Unbiased screen for interactors of leucine-rich repeat kinase 2 supports a common pathway for sporadic and familial Parkinson disease
Authors: Beilina Alexandria , Rudenko Iakov N. , Kaganovich Alice , Civiero Laura , Chau Hien , Kalia Suneil K. , Kalia Lorraine V. , Lobbestael Evy , Chia Ruth , Ndukwe Kelechi , Ding Jinhui , Nalls Mike A. ,   International Parkinson’s Disease Genomics Consortium,   North American Brain Expression Consortium, Olszewski Maciej , Hauser David N. , Kumaran Ravindran , Lozano Andres M. , Baekelandt Veerle , Greene Lois E. , Taymans Jean-Marc , Greggio Elisa , Cookson Mark R. , Nalls Mike A. , Plagnol Vincent , Martinez Maria , Hernandez Dena G , Sharma Manu , Sheerin Una-Marie , Saad Mohamad , Simón-Sánchez Javier , Schulte Claudia , Lesage Suzanne , Sveinbjörnsdóttir Sigurlaug , Arepalli Sampath , Barker Roger , Ben-Shlomo Yoav , Berendse Henk W , Berg Daniela , Bhatia Kailash , de Bie Rob M A , Biffi Alessandro , Bloem Bas , Bochdanovits Zoltan , Bonin Michael , Bras Jose M , Brockmann Kathrin , Brooks Janet , Burn David J , Charlesworth Gavin , Chen Honglei , Chong Sean , Clarke Carl E , Cookson Mark R , Cooper J Mark , Corvol Jean Christophe , Counsell Carl , Damier Philippe , Dartigues Jean-François , Deloukas Panos , Deuschl Günther , Dexter David T , van Dijk Karin D , Dillman Allissa , Durif Frank , Dürr Alexandra , Edkins Sarah , Evans Jonathan R , Foltynie Thomas , Gao Jianjun , Gardner Michelle , Gibbs J Raphael , Goate Alison , Gray Emma , Guerreiro Rita , Gústafsson Ómar , Harris Clare , van Hilten Jacobus J , Hofman Albert , Hollenbeck Albert , Holton Janice , Hu Michele , Huang Xuemei , Huber Heiko , Hudson Gavin , Hunt Sarah E , Huttenlocher Johanna , Illig Thomas , München Helmholtz Zentrum , Jónsson Pálmi V , Lambert Jean-Charles , Langford Cordelia , Lees Andrew , Lichtner Peter , München Helmholtz Zentrum , Limousin Patricia , Lopez Grisel , Lorenz Delia , McNeill Alisdair , Moorby Catriona , Moore Matthew , Morris Huw R , Morrison Karen E , Mudanohwo Ese , O’Sullivan Sean S , Pearson Justin , Perlmutter Joel S , Pétursson Hjörvar , Pollak Pierre , Post Bart , Potter Simon , Ravina Bernard , Revesz Tamas , Riess Olaf , Rivadeneira Fernando , Rizzu Patrizia , Ryten Mina , Sawcer Stephen , Schapira Anthony , Scheffer Hans , Shaw Karen , Shoulson Ira , Sidransky Ellen , Smith Colin , Spencer Chris C A , Stefánsson Hreinn , Steinberg Stacy , Stockton Joanna D , Strange Amy , Talbot Kevin , Tanner Carlie M , Tashakkori-Ghanbaria Avazeh , Tison François , Trabzuni Daniah , Traynor Bryan J , Uitterlinden André G , Velseboer Daan , Vidailhet Marie , Walker Robert , van de Warrenburg Bart , Wickremaratchi Mirdhu , Williams Nigel , Williams-Gray Caroline H , Winder-Rhodes Sophie , Stefánsson Kári , Hardy John , Heutink Peter , Brice Alexis , Gasser Thomas , Singleton Andrew B , Wood Nicholas W , Chinnery Patrick F , Arepalli Sampath , Cookson Mark R , Dillman Allissa , Ferrucci Luigi , Gibbs J Raphael , Hernandez Dena G , Johnson Robert , Longo Dan L , Majounie Elisa , Nalls Michael A , O’Brien Richard , Singleton Andrew B , Traynor Bryan J , Troncoso Juan , van der Brug Marcel , Zielke H Ronald , Zonderman Alan B 
Published: February 2014

Significance

Understanding loci nominated by genome-wide association studies (GWASs) is challenging. Here, we show, using the specific example of Parkinson disease, that identification of protein–protein interactions can help determine the most likely candidate for several GWAS loci. This result illustrates a significant general principle that will likely apply across multiple diseases.