bluuebunny/crossref_metadata_2025 huggingface dataset:
Correlation of serum Uric Acid levels with Blood Pressure and Glycated Hemoglobin in Prediabetes and Diabetes patients
Authors: AHMAD AFZAL , Zahra Nadia Az , Rochlani Dimpal
Published: June 2024

Background: Increased serum uric acid (SUA) through a series of pathophysiological sequelae like oxidative strain, inflammation and endothelial vascular impairment causes different diseases.
Aim: Evaluate association between serum uric acid levels and hypertension, blood sugar and glycated hemoglobin in prediabetes, diabetes and healthy control.
Methods: Cross sectional study conducted in 120 subjects, divided equally into three groups: 40 prediabetes, 40 type 2 Diabetes (T2DM) and 40 healthy controls. Data was collected using a proforma, covering particulars related to hypertension, fasting blood sugar (FBG), glycated hemoglobin (HbA1c) and the levels of SUA. SPSS software was used for analysing the data.
Results: The age- and sex-matched prediabetic and diabetic groups had significantly higher systolic and diastolic blood pressures compared to control group. Diabetes markers FBG and HbA1c were recorded highest in the T2DM group, which shows a significant difference in mean compared to prediabetes and the control group. SUA levels were highest in diabetes but found an insignificant difference with prediabetes, whereas the control group showed significant differences (4.4±0.5, p<0.05) with prediabetes (7.1±2.4) and diabetes (7.6±1.5). A significant and positive correlation was recorded between SUA and blood pressure, FBG and HbA1c in the diabetes group. In prediabetes, SUA was found to have a positive association with only systolic blood pressure (SBP) and FBG. 
Conclusion:  Severity of disease progression in patients with hypertension and diabetes, SUA can probably be used as an early biochemical marker. So, assessment of serum uric acid as a routine investigation may be recommended for evaluating disease progress.
Comprehensive Management of Geriatric Syndrome in Level Two Health Facilities
Authors: Endah Felia , Ningrum Putu , Lusiana
Published: June 2024

Background: The elderly population is increasing every year, especially in developing countries. Geriatric syndrome is a condition where there is a disturbance in the multifactorial system in the elderly due to decreased function.
Case: Woman, 85 years old, came with the main complaint of weakness, accompanied by not wanting to eat and drink since 3 days. The patient could not sleep for 2 days, coughed up phlegm since 1 month ago, accompanied by shortness of breath. One week ago the patient complained of liquid bowel movements accompanied by mucus and dregs. The patient has a history of high blood pressure and was diagnosed with stage III heart failure. From physical examination, GCS E4V4M5, blood pressure 130/80, pulse 72x/m, respiration 20x/m, temperature 37 C, oxygen saturation 94%, anemic conjunctiva, rhonchi in both lung fields, epigastric tenderness, non-pitting upper leg edema. Laboratory examination, Hb 8.0 gr/dL on the second day to 6.7 gr/dL, LED 72 mm/hour. AP chest photo shows consolidation in the middle zone of the right lung and left lower zone, increased vascular pattern with chepalization, CTR 72%. The patient was given initial management of 40 mg omeprazole injection and 4 mg ondansetron.
Discussion and conclusion: Based on the results of the anamnesis, physical examination, and support examination, the patient's complaints constitute a geriatric syndrome. The management provided includes medical management to deal with systemic complaints as well as educating the family about the patient's condition.
Keywords: Elderly, geriatric syndrome
Fibromuscular Dysplasia: Renal Artery Dissection and Infarction in a Young Male
Authors: Bdiwi Mustafa , Dayco John , Uddin Mohammed , Afonso Luis
Published: June 2024

Fibromuscular dysplasia is an abnormal cell growth of the arterial wall that usually affects the renal and carotid arteries. It may lead to stenosis, tortuosity, aneurysm, or dissection of the artery and can potentially compromise the circulation from ensuing total occlusion and infarction of the recipient area. We report a case of a young male who presented with severe acute abdominal pain in the right side of the abdomen associated with nausea, vomiting, and constipation. Computed tomography of the abdomen with intravenous contrast showed acute renal infarction of a focal area at the lower pole of the right kidney, subsequent computed angiography showed dissection of a segmental branch of the right renal artery associated with fibromuscular dysplasia and beading appearance of the right renal artery. The renal function test and urinalysis were both normal. The patient was treated with unfractionated heparin infusion, with the resolution of abdominal pain, he was subsequently discharged home uneventfully on oral aspirin.
Development of Geographic Information System for Government With Extreme Programming and User-Centered Design Methods
Authors: Subhan Subhan , Suciningsih I Gusti Ayu
Published: June 2024

Software development is among the most powerful needs in every organization and industry in the current generation. It is used to help the functionality of their system by using the software development guide named Software Development Life Cycle (SDLC). Various system developments have been conducted, including developing a public complaint service system. This research applies extreme programming (XP) and User-Centered Design (UCD) development methods to develop the geographic information system for the Badan Narkotika Nasional (BNN) Kediri City complaint service. These development methods are expected to meet user expectations. Also, it can reduce the time required to develop products with results that will be shown by conducting usability testing and validity tests. This research applied extreme programming and user-centered design development methods, both quantitative and qualitative for user testing. The application was successfully developed using XP and UCD development methods. The Kediri City BNN complaint service application was successfully developed in several stages: planning, implementing the design, and program code, followed by the evaluation stage. In the evaluation stage, usability testing results on the geotagging mobile application of the Kediri City BNN complaint service obtained a total score of 92.75% with a very good interpretation, and the validation testing results obtained a value of 100%. Applying extreme programming and user-centered design as a development method produces high usability testing and user experience because, in the development stage, it prioritizes interactions and user opinions.
Convergence of green and sustainable principles from the perspective of economic democracy in Indonesia
Authors:   Faculty of Law, Universitas Sebelas Maret, Surakarta, Indonesia, Subekti Nanang , Handayani I. Gusti Ketut Ayu Rachmi ,   Faculty of Law, Universitas Sebelas Maret, Surakarta, Indonesia, Hidayat Arief ,   Constitutional Court of Indonesia, Jakarta, Indonesia
Published: June 2024

Despite a broad agreement on the significance of incorporating environmental consciousness and sustainability into policies, these have not been sufficiently prioritized in the practice of economic democracy. Such principles are essential for the operation of the national economy and are mandated by Indonesia's constitution. This study introduces the critical idea of integrating environmental and sustainability principles within economic democracy to foster economic development. It utilizes normative legal research methods, using both primary and secondary legal sources like the Constitutional Court Law, the 1945 Constitution, academic journals, and theories on economic democracy. The research finds a robust connection between environmental and sustainability principles, suggesting that economic development should harmonize environmental conservation, management, quality improvement, and sustainability with economic growth. In Indonesia, economic interests often dominate environmental considerations. However, ensuring prosperity and a healthy environment as part of human rights remains essential. Environmental considerations are crucial for societal efforts to enhance well-being. Combining these principles could lead to laws that address environmental crises and safeguard citizens' constitutional rights, benefiting both the environment and community welfare.
Bluetongue virus in Culicoides spp. in Manabí province, Ecuador
Authors: Centeno Mariella , Chliliquinga Denisse , Velázquez José , De La Torre Euclides , Jarrín David , Maldonado Alex , Alava Jimmy , Barrera Maritza
Published: June 2024

Bluetongue is a viral disease that affects sheep, cattle and other domestic or wild ruminants. Different species
of Culicoides transmit the virus (BTV). High BTV seroprevalence was found in farms of Manabí and other
two provinces of Ecuador, but the presence of the virus in the Culicoides spp. vector has not been reported. In
the current study, the main goal was to demonstrate the presence of BTV in Culicoides in Ecuador for the first
time and characterize the species of Culicoides collected in farms located in the central-east area of Manabí
province. Six farms were selected to be monitored by BTV c-ELISA. All the 100 tested animals were
positive. Using a CDC trap with ultraviolet light placed in three BTV-positive farms for three nights, 2240
specimens of Culicoides were collected. Six different Culicoides species have been identi-fied, which were
presented in different abundance percent: 62% C.insignis; 7% C. batesi; 1.8% C.foxi; 1.8% C.diabolicus;
15.48% C.crepuscularis; 12% C.antunesis. These last two species have been identified for the first time in
Ecuador. Q-PCR detected BTV RNA in the homogenates of female midges collected in each farm, so it was
demonstrated that the epidemiological cycle of the virus is completed; since female midges infected with
BTV were found, it is too a novel result for Ecuador.
Keywords: Bluetongue, BTV, Culicoides, cattle, real-time PCR, competitive ELISA, Ecuador, Manabi
Examining a Fully Automated Mobile-Based Behavioral Activation Intervention in Depression: Randomized Controlled Trial
Authors: Santopetro Nicholas , Jones Danielle , Garron Andrew , Meyer Alexandria , Joyner Keanan , Hajcak Greg
Published: June 2024

Background

Despite significant progress in our understanding of depression, prevalence rates have substantially increased in recent years. Thus, there is an imperative need for more cost-effective and scalable mental health treatment options, including digital interventions that minimize therapist burden.

Objective

This study focuses on a fully automated digital implementation of behavioral activation (BA)—a core behavioral component of cognitive behavioral therapy for depression. We examine the efficacy of a 1-month fully automated SMS text message–based BA intervention for reducing depressive symptoms and anhedonia.

Methods

To this end, adults reporting at least moderate current depressive symptoms (8-item Patient Health Questionnaire score ≥10) were recruited online across the United States and randomized to one of three conditions: enjoyable activities (ie, BA), healthy activities (ie, an active control condition), and passive control (ie, no contact). Participants randomized to enjoyable and healthy activities received daily SMS text messages prompting them to complete 2 activities per day; participants also provided a daily report on the number and enjoyment of activities completed the prior day.

Results

A total of 126 adults (mean age 32.46, SD 7.41 years) with current moderate depressive symptoms (mean score 16.53, SD 3.90) were recruited. Participants in the enjoyable activities condition (BA; n=39) experienced significantly greater reductions in depressive symptoms compared to participants in the passive condition (n=46). Participants in both active conditions—enjoyable activities and healthy activities (n=41)—reported reduced symptoms of anxiety compared to those in the control condition.

Conclusions

These findings provide preliminary evidence regarding the efficacy of a fully automated digital BA intervention for depression and anxiety symptoms. Moreover, reminders to complete healthy activities may be a promising intervention for reducing anxiety symptoms.
mHealth Apps in the Digital Marketplace for Pediatric Patients With Cancer: Systematic Search and Analysis
Authors: Skeens Micah A , Jackson Daniel I , Sutherland-Foggio Malcolm S , Sezgin Emre
Published: June 2024

Background

The substantial increase in smartphone ownership has led to a rise in mobile health (mHealth) app use. Developing tailored features through mHealth apps creates a pathway to address the health care needs of pediatric patients with cancer and their families who have complex care needs. However, few apps are designed specifically to integrate with pediatric cancer care.

Objective

This study reports a systematic search and analysis of mHealth apps available on the Apple App (iOS) and Google Play (Android) stores designed for pediatric cancer through a list of features that serve (1) patients, (2) caregivers, or (3) both audiences.

Methods

Following PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines, we reviewed apps for pediatric patients with cancer and caregivers available as of January 30, 2024. We searched the Apple App and Google Play stores with a list of keyword combinations focusing on pediatric cancer care. The inclusion criteria were (1) specifically apps targeted toward pediatric patients with cancer, their families, or both; (2) available in either app store; and (3) available in English. Apps were assessed using the Mobile Application Rating Scale (MARS). The MARS is a quality assessment for mHealth apps, including components of engagement, functionality, aesthetics, and informational quality (5-point Likert scale items—1: low and 5: high quality).

Results

In total, 22 apps were identified and 17 of those apps were available on both platforms. The most popular features (n=12) were resource sharing, symptom tracking, reminders, care team connections, journaling, community support, medication tracking, data visualizations, and appointment tracking. Features and interfaces were designed for caregivers (n=9) more frequently than the patients (n=7) while a subset of apps created options for both users (n=6). A total of 16 apps received positive reviews (mean 4.4, SD 0.59; Min=3.1, Max=5.0). A small subset (n=3) achieved over 5000 downloads; however, the majority (n=15) had fewer than 500. More than half (n=12) of the apps were not available in English. Apps requested access to a range of device functionalities to operate (mean 2.72, SD 3.13; Min=0, Max=10). Out of 22, a total of 17 apps were publicly accessible. The mean MARS scores for the apps ranged from 1.71 (SD 0.75) to 4.33 (SD 0.82). Overall, apps scored high on functionality (mean 3.72, SD 0.54) but low on engagement (mean 3.02, SD 0.93).

Conclusions

Our review highlights the promising yet underdeveloped potential of mHealth apps in pediatric oncology care, underscoring the need for more inclusive, comprehensive, and integrative digital health solutions. Future developments should actively involve key stakeholders from the pediatric oncology community, including patients, families, and health care professionals, to ensure the apps meet specific needs while addressing linguistic and cultural barriers.
From Fax to Secure File Transfer Protocol: The 25-Year Evolution of Real-Time Syndromic Surveillance in England
Authors: Elliot Alex J , Hughes Helen E , Harcourt Sally E , Smith Sue , Loveridge Paul , Morbey Roger A , Bains Amardeep , Edeghere Obaghe , Jones Natalia R , Todkill Daniel , Smith Gillian E
Published: June 2024

The purpose of syndromic surveillance is to provide early warning of public health incidents, real-time situational awareness during incidents and emergencies, and reassurance of the lack of impact on the population, particularly during mass gatherings. The United Kingdom Health Security Agency (UKHSA) currently coordinates a real-time syndromic surveillance service that encompasses 6 national syndromic surveillance systems reporting on daily health care usage across England. Each working day, UKHSA analyzes syndromic data from over 200,000 daily patient encounters with the National Health Service, monitoring over 140 unique syndromic indicators, risk assessing over 50 daily statistical exceedances, and taking and recommending public health action on these daily. This English syndromic surveillance service had its origins as a small exploratory pilot in a single region of England in 1999 involving a new pilot telehealth service, initially reporting only on “cold or flu” calls. This pilot showed the value of syndromic surveillance in England, providing advanced warning of the start of seasonal influenza activity over existing laboratory-based surveillance systems. Since this initial pilot, a program of real-time syndromic surveillance has evolved from the single-system, -region, -indicator pilot (using manual data transfer methods) to an all-hazard, multisystem, automated national service. The suite of systems now monitors a wide range of syndromes, from acute respiratory illness to diarrhea to cardiac conditions, and is widely used in routine public health surveillance and for monitoring seasonal respiratory disease and incidents such as the COVID-19 pandemic. Here, we describe the 25-year evolution of the English syndromic surveillance system, focusing on the expansion and improvements in data sources and data management, the technological and digital enablers, and novel methods of data analytics and visualization.
PARTISIPASI MASYARAKAT DALAM PENGELOLAAN DAERAH ALIRAN SUNGAI MANDAR BERORIENTASI LINGKUNGAN HIDUP
Authors: Astomo Putera
Published: June 2024

Abstract
Society’s participation in utilizing river water in watershed areas must be conducted to maintain and protect the surrounding environment preventing environmental pollution. However, such efforts are not implemented, resulting in river contamination and potentially cause harmful side effects if consumed. This research observes MANDAR Watershed, managed by Tangan Baru Village in Limboro sub-district and Kalumammang Village located in Alu sub-district within Polewali Mandar District, West Sulawesi Province. Both villages involve the community’s participation in managing the Mandar Watershed but must be supported by the community’s effort in maintaining and protecting the environment surrounding the watershed. Accordingly, it is necessary to know how to achieve environmental oriented participation. This research adopted the sociolegal method, which observes the relationship between the current national legal system regulating watersheds and the environment with the social behaviour of the villagers utilizing the MANDAR river water for their survival.
 
Intisari
Partisipasi masyarakat untuk memanfaatkan air sungai dalam wilayah DAS harus disertai dengan upaya menjaga dan melindungi kelestarian lingkungan hidup di sekitarnya agar tidak terjadi pencemaran lingkungan hidup. Permasalahan yang selalu timbul adalah tindakan masyarakat memanfaatkan air sungai tidak disertai dengan upaya menjaga dan melindungi kelestarian lingkungan hidup di sekitarnya sehingga menyebabkan air sungai tercemar akhirnya berdampak buruk terhadap kesehatan manusia jika dikonsumsi. DAS yang diteliti adalah DAS MANDAR yang dikelola Pemerintah Desa Tangan Baru (Kecamatan Limboro) dan Desa Kalumammang (Kecamatan Alu) di Kabupaten Polewali Mandar Provinsi Sulawesi Barat. Kedua Pemerintah Desa tersebut melibatkan partisipasi masyarakat untuk mengelola DAS MANDAR, tetapi harus seimbang dengan sikap dan perilaku masyarakat yang mampu menjaga dan melindungi kelestarian lingkungan hidup di sekitar DAS MANDAR sehingga permasalahan yang muncul adalah bagaimana perwujudan partisipasi masyarakat di Kabupaten Polewali Mandar Provinsi Sulawesi Barat dalam pengelolaan Daerah Aliran Sungai MANDAR yang berorientasi lingkungan hidup? Penelitian partisipasi masyarakat di Desa Tangan Baru dan Desa Kalumammang dalam pengelolaan DAS MANDAR menggunakan metode penelitian hukum sosio legal di mana melihat hubungan antara eksistensi Sistem Hukum Nasional (peraturan perundangundangan) mengatur pengelolaan DAS dan lingkungan hidup dengan perilaku sosial masyarakat desa memanfaatkan air sungai dalam wilayah DAS MANDAR untuk kelangsungan hidup.
Research on the Impact of Digital Customer Orientation on Value Co-creation in the Tourism Industry
Authors: Zhang Haoan , Ren Yanping
Published: June 2024

With the rapid development of digital technologies, customer-oriented strategies have become a key driver for value co-creation in the tourism sector. This paper examines the applications of digital tools such as social media, mobile applications, and virtual reality in the tourism industry, exploring how these technologies enhance customer engagement and personalized experiences, thereby increasing customer satisfaction and business revenue. The study finds that by effectively leveraging these digital tools, tourism enterprises can better understand customer needs and achieve greater flexibility and responsiveness in service delivery, promoting overall value co-creation in the tourism industry. Additionally, the paper discusses the long-term impact of digital customer orientation on the sustainable development of the tourism industry and how enterprises can strategically integrate these technologies to optimize customer experiences and enhance competitiveness.
Video Blog (Vlog): Media Innovation in Mathematics Learning explores creative mathematics learning
Authors: Zahroh Umy , Ariansyah Fitroh , Farooq Syed Muhammad Yousaf
Published: June 2024

Students often need help acquiring information about mathematics delivered in class within a limited timeframe, without the opportunity for repeated discussions or comprehensive review. Additionally, retaining previously taught material might be challenging. Hence, educators must establish efficacious instruction that stems from pioneering pedagogy. One of the advancements is the utilization of educational media. This study examines the existing literature about using video blogs (vlogs) as a medium for educational purposes. This study employs the Systematic Literature Review (SLR) methodology. Data was gathered by systematically collecting and scrutinizing articles about vlogs as an educational medium published between 2013 and 2023. This research utilized eight papers, theses, and dissertations from reputable national journals or conferences. The materials were collected through the Publish or Perish tool. The research findings indicate that including vlog media in the learning process can enhance the efficacy of instruction and positively impact students' learning outcomes. Thus, vlogs can be utilized as an educational tool for mathematics instruction. The essay provides a comprehensive analysis of the practicality of this innovation in enhancing mathematics education.
What are junior high maths students' Edmodo interests and learning outcomes?
Authors: Shania Faridatus , Inganah Siti , Rosyadi Alfiani Athma Putri , Afolaranmi Adebayo Ola
Published: June 2024

This research aims to describe students' interests and learning outcomes after using the Edmodo application. This type of research is descriptive by categorizing and using a quantitative approach. The subjects of this research were class VIIB students at SMP Negeri 2 Tegalsari. To see students' interest after studying using Edmodo through data obtained from learning interest questionnaires and interviews given to students. Meanwhile, it is obtained from the quiz/test scores to see student learning outcomes. Based on the results of data analysis, it was found that the use of the Edmodo application in mathematics learning went according to expectations seen from student participation from the beginning of the learning activity to the end and was following the RPP, so it could be said to be quite successful. The students' learning interest results are categorized as good because they meet the three predetermined indicators: feelings of joy, attention, interest, and involvement. Student learning outcomes are also classified as having a reasonably good score so that it can be said that students can understand the learning material and solve problems well.
The main mechanisms for the implementation of codes of corporate ethics in the activities of multinational corporations
Authors: Kasatkina Aleksandra S. , Ulugnazarov Azizbek A.
Published: June 2024

The corporate code of ethics of a transnational corporation establishes a global standard for business ethics, serving as a corporation’s “calling card” and a self-regulatory mechanism that enhances the corporate identity. The reputational aspect of corporate codes of ethics aims to demonstrate the transparency of the corporation in the relevant industry market, thereby fostering a certain level of trust from of external stakeholders. This article addresses fundamental issues concerning the legal nature of corporate codes ethics. It analyses the main mechanisms and methods of implementing these codes in the daily business activities of corporations. Specifically, the following issues are examined: the position and role of codes within the framework of local regulatory acts, employees’ adherence to codes within the scope of labor discipline, incentivizing counterparties to adhere not only to contract terms but also to the code norms and incorporation of corporate codes of ethic into the compliance system. Throughout the exploration of these topics, the authors address the key challenges and trends in the adoption, application and adherence to corporate codes of ethics by corporations. The paper provides critical analysis of the role of corporate codes of ethics in regulating labor and contractual relations involving corporations, as well as within the compliance system. The research methodology is based on formal logic, comparative legal, dialectical, and system-structural methods.
The evolution of digital legal proceedings in African countries: Nigeria, Egypt and South Africa in the focus
Authors: Rusakova Ekaterina P.
Published: June 2024

The adoption the Digital Transformation Strategy for 2020-2030 by the African Union stands out as a significant milestone in advancing digital agendas and programs across African countries. The integration of digital technologies into the society and economy is acknowledged as a catalyst for fostering innovative, inclusive and sustainable growth. Formulated upon existing ICT initiatives in Africa, this strategy not only holds socio-economic importance for the continent’s development by also play a pivotal role in ensuring digital governance. African countries grapple with challenges such as unemployment, poverty, and digital divide, making the coordinated policy of all states critical for the successful realisization of the digital strategy. Essential components include adequate financing, regional integration, international cooperation and harmonization. The digital transformation of justice holds the potential to address various issues concerning accessibility and efficiency of the judicial method of safeguarding the rights and legitimate interests of citizens and business entities. A notable concern is the lack of trust in the judicial system by over 53% of Africans, emphasizing the need for improvements in legal systems to combat delays, corruption, and hight litigation costs. Moreover, the digital gender gap poses a particular challenge, with only 24% of women in Africa having access to the Internet. Rural women, facing additional societal barriers, encounter difficulties in accessing legal aid, property and economic opportunities. Leveraging digital technologies to enhance justice systems, including through remote court participation and electronic case management, can mitigate these challenges. By facilitating gender-inclusive access to justice, reducing costs and processing time, and enhancing overall judicial efficiency, digital transformation in the realm of justice may pave the way for more equitable legal processes. The theoretical and methodological foundation of the study is rooted in a dialectical approach to understanding social processes and legal phenomena. The objectives of this study also necessitate application of a number of general scientific methods. Methods of analysis and synthesis are employed to examine legal trends in the progression of electronic justice, as well as to compare the evolution of digital justice in Egypt, Nigeria, and South Africa. The unique characteristics of the study’s object - civil legal relations emerging during the exrercise of the right to judicial protection in electronic format - also require the use of private law methods.
Cognitive underpinnings of misperceptions in morphed humor
Authors: Ageev Sergei V. , Pushkarev Evgeny A. , Antonenko Natalia V.
Published: June 2024

A meme as a cultural and semiotic phenomenon has been actively studied within the framework of humor research; however, the question why memes may not elicit a humorous response remains unanswered. This article examines the causes of typical cognitive errors in the perception of humor in the so-called morphed units (memes, image macros, photoshopped images and virals) characterized by a combination of signals of one or different modalities and potentially capable of eliciting a humorous response in the meme consumer. The goal of the study is to describe and classify such errors on the example of a morphed unit from the sad keanu meme cycle. The conducted survey yielded empirical data permitting further qualitative analysis of the respondents' answers regarding the perception of the proposed meme. The obtained results show that in an ideal situation a stimulus image should metonymically activate script structures essential for the understanding of a morphed unit; a script may include allusive experiences which correlate with previously appropriated culture-specific situations. The paper defines meme interpretation errors as related either to the process of perceiving a stimulus at the level of the i consume memes metascript or а cognitive failure occurring during the activation of the scripts constituting the humorous opposition if only the relevant scripts are conceptualized and internalized by the individual. Any type of interpretation failure may be attributed to partial or zero cultural literacy in the meme consumer. A failed humorous response in the situations of sufficient cultural literacy of the subject may be explained by social and pragmatic factors, such as the consumer’s norms and values which may differ from those of the meme originator. The study claims that the main source of cognitive errors lies in the inability of a meme consumer to activate the scripts (or their parts) relevant to the understanding of humor. This methodology can be applied for any multimodal humour research.
Semantic Schema Extraction in NoSQL Databases using BERT Embedding
Authors: BELEFQIH SAAD , ZELLOU AHMED , BERQUEDICH MOUNA
Published: June 2024

NoSQL databases, valued for flexibility and scalability, pose analytics
challenges due to their schema-less nature. Automatic schema extraction
is crucial, with existing techniques limited in handling nested
structures. Leveraging Natural Language Processing (NLP) advancements,
this paper introduces a novel BERT embedding-based approach for
extracting schemas from NoSQL databases. The method analyzes semantic
relationships within triplets from JSON documents through four stages:
triplet extraction, preprocessing, BERT embedding generation, and
similarity analysis. Evaluation on real datasets demonstrates over 83%
accuracy in extracting valid nested schema components. The study reveals
interdisciplinary intersections, using NLP to unveil structures in
scenarios lacking explicit schemas, showcasing significant potential for
autonomous schema extraction from raw, unstructured data formats.
Farmers’ perception on agricultural land degradation and their investments in farm land management technologies: implication for developing sustainable land management in Wolmera District, Central Ethiopia
Authors: Deche Almaz
Published: June 2024

Agricultural land degradation in most developing countries has become a
major constraint to future economic growth and development of rural
livelihoods. Thus, improving the livelihood of smallholder farmers
through the sustainable agricultural land management technologies can
protect and improve long-term agricultural land productivity and
habitats of all organisms including, human population. This study was
aimed to assess farmers’ perception on agricultural land degradation and
their investments in farm land management technologies and then it’s
implication for developing sustainable farmland management in Wolmera
District, Central Ethiopia. To achieve this open and close-ended
questionnaire were employed for 105 household heads and FGD and in-depth
interview with key informants were made. Data were analyzed in both
qualitative and quantitative methods. The result indicates that about
99% of farmers perceived soil erosion and fertility decline as the
major environmental problem in their cultivated land and its effect on
water resources (95%), loss of crop production (100%) and result in
increases the requirement of fertilizer (94%). Additionally, 80% of
the respondents believed that land degradation can be controlled.
Accordingly, crop rotation (100%), compost (20%) and animal manure
(40%) were recognized as they maintain soil fertility. While, Contour
plowing, Traditional ditches, Soil bund, Check dam, Cutoff drains and
Water way which accounts 96, 98, 93, 60, 52 and 96 use respectively to
prevented soil erosion Causes like deforestation, steep slope, over
cultivations and population growth, poor agricultural activity and
overgrazing were perceived by the most farmers as the main causes of
agricultural land degradation. Therefore attention should be given for
such factors, during preparation of promising agricultural land
management plan that considers suitability and adaptability to local
environmental conditions.
Model Reference Based Neural Controller for Transmission Line Inspection Robot
Authors: KARAGÖZ Zehra , EKREN Nazmi , ŞAHİN Mustafa , DEMİR Uğur , BABA Ahmet Fevzi
Published: June 2024

The regular inspection of the power transmission lines is essential for
the uninterrupted transmission of electrical energy to demand points.
This quickly requires actions with economically, efficiently, and
safely. Therefore, the transmission line inspection robots are
inevitable solution as an alternative to existing line inspection
methods. This study present design and control of a transmission line
inspection robot (I-Robot). Since the I-Robot exhibits nonlinear
behaviour and has multiple inputs and multiple outputs, a model
reference-based neural controller is determined to achieve nonlinear
control. The robot design process consists of 4 stages which are
kinematic modelling, dynamic modelling, actuator modelling and
controller design. To meet inspection requirements, the conceptual
design of the I-Robot is performed, and the kinematic model are
calculated in terms of the transformation matrices. According to the
design requirements and system constraints, the dynamic model of the
I-Robot is created. To provide desired motions and trajectory tracking,
the actuator models are determined. Then, the I-Robot is prototyped.
According to the dynamics of joint, robot and constraints, the system
identification is performed to create reference model. During the system
identification, the logged data are used the train the reference model.
Finally, the desired trajectory for the driving cycles is created by
manual excitation of the I-Robot. During the manual excitation, the
logged data are used to train the neural network-based controller.
Eventually, the I-Robot is assessed under the test scenarios in term of
the trajectory tracking performance as regression value and mean squared
errors.
Localized electrocortical activity as a function of single-leg squat phases and its relationship to knee frontal plane stability
Authors: Bonnette Scott , Wezenbeek Evi , Diekfuss Jed , Zuleger Taylor , Ramirez Mario , Sengkhammee Lexie , Raja Vicente , Myer Gregory , Riehm Christopher
Published: June 2024

This study investigated differences in electroencephalography (EEG)
activity within motor-related brain areas during three phases of a
single-leg squat (SLS)—i.e., descending, holding, and ascending
phases. Specifically, utilizing advanced magnetic resonance imaging
guided EEG source localization techniques and markerless motion capture
technology, we explored the interplay between concurrently recorded
lower-extremity biomechanics and brain activity. Among the phases of a
nondominant leg SLS, differences in contralateral brain activity (right
hemisphere) were found in the activity of the precentral gyrus, the
postcentral gyrus, and the sensory motor area. Alternatively, during the
dominant SLS leg, differences among the three SLS phases in
contralateral brain activity were fewer. Hemispheric dependent brain
activity also significantly correlated with participants’ knee valgus
angle range of motion (right hemisphere) and peak knee valgus angles
(left hemisphere). In addition to the novel brain and biomechanical
findings, this study sheds light on the technical feasibility of
recording EEG during complex multi-joint movements and its potential
applications in understanding sensorimotor behavior.
‘My face is listening to your smile’: Emotional contagion to vocal smile revealed by combined pupil reactivity and motor resonance.
Authors: Merchie Annabelle , Ranty Zoé , Hernandez Nadia , Aucouturier Jean-Julien , Wardak Claire , Gomot Marie
Published: June 2024

Interaction between the different components of emotional contagion
(i.e. emotional state and facial motor resonance), whether during
implicit or explicit appraisal of emotion remains controversial. The aim
of this study was i) to separate between these components thanks to
vocal smile processing and ii) to estimate how they reflect implicit
processes and/or an explicit appraisal loop. Emotional contagion to
discrete vocal emotions was studied in 25 adults, through motor
resonance and Autonomic Nervous System (ANS) reactivity. Facial
expressions (fEMG: facial electromyography) and pupil dilation were
assessed during processing and judgement of artificially emotionally
modified sentences. fEMG revealed that Zygomaticus major was reactive to
perceived sounds valence while Corrugator supercilii activity rather
reflected explicit judgement. Timing analysis of pupil dilation provided
further insight into both the emotional state and the implicit and
explicit processing of vocal emotion, showing an early activity for
emotional stimuli compared to neutral ones, followed by variations based
on sounds valence, and by a late additional increase of pupil diameter
depending on judgement. This innovative combination of these
electrophysiological measures shed new light on the debated central and
peripherical views within the framework of emotional contagion.
Improving cefazolin exposure in critically ill children using population pharmacokinetic model
Authors: Rivaud Clémence , Oualha Mehdi , salvador elodie , Bille Emmanuelle , Callot Delphine , beranger agathe , Froelicher Léo , Rouillon Steeve , Toubiana Julie , Benaboud Sihem , Renolleau Sylvain , Tréluyer Jean-Marc , Hirt Déborah , Cacqueray Noémie De
Published: June 2024

Aim: Population pharmacokinetics (PK) models may be effective to improve
antibiotic exposure with individualized dosing. The aim of the study is
to assess cefazolin exposure using a population PK model in critically
ill children. Methods: We conducted a single center observational study
including children under 18 years old who had cefazolin plasma
monitoring before and after the model implementation. First
concentration at steady state of each cefazolin course was analyzed.
Optimal exposure was defined by concentrations values ranged from free
concentration over 4 times the MIC for 100% of the dosing interval to
total trough or plateau concentration under 100 mg/L. Results:
Fifty-eight patients were included, of whom 39 and 19 children received
conventional dosing or model-informed dosing, respectively. Median
[range] age was 2.3 [0.1-17] years old and median weight was
14.2 [2.9-72] kg. There were more continuous infusions (CI) in the
model group than in the conventional group (n=19/19 (100%) vs n=23/39
(59%)). Compared to conventional dosing, model-informed dosing provided
more optimal exposure (n=17/39 (44%) vs n= 15/19 (79%), p=0.01) and
less underexposure (n= 18/39 (46%) vs n= 2/19 (10%), p=0.008), without
increasing overexposure (n= 4/39 (10%) vs n= 2/19 (11%), p=1).
Moreover, the time to reach a 50% decrease of C Reactive Protein levels
was significantly shorter in the model group than the conventional group
(3 [0.5-13] vs 4 [1-34]; p=0.045. Conclusions: Use of
individualized cefazolin model-informed dosing improves critically ill
children’s exposure. Further studies are needed to assess the clinical
benefit of cefazolin PK model application.
Population pharmacokinetics-pharmacodynamics-based dose optimization of carvedilol in patients following a gastric bypass surgery
Authors: Yamamoto Priscila , Vozmediano Valvanera , Cristofoletti Rodrigo , Jiang Jinmai , Schmittgen Thomas , Gaitani Cristiane de , Kemp Rafael , Sankarankutty Ajith , Santos Jose Sebastião dos , Jr Wilson Salgado , Moraes Natalia de
Published: June 2024

Aim: A population-based pharmacokinetic (PK) modeling approach (PopPK)
was used to investigate the impact of Roux-en-Y gastric bypass (RYGB) on
the PK of (R)- and (S)-carvedilol. We aimed to optimize carvedilol
dosing for these patients utilizing a pharmacokinetic/pharmacodynamic
(PK/PD) link model. Methods: PopPK models were developed utilizing data
from 52 subjects, including non-obese, obese, and post-RYGB patients who
received rac-carvedilol orally. Covariate analysis included
anthropometric and laboratory data, history of RYGB surgery, CYP2D6 and
CYP3A4 in vivo activity, and relative intestinal abundance of major
drug-metabolizing enzymes and transporters. A direct effect inhibitory
Emax pharmacodynamic model was linked to the PK model of (S)-carvedilol
to simulate the changes in exercise-induced heart rate. Results: A
two-compartmental model with linear elimination and parallel first-order
absorptions best described (S)-carvedilol PK. RYGB led to a twofold
reduction in relative oral bioavailability compared to non-operated
subjects, along with delayed absorption of both enantiomers. The
intestinal ABCC2 mRNA expression increases the time to reach the maximum
plasma concentration. The reduced exposure (AUC) of (S)-carvedilol
post-RYGB corresponded to a 33% decrease in the predicted area under
the effect curve (AUEC) for the 24-hour beta-blocker response.
Simulation results suggested that a 50 mg daily dose in post-RYGB
patients achieved comparable AUC and AUEC to 25 mg dose in non-operated
subjects. Conclusion: Integrated PK/PD modeling indicated that standard
dosage regimens for non-operated subjects do not provide equivalent
beta-blocking activity in RYGB patients. This study highlights the
importance of personalized dosing strategies to attain desired
therapeutic outcomes in this patient cohort.
University Teaching of Mass Spectrometry as a Key Practical Technique within the Context of a Fully-Integrated, Spiral Curriculum.
Authors: Worrall Andrew F. , Campbell Craig D. , Midson Megan O. , Stewart Malcolm I.
Published: June 2024

Rationale: Mass spectrometry (MS) is introduced to high school
students in the UK in many pre-university course syllabi. As such, we
have identified the use of MS as a key technique that should be taught
practically to undergraduates from the outset of their studies. This
mini‑review describes how we introduce and develop students’ use of MS
throughout our three‑year undergraduate spiral curriculum practical
program, using atmospheric pressure chemical ionisation MS (APCI/MS).
Methods: We have used an Advion Expression
spectrometer, fitted with an atmospheric solids analysis probe or a
Plate Express TLC sampler for sample introduction. Results: We
have successfully demonstrated the use of APCI-MS in a range of
practicals and experiments covering organic and organometallic
chemistries, with large cohorts of students gaining hands‑on
instrumental experience in authentic research settings.
Conclusions: APCI-MS has proven to be an easy-to-use and
valuable addition to our undergraduate practical course. The robustness
of the spectrometer enables routine use by large cohorts of students
with minimal supervision, and routine maintenance can be carried out by
non-specialist technicians. Students can readily process and interpret
results for a series of routine analyses, as well as demonstrate uses in
problem-solving exercises.
(Not) using private labels – the dilemma of independent aftermarket companies in Poland
Authors: Hys Katarzyna , Franke Alfred
Published: June 2024

In the present study, we discuss the role of private label (PL) in the context of the development of the independent automotive market (IAM) in Poland. We also seek to define a structural model for PLs, with regard to the IAM market in Poland. The article presents the results of the analysis of the literature on the subject as well as of interactive pilot research conducted among 80% of the IAM market in Poland. The research was conducted on 28 November 2013, during the 8th conference organised by the Association of Automotive Parts Distributors and Producers in Warsaw. In Poland, private labels are used most of all by trading companies. Independent aftermarket companies represent the sector of production and distribution. This difference is the result of decisions concerning the implementation of private labels in the automotive industry. Although the notion of private labels is known in the automotive industry there are barriers to introducing them nationally. The article presents the challenges and limitations of developing PL among Polish IAM entrepreneurs and proposes a PL strategy model. The overview and research results will allow IAM decision-makers to analyse the possibilities and threats that implementing private labels into their structures carries. As far as we know, the analysis and research presented here are among the first empirical explorations aimed at filling the IAM knowledge gap. Moreover, there is no comparative international research in this field, suggesting the need for further in-depth research. The analysis and research material makes the paper an original contribution to the development in this field.
Monte Carlo optimization based QSAR modeling of the cytotoxicity of acrylic acid-based dental monomers
Authors: Boskovic Mirjana , Stankovic Sasa , Zivkovic Jelena , Veselinovic Aleksandar
Published: June 2024

Acrylic acid derivatives are extensively utilized as initial monomers in dental materials. Nevertheless, these substances exhibit cytotoxicity towards different cell types, a phenomenon that must be reduced in future materials. The primary objective of this research is to establish a QSAR model for the prediction of cytotoxic effects and to identify molecular fragments and descriptors with mechanistic interpretations that play a role in cytotoxic effects. The Monte Carlo optimization technique employed QSAR models that are not reliant on conformation. These models utilized both molecular graph-based and SMILES-based descriptors. By employing a variety of statistical methodologies, an assessment of the predictive capabilities and resilience of the established QSAR models was achieved. The demonstrated numerical values used for their validation underscore the strong suitability of these QSAR models. The Monte Carlo optimization technique effectively identified molecular fragments represented in QSAR modeling through the use of SMILES notation, elucidating their impact on cytotoxicity, both positively and negatively. Given that the majority of molecular databases adhere to this molecular structure conformation, the featured QSAR models can serve as a rapid and precise screening tool for novel dental monomers.