bluuebunny/crossref_metadata_2025 huggingface dataset:
The China Question in Italian Foreign Policy
Authors: ROSTAGNI CARLA MENEGUZZI
Published: December 2016

Relying on evidence from the Italian Ministry of Foreign Affairs and on the private archives of both Aldo Moro and Pietro Nenni, this article shows that from the mid-1950s onwards, important politicians—Socialist Pietro Nenni, Christian Democrat Giovanni Gronchi and Liberal Gaetano Martino—worked to encourage economic exchanges between Italy and China, and were linked with the concurrent initiatives of economic actors like Dino Gentili and Enrico Mattei. It also reveals that this gradual but steady process placed the China question firmly on the agenda of Italian parliamentary debates and government programmes as early as 1964. Finally, it shows that, while American diplomacy was still dominated by the Vietnam War and opposed any initiative towards Chinese recognition, in 1969–1970 the long process of rapprochement between Rome and Beijing came to an end. Thanks to Nenni's and Moro's diplomatic action, Italy recognized the People's Republic of China (PRC) before the Americans decided to inaugurate triangular diplomacy and reach out to China.
Laboratory studies on multilingual cognition and further language development
Authors: Sanz Cristina , Cox Jessica G.
Published: December 2016

Multilingualism is now seen as the norm rather than the exception in an age of migration and supranational entities, and where minority language rights and the consequent educational policies have become more common. The field of applied linguistics reflects that transition: second language acquisition (sla) research is slowly being replaced by research on multilingualism, which includes third language (L3) acquisition. Indeed, there is a growing list of studies that are ‘normalizing’ third language acquisition by studying bilinguals learning a new language but not considering bilingualism a variable (e.g. Stafford, Sanz & Bowden 2012; Lado et al. 2014; Pérez-Vidal 2014; Cox & Sanz 2015). In this modern global context, researchers have produced empirical research on L3 acquisition that can be divided into three main categories depending on its focus: (a) classroom studies conducted in bilingual communities and schools with students learning a third language as part of the school curriculum (Cenoz 2013); (b) research on cross-linguistic influence investigating sources of transfer from L1 or L2 into the L3 (e.g. Sanz, Park & Lado 2014) and other possible directions for transfer (González Alonso et al. 2016); and (c) laboratory research – that is, studies outside of classroom or immersion contexts, in which dependent and independent variables can be tightly controlled by the researcher – conducted within a cognitive approach, the focus of this timeline. Despite its potential diminished ecological validity, this last strand is characterized by the robustness of its design and its improved overall validity, and by the manipulation of external conditions and the measurement of internal variables related to cognition.
BAAL/CUP Seminar 2015: (De)Constructing Englishes: Exploring the implications of ontologies of the language for learning, teaching and assessment
Authors: Hall Christopher J
Published: December 2016

This seminar was hosted by York St John University, UK, from 24–26 June 2015, and the co-ordinators were Chris Hall and Rachel Wicaksono (aided by Indu Meddegama, Clare Cunningham, Vicky Crawley, Ruth Ataçocuğu and Christian Sims). The seminar aimed to share diverse understandings of the ontological status of ‘English’ and to stimulate debate regarding the ways in which the language can be most effectively conceptualised for first language and second language learning, teaching and assessment. The seminar was organised around five sessions representing different frameworks. Following each session, an invited discussant highlighted major themes and led a general discussion. Individual papers are reported on below and the conclusion suggests their implications for applied linguistics.
Multirate Adaptive Kalman Filter for Marine Integrated Navigation System
Authors: Davari Narjes , Gholami Asghar , Shabani Mohammad
Published: December 2016

In the conventional integrated navigation system, the statistical information of the process and measurement noises is considered constant. However, due to the changing dynamic environment and imperfect knowledge of the filter statistical information, the process and measurement covariance matrices are unknown and time-varying. In this paper, a multirate adaptive Kalman filter is proposed to improve the performance of the Error State Kalman Filter (ESKF) for a marine navigation system. The designed navigation system is composed of a strapdown inertial navigation system along with Doppler velocity log and inclinometer with different sampling rates. In the proposed filter, the conventional adaptive Kalman filter is modified by adaptively tuning the measurement covariance matrix of the auxiliary sensors that have varying sampling grates based on the innovation sequence. The performance of the proposed filter is evaluated using real measurements. Experimental results show that the average root mean square error of the position estimated by the proposed filter can be decreased by approximately 60% when compared to that of the ESKF.
Higher order symbolic execution for contract verification and refutation
Authors: NGUYÊN PHÚC C. , TOBIN-HOCHSTADT SAM , VAN HORN DAVID
Published: December 2016

We present a new approach to automated reasoning about higher-order programs by endowing symbolic execution with a notion of higher-order, symbolic values. To validate our approach, we use it to develop and evaluate a system for verifying and refuting behavioral software contracts of components in a functional language, which we callsoft contract verification. In doing so, we discover a mutually beneficial relation between behavioral contracts and higher-order symbolic execution. Contracts aid symbolic execution by providing a rich language of specifications serving as a basis of symbolic higher-order values; the theory of blame enables modular verification and leads to the theorem thatverified components can't be blamed; and the run-time monitoring of contracts enablessoftverification whereby verified and unverified components can safely interact. Conversely, symbolic execution aids contracts by providing compile-time verification and automated test case generation from counter-examples to verification. This relation between symbolic exuection and contracts engenders a virtuous cycle encouraging the gradual use of contracts.

Our approach is able to analyze first-class contracts, recursive data structures, unknown functions, and control-flow-sensitive refinements of values, which are all idiomatic in dynamic languages. It makes effective use of off-the-shelf solvers to decide problems without heavy encodings. Counterexample search is sound and relatively complete with respect to a first-order solver for base type values and counter-examples are reported as concrete values, including functions. Therefore, it can form the basis of automated verification and bug-finding tools for higher-order programs. The approach is competitive with a range of existing tools—including type systems, flow analyzers, and model checkers—on their own benchmarks. We have built a prototype to analyze programs written in Racket and report on its effectiveness in verifying and refuting contracts.
Improving the care of people with dementia in general hospitals: evaluation of a whole-system train-the-trainer model
Authors: Sampson Elizabeth L. , Vickerstaff Victoria , Lietz Stephanie , Orrell Martin
Published: December 2016

Background:

There are concerns about the quality of care that people with dementia receive in the general hospital. Staff report a lack of confidence and inadequate training in dementia care.

Methods:

A train-the-trainer model was implemented across eight acute hospital trusts in London via a large academic health and science network. Impact was evaluated using mixed methods. Data were collected at (a) individual level: “Sense of Competence in Dementia Care” (SCID), (b) ward level: Person Interaction and Environment (PIE) observations, (c) organization level: use of specific tools, i.e. “This Is Me,” (d) systems level: numbers and types of staff trained per trust. Results were analyzed with descriptive statistics and paired t-test with thematic framework analysis for PIE observations.

Results:

The number of staff trained per trust ranged from 67 to 650 (total 2,020). A total of 1,688 (85%) baseline questionnaires and 456 (27%) three month follow-up questionnaires were completed. Mean SCID score was 43.2 at baseline and 50.7 at follow-up (paired t-test, p < 0.001). All sub-scales showed a small increase in competence, the largest being for “building relationships.” Organizational level data suggested increased use of carer's passport, “This Is Me” documentation, dementia information leaflets, delirium screening scales, and pathways. PIE observations demonstrated improved staff–patient interactions but little change in hospital environments.

Conclusions:

There was a significant improvement in staffs’ sense of competence in dementia care and the quality of interactions with patients. More hospitals adopted person-centered tools and pathways. Work is required to investigate if these changes improve hospital outcomes for people with dementia.
Knowledge exchange methods in practice: knowing how to design for older adults
Authors: McIntyre Lesley J. , Harrison Ian Ruaraidh
Published: December 2016

Complex design challenges exist in designing for a dynamic and ageing world. Designing for older adults is a timely and important issue. Understanding user requirements is vital and the appropriate exchange of this knowledge is crucial in the pursuit of supportive, sustainable buildings and the longevity of built-environment design.

Capturing reflections from Built Environment Professionals (BEPs) in the UK, this paper investigates the practitioners’ viewpoint on knowledge exchange by specifically focusing on the scenario of designing for the requirements of older people. Thematic analysis of BEP conversations (n=10) and the results from a questionnaire (N=35) are presented.

Findings uncover recommendations towards the enhancement of knowledge exchange. They highlight the fundamentals of good communication, the desire for structured knowledge, the value of contextual guidance, the importance of a visual format for BEPs, and the need for forms of guidance to support client motivations.

The design process can be enabled by equipping practitioners with information about user requirements. Interestingly, it was also found that BEPs find value in direct user-engagement although further support tools for these engagements with building users was desired.

Appropriate exchange of knowledge is essential for effective ‘real-world’ design impact. These findings, built from the scenario of designing for older adults, also apply to the broader context of all guidance used by Built Environment Professionals.
Minority heterotopias: the cortijos of İzmir
Authors: Yucel Sebnem
Published: December 2016

This article introduces the cortijos of İzmir and discusses them as heterotopic places. Originally belonging to the Sephardi Jewish residents of İzmir during the Ottoman times, cortijos were one or two-storey buildings organised around a courtyard, with shared facilities such as toilets and kitchen. The Sephardi inhabitants of cortijos were among the poorest in their community and each family lived in a small single room opening out onto a courtyard. After the immigration of the majority of the Sephardis to Israel in the 1950s, these buildings started to be occupied by equally poor migrants from Eastern Anatolia. In time the demographics of the inhabitants changed even more, replacing families with single, aged and unemployed individuals. Despite changes in the resident profiles, the heterotopic features of cortijos were neither changed nor challenged and only oscillated between heterotopias of crisis and heterotopias of deviation. With a special focus on a documentary photography exhibit on cortijos, titled Kortejo/Aile Evleri, this article discusses their heterotopic features, both in relation to their history and to their current condition. The article concludes by highlighting the new-found public and municipal interest in these buildings after their aestheticisation through photographic images. This new interest suggests an appropriation of the cortijo into the needs and expectations of the consumer society.
The Domínguez House: Alejandro de la Sota's investigation of dwelling
Authors: Santos Sandra Costa
Published: December 2016

The few discussions of Alejandro de la Sota's Domínguez House which currently exist cite a retrospective text, dated 1976, where he developed activity and repose as two distinct images within human dwelling. While the Domínguez House has previously been understood in relation to biological rhythms, this paper presents a different reading of this remarkable project – as a deconstruction and reformulation of the contemporary dwelling, one which challenges the inward-looking understanding of human dwelling as shelter. I therefore propose that Alejandro De la Sota was as an architect with a theoretical agenda, far from the conventional view that his was an empirical approach to architecture.
The unidirectionality of semantic changes in grammaticalization: an experimental approach to the asymmetric priming hypothesis
Authors: HILPERT MARTIN , CORREIA SAAVEDRA DAVID
Published: December 2016

Why is semantic change in grammaticalization typically unidirectional? It is a well-established finding that in grammaticalizing constructions, more concrete meanings tend to evolve into more schematic meanings. Jäger & Rosenbach (2008) appeal to the psychological phenomenon of asymmetric priming in order to explain this tendency. This article aims to evaluate their proposal on the basis of experimental psycholinguistic evidence. Asymmetric priming is a pattern of cognitive association in which one idea strongly evokes another (i.e.paddlestrongly evokeswater), while that second idea does not evoke the first one with the same force (wateronly weakly evokespaddle). Asymmetric priming would elegantly explain why semantic change in grammaticalization tends to be unidirectional, as in the case of Englishbe going to, which has evolved out of the lexical verbgo. As yet, empirical engagement with Jäger & Rosenbach's hypothesis has been limited. We present experimental evidence from a maze task (Forsteret al.2009), in which we test whether asymmetric priming obtains between lexical forms (such asgo) and their grammaticalized counterparts (be going to). On the asymmetric priming hypothesis, the former should prime the latter, but not vice versa. Contrary to the hypothesis, we observe a negative priming effect: speakers who have recently been exposed to a lexical element are significantly slower to process its grammaticalized variant. We interpret this observation as a horror aequi phenomenon (Rohdenburg & Mondorf 2003).
Histopathological Effects on Gills of Nile Tilapia (Oreochromis niloticus, Linnaeus, 1758) Exposed to Pb and Carbon Nanotubes
Authors: Barbieri Edison , Campos-Garcia Janaína , Martinez Diego S. T. , da Silva José Roberto M. C. , Alves Oswaldo Luiz , Rezende Karina F. O.
Published: December 2016

The effect of heavy metal in fish has been the focus of extensive research for many years. However, the combined effect of heavy metals and nanomaterials is still a new subject that needs to be studied. The aim of this study was to examine histopathologic alterations in the gills of Nile tilapia (Oreochromis niloticus) to determine possible effects of lead (Pb), carbon nanotubes, and Pb+carbon nanotubes on their histological integrity, and if this biological system can be used as a tool for evaluating water quality in monitoring programs. For this, tilapia were exposed to Pb, carbon nanotubes and Pb+carbon nanotubes for 4 days. The main alterations observed were epithelial structure, hyperplasia and displacement of epithelial cells, and alterations of the structure and occurrence of aneurysms in the secondary lamella. The most severe alterations were related to the Pb+carbon nanotubes. We conclude that the oxidized multi-walled carbon nanotubes enhanced the acute lead toxicity in Nile tilapias. This work draws attention to the implications of carbon nanomaterials released in the aquatic environment and their interaction with classical pollutants.
Highly compact UWB bandpass filter based on composite right/left-handed transmission line and meander fractal like ring slot in ground
Authors: Shahu Babu Lal , Pal Srikanta , Chattoraj Neela , Upadhyay Dileep Kumar
Published: December 2016

An ultra-wideband (UWB) highly compact bandpass filter with extremely high passband bandwidth is presented. The proposed structure is made using three-staged stepped-impedance lines and a composite right/left-handed transmission line (CRLH-TL) synthesized with meander fractal like ring slot in the ground and series capacitive gap in conductor strip. The capacitive gap in conductor strip and meander fractal like ring slot in the ground plane play major role for controlling the lower and higher cut-off frequencies. The equivalent circuit model of proposed filter is demonstrated and lumped parameters are extracted. A prototype is fabricated to experimentally validate the performance of proposed filter. The proposed UWB filter has extremely wide −10 dB return loss passband bandwidth from 3.14 to 18.26 GHz with relative bandwidth of 142% and insertion loss better than 0.5 dB. Also it achieves a wide upper-stopband from 19.7 to 24.4 GHz with insertion loss better than 13.0 dB, return loss <1.5 dB and sharpened rejection skirts outside the passband at both lower and upper frequency ends. Good agreement is found between simulated and measured results with measured group delay variation in the passband <0.65 ns.
Dealing with Desertion and Gaps in International Humanitarian Law: Changes of Allegiance in the Singapore War Crimes Trials
Authors: CHEAH W.L.
Published: December 2016

By studying British Indian Army [BIA] desertions during World War II, and British postwar trial responses, this paper explores the complicated dimensions of desertion and draws attention to the need for a more explicit and comprehensive approach to desertion in international humanitarian law. The paper focuses on less known British trials dealing with desertion, namely, war crimes trials conducted by the British in Singapore. It examines how these trials dealt with contested interpretations of desertion. Drawing on lessons from these trials, the paper then highlights gaps in today’s international humanitarian law framework, specifically, the need to take into account the realities of desertion, its different permutations, and the difficulties of differentiating between prisoners of war [POWs] and deserters.
Psychometric Qualities of the Creative Process Engagement Scale in a Malaysian Undergraduate Sample
Authors: Tan Chee-Seng , Teo Timothy
Published: December 2016

Abstract. The present study examines the psychometric properties of the Creative Process Engagement Scale (CPES) among Malaysian undergraduates. A total of 377 undergraduates whose ages ranged from 18 to 43 years participated in the study and were presented with the CPES and self-perceived creativity. Confirmatory factor analyses supported the hierarchical four-factor structure of the CPES, which consisted of three first-order factors and one second-order factor. In addition, we found that the CPES has sound internal consistency as well as criterion-related validity. Furthermore, the results of measurement invariance testing supported the hypothesis of equivalent factor loading and intercepts for this hierarchical four-factor structure across gender. Latent mean analysis revealed that female students showed less engagement in creativity-related activities than male students. The findings shed light on the psychometric qualities of the CPES and confirm that the CPES measures involvement in creative activities across gender in undergraduate students.
Targeting cancer‐related inflammation in the era of immunotherapy
Authors: Nakamura Kyohei , Smyth Mark J
Published: December 2016

Recent advances in cancer immunotherapy, particularly immune checkpoint blockade therapy have dramatically changed the therapeutic strategy against advanced malignancies. Still, only a subset of patients shows a good response to any single therapy. Moreover, it remains largely unsolved how we can maintain durable clinical responses, or how we can successfully treat a broader range of cancers by immunotherapy. Growing evidence suggests that the major barrier to more successful cancer immunotherapy is the tumour microenvironment (TME), where chronic inflammation has a predominant role in tumour survival and proliferation, angiogenesis and immunosuppression. Over the past decades, our understanding of cancer‐related inflammation has significantly evolved, and now we have various therapeutic options tailored to the TME. These therapeutic strategies include inhibiting inflammatory mediators or their downstream signalling molecules, blocking the recruitment of myeloid cells, modulating immunosuppressive functions in myeloid cells and re‐educating the TME. In this review, we discuss the role of cancer‐related inflammation as a potential target in the era of immunotherapy.
The dynamics of filament assembly define cytoskeletal network morphology
Authors: Foffano Giulia , Levernier Nicolas , Lenz Martin
Published: December 2016

The actin cytoskeleton is a key component in the machinery of eukaryotic cells, and it self-assembles out of equilibrium into a wide variety of biologically crucial structures. Although the molecular mechanisms involved are well characterized, the physical principles governing the spatial arrangement of actin filaments are not understood. Here we propose that the dynamics of actin network assembly from growing filaments results from a competition between diffusion, bundling and steric hindrance, and is responsible for the range of observed morphologies. Our model and simulations thus predict an abrupt dynamical transition between homogeneous and strongly bundled networks as a function of the actin polymerization rate. This suggests that cells may effect dramatic changes to their internal architecture through minute modifications of their nonequilibrium dynamics. Our results are consistent with available experimental data.
A somatic piRNA pathway in the Drosophila fat body ensures metabolic homeostasis and normal lifespan
Authors: Jones Brian C. , Wood Jason G. , Chang Chengyi , Tam Austin D. , Franklin Michael J. , Siegel Emily R. , Helfand Stephen L.
Published: December 2016

In gonadal tissues, the Piwi-interacting (piRNA) pathway preserves genomic integrity by employing 23–29 nucleotide (nt) small RNAs complexed with argonaute proteins to suppress parasitic mobile sequences of DNA called transposable elements (TEs). Although recent evidence suggests that the piRNA pathway may be present in select somatic cells outside the gonads, the role of a non-gonadal somatic piRNA pathway is not well characterized. Here we report a functional somatic piRNA pathway in the adult Drosophila fat body including the presence of the piRNA effector protein Piwi and canonical 23–29 nt long TE-mapping piRNAs. The piwi mutants exhibit depletion of fat body piRNAs, increased TE mobilization, increased levels of DNA damage and reduced lipid stores. These mutants are starvation sensitive, immunologically compromised and short-lived, all phenotypes associated with compromised fat body function. These findings demonstrate the presence of a functional non-gonadal somatic piRNA pathway in the adult fat body that affects normal metabolism and overall organismal health.
Electronic single-molecule identification of carbohydrate isomers by recognition tunnelling
Authors: Im JongOne , Biswas Sovan , Liu Hao , Zhao Yanan , Sen Suman , Biswas Sudipta , Ashcroft Brian , Borges Chad , Wang Xu , Lindsay Stuart , Zhang Peiming
Published: December 2016

Carbohydrates are one of the four main building blocks of life, and are categorized as monosaccharides (sugars), oligosaccharides and polysaccharides. Each sugar can exist in two alternative anomers (in which a hydroxy group at C-1 takes different orientations) and each pair of sugars can form different epimers (isomers around the stereocentres connecting the sugars). This leads to a vast combinatorial complexity, intractable to mass spectrometry and requiring large amounts of sample for NMR characterization. Combining measurements of collision cross section with mass spectrometry (IM–MS) helps, but many isomers are still difficult to separate. Here, we show that recognition tunnelling (RT) can classify many anomers and epimers via the current fluctuations they produce when captured in a tunnel junction functionalized with recognition molecules. Most importantly, RT is a nanoscale technique utilizing sub-picomole quantities of analyte. If integrated into a nanopore, RT would provide a unique approach to sequencing linear polysaccharides.
Pressure induced enhancement of the magnetic ordering temperature in rhenium(IV) monomers
Authors: Woodall Christopher H. , Craig Gavin A. , Prescimone Alessandro , Misek Martin , Cano Joan , Faus Juan , Probert Michael R. , Parsons Simon , Moggach Stephen , Martínez-Lillo José , Murrie Mark , Kamenev Konstantin V. , Brechin Euan K.
Published: December 2016

Materials that demonstrate long-range magnetic order are synonymous with information storage and the electronics industry, with the phenomenon commonly associated with metals, metal alloys or metal oxides and sulfides. A lesser known family of magnetically ordered complexes are the monometallic compounds of highly anisotropic d-block transition metals; the ‘transformation’ from isolated zero-dimensional molecule to ordered, spin-canted, three-dimensional lattice being the result of through-space interactions arising from the combination of large magnetic anisotropy and spin-delocalization from metal to ligand which induces important intermolecular contacts. Here we report the effect of pressure on two such mononuclear rhenium(IV) compounds that exhibit long-range magnetic order under ambient conditions via a spin canting mechanism, with Tc controlled by the strength of the intermolecular interactions. As these are determined by intermolecular distance, ‘squeezing’ the molecules closer together generates remarkable enhancements in ordering temperatures, with a linear dependence of Tc with pressure.
Strong confinement-induced engineering of the g factor and lifetime of conduction electron spins in Ge quantum wells
Authors: Giorgioni Anna , Paleari Stefano , Cecchi Stefano , Vitiello Elisa , Grilli Emanuele , Isella Giovanni , Jantsch Wolfgang , Fanciulli Marco , Pezzoli Fabio
Published: December 2016

Control of electron spin coherence via external fields is fundamental in spintronics. Its implementation demands a host material that accommodates the desirable but contrasting requirements of spin robustness against relaxation mechanisms and sizeable coupling between spin and orbital motion of the carriers. Here, we focus on Ge, which is a prominent candidate for shuttling spin quantum bits into the mainstream Si electronics. So far, however, the intrinsic spin-dependent phenomena of free electrons in conventional Ge/Si heterojunctions have proved to be elusive because of epitaxy constraints and an unfavourable band alignment. We overcome these fundamental limitations by investigating a two-dimensional electron gas in quantum wells of pure Ge grown on Si. These epitaxial systems demonstrate exceptionally long spin lifetimes. In particular, by fine-tuning quantum confinement we demonstrate that the electron Landé g factor can be engineered in our CMOS-compatible architecture over a range previously inaccessible for Si spintronics.
Direct observation of exceptional points in coupled photonic-crystal lasers with asymmetric optical gains
Authors: Kim Kyoung-Ho , Hwang Min-Soo , Kim Ha-Reem , Choi Jae-Hyuck , No You-Shin , Park Hong-Gyu
Published: December 2016

Although counter-intuitive features have been observed in non-Hermitian optical systems based on micrometre-sized cavities, the achievement of a simplified but unambiguous approach to enable the efficient access of exceptional points (EPs) and the phase transition to desired lasing modes remains a challenge, particularly in wavelength-scale coupled cavities. Here, we demonstrate coupled photonic-crystal (PhC) nanolasers with asymmetric optical gains, and observe the phase transition of lasing modes at EPs through tuning of the area of graphene cover on one PhC cavity and systematic scanning photoluminescence measurements. As the gain contrast between the two identical PhC cavities exceeds the intercavity coupling, the phase transition occurs from the bonding/anti-bonding lasing modes to the single-amplifying lasing mode, which is confirmed by the experimental measurement of the mode images and the theoretical modelling of coupled cavities with asymmetric gains. In addition, we demonstrate active tuning of EPs by controlling the optical loss of graphene through electrical gating.
Nutrient enrichment modifies temperature-biodiversity relationships in large-scale field experiments
Authors: Wang Jianjun , Pan Feiyan , Soininen Janne , Heino Jani , Shen Ji
Published: December 2016

Climate effects and human impacts, that is, nutrient enrichment, simultaneously drive spatial biodiversity patterns. However, there is little consensus about their independent effects on biodiversity. Here we manipulate nutrient enrichment in aquatic microcosms in subtropical and subarctic regions (China and Norway, respectively) to show clear segregation of bacterial species along temperature gradients, and decreasing alpha and gamma diversity toward higher nutrients. The temperature dependence of species richness is greatest at extreme nutrient levels, whereas the nutrient dependence of species richness is strongest at intermediate temperatures. For species turnover rates, temperature effects are strongest at intermediate and two extreme ends of nutrient gradients in subtropical and subarctic regions, respectively. Species turnover rates caused by nutrients do not increase toward higher temperatures. These findings illustrate direct effects of temperature and nutrients on biodiversity, and indirect effects via primary productivity, thus providing insights into how nutrient enrichment could alter biodiversity under future climate scenarios.
Starter formula enriched in prebiotics and probiotics ensures normal growth of infants and promotes gut health: a randomized clinical trial
Authors: Radke Michael , Picaud Jean-Charles , Loui Andrea , Cambonie Gilles , Faas Dirk , Lafeber Harry N. , de Groot Nanda , Pecquet Sophie S. , Steenhout Philippe G. , Hascoet Jean-Michel
Published: December 2016

Background:

Prebiotics and probiotics exert beneficial effects by modulating gut microbiota and immune system. This study evaluates efficacy and safety of an infant formula containing bovine milk-derived oligosaccharides and Bifidobacterium animalis ssp lactis (B. lactis) (CNCM I-3446) on incidence of diarrhea and febrile infections during the first year of life (primary outcome).

Methods:

Full-term infants receiving Test or Control (without bovine milk-derived oligosaccharide and B. lactis) formulae were enrolled in a multicenter, randomized, controlled, and double-blind trial with a reference breastfeeding group. .

Results:

413 infants were assigned between Test (n = 206) and Control (n = 207) formula. There was no significant difference for diarrhea and febrile infections incidence between groups at 6 (odds ratio (95% confidence interval) = 0.56 (0.26–1.15), P = 0.096) and 12 mo (odds ratio = 0.66 (0.38–1.14), P = 0.119). Test formula was well tolerated, anthropometrics parameters were not significantly different between groups and aligned with WHO growth standards up to 12 mo. Data from test group showed that gut microbiota pattern, fecal IgA and stool pH were brought to be closer to those of breastfed infants.

Conclusion:

An infant formula enriched with bovine milk-derived oligosaccharide and B. lactis supports normal infant growth, is well tolerated and improves intestinal health markers. No differences in diarrhea and febrile infection incidence were found in the population studied.
Hematopoietic Stem Cells in Neural-crest Derived Bone Marrow
Authors: Jiang Nan , Chen Mo , Yang Guodong , Xiang Lusai , He Ling , Hei Thomas K. , Chotkowski Gregory , Tarnow Dennis P. , Finkel Myron , Ding Lei , Zhou Yanheng , Mao Jeremy J.
Published: December 2016

Hematopoietic stem cells (HSCs) in the endosteum of mesoderm-derived appendicular bones have been extensively studied. Neural crest-derived bones differ from appendicular bones in developmental origin, mode of bone formation and pathological bone resorption. Whether neural crest-derived bones harbor HSCs is elusive. Here, we discovered HSC-like cells in postnatal murine mandible, and benchmarked them with donor-matched, mesoderm-derived femur/tibia HSCs, including clonogenic assay and long-term culture. Mandibular CD34 negative, LSK cells proliferated similarly to appendicular HSCs, and differentiated into all hematopoietic lineages. Mandibular HSCs showed a consistent deficiency in lymphoid differentiation, including significantly fewer CD229 + fractions, PreProB, ProB, PreB and B220 + slgM cells. Remarkably, mandibular HSCs reconstituted irradiated hematopoietic bone marrow in vivo, just as appendicular HSCs. Genomic profiling of osteoblasts from mandibular and femur/tibia bone marrow revealed deficiencies in several HSC niche regulators among mandibular osteoblasts including Cxcl12. Neural crest derived bone harbors HSCs that function similarly to appendicular HSCs but are deficient in the lymphoid lineage. Thus, lymphoid deficiency of mandibular HSCs may be accounted by putative niche regulating genes. HSCs in craniofacial bones have functional implications in homeostasis, osteoclastogenesis, immune functions, tumor metastasis and infections such as osteonecrosis of the jaw.
Demarcation of Prime Farmland Protection Areas around a Metropolis Based on High-Resolution Satellite Imagery
Authors: Xia Nan , Wang YaJun , Xu Hao , Sun YueFan , Yuan Yi , Cheng Liang , Jiang PengHui , Li ManChun
Published: December 2016

Prime farmland (PF) is defined as high-quality farmland and a prime farmland protection area (PFPA, including related roads, waters and facilities) is a region designated for the special protection of PF. However, rapid urbanization in China has led to a tremendous farmland loss and to the degradation of farmland quality. Based on remote sensing and geographic information system technology, this study developed a semiautomatic procedure for designating PFPAs using high-resolution satellite imagery (HRSI), which involved object-based image analysis, farmland composite evaluation, and spatial analysis. It was found that the HRSIs can provide elaborate land-use information, and the PFPA demarcation showed strong correlation with the farmland area and patch distance. For the benefit of spatial planning and management, different demarcation rules should be applied for suburban and exurban areas around a metropolis. Finally, the overall accuracy of HRSI classification was about 80% for the study area, and high-quality farmlands from evaluation results were selected as PFs. About 95% of the PFs were demarcated within the PFPAs. The results of this study will be useful for PFPA planning and the methods outlined could help in the automatic designation of PFPAs from the perspective of the spatial science.
Allocation strategies of savanna and forest tree seedlings in response to fire and shading: outcomes of a field experiment
Authors: Gignoux Jacques , Konaté Souleymane , Lahoreau Gaëlle , Le Roux Xavier , Simioni Guillaume
Published: December 2016

The forest-savanna ecotone may be very sharp in fire-prone areas. Fire and competition for light play key roles in its maintenance, as forest and savanna tree seedlings are quickly excluded from the other ecosystem. We hypothesized a tradeoff between seedling traits linked to fire resistance and to competition for light to explain these exclusions. We compared growth- and survival-related traits of two savanna and two forest species in response to shading and fire in a field experiment. To interpret the results, we decomposed our broad hypothesis into elementary tradeoffs linked to three constraints, biomass allocation, plant architecture, and shade tolerance, that characterize both savanna and adjacent forest ecosystems. All seedlings reached similar biomasses, but forest seedlings grew taller. Savanna seedlings better survived fire after topkill and required ten times less biomass than forest seedlings to survive. Finally, only savanna seedlings responded to shading. Although results were consistent with the classification of our species as mostly adapted to shade tolerance, competition for light in the open, and fire tolerance, they raised new questions: how could savanna seedlings survive better with a 10-times lower biomass than forest seedlings? Is their shade intolerance sufficient to exclude them from forest understory?
Reconfigurable SDM Switching Using Novel Silicon Photonic Integrated Circuit
Authors: Ding Yunhong , Kamchevska Valerija , Dalgaard Kjeld , Ye Feihong , Asif Rameez , Gross Simon , Withford Michael J. , Galili Michael , Morioka Toshio , Oxenløwe Leif Katsuo
Published: December 2016

Space division multiplexing using multicore fibers is becoming a more and more promising technology. In space-division multiplexing fiber network, the reconfigurable switch is one of the most critical components in network nodes. In this paper we for the first time demonstrate reconfigurable space-division multiplexing switching using silicon photonic integrated circuit, which is fabricated on a novel silicon-on-insulator platform with buried Al mirror. The silicon photonic integrated circuit is composed of a 7 × 7 switch and low loss grating coupler array based multicore fiber couplers. Thanks to the Al mirror, grating couplers with ultra-low coupling loss with optical multicore fibers is achieved. The lowest total insertion loss of the silicon integrated circuit is as low as 4.5 dB, with low crosstalk lower than −30 dB. Excellent performances in terms of low insertion loss and low crosstalk are obtained for the whole C-band. 1 Tb/s/core transmission over a 2-km 7-core fiber and space-division multiplexing switching is demonstrated successfully. Bit error rate performance below 10−9 is obtained for all spatial channels with low power penalty. The proposed design can be easily upgraded to reconfigurable optical add/drop multiplexer capable of switching several multicore fibers.
Detailed analysis of charge transport in amorphous organic thin layer by multiscale simulation without any adjustable parameters
Authors: Uratani Hiroki , Kubo Shosei , Shizu Katsuyuki , Suzuki Furitsu , Fukushima Tatsuya , Kaji Hironori
Published: December 2016

Hopping-type charge transport in an amorphous thin layer composed of organic molecules is simulated by the combined use of molecular dynamics, quantum chemical, and Monte Carlo calculations. By explicitly considering the molecular structure and the disordered intermolecular packing, we reasonably reproduce the experimental hole and electron mobilities and their applied electric field dependence (Poole–Frenkel behaviour) without using any adjustable parameters. We find that the distribution of the density-of-states originating from the amorphous nature has a significant impact on both the mobilities and Poole–Frenkel behaviour. Detailed analysis is also provided to reveal the molecular-level origin of the charge transport, including the origin of Poole–Frenkel behaviour.
Overexcited MaxiK and KATP channels underlie obstructive jaundice-induced vasoconstrictor hyporeactivity of arterial smooth muscle
Authors: Yuan Ya-wei , Wang Long , Lu Zhan-ying , Long Yue , Jiao Ying-fu , Xia Qiang , Wen Da-xiang , Yu Wei-feng
Published: December 2016

Substantial evidence has shown that obstructive jaundice can induce vascular hyporesponsiveness. The present study was designed to investigate mechanisms of MaxiK channel and KATP underlying cholestasis-induced vascular dysfunction. The isolated thoracic aorta was used to explore norepinephrine (NE)-induced contraction. The function of MaxiK and KATP channels were investigated using whole-cell patch clamp recording. Compared with Sham group, NE-induced vascular contraction was blunted after bile duct ligation (BDL), which could not be ameliorated significantly after endothelial denudation. Charybdotoxin and glibenclamide induced a more pronounced recovery from vascular hyporesponsiveness to NE in BDL group compared with Sham group. BDL significantly promoted the charybdotoxin sensitive MaxiK current and KATP current in isolated aortic smooth muscle cells. In addition, the expression of auxiliary subunits (MaxiK-β1 and SUR2B) rather pore-forming subunits (MaxiK-α and Kir6.1) was significantly up-regulated after BDL. These findings suggest that MaxiK and KATP channels play an important role in regulating vascular hyporesponsiveness in BDL rats.
Mechanistic Study of Tetrahydrofuran- acetogenins In Triggering Endoplasmic Reticulum Stress Response-apotoposis in Human Nasopharyngeal Carcinoma
Authors: Juang Shin-Hun , Chiang Chang-Ying , Liang Fong-Pin , Chan Hsiu-Hui , Yang Jai-Sing , Wang Shih-Hao , Lin Yu-Chin , Kuo Ping-Chung , Shen Meng-Ru , Thang Tran Dinh , Nguyet Bui Thi Minh , Kuo Sheng-Chu , Wu Tian-Shung
Published: December 2016

For past three decades, numerous studies have elucidated the antiproliferative effects of acetogenins in hopes of developing a new class of clinical anticancer agents. However, clear and definitive action mechanisms of acetogenins were less clarified. In the present study, three tetrahydrofuran (THF)-containing acetogenins were found to have potent and selective antiproliferative activity against human nasopharyngeal carcinoma (NPC) cell lines and their methotrexate-resistant counterparts. The THF-containing acetogenins induced G2/M phase arrest, mitochondrial damage and apoptosis, and increased cytosolic and mitochondrial Ca2+ in NPCs. Microarray analysis of NPC-TW01 cells treated with squamostatin A, a non-adjacent bis-THF acetogenin, demonstrated an increased endoplasmic reticulum (ER)-stress response (ESR). Enhanced ESR in squamostatin A-treated cells was confirmed by real-time PCR, Western blot and shRNA gene knockdown experiments. Although our results showed that squamostatin A-induced ESR was independent of extracellular Ca2+, the presence of extracellular Ca2+ enhanced the antiproliferative effect of acetogenins. In vivo analyses demonstrated that squamostatin A showed good pharmacokinetic properties and significantly retarded NPC tumor growth in the xenograft mouse model. Conclusively, our work demonstrates that acetogenins are effective and selective inducers of the ESR that can block NPC proliferation, and illustrate a previously unappreciated antitumor mechanism of acetogenins that is effective against nasopharyngeal malignancies.
Extraction of nano-silicon with activated carbons simultaneously from rice husk and their synergistic catalytic effect in counter electrodes of dye-sensitized solar cells
Authors: Ahmad Waqar , bahrani Majid Raissan Al , Yang Zhichun , Khan Jahangeer , Jing Wenkui , Jiang Fan , Chu Liang , Liu Nishuang , Li Luying , Gao Yihua
Published: December 2016

The extraction of renewable energy resources particularly from earth abundant materials has always been a matter of significance in industrial products. Herein, we report a novel simultaneous extraction of nano-silicon with activated carbons (nano-Si@ACs) from rice husk (RH) by chemical activation method. As-extracted nano-Si@ACs is then used as an energy harvesting materials in counter electrodes (CEs) of dye-sensitized solar cells (DSSCs). The morphology, structure and texture studies confirm the high surface area, abundant active sites and porous structure of nano-Si@ACs. Electrochemical impedance spectroscopy and cyclic voltammetry analyses reveal that the nano-Si@ACs is highly beneficial for fast I3− reduction and superior electrolyte diffusion capability. The nano-Si@ACs CE based DSSC exhibits enhanced power conversion efficiency of (8.01%) in contrast to pristine Pt CE (7.20%). These favorable results highlight the potential application of RH in low-cost, high-efficiency and Pt-free DSSCs.
Correction: Corrigendum: miR-200 family controls late steps of postnatal forebrain neurogenesis via Zeb2 inhibition
Authors: Beclin Christophe , Follert Philipp , Stappers Elke , Barral Serena , Coré Nathalie , Chevigny Antoine de , Magnone Virginie , Lebrigand Kévin , Bissels Ute , Huylebroeck Danny , Bosio Andreas , Barbry Pascal , Seuntjens Eve , Cremer Harold
Published: December 2016

Scientific Reports 6: Article number: 35729; published online: 21 October 2016; updated: 21 December 2016.
Identification of a TNF-α inducer MIC3 originating from the microneme of non-cystogenic, virulent Toxoplasma gondii
Authors: Qiu Jingfan , Wang Lijuan , Zhang Rong , Ge Ke , Guo Hongfei , Liu Xinjian , Liu Jinfeng , Kong Delong , Wang Yong
Published: December 2016

Toxoplasma gondii is an opportunistic parasite with avirulent cystogenic and highly virulent non-cystogenic isolates. Although non-cystogenic strains are considered the most virulent, there are also marked genetic and virulence differences among these strains. Excretory-secretory antigens (ESAs) of T. gondii are critical for the invasion process and the immune response of the host. To better understand the differences in virulence between non-cystogenic T. gondii isolates, we studied ESAs of the RH strain (Type I), and the very prevalent in China, but less virulent TgCtwh3 strain (Chinese 1). ESAs of RH and TgCtwh3 triggered different levels of TNF-α production and macrophage M1 polarization. Using iTRAQ analysis, 27 differentially expressed proteins originating from secretory organelles and surface were quantified. Of these proteins, 11 microneme-associated proteins (MICs), 6 rhoptry proteins, 2 dense granule proteins and 5 surface proteins were more abundant in RH than in TgCtwh3. The protein-protein correlation network was employed to identify the important functional node protein MIC3, which was upregulated 5-fold in RH compared with TgCtwh3. MIC3 was experimentally confirmed to evoke a TNF-α secretory response, and it also induced macrophage M1 polarization. This result suggests that MIC3 is a potentially useful immunomodulator that induces TNF-α secretion and macrophage M1 polarization.