bluuebunny/crossref_metadata_2025 huggingface dataset:
Upregulated miR-486 Induces Therapeutic Angiogenesis and Improves Infarction Recovery in Rat Myocardial Ischemia Model
Authors: Qi Hong-Wei , Zhang Hai-Tao , Sun Hui-Yan , Zhang Lin , Sun Yang , Wang Li-Sheng , Yuan Biao
Published: February 2021

BackgroundBesides hematopoietic cells, miR-486 is also enriched in cardiac, skeletal, and smooth muscles. However, its roles in regulating the function of cardiomyocytes and tissue repair in myocardial infarction have not been explored yet.MethodsWe investigated the effects of miR-486 on the survival and hypoxic response of cardiomyocytes. Also, using adenovirus-mediated overexpression, we evaluated its therapeutic effects in myocardial repair in a rat acute myocardial infarct (AMI) model.ResultsHypoxia treatment upregulated miR-486 in cardiomyocytes. Moreover, adenovirus-mediated overexpression of miR-486 reduced cell injury, increased cell viability, and decreased apoptosis in hypoxic conditions. In a rat AMI model, administration of Ad-miR-486 reduced infarct size and collagen deposition, increased vessel density, and improved cardiac function. Furthermore, in vivo data suggest that the protective effects of miR-486 in cardiomyocytes were related to its anti-apoptotic function.Conclusion﻿miR-486 overexpression protects myocytes from hypoxia-induced apoptosis and has therapeutic potential in myocardial infarction.
Hydrochemical Characteristics and Water Quality of Groundwater in the Thick Loess Deposits
Authors: Li Shujian , Su He , Li Zhi
Published: February 2021

Water quality and quantity should be paid more attentions for regions with arid climate and thick vadose zones since the limited groundwater cannot be replenished rapidly once polluted. This study focused on the Loess Plateau of China to investigate the geochemical mechanism affecting groundwater chemistry and to calculate contribution rates of multiple sources to groundwater solutes. We employed multiple methods (diagrams, bivariate analyses, hierarchical cluster analysis (HCA), sodium adsorption ratio (SAR), water quality index (WQI), correlation analysis, forward simulation) for the above purposes. We collected 64 groundwater samples in the thick loess deposits in June 2018 (flood season) and April 2019 (dry season). The average concentrations of cation were in the order of Ca2+ > Na+ > Mg2+ > K+ in the flood season, and Na+ > Ca2+ > Mg2+ > K+ in the dry season. The order of anions contents in the flood season and the dry season was HCO3− > SO42− > Cl− > NO3−. The major hydrochemical facies were Ca-HCO3 and Ca·Mg-HCO3 in the flood season, and Na·Ca-HCO3·SO4 and Na-HCO3 in the dry season, respectively. Most of the groundwater (95% in the flood season and 96% in the dry season) was suitable for drinking, and overall water quality (except samples F28 and D13) was acceptable for irrigation. Mineral dissolution and cation exchange were important natural processes affecting groundwater chemistry. A forward model showed that the contribution of atmospheric input, anthropogenic input, evaporite dissolution, silicate weathering and carbonate weathering to solutes in groundwater was 2.3 ± 1.5%, 5.0 ± 7.1%, 19.3 ± 21.4%, 42.8 ± 27.3% and 30.6 ± 27.1% in the flood season, and 9.1 ± 6.4%, 3.4 ± 5.2%, 20.3 ± 15.9, 56.6 ± 23.2%, and 10.7 ± 15.4% in the dry season, respectively. Although the overall contribution of anthropogenic inputs was minor, it was the dominant source of solutes for some groundwater samples. This study provides fundamental information for water management in arid areas.
Isolated Synchronous Multiple Splenic Metastases From Rectal Cancer: a Case Report and Review of the Literature
Authors: Zhao Linxian , Cao Lanqing , Cui Fengwen , Li Wei , Liu Tongjun , Zhang Kai , Li Jiannan
Published: February 2021

Background: Isolated splenic metastasis emanating from colorectal cancer is an extremely rare finding, which usually indicates widely disseminated and multiple metastatic cancer. There have only been 39 cases of isolated splenic metastasis reported in the English literature to date. Case presentation: We report a case of synchronous and isolated multiple splenic metastases derived from rectal cancer. An 84-year-old woman, who presented with and an increased serum carcinoembryonic antigen (CEA) level, was diagnosed with rectal cancer with splenic metastases by abdomen computed tomography (CT). The patient underwent a radical resection of rectal cancer and splenectomy, and the postoperative histopathology conﬁrmed that the splenic lesions were derived from the adenocarcinoma of the rectum. After surgery, the patient recovered well and was recommended for further chemotherapy. Conclusion: Our findings enrich the database of this rare clinical entity and provide experience in the management of splenic metastasis. In addition to revealing a rare case, we also performed a literature review, including a brief discussion about the atypical isolated splenic metastasis from colorectal cancer (CRC).
The Eruption Patterns of The Teeth of Nigerian Local Pigs. Part 1: Profile of Deciduous Teeth
Authors: Okandeji Michael Efeturi , Lijoka Ayodeji David , Atiba Folusho Ayobami , Olopade James Olukayode
Published: February 2021

Background: The pigs, domesticated about 6000 years ago, are highly prolific omnivores belonging to the Family Suidae and Order artiodactyla along with their other hooved counterparts. They qualify as models for various translational research studies (including dental studies) because of their anatomical and physiological similarities to humans. There is however a dearth of information as regards the deciduous dental eruption profile (sequence and timing of eruption) of the Nigerian local pigs (NLP). This study was designed to determine the deciduous eruption profile in the NLP to assist in the management of the breed and in a bid to making the NLP more obvious as suitable animal models in dental research. A total of 51 healthy piglets (from postnatal day 1) were used for this. Their oral cavities were examined every other day for 29 weeks for signs of dental eruption. Looking at Mandibular (Md) and Maxillar (Mx) eruptions for Incisors (I), Canines(C), Premolars (P) and Molars (M), the modular sequence in the NIP was Md/ Mx I3(at birth), C (at birth) →Md I1→Md P3→MxP3 →MxI1 → Md I2 →MdP4 →MxP4 →MxP2→ Md I2 →MxI2 . Result: It was observed that variations in eruption timing exist amongst individuals and sexes while variation in eruption sequence exists between NLP and various breeds of pigs based on the literature.Conclusion: The results of this study will be particularly important to farmers, and researchers into NLP especially those using pigs in Nigeria as a model for translation research.
Surgical Management of Bacille Calmette-Guérin Vaccine-related Regional Lymphadenitis in Infants
Authors: Liu Chen , Huang Minxiang , Geng Lei , Ding Guojian , Liu Xijie , Zheng Bufeng , Feng Wenyu , Fu Tingliang , Xu Xiaoliang
Published: February 2021

BackgroundThe management of Bacille Calmette-Guérin (BCG) vaccine-related regional lymphadenitis in infants is still controversial. We present the results of surgical treatment for this condition.AimTo report our experience in the surgical management in infants with BCG vaccine-related regional lymphadenitis.ResultsFrom January 2013 to June 2020, 65 patients with BCG vaccine-related regional lymphadenitis were retrospectively reviewed. The patients included 55 boys and ten girls. Median age was 3.35 months (5.83±8.17, IQR 3.35-5.1). The infants were all full-term with normal birth weight and received vaccination in the first 24 h of life. All patients underwent surgical excision of the abscess and involved regional lymph nodes, and tolerated anesthesia and the surgical procedure well. Postoperative seroma occurred in 20 patients (20/65). The effusion was aspirated with a fine needle. Sixty-four patients recovered uneventfully. No anti-tuberculosis drugs were given postoperatively. Postoperative abscess recurred in one case and re-operation was required one year later. Postoperative follow-up of three to 12 months showed that all patients had a good outcome.ConclusionSurgical management of infantile BCG vaccine-related lymphadenitis is safe and effective with a low recurrence rate and few complications. Surgical intervention shortened the treatment period and avoided the use of anti-tuberculosis drugs. Surgeons should follow the natural course of this disease and be cautious in choosing surgical treatment.
Building a Weighted Performance Indicator Concept Utilized The Respondent’s Opinion Approach
Authors: Terttiaavini  , Hartono Yusuf , Ermatita Ermatita , Rini Dian Palupi
Published: February 2021

This study discusses building the concept of weighting performance indicators based on respondents' opinions. The opinion of respondents has the power to provide an assessment. So far, the performance appraisal is determined based on the Balanced Scorecard method, AHP, Topics, and others where the dimensions of this method are limited. In companies, performance appraisals are carried out by the HR Department. The specified indicator is sometimes too high, therefore it is considered achieved. The most flexible approach in which the determination of indicators is determined by the respondent who will implement the rule. Weighted performance indicators are constructed by developing an association rule method and ranking method. Performance appraisal structures in the form of multi values ​​and multidimensional can be built using this concept. Items that meet the support value and minimum weight are determined based on the higher frequency. This concept is a new proposal from a mining method developed to produce a performance appraisal model that can be applied to various needs.
Electrical Stimulation of the Common Peroneal Nerve and Its Effects on the Relationship Between Corticomuscular Coherence and Motor Control in Healthy Adults
Authors: Koseki Tadaki , Kudo Daisuke , Katagiri Natsuki , Nanba Shigehiro , Nito Mitsuhiro , Tanabe Shigeo , Yamaguchi Tomofumi
Published: February 2021

Background: Sensory input via neuromuscular electrical stimulation (NMES) may contribute to synchronization between motor cortex and spinal motor neurons and motor performance improvement in healthy adults and stroke patients. However, the optimal NMES parameters used to enhance physiological activity and motor performance remain unclear. In this study, we focused on sensory feedback induced by a beta-band frequency NMES (β-NMES) based on corticomuscular coherence (CMC) and investigated the effects of β-NMES on CMC and steady-state of isometric ankle dorsiflexion in healthy volunteers. Twenty-four participants received β-NMES at the peak beta-band CMC or fixed NMES (f-NMES) at 100 Hz on different days. NMES was applied to the right part of the common peroneal nerve for 20 min. The stimulation intensity was 95% of the motor threshold with a pulse width of 1 ms. The beta-band CMC and the coefficient of variation of force (Force CV) were assessed during isometric ankle dorsiflexion for 2 min. In the complementary experiment, we applied β-NMES to 14 participants and assessed beta-band CMC and motor evoked potentials (MEPs) with transcranial magnetic stimulation.Results: No significant changes in the means of beta-band CMC, Force CV, and MEPs were observed before and after NMES conditions. Changes in beta-band CMC were correlated to a) changes in Force CV immediately, at 10 min, and at 20 min after β-NMES (all cases, p < 0.05) and b) changes in MEPs immediately after β-NMES (p = 0.01). No correlations were found after f-NMES.Conclusions: Our results suggest that the sensory input via NMES was inadequate to change the beta-band CMC, corticospinal excitability, and voluntary motor output. Whereas, the β-NMES affects the relationship between changes in beta-band CMC, Force CV, and MEPs. These findings may provide the information to develop NMES parameters for neurorehabilitation in patients with motor dysfunction.
Description of a Zooxanthellate Scleractinian Coral (Blastomussa Angulares sp. nov.) from Lakshadweep, India
Authors: Mondal Tamal , Raghunathan C.
Published: February 2021

One species zooxanthellate scleractinian coral i.e. Blastomussa angulares sp. nov. is described from Lakshadweep atoll for the first time based on the morphometric characteristics. The significant characters which differentiate this presently described species from previously known species are shape of angular corallites, length of the corallite diameter, number of septa and their cycles, highly exsert septa, structure of columella and septa like extra projection from the basal plate. Blastomussa angulares sp. nov. represents close structural affinities with B. loyae Head, 1978 which is briefly narrated here to establish the presently designated species.
Video-Delivered Emotion-Focused Mindfulness Therapy for late- life anxiety: Study Protocol for a Feasibility Randomized Controlled Trial During COVID-19
Authors: Hatch Stacey Elinor , Kessler Dorothy , Finlayson Marcia , Rej Soham
Published: February 2021

Background: The worldwide prevalence of anxiety in older adults is estimated at between 6% and 10%. In Canada, adults 65 and older experience anxiety at a rate of 6.4%, affecting more than 300,000 people. Anxiety in older adults has been linked to difficulties retaining new information and engaging in instrumental daily activities of living. Due to COVID-19 restrictions, novel methods of delivering therapy programs remotely are needed, however data is limited. There is some evidence that older adults prefer non-pharmacological approaches for anxiety that can be delivered in the community. Emotion-Focused Mindfulness Therapy (EFMT) is a mindfulness-based intervention that emphasizes meditation and observing thoughts and emotions as they arise. This emphasis has been demonstrated to reduce symptoms of anxiety in general populations. This study aims to evaluate the feasibility of EFMT with older adults.Methods: This pilot feasibility randomized controlled trial will use a wait list control trial design. Due to COVID-19 restrictions, we will use telehealth delivery via Zoom rather than in-person delivery. The first 48 people to meet the eligibility criteria will be randomly allocated to either receive EFMT immediately, or in approximately eight weeks time from enrollment (1:1 allocation ratio). Data will be collected at baseline, eight weeks following baseline, and sixteen weeks following baseline. The primary outcomes will determine the feasibility of the intervention based on recruitment, enrolment, retention and adherence to all components of the intervention. The secondary outcome will be changes to anxiety over time.Discussion: The results of this trial will determine the feasibility and potential effectiveness of video-delivered EFMT for late-life anxiety compared to no treatment. If the results are promising, a larger randomized controlled trial may be conducted.Trial registration: ClinicalTrials.gov: NCT04415528. Registered on June 4, 2020Protocol version: Protocol version 2, January 2, 2021
Optimization of Tandem Affinity Chromatography (TAP) for Effective Isolation and Identification of Protein Complexes Involved in Molecular Mechanism of Depression.
Authors: Fic Ewelina , Cieslik Agata , Dziedzicka-Wasylewska Marta
Published: February 2021

According to the World Health Organization Report, depressive disorders affect about 10% of the population. The molecular mechanism of the pathogenesis of depression is still not well understood. The new findings point to phosphatases as potential targets for effective depression therapy. The aim of the project is the development of method that would enable the identification of Mitogen-Activated Protein Kinase Phosphatase-1 (MKP-1) protein partners using proteomic techniques. The research was carried out using the PC12 cell line, often used as a model for neurobiological research. The use of the procedure for efficient purification of protein complexes – Tandem Affinity Purification (TAP) will facilitate the identification of proteins interacting with MKP-1, a potential goal of effective antidepressant therapy. The presented protocol for purification of protein complexes is universal and can be successfully used in different mammalian cell lines. Identified proteins belong to various groups: cytoskeletal, ribosomal, nucleic acid binding, chaperones, enzymes and may potentially be involved in the molecular mechanism of depression.
Assessment of Clinical, Socio-demographic Profile and Stressors in patients with Conversion/Dissociative Disorders: An Exploratory study from Southern India
Authors: Bammidi Ravi , Kumar K. Suresh Abu , Bashar MD Abu
Published: February 2021

Background

Patients present with ‘conversion disorder’ as a response to the underlying stressful situation. It is clinically important to evaluate the presence, type, and temporal relation of the stressors resulting in conversion. Further knowing the Socio-demographic and psychological profile of the conversion patient helps in better management.
Aim

To study the clinical presentations, Socio-demographic characteristics and underlying stressors associated with conversion disorder.
Methods

Fifty patients admitted to the department of psychiatry, NRI Medical College and Hospital, Vishakhapatnam, during January 2013 to December, 2014 who fulfilled the inclusion criteria of the study were evaluated for Socio-demographic characteristics, clinical presentations and stressor on a semi-structured proforma.
Results

Majority of the patients with conversion symptoms were children and young adults (74.0%), females (62.0%), students (46.0%), married (54.0%) and those from nuclear families (78.0%) and rural background (62.0%). Socioeconomic status wise, majority (66.0%) of the patients belonged to middle class. Majority of the patients (92.0%) had a recognizable precipitating factor, of which family-related/marital (36.0%) and education/school-related (18.0%) problems accounted for the major types. Purely motor symptoms were the predominant presentation (84.0%) with unresponsiveness /syncopal attack and pseudo seizure being the commonest.
Conclusion

Conversion disorders are commonly seen in females, children and young adults, students and in those belonged to middle class in socioeconomic status and rural areas. Underlying psycho-social stressors could be identified in majority of the cases of conversion disorder.
Metabolic Syndrome, Its Components and Risk of Cardiometabolic Multimorbidity: Findings From the UK Biobank Cohort
Authors: Qiao Yanan , Liu Siyuan , Li Guochen , Lu Yanqiang , Wu Ying , Ding Yi , Ke Chaofu
Published: February 2021

Background: Metabolic syndrome (MetS) and its components have been acknowledged as risk factors for a single cardiometabolic disease, but their relationship with the risk of cardiometabolic multimorbidity is unclear. The present study aimed to prospectively investigate the association of MetS and its components with the risk of cardiometabolic multimorbidity.Methods: In this prospective cohort study, we analyzed data of 353,427 participants from the UK Biobank. Participants with a previous diagnosis of cardiometabolic disease or those with missing data on the items of MetS were not eligible. Cardiometabolic multimorbidity was defined as the co-existence of two and more conditions of type 2 diabetes, coronary heart disease (CHD), and stroke. Cox proportional hazards models were used to estimate the hazard ratios (HRs) and 95% confidence intervals (95% CIs) for the relationship between MetS, components of MetS and cardiometabolic multimorbidity. Results: During a median of 8.9 years of follow-up, 3389 participants developed the cardiometabolic multimorbidity. Compared with individuals without MetS, individuals with MetS had a three times higher risk of developing cardiometabolic multimorbidity (adjusted HR: 3.02, 95% CI: 2.82-3.24). The accumulation of MetS components was associated, in a dose-response manner, with the risk of cardiometabolic multimorbidity (P for trend <0.0001). For the temporal sequences in the development of cardiometabolic diseases, the corresponding HRs (95% CIs) for individuals with ≥4 metabolic abnormalities were 1.57 (1.47-1.68) for cardiovascular disease only, 10.27 (7.62-13.84) for cardiovascular disease with subsequent diabetes, 25.34 (21.95-29.24) for diabetes only, and 42.97 (21.19-87.13) for diabetes with subsequent cardiovascular disease.Conclusions: MetS was independently associated with the risk of cardiometabolic multimorbidity, and the risk substantially increased with a greater number of MetS components. Our findings highlight the importance of screening and treatment of MetS in the prevention of cardiometabolic multimorbidity.
Environmentally-friendly Inhibitor From Waste for Aluminium Corrosion in 0.5M Sulphuric Acid Environment
Authors: Sanni Omotayo , Fayomi OSI , Popoola API
Published: February 2021

This research aims to identify cheap, effective, and green inhibitors from agricultural waste (coconut shell) as sustainable inhibitors for pure cast aluminium corrosion in 0.5 molar sulphuric acid medium at different concentrations. The inhibitive effect of coconut shell (CS) in 0.5 molar sulphuric acid solutions on aluminium was studied using series of standard corrosion monitoring methods: gravimetric and electrochemical techniques. The nature of adsorption and aluminium surface morphology was conducted with scanning electron microscopy and energy-dispersive X-ray spectroscopy (SEM/EDX) method. The obtained result implies that the CS can serve as an environmentally friendly inhibitor for aluminium corrosion in 0.5 molar H2SO4 environments with the highest corrosion inhibition efficiency of 99% at 10 g. The inhibition mechanism was proposed to be physical adsorption and fits the Langmuir adsorption isotherms. The inhibitive effect of CS was proposed to be a mixed inhibition mechanism as shown by the potentiodynamic polarization method. The SEM and EDX observation show that the CS species formed a protective layer on the aluminium surface. The results obtained confirmed that CS is a sustainable inhibitor, which could be used in the industry as an environmentally friendly corrosion inhibitor.
Tumor Type, Epilepsy Burden, and Seizure Documentation: Experiences at a Single Center Neuro-Oncology Clinic
Authors: Bushara Omar , Guzner Alex , Bachman Elizabeth , Stupp Roger , Lukas Rimas V , Templer Jessica W.
Published: February 2021

Purpose: Patients with both primary and metastatic brain tumors have significant seizure burden due to their tumor. We aim to describe seizure incidence in patients seen in neuro-oncology clinical practice. In addition, as the management of tumor related epilepsy (TRE) may require collaboration between subspecialists, documentation regarding seizures and AEDs is evaluated.Methods: This is a retrospective review of patients with a primary brain tumor or brain metastases seen in a neuro-oncology clinic in a 30 day period. A total of 356 unique patients were used in the descriptive analysis of seizure burden. 199 of these patients had TRE and were included in the analysis of seizure documentation. Results: Of the full cohort of patients, 55.3% (197/356) had TRE. The most common primary tumor was glioblastoma (GBM) (35.7%) and the most common metastatic tumor was breast cancer (51.2% of metastatic tumors). Of all tumor types, anaplastic astrocytomas had the highest percentage of patients with TRE (42.9%).The analysis of seizure documentation in patients with TRE revealed that the majority of notes (90.9%) mentioned seizures; however, fewer notes provided seizure frequency (51.3%), seizure descriptions (39.7%) or commented on AED regimens (58.3%).Conclusion: This study defines a representative cohort of patients seen in neuro-oncology clinic. Among patients with TRE, details regarding seizures and antiepileptic regimens are often not documented in clinic notes. Improved documentation could facilitate further research in this population and impact patient care.
A new result under weak and non-relativistic approximation from general theory of relativity
Authors: Samanta Abhijit
Published: February 2021

We have derived a metric field equation in the locally inertial coordinate system from Einstein's field equation considering the energy density of the moving particle with the approximations that the force field under which the particle is moving is weak and the velocity of the particle is non-relativistic.
We study the motion of different microscopic systems using this metric equation and compared the results with the experimentally measured values and we find that the results are identical.
Entomological Survey for Identification of Aedes Larval Breeding Sites and Their Distribution in Chattogram, Bangladesh
Authors: Rahman Md. Sahidur , Faruk Md. Omar , Tanjila Sumiya , Sabbir Nur Mohammad , Haider Najmul , Chowdhury Sharmin
Published: February 2021

Background: Studying the characteristics of Aedes mosquito habitats is essential to control the mosquito population. The objective of this study was to identify the breeding sites of Aedes larvae and their distribution in the Chattogram. We conducted an entomological survey in 12 different sub-district (Thana) under Chattogram city, Bangladesh, during the late monsoon (August to November) 2019. The presence of different wet containers along with their characteristics and the existence of immature mosquitoes were recorded in field survey data-form. Larvae and/or pupae were collected and brought to the laboratory for identification. Results: We estimated the overall house index, container index, and the Breteau index and performed multiple logistic regression analyses to identify habitats more likely to be positive for Aedes larvae/pupae. Out of a total of 704 wet containers of 37 different types from 216 properties where 52 (7.39%) containers were positive for Aedes larvae or pupae. Tire, plastic buckets, plastic drums, and coconut shells were the most prevalent container types. The plastic group possessed highest container productivity (n=50) whereas vehicle and machinery group was the highest efficient (1.83). Among the total positive properties, 8% were infested with Aedes aegypti, 2% were Aedes albopictus and 1% contains both species Ae. aegypti and A. albopictus. The overall house index was 17.35%, container index was 7% and the Breteau index was 24.49. Containers in multistoried House had significantly lower positivity in compare to independent house. Binary logistic regression represented that containers having shade were 6.7 times more likely to be positive than the containers without shade (p< 0.01). Conclusions: These findings might assist the authorities to identify the properties, containers, and geographical areas with different degrees of risk for mosquito control interventions to prevent dengue and other Aedes-borne diseases transmissions.
Low-dose IL-34 has no effect on osteoclastogenesis but promotes osteogenesis of hBMSCs partly via activation of the PI3K/AKT and ERK signaling pathways
Authors: Xu Jianxiang , Fu Lifeng , Bai Jinwu , Zhong Huiming , Kuang Zhihui , Zhou Chengwei , Hu Bin , Ni Licheng , Ying Li , Chen Erman , Zhang Wei , Wu Jiaqi , Xue Deting , Li Weixu , pan zhijun
Published: February 2021

Background: Inflammatory microenvironment is significant to the differentiation and function of mesenchymal stem cells(MSCs). It evidentially influences the osteoblastogenesis of MSCs. IL-34, a newly discovered cytokine, playing a key role in metabolism. However, the research on its functional role in the osteogenesis of MSCs was rarely reported. Here, we described the regulatory effects of low-dose IL-34 on both osteoblastogenesis and osteoclastogenesis.Methods: We performed the osteogenic effects of hBMSCs by exogenous and overexpressed IL-34 in vitro, so was the osteoclastogenesis effects of mBMMs by extracellular IL-34. CCK-8 was used to assess the effect of IL-34 on the viability of hBMSCs and mBMMs. ALP staining, ARS and TRAP staining were used to evaluate ALP activity, mineral deposition and osteoclastogenesis, respectively. qRT-PCR and Western blotting analysis were performed to detect the expression of target genes and proteins. ELISA was used to evaluate the concentrations of IL-34. In vivo, a rat tibial osteotomy model and an OVX model were established. Radiographic analysis and histological evaluation were performed to confirm the therapeutic effects of IL-34 in fracture healing and osteoporosis. Statistical differences were evaluated by two-tailed Student’s t-test, one-way ANOVA with Bonferroni’s post hoc test and two-way ANOVA with Bonferroni multiple comparisons post hoc test in the comparison of 2 groups, more than 2 groups and different time points of treated groups, respectively. Results: Promoted osteoblastogenesis of hBMSCs was observed after treated by exogenous or overexpressed IL-34 in vitro, confirmed by increased mineral deposits and ALP activity. Furthermore, exogenous or overexpressed IL-34 enhanced the expression of p-AKT and p-ERK. The specific AKT and ERK signaling pathway inhibitors suppressed the enhancement of osteoblastogenesis induced by IL-34. In a rat tibial osteotomy model, imaging and histological analyses testified the local injection of exogenous IL-34 improved bone healing. However, the additional IL-34 has no influence on both osteoclastogenesis of mBMMs in vitro and osteoporosis of OVX model of rat in vivo. Conclusions: Collectively, our study demonstrate that low-dose IL-34 regulates osteogenesis of hBMSCs partly via the PIK/AKT and ERK signaling pathway and enhances fracture healing, with neither promoting nor preventing osteoclastogenesis in vitro and osteoporosis in vivo.
Tumors and Tumor like Conditions of Eye and Ocular Adnexae: A Comprehensive Study of 359 Cases
Authors: Choukimath Sharanabasav M , . Krishnaprasad , Choukimath Vaishali , Krishnaprasad Samhita
Published: February 2021

Background: The eye is one of the major sensory organs. The present study aims at a comprehensive study of all the tumours and tumour like conditions of eye and ocular adnexae with their relative incidence in Indian population.

Methods: All incisional and excisional biopsies of eye and its adnexal organs received in our laboratory between April - 2010 to December - 2018 were included in this study.

Result: A total of 350 cases were studied. Among these, lesions constituted are orbital: 37.4%, Conjunctival: 32%, Eyelid: 18.2%, Intraocular: 9.4% and Lacrimal gland: 2.85% of the total cases.  Among the orbital lesions, the most common benign tumor was hemangiomas [15.26 %] and malignant tumour was basal cell carcinomas [10%].

In conjunctiva, carcinoma in situ was the most common lesion [51.4%]. Retinoblastoma [66.66%] was the most common in the ocular lesions. Other tumours and tumour like conditions are discussed in the present study.

Conclusion: Early histopathological diagnosis and ancillary diagnostic tests like immunohistochemistry will help to reduce destructive surgeries and the morbidity in terms of vision loss, loss of eyeball and cosmetic factors. Present study aids in knowing the incidence and prevalence of tumor and other lesions seen with orbit, and its adnexa and eyeball.
Mapping current and activity fluctuations in exclusion processes: consequences and open questions
Authors: Vanicat Matthieu , Bertin Eric , Lecomte Vivien , Ragoucy Eric
Published: February 2021

Considering the large deviations of activity and current in the Asymmetric Simple Exclusion Process (ASEP), we show that there exists a non-trivial correspondence between the joint scaled cumulant generating functions of activity and current of two ASEPs with different parameters.
This mapping is obtained by applying a similarity transform on the deformed Markov matrix of the source model in order to obtain the deformed Markov matrix of the target model.
We first derive this correspondence for periodic boundary conditions, and show in the diffusive scaling limit (corresponding to the Weakly Asymmetric Simple Exclusion Processes, or WASEP)
how the mapping is expressed in the language of Macroscopic Fluctuation Theory (MFT).
As an interesting specific case, we map the large deviations of current in the ASEP to the large deviations of activity in the SSEP, thereby uncovering a regime of Kardar--Parisi--Zhang in the distribution of activity in the SSEP.
At large activity, particle configurations exhibit hyperuniformity [Jack et al., PRL 114, 060601 (2015)].
Using results from quantum spin chain theory, we characterize the hyperuniform regime by evaluating the small wavenumber asymptotic behavior of the structure factor at half-filling.
Conversely, we formulate from the MFT results a conjecture for a correlation function in spin chains at any fixed total magnetization (in the thermodynamic limit).
In addition, we generalize the mapping to the case of two open ASEPs with boundary reservoirs, and we apply it in the WASEP limit in the MFT formalism.
This mapping also allows us to find a symmetry-breaking dynamical phase transition (DPT) in the WASEP conditioned by activity, from the prior knowledge of a DPT in the WASEP conditioned by the current.
Light dark matter annihilation and scattering in LHC detectors
Authors: Bauer Martin , Foldenauer Patrick , Reimitz Peter , Plehn Tilman
Published: February 2021

We systematically study models with light scalar and pseudoscalar
dark matter candidates and their potential signals at the
LHC. First, we derive cosmological bounds on models with the
Standard Model Higgs mediator and with a new weak-scale
mediator. Next, we study two processes inspired by the indirect and
direct detection process topologies, now happening inside the LHC
detectors. We find that LHC can observe very light dark matter over
a huge mass range if it is produced in mediator decays and
then scatters with the detector material to generate jets in the
nuclear recoil.
Reward Manajemen untuk Membentuk Psychology Well-being dalam Mengurangi Terjadinya Demo
Authors: Mafuz Yunia Lailatul
Published: February 2021

The purpose of this journal research is to find how to provide salary system and THR to employees at PT Crevis Tex Jaya Subang West Java and analyze the impact and solution. With the method of reviewing case studies at PT Crevis Tex Jaya Subang West Java caused by the late payment of salaries to employees of PT Crevis Tex Jaya even THR still delinquent and make the employees down action or demo to demand their rights. Salary giving and THR have applicable invitations.
Tableau Business Intelligence Using the 9 Steps of Kimball’s Data Warehouse & Extract Transform Loading of the Pentaho Data Integration Process Approach in Higher Education
Authors: Lokaadinugroho Indrabudhi , Girsang Abba Suganda , Burhanudin Burhanudin
Published: February 2021

This paper discusses about how to build a data warehouse (DW) in business intelligence (BI) for a typical marketing division in a university. This study uses a descriptive method that attempts to describe the object or subject under study as it is, with the aim of systematically describing the facts and characteristics of the object under study precisely. In the elaboration of the methodology, there are four phases that include the identification and source data collection phase, the analysis phase, the design phase, and then the results phase of each detail in accordance with the nine steps of Kimball’s data warehouse and the Pentaho Data Integration (PDI). The result is a tableau as a tool of BI that does not have complete ETL tools. So, the process approach in combining PDI and DW as a data source certainly makes a tableau as a BI tool more useful in presenting data thus minimizing the time needed to obtain strategic data from 2-3 weeks to 77 minutes.
Analysis Inventory Cost Jona Shop with EOQ Model
Authors: Vania Abigail , Yolina Hanni
Published: February 2021

Jona Shop is located in Indonesia, Jakarta is currently having a problem. The problem is the shop’s owner thinks that the inventory costs are too big especially for a powdered drink which brand is “Nutrisari”. The author finishes an EOQ (Economic Order Quantity) model for minimize the inventory cost. EOQ model is an old model but a valid model which still used now. Even EOQ model is an old model, many researchers used EOQ model to minimize inventory cost until 50% or more than 50%. But the EOQ model has some assumptions and Jona Shop fulfilled all the assumptions in the EOQ model. The assumptions of EOQ model are demand is known and constant, the lead time is constant and known, only one product can be estimated, every order is accepted in one-time delivery and can be used right away, there is no backorder because run out stock, no discount, and the holding cost per year and the ordering cost per year are constant. The result of the EOQ model can save up to almost 90%.
AVALIAÇÃO DA CONCENTRAÇÃO TOTAL E DA FRAÇÃO BIOACESSÍVEL DE METAIS EM AMOSTRAS DE CASCA DE UVA DE CULTIVARES TANNAT E CABERNET SAUVIGNON POR MIP OES
Authors: Jacobs Bruno , Bonemann Daisa , Pereira Camila , Souza Alexander , Luckow Ana , Lisboa Meibel , Ribeiro Anderson , Cadore Solange , Nunes Adriane
Published: February 2021

EVALUATION OF THE TOTAL CONCENTRATION AND THE BIOACCESSIBLE FRACTION OF METALS IN SAMPLES OF GRAPE SKINS OF CULTIVARS TANNAT AND CABERNET SAUVIGNON BY MIP OES. This paper describes the evaluation of the total concentration of Ba, Bi, Ca, Cd, Co, Cr, Cu, Fe, K, Mn, Pb e Zn and the bioaccessible fraction of Ba, Cu, Fe, Mn, Pb and Zn in samples of grape skins from different cultivars (Vitis Viníferas Tannat and Cabernet Sauvignon) by MIP OES. For the determination of total concentration, acid decomposition with a reflux system adapted to the digestion tubes in the oxidizing medium of HNO3 and H2O2 were used. The accuracy of the method was verified by recovery tests, whose values ranged from 80 to 120%, as well as through a comparative method in closed system. Bi, Cd and Cr showed values for total content below the LOD or below the values acceptable for health while Pb is higher than 0.2 mg kg-1, for both cultivars. To evaluate the bioacessible fraction, the gastrointestinal system was simulated using an in vitro procedure, and its performance was assessed considering the bioaccessible fraction (supernatant) and the non-bioaccessible fraction, whose sum should be closed to the total concentration, and the results obtained were between 81 and 120%. Both cultivars showed similar values for the bioaccessible fractions (~13.5 – 53% of the total content).
Fault diagnosis of rolling bearings based on improved enhanced envelope spectrum
Authors: Huang Baoyu , Zhang Yongxiang , Zhu Danchen
Published: February 2021

Aiming at the problem that traditional fast spectral correlation (Fast-SC) cannot effectively extract the fault feature of rolling bearings under strong background noise, we propose to select a band with abundant fault information on the spectral frequency axis by Spectral Gini Index (SGI) and integrate over them to obtain the Improved Enhanced Envelope Spectrum (IEES). The proposed method doesn’t rely on the selection of precise fault characteristic frequency, and has a good industrial application prospect. The simulated and experimental results of rolling bearings prove the effectiveness of the algorithm.
Man as Image of God and Theological Implications of that Expression
Authors: Chriisten Eduard
Published: February 2021

Man as Image of God and Theological Implications of that Expression
Anthropological Bases On The Path To the Sanctification Of Man
Authors: Tatar Marek
Published: February 2021

Anthropological Bases On The Path To the Sanctification Of Man
The Theological Importance Of Creation In The Old Testament
Authors: Gołębiewski Marian
Published: February 2021

+. It is true that the concept of creation takes on theological focus in Israel quitelate. e chosen nation was primarily interested in history and its relationto God, and then asked a question about the beginning of the world. Over time,as a result of historical events, it gradually developed a lesson on creation. Babylonianslavery played a decisive role in the theological reflection on creation.&. e Old Testament texts testify that the statement “Yahweh has made heavenand earth” corresponds to a threefold theological intention. It has at the sametime a doxological, soteriological and polemic character. e Old Testamenttaken as a whole evokes a cosmogonic fact to praise the glory of the God of Israeland emphasise His transcendence, to question the worship of nature, freeingman from the caring cosmic and agrarian forces, and to guarantee salvationfor Israel and the world, relying on the power of God, able to make all thingsnew out of love for his chosen.3. e Old Testament shows us that the theological reflection on the creationof the world and mankind has been expressed in various forms in the historyof Israel, there is no single formula of Israel’s faith in creation, but it is alwaysabout the same faith expressed in a formulation conditioned by the currentcultural context, always with the triple theological intentions mentioned above.is can be seen in the Old Testament writings, starting with the Jehovah andthe priestly writer, through Deutero-Isaiah and the author of the Book of Job,whose faith was later expressed in the first article of the creed: “I believe in Godthe Almighty Father, the Creator of heaven and earth.”
The Dogma of Salvation in Jesus Christ, Presented in Various Ways in Prophesying and Explained in Theology
Authors: Łukaszuk Tadeusz
Published: February 2021

The Dogma of Salvation in Jesus Christ, Presented in Various Ways in Prophesying and Explained in Theology
The Concept of the Person as “Subject” and “Place” of Morality According to Paul Ricoeur
Authors: Sobkowiak Jarosław
Published: February 2021

e concept of the subjectivity of a person presented in this article has shownthat man as a subject appears in constant references and relations in which hisexistence is embedded. On the one hand, it escapes the determinism of nature,on the other hand, it reveals a certain crack between its nature and action. isleads to the conclusion that even if a person is characterised by individuality, itis not a separate existence. It seems justified to return to the question of whatmakes a person, in spite of both external and internal variability; they remain thesame or otherwise what builds and what destroys the subjectivity of the person?e question thus posed reveals the first threat to human subjectivity whichis the fact of the existence of evil. For it is not only something external to manbut also something that makes man both the “place” of the appearance of evil and responsible for evilB8. While staying in Ricoeur’s philosophy characterisedby a dialectical movement one can already see in the language discussing evila threat to certain “deposits of hope” present in his thoughtB<. For the religiouslanguage to which Ricoeur ultimately reduces the problem of evil is the languageof hope and eschatology. Freedom also takes on a new meaning in this context.It is no longer just something that has been enslaved but above all somethingthat is a “desire for the possible.” A possible freedom is the Resurrection. In thisperspective, even evil and suffering can find their ultimate meaning, and thesubjective character of morality does not threaten to fall into subjectivism.Moreover, it is in the name of such subjectivism that morality demands for thesubject this “otherness,” the hope that comes from the Resurrection.
Passover of Border Situations. Experience of Liturgy in Labor Camp Literature
Authors: Bortkiewicz Paweł
Published: February 2021

Passover of Border Situations.

Experience of Liturgy in Labor Camp Literature
Glycogen Synthase Kinase-3 (GSK-3) Inhibitors as a New Lead for Treating Breast and Ovarian Cancer
Authors: Chandra Phool , Sachan Neetu , Pal Dilipkumar
Published: February 2021

A serine/threonine-protein kinase, recognized as Glycogen Synthase Kinase-3 (GSK-3),
is documented as a regulator of assorted cellular roles. GSK-3 activates by phosphorylation and
thereby controls the action of many physiological, messenger, and membrane-bound structures.
GSK-3α and GSK-3β are two vastly homologous forms of GSK-3 in mammals. Recent information
has recommended that GSK-3β is a constructive controller of cancer cell proliferation and a
promising key target against cancer cells. GSK-3 is overexpressed in various tumor types, including
ovarian tumors. In human breast carcinoma, it has been revealed that the overexpression of
GSK-3β was linked with breast cancer patients. The inhibition of GSK-3 or inhibitors of GSK-3 is
a promising therapeutic tactic to overcome breast and ovarian cancer. This article features an important
aspect of inhibitors of Glycogen Synthase Kinase-3 as a new lead for treating breast and
ovarian Cancer.
Molecular Elucidation and Therapeutic Targeting for Combating
COVID-19: Current Scenario and Future Prospective
Authors: Suchita Wamankar , Tilotma Sahu , Saurabh Shrivastava , Abhishek Kumar , Sagar Sahu , Lokesh Kumar
Published: February 2021

:

A corona virus disease 2019 (COVID-19) is a contagious disease which is caused by a novel corona virus.
Human corona virus (HCoV) recognized as one of the most rapidly evolving viruses owing to its high genomic nucleotide
substitution rates and recombination. Among the severe acute respiratory syndrome (SARS) and Middle-East respiratory
syndrome (MERS), COVID-19 has spread more rapidly and increased the level of globalization and adaptation of the virus
in every environmental condition due to their high rate of molecular diversity. The whole article highlights the general
characteristics of corona virus, their molecular diversity, and molecular protein targeting against COVID-19 with their
newer approaches. Through this review, an attempt has made to critically evaluate the recent advances and future aspects
helpful to the treatment of COVID-19 based on the present understanding of SARS-CoV-2 infections, which may help offer
new insights and potential therapeutic targets for the treatment of the COVID-19.
Molecular Diversity Assessment using Chemotypes
Authors: Villar Hugo O. , Mandayan Raghav , Hansen Mark R.
Published: February 2021

Background:

Many techniques to design chemical libraries for screening have been put
forward over time. General use libraries are still important when screening against novel targets,
and their design has relied on the use of molecular descriptors. In contrast, chemotype or scaffold
analysis has been used less often.

Objective:

We describe a simple method to assess chemical diversity based on counts of the chemotypes
that offers an alternative to model chemical diversity. We describe a simple method to assess
chemical diversity based on counts of the chemotypes that offers an alternative to model chemical
diversity based on computed molecular properties. We show how chemotype counts can be used to
evaluate the diversity of a library and compare diversity selection algorithms. We demonstrate an
efficient compound selection algorithm based on chemotype analysis.

Methods:

We use automated chemotype perception algorithms and compare them to traditional
techniques for diversity analysis to check their effectiveness in designing diverse libraries for
screening.

Results:

The best type of molecular fingerprints for diversity selection in our analysis are extended
circular fingerprints, but they can be outperformed by the use of a chemotype diversity algorithm,
which can be more intuitive than traditional techniques based on molecular descriptors. Chemotype-
-based algorithms retrieve a larger share of the chemotypes contained in a library when picking a
subset of the chemicals in a collection.

Conclusions:

Chemotype analysis offers an alternative for the generation of a general-purpose
screening library as it maximizes the number of chemotypes present in a subset with the smallest
number of compounds. The applications of methods based on chemotype analysis that does not resort
to the use of molecular descriptors are a very promising but seldom explored area of chemoinformatics.