bluuebunny/crossref_metadata_2025 huggingface dataset:
Are Opioids Agitating? A Data Analysis of Baseline Data from the STAN Study
Authors: Lesage Myriam , Cinalioglu Karin , Chan Sabrina , Kumar Sanjeev , Rajji Tarek , Melichercik Ashley , Desjardins Carmen , Friedland Jess , Burhan Amer , Colman Sarah , Chu Li , Davies Simon , Derkach Peter , Elmi Sarah , Gerretsen Philip , Graff-Guerrero Ariel , Hussain Maria , Ismail Zahinoor , Kim Donna , Krisman Linda , Moghabghab Rola , Mulsant Benoit H. , Pollock Bruce G. , Rostas Aviva , Van Bussel Lisa ,   StaN Study Group, Rej Soham
Published: September 2024

Agitation, a common dementia symptom often arising from untreated pain, lacks comprehensive research on its connection with opioids prescribed for long-term pain. This study investigated the relationship between opioid use and agitation in dementia patients. Participants ( n = 188) were categorized into opioid, acetaminophen PRN, or no-pain medication groups. Despite higher reported pain levels in the opioid group, no significant differences in agitation were observed among the groups. In conclusion, opioid use for pain management in older adults with dementia did not significantly impact agitation, emphasizing the ongoing importance of proper pain management in improving dementia care and addressing agitation in this population.
Cognitive Function After Stopping Folic Acid and DHA Intervention: An Extended Follow-Up Results from the Randomized, Double Blind, Placebo-Controlled Trial in Older Adults with Mild Cognitive Impairment
Authors: Bai Dong , Fan Junting , Li Mengyue , Dong Cuixia , Gao Yiming , Fu Min , Liu Qianfeng , Liu Huan
Published: September 2024

Background:

Our previously randomized controlled trial (RCT) showed daily oral folic acid (FA), docosahexaenoic acid (DHA) and their combined treatment for 6 months could significantly improve cognitive function in mild cognitive impairment (MCI) individuals.

Objective:

This study aimed to evaluate whether this benefit seen in the treatment group would sustain after stopping intervention when patients returned to a real-world.

Methods:

RCT (ChiCTR-IOR-16008351) was conducted in Tianjin, China. 160 MCI elders aged ≥60 years were randomly divided into four groups: FA + DHA, FA, DHA, and control. 138 MCI elders who completed the 6-month interventional trial underwent another 6-month follow-up without receiving nutritional therapy. Cognitive performance was measured at 6 and 12 months. Blood amyloid-β peptide (Aβ) and homocysteine (Hcy) related biomarkers were measured at baseline and 6 months.

Results:

In comparison to the end of nutritional therapy, all intervention groups had considerably lower full-scale IQ, arithmetic, and image completion scores during the follow-up period, while the combined intervention and DHA groups had significantly lower picture arrangement scores. Furthermore, after 6-month treatment with FA and FA + DHA, plasma Aβ40, Aβ42, and Hcy levels were significantly decreased. However, these biomarker levels at the start of follow-up were positively correlated with the degree of cognitive function change during follow-up period.

Conclusions:

FA and DHA supplementation enhance cognitive performance in MCI elderly following a six-month intervention by reducing Hcy or Aβ levels. However, their effects on improving cognitive decline are likely to diminish when the intervention is discontinued.
Uncovering the link between human endogenous retroviruses, inflammatory pathways, and gastric cancer development
Authors: Li Zhengtai , Li Hongjiang , Fang Kun , Lin Xinglei , Yu Changyuan
Published: September 2024

BACKGROUND:

Endogenous retroviruses, previously deemed “junk” DNA, have gained attention in recent scientific studies. These inherited genomic elements are now recognized for their potential roles in diseases, especially cancer, highlighting their value as potential diagnostic or therapeutic targets.

OBJECTIVE:

This research aims to explore the association between human endogenous retroviruses (HERV) and gastric cancer, focusing on discerning HERV expression patterns and understanding their implications in gastric cancer pathology.

METHODS:

A quantitative analysis of HERV expression was conducted, employing Support Vector Machine (SVM) and AdaBoost algorithms to identify discriminative HERVs. The co-regulation network between protein-coding genes and HERVs was constructed using the Weighted Gene Co-expression Network Analysis (WGCNA).

RESULTS:

Three distinct HERVs (LTR16A[Formula: see text]72[Formula: see text]451, LTR91[Formula: see text]636[Formula: see text]874, LTR27D[Formula: see text]87[Formula: see text]222) were identified as significantly different. Strong correlations were found between HERVs, and gene sets enriched in the inflammatory pathway.

CONCLUSIONS:

HERVs appear to influence abnormal inflammatory responses, suggesting a pivotal role in gastric cancer development.
Blood endocan as a biomarker for breast cancer recurrence
Authors: Daiki Kentaro , Kanada Yoko , Nagata Aya , Taruno Kanae , Igarashi Katsuhide , Yamochi Toshiko , Ota Hirotaka , Sato Fumiaki , Nakamura Seigo , Kato Yoshinori
Published: September 2024

BACKGROUND:

Endocan was reported to affect breast cancer patients negatively and was able to be detected from patients’ blood.

OBJECTIVE:

This study aimed to investigate if the measurement of blood endocan in breast cancer patients with high ESM1 expression could be an effective tool to detect postoperative recurrence compared with existing tumor markers.

METHODS:

Blood was collected before and after the tumor resection from the mouse models of breast cancer, and endocan levels were measured while visualizing metastatic recurrence with noninvasive luminescence imaging. In clinical settings, blood was withdrawn from 16 breast cancer patients before and after the tumor resection, and the effect of lumpectomy on blood endocan level was evaluated. Additionally, the blood endocan from 20 patients diagnosed with postoperative recurrence was measured, and their positivity rate for endocan was compared with that for serum carcinoembryonic antigen (CEA) or cancer antigen 15-3 (CA15-3).

RESULTS:

Our preclinical and clinical experiments revealed that blood endocan levels reflected tumor burden. Furthermore, over 60% of patients suffering from postoperative recurrence who tested negative for CEA or CA15-3 were positive for endocan.

CONCLUSIONS:

Our results support the clinical significance of endocan in breast cancer patients for detecting breast cancer recurrence.
KIF18A promotes cervical squamous cell carcinoma progression by activating the PI3K/AKT pathway through upregulation of CENPE
Authors: Sun Fengyi , Zhao Tiantian
Published: September 2024

BACKGROUND:

Cervical cancer is a prevalent malignancy that significantly contributes to morbidity and mortality rates among women in developing nations. Although the association of KIF18A with various cancers has been established, its role in cervical squamous cell carcinoma (CESC) remains elusive.

METHODS:

The KIF18A impact on the progression of CESC and its underlying mechanism were investigated through comprehensive bioinformatics analysis utilizing publicly available datasets. The levels of KIF18A and CENPE were assessed in clinical CESC samples through western blotting and qRT-PCR. To discover the role and molecular pathways of KIF18A in CESC, a combination of experimental approaches, including wound-healing, flow cytometry, CCK-8, and Transwell assay, were employed.

RESULTS:

Our results demonstrate a significant KIF18A expression upregulation in CESC tissues in contrast to healthy tissues. In vitro, KIF18A upregulation was found to enhance cell growth, migration, and invasion and activate the PI3K/AKT signaling pathway while concurrently suppressing apoptosis. Conversely, downregulating KIF18A exhibited contrasting effects. Mechanistically, we observed a positive significant connection between KIF18A and CENPE in CESC cells.

CONCLUSION:

KIF18A promotes tumor growth in CESC by modulating the PI3K/AKT signaling pathway through regulation of CENPE, making it a potential biomarker for diagnosis and prognosis as well as a therapeutic target.
Response of Arthrospira platensis to nitrogen depletion and the effect of aqueous extracts on tumor and non-tumor cells
Authors: Zeitler Christina , Braune Steffen , Waldeck Peter , Jung Conrad G.H. , Küpper Jan-Heiner , Petrick Ingolf , Jung Friedrich
Published: September 2024

The microalgae Arthrospira platensis (AP), commonly known as Spirulina, has gained widespread popularity as a food supplement in recent years. AP is particularly abundant in protein, B vitamins, iron, magnesium, potassium, and various antioxidants. In this study we aimed to evaluate the effect of nitrate limitation in the AP culture medium on AP growth and composition. In addition, the cytotoxicity of the respective aqueous AP extracts on three different mammalian cell-lines (HepG2, Caco2, L929) was tested. AP was cultivated over a 10-day period under nitrogen-rich (Nrich: 1.8 g/L) and nitrogen-deficient (Nlimited: 0.2–0.4 g/L) conditions in two separate experiments, each with three biological replicates (three bioreactors). Throughout the cultivation, the kinetic progress of dry biomass, pH, pigment content, the levels of essential elements (sulphur, phosphate, and nitrate) and the composition of elements in the harvested biomass was determined. While the biomass slightly but significantly differed, the phycocyanin concentration differed considerably (around 10-fold higher in the Nrich medium, p < 0.05). Aqueous extracts of the Nrich medium had significantly stronger effects on the cell membrane integrity and the metabolic activity of the cells than extracts of the Nlimited medium. Particularly was the finding that AP had a significantly stronger toxic effect on the two tumour cell types (HepG2, Caco2) than on the non-tumour cells (L929). This study underscores the significance of nitrate content in the cultivation media of AP.
Detecting Amyloid Positivity Using Morphometric Magnetic Resonance Imaging
Authors: Pereira Helena Rico ,   for the Alzheimer’s Disease Neuroimaging Initiative, Diogo Vasco Sá , Prata Diana , Ferreira Hugo Alexandre
Published: September 2024

Background: Early detection of amyloid-β (Aβ) positivity is essential for an accurate diagnosis and treatment of Alzheimer’s disease (AD), but it is currently costly and/or invasive. Objective: We aimed to classify Aβ positivity (Aβ+) using morphometric features from magnetic resonance imaging (MRI), a more accessible and non-invasive technique, in two clinical population scenarios: one containing AD, mild cognitive impairment (MCI) and cognitively normal (CN) subjects, and another only cognitively impaired subjects (AD and MCI). Methods: Demographic, cognitive (Mini-Mental State Examination [MMSE] scores), regional morphometry MRI (volumes, areas, and thicknesses), and derived morphometric graph theory (GT) features from all subjects (302 Aβ+, age: 73.3±7.2, 150 male; 246 Aβ–, age: 71.1±7.1, 131 male) were combined in different feature sets. We implemented a machine learning workflow to find the best Aβ+ classification model. Results: In an AD+MCI+CN population scenario, the best-performing model selected 120 features (107 GT features, 12 regional morphometric features and the MMSE total score) and achieved a negative predictive value (NPVadj) of 68.4%, and a balanced accuracy (BAC) of 66.9%. In a AD+MCI scenario, the best model obtained NPVadj of 71.6%, and BAC of 70.7%, using 180 regional morphometric features (98 volumes, 52 areas and 29 thicknesses from temporal, parietal, and frontal brain regions). Conclusions: Although with currently limited clinical applicability, regional MRI morphometric features have clinical usefulness potential for detecting Aβ status, which may be augmented by a combination with cognitive data when cognitively normal subjects make up a substantial part of the population presenting for diagnosis.
Approaches to Early Parkinson’s Disease Subtyping
Authors: Hu Michele , Skjærbæk Casper , Borghammer Per
Published: September 2024

Parkinson’s disease (PD) unfolds with pathological processes and neurodegeneration well before the emergence of noticeable motor symptoms, providing a window for early identification. The extended prodromal phase allows the use of risk stratification measures and prodromal markers to pinpoint individuals likely to develop PD. Importantly, a growing body of evidence emphasizes the heterogeneity within prodromal and clinically diagnosed PD. The disease likely comprises distinct subtypes exhibiting diverse clinical manifestations, pathophysiological mechanisms, and patterns of α-synuclein progression in the central and peripheral nervous systems. There is a pressing need to refine the definition and early identification of these prodromal subtypes. This requires a comprehensive strategy that integrates genetic, pathological, imaging, and multi-omics markers, alongside careful observation of subtle motor and non-motor symptoms. Such multi-dimensional classification of early PD subtypes will improve our understanding of underlying disease pathophysiology, improve predictions of clinical endpoints, progression trajectory and medication response, contribute to drug discovery and personalized medicine by identifying subtype-specific disease mechanisms, and facilitate drug trials by reducing confounding effects of heterogeneity. Here we explore different subtyping methodologies in prodromal and clinical PD, focusing on clinical, imaging, genetic and molecular subtyping approaches. We also emphasize the need for refined, theoretical a priori disease models. These will be prerequisite to understanding the biological underpinnings of biological subtypes, which have been defined by large scale data-driven approaches and multi-omics fingerprints.
Association Between Body Mass Index Changes and All-Cause Mortality in Parkinson’s Disease
Authors: Yoon Seo Yeon , Choi Ja Young , Nam Ga Eun , Jung Jin-Hyung , Han Kyungdo , Kang Sung Hoon , Kim Chi Kyung , Kim Yong Wook , Koh Seong-Beom
Published: September 2024

Background:

Whether body weight changes are associated with Parkinson’s disease (PD) mortality remains uncertain.

Objective:

To investigate the association between changes in body mass index (BMI) and all-cause mortality in patients with PD.

Methods:

This nationwide cohort study enrolled 20,703 individuals with new-onset PD (ICD-10 code: G20 and a rare intractable disease registration code: V124) who underwent health screening program by the Korean National Health Insurance Service within two years from pre- and post-PD diagnosis. We identified nine BMI change groups based on three BMI status: underweight (BMI < 18.5 kg/m2), normal or overweight (18.5 kg/m2≤BMI < 25 kg/m2), and obese (BMI≥25 kg/m2).

Results:

Of 20,703 individuals, 3,789 (18.0%) died during the follow-up period. Excessive weight loss to underweight in the obese group (hazard ratio [HR] = 3.36, 95% CI:1.60–7.08), weight loss in the normal to overweight group (HR = 2.04, 95% CI:1.75–2.39), sustained underweight status (HR = 2.05, 95% CI:1.67–2.52), and weight gain from underweight to normal or overweight (HR = 1.52, 95% CI:1.15–2.02) were associated with increased mortality. Sustained obese status (HR = 0.80, 95% CI:0.74–0.87) and weight gain in the normal to overweight group (HR = 0.82, 95% CI:0.71–0.95) were associated with reduced mortality.

Conclusions:

We found that BMI change at diagnosis was associated with mortality in patients with PD. Specifically, being underweight either before or after diagnosis as well as experiencing weight loss, were associated with increased mortality. These findings provide valuable insights for weight management planning in PD, highlighting the importance of individualized approach that consider pre-diagnosis BMI.
Using heart rate monitoring to discover pain and discomfort in non-verbal persons with severe intellectual disability: Caregivers’ experiences
Authors: Boysen Elin Sundby , Øderud Tone , Strisland Frode , Kildal Emilie Smith-Meyer , Dahl Inger-Lise , Hassel Bjørnar , Morland Cecilie
Published: September 2024

BACKGROUND

Non-verbal persons with intellectual disabilities (ID) may suffer from pain or discomfort, but caregivers may not notice this because of the communication difficulties. Previously, we conducted a study in which professional caregivers used heart rate (HR) monitoring to identify situations that cause acute pain or distress in the everyday life of non-verbal persons with ID.

OBJECTIVE

To explore professional caregivers’ experience with using HR monitors to better understand non-verbal persons with ID.

METHODS

Fifteen professional caregivers and 30 final-year students of social education were recruited as informants based on their experience with HR monitoring in non-verbal persons. The informants were interviewed, and they responded to a questionnaire with open-ended questions. The qualitative data were analysed thematically.

RESULTS

Caregivers reported that HR monitoring provided information about acute pain, acute or prolonged distress, occurrence of epileptic seizures, and the non-verbal persons’ preferences and dislikes. HR data had to be interpreted contextually to be meaningful. Some informants found HR monitoring time-consuming or the interpretation of HR data challenging due to multiple possible causes of increased HR.

CONCLUSIONS

Caregivers experience HR monitoring as a potentially important source of information that may help them better understand non-verbal persons with ID.
Measures to manage cyberspace in Ho Chi Minh City in the current international integration
Authors:   Ho Chi Minh University of Technology, VNUHCM, Nguyen Ty Huu Ky
Published: September 2024

Ho Chi Minh City is a locality with a leading strategic role and position in the country in all fields of politics, economy, culture, society, defense and security, foreign affairs, international cooperation, etc. This is also the leading city in the country in terms of the rate of people using internet. With the continuous development of internet services, cyberspace in general, and social networking sites in particular bring many benefits to users because of the fast and diverse information speed, rich content, etc. If exploited and used reasonably, it can bring significant benefits in learning, working, social activities, and daily life for everyone. However, along with the positive aspects that cyberspace offers, there have been many issues related to security, personal privacy, scams, online environment safety, and harmful information against the government, etc. These are the major issues and challenges for state management agencies in providing a flexible cyberspace management matching the city’s characteristics in order to prevent bad and malicious news and create a safe and healthy one, contributing to the goal of fundamental and comprehensive innovation for the operations of the digital government apparatus and digital enterprises towards the civilization of a digital society.
The carbon market and the organization and development of the current carbon market
Authors:   Ho Chi Minh City University of Technology, VNU-HCM, Cao Quan Hong , Le Hong Nhat ,   Ho Chi Minh University of Law
Published: September 2024

The Law on Environmental Protection 2020, effective from January 1st, 2022, has specified the development of the carbon credit market in the law, which is considered an effective economic tool. The construction and development of carbon market regulations are an irreversible trend in the general development of the international community. However, the problem is the formation of a transparent, harmonized domestic and international carbon market, without putting too much pressure on businesses, making the most of all the resources that Vietnam has, while ensuring that the development of the carbon market must be associated with response to climate change, towards a low-carbon economy, which requires Vietnam to build a strict legal system throughout a stable process and effectively enforce it. In the process of building a low-carbon economy, from international commitments, Vietnam has affirmed that through the available resources, Vietnam will reduce greenhouse gas emissions while clearly identifying key areas where we can focus on reducing emissions. Therefore, in order to reduce greenhouse gas emissions and develop the carbon market associated with the goal of climate change minimization, aiming to build a low-carbon economy, the domestic carbon market must be built based on a perfect mechanism that can be practically applied in the development trend of society. The article clarifies the issues related to the carbon market, the organization and implementation of the current carbon market, and at the same time, the authors study international experience to propose directions to improve the organization and development of the domestic carbon market.
Alberto Ladrón de Guevara Jiménez. Médico y humanista, maestro e historiador
Authors: Torres Salazar Hugo , Gutiérrez Gauna Salvador Alejandro , Luce Guzmán David , Villarruel Gascón Carlos , Ladrón de Guevara Cox Helen , González Trujillo Ma. de Lourdes , Ruiz Briseño Gabriela Guadalupe , Viveros Ríos Ortencia , Meléndez Vizcarra Dora , Meléndez Vizcarra Lorena , Vera Hernández Laura
Published: September 2024

Alberto Ladrón de Guevara fue humano en su carrera como médico y generoso en el oficio magisterial. Ejerció la medicina en Guadalajara, en instituciones como el Hospital Civil, el Seguro Social y el Sanatorio Guevara, y su labor con la comunidad latina fue muy significativa durante varios años en el Hospital de Chicago, Estados Unidos. Asimismo, en la Universidad de Guadalajara dejó un gran ejemplo en su trayectoria como director de la Facultad de Filosofía y Letras y como profesor. Enseñaba historia y educaba sobre cómo enseñar historia; impartía sus clases como pensaba, pensaba como investigaba y transmitía el conocimiento histórico con la curiosidad e imaginación de todo científico social. El doctor Ladrón de Guevara siempre llevó a cabo la práctica profesional de ambas actividades con excelencia y fundamento ético. Así lo demuestran los textos compilados en este libro, que desde distintos enfoques y con sólida documentación resaltan la figura de un destacado médico, entrañable maestro y jalisciense ejemplar.
KINERJA PEGAWAI: PERAN MOTIVASI DALAM PENGARUH KOMITMEN DAN LINGKUNGAN KERJA
Authors: Yudiningtyas Lutfi Agustina , Winarko Ruddy
Published: September 2024

The purpose of this study was to describe and analyze the influence of organizational commitment and work environment on employee performance through work motivation. This study was conducted at the Investment and One-Stop Integrated Service Office of Bojonegoro Regency with a population of 52 people, then the sample used was all members of the population using total sampling. Data were collected with a questionnaire and analyzed by Partial Least Square (PLS). The results of the study showed that performance and work environment were in good condition, and work environment were in high condition, Organizational commitment and work environment affect work motivation. Work environment has a direct impact on employee performance, while organizational commitment does not. Work motivation has a significant impact on employee performance, and both affect employee performance indirectly through work motivation.
INOVASI SEBAGAI MEDIATOR ANTARA KEPEMIMPINAN TRANSFORMASIONAL, SELF-EFFICACY, DAN KINERJA PEGAWAI
Authors: Juarini Nisa , Indrawati Mei
Published: September 2024

This study aims to describe the condition of performance, innovation, transformational leadership and work self-efficacy in the Bojonegoro Regency Transportation Agency. In addition, it is also to analyze the direct and indirect influence of leadership and work self-efficacy on performance through employee innovation. This study is classified as an Explanatory Research type with a quantitative approach. The population studied was all employees of the Bojonegoro Regency Transportation Agency, totaling 64 people. The research sample was determined as many as 64 people with the total sampling method. The data analysis technique used Path Analysis through the Partial Least Square (PLS) method. From the results of the analysis, it was concluded that transformational leadership, innovation and performance of employees of the Bojonegoro Regency Transportation Agency were in good condition, only employee self-efficacy was very good. Transformational leadership had a significant effect on employee innovation. Self-efficacy had a significant effect on employee innovation. Transformational leadership directly had a significant effect on employee performance. Self-efficacy did not have a significant effect on employee performance. Innovation had a significant effect on employee performance. Transformational leadership had a significant effect on performance through employee innovation. Self-efficacy had a significant effect on performance through employee innovation.
PERAN KOMUNIKASI DALAM KEPEMIMPINAN EFEKTIF PADA ORGANISASI MAHASISWA
Authors: Saleh Munandi , Heryadi Ahmad Irwan , Kambali Laraswati , Aspirani Anisa , Abdullah Abdullah
Published: September 2024

Penelitian mengenai peran komunikasi dalam kepemimpinan efektif telah banyak dilakukan oleh peneliti sebelumnya, akan tetapi masih jarang yang melakukan penelitian dengan lokus pada organisasi mahasiswa. Penelitian ini bertujuan untuk mengetahui dan menjelaskan peran komunikasi dalam kepemimpinan efektif pada organisasi mahasiswa UMMI. Deskriptif kuantitatif digunakan sebagai metode penelitian ini, sedangkan sebagai sampel yaitu perwakilan dari setiap organisasi mahasiswa dalam hal ini sekretaris dan anggota yang berjumlah 88 responden. Penyebaran kuesioner kepada responden dimanfaatkan dalam metode pengumpulan data riset ini. Hasil penelitian menjelaskan terdapat pengaruh positif signifikan komunikasi terhadap kepemimpinan efektif, dengan pengaruhnya sebesar 61,6%.
Su Kasîdesi (Şerh - Tahlil) Töreli Türk Edebiyâtı Çalışmaları-1, Ed. Abdülkadir Dağlar, Erhan Çapraz, Ertuğrul Karakuş
Authors: Usta Aynışah
Published: September 2024

Edebiyatımızda Hz. Peygamber'i konu edinen pek çok türden birisi na'ttır. İslâmî edebiyatta mühim bir yeri olan na't türünde yazılan pek çok manzûme arasında; Fuzûlî'nin Kasîde Der-Na't-ı Hazret-i Nebevî ismini verdiği, "su" redîfi dolayısıyla Su Kasîdesi adıyla anılan na'ti en meşhûr olanlarından biridir. Şâirin çeşitli mazmûn ve mefhûmları bir araya getirerek Hz. Peygamber aşkını ustalıkla işlediği bu manzûmeyi anlamaya ve açıklamaya yönelik birçok çalışma ortaya konmuştur. Değerlendirmemize konu olan, 2023 yılının sonlarında çıkan kitap da bu bağlamdaki son çalışmalardan biridir. 32 beyit hacmindeki manzûme için bu kitap, mukaddimeyle birlikte 33 kısımdır. Her kısımda bir beyti ekseriyetle birden fazla kalem şerh etmesi hasebiyle yazar sayısı açısından, mukaddimeyle birlikte 57 ayrı yazıdan oluşmaktadır. Metni doğru okuma, anlama ve açıklama gayesiyle 56 ayrı yazarın birleşerek ortaya koyduğu her bir şerh makalesi kendi içinde bir anlam dünyası olduğu gibi aynı zamanda birbirlerini tamamlayan parçalardır. Şâirin batnındaki manâyı aramadan önce şerhe konu olan metni şâirin söylediğine en yakın şekilde okunması gerektiğinden bu kitapta, Su Kasîdesi'nde var olan okunuşu ihtilaflı bazı kelimelerin okunma şekline ilâveten şârihlerin birikimlerine göre farklı anlam pencereleri aralanmaktadır. Farklı kalemlerin bir araya getirilmesiyle ortaya konan bu çalışma; bir metne getirilebilecek birden fazla yorumu toplu hâlde sunması yönüyle önceki çalışmalardan farklı bir kurguya sahip olup orijinal bir çalışma olarak sahada yerini almaktadır.
Research of stress-strain state of tank of small-size self-propelled sprayer
Authors: Babiii Andrii , Levytskyi Bohdan
Published: September 2024

For the developed design of a small-sized self-propelled sprayer, it is proposed to use a tank from which the working fluid is displaced under pressure in the power system of the spraying devices. For the safe operation of such a shell, a method of determining its stress-strain state has been developed. The main analytical dependences are based on the principles of the momentless theory of shells. The results of the calculations are the determined numerical values of stresses in the cylindrical part of the shell and its bottoms. Similar results were obtained when simulating the operation of such a tank using the SolidWorks2019 application program. A comparative analysis of the obtained numerical values of the studied quantities was performed. Recommendations have been made regarding the method of securing the tank to the sprayer frame.
Uncertainty's Effects Assessment and the Relevant Parameters on Soil-Pipe Interaction (SPI) System Responses Using Sobol Sensitivity Analysis
Authors: Bacha Chahrazad , Zoutat Meriem , Mekki Mohammed , Kazi Tani Nabil , Manuel Martins Neto dos Santos José
Published: September 2024

Buried pipes play a crucial role in the transportation and distribution of various substances, such as energy, fluids, and waste, influencing daily life and industrial activities. The interaction between soil and pipes significantly affects the distribution of forces and stresses in the soil-structure systems. This study focuses on the soil-pipe interaction (SPI) system, employing the simplified Winkler model to represent SPI. The uncertainty in soil and pipe parameters is a major source of variability in the response model. To address this, five semi-empirical models for computing the soil reaction modulus are analyzed. A global sensitivity analysis, specifically the Sobol method, is employed to quantify the effects of uncertain input parameters on soil reaction modulus and pipe flexural strains. Results indicate that soil parameters, particularly Young modulus, have the most substantial impact on the soil reaction modulus, while pipe parameters exhibit negligible effects. The sensitivity analysis provides insights into the influential factors and their interactions. Moreover, a probabilistic analysis is conducted to assess the variability of soil reaction modulus and pipe displacement, revealing differences among semi-empirical models and soil types. This study contributes to identifying key parameters affecting the SPI system, allowing for better-informed decision-making in pipeline design and management. The findings emphasize the importance of considering uncertainties in soil and pipe properties for accurate predictions of soil-pipe system behavior.
Associations Between Time to Administration of Antiseizure Medications and Short-Term Clinical Outcomes in Adults With Status Epilepticus
Authors: Kongsakorn Pongsakorn , Boongird Apisit
Published: September 2024

Background: Status epilepticus (SE) is a time-sensitive emergency that requires immediate treatment.
Objective: To analyze the associations between time to administration of antiseizure medications (ASM) and short-term clinical outcomes.
Methods: From January 1, 2014, to December 31, 2020, we performed a retrospective cohort study in adult patients who presented with SE. The primary objective was to analyze the association between the timing of ASM administration and mortality. The second and third objectives were to determine the relationship between the timing of ASM administration and length of hospital stay along with the modified Rankin Scale (mRS) at discharge, respectively.
Results: A total of 83 patients were enrolled. The mean age was 57 years. The mean length of hospital stay was 32 days. Benzodiazepine (BDZ) was prescribed as the first ASM in 79 (95.2%) patients. Levetiracetam was the second most frequently administered ASM (39, [47%]), followed by phenytoin (28 [33.7%]) and valproate (13 [15.7%]). Seventy-one patients (85.5%) had a seizure duration longer than t2 period. Therapy delay in SE and underdosing of ASM were noted in both alive and dead groups. Although the mortality rate was 20.5% and was highest in super-refractory SE (15 [88.2%]), we found no statistically significant difference between in-hospital mortality and timing of ASM administration. For secondary outcomes, including length of hospital stay and mRS, a statistically significant finding was only noted in the category of timing of seizure onset to the first ASM (P = .002 and P = .004, respectively).
Conclusions: This study showed no significant association between timing of ASM administration and in-hospital mortality. Prolonged duration of SE tends to be associated with increased mortality. SE guidelines were not followed in a substantial proportion of SE patients.
Morphine-Sparing Effect of Intermittent Versus Continuous Intravenous Infusion of Nefopam in Patients After Total Knee Arthroplasty: A Randomized Trial
Authors: Kachacheewa Woratanat , Wattanavijitkul Thitima , Wongsak Siwadol , Chalacheewa Theerawat
Published: September 2024

Background: Nefopam, a nonopioid analgesic, is recommended to improve pain control and minimize opioid-related side effects following total knee arthroplasty (TKA).
Objective: To compare cumulative morphine consumption between intermittent infusion (II) and continuous infusion (CI) of nefopam, combined with other multimodal analgesics, in TKA patients.
Methods: Fifty-eight patients were randomly assigned to receive either intermittent nefopam infusion (II group) (20 mg IV every 6 hours) or continuous infusion (CI group) (80 mg/day). The primary outcome was cumulative morphine consumption via patient-controlled analgesia, with secondary outcomes including pain scores every 4 hours and adverse drug reactions (ADRs).
Results: No significant difference was found in cumulative morphine consumption (median [range], 4 [0 -12] mg in II and 6 [0 - 18] mg in CI; P = .579) and the ADRs over 48 hours between groups. At 4 hours, the II group had significantly lower pain scores compared to the CI group (median [range], 0 [0 - 4] and 0 [0 - 8]; P = .008). However, by 24 and 36 hours, the CI group reported significantly lower pain scores compared to the II group; median (range), 0 (0 - 5) vs 2 (0 - 9) at 24 hours (P = .020)  and 0 (0 - 4) vs 2 (0 - 8) at 36 hours (P = .014).
Conclusions: Both intermittent and continuous nefopam infusion in primary TKA showed no significant difference in morphine-sparing or occurrence of ADRs within the 48-hour follow-up period. These findings suggest that both infusion methods are comparable in managing post-operative pain in TKA patients.
The Use Of Paperless Learning Media In Efl Classroom: A Qualitative Study About The Use Of Paperless Learning Media In English Subject At Stimikom Stella Maris Sumba
Authors: Emirensiana  Dappa Ege  , Dian Fransiska Ledi  , Derniati Malo  , Stanislaus Dedelis Adat  , Desti Mariana Taklal
Published: September 2024

English subject is one of the important subject at Stimikom Stella Maris. This international languawge is able to deliver students to international networks. To support the class, the media that usews in learning process not only modules but also paperless.This study reports the use of paperless learning media in STIMIKOM Stella Maris Sumba. In the informatics management study program, there are four classes. Each class has twenty students. The English course is given in the first and second of semester. This research uses a qualitative descriptive method with data collection techniques are interview, observation and documentation. The results of this study indicates that the paperless learning media in English subject class is beneficial to both the student and lecturer.
Keywords: paperless learning media, English Subject
BARRIERS OF BUILDING INFORMATION MODELLING (BIM) IMPLEMENTATION: CURRENT PERSPECTIVES OF CONSTRUCTION STAKEHOLDERS IN JOHOR, MALAYSIA
Authors: Roseli Faris Aiman , Abas Nor Haslinda , Ibrahim Nur Qamarina , Mohd Ta’at Nurul Hasanah
Published: September 2024

Building Information Modelling (BIM) is an innovative approach within the architectural, engineering, and construction (AEC) industry that has been globally adopted. Despite Malaysia’s construction industry experiencing substantial growth and technological advancements, a significant proportion of AEC firms remain uninterested in BIM due to anticipated challenges. This study aims to explore the hurdles hindering BIM implementation specifically within the Johor region of Malaysia’s AEC construction sector. Data were gathered through a survey and analyzed using the Average Index method. The findings highlight several key factors impeding BIM adoption, notably a lack of awareness regarding its benefits among stakeholders, inadequate standardization in government regulations, and the high costs associated with software licenses. Addressing these barriers is crucial for stakeholders to devise effective strategies for overcoming obstacles and fostering the adoption of BIM in construction practices.
EVALUATION OF PHYSICAL AND MINERALOGICAL PROPERTIES OF GRAPHITE-MODIFIED BITUMEN
Authors: Lawal Mamadu , Joseph Oyedepo Olugbenga , Omoniyi Olukanni Ebenezer , Jayejeje Omomomi Oladapo
Published: September 2024

This study aimed to investigate the impact of adding graphite on the physical and mineralogical properties of bitumen in asphalt mixtures, covering a graphite content ranging from 0% to 8%. A variety of tests were conducted to assess these effects, including measurements of softening point, flash and fire values, ductility point, Marshall stability, Marshall flow, and indirect tensile strength. Evaluations also encompassed assessments of particle size distribution through coefficients of uniformity (Cu) and gradation (Cc), aggregate strength via Aggregate Crushing Value (ACV) tests, and impact resistance with Aggregate Impact Value (AIV) tests. The results indicated a desirable well-graded particle size distribution in the soil sample, with Cu and Cc values of 4.5 and 0.5, respectively. The aggregate showed a satisfactory ACV of 28.91%, falling within the recommended range, and an AIV value of 19.84%, meeting road surfacing specifications. Adding graphite to bitumen increased the softening point, reaching a maximum value of 54.1°C at 8% graphite content. This addition also improved flash and fire values, with peak levels at the same graphite content. Furthermore, including graphite led to an enhanced ductility point, indicating improved flexibility. The graphite-modified asphalt concrete exhibited higher Marshall stability and flow, with optimum values of 18.09 kN and 3.80 mm, respectively, at 8% graphite content. The optimum indirect tensile strength of 986.20 kPa also occurred at 6% graphite content. XRD characterization confirmed the presence of various minerals in the unmodified bitumen, such as feldspars, pyroxenes, and quartz, which increased the specific surface area and reduced mechanical strength. In contrast, graphite-modified bitumen exhibited a modified structure with reduced specific surface area, and XRD patterns confirmed the presence of graphite, with a carbon content exceeding 85%. The study strongly recommends incorporating 6% graphite into asphalt mixtures, as this measure significantly enhances their performance and durability.
INVESTIGATION OF HOT MIX ASPHALT PROPERTIES WITH INCORPORATION OF CRUMB TYRE AND POLYCARBONATE
Authors: Joseph Oyedepo Olugbenga , Adekunle Adewuyi Abiodun , Jayejeje Omomomi Oladapo
Published: September 2024

Asphalt, a crucial material in construction, demands constant improvement to meet evolving infrastructure requirements. This research addressed the need for enhancing asphalt properties by incorporating crumb tyre, crumb polycarbonate, and their combined formulation as additives. The objective was to modify bitumen properties for optimized asphalt production, specifically focusing on strength characteristics. The study employed a comprehensive methodology to assess the impact of these additives on bitumen. It examined their influence on penetration, ductility, softening point, viscosity, and thermal stability, particularly the flash and fire points. Various proportions of additives were investigated, seeking the most effective composition. The results of this research unveil promising outcomes. The additives exerted a stiffening effect on bitumen, altering its molecular structure and intermolecular interactions. Consequently, penetration values decreased, indicating enhanced stiffness. Moreover, ductility significantly increased, suggesting improved resistance to deformation. Furthermore, the softening point of bitumen rose, indicating heightened resistance to softening at elevated temperatures. The viscosity of bitumen decreased upon additive introduction, simplifying mixing with aggregates during asphalt production. The additives also elevated the flash and fire points, signifying enhanced thermal stability. Based on these findings, the recommended mix consists of 10% crumb tyre, 10% crumb polycarbonate, and 10% of both additives combined. This composition outperforms other proportions, presenting a viable solution to enhance asphalt properties for a wide range of road applications.
INVESTIGATING THE ROLE OF BUILDING INFORMATION MODELING IN RISK MANAGEMENT OF CONSTRUCTION PROJECTS
Authors: Abdelalim Ahmed Mohamed , Elnaggar Ahmed M. Elshafie
Published: September 2024

Risk management is a crucial component of building projects that aids in achieving objectives and reducing risks. Risks associated with management, such as coordinating between disciplines and communicating with stakeholders at various project phases, are common in construction projects. This study set out to get a deeper understanding of the ways in which risk management planning methods for building projects might be developed using Building Information Modeling (BIM). A survey instrument was created and dispersed among specialists in the building sector. The questionnaire’s results showed that, despite certain challenges like inadequate training and improper utilization in construction contracts, building information modeling is useful in risk management planning procedures. These challenges could make it impossible for building information modeling to be used in building projects. The majority of respondents did, however, agree that BIM is a useful tool for managing project risk in construction. The study concludes with a conceptual framework for using BIM in risk management procedures across several project life cycles.
Implementation of virtual reality to enhance spatial abilities: a study on aspects, effects, and differences in participants' initial ability levels
Authors: Pahmi Samsul , Vrapi Asllan , Supriyadi Edi
Published: September 2024

This research is important because the development of Virtual Reality (VR) technology has shown significant potential in enhancing spatial abilities, which are crucial aspects of education and training across various fields. This study aims to identify and evaluate the extent to which VR can enhance spatial abilities and determine the factors that influence the adoption of VR in educational contexts. The specific target is to identify at least three main factors affecting the effectiveness of VR in improving spatial abilities and to evaluate its impact on differences in students' initial abilities. The research method used is a Systematic Literature Review (SLR), which involves identifying, evaluating, and interpreting all relevant research that answers specific research questions. Data were collected from three major databases: Scopus, ScienceDirect, and Sage Journal, covering 2013 to 2022. This study focuses on considerations for using VR, its impact on differences in initial spatial abilities, and the various aspects of spatial abilities affected by VR intervention. The results from the 26 studies reviewed indicate that the use of VR technology in learning can enhance spatial abilities, with the most studied aspect being mental rotation. Additionally, VR has a greater impact on participants with a low spatial ability background. From an affective aspect, the use of VR significantly influences participants' motivation and interest, attributed to the realistic and interactive effects perceived. The implications of this research provide important contributions for researchers and educational practitioners to develop more effective interventions in enhancing spatial abilities in the future.
Publication trends on proportional reasoning research: A bibliometric analysis using Scopus database
Authors: Sugiarni Rani , Abdullah Khairul Hafezad
Published: September 2024

Proportional reasoning ability is an important ability for students to understand mathematical concepts. Much research has been conducted on this capability, but it is necessary to map existing research to provide a clearer picture of future research topics. This research aims to provide a bibliometric overview of trends in the use of proportional reasoning skills in mathematics teaching research. The method in this research is bibliometric analysis, which aims to analyze and classify bibliographic material by presenting a representative summary of literature in the Scopus database. The search was carried out using the keyword "proportional reasoning" in the search menu in the Scopus.com database. ScientoPy software analyzes the author's name, number of document citations, document title, publication year, document source, publisher, and document type Research trends in proportional reasoning show a significant increase, with 356 publications in Scopus, peaking at 32 in 2023. Major contributors include the United States, Turkey, and Spain, with recent studies focusing on "teacher knowledge." Influential works by Liberali et al., Atkinson et al., and Tobin & Capie address numeracy, multimedia learning, and logical thinking, respectively. These findings suggest that improving teacher knowledge and using effective multimedia tools could enhance instruction and research in proportional reasoning. Future research should explore innovative teaching strategies and technologies to further advance proportional reasoning ability.
SciJava Ops: an improved algorithms framework for Fiji and beyond
Authors: Selzer Gabriel J. , Rueden Curtis T. , Hiner Mark C. , Evans Edward L. , Kolb David , Wiedenmann Marcel , Birkhold Christian , Buchholz Tim-Oliver , Helfrich Stefan , Northan Brian , Walter Alison , Schindelin Johannes , Pietzsch Tobias , Saalfeld Stephan , Berthold Michael R. , Eliceiri Kevin W.
Published: September 2024

Decades of iteration on scientific imaging hardware and software has yielded an explosion in not only the size, complexity, and heterogeneity of image datasets but also in the tooling used to analyze this data. This wealth of image analysis tools, spanning different programming languages, frameworks, and data structures, is itself a problem for data analysts who must adapt to new technologies and integrate established routines to solve increasingly complex problems. While many “bridge” layers exist to unify pairs of popular tools, there exists a need for a general solution to unify new and existing toolkits. The SciJava Ops library presented here addresses this need through two novel principles. Algorithm implementations are declared as plugins called Ops, providing a uniform interface regardless of the toolkit they came from. Users express their needs declaratively to the Op environment, which can then find and adapt available Ops on demand. By using these principles instead of direct function calls, users can write streamlined workflows while avoiding the translation boilerplate of bridge layers. Developers can easily extend SciJava Ops to introduce new libraries and more efficient, specialized algorithm implementations, even immediately benefitting existing workflows. We provide several use cases showing both user and developer benefits, as well as benchmarking data to quantify the negligible impact on overall analysis performance. We have initially deployed SciJava Ops on the Fiji platform, however it would be suitable for integration with additional analysis platforms in the future.