bluuebunny/crossref_metadata_2025 huggingface dataset:
Fluorine anion modification of high-voltage Mn-rich phosphate cathodes for high-power and long-lasting sodium-ion batteries
Authors: Zhang Wei , Wu Yulun , Xu Zhenming , Li Jianwei , Dai Yuhang , Zong Wei , Chen Ruwei , Li Shihao , Guo Fei , Li Simin , Wu Feixiang , Zhang Zhian , He Guanjie , Lai Yanqing , Parkin Ivan
Published: July 2022

High-voltage cathodes with high power and stable cyclability are needed for future high-performance sodium-ion batteries. However, the low electronic conductivity and poor capacity retention impede the development of Mn-rich phosphate cathodes. Here, a light-weight F doping strategy is reported to modify high-voltage Na4MnCr(PO4)3 cathodes. The light-weight F dopant could decrease the energy gap to 0.22 eV from 1.52 eV and strengthen the adjacent chemical bonding around Mn as confirmed by density functional theory calculations, which ensure the boosted electronic conductivity and suppress Mn dissolution. The combination of in-situ and ex-situ techniques determine that the F dopant has no influence on the Na+ storage mechanisms. As a result, an outstanding rate performance up to 40 C and an improved cycling stability (1000 cycles at 20 C) are thus achieved (best reported performances until now). This work presents an unusual and widely available light-weight anion doping strategy for high-performance polyanionic cathodes.
Postoperative multidimensional risk factor analysis and nomogram construction in patients with non-small-cell lung cancer
Authors: Wu Lei , Yang Shanlan , Wang Nan , Zhang Pin , Chen Xintai , Dai Xiwang , Yu Chao , Jiang Han
Published: July 2022

BackgroundThe aim of this study was to investigate the multidimensional factors affecting overall survival (OS) and progression-free survival (PFS) of patients undergoing non-small-cell lung cancer (NSCLC) resection, and to construct nomograms for visualization based on the consideration of competing risk events.MethodsThis was a prospective, longitudinal cohort study conducted in the Second Affiliated Hospital of Nanchang University from to 2015-2021. We actively collected multidimensional information from 674 patients with NSCLC who underwent surgery in the first three years and were followed up for three years postoperatively. A competitive risk model was used to analyze the factors affecting the prognosis of patients with NSCLC, and a nomogram was developed for individualized evaluation. The effectiveness of the prediction models was measured using the concordance index (C-index), receiver operating characteristic (ROC) curve, and calibration curve.ResultsAge at surgery, number of lymph nodes (LNs) obtained during surgery, T stage, N stage, and prognostic nutritional index (PNI) can predict OS. Addition of adjuvant therapy to this basis can predict PFS. The C-index for the OS nomogram was 0.778 and the AUC was 0.788 (95% CI: 0.667–0.762). The C-index for the PFS nomogram was 0.751 and the AUC was 0.750 (95% CI: 0.681–0.820). The 2-year and 3-year calibration curves also showed good predictive performance.ConclusionsAge at surgery, number of lymph nodes, T stage, N stage, PNI, and adjuvant therapy are relevant in the prognostic evaluation of NSCLC patients undergoing surgery, and the constructed nomograms and competing risk models have good predictive value.
Prevalence of the anconeus epitrochlearis muscle in a Turkish population and its general characteristics on magnetic resonance imaging
Authors: Duran Semra , Gunaydin Elif , Cayhan Velihan
Published: July 2022

Introduction: The anconeus epitrochlearis (AE) muscle is an accessory muscle located between the medial cortex of the olecranon and the inferior surface of the medial epicondyle, posterior to the ulnar nerve. We aimed to determine the gender and side characteristics of the AE muscle in patients who underwent elbow magnetic resonance imaging (MRI) and report its prevalence in a Turkish population.Materials and Methods: A total of 209 patients (210 elbows) who underwent elbow MRI between January and December 2020 were retrospectively evaluated. Cases with the AE muscle were included in the study. The craniocaudal (CC) dimension was examined from the coronal section, and the transverse (TR) and anteroposterior (AP) dimensions from the axial sections. Statistical analyses were performed to determine the relationship between the presence of the AE muscle and age, gender, and side (right/left). Differences between sexes and sides in terms of muscle sizes were evaluated using statistical tests.Results: The AE muscle was detected in 17 patients (18 elbows) (8.1%). The mean age of the patients was 41.52 ± 14.63 years. There was no statistically significant difference between the male and female patients in terms of age. This accessory muscle was found in nine female (9.8%) and eight male (6.3%) patients in total. There was one (0.5%) patient with the bilateral AE muscle, who was female. The accessory muscle was located in the right elbow in 13 patients (10.71%), and left elbow in five (4.10%). It was more common in the right elbow in both genders. The muscle was larger in the male patients and the right elbow, but this was not statistically significant.Conclusion: The prevalence of the AE muscle was determined to be 8.1% in a Turkish population, and this muscle was more common among the women and in the right elbow.
Comparison of extra virgin olive oil (Olea Europea L.) and soybean oil (Glycine max L. Meer) subjected to adulteration
Authors: Ariza-Ortega José Alberto , Ariza-Torres Diana Gabriela , Trinidad Eva María Molina , Reyes Joel Díaz
Published: July 2022

The objective of this work was to compare extra virgin olive oil (EVOO) and soy oil (SO) subjected to adulteration. Two commercial brand oils were used. The adulteration of the EVOO was carried out by adding SO at 50/50%, 40/60%, 30/70%, 20/80% and 10/90% respectively. For each of the samples, relative density (δ), acidity index (AI) and refractive index (RI) were determined. The EVOO and SO presented a δ and a RI similar to that reported by the standards and researchers with 0.88 and 0.91 g cm− 3 and ≤ 1.467 and 1.470 ≥ respectively. Only SO had a degradation of FA (0.93% oleic acid). When was inducing the adulteration in all concentrations, the δ was modified (0.90 g cm− 3) and RI (1.469 until 1.473), and AI was constant (0.56%). The RI is the best option to be used in the detection of adulteration.
Two Dimensional Volterra Integrodifferential Equation of Heat Conduction and Diffusion Problems and Its Numerical Solutions
Authors: Al-Bugami A. M.
Published: July 2022

This paper deals with new equation in the form Two-dimensional Volterra integrodifferential equation (TDVIDE), which is related of the heat conduction and diffusion problems. Runge–Kutta method (RKM) and Bolck-by-Block method (BBM) have been applied to the problem. Numerical examples are presented, and their results are compared with the analytical solution to demonstrate the validity and applicability of the methods.
Regional neuroinflammation caused by peripheral infection is involved in fatigued symptoms: A [18F]DPA-714 PET study
Authors: Ochi Yuta , Hu Di , Li Danxi , Arakaki Wakiko , Mawatari Aya , Shigeta Mika , Wu Yuping , Hayashinaka Emi , Neyama Hiroyuki , Tahara Tsuyoshi , Wada Yasuhiro , Li Feng , Doi Hisashi , Watanabe Yasuyoshi , Cui Yilong
Published: July 2022

A series of symptoms, including fever, widespread pain, fatigue, and even ageusia, have frequently been reported in the context of various infections, such as COVID-19. Although the pathogenic mechanisms underlying an infection causing fever and pain have been well established, the mechanisms of fatigue induced by infection remain unclear. To elucidate whether and how the peripheral infection cause fatigue via regional neuroinflammation, we performed a brain-wide investigation of neuroinflammation in a peripheral pseudoinfection rat model using [18F]DPA-714 positron emission tomography (PET) imaging analysis, in which the polyriboinosinic: polyribocytidylic acid (poly I:C) was intraperitoneally injected. Consistent with previous reports, transient fever lasting for several hours and subsequent suppression of spontaneous activity lasting a few days were induced by poly I:C treatment. Significant increase in plasma interleukin (IL)-1β, IL-6 and tumour necrosis factor (TNF)-α were observed at 2 and 4 h following poly I:C treatment. PET imaging analysis revealed that the brain uptake of [18F]DPA-714 was significantly increased in several brain regions one day after poly I:C treatment, such as the dorsal raphe (DR), parvicellular part of red nucleus (RPC), A5 and A7 noradrenergic nucleus, compared with the control group. The accumulation of [18F]DPA-714 in the DR, RPC and A5 was positively correlated with the fatigue-like behavior, and that in the A7 tended to positively correlate with fever. These findings suggest that peripheral infection may trigger regional neuroinflammation, which may cause specific symptoms such as fatigue. A similar mechanism might be involved in COVID-19.
Anti-Virus Isoindolinone alkaloids with rare oxocyclopenta[f]isoindole frameworks isolated from the stems of flue cured tobacco
Authors: Hu Qiu-Fen , Ma Yue-Yu , Liu Hua-Yin , Dai Jia-Meng , Yang Feng-Xian , Zhang Jian-Duo , Wang Jin , Li Xue-Mei , Liu Xin , Li Jing , Li Yin-Ke , Wang Wei-Guang , Zhou Min , Yang Guang-Yu
Published: July 2022

Background
The large scale tobacco planting in Yunnan produces a large amount of waste, including stems, roots, low grade and defective tobacco leaves. Therefore, the multipurpose utilization of the by-product of tobacco is an interesting topic. In order to increase medicinal value of tobacco and the comprehensive utilization of its by-products, our group had investigated the chemical constituents of the stems of Y-202, a cultivar of tobacco with high resistance to tobacco mosaic virus (TMV), which originated from K326 by ethylmethane sulfonate (EMS) mutagenesis.
Results
As a result, four new isoindolinone-type small molecule alkaloids named nicoisoindoles A–D (1–4), along with four known isoindole derivatives (5–8) were isolated. Nicoisoindoles A–D represent a new subclass of isoindolinone alkaloids with rare cyclopenta[f]isoindole-1-one frameworks. Among them, nicoisoindole C (3) possesses an unusual N-2-(5-methoxy-6-methylpyridin-2-yl)ethyl moiety, while nicoisoindole D (4) has a novel a N-(3-methyl-6-oxo-1,6-dihydropyridin-2-yl)methyl substituent. Interestingly, compounds 1, 3, and 4 showed high anti-TMV activities with inhibition rates of 43.8, 58.8, and 67.8% at the concentration of 20 µM, and IC50 values of 23.6, 19.5 and 15.4 µM, respectively, even more potent than that of positive control. In order to study whether the oxocyclopenta[f]isoindole-1-ones have more broad antiviral activities, compounds 1–4 were also tested for their anti-rotavirus activities, and they exhibited potential anti-rotavirus activities with therapeutic index (TI) valves in the range of 13.0-18.5.
Conclusions
The successful isolation and structure identification of oxocyclopenta[f]isoindole-1-ones provide materials for the screening of anti-virus activities inhibitors, and also contribute to the development and utilization of the waste from tobacco cultivation.
Analyzing the genome-wide expression of m5C-related regulator genes and prognostic characteristics in pan-cancer
Authors: Zhang Jin , Wang Shuai , Li Guanghao , Duan Yuansheng , Wang Guowen , Zhang Yan
Published: July 2022

Background
It has been reported that 5-methylcytosine (m5C) is involved in DNA/RNA metabolic regulation and has significant implications for cancer diagnosis. M5C-related regulator genes have been reported involved in tumor progression, such as pancreatic adenocarcinomas, low-grade gliomas, and hepatocellular carcinoma, while there have been few studies on the genes in pan-cancers.
Methods
12 m5C-related regulator genes [Y-Box Binding Protein 1 (YBX1), Y-Box Binding Protein 12 (YBX2), NOP2/Sun RNA Methyltransferase 2 (NSUN2), NOP2/Sun RNA Methyltransferase 3 (NSUN3), NOP2/Sun RNA Methyltransferase 4 (NSUN4), NOP2/Sun RNA Methyltransferase 5 (NSUN5), NOP2/Sun RNA Methyltransferase 6 (NSUN6), NOP2/Sun RNA Methyltransferase 27 (NSUN7), DNA Methyltransferase 1 (DNMT1), DNA Methyltransferase 3 Alpha (DNMT3A), DNA Methyltransferase 3 Beta (DNMT3B), tRNA Aspartic Acid Methyltransferase 1 (TRDMT1)] were evaluated for their genomic alterations and clinical relevance across cancers. We performed single nucleotide variations (SNV), copy number variations (CNV), methylation variation, and miRNA-mRNA interactions analysis for patients of 33 cancer types from the Cancer Genome Atlas (TCGA). Based on the Cancer Therapeutics Response Portal (CTRP) and the Genomics of Drug Sensitivity in Cancer (GDSC) database, we assessed the sensitivity of drugs targeting the m5C-related regulator genes.
Results
Several m5C-related regulator genes have undergone significant genetic alterations, and their expression levels are significantly correlated with the activity of cancer hallmark-related pathways. Furthermore, m5C-related regulator genes may serve as used as a prognostic biomarker for cancers. We discovered a number of drugs that may target m5C-related regulator genes by drug sensitivity analysis.
Conclusion
This study revealed the genomic alterations and clinical characteristics of m5C-related regulator genes across 33 cancers, which may clarify the potential mechanism between m5C-related regulator genes and tumorigenesis and provide a novel approach for cancer treatments.
DC Electrical Stimulation effects on N2a and MC3T3 cell lines
Authors: Martín Daniel , Bocio Jesús , Scagliusi Santiago F , Pérez Pablo , Huertas Gloria , Yúfera Alberto , Giner Mercè , Daza Paula
Published: July 2022

Background: Electrical stimulation is a novel tool to promote the differentiation and proliferation of precursor cells. In this work we have studied the effects of direct current (DC) electrical stimulation on neuroblastoma (N2a) and osteoblast (MC3T3) cell lines as a model for nervous and bone tissue regeneration, respectively. We have developed the electronics and encapsulation of a proposed stimulation system and designed a setup and protocol to stimulate cell cultures. Methods: Cell cultures were subjected to several assays to assess the effects of electrical stimulation on them. N2a cells were analyzed using microscope images and an inmunofluorescence assay, differentiated cells were counted and neurites were measured. MC3T3 cells were subjected to an AlamarBlue assay for viability, ALP activity was measured, and a real time PCR was carried out.Results: Our results show that electrically stimulated cells had more tendency to differentiate in both cell lines when compared to non-stimulated cultures, paired with a promotion of neurite growth and polarization in N2a cells and an increase in proliferation in MC3T3 cell line.Conclusions: These results prove the effectiveness of electrical stimulation as a tool for tissue engineering and regenerative medicine, both for neural and bone injuries. Bone progenitor cells submitted to electrical stimulation have a higher tendency to differentiate and proliferate, filling the gaps present in injuries. On the other hand, neuronal progenitor cells differentiate, and their neurites can be polarized to follow the electric field applied.
Intranasal administration of NeuroEPO does not affect the structure of respiratory mucosa in Wistar rats.
Authors: Suárez Ketty , Fernández Gisselle , Cruz Yamila Rodríguez , Seguí Giselle Puldón
Published: July 2022

Introduction:
Diseases associated with the Central Nervous System (CNS) represent a group of conditions with important social and economic repercussions. New treatment strategies with NeuroEPO offer new opportunities to prevent the onset and progression of these disorders. NeuroEPO administered intranasally can reach the CNS through various mechanisms involving the olfactory and trigeminal nerves, respiratory and olfactory mucosa, nasal vasculature, cerebrospinal fluid, and the lymphatic system.
Objective
To determine the effect of intranasal administration of NeuroEPO on the histologic structure of the respiratory mucosa and its associated lymphatic tissue in Wistar rats.
Material and methods
an experimental, descriptive, longitudinal, prospective study was conducted, using the Wistar rat as a biological model. Ten healthy animals were randomly distributed in two groups of five animals each. One of the groups received intranasal NeuroEPO for 28 days at doses of 300 µg/kg. The other group was given a vehicle at a rate of 0.3µl/g. The histological characteristics of the respiratory mucosa were studied. The Mann-Whitney test was used to compare the means
Results
No alterations in the histological characteristics of the respiratory mucosa and the lymphatic tissue associated with the nasal mucosa were observed in Wistar rats after the administration of NeuroEPO.
Conclusion
Intranasal administration of NeuroEPO does not cause pathological changes in the histological structure of the respiratory mucosa or the lymphatic tissue associated with the nasal mucosa of Wistar rats in our experimental conditions.
Recovery of diaphragm function after neuromuscular block by means of diaphragm ultrasonography with comparison of neostigmine vs normal saline as reversal drugs
Authors: Chen Xuejiao , Yang Quanyong , Pan Qian , Zhang Zhenzhen , Yin Yiqing
Published: July 2022

Background
Residual neuromuscular blockade (RNMB) is a well-known risk factor after general anesthesia for critical respiratory events and higher postoperative morbidity. Acetylcholinesterase inhibitors cannot completely avoid RNMB. Neuromuscular monitoring of the adductor pollicis is the gold standard for detecting RNMB, but it cannot be carried out on conscious patients. Ultrasonography of diaphragm excursion may reveal residual effects of neuromuscular blocking agents in conscious patients.
Methods
This prospective, double-blind, single-center randomized controlled study enrolled 150 patients, who belong to ASA physical status I and II, aged 18–65 years, and be scheduled to undergo neuromuscular block with cis-atracurium for neurosurgery. The primary objective will be to compare the difference in DE between groups. Patients will be extubated when the train-of-four ratio is ≥ 0.9. Diaphragm ultrasonography will be used to evaluate the diaphragm excursion. The Diaphragm ultrasonography will be performed before anesthesia induction, at one minute after extubation, and before being discharged from the PACU. The secondary objective was to compare the incidence of postoperative pulmonary complications after operation.
Results
After extubation, the DE of patients was significantly larger in the NEO group than in the NS group (14.14 ± 1.93 vs. 12.96 ± 1.62 mm, P < 0.05). The incidence of RNMB was higher in the NS group, when compared to the NEO group, after extubation (73.33% vs. 53.33%, P = 0.011) and when leaving the PACU (33.33% vs. 20%, P = 0.044). The incidence of respiratory insufficiency after extubation was higher in the NEO group (14.67%), when compared to the NS group (4%) (P = 0.046).
Conclusion
Residual neuromuscular blockade is still a problem to be solved. Diaphragm ultrasound may become a bedside tool in the neuromuscular monitoring field to detect underestimated residual neuromuscular blockade after neuromuscular block.
Trial registration:
The trial was registered prior to patient enrollment at ClinicalTrials.gov (ChiCTR1900021095, Date of registration: January 28, 2019).
Multidisciplinary therapies in the treatment of children with an autism spectrum disorder: a case report
Authors: Ramos Laiene Barbosa , Silva Luana Thaysa da , Godoy Karolline Santos , Souza Rosanea Meneses de , Franco Carla Adriana Souza Oliveira
Published: July 2022

Purpose: To describe multidisciplinary interventions aimed at treating a child diagnosed with an autism spectrum disorder. Case description: The mother sought medical help for her son who exhibited language delays. He was agitated, did not respond to calls, and exhibited a delay in speech development. For psychopharmacological treatment, risperidone 1 mg/mL associated with vitamin D, was prescribed. Multidisciplinary therapies were proposed and applied according to the patient’s needs. In sessions with a speech therapist, he responded to all stimuli, demonstrating good interest in the proposed activities and maintained good eye contact. He performed several circuits to improve posture, image, laterality, and body scheme. After participating in hippotherapy supervised by several professionals, the child exhibited an improvement in social interaction, motor performance, especially in posture practice, and in communication. After interposing equine-assisted therapy with intellectual clinic sessions, he started activities at an inclusive school. Discussion: Multidisciplinary interventions demonstrated effectiveness and continuous and positive evolution in the patient. Studies reporting multidisciplinary therapies are relevant for demonstrating the importance of this method and the adaptation to the reality of each autistic patient.
Reabilitação por prótese ocular em paciente anoftálmico
Authors: Montenegro Victória Aragão , De Mattos Thaysa Cristina Batista , De Assis Rafaela Lima , Leal Cristiane Maria Brasil , Nichthauser Brigitte
Published: July 2022

A perda do glóbulo ocular pode causar danos a autoestima e convívio social de pacientes, além de atresia na musculatura afetada. Este artigo visa relatar a reabilitação por prótese ocular de um paciente anoftálmico. Paciente gênero masculino, 54 anos, procurou o Centro de Especialidades Odontológicas da Universidade do Estado do Amazonas relatando insatisfação estética após perda do globo ocular. Na anamnese relatou que perdeu o globo ocular esquerdo por infecção bacteriana e não tinha problemas sistêmicos que comprometesse o tratamento. Ao exame extra oral foi verificado assimetria facial na região ocular. Iniciou-se a confecção da prótese ocular com moldagem da cavidade utilizando-se alginato. O molde obtido foi incluído em gesso e foi obtido um padrão em cera da cavidade, que foi provado e ajustado no paciente. Foi realizada a pintura da íris protética e esta, foi adicionada ao modelo em cera que foi incluído em mufla com gesso. Após remoção da cera foi adicionado resina acrílica branca termopolimerizável, a mufla foi fechada e prensada. Depois da remoção da prótese em resina da mufla foi realizada a caracterização com pigmentos coloridos e uma nova prensagem, dessa vez com resina acrílica termopolimerizável incolor. Após a presa foi realizado acabamento, polimento e instalação da prótese. Foram realizadas duas sessões de proservação onde o paciente relatou boa adaptação e satisfação com o resultado estético. Concluiu-se que a prótese ocular restabeleceu a estética facial e o suporte palpebral do paciente, proporcionando sua reinserção no convívio social e melhora da autoestima.
Sialodenite Esclerosante Crônica: relato de caso
Authors: Da Silva Letícia Nara Grana Matos , Vieira Myrian Salles , Jorge Araújo de Vasconcelos II Antônio , Pinheiro Tiago Novaes , Cabral Lioney
Published: July 2022

A sialadenite esclerosante crônica foi descrita pela primeira vez na Alemanha por Kuttner, em 1896. É uma lesão benigna semelhante a um tumor que afeta predominantemente a glândula submandibular e é uma doença inflamatória crônica relativamente incomum da glândula salivar. Esta lesão é caracterizada histologicamente por atrofia acinar, fibrose periductal e infiltração de glândulas por linfócitos com formação de folículos linfóides, perda de ácino e, eventualmente, esclerose acentuada da glândula salivar e geralmente ocorre em idosos e adultos de meia idade com ligeira predominância masculina. O relatório descreve um paciente, R.J.R.C, um homem de 53 anos, apresentando um histórico de dois anos de massa sublingual moderada e indolor, relacionada a um edentulismo parcial dos dentes 46 e 47.
Anais 2º Simpósio de Pediatria de Três Lagoas - Pediatria Inclusiva/ LAPED – UFMS – Três Lagoas
Authors: Parduci Natália Varreira , Freitas Alisson Kelvin Pereira Borges , Ricci Raquel Cordeiro , Silva Leonan José de Oliveira e , Ribeiro Isabela Crispim , Cabral Milla Bitencourt , Oda Julie Massayo Maeda
Published: July 2022

Caro (a) Leitor (a),

O 2º Simpósio de Pediatria de Três Lagoas: Pediatria Inclusiva foi realizado nos dias 01, 02 e 05 de junho de 2021. O evento foi organizado pelos membros da Liga Acadêmica de Pediatria da Universidade Federal de Mato Grosso do Sul, Campus de Três Lagoas (UFMS/CPTL), com auxílio de outros discentes e docentes do curso de Medicina da mesma instituição. Em respeito às normas de distanciamento social durante o período de pandemia de COVID-19, o simpósio ocorreu de maneira virtual por meio da transmissão via plataforma de streaming no canal da liga no YouTube. O principal objetivo desse evento foi promover a disseminação do conhecimento baseado em evidências acerca da importância da pediatria inclusiva. Isto é, nossa intenção foi promover uma visão mais humanizada bem como um cuidado integral e multidisciplinar que abarque o máximo possível dos aspectos que circundam as crianças com deficiência, desde os seus primeiros momentos de vida. Para isso, o simpósio contou com a participação, em dois dias,  de profissionais conceituados na área, os quais ministraram palestras na temática de inclusão com uma abordagem multidisciplinar. Junto a isso, houve espaço para a submissão de trabalhos científicos, os quais foram classificados em apresentações do tipo banner ou orais, sendo os melhores premiados com menção honrosa. O Evento foi um sucesso em todos os aspectos. Dessa forma, deixamos aqui nosso agradecimento a todos que colaboraram e participaram!
Osteocondroma em Articulação Temporomandibular: Relato de Caso
Authors: Aires Carolina Chaves Gama , Cavalcanti Thames Bruno Barbosa , Souza Rosa Rayanne Lins de , Viana Ruan de Sousa , Pinto Priscilla Sarmento , Lago Carlos Augusto Pereira do , Vasconcellos Ricardo José de Holanda
Published: July 2022

O osteocondroma é considerado um tumor ósseo benigno que ocorre principalmente em ossos longos, raramente afetando o complexo maxilofacial, porém quando presentes presentes nessa região, tem uma predileção pela mandíbula.coronóide. Geralmente ocorre na faixa etária entre 10 e 30 anos. Quando em côndilo mandibular, podem ocasionar deformidades dento-faciais, resultando em limitação de abertura bucal, maloclusão e assimetria facial. O objetivo do presente trabalho foi relatar o caso de uma paciente do sexo feminino, de 36 anos, encaminhada para a correção de discrepância maxilomandibular, cujos exames complementares evidenciaram a presença de osteocondroma em côndilo mandibular esquerdo. Mediante o quadro optou-se pela ressecção cirúrgica do tumor, através de condilectomia baixa e reanatomização condilar, seguida pelo tratamento ortodôntico pós-operatório. A remoção total da lesão associado a uma reconstrução articular e posterior tratamento ortodôntico foi eficaz em devolver a função articular e a  estética da paciente, visto que houve uma melhora significativa da simetria facial. Após 3 anos, a paciente segue em acompanhamento, sem sinais de recidiva.
Relação entre a Diabetes Mellitus Gestacional e a Doença Periodontal: uma Revisão Atual
Authors: Silveira Karoline Alves , Lima Laís Medeiros Simões de , Dias Caldeira Francois Isnaldo , Pigossi Suzane Cristina , Rodriguez Larissa Santana
Published: July 2022

A doença periodontal (DP) é um processo inflamatório, comum e complexo, caracterizada pela destruição dos tecidos periodontais de suporte, e foi avaliada quanto a um papel potencial no desenvolvimento do diabetes mellitus gestacional (DMG). O objetivo deste trabalho foi realizar um levantamento bibliográfico, sobre a relação entre a  DMG e a DP. Foram realizadas buscas virtuais nas bases de dados PubMed/Medline até junho de 2021, e incluídos os estudos na língua inglesa, publicados nos últimos dez anos. Para tanto foram utilizados os seguintes descritores na língua inglesa: gestational diabetes e periodontal diseases. Dentro desta busca, foram encontrados 71 artigos, dos quais após o processo de triagem, foram excluídos 53 estudos por não responderem a pergunta norteadora. Assim, totalizando 18 pesquisas originais que compuseram esta revisão de literatura narrativa. Os estudos demonstraram que a periodontite atua como fator de risco para o desenvolvimento da DMG, e conhecer os determinantes sociais da saúde envolvidos no processo saúde-doença da doença periodontal, podem ajudar a estabelecer uma ligação entre estas comorbidades que afetam essa parcela da população.
Van Gölü Su Yüzeyi Sıcaklıklarının Eğilim Analizi
Authors: SARACOGLU Kebir Emre , SARACOGLU Fevziye Ayca
Published: July 2022

Bu çalışmada, Van Gölü su yüzeyi sıcaklıklarının değişimi ve eğilimi araştırılmıştır. 2016-2020 tarih aralığı için; NASA-Gündüz, NASA-Gece uydu verileri ile Meteoroloji Genel Müdürlüğü’nden (MGM) 3 istasyon için edinilmiş olan ölçüm verileri karşılaştırılmıştır. Ayrıca gündüz ve gece uzun dönem uydu verilerinin (2001-2020) Theil-Sen ve Yenilikçi Eğilim Analizi yöntemleriyle aylık, yıllık (minimum-ortalama-maksimum) ve mevsimsel eğilim analizleri ile anlamlılık seviyeleri belirlenmiştir. 2016-2020 tarih aralığını kapsayan MGM ölçüm verileri ile NASA-Gündüz/NASA-Gece uydu verilerinin oldukça uyumlu olduğu belirlenmiştir (R=0,94-0,99). NASA-Gece su yüzeyi sıcaklıkları MGM ölçüm verileri ile daha uyumludur. 2001-2020 tarih aralığı için NASA-Gündüz ve NASA-Gece su yüzeyi sıcaklık verilerinin %1 anlamlılık düzeyinde homojen olduğu belirlenmiştir. Hem kısa hem de uzun dönemde su yüzeyi sıcaklıkları artış eğilimindedir. Aylık analizlerdeki en fazla artış (0,094 °C/yıl) gündüz verileri için Haziran ayında, gece verileri için (0,104 °C/yıl) Nisan ayında belirlenmiştir. Mevsimsel analizlerdeki en fazla artış ilkbahar mevsiminde gece verilerinde (0,080-0,099 °C/yıl) tespit edilmiştir. Uzun dönem yıllık ortalama su yüzeyi sıcaklığındaki ortalama artış 0,043 °C/yıl olarak hesaplanmıştır. Bu değerin, Doğu Karadeniz için belirlenmiş olan (0,11 °C/yıl) artıştan daha küçük, Ege ve Doğu Akdeniz için belirlenmiş olandan fazla (0,055°C/yıl), Güney Hazar Denizi için belirlenmiş olan artışın (0,029 ± 0,009 °C /yıl) yaklaşık 1,5 katı ve okyanuslar için belirlenmiş olan artışın (0,011 °C/yıl) yaklaşık 4 katı olduğu sonucuna varılmıştır.
EFFECTS OF SUBSTITUTING FISH MEAL WITH GROUNDNUT CAKE AND INCORPORATING ADANSONIADIGITATA (BAOBAB) AND MORINGAOLIFERALEAVES IN THE FEED OF TILAPIA (OREOCHROMISNILOTICUS L.) DURING THE REARING PHASE IN SENEGAL
Authors:   Animal Production Department of the InstitutSuperieur de Formation AgricoleetRurale (ISFAR) of the UniversiteAliouneDiop de Bambey, Senegal., S.Y Moustapha , Khadre Fall Abdou ,   Animal Production Department of the InstitutSuperieur de Formation AgricoleetRurale (ISFAR) of the UniversiteAliouneDiop de Bambey, Senegal., Dieng Souleymane ,   Department of Animal Production of the EcoleNationaleSuperieurdAgriculture of the University Iba Der Thiam of Thies, Senegal., Niang Awa ,   Department of Animal Production of the EcoleNationaleSuperieurdAgriculture of the University Iba Der Thiam of Thies, Senegal., Dieng Abdoulaye ,   Department of Animal Production of the EcoleNationaleSuperieurdAgriculture of the University Iba Der Thiam of Thies, Senegal.
Published: July 2022

The strong growth of aquaculture in Senegal has led to a significant use of fishmeal, which is becoming rarified and expensive. In order to make the feed accessible to small-scale producers, it became necessary to find a substitute for the fish meal mainly used in fish feeds, due to its high content of balanced proteins. Therefore, three feeds were formulated for rearing fish in comparison to an industrial feed. The study was conducted for 45 days and involved 4 g fry of the species Oreochromisniloticus. They were fed twice a day with iso-protein diets containing 40% PB/MS. Fishmeal was substituted by groundnut meal at doses of 0%, 25%, 50% respectively in the different feeds tested noted R1 R2 and R3. Other ingredients were added such as maize meal, Moringaoliferaleaf and Andansoniadigitata(baobab) leaf. The growth performance of the animals on these three diets was measured and compared to fish fed with the control feed (imported industrial feed noted R4). The average final weights obtained were respectively for the diets R1, R2, R3 and R4 (5.32Â±0.63g, 6.84Â±1.20g, 8.81Â±2.10g, 7.41Â±1.47g). Fish fed the R1 diet had the lowest growth. Fish fed R3 had the best performance with a specific growth rate of 1.96 Â± 0.35 and a feed conversion ratio (FCR) of 1.28 Â± 0.53, compared to a specific growth rate (SGR) of 1.75 Â± 0.44 and a feed conversion ratio of 1.53 Â± 0.34 for fish fed the control diet R4. The latter is comparable to R2 which has a final average weight almost equivalent to R4.
A COMPARATIVE STUDY OF NAVAYASA CHURNA AND NISHA LAUHA IN THE MANAGEMENT OF PANDU W.S.R. TO IRON DEFICIENCY ANAEMIA (IDA)
Authors:   Assi.Prof. Kayachikitsa Dept., Institute of Teaching and Research inAyurveda (ITRA) Institute of National Importance (INI), Ministry of AYUSH, Govt. of India -New Delhi Jamnagar-361008, Gujarat (India)., D. Vyas Hetal , R. Dave Alankruta ,   Asso.Prof. KayachikitsaDept., Institute of Teaching and Research inAyurveda (ITRA) Institute of National Importance (INI), Ministry of AYUSH, Govt. of India -New Delhi Jamnagar-361008, Gujarat (India).
Published: July 2022

Background: Iron deficiency Anaemia is one of the most common nutritional disorder world-wide, especially in India and other developing countries. In Ayurveda, Pandu is considered as a specific disease with its own Pathogenesis and treatment. In modern medicine, there is good treatment for Anaemia with considerable result but that is only for acute deficiencies Anaemias. No significant therapy is there for Chronic Anaemias which occur due to metabolic defects. Navayasachurna and Nisha Lauha both are herbomineralformulations which are effective in GIT disorders and chronic anemias. Materials& Methods: Total 80 Patients were registered of Iron Deficiency Anaemia. 15 patients were left the treatment before completion of therapy. Navayasachurna tablets were given in 33 patients of Group A and Nisha Lauha tablets were given in 32 patients of Group B. Result: Statistically highly significant result was foundinNavayasachurna Group A. Its also improved Hb, S. Iron and S. Ferritin level. So, it is suggested that Navayasachurna is helpful to improve appetite, digestion, clear the obstruction in channels, relieves constipation and increase Rasa- Rakta dhatu and improves Hb level. 21.21 % moderate improvement and 39.39% mild improvement was found in group A. Conclusion:Navayasachurna provided better improvement in Iron Deficiency Anaemia than Nisha Lauha.
A STUDY ON FASTING LIPID PROFILE IN NONADIABETIC STROKE PATIENTS
Authors:   Sri Aurobindo Medical College & PG Institute-Indore (M.P.) India., Pitliya Aakanksha , Vangani Bhavya ,   Sri Aurobindo Medical College & PG Institute-Indore (M.P.) India., Rathore Urvashi ,   MGM Medical College-Indore (M.P.) India., Nathi Aneef Asiff ,   AIIMS Patna-Bihar India., Koruth George Soumya ,   Dr. Somervell Memorial CSI Medical College & Hospital- Thiruvananthapuram India., Padinjarayil Thomas Johnson ,   Dr. Somervell Memorial CSI Medical College & Hospital- Thiruvananthapuram India.
Published: July 2022

Objectives: To study serum fasting lipid profile in patients with acute ischaemic stroke & to determine the significant correlation between them. To assess the role of aggressive control of dyslipidemia on recovery of stroke. Design: Prospective study. Setting: Patients admitted with Ischemic stroke into the Acute Medical Care Unit and Medical Wards in the department of General Medicine, SAIMS Hospital Indore, from December 2019 to November 2021, were taken for the study. Patients were subjected to a Fasting lipid profile at presentation and followed- up at 12 weeks and rechecked the fasting lipid profile and correlated with the recovery of stroke. Participants: A total of 50 Ischaemic stroke patients- 33 males and 17 females, participated. All subjects were above 50 years. Patients with suspected emboli of cardiac origin, haemorrhagic stroke, diabetes and h/o of head injury/usage of anticoagulant drugs were excluded from the study. None of the patients was on diet (or) other modifications to lower plasma lipid levels. Results: S.T.C was abnormal in 11 patients at onset and 8 pts after three months of statin therapy. TG was abnormal in 34 patients at the beginning and 35 pts after three months of treatment. LDL was abnormal in 32 patients at the beginning and 20 pts after three months of statin therapy. HDL was abnormal in 38 patients at onset and 35 pts after three months of treatment. VLDL was abnormal in 34 pts at the beginning & 35 pts after three months of statin therapy. After three months, the MRS score of most of the patients was 0 -1(21 pts), followed by a score of 0 (15 pts). Correlation between mNIHSS score and lipid profile showed a significant clinical improvement with reduction in the LDL levels & the corresponding p- value is .000, which is highly effective. Correlation between MRS score and lipid profile showed a good clinical outcome with a reduction in LDL levels & the corresponding p-value is 0.26, which is substantial. Conclusion: This study shows that higher levels of S.T.C, TG, LDL, VLDL is not the only significant risk factor for the occurrence of ischaemic CVD. A decrease in LDL levels shows significant improvement in clinical outcomes.
SYNTHESIS OF NEWER APPROACH FOR AMIDE CONSISTING DIHYDRO FURAN DERIVATIVES
Authors:   Department of Chemistry, Chaitanya (Deemed to be) university, Telangana State, India., Bhasker Juluru , Velidandi Amarnath ,   Department of Chemistry, Chaitanya (Deemed to be) university, Telangana State, India., Paul J.P. ,   Department of Chemistry, Chaitanya (Deemed to be) university, Telangana State, India., Kandukuri Padma ,   Department of Chemistry, Chaitanya (Deemed to be) university, Telangana State, India.
Published: July 2022

Dihydro furan derivatives are potentially bioactive hence we started working on it prepared them from 2-(4-nitrophenyl)-2-oxoethyl 2-phenylacetate, reducing it and adding substituted carboxylic acids with EDCI, HOBt leads to the titled compounds.
A DESCRIPTIVE STUDY TO ASSESS THE LEVEL OFSATISFACTION ON QUALITY OF NURSING CARE AMONGPATIENTS ADMITTED IN MEDICAL CARE UNITS
Authors: R. Sumi , Mishra Jyoti , Punj Mishra Jyoti , a Jyoti , Gautam Deepika , Khan Farhat , kumar Harsh , Fatima Iffat , Mani Tiwari Kamlesh , Fatima Kaneez , Maurya Kavita
Published: July 2022

Introduction: Increasing competition in every field today also affects the healthcare industry. The most important competitive advantage of health service providers is to provide quality health services The need for increased quality of healthcare services has been identified via healthâ€ related information and advances in technology, changes in expectations and opinions about health care, an increase in individuals involvement in their health care and increased cost and competitiveness in the health sector. Objective: to assess the level of satisfaction on quality of Nursing care among patients. Design: Descriptive cross sectional survey design was chosen to assess the level of satisfaction on quality of nursing care. Participants: The sample size for the study was 60. Nonprobability convenient sampling technique was used to select the sample. Tools : The research toolwas developed in English after an extensive review of expert opinion. The standardized Laschinger PSNCQQ (Patient Satisfaction with Nursing Care Quality Questionnaire) 19 items rating scale consisting of nursing care during hospital stay was used for this study. Results: Among Patients 24(40%) had excellent satisfaction with quality of nursing care and 18(30%) had very good satisfaction with quality of nursing care and 18(30%) good satisfaction withquality of nursing care and no patient had fair and poor levels satisfaction Conclusion: The study was done to assess the level of satisfaction with quality of nursing care among patients. The result of the study shows that most of the patients were satisfied with thequality of nursing care, and there is significant association between level of level of Satisfaction with quality of Nursing care among patients with their selected demographic variables sex and education.
TÜRKÇENİN TARİHÎ METİNLERİNE MODERN BİR BAKIŞ: TONYUKUK YAZITI’NDA “ÖTEKİ” ALGISI
Authors: ATAY Dinçer
Published: July 2022

Orhon Yazıtları Türklük bilgisinin en temel referans kaynaklarıdır. Kendilik bilgisinin gelecekteki nesillere aktarılması kaygısıyla taşa kazınan sözler, dönemin tarihî gelişmelerine ışık tutar. Tonyukuk’un ağzından verilen yazıttaki aidiyet olgularının varlığı, “öteki” algısını da somutlar. “Kendi”nin dışındaki her şey olarak konum alan “öteki”, Tonyukuk Yazıtı’nda da netlik kazanır ve Göktürk devletinin töreli iktidarı adına gerçekleştirilen savaşlarla belirlenir. Nitekim yazar özne konumundaki Tonyukuk, ifadelerinde “öteki”nin kim olduğuna dair net bilgiler verir. Farklı Türk boylarıyla da savaşılmış olması, “yakın öteki” algısını gündeme getirecektir. Türk boylarının kendi aralarındaki mücadeleleri var eden yönetme, erk sahibi olma itkisi, Türkler arasındaki yabancılaşma ve öteki algısını belirleyen bir denklemdir. Metin odaklı söylemde yegâne “ötekilik” referansının “birliğe karşı çıkmak” olduğunu söylenebilir. Nihayetinde Çinliler “düşman öteki”, “büyük öteki”dir. Çalışmada Tonyukuk Yazıtı’nda şekillenen “ötekilik”, Tonyukuk ve Göktürk devleti algısallığında, Göktürk kimliği odağında değerlendirilecektir. Ayrıca “öteki” algısını var eden törel unsurlar ortaya konarak, iktidar - töre denklemi gündeme getirilecektir.
VİYOLA ÖĞRETİMİNDE SOL EL VE SAĞ EL TEKNİKLERİNİN İNCELENMESİ
Authors: TORUN Uğraş
Published: July 2022

Doğru teknik ve müzikal sonuçlara ulaşmak için olması gereken doğru çalgı tekniklerinin sağlıklı bir biçimde uygulanması önem arz etmektedir. Viyolada sol el ve sağ ele ilişkin teknik meseleler, icracının bu hedeflere ulaşmakta kullanacağı temel araçlarıdır. Bu nedenle araştırmanın amacı; viyola öğretiminde sağ el ve sol el tekniklerinin incelenmesi olarak belirlenmiştir. Araştırmada viyola öğretiminde sol el ve sağ el tekniklerini incelemeye yönelik olarak durum tespitine dayalı tarama modeli kullanılmış olup araştırma son yirmi beş yıl içerisinde Google Akademik’te taranan çalışmalarla sınırlı tutulmuştur. Araştırma sonucunda viyola öğretiminde sol el teknikleri ile sağ el tekniklerine yönelik önerilerde bulunulmuştur.
Role of Tyrosine Kinases and their Inhibitors in Cancer Therapy: A
Comprehensive Review
Authors: Kumar Vanktesh , Kaur Navjot , Sahu Sanjeev , Sharma Vikas , Kumar Deepak , Sharma Ajit , Wadhwa Pankaj
Published: July 2022

Recently released Globocan-2020 report has been disclosed an increase in new cancer cases, cancer deaths, and 5-year prevalence cases worldwide. The higher percent proportions of cancer deaths as compared to their incidence percentage in Asia and Africa. Cancer is a genetic but not inheritable disease that consists of various abnormal cells. Depending upon the nature and site of availability of cells cancer can spread all over the body. These abnormal cells can grow infinitely in which tyrosine kinases (TKs) play an important role as mediators for cellular signal transduction processes during migration, metabolism, proliferation and differentiation, apoptotic cell death, etc. TKs belong to a specific family of an enzyme that catalyses the transferring of phosphate groups from ATP to selected tyrosine residues of a target protein during the biological process to maintain the homeostasis. They work in various steps of development and progression pathways of cancer by affecting signal transduction. The aberrant and deregulated functioning of TKs results in a defective signal transduction pathway which leads to abnormality in cell transformation, proliferation, and differentiation, thus the development of cancer. Since their discovery in 1990 to date, more than 90 TKs have been reported and divided into two categories receptor and non-receptor TKs. Higher expression levels of TKs paved their status of oncoprotein and thus, they provide a potential target for the development of anti-cancer therapeutics. Here, we provided updated cancer demographic status, cancer types, and available therapeutic options targeted cancer therapeutic strategies and the role of different TKs in cancers along with recently identified molecules that target TKs. Moreover, we also included the binding interactions of chemical inhibitors with TKs.
The Role of Water Network Chemistry in Proteins: A Structural Bioinformatics Perspective in Drug Discovery and Development
Authors: Sobhia Masilamani Elizabeth , Ghosh Ketan , Kumar Gajjala Siva , Sivangula Srikanth , Laddha Kapil , Kumari Sonia , Kumar Harish
Published: July 2022

Background:

Although water is regarded as a simple molecule, its ability to create hydrogen bonds makes it a highly complex molecule that is crucial to molecular biology. Water mo-lecules are extremely small and are made up of two different types of atoms, each of which plays a particular role in biological processes. Despite substantial research, understanding the hydration chemistry of protein-ligand complexes remains difficult. Researchers are working on harnessing water molecules to solve unsolved challenges due to the development of computer technologies.

Objective:

The goal of this review is to highlight the relevance of water molecules in protein envi-ronments, as well as to demonstrate how the lack of well-resolved crystal structures of proteins fun-ctions as a bottleneck in developing molecules that target critical therapeutic targets. In addition, the purpose of this article is to provide a common platform for researchers to consider numerous as-pects connected to water molecules.

Conclusion:

Considering structure-based drug design, this review will make readers aware of the different aspects related to water molecules. It will provide an amalgamation of information related to the protein environment, linking the thermodynamic fingerprints of water with key therapeutic targets. It also demonstrates that a large number of computational tools are available to study the water network chemistry with the surrounding protein environment. It also emphasizes the need for computational methods in addressing gaps left by a poorly resolved crystallized protein structure.
Host Cell Proteases Mediating SARS-CoV-2 Entry: An Overview
Authors: Oubahmane Mehdi , Hdoufane Ismail , Bjij Imane , Lahcen Nouhaila Ait , Villemin Didier , Daoud Rachid , Allali Achraf El , Cherqaoui Driss
Published: July 2022

The outbreak of the SARS-CoV-2 virus in late 2019 and the spread of the COVID-19 pandemic have caused severe health and socioeconomic damage worldwide. Despite the significant research effort to develop vaccines, antiviral treatments, and repurposed therapeutics to effectively contain the catastrophe, there are no available effective vaccines or antiviral drugs that can limit the threat of the disease, so the infections continue to expand. To date, the search for effective treatment remains a global challenge. Therefore, it is imperative to develop therapeutic strategies to contain the spread of SARS-CoV-2. Like other coronaviruses, SARS-CoV-2 invades and infects human host cells via the attachment of its spike envelope glycoprotein to the human host cell receptor hACE2. Subsequently, several host cell proteases facilitate viral entry via proteolytic cleavage and activation of the S protein. These host cell proteases include type II transmembrane serine proteases (TTSPs), cysteine cathepsins B and L, furin, trypsin, and Factor Xa, among others. Given the critical role of the host cell proteases in coronavirus pathogenesis, their inhibition by small molecules has successfully targeted SARS-CoV-2 in vitro, suggesting that host cell proteases are attractive therapeutic targets for SARS-CoV-2 infection. In this review, we focus on the biochemical properties of host cell proteases that facilitate the entry of SARS-CoV-2, and we highlight therapeutic small molecule candidates that have been proposed through in silico research.