bluuebunny/crossref_metadata_2025 huggingface dataset:
Time-lapse acoustic impedance variations during CO2 injection in Weyburn oilfield, Canada
Authors: Wang Yichuan , Morozov Igor B.
Published: October 2019

For seismic monitoring injected fluids during enhanced oil recovery or geologic [Formula: see text] sequestration, it is useful to measure time-lapse (TL) variations of acoustic impedance (AI). AI gives direct connections to the mechanical and fluid-related properties of the reservoir or [Formula: see text] storage site; however, evaluation of its subtle TL variations is complicated by the low-frequency and scaling uncertainties of this attribute. We have developed three enhancements of TL AI analysis to resolve these issues. First, following waveform calibration (cross-equalization) of the monitor seismic data sets to the baseline one, the reflectivity difference was evaluated from the attributes measured during the calibration. Second, a robust approach to AI inversion was applied to the baseline data set, based on calibration of the records by using the well-log data and spatially variant stacking and interval velocities derived during seismic data processing. This inversion method is straightforward and does not require subjective selections of parameterization and regularization schemes. Unlike joint or statistical inverse approaches, this method does not require prior models and produces accurate fitting of the observed reflectivity. Third, the TL AI difference is obtained directly from the baseline AI and reflectivity difference but without the uncertainty-prone subtraction of AI volumes from different seismic vintages. The above approaches are applied to TL data sets from the Weyburn [Formula: see text] sequestration project in southern Saskatchewan, Canada. High-quality baseline and TL AI-difference volumes are obtained. TL variations within the reservoir zone are observed in the calibration time-shift, reflectivity-difference, and AI-difference images, which are interpreted as being related to the [Formula: see text] injection.
Levonorgestrel Inhibits Embryo Attachment by Eliminating Uterine Induction of Leukemia Inhibitory Factor
Authors: Matsuo Mitsunori , Hirota Yasushi , Fukui Yamato , Fujita Hidetoshi , Saito-Fujita Tomoko , Kaku Tetsuaki , Gebril Mona , Hirata Tomoyuki , Akaeda Shun , Hiraoka Takehiro , Tanaka Tomoki , Haraguchi Hirofumi , Saito-Kanatani Mayuko , Shimizu-Hirota Ryoko , Takeda Norihiko , Fujii Tomoyuki , Osuga Yutaka
Published: October 2019

Progestogens including progesterone (P4) and levonorgestrel (LNG) are clinically used for multiple purposes such as contraception and infertility treatment. The effects of progestogens on the uterus remains to be elucidated. Here we examine the effect of excessive progestogen administration on embryo implantation focusing on the function of uterine leukemia inhibitory factor (LIF), a cytokine that is induced by estrogen and essential for embryo attachment. Treatment of wild-type (WT) female mice with vehicle (control), LNG at the dose of 300 μg/kg/day and P4 at the dose of 10 mg/day from day 1 to day 4 of pregnancy was conducted. LNG-treated and P4-treated mice showed embryo attachment failure on day 5 of pregnancy (The rate of mice with embryo attachment sites [%MAS], 11% and 13%, respectively), while all the control mice had normal attachment sites. Uterine LIF expression was significantly reduced in LNG-treated and P4-treated mice on day 4 evening. Administration of recombinant LIF (rLIF) at the dose of 24 μg/day on day 4 significantly rescued embryo attachment failure in LNG-treated and P4-treated mice (%MAS, 80% and 75%, respectively). Estradiol (E2) administration also rescued embryo attachment failure in LNG-treated mice (%MAS, 83%). Furthermore, excess P4 treatment before implantation decreased decidual P4 receptor (PGR) expression and induced decidualization defect apart from LIF downregulation. These findings indicate that progestogens cause embryo attachment inhibition through downregulation of uterine LIF expression and compromised decidualization through downregulation of PGR independently of LIF reduction. This study may contribute to a better understanding of contraceptive action of progestogens.
Brown Adipose Crosstalk in Tissue Plasticity and Human Metabolism
Authors: Scheele Camilla , Wolfrum Christian
Published: October 2019

Infants rely on brown adipose tissue (BAT) as a primary source of thermogenesis. In some adult humans, residuals of brown adipose tissue are adjacent to the central nervous system and acute activation increases metabolic rate. Brown adipose tissue (BAT) recruitment occurs during cold acclimation and includes secretion of factors, known as batokines, which target several different cell types within BAT, and promote adipogenesis, angiogenesis, immune cell interactions, and neurite outgrowth. All these processes seem to act in concert to promote an adapted BAT. Recent studies have also provided exciting data on whole body metabolic regulation with a broad spectrum of mechanisms involving BAT crosstalk with liver, skeletal muscle, and gut as well as the central nervous system. These widespread interactions might reflect the property of BAT of switching between an active thermogenic state where energy is highly consumed and drained from the circulation, and the passive thermoneutral state, where energy consumption is turned off. (Endocrine Reviews 41: XXX – XXX, 2020)
Autophagy-related Djatg8 is required for remodeling in planarians Dugesia japonica
Authors: Kang Jing , Dong Zimei , Wang Jing , Chen Guangwen , Liu Dezeng
Published: October 2019

Planarian is the earliest free-living platyhelminthe with triploblastic and bilateral-symmetry. As an integral component of tissue homeostasis and regeneration, remodeling occurs constantly in the general planarian's life history. In present study, we isolate three planarian Dugesia japonica Atg8 genes (Djatg8-1, Djatg8-2, Djatg8-3) that show high sequence similarity with Atg8 from yeast and human. Results from the whole-mount in situ hybridization indicate that Djatg8-2 and Djatg8-3 are strongly expressed in the blastmas during Dugesia japonica regenerating. Using RNA interference, inhibition of Djatg8-1 gene expression has no obvious effect on planarians morphological changes. Interestingly, down-regulation of Djatg8-2 gene expression in planarians results in defects in the blastema regeneration and tissue regression. Furthermore, loss of Djatg8-3 expression leads to tissue degradation. Taking together, our results suggested that Djatg8-2 and Djatg8-3 play important roles in the planarian remodeling during regeneration.
Desmoplastic small round cell tumour in the Afro-Caribbean population: case report with imaging findings
Authors: Francis Kino Ceon , South Chevar O’Shay , Williams Bonnie-Paul Regis , Gabriel Kurt Garey , Bromfield Mahiri
Published: October 2019

Desmoplastic Small Round Cell Tumour (DSRCT) is a rare malignancy that has only a few cases documented in the literature. We report a case of DSRCT in the abdomen and pelvis that was identified following ultrasound-guided biopsy of one of the numerous liver lesions seen on imaging in a 13-year-old Afro-Caribbean female with increased abdominal girth. The tumour was characterized by all routine imaging modalities available at the time. To our knowledge, this is the first reported and published case in the English speaking Caribbean. In the review of the literature, we correlate the imaging findings with previously reported cases. The diagnosis of DSRCT cannot be made solely using standard imaging techniques, but radiologists should be suspicious of DSRCT as a differential diagnosis in a young patient with increased abdominal girth, multiple liver and peritoneal deposits seen on imaging. Written informed consent for the case to be published (incl. images, case history, and data) was obtained from the parents of this patient for publication of this case report, including accompanying images.
A study protocol for a randomised crossover study evaluating the effect of diets differing in carbohydrate quality on ileal content and appetite regulation in healthy humans
Authors: Byrne Claire S. , Blunt Dominic , Burn James , Chambers Edward , Dagbasi Aygul , Franco Becker Georgia , Gibson Glenn , Mendoza Lilian , Murphy Kevin , Poveda Carlos , Ramgulam Anya , Tashkova Martina , Walton Gemma , Washirasaksiri Chaiwat , Frost Gary
Published: October 2019

Introduction: A major component of the digesta reaching the colon from the distal ileum is carbohydrate. This carbohydrate is subject to microbial fermentation and can radically change bacterial populations in the colon and the metabolites they produce, particularly short-chain fatty acids (SCFA). However, very little is currently known about the forms and levels of carbohydrate in the ileum and the composition of the ileal microbiota in humans. Most of our current understanding of carbohydrate that is not absorbed by the small intestine comes from ileostomy models, which may not reflect the physiology of an intact gastrointestinal tract.

Methods: We will investigate how ileal content changes depending on diet using a randomised crossover study in healthy humans. Participants will be inpatients at the research facility for three separate 4-day visits. During each visit, participants will consume one of three diets, which differ in carbohydrate quality: 1) low-fibre refined diet; 2) high-fibre diet with intact cellular structures; 3) high-fibre diet where the cellular structures have been disrupted (e.g. milling, blending). On day 1, a nasoenteric tube will be placed into the distal ileum and its position confirmed under fluoroscopy. Ileal samples will be collected via the nasoenteric tube and metabolically profiled, which will determine the amount and type of carbohydrate present, and the composition of the ileal microbiota will be measured. Blood samples will be collected to assess circulating hormones and metabolites. Stool samples will be collected to assess faecal microbiota composition. Subjective appetite measures will be collected using visual analogue scales. Breath hydrogen will be measured in real-time as a marker of intestinal fermentation. Finally, an in vitro continuous fermentation model will be inoculated with ileal fluid in order to understand the shift in microbial composition and SCFA produced in the colon following the different diets.

Registration: ISRCTN11327221.
SNPnotes: high-throughput tissue-specific functional annotation of single nucleotide variants
Authors: Pai Shraddha , Apostolides Michael J. , Jung Andrew , Moss Matthew A.
Published: October 2019

A key challenge in the application of whole-genome sequencing (WGS) for clinical diagnostic and research is the high-throughput prioritization of functional variants in the non-coding genome. This challenge is compounded by context-specific genetic modulation of gene expression, and variant-gene mapping depends on the tissues and organ systems affected in a given disease; for instance, a disease affecting the gastrointestinal system would use maps specific to genome regulation in gut-related tissues. While there are large-scale atlases of genome regulation, such as GTEx and NIH Roadmap Epigenomics, the clinical genetics community lacks publicly-available stand-alone software for high-throughput annotation of custom variant data with user-defined tissue-specific epigenetic maps and clinical genetic databases, to prioritize variants for a specific biomedical application. In this work, we provide a simple software pipeline, called SNPnotes, which takes as input variant calls for a patient and prioritizes those using information on clinical relevance from ClinVar, tissue-specific gene regulation from GTEx and disease associations from the NHGRI-EBI GWAS catalogue. This pipeline was developed as part of SVAI Research's "Undiagnosed-1" event for collaborative patient diagnosis. We applied this pipeline to WGS-based variant calls for an individual with a history of gastrointestinal symptoms, using 12 gut-specific eQTL maps and GWAS associations for metabolic diseases, for variant-gene mapping. Out of 6,248,584 SNPs, the pipeline identified 151 high-priority variants, overlapping 129 genes. These top SNPs all have known clinical pathogenicity, modulate gene expression in gut tissues and have genetic associations with metabolic disorders, and serve as starting points for hypotheses about mechanisms driving clinical symptoms. Simple software changes can be made to customize the pipeline for other tissue-specific applications. Future extensions could integrate maps of tissue-specific regulatory elements, higher-order chromatin loops, and mutations affecting splice variants.
Depression-inducing drugs and the frequency of depression in Alzheimer’s disease and APOE ε4 carriers
Authors: Keine Dorothy
Published: October 2019

Background:Depression is associated with a greater risk of Alzheimer’s disease (AD). Drug-induced depression is a well-known side effect of many medications and is more likely to occur in those who have a higher risk of depressive disorder.

Methods:A total of 292 individuals ages 65 and older were included in this dataset. Depressive symptoms were determined through self-reporting, the Short Form Geriatric Depression Scale (SF-GDS), prior diagnosis, or use of antidepressant medication. Depression-inducing drugs (DIDs) were identified using published references.

Results:Individuals took 11.51 (SD 8.86) medications and 1.16 (SD 1.27) DIDs per person. Depressed patients were more likely to be taking at least one DID (71.15% vs 28.85%, P value 0.005). Of the total population, 60.56% were taking at least one DID. Those with APOE ε4 had a significantly higher rate of depression than those without (69.12% vs 30.88%, P value 0.03).

Conclusions:DIDs are a substantial clinical, medical, and public health problem in older populations. DID consideration is important in populations with an increased risk or diagnosis of AD. Clinical decision support software (CDSS) provides a reliable method to help with DIDs.
Digitalization of Information Processes of Auditing
Authors: Якимова Вилена , Yakimova Vilena
Published: October 2019

Th e article reveals the possibilities of transition of audit organizations to digital technologies, identifi es areas of application of big data analysis and artifi cial intelligence technology for processing and analyzing audited information, collecting, evaluating audit evidence and solving other intellectual problems. Th e article identifi es information processes in relation to auditing, gives their classifi cation based on the types of tasks to be solved, identifi es types of information when using digital technologies, and proposes a scheme of the intellectual system of audit activity.
Features of the Organization of the Internal Financial Audit in Budgetary Institutions
Authors: Парушина Наталья , Parushina Natalya , Лытнева Наталья , Lytnyeva Natalya
Published: October 2019

Th e article discusses the features of the organization of internal fi nancial audit in budgetary institutions, provides an overview of the practice of applying the provisions on internal fi nancial audit by budgetary institutions. Recommendations on the development of local regulations for the work of auditors are given, the powers of all participants in the budget process during the audit are divided, the stages of the audit are highlighted.
Property Taxes of Individuals in Russia: Problems of Calculus and Payment
Authors: Бобошко Диана , Boboshko Diana
Published: October 2019

In order to improve the tax literacy of citizens, this article examines the mechanisms for calculating property taxes of individuals. Th e paper overview electronic services, with which individual can check the correctness of property taxes calculations and recommendations of own tax burden planning.
Economically Motivated Adulteration in Farming Supply Chains
Authors: Levi Retsef , Singhvi Somya , Zheng Yanchong
Published: October 2019

Economically motivated adulteration (EMA) is a serious threat to public health. In this paper, we develop a modeling framework to examine farms’ strategic adulteration behavior and the resulting EMA risk in farming supply chains. We study both “preemptive EMA,” in which farms engage in adulteration to decrease the likelihood of producing low-quality output, and “reactive EMA,” in which adulteration is done to increase the perceived quality of the output. We fully characterize the farms’ equilibrium adulteration behavior in both types of EMA and analyze how quality uncertainty, supply chain dispersion, traceability, and testing sensitivity (in detecting adulteration) jointly impact the equilibrium adulteration behavior. We determine when greater supply chain dispersion leads to a higher EMA risk and how this result depends on traceability and testing sensitivity. Furthermore, we caution that investing in quality without also enhancing testing capabilities may inadvertently increase EMA risk. Our results highlight the limitations of only relying on end-product inspection to deter EMA. We leverage our analyses to offer tangible insights that can help companies and regulators to more proactively address EMA risk in food products.

This paper was accepted by Charles Corbett, operations management.
The Uncertain Value of Uncertainty: When Consumers Are Unwilling to Pay for What They Like
Authors: Moon Alice , Nelson Leif D.
Published: October 2019

Do people have an irrational dislike for risk? People pay less for uncertain prospects than their worst possible outcomes, and researchers have proposed that this effect occurs because people strongly dislike risk. We challenge this proposition across seven studies. Though people seem to irrationally dislike risky prospects when preference is assessed with open-ended pricing measures, such as willingness-to-pay, people display rational responses toward risky prospects when preference is assessed using rating measures, such as ratings of expected enjoyment. This discrepancy does not seem to arise because these measures (a) focus on different components of the uncertainty, (b) rely on context-dependent versus normed scales, or (c) involve voluntarily opting into an uncertain situation. Accordingly, we find that people also display rational responses toward risky prospects with time measures (i.e., willingness-to-wait and anticipated time usage) and choice. We discuss alternative explanations and crucial implications of our effects for both theory and application.

This paper was accepted by Yuval Rottenstreich, judgment and decision making.
Loyalty Program Liabilities and Point Values
Authors: Chun So Yeon , Iancu Dan A. , Trichakis Nikolaos
Published: October 2019

Problem definition: Loyalty programs (LPs) introduce a new currency—the points—through which customers transact with firms. Such points represent a promise for future service, and their monetary value thus counts as a liability on the issuing firms’ balance sheets. Consequently, adjusting the value of points has a first-order effect on profitability and performance and emerges as a core operating decision. We study the problem of optimally setting the points’ value in view of their associated liabilities. Academic/practical relevance: Firms across numerous industries increasingly utilize LPs. The sheer magnitude of LPs coupled with recent changes in accounting rules have turned the associated liabilities into significant balance-sheet items, amounting to billions of dollars. Managers (from chief financial officers to chief marketing officers) struggle with the problem of adjusting the points’ value in view of these liabilities. Academic work is primarily aimed at understanding LPs as marketing tools, without studying the liability angle. Methodology: We develop a multiperiod model and use dynamic programming techniques and comparative statics analysis. Results: We show that the optimal policies depend on a new financial metric, given by the sum of the firm’s realized cash flows and outstanding deferred revenue, which we refer to as the profit potential. The total value of loyalty points is set to hit a particular target, which increases with the profit potential. We find that loyalty programs can act as buffers against uncertainty, with the value of points increasing (decreasing) under strong (weak) operating performance and increasing with uncertainty. Managerial implications: Setting the point values and adjusting operating decisions in view of LP liabilities should be done by tracking the firm’s profit potential. Loyalty programs can act as hedging tools against uncertainty in future operating performance, which provides a new rationale for their existence, even in the absence of competition.
Understanding Hydrogen Sulfide in Inflammation: Opportunities and Challenges
Authors: Bhatia Madhav
Published: October 2019

Inflammation is an adaptive response to injury, but uncontrolled inflammation can lead to tissue damage and disease. Research in our laboratory (since confirmed in different laboratories worldwide) has shown that hydrogen sulfide (H2S) acts as a mediator of inflammation in different disease conditions. Learning about a novel mediator of inflammation results in unique opportunities with which to approach inflammatory diseases. At the same time, the complexity of biological systems and translation of research from the bed to the bedside also presents challenges. This Editorial aims to discuss the opportunities and challenges in relation to the role of H2S in inflammation, and the future prospects for this research.
The Co-Active Therapeutic theatre model: A manualized approach to creating therapeutic theatre with persons in recovery
Authors: Wood Laura L. , Mowers Dave
Published: October 2019

Therapeutic theatre is the intentional use of the process and performance of a theatrical piece with specific therapeutic goals and intentions for an identified population. Study and replication of this modality may benefit from manualization. This article presents an outline of a manualized
approach called The Co-Active Therapeutic theatre (CoATT) model, which has been used as a successful intervention for individuals post-intensive treatment who are working towards independent recovery from eating disorders, aphasia and substance use disorders. This preliminary instruction of
CoATT emphasizes a solution-focused, manualized process to support recovery and operationalize therapeutic theatre in the service of empirical research.
‘I Am Who I Am- ’: Archetypal drama therapy workshops for Asian American adoptees
Authors: Kim Oh Myo , Ginther Amy Mihyang
Published: October 2019

Adopted individuals of colour may experience a number of additional challenges in comparison to non-adoptees due to both pre and post-adoptive stressors. This exploratory study examined four workshops based on drama therapy techniques focusing on archetypal journeys. The majority of
participants (N = 24) were Asian American adopted adults between the ages of 24 and 62 years (M age = 34.5 years). In response to an open assessment and Likert scale survey, participants reported that the workshop was both reflective and interesting, although at the same time, it was challenging
and sometimes uncomfortable. Participants noted the benefits of using their body and voice, the power of incorporating Korean language and the meaningfulness of having an ‘all-adoptee space’.
Materiales de filiación e inspiración griega en Calatrava la Vieja: la cerámica ática de barniz negro y de figuras rojas y sus interpretaciones locales
Authors: Miguel Naranjo Pedro , Martínez-González Javier
Published: October 2019

En este artículo se aborda el estudio de todas las cerámicas griegas conocidas en Calatrava la Vieja (Carrión de Calatrava, Ciudad Real) hasta la actualidad, ofreciendo una información cronocultural relevante ya que permite asegurar la vigencia del oppidum oretano que aún yace bajo los niveles medievales. Este estudio también permite asegurar el momento en el que Calatrava se integró en las redes de comercio de productos griegos con todas las implicaciones culturales que supone, como la producción local de formas y decoraciones griegas.
La domus de la calle Añón de Caesar Augusta (Zaragoza) y el programa decorativo del triclinium
Authors: Guiral Pelegrín Carmen , Íñiguez Berrozpe Lara María , Mostalac Carrillo Antonio
Published: October 2019

Estudio de la arquitectura de la domus, así como de la estratigrafía constatada en la excavación, atendiendo a los informes realizados en el año 2000 por J. A. Pérez Casas. Las pinturas y pavimentos que decoraron el triclinio se realizaron en tres fases decorativas. A la primera corresponden un pavimento de terrazo blanco con decoración de teselas negras y la pintura del techo, de época Claudia y decorado con un repertorio ornamental relacionado con el universo dionisiaco. En época flavia se repintan las paredes con un sistema compositivo articulado en una alternancia de paneles amarillos con cenefas caladas e interpaneles decorados con columnas carentes de función arquitectónica. En el interior de los paneles se disponen una pareja de putti que portan atributos divinos (rayo de Júpiter y una crátera) y un amor/cupido adolescente con tirso. En esta misma época se incluye en el pavimento un emblema de opus tessellatum trícromo. Finalmente, problemas relacionados con la humedad obligan a rehacer el zócalo con imitaciones de mármoles. Tras el estudio, consideramos que puede establecerse el origen de los talleres, itálico el que pinta el techo y local el que decora las paredes.
Caracterización de un nuevo marmor polícromo bético explotado en época romana
Authors: Rodríguez Gutiérrez Oliva , Jiménez Madroñal Diego
Published: October 2019

El presente trabajo pretende dar a conocer, de forma más sistemática que las breves noticias parciales hasta ahora publicadas, una variedad de marmor polícromo empleado en época romana en construcciones y elementos en diferentes ciudades béticas, con especial concentración en el valle del Guadalquivir. El estudio incluye su caracterización petrográfica básica, así como la identificación de los principales contextos de uso, con valiosos datos tanto en lo que se refiere a la dispersión de los materiales como al volumen y naturaleza de la extracción. Asimismo se avanza en una propuesta de carácter territorial destinada a identificar los lugares más propicios para la ubicación de la cantera antigua, desconocida hasta la fecha, así como los resultados del posterior trabajo de campo realizado a partir de dichas hipótesis de localización.
Faustina la Menor y Julia Domna como matres castrorum. Dos mujeres al servicio de la propaganda imperial de las dinastías Antonina y Severa
Authors: Conesa Navarro Pedro David
Published: October 2019

En este artículo pretendemos estudiar a las emperatrices Faustina la Menor, esposa de Marco Aurelio y Julia Domna, mujer de Septimio Severo. Para ello, tomaremos como punto de análisis la concesión del título de mater castrorum a ambas mujeres. Pese a la visión, en cierta manera idílica, que se ha pretendido reflejar del gobierno del sucesor de Antonino Pío, durante dicha época las fronteras del Imperio comenzaban a evidenciar cierta inestabilidad. Por tanto, asistimos a una situación sin precedentes. Faustina era honrada con el título de mater castrorum, convirtiéndose en la primera emperatriz de Roma en recibirlo. Septimio Severo, primer representante de la dinastía de los Severos, llegó a ser emperador tras una cruenta guerra civil. Además de autoproclamarse hijo de Marco Aurelio y hermano de Cómodo, toda su familia fue partícipe de su propaganda dinástica. Era frencuente ver a Julia Domna con peinados similares a los de Faustina y, también, recibiendo parecidas condecoraciones como fue el caso del título de mater castrorum. En este trabajo, por tanto, pretendemos abordar, en la medida de lo posible, cuáles fueron las motivaciones y causas para la concesión de dicho título. Observaremos cómo las mujeres se adentraban en un ambiente que era eminentemente masculino como era el militar.
Feedstock availability and moisture content data processing for multi-year simulation of forest biomass supply in energy production
Authors: Aalto Mika , Korpinen Olli-Jussi , Ranta Tapio
Published: October 2019

Simulation and modeling have become more common in forest biomass studies. Dynamic simulation has been used to study the supply chain of forest biomass with numerous different models. A robust predictive multi-year model requires biomass availability data, where annual variation is included spatially and temporally. This can be done by using data from enterprises, but in some cases relevant data is not accessible. Another option is to use forest inventory data to estimate biomass availability, but this data must be processed in the correct form to be utilized in the model. This study developed a method for preparing forest inventory data for a multi-year simulation supply model using the theoretical availability of feedstock. Methods for estimating quality changes during roadside storage are also presented, including a possible parameter estimation to decrease the amount of data needed. The methods were tested case by case using the inventory database âBiomass Atlasâ and weather data from a weather station in Mikkeli, Finland. The data processing method for biomass allocation produced a reasonable quantity of stands and feedstock, having a realistic annual supply with variation for the demand point. The results of the study indicate that it is possible to estimate moisture content changes using weather data. The estimations decreased the accuracy of the model and, therefore, estimations should be kept minimal. The presented data preparation method can generate a supply of forest biomass for the simulation model, but the validity of the data must be ensured for correct model behavior.
Predictive factors of ketoacidosis in type 1 diabetes mellitus
Authors: Listianingrum Listianingrum , Patria Suryono Yudha , Wibowo Tunjung
Published: October 2019

Background Diabetic ketoacidosis (DKA) is an acute complication in type 1 diabetes mellitus (DM) and a significant cause of morbidity and mortality in developing countries. Diabetic ketoacidosis can be prevented by good management of the disease. Risk factors from previous studies that increase the DKA incidence were peripubertal age, female gender, low socio-economic status, low parental education status, DKA at the first diagnosis of type 1 DM, infection, psychological problems, poor metabolic control, and non-compliance with insulin treatment.

Objective To determine whether sex, age, socio-economic status, parental education level, DKA at the initial diagnosis of type 1 DM, infection, psychological problems, poor metabolic control, and failing to take insulin as needed were predictive of DKA in type 1 DM patients.

Methods We conducted a retrospective cohort study using medical records from type 1 DM patients aged 0-20 years, at the Department of Child Health, Dr. Sardjito Hospital, Yogyakarta, from January 2011 to May 2017. We assessed for the incidence and predictors of DKA. Logistic regression analysis was done to determine which factors increased DKA incidence.

Results A total of 57 type 1 DM patients were recruited, with DKA incidence of 37 (65%). Five (8.8%) DKA patients died. Multivariate analysis revealed that infection (OR 5.23; 95%CI 1.47 to 19.68; P=0.014) and DKA at the first diagnosis of type 1 DM (OR 5.37; 95%CI 1.40 to 19.52; P=0.011) were significant risk factors for DKA.  

Conclusion  Infection and DKA at the first diagnosis of type 1 DM are significant predictors of increased DKA incidence.
Implementing Yogyakarta Pediatric Cancer Registry for 16 years
Authors: Mulatsih Sri , Hariningrum Adnina , Purwanto Ignatius , Oktasari Rizki
Published: October 2019

Background A hospital-based cancer registry can be used as a guide to decision-making. Considering the limited cancer registry data in the population, the Yogyakarta Pediatric Cancer Registry (YPCR) is one of the pioneers of hospital-based pediatric cancer registries in Indonesia. The YPCR was started in 2000 in Dr. Sardjito Hospital.

Objective To describe the characteristics of childhood cancer and the outcomes by analyzing overall survival (OS) and event-free survival (EFS) based on data from Yogyakarta Pediatric Cancer Registry.

Methods Data were collected from the YPCR for the period of 2000 to 2016. Childhood cancers were classified into 12 groups based on the 3rd edition International Classification for Childhood Cancer (ICCC). Incidence, frequency, and distribution of cases were grouped by sex, age, and patients’ place of residence. Incidence was further analyzed using SPSS software. Kaplan-Meier test was used to analyze OS and EFS.

Results Within the study period, 2,441 children aged 0-18 years were diagnosed with cancer. The highest incidence was found in the 1-5-year age group. The most common diagnoses found were leukemia, myeloproliferative disorders, and myelodysplastic disease (58%); lymphoma and reticuloendothelial neoplasm (8%); retinoblastoma (6%); soft tissue and other extra-osseous sarcomas (5%); as well as neuroblastoma and other peripheral nervous cell tumors (5%). The OSs of acute lymphoblastic leukemia (ALL), high risk ALL (HR-ALL), and standard risk (SR-ALL) were 31.8%, 18.5%, and 43.9%, respectively. The EFSs of ALL, HR-ALL, and SR-ALL were 23.9%, 14.7%, and 32.4%, respectively. For solid tumors, the OS was 13.7% and EFS was 6.4%.

Conclusion The number of new cases of childhood cancer has increased in the last few years. The Yogyakarta Pediatric Cancer Registry (YPCR), which serves as a hospital-based pediatric cancer registry, has an important role to evaluate clinical and non-clinical aspects of childhood cancer.
Fluid overload and length of mechanical ventilation in pediatric sepsis
Authors: Paramitha Winda , Triasih Rina , Rusmawatiningtyas Desy
Published: October 2019

Background Children with sepsis often experience hemodynamic failure and would benefit from fluid resuscitation. On the other hand, critically ill children with sepsis have a higher risk of fluid accumulation due to increased capillary hydrostatic pressure and permeability. Therefore, fluid overload may result in higher morbidity and mortality during pediatric intensive care unit (PICU) hospitalization.

Objective To evaluate the correlation between fluid overload and the length of mechanical ventilation in children with sepsis admitted to the PICU.

Methods Our retrospective cohort study included children aged 1 month-18 years with sepsis who were admitted to the PICU between January 2013 and June 2018 and mechanically-ventilated. Secondary data was extracted from subjects’ medical records. Data analyses used were independent T-test and survival analysis.

Results Of 444 children admitted to the PICU, 166 initially met the inclusion criteria. Of those, 17 children were excluded due to congenital heart disease. Subjects’ median age was 19 months and median PELOD-2 score was 8. Eighteen children (12.1%) had positive fluid balance in the first 48 hours. Median mechanical ventilation duration was 5 days. Fluid overload was significantly correlated with length of mechanical ventilation (P=0.01) and PICU mortality (RR=2.06; 95%CI 2.56 to 166; P=0.001). Neither length of PICU stay nor extubation failure were significantly correlated to fluid overload.

Conclusion Fluid overload was significantly correlated with length of mechanical ventilation and may be a predictor of mortality in children with sepsis in the PICU.
Vascular endothelial growth factor (VEGF) expression in induction phase chemotherapy of acute lymphoblastic leukemia
Authors: Daud Dasril , Astari Merlyn Meta , Ridha Nadirah Rasyid
Published: October 2019

Background Leukemia is a hematolymphoid malignancy originating from bone marrow. The progression of hematolymphoid malignancies depends on new formation of vasculature, called angiogenesis. Angiogenesis is regulated by vascular endothelial growth factor (VEGF), which is secreted by paracrine and autocrine signaling mechanisms.

Objective To evaluate VEGF expression in induction phase chemotherapy of acute lymphoblastic leukemia (ALL) patients.   

Methods This prospective, cohort study was conducted in ALL patients admitted to Dr. Wahidin Sudirohusodo Hospital, Makassar, South Sulawesi, from October 2016 to October 2017. Subjects’ VEGF levels were measured at diagnosis and at the end of induction chemotherapy.

Results VEGF levels were analyzed in 59 patients, 29 of whom were diagnosed with standard risk ALL and 30 patients with high risk ALL. VEGF levels were significantly decreased after induction phase chemotherapy in standard risk ALL and in high risk ALL  subjects. There was no significant difference in VEGF levels before induction phase chemotherapy between the standard and high risk groups (P=0.405). There was also no significant difference in VEGF levels after induction phase chemotherapy between the two risk groups (P=0.094).

Conclusion The VEGF level is significantly lower after ALL induction phase chemotherapy in both the standard risk and high risk ALL groups. However, there are no significant differences in VEGF levels between the standard and high risk groups before as well as after induction phase chemotherapy.
Acute hematogenous osteomyelitis in children: a case series
Authors: Irianto Komang Agung , Gema Adhinanda , Sukmajaya William Putera
Published: October 2019

Background Chronic osteomyelitis is still a major cause of morbidity and disability in children living in developing countries. Neglect of acute osteomyelitis and its progression to chronic osteomyelitis leads to significant morbidity. This report is the first series to describe such cases in Indonesia.

Objective To describe 12 pediatric cases of chronic osteomyelitis in order to remind clinicians about the debilitating complications of musculoskeletal infection.

Methods This report is a case series of 12 children with chronic osteomyelitis admitted to dr. Soetomo General Hospital, Surabaya, East Java, in 2011-2017. We acquired data from medical records. The patients’ quality of life was measured using the Child Health Assessment Questionnaire Disability Index (C-HAQ-DI).

Results The patients’ mean age was eight years and they were predominantly male. The most common infection location was the femur (7/12). Microbial cultures were positive in 9/12 of cases, predominantly with Staphylococcus aureus. Erythrocyte sedimentation rate (ESR) was elevated in 11 patients. All patients were diagnosed late, with an average delay of presentation to Orthopedics of 10.5 months. Most of patients experienced mild to moderate disability after the disease, as assessed by the C-HAQ-DI.

Conclusion Diagnosis of osteomyelitis in children is quite difficult, given the lack of specific diagnostic tests. Delayed diagnosis and inappropriate treatment may result in long-term morbidity and disability. Clinicians should have an increased awareness of the clinical features of osteomyelitis, including unusual presentations such as calcaneal osteomyelitis.
KOMPETENCJE POCZĄTKUJĄCEGO NAUCZYCIELA JĘZYKA ANGIELSKIEGO W ŚWIETLE MODELU KARDS B. KUMARAVADIVELU
Authors: Werbińska Dorota
Published: October 2019

This article focuses on first-year English teachers’ competences from the perspective of teachers themselves. The point of reference is offered by B. Kumaravadivelu’s (2012) language teacher education KARDS model (KNOWING, ANALYSING, RECOGNIZING, DOING and SEEING), which is based on cognitive and social constructivism. Providing an answer to progressing economic and educational globalization, the model stresses the need for verification of what contemporary language teachers’ competences constitute, For this reason the study described in the article seeks to find out how the competences of first-year teachers, as seen by the teachers themselves, match the requirements suggested in the model.
Beliefs and attitudes about language lerning and teaching among learners in lower secondary schools in Poland
Authors: Ellis Melanie
Published: October 2019

Artykuł omawia założenia i metodologię badań, przeprowadzonych na reprezentatywnej próbie w szkołach gimnazjalnych w Polsce, których celem było opisanie postaw i poglądów na temat uczenia się i nauczania języków obcych w szkołach. Niezbędne do przeprowadzenia analizy dane zostały zebrane za pomocą kwestionariusza, w którym około 4000 respondentów wyraziło swoje opinie, dotyczące 60 zagadnień, w pięciostopniowej skali Likerta. Niniejszy artykuł prezentuje wybrane wyniki badań.
Wprowadzenie
Authors: Janowska Iwona , Seretny Anna
Published: October 2019

Wprowadzenie.
CERTYFIKACJA ZNAJOMOŚCI JĘZYKA POLSKIEGO JAKO OBCEGO WE WŁOSZECH: PROBLEMY, WYZWANIA, POSTULATY
Authors: Marzec Urszula , Marzec Małgorzata
Published: October 2019

The article contributes to the discussion regarding the state certificate Since the new legislation in 2015 was introduced, the number of foreign sessions of the state certificate examinations in Polish as a foreign language has significantly decreased. The article aims to show the impact of the amended legal provisions on the availability of the certificate examinations outside of Poland and, consequently on the level of knowledge about them among potential candidates in Italy. The article is based on the results of the survey conducted by the authors among the students of Polish studies in Italy.
CERTYFIKACJA KOMPETENCJI JĘZYKOWYCH A ROZWÓJ ZAWODOWY ŻOŁNIERZY W POLSKICH SZKOŁACH WOJSKOWYCH
Authors: Iwanowska Anna
Published: October 2019

At present, soldiers who want to serve abroad have to achieve a specific level of language proficiency both in its general and professional variety. To prove their competences, they have to take examinations compatible with STANAG 6001 standards. The purpose of this article is to present the impact of formal assessment on soldiers’ professional development in Polish military schools and the factors which are crucial to soldiers’ successful language learning.
Winners and Losers of Universal Health Insurance: A Macroeconomic Analysis
Authors: Ng Wung Lik , Wang Yin-Chi
Published: October 2019

This paper studies the supply-side distortions and the consequences resulted from provider-side cost containing universal health insurance (UHI) scheme. A two-sector overlapping generations model of endogenous physicians’ specialty choice is presented. We find that the general public is possible to be benefited from the cost containing UHI if the quality of medical services does not deteriorate too much. However, physicians in the medical service sector suffer from such scheme and end up earning lower incomes, regardless of one’s specialty and talent. Inequality among physicians also increases.
Serum bile acids profiling by liquid chromatography-tandem mass spectrometry (LC-MS/MS) and its application on pediatric liver and intestinal diseases
Authors: Fu Xiaowei , Xiao Yi , Golden Jamie , Niu Sizhe , Gayer Christopher P.
Published: October 2019

Background

A method for bile acid profiling measuring 21 primary and secondary bile acids in serum samples was developed and validated with liquid chromatography-tandem mass spectrometry (LC-MS/MS). Sample preparation included spiking with internal standards followed by protein precipitation, centrifugation, drying under nitrogen gas and reconstitution. Extracted samples were injected onto a Phenomenex Kinetex C18 column (150 × 4.60 mm, 2.6 μm).

Methods

Data was collected with LC-MS/MS operated in negative ion mode with multiple reaction monitoring (MRM) and single reaction monitoring (SRM). The analytical run time was 12 min.

Results

The method showed excellent linearity with high regression coefficients (>0.99) over a range of 0.05 and 25 μM for all analytes tested. The method also showed acceptable intra-day and inter-day accuracy and precision. As a proof of concept, the analytical method was applied to patients with neonatal intrahepatic cholestasis caused by citrin deficiency (NICCD), biliary atresia (BA), and necrotizing enterocolitis (NEC), and distinct bile acids profiles were demonstrated.

Conclusions

The method could be poised to identify possible biomarkers for non-invasive early diagnosis of these disorders.
Meshfree approach on buckling and free vibration analysis of porous FGM plate with proposed IHHSDT resting on the foundation
Authors: Kumar Rahul , Lal Achchhe , Singh B. N. , Singh Jeeoot
Published: October 2019

In the present work, new inverse hyperbolic higher-order shear deformation theory (IHHSDT) is proposed and implemented for buckling analysis and free vibration analysis of porous Functionally Graded Material (FGM) plate on the foundation. The proposed theory follows the approximately parabolic distribution of the transverse stresses through the plate thickness and satisfies the conditions of continuity and differentiability. Three different types of porosity distribution considered. Governing differential equations (GDEs) of the plate is developed in the framework of proposed theories by Hamilton’s principle. Multiquadrics radial basis function (MQ-RBF) based Meshfree method used for discretizing the GDEs. The result obtained by the present theory is validated with the three-dimensional elastic theory and other available solutions in the literature to ensure the efficacy and accuracy of the proposed theory. Numerical results obtained for buckling and free vibration for porous FGM plate resting on the foundation. Effect of grading index, porosity fraction, porosity distribution, the effect of foundation, and the span to thickness ratio have discussed. The secured results can consider as a benchmark for future studies.
Thermo-Mechanical Post Buckling Analysis of Multiwall Carbon Nanotube-Reinforced Composite Laminated Beam under Elastic Foundation
Authors: Lal Achchhe , Markad Kanif
Published: October 2019

In present paper, buckling analysis is performed over laminated composite beam incorporating multi walled carbon nanotube (MWCNT) polymer matrix and then reinforced with E-glass fiber in an orthotropic manner under inplane varying thermal and mechanical loads by finite element method (FEM). Aim of the study is to develop a model which accurately perform the buckling deterministic analysis of multi-walled carbon nanotube reinforced composite laminated beam (MWCNTRCLB) with the evaluation of material property by applying Halpin–Tsai model. Combined Higher order shear deformation theory and Pasternak elastic foundation based on von Karman nonlinear kinematics and Winkler cubic nonlinearity respectively, are successfully implemented. Through minimum potential energy principle, generalized static analysis is performed using FEM, based on interactive MATLAB coding. The critical buckling load and critical buckling temperature is presented under the action of inplane variable mechanical and thermal load, with different boundary conditions, beam thickness ratio and MWCNT aspect ratio, variation with MWCNT volume fraction and coefficient of thermal expansion, with and without foundation for linear and nonlinear cases.
Analysis of concrete shallow funicular shells of rectangular plan
Authors: Sabermahany Hadi , Rasouli Erfan , Mofid Massood
Published: October 2019

Analysis of concrete shallow funicular shells of rectangular plan with simply supported boundary conditions under static loads is performed using the Ritz method. Double Fourier series with the unknown constant coefficients are assumed for the displacement components of the shell and their unknown coefficients are determined such that the potential energy of the shell becomes minimum. The solution is presented in a simple form and is suitable for practical applications. The responses of rectangular–plan concrete shallow funicular shells including deflections, strains, internal forces, internal moments and stresses could be easily determined using the proposed semi-analytical method. The Ritz method results are verified against the finite element method results.