bluuebunny/crossref_metadata_2025 huggingface dataset:
PRESERVING HERITAGE THROUGH NEW NARRATIVES: DESIGNING A GUESTHOUSE WITHIN A CROSS-DISCIPLINARY TEAM
Authors: Bandeira Maia Pedro , Pinto Raul
Published: December 2020

The following article describes the ongoing interior design project that accommodates a guesthouse in a historical building located in the city of Coimbra in Portugal. It focuses on the importance of generating new narratives to maintain the original nineteenth century building’s essence, when changing the architectural program, from a pharmacy on the ground floor and residences in the upper floors into a single guesthouse.
We present the design-led methodology focused on the importance of generating narratives as a foundation to achieve a common goal while working in a cross-disciplinary team. In this context, the designer not only has the role of the form-giver, but also becomes the mediator between matter and form, the team leader, and the forecaster of the user’s emotional experiences.
When adapting client’s brief into a tangible outcome within a team that crosses various areas of expertise (in this case: architecture, design, engineering, archaeology, conservation, and restoration), the importance of generating an open concept that can adapt to the evolving context, becomes key to meet client’s expectations. This article intends to contribute to the discussion of the designer’s elastic mindset as a binding tool between actors and contexts, towards an outcome that acknowledges the importance of the contribution of each one when looking for enriched results. Therefore, it questions what is gained and what is lost by setting aside the classic design fundamental principles and by focusing on design as a managing tool between data and the involved actors for an enriched outcome.
As a main conclusion, it underlines the importance of generating a strong narrative with an open outcome to bind all stakeholders to a common goal through the designer as a project leader.
Procedures for auditing the cost of dairy production
Authors: Safonova M.F. , Mamushkina N.V.
Published: December 2020

Subject. This article discusses the issues related to the audit procedures required for auditing, taking into account the specifics of production technology and production costs.
Objectives. The article aims to unify the audit procedures for cost accounting and cost calculation, taking into account the specifics of the production process, which directly affect the verification methodology and technology of the audit job. The article also aims to formulate specific audit procedures for accounting for the cost of dairy production, taking into account the specifics of the process of obtaining finished products.
Methods. For the study, we used the methods of analysis and synthesis, induction and deduction, and information classification and consolidation techniques.
Results. The article presents audit procedures for the production of dairy cattle products, which are carried out taking into account the specifics of the production technology and business process, the specifics of the organization and accounting of costs and the formation of reporting of the audited economic entity.
Conclusions and Relevance. The application of audit procedures is due to the peculiarities of accounting and consists in the consistency of these procedures and the use of sources of information. Audit procedures carried out during the audit of the costs of dairy production contribute to the identification of accounting and reporting errors and misstatements. They are a source of audit evidence to form the auditor's opinion. The results of the study can be used in audit theory and in the practical activities of auditors and audit organizations.
Conversion of heavy gasoil into ultra-low sulfur and aromatic diesel over NiWRu/TiO2–γAl2O3catalysts: Role of titanium and ruthenium on improving catalytic activity
Authors: Prada Silvy Ricardo , Lageshetty Sathish Kumar
Published: December 2020

This contribution deals with about selective conversion of heavy gas oils into middle distillates fuels that meet ultra-low sulfur and aromatic compound quality standards by using a novel NiWRu/TiO2–γAl2O3catalyst under typical hydrotreatment conditions. A diesel fuel fraction having sulfur, nitrogen and aromatics compound content of about 50 ppm, 10 ppm and 15 v%, respectively, was obtained when the reactor was operated atT = 370 °C,P = 12.4 MPa, LHSV = 0.5 h−1and H2/hydrocarbon ratio = 800 Nm3/m3. Titanium and ruthenium additives used in the preparation of the NiWRu/TiO2–γAl2O3catalyst, remarkably improved the catalytic activities for the hydrogenolysis, hydrogenation and hydrocracking reactions compared to the reference NiW/γAl2O3catalyst. The coprecipitation of titanium and aluminum hydroxides produced a catalyst support having greater surface area, pore volume and surface acidity. An improvement in mechanical properties of the support extrudates was also observed. Characterization analysis by XPS, AUGER and XRD techniques of the TiO2–γAl2O3support suggested the formation of an aluminum-titanate mixed phase (AlxTiyOz) having a non-well-defined stoichiometry. The NiW/TiO2–γAl2O3and NiWRu/TiO2–γAl2O3exhibited a greater surface dispersion of the supported nickel and tungsten species compared to the NiW/γAl2O3catalyst. The promoter effect of ruthenium on the NiW bimetallic system caused a strong increase in both hydrogenolysis and hydrogenation reactions. Hydrodenitrogenation and hydrocracking reactions were also favored by the increase in the hydrogenation capacity and in the surface acidity of the catalyst. The highest conversion levels for all investigated reactions were obtained when the NiWRu/TiO2–γAl2O3catalyst was prepared by co-impregnation of Ni and Ru in a second step. This catalyst showed sulfur tolerance properties when the reaction was conducted in the presence of different H2S partial pressures. The catalytic behavior of the NiWRu/TiO2–γAl2O3catalyst was explained by the existence of a promoting effect between separated Ni and Ru sulfides species and the NiWS phase (dual mechanism).
Dissolving Pulp dari Kayu dan Nonkayu: Tinjauan Proses Pembuatan dan Karakteristiknya
Authors: Biantoro Reynaldo , Septiningrum Krisna , Kardiansyah Teddy
Published: December 2020

Pemanfaatan derivat selulosa menjadi viskosa rayon saat ini berkembang secara signifikan; dalam hal ini pulp khusus yang digunakan adalah dissolving pulp. Dissolving pulp ini memiliki karakteristik tertentu seperti kandungan selulosa tinggi (> 90%), kadar hemiselulosa rendah, lignin dan kandungan ekstraktif (kurang dari 10%), reaktivitas selulosa tinggi dengan tingkat distribusi berat molekul dan kecerahan tinggi, serta memiliki viskositas sekitar 200-300 dm3/kg. Saat ini, pembuatan dissolving pulp diarahkan untuk penggunaan bahan baku kayu dan non-kayu yang melimpah dengan menggunakan metode ramah lingkungan. Secara umum terdapat empat metode utama termasuk teknologi konvensional dan terbaru yang dapat digunakan untuk membuat dissolving pulp seperti: 1. Metode bisulfit menggunakan gas SO2 dengan yield sekitar 55 -75%; 2. Metode sulfit-soda yang mampu menghasilkan kandungan selulosa yang tinggi (hingga 96%); 3. Pra-hidrolisis kraft yang merupakan metode populer dalam pembuatan dissolving pulp dan 4. Konversi pulp kertas menjadi dissolving pulp. Dalam makalah ini dibahas pembuatan dissolving pulp menggunakan enzim seperti xilanase dan mono komponen endoglukanase dan kombinasi antara mekanik, kimia dan metode enzimatik. Kata kunci: dissolving pulp, pra-hidrolisis kraft, enzim, konversi pulp kertas
Structural Determinants for the Mode of Action of the Imidazopyridine DS2 at d-containing g-Aminobutyric Acid Type A (GABAA) Receptors
Authors: Frølund Bente , Rostrup Frederik , Falk-Petersen Christina Birkedahl , Harpsøe Kasper , Buchleithner Stine , Conforti Irene , Jung Sascha , Gloriam David E. , Schirmeister Tanja , Wellendorph Petrine
Published: December 2020

A SAR study of the delta-selective positive modulators DS2 was performed to assist the quest for the binding site. The modulatory effect was measured using a fluorometric inaging plate reader (FLIPR) membrane potential (FMP) functional assay. Specific positions in the structural scaffold of DS2 was found to severly affect the pharmacological profile.

Analogs superior to DS2 were identified displaying higher potency and selectivity for the alfa4beta1delta over alfa4beta1gamma.
CLÍNICAS DE DIREITO: DINAMIZANDO O ENSINO APRENDIZAGEM NOS CURSOS DE DIREITO
Authors: Malosso Tiago Felipe Coletti , Dos Santos Gabriel Ludwig Ventorin
Published: December 2020

Partindo de uma abordagem teórico-reflexiva inspirada no método dedutivo, propõe-se a análise da aplicabilidade das clínicas de direito pelos cursos de Direito, especialmente tendo em conta a realidade das instituições privadas de ensino superior. Delineia os conceitos de metodologia ativa e clínicas de direito e revisando as principais normas estatais que tratam dos cursos de Direito no Brasil. Após levantarem-se as vantagens e ressalvados os riscos mercadológicos, conclui-se pela plena viabilidade de sua utilização que pode provocar efetiva emancipação dos alunos e alunas dos cursos de Direito no Brasil e fortalecimento da cidadania no país.
A COVID-19 E O INTERVENCIONISMO JUDICIAL: A DECRETAÇÃO DE LOCKDOWN NA REGIÃO METROPOLITANA DE SÃO LUÍS-MA POR MEIO DE DECISÃO JUDICIAL
Authors: LIMA DA SILVA MORAES ANNE HARLLE , SILVA DE SEIXAS BERNARDO , CARVALHO MARQUES DOS SANTOS BRUNO
Published: December 2020

Este trabalho tem o escopo de abordar juridicamente a forma como o Estado brasileiro vem enfrentando a pandemia de Covid-19. A delimitação da temática analisará a decisão judicial que determinou a implementação da política pública de isolamento social denominada de lockdown na região metropolitana e em São Luís, capital do Estado do Maranhão. A problemática que orienta o trabalho é se o Poder Judiciário pode determinar políticas públicas de isolamento social durante o período de calamidade pública da Covid-19. O objetivo principal é demonstrar como são resolvidos os conflitos entre os poderes para implementação de políticas públicas durante a pandemia.
A BIOECONOMIA NO SÉCULO XXI: REFLEXÕES SOBRE BIOTECNOLOGIA E SUSTENTABILIDADE NO BRASIL
Authors: Bazán Barba Romina Ysabel , Dos Santos Nivaldo
Published: December 2020

Aborda-se, dentro do direito e sustentabilidade, pela vertente jurídico-sociológica, a problemática da Bioeconomia no Século XXI. Com base na dedução da pesquisa teórica, estuda-se como a biotecnologia vem assumindo a liderança entre os setores industriais e os novos desafios dessa economia que representa o futuro da humanidade. Objetiva-se analisar como a biotecnologia trará mais benefícios de ordem social, ambiental, econômico e cultural. Traçando-se um panorama das tendências atuais para os setores da saúde, energia (biocombustíveis), agricultura, alimentos e conservação dos recursos biológicos. Além disso, sua proteção, regulamentação e aplicação para o futuro no Brasil.
Legitimidade de acesso à reprodução assistida post mortem (RAPM)
Authors: Ribeiro Raphael Rego Borges
Published: December 2020

Neste artigo, investigamos quem é legitimado para proceder à reprodução assistida post mortem. Questionamos se apenas o cônjuge ou companheiro(a) supérstite pode utilizar os gametas criopreservados. Procedemos a consulta bibliográfica e normativa, usando o método dedutivo. Observamos que o elemento fundamental para o acesso à RAPM é o consentimento do(a) falecido(a). Concluímos que a legitimidade para a RAPM independe: (a) do estado civil de quem congelou material genético; (b) do estado civil de quem quer acesso póstumo ao material germinativo; (c) de ter havido vínculo de casamento ou união estável entre o(a) morto(a) e quem quer usar os gametas criopreservados.
PRECISAMOS FALAR SOBRE A BIOÉTICA E A BIOIMPRESSÃO DE ÓRGÃOS 3D
Authors: Lima Daniela Nicolai  de Oliveira
Published: December 2020

O artigo aborda o problema referente à fila de espera por transplantes de órgãos no Brasil e propõe como solução a bioimpressão de órgãos 3D. O professor italiano Stefano de Rodotá aprofundou-se na bioética e nas teorias do transumanismo e do pós-humanismo, afirmando que o homem desenvolverá suas capacidades físicas e mentais, com o auxílio da ciência, para um novo patamar de evolução antropológica. Assim, deve respeitar-se o seu direito de autodeterminação, sobre seu corpo e sua existência, com base no princípio constitucional da dignidade da pessoa humana. A metodologia é indutiva, através da pesquisa bibliográfica qualitativa, pela via eletrônica.
A repartição e a destinação da receita das custas judiciais quinze anos após a Reforma do Judiciário
Authors: Carneiro Leão Farias Guilherme
Published: December 2020

O objetivo do presente artigo é determinar, em 2020, o estágio de efetivação da vinculação da receita de custas judiciais exclusivamente ao custeio dos serviços afetos às atividades específicas da Justiça. Esse objetivo foi perseguido por meio de pesquisa descritiva e quantitativo-qualitativa, baseada em coleta de dados legislativos e em revisão de literatura. Os resultados obtidos indicam que 13 dos 27 entes federativos competentes para arrecadar essa receita tributária descumprem essa vinculação constitucional (48,15%). Dessa forma, conclui-se que o grau de efetivação da regra do art. 98, § 2º, da CRFB ainda é insatisfatório.
A ANÁLISE ECONÔMICA DO DIREITO APLICADA À TRIBUTAÇÃO COMO FORMA DE CONCRETIZAÇÃO DOS DIREITOS FUNDAMENTAIS
Authors: Assunção Sousa Vithor , Paes Nascimento Hérica Cristina , Cristina Garcia Cabral Valéria
Published: December 2020

A Análise Econômica do Direito (AED) tem-se se mostrado um campo de análise para a promoção da justiça e efetivação das garantias fundamentais consagradas num Estado Democrático de Direito, notadamente frente às novas tecnologias. Essa ferramenta do Direito também se mostra eficiente na busca pela máxima aplicabilidade dos direitos fundamentais, a partir da observância de um comportamento tributário mais eficiente, capaz de conferir a máxima concretude aos preceitos constitucionais abstratos. Objetiva-se no presente artigo trazer reflexões acerca da concretização dos direitos fundamentais sob a ótica da Análise Econômica do Direito aplicada à tributação.
O AUXÍLIO MORADIA CONCEDIDO AOS MEMBROS DA MAGISTRATURA: UMA ABORDAGEM A PARTIR DO PRINCÍPIO DA IGUALDADE
Authors: GOMES JESUS TUPÃ SILVEIRA , GRACIOLLI LUCAS UELINTON
Published: December 2020

Em 2014, o CNJ criou o auxílio-moradia em favor dos magistrados, o que supostamente contraria o princípio da igualdade previsto na Constituição Federal de 1988. O objetivo do presente estudo consiste em aferir, com fundamento no constitucionalismo garantista e no Direito da Antidiscriminação, se ele está em conformidade com o Direito pátrio. Assim, examinamos o princípio da igualdade, mapeamos as prerrogativas concedidas aos grupos vulneráveis e analisamos a conformidade do benefício com o ordenamento vigente. Realizamos pesquisa documental, com a revisão da bibliografia, utilizando o método hipotético-dedutivo. Os resultados indicam que o auxílio-moradia contraria o princípio da igualdade.
A LIBERDADE DE EXPRESSÃO E O CRIME DE DESACATO À LUZ DO SISTEMA INTERAMERICANO DE DIREITOS HUMANOS
Authors: Dias Fonseca Maria Eduarda , Terezo Ribeiro Cristina Figueiredo
Published: December 2020

Diante da importância do direito à liberdade de expressão para a consolidação de uma sociedade democrática, sobretudo no que diz respeito ao controle democrático das atividades estatais, tem-se a necessidade de se discutir acerca dos entendimentos relativos a este direito e as formas de sua restrição. Neste sentido, a proposta do presente artigo é de estudar os entendimentos da Corte Interamericana de Direitos Humanos no que diz respeito à liberdade de expressão, para em seguida observar se o crime de desacato tipificado na legislação brasileira se enquadra nos requisitos das restrições permitidas pelo Sistema Interamericano.
CRIMINOLOGIA VERDE, ABUSO ANIMAL E TRÁFICO NO BRASIL: REGULAÇÃO PENAL DEFICIENTE NA PROTEÇÃO EFETIVA DO MEIO AMBIENTE
Authors: Ribeiro Luiz Gustavo Gonçalves , Calhau Lélio Braga
Published: December 2020

O artigo analisa, sob a ótica da criminologia verde e do direito penal ambiental, a deficiência da legislação penal brasileira no tocante ao tráfico de animais, e tem por escopo alertar o leitor para a gravidade da conduta que atenta conta a dignidade animal e para a omissão do legislador na tipificação da conduta. A pesquisa é de cunho bibliográfico e o método é o lógico-dedutivo.
AMPLA DEFESA E CONTRADITÓRIO: ANÁLISE DA PRECLUSÃO NO VIGENTE SISTEMA PROCESSUAL
Authors: Gomes Junior Luiz Manoel , França Lange Junior Edison
Published: December 2020

No presente artigo, busca-se desenvolver a noção do sistema preclusões à luz dos princípios do contraditório e ampla defesa, mediante uma análise da função dos institutos voltada ao processo justo, avaliando, neste contexto a sistemática da resposta do réu no Novo Código de Processo Civil. Para tanto, fez-se necessário o estabelecimento de uma concepção material do contraditório, analisando os efeitos jurídicos concretos inerentes a essa nova perspectiva. Foi utilizado para a pesquisa o método dedutivo, através da análise bibliográfica e jurisprudencial sobre o tema.
The Impact of Social Distancing Measures on Higher Education Stakeholders
Authors: Pypenko I. S. , Maslov Yu. V. , Melnyk Yu. B.
Published: December 2020

Background and Aim of Study: The global CoVID-19 pandemic has affected education systems dramatically. Remote teaching/learning practices have become everyday reality across the globe. The aim of the study: to assess the level of readiness of higher education stakeholders for distance learning/remote teaching, and to evaluate the role of social distancing measures. Material and Methods: 594 stakeholders (216 teachers and 378 students) provided anonymous responses to a questionnaire. Teacher did so during the round table discussion during the 6th International Academic Conference “Psychological and Pedagogical Problems of Modern Specialist Formation” (June 2020). Students responded using Viber, WhatsApp, and Telegram. Validation by Pearson method χ2 produced statistically significant results (df=4, χ22=22.083, р<0.01; df=4, χ23=44.389, р<0.01; df=4, χ24=29.666, р<0.01). Results: 62.9% of teachers and 56.6% of students consider educational institutions ready for distance learning. The majority of teachers/students seem to be prepared for it (81.0% and 93.4% respectively). 68.5% of teachers are positive about educational outcomes (contrasted with 90.0% of students). Only 37.0% of teachers and 21.7% of students assess the impact of social distancing measures on physical and mental health positively. Conclusions: The survey results prove that social distancing measures impact on higher education is significant. The respondents assess highly their individual levels of preparedness and of satisfaction, students displaying higher levels of both. However, the view on social distancing measures impact on physical and mental health is more negative, the trend being more visible in student responses.
The Electability Level of PDI-P on Social Media of Instagram
Authors: Rachmandani Resky Eka , Purnomo Eko Priyo , Kasiwi Aulia Nur
Published: December 2020

In this era of the 21st century, political parties have many ways to develop a campaign, including on social media as a new medium to do a campaign. Partai Demokrasi Indonesia Perjuangan (PDI-P) has its own strategy toward social media to achieve their power in society. This research aims to discover the level of electability of PDI-P through Instagram, one of social media platforms being used to make social interaction with the public. Starting from Instagram, this research has decided three criteria: basic of election mode, media channels, and technological access to political party that can be seen by public. The analysis is conducted to a variety of large and small media outlets that analyze and explore things beyond political parties. This research uses Nvivo12 Plus as network analysis tools to identify and analyze data from Instagram related to PDI-P strategy. The results of this study show that social media has a significant role in pursuing and maintaining the power of political parties to stay strong in society’s life. This research also develops a novelty, based on the results, that social media has a strong power to build a strategy and accept plurality in society’s behavior, instead of building a strong branding of the political party itself and stand out as candidates.
Measuring IGF-1 and IGFBP-3 profiles in women seeking assisted reproduction; relevance to clinical outcomes from in vitro fertilization (Study 5).
Authors: John L Yovich  , Syeda Zaidi  , Minh DK Nguyen  , Peter M Hinchliffe
Published: December 2020

In this fifth study examining the relevance of the insulin-like growth factor (IGF) profiles, namely serum IGF-1 levels, its main binding protein, serum IGFBP-3 levels and the IGF ratio (IGFBP-3/IGF-1), we have examined clinical outcomes with respect to the quartile ranges of each parameter measured in 1633 IVF-naïve women. The outcomes were derived from 1035 of these women who initiated 1747 IVF cycles. Of the three parameters, only IGF-1 levels proved relevant to the clinical outcomes. In particular, this study confirmed our earlier report that IGF-1 levels decline across the quartiles with the woman’s advancing age and the proportion of women with IGF-1 levels in the highest quartile comprised the younger, whilst those women ≥40 years were mostly in the lowest quartile (p<0.0001). IVF cycle cancellations were not different across the quartiles but at oocyte pick-up (OPU) there were significantly more oocytes from the highest IGF-1 quartile (10.4 oocytes) compared to the lowest (8.9 oocytes; p<0.01). Furthermore, the proportion of oocytes shown to be at the mature MII stage were also significantly higher (p=0.01). Consequently, the oocyte utilization rate was significantly greater from those women with the highest IGF-1 levels generating 5.3 embryos vs 4.3 embryos for the lowest quartile. However, the utilization rate of those embryos generated were similar across the IGF-1 quartiles and there were similar rates of “freeze-all embryos”, albeit more women had increased monitoring for ovarian hyperstimulation risk, related to the higher egg numbers in the highest IGF-1 quartile. The most striking clinical outcomes were that of the pregnancy productivity rate (including fresh and frozen embryo transfers from a single OPU) which was greatest in the highest IGF-1 quartile (61.5% vs 48.2% per OPU across all ages p<0.0002). Miscarriage rates were not different but live birth productivity rates were significantly greatest for the highest IGF-1 quartile (49% vs 33% per OPU across all ages; p<0.0002). We conclude that a preliminary measurement of the IGF-1 level can help to define the poor-prognosis female prior to IVF treatment and on whom adjuvant studies can be focused.
Measuring IGF-1 and IGFBP-3 profiles in women seeking assisted reproduction; response of women categorized as poor-prognosis to recombinant growth hormone adjuvant therapy (Study 4)
Authors: John L Yovich  , Syeda Zaidi  , Minh DK Nguyen  , Peter M Hinchliffe
Published: December 2020

In this fourth study examining the relevance of measuring the IGF profile (IGF-1, IGFBP-3 and the ratio of IGFBP-3/ IGF-1) in women presenting for assisted reproductive technologies (ART), we have examined the influence of recombinant growth hormone (rGH) prescribed as an adjuvant on the profile. Of 1633 ART-naïve women who completed an assessment cycle (AC) workup, and which included an IGF profile, 941 women proceeded to an in-vitro fertilization ± intracytoplasmic sperm injection (IVF±ICSI) treatment cycle during the period January 2011 to December 2019. Among those women, 90 were prescribed rGH because they were classified as likely poor-prognosis cases on the basis of advanced age or evidence of severely reduced ovarian reserve parameters. These women had their IVF±ICSI treatment within 3-months of their AC and consented to a second IGF profile measurement 4-6 weeks during their rGH treatment phase. Of the 90 women prescribed rGH adjuvant, 71 used the adjuvant and 19 deferred the treatment, but still completed the second IGF-profile. The data showed that rGH caused a significant elevation in IGF-1 (p<0.0001) as well as its main binding protein, IGFBP-3 (p<0.001), albeit to a lesser degree. Consequently, the IGF ratio, considered a more reliable marker of IGF-1 activity, was shown to be significantly reduced towards the normal range (p<0.0001). The data of clinical outcomes from these 90 women as well as the entire 941 women entering the IVF±ICSI treatment are presented for comparison, noting these data are not suitable for statistical evaluation as the groupings are disparate and unmatched. Further studies are intended to show the clinical relevance of increasing the IGF-1 levels in the analytical investigation of rGH as an adjuvant in ART.
Computer system validation
Authors: Rusjan Borut
Published: December 2020

The purpose of this paper is to present a Quality Management System (QMS) for computer systems validation and to identify and demonstrate the validation process on a practical case of a pharmaceutical company. Based on the European and the US legal requirements, we define QMS for computer system validation elements. Validation process example based on the use of a general V-model provides a thorough understanding of the actual validation implementation in practice. Computer system validation in a concrete organization can be implemented, based on general and specific standard operating procedures which form the QMS. Planning, Specifying, Development/Building, Verification and Report validation activities are presented through process diagrams based on a practical Supervisory Control and Data Acquisition (SCADA) manufacturing computer-aided system validation example. Empirical part employed two research strategies: a single case study and action research. Presented computer system validation QMS and process can provide a guideline for all companies where computer systems are important. Although the presented QMS and process for the computer system validation are related to a specific pharmaceutical company case and its legal requirements, the experience from this highly regulated industry can be appropriately used in other less regulated industries. For verification of the proposed model, they need to be further tested within the pharmaceutical and other less regulated industries.
A framework for digital transformation and business model innovation
Authors: van Tonder Chanté , Schachtebeck Chris , Nieuwenhuizen Cecile , Bossink Bart
Published: December 2020

With the advent of the Fourth Industrial Revolution, businesses are adapting to the use of digitalisation which requires the digital transformation of their existing business models. However, there is limited empirical research on this phenomenon. The purpose of this study is twofold: (i) to develop a framework for businesses to digitally transform their business models and (ii) to examine literature in order to identify and analyse the constructs underlying the three concepts of Digitalisation, Digital Transformation and Business Model Innovation. The study is qualitative in nature and is based on a narrative review. Relevant articles were identified by using international bibliographic databases and scrutinised using thematic analysis. The findings reveal that the first two constructs require digital capabilities and a digital strategy. The third construct requires digital transformation in the realm of customer-centricity, resources, processes and profit. A set of propositions was formulated and the commonalities were mapped. Based upon this map, a conceptual framework was developed. The findings will assist in the development of future instruments that can guide businesses to digitally transform existing business model elements. This study aims to fill the gap on how business model innovation should be pursued through digital transformation by developing a conceptual framework.
Teleworking in small and medium enterprises (SMEs) before the onset of coronavirus crisis in the Czech Republic
Authors: Vrchota Jaroslav , Maříková Monika , Řehoř Petr
Published: December 2020

Due to the new information and communication technologies, it is now possible to disconnect work from space and time and to take advantage of new ways of organizing work. One of the options is teleworking (TW), currently being implemented throughout Europe due to the condition created by the coronavirus pandemic. The aim of the paper is twofold: (i) to analyse a range of factors (size of the enterprise; foreign owner; written strategy; project-driven enterprise; disabilities; work-life balance; benefits, lack of workers, illness, lower cost, relax at work and comfort; renting space, IT level) influencing the duration of TW implementation in the small and medium-sized enterprises (SMEs) and (ii) to better define the differences between the SMEs where TW was introduced in a short time, and those introducing it over a longer period. Out of the total of 31 factors, six factors have been proved to have a different impact on the duration of TW implementation (TW implementation due to higher efficiency; monitoring is performed only according to the results; the managers see the disadvantage of TW in its possible misuse; the enterprises use internal TW regulations; the managers see the main advantage as higher operational flexibility; the introduction of TW, due to the balance of work and family life). All together, 44,000 SMEs in the Czech Republic were invited into the research. The data were collected from 1,018 enterprises, with 60% of the enterprises using TW actively; on average, these enterprises have been using it for seven years.
Restablecimiento de Aspidosperma quirandy (Apocynaceae) como especie diferente de A. tomentosum y notas sobre su presencia en Paraguay
Authors: De Egea Elsam Juana , Mereles Fátima , Peña-Chocarro María , Céspedes Gloria
Published: December 2020

Se justifica el restablecimiento de Aspidosperma quirandy Hassl. como un taxón diferente de A. tomentosum Mart. Se presentan descripciones actualizadas de ambas especies, junto con una clave para su identificación, observaciones ecológicas y nuevo material de referencia. Se resuelve la tipificación de cuatro nombres descriptos por Hassler basados en material de Paraguay, designando un lectotipo para Aspidosperma quirandy, y efectuando lectotipificaciones de segundo paso para Aspidosperma quirandy var. campestre Hassl., Aspidosperma quirandy var. silvaticum Hassl. y Aspidosperma rojasii Hassl.
La “Materia Médica Misionera” atribuida al jesuita Pedro de Montenegro en 1710 (II): Identificación de las plantas y sus usos contra trastornos del aparato reproductor
Authors: Scarpa Gustavo F. , Anconatani Leonardo M.
Published: December 2020

Se identifican las plantas empleadas para el tratamiento de los trastornos del aparato reproductor mencionadas en la “Materia Médica Misionera” (M.M.M.) atribuida al jesuita Pedro de Montenegro fechada en 1710. Se describen sus indicaciones terapéuticas en su contexto médico histórico de referencia y se discuten las relaciones de estos resultados con la etnobotánica médica folk actual de la zona de las “misiones”. Las identidades de las plantas se estimaron sobre la base de las descripciones textuales y representaciones gráficas extraídas de la fuente de datos, así como de las correspondencias botánicas de los nombres vulgares obtenidas a partir de una búsqueda exhaustiva de las mismas en 59 obras. Un total de 57 taxa empleados contra trastornos del aparato reproductor pudo ser identificado botánicamente, los cuales refieren a 102 datos etnobotánicos propiamente dichos. Aunque se evidencian pocas plantas (42,1%) y usos medicinales (5,8%) que son también compartidos entre la M.M.M. y los referidos en obras actuales, esto indicaría cierto grado de continuidad respecto a la farmacopea utilizada y a criterios etiológico-terapéuticos propios de la etnobotánica médica criolla del Paraguay.
Estudios funcionales de artefactos líticos de Cueva de las Manos, Río Pinturas, Santa Cruz, Argentina
Authors: Cattaneo G. Roxana , Aguerre Ana M.
Published: December 2020

El presente trabajo tiene como objetivo presentar los resultados del estudio funcional o de microhuellas de una muestra de raspadores procedentes de la excavación del sitio Cueva de las Manos. Fueron seleccionados entre los provenientes de las capas 4c, 5 y 6, que cuentan con fechados radiocarbónicos entre 1610 años AP a 9300 años AP. Por un lado nos interesó poder profundizar sobre qué materia prima trabajaron estos raspadores, ya que nunca había podido ser analizado en estudios anteriores. Por otro lado nos interesa ampliar el estudio de la variabilidad morfológica en relación a la variabilidad funcional en los raspadores ya que en este sitio es notable la variedad de instrumentos clasifi cados como raspadores y cepillos (rabots). Estos nuevos resultados permitirán además profundizar la discusión presentada en trabajos anteriores donde se infi rió una tendencia hacia una diferenciación entre ciertos subgrupos de instrumentos cuyos últimos usos conocidos fueron sobre un solo tipo de materia prima mientras que otros se asociaron con el trabajo de al menos dos tipos de materiales. Para este trabajo se utilizaron las observaciones realizadas con el Microscopio Láser Confocal de Barrido BioRad MRC600, luego analizadas a través de software de reconocimiento de imágenes “PHILOS”.
Osteometría de falanges proximales de camélidos sudamericanos modernos. Variabilidad, estándares métricos y su importancia como conjunto comparativo para la interpretación de restos hallados en contextos arqueológicos
Authors: Izeta Andrés D. , Otaola Clara , Gasco Alejandra
Published: December 2020

Las medidas obtenidas a partir de huesos del esqueleto apendicular de camélidos sudamericanos han sido utilizadas en los últimos años como insumo básico para interpretar distintos aspectos relacionados con su asignación especifica, manejo de rebaños y estrategias económicas, entre otros. La forma y el tamaño de los huesos han sido interpretados como el resultado de distintas fuerzas asociadas a distintos tipos de restricciones ambientales o modificaciones producto del manejo humano. Esto es de gran importancia a la hora de interpretar la historia de la relación humano-camélido, dado que el registro material obtenido en depósitos arqueológicos posee variados restos a través de los cuales se pueden reconstruir diversas situaciones ocurridas en el pasado, tanto a nivel de paleo-economías o paleoambientes. Gran parte de estas interpretaciones se han basado en escasas medidas de estándares moderno. Por ello, este trabajo tiene como objetivo presentar datos métricos obtenidos de individuos contemporáneos de camélidos sudamericanos y que han sido considerados relevantes para su uso como material comparativo. Con esto se intenta evaluar desde una mirada crítica el uso de estándares locales y no locales para la asignación específica de muestras arqueológicas. Con el fin de evaluar la variabilidad en la forma y el tamaño de las primeras falanges se aplica el Análisis de Componente Principal y de Conglomerados (UPGMA). Para ello se toman en cuenta diferencias de tamaño, forma y procedencia geográfica con el fin de observar el peso aportado por cada variable en la conformación de esta muestra. Como resultado se concluye que el uso de ambas técnicas más la procedencia geográfica de las muestras modernas permite una definición por especie de grano más fino.
Variación temporal y espacial en poblaciones prehispánicas de Córdoba. Análisis de ADN antiguo
Authors: Nores Rodrigo , Fabra Mariana , Demarchi Darío Alfredo
Published: December 2020

Se presentan nuevas evidencias sobre la evolución de las poblaciones prehispánicas del actual territorio de Córdoba a partir del análisis de ADN mitocondrial de restos humanos de procedencia arqueológica de distintos contextos culturales, geográficos y temporales. La muestra estudiada incluyó 53 individuos de los cuales 48 pudieron ser genotipificados para alguno de los cuatro haplogrupos mitocondriales fundadores americanos. La totalidad de los restos analizados (excepto uno) fueron previamente datados por AMS, presentando un rango de antigüedad de entre 4525 ± 20 y 345 ± 20 años AP. Los resultados obtenidos muestran diferencias genéticas significativas entre los grupos que habitaron las serranías y los que vivieron en la llanura extraserrana. Esta diferenciación, caracterizada por un fuerte incremento en la frecuencia del haplogrupo B en la zona serrana, habría surgido recién alrededor del 1200 AP, modificando sensiblemente el pool génico de la población antigua, que presenta un neto predominio del haplogrupo C. También se advierte para esa época un incremento en la frecuencia del haplogrupo A en la llanura, pero sin llegar a alterar substancialmente el perfil genético de la población antigua. Las altas prevalencias relativas en la llanura de los haplogrupos C y D, similares a la que presentan las poblaciones de Patagonia y Tierra del Fuego, coinciden, de manera sugestiva y ciertamente difícil de desentrañar, en la población contemporánea que habita la provincia de Córdoba, y sugieren un posible origen común con los habitantes del extremo sur del continente.
Identificación interespecífica de camélidos en el valle de Ambato (Catamarca, Argentina): una aproximación a la problemática desde distintas líneas de análisis
Authors: Dantas Mariana
Published: December 2020

Interspecific identification of camelids and distinction between llamas’ morphotypes in bone materials from archaeological sites are two major aspects in zooarchaeological studies of northwestern Argentina and the Andean region in general. This paper aims at contributing to the issue along different analytical approaches applied to camelids remains from Ambato Valley, Catamarca, between the 6th and 10th centuries AD. Thus, the integration of osteometric and stable isotope studies allowed establishing/confirming the presence of domestic camelids in this valley, based on their relative size and a selective diet mostly derived from C4 plants. It was also possible to distinguish two probably differently-sized groups of animals: one of larger animals or large llamas, and one of smaller size or small llamas, whose dimensions overlap with those of North Andean guanacos. A combination of both analyses allowed reaching a degree of differentiation not possible otherwise
Application of the BowTie Method in Accident Analysis: Case of Kaziwiziwi Coal Mine
Authors: Matsimbe Jabulani , Quarm Richmond Sam , Busharads Mohamed Osman Elamin
Published: December 2020

A BowTie is a diagram illustrating proactive and reactive risk management at any working environment. This case study applied the bowtie method to provide a simple visual analysis of the hazards that caused fatal accidents at Kaziwiziwi coal mine on 2nd November 2012 and 15th November 2019. Two coal miners were killed on the spot and others injured due to failure of a bucket hoisting system and hanging rock fall. The authors demonstrated that the bowtie method is an effective visualization tool that can be used to analyze the hazard, top event, threats, consequences, barriers and escalation factors of mining accidents; and therefore give an overview of everything not wanted around a certain hazard. Mining companies in Malawi will apply this new knowledge to proactively conduct situational audits of unwanted scenarios, and identify barriers to prevent accidents from happening so far as is reasonably practicable. In addition, the Department of Mines will find this bowtie visualization tool useful when carrying out accident analyses in the future which in turn will promote safety awareness and policy development in the mining industry, and suggest ways on how to keep the normal but hazardous aspects from turning into something unwanted.
Faculty Subjective Well-being: An Achievement Goal Approach
Authors: Rinas Raven , Dresel Markus , Daumiller Martin
Published: December 2020

Research indicates that faculty members struggle with compromised subjective well-being (SWB). Although motivation is considered central to SWB, little research has investigated this connection in faculty using comprehensive, multifaceted frameworks. To address this, the present study took an achievement goal approach to examining multifaceted SWB (positive and negative emotions, career and life satisfaction) in 1,335 faculty members from Germany, the USA, and India. Structural equation modelling revealed that, invariant across countries and institutions, achievement goals were meaningfully and differentially associated with SWB. Mastery (task) approach goals were particularly conducive to SWB, while work avoidance goals were detrimental. Moreover, mixed results emerged for performance and relational goals. These findings highlight the centrality of goals for understanding and supporting faculty development.
An Attempted Homicidal Cut Throat Injury: A Case Study
Authors: Sah Mukesh Kumar , Thakur Madhu
Published: December 2020

Homicidal cut throat is an injury over the front of neck by sharp instruments with an intent of murder. The neck contains vital structures (nerves, blood vessels, airway and pharyngeal conduit) in a compact fashion that may be difficult to access for physical examination or surgical exploration in a limited time. That is why these cases create panic and pose great challenges in the management. Here is a case of an attempted homicidal cut throat injury that highlights some of the challenges encountered in the management along with discussion on the evolving knowledge of the optimal management practice.
Effectiveness of Sexual Harassment Risk Reduction Education based on Health Belief Model: A Quasi Experimental Study
Authors: Thapaliya Radhika , Adhikari Samir Kumar
Published: December 2020

Background: Sexual harassment is a public health problem which has serious effects to girls’ psychosomatic health. Due to social stigma and lack of skills, even the girls can’t refuse sexual harassment. This study was done to evaluate the effectiveness of sexual harassment risk reduction education based on Health Belief Model.

Methods: A quasi experimental study was conducted in secondary level public schools of Tokha Municipality, Kathmandu. The study was done from 5th February 2016 to 5th May 2016. The sample size was 117 for each group which was calculated with input of 95% CI, power of test=80%, assuming 38 % change based on baseline study and 10% nonresponse rate. The ratio of participants in intervention and control group was 1:1 and the total numbers of participants were 128 in pretest and 121 in posttest at the intervention group and 131 in pretest and 122 in posttest in the control group. Data was collected by using self-administered questionnaire for knowledge and likert’s scale was used for attitude and behavioural intention. Lecture, group discussion, role play and brainstorming were methods used for intervention. After two weeks of intervention, a post-test was done.

Results: Testing of hypothesis revealed that the knowledge about sexual harassment, anti-sexual harassment attitude and behavioural intention of using refusal skills in sexual harassment in the intervention group were significantly higher than that of control groups i.e. p<0.001, p<0.001 and p<0.05 respectively.

Conclusion: Sexual harassment risk reduction education intervention based on health belief model is effective to increase the knowledge, attitude and behavioural intention of participants. The findings of the study encourage further exploring creative approaches to programming in other violence prevention areas.
Impact of specialized multidisciplinary care on cirrhosis outcomes and acute care utilization
Authors: Carbonneau Michelle , Davyduke Tracy , Congly Stephen E , Ma Mang M , Newnham Kim , Den Heyer Vanessa , Tandon Puneeta , Abraldes Juan G
Published: December 2020

Background: Multidisciplinary care has the potential to improve outcomes among patients with cirrhosis, yet its impact on this population remains unclear, with existing studies demonstrating discrepant results. Using data from the multidisciplinary outpatient Cirrhosis Care Clinic (CCC) at the University of Alberta Hospital, we aimed to evaluate acute care utilization and survival outcomes of patients followed by the CCC compared with those receiving standard care (SC). Methods: We performed a retrospective chart review of 212 patients with cirrhosis admitted to University of Alberta Hospital between 2014 and 2015. CCC patients ( n = 36) were followed through the CCC before index admission. SC patients ( n = 176) were managed outside of the CCC. Readmission time in hospital was collected until 1 year, death, or liver transplant. Results: CCC patients had more advanced liver disease (higher prevalence of ascites, encephalopathy, and varices). Despite this, acute care utilization was significantly lower among CCC patients (adjusted length of stay lower by 3 days, p = 0.03, and adjusted survival days spent in hospital lower by 9%, p = 0.02). CCC patients also had improved 1-year transplant-free survival, with an adjusted 1-year relative risk reduction of 53% ( p = 0.03). Total mean cost of care was lower in the CCC group by $2,280 per patient-month of life. Discussion: For patients admitted with cirrhosis, specialized post-discharge multidisciplinary outpatient care is associated with decreased acute care utilization, improved 1-year transplant-free survival probability, and the potential for cost savings to the system.
History of formation, taxonomic composition, biomorphological and ecological structure of the arboretum of Shatsk forest college named after V.V. Sulka
Authors: Dzyba А. А. , Rybchynska N. P. , Rybchynskyi А. А.
Published: December 2020

Arboretum of Shatsk Forest College named after V.V. Sulka, a valuable center of dendroflora for conservation and enrichment of biodiversity of Volyn Polissya, occupies an area of 1.5 hectares. The history of the formation of the arboretum of Shatsk Forest College named after V.V. Sulka from its creation to the present days (for 50 years) is given. The results of the arboretum dendroflora inventory are presented, with 147 species (109 rare species) belonging to 94 genera, 41 families, 23 orders, two classes. Most species belong to the Magnoliophyta division - 115 species (78.2%), whereas to Pinophyta division - 32 species (21.8%). Plants grow in the following plantings: groups, alleys, hedges, living walls, solitaires, and common mixed groups. 144 species of woody plants belong to phanerophytes, with mesophanerophytes (38.9%) (megaphanerophytes - 24.3%, microphanerophytes - 26.4%, nanophanerophytes - 10.4%) and 3 species of hamephytes predominating. An analysis of the ecological structure (in relation to: light demand, demand for moisture level, and demand for soil fertility) is given. The ecological structure is mostly represented by hemiskophytes - 65 species (44.2%) and heliophytes - 62 species (44.2%), while sciophytes - 20 species (13.6%) are significantly less represented. In relation to soil fertility demand, the following were identified: mesotrophs - 72 species (49.0% of the total number of species); slightly less oligotrophs (27.9%) and megatrophs (20.4%), and mesooligotrophs, which are the least represented - 2.7%. The range of woody plants species of arboretum consists of six types of hygromorphs, with mesophytes - 57 species and xeromesophytes - 25 species being the most common, whereas hygromesophytes - 4 species (2.7%) belong to less common. Almost by the same quantity hygrophytes (16 species, 10.9%), xerophytes (16 species, 10.9%), mesohygrophytes (18 species, 12.2%), and mesoxerophytes (11 species, 7.5%) are represented. The current state of woody plants was evaluated. 95% of woody plants are in good condition, with four species having satisfactory and four species - unsatisfactory condition.