bluuebunny/crossref_metadata_2025 huggingface dataset:
Competing endogenous RNA (ceRNA) networks in Parkinson's disease: A systematic review
Authors: Asadi Mohammad Reza , Abed Samin , Kouchakali Ghazal , Fattahi Fateme , Sabaie Hani , Moslehian Marziyeh Sadat , Sharifi-Bonab Mirmohsen , Hussen Bashdar Mahmud , Taheri Mohammad , Ghafouri-Fard Soudeh , Rezazadeh Maryam
Published: January 2023

Parkinson's disease (PD) is a distinctive clinical syndrome with several causes and clinical manifestations. Aside from an infectious cause, PD is a rapidly developing neurological disorder with a global rise in frequency. Notably, improved knowledge of molecular pathways and the developing novel diagnostic methods may result in better therapy for PD patients. In this regard, the amount of research on ceRNA axes is rising, highlighting the importance of these axes in PD. CeRNAs are transcripts that cross-regulate one another via competition for shared microRNAs (miRNAs). These transcripts may be either coding RNAs (mRNAs) or non-coding RNAs (ncRNAs). This research used a systematic review to assess validated loops of ceRNA in PD. The Prisma guideline was used to conduct this systematic review, which entailed systematically examining the articles of seven databases. Out of 309 entries, forty articles met all criteria for inclusion and were summarized in the appropriate table. CeRNA axes have been described through one of the shared vital components of the axes, including lncRNAs such as NEAT1, SNHG family, HOTAIR, MALAT1, XIST, circRNAs, and lincRNAs. Understanding the multiple aspects of this regulatory structure may aid in elucidating the unknown causal causes of PD and providing innovative molecular therapeutic targets and medical fields.
Stress-altering anterior insular cortex activity affects risk decision-making behavior in mice of different sexes
Authors: Shi Tianyao , Feng Shufang , Zhou Zhonglin , Li Fengan , Fu Yuan , Zhou Wenxia
Published: January 2023

Stress can affect people’s judgment and make them take risky decisions. Abnormal decision-making behavior is a core symptom of psychiatric disorders, such as anxiety, depression, and substance abuse. However, the neuronal mechanisms underlying such impairments are largely unknown. The anterior insular cortex (AIC) is a crucial structure to integrate sensory information with emotional and motivational states. These properties suggest that AIC can influence a subjective prediction in decision-making. In this study, we demonstrated that stressed mice prefer to take more risky choices than control mice using a gambling test. Manipulating the neural activity of AIC or selectively inhibiting the AIC-BLA pathway with chemogenetic intervention resulted in alterations in risk decision-making in mice. Different sexes may have different decision-making strategies in risky situations. Endogenous estrogen levels affect emotional cognition by modulating the stress system function in women. We observed decision-making behavior in mice of different sexes with or without stress experience. The result showed that female mice did not change their choice strategy with increasing risk/reward probability and performed a lower risk preference than male mice after stress. Using the pharmacological method, we bilaterally injected an estrogen receptor (ER) antagonist that resulted in more risky behavior and decreased synaptic plasticity in the AIC of female mice. Our study suggested that the AIC is a crucial region involved in stress-induced alteration of decision-making, and estrogen in the AIC may regulate decision-making behavior by regulating synaptic plasticity.
Cerebral blood flow changes induced by high-frequency repetitive transcranial magnetic stimulation combined with cognitive training in Alzheimer's disease
Authors: Qin Yuanyuan , Ba Li , Zhang Fengxia , Jian Si , Zhang Min , Zhu Wenzhen
Published: January 2023

Background and purpose

Hypoperfusion of the posterior cingulate cortex (PCC) and precuneus has consistently been reported in patients with Alzheimer's disease (AD). Repetitive transcranial magnetic stimulation (rTMS) combined with cognitive training (COG) is effective in alleviating the symptoms of patients with mild AD. This study investigated the effects of rTMS-COG therapy on cerebral blood flow (CBF), with a special interest in the PCC/precuneus, and whether observed CBF changes are associated with changes in neuropsychological assessments in AD.

Materials and methods

Twenty-one patients with mild or moderate AD were randomly divided into real rTMS (n = 11) and sham treatment (n = 10) groups, both combined with COG. Neuro-navigated 10 Hz rTMS was used to stimulate the left dorsolateral prefrontal cortex (DLPFC) and then the left lateral temporal lobe (LTL) for 20 min each day for 4 weeks in the real rTMS group. All patients with AD underwent neuropsychological assessment, pseudo-continuous arterial spin labeling, and structural 3D T1-weighted MRI before treatment (T0), immediately after treatment (T1), and 4 weeks after treatment (T2). CBF in the precuneus, PCC, and stimulation targets at the region-of-interest (ROI) level, as well as whole-brain CBF changes at the voxel level, were compared between the two groups at three timepoints.

Results

rTMS-COG therapy revealed significant group × time interactions for the Mini-Mental State Examination (F = 5.339, p = 0.023, η2 = 0.433) and activities of daily living (F = 5.409, p = 0.039, η2 = 0.436) scores. The regional CBF in the precuneus showed a significant group × time interaction (F = 5.833, p = 0.027, η2 = 0.593). For voxel-level analysis, a significant group main effect was found in the left limbic lobe cluster, with the maximal peak in the left parahippocampus (p < 0.001, uncorrected, peak at [−16 −8 −24]). Simple effects analysis indicated that rTMS-COG therapy induced a decrease in CBF in the precuneus at T1 (p = 0.007) and an increase in the left parahippocampus at T2 (p=0.008). CBF decrease in the precuneus was correlated with better cognitive function immediately after treatment (T1) (r =−0.732, p=0.025).

Conclusion

Neuropsychological assessments showed immediate and long-term effects on cognitive function and activities of daily living after rTMS-COG therapy. CBF changes induced by high-frequency rTMS-COG therapy are region-dependent, showing immediate effects in the precuneus and long-term effects in the left parahippocampus. These results provide imaging evidence to understand the underlying neurobiological mechanism for the application of rTMS-COG in AD.
Using fNIRS to evaluate ADHD medication effects on neuronal activity: A systematic literature review
Authors: Poliakova Eva , Conrad Amy L. , Schieltz Kelly M. , O'Brien Matthew J.
Published: January 2023

Background

Functional near infrared spectroscopy (fNIRS) is a relatively non-invasive and inexpensive functional neuroimaging technique that has shown promise as a method for understanding the differences in neuronal activity associated with various neurodevelopmental conditions, including ADHD. Additionally, fNIRS has been suggested as a possible tool to understand the impact of psychotropic medications on brain activity in individuals with ADHD, but this approach is still in its infancy.

Objective

The purpose of this systematic literature review was to synthesize the extant research literature on the use of fNIRS to assess the effects of ADHD medications on brain activity in children and adolescents with ADHD.

Methods

A literature search following Preferred Reporting Items for Systematic Literature Reviews and Meta-Analyses (PRISMA) guidelines was conducted for peer-reviewed articles related to ADHD, medication, and fNIRS in PsychInfo, Scopus, and PubMed electronic databases.

Results

The search yielded 23 published studies meeting inclusion criteria. There was a high degree of heterogeneity in terms of the research methodology and procedures, which is explained in part by the distinct goals and approaches of the studies reviewed. However, there was also relative consistency in outcomes among a select group of studies that demonstrated a similar research focus.

Conclusion

Although fNIRS has great potential to further our understanding of the effects of ADHD medications on the neuronal activity of children and adolescents with ADHD, the current research base is still relatively small and there are limitations and methodological inconsistencies that should be addressed in future studies.
Nutritional and lifestyle management of the aging journey: A narrative review
Authors: Kassis Amira , Fichot Marie-Claire , Horcajada Marie-Noelle , Horstman Astrid M. H. , Duncan Peter , Bergonzelli Gabriela , Preitner Nicolas , Zimmermann Diane , Bosco Nabil , Vidal Karine , Donato-Capel Laurence
Published: January 2023

With age, the physiological responses to occasional or regular stressors from a broad range of functions tend to change and adjust at a different pace and restoring these functions in the normal healthy range becomes increasingly challenging. Even if this natural decline is somehow unavoidable, opportunities exist to slow down and attenuate the impact of advancing age on major physiological processes which, when weakened, constitute the hallmarks of aging. This narrative review revisits the current knowledge related to the aging process and its impact on key metabolic functions including immune, digestive, nervous, musculoskeletal, and cardiovascular functions; and revisits insights into the important biological targets that could inspire effective strategies to promote healthy aging.
Exploring the molecular mechanism of Gan Shuang granules for the treatment of non-alcoholic steatohepatitis using network pharmacology, molecular docking, and experimental verification
Authors: Zhi Guoguo , Shao Bingjie , Zheng Tianyan , Mu Jie , Li Jingwei , Feng Yiyuan , Zhu Sha , Dang Yanni , Liu Feng , Wang Dong
Published: January 2023

Background: With the gradual increase in prevalence in recent years, non-alcoholic steatohepatitis (NASH) has become one of the significant health problems that urgently needs to be addressed worldwide. GanShuang Granules (GSG) is derived from the classical Chinese formula Xiaoyao San and mainly used in the clinical treatment of chronic liver diseases.

Objective: In this study, we aim to gain a deeper insight into the inhibiting effects of GSG on non-alcoholic fatty liver disease (NAFLD) rats and preliminarily elucidate the underlying intervention mechanisms.

Methods: First, High performance liquid chromatography (UHPLC-Q/Orbitrap-MS/MS) was used for the active compounds prediction in GSG. Then the data was mapped to mzCloud database. The targets corresponding to GSG compounds were collected from public databases, along with disease genes for NAFLD. The core targets and molecular mechanisms of GSG for NAFLD treatment were predicted by protein-protein interaction (PPI) network, Gene Ontology (GO), and Kyoto Encyclopedia of Genes and Genomes (KEGG) functional enrichment analyses. Molecular docking of the core target-component interactions was simulated using AutoDock Vina software. The effect of GSG on NASH rats was evaluated by pathological staining and analysis of various index results. Finally, the candidate targets were further validated by ELISA and western blot (WB) analyses.

Results: Combining UHPLC-Q/Orbitrap-MS/MS data analysis and public database data, a total of 346 cross-targets were obtained, corresponding to 81 compounds. The subnetwork with an MCODE score of 53.623 is a potential core target group for this study. GO and KEGG enrichment analyses showed that the targets of GSG in NAFLD were mostly related to oxidative stress, the NF-κB signaling pathway, and the apoptosis signaling pathway. By integrating the results of network pharmacology analysis, the core objectives of this study mainly include AKT1, CASP9, TNF, and CASP8. The core ingredients are related to resveratrol and fisetin. The molecular docking results indicated key binding activity between AKT1-fisetin, AKT1-Resveratrol, and CASP8-fisetin. Moreover, GSG could improve the inflammatory status and restore the abnormal lipid accumulation of NAFLD/NASH liver, and these levels are further verified by pathological staining and detection of related indicators. Mechanistically, GSG could regulate protein expression levels in the liver for P65, p-P65, IKB, p-IKB, IKK, caspase-3, -8, -9, and cytochrome C, etc. It reflects the inhibitory effect of GSG on the NF-κB/IκB signaling pathway.

Conclusion: Our results suggested that GSG demonstrated therapeutic effects on NAFLD/NASH rats, and these may be mainly reflected in the inhibitory effects on the NF-κB/IκB signaling pathway and its downstream inflammation and apoptosis signals.
Introducing an n-type electron deceleration layer to enhance the luminous efficiency of AlGaN-based DUV-LEDs
Authors: Wang Qiao , Zhang Kang , Lin Dan , Liang Xihui , Liu Yunzhou , Zhang Shan , Wu Hualong , Zhao Wei
Published: January 2023

The internal quantum efficiency (IQE) of conventional AlGaN-based deep-ultraviolet (DUV) light-emitting diodes (LEDs) is seriously limited by the poor and inhomogeneous carrier injection. The typical solution is to optimize the structure parameters of p-type region and active region. In this work, however, we try to address this issue by introducing an n-type electron deceleration layer (EDL) underneath multiple quantum wells (MQWs). On one hand, the electron deceleration layer helps to decrease the electron velocity and thus increase the electron capture rate. On the other hand, it can also reduce barrier heights in the band valence and thus enhance the hole transport in the multiple quantum wells. As a consequence, the concentrations of electrons and holes in the multiple quantum wells were significantly increased, resulting in the enhancement of radiative recombination. Compared to the conventional structure, the DUV-LED structure with an electron deceleration layer achieves a higher internal quantum efficiency, leading to a 39% improvement in the light output power. It is believed that performing energy-band engineering in n-type region has great application prospects for high-performance DUV-LEDs.
Gene coexpression analysis reveals key pathways and hub genes related to late-acting self-incompatibility in Camellia oleifera
Authors: Li Chang , Long Yi , Lu Mengqi , Zhou Junqin , Wang Sen , Xu Yan , Tan Xiaofeng
Published: January 2023

Introduction

Self-incompatibility (SI) is an important strategy for plants to maintain abundant variation to enhance their adaptability to the environment. Camellia oleifera is one of the most important woody oil plants and is widely cultivated in China. Late acting self-incompatibility (LSI) in C. oleifera results in a relatively poor fruit yield in the natural state, and understanding of the LSI mechanism remains limited.

Methods

To better understand the molecular expression and gene coexpression network in the LSI reaction in C. oleifera, we conducted self- and cross-pollination experiments at two different flower bud developmental stages (3–4 d before flowering and 1 d before flowering), and cytological observation, fruit setting rate (FSR) investigation and RNA-Seq analysis were performed to investigate the mechanism of the male −female interaction and identify hub genes responsible for the LSI in C. oleifera.

Results

Based on the 21 ovary transcriptomes, a total of 7669 DEGs were identified after filtering out low-expression genes. Weighted gene coexpression network analysis (WGCNA) divided the DEGs into 15 modules. Genes in the blue module (1163 genes) were positively correlated with FSR, and genes in the pink module (339 genes) were negatively correlated with FSR. KEGG analysis indicated that flavonoid biosynthesis, plant MAPK signaling pathways, ubiquitin-mediated proteolysis, and plant-pathogen interaction were the crucial pathways for the LSI reaction. Fifty four transcription factors (TFs) were obtained in the two key modules, and WRKY and MYB were potentially involved in the LSI reaction in C. oleifera. Network establishment indicated that genes encoding G-type lectin S-receptor-like serine (lecRLK), isoflavone 3’-hydroxylase-like (CYP81Q32), cytochrome P450 87A3-like (CYP87A3), and probable calcium-binding protein (CML41) were the hub genes that positively responded to the LSI reaction. The other DEGs inside the two modules, including protein RALF-like 10 (RALF), F-box and pectin acetylesterase (MTERF5), might also play vital roles in the LSI reaction in C. oleifera.

Discussion

Overall, our study provides a meaningful resource for gene network studies of the LSI reaction process and subsequent analyses of pollen−pistil interactions and TF roles in the LSI reaction, and it also provides new insights for exploring the mechanisms of the LSI response.
Injury and not the pathogen is the primary cause of corm rot in Crocus sativus (saffron)
Authors: Mansotra Ritika , Ali Tahir , Bhagat Nancy , Vakhlu Jyoti
Published: January 2023

Fusarium oxysporum has been reported to be the most devastating pathogen of Crocus sativus L., a commercially significant crop that yields the saffron spice. However, most of the pathogen isolations have been done from the diseased tissue, mostly from rotten corms, but no study has been conducted on diseased saffron fields. To fill the knowledge gap, the current study was carried out with the intention of recording the diversity of cultivable fungus species from saffron fields and screening them for pathogenicity towards saffron. The three study locations in Jammu and Kashmir, Srinagar (Pampore), Kishtwar, and Ramban, yielded a total of 45 fungal isolates. The internal transcribed spacer (ITS) of rDNA was used for the molecular identification. ITS rDNA-based sequence analysis classified all the operational taxonomic units (OTUs) into two phyla—Ascomycota (88.88%) and Mucoromycota (11.11%). Moreover, Fusarium (57.77%), Geotrichum (17.77%), Mucor (11.11%), Aspergillus (4.44%), Trichoderma (4.44%), Galactomyces (2.22%), and Colletotrichum (2.22%) all had different total abundances at the genus level. It was discovered that the saffron fields in Srinagar have fewer varied fungal species than the other two selected sites. All of the fungal isolates isolated including Fusarium solani, Aspergillus flavus, Trichoderma harzianum, Fusarium neocosmosporiellum, and Mucor circinelloides were pathogenic according to the pathogenicity test; however, injury to the saffron plant was found to be a must. These fungi were pathogenic in addition to F. oxysporum, which is well documented as a major cause of saffron corm rot diseases in Srinagar, but in the present study, injury was a must for F. oxysporum as well. The percentage disease severity index for both saffron roots and corms varied for each fungal isolate.
Factors influencing the satisfaction level of college students in China: Literature analysis based on grounded theory
Authors: Gu Qiongying , Lu Guodong
Published: January 2023

Student satisfaction is an important index for evaluating the quality of higher education and the competitiveness of colleges in China, and most of the current studies on the factors influencing the satisfaction level of colleges students adopt quantitative research methods. A qualitative analysis of 48 literatures on college students’ satisfaction was conducted using NVivo12 in this study. We found that the influencing factors of college students’ satisfaction in China are composed of seven dimensions: school reputation, school environment, personal improvement, organizational management, logistical support, teaching quality, and charges and subsidies. Among them, teaching quality, school environment, organizational management, and logistical support are the core categories. Furthermore, school reputation, school environment, organizational management, logistical support, teaching quality, and charges and subsidies are external factors, while personal improvement is an internal factor. To improve the satisfaction level of college students, the two dimensions of external and internal factors must be taken into account, with external factors being given more attention. This study not only expands the scope of scenarios to which the grounded theory has been applied, but also provides a reference for other scholars to conduct more in-depth empirical studies on college students’ satisfaction in Chinese colleges.
Adult friendship and wellbeing: A systematic review with practical implications
Authors: Pezirkianidis Christos , Galanaki Evangelia , Raftopoulou Georgia , Moraitou Despina , Stalikas Anastassios
Published: January 2023

This study aimed to systematically review research findings regarding the relationship between adult friendship and wellbeing. A multidimensional scope for wellbeing and its components with the use of the PERMA theory was adopted. A total of 38 research articles published between 2000 and 2019 were reviewed. In general, adult friendship was found to predict or at least be positively correlated with wellbeing and its components. In particular, the results showed that friendship quality and socializing with friends predict wellbeing levels. In addition, number of friends, their reactions to their friend's attempts of capitalizing positive events, support of friend's autonomy, and efforts to maintain friendship are positively correlated with wellbeing. Efforts to maintain the friendship, friendship quality, personal sense of uniqueness, perceived mattering, satisfaction of basic psychological needs, and subjective vitality mediated this relationship. However, research findings highlighted several gaps and limitations of the existing literature on the relationship between adult friendship and wellbeing components. For example, for particular wellbeing components, findings were non-existent, sparse, contradictory, fragmentary, or for specific populations only. Implications of this review for planning and implementing positive friendship interventions in several contexts, such as school, work, counseling, and society, are discussed.
The role of learner engagement with corrective feedback in EFL/ESL classrooms
Authors: Liu Hao , Feng Mengya
Published: January 2023

As corrective feedback (CF) is conducive to students’ second language (L2) development, a considerable number of studies have investigated the effects of different types of CF strategies on EFL/ESL learning achievement. However, the role of learner engagement has been largely neglected in the field of CF research. The present study aims to describe the role of learner engagement with CF in EFL/ESL classrooms by reviewing theoretical and empirical evidence. The findings reveal that learner engagement is indispensable for CF to be effective, and providing strategies for working with CF is essential to guide EFL/ESL learners in their learning process. The implications for teacher CF practice and learner engagement training are also discussed.
Mobile health solutions: An opportunity for rehabilitation in low- and middle income countries?
Authors: Bonnechère Bruno , Kossi Oyene , Mapinduzi Jean , Panda Jules , Rintala Aki , Guidetti Susanne , Spooren Annemie , Feys Peter
Published: January 2023

Mobile health (mHealth) development has advanced rapidly, indicating promise as an effective patient intervention. mHealth has many potential benefits that could help the treatment of patients, and the development of rehabilitation in low- and middle-income countries (LMICs). mHealth is a low-cost option that does not need rapid access to healthcare clinics or employees. It increases the feasibility and rationality of clinical treatment expectations in comparison to the conventional clinical model of management by promoting patient adherence to the treatment plan. mHealth can also serve as a basis for formulating treatment plans and partially compensate for the shortcomings of the traditional model. In addition, mHealth can help achieve universal rehabilitation service coverage by overcoming geographical barriers, thereby increasing the number of ways patients can benefit from the rehabilitation service, and by providing rehabilitation to individuals in remote areas and communities with insufficient healthcare services. However, despite these positive potential aspects, there is currently only a very limited number of studies performed in LMICs using mHealth. In this study, we first reviewed the current evidence supporting the use of mHealth in rehabilitation to identify the countries where studies have been carried out. Then, we identify the current limitations of the implementation of such mHealth solutions and propose a 10-point action plan, focusing on the macro (e.g., policymakers), meso (e.g., technology and healthcare institutions), and micro (e.g., patients and relatives) levels to ease the use, validation, and implementation in LMICs and thus participate in the development and recognition of public health and rehabilitation in these countries.
Evaluating computing students' digital skills and health literacy: A case from Bulgaria
Authors: Kaloyanova Kalinka , Leventi Nikoleta , Kaloyanova Elitsa
Published: January 2023

The main purpose of this article is to describe the importance and the challenges of digital health literacy as recognized during the COVID-19 pandemic. First, basic definitions of health literacy and digital health literacy are provided, followed by, and matched against digital competence frameworks, and health literacy skills content and scales. Based on that, a compatibility analysis is provided, against the expectations for satisfactory levels definition for the respective competences and skills. For the approbation of the approach, results received from the participation of computing students at the Sofia University St. Kliment Ohridski in the COVID-19 Health Literacy Survey are used.
The necessity revealed by COVID-19 pandemic: Paradigm shift of Iran's healthcare system
Authors: Mohammadpour Mohammadtaghi , Delavari Sajad , Kavosi Zahra , Peyravi Mahmoudreza , Izadi Reyhane , Bastani Peivand
Published: January 2023

Background

COVID-19 pandemic has resulted in drastic changes around the world, revealing vulnerable aspects of healthcare systems. This study aimed to explore how Iranian healthcare system experienced the paradigm shift during the pandemic and determine the aspects that need improvement during the pandemic era.

Method

This qualitative study was conducted in 2021. A framework analysis approach was used to analyze the content of the 19 semi-structured interviews with the healthcare system experts from Shiraz University of Medical Sciences (SUMS). The interviews‘ audio files changed into transcript after each session and data was saturated at the 19 interview. To increase the trustworthiness of the study, Guba and Lincoln's criteria including credibility, transferability, dependability, and confirmability were used. Goldsmith's five-step framework analysis was used applying MAX QDA version 10 software.

Result

Eight main themes and 20 subthemes were explored. The main themes included “strengthening the electronic health infrastructure,” “research for evidence-based decision making,” “dedicated financing to the pandemic,” “prevention of disruption in the effective provision of services and medicines,” “enriching the authority of the Ministry of Health by focusing on interactions,” “recruiting, managing and empowering health human resources with attention to financial and non-financial incentives,” “reforming educational approaches in training students in medical universities,” as well as “lessons learned from neglected aspects.”

Conclusion

To be ready to respond to a possible future pandemic and for a paradigm shift, bold steps must be taken to make fundamental changes in various aspects of the healthcare system including e-health development, evidence-based decision making, dedicated budgets for pandemics, reinforcement of interactions at the national and international level, as well as sufficient attention to healthcare workers from all financial, non-financial and educational aspects.
Does environmental regulation improve public health? Evidence from China's Two Control Zones policy
Authors: Yang Ningze , Liu Ziwei , Lin Yuxi , Yang Yongliang
Published: January 2023

Improving public health is the premise of sustainable human development and an essential condition of economic growth. However, increasing severe environmental pollution poses a threat to public health. Implementing environmental regulation policy has become a meaningful way to control environmental pollution and the basis and guarantee for achieving public health. This paper aims to study the impact of environmental regulation on public health. The Two Control Zones (TCZ) policy is the earliest and stricter environmental regulation in China. Based on the policy experiment of TCZ, this paper analyzes the role of TCZ policy in improving public health using the DID model and data from 112 cities. The study finds that the TCZ policy can significantly improve public health, and this improvement effect was continuous and lagging. The results of benchmark regression show that the implementation of the TCZ policy has reduced the incidence rate of respiratory diseases in TCZ areas by 5.7%. When considering city heterogeneity in terms of economic and geographical conditions, the study further found that the impact of improvement is largest for cities in more heavily non-provincial capital and central and western regions, respectively. In addition, the results of mediating test show that TCZ policy improves public health by reducing environmental pollution. Our research fills the gap in the literature on the micro effects of environmental regulation policy on public health in developing countries. The government should prioritize environmental pollution control through reasonable environmental regulation policies. The government should strengthen environmental information disclosure to remind the public to deal with air pollution. The government and enterprises also should take various environmental protection measures to reduce air pollution emissions.
Food insecurity and its socioeconomic and health determinants in pregnant women and mothers of children under 2 years of age, during the COVID-19 pandemic: A systematic review and meta-analysis
Authors: Azevedo Francilene Maria , Morais Núbia de Souza de , Silva Debora Leticia Frizzi , Candido Aline Carare , Morais Dayane de Castro , Priore Silvia Eloiza , Franceschini Sylvia do Carmo Castro
Published: January 2023

Background

The COVID-19 pandemic has reduced access to adequate food in terms of quality and quantity, especially for the most vulnerable population groups. The objective of this study was to evaluate the prevalence of Food Insecurity and its main socioeconomic and health determinants in pregnant women and mothers of children under 2 years of age, during the COVID-19 pandemic.

Methods

This systematic review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) and registered in the International Prospective Register of Systematic Reviews (PROSPERO) (CRD42021278033). The descriptors “Pregnant Woman”, “Postpartum Women”, “Breastfeeding Women”, “COVID-19”, “Food Insecurity”, “Food Security” were combined in Scopus (Elsevier), Medline/PubMed (via National Library of Medicine), Embase (Elsevier), Web of Science and Science Direct independently by two researchers in September 2022. Original articles about Food Insecurity in households with pregnant women and mothers of children under 2 years of age during the COVID-19 pandemic were included. The meta-analysis of the prevalence of Food Insecurity was conducted using the RStudio software (4.0.4).

Results

The initial search resulted in 539 records, and 10 articles met the proposed criteria and were included in this review. The prevalence of Food Insecurity ranged from 11.5 to 80.3% and in the meta-analysis it was 51% (IC: 30–71) (I2 = 100.0%). The main socioeconomic and health determinants were ethnicity, domain language, low education, low income, informal employment, unemployment, occurrence of mental disorders, domestic violence, in addition to the unavailability of food in markets and lack of transport. The inclusion of studies with data collection by telephone stands out as a limitation, due to the non-inclusion of vulnerable groups without access to this means of communication.

Conclusion

It is necessary to implement and strengthen specific public policies for the maternal and child group with the objective of protecting and strengthening the rights of women to maintain the physical and mental integrity of this group and guarantee Food Security.
Hybridizing five neural-metaheuristic paradigms to predict the pillar stress in bord and pillar method
Authors: Zhou Jian , Chen Yuxin , Chen Hui , Khandelwal Manoj , Monjezi Masoud , Peng Kang
Published: January 2023

Pillar stability is an important condition for safe work in room-and-pillar mines. The instability of pillars will lead to large-scale collapse hazards, and the accurate estimation of induced stresses at different positions in the pillar is helpful for pillar design and guaranteeing pillar stability. There are many modeling methods to design pillars and evaluate their stability, including empirical and numerical method. However, empirical methods are difficult to be applied to places other than the original environmental characteristics, and numerical methods often simplify the boundary conditions and material properties, which cannot guarantee the stability of the design. Currently, machine learning (ML) algorithms have been successfully applied to pillar stability assessment with higher accuracy. Thus, the study adopted a back-propagation neural network (BPNN) and five elements including the sparrow search algorithm (SSA), gray wolf optimizer (GWO), butterfly optimization algorithm (BOA), tunicate swarm algorithm (TSA), and multi-verse optimizer (MVO). Combining metaheuristic algorithms, five hybrid models were developed to predict the induced stress within the pillar. The weight and threshold of the BPNN model are optimized by metaheuristic algorithms, in which the mean absolute error (MAE) is utilized as the fitness function. A database containing 149 data samples was established, where the input variables were the angle of goafline (A), depth of the working coal seam (H), specific gravity (G), distance of the point from the center of the pillar (C), and distance of the point from goafline (D), and the output variable was the induced stress. Furthermore, the predictive performance of the proposed model is evaluated by five metrics, namely coefficient of determination (R2), root mean squared error (RMSE), variance accounted for (VAF), mean absolute error (MAE), and mean absolute percentage error (MAPE). The results showed that the five hybrid models developed have good prediction performance, especially the GWO-BPNN model performed the best (Training set: R2 = 0.9991, RMSE = 0.1535, VAF = 99.91, MAE = 0.0884, MAPE = 0.6107; Test set: R2 = 0.9983, RMSE = 0.1783, VAF = 99.83, MAE = 0.1230, MAPE = 0.9253).
The association between chronic disease and depression in middle-aged and elderly people: The moderating effect of health insurance and health service quality
Authors: Li Dongxu , Su Min , Guo Xi , Liu Bin , Zhang Tianjiao
Published: January 2023

Background

Depression in chronic disease patients was an important public health problem. However, limited work has been done on how to alleviate the depression of chronic disease patients. This paper attempted to explore the alleviating effect of health insurance and health service quality.

Methods

A total of 11,500 middle-aged and elderly people were drawn from four waves (2011, 2013, 2015, and 2018) of the China Health and Retirement Longitudinal Study (CHARLS). We analyzed the effect of chronic disease on depression in middle-aged and elderly people in China, and explored the mechanism of action from health insurance and health service quality.

Results

After adjusting for sociodemographic factors, any chronic disease (coefficient 1.471, p < 0.01) and multiple chronic diseases (coefficient 1.733, p < 0.01) could significantly increase the depression score. Any chronic disease increased the depression score (165.3 and 147.4% in non-health insurance group and health insurance group, respectively), the multiple chronic diseases increased the depression score (190.6 and 173.5% in non-health insurance group and health insurance group, respectively). Any chronic disease increased the depression score (161.3 and 139.5% in lower health service quality group and higher health service quality group, respectively), the multiple chronic diseases increased the depression score (228.4 and 162.9% in lower health service quality group and higher health service quality group, respectively). And similar results were obtained after using depression status instead of depression score.

Conclusions

Chronic disease and multiple chronic diseases were important determinants of depression in middle-aged and elderly people. Health insurance and health service quality were the key factors in relieving the depression of chronic disease patients. Several strategies were urgently needed: paying attention to the mental health of chronic disease patients, increasing the participation rate of health insurance, further improving the quality of health service, and alleviating the psychological harm caused by chronic disease.
Interventions for promoting and optimizing breastfeeding practices: An overview of systematic review
Authors: Khatib Mahalaqua Nazli , Gaidhane Abhay , Upadhyay Shilpa , Telrandhe Shital , Saxena Deepak , Simkhada Padam Prasad , Sawleshwarkar Shailendra , Quazi Syed Zahiruddin
Published: January 2023

Background

Optimal breastfeeding (BF) practices are essential for child survival and proper growth and development. The purpose of this overview is to evaluate the effectiveness of different interventions for promoting and optimizing breastfeeding.

Methods

We included systematic reviews (SRs) [including trials from Low-Income (LICs) and Low Middle-Income countries (LMICs)] that have evaluated the effect of various interventions for promoting and optimizing breastfeeding and excluded non-systematic reviews, and SRs based on observational studies. We searched various electronic databases. We followed the standard methodology as suggested by the Cochrane Handbook for Systematic Reviews of Interventions. Two sets of reviewers undertook screening followed by data extraction and assessment of the methodological quality of included SRs.

Result

We identified and screened 1,002 Cochrane SRs and included six SRs in this overview. Included SRs reported only two of the primary outcomes, early initiation of breastfeeding (EIBF) and/or exclusive breastfeeding (EBF). None of the included SR reported continued BF up to 2 years of age. The results were evaluated using two major comparisons groups: BF intervention against routine care and one type of BF intervention vs. other types of BF intervention. Overall results from included SRs showed that there were improvements in the rates of EIBF and EBF among women who received BF intervention such as BF education sessions and support compared to those women who received only standard care. However, BF intervention via mobile devices showed no improvements. In Target Client Communication (TCC) via mobile devices intervention group, no significant improvements were reported in BF practices, and also the reported evidence was of very low certainty.

Conclusion

Community Based Intervention Packages (CBIP) delivered to pregnant and reproductive-age women during their Antenatal care (ANC) and/or Postnatal care (PNC) periods by Ancillary Nurse-Midwives reported the highest improvement in EIBF compared to women who received standard care. However, insufficient evidence was reported to suggest that BF intervention showed improvements in EBF in both the comparison groups. This overview highlighted the gaps in primary research regarding the uncertainty about the settings such as LICs or LMICs, lack of evidence from LMICs, and also identified gaps in the availability of reliable up-to-date SRs on the effects of several BF interventions to promote and optimize practices.

Systematic review registration

https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42020174998, PROSPERO [CRD42020174998].
Singularity analysis of 3-DOF planar parallel continuum robots with constant curvature links
Authors: Lilge Sven , Wen Kefei , Burgner-Kahrs Jessica
Published: January 2023

This paper presents the singularity analysis of 3-DOF planar parallel continuum robots (PCR) with three identical legs. Each of the legs contains two passive conventional rigid 1-DOF joints and one actuated planar continuum link, which bends with a constant curvature. All possible PCR architectures featuring such legs are enumerated and the kinematic velocity equations are provided for each of them. Afterwards, a singularity analysis is conducted based on the obtained Jacobian matrices, providing a geometrical understanding of singularity occurences. It is shown that while loci and occurrences of type II singularities are mostly analogous to conventional parallel kinematic mechanisms (PKM), type I singularity occurences for the PCR studied in this work are quite different from conventional PKM and less geometrically intuitive. The study provided in this paper can promote further investigations on planar parallel continuum robots, such as structural design and control.
EXOSpy: A python package to investigate the terrestrial exosphere and its FUV emission
Authors: Cucho-Padin Gonzalo , Bhattacharyya Dolon , Sibeck David G. , Connor Hyunju , Youngblood Allison , Ardila David
Published: January 2023

The exosphere is the uppermost layer of the terrestrial atmosphere, mainly composed of atomic hydrogen (H) that resonantly scatters solar far-ultraviolet (FUV) photons at 121.56 nm, also referred to as Lyman-Alpha (Ly-α) emission. Analysis of this emission has been used to determine the global, three-dimensional, and time-dependent exospheric H density structure, which is essential to assess the permanent escape of H to space as well as to determine their role in governing the transient response of terrestrial plasma environment to space weather. Thus, Ly-α emission and its by-product, the H density, are highly desirable to the magnetospheric community. On the other hand, this emission can also be regarded as a significant source of contamination during studies of FUV targets such as O/B-type stars, planetary and exoplanetary atmospheres, and the circumgalactic medium, especially when observations are acquired from Earth-orbiting instruments. In this case, accurate specification of exospheric Ly-α photon flux and its subsequent removal is required by the planetary and astrophysics community studying solar/extra-solar system objects. This work introduces EXOSpy, an open-source python-based package that provides several models of terrestrial exospheric H density and calculates exospheric Ly-α emission with a high potential to contribute to investigations in both communities. We present several examples to demonstrate how EXOSpy can be used to (i) validate current and new exospheric models based on actual Ly-α radiance data, (ii) estimate exospheric contamination for a given instrument’s line-of-sight and spatial location, and (iii) provide support for new space-based FUV instrument design.
The effect of small-sided games using the FIT LIGHT training system on some harmonic abilities and some basic skills of basketball players
Authors: Hassan Ahmed K. , Alibrahim Mohammed S. , Sayed Ahmed Yasser Abdul Rashid
Published: January 2023

Introduction

The aim of this research is to identify the effect of Small-sided games using the FITLIGHT training system on some of the harmonic abilities and some of the basic skills of basketball Players.

Methods

The researchers used the experimental method on 24 basketball players. They were randomly divided into two groups: one experimental (n = 12, age = 10.92 ± 0.79 years; height = 138.50 ± 2.78 cm; weight = 40.25 ± 2.01 kg) and a control group (n = 12, age = 11.17 ± 0. 72 years; length = 139.92 ± 3.53 cm; weight = 40.50 ± . 1.73 kg). The homogeneity between the two groups was calculated and showed that there were no differences between the two samples. In the research variables, the proposed program was applied for 10 weeks at the rate of 4 weekly training units.

Results and Discussion

The proposed training program had a positive impact on the harmonic abilities and basic skills of basketball players and the differences in improvement rates for all variables were in favor of the experimental group. Therefore, the research suggests that Small-sided games using FITLIGHT positively affect all the variables under research. This leads to significant differences between the post-tests and benefits the experimental group.
Superficial temporal artery–middle cerebral artery bypass in combination with encephalo-myo-synangiosis in Chinese adult patients with moyamoya disease
Authors: Li Lu , Wang Anji , Wang Changhui , Zhang Hanbin , Wu Deshen , Zhuang Guangliang , Wang Jie
Published: January 2023

Objective

To evaluate the feasibility and safety of superficial temporal artery (STA)–middle cerebral artery (MCA) anastomosis in combination with encephalo-myo-synangiosis (EMS) in Chinese adult patients with moyamoya disease (MMD).

Methods

A total of 65 patients with MMD who underwent combined STA–MCA bypass + EMS surgical revascularisation were included in this study. Each patient had a follow-up visit 6 months after discharge. Early bypass function was evaluated via computed tomography angiography and digital subtraction angiography, which were performed preoperatively and at 6 months after surgery. The perfusion parameters of cerebral blood flow (CBF), cerebral blood volume (CBV), mean transit time (MTT) and time to peak (TTP) were obtained and analysed. The clinical status of each patient was evaluated using a modified Rankin scale (mRS) preoperatively and at 1 week and 6 months after surgery.

Results

Among the 65 enrolled patients, postoperative complications were observed in 5 (7.69%) patients, with 2 cases of dysphasia, 2 cases of new cerebral infarction and 1 case of seizure. Six months after surgery, 66 out of 68 hemispheres were found to have a functioning extra-intracranial bypass, and the patency rate was 97.06%. In terms of CBF perfusion, both the CBF and CBV increased significantly, while the MTT and TTP decreased after surgery. The mRS scores measured 1 week and 6 months after surgery were much lower than those measured preoperatively.

Conclusion

A direct STA–MCA bypass procedure in combination with indirect EMS bypass is feasible and safe for Chinese adult patients with MMD.