bluuebunny/crossref_metadata_2025 huggingface dataset:
Implementation of Wahdatul Ulum at FITK UINSU Medan
Authors: Nasution Abdul Fattah , Albina Meyniar , Syaifullah Muhammad
Published: September 2024

Penelitian ini dilaksanakan karena adanya dikotomi keilmuan yang selama ini terjadi, khususnya di Perguruan Tinggi. Penelitian ini berlokasi di Fakultas Ilmu Tarbiyah dan Keguruan Universitas Islam Negeri Sumatera Utara dengan jenis penelitian kualitatif dengan menggunakan metode wawancara dan dokumentasi. Sumber data penelitian ini adalah Dekan, Wakil Dekan I, Dosen Mata Kuliah Wahdatul Ulum, Sekretaris Pusat Wahdatul Ulum dan Mahasiswa yang sudah belajar Wahdatul Ulum. Adapun hasil penelitian ini menunjukkan bahwa: (1) Nilai-nilai Wahdatul Ulum telah termaktub dalam visi-misi sesuai Statuta Universitas Islam Negeri Sumatera Utara, Medan dan keluarnya aturan bahwa pembelajaran Wahdatul Ulum khususnya mata kuliah adalah wajib untuk seluruh fakultas dan prodi, maka Fakultas Ilmu Tarbiyah dan Keguruan menerapkan mata kuliah Wahdatul Ulum dilaksanakan pada semester awal sejak tahun 2021-2022. Selain menjadikan Wahdatul Ulum sebagai mata kuliah, Pimpinan (Dekan) juga menerapkan seluruh perangkat pembelajaran khususnya RPS berbasis Wahdatul Ulum. Hal ini sesuai hasil temuan bahwa FITK memprogramkan rapat untuk penyusunan RPS berbasis Wahdatul Ulum. Pada Fakultas Ilmu Tarbiyah dan Keguruan, bahwa pembelajaran Wahdatul Ulum sudah diterapkan pada jenjang S1 dan untuk S2 dan S3 dengan program yang diorientasikan pada kemampuan riset tentang keilmuan, masalah kebangsaan, dan peradaban; (2) Pembelajaran Wahdatul Ulum di Fakultas Ilmu Tarbiyah dan Keguruan berjalan dengan baik, hal ini sejalan dengan hasil wawancara Dekan dan Wakil Dekan 1 FITK, hal ini senada dengan sekretaris pengurus pusat Wahdatul Ulum, yaitu bapak Dr. Mohammad Al Farabi, M.Ag serta Dosen Pengampu Mata Kuliah Wahdatul Ulum.  Berdasarkan dari hasil wawancara, bahwa pernyataan dosen pengampu mata kuliah Wahdatul Ulum, menerima pembelajaran Wahdatul Ulum. Nilai-nilai Wahdatul Ulum sudah terintegrasi dalam RPS dari semua mata kuliah dan seluruh mahasiswa yang belajar wahdatul ulum menerima pembelajaran Wahdatul Ulum, dalam arti bahwa pembelajaran Wahdatul Ulum sudah terlaksana dengan baik; dan (3) Pembelajaran Wahdatul Ulum dapat mengembangkan pola pikir mahasiwa dengan integrasi keilmuan, tanpa adanya dikotomi keilmuan. Pembelajaran Wahdatul Ulum meningkatkan kesadaran mahasiswa bahwa sumber keilmuan adalah Allah Swt, maka dengan menyadari sumber keilmuan dan menyadari bahwa semua ilmu saling berkaitan, pola pikir mahasiswa terbuka dan dapat menerima kekurangan serta menghilangkan dikotomi keilmuan dalam diri mahasiswa. Mahasiswa yang belajar Wahdatul Ulum, memiliki pemikiran yang terbuka, menerima kekurangan, dan mental kuat dalam menghadapi masalah, hal ini sesuai pada hasil temuan dari indikator growth mindset.
Implementasi Manajemen Strategik Lembaga Pendidikan Islam dalam Meningkatkan Public Interest di SMP Islam Sunan Gunung Jati
Authors: Nashihudin Moh , Azizah Muhimatul
Published: September 2024

Penelitian implementasi manajemen strategik lembaga pendidikan Islam untuk meningkatkan public interest ini dilakukan untuk mendapatkan gambaran terkait implementasi manajemen strategik di SMP Islam Sunan Gunung Jati Ngunut Tulungagung. Tujuan dari penelitian ini untuk mendeskripsikan implementasi manajemen strategi lembaga pendidikan Islam dalam peningkatan public interest yang difokuskan pada pengembangan program, anggaran, dan standar operasional prosedur di SMP Islam Sunan Gunung Jati Ngunut Tulungagung untuk meningkatkan public interest. Penelitian ini menggunakan jenis penelitian kualitatif dengan pendekatan fenomenologi yang memotret kejadian apa adanya sesuai kenyataan yang terjadi di lapangan. Sedangkan pengumpulan data menggunakan observasi, wawancara, dan dokumentasi. Analisis data dengan menggunakan metode analisis deskriptif. Hasil dari penelitian ini menunjukkan bahwa implementasi manajemen strategik yang meliputi pengembangan program, anggaran, dan standar operasional prosedur memberikan dampak positif dalam ranah pendidikan di SMP Islam Sunan Gunung Jati dalam meningkatkan public interest.
Challenges of Writing Research Articles in English for University-Level EFL Teachers
Authors: Tiwari Hari Prasad
Published: September 2024

Writing research articles in English is a challenging task for non-native speakers of English, as it requires linguistic competence, rhetorical awareness, disciplinary knowledge, and familiarity with the research writing conventions. The qualitative study explores English non-native speakers' challenges while writing research articles (RAs) in English. The participants were 12 university-level English as a Foreign Language (EFL) teachers selected using snowball sampling. The data was collected using semi-structured interviews and analyzed using a thematic approach. The findings revealed four challenges: linguistic, rhetorical, disciplinary, and cultural. Linguistic challenges affect the clarity and credibility of the writing. In contrast, rhetorical challenges involve following the conventions, arguments, and citations of RAs in English. Disciplinary challenges require adapting to the norms and practices of different fields of study, and cultural challenges reflect the preferences for directness, formality, and objectivity in writing. The study shows the complexity and interrelatedness of these challenges and suggests a flexible and nuanced approach to overcome them.
Influence of Teacher Attributes on the Use of Resources in Teaching English Grammar
Authors: Odutayo Adesegun Olayide , Ishola Abdulkareem Farooq , Adewuyi Habeeb Omoponle
Published: September 2024

English is a critical subject at every stage of the Nigerian educational system, so it is imperative to guarantee success that corresponds with the substantial resources and time invested in teaching and studying. This research looked at the influence of teachers' attributes on using resources to teach English grammar in English by adopting a descriptive survey research design. All English language instructors employed in public and private secondary schools in Ilorin were the subject of this investigation. This study’s sample comprised 268 English language instructors. A questionnaire created by the researchers was utilized. The data gathered was subjected to reliability assessment using Pearson’s Product Moment Correlation (PPMC). There was a 0.81 correlation coefficient. Mean and percentage were chosen to respond to the study questions posed. The One-Way Analysis of Variance (ANOVA) and the independent t-test were used to evaluate the generated hypotheses at the 0.05 significant level. The results show that the most regularly utilized resources for teaching English grammar were print materials and textbooks, audiovisual aids, models and manipulatives, and digital technologies. It was recommended that curriculum designers continue to promote more realistically oriented materials, as this will help to engage students more and support the efforts of teachers.
Doble dimensión del derecho fundamental al cuidado. Una reflexión desde el alzheimer
Authors: Restrepo John Fernando , Sinisterra Quintero Juliana
Published: September 2024

El cuidado atraviesa las relaciones interpersonales, familiares y comunitarias y sostiene el núcleo relacional que da lugar al Estado Constitucional de Derecho. Genera una interdependencia entre el paciente y sus cuidadoras y cuidadores para poder sobrevivir. Hasta ahora, ha encontrado un espacio limitado de pensamiento, regulación, e interpretación jurídica. Se ha apartado el cuidado a la esfera familiar, partiendo de la base de que no debe pensarse en esta actividad también desde lo público, desde lo político. El cuidado, como actividad y necesidad humana, se ha percibido desde la carga o la culpa. La presente reflexión académica explica el derecho al cuidado en una doble dimensión que involucra una serie de derechos y condiciones para quienes tienen derecho a ser cuidados y los derechos de quienes cuidan. Tomando como referencia el alzheimer por ser catalogada una enfermedad de dependencia emocional y física entre paciente y su cuidador.
Hapax ἀνδρωδῶς (andrōdôs) w 1 Mch 6,31
Authors: Nawrot Janusz
Published: September 2024

Pojawianie się tzw. hapax legomena w danej księdze biblijnej stanowi zawsze wielką zagadkę rodzącą pytanie o cel ich użycia przez autora natchnionego. Posiada to tym większe znaczenie, że autorzy biblijni prezentują własne style i sposoby wyrażania myśli, używając do tego mniej lub bardziej wyraźnych, sobie właściwych terminów i składni zdaniowych. Przysłówek ἀνδρωδῶς stawia podobne pytania o swe miejsce w Pierwszej Księdze Machabejskiej. Niniejszy artykuł próbuje znaleźć odpowiedź na możliwy cel jego zastosowania przez hagiografa. Dlatego należy rozpatrzyć następujące kwestie. Po pierwsze, czy teologia samej księgi wystarczy by wytłumaczyć miejsce przysłówka w tym tekście. Po drugie, czy trzeba sięgnąć w tym celu do innych ksiąg Septuaginty. Po trzecie, czy należy doprecyzować znaczenie semantyczne omawianego przysłówka przez odwołanie do tekstów starożytnej literatury greckiej, w których się pojawia. Jak się wydaje, właśnie w jego znaczeniu, odkrytym w toku analizy, należy poszukać odpowiedzi na pytanie o cel zapisu dokonanego przez hagiografa.
Legal Institutions and Court Decisions as Instruments of Education for Peace in the Modern World
Authors: Sewerynik Jakub
Published: September 2024

Autor podejmuje próbę analizy roli wybranych instytucji prawnych i orzeczeń sądowych jako instrumentów wychowania do pokoju we współczesnym społeczeństwie demokratycznym. Autor skupia się w pierwszej kolejności na francuskim sekularnym modelu konstytucyjnym, opisując napięcie między państwem a religią, środki podjęte w celu wykluczenia symboli religijnych ze szkoły publicznej i socjologiczne konsekwencje tych działań. Analiza wybranych orzeczeń sądów pokazuje, jak znaczenie wolności religii jest bagatelizowana w europejskim systemie prawnym, co ma ogromne konsekwencje dla wychowania na rzecz pokoju w coraz bardziej różnorodnym społeczeństwie. W drugiej części artykułu Autor analizuje jedno z polskich pytań referendalnych z 2023 roku, wskazując na erozję debaty demokratycznej i funkcji edukacyjnej instytucji demokratycznych.
A Broad Understanding of Peace as a Foundation for Approaching Education for Peace
Authors: Piejka Agnieszka
Published: September 2024

The aim of this article is to show the most important implications of a broad understanding of peace for thinking about peace education. In the first part of my reflections, I recall the narrow definition of peace, which has its roots in antiquity. I point out that it is inadequate for complex peace processes, and I recall selected traditions of a broad understanding of peace. I also point out the most important tendencies in contemporary reflection on peace, highlighting the polysemantic nature of the concept of “peace” and the multifaceted and dynamic nature of peace processes. In the second part of the article, I list and discuss the most important implications of such a broad understanding of peace for thinking about education for peace. These are: the need to appreciate the role of education in building peace and to recognize it as a factor that is just as important as the actions of politicians and world leaders; the need to think about education for peace in an open way, always incomplete and permanently embedded in human education; and the recognition that the fundamental mission of education for peace is to develop in people a sense of subjectivity, personal responsibility for peace and a sense of responsibility for peace.
Judith Butler. ¿Qué mundo es este? Fenomenología y pandemia. Taurus. 2023
Authors: Córdova Pacheco Martín
Published: September 2024

The Covid-19 pandemic posed a profound challenge to our way of social organisation (whatever name we use to define it) that forced us to urgently design new ways of continuing with our daily lives despite the prohibitions imposed on our customs.
Molecular Modeling Insights on the Pharmaceuticals and Hypotheses of Alzheimer’s Disease
Authors: de Castro Alexandre A. , Silva Henrique F. , Garcia Maria V. F. P. , Homem-de-Mello Paula , Ramalho Teodorico C.
Published: September 2024

Alzheimer's disease (AD) stands as the predominant contributor to dementia
cases. The ongoing developments in our understanding of its pathogenesis have sparked
the interest of researchers, driving them to explore innovative treatment approaches. Existing
therapies incorporating cholinesterase inhibitors and/or NMDA antagonists have
shown limited improvement in alleviating symptoms. This, in turn, highlights the urgency
for the pursuit of more effective therapeutic options. Given the annual rise in the number
of individuals affected by dementia, it is imperative to allocate resources and efforts
towards the exploration of novel therapeutic options. This review aims to provide a comprehensive
overview of the AD-related hypotheses, along with the computational approaches
employed in research within each hypothesis. In this comprehensive review,
the authors shed light on using various computational tools, including diverse case
studies, in the pursuit of finding efficacious treatments for AD. The development of
more sophisticated diagnostic techniques is crucial, enabling early detection and intervention
in the battle against this challenging condition. The potential treatments investigated
in this analysis are poised to assume ever more significant functions in both preventing
and treating AD, ultimately enhancing the management of the condition and the
overall well-being of individuals affected by AD.
Development and Characterization of an Anti-PD-L1 Immunotoxin for Targeted Cancer Therapy
Authors: Takhteh Ali , Hosseininejad-Chafi Mohammad , Oghalaie Akbar , Behdani Mahdi , Kazemi-Lomedasht Fatemeh
Published: September 2024

Background:

Immunotoxins (ITs) represent a novel class of therapeutics with bifunctional
structures that facilitate their penetration through cell membranes to induce target cell
destruction. Programmed cell death ligand-1 (PD-L1), a human cell surface protein, is overexpressed
in various cancers. This study aimed to construct a novel IT by genetically fusing an
anti-PD-L1 Nanobody (Nb) to a truncated diphtheria toxin (DT).

Methods:

The IT construct comprised a 127-amino acid anti-PD-L1 Nb fused to a 380-amino
acid fragment of DT, with an N-terminal 6x-His tag. Molecular cloning techniques were employed,
followed by transformation and verification through colony-PCR, enzyme digestion, and
sequencing. The anti-PD-L1 Nb was expressed in WK6 E. coli cells induced by Isopropyl β-D-1-
Thiogalactopyranoside (IPTG) and purified from periplasmic extracts using immobilized Metal
Ion Affinity hromatography (IMAC). The IT was similarly expressed, purified, and validated via
SDS-PAGE and Western blot analysis.

Results:

ELISA confirmed the binding activity of both Nb and IT to immobilized PD-L1 antigen,
whereas truncated DT exhibited no binding. MTT assays demonstrated significant cytotoxicity
of IT on A-431 cell lines compared to Nb and truncated DT controls. Statistical analyses
underscored the significance of these findings.

Conclusion:

This study provides a thorough characterization of the constructed IT, highlighting
its potential as a therapeutic agent targeting PD-L1-expressing cancer cells. The results support
the potential of this IT in cancer immunotherapy, emphasizing the need for further investigation
into its efficacy and safety profiles.

result:

ELISA results demonstrated the binding activity of both Nb and IT to immobilized PD-L1 antigen, while truncated DT showed no binding. Cytotoxicity evaluation using MTT assay revealed significant toxicity of IT on A-431 cell lines compared to Nb and truncated DT controls. Statistical analyses confirmed the significance of these findings.
Beta-Hydroxybutyrate: A Supplemental Molecule for Various Diseases
Authors: Shahtaghi Navid Reza , Soni Bindu , Bakrey Hossamaldeen , Bigdelitabar Samira , Jain Subheet Kumar
Published: September 2024

:

β-hydroxybutyrate (BHB) is a ketone body that serves as an alternative energy source
for various tissues, including the brain, heart, and skeletal muscle. As a metabolic intermediate
and signaling molecule, BHB plays a crucial role in modulating cellular and physiological processes.
Notably, BHB supplementation offers a novel and promising strategy to induce nutritional ketosis
without the need for strict dietary adherence or causing nutritional deficiencies. This review article
provides an overview of BHB metabolism and explores its applications in age-related diseases.
This review conducted a comprehensive search of PubMed, ScienceDirect, and other relevant
English-language articles. The main findings were synthesized, and discussed the challenges, limitations,
and future directions of BHB supplementation. BHB supplementation holds potential benefits
for various diseases and conditions, including neurodegenerative disorders, cardiovascular diseases,
cancers, and inflammation. BHB acts through multiple mechanisms, including interactions
with cell surface receptors, intracellular enzymes, transcription factors, signaling molecules, and
epigenetic modifications. Despite its promise, BHB supplementation faces several challenges,
such as determining the optimal dosage, ensuring long-term safety, identifying the most effective
type and formulation, establishing biomarkers of response, and conducting cost-effectiveness analyses.
BHB supplementation opens exciting avenues for research, including investigating molecular
mechanisms, refining optimization strategies, exploring innovation opportunities, and assessing
healthspan and lifespan benefits. BHB supplementation represents a new frontier in health research,
offering a potential pathway to enhance well-being and extend lifespan.
Neurotrophins in Peripheral Neuropathy: Exploring Pathophysiological Mechanisms and Emerging Therapeutic Opportunities
Authors: Samaddar Suman , Redhwan Moqbel Ali Moqbel , Eraiah Mohan Muttanahally , Koneri Raju
Published: September 2024

Neuropathies, which encompass a wide array of peripheral nervous system disorders,
present significant challenges due to their varied causes, such as metabolic diseases, toxic exposures,
and genetic mutations. This review article, focused on the critical role of neurotrophins in
peripheral neuropathy, highlights the intricate balance of neurotrophins necessary for nerve health
and the pathophysiological consequences when this balance is disturbed. Neurotrophins, including
Nerve Growth Factor (NGF), Brain-Derived Neurotrophic Factor (BDNF), Neurotrophin-3 (NT-
3), and Neurotrophin-4 (NT-4), are essential for neuronal survival, axonal growth, and synaptic
plasticity. Their signaling pathways are crucial for maintaining peripheral nervous system integrity,
primarily via the Tropomyosin receptor kinase (Trk) receptors and the p75 neurotrophin receptor
p75(NTR). Dysregulation of neurotrophins is implicated in various neuropathies, such as diabetic
neuropathy and chemotherapy-induced peripheral neuropathy, leading to impaired nerve
function and regeneration. Understanding neurotrophin signaling intricacies and their alterations
in neuropathic conditions is crucial for identifying novel therapeutic targets. Recent advancements
illuminate neurotrophins' potential as therapeutic agents, promising disease-modifying treatments
by promoting neuronal survival, enhancing axonal regeneration, and improving functional recovery
post-nerve injury. However, translating these molecular insights into effective clinical applications
faces challenges, including delivery methods, target specificity, and the instability of protein-
based therapies.
Development of Quality Standard and a Comprehensive Quality Control Study of Bharngyadi Kvatha Churna: An Ayurvedic Formulation
Authors: Narasimhaji Cheemalapati Venkata , Kurra Siva Durga , Bolleddu Rajesh , Marimuthhu Gokul , Dighe Dattatray , Ghandi Yashika , Kumar Vijay , Ghosh Debomitha , Das Manosi , Rao Meda M. , Das Debajyoti , Singh Ravindra , Babu Gajji , Srikanth Narayanam , Acharya Rabinarayan
Published: September 2024

Background:

Bharngyadi Kvatha Churna (BKC) is an important polyherbal formulation
mentioned in the Ayurvedic Formulary of India (AFI) for the treatment of intermittent fever
and chronic fever but lacks the presence of standardised quality control parameters.

Aims:

The aim of the present study was to develop a quality standard of BKC and to carry out a
comprehensive quality control study, including the evaluation of physicochemical parameters,
safety parameters, elemental content, secondary metabolites, and selected phytochemical analysis.

Methods:

In HPTLC analysis, piperlongumine was quantified in BKC using a silica gel-coated
aluminium plate and developing solvent of toluene: acetone (6:4 v/v). In HPLC analysis, piperine
was quantified using acetonitrile: water (80: 20 v/v) mobile phase, and ellagic acid was quantified
using water (0.05% KH2PO4): acetonitrile (70: 30 v/v) mobile phase. ICP-OES was used to determine
elemental content. The estimation of secondary metabolites like total sugars, tannins,
flavonoids, alkaloids, and saponins was also carried out using a UV-Vis spectrophotometer. The
volatiles present in the volatile oil of BKC were analysed using the gas chromatography-mass
spectrometry technique.

Results:

The physicochemical parameters namely, loss on drying, total ash, acid-insoluble ash, alcohol-
soluble extractive, water-soluble extractive, pH (10% aq. susp.), and volatile oil ranged
from 10.56% to 11.06%, 4.67% to 5.76%, 0.73% to 1.78%, 7.56% to 8.2%, 12.04% to 13.06%,
5.87% to 5.96%, and 0.091% to 0.097%, respectively. The amount of piperlongumine in BKC
ranged from 0.7688 mg/g to 0.9902 mg/g. The amount of piperine and ellagic acid ranged from
0.1180% to 0.1362% and 0.0016% to 0.0034%, respectively. Oleyl alcohol is the major volatile
phytochemical present in BKC.

Conclusions:

The developed standardised quality control parameters of BKC would aid the herbal
industry in developing BKC with requisite quality.
Potential Probiotic Yeasts Isolated from Idli and Selroti, Indian Ethnic Fermented Cereal-based Foods
Authors: Rai Aakriti , Lama Sonam , Das Souvik , Thatal Bipashna , Tamang Jyoti Prakash
Published: September 2024

Introduction:

In the present study, we focused on the screening of the potential probiotic
yeasts isolated from two Indian fermented cereal-based foods, viz., idli and selroti. A total of 260
yeast isolates were isolated from the batters of idli (140 isolates) and selroti (120 isolates).

Methods:

Preliminary screening of basic probiotic traits such as tolerance to low pH, bile, and cell
surface attachment was checked for the selection of potential probiotic yeasts from total isolates.
Finally, 8 yeast isolates were selected for further in-depth assessment by in vitro and genetic screening,
which included Clavispora lusitaniae AIY-4, Wickerhamomyces anomalus MIY-30, Pichia
kudriavzevii BIY-8 (from idli), Yarrowia lipolytica SGLY-15, Y. lipolytica SGLY-21, Candida parapsilosis
SPRY-17, C. parapsilosis SBRY-12, and Kodamaea ohmeri SBRY-25 (from selroti).

Results:

A principal component analysis (PCA) biplot was designed to evaluate the differences and
similarities amongst the yeast strains, and two clusters were formed using the paired group (UPGMA)
algorithm and Euclidean similarity index. Cluster one was comprised of Cl. lusitaniae AIY-
4, W. anomalus MIY-30, C. parapsilosis SBRY-12, and P. kudriavzevii BIY-8, and another cluster
included C. parapsilosis SBRY-12 and Y. lipolytica SGLY-21.

Conclusion:

Hence, based on statistical analysis for probiotic in vitro and genetic screening, Wickerhamomyces
anomalus MIY-30 (idli) and Kodamaea ohmeri SBRY-25 (selroti) were selected as
the most potential probiotic strains.
Leveraging Generative AI for Drug Safety and Pharmacovigilance
Authors: Mishra Hara Prasad , Gupta Rachna
Published: September 2024

Predictions are made by artificial intelligence, especially through machine learning,
which uses algorithms and past knowledge. Notably, there has been an increase in interest in using
artificial intelligence, particularly generative AI, in the pharmacovigilance of pharmaceuticals under
development, as well as those already in the market. This review was conducted to understand
how generative AI can play an important role in pharmacovigilance and improving drug safety
monitoring. Data from previously published articles and news items were reviewed in order to obtain
information. We used PubMed and Google Scholar as our search engines, and keywords
(pharmacovigilance, artificial intelligence, machine learning, drug safety, and patient safety) were
used. In toto, we reviewed 109 articles published till 31st January 2024, and the obtained information
was interpreted, compiled, evaluated, and conclusions were reached. Generative AI has transformative
potential in pharmacovigilance, showcasing benefits, such as enhanced adverse event detection,
data-driven risk prediction, and optimized drug development. By making it easier to process
and analyze big datasets, generative artificial intelligence has applications across a variety of
disease states. Machine learning and automation in this field can streamline pharmacovigilance
procedures and provide a more efficient way to assess safety-related data. Nevertheless, more investigation
is required to determine how this optimization affects the caliber of safety analyses. In
the near future, the increased utilization of artificial intelligence is anticipated, especially in predicting
side effects and Adverse Drug Reactions (ADRs).
Pengaruh Kualitas Produk Dan Periklanan Terhadap Minat Pembelian Ulang
Authors: Meirinta Larissa Apsarini , Isharina Ikhtiara Kaideni
Published: September 2024

Viva Cosmetics is one of the popular local cosmetic brands in Indonesia, Under PT Vitapharm, the products started to be marketed in 1962. Since 2021, the market share of the company has decreased, and this condition is not the company’s vision. Therefore, it needs strategies to increase the number of consumers, one of them is by enhancing their repurchase intention. The objective of this research is to identify the effects of product quality and advertisement on the repurchase intention of Viva Cosmetics’ consumers in Java. This quantitative explanatory research elucidates the causal relationship between its variables through hypothesis testing. From the infinite population of all Viva Cosmetics Consumers in Java, 140 females with the minimum age of eighteen years who live in Java and have at least made one purchase of the brand’s product since 2022 were selected as the sample through non-probability sampling method. This study uses multiple linear regression analysis. The results indicate that product quality positively and significantly influences the repurchasing intention of people in Java and that advertisement has no significant effect on the said intention.
 
Abstrak
Viva Cosmetics merupakan salah satu merek produk kecantikan lokal ternama di Indonesia yang sudah berdiri sejak 1962 oleh PT Vitapharm. Berdasarkan data survei, merek ini mengalami penurunan pangsa pasar sejak 2021 sampai sekarang yang tidak sesuai dengan visinya. Oleh karena itu dibutuhkan strategi untuk meningkatkan konsumen dan salah satunya dengan melakukan analisis minat pembelian ulang. Penelitian ini bertujuan untuk mengetahui pengaruh kualitas produk dan periklanan terhadap minat pembelian ulang produk Viva Cosmetics di Pulau Jawa. Penelitian ini menggunakan pendekatan kuantitatif dengan jenis penelitian eksplanatori, yaitu menjelaskan hubungan kausal antara variabel melalui pengujian hipotesis. Populasi penelitian ini adalah seluruh konsumen Viva Cosmetics di Pulau Jawa dengan jumlah infinit. Teknik pengambilan sampel yang digunakan adalah non-probabilitas sebanyak 140 sampel dari populasi yang ada, dengan sampel wanita berusia minimal delapan belas tahun yang berdomisili di Pulau Jawa dan pernah membeli produk Viva Cosmetics minimal satu kali sejak tahun 2022. Penelitian ini menggunakan analisis regresi linier berganda. Berdasarkan hasil penelitian yang dilakukan, dapat disimpulkan bahwa kualitas produk memiliki pengaruh positif signifikan sedangkan periklanan tidak berpengaruh signifikan terhadap minat pembelian ulang produk Viva Cosmetics di Pulau Jawa.
An Evidence-Based Nurse-Led Intervention to Reduce Diabetes Distress Among Adults With Type 1 Diabetes and Diabetes Distress (REDUCE): Development of a Complex Intervention Using Qualitative Methods Informed by the Medical Research Council Framework
Authors: Stenov Vibeke , Cleal Bryan , Willaing Ingrid , Christensen Jette Normann , Jensen Christian Gaden , Mouritsen Julie Drotner , Due-Christensen Mette
Published: September 2024

Background

Diabetes distress refers to the negative emotional reaction to living with the demands of diabetes; it occurs in >40% of adults with type 1 diabetes (T1D). However, no interventions to reduce diabetes distress are specifically designed to be an integral part of diabetes care.

Objective

This study aims to modify and adapt existing evidence-based methods into a nurse-led group intervention to reduce diabetes distress among adults with T1D and moderate to severe diabetes distress.

Methods

The overall framework of this study was informed by the initial phase of the Medical Research Council’s complex intervention framework that focused on undertaking intervention identification and development to guide the adaptation of the intervention. This study took place at 2 specialized diabetes centers in Denmark from November 2019 to June 2021. A total of 36 adults with T1D participated in 10 parallel workshops. A total of 12 diabetes-specialized nurses were interviewed and participated in 1 cocreation workshop; 12 multidisciplinary specialists, including psychologists, educational specialists, and researchers, participated in 4 cocreation workshops and 14 feedback meetings. Data were analyzed by applying a deductive analytic approach.

Results

The intervention included 5 biweekly 2.5-hour small group sessions involving adults with T1D and diabetes distress. Guided by a detailed step-by-step manual, the intervention was delivered by 2 trained diabetes specialist nurses. The intervention material included visual conversation tools covering seven diabetes-specific sources derived from the 28-item Type 1 Diabetes Distress Scale for measuring diabetes distress: (1) powerlessness, (2) self-management, (3) fear of hypoglycemia, (4) food and eating, (5) friends and family, (6) negative social perception, and (7) physician distress. The tools are designed to kick-start awareness and sharing of diabetes-specific challenges and strengths, individual reflections, as well as plenary and peer-to-peer discussions about strategies to manage diabetes distress, providing new perspectives on diabetes worries and strategies to overcome negative emotions. Diabetes specialist nurses expressed a need for a manual with descriptions of methods and detailed guidelines for using the tools. To deliver the intervention, nurses need increased knowledge about diabetes distress, how to support diabetes distress reduction, and training and supervision to improve skills.

Conclusions

This co-design study describes the adaptation of a complex intervention with a strong evidence base, including detailed reporting of the theoretical underpinnings and core mechanisms.
Development Trends and Prospects of Technology-Based Solutions for Health Challenges in Aging Over the Past 25 Years: Bibliometric Analysis
Authors: Liu Lu , Wang Xiu-Ling , Cheng Nuo , Yu Fu-Min , Li Hui-Jun , Mu Yang , Yuan Yonghui , Dong Jia-Xin , Wu Yu-Dan , Gong Da-Xin , Wang Shuang , Zhang Guang-Wei
Published: September 2024

Background

As the global population ages, we witness a broad scientific and technological revolution tailored to meet the health challenges of older adults. Over the past 25 years, technological innovations, ranging from advanced medical devices to user-friendly mobile apps, are transforming the way we address these challenges, offering new avenues to enhance the quality of life and well-being of the aging demographic.

Objective

This study aimed to systematically review the development trends in technology for managing and caring for the health of older adults over the past 25 years and to project future development prospects.

Methods

We conducted a comprehensive bibliometric analysis of literatures related to technology-based solutions for health challenges in aging, published up to March 18, 2024. The search was performed using the Web of Science Core Collection, covering a span from 1999 to 2024. Our search strategy was designed to capture a broad spectrum of terms associated with aging, health challenges specific to older adults, and technological interventions.

Results

A total of 1133 publications were found in the Web of Science Core Collection. The publication trend over these 25 years showed a gradual but fluctuating increase. The United States was the most productive country and participated in international collaboration most frequently. The predominant keywords identified through this analysis included “dementia,” “telemedicine,” “older-adults,” “telehealth,” and “care.” The keywords with citation bursts included “telemedicine” and “digital health.”

Conclusions

The scientific and technological revolution has significantly improved older adult health management, particularly in chronic disease monitoring, mobility, and social connectivity. The momentum for innovation continues to build, with future research likely to focus on predictive analytics and personalized health care solutions, further enhancing older adults’ independence and quality of life.
Effects of Image Degradation on Deep Neural Network Classification of Scaphoid Fracture Radiographs (Preprint)
Authors: Lin Chihung , Yoon Alfred P. , Wang Chien-Wei , Chung Kevin C. , Kuo Chang-Fu
Published: September 2024

UNSTRUCTURED

This study evaluated the performance of a deep learning model trained to detect scaphoid fractures in radiographs when various perturbations were added to the images. The datasets were modified by applying Gaussian noise; via blurring, JPEG compression, contrast-limited adaptive histogram equalization (CLAHE), and resizing; and the addition of geometric offsets. Model accuracy declined as the severity of perturbations increased; however, the extent of performance decline varied according to the type of perturbation. The model demonstrated greater resistance to color perturbations than to grayscale perturbations, but the application of Gaussian blur exerted a considerably negative impact on model performance. CLAHE increased the false-positive rate. There was a strong linear relationship between image quality and model performance; the model performed better on higher-quality images. We also found that geometric offset or pixel value rescaling did not affect the performance of the deep learning model. Resolution was the most significant factor influencing model performance; localizing the region of interest may minimize any decrease in accuracy. Overall, this study provides insights into the robustness of deep learning models that detect small fractures, such as scaphoid fractures, in radiographs subjected to various perturbations. The findings could guide the development of more accurate models for medical image analysis. The cumulative insights gained from this study will contribute to the design of more accurate and robust deep learning models tailored for medical image analysis, especially under conditions of varying image quality.
Free-Living Physical Activity in Youth (FLPAY): Study Protocol and Methods (Preprint)
Authors: LaMunion Samuel Robert , Hibbing Paul Robert , Crouter Scott Edward
Published: September 2024

BACKGROUND

Wearable activity monitors are increasingly used to characterize physical behavior. Development and validation of these characterization methods requires criterion labelled data typically collected in a lab or simulated free-living environment, which does not generally translate well to free-living due to limited behavior engagement in development that is not representative of free-living.

OBJECTIVE

The Free-Living Physical Activity in Youth (FLPAY) study was designed in two parts to establish a criterion dataset for novel method development for identifying periods of transition between activities in youth.

METHODS

The FLPAY study utilized criterion measures of behavior (direct observation) and energy expenditure (indirect calorimetry) to label data from research-grade devices for the purpose of developing and cross-validating models to identify transitions, classify activity type, and estimate energy expenditure in youth ages 6-18 years old. The first part of the study was a simulated free-living protocol in the lab, comprising short (roughly 60-90 s) and long (roughly 4-5 min) bouts of 16 activities that were completed in various orders over the span of two visits. The second part of the study involved an independent sample of participants who agreed to be measured twice (2 hours each time) in free-living environments such as the home and community.

RESULTS

The FLPAY study was funded in June 2016 and concluded in March 2020. Data collection is complete.

CONCLUSIONS

The two-part design of the FLPAY study emphasized collection of naturalistic behaviors and periods of transition between activities in both structured and unstructured environments. This filled an important gap considering the traditional focus on scripted activity routines in laboratory environments. This protocol paper details the FLPAY procedures and participants, along with details about criterion datasets, which will be useful in future studies analyzing the wealth of device-based data in diverse ways.
Large Language Models for Self-Diagnosis: A New Front for Medical Information (Preprint)
Authors: Zada Troy , Tam Natalie , Barnard Francois , Rambhatla Sirisha , Bhat Venkat
Published: September 2024

BACKGROUND

Rapid integration of Large Language Models (LLMs) in healthcare is sparking global discussion about their potential to revolutionize healthcare quality and accessibility. At a time where improving healthcare quality and access remains a critical concern for countries worldwide, the ability of these models to pass medical exams has been used to argue in favour of their use in medical training and diagnosis. However, the impact of their inevitable use as a self-diagnostic tool and their role in spreading healthcare misinformation has not been evaluated.

OBJECTIVE

This study aims to assess the effectiveness of LLMs from the perspective of a general user self-diagnosing to better understand the clarity, accuracy, and robustness of the models.

METHODS

We develop a comprehensive testing methodology based on a medical licensing exam to evaluate LLM responses to open-ended questions to mimic real-world use cases.

RESULTS

We reveal that a) ChatGPT-4.0 is marked as being correct 36% of the time by non-experts and experts, with only 34% agreement between them. Interestingly, b) when prompted with sentence dropout on the correct responses from a), non-experts tend to rate 27% additional responses as correct, which indicates an increased risk of spreading medical misinformation.

CONCLUSIONS

These results highlight the modest capabilities of LLMs since their responses are often unclear and inaccurate. A need exists to call the community to develop trustworthy solutions to reduce medical misinformation in LLMs.
Tổng hợp vật liệu rắn Zr MOF xúc tác phân hủy Polyethylene Terephthalate
Authors: Nguyễn Bùi Thị Quế Trân , Nguyễn Minh Thy , Nguyễn Hải Hiểu , Nguyễn Phương Duy , Diệp Lê Hà Thơ , Nguyễn Thị Tuyết Nhung
Published: September 2024

Vật liệu khung lai hóa hữu cơ ‑ kim loại được tổng hợp thành công trong nghiên cứu dựa trên tâm kim loại zirconium (Zr‑MOF) từ muối zirconium tetrachloride (ZrCl4) và linker terephthalic acid (H2BDC) trong dung môi N,N‑dimethylformamide (DMF) ở 120°C. Cấu trúc của vật liệu được xác định bằng phương pháp nhiễu xạ tia X dạng bột (PXRD) và hình thái được quan sát bằng kính hiển vi điện tử quét (FE‑SEM). Thành phần nguyên tố trong cấu trúc cũng được phân tích bằng phổ tán xạ năng lượng tia X (EDS). Vật liệu có độ bền nhiệt cao được xác định qua phân tích nhiệt trọng lượng (TGA). Vật liệu Zr‑MOF tạo thành có khả năng xúc tác phản ứng phân hủy polyethylene terephthalate (PET) thành terephthalic acid (TA) trong 24 giờ ở 260°C.
Tổng quan ứng dụng liên kết Canxi-Alginate trong màng composite và vật liệu giả da Bioleather
Authors: Nguyễn Ngọc Như Ý , Nguyễn Thanh Phương , Tạ Hữu Nhân , Lư Trần Tú My , Phạm Thị Ngọc Nga
Published: September 2024

Gel của Ca-alginate trong nước được ứng dụng nhiều trong vật liệu màng composite với nhiều ứng dụng linh hoạt đã được nhiều nhà khoa học phát hiện ra. Bên cạnh đó, xu hướng sử dụng vật liệu da thân thiện môi trường đã phát triển rất nhiều ở các nước trên thế giới. Bài báo này nhằm cung cấp những thông tin về vật liệu màng composite và vật liệu giả da Bioleather dựa trên liên kết ion gel của Ca- Alginate trong môi trường nước.
Xác định ngưỡng chịu mặn của cừu (Ovis aries) Phan Rang khi cho uống nước biển pha loãng
Authors: Nguyễn Thiết , Nguyễn Thanh Đạt , Nguyễn Trọng Ngữ
Published: September 2024

Thí nghiệm nhằm đánh giá ngưỡng chịu mặn của cừu (Ovis aries) và được thực hiện trên 10 cừu đực, chia thành 2 giai đoạn. Giai đoạn 1 cho  cừu uống nước ngọt trong 7 ngày từ hai máng uống giống nhau. Giai đoạn 2 trong 8 ngày cho cừu uống nước ngọt cho máng uống thứ nhất và nước biển pha loãng (DSW) cho máng uống thứ hai hoặc ngược lại, nồng độ DSW (diluted seawater) từ 0,5% đến 2,0%. Kết quả cho thấy khối lượng cơ thể và lượng chất khô ăn vào không khác nhau bởi DSW, trong khi lượng nước uống vào cao hơn ở giai đoạn 2 (P<0,05). Cừu uống nhiều DSW ở nồng độ 0,5% và sau đó giảm sự lựa chọn DSW ở nồng độ 1,0%, tránh lựa chọn DSW ở nồng độ 1,5% và từ chối uống ở nồng độ 2,0%. Cừu uống DSW tăng nồng độ natri và clorua huyết tương, trong khi đó kali huyết tương không khác nhau giữa giai đoạn 1 và 2. Nồng độ urê, creatine, AST và ALT huyết tương không thay đổi giữa hai giai đoạn. Kết quả thí nghiệm cho rằng cừu có thể chịu đựng được DSW lên tới 1%.
An Analysis of the Vocabulary List Arrangement in Primary School English Textbooks from the Perspective of Frame Semantics
Authors: Xie Ziying
Published: September 2024

With the increasingly close ties between countries all over the world, the acquisition of English as a second language is particularly important, in which English vocabulary learning is crucial. But the way of vocabulary arrangement and presentation affects students’ vocabulary memorization effect to a great extent. As the starting stage for students to learn English, the problem of teaching vocabulary in elementary school is worth pondering. Based on the Frame Semantics Theory, this paper examines the arrangement of vocabulary lists in elementary school English textbooks by taking the first book of the fourth-grade English textbook published by Foreign Language Teaching and Research Publishing House as an example. It is found that the new words in the vocabulary lists of the current textbooks are simply arranged in the order that they appear in the text or in alphabetical order, which is inconsistent with students’ cognition. Therefore, we believe that based on the Frame Semantics Theory, a reasonable arrangement of vocabulary and the provision of a frame vocabulary list in line with the students’ cognition can enable students to spend the less cognitive effort to obtain more cognitive effect, and achieve twice the result with half the effort.
Development of Quality Agriculture Practices as a Pillar of Sustainable Agro-Production for Fighting Against Hunger
Authors: Khanal Uttam
Published: September 2024

Our main concern is agriculture production. The high-quality productions are absent due to some technical issues. The standards criteria for inspections are prepared to help each production grow. It aims to reduce adverse impacts on both the environment and human health. Safeguard the environment and preserve healthy agricultural produce; all depend heavily on agricultural practices. The soil, water, disease, pests, and climate change are important elements for agricultural practices. Attributes of natural cycles developed to maintain biological variety are preserved by sustainable agriculture. The sustainable farming practices are the research question to ask farmers. The responses are crop cycle 8.90%, crop diversity 12.83%, protecting crops/seed 12.57%, integrating paste management 10.73%, attracting beneficial organisms 12.30%, soil fertility 14.92%, animal grazing 15.71%, and water management 12.04%, respectively. This is important to analyze. Similarly, techniques like crop rotation, conservation tillage, and pasture-based animal husbandry are the cornerstones of sustainable agriculture. It does not rely on activities that harm soil, water, or other natural resources. Using excessive fertilizer, hazardous pesticides, or genetically engineered seeds is very serious. It includes raising animals, producing food and vegetables. In addition is providing wholesome food for families and communities, farmers that employ sustainable agriculture practices preserve water, soil, and seeds. The sustainable farming process produces healthy food without harming future generations’ ability to use their land in the same way. It produces clean, fresh, nutritious products and increases the market to improve the economic condition of farmers.
Analysis of the Chinese Translation of Sister Carrie from a Feminist Perspective
Authors: Wang Shanshan
Published: September 2024

Women and translators have had similar experiences and status in social history, both traditionally being in a position of weakness within their respective hierarchical structures. Feminist Translation Theory challenges this inherent bias, aiming to eliminate the stereotypical images of women in society and disrupt the “flattened female images” in translated versions of classic works, successfully representing female subjectivity and gender identity. Currently, the widely accepted translation strategies of supplementation, prefaces and footnotes, and “hijacking” best reflect contemporary women’s discourse power and female consciousness awakening. This article examines the translated version of the feminist-colored novel Sister Carrie, exploring how translators, from a feminist translation perspective, can coexist with the original work while restoring many unique and nuanced female images for readers.
Coronavirus (CoV) proteins in GtoPdb v.2024.2
Authors: Alexander Stephen P.H. , Ball Jonathan K. , Tsoleridis Theocharis
Published: September 2024

Coronaviruses are large, often spherical, enveloped, single-stranded positive-sense RNA viruses, ranging in size from 80-220 nm. Their genomes and protein structures are highly conserved. Three coronaviruses have emerged over the last 20 years as serious human pathogens: SARS-CoV was identified as the causative agent in an outbreak in 2002-2003, Middle East respiratory syndrome (MERS) CoV emerged in 2012 and the novel coronavirus SARS-CoV-2 emerged in 2019-2020. SARS-CoV-2 is the virus responsible for the infectious disease termed COVID-19 (WHO Technical Guidance 2020).
Hydrolases & Lipases in GtoPdb v.2024.2
Authors: Alexander Stephen P.H. , Doherty Patrick , Fairlie David , Fowler Christopher J. , Overall Christopher M. , Rawlings Neil , Southan Christopher , Turner Anthony J.
Published: September 2024

Listed in this section are hydrolases not accumulated in other parts of the Concise Guide, such as monoacylglycerol lipase and acetylcholinesterase. Pancreatic lipase is the predominant mechanism of fat digestion in the alimentary system; its inhibition is associated with decreased fat absorption. CES1 is present at lower levels in the gut than CES2 (P23141), but predominates in the liver, where it is responsible for the hydrolysis of many aliphatic, aromatic and steroid esters. Hormone-sensitive lipase is also a relatively non-selective esterase associated with steroid ester hydrolysis and triglyceride metabolism, particularly in adipose tissue. Endothelial lipase is secreted from endothelial cells and regulates circulating cholesterol in high density lipoproteins.