bluuebunny/crossref_metadata_2025 huggingface dataset:
CapST: Leveraging Capsule Networks and Temporal Attention for Accurate Model Attribution in Deep-fake Videos
Authors: Ahmad Wasim , Peng Yan-Tsung , Chang Yuan-Hao , Ganfure Gaddisa Olani , Khan Sarwar
Published: January 2025

Deep-fake videos, generated through AI face-swapping techniques, have garnered considerable attention due to their potential for impactful impersonation attacks. While existing research primarily distinguishes real from fake videos, attributing a deep-fake to its specific generation model or encoder is crucial for forensic investigation, enabling precise source tracing and tailored countermeasures. This approach not only enhances detection accuracy by leveraging unique model-specific artifacts but also provides insights essential for developing proactive defenses against evolving deep-fake techniques. Addressing this gap, this paper investigates the model attribution problem for deep-fake videos using two datasets: Deepfakes from Different Models (DFDM) and GANGen-Detection, which comprise deep-fake videos and images generated by GAN models. We select only fake images from the GANGen-Detection dataset to align with the DFDM dataset, which specifies the goal of this study, focusing on model attribution rather than real/fake classification. This study formulates deep-fake model attribution as a multiclass classification task, introducing a novel Capsule-Spatial-Temporal (CapST) model that effectively integrates a modified VGG19 (utilizing only the first 26 out of 52 layers) for feature extraction, combined with Capsule Networks and a Spatio-Temporal attention mechanism. The Capsule module captures intricate feature hierarchies, enabling robust identification of deep-fake attributes, while a video-level fusion technique leverages temporal attention mechanisms to process concatenated feature vectors and capture temporal dependencies in deep-fake videos. By aggregating insights across frames, our model achieves a comprehensive understanding of video content, resulting in more precise predictions. Experimental results on the DFDM and GANGen-Detection datasets demonstrate the efficacy of CapST, achieving substantial improvements in accurately categorizing deep-fake videos over baseline models, all while demanding fewer computational resources.
Rerouting Planar Curves and Disjoint Paths
Authors: Ito Takehiro , Iwamasa Yuni , Kakimura Naonori , Kobayashi Yusuke , Maezawa Shun-Ichi , Nozaki Yuta , Okamoto Yoshio , Ozeki Kenta
Published: January 2025

In this paper, we consider a transformation of

\(k\)

disjoint paths in a graph. For a graph and a pair of

\(k\)

disjoint paths

\(\mathcal{P}\)

and

\(\mathcal{Q}\)

connecting the same set of terminal pairs, we aim to determine whether

\(\mathcal{P}\)

can be transformed to

\(\mathcal{Q}\)

by repeatedly replacing one path with another path so that the intermediates are also

\(k\)

disjoint paths. The problem is called
Disjoint Paths Reconfiguration
. We first show that
Disjoint Paths Reconfiguration
is

\(\mathsf{PSPACE}\)

-complete even when

\(k=2\)

. On the other hand, we prove that, when the graph is embedded on a plane and all paths in

\(\mathcal{P}\)

and

\(\mathcal{Q}\)

connect the boundaries of two faces,
Disjoint Paths Reconfiguration
can be solved in polynomial time. The algorithm is based on a topological characterization for rerouting curves on a plane using the algebraic intersection number. We also consider a transformation of disjoint

\(s\)

-

\(t\)

paths as a variant. We show that the disjoint

\(s\)

-

\(t\)

paths reconfiguration problem in planar graphs can be determined in polynomial time, while the problem is

\(\mathsf{PSPACE}\)

-complete in general.
Web 3.0-Enabled Microservice Re-Scheduling for Heterogenous Resources Co-Optimization in Metaverse-Integrated Edge Networks
Authors: Yang Yihong , Zhou Zhangbing , Shu Lei , Zhou Feng , Gaaloul Walid , Khan Arif Ali
Published: January 2025

The Web 3.0 and metaverse can empower intelligent application of Connected Autonomous Vehicles (CAVs). The adoption of edge computing can contribute to the low latency interaction between CAVs and the metaverse. Microservices are widely deployed on edge networks and the cloud nowadays. User's requests from CAVs are typically fulfilled through the composition of microservices, which may be hosted by contiguous edge nodes. Requests may differ on their required resources at runtime. Consequently, when requests are continuously injected into edge networks, the usage of heterogenous resources, including CPU, memory, and network bandwidth, may not be the same, or differ significantly, on certain edge nodes. This happens especially when burst requests are injected into the network to be satisfied concurrently. Therefore, the usage of heterogenous resources provided by edge nodes should be co-optimized through re-scheduling microservices. To address this challenge, this paper proposes a Web 3.0-enabled
M
icroservice
R
e-
S
cheduling approach (called
MRS
), which is a migration-based mechanism integrating a placement strategy. Specifically, we formulate the microservice re-scheduling task as a multi-objective and multi-constraint optimization problem, which can be solved through a penalty signal-integrated framework and an improved pointer network. Extensive experiments are conducted on two real-world datasets. Evaluation results show that our
MRS
performs better than the counterparts with improvements of at least 7.7%, 2.4% and 2.2% in terms of network throughput, latency and energy consumption.
Time Series Classification with Elasticity Using Augmented Path Signatures
Authors: Wang Chenyang , Luo Ling , Aickelin Uwe
Published: January 2025

We often compare time-dependent data elastically such that some compression or dilation along the time dimension can be ignored, for example, spatial trajectories of vehicles moving at different speeds or accelerometer data for exercises completed at variable rhythms. Traditionally this is possible via an alignment-based elastic distance measure, such as Dynamic Time Warping (DTW). We may also control the degree of allowable warping with warping constraints. However, these elastic distance measures are not easy to use in large scale time series classification, as they need to be evaluated pairwise and often cannot be directly converted into feature sets that we may use with arbitrary classifiers or combine with other features. In this research, we focus on the study of path signatures, a transformation with time warping invariance property, and how we may augment a time series to make its signature space representation reflect common warping constraints. We demonstrate that the comparing signatures is analogous to comparing time series with elastic distances, and that augmented signature features can serve as warping invariant or insensitive features in time series classification. Finally, we construct Multiple Path Signatures with Constraining Augmentations Classifier (MultiPSCA), a general-purpose minimal tuning time series classifier using augmented signatures, and show that it is able to beat existing best-performing elastic time series classification algorithms without per-dataset hyperparameter tuning.
Problematizing the sustainability of 5G/6G networks and devising alternative ways forward
Authors: Cano Cristina , March Hug
Published: January 2025

Mobile communications networks are increasingly advocated as enablers for environmental sustainability (“5G/6G for sustainability”) due to their potential induced effects towards green transitions. Despite this potential, their impact on sustainability is also acknowledged, and there are substantial research efforts to make these networks more sustainable by reducing their direct effects (“sustainable 5G/6G”). The sustainability of these networks is then seen as a trade-off between induced benefits and direct effects. However, we argue that there is an urgent need to critically problematize these two interrelated and entrenched visions around the intersection of sustainability and mobile networks. The former (“5G/6G for sustainability”) relies on highly speculative forecasts of the potential of mobile networks to be a critical enabler of the green transitions and takes limited account of negative induced effects, while the latter (”sustainable 5G/6G”) focuses on energy efficiency metrics, obscuring potential increasing absolute energy demand and other environmental dimensions, involving elements challenging to compare. In this article, we call for more responsible mobile network development and a deeper analysis of its potential effects on sustainable transitions.
A Hybrid Approach for Localisation of Sensor Nodes in Remote Locations
Authors: Hada Rupendra Pratap Singh , Srivastava Abhishek
Published: January 2025

A Wireless Sensor Network (WSN) is a network of sensor nodes using low-power wireless technology to collect data in a region of interest (ROI). Due to their low energy, locating sensor nodes in large outdoor areas is challenging, which precludes GPS integration. WSNs typically comprise a small number of beacon nodes (BN) whose locations are known in advance, with most nodes deployed at unknown coordinates within the ROI. Endeavours to determine the locations of such unknown WSN nodes are largely based on the impractical assumption that every unknown node (UN) is within the communication range of BNs. Subsequently, these approaches utilise at least two BNs to determine the position of one UN. The Received Signal Strength Indicator (RSSI) or Angle of Arrival (AoA) values of the signals from the BNs form the basis for such localisation. This paper suggests an iterative hybrid approach incorporating AoA and RSSI techniques, achieving accurate localisation with just one BN. The iterative method gradually covers the region, avoiding the unrealistic assumption of having all UNs within range. It also presents an innovative use of a unipolar stepper motor for AoA measurements. Experiments in a simulated environment and a real-world prototype validate the approach’s effectiveness.
Development and Functions of MAIT Cells
Authors: Salou Marion , Paiva Rafael A. , Lantz Olivier
Published: January 2025

Mucosal-associated invariant T (MAIT) cells are evolutionarily conserved T cells that recognize microbial metabolites. They are abundant in humans and conserved during mammalian evolution, which suggests that they have important nonredundant functions. In this article, we discuss the evolutionary conservation of MAIT cells and describe their original developmental process. MAIT cells exert a wide variety of effector functions, from killing infected cells and promoting inflammation to repairing tissues. We provide insights into these functions and discuss how they result from the context of stimulation encountered by MAIT cells in different tissues and pathological settings. We describe how MAIT cell numbers and features are modified in disease states, focusing mainly on in vivo models. Lastly, we discuss emerging strategies to manipulate MAIT cells for therapeutic purposes.
Insights Into Genetic Variations of the OCT1 Gene in Metformin Poor Responders Among Bangladeshi Type 2 Diabetic Patients
Authors: Begum Rokeya , Das Arindita , Alam Md. Jahangir , Sultana Gazi Nurun Nahar
Published: January 2025

Metformin is the most widely prescribed drug for the treatment of Type 2 diabetes mellitus (T2DM), but its response varies from person to person. This study aims to analyze the complete mutation spectrum of the OCT1 gene in metformin poor responders and to explore the potential pathogenic effects of the identified mutations. Clinical features of 56 Bangladeshi T2DM patients (who showed altered response to metformin) were analyzed, and genomic DNA was extracted from their blood samples. Subsequently, the entire exons (1–11), along with flanking introns of the OCT1 gene were amplified and sequenced. Molecular consequences of the identified mutations on OCT1 protein activity were determined through in silico analyses. In this study, 29 mutations of the OCT1 gene were identified; among which 5 mutations (c.412‐86G>T, c.970G>C, c.1386‐3088_1386‐3083delGAATCA, c.1498+66G>T, and c.1653C>A) were novel. It was found that nsSNPs c.181C>T, c.1022C>T, c.493G>T, c.1207A>G, and c.970G>C (novel) as well as frameshift deletions have potential deleterious effects on OCT1 protein stability and function. Some of these mutations also cause alternative splicing, as per the HSF tool. In addition, alteration of interatomic bonding in the OCT1 protein due to two high‐risk mutations (c.181C>T and c.1022C>T) was found from web‐based analysis. The mutations, as mentioned earlier, are the most probable causative factor of decreased metformin effectiveness and adverse side effects in T2DM patients who are poor responders. Understanding the OCT1 gene variations of patients can help tailor treatment strategies for optimal metformin response or identify alternative medications.
Current Status of the Propagation of Basil in Aquaponic Systems: A Literature Review
Authors: Hussain Aya S. , Brown Paul B.
Published: January 2025

Basil (Ocimum sp.) is a commercially important herb that has been coupled with several aquatic organisms in aquaponic systems. The goal of this literature review was to aggregate the current knowledge on the status of basil production in aquaponic systems by identifying the different aquatic organisms cultured with basil and hydroponic subsystems cultured with basil species/varieties and address research gaps. Of the 100 reviewed publications, about 90% of the reviewed publications used sweet basil (Ocimum basilicum L.) and only three publications used a different basil species; holy basil (Ocimum tenuiflorum), lime basil (Ocimum americanum), or lemon basil, (Ocimum africanum). Of the publications that used sweet basil, Genovese was the most commonly used variety (21 articles), followed by Italian large leaf (6 articles) and purple ruffles (4 articles) varieties. Between the reviewed publications, 38.7% used deep water culture (DWC), 31.1% used media bed (MB), and 17.9% used nutrient film technique (NFT) to grow basil. Tilapia was the most commonly cultured species with basil in aquaponic systems (44%), followed by catfish (14%) and carp (9%). The amount of feed for tilapia Oreochromis sp. cultured as a function of grow space area ranged between 20.3 and 81.6 g feed/m2/day. Values ranged between 29.2 and 68.9 g feed/m2/day while culturing Pangasius sp., 20–25 g feed/m2/day while culturing catfish (Ictalurus sp.), and 4.4–16.9 g feed/m2/day while culturing carp (Cyprinus sp.). The variability in the fish feed‐to‐plant ratio suggests a need for establishing a recommendation for a species‐specific optimal feed input that supplies sufficient nutrients for basil. The current review suggests further investigations comparing different basil varieties, cultivating different basil cultivars with different fish or crustacean species, using alternative hydroponic types, and evaluating feed inputs for establishing a recommendation for species‐specific optimal conditions in aquaponic systems.
Identification of Novel lncRNAs Related to Colorectal Cancer Through Bioinformatics Analysis
Authors: Heidari Razieh , Assadollahi Vahideh , Marashi Seyedeh Negar , Elahian Fatemeh , Mirzaei Seyed Abbas
Published: January 2025

Long noncoding RNA (lncRNA) plays a critical role in cancer cell proliferation, invasion, metastasis, and chemoresistance. The current study introduces novel lncRNAs in colorectal cancer (CRC) through bioinformatics analysis. GSE134834 CRC‐related microarray of Gene Expression Omnibus (GEO) was analyzed to identify differentially expressed genes (DEGs) in CRC samples against normal samples. Analysis revealed 6763 DEGs (p < 0.05 and |log fold change (FC)| ≥ 0.5) that include differentially expressed mRNA (DEmRNA) and differentially expressed long noncoding RNA (DElncRNA). Novel lncRNAs were identified, and to better understand the biological function of the identified lncRNAs, gene modules were constructed using weighted gene coexpression network analysis (WGCNA), and finally, two modules for lncRNAs were obtained. The coexpression modules with these lncRNAs were subjected to enrichment analysis in FunRich software to predict their functions through their coexpressed genes. Gene ontology results of modules related to novel lncRNA revealed they significantly enriched the cellular pathways regulation in cancer. The protein–protein interaction (PPI) network of novel lncRNAs‐related modules was constructed using Search Tool for the Retrieval of Interacting Genes (STRING) and visualized using the Cytoscape software. Hub genes were screened from the PPI network by the CytoHubba plug‐in of Cytoscape. The hub genes were MRTO4, CDK1, CDC20, RPF2, NOP58, NIFK, GTPBP4, BUB1, BUB1B, and BOP1 for the lightpink4 module and BYSL, RPS23 (ribosomal protein S23), RSL1D1 (ribosomal L1 domain containing 1), NAT10, NOP14, GNL2, MRPS12, NOL6 (nucleolar protein 6), IMP4, and RRP12 (ribosomal RNA processing 12 homolog) for the pink module. The expression levels of the top DEmRNA and module hub genes in CRC were validated using the Gene Expression Profiling Interactive Analysis (GEPIA) database. Generally, our findings offer crucial insight into the hub genes and novel lncRNAs in the development of CRC by bioinformatics analysis, information that may prove useful in the identification of new biomarkers and treatment targets in CRC; however, more experimental investigation is required to validate the findings of the present study.
Sulbactam–Durlobactam: A Novel Antibiotic Combination for the Treatment of Acinetobacter baumannii–Calcoaceticus Complex (ABC) Hospital‐Acquired Bacterial Pneumonia and Ventilator‐Associated Bacterial Pneumonia
Authors: Kabbara Wissam K. , Sadek Elina , Mansour Hanine
Published: January 2025

Purpose: To evaluate the pharmacology, pharmacokinetics, pharmacodynamics, antimicrobial activity, efficacy, safety, and the regulatory status of sulbactam–durlobactam.

Summary: Sulbactam–durlobactam is a recently approved antimicrobial combination of two β‐lactamase inhibitors for the treatment of hospital‐acquired bacterial pneumonia (HABP) and ventilator‐associated bacterial pneumonia (VABP) associated with Acinetobacter baumannii–calcoaceticus complex (ABC) in patients 18 years and older. Sulbactam is a direct antibacterial activity with high susceptibility to A. baumannii species. Durlobactam, diazabicyclooctane β‐lactamase inhibitors possesses a broad‐spectrum activity against Ambler class A, C, and D serine β‐lactamases. This combination has been studied to overcome resistance to ABC species. Data were obtained from in vitro and preclinical studies as well as phase I, II, and III clinical studies published in English between 200t0 and January 2023. A phase II trial showed similar tolerability and pharmacokinetics parameters of sulbactam–durlobactam in patients with urinary tract infections to placebo. However, no ABC infections were included in the trial. ATTACK, a phase III clinical trial of sulbactam–durlobactam, studied the safety and efficacy of sulbactam–durlobactam in patients with ABC HABP/VABP and showed its noninferiority to colistin. Reported adverse events include anemia, elevated liver enzymes, hyperkalemia, headache, diarrhea, nausea, urticaria, and vascular pain. Sulbactam–durlobactam is a new β‐lactamase inhibitors combination active against MDR Gram‐negative bacteria including ABC. It is currently approved for the treatment of HABP/VABP caused by susceptible ABC strains.
Coexistence of T‐Cell Lymphoblastic Lymphoma and Ichthyosis Vulgaris: A Case Report
Authors: Kamış Şule Çalışkan , Yağcı Begül
Published: January 2025

Ichthyosis vulgaris (IV) is an inherited disorder characterized by the scaling of the skin. It is caused by mutations in the filaggrin gene. IV is a reactive skin manifestation that may be associated with malignant hematological disease. Its association with neoplastic diseases such as Hodgkin lymphoma, anaplastic large‐cell lymphoma, and mycosis fungoides has been reported. T‐cell non‐Hodgkin lymphoma (T‐NHL) with ichthyosis has been rarely reported in the literature. Here, we report a case of T‐cell lymphoma with congenital IV caused by a desmoglein 1 (DSG1) gene mutation associated with hyper‐IgE syndrome (HIES). A 7‐year‐old male patient with a diagnosis of congenital IV had a biopsy performed at an external center due to multiple lymphadenopathies, which revealed T‐cell lymphoblastic lymphoma. A homozygous variant in the DSG1 gene was detected through whole‐exome sequencing. The diagnosis of HIES was confirmed through clinical evaluation, including elevated serum IgE levels and associated symptoms. Skin findings, growth retardation, and HIES overlap with Online Mendelian Inheritance in Man (OMIM) #615508, and parental carrier status was confirmed. The association between ichthyosis and lymphoma was determined based on the presence of lymphoma in a patient with congenital ichthyosis and the identification of a genetic mutation in DSG1. In conclusion, the coexistence of lymphoma and IV is rare. The mechanisms of their formation are different, and they can occur independently. Rare genetic syndromes or inherited diseases can cause different health problems, such as lymphoma and ichthyosis, to occur together.
Handling Multiple‐Fuel Options in Economic Dispatch of Thermal Power Plants Through a Tight Model Applying Indicator Variables
Authors: Sharifzadeh Hossein
Published: January 2025

Thermal power plants play a central role in present power systems because of their high efficiency, fast startup capability, and flexibility to integrate the variability of renewable generations. These thermal units can utilize various fuels, including coal, natural gas, and oil, which enhances both the economic performance and security of the overall energy system. Representing the fuel cost functions of these units with multiple fuels (MFs) as binary decisions involves adding binary variables to the economic dispatch (ED) problem. The inclusion of these binary variables and nonlinear cost functions results in a complex NP‐hard mixed‐integer nonlinear programming (MINLP). This paper provides another perspective on the ED, where indicator variables represent the MF options and determine which cost functions should be set to zero. Based on this perspective, the paper builds a tight model to handle the indicator variables and solve the MINLP ED. Moreover, the paper introduces an iterative solution method with a bound‐tightening technique to speed up the solution process. We conducted experimental studies using eight ED case studies with MF options involving up to 1280 generating units. The optimal costs obtained from these case studies demonstrate the effectiveness of the tight model and the iterative solution method for solving the MINLP ED problem. Furthermore, the proposed approach generally outperforms earlier algorithms in terms of solution quality and robustness. Finally, the tight model can speed up the solution process by 18%–45% compared with the standard formulation in the adopted case studies.
Enhanced Recovery of Apple Pomace Phenolic Compounds: Optimizing Subcritical Water Extraction
Authors: Derakhshan Mahsa , Elhami Rad Amir Hossein , Javanmard Dakheli Majid , Sharayei Parvin , Armin Mohammad
Published: January 2025

This study was aimed at optimizing the extraction process of phenolic compounds, particularly antioxidants and antimicrobial agents, from apple pomace using the subcritical water extraction method. The Box–Behnken experimental design was utilized to ascertain the optimal extraction conditions, focusing on maximizing yield, phenolic compound content, and antioxidant activity. Three independent variables were investigated: extraction temperature (120°C, 140°C, and 160°C), extraction time (20, 30, and 40 min), and water‐to‐apple pomace ratio (1:20, 1:40, and 1:60 g/mL). The optimized subcritical water extraction process yielded a significantly higher extraction efficiency (18.05%), total phenolic content (1341.11 mg/100 g), and 2,2‐diphenyl‐1‐picrylhydrazyl (DPPH) scavenging capacity (92.39%) compared to the conventional maceration method. The experimental results aligned well with the predicted values obtained from the Box–Behnken model. The antimicrobial properties of the optimized extract were assessed against Staphylococcus aureus, Escherichia coli, and Aspergillus niger through the serial dilution method. The extract at a concentration of 30 mg/100 mL exhibited superior antifungal and antibacterial properties compared to potassium sorbate (10 mg/100 mL). This research demonstrates the potential of subcritical water extraction as a sustainable and efficient method for extracting phenolic compounds from apple pomace, offering a promising alternative to conventional methods and contributing to the valorization of agricultural waste.
Neptunea cumingii Extract Inhibits Adipogenesis and Stimulates Browning of Adipocytes in 3T3‐L1 Preadipocytes
Authors: Dayarathne Lakshi A. , Ko Seok-Chun , Yim Mi-Jin , Lee Jeong Min , Kim Ji-Yul , Oh Gun-Woo , Lee Dae-Sung , Jung Won-Kyo , Lee Sei-Jung , Je Jae-Young
Published: January 2025

This study investigates the potential antiobesity effects of Neptunea cumingii extract (NCE). Our findings illustrate that NCE effectively reduces lipid accumulation and triglyceride content, while simultaneously increasing free glycerol release. The reduction in lipid accumulation and induction of lipolysis were evidenced by the downregulation of lipogenesis proteins, such as fatty acid synthase and lipoprotein lipase, and the upregulation of hormone‐sensitive lipase expression. Furthermore, the downregulation of adipogenic transcription factors, including peroxisome proliferator–activated receptor gamma, CCAAT/enhancer‐binding protein α, and sterol regulatory element‐binding protein 1, indicates the inhibition of adipocyte differentiation. Additionally, NCE treatment induced brown adipocyte phenotype by upregulating brown adipose tissue–specific proteins, such as uncoupling protein 1 and peroxisome proliferator–activated receptor‐gamma coactivator 1α. Moreover, NCE led to the phosphorylation of AMPK, the master regulator of energy homeostasis. Pharmacological inhibition of AMPK using an AMPK inhibitor (Compound C) attenuated the lipogenesis inhibitory effect of NCE and reduced lipolysis and adipocyte browning. This suggests that AMPK activation is involved in these processes. GC–MS analysis reveals that NCE primarily consists of cholest‐5‐en‐3‐ol (27.15%) along with an array of fatty acids which possess favorable antiobesity properties. Collectively, these results highlight the potential of NCE as a lipid‐lowering agent for the intervention of obesity.
Recovery Method of Continuous Missing Data in the Bridge Monitoring System Using SVMD‐Assisted TCN–MHA–BiGRU
Authors: Xin Jingzhou , Mo Xingchen , Jiang Yan , Tang Qizhi , Zhang Hong , Zhou Jianting
Published: January 2025

Due to the influence of complex service environments, the bridge health monitoring system (BHMS) has to face issues such as sensor failures and power outages of data acquisition systems, leading to frequent occurrences of data missing events including continuous and discrete data missing. By comparison, the continuous data missing can cover up the time‐series characteristic and make the corresponding recovery present a greater difficulty, especially for the data with a large loss rate or complicated features. To this end, this paper develops a novel signal recovery method based on the combination of successive variational mode decomposition (SVMD) and TCN–MHA–BiGRU, which is the hybrid of temporal convolutional networks (TCNs), multihead attention (MHA), and bidirectional gated recurrent unit (BiGRU). In this method, SVMD with high reliability and strong robustness is initially employed to decompose the original signal into multiple stable and regular subseries. Then, TCN–MHA–BiGRU incorporating the concept of “extraction‐weighting‐description of crucial features” is designed for the independent recovery of each subseries, with the ultimate recovery result derived through the linear superposition of all individual recoveries. This method not only can effectively extract the data time‐frequency characteristics (e.g., nonstationarity) but also can accurately capture the data time‐series characteristics (e.g., linear and nonlinear dependences) within the data. The case study and the subsequent applicability analysis grounded in the monitoring data from BHMS are employed to comprehensively evaluate the effectiveness of the proposed method. The results indicate that this method outperforms compared methods for the recovery of continuous missing data with different missing rates.
Molecular and Serological Investigation of Equine Herpesvirus Type 1 (EHV‐1) and Type 4 (EHV‐4) in Horses In Ibagué, Tolima
Authors: Petano-Duque Julieth Michel , Urueña-Martinez Edwin , Cabezas-Callejas Laura Liliana , Perilla-Amaya Jorge , Rueda-García Valentina , Rondón-Barragán Iang Schroniltgen , Lopera-Vásquez Ricaurte
Published: January 2025

EHV‐1 is one of the most prevalent viral pathogens in horses; however, its prevalence is not well defined by cross‐reactions of serological tests. Thus, this study aims to determine EHV‐1/‐4 prevalence in Colombian creole horses from Ibagué, Tolima, using molecular techniques, as well as to determine possible risk factors associated with viral infection. A cross‐sectional study was carried out in 110 equines blood, serum, and semen samples from Ibagué, Tolima. Antibodies against EHV‐1/‐4 were determined through indirect ELISA. EHV‐1 was detected by amplifying the glycoprotein H gene through heminested PCR, and risk factors were calculated with chi‐square, odds ratio, and fisher test. EHV‐1/‐4 antibodies were found in 11.8% of the horses. Moreover, the presence of EHV‐1 and EHV‐4 was determined in blood, serum, and semen of healthy clinical equines, with a prevalence infection in horses of 43.36% for EHV‐1 and 2.7% for EHV‐4. Sex, age, births number, abortions, natural breeding, and artificial insemination did not show significance as risk factors. This study determined a high prevalence of EHV‐1 and low prevalence of EHV‐4 in horses from Ibagué, Tolima. Furthermore, the possibility of finding the infectious agent in blood, serum, and semen was demonstrated. We recommend the use of blood and serum samples for virus detection and the development of new studies to assess EHV‐1 infection feasibility in venereal transmissions.
An Immune Subtype Classification System Enables the Development of Strategies to Predict and Enhance Immunotherapy Responses in Colorectal Cancer
Authors: Li Dingchang , Liu Xianqiang , Gao Wenxing , Zhao Wen , Ji Shuaifei , Wang Sizhe , Yang Jinran , Li Dingling , Chang Zhengyao , Chen Yi , Sun Xu , Zhou Jingcheng , Jiao Yanan , Du Xiaohui , Dong Guanglong
Published: January 2025

Colorectal cancer (CRC) is the second leading cause of cancer-related mortality globally. While immunotherapeutic approaches are effective in a subset of CRC patients, the majority of CRC cases receive limited benefits from immunotherapy. This study developed an immune subtype classification system based on diverse immune cells and pathways. A model constructed through machine learning based on immune subtypes could accurately predict the sensitivity of CRC patients to immunotherapy. Validation of this model across public datasets and clinical samples confirmed its high precision and reliability. Furthermore, drug screening based on the immune subtypes identified the IGF1R inhibitor I-OMe-AG-538 (AG-538) as a potent enhancer of antitumor immunity. Mechanistic investigations revealed that AG-538 induced reactive oxygen species (ROS)-dependent DNA damage and downregulated the expression of multiple repair genes, triggering cGAS/STING-mediated type I IFN signaling within tumor cells. This signaling cascade increased tumor immunogenicity and refined the tumor immune microenvironment, thereby enhancing efficacy of immune checkpoint blockade treatment. In summary, these findings present a predictive model for immune response and highlight the potential of AG-538 combined with anti-PD1 antibodies as a chemoimmunotherapeutic strategy.
Phase I Clinical Trial of High Doses of Seleno-L-methionine in Combination with Axitinib in Patients with Previously Treated Metastatic Clear Cell Renal Cell Carcinoma
Authors: Zakharia Yousef , Reis Ryan J. , Kroll Matthew R. , Rataan Aseel O. , Manchkanti Srija , Rahim Bilal , Garje Rohan , Swami Umang , Mott Sarah L. , Zamba K.D. , Sieren Jessica C. , Salem Aliasger K. , Rustum Youcef
Published: January 2025

Background: Data in clear cell renal cell carcinoma (ccRCC) xenografts defined the seleno-L-methionine (SLM) dose and the plasma selenium concentrations associated with the enhancement of HIF1α/2α degradation, stabilization of tumor vasculature, enhanced drug delivery, and efficacy of axitinib. The data provided the rationale for the development of this phase I clinical trial of SLM and axitinib in advanced or metastatic relapsed ccRCC. Patients and Methods: Patients were ≥18 years with histologically and radiologically confirmed advanced or metastatic ccRCC who had received at least one prior systemic therapy, which could include axitinib (last dose ≥6 months prior to enrollment). Escalating dose levels of SLM (2500, 3000 and 4000 μg) were administered orally twice daily for 14 days, then once daily concurrently with axitinib 5 mg twice daily using a 3+3 design in Phase I. Patients were treated at the 4000 μg dose level in the expansion cohort to obtain preliminary estimates of efficacy. Results: No dose limiting toxicities occurred at the 4000 μg SLM dose level. Among the 27 patients treated with 4000 μg of SLM, the overall response rate was 55.6%, median duration of response was 18.4 months, median progression-free survival was 14.8 months, and median overall survival was 19.6 months. Preliminary results have shown that plasma selenium concentrations, inhibition of TGF-β1 and stabilization of tumor vasculature by SLM are time dependent. Conclusions: SLM (4000 μg) in sequential combination with axitinib is well tolerated with encouraging efficacy.
Table S7 from Potential Synergistic Effect between Niraparib and Statins in Ovarian Cancer Clinical Trials
Authors: Zhang Hailei , Rutkowska Anna , González-Martín Antonio , Mirza Mansoor R. , Monk Bradley J. , Vergote Ignace , Pothuri Bhavana , Graybill Whitney A. Spannuth , Goessel Carsten , Barbash Olena , Bergamini Giovanna , Feng Bin
Published: January 2025

NOVA patient characteristics and baseline demographics
Table S2 from Potential Synergistic Effect between Niraparib and Statins in Ovarian Cancer Clinical Trials
Authors: Zhang Hailei , Rutkowska Anna , González-Martín Antonio , Mirza Mansoor R. , Monk Bradley J. , Vergote Ignace , Pothuri Bhavana , Graybill Whitney A. Spannuth , Goessel Carsten , Barbash Olena , Bergamini Giovanna , Feng Bin
Published: January 2025

Results of analysis from the PRIMA clinical trials
Table S1 from Potential Synergistic Effect between Niraparib and Statins in Ovarian Cancer Clinical Trials
Authors: Zhang Hailei , Rutkowska Anna , González-Martín Antonio , Mirza Mansoor R. , Monk Bradley J. , Vergote Ignace , Pothuri Bhavana , Graybill Whitney A. Spannuth , Goessel Carsten , Barbash Olena , Bergamini Giovanna , Feng Bin
Published: January 2025

Patient characteristics for PRIMA/NOVA/QUADRA – statins concomitant
Table 1 from Potential Synergistic Effect between Niraparib and Statins in Ovarian Cancer Clinical Trials
Authors: Zhang Hailei , Rutkowska Anna , González-Martín Antonio , Mirza Mansoor R. , Monk Bradley J. , Vergote Ignace , Pothuri Bhavana , Graybill Whitney A. Spannuth , Goessel Carsten , Barbash Olena , Bergamini Giovanna , Feng Bin
Published: January 2025

Number of patients with and without statin concomitant in the PRIMA, NOVA, and QUADRA clinical trials
Figure 3 from Potential Synergistic Effect between Niraparib and Statins in Ovarian Cancer Clinical Trials
Authors: Zhang Hailei , Rutkowska Anna , González-Martín Antonio , Mirza Mansoor R. , Monk Bradley J. , Vergote Ignace , Pothuri Bhavana , Graybill Whitney A. Spannuth , Goessel Carsten , Barbash Olena , Bergamini Giovanna , Feng Bin
Published: January 2025

Retrospective analysis of PRIMA clinical trial in the HRp group. A, Kaplan–Meier estimation of PFS comparing patients classified as HRp treated with niraparib (n = 33) and placebo (n = 18) in the cohort with statin concomitant; stratified analysis with three randomization factors (response to first platinum, HRd status, and neoadjuvant usage); mPFS, HR, and log-rank test P value are reported. B, Kaplan–Meier estimation of PFS comparing patients treated with niraparib (n = 135) and placebo (n = 61) in the cohort without statin concomitant. C, Kaplan–Meier estimation of PFS comparing all four arms (the placebo without statins was the reference arm for comparison to the other three arms: niraparib, niraparib + statin, and placebo + statin). D, Kaplan–Meier estimation of PFS comparing niraparib to niraparib + statin arm.
Figure 2 from Potential Synergistic Effect between Niraparib and Statins in Ovarian Cancer Clinical Trials
Authors: Zhang Hailei , Rutkowska Anna , González-Martín Antonio , Mirza Mansoor R. , Monk Bradley J. , Vergote Ignace , Pothuri Bhavana , Graybill Whitney A. Spannuth , Goessel Carsten , Barbash Olena , Bergamini Giovanna , Feng Bin
Published: January 2025

Retrospective analysis of the PRIMA clinical trial in the HRd group. A, Kaplan–Meier estimation of PFS comparing patients classified as HRd treated with niraparib (n = 49) and placebo (n = 29) in the cohort with statin concomitant; stratified analysis with three randomization factors (response to first platinum, HRd, status, and neoadjuvant usage); mPFS, HR, and log-rank test P value are reported. B, Kaplan–Meier estimation of PFS comparing patients treated with niraparib (n = 196) and placebo (n = 96) in the cohort without statin concomitant. C, Kaplan–Meier estimation of PFS comparing all four arms (the placebo without statins was the reference arm for comparison to the other three arms: niraparib, niraparib + statin, and placebo + statin). D, Kaplan–Meier estimation of PFS comparing niraparib to niraparib + statin arm.
Figure 1 from Potential Synergistic Effect between Niraparib and Statins in Ovarian Cancer Clinical Trials
Authors: Zhang Hailei , Rutkowska Anna , González-Martín Antonio , Mirza Mansoor R. , Monk Bradley J. , Vergote Ignace , Pothuri Bhavana , Graybill Whitney A. Spannuth , Goessel Carsten , Barbash Olena , Bergamini Giovanna , Feng Bin
Published: January 2025

Retrospective analysis of PRIMA clinical trial–the interaction between niraparib and statin is significant. A, Kaplan–Meier estimation of PFS comparing patients treated with niraparib (n = 92) and placebo (n = 51) in the cohort with statin concomitant; stratified analysis with three randomization factors (response to first platinum, HRd status, and neoadjuvant usage); mPFS, HR, and log-rank test P value are reported. B, Kaplan–Meier estimation of PFS comparing patients treated with niraparib (n = 392) and placebo (n = 193) in the cohort without statin concomitant. C, Kaplan–Meier estimation of PFS comparing all four arms (the placebo without statins was the reference arm for comparison to the other three arms: niraparib, niraparib + statin, and placebo + statin). Statin and niraparib showed the synergistic combination effect (significant interaction) in this retrospective analysis. No significant differences in baseline characteristics (e.g., age and weight) across groups were observed (Supplementary Table S3). D, Kaplan–Meier estimation of PFS comparing niraparib to niraparib + statin arm.
First intrapartum sonographic diagnosis of fetal hypoxic ischemic encephalopathy (FHIE)
Authors: Dall'Asta Andrea , Melito Chiara , Petrolini Chiara , Perrone Serafina , Ghi Tullio
Published: January 2025

Novel Insights
In presence of cardiotocographic features suspected for hypoxic insult, intrapartum ultrasound in the hands of experienced operators can demonstrate cerebral edema as an indirect sign of fetal hypoxia affecting the fetal CNS and exclude non-hypoxic conditions potentially leading to abnormalities of the fetal heart rate.
Introduction
Hypoxic-ischemic encephalopathy is a syndrome involving the fetal central nervous system as the result of a perinatal hypoxic-ischemic injury. To date, transfontanellar ultrasound represents the first line exam in neonates with clinical suspicion of HIE as it allows to show features indicating acute hypoxic injury and exclude potential non-hypoxic determinants of HIE, however there is no report concerning the sonographic assessment of the brain during labor. In this clinical case we report the intrapartum sonographic evaluation of the fetal brain as a tool for the differential diagnosis of cardiotocographic abnormalities.
Case Presentation
A 42-year-old para 2 woman underwent labor induction at 37+3 weeks due to preeclampsia. On admission cardiotocography was normal, as was umbilical artery Doppler. De novo changes of the CTG pattern prior to the onset of labor raised the suspicion of a supervening fetal cerebral insult leading to the decision to expedite delivery by emergency cesarean. During the preparation for delivery, intrapartum ultrasound allowed to demonstrate fetal cerebral edema representing an early sign of superimposed intrapartum acute hypoxic insult in the context of chronic antepartum hypoxia and exclude non-hypoxic conditions of cardiotocographic abnormalities.
Conclusion
This is the first intrapartum sonographic demonstration of imaging findings consistent with cerebral edema in a fetus at risk for in utero hypoxia, hence suspected for fetal hypoxic ischemic encephalopathy (FHIE). Intrapartum ultrasound can assist clinicians in the differential diagnosis of intrapartum fetal hypoxia as long as it does not delay any interventions required to prevent hypoxic injury.
Judeus libaneses em São Paulo: memória, identidade e perspectiva de musealização
Authors: Bialski Adriana Abuhab
Published: January 2025

The present work proposes to share some initial reflections raised by the ongoing doctoral research, provisionally entitled Jews of the Middle East in São Paulo: perspectives of musealization for the legacy of Lebanese immigrants. This study aims to rescue, deepen, and give visibility to the history and memory of Jewish families from Lebanon, responsible for the formation of an organized community in São Paulo at the beginning of the twentieth century. To this end, concepts of the New Museology and notions of community and ethnographic museums are mobilized, which support the development of a musealization proposal for the material and intangible heritage of the group in focus. Thus, it is intended, on the one hand, to value the culture of these immigrants and contribute to the safeguarding of their legacy, and, on the other hand, in theoretical terms, to collaborate to fill a gap in the interface between Jewish and museum studies.
Atributos divinos: a tese maimonideana e a crítica de Hasdai Crescas
Authors: Cavalcanti Diogo de Araujo
Published: January 2025

The philosophical discussion about the divine attributes was important both to Moses ben Maimon, or Maimonides (1135/1138–1204) as to Hasdai ben Judah, also known as Crescas (1340–1410/1411). More than a polemic of medieval Jewish and Arabic ontotheology, it is a key issue, both from Maimonides’ perspective and that of his opponent. At the center of the debate is the Avicenian concept of Necessary Being, derived from the Aristotelian Prime Mover, postulated by Maimonides and rejected by Crescas.
Effects of feed nutrients on growth, development and the deposition of protein and fat in Tenebrio molitor larvae
Authors: Tamim B. , Salter A. , Parr T. , Brameld J.
Published: January 2025

An understanding of the impact of dietary nutritional composition on growth, development and composition of Tenebrio molitor larvae (mealworms) could help optimise production systems. Replicate containers of mealworms fed for 24 days on synthetic cellulose-based feeds containing different combinations of protein (casein, Cas), lipid (wheat germ oil, WGO), carbohydrate (glucose) and a mineral/vitamin premix (MV) were compared to a control diet of wheat bran (WB). Mealworms fed only cellulose (C) ceased to grow after 10 days, and did not pupate. Addition of casein alone did not restore growth but did induce pupation (much slower than in WB-fed worms). Mealworms fed C+Cas-based diets showed a marked increase in the relative proportion of body protein to fat, compared to those fed wheat bran. The addition of MV to the C+Cas diet restored growth and pupation, though not to the same level as WB. MV-fed worms maintained a significantly increased protein/fat composition. The further inclusion of WGO or WGO + glucose further increased growth, whilst WGO + glucose reduced pupation. Overall, the highest yield of protein (per container) was seen in the C+Cas+MV+WGO-fed mealworms, which was 50% higher than in the WB group (largely due to the decreased pupation rate). Furthermore, the lipid yield was 50% lower than in WB-fed mealworms. By contrast, the addition of glucose to this diet maintained a high protein yield but increased the lipid yield to similar levels as seen in WB-fed mealworms, with an associated significant increase in the relative proportion of the polyunsaturated fatty acids (PUFA), linoleic and α-linolenic acids. The results indicate that sources of protein, lipid, minerals and multivitamins are all required to maximize protein whilst decreasing lipid deposition in mealworms. However, the addition of glucose (and presumably other digestible carbohydrates) increased lipid deposition and specifically the PUFA content.
The Meaning of the Son of God
Authors: Durie Mark
Published: January 2025

The New Testament Greek expression ho huios tou theou ‘the Son of God’ is frequently used to refer to Jesus in the New Testament and is central to Christian understandings of Jesus’ identity. It has a complex meaning, grounded in the different ways in which it is used in the New Testament to refer to Jesus.

A crisis emerged in recent decades in Protestant Bible translation over how divine familial terms such as Son and Father are to be translated in Muslim contexts. A behaviourist, anti-cognitivist understanding of meaning was incorporated into Eugene Nida’s influential concept of dynamic equivalence and this was one of the key factors that triggered this crisis. A defence is offered here of retaining divine familial terms in Bible translations, drawing upon on an explication of the meaning of ho huios tou theou using an nsm Minimal Languages approach.
Monsters, Victims and Rebels: Transitions of Post-Yugoslav Slovenian Queerness on Film
Authors: Šepetavc Jasmina
Published: January 2025

The article looks at Slovenian queer images in the country’s post-independence feature cinema. While during Yugoslavian times Slovenian cinema contained complex, at times even radical queer imagery, the 1990s’ re-traditionalization of society was also reflected on film in the erasure of queerness. However, when queerness again became part of national cinematic images, it reflected the country’s complex transition and in-betweenness – between the legacy of Yugoslavia, the traditional values of the new state, and an ambition to quickly become part of the EU. This trajectory was neither linear nor one-directional (from Yugoslavia to the EU with its supposedly more liberal attitudes), but multilayered and messy. While queerness was at times portrayed in problematic ways or as something that cannot freely exist in the new national framework, it was nevertheless also a point of subversion, transgression, and recently alternative communal solidarity.