bluuebunny/crossref_metadata_2025 huggingface dataset:
Elevated expression of TUBA1C in breast cancer predicts poor prognosis
Authors: Zhao Yi , Wang Wenwen , Li Jinming , Du Jiarui , Xie Qiqi , Wang Miaozhou , Liu Zhen , Huo Xingfa , Zhao Fuxing , Ren Dengfeng , Zhao Jiuda , Shen GuoShuang
Published: November 2023

α1C-tubulin (TUBA1C) is a member of the α-tubulin family and has served as a potential biomarker in a variety of cancers in many studies. In this study, the gene expression profile of TUBA1C in The Cancer Genome Atlas (TCGA) was extracted for analysis, and the prognostic value of TUBA1C in breast cancer was comprehensively evaluated. The Wilcoxon signed-rank test, Kruskal-Wallis test, and logistic regression analysis were performed to confirm the correlations between TUBA1C expression and the clinical characteristics of breast cancer patients. The effect of TUBA1C expression on the survival of breast cancer patients was assessed by Kaplan-Meier curve, Cox regression analysis, and the Kaplan-Meier plotter (an online database). The TCGA data set was used for the Gene Set Enrichment Analysis (GSEA). The results confirmed that high TUBA1C expression in breast cancer was closely correlated with survival time, survival status, and tumor size. In addition, elevated TUBA1C expression can predict poor overall survival (OS), recurrence-free survival (RFS), and distant metastasis-free survival (DMFS). Univariate and multivariate analyses (Cox regression analyses) confirmed that TUBA1C was an independent prognostic factor for the OS of breast cancer patients. The GSEA identified that the high TUBA1C expression phenotype was differentially enriched in cell cycle, basal transcription factor, P53 signaling pathway, pathways in cancer, TOLL-like receptor signaling pathway, and NOD-like receptor signaling pathway. In summary, high messenger RNA (mRNA) expression of TUBA1C is an independent risk factor for poor prognosis of breast cancer.
Effects of parental migration on early childhood development of left-behind children in Bangladesh: Evidence from a nationally representative survey
Authors: Khanam Shimlin Jahan , Khan Md Nuruzzaman
Published: November 2023

Background

In Bangladesh, as in other low- and middle-income countries, parents frequently migrate to other areas, often for employment opportunities, leaving their children behind with the hope that their earnings will contribute to securing a better future for them. However, the absence of parents due to migration can have negative implications for the well-being of these left-behind children. Despite the existence of studies investigating this phenomenon, the evidence thus far has produced inconclusive findings, with no specific data available from Bangladesh. Therefore, the objective of this study was to examine the effects of parental migration on the early childhood development of left-behind children in Bangladesh.

Methods

The present study utilized data from the Bangladesh Multiple Indicator Cluster Survey (MICS) conducted in 2019. A sample of 8,833 children aged 3–4 years was included in the analysis. The Early Childhood Development Index (ECDI) and its individual domains served as the outcome variables of interest. The primary explanatory variables considered in the analysis were father migration, mother migration, migration of both parents, and migration of either parent. To assess the association between the outcomes and explanatory variables, multilevel logistic regression analysis was employed, controlling for relevant covariates.

Results

Approximately 29% of all children in the study were not developmentally on track, as measured by the ECDI. When examining the individual domains of the ECDI, only 9% of the total children demonstrated developmental progress in the learning domain. Regarding the association between parental migration and ECDI outcomes, we observed a 26% decrease in the likelihood of overall ECDI among children with a migrated father (OR: 0.74, 95% CI: 0.54–0.93). This decrease became even more pronounced, reaching 37% (OR: 0.63, 95% CI: 0.48–0.97), among children with both parents migrated, compared to children with neither parent migrated.

Conclusion

The findings of this study indicate that parental migration, especially when both parents are involved, has a substantial negative impact on the likelihood of achieving favourable ECDI outcomes for children in Bangladesh. To ensure the optimal development of children with migrating parents, it is crucial to strengthen early childhood development education programs and implement robust social safety nets. These efforts should specifically target the unique needs and challenges faced by children with migrated parents, providing them with the necessary support and resources for their holistic development.
A study of the economic growth effects of market integration: An examination of 27 cities in the Yangtze River Delta city cluster
Authors: Yang Jing
Published: November 2023

The city cluster of the Yangtze River Delta is a highly dynamic and competitive economic region in China. The integration of the market across the 27 cities is crucial in driving economic growth in the area. This paper aims to provide policymakers with recommendations on promoting regional integration, enhancing the structure, and improving overall performance. By utilizing the benefits and resources of each community more effectively, greater economic gains can be achieved. The findings of this study can also be applied to other Chinese towns or business areas. Market integration is a necessary foundation for regional integration, as it enables the seamless movement of goods and factors throughout the region while simultaneously reducing entry barriers and supporting the creation of a unified market. Unfortunately, the "vassal economy" model has impeded the region’s economic growth. The integration of regional markets is crucial for economic growth. However, it is equally important to create industrial clusters with central towns as their hubs. The Yangtze River Delta urban agglomeration is a prime example of one of six world-class city clusters demonstrating how market integration can result in high-quality economic progress. The paper’s primary discoveries are threefold: firstly, there has been a progressive elevation in the level of market integration among the 27 cities within the Yangtze River Delta city cluster, characterized by increasingly intimate connections concerning trade, investment, and population mobility. Secondly, this heightened market integration exerts a catalytic impact on the real economic growth of the Yangtze River Delta city cluster, particularly concerning regional industrial restructuring, transformation, and upgrading. Finally, market integration is poised to expedite the industrial division of labor and synergistic development between the cities, thus promoting a concentration of advanced manufacturing and new industries in the central cities and furthering the development of profitable industries in the central individual cities.
Validity of the models predicting 10-year risk of cardiovascular diseases in Asia: A systematic review and prediction model meta-analysis
Authors: Nomali Mahin , Khalili Davood , Yaseri Mehdi , Mansournia Mohammad Ali , Ayati Aryan , Navid Hossein , Nedjat Saharnaz
Published: November 2023

We aimed to review the validity of existing prediction models for cardiovascular diseases (CVDs) in Asia. In this systematic review and meta-analysis, we included studies that validated prediction models for CVD risk in the general population in Asia. Various databases, including PubMed, Web of Science conference proceedings citation index, Scopus, Global Index Medicus of the World Health Organization (WHO), and Open Access Thesis and Dissertations (OATD), were searched up to November 2022. Additional studies were identified through reference lists and related reviews. The risk of bias was assessed using the PROBAST prediction model risk of bias assessment tool. Meta-analyses were performed using the random effects model, focusing on the C-statistic as a discrimination index and the observed-to-expected ratio (OE) as a calibration index. Out of 1315 initial records, 16 studies were included, with 21 external validations of six models in Asia. The validated models consisted of Framingham models, pooled cohort equations (PCEs), SCORE, Globorisk, and WHO models, combined with the results of the first four models. The pooled C-statistic for men ranged from 0.72 (95% CI 0.70 to 0.75; PCEs) to 0.76 (95% CI 0.74 to 0.78; Framingham general CVD). In women, it varied from 0.74 (95% CI 0.22 to 0.97; SCORE) to 0.79 (95% CI 0.74 to 0.83; Framingham general CVD). The pooled OE ratio for men ranged from 0.21 (95% CI 0.018 to 2.49; Framingham CHD) to 1.11 (95%CI 0.65 to 1.89; PCEs). In women, it varied from 0.28 (95%CI 0.33 to 2.33; Framingham CHD) to 1.81 (95% CI 0.90 to 3.64; PCEs). The Framingham, PCEs, and SCORE models exhibited acceptable discrimination but poor calibration in predicting the 10-year risk of CVDs in Asia. Recalibration and updates are necessary before implementing these models in the region.
Transforming medical device biofilm control with surface treatment using microfabrication techniques
Authors: Al Bataineh Mohammad T. , Alazzam Anas
Published: November 2023

Biofilm deposition on indwelling medical devices and implanted biomaterials is frequently attributed to the prevalence of resistant infections in humans. Further, the nature of persistent infections is widely believed to have a biofilm etiology. In this study, the wettability of commercially available indwelling medical devices was explored for the first time, and its effect on the formation of biofilm was determined in vitro. Surprisingly, all tested indwelling devices were found to be hydrophilic, with surface water contact angles ranging from 60° to 75°. First, we established a thriving Candida albicans biofilm growth at 24 hours. in YEPD at 30°C and 37°C plus serum in vitro at Cyclic olefin copolymer (COC) modified surface, which was subsequently confirmed via scanning electron microscopy, while their cellular metabolic function was assessed using the XTT cell viability assay. Surfaces with patterned wettability show that a contact angle of 110° (hydrophobic) inhibits C. albicans planktonic and biofilm formation completely compared to robust growth at a contact angle of 40° (hydrophilic). This finding may provide a novel antimicrobial strategy to prevent biofilm growth and antimicrobial resistance on indwelling devices and prosthetic implants. Overall, this study provides valuable insights into the surface characteristics of medical devices and their potential impact on biofilm formation, leading to the development of improved approaches to control and prevent microbial biofilms and re-infections.
Multiple-Criteria Decision-Making (MCDM) techniques to study the behavior of dendrimers using topological indices
Authors: Zuo Xuewu , Akhtar Maryam , Aslam Adnan , Tawfiq Ferdous M. , Kanwal Salma
Published: November 2023

Topological indices provide a mathematical language for capturing molecular structure, symmetry, and predicting properties. Dendrimers are microscopic bilaterally symmetrical molecules with a well-defined homogeneous nanoparticles structure, often consisting of a symmetric center, inner shell, and outer shell. In this work, first we compute some degree-based topological indices of Porphyrin (DnPn),Poly (Propyl) Ether Imine(PETIM), Zinc porphyrin (DPZn), and Polyamidoamine (PAMAM) dendrimers. Then, we use multi-criteria decision making (MCDM) techniques to establish the weighted evaluation of dendrimer classes based on certain topological indices. For weighted analysis we correlate the properties of benzene derivatives with topological invariants. Finally, based on the multi-criteria decision making techniques namely TOPSIS, SAW and MOORA method, we have ranked the dendrimer structures based on their properties.
Auxiliary self-supervision to metric learning for music similarity-based retrieval and auto-tagging
Authors: Akama Taketo , Kitano Hiroaki , Takematsu Katsuhiro , Miyajima Yasushi , Polouliakh Natalia
Published: November 2023

In the realm of music information retrieval, similarity-based retrieval and auto-tagging serve as essential components. Similarity-based retrieval involves automatically analyzing a music track and fetching analogous tracks from a database. Auto-tagging, on the other hand, assesses a music track to deduce associated tags, such as genre and mood. Given the limitations and non-scalability of human supervision signals, it becomes crucial for models to learn from alternative sources to enhance their performance. Contrastive learning-based self-supervised learning, which exclusively relies on learning signals derived from music audio data, has demonstrated its efficacy in the context of auto-tagging. In this work, we propose a model that builds on the self-supervised learning approach to address the similarity-based retrieval challenge by introducing our method of metric learning with a self-supervised auxiliary loss. Furthermore, diverging from conventional self-supervised learning methodologies, we discovered the advantages of concurrently training the model with both self-supervision and supervision signals, without freezing pre-trained models. We also found that refraining from employing augmentation during the fine-tuning phase yields better results. Our experimental results confirm that the proposed methodology enhances retrieval and tagging performance metrics in two distinct scenarios: one where human-annotated tags are consistently available for all music tracks, and another where such tags are accessible only for a subset of music tracks.
The impact of brand trust on consumers’ behavior toward agricultural products’ regional public brand
Authors: Liu Qiyun , Wang Xinyuan
Published: November 2023

The importance of agricultural products’ regional public brands, owned by relevant organizations and jointly used by several agricultural production and operation entities, is increasing in contemporary marketing research. Based on a survey of 544 consumers, this study investigates the influence of brand trust, attitude, subjective norms, and perceived behavioral control on their purchase intention and behavior toward agricultural products’ regional public brand. Through SEM, we find that brand trust toward agricultural products’ regional public brand positively influences consumer attitude, purchase intention, and purchase behavior. In addition, attitude and purchase intention mediate the relationship between brand trust and purchase behavior. While attitude and perceived behavioral control positively affect purchase intention, no similar effect is found for subjective norms. Moreover, multigroup invariance tests demonstrate that consumer behavior can be influenced by factors such as gender, age, monthly income, marital status, previous visits to the region, and purchase purpose. We therefore recommend that to bolster competitiveness, regional public brand stakeholders maintain agricultural product quality, ensure reliable purchasing and transportation channels, and enhance brand trust.
Evaluation of the diagnostic performance of EpiTuub® Fecal Rotavirus Antigen Rapid Test Kit in Amhara National Regional State, Ethiopia: A multi-center cross-sectional study
Authors: Damtie Debasu , Gelaw Aschalew , Wondimeneh Yitayih , Aleka Yetemwork , Tarekegn Zewdu Siyoum , Sack Ulrich , Vlasova Anastasia N. , Tessema Belay
Published: November 2023

Rotavirus is the leading cause of morbidity and mortality due to acute gastroenteritis among children under five years globally. Early diagnosis of rotavirus infection minimizes its spread and helps to determine the appropriate management of diarrhea. The aim of this study was to evaluate the performance of EpiTuub® Fecal Rotavirus Antigen Rapid Test Kit for the diagnosis of rotavirus infection among diarrheic children under five years in Ethiopian healthcare settings. A total of 537 children with diarrhea were enrolled from three referral hospitals in Amhara National Regional State, Ethiopia. The samples were tested using one-step RT-PCR and EpiTuub® Fecal Rotavirus Antigen Rapid Test Kit (KTR-917, Epitope Diagnostics, San Diego USA) in parallel. Diagnostic performance of the rapid test kit was evaluated using the one-step RT-PCR as a gold standard. The sensitivity, specificity, and predictive values of the rapid test kit were determined. Moreover, the agreement of the rapid test kit with one step RT-PCR was determined by kappa statistics and receiver operators’ curve (ROC) analysis was done to assess the overall diagnostic accuracy of the rapid test kit. Fecal Rotavirus Antigen Rapid Test Kit has shown a sensitivity of 75.5% and specificity of 98.2%. The kit was also found to have 89.9% and 95.0% positive and negative predictive values, respectively. The Fecal Rotavirus Antigen Rapid Test Kit has shown a substantial agreement (78.7%, p = 0.0001) with one-step RT-PCR. The overall accuracy of the Fecal Rotavirus Antigen Rapid Test Kit was excellent with the area under the ROC curve of 86.9% (95% CI = 81.6, 92.1%) (p = .0001). Thus, Fecal Rotavirus Antigen Rapid Test is a sensitive, specific, user-friendly, rapid, and equipment-free option to be used at points of care in Ethiopian health care settings where resource is limited precluding the use of one step RT-PCR. Furthermore, the kit could be used in the evaluation and monitoring of rotavirus vaccine effectiveness in the aforementioned settings.
Relationship between the evaluation of agricultural scientific and technological innovation capacity and the influencing factors of green agriculture
Authors: Zhang Mei , Fang Kai , Zhang Danting , Zeng Dejie
Published: November 2023

China has limited arable land area, and its output value is increased with enhanced agricultural inputs such as machinery, irrigation, fertilizers, and pesticides. However, this mode is accompanied by an increase in agricultural carbon emissions. With the aim to further examine the driving effect of scientific and technological innovation on economic growth and green agriculture, this study uses the Solow growth model coupled with the Cobb–Douglas production function and vector autoregressive models. Then, the agricultural scientific and technological innovation capacity in Guangdong Province during 2006–2020 is evaluated by using the contribution rate of agricultural scientific and technological progress (ASTP) as the assessment index. In addition, the carbon footprints of green agricultural indexes such as machinery, irrigation, fertilizers, and pesticides are measured to analyze the relationship between green agriculture and agricultural scientific and technological innovation capacity. Results demonstrate the gradual increase in the contribution rate of ASTP in Guangdong Province. During the 11th, 12th, and 13th Five-Year Plan periods, the rates were 65.09%, 65.94%, and 70.40%, respectively, indicating that the agricultural scientific and technological innovation ability constantly improved. Among the indexes of green agriculture, the carbon footprints of machinery have a significant impact on agricultural scientific and technological innovation, which is quickly transformed into machinery. Such innovation requires the driving force of science and technology itself, which have relatively significant and rapid effects. On the basis of the results, corresponding policy suggestions are proposed: increasing investments in scientific and technological innovation in the agricultural field, vigorously developing new energy-saving and emission reduction products and processes for fertilizers, and increasing the research and promotion of agricultural machinery. The proposed method provides good prospects for the development of agricultural production towards mechanization, intelligence, efficiency, and greenness.
Multidrug-resistant and carbapenemase-producing critical gram-negative bacteria isolated from the intensive care unit environment in Amhara region, Ethiopia
Authors: Kindu Mizan , Moges Feleke , Ashagrie Degu , Tigabu Zemene , Gelaw Baye
Published: November 2023

Background

Intensive care units are units where healthcare-associated infections (HAIs) are common and antimicrobial resistance rates are increasing. Microbial contamination in hospital environment plays an important role in the development of HAIs. Intervention-based improvements in infection prevention and control at national and facility level are critical for the containment of antimicrobial resistance and prevention of HAIs.

Objectives

This study aimed to determine the distribution of multidrug-resistant and carbapenemase-producing critical gram negative bacteria (Klebsiella pneumoniae, Escherichia coli, Pseudomonas aeruginosa and Acinetobacter species) and their antibiotic resistance in intensive care unit environmental surfaces at the University of Gondar and Felege Hiwot Comprehensive Specialized Hospitals.

Methods

This was multicenter hospital-based cross sectional study. Environmental samples were swabbed from all intensive care units using a normal saline moistened-sterile cotton tip stick. Bacteria culturing and antibiotic susceptibility testing were performed following standard microbiological techniques. Selected meropenem-resistant isolates were phenotypically assessed for carbapenemase production using modified and simplified carbapenem inactivation methods.

Results

From a total of 384 environmental samples analyzed, 126 (32.8%) showed growth and 162 isolates were identified. K. pneumoniae (79/162, 48.8%) was the commonest isolate followed by Acinetobacter species (51/162, 31.5%), E. coli (19/162, 11.7%) and P. aeruginosa (13/162, 8.0%). Multidrug-resistant and carbapenemase-producing isolates were detected on most hospital environment surface types, especially from the baby bed sets and incubators. The most common multidrug-resistant and principal carbapenemase producer was K. pneumoniae, with rates of 71(89.9%) and 24(85.7%), respectively.

Conclusion

This study revealed the distribution of multidrug-resistant and carbapenemase-producing critical gram negative bacteria in the environment of intensive care unit. Higher detection rate of multidrug-resistant and carbapenemase-producing K. pneumoniae on most environmental surfaces calls for urgent control action and further attention.
A katonai szakmai angol nyelvvizsgák és a nyelvi képzés jellemzői és eredményei a hazai kadétképzésben
Authors: Fábián Gyöngyi , Kopházi-Molnár Erzsébet
Published: November 2023

A NATO egyik hivatalos nyelve az angol nyelv, így a katonai műveletekben részt vevő magyar katonák sikeres működéséhez is nélkülözhetetlennek tűnik az ezen a nyelven szerzett használható szakmai nyelvtudás, amelyet Magyarországon két szakmai nyelvvizsga, az ARMA és a NATO STANAG 6001 is mér. Munkánkban elsőként a két vizsga hasonló és eltérő jellemzőire fordítjuk figyelmünket a szóbeli kommunikációt központba helyező szóbeli vizsgarész tekintetében, amelyet a vizsgadokumentumok adatelemzésével végzünk el. A továbbiakban a katonai szaknyelv oktatásával, valamint az általános vagy szaknyelvi nyelvvizsga sikeres teljesítésével kapcsolatos hazai tapasztalatok feltárásával foglalkozó vizsgálatunk azt kutatja, történik-e szakmai angol nyelvű oktatás a kadétképzésben, és ha igen, milyen módon, melyik típusú intézményekben és milyen hatékonysággal. A kadétoktatásban részt vevő nyelvtanárok (N = 25) körében végzett kérdőíves felmérés eredménye alapján megállapítható, hogy az iskolai nyelvi képzést többnyire angol nyelvű középszintű érettségire (KER B1 szint) való felkészítés jellemzi a HKP I. és a HKP II. programban résztvevő iskolákban. A szakmai nyelvvizsga iránti érdeklődés ugyan jelen van, de az azzal kapcsolatos ismeretek, valamint az oktatásban erre a célra fejlesztett tananyagok felhasználása is meglehetősen hiányos. Még azok a kadétok is, akik a HKP III. programban tanulnak, és nyelvvizsgát tesznek, főként általános (tehát nem szakmai anyaggal bővített) nyelvvizsgára készülnek.
ISSUES OF THE STRUCTURAL ORGANIZATION OF LIGNIN AND PROSPECTS FOR ITS PROCESSING
Authors: Kozhevnikov Aleksandr Yur'yevich , Shestakov Semen Leonidovich , Sypalova Yuliya Aleksandrovna
Published: November 2023

In this article, we represented the review of literature data about the study of lignin as one of the most abundant biopolymers. The review is based on the articles published in the most quoted world publishing. It is noted that already nowadays the lignin is considered as a powerful renewable source of valuable organic raw materials, also it’s pointed that potential possibilities of lignin valorization are much wider than those are used in present times. The special attention is paid to the structure and molecular organization of birch lignin, which wood is actively utilized in chemical industry, meanwhile the hardwood lignins are less studied in literature than softwood lignins. The authors touched the most basic methods of research of such complex and irregular polymer as lignin, methods’ advantages, disadvantages and perspectives are analyzed. It is noted that nowadays the most effective methods of lignin structure units study are pyrolisys gas chromatography and nuclear magnetic resonance. The article describes various ways of lignins isolation from the wood, and influence of the isolation way on the structure of isolated substance. Also, the structural features of birch lignin and its differences from other species are shown.
Assessment of Cardiac Dysfunctions in Patients with Liver Cirrhosis Admitted in a Tertiary Care Centre
Authors: Kasthuri Ramachandran Pillai  , Selvarajan Chettiar K. P.  , Suresh M. K.
Published: November 2023

BACKGROUND

The presence of cardiovascular dysfunction in liver cirrhosis has been studied over the past several years. Cardiovascular dysfunctions in cirrhosis increase the risk of coronary artery disease and mortality after TIPSS insertion and liver transplantation. Cirrhotic cardiomyopathy also plays an important role in the pathogenesis of hepatorenal syndrome. All these data highlight the need for rigorous cardiovascular risk assessment in patients with liver cirrhosis.

METHODS

After obtaining institutional approval, we analysed 96 consenting patients with liver cirrhosis satisfying inclusion criteria. Relevant history of the cases was sought through a structured questionnaire. Appropriate clinical examinations were done. Echocardiogram, ECG and biochemical parameters of the patients were examined and recorded. Data analysis was done using SPSS software.

RESULTS

51% of the patients had QTc > 0.44 seconds in ECG which was suggestive of electrophysiological abnormality. The systolic dysfunction was assessed by presence of left ventricular ejection fraction below 55%, which was detected in 4.2% of the patients. E/A ratio less than 1 and deceleration time more than 200 msec were taken as parameters suggestive of the presence of diastolic dysfunction. 34.4% had an E/A ratio < 1 and 42.7% of the patients had a deceleration time more than 200 msec. 53% were found to have cirrhotic cardiomyopathy. The prevalence of CCM was increasing with the severity of liver disease. 53.1% of the patients had left ventricular hypertrophy and there was significant association between the prevalence of LVH and severity of cirrhosis. 38.5% of the patients had coronary artery disease as per history and ECG findings. No significant association was obtained between the prevalence of CAD and severity of CLD. 4.2% patients had arrhythmia and there was a significant association with the severity of disease. Troponin I was elevated in 20.8% of the patients.

CONCLUSIONS

Liver cirrhosis is a risk factor for cardiovascular dysfunctions. Most of the patients with cardiac compromise were asymptomatic. 53% patients were diagnosed to have cirrhotic cardiomyopathy. The prevalence of cardiovascular dysfunctions was found to increase with the rising severity of cirrhosis as per CTP score. Diastolic dysfunction was more prevalent than systolic dysfunction. The prevalence of cardiovascular dysfunctions was lesser among patients with regular follow-up and treatment for cirrhosis liver. 38.5% of the patients had coronary artery disease. The prevalence of arrhythmias was 4.2%. Troponin levels were elevated in 20.8% patients.
Benedetti G. M., et al. (2022). Pioneras en geografía. Mujeres en la docencia e investigación en las carreras de Geografía de Universidades Argentinas
Authors: Thiébaut Virginie
Published: November 2023

Benedetti G. M., et al. (2022). Pioneras en geografía. Mujeres en la docencia e investigación en las carreras de Geografía de Universidades Argentinas. Editorial de la Facultad de Filosofía y Letras, Universidad de Buenos Aires. 88 p. ISBN: 978-987-8927-35-0
Analysis of Student's Misconceptions in Static and Dynamic Electricity Physics Using the Three Tier Test
Authors: Nawanda De Gupita  , Alya Rahma Yanti  , Nur Untoro
Published: November 2023

Physics is one of the subjects that is considered difficult, this assumption is reinforced by students who experience misconceptions, some even do not understand the concept. This study aims to find out students' misconceptions about static electricity and dynamic electricity. The research method is qualitative, with research subjects consisting of 20 students from class XII. The test instrument used consisted of 10 static and dynamic electricity questions self-made with content validation results of 0.96, empirical validity of 1.01, and reliability of 0.8 using the three-tier test method. The data collection techniques used in the form of tests. The results of the study showed that 33.5% of students experienced misconceptions, the value was categorized as moderate. Meanwhile, 29.5% did not understand the concept and 35% understood the concept. Although the level of misconception is categorized as moderate, it still has to be an evaluation.
MIXED-INTEGER MODEL OF INFORMATION RESOURCES SECURITY CONTROL IN THE CORPORATE INFORMATION ENVIRONMENT
Authors: Buryak Yu. I. , Skrynnikov A. A.
Published: November 2023

The problem of developing a fast algorithm for calculating options for choosing the best composition of information resource protection in a corporate information system is considered. The necessary composition of models has been formed, including: threats, vulnerabilities, means of protection and destruction of the resource. It is assumed that the damage to the resource is determined by the joint action of threats and means of protection, while the sequence of application of individual threats does not matter for assessing the total value. The harmfulness of threats and the effectiveness of protection tools are described within the framework of a probabilistic model. A criterion for choosing the optimal set of protections is proposed. The criteria for forming a decision on reconfiguration and restructuring of the corporate information system are consistently considered. It is shown that the present problem relates to difficult combinatorial optimization problems, that is, there is no general polynomial algorithm for it that allows to obtain a solution in polynomial time. However, taking into account the specifics of the task, in some cases, allows you to build calculation schemes that provide sufficient accuracy of the solution and an acceptable time. The following calculation schemes are considered: the search for alternative options by sorting through threats, by means of protection, as well as a sequential search of a variety of means of protection. The effectiveness of each scheme was evaluated based on the number of iteration options. A fast algorithm has been developed for calculating the best protection option based on an ordered search of subsets of protections, and the minimum set of protections that covers all threats is used as the initial set. The results of calculations are presented and the possibility of a sharp reduction in the time of computational procedures is shown.
PENTINGNYA SIKAP BIJAK DALAM BERMEDIA SOSIAL
Authors: Sudarsih Sri , Widisuseno Iriyanto
Published: November 2023

Pengabdian masyarakat ini konsentrasi pada urgensi sikap bijaksana dalam menggunakan media sosial bagi pengemudi becak pariwisata di Yogyakarta. Media sosial merupakan salah satu media yang dapat menunjang pengembangan pariwisata di Yogyakarta. Metode yang digunakan dalam pengabdian masyarakat ini adalah sosialisasi dan diskusi interaktif. Sosialisasi ditujukan agar para pengemudi becak memahami mengenai sikap bijak dalam bermedia sosial. Diskusi interaktif bertujuan agar lebih mudah memahami materi dan realisasinya dalam masyarakat. Media sosial merupakan suatu sarana yang dapat dimanfaatkan untuk sarana berkomunikasi. Sikap bijak bermedia sosial yang seharusnya ditunjukkan oleh pengemudi becak adalah media sosial seharusnya menjadikan seseorang semakin memahami makna hidupnya, mampu menyelesaikan persoalan hidupnya dengan bijaksana, memahami orang lain dengan berempati, dan mengedepankan integritas, sikap dan tingkah lakunya selalu mencerminkan nilai-nilai etika yang mendasari setiap aspek hidupnya. Integritas harus dijaga karena menentukan kualitas seseorang. Kata kunci: bijak, media sosial, pariwisata, pengemudi becak  This community service focuses on the urgency of being wise in using social media for tourist pedicab drivers in Yogyakarta. Social media is one of the media that can support tourism development in Yogyakarta. The methods used in this community service are socialization and interactive discussions. The outreach is intended so that pedicab drivers understand wise attitudes in using social media. The interactive discussion aims to make it easier to understand the material and its realization in society. Social media is a tool that can be used as a means of communication. The wise attitude in using social media that should be shown by rickshaw drivers is that social media should make a person understand the meaning of his life more, be able to solve his life problems wisely, understand other people with empathy, and prioritize integrity, his attitudes and behavior always reflect the underlying ethical values. every aspect of his life. Integrity must be maintained because it determines a person's quality.Keywords: wise, social media, tourist, rickshaw driver
Optimised feature selection-driven convolutional neural network using gray level co-occurrence matrix for detection of cervical cancer
Authors: Sudhakar K. , Saravanan D. , Hariharan G. , Sanaj M. S. , Kumar Santosh , Shaik Maznu , Gonzales Jose Luis Arias , Aurangzeb Khursheed
Published: November 2023

Cervical cancer is one of the most dangerous and widespread illnesses afflicting women throughout the globe, particularly in East Africa and South Asia. In industrialised nations, the incidence of cervical cancer has consistently decreased over the past few decades. However, in developing countries, the reduction in incidence has been considerably slower, and in some instances, the incidence has increased. Implementing routine screenings for cervical cancer is something that has to be done to protect the health of women. Cervical cancer is famously difficult to diagnose and cure due to the slow rate at which it spreads and develops into more advanced stages of the disease. Screening for cervical cancer using a Pap smear, more often referred to as a Pap test, has the potential to detect the illness in its earlier stages. For the purpose of selecting features for this article, a gray level co-occurrence matrix (GLCM) technique was used. Following this step, classification is performed with methods such as convolutional neural network (CNN), support vector machine, and auto encoder. According to the findings of this experiment, the GLCM-CNN classifier proved to be the one with the highest degree of precision.
Antibacterial, antifungal, antioxidant, and cytotoxicity activities of the aqueous extract of Syzygium aromaticum-mediated synthesized novel silver nanoparticles
Authors: Muruganandham Moorthy , Al-Otibi Fatimah Oleyan , Alharbi Raedah Ibrahim , Sivasubramanian Kanagasabapathy , Raja Ramalingam Karthik , Velmurugan Palanivel , Basavegowda Nagaraj
Published: November 2023

The synthesis of silver nanoparticles using plant-based materials has seen a surge in recent years. This study used the Syzygium aromaticum (clove) buds extract as a reducing agent for synthesizing silver nanoparticles (Sa-AgNPs). The presence of Sa-AgNPs (440 nm) was confirmed by UV-Vis spectroscopy. The optimization of nanoparticle production with pH, metal ions, and substrate concentration (clove extract) was studied. The transmission electron microscopy analysis revealed that Sa-AgNPs had a size distribution predominantly below the range of 10–100 nm. The investigation of Sa-AgNPs using EDX revealed the presence of an optical absorption silver peak at 3 keV. The involvement of phenolic chemicals and carboxylic acids in stretching O–H, N–O, and C═O bonds, forming Sa-AgNPs has been identified by Fourier transform infrared spectroscopy. Klebsiella pneumoniae and Trichophyton rubrum exhibited a higher inhibition zone of 26 ± 0.48 mm and 21 ± 0.48 mm in antibacterial and antifungal activity, respectively. In the 2,2-diphenyl-1-picrylhydrazyl experiment, at a maximum concentration of 500 μg·mL−1, Sa-AgNPs exhibited a scavenging efficiency of 79.98%. Cytotoxicity was observed in the treated cells due to the presence of biologically synthesized Sa-AgNPs. An IC50 value of 48 μg·mL−1 was determined by treating L929 human fibroblast cells.
SRI-30827, a novel allosteric modulator of the dopamine transporter, alleviates HIV-1 Tat-induced potentiation of cocaine conditioned place preference in mice
Authors: Hammond Haylee R. , Eans Shainnel O. , Cirino Thomas J. , Ananthan Subramaniam , Jimenez-Torres Ana Catya , Zhu Jun , McLaughlin Jay P.
Published: November 2023

Objectives

HIV-1 Tat (transactivator of transcription) protein disrupts dopaminergic transmission and potentiates the rewarding effects of cocaine. Allosteric modulators of the dopamine transporter (DAT) have been shown to reverse Tat-induced DAT dysfunction. We hypothesized that a novel DAT allosteric modulator, SRI-30827, would counteract Tat-induced potentiation of cocaine reward.

Methods

Doxycycline (Dox)-inducible Tat transgenic (iTat-tg) mice and their G-tg (Tat-null) counterparts were tested in a cocaine conditioned place preference (CPP) paradigm. Mice were treated 14 days with saline, or Dox (100 mg/kg/day, i.p.) to induce Tat protein. Upon induction, mice were place conditioned two days with cocaine (10 mg/kg/day) after a 1-h daily intracerebroventricular (i.c.v.) pretreatment with SRI-30827 (1 nmol) or a vehicle control, and final place preference assessed as a measure of cocaine reward.

Results

Dox-treatment significantly potentiated cocaine-CPP in iTat-tg mice over the response of saline-treated control littermates. SRI-30827 treatment eliminated Tat-induced potentiation without altering normal cocaine-CPP in saline-treated mice. Likewise, SRI-30827 did not alter cocaine-CPP in both saline- and Dox-treated G-tg mice incapable of expressing Tat protein.

Conclusions

These findings add to a growing body of evidence that allosteric modulation of DAT could provide a promising therapeutic intervention for patients with comorbid HIV-1 and cocaine use disorder (CUD).
Mesolithic Occupations During the Boreal Climatic Fluctuations at La Baume de Monthiver (Var, France)
Authors: Ricci Giulia , Audiard Benjamin , Tomasso Antonin , Hoareau Leïla , Julien Marie-Anne , Mologni Carlo , Purdue Louise , Porraz Guillaume
Published: November 2023

The Mesolithic technology in Western Europe depicts the last cultural expressions and adaptations of hunter-gatherers before the adoption of Neolithic agro-pastoral practices. Many questions arise when investigating the timing, nature, and historical significance of the Mesolithic. The development of the Mesolithic culture is usually associated with the onset of milder environmental conditions at the beginning of the Holocene. Hunter-gatherer societies would have adopted new subsistence and territorial strategies in response to environmental changes, which would have consecutively impacted their technological system. This assertion considers the Mesolithic in South-western Europe as one homogeneous phenomenon and eludes the putative role that early Holocene climatic fluctuations may have played in hunter-gatherer organizations. In this study, we aimed at questioning the archaeological variability of the first Mesolithic by taking benefit from new data provided by recent excavations at La Baume de Monthiver (Comps-sur-Artuby, France). La Baume de Monthiver is a small rock shelter located along the Jabron Valley in the southern French pre-Alps. The rock shelter records several Mesolithic occupations documenting Sauveterrian technological traditions. By studying the Baume de Monthiver, we take the opportunity to explore the Sauveterrian in itslongue duréeand address the question of its diachronic variability. In this study, we investigated the M-B′ archaeological assemblage and question its homogeneity at the transition of the 10th- and 9th-millennium cal. BP. Our results document stable technological and subsistence practices before and after the climatic fluctuations at the end of the 10th-millennium cal. BP, supporting the hypothesis of well-adapted Mesolithic societies to the climatic “instability” characterizing the early Holocene.
Wotan’s Biopunk: The Grim(m) German God and His English Bloodsport in Sarban’s The Sound of His Horn
Authors: Winthrop-Young Geoffrey
Published: November 2023

The essay analyzes Sarban’s 1952 novel The Sound of His Horn, one of the first alternate histories to depict a victorious Third Reich. The depiction of the latter is a strange mixture. On the one hand, the novel is a product of its day by presenting a regressive, resolutely anti-modern Nazi Germany headed back into a barbarian past. On the other hand, it anticipates later depictions (both in the alternate history genre as well as in historiography proper) by highlighting the constitutive role of technology and the regime’s inner divisions. The latter results in narrowing the gap between the (British) observer and his (German) environment. I argue that this narrowing can be traced by analyzing both the chief villain Hackelnberg, a figure borrowed from German folklore that Jacob Grimm associated with the Germanic god Wotan, and the key motif of hunting. Second, the narrowing is structurally embedded in the novel by virtue of the fact that the counterfactual Nazi domain is confined to a nested narrative. It may be a mere projection, in which case Hackelnberg’s deadly hunts and English bloodsports are not that far apart.
Featural Representation and Internal Noise Underlie the Eccentricity Effect in Contrast Sensitivity
Authors: Xue Shutian , Fernández Antonio , Carrasco Marisa
Published: November 2023

Human visual performance for basic visual dimensions (e.g., contrast sensitivity and acuity) peaks at the fovea and decreases with eccentricity. The eccentricity effect is related to the larger visual cortical surface area corresponding to the fovea, but it is unknown if differential feature tuning contributes to this eccentricity effect. Here, we investigated two system-level computations underlying the eccentricity effect: featural representation (tuning) and internal noise. Observers (both sexes) detected a Gabor embedded in filtered white noise which appeared at the fovea or one of four perifoveal locations. We used psychophysical reverse correlation to estimate the weights assigned by the visual system to a range of orientations and spatial frequencies (SFs) in noisy stimuli, which are conventionally interpreted as perceptual sensitivity to the corresponding features. We found higher sensitivity to task-relevant orientations and SFs at the fovea than that at the perifovea, and no difference in selectivity for either orientation or SF. Concurrently, we measured response consistency using a double-pass method, which allowed us to infer the level of internal noise by implementing a noisy observer model. We found lower internal noise at the fovea than that at the perifovea. Finally, individual variability in contrast sensitivity correlated with sensitivity to and selectivity for task-relevant features as well as with internal noise. Moreover, the behavioral eccentricity effect mainly reflects the foveal advantage in orientation sensitivity compared with other computations. These findings suggest that the eccentricity effect stems from a better representation of task-relevant features and lower internal noise at the fovea than that at the perifovea.
Living in a global environmental emergency ward – the need to address problems with science, action and speed
Authors: Wells Peter G.
Published: November 2023

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Strategi Pengembangan Ekowisata Gunung Api Purba Nglanggeran Sebagai Penunjang Pertumbuhan Ekonomi di Gunungkidul Yogyakarta
Authors: Saripurnadinata Ronny
Published: November 2023

Dari kekayaan alam flora dan kondisi geografis Indonesia memiliki berbagai potensi ekowisata.Salah satu daerah Indonesia yang memiliki destinasi ekowisata yang cukup banyak terdapat di Daerah Istimewa Yogyakarta, tepatnya di Gunungkidul.Ekowisata Gunung Api Purba yang terletak di Desa Nglanggeran termasuk dalam destinasi wisata Gunungkidul yang menjadi bagian dari Gunung Sewu.Banyaknya potensi di Desa Nglanggeran untuk dikembangkan menjadi  destinasi pariwisata yang tidak hanya bertujuan pada Gunung api purba saja. Pengelolaan pariwisata dan kurangnya strategi mengakibatkan tidak berkembangnya industri pariwisata khususnya Ekowisata Gunung api purba Nglanggeran. Pengelolaan yang tepat dan informai yang lengkap dapat meningkatkan industri pariwisata dan dapat peningkatkan pertumbuhan perekonomian terutama di Kabupaten Gunungkidul.Maka harus diciptakan ide baru dalam pengembangan Ekowisata.Mengingat masih rendahnya SDM, lapangan usaha berbasis pengelolaan sumberdaya alam, pertanian, kehutanan, perikanan, dan lingkungan hidup khususnya dalam bentuk ekowisata.pentingnya konservasi keanekaragaman hayati dan budaya lokal. Dengan adanya strategi pengembangan ekowisata dapat memberikan pendapatan untuk kegiatan konservasi dan keuntungan ekonomi bagi masyarakat yang tinggal di sekitar lokasi ekowisata Gunung Api Purba Nglanggeran.
Analisis Analisis Pelaksanaan Program Asi Eksklusif di Posyandu
Authors: Harshindy Noviani Ade , Rahardjo Bambang Budi
Published: November 2023

Latar Belakang: ASI Eksklusif adalah Air Susu Ibu yang diberikan kepada bayi sampai bayi berusia 6 bulan tanpa diberikan makanan dan minuman, kecuali obat dan vitamin. Capaian pemberian ASI Eksklusif di Posyandu adalah 50% dari 80% target Progam ASI Eksklusif. Tujuan penelitian ini yaitu untuk mengatahui sejauhmana pelaksanaan Progam ASI Eksklusif di Posyandu Nusa Indah.

Metode: Penelitian ini merupakan penelitian kualitatif dengan pendekatan deskriptif yang berfokus pada pelaksanaan program ASI Eksklusif di Posyandu Nusa Indah. Instrumen yang digunakan adalah panduan wawancara mendalam, observasi, dan dokumentasi. Teknik analisis data menggunakan 3 langkah yaitu : reduksi data, penyajian data, dan penarikan kesimpulan.

Hasil: Hasil penelitian menunjukkan bahwa pelaksanaan program ASI Eksklusif di Posyandu Nusa Indah belum maksimal, dikarenakan SDM yang kurang dan pelatihan konselor tidak diadakan secara rutin, kurangnya sarana dan prasarana, kegiatan yang dilakukan belum optimal dikarenakan pemberdayaan petugas kurang dan informasi yang tidak merata.

Kesimpulan: Pelaksanaan program ASI Eksklusif di Posyandu Nusa Indah V belum berjalan dengan maksimal, saran untuk posyandu yaitu dengan penambahan petugas program ASI Eksklusif, melengkapi sarana prasarana, adanya penyuluhan dan konseling, dan dapat membentuk kelompok pendukung ASI agar cakupan ASI Eksklusif dapat meningkat.