bluuebunny/crossref_metadata_2025 huggingface dataset:
A case of catecholamine crisis induced by iatrogenic glucocorticoids: case report
Authors: Zhang Qingqing , wei Xue , Zheng Jing , Li Boliang , Xu Bangkui , Lu Yu , Yang Shufang , Wu Yucheng
Published: December 2023

Background: Pheochromocytoma is a rare neuroendocrine tumor originating from chromaffin cells in the adrenal medulla, and is a rare type of secondary hypertension. It mainly synthesizes and secretes excessive catecholamines, causing a series of clinical symptoms, such as headache, sweating, palpitations, and may be life-threatening in severe cases. In the current case report, we describe a rare case of a clinically manifesting pheochromocytoma with which landed in pheochromocytoma crisis.
Case presentation: The authors describe a rare case of a clinically manifesting pheochromocytoma with which landed in pheochromocytoma. A 19-year-old female was admitted with headache, recurrent nausea and vomiting, and fever. The patient's levels of troponin I and BNP increased after using glucocorticoids. And the patient continued to be treated with glucocorticoids due to misdiagnosis as myocarditis. Computerized tomography exposed a soft tissue density mass at the left adrenal gland.
Further evaluations revealed high levels of plasma catecholamines and 24-hour urine catecholamines and their metabolites. The patient was clinically diagnosed with pheochromocytoma and discontinued glucocorticoids. RET Cys634Arg mutation was found in this case. After 3 months of preparation, the patient underwent surgical. The patient was discharged from hospital without further medication. The patient was followed-up regularly after surgery and did not experience any of the above symptoms.
Conclusion: Glucocorticoids can induce crisis in pheochromocytoma. Therefore, before starting therapeutic glucocorticoids, any clinical signs or symptoms of a potential pheochromocytoma or adrenal accidental tumors should prompt reliable biochemical testing to rule out a pheochromocytoma.
A CFRP Passenger Floor Stanchion Underwent Dynamic Buckling Structural Testing
Authors: Mauro G. Di , Guida M. , Ricci F. , Maio L.
Published: December 2023

The work focuses on the study of the structural behaviour of a composite floor beam in the cargo area of a commercial aircraft subjected to static and dynamic loads (typical of hard or crash landing). Experimental tests have been performed in the laboratories of the Dept. of Industrial Engineering (UniNA) jointly with the development of numerical models suitable to correctly simulate the phenomenon through the LS-DYNA software. The definition of a robust numerical model allowed to evaluate the possibility of buckling triggering. The test article was equipped with potting supports on both ends of the tested beam, filling the pots with epoxy resin toughened with glass fiber nanoparticles. This allowed to uniformly load the beam ends in compression and to carry out the tests loading the specimen statically and dynamically, to observe the differences in the behaviour of the beam under two different types of applied load. The result obtained through the comparison between the numerical model and the experimental test was that the dynamic buckling was triggered by a quantitatively smaller load than in the static case. Furthermore, it has been observed that the experimental compressive displacement to trigger the dynamic buckling instability was greater than the displacement observed in the static case.
Efficacy and safety of percutaneous balloon compression for bilateral trigeminal neuralgia： a retrospective study
Authors: Wang Yinzhan , Guo Wenchang , Du Yihui , Li Yang , Shi Haowei , Qian Tao
Published: December 2023

Background Percutaneous balloon compression（PBC）of the Gasserian ganglion is steadily gaining traction within the trigeminal neuralgia（TN）community. Bilateral trigeminal neuralgia（BTN） is a rare condition, and its treatment remains challenging. As far as we know, there are currently no research reports on the treatment outcomes of PBC for BTN.The purpose of this study is to meticulously evaluate the efficacy and safety of PBC for BTN in our medical institution.
Methods In this retrospective study, we collected and analyzed the medical records of all patients with BTN who underwent the PBC procedure at the Department of Neurosurgery at Hebei General Hospital from July 2017 to July 2023. After undergoing PBC therapy, all patients were promptly assessed for treatment efficacy based on the modified Barrow Neurological Institute (BNI) pain intensity grading scale.
Results All 37 patients with BTN experienced significant pain relief (BNI I-IIIb) immediately following unilateral PBC treatment. Among these patients, 25 reported relief from pain on the non-operative side, which was effectively managed with medication. Out of the 12 patients who did not experience improvement in contralateral symptoms, 11 received contralateral PBC. Out of the 48 treated sides, 47 sides (97.9%) achieved excellent pain control following a single PBC procedure. The follow-up times ranged from 2 to 62 months.The cumulative survival after PBC was 100%, 90.2%, and 80.2% within 1, 3, and 5 years, respectively.Three recurrent patients underwent repeated unilateral PBC, and all of them maintained excellent pain control postoperatively. At the last follow-up, satisfaction was at 91.7% (measured using the Likert scale), with no severe complications occurring.
Conclusions The results indicate that PBC is an effective and relatively safe method for treating BTN, offering a valuable option for pain control in these rare cases of TN.
Predictive factors of pathological lateral pelvic lymph node metastasis in patients with selective laparoscopic lateral lymph node dissection for rectal cancer:A retrospective Study
Authors: Yang Yugang , Xue Xiajuan , Shen Huiqun , Xu Xiaozhen , Cai Mingzhi , Guo Yincong
Published: December 2023

Background:In recent years, selective lateral lymph node dissection（LLND） has been recognized by more and more surgeons.However, the indication for this procedure remains unclear.
Purpose: We aimed to identify the predictive factors for pathological lateral pelvic lymph nodes metastasis(LPNM) and the indications for lateral pelvic lymph node dissection.
Methods: This study involved 55 patients with locally advanced rectal cancer and clinically suspected lateral pelvic lymph nodes(LPN) metastasis who underwent total mesorectal excision（TME）with LLND between December 2019 and October 2023. According to pathological findings, they were divided into negative LPN (n=35) and positive LPN(n=20) groups. Primary endpoints were overall pathologic positive rate and risk factors of pathological LPNM.
Results: Among 55 patients, 20 (36.4%) had pathologically confirmed lateral pelvic lymph node metastasis. Initial short-axis diameter of LPN (≥7mm,p=0.003), imagie risk factors (≥3,p=0.008), LLND time (heterochronism,p=0.014),distant metastasis(yes,p=0.005) and p-N stage(N2,p＜0.001) were significantly associated with pathological LPNM. Initial short-axis diameter of LPN (p=0.012,OR 12.732,95%CI 1.768-91.699) and p-N stage(p=0.010,OR 13.650,95%CI 2.658-95.380) were independent risk factors for pathological LPNM in multivariable analysis furtherly.
Conclusion: Initial short-axis diameter of LPN and p-N stage were significant predictors of lateral pelvic lymph node metastasis. This study recommended that initial short-axis diameter of LPN ≥7 mm as a Cut-off value for selective LLND.
Calpeptin mitigates ventriculomegaly and microvascular impairment in a novel LPS- dependent mouse model of acquired hydrocephalus
Authors: Ledbetter Jenna , Lee Seunghyun , Sato Sora , Jison Gio , Romero Bianca , Shahriari Amirhossein , Padilla Alejandra , Torres Evelyn , Tran Celine , Muhonen Michael , Castañeyra-Ruiz Leandro
Published: December 2023

Hydrocephalus, characterized by ventricular distension due to impaired cerebrospinal fluid (CSF) pathways, is a multifactorial condition with perinatal infection as a predominant global cause. Over three decades, alterations in periventricular cell junctions, especially cadherins, have been linked to pediatric hydrocephalus pathogenesis. We propose that the Toll-like receptor (TLR)–calpain (calcium-dependent proteinase) pathway induces cadherin cleavage, playing a central role in initiating vascular impairment associated with vascular permeability and ventriculomegaly—hallmark events in acquired hydrocephalus (AH).
In this manuscript, perinatal C57BL/6 mice and endothelial cell cultures were exposed to lipopolysaccharide (LPS) toxin, a gram-negative bacteria component, modeled post-infectious hydrocephalus. For treatment, calpain inhibitor (calpeptin) and TLR-4 receptor inhibitor were employed in cell cultures, with calpeptin used in mice. Magnetic resonance imaging (MRI) quantified ventricular volume, and immunofluorescence and DiI assessed microvascular integrity. Additionally, endothelial permeability was evaluated using a transwell system.
Results showed that in vitro LPS induced increased endothelial permeability associated with calpain-dependent cleavage of VE-cadherin. In vivo, intraventricular LPS-induced ventriculomegaly linked to microvascular impairments dorsally to the ventricles (p<0.05). In vitro, TLR and calpain inhibition exhibited similar vascular permeability and VE-cadherin cleavage after LPS exposure compared to the control. In vivo, calpain inhibition prevented or attenuated ventriculomegaly and significantly improved survival after LPS injection (p<0.05).
This research offers a comprehensive analysis from in vitro experiments on C57BL/6 mice primary brain microvascular endothelial cells to in vivo mouse models, highlighting the pivotal role of the TLR4-Calpain pathway, VE-cadherin cleavage, and vascular impairment in acquired hydrocephalus pathogenesis. The findings emphasize the potential of calpain inhibition in preventing the physiopathology associated with LPS exposure.
Targeting mTOR and Survivin Concurrently Potentiates Radiation Therapy in Renal Cell Carcinoma by Suppressing DNA Damage Repair and Amplifying Mitotic Catastrophe
Authors: Rachamala Hari K. , Madamsetty Vijay S. , Angom Ramcharan S. , Nakka Naga M. , Dutta Shamit Kumar , Wang Enfeng , Mukhopadhyay Debabrata , Pal Krishnendu
Published: December 2023

Background
Renal cell carcinoma (RCC) was historically considered to be less responsive to radiation therapy (RT) compared to other cancer indications. However, advancements in precision high-dose radiation delivery through single-fraction and multi-fraction stereotactic ablative radiotherapy (SABR) have led to better outcomes and reduced treatment-related toxicities, sparking renewed interest in using RT to treat RCC. Moreover, numerous studies have revealed that certain therapeutic agents including chemotherapies can increase the sensitivity of tumors to RT, leading to a growing interest in combining these treatments. Here, we developed a rational combination of two radiosensitizers in a tumor-targeted liposomal formulation for augmenting RT in RCC. The objective of this study is to assess the efficacy of a tumor-targeted liposomal formulation combining the mTOR inhibitor everolimus (E) with the survivin inhibitor YM155 (Y) in enhancing the sensitivity of RCC tumors to radiation.
Experimental Design:
We slightly modified our previously published tumor-targeted liposomal formulation to develop a rational combination of E and Y in a single liposomal formulation (EY-L) and assessed its efficacy in RCC cell lines in vitro and in RCC tumors in vivo. We further investigated how well EY-L sensitizes RCC cell lines and tumors toward radiation and explored the underlying mechanism of radiosensitization.
Results
EY-L outperformed the corresponding single drug-loaded formulations E-L and Y-L in terms of containing primary tumor growth and improving survival in an immunocompetent syngeneic mouse model of RCC. EY-L also exhibited significantly higher sensitization of RCC cells towards radiation in vitro than E-L and Y-L. Additionally, EY-L sensitized RCC tumors towards radiation therapy in xenograft and murine RCC models. EY-L mediated induction of mitotic catastrophe via downregulation of multiple cell cycle checkpoints and DNA damage repair pathways could be responsible for the augmentation of radiation therapy.
Conclusion
Taken together, our study demonstrated the efficacy of a strategic combination therapy in sensitizing RCC to radiation therapy via inhibition of DNA damage repair and a substantial increase in mitotic catastrophe. This combination therapy may find its use in the augmentation of radiation therapy during the treatment of RCC patients.
The changing role of family as provider of intergenerational support during COVID- 19: a longitudinal study into the mental health consequences for older Europeans
Authors: Herreweghe Lore Van , Lancker Wim Van
Published: December 2023

Intergenerational support is an important determinant of mental health for all family members involved. Due to limited access to formal care, the role of the family as provider of support became more prominent during the COVID-19 pandemic. To date, it remains unclear how intergenerational support from adult children to older parents was affected during the pandemic and whether this had consequences for the mental health of the parent generation. Using data from the Survey of Health, Ageing and Retirement (SHARE) Corona Surveys, we explore whether changes in support going from non-coresident adult children to their parents are associated with parents’ changes in depressive feelings. Additionally, we test whether the pandemic context and stringency of public health measures affected this relationship. Families responded to the increased needs of elderly parents by providing more informal support. These changes in intergenerational support, however, were related to increased depressive feelings for the older parents. Furthermore, both the strictness of public health measures and the concurrent epidemiological situation affected this relationship. We conclude that the family is an essential source of late-life well-being. But, stressful life events such as public health crises put pressure on these intergenerational relations with potential adverse mental health outcomes. Future policies should take into account the ambivalent nature of intergenerational relationships.
Endovascular repair in patients with aortic dissection and aortic aneurysm: A retrospective cohort study.
Authors: Alvarez-Covarrubias Hector A. , Uribe-González Jhonathan , Montoya-Guerrero Silvestre A. , Saturno-Chiu Guillermo , Estrada-Gallegos Joel
Published: December 2023

Background
Therapeutic options in patients with aortic diseases include medical treatment, surgical and percutaneous intervention. The latter has been proved to be safe in patients with aortic aneurysm (AA) and aortic dissection (AD), but still represents challenging and with significant mortality rates. For these reasons, we aimed to compare procedural and in-hospital complications in patients with AA and AD treated with transfemoral transcatheter endovascular aortic repair (EVAR).
Methods
Patients treated using transfemoral EVAR from 2012 to 2017 at the Hospital de Cardiología, Centro Médico Nacional Siglo XXI, Mexico City with complete computed tomography (CT) and diagnostic of AA and AD were included. Procedural and in-hospital related complications were compared among patients treated due to AA and AD. Endpoints of the study were in-hospital and thirty days all-cause mortality and any cause of readmission.
Results
A total of 38 patients with high quality CT were included in the analysis. From them, 25 had AA and 13 AD. Mean age was 64 ± 14 yeas, 23.7% were females. Urgent treatment was required in 31.6%, the number of prosthesis used was 2.13 [1, 5] per patients. No in-hospital mortality was observed. Type 1a endoleak was similar in both groups (AA 8% vs. AD 15.4%, p = 0.59). Conversion to surgery was needed only in one patient (AA 4% vs AD 0%, p > 0.99). No difference was observed regarding endovascular reintervention (16% vs. 15.4%, p > 0.99), graft thrombosis (12% vs. 0%, p = 0.53), spinal cord injury (0% vs. 15.4%, p = 0.11) or vascular complication (8% vs. 15.4%, p = 0.59%) between AA and AD respectively. No 30-days mortality was observed.
Conclusions
EVAR represents a safe procedure in patients presenting with AA or AD, with no in-hospital or 30 days mortality rate and very low reintervention rate.
Indirubin in Vitro Apoptotic Effect Towards Chronic Lymphocytic Leukaemia (CLL) Lineage
Authors: Jafarinejad Habib , Yarmohammadi Reyhaneh , Piccin Andrea , Aghaie Afsaneh , Rostami Tahereh , Faranoush Mohammad , Hemmati Maral , nikroo Nikta Dadkhah , Moghadam Bijan Sedighi , Kokhaie Parviz
Published: December 2023

Chronic lymphocytic leukemia (CLL) is a chronic condition that usually affects elderly people. The etiology is unknown, however the current hypothesis is that over time the haematopoietic stem cells may acquire mutations that will lead to irregularity in apoptotic mechanism (e.g. BCL2 mutation). Dangui Luhui Wan consist in mix of 11 herbs used by the Chinese Medicine. This herbal compound has proven to have antitumoral activities on various types of cancer cells. A derivate from Dangui Luhui Wan is indirubin-3'-monoxime (I3M). This substance act as selective inhibitor of cyclin-dependent kinases (CDKs) and can induce cell apoptosis. The aim of this study was to test the efficacy of I3M against CLL cells in vitro. We evaluated the expression of apoptotic proteins Bcl2/Bax and CDK1/2 using real-time PCR. Peripheral mononuclear cells (PBMCs) obtained from 14 patients were treated with 20 μM of I3M for 48hrs. After treatment a reduced Bcl-2 expression was noticed. No significant changes were seen for Bax. However, an increased Bax/Bcl-2 ratio was documented, suggesting that mitochondrial pathway is involved in I3M apoptotic-mechanism of action. Interestingly, I3M could inhibit the expression of CDK2, while it does not affect the expression of CDK1. These results indicated that I3M exerts anti-tumor effects through induction apoptosis and inhibition of CDK2. Further studies are now needed to clarify the exact mechanism of action of I3M in CLL and possibly in other tumoral cell lines.
Interaction between alcohol drinking status and hay fever on atopic dermatitis: NHANES 2005–2006
Authors: Ding Qike , lin Lihong , Li Xiaoting , jing Wenjuan , xie Xiaoping , chen Xinyu , chen Jiadong , Lu Tao
Published: December 2023

Background
hay fever may increase the risk of atopic dermatitis. However, few studies have investigated the joint effects of hay fever and alcohol drinking status on atopic dermatitis. Therefore, we aimed to explore the association between hay fever, atopic dermatitis, and alcohol drinking status.
Methods
4754 participants aged over 20 years from the National Health and Nutrition Examination Survey (NHANES) in 2005–2006 were involved in the study. Hay fever was defined by self-reported medical diagnosis, atopic dermatitis status was assessed by the question “Has a doctor or other health professional ever told you that you have eczema”, and alcohol drinking status was determined by the survey question, “In any 1 year, have you had at least 12 drinks of any type of alcoholic beverage?” Logistic regression, and stratified analysis of sub-groups were used in this study.
Results
hay fever was risk factor for atopic dermatitis. There was an interaction between hay fever and alcohol drinking status (P for interaction = 0.01). Hay fever was associated with increased risk of atopic dermatitis among the population who were alcohol non-drinkers. Compared with the population who were alcohol drinkers and without hay fever, the OR of atopic dermatitis was 3.71 (1.74, 7.90) for the population who were alcohol non-drinkers and with hay fever.
Conclusions
There was a positive interaction between hay fever and alcohol drinking status on atopic dermatitis. Alcohol may attenuate the detrimental impacts of hay fever on atopic dermatitis.
Neoadjuvant chemoradiotherapy is associated to higher postoperative complications and inferior long-term oncological survival outcomes in patients with proximal rectal cancers when compared with upfront surgery
Authors: Aliyev Vusal , Shadmanov Niyaz , Piozzi Guglielmo Niccolò , Bakır Barıs , Goksel Suha , Asoglu Oktar
Published: December 2023

Background
The role of preoperative chemoradiotherapy (CRT) in the management of proximal rectal cancer (PRC) is still debated. The purpose of this study was to compare perioperative and long-term oncological outcomes between PRC patients undergoing CRT + surgery and upfront surgery.
Methods
A total of 157 patients were retrospectively included in this study (131 treated with upfront surgery and 26 with CRT). CRT and upfront surgery groups were compared in terms of perioperative and long-term oncological outcomes.
Results
CRT group of patients was associated with higher rate of overall postoperative complications (42.3% vs. 18.3%, p < 0.05) and class III-IV complications (15.4% vs. 8.4%, p < 0.05). The 3 and 5-years overall survival (OS) rates for upfront surgery and CRT group were: 96.1%, 91.5% and 95.8%, 71.7% (p < 0.05), respectively. The 3 and 5-years disease-free survival (DFS) rates for upfront surgery and CRT were: 92.4%, 86.8% and 90.6%, 68.6% (p < 0.05), respectively.
Conclusion
The omission of CRT in patients with PRC did not impair the perioperative and long-term oncological outcomes. CRT is associated to higher complications rates and severity and to worst OS and DFS.
Comparative study on the application of tarsal tunnel block and spinal anesthesia in open osteotomy of hallux valgus
Authors: jia hong , Chen Yong-Feng , Wang Hua-Yi , sun qiang , wang yuan-rui , Zhang da
Published: December 2023

Background
Hallux valgus is a common and frequently occurring forefoot disease. Surgical treatment is often required for moderate to severe cases, and the choice of anesthesia during surgery significantly impacts postoperative functional recovery. This study aims to explore a more suitable anesthesia method for open hallux valgus surgery.
Methods
A total of 90 patients with hallux valgus admitted to the hospital from November 2016 to November 2020 were randomly divided into two groups: the tarsal tunnel block group and the spinal anesthesia group. Open osteotomy and internal fixation were performed on the first metatarsal and proximal phalanges using the anterolateral approach. Various observation indexes were set, and relevant data, including anesthesia operation time, anesthesia onset time, operation time, anesthesia duration, changes in vital signs during operation, fasting time, anesthesia complications, wound complications, hospitalization expenses, etc., were recorded. The VAS pain score questionnaire was filled out before and after the surgery, and a follow-up was conducted.
Results
The tarsal tunnel block group exhibited shorter operation and onset times of anesthesia, as well as longer duration of anesthesia effect. Moreover, fasting water was not required before or after the surgery, anesthesia complications were fewer, and patient activities were not affected. The difference between the two groups was statistically significant (P < 0.05).
Conclusion
The application of tarsal tunnel anesthesia instead of traditional spinal anesthesia in open hallux valgus surgery has a broader application range and can fully meet the clinical needs of open hallux valgus surgery.
Opportunistic screening for COPD among socially marginalized patients
Authors: Brünés Nina , Lindstroem Mette Bendtz , Ulrik Charlotte Suppli , Andersen Ove , Lisby Marianne , Godtfredsen Nina Skavlan , Hansen Tina Leth , Pisinger Charlotta , Graven Vibeke , Marsaa Kristoffer , Thomsen Laura Hohwü
Published: December 2023

Background
Chronic obstructive pulmonary disease (COPD) is a common disease associated with premature death. Tobacco exposure is the main risk factor, but lower socioeconomic status, early life insults, and occupational exposures are also among the risk factors. Smoking cessation and early detection of COPD are crucial in order to improve outcomes. Socially marginalized people, facing homelessness, substance use disorder, and mental illness, are likely to have a higher risk of developing COPD, and, furthermore, experience barriers to healthcare access and consequently poorer outcomes.
Objective
This study aims to assess COPD prevalence and impact of opportunistic screening among hospitalized patients who are in contact with hospital social nurses. These patients constitute a group of patients with a high prevalence of psychiatric and somatic diseases, substance use, low life expectancy, and are socially marginalized.
Methods
The present prospective longitudinal study includes a clinical examination at baseline. Participants will have spirometry done and participate in interviews regarding risk factors, socioeconomic conditions, and respiratory symptoms. The 5-year follow-up assessment incorporates data from baseline and register data over the five years, including information on morbidity, use of COPD medication, hospital contacts, mortality, and socioeconomic factors.
Anticipated results
Referral for further diagnostic work-up and management after the screening, including COPD treatment and smoking cessation support, is expected to improve survival rates. As the study is still enrolling patients there are no preliminary findings.
Trial Registration
The study is registered at ClinicalTrials.gov, NCT04754308 with study status: “enrolling”
Effect of lipid extraction and room temperature transportation of bovine oocytes determined by MRM profiling
Authors: de Lima Camila Bruna , Milazzotto Marcella Pecora , Vireque Alessandra Aparecida , Joaquim Daniel Carlino , Sobreira Tiago Jose Paschoal , Ferreira Christina Ramires
Published: December 2023

Lipids play many important physiological roles in mammalian reproduction, being essential for the acquisition of oocyte competence and post-fertilization embryonic development. Lipid profiling in samples of minute size, such as oocytes, is challenging but has been achieved by mass spectrometry technologies such as multiple reaction monitoring (MRM) profiling. With the goals of further simplifying sample workflow and investigating the influence of pre-analytical conditions, we have evaluated how different extraction methods and transportation of lipid extracts in vacuum and at room temperature impacted the lipid profile of bovine oocytes. Using a comprehensive method, 316 MRMs associated with lipids of 10 different classes were screened in oocyte lipid extracts prepared by 2 extraction methods (one-step methanol addition or Bligh and Dyer) and transporting them in dry ice or at room temperature inside vacuum packages. No changes in the multivariate analysis (PCA) were noticeable due to transportation temperature, while lipid profiles were more affected by the lipid extraction protocol. Sample extraction using pure methanol favored the detection of phospholipids uniformly, while Bligh and Dyer favored the detection of neutral intracellular lipids. Triacylglycerol lipids and free fatty acids yielded decreased abundances when samples were transported at room temperature. We conclude that if samples are submitted to the same lipid extraction protocol and same transportation batch at room temperature coupled with vacuum conditions it is possible to analyze lipid extracts of bovine oocytes and still obtain informative lipid profiling results.
CORRELATION ASSESSMENT OF THE PARAMETERS OF DENTAL STATUS IN CHILDREN WHO PERMANENTLY LIVE IN DIFFERENT GEOGRAPHICAL ZONES OF THE TRANSCARPATHIAN REGION
Authors: Klitynska Oksana , Shetelya Volodymyr , Layosh Nataliya , Zorivchak Tetiana , Stishkovskyy Andriy , Kruchak Roksolana
Published: December 2023

The aim of the study. To evaluate the dental status of children with different degrees of caries activity who constantly live in conditions of biogeochemical deficiency of fluorine and iodine and to determine the correlation dependence of indicators.
Materials and methods. An examination of 251 children aged 5 to 11 years (129 girls – 51.4% and 122 boys – 48.6%), residents of the mountain and lowland zones of Zakarpattia region, was conducted. The level of hygiene was assessed with the help of the Fedorov–Volodkina hygienic index, and the caries resistance of tooth enamel was determined using the DIAGNOdent pen (KaVo, Germany) and TEP-test (V.P. Okushko, L.I. Kosareva, 1983). Mathematical analysis and verification of the accuracy of the results and the calculation of possible error values were carried out using the Statistica software and Microsoft Office Excel 2007. The statistical analysis of the received data was carried out using the Statistica 6.0 standard statistical software.
Results. In the studied regions, the decompensated degree of caries activity in children aged 5 to 11 years prevailed. In the group with a compensated degree of caries activity, the hygiene index was 2.2 ± 0.02 points and 2.0 ± 0.07 points (р < 0.05), with a subcompensated degree of caries activity – 2.7 ± 0.02 points, 2.6 ± 0.6 points; (р < 0.05), with decompensated degree of caries activity – 3.07 ± 0.02 points with temporary and 3.15 ± 0.6 points with variable bite. A significant decrease in caries resistance of enamel is observed among schoolers of Rakhiv school №1, in particular among children with a decompensated degree of caries activity, where this indicator is equal to 82.3%, which is significantly more than the result obtained among children in Uzhhorod school No. 20 (68.2% ).
Conclusions. It was statistically established that the presence of a decompensated degree of caries activity had a direct correlation with high rates of tooth enamel demineralization in all studied patients of both educational institutions (r = 0.87, p = 0.05).
BARIATRIC SURGERY IMPACT UPON OXIDATIVE STRESS MARKERS
Authors: Prodan Andriy , Dzhyvak Volodymyr
Published: December 2023

Obesity is characterized by excessive fat accumulation, disruption of redox homeostasis, and metabolic changes that are often associated with self-catalyzed lipid peroxidation, which generates 4-hydroxynonenal, a pluripotent bioactive product of polyunsaturated fat peroxidation, and acids. Bariatric surgery leads to restoration of redox balance and improvement of body metabolism.
Aim. The primary objective was to assess the impact of laparoscopic sleeve gastrectomy, laparoscopic gastropliction, bariatric artery embolization on changes in redox balance in patients with metabolic syndrome.
Materials and Methods. The work is based on the materials of clinical examination and surgical treatment of 44 patients with metabolic syndrome (MS): 17 men and 27 women aged 47 ± 6.75 years with a body mass index > 40 kg/m2. The control group included 12 people without manifestations of metabolic syndrome. Plasma levels of MDA, ox-LDL, TAA, catalase, total content of nitrates and nitrites were measured before and after (in 1, 3, 6 months) bariatric surgery (laparoscopic sleeve gastrectomy, laparoscopic gastropliction, bariatric artery embolization).
Results. We have established a tendency towards intensification of lipoperoxidation processes and reduction of protective resources of antioxidant protection. The indicators of the content of TBC-active products in the serum of MS patients were significantly higher (p ˂ 0.001). The indicators of TAA activity were significantly lower (by 1.6 times) in patients with MS compared to controls (p ˂ 0.001). However, catalase activity increased in our study. Thus, we found a 2.3-fold increase in catalase activity in MS patients compared to controls. The level of TBC-active products (MDA) increased significantly in patients with metabolic syndrome – by 1.64 times. After the bariatric interventions, we recorded a significant decrease in the content of MDA – the main marker that characterizes the activation of LPO, but this indicator did not reach the level of the control group after all three types of surgical intervention (LSG, LGP, BAE).
Conclusions. Bariatric surgery reduces the intensity of lipid peroxidation, nitrooxidative stress, which prevents underoxidized decay products from entering the bloodstream. However, the state and activity of the blood antioxidant system does not always objectively reflect changes in organs and systems.
From learner corpus to data-driven learning (DDL): Improving lexical usage in academic writing
Authors: HArtle Sharon
Published: December 2023

Despite considerable discussion in the literature (Flowerdew & Peacock, 2001; Hyland, 1998; Tang, 2012) competent English academic writing is still a problem which needs to be solved. English for Academic Purposes (EAP) teaching often focuses on specialized lexis, which may, however, be the area where academic writers need least help. The study of a small corpus of C2 level academic writing which consisted of the sub-genres of summary and discussion writing revealed that one key area which is problematic is collocation. This paper presents the results of this small corpus investigation into learner language and how it informed the classroom implementation of data-driven learning (DDL) to increase learner awareness of and ability to use collocations effectively in written academic English. The article briefly describes the corpus and the resulting teaching procedure adopted. The first step of this procedure is familiarization followed by experimentation using Sketch Engine (SkeLL).
Exploring interactive metadiscourse as a practical approach to enhancing academic writing skills of newly admitted undergraduate students in Nigeria
Authors: AKINSEYE TOLULOPE
Published: December 2023

Academic writing is a crucial aspect of undergraduate education, particularly for students in English as Second Language (ESL) contexts. This study investigates the use of interactive resources as discursive strategies in enhancing the academic writing skills of ESL undergraduates in Nigeria. A sample of 100 expository essays was used. The research employs both qualitative and quantitative designs. The qualitative component analyses the types and usages of discursive strategies employed in the selected expository writing, while the quantitative component involves the occurrence of these strategies. The results reveal transitional markers, frame markers, and code glosses were the most frequently used interactive markers in academic writing, while evidential and endophoric markers were used less frequently. These findings underscore the pedagogical significance of incorporating interactive resources into the teaching of academic writing skills for ESL undergraduate students.
EALP textbooks and the challenges of legal English education
Authors: Pennisi Giulia Adriana
Published: December 2023

Over the last thirty years English for Academic Purposes (EAP) has expanded, cutting across the domains of specialised discourse, and has shifted its focus to meet the needs of large numbers of non-native speaking students at the university level. In this regard, English for Academic Legal Purposes (EALP) can be defined as the teaching and learning of legal English as an ESP subject that includes the academic dimensions of EAP. This paper investigates how EALP textbooks has responded to the challenges of law school education. Reflecting on the pedagogic contributions of Carrick and Dunn (1985), Candlin, Bhatia, and Jensen (2002), and Prinsloo (2015), this paper begins diachronically with a sample of EALP-type textbooks from the point where Prinsloo completed his analysis. Drawing on these reviews, this paper attempts to provide some insights into the development of EALP-type textbooks and their response to the challenges of legal English education.
Writing in English in Italy– the ‘pre-history’ of academic writing
Authors: NAva Andrea
Published: December 2023

This article aims to investigate the evolution of L2 English writing instruction in the 20th century, focusing on the ‘pre-history’ of academic writing in Italy – when writing was mainly viewed as an ancillary activity, often added to grammar/translation language classes. To shed some light on the principles underlying L2 English ‘composition’ writing instruction, the article illustrates the findings of the analysis of a sample of English writing materials published in Italy between the 1940s and the 1990s. Against the background of a mostly stagnant institutional context, English writing pedagogy appears to have evolved in Italy throughout the 20th century as a result of wider social and cultural changes, as well as developments in applied linguistics. This evolution led to a reappraisal of the role of the learner writer, who was increasingly viewed as an active agent in the process of knowledge transformation.
The complexity of the grading system in Turkish higher education
Authors: GÜR Recep , KÖROĞLU Mustafa
Published: December 2023

Based on the academic performance grades of university students, various high-stakes decisions are made, including determinations of pass/fail status, the awarding of diplomas, and eligibility for placement in graduate education programs. According to the criteria used, the types of assessment are divided into two assessment, criterion-referenced assessments and norm-referenced assessments. When the grading system of state universities in Turkish higher education is examined, it has been observed that some universities use criterion-referenced assessment, some use norm-referenced assessment, and some use both assessment systems. The purpose of this research is to examine whether inter-university grading systems show significant concordance in the context of university students' letter grades or not. In other words, it is to reveal whether there are skew in the grading systems of public universities. In this context, 250 individuals were simulated in a way that their class/group achievement level would show a normal distribution. Among the public universities in the 2021-2022 Academic Performance Ranking of Universities (URAP), four state universities were determined in the first quarter, second quarter, third quarter, and last quarter. The letter grades of each student's academic success grade in the relevant universities were determined and it was examined whether there was a significant concordance between the letter grades of the students. In the study, it was concluded that in the context of university students' letter grades, inter-university grading systems generally do not show significant concordance. The findings are expected to contribute to the work of the Council of Higher Education and the University Education Commissions.
The Role of Forensic Accounting and Non-Financial Measurement for the Financial Audit
Authors: Mahsun Mohamad , Popoola Oluwatoyin Muse Johnson , Sari Rida Perwita
Published: December 2023

Due to a lack of competency, including knowledge and experience, non-financial measurement skills are now required by auditors in order to prove fraud. As a result, this research aims to identify the gap between the practice requirements and the output of the audit training centre and the role of the forensic accounting curriculum in filling that gap. This research examines the best strategies for establishing competent and reliable auditing practice results. The non-participatory observation data mining method is used in this study. The study discovered that the auditing education and training centre had not taught and did not have a fraud prevention and detection curriculum based on non-financial measurement. As a result, this study recommends that Training Centre develop the audit curriculum in accordance with The International Education Standard. Furthermore, this study suggests that auditing education and training centres involve forensic accounting practitioners in team-teaching, particularly investigative audit topics.
Determinants of Budgets Fraud for Handling COVID-19 in Makassar City
Authors: Ismawati Ismawati , Indriana Indriana , Rosidi Rosidi , Rusydi Mohamad Khoiru
Published: December 2023

This study aims to examine the determinants of budget fraud for handling COVID-19 in the city of Makassar. This study uses a survey method for data collection. The samples of this research are 171 employees who work in Local Government Organizations in Makassar City while the data analysis tool uses SMART PLS software.The results of this study indicate that the greater the pressure, opportunity, competence, and arrogance of a person, the greater the level of fraud that occurs in a country. However, different results were found on the rationalization variable that fraud that occurred in a country was not influenced by a person’s rationalization in justifying his actions. Moderation in this study shows that bureaucratic reform can weaken the relationship between pressure and opportunity for fraud. However, it strengthens the connection between justification, competence, and arrogance to the occurrence of fraud
Analysis of Performance Anomaly and Fraudster Profile for Fraud Prevention and Detection
Authors: Ramadhan Dona
Published: December 2023

The rapid development of technology provides us with a lot of data that can be used for various purposes, such as fraud risk management. Data analytics should be the basis for anti-fraud activities related to prevention and detection processes. This study aims to elaborate on the data analytics used in developing fraud red flags based on historical reports. By applying anomaly data analytics and demographic profiles of fraudsters, this study finds that performance anomalies contribute 68% to fraud, while 3 to 10 years of service without career advancement can trigger motivation to commit fraud. Finally, the paper recommends that data analytics should be followed by human approaches such as lifestyle audits and career advancement programs. Further research is expected to be able to complement other parameters for data analysis and use statistical methods to obtain more accurate results.
DESENVOLVIMENTO DA INTERNACIONALIZAÇÃO NO BRASIL NAS ÚLTIMAS DUAS DÉCADAS
Authors: Antonita do Nascimento Geisiane , Duarte Sibele Thaíse Viana Guimarães
Published: December 2023

Este ensaio teórico tem como propósito evidenciar como a internacionalização (acadêmica e estudantil) se desenvolveu no Brasil entre os anos de 2003 e 2020. Dados colhidos por meio da CAPES e do CNPQ demonstram que, ao longo dos anos, houve períodos de crescimento e queda na oferta de bolsas, assim como priorização de áreas específicas. As evidências apontam um claro “descompromisso” por parte dos últimos governos, no que tange a mobilidade acadêmica e estudantil. Decerto, a falta ou má aplicação de políticas públicas de fomento à internacionalização a médio e longo prazo podem ser desastrosas.
LIMITES E POSSIBILIDADES FORMATIVAS DAS ADAPTAÇÕES CURRICULARES NO ENSINO REMOTO PARA CONTATO E INSERÇÃO DE ESTAGIÁRIOS COM O CAMPO DE ESTÁGIO
Authors: Da Rosa Kessler Ana Emília , Rosa Gama Maria Eliza
Published: December 2023

Esse artigo objetivou compreender os limites e possibilidades formativas advindas das adaptações realizadas nos estágios curriculares no ensino remoto das licenciaturas da modalidade presencial da UFSM, para tanto realizamos uma pesquisa qualitativa documental em 11 PPC, por meio de roteiros para análise textual. Pimenta e Lima (2006), Ghedin, Oliveira e Almeida (2015) e Diniz-Pereira (2011) foram nossos principais aportes teóricos. Concluímos que os impactos foram irreparáveis à imersão no campo de estágio, ao mesmo destacamos que as TICs podem potencializar os processos formativos presenciais.
O PIBID NO CONTEXTO DA FORMAÇÃO DE PROFESSORES: TRAJETÓRIAS E DILEMAS
Authors: Vieira Odair Alves , Mello Ângela Rita Christofolo de
Published: December 2023

Este artigo tem como objetivo apresentar reflexões voltadas para as ações do PIBID, uma política pública de formação inicial de professores. Como suporte metodológico, realizaram-se análises de documentos legais que direcionaram as ações do programa no período de 2007 a 2020. A discussão se embasa nos contributos de Avritzer (2018), Ball e Maguire (2016), Campelo (2019), Penin (2001), Zeichner (2003; 2013), entre outros. As análises denotaram que os retrocessos sofridos nesta política, nos últimos anos, mostram uma direção contrária ao estado democrático e se aproximam da lógica neoliberal.
MILITARIZAÇÃO DE ESCOLAS E A GESTÃO DEMOCRÁTICA: OS SENTIDOS DA DESDEMOCRATIZAÇÃO DO ENSINO PÚBLICO
Authors: Goulart Janaina Moreira de Oliveira , Patti do Amaral Daniela
Published: December 2023

O processo de militarização das escolas públicas no Brasil reúne indicativos de uma desdemocratização do ensino público, em um movimento oposto ao princípio constitucional de gestão democrática. Tal processo, mais especificamente no estado de Goiás, não é recente, e se constitui em uma dinâmica que ocorre há décadas. Analisamos os modelos de militarização que envolvem as Escolas Públicas Militarizadas (EPM) e as Escolas Cívico-militares (Ecim), considerando a ideia de que, no Brasil, há duas gerações de escolas públicas civis transformadas em escolas públicas militarizadas (Goulart, 2022).
THE TEACHING PROCESS IN TIMES OF COVID-19: BETWEEN THE POSSIBLE AND THE IDEALIZED
Authors: Carius Ana Carolina , Rodrigues Scartoni Fabiana
Published: December 2023

This article aims to study the development of so-called remote teaching during the closure of Brazilian schools due to the COVID-19 pandemic. Therefore, a research approach was chosen mixed in a convergent way through a case study of the municipal system of Petropolis education. The main objective of the research is to evaluate the existence (or not) of pedagogical theories, such as new school, technician, or socio-critical pedagogy, that have supported the different pedagogical practices carried out during the school closing period. Through questionnaires and semi-structured interviews, conducting a qualitative study on the topic was possible using Content analysis. It is concluded that the adaptation to remote teaching was made suddenly without preparing teachers, students, managers, and families. Little was reflected about existing pedagogical theories to improve the effectiveness of  Education during the school closure period.
Development and analysis of thermal flow field: a new experimental approach
Authors: Pal Arun Kiran
Published: December 2023

A new approach to experimental investigation of thermal flow field produced along an isothermal plate of finite dimensions in free convection is presented. The experimental procedure is based upon a flow visualization technique developed earlier by author. The contribution of this paper apparently is that a physical grid placed in the light path of a photographic flow visualization system enhances the ability to discern growth of thermal flow field produced due to temperature difference between a body and its surroundings. The results obtained from flow visualization experiment are verified with a correlation predicted by earlier published work.
Test and application of movable steel barrier with grade SB light composite corrugated beam
Authors: Zhang Aling , Bu Qianmiao , Zhang Wen , He Guomeng , Deng Yong
Published: December 2023

In this study, movable steel barrier with grade SB light composite corrugated beam is designed, which addresses the problems of the prior central partition belt portable guardrail in terms of easy mobility, local safety, easy construction, and other indications. This guardrail employs explicit algorithms to conduct a dynamic finite element simulation analysis and a real vehicle crash test, and verifies the guardrails' blocking, guiding, and buffering functions in accordance with the SB level collision conditions listed in the Standard for Safety Performance Evaluation of Highway Barriers (JTG B05-01-2013). According to the results, the safety performance of SB grade lightweight composite corrugated beam movable steel guardrail meets the requirements of the Standard for Safety Performance Evaluation of Highway Barriers (JTG B05-01-2013). In addition, the guardrail can be opened for 12 meters in 1 minute and returned to close in 2 minutes. The opening and restoration of the movable guardrail is superior to the previous central divider movable guardrail. This guardrail has been tried for some high-speed and its safety performance has been verified again in actual high-speed vehicle collisions.