bluuebunny/crossref_metadata_2025 huggingface dataset:
Pengaruh Terapi Token Ekonomi Terhadap Kecemasan Anak Usia Prasekolah Yang Mengalami Hospitalisasi
Authors: Ramaita Ramaita , Putri Sri Burhani
Published: January 2020

Kecemasan adalah kondisi yang sering ditemukan pada anak prasekolah yang mengalami hospitalisasi. Hospitalisasi adalah suatu keadaan yang mengharuskan anak dirawat dirumah sakit untuk mendapatkan pengobatan. Hampir dalam setiap tahap perkembangan usia anak, kecemasan dan ketakutan akan penanganan medis masih menjadi masalah besar dalam pelayanan keperawatan. salah satu metode yang dapat digunakan untuk menurunkan kecemasan anak adalah terapi token ekonomi. Token ekonomi adalah terapi untuk mengubah perilaku dengan menggunakan pemberian reinforcement dan token. Penelitian ini bertujuan untuk mengetahui pengaruh terapi token ekonomi untuk mengurangi tingkat kecemasan anak prasekolah. Penelitian ini dilakukan di RSUP DR. M.Djamil Padang selama 2 bulan mulai dari tanggal 2 Juli s/d 4 September 2019. Penelitian ini menggunakan desain penelitian quasi experimental design dengan pendekatan pre-post test group design with control group. Populasi dalam penelitian ini adalah seluruh anak prasekolah yang mengalami hospitalisasi. Pengambilan sampel dilakukan dengan teknik purposive sampling dimana 68 responden dibagi kedalam kelompok intervensi (n=34) dan kelompok kontrol (n=34). Analisis menggunakan uji Independent Sample T-Test. Hasil penelitian menunjukkan bahwa ada perbedaan tingkat kecemasan anak prasekolah sebelum dan sesudah penerapan token ekonomi pada kelompok intervensi dibanding dengan kelompok kontrol dengan p value = 0.000. Terapi token ekonomi mempunyai pengaruh positif untuk menurunkan tingkat kecemasan pada anak prasekolah yang mengalami hospitalisasi. Penerapan token ekonomi ini direkomendasikan untuk mengatasi kecemasan pada anak usia prasekolah pada pelayanan kesehatan dirumah sakit dan komunitas.
Pengaruh Hipnoterapi Terhadap Kemampuan Menelan Pada Pasien Stroke Iskemik
Authors: Sari Lisa Mustika , Rafdinal Sabri
Published: January 2020

Menelan merupakan proses yang kompleks karena melibatkan beberapa fungsi saraf kranial. Gangguan menelan disebabkan oleh paresis atau kerusakann nervus fasialis, trigeminus, hipoglasus, glossoparingeus dan vagus. Fungi saraf kranial tersebut berperan dalam proses mengunyah, menelan dan bicara. Adanya gangguan pada salah  satu saraf kranial tersebut maka akan berdampak pada keadekuatan fungsi menelan, mengunyah dan fungsi bicara. Berdasarkan hasil observasi pada pasien stroke iskemik di ruang neorologi RSUD. DR. M.A Hanafiah SM Batusangkar sebagian besar pasien yang dirawat mengalami gangguan menelan. Tujuan dari penelitian ini adalah untuk mengetahui pengaruh hipnoterapi terhadap kemampuan menelan pada pasien stroke iskemik di ruang neorologi RSUD.DR.M.AHanafiah SM Batusangkar tahun 2019. Metoda penelitian adalah Quasy Experimental Designs dengan pendekatan one group pretest-posttest design. Teknik pengambilan sampel adalah simple random sampling, dimana sampel yang diteliti sebanyak 10 orang responden pasien stroke yang mengalami gangguan menelan. Data di analisis dengan uji statistik t-test independent. Hasil penelitian ini didapatkan rerata kemampuan menelan sebelum dilakukan hipnoterapi sebanyak 5,9 dan rerata kemampuan menelan sesudah dilakukan hipnoterapi sebanyak 7,7. Hasil uji statistik didapatkan p value 0,000 artinya ada pengaruh hipnoterapi terhadap kemampuan menelan pada pasien stroke iskemik di ruang neorologi RSUD. DR.  M.A Hanafiah SM Batusangkar Tahun 2019. Diharapakan  dapat menjadi intervensi mandiri bagi perawat sebagai tindakan nonfarmakologis pada masalah gangguan menelan sehingga klien dapat mencapai kesehatan yang lebih optimal.
AKKOYUNLU SARAYINDA BİR BEGÜM YADA MEHD-İ ULYÂ: SELÇUKŞAH BEGÜM
Authors: ATICI ARAYANCAN Ayse
Published: January 2020

Türk tarihinin birçok
döneminde güç, iktidar, hırs üçgeninde hatunlar, begümler, kadın sultanlar
bazen hükümdarın yanında, taht kavgalarında, bazen de diplomatik siyasi
krizler, divan ve hayır işlerinde aktif roller üstlenmişlerdir. Bu kadınlardan
biri de sultan eşi ve annesi olarak Begüm, Mehd-i Ulya gibi adlandırmalar ile
tarih kayıtlarında adı geçen Selçukşah Begüm’dür.  XV.Yüzyıl İran ve Yakın Doğu tarihinde
yaptıkları ile tarihin seyrini değiştirmeyi başarmış gerçek kadın figürlerden
biridir. Siyasi olarak istikrarın sağlanamadığı, devlet teşkilatının ve yönetim
biçiminin oturtulmaya çalışıldığı bir dönemde önce sultan eşi daha sonra sultan
annesi olarak Akkoyunlu yönetiminin merkezinde bulunmayı başarmıştır. Akkoyunlu
sarayında yaklaşık 35 yıldan fazla bulunan Selçukşah Begüm, zaman zaman aldığı
kararlar, uygulamalar ve entrikalarından dolayı bazı saray çevreleri tarafından
istenmemiş hatta kaynaklarda musibet, felaket, sırtlan olarak adlandırılmıştır.
Ancak aşiret reisleri başta olmak üzere bazı kesimler tarafından ise büyük
itibar ve saygı görmüştür.

Bu makalede, özelde
Akkoyunlu Selçukşah Begüm’ün Akkoyunlu devlet yönetimindeki nüfuzu, eşi Uzun
Hasan ve oğulları Halil ve Yakûb üzerindeki etkisi, saraydaki entrikaları,
hırsı, şaibeli ölümü, hayırseverliği, tasavvufa olan yakınlığı ele alınırken,
genelde ise Akkoyunlu saray
America Still Held Hostage: The Hostage Crisis Generation and Public Opinion about Iran Deal
Authors: Koruzhde Mazaher , Popova Valeriia
Published: January 2020

The hostage crisis of 1979 was a defining moment in the history of US-Iran relationship that left a lasting impact on the generation of the Americans who witnessed it and deeply affected their attitudes toward Iran and Iran-related policies. In this paper, we use a case study of the Iran nuclear deal to put this idea to the test. We hypothesize that the hostage crisis generation is less likely to support the Iran nuclear deal than the post-hostage crisis generation. Using data from the 2015 Chicago Council Survey of American Public Opinion and U.S. Foreign Policy, we conduct a formal statistical analysis. The results of our OLS regression analysis show that there is a statistically significant difference between foreign policy attitudes of the two generations, irrespective of partisanship and ideology that are usually considered the main determinants of public opinion on foreign policy.
Image Completion with Large or Edge-Missing Areas
Authors: Ji Jianjian , Yang Gang
Published: January 2020

Existing image completion methods are mostly based on missing regions that are small or located in the middle of the images. When regions to be completed are large or near the edge of the images, due to the lack of context information, the completion results tend to be blurred or distorted, and there will be a large blank area in the final results. In addition, the unstable training of the generative adversarial network is also prone to cause pseudo-color in the completion results. Aiming at the two above-mentioned problems, a method of image completion with large or edge-missing areas is proposed; also, the network structures have been improved. On the one hand, it overcomes the problem of lacking context information, which thereby ensures the reality of generated texture details; on the other hand, it suppresses the generation of pseudo-color, which guarantees the consistency of the whole image both in vision and content. The experimental results show that the proposed method achieves better completion results in completing large or edge-missing areas.
A Comparative Study of Four Metaheuristic Algorithms, AMOSA, MOABC, MSPSO, and NSGA-II for Evacuation Planning
Authors: Niyomubyeyi Olive , Sicuaio Tome Eduardo , Díaz González José Ignacio , Pilesjö Petter , Mansourian Ali
Published: January 2020

Evacuation planning is an important activity in disaster management to reduce the effects of disasters on urban communities. It is regarded as a multi-objective optimization problem that involves conflicting spatial objectives and constraints in a decision-making process. Such problems are difficult to solve by traditional methods. However, metaheuristics methods have been shown to be proper solutions. Well-known classical metaheuristic algorithms—such as simulated annealing (SA), artificial bee colony (ABC), standard particle swarm optimization (SPSO), genetic algorithm (GA), and multi-objective versions of them—have been used in the spatial optimization domain. However, few types of research have applied these classical methods, and their performance has not always been well evaluated, specifically not on evacuation planning problems. This research applies the multi-objective versions of four classical metaheuristic algorithms (AMOSA, MOABC, NSGA-II, and MSPSO) on an urban evacuation problem in Rwanda in order to compare the performances of the four algorithms. The performances of the algorithms have been evaluated based on the effectiveness, efficiency, repeatability, and computational time of each algorithm. The results showed that in terms of effectiveness, AMOSA and MOABC achieve good quality solutions that satisfy the objective functions. NSGA-II and MSPSO showed third and fourth-best effectiveness. For efficiency, NSGA-II is the fastest algorithm in terms of execution time and convergence speed followed by AMOSA, MOABC, and MSPSO. AMOSA, MOABC, and MSPSO showed a high level of repeatability compared to NSGA-II. It seems that by modifying MOABC and increasing its effectiveness, it could be a proper algorithm for evacuation planning.
Morphometric Evaluation of Spermatogenic Cells and Seminiferous Tubules and Exploration of Luteinizing Hormone Beta Polypeptide in Testis of Datong Yak
Authors: Kalwar Qudratullah , Chu Min , Ahmad Anum Ali , Ding Xuezhi , Wu Xiaoyun , Bao Pengjia , Yan Ping
Published: January 2020

Histological examination of testes is essential for understanding infertility, sex development, and growth. Therefore, to understand the histomorphology of testes at different developmental stages, we performed hematoxylin and eosin staining of Yak testis. Our results revealed that the diameters of spermatogenic cells and their nuclei were significantly larger (p < 0.05) in the testis at six years compared to at six and 18 months. No significant difference was noted between 30 months and six years. The study was designed to compare the expression profile of LHB in Datong yak. The expression pattern of LHB was explored using quantitative PCR, semi-quantitative PCR, molecular bioinformatic, and Western blot analysis. Our observations indicated that expression of LHB was significantly higher (p < 0.05) in the testis of Datong yak. Western blotting indicated that the molecular mass of LHB protein was 16 kDa in yak. The protein encoded by yak LHB included conserved cysteine-knot domain regions. The high expression of LHB in testis indicated that LHB may be vital for the development of male gonads and the fertility of Datong yak.
Effect of Yeast Culture (Saccharomyces cerevisiae) on Broilers: A Preliminary Study on the Effective Components of Yeast Culture
Authors: Sun Zhe , Wang Tao , Demelash Natnael , Zheng Sen , Zhao Wei , Chen Xue , Zhen Yuguo , Qin Guixin
Published: January 2020

This study was aimed at determining the effective ingredients of yeast culture (YC) for animal breeding. First, the contents of YCs obtained from various fermentation times were detected using gas-chromatography. A total of 85 compounds were identified. Next, 336 Arbor Acres (AA) broilers were randomly divided into seven experimental groups and fed a basal diet, diets supplemented with YCs obtained at various fermentation times, or SZ1 (a commercial YC product). A significant increase in body weight gain (BWG) and a significant decrease in feed conversion ratio (FCR) of AA broiler chicks were observed with YC supplementation. Additionally, most of blood and immunological indices were improved with YC supplementation. According to the production performance and the results of multivariate analysis, glycine, fructose, inositol, galactose, and sucrose were found as the potential effective compounds of YC and were involved in metabolic pathways including glycine, serine, and threonine metabolism. Supplementation with diets based on combinations of effective compounds improved weight gain, feed efficiency, serum immunoglobulin A, and immunoglobulin G, but decreased blood urea concentration. These findings suggest YCs as effective and harmless feed additives with improved nutritional properties for broiler chicks.
The Simultaneous Administration of a Probiotic or Prebiotic with Live Salmonella Vaccine Improves Growth Performance and Reduces Fecal Shedding of the Bacterium in Salmonella-Challenged Broilers
Authors: El-Shall Nahed A. , Awad Ashraf M. , El-Hack Mohamed E. Abd , Naiel Mohammed A. E. , Othman Sarah I. , Allam Ahmed A. , Sedeik Mahmoud E.
Published: January 2020

Salmonellosis is one of the most important bacterial diseases in poultry, causing heavy economic losses, increased mortality and reduced production. The aim of this study was the comparative efficacy of a commercial probiotic and/or prebiotic with a live attenuated Salmonella Enteritidis (SE) vaccine on the protection of broiler chickens from SE challenge. The efficacy of probiotic or prebiotic products, as well as a live Salmonella Enteritidis (SE) vaccine at the 7th day of age, administered via drinking water, were evaluated for clinical protection and effects on growth performance of broiler chickens experimentally challenged with SE at the 28th day of age. The use of probiotic or prebiotic simultaneously with the live Salmonella vaccine can diminish the negative effect of live vaccine growth performance, reducing mortality rate, fecal shedding, and re-isolation of SE from liver, spleen, heart and cecum. The use of probiotic or prebiotic simultaneously with the application of the live Salmonella vaccine is a good practice to diminish the negative effect of the harmful bacteria and improve the growth performance of broilers. Thus, further studies may be carried out with layers and breeders.
From Mice to Monkeys? Beyond Orthodox Approaches to the Ethics of Animal Model Choice
Authors: Walker Rebecca L. , Eggel Matthias
Published: January 2020

Recent developments in genome editing tools, along with limits in the translational potential of rodent models of human disease, have spurred renewed biomedical research interest in large mammals like nonhuman primates, pigs, and dogs. Such scientific developments raise ethical issues about the use of these animals in comparison with smaller mammals, such as mice and rats. To examine these ethical questions, we first consider standard (or “orthodox”) approaches, including ethics oversight within biomedical research communities, and critical theoretical reflections on animal research, including rights-based and utilitarian approaches. We argue that oversight of biomedical research offers guidance on the profession’s permitted uses of animals within a research setting and orthodox approaches to animal ethics questions when and whether animals should be used in biomedicine; however, neither approach sufficiently investigates the nuances of ethical practices within the research setting. To fill this lacuna, we consider a virtue ethical approach to the use of specific animal models in biomedicine. From this perspective, we argued that limitations on flourishing for large mammals in a research setting, as well as potential human-animal bonds, are two sources of likely ethical tensions in animal care and use in the context of larger mammals.
Clonal Diversity, Biofilm Formation, and Antimicrobial Resistance among Stenotrophomonas maltophilia Strains from Cystic Fibrosis and Non-Cystic Fibrosis Patients
Authors: Pompilio Arianna , Savini Vincenzo , Fiscarelli Ersilia , Gherardi Giovanni , Di Bonaventura Giovanni
Published: January 2020

The intrinsic antibiotic resistance of Stenotrophomonas maltophilia, along with its ability to form biofilm both on abiotic surfaces and host tissues, dramatically affects the efficacy of the antibiotic therapy. In this work, 85 S. maltophilia strains isolated in several hospital of central Italy and from several clinical settings were evaluated for their genetic relatedness (by pulsed-field gel electrophoresis, PFGE), biofilm formation (by microtiter plate assay), and planktonic antibiotic resistance (by Kirby–Bauer disk diffusion technique). The S. maltophilia population showed a high genetic heterogeneity: 64 different PFGE types were identified, equally distributed in cystic fibrosis (CF) and non-CF strains, and some consisted of multiple strains. Most of the strains (88.2%) were able to form biofilm, although non-CF strains were significantly more efficient than CF strains. CF strains produced lower biofilm amounts than non-CF strains, both those from respiratory tracts and blood. Non-CF PFGE types 3 and 27 consisted of strong-producers only. Cotrimoxazole and levofloxacin were the most effective antibiotics, being active respectively against 81.2% and 72.9% of strains. CF strains were significantly more resistant to piperacillin/tazobactam compared to non-CF strains (90% versus 53.3%), regardless of sample type. Among respiratory strains, cotrimoxazole was more active against non-CF than CF strains (susceptibility rates: 86.7% versus 75%). The multidrug resistant phenotype was significantly more prevalent in CF than non-CF strains (90% versus 66.7%). Overall, the multidrug-resistance level was negatively associated with efficiency in biofilm formation. Our results showed, for the first time, that in S. maltophilia both classical planktonic drug resistance and the ability of biofilm formation might favor its dissemination in the hospital setting. Biofilm formation might in fact act as a survival mechanism for susceptible bacteria, suggesting that clinical isolates should be routinely assayed for biofilm formation in diagnostic laboratories.
Looking beyond Typical Treatments for Atypical Mycobacteria
Authors: Bento Clara M. , Gomes Maria Salomé , Silva Tânia
Published: January 2020

The genus Mycobacterium comprises not only the deadliest of bacterial pathogens, Mycobacterium tuberculosis, but several other pathogenic species, including M. avium and M. abscessus. The incidence of infections caused by atypical or nontuberculous mycobacteria (NTM) has been steadily increasing, and is associated with a panoply of diseases, including pulmonary, soft-tissue, or disseminated infections. The treatment for NTM disease is particularly challenging, due to its long duration, to variability in bacterial susceptibility profiles, and to the lack of evidence-based guidelines. Treatment usually consists of a combination of at least three drugs taken from months to years, often leading to severe secondary effects and a high chance of relapse. Therefore, new treatment approaches are clearly needed. In this review, we identify the main limitations of current treatments and discuss different alternatives that have been put forward in recent years, with an emphasis on less conventional therapeutics, such as antimicrobial peptides, bacteriophages, iron chelators, or host-directed therapies. We also review new forms of the use of old drugs, including the repurposing of non-antibacterial molecules and the incorporation of antimicrobials into ionic liquids. We aim to stimulate advancements in testing these therapies in relevant models, in order to provide clinicians and patients with useful new tools with which to treat these devastating diseases.
Statistical Properties and Configurational Entropy of a Two-Dimensional Néel Magnetic Skyrmions Population
Authors: Zivieri Roberto
Published: January 2020

The study of the thermodynamic properties of topological defects is important not only for understanding their magnetic properties but also for suggesting novel applications. In this paper, the statistical and statistical thermodynamic properties of a population of Néel magnetic skyrmion diameters hosted in an ultrathin cylindrical dot is determined within a two-dimensional analytical approach. The statistical properties such as the skyrmion size are calculated in the region of skyrmion metastability and are compared with the ones obtained using a recent three-dimensional analytical approach based on the analogy with the Maxwell–Boltzmann distribution of dilute gas molecules. The investigation of the statistical thermodynamic properties focus on the calculation of the configurational entropy at thermodynamic equilibrium determined in the continuous limit from the Boltzmann order function. While the statistical properties are quantitatively similar passing from the two-dimensional to the three-dimensional approach, the configurational entropy calculated from the two-dimensional skyrmions distribution is considerably lower than the one obtained from the three-dimensional skyrmions distribution. Because of the strong resemblance between the statistical configurational entropy and Jaynes’s information entropy, it is suggested to use magnetic skyrmions as temperature and external field dependent information entropy carriers for a future potential technological application in the field of low-dimensional magnetic systems and skyrmionics.
Prey of Pray: Allegorizing the Liturgical Practice
Authors: Orgad Zvi
Published: January 2020

Numerous images embedded in the painted decorations in early modern Central and Eastern European synagogues conveyed allegorical messages to the congregation. The symbolism was derived from biblical verses, stories, legends, and prayers, and sometimes different allegories were combined to develop coherent stories. In the present case study, which concerns a bird, seemingly a nocturnal raptor, depicted on the ceiling of the Unterlimpurg Synagogue, I explore the symbolism of this image in the contexts of liturgy, eschatology, and folklore. I undertake a comparative analysis of paintings in medieval and early modern illuminated manuscripts—both Christian and Jewish—and in synagogues in both Eastern and Central Europe. I argue that in some Hebrew illuminated manuscripts and synagogue paintings, nocturnal birds of prey may have been positive representations of the Jewish people, rather than simply a response to their negative image in Christian literature and art, but also a symbol of redemption. In the Unterlimpurg Synagogue, the night bird of prey, combined with other symbolic elements, represented a complex allegoric picture of redemption, possibly implying the image of King David and the kabbalistic nighttime prayer Tikkun Ḥaẓot. This case study demonstrates the way in which early modern synagogue painters created allegoric paintings that captured contemporary religious and mystical ideas and liturgical developments.
Influence of Thermal Effects on Qinghai-Tibet Plateau on Air Quality in Typical Regions of China in Winter
Authors: Li Yanjun , An Xingqin , Fan Guangzhou , Wang Chao , Zhao Yang , Li Jiangtao
Published: January 2020

In this paper, the National Centers for Environmental Prediction/National Center for Atmospheric Research (NCEP/NCAR) monthly average reanalysis data from 1954 to 2017, haze days observation data from 1954 to 2017, and PM2.5 daily average mass concentration data from 2013 to 2017 are collected and collated. Firstly, the atmospheric apparent heat source on the Qinghai-Tibet Plateau is estimated based on thermodynamic equations. The correlation between the atmospheric apparent heat source (Q1) on the Qinghai-Tibet Plateau and the air quality in China, especially in the five typical regions (Beijing-Tianjin-Hebei, Fen-Wei Plain, Yangtze River Delta, Pearl River Delta, and Sichuan-Chongqing regions) is analyzed and studied. Through comprehensive diagnosis and synthesis, the differences of the three-dimensional spatial distribution of the circulation field and temperature field (planes and sections) in China and the typical regions in the strong and weak years of the apparent heat source Q1 on the Qinghai-Tibet Plateau in winter are compared, and the different distribution characteristics of the climate circulation background causing the strong and weak years of Q1 on the Qinghai-Tibet Plateau and the influence mechanism on the air quality in different regions in China are discussed. The results show that the spatial distribution of correlation between Q1 on the Qinghai-Tibet Plateau and PM2.5 in December has a northeast-southwest boundary. There is a negative correlation in the southeast region of the boundary, with heavy pollution when the cold source is strong and light pollution when the cold source is weak, while there is a positive correlation in the northwest region of the boundary, with light pollution when the cold source is strong and heavy pollution when the cold source is weak. The Q1 on Qinghai-Tibet Plateau is negatively correlated with air pollution in Beijing-Tianjin-Hebei and Fen-Wei Plain located in the northwest region of the boundary but positively correlated with air pollution in the Yangtze River Delta, Pearl River Delta, and Sichuan-Chongqing regions located in the southeast region of the boundary. In the cold source strong year, the northerly winds are stronger in the middle and high latitudes, and there is an abnormal northerly downward flow in the southeast region, thus the pollution is aggravated by the suppression of convection–diffusion in a downward flow. However, abnormal updraft in the northwest region exists, reducing pollution. In the cold source weak year, the situation is just the opposite.
Refractive Indices of Biomass Burning Aerosols Obtained from African Biomass Fuels Using RDG Approximation
Authors: Sarpong Emmanuel , Smith Damon , Pokhrel Rudra , Fiddler Marc N. , Bililign Solomon
Published: January 2020

Biomass burning (BB) aerosols contribute to climate forcing, but much is still unknown about the extent of this forcing, owing partially to the high level of uncertainty regarding BB aerosol optical properties. A key optical parameter is the refractive index (RI), which influences the absorbing and scattering properties of aerosols. This quantity is not measured directly, but it is obtained by fitting the measured scattering cross section and extinction cross section to a theoretical model using the RI as a fitting parameter. We used the Rayleigh–Debye–Gans (RDG) approximation to retrieve the complex RI of freshly emitted BB aerosol from two fuels (eucalyptus and olive) from Africa in the spectral range of 500–580 nm. Experimental measurements were carried out using cavity ring-down spectroscopy to measure extinction over the range of wavelengths of 500–580 nm and nephelometry to measure scattering at three wavelengths of 450, 550, and 700 nm for size-selected BB aerosol particles. The fuels were combusted in a tube furnace at a temperature of 800 °C, which is representative of the flaming stage of burning. Filter samples were collected and imaged using tunneling electron microscopy to obtain information on the morphology and size of the particles, which was used in the RDG calculations. The mean radii of the monomers were 27.8 and 31.5 nm for the eucalyptus and the olive fuels, respectively. The components of the retrieved complex RI were in the range of 1.31 ≤ n ≤ 1.56 and 0.045 ≤ k ≤ 0.468. The real and complex parts of the RI increase with increasing particle mobility diameter. The real part of the RI is lower, and the imaginary part is higher than what was recommended in literature for black carbon generated by propane or field measurements from fires of mixed wood samples. Fuel dependent results from controlled laboratory experiments can be used in climate modeling efforts and to constrain field measurements from biomass burning.
Risk Factors for Recurrent Arterial Ischemic Stroke in Children and Young Adults
Authors: Sarecka-Hujar Beata , Kopyta Ilona
Published: January 2020

Arterial ischemic stroke (AIS) experienced at a young age is undoubtedly a serious medical problem. AIS very rarely occurs at a developmental age, whereas in young adults, it occurs with a higher frequency. The etiologic mechanisms of AIS occurring in childhood and adulthood differ. However, for both age populations, neurological consequences of AIS, including post-stroke seizures, motor disability, and recurrence of the disease, are connected to many years of care, rehabilitation, and treatment. Recurrent stroke was observed to increase the risk of patients’ mortality. One of the confirmed risk factors for recurrent stroke in children is the presence of vasculopathies, especially Moyamoya disease and syndrome, and focal cerebral arteriopathy of childhood (FCA). FCA causes a 5-fold increase in the risk of recurrent stroke in comparison with idiopathic AIS. In turn, young adults with recurrent stroke were found to more often suffer from hypertension, diabetes mellitus, or peripheral artery disease than young patients with first-ever stroke. Some reports also indicate relationships between specific genetic polymorphisms and AIS recurrence in both age groups. The aim of the present literature review was to discuss available data regarding the risk factors for recurrent AIS in children and young adults.
The Other-Race and Other-Species Effect during a Sex Categorization Task: An Eye Tracker Study
Authors: Bulut Merve , Erdeniz Burak
Published: January 2020

Sex categorization from faces is a crucial ability for humans and non-human primates for various social and cognitive processes. In the current study, we performed two eye tracking experiments to examine the gaze behavior of participants during a sex categorization task in which participants categorize face pictures from their own-race (Caucasian), other-race (Asian) and other-species (chimpanzee). In experiment 1, we presented the faces in an upright position to 16 participants, and found a strong other-race and other-species effect. In experiment 2, the same faces were shown to 24 naïve participants in an upside-down (inverted) position, which showed that, although the other-species effect was intact, other-race effect disappeared. Moreover, eye-tracking analysis revealed that in the upright position, the eye region was the first and most widely viewed area for all face categories. However, during upside-down viewing, participants’ attention directed more towards the eye region of the own-race and own-species faces, whereas the nose received more attention in other-race and other-species faces. Overall results suggest that other-race faces were processed less holistically compared to own-race faces and this could affect both participants’ behavioral performance and gaze behavior during sex categorization. Finally, gaze data suggests that the gaze of participants shifts from the eye to the nose region with decreased racial and species-based familiarity.
Motivational Conflicts and the Psychological Structure of Perfectionism in Patients with Anxiety Disorders and Patients with Essential Hypertension
Authors: Pervichko Elena I. , Babaev Yury A. , Podstreshnaya Anfisa K. , Zinchenko Yury P.
Published: January 2020

Many studies have shown connections between perfectionism, motivation, and anxiety disorders (AD), as well as essential hypertension (EH). The objective of this study is to examine the connections between motivation and the structure of perfectionism in AD patients and EH patients compared to healthy individuals. Projective and semi-projective tests (thematic apperception test (TAT) of Heckhausen, Multi-Motive Grid) were used to measure motivation, while a perfectionism questionnaire by Hewitt and Flett was used to determine perfectionism levels. The participants were 21 AD patients, 21 EH patients, and 33 healthy individuals. EH patients show higher level of other-oriented perfectionism, and AD patients demonstrate increased levels of self-oriented perfectionism compared to the healthy group. Both groups of patients are motivated by fear of failure rather than hope for success, and they also demonstrate an increased fear of rejection. AD patients have an increased fear of power of other people. In EH patients, the fear of power seems to play a significant role as it correlates with many other variables. In EH patients, the other-oriented perfectionism is connected to achievement motivation, whereas in AD patients the same is true for socially prescribed perfectionism. Overall, studying motivation and perfectionism in relation to various disorders seems to offer research prospects.
Protein Kinase B Inactivation Is Associated with Magnolol-Enhanced Therapeutic Efficacy of Sorafenib in Hepatocellular Carcinoma In Vitro and In Vivo
Authors: Chen Jiann-Hwa , Chiang I-Tsang , Hsu Fei-Ting
Published: January 2020

Although sorafenib, an oral multikinase inhibitor, was approved as a treatment drug of advance hepatocellular carcinoma (HCC), treatment efficacy still requires improvement. Searching for the adjuvant reagent for enhancing sorafenib efficacy remains as a critical issue. Sorafenib has been proved to suppress extracellular signal-regulated kinases (ERK) in HCC; however, protein kinase B (AKT) was not affected by it. Targeting AKT in combination with sorafenib could be an important breakthrough point of HCC treatment. Many herbal compounds and composite formulas have been shown to enhance anti-HCC activity of sorafenib. Magnolol is a bioactive compound extracted from the bark of the Magnolia officinalis and has been shown to induce apoptosis and inhibit cell invasion in HCC in vitro. However, whether magnolol sensitizes HCC to sorafenib is ambiguous. In this study, we indicated that magnolol significantly enhanced sorafenib-diminished tumor cell growth, expression of anti-apoptotic proteins, and migration/invasion ability compared to sorafenib alone. Magnolol significantly boosted sorafenib-induced extrinsic/intrinsic dependent apoptosis pathways in HCC. Notably sorafenib could not reduce protein level of AKT (Ser473), but expression of AKT (Ser473) was significantly decreased by magnolol or magnolol combined with sorafenib. LY294002 as specific AKT inhibitor was used to confirm that AKT inactivation may promote anticancer effect of sorafenib. Taken together, AKT inhibition is associated with magnolol-enhanced the therapeutic effect of sorafenib in HCC. We suggested magnolol as the potential adjuvant which may enhance therapeutic benefits of sorafenib in patients with HCC.
Tumor-Associated Macrophages Induce Migration of Renal Cell Carcinoma Cells via Activation of the CCL20-CCR6 Axis
Authors: Kadomoto Suguru , Izumi Kouji , Hiratsuka Kaoru , Nakano Taito , Naito Renato , Makino Tomoyuki , Iwamoto Hiroaki , Yaegashi Hiroshi , Shigehara Kazuyoshi , Kadono Yoshifumi , Nakata Hiroki , Saito Yohei , Nakagawa-Goto Kyoko , Mizokami Atsushi
Published: January 2020

This study investigated tumor-associated macrophages activity in the microenvironment of renal cell carcinoma. Via a co-culture with macrophage-like cells differentiated from human monocyte cell line THP-1 and U937 cells, the migration ability of ACHN and Caki-1 cells, which are human renal cell carcinoma cell line cells, was significantly increased, as was the epithelial–mesenchymal transition change. A chemokine array identified the CCL20-CCR6 axis as a concentration-dependent signal in ACHN and Caki-1 cell migration. Akt in the ACHN and Caki-1 cells was activated by macrophage-like cells, and the CCL20 neutralizing antibody suppressed migration ability, epithelial–mesenchymal transition, and Akt phosphorylation in the ACHN and Caki-1 cells. Akt inhibitor AZD5363 also decreased the epithelial–mesenchymal transition change and migration ability in the ACHN and Caki-1 cells. In 42 renal cell carcinoma tissues, patients with CCR6 and macrophage infiltration indicated poor prognoses. In the tumor microenvironment of renal cell carcinoma, cancer cells are activated by CCL20 secreted by tumor-associated macrophages through Akt activation, followed by epithelial–mesenchymal transition and an acquired migration ability. Thus, inhibition of the CCL20-CCR6 axis may be a potential therapeutic strategy for renal cell carcinoma.
Metabolic Reprogramming and Vulnerabilities in Cancer
Authors: Lyssiotis Costas A. , Nagrath Deepak
Published: January 2020

Metabolic programs are rewired in tumors to support growth, progression, and immune evasion. A wealth of work in the past decade has delineated how these metabolic rearrangements are facilitated by signaling pathways downstream of oncogene activation and tumor suppressor loss. More recently, this field has expanded to include metabolic interactions among the diverse cell types that exist within a tumor and how this impacts the immune system. In this special issue, 17 review articles discuss these phenomena, and, alongside four original research manuscripts, the vulnerabilities associated with deregulated metabolic programming are highlighted and examined.
Acute Myeloid Leukemia: Aging and Epigenetics
Authors: Zjablovskaja Polina , Florian Maria Carolina
Published: January 2020

Acute myeloid leukemia (AML) is an aggressive hematological disorder mainly affecting people of older age. AML initiation is primarily attributed to mutations in crucial cellular regulators such as epigenetic factors, transcription factors, and signaling genes. AML’s aggressiveness and responsiveness to treatment depends on the specific cell type where leukemia first arose. Aged hematopoietic cells are often genetically and/or epigenetically altered and, therefore, present with a completely different cellular context for AML development compared to young cells. In this review, we summarize key aspects of AML development, and we focus, in particular, on the contribution of cellular aging to leukemogenesis and on current treatment options for elderly AML patients. Hematological disorders and leukemia grow exponentially with age. So far, with conventional induction therapy, many elderly patients experience a very poor overall survival rate requiring substantial social and medical costs during the relatively few remaining months of life. The global population’s age is increasing rapidly without an acceptable equal growth in therapeutic management of AML in the elderly; this is in sharp contrast to the increase in successful therapies for leukemia in younger patients. Therefore, a focus on the understanding of the biology of aging in the hematopoietic system, the development of appropriate research models, and new therapeutic approaches are urged.
Gas Plasma-Conditioned Ringer’s Lactate Enhances the Cytotoxic Activity of Cisplatin and Gemcitabine in Pancreatic Cancer In Vitro and In Ovo
Authors: Liedtke Kim-Rouven , Freund Eric , Hermes Maraike , Oswald Stefan , Heidecke Claus-Dieter , Partecke Lars-Ivo , Bekeschus Sander
Published: January 2020

Pancreatic cancer is one of the most aggressive tumor entities. Diffuse metastatic infiltration of vessels and the peritoneum restricts curative surgery. Standard chemotherapy protocols include the cytostatic drug gemcitabine with limited efficacy at considerable toxicity. In search of a more effective and less toxic treatment modality, we tested in human pancreatic cancer cells (MiaPaca and PaTuS) a novel combination therapy consisting of cytostatic drugs (gemcitabine or cisplatin) and gas plasma-conditioned Ringer’s lactate that acts via reactive oxygen species. A decrease in metabolic activity and viability, change in morphology, and cell cycle arrest was observed in vitro. The combination treatment was found to be additively toxic. The findings were validated utilizing an in ovo tumor model of solid pancreatic tumors growing on the chorion-allantois membrane of fertilized chicken eggs (TUM-CAM). The combination of the drugs (especially cisplatin) with the plasma-conditioned liquid significantly enhanced the anti-cancer effects, resulting in the induction of cell death, cell cycle arrest, and inhibition of cell growth with both of the cell lines tested. In conclusion, our novel combination approach may be a promising new avenue to increase the tolerability and efficacy of locally applied chemotherapeutic in diffuse metastatic peritoneal carcinomatosis of the pancreas.
Low Temperature Dehydration of Glycerol to Acrolein in Vapor Phase with Hydrogen as Dilution: From Catalyst Screening via TPSR to Real-Time Reaction in a Fixed-Bed
Authors: Wang Xincheng , Zhao Fenghe , Huang Long
Published: January 2020

Temperature programmed surface reaction (TPSR) was developed as a method for rapid screening of catalysts. In this study, a series of acid catalysts was screened for the low-temperature dehydration of glycerol to acrolein via TPSR. Results suggested that most catalysts show activity of glycerol conversion to acrolein at a greatly different temperature range. HY, SiO2 supported H4SiW12O40 (STA/SiO2), SO42−/ZrO2, and SO42−/TiO2 were observed to be efficient for the conversion of glycerol into acrolein at 210 °C, which was significantly lower than that generally reported (250–340 °C). Moreover, high selectivity of acrolein was gained at 85% and 86% over SiW/SiO2 and SO42−/TiO2, respectively. A new style catalyst, ZnCl2/SiO2, was also found to be highly selective to acrolein and evaluated in a conventional fixed-bed reactor. Especially, stability tests showed that the catalyst life was up to 300 h with no clear deactivation on ZnCl2/SiO2 with hydrogen as dilution.
Catalysts for Suzuki–Miyaura Coupling Reaction
Authors: Len Christophe
Published: January 2020

Among the main reactions in organic chemistry, the Suzuki–Miyaura cross-coupling reaction catalyzed by a homogeneous or heterogeneous palladium complex is undoubtedly the most important [...]
Rhodium-Catalyzed Aqueous Biphasic Olefin Hydroformylation Promoted by Amphiphilic Cyclodextrins
Authors: Cocq Aurélien , Bricout Hervé , Djedaïni-Pilard Florence , Tilloy Sébastien , Monflier Eric
Published: January 2020

Hydroformylation is an industrial process that allows for the production of aldehydes from alkenes using transition metals. The reaction can be carried out in water, and the catalyst may be recycled at the end of the reaction. The industrial application of rhodium-catalyzed aqueous hydroformylation has been demonstrated for smaller olefins (propene and butene). Unfortunately, larger olefins are weakly soluble in water, which results in very low catalytic activity. In an attempt to counteract this, we investigated the use of amphiphilic oleic succinyl-cyclodextrins (OS-CDs) synthesized from oleic acid derivatives and maleic anhydride. OS-CDs were found to increase the catalytic activity of rhodium during the hydroformylation of water-insoluble olefins, such as 1-decene and 1-hexadecene, by promoting mass transfer. Recyclability of the catalytic system was also evaluated in the presence of these cyclodextrins.
Highlights on the Catalytic Properties of Polyoxometalate-Intercalated Layered Double Hydroxides: A Review
Authors: Stamate Alexandra-Elisabeta , Pavel Octavian Dumitru , Zavoianu Rodica , Marcu Ioan-Cezar
Published: January 2020

Layered double hydroxides (LDH) are an extended class of two-dimensional anionic materials that are known for their unique lamellar structure, versatile composition, and tunable properties. The layered architecture allows the intercalation between the positively charged sheets of a vast variety of anionic species, including oxometalates and polyoxometalates (POM). The hybrid composites that were developed using POM and LDH show great advantages when compared to both parent materials causing the appearance of new functionalities, which may lead to remarkable contributions in many areas of application, especially in catalysis. The current review paper emphases all of the crucial works already existing in literature that are related to the large group of POM-LDH solids and their use as catalysts for fine organic synthesis. The new trends in the development of the POM-LDH catalysts are highlighted based on the overview of 121 scientific articles that were published between 1984 and 2019. The main topics are focused primarily on the synthesis, characterization, and the catalytic applications of different LDH systems hosting polyoxometalates with low, medium, and high nuclearity. The intense exploration of the POM-LDH field has led to the obtaining of countless effective catalysts used in various types of reactions, from condensation, esterification, halodecarboxylation, to oxidation and epoxidation.
Experimental Design to Improve Cell Growth and Ethanol Production in Syngas Fermentation by Clostridium carboxidivorans
Authors: Benevenuti Carolina , Botelho Alanna , Ribeiro Roberta , Branco Marcelle , Pereira Adejanildo , Vieira Anna Carolyna , Ferreira Tatiana , Amaral Priscilla
Published: January 2020

Fermentation of gases from biomass gasification, named syngas, is an important alternative process to obtain biofuels. Sequential experimental designs were used to increase cell growth and ethanol production during syngas fermentation by Clostridium carboxidivorans. Based on ATCC (American Type Culture Collection) 2713 medium composition, it was possible to propose a best medium composition for cell growth, herein called TYA (Tryptone-Yeast extract-Arginine) medium and another one for ethanol production herein called TPYGarg (Tryptone-Peptone-Yeast extract-Glucose-Arginine) medium. In comparison to ATCC® 2713 medium, TYA increased cell growth by 77%, reducing 47% in cost and TPYGarg increased ethanol production more than four-times, and the cost was reduced by 31%. In 72 h of syngas fermentation in TPYGarg medium, 1.75-g/L of cells, 2.28 g/L of ethanol, and 0.74 g/L of butanol were achieved, increasing productivity for syngas fermentation.
A Multi-Enzymatic Cascade Reaction for the Synthesis of Vidarabine 5′-Monophosphate
Authors: Robescu Marina Simona , Serra Immacolata , Terreni Marco , Ubiali Daniela , Bavaro Teodora
Published: January 2020

We here described a three-step multi-enzymatic reaction for the one-pot synthesis of vidarabine 5′-monophosphate (araA-MP), an antiviral drug, using arabinosyluracil (araU), adenine (Ade), and adenosine triphosphate (ATP) as precursors. To this aim, three enzymes involved in the biosynthesis of nucleosides and nucleotides were used in a cascade mode after immobilization: uridine phosphorylase from Clostridium perfringens (CpUP), a purine nucleoside phosphorylase from Aeromonas hydrophila (AhPNP), and deoxyadenosine kinase from Dictyostelium discoideum (DddAK). Specifically, CpUP catalyzes the phosphorolysis of araU thus generating uracil and α-d-arabinose-1-phosphate. AhPNP catalyzes the coupling between this latter compound and Ade to form araA (vidarabine). This nucleoside becomes the substrate of DddAK, which produces the 5′-mononucleotide counterpart (araA-MP) using ATP as the phosphate donor. Reaction conditions (i.e., medium, temperature, immobilization carriers) and biocatalyst stability have been balanced to achieve the highest conversion of vidarabine 5′-monophosphate (≥95.5%). The combination of the nucleoside phosphorylases twosome with deoxyadenosine kinase in a one-pot cascade allowed (i) a complete shift in the equilibrium-controlled synthesis of the nucleoside towards the product formation; and (ii) to overcome the solubility constraints of araA in aqueous medium, thus providing a new route to the highly productive synthesis of araA-MP.
Ternary Hydrotalcites in the Multicomponent Synthesis of 4H-Pyrans
Authors: Nope Eliana , Sathicq Ángel G. , Martínez José J. , Rojas Hugo A. , Luque Rafael , Romanelli Gustavo P.
Published: January 2020

Lamellar double hydroxides (LDH) with double divalent cations were synthesized by the co-precipitation method and studied in the multicomponent synthesis of 4H-pyrans. The solids obtained were characterized by X-ray diffraction (XRD), infrared spectroscopy (FTIR), N2 adsorption isotherms, and thermogravimetric analysis (TGA). The XRD patterns confirmed the formation of LDHs in which the incorporation of Ni2+ or Co2+ improves their crystalline and textural properties. The results of catalytic activity showed that the synthesis of 4H-pyrans is favored in solvent-free conditions with the LDH–Ni catalyst, avoiding calcination processes. In addition, it was found that hydrotalcite with double divalent cations can conduct this reaction through multicomponent synthesis or by the Michael addition reaction, which can be performed by different types of basicity that depend on the composition of another divalent cation in the brucite layer or a calcination process.