bluuebunny/crossref_metadata_2025 huggingface dataset:
Analysis of the results of application of the rational-emotive behaviour therapy for mothers of newborns with hypoxic affection of the central nervous system
Authors:   St. Petersburg State University, Mamaychuk Irina , Milanich Yulia ,   St. Petersburg State University
Published: January 2023

Parents of hospitalized newborns tend to experience more severe psychological distress. Rel- evant to this is the impact on the specific irrational beliefs of mothers for the purpose of improving adaptation to the life situation. It is necessary to study the possibilities of cognitive- behavioral methods of intervention in working with this client category. The objective of this work is to study the dynamics of distress indicators in mothers of newborns with hypoxic affection of the central nervous system (CNS) in the process of the program developed on the basis of rational-emotive behaviour therapy (REBT). The study included 98 mothers of newborns with hypoxic affection of CNS. Based on the results of a semi-structured inter- view, 80 mothers were identified with a dysfunctional type of response to a life situation. The intervention group (N=50) received 8 REBT sessions for three weeks. The main target for psychotherapy was irrational beliefs, which underlie negative emotions and non-constructive ways coping with stress caused by hospitalization and facing information on the condition and developmental prognosis of a newborn. The control group (N=30) received one consul- tation session. To assess the dynamics of distress indicators, the Integrative Anxiety Test and Zung Self-Rating Depression Scale were used before and after the program in the intervention group and with an interval of three weeks in the control group. In the intervention group, the indicators of depression, situational anxiety, emotional discomfort and the phobic component of anxiety decreased. In the control group, the indicators of situational anxiety and asthenic component of anxiety decreased. In comparison with the control group, the mothers in the intervention group showed more significant positive changes. The programs developed on the basis of REBT have moderate efficacy in reduction of the distress in mothers of newborns with hypoxic affection of CNS.
Personal strengths (VIA model) among teachers of different generations
Authors:   Center for Socialization, Family and Prevention of Antisocial Behavior Research of Moscow State Pedagogical University, Rean Artur , Stavtsev Aleksey ,   Center for Socialization, Family and Prevention of Antisocial Behavior Research of Moscow State Pedagogical University, Shevchenko Andrey ,   Center for Socialization, Family and Prevention of Antisocial Behavior Research of Moscow State Pedagogical University
Published: January 2023

This article describes the relationship between the expression of 24 personality strengths (in the VIA model) and age-related affiliation in teachers. The actuality and novelty of this study is the use of innovative methodological apparatus in the paradigm of generational research. The aim of the article is to study the correlation between the teachers’ age group and the expression of personality strengths in the VIA (Values in Action) model, one of the key models in the framework of positive psychology research area. The study was participated by educators from different regions, the age of the respondents was 18–75 years, the study group of respondents totaled N = 7938. The research shows the dynamics of changes in personality strengths depending on the generation of teachers. The personality strengths that are best described by generational changes are also presented, such as: love, spirituality, love of learning, gratitude, sense of humor, prosocial activity. The difference in the expression of personality strengths depending on the age of teachers was revealed. Using statistical analysis, it was found that teachers born between 1970 and 1979 have a significant “statistical slump” in the scales of curiosity, breadth of vision, courage. In some cases, “statistical drawdown” of “Spirituality” scale value is observed for the generation 1992–2002 in comparison with other generations. Also, the codrop of the 1992–2002 generation and the 1980–1991 generation was discovered to be: “Love for Learning”, “Kindness”, “Humility”, “Forgiveness”, “Gratitude” and “Prosocial Activity”. The presented model is an important step in the study of the interrelationships of 24 personality strengths in the context of the professional characteristics of the individual. With the help of the results of this study, it is possible to evaluate approaches to stimulating the personal potential of teachers of different ages. In the future, it is possible to study generational differences using the VIA model in other professional areas as well.
INTERACCIÓN GENOTIPO AMBIENTE EN ESTRÉS TÉRMICO Y PRODUCCIÓN DE LECHE EN VACAS HOLSTEIN EN LA REGIÓN DE LIMA, PERÚ
Authors: Menendez-Buxadera Alberto , More Montoya Manuel , Gutiérrez-Reynoso Gustavo , Galván Cavero Gerardo
Published: January 2023

Un total de 352596 resultados de los controles periódicos de producción (TD), así como así las variables climáticas de Temperatura y Humedad Relativa combinadas en un índice conocido como ITH, realizados en 5 establos de la región de Lima, entre enero del 2006 y diciembre del 2018, estuvieron disponibles para este estudio. Esta base de datos estaba representada los TD de 11876 vacas Holstein hijas de 8439 madres y 321 sementales y fue estudiada por diferentes modelos de regresión aleatoria con el objetivo de estimar las relaciones genéticas entre TD y el ITH como indicador de estrés térmico (ST). Los resultados indicaron que la heredabilidad (h2 ), a lo largo de la escala de ITH manifiesta una tendencia ligeramente ascendente (h2 = 0,113±0,01 a 0,187±0,02) hasta alcanzar sus mayores valores en la denominada zona de estrés térmico (ITH>=68 a ITH=77). Las correlaciones genéticas (rg) fueron cercanos a la unidad entre niveles de ITH adyacentes o muy cercanos y disminuye en la medida que se incrementa las diferencias entre la intensidad de ST medida por los ITH, alcanzando resultados entre rg= 0,562±0,09 a 0,582±0,12 entre la zona de más frío (ITH<=61) y más calor (ITH >=71). Las correlaciones entre los Valor Genético (BV) estimados en ambas zonas fue de 0,607 y solo 262 de los mejores 600 animales seleccionados fueron mejores en ambas zonas. Estas respuestas indican que los resultados de TD no debe considerarse como expresión del mismo rasgo en toda la trayectoria de ITH, en otras palabras, existe interacción genotipo ambiente. Se confeccionó un índice basado en todos los estimados de los BV a lo largo de ITH que permitió identificar no solo la existencia de variación genética en ST sino también variaciones en la forma de respuesta de los animales a los diferentes niveles de ITH.
RENTABILIDAD DEL CULTIVO DE TARA Caesalpinia spinosa (MOLINA) KUNTZE EN APURÍMAC, PERÚ
Authors: Gómez Oscorima Raquel , Diez Matallana Ramón , Vasquez Quispe Carolay , Vargas Oviedo José
Published: January 2023

Dado su potencial para mejorar la economía campesina por sus crecientes exportaciones debido a los múltiples usos de sus derivados, se plantea el objetivo de analizar la mejora en rentabilidad al cultivar tara Caesalpinia spinosa (Molina) Kuntze en Apurímac, en vez de simplemente recolectarla. Para probar la hipótesis que cultivar tara es más rentable que recolectarla, se usa el presupuesto parcial para obtener los beneficios por hectárea a corto plazo, y el flujo de caja para evaluar la magnitud del incremento en rentabilidad en el largo plazo. Como la agricultura está sujeta a riesgos, se emplea un enfoque probabilístico con el software @Risk. Se concluye que el cultivo de tara tiene mayor rentabilidad que recolectar el producto lo cual explicaría el avance de las siembras de este cultivo en Apurímac y el Perú, por lo que se recomienda a las instituciones interesadas en el desarrollo de los Andes peruanos evaluar también los beneficios económicos del cultivo de otras especies forestales
A importância do vínculo afetivo mãe bebê para o seu desenvolvimento
Authors: De Paula Maria Karoline Ferreira da Silva Honorato , Silva Jannaína Sther Leite Godinho da , Souza Alessandra da Silva , Silva Eliara Adelino da , Gomes Elisângela do Nascimento Fernandes , Silva Catia Maria Santos Diogo da
Published: January 2023

Este estudo teve como objetivo descrever a importância do desenvolvimento do vínculo afetivo em mãe e bebê ainda nos primeiros momentos de vida. Trata-se de um estudo qualitativo, exploratório descritivo realizado através de uma revisão bibliográfica de literatura de caráter integrativo, com o intuito de correlacionar as diversas estratégias utilizadas para a promoção do estabelecimento precoce do vínculo afetivo mãe-bebê, os obstáculos dos profissionais de saúde no momento do parto imediato na preservação de estabelecer esse vínculo nos primeiros minutos de vida. Os resultados apontam para a importância do desenvolvimento do vínculo afetivo entre mãe e bebê nos primeiros momentos de vida. Por fim, a promoção do vínculo afetivo entre mãe e bebê é fundamental no processo do seu desenvolvimento, atentando sobre a sua importância, a Golden Hour, Hora de Ouro ou Hora Dourada, que é a primeira hora de vida do bebê.
Palavra-chave: Contato Pele a Pele; Enfermagem; Humanização; Recém-nascido; Vínculo Afetivo Mãe e Bebê.
Adesão aos cinco momentos de higienização das mãos na terapia intensiva em tempos de COVID-19
Authors: Constantino Milena de Queiroz , Souza Claudia Regina da Costa de , Batista Raquel Pereira , Marins Aline Miranda da Fonseca , Pinto Cecília Maria Izidoro , Oliveira Francimar Tinoco de
Published: January 2023

Objetivos: avaliar a adesão da equipe multiprofissional aos cinco momentos de Higienização das mãos no cenário de Terapia Intensiva de pacientes acometidos por COVID-19, e, comparar a densidade de incidência de micro-organismos multirresistentes no período pré e trans pandemia na Unidade de Terapia Intensiva. Métodos: estudo seccional, descritivo, retrospectivo onde a amostra foi extraída dos registros do banco de dados de monitorização de Higienização das Mãos da Coordenação de Controle de Infecção Hospitalar da instituição. Para tratamento dos dados foi utilizada estatística descritiva (frequência, medidas de tendência central e de dispersão) e analítica com o teste qui quadrado de Pearson e Teste Exato de Fisher. Resultados: Foram analisadas 377 oportunidades de Higienização das Mãos obtendo uma adesão de 34%. A equipe de enfermagem obteve maior número de oportunidades de Higienização das Mãos, enquanto a equipe de fisioterapia obteve menos oportunidades. O momento “após o contato com o paciente” obteve maior conformidade quando comparado com o momento “após o contato”. Quanto à escolha de solução, os enfermeiros utilizaram mais água e sabão, e, médicos e técnicos de enfermagem utilizaram mais solução alcoólica. Comparando os momentos com a escolha de solução, no momento “após o contato com o paciente” houve preferência por utilizar água e sabão. Quando comparado no trans pandêmico observou-se elevada incidência de micro-organismos multirresistentes.
Palavras-Chave: Higiene das Mãos; Unidade de Terapia Intensiva; Equipe multiprofissional; COVID-19.
Protótipo de um material educativo tecnológico: comunicação inovadora em saúde com os surdos
Authors: França Brenda da Silva , Almeida Elayne Araujo de , Tavares Marilei de Melo
Published: January 2023

Objetivo: apresentar um protótipo em desenvolvimento que pretende facilitar a comunicação entre profissional da saúde e paciente surdo alfabetizado em Libras. Metodologia: protótipo de um material educativo – aplicativo, desenvolvido a partir de uma pesquisa sobre tecnologia, saúde e comunicação com paciente surdo na atenção primária. Resultados preliminares: o conteúdo do material educativo em saúde para auxiliar na comunicação com os surdos deve ter por base a simplicidade, o que proporciona um fácil entendimento de seu uso. Abranger um vocabulário com o máximo de palavras e frases possíveis, separados por categorias de consultas, possibilitando a visualização do sinal. Apesar de ser um primeiro passo, o presente protótipo é inédito e inovador no âmbito da saúde na atenção básica.
Palavras-Chave: Tecnologia; Comunicação; Pessoas com Deficiência Auditiva.
Diagnosis and Prognosis of Non-small Cell Lung Cancer based on Machine
Learning Algorithms
Authors: Zhou Yiyi , Dong Yuchao , Sun Qinying , Fang Chen
Published: January 2023

Background:

Non-small cell lung cancer (NSCLC) has been the subject of intense
scholarly debate. We aimed to identify the potential biomarkers via bioinformatics analysis.

Methods:

Three datasets were downloaded from gene expression omnibus database (GEO). R
software was applied to screen differentially expressed genes (DEGs)and analyze immune cell infiltrates.
Gene set enrichment analysis (GSEA) showed significant function and pathway in two
groups. The diagnostic markers were further investigated by multiple machine learning algorithms
(least absolute shrinkage and selection operator (LASSO) and support vector machine-recursive
feature elimination (SVM-RFE)). Various online analytic platforms were utilized to explore the
expression and prognostic value of differential genes. Furthermore, western blotting was performed
to test the effects of genes on cell proliferation in vitro.

Results:

We identified 181 DEGs shared by two datasets and selected nine diagnostic markers.
Those genes were also significantly overexpressed in the third dataset. Topoisomerase II alpha
(TOP2A) is overexpressed in lung cancer and associated with a poor prognosis, which was confirmed
using immunohistochemistry (IHC) and western blotting. Additionally, TOP2A showed a negative
correlation with immune cells, such as CD8+ T cells, eosinophils and natural killer (NK) cell.

Conclusion:

Collectively, for the first time, we applied multiple machine learning algorithms,
online databases and experiments in vitro to show that TOP2A is a potential biomarker for lung
adenocarcinoma and could facilitate the development of new treatment strategies.
The Effect of Bisoprolol on Premature Ventricular Complex in Vietnamese
Patients with Hypertension and Left Ventricular Hypertrophy
Authors: Kim Tran Son , Ngo Toan Hoang , Phuong Nguyen Anh Thi , Ngoc Huynh Huyen Thi , Vo Cuong Tan , Bao Nguyen Ngan Ngoc , Nguyen Thang Hoang , Huynh Minh Van
Published: January 2023

Background:

Premature ventricular contraction (PVC) is a common arrhythmia that causes a
large number of clinical symptoms, adversely impacts the quality of life, and can even initiate serious
arrhythmias, such as ventricular tachycardia or ventricular fibrillation. The incidence of premature ventricular
contraction is higher in hypertensive patients, particularly if concomitant left ventricular hypertrophy
(LVH) is present.

Objectives:

This study was conducted on the characteristics of PVC in hypertensive patients with left
ventricular hypertrophy and aimed to evaluate the effect of bisoprolol on PVC in Vietnamese patients
with hypertension and LVH.

Subjects and Methods:

We conducted a study to determine how bisoprolol potency affected PVC
management in the group with both high blood pressure and LVH. We selected a convenient sample of
all patients who came to the Medical Examination Department at the Can Tho University of Medicine
and Pharmacy Hospital and met sampling criteria with hypertension, LVH on echocardiography, and
PVC on 12-leads electrocardiogram. Over 2 years, we collected 76 patients who satisfied the above
conditions. Out of which, 50 patients were indicated for management with bisoprolol, and 26 patients
were excluded from the study, including 7 patients with asthma and 19 patients who had simple PVC on
a 24-hour Holter ECG. Data were analyzed with SPSS version 22.

Results:

Fifty patients participated in the study, of whom 70% were female. It is clear that palpitation
was the most prevalent symptom (66%), and 38% of patients had complicated PVC (Lown III-V). When
treating PVC with bisoprolol, 50% of patients achieved the treatment goal with a decrease in the number
of PVCs of more than 70%, accompanied by symptom relief and eradication of dangerous PVCs. After
4 weeks of treatment, bisoprolol decreased the number of PVCs, heart rate, and blood pressure while also
easing PVC-related symptoms (p < 0.05).

Conclusion:

Low-dose bisoprolol effectively reduces the number of PVCs in hypertensive patients
with LVH.
Recent Updates on Structural Aspects of ALK Inhibitors as an Anticancer Agent
Authors: Asati Vivek , Ayaz Md Shahid , Bhupal Ritu , Sharma Priyanka , Sahu Adarsh , Singh Parwati , Gupta Ghanshyam Das
Published: January 2023

Presently, several protein kinases have been discovered with the aim to treat various cancers. Anaplastic
lymphoma kinase (ALK) is a tyrosine kinase receptor that plays a role in the pathogenesis of a wide variety of human
cancers known as ALCLs, NSCLC, ovarian cancer, breast cancer, colorectal cancer, neuroblastoma, etc. The fulllength
ALK receptor is a classical receptor tyrosine kinase composed of an amino-terminal extracellular domain and an
intracellular tyrosine kinase domain. Crizotinib is a strong oral small-molecule first tyrosine kinase inhibitor of ALK to
be used in the treatment of ALK-dependent NSCLC. Due to the drug resistance of first generation ALK inhibitors,
researchers are trying to design and synthesize novel ALK inhibitors with various heterocyclic rings in which 2,4-
diarylaminopyrimidine derivatives with a specific N-(3-pyridinylmethyl)urea moiety, 2-amino-4-(1-piperidine) pyridine
derivatives, 7-azaindole and carboxamide derivatives and some others produced potential compounds. To overcome
drug resistance, to get better affinity and to reduce drug toxicity, there is an urgent need for novel ALK inhibitors.
The present review describes the ALK signaling, their inhibitors and related structure activity relationships for the
development of potential ALK inhibitors.
Application of Photo-inactive Ru(edta) Complexes in Photocatalytic Small
Molecules Transformation over Semiconductor Surface - A Perspective
Authors: Varangane Sagar , Pal Ujjwal , Chatterjee Debabrata
Published: January 2023

Photocatalytic transformation of small substrate molecules to useful products through an environmentally benign and economically viable pathway is a challenging area of research of continual importance. This review focuses on our perception of the application of ruthenium(III) complexes comprising ‘edta’ ligand (edta4- = ethylenediaminetetraacetate) as a ‘redox mediator’ or ‘relay’ in photocatalytic electron transfer reaction pertaining to the conversion of small substrate molecules viz. hydrazine to ammonia, bicarbonate to formate, dioxygen to hydrogen peroxide. In this article, the prospect of [RuIII(edta)(H2O)]- and [RuIII(edta)(pz)]- to act as ‘redox mediator’ or ‘molecular catalysts’ in photocatalytic transformations of aforesaid small molecules are assessed systematically.
Mating and Reproduction in the Wax Moth: A Sequence of Events
Authors: Marwaha Lovleen
Published: January 2023

The wax moth adults prefer to mate on trees near the bee farm. For mating,
they exhibit a specific behavioural pattern that includes the male's production of
ultrasonic sound waves, wing vibration by the female moth, and pheromonal release by
the male moth. After mating, the gravid female returns to the hive and oviposits there.
The pairing in this moth occurs in a sex–role reversal manner rather than the typical
moth signalling system. The male moth produces ultrasonic sound and pheromonal
signals in this insect, whereas females have chemical signals in other moths. In other
words, pairing in the wax moth occurs by releasing pheromones and wing fanning,
attracting female moths with a response to wing fanning.
Furthermore, the presence of the female moth induces the male to produce ultrasonic
sounds that attract the female and make her receptive to courtship. The current chapter
elucidates signalling in the male wax moth, the response of the female exclusively to
the male's mating calls and volatiles released by the male to guide her for the mating.
Comparatively, more detailed information is available on the greater wax moth (GWM)
than, the lesser wax moth (LWM) concerning insect biology, laboratory rearing,
morphology, anatomy, physiology, genomics, proteomics, mating, reproduction,
immunity, and plastic degradation capacity.
Gamelan Gong Beruk in the ritual of Ngusaba Desa in Pemaksan Bangle Temple, at Abang Districts Karangasem
Authors: Yudarta I Gede , Garwa I Ketut , Wardizal Wardizal , Yulianti Ni Ketut Dewi , Kariasa I Nyoman
Published: January 2023

The aims of this study to reveal the religiosity of the gamelan Gong Beruk it found in the Bangle Traditional Village, Bunutan Village Abang Districts, Karangasem Regency. This Gamelan is a traditional music ensamble it is very unique and the only one in Bali. As the Bangle peolpe’s culture creations, this gamelan has an important function to accompany the prosession and implementation of ngusaba desa ceremony in the Pemaksan Bangle Temple. There are two problems will be disscussed in this study they are How the process appearance of the gamelan Gong Beruk and how the function of it in the implementation in ngusaba desa in Pemaksan Bangle Temple. Both of these topics is very interensting because until this time the existence of gamelan Gong Beruk not widely to known by the public, and this gamelan has an important function in implementation of ngusaba desa in the Pemaksan Bangle Temple. This study is used the descriptive kualitative method where the data will be find from observation, interview, literature review and document study. The data analysis is carried out from the data collection process, reduction and conclusion.
Farmers and Poverty: Farmer Complaints and Problems in Mutunggeding Village
Authors: Gunawan Fransiskus Xaverius Candra , Mesa Asinkritus Ngongo Lalu Manu , Syah Robby Firman , Simandjorang Bonataon Maruli Timothy Vincent , Fitri Suci Emilia
Published: January 2023

Poverty reduction strategies should refer to who and why poverty occurs to make sustainable development programs effective for the welfare of society. The research aims to describe the problem conditions of the farmer households in Mutunggeding Village, Umalulu District, East Sumba Regency, with an overview of natural assets and human and physical resources. The research method used descriptive qualitative based on secondary and primary data from observations, documentation, and in-depth interviews with 102 randomly selected farmers to answer 41 key questions. The study results found that most farmers were young farmers with paddy fields and gardens, had low education and had supporting skills and good health. However, these land assets have yet to function optimally to meet household economic needs due to a scarcity of subsidized fertilizers, minimal hand tractors, and uneven distribution of irrigation water. This condition will be even more severe if the farmer must bear the burden of customs and culture, so you must go into debt and pawn your paddy fields. On the other hand, the strength of the community's social assets is a strong capital to survive against poverty. Therefore, the Government needs to strengthen the synergy of farmer groups, agricultural BP3K, and BUMDesa in overcoming the fundamental problems experienced by farmers and also needs to strengthen the institutional capacity of BUMDesa as a foundation for improving the people's economy.
Síntesis de nanoencapsulados de quitosano como sistemas portadores de fitosanitarios
Authors: Orjuela-Palacio Juliana Marcela , Pérez-Calderón John , Zaritzky Noemí E.
Published: January 2023

La alicina (All) es un bioactivo con actividad antimicrobiana, antioxidante y de alta efectividad en el control de insectos y el quitosano (Qs) forma nanoencapsulados al interactuar con tripolifosfato de sodio (tpp), por lo que al pensar en la síntesis de nanoencapsulados como sistemas portadores de All con efectos fitosanitarios es de interés agroindustrial. Por lo anterior, en este estudio se sintetizaron y caracterizaron nanoencapsulados de All (NQsAll) mediante la técnica de gelificación ionotrópica. La síntesis consistió en: (i) formulación de complejos All:Qs en proporción de 0,2 g de All por 1 g Qs, partiendo de una solución de Qs (1%p/v) y un fitosanitario comercial con concentración de All = 0,6 % p/v; (ii) obtención de los sistemas NQsAll partiendo de All:Qs adicionando tpp (0,06 % p/v). Se evaluaron dos relaciones en masa de TPP:Qs (5:1 y 3:1) y por medio de ftir-atr se observaron las bandas correspondientes a los grupos sulfóxidos (1119 cm-1), la vibración de estiramiento de las aminas primarias vinculadas a All (1072 cm-1), se comprobó la interacción electrostática de TPP:Qs y se determinó el diámetro medio de partícula (DM) y el potencial-Z (PZ) de los sistemas. La relación TPP:Qs influye significativamente, siendo NQsAll (5:1) la que presentó una mejor estabilidad y un menor tamaño (PZ = 0,67 mV; DM = 144,6 nm). Se evaluó el porcentaje de inhibición del radical dpph• comprobando que la nanoencapsulación preservó la capacidad antioxidante. Así, NQsAll (5:1) mostró el mejor desempeño para formular un sistema nanoportador. Estos sistemas son una buena alternativa para la conservación de All e incrementan la dispersión y la humectabilidad durante la aplicación en el cultivo.
A Systematic Literature Review for Interface design of pelvic floor muscle training mobile app base on mHealth 2017-2022 (Preprint)
Authors: Yi Zao
Published: January 2023

BACKGROUND

With the rapid development of information technology, mobile electronic equipment has been popularized. The survey by the World Health Organization shows that mHealth is rising worldwide, and mHealth has been applied to many medical and health fields. Pelvic floor muscle training（PFMT）is the first-line treatment for women with urinary incontinence, and patients can self-manage and practice through the PFMT application. The design of the PFMT app will affect the user's experience and adherence. Through the collection and collation of literature, this paper classified and elaborated the current research results related to the application of PFMT and explored the direction and evidence to promote the improvement of the app interface.

OBJECTIVE

Review the existing research on the PFMT app, to identify what the current research on the PFMT app concentrations on. From which to find and summarize the research on PFMT existing obstacles and future improvement strategies for app interface design.

METHODS

Keywords were searched in three major citation databases: Web of Science, Scopus, and Dimensions to find the literature published. After screening the titles and abstracts of all retrieved citations with inclusion and exclusion criteria, the researchers need to review the full text and then final discussion and confirm the relevance of all included papers. First, identify the current research area on PFMT application from each paper. Second, the existing suggestion to improve interface design were extracted from certain topic research. Finally, the research topic classification and interface design problem summary are carried out.

RESULTS

A total of 26 papers and one supplement were included. 7 primary research directions were identified. 6 key issues and 3 crucial pages of interface design are sorted out, which provides direction and a root for the progress of interface design in the future.

CONCLUSIONS

Many studies have suggested the necessity and estimation of interface redesign, but there is no advanced study and implementation. The interface design of PFMT app is one of the important directions for future application iteration and upgrading. The interface design will help reduce stigma and enhance the user experience, which to a great extent contributes to strengthening user engagement and adherence.
In cihuatlahueliloc. La “mala mujer” en textos cristianos en lengua náhuatl del siglo XVI
Authors: Mancisidor Montserrat
Published: January 2023

A partir de distintos textos en lengua náhuatl elaborados por frailes mendicantes en el siglo XVI, muchas veces con la colaboración de letrados indígenas, pueden observarse las  enseñanzas en torno al comportamiento femenino inculcadas a los pueblos nativos. El artículo analiza las estrategias adoptadas por varios autores para predicar sobre las mujeres, particularmente en torno a los pecados de la vanidad y la lujuria, y cómo a la vez que reprodujeron nociones e imágenes traídas de Europa, se retomaron también elementos de las culturas indígenas, para construir una peculiar representación de lo que ellos consideraron una “mala mujer” o “cihuatlahueliloc”.
Servir en la tierra para gozar en el cielo.
Authors: Ayala Hernández Andrea
Published: January 2023

Las doctrinas del siglo XVIII reflejan las estrategias de evangelización utilizadas por los catequistas para enseñar la doctrina a los indígenas y evidencian, también, la construcción de un catecúmeno, en cuanto sujeto cristiano, basado en las ideas en torno a los indios como miserables, predominantes en la época, mismas que tenían su origen en creencias religiosas medievales y fueron utilizadas para justificar la empresa colonizadora, dando como consecuencia la conformación de una sociedad jerárquica, que inculcó en el catecúmeno una identidad inferiorizante acerca de sí mismo, la cual imperó y siguió en construcción aún en el tardío siglo XVIII.
Pertunjukan Amal: Dana Awal Perjuangan Rakyat di Yogyakarta 1945-1947
Authors: Arvianita Ihza , Basuki Yuli Eko
Published: January 2023

This research discusses the existence of charity shows in Yogyakarta as one of the people’s efforts to support the financial needs of independence struggle bodies. As the capital of the revolution, Yogyakarta’s atmosphere was filled with patriotic spirit to defend independence, and its society supported the birth of struggle organizations. To finance their activities, people conducted fundraising activities, such as by organizing charity shows. This method was chosen because of its effectiveness in mobilizing charity-fund from society, since at the same time they also enjoyed entertainment. The shows were presented in the form of theater and cinema. From these charity shows, the collected funds were distributed to various independence struggle bodies such as People’s Militia, Independence Funds Agency, and the Indonesian Red Cross (PMI).
Antara Netralitas dan Keberpihakan: Palang Merah di Jawa pada Masa Perang (1945–1949)
Authors: Saputra Rizky Eka
Published: January 2023

This research discusses about the role PMI (Indonesian Red Cross) and NERKAI (Nederlandsche Roode Kruis afdeeling Indonesië) in Java during Indonesian Independence War 1945-1949. As one of the most important institutions in wartime, the Indonesian Red Cross (PMI and NERKAI) was in a dilemmatic position. They had to obey the state for which they served, but on the other hand, they had to adhere to the fundamental principle of the International Red Cross. These dual functions have to be carried by the two Red Cross organizations, led them to abandon their neutrality. This study was designed to explain the reason why the two Red Cross organizations involved in the Indonesian Independence War abandoning their neutrality principle. This research found out, at least, four factors influenced the partiality actions of the Red Cross, first, the special status of the Red Cross in wartime; second, the unclear definitions of “Red Cross independent”; third, sentiment of the Indonesian nationalism; and fourth, the presence of militarism in the Red Cross.
Bapak jang Telah Mendahului ke Alam Baka: Kemangkatan Jenderal Sudirman dalam Kenangan Tentara, Publik, dan Rezim
Authors: Dwicahyo Satrio
Published: January 2023

As a national hero, the biography of General Sudirman has been extensively written. Like other biographical works, most of Sudirman’s biographies are concluded with his death. However, as a grand figure, Sudirman’s departure left empty spaces that prompted people to commemorate him. The commemorations did not only serve melancholic but rather pragmatic purposes. Shortly after he passed away in 1950, the Indonesian army began to narrate Sudirman’s death as a method to unite the divided officer corps. Although Sudirman was a Japanese-trained officer, he managed to maintain peaceful relations between Indonesian officers who received training under the Dutch (KNIL) and the Japanese (PETA) military. Although he has passed away, the army remained to utilize his “post-mortem” influence to mediate the peaked conflict between two factions. “Bringing Sudirman into alive” successfully ended the KNIL-PETA friction but was unable to prevent the follow-up conflict. Sukarno and Suharto also utilized Sudirman’s name to pursue their respective political interests. Sukarno positioned Sudirman as the champion of nationalism under the framework of Nationalism-Religion-and Communism or Nasakom ideology. For Suharto, Sudirman’s fame was useful to alter the influence of Sukarno, his archrival. This article combines a biographical approach with obituary writing. The present study accessed newspapers, magazines, and radio news as primary sources and complemented it with secondary literature.
EFFECT OF HEAT TREATMENT ON POTASSIUM CONTENT AND ANTI-SHIGELLOSIS ACTIVITY OF KLUTUK BANANAS (MUSA BALBISIANA COLLA) FRUIT FLOUR
Authors: KUSUMA SRI AGUNG FITRI , RAMDHANI DANNI , SETIAFIANTI EMMANUEL MELATI
Published: January 2023

Objective: to investigate the effect of heat treatment on the potassium content and anti-shigellosis action of klutuk banana fruit flour.

Methods: The klutuk banana fruit slices were heat-treated using a validated oven under varied parameters of 30-50 °C for 15–40 h. Based on its minimum inhibitory concentration (MIC) value and the potassium analysis, the selected condition was then applied to the processing of bananas to produce stable flour. Atomic Absorption Spectrophotometry (AAS) was used to quantify the potassium concentration after the MIC value was calculated using the microbroth dilution method.

Results: The best heat treat for the anti-shigellosis activity with a MIC of 3.125 mg/ml was at 50 °C for 20 h. The amount of potassium in the flour of klutuk banana fruit that had the best anti-dysentery activity was 0.3773 mg/ml or 9.76% of the total potassium content. But according to our research, the lower water content of banana flour caused by longer drying times and higher temperatures had no effect on the existence of antimicrobial metabolites.

Conclusion: The potassium gain and anti-shigellosis action of klutuk banana fruit were thus significantly impacted by heat during the flour-processing stage.
ANTIBACTERIAL ACTIVITY OF LIQUID CRYSTAL NANOPARTICLES GEL OF BINJAI LEAVES METHANOL EXTRACT (MANGIFERA CAESIA JACK. EX. WALL.) AGAINST PROPIONIBACTERIUM ACNES
Authors: RAMADHAN HAFIZ , FORESTRYANA DYERA , JAMALUDIN WAHYUDIN BIN , PALGUNO SATRIYO KRISNA
Published: January 2023

Objective: This study aims to compare the anti-Propionibacterium acnes activity between the optimum formula of gel liquid crystal nanoparticles of Binjai leaves methanol extract and the gel of extract without the liquid crystal nanoparticles system.

Methods: Preparation of liquid crystal nanoparticles using top-down methods with 6% Capmul-GMO 90 and 5% Plantacare 818. Preparation of the optimum gel formula using 7% Viscolam Mac 10 as a gelling agent. The antibacterial activity was evaluated by cup plate technique and clindamycin was used as a positive control.

Results: The results obtained are liquid crystal nanoparticles based gel of methanol extract of Binjai leaves produces a strong category as anti-Propionibacterium acnes with an average inhibition of 15.33±1.2413 mm and the gel of extract without the liquid crystal nanoparticles system only produces 13.53±1.241 mm.

Conclusion: The gel of Binjai leaves extract with a liquid crystal nanoparticles system has a higher antibacterial effect on Propionibacterium acnes than the gel of extract without the liquid crystal nanoparticles system.
NATURAL PLANT REMEDIES FOR DEPRESSION DURING THE COVID-19 PANDEMIC, UPDATE REVIEW
Authors: WILAR GOFARANA , PUTRI SRI BETHA , KUSMARA BUNGA MUSTIKAWATI , AGITA KIVA
Published: January 2023

COVID-19 is disease caused by SARS-CoV-2 virus which was first discovered in Wuhan, China on the end of 2019. The COVID-19 pandemic generates many sufferers to experience symptoms of depression. Natural plant has been used for a long time for various ailments, including depression. This literature review aims to describe various types of plants and their mechanisms that can be used to help deal with symptoms of depression during the COVID-19 pandemic. This article was compiled by conducting a literature search using the keywords “covid-19”, “depression”, and “natural products” on PubMed, Scopus and Cochrane Library engine searching and followed the inclusion criteria, namely, the maximum literature publications from the last 10 y in English and discuss natural products that can be used to help overcome depression during the covid-19 pandemic.  We found that thirteen medicinal plants are noteworthy to be considered as antidepressant drug candidates. The medicinal compounds need to be developed furthermore in the future since Covid-19 pandemic is not over yet. These plants have established the molecular mechanism to remedies depression and hopefully can be alternatives medicine to treat depression that have mild side effects compared to synthetic drugs.
CHEMICAL AND PHARMACOLOGICAL PROPERTIES OF SELECTED MEDICINAL PLANT SPECIES FROM GENUS PREMNA AND THEIR IMMUNOMODULATORY POTENTIALS
Authors: BELINDA ANDHARA MARSHA , FEBRIYANTI RADEN M. , MUHAIMIN
Published: January 2023

Epidemiological data today show an increase in immune diseases; hence increasing awareness to maintain and increase the body's immunity is essential. Immunomodulators are substances that improve the human immune system by stimulating, inhibiting, or regulating components in the immune system. Plants produce secondary metabolites which provide beneficial effects on human health, including immunomodulatory properties. Natural immunomodulators can be used to minimize side effects and toxicity compared to synthetic materials because using synthetic immunomodulators may result undesirable side effects, such as pulmonary toxicity, myelosuppression, alopecia, and nephrotoxicity. Besides that, using plants as medicine is safer to use, more effective against a wide spectrum of pathogens, and relatively cheaper than synthetic medicine. Some of the medicinal plants which have immunomodulatory properties belong to the genus Premna from Lamiaceae. Alkaloids, flavonoids, phenolics, saponins, terpenoids, polysaccharides, and fatty acids supported the pharmacological effect of Premna sp. as immunomodulatory agent. The present work reviews some species in genus Premna, which were the subject of literature search based on major scientific databases, including PubMed, Elsevier, SpringerLink, Science Direct, Scopus, Mendeley, and Google Scholar. This review presents a series of selected plants from genus Premna sp. including their chemical and pharmacological properties as well as immunomodulatory potential.
A PHYSIOCHEMICAL STUDY ON DRUG DELIVERY OF METFORMIN HCL-LOADED CS-PLGA NANOPARTICLES
Authors: SUDJAROEN YUTTANA , THONGKAO KANITTADA , THONGMUANG PIMPORN
Published: January 2023

Objective: The current research was based on developing CS-PLGA nanoparticles (NPs) drug delivery system (DDS) for improving the bio-availability of metformin HCl, an anti-diabetic drug.
Methods: Nanoprecipitation method was utilized to prepare the metformin HCl-loaded CS-PLGA NPs DDS. The metformin HCl-loaded NPs were validated using an analytical method and characterization of NPs was also done. These polymers release the drug in a controlled manner.
Results: The correlation coefficient (R2) value for the metformin HCl calibration curve was 0.9971 in phosphate buffer pH 6.8 at a concentration range of 0-12 μg/ml. Metformin HCl-loaded NPs release the drug at 144 h, approximately 90%. DSC tests were carried out for 50 mg and 75 mg of MET HCl incorporated NPs and FT-IR for 50 mg of MET HCl incorporated NPs, it was clear from the FT-IR and DSC spectra that there were no interactions between the metformin HCl and the polymer.
Conclusion: It was proven that metformin HCl-loaded NPs act as a prominent DDS by exhibiting extensive drug release and an increase in its bioavailability.
INTERACTIONS OF XANTHONE COMPOUNDS FROM THE MANGOSTEEN (GARCINIA MANGOSTANA L) PERICARPS AGAINST INOS, COX-1, AND COX-2 ENZYME RECEPTORS AS ANTI-INFLAMMATORY
Authors: LESTARI DWINTHA , SARI RISKA PERMATA , MUSFIROH IDA , MEGANTARA SANDRA , PRACEKA MEILINDA SETYA , KHAIRUL IKRAM NUR KUSAIRA , MUCHTARIDI
Published: January 2023

Objective: Mangosteen is a plant that is very effective for inflammation. Besides that, the skin of the mangosteen plant in Indonesia continues to be developed because it is an antioxidant and suppresses the production of cytokines.
Methods: Screening pharmacophores and molecular docking simulations by molecular modeling computation to predict the activity of the Mangosteen plant in silico and to determine potential drug candidates from mangosteen for inflammation to the iNOS, COX-1, and COX-2.
Results: Pharmacophore Screening, γ-mangosteen has the highest pharmacophore fit score of 33.32 and 33.64 on COX-1 and COX-2 and is selective to iNOS target. Molecular docking of α-mangosteen and γ-mangosteen test compounds to the active site of used, COX-1, and COX-2 enzymes showed free energy binding (ΔG °) values of,-5.09,-5.00,-6.15; and-6.76,-5.30,-7.81 Kcal/mol respectively. Meanwhile, hydrogen bonds and good ΔG ° values ​​were formed between γ-mangosteen and COX-2, where the Hydroxyl group on γ-mangosteen interacted with the amino acids His75, Ser339, and Ala513 with ΔG ° of-7.81 Kcal/mol.
Conclusion: It can be said that α-mangosteen and γ-mangosteen have molecular interactions with COX-1 and COX-2 active sites with the highest affinity for COX-2 compared to COX-1, and iNOS.
DESIGN, DEVELOPMENT AND EVALUATION OF NOVEL MOUTH DISSOLVING FILM OF TOFACITINIB CITRATE
Authors: RAYKAR MEGHANA , VELRAJ MALARKODI
Published: January 2023

Objective: The aim of the present study was to design and evaluation of mouth dissolving oral films of tofacitinib citrate allowing fast reproducible drug dissolution in oral cavity thus bypassing the first-pass metabolism to enhance the patient convenience and effective treatment for rheumatoid arthritis.
Methods: Films have been prepared by way of solvent casting technique by using Hydroxypropyl methylcellulose (HPMC), sodium carboxymethylcellulose, sodium alginate, and gelatin had been used as the hydrophilic film-forming polymeric bases and glycerol as plasticizer. The prepared film evaluated for in vitro disintegration time, tensile strength, content uniformity, folding endurance, swelling index, and in vitro drug release.
Results: The results of prepared film pH of all the selected formulation were ranging between 6.1 to 7.5. Thickness of the films was found in the range of 0.07 to 0.19 mm. The folding endurance was found to vary between 95.7 to 105.4-fold, Disintegration time was found 25 to 35, Drug content was found to be for F3 and F6 formulation i.e., 99.035±1.37 and 99.014±0.79.
Conclusion: Thus, the current study successfully designed, developed an optimized Tofacitinib citrate formulation.
MODELING, BINDING SITE, AND IMMUNOGENICITY ANALYSIS OF GENES ENCODING L-ASPARAGINASE FROM ARTHROSPIRA PLATENSIS NIES 39
Authors: PRIHANTO ASEP A. , NURSYAM HAPPY , NURDIANI RAHMI , MUYASYAROH HIDAYATUN , HAYATI ROYANI L. , MIFTACURROCHMAH ANIS
Published: January 2023

Objective: This work aimed to study the modeling, binding site, and immunogenicity analysis of genes encoding L-asparaginase from Arthrospira platensis NIES 39.
Methods: Physicochemical characteristic of the gene was analyzed using ProtParam. I-TASSER, PROCHECK, ProSA, and ProQ were used to build the L-asparaginase model. The enzyme's binding site was achieved based on the SiteMap and COACH analysis. Immunogenicity analysis was based on MHC II binding epitopes on the immune epitope database with further epitope prediction, such as NN-align, SMM aligns, Combinatorial library, and Net MHCIIpan.
Results: The result showed that the protein had an aliphatic index of 94.46. It was dominated by strand, helix, and coil groups. The best template for building the model was the malonate-bound human L-asparaginase protein. The amino acid at 173,191,193, 201, 204, 205, 223, and 225 positions served as binding sites. The best substrate for A. platensis NIES 39 asparaginase was L-asparagine. There is no substantial evidence that the protein is highly allergenic.
Conclusion: In conclusion, this is the first report on the character of ASNase from microalgae A. platensis where the enzyme has the potential to be applied for health applications because of its low allergenicity.
INTRANASAL FORMULATION AND CHARACTERIZATION OF CHITOSAN MICROSPHERE FOR IMPROVING IN VITRO MUCOADHESION, RESIDENCE TIME AND ABSORPTION RATE OF PREGABALIN
Authors: PETHE ANIL , HADKE ANKIT , AGRAWAL SURENDRA , TELANGE DARSHAN
Published: January 2023

Objective: Chitosan-based pregabalin microsphere (CBPM) formulation was prepared to improve in vitro mucoadhesion and absorption of pregabalin via intranasal administration.
Methods: The CBPM formulations were prepared using the inotropic gelation method and optimized using the Box-behnken design. The optimized CBPM formulation was physico-chemically characterized using scanning electron microscopy, thermal analysis, Fourier transform infrared spectrometry and powder x-ray diffraction. Additionally, the CBPM formulation was characterized for functional parameters such as in vitro mucoadhesion, in vitro drug release, ex vivo permeability across the sheep nasal mucosa and in vivo anticonvulsant activity in pentylenetetrazol (PTZ)-induced seizures model in mice.
Results: The design-optimized CBPM exhibited a 91.45 % inclusion efficiency of pregabalin in the microspheres. The Physico-chemical analysis of the individual components and the optimized formulation confirmed the formation of CBPM. The in vitro mucoadhesion study revealed ~80% mucoadhesive of the CBPM to the sheep nasal mucosa. The in vitro dissolution profiles of CBPM was significantly higher (~97%) than that of pure pregabalin (~70%). The CBPM displayed a higher rate and extent of permeability (~90%) than pure pregabalin (~76%) across the sheep nasal mucosa. The in vivo anticonvulsant activity showed that intranasal administration of CBPM resulted in significant (P<0.01) protection against PTZ-induced convulsions in mice.
Conclusion: The chitosan-based microsphere intranasal formulation could be employed as promising delivery for rapid pregabalin absorption.