bluuebunny/crossref_metadata_2025 huggingface dataset:
Development and application of fourth-order-accurate semi- implicit scheme for compressible viscous flow
Authors: Wang Hao , Liu Yanming
Published: January 2023

In this paper, a semi-implicit time discretization scheme with fourth-order accuracy is constructed and applied to compressible Navier-Stokes equations. The scheme is composed of explicit basis scheme and adding implicit items, which can achieve the accuracy of explicit basis scheme after modification, and has a better stability. The explicit basis scheme is constructed by combining Runge-Kutta and linear multi-step method to satisfy the underdetermined equations with sufficient free parameters required by the accuracy condition, and the free parameters are chosen to fulfill the implicit method's requirements. To alter the implicitness, an implicit term with a configurable parameter γ is inserted at each stage of the explicit scheme. The linear stability of the model equation is analyzed for the obtained implicit scheme, which is A-stable. The scheme is applied to the space-time decoupled compressible N-S equation. In order to reduce the scale of matrix operation and further improve the stability, the LU-SGS method is used to calculate the implicit operator matrix, and the technique is used in conjunction with the dual-time step approach. Some classical cases are used to verify the calculation effect of the scheme on shock wave capture, low-speed turbulence, and shock wave/boundary layer interference. The results show that the scheme can ensure accuracy and stability of the scheme under a large physical time step, and the calculation efficiency is higher than the traditional method.
Melatonin induces cell apoptosis in renal carcinoma cells via regulating mitochondria function, promoting ROS production, and suppression of Akt/mTOR/S6K signaling pathway
Authors: Xue Kaihua , Jiang Yifan , Bai Jiyu , Zhang Dize , Chen Yuhang , Ma Jianbin , Zhu Zhijing , Wang Xinyang , Guo Peng
Published: January 2023

Purpose
In recent years, metabolic alteration has been identified as a driver in the development of renal cell carcinoma (RCC), which plays a critical role in cancer cells to adapt to hypoxic environment and cell proliferation. Melatonin (MLT), a neurohormone secreted during the dark hours by the vertebrate pineal gland, induces metabolic reprogramming in cancer cells by suppression of aerobic glycolysis. Whether it can be used as a potential therapeutic tool in RCC is worth exploring.
Methods
In this study, we detected concentration of metabolites in RCC cells through metabo-lomic analyses using UPLC-MS/MS and the oxygen consumption rate was determined using the Seahorse Extracellular Flux analyzer.
Results
We found that MLT significantly inhibited proliferation and induced apoptosis in RCC cells, moreover, MLT increased ROS level and inhibited the activity of antioxidant enzymes. Furthermore, MLT up-regulated key TCA cycle metabolites while reduced aerobic glycolysis products, and induced higher oxygen consumption rate, more ATP production, and higher membrane potential in RCC cells, indicating that MLT enhances mitochondrial function and re-vert aerobic glycolysis to mitochondrial OXPHOS in RCC cells. Moreover, MLT treatment inhibited the phosphorylation levels of Akt, mTOR, and p70 S6 Kinase in RCC cells, while the application of NAC (inhibitors of ROS) not only restored the phosphorylation of these proteins but also decreased cell apoptosis. Consistently, MLT treatment significantly inhibited growth of RCC cell xenografts in nude mice.
Conclusion
Our results indicate that MLT treatment promotes intracellular ROS production via metabolic reprogramming and reducing antioxidants, which suppressed the activity of Akt/mTOR/S6K signaling pathway and induced apoptosis in RCC cells.
Epipelon biomass responses to different restoration techniques in a eutrophic environment
Authors: Costa Renata Aparecida , Ferragut Carla
Published: January 2023

Eutrophication is a worldwide problem. In eutrophic shallow lakes, phosphorus release from stored sediment hinders restoration processes. The epipelon is a community that grows attached to the sediment surface and has the potential to help P retention by autotrophic organisms. This study evaluated epipelon responses to four shallow lake restoration techniques. The responses of abiotic variables and phytoplankton biomass were also evaluated. Four simultaneous mesocosm experiments were performed in a shallow eutrophic lake. The applied techniques were aeration, flocculant, floating macrophytes, and periphyton bioreactor. Water and epipelon samples were taken on days 3, 10, 17, 27, and 60. The aeration treatment and macrophytes shaded the epipelon, which had a predominance of heterotrophic components. Flocculant and periphyton bioreactor treatments favored epipelon growth with a higher contribution of autotrophic components. Therefore, some techniques may favor the epipelon growth, while others may harm the community in restoration processes. For the complete restoration of a lacustrine ecosystem, the choice of techniques to be applied must consider the restoration and maintenance of the benthic environment.
DT-13 attenuates inflammation by inhibition of NLRP3-inflammasome in RAW264.7 macrophages
Authors: Raina Shikha , Hübner Emely , Samuel Esther , Nagel Gregor , Fuchs Hendrik
Published: January 2023

Background: Plant derived saponins or other glycosides are widely used for their anti-inflammatory, antioxidant, and anti-viral properties in therapeutic medicine. In this study, we focus on understanding the function of the less known steroidal saponin from the roots of Liriope muscari L.H.Bailey – saponin C (also known as DT-13) in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages in comparison to the well-known saponin ginsenoside Rk1 and dexamethasone.
Results: We proved that DT-13 reduces LPS-induced inflammation by inhibiting nitric oxide (NO) production, interleukin-6 (IL-6) release, cycloxygenase-2 (COX-2) and tumour necrosis factor-alpha (TNF-α) gene expression, and nuclear factor kappa-B (NFκB) translocation into the nucleus. It also inhibits the inflammasome component NOD-like receptor family pyrin domain containing protein 3 (NLRP3) regulating the inflammasome activation. This was supported by the inhibition of interleukin 1 beta (IL-1β) and caspase-1 levels.
Conclusion: This study demonstrates the anti-inflammatory effect of saponins on LPS-stimulated macrophages. For the first time, an in vitro study shows the attenuating effect of DT-13 on NLRP3-inflammasome formation. In comparison to the existing anti-inflammatory drug, dexamethasone, and the triterpenoid saponin from ginseng plant, Rk1, DT-13 more efficiently inhibits inflammation in the applied cell culture model. Therefore, DT-13 may serve as a lead compound for the development of new more effective anti-inflammatory drugs with minimized side effects.
Vascular Wall Microenvironment: Exosomes Secreted by Adventitial Fibroblasts Induced Vascular Calcification
Authors: Zheng Minghui , Shan Sukang , Lin Xiao , Xu Feng , Wu Feng , Guo Bei , Li Fuxingzi , Zhou Zhiang , Wang Yi , Lei Limin , Tang Kexin , Duan Jiayue , Wu Yunyun , Cao Yechi , Liao Xiaobo , Yuan Lingqing
Published: January 2023

Vascular calcification often occurs in patients with chronic renal failure (CRF), which significantly increases the incidence of cardiovascular events in CRF patients. Our previous studies identified the crosstalk between the endothelial cells (ECs) and vascular smooth muscle cells (VSMCs), and the paracrine effect of VSMCs, which regulates the calcification of VSMCs. Herein, we aim to investigate the effects of exosomes secreted by high phosphorus (HPi) -induced adventitial fibroblasts (AFs) on the calcification of VSMCs, which will construct the novel theory of “Vascular Wall Microenvironment”. The conditioned medium of HPi-induced AFs promotes the calcification of VSMCs, which is partially abrogated by GW4869, a blocker of exosomes biogenesis or release. Exosomes secreted by high phosphorus-induced AFs (AFsHPi-Exos) show similar effects on VSMCs. miR-21-5p is enriched in AFsHPi-Exos, and miR-21-5p enhances osteoblast-like differentiation of VSMCs by downregulating Crim1 expression. AFsHPi-Exos and exosomes secreted by AFs with overexpression of miR-21-5p (AFsmiR21M-Exos) significantly accelerate vascular calcification in CRF mice. In general, the enriched miR-21-5p in AFsHPi-Exos promotes the calcification of VSMCs and vascular calcification by inhibiting the expression of cysteine-rich Crim1 protein (Crim1). Combined with our previous studies, the present experiment supports the theory of vascular wall microenvironment.
Transcatheter Closure of a Coronary Artery Fistula in a Neonate with Tetralogy of Fallot
Authors: Peck Daniel , Bass John L , Berry James M , Tainter Brianne S , Sinha Pranava , Aggarwal Varun
Published: January 2023

Coronary artery-to-pulmonary artery fistulae (CAPF) are a not uncommon finding in patients with Tetralogy of Fallot (TOF) and collateral dependent pulmonary blood flow. Management for these fistulae is often primary surgical ligation or unifocalization at the time of complete repair, dependent on the presence of dual blood flow to the involved areas. We present the case of a 32-week premature boy weighing 1.79 kg with TOF, confluent branch pulmonary arteries, major aortopulmonary collaterals and right coronary artery to main pulmonary artery fistula. The patient demonstrated evidence of coronary steal into the pulmonary vasculature with an elevation in the troponin level without hemodynamic instability, and subsequently underwent successful trans-catheter occlusion of the fistula via right common carotid access using a Medtronic 3Q microvascular plug. This case demonstrates the realistic potential for early coronary steal in this physiology and possibility of trans-catheter therapy even in a small neonate.
Selection of a Sustainable Supplier by Using a Fuzzy MCDM Mathematical Modelling
Authors: Agarwal Reema , Agrawal Ankur , Kumar Nitendra , Ray Samrat , Voumik Liton Chandra
Published: January 2023

The primary objective of any business today is to remain competitive and sustainable so that it may continue operating profitably and efficiently. Therefore, in order to achieve the aforementioned goals, businesses must evaluate potential sustainable suppliers in light of the three pillars of sustainability (social responsibility, economic viability, and environmental friendliness). One example of an issue that requires multiple criterion decision-making (MCDM) is the challenge of finding sustainable suppliers. Fuzzy PROMETHEE, a method of multi-criteria decision making (MCDM) that utilizes triangular fuzzy numbers (TFNs) and linguistic concepts, is used in this study to establish the relative importance of three factors for choosing a sustainable supplier: social impact, economic viability, and environmental responsibility. Successful application of the fuzzy PROMETHEE method has allowed the organization's managers to arrive at the appropriate conclusion and implement the necessary solution.
The accessibility and safety of inserting proximal basilic and axillary veins central lines in neonates
Authors: Aly Hany , Qattea Ibrahim , Farghaly Mohsen A A , Mohamed Mohamed A
Published: January 2023

Purpose of review: to evaluate the accessibility, success rate, and attributable complications and to describe the maneuver for PICC line insertion via proximal basilic or axillary veins in neonates.
Recent findings: This study demonstrated a total of 78 PICCs inserted successfully 91.7% and fewer complications. The median postnatal age of patients was eight days (2 days - 92days), and the median weight of patients at the procedure was 2600g (590g - 3900g). The median corrected gestational age of patients at the procedure was 36weeks (23weeks - 46weeks).
Summary: This study demonstrated a high success rate and fewer complications of proximal basilic and axillary veins central lines in neonates with difficulties getting intravenous vascular access. This procedure is also safe for Very low birth and extremely low birth Preterm and can be used as central intravenous access for a long time.
Cord Blood Procalcitonin and N-terminal Pro-brain Natriuretic Peptide: Biomarkers for Early Prediction of Bronchopulmonary Dysplasia
Authors: Cui Xuewei , Fu Jianhua
Published: January 2023

Background: This study focused on determining whether cord blood procalcitonin (PCT) and N-terminal pro-brain natriuretic peptide (NT-proBNP) concentrations could accurately predict bronchopulmonary dysplasia (BPD) in preterm infants.
Methods: Overall, 452 preterm infants were included in this prospective cohort trial and were divided into groups according to their BPD diagnoses. We evaluated PCT and NT-proBNP concentrations in cord blood. The effectiveness of determining cord blood PCT and NT-proBNP concentrations in predicting BPD was assessed using the receiver operating characteristic curve analysis. Multivariable logistic regression analyses and mediation analyses were used to analyze the risk variables for BPD and the associations of the two biomarkers with perinatal factors and neonatal outcomes.
Results: Concentrations of the two biomarkers were greater in the cord blood of preterm infants with BPD than in the No-BPD group (P < 0.001). The appropriate cutoff values for cord blood PCT and NT-proBNP to predict BPD were 0.28 ng/mL and 2,460.50 pg/mL, respectively. In the multivariable logistic regression analysis, fetal inflammatory response syndrome (FIRS), respiratory distress syndrome, and the two cord blood biomarker levels were identified as significant risk factors for BPD (odds ratio [OR] = 1.55–3.72). The concentration of cord blood PCT accounted for 26.4% and 34.6% of the association between FIRS and chorioamnionitis with BPD, respectively. The two cord blood biomarkers were found to be strongly associated with the incidence of neonatal outcomes (OR = 1.27–2.58).
Conclusions: Cord blood PCT and NT-proBNP concentrations may be valuable noninvasive predictive indicators of BPD development in preterm newborns.
Trial registration: This study was registered on the website http://www.chictr.org.cn/listbycreater.aspx (number ChiCTR2100052175).
Sex differences in grey matter networks in dementia with Lewy bodies
Authors: Habich Annegret , Oltra Javier , Schwarz Christopher G , Przybelski Scott A , Oppedal Ketil , Inguanzo Anna , Blanc Frédéric , Lemstra Afina W , Hort Jakub , Westman Eric , Lowe Val J , Boeve Bradley F , Dierks Thomas , Aarsland Dag , Kantarci Kejal , Ferreira Daniel
Published: January 2023

Objectives Sex differences permeate many aspects of dementia with Lewy bodies (DLB), including epidemiology, pathogenesis, disease progression, and symptom manifestation. However, less is known about potential sex differences in patterns of neurodegeneration in DLB. Here, we test whether grey matter networks also differ between female and male DLB patients. To assess the specificity of these sex differences to DLB, we additionally investigate sex differences in healthy controls (HCs). Methods A total of 119 (68.7 ± 8.4 years) male and 45 female (69.9 ± 9.1 years) DLB patients from three European centres and the Mayo Clinic were included in this study. Additionally, we included 119 male and 45 female age-matched HCs from the Mayo Clinic. Grey matter volumes of 58 cortical, subcortical, cerebellar, and pontine brain regions derived from structural magnetic resonance images were corrected for age, intracranial volume, and centre. Sex-specific grey matter networks for DLB patients and HCs were constructed by correlating each pair of brain regions. Network properties of the correlation matrices were compared between sexes and groups. Additional analyses were conducted on W-scored data to identify DLB-specific findings. Results Networks of male HCs and male DLB patients were characterised by a lower nodal strength compared to their respective female counterparts. In comparison to female HCs, the grey matter networks of male HCs showed a higher global efficiency, modularity, and a lower number of modules. None of the global and nodal network measures showed significant sex differences in DLB. Conclusions The disappearance of sex differences in the structural grey matter networks of DLB patients compared to HCs may indicate a sex-dependent network vulnerability to the alpha-synuclein pathology in DLB. Future studies might investigate whether the differences in structural network measures are associated with differences in cognitive scores and clinical symptoms between the sexes.
Item-response theoretical examinations of a lot of bullshit: Evaluations of measures of bullshit production and reception
Authors: Blötner Christian
Published: January 2023

Scholars developed and probed measures of individual receptivity to and production of ambiguous, empty, or otherwise deceptive information intended to gain advantages or to avoid disadvantages (so-called bullshit). All recent endeavors to scale development and evaluation were limited to classical test theory, but no study has yet applied item response theory(IRT). In four studies (Ns = 125, 409, 300, and 525), most of the items of the Bullshit Receptivity Scale, the Scientific Bullshit Receptivity Scale, and the Bullshitting Frequency Scale revealed appropriate IRT properties in the polytomous graded response model. However, in some cases, sufficient information could be obtained only within relatively narrow spectra or gaps of obtainable information occurred along the spectra. Furthermore, bullshit and real information statements did not function equally well. Last, statistical concerns with frequently employed bullshit sensitivity scores were discussed and recommendations for further efforts concerning item development were expressed.
Epidemiological manifestations and burden of healthcare-associated infections in Libyan national hospitals
Authors:   Mohamed Ali Daw1,   Mahamat Hassabarassoul Mahamat2
Published: January 2023

Background
Healthcare-associated infection is a serious global problem, particularly within developing countries. In Northern African countries comprehensive research on the prevalence and effects of such infections was rarely carried out. The objectives of this study were aimed to evaluate the epidemiology and determine the burden of healthcare-associated infections in Libyan national teaching hospitals.
Methods
A prospective longitudinal study was carried out in the four largest teaching and referral hospitals in Libya including Tripoli Medical Centre, Tripoli-Central Hospital, Benghazi Medical Centre, and Sebha Medical Centre within a year from November 1, 2021, to October 31, 2022. The epidemiological events and the parameters incorporated in this study were based on the data published by the Centre for disease control. The surveillance analysis was carried out on all patients admitted to medical wards, surgical, ICU, gynecology & obstetrics, and pediatrics in all four hospitals. Trained staff reviewed medical records and the percentages of patients with health care–associated infections were compared. Bio-statistical and multivariable logistic regression analyses were carried out to test variables associated with HAI events and the resulting deaths.
Results
A total of 22170 hospitalized patients in four hospitals were included in the study. Hospital-acquired infection was reported among 3037 patients with an overall prevalence of 13.7% (95% CI:12.9%- 14.4%). Interestingly the prevalence varied among the hospitals studied. The highest was reported in Benghazi Medical Centre reported (17.9 % (95% CI:16.9%- 18.71%), followed by Sebha Medical Centre (14.8% (95% CI:14.5.9%- 16.51%). Surgical site infection was the highest (31.28 %), followed by Ventilator-associated pneumonia (29.34 %), urinary tract infections (26.84 %), and Bloodstream infection (12.55 %). Patients with HAIs experienced severe morbidity that required intervention. New antimicrobial regimens were needed for 1836(93 %) patients and 752(34 %) required ICU admission. In addition to surgical intervention, respiratory support, and inotropes were needed as a consequence of HAI events.
Conclusions
The prevalence of Healthcare-associated infection in Libyan hospitals was found to be high and it should be considered a major problem with a serious burden. Hospital management should be alerted, indicating an urgent need to intervene at the national and hospital levels to implement preventive and control strategies to combat HAI.
Photochemical Synthesis of Silver Nanoparticles Using UV LEDs Under Diﬀerent Citrate and PVP Concentrations
Authors: Ribeiro Marlon S , Truchiello Rozane F , Gomez Sergio L
Published: January 2023

The photochemical synthesis of plasmonic nanoparticles (NPs) has many advantages compared to chemical routes, including synthesis at room temperature, control of the outcomes, and no harmful reactants. Herein, the results of employing UV LEDs for the photochemical synthesis of stable aqueous solutions of citrate-capped and polyvinylpyrrolidone (pvp)+citrate-capped Ag nanoparticles are reported. The size of the NPs does not depend on the quantity of citrate, although increasing the amount of PVP reduced their size and number. The results also showed evidence of a reverse Ostwald ripening process induced by UV light.
Secular Trends in Head Size and Cerebral Volumes In the Framingham Heart Study for Birth Years 1902-1985
Authors: DeCarli Charles , Pase Matthew , Beiser Alexa , Kojis Daniel , Satizabal Claudia , Himali Jayandra , Aparicio Hugo , Flether Evan , Maillard Pauline , Seshadri Sudha
Published: January 2023

Background
Recent data suggest that dementia incidence is declining. We investigated whether similar secular trends consisting of increasing size of brain structures and improving memory performance could be simultaneously occurring as a possible explanation.
Method
The Framingham Heart Study is a 3 generation, longitudinal study that includes cognitive assessment and medical surveillance. This study cohort consisted of 4,506 unique, non-demented, stroke free, individuals with brain MRI, cognitive assessment, and demographic information spanning dates of birth from 1902 to 1985. Outcomes consisted of height, MRI, and memory measures. Covariates included age at MRI, sex, decade of birth, and all interactions. Models with neuropsychological outcomes also included educational achievement as a covariate.
Results
Height and intracranial (TCV), hippocampus and cortical gray matter volumes were significantly larger, and memory performance significantly better, with advancing decades of birth after adjusting for age, sex, and interactions. Sensitivity analysis using progressively restricted age-ranges to reduce the association between age and decade of birth, confirmed the findings. Mediation analysis showed that hippocampal volume mediated approximately 5-7% of the effect of decade of birth on logical memory performance.
Discussion
These findings indicate improvement in brain health and memory performance with advancing decades of birth. Although brain structures are under substantial genetic influence, we conclude that improved early life environmental influences over ensuing decades likely explain these results. We hypothesize that these secular improvements are consistent with declining dementia incidence in this cohort potentially through a mechanism of increased brain reserve.
A case report of rare occurrence of giant cell tumour in calcaneum misdiagnosed as ankle sprain
Authors: Samri Shafora Bibi , Ahmed Wan Aireene Wan
Published: January 2023

Background

Giant cell tumour (GCT) of the bone is locally aggressive benign bone tumour commonly occur at distal femur and proximal tibia and rarely found in calcaneus. GCT occurrence at atypical location especially at ankle may be mistakenly as trivial complaint such as ankle sprain, thus not prompt further investigation by treating doctors.

Case presentation

Our case was a 32-year-old female who was presented with left foot swelling for a period of 8 months, progressively increased in size over last 3 months. Right foot examination showed a minimal swelling at posterior ankle region. Plain radiograph showed a well-defined slightly expansile lytic lesion with non-sclerotic margin at posterior part of calcaneus. A core biopsy of the lesion demonstrated scattered osteoblastic type giant cells in the background of abundant mononuclear cells suggestive of a GCT.

Conclusions

GCT rarely involves calcaneus with incidence of about 1%, in such a case making its diagnosis challenging because of its rarity. We highlight the importance for clinicians to have high level of suspicion for bone tumour instead of ignoring patient’s complaint and further evaluate with appropriate imaging.
Pragmatic anaesthetic approach for extracranial to intracranial (ECIC) bypass surgery in a patient with Moyamoya disease and Sickle cell disease.
Authors: Lal Shankar , Larney Vivienne
Published: January 2023

Background
Moyamoya disease is a chronic progressive cerebrovascular disorder. 10–20% of patients with sickle cell disease have associated moyamoya disease (MMD) and may require surgical revascularisation as definitive treatment.
Case presentation:
A patient with sickle cell disease and moyamoya disease with extensive cerebral vasculopathy was scheduled for elective ECIC bypass surgery. She presented with right-sided weakness secondary to a haemorrhagic stroke of the left lentiform nucleus. She required a multidisciplinary team approach for pre-procedural optimisation. Her preoperative HbSS levels were reduced to less than 20% with preoperative red blood cell transfusion to avoid sickling. We maintained normal physiology and optimal analgesia peri-operatively. She was extubated after the successful surgical procedure and was transferred to ICU for invasive monitoring, with subsequent discharge to the ward several days later.
Conclusion
Optimal pre-procedural optimisation can decrease complications in patients with critically comprised cerebral circulation booked for extensive surgery such as ECIC bypass. We believe the presentation of anaesthetic management of a patient with moyamoya disease and sickle cell disease may prove helpful.
A numerical study of the Peridynamic Differential Operator discretization of incompressible Navier-Stokes problems
Authors: Aksoylu Burak , Celiker Fatih
Published: January 2023

We study the incompressible Navier-Stokes equations using the Projection Method. The applications of interest are the classical channel flow problems such as Couette, shear, and Poiseuille. In addition, we consider the Taylor-Green vortex and lid-driven cavity applications. For discretization, we use the Peridynamic Differential Operator (PDDO). The main emphasis of the paper is the performance of the PDDO as a discretization method under these flow problems. We present a careful numerical study with quantifications and report convergence tables with convergence rates. We also study the approximation properties of the PDDO and prove that the $N$-th order PDDO approximates polynomials of degree at most $N$ exactly. As a result, we prove that the PDDO discretization guarantees the zero row sum property of the arising system matrix.
Geri Dönüşüm Süreci İçin Yeni Bir Bulanık Envanter Modeli
Authors: ÇELİK EROĞLU Şeyma , ŞAHİN Yusuf
Published: January 2023

Kullanım ömrü sona eren ürünlerin çeşitli işlemlerden sonra yeniden kullanılabilir hale getirilmesi çevresel, ekonomik ve sosyal alanlarda insanoğluna birçok fayda sağlar. Çevrenin korunması, hammadde ihtiyacının azalması, kaynakların ekonomik kullanımı ve kirliliğin azaltılması gibi faydaları nedeniyle de geri dönüşüm sektörünün önemi dünya çapında giderek artmaktadır. Bu çalışmada, geri dönüşüm sürecini içeren bulanık bir stok modeli önerilmiştir. İlk olarak, Dobos ve Richter (2003) tarafından geliştirilen sabit talep ve geri dönüş oranlarına sahip genişletilmiş bir üretim/geri dönüşüm modeli atıkların yok edilme süreci ve oluşacak stok düzeyi bakımından yeniden düzenlenmiştir. Ardından talep, marjinal geri alma ve marjinal kullanım oranı parametreleri yamuk bulanık sayı olarak kabul edilip model bulanıklaştırılmıştır. Durulaştırma işlemi için kademeli ortalama entegrasyon temsil yöntemi kullanılmıştır. Böylece birim zamandaki toplam maliyet ve optimal çevrim süresi deterministik değerler olarak ifade edilmiştir. Çözülen problemin sonuçları değerlendirildiğinde, önerilen bulanık stok modelinin temel alınan deterministik stok modeline kıyasla çevrim süresi bakımından daha iyi sonuçlar verdiği gözlemlenmiştir.
Eşli Çalışan Düşey Eksenli Türbin Performansının İki Boyutlu Benzetimi
Authors: AKGÜL Ufuk , KÖKEY İskender , TURGUT Alpaslan , KARADENİZ Z. Haktan
Published: January 2023

Rüzgar enerji santralindeki (RES) türbinlerin birbirine göre konumları oldukça önemlidir. Bu açıdan önemli hususlardan biri de, birbirine yakın konumda çalışan iki düşey eksenli türbinin (DERT) birbirlerinin performansına olan etkisidir. Literatürde gösterilmiş olan, birlikte çalışan DERT’lerin performansındaki yükselişin nedenlerinin araştırılması gerekmektedir. Saha testlerinde rüzgâr hızlarının tam olarak kontrol edilememesi ve düşey eksenli türbinin kanat dışındaki yapısal elemanlarının akış bozucu etkisi olması, problemin daha basit haliyle, iki boyutlu bilgisayar benzetimi yöntemiyle incelenmesini zorunlu kılmıştır. Bu amaçla çalışma kapsamında, düşey eksenli türbinin akışı bozacak parçalarını ihmal ederek, farklı merkezler arası uzaklığa (1,5, 2, 2,5 ve 4) sahip eşli çalışan iki türbinin performansının farklı uç hız oranlarında (0,5, 1, 1,5, 2, 2,5 ve 3 uç hız oranı) tek çalışan türbine göre nasıl değiştiği iki boyutlu bilgisayar benzetimleriyle incelenmiştir. Eşli çalışma durumunda türbin performansının tek çalışmaya göre %26 yükseldiği görülmüştür. Bu yükselişin ana etkeninin blokaj etkisi olduğu, yanal hızların ve iki türbin ara bölgesinde hızlanan akış gibi etkilerin ise daha az olduğu saptanmıştır.
Yazılım Ürün Hatlarında Tam Üründen Özellik Eksiltme Yoluyla Farklı Ürün Yapılandırmalarını Otomatik Üretme Yöntemi
Authors: ÖZTÜRK KAYA Dilek , TUĞLULAR Tuğkan
Published: January 2023

Yazılım ürün hattı (YÜH) karmaşık, büyük ölçekli ve ürün yapılandırması bakımından zengin yazılım sistemleri geliştirmek için gelelecek vadeden bir yaklaşımdır. Yazılım ürün hattındaki sayısı çok fazla olabilen ürün yapılandırmalarına ait modellerin otomatik elde edilmesi zaman ve maliyet kısıtları açısından oldukça önemlidir. Bu çalışmada, ürün modellerini daha üretken ve etkili şekilde elde edebilmek için, tam ürün modelinden, özellik eksiltme yoluyla farklı ürün yapılandırmalarına ait modelleri otomatik olarak elde etmeyi sağlayan bir yaklaşım önerdik. Önerilen yaklaşımı İçecek Otomatı YÜH, Banka Hesabı YÜH ve Öğrenci Yoklama Sistemi YÜH isimli üç farklı vaka çalışması üzerinde denedik. Özellik-bağımlılık ağacı ve dinamik kenar eşleme algoritması bu çalışmada önerilen özgün kavramlardır.
New Perspectives about Maxillary Sinus Lifting: a Literature Review
Authors: Barros Mariana Silva , Amaral Regiane Cristina do , Pedron Irineu Gregnanin , Shinohara Elio Hitoshi , Gaujac Cristiano
Published: January 2023

Maxillary sinus lifting is a procedure for bone height gain in atrophic jaws. New safe and less complex manners have been evalueted, which use modifications of conventional techniques, through technologies such as devices and equipment that make them less traumatic. This study aims to conduct a literature review of articles found in the PubMed database between the years 2015 and 2020 that addresses advances in Maxillary sinus lifting techniques. We noticed that there is a development in the techniques that promotes the reduction of operative time, perforations and consequently a better postoperative for the patient, reducing the unpleasant perception of the surgery. The use of surgical ultrasound reduces the trauma to the soft tissues and the number of membrane perforations. A great step in the development of the sinus membrane lifting technique was the perception that bone formation is possible with the detachment of the membrane, not requiring the placement of a graft. There is no technique that replaces Maxillary Sinus Lifting yet. Only to improve it.
RHETORIC ANALYSIS ON STAND UP COMEDY
Authors: Yolandari Nuzulul Fitri
Published: January 2023

This kind of discourse has some specific characteristics in terms of its creation and language use. A qualitative study was conducted with the data source from stand-up comedy records. The data were reduced to obtain the funniest humor discourse. Furthermore, the data were analyzed based on the creation technique and the construction elements of humor discourse in terms of linguistic and non-linguistic context. The research findings showed that the creation technique and the construction elements of stand-up comedy humor discourse in local perspective in Indonesia were in line with the general concepts and theories of humor discourse creation techniques namely: (a) rhetoric, (b) tone variation, (c) irony, (d) language misunderstanding, (e) wordplay, (f) verbal jokes, (g) sarcasm, (h) satire, (i) sexual satire, and (j) deception. In addition, the results confirmed that the most widely used of creation techniques were rhetoric, wordplay, and deception. The three techniques are more pronounced than other techniques due to the local comics circumscribed public speaking capability.
KEMAMPUAN BERPIKIR KRITIS SISWA DALAM MENULIS TEKS DESKRIPSI MENGGUNAKAN MEDIA VIDEO PENGETAHUAN ALAM KELAS VII SMP
Authors: Batubara Siti Aisah
Published: January 2023

Penelitian ini bertujuan untuk melihat pengaruh media video pengetahuan alam terhadap kemampuan berpikir kritis siswa dalam menulis teks deskripsi pada siswa kelas vii smp siman jaya lamongan. Jenis penelitian yang digunakan adalah Quasi eksperimen, desain eksperimen yang digunakan dalam penelitian ini adalah pretest-posttest control group design. Teknik pengumpulan data dilakukan dengan metode nontes berupa penugasan menulis teks teks deskripsi. Teknik analisis data menggunakan uji t dengan taraf signifikan 5% (0,05). Hasil penelitian menunjukkan bahwa adanya pengaruh media video pengetahuan alam terhadap kemampuan berpikir kritis siswa dalam menulis teks deskripsi pada siswa kelas VII SMP Siman Jaya Lamongan. Hasil penelitian ini diharapkan dapat memberi tambahan pengetahuan tentang teori pembelajaran menulis teks deskripsi, serta memberi tambahan pengetahuan bagi tenaga pendidik untuk mengelola proses belajar pembelajaran untuk mencapai tujuan pembelajaran
Don’t let the little man live in your head for free. an interpretive phenomenological analysis of seafarers with reportedly high levels of well-being
Authors:   , Brown Lauren
Published: January 2023

The mental health of seafarers has become a growing issue of concern and has attracted the attention of researchers in recent times. Seafarers are predominantly men, spend months at sea with little to no contact with loved ones ashore, and usually must reside in confined spaces that often contain substantial levels of noise and heat. The underlying causes of mental illness among seafarers are known. Some of the causes include sleep deprivation, occupational stress, marital/relationship problems, fatigue, the threat of piracy, psychosocial workload, loneliness, social isolation, separation from families, lack of shore leave, cultural issues, and job security. Despite these stressors, there are many men and women seafarers who flourish in the industry and enjoy their careers. Very little research has been conducted into the well-being practices of those seafarers who enjoy high levels of well-being. This study explores the lived experiences of a group of seafarers with reportedly high levels of psychological well-being, as well as their experiences of workplace stressors and mental health interventions offered by the industry. This study is an interpretive phenomenological analysis, which is epistemologically underpinned by phenomenology, hermeneutics and idiography. Results revealed four focus areas: general lived experiences across two worlds and how this relates to identity, what seafarers with reportedly high levels of psychological well-being experience as stressors, well-being practices of these seafarers and how these seafarers experience and make sense of mental health interventions they have come across.
Implementing The Use of AI for Analysis and Prediction in the Fashion Industry
Authors: Renaningtyas Luri , Dwitasari Putri , Ramadhani Nugrahardi
Published: January 2023

The COVID-19 pandemic has made all aspects of human life assisted by technology and big data. It starts from the education sector, economy, communication, health, and manufacturing to fashion. As we all know fast fashion has become one of the most significant contributors of waste.  During the flow of developing a collection, for example; the production and distribution process can cause ethical issues and contradict sustainability matters. Several studies from 2010 to date have initiated AI (Artificial Intelligent) technology, a computer vision that alleviates the use of carbon footprints in the fashion industry. AI presents robust evidence to the audience, since it is visual and statically calculated, furthermore it is less costly and energy saving. AI abstracts the similarities or differences across all clothing and collections from the dataset. Its implementation can be used in many fashion careers with different purposes. By reviewing across the computer vision journals complemented with fashion management literatures, this article eventually provides insights of the implementation of AI for analysis and prediction from fashion photos or dataset.
The Challenges of Building Sustainable Cities in Cameroon: Health Issues Associated with a Rapid Urban Population Increase in Buea Municipality.
Authors: Monono Eyole , Zinyemba Tatenda
Published: January 2023

Rapid urbanization compounded by urban poverty is one of the main challenges facing many Sub-Saharan African countries. The Buea municipality is the 10th largest city in Cameroon and equally faces such problems brought about by unplanned development in the past four decades. In 2020, the population growth rate in Buea rose to 42% compared to 5.6% in 2005, especially in the peri-urban areas. This resulted in direct and indirect pressures on available resources. Since 2019, Buea has been hosting close to 100,000 Internally Displaced Persons (IDPs) fleeing from the conflict between the defense and security forces and the separatist groups operating in the South West and North West Regions. Consequently, this expansion of urban agglomerations in Buea brings about challenges for the urbanites whose standard of living within the urban space is affected. This article seeks to qualitatively examine how this rapid urbanization has contributed to this recurrence of cholera outbreak since 2019 and the effects on the healthcare system and measures that are in place to mitigate this outbreak. In addressing these issues, the study administered in-depth phone Interviews with medical practitioners at Buea Regional Hospital, which is the main Cholera Treatment Centre in Buea. It also conducted in-depth phone interviews with public health experts at the South West Regional Delegation of Public Health and Buea Council personnel incharge of hygiene and sanitation. The study also made use of direct observation of the researcher on the field during sensitization campaigns in the affected communities in Buea. Base on the results the influx of IDPs have stress the already existing sanitation and shortage/rationing of water in the town. The study also found out that governance and cultural issues are equally associated to the problem of recurrence of the cholera disease in Buea Municipality.
Interior design and furniture in traditional dwellings in the old towns between modernity and preservation of cultural heritage (a special case in the old city of Hebron)
Authors: Shaded Wisam
Published: January 2023

This paper discusses the repercussions, challenges, and conditions imposed by the living occupancy in traditionaldwellings with the signature spatial organization in the old cities in general and in the Old City of Hebron/Palestinein particular. moreover, this paper examines the interior design of these dwellings in terms of floors, woodenfurniture fixed or movable, facilities such as bathrooms and kitchens, the distribution of furniture and its shape anddesign, furthermore, illustrate the problem that is caused by living in traditional dwellings built in ancient time,containing patterns of spatial designs that were of use in the past but no longer suit the current needs of theinhabitants and modernity. many building foundations in this paper go back to the Mamluk period, However, therest of them goes back to the Ottoman period. This paper aims to study the possibility of adapting the characteristicsand components of traditional dwellings and formulate new models and solutions that enable the inhabitants of thesedwellings to live in them while providing comfort and well-being without having to resort to the destruction andtotal removal of the internal components or replacing them with the modern style, which may not suit the aestheticsand structural feature. in addition, maintain its heritage value, by applying several measures that ensure the bestresults, within an objective analytical methodology including identifying a few selected models of traditionaldwellings, conducting a study, and inheriting it, to reach results advancing the preservation of the cultural heritageand achieving sustainability.
W. E. B. Du Bois, um exemplo de clássico
Authors: Albuquerque Ademar
Published: January 2023

Resenha do livro: DU BOIS, W. E. B. As almas do povo negro - 1° edição. São Paulo: Editora Veneta, 2021.
Modos de apropriação e produção de conhecimento na universidade
Authors: Oliveira Correa Santos Valnecy , Fabiano Campos Sulemi
Published: January 2023

Neste texto, realizamos uma abordagem acerca da escrita acadêmica, compreendida como ponto de articulação entre o linguístico e discursivo. Utilizamos como referência conceitos da Análise de Discurso, enquanto teoria e metodologia de leitura, à qual associamos os princípios do método indiciário. O corpus foi constituído por seis dissertações do Mestrado Profissional em Letras (ProfLetras), nas quais analisamos os processos de articulação de enunciados no texto, mais especificamente, arranjos sintáticos e discursivos. Com base na análise, dialogamos sobre as formas de apropriação do discurso, compreendidas como modos de dizer o dizer do outro. A leitura-escritura do corpus permitiu constituir três formas de apropriação – performativa, retórica e de conhecimento. A presença mais expressiva das duas primeiras indicou a existência, nos textos analisados, de uma escrita protocolar, em que o dizer citado se mantém distante do sujeito que cita por assimetria, sob a ideologia de que naquele está a verdade buscada por este.
Eficiencia de Trichoderma viride como un agente biocontrolador para Phytophthora capsici en Pimiento (Capsicum annuum L.)
Authors: Romero V. , Aragón L. , Casas A. , Apaza W.
Published: January 2023

Phytophthora capsici es uno de los patógenos más devastadores que limita la producción de paprika (Capsicum annuum L.) en el Mundo. Asimismo, Trichoderma destaca como agente biocontrolador por su efecto antagonista, inductor de resistencia, estimulador de crecimiento, etc. El presente trabajo evaluó la eficacia de T. viride como controlador biológico para P. capsici en páprika bajo tres métodos de siembra (directa, plantín y raíz desnuda). Se instalaron doce tratamientos bajo condiciones de invernadero, incluyendo un testigo (sin inóculo) y se empleó un diseño completamente al azar con arreglo factorial. La inoculación de T. viride se llevó a cabo a los 40 días posterior a la siembra a una concentración de 106 conidias ml-1, mientras que la inoculación de P. capsici se realizó a los 50 días posterior a la siembra empleándose tres granos de trigo colonizados por planta. El método de inoculación de T. viride en la siembra directa y plantín se hizo vía drench y en la siembra a raíz desnuda se realizó por inmersión de la plántula durante 5 minutos previo al transplante. Luego se realizó la correlación entre los métodos de siembra y P. capsici, y la interacción entre T. viride y los métodos de siembra. Los resultados mostraron que la mayor eficacia de T. viride como de P. capsici se registró en los métodos de siembra plantín y raíz desnuda; la correlación entre el método de siembra y la pudrición radicular fue menor en la siembra a raíz desnuda (74 % severidad). En los otros tratamientos (directa y plantín) el 100 % de plantas murieron; finalmente, el efecto de T. viride como inductor de crecimiento no se evidenció en ninguno de los tratamientos. Con respecto al ABCPE, el método de siembra directa mostró mayor incidencia; el menor valor de la interacción T. viride y P. capsici fue obtenido en el método de siembra raíz desnuda.
La littérature de « terrain » au service de l’enquête sur la figure auctoriale Malek et moi d’Alain Beaulieu
Authors: Pruteanu Simona Emilia
Published: January 2023

This article looks at the writing of Alain Beaulieu who, without rejecting the posture of media public writer in the era of hypermediatization of writers, remains one of the authors who continue their reflection on the role of the writer as author of fictional lives, one of whose goals could be to “fixthe world”(Gefen, 2017) the posture of auctorial-authority based on the relationship of the subject to the real in the novel by Beaulieu Maleket moi
Entre action et fiction quelle place pour la littérature face aux enjeux de demain?
Authors: Soares Mafalda Sofia Borges
Published: January 2023

The writer Aymeric Caron, a well-known figure in the general publicand now a member of the French political sphere, allows us to understand literary engagementfrom a completely new perspective. If this expression has long been associated with Sartre’s philosophy, it is clear that the dialogue between literature and the world has since been transformed. While taking a step back in the history of literary engagement in France (with the help, among others, of the works of Jean-Paul Sartre, Roland Barthes and Michel Foucault), this article proposes to understand in what way(s) a controversial author like Aymeric Caron establishes a coherent continuity between his works and his militant life. One question will accompany us throughout our reflection: can literature be both fictional and active at the same time, without losing anything of its essence?
Correlation Between History of Infectious Disease with Stunting in Toddler
Authors: Mahudeh  , Rohmah Nikmatur , Adriani Sri Wahyuni
Published: January 2023

Stunting is a chronic nutritional problem caused by a long period of malnutrition. Prolonged malnutrition can decrease body resistance, making it susceptible to disease. This study aims to analyze the correlation of the history of infectious disease with stunting cases in toddlers at the Working Area of Sumberjambe Health Center. The research design used a correlation design with a cross-sectional study approach. The sample of this research was 376 toddlers. For the sampling technique, we used stratified random sampling. The research was conducted in May 2021 using questionnaire instruments. Analyze the data using the Spearman Rho test with an α = 0.05. Result: Based on data analysis obtained from 376 respondents, 274 respondents (72.9%) experienced a history of diseases with frequent categories, and 102 respondents (27.1%) experienced a history of diseases with infrequency categories. This study concludes with a correlation between historical infectious diseases and stunting. Based on the results regarding health promotion, the prevention of recurrent or sustainable pain in toddlers needs to be improved to overcome the problem of stunting. Moreover, giving health promotion advice for mothers to provide exclusive breast milk and nutritious food and maintain food hygiene and shelter for children are essential to avoid stunting.