bluuebunny/crossref_metadata_2025 huggingface dataset:
Feasibility of At-Home Serial Testing Using Over-the-Counter SARS-CoV-2 Tests With a Digital Smartphone App for Assistance: Longitudinal Cohort Study
Authors: Herbert Carly , Broach John , Heetderks William , Qashu Felicia , Gibson Laura , Pretz Caitlin , Woods Kelsey , Kheterpal Vik , Suvarna Thejas , Nowak Christopher , Lazar Peter , Ayturk Didem , Barton Bruce , Achenbach Chad , Murphy Robert , McManus David , Soni Apurv
Published: August 2022

Background

The ongoing SARS-CoV-2 pandemic necessitates the development of accurate, rapid, and affordable diagnostics to help curb disease transmission, morbidity, and mortality. Rapid antigen tests are important tools for scaling up testing for SARS-CoV-2; however, little is known about individuals’ use of rapid antigen tests at home and how to facilitate the user experience.

Objective

This study aimed to describe the feasibility and acceptability of serial self-testing with rapid antigen tests for SARS-CoV-2, including need for assistance and the reliability of self-interpretation.

Methods

A total of 206 adults in the United States with smartphones were enrolled in this single-arm feasibility study in February and March 2021. All participants were asked to self-test for COVID-19 at home using rapid antigen tests daily for 14 days and use a smartphone app for testing assistance and to report their results. The main outcomes were adherence to the testing schedule, the acceptability of testing and smartphone app experiences, and the reliability of participants versus study team’s interpretation of test results. Descriptive statistics were used to report the acceptability, adherence, overall rating, and experience of using the at-home test and MyDataHelps app. The usability, acceptability, adherence, and quality of at-home testing were analyzed across different sociodemographic, age, and educational attainment groups.

Results

Of the 206 enrolled participants, 189 (91.7%) and 159 (77.2%) completed testing and follow-up surveys, respectively. In total, 51.3% (97/189) of study participants were women, the average age was 40.7 years, 34.4% (65/189) were non-White, and 82% (155/189) had a bachelor’s degree or higher. Most (n=133/206, 64.6%) participants showed high testing adherence, meaning they completed over 75% of the assigned tests. Participants’ interpretations of test results demonstrated high agreement (2106/2130, 98.9%) with the study verified results, with a κ score of 0.29 (P<.001). Participants reported high satisfaction with self-testing and the smartphone app, with 98.7% (157/159) reporting that they would recommend the self-test and smartphone app to others. These results were consistent across age, race/ethnicity, and gender.

Conclusions

Participants’ high adherence to the recommended testing schedule, significant reliability between participants and study staff’s test interpretation, and the acceptability of the smartphone app and self-test indicate that self-tests for SARS-CoV-2 with a smartphone app for assistance and reporting is a highly feasible testing modality among a diverse population of adults in the United States.
Ketahanan Pangan Rumah Tangga Peternak Sapi Potong Rakyat di Daerah Istimewa Yogyakarta, Indonesia
Authors: Achmad Ferdian , Mulyo Jangkung Handoyo , Masyhuri Masyhuri , Subejo Subejo
Published: August 2022

ABSTRACT One of the determinants of the national resilience of a nation was food security. The food consumption sector had a very vital and strategic role in every country. This study aimed to knew and to compared the degree of food  security  between the households of beef cattle farmersunder the self-ownership  and the partnership systems in the Special Region of Yogyakarta province. The number of samples studied were as many as 240 beef cattle farmers, consisting of 120 self-ownership system farmers, and 120 partnership system farmers. The primary method of research using a quantitative approach that was descriptive analysis. An instrument of measuring used was cross-classification between the share of food expenditure (PPP) and energy sufficiency (AKE) which was measured using an indicator of Jonsson and Toole’s table (1991).The results showed that the household food security of beef cattle farmersself-ownership system was better than partnership system farmers. The level of food security of livestock households in DI Yogyakarta in aggregates were 17.92% food secure, 17.08% food vulnerable, 39.17% food less secure, and 25.83% food insecure. Based on the system of livestock ownership, households of self-ownership system farmers were 22.5% food secure, 15.83%   were food vulnerable, 40.00% food less secure, and 21.67% were food insecure. In partnership farmers, 13.33% food secure, 18.ABSTRAKSalah satu faktor penentu ketahanan nasional suatu bangsa adalah ketahanan pangan.Sektor konsumsi pangan memiliki peran yang sangat vital dan strategis pada setiap negara.Tujuan penelitian ini adalah untuk mengetahui dan membandingkan derajat ketahanan pangan rumah tangga peternak sapi potong antara sistem mandiri dan sistem gaduhan di DI Yogyakarta.Sampel yang diteliti  sebanyak 240 orang peternak sapi potong, terdiri dari 120 orang peternak sistem mandiri, dan 120 orang peternak sistem gaduhan. Metode dasar penelitian menggunakan pendekatan kuantitatif yang bersifat deskriptif analisis. Instrumen alat ukur yang digunakan yaitu klasifikasi silang antara pangsa pengeluaran pangan (PPP) dan angka kecukupan energi (AKE) yang diukur menggunakan indikator Tabel Jonsson dan Toole (1991).Hasil penelitian menunjukkan bahwa ketahanan pangan rumah tangga peternak sapi potong sistem mandiri lebih baik dibandingkan peternak sistem gaduhan. Derajat ketahanan pangan rumah tangga ternak di DI Yogyakarta secara agregat berturut-turut yaitu sebanyak 17,92% tahan pangan, 17,08% rentan pangan, 39,17% kurang pangan, dan 25,83% rawan pangan. Berdasarkan sistem kepemilikan ternak, rumah tangga peternak sistem mandiri sebanyak 22,5% tahan pangan, 15,83% rentan pangan, 40,00% kurang pangan, dan 21,67% termasuk rawan pangan. Pada peternak sistem gaduhan, sebanyak 13,33% termasuk rumah tangga tahan pangan, 18,33% rentan pangan, 38,34% kurang pangan, dan 30,00% rawan pangan..
Impact of Foreign Direct Investment on Nigeria’s Agricultural Sector (1981 to 2019)
Authors: Ogbanje Elaigwu Christopher , Salami Abubakar Onoja
Published: August 2022

The need to augment the financial policy interventions of the Central Bank of Nigeria in the agricultural sector is sine qua non. Since agriculture is still the mainstay of Nigeria’s economy, its reliance on foreign direct investment (FDI) ought to be ascertained. Consequently, this study investigated the impact of foreign direct investment on Nigeria’s agricultural sector. Time series data between 1981 and 2019 were obtained from the databases of the Central Bank and Food and Agriculture Organisation. The Augmented Dickey-Fuller test shows that the variables were I(1). Johansen’s co-integration test suggested long-run relationship among the variables. Findings revealed slower acceleration of agricultural productivity (6.28) than FDI (17.99). Also, FDI and exchange rate had statistically significant (p < 0.05) and negative impact on the agricultural productivity, while implicit price deflator for the agricultural sector had statistically significant (p < 0.001) and positive impact on agricultural productivity in the long-run. The error correction term indicates that the speed of adjustment to the short-run equilibrium was high (79.71%). Hence, reliance on foreign direct investment would have adverse effect on agricultural gross domestic product in the long-run. The Federal Ministry of Agriculture and Rural Development should evolve policies that would guarantee steady inflow of foreign direct investment to agriculture in a manner to reverse the negative impact or explore alternatives. In addition, the Central Bank of Nigeria should adopt a sound monetary policy to attain stability in the exchange rate as well as supply of FOREX to ease purchase of agricultural inputs.
Multiculturalismo mágico en una ciudad de Chiapas
Authors: Cañas Cuevas Sandra
Published: August 2022

El libro es una crítica a los proyectos de ciudadanía y nación vigentes. Desde una mirada etnográfica, muestra cómo funcionan los artificios del multiculturalismo en el diario acontecer de una ciudad turística, habitada en su mayoría por población indígena. En este libro, la autora rescata las historias de mujeres y hombres indígenas de orígenes diversos que, desde hace ya varias décadas, han habitado la periferia urbana de esta ciudad.
Isoeugenol Ester Derivatives as Future Potential Drug
Authors: Gangan Vijay D.
Published: August 2022

Abstract: Isoeugenol has wide medical applications. It is used in manufacturing perfumeries, flavorings, essential oils (odour description: Clove, spicy, sweet, woody) and in medicine (local antiseptic and analgesic). Its analogues also show various biological activities which prompted us to synthesize few more analogues for their future applications as bioactive molecules. These were synthesized by coupling isoeugenol with benzoyl chloride / substituted benzoyl chloride / acetyl chloride using pyridine as a base in dichloromethane as a solvent at 150C to RT for 8hrs. These synthesized analogues were unambiguously characterized by 1H NMR, elemental analysis and Mass spectral data. Few of them showing promising antibacterial activity.
Modern IoT Based Gardening System
Authors: Shariff Shafiulla , H S Saraswathi , G R Meghana , K Usha , K N Archana
Published: August 2022

Abstract: This paper aims at developing an auto irrigation/gardening system with raspberry pi. This system is easy to manage as allusers are able to login by Smartphone and access the condition of garden. These features sense that, user can access the parameters of the land such as moisture, temperature etc. and also water flow can be controlled, as well as supplies the water when required. To implement this system soil moisture, temperature, humidity and sunlight are fed into microcontroller. Web server running on raspberry pi receives this data and can transit to the mobile phones or any other device, which requests the data. Based on the obtained data, end-user can then control the system remotely. The special feature of the model is that, the user will ensure if his/her need of the plants, herbs are served based on the right need and there is over/under usage of the water. A Web server along with a web page will help in user being notified about the requirements of the water when required.
Analysis on Methods for Detecting Brain Tumor from MRI images
Authors: Kumar Dr. S. P. Predeep , Peter Dr. K. John , Kingsly Dr. C. Sahaya
Published: August 2022

Abstract: Brain tumor detection from MRI images is a challenging process due to high diversity in the tumor pixels of different peoples. Automatic detection has got wide spread acclaim because the manual detection by experts is time consuming and prone to error in judjement.Due to its high mortality rate, detection of tumor automatically is a new emerging technique in bio medical imaging. Here we present a review of few methods from simple threholding to advanced deep learning methods for segmentation of tumor from MRI data. The segmentation of tumor methods is classified to image segmentation using gray level processing, machine learning and deep learning. We compare the result of various method in an attempt to find the best methods available. As medical imaging methods have improving day by day we hope this review will help to understand emerging trends in brain tumor detection.
Prospects of Electric Vehicles in India
Authors: S Dr. Varalakshmi , Bajpai Prof. Anila , Reddy Prof. Krishna , K Dr. Lakshman
Published: August 2022

Abstract: The global automobile industry is seeing a major shift towards e-mobility over the past decade. There is a rapid increase in concept cars being turned into production cars over the years. Following the suit, India also has big plans for the emerging Electric Vehicles and its technologies in the country. In this study it is aimed to highlight, counter and suggest some solutions to the challenges that lie ahead.
Design A Mini Operating System Using Open Source System
Authors: Katiyar Dr. Ravindra Nath , Yadav Sadhna
Published: August 2022

Abstract: COSMOS (C# Open Source Managed Operating System) Paper provides a framework and tool-chain to develop an OS purely in managed code (C# and VB .NET). Cosmos supports integration with Visual Studio, and therefore is much easier to use. However, the framework is not rich, and therefore, there is still a lot of work to be done on OS developer side (E.g., it does not support mouse, file system etc.) In this paper, a microkernel based OS is developed using COSMOS framework for x86 based computer systems. This paper demonstrates device driver (PS/2) pointing device and GUI System. Since Cosmos does not provide support file system, mouse, keyboard, we have designed appropriate drivers for screen, mouse and keyboard. We have developed Event handlers and drivers for each device.In this part, we have developed drivers for Hard Disk and RAM to detect them in order to achieve partial fulfilment. From the development of general purpose computers, software industry has also evolved. However, there is not much improvement in OS development, as compared with other fields of software world: while other fields are enjoying power of garbage collection, OS developers are still doing their job in classic languages like C, C++ and assembly. Although there has been some research work regarding this, none of them was successful. This project is an attempt to develop a mini OS in pure managed code, particularly C# and .NET Framework 4.0.
Superoxide Dismutase (SOD): A Promising Enzyme in the Area of Biopharmaceuticals in Its Native and Immobilized Form: A Review
Authors: A Dr Swaroopa Rani , M Dr Lourdu Maria Das
Published: August 2022

Abstract: Super Oxide Dismutase (SOD) an ubiquitous potent antioxidant enzyme primarily scavenges reactive oxygen species (ROS) like superoxide radicals, which causes oxidative damage to a living organism’s essential proteins, lipids and its DNA. The accumulation of ROS in the body is a major inductive factor aging related diseases. It is important to maintain ROS at an appropriate level to prevent these diseases. SOD is a vital enzyme in defending against oxidative damage in vivo. The SOD enzyme promises to be a good therapeutic agent against ROS. The present review describes the therapeutic effects of SOD in some physiological and pathological conditions. Because of the defects in the direct application of SOD or SOD mimics, different mounting delivery systems (immobilization enzyme systems) have been developed for the efficient applications of SOD to realize antioxidant treatment.
OWN PROPERTIES AND SELF-ORGANIZATION NATURAL SYSTEMS
Authors: Balakshin O. B
Published: August 2022

The problem of self-organization of natural systems of Nature and its connection with the self-development of living systems is investigated. In the history of science there is no law devoted to this fundamental problem. However, the grandiose purposeful achievements of Nature testify that it exists. The peculiarity of this work is that it includes a chain of known facts, the unknown interconnection of the links of which, according to the author, follows the problem of self-organization of natural systems. The prevailing one-dimensional tendency for a long time to explain all problems solely on materialistic grounds turned out to be not always objective and therefore ineffective. The restoration of the multidimensional role of metaphysics, established by the monograph by Yu.S. Vladimirov, removed many restrictions. This allowed us to explore and connect the limiting cases, limiting ourselves to a sequence of well-known information-logical generalizations: Hegel’s dialectic, I. Kant’s a priori knowledge, M.A. Marutaeva, Leonardo da Vinci’s phenomenon of the golden section, L. Euler’s eigenvalues and D.I. Mendeleev.
PHILOSOPHICAL INTERPRETATION OF THE CONCEPTS OF QUANTUM MECHANICS “STATE” AND “TIME” IN THE TREATISE OF W. HEISENBERG'S “REALITY AND ITS ORDER”
Authors: Rybakova Irina A.
Published: August 2022

W. Heisenberg's treatise “Reality and its order” is a philosophical work of a scientist and philosopher and reflects the totality of his views on various aspects of reality. In this article, the author attempts to analyze the central concepts of quantum mechanics, “state” and “time”, as well as to determine how relevant the ideas of the treatise may be in the world of modern natural science. This point seems especially important, given the time of writing the treatise (no later than 1942), which gives reason to recall the philosophical foundations on which physics rests, and give them a new interpretation that meets modern challenges. The article shows the need to build modern physics on the principles of metaphysics, that is, to study the subject of physics from the position that the world has a metaphysical basis. Statements about the nature of time by various authors are given: from ancient natural philosophers (Aristotle) to medieval thinkers (Augustine, Grossetest), as well as modern researchers (A.Yu. Sevalnikov, Yu.S. Vladimirov, V.D. Zakharov), etc.
STRONGLY VIOLATED SCALE INVARIANCE OF SPACE-TIME (QUANTUM-MECHANICAL ASPECT)
Authors: Frolov B. N
Published: August 2022

The hypothesis that the Universe in its evolution exhibits, to one degree or another, strongly violated scale invarianceis discussed. The fundamental group of space-time now is not the Poincaré group, but the Poincaré-Weyl group. In case with a very high probability a particle is found near its classical trajectory, but there is an extremely small (but nonetheless nonzero!) probability of detecting this particle far from its classical trajectory, providing quantum mechanical nonlocality both in space and in time. The considerations presented here, in their further study, may lead to the formulation of a new interpretation of quantum mechanics. А possible change in Planck’s constant over time is discussed.
Resilience in the food sector – environmental, social and economic perspectives in crisis situations
Authors: Franc-Dąbrowska Justyna , Drejerska Nina
Published: August 2022

Environmental, social and economic perspectives, derived from the sustainability approach and present within by the resilience concept, are integral parts of food systems. At the same time they are clearly articulated within the EU farm-to-fork (F2F) strategy referring to building up resilience to possible future crises as diseases and pandemics. The aim of this paper is to investigate resilience in the food sector referring to its selected environmental, social and economic dimensions, which in fact rely on each other and cannot be separated, simply because of the character of food system itself (work with living organisms, soil, within natural environment, etc. done by people for business purposes). The issue of resilience in the food sector must be considered multidimensionally. In this approach, the basic direction of activities should be the one focused on the resilience approach, both in environmental protection and society. For a harmonious combination of these activities, it is also necessary to look at economic perspective of food system and entire rural livelihoods (e.g. income and employment diversification). Considering the last shocks discussed (COVID-19, war in Ukraine, drought, embargo on grain exports from Russia, rising inflation), a difficult situation on the food market can be expected in the nearest future, which makes the concept of resilience in the food sector even more relevant than it has been so far.
2021 Consensus Statements on the Cytoreductive Nephrectomy for Metastatic Renal Cell Carcinoma From the Korean Renal Cancer Study Group (KRoCS)
Authors: Lee Chan Ho , Kang Minyong , Kwak Cheol , Kim Sung Han , Kim Jung Kwon , Park Jae Young , Seo Seong Il , Seo Ill Young , Suh Jungyo , Song Wan , Song Cheryn , Yuk Hyeong Dong , Lee Sangchul , Lee Hyung Ho , Chung Jinsoo , Jeong Chang Wook , Jo Jung Ki , Choi Chang Il , Choo Seol Ho , Han Jun Hyun , Hwang Eu Chang , Kim Miso , Kim Chan , Choi Seock Hwan , Hong Sung-Hoo
Published: August 2022

Purpose: The Korean Renal Cancer Study Group (KRoCS) provides consensus recommendations on the role of cytoreductive nephrectomy (CRN) in patients with metastatic renal cell carcinoma (mRCC).Materials and Methods: A group of mRCC experts from the Korean Urological Oncology Society convened at the 2021 KRoCS meeting on CRN for mRCC.Results: The consensus document was developed to address 4 questions related that were judged to be the most relevant to patient care: (1) Is there a role for CRN in patients planning targeted therapy? (2) Is there a role for CRN in patients planning immuno-oncology agents? (3) When is the optimal time of CRN in patients planning systemic treatment? (4) What is the ideal patient selection for CRN? The panelists have come up with following consensus. For mRCC patients, CRN should be considered only in those with IMDC (International Metastatic Renal Cell Carcinoma Database Consortium) favorable and intermediate risk disease, regardless of the systemic treatment plans. Timing of CRN should consider the risk group as well as the number of risk factors, but is generally recommended for after assessing the degree of response to initial systemic treatment. Patients with good performance status, limited metastatic burden on top of resectable primary tumor are candidates recommended for CRN with or without metastasectomy with priority.Conclusions: In conclusion, there is still a role for CRN in the multimodality treatment of mRCC. Careful patient selection is of paramount importance. As the treatment landscape of mRCC continues to change, the role of CRN in the current immuno-oncology era will require more exploration.
CEO social capital and the value relevance of accounting metrics: International evidence
Authors: McCumber William R. , Qiu Huan , Islam Md. Shariful
Published: August 2022

Using a unique dataset of CEO social capital between 1998 and 2017, we investigate the degree to which CEO social capital increases or decreases investors’ reliance upon traditional accounting metrics when valuing the equity of non-US firms. We find, ceteris paribus, that investors rely more heavily on the book value of equity, rather than on earnings per share, to value common stock when the firm is led by a CEO with greater social capital. These findings suggest that CEO social capital erodes investors’ confidence in the quality and relevance of earnings; CEOs with higher social capital are entrenched and may engage in rent-seeking behaviors. These findings are robust to country-level development, efficiency, corruption comparisons, and alternative model specifications.
ANALISIS TINDAK TUTUR ILOKUSI DALAM FILM ADA CINTA DI SMA SUTRADARA PATRICK EFFENDY
Authors: Ningsih Lisa Widya , Muristyani Septi
Published: August 2022

Tujuan dari penelitian ini adalah untuk mendeskripsikan jenis dan fungsi tindak tutur ilokusi dalam dialog film Ada Cinta di SMA sutradara Patrick Effendy. Penelitian ini merupakan penelitian deskriptif kualitatif. Sumber data penelitian ini adalah dialog film Ada Cinta di SMA sutradara Patrick Effendy. Data penelitiannya adalah data lisan yang mengandung tindak tutur ilokusi yang meliputi bentuk tindak tutur representatif, tindak tutur direktif, tindak tutur komisif, tindak tutur ekspresif, dan tindak tutur deklaratif. Data diperoleh dengan metode simak, yang dilanjutkan dengan teknik rekam, transkip, dan catat. Hasil penelitian dari tindak tutur representatif yang ditemukan berfungsi menyarankan, meginformasikan, dan memberitahukan. Tindak tutur direktif yang ditemukan berfungsi memerintah, meminta, mengajak, dan menasihati. Tindak tutur komisif yang ditemukan berfungsi berjanji, memanjatkan doa, dan menolak. Tindak tutur ekspresif yang ditemukan berfungsi mengejek, memperingatkan, meminta maaf, dan mengucapkan selamat . Tindak tutur deklaratif yang ditemukan berfungsi melarang.
Pendampingan Regulasi Kemasan Pangan Secara Daring bagi UMKM di Desa Wisata Provinsi Bali
Authors: Seftiono Hermawan , Wong Abraham , Gunawan Irfan Indra
Published: August 2022

Kemasan produk pangan di pasaran masih banyak yang tidak mencantumkan informasi sesuai dengan regulasi kemasan pangan dari BPOM. Oleh karena itu, diperlukan edukasi bagi para UMKM. Pengabdian terkait regulasi pangan berperan agar UMKM dapat memberikan informasi terkait produk pangan kepada konsumen. Pelatihan dapat dilakukan secara daring menggunakan platform zoom meeting. Penyampaian materi dilakukan satu arah melalui ceramah dan tanya jawab. Setelah pengabdian ini para UMKM akan mencantumkan informasi sesuai standar Peraturan Badan Pengawas Obat dan Makanan No. 31 tahun 2018.
Model Manajemen Masjid Transformatif bagi Masyarakat di Masa Pandemi Covid-19
Authors: Rohimat Asep Maulana , Putra Rosyid Nur Anggara , Kholis Nur , Istanto Istanto
Published: August 2022

Pandemi Covid-19 berefek besar terhadap dinamika masyarakat. Fenomena ini menjadikan tantangan bagi para Pengelola Dewan Kemakmuran Masjid (DKM) untuk ikut berperan aktif dalam penanganan problem yang kompleks akibat pandemi. Pengabdian ini bertujuan untuk mengungkap secara mendalam konsep dan model manajemen Masjid Ostium Regency Kartasura sebagai masjid transformatif pada masa pandemi Covid-19. Menggunakan model obervasi partisipan, bahwa para penulis adalah dosen yang melakukan pengabdian masyarakat sebagai  pengurus DKM yang telah merumuskan dan melakukan model manajemen masjid transformatif yaitu menjadi agen perubahan di tengah masyarakat. Model pertama, pemberlakukan praktik shalat berjama’ah sesuai protokol kesehatan tanpa mengurangi syarat dan rukun shalat. Kedua, praktik socio-entrepreneurship masjid untuk pemberdayaan ekonomi masyarakat terdampak. Ketiga, alokasi bantuan dana dari infak masjid untuk membantu warga yang melakukan isolasi mandiri akibat terpapar Covid-19. Keempat, masjid menjadi garda terdepan sosialisasi protokol kesehatan pencegahan Covid-19. Kelima, masjid membuat model pendidikan transformatif di masa pandemi. Keenam, model kolaborasi dengan PKK ibu-ibu dan pengurus RT.
Pelatihan Produksi Podcast bagi Siswa Madrasah
Authors: Zulhazmi Abraham Zakky , Azizah Nurkhasanah  , Ramadhan Ekagandhi Destariyadi  , Arif Wiyono
Published: August 2022

Dinamika komunikasi digital berkembang pesat, salah satunya ditandai dengan populernya podcast beberapa tahun terkahir. Podcast tergolong sederhana, ia bisa berupa monolog ataupun dialog. Podcast juga tidak harus dalam bentuk audio visual, ia dapat berupa audio yang diunggah di Anchor, Spotify atau platform-platform lain. Produksi podcast hari ini relatif murah dan mudah. Didasari hal tersebut, program studi Komunikasi dan Penyiaran Islam UIN Raden Mas Said Surakarta menginisasi pengabdian masyarakat terkait produksi podcast yang berkolaborasi dengan mahasiswa pegiat Radeka FM. Tujuan pengabdian ini adalah untuk memberikan pelatihan produksi podcast bagi siswa madrasah, dalam hal ini siswa MAPK MAN 1 Surakarta.  Hasil pengabdian masyarakat ini adalah siswa MAPK MAN 1 Surakarta diberikan pelatihan dengan materi teori-teori dasar podcast. Selanjutnya, di hari kedua, siswa melakukan praktik langsung dipandu pegiat Radeka FM dengan materi pengoperasian alat, kiat menjadi host dan materi tambahan berupa pelatihan voice over. MAPK MAN 1 Surakarta memiliki keunggulan karena telah memiliki studio podcast dengan alat-alat yang memadai. Hal yang perlu ditingkatkan adalah pengembangan SDM/pengelola, agar kualitas podcast yang dihasilkan semakin optimal.
High-quality haplotype-resolved genome assemblies of ring-cup oak (Quercus glauca) provide insight into the demographic dynamics of a dominant tree in East Asia subtropics evergreen broadleaved forests
Authors: LUO Chang-Sha , Li Tian-Tian , Song Ying , Fan Ting-Ting , Shen Xiang-Bao , Yi Rong , Ao Xiao-Ping , XU Gang-Biao , JIANG Xiao-Long , DENG Min
Published: August 2022

Quercus section Cyclobalanopsis is a dominant woody lineage in East
Asian evergreen broadleaved forests. Regardless of its significant
ecological and economic importance, little was known on the genome of
this unique oak group. Quercus glauca, also known as ring-cup oak, is
the most widespread tree in section Cyclobalanopsis. In this study, a
high-quality haplotype-resolved reference genome of Q. glauca was
generated from PacBio CCS and Hi-C reads. The genome size, contig N50,
and scaffold N50 of Q. glauca are 902.8 Mb, 7.6 Mb, and 69.3 Mb,
respectively, for haplotype1, and 913.2 Mb, 7.2 Mb, and 71.5 Mb,
respectively, for haplotype2. The LTR Assembly Index of the Q. glauca
genome was more than 22. A total of 37,460 and 38,312 protein-coding
genes were predicted in haplotype1 and haplotype2, respectively.
Homologous chromosomes of Q. glauca had excellent gene pair
collinearity. A total of 905 R-genes were detected in Q. glauca. The
divergence between Q. glauca and Q. suber occurred about 44.6 million
years ago, agreeable to the earliest fossil records of section
Cyclobalanopsis found in East Asia. The global climate change before the
late Miocene and local climate change since the Pliocene were the main
causes of the effective population size change of Q. glauca. The
high-quality genome assembly of the most widespread species of section
Cyclobalanopsis can provide essential genomic resources for unraveling
the evolution mystery of the main oak lineages, and to promote the
application of genomic data on the interspecific introgression, local
adaptation, and speciation studies of oaks.
Vaginal Lactobacillus iners abundance predicts outcome in antibiotic treatment of bacterial vaginosis
Authors: Zhou Rui , Lu Jingjing , Wang Jun , Xiao BingBing
Published: August 2022

OBJECTIVES: To examine the distribution of Gardnerella genomospecies in
a Chinese cohort, investigate its relationship with BV and elucidate the
potential function of L. iners in predicting the clinical outcome of BV.
POPULATION: 130 non-pregnant BV patients and 41 healthy women from
Peking University First Hospital. MAIN OUTCOME MEASURES: Patients
visited clinic again after antibiotic treatment and divided into three
groups according to Nugent score. METHODS: Vaginal swabs used for
microscopic examination, 16SrRNA sequencing, bacterial culture and
isolation and Gardnerella vaginalis, Atopobium vaginae and Lactobacillus
iners isolates used for competition tests. RESULTS: Seven Gardnerella
genomospecies were presented in all participants and relative abundance
of all detected genomospecies were higher in BV patients
(p<0.05). Cured patients possessed higher GS03 compared to
other groups (p=0.005, 0.0337). L. iners was significantly higher in
cured patients compared to other groups (p=0.0021, p<0.0001)
and it was able to inhibit the growth of Gardnerella vaginalis and
Atopobium vaginae. CONCLUSION: Seven Gardnerella genomospecies can be
detected in Chinese BV patients, but its distribution is not related to
BV. Cured patients possess higher relative abundance of L. iners is
higher and L. iners can inhibit growth Gardnerella vaginalis and
Atopobium vaginae. L. iners might become a predictive indicator of
clinical outcomes of BV patients and its antimicrobial function might be
beneficial to BV patients. FUNDING: National Key Research and
Development Program of China (2021YFC2301000) and the National Natural
Science Foundation of China (81971342). Key words: bacterial vaginosis,
Gardnerella genomospecies, Lactobacillus iners, 16SrRNA sequencing,
antimicrobial activity.
The role of the blood-brain barrier in psychiatric disorders
Authors: Lackovic Maja , Ivkovic Maja , Vicentic Sreten , Jerotic Stefan , Nestorovic Milica , Stojkovic Tihomir , Pavlovic Aleksandra
Published: August 2022

The blood-brain barrier (BBB) is formed by continuous, closely connected
endothelial cells, enveloped in the basal lamina, pericytes, and foot
extensions of astrocytes. BBB has a vital role in brain metabolism and
protects the brain parenchyma from harmful agents present in the systemic
circulation. Damage to the BBB and an increase in its permeability have an
important role in many neurodegenerative diseases. This paper aims to
review the literature on the impact of the BBB damage on psychiatric
illness, a largely neglected and under researched area. Links between BBB
impairment and specific neuropsychiatric disorders are described including
schizophrenia, affective disorders, dementias with behavioral disorders, and
alcohol use disorder, with comparison to typical hereditary small vessel
diseases affecting the BBB such as cerebral autosomal dominant arteriopathy
with subcortical infarction and leukoencephalopathy (CADASIL) and
mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes
(MELAS). The authors critically summarize possible pathogenic mechanisms
linking BBB damage and these common disorders.
COVID-19 testing, infection rates, and related outcomes in adults with intellectual and developmental disabilities (IDD): An application of linked administrative health data to support Ontario’s COVID-19 response.
Authors: Troke Natalie , An Diana , Kim Eliane , Balogh Robert , Plumptre Lesley
Published: August 2022

ObjectivesPeople with intellectual and developmental disabilities (IDD) have been disproportionately impacted by COVID-19, a population more likely to experience poor health outcomes. An Applied Health Research Question (AHRQ) request through ICES led to an investigation that monitored COVID-19 related infections and outcomes in adults with and without IDD.

ApproachThe ICES-AHRQ team approved a request from the Ministry of Children, Community and Social Services (MCCSS), to determine the proportion of adults with IDD tested and confirmed positive for COVID-19. The scientists also explored if positive IDD cases experienced similar health outcomes to the general population. The open cohort was derived by linking those with a COVID-19 test in Ontario Laboratories Information System, from January 2020 to December 2021, to supplemented positive case data and administrative health databases. An algorithm was used to define IDD by a series of inpatient hospitalizations, emergency department and/or physician visits, with IDD diagnostic codes.

ResultsSimilar rates of testing and positivity were observed for those with (46%; 6%) and without IDD (43%; 5%). However, adults with IDD confirmed positive for COVID-19 were mostly male (62% vs 49%), aged 18-29 (40% vs 27%), had medical conditions associated with frailty (15% vs 4%), and from the lowest neighborhood income quintile (27% vs 23%), compared to the non-IDD population, respectively. Cumulatively, deaths and hospitalizations following a COVID-19 diagnosis were two-times more likely in the IDD population, while comparable rates of intensive care unit (ICU) admissions were reported. Particularly, adults with IDD aged 18-54 experienced higher rates of hospitalizations (48% vs 30%), ICU admissions (56% vs 36%), and deaths (26% vs 6%), compared to the same age group in those without IDD.

Conclusion/ImplicationsReal-time administrative health data and analytics were used to support Ontario’s COVID-19 response in those with IDD. To inform decision making and policy actions related to immediate testing strategies, MCCSS used such findings to increase the availability of testing for adults with IDD, who may face multiple barriers.
The Canadian Neighbourhood Early Childhood Development (CanNECD) Socioeconomic Index: Stability and Measurement Invariance Over Time.
Authors: Forer Barry , Pottruff Molly , Duku Eric , Guhn Martin , Janus Magdalena
Published: August 2022

Objectives and ApproachThe CanNECD SES Index is a composite of 10 Canadian Census and Income Tax Filer variables, aggregated to 2,038 custom neighbourhoods covering all of Canada. The baseline 2006 Index accounted for 32% of the neighbourhood-level variance in overall developmental vulnerability in Kindergarten children, as measured by the Early Development Instrument (EDI). Other existing SES indices accounted for 17% at most.

The Index now has two additional time points (2011 and 2016), which allows an evaluation of its consistency over time. Our objective is to assess three aspects of the Index’s temporal consistency. The first is the consistency of the strength of association between the Index and vulnerability rates across EDI developmental domains. The second is the consistency of neighbourhoods’ quintile rank over time. Finally, we use Confirmatory Factor Analysis in an SEM framework to assess the Index’s measurement invariance over time.

ResultsFor each EDI domain, the strength of association between Index scores and neighbourhood-level vulnerability rates were either maintained or minimally declined over time. Additionally, neighbourhood quintile rankings were highly consistent over time with over 60% of neighbourhoods in the same quintile between 2006 and 2016, and fewer than 3% with a greater than one-quintile change. Finally, our preliminary measurement invariance results show at least configural invariance over the three time points.

Conclusion / implicationsOur results confirm the stability of the CanNECD Index, justifying its utility for: mapping SES indicators across neighbourhoods and over time, contextualizing neighbourhood-level developmental vulnerability in young children, and identifying interesting neighbourhoods for future study, especially those where the children are faring much better than predicted by the Index.
Linkage of national clinical datasets without patient identifiers using probabilistic methods.
Authors: Blake Helen , Sharples Linda , Harron Katie , Van der Meulen Jan , Walker Kate
Published: August 2022

ObjectivesTo develop a step-by-step process for probabilistic linkage of national clinical and administrative datasets without personal information, providing guidance on selecting variables for linkage, estimating match weights, and choosing the probabilistic linkage threshold. To validate this process against deterministic linkage using patient identifiers.

ApproachWe undertook probabilistic linkage without personal information using electronic health records from the National Bowel Cancer Audit (NBOCA) and Hospital Episode Statistics (HES) databases for bowel cancer patients undergoing emergency surgery in England. We selected linkage variables based on completeness, and ability to discriminate between matches and non-matches, assessed using a novel score derived from m-probabilities and u-probabilities. Taking deterministic linkage using patient identifiers as the reference-standard, we calculated sensitivity and specificity of probabilistic linkage, plotted a Receiver Operating Characteristic curve across alternative thresholds of match weights, and compared patient characteristics and estimates from fitted regression models between linkage methods.

ResultsWhen considering the ability to discriminate between matches and non-matches, patient and administrative variables tended to discriminate better than clinical variables. 81.4% of NBOCA records were linked to HES using probabilistic linkage, versus 82.8% using deterministic linkage. Most NBOCA records were linked to HES using both methods (8,427/10,566). Probabilistic linkage had over 96% sensitivity and 90% specificity compared to deterministic linkage using patient identifiers.  Patients that linked deterministically, but not probabilistically, were younger and more likely to have emergency admission, but otherwise had similar characteristics. Regression models for mortality and length of hospital stay according to patient and tumour characteristics were not sensitive to the linkage approach.

ConclusionProbabilistic linkage without personal information can be used as an alternative to deterministic linkage using patient identifiers, or as a method for enhancing deterministic linkage. It allows analysts outside highly secure data environments to undertake linkage while minimising costs and delays, protecting data security, and maintaining linkage quality.
Linking Eight Decades of Canadian Census Collections.
Authors: Foxcroft Jeremy , Inwood Kris , Antonie Luiza
Published: August 2022

IntroductionLinking the many decades of census data collected during Canada’s settlement allows researchers to investigate the movement patterns of early settlers, changes in regional demographics, and intergenerational mobility. This research leverages new methodologies and previously untranscribed individual attributes to link for the first time Canadian censuses from 1852 to 1921.

Objectives and ApproachThis work aims to build upon prior efforts (1871-1901 linking) to link the decennial Canadian censuses spanning from 1852 to 1921. We use a more complete transcription of the censuses, that has recently become available to researchers through The Canadian People’s project.

Our approach to this task begins with reproducing the results of previous work using data from this new transcription. From there, we add additional time-invariant individual characteristics as features to our classification model. We also explore newer methodologies designed to leverage household information during the linkage process, with the goal of increasing the linkage rate.

ResultsWe describe the differences between the different methodologies we use, and the steps we took to clean and standardize the data. We compare the links produced by the different methodologies in terms of the number of links yielded, their quality (false positive rate), and certain aspects of the bias present in the resulting collections of links. We discuss the challenges and potential approaches to dealing with sections of the population who remain difficult to link.

We expect the advancements in record linkage methodologies for historical populations coupled with this more complete transcription of the censuses to offer advantages over prior approaches when linking these censuses. We expect the resulting linked data to offer new insight into Canada during this time period.

Conclusions/ImplicationsThe resulting collection of linked data over this time period should characterize approximately three generations of early Canadians. This linked data will be passed on to other researchers and will allow us to better understand the changing experiences of the Canadian population during these early stages of Canada’s development.
Preliminary comparison of gun homicide deaths for non-probation and probation clients.
Authors: Doshi Kruti , Hinami Keiki , Boulger Jordan , Zhang Huiyuan , Trick William , Rasmussen Luke
Published: August 2022

ObjectiveTo measure a baseline rate of gun homicide deaths for adults on probation in Cook County, Illinois, USA.  To compare this rate to the rates for the population of the City of Chicago and for all of Cook County, which includes Chicago and suburban Cook County.
ApproachIn March of 2022, two data contributing partners, Cook County Adult Probation Department (APD) and Cook County Medical Examiner’s Office (CCME), partnered with Cook County Health for salt and crypto generation and the Medical Research Analytics and Informatics Alliance (MRAIA) as the data generator.  We used the open source Linkja program (https://linkja.github.io/) to match adult probation records with gun homicide death records from CCME.  For our study period, CY 2018 through 2021, APD submitted a hashed roster of 53,969 unique individuals active on probation, which was matched to 307 records of gun homicide deaths.
ResultsOverall, there were 3,728 gun homicides in the CCME data, 8% (n=307) involved individuals on probation.  The average age was 34 years at death, almost 91% were male (n=3,374), 71% Black (n=2,650), and 14% Hispanic (n=536).  Among individuals who died from gun violence, compared to those not in the probation data, probation clients tended to be younger (29 vs 33, p<.001) and more likely to be Black (89% vs. 69.5%; p<.001),
We found that the rate of gun homicide deaths per 100,000 probation clients was 569, ~22 times higher than the rate for the City of Chicago in 2020 (rate=25 per 100,000) and ~33 times higher than the rate for Cook County in 2020 (rate=17 per 100,000).
ConclusionPrivacy-preserving record linkage software enabled a cross-departmental data sharing project that heretofore was not realized due to privacy concerns and existing data use agreements.  Our results highlight an excessive risk of homicide among adult probation clients, particularly among young black males.
Engagement of persons with lived experience in research that uses linked administrative health data - the BC Provincial Overdose Cohort.
Authors: Slaunwhite Amanda , Palis Heather , Xavier Chloe , Desai Roshni , Zhao Bin , Zhao Bin
Published: August 2022

Illicit drug overdose is a significant public health challenge in British Columbia (BC) that has been worsened by the COVID-19 pandemic. In 2021, 2224 persons died of overdose in BC– more than any year on record. The vast majority of overdose deaths are attributed to consumption of illicit substances and poisoning due to fentanyl.  Since the 2016 emergency declaration, efforts have been made to create new data infrastructure that allows for comprehensive ascertainment of non-fatal and fatal overdose. The BC Provincial Overdose Cohort (BC-ODC) is a unique cohort that was created under public health order that includes all identified cases of illicit drug overdose in BC from January 1 2015-December 31, 2020 that is updated annually. With its unique data extracts, shared data governance structure and novel mandate, a critical component of stewarding the BC-ODC is engagement of persons with lived experience of substance use, overdose and/or incarceration. Two initiatives were launched in 2019 and 2022 to work with persons with lived experience to prioritize research that uses the BC-ODC data. Engagement of persons with lived experience of incarceration started in 2022 to inform projects that examined topics related to decriminalization, criminal legal system involvement (charges and convictions) and incarceration. This presentation will describe these initiatives to show the importance of peer involvement in research that uses linked administrative health data particularly when designing, interpreting and disseminating findings to reduce stigma towards persons who use substances.