bluuebunny/crossref_metadata_2025 huggingface dataset:
A Guide to Measuring and Interpreting Omega-3 (n-3) Fatty Acid Status in Relation to Health
Authors: Gibson Robert , SImmonds Lucy , Liu Ge , Coates Penelope , Lam Khoa , Ranieri Enzo , Mas Emile , Makrides Maria
Published: April 2024

Dietary fats can play a role in life-long health outcomes. The role of polyunsaturated fatty acids (PUFA) in health and disease has been a keen focus of researchers for over 50 years. Recently the focus of this research has turned to the beneficial role of the omega-3 (n-3) PUFA on health outcomes including heart disease and the prevention of preterm birth. From the standpoint of clinical practice, there has been a call for reliable screening tests that can predict risk. Two tests, both involving the measurement of n-3 PUFA in blood or its fractions, have become prominent, namely, the ‘omega-3 index’ as a predictor of cardiovascular disease risk and the ‘total n-3’ pregnancy test as a predictor of risk of premature birth. We provide an overview for pathologists, clinicians and nutritionists of the methodology and terminology related to the n-3 biomarkers to aid their interpretation of proposed cut-point values for health risk.
Детермінанти інноваційного розвитку в контексті цифрової економіки та трансформації фінансового сектору
Authors: Кириленко С.В.
Published: April 2024

В представленій роботі зазначено, що інноваційний розвиток у контексті цифрової економіки та трансформації фінансового сектору залежить від численних детермінант, які формують умови для створення та впровадження новаторських технологій та підходів. Завдяки розвитку комунікацій та технологій зв’язку – стільникового, супутникового, широкосмугового та бездротових технологій, почався процес цифровізації суспільства. Якщо глобальна мережа Інтернет відкрила шлях для обміну інформації, то сучасні технології, що втілились у поширенні персональних засобів зв’язку – смартфонів та персональних комп’ютерів, змінили сам процес отримання, обміну та використання інформації. Вплив цифровізації та інформатизації суспільства на економічне зростання відбувався з одночасною трансформацією підходів до обробки даних, їх накопичення та змін в парадигмі торгівельних та економічних відносин. Для побудови стійкої цифрової економіки і досягнення економічного зростання необхідно виявити та проаналізувати тенденції цифровізації в різних сферах життя та виокремити потенційні можливості для подальшого розвитку. Метою статті є аналіз етапів розвитку глобалізаційних процесів та вплив на них цифровізації, визначення основних наслідків впровадження цифрових технологій в економіці, виробництві та інших сферах, а також аналіз тенденцій та перспектив для подальшого розвитку вітчизняної економіки та бізнесу в контексті впровадження принципів цифрової економіки та їх переваги. Автор аналізує тенденції розвитку глобалізаційних процесів в світовій економіці та те, яким чином впливає цифрова трансформація на міжнародний розвиток. В статті наведено основні етапи глобальних перетворень, викликаних цифровізацією, а також вплив цифрової трансформації на економіку. Розглянуто переваги впровадження принципів цифрової економіки та ризики, котрі викликані зміною економічної парадигми в контексті цифровізації всіх сфер нашого життя. Ці детермінанти взаємодіють та впливають на інноваційний розвиток у цифровому фінансовому секторі. Врахування цих факторів дозволяє створювати ефективні стратегії для успішної трансформації та впровадження цифрових інновацій в фінансову сферу.
Застосування «теорії змін» у стратегуванні розвитку громадських організацій
Authors: Христенко Л.М. , Чала П.В.
Published: April 2024

У дослідженні доведено, що у сучасному демократичному світі громадські організації як інституції громадянського суспільства є активними учасниками публічних процесів. Розвиток громадських організацій у довгостроковій (стратегічній) перспективі залежить від належного полі-спрямованого управління, коли мають враховуватися стратегічні цілі функціонування й розвитку як самої громадської організації, так й різних зовнішніх стратегічних акторів (гравців), дотичних до її діяльності (громадських спільнот, органів влади різних рівнів, представників благодійних інститутів, представників бізнесу як роботодавців та інвесторів, представників рекламних компаній, ЗМІ та ін.). Тож, пропонується у питаннях забезпечення довгострокового успіху своєї діяльності громадським організаціям звертатися до стратегування як процесу формування й впровадження стратегій для досягнення конкретних цілей або вирішення конкретних проблемних напрямків суспільного значення. Доведено, що стратегування є ключовим елементом управління розвитком, який визначає, як громадська організація буде виявляти суспільні запити з боку цільових груп населення, перетворювати ці запити на напрями своєї діяльності, розвивати й реалізовувати такі напрями шляхом ефективного й цільового використання залучених ресурсів.Виокремлено два етапи стратегування: перший етап ґрунтується на дослідженні, осмисленні й формулюванні суспільних потреб громадян у формі неотримання або недоотримання певних суспільно-корисних цінностей; другий етап передбачає генерування альтернатив вирішення проблемних питань, що виникли у суспільстві, з урахуванням інтересів громадської спільноти та самої громадської організації. Запропоновано у реалізації другого етапу стратегування розвитку застосовувати «теорію змін» як інструменту для формування спеціальної стратегії у межах основної діяльності, яка полягає у задоволенні певної соціально-корисної потреби громадян. Апробація застосування «теорії змін» у стратегуванні розвитку громадських організацій здійснена на прикладі громадської організації просвітницького типу «Платформа розвитку «СМР». Виявлені зміни та їхні результати, які знаходяться у полі діяльності ГО «Платформа розвитку «СМР» та запропонований спрощений приклад «карти результатів» у процесі впровадження стратегії розвитку ГО «Платформа розвитку «СМР» шляхом активізації напряму вирішення суспільної проблеми «захист прав людини у бізнесі».
СМЕРТНА КАРА В ІСТОРІЇ УКРАЇНСЬКОГО КРИМІНАЛЬНОГО ПРАВА ХV–ХVІ СТСТ.
Authors: Подорога Л. В.
Published: April 2024

У статті досліджено зміст, основні риси смертної кари в історії українського кримінального права ХV–ХVІ стст. Доведено, що причинами уведення та поширення в нормативних джерелах смертної кари були розвиток державотворчих та господарських процесів, васальних відносин, формування розгалуженої судової системи, особливості політичного та соціального становища в державі шляхти, вплив іноземного права, необхідність реалізації залякування як мети покарання. З’ясовано, що смертна кара у ХV – на початку ХVІ ст. не мала істотного значення, але у кожній новій редакції Литовського Статуту її вага збільшується, свідченням чого є збільшення кількості норм щодо призначення смертної кари, зростання кількості норм, в яких говориться про призначення видів простої та кваліфікованої смертної кари, урізноманітнення термінології, яка відображала різні види страти. Визначено, що проста смертна кара передбачалась за вчинення тяжких, а кваліфікована – особливо тяжких державних, військових, посадових злочинів, злочинів проти правосуддя, особи чи власності, релігії та моралі. Аналіз норм правових пам’яток ХV–ХVІ стст. дав можливість виокремити загальні підстави призначення смертної кари (спричинення істотної шкоди державі, неповага до монарха, порушення клятви, умисність, значні майнові збитки особі, каліцтво, ганебність учинку). До специфічних підстав призначення кваліфікованої смертної кари можна віднести особливу небезпеку діяння, заподіяння великої шкоди державі, мотив, підступність та ганебність діяння, скоєння неприпустимого гріха, можливість масового заподіяння смерті, родинні чи сімейні зв’язки, відносини між паном та слугою. Встановлено, що особливе місце серед підстав займав соціальний стан вбитого та злочинця: страта передбачалась за принципом права-привілею. Виявлено, що вбивство шляхтичем простолюдина мало пройти складну процесуальну форму доведення вини і каралось простою смертною карою або каліцтвом; якщо ж було убито шляхтича простолюдином, то останній безумовно підлягав кваліфікованій смертній карі.
Clinical manifestations and seasonal occurrence of patients with dengue hospitalized at Dhaka city of Bangladesh in 2021
Authors: Barua Priyanka , Mahjuba Sayeda , Khan Afsana Alamgir , Biswas Md Rasel , Rahman Md Khalilur , Musa Sharmin
Published: April 2024

For the past few years, the intensity of dengue in Bangladesh has been rising. The current study was done among 533 dengue patients hospitalized in 2021 in Dhaka to observe the different aspects of clinical manifestations and seasonal occurrence of dengue. Due to COVID-19 restriction, hospital entry and face-to-face interview of the patients was not possible. Hence, contact numbers of the hospitalized dengue patients were collected from Directorate General of Health Services (DGHS) and patients were interviewed over the phone. Out of 533 patients, majority were from Dhaka south city corporation (DSCC) (53.7%), had a monthly household income of 30001≥ BDT (67.4%), and lived in small sized families (76.9%). High fever (p=0.013), headache (p<0.001), body pain (p<0.001), vomiting/nausea (p=0.0085), skin rash (p=0.033), eye lesion/red eyes (p=0.0011), pleural effusion (p=0.0404), weakness (p=0.017) and gum bleeding (p=0.014)- were significantly associated with age groups whereas vomiting/nausea (p=0.048), skin rash (p=0.002) and eye lesion/red eyes (p=0.032) were significantly associated with gender. 86.7% suffered from thrombocytopenia (<150000 per microliter blood), while 27% were in serious condition with lowest platelet count ≤ 20000 per microliter blood. 3.6% patients were admitted to ICU and 1.7% died of dengue. Death due to dengue was significantly associated with age groups (p <0.05) and majority among them were children (≤ 10 years). Family members of 44.6% patients were also affected with dengue and majority of the patients belonged to small sized families. Dengue occurrence had significant association with season where majority of the patients were from monsoon season (65.29%) followed by post-monsoon (33.21%) season. Dengue manifests a wide spectrum of symptoms as shown by the study, so now it is necessary to identify the changes in pattern of the clinical manifestations, and effective disease management to lessen the severity of the outbreak.
Dhaka Univ. J. Biol. Sci. 33(1): 33-46, 2024 (January)
The relationship between childhood maltreatment and suicidal ideation among adults
Authors: Zakir Tanzina , Haque Mahjabeen
Published: April 2024

Childhood maltreatment is the potential background under the umbrella of adverse childhood experience (ACE). The history of childhood trauma as well as child abuse can be affected lifelong through their adulthood stages. In addition, suicide is the most global issue among young generation. The present focused study determined to get the essence of the direction into the relationship between childhood maltreatment and suicidal ideation among adults in Bangladesh context. The cross sectional survey design was adopted for data collection purpose among 160 adults having age ranges between 18 to 40 years. Correlation analysis findings recommended that there is a strong association between childhood maltreatment and suicidal ideation (Spearman’s rank order correlation coefficient, r = 0.80, p < 0.01) and (Kendall’s tau-b rank order correlation coefficient, r = 0.62, p< 0.01). Furthermore, controlling with another aspect of chronological age, socio-economic status, profession and mental health service also indicating a moderate strong relationship between childhood maltreatment and suicidal ideation (Partial correlation coefficient, r (160) = 0.62, p < 0.01), (Partial correlation coefficient, r (160) = 0.63, p < 0.01), (Partial correlation coefficient, r (160) = 0.60, p < 0.01) and (Partial correlation coefficient, r (160) = 0.68, p < 0.01). The present research is the resource for mental health practitioner, academia, researcher, professional child psychologist, scholar, social worker etc who are willing to influence and contribute in mental health areas.
Dhaka Univ. J. Biol. Sci. 33(1): 47-55, 2024 (January)
Effect of COVID-19 pandemic on gender based violence: a study on TMSS microcredit members
Authors: Sultana Most Aeysha , Rahman Arifa
Published: April 2024

The present study was aimed at investigating if the COVID-19 outbreak had an impact on gender-based violence (GBV) among TMSS microcredit users. The study was designed to gather data using both quantitative (individual interviews) and qualitative (Focus Group Discussion) method. One hundred and eighty-five married women of Bogura district made up the sample. The sample included 159 microcredit members and 26 non-members. Majority of the participants experienced financial hardships during the COVID-19 epidemic, according to quantitative and qualitative data. Quantitative data showed that a significant portion of microcredit participants (56%) experienced physical, mental, or both types of violence from their husbands during the lockdown. However, the TMSS Microcredit members had greater exposure to GBV than non-members, according to qualitative findings. The same factors—such as income loss, staying at home constantly, and concern about providing for family needs—were highlighted by both microcredit members and non-members as probable causes for the rise in violence during lockdown. But microcredit members mentioned that the lack of microcredit loans and the pressure to make loan payments also resulted in violence against women during lockdown. Quantitative data also indicated that women who experienced violence from their husbands had trouble accessing medical care and law enforcement support. The present study recommended that during emergency situation the microcredit providers should take different policies to help people cope with their financial crisis and government and non-government organizations should take safeguards to prevent gender based violence.
Dhaka Univ. J. Biol. Sci. 33(1): 57-65, 2024 (January)
Induction of mutation in Neurospora Crassa using neem (Azadirachta Indica A. Juss) leaf extract
Authors: Khatun Rikta , Saha Sanchita , Islam Mohammad Nurul , Amin G M Al
Published: April 2024

Filamentous fungus has been used as a significant source of biotechnological applications. Neurospora crassa, a type of red bread mold, has been well recognized as a model system in fundamental scientific investigations. It can be effectively utilized as a valuable resource for molecular tools, and many mutations are available. Furthermore, N. crassa exhibits rapid growth and has no harmful properties. These characteristics indicate a significant, although unexplored, capacity of this fungus for use in biotechnological endeavors. The present investigation aimed to induce morphological changes in the N. crassa wild type by employing leaf extracts derived from Azadirachta indica A. Juss. To determine the mutagenic and growth-inhibitory effects of A. indica leaves, morphological mutants were identified and individually examined. Six morphological mutants such as albino (al), cauliflower (clf), conidial band (co.band), ropy light (ro.lig), dirty (dir), and ropy (ro) were obtained from the conidia of the wild-type N. crassa Ema (5297) strain, treated with A. indica A. Juss. leaf extracts. These mutants were compared to the wild-type, natural form of the organism in terms of their morphology, radial growth, and reproduction ability. Apparent variations were observed when a comparative study of Ema and the selected morphological mutants was undertaken. Linkage among the selected mutants in their specific linkage group was determined. Ropy, dirty, and albino were all linked to leu-3 (linkage group I), conidial-band and ropy light to trp-1 (linkage group III), and cauliflower to trp-4 (linkage group VII). Complementation was not observed in similar morphological N. crassa mutants.
Dhaka Univ. J. Biol. Sci. 33(1): 79-98, 2024 (January)
A análise de fatores para o desenvolvimento da obesidade infantil como uma medida para a sua prevenção
Authors: Fernandes Lorena de Medeiros Paiva , Sampaio Maria Nayara Ferreira , Lucena Bianca Araújo Tavares , Lucena Lara Beatriz Gomes de , Lucena Thaynar Araújo Tavares , Donha Nádilla Andrine dos Santos , Pimentel Luma de Oliveira , Lourenço Izabely Moraes , Campideli Larissa Maria , Araújo Rafaela Silva , Félix Yan Rahyoni Duarte Viana , Feitosa Ankilma do Nascimento Andrade
Published: April 2024

Objetivo: Apresentar as principais causas de desenvolvimento da obesidade infantil e formas de atenuar o crescimento dessa doença. Método: Foi realizada uma revisão integrativa da literatura, no mês de março de 2024, utilizando os descritores “Indicators of Quality of Life”, “Pediatric Obesity” e “Risk”, através das bases de dados PubMed e BVS. Resultados e Discussões: Algumas condições estão intrinsecamente relacionadas ao desenvolvimento de obesidade infantil, como fatores comportamentais, ambientais, biológicos e genéticos. Dentre esses, a prática de hábitos alimentares inadequados foi vista como o fator mais influente para a ocorrência dessa doença. Além disso, um ensaio chamado ToyBox mostrou que hábitos sedentários, como assistir televisão e usar jogos eletrônicos, incentivam o consumo de alimentos de alto teor calórico. Outros, observaram que houve um declínio dos níveis de condicionamento físico em crianças e adolescentes em todo o mundo, e que tal condição é diretamente proporcional ao aumento do risco metabólico nessa faixa etária. Por fim, relacionando as dimensões do sono e o risco de sobrepeso ou obesidade infantil, evidenciou que hábitos de sono ruins a partir de 1 ano de idade aumentam o risco de desenvolvimento de obesidade a longo prazo. Considerações Finais: Portanto, a obesidade infantil é uma doença que pode acarretar inúmeros problemas crônicos e graves não só durante a infância, como durante a vida adulta. O desenvolvimento dessa condição está relacionado a fatores que podem ser modificados.
Development of pilot plants for engineering education
Authors: Castro Laura Luisa Coelho , Costa Taís Resende , Parreira Carla Cristina Araújo , Gonçalves Lindomar Matias , Oliveira Idalmo Montenegro de , Cardoso Marcelo , Santos Luiz Carlos
Published: April 2024

The rapid changes in social interactions and the easy access to information brought by technological advances require that professors rethink and rebuild teaching to maintain its quality. Active methodologies have been used to ensure the development of essential skills in professionals to deal with the current challenges and demands of the job market. This study presents the use of active project-based methodologies with undergraduate and postgraduate engineering students at the Federal University of Minas Gerais. This study aims to report on the implementation of a pilot plant for the causticizing stage of the pulp and paper Kraft Process and the development of two prototypes of industrial sludge drying equipment using solar energy and to evaluate the impact of the activities on the professional training of the people involved and the development of skills and competencies expected of engineering professionals according to the National Curriculum Guidelines, such as the ability to work in teams. The students could apply their technical knowledge in real situations in an interdisciplinary and multidisciplinary collaborative environment that encourages the resolution of complex engineering problems innovatively, with a holistic and humanistic vision that also considers social and sustainable aspects. They also demonstrated increased motivation and experienced the connection between industry and academia, which is essential to demonstrate the applicability of the techniques learned during the courses.
O acesso à educação: Os desafios do transporte escolar na zona rural do município de Apiacá/ES
Authors: Mendonsa Robson Alves , Nascimento Luana Aparecida Lima do , Silva Carla Bastos Leite da
Published: April 2024

O estudo trata do transporte escolar como meio de acesso e permanência a educação na zona rural. O objetivo foi analisar a qualidade do transporte escolar provido pelas entidades públicas de Apiacá/ES e sua eficácia em atender às necessidades da comunidade local. Trata-se de estudo descritivo, com abordagem qualitativa, que utilizou de entrevistas com seis participantes, o levantamento documental, além da observação em uma unidade escolar na zona rural do município. Os resultados evidenciam que as condições das estradas não asfaltadas na região representam um desafio significativo que impacta a qualidade do transporte escolar em Apiacá/ES, especialmente na Comunidade de Batatal. Desafios logísticos, relacionados à gestão eficiente de recursos em um município de dimensões reduzidas, influenciam a pontualidade e as taxas de frequência escolar. Diante disso, os recursos do PNATE tornam-se essenciais no financiamento e manutenção do transporte escolar em zonas rurais de comunidades pequenas.
Focos da aprendizagem: Sua validação por meio de um questionário
Authors: Rudnik Luciano , Passos Marinez Meneghello , Arruda Sergio de Mello , Ortiz Adriano Jose , Passos Angela Meneghello , Oliveira Katya Luciane de
Published: April 2024

O objetivo deste artigo é trazer os resultados de um processo de validação de um questionário, destinado à evidenciação de indícios da presença dos Focos da Aprendizagem nas respostas fornecidas por participantes de eventos científicos. A elaboração do questionário começou com a realização de um levantamento sobre as produções divulgadas a respeito dos Focos da Aprendizagem, o que nos proporcionou um período que vai de 2012, primeira publicação identificada, a 2021, quando encerramos as buscas. Para a interpretação dos vinte e oito artigos selecionados, fizemos uso dos procedimentos metodológicos indicados pela Análise de Conteúdo, procurando pelas expressões utilizadas para caracterizar os Focos. Tais expressões foram organizadas em categorias emergentes, representadas por palavras ou frases, que vieram a compor, posteriormente, cinco questionários distintos, um para cada Foco: Interesse, Conhecimento, Reflexão, Comunidade e Identidade. A validação do questionário foi realizada por meio da Análise Fatorial Exploratória, mediante as respostas dadas por 188 participantes, resultando em cinco fatores, que demonstraram cargas fatoriais elevadas associadas aos itens correspondentes, alinhando-se com a teoria dos respectivos Focos de Aprendizagem. Os resultados indicam que o questionário apresenta evidências exploratórias de validade e uma estrutura interna adequada para avaliar a presença dos Focos da Aprendizagem. Cada Foco pode ser descrito por um conjunto específico de indicadores, fundamentados em produções científicas relacionadas ao tema. Consequentemente, o instrumento desenvolvido oferece uma alternativa viável à entrevista semiestruturada para avaliar a presença dos Focos em eventos científicos.
The potential of artificial intelligence in early diagnosis and personalized treatment: Advances and challenges in modern medicine
Authors: Galvão Amanda Albuquerque Cursino B. , Soares Romerio Alves , Ramos Davi Silva , Oliveira Ane Caroline Rodrigues de , Leite Lucélia Vital , Cavalcante George da Silva Tenório , Moura Felipe Alves Celestino de , Cavalcanti Ana Júlia de Oliveira , Damaso Cristiane Ramos Santos , Correia Lucilene Mororó Lima , Asevedo Marcelo Pininga Pessoa de , Silva Carlos André Souto , Araújo Elison Lins
Published: April 2024

Carrying out this study is justified by its academic, scientific and social relevance, based on presenting technological advances involving artificial intelligence in healthcare. Therefore, the objective of this research focuses on highlighting the applications and benefits of Artificial Intelligence in Medicine. This study was carried out through an integrative literature review, with an exploratory approach, whose institute was limited to investigating, through already published articles, relevant information that answered the guiding question. Thus, data collection took place in scientific bases: SCIELO and LILACS. One of the main advantages of using AI in early diagnosis is the ability to process large volumes of data quickly and accurately, identifying patterns and signals that may be imperceptible to human healthcare professionals. This makes it possible to detect serious medical conditions early, such as cancer and heart disease, when treatment is most effective and the chances of recovery are greatest. Furthermore, AI can significantly contribute to personalized treatment, adapting therapeutic approaches based on the individual characteristics of each patient. By analyzing genetic data, medical history, and response to previous treatments, AI algorithms can help doctors develop treatment plans that are more effective and have fewer side effects.
AIDS em adultos na capital mineira: Um projeto de intervenção
Authors: Guimarães Gustavo Macanhan Soares , Almeida Filho Claiton Luiz de , Abreu Lucas Rodrigues de , Melo Sthephany Yamaguchi de , Oliveira Stefan Vilges de
Published: April 2024

Introdução: A AIDS continua sendo um dos principais problemas para os sistemas de saúde. No Brasil, mesmo com a presença de um programa que revolucionou a melhoria da expectativa de vida desses pacientes, doenças oportunistas ainda causam muitas fatalidades. O objetivo deste artigo é estudar e propor intervenções para promover a prevenção da infecção por HIV e da evolução para AIDS. Métodos:  Estudo epidemiológico quantitativo descritivo dos casos confirmados de AIDS no município de Belo Horizonte/MG, no período de 2013 a 2023, utilizando dados secundários. Realizou-se, também, revisão sistemática sobre intervenções para prevenção da infecção por HIV e da evolução para um quadro de AIDS publicadas entre 2013 a 2023 nas bases de dados SciELO e Pubmed. Resultados: Foram confirmados 15.170 casos de AIDS, apresentando maior queda de diagnósticos de 2022 a 2023, de cerca de 36%. A maioria (39,7%) dos casos foi descrita em pacientes com relações homossexuais, 36,2% na faixa etária dos 25 aos 34 anos e 76,4% vivendo em área urbana. Ainda, 84,7% se encontram vivos, 935 morreram de AIDS e 95 de outras causas. As principais intervenções identificadas por meio da revisão de literatura estão pautadas na educação em saúde, rastreio e seguimento. Conclusão: Este estudo permite entender que a luta contra essa doença ainda precisa expandir as ações de prevenção e intervenção na comunidade para reduzir a sua transmissão.
PETROSELINUM CRISPUM (MILL.) FUSS (PARSLEY), A FOOD AND MEDICINALLY IMPORTANT PLANT: A REVIEW OF RECENT STUDIES BETWEEN 2013-2023
Authors: Subaş Tuğba , Özgen Ufuk , Gökkaya İçim , Renda Gülin
Published: April 2024

Objective: Petroselinum crispum (Mill.) Fuss is a bright green biennial medicinal and aromatic herb that grows almost all over the world. Today, it is one of the most commonly used culinary herbs. In addition to its use as food, it has been shown to possess broad pharmacological activities in several in vivo and in vitro studies. This study aimed to comprehensively summarize the current studies on the traditional use, phytochemical composition, pharmacological activities, clinical studies, toxicity, and drug interactions of parsley.
Result and Discussion: According to the literature data, parsley is used as a diuretic, carminative, emmenagogue and for the prevention and treatment of kidney stone formation, the treatment of conditions such as urinary tract infections and stomach disorders. Its phytochemical composition consists of flavonoids, coumarins, phenolic compounds, organic acids, carotenoids, vitamins, minerals, fixed oil, essential oil, and other compounds. Studies on P. crispum have shown that it has a wide range of pharmacological activities, including antioxidant, antibacterial, antifungal, antidiabetic, antihypertensive, antiplatelet, analgesic, antiinflammatory, antihepatotoxic, antinephrotoxic, anticancer, antiurolithiatic, wound healing, antiobesity, estrogenic and neuroprotective effects. This review comprehensively summarizes the scientific data of the last ten years (2013-2023) on P. crispum.
Navigating the Ending of Animal Lives in Veterinary Practice
Authors:   , Deelen Ellen
Published: April 2024

What can reasonably be expected of veterinarians in the decision-making process
on the ending of an animal’s life? While the answer may be evident in some cases,
research shows that certain end-of-life situations puzzle veterinarians. Navigating
these perceived complexities is known to reduce veterinarians’ sense of professional
accomplishment and overall well-being. Considering the impact of these situations
on veterinarians, there is a need to support them. Effective support requires an in-depth
understanding of the complexities that veterinarians experience in end-of-life
situations.
In this thesis, the foundation of this understanding is established through an analysis
of the concept of euthanasia of animals, illustrating the different perspectives of
veterinarians on the ending of animal lives. To achieve an understanding of the
perspectives and experiences of veterinarians in complex end-of-life situations,
interviews were conducted with veterinarians working in the Netherlands. Based
on these interviews, a duality in veterinarians’ role perception and perceived
responsibilities was discovered, i.e. some roles and responsibilities are shared among
a group of veterinarians, whereas others are perceived by individuals. Moreover,
different perspectives on the interplay of considerations in end-of-life situations were
identified. Last, the interviews revealed that, as part of their three-step decision-making
process, veterinarians contemplate various strategies.
These key findings provide insight into a) the complexity of end-of-life situations
that veterinarians experience and b) veterinarians’ approach to professional
responsibility in navigating end-of-life situations. Based on these insights, directions
for supporting veterinarians can be found in the educational program, the national
code of professional conduct, and the applicable legal framework. These support
options aim at positioning veterinarians so that they can work their way towards
the right balance between autonomy, consistency, trust and the dynamics of end-of-
life situations.
From atom to edge
Authors:   , Moes Jesper René
Published: April 2024

In chapter 3 the energy states of Bismuth Selenide (Bi2Se3) nanoplatelets were investigated in the STM. The nanoplatelets were synthesized in the laboratory in such a way that they are only a few nanometres in thickness. It was shown that the states at the top and the bottom of the material cancel each other out when the platelets are thin enough. Using the location specific techniques of the STM, it was shown that only a single state remains at the edge of the platelet, which could be visualized as a bright ring around the entire platelet as shown in figure 7.1b. Two different theoretical models were then used to model the electronic structure of the platelets and explain the experimental findings.
The robustness of these edge states in Bi2Se3 nanoplatelets against disorder, an applied magnetic field, and magnetic adsorbents was investigated in chapter 4. By looking at nanoplatelets with defects and structural irregularities it was shown that the edge state is very robust against disorder. Moreover, even a 5 Tesla magnetic field doesn’t break the state. However, when Mn atoms are deposited on the platelets, the state can be broken.
Chapter 5 describes the creation of quantum corrals by manually positioning Carbon Monoxide (CO) molecules on a copper surface. When placed in a circle or a square these electron-repelling molecules confine the electrons of the copper surface. As a result, an artificial atom is created, a square artificial atom can be seen in figure 7.1c. Such artificial atoms are then subjected to a magnetic field, and it is investigated in how far this affects the electronic states. Theoretically it is shown that there are two effects that split the energy states: the Zeeman effect and the Lorentz force. Experimentally it was impossible to replicate these results
The last project is described in chapter 6 of this thesis and focusses on dopant atoms in a semiconductor, Gallium Arsenide (GaAs). It is shown how the STM can be used to determine the electronic properties of single dopants. Moreover, we investigated to what extent such dopants can be used to build artificial structures (like the ones in chapter 5) and how the height of the tip can be used to research the effect of a magnetic field on the tunnelling probability through the GaAs surface. Especially the last part of the research shows an unexpected result with the STM tip behaving differently depending on the direction of the magnetic field ramps between -0.5T and 0.5T, as shown in figure 7.1d. This difference couldn’t be explained with the measurements in this work but shows how there will always remain scientific questions to be answered.
Principles of Creation of a Genetic Engineering Construction for Obtaining Humanized Transgenic Mice with HLA-C*07:02:01:01, as a Promote of Innovative Transgenic and Knockout Biomodels
Authors: Karkischenko N. N. , Lazarev V. N. , Manuvera V. A. , Bobrovsky P. A. , Petrova N. V. , Koloskova E. M. , Glotova E. S.
Published: April 2024

Genetic differences in different populations influence the mechanism and efficacy of drugs. Biomodels that take into account the peculiarities of genetic polymorphism in different individuals allow to more fully investigate the molecular-genetic mechanisms of action of pharmacological agents, including immunobiological ones. Recombinant DNA encoding a hybrid MHC class I protein containing human ß2-microglobulin fused with antigen-presenting domains (α1 and α2 domains) of the HLA-C*07:02:01:01 molecule and α3 domain of the mouse H2-complex was created. The purified linearized DNA fragment containing the target construct flanked by regulatory fragments ensuring its stable transcription was used to obtain a new line of humanized transgenic mice. The principles of designing humanized transgenic mice by encoding a chimeric MHC class I protein containing antigen-presenting domains HLA-C*07:02:01:01 are similar to those for obtaining mice of the HLA-А*02:01:01 and HLA-B*18:01:01:02 humanized transgenic lines. These transgenic lines of laboratory mice are independent biomodels, and also be used as baselines for obtaining corresponding transgenic and knockout lines.
Pengembangan Media Pembelajaran Komikita Berbasis E-Komik Materi Hak dan Kewajiban Pada Kelas V
Authors: Magfiroh Lailatul , Asmarani Ratih , Dwinata Anggara
Published: April 2024

Pengembangan media komikita berbasis E-Komik pada pembelajaran hak dan kewajiban di rumah maupun di sekolah guna membentuk karakter peserta didik kelas V Sekolah Dasar. Sebab di sekolah banyak dijumpai peserta didik yang belum faham akan hak dan kewajibannya. Serta pengembangan komikita mengenalkan teknologi pada peserta didik karena belum optimal dalam penggunaan teknologi dalam pembelajaran. Jenis penelitian yang diimplemetasikan peneliti menerapkan jenis model ADDIE yang dikembangkan oleh Rahmadhany, mempunyai lima proses yang sistematis yakni analisis, desain, pengembangan, implementasi dan evaluasi. Subjek penelitian yaitu siswa kelas V-A SDN Kepanjen 2 Jombang tahun ajaran 2022/2023. Instrumen memperoleh data menggunakan catatan lapangan, lembar validasi media, angket respon siswa, tes dan dokumentasi. Teknik pengumpulan data untuk mengukur kevalitad media menggunakan lembar angket validasi materi maupun media yang dinilai oleh para ahli validator. Serta respon guru dan peserta didik setelah menggunakan media pembelajaran E-Komik. Serta dalam mengukur pemahaman materi menggunakan tes. Pada kualitas media pembelajaran E-komik memperoleh nilai rata-rata 96,25% dengan kriteria sangat valid. Dalam kevalidan materi memperoleh nilai 87,5% dengan kriteria sangat valid. Serta terdapat repon peserta didik dan guru dengan rata-rata 88,78% dengan kriteria sangat valid. Jadi untuk nilai rekapitulasi Nilai kualitas Media Pembelajaran E-Komik yakni 89,03% dengan kriteria sangat valid. Dalam impelentasi peneliti medapatkan hasli respon siswa dan guru kelas. Pada tahap validasi media memperoleh rata- rata 91,87% dengan kriteria sangat valid. Peneliti dalam implementasi membagikan lembar tes dan mendapatkan nilai rata-rata 89,48% dengan kriteria sangat baik. Maka media komikita layak dan cocok untuk di Implementasikan.
Development of Educandy Game-Based Interactive Learning Media in the Merdeka Curriculum for Elementary School
Authors: Larasati Anisa Nurlaila , Asmarani Ratih , Susilo Claudya Zahrani
Published: April 2024

This development research was conducted with the aim of evaluating the feasibility of the Educandy game-based learning media implemented in the Merdeka curriculum, with a focus on supporting students in developing attitudes as Pancasila learners, including religious, diversity, cooperation, independence, critical thinking, and creativity. This study was conducted due to the difference in students' interests between games and the learning process.The researcher developed the Educandy game-based learning media in the form of a web-based application, aiming to serve as an interactive learning media to enhance the learning enthusiasm of fourth-grade students at SDN Kepanjen 1, Jombang. The main objective of developing this learning media was to produce appropriate and suitable learning media according to the learning needs.The development process of the Educandy game-based learning media adopted the Research and Development (R&D) method by applying the ADDIE model. The ADDIE model consists of five stages: Analysis, Design, Development, Implementation, and Evaluation. The results of media validation, material validation, and questionnaires given to the students indicated that the Educandy game-based interactive learning media achieved a percentage of 91.5% with a highly valid category and can be used without revisions. Furthermore, the implementation results of the media among students and teachers showed an average percentage of 93% with a highly interesting category.
Pengembangan Media Pembelajaran Powerpoint Quizizz Untuk Meningkatkan Hasil Belajar Siswa Kelas III SD
Authors: Lestari Fivi Setya , Asmarani Ratih
Published: April 2024

Dunia pendidikan membutuhkan inovasi serta kreativitas yang dapat membantu meningkatkan kualitas pendidikan. Sebuah Upaya yang dapat digunakan untuk untuk rneningkatkan kualitas pendidikan yakni dengan cara rneningkatkan hasil belajar siswa. Hasil belajar siswa yang kurang memuaskan terutama materi PPKn menjadi permasalahan yang perlu dicari solusinya. Untuk rneningkatkan hasil belajar siswa seorang pendidik bisa memakai rnedia pernbelajaran yang rnenarik. Tujuan dari penelitian ini yakni untuk rneningkatkan hasil belajar siswa pada pernbelajaran PPKn materi menerima hak dan kewajiban melalui pengembangan media PowerPoint Quizizz. Penelitian ini rnenggunakan rnetode penelitian R&D dan rnodel pengernbangan ADDIE yakni Analisis, Desain, Pengernbangan, Irnplementasi, iEvaluasi. Penilaian kelayakan media PowerPoint Quizizz dilakukan oleh validator rnateri dan rnedia, serta siswa dan pendidik dengan tigai kali uji coba yakni skala kecil, berkelompok dan besar, dani keefektifan media PowerPoint Quizizz dilakukan oleh siswa kelas III SD dengan dilakukann uji pre-test dan post-tes. Hasil penelitian menunjukan bahwa proses pengembangan telah sesuai dengan langkah pada model ADDIE. Hasil kelayakan diperoleh dari penilaian validator 84,7% dengan kualifikasi valid, dan uji coba skala kecil 91,4% dengan kualifikasi sangat layak , berkelompok 86% dengan kualifikasi sangat layak, dan skala besar 99,1% dengan kualifikasi sangat layak, serta hasil keefektifan yang didapatkan dari penilaian pre-test 77% dengan kualifikasi efektif dan pos-test 88,5% dengan kualifikasi sangat efektif. Dapat di tarik kesimpulan berdasarkan uji coba pengembangan media bahwa Powerpoint Quizizz menunjukkankan hasil yang signifikan. Dengan untuk rneningkatkan hasil belajar siswa kelas III SD rnedia pernbelajaran PowerPoint Quizizz sangat layak dan sangat efektif digunakan.
Clinical and genetic characteristics of Chinese patients with Shwachman Diamond syndrome: a literature review of Chinese publication
Authors: Wang Lijun , Jin Youpeng , Chen Yuan , Zhao Ping , Shang Xiaohong , Liu Haiyan , Sun Lifeng
Published: April 2024

Shwachman Diamond syndrome (SDS) is a rare autosomal recessive genetic disorder and due to its complex and varied clinical manifestations, diagnosis is often delayed. The purpose of this study was to investigate the clinical manifestations and genetic characteristics of SDS in Chinese patients, in order to increase pediatricians’ awareness of SDS and to allow early diagnosis. We conducted a search to identify patients presenting SBDS gene pathogenic variant in two Chinese academic databases. We analyzed and summarized the epidemiology, clinical features, gene pathogenic variants, and key points in the diagnosis and treatment of SDS. We reviewed the clinical data of 39 children with SDS from previously published articles. The interval from the onset of the first symptoms to diagnosis was very long for most of our patients. The age of presentation ranged from 1 day to 10 years (median: 3 months). However, the age of diagnosis was significantly delayed, ranging from 1 month to 14 years (median: 14 months). Hematological abnormalities were the most common presentation, 89.7% (35/39) at the beginning and 94.9% (37/39) at diagnosis of SDS. Diarrhea was the second most common clinical abnormality at the time of diagnosis. 59% (23/39) of patients had a typical history of persistent chronic diarrhea. Furthermore, hepatic enlargement or elevation of transaminase occurred in 15 cases (38.5%). 56.4% patients (22/39) had a short stature, and 17.9% (7/39) patients showed developmental delay. Additionally, twenty patients had compound heterozygous pathogenic variants of c.258 + 2T > C and c.183_ 184TA > CT. Children with SDS in China had high incidence rates of chronic diarrhea, cytopenia, short stature, and liver damage. Furthermore, SBDS c.258 + 2T > C and c.183_ 184TA > CT were the most common pathogenic variants in patients with SDS. The diagnosis of SDS can be delayed if the clinical phenotype is not recognized by the health care provider.
Co-design personal sleep health technology for and with university students
Authors: Liang Zilu , Melcer Edward , Khotchasing Kingkarn , Hoang Nhung Huyen
Published: April 2024

University students often experience sleep disturbances and disorders. Personal digital technologies present a great opportunity for sleep health promotion targeting this population. However, studies that engage university students in designing and implementing digital sleep health technologies are scarce. This study sought to understand how we could build digital sleep health technologies that meet the needs of university students through a co-design process. We conducted three co-design workshops with 51 university students to identify design opportunities and to generate features for sleep health apps through workshop activities. The generated ideas were organized using the stage-based model of self-tracking so that our findings could be well-situated within the context of personal health informatics. Our findings contribute new design opportunities for sleep health technologies targeting university students along the dimensions of sleep environment optimization, online community, gamification, generative AI, materializing sleep with learning, and personalization.
The perceived coolness of using virtual reality technology in blended learning performance can improve learning motivation and learning satisfaction
Authors: Liu Xiaojun , Zhang Hui , Liu Liang
Published: April 2024

This study verifies the practical use of virtual reality (VR) technology in real-world educational settings. The evidence indicates that the unique encounter provided by technology can assist university scholars in mastering educational assignments with high motivation and satisfaction toward the innovative learning system. This study analyzes 82 college students who used VR technology in the classroom for 6 weeks. The collected data were further analyzed using SPSS24.0 and SMARTPLS 3 analysis software. The study found the use of VR technology in education led to high levels of satisfaction and motivation to learn. As a result, college students’ learning performance was improved. The research also found that learning motivation and satisfaction played a partial role in mediating the correlation between perceived coolness and blended learning performance. This finding highlights the importance of the blended learning task arrangement, which was further verified through actual learning tasks.
A population-based prospective study on obesity-related non-communicable diseases in northern Iran: rationale, study design, and baseline analysis
Authors: Motamed Nima , Zamani Farhad , Maadi Mansooreh , Ajdarkosh Hossein , Roozafzai Farzin , Keyvani Hossein , Poustchi Hossein , Shakeri Ramin , Ashrafi G. Hossein , Perumal Dhayaneethie , Rabiee Behnam , Moradi-Lakeh Maziar , Khoonsari Mahmoodreza , Kheyri Zahedin , Sohrabi Masoud Reza , Doustmohammadian Azam , Amirkalali Bahareh , Safarnezhad Tameshkel Fahimeh , Gholizadeh Esmaeel , Hosseini Seyed Hamzeh , Karbalaie Niya Mohammad Hadi
Published: April 2024

Background

Iran is facing an epidemiological transition with the increasing burden of non-communicable diseases, such as obesity-related disorders and cardiovascular diseases (CVDs). We conducted a population-based prospective study to assess the prevalence and incidence rates of CVDs and obesity-related metabolic disorders and to evaluate the predictive ability of various CVD risk assessment tools in an Iranian population.

Method

We enrolled 5,799 participants in Amol, a city in northern Iran, in 2009–2010 and carried out the first repeated measurement (RM) after seven years (2016–2017). For all participants, demographic, anthropometric, laboratory, hepatobiliary imaging, and electrocardiography data have been collected in the enrollment and the RM. After enrollment, all participants have been and will be followed up annually for 20 years, both actively and passively.

Results

We adopted a multidisciplinary approach to overcome barriers to participation and achieved a 7-year follow-up success rate of 93.0% with an active follow-up of 5,394 participants aged 18–90 years. In the RM, about 64.0% of men and 81.2% of women were obese or overweight. In 2017, about 16.2% and 5.2% of men had moderate or severe non-alcoholic fatty liver disease, while women had a significantly higher prevalence of metabolic syndrome (35.9%), and type 2 diabetes mellitus (20.9%) than men. Of 160 deceased participants, 69 cases (43.1%) died due to CVDs over seven years.

Conclusion

The most prevalent obesity-related chronic disease in the study was metabolic syndrome. Across the enrollment and RM phases, women exhibited a higher prevalence of obesity-related metabolic disorders. Focusing on obesity-related metabolic disorders in a population not represented previously and a multidisciplinary approach for enrolling and following up were the strengths of this study. The study outcomes offer an evidence base for future research and inform policies regarding non-communicable diseases in northern Iran.