bluuebunny/crossref_metadata_2025 huggingface dataset:
3D CFD model for the analysis of the flow field through a horizontal axis wind turbine (HAWT)
Authors: Menasri Noureddine , Zergane Said , Aimeur Noureddine , Amour Aissa
Published: September 2023

With the world’s growing demand for energy, renewable energy production has become important in providing alternative sources of energy and in reducing the greenhouse effect. This study investigates the aerodynamics and performance of the WG/EV100 micro–Horizontal Axis Wind Turbine (HAWT) using Computational Fluid Dynamics (CFD). The complexity of VAWT aerodynamics, which is inherently unsteady and three-dimensional, makes high-fidelity flow models extremely demanding in terms of computational cost, limiting the analysis to mainly 2D Computational Fluid-Dynamics (CFD) approaches. This article explains how to perform a full 3D unsteady CFD simulation of HAWT. All main parts of the WG/EV100 HAWT were designed in SOLIDWORKS. Only the blade design was reverse engineered due to the unavailability of the CAD model and the complexity of its geometric characteristics. The impeller blade is scanned using a Coordi-nate Measuring Machine (CMM), and the obtained 3D scan data are exported from the PC-DMIS software to GEOMAGIC design X to obtain a CAD model of the blade.
Shock wave configuration in a transonic flow through a mid-section of a last stage turbine blade cascade equipped with a part-span connector
Authors: Radnic Tomáš , Šafařík Pavel , Luxa Martin , Šimurda David
Published: September 2023

This paper deals with the study of a flow field and namely the configuration of shock waves in a blade cascade equipped with a part-span connector called tie-boss. The cascade consists of prismatic blades formed from the mid-section of a very long last-stage blade of a steam turbine. The study is based on numerical simulations of the flow through a cascade that was previously tested in a wind tunnel. Commercial software Ansys CFX was used for the simulations and Ansys ICEM for the mesh generation. The computational domain contains non-homogenous mesh interfaces. The simulations showed that the presence of the tie-boss has a profound effect on the configuration of the shock waves. The blade exit shock waves are disturbed and new lateral shock waves are introduced into the flow.
Construction of angular-dependent potentials from trigonometric Pöschl-Teller systems within the Dunkl formalism
Authors: Schulze-Halberg Axel
Published: September 2023

We generate solvable cases of the two angular equations resulting from variable separation in the three-dimensional Dunkl-Schrödinger equation expressed in spherical coordinates. It is shown that the Dunkl formalism interrelates these angular equations with trigonometric Pöschl-Teller systems. Based on this interrelation, we use point transformations and Darboux-Crum transformations to construct new solvable cases of the angular equations. Instead of the stationary energy, we use the constants due to the separation of variables as transformation parameters for our Darboux-Crum transformations.
Leuchtendes Löffeln in Leipzig. Design als kulturelle Praxis im öffentlichen Raum.
Authors: Meier Stefan
Published: September 2023

Zusammenfassung. Der vorliegende Beitrag diskutiert die gesellschaftliche Funktion von Design als öffentlicher wahrnehmbarer Zeichenpraxis und verdeutlicht, inwiefern Designobjekte ihre Funktion und Bedeutung durch Handlungs- und Diskurskontexte erhalten. Ihre Zeichenhaftigkeit wird hierdurch von einer vermeintlichen Deutungsoffen­heit auf konkrete Bedeutungspotenziale reduziert. Kulturelle und soziale Kontexte schaf­fen im interpretativen Zusammenspiel mit Materie, Farbe und Form Identität, die sich auf der Ausdrucksebene in Form von Stil darstellt. Stil stellt sich somit im schöpferischen Akt durch Stil-Praktiken her, die sich als Auswahl, Formung und Komposition von semiotischen Ressourcen bestimmen lassen. Exemplarisch verdeutlicht werden diese Praktiken anhand einer aus den 1970er Jahren stammenden, unter Denkmalschutz ste­henden Leuchtreklame, der sogenannten „Leipziger Löffelfamilie“.
Tahrir Is Not a Square. Wie meta-urbane Protestkommunikate städtische Territorien des Widerspruchs strukturieren.
Authors: Warnke Ingo H.
Published: September 2023

Zusammenfassung. Schrift im öffentlich zugänglichen Raum der Stadt ist ein wichtiger soziolinguistischer Forschungsgegenstand. Aufschriften aller Art prägen nicht nur den urbanen Raum, sondern bringen spezifische Orte erst hervor. Im Zentrum der Analyse steht die Konstruktion eines urbanen Protestraums, wie er durch sogenannte Protest­kommunikate hervorgebracht wird. Beispiel ist dabei ein Stencil, das auf den Tahrir-Platz in Kairo zu verweisen scheint, das jedoch über interspatiale, interdiskursive und inter­mediale Bezüge weit mehr leistet. Es ist Teil einer Ortsassoziation, die den urbanen Raum als Territorium des Widerspruchs beschreibbar macht. Der Beitrag leistet einer­seits eine ethnographische Detailanalyse zu einem Schriftvorkommen in Berlin Prenz­lauer Berg, er gibt darüber hinaus aber vor allem auch Hinweise auf Möglichkeiten einer soziolinguistischen und semiotischen Analyse urbaner Widerspruchsterritorien überhaupt.
Phonetische Transkription als folklinguistische Zeichen-Praxis im öffentlichen Raum
Authors: Heyd Theresa
Published: September 2023

Zusammenfassung. Diese Studie ist eine erste Erkundung von laienlinguistischer Nutzung phonetischer Transkription im öffentlichen Raum. Dabei handelt es sich um Gebrauchsformen, bei denen das semiotische Repertoire der Transkription – beispiels­weise phonetische Symbole und die Klammerung von Lexemen, aber auch Silben­trennung und lexikografische Textstruktur – in der digitalen oder materiellen Öffent­lichkeit in einen dekontextualisierten Zusammenhang gebracht wird. Damit verbindet sich ein intendierter Effekt, der von der etablierten visuellen Repräsentation sprachli­cher Laute abweicht. Um diesen Zusammenhang genauer zu erkunden, wurde ein Bildkorpus mit 27 Beispielen aus dem öffentlichen Raum erstellt und im Hinblick auf semiotische und soziolinguistische Variation analysiert. Es konnte eine große Band­breite an semiotischen Realisierungen nachgewiesen werden, die von komplexen For­men mit hoher Transkriptionstiefe bis hin zu minimalistischen Varianten reicht. Aus­gehend von dieser Analyse werden verschiedene soziostilistische Faktoren heraus­gearbeitet, die für die Variation eine Rolle spielen (Professionalisierungsgrad, Planungs­aufwand, Korrektheit), und es werden vier Dimensionen sozialer Bedeutung unterschie­den (Selbstreflexivität, definitorische Sprechakte, inszenierte Mündlichkeit, Erzeugung von Fallhöhe), die mit folklinguistischen Transkriptionen aktiviert werden können.
QR-Codes als intermediale Verknüpfungsmittel der öffentlichen Textwelt
Authors: Naumann Tobias
Published: September 2023

Zusammenfassung. QR-Codes sind keine völlig neue Entwicklung, doch ist ihr Ein­satz im öffentlichen Raum erst in den vergangenen Jahren in den Vordergrund getre­ten. Besonders die digitale Mediatisierung der Gesellschaft durch Smartphones und mobiles Internet hat die Nutzung dieser Technik für Medienunternehmen und private Nutzer deutlich interessanter gemacht. Noch ist jedoch unklar, welchen effektiven Nut­zen diese Technik bringt und welche Anwendungsbereiche sinnvoll und lohnenswert für potentielle Rezipienten sind. In diesem Beitrag möchte ich sowohl auf die technische Seite von Barcode-Strukturen eingehen als auch die Gestalt des QR-Codes unter semi­otisch-semantischen Gesichtspunkten erfassen und ihre Besonderheiten herausstel­len. Es wird untersucht, welches Wissen erforderlich ist, um QR-Codes als Zeichen zu erkennen und erfolgreich zu nutzen, und ein Beitrag zur Verdeutlichung des Nutzungs­potentials von QR-Codes als ein neuer Zeichentyp im öffentlichen Raum geleistet.
Abordaje de Cuestiones Socio-científicas en Colombia: Revisión Sistemática 2010-2020
Authors: Torres Merchán Nidia Yaneth , Pedreros Benavides Eliana Yizeth , Valderrama Daniel Alejandro
Published: September 2023

El texto caracteriza las investigaciones realizadas sobre Cuestiones socio-científicas CSC, valorando sus perspectivas y alcances, con el propósito de plantear retos en el contexto colombiano. Se efectúo una revisión bibliográfica en el periodo 2010-2020. Se analizaron 136 productos académicos, de acuerdo a los criterios de inclusión considerados en la búsqueda documental de este artículo; los productos se organizaron en cinco categorías: Uso de las CSC para promover la argumentación; desarrollo del pensamiento crítico desde el uso de las CSC; CSC y Formación de profesores, CSC e Interdisciplinariedad; CSC y apropiación de conceptos científicos. Se encontró que la categoría más trabajada corresponde a la de formación de profesores y en menor medida CSC y apropiación de conceptos científicos; también se revela que las CSC, son un campo que se ha ido fortaleciendo en el país. Dentro de los principales retos esta la necesidad de fomentar las publicaciones en el contexto internacional.
Integración de las TIC a las prácticas evaluativas de las matemáticas escolares
Authors: Jaramillo López Carlos Mario , Sánchez Sánchez Juan David , Londoño Cano René Alejandro
Published: September 2023

Este artículo pretende divulgar un análisis de revisión de literatura sobre la integración de las Tecnologías de la Información y Comunicación (TIC) a las prácticas evaluativas para el aprendizaje de las matemáticas escolares. Para tal fin, se lleva a cabo la respectiva revisión en tres fases: fase de búsqueda, fase de selección y fase de sistematización-análisis. La última etapa recibió especial énfasis, debido a que se logra desarrollar una investigación de carácter cualitativo con enfoque descriptivo. Además, en la etapa de sistematización, la información fue triangulada a través de una bitácora de búsqueda y una matriz de revisión de literatura. Estos dos instrumentos permitieron establecer 39 categorías iniciales de los textos estudiados. Luego, estas categorías pasaron por un proceso de análisis y síntesis, especificando tres categorías generales relacionadas con la pregunta. Este proceso de indagación viene esclareciendo, entre otros aspectos, que sin importar el tipo de evaluación que se articule a las TIC, los medios de recolección de información más usados son: test diagnósticos, exámenes y cuestionarios pensados para la medición y estandarización de los aprendizajes, dejando las técnicas de evaluación en las que el estudiante tiene un rol activo en lugares secundarios.
LEGAL COMPLIANCE PADA PENYELENGGARA SISTEM ELEKTRONIK FARMASI DI INDONESIA
Authors: Destyarini Normalita
Published: September 2023

Akses layanan kesehatan di Indonesia masih menjadi suatu permasalahan yang memerlukan solusi nyata sehingga dalam hal ini pemerintah merumuskan berbagai kebijakan guna terlaksananya akses kesehatan yang merata bagi penduduk. Solusi atas kemudahan akses layanan kesehatan dengan hadirnya telemedicine yang di dalamnya terdapat layanan penyelenggara sistem elektronik farmasi. Pedoman pelaksanaan legal compliance keberadaan penyedia layanan elektronik farmasi yang telah terdaftar di Indonesia dan penerapan tanggung jawab hukum penyedia layanan elektronik farmasi. Pendekatan penelitian menggunakan yuridis normatif, dengan pendekatan perundang-undangan (statute approach). Keberadaan penyelenggara layanan elektronik farmasi telah melaksanakan legal compliance hingga memperoleh izin dari Kementerian Kesehatan dan tanggung jawab hukum yang diberikan oleh penyedia layanan tertuang dalam syarat ketentuan pada laman situs.
AIRCRAFT FINANCING INDUSTRY: JURIDICAL ANALYSIS OF GUARANTEE AGREEMENT IN THE AIRCRAFT FINANCING INDUSTRY
Authors: Kuning Fazahra Rimbani , Prabandari Adya Paramita , Putrijanti Aju
Published: September 2023

All humans require various supports to progress in life, particularly in Indonesia. People's mobility is required at a rapid pace due to the shape of Indonesia as an archipelago. The aviation industry is one of the supporting factors. Indonesians require the use of both domestic and international aircraft. As a result, massive procurement of aircraft fleets takes place. The airline requires financing to support the aviation sector as a capital-intensive and high-technology industry in its procurement. Every business activity must require collateral to prevent the parties from defaulting. As a result, the contents of this journal will explain the entire discussion of financing and collateral in accordance with applicable laws.
Forensic Accounting Techniques and Corruption in the Public Sector of South-West, Nigeria
Authors: Alao O , Adegbie F. F. , Ogundajo G. O.
Published: September 2023

Corruption is recognized as a significant global challenge which remains unresolved, Nigeria inclusive. It continues to impede progress, economic growth, and social development. Also, Corruption have been the focus of ongoing literature discussion especially Sub-Saharan Africa, centering on the adverse effects of corruption, hindering post-pandemic recovery and efforts to address economic, ecological, and healthcare challenges. From literature, researchers focused on conventional audit as solution variable. This study, thereby, examined the effect of forensic accounting techniques on corruption in the public sector of South-West, Nigeria. The study adopted a survey research design. The population of the study comprised 395 staff working in the Anti-graft agencies and ministry and departmental agencies in South-West, Nigeria. A sample of 254 respondents was determined using the Krejcie and Morgan formula. The result of Cronbach's alpha was greater than 0.70 and the AVE was greater than 0.5, the adapted questionnaire was deemed reliable and valid to proceed for analysis. The paper used the two methods of statistics (descriptive statistics and inferential statistics) to analyse the data. Forensic accounting techniques had significant effect on corruption ( Adj R2 = 0.07, F (5, 220) = 4.77, p < 0.05). Audit quality and quality of governance significantly controlled the effect of forensic accounting techniques on corruption (Adj R2 = 0.07, F (7, 218) = 3.42; p < 0.05). The study concluded that forensic accounting techniques affected corruption in the public sector of South-West, Nigeria. It was recommended that the anti-graft agencies and Ministry and departmental agencies should integrate forensic accounting techniques into their processes in order to achieve transparency and accountability in the management of public funds.  The governments of South-West, Nigeria must ensure to establish forensic accounting unit where trained expert are employed with attractive remuneration to carry out investigation cases of corruption to ensure enough evidence and facts are presented in courts for effective prosecution of such cases.
A Comparative Analysis of the Contents of “Acid-Base Neutralization Titration” in the New and Old Editions of the Textbook Published by People’s Education Press Based on Core Competencies in China
Authors: Ma Xiaoli , Hu Weiping
Published: September 2023

In the new edition of the high school chemistry textbook, published by People’s Education Press in China in 2019, the knowledge of “Acid-Base Neutralization Titration” is extracted as an independent class hour from the content of “The Application of pH” in the old edition textbook published in 2004. Based on the idea of Chinese core competencies in chemistry, the contents of “Acid-Base Neutralization Titration” in the 2019 edition and the 2004 edition of Chinese high school chemistry textbooks are compared and analyzed in this paper. It is found that the new edition of textbook is optimized in many aspects, for example, a variety of columns are set up, exercises are simplified, and the content is more concise and organized. At the same time, some suggestions are presented about the approaches to cultivating students’ core competencies and the improvement of calculation method of the examples in the new edition of textbooks.
Development of Polish-Portuguese bilingualism in Brazil
Authors: Kukawska Agata Edyta
Published: September 2023

The aim of the article is to show the Polish-Brazilian evolution of bilingualism throughout ages. his paper shows different definitions and types of bilingualism, taking into consideration a comparison between the Polish and Portuguese language. Furthermore, I present    a review of 150 years of Polish citizens’ history in Brazil. It presents their difficulties and the approach of the Brazilian government from the 19th to the 20th century. The most significant  subject are Polish schools and organizations. Their history shows how the command of Polish and Portuguese changed throughout ages. There were different conditions, affecting the command of languages in the Polish Diaspora, such as the familial approach or access to Polish culture. I also mention which organizations and people had the biggest impact on Polish citizens in Brazil. I also describe the existing attitude to both cultures and languages in Polish communities. Apart from that, I try to understand the identity and acquaintance of Polish culture nowadays and show actions as a resultof which Polish language and history are promoted nowadays.
Regularity of optimal mapping between hypercubes
Authors: Chen Shibing , Liu Jiakun , Wang Xu-Jia
Published: September 2023

In this note, we establish the global

C

3
,
α

{C}^{3,\alpha }

regularity for potential functions in optimal transportation between hypercubes in

R

n

{{\mathbb{R}}}^{n}

for

n
≥
3

n\ge 3

. When

n
=
2

n=2

, the result was proved by Jhaveri. The

C

3
,
α

{C}^{3,\alpha }

regularity is also optimal due to a counterexample in the study by Jhaveri.
发展与挑战: 从一个大学的中文项目看美国中文教育的发展
Authors: 温 晓虹
Published: September 2023

提 要

本文以美国某一大学中文项目的发展为例, 从三个方面探讨了近三十年来北美中文教学的状况: (1) 机遇中的发展, (2) 面临的挑战, (3) 应对策略。这三十年我们经历了之前生源的空前高涨, 以及近期由于国际形势变化特别是全球疫情的出现影响到中文课注册人数、尤其是中文主修人数的锐减。面对机遇和挑战, 本文在给休斯顿大学的中文研究项目定向定位的同时, 结合近年来对北美中文教育发展的调查、对学习动机学习目的的系列研究, 总结了应对策略。建立在研究结果和学生反思与评价的基础上, 本文针对课程设计、教学要求, 以及如何服务多元背景不同学习动机的学生等方面, 提出建立高质量严要求的中文项目。教师需要营造一个从自己学生的需求特点出发、教学互动性强的课堂氛围, 以帮助学生获得所学内容的实用感与正面的学习体验。这是学生继续修中文课的前提。
汉语为二语项目建设的理论与实践: 从教学法、师资培训谈起
Authors: 靳 洪刚
Published: September 2023

提要

二十一世纪新时期给我们带来了新的教学常态和新的挑战, 汉语为二语教学领域也开始对项目建设提出了一系列新的思考。本文的讨论主要集中在教学法和师资培训这两个方面的挑战和机遇。在教学方法上, 本文提出新时期的教学要采用一套有新理论、有程序、有相应技巧的教学法系统。这一系统基于成人学习二语的特点, 不但把教学重点放在课堂的教学过程上, 而且提供系统的基础理论、具体的教学程序和实施技巧, 便于教师掌握、操作。在师资培训上, 本文提出一种混合模式的教师培训 (a hybrid teacher training model), 兼顾理论和实践, 结合模拟与真实课堂的教学, 进行分课型、分技巧、结合科技的训练, 利用线上、线下反复练习等, 以保证教师的专业能力发展。
Platelet distribution width (PDW) as a significant correlate of COVID-19 infection severity and mortality
Authors: Ligi Daniela , Della Franca Chiara , Notarte Kin Israel , Goldrich Nathaniel , Kavteladze David , Henry Brandon Michael , Mannello Ferdinando
Published: September 2023

SARS-CoV-2 infection may cause a wide spectrum of symptoms, from asymptomatic, to mild respiratory symptoms and life-threatening sepsis. Among the clinical laboratory biomarkers analyzed during COVID-19 pandemic, platelet indices have raised great interest, due to the critical involvement of platelets in COVID-19-related thromboinflammation. Through an electronic literature search on MEDLINE, CINAHL, PubMed, EMBASE, Web of Science, and preprint servers we performed and updated a systematic review aimed at providing a detailed analysis of studies addressing the potential clinical utility of platelet distribution width, platelet distribution width (PDW), in laboratory medicine, exploring the possible association between increased PDW levels, disease severity, and mortality in COVID-19. Our systematic review revealed a wide heterogeneity of COVID-19 cohorts examined and a lack of homogenous expression of platelet indices. We found that 75 % of studies reported significantly elevated PDW values in COVID-19 infected cohorts compared to healthy/non-COVID-19 controls, and 40 % of studies reported that patients with severe COVID-19 showed increased PDW values than those with less-than-severe illness. Interestingly, 71.4 % of studies demonstrated significant increased PDW values in non survivors vs. survivors. Overall, these results suggest that platelets are critically involved as major players in the process of immunothrombosis in COVID-19, and platelet reactivity and morphofunctional alterations are mirrored by PDW, as indicator of platelet heterogeneity. Our results confirm that the use of PDW as prognostic biomarkers of COVID-19 sepsis still remains debated due to the limited number of studies to draw a conclusion, but new opportunities to investigate the crucial role of platelets in thrombo-inflammation are warranted.
Utilization of nanoparticles and waste materials in cement mortars
Authors: Owaid Haider M. , Humad Abeer M. , Al-Gburi Majid , Ghali Zainab Abdul Sattar , Sas Gabrial
Published: September 2023

Cement has shaped the modern built environment, but its production generates substantial carbon dioxide emissions. Consequently, there is an urgent need to identify alternative cementitious building materials for sustainable construction. In this study, cement mortars (CMs) were produced by partially replacing cement with nanoclay (NC) and granite dust (GD). The replacement proportions (% by weight of cement) of these materials were 1.5, 3, and 4.5% for NC and 10, 20, and 30% for GD. For mortars containing NC but not GD, the strength was maximized when the NC replacement proportion was 3%. To evaluate the combined effect of partially replacing cement with both NC and GD on the fresh and hardening properties of cement-blended mortars, ternary binder mixtures containing 3% NC together with 10, 20, or 30% GD were prepared, and their workability, bulk density, compressive strength (at 7, 28, and 90 days), and flexural strength were measured. Increasing the content of NC and/or GD reduced the flowability of these mortars relative to that of the reference mortar mix because it increased the content of fine materials. CM containing 3% NC and 10% GD had the highest compressive strength at 7, 28, and 90 days while also having the greatest flexural strength when compared to the control mix. This is most likely due to the high silica and alumina content of NC and GD, as well as their high specific surface area, which would improve the maturity and density of the matrix when compared to cement alone.
The sternal brace: a novel osteopathic diagnostic screening tool to rule out cardiac chest pain in the emergency department
Authors: Gianneschi Garrett , Patel Sarthak , Hinfey Patrick
Published: September 2023

Context

Chest pain is one of the most common emergency medicine complaints in the United States, yet no reliable physical examination finding exists to help differentiate cardiac chest pain (CCP) from noncardiac chest pain (non-CCP).

Objectives

This is a diagnostic accuracy study of the sternal brace, a novel physical examination maneuver to rule out cardiac-related chest pain from non-CCP.

Methods

We performed this double-blind prospective diagnostic accuracy pilot study on 34 adults in the Newark Beth Israel emergency department with a chief complaint of chest pain. We utilized the Numerical Rating Scale 0–10 (NRS) to quantify chest pain severity before and after the maneuver. Eligible for inclusion were adults over 18 years old who were able to provide written informed consent. We performed the sternal brace on all consenting adults meeting these criteria, and the researchers were blinded between test results and final diagnosis. Cardiac ischemia in the US with a disease prevalence of 0.029 was utilized.

Results

A total of 34 patients were included, of whom 11 had a final diagnosis of cardiac-related chest pain. The cutoff value was a decrease in pain severity of 2 or greater between pretest and posttest. Sensitivity was 81.8 % (95 % confidence interval [CI], 48.2–97.7 %); specificity 34.8 % (95 % CI, 16.4–57.3 %), the positive predictive value was 3.6 % (95 % CI, 0.1–20.3 %), and the negative predictive value was 98.4 % (95 % CI, 66.8–100.0 %).

Conclusions

The sternal brace is a good screening test because if a person with chest pain has an NRS that decreases by 2 or more with the maneuver, then there is a 98.5 % chance that the chest pain is noncardiac, given the prevalence of cardia ischemia. In addition, if the disease is present, then it is 81.8 % likely that their NRS will not decrease by more than 2.
Roundtable Discussion of Emerging Technology Companies and Transcultural Challenges
Authors: Zhang Zhan , Balbi Gabriele , Thussu Daya , Winseck Dwayne , Jiang Fei
Published: September 2023

The conference and special issue of The Trajectory of Emerging Media
and
Technology
Companies at the Journal of Transcultural Communication explore how transnational media and technology corporations transform global communication. We leveraged various analytical tools to examine the companies’ structure, the country-specific advantages, regulation methods and development dynamics, media system models, and the transcultural implication for business expansion and product/content/service distribution. We also invited three eminent communication scholars to share their perspectives on the global trajectory and paradox of technology companies.
Intelligent nanomaterials for cancer therapy: recent progresses and future possibilities
Authors: Wang Jing , Zhao Yuliang , Nie Guangjun
Published: September 2023

Intelligent nanomedicine is currently one of the most active frontiers in cancer therapy development. Empowered by the recent progresses of nanobiotechnology, a new generation of multifunctional nanotherapeutics and imaging platforms has remarkably improved our capability to cope with the highly heterogeneous and complicated nature of cancer. With rationally designed multifunctionality and programmable assembly of functional subunits, the in vivo behaviors of intelligent nanosystems have become increasingly tunable, making them more efficient in performing sophisticated actions in physiological and pathological microenvironments. In recent years, intelligent nanomaterial-based theranostic platforms have showed great potential in tumor-targeted delivery, biological barrier circumvention, multi-responsive tumor sensing and drug release, as well as convergence with precise medication approaches such as personalized tumor vaccines. On the other hand, the increasing system complexity of anti-cancer nanomedicines also pose significant challenges in characterization, monitoring and clinical use, requesting a more comprehensive and dynamic understanding of nano-bio interactions. This review aims to briefly summarize the recent progresses achieved by intelligent nanomaterials in tumor-targeted drug delivery, tumor immunotherapy and temporospatially specific tumor imaging, as well as important advances of our knowledge on their interaction with biological systems. In the perspective of clinical translation, we have further discussed the major possibilities provided by disease-oriented development of anti-cancer nanomaterials, highlighting the critical importance clinically-oriented system design.
High-fidelity optical fiber microphone based on graphene oxide and Au nanocoating
Authors: Hou Liangtao , Li Yan , Sun Libin , Liu Chao , Zheng Yichao , Liu Yi , Qu Shiliang
Published: September 2023

A high-fidelity optical fiber microphone (HF-OFM) with hybrid frequency and fast response is theoretically and experimentally demonstrated by the nanofabrication techniques for real-time communication, which consists of a graphene oxide (GO) film, an Au nanocoating, and an air cavity. The internal stress of the film is increased by the method of mechanical tensile preparation, and the microphone response flatness is improved. Meanwhile, the structural design of the 3 nm Au nanocoating improves the acoustic pressure detection sensitivity by 2.5 times by increasing the reflectivity. The experimental result shows that single, dual, and triple frequency acoustic signal detection in the frequency range of 0.1 kHz–20 kHz are achieved with acoustic pressure sensitivities of 9.64, 9.66, and 8.9 V/Pa, as well as flat frequency response (<2 dB variation). The minimum detectable pressure (MDP) at 1 kHz is 63.25 μPa/Hz1/2. In addition, the high-fidelity real-time transmission of audio signals over an angle range of −90° to 90° is verified by a self-made acoustic pressure detection device. Such a compact, high sensitivity, and large measurement range HF-OFM is very promising for applications of oil leakage exploration, acoustic source location, and real-time communication.
An exploratory study of a simplified approach to evaluate drug solubility in milk related vehicles
Authors: Li Sean , Gabriel Justin , Martinez Marilyn , Longstaff David , Coffey Martin , Zhao Fang
Published: September 2023

Objectives

Milk related materials are frequently used as a vehicle for drug product administration. Therefore, drug solubility information in milk related vehicles is desirable for prediction of how they may influence in vivo drug release and bioavailability. However, there are very limited data published on this topic. This study explored a practical method to address the key challenges associated with solubility assessment in milk, including the sample equilibration time and cleanup procedures.

Methods

Amitriptyline, acetaminophen, dexamethasone, nifedipine, piroxicam, and prednisolone were selected as model drugs to represent a wide range of physicochemical properties. Their solubilities were determined at room temperature in pH 6.8 phosphate buffer, skim milk, whole milk, reconstituted milk powder, and unprocessed raw milk.

Results

The overall results confirmed that milk greatly improves the solubility of poorly water-soluble drugs. However, the extent of improvement and mechanism of solubilization appeared unique for each drug, highlighting the importance of evaluating milk solubility experimentally.

Conclusions

The method used in this exploratory study can be applied in future investigations of a broader range of drugs and milk-related vehicles.
Projetos unificados do Centro de Artes da UFPel | 2020
Authors: Fernandes Cátia , Santos Josiane , Martins Larissa
Published: September 2023

Divulgar, através desta publicação, os projetos unificados do Centro de Artes ocorridos no ano de 2020 – atividade complexa porque exige a colaboração de vários profissionais – é um modo acessível de tornar visível as realizações do Centro de Artes da Universidade Federal de Pelotas. Considerada a unidade com o maior número de projetos cadastrados, o Centro de Artes – mesmo em um ano tão atípico – manteve vivas suas ações mostrando todo o potencial de ensino, pesquisa e extensão da UFPel. Cabe ressaltar que neste material gráfico presentamos uma unidade plural que abriga cursos de diferentes linguagens artísticas e saberes que se entrecruzam, favorecendo encontros, convergências de interesses, construção de vínculos, sentidos de pertencimentos e formas de socialização. Ao longo do ano de 2020, face às restrições impostas pela covid-19, muitas das ações tiveram que ser repensadas. Todavia observamos que, apesar de grande parte dos projetos terem se dado de forma remota, não perdemos o vigor e rigor historicamente oferecidos, e constatamos que, ao mesmo tempo, a modalidade on-line possibilita levá-los cada vez mais longe, aproximando diferentes comunidades interessadas. As organizadoras da presente publicação agradecem aos coordenadores (as), estudantes, técnicos(as), docentes, bolsistas e colaboradores(as) por fazerem de 2020 um ano no qual todos tivemos que nos reinventar, aprendendo novas ferramentas e estratégias, transformando a adversidade em mais aprendizagem. O contexto pandêmico que nos isolou em nossas casas, também nos impulsionou a criarmos diferentes alternativas de trabalhar coletivamente e de buscarmos outros canais de diálogo. Assim, as ações dos diferentes projetos foram transformadas criativamente, mediante exercício de propor soluções, de reunir e de alcançar pessoas (mesmo que virtualmente), em pensar e debater, em (re) existir enquanto unidade que opera sobre e a partir das realidades.
Rotina de pernas pro ar
Authors: Martins Malüe Eduarda , Mielke Varzim Marta , Gomes Cardozo Tiffani , Neuenfeld Munhoz Tiago , Luz Levandowski Mateus
Published: September 2023

Este livro é resultado do projeto de ensino “Estresse e Saúde” ocorrido no segundo semestre de 2020 vinculado ao Núcleo de Saúde Mental, Cognição e Comportamento (NEPSI) do curso de Psicologia da Universidade Federal de Pelotas (UFPel). O projeto foi coordenado pelos professores Mateus Luz Le- vandowski e Tiago Neuenfeld Munhoz, ambos vin- culados ao curso de Psicologia. Este trabalho foi elaborado pelas graduandas Eduarda Malüe, Marta Mielke Varzim e Tiffani Cardozo. O trabalho foi organizado como uma série de três livros (Série Coronavírus). Cada livro da série tem como objetivo apresentar, de forma lúdica e em linguagem acessível, conhecimentos teóricos e científicos do campo da saúde mental voltados à identificação e manejo do estresse em situações cotidianas. O foco do trabalho foi o período da pandemia, no entanto, suas contribuições poderão auxiliar crianças e famílias em diferentes momen- tos. Este livro traz informações sobre a mudança de rotina na vida da criança e sua família durante o período pandêmico. Além disso, também serão abordados os problemas relativos à desorganização da rotina e à adaptação das famílias às mudanças advindas da pandemia.
Condensate functionalization with microtubule motors directs their nucleation in space and allows manipulating RNA localization
Authors: Cochard Audrey , Safieddine Adham , Combe Pauline , Benassy Marie‐Noëlle , Weil Dominique , Gueroui Zoher
Published: September 2023

The localization of RNAs in cells is critical for many cellular processes. Whereas motor‐driven transport of ribonucleoprotein (RNP) condensates plays a prominent role in RNA localization in cells, their study remains limited by the scarcity of available tools allowing to manipulate condensates in a spatial manner. To fill this gap, we reconstitute in cellula a minimal RNP transport system based on bioengineered condensates, which were functionalized with kinesins and dynein‐like motors, allowing for their positioning at either the cell periphery or centrosomes. This targeting mostly occurs through the active transport of the condensate scaffolds, which leads to localized nucleation of phase‐separated condensates. Then, programming the condensates to recruit specific mRNAs is able to shift the localization of these mRNAs toward the cell periphery or the centrosomes. Our method opens novel perspectives for examining the role of RNA localization as a driver of cellular functions.
Estudio Longitudinal del Impacto de las Tertulias Dialógicas y Grupos Interactivos en el Desarrollo de la Motivación Lectora
Authors: Galindo-Domínguez Héctor , Sainz de la Maza Martín , Losada Iglesias Daniel
Published: September 2023

El objetivo del presente estudio ha sido el de conocer si las principales Actuaciones Educativas de Éxito, tales como los grupos interactivos y las tertulias dialógicas, contribuyen a mejorar la motivación lectora del alumnado más desfavorecido de Educación Primaria y Educación Secundaria. Para tal fin, se llevó a cabo un estudio pre/post en una Comunidad de Aprendizaje con la participación de 186 estudiantes de Educación Primaria y Secundaria, los cuales cumplimentaron la Escala de Motivación Lectora. Los resultados revelaron lo siguiente: (1) el Valor por la lectura del alumnado de Educación Secundaria fue inferior al del alumnado de Educación Primaria tanto en la fase pre como en la fase post; (2) en Educación Primaria, el alumnado con bajo rendimiento académico mejoró su Valor por la Lectura más que el alumnado con medio y alto rendimiento, y el alumnado repetidor mejoró su Autoconcepto Lector con el paso del tiempo más que el alumnado no repetidor; (3) en Educación Secundaria, el alumnado, independientemente de su rendimiento, mejoró su Autoconcepto Lector con el paso del tiempo. Estos datos apoyan la idea de que las Actuaciones Educativas de Éxito podrían ser intervenciones interesantes para mejorar la Motivación Lectora, especialmente con el alumnado más desfavorecido en Educación Primaria, reduciendo así la desigualdad de oportunidades.
Simulaciones de Liderazgo Escolar: Una Visión Panorámica de sus Publicaciones y Evolución
Authors: Jeldres Rolando , Volante Paulo
Published: September 2023

Las simulaciones para el aprendizaje profesional son herramientas que permiten la ejercitación práctica de habilidades de liderazgo, y una respuesta concreta a la necesidad de avanzar a una formación menos teórica y abstracta. La presente revisión bibliográfica ofrece un panorama sobre las publicaciones que abordan el uso de estas herramientas desde mediados de los años 90. Se revisaron las bases de datos Web of Science, Scopus, y Google Scholar, identificando 48 artículos que presentan usos y aplicaciones de simulaciones de liderazgo escolar. Las categorías de análisis destacan los tipos de publicaciones, características de las simulaciones que utilizan, así como los propósitos de estas. Se detectaron publicaciones “teórico-conceptuales”, “reportes de desarrollo”, y “evaluaciones de efectos” en las aplicaciones de simulaciones. Los tipos de simulaciones se clasificaron como “juego de roles”, “basadas en computadores”, y “escenarios híbridos”. Respecto los propósitos formativos, se observan énfasis en: “manejo de conflictos”, “percepción de autoeficacia”, “decisiones administrativas”, “gestión del cambio”, y “manejo comunicacional”. Se concluye que estas herramientas tienen un fuerte potencial para el aprendizaje de la toma de decisiones en roles de liderazgo en contextos escolares, y para proveer experiencias que anticipan desafíos profesionales propios de la cultura escolar.
El DUA para Superar Barreras: La Voz del Alumnado Universitario con TEA
Authors: Barrera Mercé , Moliner Odet
Published: September 2023

Durante los últimos años estamos avanzando hacia la construcción de contextos educativos más inclusivos preocupados por favorecer la participación y el aprendizaje de todo el alumnado, así como por ofrecer la igualdad de oportunidades. Sin embargo, en el ámbito universitario es todavía una cuestión que está emergiendo, pues el alumnado con diversidad funcional sigue encontrándose barreras que dificultan su paso por la universidad. Desde este marco, en el presente estudio nos propusimos analizar qué facilitadores y barreras hacia la participación y el aprendizaje detecta el alumnado universitario con el Trastorno del Espectro Autista en las prácticas docentes desde el paradigma del Diseño Universal para el Aprendizaje. Para ello, desde un enfoque cualitativo, utilizamos la técnica de la entrevista semiestructurada con 7 estudiantes con autismo de la Universitat Jaume I. Los resultados evidencian que este alumnado todavía se encuentra con diversos obstáculos para su participación y aprendizaje. La escasa visibilización de objetivos, la ausencia de guías para la planificación o la limitada incorporación de sus intereses en los contenidos son algunos de ellos. Como conclusión, se proporcionan diversas recomendaciones dirigidas al profesorado con el fin de superar las barreras detectadas y atender a las necesidades del alumnado desde el diseño universal.
Synergistic Effect of Ramie and Pineapple Fibres Reinforcement on The Strength of Epoxy Matrix Composite
Authors: Mercy J. Lilly , Anand D Alex , Samrot Antony V , Rajalakshmi D. , Shobana N. , Dhiva S. , Kasirajan Kasipandian
Published: September 2023

Natural fibre reinforced composite of pineapple and ramie fibre unidirectional mats were fabricated through handlayup process and curing through compression molding process. Six samples of the composite material with different combinations of alternating fibres and orientations of the fibre mats were fabricated and tested for their mechanical properties. It was observed that the stacking sequence, type of fibre and orientation of the fibres make a pronounced difference in the mechanical properties. The outer layer of Ramie fibre mat and the 45° orientation of either of the fibres resulted in better mechanical properties. By making a perfect combination of the stacking sequence of the fibres, type of fibres and orientation, it is possible to enhance the properties of the composite.
Projected Cash Flow Model by Activities for Decision Making in Private Companies in Peru
Authors: Caballero-Montañez R.W. , Huanca-Callasaca H.R. , León-Zarate A.M. , Polo-Luz R. , Zapata-Urdiales J.J. , Ordoñez-Ferro A.C.
Published: September 2023

The objective of the research was to develop a projected cash flow model by activity, a situation that is not shown in traditional cash flows. The article uses a deterministic cash flow model based on the liquidity position at the date on which the financial statement is formulated, according to which the total cash flow, that is, the net change in cash, will be realized according to the balance of the Statement of Cash Flows, Operating Flows and the Investment Flows that may be present, although they are infrequent and at the same time are normal activities of a company. It also shows a contribution to the theories and practices is the expansion of knowledge in financial theory on cash resources, which were confirmed by the research and conclusions regarding the analysis of open capital companies in the emerging market. It was concluded that the analyzed model can form the basis for improving decision making and finance management in companies.
Synthesis, Molecular Docking Studies and Cytotoxic Screening of Novel 2-Substituted Benzimidazole Derivatives
Authors: Kankate Rani S. , Surse Sunita , Abhang Pooja , Kakad Smita , Kshirsagar Sanjay
Published: September 2023

Cancer is one of the most serious lifethreatening diseases for which there is presently no cure. According to current World Health Organization (WHO) reports cancer is responsible for one out of every six deaths worldwide. Benzimidazole is a heterocyclic, aromatic molecule that acts as a biological scaffold with anticancer, antitumor, and antiproliferative activities, among other biological effects. benzimidazole and oxazole are the important pharmacophore in the medicinal chemistry, due to their widespread pharmacological activities. So, to exploit their anticancer potential we have selected these two for our research work. So, in order to develop potential anticancer agents, it was considered of interest to synthesize some benzimidazole derivatives. Before synthesis of molecule, Molecular docking was done and afterwards the compound with lowest dock score selected for synthesis. Synthesized derivatives Characterized By Proton Nuclear Magnetic Resonance (1H NMR), Infra-Red (IR), And Mass Spectroscopy (MS) and screen for cytotoxic activity.
An Evaluation of The Theory of Abuse of Rights: Between Sharia and Civil Law a Comparative and Analytical Study
Authors: Rashed Tarek , Saad Mahmoud , Yahia Khawlah A.
Published: September 2023

Purpose: This research aims to show how Egyptian and Qatari legislators codify the “abuse of rights” theory and compare it with Islamic law. This is done to correct the defects and deficiencies in the Egyptian and Qatari legal texts. Although the Arab laws are considered among the first laws that adopted this theory, they did not establish private regulation for this theory in their legal rules. Instead, they copied French civil law, which created a conflict between Islamic jurisprudential rules and the legal texts. Methodology: This Article has been written using two methodologies to find answers to the fundamental questions raised by this Article. The first methodology analyzes the legal texts that regulate the theory of Abuse of Rights in Egyptian and Qatari laws. In contrast, the second one is based on comparing the legal texts with Islamic jurisprudential rules. Findings: In the end, we concluded that the theory of “abuse of rights” was stipulated in the Egyptian and Qatari Civil Codes, and judicial rulings established the application of this theory. However, Article (5) of the Egyptian Civil Code and Article (63) of the Qatari Civil Code do not involve this theory. On the other hand, the general texts in Mecelle have organized this theory better and more accurately. Originality: The originality of this Article lies in the fact that it analyzed the position of the Egyptian and Qatari legal texts and commented on the judicial provisions issued by the Egyptian and Qatari courts of Cassation and the Arab courts, and the opinions of civil law jurists related to “abuse of the right.” Moreover, it criticized these texts and highlighted aspects of their deficiencies in comparison with the jurisprudential rules extracted from Islamic law.
Juvenile Idiopathic Arthritis With Associated Inflammatory Bowel Disease and CARD8 Mutation
Authors: Gennaro Victoria L. , Maclin Jeanine , Weiser Peter , Stoll Matthew L. , Smitherman Emily A.
Published: September 2023

Juvenile idiopathic arthritis is a common chronic childhood disease, with a prevalence of ∼1 per 1000 children. Arthritis can also be a manifestation of other inflammatory conditions, such as inflammatory bowel disease (IBD). Studies suggest a genetic influence in IBD, including mutations in CARD8. CARD8 is a negative regulator of the NLRP3 inflammasome, and mutations in this gene are hypothesized to induce gastrointestinal inflammation. However, few studies have evaluated this association and most have included a limited number of patients. We present a case of a pediatric patient with IBD-associated arthritis and a CARD8 mutation. Our patient is a 7-year-old female who was initially evaluated by rheumatology for right leg pain and an intermittent rash. She had clinically active arthritis on exam and was started on methotrexate with only slight improvement. Additional workup revealed sacroiliitis by imaging, elevated inflammatory markers, no anemia, and a variant of unknown significance in CARD8. Adalimumab was recommended but before medication initiation, our patient’s symptoms progressed to worsening joint pain, fatigue, fevers, nausea, vomiting, diarrhea, and hematochezia. Infectious testing was negative. Fecal calprotectin was >8000 µg/g. A colonoscopy revealed IBD most consistent with Crohn’s disease. Adalimumab was ultimately added, and she has responded well to combination therapy. This case report highlights the association between CARD8 mutations and IBD, especially in the setting of IBD-associated arthritis.
Goethe als Sprachhistoriker
Authors: Wolf Norbert Richard
Published: September 2023

The famous verses from Goethe’s ‚Faust I‘ Mein schönes Fräulein, darf ich wagen, / Meinen Arm und Geleit Ihr anzutragen? and Margarethe’s answer Bin weder Fräulein, weder schön, / Kann ungeleitet nach Hause gehn. repeatedly provoke discussion about why Margarethe emphasizes that she is not a Fräulein. It is also clear from other passages in the text, especially in the use of personal names, that Goethe likes to cite historical usage of language. We know that Goethe read early New High German texts, so we can assume that Goethe was concerned with earlier language use. Language history, especially word history, thus becomes an important tool for adequately understanding Goethe’s texts.
Stille Fragen: ein psychoanalytischer Blick auf die Identitätssuche in Ernst Weiß’ ‚Marengo‘ (1926)
Authors: Smrkovský Michal
Published: September 2023

The aim of the article is to present this short story as a turning point in Weiß’s literary work, as his departure from expressionist influences that ushers in his existential period. The theoretical basis for an analysis of the plot draws from psychoanalytical theories of object relations (e.g. works by Fairbairn, Guntrip, Seinfeld and others), especially in connection with the so-called schizoid personality. It is in the relationality of the disillusioned protagonist that the interpretive key is sought, a key to the departure from the expressionist cult of the individual, replaced in Weiß’s late work by a series of heroes searching for their identity.