bluuebunny/crossref_metadata_2025 huggingface dataset:
aportes de la filosofía para niños y niñas a la educación ecosocial
Authors: Agundez rodriguez Adolfo
Published: March 2023

Today, people are better informed about environmental degradation than ever before. However, this does not imply that people are more engaged toward ecological issues nor are they more committed to achieve greater ecological justice. In this respect, environmental education is paradigmatic: the current generation of young people is, by far and without any doubt, the most knowledgeable and aware of environmental problems thanks, among other things, to the presence since the end of the 20th century of environmental education in primary and secondary school. However, levels of commitment to ecological issues that are significantly higher than before are not observed, except when it comes to individual pro-environmental behavior. How to link environmental awareness with a collective, political, ecosocial and ecocitizen commitment? In order to advance avenues for reflection on this issue, firstly this article presents the elements that characterize the current ecosocial crisis. Secondly, it addresses the ecosocial crisis as a crisis of knowledge that ultimately points to the challenge of transforming the visions of the world. Thirdly, it considers the ecosocial crisis as an opportunity that opens up the possibility of creating new worlds on the planet. Fourthly, the ecosocial crisis is presented as a crisis of contemporary education. Fifthly, it summarizes the two risks to consider in the practice of ecosocial education: the risk of dogmatism and the risk of blaming individuals for global problems. Finally, some clues are proposed that point to the Philosophy for children program as a program that can support the educational practice needed by the current educational and ecosocial crisis, as well as limits recognized risks of ecosocial education.
the paratexts of cpi: emergent findings of an inquiry in iran
Authors: Shokrollahzadeh Soudabeh , Khosronejad Morteza
Published: March 2023

This article presents the emergent findings of research conducted in Iran. It’s main objective was to investigate whether adolescents' thinking could turn polyphonic in CPI and what processes, thinking would go through to achieve this objective. Seventeen adolescents, ten girls, and seven boys participated in fourteen sessions with three iranian and three foreign novels as the materials of inquiry. The sessions were videotaped and analyzed by the researchers. The findings discovered out of pre-determined objectives revealed that CPI was effective in developing adolescents' polyphonic thinking, and polyphonic thinking processes at work were also revealed. At the same time, some unexpected data emerged which gave rise to some emergent findings, among which was that meaning-making is not limited to what happens “inside” the CPI, but some events before, after, and during the sessions are decisive in meaning-making within this communal circle and formation of CPI. We named them ‘paratexts’ of CPI that included WhatsApp chats, religious, educational, scientific, and gender discourses, the extension of issues discussed at CPI to school and home, adolescent dialogues before and after the sessions, and their reading of philosophical ideas and literary commentaries on the materials of inquiry. Gérard Genette, giving currency to the term ‘paratext’, conceives of it as an undefined zone between the inside and the outside of a printed work that forms the complex mediation between book, author, publisher, and reader. It is a border zone in which text and off-text enter dialogue the paratexts associated with CPI directed us to reconfigure the practice in reconsideration of the facilitator’s roles and positions. On this account, the facilitator is someone who needs to be able to actively listen both to the voices of the group members and the voices of existing paratexts, and to manoeuvre between multiple roles and positions as the situation demands.
inverting questions: an invitation to take a stroll on another side of questions
Authors: Sousa Júlio Miguel araújo
Published: March 2023

This paper has two objectives: to explore how inverting questions in the Community of Philosophical Inquiry (Kennedy, 2004) can be a useful tool for triggering thought processes; and, more generally, to explore the importance of inverting the role traditionally given to children as bystanders to their own education and thought processes. On this basis, we will assume that children have an epistemic and political voice and that this voicing, placed on equal standing with the adult voice, is long overdue. It is undeniable that questions have a central role in P4C sessions (Costa-Carvalho E Mendonça, 2020; Costa-Carvalho E Kohan, 2020) and that, in the context of any given community of philosophical inquiry, they can trigger (Kennedy, 2004) a wide range of thought processes. Some questions may be too vague and require sharpening to adequately address the problem at hand, while others may promote a metacognitive approach to the issue under discussion, and to the entire thought process that sustains it. We will explore how inverting questions may be useful in this context. Moreover, we will consider how this thought anastrophé may emerge in concrete philosophical discussions with children. Our argument will, therefore, navigate the intersection between language and thought, logic and semantics, and theory and practice. Assuming that the term “inversion” may offer different understandings, we will try to outline this rhizomatic approach (Deleuze and Guattari, 1987) to the concept. We will focus primarily on the child’s point of view, which we hold to be epistemologically privileged (Kennedy, 2020). It is our core belief that children´s voices should be granted scientific and political standing and that an epistemic inversion between adulthood and childhood in education must be explored.
an open-ended story of some hidden sides of listening or (what) are we really (doing) with childhood?
Authors: Haynes Joanna , Carvalho Magda Costa
Published: March 2023

The paper arises from a shared event that turned into an experience: the finding of a childlike piece of paper on our way to a conference about philosophy in schools and how it affects our educational ideas and research practices on listening to children. Triggered by the question of what it means to listen, we are led to the exercise of self-questioning inspired by some of the authors that have already written about the topic, specifically in the context of the community of philosophical enquiry. The thinking unfolds with the telling of the story about the found piece of paper, crossing different layers of questioning and trying to keep the enquiry open for the readers: what is it that we do not know about listening to children? And to what extent might that, which we do not know, be the cause of biased and adultist practices? Is it necessary to return to what philosophy is and where one can find it inside the school environment? Is it already there when the adults arrive? Are we not listening to it? Or are there specific places for philosophical conversations, such as the classroom? Is philosophy also invited to the margins of those spaces? Who decides what counts as philosophical? It is not about answering questions and giving closure to our concerns as educators and researchers, but rather sharing with the readers how even in the least suspected place - an academic event about bringing philosophy to school - one might still not be listening to children. In returning to this self-questioning movement, we want to echo some of the troubling in the thinking and practices of listening in the so-called movement of Philosophy for/with Children: this for/with phenomenon, its politics and relations; some of the assumptions that might be present in the dilemmas in practice for educators and researchers; but also its aesthetics resonances, the sheer beauty of troubling, the (out of) tune of self-questioning, the questions it raises for us as researchers and the space of doubting and uncertainty it offers, like a hesitation or a breathing space. And perhaps, we wonder, it is in-between spaces, in its cracks and transitions, that important things can find their way into our thinking and conversations about childhood. Just like a piece of paper in a hotel room.
EDUCAÇÃO PROFISSIONAL E TECNOLÓGICA E NEOLIBERALISMO NO BRASIL: RETROCEDER, TREINAR E CAPACITAR PARA A PRECARIZAÇÃO
Authors: Oliveira Tiago Fávero de
Published: March 2023

Este texto analisa como o neoliberalismo modela uma nova perspectiva sobre a educação profissional e tecnológica. Neste sentido, o objetivo do artigo é analisar qual a visão e o lugar da EPT na sociedade neoliberal. A partir de uma análise histórico-descritiva, a pesquisa  usará de autores do campo crítico para entender as mudanças dirigidas à formação para o trabalho no Brasil. Logo em seguida, o estudo relaciona o neoliberalismo com traços fundamentais das novas políticas de formação profissional, indicando pontos como o rejuvenescimento da Teoria do Capital Humano, o retorno da Pedagogia das Competências e a emergência de discursos ligados ao empreendedorismo, a meritocracia e a precarização do trabalhador. Ao final, será possível perceber que as políticas atuais atuam num cenário regressivo em que uma formação ampla, pautada na ciência e na emancipação dá lugar a programas educacionais que são reduzidos a um treinamento. O texto se encerra analisando os impactos deste cenário para a realidade brasileira (periférica e dependente) e busca indicar caminhos para a resistência.
The importance of adhering to regulations in healthcare: lessons from the COVID-19 pandemic and historical incidents
Authors: Winter George
Published: March 2023

George Winter discusses the importance of following healthcare rules, regulations and guidance within healthcare, using both COVID-19 and historical cases to demonstrate this
Are opioids being over-prescribed in gynaecology surgery?
Authors: Howe Emma , Metwally Mostafa
Published: March 2023

Although opioids are highly effective in managing post-operative pain, patients undergoing surgical procedures are at risk of developing a new persistent opioid. Concerns regarding the volume of patients on long-term opioids in our region prompted a service evaluation to review take-home post-operative opioid prescriptions in gynaecology surgical patients. Results showed an average duration of opioid prescription of 7.9 days and longer durations of take-home opioid prescriptions in the laparoscopy group compared to the laparotomy group (8.6 vs 7.1 days), despite lower inpatient opioid consumption in these groups (10.2 mg vs 17.0 mg morphine equivalent daily dose). Previous studies have quantified patients' post-operative opioid consumption and demonstrated effective use of restrictive opioid regimes. The unit described is prescribing more than has been demonstrated to be consumed and therefore required. As the duration of opioid use is recognised as the strongest predictor of future opioid misuse, an opioid duration limit of 3 days is suggested.
How to complete a safe and effective contraceptive consultation
Authors: Nicol Claire
Published: March 2023

The contraceptive consultation should focus on the provision of safe, effective contraception that suits the individual's requirements. It is important to take a comprehensive medical and drug history to ensure that the chosen method is safe for the individual at both initiation and review consultations. A review consultation is a good opportunity to discuss other – often more effective – methods of contraception. Remote contraceptive consultations are suitable for many patients, as long as the same high standards of care are provided as they would be in a face-to-face consultation. Nurses offering contraceptive services should ensure they keep up to date with the latest clinical guidance.
Handling parental disagreements
Authors: Mounsey Heidi
Published: March 2023

A common query to the Medical Protection advice line is how to manage requests for medical information about a child with separated parents. Dr Heidi Mounsey sets out some underlying principles that are usually applicable to most cases
İran Merkezi Bölgesi Türklerinde Ağaç Kültü
Authors: GÜN Faruk , KASIMHANİ İhsan
Published: March 2023

Türk kültürü ve eski Türk inanışında tabiat kültleri içinde bulunan ve Orhun Abidelerinde kutsal yer su şeklinde geçen ağaç, kutsalların mekânı olması, evrenin merkezinde bulunması ve Türeyiş efsanelerine konu edilmesi nedenleriyle geçmişten günümüze Türk kültüründe önemli bir öge olarak varlığını sürdürmüştür. Ağaç kültü, sadece Türk inanç sistemi ile Türk mitolojisindeki hususlarıyla değil, ölümsüzlüğü ve yeniden doğuşu simgelemesi, verimli oluşu ve kutsallığı yönleriyle insanlar üzerinde psikolojik tesirler bırakmıştır. Söz konusu etki, çeşitli memoratlar yoluyla günümüze de aktarılmıştır. Bu sebeple Türk coğrafyalarında olduğu gibi İran sahası Merkezi bölgesindeki Türkler arasında da uygulanan ritüel ve pratiklerle kült olma özelliğini sürdürmüştür. Araştırmada Merkezi bölgesindeki ağaç kültünün Türk inanç dünyasındaki yeri üzerinde durulduktan sonra kutsal ağaçlar etrafında oluşan uygulama ve pratikler ile geçmişten günümüze kutsal kabul edilen ağaçlar ele alınacaktır. Araştırmada kullanılan veriler, 2019 yılında bölgedeki sözlü kaynaklardan toplanan folklorik malzemelerden oluşmaktadır. Araştırma, Merkezi bölgesinde hem önceki yıllarda varlığını belli bir süre korumuş ancak çeşitli nedenlerden dolayı kesilmiş, yakılmış ağaçlarla hem de bölgede hâlâ varlığını sürdüren ağaçlarla sınırlandırılmıştır. Bölgenin ağaç kültüyle ilgili güncel bir bilginin bulunmaması, Merkezi bölgesinde konuyla ilgili bütüncül bir çalışmanın zaruretini doğurmuştur. Araştırma neticesinde Merkezi bölgesindeki Türkler arasında varlığını koruyan ağaç kültünün farklı Türk coğrafyalarındaki ağaç kültleri ile gerek fikrî yönde gerekse de pratik ve uygulamalar noktasında benzerlikler taşıdığı tespit edilmiştir.
Supplemental data for "Impacts on Teamwork Performance for an Engineering Capstone in Emergency Remote Teaching"
Authors: Brown Brandi , Fudolig Miguel , Keshwani Deepak , Brown-Brandl Tami M.
Published: March 2023

Tables containing detailed results of statistical data analysis as additional supplementary material to complement the results presented in the research article.
USE OF A MULTI-CRITERIA DECISION SUPPORT MODEL BASED ON THE AHP METHOD FOR THE SELECTION OF HEALTH INFRASTRUCTURE PROJECTS
Authors: Akhrouf Mohamed , Derghoum Mahfoudh
Published: March 2023

This article aims to develop a methodology in which alternative projects are prioritized and selected using appropriate methods of multi-criteria decision-making in organizations responsible for managing and developing health infrastructure. This study addresses a particular gap in implementing a systematic methodology for prioritizing and selecting projects in the health sector. The methodology developed proposes an approach based on the AHP multi-criteria decision support method for decision-makers and stakeholders to prioritize and select projects in the health sector. The problem was modeled using the Expert Choice software which allows a good “integration of the decision-maker” in the decision-making process making it possible to intervene in the research and decisions to identify the most efficient and potentially profitable health projects that are useful to the community.
Optical axis-driven tunable Brewster effect in anisotropic materials
Authors: Liu Haotuo , Yu Kun , Zhang Kaihua , Ai Qing , Xie Ming , Wu Xiaohu
Published: March 2023

The Brewster effect, which is known as a notable physical law, has
promising prospects in perfect absorption and angular selectivity
transmission. The Brewster effect in isotropic materials has been
investigated extensively in previous works. However, the research on
anisotropic materials has been rarely carried out. In this work, we
theoretically investigate the Brewster effect in quartz crystals with
tilted optical axes. The conditions for the occurrence of the Brewster
effect in anisotropic materials are derived. The numerical results
show that by changing the orientation of the optical axis, we have
effectively regulated the Brewster angle of crystal quartz. The
reflection of crystal quartz versus the wavenumber and incidence angle
at different tilted angles is studied. In addition, we discuss the
effect of the hyperbolic region on the Brewster effect of crystal
quartz. The Brewster angle negatively correlates with
the tilted angle when the wavenumber is 460cm−1 (Type-II). In contrast, when the
wavenumber is 540cm−1 (Type-I), the Brewster angle
positively correlates with the tilted angle. Finally, the relationship
between the Brewster angle and wavenumber at different
tilted angles is investigated. The findings in this work will broaden
the research field of crystal quartz and open the door for tunable
Brewster devices based on anisotropic materials.
Inferring incompetence from employment status: An audit-like experiment
Authors: Okoroji Celestin , Gleibs Ilka H. , Howard Simon
Published: March 2023

Audit studies demonstrate that unemployed people are less likely to receive a callback when they apply for a job than employed candidates, the reason for this is unclear. Across two experiments (N = 461), we examine whether the perceived competence of unemployed candidates accounts for this disparity. In both studies, participants assessed one of two equivalent curriculum vitae’s, differing only on the current employment status. We find that unemployed applicants are less likely to be offered an interview or hired. The relationship between the employment status of the applicant and these employment-related outcomes is mediated by the perceived competence of the applicant. We conducted a mini meta-analysis, finding that the effect size for the difference in employment outcomes was d = .274 and d = .307 respectively, while the estimated indirect effect was -.151[-.241, -.062]. These results offer a mechanism for the differential outcomes of job candidates by employment status.
Effectiveness of nordic walking in patients with asthma: A study protocol of a randomized controlled trial
Authors: Vilanova-Pereira María , Jácome Cristina , Rial Prado Manuel Jorge , Barral-Fernández Margarita , Blanco Aparicio Marina , Fontán García-Boente Lara , Lista-Paz Ana
Published: March 2023

Background

Patients with asthma often consider their symptomatology a barrier to exercise, leading to a reduced physical activity level. This study aims to determine whether the effect of a Nordic walking (NW) training program plus education and usual care is superior to educational and usual care only, in terms of exercise tolerance and other health-related outcomes in patients with asthma. The second aim is to explore the patients’ experience with the NW program.

Methods

A randomized controlled trial will be conducted with 114 adults with asthma recruited in sanitary area of A Coruña, Spain. Participants will be randomized to NW or control groups in blocks of six and in the same proportion in each group. Participants in the NW group will enrol in supervised sessions during eight weeks, three times/week. All participants will receive three educational sessions on asthma self-management plus usual care (S1 Appendix). Outcomes such as exercise tolerance (primary outcome), physical activity level, asthma-related symptoms and asthma control, dyspnea, lung function, handgrip strength, health related quality of life, quality of sleep, treatment adherence and healthcare resources use will be measured pre and postintervention, and at three and six months of follow-up. Participants in the NW group will additionally participate in focus groups.

Discussion

This is the first study analysing the effect of NW in patients with asthma. NW combined with education and usual care is expected to improve exercise tolerance, but also asthma-related outcomes. If this hypothesis is confirmed, a new community-based therapeutic approach will be available for patients with asthma.

Trial registration

Study registered in ClinicalTrials.gov with number of register NCT05482620.
Contactin-1 links autoimmune neuropathy and membranous glomerulonephritis
Authors: Fehmi Janev , Davies Alexander J. , Antonelou Marilina , Keddie Stephen , Pikkupeura Sonja , Querol Luis , Delmont Emilien , Cortese Andrea , Franciotta Diego , Persson Staffan , Barratt Jonathan , Pepper Ruth , Farinha Filipa , Rahman Anisur , Canetti Diana , Gilbertson Janet A. , Rendell Nigel B. , Radunovic Aleksandar , Minton Thomas , Fuller Geraint , Murphy Sinead M. , Carr Aisling S. , Reilly Mary R. , Eftimov Filip , Wieske Luuk , Teunissen Charlotte E. , Roberts Ian S. D. , Ashman Neil , Salama Alan D. , Rinaldi Simon
Published: March 2023

Membranous glomerulonephritis (MGN) is a common cause of nephrotic syndrome in adults, mediated by glomerular antibody deposition to an increasing number of newly recognised antigens. Previous case reports have suggested an association between patients with anti-contactin-1 (CNTN1)-mediated neuropathies and MGN. In an observational study we investigated the pathobiology and extent of this potential cause of MGN by examining the association of antibodies against CNTN1 with the clinical features of a cohort of 468 patients with suspected immune-mediated neuropathies, 295 with idiopathic MGN, and 256 controls. Neuronal and glomerular binding of patient IgG, serum CNTN1 antibody and protein levels, as well as immune-complex deposition were determined. We identified 15 patients with immune-mediated neuropathy and concurrent nephrotic syndrome (biopsy proven MGN in 12/12), and 4 patients with isolated MGN from an idiopathic MGN cohort, all seropositive for IgG4 CNTN1 antibodies. CNTN1-containing immune complexes were found in the renal glomeruli of patients with CNTN1 antibodies, but not in control kidneys. CNTN1 peptides were identified in glomeruli by mass spectroscopy. CNTN1 seropositive patients were largely resistant to first-line neuropathy treatments but achieved a good outcome with escalation therapies. Neurological and renal function improved in parallel with suppressed antibody titres. The reason for isolated MGN without clinical neuropathy is unclear. We show that CNTN1, found in peripheral nerves and kidney glomeruli, is a common target for autoantibody-mediated pathology and may account for between 1 and 2% of idiopathic MGN cases. Greater awareness of this cross-system syndrome should facilitate earlier diagnosis and more timely use of effective treatment.
Effects of β-caryophyllene and oxygen availability on cholesterol and fatty acids in breast cancer cells
Authors: Frost Christopher J. , Ramirez-Mata Andrea , Khattri Ram B. , Merritt Matthew E. , Frost Susan C.
Published: March 2023

Hypoxia is a common feature of most solid tumors, one that favors tumor progression and limits treatment effectiveness. Targeting hypoxia has long been a goal in cancer therapy, by identifying factors that reverse or ameliorate the effects of hypoxia on cancer cells. We, and others, have shown that β-caryophyllene (BCP) exhibits anti-proliferative properties in cancer cells. We have further shown that non-cytotoxic concentrations of BCP affect cholesterol and lipid biosynthesis in hypoxic hBrC cells at both transcriptional and translational levels. This led us to hypothesize that BCP may reverse the hypoxic phenotype in hBrC cells. To test this, we determined the effect of BCP on hypoxic sensitive pathways, including oxygen consumption, glycolysis, oxidative stress, cholesterol and fatty acid biosynthesis, and ERK activation. While each of these studies revealed new information on the regulation by hypoxia and BCP, only the lipidomic studies showed reversal of hypoxic-dependent effects by BCP. These later studies showed that hypoxia-treated samples lowered monounsaturated fatty acid levels, shifting the saturation ratios of the fatty acid pools. This signature was ameliorated by sub-lethal concentrations of BCP, possibly through an effect on the C:16 fatty acid saturation ratios. This is consistent with BCP-induced upregulation of the stearoyl-CoA desaturase (SCD) gene, observed previously. This suggests that BCP may interfere with the lipid signature modulated by hypoxia which could have consequences for membrane biosynthesis or composition, both of which are important for cell replication.
Settlement dynamics, subsistence economies and climate change during the late Holocene at Nunura Bay (Sechura Desert, Peru): A multiproxy approach
Authors: Villa Valentina , Bermeo Nicolas , Zazzo Antoine , Lefèvre Christine , Béarez Philippe , Correa Denis , Dufour Elise , Manin Aurélie , Dausse Lucie , Gutiérrez Belkys , Vásquez Segundo , Christol Aurélien , Bahain Jean-Jacques , Goepfert Nicolas
Published: March 2023

Long considered on the margins, far from the major cultural traditions, the Sechura Desert is situated at the crossroads between the cultures of southern Ecuador and those of the northern Peruvian coast and preserves a large number of varied archaeological sites. Despite this evidence, little is known about the societies that inhabited this region during the Holocene. Exposed to natural hazards, including El Niño events, and to major climatic changes, they were able to adapt and exploit the scarce resources that this extreme environment offered them. Because of this rich history, we have been conducting archaeological research in this region since 2012 in order to clarify the dynamics of human occupation and their links with climate oscillations and environmental changes. This paper present the results of a multidisciplinary study of Huaca Grande, a mound located on Nunura Bay, 300 m from the Pacific Ocean. The nature of the human occupations at Huaca Grande was varied, and several adjustments occurred over time. The subsistence economy was based mainly on local marine resources and a continual use of terrestrial vegetal resources. However, a major change occurred in the more recent occupations, with the apparition of non-local resources (maize and cotton) indicating that Huaca Grande was connected to trade networks. The results show two main phases of occupation separated by a long abandonment (mid-5th century CE to mid-7thcentury CE and mid-13th century to mid-15th century CE). The occupation of the site appears to have been influenced by changes in the local climate and by extreme El Niño events. Our results highlight the great adaptability of these human groups over the span of a millennium and their capacity to react to the climatic changes and hazards that characterise this region.
Designing an exploratory phase 2b platform trial in NASH with correlated, co-primary binary endpoints
Authors: Meyer Elias Laurin , Mesenbrink Peter , Di Prospero Nicholas A. , Pericàs Juan M. , Glimm Ekkehard , Ratziu Vlad , Sena Elena , König Franz ,   on behalf of the EU-PEARL NASH Investigators
Published: March 2023

Non-alcoholic steatohepatitis (NASH) is the progressive form of nonalcoholic fatty liver disease (NAFLD) and a disease with high unmet medical need. Platform trials provide great benefits for sponsors and trial participants in terms of accelerating drug development programs. In this article, we describe some of the activities of the EU-PEARL consortium (EU Patient-cEntric clinicAl tRial pLatforms) regarding the use of platform trials in NASH, in particular the proposed trial design, decision rules and simulation results. For a set of assumptions, we present the results of a simulation study recently discussed with two health authorities and the learnings from these meetings from a trial design perspective. Since the proposed design uses co-primary binary endpoints, we furthermore discuss the different options and practical considerations for simulating correlated binary endpoints.
Target-enriched enzymatic methyl sequencing: Flexible, scalable and inexpensive hybridization capture for quantifying DNA methylation
Authors: Rubenstein Dustin R. , Solomon Joseph
Published: March 2023

The increasing interest in studying DNA methylation to understand how traits or diseases develop requires new and flexible approaches for quantifying DNA methylation in a diversity of organisms. In particular, we need efficient yet cost-effective ways to measure CpG methylation states over large and complete regions of the genome. Here, we develop TEEM-Seq (target-enriched enzymatic methyl sequencing), a method that combines enzymatic methyl sequencing with a custom-designed hybridization capture bait set that can be scaled to reactions including large numbers of samples in any species for which a reference genome is available. Using DNA from a passerine bird, the superb starling (Lamprotornis superbus), we show that TEEM-Seq is able to quantify DNA methylation states similarly well to the more traditional approaches of whole-genome and reduced-representation sequencing. Moreover, we demonstrate its reliability and repeatability, as duplicate libraries from the same samples were highly correlated. Importantly, the downstream bioinformatic analysis for TEEM-Seq is the same as for any sequence-based approach to studying DNA methylation, making it simple to incorporate into a variety of workflows. We believe that TEEM-Seq could replace traditional approaches for studying DNA methylation in candidate genes and pathways, and be effectively paired with other whole-genome or reduced-representation sequencing approaches to increase project sample sizes. In addition, TEEM-Seq can be combined with mRNA sequencing to examine how DNA methylation in promoters or other regulatory regions is related to the expression of individual genes or gene networks. By maximizing the number of samples in the hybridization reaction, TEEM-Seq is an inexpensive and flexible sequence-based approach for quantifying DNA methylation in species where other capture-based methods are unavailable or too expensive, particularly for non-model organisms.
Semi-supervised atmospheric component learning in low-light image problem
Authors: Fahim Masud An Nur Islam , Saqib Nazmus , Jung Ho Yub
Published: March 2023

Ambient lighting conditions play a crucial role in determining the perceptual quality of images from photographic devices. In general, inadequate transmission light and undesired atmospheric conditions jointly degrade the image quality. If we know the desired ambient factors associated with the given low-light image, we can recover the enhanced image easily. Typical deep networks perform enhancement mappings without investigating the light distribution and color formulation properties. This leads to a lack of image instance-adaptive performance in practice. On the other hand, physical model-driven schemes suffer from the need for inherent decompositions and multiple objective minimizations. Moreover, the above approaches are rarely data efficient or free of postprediction tuning. Influenced by the above issues, this study presents a semisupervised training method using no-reference image quality metrics for low-light image restoration. We incorporate the classical haze distribution model to explore the physical properties of the given image to learn the effect of atmospheric components and minimize a single objective for restoration. We validate the performance of our network for six widely used low-light datasets. Experimental studies show that our proposed study achieves a competitive performance for no-reference metrics compared to current state-of-the-art methods. We also show the improved generalization performance of our proposed method which is efficient in preserving face identities in extreme low-light scenarios.
The distribution of different intensity demanding scenarios in elite rink hockey players using an electronic performance tracking system
Authors: Fernández Daniel , Cadefau Joan A. , Serra Noemí , Carmona Gerard
Published: March 2023

Despite the traditional use of average values for determining physical demands, the intermittent and fluctuating nature of team sports may lead to underestimation of the most demanding scenarios. All the most demanding scenario-related investigations to date only report one maximal scenario per game, the greatest. However, the latest research on this subject has shown additional scenarios of equal or similar magnitude that most researchers have not considered. This repetition concept started a new way of describing competition and training loads; then the study aims were: first, to quantify and assess differences between playing positions in terms of the most demanding scenarios in official matches; and second, to quantify and assess the differences between playing positions in the repetition of different intensity scenarios relative to the most demanding individual scenario. We monitored nine professional rink hockey players (7 exterior and 2 interior players) in 18 competitive matches using an electronic performance tracking system. The interior players are closest to the opponent’s goal, while the exterior players are farthest from it. Peak physical demands variables included total distance (m), distance covered at >18 km·h-1 (m), the number of accelerations (≥2 m∙s-2, count) and decelerations (≤-2 m∙s-2, count) in 30 s. An average from the top three individual most demanding scenarios was used to define a reference value to quantify the distribution scenario repetition during matches. The results showed that peak demands in rink hockey are position-dependent, with more distance covered by exterior players and more accelerations performed by interior players. In addition, rink hockey matches include multiple scenario exposures that are close to the peak physical demands of a match. Using the results of this study, coaches can prepare tailored training plans for each position, focusing on distances covered or accelerations for exterior players.
Targeting nonsense-mediated RNA decay does not increase progranulin levels in the Grn R493X mouse model of frontotemporal dementia
Authors: Smith Denise M. , Niehoff Michael L. , Ling Karen , Jafar-Nejad Paymaan , Rigo Frank , Farr Susan A. , Wilkinson Miles F. , Nguyen Andrew D.
Published: March 2023

A common cause of frontotemporal dementia (FTD) are nonsense mutations in the progranulin (GRN) gene. Because nonsense mutations activate the nonsense-mediated RNA decay (NMD) pathway, we sought to inhibit this RNA turnover pathway as a means to increase progranulin levels. Using a knock-in mouse model harboring a common patient mutation, we tested whether either pharmacological or genetic inhibition of NMD upregulates progranulin in these GrnR493X mice. We first examined antisense oligonucleotides (ASOs) targeting an exonic region in GrnR493X mRNA predicted to block its degradation by NMD. As we previously reported, these ASOs effectively increased GrnR493X mRNA levels in fibroblasts in vitro. However, following CNS delivery, we found that none of the 8 ASOs we tested increased Grn mRNA levels in the brains of GrnR493X mice. This result was obtained despite broad ASO distribution in the brain. An ASO targeting a different mRNA was effective when administered in parallel to wild-type mice. As an independent approach to inhibit NMD, we examined the effect of loss of an NMD factor not required for embryonic viability: UPF3b. We found that while Upf3b deletion effectively perturbed NMD, it did not increase Grn mRNA levels in Grn+/R493X mouse brains. Together, our results suggest that the NMD-inhibition approaches that we used are likely not viable for increasing progranulin levels in individuals with FTD caused by nonsense GRN mutations. Thus, alternative approaches should be pursued.
Determinants of COVID-19 vaccine hesitancy among students and parents in Sentinel Schools Network of Catalonia, Spain
Authors: Ganem Fabiana , Folch Cinta , Colom-Cadena Andreu , Bordas Anna , Alonso Lucia , Soriano-Arandes Antoni , Casabona Jordi ,   on behalf of Sentinel School Network Study Group of Catalonia
Published: March 2023

Vaccine hesitancy is defined as a delay in acceptance of vaccines despite its availability, caused by many determinants. Our study presents the key reasons, determinants and characteristics associated with COVID-19 vaccine acceptability among students over 16 years and parents of students under 16 years and describe the COVID-19 vaccination among students in the settings of sentinel schools of Catalonia, Spain. This is a cross-sectional study that includes 3,383 students and the parents between October 2021 and January 2022. We describe the student’s vaccination status and proceed a univariate and multivariate analysis using a Deletion Substitution Addition (DSA) machine learning algorithm. Vaccination against COVID-19 reached 70.8% in students under 16 years and 95.8% in students over 16 years at the end of the study project. The acceptability among unvaccinated students was 40.9% and 20.8% in October and January, respectively, and among parents was proportionally higher among students aged 5–11 (70.2%) in October and aged 3–4 (47.8%) in January. The key reason to not vaccinate themselves, or their children, were concern about side effects, insufficient research about the effect of the vaccine in children, rapid development of vaccines, necessity for more information and previous infection by SARS-CoV-2. Several variables were associated with refusal end hesitancy. For students, the main ones were risk perception and use of alternative therapies. For parents, the age of students, sociodemographic variables, socioeconomic impact related to the pandemic, and use of alternative therapies were more evident. Monitoring vaccine acceptance and refusal among children and their parents has been important to understand the interaction between different multilevel determinants and we hope it will be useful to improve public health strategies for future interventions in this population.
Breaking the cycle: A sustainable fashion paradigm
Authors: Demirdjian Alyson Rae , Orzada Belinda T.
Published: March 2023

The fashion system fundamentally changed during the Industrial Revolution when the industry pivoted away from traditional craft-based production and towards mechanization and mass production. The design process, manufacturing operations, retail practices and marketing tactics of mass production contributed over time to the current climate crisis. Globally, the fashion system is acknowledged as an environmental and social emergency. Thus, the fashion system needs to get with the times. Fashion as a reflection of modernity needs to align with globally recognized social and environmental goals. Societal attachment to materialism and fashion consumption should be reconsidered. In this article we consider these challenges to propose a paradigm that breaks the fashion cycle and provides a framework for the role fashion producers and consumers should play in the twenty-first century.
Általános célú neurális hálózat tesztelése különböző adatbázisokon
Authors: Benkő-Kiss Árpád , Fabulya Zoltán , Hampel György
Published: March 2023

Két rejtett réteget tartalmazó, előrecsatolt, teljes összeköttetésű neurális hálózatot teszteltünk több adatbázison. A teszt célja, hogy az adott rendszer milyen hibaszázalékkal képes az input adatokból a várható értékeket előre jelezni, és alkalmas-e gyakorlati feladatok előrejelzésére. A Python scriptnyelven fejlesztett grafikus felülettel rendelkező rendszer rugalmasan paraméterezhető, mind a hálózat mérete, struktúrája változtatható, tehát adaptálható különböző méretű adatbázisok vizsgálatára.
Innováció a szoftvertesztelésben – Megoldás-e az automatizálás?
Authors: Béli Marcell , Tóth Fanni , Varga Tamás
Published: March 2023

A tanulmány célja az automatizált szoftvertesztelés elméleti és gyakorlati hatékonyságának vizsgálata. Ehhez felmérjük, milyen szempontok szerint érdemes automatizált tesztelői szoftvert választani, valamint rávilágítunk, milyen esetekben hatékonyabb az automatizált tesztelés a manuális teszteléssel szemben. Előbb elméleti síkon vetjük össze a két tesztelési módszertant, majd egy valós üzleti esettanulmányon keresztül mutatjuk be a tesztelői szoftver kiválasztását és végzünk el egy gyakorlati összehasonlító elemzést. Öt automata tesztrendszer összehasonlítása alapján kiderül, hogy az alapvető technológiai és gazdasági követelményeken felül a rugalmasság és a megbízhatóság is kiemelkedő szempont a kiválasztási folyamatban. A tanulmányból kiderül az is, hogy az automatizálás csak ismétlődő tesztelések esetén lehet hatékony. Egy legalább tíz ügyféllel rendelkező szoftvergyártónak azonban megéri az automatizált tesztelés irányába mozdulni.
A munkavállalók személyiségtípusának kapcsolata a vezetővel szembeni elvárásaikkal
Authors: Tóth Szimonetta , Kozák Anita
Published: March 2023

A tanulmány arra a kérdésre keresi a választ, hogy van-e kapcsolat a munkavállalók személyiségvonásai és a vezetőjükkel szembeni elvárásaik között. Annak érdekében, hogy a dolgozók személyiségtípusa és az előnyben részesített vezetési stílus közötti kapcsolatokat feltárjuk, kérdőíves megkérdezést végeztünk. A kérdőív kérdéseit validált mérőeszközök alapján fogalmaztuk meg, az item-ek a Big Five személyiségmodellhez, a Lewin-féle autokratikus, demokratikus és laissez-faire (ráhagyó) vezetési stílusokhoz, valamint az etikus, a karizmatikus és a transzformációs vezetéshez kapcsolódnak. A mintavételhez hólabda módszert alkalmaztunk, összesen 113 fő töltötte ki a kérdőívet; a kapott eredményekből tehát általános következtetések nem vonhatók le, azok csak a vizsgált halmazra igazak. A kapott adatokat SPSS program segítségével elemeztük, Spearman-féle rangkorrelációs vizsgálatokat és nem-paraméteres teszteket (Mann-Whitney és Kruskal-Wallis) végeztünk. Az eredményeink rávilágítottak arra, hogy a dolgozók szocio-demográfiai jellemzői, valamint személyiségjegyeik és vezetővel szembeni elvárásik között kapcsolat van. Részletező elemzéseink alapján az is kiderült, hogy a válaszadók lelkiismeretességének, neuroticizmusának és tapasztalatokra való nyitottságának mértéke, valamint a vezetővel szembeni elvárásaik között is összefüggések mutathatók ki.
Simulation of Heterogeneously-Catalyzed Non-Isothermal Reactive Flow in Industrial Packed Beds
Authors: Hlavatý T. , Isoz M. , Khýr M.
Published: March 2023

Packed bed reactors are the most frequently used devices to perform heterogeneously catalyzed reactions on industrial scales. An industrial real-life heterogeneous catalysis is complex process that combines fully three-dimensional mass, momentum and energy transport on several scales. In the present work, we leverage our previously developed CFD solver for non-isothermal heterogeneously catalyzed reactive flow based on the finite volume method and couple it with our in-house DEM-based method for preparation of random packed beds. The resulting framework is verified in the simplified cases against available analytical solutions and correlations and is used to study an industrially-relevant case of ethylene oxychlorination performed in a tubular packed bed comprising CuCl₂-coated catalyst carrying particles. In particular, we compare properties of three different industrially used catalyst carrying particles: Raschig rings, Reformax, and Wagon wheels.
Calculation of a Ventilated Cavity in OpenFOAM
Authors: Koval S. O. , Dimitrieva N. F. , Voropaiev G. O.
Published: March 2023

In this paper the formation of a cavity behind a streamlined body under the regime of air injection into a water flow in the gravity field is studied. Mathematical modeling is based on the Volume of Fluid method. The determining system of equations for the water-air mixture consists of the Navier-Stokes equation, continuity, conservation of energy, and phase transport equation. Numerical modeling was performed using OpenFOAM for two-phase flow of two compressible fluids without a phase change. The results of calculations are presented for an air cavity behind a disk cavitator. The influence of physical parameters on the size and stability of cavity was investigated. Good agreement with experimental data was obtained.
On the Development of a Numerical Model for the Simulation of Air Flow in the Human Airways
Authors: Lancmanová A. , Bodnár T. , Sequeira A.
Published: March 2023

This contribution reports on an ongoing study focusing on reduced order models for incompressible viscous fluid flow in two dimensional channels. A finite difference solver was developed using a simple implementation of the immersed boundary method to represent the channel geometry. The solver was validated for unsteady flow by comparing the obtained two-dimensional numerical solutions with analytical profiles computed from the Womersley solution. Finally the 2D model was coupled to a simple 1D extension simulating the flow in axisymmetric elastic vessel (tube). Some of the coupling principles and implementation issues are discussed in detail.
Marcação/não marcação das formas de tratamento tú, vos e usted via planos discursivos
Authors: Pontes Valdecy Oliveira , Silva Ricardo Freire da
Published: March 2023

O objetivo deste artigo é o de apresentar uma análise funcional, em peças teatrais, do começo do século XX, aplicada ao percentual de frequência de uso das formas de tratamento tú, vos e usted no espanhol argentino e uruguaio, com foco nos planos discursivos (figura, fundo 1 e 2) e no princípio funcional da marcação. Para esta pesquisa, utilizou-se como referencial teórico, os estudos de Givón (1990, 1991, 1995), Hopper (1979), Hopper e Thompson (1980) e Chedier (2007). Em relação aos resultados, nas peças argentinas, para figura, a forma vos apresentou um percentual de 49,38%. Por outro lado, para fundo 1 e fundo 2, no uso de usted, obteve-se 46,15% e 67,83%, respectivamente. No caso do Uruguai, ocorreu o predomínio da forma tú, nos três planos discursivos, com 66,02% para figura, 100% para fundo 1, e 85,71% para fundo 2. Espera-se, com este estudo, contribuir para ampliar as discussões sobre as formas de tratamento e os planos discursivos, pelo viés funcional, e, assim, oportunizar novas possibilidades de análise e possíveis desdobramentos de cunho teórico-analítico.
Central mucoepidermoid carcinoma of the maxilla, a challenging diagnosis
Authors: Sibille Louis , Olszewski Raphael , Magremanne Michele
Published: March 2023

Objective: To present a pictorial review on central mucoepidermoid carcinoma.

Case report: Central mucoepidermoid carcinoma (CMEC), also known as intraosseous mucoepidermoid carcinoma (IMEC), is an extremely rare disease (less than 2-4% of all MEC). However, CMEC is the most frequent malignant salivary gland tumour found in intraosseous locations. Due to this unusual location, diagnosis of CMEC can be challenging. Therefore, CMEC is often mistaken for other intraosseous or odontogenic pathologies. Radiological assessment shouldinclude panoramic X-Ray, CBCT  and thoracic CT, which should be performed after diagnosis. The recommended treatment includes radical resection surgery, followed by radiotherapy if indicated. A long-term follow-up is recommended for up to 10 years.

Conclusion: The authors experienced the challenging diagnosis of CMEC through the case of a patient who presented with a slowly growing palatal mass.
Sustainable digitalization ‐ fostering the twin transformation in a transdisciplinary way
Authors: Barth Matthias , Gossen Maike , Lang Daniel J. , Santarius Tilman
Published: March 2023

Can digitalization be designed in such a way that it does not harm the environment or promote unsustainable lifestyles? Can it even promote a green transformation? The authors of this GAIA special issue discuss how stakeholder engagement and transdisciplinary approaches can help
address digitalization and sustainability in an integrated way. The special issue deepens insights into the state of knowledge on sustainable digitalization in both scientific and political discourses.