bluuebunny/crossref_metadata_2025 huggingface dataset:
Pembelajaran Sosial Termediasi dan Aktivisme Media Sosial untuk Pola Hidup Berkelanjutan di Indonesia
Authors: Cahyaningtyas June , Udasmoro Wening , Sofjan Dicky
Published: November 2021

The notion of social media activism has often been linked with both event and heroic acts in the public with the aim to transform the society. The problem with this framework is its reliance upon performance, while lacking of awareness on the mundane aspects of everyday life, where public issues seep into with its own complexity. To fill this gap, the study uses Social Learning Theory as well as Uses and Gratification Theory to understand to what extent social media supports learning for sustainable living. By way of an ethnographic study on online community, the study found that the women under study have utilized the social media strategically to respond to the health issue and environmental problem, especially after the Covid-19 pandemic, through the discourse practice of sustainable living. Keywords: online community, social media activism, social learning, sustainable living.
User-Centred Design of a Final Results Report for Participants in Multi-Sensor Personal Air Pollution Exposure Monitoring Campaigns
Authors: Robinson Johanna Amalia , Novak Rok , Kanduč Tjaša , Maggos Thomas , Pardali Demetra , Stamatelopoulou Asimina , Saraga Dikaia , Vienneau Danielle , Flückiger Benjamin , Mikeš Ondřej , Degrendele Céline , Sáňka Ondřej , García Dos Santos-Alves Saul , Visave Jaideep , Gotti Alberto , Persico Marco Giovanni , Chapizanis Dimitris , Petridis Ioannis , Karakitsios Spyros , Sarigiannis Dimosthenis A. , Kocman David
Published: November 2021

Using low-cost portable air quality (AQ) monitoring devices is a growing trend in personal exposure studies enabling a higher spatio-temporal resolution and identifying acute exposure to high concentrations. Comprehension of results by participants is not guaranteed in exposure studies. However, information on personal exposure is multiplex, which calls for participant involvement in information design to maximise communication output and comprehension. This study describes and proposes a model of a user centred design (UCD) approach for preparing a final report for participants involved in a multi-sensor personal exposure monitoring study performed in seven cities within the EU Horizon 2020 ICARUS project. Using a combination of human-centred design (HCD), human-information interaction (HII) and design thinking approaches, we iteratively included participants in the framing and design of the final report. User needs were mapped using a survey (n=82), and feedback on the draft report was obtained from a focus group (n=5). User requirements were assessed and validated using a post-campaign survey (n=31). The UCD research was conducted amongst participants in Ljubljana, Slovenia and the results report was distributed among the participating cities across Europe. The feedback received made it clear that the final report was well-received and helped participants better understand the influence of individual behaviours on personal exposure to air pollution.
ColoSTEM Dx Kit: Innovative Alliance of Cancer Stem Cells and Glycosylation for Earlier Prediction of Colon Cancer Aggressiveness and Prognosis
Authors: Blondy Sabrina , Durand Stéphanie , Lacroix Aurélie , Christou Niki , Bouchaud Charline , Peyny Maud , Battu Serge , Chaunavel Alain , Carre Vincent , Jauberteau Marie-Odile , Lalloue Fabrice , Mathonnet Muriel
Published: November 2021

Nowadays, colon cancer prognosis still difficult to predict, especially in the early stages. Recurrences remain elevated, even in the early stages after curative surgery. Carcidiag Biotechnologies has developed an immunohistochemistry (IHC) kit called ColoSTEM Dx, based on a MIX of biotinylated plant lectins that specifically detects colon cancer stem cells (CSCs) through glycan patterns that they specifically (over)express. A retrospective clinical study was carried out on tumor tissues from 208 non-treated and 21 treated patients with colon cancer, that were stained by IHC with the MIX. Clinical performances of the kit were determined, and prognostic and predictive values were evaluated. With 78.3% and 70.6% of diagnostic sensitivity and specificity respectively, our kit shows great clinical performances. Moreover, patient prognosis is significantly poorer when the MIX staining is “High” compared to “Low”, especially at 5-years of overall survival and for early stages. The ColoSTEM Dx kit allows an earlier and a more precise determination of patients’ outcome. Thus, it affords an innovating clinical tool for predicting tumor aggressiveness earlier and determining prognosis value regarding therapeutic response in colon cancer patients.
Aptamer Applications in Neuroscience
Authors: Ozturk Meric , Nilsen-Hamilton Marit , Ilgu Muslum
Published: November 2021

Being the predominant cause of disability, neurological diseases have received much attention from the global health community. Over a billion people suffer from one of the following neurological disorders: dementia, epilepsy, stroke, migraine, meningitis, Alzheimer's disease, Parkinson’s disease, multiple sclerosis, amyotrophic lateral sclerosis, Huntington’s disease, prion dis-ease, or brain tumors. Diagnosis and treatment options are limited for many of these diseases. Aptamers, being small and non-immunogenic nucleic acid molecules that are easy to chemically modify, offer potential diagnostic and theranostic applications to meet these needs. This review covers pioneer studies to apply aptamers, which show promise for future diagnostics and treatments of neurological disorders that pose increasingly dire worldwide health challenges.
Developing Verification and Optimization Models for Corona Discharge Suppression in High Voltage AC and DC Capacitor Banks
Authors: Javadi Mohammadjavad
Published: November 2021

Capacitor banks are widely used in current electrical transmission systems in order to improve power quality and increase efficiency. Utilizing high voltage components such as, shunt capacitors in the power grid imposes new challenges to the system which are required to be addressed. One of these challenges is corona discharges that can have negative impacts on capacitor banks such as power loss, insulator erosion followed by equipment failure, and radio interference. Although previous studies have almost exclusively focused on optimization of corona suppression rings for transformers and transmission lines, no specific studies have conducted regarding high voltage capacitor banks. This paper presents a novel study concerning verification and development of corona discharge suppression models on AC and DC capacitor banks with two different voltage levels. The employed method is based on the Maxwell’s equations and finite element method (FEM) which is implemented with the help of COMSOL Multiphysics© software. Results have verified the necessity of suppression methods as well as the efficiency of proposed solutions. Corona inception voltage levels are identified and effective factors on its appearance are reviewed. Analyses of proposed solutions have shown significant improvements in optimization of corona suppression methods as well as enhancement of maintenance maneuverability.
Optimum Treatment Strategy in Chronic Coronary Syndromes: the New Trials vs the Current Guidelines
Authors: Bershtein L. L. , Zbyshevskaya E. V. , Gumerova V. E.
Published: November 2021

Coronary revascularization is one of the most studied types of interventions in cardiology, but there is no consensus among specialists about the indications for its implementation in patients with chronic coronary syndromes (CCS). The data of recently completed clinical trials on the role of revascularization in CCS clearly contradict the current Guidelines, emphasizing the high effectiveness of modern conservative therapy. This paper discusses the main recommendations of the most significant American and European Guidelines on myocardial revascularization, and also analyzes the appropriateness of revascularization to improve the prognosis and symptoms in chronic coronary syndromes in view of the new research data, primarily the ISCHEMIA study (NCT01471522). Its strengths and limitations are discussed in detail. The data on the expediency of revacularization in CCS, obtained after the completion of ISCHEMIA and its potential significance, as well as subgroup analyses of ISCHEMIA, including in the most important ‘problem’ subgroups (3-vessel disease, proximal LAD disease, severe ischemia on stress test, etc.) are discussed. The paper also discusses the important achievements in modern drug therapy of chronic coronary syndromes, primarily antithrombotic therapy. The data of the COMPASS study (NCT01776424) are discussed, based on which the addition of a second antithrombotic drug – rivaroxaban in a small dose (2.5 mg BID) – is recommended for patients with CCS without atrial fibrillation who have high-risk characteristics. Indications the administration of dual antithrombotic therapy to patients with CCS, comparative results of its various regimens in relation to the prevention of cardiovascular complications, the risk of bleeding and the net clinical effect are given.
A Randomized Open Clinical Study of the Atherosclerosis Treatment Information Video Effect on Adherence to Long-Term Therapy in Patients with Cardiovascular Diseases
Authors: Bulaeva Yu. V. , Naumova E. A. , Semenova O. N. , Kanaeva T. V. , Popov K. A. , Tyapayeva А. R.
Published: November 2021

Aim. Study the effect of a study video, which was created by researchers and devoted to the atherosclerosis development and the effect of statin therapy on atherosclerotic plaque, on adherence to long-term therapy in patients with high or very high risk of cardiovascular complications.

Material and methods. 120 patients admitted to hospital with cardiovascular diseases were included in the study. Patients were randomized into 2 groups: in the main group (n=60), the information video edited by the researchers was shown to patients on the eve of discharge, in addition to a printed brochure on lifestyle and diet modification, and in the control group (n=60), patients were given only a standard brochure. The motivating video shows the damage to the cardiovascular system by the atherosclerotic process and the beneficial effect on the body of constant intake of statins. After 1 and 3 months after discharge from the hospital, telephone calls were made, after which the patients had to visit the center for an objective examination by a researcher and control of laboratory parameters. After 1 month, 110 patients visited the center, after 3 months, 98 respondents visited the center.

Results. The group with the information video demonstration noted more frequent adherence to medical recommendations compared to the control: after 1 month, 52 (96%) patients continued treatment versus 48 (86%) patients, 3 months after discharge 48 (96%) patients continued treatment versus 38 (79%) patients (p<0.05). After 1 month, 38 (70%) patients in the intervention group continued taking statins versus 29 (43%) respondents in the control group (p<0.05), 3 months after discharge, 40 (80%) patients in the intervention group continued to take statins versus 33 (69%) control patients (p<0.09).

Conclusion. Demonstration of a motivating video about the effect of statins on the atherosclerosis course increases patient adherence to medicinal therapy, including adherence to statins.
Safety and Effectiveness of Pharmacologic Conversion of Atrial Fibrillation and Flutter: Results of Multicenter Trial. Part II: Assessment of Safety
Authors: Mironov N. Yu. , Yuricheva Yu. A. , Vlodzyanovskiy V. V. , Sokolov S. F. , Dzaurova Kh. M. , Golitsyn S. P. , Shubik Yu. V. , Berman M. V. , Medvedev M. M. , Rivin A. E. , Parkhomchuk D. S. , Barybin A. E. , Balandin D. А. , Batalov R. E. , Terekhov D. V. , Evstifeev I. V. , Kildeev I. R. , Pyataeva O. V. , Zenin S. A.
Published: November 2021

Aim.We aimed to assess safety and effectiveness of class III antiarrhythmic drug Refralon for conversion of atrial fibrillation (AFib) and flutter (AFl) in post-registration trial and to compare data of primary center (National medical research center in cardiology) with data of other hospitals.

Material and Methods. We performed retrospective cohort study in 727 patients (451 enrolled in primary center and 276 enrolled in other hospitals) admitted between June 24, 2014 and June 24, 2019. Refralon was administered for conversion of AFib and AFl in intense care units in escalating doses (10-30 micrograms/kg) intravenously.

Results.Conversion of AFib and AFl into sinus rhythm was achieved in 53,6% after administration of 10 mcg/kg dose, in 73% after administration of 20 mcg/kg dose and in 91,6% after administration of Refralon in dose up to 30 mcg/kg. No mortality and no major adverse cardiac events registered in our study. Asystole >3.0 sec observed in 5% (35 of 727) of patients): in 5% (24 of 451) of patients enrolled in primary center and in 4% (11 of 276) of patients enrolled in other hospitals; 95% confidence interval (CI) [-0.09; 0.113]. Asystole> 5.0 s observed in 1.7% of patients who further required non-urgent implantation of a permanent pacemaker due to manifestations of sinus node dysfunction. Cardiac conduction disturbances (exclusively sinus bradycardia) were registered in 7% (53 of 727) patients: in 8% (37 of 451) of patients enrolled in primary center and in 6% (17 of 276) of patients enrolled in other hospitals; 95% CI: [-0.1; 0.15]. Only 0.14% of patients had symptomatic sinus bradycardia that resolved after atropine injection. Ventricular arrhythmias (exclusively Torsade de pointes tachycardia in excessive QT interval prolongation) were registered in 1.7% (12 of 727) patients: in 2% (9 of 451) of patients in primary center and in 1% (3 of 276) of patients of other hospitals; 95% CI: [-0.06; 0.08]. QTc interval prolongation to values >500 ms documented in 19% (138 of 727) of patients: in 21% (95 of 451) of patients in primary center and in 16% (43 of 276) of patients in other hospitals; 95% CI: [-0.13; 0.24].

Conclusion:In post-registration multicenter trial Refralon demonstrated good safety profile in conversion of AFib and AFl. Potential risk of TdP tachycardia mandates precautions with the use of the drug. In other hospitals Refralon did not demonstrate lower safety than in primary medical center.
Impact of Gut Microbiota on the Risk of Cardiometabolic Diseases Development
Authors: Vasilyeva L. E. , Drapkina O. M.
Published: November 2021

Obesity is a multifactorial disease that leads to excessive adipose tissue accumulation, mainly visceral fat. Importance and prevalence of obesity has increased significantly in recent decades all over the world. Until now, the pandemic of obesity has been associated more to lifestyle changes: excessive eating and low physical activity. In recent years, special attention has been paid to studying of composition and functions of intestinal microbiota as major factor in development of obesity and related comorbidities, such as hypertension, cardiac ischemia, heart failure and others. It is proved that gut microbiota affects extraction, accumulation and consumption of energy derived from food, lipid metabolism and immune response. It is also revealed that composition of the microbiota is different in thin and obese people. Thus, study of the relationship between intestinal microbiota composition and risk factors for cardiovascular diseases, in particular obesity, is an actual task. The purpose of this review is analyzing of literature about assessment of relationship between composition and functions of intestinal microbiota in the diagnostics, prevention and treatment of obesity and cardiovascular diseases.
Relationship between Chemotherapy and Atrial Fibrillation: Clinical Case
Authors: Avagimyan A. A. , Mkrtchyan L. H. , Gevorkyan A. A. , Kononchuk N. B. , Kakturskiy L. V. , Djndoyan Z. T.
Published: November 2021

The aim of this article is to represent the characterization of the clinical case of chemotherapy-related atrial fibrillation (AF) development in the young woman, elaborated as a result of multiple neoadjuvant and adjuvant modes of the intake of chemotherapy (both anthracycline based and non-anthracycline ones). In this case, the noted disturbances of heart rhythm should be recognized as a manifestation of cardiotoxicity. The latter implies the degree of detrimental effect of chemotherapeutical medication on the morphophynctional parameters of the cardiovascular system. Anthracycline drugs, being highly effective chemotherapytical agents, provide well-known toxic effects on the heart and vessels. Anthracycline mediated cardiotoxicity is a well- known veracity that dates back to the 60s of the last century, but up to now this medication sustains irreplaceable components of big volume of chemotherapy modes. Moreover, it should be noted that relatively newer drugs also posses certain cardiotoxicogenic potential.
Problematika Evaluasi Pembelajaran Bahasa Arab di Masa Pandemi
Authors: Arsyad Itsarul Ikhwan  , Syihabuddin  , Ali Mad
Published: November 2021

This study aims to determine the problem of evaluating Arabic learning. This research used a qualitative descriptive and subjects were Arabic language teachers and grade IX students at SMPIT Insan Rabbani, Bekasi Barat. The data collection technique used observation, interview, and documentation techniques, while the data validation technique used triangulation techniques, namely triangulation of data sources and methods. data analysis. The results showed that: (1) the planning of the evaluation of Arabic learning at SMPIT Insan Rabbani is quite good; (2) the implementation of the evaluation of Arabic learning is carried out using the google form media; (3) the problem is that it is difficult to know the students’ Arabic skills and the character or behavior of the students are difficult to monitor. The location of the house is not covered by the internet network, including minimalist student internet quotas, or an unstable internet network. Efforts made by teachers in dealing with these problems by temporarily asking students to move locations that are accessible to the internet network.
Анализ динамики эпидемического процесса COVID-19 в мире за неделю с 30.10.2021 г. по 05.11.2021 г.
Authors: Зимирова Анастасия , Поспелов Михаил , Иванова Александра , Дмитриева Людмила , Чумачкова Елена , Сафронов Валентин , Карнаухов Игорь , Щербакова Светлана , Кутырев Владимир
Published: November 2021

В обзоре представлен анализ эпидемиологической ситуации в странах мира по COVID-19, за неделю с 30.10.2021 г. по 05.11.2021 г.
Buku Ajar Psikologi Perkembangan Manusia
Authors:   Vanda Rezania, Mariyati Lely Ika
Published: November 2021

Alhamdulillahirabbil’alamin, puji syukur senantiasa penulis panjatkan atas kehadirat Allah SWT, shalawat serta salam senantiasa saya sampaikan kepada junjungan nabi besar kita nabi Muhammad SAW, sehingga pada hari ini mampu menuntaskan penulisan buku ajar perdana.Tujuan penyususnan buku ini yaitu untuk memudahkan pembaca khususnya mahasiswa/i dalam memahami perkembangan hidup manusia mulai dari di dalam kandungan sampai dengan memasuki usia dewasa akhir baik dari tahap fisik, kognitif dan juga emosi. Juga diiluntrasikan dengan gambar dan dilengkapi dengan jurnal2 pendukung. Buku ini dibuat sebagai bahan ajar bagi mahasiswa/i secara berseri, yakni jilid 1 (sebelum UTS) dan jilid 2 (paska UTS hingga UAS).Penulis menyadari sepenuhnya bahwa buku ini masih jauh dari kesempurnaan, meskipun kami telah berusaha sebaik-baiknya. Oleh karena itu, penulis mengharapkan masukan dan saran untuk penyempurnaan buku ini di masa yang akan datang. Penulis mengucapkan terima kasih kepada semua pihak atas dukungan yang telah diberikan, khususnya kepada UMSIDA Press yang telah memberikan kesempatan hingga tulisan ini dapat diterbitkan. Semoga buku ini dapat memberikan manfaat bagi siapa saja yang membutuhkan
Environmental magnetism evidence for longshore drift distribution of Fe-bearing phases: An example from the Brazilian southeastern coastal region
Authors: Silveira Vitor E.P. , dos Santos Natália B. , Franco Daniel R. , la Terra Emanuele F. , Feinberg Joshua M. , Scorzelli R.B. , Fontes Magda B. , Bertolino Luiz C. , Cagliari Joice , de Souza Marcelo K. , Hartmann Gelvam A.
Published: November 2021

The accumulation of heavy minerals along a part of the southeastern Brazilian coast (northern coast of Rio de Janeiro State, Brazil) provides insight into sedimentary provenance and transport by longshore drift. In particular, recent work has focused on heavy minerals as tracers to determine sedimentary sources and transport pathways, indicating a mineral distribution according to the northward and southward coastal transport cells. There is also evidence of heavy-mineral transport by the Paraíba do Sul River. However, research has not been done in this area on the opaque fraction (iron oxides and oxyhydroxides), which are good tracers for provenance and distribution processes. Here we intend to: 1) characterize the spatial variation of the magnetic properties of heavy-mineral contents throughout a coastal area of the Itabapoana and Paraíba do Sul River mouths (state of Rio de Janeiro), 2) evaluate the contribution of coastal dynamics on the mineral distribution along this coastal area, 3) provide contributions on the provenance of iron-bearing minerals. Results indicate that a bimodal pattern was observed for the magnetic remanence of magnetite and hematite near the Paraíba do Sul River. For the northernmost section, goethite exhibits a gradual increase in concentration towards the central part of the study area. Additionally, higher heavy-mineral content is observed at the northern coastal section, which may be related to coastal morphology, which is exposed to high-energy beach processes. It is possible to verify three sampling groups in accordance with their magnetic properties: 1) the “southernmost” and 2) the “northernmost” groups, suggesting a mineral provenance related to the Paraíba do Sul and Itabapoana rivers, respectively, as possible major sources, and 3) another at the intermediate section of the area, possibly linked to the erosion of the Barreiras Formation bluffs. Results also show a correspondence between the variability of magnetic parameters and the main directions of the coastal transport cells.
Lithology and reservoir properties of the Delaware Mountain Group of the Delaware Basin and implications for saltwater disposal and induced seismicity
Authors: Smye Katie , Banerji D. Amy , Eastwood Ray , McDaid Guin , Hennings Peter
Published: November 2021

Deepwater siliciclastic deposits of the Delaware Mountain Group (DMG) in the Delaware Basin (DB) are the primary interval for disposal of hydraulic fracturing flowback and produced water from unconventional oil production. Understanding the storage capacity of the DMG is critical in mitigating potential risks such as induced seismicity, water encroachment on production, and drilling hazards, particularly with likely development scenarios and expected volumes of produced water. Here we present a basin-wide geologic characterization of the DMG of the Delaware Basin. The stratigraphic architecture, lithology, and fluid-flow properties including porosity, permeability, amalgamation ratios, and pore volumes, are interpreted and mapped. Lithologies are predicted using gamma-ray and resistivity log responses calibrated to basinal DMG cores and outcrop models. Sandstones exhibit the highest porosity and permeability, and sand depocenters migrate clockwise and prograde basinward throughout Guadalupian time. Permeability is highest at the top of the Cherry and Bell Canyon formations of the DMG, reaching tens to hundreds of millidarcies in porous sandstones. Porous and permeable sandstones are fully amalgamated at the bed scale, but at the channel scale, most sandstones are separated by low-permeability siltstones or carbonates where net sandstone is less than 30%. This geologic characterization can be used to assess the regional storage capacity of the DMG and as input for dynamic fluid-flow models to address pore-pressure evolution, zonal containment, and induced seismicity.
Knowledge and treatment-seeking behavior among malaria suspected patients in two hospitals of district Malakand
Authors: Khan Wali , shah Syed Ali , Tahir Muhammad , Ullah Zakir , Ullah Nesar , Rahman Shams Ur
Published: November 2021

BackgroundMalaria remains a significant public health problem over the last two decades in Pakistan. to prevent malaria infection and develop malaria-free zones, understanding the knowledge, treatment-seeking behavior, and preventive measures toward the malaria infection of the inhabitant are necessary. This study is designed to assess the knowledge, malaria preventive measures, treatment-seeking behaviors, and socio-economic profiles, among suspected malaria patients in district Malakand, Pakistan.MethodsCurrent research was a hospital-based cross-sectional study, in which patients attending DHQ hospital Batkhela and THQ hospital Dargai were recruited. A pre-tested semi-structured questionnaire was used to collect demographic characteristics, knowledge, and treatment-seeking behavior of the patients for malaria infection. Data were analyzed using SPSS version 20.ResultsA total of 1100 malaria suspected individuals were interviewed. The respondent’s ages ranged from 3-80 years, with a mean of 19.5 years. Participation of Males was more than female, 54.3% and 45.6% respectively. Participants belonging to education departments were more participated in the survey (55%) than others, while most of the individuals were from rural areas (78.1%), and the number of individuals >8 is higher than below <8 members. The majority of the respondents (76.2%) were voted to sleep uncovered than covered (23.7%). Most of the individuals (83.36%) were of the view to use allopathic treatments after getting malaria while only 16.63% were used homeopathy, and financial issues were reported as the major reason for the delay in treatment. Regarding treatment time after getting malaria, 68.8% were received within a week and, 31.3% were within 24 hours. Most of the infected individuals (87.9%) were known that mosquitoes as the causing source of malaria infection, and can be controlled by eliminating breeding grounds, using mosquito repellents and bed net 86%, 7.2%, and 6.6% respectively. ConclusionsMalakand is one of the malaria-endemic regions of Pakistan. The present study highlighted that the majority of the respondents have good knowledge about malaria infection, mode of transmission of the plasmodium parasite, and preventive measures. Further strategies are required for the control of malaria infection.
CNN-Based Flow Control Device Modelling On Aerodynamic Airfoils
Authors: Portal-Porras Koldo , Fernandez-Gamiz Unai , Zulueta Ekaitz , Ballesteros-Coll Alejandro , Zulueta Asier
Published: November 2021

Wind energy has become an important source of electricity generation, with the aim of achieving a cleaner and more sustainable energy model. However, wind turbine performance improvement is required to compete with conventional energy resources. To achieve this improvement, flow control devices are implemented on airfoils. Computational Fluid Dynamics (CFD) simulations are the most popular method for analyzing this kind of devices, but in recent years, with the growth of Artificial Intelligence, predicting flow characteristics using neural networks is becoming increasingly popular. In this work, 158 different CFD simulations of a DU91W(2)250 airfoil are conducted, with two different flow control devices, rotating microtabs and Gurney flaps, added on its Trailing Edge (TE). These flow control devices are implemented by using the cell-set meshing technique. These simulations are used to train and test a Convolutional Neural Network (CNN) for velocity and pressure field prediction and another CNN for aerodynamic coefficient prediction. The results show that the proposed CNN for field prediction is able to accurately predict the main characteristics of the flow around the flow control device, showing very slight errors. Regarding the aerodynamic coefficients, the proposed CNN is also capable to predict them reliably, being able to properly predict both the trend and the values. In comparison with CFD simulations, the use of the CNNs reduces the computational time in four orders of magnitude.
Characterization of the Chemical Components of the Extracted Carduus Pycnocephalus L, and Assessment of Its Potential Novel Antioxidant, Antibacterial, and Anticancer Activities
Authors: Hayyany Luay El , El‐Halawany El‐Sayed , Soliman Hoda , El-Amier Yasser
Published: November 2021

Carduus pycnocephalus L, which is related to the Astraceae family, was well-known as a privileged medicinal plant that has innumerable respected biological potency. The current research aims to identify the chemical constitutes of the essential oils of the extracted C. pycnocephalus by Gas Chromatography-Mass Spectroscopic analysis (GC-MS) and to assess the biological profiles of the plant and its botanical ingredients as a precise antioxidant, and anticancer, as well as, antimicrobial agents. The extraction process of the medicinal plant by methanol provided a possibility to extract and identify the polar chemical constitutes that have the most effective categories of components. The DPPH antioxidant potency of the botanical ingredients of the plant indicated that the flower extract is the most potent with IC50 = 30.69 mg/L followed by leaves (IC50= 32.78 mg/L), stem (IC50= 41.31 mg/L), and root (IC50= 46.84 mg/L). The antibacterial activities of the root, stem, leaf, and flower extracts of C. pycnocephalus exhibited remarkable potency to kill or inhibit the growth of the bacterial species. Leaf, and flower extracts revealed the most potent activities than the antibiotic standards against E. coli, S. typhimurium, and B. cereus species with inhibition zones ranged from 20-26 mm. Also, the extracted C. pycnocephalus revealed a moderate cytotoxic effect against hepatocellular carcinoma (HepG2) tumor cell line using MTT assay with IC50= 46.2 µg/mL. The experimental interpretations inveterate the potential of C. pycnocephalus extract indicated its biological impacts as antioxidant, antibacterial, and moderate cytotoxic agents that provided the ease of using it in cancer therapy.
Prognostic impact of advanced lung cancer inflammation index (ALI) on patients with adenocarcinoma of esophagogastric junction (AEG) after radical resection
Authors: Liao Qianchao , Yang Zifeng , Hu Xu , Zheng Chengbin , Feng Huolun , Deng Zhenru , Zheng Jiabin , Wang Junjiang , Hu Weixian , Li Yong
Published: November 2021

Background
To evaluate the prognostic impact of the advanced lung cancer index (ALI) in patients with the adenocarcinoma of esophagogastric junction (AEG) after radical resection.
Methods
The data of patients with AEG after radical resection at Guangdong Provincial People’s Hospital from January 2008 to December 2018 were retrieved. The cutoff value of ALI was determined and the prognostic impact of clinicopathological factors and ALI were analyzed. A nomogram based on the independent prognostic factors for overall survival was then built.
Results
A total of 147 patients were eligible and based on a cutoff of ALI 43.1, 90 (61.2%) and 57 (38.8%) patients were classified in a low- (ALI༜43.1) and high-ALI (ALI༞43.1) group. Multivariate Cox proportional hazard analysis showed that low-ALI was associated with poor overall survival (OS) (p༜0.001, HR 2.541, 95%CI 1.408-4.410) and disease-free survival (DFS) (p=0.021, HR 1.789, 95%CI 1.020-2.674). In subgroup analysis, low-ALI was independent predictor for OS (p=0.001, HR 2.628, 95%CI 1.467-4.707) in stage III/IVA AEG patients. A nomogram for OS estimation was constructed and the C-index was 0.699 (95%CI 0.636-0.762) and the calibration plots showed satisfactory consistency between actual observation and nomogram-predicted OS probabilities. Further, satisfactory predictive accuracy for 1-, 2-, and 3-year OS rates with an area under the curve of 0.736, 0.712 and 0.697, respectively, was observed.
Conclusions
ALI was an independent prognostic factor for AEG patients after radical resection, and demonstrated promising ability for risk stratification of AEG, especially in advanced-stage disease.
MiR155 Affect the Cerebral Ischemic Injury by Rheb/mTOR Signaling Pathway
Authors: Chang Le , Xue Yu-Ying , Zhu Xu-Rong , Tian Ye , Liu Zhi-Qin , Gu Nai-Bin , Jiang Yi , Ma Yue , Yong Fang , Jing Yun-Yun , Guo Hua , Yan Yu-E , Di Zhengli
Published: November 2021

Ischemic stroke remains to be a leading cause of death and disability worldwide at present. Cerebral ischemia/reperfusion injury (CIRI) is a critical pathogenesis leading to a poor prognosis for ischemic stroke patients.Recent studies have found that miR155 may be involved in the occurrence of CIRI after stroke, but it’s role and specific mechanism are not completely clear.Therefore, this study investigated the effects of miR155 expression levels on mortality, cerebral infarction volume and neuronal apoptosis in MCAO/R rats by changing the expression level of miR155 in the ischemic penumbra (IP) region of rats. QRT-PCR and Western Blotting were used to detect the expression changes of Rheb, mTOR, 4EBP1 and S6K1 under different miR155 expression levels. The results showed that inhibition of miR155 could reduce the mortality, the volume of cerebral infarction and the number of neuronal apoptosis in MCAO/R rats.The mRNA and protein expressions of Rheb, mTOR, 4EBP1 and S6K1 were increased after inhibition of miR155, and vice versa. It suggested that inhibition the expression of miR155 could alleviate CIRI in the IP by activating Rheb/mTOR signaling at the transcriptional level. At the same time, we found that the phosphorylation level of mTOR signaling pathway were also increased after inhibition of miR155, indicating that autophagy level regulated by mTOR signaling pathway may be involved in the CIRI.
Mechanical /thermal Shock Properties and Failure Mechanisms of Cf/SiBCN Composites Effect of Sintering Densification and Fiber Coating
Authors: Niu Zi-bo , Wang BingZu , Pan Lijun , Li Daxin , Jia Dechang , Yang Zhihua , Peng Hao , Zhou Yu
Published: November 2021

In this work, resin derived carbon coating was prepared on carbon fibers by polymer impregnation pyrolysis method (PIP), and then Cf/SiBCN composites were prepared by hot pressing process. The effects of sintering densification and fiber coating on microstructure, mechanical properties, thermal shock resistance, and failure mechanisms of the composites were studied. Fiber bridging hinders the sintering densification, causing more defects in fiber-dense area and lower strength. However, higher sintering temperature (1800-2000℃) can improve mechanical properties significantly, including bending strength, vickers hardness, and elastic module, because further sintering densification enhances matrix strength and fiber/matrix bonding strength, while the change of fracture toughness is not obvious (2.24-2.38 MPa·m1/2) due to counteraction of higher debonding resistance and less pull-out length. However, fiber coating improves fracture toughness greatly via protecting carbon fibers from chemical corrosion and damage of thermal stress and external stress. Due to lower coefficient of thermal expansion, lower fiber loading ratio, less stress concentration at the fiber/matrix interface and better defect healing effect, lower sintering temperature favor thermal shock resistance of composites and thermal shock recession mechanisms are the damage of interface.
In vitro effect of aqueous extract of fresh cassava leaves (Manihot esculenta, Crantz) on the larvae of Haemonchus contortus as an intestinal parasite of sheep.
Authors: Medeiros Ana Flávia Lopes , Cereda Marney Pascoli Cereda , Braz Gabriel Furrer Matos
Published: November 2021

Cassava is frequently fed to animals. In the case of sheep, the producer relates consumption to a reduction in the parasite load. The literature has proven the effect of phenolic compounds as an anthelmintic in vivo, but no evidence for cyanogenic compounds, also present in all parts of the cassava plant, was found. A controlled in vitro bioassay was used to evaluate the aqueous extract of fresh cassava leaves. The efficiency parameter was the immobility of Haemonchus contortus larvae at the L3 stage, also used to evaluate commercial anthelmintics. Cell culture plates with 100 active L3-stage larvae per well were used, being each replicate constituted by three wells. Aqueous extract of fresh cassava leaves (FCL), Ivomec® 0.01% (PCI) as the positive control, and distilled water as negative control (NCW), were placed in the culture plate wells. Considering the immobility of the larvae as a positive anthelmintic effect, the results showed that in NCW treatments all larvae were mobile, while in PCI all 300 larvae were immobile. FCL produced a gradient of larval inactivation correlation (R2 0.996). The best-fit equation was y = -33.39ln(x) + 40.517, a logarithmic equation, which allowed the calculation of the Lethal Concentration (CL) of 3.44 µg CN- ml, or 80.0 mg of fresh cassava leaves per milliliter of water, with a performance equivalent to ivermectin. This concentration of free cyanide is compatible with the safe consumption of fresh leaves by live weight of sheep. The exact amount of cassava roots, leaves, or shoots, consumed to provide an effective dose for controlling H. contort should be established in vivo. Although phenolic compounds must also be present in the extract, the immobility was attributed to cyanogenic compounds since the correlation was proportional to the increase in the cyanide concentration. It can be concluded that the consumption of fresh cassava leaves has the potential as an anthelmintic agent to be evaluated in vivo by feeding sheep and goats. Local use could also add value to the production of fresh cassava leaves, with an average potential production of 2.5 tonnes ha-1, available throughout the year, with greater production at the beginning of cultivation and in the summer months. These leaves could be used after the roots harvesting or even after pruning for this purpose. Currently, this amount of good quality protein material remains without use in the field.
Prediction Role of Baseline Digital Substraction Angiography in GEP Neuroendocrine Liver Metastases Treated with TAE/ TACE
Authors: Li Xiaofen , Li Linjuan , Pu Jin , Suo Jiaojiao , Luo Xuefeng , You Xin , Liao Zhengyin , Cao Dan
Published: November 2021

Aim

Transarterial embolization (TAE) or transarterial chemoembolization (TACE) is an important treatment approach for unresectable liver metastatic gastroenteropancreatic neuroendocrine tumors (GEP-NETs). The prediction tool for therapeutic evaluation is still unclear. This study was performed to assess the prediction role of baseline digital substraction angiography (DSA) in synchronous liver metastatic GEP-NETs treated with TAE/ TACE.
Methods

Twenty-two patients with synchronous unresectable liver metastatic GEP-NETs (G1/2) and treated with TAE/ TACE were retrospectively enrolled. Clinical characteristics, baseline DSA and computed tomography (CT) information were collected.
Results

Totally, the overall response rate of TAE/ TACE on liver metastasis was 45.5%. The average baseline CT ratio (the density of the target lesion / the density of abdominal aorta during arterial phase) between responsive group and nonresponsive group were not statistically different (0.30±0.06 versus 0.36±0.11, P=0.149). Whereas, the average baseline DSA ratio (the density of target lesion / the density of liver background on DSA imaging before TAE/ TACE) of responsive group was significantly lower compared with that of nonresponsive group (0.57±0.13 versus 0.70±0.15, P=0.037). Patients with a DSA ratio ≤0.64 were more responsive to TAE/ TACE than those with a DSA ratio ༞0.64 (58.3% versus 30%). Univariate and multivariate analysis indicated that patients with lower hepatic tumor burden had longer PFS.
Conclusions

Baseline DSA ratio is a simple and potentially useful method to predict therapeutic effect of TAE/ TACE in liver metastases from GEP-NETs. And patients with lower hepatic tumor burden might indicate better prognosis. Prospective large-scale study is warranted.
A Promising Diagnostic Role of Immunohistochemical Expression of Insulin-Like Growth Factor II mRNA Binding Protein3 (IMP3) in Pancreatic Lesions Using Endoscopic Ultrasound –Guided –Fine Needle Aspiration (EUS-FNA) Cytology
Authors: Rashed Hayam , Wasfi Nora , Nasr Awatef , ElHendawy Ramy , Said Nelly Mohammed
Published: November 2021

Background: Poor prognosis and short survival of patients harboring pancreatic cancer emerge how advanced disease it is. In a trial to achieve the earliest and most accurate diagnosis to manage this progressive disease, we proposed that using endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) with an adjuvant diagnostic immunohistochemical marker would give better diagnostic results. IMP3 has gained recently wide attention, as many studies found that IMP3 has not only diagnostic but also prognostic role in different types of malignancies. Aim of the study: this prospective work is to assess the diagnostic role of EUS-FNA combined with the immunohistochemical expression of IMP3 on different benign and malignant pancreatic lesions. Material and Method: the included pancreatic lesions (n=140) were obtained by EUS-FNA technique and stained for IMP3 immunohistochemically. Paraffin blocks from patients who underwent excision (n=92) or core biopsies (n=48) were performed for confirming diagnosis. Results: the combined method for diagnosis showed that IMP3 was positive in 78.7%, 91.7%, 100% PAC, Mucinous neoplasm with high grade dysplasia, IPMN with high grade dysplasia, respectively, while almost all benign lesions showed negative IMP3. Also, this method showed sensitivity (78.26%), specificity (95.83%), and accuracy (84.3%). Conclusion: EUS-FNA cytology with IMP3 could be a reliable diagnostic tool especially for assessment of malignant pancreatic lesions.
Change and Stability in the Paternal Role Among Palestinian Fathers Living in Israel
Authors: Kashkoush Shada , Kassom Sereen , Gershy Naama
Published: November 2021

In the current study, we expand the understanding of paternal involvement in the Arab world and studied paternal involvement among Palestinian fathers living in Israel. To address cultural and sociopolitical contexts, we investigated the paternal role in relation to modernization processes characterizing Palestinian society in Israel (education, tradition, and religiosity). To capture the variance in the paternal role, we assessed it as a multifaceted construct involving three dimensions: direct childcare, household chores, and taking care of bureaucracy and finances. Sixty-eight Palestinian couples participated in the study. Participating parents separately completed a questionnaire assessing parenting role division. In addition, participating fathers completed questionnaires assessing paternal religiosity, and traditionality. Results showed that among the different involvement types, Palestinian fathers are most involved in home-related financial and bureaucratic tasks (i.e., outside tasks). Compared to bureaucracy and finances, paternal involvement in direct childcare tasks was lower, and involvement in routine housework was the lowest. Among the modernity variables, fathers’ tertiary education, but not religiosity or traditionality, predicted increased paternal involvement in childcare tasks and routine housework. The study results suggest the continuous prominence of traditional gender role division among Palestinian fathers living in Israel and indicate a slight change among fathers with higher education. The relative prominence of indirect forms of paternal involvement found in our study highlight the importance of evaluating paternal involvement as a multifaceted construct involving both direct and indirect care tasks in collectivistic and traditional societies.
Optimizing Non-Pharmaceutical Intervention Strategies Against COVID-19 Using Artificial Intelligence
Authors: Janko Vito , Reščič Nina , Vodopija Aljoša , Susič David , De Masi Carlo Maria , Tušar Tea , Gradisek Anton , Vandepitte Sophie , De Smedt Delphine , Javornik Jana , Gams Matjaz , Lustrek Mitja
Published: November 2021

One key task in the early fight against the COVID-19 pandemic was to plan non-pharmaceutical interventions to reduce the spread of the infection while limiting the burden on the society and economy. With more data on the pandemic being generated, it became possible to model both the infection trends and intervention costs, transforming the creation of an intervention plan into a computational optimization problem. This paper proposes a framework developed to help policy-makers plan the best combination of non-pharmaceutical interventions and to change them over time. We developed a hybrid machine-learning epidemiological model to forecast the infection trends, aggregated the socio-economic costs from literature and expert knowledge, and used a multi-objective optimization algorithm to find and evaluate various intervention plans. The framework is modular and easily adjustable to a real-world situation, it is trained and tested with data collected from almost all countries of the world, and its proposed intervention plans generally outperform those used in real life in terms of both the number of infections and intervention costs.
How is Social Media Used in the Context of Complementary and Alternative Medicine? A Scoping Review
Authors: Ng Jeremy Y. , Verhoeff Natasha , Steen Jeremy
Published: November 2021

Background

Despite the increased use of social media to share health-related information and the substantial impact that complementary and alternative medicine (CAM) can have on individuals’ health and wellbeing, currently, to our knowledge, there is no review that compiles research on how social media is used in the context of CAM. The objective of this study was to summarize the research on how social media is used in the context of CAM.
Methods

A scoping review was conducted to investigate how social media is used in the context of CAM, following Arksey and O’Malley’s five-stage methodological framework. MEDLINE, EMBASE, PsycINFO, AMED, and CINAHL databases were systematically searched, in addition to the Canadian Agency for Drugs and Technology in Health (CADTH) website. Eligible articles had to have investigated how at least one social media platform is used in the context of a single or multiple types of CAM treatments.
Results

Searches retrieved 1714 items following deduplication, of which 1687 titles and abstracts were eliminated, leaving 94 full-text articles to be considered. Of those, 65 were not eligible, leaving a total of 29 articles eligible for review. Four themes emerged from our analysis: 1) social media is used to share user/practitioner beliefs, attitudes, and experiences about CAM, 2) social media acts as a vehicle for the spread of misinformation about CAM, 3) there are unique challenges with social media research in the context of CAM, 4) social media is effective in delivering CAM-related therapy and information.
Conclusions

This scoping review is the first, to our knowledge, to provide a descriptive analysis of the literature regarding how social media is used in the context of CAM. In addition to social media being a useful tool to share user/practitioner beliefs, attitudes, and experiences about CAM, it has shown to be accessible, effective, and a viable option in delivering CAM therapies and information. Social media has also shown to spread a large amount of misleading and false information in the context of CAM. Additionally, this review highlights the challenges with conducting social media research in the context of CAM, particularly in collecting a representative sample.