bluuebunny/crossref_metadata_2025 huggingface dataset:
The Apelin–Apelin Receptor Axis Triggers Cholangiocyte Proliferation and Liver Fibrosis During Mouse Models of Cholestasis
Authors: Chen Lixian , Zhou Tianhao , White Tori , O'Brien April , Chakraborty Sanjukta , Liangpunsakul Suthat , Yang Zhihong , Kennedy Lindsey , Saxena Romil , Wu Chaodong , Meng Fanyin , Huang Qiaobing , Francis Heather , Alpini Gianfranco , Glaser Shannon
Published: September 2020

Background and Aims

Apelin (APLN) is the endogenous ligand of its G protein–coupled receptor, apelin receptor (APJ). APLN serum levels are increased in human liver diseases. We evaluated whether the APLN–APJ axis regulates ductular reaction and liver fibrosis during cholestasis.

Approach and Results

We measured the expression of APLN and APJ and serum APLN levels in human primary sclerosing cholangitis (PSC) samples. Following bile duct ligation (BDL) or sham surgery, male wild‐type (WT) mice were treated with ML221 (APJ antagonist) or saline for 1 week. WT and APLN−/− mice underwent BDL or sham surgery for 1 week. Multidrug resistance gene 2 knockout (Mdr2−/−) mice were treated with ML221 for 1 week. APLN levels were measured in serum and cholangiocyte supernatants, and cholangiocyte proliferation/senescence and liver inflammation, fibrosis, and angiogenesis were measured in liver tissues. The regulatory mechanisms of APLN–APJ in (1) biliary damage and liver fibrosis were examined in human intrahepatic biliary epithelial cells (HIBEpiCs) treated with APLN and (2) hepatic stellate cell (HSC) activation in APLN‐treated human HSC lines (HHSteCs). APLN serum levels and biliary expression of APLN and APJ increased in PSC samples. APLN levels were higher in serum and cholangiocyte supernatants from BDL and Mdr2−/− mice. ML221 treatment or APLN−/− reduced BDL‐induced and Mdr2−/−‐induced cholangiocyte proliferation/senescence, liver inflammation, fibrosis, and angiogenesis. In vitro, APLN induced HIBEpiC proliferation, increased nicotinamide adenine dinucleotide phosphate oxidase 4 (Nox4) expression, reactive oxygen species (ROS) generation, and extracellular signal–regulated kinase (ERK) phosphorylation. Pretreatment of HIBEpiCs with ML221, diphenyleneiodonium chloride (Nox4 inhibitor), N‐acetyl‐cysteine (NAC, ROS inhibitor), or PD98059 (ERK inhibitor) reduced APLN‐induced cholangiocyte proliferation. Activation of HHSteCs was induced by APLN but reduced by NAC.

Conclusions

The APLN–APJ axis induces cholangiocyte proliferation through Nox4/ROS/ERK‐dependent signaling and HSC activation through intracellular ROS. Modulation of the APLN–APJ axis may be important for managing cholangiopathies.
Evaluation of dietary pattern in early pregnancy using the FIGO Nutrition Checklist compared to a food frequency questionnaire
Authors: Tsoi Kit Ying , Chan Ruth S.M. , Li Liz Sin , McAuliffe Fionnuala M. , Hanson Mark A. , Tam Wing Hung , Ma Ronald C.W.
Published: September 2020

Objective

To evaluate the reliability and utility of the FIGO Nutrition Checklist to identify dietary and nutritional inadequacy in early pregnancy by comparing it against nutritional indicators and dietary quality indices (Dietary Approaches to Stop Hypertension [DASH] score, Mediterranean Diet Score [MDS], and Dietary Quality Index‐International [DQI‐I]), derived by a locally validated food frequency questionnaire (FFQ).

Methods

A prospective cohort study of healthy Chinese pregnant women randomly recruited between September 2017 and April 2018 at their first antenatal appointment. Women completed the FIGO Nutrition Checklist (translated into Chinese) and the FFQ. Spearman correlation was performed to examine association between the Checklist and dietary quality indices or food and nutrient intakes, calculated based on dietary data from the FFQ.

Results

Of 160 participants, 156 (97.5%) completed both the FIGO Nutrition Checklist and FFQ and were included. There were 148 (95%) women who reported at least one suboptimal dietary behavior using the Checklist. Checklist score was significantly associated with dietary quality indices (DASH ρ=0.344, P<0.001; DQI‐I ρ=0.304, P<0.001; MDS ρ=0.164, P=0.041). The Checklist question on fruit/vegetables was significantly associated with fiber, vitamin C, and fruit and vegetable intake as calculated from the FFQ (0.325 ≤ ρ ≤0.441, P<0.001). The question on dairy intake was significantly associated with intake of calcium, milk and dairy products captured via FFQ (0.576 ≤ ρ ≤0.655, P<0.001).

Conclusion

This study supports the use of the FIGO Nutrition Checklist to identify women with suboptimal dietary quality in early pregnancy.
Melatonin as a potential inhibitor of kidney cancer: A survey of the molecular processes
Authors: Maleki Dana Parisa , Reiter Russel J. , Hallajzadeh Jamal , Asemi Zatollah , Mansournia Mohammad Ali , Yousefi Bahman
Published: September 2020

Studies have shown that despite the decreasing mortality rates of kidney cancer patients, its incidence is increasing. Therefore, a comprehensive re‐evaluation of treatment options is necessary to provide appropriate treatments for the increasing number of patients. Moreover, the side effects caused by surgery, which is the main treatment of this disease, may lead to higher morbidity rates. Consequently, new safer approaches must be examined and considered. Major advancements have been made in the field of targeted agents as well as treatments based on immunotherapy since renal cell carcinoma (RCC) does not respond well to chemotherapy. While the therapeutic options for this cancer are increasing, the resulting complexity of selecting the best strategy for treating the patients is daunting. Moreover, each therapeutic option must be evaluated concerning toxicity, cost, and clinical advantages. Several characteristics, which are beneficial for cancer therapies have been attributed to melatonin. For decades, investigations have explored the application of melatonin in the treatment of cancer; insufficient attention has been paid to this molecule at the clinical level. Melatonin plays a role in cancer therapy due to its anti‐tumor effects as well as by enhancing the efficacy of other drugs as an adjuvant. In this review, we discuss different roles of melatonin in the treatment of kidney cancer. The studies concerned with the applications of melatonin as an adjuvant in the immunotherapy of patients with kidney cancer are summarized. Also, we highlight the apoptotic and anti‐angiogenic effects of melatonin on renal cancer cells which are mediated by different molecules (e.g., HIF‐1 and VEGF, ADAMTS1, and MMP‐9) and signaling pathways (e.g., P56, P52, and JNK). Furthermore, we take a look into available data on melatonin's ability to reduce the toxicities caused by kidney carcinogens, including ochratoxin A, potassium bromate, and Fe‐NTA.
Subclinical Ultrasound Characteristics of Infantile Hemangiomas That May Potentially Affect Involution
Authors: McNab María , García Carolina , Tabak Denise , Aranibar Ligia , Castro Ariel , Wortsman Ximena
Published: September 2020

Objectives

Infantile hemangiomas (IHs) are the most common benign tumors in children. Color Doppler ultrasound is a noninvasive imaging modality that can show subclinical anatomic parameters in a wide range of dermatologic conditions. The purpose of this study was to describe the ultrasound characteristics of IHs and look for subclinical features with the potential to influence the involution and therapeutic response.

Methods

A review of the ultrasound database of children with clinical and ultrasound IH diagnoses was conducted. The clinically reported duration and the ultrasound assessment of the proliferative phase were compared. Descriptive and statistical analyses of qualitative and quantitative parameters of the series were performed. Significance was set at P < .05.

Results

A total of 204 IHs were included. Twenty percent had arteriovenous shunts; 15% had afferent branches from main regional arteries; and almost 30% showed involvement of deep structures. Sixty‐one percent of IHs were in the head and neck. Deep hemangiomas showed significantly thicker lesional vessels. A prolonged proliferative stage was significantly associated with a higher presence of arteriovenous shunts and a higher peak systolic velocity of the arterial vessels (≥15 cm/s) within the lesions.

Conclusions

Color Doppler ultrasound can support the detection of subclinical anatomic features that may potentially influence the involution and response to treatment of IHs. Some of these characteristics may serve as potential markers to predict and manage IHs in prolonged proliferative stages.
Selection of competent oocytes by morphological criteria for assisted reproductive technologies
Authors: Ozturk Saffet
Published: September 2020

Invasive and noninvasive methods are commonly used to select developmentally competent oocytes that can improve the take‐home baby rates in assisted reproductive technology (ART) centers. One of the noninvasive methods conventionally utilized to determine competent oocytes is the morphological analysis of cumulus complex, first polar body, zona pellucida, perivitelline space, meiotic spindle, and ooplasm. Successful fertilization, early embryo development, uterine implantation, and healthy pregnancy depend on the quality of oocytes, and morphological evaluation is one of the options used to predict quality levels. In this review, the morphological criteria being utilized in certain ART centers are comprehensively evaluated with special references to their predictive values and potential contributions to selecting high‐quality oocytes.
Capacitation increases glucose consumption in murine sperm
Authors: Hidalgo David M. , Romarowski Ana , Gervasi María G. , Navarrete Felipe , Balbach Melanie , Salicioni Ana M. , Levin Lonny R. , Buck Jochen , Visconti Pablo E.
Published: September 2020

Mammalian sperm acquire fertilization capacity in the female reproductive tract in a process known as capacitation. During capacitation, sperm change their motility pattern (i.e., hyperactivation) and become competent to undergo the acrosome reaction. We have recently shown that, in the mouse, sperm capacitation is associated with increased uptake of fluorescently labeled deoxyglucose and with extracellular acidification suggesting enhanced glycolysis. Consistently, in the present work we showed that glucose consumption is enhanced in media that support mouse sperm capacitation suggesting upregulation of glucose metabolic pathways. The increase in glucose consumption was modulated by bicarbonate and blocked by protein kinase A and soluble adenylyl cyclase inhibitors. Moreover, permeable cyclic adenosine monophosphate (cAMP) agonists increase glucose consumption in sperm incubated in conditions that do not support capacitation. Also, the increase in glucose consumption was reduced when sperm were incubated in low calcium conditions. Interestingly, this reduction was not overcome with cAMP agonists. Despite these findings, glucose consumption of sperm from Catsper1 knockout mice was similar to the one from wild type suggesting that other sources of calcium are also relevant. Altogether, these results suggest that cAMP and calcium pathways are involved in the regulation of glycolytic energy pathways during murine sperm capacitation.
Score confidence intervals and sample sizes for stratified comparisons of binomial proportions
Authors: Tang Yongqiang
Published: September 2020

In a series of articles, Gart and Nam construct the efficient score tests and confidence intervals with or without skewness correction for stratified comparisons of binomial proportions on the risk difference, relative risk, and odds ratio effect metrics. However, the stratified score methods and their properties are not well understood. We rederive the efficient score tests, which reveals their theoretical relationship with the contrast‐based score tests, and provides a basis for adapting the method by using other weighting schemes. The inverse variance weight is optimal for a common treatment effect in large samples. We explore the behavior of the score approach in the presence of extreme outcomes when either no or all subjects in some strata are responders, and provide guidance on the choice of weights in the analysis of rare events. The score method is recommended for studies with a small number of moderate or large sized strata. A general framework is proposed to calculate the asymptotic power and sample size for the score test in superiority, noninferiority and equivalence clinical trials, or case‐control studies. We also describe a nearly exact procedure that underestimates the exact power, but the degree of underestimation can be controlled to a negligible level. The proposed methods are illustrated by numerical examples.
Nonfullerene All‐Small‐Molecule Organic Solar Cells: Prospect and Limitation
Authors: Ye Weiyu , Yang Yue , Zhang Zhenzhen , Zhu Yufan , Ye Liu , Miao Chunyang , Lin Yuze , Zhang Shiming
Published: September 2020

Organic solar cells (OSCs) have great potential to completely change the development trend of entire industries and become the next generation of commercial solar cells. Compared with polymer solar cells, the nonfullerene all‐small‐molecule organic solar cells (NF‐ASM OSCs) system has the advantages of easy purification, no batch effect, etc. Moreover, their power conversion efficiency (PCE) exceeds the commercialization threshold of 10%. Recently, the diversity of small‐molecule materials and the steady increase in PCE values suggest a bright future for NF‐ASM OSCs. Herein, small‐molecule donor and acceptor materials that have been developed in recent years to produce higher device efficiency are introduced.
Meaningful Making in the Contemporary Creative Economy
Authors: Luckman Susan , Andrew Jane
Published: September 2020

This chapter introduces the people and their stories that inform this book, including the reasons behind their choice to pursue craft or design, despite the frequently precarious incomes to be made. One of the strongest findings to emerge in this study is the centrality of early exposures to making to later comfort with and motivation to give craft and design ‘a go’. How the makers connect their current identities to formative earlier familial and educational experiences is explored. These findings are then situated analytically within critical scholarship on the values of crafts-based practice today as they sit alongside the rise of neoliberal individualised work practices, including the normalisation of self-employment and microenterprise, with all the associated personal financial risk-taking this entails.
Research Ethics Step by Step
Authors: Bos Jaap
Published: September 2020

After Reading This Chapter, You Will:

Have a general knowledge of Institutional Review Board (IRB) procedures

Have the capacity to anticipate the basic ethical pitfalls in research designs

Know how to counter common ethical objections

Be able to design an informed consent form
Ageing Societies and Technological Innovation
Authors: Jarke Juliane
Published: September 2020

Demographic ageing has been declared one of the main challenges for countries in the Global North by politicians, journalists, industry and academia alike. Many frame ageing as a problem that needs a technological fix and most digital technologies designed for older adults, reproduce images about old age defined by ill health, deficits and limitations. Digital public services are no different. However, scholars in critical and social gerontology argue that most of the alarmist rhetoric around demographic ageing and projected social implications are based on flawed assumptions about older people (e.g. their ability to contribute to their communities) and the ageing process (e.g. as solely described in terms of decline and long-term care needs). This chapter reviews dominant concepts about ageing societies, older adults and technological innovation. It argues, that engaging older adults in design processes, allows for alternative measures and attributes of “success” in later life and that participatory approaches can reconfigure how and which imaginaries and social practices are being scripted into technologies.
Funktionelle Ergebnisse nach transmandibulärer Resektion und primärer Radiochemotherapie bei fortgeschrittenen Kopf-Hals-Plattenepithelkarzinomen
Authors: Knopf A. , Mansour N. , Hofauer B. , Johnson F. , Bier H. , Wakonig F. , Teutsch S.
Published: September 2020

Ziel der Arbeit

In dieser Studie wurden die funktionellen Ergebnisse nach transmandibulärer Resektion und Rekonstruktion mittels mikrovaskulär anastomosiertem Radialistransplantat (TMR+Tx) gegenüber einer primären Radiochemotherapie (pRCT) bei fortgeschrittenen orophayngealen Plattenepithelkarzinomen (OPSCC) verglichen.

Methoden

Es erfolgte ein Vergleich zwischen 50 OPSCC-Patienten mit TMR+Tx und 50 OPSCC-Patienten mit pRCT. Die Wasserschluckzeit war als primärer Endpunkt definiert. Der Saxon-Test, die maxillomandibuläre Distanz, der Mallampati-Score, der Quotient aus Körpergröße zu Gewicht, eine nasale Penetration, das Vorhandensein einer Ernährungssonde/Tracheostomie sowie 4 validierte Fragebögen (Visuelle Analogskala zur Mundtrockenheit, Sicca VAS; MD Anderson Dysphagia Inventory, MDADI; Voice Handicap Index, VHI; European Organization for Research and Treatment of Cancer Quality of Life Questionnaire – Head and Neck Cancer – 35 Items, QLQ-H&N35) dienten als sonstige Endpunkte zur Beurteilung der Funktion und Lebensqualität.

Ergebnisse

Die Gesamtkohorte an operierten Patienten zeigte eine erhöhte Rate an nasaler Penetration (p < 0,0001), was mit einer verlängerten Wasserschluckzeit verbunden war (p < 0,05). Durch eine modifizierte Rekonstruktion des Weichgaumens wurde die nasale Penetration in der chirurgisch therapierten Gruppe im Vergleich zur klassischen Rekonstruktion signifikant reduziert (p = 0,0001). Patienten mit pRCT litten signifikant stärker an einer Xerostomie (Saxon-Test) als Patienten nach TMR+Tx und Adjuvanz (p = 0,001). In den Fragebögen zur Funktionalität und Lebensqualität zeigte sich kein Unterschied zwischen den Gruppen.

Schussfolgerung

Die TMR+Tx mit modifizierter Rekonstruktion und adjuvante Therapie zeigte gegenüber der pRCT vergleichbare funktionelle Ergebnisse.
Interleukin 15 and Eotaxin correlate with the outcome of breast cancer patients vice versa independent of CTC status
Authors: Vilsmaier Theresa , Heidegger Helene Hildegard , Schröder Lennard , Trapp Elisabeth , zehni Alaleh Zati , Rack Brigitte , Janni Wolfgang , Mahner Sven , Weissenbacher Tobias , Jeschke Udo , Mumm Jan-Niclas ,   SUCCESS Study Group, Vilsmaier Theresa , Heidegger Helene Hildegard , Schröder Lennard
Published: September 2020

Background

Circulating tumor cells (CTC) in the peripheral blood in women with breast cancer has been found to be an indicator of prognosis before the start of systemic treatment. The aim of this study is the assessment of specific cytokine profiles as markers for CTC involvement that could act as independent prognostic markers in terms of survival outcome for breast cancer patients.

Methods

Patients selected for this study were defined as women with breast cancer of the SUCCESS study. A total of 200 patients’ sera were included in this study, 100 patients being positive for circulating tumor cells (CTC) and 100 patients being CTC negative. The matching criteria were histo-pathological grading, lymph node metastasis, hormone receptor status, TNM classification, and patient survival. Commercial ELISA with a multi cytokine/chemokine array was used to screen the sera for Interleukin 15 (IL-15) and eotaxin.

Results

Statistically significant concentrations were exposed for IL-15 levels regardless of the CTC-Status, lymph node involvement, or hormone receptor status. Significantly enhanced serum IL-15 concentrations were observed in those patients with worse overall survival (OS) and disease-free survival (DFS). Elevated serum concentrations of IL-15 significantly correlate with patients diagnosed with Grade 3 tumor and worse OS. In contrast, patients with a Grade 3 tumor with a favourable OS and DFS demonstrated significantly decreased IL-15 values. The CTC negative patient subgroup with a favourable OS and DFS, showed statistically significant elevated eotaxin values.

Conclusion

These findings suggest a potential functional interaction of increased IL-15 concentrations in the peripheral blood of patients with a worse OS and DFS, regardless of prognostic factors at primary diagnosis. The increased levels of the chemokine eotaxin in CTC negative patients and a favourable OS and DFS, on the other hand, suggest that the overexpression inhibits CTCs entering the peripheral blood, thus emphasizing a significant inhibition of circulation specific metastasis. To sum up, IL-15 could be used as an independent prognostic marker in terms of survival outcome for breast cancer patients and used as an early indicator to highlight high-risk patients and consequently the adjustment of cancer therapy strategies.
The model structure of the copper-dependent ammonia monooxygenase
Authors: Musiani Francesco , Broll Valquiria , Evangelisti Elisa , Ciurli Stefano
Published: September 2020

Ammonia monooxygenase is a copper-dependent membrane-bound enzyme that catalyzes the first step of nitrification in ammonia-oxidizing bacteria to convert ammonia to hydroxylamine, through the reductive insertion of a dioxygen-derived O atom in an N–H bond. This reaction is analogous to that carried out by particulate methane monooxygenase, which catalyzes the conversion of methane to methanol. The enzymatic activity of ammonia monooxygenase must be modulated to reduce the release of nitrogen-based soil nutrients for crop production into the atmosphere or underground waters, a phenomenon known to significantly decrease the efficiency of primary production as well as increase air and water pollution. The structure of ammonia monooxygenase is not available, rendering the rational design of enzyme inhibitors impossible. This study describes a successful attempt to build a structural model of ammonia monooxygenase, and its accessory proteins AmoD and AmoE, fromNitrosomonas europaea, taking advantage of the high sequence similarity with particulate methane monooxygenase and the homologous PmoD protein, for which crystal structures are instead available. The results obtained not only provide the structural details of the proteins ternary and quaternary structures, but also suggest a location for the copper-containing active site for both ammonia and methane monooxygenases, as well as support a proposed structure of a CuA-analogue dinuclear copper site in AmoD and PmoD.

Graphic abstract
Non-programmed gait generation of quadruped robot using pulse-type hardware neuron models
Authors: Takei Yuki , Morishita Katsuyuki , Tazawa Riku , Katsuya Koichi , Saito Ken
Published: September 2020

In this paper, the authors will propose the active gait generation of a quadruped robot. The theory that quadruped animals unconsciously generate gaits by some system based on neural networks in the spinal cord is widely accepted. However, how biological neurons or neural networks can generate gaits is not clear. To clarify the gait generation method, one of the solutions is using the neuron model similar to the biological neuron. We developed the quadruped robot system using self-inhibited pulse-type hardware neuron models (P-HNMs), which can output the electrical activity similar to those of biological neurons. The P-HNMs consist of the cell body model and the inhibitory synaptic model. The cell body model periodically outputs pulsed voltages; the inhibitory synaptic model inhibits the pulsed voltages. The pulse period can change by varying the synaptic weight control voltage applied to the P-HNMs. We varied the synaptic weight control voltage according to the pressure on the robot’s toes. Also, we changed the angle of the robot’s joints by a constant angle each time the P-HNMs output a pulse. As a result of the walking experiment, we confirmed that the robot generates walk gait and trot gait according to the moving speed. Also, we clarified the process by which the robot actively generates gaits from the upright state. These results show that animals may not use many biological neurons to generate gaits. Furthermore, the results suggest the possibility of realizing simple and bio-inspired robot control.
Preparation of cellulose-rich membranes from wood: effect of wood pretreatment process on membrane performance
Authors: Lopatina Anastasiia , Anugwom Ikenna , Esmaeili Mohammadamin , Puro Liisa , Virtanen Tiina , Mänttäri Mika , Kallioinen Mari
Published: September 2020

In this study cellulose-rich membranes were fabricated from untreated and treated hardwood biomass solutions in 1-ethyl-3-methylimidazolium acetate ([Emim][OAc])—dimetylsulfoxide (DMSO) system via wet phase separation. Wood treatment methods aimed to get purified cellulose fraction of wood. Treatment sequence was as followed: deep eutectic solvent pretreatment, sodium chlorite bleaching, and alkaline treatment. Resulted biomass after each treatment step was characterized by chemical composition and crystalline fraction content. Flat-sheet membranes were produced from biomass samples after each treatment step. Characterization of membranes included measurements of pure water permeability and (poly)ethyleneglycol 35 kDa retention, Fourier-transform infrared and Raman spectroscopy, X-ray diffraction measurements and thermogravimetric analysis. The study revealed that it was possible to fabricate membrane from untreated wood as well as from wood biomass after each of treatment steps. The resulted membranes differed in chemical composition and filtration performance. Membrane prepared directly from untreated wood had the highest permeability, the lowest retention; and the most complex chemical composition among others. As treatment steps removed lignin and hemicelluloses from the wood biomass, the corresponding membranes became chemically more homogeneous and showed increased retention and decreased permeability values.
The Hardest Paradox for Closure
Authors: Smith Martin
Published: September 2020

According to the principle of Conjunction Closure, if one has justification for believing each of a set of propositions, one has justification for believing their conjunction. The lottery and preface paradoxes can both be seen as posing challenges for Closure, but leave open familiar strategies for preserving the principle. While this is all relatively well-trodden ground, a new Closure-challenging paradox has recently emerged, in two somewhat different forms, due to Backes (Synthese 196(9):3773–3787, 2019a) and Praolini (Australas J Philos 97(4):715–726, 2019). This paradox synthesises elements of the lottery and the preface and is designed to close off the familiar Closure-preserving strategies. By appealing to a normic theory of justification, I will defend Closure in the face of this new paradox. Along the way I will draw more general conclusions about justification, normalcy and defeat, which bear upon what Backes (Philos Stud 176(11):2877–2895, 2019b) has dubbed the ‘easy defeat’ problem for the normic theory.
Si3N4 nanofelts/paraffin composites as novel thermal energy storage architecture
Authors: Valentini Francesco , Dorigato Andrea , Pegoretti Alessandro , Tomasi Michele , Sorarù Gian D. , Biesuz Mattia
Published: September 2020

The environmental problems associated with global warming are urging the development of novel systems to manage and reduce the energy consumption. An attractive route to improve the energy efficiency of civil buildings is to store the thermal energy thanks, during heating, to the phase transition of a phase-change material (as paraffin) from the solid to the liquid state and vice versa. The stored energy can be then released under cooling. Herein, we developed a novel material (nanofelt) constituted by Si3N4nanobelts able to absorb huge amounts of liquid paraffin in the molten state and to act as an efficient shape stabilizer. The nanofelt manufacturing technology is very simple and easy to be scaled-up. The effect of the Si3N4nanofelts density and microstructure on the paraffin sorption and leakage and on the thermal properties of the resulting composite structures is investigated. It is shown that the produced Si3N4/paraffin composites are able to retain enormous fractions of paraffin (up to 70 wt%) after 44 day of desorption test on absorbent paper towel. The thermal energy storage efficiency measured through calorimetric tests is as high as 77.4% in heating and 80.1% in cooling.
Stable honeycomb structures and temperature based trajectory optimization for wire-arc additive manufacturing
Authors: Bähr Martin , Buhl Johannes , Radow Georg , Schmidt Johannes , Bambach Markus , Breuß Michael , Fügenschuh Armin
Published: September 2020

We consider two mathematical problems that are connected and occur in the layer-wise production process of a workpiece using wire-arc additive manufacturing. As the first task, we consider the automatic construction of a honeycomb structure, given the boundary of a shape of interest. In doing this, we employ Lloyd’s algorithm in two different realizations. For computing the incorporated Voronoi tesselation we consider the use of a Delaunay triangulation or alternatively, the eikonal equation. We compare and modify these approaches with the aim of combining their respective advantages. Then in the second task, to find an optimal tool path guaranteeing minimal production time and high quality of the workpiece, a mixed-integer linear programming problem is derived. The model takes thermal conduction and radiation during the process into account and aims to minimize temperature gradients inside the material. Its solvability for standard mixed-integer solvers is demonstrated on several test-instances. The results are compared with manufactured workpieces.
Baseline chest X-ray in coronavirus disease 19 (COVID-19) patients: association with clinical and laboratory data
Authors: Gatti Marco , Calandri Marco , Barba Matteo , Biondo Andrea , Geninatti Carlotta , Gentile Stephanie , Greco Marta , Morrone Vittorio , Piatti Clara , Santonocito Ambra , Varello Sara , Bergamasco Laura , Cavallo Rossana , Di Stefano Rosario , Riccardini Franco , Boccuzzi Adriana , Limerutti Giorgio , Veltri Andrea , Fonio Paolo , Faletti Riccardo
Published: September 2020

Purpose

To assess the reliability of CXR and to describe CXR findings and clinical and laboratory characteristics associated with positive and negative CXR.

Methods

Retrospective two-center study on consecutive patients admitted to the emergency department of two north-western Italian hospitals in March 2020 with clinical suspicion of COVID-19 confirmed by RT-PCR and who underwent CXR within 24 h of the swab execution. 260 patients (61% male, 62.8 ± 15.8 year) were enrolled. CXRs were rated as positive (CXR+) or negative (CXR−), and features reported included presence and distribution of airspace opacities, pleural effusion and reduction in lung volumes. Clinical and laboratory data were collected. Statistical analysis was performed with nonparametric tests, binary logistic regression (BLR) and ROC curve analysis.

Results

Sensitivity of CXR was 61.1% (95%CI 55–67%) with a typical presence of bilateral (62.3%) airspace opacification, more often with a lower zone (88.7%) and peripheral (43.4%) distribution. At univariate analysis, several factors were found to differ significantly between CXR+ and CXR−. The BLR confirmed as significant predictors only lactate dehydrogenase (LDH), C-reactive protein (CRP) and interval between the onset of symptoms and the execution of CXR. The ROC curve procedure determined that CRX+ was associated with LDH > 500 UI/L (AUC = 0.878), CRP > 30 mg/L (AUC = 0.830) and interval between the onset of symptoms and the execution of CXR > 4 days (AUC = 0.75). The presence of two out of three of the above-mentioned predictors resulted in CXR+ in 92.5% of cases, whereas their absence in 7.4%.

Conclusion

CXR has a low sensitivity. LDH, CRP and interval between the onset of symptoms and the execution of CXR are major predictors for a positive CXR.
Modulation of visual processing of food by transcutaneous vagus nerve stimulation (tVNS)
Authors: Alicart Helena , Heldmann Marcus , Göttlich Martin , Obst Martina A. , Tittgemeyer Marc , Münte Thomas F.
Published: September 2020

Present project is concerned with the possibility to modulate the neural regulation of food intake by non-invasive stimulation of the vagus nerve. This nerve carries viscero-afferent information from the gut and other internal organs and therefore serves an important role in ingestive behavior. The electrical stimulation of the vagus nerve (VNS) is a qualified procedure in the treatment of drug-resistant epilepsy and depression. Since weight loss is a known common side effect of VNS treatment in patients with implanted devices, VNS is evaluated as a treatment of obesity. To investigate potential VNS-related changes in the cognitive processing of food-related items, 21 healthy participants were recorded in a 3-Tesla scanner in two counterbalanced sessions. Participants were presented with 72 food pictures and asked to rate how much they liked that food. Before entering the scanner subjects received a 1-h sham or verum stimulation, which was implemented transcutanously with a Cerbomed NEMOS® device. We found significant activations in core areas of the vagal afferent pathway, including left brainstem, thalamus, temporal pole, amygdala, insula, hippocampus, and supplementary motor area for the interaction between ratings (high vs low) and session (verum vs sham stimulation). Significant activations were also found for the main effect of verum compared to sham stimulation in the left inferior and superior parietal cortex. These results demonstrate an effect of tVNS on food image processing even with a preceding short stimulation period. This is a necessary prerequisite for a therapeutic application of tVNS which has to be evaluated in longer-term studies.
André Martineau: Some Memories
Authors: Kiselman Christer Oscar
Published: September 2020

This essay presents memories of André Martineau (1930–1972).
Missed Lisfranc injuries—surgical vs conservative treatment
Authors: Singh Amit , Lokikere Naveen , Saraogi Aakash , Unnikrishnan P. N. , Davenport James
Published: September 2020

Introduction

Lisfranc injuries form a distinct group of rare but severe injury. Literature suggests a low incidence, but failure to diagnose these injuries early and its subsequent delay in management will affect the patient’s mobility and quality of life significantly. The preferred mode of management is said to be surgical. Conversely, the method of intervention for patients not suitable for surgery is less clear.

Aim

This study aims to evaluate the effect of delayed diagnosis and the treatment provided on the overall functional outcome for the patients with missed Lisfranc injury.

Methodology

The study was conducted at a specialist centre in the North-West of UK between January 2011 and November 2016. All patients with acute Lisfranc injuries were included in this study. Patient data was collected through electronic notes and analysed to ascertain missed diagnosis. It was also used to evaluate functional and radiological outcome.

Results

In our series, 58.8% of Lisfranc injuries were missed on their initial presentation. We report better results for the surgical group when compared with the non-operated group, in spite of the delay in diagnosis.

Conclusion

We believe that definitive treatment in the form of surgical fixation and anatomical reduction has more influence on the functional outcome than the timing of the surgical fixation in case of subtle Lisfranc injuries.
Evaluation of exposure dose in fetal computed tomography using organ-effective modulation
Authors: Kobayashi Masanao , Haba Tomonobu , Suzuki Sayaka , Nishihara Yusei , Asada Yasuki , Minami Kazuyuki
Published: September 2020

Organ-effective modulation (OEM) is a computed tomography scanning technique that reduces the exposure dose to organs at risk. Ultrasonography is commonly used for prenatal imaging, but its reliability is reported to be limited. Radiography and computed tomography (CT) are reliable but pose risk of radiation exposure to the pregnant woman and her fetus. Although there are many reports on the exposure dose associated with fetal CT scans, no reports exist on OEM use in fetal CT scans. We measured the basic characteristics of organ-effective modulation (X-ray output modulation angle, maximum X-ray output modulation rate, total X-ray output modulation rate, and noise modulation) and used them in a Monte Carlo simulation to evaluate the effect of this technique on fetal CT scans in terms of image quality and exposure dose to the pregnant woman and fetus. Using ImPACT MC software, Monte Carlo simulations of OEMON and OEMOFF were run on 8 cases involving fetal CT scans. We confirmed that the organ-effective modulation X-ray output modulation angle was 160°; the X-ray output modulation rate increased with increasing tube current; and no modulation occurred at tube currents of 80 mA or below. Our findings suggest that OEM has only a minimal effect in reducing organ exposure in pregnant women; therefore, it should be used on the anterior side (OEMON,front) to reduce the exposure dose to the fetus.
Politics and the Federal Court of Malaysia, 1960–2018: An Empirical Investigation
Authors: Dressel Björn , Inoue Tomoo
Published: September 2020

Since its inception in 1957, Malaysia’s Federal Court (FC) has often been embroiled in high-profile decisions that have dramatically shaped the rule of law and constitutional practice in Malaysia. Recent political change has renewed hope that the FC can reassert its early role as an independent and impartial arbiter of political conflict. This paper investigates determinants of the FC’s behaviour since 1960. It draws on a unique data set of 102 major political cases and socio-biographic profiles of the 73 judges who voted in these cases. After describing patterns of court decisions across time and judges, we test specifically for the impact on their decisions of the 1988 judicial crisis, length of time on the bench, the terms of successive prime ministers, and judges’ personal attributes, such as religion and ethnicity. Ethnicity, appointment after 1988, and the appointing prime minister proved to be closely associated with the direction of voting. We then position the results in the context of Malaysia’s evolving constitutional democracy and discuss their implications for students of comparative judicial politics.
The exchange between citizens and elected officials: a social psychological framework for citizen climate activists
Authors: SHERMAN DAVID K. , SHTEYN MICHELLE F. , HAN HAHRIE , VAN BOVEN LEAF
Published: September 2020

Citizen activists play a role in translating public concern about the climate crisis to policymakers and elevating it on the political agenda. We consider the dynamic between citizen activists and the decision-makers they seek to influence and we review psychological research relevant to advocating for climate legislation. We conducted a study with citizen activists who lobby the US Congress for a carbon pricing policy to address climate change. The study assessed how activists think about four social psychological approaches: affirmation, social norms, legacy and immediacy. The findings provide a window into activists’ intuitions about which strategies to use, whom to use them with and their perceived effectiveness. A strategy of establishing shared values and common ground (affirmation) was used most frequently overall. A strategy emphasizing the long-term costs and benefits of addressing climate change (legacy) was employed less frequently than affirmation and seen as less effective by activists but it was the only strategy that was associated with perceived increases in Congressional Representatives’ support of the policy. Citizen activists and their interactions with elected officials provide an opportunity for social-behavioral scientists to understand and potentially overcome barriers to enacting climate policy.
On solvable groups with one vanishing class size
Authors: Bianchi M. , Pacifici E. , Camina R. D. , Lewis Mark L.
Published: September 2020

Let G be a finite group, and let cs(G) be the set of conjugacy class sizes of G. Recalling that an element g of G is called a vanishing element if there exists an irreducible character of G taking the value 0 on g, we consider one particular subset of cs(G), namely, the set vcs(G) whose elements are the conjugacy class sizes of the vanishing elements of G. Motivated by the results inBianchi et al. (2020, J. Group Theory, 23, 79–83), we describe the class of the finite groups G such that vcs(G) consists of a single element under the assumption that G is supersolvable or G has a normal Sylow 2-subgroup (in particular, groups of odd order are covered). As a particular case, we also get a characterization of finite groups having a single vanishing conjugacy class size which is either a prime power or square-free.
Seniority-Based Nominations and Political Careers
Authors: CIRONE ALEXANDRA , COX GARY W. , FIVA JON H.
Published: September 2020

This paper investigates party use of seniority systems to allocate nominations for elected and appointed offices. Such systems, which can regulate party members’ access to offices at multiple levels of their careers, are defined by two main rules or norms: an incumbent re-nomination norm and a seniority progression norm. Using comprehensive electoral and candidate data from Norwegian local and national elections from 1945 to 2019, we find systematic patterns consistent with these two norms. Our work illuminates an institutional aspect of candidate selection that the current literature has ignored while noting some of the important consequences of seniority-based nominations for party cohesion and stability.
Attributing Policy Influence under Coalition Governance
Authors: FORTUNATO DAVID , LIN NICK C. N. , STEVENSON RANDOLPH T. , TROMBORG MATHIAS WESSEL
Published: September 2020

Coalition governance divides policy-making influence across multiple parties, making it challenging for voters to accurately attribute responsibility for outcomes. We argue that many voters overcome this challenge by inferring parties’ policy-making influence using a simple heuristic model that integrates a number of readily available and cheaply obtained informational cues about parties (e.g., their roles in government and legislative seat shares)—while ignoring other cues that, while predictive of real-world influence, are not suitable for heuristic inference (e.g., median party status and bargaining power). Using original data from seven surveys in five countries, we show that voters’ attributions of parties’ policy-making influence are consistent with our proposed inferential strategy. Our findings suggest that while voters certainly have blind spots that cause them to misattribute policy responsibility in some situations, their attributions are generally sensible and consistent with the academic research on multiparty policy making.
An integrative approach assesses the intraspecific variations ofProcamallanus(Spirocamallanus)inopinatus, a common parasite in Neotropical freshwater fishes, and the phylogenetic patterns of Camallanidae
Authors: Ailán-Choke Lorena G. , Tavares Luiz E.R. , Luque José L. , Pereira Felipe B.
Published: September 2020

Integrative taxonomy was used to evaluate two component populations ofProcamallanus(Spirocamallanus)inopinatusin Brazil and the phylogeny Camallanidae. Parasite populations were collected in the characiformAnostomoides passionisfrom River Xingu (Amazon basin) andMegaleporinus elongatusfrom River Miranda (Paraguay basin). Morphology was analysed using light and scanning electron microscopy (SEM). Genetic characterization was based on partial sequences of the 18S and 28S rDNA, and COI mtDNA. Phylogenies were based on 18S and COI due to data availability. Generalized Mixed Yule Coalescent (GMYC), Poisson Tree Process (PTP) and *BEAST were used for species delimitation and validation. SEM revealed for the first time the presence of minute denticles and pore-like structures surrounding the oral opening, phasmids in females and confirmed other important morphological aspects. Statistical comparison between the two-component populations indicated morphometric variations, especially among males. The different component population ofP. (S.)inopinatusshowed variable morphometry, but uniform morphology and were validated as conspecific by the GMYC, PTP and *BEAST. Some camallanid sequences in GenBank have incorrect taxonomic labelling. Host, environment and geographic aspects seem to be related to some lineages within Camallanidae; however, their real phylogenetic meanings are still unclear.
THE MIDDLE HELLADIC POTTERY OF LEFKANDI PHASES IV–VI: AN INTRODUCTION
Authors: Dickinson Oliver
Published: September 2020

This paper presents a more detailed account of the pottery of Phases IV–VI in the Middle Helladic (MH) sequence at Lefkandi: Xeropolis than is available in the preliminary report. It is based essentially on an unfinished draft compiled by Roger Howell (the Howell manuscript). After an introduction on the background, there is discussion of the Howell manuscript, and then an analysis of the stratigraphy of Trench CC, the basis for the phasing of the pre-Mycenaean phases of Lefkandi; brief comments are also provided on those trial trenches that produced relevant material. The pottery of the three phases is then set out in detail, with attention to the relative popularity of wares and the shapes within those wares, and to possible imports, and they are argued to be classifiable as later ‘MH I’ (Phase IV), advanced ‘MH II’ (Phase V), and the early Mycenaean period, quite possibly starting in ‘MH III’ but continuing well into Late Helladic II (Phase VI). A summary sets out some distinctive characteristics of the Lefkandi sequence, as deducible from this material, and some general conclusions.
Spreading of SARS-CoV-2 in West Africa and assessment of risk factors
Authors: Tinto B. , Salinas S. , Dicko A. , Kagone T. S. , Traore I. , de Rekeneire N. , Bicaba B. W. , Hien H. , Meda N. , van de Perre P. , Kania D. , Simonin Y.
Published: September 2020

Although the African continent is, for the moment, less impacted than the rest of the world, it still faces the risk of a spread of COVID-19. In this study, we have conducted a systematic review of the information available in the literature in order to provide an overview of the epidemiological and clinical features of COVID-19 pandemic in West Africa and of the impact of risk factors such as comorbidities, climatic conditions and demography on the pandemic. Burkina Faso is used as a case study to better describe the situation in West Africa. The epidemiological situation of COVID-19 in West Africa is marked by a continuous increase in the numbers of confirmed cases. This geographic area had on 29 July 2020, 131 049 confirmed cases by polymerase chain reaction, 88 305 recoveries and 2102 deaths. Several factors may influence the SARS-CoV-2 circulation in Africa: (i) comorbidities: diabetes mellitus and high blood pressure could lead to an increase in the number of severe cases of SARS-CoV-2; (ii) climatic factors: the high temperatures could be a factor contributing to slow the spread of the virus and (iii) demography: the West Africa population is very young and this could be a factor limiting the occurrence of severe forms of SARS-CoV-2 infection. Although the spread of the SARS-CoV-2 epidemic in West Africa is relatively slow compared to European countries, vigilance must remain. Difficulties in access to diagnostic tests, lack of hospital equipment, but also the large number of people working in the informal sector (such as trading, businesses, transport and restoration) makes it difficult to apply preventive measures, namely physical distancing and containment.