bluuebunny/crossref_metadata_2025 huggingface dataset:
HIV-1 Drug Resistance Detected by Next-Generation Sequencing among ART-Naïve Individuals: A Systematic Review and Meta-Analysis
Authors: Ouyang Fei , Yuan Defu , Zhai Wenjing , Liu Shanshan , Zhou Ying , Yang Haitao
Published: February 2024

Background: There are an increasing number of articles focused on the prevalence and clinical impact of pretreatment HIV drug resistance (PDR) detected by Sanger sequencing (SGS). PDR may contribute to the increased likelihood of virologic failure and the emergence of new resistance mutations. As SGS is gradually replaced by next-generation sequencing (NGS), it is necessary to assess the levels of PDR using NGS in ART-naïve patients systematically. NGS can detect the viral variants (low-abundance drug-resistant HIV-1 variants (LA-DRVs)) of virus quasi-species at levels below 20% that SGS may fail to detect. NGS has the potential to optimize current HIV drug resistance surveillance methods and inform future research directions. As the NGS technique has high sensitivity, it is highly likely that the level of pretreatment resistance would be underestimated using conventional techniques. Methods: For the systematic review and meta-analysis, we searched for original studies published in PubMed, Web of Science, Scopus, and Embase before 30 March 2023 that focused exclusively on the application of NGS in the detection of HIV drug resistance. Pooled prevalence estimates were calculated using a random effects model using the ‘meta’ package in R (version 4.2.3). We described drug resistance detected at five thresholds (>1%, 2%, 5%, 10%, and 20% of virus quasi-species). Chi-squared tests were used to analyze differences between the overall prevalence of PDR reported by SGS and NGS. Results: A total of 39 eligible studies were selected. The studies included a total of 15,242 ART-naïve individuals living with HIV. The prevalence of PDR was inversely correlated with the mutation detection threshold. The overall prevalence of PDR was 29.74% at the 1% threshold, 22.43% at the 2% threshold, 15.47% at the 5% threshold, 12.95% at the 10% threshold, and 11.08% at the 20% threshold. The prevalence of PDR to INSTIs was 1.22% (95%CI: 0.58–2.57), which is the lowest among the values for all antiretroviral drugs. The prevalence of LA-DRVs was 9.45%. At the 2% and 20% detection threshold, the prevalence of PDR was 22.43% and 11.08%, respectively. Resistance to PIs and INSTIs increased 5.52-fold and 7.08-fold, respectively, in those with a PDR threshold of 2% compared with those with PDR at 20%. However, resistance to NRTIs and NNRTIs increased 2.50-fold and 2.37-fold, respectively. There was a significant difference between the 2% and 5% threshold for detecting HIV drug resistance. There was no statistically significant difference between the results reported by SGS and NGS when using the 20% threshold for reporting resistance mutations. Conclusion: In this study, we found that next-generation sequencing facilitates a more sensitive detection of HIV-1 drug resistance than SGS. The high prevalence of PDR emphasizes the importance of baseline resistance and assessing the threshold for optimal clinical detection using NGS.
Replication of Human Norovirus in Human Intestinal Enteroids Is Affected by Fecal Sample Processing
Authors: Narwankar Revati , Esseili Malak A.
Published: February 2024

Human intestinal enteroids (HIEs) culture is an emerging model for assessing the infectivity of human noroviruses (HuNoVs). The model is based on detecting an increase in HuNoV RNA post-infection of HIEs. HuNoV fecal samples used for HIE infection are traditionally processed by serial filtration. Recently, processing HuNoV fecal samples by serial centrifugation was shown to retain vesicles containing HuNoV. The objective of this study was to investigate whether serially centrifuged fecal samples, RNA extraction kit (QIAamp versus MagMaX) and HIE age (newer versus older) affect HuNoV RNA fold increase in HIE. HuNoV GII.1, GII.4 and GII.6 fecal samples were prepared by serial centrifugation and filtration and the viral RNA in HIE was quantified at 1 and 72 h post-infection (hpi) following RNA extraction and RT-qPCR. The serially filtered GII.1, GII.4 and GII.6 showed successful replication in HIE, resulting in mean log increases of 2.2, 2 and 1.2, respectively, at 72 vs. 1 hpi. In contrast, only serially centrifuged GII.1 showed consistently successful replication. However, using newer HIE passages and the MagMAX kit resulted in mean log fold increases for serially centrifuged GII.1, GII.4 and GII.6 (1.6, 2.3 and 1.8 log, respectively) that were similar to serially filtered samples. Therefore, HuNoV fecal sample processing and HIE age can affect virus replication in the HIE model.
Determining Hearing Thresholds in Dogs Using the Staircase Method
Authors: Guérineau Cécile , Broseghini Anna , Lõoke Miina , Dehesh Giulio , Mongillo Paolo , Marinelli Lieta
Published: February 2024

There is a growing interest in performing playback experiments to understand which acoustical cues trigger specific behavioral/emotional responses in dogs. However, very limited studies have focused their attention on more basic aspects of hearing such as sensitivity, i.e., the identification of minimal intensity thresholds across different frequencies. Most previous studies relied on electrophysiological methods for audiograms for dogs, but these methods are considered less accurate than assessments based on behavioral responses. To our knowledge, only one study has established hearing thresholds using a behavioral assessment on four dogs but using a method that did not allow potential improvement throughout the sessions. In the present study, we devised an assessment procedure based on a staircase method. Implying the adaptation of the assessed intensity on the dogs’ performance, this approach grants several assessments around the actual hearing threshold of the animal, thereby increasing the reliability of the result. We used such a method to determine hearing thresholds at three frequencies (0.5, 4.0, and 20.0 kHz). Five dogs were tested in each frequency. The hearing thresholds were found to be 19.5 ± 2.8 dB SPL at 0.5 kHz, 14.0 ± 4.5 dB SPL at 4.0 kHz, and 8.5 ± 12.8 dB SPL at 20.0 kHz. No improvement in performance was visible across the procedure. While the thresholds at 0.5 and 4.0 kHz were in line with the previous literature, the threshold at 20 kHz was remarkably lower than expected. Dogs’ ability to produce vocalization beyond 20 kHz, potentially used in short-range communication, and the selective pressure linked to intraspecific communication in social canids are discussed as potential explanations for the sensitivity to higher frequencies.
Hydrological Simulation Study in Gansu Province of China Based on Flash Flood Analysis
Authors: Zhang Bingyu , Wei Yingtang , Liu Ronghua , Tian Shunzhen , Wei Kai
Published: February 2024

The calibration and validation of hydrological model simulation performance and model applicability evaluation in Gansu Province is the foundation of the application of the flash flood early warning and forecasting platform in Gansu Province. It is difficult to perform the simulation for Gansu Province due to the fact that it covers a wide range, from north to south, with multiple climate types and diverse landforms. The China Flash Flood Hydrological Model (CNFF) was implemented in this study. A total of 11 model clusters and 289 distributed hydrological models were divided based on hydrology, climate, and land-use factors, among others. A spatiotemporally mixed runoff method and the Event-Specific Geomorphological Instantaneous Unit Hydrograph (GIUH) were applied based on large-scale fast parallel computation. To improve model calibration and validation efficiency, the RSA method (Regionalized Sensitivity Analysis) was used for CNFF model parameter sensitivity analysis, which could reduce the number of model parameters that need to be adjusted during the calibration period. Based on the model sensitivity analysis results, the CNFF was established in Gansu Province to simulate flood events in eight representative watersheds. The average NSE, REQ, and ET were 0.76 and 0.73, 9.1% and 12.6%, and 1.2 h and 1.7 h, respectively, in the calibration and validation period. In general, the CNFF model shows a good performance in multiple temporal and spatial scales, thus providing a scientific basis for flash flood early warning and analysis in Gansu Province.
Characteristics and Impact Evaluation of Hydrological and Water Quality Changes in the Northern Plain of Cixi, Eastern China, from 2010 to 2022
Authors: Zhao Yinghui , Jiang Mengyuan , Cheng Jing , Jiang Congfeng
Published: February 2024

This paper analyzes the spatiotemporal changes and patterns of a regional water environment based on the hydrological and water quality monitoring times and the geographical locations of the monitoring sections in the research area, the plain of Cixi, eastern China. Based on the calculation of runoff generation and concentration in the coastal plain river network and based on the characteristics and impact evaluation of the regional water pollution, the migration and diffusion mechanisms of surface water pollutants were studied for different sources and characteristics of pollutants entering the river in different river sections. The analytic results show that the water environment and water resource security of the coastal plain mainly cause the problem of eutrophication in the water bodies, and the input of nitrogen and phosphorus from land sources is the main cause of eutrophication in the water bodies, mainly including the production and discharge of domestic sewage, nutrient loss in aquaculture water bodies, affecting agricultural activities, etc. The evaluation also demonstrates that with the development of coastal zones and the rapid development of coastal towns, as the population in coastal plain areas continues to increase, industrial development and population growth are the main driving factors for water quality changes.
Experimental Study on the Accumulation Characteristics and Submergence Degree of Three-Dimensional Granular Rock Landslides in Shallow-Water Areas
Authors: Wang Meili , Tian Ye , Yang Shengfa , Wang Pingyi
Published: February 2024

This study combined the characteristics of rock mass structure, channel characteristics of main and tributary rivers, and flow conditions in the Three Gorges Reservoir area of the Yangtze River and designed and constructed a three-dimensional granular rock shallow-water landslide surge model test system under dynamic water flow conditions. The main influencing variables, including the volume of the landslide body, the inclination of the sliding surface, the water depth of the channel, and the flow velocity, were determined. A four-factor four-level orthogonal test design and a single-factor test design were combined to determine 28 sets of test conditions. Based on existing field surveys and physical model test simulation results, the motion process of the landslide body was divided into four stages: starting, accelerating, slowly accelerating or decelerating, and rapidly decelerating. The variations in the motion and velocity of the landslide body over time were determined by analyzing the image sequence extracted using a high-speed camera. The morphological characteristics of the landslide accumulation body were analyzed, and the submerged rate of the landslide body was statistically calculated. The relationship between the maximum bottom width of the landslide underwater accumulation body and the volume of the underwater accumulation body was established.
Siembra experimental de lechuga en sistema hidropónico
Authors: Villarreal Juan Carlos Raymundo , Medrano Gabriel Angel , Sánchez Angelita Ventura
Published: February 2024

La siguiente investigación muestra la siembra experimental de lechuga con semilla impulzion en un sistema hidropónico controlado por un time y alimentado con energía solar fotovoltaica en la zona de la Cuenca del Papaloapan en la ciudad de Tierra Blanca.
Suplementos de ômega 3 destinados à saúde neurológica disponíveis no mercado
Authors: Fidelix Marcia Samia Pinheiro , Da Silva Ana Carolina , Da Silva Vanessa Mendes
Published: February 2024

O ômega-3 propaga grande potencial na prevenção e tratamento de distúrbios psicológicos como a depressão e a ansiedade, sendo assim, evidencia-se a relevância da associação entre o consumo de ômega 3, principalmente DHA, e as doenças neurológicas e psiquiátricas. A metodologia usada neste trabalho trata-se de uma pesquisa de campo que busca avaliar o custo-benefício dos suplementos de Ômega-3 com maior teor proporcional de DHA para controle de problemas relacionados a saúde mental. Foram encontrados na pesquisa 8 amostras em 8 lojas online, em embalagens que variaram de 60 a 120 cápsulas, variando de 460mg a 1500mg na dose padrão indicada pelo fabricante, o que impactou nos valores de comercialização entre R$77,90 e R$ 199,97 (256% de variação). Após padronização de dose terapêutica (1000mg) para fins de comparação, os resultados de custo benefício dos suplementos com maior teor de DHA indicaram que o valor mínimo a ser investido pelo cliente é de R$2,33 por dose/dia. Conclui-se que, a pesquisa demostrou que atualmente não grande disponibilidade de suplementos de Ômega-3 com maior teor de DHA (n=8) no mercado online e menos ainda destinado, com clareza na rotulagem, para prescrição em situações de doenças neurológicas e psiquiátricas (n=6).
Doses terapêuticas de creatina, ômega 3, cafeína e coenzima q10 comercializadas em uma loja de suplementos da cidade de Maceió-AL
Authors: Fidelix Marcia Samia Pinheiro , De Moura Inglid Silva , De Souza Pedro Lucas Almeida
Published: February 2024

O mercado de suplementos cada vez mais vem aumentando, com intuito de garantir a segurança na determinação de doses terapêuticas, a ANVISA (Agência Nacional de Vigilância Sanitária) desenvolveu a instrução normativa em 26 de julho de 2018 contendo a lista de limites mínimos e máximos de dosagem para atingir os benefícios de um determinado suplemento. Recentemente, em 15 de outubro de 2021, a ANVISA publicou uma atualização,para diminuir os riscos à saúde da população que podem ocorrer com uso excessivo, portanto o consumidor deve buscar um profissional apto para avaliar a sua necessidade de utilização. Dessa forma nesse estudo o objetivo principal foi realizar uma análise das doses terapêuticas de 4 suplementos mais comercializados edisponíveis na loja BrasilNutry localizada em Maceió­­-AL e comparar as recomendações do fabricante com as recomendações pela ANVISA. Portanto, foi realizado um estudo de campo, no qual a coleta de dados abrangeu os quatros grupos de suplementos mais prescritos na loja, sendo eles: creatina (28 marcas), ômega 3 (19 marcas), cafeína (16 marcas) e coenzima Q10 (13 marcas), totalizando a análise de 76 suplementos alimentares. A crescente aquisição e consumo de suplementos estão cada vez mais a acessíveis ao público de em geral, não somente a atletas, esse fenômeno destaca a importância de informações precisa e embasadas para orientar os consumidores na tomada de decisões conscientes sobre a incorporação de suplementos à rotina diária, sendo o ideal avaliar a dose e o preço da dose para escolher o melhor custo beneficio.Porfim,o estudo evidenciou que os suplementos de creatina, ômega 3 e coenzima Q-10, estavam sendo comercializados de acordo com os limites mínimos e máximos das doses recomendadas pela ANVISA, influenciando positivamente nos resultados e na segurança do consumidor, sendo essencial verificar a qualidade e procedências dos suplementos, garantido a escolha de produtos confiáveis. No entanto, a maioria dos suplementos de cafeína estavam em desacordo com a legislação, o que pode gerar riscos para saúde da população que faz uso deste suplemento. Este enfoque visa fornecer informações valiosas que possam auxiliar na tomada de decisões conscientes sobre a incorporação de suplementos à rotina diária, sendo o ideal avaliar a dose e o preço da dose para escolher o melhor custo beneficio.
Avaliação da Biodisponibilidade Relativa/Bioequivalência entre formulações orais de desvenlafaxina 50 mg, em participantes brasileiros, saudáveis, em condições de jejum e pós-prandial
Authors: Loschi Juliana , Minuti Giulia , Dos Santos Andréia Araujo , Antonio Juliana Aparecida de Lima , Abuhab Abrão , Sommer Carolina , Vieira Ana Laís Nascimento , De Brito Rhubia Bethania Socorro Lemos , Antônio Márcia Aparecida , Zanin Maira Eduarda
Published: February 2024

Dois estudos, um em condição de jejum e outro na condição pós-prandial, avaliaram a bioequivalência entre dois comprimidos revestidos de liberação prolongada de desvenlafaxina 50 mg em dose única, em participantes brasileiros saudáveis de ambos os sexos. Os estudos foram conduzidos com desenho aberto, randomizado, cruzado com duas sequências, dois períodos, dois tratamentos e washout de sete dias entre os períodos. Foram realizadas coletas seriadas de sangue para quantificar a concentração plasmática de desvenlafaxina e realizar a análise farmacocinética. A bioequivalência é confirmada se os intervalos de confiança de 90% (IC de 90%) para a razão entre as médias geométricas das formulações teste e referência estiverem dentro dos limites de aceitação de 80-125% para a área sob a curva do tempo 0 à última concentração mensurável (AUC0-t) e concentração máxima (Cmáx). Para o estudo em condição de jejum foi encontrado IC de 90% para Cmáx entre 102,18% e 116,29% e ASC0-t entre 102.08% e 118.01%. Para o estudo na condição pós-prandial foi encontrado IC de 90% para Cmáx entre 107,90% e 122,25% e ASC0-t entre 105,28% e 117,10%. Com estes resultados conclui-se que as formulações apresentam equivalência terapêutica sob condições de jejum e alimentação.
O uso de antidepressivos na adolescência: uma revisão bibliográfica
Authors: Ciusz Sueli Borges , Colacite Jean
Published: February 2024

A depressão é representada por desânimos e tristeza profunda, que atinge a população em qualquer faixa etária, sendo caracterizada por transtorno psiquiátrico, quando acometidos em jovens e crianças são impactados por formas graves, realizando uma consequência negativa no comportamento social, escolar e familiar desse grupo. Objetivos: Analisar o uso de antidepressivos em pacientes adolescentes e seus efeitos colaterais. No tocante a metodologia presente pesquisa trata-se de uma revisão integrativa; as bibliotecas utilizadas para busca serão: a Biblioteca Virtual em Saúde (BVS), através da base de dados Literatura Latino-Americana e do Caribe em Ciências da Saúde (LILACS); a Scientific Eletronic Library Online (ScIELO) e o PubMed. A busca se deu utilizando-se as seguintes palavras-chave: Depressão, Uso de antidepressivos, Saúde mental, Adolescente. A busca limitou-se a estudos em seres humanos, redigidos em português, e que tenham sido publicados nos últimos 20 anos. Os resultado e Discussões apontam que a farmacoterapia é uma parte importante do tratamento da depressão na criança e no adolescente. Ela deve fazer parte de uma estratégia terapêutica mais ampla, pautada em uma exaustiva avaliação psiquiátrica da criança. Conclusão: Na literatura, ainda são poucos os estudos e investigações sobre a eficácia e segurança dos antidepressivos em crianças e adolescentes.
Argiria secundária ao uso de curativos com prata coloidal: relato de caso e revisão da literatura
Authors: Belchior Ana Clara Fernandes , Rodrigues Cesar Matheus da Silva , Da Silva Eduarda Késsia Pereira , Melo Artur Ferrer Sandres , Schwartz William Alves de Souza , Barbosa Itala Neves , de Carvalho Maíra Rocha Machado
Published: February 2024

A argiria é uma manifestação precoce da intoxicação crônica por prata. O uso da prata como curativo para feridas crônicas é frequente na assistência a saúde pelos seus raros efeitos colaterais e ação antimicrobiana, antisséptica e anti-inflamatória. Contudo, raramente o uso tópico da prata pode ocasionar intoxicação, sendo a principal delas a pigmentação azul-acinzentada cutânea, de mucosas, ungueal ou ocular. A pigmentação ungueal, principalmente restrita a lunula (azure lunulae), configura-se como uma manifestação precoce da argiria. Trata-se de uma descoloração permanente, tornando o seu diagnóstico fundamental para impedir a progressão dessa condição. OBJETIVO:  Descrever um relato de caso clínico de intoxicação por prata (argiria) em paciente em uso de curativos de prata coloidal. METODOLOGIA: Será um estudo do tipo relato de caso, trata-se, portanto, de um estudo descritivo, sem grupo controle, de caráter narrativo e reflexivo. CONCLUSÃO: O aparecimento de pigmentação específica cutânea ou ungueal, como na forma de azure lunulae deve ser monitorado em pacientes em uso de prata tópica. Além disso, devido ao potencial tóxico da prata, deve-se considerar a monitorização plasmática da prata em pacientes em tratamento tópico com produtos à base desse metal, especialmente em lesões com grande superfície de contato.
Experiência da inserção da acupuntura nos atendimentos clínicos de dor crônica
Authors: Nathasje Raphael Lacerda Barbosa
Published: February 2024

A dor crônica é um tema de enorme relevância, com estimativas indicando uma prevalência mundial de 10,1% a 55,5%. Representa um sintoma incômodo, de difícil definição e subjetivo. Considerando as possibilidades de controle, a medicação mostra-se como um dos recursos de tratamento, entretanto, em sua maioria, insuficiente para o manejo das condições dolorosas crônicas, o que requer a busca por práticas complementares. Objetiva-se relatar a experiência da realização da acupuntura de forma conjunta aos atendimentos clínicos ambulatoriais em serviço de referência em dor. As percepções e retornos da prática da acupuntura durante os atendimentos podem ser agrupados nos seguintes: sensação de relaxamento e melhor controle de dor ao final da consulta; tratamento mais célere de dores miofasciais; maior abertura para discussões sobre aspectos psicossociais da dor; maior satisfação ao final da consulta e menor resistência ao plano terapêutico proposto. A inserção de técnicas complementares como a acupuntura é uma das possibilidades de ampliação do cuidado das pessoas com dor crônica. Técnicas e reflexões clínicas que possam otimizar os atendimentos e abrir novos caminhos assistenciais são essenciais para o desenvolvimento científico do tratamento da dor.
Miomectomia videolaparoscópica nos últimos 5 anos: comparativo entre as regiões do Brasil pela perspectiva do SUS
Authors: Nonato Amanda Araújo , E Braga Anna Carla Di Nápoli Andrade , Dos Santos Neto Antônio Caetano , Pereira Clarisse Fernandes , Rodrigues Maria Cecília Ribeiro de Sá
Published: February 2024

Introdução: A miomectomia é um procedimento cirúrgico que tem como objetivo preservar úteros que apresentam leiomiomas, sobretudo em pacientes que desejam engravidar. Essa intervenção consiste na remoção dos leiomiomas, tumores benignos do miométrio, e é utilizada em pacientes com menorragia não responsiva a tratamento conservador, sensação de pressão pélvica intolerável, crescimento rápido ou mudança na consistência dos nódulos palpáveis. Tais tumores podem ser detectados em 70-80% das mulheres ao longo da vida, sendo mais comum em mulheres negras até os 50 anos. Objetivo: Analisar e comparar o número de miomectomias laparoscópicas realizadas nas regiões do Brasil entre os anos de 2019 e 2023. Métodos: Trata-se de um estudo observacional, retrospectivo, do tipo ecológico com abordagem quantitativa. Os dados foram extraídos do Departamento de Informática do Sistema Único de Saúde do Brasil (DATASUS) acerca do perfil das miomectomias videolaparoscópicas realizadas no período de janeiro/2019 a novembro/2023 em cada região. Resultados: A região Sudeste aprovou mais Autorizações de Internação Hospitalar (67,48%), atingindo o maior gasto total com miomectomias (R$283.712,80). A região Sul foi a única com redução de contas entre 2022 e 2023, enquanto a Norte apresentou incremento de 91,70%. Sobre a duração da permanência hospitalar, a média global foi 2 dias. Destaca-se o Centro-Oeste em 2020, com média de 7,3 dias. As internações por leiomioma prevalecem em mulheres de 30 a 49 anos (77,19%) e entre pardas e brancas. Conclusão: A análise do DATASUS (2019-2023) mostra maior incidência de miomectomias no Sudeste e Nordeste, com aumento de custos e variações regionais na duração hospitalar. O trabalho revela diferenças regionais e demográficas necessárias para aprimorar o tratamento e o direcionamento de políticas públicas.
Uso de complejos híbridos estabilizados de ácido hialurónico en melasma. Serie de casos
Authors: Lara del Valle Daniela Ruth , Romano Lozano Viviana
Published: February 2024

Melasma is a hypermelanosis characterized by hyperpigmented brown spots that appear in photoexposed areas. Its multifactorial etiology involves genetic and hormonal factors, exposure to ultraviolet radiation, and vascular alterations. It occurs mainly in women, and its evolution is chronic. The diagnosis is clinical, and the treatment is generally combined, as no universal treatment exists. Hybrid hyaluronic acid complexes are formed by two hyaluronic acid chains (one high-molecular weight chain and another low-molecular one). They are currently used for aesthetic purposes, but their use in clinical dermatoses has already been documented. The objective of this article is to show the results of two Mexican patients with melasma who were administered intradermal stabilized hybrid complexes of hyaluronic acid with a protocol of two applications separated by four weeks between the first and second application. With the publication of this series of cases, we contribute to demonstrating the safety and effectiveness of using stabilized hyaluronic acid hybrid complexes for dermatoses with pigmentation disorders such as melasma.
MEKANISME KOPING PADA PASIEN GAGAL GINJAL KRONIK YANG MENJALANI HEMODIALISIS DI UNIT HEMODIALISA RSUD BANDUNG
Authors: Satria Pratama Angga , Pragholapati Andria , Nurrohman Ikhwan
Published: February 2024

Gagal ginjal kronik merupakan gangguan renal yang progresif dan irreversible dimana kemampuan tubuh gagal mempertahankan metabolisme dan keseimbangan dan elektrolit, pasien gagal ginjal kronik harus menjalani terapi hemodialisis secara terus menerus seumur hidup dan akan menimbulkan masalah fisik dan psikologis yaitu depresi, pasien harus memiliki upaya dalam menyelesaikan masalah yang dihadapinnya yang dikenal dengan mekanisme koping. Tujuan penelitian untuk mengetahui mekanisme koping pada pasien gagal ginjal kronik yang menjalani terapi hemodialisis di unit hemodialisa Rumah Sakit Umum Daerah Kota Bandung.Metode penelitian menggunakan deskriptif kuantitatif. Sampel dalam penelitian ini menggunakan total sampling yaitu sebanyak 51 responden pasien gagal ginjal kronik yang menjalani terapi hemodialisis.Hasil penelitian mekanisme koping lebih dari setengahnya adalah mekanisme koping adaptif sebanyak 38 orang (74.5%). Berdasarkan hasil penelitian Perawat di ruang hemodialisa diharapkan dapat meningkatkan asuhan keperawatan secara menyeluruh yang bukan hanya biologisnya saja tapi pada psikologis pasien gagal ginjal kronik juga, seperti memberikan konseling sehingga pasien mampu menggunakan mekanisme koping yang adaptif. Kata Kunci: gagal ginjal; hemodialisis; mekanisme koping  MECHANISM OF COPING IN CHRONIC KIDNEY FAILURE IN HEMODIALYSIS PATIENTS AT REGIONAL PUBLIC HOSPITAL OF BANDUNG  ABSTRACT  Chronic renal failure is a progressive and irreversible renal disorder in which the body's ability to fail to maintain metabolism and balance and electrolytes, patients with chronic renal failure must undergo continuous hemodialysis therapy for life and it will cause physical and psychological problems namely depression, patients must have the effort to resolve the problem that is facing by knowing the coping mechanism. The purpose of this study was to determine the coping mechanism in chronic kidney failure patients undergoing hemodialysis therapy in the hemodialysis unit of Regional Public Hospital of Bandung City.The research method used quantitative descriptive. The sample in this study used a total sampling of 51 respondents from chronic kidney failure patients undergoing hemodialysis therapy.The results of research on coping mechanisms more than half are adaptive coping mechanisms as many as 38 people (74.5%). Based on the results of research Nurses in the hemodialysis room are expected to improve overall nursing care that is not only biologically but also psychologically in patients with chronic kidney failure, such as providing counseling so that patients are able to use adaptive coping mechanisms. Keywords: kidney failure; hemodialysis; coping mechanism
Cardiovascular Risk Reduction in Diabetes Mellitus, Taking into Account the Updated Recommendations of the Global Initiative to Improve the Results of Treatment of Kidney Diseases
Authors: Мохорт Т.В.
Published: February 2024

Хронические осложнения сахарного диабета, включая диабетическую болезнь почек (ДБП), определяют снижение качества и продолжительности жизни и являются предиктором смерти от кардиоваскулярной патологии. Обновленные рекомендации Глобальной инициативы по улучшению результатов лечения болезней почек определяют особенности мониторинга диабета, питания и тактики выбора антигипергликемической терапии. Современные походы основаны на выборе лекарственных средств, обеспечивающих низкий риск гипогликемических реакций, снижение кардиоваскулярных рисков и нефропротективное влияние. Также отражены инновационные походы, направленные на замедление развития почечного фиброза, основой которого является блокада альдостерона с использованием антагонистов минералокортикоидных рецепторов, включая финеренон.

Chronic complications of diabetes, including diabetic kidney disease, determine a decrease in the quality and duration of life and are a predictor of death from cardio-vascular pathology. The updated recommendations of the Global initiative to improve the results of treatment of kidney diseases determine the features of diabetes monitoring, nutrition and tactics of choosing antihyperglycemic therapy. Modern campaigns are based on the choice of medicines that provide a low risk of hypoglycemic reactions, reduction of cardio-vascular risks and nephroprotective effect. Innovative campaigns aimed at slowing the development of renal fibrosis, which is based on the blockade of aldosterone with the use of mineralocorticoid receptor antagonists, including finerenone, are also reflected.
Cardiac Involvement in High-Grade B-cell Lymphoma: A Case Report
Authors: Кондратьев Ф.В. , Зарадей И.И. , Гайшун Е.И. , Калыхан Д.М. , Булгак А.Г. , Пристром А.М.
Published: February 2024

Поражение сердца при лимфопролиферативных заболеваниях встречается, по данным аутопсий, в 8,7–20% случаев. Прижизненная диагностика данной патологии затруднена. В большинстве случаев поражение сердца носит вторичный характер, в то время как первичное составляет 0,25–2,1% всех опухолей данной локализации. Самой распространенной группой лимфопролиферативных заболеваний являются диффузные крупноклеточные B-клеточные лимфомы, а одной из редких и агрессивных групп – крупноклеточные B-клеточные лимфомы высокой степени злокачественности. C помощью трансторакальной эхокардиографии новообразования сердца диагностируются примерно в 60% случаев, при использовании чреспищеводной эхокардиографии – более чем в 90% случаев. Наиболее информативным неинвазивным методом является позитронно-эмиссионная томография / компьютерная или магнитно-резонансная томография всего тела с использованием 18F-фтордезоксиглюкозы. Верифицируется диагноз гистологическими, иммуногистохимическими, молекулярно-генотипическими методами. Поскольку опухоли сердца в клинической практике встречаются достаточно редко, каждый случай по-своему уникальный и должен тщательно изучаться.

Heart damage in lymphoproliferative diseases occurs, according to autopsies, in 8.7–20% of cases. During life, the percentage of diagnosis is significantly lower. In most cases, heart damage in is secondary, while primary heart damage occurs in 0.25–2.1% of all primary tumors of this localization. The most common group of lymphoproliferative diseases are diffuse B-cell lymphomas, and one of their rarest and most aggressive group is high-grade B-cell lymphoma. With the help of transthoracic echocardiography, neoplasms of the heart are diagnosed in about 60% of cases, with the use of transesophageal echocardiography – in more than 90% of cases. The most informative non-invasive method is positron emission tomography / computer or magnetic resonance imaging of the whole body using 18F-fluorodeoxyglucose. The diagnosis is verified by histological, immunohistochemical, molecular genotypic methods. Since heart tumors are rarely found in clinical practice, each case is unique in its own way and should be carefully studied.
“Las estacas larguruchas, que le daban a uno chucho…”. En busca de un sistema de armas elusivo: cohetes “A la congreve” en el campo de batalla de Pavón, 1861
Authors: Leoni Juan B. , Tamburini Diana S.
Published: February 2024

Los cohetes que diseñó sir William Congreve a principios del siglo XIX y que llevaron su nombre fueron utilizados en diversas campañas bélicas del siglo decimonónico en nuestro país. A pesar de ello, su visibilidad, tanto en los documentos escritos de la época como en el registro arqueológico, es muy baja. Las investigaciones arqueológicas en curso en el campo de batalla de Pavón han contribuido a cambiar esta situación, al hallarse cuatro piezas que pertenecen a cohetes “à la Congrève”. Se trata de piezas que se enroscaban en la base del cohete propiamente dicho y que servían para insertar la larga vara de madera o cola que estabilizaba al proyectil durante su vuelo. Tanto el ejército de la Confederación Argentina como el de la Provincia de Buenos Aires usaron estos cohetes en dicho enfrentamiento, del 17 de septiembre de 1861 en terrenos cercanos a la actual localidad de Rueda (Depto. Constitución, Provincia de Santa Fe). En este trabajo presentamos estos artefactos, discutiéndose sus características generales, sus condiciones de hallazgo y las implicancias interpretativas de su presencia en el campo de batalla, así como las evidencias documentales de su uso en esta campaña militar.
Studi Pengaruh Perlakuan KOH Terhadap Kekuatan Tarik Komposit Serat Rami
Authors: Lado Putra E. , Adoe Dominggus G. H. , Pah Jack C.A.
Published: February 2024

Currently, natural fiber composites have become the main choice for several industrial applications in the world. The strength of natural fibers such as hemp is based on laboratory results of mechanical strength testing which show that hemp has very suitable properties as a reinforcing composite for prosthetic socket materials. The tensile test is a mechanical stress-strain test that aims to determine the strength of a material against tensile forces. In the test, the test material is pulled until it breaks. Tensile testing is carried out to look for stress and strain (stress-strain test). From this test, we can know some of the mechanical properties of materials that are needed in engineering design. The results of research conducted on the study of the effect of KOH treatment on the tensile strength of hemp fiber composites show three things. First, the highest tensile stress value in hemp fiber was found in the 2% KOH treatment with a long soaking time of 2 hours with a value of 25.3 MPa. Second, the lowest tensile strain value in hemp fiber was found in the 6% KOH treatment with a long soaking time of 2 hours with a value of 0.1%. Third, the highest modulus of elasticity in hemp fiber was found in 6% KOH treatment with a 1-hour soaking time with a value of 47.1 MPa
Studi Kinerja Teoritis Pengkondisian Udara Menggunakan R32, R290 Dan R410a
Authors: Sengge James Roland , Dwinanto Matheus M. , Tobe Adi Y.
Published: February 2024

The use of more environmentally friendly refrigerants in air conditioning systems has become a central demand and issue in the future. This article presents the simulation results of the comparison of the use of R32 (difluoromethane), R290 (propane) and R410A (difluoromethane+pentafluoroethane) on the performance of air conditioning systems. The thermodynamic analysis of the system using the two refrigerants used the CoolTools version 1.0 software at several variations of the evaporation temperature, with the condensation temperature held constant. The important quantities analyzed are heat release in the condenser, compressor power, and coefficient of performance. The results of this study indicate that the performance of air conditioning using R290 is higher than the use of R32 and R410A while the lowest coefficient of performance is owned by air conditioning using R410A. In addition, R290 is more environmentally friendly than R32 and R410A, so the use of R290 is highly recommended
Studi Eksperimen Kinerja Penukar Kalor Kompak Sebagai Pemanas Tambahan di Rumah Pengering Hibrid
Authors: Ludji Sherly Satriani , Dwinanto Matheus M. , Koehuan Verdy A.
Published: February 2024

The process of drying a hybrid system that uses a combination of solar energy and biomass contains some useful heat in the chimney of the biomass stove. This heat waste has a high enough temperature so that with the help of a compact heat exchanger it can be used as an additional heater. The purpose of this study was to analyze the performance of a cross-flow type discrete flat plate-finned tube compact heat exchanger with an inline tube arrangement which is used as an additional heating device in the hybrid dryer housing. The test was carried out at 10.00-15.00 for three days of testing with variations in air flow velocity of 1.3 m/s, 1.6 m/s and 1.8 m/s while the velocity of water flow in the pipe was considered constant with 0.000168 m/s. s and the air flow velocity in the exhaust fan is kept constant at 1 m/s. The results of this study indicate that the overall heat transfer coefficient is strongly influenced by the effectiveness of the heat exchanger, and with the increase in the effectiveness of the heat exchanger, the heat transfer coefficient will also increase. The highest overall heat transfer coefficient was obtained on the second day, namely 99.263 W/m2.oC. The total heat transfer rate is influenced by the effectiveness of the heat exchanger but at a certain value both values ​​tend to be stable due to the limited dimensions of the heat exchanger. NTU is very influential on the effectiveness of the exchanger, and in this case the value of NTU ranges from 0.6-0.8 while the effectiveness of the heat exchanger ranges from 46%-56%
Uji kinerja Alat Uji Tarik Berbasis digital Kapasitas 500 N
Authors: Muslimin Mukhlis , Seng Ahamad , Aditiya Raden , Hartono Rudi
Published: February 2024

Tujuan penelitian untuk mengetahui unjuk kerja alat uji tarik komposit, bentuk benda uji yang akan diuji adalah komposit fragmentasi. Bahan yang digunakan sebagai bahan uji adalah komposit yang menggunakan matriks resin yukalac 157 dan sabut kelapa, sebelum membuat benda uji, metode perlakuan serat dengan asap cair terlebih dahulu dilakukan dalam 2 tahap (1) perendaman serat dengan asap cair dengan variasi 1, 2, dan 3 jam (2) kemudian serat dipanaskan dalam oven pada suhu 40 derajat selama 30 menit. Hasil penelitian menunjukkan bahwa pahat mampu menarik spesimen komposit fragmentasi telah mencapai 284 N, sedangkan perlakuan asap cair pada serat sabut kelapa berpengaruh terhadap peningkatan kekuatan komposit fragmentasi, kuat tarik maksimum terjadi pada serat perlakuan P2J sebesar 39,313 MPa. Dari hasil penelitian tersebut dapat direkomendasikan sebagai alat uji fragmentasi spesimen komposit.
Művészet és innováció az információ korában
Authors: Szécsi Gábor , Szilágyi Tamás
Published: February 2024

A művészet és innováció tárgyköre napjaink innováció-elmélettel foglalkozó szakmai műhelyeiben nagy érdeklődésnek örvendő terület – egyre növekvő szakpolitikai figyelemmel kísérve. Az új médiumok művészeti kommunikációban való megjelenése új tartalmi és formai kereteket kínál a művészet és a tömegmédia viszonyának értelmezésére, és eddig ismeretlen támpontokat kínál a művészeti innovációban érintett közösségek kooperációjának megerősödéséhez. A tanulmány e változások elemzésére vállalkozik.
Nowe stanowiska Polystichum aculeatum (Dryopteridaceae) na Podgórzu Wilamowickim i Pogórzu Śląskim (Polska południowa)
Authors: Tlałka Dariusz
Published: February 2024

In the years 2014–2023, during the research conducted in Podgórze Wilamowickie and Pogórze Śląskie, 8 sites of Polystichum aculeatum were found in unusual habitats for this species. These sites were created as a result of colonization from the mountains to the lowlands. They are extremely rare and can be destroyed accidentally.
Pierwsze stwierdzenie Phytolacca americana (Phytolaccaceae) w południowo-zachodniej Polsce
Authors: Kopij Grzegorz
Published: February 2024

A synanthropic locality of the pokeweed was found near the village Jankowice Wielkie (Olszanka commune, Brzeg district, Opole Silesia province, SW Poland) on 27.07.2022 (Figs 1, 2). Fruiting individuals were observed in a dry ditch with a row of old mulberry Morus alba on a roadsides near a poultry farm. To date, it has never been recorded in the wild in south-western Poland. Phytolacca americana can be considered as an ephemerophyte, a neophyte or as a causal alien plant in Poland.
Spiranthes spiralis (Orchidaceae) w dolinie Kalniczki (Bieszczady Zachodnie, Karpaty Wschodnie)
Authors: Zelek Robert , Krajnik Marek , Szewczyk Marian
Published: February 2024

The article presents new localities of Spiranthes spiralis (L.) Chevall. in the Eastern Carpathians. The data comes from research carried out in 2020–2023. The location of each site was defined within ATPOL grid squares (2 km × 2 km). Habitat conditions were given and the number of flowering shoots was determined. In May and September 2023, phytosociological records were made using to the Braun-Blanquet’s method.
Compras de combustible en la frontera argentina: ¿a quién financia la brecha cambiaria?
Authors:   , Dolcet Malena
Published: February 2024

Este trabajo presenta una primera aproximación de los efectos del turismo transfronterizo sobre las ventas de combustible en Argentina. Para esto, se explota la brecha entre el tipo de cambio ARS/USD oficial y su valor informal como incentivo exógeno para cruzar la frontera desde los países vecinos en búsqueda de combustible mas barato. A partir de un enfoque dinámico de diferencias-en-diferencias se explota la distancia de las estaciones de servicio a los pasos fronterizos mas cercanos, utilizando información sobre las ventas de combustible para el universo de estaciones de servicio de Argentina entre 2016 y 2022. Los principales resultados indican que la brecha del tipo de cambio podría tener efectos sobre las ventas de combustible de las estaciones localizadas cerca de la frontera. En particular, estos efectos podrían oscilar entre 25 p.p. para la nafta común y 36 p.p. para la nafta premium vis-a-vis estaciones que se encuentran lejos. Ademas, los efectos son heterogéneos dependiendo del país fronterizo (Brasil y Paraguay).
Instituciones ancla: Un referente para un futuro sostenible
Authors: Palacios Moya Lucía
Published: February 2024

La noción de institución ancla emergió en los años 2000 como un enfoque innovador para entender el papel potencial de las instituciones locales en el desarrollo de economías y comunidades locales prósperas. Este concepto tuvo su origen en Estados Unidos y ha evolucionado para convertirse en un componente fundamental político y práctico, con el fin de lograr el desarrollo urbano (Smallbone et al., 2015).
Grounding Aswaja: Efforts to Stem the Movement of Religious Radicalism in Nurul Islam Jember Boarding School
Authors: Sa'diyah Miftahus , Purnomo Maslathif Dwi
Published: February 2024

Ahlussunnah wal jama'ah itself is a teaching that adheres to the five sources of law. The five sources of law are the Qur'an, Hadith, Fiqh, Ijma', Qiyas. And Indonesia is a country with the largest Muslim population in the world, with the majority adhering to the teachings of ahlussunnah wal jama'ah (aswaja). This article reviews the efforts made by Educational Institutions to ground Aswaja's identity. In particular, the cultivation of the Aswaja identity was carried out to ward off the Transnational Islamic movement which is currently rife among teenagers, especially in educational institutions. This article examines the implementation of Aswaja learning material at Islamic Junior High School Nurul Islam. This implementation is an effort to strengthen the understanding of Wasatiyah Islam among students so that it is not easy to get caught up in radical takfiri teachings. This study uses field research (field research) with qualitative methods. The approach used in this research is a descriptive research approach. The results of the study showed that the implementation of the Aswaja material at Islamic Junior High School was carried out through three stages including planning, review, evaluation, and outreach to student guardians. In addition, the application of this Aswaja material contributes to increasing students' understanding of Wasatiyah Islam including its history, religious beliefs adopted, its amaliyah teachings, as well as other understandings that conflict with Aswaja or Wasatiyah Islam.
ANALISIS SEMIOTIK TOKOH WEI ZHONGXIAN DALAM FILM BROTHERHOOD OF BLADES
Authors: Wibiyanto Agung , Syaifullah Jahid , Sukendar Markus Utomo
Published: February 2024

Wei Zhongxian merupakan tokoh sejarah orang nomer dua setelah kaisar Tianqi secara nyata yang hidup di akhir kekaisaran Ming  berhasil difilmkan di dalam film Brotherhood of Blades sebagai tokoh antagonis, di mana tergolong sebagai tokoh yang culas, manipulatif dan juga korupsi. Oleh sebab itu di dalam artikel ini akan mengulas semiotika tokoh Wei Zhongxian dalam beberapa scene di film Brotherhood of Blades. Metode yang digunakan ialah metode kualitatif dengan analisis deskriptif dengan mengambil sumber di dalam beberapa scene tokoh Wei Zhongxian di film Brotherhood of Blades. Dalam membedah tokoh Wei Zhongxian dalam film ini terdiri dari dua aspek denotasi, di mana untuk aspek denotasi di masing masing scene yang didapatkan dapat dirumuskan bahwa Wei Zhongxian masih mempunyai pengaruh yang cukup kuat di dalam jajaran Jinyiwei/pasukan pelindung Kaisar Ming sehingga cukup sulit untuk menyingkirkan dirinya dan juga jaringannya di dalam tubuh pemerintahan. Sedangkan untuk aspek konotasinya, dapat dirumuskan bahwa walaupun Wei Zhongxian sudah tersingkir dalam tubuh pemerintahan, dia mampu memainkan perannya sebagai seorang politisi handal, di mana dapat disimbolkan dalam film ini dengan kekayaan materinya dan dadu sebagai simbolik dari permainan yang dia ciptakan.Kata Kunci: Wei Zhongxian, analisis semiotik, film Brotherhood of Blades
Peran Orang Tua Dalam Menumbuhkan Motivasi Belajar Pada Anak Usia Dini Dalam Upaya Meningkatkan Ilmu Agama di Sekolah Dasar Kota Tanjung Balai
Authors: Abdullah Haris Lubis
Published: February 2024

Artikel tentang tugas wali dalam inspirasi belajar pada siswa SD. Penelitian ini berencana untuk mengkaji peran wali dalam memperluas inspirasi siswa. Jenis pemeriksaan ini adalah eksplorasi subjektif. Ujian dipimpin di SD Negeri 135564 dan SD Negeri 136263 Singguan, dengan subyek 3 siswa dan 3 wali. Teknik pengumpulan informasi menggunakan rapat, persepsi, dan arsip. Penyelidikan informasi menggunakan pemeriksaan subjektif ekspresif. Hasil penelitian menunjukkan bahwa tugas wali dalam inspirasi belajar siswa adalah sebagai berikut. Subyek utama, wali memainkan peran tinggi dalam inspirasi belajar siswa. Mata pelajaran memiliki inspirasi belajar yang tinggi. Subjek berikutnya, wali berperan dalam mendorong pembelajaran siswa pada umumnya. Mata pelajaran memiliki inspirasi belajar yang khas. Subjek ketiga, tugas wali dalam membujuk siswa belajar sangat rendah. Subjek memiliki inspirasi belajar yang sangat rendah. Hasil ini menunjukkan bahwa wali memainkan peran penting dalam mengembangkan kapasitas anak-anak mereka. Wali adalah guru pertama dan utama dalam iklim keluarga. Oleh karena itu, upaya yang paling ekstrem diperlukan agar anak-anak diajarkan dalam semua perspektif dan meningkatkan pekerjaan wali sebagai guru dalam keluarga. Asosiasi wali di sekolah anak-anak mereka memacu mereka dengan cepat. Konsekuensi dari penjelajahan ini disinyalir akan mempengaruhi tugas wali dalam memperluas inspirasi belajar siswa.