is located near the solidification front. Temperature near the meniscus was slightly decreased when the SEN immersion depth was increased, due to an increased steel moving distance from the SEN outlet to the meniscus.
Determination of Residual Stresses in an Oxidized Metallic Alloy under Thermal Loadings
Authors: Wang Zhimao , Grosseau-Poussard Jean-Luc , Panicaud Benoît , Geandier Guillaume , Renault Pierre-Olivier , Goudeau Philippe , Boudet Nathalie , Blanc Nils , Rakotovao Felaniaina , Tao Zhaojun
Published: November 2018

In order to clarify the mechanical features of a metal under thermal cyclic loading for the system Ni30Cr- Cr 2 O 3 , a specific study has been carried out. In the present work, the residual stresses in both the metal and the oxide layer have been investigated. An adapted method is applied to process the experimental results that were obtained by using in-situ high temperature synchrotron diffraction at European Synchrotron Radiation Facility. The sin 2 ψ analysis provides information about the stress in metal and oxide. X-ray diffraction provides also the lattice parameter between crystallographic planes in the metal. To obtain correct stress values, a correction method is also proposed taking into account different discrepancies sources to ensure the equation of mechanical balance.