bluuebunny/crossref_metadata_2025 huggingface dataset:
Çuci Han’ın Tespit Edilen Evlilikleri ve Bu Evliliklerinden Doğan Çocukları
Authors: Kaya Çetin
Published: January 2025

Çuci, Çinggis Kagan’ın eşi Börte’nin dünyaya getirmiş olduğu ilk erkek evlattır. Ancak Çinggis Kagan’ın oğlu olup olmadığıyla ilgili bazı şüpheler mevcuttur. Çinggis Kagan onu bu duruma rağmen kendi evladı olarak görmüştür. Bu nedenle Çuci de Çinggis Kagan’ın kurmaya çalıştığı sıhrî akrabalıklar kapsamında bazı evlilikler gerçekleştirmiştir. Ayrıca Çuci’nin, Moğolların hasımları üzerinde kurmuş oldukları üstünlük neticesinde ele geçirilen bazı kadınlarla da evlendiği görülmektedir. Yapılan araştırma kapsamında onun on eşinin ismine ulaşılmıştır. Bu eşlerden üç tanesinin ismi Reşîduddîn Fazlullah-ı Hemedânî tarafından kaydedilmiş olmasına rağmen daha kapsamlı bir örneği anonim eser Mu’izzü’l Ensâb’da görülmektedir. Eserlerden edinilen bilgilere göre, bu kadınların isimleri şu şekildedir: Sartak Hatun, Biktutmuş Fucin, Oki Fucin, Sultan Hatun, Kulu Hatun, Kunci Hatun, Kusar, Kavus, Karacin Hatun ve Kuyi Hatun. Bunların bazılarının mensup olduğu boy ve ailelerine dair bilgiler mevcut olsa da diğerleri sadece isim olarak bilinmektedir. İsmi kaynaklarda mevcut olan bu kadınların Çuci’nin on iki erkek evladının annesi olduğu görülmektedir. Ancak Çuci’nin çeşitli kaynaklarda ismine rastlanan on sekiz erkek evladı bulunmaktadır. Bunlardan altı erkek çocuğunun annesinin ismine ulaşılamamıştır. Çuci’nin ayrıca iki de kız çocuğa sahip olduğu bilinmektedir. Onların da anneleri mevcut kaynaklardan tespit edilememiştir. Neticede Çuci’nin yirmi adet evladının olduğu görülmüştür. Bu çocuklardan annesinin ismi tespit edilemeyenler, Çuci’nin adları bilinen eşlerinden mi, yoksa başka kadınlardan mı dünyaya gelmiştir, sorularına dair herhangi bir malumat da mevcut değildir.
In the Light of Anthropometric Data: A Review of Research on the Dynamics of Well-Being in the USSR and Other Socialist Countries
Authors:   St. Petersburg State University, Verniaev I. I.
Published: January 2025

This article provides an analytical overview of contemporary studies on the anthropometric history
concerning the well-being dynamics of the Soviet Union and other socialist countries (Poland, Czechoslovakia,
East Germany etc.). In recent decades, the concept of the “biological standard of living” has emerged, focusing
on the fundamental, “human” dimension of a broader understanding of well-being. Within this framework, fundamental
aspects of the existence of individuals, entire populations, and nations are examined, including the
quantity and quality of nutrition, morbidity, material and psycho-emotional conditions, and the state of the environment.
Indicators of the dynamics of the biological standard of living utilized in this study are not monetary (GDP
per capita, real incomes etc.) but anthropometric (average height, weight etc.) and demographic (mortality, life
expectancy, etc.) characteristics. Anthropometric studies of socialist countries allow overcoming limitations of
official sources on well-being, assessing the contribution of state medical infrastructure and social support to the
biological well-being of individuals, as well as informal self-sustaining practices. They also enable a comparison
of their standard of living with countries of different socio-economic and political structures, detailing the impact
on well-being of both long-term developmental factors and short-term fluctuations and crises. Furthermore, the
article objectively evaluates achievements in overcoming class, professional, regional, ethnic, and gender inequalities.
While the results of anthropometric history studies on the population of the USSR and other socialist countries are significant, there remain unresolved, debatable questions, which are elaborated in detail in this
comprehensive review article.
Escaped Retribution: Nazi War Criminals in Australia [Rev. on: Persian J. Fascists in Exile. Post-War Displaced Persons in Australia. London; New York, 2024]
Authors:   Ural Federal University, Antoshin A. V.
Published: January 2025

The article is a review of the book by Associate Professor at the University of Southern Queensland
(Toowoomba, Australia) Jane Pershian “Fascists in exile. Post-war displaced persons in Australia”, published in
2024. It is dedicated to the fate of collaborators and Nazi war criminals who found themselves in Australia after
the Second World War. It is shown that J. Pershian’s work is distinguished by a very solid source base: the monograph
is based on a large array of documents from the collections of the National Archives of Australia, as well
as on materials from the country’s periodical press. The Australian historian argues that the historical roots of
collaboration were in anti-Soviet nationalism, which was very popular in Central and Eastern Europe during the
interwar period. The review shows that J. Pershian emphasizes the responsibility of the collaborators who ended
up in Australia for the massacres of civilians in the occupied territories during the Second World War. The author pays considerable attention to the participation in Jewish pogroms of members of the Organization of Ukrainian
Nationalists, as well as Lithuanian and Latvian units of the Waffen-SS. J. Pershian proves that a significant part of
Nazi war criminals were able to avoid retribution. J. Pershian characterizes the policy of the Australian authorities
as keeping silent about the existence of this problem, despite the attempts of Jewish and left-wing organizations
in the country to expose Nazi war criminals. The reviewer argues that J. Pershian’s monograph makes a significant
contribution to understanding this painful topic for Australian historical memory. The publication of this work indicates
the presence in Western historical science of researchers striving for an objective coverage of the events
of the Second World War.
Health risks posed by using organic fertilizers
Authors:   Institute of Ecology and Genetics of Microorganisms of Ural Branch of Russian Academy of Sciences – affiliation of Perm Federal Research Centre of Ural Branch of RAS, 13 Goleva St., Perm, 614081, Russian Federation, Kuznetsova M.V. ,   Perm State Medical University named after Academician E.A. Wagner, 26 Petropavlovskaya St., Perm, 614990, Russian Federation, Kochergina D.A. ,   Institute of Ecology and Genetics of Microorganisms of Ural Branch of Russian Academy of Sciences – affiliation of Perm Federal Research Centre of Ural Branch of RAS, 13 Goleva St., Perm, 614081, Russian Federation, Gorovitz E.S. ,   Perm State Medical University named after Academician E.A. Wagner, 26 Petropavlovskaya St., Perm, 614990, Russian Federation
Published: January 2025

Agricultural production has been intensifying for a while and this has made for growing volumes of organic wastes; a part of them is later used as fertilizers. At present, more than 200 types of organic fertilizers are employed in agriculture; they differ in their origin, properties, and effects on the environment. Wastes from agricultural productions typically contain biocides, antibiotics included, and also, which is especially important, pathogens and opportunistic pathogenic microorganisms. Soil contamination with such wastes destroys natural biocenosis. Moreover, pathogens that remain in wastes due to absence of proper treatment can pose serious hazard for humans and animals. Safety of food products made of raw materials, growth of which relies on using organic fertilizers, is a significant component of the overall issue.

This analytical review provides a classification and descriptions of organic fertilizers and data on production volumes and accumulation of animal husbandry wastes. It also describes major biological and chemical factors of health risks associated with using organic fertilizers as well as provides the results of up-to-date studies that focus on negative effects of organic fertilizers. Special attention is paid to literature data about negative impacts exerted on human health and the environment by organic fertilizers that contain antibiotics and salts of heavy metals. It is emphasized specifically that organic fertilizers can very often contain copper, zinc, cadmium, nickel, chromium, arsenic, lead and mercury compounds. Improper use of technologies for treatment of organic fertilizers is shown to result in microbial and chemical pollution in soils and water objects. Methods employed to assess effects of animal husbandry wastes on human health and the environment are described considering international and Russian practices and documents that establish regulatory requirements to safe use of organic fertilizers. The review establishes that a strategy for providing safety of agricultural production should consider risks for human health and include systemic monitoring over quality of the environment and population health.
Anthropometric measures to identify the health risk of obesity among European adolescents (System review)
Authors:   Trakia University, 11 Armeiska St., Stara Zagora, 6000, Bulgaria, Alekova Todorova S.
Published: January 2025

In the last decade, the share of obese adolescents in the European region has been steadily increasing, which is associated with a higher risk and earlier onset of a number of socially significant diseases with a complicated clinical course. Therefore, timely and rapid diagnosis of obesity in adolescents by applying cheap, convenient, non-invasive and reliable indirect methods such as anthropometric indices is crucial in health care settings.

A systematic search and analysis of the available scientific literature was performed to identify relevant articles published over the period between January 2013 and December 2023 in Web of Science, Science Direct, Scopus, Research Gate and PubMed. Seventy full-text publications reporting the application of such anthropometric indices as Body Mass Index, Waist Circumference, Waist-to-Hip ratio and Waist-to-Height Ratio to identify the healthy risk of obesity among European adolescents were considered the most eligible and reviewed in detail. In order to generalize the results and obtain reliable statements, the method of meta-analyses (PRISMA) was applied.
A systematic review covers seventy scientific studies involving 495,251 children and adolescents from twenty-six countries of the European continent. Body Mass Index (BMI) was established to be the leading, most commonly used anthropometric index to identify risk of obesity among adolescents in the European health setting and research. Waist Circumference (WC) and Waist-to-Height Ratio (WHtR) were the next popular indicators of obesity in European adolescents with increasing frequency of application in medical practice and population surveys. Surveys applying anthropometric measurements to determine obesity risk in children and adolescents turned out to be quite heterogenic in terms of sample characteristics, research methods and reported claims.

Body Mass Index, Waist Circumference, Waist-to-Hip ratio and Waist-to-Height Ratio are simple indicators of obesity risk in European adolescents, but with greater practical advantages that determine their widespread use in medical and scientific settings. Until now, BMI has been the leading predictive indicator. In the last decade, the application of Waist Circumference and Waist-to-Height Ratio has grown significantly relying on the scientifically reported good discrimination capabilities. However, it is necessary to actualize and confirm universal international reference cutoff values of the considered anthropometric metrics determining the risk of obesity among European adolescents taking into account not only their age and sex but also stages of puberty and ethnicity, have yet to be actualized and confirmed.
A TRANSIÇÃO ENERGÉTICA EM ANDAMENTO NO MUNDO E NA AMÉRICA LATINA
Authors: Rodrigues Manoel Gonçalves , Costa Fernando José Pereira da
Published: January 2025

Após os choques petrolíferos ocorridos na década de 1970, começou a ganhar espaço a necessidade de encontrar substitutos para o petróleo e seus derivados. Neste caso, promove-se a implementação de iniciativas destinadas à substituição do petróleo e derivados, buscando-se promover a construção de uma matriz energética menos dependente dos combustíveis fósseis, a valer-se de tecnologias inovadoras. Assim, a resposta brasileira, o maior e mais industrializado país da América Latina, vai lastrear-se na bioenergia, estratégia que mais tarde se consolidaria nas variantes etanol e biocombustíveis. A estas agregar-se-iam fontes alternativas como solar e eólica, para além da pré-existente base hidroelétrica do país. Em conjunto, tudo isto daria impulso à transição energética dos combustíveis fósseis aos energéticos renováveis, quer no mundo quer na América Latina. Contudo, em meados dos anos 2010, na América do Sul, o suprimento de energia continuava a depender de combustíveis fósseis, principalmente petróleo e gás natural.
DIFUSÃO DA PROPRIEDADE INTELECTUAL PARA FEIRA CIENTÍFICA DO INSTITUTO FEDERAL DE MATO GROSSO DO SUL POR MEIO DE HISTÓRIAS EM QUADRINHOS
Authors: Santos Jean Jackson Martinez dos , Françozo Rafael Verão
Published: January 2025

A Feira de Ciência e Tecnologia de Campo Grande (FECINTEC) é promovida anualmente pelo Instituto Federal de Mato Grosso do Sul (IFMS) e soma números significativos de trabalhos expostos com potencial inovador e passível de proteção intelectual. Este estudo tem como objetivo a construção de material instrutivo que colabore na disseminação dos conceitos relacionados ao tema de Propriedade Intelectual (PI) aos autores dos projetos da FECINTEC. Para atingir este objetivo, buscou-se identificar e estruturar o conhecimento prévio e lacunas dos participantes sobre fundamentos de PI como base para construção do material instrucional na forma de histórias em quadrinhos (HQ). Como resultado foi elaborado roteiro da HQ a partir da aplicação de conceitos de PI e o desenvolvimento de personagens inspirados em aspectos regionais do município de Campo Grande.
Amide Derivative of Arjunolic Acid TA-1,4-BiP Enhances ROSmediated Apoptosis in Colorectal Cancer Cells
Authors: Bhujel Manohar , Kaloniya Shalu , Jain Dolly , Sripada Lakshminath , Bajaj Avinash , Rao Golakoti Nageswara
Published: January 2025

Introduction:

Arjunolic acid, a well-known natural product with various
medicinal properties, was isolated from the heartwood of Terminalia arjuna. Various
amides of arjunolic acid were synthesized using different aryl and cyclic amines, characterized,
and evaluated for their anti-cancer activities at the National Cancer Institute (NCI).

Method:

All the derivatives were active against all the cell lines of NCI compared to the
parent molecule arjunolic acid. Eight compounds were selected for dose-dependent activity
based on the preliminary results. IC50 of selected eight compounds was evaluated.
Based on IC50 values against various cell lines, compound 2l was further investigated to
understand the mechanism of action against HCT-116 and CT-26 colon cancer cell
lines.

Result:

Mechanistic studies of compound 2l in these two cell lines demonstrated that
compound 2l arrested the colon cancer cells at the G/G1 phase. Compound 2l-treated
cells were also found to have an increased percentage of ROS compared to untreated
cells. It induced apoptosis in both these cell lines.

Conclusion:

Compound 2l was found to inhibit cancer growth in the mice model and
was very effective against all the cancer cell lines. Therefore, it could be used for further
development to treat colon cancer.
PGD2/PTGDR2 Signaling Affects the Stemness of Gastric Cancer Stem Cells by Regulating Autophagy
Authors: Wang Feifan , Tian Hengjin , Gao Peiyao , Cha Zhanshan , Zhang Qiang
Published: January 2025

Background:

Prostaglandin D2 (PGD2) can inhibit the development of gastric cancer
(GC); however, its role in the autophagic death of GC stem cells (GCSCs) remains elusive.
Therefore, this study aims to evaluate the mechanisms by which PGD2 regulates the stemness in
GCSCs.

Methods:

In this study, HGC27-derived GCSCs were employed to knock down PGD2 receptor
2 (PTGDR2). Subsequently, cell stemness and autophagic activity in these GCSCs were assessed
via sphere-forming capacity, transmission electron microscopy, and western blot analyses.

Results:

The results revealed that PGD2 suppressed the stemness of GCSCs and induced GCSCs
autophagy, whereas the downregulation of PTGDR2 had the opposite effect. Furthermore,
PGD2 was also found to inhibit the expression of stemness-associated proteins CD44 and
OCT4, which were blocked by 3-MA and enhanced by RAPA. Moreover, the shPTGDR2 +
PGD2 group indicated higher stemness than the PGD2 group, with 3-MA enhancing this effect
and RAPA reducing this change.

Conclusion:

In summary, this study indicated that PGD2/PTGDR2 signaling affects stemness
and autophagy in GCSCs. The results suggest that PGD2/PTGDR2 signaling may affect the
stemness of GCSCs by regulating autophagy.
Chaperones as Potential Pharmacological Targets for Treating Protein
Aggregation Illness
Authors: Rani Shikha , Tuteja Minkal
Published: January 2025

The three-dimensional structure of proteins, achieved through the folding of the nascent
polypeptide chain in vivo, is largely facilitated by molecular chaperones, which are crucial for determining protein functionality. In addition to aiding in the folding process, chaperones target misfolded proteins for degradation, acting as a quality control system within the cell. Defective protein folding has been implicated in a wide range of clinical conditions, including neurodegenerative and metabolic disorders. It is now well understood that the pathogenesis of neurodegenerative
diseases such as Parkinson's disease, Alzheimer's disease, Huntington's disease, Amyotrophic Lateral Sclerosis, and Creutzfeldt-Jakob disease shares a common mechanism: the accumulation of
misfolded proteins, which aggregate and become toxic to cells. Among the family of molecular
chaperones, Heat Shock Proteins (HSPs) are highly expressed in response to cellular stress and
play a pivotal role in preventing protein aggregation. Specific chaperones, particularly HSPs, are
now recognized as critical in halting the accumulation and aggregation of misfolded proteins in these conditions. Consequently, these chaperones are increasingly considered promising pharmacological targets for the treatment of protein aggregation-related diseases. This review highlights research exploring the potential roles of specific molecular chaperones in disorders characterized by
the accumulation of misfolded proteins
Synergizing CRISPR-Cas9 with Advanced Artificial Intelligence and
Machine Learning for Precision Drug Delivery: Technological Nexus and
Regulatory Insights
Authors: Roy Amrita Arup , Pokale Rahul , Mukharya Anoushka , Nikam Ajinkya N. , Dua Kamal , Rao Bola Sadashiva Satish , Seetharam Raviraja Neelavar , Mutalik Srinivas
Published: January 2025

The evolution of genetic exploration tools, from laborious methods like radiationinduced mutations to the transformative CRISPR-Cas9 system, has fundamentally reshaped genetic
research and gene editing capabilities. This journey, initiated by foundational techniques such as
ZFNs and TALENs and culminating in the groundbreaking work of Doudna and Charpentier in
2012, has ushered in an era of precise DNA alteration and profound insights into gene functions.
The CRISPR/Cas9 system uses the Cas9 enzyme and guides RNA (gRNA) to precisely target and
cleave DNA, with subsequent repair via error-prone NHEJ or precise HDR, enabling versatile gene
editing. Complementary computational tools like E-CRISP and Azimuth 2.0, alongside advanced
deep learning models like DeepCRISPR, have significantly contributed to refining CRISPR experiments, optimizing gRNA efficiency, and predicting outcomes with greater precision. In clinical applications, CRISPR-Cas9 shows great promise for treating complex genetic disorders like sickle cell
disease and β-thalassemia, but faces challenges such as off-target effects, immune responses to viral
vectors, and ethical issues in germline editing. Overcoming these challenges requires meticulous
experimentation and robust regulatory frameworks to ensure responsible and beneficial utilization
of the CRISPR-Cas9 technology across diverse fields, including cancer treatment, genetic disease
therapies, agriculture, and synthetic biology, while continually addressing ethical, safety, and legal
considerations for its advancement and widespread adoption.
Pre-hospital Identification of a Giant Bladder Calculus through Screening Sonography: A Case Report
Authors: Miravent Sergio , Gomes Carla , Simaozinho Paula , Vaz Bruna , lobo Manuel Duarte , de Almeida Rui Pedro
Published: January 2025

Introduction:

Screening ultrasound proves to be remarkably beneficial in pre-hospital settings, particularly in geographically remote areas with technological
constraints and no medical specialties. Urological pathology has a high frequency of occurrence in the emergency department and is part of the
wide range of occurrences that can benefit from this ultrasound screening as a clinical guide for patients.

Case Presentation:

In this case, a patient experiencing lower abdominal pain and symptoms of renal colic sought assistance at a basic emergency service facility.
Utilizing a renal screening ultrasound executed by a sonographer, the clinical team identified images indicative of a significant bladder calculus.
Subsequently, the patient was referred to a referral hospital for a comprehensive evaluation by medical specialties.

Conclusion:

The images obtained in both health units exhibited congruence, indicating that the screening ultrasound, while not intended to replace the
specialized orthodox ultrasound executed by a radiologist, served as a crucial tool for diagnostic presumption, providing consistency in clinical
decision-making for referring patients. This capability allowed emergency physicians to promptly transfer a patient requiring urgent further
investigation to a referral hospital with compelling and substantiated data. This shift in the approach to patient triage in a remote setting could
enhance patient safety.
Automated 3D Quantitative Analysis of Intrapulmonary Vessel Volume on Noncontrast CT in Healthy Individuals
Authors: Ming Ying , Zhang Yu , Xiao Ran , Zhao Ruijie , Wang Jiaru , Piao Sirong , Song Lan , Xu Yinghao , Sui Xin , Song Wei
Published: January 2025

Objective:

This study aimed to compare automated three-dimensional Intrapulmonary Vessel Volume (IPVV) differences between lung and mediastinal
windows in healthy individuals using quantitative measurements obtained from chest Computed Tomography (CT) plain scans.

Methods:

A total of 258 participants (aged 21–83 years) with negative chest CT scans from routine physical examinations conducted between January to
November 2023 were retrospectively enrolled. For each healthy participant, an algorithm was used to automatically extract total lung IPVVs as
well as IPVVs for vessels of specific diameter. Differences in IPVVs were then compared between those extracted using the lung window and
those extracted using the mediastinal window.

Results:

The IPVVs for the entire lung, intrapulmonary arteries, intrapulmonary veins, and small pulmonary vessels (categorized by different diameters)
extracted from the lung window were significantly higher than those extracted from the mediastinal window (p<0.01). No significant sex-based
differences in IPVV were observed for pulmonary arteries and veins with diameters between 0.8 and 1.6 mm, as well as pulmonary veins with
diameters between 2.4 and 3.2 mm. However, in pulmonary arteries and veins with diameters between 1.6 and 2.4 mm, females had significantly
higher IPVVs than males. In all other cases, IPVVs were larger in males than in females.

Conclusion:

This method of automatic IPVV extraction and quantitative assessment has been proven to be feasible. Automated IPVV expression effectively
identified morphological characteristics of intrapulmonary vessels. The study has concluded IPVVs extracted from the lung window to be
generally larger than those extracted from the mediastinal window.
The Effectiveness of Mosquito Larva Monitoring Calendar on Knowledge, Dengue Fever Risk Behavior, and Mosquito Larva Density Rates in Malang, Indonesia
Authors: Zuhriyah Lilik , Alrasyid Harun , Fitri Loeki Enggar
Published: January 2025

Background

The neglected efforts of mosquito larvae observers (typically health cadres and known as Jumantik) require innovative solutions, one of which is the self-monitoring approach with the mosquito larva monitoring calendar (MLMC). This study aimed to test the effectiveness of MLMC in enhancing knowledge, reducing dengue fever (DF) risk behavior, and lowering larva densities.

Methods

A 4-month quasi-experiment was designed to evaluate the use of MLMC. The experimental group implemented MLMC, while the control group implemented the government’s basic program. Both groups were allocated randomly. Baseline and follow-up surveys in experimental and control groups were conducted, each comprising a village and housing estate. As the data was not normally distributed, the Wilcoxon signed-rank test was used to assess within-group changes, while the Student’s t-test or Mann–Whitney U test was used to compare two groups. Spearman’s test examined the relationship between MLMC utility and knowledge.

Results

Compared to control groups, there were improvements in DF risk behaviors for experimental, such as hanging clothes (p=0.008 vs p=0.130), closing the trash (p=0.027 vs p=0.004), and using mosquito nets (p< 0.001 vs p<0.001). In the follow-up survey, the MLMC received positive feedback, correlating with increased knowledge (r=0.240, p=0.006). There was no decrease in the existence of the larval stage in either the experimental or control groups (p=1.00 vs p=0.446). The control group showed reduced positive larva (p<0.001), possibly due to higher education and history of DF although not significant.

Conclusion

MLMC can reducereduce DF risk behavior, increase knowledge, and decrease mosquito larval density, contingent upon sustained compliance, assisted by Jumantik.
Green Synthesis of Copper Oxide Nanoparticles by Hydroethanolic Extract of Rubus ellipticus: Antimicrobial and Antidiabetic Activities
Authors: Kumari Anjana , Kashyap Lokender , Prakash Vinit , K. Gautam Rupesh , Goyal Rajat , Chauhan Vikas
Published: January 2025

Background:

The biosynthesis of nanoparticles of copper oxide nanoparticles via using
plant extracts and phytochemicals has garnered significant interest due to their potential medical
applications. This study focuses on synthesizing CuONPs using Rubus ellipticus leaf extract
(CuONPs-Re) as an efficient reducing agent.

Methods:

The CuONPs-Re were characterized using various techniques:

UV-Visible Spectroscopy:

Observed a peak value at 310 nm because of inherent band gap absorption.

FT-IR Spectroscopy:

Confirmed the existence of functional groups associated with terpenoids,
flavonoids, phenols, and tannins. FE-SEM and HR-TEM Analysis: Indicated that the CuONPs-Re
is spherically shaped with a typical size of 30-50 nm. Antibacterial Activity: The antibacterial efficacy
of CuONPs-Re was tested against Staphylococcus aureus, Escherichia coli, and Aspergillus
nigervia agar well diffusion method. Antidiabetic Activity: Previous studies have shown the potential
of green synthesized CuONPs as hypoglycaemic and hypolipidemic agents. In this study, different
doses of CuONPs-Re in carboxymethylcellulose (CMC) were orally administered for 15
days to alloxan-induced albino Wistar rats. The biochemical considerations, histopathology analyses,
and comparisons among diabetic control, normal, standard (Glibenclamide), and treated animals
were evaluated.

Results:

A significant decrease in the levels of blood glucose (from 293 to 91.5 mg/dl) was observed
in treated experimental rats. Improvements were also observed in their lipid profiles and
pancreatic healing, as compared to the respective standard drugs.

Conclusion:

This study demonstrates that CuONPs-Re has promising potential in the control of
Type-1 diabetes mellitus, aligning with the traditional medicinal use of Rubus ellipticus leaves for
diabetic relief. The findings suggest that CuONPs-Re could serve as an effective alternative to conventional
diabetic treatments.
Analysis of the Roles of Southern Coastal Road Construction Between Tulungagung and Trenggalek Regencies in Developing the Economy of Tasikmadu and Keboireng Villages
Authors: Dewan Dharu Aditya Gangga , Maryunani
Published: January 2025

This study aims to identify the sectors that influence the economy in Desa Tasikmadu and Desa Keboireng. Secondly, it seeks to understand the sustainable economic development policies for these villages following the construction of the southern coastal road (JLS). This research uses Partial Least Squares (PLS) analysis, collecting data related to economic variables after the development of the southern coastal road. The analysis results through SEM PLS testing indicate a significant impact of the economic variables with the presence of the southern coastal road development, providing deep insights into the impact of infrastructure development on the local economy. These findings can serve as the basis for better policy recommendations to harness the potential of the southern coastal road development to improve the welfare of the communities in Desa Tasikmadu and Desa Keboireng. The results show that the JLS has increased investment, reduced unemployment, and encouraged consumption, which significantly drives the village economy. Improved accessibility opens up business opportunities, increases community income, and expands local markets. This development also stimulates the growth of the tourism sector and the distribution of local products, supporting sustainable economic growth in both villages.
 
Abstrak
Penelitian ini bertujuan untuk mengetahui sektor apa saja yang mempengaruhi perekonomian di Desa Tasikmadu dan Desa Keboireng. Kedua, mengetahui kebijakan pembangunan perekonomian Desa Tasikmadu dan Desa Keboireng secara berkelanjutan setelah adanya jalan lintas selatan (JLS). Penelitian ini menggunakan metode analisis PLS, kami mengumpulkan data terkait variabel ekonomi sesudah pembangunan jalan lintas selatan. Hasil analisis melalui uji PSL SEM dapat mengindikasikan adanya pengaruh yang signifikan dalam variabel ekonomi dengan adanya pembangunan jalan lintas selatan, memberikan wawasan mendalam tentang dampak pembangunan infrastruktur terhadap perekonomian lokal. Penemuan ini dapat menjadi dasar untuk rekomendasi kebijakan yang lebih baik dalam memanfaatkan potensi pembangunan jalan lintas selatan untuk meningkatkan kesejahteraan masyarakat di Desa Tasikmadu dan Desa Keboireng. Hasilnya menunjukkan bahwa JLS meningkatkan investasi, menurunkan pengangguran, dan mendorong konsumsi, yang secara signifikan mendorong perekonomian desa. Aksesibilitas yang lebih baik membuka peluang usaha, meningkatkan pendapatan masyarakat, dan memperluas pasar lokal. Pembangunan ini juga memicu pengembangan sektor pariwisata dan distribusi produk lokal, mendukung pertumbuhan ekonomi berkelanjutan di kedua desa.
Determinants of Corrupt Economy: A Tobit Regression Analysis on G20 Countries in the 2012-2021 Period
Authors: Permana Andre Sukma , Bintoro Nugroho Suryo
Published: January 2025

This study aims to analyze the economic determinants of corruption in G20 member countries. Some of the economic factors that are thought to be the cause of corruption based on the author's literature review are GDP per capita, economic growth, inflation, and economic freedom. The data used in this study are annual data from 2012-2021 taken from the World Bank report and Heritage.org. The analysis technique used is Tobit regression with the help of the STATA version 17.0 program as the main research software to process the data of the research variables. The results showed that simultaneously (simultaneously) the independent variable of economic freedom had a significant and positive effect, while the variables of GDP per capita, economic growth, and inflation had an insignificant effect on the probability of corruption levels in the G20 member countries in 2012-2021.
The Impact of Monetary Policy on Stock Price Index Movement
Authors: Sasongko Ghalih , Athoillah Moh.
Published: January 2025

This study aims to analyze the impact and effectiveness of monetary policy on the decline of the Composite Stock Price Index (IHSG) during the COVID-19 pandemic. The research employs a quantitative approach using Ordinary Least Squares (OLS) with equations 2017-2024 to evaluate the relationship between monthly IHSG and variables such as BI Rate and Exchange Rate. The findings reveal that IHSG significantly affects JUB, con-sistent with previous research indicating that monetary expansion by Bank Indonesia en-hances market liquidity and raises IHSG. However,during the pandemic, global uncertainty disrupted the relationship between IHSG and other economic variables, as evidenced by the insignificance of IHSG concerning BI Rate andthe significant impact of Exchange Rate in the first equation, and Dow Jones in the second. The significant influence of Dow Jones on IHSG highlights global market integration and its effect on investor sentiment in Indonesia. The study emphasizes the importance of understanding the relationship be-tween IHSG and economic variables amid global uncertainty.
An Analysis of Competitiveness and Determinants of Indonesia Coal’s Export to Main Destination Country in the 2012-2022 Period
Authors: Rendi Renaldi
Published: January 2025

This study aims to analyze the competitiveness and factors affecting Indonesia's coal export value. The study uses a quantitative research approach and secondary data types. The analytical technique used to determine competitiveness is the Revealed Comparative Advantage (RCA) index, and to identify the factors influencing Indonesia's coal export value, panel data regression with the Gravity Model is used. The results show that Indonesia's coal commodities have competitiveness in the global market, and the factors such as the Gross Domestic Product (GDP), exchange rate, and carbon dioxide emissions have a significant positive impact, while economic distance has a negative impact on Indonesia's coal export value. The implications of the findings in this study suggest that Indonesia needs to consider the challenges and threats to coal demand from destination countries and diversify products beyond coal to maintain foreign exchange revenue.
Ocena jakości życia pacjentów w przebiegu niedokrwistości z powodu niedoboru żelaza
Authors: Piotrowska Anna , Szymczak Marcelina
Published: January 2025

Wstęp. Najczęstszą chorobą hematologiczną jest niedokrwistość z powodu niedoboru żelaza. W leczeniu farmakologicznym stosuje się preparaty doustne/ dożylne żelaza lub przetaczanie Koncentratu Krwinek Czerwonych, w celu uzupełnienia brakującego pierwiastka.
Cel. Celem pracy jest zbadanie oceny jakości życia pacjentów chorujących na niedokrwistość z powodu niedoboru żelaza.
Materiały i metody. W pracy wykorzystano metodę sondażu diagnostycznego i szacowania. Badania przeprowadzono za pomocą Kwestionariusza SF – 36 oraz kwestionariusza ankiety własnego autorstwa.
Wyniki. Analiza wyników badań wykazała, że u znacznej większości respondentów jakość życia uległa zmianie po rozpoznaniu choroby, co może sugerować wpływ choroby na ich codzienne funkcjonowanie, samopoczucie i/lub relacje społeczne. Badania nie wykazały znacznego wpływu płci, wieku, diety oraz wcześniejszych nawyków żywieniowych w zakresie zmiany jakości życia po rozpoznaniu choroby.
Wnioski. Wiek oraz płeć nie powodują istotnych statystycznie zmian w zakresie jakości życia po rozpoznaniu niedokrwistości. Zdecydowana większość badanych respondentów po rozpoznaniu choroby podjęła się zmiany nawyków żywieniowych, przez co poprawiła się ich jakość życia.
Work readiness Generation Z's on diploma programme: The influence internship program and digital literacy
Authors: Naufalin Lina Rifda , Indriayu Mintasih , Sulistyandari Sulistyandari
Published: January 2025

This study aims to examine how Merdeka Belajar Kampus Merdeka (MBKM) and digital literacy affect Generation Z's work readiness for the Diploma Programme. The study involved 169 students from the Diploma Programme of the Faculty of Economics and Business, Jenderal Soedirman University, and 90 students were randomly selected as the sample because the population was homogeneous, meaning that all students had participated in MBKM internships. The data analysis used the Structural Equation Model (SEM) with the Partial Least Square (PLS) method as an alternative. The quality of the structural model was evaluated by testing the measurement index, namely R2. The test results revealed: 1) MBKM internships had a significant impact on the work readiness of generation Z, with a t-test value of 8.323 t critical value of 1.987; 2) digital literacy did not have a significant impact on work readiness, with a t-test value of 0.744 t critical value of 1.987; and 3) there was a simultaneous influence of MBKM internships and digital literacy on work readiness, with a Sig value of 0.0000.05 and R2 of 0.844 indicating that MBKM internships and digital literacy jointly explained 84.4% of the variance in work readiness. Recommendations for policymakers regarding diploma programs include integrating digital literacy as a fundamental component of the curriculum across all disciplines, enhancing access to internship opportunities via industry collaborations, employing virtual internships and remote work simulations, and upgrading infrastructure while ensuring access to technology.
Children’s and Their Parents’ Experiences With Home-Based Guided Hypnotherapy: Qualitative Study
Authors: Ganzevoort Ilse N , van der Veen Adriëlla L , Alma Manna A , Berger Marjolein Y , Holtman Gea A
Published: January 2025

Background

Management of children with functional abdominal pain (FAP) or irritable bowel syndrome (IBS) is difficult in primary care. When education and reassurance do not alleviate symptoms, primary care physicians lack treatment options for children with FAP or IBS. Home-based guided hypnotherapy is a promising treatment because of its accessibility. To address feasibility, it is of utmost importance to take experiences from children and their parents into account.

Objective

We aimed to explore children’s and their parents’ experiences with home-based guided hypnotherapy for children with FAP or IBS.

Methods

This qualitative study used open-ended questions from a questionnaire and in-depth semistructured interviews with children and their parents who had a hypnotherapy intervention prescribed. The interviews were audio-recorded and transcribed verbatim. Data were collected and analyzed iteratively using thematic content analysis.

Results

A total of 76 children were eligible, and we collected questionnaire data from 56 children. A total of 23 interviews were conducted with 10 children and 15 parents. Six themes emerged from questionnaire data and interviews: impression of the exercises, not for everyone, influence of perceived effect, integrating exercises in daily life, content and practicalities of the website, and customization to personal preferences. Children with FAP or IBS experienced home-based guided hypnotherapy and the exercises differently, ranging from boring to fun. From interviews with the parents, it emerged that hypnotherapy is not suitable for everyone; for example, when children are very young or have a low developmental level, cannot sit still, cannot surrender to the exercises, or are too energetic or stressed, it might be difficult to comply. Experiences were shaped by the influence of a perceived effect and to which extent children were able to integrate exercises in daily life. The content and practicalities of the website also influenced experiences, and hypnotherapy that is adaptable to personal preferences, including by appearance and content, would be highly appreciated.

Conclusions

The children and parents experienced home-based guided hypnotherapy differently, ranging from boring to fun. Hypnotherapy might be difficult or boring for some children. The children enjoyed hypnotherapy when they liked the topic or story, felt positive effects, could easily integrate exercises in daily life, or enjoyed the website in general. The children’s experiences and adherence can be further improved by adding short exercises and customizing hypnotherapy to their personal preferences on the website’s appearance and content. This could increase effectiveness but must be studied further.
The Evolution of Uroflowmetry and Bladder Diary and the Emerging Trend of Using Home Devices From Hospital to Home
Authors: Li Ming-wei , Tsai Yao-Chou , Yang Stephen Shei-Dei , Pong Yuan-Hung , Tsai Yu-Ting , Tsai Vincent Fang-Sheng
Published: January 2025

Although uroflowmetry and bladder diaries are widely used for noninvasive evaluation of lower urinary tract symptoms, they still have limitations in diagnostic capability and users’ convenience. The aim of this paper is to discuss potential solutions by reviewing (1) the evolution and current clinical use of uroflowmetry and bladder diary, including clinical guidelines, daily practice applications, and their historical development; (2) a growing trend toward using home devices with various technologies; and (3) a comprehensive comparison of the strengths and weaknesses of these home devices. In our opinion, the following points can be highlighted: (1) the emerging trend of using home devices can enhance diagnostic capabilities through repeated measurements and the convenience of at-home testing and (2) home devices, which provide both frequency-volume and uroflowmetry information, have the potential to transform the management of lower urinary tract symptoms.
Exploring the Impact of Digital Peer Support Services on Meeting Unmet Needs Within an Employee Assistance Program: Retrospective Cohort Study
Authors: Nagra Harpreet , Mines Robert A , Dana Zara
Published: January 2025

Background

The World Health Organization estimates that 1 in 4 people worldwide will experience a mental disorder in their lifetime, highlighting the need for accessible support.

Objective

This study evaluates the integration of digital peer support (DPS) into an employee assistance program (EAP), testing 3 hypotheses: (1) DPS may be associated with changes in EAP counseling utilization within a 5-session model; (2) DPS users experience reduced sadness, loneliness, and stress; and (3) DPS integration generates a positive social return on investment (SROI).

Methods

The study analyzed EAP utilization within a 5-session model using pre-post analysis, sentiment changes during DPS chats via natural language processing models, and SROI outcomes.

Results

Among 587 DPS chats, 432 (73.6%) occurred after business hours, emphasizing the importance of 24/7 availability. A matched cohort analysis (n=72) showed that DPS reduced therapy sessions by 2.07 per participant (P<.001; Cohen d=1.77). Users’ messages were evaluated for sentiments of sadness, loneliness, and stress on a 1-10 scale. Significant reductions were observed: loneliness decreased by 55.04% (6.91 to 3.11), sadness by 57.5% (6.84 to 2.91), and stress by 56.57% (6.78 to 2.95). SROI analysis demonstrated value-to-investment ratios of US $1.66 (loneliness), US $2.50 (stress), and US $2.58 (sadness) per dollar invested.

Conclusions

Integrating DPS into EAPs provides significant benefits, including increased access, improved emotional outcomes, and a high SROI, reinforcing its value within emotional health support ecosystems.
Smart Home User Perception in Canada: National Cross-Sectional Survey (Preprint)
Authors: Hasan Zara , Campbell Jessica Percy , Mishra Pratik Kumar , Buchan Jacob , Zheng Tun , Bianchi Andria , Hoey Jesse , Chu Charlene H , Khan Shehroz S
Published: January 2025

BACKGROUND

Smart Home Technology (SHT) encompasses Internet-connected interfaces, sensors, monitors, devices, and appliances, which are networked together to allow for automation as well as control of the home environment. They can facilitate tasks such as taking medication or send emergency fall alerts. However, their widespread use comes with concerns of power imbalances between users, technology companies, marketers, state actors, and others regarding data collection, its use and disclosure, as well as security issues such as the potential for data breaches. Despite this, little is known about how Canadians perceive and understand their SHTs. Given Canada’s unique demographic diversity and distinct context, examining Canadian perspectives is necessary to advancing this body of research.

OBJECTIVE

This paper explores user perceptions of SHTs in Canada with a focus on four themes: privacy, purpose of data collection, risks and benefits, and safety.

METHODS

An online cross-sectional survey was conducted between March 7 – April 24, 2023 across Canada to collect self-reported demographic information and perceptions around the four aforementioned themes through multiple-choice and optional short response questions. The quantitative data was exported into SPSS and Python programming language for further analysis.

RESULTS

Survey data from a total of 881 SHT users was analysed. The presence of privacy cynicism was displayed via user mistrust (294/881, 33%), uncertainty (281/881, 32%), powerlessness (325/881, 37%), and digital resignation (232/881, 26%) as self-reported by users. Many users displayed a willingness to trade privacy for perceived benefits, such as convenience (503/881, 57%). Users also flagged enhanced safety and daily convenience as a beneficial feature of SHTs (492/881, 56%). Contrary to previous Internet or smart home research, most (801/881, 91%) participants reported having read their SHT Terms of Use documents upon setup.

CONCLUSIONS

This study illustrates themes of privacy cynicism and digital resignation within Canadian users, which are prevalent within an emerging body of related literature on Internet platforms more generally, and highlights ways in which to mitigate these patterns. The gap between user privacy preferences and options underscores the need for stronger user-centric design and data protection regulation. These insights and suggestions provide valuable guidance for policymakers and industry stakeholders navigating the complex landscape of SHT adoption.
A Study on Chinese-English Translation of Henan Tourism Texts from the Perspective of Reception Aesthetics Theory
Authors: Lou Baocui , Xu Xinyi
Published: January 2025

With the vigorous development of tourism industry in China, studies on tourism translation have received much attention. Henan is the province with abundant tourism resources in the Central Plains and attracts many tourists every year. As a direct means of international promotion of tourism resources, tourism texts translation is of the great importance. Based on the data of Henan tourism texts, this study analyzes the existing problems in translation of Henan tourism texts with the intention to improve translation quality from the perspective of reception aesthetics theory. It is found that spelling errors and translation errors can be found in the translated texts and that there is a lack of attention to the reader-oriented principle in the translated texts. Various translation techniques should be adopted by the translator to meet the reader’s expectations. This study can provide valuable insights to Chinese-English translation practice of tourism texts and is of importance to the study of tourism texts.