Gender Differences in Bleeding Problems and Implications for the Assessment of a Bleeding Disorder.
Authors: Pai Menaka , Liu Yang , Whittaker Susan , Arnold Emmy , Seecharan Jodi L. , Moffat Karen A. , Webert Kathryn E. , Cook Richard J. , Heddle Nancy , Hayward Catherine P.M. 
Published: April 2020

Introduction: The value of gender-specific questions in assessing patients referred for evaluation of bleeding problems is not well established. Moreover, the impact of having a bleeding problem on sexual health is unknown.

Methods: To learn more about gender differences in bleeding problems, questions about bleeding affecting sexuality and gender-specific issues were included in a detailed bleeding history questionnaire (CHAT: clinical history assessment tool). CHAT was administered to 256 female (F) and 66 male (M) patients referred for bleeding problems, and 67 F and 32 M healthy controls. A final diagnosis for each patient was established by independent reviews of medical records by two physicians, with discrepancies resolved by consensus. Data were expressed as prevalences among patients with bleeding disorders versus gender-matched healthy controls, with significantly increased bleeding risks expressed as odds ratios (OR).

Results: 62% of CHAT subjects had bleeding disorders (54 M, 205 F), most commonly affecting platelets or von Willebrand factor. Most subjects had experienced sexual intercourse. Men with bleeding disorders did not have significantly increased intercourse-related bleeding (5% vs. 13%, p=0.38) or bleeding affecting their sex life in other ways (8% vs. 4%, p=1.0) and they did not have increased gender-specific bleeding (p values&gt;0.38). However, women with bleeding disorders had significantly increased intercourse-related bleeding (38% vs. 3%, p&lt;0.0001; OR=20) and bleeding affecting their sex life in other ways (24% vs. 7%, p=0.006; OR=4.2). Affected women reported avoiding sexual activity (due to increased bleeding and bruising, pain and exhaustion), experiencing frustration and reduced self esteem. Women with bleeding disorders also had increased risks for: prolonged menses (50% vs. 12%, p&lt;0.0001; OR=7.8), menses interfering with lifestyle (56% vs. 22%, p&lt;0.0001; OR=5.2), menses requiring medical (43% vs 21%, p=0.0008; OR=3.0) or surgical therapy (26% vs 6%, p=0.0005; OR=5.5), uterine fibroids (18% vs.7%, p=0.008; OR=3.6), excessive bleeding during or after childbirth (50% vs. 13%, p&lt;0.0001; OR=12), excessive bleeding with miscarriages (55% vs. 17%, p=0.0002; OR=17), and feeling concerned about becoming pregnant or delivering a baby because of bleeding (23% vs. 2%, p=0.0001; OR=19). They did not have increased risks for pregnancy losses or bleeding during pregnancy (p values &gt;0.1). Although women with bleeding disorders had similar numbers of offspring as controls (means: 2.0 vs. 1.7), 38% had been told by a doctor not to become pregnant due to their bleeding problem.

Conclusions: Gender has an important impact on the manifestations of common bleeding disorders. Detailed questions about bleeding affecting sexual life, menses, and reproduction are useful in assessing women with bleeding disorders who are at greater risk for experiencing excessive bleeding with intercourse, menses and childbirth, that can negatively impact on lifestyle and sexual/reproductive health. Recognition of these issues has important implications for the diagnosis and management of individuals with bleeding disorders.