bluuebunny/crossref_metadata_2025 huggingface dataset:
COVID-19 Severity and ABO Blood Types; Association and Molecular Mechanisms A short Review
Authors: Khan Nazia Hasan , Mannan Nusrat , Zaman Mohammad Saroare , Akram Arifa
Published: January 2022

Genetically inherited characteristics of blood group phenotypes, whose association with certain infectious diseases have been debated for long. Growing evidence suggests that ABO blood group may play a role in the immunopathogenesis of SARS-CoV-2 infection. The level of evidence supporting an association between ABO type and COVID-19 ranges from small observational studies, to genome-wide-association-analyses and country-level meta-regression analyses. We tried to find out the molecular relations of SARS-CoV-2 infection and ABO blood groups. We discussed inherited associations and possible molecular mechanisms that drive the relationship between blood type and COVID-19. Similar and non-similar comments and demonstrations from several studies are simply notified here.

Bangladesh J Med Microbiol 2020; 14 (2): 30-35
Fleming’s Warning and the future pandemic
Authors: Jhora Sanya Tahmina
Published: January 2022

Abstract not available

Bangladesh J Med Microbiol 2021; 15 (2): 1-4
Focal Cortical Dysplasia as Cause of Refractory Epilepsy- A Case Report
Authors: Saha Sujan , Al Muzahid Md Abdullah , Chowdhury Ashish , Hasan Mehedi , Roy Uttam , Kabir Md Suman , Islam Md Rafiqul
Published: January 2022

Focal Cortical Dysplasia (FCD) is one of the most common causes of refractory epilepsy in children as well as adult where malformed cortical development occurs resulting from abnormal neuronal migration due to both genetic and acquired factors. Herein, a 22-year-old male presented with recurrent secondary generalized tonic seizure with aura since childhood. Despite adequate anti-epileptic medications with good compliance the seizure was uncontrolled. As a cause, Type II FCD was diagnosed by specific neuroimaging findings supported by EEG abnormalities. Till now in refractory epilepsy FCD is rarely diagnosed but there remains a good hope of cure by surgical intervention.

Bangladesh Journal of Neuroscience 2019; Vol. 35 (1): 46-50
Metabolismo urbano e gestão de resíduos sólidos: um diálogo necessário à gestão de cidades
Authors: Magalhães Rafaela Cajado , Santos Ana Cristina Batista dos , Buarque Brenno , Machado Herus Orsano , Carvalho Hermano José Batista de
Published: January 2022

Este trabalho foi desenvolvido com o objetivo de compreender a influência do conceito de Metabolismo Urbano (MU) nas estratégias utilizadas para a gestão de resíduos sólidos em duas cidades da Região Metropolitana de uma capital do nordeste brasileiro. A metodologia utilizada foi de cunho qualitativo, por meio da análise de conteúdo de 4 entrevistas individuais realizadas em profundidade. Na análise dos resultados, verificou-se que a influência do conceito de MU nas estratégias utilizadas para a gestão de resíduos sólidos nas cidades estudadas é mínima ou ausente, visto que, os gestores públicos envolvidos estão alheios, ou pouco sabem a respeito do conceito em estudo, demonstrando, portanto, uma visão reducionista da gestão de resíduos sólidos. Assim, limitam suas práticas ao serviço de coleta e disposição final de resíduos sólidos.
Sustentabilidade em tempos de pandemia: uma análise hoje para um novo fazer amanhã
Authors: Lima Jorcelyo Alencar , Alencar Elisangela de Andrade Borges , Fonseca Graicy Cavalcante
Published: January 2022

Sustentabilidade em tempos de pandemia: uma análise hoje para um novo fazer amanhã veicula uma análise epistemológica e conceitual sobre Sustentabilidade, contemplando os seus diversos ambientes de atuação, desde às ideias iniciais, até esse momento ímpar na história da humanidade: a pandemia causada pelo Covid-19. As questões se inserem na ressignificação de Sustentabilidade em contexto de pandemia, onde alguns aspectos ambientais foram beneficiados pelo isolamento social, como o ar, a água, os rios e oceanos; mas por outro lado, uma das principais consequências foi a questão do lixo que, não sendo mais produzido na rua, nas escolas e universidades, nos restaurantes, se acumularam nas casas, formando um grande problema ambiental e social. Para as empresas, esse momento de pandemia se estabelece como um momento oportuno para  agregar novos valores e impactar com serviços e produtos, desde que usem estratégias eficazes para a contenção dos dejetos produzidos. Por fim, o universo de ações urgentes  e necessárias para que se possa ter e garantir vida sustentável, no seu conceito mais lato, contemplando todas as dimensões da vida humana parecem ter nascidas ou adquirido consistência com a tão depredadora crise sanitária do Covid-19, pois toda  a humanidade,  de forma consciente ou inconsciente,  estão mudando hábitos e comportamentos, buscando estratégias para uma maior qualidade de vida e  promovendo, dessa forma, a sustentabilidade do Planeta para esta para as gerações futuras.
Anosmia as a clinical predictor to non-fatal COVID-19 case and better survivability
Authors: Weisnawa I Gede Purna , Susilawathi Ni Made , Purnamasidhi Cokorda Agung Wahyu , Purnama Giovanca Verentzia , Adiputra I Komang Hotra , Suteja Richard Christian , Jerry Jerry , Wulandari Putu Kintan
Published: January 2022

Recently, a respiratory infectious disease labeled as COVID-19 caused by SARS-CoV-2 had taken over the world by storm. This RNA virus can cause various symptoms such as malaise, anosmia, ageusia, fever, cough, headache, myalgia, diarrhea, and ARDS. COVID-19 patients have specific symptoms such as fever. In another study, it was said that anosmia could be a benchmark for screening for COVID-19. in a study of young patients and was more common in women. The average onset of anosmia occurs on day 4 after infection and lasts for 8 days. the evidence says that this disease can cause a decrease in a person's quality of life. The exact cause of anosmia is still unknown, but several theories suggest that anosmia can occur due to damage to nerve receptors, inflammation of olfactory epithelial cells, and dysfunction of nerve receptors. The popular theory is that anosmia occurs due to inflammation of the olfactory epithelial cells, thereby damaging the olfactory receptors. The inflammation blocks odors from reaching the nasal mucosa and can inhibit receptor excitability and signal transduction. Anosmia may be associated with lower hospital mortality rates. However, further research and discovery is needed to fully grasp the pathophysiological concept of COVID-19 induced anosmia. This review will discuss the pathophysiology and review the lower anosmia mortality rate. This article reviews current understandings about the pathophysiology of anosmia and its potential as a marker towards better clinical prognosis. This narrative review aims to provide knowledge about updates regarding the pathophysiology of anosmia as a clinical predictor of mild and severe COVID-19 symptoms.
Alteração da terapia antirretroviral: inefetividade ou insegurança?
Authors: Mesquita Diego Pinheiro , Araújo Andressa Silva , Mourão Erika Maria Siqueira , Romeu Geysa Aguiar
Published: January 2022

O objetivo do estudo foi analisar as alterações da terapia antirretroviral de pacientes atendidos em uma unidade dispensadora de medicamentos de Fortaleza, Ceará. Realizou-se estudo observacional, documental, descritivo, retrospectivo, com abordagem quantitativa, no período de janeiro a maio de 2020. Incluíram-se todos os portadores de HIV/AIDS, cadastrados na unidade dispensadora de medicamentos, com idade igual ou superior a 18 anos que realizaram mudanças na terapia antirretroviral no período de janeiro a dezembro de 2019. Excluíram-se os usuários que mudaram de unidade durante esse período. Predominaram pessoas do sexo masculino, faixa etária entre 31 a 40 anos, pardos, solteiros, com escolaridade correspondente do ensino médio ao ensino superior, naturais e procedentes de Fortaleza, com tempo de diagnóstico entre 1 e 5 anos. Foram registradas 24 combinações diferentes de terapia antirretroviral, sendo a associação mais utilizada com tenofovir, lamivudina e efavirenz. Dos motivos que levaram à mudança de terapia antirretroviral, prevaleceram a incidência ou risco de reação adversa ao medicamento, início ou fim da gestação e facilitação da adesão ao tratamento. O efavirenz foi o principal medicamento envolvido nas suspeitas de reação adversa, seguido pelo tenofovir. Conclui-se que os dados obtidos auxiliaram na compreensão do perfil das pessoas vivendo com HIV de uma Unidade Dispensadora de Medicamentos de Fortaleza e as causas para mudança da terapia antirretroviral.
Production of biosurfactants by Mucoralean fungi isolated from Caatinga bioma soil using industrial waste as renewable substrates
Authors: Cândido Thayná Rhomana da Silva , Mendonça Rafael de Souza , Lins Uiara Maria de Barros Lira , Souza Adriana Ferreira de , Montero Rodriguez Dayana , Campos-Takaki Galba Maria  de , Andrade Rosileide Fontenele da Silva
Published: January 2022

In this work it was investigated the potential of Mucorales fungi isolated from the Caatinga of Pernambuco state for production of biosurfactants using renewable substrates. The strains (Mucor circinelloides UCP 0005, M. circinelloides UCP 0006 and Rhizopus arrhizus UCP 1609) were cultivated in alternative culture media consisting of instant noodle waste (INW), corn steep liquor (CSL) and post-frying soybean oil (PFSO), according to conditions established by a 23 full-factorial design (FFD). The production of biosurfactants was evaluated by determining surface tension and emulsification index (EI24) and statistical analysis was performed using Pareto diagram. The presence of the main sources of carbon and nitrogen in production medium was confirmed by FTIR spectroscopy. According to the results, the three fungi evaluated were able of produce biosurfactant in media containing renewable sources. However, the strain that showed the greatest reduction in surface tension (72 to 27 mN/m) was M. circinelloides UCP 0006 in condition 3 of the FFD (1% INW and 4% CSL, in absence of PFSO). The infrared analysis of the INW showed the presence of carbohydrates, fatty acids and proteins, proving that this is a suitable substrate for the cultivation of fungi. The biosurfactants produced by M. circinelloides UCP 0005 and M. circinelloides UCP 0006 were able to form water-in-oil emulsions and the biosurfactant from R. arrhizus UCP 1609 formed oil-in-water emulsions. The present study demonstrated that the three Mucorales fungi tested were able to produce biosurfactants from renewable sources, with emphasis on M. circinelloides UCP 0006.
Macrófitas e seu potencial fitorremediativo em estações de tratamento de esgoto: uma revisão bibliográfica
Authors: Ferreira Micaella Assad , Lopes Thais Costa , Nascimento Dryelle de Nazaré Oliveira do , Castro Ana Paula Simões
Published: January 2022

Na atualidade o município de Belém conta com apenas 0,78% dos esgotos tratados, ressaltando que a capital sempre apresentou escassez no sistema de saneamento básico. Diante disto, podemos perceber as dificuldades existentes nesse setor, que é de extrema importância pra qualidade de vida da sociedade e para o meio ambiente como um todo. Logo, o presente trabalho tem como objetivo estudar o potencial fitorremediativo de macrófitas, analisando a possibilidade de inserção em ETE’s. A pesquisa será desenvolvida através de uma revisão de literatura para consultar quais plantas são mais viáveis para inserção em estações de tratamento de esgoto, analisando vários quesitos relevantes para tal. Por meio desta pesquisa pretende-se obter resultados positivos que possam ser aplicados futuramente em ETE’s e tragam benefícios para o meio ambiente e para a sociedade no geral, além de trazer informações e esclarecimentos sobre a técnica de fitorremediação, que está sendo cada vez mais utilizada no Brasil.
Molecular and serological diagnostic of leptospirosis: a review (2014–2020)
Authors: Padilha Bárbara Couto Roloff , Silveira Marcelle Moura , Hartwig Daiane Drawanz
Published: January 2022

Leptospirosis is a zoonosis caused by pathogenic bacteria of the genus Leptospira. This disease affects several animals and humans. Symptoms of leptospirosis can range from mild to severe, may in some cases lead to death. For the diagnosis of leptospirosis, the microscopic agglutination test is considered the “gold standard”; however, it has limitations and studies are being conducted to develop alternative methods of screening and diagnosis of leptospirosis. Serological and immunochemical tests using Leptospira recombinant antigens in combination to molecular tests may be an alternative. In this study, we reported the advances achieved from 2014 until 2020 in controlling leptospirosis based on serological tests using recombinant antigens and molecular diagnosis.
Educação inclusiva no ensino remoto emergencial
Authors: Tavares Márcio Jean Fernandes , Ferraz Júlia Maria Soares , Souza Niely Silva de , Figueirêdo Alessandra Marcone Tavares Alves de , Silva Júnior Carlos Alberto da
Published: January 2022

A pandemia do novo coronavírus intensificou diversas problemáticas educacionais e, com isso, o Ensino Remoto Emergencial surgiu como uma alternativa para a resolução desses impasses. Contudo, essa estratégia contribuiu para a construção de diversas barreiras de ensino, entre elas, se destaca a carência na promoção de métodos voltados aos princípios de uma Educação Inclusiva para todos. Assim, o presente artigo teve como objetivo a aplicação de um software que facilita a visualização do Tradutor Intérprete da Língua de Sinais (TILS), sendo aquele um recurso que evita o excesso de informação visual e permite a exibição simultânea do TILS com o material de aula apresentado. O processo metodológico teve um perfil qualitativo que passou pela validação de um estudante surdo, apresentando resultados satisfatórios, indicando a importância da ampliação da inclusão no trabalho docente, tal como a necessidade de incentivos ao avanço de estudos nesta importante área que muitas vezes é esquecida.
Informatização na cadeia produtiva da piscicultura brasileira: inovações tecnológicas em softwares, aplicativos, programas de monitoramento e rastreabilidade
Authors: Marmentini Regiane Pandolfo , Silva Lidiane França da , Dantas Filho Jerônimo Vieira , Porto Marlos Oliveira , Cavali Jucilene
Published: January 2022

O pescado produzido na aquicultura tem sido fundamental para o abastecimento global de proteína animal na alimentação humana. No Brasil a aquicultura vem crescendo e para que se consolide se faz necessária a informatização no processo de produção do pescado no campo, no processamento que ocorre na indústria desde o recebimento da matéria prima até a expedição do produto acabado e no setor de distribuição desses produtos, com destaque para a rastreabilidade. Diante disso, o objetivo do estudo foi realizar levantamento de dados sobre a disponibilidade de sistemas informatizados na cadeia produtiva do pescado brasileiro, buscando por inovações tecnológicas, softwares, aplicativos, programas de monitoramento e rastreabilidade. Existem tecnologias disponíveis para a aquicultura como é o caso da identificação eletrônica dos peixes, dos aplicativos para o processo de produção, dos softwares como AgroPesca na indústria e Alumi Pescados no setor de distribuição do pescado e dos códigos bidimensionais (QR Code) que tem sido utilizados para fornecer aos consumidores informação rápida sobre os produtos adquiridos. Com a aplicação de novas tecnologias no setor, os mercados consumidores tendem a ter maior confiança em adquirir o pescado brasileiro.
Interculturalidade nas licenciaturas: ressignificando práticas docentes e saberes do campo
Authors: Oliveira Renata Moraes de , Pontes Paulo André Ignacio , Seruffo Marcos César da Rocha
Published: January 2022

A Educação do campo e os saberes interculturais são elementos indissociáveis para uma educação transformadora, sob essa premissa a pesquisa pretende problematizar a formação inicial de professores e prover discussões sobre as mudanças necessárias às práticas pedagógicas para o ensino básico do campo. Diante disso, temos como ponto de partida a seguinte questão: Como vem sendo realizada essa interculturalidade nas práticas docentes? Como objetivos específicos, a pesquisa propõe-se a identificar o que vem sendo discutido academicamente nos periódicos CAPES sobre as práticas pedagógicas para educação básica, bem como analisar como a formação inicial sob a ótica intercultural reflete sobre as práticas pedagógicas e assim confrontar as bases norteadoras oficiais e seus caminhos teórico-práticos. A metodologia empregada é de cunho qualitativo e bibliográfico com análise de conteúdo de uma revisão sistemática da literatura (RSL), no site do periódico CAPES, acerca de práticas pedagógicas desenvolvidas na educação básica do campo; seguido por aplicação de questionário semiestruturado a professores do campo. Os resultados apontam que as pesquisas voltadas às práticas ativas no ensino fundamental ainda requerem maiores investigações e que propostas interculturais demonstram melhores resultados quanto ao engajamento, senso de pertencimento e ressignificação de saberes escolares.
O efeito de fórmulas nutricionais utilizadas no tratamento de crianças com alergia à proteína do leite de vaca: uma revisão sistemática
Authors: Moura Rayane Carvalho de , Costa Crislane de Moura , Brito Marilene Magalhães de , Santos Marcos Antônio Pereira dos , Brandão Amanda de Castro Amorim Serpa , Freitas Betânia de Jesus e Silva de Almendra , Paiva Adriana de Azevedo
Published: January 2022

Introdução: A literatura tem evidenciado um aumento na prevalência de crianças com alergia à proteína do leite de vaca (APLV) e o seu tratamento consiste em retirar esse alimento e seus derivados da dieta e na substituição por fórmulas à base de proteína isolada de soja ou de fórmulas hidrolisadas. Objetivo: Avaliar os efeitos do uso de fórmulas nutricionais em crianças com APLV. Metodologia: A busca e seleção dos artigos seguiram as recomendações do Preferred Reporting Items for Systematic Reviewsand Meta-Analyses (PRISMA), utilizou-se as palavras-chaves: “milk hypersensitivity”, “food hypersensitivity, hydrolyzed”, “vegetal protein”, “vegetal protein”, “soy bean proteins” em combinação ou isoladas, nas bases de dados Pubmed, Scopus e Science direct. Resultados: Nove artigos foram incluídos, sendo seis ensaios clínicos, um estudo de coorte, um estudo observacional e um estudo multicêntrico. Foram testadas: fórmula de proteína extensamente hidrolisada, fórmula à base de aminoácidos e fórmula à base de soja. Sendo que em 3 estudos as fórmulas de proteína extensamente hidrolisada e a de aminoácidos foram associadas com probióticos Lactobacillus rhamnosus e tiveram 2 estudos associados com simbióticos. Conclusão: Todos os tipos de fórmulas analisadas contribuíram para melhora nos sintomas relacionados a APLV, sendo os melhores resultados observados para as fórmulas com probióticos. No entanto, são necessários mais estudos que avaliem os efeitos dos probióticos adicionados em fórmulas nutricionais para o tratamento de APLV, seu potencial precisa ser melhor avaliado, principalmente em estudos a longo prazo.
Laserterapia de baixa potência aplicada em lesões labiais de paciente em condição grave: relato de caso
Authors: Ota Luiza Elias , Santana Gabriel Umbelino , Nejaim Yuri , Gaetti-Jardim Ellen Cristina
Published: January 2022

A associação entre a Síndrome da Imunodeficiência Adquirida e as manifestações bucais, embora já bastante conhecida, ainda apresenta situações desafiadoras. Seja ocasionada ou potencializada pela doença, as alterações bucais são uma realidade e para tanto é objetivo deste trabalho relatar e discutir o caso de um paciente de 45 anos, sexo masculino, internado no Hospital Universitário Maria Aparecida Pedrossian com diagnóstico de doença pelo vírus da imunodeficiência humana (HIV), epilepsia e tetraplegia, de evolução grave. Fazendo uso de ventilação mecânica e demais cuidados paliativos, o mesmo passou a apresentar úlceras e lesões sangrantes em mucosa labial, de modo que a equipe médica solicitou o parecer da odontologia hospitalar. Para o manejo dessas feridas foi estabelecido, então, o protocolo de laserterapia de baixa frequência, dividido em 05 aplicações, para propiciar uma melhor biomodulação e regeneração do tecido afetado, diminuindo, assim, a morbidade do paciente. Ao final da última sessão, os resultados foram satisfatórios, evidenciando a eficácia do tratamento coadjuvante com laser de baixa frequência em lesões orais. Mesmo com as dificuldades inerentes ao tratamento e diagnóstico do HIV e suas manifestações, diminuir a sintomatologia do paciente é também um dever da Odontologia, assim, os resultados alcançados com a terapêutica empregada foram satisfatórios e devolveram alguma qualidade de vida ao paciente neste momento tão desafiador.
Microrganismo endofíticos para conservação de produtos hortícolas
Authors: Franco Marcos Fabian Sanabria , Jacomino Angelo Pedro , Spricigo Poliana Cristina , Ramos Diana Gissell Barreto , Oliveira Juliana Elias de , Florêncio Mariana Trevisan , Oliveira Junior Marcelo Almeida de , Milan Rodrigo José , Kluge Ricardo Alfredo
Published: January 2022

A perda de alimento de frutas e hortaliças causadas por doenças pós-colheita é um grande problema no mundo. Dentro da planta, acontecem vários fenômenos referentes às atividades endófitos microbianas, começando desde a estimulação direta do crescimento da planta pela ação de fitohormônios ou pela produção de metabólitos como mecanismo de defesa no vegetal. Conhecer a comunidade microbiana auxilia no manejo de prevenção de distúrbios fisiológicos e doenças após-colheita. Mediante a revisão das literaturas, foram observados os mecanismos de biocontrole de microrganismos, a ação da maioria dos patógenos mais comuns, os gêneros de microrganismos de interesse comercial e a perspectiva de microrganismos endofíticos para o futuro na pós-colheita de frutas e hortaliças. Conclui-se que a demanda global por alimentos mais saudáveis está em auge, pelo o controle de doenças através de microrganismo endofíticos é uma realidade na pós-colheita e é um desafio para as próximas pesquisas na obtenção de maiores benefícios ecológico.
Variabilidade urbana em Recife - PE, por meio das contribuições: precipitação, temperatura e umidade relativa do ar
Authors: Medeiros Raimundo Mainar de , Holanda Romildo Morant de , França Manoel Vieira de , Saboya Luciano Marcelo Falle , Cunha Filho Moacyr , Araújo Wagner Rodolfo de
Published: January 2022

Objetiva-se estudar a variabilidade urbana, por meio das contribuições dos índices pluviométricos, temperaturas e umidade relativa do ar, comparando-se os períodos 1931-1960; 1961-1990 e 1991-2016 para a precipitação e os períodos de 1962-1990 e de 1991-2016 para temperatura e umidade relativa do ar com as médias de 1931-2016 e 1962-2016 respectivamente, procurando quantificar as alterações climáticas e identificar a influência de eventos climáticos de larga escala El Niño(a), visando contribuir com os gestores responsáveis pelo planejamento urbano e melhoria da qualidade de vida dos habitantes e do ecossistema. Foram utilizados os dados das precipitações, temperaturas e umidade do ar, do Instituto Nacional de Meteorologia (INMET). Foram calculados parâmetros estatísticos básicos assim como as variações das anomalias anuais com objetivo de identificar flutuabilidade nos dados e a influência de eventos extremos. Estas flutuações nos índices pluviométricos registrados nos períodos de 1931-1960; 1961-1990 e 1991-2016 poderão estar relacionados aos seguintes fatores ou fatos: A expansão do município tanto na vertical como na horizontal; a troca do local do pluviômetro do meio urbano para próximo da zona da mata e próximo ao rio; e devido à arborização urbana. A cidade do Recife sofreu com o crescimento desordenado, sem padrões específicos de planejamento na urbanização que provocaram variações no microclima da urbis, acarretando desconforto térmico e redução da qualidade de vida dos seus habitantes. Registra-se intenso fluxo de veículos automotivos e pessoas durante todo dia decorrente de atividades relativas a trabalho, comércio e serviços, além da concentração de várias construções, áreas impermeabilizadas bem como edifícios dificultando a circulação do ar local. Sugere-se aumento de áreas verdes interbairros a partir da arborização que vem se mostrando como alternativa para a melhoria da qualidade de vida nos espaços urbanos.
Analisis Kerusakan Jaringan Insang Ikan Mas (Cyprinus carpio L.) Setelah Terpapar Pestisida Klorpirifos
Authors: Amaliyah Viki , Santoso Hari , Syauqi Ahmad
Published: January 2022

The use of chlorpyrifos pesticide as an agricultural pest exterminator if excessive and carried out continuously can have a large negative impact on biotic and abiotic life. Fish as one of the environmental bioindicators of pesticide contamination, because the gill organs will receive chemical effects in taking oxygen in pesticide-contaminated water ponds. The purpose of this study was to analyze the level of damage to the gill tissue of carp (Cyprinus carpio) exposed to the pesticide chlorpyrifos at various concentration levels. This research was carried out at the Punten Freshwater Cultivation Installation, Batu City, East Java. Using the experimental method with concentrations of acute toxicity treatment (LC50) namely K1 0.25 ppm, K2 0.30 ppm, K3 0.35 ppm, K4 0.40 ppm, K5 0.45 ppm. The research data were analyzed descriptively in the form of tables and graphs. The results of the preliminary acute toxicity test (LC50) were in the range of K1 0.25 ppm and K2 0.30 ppm. Furthermore, Alizarin Red staining was performed to give color to the gills. The results of acute toxicity test (LC50) Total percentage of damage at a concentration of 0.25 ppm 22.28% and a concentration of 0.30 ppm 77.54%. Damage to gill tissue exposed to the pesticide chlorpyrifos showed an acute level occurred at a concentration of 0.30ppm, where the higher the concentration, the higher the gill damage.Keywords: Chorphyrifos Pesticide, Cyprinus carpio,  Precentage of DamageABSTRAKPenggunaan pestisida klorpirifos sebagai pembasmi hama pertanian bila berlebihan dan dilakukan secara terus menerus dapat menimbulkan dampak negatif yang besar bagi kehidupan biotik dan abiotik. Ikan sebagai salah satu bioindikator lingkungan tercemar pestisida, karena organ insang akan menerima efek kimiawi dalam mengambil oksigen pada kolam perairan yang tercemar pestisida. Tujuan penelitian ini adalah untuk menganalisis tingkat kerusakan jaringan insang ikan mas (Cyprinus carpio) yang terpapar pestisida klorpirifos pada berbagai level konsentrasi. Penelitian ini dilaksanakan di Instalasi Budidaya Air Tawar Punten, Kota Batu, Jawa Timur. Menggunakan metode eksperimen dengankonsentrasi perlakuan toksisitas akut (LC50) yaitu K1 0,25 ppm, K2 0,30 ppm, K3 0,35 ppm, K4 0,40 ppm, K5 0,45 ppm. Data penelitian dianalisis secara deskriptif dalam bentuk Tabel dan Grafik. Hasil uji pendahuluan toksisitas akut (LC50) berada pada kisaran K1 0,25 ppm dan K2 0,30 ppm. Selanjutnya dilakukan pewarnaan Alizarin Red untuk memberi warna pada insang. Hasil uji toksisitas akut (LC50) Total presentase kerusakan pada konsentrasi 0,25 ppm 22,28% dan konsentrasi 0,30 ppm 77,54%. Kerusakan jaringan insang yang terpapar pestisida klorpirifos memperlihatkan tingkat akut terjadi pada perlakuan konsentrasi 0,30ppm, dimana semakin tinggi konsentrasi akan semakin tinggi kerusakan insang.Kata kunci : Pestisida Klorpirifos, Cyprinus carpio, Kerusakan Insang.
Pengaruh Pemberian Jamu Herbal Terhadap Pembentukan Otot Tendon Sapi Kerapan Madura (Bos primiginius)
Authors: Jailani Ach , Santoso Hari , Zayadi Hasan
Published: January 2022

This study aims to determine the effect of giving herbal ingredients on the muscle formation of the tendons of the Madura bullock cattle (Bos primiginius). The method used in this study was carried out by surveys and measurements in the field. Sampling of locations and cattle using purposive sampling, namely bulls are taken at locations that have potential for bullocks. The vital statistics were calculated using the incidental sampling method. The results showed that the provision of herbal concoctions of temu lawak, temu ireng, turmeric, black coffee ginger, galangal, and ginseng can increase stamina so as to speed up running cows, then herbal medicine is significant in the formation of tendon muscles. It is proven that the formation of muscle tendons is correlated with increasing running speed as evidenced by the results of increasing running speed of 17.15/second within a distance of 221 meters so that it can be concluded that herbal medicine is significant for the formation bovine tendon muscles.Keywords: Jamu Herbal, Madura Kerapan Cow, Tendon MusclesABSTRAKPenelitian ini bertujuan untuk mengetahui pengaruh pemberian ramuan herbal terhadap pembentukan otot tendon sapi kerapan Madura (Bos primiginius). Metode yang digunakan dalam penelitian ini dilakukan dengan survey dan pengukuran di lapang. Sampling lokasi dan ternak sapi menggunakan purposive sampling yaitu sapi kerapan diambil pada lokasi yang potensial sapi kerapan. Data dihitung statistik vital menggunakan metode insidental sampling. Hasil didapatkan menunjukkan bahwa Pemberian ramuan herbal temu lawak,temu ireng, kunyit, jahe kopi hitam, lengkuas,dan gingseng dapat menambah stamina sehingga mempercepat lari sapi, maka jamu herbal signifikan dalam pembentukan otot tendon hal ini terbukti bahwa pembentukan otot tendon berkolerasi dengan penambahan kecepatan lari dibuktikan dengan hasil bertambahnya kecepatan lari 17.15/Detik dalam jarak 221 Meter sehingga dapat disimpulkan bahwa jamu herbal signifikan terhadap pembentukan otot tendon sapi kerapan.Kata kunci : Jamu Herbal, Sapi Kerapan Madura, Otot Tendon
Hubungan Permainan Outbound dengan Perkembangan Sosial Anak di taman Kanak-kanak Kecamatan Padangsidimpuan Utara
Authors: Latifah Rahmy , Marlina Serli
Published: January 2022

Penelitian ini bertujuan untuk mengetahui hubungan permainan outbound dengan perkembangan sosial anak di Taman Kanak-kanak  Kecamatan Padangsidimpuan Utara. Metode Penelitian yang digunakan adalah kuantitatif yang berbentuk korelasi dengan Teknik pengambilan sampel yaitu dengan cara gugus (cluster sampling). Hasil Penelitian terlihat bahwa terdapat hubungan antara permainan outbound dengan perkembangan sosial anak di Taman Kanak-kanak Kecamatan Padangsidimpuan utara sebesar 85%. Dapat disimpulkan bahwa permainan outbound memiliki hubungan terhadap perkembangan sosial anak.
Who Was Who in the Aether of the Weimar Republic? Tracing the Callbooks That Never Existed
Authors: Sommer Friedrich T. , Hamperl Steffen , Hoyer Gerd
Published: January 2022

A listing of amateur radio operators is provided who actively transmitted on shortwave during the Weimar Republic in Germany (1924-1933). Some biographical information is added, when available. Such a listing never existed before because transmissions were clandestine. It is helpful for researching the history of electrical engineering and radio in this period. The listing is subdivided by different time periods between which the call sign system changed. Each time period contains separate alphabetical lists of official (“lis”) and unofficial (“unlis”) calls. For reference we added also a list of the calls EK4/D4 operators and DE listeners held after 1949. D4 and DA calls in the period from 1933-1948 are included, when known, but not alphabetically listed.(1) 1927-1930: 1a) EK4xxx/D4xxx – “lis”; 1b) EK4xx/D4xx – “unlis”; 1c) Foreign calls of EK/D stations(2) 1930-1933: 2a) D4xxx – “lis”; 2b) D4xxx – “unlis”; 2c) Foreign calls of EK/D stations; 2d) Arbeiterempfangsdienst SWLs(3) 1924-1927: 3a) KA0-KZ9 – “lis”; 3b) Freestyle calls – “unlis”; 3c) Occupational forces; 3d) Official freestyle calls(4) After 1949: Post-WW2 calls of EK/D stations and holders of DE numbers (< DE6000)
Religious Minorities and the Graduate School Experience
Authors: Davis Thomander Sierra , Malji Andrea
Published: January 2022

This chapter examines challenges facing graduate students who are broadly-defined religious minorities. We examine prevailing concerns including dietary accommodations, socialization, and cultural and holiday/calendar differences. Within political science specifically, students may need to navigate representing/defending their religion, especially if colleagues study their religion. Religious minorities may face discrimination as well as outright harassment and assault. Students should feel empowered to advocate for their rights and respectful treatment. Graduate school may also have certain socialization norms that are counter to the beliefs of certain religions, such as centering socialization around alcohol. We provide several recommendations about using university resources, establishing boundaries, and proactively advocating for your religious needs. We conclude with best practices for all graduate students that will foster inclusion and respect. This manuscript is part of Strategies for Navigating Graduate School and Beyond, a forthcoming volume for those interested in pursuing graduate education in political science (Fall 2022 publication).
Heterotopic Ossification: Clinical Features, Basic Researches, and Mechanical Stimulations
Authors: Xu Yili , Huang Mei , He Wenzhen , He Chen , Chen Kaixuan , Hou Jing , Huang Min , Jiao Yurui , Liu Ran , Zou Nanyu , Liu Ling , Li Changjun
Published: January 2022

Heterotopic ossification (HO) is defined as the occurrence of extraskeletal bone in soft tissue. Although this pathological osteogenesis process involves the participation of osteoblasts and osteoclasts during the formation of bone structures, it differs from normal physiological osteogenesis in many features. In this article, the primary characteristics of heterotopic ossification are reviewed from both clinical and basic research perspectives, with a special highlight on the influence of mechanics on heterotopic ossification, which serves an important role in the prophylaxis and treatment of HO.
Aortic Coarctation Associated With Hypertrophic Cardiomyopathy in a Woman With Hypertension and Syncope: A Case Report With 8-Year Follow-Up
Authors: Yang Hong , Wang Hong , Li Zongzhe , Yan Jiangtao , Song Yu-E , Zeng Hesong , He Xingwei , Li Rui , Wang Dao Wen
Published: January 2022

Background

Coarctation of the aorta (CoA) is a common congenital cardiovascular malformation with aortic narrowing in the region of the ligamentum arteriosum. Hypertrophic cardiomyopathy (HCM) is a primary cardiomyopathy that is characterized by left ventricular wall thickening and likely left ventricular outflow tract (LVOT) obstruction. They are two irrelevant diseases, and their coexistence has not been reported before. Here, we described a young female patient who concurrently has CoA and HCM.

Case Presentation

The patient has had hypertension since 18-years old and complained of chest discomfort on effort and fatigue thereafter. Initially, she was diagnosed as having hypertrophic cardiomyopathy and primary hypertension. The presence of CoA was not found until she was 35 years old when she had an onset of paroxysmal supraventricular tachycardia (PSVT) and presented with syncope. Failure of the ablation procedure via the femoral artery revealed the possibility of CoA and PDA that was confirmed by aortic CTA and angiography. CoA was then treated successfully with a covered stent, and the symptoms of the patient improved remarkably. Additionally, the patient had typical imaging features of HCM, and two novel HCM-causing heterozygous mutations were identified by genetic testing, DSP-encoding desmoplakin, and MYBPC3-encoding myosin-binding protein C. The HCM was suspected to be contributing to the clinical presentations of the patient and challenged the timely diagnosis of CoA. The 8-year follow-up on aortic CTA and angiography revealed no stent graft-related complications. Moreover, no changes in HCM-related imaging features were found in the follow-up echocardiography 8 years after the correction of aortic coarctation, which strengthened the diagnosis of HCM.

Conclusion

Here, we reported the diagnostic challenges, management, and 8-yeasr follow-up findings in a rare case of CoA combined with HCM. The case highlighted the importance for physicians to exclude CoA in young hypertensive patients, and proved the efficacy of stent repair in treating CoA in older patients.
Cumulative Evidence for the Association of Thrombosis and the Prognosis of COVID-19: Systematic Review and Meta-Analysis
Authors: Xiao Dongqiong , Tang Fajuan , Chen Lin , Gao Hu , Li Xihong
Published: January 2022

Background

Although thrombosis events have been reported in patients with coronavirus disease 2019 (COVID-19), the association between thrombosis and COVID-19-related critical status or risk of mortality in COVID-19 has been inconsistent.

Objective

We conducted a meta-analysis of reports assessing the association between thrombosis and the prognosis of COVID-19.

Methods

The EMBASE, Ovid-MEDLINE, and Web of Science databases were searched up to December 9, 2021, and additional studies were retrieved via manual searching. Studies were included if they reported the risk of COVID-19-related critical status or COVID-19-related mortality in relation to thrombosis. The related data were extracted by two authors independently, and a random effects model was conducted to pool the odds ratios (ORs). In addition, stratified analyses were conducted to evaluate the association.

Results

Among 6,686 initially identified studies, we included 25 studies published in 2020 and 2021, with a total of 332,915 patients according to predefined inclusion criteria. The associations between thrombosis and COVID-19-related mortality and COVID-19-related critical status were significant, with ORs of 2.61 (95% CI, 1.91–3.55, p < 0.05) and 2.9 (95% CI, 1.6–5.24, p < 0.05), respectively. The results were statistically significant and consistent in stratified analyses.

Conclusions

Thrombosis is associated with an increased risk of mortality and critical status induced by COVID-19. Further prospective studies with large sample sizes are required to establish whether these associations are causal by considering more confounders and to clarify their mechanisms.

Observational studies cannot prove causality. However, autopsy studies show thrombosis events preceding COVID-19-related deaths. The results of this meta-analysis reported that thrombosis was associated with a 161% increased risk of mortality from COVID-19 and a 190% increased risk of COVID-19-related critical status. The type of thrombosis included in the original studies also seemed to be related to the results.
Research on Coal Acoustic Emission Characteristics and Damage Evolution During Cyclic Loading
Authors: Zhili Su , Shengguo Jing , Wenbing Xie , Qingteng Tang
Published: January 2022

The acoustic emission, energy, and damage evolution of coal samples for three kinds of uniaxial cyclic loading and unloading are deeply analyzed in this study. The evolution of total absorption energy, elastic strain energy, and dissipated energy of coal samples is related to the stress path, and the increasing amplitudes cycle loading has an obvious damage effect on coal samples. During the loading stage, the acoustic emission phenomenon is most active when loading is increasing and the Felicity and post-Kaiser phenomena appear. The acoustic emission phenomenon during constant loading does not obviously change, but rather becomes active with the increase of the equivalent load. The damage to the coal sample shows nonlinear change increasing loading and unloading and shows linear change for other stress paths. Compared to waveforms with stepwise increasing amplitudes cyclic loading, the failure process of the coal sample is more closely related to the size of the external load, which indicates that reasonable hydraulic design is beneficial to the stability of the confining pressure in the chamber of an underground pumped storage hydropower station.
Intestinal Barrier Function and Immune Homeostasis Are Missing Links in Obesity and Type 2 Diabetes Development
Authors: Riedel Sylvia , Pheiffer Carmen , Johnson Rabia , Louw Johan , Muller Christo J. F.
Published: January 2022

Noncommunicable diseases, such as type 2 diabetes (T2D), place a burden on healthcare systems worldwide. The rising prevalence of obesity, a major risk factor for T2D, is mainly attributed to the adoption of Westernized diets and lifestyle, which cause metabolic dysfunction and insulin resistance. Moreover, diet may also induce changes in the microbiota composition, thereby affecting intestinal immunity. The critical role of intestinal immunity and intestinal barrier function in the development of T2D is increasingly acknowledged, however, limited studies have investigated the link between intestinal function and metabolic disease. In this review, studies reporting specific roles of the intestinal immune system and intestinal epithelial cells (IECs) in metabolic disease are highlighted. Innate chemokine signaling, eosinophils, immunoglobulin A (IgA), T helper (Th) 17 cells and their cytokines were associated with obesity and/or dysregulated glucose homeostasis. Intestinal epithelial cells (IECs) emerged as critical modulators of obesity and glucose homeostasis through their effect on lipopolysaccharide (LPS) signaling and decontamination. Furthermore, IECs create a link between microbial metabolites and whole-body metabolic function. Future in depth studies of the intestinal immune system and IECs may provide new opportunities and targets to develop treatments and prevention strategies for obesity and T2D.
Contrasting Impacts of Climate Warming on Coastal Old-Growth Tree Species Reveal an Early Warning of Forest Decline
Authors: Mercer Catherine , Comeau Vanessa M. , Daniels Lori D. , Carrer Marco
Published: January 2022

Old-growth forests in the Pacific Northwest are being fundamentally altered by climate change. A primary example of this is yellow-cedar (Callitropsis nootkatensis), a culturally and economically important species, which has suffered widespread decline across its range since the beginning of the twentieth century. We used tree rings to compare the climate-growth response of yellow-cedar to two co-occurring species; western hemlock (Tsuga heterophylla) and Sitka spruce (Picea sitchensis), in an old-growth forest on Haida Gwaii, Canada, to better understand the unique climatic drivers of a species that is declining across its range. We developed three species-specific chronologies spanning 560–770 years, reconstructing a long-term record of species growth and dynamics over time. The climate is strongly influenced by the Pacific Decadal Oscillation (PDO), a multi-decadal pattern of ocean-atmospheric climate variability. Climate varied across three time periods that have coincided with major shifts in the PDO during the twentieth century [1901–1945 (neutral/positive), 1946–1976 (negative) and 1977–2015 (positive)]. Conditions were significantly warmer and wetter during positive phases, with the greatest maximum temperatures in the most recent period. We used complimentary methods of comparison, including Morlet wavelet analysis, Pearson correlations, and linear-mixed effects modeling to investigate the relations between climate and species growth. All three species exhibited multi-decadal frequency variation, strongest for yellow-cedar, suggesting the influence of the PDO. Consistent with this, the strength and direction of climate-growth correlations varied among PDO phases. Growing season temperature in the year of ring formation was strongly positively correlated to yellow-cedar and western hemlock growth, most significantly in the latter two time periods, representing a release from a temperature limitation. Sitka spruce growth was only weakly associated with climate. Yellow-cedar responded negatively to winter temperature from 1977 to 2015, consistent with the decline mechanism. Increased yellow-cedar mortality has been linked to warmer winters and snow loss. This study provides new insights into yellow-cedar decline, finding the first evidence of decline-related growth patterns in an apparently healthy, productive coastal temperate rainforest.
A Novel Immune-Related ceRNA Network and Relative Potential Therapeutic Drug Prediction in ccRCC
Authors: Li Weiquan , Meng Xiangui , Yuan Hongwei , Xiao Wen , Zhang Xiaoping
Published: January 2022

Renal cell carcinoma (RCC) is the third common solid tumor in the urinary system with a high distant metastasis rate. The five-year survival rate of RCC has reached 75%, benefiting from the emergence and update of multiple treatments, while its pathogenesis and prognostic markers are still unclear. In this study, we committed to explore a prognostic ceRNA network that could participate in the development of RCC and had not been studied yet. We screened nine immune-related hub genes (AGER, HAMP, LAT, LTB4R, NR3C2, SEMA3D, SEMA3G, SLC11A1, and VAV3) using data of The Cancer Genome Atlas Kidney Clear Cell Carcinoma database (TCGA-KIRC) through survival analysis and the cox proportional hazard model. Next, we successfully constructed a ceRNA network of two mRNA (NR3C2 and VAV3), miRNA (hsa-miR-186-5p), and lncRNA (NNT-AS1) for ccRCC based on numerous online bioinformatics tools and Cytoscape. Finally, we predicted five potential drugs (clemizole, pentolonium, dioxybenzone, Prestwick-691, and metoprolol) based on the above results.
Regulatory Mechanism of lncRNAs in M1/M2 Macrophages Polarization in the Diseases of Different Etiology
Authors: Jiang Ping , Li Xiaopeng
Published: January 2022

Precise expression and regulation of genes in the immune system is important for organisms to produce strong immunity towards pathogens and limit autoimmunity. In recent years, an increasing number of studies has shown that long noncoding RNAs (lncRNAs) are closely related to immune function and can participate in regulating immune responses by regulating immune cell differentiation, development, and function. As immune cells, the polarization response of macrophages (Mφs) plays an important role in immune function and inflammation. LncRNAs can regulate the phenotypic polarization of Mφs to M1 or M2 through various mechanisms; promote pro-inflammatory or anti-inflammatory effects; and participate in the pathogenesis of cancers, inflammatory diseases, infections, metabolic diseases, and autoimmune diseases. In addition, it is important to explore the regulatory mechanisms of lncRNAs on the dynamic transition between different Mφs phenotypes. Thus, the regulatory role of lncRNAs in the polarization of Mφs and their mechanism are discussed in this review.
Impacts of Light and Food Availability on Early Development of Cassiopea Medusae
Authors: Muffett Kaden McKenzie , Aulgur Joleen , Miglietta Maria Pia
Published: January 2022

The Cassiopea genus is an emergent focus for behavioral, ecological, and genetic research. Cassiopea ephyrae, a key intermediate in the life cycle of this benthic jellyfish, have been left out of much work on the genus. Here we investigate the Cassiopea xamachana ephyra response to six combinations of light and feeding regimes. We show that zero light condition results in fast bleaching of ephyrae and significant reductions in bell size and predation success. We also show that ephyrae starved in sub-compensation level light experienced only meager reductions in size over 42 days, and those starved in zero light were still largely recoverable at 28 days. Developmental trajectories on various metrics of Cassiopea xamachana ephyrae were significantly impacted by both light and feeding level in the first 42 days of life.