bluuebunny/crossref_metadata_2025 huggingface dataset:
Pre-diagnosis tea and coffee consumption and survival after a diagnosis of ovarian cancer: results from the Ovarian Cancer Association Consortium
Authors: Nagle Christina M. , Ibiebele Torukiri I. , Bandera Elisa V. , Cramer Daniel , Doherty Jennifer A. , Giles Graham G. , Goodman Marc T. , Hanley Gillian E. , Harris Holly R. , Jensen Allan , Kjaer Susanne K. , Lee Alice W. , Milne Roger L. , Qin Bo , Richardson Jean , Sasamoto Naoko , Sieh Weiva , Terry Kathryn L. , Titus Linda , Trabert Britton , Wentzensen Nicolas , Wu Anna H. , Berchuck Andrew , Pike Malcolm , Pearce Celeste Leigh , Webb Penelope M.
Published: July 2024

Background

Tea and coffee are the most frequently consumed beverages in the world. Green tea in particular contains compounds with potential anti-cancer effects, but its association with survival after ovarian cancer is uncertain.

Methods

We investigated the associations between tea and coffee consumption before diagnosis and survival using data from 10 studies in the Ovarian Cancer Association Consortium. Data on tea (green, black, herbal), coffee and caffeine intake were available for up to 5724 women. We used Cox proportional hazards regression to estimate adjusted hazard ratios (aHR) and 95% confidence intervals (CI).

Results

Compared with women who did not drink any green tea, consumption of one or more cups/day was associated with better overall survival (aHR = 0.84, 95% CI 0.71–1.00, p-trend = 0.04). A similar association was seen for ovarian cancer-specific survival in five studies with this information (aHR = 0.81, 0.66–0.99, p-trend = 0.045). There was no consistent variation between subgroups defined by clinical or lifestyle characteristics and adjustment for other aspects of lifestyle did not appreciably alter the estimates. We found no evidence of an association between coffee, black or herbal tea, or caffeine intake and survival.

Conclusion

The observed association with green tea consumption before diagnosis raises the possibility that consumption after diagnosis might improve patient outcomes.
Suppression of viral rebound by a Rev-dependent lentiviral particle in SIV-infected rhesus macaques
Authors: Hetrick Brian , Siddiqui Summer , Spear Mark , Guo Jia , Liang Huizhi , Fu Yajing , Yang Zhijun , Doyle-Meyers Lara , Pahar Bapi , Veazey Ronald S. , Dufour Jason , Andalibi Ali , Ling Binhua , Wu Yuntao
Published: July 2024

Persistence of human immunodeficiency virus (HIV) reservoirs prevents viral eradication, and consequently HIV-infected patients require lifetime treatment with antiretroviral therapy (ART) [1–5]. Currently, there are no effective therapeutics to prevent HIV rebound upon ART cessation. Here we describe an HIV/SIV Rev-dependent lentiviral particle that can be administered to inhibit viral rebound [6–9]. Using simian immunodeficiency virus (SIV)-infected rhesus macaques as a model, we demonstrate that the administration of pre-assembled SIV Rev-dependent lentiviral particles into SIVmac239-infected Indian rhesus macaques can lead to reduction of viral rebound upon ART termination. One of the injected animals, KC50, controlled plasma and CNS viremia to an undetectable level most of the time for over two years after ART termination. Surprisingly, detailed molecular and immunological characterization revealed that viremia control was concomitant with the induction of neutralizing antibodies (nAbs) following the administration of the Rev-dependent vectors. This study emphasizes the importance of neutralizing antibodies (nAbs) for viremia control [10–15], and also provides proof of concept that the Rev-dependent vector can be used to target viral reservoirs, including the CNS reservoirs, in vivo. However, future large-scale in vivo studies are needed to understand the potential mechanisms of viremia control induced by the Rev-dependent vector.
FSRW: fuzzy logic-based whale optimization algorithm for trust-aware routing in IoT-based healthcare
Authors: Xu Hui , Liu Wei-dong , Li Lu , Yao Deng-ju , Ma Lin
Published: July 2024

The Internet of Things (IoT) is an extensive system of interrelated devices equipped with sensors to monitor and track real world objects, spanning several verticals, covering many different industries. The IoT's promise is capturing interest as its value in healthcare continues to grow, as it can overlay on top of challenges dealing with the rising burden of chronic disease management and an aging population. To address difficulties associated with IoT-enabled healthcare, we propose a secure routing protocol that combines a fuzzy logic system and the Whale Optimization Algorithm (WOA) hierarchically. The suggested method consists of two primary approaches: the fuzzy trust strategy and the WOA-inspired clustering methodology. The first methodology plays a critical role in determining the trustworthiness of connected IoT equipment. Furthermore, a WOA-based clustering framework is implemented. A fitness function assesses the likelihood of IoT devices acting as cluster heads. This formula considers factors such as centrality, range of communication, hop count, remaining energy, and trustworthiness. Compared with other algorithms, the proposed method outperformed them in terms of network lifespan, energy usage, and packet delivery ratio by 47%, 58%, and 17.7%, respectively.
Safety, tolerability, pharmacokinetics and pharmacodynamics of milvexian with aspirin and/or clopidogrel in healthy participants
Authors: Perera Vidya , Abelian Grigor , Luettgen Joseph , Aronson Ronald , Li Danshi , Wang Zhaoqing , Zhang Liping , Lubin Susan , Merali Samira , Murthy Bindu
Published: July 2024

Milvexian, an oral activated Factor XI (FXIa) inhibitor, is in clinical studies where it may be combined with antiplatelet agents, including aspirin and/or clopidogrel, to prevent thromboembolic diseases. This phase I trial assessed safety, pharmacokinetics, and pharmacodynamics of milvexian coadministration with aspirin and/or clopidogrel in healthy participants through 3 drug-drug interaction studies using a 3-period, 3-treatment, crossover design. A total of 113 participants were randomized to receive milvexian (200 mg; twice daily for 5 days) or matched placebo coadministered with once-daily aspirin (325 mg for 5 days) and/or clopidogrel (Day 1: 300 mg; Days 2–5: 75 mg). Milvexian was safe and well tolerated, with and without aspirin and/or clopidogrel. Eight mild bleeding adverse events (AEs) were reported in 5 of 113 participants across various treatment arms. Peak and total exposures of milvexian were similar with or without clopidogrel and/or aspirin. Exposure-dependent prolongation of activated partial thromboplastin time and reduction of FXI clotting activity by milvexian were similar with coadministration of aspirin and/or clopidogrel. Milvexian, with or without coadministration of aspirin and/or clopidogrel, did not affect bleeding time or platelet aggregation. Administration of milvexian alone or with aspirin and/or clopidogrel was safe and well tolerated without increased incidence of AEs, including bleeding. Pharmacokinetic and pharmacodynamic effects of milvexian, including bleeding time, were similar with or without aspirin and/or clopidogrel.

ClinicalTrials.gov Identifier: NCT03698513.
Assessing VOC emissions from different gas stations: impacts, variations, and modeling fluctuations of air pollutants
Authors: Heidari Elham Alsadat , Sarkhosh Maryam , Alidadi Hosein , Najafpoor Ali Asghar , Esmaily Habibollah , Shamsara Elham
Published: July 2024

Gas stations distributed around densely populated areas are responsible for toxic pollutant emissions such as volatile organic compounds (VOCs). This study aims to measure VOCs emission from three different kinds of gas stations to determine the extent of pollution from the gas stations and the most frequent type of VOC compound emitted. The concentrations of ambient VOCs at three refueling stations with a different type of fuels in Mashhad were monitored. The result of this study showed that CNG fuel stations are less polluting than petrol stations. In all the studied sites, the highest concentrations were related to xylene isomers, irrespective of the fuel type. Total VOCs at the supply of both compressed natural gas (CNG) and gasoline stations was 482.36 ± 563.45 µg m−3. At a CNG station and a gasoline station, total VOC concentrations were 1363.4 ± 1975 µg m−3 and 410.29 ± 483.37 µg m−3, respectively. The differences in concentrations of toluene and m,p-xylene between the fuel stations can be related to the quality and type of fuel, vapor recovery technology, fuel reserves, dripless nozzles, traffic density in these stations, meteorological conditions and the location of sampling sites. The combination of a sine function and a quadratic function could model the fluctuation behavior of air pollutants like m,p-xylene. In all the sites, the highest concentrations were related to xylene isomers, irrespective of the type of fuel. The changing rate of m,p-xylene pollutant in each station was also modeled in this study.
PK/PD investigation of antiviral host matriptase/TMPRSS2 inhibitors in cell models
Authors: Gamba Dávid , van Eijk Nicholas , Lányi Katalin , Monostory Katalin , Steinmetzer Torsten , Marosi András , Rácz Anita , Bajusz Dávid , Kruhl Diana , Böttcher-Friebertshäuser Eva , Pászti-Gere Erzsébet
Published: July 2024

Certain corona- and influenza viruses utilize type II transmembrane serine proteases for cell entry, making these enzymes potential drug targets for the treatment of viral respiratory infections. In this study, the cytotoxicity and inhibitory effects of seven matriptase/TMPRSS2 inhibitors (MI-21, MI-463, MI-472, MI-485, MI-1900, MI-1903, and MI-1904) on cytochrome P450 enzymes were evaluated using fluorometric assays. Additionally, their antiviral activity against influenza A virus subtypes H1N1 and H9N2 was assessed. The metabolic depletion rates of these inhibitors in human primary hepatocytes were determined over a 120-min period by LC–MS/MS, and PK parameters were calculated. The tested compounds, with the exception of MI-21, displayed potent inhibition of CYP3A4, while all compounds lacked inhibitory effects on CYP1A2, CYP2C9, CYP2C19, and CYP2D6. The differences between the CYP3A4 activity within the series were rationalized by ligand docking. Elucidation of PK parameters showed that inhibitors MI-463, MI-472, MI-485, MI-1900 and MI-1904 were more stable compounds than MI-21 and MI-1903. Anti-H1N1 properties of inhibitors MI-463 and MI-1900 and anti-H9N2 effects of MI-463 were shown at 20 and 50 µM after 24 h incubation with the inhibitors, suggesting that these inhibitors can be applied to block entry of these viruses by suppressing host matriptase/TMPRSS2-mediated cleavage.
A systematic review of the impacts of remote patient monitoring (RPM) interventions on safety, adherence, quality-of-life and cost-related outcomes
Authors: Tan Si Ying , Sumner Jennifer , Wang Yuchen , Wenjun Yip Alexander
Published: July 2024

Due to rapid technological advancements, remote patient monitoring (RPM) technology has gained traction in recent years. While the effects of specific RPM interventions are known, few published reviews examine RPM in the context of care transitions from an inpatient hospital setting to a home environment. In this systematic review, we addressed this gap by examining the impacts of RPM interventions on patient safety, adherence, clinical and quality of life outcomes and cost-related outcomes during care transition from inpatient care to a home setting. We searched five academic databases (PubMed, CINAHL, PsycINFO, Embase and SCOPUS), screened 2606 articles, and included 29 studies from 16 countries. These studies examined seven types of RPM interventions (communication tools, computer-based systems, smartphone applications, web portals, augmented clinical devices with monitoring capabilities, wearables and standard clinical tools for intermittent monitoring). RPM interventions demonstrated positive outcomes in patient safety and adherence. RPM interventions also improved patients’ mobility and functional statuses, but the impact on other clinical and quality-of-life measures, such as physical and mental health symptoms, remains inconclusive. In terms of cost-related outcomes, there was a clear downward trend in the risks of hospital admission/readmission, length of stay, number of outpatient visits and non-hospitalisation costs. Future research should explore whether incorporating intervention components with a strong human element alongside the deployment of technology enhances the effectiveness of RPM. The review highlights the need for more economic evaluations and implementation studies that shed light on the facilitators and barriers to adopting RPM interventions in different care settings.
Normoglycemia and physiological cortisone level maintain glucose homeostasis in a pancreas-liver microphysiological system
Authors: Rigal Sophie , Casas Belén , Kanebratt Kajsa P. , Wennberg Huldt Charlotte , Magnusson Lisa U. , Müllers Erik , Karlsson Fredrik , Clausen Maryam , Hansson Sara F. , Leonard Louise , Cairns Jonathan , Jansson Löfmark Rasmus , Ämmälä Carina , Marx Uwe , Gennemark Peter , Cedersund Gunnar , Andersson Tommy B. , Vilén Liisa K.
Published: July 2024

Current research on metabolic disorders and diabetes relies on animal models because multi-organ diseases cannot be well studied with standard in vitro assays. Here, we have connected cell models of key metabolic organs, the pancreas and liver, on a microfluidic chip to enable diabetes research in a human-based in vitro system. Aided by mechanistic mathematical modeling, we demonstrate that hyperglycemia and high cortisone concentration induce glucose dysregulation in the pancreas-liver microphysiological system (MPS), mimicking a diabetic phenotype seen in patients with glucocorticoid-induced diabetes. In this diseased condition, the pancreas-liver MPS displays beta-cell dysfunction, steatosis, elevated ketone-body secretion, increased glycogen storage, and upregulated gluconeogenic gene expression. Conversely, a physiological culture condition maintains glucose tolerance and beta-cell function. This method was reproducible in two laboratories and was effective in multiple pancreatic islet donors. The model also provides a platform to identify new therapeutic proteins, as demonstrated with a combined transcriptome and proteome analysis.
Membrane vectorial lipidomic features of coral host cells’ plasma membrane and lipid profiles of their endosymbionts Cladocopium
Authors: Sikorskaya Tatyana V. , Ermolenko Ekaterina V. , Ginanova Taliya T. , Boroda Andrey V. , Efimova Kseniya V. , Bogdanov Mikhail
Published: July 2024

The symbiotic relationships between coral animal host and autotrophic dinoflagellates are based on the mutual exchange and tight control of nutritional inputs supporting successful growth. The corals Sinularia heterospiculata and Acropora aspera were cultivated using a flow-through circulation system supplying seawater during cold and warm seasons of the year, then sorted into host cells and symbionts and subjected to phylogenetic, morphological, and advanced lipid analyses. Here we show, that the lipidomes of the dinoflagellates Cladocopium C1/C3 and acroporide-specific Cladocopium hosted by the corals, are determined by lipidomic features of different thermosensitivity and unique betaine- and phospholipid molecular species. Phosphatidylserines and ceramiaminoethylphosphonates are not detected in the symbionts and predominantly localized on the inner leaflet of the S. heterospiculata host plasma membrane. The transmembrane distribution of phosphatidylethanolamines of S. heterospiculata host changes during different seasons of the year, possibly contributing to mutualistic nutritional exchange across this membrane complex to provide the host with a secure adaptive mechanism and ecological benefits.
Discovery of giant and conventional magnetofossils bookending Cretaceous Oceanic Anoxic Event 2
Authors: Wagner Courtney L. , Lascu Ioan , Self-Trail Jean M. , Gooding Tim , Livi Kenneth J. T. , Greger Gianna , Gardner Kristina , Wycech Jody , Dreier Mark , Oliver Tom
Published: July 2024

Conventional magnetofossils are the remains of magnetotactic bacteria and giant magnetofossils are the remains of iron biomineralizing organisms that have not yet been identified. We report the oldest robust conventional and giant magnetofossil records, ~97 Ma, from marine sediments drilled in Holland Park, Virginia, USA. The Holland Park core records the Cenomanian-Turonian boundary and Oceanic-Anoxic Event 2 (OAE2). Magnetic datasets indicate single domain magnetite within the clay-rich sediments bookending OAE2. Electron microscopy images from these intervals highlight conventional and giant magnetofossil morphologies, including three potentially new giant magnetofossil morphologies: seeds, squash, and spades. There is an overall high abundance and morphological disparity of magnetofossils at Holland Park. However, we observe abundance, disparity, and preservation changes between the magnetofossil assemblages bookending OAE2. Our observations provide clues toward understanding the ecological thresholds of the enigmatic organisms that produce giant magnetofossils and evidence that magnetofossils may be widely distributed in the geologic record.
NS2 induces an influenza A RNA polymerase hexamer and acts as a transcription to replication switch
Authors: Sun Junqing , Kuai Lu , Zhang Lei , Xie Yufeng , Zhang Yanfang , Li Yan , Peng Qi , Shao Yuekun , Yang Qiuxian , Tian Wen-Xia , Zhu Junhao , Qi Jianxun , Shi Yi , Deng Tao , Gao George F
Published: July 2024

Genome transcription and replication of influenza A virus (FluA), catalyzed by viral RNA polymerase (FluAPol), are delicately controlled across the virus life cycle. A switch from transcription to replication occurring at later stage of an infection is critical for progeny virion production and viral non-structural protein NS2 has been implicated in regulating the switch. However, the underlying regulatory mechanisms and the structure of NS2 remained elusive for years. Here, we determine the cryo-EM structure of the FluAPol-NS2 complex at ~3.0 Å resolution. Surprisingly, three domain-swapped NS2 dimers arrange three symmetrical FluPol dimers into a highly ordered barrel-like hexamer. Further structural and functional analyses demonstrate that NS2 binding not only hampers the interaction between FluAPol and the Pol II CTD because of steric conflicts, but also impairs FluAPol transcriptase activity by stalling it in the replicase conformation. Moreover, this is the first visualization of the full-length NS2 structure. Our findings uncover key molecular mechanisms of the FluA transcription-replication switch and have implications for the development of antivirals.
Novel mycophenolic acid precursor-based fluorescent probe for intracellular H2O2 detection in living cells and Daphnia magna and Zebrafish model systems
Authors: An Jongkeol , Park Sujeong , Jain Neha , Kim Youngsam , Nimse Satish Balasaheb , Churchill David G.
Published: July 2024

Innovative for the scientific community and attracting attention in the extensive biomedical field are novel compact organic chemosensing systems built upon unique core molecular frameworks.
Pd-Catalyzed cascade Heck cyclization/carbonylation of indoles with aryl formates: enantioselective construction of indolo[2,1-a]isoquinolines
Authors: Chi Dongmei , Qi Hongbo , Wang Leming , Chen Shufeng
Published: July 2024

A palladium-catalyzed enantioselective intramolecular Heck cyclization/carbonylation reaction has been developed, which utilizes formates as the source of CO to enantioselectively synthesize ester-substituted indolo[2,1-a]isoquinolines.
Construction of cationic meso-thiazolium-BODIPY AIE fluorescent probes for viscosity imaging in dual organelles
Authors: Tang Yu-Xin , Cao Yingmei , Shi Wen-Jing , Li Jin-Cheng , Lu Wei-Lin , Fan Ting , Zheng Liyao , Yan Jin-wu , Han Dongxue , Niu Li
Published: July 2024

We report meso-thiazolium-BODIPY-based red-shifted fluorescent rotors with viscosity-response and AIE, and successfully apply them for viscosity imaging in dual organelles.
Migration paths of the Na+-ion diffusion for minerals of the lovozerite group: crystallochemical and DFT modeling
Authors: Kabanova Natalia A.
Published: July 2024

For 11 minerals of the lovozerite group, theoretical investigations of Na+-ion migration were performed.
The nature of metallophilic interactions in closed-shell d8–d8 metal complexes
Authors: de Azevedo Santos Lucas , Wagner Timon , Visscher Klaas , Nitsch Jörn , Bickelhaupt F. Matthias , Fonseca Guerra Célia
Published: July 2024

d8–d8 square planar metal-complex dimers bind through electrostatic and dispersion interactions, augmented by HOMO–LUMO interactions between the metal centers (important for larger metals) and between the ligands (important for larger ligands).
Sub-picosecond photodynamics of small neutral copper oxide clusters
Authors: Rotteger Chase H. , Jarman Carter K. , Sobol Madison M. , Sutton Shaun F. , Sayres Scott G.
Published: July 2024

The excited state lifetimes of small neutral copper oxide clusters decrease with oxidation on the sub-picosecond timescale.
Bimetal loaded graphitic carbon nitride with synergistic enhanced peroxidase-like activity for colorimetric detection of p-phenylenediamine
Authors: Mu Jianshuai , Ren Mengjiao , Li Ning , Zhao Tengyi , Liu Zhong-Yi , Ma Jingwen , Lei Shulai , Wang Jiajun , Yang En-Cui , Wang Yan
Published: July 2024

Fe/Ni–CN exhibited efficient peroxidase-like activity via a bimetallic synergistic strategy and was used for colorimetric detection of p-phenylenediamine.
Dynamics and thermochemistry of the negatively charged clusters in a 2-hydroxyethylhydrazinium nitrate ionic liquid system
Authors: Zhou Wenjing , Liu Jianbo , Chambreau Steven D. , Vaghjiani Ghanshyam L.
Published: July 2024

Clustering thermochemistry of 2-hydroxyethylhydrazinium nitrate ionic liquid revealed by mass spectrometry and dynamics simulations.
Ion transport mechanisms in covalent organic frameworks: implications for technology
Authors: Lee Wonmi , Li Haochen , Du Zhilin , Feng Dawei
Published: July 2024

This review explores designing highly ion-conductive COFs for advanced electrochemical devices, merging theory and practice.
Advancing H2O2 electrosynthesis: enhancing electrochemical systems, unveiling emerging applications, and seizing opportunities
Authors: Deng Zhiping , Choi Seung Joon , Li Ge , Wang Xiaolei
Published: July 2024

Recent achievements in H2O2 electrosynthesis are reviewed, including electrocatalyst design, electrode optimization, electrolyte engineering, reactor exploration, potential applications, and integrated systems.
What can attribution methods show us about chemical language models?
Authors: Hödl Stefan , Kachman Tal , Bachrach Yoram , Huck Wilhelm T. S. , Robinson William E.
Published: July 2024

Chemical language models can be fine-tuned to predict properties, like water solubility, given molecular inputs. This work investigates how these predictions may be explained.
A novel MOF-808 derived material for oxidative desulfurization: the synergistic effect of hydrophobicity and electron transfer
Authors: Zhu Chengzhao , Zheng Miaomiao , Liao Mingyu , Jiang Nan , Xiao Yuanjie , Liu Jianbin , Zhang Linfeng , Guo Jia , Wu Huadong , Yan Hao
Published: July 2024

A functionalized T-MOF-808 was synthesized by hydrophobic modification with tetraethyl orthosilicate (TEOS) and chlorotrimethylsilane (TMCS). Then it was used as a support in the field of oxidative desulfurization with good catalytic activity.
An organic-organometallic CO-releasing material comprising 4,4′-bipyridine and molybdenum subcarbonyl building blocks
Authors: Calhau Isabel B. , Gomes Ana C. , Mendes Ricardo F. , Almeida Paz Filipe A. , Gonçalves Isabel S. , Pillinger Martyn
Published: July 2024

A Mo(CO)3/4,4′-bipyridine MOF has been prepared in near-quantitative yield by a simple reflux method and shown to retain the beneficial features of molybdenum carbonyl CO-releasing molecules.
Group 11 complexes of a bulky triazene ligand
Authors: George Tanner , Grant Tamika , Munhoz Isadora Schumann , Do Thai , Masuda Jason D.
Published: July 2024

The first Cu(i), Ag(i), and Au(i) complexes of the bulkiest neutral π-conjugated triazene ligand (L) are reported. Photolysis or hydrolysis of the L-Au(i)Cl forms either gold nanoparticles, or a stable[(SIPrNH)2Au(i)][Au(i)Cl2] salt, respectively.
Creation of spin switching in graphene oxide-based hybrid film materials with an anionic Fe(iii) 5Cl-salicyaldehyde–thiosemicarbazone complex
Authors: Spitsyna Nataliya G. , Lobach Anatoly S. , Blagov Maxim A. , Dremova Nadezhda N. , Dmitriev Alexei I. , Zhidkov Mikhail V. , Simonov Sergei V.
Published: July 2024

The present article describes the synthesis of hybrid composite film materials formed during the self-assembly process through non-covalent interactions of graphene oxide nanosheets with an anionic spin-crossover salt [Et4N][FeIII(5Cl-thsa)2].
Accurate and reliable thermochemistry by data analysis of complex thermochemical networks using Active Thermochemical Tables: the case of glycine thermochemistry
Authors: Ruscic Branko , Bross David H.
Published: July 2024

Active Thermochemical Tables (ATcT) are employed to resolve existing inconsistencies surrounding the thermochemistry of glycine and produce accurate enthalpies of formation for this system.
Investigation of signal enhancement in nanoparticle enhanced molecular LIBS of graphite
Authors: Soumyashree Swetapuspa , Kumar Prashant
Published: July 2024

In the present study, we have investigated the time evolution of molecular LIBS (MLIBS) and nanoparticle enhanced molecular LIBS (NEMLIBS) of graphite samples using 10 nm gold nanoparticles for delays up to 100 μs.
An asymmetrical Zr2CO/VSe2 heterostructure as an efficient electrocatalyst for the hydrogen evolution reaction
Authors: Hu Jisong , Liu Xiangyu , Wang Jiahao , Jin Jinxuan , Ouyang Ming , Fan Moshang , Zhang Rui , Ji Xiao , Miao Ling , Jiang Jianjun
Published: July 2024

Asymmetric Zr2CO/VSe2 heterostructures demonstrate remarkable hydrogen evolution reaction (HER) activity across various stacking angles, significantly outperforming the symmetric Zr2CO2 structure.
Two chiral CoIII and NiII complexes with identical ligands presenting different nonlinear optical responses
Authors: Wang Taoyu , Peng Yanhong , Zhang Zhiqiang , Gao Congli , Li Xi-Li
Published: July 2024

We demonstrate that the SHG and THG responses of the complexes can be regulated by metal ions.
The underlying molecular mechanism of topical fluid foam with microsphere assistance
Authors: Du Chunbao , Feng Zichun , Yin Changji , Jia Xingang , Zhao Yameng , Cheng Yuan
Published: July 2024

The stabilizing foam function of RM1 in fluid foam was connected to its size, surface chemical characteristics, and temperature, and RM1 could counteract the harmful effect of gravity on foam stability, improving the foam stability.
Development of a hydroxyapatite-based composite: Sr-doped HAp/NiO proven to be an efficient nanocatalyst for photocatalytic degradation of organic dye and photoreduction of Cr(vi)
Authors: Bharali Linkon , Sahu Susmita , Kalita Juri , Dhar Siddhartha Sankar
Published: July 2024

An efficient heterogeneous photocatalyst, Sr-doped HAp/NiO was utilized to degrade harmful Congo red dye and reduce carcinogenic Cr(vi) to less hazardous Cr(iii).
Facile synthesis of an α-Bi2O3/BiO2 heterojunction for enhanced piezoelectric catalytic degradation of dye wastewater
Authors: Hou Yuanwen , Tang Jia , Jiang Li , Xie Ning , Fu Hongquan , Zhang Juan , Gao Hejun , Xu Bin , Liao Yunwen
Published: July 2024

This study employed a one-step microwave method to fabricate an α-Bi2O3/BiO2 heterojunction with a narrow bandgap which exhibited a high efficiency in the degradation of methyl orange dye.
Unlocking the potential of a MOF-derived CaMoO4 electrode for high performance supercapacitor application
Authors: Rajkumar Palanisamy , Ramesh Joel Kingston , Thirumal Vediyappan , Iyer Maalavika S. , Princess R. Margrate Bhackiyavathi , Gnanamuthu R. M. , Yoo Kisoo , Kim Jinho
Published: July 2024

Deriving CaMoO4 from a bi-metallic metal–organic framework (MOF) has the potential to significantly enhance the electrochemical performance of the asymmetric supercapacitor.
Elucidating the electrochemical performance of manganese dioxide incorporated poly(methyl methacrylate) membranes for supercapacitors
Authors: Chikkatti Bipin S. , K. R. Adithya Maurya , Sajjan Ashok M. , Banapurmath Nagaraj R.
Published: July 2024

The performance of electrochemical supercapacitors is greatly affected by electrodes, which are considered one of the most significant components.
Application of mixed phosphorus/sulfur ligands based on terpenoids in Pd-catalyzed asymmetric allylic substitution and Rh-catalyzed hydrogenation
Authors: Gavrilov Konstantin N. , Chuchelkin Ilya V. , Gavrilov Vladislav K. , Firsin Ilya D. , Trunina Valeria M. , Shiryaev Alexey A. , Shkirdova Alena O. , Bermesheva Evgeniya V. , Tafeenko Victor A. , Chernyshev Vladimir V. , Zimarev Vladislav S. , Goulioukina Nataliya S.
Published: July 2024

Diamidophosphite-thioethers with terpenoid bridging moieties have been prepared and used in asymmetric transition-metal catalysis for the first time.
Microfluidic extensional flow device to study mass transfer dynamics in the polymer microparticle formation process
Authors: Sundar Suryavarshini , Nirmal Ghata , Borkar Suraj , Goel Sachin , Ramachandran Karthik , Kochhar Ransom , Hukkanen Eric J. , Chiarella Renato A. , Ramachandran Arun
Published: July 2024

An experimental study using microfluidics to understand the solvent extraction mass transfer dynamics in the formation of polymer microparticles.
Progress in multifactorial single-cell chromatin profiling methods
Authors: Stuart Tim
Published: July 2024

Chromatin states play a key role in shaping overall cellular states and fates. Building a complete picture of the functional state of chromatin in cells requires the co-detection of several distinct biochemical aspects. These span DNA methylation, chromatin accessibility, chromosomal conformation, histone posttranslational modifications, and more. While this certainly presents a challenging task, over the past few years many new and creative methods have been developed that now enable co-assay of these different aspects of chromatin at single cell resolution. This field is entering an exciting phase, where a confluence of technological improvements, decreased sequencing costs, and computational innovation are presenting new opportunities to dissect the diversity of chromatin states present in tissues, and how these states may influence gene regulation. In this review, I discuss the spectrum of current experimental approaches for multifactorial chromatin profiling, highlight some of the experimental and analytical challenges, as well as some areas for further innovation.
Kopfschmerz bei Medikamentenübergebrauch
Authors: Naegel Steffen
Published: July 2024

Der Kopfschmerz durch Medikamentenübergebrauch (MOH) ist eine weltweit
verbreitete und beeinträchtigende Erkrankung, die durch übermäßige Einnahme von
Akuttherapie entsteht und die Lebensqualität erheblich beeinträchtigen kann und
das obwohl z.B. einfache Informationen über Ursachen und Folgen der Erkrankung
dazu beitragen können, den MOH zu verhindern oder zu beenden. In den letzten
Jahren konnten viele neue Erkenntnisse zum Kopfschmerz durch
Medikamentenübergebrauch generiert werden. Zudem haben sich die
Diagnosekriterien und die Leitlinienempfehlungen umfassend gewandelt. Dieser
Artikel bietet einen umfassenden Überblick über die Klinik,
Definition/Klassifikation, Epidemiologie, Risikofaktoren, Pathophysiologie,
Kontroversen, Prävention und Behandlung des MOH.
Chemical Methods for the Construction of Spirocyclic β-Lactams and Their Biological Importance
Authors: Berry Shiwani , Bhalla Aman , Yadav Pooja
Published: July 2024

Spirocyclic β-lactams are a family of natural and synthetic chemicals with different biological activities, including antibacterial properties, and interact with critical physiological targets such as T-type calcium channels and acetyl-CoA cholesterol acyltransferase. Their unique chemical structure, combining a spiro ring system with a β-lactam group, offers promising opportunities for the targeted discovery of medications in medicinal chemistry. Spirocyclic β-lactams have the potential to be adaptable frameworks for developing novel therapeutic medicines with particular three-dimensional pharmacophoric characteristics and increased biological efficacy. Numerous methods are employed for the synthesis of spirocyclic β-lactams, such as cyclization, functional group modifications, asymmetric synthesis utilizing chiral catalysts and biomimetic approaches. In this short review, two distinct approaches describing recent syntheses of spirocyclic β-lactams (from 2021 to 2024) are discussed. The first is based on constructing the β-lactam ring, while the other entails transforming monocyclic β-lactams into spirocyclic structures. These methods include detailed reaction processes and descriptions of the biological functions of the target spirocycles. The applications of spirocyclic β-lactams in medicinal chemistry highlight their role in the synthesis of structurally diverse compounds with significant therapeutic potential, demonstrating creative chemical methods for building complex molecular structures.

1 Introduction

2 β-Lactam Ring Synthesis

3 Non-β-Lactam Ring Synthesis

4 Miscellaneous Examples

5 Conclusion and Outlook
Lewis Acid Mediated Synthesis of 4-Aminoquinoline Derivatives from 2-Aminobenzonitriles and Activated Alkynes via Aza-Michael and Annulation Reactions
Authors: Saikia Anil K. , Porashar Bikoshita
Published: July 2024

An efficient methodology for the synthesis of highly diverse 4-aminoquinoline derivatives from activated alkynes and 2-aminobenzonitriles mediated by Lewis acid is described. The reaction proceeds via sequential aza-Michael addition/intramolecular annulation to afford highly substituted 4-aminoquinolines in good yields. The reaction is operationally simple and has high atom-economy with broad substrate scope. The post synthetic application of the reaction provides 4H-benzo[de][1,6]naphthyridines.
Correlation of endoscopic ultrasound-guided portal pressure gradient measurements with hepatic venous pressure gradient: a prospective study
Authors: Martinez-Moreno Belén , Martínez Martínez Juan , Herrera Iván , Guilabert Lucía , Rodríguez-Soler María , Bellot Pablo , Miralles Cayetano , Pascual Sonia , Irúrzun Javier , Zapater Pedro , Palazón-Azorín José María , Gil Guillén Vicente , Jover Rodrigo , Aparicio José R.
Published: July 2024

Background Hepatic venous portal gradient (HVPG) measurement remains the gold standard for estimating portal pressure gradient (PPG). This study aimed to evaluate the correlation between endoscopic ultrasound (EUS)-guided PPG and HVPG in patients with chronic portal hypertension.

Methods Patients with chronic portal hypertension in whom HVPG assessment was clinically indicated were invited to undergo transjugular HVPG and EUS-PPG with a 22-G needle in separate sessions for comparison. Intraclass correlation coefficient (ICC) and the Bland–Altman method were used to evaluate the agreement between techniques.

Results 33 patients were included. No significant differences in technical success were observed: EUS-PPG (31/33, 93.9%) vs. HVPG (31/33, 93.9%). Overall, 30 patients who underwent successful EUS-PPG and HVPG were analyzed. Correlation between the two techniques showed an ICC of 0.82 (0.65–0.91). Four patients had major discrepancies (≥5 mmHg) between HVPG and EUS-PPG. No significant differences in adverse events were observed.

Conclusions The correlation between EUS-PPG and HVPG was almost perfect. EUS-PPG could be a safe and reliable method for direct PPG measurement in patients with cirrhosis and a valid alternative to HVPG.
Reha-Empfehlungen nach § 31 SGB XI: Empirie, Diskussion und
gesundheitspolitische Implikationen
Authors: Herberg Stephan , Zerth Juergen , Hammer Jonas , Teuteberg Frank
Published: July 2024

Hintergrund Das Prinzip „Rehabilitation vor Pflege“ ist ein
sozialrechtlicher Grundsatz. Einen wichtigen Stellenwert bei den
Rehabilitationsempfehlungen nimmt die Empfehlung des Medizinischen Dienstes (MD)
im Rahmen der Begutachtung (§ 31 SGB XI) ein. Bei rund drei Prozent seiner
Begutachtungen empfiehlt der MD die Durchführung einer Rehabilitation. Nur bei
jeder vierten bis fünften Empfehlung folgt der Empfehlung eine tatsächliche
Durchführung der Rehabilitationsmaßnahme.

Ziel der Arbeit Diskutiert werden soll anhand einer Versichertenbefragung
der Aspekt, ob die rehabilitativen Potentiale genutzt und ausgeschöpft werden,
die aus der Rehabilitationsempfehlung entstehen.

Material und Methoden Diese Arbeit untersucht insbesondere die Perspektive
der Versicherten, die einer Rehabilitationsmaßnahme zugestimmt haben und deren
Rehabilitation auch durchgeführt wurde. Nach Auswertung von 586 228
Routindatensätzen mit Pflegebegutachtungen des MD wurden im März 2023 1972
Befragungsbögen versandt, 1116 auswertbare Fragebögen konnten in die
Datenauswertung einbezogen werden. In sieben Fragen wurden die Befragten
gebeten, retrospektiv den Erfolg und die Zufriedenheit mit der Rehabilitation
insgesamt und der Wirksamkeit der durchgeführten Therapien einzuschätzen.

Ergebnisse Die Auswertung der Ergebnisse zeigt dabei, dass 87 Prozent der
Studienteilnehmer eine Rehabilitation wiederholen würden. Auch die Einschätzung
zum Reha-Erfolg in Bezug auf den längeren Verbleib in der eigenen Häuslichkeit
hat Gewicht. Auf der anderen Seite werden nach wie vor nur rund 10 Prozent der
durchgeführten Rehabilitationen ambulant durchgeführt.

Schlussfolgerungen Als eine Begründung für die geringe Teilnahme an
Rehabilitationsmaßnahmen wurde bisher angenommen, dass Pflegebedürftige im Jahr
vor der Reha-Empfehlung schon Maßnahmen der Rehabilitation erhalten hätten. Die
Ergebnisse der Auswertung der Routinedaten einer Krankenkasse können diese
Annahme jedoch widerlegen. So richtet sich der Blick auf die angebotenen und
dann wahrgenommen Möglichkeiten, Reha-Leistungen in Anspruch zu nehmen. Es gilt
zu diskutieren, ob die in Deutschland noch starke Ausrichtung auf stationäre
Rehabilitation sowohl medizinisch als auch mit Blick auf die Präferenzen der
Rehaberechtigten zeitgemäß sind. Aspekte für individuelle, ambulante und ggf.
mobile Rehabilitationsangebote können daher geeignetere Mittel der Wahl sein,
die auch den Ansprüchen an individuelle Mobilität und Autonomie und dem Wunsch,
Reha in ein häusliches Umfeld einzupassen, gerecht werden.
Quadriceps Architectural Adaptations in Team Sports Players: A
Meta-analysis
Authors: Pecci Javier , Sañudo Borja , Sanchez-Trigo Horacio , Reverte-Pagola Gonzalo , Pareja-Galeano Helios
Published: July 2024

Resistance training is the most effective strategy to modify muscle architecture,
enhancing sport performance and reducing injury risk. The aim of this study was
to compare the effects of high loads (HL) versus lower loads (LL), maximal
versus submaximal efforts, and high frequency (HF) versus low frequency (LF) on
quadriceps architectural adaptations in team sports players. Five databases were
searched. Vastus lateralis thickness, fascicle length and pennation angle, and
rectus femoris thickness were analyzed as main outcomes. Overall, resistance
training significantly improved muscle thickness and pennation angle, but not
fascicle length. LL led to greater fascicle length adaptations in the vastus
lateralis compared to HL (p=0.01), while no substantial differences were found
for other load comparisons. Degree of effort and training frequency did not show
meaningful differences (p>0.05). In conclusion, LL lengthen the fascicle to a
greater extent than HL, and training with LL twice a week could maximize
architectural adaptations, whereas the degree of effort does not appear to be a
determinant variable on quadriceps architectural adaptations.
A termografia no apoio ao diagnóstico de disfunções no tendão patelar: Uma revisão sistemática
Authors: Barros Sálvio Tadeu Correia de , Neves Eduardo Borba , Brioschi Marcos Leal
Published: July 2024

Objetivo O presente trabalho teve como objetivo analisar o uso das imagens térmicas como ferramenta de auxílio ao diagnóstico de disfunções no tendão patelar.

Métodos Realizou-se uma revisão sistemática da literatura, seguindo o protocolo PRISMA com busca nas bases de dados internacionais: Web of Science, SCOPUS, e Pubmed
. Foram utilizados descritores em Inglês com a seguinte combinação ("thermal imaging" OR thermography OR "Infrared image" OR "Skin Temperature" OR "thermal image" OR "Infrared imaging") AND ("patellar tendon"). A avaliação da qualidade metodológica dos trabalhos selecionados foi realizada por dois avaliadores de forma independente pelo instrumento Quality Assessment of Diagnostic Accuracy Studies (QUADAS-2).

Resultados Foram selecionados seis artigos originais. Três trabalhos avaliaram as alterações da temperatura da pele em situações patológicas. Outros dois trabalhos avaliaram a confiabilidade e reprodutibilidade da termografia especificamente na região do tendão patelar, e um artigo monitorou a temperatura da pele antes e após dois protocolos de treinamento físico.

Conclusão Pode-se concluir que o uso das imagens térmicas se mostrou uma excelente ferramenta de apoio ao diagnóstico a disfunções na região do tendão patelar, bem como para o monitoramento das alterações fisiológicas dessa região também em condições não patológicas, como durante a prática de treinamento físico.
A hiatus in the rivalry between Pierre Marie and Jules Dejerine: a collaborative study on sensory disorders by Andre Pierre Marie and Gustave Roussy
Authors: Camargo Carlos Henrique Ferreira , Cassou Emanuel , Germiniani Francisco Manoel Branco , Teive Hélio Afonso Ghizoni
Published: July 2024

Personal and professional rivalries involving prominent neurologists mark the history of nineteenth-century French neurology. One of the great examples is the feud between Pierre Marie and Jules Dejerine. The dispute between the two, nevertheless, did not prevent Pierre Marie's son, André Marie, and Gustave Roussy – one of Dejerine's favorite pupils, from collaborating on significant research that led to the doctoral dissertation by Andre Marie regarding sensory disturbances associated with painful hemiagnosia found in thalamic lesions.
Soft skills: students and employers crave
Authors: Romanenko Yulia N. , Stepanova Maria , Maksimenko Nadezhda
Published: July 2024

This study focuses on soft skills – over-professional competencies that are assessed on a par with professional competencies in today’s world, including for employment purposes. At ITMO University these skills are taught as a separate block of compulsory subjects for students’ choice. The aim of the research was to find out whether teaching soft skills meets the requirements of their future employers. For this purpose, an analysis of vacancies on a popular job search platform was conducted, followed by a public opinion survey of both students and employers. A large-scale study of graduates’ experiences and the labor market in Russia and the Northwestern Federal District in particular was conducted. All the results of the three phases of the work were used to draw conclusions about the development of the study and the application of the results. In general, it was shown that the trajectory of learning and development of soft skills in students should be supported, and future employers appreciate this experience in actual work.
A professional development course inviting changes in preservice mathematics teachers’ integration of technology into teaching: the lens of instrumental orchestration
Authors: Tan Qi , Yuan Zhiqiang
Published: July 2024

Information and Communication Technologies (ICTs) can provide rich learning opportunities in classroom teaching, which requires teachers’ effective instrumental orchestrations. However, there is a lack of research regarding the development of teachers’ instrumental orchestrations. In this study, we designed and implemented a professional development course, aiming to explore whether the course could change preservice mathematics teachers’ instrumental orchestrations. To this end, an analytical framework of instrumental orchestrations within a GeoGebra environment was established. Data were collected from Chinese preservice mathematics teachers, including the videotapes of their simulated lessons, GeoGebra files, written documents, self-reflections, online speaking, etc. In the results, three participants’ changes in instrumental orchestrations were presented as main cases. It was found that the three preservice mathematics teachers’ types of instrumental orchestrations did not change, but the frequencies of those increased significantly. The changes in didactical configurations were mainly reflected in the layout of GeoGebra, and the changes in exploitation modes were mainly manifested in the techniques teachers use and the management of mathematics tasks. In addition, it was revealed that theoretical support (instrumental approach), technical support (knowledge about using GeoGebra), and community support (“Same Content Different Designs” activity and communicating and discussing with others) were useful course elements inviting changes in instrumental orchestrations. In this regard, this study contributes to providing a promising professional development course that can be used in teacher training so as to improve teachers’ instrumental orchestrations.
Transitive nonlocal games
Authors: Kar Prem Nigam , Prakash Jitendra , Roberson David E.
Published: July 2024

We study a class of nonlocal games, called transitive games, for which the set of perfect strategies forms a semigroup. We establish several interesting correspondences of bisynchronous transitive games with the theory of compact quantum groups. In particular, we associate a quantum permutation group with each bisynchronous transitive game and vice versa. We prove that the existence of a C*-strategy, the existence of a quantum commuting strategy, and the existence of a classical strategy are all equivalent for bisynchronous transitive games. We then use some of these correspondences to establish necessary and sufficient conditions for some classes of correlations, that arise as perfect strategies of transitive games, to be nonlocal.
Insights into chemical kinetics of hybrid chemical reaction models in hypersonic rarefied flow
Authors: G. Gokul , G. Malaikannan
Published: July 2024

The present research investigates the effect of chemical reaction models on the re-entry vehicle and its aerothermodynamic properties. Chemically reacting flows influence the flow field structure and the aerothermal properties of the re-entry vehicle significantly greater than non-reacting flows. This study employs the Direct Simulation Monte Carlo (DSMC) method to analyze the impact of chemical reactions on re-entry vehicles. Chemical reaction models, namely, Total Collision Energy (TCE), Quantum-Kinetic (QK), hybrid TCE/QK, and hybrid QK/TCE, are used in simulation. The Stochastic PArallel Rarefied-gas Time-accurate Analyzer DSMC code is used for the simulations with the re-entry velocity of 7600 m/s and the freestream temperature of 208.4 K at an altitude of 105 km. The simulations contain 19 chemical reactions with five species: N2, O2, NO, N, and O. The variable hard sphere model is used for the particle–particle collision, and the Cercignani–Lampis–Lord model is used for the modeling of the gas–surface interactions. The simulation results show the hybrid QK/TCE and hybrid TCE/QK models have very good agreement with the QK and TCE models and, moreover, no changes in the flow field structure between the chemical reaction models. The peak temperature behind the shock wave predicted by the QK model is lower compared to other chemical reaction models because of the higher dissociation rates, whereas the hybrid QK/TCE model slightly overpredicts temperature compared to other chemical reaction models due to the lower dissociation rates. The hybrid QK/TCE model shows more computationally efficient than the QK and TCE models due to lower gas reaction tallies.