bluuebunny/crossref_metadata_2025 huggingface dataset:
Tempos sombrios de pandemia e fome
Authors: Maluf Renato S.
Published: June 2020

Jogar luz sobre as inumanidades é um modo de inserir um pouco de humanidade no âmbito público do Brasil de hoje. Cabe iniciar pela desumanidade mais gritante que é o desprezo pela vida e sofrimento alheios emanado da Presidência da República, ministros e assessores próximos, felizmente, incapazes até o momento de paralisar completamente o serviço público federal. Chamo a atenção também para a insistência, mesmo frente a tragédia, numa agenda econômica perversa mais do que apenas injusta, como se nota na gestão do auxílio emergencial aceito a contragosto e, por isso, fixado em valor modesto.
Effect of Aloe vera extract for reducing formaldehyde level in tuna fish for halal and thoyyib food
Authors: Rullyansyah Subhan , Azizah Fitrotin , Kunsah Baterun
Published: June 2020

This study aims to determine the effect of Aloe vera extract in reducing formaldehyde levels in tuna processed into "pindang" after being given Aloe vera extract. This type of research is experimental. The population in this study was boiled fish sold in the Sawotratap Market. This research was conducted at the Laboratory of Chemistry at the University of Muhammadiyah. Data were analyzed using analysis of variance at a significant level α = 0.05 followed by the Duncan test. The average formaldehyde concentration before being given Aloe vera extract at a concentration of 0% is equal to 23.7 mg / L, and the lowest formalin content in boiled fish with 100% treatment is equal to 5.6 mg / L. Aloe vera extract showed a significant decrease in formaldehyde levels in boiled fish (p <0.05). It can be concluded that the administration of Aloe vera extract is effective in reducing formaldehyde levels.
Toxemic and complex immune syndromes in patients with malignant cerebral neoplasms
Authors: Seliverstov R. Yu. , Olyushin V. Ye. , Shatrov V. A. , Gurchin A. F.
Published: June 2020

The goal of the research was studying the key mechanisms of pathogenesis of toxemic and complex immune syndromes in patients with malignant cerebral neoplasms, and also studying the possible ways of correction of such syndromes.
Comparative characteristics of cognitive disorders in patients with toxix (mercury) and vascular (atherosclerosclerotic) encepalopathy
Authors: Katamanova Ye. V. , Lakhman O. L. , Andreyeva O. K. , Shevchenko O. I. , Konstantinova T. N.
Published: June 2020

The neurophysiological (the registration of induced potentials P300) and the psychological examinations of 70 patients, males, with chronic mercury intoxications (ChMI) and discirculatory encephalopathy (DE) have been performed with aim to reveal the features of cognitive disorders (CD). The study results have shown the presence of light CD and small demention in the patients of both groups, preferably, of subcork type for the patients with ChMI and preferably of cork type – for the patients with DE.
The basis of membrane stabilized effect of kopaxon in multiple sclerosis
Authors: Reikhert L. I. , Kicherova O. A. , Sokolova A. A. , Molchanova Zsh. I.
Published: June 2020

We have studied the influence of kopaxon on the structure of lipid phase of cellular membranes of red corpuscles, the condition of process of peroxide lipids oxidation and the system of antioxidative defence of 58 people with remittent form of multiple sclerosis. On the grounds of analysis of dynamics of laboratory index, membrane stabilized effect of this preparation was proved.
The gait disorders diagnostic method with using the laser range finder in patients with cerebellar ataxia syndrome
Authors: Prokopenko S. V. , Lyapin A. V. , Ondar V. S. , Zhivayev V. P. , Prokopenko V. S.
Published: June 2020

The aim of the study was assessment of gait parameters with a laser range finder use in patients with cerebellar ataxia syndrome. There are reliable differences in the relative stride length and stride variability coefficient for the patients with ataxia in comparison with the healthy middle aged people was found.
Gender aspects of mild cognitive impairment
Authors: Skulskaya N. I. , Nadezhdina M. V. , Osinceva Ye. V. , Zhezher M. N.
Published: June 2020

Neuropsychological research and analysis of level testosterone and estradiol among men and women at age from 50 to 60 were carried out. Two groups were formed. The first group was of patients with complaints bad memory and concentration, and the second group was of patients with out any complaints. The change for certain of results the neuropsychological tests between two groups of patients were fixed. The results of long-term memory were more sensible. The correlation between different level of testosterone and results of neuropsychological tests among men and women was fixed. The correlation between level of estradiol and results of neuropsychological tests was not fixed.
Chronic inflammation and microflora in ENT organs in patients with multiple sclerosis
Authors: Teplov A. V. , Klimova I. I. , Subbotin A. V. , Arefiyeva Ye. G.
Published: June 2020

The paper presents the results of the analysis of nasal cavity and stomatopharynx condition in the group of patients with multiple sclerosis. Microflora, immunological status and inflammatory changes of mucous membranes are studied. In the group of patients with multiple sclerosis the frequency of dysbiotical changes and chronic ENT diseases is higher than in the group of comparison. The correlation between frequency of dysbiosis and immunological status disturbances is shown.
Pathophysiological and clinical problems of cellular immunotherapy of digestive system cancer. Critical review
Authors: Khlusova M. Yu. , Khlusov I. A. , Antipov S. A. , Dambayev G. Ts.
Published: June 2020

The review is devoted to the methods of bioimmunotherapy of oncological pathology used in the clinic for the recent 20—25 years and, to the higher extent, the principles of cellular immunotherapy of cancerous epithelial tumors of the digestive system. The surgical method is recognized as a «gold standard» in the therapy of the digestive system cancer. Bioimmunotherapy of the digestive system cancer has not achieved the sufficient clinical efficiency. In this connection, new pathophysiological approaches to biotherapy of the digestive system cancer based, in particular, on original results of Russian scientists are analyzed.
Clinical-functional justification of combined pelotherapy in medical rehabilitation of elderly hypertension patients
Authors: Smirnova I. N. , Sher I. I. , Alaitseva S. V.
Published: June 2020

A method is developed for the treatment of elderly hypertension patients. The method consists in the combined use of peaty mud applications on lower limb regions, magnetolaser therapy, and electrosleep. The investigation involved 88 patients with the verified hypertension diagnosis. It has been found that the combined medical rehabilitation exerts the positive effect of the main links of pathogenesis, improves the adaptation abilities of an organism, and thus increase the efficiency of treatment and the patients’ life quality.
The state of renal functions and urokinase activity of urine in newborns and the first month infants with congenital anomalies of the kidney and urinary tract
Authors: Zenchenko O. A. , Suvorova A. V.
Published: June 2020

In our own experience we examined a functional condition of kidneys and urokinase activity of urine at 105 newborns and children of early age with congenital anomalies of the kidney and urinary tract. Inspection was spent at all newborn children after revealing of anomalies of uric system by means of ultrasonic diagnostics. It is established that functional infringements of kidneys at children with congenital anomalies of the kidney and urinary tract have certain sequence: decrease urokinase activity of urine, formation tubular dysfunctions, infringement glomerular functions of kidneys.
Rehabilitation of patients with benign vocal fold lesions
Authors: Kotyanina O. V.
Published: June 2020

Benign vocal fold lesions is the largest group of larynx diseases. At the present time the fundamental principle in treatment of benign laryngeal lesions is the combined therapy including surgical, medical and phonopedic methods of voice rehabilitation by indications.
Russian-German Competence Center on the Problem of Infectious Diseases as a new structural division of the Siberian State Medical University
Authors: Urazova O. I.
Published: June 2020

The article contains information about Koch-Metchnikov Siberian Competence Centre which deals with the problem of infectious diseases. It is a new structural division of Siberian State Medical University which was founded in 2008 on the initiative of the university administration together with a German social institution — Koch—Metchnikov Forum. The article describes backgrounds of the foundation of Siberian Competence Centre, its main aims, tasks, the most perspective areas of Russian-German cooperation in the sphere of fundamental and practical medicine, results of the joint scientific-educational activity as well as outcomes of implementation of the program of experience and knowledge exchange in the network of professional trainings, international conferences and seminars.
The significance of connective tissue dysplasia in the development of cervical incompetence
Authors: Kokh L. I. , Nazarenko L. P. , Tsukanova J. V. , Satysheva I. V.
Published: June 2020

100 pregnancy women at 13—30 weeks gestations were examined to study significance of connective tissue dysplasia in the development of cervical incompetence. Data of objective examination, anamnesis, physical examination. The role of connective tissue dysplasia was firmed by presence its markers, loss of weight, diseases with connective tissue dysplasia.
Use of cellular therapy as a way to improve efficiency of thyroid gland autotransplantation
Authors: Galyan A. N.
Published: June 2020

In the experiment carried out on 150 Vistar line male rats after a thyreodectomy a thyroid gland tissue was autotranspalted into big omentum to prevent postoperative hypothyroidism. Three-month study and comparative analysis of morphology and functional state of the transplanted tissue showed high levels of thyroid hormone reactivation and transplant viability owing to the use of the cellular suspension of autologous pluripotent mesenchymal stromal cells.
Morphofunctional properties of stromal stem cells incubating in vitro under dynamic conditions
Authors: Zapuskalov I. V. , Krivosheina O. I. , Khlusov I. A. , Martusevich Ya. A. , Shevtsova N. M. , Zaytsev K. V. , Kochmala O. B.
Published: June 2020

The culture of stromal stem cells was incubated under constant and dynamic conditions. The incubation period was lasting 48 h. Intracellular enzyme activity of stromal stem cells were carried out with cytochemical methods. Alkaline phosphatase activity was increased under dynamic conditions, differentiation of stromal stem cells being accelerated comparatively steady-state conditions.
Formation of mental disorders in dysmenorrea at early reproductive age
Authors: Nasyrova R. F. , Sotnikova L. S.
Published: June 2020

Clinical-psychopathological examination has been carried out as well as quality of life has been studied in female patients with dysmenorrea in period of puberty and at early reproductive age. It has been revealed that mental disturbances in studied nosology were represented by their high prevalence. In girls-adolescents with this pathology neurotic reactions were found more frequently, in women with dysmenorrea at early reproductive age persistent neurotic states predominated. It has been shown that formation and dynamic of mental disorders were determined by somatogenic, psychogenic and social factors.
Influence of polymorphism of the gene of inducible NO-synthase on the achievement of control of bronchial asthma in children against the background of inhalation corticosteroid therapy
Authors: Smirnova I. Yu. , Petrova I. V. , Deyev I. A.
Published: June 2020

The polymorphism of the gene of inducible NO-synthase (iNOS) was studied in 65 children with bronchial asthma (BA). The goal was to determine the probability to achieve the BA control in children against the background of inhalation glucocorticosteroid (IGCS) therapy depending on the polymorphism of the iNOS gene. The genotype of polymorphism of the iNOS gene was studied by the method of polymerase chain reaction. It has been found that the achievement of BA control in children against the background of the IGCS treatment is associated with the carriage of homozygote of «wild» allele G of polymorphism G954C of the iNOS gene. The absence of BA control is related to the presence of pathological allele . The result obtained can favor the pre С - diction of the uncontrollable BA course in children.
Comparative assessment of antioxidant properties of polyphenols from heartwood and Maackia amurensis callus culture
Authors: Azarova O. V. , Bryukhanov V. M. , Bulgakov V. P. , Zverev Ya. F. , Lampatov V. V. , Fedoreyev S. A.
Published: June 2020

On long-term introduction to rats in dosage 100 mg/kg polyphenol complexes from heartwood and callus culture of Maackia amurensis Rupr. et Maxim. had a marked influence on the activity of free radical oxidation. Under conditions of induced oxidant stress both polyphenol complexes inhibited prooxidant activity directly affecting the products of free radical oxidation. Inhibiting influence on the production of oxygen active forms that is characteristic for both phytocomplexes is determined by inhibition of mechanisms both enzymatic and non-enzymatic defense.
The investigation of acute toxicity of water-soluble polysaccharides extracted from calamus root (Acorus calamus L.)
Authors: Guriyev A. M. , Belousov M. V. , Yusubov M. S. , Akhmedzhanov R. R. , Zuyeva Ye. P. , Lopatina K. A.
Published: June 2020

An investigation for a possible acute toxicity of the complex of water-soluble polysaccharides (WSPS) extracted from calamus root (Acorus calamus L.) has been performed. No toxic effect has been observed on the organisms of experimental animals after a twofold intragastric, subcutaneous, and intravenous introduction of the highest maximum dose of the WSPS being investigated. The results of the experiments did not allow detecting the average fatal dose (LD50) of the WSPS being investigated as no deaths among the experimental animals had been observed. The obtained data lead to the conclusion that the WSPS of calamus root are to be added to Substance Hazard Class IV (low hazard substances) in compliance with State Standard GOST 12.1.007-76.
Characterization of cellular immune response associated with infection intensity in chronic opisthorchiasis patients
Authors: Ilyinskikh Ye. N. , Ilyinskikh N. N. , Ilyinskikh I. N. , Lepyokhin A. V. , Yurkin A. Yu. , Buzhak N. S.
Published: June 2020

The aim of this work was to assess the lymphocyte transformating responses to stimulation with antigens or mitogens in chronic opisthorchiasis patients with low and high degrees of infection intensity. The heavily infected patients demonstrated the lowest levels of stimulated lymphocyte transformating response in vitro, and CD8+ or CD16+ counts in peripheral blood.
Surgical treatment of pelvic inflammatory disease
Authors: Balakshina N. G. , Kokh L. I.
Published: June 2020

Delayed care of pelvic inflammatory disease as a risk factor for impaired fertility.
Role of psychological factors in achievement adequate glicemic the control in children and teenagers wiht the diabetes of 1 type
Authors: Samoilova Y. G. , Kravets Ye. B. , Oleinik O. A.
Published: June 2020

Children and the teenagers suffering СD of 1 type, despite of spent therapeutic actions, training in «School of a diabetes», not always reach full indemnification СD. The lead complex of psychological inspection of 200 children and teenagers with a diabetes of 1 type in the age of from 5 till 17 years with duration of disease from 1 year till 13 years. The control group has been presented by 150 healthy contempoparies comparable on a floor, to age, a place of residing and not having chronic diseases. As a result of carried out research psychological features of the person which influence adaptation to disease, efficiency of achievement of the harmonious attitude to illness and definitions of therapeutic strategy of treatment at various stages of evolution of disease. In process of progressing a diabetes personal specificity decreases, symptoms ригидности, emotional flatness, apathy accrue.
Correction of psycho-emotional stress among primary schoolchildren with special educational needs with the use of biofeedback
Authors: Kistenyova R. A. , Kistenyov Yu. V. , Pekker Ya. S. , Brazovskiy K. S. , Brazovskaya N. G. , Fokin V. A.
Published: June 2020

The peculiarities of correction of psycho-emotional stress among primary schoolchildren with special educational needs with the use of biofeedback on the basis of statistic analysis of the heart rate are presented. The methodology developed by the authors is realized in the hardware-software complex «Boston». Results of the conducted research have shown that the use of BOS-training leads to definite reduction of psycho-emotional stress as well as to improvement of activity indicators among children with special educational needs.
Neurorehabilitation (neurobiofeedback) in virtual network
Authors: Guk R. Yu. , Tarasov Ye. A. , Sklyar M. M.
Published: June 2020

In this paper we discuss the results of the second stage of the network rehabilitation based on the mechanisms of selfregulation which are activated by using of electromyography biofeedback. The data on the efficiency of the use of biofeedback technology in treatment of periphery paresis and spinal injuries at home are given.
Quality of life in primary headaches and biofeedback effects
Authors: Starikova N. L.
Published: June 2020

Determinants of quality of life (QoL) in primary headaches remain unclear. We studied QoL in 107 patients (50 migraine patients, 57 tension-type headache — TTH-patients) and 10 healthy subjects. QoL in headache patients was reduced and strongly correlated with passive coping strategies preference, levels of anxiety and depression. In migraine QoL depended on duration of the disease, intensity of pain and MIDAS score. In TTH no clinical features of the disease influenced QoL. Biofeedback showed high effectiveness in primary headaches which depended on coping strategies of patients.
Biofeedback: running on the spot or stepping forward? (instead of a preface)
Authors: Shtark M. B.
Published: June 2020

Biofeedback: running on the spot or stepping forward? (instead of a preface).
Morphofunctional characteristic of fetoplacentar barrier at the pregnancy complicated herpes-virus infection
Authors: Lutsenko M. T. , Andriyevskaya I. A.
Published: June 2020

Herpes-virus infection decrease of activity of villus Bcl-2 was increased in process of increase of a credit of antibodies to virus herpes. The increase of activity kaspasa-3 created action on DNK nucleus sincythiotrophoblast.
Association of cytokines gene polymorphisms (TNF and IL8) with chronic obstructive pulmonary disease development
Authors: Seitova G. N. , Bukreyeva Ye. B. , Kremis I. S. , Puzyryov V. P.
Published: June 2020

The association of the tumor necrosis TNF-α –308G/A polymorphism and interleukin-8 genetic IL8 –251А/Т polymorphism with the development of the chronic obstructive lung disease (COLD) in two Tomsk populations (Siberian Tatars and Russians) has been studied. The data on interethnic differences in the structure of COLD susceptibility have been obtained. In Siberian Tatars, the TNF –308G allelic variant plays a role in the COLD development. In Russians, no association of the studied genetic markers with COLD was reveled.
Neurological manifestations of ixodic tick-borne borreliosis associated with chronic opisthorchiasis in the Tomsk Region
Authors: Pershina S. A. , Zhukova N. G. , Lukashova L. V. , Udintseva I. N.
Published: June 2020

A comparative analysis of neurological manifestations in patients with acute ixodic tick-borne borreliosis (ITB) and patients with ITB associated with chronic opisthorchiasis has been carried out. It has been found that at ITB in the acute phase, nearly all parts of the nervous system are involved in the pathological process. Diseases of central parts of the nervous system were found in 86.7% patients with the monoinfection and in 96.7% patients with ITB associated with chronic opisthorchiasis, diseases of the vegetative part were found in 75.0 and 83.3% patients, and peripheral failures were found in 18.3 and 48.3% patients, respectively. In the structure of neurological pathology of the acute stage of ITB with chronic opisthorchiasis, the prevalence of the combined disease of different parts of the nervous system (93.3%), the more frequent occurrence (96.7%) and higher intensity of headaches (more than 4 points by the visual analog scale), vertigo (76.7%), cognitive failures (35.0%), signs of the vegetative disfunction syndrome (95.0%), and peripheral neuropathy (48.3%) were diagnosed.
Treatment of herpetic stomatitis by low temperatures
Authors: Tokmakova S. I. , Ul’ko T. N. , Bondarenko O. V. , Sysoyeva O. V. , Voblova T. V. , Starokozheva L. Yu.
Published: June 2020

The efficiency of treatment of herpetic stomatitis by autonomous porous titanium nickelide applicators with the use of liquid nitrogen was assessed. In 43 patients, the Hossley-Bergman pain index and erosion epithelization terms after the cryo treatment compared to traditional methods were taken into account. The developed treatment method is characterized by the simplicity, low cost, absence of contraindication and side effects.
Pulp electroodontometry at secondary dentoalveolar deformations
Authors: Ivanov V. A. , Karsanov V. T. , Maslov I. A. , Zheleznyi S. P. , Isayeva T. N.
Published: June 2020

The state of the nervous-receptor apparatus of teeth without opposing teeth was studied with the aid of electroodontometry. Patients were divided into three groups depending on clinical manifestations of teeth without opposing teeth. In each group, electroodontometry of the teeth was carried out. The results obtained are indicative of morphological changes in the nervous-receptor apparatus of teeth without opposing teeth and without the mastication load.
Vertebral artery hypoplasia and cerebral blood flow in patients with acute and chronic disorders of cerebral circulation
Authors: Druzhinin D. S. , Pizova N. V.
Published: June 2020

To assess peculiarities of cerebral blood flow in patients with hypoplasia of vertebral artery, 100 patients were examined. Patients after acute ischemic stroke, chronic ischemic diseases, and a group of healthy patients were separated. In patients with acute ischemic stroke, a reliable decrease was found in the degree of blood flow increment in the posterior cerebral artery at rhythmic photostimulation, as well as in the total volume blood flow in the vertebral-basilar basin.
Constitutional factors and risk of brain stroke development in women
Authors: Kukhareva I. N. , Doronin B. M.
Published: June 2020

Morphofunctional characteristics were examined in old and middle-age women with ischemic stroke. The severity of the disease has been shown to be explained by the age-dependent deficiency of estrogen as one of risk factors.
The role of γδТ- and NK-сells in immune response
Authors: Churina Ye. G. , Urazova O. I. , Novitsky V. V. , Naslednikova I. O. , Voronkova O. V.
Published: June 2020

The article presents up-to-date literature data on the role of γδТ-cells and different NK-cells subpopulations in the immune response. Their origin, immunophenotypes, range of secreted cytokines as well as effector functions and factors having stimulating and inhibitory effect on γδТ- and NK-cells are described. Mechanisms of antibacterial action of this type of cells are analyzed.
Сomparative morphological characteristics of activity score and fibrosis stage in chronic viral hepatitis C
Authors: Purlik I. L. , Perelmuter V. M. , Beloborodova Ye. V. , Beloborodova E. I.
Published: June 2020

A comparison of degrees necroinflammatory activity and fibrosis stages in 433 biopsy specimens of patients with chronic viral hepatitis C (monoinfection and in combination with drug abuse, alcoholic disease, chronic opisthorchosis). Found that ethyl alcohol is the greatest character weights of alteration and severity of multiple sclerosis with HCV-infection. Drug abuse enhances fibrosis in the liver, but no histological activity, and only in comparison with mono-HCV infection. Opisthorchosis defines weakly expressed necroinflammatory and sclerotic changes with (by) HCV-infection.
Network medical organizations: development strategy of and management peculiarities
Authors: Bobrovsky A. V.
Published: June 2020

Advantages provided by network solutions in medicine are now being recognized at all management levels owing to the set of new possibilities, which can be reduced for simplicity to three key principles, namely, the presence of common information resources, replication of valid data from a common center, consolidation of data and information in a common center. Many network clinics using brand management technologies in their marketing strategies have achieveв significant success, which allows this version of strategy to be considered as optimal one.
Inflammatory regenerative processes dynamics with corneal ulcer against the background of usage of blood autologous mononuclear leukocyte
Authors: Zapuskalov I. V. , Krivosheina O. I. , Levchenko N. A.
Published: June 2020

In the experiment in vivo the mechanisms of the development of inflammatory regenerative processes with corneal ulcer against the background of the instillations of blood autologous mononuclear leukocyte and traditional pharmacotherapy are studied. It is determined that against the background of the use of blood autologous mononuclear leukocyte the duration and the intensity of inflammation reduce and the clearance of ulcer defect from necrotic mass accelerates. The instillations of blood autologous mononuclear leukocyte against the background of traditional pharmacotherapy of experimental corneal ulcer stimulate fast change of cell phases in the inflammation center and activate the process of regeneration of damaged cornea structures.
Possibilities of application of low-frequency contact conductometry to study of the functional state of the hemostatic system
Authors: Sorokozherdiyev V. O.
Published: June 2020

Contact conductometry reflects changes in the functional state of the hemostatic system and provides the highly reliable information about the functional interaction of all chains of the hemocoagulation cascade as a whole.
Research of emotional personal sphere and coping strategies of persons with epilepsy
Authors: Karavayeva Ye. V. , Ostrovskaya A. V. , Katayeva N. G.
Published: June 2020

This work is devoted to identifying the relationship between disorders of emotional personal sphere of persons with temporal lobe epilepsy and their preferred coping strategies. The objects of the study were 40 people, including 20 patients with verified diagnosis of temporal lobe epilepsy who are treated at the neurological clinic of the Siberian State University. Clinical and psychological method of research included: the study of neurological status, multivariate Personality Inventory FPI, a scale assessing the level of situational anxiety, C. Spielberger and Y. Khanin, research methods coping strategies A. Lazarus. The results obtained in the present study results confirm the need for early detection of affective spectrum disorders in patients with temporal lobe epilepsy. Because of their availability and high levels of lead to a change in methods of coping with stress, this in turn leads to restrictions in the social sphere.
Territorially distributed system for follow-up care and monitoring of the health status of children with neurological disorders living in remote areas of the Tomsk Region
Authors: Sizov Ye. Ye. , Karas S. I. , Deyev I. A. , Kamaltynova Ye. M.
Published: June 2020

A unified simulation language has been used to develop the structurally functional model of the territorially distributed information system for follow-up care and monitoring of the health status of children with neurological disorders living in remote areas of the Tomsk Region. With this model and structured programming methods, client-server technologies along with the structured query language allow the development of the on-line information-analytical system, which uses the common information space and accumulates data on children with neurological disorders.
Bladder tuberculosis: therapy and surgery
Authors: Kulchavenya Ye. V. , Kholtobin D. P. , Brizhatyuk Ye. V.
Published: June 2020

Bladder tuberculosis is one of the most serious complication of nephrotuberculosis. Efficiency of current therapy is 42.1% only; it was a reason for creation of new scheme of etiopathogenetic therapy and surgical treatment. 63 patients were enrolled in study: 1st group received standard therapy and 2nd — modified. 9 patients from control group were operated with creation of neobladder. Results of therapy for patients treated with levofloxacin and trospium chloride were twice higher than after standard.
Possibilities of transabdominal ultrasonography in the diagnosis of the pediatric gastroesophageal reflux disease
Authors: Balagansky D. A. , Koshel A. P. , Vrublevskaya M. L.
Published: June 2020

The purpose of the current research is to investigate the diagnostic value of ultrasonography of the pediatric gastroesophageal reflux disease. There were 29 children examined with clinical and endoscopic signs of gastroesophageal reflux in each of three age categories: less than 1 year, 1—6 years, and 7—14 years. The examination of abdominal esophagus, stomach and duodenum was conducted with the ultrasound scanner Ultrasonik. The abdominal esophagus was measured from its entrance into the diaphragm to the base of gastric folds. We also measured the diameter of esophagus, the width of lumen, thikness and structure of wall, and the His's angle. The most freqent symptoms of gastroesophageal reflux were the enlargement in diameter of esophagus and the thikening of abdominal esophagus wall, which were observed in 75,9% and 82,8% of cases correspondingly. It was noted that the enlargement of abdominal esophagus lumen happens on an empty stomach and after exercising in water in 44,8% of cases. 37,9% of children with gastroesophageal reflux have His's angle of 90 degrees. Gastroesophageal reflux was registered in 27,6% of cases. If children ranging in older age have enlargement in diameter of esophagus and the thikening of abdominal esophagus wall, it is the evidence of the incompetence of cardia and reflux esophagitis. Neonates with the syndrome of posseting are observed to have insignificant extention of abdominal part of esophagus (equal to 6—7 mm), it may be regarded as morphofunctional immaturity of lower esophagus sphincter.
Multifactor clinical-laboratory valuation of endogenic intoxication in chronic hepatitis B
Authors: Khokhlova N. I. , Tolokonskaya N. P. , Pupyshev A. B.
Published: June 2020

For the determining of the role of clinical data and integral laboratory indices in the valuation of endogenic intoxication (EI) in chronic hepatitis B (HHB) 100 patients and 20 healthy adults were examined. The present symptoms of the disease and the facts about the character and communication of somatic diseases were studied and the effective concentration of albumin (ECA) and the reserve of albumin binding (RAB) were defined by fluorescence method twice at 18—20 days interval. The lowering of average indices of ECA and RAB was revealed in HHB patients in comparison with control group (p < 0,05), and this lowering was stable during the treatment. ECA and RAB levels reducing was more marked in HHB patients with negative changes of acute infectious diseases character and in patients with definite chronic somatic diseases in comparison with the opposite groups (p < 0,05).
Molecular markers of an inflammation in bronchial contents at various phenotypes of a serious bronchial asthma
Authors: Gereng Ye. A. , Sukhodolo I. V. , Pleshko R. I. , Ogorodova L. M. , Selivanova P. A. , Kobyakova O. S. , Dzyuman A. N.
Published: June 2020

The complex immunologic estimation of inflammatory reactions in bronchial contents at 30 patients with various phenotypes of a serious bronchial asthma is spent. It is established that the population structure of lymphocytes and cytokines a profile of the induced phlegm reflects expression and character of inflammatory disturbances in respiratory tracts that will allow to use the given non-invasive method for revealing of molecular markers of serious forms of a bronchial asthma. At the serious terapevticheskirefractory form of a bronchial asthma «brittle» a phenotype in respiratory tracts total СD4+ -, СD19+ -cell and concentration interleukina-4 against depression interleukina-10 is enlarged. At the serious form of a bronchial asthma of a phenotype «the chronic asthma with the fixed bronchial obstruction» in a bronchial secret prevails CD8+ -lymphocytes, concentration interleukina-8, the transforming growth factor-β increases.
Current neuroimaging modalities in differential diagnosis of radiation-induced brain injury in patients with brain tumors
Authors: Skvortsova T. Yu. , Brodskaya Z. L. , Savintseva Zh. I.
Published: June 2020

Differentiation of tumor recurrence from radiation-induced brain changes is the main challenge of neuroimaging in patients with treated cerebral tumor. The review presents the limitations of structural imaging and additional opportunities of perfusion imaging techniques, proton magnetic resonance spectroscopy and positron emission tomography in discriminating recurrent tumor from radiation injury.
Dynamics of clinical-laboratory markers of cholestasis on the ursosan therapy in patients with organic abnormalities of the bile-excreting tracts drainage function
Authors: Korkin A. L. , Ugorelova Ye. A.
Published: June 2020

Study of the ursosan therapy influence on the efficiency of the surgical resolution of cholestasis in the early postoperative period on the bile-excreting tracts. 19 healthy people and 24 patients with organic abnormalities of the drainage function of the bile ducts are examined. The analysis of the clinical, laboratory and instrumental criteria of cholestasis is carried out in the tested groups before and after ursosan’s therapy and the surgical treatment. Ursosan’s prescription leads to 3 times increase of cases of full regression of clinicolaboratory markers of cholestasis during the first week of the surgery on the bile ducts. The ursosan’s therapy should be prolonged more than 8 days after operative restoration of the bile passage on the bile ducts considering high level of lithogenic factors of C bile on these patients as compared to healthy people. The criteria of the completed ursosan’s therapy can be the normalization of the conjugated bilirubin level in the serum and or relief of slagging effect according to the ultrasound results of the bile ducts and a gallbladder.
Surgical treatment of keeled chest in children using titanium nickelide materials
Authors: Maslikov V. M. , Slizovsky G. V. , Gyunter V. E. , Titov M. V. , Kuznetsov Ye. V. , Kuzhelivsky I. I.
Published: June 2020

The article reflects principles of surgical treatment of keeled chest. It describes an operative approach depending on the deformity kind. The work provides analysis of surgical treatment of 26 patients. There were presented main stages of new technique, which supplement the “classical” kind of surgical intervention. It was noted that using titanium nickelide plates with the shape memory to correct keeled chest in children and adolescents is the method of choice and brings good clinical results.
Molecular aspects of the T-helpers type 17 functioning
Authors: Kologrivova I. V. , Kologrivova Ye. N. , Suslova T. Ye.
Published: June 2020

The article presents up-to-date data on the functioning of the T-helper type 17 (Th17). History of the Th17 discovery, transcription factors, mechanisms, mediating stimulation and inhibition of the Th17 differentiation, are described. Cytokines, which are produced by this lymphoid subset, and signaling pathways, through which its effects are realized, are listed. A brief description is given of the main physiological processes and diseases, in which participation of the Th17 was described.
Pathogenetic mechanisms of Valsalva retinopathy development
Authors: Pushkaryova L. D. , Zapuskalov I. V.
Published: June 2020

The purpose of this review was to analyze existing data in the literature research on some pathogenetic mechanisms of the Valsalva retinopathy development. The main causes of retinal vessel damage of vascular are described. They include arterial pressure and central venous pressure elevation. The latter is transmitted to retinal veins and may cause retinal capillar wall ruptur.
Experimental histochrome's effect on the renal excretory function
Authors: Talalayeva O. S. , Zharikov A. Yu. , Fedoreyev S. A. , Zverev Ya. F. , Bryukhanov V. M. , Mishchenko N. P. , Lampatov V. V.
Published: June 2020

The aim of present investigation was to establish possible histochrome's effect on the renal excretory function. During 10 days was being administrated histochrome by subcutaneous injections in dose 10 mg/kg. Every 2 days was being detected daily renal excretions of water, creatinin, sodium and potassium. Long-term histochrome's administration was followed by a fivefold increasing of water excretion and comparable amplification of creatinin. Sodium's and potassium's excretions were increasing to a lesser degree. The revealed histochrome's diuretic effect qualitatively reminds action of diuretic plants, but quantitatively it was compared with thiazid's one.
The image of the ideal pharmacist in the opinions of the pharmaceutical students
Authors: Volchansky M. Ye. , Вrel' A. K. , Boluchevskaya V. V. , Klochkova Ye. A.
Published: June 2020

We have investigated the opinions of the pharmaceutical students about the qualities and character traits of ideal pharmacist and the definition of their self-esteem of this image. The students have noted the most important qualities as professionalism, competence, education and responsibility. Only 28% of respondents have identified full compliance of the chosen specialty.
About necessity of new speciality introduction for pharmacists
Authors: Kutyakov V. A. , Trufanova L. V. , Salmina A. B.
Published: June 2020

In connection with changes in the pharmaceutical market and in public health services sphere necessity of a new speciality introduction for the pharmacists conducting judicial-chemical (chemical-toxicological) researches in establishments of public health services is proved. The speciality statement «Analytical toxicology» completely corresponds to positions of the Bolonsky Convention of 2003 and prospects of development of pharmaceutical industry.
Efficacy of GLP-1 analog to achieve metabolic control and correction of body weight in patients with type 2 diabetes mellitus
Authors: Saprina T. V. , Gudkova T. K. , Stolyarova V. A. , Martynova S. Yu. , Dudarkova N. G. , Yaroshevskaya T. G. , Kabirova Yu. A. , Pavlenko O. A. , Vorozhtsova I. N.
Published: June 2020

Obesity associated with the enhanced risk of cardiovascular disorders plays a key role in the evolvement and progression of type 2 diabetes mellitus (DM2). Incretin mimetics are the sole class of hypoglycemic agents that not only effectively correct hyperglycemia but also reduce body weight. Exenatide (Byetta, Eli Lilly, USA) is the first drug of this class approved for the use as monotherapy. This paper presents data of clinical studies and owns data on the effectiveness of the drug Byetta in achieving metabolic control and weight correction in patients with type 2 diabetes.
An importance viral factors in the etiopathogenesis and in treatment selection otitis media with effusion in children
Authors: Khulugurova L. N. , Shcherbik N. V. , Chuikova K. I. , Starokha A. V. , Litvak M. M.
Published: June 2020

There were 46 children with chronic otitis media with effusion (OME) under the supervision. After carried out virologic research by immune-enzyme analysis, polymerase chain reaction, metod-immunofluorescence-antitel, prevalence Epstein-Barr virus infection — 41 person (89,1 %), a smaller part children with respiratory syncytial virus — 18 children (39,1 %) and adenovirus infections — 15 children (32,6 %) — are noted. All patients were undergone surgical treatment — middle ear bypass surgery, after the surgery the thirst group patients received antiviral drug while the second group patients received standard treatment. Inclusion antiviral drug into the OME treatment algorithm decreases terms of patient¢s treatment.
The role of intracellular gaseous transmitters hydrogen sulfide and nitric oxide in apoptosis regulation of normal and cancer cells
Authors: Starikova Ye. G. , Ryazantseva N. V. , Novitsky V. V. , Tashireva L. A. , Starikov Yu. V. , Stepovaya Ye. A. , Osikhov I. A. , Vasiliyeva O. A. , Yakushina Y. D.
Published: June 2020

Investigation of influence of gases nitric oxide and hydrogen sulfide on apoptotic cell death of Jurlat cells and mononuclear leucocytes of healthy donors was conducted. It was shown that 100 mmol sodium nitroprussidi increased the apoptosis of T lymphoblast leukemia cells after 15’ incubation. 10 and 100 mmol donor of hydrogen sulfide caused apoptotic death of Jurkat cells after 15’ incubation. 15’ exposure of nitric oxide and hydrogen sulfide donors did not lead to the changes of cell death of mononuclear leucocytes. Gaseous transmitters NO and H2S increased necrosis of Jurkat cells and mononuclear leucocytes after 24 h incubation with the appropriate gase’s donor.
COMORBID CARDIORESPIRATORY PATHOLOGY AND BEHAVIORAL RISK FACTORS: A NEW LOOK AT OLD PROBLEM
Authors: Vasilkova T. N. , Rybina Yu. A.
Published: June 2020

The material for the study included patients with chronic obstructive pulmonary disease (COPD) in association with arterial hypertension (AH) II stage – 50 people. A comprehensive clinical and functional study of the assessment of emotional status. Found that with the increase of the severity of COPD and hypertension increases the frequency and severity of cognitive impairment up to dementia.
METHOD OF LOCAL ADRENAL ORGAN-PRESERVING CRYOLYSIS. EXPERIMENTAL STUDY
Authors: Popov O. S. , Gyunther V. E. , Dambaev G. Ts. , Latypov V. R. , Geydarov R. Ya. , Galyan A. N.
Published: June 2020

A method of local adrenal organ-preserving cryolysis using a porous nickelide titanium cryoprobe created for this purpose was developed in experiments in 14 dogs. The efficacy of the method was demonstrated by the morphological evidence and hormone tests.
NEURODYNAMIC AND PREDICTABILITY OF ALPHA-STIMULATING BIOFEEDBACK COURSE IN SPORTSMEN AND PERSONS OCCUPYING PHYSICAL CULTURE
Authors: Cherapkina L. P. , Tristan V. G. , Styopochkina S. P.
Published: June 2020

The 15-days neurofeedback course was conducted with the purpose of neurodynamic and predictability assessment of mastering of arbitrary regulation skill of electroencephalographic (EEG) spectral power in alpha-band in sportsmen (n=260) and persons (n=69) occupying physical culture. The electroencephalographic parameters being predictors of neurofeedback course were defined in result of research. It was showed that different neurodynamical changes in examined groups supported training successfulness.
PSYCHOPHYSIOLOGICAL CHARACTERISTICS OF WOMEN IN DEPENDENCE ON THE OVARIOHORMONAL CYCLE PHASE AND PROGESTERONE ACTIVITY (PART 1)
Authors: Muravlyova K. B. , Kuzminova O. I. , Petrova S. E. , Skoraya M. V. , Bazanova O. M.
Published: June 2020

With the aim to identify the effects of menstrual cycle phase on the cognitive and psycho-emotional characteristics in 78 women aged 18–27 years were studied in a within-subject design Half the subjects began during their follicular phase and half began during their luteal phase (LP). The level of psycho-emotional tension was lowest, but cognitive performance efficiency is a highest in LP that is associated with the highest saliva progesterone level.
BRAIN-COMPUTER-INTERFACE – SUPPORTED MOTOR IMAGERY TRAININTG FOR PATIENTS WITH HEMIPARESIS
Authors: Mokienko O. A. , Bobrov P. D. , Chernikova L. A. , Frolov A. A.
Published: June 2020

The aim of study was to assess the feasibility of motor imagery supported brain-computer interface in patients with hemiparesis. 13 patients with central paresis of the hand and 15 healthy volunteers were learning to control EEG-based interface with feedback. No differences on interface control quality were found between patients and healthy subjects. The trainings were accompanied by the desynchronization of sensorimotor rhythm. In patients with cortical damage the source of EEG-activity was dislocated.
CONTACTLESS MEASUREMENT OF KEY PARAMETERS OF LIMB VESSELS ON AN OCCLUSAL PLETHYSMOGRAPHY METHOD
Authors: Kuznetsov V. I. , Tarakanov S. A. , Ryzhakov N. I.
Published: June 2020

The purpose of this publication – to familiarize the readers with the newest achievements in the field of vision   machine   technologies   with   regard to the   occlusal   plethysmography.   The   principle   of plethysmograph work is similar to a principle of mechanical occlusal plethysmograph work, with that only a difference that working measuring environment (gas or liquid) is replaced with laser labels, and fixation of change of volume is made by machine vision with the subsequent computer processing. Application of laser technologies of machine vision in future considerably simplified process of diagnostics, will allow to carry out diagnostics repeatedly and under various conditions of, for example, case of external action on the examined finiteness of the of heat, cold, physical exercise, and so, is representative of more and accurate picture of the state of blood vessels in the dynamics.
ENDOTHELIAL PROTECTIVE EFFECTS OF KLYMADINON IN EXPERIMENTAL OVARIECTOMY
Authors: Anishchenko A. M. , Plotnikova T. M.
Published: June 2020

A Endothelial protective and antithrombogenic effects of Cimicifuga racemosa standardized extract (Klimadynon, Bionorica, Germany) in comparison with ethinylestradiol in experimental ovariectomy were investigated. Extract of Cimicifuga racemosa (klimadynon) contents phytoestrogens, that was the basis for studying of its effects in hypoestrogenic conditions for the purpose of prophylaxis and treatment of cardiovascular complications in climacteric syndrome as an alternatively of hormonal replacement therapy.The course administration of klimadynon (100 mg/kg p.o. daily during 14 days) decelerated the formation of intravascular thrombosis which was initiated by application of 10% FeCb solution on carotid artery. The ethinylestradiol in this conditions intensified prothrombogenic effect of application of 10% FeCh: blood flow in carotid artery stoped to 5 minutes of experiment and mass of the thrombus was on 28% more, than in control rats. For studying of possible mechanisms antithrombogenic action of klimadynon antiplatelet and vasodilator activity of endothelium were studied in rats after bilateral ovariectomy in comparison with effects of ethinylestradiol (25 µg/kg p.o. daily during 14 days). Treatment with klimadynon as well as ethinylestradiol increased the antiplatelet activity of endothelium, restoring its activity to level in sham-operated animals. The endothelium-dependent and endothelium-independence vasodilation by using of acetylcholine (5 µg/kg) and of sodium nitroprusside (30 µg/kg). respectively, were investigated. Coefficient of endothelium dysfunctions (CED) was estimated as ratio: area over curve of arterial pressure after sodium nitroprusside intravenous injection to value of this index after injection of acetylcholine. In rats after bilateral ovariectomy CED was increased by 66% in comparison with CED value in sharm-operated rats. The klimadynon and ethinylestradiol treatment decreased CED on 42% and 28% correspondingly in comparison with values of control group.In summary klimadynon has antytrombogenic and endothelial protective activities in the rats after ovariectomy. The ethinylestradiol decreases endothelial disfunction in ovariectomized rats, but unlike klimadynon demonstrates protrombogenic effect. The present findings suggest that klimadynon could be used as a therapeutic agent for menopausal vascular complication.