bluuebunny/crossref_metadata_2025 huggingface dataset:
«Maneggiare dalla carità all'economia». Le rendite vitalizie tra previdenza e provvidenza (Italia settentrionale, secoli XVII-­XVIII)
Authors: Dotti Marco
Published: October 2022

L'articolo si focalizza sullo sviluppo delle rendite vitalizie in antico regime, prendendo in considerazione i contratti stipulati da diverse istituzioni caritative nell'Italia settentrionale. Questi strumenti consentivano ai sottoscrittori di impiegare delle risorse (denaro, crediti, immobili) per costituire una pensione a proprio favore e/o a beneficio di terzi, includendo talvolta delle ulteriori prestazioni (esequie, messe pro anima, doti a favore di figlie o nipoti). Le rendite vitalizie costituirono, tra sei e settecento, un caso di studio e un campo di applicazione della nascente probabilità. Lo sviluppo di tali pratiche rappresentò dunque un punto di osservazione privilegiato sui processi di matematizzazione della realtà socio-economica, che consente di osservare la pervasività delle innovazioni, ma anche i fattori di resilienza ravvisabili nella prassi contrattuale. Le fonti suggeriscono che l'introduzione delle tavole di sopravvivenza, pur rendendo in una certa misura prevedibile l'aspettativa di vita dei beneficiari, non assorbiva tutte le loro esigenze e soprattutto non poteva controllare altre incognite, connesse, ad esempio, alla natura e alla qualità del capitale impiegato per costituire le rendite. La molteplicità di istanze sociali impediva, nella maggior parte dei casi, di incasellare i contratti in una griglia precostituita e richiedeva invece una più articolata valutazione contestuale.
Feminidad y neoliberalismo en las series televisivas españolas de éxito durante la crisis económica (2008-2015)
Authors: Gómez-Puertas Lorena , Besaú Casademont Reinald
Published: October 2022

Este artículo evalúa los modelos de subjetividad femenina en las series españolas más vistas en el periodo de crisis económica, como relatos interpretativos de las tensiones ideológicas subyacentes a un contexto donde se replantea el rol de la mujer. El análisis cualitativo, aplicado a diez coprotagonistas de estas ficciones, muestra personajes femeninos carentes de liderazgo y proactividad en la esfera pública, cuyas competencias naturales se circunscriben a la resiliencia para adaptarse a la austeridad sobrevenida, y que actúan como contraposición moral del emprendedor masculino, reactualizando estereotipos de género en el imaginario neoliberal.
Offering 1 - Observations on Field Recording Practice
Authors: Sinha Debashis
Published: October 2022

A video offering a series of text observations on a black screen, responding to a musical work based on a field recording event in Kolkata, India.

Taken from "offering 1: oranges" from the album Quell (https://debsinha.bandcamp.com/album/quell)
Competitive advantages as the basis of a successful organizational strategy
Authors: Kyrych Nataliia , Yuryk Nataliia , Shveda Nataliia
Published: October 2022

In the article the competitive advantages essence of the organization is considered and it stated the advantages presence in a particular area indicates the success of the organization compared to competitors. Competitive advantage can be seen (discovered) in comparing your own organization with competitors. An important and necessary element of the competitive advantage formation and further development is an effective strategy (including competitive) of the organization. In the article, it stated that competitive advantage is an integral part of the organization strategic potential and the basis of organization strong competitive position and determines the nature of its strategy. Today the innovation using is the main tool for achieving competitiveness and competitive advantage of the organization, that allows exploring market opportunities, tries to stand out from similar services of competitors and fill specific market segments. In the article, it defined that the new competitive advantages formation is the most important moment in the organization to achieve a stable competitive position in the market and its own success. Competitive position is a comparative description of the organization main market parameters in modern conditions and its products relative to the competitor. Determining your own competitive position is the first step for competitive analysis and organization’s future strategy development. It is investigated that experts distinguish several degrees of competitive position: dominant, strong, favorable, reliable, weak, and unviable. For an organization that plans its activities and tries to maintain a dominant or strong competitive position, it is proposed to implement the following types of strategy: differentiation strategy; research strategy; customer-oriented strategy; cost minimization; adaptive strategy. In the article, it stated that maintaining a strong position could occur when the company has defeated its rivals by its own unique differences and it is able to maintain these differences in the future. As a basis for success and competitive advantage, each organization is offered to pay strong attention to operational efficiency, ie efficiency with which the company performs better the same activities as its competitors.
Digitalization of accounting processes at small and medium-sized business enterprises
Authors: Spivak Serhii , Gunderuk Tetiana , Hohus Solomiia , Chychun Sofiia
Published: October 2022

The article highlights and analyzes trends in the use of information systems in accounting. The main advantages of using software products in the work of accounting staff are revealed. Transformation of professional skills of an accountant requires from him today not only knowledge of accounting methods, but also the ability to quickly and fully master modern technologies for collecting, processing and exchanging information. The history of development and formation of information systems is investigated. The main reasons for the beginning of the use of software products in enterprises in order to simplify and optimize the accounting process in different areas of accounting are outlined. The essence of the concept of "digitalization" is revealed. The orientation of the company's development strategy on digitalization is a prerequisite for its effective work and increase competitiveness. The authors reviewed software solutions of domestic and foreign developers, as well as among them a number of those that can be used by small and medium enterprises to digitize and simplify accounting. Software products greatly facilitate the process of enterprises and their accounting. Information systems speed up the process of information processing, summarization and storage, which in turn reduces the workload of the specialist. Every accounting program is evolving and improving. Given the recent changes in the country, the market of information systems and technologies has increased many times by domestic developments, which, in turn, compete with foreign software products. The information systems market has become attractive for world-class companies that develop lightweight versions of their own programs, as well as adapt them to the needs of Ukrainian users.
Messenger-marketing as a new level of communication with the client
Authors: Semenіuk Svitlana
Published: October 2022

The article develops the theoretical and methodological principles of messenger marketing, forms its scheme and proposes the main stages for use in the practice of business entities. It is noted that messenger marketing has become a trend in recent years and involves the use of messenger tools to better interact with the target audience to promote the company or its products and services. As a messenger tool, you can consider a wide selection of content that should be sent to users: videos, images, texts, animations, etc. In Ukraine, the most popular messengers are Viber, Facebook Messenger, Skype, Telegram, WhatsApp and others. A messenger marketing scheme has been developed, which includes processes in the sales department, processes in messengers and traffic channels. The processes in the sales departments of the companies are defined, which include the construction of the CRM-system and the payment system, the site and the work of the sales managers. The main processes in messengers - funnels, chatbots and mailings are considered and given a brief description. The main stages for effective use of messenger marketing in practice are proposed, including the choice of messengers for communication with customers, the choice of a platform that will help automate communication, as well as collect data and segment and connect to this platform, integration of messengers with CRM-system. The main tasks of messenger marketing are defined: automation and optimization of managers’ work, which makes it possible to minimize the response time to the application, qualification of potential customers (leads), optimization of advertising costs. The next step in solving this problem should be to reach a new level of communication with customers through messenger marketing. In the future, CRM-marketing is worth to be emphasized, when different channels and CRM-systems work, chatbots are created, which are actively beginning to integrate.
Kriter Ağırlıklandırma Yöntemlerinin ÇKKV Sonuçları Üzerindeki Etkisine Yönelik Gerçek Bir Hayat Uygulaması
Authors: ERSOY Nazlı
Published: October 2022

Bu çalışmada objektif kriter ağırlıklandırma yöntemlerinden Entropy, Criteria Importance Through Intercriteria Correlation (CRITIC), Eşit ağırlık, MEthod based on the Removal Effects of Criteria (MEREC), Standart sapma ve Integrated Data Oriented Weighting System (IDDWS) yaklaşımları kullanılarak, bahsi geçen altı farklı tekniğin Simple Additive Weighting (SAW) Çok Kriterli Karar Verme (ÇKKV) yöntem sonuçları üzerindeki etkisinin incelenmesi amaçlanmıştır. Gerçek bir hayat uygulamasının ele alındığı bu çalışmada, Zorlu Enerji firmasının 2016-2020 dönem aralığı finansal performansının çalışmada önerilen model yardımıyla ölçülmesi amaçlanmıştır. Çalışma sonunda, Entropy, CRITIC, MEREC, Eşit ağırlık, Standart Sapma, IDDWS temelinde SAW yöntemiyle elde edilen sıralama sonuçlarının birbiriyle aynı olduğu tespit edilmiştir. Veri setine yeni alternatifler eklenerek elde edilen sonuçlara göre ise kriter ağırlıklarının sıralama sonuçları üzerinde farklı etkiye sahip olduğu tespit edilmiştir. Bilindiği kadarıyla çalışmada kullanılan teknikler daha önce bir arada kullanılmamıştır. Bu açıdan çalışmanın literatürdeki boşluğu dolduracağı ve literatüre katkı sunacağı düşünülmektedir.
Avaliação da assistência na rede de atenção à saúde para usuário com diabetes
Authors: Brasil Maria de Lourdes Silveira , Schwartz Eda , Cecagno Diana , Lise Fernanda
Published: October 2022

Introdução: A avaliação em saúde é um importante instrumento para a promoção da saúde do usuário com diabetes mellitus. Objetivo: Conhecer as evidências sobre a avaliação da assistência à saúde utilizada no cuidado aos usuários com diabetes mellitus, na Rede de Atenção à Saúde. Métodos: Trata-se de uma revisão integrativa da literatura, realizada de janeiro a junho de 2020, conduzida a partir da questão norteadora: “Quais as evidências sobre avaliação da assistência no cuidado aos usuários com diabetes mellitus na rede de atenção à saúde”. Foram acessadas as bases de dados Scientific Electronic Library Online, Literatura Latino-Americana e do Caribe em Ciências da Saúde e National Library of Medicine, e os descritores Avaliação em saúde; Planos e Programas de Saúde, Diabetes mellitus e Doenças não transmissíveis, conforme protocolo pré-definido. Resultados: Selecionados 22 estudos para análise crítica descritiva. A avaliação de qualidade da assistência à saúde utilizada no cuidado aos usuários com diabetes mellitus, na Rede de Atenção à Saúde foi realizada a partir da tríade estrutura, processo e resultado, apresentados nas categorias “Métodos de avaliação da atenção à saúde” que versou sobre métodos e referenciais teóricos utilizados na avaliação e “Instrumentos de análise da avaliação da atenção à saúde” que abordou as ferramentas usadas pelos profissionais. Conclusão: A análise da produção científica permitiu evidenciar carências nas dimensões estruturais e de organização, nos serviços de saúde, assim como a importância da avaliação em saúde para melhorar a qualidade da assistência ao usuário com diabetes mellitus.
Fatores associados à dermatite em pacientes estomizados
Authors: Silva Fernanda da Mata Vasconcelos , Morato Jéssica Emanuela Mendes , Silva Liniker Scolfild Rodrigues da , Barros Alexsander Wilkard Monte Sales de , Jatobá Joana d’Arc Vila Nova , Ferreira e Pereira Emanuela Batista Ferreira e Pereira
Published: October 2022

Objetivo: Analisar as evidências científicas disponíveis na literatura sobre os fatores associados a dermatite em pacientes estomizados. Métodos: Trata-se de uma revisão integrativa. Realizou-se a busca por artigos, com delimitação nos últimos 5 anos; nos idiomas português, inglês e espanhol; disponíveis na íntegra nas seguintes plataformas de dados: DOAJ, Lilacs, PMC, SCOPUS e Web of Science. Resultados: Os dados foram organizados e apresentados em figuras e tabelas. Dos 1554 estudos encontrados, 224 estavam disponíveis na DOAJ, 5 na Lilacs, 52 na PMC, 444 na Scopus, e 1696 na Web of Science; contudo, após a leitura, permaneceram apenas os que atendiam aos critérios para inclusão e exclusão descritos na metodologia, 5 estudos. Conclusão: Neste estudo evidenciaram-se os fatores associados à dermatite em pacientes estomizados; constando-se que nem sempre estão relacionados diretamente com o estoma, mas com o manuseio do equipamento.
Ressignificação da territorialização na Estratégia Saúde da Família diante do distanciamento social provocado pela COVID-19
Authors: Araújo Andreza Amanda de Araújo , Silva Wanessa Nathally de Santana , Melo Chardsongeicyca Maria Correia da Silva , Silva Kátia Carola Santos , Barros Mariana Boulitreau Siqueira Campos , Monteiro Estela Maria Leite Meirelles , Ó Débora Morgana Soares Oliveira do , Nunes José Ronaldo Vasconcelos
Published: October 2022

Introdução: O novo coronavírus ressignificou os cuidados primários e desafiou as estratégias de territorialização para um atendimento integral e equânime. Objetivo: Compreender, a partir de uma concepção teórica, a ressignificação do território pelos profissionais da Atenção Primária à Saúde em contexto do distanciamento social provocado pela pandemia da COVID-19. Métodos: Trata-se de um estudo descritivo com abordagem qualitativa, realizado com profissionais da Atenção Primária em Saúde, que atuaram no contexto da COVID-19 no ano de 2020. A coleta de dados ocorreu online, mediante formulário elaborado no Google forms contendo questões subjetivas quanto às percepções e experiências sobre o processo de territorialização. Resultados: Percebe-se a reinvenção de novas estratégias de continuidade do cuidado e manutenção do vínculo com a comunidade, evidenciando-se a importância da dimensão sanitária e cultural do território para o processo saúde-doença. Conclusão: O estudo proporciona maneiras distintas de construir o processo de trabalho da atenção primária em tempos de pandemia, na tentativa de continuar garantindo um atendimento sistemático, integral e humanizado para toda a população.
Intranodal Palisaded Myofibroblastoma: A Case Report
Authors: Khaled Ahmed , Alam SM Mahbubul
Published: October 2022

Intranodal palisaded myofibroblastoma is a rare benign soft tissue tumor almost always arising from inguinal lymphnodes. It usually present as a painless, slow growing inguinal mass. We report herein a case of an intranodal palisaded myofibroblastoma occurring in a 43-year-old man along with its salient clinicopathologic features and differential diagnosis.

Pulse volumel.11 January-December 2018-2019 p.19-21
Pellet Embolus in Ulnar artery - A rare vascular Injury
Authors: Nine SMA Zulker , Hossain Mohammad Delwar , Hasan AM Kamrul , Hasan Md Kamrul , Khan Nazmus Sakib , Mehar Tahera , Ahmed Niaz , Haider Md Zulfiqur , Ahmed Sohail
Published: October 2022

Intravascular embolization of bullets and other foreign bodies is a rare complication of penetrating trauma. It can represent a diagnostic challenge because it may present in various and unexpected ways. We report the case of a 65-year-old male who sustained shotgun pellet emboli to left ulnar artery following a right and left upper extremity gunshot injury.

Pulse volumel.11 January-December 2018-2019 p.33-37
Pulse Message Vol 11
Authors: Mahmud Arif
Published: October 2022

Abstract not available

Pulse volumel.11 January-December 2018-2019 p.47
Koulunkäynninohjaajan vastaamattomuus autismikirjon oppilaan sosiaalisiin aloitteisiin
Authors: Kilpiä Anni , Kärnä Eija , Dindar Katja , Räty Hannu
Published: October 2022

Vuorovaikutuskumppanit eivät aina vastaa autismikirjon lasten aloitteisiin. Tässä tutkimuksessa selvitettiin, millaisia päällekkäistyviä vuorovaikutuksellisia projekteja koulunkäynninohjaajalla ja autismikirjon oppilaalla oli silloin, kun ohjaaja ei vastannut oppilaan sosiaaliseen aloitteeseen. Aineistona oli laadullisen sisällönanalyysin keinoin analysoidut videotaltioinnit, jotka koostuivat kolmen autismikirjon oppilaan ja heidän henkilökohtaisten koulunkäynninohjaajiensa vuorovaikutuksesta. Tulosten mukaan lähes puolessa tilanteista vastaamattomuuteen liittyi koulunkäynninohjaajan päällekkäistyvä projekti, joka esti vastaamista tai teki vastaamattomuuden ohjaajan näkökulmasta tarkoituksenmukaiseksi. Aloitteisiin vastaamattomuuden yksilökeskeinen tarkastelu ei ole näin ollen riittävää, koska vastaamattomuutta rakentavat myös vuorovaikutuskumppanin institutionaalinen rooli, kasvatukselliset tavoitteet ja projektien suhde toisiinsa.
Aile Sosyal Destek Programı (ASDEP) Personelinin Risk Altındaki Ailelerin Psikososyal Destek İhtiyaçlarına İlişkin Deneyimleri
Authors: Özpolat Ali Osman , Özkan Yasemin
Published: October 2022

Aile sahip olduğu işlevler nedeniyle her toplum için önemli bir kurum olmuştur ancak küresel ekonomik politikaların da etkisiyle günümüzde sayısız risklere maruz kalmaktadır. Alanda riski ailelerle birebir ve en fazla hane görüşmesi yapan saha çalışanlarından birisi olarak Aile Sosyal Destek Programı (ASDEP) çalışanları ön plana çıkmaktadır. Aynı zamanda Aile ve Sosyal Hizmetler Bakanlığının (ASHB) psikososyal destek konusunda arz odaklı hizmetlerini yürüten ve bu alanda Türkiye’de benzeri bulunmayan bir sosyal hizmet uygulamasıdır. Araştırmamızın temel amacı Türkiye’de risk altındaki ailelerin psikososyal destek ihtiyaçlarına yönelik ASDEP çalışanlarının deneyimlerinden faydalanarak mevcut durumu ortaya koymaktır. Nitel araştırma yönteminin kullanıldığı bu çalışmada fenomenolojik desenden yararlanmıştır. Bu bağlamda araştırma kapsamında her bölgeyi temsil eden en az bir kişi olacak şekilde 6 kadın ve 5 erkek olmak üzere 11 ASDEP görevlisi ile derinlemesine görüşmeler gerçekleştirilerek veriler toplanmıştır. Genellikle ASDEP personelleri; personel yetersizliğinden, iş tanımlarının net olmamasından, iş yoğunluğunun fazlalığından, ASDEP harici işlerde çalıştırıldıklarından, müracaatçı ile güven ilişkisi kurmanın zorluğundan, hizmet içi eğitim yetersizliğinden, ASDEP kapsamında sorulan bazı soruların gereksiz olduğundan, oturmuş bir sistem olmadığından ve arz odaklı hane ziyaretlerinin olumsuzluklarından şikâyet etmektedir. Ayrıca psikososyal desteğin bir görüşmeyle verilmesinin mümkün olmayacağı düşüncesinden hareketle tekrarlı ziyaretlerin önemli olduğu da katılımcılar tarafından vurgulanmıştır.
Toplumsal Cinsiyet Algısı, Anne İstihdam Suçluluğu ve İşten Ayrılma Niyeti İlişkisi: İş-Aile Çatışmasının Rolü
Authors: Bayar Hilal Tuğçe , Yüceer Kardeş Tuba , Özdemir Seyhan , Sever Melih
Published: October 2022

Bu çalışma, aktif iş yaşamında yer alan annelerin toplumsal cinsiyet algısı, anne istihdam suçluluğu ve işten ayrılma niyeti ilişkisinde iş aile çatışmasını incelemek ve literatürde çok fazla üzerinde durulmamış bir konu olan annelik ve istihdam suçluluğu kavramlarını bu perspektiften anlamak amacıyla yapılmıştır. Araştırmada kolayda örneklem yöntemiyle çevrimiçi anket yoluyla 223 çalışan anneden veri toplanmıştır. Elde edilen veriler SPSS26 ve AMOS25 yapısal eşitlik modeliyle analiz edilmiştir. Analizler sonucunda; iş-aile çatışmasının anne istihdam suçluluğunu, anne istihdam suçluluğunun da işten ayrılma niyetini yordadığı görülmektedir. Bu bağlamda kurulan hipotezler doğrultusunda toplumsal cinsiyet algısının iş-aile çatışması aracılığı ile anne istihdam suçluluğunu yordadığı bulunmuştur. Ancak iş-aile çatışmasının anne istihdam suçluluğu vasıtasıyla işten ayrılma niyeti üzerindeki dolaylı etkisinin anlamlı olmadığı tespit edilmiştir.
Gönüllülük Motivasyonları ile Sosyal Girişimcilik Eğilimleri Arasındaki İlişkinin İncelenmesi: Kanonik Korelasyon Analizi
Authors: Açar Erhan , Özcan Nilgün
Published: October 2022

Gönüllülük ile sosyal girişimcilik insan ve toplum yararına faydalı işler yapmayı amaçlayan benzer kavramlardır. Gönüllülük toplumdaki diğer insanlar için hiçbir maddi kazanç gözetmeden yapılan faaliyet olarak tanımlanırken, sosyal girişimcilik ise daha kompleks yapıdaki toplumsal ihtiyaçların giderilmesi amacıyla girişimci fikirler ve uygulamalarla sosyal değer yaratmayı amaçlamaktadır. Bu çalışmada gönüllülük faaliyetlerinde bulunan 15-29 yaş arasındaki gençlerin, gönüllülük motivasyonları ile sosyal girişimcilik eğilimleri arasındaki ilişki kanonik korelasyon analizi ile incelenmiştir. Analiz sonucunda gönüllülük motivasyonları ile sosyal girişimcilik eğilimleri arasında pozitif yönlü ve istatistiksel olarak anlamlı bir ilişki tespit edilmiştir.
EXPLORING THE EXPERIENCES AND THE LIVING CONDITIONS 0-6 YEARS OLD CHILDREN CO-RESIDING WITH THEIR INCARCERATED MOTHERS IN WOMEN'S PRISON FROM THE MOTHERS' PERSPECTIVE
Authors: Çengeköylü Ceyda , Bademci Özden , Çelik Dilek , Karadayı Esma Figen
Published: October 2022

It is known that during early childhood the traumatic living conditions and experiences of children who stay in the prison with their mothers have lasting effects on the development of children. A psychosocial intervention program was implemented in seven womens’ prisons in Turkey by a non-governmental organization in order to support mothers’ relationships with their children between the ages of 0-6 whom stayed with them in prison. The qualitative data of the research consists of the phenomenological analysis of the documents containing the written records of the mothers' narratives during the group sharings carried out with 68 mothers and 70 children. As a result of the analyzes, the themes of "the traumatic physical conditions and socio-cultural environment of the prison for children", "being a mother in prison: guilt, inadequacy", "growing up in prison conditions" and "vicious circle of transgenerational violence" passed from mothers to their children have been reached. The narratives of mothers clearly reveal the traumatic physical and social conditions of prisons and the negative effects of these conditions on the development of children. The results of the research draw attention to the necessity of urgently addressing the conditions of children staying with their mothers in prisons, making a comprehensive individual assessment for each child, taking into account the best interests of the child, and preferring detention measures or different practices for pregnant women and those who have children.
Genetic structure and origin of non-native, free-living Atlantic salmon Salmo salar along a latitudinal gradient in Chile, South America
Authors: Marín-Nahuelpi R , Yáñez JM , Musleh SS , Cañas-Rojas D , Quintanilla JC , Contreras-Lynch S , Gajardo G , Sepúlveda M , Harrod C , Gomez-Uchida D
Published: October 2022

Limited stocking efforts to introduce Atlantic salmon Salmo salar into Chilean rivers and streams were unsuccessful during the 20th century. Following the arrival of the aquaculture industry during the 1980s, escaped Atlantic salmon have presented an ecological risk to native taxa through predation, competition, and transmission of pathogens or parasites. However, whether commercial aquaculture strains represent the likely source of free-living Atlantic salmon in marine and freshwater environments is unclear. We used 272 single nucleotide polymorphisms to characterize free-living Atlantic salmon (n = 80) captured from 12 marine and freshwater locations in southern Chile. These were compared with 8 reference collections, 6 known commercial strains, and 2 wild populations of Atlantic salmon. We evaluated genetic structure among free-living Atlantic salmon and assessed individual ancestry and origin by assigning mixture samples to reference collections. We found evidence for genetic structure (number of clusters, K = 3) among free-living salmon unexplained by geography, environment, or life stage, but consistent with the number of clusters among commercial aquaculture strains. Most free-living Atlantic salmon had a close ancestry with farmed Norwegian strains, the most widely used by the industry, pointing to recent aquaculture escapes as their origin. Yet recent establishment of self-sustaining populations weakly differentiated from aquaculture broodstock cannot be ruled out. We propose increasing monitoring efforts of free-living Atlantic salmon in remote sites as well as in watersheds located in densely stocked aquaculture areas.
Transcatheter Options for Treatment of Mitral Regurgitation
Authors: Schaefer Schaefer , Treede Hendrik , Reichenspurner Hermann , Conradi Lenard
Published: October 2022

Transcatheter therapy for valvular heart disease (VHD) as an alternative for surgery, as the standard of care, has emerged rapidly over the last 10 years. Since the first transcatheter heart valve (THV) implantation in pulmonary position, in 2000, and in aortic position, in 2002, an enormous number of high-risk patients have undergone percutaneous aortic valve implantation and a wide variety of commercially available THVs have emerged within the medical sector. Interventional mitral valve repair (MVR) and implantation started with a variety of devices developed by industry, but few are available at the moment. In this article percutaneous systems for the treatment of mitral regurgitation (MR) in high-risk patients are introduced and discussed. Technologies currently under development can be classified by their anatomical approach. To date, only the percutaneous edge-to-edge approach is applied on a larger scale in clinical routine with the MitraClip device. Several other technologies for percutaneous MVR have achieved first-in-man results. For comparable results of transcatheter MVR to surgical MVR a combination of these technologies may be required. The field of transcatheter mitral valve implantation is evolving quickly as well. With half a dozen devices under development right now and a few entering the clinical test stage it may be just a matter of time until a THV for the mitral position will become commercially available. Considering that MR is among the most frequent entities in VHD and, furthermore, that life expectancy will continue to increase, it can be anticipated that in the near future there will be percutaneous strategies needed for the treatment of MR in high-risk patients. At present, all devices have to be restricted to inoperable patients or to compassionate use settings. However, once clinical proof of safety and efficacy have been demonstrated, extension to a broader patient spectrum seems likely. To ensure cautious and safe clinical introduction of these novel therapeutic options, guidance by interdisciplinary dedicated heart teams is of paramount importance.
Hospital Service Quality and Patients’ satisfaction within Soddo Christian Hospital PLC, Walaitta Region, Southwestern Ethiopia
Authors: Providence Sibomana , Cissy Karungi , Sylvestre Munyengabe
Published: October 2022

In this paper about Hospital service quality and patient satisfaction have been considered as significant factors for any Hospital that is looking forward to succeed, the research tested a service quality model SERVQUAL to measure patient’s satisfaction with the delivery of service. Five main dimensions of the service quality model SERVQUAL which were applied are tangibility, reliability, responsiveness, assurance and empathy. The model was applied to the customers who had previous experience from Soddo Christian Hospital. The purpose of this paper was to investigate the factors that contribute to customer satisfaction at Soddo Christian Hospital. The study helps to examine and understand the factors influenced in determining customer satisfaction. Usable samples of 250 questionnaires were collected out of 302 that were distributed to the patients. SPSS software was used to do reliability analysis and regression analysis. The findings showed that there is a significant relationship between contextual factors and customer satisfaction as the correlation coefficient of 0.730 indicate high correlation between responsiveness dimension and customer satisfaction. The analysis indicated that responsiveness of perceived quality have direct relationship with customer satisfaction compared to other contextual factors. Furthermore, this paper reports that customer satisfaction depend on service quality as there is statistical significance of the predictor hospital service quality (F5, 225= 52.395 and p<.000), has probability occurrence of by chance only of less than 0.001) this confirms that, there is statistical significance at 1% level between hospital service and patient satisfaction.

There is moderate positive significant relationship with patient satisfaction as the perceived correlations of four dimensions are: Tangibility (r = .635), Reliability (.r = .645), Assurance (r = .620) and Empathy (r = .622) respectively.
Quality of information in YouTube videos on prostate fusion biopsy
Authors: Aydogan Tahsin Batuhan
Published: October 2022

Objective: The aim of this study is to evaluate the quality of videos on YouTube related to MRI-TRUS prostate fusion biopsy.  Material and Methods: A YouTube search was made on March 16, 2022, for the videos related to “MRI-TRUS prostate fusion biopsy”. The first 70 videos were ranked during this study by choosing “relevance” as a criterion. Video content quality was evaluated using the internationally validated Journal of the American Medical Association Benchmark Score (JAMAS) and Global Quality Score (GQS). The researcher also developed MRI-TRUS Prostate Fusion Biopsy Scoring (MTPFBS) to evaluate videos’ technical content. The upload origin and length of video view count, like and dislike ratios, and video power indexes (VPI) were all evaluated.  Results: Video content from academic center sources had significantly higher GQS scores than scientific meetings or private institution videos. Video content prepared by private institution sources had significantly lower MTPFBS and JAMA scores than other videos (p<0.05). According to the type of information, videos uploaded with voice and writing had significantly higher JAMAS and MTPFBS than voice alone (p<0.05). The length of videos showed a positive correlation with JAMA and MTPFBS. VPI and the number of likes showed a strong correlation. However, VPI or the number of likes did not correlate with GQS, JAMAS, and MTPFBS scores.  Conclusion: Evaluated on YouTube, the MRI-TRUS prostate fusion biopsy videos were low quality. In that regard, videos prepared by specialists and academic centers should be standardized to transfer better quality information. According to current data, watching these video contents may not be recommended. Keywords: Multiparametric magnetic resonance imaging; prostate; internet
The efficacy of regional analgesia techniques in urological robotic surgeries: a retrospective clinical study
Authors: Coşarcan Sami Kaan , Doğan Alper Tunga , Kılıç Mert , Erçelen Ömür
Published: October 2022

Objective: The advantages of robot-assisted surgery include shorter incisions, less postoperative pain, perioperative blood loss, and a faster return to daily functions. Thoracic epidural analgesia (TEA) provides highly satisfactory analgesia in abdominal surgery. However, its hypotensive effect, particularly in minimally invasive procedures, exceeds its contribution to rapid recovery. Fascial plane blocks may be more beneficial in that context. This study evaluated the effects of regional analgesia techniques in robotic prostatectomy, nephrectomy, and cystectomy operations. Material and Methods: Following IRB Ethics Committee approval (2021.467.IRB1.134), the records of patients who had undergone robotic prostatectomy, nephrectomy, and cystectomy surgeries were retrospectively reviewed between January 2018 and January 2022.  Results: One hundred and forty patients with full documentation were included in this study. Various regional analgesia methods were used. Fascial plane blocks were seen to be used in addition to epidural analgesia. Transversus abdominis plane (TAP) and rectus sheath blocks exhibited satisfactory results in robotic prostate surgeries and TAP blocks in robotic nephrectomy operations. Conclusion: In robotic prostatectomy and nephrectomy operations, we recommend fascial plane blocks as the first-choice method for postoperative analgesia. Keywords: regional anesthesia, robotic surgery, radical prostatectomy, minimally invasive surgery, fascial plane blocks, recovery after surgery
On Time Irreversibility of Generalized Hassani Kinematics
Authors: Grushka Yaroslav
Published: October 2022

The original Hassani transforms were introduced in the works of Algerian physicist M.E. Hassani. Hassani's generalized (superluminal) kinematics appeared in the cohntext of generalization and development of Hassani's ideas. In the present paper, applying Theorem of non returning for universal kinematics, it is proven that Hassani's generalized kinematics with positive direction of time are certainly time irreversible. From the physical point of view the last result means that in any time-positive Hassani kinematics temporal paradoxes are impossible basically, that is there is not potential possibility to affect the own past by means of "traveling" and "jumping" between reference frames.
The single-atom iron nanozyme mimicking peroxidase remodels energy metabolism and tumor immune landscape for synergistic chemodynamic therapy and photothermal therapy of triple-negative breast cancer
Authors: Qian Xiaojun , Shi Ronghua , Chen Jian , Wang Yong , Han Xinghua , Sun Yubei , Ling Cong , Wang Gang , Xu An-Wu , Pan Yueyin
Published: October 2022

Chemotherapy, as one main strategy to relieve tumor progression, has a weak effect on triple-negative breast cancer (TNBC) chest wall metastasis. The development of near-infrared (NIR) light-responsive nanomaterials for chemodynamic therapy (CDT) and photothermal therapy (PTT) is a promising platform but still challenging in biomedicine. This study reports a peroxidase mimicking nanozyme (Fe-N-C SAzyme) against TNBC by CDT and PTT. Fe-N-C SAzyme generated reactive oxygen species (ROS) by decomposing H2O2 into hydroxyl radicals (•OH) and also induced light-to-heat conversion under the exposure of 808 nm laser irradiation. With these biological characteristics, the obtained Fe-N-C SAzymes displayed enhanced cell cytotoxicity and inhibition of cancer cell proliferation both in vitro and in vivo at a low dose of nanoagent and a moderate NIR laser power density. Besides, Fe-N-C nanoagent with its excellent ROS generation brought metabolic reprogramming of elevated glycolysis in tumor cells. In vivo experiments, when combined with PTT, the enhanced antitumor effect was found by the elimination of M-MDSC in tumor microenvironment. Fe-N-C SAzymes can serve as a new synergistic CDT and PTT nanoagent to simultaneously reprogram tumor metabolism and tumor microenvironment. It will provide prospects for chemodynamic/photothermal combined cancer therapy for TNBC chest wall metastasis based on the use of a single nanosystem.
Engineered nanomaterials trigger abscopal effect in immunotherapy of metastatic cancers
Authors: Xia Yuanliang , Yang Ruohan , Zhu Jianshu , Wang Hengyi , Li Yuehong , Fan Jiawei , Fu Changfeng
Published: October 2022

Despite advances in cancer treatment, metastatic cancer is still the main cause of death in cancer patients. At present, the treatment of metastatic cancer is limited to palliative care. The abscopal effect is a rare phenomenon in which shrinkage of metastatic tumors occurs simultaneously with the shrinkage of a tumor receiving localized treatment, such as local radiotherapy or immunotherapy. Immunotherapy shows promise for cancer treatment, but it also leads to consequences such as low responsiveness and immune-related adverse events. As a promising target-based approach, intravenous or intratumoral injection of nanomaterials provides new opportunities for improving cancer immunotherapy. Chemically modified nanomaterials may be able to trigger the abscopal effect by regulating immune cells. This review discusses the use of nanomaterials in killing metastatic tumor cells through the regulation of immune cells and the prospects of such nanomaterials for clinical use.
Comparison of early osseointegration of non-thermal atmospheric plasma-functionalized/ SLActive titanium implant surfaces in beagle dogs
Authors: Long Li , Zhang Min , Gan Shuaiqi , Zheng Zheng , He Yanjin , Xu Jia , Fu Ruijie , Guo Qiang , Yu Deping , Chen Wenchuan
Published: October 2022

Background: Hydrophilic dental implants are gaining increasing interest for their ability to accelerate bone formation. However, commercially available hydrophilic implants, such as SLActive™, have some major limitations due to their time-dependent biological aging and lower cost-effectiveness. The non-thermal atmospheric plasma (NTAP) treatment is a reliable way to gain a hydrophilic surface and enhance osseointegration. However, a few studies have been carried out to compare the osseointegration of NTAP-functionalized titanium implants and commercially available hydrophilic implants.

Purpose: In this study, we compare the osseointegration abilities of the NTAP-functionalized titanium implant and Straumann SLActive.

Material and methods: The NTAP effectiveness was examined using in vitro cell experiments. Then, six beagle dogs were included in the in vivo experiment. Straumann SLActive implants, SLA implants, and SLA implants treated with NTAP were implanted in the mandibular premolar area of dogs. After 2 w, 4 w, and 8 w, the animals were sacrificed and specimens were collected. Radiographic and histological analyses were used to measure osseointegration.

Results: NTAP treatment accelerated the initial attachment and differentiation of MC3T3-E1 cells. In the in vivo experiment, bone parameters (e.g., BIC value and BV/TV) and volume of new bone of NTAP groups were close to those of the SLActive group. Additionally, although there was no statistical difference, the osseointegration of SLActive and NTAP groups was evidently superior to that of the SLA group.

Conclusion: NTAP-functionalized implants enhanced cell interaction with material and subsequent bone formation. The osseointegration of the NTAP-functionalized implant was comparable to that of the SLActive implant at the early osseointegration stage.
Wrack placement to augment constructed dunes: A field investigation
Authors: Provost Leigh A. , Eisemann Eve R. , Anderson Carlton P. , Waldron Margaret C. B.
Published: October 2022

Natural and nature-based features have become increasingly popular in recent years for several reasons including reduced costs and maintenance, sustainability, and ecological benefits. One such nature-based feature which contributes to coastal resiliency is dune systems. Extensive research shows that dune systems provide great value for coastal protection, with vegetation and belowground biomass emerging as crucial factors for dune stability. Alternative dune construction and dune maintenance methods are needed to improve the resilience and stability of these dune systems. Wrack, vegetation and macroalgae that naturally washes up along the coast, is often removed during routine beach maintenance, but could serve to increase dune biomass, sand trapping, and overall dune resiliency. This manuscript documents preliminary results following the placement of wrack along constructed dunes on the Mississippi mainland coast. Terrestrial lidar surveys were used to evaluate morphological responses of a 550 m stretch of the beach, with varying raking and wrack management practices implemented in designated sections. Elevation and volumetric change calculated from these data were compared across storm erosion and fair-weather recovery periods to quantify the potential benefits of utilizing natural wrack material in the dunes and reducing beach raking.
The concept of tissue regeneration: Epistemological and historical enquiry from early ideas on the regeneration of bone to the microscopic observations of the regeneration of peripheral nerves
Authors: Barbara Jean-Gaël
Published: October 2022

This paper examines the epistemological history of physiological tissue regeneration theories from Antiquity to the present time focusing on early clinical observations, microscopic investigations of the 19th C. and molecular aspects of the regeneration of peripheral nerves. We aim to show underlying theoretical implications at stake over centuries, with an extreme diversity of local contexts, while slowly emerging ideas were progressively built in the framework of cell theory and that of molecular biology. The overall epistemological lesson is that this long history is far from finished and requires novel experiments and perspectives, as well as the careful inspection of its rich past, as a true scientific tradition, in order to better understand what is nervous regeneration and how we can use it in medicine.
Sodium butyrate in both prevention and supportive treatment of colorectal cancer
Authors: Kaźmierczak-Siedlecka Karolina , Marano Luigi , Merola Elvira , Roviello Franco , Połom Karol
Published: October 2022

Accumulating evidence suggests that selected microbiota-derived metabolites play a significant role in both tumor prevention and supportive treatment of cancer. Short-chain fatty acids (SCFAs), i.e., mainly acetate, proprionate, and butyrate, are one of them. Nowadays, it is known that butyrate is a key microbial metabolite. Therefore, in the current review, we focused on butyrate and sodium butyrate (NaB) in the context of colorectal cancer. Notably, butyrate is characterized by a wide range of beneficial properties/activities. Among others, it influences the function of the immune system, maintains intestinal barrier integrity, positively affects the efficiency of anti-cancer treatment, and may reduce the risk of mucositis induced by chemotherapy. Taking into consideration these facts, we analyzed NaB (which is a salt of butyric acid) and its impact on gut microbiota as well as anti-tumor activity by describing molecular mechanisms. Overall, NaB is available as, for instance, food with special medical purposes (depending on the country’s regulation), and its administration seems to be a promising option for colorectal cancer patients.
Nano drugs delivery system: A novel promise for the treatment of atrial fibrillation
Authors: Wang Zhengjie , Tong Qi , Li Tao , Qian Yongjun
Published: October 2022

Atrial fibrillation (AF) is one of the most common sustained tachyarrhythmias worldwide, and its prevalence is positively correlated with aging. AF not only significantly reduces the quality of life of patients but also causes a series of complications, such as thromboembolism, stroke, and heart failure, increases the average number of hospitalizations of patients, and places a huge economic burden on patients and society. Traditional drug therapy and ablation have unsatisfactory success rates, high recurrence rates, and the risk of serious complications. Surgical treatment is highly traumatic. The nano drug delivery system has unique physical and chemical properties, and in the application of AF treatment, whether it is used to assist in enhancing the ablation effect or for targeted therapy, it provides a safer, more effective and more economical treatment strategy.
Case report: Multimodal imaging diagnosis of a giant coronary artery fistula: A report of two cases
Authors: Sharifkazemi Mohammadbagher , Mohseni-Badalabadi Reza , Hosseinsabet Ali , Hajizeinali Alimohammad
Published: October 2022

Being a very rare cardiac disease, most cases of coronary artery fistula (CAF) are genetic. Complications such as coronary steal syndrome, myocardial infarction, heart failure, or tamponade can manifest following the abnormal communication that the fistula creates between the coronary arteries and cardiac chambers or major vessels and the subsequent shunt. Most CAFs are small and asymptomatic, making diagnosis difficult. In symptomatic patients, the initial diagnostic workup is generally made with chest radiography and electrocardiography. Other imaging modalities have also been suggested to improve diagnostic accuracy. Cardiac catheterization and coronary angiography are currently the gold standard for diagnosis and planning the intervention, as they can recognize the quantum of the shunt as well as complications of a fistulous track (e.g., aneurysm formation, thrombus, leak, and the number of openings to the receiving chamber/vessel); however, this invasive method may be associated with risk. Herein, we report two patients with giant CAFs, one from the left circumflex artery to the coronary sinus and the other to the superior vena cava. Moreover, we describe how multimodal imaging, including two- and three-dimensional transesophageal echocardiography, coronary cineangiography, coronary computed tomography angiography, and enhanced chest computed tomography, can facilitate diagnosis and estimate the disease course in such patients. We believe that using multimodal imaging cannot only help the initial diagnosis regarding the presence of a CAF and the accurate anatomical site of the fistula in the patient but can also help predict the disease course and choose the most suitable treatment modality. Therefore, we suggest multimodal imaging be done to diagnose patients suspected of CAF. However, invasive cineangiography should be necessarily followed, regardless of whether an intervention is planned or not.