bluuebunny/crossref_metadata_2025 huggingface dataset:
Hubungan tingkat aktivitas fisik dengan andropause pada guru sekolah menengah atas di Kota Denpasar tahun 2022
Authors: Anak Agung Bagus Putra Indrakusuma  , Yukhi Kurniawan  , I Gusti Ngurah Pramesemara  , I Nyoman Mangku Karmaya
Published: November 2023

Introduction: Andropause is clinical syndrome due to testosterone levels reduction below normal in the body experienced by elderly men. The level of physical activity is one of the risk factors for andropause. This study aims to determine the relationship between the level of physical activity and andropause in high school teachers in Denpasar City.
Methods: This study is an observational analysis with a cross-sectional approach. Andropause was assessed using the ADAM questionnaire consisting of 10 questions. Meanwhile, the level of physical activity assessed using the GPAQ questionnaire consisting of 16 questions. The sampling technique used is purposive sampling.
Results: Total 50 respondents include in this study. As many as 66% of respondents have low levels of physical activity, 26% moderate physical activity, and 4% high physical activity. A total of 32 (64.0%) respondents experienced andropause and 18 (36.0%) did not experience andropause. There was a significant association between low levels of physical activity and andropause (p=0,05). The odds ratio (OR 95%CI) between andropause with low levels of physical activity is 11,14 (1,0 – 124,33).
Conclusion: The lower level of physical activity teachers at Denpasar City Senior High School, the higher risk of experiencing andropause. This research is expected to motivate and educate men to be more aware of andropause and keep physically active.
 
Pendahuluan: Andropause adalah sindrom klinis akibat penurunan kadar testosteron di bawah normal dalam tubuh yang dialami oleh pria lanjut usia. Tingkat aktivitas fisik menjadi salah satu faktor risiko terhadap andropause. Penelitian ini bertujuan untuk mengetahui hubungan tingkat aktivitas fisik dengan andropause pada guru SMA di Kota Denpasar.
Metode: Penelitian ini merupakan analisis observasional dengan pendekatan cross-sectional. Andropause dinilai menggunakan kuesioner ADAM yang terdiri dari 10 buah pertanyaan. Sementara itu, tingkat aktivitas fisik dinilai menggunakan kuesioner GPAQ yang terdiri dari 16 buah pertanyaan. Teknik pengambilan sampel yang digunakan adalah purposive sampling.
Hasil: Responden dalam penelitian ini berjumlah 50 orang. Sebanyak 66% responden memiliki tingkat aktivtas fisik yang rendah, 26% aktivitas fisik sedang, dan 4% aktivitas fisik tinggi. Sebanyak 32 (64,0%) responden mengalami andropause dan 18 (36,0%) tidak mengalami andropause. Terdapat hubungan yang signifikan antara tingkat aktivitas fisik rendah dengan andropause (p = 0,05). Adapun nilai odd ratio (OR 95%CI) antara andropause dengan tingkat aktivitas fisik rendah adalah 11,14 (1,0 – 124,33).
Simpulan: Semakin rendah tingkat aktivitas fisik guru di SMA Kota Denpasar, maka semakin tinggi risiko mengalami andropause. Penelitian ini diharapkan dapat memotivasi dan mengedukasi pria untuk lebih waspada terhadap andropause serta menjaga fisiknya tetap aktif.
The prognostic role of NLR, PLR, and LMR in predicting mortality of COVID-19 patients in a rural area
Authors: Cempakadewi Ade Ajeng , Budihardja Brigitta Marcia , Chundiawan Carissa Cornelia , Badu Apolonia Berenika , Ake Anselmus , Bidani Gusti Ayu Sri
Published: November 2023

Introduction: COVID-19 has been a challenge worldwide. This infection can manifest in various characteristics, from asymptomatic to severe, leading to mortality. Predictive tools to predict mortality are highly important in better therapeutic strategies. Hematology ratios, including neutrophil, platelet, lymphocyte, and monocyte, have been suggested as a prognostic tool that is widely available. The study aimed to assess the prognostic significance of NLR, PLR, and LMR in predicting COVID-19 patients' mortality in a rural setting.
Methods: Hospitalized patients with COVID-19 at Bajawa Regional General Hospital were included in this retrospective cohort study. The patient's medical records from January 2021 to August 2021 were examined. The patients were separated into two groups; in-hospital death and discharged group. The routine blood examination during admission gave NLR, PLR, and LMR results. Data analysis was processed with SPSS 26. The Receiver Operating Characteristic (ROC) curve is used to determine whether NLR, PLR, and LMR may be used as prognostic indicators for hospitalized patients’ outcomes. The area under the curve (AUC) results were used to rate the accuracy.
Results: There were 91 patients in total. NLR, PLR, and LMR, AUCs were 0.689, 0.635, and 0.653, with cut-off values of 4.28, 184.12, and 2.69, respectively. Each indicator’s sensitivity and specificity remained poor. The cut-off value of PLR was the only indicator that had significant differences when compared between the two groups. 
Conclusion: NLR, PLR, and LMR performed poor values as predictors of mortality in hospitalized patients with COVID-19.
Hubungan andropause dengan alopesia androgenik pada aparatur sipil negara di Pusat Pemerintahan Kabupaten Badung tahun 2022
Authors: Anak Agung Ayu Ratih Andira Putri  , Yukhi Kurniawan  , I Gusti Ngurah Pramesemara  , I Nyoman Mangku Karmaya
Published: November 2023

Introduction: Andropause is a collection of clinical symptoms due to a decrease in testosterone levels below normal limits. Androgenic alopecia is baldness caused by the susceptibility of the follicles to androgen hormones. The aims of study is determining the relationship between androgenic alopecia and andropause in civil servants at the Badung Regency Government Center.
Methods: The study design is cross-sectional with descriptive analytic. ADAM questionnaire is used to assessed andropause. Meanwhile, Norwood-Hamilton baldness scale is used to assessed androgenic alopecia.
Results:  Respondents in this study amounted to 40 people. A total of 27 (67.5%) positive andropause respondents and 13 respondents (33.5%) negative andropause. Meanwhile, 21 respondents (52.1%) were positive for androgenic alopecia and 19 respondents (47.5%) were negative for androgenic alopecia. There was a significant relationship (p<0.001) between andropause and androgenic alopecia. The odd ratio value (OR 95%CI) between andropause and androgenic alopecia is 34.3 (3.726-313.837).
Conclusion: Andropause has a significant relationship to androgenic alopecia of civil servants at the Badung Regency Government Center.
 
Pendahuluan: Andropause adalah kumpulan gejala klinis akibat kadar testosteron yang menurun di bawah batas normal. Alopesia androgenik adalah kebotakan yang disebabkan kerentanan folikel terhadap hormon androgen. Tujuan penelitian adalah menganalisis hubungan andropause dengan alopesia androgenik pada aparatur sipil negara di Pusat Pemerintahan Kabupaten Badung.
Metode: Rancangan penelitian adalah cross-sectional dengan deskriptif analitik. Kuesioner ADAM digunakan untuk menilai andropause dinilai. Sedangkan, alopesia androgenik dinilai dengan menggunakan skala kebotakan Norwood-Hamilton.
Hasil: Responden dalam penelitian ini berjumlah 40 orang. Sebanyak 27 (67,5%) responden positif andropause dan 13 responden (33,5%) negatif andropause. Sementara itu, 21 responden (52,1%) positif alopesia androgenik dan 19 responden (47,5%) negatif alopesia androgenik. Terdapat hubungan yang signifikan (p<0,001) antara andropause dan alopesia androgenik. Adapun nilai odd ratio (OR 95%CI) antara andropause dan alopesia androgenik adalah 34,3 (3,726-313,837).
Simpulan: Andropause memiliki hubungan signifikan terhadap alopesia androgenik pada aparatur sipil negara di Pusat Pemerintahan Kabupaten Badung.
The predictive model of acute heart failure rehospitalization: A retrospective study in Prof. I.G.N.G Ngoerah Hospital
Authors: Nyoman Ririn Chandrika Sari  , Hendy Wirawan  , Rani Paramitha Iswari Maliawan  , IGN Putra Gunadhi
Published: November 2023

Introduction. Heart failure is one of the main causes of cardiovascular morbidity and mortality. Research stated that heart failure patients who have undergone 3 rehospitalizations have a survival rate of <50% within 1 year. Therefore, the purpose of this study is to characterize the risk factors that contribute to the occurrence of heart failure rehospitalization.
Method. This is a retrospective analysis of 113 patients with a first hospitalization for heart failure at Prof. I.G.N.G. Ngoerah Hospital between July 2018–February 2020. We collected and compared demographic data, clinical findings, electrocardiogram, laboratory, and echocardiography parameters during the first hospitalization between rehospitalized and non-rehospitalized patients. Rehospitalization was defined as recurrent hospital admission due to worsening heart failure symptoms. Patients were followed for rehospitalization events until death or November 2021.
Results. The rehospitalization rate in this study was 62.8% during a median follow-up of 234 days (12–1098 days). The average of heart failure rehospitalizations during follow-up was 1.73 times (±1.97), with an average length of stay of 6.40 days (±3.27 days). We discovered that the presence of mid/apical rales at admission (odds ratio [OR] 3.509; p=0.027), hyponatremia (<135 mmol/L) at pre-discharge (odds ratio [OR] 3.840; p=0.015), and tricuspid annular plane systolic excursion (TAPSE) values <1.80 cm (odds ratio [OR] 2.905; p=0.020) were independent risk factors for rehospitalization due to worsening heart failure symptoms. Patients with these three independent risk factors have a probability of 96.24% being readmitted.
Conclusion. Mid/apical rales at admission, hyponatremia at pre-discharge, and TAPSE values <1.80 cm in patients admitted for heart failure are associated with further rehospitalization.
The association of comorbidities with mortality and severity among children with COVID-19
Authors: Riani Ni Made Dwi Angga , Purniti Ni Putu Siadi , Subanada Ida Bagus
Published: November 2023

Background: Several case series have described the clinical characteristics of COVID-19 in pediatric patients and suggest milder illness severity in children compared with adults. However, some cases presented more severe diseases with small numbers of deaths have been documented. Some studies in developed countries demonstrated that the presence of comorbidities among COVID-19 patients could increase the severity of the disease. Therefore, this study aimed to identify the association of comorbidities with mortality and severity among children with COVID-19.
Methods: This was an analytic retrospective cross-sectional study conducted in Prof. Dr. IGNG Ngoerah Hospital, Denpasar, from May 2020 until March 2022. A total of 94 children aged 28 days-18 years old with confirmed COVID-19 were included in this study and divided into two groups, with comorbidities and without comorbidities. The chi-square test was used to determine the association between comorbidities and their relation to mortality and severity. The statistical significance was set at p less than 0.05.
Results: The normality test showed that the age data distribution is not normal with the median age of 72 months (IQR 45-189) and 108 months (IQR 64-240) in the comorbidities and without comorbidities group, respectively. Bivariate analysis showed there was a significant association between comorbidities with the mortality and severity among children with COVID-19 (PR 3.21; 95% CI 1.04-9.90; p= 0.036) and (PR 10.71; 95%CI 4.12-27.83; p< 0.001), respectively. The multivariate analysis revealed the comorbidities increased risk of mortality and severity with adjusted OR (aOR) 3.74 (95%CI 1.14-12.25) and adjusted OR (aOR) 11.8 (95%CI 4.35-32.41), respectively; after adjusting for  age and nutritional status.
Conclusion: Comorbidities significantly affect mortality and severity among children with COVID-19.
Acute kidney injury in a covid-19 patient with Non-ST elevation myocardial infarction: case report
Authors: Rihi Pake Indry Agatha , Putri Putu Eka Dianti , Suwirya Agung Pradnyana , Lestari Desak Nyoman Desy
Published: November 2023

Introduction: Coronavirus disease 2019 (COVID-19) has a variety of manifestations, from asymptomatic to acute illness that can affect several organs, although being primarily associated with the respiratory system. The virus binds to angiotensin-converting enzyme-2 (ACE-2) receptors in humans and the expression of ACE-2 in heart and kidneys explains the association of COVID-19 with the renal and cardiovascular systems.
Case description: Male, 62-year-old, was admitted to the emergency room (ER) for presented shortness of breath, angina pain, and gastric pain. He was a smoker and denied having comorbidities. At arrival, an examination of vital signs and physical showed tachypnea, tachycardia, hypertension, and bilateral crackles. The electrocardiography (ECG) showed left ventricular hypertrophy and Non-ST-Elevation in anterolateral. The chest x-ray showed pneumonia and cardiomegaly. Laboratory findings showed that decreased renal function and Polymerase Chain Reaction (PCR) test was positive, and increased in serum Troponin level supported the diagnosis of Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-Cov-2) pneumonia with Non-ST elevation myocardial infarct (NSTEMI) and Acute Kidney Injury (AKI). Loading of Aspilet, Clopidogrel, Atorvastatin, and Thrombolysis with Fondaparinux was done. The following day, transthoracic echocardiography was performed anterolateral regional wall motion abnormality with 43% of Left Ventricle Ejection Fraction (LVEF). Two weeks after hospital discharge, the echocardiography evaluation showed no improvement and was diagnosed with Chronic Heart Failure with New York Heart Association (NYHA) Functional Classification II et causa Coronary Artery Disease.
Conclusion: Treatment of covid-19 patients with cardiovascular and renal complications is quite challenging since there is no specific guideline for COVID-19 patients with renal and cardiovascular complications.
Autologous Serum Eye Drops (ASEDs) as dry eye disease treatment option
Authors: Anak Agung Ayu Putri Oktiadewi  , I Putu Rustama Putra
Published: November 2023

Background: Nowadays, there are a lot of treatment options available for dry eye syndrome (DES) or disease (DED). Autologous Serum Eye Drops (ASEDs) is one of the options that offer a potential advantage over conventional therapy. Biochemical elements in ASEDs resemble real tears and act as a lacrimal substitute to provide lubrication. As a severe dry eye treatment, using ASEDs has grown in favor.
Aim: This review aims to deliver knowledge from the current literature on applying ASEDs for dry eye disease in the medical worker.
Method: The method used was a literature review. A comprehensive search was performed on Pubmed and Google Scholar databases in December 2022 using each of the following keywords “ASEDs”, “serum”, “eyedrop”, “DED” and “DES”.
Conclusion: Dry eye disease is incurable and symptom management is the focus of therapy.     Studies have shown that ASEDs reduced dry eye symptoms in over 60% of patients by inhibiting the release of inflammatory cytokines and increasing the number of goblet cells and mucin expression in the conjunctiva. The serum eye drop is typically well tolerated and can be one of the best treatment options for severe DED due to its close resemblance to tears, preservatives free and minimum side effects.
Hubungan antara riwayat hipersensitivitas dan kadar imunoglobulin e (IgE) total serum dengan sindrom koroner akut di unit pelayanan jantung terpadu RSUP sanglah denpasar
Authors: Mataram Kadek Wisnu , Suryana Ketut , Aryadana Wayan
Published: November 2023

Background: Currently, mast cells are implicated in the pathogenesis of coronary heart disease. Mast cells are the only cell tissue that expresses on the surface of the high affinity receptor for IgE (FCεR) and synthesizes vasoactive, spasmogenic, fibrogenic factors and can damage the connective tissue covering the atheroma plaque so that the plaque is prone to rupture. The aim of this study was to determine the relationship between a history of hypersensitivity and total serum IgE levels with acute coronary syndrome.
Methods: This study was an analytic cross-sectional study to determine the relationship between history of hypersensitivity and total serum IgE levels with acute coronary syndrome. The study was conducted at the Integrated Cardiac Service Unit Sanglah Hospital Denpasar with consecutive sampling according to the inclusion and exclusion criteria of 68 samples.
Results: The results of the history of hypersensitivity analysis with ACS obtained a p value of 0.685; OR 0.778. Analysis of the relationship between total serum IgE levels and ACS resulted in a p value of 0.000; OR 10.385, a history of hypersensitivity with IMA obtained a p value of 0.187; OR 0.281 and total IgE levels with IMA obtained a p value of 0.584; OR 0.273.
Conclusion: There is a relationship between total serum Immunoglobulin E (IgE) levels with acute coronary syndrome and MI. There is no relationship between history of hypersensitivity with acute coronary syndrome or MI.
 
Latar Belakang: Saat ini, sel mast diimplikasikan dalam patogenesis dari penyakit jantung koroner. Sel mast merupakan satu-satunya jaringan sel yang ekpresinya pada permukaan high affinity receptor untuk IgE (FCεR) dan mensintesis faktor vasoaktif, spasmogenik , fibrogenik dan dapat merusak jaringan ikat yang menutupi plak atheroma sehingga plak rentan pecah. Tujuan Penelitian ini untuk mengetahui hubungan antara riwayat hipersensitivitas dan kadar IgE total serum dengan sindrom koroner akut.
Metode: Penelitian ini merupakan penelitian dengan rancangan potong lintang analitik untuk mengetahui hubungan antara riwayat hipersensitivitas dan kadar IgE total serum dengan sindrom koroner akut. Penelitian dilakukan di Unit Pelayanan Jantung Terpadu RSUP Sanglah Denpasar dengan consecutive sampling sesuai kriteria inklusi dan eksklusi sebesar 68 sampel.
Hasil: Hasil analisis riwayat hipersensitivitas dengan SKA didapatkan nilai p 0,685; OR 0,778. Analisis hubungan antara kadar IgE total serum drngan SKA didapatkan hasil nilai p 0,000; OR 10,385, riwayat hipersensitivitas dengan IMA didapatkan nilai p 0,187;OR 0,281 serta kadar IgE total dengan IMA didapatkan hasil nilai p 0,584; OR 0,273.
Simpulan: Terdapat hubungan antara kadar Immunoglobulin E (IgE) total serum dengan sindrom koroner akut dengan IMA. Tidak terdapat hubungan antara riwayat hipersensitivitas dengan sindom koroner akut maupun IMA.
Tatalaksana kasus trombosis vena dalam iliofemoral akut dengan sistem trombektomi aspirasi mekanik Indigo CAT8
Authors: Wiradana Anak Agung Gde Agung Anom Arie , Wibawa I Gusti Agung Bagus Krisna , Budiarta Ida Bagus
Published: November 2023

Introduction: Acute deep vein thrombosis is a common cause of morbidity and mortality. Venous thrombosis commonly involves the lower extremities, including the iliac veins, femoral veins and vena cava. Optimal therapy of deep vein thrombosis, both ileofemoral and central can prevent complications.
Case Presentation: A 51 years old man complained of swelling of his right leg accompanied by acute pain. On duplex ultrasonography examination, there was a venous thrombosis in the iliofemoral area descending from the common iliac vein to the deep femoral vein. Endovascular venous mechanical thrombectomy was immediately performed because the symptoms were acute, and signs of swelling and pain intensity did not improve. An 8-F catheter was inserted into the patient's right distal superficial femoral vein under ultrasound guidance after administration of intravenous heparin. The CAT8 was inserted through the 8-F sheath and found the thrombus, then vacuum thrombectomy was performed. Swelling and pain disappeared a few hours after the procedure, and the patient was discharged 2 days later.
Conclusion: The Indigo CAT 8 mechanical aspiration thrombectomy system can be an effective treatment modality for patients with acute iliofemoral or central deep vein thrombosis.
 
Latar Belakang: Trombosis vena dalam akut adalah penyebab umum morbiditas dan mortalitas. Trombosis vena umumnya melibatkan ekstremitas bawah, termasuk vena iliaka, vena femoralis, dan vena cava. Terapi optimal trombosis vena dalam, baik ileofemoral maupun sentral dapat mencegah komplikasi.
Presentasi Kasus: Seorang laki-laki 51 tahun mengeluh kaki kanan bengkak disertai nyeri akut. Pada pemeriksaan ultrasonografi dupleks, terdapat trombosis vena di daerah iliofemoral turun dari vena iliaka komunis ke vena femoralis dalam. Trombektomi mekanik vena endovaskular segera dilakukan karena gejalanya akut, dan tanda pembengkakan serta intensitas nyeri tidak membaik. Kateter 8-F dimasukkan ke dalam vena femoralis superfisial distal kanan pasien di bawah panduan ultrasonografi setelah pemberian heparin intravena. Kateter CAT8 dimasukkan melalui selubung 8-F dan ditemukan trombus, kemudian dilakukan trombektomi vakum. Bengkak dan nyeri menghilang beberapa jam setelah prosedur, dan pasien dipulangkan 2 hari kemudian.
Simpulan: Sistem trombektomi aspirasi mekanik Indigo CAT 8 dapat menjadi modalitas pengobatan yang efektif untuk pasien dengan trombosis vena dalam sentral atau iliofemoral akut.
Omicron tidak meningkatkan Neutrophil to Lymphocyte Ratio (NLR) di Rumah Sakit Darurat Covid-19 (RSDC) Wisma Atlet Kemayoran: studi pendahuluan
Authors: Amelia Winda , Lee Jemimah Kezia , Karina Silvia Yanita , Sidharta Karolin Dwi Setiowati
Published: November 2023

Background: Neutrophil Lymphocyte Ratio (NLR), which is the sum of neutrophils divided by lymphocytes, has an important role in determining the inflammatory state in the patient. RNL is one of the markers of inflammation that is simple, rapid, and can be performed on routine blood tests.
Methods: This research is a retrospective descriptive study that examined NLR levels in patients confirmed with the Omicron variant of COVID-19 infection at the Wisma Atlet COVID-19 Hospital, Kemayoran, Jakarta. Data were analyzed using SPSS version 20.0 for Windows.
Results: From 331 samples, 187 samples were found to be female and 144 samples were male. A total of 300 samples had no increase in NLR (NLR <3.13), while the other 31 samples had an increase in NLR (NLR >3.13). Cytokine storm associated with immune dysregulation occurs less in women than in men. Almost all patients with confirmed Omicron variant COVID-19 at the Wisma Atlet Kemayoran Hospital did not experience an increase in NLR.
Conclusion: The cytokine storm associated with immune dysregulation occurs less frequently in women than in men. Almost all patients confirmed with the Omicron variant of COVID-19 at Wisma Atlet Hospital Kemayoran did not experience an increase in NLR.
 
Latar Belakang: Rasio Limfosit Neutrofil (RNL), yang merupakan jumlah neutrofil dibagi dengan limfosit, memiliki peran penting dalam menentukan keadaan inflamasi pada pasien. RNL merupakan salah satu penanda inflamasi yang sederhana, cepat, dan dapat dilakukan pada pemeriksaan darah rutin.
Metode: Penelitian ini merupakan studi deskriptif retrospektif yang meneliti kadar RNL pada pasien terkonfirmasi infeksi COVID-19 varian Omicron di Rumah Sakit COVID-19 Wisma Atlet, Kemayoran, Jakarta. Data dianalisis dengan SPSS versi 20.0 untuk Windows.
Hasil: Dari 331 sampel, ditemukan 187 sampel berjenis kelamin perempuan dan 144 sampel berjenis kelamin laki-laki. Sebanyak 300 sampel tidak mengalami peningkatan NLR (NLR <3,13), sedangkan 31 sampel lainnya mengalami peningkatan NLR (NLR >3,13). Badai sitokin yang terkait dengan disregulasi imun terjadi lebih sedikit pada wanita dibandingkan pada pria. Hampir seluruh pasien terkonfirmasi varian Omicron COVID-19 di RS Wisma Atlet Kemayoran tidak mengalami peningkatan NLR.
Simpulan: Badai sitokin terkait dengan disregulasi imun, terjadi lebih sedikit pada wanita dibandingkan dengan laki-laki.hampir seluruh pasien terkonfirmasi COVID-19 varian Omicron di RSDC Wisma Atlet Kemayoran tidak mengalami peningkatan RNL.
Effect Sacubitril/Valsartan in patients with Acute Myocardial Infarction (AMI): a systematic review and meta-analysis
Authors: Pratistha Fernanda Savitri Mega , Ardiana I Wayan Surya
Published: November 2023

Background: Acute Myocardial Infarction (AMI) is a type of coronary heart disease with high morbidity and mortality. The renin-angiotensin-aldosterone system (RAAS) is an important endocrine system in controlling blood pressure and cardiovascular homeostasis and is responsible for AMI. In patients with AMI or a heart attack, sacubitril/valsartan has been shown to reduce the risk of heart failure and death. This study aims to evaluate the effect of sacubitril/valsartan in AMI patients.
Methods: In order to evaluate the effects of sacubitril/valsartan in patients with AMI, three databases, including PubMed, Cochrane Library, and the ClinicalTrials website, were searched. The final search was performed in January 2023. The meta‑analysis was subsequently performed with Revman 5.4 software and a total of three studies were included.
Results: The results of the main outcomes showed that sacubitril/valsartan has no significant reduction in major adverse cardiovascular and cerebrovascular events (MACCEs) odds ratio (OR), 0.70; 95% confidence interval (CI), 0.38‑1.30; P=0.26] and incidence of acute heart failure (AHF) (OR, 0.52; 95% CI, 0.24‑1.15; P=0.11). The secondary outcomes showed no effect of sacubitril/valsartan to increase left ventricular remodeling.
Conclusion: In conclusion, the present meta‑analysis revealed that sacubitril/valsartan could not effectively reduce the incidence of MACCEs and AHF in patients with AMI. In the future, a meta‑analysis study will be designed with many studies to reduce the incidence of MACCEs and AHF effectively.
Clinical profile of patients with pseudoexfoliation glaucoma in Bali Mandara Eye Hospital from January to December 2022: a descriptive retrospective Study
Authors: Natan Priscilla Christina , Yinvill  , Rahayu Ni Kompyang
Published: November 2023

Background: Pseudoexfoliative glaucoma (PEX glaucoma) is a type of secondary either open or closed-angle glaucoma that is characterized by the accumulation of flaky, whitish material on the surface of the eye. This material, known as pseudoexfoliative material (PEX), can clog the eye's drainage system, leading to increased intraocular pressure and eventual optic nerve damage if left untreated. This study aimed to describe the characteristic and management of PEXG in the Bali Mandara Eye Hospital Denpasar.
Methods: A descriptive retrospective study was conducted in March-April 2023 using electronic medical records of PEXG patients in the Bali Mandara Eye Hospital Denpasar from January–December 2022.
Results: There were 26 patients (37 eyes) diagnosed as PEXG; most of them were male (88.4%), aged 60-69 years old (34.4%), and followed by those in the range of age 70–79 years old (42.3%). Most of the cases were bilateral (59.5%) with a decrease of visual acuity of less than 3/60 (54%), an increase of intraocular pressure (IOP) with the majority in the range of 20-29 mmHg (35.1%), and 10-19 mmHg (29.8%), and followed by those who have a history of metabolic disease with Hypertension found on ten patients (38.4%) and Diabetes Mellitus on three patients (11.5%). The treatment combined several types of antiglaucoma medication and glaucoma surgery with patients who had undergone surgery in 19 eyes (51.3%). And the  post-operative visual acuity was measured and showed the most favorable results, with normal eyes found in 14 eyes  (73.6%).
Conclusion: PEX Glaucoma is commonly found in elderly patients. At the same time, most patients come with high IOP and late stage of the disease. The most frequent treatment is triple procedure surgery which produces a significant visual acuity improvement.
Incidence and outcomes of persistent pulmonary hypertension of the newborn in a tertiary referral center, Indonesia
Authors: Fernandez Maria Angela Yustina , Eka Gunawijaya  , Ni Putu Veny Kartika Yantie  , Made Sukmawati
Published: November 2023

Background: Persistent pulmonary hypertension of the newborn (PPHN), also known as persistent fetal circulation, is a failure of the transition/adaptation process from fetal to extrauterine life with significant morbidity and mortality rates. This study determined the incidence and outcome of PPHN in infants.
Methods: From January 2017 to March 2022, an observational study was conducted on newborns with PPHN who were hospitalized in the second and third-level neonatology wards of Prof. Dr. I.G.N.G. Ngoerah Hospital. Based on a clinical and echocardiographic examination, PPHN was confirmed. Missing data on infants were excluded. PPHN incidence and outcomes were the main outcomes. The clinical profile of newborns with PPHN was one of the secondary outcomes.
Results: There were 42 neonates, with a median age of 1 (range 0-5 days) day at diagnosis. PPHN occurred in 2.5 cases per 1000 neonates admitted, with 60% male and 40% female. Referrals accounted for 74% of all PPHN cases. The majority of cases were born cesarean delivery (83%), at term (74%), and with birth weights of more than 2500 grams (65%). In 55% of cases, asphyxia history was discovered. The median oxygen index (OI) was 5.3 (range 1.90-57.30), with pneumonia/sepsis accounting for 95% of the causes. The median length of stay was 9.50 days (range 1-89), and 20 (48%) of the 42 cases had death.
Conclusion: The incidence of PPHN in a tertiary referral center in Indonesia is 2.5 cases per 1000 patients treated with a 48% mortality rate.
The impact between peritoneal closure and non-closure on the risk of adhesion in caesarean section: a systematic review
Authors: Junardi Thomas Yohan , Taura Avensia
Published: November 2023

Background: Caesarean section is one of the most frequently performed major surgical procedures worldwide. Peritoneal sutures in the cesarean section are performed via absorbable or delayed sutures. There is controversy over the choice of technique (continuous or interrupted) to close this layer, even among surgeons who believe in closing this layer. Overall, there are still differing opinions regarding the closure of this layer. This study examines how the study of the impact of peritoneal closure with no closure at the cesarean section on the risk of adhesions. Methods: Systematic Literature Review Research is the method selected by researchers in this study. Researchers will describe facts, data and information obtained from literature studies such as books and journals to research results related to the research topic. The quality of the articles was reviewed based on PRISMA and PICO guidelines so that as many as 7 articles were synthesized in the final review report from the literature.Results: It is known that the incidence of births worldwide by Caesarean section (CS) is increasing. Many births after CS have previously been performed by repeat surgery, either with elective CS or after an unsuccessful delivery attempt. The formation of these adhesions is associated with increased maternal morbidity in patients with recurrent CS. In studies, non-closure of the peritoneum appears to save time and costs and therefore lacks the adhesions that cause infertility. However, not closing the parietal peritoneum will cause adhesions without causing infertility. These adhesions can cause long operating times, recovery, and increased postoperative pain in the second cesarean section.Conclusion: Caesarean section is a very common surgical procedure worldwide. Suturing the peritoneal lining in the cesarean section can provide benefits or not. Therefore it is necessary to evaluate whether this step should be omitted.
Karakteristik tajam penglihatan, tekanan bola mata dan penyakit mata masyarakat Desa Celuk, Gianyar Provinsi Bali di era pandemi COVID 19
Authors: Ni Kadek Puspa Mega Putri Sudibia  , Ni Made Ari Suryathi  , Ni Made Suryanadi  , I Wayan Eka Sutyawan  , Ni Made Laksmi Utari  , I Gusti Ayu Ratna Suryaningrum
Published: November 2023

Background: It is an important effort to do a visual and intraocular pressure by conducting examination directly to the community due to support the Indonesian Ministry of Health to reduce the prevalence of blindness by 2030. This examination will produce epidemiological data.
Aim: To find out the characteristics of visual acuity, intraocular pressure and eye disease in the people of Celuk Village, Gianyar, Bali in the Era of Covid 19 pandemic.
Methods: Observational descriptive of the people of Celuk Village, Gianyar Regency, Bali
Results: Visual examination results in the right and left eyes were mostly normal. The results of tonometry showed that most people still have normal eye pressure. The data obtained from the examination results to the public can be used as a reference value in the normal population. Strategies that can be taken to prevent the transmission of COVID-19 during external examinations are choosing a large location, adjusting the seat distance, setting the time of patient arrival, officers must be vaccinated, antigen swabs are carried out, and use PPE.
Conclusion: In this study, the most common visual disturbance was age-related presbyopia.
 
Latar belakang: Pemeriksaan visus dan tekanan bola mata dengan turun langsung ke masyarakat sangat penting untuk dilakukan karena menunjang harapan Kemenkes RI menurunkan prevalensi kebutaaan tahun 2030. Pemeriksaan ini akan menghasilkan data epidemiologis.
Tujuan:  Untuk mengetahui karakteristik tajam penglihatan, tekanan bola mata dan penyakit mata masyarakat Desa Celuk, Gianyar Provinsi Bali di era pandemi COVID 19
Metode: Deskriptif observasional pada masyarakat Desa Celuk, Kabupaten Gianyar, Provinsi Bali.
Hasil: Visus mata kanan dan kiri sebagian besar normal. Hasil tonometri mendapatkan sebagian besar masyarakat masih memiliki tekanan bola mata normal. Data yang diperoleh dari hasil pemeriksaan tersebut ke masyarakat dapat digunakan sebagai referensi nilai normal di populasi. Strategi yang dapat dilakukan untuk pencegahan transmisi COVID-19 selama skrining dan pemeriksaan luar adalah memilih lokasi yang luas, mengatur jarak kursi tunggu, mengatur waktu kedatangan pasien, seluruh petugas wajib divaksinasi, dilakukan swab antigen, dan menggunakan APD.  
Simpulan: Pada penelitian ini gangguan penglihatan yang paling banyak adalah presbiopia terkait dengan usia.
12th Bali Cardiology Update Proceeding Abstract
Authors: Suwirya Agung
Published: November 2023

As the COVID-19 pandemic has been resolved, we are glad to welcome our colleagues to visit the paradise island, Bali, while joining our annual meeting, the 12th Bali Cardiology update that will be held offline. We organises workshops, symposiums, plenary talks, lectures with international and national keynote speakers, and interactive gatherings from throughout regions to discuss cutting-edge discoveries to advance the profession and medications specializing in cardiovascular disease managements, providing an absolutely superb framework for professionals in cardiovascular health, researchers, scientists, healthcare specialists, academicians, and individuals with interest in cardiology. This is your best opportunity to network with the most individuals from hospitals, academic institutions, heart associations, and research facilities because there are people from all over the world interested in finding a few solutions in the field of cardiology. The opportunity to network with colleagues and hear from renowned cardiologists and cardiovascular researchers at this cardiology summit is unmatched.
English teaching as gendered care work
Authors: Yang Jinsuk
Published: November 2023

Drawing on data from ethnographic fieldwork at an English language school for young learners in South Korea, this article examines the relationship between emotional labour and gender in English language teaching (ELT). It takes note of how bilingual speakers’ emotional work was constructed as suitable for women and rendered invisible in their respective working contexts. The findings show that: 1) the job requires the female bilingual teachers to not only teach English but also engage in invisible, gendered childcare; and 2) amid the paradoxical situation in which bilingual teachers are expected to reproduce the ideology of native speakerism to be recognized as proficient English speakers, their anxiety about linguistic and cultural hybridity also deepened. The precarious labour conditions of female bilingual teachers in the school epitomise a broader trend in the contemporary South Korean ELT market, where female bilingual teachers’ emotional labour is naturalised in the name of caring.
queerqueen: Linguistic excess in Japanese media. Claire Maree (2020)
Authors: Arnold-Murray Katherine
Published: November 2023

queerqueen: Linguistic Excess in Japanese MediaClaire Maree (2020)Oxford University Press, 214pp.
From Fritzl to #metoo: Twelve Years of Rape Coverage in the British Press. Alessia Tranchese (2023)
Authors: Tanquary Nicole
Published: November 2023

From Fritzl to #metoo: Twelve Years of Rape Coverage in the British PressAlessia Tranchese (2023)Palgrave Macmillan, 436pp.
Arduino-based high-frequency radio telescope and observations
Authors: Banerjee Subham , Bhaduri Saptarshi , Chandra Avinandan , Chatterjee Mayukh , Debnath Sovik , Nazneen Humaira , Sarkar Neelavra , BappadityaManna  , Roychowdhury Suparna , Banerjee Shibaji
Published: November 2023

This is a pilot project undertaken by the UG and PG students of the Department of Physics, St. Xavier's College (Autonomous), Kolkata under the supervision of Dr. Suparna Roychowd hury and Dr. Shibaji Banerjee and with the assistance of Mr. Bappaditya Manna, Technical Officerof Father
Eugene Lafont Observatory (FELO) on building a low-cost high-frequency radiotelescope using Arduino. This paper presents the design of the smallArduino-based radio telescope recently developed by the group to observe radio emission at high frequencies (12-18GHz)and the initialobservations
including detection of geostationary andnon-geostationary satellites. Preliminary results demonstrate the effectiveness of this Arduino-based radio telescope in the eraof large radio telescopes that are inaccessible to students. As the radio telescope operates in ahigh-frequency range, it
is easier to observe in city areas where Radio Frequency Interference(RFI) is a significant issue. The system can be pointed either manually or using a computerized mount to any radio source and data can be collected from a satellite finder as well asfrom Arduino micro-controller. This system
can be used for a basic understanding of radioastronomy and for training purposes for University and College students at a very lowcost. Further, we would also like to extend this to a two-element radio interferometer andundertake interferometric observations of astronomical radio sources
in future.
Sindrome do intestino irritável pós-COVID-19: uma revisão integrativa
Authors: Silva Julyanne Tereza Cordeiro , Fonseca Neto Olival Cirilo Lucena da
Published: November 2023

RESUMO Introdução: a persistência de sintomas a longo prazo da COVID-19 representa um novo desafio à comunidade médico-científica, é a condição denominada COVID-19 longo. A Síndrome do Intestino Irritável (SII) é um dos Distúrbios da Interação Intestino Cérebro mais comuns e seu desenvolvimento pós-infecção já é validado. Segundo os critérios de Roma IV, caracteriza-se por presença de dor abdominal recorrente, em média, pelo menos 1 dia por semana nos últimos 3 meses com início dos sintomas pelo menos 6 meses antes do diagnóstico, associada a 2 ou mais fatores: relacionada à defecação e/ou associada com mudança na frequência das fezes e/ou associada com mudança na forma das fezes. Este estudo teve como objetivo revisar dados acerca de SII pós-COVID-19. Métodos: trata-se de uma Revisão Integrativa de estudos publicados entre 1º de janeiro de 2020 a 30 de abril de 2023, que apresentassem dados acerca de SII com a doença COVID-19 previamente diagnosticada. Utilizou-se a base de dados PubMed, os descritores foram “Irritable bowel syndrome” AND “COVID-19”; a lista de referência dos artigos também foi recuperada. Resultados: oito estudos foram revisados, observou-se que 0,6% a 11,6% pacientes cursaram com SII de novo após um período mínimo de 6 meses da infecção. Os fatores de risco foram sexo feminino, gravidade da COVID-19, presença de sintomas gastrointestinais de fase aguda e depressão/ansiedade. Conclusão: os resultados obtidos permitem crer que a COVID-19 pode estar associada ao surgimento de SII de novo. São necessários outros estudos para investigar seus efeitos a longo prazo e espectros clínicos..
ANALYZING COURSE PEDAGOGIC PROJECTS: GENDER AND SEXUALITY IN TEACHER EDUCATION
Authors: GUIMARÃES EDUARDO BARBOSA DE MENEZES , SILVA IOLETE RIBEIRO DA , FERREIRA ISABEL CRISTINA FERNANDES , ESPERANÇA ANGELO CABRAL
Published: November 2023

ABSTRACT: The school space is uncomfortable for dissident sexual and gender performances and identities. It is common to find teachers who reproduce LGBTI+phobic violence and those who recognize their inability to deal with this issue, demonstrating an intention to deconstruct paradigms by seeking to transform their pedagogical practices. In this sense, this article aims to identify whether and how gender and sexuality are present in ten 'course pedagogical projects' (CPP) of teacher training undergraduate degrees in two public universities in Manaus, Brazil. We carried out documental research, using constructive-interpretative data analysis from a historical-cultural perspective. The results point out the little presence of the theme in the courses' design and subjects' syllabi. Discussions on gender and sexuality occur in specific activities but not transversally throughout the undergraduate course. When discussions explicitly take place, they are grounded on a biological discourse, and the theme is not concretely established in the CPPs. This work contributes to reflecting on the importance of pre-service teachers discussing gender and sexuality. It indicates the need for a pre-and in-service education aimed to deconstruct cis heteronormativity as an alternative to overcome the prejudice that interferes with the know-how in/of school as a welcoming space, open for careful listening, inclusion, and equity, which are essential to a humanizing and emancipatory education.
Gas exchange and osmotic adjustment in cotton cultivars subjected to severe salt stress
Authors: Marcelino A. D. A. de L. , Barbosa D. D. , Fernandes P. D. , da Silva F. de A. , de Albuquerque F. A. , Dias M. dos S. , da Silva C. R. C. , dos Santos R. C.
Published: November 2023

Abstract Salinity is harmful to crops when the concentration of soluble salts overcomes the salinity threshold of the crop, causing osmotic stress and limitations in plant growth. In this scenario, adopting tolerant cultivars is the most adequate strategy to minimize agricultural losses. However, the inheritance of tolerance depends on the genotype. From this perspective, this study assessed the tolerance to severe salt stress in 11 cotton cultivars based on gas exchange parameters and the free proline content. The cultivars were grown in a greenhouse and subjected to 34 days of saline irrigation (10 dS m-1), starting 45 days after seedling emergence (B1 phase). Plant growth was monitored weekly until the end of the salt stress period. The treatments consisted of a combination of two factors: eleven cultivars associated with two electrical conductivity levels of irrigation water (ECw: 0.3 and 10.0 dS m-1). The experimental design was in randomized blocks in a 11 × 2 factorial arrangement with three replications (66 plots), with the experimental unit consisting of one plant per plot. Salinity impacted plant growth, being reflected on the gas exchange and free proline data of most cultivars. However, BRS 286, FMT 705, BRS 416, and BRS Acácia, and CNPA 7MH withstood the effects of stress and osmotically adjusted to the salt stress conditions, thus minimizing the damage to growth. Those cultivars are the most indicated for improvement programs aiming at tolerance to salt stress based on the results found in this research.
Maturation and harvest time of Ateleia glazioveana Baill. seeds
Authors: Carvalho G. A. , Lima P. A. M. , Carvalho M. A. , Lopes S. O. , Jacomino G. R. L. , Costa J. S. , Simões I. M. , Mello T. , Almeida T. F. R. , Mengarda L. H. G. , Alexandre R. S. , Lopes J. C.
Published: November 2023

Abstract Ateleia glazioveana Baill. is a pioneer, rustic and can be used for forest recovery. This work aimed to study the process of physiological maturation of this species. The research was carried out in the city of Alegre - ES, the trees were identified in the floral anthesis and accompanied during the filling of the fruits and development of the seeds until the complete maturation. The fruits were harvested at the following stages 7, 14, 21, 28, 35 and 42 days after anthesis, and characterized according to: morphometry, moisture, fresh and dry mass of fruits and seeds, germination, germination speed index, shoot and root length and dry mass of seedlings. The regression equations were adjusted for the main characteristics analyzed as a function of the harvest period. The point of physiological maturity of timbó occurred at 42 days after anthesis.
Ecophysiological mechanisms and growth of Inga vera Willd. under different water and light availability
Authors: Cerqueira W. M. , Scalon S. P. Q. , Santos C. C. , Santiago E. F. , Almeida J. L. C. S. , Figueiredo V. M. A. , Linné J. A. , Silverio J. M.
Published: November 2023

Abstract Light and water availability can impact plant survival and growth, making ecophysiological studies crucial for understanding their tolerance and to single and combined stresses. The aimed of this study was to investigate the physiological and growth responses of Inga vera Willd. plants induced by different water regimes and light intensities. Three water regimes were implemented based on substrate water retention capacity (WRC) - 50%, 75%, and 100%, along with shading levels (SH) - 0% (full sun), 30%, and 70%. Evaluations were conducted at 25 and 50 days after applying the water regimes, and during a recovery period of 30 days when all treatments were maintained at 75% of WRC. Photochemical efficiency, gas exchange, chlorophylls indices, growth, quality of the seedlings and content proline amino acid were assessed. Overall, I. vera plants showed greater sensitivity to increased exposure to light than to low water availability. The interaction of SH + WRC was beneficial for the gas exchange and chlorophylls indices characteristics under SH 70% + WRC 75-100% at 25 and 50 days, with higher results, greater plant growth and higher proline contents for leaves and roots under SH 30% and 70% + WRC 50%, 75% and 100% at 25 and 50 days. There was no recovery effect for seedlings grown in full sun. The plants grown under shade during the recovery period maintained their values for most of the characteristics evaluated. SH 30% + WRC 75% contributed to an increase in photosynthetic metabolism and, as a result, to the quality of the seedlings.