bluuebunny/crossref_metadata_2025 huggingface dataset:
Integrated analysis of phase 1a and 1b randomized controlled trials; Treg-targeted cancer immunotherapy with the humanized anti-CCR4 antibody, KW-0761, for advanced solid tumors
Authors: Fujikawa Kaoru , Saito Takuro , Kurose Koji , Kojima Takashi , Funakoshi Takeru , Sato Eiichi , Kakimi Kazuhiro , Iida Shinsuke , Doki Yuichiro , Oka Mikio , Ueda Ryuzo , Wada Hisashi
Published: September 2023

Introduction

Regulatory T cells (Tregs) have attracted attention as a novel therapeutic target to augment the clinical efficacy of immunotherapy. We conducted phase Ia and Ib trials to examine the safety and efficacy of the anti-CCR4 antibody, KW-0761 (mogamulizumab), which may eliminate effector Tregs (eTregs). We herein overviewed the results of these trials, presented cases with a durable clinical response, and investigated factors associated with the clinical effects of KW-0761.

Methods

Forty-nine patients with CCR4-negative solid cancers were enrolled in the phase Ia and Ib trials on KW-0761. An integral analysis of safety, clinical responses, prognosis, blood laboratory data, and cancer testis antigen-specific immune responses was performed.

Results

Grade 3–4 treatment-related adverse events were reported in 21 (42.9%) out of 49 patients, all of which were manageable. A partial response and stable disease were observed in 1 and 9 patients, respectively. A durable clinical response was noted in 2 esophageal and 2 lung cancer patients. eTreg depletion in peripheral blood was confirmed in most patients, and eTreg depletion was sustained during the KW-0761 treatment. High lymphocyte levels at baseline and 2 weeks after the initiation of KW-0761 were associated with a favorable clinical outcome.

Conclusions

A durable clinical response was noted in some patients, and high lymphocyte levels before treatment initiation may be a biomarker for the efficacy of KW-0761. The synergistic effect of KW-0761 for depleting Tregs and other immunotherapies is expected in the future.
Aproximación al pensamiento de Cristina Campo
Authors: López Fajardo Fernando
Published: September 2023

Casi en los márgenes de la literatura contemporánea italiana se encuentra Vittoria Guerrini, más conocida como Cristina Campo. Esta intelectual, a la cual nunca le gustó lo que escribió y le hubiera gustado escribir menos, paradójicamente, ha alcanzado renombre entre las escritoras italianas del siglo xx. Su obra poética, dotada de perfección y belleza, no puede entenderse sin la base filosófica que la sustenta, por lo que este estudio trazará la relación entre la poesía y el pensamiento campianos.
La zia marchesa di Simonetta Agnello Hornby: un caso di riabilitazione letteraria
Authors: Malandrin Federico
Published: September 2023

Attraverso La zia marchesa Simonetta Agnello Horby riesce nel proposito di riscattare la reputazione di una sua lontana parente rispetto all’immagine svilente che di lei viene data da Pirandello nella novella Tutt’e tre. Il confronto sistematico tra il romanzo e il racconto pirandelliano permette però di istituire un più ampio e articolato ragionamento sulla condizione femminile nella Sicilia tardo ottocentesca e sulle problematiche di carattere storico e politico che si presentano nell’isola nei decenni successivi all’Unificazione italiana.
Una Sardegna magica: tradizione e innovazione nei racconti fantastici di Grazia Deledda
Authors: Manfrecola Sonia
Published: September 2023

L’articolo è volto ad analizzare la figura di Deledda come autrice di letteratura fantastica, ruolo che non le fu mai riconosciuto dai compilatori delle prime antologie italiane sul fantastico, nonostante la scrittrice avesse dato vita a racconti originali, in cui il magico si univa indissolubilmente al folclore e all’essenza sarda. Infine, attraverso un’analisi contrastiva, si prenderanno in esame elementi della sua produzione novellistica che anticiparono alcuni caratteri del realismo magico latinoamericano.
As Marcas Das Marcas: Uma Revisão Conceitual Necessária....
Authors: Rückert Jungkenn Glória , Andrade Scroferneker Cleusa Maria
Published: September 2023

Alicerçados na comunicação e na comunicação organizacional, nos propomos a refletir sobre as possíveis conceituações e compressões das marcas a partir de trilhas teórico-reflexivas (GIL, 2008; STUMPF, 2006). Ao longo do percurso, destacamos aproximações e afastamentos entre as perspectivas revisadas, por meio de representações visuais em linhas do tempo construídas entre 2002 e 2021 que evidenciam o que ‘marcou’ as marcas nas abordagens teóricas.
Narratív és nem narratív filmes szerkezet megértésének
összehasonlítása befogadói szövegekben
Authors: Papp-Zipernovszky Orsolya , Volosin Márta , Deák-Kovács Tímea , Kovács András Bálint
Published: September 2023

Empirikus vizsgálatsorozatunkban azt a kérdést helyeztük a fókuszba,
hogy milyen – alacsony és magas szintű - mentális műveletek zajlanak egy
narratív és egy nem narratív film befogadásakor a nézőben. 2019-ben EEG-vel
és szóasszociációs módszerrel végzett vizsgálatunk következtetése, hogy a
narratív film esetében nagyobb mentális erőfeszítést tesz a néző a térbeli
orientáció és a térbeli figyelem terén, míg a nem narratív film befogadása
nagyobb memóriamunkát igényel, és folyamatos erőfeszítést a szereplők
megértésében. Ezek alapján feltételezhető, hogy a szereplős, de nem
koherens filmek esetében a nézők hasonló megértési stratégiával
próbálkoznak, mint a koherens film esetében. Ezt a feltételezést teszteljük
jelen vizsgálat során, ahol ugyanannak a filmnek eredeti és átvágott
változatát mutattuk 42 vizsgálati személynek (20 férfi és 22 nő,
átlagéletkoruk 32,7 év (SD=9,05)). A filmek érthetőségének/nem
érthetőségének validálása során az online következtetések, a Narratív
Bevonódás Skála és a cselekmény retrospektív összefoglaló szövegeinek
elemzése által nyert eredmények újabb hipotéziseket vetettek föl. A
koherens változat esetében sokkal gyakoribbak voltak a tér-idő, a szereplők
érzései, valamint a történés és a cél kategóriái, míg a nem koherens
változatot inkább az események nagy szerkezetbe való beillesztésével és a
szereplők azonosításának kategóriáival próbálják magyarázni.
Analysis of the Impact of Introducing a Safety and Health Management System in Public Organization on Accident Prevention and Management
Authors:   Crisis and Emergency Management: Theory and Praxis, Lee Moon Sun , Yoo Byung Tae
Published: September 2023

In December 2018, a series of accidents occurred in public organizations, including a rupture in an old heat transport pipe near Baekseok Station in Goyang-si, a derailment of the Gangneung Line KTX train, and a young worker trapped in the Taean Thermal Power Plant. Consequently, the government has issued guidelines outlining comprehensive measures to enhance safety in public organizations and safety management. However, there is insufficient research on the results and effects of these measures. This study analyzed the impact of implementing the safety and health management system and designating safety management priority organizations on the safety management grades of 99 public organizations included in the safety management rating system in 2021. Based on the results of this study, it can contribute to preventing safety accidents in the public sector. Furthermore, it emphasizes that this can be achieved by improving the safety capabilities of central administrative agencies, local governments, and local public enterprises that share similar work characteristics with public organizations.
Estimation of Characteristics of Wildfire Surface Fuel for Pinus Rigida Stands in Chungnam Province
Authors:   Crisis and Emergency Management: Theory and Praxis, Kim Sung Yong , Lee Ye Eun , Kwon Chun Geun , Lee Young Jin , Jang Mi Na
Published: September 2023

This study purpose to analyze the characteristics of surface fuel load and estimate potential crown fire transition hazards in Pinus Rigida stands. Surface fuels were collected from 96 samples in Pinus Rigida stands. A wildfire spread equation presented in foreign countries was applied to analyze the potential crown fire transition hazard in Korea. The results of this study showed that the percentage of dead leaves in the surface fuel was over 70%, followed by snag, herb, shrubs. As the age increased the amount of fuel for shrubs and herbs decreased, while the amount of fuel for dead leaves and snag increased. The critical values to assessment of surface fire intensity was 1223.95 kW/m in the Ⅱ age class, 2249.24 kW/m in the Ⅲ age calss, 2954.95 kW/m in the Ⅳ age class, 3125.29 kW/m in the Ⅴ age class. the age increased the higher the flame intensity required for crown fire transition. The critical values to assessment of flame length was 2.033m in the Ⅱ age class and 3.275m in the Ⅲ age class. The results if this study were used to develop a wildfire fuel model for coniferous species in South Korea.
Research on Effective Establishment of Disaster Safety Knowledge Sharing System
Authors:   Crisis and Emergency Management: Theory and Praxis, Jin Hye Rin , Lee Chang Kil
Published: September 2023

Recently, data-based administration is being activated to strengthen the ability to predict and respond to disasters. Accordingly, the importance of efficient decision-making using disaster safety information and data and preparation of prediction and response plans is emerging. Therefore, this study analyzed the current state of the disaster safety management information system for practical collection and sharing of distributed disaster safety data and information and application of a user-centered sharing platform. Problems were derived and the development direction of the disaster safety data sharing platform currently under construction was proposed. As a result of the analysis, many of the problems in the disaster safety knowledge information sharing system that have been continuously pointed out in the past have not been improved. Problems of the disaster safety knowledge sharing platform include the lack of data provider institutions, limited disaster type classification, lack of real-time disaster situation information, lack of visualization and analysis functions, and lack of network communities among users. As an improvement plan, a data connection plan and a plan to provide information for each stage of disaster management were presented. In addition, diversification of data format and strengthening of networking among users were suggested.
RAW Radicals
Authors: Hamblin Sarah
Published: September 2023

This chapter argues that while RAW did spearhead an aesthetic revolution, this revolution did not come at the expense of political radicalism. Rather, RAW's stylistic experiments link formal innovation with radical cultural critique. In their role as editors, the chapter chronicles how Spiegelman and Françoise Mouly pursued anticapitalist and anti-Reaganite positions through the artists they published and the thematic focus of each issue. At the same time, radical politics informs both the form and content of Spiegelman's own contributions to RAW, as well as the design of the magazine itself. The chapter then recounts that as editor and contributor, then, Spiegelman privileges certain political aesthetics to critique Reagan-era neoliberalism and to promote a critical engagement with image culture that works to reaffirm comics as a site of resistance. In examining RAW's place within the radical comics tradition, the chapter documents a political sensibility that has been overlooked in discussions of RAW and of Spiegelman's work more generally to argue that RAW's avant-garde aesthetic is not in opposition to its radical politics, but at its center.
Of Mice and Masks
Authors: Futerman Liza
Published: September 2023

This chapter engages with the photographs integrated in Art Spiegelman's Maus to argue that their incorporation in the graphic narrative probes the intrinsic documentary quality of Holocaust photography and questions our reliance on “photography's spectral power.” Despite photography's much-touted facticity, the chapter insists, in representing an event like the Holocaust, comics are better placed to convey the inaccessibility of the past. The chapter then focuses on the questions raised by the actual and simulated photographs in the graphic memoir. Needless to say, the photographs in Maus have attracted an overwhelming amount of scholarly attention. And yet, as the chapter elucidates, observing them through the prism of another graphic device—the mask—reveals a novel vantage point that might otherwise have been obscured. Ultimately, the chapter contends that Spiegelman on the one hand challenges the value of photography as a direct access point to the past and on the other hand elevates the documentary quality of comics. In doing so, the chapter invites us to approach comics with the understanding that it can provide historical evidence where other forms of representation fall short.
Migrant (Un)Homeliness
Authors: Falola Toyin
Published: September 2023

African postcolonial writers, such as A. B. Asssensoh and Cherno Njie, have creatively interpreted and highlighted the concepts of home and identity by describing the forces that affect our individual, continental, and globalized existence and realities in their memoirs. These interpretations can be evaluated to determine their effectiveness in confronting and understanding African life and culture. African memoir writings, Afropolitanism, and “glocalisation” have been appraised from the broad-spectrum perspective of universalism, Pan-Africanism, and cosmopolitanism. This chapter surveys biographical writings from the viewpoint of Africans in the diaspora, discussing how these works have presented African portraiture in line with cultural realism in the global sphere.
“Was I going to heed the call of my acid visions and cast my lot with the counterculture?”
Authors: Utell Janine
Published: September 2023

Beginning with Howard Cruse’s presence at the Stonewall uprising in 1969, this chapter tells of Cruse’s attempts to start a career as a cartoonist, his use of hallucinogens as part of his artistic process and personal development, and his openly acknowledging being gay. The chapter focuses on Cruse’s work in television, and on publishing cartoons in underground alternative papers in Birmingham. It concludes with the creation of Barefootz.
“I’d like for people—if they looked at the totality of my work—to feel they have come to know me as a person”
Authors: Utell Janine
Published: September 2023

This chapter focuses on the later years of Howard Cruse, including his death in 2019. The chapter tells of Cruse’s marriage to Ed Sedarbaum in the context of marriage equality, after their move to the Berkshires. The chapter examines Cruse’s feelings about his legacy.
Baptism
Authors: Fenimore Wanda Little
Published: September 2023

Chapter 1 begins with the blinding of Army Sgt. Isaac Woodard, Jr. on February 12, 1946. After months of the NAACP pressuring the federal government, the Department of Justice indicted Lynwood Shull, the police chief who attacked Woodard. Judge J. Waties Waring presided over Shull’s trial on November 5, 1946, in Columbia. Socially ostracized in Charleston, Judge Waring’s second wife, the former Elizabeth Hoffman, accompanied the judge to the state’s capital, sat in the courtroom, heard Woodard’s testimony, and saw his damaged eyes. The trial profoundly affected the Warings and precipitated their quest to learn more about race relations in the South. They began with W. J. Cash’s The Mind of the South and Gunnar Myrdal’s An American Dilemma. Based on the Jim Crow justice that the Warings witnessed at the Shull trial and their readings, they came to believe that racial violence was a manifestation of segregation.
Predator Assemblages
Authors: Lechuga Michael
Published: September 2023

Chapter Two describes the alien-making processes used to create and grow the Predator film franchise for more than three decades. Many surveillance technologies are employed to manufacture the Predator alien in the cinematic imaginations of U.S. filmgoers. This chapter describes how the production of the Predator alien relies on the visualization of the alien’s cloaking ability and its super-perception—infra-red and night-vision. As these technologies have quickly evolved over the last three decades in the films, they have also been more actively mobilized to subject migrants as aliens along the México/U.S. border. The U.S. Border Patrol relies on Predator technologies to aid in the militarization of the borderland, driving migrants through certain corridors with the hopes of apprehending most of them. The chapter ends with a discussion of legal and juridical apparatuses that organize these technologies to promote a constitutive citizenship paradigm at the heart of U.S. immigration policy.
Conclusion
Authors: Lechuga Michael
Published: September 2023

The closing chapter of Visions of Invasion confronts readers with the grim reality of how alien-making has primed the U.S. political landscape for a resurgence of a white settler nationalism. The conclusion describes a common trope from alien invasion—the destruction of the U.S. Capitol—and what it means in terms of settler consciousness. Scenes from the film Mars Attacks! frame the conversation about alien-making and the ongoing settler violences in the U.S., including the January 6, 2021 attack on the U.S. Capitol and the ongoing aggression toward migrant communities. These examples demonstrate how the settler alien making project has shifted focus from decades of dehumanizing foreigners to now making anyone who opposes white nationalist policies into an alien invader. The book ends by calling on co-conspirators in the anti-colonial project to narrate the end of settler colonialism—rejecting settler subjectivities, settler claims to sovereignty, and the circulation of settler narratives.
Chirping’Bout My Generation
Authors: Abate Michelle Ann
Published: September 2023

Chapter Six spotlights Snoopy’s comedic sidekick and feathered friend, Woodstock. More specifically, it ponders his most stubbornly elusive feature: his name. While previous critics have concluded that there is no clear, direct, or obvious reason that Schulz chose to name his little yellow bird after the historic musical festival that took place in upstate New York in August 1969, this chapter makes a case that the moniker is highly resonant. By naming the character after the well-known event, Schulz invites his readers to see him as a metaphor or even metonym for it. At the same time, and perhaps even more importantly, the cartoonist is also encouraging them to see Woodstock as an embodiment of the era’s young people, the Woodstock Generation. Reexamining Schulz’s Woodstock through this lens changes our perception of him along with his role in the comic. The little bird is Snoopy’s best friend and comedic sidekick, but he is also a conduit for socio-political issues. When Peanuts debuted on October 2, 1950, the comic strip offered a pointed commentary on U.S. children and childhood. Twenty years later, in June 1970 when Schulz names his little bird Woodstock, he revisits this interest for the new generation of young people. With the decision to name a character Woodstock, the comic strip takes up questions of youth and youth culture once again.
Beyond Interesting
Authors: Brinkman Eric
Published: September 2023

Drawing on affect theorists such Deleuze, Laura Podalsky and Brian Massumi, this chapter focus on affect as embodied pre-socio-linguistic responses; that is, affect is a description of bodily sensation before being constrained by predetermined emotional categories. What this accomplishes in the context of Bouchet’s performances in giallo films is the suggestion to the audience of a complex character whose motives are often obscured and perhaps even unknowable, which maps on to the giallo convention of a psycho-sexual mysterious killer very effectively.
“This is no Longer a Metaphor But a Demonstration”
Authors: Mee Sharon Jane
Published: September 2023

This chapter examines Hélène Cattet and Bruno Forzani’s neo-giallo film L’étrange couleur des larmes de ton corps/The Strange Color of Your Body’s Tears (2013). Drawing on Gilles Deleuze’s theory of color—and “red [as] the unique tone of blood”—in Cinema 1: The Movement-Image and Cinema 2: The Time-Image, this chapter seeks to understand the architectural aesthetics of the neo-giallo film (Deleuze 1989, 182–183). The Strange Color of Your Body’s Tears demonstrates an architectural aesthetics through the grandiose architectural tableaus and passageways that stage the scenes of murder, the psychological “architecture” of the characters’ traumatized minds, and the interstices between split screens as the spaces into which color bleeds for the spectator.
Notes sur la portée politique du paysage
Authors: De Visscher Jean-Philippe
Published: September 2023

Le paysage, comme objet de pensée théorique et comme horizon des transformations matérielles, mobilise depuis quelques années de nombreuses disciplines de recherche. Il s’est émancipé de ses attaches originaires qui l’assimilaient à une esthétique du visible, et plus largement, à une représentation de la nature humanisée. Il est à peu près entendu aujourd’hui que la notion de paysage excède à la fois, sans toutefois les exclure, la visibilité des territoires et les formes apparentes de la nature. Les paysages sont noués au plus intime des dispositifs culturels où nos sociétés se conduisent, de telle sorte qu’ils en paraissent à la fois causes et effets : nous « produisons » les paysages ­(nous fabriquons leur artificialité qui façonne jusqu’à nos sentiments de la nature), et aussi bien les paysages réels pèsent ou facilitent : ils participent à l’ensemble des structures sociétales, à ce titre ils « agissent » sur nos objets mentaux, nos images du monde, nos comportements individuels ou collectifs, et leur permettent de s’articuler réciproquement.Si les paysages ne sont pas les simples projections des activités humaines sur les milieux ambiants, mais engagent de facto la réalité même des déploiements sociaux, il convient d’admettre qu’ils ne sont pas disposés aléatoirement, mais au contraire qu’ils s’ordonnent et qu’ils ordonnent au sein des dispositifs culturels auxquels nous participons : ils sont architecturés et leurs architectures réclament d’être pensées théoriquement.Le texte de Jean-Philippe de Visscher que nous publions ce mois de juin 2007 répond significativement à une telle exigence. Il porte le titre "Note sur la portée politique de la notion de paysage"; en voici un extrait : « ...la portée du paysage dépasse, me semble-t-il, la simple constitution d’une "belle composition″ offerte à la contemplation. Le mot paysage se dégage de sa référence usuelle à la peinture de paysage et de sa réduction à un objet esthétique : reprendre l’écriture d’un paysage – et, par là même, condamner sa possible fin – est un acte profondément politique. En (ré-)instituant son caractère impossédable, s’instaure simultanément sa dimension publique.»
Limites, passages et transformations en jeu dans une architecture des milieux
Authors: Younès Chris
Published: September 2023

"Limites, passages et transformations en jeu dans une architecture des milieux" synthétise les préoccupations et les directions de recherche de son auteur. Nous connaissons le souci de Chris Younès de déployer une pensée philosophique qui s'interdise de surplomber avec superbe la conduite du projet d'architecture, mais qui, au contraire, tente de s'y nouer en figures d'entrelacs. A cet égard, le texte publié dans ce numéro Des pages du laa possède une valeur programmatique.

 

"La manière de tracer des limites et d’opérer des passages par transferts, incursions, interférences notamment, rend compte du mode d’expression propre à l’architecture et de sa façon d’agencer le stable et l’instable, le délimité et l’illimité, la mesure et l’incommensurable, la continuité et la discontinuité. Entre Terre et Monde, l’art de les mettre en œuvre par le projet architectural, urbain et paysager est une des problématiques d’une architecture des milieux. Ce qui requiert d’envisager aussi bien les limites et passages entre disciplines qu’entre nature et artefact."

 

"Limites, passages et transformations en jeu dans une architecture des milieux" a fait l'objet d'une première publication dans le Philotope n°6, en 2007. Le Philotope est la lettre du réseau PHILAU (Réseau scientifique thématique Philosophie Architecture Urbain).
Glose I
Authors: Marchal Pierre
Published: September 2023

Une des questions qui mobilise les efforts du laa se voit à nouveau mise en exergue : quid des rapports langage/langue/architecture ? L'approche structurale (post Lacan) et l'approche historiale (post Heidegger) sont conjointement sollicitées en cette contribution de Pierre Marchal.Pierre Marchal s'interroge quant aux effets et fécondités potentiels de telles discussions au coeur des pratiques des architectes qui "produisent". Nous tenons, au sein du laa, qu'il n'y a pas de pratique de l'architecture qui puisse s'extraire de l'interrogation perpétuelle de ce qu'elle dispose anthropiquement, culturellement, politiquement.Voici un extrait de la contribution de Pierre Marchal : "Si nous acceptons de nous démarquer quelque peu de l’imaginaire que nous venons de convoquer et d’accéder à une approche plus abstraite, plus symbolique, l’architecture pourrait bien nous apparaître comme l’opération, la fonction qui aménage un espace pour le principe. Cela n’est pas sans rapport avec le divin, le sacré, lieu qui fait fondement et commencement et à partir duquel peut venir s’inscrire la discontinuité donnant naissance à la continuité historique. Il ne serait d’ailleurs pas hors propos que les étudiants en architecture aient quelques notions de l’histoire des religions. D’ailleurs, les débuts de l’architecture monumentale ne concernent-ils pas les temples (habitat divins) et les tombes royales."
Ce que Lacan n'a pas dit (...)
Authors: Montalbetti Mario
Published: September 2023

"Ce que Lacan n'a pas dit (sur l'architecture) est aussi organisé comme ce qu'il a dit (sur le langage)." Tel est le titre de l'article que nous propose Mario Montalbetti. Après avoir déplié et commenté la phrase de Jacques Lacan : "Le sens indique la direction vers laquelle il échoue", Mario Montalbetti mobilise les articulations qu'il a engrangées à l'endroit du mur - élément d'architecture."Pourquoi une psychanalyse se termine-t-elle ?, pourquoi une phrase se termine-t-elle ?,… pourquoi un mur arrête-t-il de se déployer ? Les questions paraissent banales si nous demeurons dans les réponses matérielles : l’analyse se conclut parce que le patient s’ennuie, ou parce qu’il n’a plus d’argent pour payer les séances, ou qu’il tombe malade,… ; la phrase se termine parce que le sujet parlant est fatigué, ou parce qu’il veut changer de place, ou parce qu’il croit avoir dit tout ce qu’il souhaite dire,… ; le mur arrête de s’étendre aux limites du terrain, pour cause d’ajustement du budget des travaux, parce que l’architecte a changé d’avis, ou bien son client,… Mais, au-delà de ces raisons contingentes, pourquoi ces processus s’arrêtent-ils ? Il n’y a pas de raison théorique fiable que l’on puisse revendiquer au-delà de certains compromis avec les faits. (...) Et le compromis de l’architecture serait peut-être : le mur arrête de s’étendre parce que l’on souhaite habiter. "
Folding (Aspelare, Belgium)
Authors: Ank Stijn
Published: September 2023

Voici d FOLDING, une architecture proposée par Stijn Ank, construite dans la localité de Aspelare, en Belgique.

Nous considérons que cette proposition rompt avec les "variations sur un même thème", manières actuelles de "proposer" à l'abri d'un "audimat", où l'assimilation sociale vaut comme vecteur d'invention !!!!

Cette proposition de Stijn Ank ne rejoint pas le cortège interminable des variations sur les thèmes de :

la transparence du monde et de son habitation

la victoire sur le poids de la matière (réputée constituer une entrave à la liberté des désirs)

Seul un examen distrait s'en laisserait convaincre. Il nous semble, au contraire, que cette proposition rejoint les questions :

au départ de quelles conditions minimales est-il possible d'habiter un "site" ?

de quelles natures sont les articulations entre un "lieu" et un "site" où habiter?

qu'est-ce qu'habiter un "site", dès lors que la clôture du privé est renvoyée à sa misère bourgeoise ?

Ces questions devraient compter parmi celles qui fabriquent notre temps !
L’architecture théorique|anthropologique
Authors: Stillemans Jean
Published: September 2023

Il faut dire le caractère singulier de ce texte. Eu égard d’abord aux travaux que le laa accueille habituellement sur ses pages, son enjeu n’est pas d’éclairer sous un jour théorique quelques faits architecturaux, ni de fixer, à une distance plus grande encore, les objets et les tâches d’une théorie de l’architecture. Le texte « architecture théorique | anthropologique » s’inscrit plutôt dans la tradition des manifestes architecturaux. C’est dire qu’il appartient à un genre prescriptif dont la vocation discursive est de méditer voire d’orienter le destin de la discipline architecturale. Mais, sa singularité au sein même du genre prescriptif tient au fait qu’il propose un destin architectural qui s’appuie sur la théorie, et pourtant renverse la perspective propre aux théories d’architecture. De fait, il ne s’agit pas ici de théorie ni d’anthropologie de l’architecture, mais à l’inverse, comme le promet le titre du texte, d’architecture anthropologique. Parcourant l’histoire des peuples et l’ordonnant selon trois « configurations » sociales et culturelles, Jean Stillemans établit que l’architecture, comme discipline, est désormais au temps de la théorie, et en particulier de l’anthropologie. L’exercice de l’architecture se déploie dans l’orbe d’un savoir anthropologique, ce qui fixe, pour demain, sinon un cap précis, du moins une orientation salutaire.

« Notre destin est de pister les commencements, les aubes — de saisir les fonctions humaines avant qu’un sens de bon sens ne vienne les recouvrir : c’est le destin anthropologique (…) C’est dire que l’architecture dans notre monde, celui qui a distingué les fonctions anthropiques, ne peut que leur être fidèle et entamer des chants qui se méfient du charme des leurres. »
Efecto mediador del engagement entre la Felicidad Subjetiva y el Conflicto Trabajo – Familia/ Familia- Trabajo en una muestra de profesores chilenos
Authors: Díaz Francisco Javier , Carrasco Moises Esteban
Published: September 2023

Este estudio analizó el efecto mediador del engagement en la relación entre felicidad subjetiva percibida y conflicto familia trabajo (CFT) trabajo- familia (CTF). La muestra fue de 273 profesores de la ciudad de Los Ángeles, Chile. Se aplicaron tres escalas previamente validadas en el medio nacional y se realizaron modelos de regresión lineal y ecuaciones estructurales para probar las diferentes hipótesis. Los principales resultados evidencian que existe un efecto mediador del engagement sobre la relación entre la felicidad subjetiva percibida y el CFT/CTF, evidenciando en los análisis de regresión que el entusiasmo presenta un rol predictor en las distintas causas del conflicto.
Editorial No. 38
Authors: Rosado Mendinueta Nayibe , Arias María Alejandra
Published: September 2023

Estimados y estimados lectores (as) de Zona Próxima, con esta edición número 38 iniciamos 2023. Año en el que seguramente cada uno de los miembros de esta comunidad académica seguirá? avanzando en sus proyectos personales y profesionales. Es menester agradecer a los investiga- dores que con creatividad y rigor siguen explorando temas desde perspectivas, enfoques teóricos y metodológicos diversos que se constituyen en valiosos aportes para comprender la compleja realidad que nos circunda.
Construcción de paz y memoria histórica desde la escuela: un recorrido histórico
Authors: Restrepo Valencia Marleny , Espinosa Ortega Angie Zulieth
Published: September 2023

Con base en numerosos estudios, tratados y proyectos en el mundo, consultados minuciosamente- te en diversos buscadores y paginas oficiales de organismos internacionales, se busca entender el cara y sello de las escuelas: 1. Su afectación por los conflictos armados y los desafíos que esto les genera y 2. Los aportes resilientes para la construcción de paz y memoria histórica. El objetivo de este texto es analizar cómo se han venido abordando estas temáticas, las cuales, respectivamente- te, constituyen las etapas de construcción del artículo. Los resultados muestran que, si bien hay contribuciones desde diversas partes del mundo, Colombia se destaca en la aplicación de este tipo de metodologías resilientes en los entornos educativos, mostrando gran bagaje de estudios y proyectos en las zonas y poblaciones mayormente afectadas por el conflicto armado.
Kilka uwag na temat recepcji twórczości Owidiusza w chrześcijańskeij poezji nowołacińskiej doby baroku
Authors: Milewska-Waźbińska Barbara
Published: September 2023

In the Neo-Latin poetry written from the fifteenth to the eighteenth centuries, one can find numerous references to the works of Ovid. The aim of this article is to reflect on the ways works by the famous Roman poet were received in Neo-Latin Christian literature of the Baroque period. The article discusses three poetry cycles inspired especially by Ovid`s elegies. Ovidius Christianus, whose author is the Jesuit Laurent Le Brun, refers to the Bible and informs about the New World in the form of poetic letters. Ovidius Christianus by Johannes Baptista Bebber presents in the form of elegies the moral principles of Thomas à Kempis contained in his work De imitatione Christi. The third item described is the booklet Novum liber tristium, which contains a series of seven elegies dedicated to the sorrows of Our Lady. The author of the article tries to show how the works of Ovid influenced the poetic imagination of Christian authors.
Przedstawienia i symbolika roślin w poezji Pindara
Authors: Stuligrosz Magdalena
Published: September 2023

The extensive use of plant motifs is at the heart of Pindar’s poetic images and metaphors. In his epinicions, the poet uses the symbolism of plants associated with Olympian and Pythian games to praise the victor and to show the importance of his achievement. The olive and laurel wreaths with which the victorious athletes are crowned become symbols of excellence and of the immortal fame accompanying human achievements, which is guaranteed by the poet’s song. Spring flowers such as roses and violets have a specific ritual meaning in Pindar’s cult songs, especially in his dithyrambs, where they symbolize vitality and rebirth. Aside from the plants typical of Greek flora, the Theban poet mentions those with miraculous properties, distinguished by their golden colour, which are associated with the divine and characteristic of sacred places and mythical landscape with paradisical connotations. Therefore, the symbolic meaning of floral imagery in Pindar’s Laments and in some passages from his victory songs cannot be recognized without taking into account its eschatological context.
The Tort of Discrimination
Authors: Dagan Hanoch , Dorfman Avihay
Published: September 2023

This Essay integrates two ambitions: to lay out new theoretical foundations for antidiscrimination law and to demonstrate the practical significance of these foundations to tackle instances of wrongful discrimination beyond the reach of the current legal regime. Concerning theory, we articulate an account of wrongful discrimination grounded in private law’s basic commitment to reciprocal respect for the self-determination and substantive equality of private persons. Concerning practice, we argue that antidiscrimination law is currently at its pre-MacPherson v. Buick stage, meaning it is made up of isolated pockets of liability for discriminatory behavior. The gaps between them are indefensible since they necessarily undermine people’s fundamental right to be treated as equals by holders of normative powers such as proprietors, employers, and lessors. Nothing short of a full-blown tort of discrimination will enable antidiscrimination law to reach its own MacPherson moment. The theoretical account we develop provides the necessary framework for embarking on this crucial endeavor: a clear articulation of the normative foundations of this tort as an integral and indispensable part of private law in a liberal society. Drawing on existing tort doctrines, we identify important legal tools that can be utilized for prescribing the proper elements—duty, breach, injury, causation, and remedy—of a novel, generic tort of discrimination.
Bifurcation analysis and control of the valve-controlled hydraulic cylinder system
Authors: Han Qin , Zhang Liang
Published: September 2023

This article discusses the bifurcation analysis and control of a valve-controlled hydraulic cylinder system. The dynamic system of the valve-controlled hydraulic cylinder is established. Normal form theory and Hopf bifurcation theory are used to analyse the bifurcation characteristic at equilibria of the system. Then, a dynamic-state feedback control method is proposed. A nonlinear controller is set for the system to control the bifurcation with the method. By adjusting the control parameters, the delay of model bifurcation and the stability of the system can be changed. Numerical analysis verifies the correctness of bifurcation control.
Effects of Medicine Wall Ball Throws With Whole-Body Vibration on Bat Swing Performance in Collegiate Baseball Players
Authors: Buso Dominick , Willardson Jeffrey M. , Shafer Alex B.
Published: September 2023

Buso, D, Willardson, JM, and Shafer, AB. Research note: Effects of medicine wall ball throws with whole-body vibration on bat swing performance in collegiate baseball players. J Strength Cond Res 37(10): 2071–2075, 2023—The purpose of this study was to examine the effect of medicine ball wall throws performed with whole-body vibration on bat swing performance in 13 highly trained collegiate baseball players. The experimental session involved the athletes' usual warm-up followed by baseline bat swings. The baseline bat swings were followed by 3 sets of 5 medicine ball wall throws while standing on a whole-body vibration platform set at 40 Hz and with 30 seconds rest between sets. Subjects then rested passively for 5 minutes before taking post-test bat swings. Performance was evaluated with bat speed (m·second−1), time to contact (secs), rotational acceleration (G's), and exit velocity (m·second−1). Paired t tests were used to compare baseline and post-test values (p ≤ 0.05). Effect size (d) statistics were also calculated to determine the magnitude of treatment effects. It was found that bat speed (p = 0.02; d = 0.22) and exit velocity (p = 0.03; d = 0.48) were significantly faster versus baseline, whereas rotational acceleration (p = 0.10; d = 0.23) and time to contact (p = 0.44; d = −0.12) were not significantly different from baseline, respectively. These results suggest that the addition of medicine ball wall throws with whole-body vibration can significantly increase key parameters of bat swing performance. Practitioners and coaches may consider including these combined exercise stimuli as part of workouts or during games for potentially greater success at the plate.
Editorial
Authors: Hellebrandt Luceni
Published: September 2023

Editorial do v. 11, n.1, 2023 - Dossiê: "Pesaca Artesanal: territórios, gestão, conflitos e gênero"
Moralidades em disputa
Authors: Beatriz Mendonça Silvia
Published: September 2023

O presente texto é produto de análises decorrentes de pesquisa de campo na comunidade tradicional da Vila do Araçá, em Porto Belo/SC/Brasil. O objetivo central desta foi acessar os sistemas de conhecimento e os modos de organização desse povoado para desenvolver as atividades de pesca que promovem o sustento cotidiano de suas famílias. Procura-se compreender as relações comunitárias e o sentimento de pertença a este espaço geográfico. Acessando então a relação dessas pessoas com o território e uso que fazem do ecossistema, busca-se verificar se há interferências geradas a partir da instalação de Unidades de Conservação no território da comunidade, sua relação com a legislação ambiental que desde a década de 1930 restringem práticas pesqueiras outrora comuns, bem como com os processos de urbanização e turismo da região, que passam a ocorrer a partir da década de 1980.
Single-Cell RNA-Sequencing Integration Analysis Revealed Immune Cell Heterogeneity in Five Human Autoimmune Diseases
Authors: Luo Siweier , Wang Le , Xiao Yi , Cao Chunwei , Liu Qinghua , Zhou Yiming
Published: September 2023

Background: Autoimmune diseases are a group of diseases caused by abnormal immune responses to functional body parts. Single-cell RNA-sequencing (scRNA-seq) technology provides transcriptomic information at the single-cell resolution, thus offering a new way to study autoimmune diseases. Most single-cell RNA-seq studies, however, have often focused on one type of autoimmune disease.

Methods: We integrated scRNA-seq data from peripheral blood cells of five different autoimmune diseases (IgA nephropathy [IgAN], Kawasaki disease [KD], multiple sclerosis [MS], Sjogren’s syndrome [SS], and systemic lupus erythematosus [SLE]). We performed dimensionality clustering, cellular communication analysis, re-clustering analysis of monocytes, NK cell populations, differential gene expression analysis, and functional enrichment for all immune cells in these data.

Results: We integrated the scRNA-seq results of peripheral blood cells from five different autoimmune diseases (IgAN, KD, MS, SS, and SLE). We showed that all samples contained 18 different immune cell subsets, although the cell cluster populations were different among the 5 diseases. Through intercellular communication network analysis, we determined that the signals of classical and non-classical monocytes were significantly enhanced in patients with IgAN and SLE. The signals of naïve B cells were increased in patients KD. Interestingly, the signals of NK and NK-T cells were enhanced in patients with SS, but reduced in patients with IgAN and SLE. Transcriptomic analysis of classical and non-classical monocyte subsets further revealed that pro-inflammatory cytokines and interferon-related genes, including CCL3, IL1B, ISG15, and IFI6, were specifically increased in patients with IgAN and SLE. Unlike monocytes, the number and NK marker genes were decreased in patients with IgAN and KD, but increased in patients with SS. Meanwhile, two NK-T cell subsets were exclusively found in SS.

Conclusions: In summary, based on an integration of the single-cell RNA-seq results, we demonstrated changes in the immune cell landscape of five different autoimmune diseases with respect to immune cell subsets, populations, differentially-expressed genes, and the cell-to-cell communication network. Our data provide new insight to further explore the heterogeneity and similarity among different autoimmune diseases.
Pathophysiology of Alzheimer’s disease revealed by chemical exchange saturation transfer MRI
Authors: Zhuang Caiyu , Chen Beibei , Chen Yue , Zhang Xiaolei , Wu Renhua
Published: September 2023

Alzheimer’s disease (AD) is the most common neurodegenerative brain disorder that is characterized by the deposition of amyloid-β protein (Aβ) and neurofibrillary aggregates (tau). There is currently no cure for AD; however, early diagnosis and intervention may prevent progression to dementia. In addition to CSF and blood biomarkers, imaging techniques, such as PET, fMRI, volumetric MRI, and chemical exchange saturation transfer (CEST), have facilitated the early diagnosis of AD and provided essential information about the pathophysiology of AD. Indeed, CEST findings have helped clarify important aspects of the pathophysiology underlying AD. In this article we provide an in-depth review of different CEST applications, including endogenous CEST (APT, creatine-CEST, and glutamate-CEST) and exogenous CEST (angiopep2, glucose, and glymphatic system-related CEST), in further elucidating the pathophysiology of AD and discuss the potential of novel approaches.
Preparation of magnetic lignin-based adsorbents and its adsorption properties for dyes
Authors:   School of Environmental and Natural Resources, Zhejiang University of Science and Technology, Hangzhou 310023, China, Li J. , Qiu S. P. ,   School of Environmental and Natural Resources, Zhejiang University of Science and Technology, Hangzhou 310023, China, Zhao H. F. ,   School of Environmental and Natural Resources, Zhejiang University of Science and Technology, Hangzhou 310023, China, Guo D. L. ,   School of Environmental and Natural Resources, Zhejiang University of Science and Technology, Hangzhou 310023, China, Yan Z. Y. ,   School of Environmental and Natural Resources, Zhejiang University of Science and Technology, Hangzhou 310023, China, Wu J. H. ,   School of Environmental and Natural Resources, Zhejiang University of Science and Technology, Hangzhou 310023, China, Li J. ,   School of Environmental and Natural Resources, Zhejiang University of Science and Technology, Hangzhou 310023, China
Published: September 2023

In this study, the renewable magnetic lignin-based material with good properties and environmental friendliness was successfully prepared and used for the treatment of wastewater. Lignin nanospheres (LNS) were prepared from stearyl chloride esterified alkali lignin via self-assembly in the mixture and raspberry-like magnetic lignin microspheres (Fe3O4@SiO2-LNS) was successfully prepared by grafting LNS onto the surface of Fe3O4@SiO2 particles by chemical crosslinking, then was used as absorbent for Methylene blue (MB) and Rhodamine B (RhB) dyes. The results indicated that the Fe3O4@SiO2-LNS had excellent adsorptivity in alkaline solution, and the maximum adsorption capacities for MB and RhB were 258.40 mg·g-1 and 124.38 mg·g-1 , respectively. The Fe3O4@SiO2-LNS adsorbent can be recycled due to its good magnetism and the regeneration efficiency is over 85% after three cycles. Therefore, the prepared magnetic lignin-based adsorbent is a lowcost, high-efficiency and reusable adsorbent for wastewater treatment.