bluuebunny/crossref_metadata_2025 huggingface dataset:
Aktueller Stand der Psychotherapie von Persönlichkeitsstörungen
Authors: Euler Sebastian , Stalujanis Esther , Spitzer Carsten
Published: March 2018

Zusammenfassung. Vor dem Hintergrund der epidemiologischen Bedeutung und den fortschreitenden Erkenntnissen zu biopsychosozialen Ätiopathogenesemodellen fokussiert diese Arbeit auf den aktuellen Stand der Psychotherapie von Persönlichkeitsstörungen als Behandlungsmethode der Wahl. Der Schwerpunkt wird dabei auf die Borderline-, antisoziale, narzisstische und ängstlich-vermeidende Persönlichkeitsstörung gelegt. Gerade für die Borderline-Persönlichkeitsstörung (BPS) als klinisch bedeutsamste Persönlichkeitsstörung sind verschiedene schulenübergreifende, transtheoretische Therapieansätze entwickelt und hinsichtlich ihrer Wirksamkeit mit guten Ergebnissen empirisch überprüft worden. Zu diesen evidenzbasierten Behandlungsverfahren zählen die Dialektisch-Behaviorale Therapie (DBT), die Mentalisierungsbasierte Therapie (MBT), die Übertragungsfokussierte Therapie (TFP) und die Schematherapie (ST), die alle in allgemeinen Grundprinzipien konvergieren. Auch für die antisoziale, narzisstische und ängstlich-vermeidende Persönlichkeitsstörung können allgemeine Behandlungsprinzipien formuliert werden, die den jeweiligen Besonderheiten der Störungsbilder Rechnung tragen; allerdings liegen diesbezüglich weniger Hinweise auf die Wirksamkeitsevidenz von Psychotherapie vor als bei der BPS. Abschließend werden zukünftige Herausforderungen für die Psychotherapie(-forschung) diskutiert.
AGU Endorses the 2018 March for Science
Authors: McEntee Chris
Published: March 2018

The American Geophysical Union is offering financial and in-kind support to help our members take part in marches locally. Apply by 26 March.
In situ fabrication of silver-based nanostructures using electron beam
Authors: Ma Cuncheng , Chen Xiangru , Tan Xiaohua , Hu Pengfei , Li Qiang , Cao Yali , Liang Xue
Published: March 2018

The electron beam was employed to in situ fabricate the Ag-based nanostructures with controllable microstructure and composition.
Theory for controlling individual self-propelled micro-swimmers by photon nudging I: directed transport
Authors: Selmke Markus , Khadka Utsab , Bregulla Andreas P. , Cichos Frank , Yang Haw
Published: March 2018

Photon nudging is a new experimental method which enables the force-free manipulation and localization of individual self-propelled artificial micro-swimmers in fluidic environments.
Rheology of phosphonium ionic liquids: a molecular dynamics and experimental study
Authors: Sarman Sten , Wang Yong-Lei , Rohlmann Patrick , Glavatskih Sergei , Laaksonen Aatto
Published: March 2018

Comparison between the theoretical and experimental viscosity of an ionic liquid.
Field-cycling NMR experiments in an ultra-wide magnetic field range: relaxation and coherent polarization transfer
Authors: Zhukov Ivan V. , Kiryutin Alexey S. , Yurkovskaya Alexandra V. , Grishin Yuri A. , Vieth Hans-Martin , Ivanov Konstantin L.
Published: March 2018

An experimental method is described allowing fast field-cycling Nuclear Magnetic Resonance (NMR) experiments over a wide range of magnetic fields from 5 nT to 10 T.
Nanocellulose: a promising nanomaterial for advanced electrochemical energy storage
Authors: Chen Wenshuai , Yu Haipeng , Lee Sang-Young , Wei Tong , Li Jian , Fan Zhuangjun
Published: March 2018

Nanocellulose from various kinds of sources and nanocellulose-derived materials have been developed for electrochemical energy storage, including supercapacitors, lithium-ion batteries, lithium–sulfur batteries, and sodium-ion batteries.
A novel method for source-specific hemoglobin adducts of nitro-polycyclic aromatic hydrocarbons
Authors: Wheelock Kylie , Zhang Junfeng (Jim) , McConnell Rob , Tang Deliang , Volk Heather E. , Wang Ya , Herbstman Julie B. , Wang Shuang , Phillips David H. , Camann David , Gong Jicheng , Perera Frederica
Published: March 2018

Polycyclic aromatic hydrocarbons (PAH) are ubiquitous air pollutants associated with negative impacts on growth, development and behavior in children.
Graphene-based ordered mesoporous carbon hybrids with large surface areas for supercapacitors
Authors: Deng Yun , Xu Aifei , Lu Wangting , Yu Yanhua , Fu Cheng , Shu Tingting
Published: March 2018

Graphene-ordered mesoporous carbon hybrids exhibited advanced specific capacity, high energy density and power density, and long cycle life.
Nitrogen-doped carbon dots for the detection of mercury ions in living cells and visualization of latent fingerprints
Authors: Ren Guojuan , Meng Yuxi , Zhang Qi , Tang Mingyu , Zhu Baoya , Chai Fang , Wang Chungang , Su Zhongmin
Published: March 2018

Nitrogen-doped carbon dots (NCDs) were synthesised using a simple and straightforward solvothermal method.
Real-time monitoring of the Trojan-horse effect of silver nanoparticles by using a genetically encoded fluorescent cell sensor
Authors: You Fang , Tang Wenqin , Yung Lin-Yue Lanry
Published: March 2018

A genetically encoded fluorescent protein sensor enabled monitoring the “Trojan-horse” type cytotoxicity of silver nanoparticles.
Preparation of lactic acid- and glucose-responsive poly(ε-caprolactone)-b-poly(ethylene oxide) block copolymer micelles using phenylboronic ester as a sensitive block linkage
Authors: Vrbata David , Uchman Mariusz
Published: March 2018

The present study describes the synthesis, self-assembly and responsiveness to glucose and lactic acid of biocompatible and biodegradable block copolymer micelles using phenylboronic ester as the linkage between hydrophobic PCL and hydrophilic PEO blocks.
Highly enhanced response of MoS2/porous silicon nanowire heterojunctions to NO2 at room temperature
Authors: Zhao Shufen , Li Zhengcao , Wang Guojing , Liao Jiecui , Lv Shasha , Zhu Zhenan
Published: March 2018

Molybdenum disulfide/porous silicon nanowire (MoS2/PSiNW) heterojunctions with different thicknesses as highly-responsive NO2 gas sensors were obtained in the present study.
An impedimetric determination of alkaline phosphatase activity based on the oxidation reaction mediated by Cu2+ bound to poly-thymine DNA
Authors: Lee Joon Young , Ahn Jun Ki , Park Ki Soo , Park Hyun Gyu
Published: March 2018

A novel impedimetric assay for the accurate determination of alkaline phosphatase (ALP) activity is developed based on the Cu2+-mediated oxidation of ascorbic acid on a poly-thymine DNA-modified electrode.
Enhancement of the thermoelectric properties of PEDOT:PSS via one-step treatment with cosolvents or their solutions of organic salts
Authors: Zhang Siyao , Fan Zeng , Wang Xinwei , Zhang Zhongyin , Ouyang Jianyong
Published: March 2018

A power factor of 144 μW m−1 K−2 has been successfully achieved for PEDOT:PSS via a one-step treatment with cosolvent solution.
Development and validation of a stability-indicating ultra-performance liquid chromatography (UPLC) method for doxycycline hyclate: an optimization of the analytical methodology for a medical countermeasure (MCM) drug
Authors: Mohammad Adil , Yen Cheng H. , Schneider Miah , Lowry Bryan , Yerlikaya Firat , Whitesell Gretchen , Leisssa Brad , Faustino Patrick J. , Khan Saeed R.
Published: March 2018

Doxycycline hyclate drug product impurities and rapid quantification using a validated UPLC method.
A pilot study in humans of microneedle sensor arrays for continuous glucose monitoring
Authors: Sharma Sanjiv , El-Laboudi Ahmed , Reddy Monika , Jugnee Narvada , Sivasubramaniyam Sujan , El Sharkawy Mohamed , Georgiou Pantelis , Johnston Desmond , Oliver Nick , Cass Anthony E. G.
Published: March 2018

Although subcutaneously implanted continuous glucose monitoring (CGM) devices have been shown to support diabetes self-management, their uptake remains low due to high costs and poor accuracy and precision arising from their invasiveness.
An organic–inorganic hybrid zinc phosphite framework with room temperature phosphorescence
Authors: Ni Ai-Yun , Mu Ying , Pan Jie , Han Song-De , Shang Meng-Meng , Wang Guo-Ming
Published: March 2018

An organic–inorganic hybrid zinc phosphite framework with large channels and fascinating room temperature phosphorescence has been presented.
A thermo-responsive structural switch and colossal anisotropic thermal expansion in a chiral organic solid
Authors: Janiak Agnieszka , Esterhuysen Catharine , Barbour Leonard J.
Published: March 2018

The apohost form of a chiral trianglimine compound exists in at least three polymorphic forms. Despite similar packing arrangements, only two of these forms exhibit anomalous thermal expansion behaviour, and undergo thermally-induced interconversion.
Insight into the crystal phase and shape evolution from monoclinic Cu1.94S to wurtzite Cu2ZnSnS4 nanocrystals
Authors: Zhang Xiaoyan , Xu You , Pang Chao , Wang Yifeng , Shen Liming , Gupta Arunava , Bao Ningzhong
Published: March 2018

The Sn content greatly influences the morphology of CZTS NCs when using Cu1.94S nanoplates as starting materials.
Core–shell hierarchical C@Na2Ti3O7·9H2O nanostructures for the efficient removal of radionuclides
Authors: Tan Xiaoli , Fang Ming , Tan Liqiang , Liu Haining , Ye Xiushen , Hayat Tasawar , Wang Xiangke
Published: March 2018

Hierarchical C@Na2Ti3O7·9H2O nanostructures were fabricated and showed high adsorption properties to radionuclides.
Ultrasmall fluorescent nanoparticles derived from roast duck: their physicochemical characteristics and interaction with human serum albumin
Authors: Cong Shuang , Bi Jingran , Song Xunyu , Yu Chenxu , Tan Mingqian
Published: March 2018

Fluorescent nanoparticles (FNPs) produced from roast meat have drawn widespread attention due to their potential hazards to human health.
Production of monosaccharides and whey protein from acid whey waste streams in the dairy industry
Authors: Lindsay Mark J. , Walker Theodore W. , Dumesic James A. , Rankin Scott A. , Huber George W.
Published: March 2018

A kinetic model is developed for acid-catalyzed lactose hydrolysis, and filtration improves the lactose hydrolysis rate and monosaccharide selectivity in acid whey.
Toward non-volatile photonic memory: concept, material and design
Authors: Zhai Yongbiao , Yang Jia-Qin , Zhou Ye , Mao Jing-Yu , Ren Yi , Roy Vellaisamy A. L. , Han Su-Ting
Published: March 2018

This review presents the development of photonic memory, with a view towards inspiring more intriguing ideas on the elegant selection of materials and design of novel device structures that may finally induce major progress in the fabrication and application of photonic memory.
Conducting photopolymers on orthopeadic implants having a switch of priority between promoting osteogenic and antibacterial activity
Authors: Liao Jingwen , Chen Weiguo , Yang Mingjin , Zhou Junli , Wang Zhengao , Zhou Yahong , Ning Chengyun , Yuan Hai
Published: March 2018

Photopolymerized polymers with functional incorporation deliver a switch of priority between promoting osteogenic and antibacterial activity of implants.
Label-free detection of β-amyloid peptides (Aβ40 and Aβ42): a colorimetric sensor array for plasma monitoring of Alzheimer's disease
Authors: Ghasemi Forough , Hormozi-Nezhad M. Reza , Mahmoudi Morteza
Published: March 2018

A nanoparticle-based colorimetric sensor array for identification of structurally similar Aβ peptides (Aβ40 and Aβ42) for monitoring of Alzheimer's disease at early stages.
Diamond nanothread based resonators: ultrahigh sensitivity and low dissipation
Authors: Duan Ke , Li Yijun , Li Li , Hu Yujin , Wang Xuelin
Published: March 2018

Diamond nanothreads exhibit ultrahigh mass sensitivity and low intrinsic dissipation and have huge potential in sensing applications.
In situ synthesis of metal clusters encapsulated within small-pore zeolites via a dry gel conversion method
Authors: Yang Xiaoli , Liu Qinggang , Zhang Yaru , Su Xiong , Huang Yanqiang , Zhang Tao
Published: March 2018

We report here a facile strategy for encapsulating Pt clusters into MFI crystals via a dry gel conversion (DGC) method, by introducing Pt-immobilized Schiff-SiO2 as the silicon resource.
Quantum oscillation in carrier transport in two-dimensional junctions
Authors: Zhang Junfeng , Xie Weiyu , Agiorgousis Michael L. , Choe Duk-Hyun , Meunier Vincent , Xu Xiaohong , Zhao Jijun , Zhang Shengbai
Published: March 2018

Typical structures of two-electrode devices in 2D junction and the corresponding transmission coefficients with the function of bilayer length.
Multiroom-structured multicomponent metal selenide–graphitic carbon–carbon nanotube hybrid microspheres as efficient anode materials for sodium-ion batteries
Authors: Park Gi Dae , Kang Yun Chan
Published: March 2018

Novel 3D multiroom-structured multicomponent metal (NiFe) selenide–graphitic carbon–carbon nanotube hybrid microspheres showing excellent performances for sodium-ion storage were prepared by spray pyrolysis and a subsequent selenization process.
Correction: A high quality liquid-type quantum dot white light-emitting diode
Authors: Sher Chin-Wei , Lin Chih-Hao , Lin Huang-Yu , Lin Chien-Chung , Huang Che-Hsuan , Chen Kuo-Ju , Li Jie-Ru , Wang Kuan-Yu , Tu Hsien-Hao , Fu Chien-Chung , Kuo Hao-Chung
Published: March 2018

Correction for ‘A high quality liquid-type quantum dot white light-emitting diode’ by Chin-Wei Sher et al., Nanoscale, 2016, 8, 1117–1122.
Gold(i)-catalyzed cross-coupling reactions of aryldiazonium salts with organostannanes
Authors: Akram Manjur O. , Shinde Popat S. , Chintawar Chetan C. , Patil Nitin T.
Published: March 2018

Gold(i)-catalyzed cross-coupling reactions of aryldiazonium salts with organostannanes are described.
An efficient approach to 4-chloro quinolines via TMSCl-mediated cascade cyclization of ortho-propynol phenyl azides
Authors: Song Xian-Rong , Li Ren , Ding Haixin , Chen Xi , Yang Tao , Bai Jiang , Xiao Qiang , Liang Yong-Min
Published: March 2018

A novel and efficient strategy for the synthesis of 4-chloro quinolines via the TMSCl-mediated cascade cyclization of easily prepared ortho-propynol phenyl azides is developed.
Divergent reactions of oxindoles with amino alcohols via the borrowing hydrogen process: oxindole ring opening vs. C3 alkylation
Authors: Di Gregorio Giovanni , Mari Michele , Bartolucci Silvia , Bartoccini Francesca , Piersanti Giovanni
Published: March 2018

Oxindoles react with N-acetyl amino alcohols to form tryptamine-derived oxindoles, whereas analogous reactions with N-alkyl amino alcohols lead to lactam formation via a relatively mild borrowing hydrogen process.
Alginate based antimicrobial hydrogels formed by integrating Diels–Alder “click chemistry” and the thiol–ene reaction
Authors: Wang Gang , Zhu Jiehua , Chen Xiaofeng , Dong Hua , Li Qingtao , Zeng Lei , Cao Xiaodong
Published: March 2018

In recent years medical devices manufacturers have been looking for antimicrobial coatings which are biocompatible and non-toxic for a wide range of medical devices.
Identification of a new series of benzothiazinone derivatives with excellent antitubercular activity and improved pharmacokinetic profiles
Authors: Xiong Lu , Gao Chao , Shi Yao-Jie , Tao Xin , Rong Juan , Liu Kun-Lin , Peng Cui-Ting , Wang Ning-Yu , Lei Qian , Zhang Yi-Wen , Yu Luo-Ting , Wei Yu-Quan
Published: March 2018

Nitrobenzothiazinone (BTZ) is a promising scaffold with potent activity against M. tuberculosis by inhibiting decaprenylphosphoryl-beta-d-ribose 2′-oxidase (DprE1).
Ultrasensitive and bifunctional ZnO nanoplates for an oxidative electrochemical and chemical sensor of NO2: implications towards environmental monitoring of the nitrite reaction
Authors: Mali Shivsharan M. , Chavan Parag P. , Navale Yuvraj H. , Patil Vikas B. , Sathe Bhaskar R.
Published: March 2018

Herein, we focused on the one pot synthesis of ZnO nanoplates (NP edge thickness of ∼100 nm) using a chemical emulsion approach for chemical (direct) and electrochemical (indirect) determination of NO2.
Formal total synthesis of histrionicotoxin alkaloids via Hg(OTf)2-catalyzed cycloisomerization and SmI2-induced ring expansion
Authors: Matsumura Kunihiro , Nishikawa Keisuke , Yoshida Hiroaki , Doe Matsumi , Morimoto Yoshiki
Published: March 2018

The efficient formal total synthesis of histrionicotoxin alkaloids was achieved via Hg(OTf)2-catalyzed cycloisomerization and SmI2-induced ring expansion.
Correction: Luminescence properties of the pink emitting persistent phosphor Pr3+-doped La3GaGe5O16
Authors: Zhang Shaoan , Hu Yihua , Chen Li , Ju GuiFang , Wang Tao , Wang Zhonghua
Published: March 2018

Correction for ‘Luminescence properties of the pink emitting persistent phosphor Pr3+-doped La3GaGe5O16’ by Shaoan Zhang et al., RSC Adv., 2015, 5, 37172–37179.
A definitive assessment of the CO oxidation pattern of a nanocomposite MnCeOx catalyst
Authors: Arena Francesco , di Chio Roberto , Espro Claudia , Palella Alessandra , Spadaro Lorenzo
Published: March 2018

A concerted redox mechanism of L–H type predicts the CO oxidation pattern of nanocomposite MnCeOx catalysts in the range of 293–533 K.
Precise control of pore hydrophilicity enabled by post-synthetic cation exchange in metal–organic frameworks
Authors: Wright Ashley M. , Rieth Adam J. , Yang Sungwoo , Wang Evelyn N. , Dincă Mircea
Published: March 2018

The ability to control the relative humidity at which water uptake occurs in a given adsorbent is advantageous, making that material applicable to a variety of different applications.
Composition-adjustable Ag–Au substitutional alloy microcages enabling tunable plasmon resonance for ultrasensitive SERS
Authors: Wang Xiaotian , Ma Guanshui , Li Anran , Yu Jian , Yang Zhao , Lin Jie , Li Ang , Han Xiaodong , Guo Lin
Published: March 2018

A facile NaBH4-cooperative GRR strategy generating composition-adjustable Ag–Au substitutional alloy microcages enabling tunable plasmon resonance for ultrasensitive SERS.
Three-dimensional carbon/ZnO nanomembrane foam as an anode for lithium-ion battery with long-life and high areal capacity
Authors: Zhao Yuting , Huang Gaoshan , Li Yalan , Edy Riyanto , Gao Peibo , Tang Huang , Bao Zhihao , Mei Yongfeng
Published: March 2018

A 3D carbon/ZnO nanomembrane foam anode with practical ZnO loading leads to high areal capacity and long term stability.
Oxygen vacancies on the surface of HxWO3−y for enhanced charge storage
Authors: Wang Haiyan , Fan Ruxue , Miao Jingyu , Chen Jiayi , Mao Shanjun , Deng Jiang , Wang Yong
Published: March 2018

The dominant role of surface oxygen vacancies (OVs) in improving energy storage is underscored by comparing the OV-mediated charge storage performance of surface and bulk defective HxWO3−y with that of WO3 and bulk defective e-HxWO3−y.
Nonflammable superhydrophobic paper with biomimetic layered structure exhibiting boiling-water resistance and repairable properties for emulsion separation
Authors: Wen Gang , Guo ZhiGuang
Published: March 2018

A superior, fire-resistant and repairable superhydrophobic PFDS-paper@ZnO that exhibits remarkable oil absorption–combustion performance is prepared. In addition, the burnt paper with underwater superoleophobic property can be used for efficiently surfactant-stabilized oil-in-water emulsion separation.
Ties that bind: the integration of plastid signalling pathways in plant cell metabolism
Authors: Brunkard Jacob O. , Burch-Smith Tessa M.
Published: March 2018

Plastids are critical organelles in plant cells that perform diverse functions and are central to many metabolic pathways. Beyond their major roles in primary metabolism, of which their role in photosynthesis is perhaps best known, plastids contribute to the biosynthesis of phytohormones and other secondary metabolites, store critical biomolecules, and sense a range of environmental stresses. Accordingly, plastid-derived signals coordinate a host of physiological and developmental processes, often by emitting signalling molecules that regulate the expression of nuclear genes. Several excellent recent reviews have provided broad perspectives on plastid signalling pathways. In this review, we will highlight recent advances in our understanding of chloroplast signalling pathways. Our discussion focuses on new discoveries illuminating how chloroplasts determine life and death decisions in cells and on studies elucidating tetrapyrrole biosynthesis signal transduction networks. We will also examine the role of a plastid RNA helicase, ISE2, in chloroplast signalling, and scrutinize intriguing results investigating the potential role of stromules in conducting signals from the chloroplast to other cellular locations.
Approximation of fracture energies withp-growthviapiecewise affine finite elements
Authors: Conti Sergio , Focardi Matteo , Iurlano Flaviana
Published: March 2018

The modeling of fracture problems within geometrically linear elasticity is often based on the space of generalized functions of bounded deformationGSBDp(Ω),p∈ (1,∞), their treatment is however hindered by the very low regularity of those functions and by the lack of appropriate density results. We construct here an approximation ofGSBDpfunctions, forp∈ (1,∞), with functions which are Lipschitz continuous away from a jump set which is a finite union of closed subsets ofC1hypersurfaces. The strains of the approximating functions converge strongly inLpto the strain of the target, and the area of their jump sets converge to the area of the target. The key idea is to use piecewise affine functions on a suitable grid, which is obtainedviathe Freudenthal partition of a cubic grid.
Apports lipidiques pendant la période périnatale ; relation avec l’obésité de l’enfant et du futur adulte
Authors: Rolland-Cachera Marie Françoise
Published: March 2018

Après une augmentation rapide suivie d’une stabilisation, l’obésité infantile reste élevée dans un grand nombre de pays. L’évolution des apports nutritionnels explique difficilement l’épidémie d’obésité, puisque lorsque l’obésité augmentait, les apports caloriques et lipidiques diminuaient. L’alimentation au début de la vie peut expliquer ce paradoxe. Il est maintenant bien établi que des facteurs environnementaux agissant au début de la vie auront des conséquences sur la santé à long terme (période des « 1000 premiers jours »). Le rebond d’adiposité précoce relevé chez la plupart des obèses suggère une telle programmation. Des apports élevés en protéines et faibles en lipides sont relevés chez les enfants de nombreux pays industrialisés. Ce déséquilibre est très éloigné de la composition du lait maternel, ainsi que des recommandations officielles indiquant que les lipides ne devaient pas être restreints avant l’âge de 3 ans. Des hypothèses sont proposées pour expliquer l’association entre faibles apports en lipides et obésité. En particulier, la restriction des lipides au début de la vie pourrait programmer un métabolisme adapté aux apports insuffisants (« métabolisme économe »), devenant néfaste lorsque les apports augmenteront (« mismatch »). Ces observations soulignent l’importance d’adapter les apports nutritionnels aux besoins spécifiques à chaque étape de la croissance.
On the rate of convergence in the central limit theorem for hierarchical Laplacians
Authors: Bendikov Alexander , Cygan Wojciech
Published: March 2018

Let (X,d) be a proper ultrametric space. Given a measuremonXand a functionB↦C(B) defined on the set of all non-singleton ballsBwe consider the hierarchical LaplacianL=LC. Choosing a sequence {ε(B)} of i.i.d. random variables we define the perturbed functionC(B,ω) and the perturbed hierarchical LaplacianLω=LC(ω). We study the arithmetic means λ̅(ω) of theLω-eigenvalues. Under certain assumptions the normalized arithmetic means (λ̅−Eλ̅) ∕ σ(λ̅) converge in law to the standard normal distribution. In this note we study convergence in the total variation distance and estimate the rate of convergence.
The effect of corticosteroid versus platelet-rich plasma injection therapies for the management of lateral epicondylitis: A systematic review
Authors: Ben-Nafa Walid , Munro Wendy
Published: March 2018

Introduction: Lateral epicondylitis is a common musculoskeletal disorder of the upper limb. Corticosteroid injection has been widely used as a major mode of treatment. However, better understanding of the pathophysiology of the disease led to a major change in treating the disease, with new options including platelet-rich plasma (PRP) are currently used.

Objectives/research aim: To systematically evaluate the effect of corticosteroid versus PRP injections for the treatment of LE.

Hypothesis: PRP injections provide longer-term therapeutic effect and less rate of complications compared to corticosteroid injection.

Level of evidence: Level 2 evidence (4 included studies are of level 1 evidence, 1 study of level 2 evidence).

Design: Systematic Review (according to PRISMA guidelines).

Methods: Eleven databases used to search for relevant primary studies comparing the effects of corticosteroid and PRP injections for the treatment of LE. Quality appraisal of studies performed using Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0, CASP Randomised Controlled Trial Checklist, and SIGN Methodology Checklist 2.

Results: 732 papers were identified. Five randomised controlled trials (250 Patients) met the inclusion criteria.Clinical findings: Corticosteroid injections provided rapid symptomatic improvement with maximum effect at 6/8/8 weeks before symptoms recurrence, whereas PRP showed slower ongoing improvements up to 24/52/104 weeks(3 studies). Corticosteroid showed more rapid symptomatic improvement of symptoms compared to PRP up to the study end-point of 3 months(1 study). Comparable therapeutic effects of corticosteroid and PRP were observed at 6 weeks(1 study).Ultrasonographic Findings: (1) Doppler activity decreased more significantly in patients who received corticosteroid compared to PRP. (2) Reduced tendon thickness and more patients with cortical erosion noted in corticosteroid group whereas increased tendon thickness and less number of patients with common extensor tendon tears noted in PRP group. (3) Fewer patients reported Probe-induced tenderness and oedema in the common extensor tendon in both corticosteroid and PRP groups (2 studies).

Conclusion: Corticosteroid injections provide rapid therapeutic effect in the short-term with recurrence of symptoms afterwards, compared to the relatively slower but longer-term effect of platelet-rich plasma.
Paraneoplastische erosive Arthritis, Rheumafaktor- und Anti-CCP-positiv, bei B-Zell-Lymphom
Authors: Matveev I. , Hartig I. , Braun M.
Published: March 2018

Wir berichten von einem 73-jährigen Patienten, der sich mit einer symmetrischen poly artikulären Arthritis, primär die MCPund MTP-Gelenke betreffend, vorstellte. Serologisch erhöhtes CRP und Nachweis eines Anti-CCP-Antikörpers und Rheumafaktors. Radiologisch zeigten sich zystisch erosive Veränderungen an den MCP- und MTP-Gelenken. Eine rheumatoide Arthritis wurde diagnostiziert und eine Basistherapie mit MTX, begleitend Prednisolon, eingeleitet. Im Verlauf traten Schmerzen der distalen Tibia auf, in der Knochenszintigrafie zeigte sich eine Mehr belegung, in der CT fiel eine zystisch destruierende Läsion auf. Die Histologie dieser Läsion ergab eine Infiltration eines CD20+-B-Zell-Lymphoms. Paraneoplastische Syndrome müssen immer differenzialdiagnostisch bei neu auftretenden Arthritiden erwogen werden. Die differenzialdiagnostischen Erwägungen paraneoplastischer Syndrome mit Arthritiden werden diskutiert.
Das Laufverhalten von Patienten mit künstlichem Hüftgelenkersatz und dessen Folgeerscheinungen: Ein systematisches Review zum aktuellen Forschungsstand
Authors: Pohl T. , Horstmann T. , Perschke S.
Published: March 2018

Laufen wird als Sportart mit hoher Stoßbelastung eingestuft und Patienten mit einem künstlichen Hüftgelenk nicht empfohlen. Entgegen dieser Empfehlungen kehren einige Läufer nach einer Operation dennoch zum Laufsport zurück. Es sind wissenschaftliche Erkenntnisse zum allgemeinen postoperativen Sportverhalten vorhanden, allerdings kaum Ergebnisse zum Laufen im Speziellen. Auf Basis der aktuellen Datenlage soll dieses Review die Fragen bearbeiten, (1) wie hoch der Läuferanteil unter den Patienten ist, (2) welche Trainingsparameter festzustellen sind und (3) ob negative Folgeerscheinungen für die Prothesenhaltbarkeit auftreten. In PubMed wurde mit einer spezifischen MeSH-Term-Suche gearbeitet. Nach der Analyse von Titel, Abstract und Volltext erfüllten drei von ursprünglich 39 Artikeln die Einschlusskriterien. Postoperativ betrug der Anteil an joggenden Patienten zwischen 3,8 % und 16,3 %. Nur zwei der Studien berichteten von Trainingsparametern: Die wöchentliche Trainingsfrequenz lag bei 3,5–4-Mal pro Woche mit Läufen zwischen 14,4–28,4 km, 116–186 Minuten und 7,7–9,2 km/h. Ein Patient nahm sogar an einem Marathon über 42,5 km teil. In der eingeschlossenen Literatur wurde in keinem Fall von Prothesenlockerung oder erhöhter Abnutzung berichtet. Positiv ist, dass die Läufer eine bessere körperliche Funktion und weniger Schmerzen zeigten als nicht laufende Hüftprothesen-Patienten. Es bleibt zu beachten, dass die eingeschlossene Literatur keine ausreichende Evidenz über Langzeiteffekte auf Hüftgelenkersatz durch Laufen liefert. Erstens ist die Anzahl an Studien mit hoher Qualität gering und zweitens lagen die beobachteten Follow-Up-Längen bei 3,9 Jahren und sind folglich unzulänglich kurz. Neben Longitudinalstudien würde eine biomechanische Untersuchung helfen, die Empfehlungen zum Laufen nach Hüftgelenkersatz weiterzuentwickeln.
Risk of Venous Thromboembolism Recurrence: High Negative Predictive Value of D-dimer Performed after Oral Anticoagulation Is Stopped
Authors: Legnani Cristina , Cosmi Benilde , Guazzaloca Giuliana , Pancani Claudia , Coccheri Sergio , Palareti Gualtiero
Published: March 2018

In some patients with previous venous thromboembolism (VTE) D-dimer levels (D-Dimer) tend to increase after oral anticoagulant therapy (OAT) is stopped. The aim of our study was to evaluate the predictive value of D-Dimer for the risk of VTE recurrence after OAT withdrawal. After a first episode of deep vein thrombosis (DVT) of the lower limbs and/or pulmonary embolism (PE), 396 patients (median age 67 years, 198 males) were followed from the day of OAT discontinuation for 21 months. D-dimer was measured on the day of OAT withdrawal (T1), 3-4 weeks (T2) and 3 months (+/− 10 days, T3) thereafter. The main outcome events of the study were: objectively documented recurrent DVT and/or PE. D-dimer was found to be increased in 15.5%, 40.3% and 46.2% of the patients at T1, T2 and T3, respectively. In 199 (50.2%) patients, D-dimer levels were elevated in at least one measurement. During a follow-up of 628.4 years, 40 recurrences were recorded (10.1% of patients; 6.4% patient-years of follow-up). D-dimer was increased in at least one measurement in 28 of these cases, but remained normal in 11 subjects (three of whom had recurrent events triggered by circumstantial factors, three with malignancyassociated factors) (in one subject D-dimer was not measured). The negative predictive value (NPV) of D-dimer was 95.6% (95% CI 91.6-98.1) at T3 and was even higher (96.7%; 95% CI 92.9-98.8) after exclusion of the six recurrences due to circumstantial factors. Only five idiopathic recurrences occurred in the 186 patients with consistently normal D-dimer. In conclusion, D-dimer has a high NPV for VTE recurrence when performed after OAT discontinuation.
FV HR2 Haplotype as Additional Inherited Risk Factor for Deep Vein Thrombosis in Individuals with a High-Risk Profile
Authors: Bossone Anna , Coalizzo Donatella , D’Andrea Giovanna , Brancaccio Vincenzo , Ciampa Antonio , Grandone Elvira , Di Minno Giovanni , Margaglione Maurizio
Published: March 2018

A number of strongly linked polymorphisms within the Factor V gene (FV HR2 haplotype) has been identified as a cause of resistance to activated protein C, and has suggested a modest risk factor for vein thrombosis. We investigated the frequency of the HR2 haplotype in 433 consecutive patients with confirmed deep vein thrombosis and 326 controls. The HR2 haplotype was more frequent in patients (15.2%) than in controls (10.1%). The risk of thrombosis among carriers of this haplotype was significantly increased (odds ratio: 1.6 [95% CI: 1.0-2.5]). The estimated risk associated with the HR2 haplotype was 1.8 (95% CI: 1.1-2.9) in subjects with (n = 255), and 1.4 (95% CI: 0.8-2.4) in those without (n = 178) acquired risk factors for vein thrombosis. After adjustment for sex, FV Leiden and FII A20210 mutations, the estimated risk of vein thrombosis among carriers of the HR2 haplotype was 1.8 (95% CI: 1.1-2.8). Present data indicate that the HR2 haplotype is independently associated with vein thrombosis among individuals with a highrisk profile.
Plasma Protein Oxidation Is Associated with an Increase of Procoagulant Markers Causing an Imbalance between Pro- and Anticoagulant Pathways in Healthy Subjects
Authors: Rocca Bianca , Marchioli Roberto , Landolfi Raffaele , De Cristofaro Raimondo
Published: March 2018

The aim of the present study was to investigate whether the overall oxidation state of plasma proteins is associated with changes of circulating pro- and anticoagulant markers in healthy subjects (n = 99, 49 males, 50 females, aged from 6 to 91 yrs.). The carbonyl content of plasma proteins was measured and validated as an ex vivo index of the overall protein oxidation state due to its correlation with the plasma level of o-tyrosine (r = 0.87, P <0.0001), which is a well known oxidized product of L-phenylalanine. Using a multivariate analysis the carbonyl content of plasma protein was positively associated with procoagulant markers such as prothrombin F1 + 2 (r = 0.28, P = 0.0019) and fibrinopeptide A, (FpA) (r = 0.278, P = 0.003), as well as with the soluble derivative of the endothelial protein thrombomodulin (TM) (r = 0.469, P <0.0001). The procoagulant marker of thrombin activity, FpA, was significantly and positively correlated with the anticoagulant product of thrombin, namely the Protein C activation peptide (PCP), only in the tertile with low protein carbonyl content. At higher tertiles this correlation was no longer observed, thus suggesting a detrimental effect of oxidative stress on the TM/Protein C anticoagulant pathway. In 15 subjects with high carbonyl content of plasma protein, treatment for 18 days with 600 mg/d of vitamin E did not substantially modify the protein carbonyl content, the anticoagulant markers APC/PCP, and all procoagulant markers except F1+2, whose value significantly decreased by 25%.

In conclusion, the present study shows that a high plasma protein oxidation ex vivo is associated with an overall hemostatic imbalance, which favors procoagulant markers. Vitamin E treatment in vivo restores only in part the equilibrium between pro- and anticoagulant pathways. This may open the way to further studies aimed at elucidating the mechanisms by which the oxidative stress is linked to activation of the coagulation system in atherothrombotic disorders.

Abbreviations: APC: activated Protein C; F1+2: prothrombin fragment 1+2; FpA: fibrinopeptide A; PCP: Protein C activation peptide; TM: thrombomodulin
Evaluation of Frozen Plasma Calibrants for Enhanced Standardization of the International Normalized Ratio (INR): A Multi-Center Study
Authors: Johnston Marilyn , Adcock Dorothy
Published: March 2018

Local ISI calibration has been proposed to improve INR accuracy and inter-laboratory precision. We evaluated the affect of local PT calibration on INR precision and accuracy using six levels of frozen plasma calibrants prepared and pooled from normal donors and patients stabilized on sodium warfarin (coumarin) based oral anticoagulant therapy (OAT). Reference prothrombin time (PT) and INR values were assigned to these calibrants in accordance with World Health Organization (WHO) procedure using rTF 95 international reference preparation (IRP) of thromboplastin (human recombinant). These calibrants, along with five similarly characterized individual OAT patient plasmas, were distributed to 127 laboratories in a multi-center study. Calibrant plasmas were evaluated and INR’s subsequently determined on the 5 OAT test samples using: 1) the ISI and MNPT in place before the study (the local system), 2) the locally calibrated ISI value (local system with ISI calibration) and 3) a PT-INR calibration curve. Precision of INR results improved across the study group using the local system with ISI calibration and the PT-INR calibration curve methods, while accuracy of INR results improved using the PT-INR calibration curve approach only and not the local ISI calibration. The authors conclude that frozen plasma calibrants can be used locally to enhance precision and accuracy of PT results as reported in INR. These calibrants are effective over a range of reagents and instrument combinations. Furthermore, the PT-INR calibration curve appears to be the superior method for local calibration.
Synergistic Effect of Thrombomodulin Promoter -33G/A Polymorphism and Smoking on the Onset of Acute Myocardial Infarction
Authors: Li Yi-Heng , Tsai Wei-Chuan , Chao Ting-Hsing , Guo How-Ran , Tsai Liang-Miin , Wu Hua-Lin , Shi Guey-Yueh , Chen Jyh-Hong
Published: March 2018

Thrombomodulin is an endothelial cell surface receptor for thrombin. It plays an important role in the regulation of blood coagulation by decreasing thrombin activity and activating protein C. This study examined the possible association between the thrombomodulin -33G/A polymorphism and acute myocardial infarction. We recruited 278 patients (mean age 57.5 years, 241 men) with documented myocardial infarction and 450 age-and sex-matched control subjects. Polymerase chain reaction and single-strand conformation polymorphism was used to define the thrombomodulin -33G/A polymorphism. The frequency of the thrombomodulin GA+AA genotype among patients with myocardial infarction was higher than that in control subjects (22.7% vs. 16.2%, odds ratio [OR] 1.5, 95% confidence interval [CI] 1.0 to 2.2). The -33G/A polymorphism (GA+AA genotype) was significantly associated with myocardial infarction (OR 1.6, 95% CI 1.1 to 2.5) as was hypertension, diabetes mellitus and smoking. Among young myocardial infarction patients (age ≤45 years, n = 72), the frequency of -33G/A polymorphism was more significantly higher than that in control subjects (29.2% vs. 16.2%, OR 2.1, 95% CI 1.2 to 3.8). The -33G/A polymorphism (OR 2.3, 95% CI 1.3 to 4.1) and smoking (OR 4.5, 95% CI 2.5 to 7.9) were the only independent risk factors for young myocardial infarction. Furthermore, among patients who did not smoke, the polymorphism was associated with a nonsignificant increase in the risk of young myocardial infarction (OR 1.9, 95% CI 0.6 to 5.6); whereas, in the presence of smoking, the increase was statistically significant (OR 2.3, 95% CI 1.2 to 4.7). Smoking carriers of the thrombomodulin -33G/A polymorphism had a nearly 10-fold increased risk of young myocardial infarction (OR 9.8, 95% CI 4.3 to 22.4) when compared with nonsmoking non-carriers. We concluded that there was a significant association between the thrombomodulin -33G/A polymorphism and myocardial infarction in our population, especially in young patients. The clinical effect of this genetic factor was enhanced by smoking.
Short-Term Inhibition of ADP-Induced Platelet Aggregation by Clopidogrel Ameliorates Radiation-Induced Toxicity in Rat Small Intestine
Authors: Wang Junru , Albertson Christopher , Zheng Huaien , Fink Louis , Herbert Jean-Marc , Hauer-Jensen Martin
Published: March 2018

Endothelial dysfunction and increased platelet aggregation may be involved in the pathogenesis of normal tissue radiation toxicity. This study assessed clopidogrel, an inhibitor of ADP-induced platelet aggregation, as a modulator of intestinal radiation injury (radiation enteropathy).

Rat small intestine was exposed to 21 Gy X-radiation. Clopidogrel (20 mg/kg/day) or vehicle was administered from 2 days before to 10 days after irradiation. Structural radiation injury, neutrophil infiltration, smooth muscle cell proliferation, collagen content, and TGF-β1 expression were assessed 2 weeks (early phase) and 26 weeks (delayed phase) after irradiation, using quantitative histology and immunohistochemistry, morphometry, and real-time fluorogenic probe RT-PCR.

Irradiated intestine exhibited significant histopathologic injury, reduced mucosal surface area, vascular sclerosis, intestinal wall fibrosis, increased collagen content, and increased TGF-β1 expression. Clopidogrel reduced ADP-induced platelet aggregation by 93% and significantly attenuated the severity of post-radiation vascular sclerosis (p = 0.004 and p = 0.02) and the loss of mucosal surface area (p = 0.0008 and p = 0.003) at both 2 and 26 weeks. Clopidogrel also ameliorated overall histopathologic injury (p = 0.02), relative intestinal collagen content (p = 0.03), and collagen III immunoreactivity levels 2 weeks after irradiation, and caused a borderline reduction in the radiation-induced increase in extracellular matrix-associated TGF-β immunoreactivity at 26 weeks (p = 0.04). The effects of clopidogrel on steady-state TGF-β1 mRNA levels and neutrophil infiltration were not statistically significant.

Short-term clopidogrel administration affords protection against early and, to a lesser extent, delayed radiation enteropathy. Modulation of platelet aggregation should be subject to further studies as a potential method to increase safety and efficacy of radiation therapy.
Human Platelet Gαq Deficiency Is Associated with Decreased Gαq Gene Expression in Platelets but not Neutrophils
Authors: Gabbeta J. , Vaidyula V. R. , Dhanasekaran D. N. , Rao A. K.
Published: March 2018

G-proteins play an important role in platelet signal transduction and regulate responses upon activation of G-protein coupled receptors (GPCR). We have previously reported a patient with impaired platelet responses associated with deficiency in platelet Gαq. To understand the molecular basis for this defect, the cDNA sequence encoding Gαq (1080 bp) was obtained by reverse-transcription and polymerase chain reaction of platelet RNA; the cDNA sequence showed no mutations in the patient. Platelet Gαq mRNA levels were decreased by >50% compared to normal subjects; platelet Gαi2 mRNA levels were normal. Neutrophil calcium mobilization and elastase secretion, upon activation with several agonists, and neutrophil Gαq mRNA and protein levels were normal. These studies demonstrate that the patient has a defect in Gαq gene expression in platelets but not neutrophils, possibly due to defects in transcriptional regulation or mRNA stability, and suggest a hematopoietic-lineage specific defect.
Laboratory Diagnosis of Lupus Anticoagulants for Patients on Oral Anticoagulant Treatment
Authors: Chantarangkul Veena , Clerici Marigrazia , Mannucci Pier , Tripodi Armando
Published: March 2018

The detection of lupus anticoagulant (LA) in plasmas from patients on oral anticoagulants is problematic because of their prolonged clotting times. Mixing of patients and normal plasmas prior to testing for LA is employed to overcome this problem. We investigated the diagnostic efficacy of silica clotting time (SCT) and dilute Russell viper venom test (dRVVT) performed at low and high phospholipid concentrations, to diagnose LA in patients on oral anticoagulants, in comparison with Staclot® LA (Stago) performed with and without hexagonal phospholipids and normal plasma. Case materials were 114 filtered plasmas from patients on oral anticoagulants with (n = 62) and without (n = 52) the antiphospholipid syndrome. Plasmas were considered LA-positive when Staclot® LA (taken as the “gold standard”) was diagnostic for LA. Forty-four plasmas were positive with Staclot® LA. Forty and 39 of these were also positive with SCT and dRVVT (sensitivity relative to Staclot® LA was 91% and 89%, respectively). Seventy plasmas were negative with Staclot® LA. Three of these were positive with both SCT and dRVVT (specificity relative to Staclot® LA was 96%). Kappa values for measure of agreement were 0.87 and 0.85 (p <0.001), respectively. In conclusion, SCT and dRVVT performed at low and high phospholipid concentrations without normal plasma can be considered as reliable as Staclot® LA peformed with hexagonal phospholipids and normal plasma to diagnose LA in patients on oral anticoagulants. Advantages of SCT and dRVVT over Staclot® LA are easy automation, no need for normal plasma and relatively low cost.
Effects of Transdermal and Oral Oestrogen Replacement Therapy on C-Reactive Protein Levels in Postmenopausal Women: A Randomised, Placebo-Controlled Trial
Authors: Post M. S. , Stehouwer C. D. A. , van Baal W. M. , Mijatovic V. , Schalkwijk C. G. , Kenemans P. , van der Mooren M. J.
Published: March 2018

To investigate the effect of postmenopausal oral and transdermal hormone therapy on plasma levels of C-reactive protein (CRP), we performed a randomised, double-blind, double-dummy, placebo-controlled, 15-month study. One hundred and fifty-two healthy hysterectomised postmenopausal women received daily either placebo (n = 49), or transdermal 17 β-oestradiol (E2) 50 µg (tE2 group, n = 33), or oral E2 1 mg (oE2 group, n = 37), or oral E2 1 mg combined with gestodene 25 µg (oE2 + G group, n = 33) for thirteen 28-day treatment cycles, followed by four cycles placebo for each group. Data were collected at baseline and in cycles 4, 13 and 17. In cycle 13, CRP was significantly increased in the oE2 group compared to placebo (P = 0.004). The median percentage change from baseline versus placebo was +75% (P <0.001). In cycle 17, significantly lower values were observed in the oE2 group compared to cycle 13 and to the placebo group (-49%, P <0.001). There were no significant changes versus placebo in the other groups. In conclusion, oral E2 significantly increased CRP levels. This change was larger than the increase found during oral E2 + G. Transdermal E2 did not affect CRP levels.
Protein C Deficiency caused by Homozygosity for a Novel PROC D180G Mutation – in vitro Expression and Structural Analysis of the Mutation
Authors: Gedde-Dahl Tobias , Tjønnfjord Geir , Villoutreix Bruno , Brosstad Frank , Lind Bent
Published: March 2018

Summry

Homozygosity for a novel D180G mutation in the protease domain of protein C, associated with plasma protein C activity and antigen levels of 8% of normal was identified in a thrombosis prone family. Transient expression of protein C in HK-293 cells and analysis of protein C antigen in culture media and cell lysates showed that the secretion of mutant protein as compared with wild-type protein was reduced by 79% while the intracellular contents were similar. Computer analysis of the X-ray structure of activated protein C and of a theoretical model of the zymogen predicts that the mutation destabilises the molecule locally. Our results are compatible with a relatively unstable mutant molecule that could be trapped inside the cell and degraded. However, if secreted the mutant molecule could have a relatively normal catalytic activity and structure consistent with the plasma levels of protein C activity and the late onset of thrombosis.
Aurintricarboxylic Acid Attenuates Intimal Thickening after Balloon Injury of the Rabbit Aorta
Authors: Waissbluth Alvaro , Abendschein Dana , Eisenberg Paul , Ghigliotti Giorgio , Schwartz David
Published: March 2018

Injury to the arterial wall initiates a cascade of events including platelet deposition and an increase in procoagulant activity of the vessel wall that is associated with intimal thickening and vascular wall remodeling. This study was designed to characterize the effects of aurintricarboxylic acid (ATA), an inhibitor of von Willebrand factor function, on vascular procoagulant activity and the development of intimal thickening after balloon-induced injury to the rabbit aorta.

Treatment with ATA, aspirin, or the combination of agents at doses that attenuated platelet aggregation decreased platelet deposition and procoagulant activity bound to the vessel wall after injury. Treatment with ATA reduced the intimal thickening observed 2 weeks after injury. Surprisingly, aspirin treatment had no effect on intimal thickening. These data indicate that inhibition of platelet deposition, while it is able to attenuate local thrombin elaboration, is not alone sufficient to attenuate subsequent intimal thickening that occurs in response to arterial injury.