bluuebunny/crossref_metadata_2025 huggingface dataset:
Traffic Classification for Network Slicing in Mobile Networks
Authors: Gabilondo Álvaro , Fernández Zaloa , Viola Roberto , Martín Ángel , Zorrilla Mikel , Angueira Pablo , Montalbán Jon
Published: March 2022

Network slicing is a promising technique used in the smart delivery of traffic and can satisfy the requirements of specific applications or systems based on the features of the 5G network. To this end, an appropriate slice needs to be selected for each data flow to efficiently transmit data for different applications and heterogeneous requirements. To apply the slicing paradigm at the radio segment of a cellular network, this paper presents two approaches for dynamically classifying the traffic types of individual flows and transmitting them through a specific slice with an associated 5G quality-of-service identifier (5QI). Finally, using a 5G standalone (SA) experimental network solution, we apply the radio resource sharing configuration to prioritize traffic that is dispatched through the most suitable slice. The results demonstrate that the use of network slicing allows for higher efficiency and reliability for the most critical data in terms of packet loss or jitter.
Comparison of Ground-Based Global Horizontal Irradiance and Direct Normal Irradiance with Satellite-Based SUNY Model
Authors: Ayaz Adnan , Ahmad Faraz , Irfan Mohammad Abdul Aziz , Rehman Zabdur , Rajski Krzysztof , Danielewicz Jan
Published: March 2022

Since the fossil reserves are depleting day by day, the trend of modern energy sector is going towards renewable energy. The demand of solar power plants is therefore at the peak nowadays across the globe. However, the construction of these plants is extremely dependent on feasibility study to estimate the real solar potential before installing it in any region. To evaluate the solar energy potential of Peshawar region in Pakistan, Ground-based global horizontal irradiance (GHI) and direct normal irradiance (DNI) were compared with satellite-based model SUNY. Ground measurements were done at the University of Engineering and Technology Peshawar (UET Peshawar) with the help of pyranometer and shadowband irradiometer. Comparison of the data showed that there was a maximum difference of 42.90% in ground and satellite-based GHI in the month of December. Minimum difference in GHI was found for the month of March that was −3.83%. Moreover, ground-based GHI was overestimated in the month of February, March, and April, while in rest of the months, satellite values of GHI exceeded the ground measurements. Similarly, maximum difference of 55.86% was found in the month of November between ground and satellite-based DNI while minimum difference of −3.34% was seen in DNI in the month of March between the two data. Furthermore, satellite-based DNI was underestimated in the months of February, March, and April while in rest of the months it was overestimated compared to ground measurements. In addition to this, correlation of ground and satellite-based GHI and DNI showed R2 value of 0.8852 and 0.4139, respectively. The results of this study revealed that the difference between ground measurements and satellite values was considerable and hence real time measurements are necessary to properly estimate solar energy resource in the country.
Lightning Failure Risk Assessment of Overhead Transmission Lines Based on Modified Dempster–Shafer Theory
Authors: Liu Jie , Jia Boyan , Zhang Zhimeng , Wang Zimo , Wang Ping , Geng Jianghai
Published: March 2022

Lightning has a certain degree of potential threat to the safe operation of overhead transmission lines. In order to make targeted lightning protection arrangements and reduce the impact of lightning on overhead transmission lines, it is necessary to conduct lightning risk assessments on overhead transmission lines. This paper proposes a lightning failure risk assessment method for overhead transmission lines based on a modified Dempster–Shafer theory. First, analyze the historical lightning failure data of the line, determine the lightning failure impact factors, and use confidence to express the relationship between the lightning failure and the impact factor; then, use entropy weight theory and gray relational theory to calculate the value of mass function, and modify it on this basis; finally, use Dempster–Shafer theory to determine the trust degree and fit this with the calculated lightning trip rate to produce the risk assessment. This paper analyzes the lightning failure data of overhead transmission lines in some areas of Hebei Province. The results show that, compared with the evaluation method of the Dempster–Shafer theory, the accuracy of the evaluation is improved to a certain extent after correcting the mass function value. It can be seen that this method can integrate and comprehensively consider different data and can provide a reference for preventing damage to transmission lines by lightning strike weather.
Spray Behavior, Combustion, and Emission Characteristics of Jet Propellant-5 and Biodiesel Fuels with Multiple Split Injection Strategies
Authors: Baek Hyun Min , Lee Hyung Min
Published: March 2022

This study focuses on an analysis of the spray behavior, combustion, and emission characteristics of jet propellant-5 (JP-5) and biodiesel fuels with single-injection timing and multiple split injection strategies in a common rail direct injection (CRDI) single-cylinder diesel engine system. The analysis includes visualization of the spray and combustion. Multiple split injection strategies (e.g., double, triple, quadruple, and quintuple) were considered by equally distributing the fuel injection amount within the single-injection. Injection of biodiesel has a delayed start (0.2 ms) as well as shorter spray tip penetration compared with JP-5. As the fuel injection timing was approached to the top dead center (TDC), the engine performance and combustion efficiency improved. Retarding the injection timing contributed to an increase in carbon dioxide (CO2) (JP-5: max. 2.6% up, BD100: max. 1.5% up) and a decrease in carbon monoxide (CO) (JP-5: max. 93% down, BD100: max. 91% down) and nitrogen oxides (NOx) (JP-5: max. 83% down, BD100: max. 82% down). In comparison with JP-5, biodiesel showed disadvantages from the point of its combustion and emission characteristics for all injection timings. The quadruple-injection strategy, in which fuel injection was performed four times, showed excellent combustion, engine performance, and combustion efficiency. The CO2 emissions were highest with the quadruple-injection strategy (JP-5: 6.6%, BD100: 5.8%). The CO emissions of biodiesel decreased as the pulses of split injection extended, and a significant reduction of 83.8% was observed. NOx increased as the number of split injections increased (JP-5: max. 37% up, BD100: max. 52% up). JP-5 was a longer ignition delay than that of biodiesel from combustion flame visualization results. The final combustion in the multiple-injection strategy showed a typical diffusion combustion pattern.
Processing Studies on Banded Hematite Quartzite’s of Sandur Sciht, Karnataka, India
Authors: Swamy Aspari Kumara , Nikkam Suresh , Kumar Palthur Sharath
Published: March 2022

The greater demand for high-quality iron ores has forced the iron and steel industries to utilize low-grade iron ores, such as banded hematite quartzite (BHQ). In the present work, a striped hematite quartzite sample from the Haraginadoni area, in the Sandur schist belt, Ballari District, Karnataka, India, was subjected to characterization studies and conventional mineral processing methods to produce pellet-grade concentrate, assayed as Fe > 63.0%, SiO2 + Al2O3 < 7%, (Al2O3/SiO2 < 0.5). The sample was analyzed as 35.70% Fe, 47.44% SiO2, 0.75% Al2O3, 0.06% Mn, 0.07% TiO2, 0.03% P, 0.02% S, and 0.83% LOI. We focused on two routes of beneficiating BHQ samples: (1) conventional gravity followed by reverse floatation and (2) magnetic separation followed by cleaning of magnetic concentrate by reverse floatation. Route 1, achieved pellet-grade concentrate through assaying, and was 63.73% Fe, 6.20% SiO2, 0.19% Al2O3, 0.03% Al2O3/SiO2, and 0.23% LOI, D80 45 µm, with 70.1% Fe recovery and 62.8% concentration efficiency at 39.6 wt% yield. Using Route 2, the process consisted of WHIMS at −74 µm, D80 54 µm, 10,000 Gauss, and with a 3 mm ball matrix, followed by flotation of the WHIMS concentrate, which produced a concentrate through assaying and was 63.34% Fe, 6.30% SiO2, 0.20% Al2O3 (0.03 Al2O3/SiO2), and 0.20% LOI with 77.4% Fe recovery, achieving a 68.8% concentration efficiency at 44.0 wt% yield, meeting pellet-grade specifications. Comparing and analyzing both routes for the concentration methods, Route 2, i.e., WHIMS and the reverse flotation of WHIMS concentrate, was amenable compared to Route 1.
John II Komnenos (1118–1143)
Authors: Lau Maximilian Christopher George
Published: March 2022

John II Komnenos was the son of Emperor Alexios I Komnenos and Eirene Doukaina, and brother of Princess Anna Komnene, the author of the Alexiad. Born in 1087, he was crowned soon after his fifth birthday as co-emperor with his father, and in 1105, he was married to Piroska Árpád, daughter of King Ladislaus I of Hungary and Adelaide of Rheinfelden. He is principally known for continuing his father’s work of stabilising Byzantium after the crises of the eleventh century. This included major wars of defence and conquest in both the Balkans and Anatolia, and especially a major eastern expedition in 1137–1139. During this campaign, he conquered Cilicia, but he was recalled to defend his borders against the Turks before he could make further conquests in Syria and bring the crusader states under his aegis. He died in a hunting accident just before he returned to Syria, with intentions to go to Jerusalem as well. His best-known iconographic representation is a mosaic of him and his wife in the Great Church of Sophia. Whilst there is also an image of him in a contemporary ornate gospel book, his most common representations are found on his many coin issues and seals.
Effects of Teff-Based Sourdoughs on Dough Rheology and Gluten-Free Bread Quality
Authors: Chochkov Rosen , Savova-Stoyanova Daniela , Papageorgiou Maria , Rocha João Miguel , Gotcheva Velitchka , Angelov Angel
Published: March 2022

Production of gluten-free bread (GFB) with good quality characteristics represents a technological challenge. Our study aimed to obtain nongluten bread from cereals and pseudocereals with applying single cultures of Pediococcus acidilactici, Pediococcus pentosaceus and Enteroccocus durans as sourdoughs. The effect of sourdoughs on the quality traits of gluten-free (GF) dough and GFB was explored. The structural and baking properties of GF dough composed of teff, rice, corn, and sorghum flours were improved by adding xanthan gum (0.6%), guar gum (1.0%) and carboxymethyl cellulose (1.0%). The tested strains reached 108 cfu/g in teff flour and produced sourdoughs with a pleasant lactic aroma. The sourdough-fermented doughs were softer and more elastic compared to control dough and yielded reduced baking loss. Strain Enterococcus durans ensured the best baking characteristics of GF dough and the highest softness of the GFB during storage. Strain Pediococcus pentosaceus had the most pronounced positive effect on aroma, taste and aftertaste. Pan baking was found to be more appropriate to obtain stable shape and good-looking products. A careful starter culture selection is necessary for GFB development since a significant effect of strain specificity on dough rheology and baking characteristics was observed.
Impact of the Variety of Tef [Eragrostis tef (Zucc.) Trotter] on Physical, Sensorial and Nutritional Properties of Gluten-Free Breads
Authors: Villanueva Marina , Abebe Workineh , Pérez-Quirce Sandra , Ronda Felicidad
Published: March 2022

Tef is currently being incorporated into a wide range of foodstuff due to its high nutritional profile. This study tries to fill the information gap on the effect of tef varieties on physico-chemical, nutritional and sensorial quality of gluten-free bread. Maize starch replacement at 50, 75 and 100 g/100 g level by tef flour from three Ethiopian varieties (DZ-Cr-37, DZ-Cr-387 and DZ-01-99) resulted in viable gluten-free breads with acceptable sensory properties, higher mineral content and lower glycemic response. Tef cultivar type and blending level significantly affected bread quality. The 50% and 75% substitution levels and the DZ-Cr-37 variety led to the highest bread volumes with the lowest firmness. Breads made with DZ-01-99 variety were darker and with more reddish crust and crumb hues than those made with the other varieties. Breads from 100% DZ-Cr-37 achieved the highest hedonic scores for color, odor, taste and texture. The Ca, Fe and Mg contents of the breads made with 100% tef were 13, 40 and 30 times, respectively, higher than those of the control bread (100% maize starch), indicating tef could be used as an excellent source of these important minerals. In addition, the rapidly digestible starch content decreased up to 28% in breads fortified with tef flour.
Water–Energy–Food Nexus and Life Cycle Thinking: A New Approach to Environmental and Nutritional Assessment of Potato Chips
Authors: Fernández-Ríos Ana , Laso Jara , Amo-Setién Francisco José , Abajas-Bustillo Rebeca , Ortego-Mate Carmen , Fullana-i-Palmer Pere , Bala Alba , Batlle-Bayer Laura , Balcells Merce , Puig Rita , Aldaco Rubén , Margallo María
Published: March 2022

The water–energy–food (WEF) nexus has become a key concept to promote the cross-sectoral coordination toward sustainable development. In particular, understanding the interdependences of these pillars, as well as addressing a life cycle perspective, is essential when evaluating food production systems. This study explores the environmental impacts and nutritional quality of potato chips, addressing life cycle thinking and a WEF nexus approach. For this purpose, the combined application of life cycle assessment (LCA) and the Nutrient-Rich Food 9.3 (NRF9.3) index was considered to identify the main environmental hotspots and advanced opportunities. The results indicated a major contribution of the cultivation stage on water use, whereas the processing accounted for most of the impacts in energy-related indicators and eutrophication potentials. Improvement opportunities reside in the joint application of drip irrigation, allowing to achieve important water savings, as well as the use of natural gas or pellets instead of diesel, which constitute cleaner energy sources. On the other hand, a poor nutritional density of potato chips became evident from the quantification of the NRF9.3, which can be significantly improved if potatoes undergo a roasted process instead of frying.
Risk Aversion, Managerial Reputation, and Debt–Equity Conflict
Authors: Dodonova Anna
Published: March 2022

When a firm finances a new project by issuing debt, it has an incentive to invest in excessively high-risk projects because shareholders enjoy all the benefits in case the project is successful but have limited liability when it fails. Anticipating such behavior, creditors may require a higher interest rate or may even refuse to provide capital. This debt–equity conflict is alleviated by the fact that most investment decisions are made by risk-averse managers who are not as well diversified as shareholders. This paper investigates the debt–equity conflict in firms in which the managers have an unobservable degree of risk averseness. Since managerial risk averseness is a desirable quality, such asymmetric information makes managers undertake actions that increase the market’s perception of them as being highly risk-averse. Consequently, such reputation building leads to a lower number of excessively high-risk projects being undertaken. This paper compares the entrepreneurial economy, in which managers are the sole owners of the firms, with the corporate economy, in which managers are hired by shareholders. Using the overlapping generations model, this paper shows that managerial reputation building can partially resolve the debt–equity conflict and improve efficiency in both economies; however, such improvement is larger in the entrepreneurial economy.
Case Report: A Detailed Phenotypic Description of Patients and Relatives with Combined Central Hypothyroidism and Growth Hormone Deficiency Carrying IGSF1 Mutations
Authors: Elizabeth Melitza S. M. , Hokken-Koelega Anita , Visser Jenny A. , Joustra Sjoerd D. , de Graaff Laura C. G.
Published: March 2022

In recent years, variants in immunoglobulin superfamily member 1 (IGSF1) have been associated with congenital hypopituitarism. Initially, IGSF1 variants were only reported in patients with central hypothyroidism (CeH) and macroorchidism. Later on, IGSF1 variants were also reported in patients with additional endocrinopathies, sometimes without macroorchidism. We studied IGSF1 as a new candidate gene for patients with combined CeH and growth hormone deficiency (GHD). We screened 80 male and 14 female Dutch patients with combined CeH and GHD for variants in the extracellular region of IGSF1, and we report detailed biomedical and clinical data of index cases and relatives. We identified three variants in our patient cohort, of which two were novel variants of unknown significance (p.L570I and c.1765+37C>A). In conclusion, we screened 94 patients with CeH and GHD and found variants in IGSF1 of which p.L570I could be of functional relevance. We provide detailed phenotypic data of two boys with the p.C947R variant and their large family. The remarkable phenotype of some of the relatives sheds new light on the phenotypic spectrum of IGSF1 variants.
Effects of Situation-Based Flipped Learning and Gamification as Combined Methodologies in Psychiatric Nursing Education: A Quasi-Experimental Study
Authors: Kim Haeran , Kim Boyoung
Published: March 2022

In psychiatric nursing courses, students learn about patients with mental illnesses or types of distress that may not be common in their daily lives. Consequently, some students experience difficulties interacting with patients. Therefore, new learning models that depart from the traditional one-way learning methods, engage students in clinical settings, and increase their motivation are needed. Situation-based flipped learning combined with gamification can improve nursing students’ care for patients with mental health problems. A total of 102 nursing students from a university in G Metropolitan City, Korea were randomly and equally divided into experimental and control groups. The experimental group participated in an eight-week psychiatric nursing program that included situation-based flipped learning combined with gamification. The control group participated in the traditional team-based lectures. After the program, both groups’ learning attitudes, problem-solving abilities, and empathetic responses were measured. The experimental group showed improved problem-solving (F = 4.012, p = 0.048) and empathetic abilities (t = −2.014, p = 0.047) after participating in situation-based flipped learning combined with gamification. The program was effective in helping students empathize with their patients and improve their problem-solving skills. Future curricula should be developed to incorporate flipped learning to nurture the practical competencies required for medical professionals, particularly in psychiatric nursing education.
Severe COVID-19 Infection Management in a Patient with Mild Haemophilia—A Case Report
Authors: Anžej Doma Saša , Lukič Milica
Published: March 2022

Patients with haemophilia present a significant challenge when admitted into the intensive care unit. To prevent haemorrhagic complications related to the infection or due to invasive procedures factor (F) VIII/IX must be substituted. As thromboembolic complications are frequent among critically ill COVID-19 patients, thromboprophylaxis is also applied to patients with haemophilia. This requires careful monitoring of FVIII/IX activity as well as other haemostatic parameters, such as D-dimer and antiXa. We describe a 44-year old patient with mild haemophilia A (FVIII activity of 6%), who required a prolonged intensive care unit stay due to a severe SARS-CoV-2 infection. FVIII was substituted via boluses, and dalteparin was given according to recommendations. The patient successfully recovered from the disease.
3D Digital Technologies for the Elaboration of a Replica of a Dermatological Didactic Model Belonging to the Olavide Museum from the Original Mould
Authors: Hernández-Muñoz Óscar , Aranda Gabrielli David , Maruri Palacín Amaya , Sterp Moga Emanuel , Sánchez-Ortiz Alicia
Published: March 2022

The Olavide Museum in Madrid, which was founded in the 19th century, preserves one of the most important collections in the world of three-dimensional dermatological models made of polychrome beeswax. These models have been used for the training of numerous generations of dermatologists in Spain. Unfortunately, many of the figures were preserved in precarious conditions during the time that the museum was closed in the middle of the 20th century, and some could not be found after its reopening. In this paper, we show a method for the recovery of a missing model of which only the original plaster cast remains. For this purpose, we use the combination of a structured light scanner and 3D printing, together with traditional techniques, to reproduce a copy of the original cast, in order to prevent its deterioration during the wax casting. As a result of this study, a highly realistic figure was obtained, which represented, in great detail, the small superficial reliefs of the skin lesions, as well as their colour. The conclusion of this research is that it is possible to recreate, with precision, a didactic model in beeswax from its mould, without the need to use the mould in the process, which avoids any risk of deterioration in the process.
Evaluation of Compact Tomato Cultivars for Container Gardening Indoors and under Sunlight
Authors: Cruz Stephanie , van Santen Edzard , Gómez Celina
Published: March 2022

Numerous compact tomato cultivars are available for home gardening. However, evaluations under different environmental conditions are limited. The aim of this study was to characterize the growth and productivity of 20 compact tomato cultivars grown indoors under environmental conditions that resembled a residential space (11 mol·m−2·d−1 of white light, constant 22 °C, and moderate relative humidity) or in a greenhouse with sunlight only. Plants in the greenhouse were generally larger and yielded more fruit than those grown indoors, likely due to the various differences in environmental conditions and corresponding effects of water and nutrient availability. Considering growth and yield variables, all cultivars evaluated in this study are recommended for outdoor gardening. However, ‘Little Bing’, ‘Sweet SturdyTM F1—Grace’, ‘Sweet SturdyTM F1—Jimmy’, ‘Sweet SturdyTM F1—Jo’, and ‘Tarzan F1′ are likely too large to be grown in most space-limited indoor environments. Furthermore, ‘Little Bing’, ‘Rosy Finch’, ‘Sweet ‘n’ Neat Yellow’, and ‘Yellow Canary’ were affected by intumescence when grown indoors, which could negatively affect gardening experiences until recommendations to mitigate this disorder become available. Results from this study provide baseline information for the use of compact tomato cultivars for container gardening indoors and under sunlight.
Influence of Socio-Economic Factors and Region of Birth on the Risk of Preeclampsia in Sweden
Authors: Mattsson Kristina , Juárez Sol , Malmqvist Ebba
Published: March 2022

Objectives: To investigate the association between socio-economic factors and the risk of preeclampsia in Sweden, specifically investigating if this relationship is confounded by maternal region of birth. Study design: All singleton births between 1999 and 2009 in an ethnically diverse area in southern Sweden, totaling 46,618 pregnancies, were included in this study. The data on maternal pregnancy outcomes were retrieved from a regional birth register and socio-economic variables from Statistics Sweden. The risk ratios for preeclampsia were calculated for educational level and household disposable income, adjusting for maternal region of birth, maternal age, body mass index, parity, and smoking. Results: Low income levels were associated with a higher risk for preeclampsia, adjusted risk ratio (aRR) = 1.25 (95% confidence interval [CI]: 0.99, 1.59) and aRR = 1.36 (95% CI: 1.10, 1.68) for the two lowest quintiles, respectively, compared to the highest. There was an educational gradient in preeclampsia risk, although not all categories reached statistical significance: aRR = 1.16, (95% CI: 0.89–1.50) for low educational attainment and aRR = 1.23 (95% CI: 1.08, 1.41) for intermediate educational attainment compared to women with highest education. The socio-economic gradient remained after adjusting for region of birth. There was a lower risk for preeclampsia for women born in Asia, aRR = 0.60 (95% CI: 0.47, 0.75), regardless of socio-economic position. Conclusion: An increased risk for preeclampsia was seen for women with measures of lower socio-economic position, even in a universal, government-funded healthcare setting. The relationship was not explained by region of birth, indicating that the excess risk is not due to ethnically differential genetic pre-disposition but rather due to modifiable factors.
Rapid Evidence Review of Community Engagement and Resources in the UK during the COVID-19 Pandemic: How Can Community Assets Redress Health Inequities?
Authors: Mughal Rabya , Thomson Linda J. M. , Daykin Norma , Chatterjee Helen J.
Published: March 2022

Community engagement, such as participating in arts, nature or leisurely activities, is positively associated with psychological and physiological wellbeing. Community-based engagement during the COVID-19 pandemic facilitated informal and local mutual aid between individuals. This rapid evidence review assesses the emergence of community-based arts, nature, music, theatre and other types of cultural engagement amongst UK communities in response to the COVID-19 pandemic. Here, we focus on all community engagement with a sub-focus on provisions accessed by and targeted towards vulnerable groups. Two hundred and fifty-six resources were included that had been created between February 2020 and January 2021. Resources were identified through Google Scholar, PubMed, Web of Science, MedRXic, PsycharXiv and searches for grey literature and items in the public domain. The majority reported services that had been adapted to become online, telephone-based or delivered at a distance from doorsteps. Several quality assessment frameworks were used to evaluate the quality of data. Whilst a number of peer-reviewed, grey literature and public domain articles were identified, less than half of the identified literature met quality thresholds. The pace of the response to the pandemic may have meant that robust evaluation procedures were not always in place.
A Blockchain Secured Pharmaceutical Distribution System to Fight Counterfeiting
Authors: Zoughalian Kavyan , Marchang Jims , Ghita Bogdan
Published: March 2022

Counterfeiting drugs has been a global concern for years. Considering the lack of transparency within the current pharmaceutical distribution system, research has shown that blockchain technology is a promising solution for an improved supply chain system. This study aims to explore the current solution proposals for distribution systems using blockchain technology. Based on a literature review on currently proposed solutions, it is identified that the secrecy of the data within the system and nodes’ reputation in decision making has not been considered. The proposed prototype uses a zero-knowledge proof protocol to ensure the integrity of the distributed data. It uses the Markov model to track each node’s ‘reputation score’ based on their interactions to predict the reliability of the nodes in consensus decision making. Analysis of the prototype demonstrates a reliable method in decision making, which concludes with overall improvements in the system’s confidentiality, integrity, and availability. The result indicates that the decision protocol must be significantly considered in a reliable distribution system. It is recommended that the pharmaceutical distribution systems adopt a relevant protocol to design their blockchain solution. Continuous research is required further to increase performance and reliability within blockchain distribution systems.
Depression Symptoms among Family Members of Nyaope Users in the City of Tshwane, South Africa
Authors: Madiga Maphuti Carol , Mokwena Kebogile
Published: March 2022

Substance abuse brings major negative social and health impacts in South Africa. Nyaope, a cocktail drug commonly used in the Tshwane townships, has been well documented to be highly addictive and very difficult to quit. The resultant difficulties include financial, social, and mental, specifically depression and anxiety. This study aims to quantify the depression levels among family members with nyaope users in Tshwane, South Africa. The study used a quantitative cross-sectional design to collect data in nine Tshwane communities. The patient health questionnaire-9 (PHQ-9) screening tool and demographic data collection questionnaires were used to collect data from a sample of 390 male and female family members who included mothers, fathers, grandparents, aunts, uncles, partners, and siblings of nyaope users, and who share a home with them. The ages of the participants ranged from 18 to 87 years, with a mean age of 47 years, while the ages of the nyaope users ranged from 17 to 55 years, with a mean age of 30 years. Depression scores ranged from 0 to 27 with a mean of 7. Depressive symptoms, as measured by the PHQ-9 scores of 5 and above, were reported by 49% of the sample. The levels of depression symptoms ranged from mild to severe, and the severity was higher among female, unemployed, and single participants. As with many others, these participants were not diagnosed and therefore were not treated. The study, therefore, identified that living with nyaope users is associated with the development of different levels of depression symptoms and has resulted in reduced quality of life among family members. The study recommends interventions that intentionally focus on families who live with individuals who are addicted to nyaope. Those interventions should focus on screening and treatment of depression and other mental disorders.
Value-Based Pricing and Budget Impact Analysis for Multi-Indication Drugs: A Case Study of Immunotherapies
Authors: Ha So-Young , Kang Dong-Won , Jung Hye-In , Lee Eui-Kyung , Park Mi-Hai
Published: March 2022

We aimed to calculate the value-based price of each indication and compare the drug price and budget impact among value-based pricing (VBP) scenarios, using immunotherapy as a case. Atezolizumab, nivolumab, and pembrolizumab prices were estimated for VBP scenarios, namely indication value-based pricing (IBP), IBP with refund, and weighted-average pricing (WAP). To estimate the value-based price of each indication, cost-effectiveness analyses were conducted by setting the incremental cost-effectiveness ratio of the first reimbursed indication to the threshold. The budget impact for each scenario was compared with that of the pricing system in Korea (which has a 4.75% price reduction). The value-based prices of non-reimbursed indications were lower for atezolizumab and higher for nivolumab than those for the reimbursed indication. The drug price fluctuations were the largest in IBP, varying between 28.56–328.81% of the current list price. The net price of the non-reimbursed indications decreased from 0% to 71.44% in IBP with refund, and the budget impact was the lowest among VBPs. Although the fluctuation in the budget impact in WAP was smaller than IBP, higher drug prices were identified for low-value indications. In conclusion, IBP with refund is a viable method for multi-indication drugs, because it has minimal drug price and budget impact changes.
Trend and Seasonality of Diabetic Foot Amputation in South Korea: A Population-Based Nationwide Study
Authors: Chung Hyung-Jin , Chun Dong-Il , Kang Eun Myeong , Kim Keonwoo , Lee Jinyoung , Jeon Ye Jin , Cho Jaeho , Won Sungho , Yi Young
Published: March 2022

The number of lower extremity amputations in diabetic foot patients in Korea is increasing annually. In this nationwide population-based retrospective study, we investigated the data of 420,096 diabetes mellitus patients aged ≥18 years using the Korean Health Insurance Review and Assessment Service claim database. We aimed to study the seasonal and monthly trends in diabetic foot amputations in Korea. After applying the inclusion criteria, 8156 amputation cases were included. The analysis showed an increasing trend in monthly amputation cases. In terms of seasonality, the monthly frequency of amputation was commonly observed to be lower in February and September every year. Diabetic foot amputations frequently occurred in March, July, and November. There was no difference between the amputation frequency and mean temperature/humidity. This study is meaningful as it is the first nationwide study in Korea to analyze the seasonal and monthly trends in diabetic foot amputation in relation to climatic factors. In conclusion, we recognize an increased frequency of amputation in March, July, and November and recommend intensive educational program on foot care for all diabetes patients and their caregivers. This could improve wound management and amputation prevention guidelines for diabetic foot patients in the Far East with information on dealing with various seasonal changes.
Tolerance of Human Fibroblasts to Benfo-Oxythiamine In Vitro
Authors: Yan Ming , Smeets Ralf , Gosau Martin , Vollkommer Tobias , Fuest Sandra , Stetzer Eva , Kluwe Lan , Coy Johannes , Burg Simon
Published: March 2022

Objectives: To explore the potential application of B-OT in the aspiration tract. Materials and Methods: We conceived and optimized an in vitro model simulating the mouth-washing process to assess tolerance to B-OT on primary human gingival fibroblasts. Cells derived from 4 unrelated donors were flushed with medium containing drugs of various concentration for one minute twice daily for 3 days. Results: No effect was seen on the cells up to 1000 µM B-OT. In addition, we treated the cells with B-OT permanently in medium, corresponding to a systemic treatment. No effect was seen by 10 µM B-OT and only a slight reduction (approximately 10%) was seen by 100 µM B-OT. Conclusions: Our results suggest good tolerance of oral cells for B-OT, favoring the further development of this antiviral reagent as a mouth-washing solution and nasal spray.
Food Supply Impacts and Solutions Associated with the COVID-19 Pandemic: A Regional Australian Case Study
Authors: Godrich Stephanie Louise , Macau Flavio , Kent Katherine , Lo Johnny , Devine Amanda
Published: March 2022

This study aimed to explore how food supply chains were impacted by COVID-19 and identify how the region could be better prepared for future crises. An online survey was completed by 107 consumers. In-depth interviews were conducted with 27 food supply stakeholders working in food production, distribution, retail, hospitality, institutions (i.e., childcare), logistics/freight and local government. Pre-COVID-19, farmer-direct distribution options and hospitality businesses comprised a substantial proportion of local food producer businesses. During the COVID-19 pandemic, consumers favoured local food supply options, farmers collaborated, and produce usually destined for export was redirected into local markets. Critical food supply actions included keeping borders open to food freight, enhancing social capital through real-time business communication, and business flexibility. Solutions included business adaptation, for example, farmers selling produce boxes and hospitality businesses selling excess stock, COVID-safe delivery, and collaboration through digital networks. To better prepare the region for future crises, actions to support communities could include a community approach to agriculture, increasing food supply diversity, facilitating transport to aid food distribution and purchasing, and more effective messaging to discourage panic buying. Actions to support retailers could include increasing access to wholesalers through online platforms. Actions to support producers could include improving infrastructure, such as more regional distribution facilities.
Chronic Obstructive Pulmonary Disease Effect of Nonapnea Sleep Disorder on the Risk of Obesity: A Nationwide Population-Based Case–Control Study
Authors: Yu Pi-Ching , Chung Ren-Jei , Huang Yao-Ching , Huang Shi-Hao , Wang Bing-Long , Chien Wu-Chien , Chung Chi-Hsiang , Sun Chien-An , Yang Sung-Sen , Wu Gwo-Jang
Published: March 2022

Objectives: To investigate whether chronic obstructive pulmonary disease (COPD) affects nonapnea sleep disorder (NASD) on the risk of obesity. Materials and Methods: From 1 January 2000 to 31 December 2015, a total of 24,363 patients with obesity from the 2005 Longitudinal Health Insurance Database were identified; 97,452 patients without obesity were also identified from the same database. Multiple logistic regression was used to analyze the previous exposure risk of patients with obesity and NASD. A p value of <0.05 was considered significant. Results: The risk of developing obesity in patients with COPD is 3.05 times higher than that in patients without COPD. Patients with COPD with NASD had a 1.606-fold higher risk of developing obesity than those without NASD. Patients with obesity were more likely to be exposed to NASD than did those without obesity (adjusted odds ratio, 1.693; 95% confidence interval, 1.575–1.821, p < 0.001). Furthermore, the closeness of the exposure period to the index time was positively associated with the severity of obesity, with a dose–response effect. The exposure duration of NASD in patients with obesity was 1.693 times than that in those without obesity. Longer exposure durations were associated with more severe obesity, also with a dose–response effect. Conclusions: The COPD effect of NASD increases the subsequent risk of obesity, and the risk of obesity was determined to be significantly higher in patients with NASD in this case–control study. Longer exposure to NASD was associated with a higher likelihood of obesity, also with a dose–response effect.
Savings and Losses of Scarce Virtual Water in the International Trade of Wheat, Maize, and Rice
Authors: Wu Hanfei , Jin Ruochen , Liu Ao , Jiang Shiyun , Chai Li
Published: March 2022

The international cereal trade can mitigate global water stress by saving virtual scarce water (VSW). Based on bilateral trade data, this study assessed VSW savings and losses in the international trade of three major cereals (i.e., wheat, maize, and rice) from 2008 to 2017 by incorporating the water stress index (WSI) into a virtual water assessment. We found that the trade in wheat and maize saved a significant amount of VSW, while the rice trade led to increasingly severe losses of VSW. This study identified the top trades of VSW savings and losses for each cereal. Wheat and maize were primarily exported from the countries that are relatively abundant in water resources (e.g., United States, Brazil, Argentina, Russia) to water-scarce countries (e.g., Mexico and Egypt), whereas rice was exported mainly from India and Pakistan, two of the most water-stressed countries. We suggest that policy makers consider VSW savings and losses when making cereal trading decisions to alleviate global water stress.
Changes in the Mental Health of Children and Adolescents during the COVID-19 Lockdown: Associated Factors and Life Conditions
Authors: Bosch Rosa , Pagerols Mireia , Prat Raquel , Español-Martín Gemma , Rivas Cristina , Dolz Montserrat , Haro Josep Maria , Ramos-Quiroga Josep Antoni , Ribasés Marta , Casas Miquel
Published: March 2022

This study investigated the psychological impact of the coronavirus disease 2019 (COVID-19) among youth by analyzing their emotional/behavioral problems before and during the long-lasting lockdown in Spain. For that purpose, 699 parents with children aged 6–17 and 552 adolescents aged 12–17, who completed the parent and adolescent version of the Strengths and Difficulties Questionnaire at the beginning of 2019, responded to a survey from 26 May to 15 June 2020 that assessed psychological well-being and life conditions during quarantine (i.e., sociodemographic characteristics, situation before the lockdown, physical environment and accompaniment during the lockdown, COVID-related variables). According to both parent- and self-reports, children and youth experienced a significant worsening in emotional symptoms, conduct problems, hyperactivity/inattention, peer problems, and total difficulties subscales. Findings also suggested that impairment was mainly associated with variables related to the child’s situation prior to home quarantine, the quality and quantity of the child’s social networks during the lockdown, the daily routines the child followed, the concerns the child had about health, and the presence of economic and learning problems caused by the COVID-19. Thus, the present investigation emphasizes the need for carefully monitoring the mental health of younger people, provides guidance for the development of interventions that mitigate some of the psychological difficulties faced in a situation of confinement, and highlights the importance of paying special attention to high-risk groups.
Associations between Leisure Preferences, Mindfulness, Psychological Capital, and Life Satisfaction
Authors: Dirzyte Aiste , Patapas Aleksandras , Perminas Aidas
Published: March 2022

This study intended to explore which leisure preferences contribute to mindfulness, psychological capital, and life satisfaction and assess whether mindfulness, psychological capital, and life satisfaction are associated with different leisure preferences. This study applied the Satisfaction with Life Scale (SWLS), the Psychological Capital Questionnaire (PCQ-12), the Mindful Attention Awareness Scale (MAAS), and the instrument to evaluate the prevalence of leisure preferences. A sample consisted of 586 participants, 104 males and 478 females. The mean age of participants was 42.06, SD = 13.29. The results show that respondents who did not spend free time watching television scored higher on life satisfaction, mindfulness, and psychological capital. Participants who preferred attending events scored higher on life satisfaction and psychological capital. Participants who preferred spending time with family as a leisure preference scored significantly higher on life satisfaction, mindfulness, and psychological capital, including PsyCap overall, PsyCap work, PsyCap relationship, and PsyCap health. The findings also reveal that time spent with family is significantly associated with life satisfaction. Besides, males’ life satisfaction was significantly associated with time spent in nature, while females’ satisfaction was associated with spending time with family and participating in events. Males’ mindfulness was significantly associated with book reading, and females’ mindfulness was associated with not watching television. Males’ psychological capital was significantly associated with spending time with family and book reading, and females’ psychological capital was associated with not watching television but spending time with family, participating in events, and spending time in nature. The findings also showed that mindfulness mediated the link between watching television and life satisfaction, and psychological capital mediated links between spending time with family, participating in events, and life satisfaction. The findings demonstrate that life satisfaction is also significantly associated with spending time with family as a leisure preference. This study also revealed a significant negative association between age and spending time with friends or family, evidencing the possible loneliness of elderly respondents. Due to limitations of this study, including sample size and characteristics, cultural context, and research design, the research findings would preferably be regarded thoughtfully.
OSM Science—The Academic Study of the OpenStreetMap Project, Data, Contributors, Community, and Applications
Authors: Grinberger A. Yair , Minghini Marco , Juhász Levente , Yeboah Godwin , Mooney Peter
Published: March 2022

This paper is an Editorial for the Special Issue titled “OpenStreetMap as a multidisciplinary nexus: perspectives, practices and procedures”. The Special Issue is largely based on the talks presented in the 2019 and 2020 editions of the Academic Track at the State of the Map conferences. As such, it represents the most pressing and relevant issues and topics considered by the academic community in relation to OpenStreetMap (OSM)—a global project and community aimed to create and maintain a free and editable database and map of the world. In this Editorial, we survey the papers included in the Special Issue, grouping them into three research perspectives: applications of OSM for studies within other disciplines, OSM data quality, and dynamics in OSM. This survey reveals that these perspectives, while being distinct, are also interrelated. This calls for the formalization of an ‘OSM science’ that will provide the conceptual grounds to advance the scientific study of OSM, not as a set of individualized efforts but as a unified approach.
Exercise Ameliorates Atherosclerosis via Up-Regulating Serum β-Hydroxybutyrate Levels
Authors: Xu Zhou , Zhang Mingyue , Li Xinran , Wang Yong , Du Ronghui
Published: March 2022

Atherosclerosis, accompanied by inflammation and metabolic disorders, is the primary cause of clinical cardiovascular death. In recent years, unhealthy lifestyles (e.g., sedentary lifestyles) have contributed to a worldwide epidemic of atherosclerosis. Exercise is a known treatment of atherosclerosis, but the precise mechanisms are still unknown. Here, we show that 12 weeks of regular exercise training on a treadmill significantly decreased lipid accumulation and foam cell formation in ApoE−/− mice fed with a Western diet, which plays a critical role in the process of atherosclerosis. This was associated with an increase in β-hydroxybutyric acid (BHB) levels in the serum. We provide evidence that BHB treatment in vivo or in vitro increases the protein levels of cholesterol transporters, including ABCA1, ABCG1, and SR-BI, and is capable of reducing lipid accumulation. It also ameliorated autophagy in macrophages and atherosclerosis plaques, which play an important role in the step of cholesterol efflux. Altogether, an increase in serum BHB levels after regular exercise is an important mechanism of exercise inhibiting the development of atherosclerosis. This provides a novel treatment for atherosclerotic patients who are unable to undertake regular exercise for whatever reason. They will gain a benefit from receiving additional BHB.