bluuebunny/crossref_metadata_2025 huggingface dataset:
CROCIN PROMOTES APOPTOSIS IN HUMAN EBV-TRANSFORMED B-LYMPHOCYTE VIA INTRINSIC PATHWAY
Authors: Sotoodeh Jahromi Abdolreza , Kargar Mohammad , Kafilzadeh Farshid , Jamalidoust Marzieh , Moradzadeh Maliheh
Published: June 2021

Background: As a major carotenoid in saffron, crocin demonstrates potent anti-cancer impacts. However, its anti-lymphoma effects remain vague, especially in the human EBV-associated B-cell lymphoproliferative disorders. This study examined crocin's apoptogenic potential and its underlying mechanism in CO 88BV59-1 cell line vs. normal human peripheral blood B cells.
Methods: CO 88BV59-1 cells were treated with crocin alone or in combination with vincristine for up to 72 h. The cell viability was examined using a resazurin assay. Flow cytometry using annexin V and propidium iodide labeling was performed to detect apoptotic cells. Also, the expression levels of genes and proteins involved in apoptosis (CASP3, CASP8, CASP9, P53, Bax, and Bcl-2) were respectively determined via real-time PCR and Western blot analysis.
Results: Crocin concentration-dependently reduced cell viability in CO 88BV59-1 cells with no significant toxicity toward normal B cells. Similar to vincristine, crocin significantly increased apoptosis in these cells during 72 h of incubation. Furthermore, the combination of crocin (80 μM) and vincristine (1 μM) enhanced apoptosis in CO 88BV59-1 cells. Therefore, this synergistic effect was detected in human EBV-transformed B-lymphocyte. CASP3, CASP9, P53, and Bax/Bcl-2 ratio expressions were significantly raised in CO 88BV59-1 cells, whereas CASP8 was unaltered. It was proposed that crocin promoted apoptosis in CO 88BV59-1 cells in a time- and concentration-dependent manner via the induction of the intrinsic pathway.
Conclusion: The results suggest that crocin may serve as a good alternative/coadjuvant to vincristine in EBV-associated B-cell lymphoproliferative disorders.
Keywords: Crocin, CO 88BV59-1 cells, EBV-associated B-cell lymphoproliferative disorders, apoptosis
Brown Fat as a Regulator of Systemic Metabolism beyond Thermogenesis
Authors: Yuko Okamatsu-Ogura , Saito Masayuki
Published: June 2021

Brown adipose tissue (BAT) is a specialized tissue for nonshivering thermogenesis to dissipate energy as heat. Although BAT research has long been limited mostly in small rodents, the rediscovery of metabolically active BAT in adult humans has dramatically promoted the translational studies on BAT in health and diseases. Moreover, several remarkable advancements have been made in brown fat biology over the past decade: The molecular and functional analyses of inducible thermogenic adipocytes (socalled beige adipocytes) arising from a developmentally different lineage from classical brown adipocytes have been accelerated. In addition to a well-established thermogenic activity of uncoupling protein 1 (UCP1), several alternative thermogenic mechanisms have been discovered, particularly in beige adipocytes. It has become clear that BAT influences other peripheral tissues and controls their functions and systemic homeostasis of energy and metabolic substrates, suggesting BAT as a metabolic regulator, other than for thermogenesis. This notion is supported by discovering that various paracrine and endocrine factors are secreted from BAT. We review the current understanding of BAT pathophysiology, particularly focusing on its role as a metabolic regulator in small rodents and also in humans.
Minimizing cones for fractional capillarity problems
Authors: Dipierro Serena , Maggi Francesco , Valdinoci Enrico
Published: June 2021

We consider a fractional version of Gauß capillarity energy. A suitable extension problem is introduced to derive a boundary monotonicity formula for local minimizers of this fractional capillarity energy. As a consequence, blow-up limits of local minimizers are shown to subsequentially converge to minimizing cones. Finally, we show that in the planar case there is only one possible fractional minimizing cone, the one determined by the fractional version of Young’s law.
Reproductive Traits and Somatic Growth of Diplodus sargus sargus (Linnaeus, 1758) in the Central Algerian Coast (Southern Mediterranean Sea)
Authors: Boufekane Bilal , Chakroun-Marzouk Nadia , Kelai Elyes , Alioua Zakia , Amira Soumia , Harchouche Kamel
Published: June 2021

This work provides useful knowledge on the reproductive traits and somatic growth of the white seabream (Diplodus sargus sargus Linnaeus, 1758) of the central sector of the Algerian coast. It aimed to estimate the maximum yield size of this sparid and evaluate its reproductive potential, by presenting the first results on its global fecundity. A total of 497 specimens, ranging in size from 12.4 to 40.3 cm, were monthly and randomly sampled from the artisanal fishery fleet, between January and December 2017. The obtained length-weight relationships indicated negative allometry for males (TW=0.024 TL2.842) and isometry for females (TW=0.016 TL3.013). The white seabream is a digynic protandrous hermaphrodite species. Sex reversal was observed with a large size overlap of 12 to 32 cm with a median of 23.5 cm. The reproductive season was observed from January to May and spawning occurred in spring. The size at first sexual maturity (TL50) was 20.55 cm for both sexes. Based on these results, the current legal minimum size of capture should be raised in the study area.
Longline Hook Selectivity for Branchiostegus japonicus (Houttuyn, 1782) and Dentex tumifrons (Temminck & Schlegel, 1843) in the East China Sea
Authors: Xu Guoqiang , Zhu Wenbin , Zhou Yongdong , Xu Liuxiong
Published: June 2021

Bottom longline fishing of red tilefish (Branchiostegus japonicus) is one of the most important commercial of fishing in the East China Sea. The present study aimed to investigate hook selectivity in B. japonicus and D. tumifrons, by means of experiments using three hook sizes (“J”: #15, #13 and #11) and was conducted in the East China Sea from June to August 2018. Altogether 602 B. japonicus fish and 858 D. tumifrons fish were caught. With respect to the size of the hook used, the total length-frequency varied significantly for both B. japonicus and D. tumifrons that were caught. The total length and four mouth parameters (upper and lower jaw length as well as height and width of mouth opening) of the two species showed a positive linear relationship. A logistic model created using the maximum likelihood method was used for elucidating hook selectivity; the best fit model with the minimum Akaike’s Information Criterion value was selected as the final model. The 50% selection lengths were 224.827 and 233.179 mm for B. japonicus; 201.461 and 202.603 mm for D. tumifrons using “J” #13 and “J” #11 hooks, respectively. To preserve the reproductive potential of younger fish in the stocks, the size of the “J” #13 hook was selected as the minimum hook size that should be used for the sustainable development of bottom longline fishing for B. japonicus and D. tumifrons.
Styl więzi, empatia i kody moralne jako predyktory postaw względem zachowań seksualnych okresu dzieciństwa
Authors: Tanaś Łukasz , Stępień Olga
Published: June 2021

Attachment Style, Empathy and Moral Foundations as Predictors of Attitudes Towards Sexual Behavior during Childhood The study explores the structure of adult (N = 170, Mage = 30) beliefs regarding the sexu­ality of preschool children (Ratkowska-Pasikowska, Pasikowski, 2013). Furthermore it evaluates the probable predictors of these beliefs: avoidance and anxiety dimensions of attachment, moral foundations and the levels of cognitive and affective empathy. Results show a two-factor differen­tiation of beliefs regarding children’s sexuality. Adults make a distinction between intrusive behav­iors, related to verbal aggression or potential violation of other people’s intimacy, and behaviors combining sexuality with curiosity and role-playing. The former category is generally less accepted than the latter. At the same time, higher level of cognitive empathy and a lower level of endorse­ment in the sphere of purity/sanctity as a foundation of moral evaluation, is a general predictor of higher acceptance of sexual behaviors in both categories. Higher level of attachment anxiety pre­dicts a higher acceptance of intrusive sexual behaviors, and a higher level of attachment avoidance predicts a lower acceptance of such behaviors. These results are discussed within the context of their importance for the future studies on childhood sexuality with parents as the potential inform­ants on behavior of their children.
Specyfika rozwojowa struktury pamięci dzieciństwa w biegu dorosłego życia – wyniki badań narracyjnych
Authors: Jezierski Kamil
Published: June 2021

Developmental Specificity of Childhood Memory Structure across the Adult Lifespan – Results of Narrative Research

Theories of autobiographical memory and narrative identity allow us to assume that childhood memory is represented in the mind of an adult person as a comprehensive period with its own unique characteristics that is subjected to changes during the lifespan. Based on the concept of the global coherence of life history, it was assumed that in later periods of life, childhood memories will be more elaborate and thus cognitively more accessible as well as organized temporally and logically in a more coherent story.

The use of narrative interview revealed differences between early, middle and late adulthood in the way the childhood memories are organized, as well as in the age-independent characteristics of the perceived childhood. The obtained results suggest that in late adulthood, childhood is recalled more extensively and more memories are logically organized, which is attributed to greater attention to the past resulting from the task of life summary. Regardless of the age of the respondents, less than half of the memories related logically to each other, with most of the text consisting of separate scenes not located in time. These findings raised the issue of the specificity of childhood memory and the universality of global coherence of life stories.
Ensuring Sustainable Value from Consultants
Authors: Czerniawska Fiona
Published: June 2021

Decision-makers tend to view consulting projects in a positive light because that validates their decision to use consultants. That consultants know what they are doing is an undoubted prerequisite for success across all types of projects, not just people-related ones. The more knowledgeable a consultant has proved to be, the more satisfied the client is. Communication is another area where the gap between satisfied and unsatisfied clients is greatest. Among consulting projects that have gone well, it is hard to find a single one that has not involved a joint client-consultant team. Moreover, integration is not just a question of people working together or being based in the same physical location.
New Product Development and Disciplined Experimentation
Authors: Sola Davide , Scarso Borioli Giovanni , Scalabrini Gianfranco
Published: June 2021

The process of developing new products always contains an element of uncertainty. This uncertainty translates into a significant risk for companies investing in the development of new products or services. The risk in new product development (NPD) can be based on ‘disciplined experimentation’: a structured process designed to rapidly identify the ‘vivid’ needs of the customer, test whether the main features of the new product or service will satisfy these needs (fast prototyping). ‘Disciplined experimentation’, in particular, addresses assumptions about value (how the initiative will produce outcomes that outweigh the effort involved), growth (how the initiative can be scaled up beyond the first group of customers) and sustainability (how quickly the organisation can adapt to the new initiative and how easily competitors will be able to replicate it).
Economies of Scale and Network Economies in Industry 4.0. Theoretical Analysis and Future Directions of Research
Authors: Büchi Giacomo , Cugno Monica , Castagnoli Rebecca
Published: June 2021

This paper analyses the role of cost differentials in the fourth industrial revolution. It uses a literature review in order to identify origins, definitions, enabling technologies and changes in company productivity. Research results show how certain Industry 4.0 enabling technologies help obtain better economic results in mass production and others that support new production models in mass production: mass customization and mass personalization. This paper is of a theoretical nature and identifies certain reflections concerning Industry 4.0’s role in managerial literature by providing interesting lines to be developed in future directions of research.
Information Technology and Work: Threats and Opportunities
Authors: Camussone Pierfranco , Biffi Alfredp
Published: June 2021

Innovation is creating robots and computers that are able to perform many tasks previously accomplished by man. The place occupied by men in the job field will shrink. The current organization and the existence of many jobs are in danger. In the article we discuss the treats and opportunities of using ICT in business and the impact on business models and on the human’s job. Through a survey on Italian business context we observe the awareness of the people directly involved in decision making and in designing future work in the firms. The consciousness of the people on the effects of the diffusion of ICT matches with the opportunities for doing business. How to find the right equilibrium between the two perspectives?
The Impact of the 4th Industrial Revolution on the High-Tech Industry
Authors: Trento Sandro , Bannò Mariasole , D’Allura Giorgia
Published: June 2021

The challenges of  the 4th Industrial Revolution (I40) entail new business models to improve customer value creation. So far, academic investigation into I40 has been extensively focused on large enterprises, and only marginally on SMEs. The present paper aims to answer to the following four research questions: How do manufacturing SMEs perceive the I40 phenomenon? How do manufacturing SMEs innovate their business models because of I40? How do manufacturing SMEs behave with their suppliers because of I40? How do manufacturing SMEs behave with their customers because of I40?
Sustainable Development and Environmental Sustainability in Large-Scale Retailers
Authors: Riboldazzi Sabina
Published: June 2021

Mounting pressures from society demanding higher standards in business ethics, along with a growing number of consumers and several other market players sensitive to issues concerning corporate social responsibility and sustainable development, have encouraged the adoption of new behaviors by those large-scale retailers seeking to achieve positive business results through economic effectiveness and efficiency while respecting human rights, social balance, and the environment. The present study, through in-depth analysis of business practices of major domestic large-scale retailers, aims to assess, in the context of economic, social, and environmental responsibilities, the various initiatives developed by such retailers with respect to environmental protection.
La renta básica, la fuerza de trabajo y la crisis
Authors: Rey Pérez José Luis
Published: June 2021

La crisis financiera global que se inició en 2008 se ha traducido en el enésimo y parece que definitivo- ataque y recorte del Estado de bienestar y de sus prestaciones. ¿Tiene sentido en este contexto seguir hablando de la renta básica, un ingreso incondicionado y universal que se daría a todos los miembros de la comunidad política? ¿No resulta una provocación en una época en la que el Estado carece de recursos para pagar los servicios más esenciales? ¿Qué papel podría jugar la renta básica a comienzos del siglo XXI? En este trabajo se abordará la renta básica desde una perspectiva consecuencialista, centrándose en las funciones que podría cumplir en un mercado de trabajo gravemente afectado y como de forma indirecta contribuiría a revitalizar la democracia y construir una nueva ciudadanía. La renta básica no es la solución a la crisis, pero puede ser un importante pilar que ayude a la construcción de un nuevo modelo de trabajo y de democracia.
Rafael Altamira, un historiador del Derecho en el Tribunal permanente de Justicia Internacional (1921-1939)
Authors: Gamarra-Chopo Yolanda
Published: June 2021

Rafael Altamira y Crevea (1866-1959) fue un historiador del Derecho que contribuyó al desarrollo del Derecho internacional en su calidad de Juez del Tribunal Permanente de Justicia Internacional (TPJI), entre 1921 y 1939. En este contexto, el estudio trata del discurso renovador de Altamira recurriendo a la historia de la civilización española y recuperando los principios promovidos por los teólogos y juristas españoles del siglo XVI. Altamira concibió el Derecho como un instrumento civilizador, un elemento crucial para demostrar el carácter civilizado del pueblo español y el papel civilizador de España, en particular en América. La participación de Altamira en la creación de las instituciones internacionales demuestra su interés por promover la idea de España como nación civilizada en la sociedad internacional.
Inmigración, fenómeno de miles de facetas: enfoque para una sana convivencia
Authors: Iblè Kambiré Somda Michel-Ange
Published: June 2021

A partir de los años 80 se inicia una profunda transformación de la economía mundial, y aparece un proceso de globalización económica basado en la extensión planetaria del comercio libre y en definir el principio de la competitividad como motor del desarrollo. Es cierto que este modelo neoliberal ha estimado límites hasta ahora no conocidos el intercambio del capital, bienes e información. Sin embargo, este desorden económico internacional se está desarrollando sobre un espacio planetario de enormes diferencias estructurales, sobre las que se imponen formas globales de organización social, económica y cultural que están resultando gravemente injustas, según demuestra la realidad. Por ello los diferentes movimientos de migraciones de trabajadores, refugiados y desplazados es una consecuencia clara de este modelo de desarrollo.
Tres problemas para la concepción habermasiana de la democracia
Authors: Spector Horacio
Published: June 2021

La teoría discursiva de Habermas basada en el consenso de los participantes, siendo este consenso el fundamento de la corrección ética, ha sido objeto de crítica por sus limitaciones tanto en el terreno de la práctica como la teoría. El artículo pretende comentar y superar esas limitaciones. Es una tarea que deben realizar los partidarios de la democracia deliberativa, pues siempre la democracia deliberativa, en la que se concreta el discurso habermasiano, es más legítima que la democracia liberal. Las limitaciones aludidas en este artículo -la inconmensurabilidad discursiva, el dilema discursivo y la falla discursiva- podrían ser superadas y, aún si estos problemas no fueran totalmente superables, la democracia deliberativa es el mejor sistema político disponible.
Sequência didática sobre agricultura familiar
Authors: Anjos Jair Emanuel dos , Fonseca Eril Medeiros da , Duso Leandro
Published: June 2021

O objetivo deste trabalho caracteriza-se por investigar limites e potencialidades da aplicação de uma sequência didática na perspectiva de elementos da educação em Ciência-Tecnologia-Sociedade, que tem como tema norteador a agricultura familiar no ensino de Biologia. A sequência didática foi aplicada em uma turma de primeiro ano do ensino médio, em Santa Catarina. A pesquisa caracteriza-se como descritiva e utilizou, para coleta de dados, questionário, relatos produzidos pelo grupo de estudantes nos encontros, caderno de campo e memorial individual. Como resultado, apontam-se, como limites: tempo/contraturno, recursos financeiros, diálogo entre componentes curriculares; e como potencialidades: postura crítica e investigativa do estudante, ruptura com a fragmentação dos conteúdos, vivências nas saídas de campo, aproximação professor/estudantes e contribuições para alfabetização científica.
Anne Fausto-Sterling e o espectro de sexo/gênero
Authors: Tavares Bruno , Ramos Mariana Brasil , Mohr Adriana
Published: June 2021

É crescente o número de publicações sobre gênero na área de pesquisa em Educação em Ciências e Biologia. Contudo, são poucos os estudos teóricos que tratam do tema, e mais ainda, aqueles que abordam perspectivas epistemológicas feministas. Portanto, nosso objetivo é apresentar e discutir algumas contribuições teóricas sobre sexo/gênero para o ensino de Ciências e Biologia, a partir dos estudos de Anne Fausto-Sterling. Ressalta-se que a noção de sexo/gênero como espectro proposta pela autora é relevante para problematizar os binários rígidos macho-fêmea ou homem-mulher, auxiliando na construção de um ensino de Ciências e Biologia alinhado às diversidades corporais, sexuais e de gênero.
formação inicial do licenciado em ciências biológicas e o tema sexualidade
Authors: Corbagi Eula Raissa Chaves de Almeida , Bonzanini Taitiâny Karita
Published: June 2021

Práticas formativas devem relacionar-se com desafios vividos pelos profissionais cotidianamente, envolvendo domínio e construção de saberes exigidos na atividade docente. Portanto, este artigo objetivou discutir a formação do licenciando em Ciências Biológicas no tema sexualidade. Para tanto, foram submetidas à análise documental ementas de disciplinas obrigatórias e entrevistas semiestruturadas aplicadas aos discentes em 2016. Observou-se justificativa para abordagem do tema em 17 disciplinas, contudo, o curso pouco contribui à formação de professores aptos a trabalhá-lo na educação básica apesar de conter momentos propícios ao seu aprofundamento. Sugere-se que as licenciaturas passem a olhar favoravelmente à abordagem da sexualidade na formação docente, podendo considerar debates promovidos pelo movimento estudantil, salvo adequação metodológica, para desenvolver saberes necessários ao exercício da profissão docente.
Entre nudes, vingança pornográfica e sexting
Authors: Barros Suzana da Conceição de , Ribeiro Paula Regina Costa
Published: June 2021

Neste texto, procuramos discutir a importância do ensino de Biologia nas discussões vinculadas à prática do sexting. Essa prática consiste no compartilhamento e postagem de mensagens, fotos e vídeos de conotação sexual, sensual e erótica, por meio de tecnologias digitais, para namorados/as, ficantes, paqueras, amigos/as ou para uma multidão de conhecidos/as e desconhecidos/as. A disciplina de Biologia, é entendida como um espaço autorizado a discutir sobre os corpos e as sexualidades, no entanto, essas discussões são ancoradas em saberes biomédicos, orgânicos e higienista. Entendemos que o ensino de Biologia, deve levar em consideração as relações sociais, culturais e políticas, que envolvem as temáticas de corpos, gêneros e sexualidades, abrindo brechas para que discussões como o sexting, ocorram na escola.
Gênero e sexualidade como componentes curriculares na formação inicial de professoras de ciências e biologia do Rio de Janeiro, RJ
Authors: Santos Raquel Alexandre Pinho dos
Published: June 2021

Esse artigo tem por objetivo compreender de que forma doze licenciaturas de Biologia na cidade do Rio de Janeiro (RJ) inserem os temas de gênero e sexualidade na sua estrutura curricular. Para isso, foi realizado um mapeamento dessas instituições e visitas para marcação de entrevistas com coordenadoras e professoras. Ao todo, foram realizadas dezesseis entrevistas. Além disso, alguns documentos curriculares serviram de apoio para a análise. Nas grades curriculares, foram encontradas quatro disciplinas obrigatórias que tangenciavam o tema e duas eletivas que tinham o tema como essência. Nas entrevistas, percebi que a inserção se dá por um gancho temático, por conflito de opiniões ou pela determinação da instituição. Não há consenso quanto a disciplinarização ou a transversalização do tema.
“Parece que é normal conviver com uma pessoa que tem HIV”
Authors: Souza Laís Machado de , Souza Marcos Lopes de
Published: June 2021

O objetivo desse estudo foi analisar os discursos sobre as relações afetivo-sexuais entre sorodiscordantes construídos por professoras durante processo formativo envolvendo as questões de sexualidade e saúde. Trata-se de uma pesquisa ancorada nos estudos pós-críticos e pós-estruturalistas em que utilizamos artefatos culturais como mediadores dos momentos formativos realizados com professoras da área de Ciências Naturais, que lecionam a disciplina Educação para Sexualidade em uma escola na cidade de Jequié-BA. Há uma linha tênue entre ignorância, medo e discriminação nos discursos das professoras referentes às relações entre sorodiscordantes, mas também vislumbramos novas perspectivas de problematizações das práticas e discursos que (re)produzem uma cultura estigmatizante daqueles(as) que vivem com  HIV/aids e a vivência de seus afetos e prazeres.
Viure menys anys i en pitjor salut: el peatge de la població amb menor nivell educatiu a Espanya
Authors: Blanes Amand , Trias-Llimós Sergi
Published: June 2021

Més de tres anys separen l’esperança de vida als 30 anys dels grups més intruïts en relació als que tenen uns nivells educatius més baixos. A les darreres dècades s’ha produït una substancial millora en la longevitat de la població espanyola, però aquestes millores emmascaren la persistència de significatives desigualtats en salut i mortalitat. El nivell socioeconòmic discrimina l’estat de salut de les persones al llarg de la seva vida, essent l’educació un dels indicadors més emprats en els estudis sobre desigualtats socials en mortalitat i salut. El nivell educatiu, a més de ser una variable indirecta de la situació socioeconòmica, condiciona en gran mesura els estils de vida i les preferències cap a la salut de les persones, així com l'ús que fan dels recursos del sistema sociosanitari. En aquest número de Perspectives Demogràfiques abordem les diferències actuals de mortalitat i salut a Espanya segons el nivell educatiu. Aquestes desigualtats poden resumir-se com una triple penalització de les persones amb menys educació en relació amb les més instruïdes: a) una menor esperança de vida; b) una major desigualtat en l’edat a la mort; i c) una menor proporció de la seva vida amb qualitat de vida.
Vivir menos y con peor salud: el peaje de la población menos instruida en España
Authors: Blanes Amand , Trias-Llimós Sergi
Published: June 2021

Más de tres años separan la expectativa de vida a la edad 30 de los grupos más instruidos en comparación con aquellos con niveles de instrucción más bajos. En las últimas décadas se ha asistido a un sustancial avance en la longevidad de la población española, pero esas mejoras enmascaran la persistencia de significativas desigualdades en salud y mortalidad. El nivel socioeconómico constituye un factor discriminante del estado de salud de las personas a lo largo de su vida, siendo la educación uno de los indicadores más utilizados en los estudios sobre desigualdades sociales en mortalidad y salud. El nivel educativo, además de variable indirecta de la situación socioeconómica, condiciona en gran medida los estilos de vida y las preferencias hacia la salud de los individuos, así como el uso de los recursos del sistema sociosanitario. En este número de Perspectives Demogràfiques abordamos las actuales diferencias en mortalidad y salud en España según nivel educativo. Esas desigualdades pueden sintetizarse como una triple penalización de los menos instruidos en relación con los de mayor nivel educativo: a) unas menores expectativas de vida; b) una mayor desigualdad en la edad a la muerte; y c) una menor proporción de años con calidad de vida.
The System of Governance in Malaysia, and the Extent of its Effectiveness in Islamic Banks and their Windows in Algeria
Authors: Chourana Mohamed , Bensayah Sana , Kashi Aghilas
Published: June 2021

This study aimed mainly at identifying the principles of governance in Islamic banks and measuring the extent to which these principles are applied in Islamic banks in Algeria, because what distinguishes Islamic banking is the existence of a Sharia supervisory board that looks at the activities and contracts that result from it. Islamic law as a reference for it in all items. Some countries, on top of them Malaysia, have established the Sharia advisory board at the level of the Central Bank of Malaysia, which is the authority empowered to verify the implementation of the provisions of Islamic law and its obligation in the work of Islamic banks Which represents the Sharia governance of Islamic banks. This research studies the extent to which the political administration provides the necessary infrastructure for the development of the emerging Islamic financial industry in Algeria in all fields, legal, sharia and Financial. Is it possible to establish a Sharia governance system with its controls and standards in the management of Islamic banks in Algeria, and to establish a central law for advisory and Sharia councils? And to what extent is the governance system considered and the extent of its effectiveness considered in Islamic banks, taking advantage of the Malaysian experience? Especially since Algerian Islamic banks do not have the confidence of civil society due to the absence of legitimate governance foundations in them.
Examples of the Most Prominent Contemporary Challenges in the Science of Da’wah
Authors: Hassan Muhammad Ghaleb
Published: June 2021

In his research, the researcher discussed the definitions of Dawah (calling to Allah), its importance, and its status in Islamic legislation. He spoke in his research about the most prominent challenges that face modern-day Dawah, which are represented by three issues, and they are: The first issue: Challenges in the field of Dawah. The second issue: Challenges in authored books concerning Dawah. The third issue: Challenges in preparing callers to Allah. In his discussion of the first issue, he touched upon the most prominent challenges in the field of Dawah, from which is the multiplicity and presence of opposing Manahij (the way groups of people choose to practice religion, and their beliefs) that are against the scholastic and moderate Manhaj that Islam came with. The researcher also suggested several solutions for that, from amongst them is: Firstly: Governmental religious authorities should play an active role in monitoring religious activities and raising awareness of the dangers of dawah partisans. In his discussion of the second issue, the researcher clarified the importance of authoring books in the science of Dawah, and clarified the flaw present in this field, which is: Repetitive authorship of the same issues and books that aid false manahij, and presented a group of suggestions concerning that. And in the discussion of the third issue: The researcher spoke about the importance of preparing and qualifying callers to Allah, a scholastic preparation, a technical preparation, and a knowledge-related preparation, and that is to enable them to keep pace with the developments of the time, and the advancement of sciences. And finally, he ended his research with the conclusions he reached, asking Allah tawfeeq and correctness for all
Provisions for Entitlement to Wages when Benefits are not Satisfied Contemporary Applications in Judicial Rulings Kuwait as a Model
Authors: Al-Uthman Abdullatif Badr
Published: June 2021

The research contains a study of the legality of reducing wages in continuous contracts through the provisions of the status of pandemics in Islamic Sharia compared to commercial law in the State of Kuwait. The study also includes discussion about the relationship of wages to benefit and obligation in contracting, and a statement of the theory of emergency conditions, and the consequent obligation to pay the full rent, as happens at the time of closing the shops as a health precaution from the government, to mitigate the spreading the epidemic, and how does the tenant obligate the effects of the contract when he is unable to fully benefit? Especially since the period of precautionary measures has reached for several months, and debts and losses have accumulated on both parties, and judicial rulings have appeared in the court to reduce the rent of the property during the period of government closure, and here the comparison will be made between the provisions of Islamic Sharia, the Commercial Law, and the final rulings on the legality of reducing the rent.
GÖZÜBÜYÜKZÂDE İBRÂHİM EFENDİ VE MECMUATÜ’R-RESÂİL’İNDEKİ ARAP DİLİNE DAİR RİSALELERİNİN İNCELENMESİ
Authors: UÇKAN Şemsettin , ABAK Bahattin
Published: June 2021

Gözübüyükzâde İbrâhim Efendi 18-19. Yüzyılda Kayseri’de yaşamış Osmanlı âlimlerindendir. İslamî ilimleri çeşitli medrese ve âlimlerden tahsil etmiş, ömrünü talebe yetiştirerek geçirmiştir. İleri görüşlü ve ince meseleleri çözmedeki mahareti sebebiyle Gözübüyükzâde lakabı verilmiştir. Tedrîsin yanı sıra birçok alanda eser telif etmiş olan Gözübüyükzâde’nin eserleri başta Süleymaniye Kütüphanesi olmak üzere birçok kütüphanede yazma ve matbu olarak bulunmaktadır. Âlimin birçok risalesi Mecmu'atü’r-resâil adlı mecmuada toplanmış olup neşredilmiştir (İstanbul 1259).

Mecmua içerisinde Risâletün fî kelimeti emmâ ba‘dü, Risaletün fî sukût hemzeti ibn beyne ‘alemeyn, Risâle fî hakki’l-istisnâ gibi Arap diline dair bir çok risale mevcuttur. Çalışmada Mecmu'atü’r-resâil’teki Arap diline dair eserler ele alınıp, risalelerin yazılış amaçları, muhtevaları ve risalelerde kullanılan kaynaklar hakkında bilgi verilecektir. Bu vesile ile kültürümüzün alimlerinden birinin hayatı, eserleri ve Arap diline katkıları ortaya çıkarılacaktır.
Muhasebe Bölümü Öğrencilerinin Muhasebe Eğitimini Etkileyen Tutumların Belirlenmesi
Authors: BÜYÜKARIKAN Ulukan
Published: June 2021

The most important aim of accounting education; is to bring quality members of professional accountancy as well as high-quality individuals who can express themselves, have high communication skills, and keep up with current developments. Therefore, the level of proficiency of accountants needs to be continuously enhance and improved. So, it is necessary to determine the factors affecting the accounting education of the students who will do the accounting profession in the future. The study, it was aimed to determine the attitudes of the accounting department students about both accounting courses and the operation of accounting courses. In this status, 3rd and 4th-class students studying in the accounting department were included in the study. In this context, the data were analyzed using frequency, factor analysis and Independent-Samples T-Test. It was determined that there are significant differences between students who use accounting programs and "accounting course love" and “the positive aspects of presentation” sub-factors.
ŠTA SPAJA A ŠTA RAZDVAJA KOGNITIVNOLINGVISTIČKI I KONITIVNOPRAGMATIČKI PRISTUP METAFORI?
Authors: Rasulić Katarina , Mišković-Luković Mirjana
Published: June 2021

This paper provides a comprehensive comparative reassessment of the state-of-art in the theory and practice of the two prominent contemporary approaches to metaphor – cognitive-linguistic conceptual metaphor theory and cognitive-pragmatic relevance theory – given their professed aim at formulating an explanatorily adequate cognitive theory of metaphor. So far, to our knowledge, there are but a handful of publications that have seriously dealt with this comparative issue (Tendahl and Gibbs 2008, Tendahl 2009, Stöver 2010, Gibbs and Tendahl 2011, Wilson 2011); illuminating as they are, they are, nonetheless, biased in that they remain deeply rooted in their respective theoretical backgrounds. Working within the two observed theoretic approaches to metaphor, our primary aim was to show that the differences may be more apparent than real. To this purpose, we present a synthetic and critical overview of both approaches, alongside with a comparative analysis of illustrative data from the contemporary Serbian language. Our combined approach, cognitively induced, relies on the elaborate conceptual apparatus of cognitive linguistics teamed with an interpretive understanding of metaphor within the cognitive-pragmatic framework, highlighting the lines of in- terface and the converging evidence towards a better understanding of metaphor as a cognitive–communicative mechanism.
ŽANROVSKA POLIVALENTNOST PRIPOVEDANjA IVANE DIMIĆ (ZBIRKA KRATKIH PRIČA „POPIS IMOVINE“ I ROMAN „ARZAMAS“ IVANE DIMIĆ)
Authors: Andjelic Sanja
Published: June 2021

Genre diversity that is characteristic of Ivana Dimić’s opus becomes
evident in the structure of her works – in her collection of short stories List of assets,
short stories are followed by drama, while on the other hand, in her novel Arzamas
short stories alternate with drama parts. It is important to emphasize that genre
variety becomes the theme of both works. Short stories included in the collection
have a specific form – the point is set at the beginning of the narration, the narrator,
who is the author herself, starts the narration in medias res, and some of the stories
have a fairy tale opener and are often allegorical. In her novel, the author uniformly
models the short stories by choosing in medias res technique as dominant and by
giving advantage to the theme that prevails in both of her works – the relationship
between love and death which often leads to ambivalent feelings of the narrator.
STUDENT METACOGNITIVE AWARENESS IN L2 WRITING: COMPETENCE VS. PERFORMANCE
Authors: Milenkovic Branka
Published: June 2021

Writing in a second language certainly embodies constraints that are not met in L1 writing due to numerous decisions L2 learners make while producing a text. Many researches have shown that L2 writing is largely based on decision-making with relation to form and search for appropriate words which make the writing process even more complex and time-consuming. Therefore, communicating with the readers through the use of metadiscourse poses an addi- tional obstacle in L2 writing. This paper is concerned with the use of metadiscourse markers in L2 student writing at the Department of English language, at the University of Kragujevac in Serbia. In essay writing research we frequently observe quantitative analysis of specific lan- guage items, however, in this research, we attempt to juxtapose the quantifiable metadiscourse items in student writing with their thinking processes and decision-making while composing. Thus, the research correlates three insights, one being the students’ liability to deep writing, which relies on their metacognitive awareness in writing, established through the modified questionnaire of the Inventory of Processes in College Composition (Lavelle and Zuercher 2001) and based on previous research (Milenkovic & Lojanica 2015). Students’ responses are then correlated with the analysis of 33 student essays on behalf of the use of metadiscourse mark- ers based on A model of metadiscourse in academic texts established by Hyland and Tse (2004). Finally, the students’ metacognitive awareness in writing is analyzed through an introspective questionnaire with the aim to yield qualitative responses in relation to their cognitive ability to reflect upon their writing. The results of the study confirm the common belief that using metadiscourse features is a constraint in L2 writing. Evidently there is a disproportion between the metadiscourse items students use in writing with relation to what they believe that they use and students have displayed more metacognitive awareness in relation to interactive resources as opposing to the interactional resources in academic writing. Implications of the results may establish a basis for a modified teaching practice in second language writing instruction with the aim to enhance students’ communicative competence in writing.
VON DER (UN)MÖGLICHKEIT DER VERSÖHNUNG MIT DEM WELTGEIST IM WERK FRIEDRICH HEBBELS UND FRIEDRICH NIETZSCHES
Authors: Petrovic Jülich Marina
Published: June 2021

Das Ziel der vorliegenden Arbeit ist es, mittels der Untersuchung der tragischen Auffassung Friedrich Hebbels und Friedrich Nietzsches die Gemeinsamkeiten in ihrem Gedankengut fest- zustellen und zu beweisen. Dazu habe ich mich der Methode des Vergleichs bedient, das heßt ich habe versucht, die Wechselbezihungen im Werk und Denken der beiden Autoren zu untersuchen. Hebbel, aber auch Nietzsche, haben sich oft in ihren Werken, aber auch in ihren Briefen und Tagebuchnotizen über das tragische Drama geäußert. Hebbel tat das desöfteren in Vorworten zu seinen Dramen und in unabhängigen Abhandlungen. Die Konzeption der beiden Dichter ist am engsten mit ihrer Weltanschauung verbunden.

Im zweiten Teil dieses Beitrags hat die Autorin versucht, durch die Analyse einiger, in unter- schiedlichen Schaffensphasen Hebbels entstandenen Dramen seine Auffassung vom Tragischen zu verdeutlichen. Mit Hilfe der Einzelanalysen und durch die werkimanente Annäherungsver- suche unter Hervorhebung des tragischen Aspektes sollte klar gemacht werden, dass in den späteren Dramen des Autors das Versöhnungselement eine größere Rolle spielt, obwohl es oft unnatürlich wirkt. Beispiele dafür sind die Heiligen drei Könige in Herodes und Mariamne oder der Versöhnungsakt zwischen Vater und Sohn in Agnes Bernauer. Man kann annehmen, dass Hebbel bis heute in der internationalen germanistischen Forschung einen untergeordneten Forschungsgegenstand darstellt, dass darauf zurückzuführen ist, dass gerade die Unmöglichkeit der Versöhnung des Individuellen mit dem Weltgeist und die übertriebene Unnatürlichkeit dessen nicht nur den jugendlichen Lesenden zu fern von der Aktualität und den allgemein- menschlichen Bestrebungen erscheint.
Penerapan Tata Kelola Teknologi Informasi dan Pengukuran Maturity Level Menggunakan Domain MEA (Monitor, Evaluate Dan Assess) Dengan Framework COBIT (Studi Kasus: Sistem Informasi Akademik AIKOM
Authors: Sabtu Junaidi
Published: June 2021

The Academy of Computer Science (AIKOM) Ternate has implemented information technology in the Academic Information System (SIAK) section, which is an important part of connecting management with all stakeholders. Formulation of the problems raised in this study includes how to classify problems into statements that are in accordance with COBIT 5 framework and how to determine and measure the maturity level of IT governance at AIKOM Ternate by using the MEA (Monitor, Evaluate and Assess) domain. The researcher used a questionnaire instrument to measure the maturity level of IT governance at AIKOM Ternate. The sample used was 13 people including the leadership and several staff. Based on the calculation of the maturity level of IT governance, a value for MEA01 (Performance and Conformance) is obtained at 3.2, MEA02 (The System of Internal Control) of 3.3, and MEA03 (Compliance With External Requirements) of 3.3, which means that each subdomain is at level 3, which means Established Process, so that the average MEA maturity level is 3.3, which is in the Established Process status. The results of the recommendations of this study are for MEA01 subdomains need to establish guidelines and SOPs for the implementation of monitoring and evaluation of SIAK, there needs to be monitoring from the leadership of the duties of each stakeholder and set the standard reporting process from data collection, time and feedback from report results. The recommendation for the MEA02 subdomain is that AIKOM Ternate must develop a mechanism for controlling SIAK, develop SIAK quality assurance standards and carry out periodic evaluations of quality assurance. And recommendations for the MEA03 subdomain carry out periodic reviews and make guidelines and SOPs related to SIAK changes based on external changes.
Penerapan Metode Analytical Hierarchy Process (AHP) Dalam Sistem Pendukung Keputusan Penilaian Kinerja Guru
Authors: Rohmat M.Andi , Kusrini
Published: June 2021

Sistem penilaian kinerja guru di SMK Airlangga Balikpapan dilakukan sebagai formalitas namun tidak ada suatu usaha perbaikan apapun dari pihak sekolah. Sehingga dibutuhkan suatu rancangan sistem penilaian kinerja yang dapat memotivasi kinerja guru SMK Airlangga Balikpapan. Untuk itu dirancang sistem penilaian kinerja guru berbasis kompetensi, khususnya Kompetensi Standar Kualifikasi Akademik dan Kompetensi Guru yang dipadukan dengan Kompetensi Gomes. Tahap awal dilakukan perhitungan bobot pada tiap kompetensi menggunakan kuesioner pembanding berpasangan yakni dengan metode AHP. Selanjutnya dilakukan penilaian dengan menggunakan kuesioner menggunakan metode penilaian Rating Scale. Hasil dari penilaian tersebut diolah sehingga didapat prestasi kerja dari masing-masing guru. Adapun dalam penelitian ini menggunakan 4 kriteria dan 8 sub kriteria. Dalam penelitian ini alat bantu pembuatan aplikasinya menggunakan bahasa pemrograman PHP, sedangkan basisdata nya menggunakan MySQL. Hasil akhir dari penelitian ini didapatkan bahwa sistem pendukung keputusan dengan metode AHP mampu mengatasi permasalahan dalam melakukan penilaian kinerja guru di SMK Airlangga Balikpapan.
Association of APOE polymorphisms with lipid-lowering efficacy of statins
in atherosclerotic cardiovascular diseases
Authors: Wang Yuexi , Du Xiaohong , Zhao Ruifen , Niu Juan , Wang Haixu , Li Jing
Published: June 2021

Introduction: Apolipoprotein E (APOE) gene is a promising candidate for the diagnosis of
hyperlipoproteinaemia and atherosclerosis. Polymorphisms in APOE have been reported to result in
differential efficacies of statins in atherosclerotic cardiovascular diseases.
Method: We classified APOE genotypes of 225 patients treated with atorvastatin and analysed the
relationship between genotypes and blood lipid levels.
Results: The baseline levels of total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C)
were significantly lower in APOE ε4 than APOE ε3 carriers. Levels of TC and LDL-C decreased
significantly after 1 month of atorvastatin treatment. Statins have a higher significant effect in reducing
TC and LDL-C levels in APOE ε4 genotype.
Conclusion: Polymorphism in APOE is related to the efficacy of atorvastatin in reducing the levels
of TC and LDL-C.

Keywords: Apolipoprotein E, lipid-lowering efficacy, polymorphism, statin, total cholesterol
Prime Numbers in Layers
Authors: ŞENER Cengiz
Published: June 2021

In this article, unlike the known deterministic and probabilistic methods used in determining prime numbers, a new type of deterministic method based on only algebraic analysis will be proven without creating a designed equation and without writing preliminary assumptions and prerequisites. For this, in the layers of the numbers in mod 30, it will be proven that the places 30k+1, 30k+7, 30k+11, 30k+13, 30k+17, 30k+19, 30k+23, 30k+29 where the prime numbers except for the first three locate, form a closed system in themselves. These eight locations will be referred to as eight layers and it will also be explained that the prime numbers are distributed equally across eight layers (equidistribution principle) in the closed system. With this new method, it will also be shown that there are possibilities to reduce the processing load considerably.