bluuebunny/crossref_metadata_2025 huggingface dataset:
Reviews Based on the Reconfigurable Intelligent Surface Technical Issues
Authors: Hong Ic-Pyo
Published: November 2023

Reconfigurable intelligent surfaces (RISs) are programmable metasurface structures that can control the propagation of electromagnetic waves by changing the electrical and magnetic properties of the surface. They can be used to intelligently reconfigure the wireless environment to improve the capacity and coverage of wireless networks. In recent years, numerous theoretical innovations and prototype tests have demonstrated that the RIS has the advantages of low cost, low power consumption, and easy deployment, and creates many potential opportunities and broad application prospects in 5G and future 6G networks. In this paper, starting from the technological development of RISs, we discussed the technical issues of RISs. The standardization of RISs, types of RISs according to operation modes, channel modeling, considerations for hardware implementation, differences from existing communication modules and the need for active RIS implementation, noise and power characteristics to ensure the efficiency of RISs, and performance parameters of RISs and field test results of RISs in indoor and outdoor environments were reviewed. By resolving the current technical issues of RISs, it is expected that RISs will be successfully used for B5G/6G communication through commercialization.
Crypto-Ransomware: A Revision of the State of the Art, Advances and Challenges
Authors: Gómez Hernández José Antonio , García Teodoro Pedro , Magán Carrión Roberto , Rodríguez Gómez Rafael
Published: November 2023

According to the premise that the first step to try to solve a problem is to deepen our knowledge of it as much as possible, this work is mainly aimed at diving into and understanding crypto-ransomware, a very present and true-world digital pandemic, from several perspectives. With this aim, this work contributes the following: (a) a review of the fundamentals of this security threat, typologies and families, attack model and involved actors, as well as lifecycle stages; (b) an analysis of the evolution of ransomware in the past years, and the main milestones regarding the development of new variants and real cases that have occurred; (c) a study of the most relevant and current proposals that have appeared to fight against this scourge, as organized in the usual defence lines (prevention, detection, response and recovery); and (d) a discussion of the current trends in ransomware infection and development as well as the main challenges that necessarily need to be dealt with to reduce the impact of crypto-ransomware. All of this will help to better understand the situation and, based on this, will help to develop more adequate defence procedures and effective solutions and tools to defeat attacks.
The Effect of Hot Wind on Needle and Stem Water Status: Response Strategies in Resprouting and Non-Resprouting Pine Species
Authors: Pita Pilar , López Rosana , Gil Luis
Published: November 2023

High temperatures threaten tree survival and regeneration. A few pine species, such as Pinus oocarpa and Pinus canariensis, resprout after complete defoliation, a likely consequence of evolving in volcanic environments. Pinus pinea and Pinus pinaster rely on other mechanisms to survive wildfires. We hypothesized that the needle water potential (Ψ) and needle osmotic potential (Ψs) would decrease more under hot wind in resprouting species, a strategy of needle sacrifice in accordance with the hydraulic segmentation hypothesis. We submitted two-year-old seedlings to a two-phase hot wind treatment, consisting of one hour at 39 °C followed by five minutes at 70 °C. Phase 2 killed all needles. In non-resprouting species, Ψ decreased steeply at the beginning of Phase 1 and remained between −2 MPa and −4 MPa afterward, maintaining the loss of stem hydraulic conductance below the 50% threshold. On average, resprouting species had 15% lower wood densities and kept 51% higher stem water contents than non-resprouting species after Phase 2. The loss of hydraulic conductance did not affect resprouting. The increase in hydraulic conductance toward the base of the stem was lowest in P. canariensis, suggesting a lower degree of conduit tapering in the only species that had not undergone heteroblastic change. We measured the lowest Ψ and highest Ψs in the most xeric P. canariensis and the opposite in the most mesic P. oocarpa, highlighting the roles of xylary and extra-xylary hydraulic resistances in compartmentalizing the needle to preserve the stem. The measurement of both Ψ and Ψs allowed us to characterize the strategies of response to hot wind in resprouting and non-resprouting pine species.
Impregnation of Medium-Density Fiberboard Residues with Phase Change Materials for Efficient Thermal Energy Storage
Authors: Rodríguez Gustavo E. , Bustos Ávila Cecilia , Romero Romina , Cloutier Alain
Published: November 2023

The wood-based panel industry generates a significant amount of solid residues in its production activities, including medium-density fiberboard (MDF) molding manufacturing. These residues consist of fine fibers measuring between 0.15 mm and 1.19 mm in length. A large proportion of them currently needs to be utilized, mainly due to the problem of excessive accumulation. They can be reused as raw material for manufacturing new products by adopting a circular economy approach. Their thermal properties can also be enhanced by impregnating them with phase change materials (PCMs). This research aims to develop a process for impregnating MDF panel residues (R) with PCMs to obtain shape-stabilized compounds capable of storing thermal energy. Three different commercially available PCMs were used. They were incorporated in the MDF residues by vacuum impregnation. The morphology, chemical structure, thermal stability, and phase change properties of the compounds obtained were studied by scanning electron microscopy (SEM), Fourier-transform infrared (FTIR) spectrometry, thermogravimetric analysis (TGA), and differential scanning calorimetry (DSC), respectively. The SEM images indicated the PCM filled the empty spaces in the porous surface of the residue fibers to form shape-stabilized compounds. The FTIR spectrometry results indicated the compounds still exhibited characteristic peaks corresponding to both the MDF residues and the PCMs. No chemical reaction was observed between the two components. Moreover, according to the TGA results, the compounds produced exhibit high thermal stability. The R+PCM1 compound had the highest latent heat capacity of all the compounds developed in this study, reaching a maximum of 57.8 J⋅g−1, and a phase change temperature comparable to that of PCM1. This better thermal performance could be attributed to the compounds having a higher encapsulation ratio (31.4%) than the other compounds developed. Furthermore, the R+PCM1 compound had an absorption capacity of 142.8%. This study, therefore, unveiled a promising alternative for storing thermal energy and valorizing solid MDF residues.
Young Women’s Attitudes and Concerns Regarding Pornography and Their Sexual Experiences: A Qualitative Approach
Authors: Fernández-Ruiz Mónica , López-Entrambasaguas Olga María , Martínez-Linares Jose Manuel , Granero-Molina José
Published: November 2023

This study explores female university students’ attitudes toward and concerns about pornography, based on their experience watching it and on sexual encounters with men. It used a qualitative descriptive design. Individual semi-structured interviews were conducted with 22 participants between March and April 2020. Thematic data analysis was performed using COREQ reporting guidelines. Three themes emerged from the data: (1) the sexual learning process, (2) the role of pornography in women’s sexuality, and (3) sexual experiences. Participants reported how they learned about sexuality and how pornography influenced sexual experiences. Self-esteem issues and societal norms regarding hair removal and difficulty saying “no” to unwanted or humiliating sexual practices were found. The young women were not comfortable with women’s representations in mainstream pornography. They blamed pornography for negative sexual experiences and claimed it influenced them and young men. Participants usually assumed submissive roles during sex and permitted aggressive sexual behaviors. The study reveals valuable information on how young women learn about sex and their difficulty in refusing unwanted sexual activities and even aggressive practices. Sexual education programs should include assertiveness training to improve sexual health, consent, and well-being.
AML under the Scope: Current Strategies and Treatment Involving FLT3 Inhibitors and Venetoclax-Based Regimens
Authors: Milnerowicz Szymon , Maszewska Julia , Skowera Paulina , Stelmach Magdalena , Lejman Monika
Published: November 2023

Acute myeloid leukemia (AML) is a disease that mainly affects elderly patients who are more often unfit for intensive chemotherapy (median age of diagnosis is 68). The regimens, including venetoclax, a highly specific BCL-2 (B-cell lymphoma-2) inhibitor, are a common alternative because of their safer profile and fewer side effects. However, the resistance phenomenon of leukemic cells necessitates the search for drugs that would help to overcome the resistance and improve treatment outcomes. One of the resistance mechanisms takes place through the upregulation of MCL-1 and BCL-XL, preventing BAX/BAK-driven MOMP (mitochondrial outer membrane permeabilization), thus stopping the apoptosis process. Possible partners for BCL-2 inhibitors may include inhibitors from the FLT3i (FMS-like tyrosine kinase-3 inhibitor) group. They resensitize cancer cells through the downregulation of MCL-1 expression in the FLT3 mutated cells, resulting in the stronger efficacy of BCL-2 inhibitors. Also, they provide an additional pathway for targeting the clonal cell. Both preclinical and clinical data suggest that the combination might show a synergistic effect and improve patients’ outcomes. The aim of this review is to determine whether the combination of venetoclax and FLT3 inhibitors can impact the therapeutic approaches and what other agents they can be combined with.
A Comparative Study between Onion Peel Extracts, Free and Complexed with β-Cyclodextrin, as a Natural UV Filter to Cosmetic Formulations
Authors: Messias Mariana A. , Ferreira Sara M. , Tavares Loleny , Santos Lúcia
Published: November 2023

The growing concern regarding the adverse effects of synthetic UV filters found in sunscreens has spurred significant attention due to their potential harm to aquatic ecosystems and human health. To address this, the present study aimed to extract and microencapsulate sensitive bioactive compounds derived from by-product onion peel (OP) by molecular inclusion using β-cyclodextrin as the wall material. Identification and quantification of bioactive compounds within the extract were conducted through high-performance liquid chromatography (HPLC-DAD) analysis, revealing quercetin and resveratrol as the primary constituents. The photoprotection capacity, evaluated by the sun protection factor (SPF), revealed a protection factor comparable to the value for a synthetic UV filter. The produced microparticles presented high antioxidant capacity, significant photoprotection capacity, encapsulation efficiency of 91.8%, mean diameter of 31 μm, and polydispersity of 2.09. Furthermore, to comprehensively evaluate the performance of OP extract and its potential as a natural UV filter, five O/W emulsions were produced. Results demonstrated that microparticles displayed superior ability in maintaining SPF values over a five-week period. Photoprotection evaluation–skin reactivity tests revealed that both extract and microparticles absorb UV radiation in other regions of UV radiation, revealing their potential to be used as a natural UV filter to produce a sustainable and eco-friendly value-added sunscreen.
Neuromodulators as Interdomain Signaling Molecules Capable of Occupying Effector Binding Sites in Bacterial Transcription Factors
Authors: Purtov Yuri A. , Ozoline Olga N.
Published: November 2023

Hormones and neurotransmitters are important components of inter-kingdom signaling systems that ensure the coexistence of eukaryotes with their microbial community. Their ability to affect bacterial physiology, metabolism, and gene expression was evidenced by various experimental approaches, but direct penetration into bacteria has only recently been reported. This opened the possibility of considering neuromodulators as potential effectors of bacterial ligand-dependent regulatory proteins. Here, we assessed the validity of this assumption for the neurotransmitters epinephrine, dopamine, and norepinephrine and two hormones (melatonin and serotonin). Using flexible molecular docking for transcription factors with ligand-dependent activity, we assessed the ability of neuromodulators to occupy their effector binding sites. For many transcription factors, including the global regulator of carbohydrate metabolism, CRP, and the key regulator of lactose assimilation, LacI, this ability was predicted based on the analysis of several 3D models. By occupying the ligand binding site, neuromodulators can sterically hinder the interaction of the target proteins with the natural effectors or even replace them. The data obtained suggest that the direct modulation of the activity of at least some bacterial transcriptional factors by neuromodulators is possible. Therefore, the natural hormonal background may be a factor that preadapts bacteria to the habitat through direct perception of host signaling molecules.
Genome-Wide Identification and Involvement in Response to Biotic and Abiotic Stresses of lncRNAs in Turbot (Scophthalmus maximus)
Authors: Zheng Weiwei , Chen Yadong , Wang Yaning , Chen Songlin , Xu Xi-wen
Published: November 2023

Long non-coding RNAs (lncRNAs) play crucial roles in a variety of biological processes, including stress response. However, the number, characteristics and stress-related expression of lncRNAs in turbot are still largely unknown. In this study, a total of 12,999 lncRNAs were identified at the genome-wide level of turbot for the first time using 24 RNA-seq datasets. Sequence characteristic analyses of transcripts showed that lncRNA transcripts were shorter in average length, lower in average GC content and in average expression level as compared to the coding genes. Expression pattern analyses of lncRNAs in 12 distinct tissues showed that lncRNAs, especially lincRNA, exhibited stronger tissue-specific expression than coding genes. Moreover, 612, 1351, 1060, 875, 420 and 1689 differentially expressed (DE) lncRNAs under Vibrio anguillarum, Enteromyxum scophthalmi, and Megalocytivirus infection and heat, oxygen, and salinity stress conditions were identified, respectively. Among them, 151 and 62 lncRNAs showed differential expression under various abiotic and biotic stresses, respectively, and 11 lncRNAs differentially expressed under both abiotic and biotic stresses were selected as comprehensive stress-responsive lncRNA candidates. Furthermore, expression pattern analysis and qPCR validation both verified the comprehensive stress-responsive functions of these 11 lncRNAs. In addition, 497 significantly co-expressed target genes (correlation coefficient (R) > 0.7 and q-value < 0.05) for these 11 comprehensive stress-responsive lncRNA candidates were identified. Finally, GO and KEGG enrichment analyses indicated that these target genes were enriched mainly in molecular function, such as cytokine activity and active transmembrane transporter activity, in biological processes, such as response to stimulus and immune response, and in pathways, such as protein families: signaling and cellular processes, transporters and metabolism. These findings not only provide valuable reference resources for further research on the molecular basis and function of lncRNAs in turbot but also help to accelerate the progress of molecularly selective breeding of stress-resistant turbot strains or varieties.
Combining Minimally Invasive Direct Coronary Artery Bypass Grafting with Transapical Aortic Valve Implantation—The Next Level Heart Team Approach
Authors: Miazza Jules , Vasiloi Ion , Koechlin Luca , Gahl Brigitta , Santer David , Berdajs Denis , Nestelberger Thomas , Kaiser Christoph , Eckstein Friedrich , Reuthebuch Oliver
Published: November 2023

We present the results of a combined approach for transapical aortic valve replacement and minimally invasive coronary artery bypass grafting (taTAVI-MIDCAB) in patients with combined aortic stenosis and coronary artery disease. Background: For patients presenting with aortic stenosis and coronary artery disease, a simultaneous procedure addressing both diseases is recommended to reduce operative risk. In high-risk patients with hostile femoral or coronary axis, taTAVI-MIDCAB can be an alternative minimally invasive approach, offering the benefits of left interior mammary artery to left anterior descending coronary artery (LIMA-LAD) grafting. Methods: From 2014 to 2022, 10 patients underwent taTAVI-MIDCAB for combined coronary and severe aortic stenosis in the hybrid operation theater at our institution. We assessed perioperative outcomes and follow-up outcomes. Results: The median age was 83 years (81 to 86). The procedure was successfully performed in all patients without conversion to sternotomy. The median length of hospital and intensive care unit stay was 9 days (7 to 16) and 2.5 days (1 to 5), respectively. The median flow over the coronary artery bypass was 31 (22 to 44) mL/min, with a pulsatility index (PI) of 2.4 (2.1 to 3.2). Mild paravalvular leak occurred in 2 patients (10%). There were no neurological events nor acute kidney injury. Pacemaker implantation was required in 1 patient (10%). Conclusions: Simultaneous surgical coronary revascularization and interventional valve implantation in the setting of a hostile femoral and coronary axis appears to be safe and beneficial.
Embracing the Emotion in Emotional Intelligence Measurement: Insights from Emotion Theory and Research
Authors: Mortillaro Marcello , Schlegel Katja
Published: November 2023

Emotional intelligence (EI) has gained significant popularity as a scientific construct over the past three decades, yet its conceptualization and measurement still face limitations. Applied EI research often overlooks its components, treating it as a global characteristic, and there are few widely used performance-based tests for assessing ability EI. The present paper proposes avenues for advancing ability EI measurement by connecting the main EI components to models and theories from the emotion science literature and related fields. For emotion understanding and emotion recognition, we discuss the implications of basic emotion theory, dimensional models, and appraisal models of emotion for creating stimuli, scenarios, and response options. For the regulation and management of one’s own and others’ emotions, we discuss how the process model of emotion regulation and its extensions to interpersonal processes can inform the creation of situational judgment items. In addition, we emphasize the importance of incorporating context, cross-cultural variability, and attentional and motivational factors into future models and measures of ability EI. We hope this article will foster exchange among scholars in the fields of ability EI, basic emotion science, social cognition, and emotion regulation, leading to an enhanced understanding of the individual differences in successful emotional functioning and communication.
The Cellular Accumulation of Vehicle Exhaust Particulates Changes the Acidic pH Environment of Lysosomes in BEAS-2B Airway Epithelial Cells
Authors: Onodera Akira , Shimomura Takuya , Ochi Hirohisa , Sunada Ryuto , Fukutomi Eiko , Hidaka Koushi , Kawai Yuichi
Published: November 2023

Many people are exposed every day to vehicle exhaust particulates (VEPs), which are thought to be taken up by epithelial cells that are the first barrier in our biological defense. The study aim was to investigate how VEPs are processed in the lysosomal degradation system. BEAS-2B airway epithelial cells easily ingest VEPs and have been shown to accumulate in cells for several days, but no elevated cytotoxicity was observed over that time period. An analysis of 3D images confirmed the presence of VEPs in or near lysosomes, and an accumulation of VEPs resulted in an increase in the normal acidic pH in lysosomes and the extracellular release of the lysosomal enzyme β-hexosaminidase. Epithelial cells were thought to activate the lysosome-mediated secretion of extracellular vesicles to avoid damage caused by non-degradable foreign substances, such as VEPs, and as a side reaction, the acidic pH environment of the lysosomes could not be maintained.
Correlation between Landscape Pattern and Net Primary Productivity of Vegetation: A Case Study in the Arid and Semi-Arid Regions of Northwest China
Authors: Xu Congrui , Li Chuanhua
Published: November 2023

Human activities and environmental changes have influenced the changes in landscape patterns, which in turn profoundly impact the variation in net primary productivity (NPP) of vegetation. Understanding the relationship between landscape patterns and NPP is of significant importance for maintaining ecosystem stability and improving the ecological environment. In this study, six land use types in the arid and semi-arid regions of Northwest China were selected, and five landscape pattern indices at the landscape level and four landscape pattern indices at the class level were used. Pearson correlation and multiple linear regression models were employed to analyze the relationship between landscape indices and NPP at a 100 km × 100 km grid scale. The results indicate that there are varying degrees of correlation between landscape pattern indices and NPP from 2001 to 2020, with different levels of variation over the 20-year period. The correlation between indices and NPP is higher at the class level than at the landscape level, and the increase in landscape abundance and fragmentation promotes an increase in NPP. At the landscape level, three landscape indices, namely NP (Number of Patches), PR (Patch Richness), and SHDI (Shannon’s Diversity Index), explain 45.4% of the variation in NPP. At the class level, NP, TE (Total Edge Length), and IJI (Dispersion and Juxtaposition Index) are the main influencing factors for NPP in cropland, forestland, and grassland. Therefore, in ecological governance, it is necessary to consider landscape pattern changes appropriately to maintain ecosystem stability.
Virtual Insights into Natural Compounds as Potential 5α-Reductase Type II Inhibitors: A Structure-Based Screening and Molecular Dynamics Simulation Study
Authors: Shaikh Sibhghatulla , Ali Shahid , Lim Jeong Ho , Ahmad Khurshid , Han Ki Soo , Lee Eun Ju , Choi Inho
Published: November 2023

Androgenic alopecia (AGA) is a dermatological disease with psychosocial consequences for those who experience hair loss. AGA is linked to an increase in androgen levels caused by an excess of dihydrotestosterone in blood capillaries produced from testosterone by 5α-reductase type II (5αR2), which is expressed in scalp hair follicles; 5αR2 activity and dihydrotestosterone levels are elevated in balding scalps. The diverse health benefits of flavonoids have been widely reported in epidemiological studies, and research interest continues to increase. In this study, a virtual screening approach was used to identify compounds that interact with active site residues of 5αR2 by screening a library containing 241 flavonoid compounds. Here, we report two potent flavonoid compounds, eriocitrin and silymarin, that interacted strongly with 5αR2, with binding energies of −12.1 and −11.7 kcal/mol, respectively, which were more significant than those of the control, finasteride (−11.2 kcal/mol). Molecular dynamic simulations (200 ns) were used to optimize the interactions between compounds and 5αR2 and revealed that the interaction of eriocitrin and silymarin with 5αR2 was stable. The study shows that eriocitrin and silymarin provide developmental bases for novel 5αR2 inhibitors for the management of AGA.
Kinetic Modelling the Solid–Liquid Extraction Process of Scandium from Red Mud: Influence of Acid Composition, Contact Time and Temperature
Authors: Daminescu Diana , Duteanu Narcis , Ciopec Mihaela , Negrea Adina , Negrea Petru , Nemeş Nicoleta Sorina , Pascu Bogdan , Lazău Radu , Berbecea Adina
Published: November 2023

Industry represents a fundamental component of modern society, with the generation of massive amounts of industrial waste being the inevitable result of development activities in recent years. Red mud is an industrial waste generated during alumina production using the Bayer process of refining bauxite ore. It is a highly alkaline waste due to the incomplete removal of NaOH. There are several opinions in both the literature and legislation on the hazards of red mud. According to European and national legislation, this mud is not on the list of hazardous wastes; however, if the list of criteria are taken into account, it can be considered as hazardous. The complex processing of red mud is cost-effective because it contains elements such as iron, manganese, sodium, calcium, magnesium, zinc, strontium, lead, copper, cadmium, bismuth, barium and rare earths, especially scandium. Therefore, the selection of an extraction method depends on the form in which the element is present in solution. Extraction is one of the prospective separation and concentration methods. In this study, we evaluated the kinetic modelling of the solid–liquid acid extraction process of predominantly scandium as well as other elements present in red mud. Therefore, three acids (HCl, HNO3 and H2SO4) at different concentrations (10, 20 and 30%) were targeted for the extraction of Sc(III) from solid red mud. Specific parameters of the kinetics of the extraction process were studied, namely the solid:liquid ratio, initial acid concentration, contact time and temperature. The extraction kinetics of Sc(III) with acids was evaluated using first- and second-order kinetic models, involving kinetic parameters, rate constants, saturation concentration and activation energy. The second-order kinetic model was able to describe the mechanism of Sc(III) extraction from red mud. In addition, this study provides an overview on the mechanism of mass transfer involved in the acid extraction process of Sc(III), thereby enabling the design, optimization and control of large-scale processes for red mud recovery.
Achieving High Activity and Long-Term Stability towards Oxygen Evolution in Acid by Phase Coupling between CeO2-Ir
Authors: Kuang Jianren , Li Zhi , Li Weiqiang , Chen Changdong , La Ming , Hao Yajuan
Published: November 2023

The development of efficient and stable catalysts with high mass activity is crucial for acidic oxygen evolution reaction (OER). In this study, CeO2-Ir heterojunctions supported on carbon nanotubes (CeO2-Ir/CNTs) are synthesized using a solvothermal method based on the heterostructure strategy. CeO2-Ir/CNTs demonstrate remarkable effectiveness as catalysts for acidic OER, achieving 10.0 mA cm−2 at a low overpotential of only 262.9 mV and maintaining stability over 60.0 h. Notably, despite using an Ir dosage 15.3 times lower than that of c-IrO2, CeO2-Ir/CNTs exhibit a very high mass activity (2542.3 A gIr−1@1.53 V), which is 58.8 times higher than that of c-IrO2. When applied to acidic water electrolyzes, CeO2-Ir/CNTs display a prosperous potential for application as anodic catalysts. X-ray photoelectron spectrometer (XPS) analysis reveals that the chemical environment of Ir nanoparticles (NP) can be effectively modulated through coupling with CeO2. This modulation is believed to be the key factor contributing to the excellent OER catalytic activity and stability observed in CeO2-Ir/CNTs.
Mesoscopic Simulation of Core–Shell Composite Powder Materials by Selective Laser Melting
Authors: Bao Tao , Tan Yuanqiang , Xu Yangli
Published: November 2023

Mechanical ball milling is used to produce multi-materials for selective laser melting (SLM). However, since different powders have different particle size distributions and densities there is particle segregation in the powder bed, which affects the mechanical properties of the printed part. Core–shell composite powder materials are created and used in the SLM process to solve this issue. Core–shell composite powder materials selective laser melting (CS-SLM) has advanced recently, expanding the range of additive manufacturing applications. Heat storage effects and heat transfer hysteresis in the SLM process are made by the different thermophysical characteristics of the core and the shell material. Meanwhile, the presence of melt flow and migration of unmelted particles in the interaction between unmelted particles and melt complicates the CS-SLM molding process. It is still challenging to investigate the physical mechanisms of CS-SLM through direct experimental observation of the process. In this study, a mesoscopic melt-pool dynamics model for simulating the single-track CS-SLM process is developed. The melting characteristics of nickel-coated tungsten carbide composite powder (WC@Ni) were investigated. It is shown that the powder with a smaller particle size is more likely to form a melt pool, which increases the temperature in the area around it. The impact of process parameters on the size of the melt pool and the distribution of the reinforced particles in the melt pool was investigated. The size of the melt pool is significantly affected more by changes in laser power than by changes in scanning speed. The appropriate control of the laser power or scanning speed can prevent enhanced particle aggregation. This model is capable of simulating CS-SLM with any number of layers and enables a better understanding of the CS-SLM process.
Oral Dysbiosis and Systemic Diseases: A Two-Way Relationship?
Authors: Pisano Massimo
Published: November 2023

The human body consists of its own cells, but also of microorganisms that are found both inside and outside the human body [...]
The Influence of Early Nutrition on Neurodevelopmental Outcomes in Preterm Infants
Authors: Silveira Rita , Corso Andrea , Procianoy Renato
Published: November 2023

Premature infants, given their limited reserves, heightened energy requirements, and susceptibility to nutritional deficits, require specialized care. Aim: To examine the complex interplay between nutrition and neurodevelopment in premature infants, underscoring the critical need for tailored nutritional approaches to support optimal brain growth and function. Data sources: PubMed and MeSH and keywords: preterm, early nutrition, macronutrients, micronutrients, human milk, human milk oligosaccharides, probiotics AND neurodevelopment or neurodevelopment outcomes. Recent articles were selected according to the authors’ judgment of their relevance. Specific nutrients, including macro (amino acids, glucose, and lipids) and micronutrients, play an important role in promoting neurodevelopment. Early and aggressive nutrition has shown promise, as has recognizing glucose as the primary energy source for the developing brain. Long-chain polyunsaturated fatty acids, such as DHA, contribute to brain maturation, while the benefits of human milk, human milk oligosaccharides, and probiotics on neurodevelopment via the gut-brain axis are explored. This intricate interplay between the gut microbiota and the central nervous system highlights human milk oligosaccharides’ role in early brain maturation. Conclusions: Individualized nutritional approaches and comprehensive nutrient strategies are paramount to enhancing neurodevelopment in premature infants, underscoring human milk’s potential as the gold standard of nutrition for preterm infants.
Analysis of Opioid-Related Adverse Events in Japan Using FAERS Database
Authors: Hirai Risako , Uesawa Yoshihiro
Published: November 2023

Adverse events associated with opioid use in palliative care have been extensively studied. However, predicting the occurrence of adverse events based on the specific opioid used remains difficult. This study aimed to comprehensively analyze the adverse events related to µ-opioid receptor stimulation of opioids approved in Japan and investigate the tendencies of adverse event occurrence among different opioids. We utilized the FDA Adverse Event Reporting System database to extract reported adverse events for opioids approved in Japan. Cluster analysis was performed on reporting odds ratios (RORs) of adverse event names among opioids to visualize relationships between opioids and adverse events, facilitating a comparative study of their classifications. We calculated the RORs of adverse events for the target opioids. Cluster analysis based on these RORs resulted in five broad clusters based on the reported adverse events: i.e., strong opioids, weak opioids, loperamide, tapentadol, and remifentanil. This study provides a comprehensive classification of the association between μ-opioid-receptor-stimulating opioids and adverse events.
Waste-Energy Nexus: Cellulose Wood Chips Conjugated Metal Nanoparticles Based Phase Transformation for Improving Thermal Energy Storage Performance
Authors: Hassan Ehssan Ahmed , Tony Maha A.
Published: November 2023

Highlighting waste as a wealth is the future sustainability of the world. Also, using solar energy stored during off-sun periods will overcome the energy crisis. The introduction of wood chip waste for thermal energy storage systems is a sustainable opportunity. Cellulose derived from wood chips was mixed with the environmentally benign magnetite to form a composite (WCM) and mixed with paraffin-based PCM. The composite was characterized through transmission electron microscopy, TEM analysis, scanning electron microscopy, SEM (augmented with dispersive X-ray analysis, EDX). Micrographs, Fourier transform infrared (FTIR), and X-ray diffraction (XRD), which confirmed that the composite material was prepared. Various system proportions of the composite (0.5, 1.0, 2.0, and 4.0%) are embedded in paraffin, and then the thermal system performance is compared. The experimental data revealed that the addition of 2.0 weight percent of composite material showed superior system performance. Also, differential scanning calorimeter (DSC) and TEM analyses of the paraffin-based WCM-composite materials are conducted. The system achieved a heat gain of 87 kJ/min in comparison to 7 kJ/min for 2.0% WCM-PCM and pristine PCM, respectively. Hence, WCM-PCM embedded with waste stream nanoparticles could be suggested as a potential candidate for heating applications.
Avoidance of Riba-Based Loans and Enhancement of Quality of Life: An Indonesian Context Analysis
Authors: Setiawan Romi Adetio
Published: November 2023

Riba (usury) has long been a contentious issue in Islam due to its adverse effects on economic equity and social wellbeing. This paper delves into the intricate relationship between refraining from the use of riba-based loans and the quality of life, with a specific focus on the unique context of Bengkulu, Sumatra, Indonesia. By conducting an extensive analysis of the existing literature and empirical evidence, this study explores the multifaceted dimensions of transitioning away from riba-based loans and their negative consequences. The findings demonstrate that the avoidance of riba-based loans leads to a ripple effect of positive changes and improved mental and physical wellbeing. Furthermore, the ethical dimension underscores the alignment of financial practices with an equitable society and moral values, thereby fostering religious awareness and realization. The paper argues that transitioning away from riba-based loans does not merely serve as a potent catalyst for improving the quality of life exclusively within Muslim communities but extends the impact, transforming the contemporary way of life into a more sustainable and inclusive financial ecosystem. This transformation is achieved by steadfastly prioritizing ethical conduct, spiritual fulfilment, social responsibility, and the equitable sharing of prosperity. This research provides valuable insights for policymakers, practitioners, and researchers who are dedicated to advancing the understanding and implementation of Islamic finance for the betterment of society.
Research on a Non-Synchronous Coordinated Reduction Method for Slopes Based on the Hoek–Brown Criterion and Acoustic Testing Technology
Authors: He Li , Zhao Yongming , Yin Lin , Zhong Dongwang , Xiong Haitao , Chen Shasha , Zhang Xinyue
Published: November 2023

In the process of the evolution of rocky slope instability, the decay deterioration rate of cohesion c and internal friction angle φ are different, and there are also differences in the order and degree of their impact on slope stability; thus, it is of great theoretical value to propose a more practical calculation method for the reduction in slope degradation. This paper combines the Hoek–Brown criterion and an acoustic test method to estimate the mechanical parameters of slope rock mass; the correlative relationship within the double-strength parameter reduction was established by introducing advanced reduction steps (ARS), n, and correlation factor, λ, and a non-synchronous coordinated reduction (NSCR) method for the double parameters of slopes was proposed. Furthermore, methods for determining the comprehensive safety factor (CSF) of slopes during the coordinated reduction of double parameters are comparatively analyzed. The results of the application of engineering examples show that the strength of the slope rock mass is significantly reduced after several blast disturbances, and the equivalent cohesion is reduced from 1.05 MPa to 0.89 MPa, while the internal friction angle is reduced from 25.68° to 21.77°. The CSF calculated using the W. Yuan-2 method is closer to the results of the limit equilibrium method and is suitable for the calculation of the CSF of the NSCR of slopes. The slope CSFs show a trend of first increasing and then decreasing with the increase in n; FS = 3.349 when n = 50, with a relative error of only 8.1% compared to the results calculated using the limit equilibrium method. The NSCR method remediates the blindness of the traditional strength reduction method in double-parameter reduction and ensures that the reduction range of the internal friction angle is no lower than its residual strength limit value, making it practical and feasible for slope stability analysis.
Exploring Indicators for Sustainable Shovel-Ready Projects: A Systematic Literature Review
Authors: Arachchige Harsha Nayanatharangee Dharmarathna Kuruppu , Mohd Ishak Salwa , Kim Ki Pyung
Published: November 2023

This paper presents a rapid systematic review of the indicators and taxonomies of the best practices and governance for construction professionals within small and medium enterprises (SMEs) concerning the management of the sustainability goals of shovel-ready projects and infrastructure stimulus packages. The literature in this field is voluminous and reasonable evidence supports its importance. However, many unknowns exist concerning the association between the sustainability agenda and indicators that are linked to stimulus objectives during the current economic slowdown. This research employed a systematic literature review of peer-reviewed articles. It analysed 660 articles and found that 186 met the study criteria. The research focused on two thematic indicators of sustainability goals in shovel-ready projects, i.e., job creation and environmental aspects. The study primarily examined practices and indicators related to small and medium enterprises (SMEs) addressing sustainability and shovel-ready project objectives. The results suggest that SMEs are more vulnerable during economic downturns and financial crises than larger enterprises. The study also argues that engaging in sustainability objectives or aspects is a competitive strategy for SMEs. Due to time constraints, the article search was limited to peer-reviewed journals published in two academic databases from 2000 to 2021, i.e., Scopus and EBSCO, and considered aspects of job creation and environmental sustainability. Important areas for further research are highlighted as part of the study outcomes. The developed indicators can be tested and verified for construction SMEs to improve sustainability practices concerning shovel-ready project goals and their implementation.
The Characteristics of Rainfall-Runoff Generation and Its Influencing Factors in a Desert Steppe, China
Authors: Hasituya  , Liu Jiahong , Liu Tiejun
Published: November 2023

Understanding the effect of land surface characteristics on rainfall-runoff generation is crucial in mastering the mechanisms of soil and water conservation. To characterize rainfall-runoff generation in desert steppes and to quantify the contribution of different influencing factors, a field-simulated experiment with three land degradation levels and three rainfall intensities (RIs) was conducted in the Inner Mongolia Desert Steppe. The results revealed that rainfall-runoff generation in different degraded plots at various RIs differed significantly. The runoff was generated faster and accumulated larger volumes under high RIs and heavy degradation levels (HDs) in comparison with generation under moderate/light degradation levels (MDs/LDs) and moderate/low RIs. The accumulated runoff over 40 min under a high RI on the HD plot is 153.37 L, which is much larger (0.77 L) than that under a low RI on the LD plot. The result from the structural equation model (SEM) indicated that RI is the most important factor directly driving rainfall-runoff generation, and its standardized path coefficient reached a value of 0.52. The vegetation condition is the second direct factor, with a standardized path coefficient of −0.51. However, the soil water content (SWC) has an indirect impact on rainfall-runoff generation through affecting vegetation conditions. So, interactions also exist between variables such as vegetation and soil. Therefore, the rainfall-runoff generation in the desert steppe may be mitigated through an enhancement of the vegetation and soil properties or through optimizing the interaction relationship between soil and vegetation.
Resource Utilization Potential of Red Mud: A Study on the Micro-Mechanism of the Synergistic Effect of Multiple Solid Waste Filling Materials
Authors: Zhang Jiawei , Yan Guochao , Bai Xuyang , Kong Shaoqi , Li Jiajun , Li Gang , Ge Zhiguo , Huang Jinjing
Published: November 2023

Red mud (RM) is a common industrial byproduct that is characterized by high alkalinity, high pollution, and difficult utilization. In this paper, gangue (CG), flue gas desulfurization gypsum (FGD), and silicate cement (PC) were used to assist red mud in the preparation of red mud-based composite filler material (RMC), aiming at the large-scale resource utilization of RM. The effects of the mass ratio of RM/CG, the mass ratio of FGD/(RM + CG), and the water–solid ratio (WCR) on the multi-angle properties of RMC were investigated and the optimal ratios were determined. The results showed that the RM/CG was 7:1, FGD/(RM + CG) was 4%, and WCR was 0.51 (RMC8), and the system could increase the RM content to 70%. The microstructural analysis of RMC using a specific surface area and porosity analyzer (BET), X-ray diffractometer (XRD), and scanning electron microscope (SEM) showed that its hydration products could remodel the pore structure, encapsulate and cement the coarse and fine particles into a dense matrix, and play a certain alkali reduction role, which revealed the microscopic synergistic mechanism between multiple solid wastes. The study shows that the comprehensive disposal of RM reduces the pollution released into the environment and provides new ideas for the green development of mines.
Temporal and Spatial Distribution of Residual Film in Soil Profile under Continuous Film Mulching
Authors: Yang Xiaoting , Fan Wei , Wu Jinggui , Lv Yan , Zhu Wenyue , Cai Hongguang
Published: November 2023

Plastic pollution in farmland soil has become a significant concern for scientists studying farmland ecosystems. However, the current research focus on the environmental impacts of plastics in soil overlooks crucial factors such as sources, distribution, and persistence. In this study, we examined the distribution of residual film after eight years of film mulching in mid-April 2018. We also assessed changes in spatial distribution from 2018 to 2020. Our findings reveal that eight years of film mulching significantly increased the quantity of agricultural mulch film residues in the soil. The size of residual film fragments varied from 0.25 cm2 to 109 cm2, and the average size, number, and quantity of residues were influenced by soil depth. There was a noticeable downward trend in the quantity of agricultural mulch film residues, decreasing annually by 0.525 kg·ha−1. In contrast, the number of residual films showed an average annual growth rate of 2.13 × 105 p·ha−1. Importantly, we observed a substantial accumulation of residual film fragments below the 10 cm soil layer over time. Fragments ranging from 1–5 cm2 were the most abundant and gradually accumulated in deeper soil layers, enhancing mulching film recovery efficiency. This study provides valuable insights into the influence of mulch cycles on farmland soil profiles, identifying the key locations and size-to-shape ratios of residual films. These findings serve as a theoretical foundation for implementing effective measures to control mulch film pollution in agricultural practices.
Improvement Technologies for Data Imputation in Bioinformatics
Authors: Mochurad Lesia , Horun Pavlo
Published: November 2023

Using existing software technologies for imputing missing genetic data (GD), such as Beagle, HPImpute, Impute, MACH, AlphaPlantImpute, MissForest, and LinkImputeR, has its advantages and disadvantages. The wide range of input parameters and their nonlinear dependence on the target results require a lot of time and effort to find optimal values in each specific case. Thus, optimizing resources for GD imputation and improving its quality is an important current issue for the quality analysis of digitized deoxyribonucleic acid (DNA) samples. This work provides a critical analysis of existing methods and approaches for obtaining high-quality imputed GD. We observed that most of them do not investigate the problem of time and resource costs, which play a significant role in a mass approach. It is also worth noting that the considered articles are often characterized by high development complexity and, at times, unclear (or missing) descriptions of the input parameters for the methods, algorithms, or models under consideration. As a result, two algorithms were developed in this work. The first one aims to optimize the imputation time, allowing for real-time solutions, while the second one aims to improve imputation accuracy by selecting the best results at each iteration. The success of the first algorithm in improving imputation speed ranges from 47% (for small files) to 87% of the time (for medium and larger files), depending on the available resources. For the second algorithm, the accuracy has been improved by about 0.1%. This, in turn, encourages continued research on the latest version of Beagle software, particularly in the selection of optimal input parameters and possibly other models with similar or higher imputation accuracy.
Correction: He et al. In Vivo Imaging Sheds Light on the Susceptibility and Permissivity of Carassius auratus to Cyprinid Herpesvirus 2 According to Developmental Stage. Viruses 2023, 15, 1746
Authors: He Bo , Sridhar Arun , Streiff Cindy , Deketelaere Caroline , Zhang Haiyan , Gao Yuan , Hu Yunlong , Pirotte Sebastien , Delrez Natacha , Davison Andrew J. , Donohoe Owen , Vanderplasschen Alain F. C.
Published: November 2023

In the original publication [...]