bluuebunny/crossref_metadata_2025 huggingface dataset:
Neoadjuvant Chemotherapy Followed by Radiofrequency Ablation Prolongs Survival for Ablatable Colorectal Liver Metastasis: A Propensity Score Matching Comparative Study
Authors: Chen Yizhen , Xu Youyao , Xu Linwei , Han Fang , Huang Yurun , Jiang Hang , Wu Jia , Zhang Yuhua
Published: October 2021

Background

Typically, colorectal liver metastasis (CRLM) is not a candidate for hepatectomy. Radiofrequency ablation (RFA) plays a critical role in unresectable CRLM patients. Nevertheless, high local tumor progression (LTP) and distant metastasis limit the development and further adoption and use of RFA. Neoadjuvant chemotherapy (NAC) has been widely used in resectable CRLM and is recommended by the guidelines. There are no studies on whether NAC can improve the prognosis in ablatable CRLM patients. The present study aimed to determine the feasibility and effectiveness of RFA plus NAC.

Methods

This retrospective cohort included CRLM patients from Zhejiang Cancer Hospital records, who received RFA from January 2009 to June 2020 and were divided into two groups according to the presence or absence of NAC. The Kaplan–Meier method was used to evaluate the 3-year local tumor progression-free survival (LTPFS), progression-free survival (PFS), and overall survival (OS) of the two groups. The propensity score matching was used to reduce bias when assessing survival. Multivariate Cox proportional hazards regression analysis was used to study the independent factors affecting LTPFS, PFS, and OS.

Results

A total of 149 CRLM patients (88 in the RFA alone group and 61 in the plus NAC group) fulfilled the inclusion criteria. Post-RFA complications were 3.4% in the RFA alone group and 16.4% in the plus NAC group. The 3-year LTPFS, PFS, and OS of the RFA only group were 60.9%, 17.7%, and 46.2%, respectively. The 3-year LTPF, PFS, and OS of the plus NAC group were 84.9%, 46.0%, and 73.6%, respectively. In the 29 pairs of propensity score matching cohorts, the 3-year LTPFS, PFS, and OS in the plus NAC group were longer than those in the RFA group (P < 0.05). NAC was an independent protective factor for LTPFS, PFS, and OS (P < 0.05).

Conclusions

For ablatable CRLM patients, RFA plus NAC obtained a better prognosis than RFA alone. Based on the current results, the application of NAC before RFA may become the standard treatment.
The Efficacy and Safety of Multiple Dose Regimens of Kudzu (Pueraria lobata) Root Extract on Bone and Cartilage Turnover and Menopausal Symptoms
Authors: Bihlet Asger Reinstrup , Byrjalsen Inger , Andersen Jeppe Ragnar , Simonsen Simone Faurholt , Mundbjerg Kamilla , Helmer Betina , Riis Bente Juel , Karsdal Morten Asser , Christiansen Claus
Published: October 2021

Background: Menopause is associated with detrimental changes in turnover of bone and cartilage and a variety of symptoms with negative impact on the quality of life. Naturally occurring isoflavones from Radix Pueraria lobata, Kudzu root, may possess chondroprotective and symptom-relieving properties, but efficacy and safety of dosing and dose frequencies required for pharmacological action is unclear.

Purpose: This clinical trial evaluates the efficacy on bone and cartilage turnover, menopausal symptoms, and safety of five dose regimens of Kudzu root extract administered either once, twice or three times daily in women with at least mild menopausal symptoms.

Materials and Methods: Fifty postmenopausal women were randomized equally into five different dose regimen groups of Kudzu root extract in a four-week, parallel group, open-label, single-center, exploratory study design. Biomarkers CTX-I and CTX-II reflecting bone and cartilage degradation, respectively, were assessed in blood samples and 24-h urine samples. Change from baseline in the Menopause Rating Scale (MRS) and subscales was evaluated. Safety endpoints were frequency of adverse events, changes in hematology and safety chemistry data, vital signs and electrocardiogram.

Results: Fifty women (Age 54.2 years, SD: 2.9) were randomized. After 4 weeks of treatment, biomarkers of bone resorption and cartilage degradation were statistically significantly reduced from baseline levels in the group receiving two capsules three times a day, serum/urine CTX-I (−18.4%, 95% CI: −8.1 to −27.5, p = 0.001/−34.2%, 95% CI: −21.6 to −44.7, p < 0.0001), urine CTX-II (−17.4% 95% CI: −2.5 to −30.0, p = 0.02). The observed effects were consistent across study groups but appeared to favour three times daily dosing. Four weeks of treatment led to statistically significant reductions in the MRS Total Score (p < 0.0001–0.03) in four out of five treatment groups. Kudzu root extract was well tolerated in all dose regimens, and no serious adverse events were reported.

Conclusion: The results indicate that Kudzu extract may possess beneficial effects on bone and cartilage health and may be a promising natural alternative to existing treatments for menopausal symptoms. Kudzu root extract was well tolerated for short-term treatment of mild to severe menopausal symptoms in women in all tested doses and dose frequencies.
Cardiovascular Responses to Simultaneous Diving and Muscle Metaboreflex Activation
Authors: Di Giacomo Annalisa , Ghiani Giovanna Maria , Todde Francesco , Tocco Filippo
Published: October 2021

Background: The aim of study was to assess hemodynamic changes during the simultaneous activation of muscle metaboreflex (MM) and diving reflex (DR) in a laboratory setting. We hypothesized that as long as the exercise intensity is mild DR can overwhelm the MM.

Methods: Ten trained divers underwent all four phases (randomly assigned) of the following protocol. (A) Postexercise muscle ischemia session (PEMI): 3 min of resting followed by 3 min of handgrip at 30% of maximum force, followed immediately by 3 min of PEMI on the same arm induced by inflating a sphygmomanometer. Three minutes of recovery was further allowed after the cuff was deflated for a total of 6 min of recovery. (B) Control exercise recovery session: the same rest-exercise protocol used for A followed by 6 min of recovery without inflation. (C) DR session: the same rest-exercise protocol used for A followed by 1 min of breath-hold (BH) with face immersion in cold water. (D) PEMI-DR session: the same protocol used for A with 60 s of BH with face immersion in cold water during the first minute of PEMI. Stroke volume (SV), heart rate (HR), and cardiac output (CO) were collected by means of an impedance method.

Results: At the end of apnea, HR was decreased in condition C and D with respect to A (−40.8 and −40.3%, respectively vs. −9.1%; p < 0.05). Since SV increase was less pronounced at the same time point (C = +32.4 and D = +21.7% vs. A = +6.0; p < 0.05), CO significantly decreased during C and D with respect to A (−23 and −29.0 vs. −1.4%, respectively; p < 0.05).

Conclusion: Results addressed the hypothesis that DR overcame the MM in our setting.
Language and Movement Synchronization in Dyadic Psychotherapeutic Interaction – A Qualitative Review and a Proposal for a Classification
Authors: Scheidt Carl Eduard , Pfänder Stefan , Ballati Arianna , Schmidt Stefan , Lahmann Claas
Published: October 2021

In individual psychotherapy verbal communication and movement synchronization are closely interrelated. The microanalysis of timing, rhythm and gestalt of movement has established dynamic movement coordination as a systemic property of the dyadic interaction. Movement synchronization supports and enhances the unfolding of linguistic meaning. In order to substantiate the importance of the concept of synchrony for adult psychotherapy we review evidence from developmental psychology and discuss approaches to measure synchrony with particular reference to the naturalistic setting of dyadic psychotherapy. As the concept of synchrony is still ambiguous, and the respective interactional phenomena are ephemeral and fluid, in the current paper we suggest a set of five criteria for the description of synchronization in general terms and eight additional criteria which specifically enable the description of phenomena of movement synchronization. The five general dimensions are: (1) context, (2) modality, (3) resources, (4) entrainment, and (5) time-lag. The eight categories for the description of movement synchrony are: (1) spatial direction, (2) amplitude, (3) sinuosity, (4) duration, (5) event structure, (6) phase, (7) frequency, and (8) content. To understand the process of participatory sense-making and the emergence of meaning in psychotherapy, synchrony research has to cope with the multimodality of the embodied interaction. This requires an integrated perspective of movement and language. A system for the classification of synchrony phenomena may contribute to the linking of variations and patterns of movement with language and linguistic utterances.
Case Report: “Niemann-Pick Disease Type C in a Catatonic Patient Treated With Electroconvulsive Therapy”
Authors: van Verseveld M. , Koens L. H. , de Koning Tom J. , Derikx R. L. E. , van Waarde J. A.
Published: October 2021

We describe a case of an adolescent male with Niemann-Pick Type C (NP-C), a neurodegenerative lysosomal lipid storage disorder, who presented with recurrent catatonia which required repeated treatment with electroconvulsive therapy (ECT). During the ECT-course, seizure threshold increased substantially, leading to questions about the influence of NP-C on neuronal excitability. In this exemplary ECT-patient, NP-C was diagnosed not until after the first ECT-course when initial psychopharmacology for catatonia had failed and antipsychotics and benzodiazepines showed significantside-effects. Clinicians should be aware of NP-C in patients referred for ECT, especially in the case of treatment resistance, neurological symptoms and intolerance of psychopharmacological drugs. As was shown in our NP-C patient, ECT can be repeatedly effective for catatonic features. In the literature, effectiveness of ECT in patients with NP-C has sparsely been reported. This case demonstrates that detection of NP-C is beneficial for patients because more optimal treatment with ECT can be provided earlier without further exposure to side-effects.
Having Babies in Soil: Is Sex Really Necessary?
Authors: Öztoprak Hüsna , Brandt Alexander , Solbach Marcel D. , Bast Jens , Schaefer Ina
Published: October 2021

Finding a partner and having sex to produce babies is a common way to reproduce. Yet, upon closer look, we see that nature provides many ways for reproduction. What about a world without males? What first sounds impossible is the reality for many organisms that reproduce asexually, meaning without having sex. Females produce daughters that are clones of themselves, so no partner is required and males are dispensable. An Example of such all-female societies are several species of oribatid mites, which live in soils. These mites were already on earth long before the dinosaurs. Have oribatid mites always been asexual? Why do they reproduce without males? Does asexual reproduction have any advantages? Keep reading to learn about asexual reproduction and why oribatid mites are a key organism to investigate the question, “Why sex?”.
Intraductal Papillary Mucinous Neoplasms of the Pancreas: A Review of Their Genetic Characteristics and Mouse Models
Authors: Li Jin , Wei Tao , Zhang Jian , Liang Tingbo
Published: October 2021

The intraductal papillary mucinous neoplasm (IPMN) is attracting research attention because of its increasing incidence and proven potential to progress into invasive pancreatic ductal adenocarcinoma (PDAC). In this review, we summarized the key signaling pathways or protein complexes (GPCR, TGF, SWI/SNF, WNT, and PI3K) that appear to be involved in IPMN pathogenesis. In addition, we collected information regarding all the genetic mouse models that mimic the human IPMN phenotype with specific immunohistochemistry techniques. The mouse models enable us to gain insight into the complex mechanism of the origin of IPMN, revealing that it can be developed from both acinar cells and duct cells according to different models. Furthermore, recent genomic studies describe the potential mechanism by which heterogeneous IPMN gives rise to malignant carcinoma through sequential, branch-off, or de novo approaches. The most intractable problem is that the risk of malignancy persists to some extent even if the primary IPMN is excised with a perfect margin, calling for the re-evaluation and improvement of diagnostic, pre-emptive, and therapeutic measures.
Cell Systems Bioelectricity: How Different Intercellular Gap Junctions Could Regionalize a Multicellular Aggregate
Authors: Riol Alejandro , Cervera Javier , Levin Michael , Mafe Salvador
Published: October 2021

Electric potential distributions can act as instructive pre-patterns for development, regeneration, and tumorigenesis in cell systems. The biophysical states influence transcription, proliferation, cell shape, migration, and differentiation through biochemical and biomechanical downstream transduction processes. A major knowledge gap is the origin of spatial patterns in vivo, and their relationship to the ion channels and the electrical synapses known as gap junctions. Understanding this is critical for basic evolutionary developmental biology as well as for regenerative medicine. We computationally show that cells may express connexin proteins with different voltage-gated gap junction conductances as a way to maintain multicellular regions at distinct membrane potentials. We show that increasing the multicellular connectivity via enhanced junction function does not always contribute to the bioelectrical normalization of abnormally depolarized multicellular patches. From a purely electrical junction view, this result suggests that the reduction rather than the increase of specific connexin levels can also be a suitable bioelectrical approach in some cases and time stages. We offer a minimum model that incorporates effective conductances ultimately related to specific ion channel and junction proteins that are amenable to external regulation. We suggest that the bioelectrical patterns and their encoded instructive information can be externally modulated by acting on the mean fields of cell systems, a complementary approach to that of acting on the molecular characteristics of individual cells. We believe that despite the limitations of a biophysically focused model, our approach can offer useful qualitative insights into the collective dynamics of cell system bioelectricity.
Acetyltransferase p300 Is a Putative Epidrug Target for Amelioration of Cellular Aging-Related Cardiovascular Disease
Authors: Ghosh Asish K.
Published: October 2021

Cardiovascular disease is the leading cause of accelerated as well as chronological aging-related human morbidity and mortality worldwide. Genetic, immunologic, unhealthy lifestyles including daily consumption of high-carb/high-fat fast food, lack of exercise, drug addiction, cigarette smoke, alcoholism, and exposure to environmental pollutants like particulate matter (PM)-induced stresses contribute profoundly to accelerated and chronological cardiovascular aging and associated life threatening diseases. All these stressors alter gene expression epigenetically either through activation or repression of gene transcription via alteration of chromatin remodeling enzymes and chromatin landscape by DNA methylation or histone methylation or histone acetylation. Acetyltransferase p300, a major epigenetic writer of acetylation on histones and transcription factors, contributes significantly to modifications of chromatin landscape of genes involved in cellular aging and cardiovascular diseases. In this review, the key findings those implicate acetyltransferase p300 as a major contributor to cellular senescence or aging related cardiovascular pathologies including vascular dysfunction, cardiac hypertrophy, myocardial infarction, cardiac fibrosis, systolic/diastolic dysfunction, and aortic valve calcification are discussed. The efficacy of natural or synthetic small molecule inhibitor targeting acetyltransferase p300 in amelioration of stress-induced dysregulated gene expression, cellular aging, and cardiovascular disease in preclinical study is also discussed.
Amino Ethers of Ortho-Phosphoric Acid as Extragents for Ethanol Dehydration
Authors: Klinov Alexander V. , Malygin Alexander V. , Khairullina Alina R. , Davletbaeva Alisa R. , Sazonov Oleg O. , Anashkin Ivan P. , Davletbaeva Ilsiya M.
Published: October 2021

Amino ethers of ortho-phosphoric acid prepared using triethanolamine; ortho-phosphoric acid; polyoxyethylene glycol, diethylene glycol, triethylene glycol and glycerol (AEPA-DEG/TEG/Gl) were investigated as extractants for the separation of aqueous ethanol solutions by extractive distillation. Using the method of open evaporation, the influence of the molecular structure of AEPA-DEG/TEG/Gl on the conditions of vapor–liquid equilibrium in ethanol–water solutions was studied. It has been shown that the addition of AEPA-DEG/TEG/Gl removes the azeotropic point. At the same time, the observed effect turned out to be significantly higher in comparison with the use of pure glycerol or glycols for these purposes. The UNIFAC model was used to calculate the activity coefficients in a three-component ethanol–water–AEPA-DEG/TEG/Gl mixture. Within the framework of this model, a division of AEPA-DEG/TEG/Gl molecules into group components is proposed. Previously unknown parameters of the groups PO–CH, PO–CH2, PO–OCH2, PO–NHCH2, PO–OH, and PO–H2O were determined from our own and published experimental data. The concentration dependences of the density and dynamic viscosity of AEPA-Gl aqueous solutions have been experimentally measured. Experimental studies of the extractive distillation of ethanol–water using AEPA-Gl as an extractant have been carried out in a column with bubble cap plates and a packing, and its high efficiency has been established.
A Comparison of Different Natural Groundwaters from Repository Sites—Corrosivity, Chemistry and Microbial Community
Authors: Somervuori Mervi , Isotahdon Elisa , Nuppunen-Puputti Maija , Bomberg Malin , Carpén Leena , Rajala Pauliina
Published: October 2021

In Finland, the repositories for low and intermediate-level radioactive waste (LLW and ILW) will be situated at three different geographical locations in about 60 to 100 m deep granite bedrock where the waste and waste containers can be subjected to anoxic groundwater containing microbes. The composition of groundwater varies in terms of chemistry and microbial activity in different locations. In this study, groundwater from the three repository areas was analyzed in respect to chemistry and microbial community. Corrosion tendency of three steel grades, carbon steel AISI/SAE 1005 and stainless steels AISI 304 and 316L, was studied in these groundwater environments using electrochemical methods. As a reference, measurements were also performed in simulated groundwater without microbes. The measurements show that corrosivity of the water and thus the steels’ performance differs depending on water origin. In addition, the groundwater differed remarkably in their chemical composition as well as abundance and diversity of microbial community between the sites. Consequently, the local environment has to be considered when evaluating the long-term evolution of disposal concepts.
Boosting COVID-19 Image Classification Using MobileNetV3 and Aquila Optimizer Algorithm
Authors: Abd Elaziz Mohamed , Dahou Abdelghani , Alsaleh Naser A. , Elsheikh Ammar H. , Saba Amal I. , Ahmadein Mahmoud
Published: October 2021

Currently, the world is still facing a COVID-19 (coronavirus disease 2019) classified as a highly infectious disease due to its rapid spreading. The shortage of X-ray machines may lead to critical situations and delay the diagnosis results, increasing the number of deaths. Therefore, the exploitation of deep learning (DL) and optimization algorithms can be advantageous in early diagnosis and COVID-19 detection. In this paper, we propose a framework for COVID-19 images classification using hybridization of DL and swarm-based algorithms. The MobileNetV3 is used as a backbone feature extraction to learn and extract relevant image representations as a DL model. As a swarm-based algorithm, the Aquila Optimizer (Aqu) is used as a feature selector to reduce the dimensionality of the image representations and improve the classification accuracy using only the most essential selected features. To validate the proposed framework, two datasets with X-ray and CT COVID-19 images are used. The obtained results from the experiments show a good performance of the proposed framework in terms of classification accuracy and dimensionality reduction during the feature extraction and selection phases. The Aqu feature selection algorithm achieves accuracy better than other methods in terms of performance metrics.
Beyond Dyadic Coupling: The Method of Multivariate Surrogate Synchrony (mv-SUSY)
Authors: Meier Deborah , Tschacher Wolfgang
Published: October 2021

Measuring interpersonal synchrony is a promising approach to assess the complexity of social interaction, which however has been mostly limited to dyads. In this study, we introduce multivariate Surrogate Synchrony (mv-SUSY) to extend the current set of computational methods. Methods: mv-SUSY was applied to eight datasets consisting of 10 time series each, all with n = 9600 observations. Datasets 1 to 5 consist of simulated time series with the following characteristics: white noise (dataset 1), non-stationarity with linear time trends (dataset 2), autocorrelation (dataset 3), oscillation (dataset 4), and multivariate correlation (dataset 5). Datasets 6 to 8 comprise empirical multivariate movement data of two individuals (datasets 6 and 7) and between members of a group discussion (dataset 8.) Results: As hypothesized, findings of mv-SUSY revealed absence of synchrony in datasets 1 to 4 and presence of synchrony in dataset 5. In the empirical datasets, mv-SUSY indicated significant movement synchrony. These results were predominantly replicated by two well-established dyadic synchrony approaches, Surrogate Synchrony (SUSY) and Surrogate Concordance (SUCO). Conclusions: The study applied and evaluated a novel synchrony approach, mv-SUSY. We demonstrated the feasibility and validity of estimating multivariate nonverbal synchrony within and between individuals by mv-SUSY.
Superconducting Surge Current Limiter
Authors: Kozak Sławomir
Published: October 2021

A superconducting fault current limiter (SFCL) for medium voltage networks cooled by a cryocooler was designed, built and tested by the current author. For the construction of this limiter, a high-temperature second generation superconducting tape (HTS 2G)—SF12100—was used. In this limiter, it is possible to change the working temperature. The possibility of changing the operating temperature allows for adjusting the parameters of the limiter to the electric power needs. Adjusting the parameters of the limiter to the power needs is a key problem to solve, resulting from the ambiguous characteristics of HTS tapes. Cooling with a cryocooler is the only solution in the case of a limiter for power industry applications. The electric power mechanism does not tolerate any liquids. After analyzing the experimental results and after analyzing the results from the numerical models of the limiter, the concepts of using superconductors to limit current in the power industry were changed: the transition from a superconducting fault current limiter (SFCL) to a superconducting surge current limiter (SSCL). Transition to the limiter operation system—surge current limitation—is associated with the reduction in the limiter operation time. The advantages of the transition from the SFCL to SSCL work system are presented.
Experimental Study on Co-Pyrolysis Characteristics of Household Refuse and Two Industrial Solid Wastes
Authors: Ma Hancheng , Bei Jianye , Zhan Mingxiu , Jiao Wentao , Xu Xu , Li Xiaodong
Published: October 2021

The calorific value of household refuse (HR) is greatly improved after classification, which includes the implementation of sufficient pyrolysis conditions. Therefore, a better pyrolysis effect can be achieved by co-pyrolysis with industrial solid waste (ISW) with high calorific value. In this work, HR and ISW were used as raw materials for co-pyrolysis experiments. The influence on the distribution of three-phase products after co-pyrolysis, the concentration of heavy metals and dioxins in the flue gas, and the distribution of PCDD/Fs isomers were studied. The results showed that, at a temperature of 600 °C and H/C = 1.3, of the formed material, the quantity of pyrolysis gas was approximately 27 wt.%, and the quantity of pyrolysis oil was approximately 40.75 wt.%, which mainly contained alkanes, olefins, and aromatic hydrocarbons. When S/C = 0.008, pyrolysis gas accounted for 25.95 wt.% of the formed material, and pyrolysis oil for 41.95 wt.% of the formed material. The ignition loss rate of pyrolysis coke was approximately 20%, and the maximal calorific value was 14,217 KJ/kg. According to the thermogravimetric experiment, the co-pyrolysis of HR and ISW can promote the positive reaction of pyrolysis, and the weight loss reached 62% at 550 °C. The emission of gaseous heavy metals was relatively stable, and the concentration of heavy metals slightly decreased. The main heavy metals in the ash were Cu, Fe, and Zn. The emission of dioxins could be effectively reduced by the pyrolysis of HR with ISW, and the produced dioxins were mainly synthesized from de novo synthesis. After pyrolysis, the toxic equivalent of dioxins in the flue gas was reduced from 0.69 to 0.29 ng I-TEQ/Nm3, and the distribution of dioxin isomers in the flue gas had little influence. The experimental results provide a theoretical basis for the application of co-pyrolysis technology with HR and ISW.
An All-Solid-State Lithium Metal Battery Based on Electrodes-Compatible Plastic Crystal Electrolyte
Authors: Zhao Bin , Wang Qi , Yuan Boheng , Lu Yafei , Han Xiaogang
Published: October 2021

Solid-state plastic crystal electrolytes (SPCEs) have attracted much attention due to their high ionic conductivity at room temperature and polymer-like plasticity. Herein, we made a LiFePO4||Li solid state battery based on SPCEs. A SPCE film is made up of glass fiber, succinonitrile (SN), lithium bis (triflu-romethanesulphonyl) imid (LiTFSI), and LiNO3. Glass fiber is introduced to improve the mechanical property, and LiNO3 served as an additive to stabilize electrolyte/Li interface. The SPCE film delivers a high ionic conductivity of 7.3 × 10−4 S cm−1 at room temperature and has excellent stability with Li-metal anode. SPCE is also infused into cathode electrode and used as the interface with cathode particles, which can access a large interface contact area and deform reversibly with volume change. The LiFePO4||Li solid state battery based on SPCE can work well at ambient temperature, which shows a high initial specific capacity of 121.4 mAh g−1 and has 86.9% retention after 90 cycles at 0.5 C.
Evaluating Insulation, Glazing and Airtightness Options for Passivhaus EnerPHit Retrofitting of a Dwelling in China’s Hot Summer–Cold Winter Climate Region
Authors: Liu Chenfei , Sharples Stephen , Mohammadpourkarbasi Haniyeh
Published: October 2021

Passivhaus EnerPHit is a rigorous retrofit energy standard for buildings, based on high thermal insulation and airtightness levels, which aims to significantly reduce building energy consumption during operation. However, extra retrofit materials are required to achieve this standard, which raises a contradiction between how to balance the environmental impacts of the retrofitting material inputs and extremely low energy consumption after retrofit. This motivated the analysis in this paper, which aimed to evaluate the possibilities of reducing the required retrofitting material inputs when trying to achieve the EnerPHit energy standard using a typical suburban dwelling in China’s hot summer–cold winter climate region as a case study. Firstly, how the insulation performance of each envelope component affected the building’s energy consumption was analysed. Based on this, sensitivity simulations of combinations of different insulation levels with different fabric components were investigated under four scenarios of insulation levels, airtightness and glazing choice. The final proposed retrofitting plans achieved the EnerPHit standard with insulation materials’ savings between 18% to 58% compared to a baseline retrofit plan, and this led, in turn, to 3.9 to 12.6 tonnes of carbon reductions. Moreover, an energy-saving of 87% in heating and 70% in cooling was achieved compared with the pre-retrofit dwelling.
Increasing Block Rate Electricity Pricing and Propensity to Purchase Electrical Appliances: Evidence from a Natural Experiment in Russia
Authors: Turdaliev Salim
Published: October 2021

This paper provides empirical evidence on the relationship between the increasing-block-rate (IBR) pricing of electricity and the propensity of households to buy major electrical appliances. I use a variation from a natural experiment in Russia that introduced IBR pricing for residential electricity in a number of experimental regions in 2013. The study employs household-level panel data, which records, among others, whether the household has purchased any major electrical appliances during the last three months. Using a difference-in-differences specification, I show that the purchase of major electrical appliances in the regions with IBR pricing has increased by more than 20% (or more than two percentage points). The findings suggest that price-based energy policies may be an effective tool in shaping the behaviour of households.
Reduced Scale Experimental Modelling of Distributed Thermal Response Tests for the Estimation of the Ground Thermal Conductivity
Authors: Morchio Stefano , Fossa Marco , Priarone Antonella , Boccalatte Alessia
Published: October 2021

The knowledge of the ground thermal properties, and in particular the ground thermal conductivity is fundamental for the correct sizing of the Ground Coupled Heat Pump (GCHP) plant. The Thermal Response Test (TRT) is the most used experimental technique for estimating the ground thermal conductivity. This paper presents an experimental setup aimed to realise a suitable scale prototype of the real borehole heat exchanger (BHE) and the surrounding ground for reduced scale TRT experiments. The scaled ground volume is realised with a slate block. Numerical analyses were carried out to correctly determine suitable geometric and operational parameters for the present setup. The scaled heat exchanger, inserted into the block, is created with additive technology (3D printer) and equipped with a central electrical heater along its entire depth and with temperature sensors at different radial distances and depths. Present measurements highlight the possibility to reliably perform a TRT experiment and to estimate the slate/ground thermal conductivity with an agreement of about +12% with respect to measurements provided by a standard commercial conductivity meter on proper cylindrical samples of the same material and onto 10 different portions of the slate block.
Valuation of Distributed Wind in an Isolated System
Authors: Barrows Sarah , Mongird Kendall , Naughton Brian , Darbali-Zamora Rachid
Published: October 2021

Remote communities are increasingly adopting renewable energy, such as wind, as they transition away from diesel energy generation. It is important to understand the benefits and costs of wind energy to isolated systems so that decision-makers can optimize their choices in these communities. There are few examples of valuation of wind energy as a distributed resource and numerous differences in valuation approaches, especially in the inclusion of environmental and economic impacts. We apply a distributed wind valuation framework to calculate the benefits and costs of wind in St. Mary’s, Alaska, to the local electric cooperative and to society, finding that the project does not have a favorable benefit-to-cost ratio unless societal benefits are included, in which case the benefit-to-cost ratio is nearly double. Government funding is important to reducing the initial capital expenditures of this wind project and will likely be the case for projects with similar characteristics. Additional fuel savings benefits are potentially possible for this project through technological additions such as energy storage and advanced controls.
Tree-Ring Based Reconstruction of Historical Fire in an Endangered Ecosystem in the Florida Keys
Authors: Stachowiak Lauren A. , Rochner Maegen L. , Schneider Elizabeth A. , Harley Grant L. , Collins-Key Savannah A. , Bonawitz Hunter A.
Published: October 2021

Big Pine Key, Florida, is home to one of Earth’s largest swaths of the critically-endangered dry forests. Known as pine rocklands, this fire-adapted ecosystem must experience regular fire to persist and remain healthy. Pine rocklands are composed of a sole canopy species: the South Florida slash pine (Pinus elliottii var. densa), along with a dense understory of various woody and herbaceous species, and minimal surface moisture and soil development. Slash pine record wildfire activity of the surrounding area via fire scars preserved within the annual tree rings formed by the species. Our study used dendrochronology to investigate the fire history of the pine rocklands on Big Pine Key, specifically within and around the National Key Deer Refuge (NKDR) because it is the largest segment of unfragmented pine rockland on the island. We combined the results found within the NKDR with those of a previous study completed in 2011, and incorporated historical documents and reports of prescribed and natural fires through November 2019 into our evaluation of fire history on Big Pine Key. We conclude that prescribed burning practices are vital to truly restore natural fire behavior, and repeated burning on these islands in the future must be prioritized.
Computational Fluid Dynamics Using the Adaptive Wavelet-Collocation Method
Authors: Mehta Yash , Nejadmalayeri Ari , Regele Jonathan David
Published: October 2021

Advancements to the adaptive wavelet-collocation method over the last decade have opened up a number of new possible areas for active research. Volume penalization techniques allow complex immersed boundary conditions to be used with high efficiency for both internal and external flows. Anisotropic methods make it possible to use body-fitted meshes while still taking advantage of the dynamic adaptability properties wavelet-based methods provide. The parallelization of the approach has made it possible to perform large high-resolution simulations of detonation initiation and fluid instabilities to uncover new physical insights that would otherwise be difficult to discover. Other developments include space-time adaptive methods and nonreflecting boundary conditions. This article summarizes the work performed using the adaptive wavelet-collocation method developed by Vasilyev and coworkers over the past decade.
Analysis of a Nonlinear ψ-Hilfer Fractional Integro-Differential Equation Describing Cantilever Beam Model with Nonlinear Boundary Conditions
Authors: Kotsamran Kanoktip , Sudsutad Weerawat , Thaiprayoon Chatthai , Kongson Jutarat , Alzabut Jehad
Published: October 2021

In this paper, we establish sufficient conditions to approve the existence and uniqueness of solutions of a nonlinear implicit ψ-Hilfer fractional boundary value problem of the cantilever beam model with nonlinear boundary conditions. By using Banach’s fixed point theorem, the uniqueness result is proved. Meanwhile, the existence result is obtained by applying the fixed point theorem of Schaefer. Apart from this, we utilize the arguments related to the nonlinear functional analysis technique to analyze a variety of Ulam’s stability of the proposed problem. Finally, three numerical examples are presented to indicate the effectiveness of our results.
Yagan Heritage in Tierra del Fuego (Argentina): The Politics of Balance
Authors: Fiore Danae , Butto Ana , Vargas Filgueira Victor
Published: October 2021

This paper analyses the tangible and intangible Yagan heritage contents exhibited by the Museo del Fin del Mundo (MFM, Ushuaia, Tierra del Fuego, Argentina) and presented during its guided tour led by Yagan Community Counsellor Victor Vargas Filgueira. We show how the critical outlook of Fuegian history offered in the latter challenges the traditional past-only fossilized view of the Yagan, building past–present links and helping to overcome biased hegemonic discourses. We also discuss how employing a member of the Yagan Community at the MFM has been an efficient and low-budget strategy that helps to comply with some Goals of the UN 2030 Agenda for Sustainable Development, which are difficult to attain in developing countries. Significant outcomes of this process include: (a) providing a full-time formal job to a member of an Indigenous Community who has been traditionally dispossessed of/in their own territory; (b) acknowledging him as a knowledge holder and valuable member of society; (c) moving the role of Yagan People from subject to agent of the MFM. This process has fostered the dialogue between Yagan voices and academic discourses, challenging traditional Western dichotomies-ecology/economy, natural/cultural heritage, and so forth, and contributing to the discussion of key concepts on sustainability and engagement.
The Riverside Roads of Culture as a Tool for the Development of Aitoloakarnania
Authors: Moropoulou Antonia , Lampropoulos Kyriakos , Vythoulka Anastasia
Published: October 2021

Cultural routes are a well-established development tool to highlight and promote a region’s cultural and environmental reserve, as well as having a positive impact on a region’s socio-economic development. Underdeveloped or rural areas, which have limited financial and technological resources available, often envision cultural routes as a useful development tool to cater to their needs. However, unless these cultural routes are designed and implemented based on the principles of a circular economy or while respecting the region’s cultural identity and heritage, their impact will not be significant. The region of Aitoloakarnania is the poorest prefecture of Greece. The prefecture served as a case study to demonstrate that the utilization of its cultural and architectural heritage can be based on the identification, documentation, and the reveal of paths of cultural tourism along the region’s main natural features, namely its rivers, lakes, lagoons, and coastline. Τhe density and the representative distribution of the monuments in the area, in combination with the unique natural environment of the prefecture, led to the configuration of a mild design of cultural routes, promoting the revealing of both the cultural and the natural landmarks of Aitoloakarnania. In this framework, certain cultural paths were defined. The first one, along the Acheloos River, includes sites of natural heritage, ancient and medieval monuments (castles, fortifications, monasteries, churches, burial sites, archaeological sites, etc.). The other cultural path regards sites along the Evinos River and Trichonida Lake, which includes similar monuments and traditional settlements. A similar cultural path regards cultural sites and points of interest along the coastal parts of the prefecture, and in particular, a path initiating from the historic city of Nafpaktos and following the route to the west, it reaches the Venetian castle of Plagia, opposite of Lefkada. These cultural paths fuse along their routes sites of natural heritage, sites of archaeological and cultural interest, and sites of historic importance to the region. This amalgamation of different types of cultural sites, integrated into a single cultural entity, provide the means for the local and regional development in a sustainable approach while ensuring and disseminating the region’s brand and history.
The Antikythera Mechanism: The Prove of the Accuracy of the Astronomical Calculations Based on It
Authors: Efstathiou Kyriakos , Efstathiou Marianna , Basiakoulis Alexandros , Kokkinos Neofytos
Published: October 2021

The Antikythera Mechanism is the oldest extant complex geared device, an amazing analogue computer. It was built approximately 2150 years ago. The device was operated manually by a user, setting a date in a dial. All necessary calculations were made using a set of gears (at least 39), while the results were displayed on several scientific scales. The Mechanism was used to calculate astronomical phenomena, such as solar and lunar eclipses. After an extensive description of the Mechanism, the main objective of the following paragraphs is to demonstrate the accuracy of its predictions.
Citizen Science in Vegetable Garden Cultivar Evaluation in Tennessee
Authors: Sykes Virginia R. , Bumgarner Natalie R. , Keadle Stefanie Brooke , Wilson Aleksandra , Palacios Francisco
Published: October 2021

Edible food production is a growing area of horticultural interest that can engage multiple generations of rural to urban residents with varying levels of experience. Residential or community garden food production can provide many benefits, including the production of healthy produce, establishment of community or social connections, and increased physical activity. Regardless of experience, food gardeners are interested in growing crops and cultivars well-suited to their region and which provide both productivity and crop quality. This means that cultivar selection is a common question for gardeners. However, formal cultivar evaluation is relatively rare in the non-commercial food production sector due to the number of cultivars, the challenges of replicated trial management, and the scarcity of public researchers focused on consumer horticulture. This limits the information available to support new gardeners, which lowers the chances of overall success including high-quality harvests. Such crop and variety selection questions are common for Extension personnel in the United States as well as many others who work with gardeners. Even with this high level of interest, funding for consumer garden trials is limited and the cost of replicated trials across various geographical sites is high. To fill this gap in research and address the need for high-quality data to support education, University of Tennessee Extension and research faculty have developed a citizen science approach called the Home Garden Variety Trial (HGVT) program. The HGVT is a collaborative effort between Extension and research faculty and educators, who select trials, provide seeds, and compile data, and citizen scientists around the state, who conduct the trials using their usual gardening practices in their own home or community gardens. Beginning in 2017, the collaborators have conducted five years of research involving over 450 individual gardeners in more than half of the counties in Tennessee. The HGVT is a novel and effective tool to introduce gardeners to new crops and cultivars while providing previously unavailable data to researchers. Together, researchers and home gardeners collect and compile data that supports residential and community food production success while engaging new and experienced gardeners in participatory science research.
Dissemination and Implementation Science Approaches for Occupational Safety and Health Research: Implications for Advancing Total Worker Health
Authors: Guerin Rebecca J. , Harden Samantha M. , Rabin Borsika A. , Rohlman Diane S. , Cunningham Thomas R. , TePoel Megan R. , Parish Megan , Glasgow Russell E.
Published: October 2021

Total Worker Health® (TWH), an initiative of the U.S. National Institute for Occupational Safety and Health, is defined as policies, programs, and practices that integrate protection from work-related health and safety hazards by promoting efforts that advance worker well-being. Interventions that apply the TWH paradigm improve workplace health more rapidly than wellness programs alone. Evidence of the barriers and facilitators to the adoption, implementation, and long-term maintenance of TWH programs is limited. Dissemination and implementation (D&I) science, the study of methods and strategies for bridging the gap between public health research and practice, can help address these system-, setting-, and worker-level factors to increase the uptake, impact, and sustainment of TWH activities. The purpose of this paper is to draw upon a synthesis of existing D&I science literature to provide TWH researchers and practitioners with: (1) an overview of D&I science; (2) a plain language explanation of key concepts in D&I science; (3) a case study example of moving a TWH intervention down the research-to-practice pipeline; and (4) a discussion of future opportunities for conducting D&I science in complex and dynamic workplace settings to increase worker safety, health, and well-being.
“Making Peace” with Bodies and Sexual Selves: Changes during COVID-19 among Adults in the United States
Authors: Bowling Jessamyn , Basinger Erin , Montanaro Erika A.
Published: October 2021

The COVID-19 pandemic has negatively impacted the physical and mental health of many and has necessitated widespread societal shifts, including changes to work and family activities. These changes have impacted individuals’ identity, including their sexual self-image and body image, yet research on perceptions of these changes is missing. This study reports on quantitative and qualitative data from an electronic survey with adults in the United States (N = 326) to examine these perceptions. Body appreciation did not significantly differ between demographic groups. Themes emerging from the qualitative results included changes in general self-image (becoming more restricted or disempowered), changes in sexual self-image (deepening, becoming more sexy/sexual, or less sexy/sexual), and changes in body image (positive, negative, and neutral). Our findings point to positive, negative, and neutral effects on sexual self-image and body image, implying that nuanced approaches are needed to understand how identity has transformed as a result of the COVID-19 pandemic.
Influence of Chronic Exposure to Exercise on Heart Rate Variability in Children and Adolescents Affected by Obesity: A Systematic Review and Meta-Analysis
Authors: Dias Rodrigo M. , Moraes Íbis A. P. , Dantas Maria T. A. P. , Fernani Deborah C. G. L. , Fontes Anne M. G. G. , Silveira Ana C. , Barnabé Viviani , Fernandes Marcelo , Martinelli Patrícia M. , Monteiro Carlos B. M. , Garner David M. , Abreu Luiz C. , Silva Talita D.
Published: October 2021

Background: Sedentary lifestyles are increasingly common amongst children, and insufficient physical activity is a global epidemic estimated to contribute to future incapacities and potential deaths. Objective: We aimed to increase the amount of evidence concerning the effect of chronic exposure to exercise on heart rate variability in children and adolescents affected by obesity. Methods: A systematic review commenced following the PRISMA guidelines developed by Web of Science, Virtual Health Library, PubMed, Cochrane Library, Embase, Ovid, Medline Complete, and Scopus using keywords obtained from the Descriptors in Health Sciences and Medical Subject Headlines (MeSH) terms. We considered (1) Population: Pediatric individuals affected by obesity; (2) Intervention: Exercise; (3) Control: Pre-intervention and sedentary; (4) Outcomes: Clearly presented primary parameters; and (5) Studies: Clinical trials, case controls, case reports, and case series. Results: 11 articles were involved and predominantly included procedures observed during approximately 12 weeks with a distribution of three sessions per week, each session being 30–60 min of aerobic exercise; additionally, the exercise grades were typically completed at a percentage of subjects’ maximum heart rates. The meta-analyses displayed a significant effect on the domains of time (R-R interval, SDNN, rMSSD), frequency (HF ms2, HF (n.u.), LF/HF), and the non-linear index (SD1). Conclusions: Chronic exposure to exercise influences heart rate variability in children and adolescents affected by obesity by elevating the variability and parasympathetic activity and improving the sympathetic-vagal balance. Exercises should be recommended for the improvement of cardiac autonomic modulation to prevent the likelihood of further chronic diseases.