bluuebunny/crossref_metadata_2025 huggingface dataset:
Analysis of the potential of modern information technology to manipulate response in education
Authors:   Bauman Moscow State Technical University, Butenko Iuliia I. , Marchenko Daniil E.
Published: July 2023

The article deals with the possibilities of modern information technologies for shaping the image of an educational institution, in particular, the problems associated with the capabilities of bot systems for automatic generation of reviews about the educational institution. It is shown that automatic generation of feedback on educational institutions is a means of manipulation in the educational environment. Strategies for shaping the image of an educational institution in the information space have been analyzed. It has been revealed that bot systems, adjusting to the dynamics of the struggle for image and recognition, as well as generating human-like reviews, form a disinformation environment in the educational environment. The paper also highlighted the reasons why people are susceptible to such manipulation and believe bot reviews, and substantiated why people to this day cannot reduce the impact of such manipulation by bot systems when choosing an educational institution. Examples of reviews generated by neural networks about higher education institutions are given.
The words гра́вер and гравёр as a result of interlingual contacts
Authors:   Komsomolsk-on-Amur State University, Shuneyko Alexander A. , Chibisova Olga V.
Published: July 2023

The relevance of the work lies in the fact that although the words гра́вер and гравёр have been actively used in the Russian language for three hundred years, today ortho-epic and explanatory dictionaries contain mutually exclusive evaluations of these words. That is, for three centuries their functioning has not been unambiguously established. There is every reason to believe that the cause for this is the specificity of interlingual contacts (German, English, Russian and French), which set different directions for the functionality and semantics of words. This study is aimed at clarifying the etymology of words, their semantic content and the nature of their use in speech. It is gradually revealed how the use of words is connected with the linguistic and cultural context, how it reflects interlingual contacts and captures the extralinguistic reality associated with the specifics of professional activity, with the predominant influence of one or another language on Russian and with the perception of one or another type of activity by the language community. From the analysis of the etymological, pragmatic and orthoepic characteristics of the units, it was concluded that гра́вер and гравёр are not variants of one word, but different words, approximately at the same time borrowed into Russian from different languages. Initially, these words were in a relationship of free variation, but gradually their meanings and uses were differentiated so much that now we can already talk about the establishment of a spontaneous speech norm. The word гравёр denotes a creative occupation, and the word гра́вер denotes a working profession.
Dissemination, use and transformation of A.V. Fedorov’s theory of translation in Chinese translation studies
Authors:   Shanghai International Studies University, Shizhang Yang , Qian Han
Published: July 2023

As the founder of linguistic translatology, A.V. Fedorov played an important role in the construction of not only Russian translatology but also Chinese translatology. This paper studies the travel of A.V. Fedorov’s translation theory in Chinese translatology, including its distribution, application and transformation. In the aspect of distribution, the author analyzes the translation of his representative work An Introduction to Translation Theory (1953) in China and the collection of his works in Chinese libraries. This paper also discusses the overall application of A.V. Fedorov’s translation ideas and the quotation of individual points of view. In terms of transformation, Chinese translation scholars have made a historical evaluation and development of his individual theoretical views.
The Сoncept “home-family” in the early works of Zhang Ailing (张爱玲, 1920–1995)
Authors:   Gorky Institute of World Literature of the Russian Academy of Sciences, Moshchenko Irina A.
Published: July 2023

This article presents a study designed to analyse the concept “home-family” in the early work of сhinese writer Zhang Ailing. The research shows the transformation of the concept and the way how new writers confronted the tradition in the first half of the 20th century. The idea of a patrilineal, hierarchical, patriarchal system, and the family as the basis of the world order were reassessed at the beginning of the 20th century. Participants of the May 4th movement severely criticized the old family system. In the works of “new women” writers Bing Xin and Ding Ling, the new semantic content of the concept “home-family” appears: the image of an ideal home in Bing Xin works transforms into Ding Ling’s fictional home of the childhood memories. The Zhang Ailing’s “home-family” concept presents a structure that is skewed to the one side. There is only one binary opposition (“warm” — “cold”) represented in the texts. All other meanings of the concept are marked negatively. Even if there is a pair of words that have opposite meanings, they complement each other rather than oppose each other. Combined together, the meanings of the “home-family” concept construct a hopeless, terrifying family image, which consists of obsession, illusory, fixation, instability, disappointment, indifference, moral injury, sacrifice, burden, fatigue, crampedness, emptiness, senseless.
Accidental approach, or “Memory of the genre”: Andrei Platonov’s story “The Cow” and Vladimir Narbut’s Easter story “Unexpected Joy”
Authors:   A.M. Gorky Literary Institute, Kozhukharov Roman R.
Published: July 2023

The article presents the experience of comparing A. Platonov’s story “The Cow” and V. Narbut’s Easter story “Unexpected Joy”. The presence of the gospel context, which is significant for both works, is found, among other things, at the level of the genre. Fixing the features of the Christmas and Easter stories allows us to correlate the analyzed texts with the prose of N. Leskov, F. Dostoevsky, A. Chekhov, M. Sholokhov in line with the concept of “memory of the genre” by M.M. Bakhtin.
The activities of the Society for the study of literature as a factor in the formation of realism in China
Authors:   Gorky Institute of World Literature of the Russian Academy of Sciences, Zakharova Natalia V.
Published: July 2023

The article analyzes the activities of the members of the “Society for the Study of Literature”, established in 1921 and up to the mid-30s determined the direction of development of Chinese literature. The Declaration of the Society reflected the views of both Chinese traditionalists, who defended the principles of Confucian literature, and those progressive writers who advocated the transition to new artistic techniques, which should include elements of realism, in particular, in “problem stories” — a new genre of modern Chinese literature. This genre has not yet become the subject of research by Russian sinologists, although Chinese literary critics have noted its role in the formation of modern Chinese literature. The task of identifying innovations in the genre of “problem prose” is solved by analyzing the stories of Bing Xin and Wang Tongzhao, members of the “Society for the Study of Literature”, who for the first time made the object of their attention the unsightly reality of contemporary Chinese society. The heroes of these works come from different social strata, they suffer to varying degrees when faced with the cruelty of the world around them, and find different ways to resist it. In “problem prose” we see a combination of styles of artistic and journalistic narration, strengthening the role of the author, life authenticity. As a result of the study, it was concluded that the gradual accumulation of new artistic elements in prose further contributed to the strengthening of realistic components in the narratives of Chinese writers.
Implementation of a Pilot Study to Analyze Circulating Tumor DNA in Early-Stage Lung Cancer
Authors: Espiga de Macedo Joana , Taveira-Gomes Tiago , Machado José Carlos , Hespanhol Venceslau
Published: July 2023

Introduction: Liquid biopsies based on plasma circulating tumour deoxyribonucleic acid (ctDNA) have shown promise in monitoring lung cancer evolution. The expression of ctDNA across time, its relationship with clinicopathological parameters and its association with lung cancer progression through imaging allow us to weigh how useful ctDNA could be in monitoring surgically resectable lung cancer. The aim of this study was to assess the impact of ctDNA analysis implementation in early-stage lung cancer.Methods: A cohort of 47 patients was sequentially recruited. Only 34 patients with early-stage lung cancer were included. All patients had a tissue specimen and five blood samples drawn: at the preoperative stage, from the pulmonary vein, at surgical discharge, at the first follow-up and at the last follow-up. All blood samples were evaluated for ctDNA expression. Results: On average, the maximum yield of ctDNA was obtained in liquid biopsies at the surgical discharge of patients when compared with PO, PV, and F1 (p < 0.0001, p < 0.0001, p < 0.0001 respectively). No statistically significant differences were found when comparing the last follow-up to surgical discharge ctDNA expression (p = 0.851). The correlation between ctDNA concentration according to five-time points and the four clinicopathological characteristics showed that patients younger than 70 years had a statistically significant reduction of the concentration of ctDNA at the preoperative and surgical discharge time point [β = -16 734 (-27 707; - 5760); p = 0.003; β = -21 785 (-38 447; -5123); p = 0.010], as opposed to an increase of the concentration of ctDNA at the pulmonary vein and last follow-up time points [β = 8369 (0.359; 16 378); p = 0.041; β = 34 402 (12 549; 56 254); p = 0.002] all with a confidence level of 95%. In the cases where actionable mutations were identified in tissue biopsies, the expected mutation was found in five out of six patients plasma samples at the pre-operatory time point and in two out of six patients plasma samples at the pulmonary vein time point. Two out of six patients with actionable mutations had disease progression.Conclusion: The results of this pilot study suggest that the maximum yield of ctDNA is obtained at the surgical discharge of the patients and that the pre-operatory timepoint is the one offering the highest sensitivity for the detection of actionable mutations in ctDNA in early-stage lung cancer.
Parents’ sense of coherence in the use of dental services by children aged 12 years old in the city Manaus/AM
Authors: Gomes Andressa Coelho , Silva Vivian Casanova da , Quadros Larissa Neves , Rebelo Maria Augusta Bessa , Rebelo Vieira Janete Maria
Published: July 2023

Aim: The aim of this study was to evaluate the association between the sense of coherence (SOC) of parents/guardians and the use of dental services by children who are 12 years old. Methods: This is a cross-sectional study conducted in the eastern zone of the city of Manaus, with 358 children enrolled in the 7th grade in the municipal public school system. Data collection was performed through self-administered questionnaires sent to parents/guardians, which contained questions about socioeconomic conditions, use of dental services by children and Antonovsky’s SOC-13 scale. Data were examined by descriptive and bivariate analysis, using the Chi-square test, with a 5% significance level. Results: Of the 358 children, 58.4% were female; in addition, 75.4% of the parents/guardians self-reported to be brown and 39.9% of them had a family income of ½ to 1 minimum wage. SOC was categorized as strong SOC and weak SOC by the median. The association between strong or weak SOC and the use of dental services in terms of frequency (p= 0.839) and reason for last visit (p= 0.384), was not significant. Conclusion: It was concluded that SOC of parents/guardians and utilization of dental services by children were not associated.
Sustentabilidade em cinco edificações residenciais utilizando o Selo Casa Azul
Authors: Reis Mari Aurora Favero , Minusculli Patrick , Reis Junior Paulo , Favretto Jacir
Published: July 2023

A contemplação do selo de sustentabilidade na construção civil impacta diretamente a qualidade de vida de seus ocupantes, a eficiência energética e a economia operacional da residência. Também, a certificação ambiental pode ser utilizada como instrumento de marketing para o imóvel, município e a qualidade do ambiente urbano. O Selo Casa Azul Caixa é um instrumento de classificação por intermédio de indicadores socioambientais para projetos de empreendimentos habitacionais, a fim de soluções mais eficientes no uso de recursos naturais e na melhoria da qualidade da habitação e de seu entorno. O objetivo foi aplicar indicadores de sustentabilidade do Selo Casa Azul Caixa (2010 e 2020), na avaliação de cinco edificações residenciais unifamiliares concluídas em 2020, na cidade de Concórdia, SC. A metodologia é do tipo qualitativa e quantitativa, utilizando como parâmetro os indicadores do guia Selo Casa Azul Caixa, organizados em seis categorias. Os resultados demonstraram que nenhuma das cinco residências obteve Selo Bronze, pois não atingiram todos os itens obrigatórios, padrão de sustentabilidade para ser certificada. A categoria mais bem avaliada foi a gestão eficiente da água e, a seguir, produção sustentável. As evidências possibilitam concluir sobre a probabilidade de não terem sido considerados os critérios para obtenção do selo no desenvolvimento dos projetos.
Shifts in the Employment Structure in Korea
Authors:   KOREA DEVELOPMENT ECONOMICS ASSOCIATION, Hong Minki
Published: July 2023

This study analyzes changes in the employment structure from 2000 to 2021 according to the job-based methodology. The results show that Employment in higher-paid jobs increased between 2000 and 2009. Employment polarization, on the other hand, emerged between 2009 and 2019. This study quantitatively identifies the labor demand and supply shocks using sign restrictions. The results show that the demand for high-income ICT and science and technology experts has increased significantly since 2000 suggesting that technology changes have had a significant impact. Deindustrialization, trade growth, and population aging had a significant impact on employment changes for low- and middle-income jobs. As the population ages rapidly in the 2010s, employment in health and social work services is increasing rapidly. In addition, changes in government policies related to non-regular workers and the expansion of the welfare system affected changes in employment type.
The impact of intra-party conflicts on the electoral performance of the All Basotho convention in Lesotho’s 2022 elections
Authors: Mofuoa Khali
Published: July 2023

The literature on Lesotho’s politics and political parties, particularly after 2012, focuses on their alliances and coalitions, their relationships with the military and the seemingly instability of coalitions. There is less focus on intra-party instability and its impact on political party electoral performance. This article uses a critical literature review to analyse the poor electoral performance of the All Basotho Convention (ABC) in the October 2022 elections and how this is a consequence of its internal conflicts. The ABC experienced intra-party conflicts that increased with the removal of its leader, Prime Minister Thomas Thabane, in 2020. The argument advanced in this article is that the ABC experienced a dramatic decline in electoral support in October 2022, with the drastic loss of forty seats, as a result of its internal conflicts. The party’s support had grown gradually since its formation in 2006 but dropped suddenly and dramatically in the 2022 elections. This article will contribute to the scholarship on the analysis of the electoral performance of political parties in the continent.
Another Approach to the Analysis of Isotropic Rectangular Thin Plates Subjected to External Bending Moments Using the Fourier Series
Authors: Fogang Valentin
Published: July 2023

The object of this paper is the analysis of isotropic rectangular thin plates supported (simply supported or clamped) along two opposite edges whereby the other edges have arbitrary support conditions; the plates are subjected to external bending moments, concentrated or distributed, and perpendicular to the supported edges. The standard approach to this problem is to replace the bending moment with a couple of forces infinitely close and to use the known expressions of efforts and deformations for the plate subjected to concentrated forces; the results are then related to the first derivatives of those efforts and deformations with respect to the position of application of the load. In this study, the external bending moment was expanded into a Fourier series, leading to a distributed external bending moment, and the boundary conditions and continuity equations were applied. Various types of rectangular plates were analyzed, as well as plates of infinite length whose results were identical to those in the literature. In addition, results for cantilever plates of infinite length were presented.
Pre-Clinical Models to Study Human Prostate Cancer
Authors: Thomsen Martin Kristian , Busk Morten
Published: July 2023

Prostate cancer is a common cancer among men and typically progresses slowly for several decades before becoming aggressive and spreading to other organs, leaving few treatment options. While large animals have been studied, the dog's prostate is anatomically similar to humans and has been used to study spontaneous prostate cancer. However, most research currently focuses on the mouse as a model organism due to the ability to genetically modify their prostatic tissues for molecular analysis. One hallmark in this research was the identification of the prostate-specific promoter Probasin, allowing for prostate-specific expression of transgenes. This has led to generations of mice with aggressive prostatic tumors through overexpression of the SV40 oncogene. The Probasin promoter is also used to drive Cre expression and allow researcher to generated prostate specific loss-of-function studies. Another landmark in the process of modeling prostate cancer in mice was orthoptic delivery of viral particles. This technology allows selective overexpression of oncogenes from lentivirus or the use of CRISPR to generate complex loss of function studies. These genetic modified models are complemented by classical xenografts of human prostate tumor cells in immune deficient mice. Overall, pre-clinical models have provided a portfolio of model systems to study and address complex mechanisms in prostate cancer for improved treatment options. This review will focus on the advances of each technique.
Opinion Dynamics Explain Price Formation in Prediction Markets
Authors: Restocchi Valerio , McGroarty Frank , Gerding Enrico , Brede Markus
Published: July 2023

Prediction markets are heralded as powerful forecasting tools, but models to describe them often fail to capture the full complexity of the underlying mechanisms that drive price dynamics. To address this issue, we propose a model in which agents belong in a social network, have an opinion about the probability of a particular event to occur, and bet on the prediction market accordingly. Agents update their opinions about the event by interacting with their neighbours in the network, following the Deffuant model of opinion dynamics. Our results suggest that a simple market model that takes into account opinion formation dynamics is capable to replicate the empirical properties of historical prediction market time series, including volatility clustering and fat-tailed distribution of returns. Interestingly, the best results are obtained when there is the right level of variance in the opinions of the agents. Moreover, this paper provides a new way to indirectly validate opinion dynamics models against real data by using historical data obtained from PredictIt, an exchange platform whose data has never been used before to validate models of opinion diffusion.
Thrombin Generation is Associated with Venous Thrombo-embolism Recurrence, but not with Major Bleeding and Death in the Elderly: A Prospective Multicenter Cohort Study
Authors: Vrotniakaite-Bajerciene Kristina , Rütsche Sereina , Calzavarini Sara , Quarroz Claudia , Stalder Odile , Méan Marie , Righini Marc , Staub Daniel , Beer Juerg H. , Frauchiger Beat , Österwalder Joseph , Kucher Nils , Matter Christian M. , Husmann Marc , Banyai Martin , Aschwanden Markus , Mazzolai Lucia , Hugli Olivier , Rodondi Nicolas , Aujesky Drahomir , Angelillo-Scherrer Anne
Published: July 2023

It is currently unknown whether thrombin generation is associated with venous thromboembolism (VTE) recurrence, major bleeding, and mortality in the elderly. Therefore, our aim was to prospectively study the association between thrombin generation and VTE recurrence, major bleeding and mortality in elderly patients with acute VTE. Consecutive patients aged ≥65years with acute VTE were followed for 2 years starting from 1 year after the index VTE. Primary outcomes were VTE recurrence, major bleeding and mortality. Thrombin generation was assessed in 565 patients 1 year after the index VTE. At this time, 59% of patients were still anticoagulated. Thrombin generation was discriminatory for VTE recurrence, but not for major bleeding and mortality in non-anticoagulated patients. Moreover, peak ratio (adjusted subhazard ratio 4.09, 95% CI, 1.12-14.92) and normalized peak ratio (adjusted subhazard ratio 2.18, 95% CI, 1.28-3.73) in presence/absence of thrombomodulin were associated with VTE recurrence, but not with major bleeding and mortality after adjustment for potential confounding factors. In elderly patients, thrombin generation was associated with VTE recurrence, but not with major bleeding and/or mortality. Therefore, our study suggests the potential usefulness of thrombin generation measurement after anticoagulation completion for VTE to help identifying among elderly patients those at higher risk of VTE recurrence.
Decamethylcyclopentasiloxane (D5) Should Not Be Considered Toxic to Reproduction
Authors: Scialli Anthony R.
Published: July 2023

not applicable
In Vitro and In Silico Analysis of Alpha-Amylase Inhibitory Activity of Ethanolic Extract of Adhatoda vasica Leaves
Authors: Yadav Chandrajeet Kumar , KC Sandhya , Thapa Shankar , Kandel Kamal , Shrestha Laxmi , Palikhey Anjan , Lamsal Ashish
Published: July 2023

Background: Diabetic patients are more likely to experience morbidity and mortality as a result of microvascular complications such as retinopathy, neuropathy, nephropathy, and stroke. There are many synthetic anti-diabetic agents available which are expensive and have undesirable pathological effects. Thus, it is essential to look for cost-effective, natural, and safe antidiabetic agents. The aim of this study was to screen phytoconstituent and evaluate the in-vitro and in-silico α-amylase inhibitory activity of ethanolic extract of Adhatoda vasica leaves. Method: The extraction of Adhatoda vasica leaves was performed with ethanol through Soxhlet extraction process. Different concentrations (0.1 mg/ml to 1 mg/ml) of ethanolic extract, Acarbose, and Sitagliptin, were prepared and all concentrations were evaluated for α-amylase inhibitory activity through the spectrophotometric method. Molecular docking (AutodockVina 1.2.0) and toxicity profiling (SToPToX web server) studies were performed. Results: The plant extract showed highest inhibition of α-amylase (56.763±0.0035) at a concentration of 1 mg/ml. This inhibitory activity was supported by the in-silico study. Vasicoline (C5) and quercetin (C9), active constitute of plant Adhatoda vasica, showed the best binding energy of 8.3 and 8.0 Kcal/mol respectively with α-amylase enzyme (PDBID: 4W93). Toxicity study revealed the safety profile of plant extract. Conclusion: It was concluded that Adhatoda vasica leaves possess some bioactive compounds which are responsible for controlling blood glucose levels and its identification, purification, and isolation may lead to the development of newer therapeutic agent with lesser side effects.
Prediction of Au-Associated Minerals in Eastern Thailand Based on Stream Sediment Geochemical Data Analysis by S-A Multifractal Model
Authors: Yaisamut Oraphan , Xie Shuyun , Charusiri Punya , Dong Jianbiao , Wen Weiji
Published: July 2023

Conducted within the scope of geochemical exploration in Eastern Thailand, this study aims to detect geochemical anomalies and potential mineral deposits. The objective was to interpret intricate spatial dispersion patterns and concentration levels of deposit pathfinder elements, specifically arsenic (As), copper (Cu), and zinc (Zn), using a comprehensive array of stream sediment geochemistry data. Methodologies involved integrating multifractal properties and traditional statistics, facilitated by the GeoDAS and ArcGIS platforms as instrumental analytical tools. In total, 5,376 stream sediment samples were collected and evaluated, leading to the development of an in-depth geochemical map. The results indicated distinct geological units marked by substantially elevated average values of the aforementioned elements. Identification of geochemical anomalies was achieved through the spatial distribution method and the subsequent application of the Spectrum-Area (S-A) multifractal model. An intriguing link was found between high As concentrations and gold deposits in the area, suggesting As as a viable pathfinder element for gold mineralization. The anomaly maps, generated from the stream sediment data, spotlighted potential zones of interest, offering valuable guidance for future mineral exploration and geological inquiries. Nonetheless, it is vital to recognize that the increased values noted in these maps may be influenced by regional geological factors, emphasizing the necessity for a diverse set of analytical methods for accurate interpretation. The study's significance lies in its pioneering use of the S-A multifractal model in geochemical data analysis. This innovative approach has deepened our comprehension of geochemical dispersion patterns and improved the precision of mineral exploration.
Current Challenges and Future Directions in the Management of Inflammatory Breast Cancer: A Review
Authors: Izzo Paolo , Izzo Luciano , Polistena Andrea , Sibio Simone , Codacci-Pisanelli Massimo , Crocetti Daniele , Meloni Paolo , Di Cello Pierfrancesco , De Intinis Claudia , Izzo Sara
Published: July 2023

(1) Background: Inflammatory breast cancer (IBC) is a rare and aggressive form of breast cancer that poses unique management challenges. This review aims to synthesize the current literature on IBC, focusing on diagnosis, treatment, and prognosis, while highlighting recent advances and ongoing issues in patient management.; (2) Methods: We outline the typical clinical presentation and diagnostic criteria of IBC. Additionally, we detail the main therapeutic strategies, including neoadjuvant chemotherapy, surgery, radiation therapy, targeted therapies, hormonal therapies, and emerging treatments such as immunotherapy. The review is based on a comprehensive analysis of the existing literature.; (3) Results: Despite advancements in systemic therapy and a better understanding of IBC biology, the prognosis for patients with IBC remains poor. The overall survival rate has shown only marginal improvement over the past few decades. Future research directions, including the identification of novel biomarkers for early detection and personalized medicine strategies, are identified. The need for more high-quality clinical trials to address the challenges in IBC management is emphasized.; (4) Conclusions: Managing IBC is a complex task that necessitates multidisciplinary care and patient-centered communication. This review provides clinicians and researchers with a comprehensive overview of the current challenges and future directions in IBC management. The goal is to guide treatment decisions and inform further research, ultimately improving patient outcomes and prognosis.
Post COVID-19 Syndromes -Some New Data on the Changes of Phosphocalcium Metabolism
Authors: Anghel Lucretia , Manole Corina , Nechita Aurel , Tatu Alin Laurențiu , Stefanescu Bogdan Ioan , Nechita Luiza Camelia , Busila Camelia , Pușica Zainea , Musat Carmina Liana , Baroiu Liliana
Published: July 2023

Phosphocalcium metabolism disorders have emerged as potential complications in individuals recovering from COVID-19. This abstract provides a concise summary of the current understanding of phosphocalcium metabolism disturbances post-COVID, their prevalence, clinical manifestations, and underlying mechanisms. The impact of COVID-19 on phosphorus, calcium, and parathyroid hormone levels is discussed, highlighting the importance of regular monitoring and appropriate management strategies. The abstract emphasizes the need for further research to enhance our understanding of these disorders and improve post-COVID patient care.
Properties and Applications of Gemini Surfactant 12-6-12: An Overview
Authors: Brycki Bogumił Eugene , Szulc Adrianna , Brycka Justyna , Kowalczyk Iwona
Published: July 2023

Surfactants are amphiphilic molecules and one of the most versatile products of the chemical industry. They can be absorbed at the air-water interface and can align themselves so that the hydrophobic part is in the air while the hydrophilic part is in water. This alignment lowers the surface or interfacial tension. Gemini surfactants are a modern variety of surfactants with unique properties and a very wide range of potential applications. Hexamethylene-1,6-bis(N-dodecyl-N,N-dimethylammonium bromide) is one such representative compound that is a better alternative to a single analogue. It shows excellent surface, antimicrobial, and anticorrosion properties. With a highly efficient synthetic method and a good ecological profile, it is a potential candidate for numerous applications, including biomedical applications.
CKM Matrix Parameters from an Algebra
Authors: SINGH TEJINDER PAL , PATEL ADITYA ANKUR
Published: July 2023

We report a theoretical derivation of the Cabibbo-Kobayashi-Maskawa (CKM) matrix parameters and the accompanying mixing angles. These results are arrived at from the exceptional Jordan algebra applied to quark states, and from expressing flavor eigenstates (i.e. left-chiral states) as superposition of mass eigenstates (i.e. the right-chiral states) weighted by square-root of mass. Flavor mixing for quarks is mediated by the square-root mass eigenstates, and the mass ratios used have been derived in earlier work from a left-right symmetric extension of the standard model. This permits a construction of the CKM matrix from first principles. There exist only four normed division algebras, they can be listed as follows - the real numbers $\mathbb{R}$, the complex numbers $\mathbb{C}$, the quaternions $\mathbb{H}$ and the octonions $\mathbb{O}$. The first three algebras are fairly well known; however, octonions as algebra are less studied. Recent research has pointed towards the importance of octonions in the study of high energy physics. Clifford algebras and the standard model are being studied closely. The main advantage of this approach is that the spinor representations of the fundamental fermions can be constructed easily here as the left ideals of the algebra. Also the action of various Spin Groups on these representations too can be studied easily. In this work, we build on some recent advances in the field and try to determine the CKM angles from an algebraic framework. We obtain the mixing angle values as $\theta_{12}=11.093^o, \theta_{13}=0.172^o, \theta_{23}=4.054^o$. In comparison, the corresponding experimentally measured values for these angles are $13.04^o \pm 0.05^o, 0.201^o \pm 0.011^o, 2.38^o \pm 0.06^o $. The agreement of theory with experiment is likely to improve when running of quark masses is taken into account.
Fuzzy Logic System for Classifying Multiple Sclerosis Patients: High, Medium or Low Responder to Interferon-Beta
Authors: Ponce de Leon-Sanchez Edgar , Mendiola-Santibañez Jorge , Dominguez-Ramirez Omar , Herrera-Navarro Ana , Vazquez-Cervantes Alberto , Jimenez-Hernandez Hugo , Senties-Madrid Horacio
Published: July 2023

Interferon-beta is one of the most widely prescribed disease-modifying therapies for multiple sclerosis patients. However, this treatment is only partially effective, and a significant proportion of patients do not respond to this drug. This paper proposes an alternative fuzzy logic system based on the opinion of a neurology expert to classify relapsing-remitting multiple sclerosis patients: high, medium, and low responder to interferon-beta. Also, a pipeline prediction model trained with biomarkers associated to interferon-beta response is proposed for predicting whether patients are potential candidates to be treated with this drug, in order to avoid ineffective therapies. The classification results shows that the fuzzy system presents a 100% efficiency compared with an unsupervised hierarchical clustering method (52%). So, the performance of the prediction model is evaluated, and a 0.8 testing accuracy is achieved. Hence, a pipeline model including data standardization, data compression, and a learning algorithm, can be a useful tool for getting reliable predictions about the response to interferon-beta.
A Molecular Orchestration of Plant Translation under Abiotic Stress
Authors: Suhorukova Aleksandra V. , Sobolev Denis S. , Milovskaya Irina G. , Fadeev Vitaliy S. , Goldenkova-Pavlova Irina V. , Tyurin Alexander A.
Published: July 2023

The intricacies of translational strategies make this stage of the implementation of genetic information one of the most difficult to understand and, at the same time, perhaps the most interesting. It also becomes clear that all this variety of strategies is not just a consequence of a long evolutionary history but is of paramount importance for fine-tuning gene expression and metabolic modulation. This is especially true for those organisms that demonstrate predominantly biochemical and physiological reactions with a lack of behavioural ones. Plants are just such a group of organisms. Overcoming unfavourable environmental conditions occupies a key place in plant physiology. This is especially true with the changing conditions of global warming and the irretrievable loss or depletion of natural ecosystems. Conceptually, the response of plants to abiotic stress is a set of complex and intricate strategies. This is dictated both by a variety of abiotic factors that provoke stressful conditions and by a variety of molecular genetic mechanisms that make it possible to fine-tune the metabolic pathways through which the plant organism overcomes non-standard and non-optimal conditions. In the presented review, we tried to focus on the state-of-the-art in the field of translational regulation in plants under abiotic stress conditions. Various regulatory elements and patterns are considered in relative chronological order. We also considered it necessary to pay attention to key high-performance methods for studying the dynamics of genetic information at the stage of translation.
A Dynamic Network Loading Model for Hub Station Pedestrian Flow Collection and Distribution
Authors: Zheng Weihao , Mou Rui-fang
Published: July 2023

A macro network loading Model for multi-flow lines, time-varying and pedestrian congestion is proposed. The station hub is abstracted as a network of different types of nodes, and the flow of passengers at each node is calculated in real time for the purpose of simulating the hub's collection and distribution process. For correct transmission of passenger flow on heterogeneous networks, three types of indexes are proposed to distinguish the nodes, and then match the corresponding fundamental diagrams. This paper divides the update process of the dynamic network loading model into multiple processes by flow lines, and improves computational speed of DNL model. The proposed model is applied to the simulation of passenger flow collection and distribution in an actual hub station with multi-flow lines. The analysis results illustrate that the model can accurately reflect the realistic congestion facilities and explain the formation process of high-density areas. A rolling passenger flow control model based on optimal control theory is proposed. The effectiveness of the control model is verified based on simulation data.
Theoretical Study of Structure and Photophysics of Homologous Series of Bis(arylydene)cycloalkanones
Authors: Starostin Roman O. , Freidzon Alexandra Ya. , Gromov Sergey P.
Published: July 2023

Photophysical properties of a series of bis(arylydene)cycloalkanone dyes with various donor substituentns are studied by quantum chemistry. Their capacity for luminescence and nonradiative relaxation through trans-cis isomerization is related to their structure, in particular, to the donor capacity of the substituents and the degree of conjugation due to the central cycloalkanone moiety. It is shown that cyclohexanone central moiety introduces distortions and disrupts the conjugation, thus leading to a nonmonotonic change in their properties. The increasing donor capacity of the substituents causes increase in the HOMO energy (raise of the oxidation potential) and decrease in the HOMO-LUMO gap, which results in the red shift of the absorption spectra. The ability of the excited dye to relax through fluorescence or through trans-cis isomerization is governed by the height of the barrier between the Franck–Condon and S1-S0 conical intersection regions on the potential energy surface of the lowest π-π* excited state. This barrier also correlates with the donor capacity of the substituents and the degree of conjugation between the central and donor moieties. The calculated fluorescence and trans-cis isomerization rates are in good agreement with the observed fluorescence quantum yields.
Simulating Heavy Rainfall Associated with Tropical Cyclones and Atmospheric Disturbances in Thailand using the Coupled WRF-ROMS Model - Sensitivity Analysis of Microphysics and Cumulus Parameterization Schemes
Authors: Torsri Kritanai , Faikrua Apiwat , Peangta Pattarapoom , Sawangwattanaphaibun Rati , Akaranee Jakrapop , Sarinnapakorn Kanoksri
Published: July 2023

This study aims to identify the optimal combination of microphysics (MP) and cumulus (CU) parameterization schemes for accurately simulating heavy to violet rainfall events associated with Tropical Cyclones (TCs) and atmospheric disturbances in Thailand using the coupled Weather Research and Forecasting (WRF) and Regional Oceanic Model (ROMS), hereafter referred to as WRF-ROMS. Three CU schemes, namely Betts–Miller–Janjic (BMJ), Grell 3D Ensemble (G3), and Kain–Fritsch (KF), along with three MP schemes, namely Eta (ETA), Purdue Lin (LIN), and WRF Single-moment 3-class (WSM3), are selected for the sensitivity analysis. Seven instances of heavy to violent rainfall in Thailand, occurring during summer season of 2020 and associated with tropical storms and atmospheric disturbances, are simulated using all possible combinations of the chosen physics schemes. The simulated rain intensities are compared against observations from the National Hydroinformatics Data Center. Performance was assessed using the Probability of Detection (POD), False Alarm Ratio (FAR), and Critical Success Index (CSI) metrics. The models showed proficiency in predicting light to moderate rainfall, with certain combinations performing better in specific rainfall categories. However, forecasting heavy and violent rainfall proved challenging for all models and lead-time forecasts. Specific combinations, particularly those incorporating the KF scheme, demonstrated superior prediction of heavy to violent rainfall. The FAR values increased with lead-time and rain intensity, and the KF scheme combinations showed improved predictions of intense rainfall with lower FAR values. The CSI values indicated comparable performance between the control model and combination models across light to heavy rain categories, with the KF scheme showing better predictions for longer lead-times. However, accurately predicting intense rainfall remained limited. These findings highlight the need for further improvements, including refining model parameters and exploring advanced techniques to enhance accuracy and skill, particularly for longer-term forecasts. Sub-seasonal to seasonal prediction should be considered to extend forecast capabilities.
Variability of Sentinel Lymph Node Location in Patients with Trunk Melanoma
Authors: Bobirca Florin , Leventer Mihaela , Georgescu Dragos Eugen , Dumitrescu Dan Andrei , Alexandru Cristina , Serban Dragos , Valeanu Liana , Pătrașcu Traian , Bobircă Anca
Published: July 2023

(1) Background: Melanoma is the most aggressive tumor located at the skin level and the man-agement of this pathology requires a correct staging as well as a modern oncological treatment, adapted to each patient. The main objective of the study is to determine the variability of lymphatic drainage in the case of melanomas located on the trunk; (2) Methods: This retrospective study in-cluded 62 cases of melanoma located on the trunk operated between July 2019 and March 2023 in which SLNB was performed and a total of 84 lymph node were excised; (3) Results: Patients had an average age of 54.5 years old, while melanomas had a mean Breslow index of 2.3 mm. The distri-bution of trunk melanomas was: upper trunk 54 cases, lower trunk 30 cases (64.3 % vs. 35.7%). The type of anesthesia chosen was general anesthesia in 53 cases, respectively spinal anesthesia in 9 cases (85.5% vs. 14.5%, p<0.001). The number of sentinel lymph nodes was 54 for melanomas lo-cated on the upper trunk, 8 cervical and 46 axillary, respectively 30 sentinel lymph nodes in cases of melanomas of the lower trunk, 16 at the axillary level and 14 at the inguinal level; (4) Conclusions: Lymph node involvement in melanoma represents an important prognostic factor and the different lymphatic drainage pathways in relation to the location of the primary tumor represents an im-portant objective in the management of this pathology.
Discover Your Passion with A College Major Exploration Web App
Authors: Uriawan Wisnu , Fatur Rozak Muhamad Gani , Suhendar Hilman , Nurtamami Ighna , Nurfiani Indri , Al'Afaf Banie
Published: July 2023

Choosing a college major is a crucial issue for twelfth-grade students. Many students feel confused and influenced by their surroundings when making this decision. This can have negative consequences if it does not align with the students interests and talents. This research proposes a web application as a solution, providing introductory information for each major. We employed a design and developement approach to create an application that assists prospective students in identifying majors based on their interests. The primary objective is to alleviate students discomfort during their studies, which often leads to decreased performance. With this application, students can avoid selecting majors solely due to peer pressure or parental coercion.
Simulation Study of the Lunar Spectral Irradiances and the Earth-Based Moon Observation Geometry
Authors: Lian Yi , Renyang Qianqian , Tang Tianqi , Zhang Hu , Ping Jinsong , Meng Zhiguo , Li Wenxiao , Gao Huichun
Published: July 2023

As a radiant light source within the dynamic range of most spacecraft payloads, the moon pro-vides an excellent reference for on-orbit radiometric calibration. This research hinges on the pre-cise simulation of lunar spectral irradiances and the Earth-based Moon observation geometry. The paper leverages the Hapke model to simulate the temporal changes in lunar spectral irradi-ances, utilizing datasets obtained from Lunar Reconnaissance Orbiter Camera (LROC). The re-search also details the transformation process from the lunar geographic coordinate system to the instantaneous projection coordinate system, thereby delineating the necessary observational geometry. The insights offered by this study have the potential to enhance future in-orbit space-craft calibration procedures, thereby boosting the fidelity of data gathered from satellite obser-vations.
The deficits of insulin signal in Alzheimer’s disease and the mechanisms of vanadium compounds in curing AD
Authors: Yao Jinyi , He Zhijun , You Guanying , Liu Qiong , Li Nan
Published: July 2023

Vanadium is a well-known essential trace element, which usually exists in oxidation states in form of vanadate cation intracellularly. The pharmacological study of vanadium begins at the discovery of its unexpected inhibitory effect on ATPase. Thereafter, the protective effects on cells and the abilities in glucose metabolism regulation were observed from vanadium compound, leading to the application of vanadium compounds in clinical trials for curing diabetes. Alzheimer’s dis-ease (AD) is the most common dementia disease in elderly people. However, there is still no efficient agents for treating AD safely to date. This is mainly because of the complexity of the pathology, which are characterized by the senile plaques composed by amyloid-beta (Aβ) protein in the parenchyma of brain and the neurofibrillary tangles (NFTs) derived from hyperphosphorylated tau protein in neurocyte, along with mitochondrial damage, and eventually the central nervous system (CNS) atrophy. AD was also illustrated as type-3 diabetes, because of the observations of insulin deficiency and the high level of glucose in cerebrospinal fluid (CSF), as well as the im-paired insulin signaling in brain. In this review, we summarized the advance of applicating vanadium compound on AD treatment in experimental research and pointed out the limitation of the current study on using vanadium compounds in AD treatment. We hope it will help the future study in this field.
A Review on Advanced Processes of Bio Hydrogen Generation from Lignocellulosic Biomass with Special Emphasis on Thermochemical Conversion
Authors: Sharma Rajat Kumar , Nazari Mohmmad Ali , Haydary Juma , Singh Triveni Prasad , Mandal Sandip
Published: July 2023

The utilization of lignocellulosic biomass as an alternative energy source presents a promising opportunity to achieve a future energy system that is clean and free from CO2 emissions. To realize this potential, it is crucial to develop effective techniques for converting biomass and organic solid waste into secondary energy sources. Among the available options, hydrogen production stands out due to its numerous advantages, including its cleanliness, versatility in conversion and utilization technologies, high energy efficiency, and dense energy content per unit weight. This article offers a comprehensive overview of different conversion pathways and important technologies for generating hydrogen from biomass and organic solid waste. It specifically focuses on the thermochemical conversion process, which shows promise as an economically viable approach. While certain thermochemical conversion processes are still in the developmental phase, utilizing organic biomass for hydrogen production is widely recommended due to its ability to yield higher amounts of end products and its compatibility with existing facilities. However, it should be noted that this method necessitates a substantial amount of energy due to its endothermic nature. The article also explores alternative hydrogen conversion technologies and their potential for utilizing organic biomass as a feedstock, while addressing the challenges and limitations associated with these methods.