bluuebunny/crossref_metadata_2025 huggingface dataset:
MADRASAH DAN EKSISTENSINYA DALAM PEMBAHARUAN PENDIDIKAN ISLAM MASA PENJAJAHAN BELANDA DAN JEPANG
Authors: Agustina Anna , Alawi Muhammad Agus , Iskarim Mochamad
Published: August 2024

Madrasah as a form of Islamic educational institution play an important role in fostering the spirit of nationalism and resistance to colonialism in Indonesia.. The establishment of madrasah in Indonesia represents a reform of traditional Islamic education systems such as pesantren, surau, and religious studies that were prevalent across the archipelago. This research aims to explore the reforms undertaken by madrasah in Islamic education during the Dutch and Japanese colonial periods in Indonesia. The study employs a literature review method with a qualitative and socio-historical approach. Through a socio-historical lens, the research seeks to present a factual description and critical analysis of the reforms implemented by madrasah. Based on data gathered from relevant journals and references, it can be concluded that during the 20th century colonial periods of Dutch and Japanese rule, madrasahs innovated Islamic education models by integrating modern educational management systems akin to those used in colonial government schools, while preserving their distinctive religious education characteristic of traditional pesantren model.
PERAN TOKOH IBNU SINA DALAM PEMBARUAN PENDIDIKAN ISLAM
Authors: Munawir  , Laily Maghfiroh  , Thalia Qotherine Nada
Published: August 2024

The purpose of this writing is to find out the role of Ibn Sina both in terms of biography, life and in the world of Islamic education and also to discover the relevance of Ibn Sina's thoughts to education in Indonesia in this modern era. This research method uses descriptive qualitative which uses a type of literature study by collecting data through text literature, both books, journals and articles related to the discussion. The results of the research show that Ibn Sina, as a philosopher, great scientist and education expert, Ibn Sina had ideas about educating children, especially paying attention to moral education in children. Ibn Sina had structured thinking in terms of objectives, curriculum, learning methods, and teachers or educators which are factors in several determinant elements in education. Ibn Sina's thought seeks to form human beings who are human beings, namely people who have potential within themselves in a balanced and comprehensive manner. Ibn Sina's perspective on Islamic education is seen as relevant even though his thoughts regarding education are not from the modern era. Therefore, Ibn Sina's thoughts have become an important reference in advancing the world of education.
ANALISIS IMPLEMENTASI MANAJEMEN DAN STRATEGI WAKAF TUNAI DI LEMBAGA AMIL ZAKAT INFAK SHADAQAH MUHAMMADIYAH
Authors: Chaidir Juariyah , Pakkanna Mukhaer
Published: August 2024

According to data calculated by the Indonesian Waqf Board (BWI), the potential for cash waqf in Indonesia reaches Rp. 120 trillion per year assuming 100 million Indonesian citizens who entrust their money of Rp. 100,000 per month. But in reality, the waqf money collected in 2017 is only Rp. 199 billion and grows to 1.4 trillion in 2022. This is due to waqf money in Indonesia which experiences various obstacles in waqf management and strategy. This study was conducted to determine the implementation of cash waqf management and strategies carried out in dealing with cash waqf problems that have not been maximized as well as the compatibility between the implementation of cash waqf management and strategy at a Zakat Institution and applicable laws. This study uses descriptive qualitative research, namely data collected in the form of words, images, not numbers with survey/field research techniques derived from interviews, observations, and documentation which are then described in the form of narrative text. The results showed that cash waqf management in LazisMu has five functions, namely planning, organizing, implementing, controlling, and supervising waqf, each of which has disadvantages and advantages; The cash waqf strategy carried out in overcoming waqf problems in Indonesia is to collaborate with Sharia Banks and the Ministry of Finance to create a Cash Waqf Linked Sukuk program in 2020; where the implementation of cash waqf management and strategy is by Islamic law and applicable law.
O uso da rede social whatsapp® como ferramenta de educação em saúde
Authors: Fontana Rosane Teresinha , Wachekowski Giovana , Betana Cargnin Marcia , Amabile Guimaraes Carine
Published: August 2024

Buscou-se avaliar a contribuição do uso de uma rede social como ferramenta de educação para a prevenção de agravos e promoção da saúde.  Pesquisa de abordagem qualitativa, norteada pelo método netnográfico que teve como público-alvo, 21 estudantes do oitavo ano de uma escola privada de um município da região noroeste do estado do Rio Grande do Sul. A coleta de dados foi realizada no segundo semestre do ano de 2019 e ocorreu em três momentos distintos, utilizando-se a ferramenta Google Forms e o aplicativo WhatsApp®. O estudo respeitou os preceitos da pesquisa em seres humanos. Dos participantes, 81% nunca havia participado de uma atividade de educação em saúde. A temática de maior interesse dos adolescentes foi Infecções Sexualmente Transmissíveis As atividades de educação em saúde foram bem recebidas pelos estudantes, que foram participativos. A maioria relatou que a atividade foi importante para a sua aprendizagem e mais da metade afirmaram que buscariam o profissional enfermeiro para consultas e orientações, após esta atividade. Pode-se inferir que o WhatsApp pode ser utilizado pelos enfermeiros como uma ferramenta para aproximar adolescentes às atividades de educação em saúde.
O Curso Clássico do Colégio Estadual de Paranavaí na criação do Festival de Música e Poesia de Paranavaí
Authors: Rosa dos Santos Cruz Pessoa Edna Mara , Stentzler Márcia Marlene , De Fátima Henrique de Assis Eloah
Published: August 2024

Resumo: Este estudo é resultado de pesquisa desenvolvida por meio de projeto de Iniciação Científica (PIC-EM) da Universidade Estadual do Paraná (Unespar), campus Paranavaí. O objetivo foi investigar a trajetória histórica do Festival de Música e Poesia de Paranavaí/PR (Femup) criado a partir da iniciativa de alunos do Curso Clássico do Colégio Estadual de Paranavaí, no ano de 1966. Desde então, o Femup é realizado anualmente, promovendo a disseminação de poesias, contos e músicas inéditas. Esta pesquisa oportunizou conhecer a historicidade desse festival e o contexto de sua criação associado à história da educação de Paranavaí. Analisamos publicações no jornal Diário do Noroeste, em blog, além das fontes documentais e registros fotográficos pertencentes ao acervo mantido pelo Colégio Estadual de Paranavaí. Resgatamos memórias, aspectos da história do Femup e da organização dos estudantes em sua formação.
Palavras-chave:  Estudantes, festival, comunidade, música, poesia e contos.
Estágio Supervisionado e o mundo do trabalho: o diálogo entre os concedentes de estágio e o IFMG/Formiga
Authors: Santos Raphael Freitas , Costa Canto Rogerio
Published: August 2024

Em uma instituição de Educação Profissional e Tecnológica (EPT), o setor de estágios é responsável pela gestão dos processos relativos às atividades de estágio e, ainda, ao controle e formalização da divulgação das ofertas de vagas de estágio e de trabalho disponibilizadas pelos meios oficiais da instituição. Acreditamos que, para atrair as concedentes de vagas de estágio e trabalho, seja importante estabelecer um bom canal de interlocução entre a instituição de ensino e as empresas. Isso permite estimular o fortalecimento dos programas de estágio, bem como a inserção de estudantes e egressos em vagas de trabalho. Partindo-se dessa hipótese, questionamos em nossa pesquisa: as atuais formas de divulgação, coleta de informações e acesso ao campus Formiga do IFMG para o oferecimento de vagas de estágio e trabalho atendem aos anseios dos interessados nessa interlocução? A investigação buscou identificar os aspectos relevantes que pudessem colaborar para aprimorar essa relação entre as concedentes de estágio e o IFMG - Campus Formiga. A abordagem desta investigação foi qualitativa e envolveu os servidores da instituição que possuem algum vínculo com os programas de estágio, bem como as concedentes de estágio cujas ofertas de vagas foram direcionadas para os alunos da instituição. Com este estudo visamos beneficiar a interlocução entre os setores econômicos da sociedade e asinstituições de EPT, contribuindo para que mais vagas de estágio e trabalho sejam ofertadas e, com isso, favorecer maior contato direto dos estudantes com o mundo do trabalho, possibilitando que seja colocado em prática o que aprenderam em sala de aula.
Políticas educativas vs praxis pedagógica en la educación primaria portuguesa y francesa: una mirada a los desafíos y la complejidad del ser docente
Authors: Rodrigues Florbela , Ferreira Maria Eduarda
Published: August 2024

Las políticas educativas y los principios que subyacen al aprendizaje dirigido están legitimados por cada país de la comunidad europea. Corresponde a los docentes reflexionar críticamente sobre los supuestos epistémicos que enmarcan los programas curriculares, en un cotidiano de gran complejidad sociocultural y ambiental, y diseñar su práctica educativa. Para impulsar la innovación en el campo del aprendizaje y la formación permanentes, la Unión Europea proporciona a los profesores europeos proyectos de movilidad internacional. Fue en el contexto de una movilidad Erasmus+ a Portugal, de una maestra de primaria en Francia, que se desarrolló este estudio. En una lógica reflexiva, se comparan los sistemas educativos portugués y francés y se analiza el ser docente en un contexto observacional de la enseñanza formal. Se considera que la movilidad internacional constituye un eje lleno de potencial para potenciar un perfil profesional de carácter investigativo de la praxis educativa, ya que se ha conseguido constatar que el contacto observacional con otro espacio educativo y el intercambio de experiencias ha permitido traer una reflexión sobre la adecuación del papel del docente frente a los retos educativos ante la complejidad de esta sociedad multicultural europea.
Produção de um livro infantil como ferramenta de educação em trauma dental para promoção de saúde bucal
Authors: Sousa Samantha , Ibiapina Isla Maria Pereira , Almeida Julio César Franco , Biato Emília Carvalho Leitão , Garcia Fernanda Cristina Pimentel
Published: August 2024

O objetivo deste trabalho foi descrever o desenvolvimento de um livro ilustrado sobre o tema de trauma dental, com foco nas fraturas coronárias em dentes decíduos e permanentes, como estratégia de educação em saúde bucal para crianças. O estudo considerou a faixa etária dos 8 aos 14 anos como um grupo de alto risco para fraturas dentais coronárias, baseando-se na avaliação epidemiológica dos pacientes assistidos pelo projeto de extensão "Trauma dental: prevenção e tratamento" da Universidade de Brasília (UnB), realizado no Hospital Universitário de Brasília (HUB) desde 2011. Os interesses dessa audiência foram levados em conta, e o livro infantil "Uma Janelinha em Dose Dupla: Com Cail e Caíla" foi produzido, apresentando a história de dois irmãos com fraturas dentais e fornecendo informações sobre como lidar com cada situação de forma lúdica e interativa. A obra, que possui 20 páginas ilustradas, está publicada e registrada. Apresenta-se como uma proposta que se põe a trazer nuances artísticas para os espaços de ensinar/aprender em saúde bucal. Trata-se de prover o profissional de saúde de um material literário potente para despertar pensamentos, a ponto de promover a criação autônoma de novas e mais saudáveis práticas de saúde.
Circunferência como lugar geométrico: três propostas pedagógicas diferentes dos acadêmicos da Licenciatura em Matemática
Authors: Philipsen Grützmann Thaís , Silva da Luz Vanessa
Published: August 2024

O presente artigo tem por objetivo apresentar e discutir três propostas didáticas que exploraram a habilidade EF07MA22, presente na Base Nacional Comum Curricular, no componente da Matemática, referente aos Anos Finais do Ensino Fundamental. As ações foram realizadas no contexto da disciplina de Laboratório de Educação Matemática II (LEMA II) do curso de Licenciatura em Matemática da Universidade Federal de Pelotas (UFPel), em Pelotas/RS. As propostas tiveram como objetivo instigar o pensamento geométrico envolvendo a construção de circunferências, utilizando compasso e reconhecendo-a como lugar geométrico, utilizando-a para fazer composições artísticas e resolver problemas que envolvam objetos equidistantes (BRASIL, 2018). Para isso, utilizou-se como abordagem metodológica o educar pela pesquisa, em que os acadêmicos assumem o papel de agentes de seu processo formativo. Essa abordagem apresenta significativo potencial para ampliar o interesse e o entendimento dos estudantes sobre os conceitos geométricos, assim como o desenvolvimento de habilidades socioemocionais e acadêmicas, a longo prazo. Como resultados, pode-se destacar que as três propostas buscaram ultrapassar a visão de um ensino de geometria centrado na aplicação direta de fórmulas, investindo na autonomia reflexiva dos estudantes, bem como na construção da sala de aula como um espaço fértil para o desenvolvimento, a participação e a invenção criativa dos sujeitos envolvidos. A escolha metodológica envolvendo o educar pela pesquisa no ensino de geometria contribuiu para a formação de estudantes mais críticos, autônomos e engajados com o aprendizado.
Projeto de Ensino WebBio: Contribuições de um Website Educacional para a aprendizagem em Biologia
Authors: De Oliveira Renato , Fernando Bovolenta Ovigli Daniel
Published: August 2024

Ambientes virtuais de aprendizagem, blogs e sites hospedam diversos recursos digitais que podem ser potencialmente importantes nos processos educativos. Este estudo teve como objetivo investigar as contribuições de um website específico para a aprendizagem em Biologia. Desenvolvemos o website WebBio como parte de um projeto de ensino com duração de seis meses. Construímos os dados da pesquisa por meio de um questionário em formulário Google. Dez estudantes do 3º ano do Ensino Médio e Técnico Integrado participaram da pesquisa realizada no IFTM - campus Uberaba Parque Tecnológico. A análise do corpus empírico teve uma abordagem qualitativa usando análise de conteúdo. Os resultados indicam que os websites educacionais podem desempenhar um papel significativo no processo ensino-aprendizagem por possibilitar interações e o compartilhamento dinâmico de informações. Vídeos, atividades e podcasts apresentam grande potencial educativo e, quando combinados com um design eficiente, facilidade de acesso, navegação e organização das informações podem manter a motivação, o interesse e o engajamento dos estudantes. Para os participantes da pesquisa, os vídeos vinculados a exercícios foram os recursos do site mais utilizados em seus estudos. O site se revelou uma ferramenta substancial para a revisão de conteúdo. Assim, esta proposta sugere que os websites podem ser instrumentos relevantes de auxílio aos estudos, oferecendo alternativas que possibilitam um aprendizado mais agradável e efetivo.
O Transtorno do Espectro Autista através do filme Farol das Orcas (2016): uma proposta para educadores
Authors: Maçulo Luz Tinoco Lorena , Luiz Batouli Santos André , Santos Leite Lima Alzinete , De Oliveira Santos Pinto Bruna , De Esquivel Dias Brandão Lucas , Diniz Monteiro de Barros Marcelo , Batista Lopes Coelho Júnior João
Published: August 2024

Este guia do educador objetiva auxiliar o trabalho de educadores com dinâmicas relacionadas ao tema TEA, gerando reflexões que podem ser trabalhadas em sala de aula através de um recurso áudio visual. “Farol das Orcas” (2016) é um filme Argentino que retrata o TEA não como uma doença, mas como um espectro de comportamento, mostrando um indivíduo que percebe o mundo de forma diferente. O enredo desta obra foi construído a partir de um livro e a proposta deste artigo é construir, a partir do filme, um guia, com perguntas e reflexões para professores e estudantes das mais variadas licenciaturas.
Os Jogos matemáticos na Educação Básica: um mapeamento de pesquisas
Authors: Oliveira Saulo Macedo de
Published: August 2024

O artigo aqui apresentado orientou-se pelo objetivo de descrever um mapeamento das produções científicas sobre a abordagem dos jogos matemáticos no ensino e aprendizagem da Matemática na Educação Básica. Para a estruturação deste artigo, optou-se por analisar os trabalhos publicados no Catálogo de Teses e Dissertações da Capes, contemplando as pesquisas defendidas entre 2013 a 2023, usando os termos de busca “Jogos matemáticos na Educação Básica” e “Jogos matemáticos no Ensino Básico”. Para a análise das produções, foi utilizado a Análise de Conteúdo, que possibilitou evidenciar sete Categorias de Análise. Enquanto resultados, eles mostram que os alunos, mesmo com as suas idiossincrasias, tiveram maior engajamento nas aulas, em virtude dos jogos utilizados. As pesquisas também evidenciam que a abordagem lúdica no ensino de Matemática favoreceu na aprendizagem dos alunos. Em conclusão, é possível salientar a importância do lúdico para o ensino e aprendizagem da disciplina e também a infinidade de pesquisas concernentes ao escopo desta pesquisa.
Transdisciplinaridade em Espaços não-formais: Um Estudo Exploratório no Planetário de Vitória da Conquista
Authors: Silva Moura Gilson Yuri
Published: August 2024

Este estudo investiga a relevância de espaços alternativos de aprendizagem, como museus e planetários, com ênfase no Planetário de Vitória da Conquista, Bahia. O objetivo é explorar as vantagens de se utilizar planetários no processo de ensino e aprendizagem. Por meio de uma abordagem qualitativa, aplicamos questionários online a 10 participantes em junho de 2022, utilizando também entrevistas, observações e pesquisa documental. A análise de conteúdo revelou que as sessões no planetário impactaram positivamente o aprendizado sobre física e astronomia, aumentando significativamente o conhecimento e despertando interesse. Os resultados destacam o papel crucial do planetário como ambiente educacional, ampliando a compreensão científica e estimulando a aprendizagem nessas áreas. Apesar do interesse na matéria escura, observou-se disparidade no conhecimento prévio dos participantes, evidenciando a necessidade de estratégias educacionais e de divulgação científica. O estudo enfatiza os espaços não-formais como ferramentas eficazes na disseminação do conhecimento científico, promovendo interesse e compreensão. Limitações, como o tamanho da amostra e subjetividade, são consideradas. Os resultados contribuem para aprimorar atividades de divulgação científica, destacando a importância da análise de relatos de visitantes em ambientes como planetários. Em suma, o planetário emerge como agente transformador na relação da comunidade com astronomia, ciência e cultura.
Insetos como instrumento de aprendizagem no ensino de ciências
Authors: Layonn de Sousa Silva John , José Fontenele Oliveira Rômulo , Henrique da Silva Sousa Carlos
Published: August 2024

Resumo: A grande quantidade existente dentro do leque entomológico, permite que os insetos sejam ferramentas de grande importância para o ensino de ciências como um todo, possibilitando interdisciplinaridade. Neste sentido, foi despertada a necessidade de buscar se os insetos são e como vêm sendo utilizados pelos docentes em sala de aula e no ensino de ciências do ensino base. Desta forma foi objetivado a utilização dos insetos como ferramenta de ensino aprendizagem. Foi optado por uma pesquisa qualitativa, revisão bibliográfica, artigos, periódico da CAPES, SCielo e repositórios acadêmicos de instituições públicas e, nacionais, de preferência a língua portuguesa, sobre  utilização dos insetos no ensino de ciências, partindo de pontos de vista onde é  exposto à visão de autores sobre a importância de trabalhar o saber entomológico no ensino, e o significado de ensinar de forma objetiva e científica, rompendo as limitações do ambiente de sala de aula e difundindo conceitual sobre o temática. Partiu-se da ideia de que os professores devem trabalhar os conteúdos, dentro de suas disciplinas e independente de qualquer que seja o conteúdo, buscar de forma interdisciplinar agregar conhecimentos sobre ciências. Concluímos que que a utilização entomológica como ferramenta de ensino, tem sido alvo de docentes no ensino de ciências, e que esta tática permite uma ampla abrangência no tocante ao aprendizado. Os artigos trabalhados apontam resultados de aceitação pelos discentes e ainda possibilita uma adequação cognitiva, dando aos mesmos uma nova perspectiva científica e que não se prende somente ao livro didático.
Palavras- chave: Insetos, Ensino, Ciências.
Percepção de licenciandos sobre as imagens: contribuições para a formação de professores
Authors: Oestreich Laura , Goldschmidt Andréa Inês
Published: August 2024

Este artigo tem como objetivo investigar como licenciandos de Ciências da Natureza percebem o emprego de imagens e a sua influência nos processos de ensino e de aprendizagem, buscando subsidiar discussões e cursos de formação voltados para a temática. A pesquisa qualitativa, abrangeu um questionário realizado via Google Forms com 41 licenciandos. As questões foram analisadas de acordo com Análise de Conteúdo. Os resultados sinalizaram que para a maioria dos respondentes as imagens são sempre ou geralmente empregadas e buscadas principalmente na internet, cumprindo funções de facilitadoras do ensino-aprendizagem, além de tornar as aulas mais dinâmicas.  São recursos autoexplicativos e embora a maioria sinalize que possui critérios para selecioná-las, uma parcela significativa, não os possui ou admitiu nunca ter pensado sobre, denotando uma visão ingênua e a necessidade da inserção deste tema no percurso formativo docente.
Thermal inkjet makes label-free single-cell proteomics accessible and easy
Authors: Stanisheuski Stanislau , Ebrahimi Arpa , Vaidya Kavi Aashish , Jang Hyo Sang , Yang Liping , Eddins Alex Jordan , Marean-Reardon Carrie , Franco Maria Clara , Maier Claudia Susanne
Published: August 2024

In this study, we adapted an HP D100 Single Cell Dispenser – a novel low-cost thermal inkjet (TIJ) platform with impedance-based single cell detection – for dispensing of individual cells and one-pot sample preparation. We repeatedly achieved label-free identification of up to 1,300 proteins from a single cell in a single run using an Orbitrap Fusion Lumos Mass Spectrometer coupled to either an Acquity UPLC M-class system or a Vanquish Neo UHPLC system. The developed sample processing workflow is highly reproducible, robust, and applicable to standardized 384- and 1536-well microplates, as well as glass LC vials. We demonstrate the applicability of the method for proteomics of single cells from multiple cell lines, mixed cell suspensions, and glioblastoma tumor spheroids. As additional proof of robustness, we monitored the results of genetic manipulations and the expression of engineered proteins in individual cells. Our cost-effective and robust single-cell proteomics workflow can be transferred to other labs interested in studying cells at the individual cell level.
Performance of metagenomic Next-Generation Sequencing and metagenomic Nanopore Sequencing for the diagnosis of tuberculosis in HIV-positive patients
Authors: Yuan Jing , Wang Lanchun , Zhang Wei , Deng Changgang , Li Qisui , Meng Yamin , Chen Yaokai
Published: August 2024

Background

Patients who were infected by the Human Immunodeficiency Virus (HIV) could have weakened immunity that is complicated by opportunistic infections, especially for Mycobacterium tuberculosis (MTB). Notably, the HIV-MTB co-infection will accelerate the course of disease progress and greatly increase the mortality of patients. Since the traditional diagnostic methods are time-consuming and have low sensitivity, we aim to investigate the performance of mNGS (metagenomic Next-Generation Sequencing) and mNPS (metagenomic NanoPore Sequencing) for the rapid diagnosis of tuberculosis in HIV-infected patients.

Methods

The 122 HIV-infected patients were enrolled for the retrospective analysis. All of the patients underwent traditional microbiological tests, mNGS, and (or) mNPS tests. The clinical comprehensive diagnosis was used as the reference standard to compare the diagnostic performance of culture, mNGS, and mNPS on tuberculosis. We also investigate the diagnostic value of mNGS and mNPS on mixed-infection. Furthermore, the treatment adjustment directed by mNGS and mNPS was analyzed.

Results

Compared with the composite reference standard, the culture showed 42.6% clinical sensitivity and 100% specificity, and the OMT(other microbiological testing) had 38.9% sensitivity and 100% specificity. The mNGS had 58.6% clinical sensitivity and 96.8% specificity, and the mNPS had 68.0% clinical sensitivity and 100% specificity. The proportion of mixed-infection cases (88.9%) in the TB group was higher than those in the non-TB group (54.8%) and the mNGS and mNPS are more competitive on mixed-infection diagnosis compared with the traditional methods. Furthermore, there are 63 patients (69.2%) and 36 patients (63.2%) achieved effective treatment after receiving the detection of mNPS and mNGS, respectively.

Conclusion

Our study indicated that mNPS and mNGS have high sensitivity and specificity for TB diagnosis compared with the traditional methods, and mNPS seems to have better diagnostic performance than mNGS. Moreover, mNGS and mNPS showed apparent advantages in detecting mixed infection. The mNPS and mNGS-directed medication adjustment have effective treatment outcomes for HIV-infected patients who have lower immunity.
Blurring bioart boundaries
Authors: Pietarinen Heidi , Qureshi Amna
Published: August 2024

This study investigates the intersection of bioart and posthumanistic perspectives through the innovative use of reindeer by-products, specifically reindeer blood, as a medium for artistic expression. Utilising an Arts-Based Research (ABR) approach, the research investigates the methodological, ethical, and cultural dimensions of integrating waste materials into creative practices. The project repurposes reindeer blood, an often-overlooked by-product of reindeer herding, to provoke ethical discussions on sustainability and cultural sensitivity within the arts. Experiments in the BioARTech laboratory transform reindeer blood into air-dried pigment, which is then incorporated into glassblowing and surface pattern design. These innovative techniques challenge traditional boundaries of artistic materials and prompt deeper reflections on human-nature relationships. Exhibitions across Finland highlight the ethical application of this unique Northern material, highlighting its cultural significance and promoting a reimagining of our interconnectedness with the natural world. Ultimately the study expands the artistic repertoire and advocates for more harmonious and sustainable futures through pioneering bioart practices.
A novel nomogram for predicting the recurrence of atrial fibrillation in patients treated with first-time radiofrequency catheter ablation for atrial fibrillation
Authors: Ma Guiling , Zou Changhong , Zhang Zhiyong , Zhang Lin , Zhang Jianjun
Published: August 2024

Introduction

The purpose of this study was to investigate the predictive factors of atrial fibrillation (AF) recurrence in patients after first-time radiofrequency catheter ablation (RFCA) and to develop a nomogram predictive model that can provide valuable information for determining the ablation strategy.

Methods

In total, 500 patients who had received first-time RFCA for AF were retrospectively enrolled in the study. The patients were divided into a training cohort (n = 300) and a validation cohort (n = 200) randomly at a 6:4 ratio. Lasso and multivariate logistic regression analyses were used to screen the predictors for AF recurrence during a 2-year follow-up. The C-index and a calibration plot were used to detect the discriminative ability and calibration of the nomogram. The performance of the nomogram was assessed compared with the APPLE score, CAAP-AF score, and MB-LATER score using the receiver operating characteristic (ROC) curve, decision curve analysis (DCA), integrated discrimination index (IDI), and net reclassification index (NRI).

Results

A total of 78 patients experienced the recurrence of AF after first-time RFCA in the training cohort. The six strongest predictors for AF recurrence in the training cohort were persistent AF, duration of AF, left atrial diameter (LAD), estimated glomerular filtration rate (eGFR), N-terminal pro-brain natriuretic peptide (NT-proBNP), and autoantibody against M2-muscarinic receptor (anti-M2-R). Based on the above six variables, a nomogram prediction model was constructed with a C-index of 0.862 (95% CI, 0.815–0.909), while the C-index was 0.831 (95% CI, 0.771–0.890) in the validation cohort. DCA showed that this nomogram had greater net benefits compared with other models. Furthermore, the nomogram showed a noticeable improvement in predictive performance, sensitivity, and reclassification for AF recurrence compared with the APPLE score, CAAP-AF score, or MB-LATER score.

Conclusion

We established a novel predictive tool for AF recurrence after the first-time RFCA during a 2-year follow-up period that could accurately predict individual AF recurrence.
The left axillary artery is a reasonable option as the inflow site for saphenous vein graft in minimally invasive coronary artery bypass grafting
Authors: Ushioda Ryohei , Hirofuji Aina , Yoongtong Dit , Sakboon Boonsap , Cheewinmethasiri Jaroen , Lokeskrawee Thanin , Patumanond Jayanton , Lawanaskol Suppachai , Kamiya Hiroyuki , Arayawudhikul Nuttapon
Published: August 2024

Introduction

This study aims to clarify the good inflow site for saphenous vein grafts (SVG) in minimally invasive off-pump coronary artery bypass grafting (mini-CABG), between the ascending aorta, the internal thoracic arteries (ITAs) and the left axillary artery (LAA).

Methods

This retrospective study included 126 patients who underwent Mini-CABG at our center between January 2014 and July 2023. Patients were divided into three groups according to the SVG inflow site for patency comparison: Aorta group (n = 56), LAA group (n = 23), and ITA group (n = 47).

Results

There were 84 males, with mean age of 65.9 ± 7.0 years. There were no significant differences in preoperative characteristics between groups. Mean operation times were 254.6 ± 72.2, 213.7 ± 57.6, and 253.0 ± 81.2 min, and the average numbers of distal anastomoses were 2.9 ± 0.9, 2.4 ± 0.7 and 2.9 ± 1.1 in the Aorta, ITA and LAA groups respectively. Days in intensive care, hospital stay, and major complications did not differ between the groups. Early patency of SVG did not significantly differ among groups: 93.0% in the Aorta group, 98.0% in the ITA group, and 100% in the LAA group. Mean follow-up period was 136.7 ± 295.7 days, and follow-up coronary CTA revealed 18 SVG occlusions (Aorta group n = 8, ITA group n = 5, LAA group n = 5). The Kaplan-Meier curve for SVG patency rates did not show any significant differences among the three groups.

Conclusion

The ascending aorta, the ITAs, and the LAA serve as reliable inflow sites with similar results in mini-CABG.
Study of response characteristics of cross-well induced polarization method in anisotropic media
Authors: Junke Zhang , Lei Zhou , Xinyu Wang , Xingbing Xie , Yurong Mao , Liangjun Yan
Published: August 2024

The borehole induced polarization method has been widely used in deep mineral exploration, oil and gas resource exploration, and water resource exploration because of its high efficiency and good exploration effect. At present, the related research on the cross-well induced polarization method assumes that the underground medium is isotropic, but the electrical characteristics of the actual earth medium are anisotropic. To analyze the influence of the anisotropic characteristics on the cross-well induced polarization method, in this paper, the anisotropic forward algorithm of conductivity and polarizability in different principal axis directions based on the finite element method is studied. A three-dimensional forward simulation of the cross-well induced polarization method in anisotropic media is realized. The effectiveness and correctness of the algorithm are verified by testing and comparing complex 3-D isotropic and anisotropic models. Anisotropic geological models of the horizontal plate and inclined plate are constructed to analyze the anisotropic influences of conductivity and polarizability in different principal axis directions on the cross-well induced polarization response. The results show that the emitter sources with different depths in the well have different influences on the electrical response of the plates. Anisotropic conductivity and polarizability in horizontal plates exhibit most pronounced characteristics in the x-direction, significantly influencing the apparent polarizability curves. However, when the resistivity and polarizability are both anisotropic, the change in the z-direction is the most complicated. When the plate is inclined, the amplitude of the electrical response curve decreases to a certain extent, and the position where the amplitude appears shifts to different degrees. Notably, the response curves of the y-direction anisotropy are basically consistent with the response curves of the isotropy, regardless of the anisotropy of the conductivity and polarizability or anomalous body tilts. The results of this study improve our understanding of the influence of anisotropy on cross-well induced polarization and provide theoretical support for the interpretation of cross-well induced polarization data considering anisotropy.
Co-creating academic career self-efficacy: exploring academic career segments, mediating and moderating influences in engineering education trajectory
Authors: Mahajan Prashant
Published: August 2024

Introduction

This study explores the dynamic relationship among different academic career stages within engineering education, using academic career self-efficacy (ACSE) – one’s belief in their academic ability, as the unitary construct. The purpose of this study was to examine the relationships between the academic career segments demonstrating self-efficacy at the beginning of career, during academic progression, and post-graduation completion, along with the mediating and moderating effects corresponding to the relationships.

Methods

Quantitative survey was conducted on Indian recent engineering graduates. Data was collected from closed-ended questionnaire. Structural equation modeling was employed to analyze the relationships among academic career segments, mediation and the moderating impact of personal traits.

Results

There were statistical significances among the relationships between academic career segments with each other. Notably, ACSE during academic progression emerged as a crucial mediator between entry-level ACSE and ACSE post-graduation completion. Furthermore, gender, social caste, engineering major, campus placement and engineering grade were identified as significant moderators for these relationships.

Discussion

It sheds light on the significance of ACSE throughout diverse academic career segments enhancing career aspirations, engineering skills, and expressions and reflections that facilitate collaborative co-creation for engineering as a career. It contributes to the positive propagation of engineering education as an excellent and rewarding career choice.
Examining the role of family sociology, managerial support, and working conditions in determining teacher performance in Indonesia: the mediating role of motivation and professional development
Authors: Ulfah Maria , Syahrudin Husni , Thoharudin Munawar , Wardani Sandra Fitria , Kholifah Nur
Published: August 2024

In developing countries like Indonesia, responsible agencies have yet to consider in-depth factors in building better teacher performance in secondary education. Contemporary educational research has explored the relationship between motivation and professional development on teacher performance. However, there needs to be more understanding of this relationship with family sociological conditions, levels of managerial support, and different working conditions. This research examines how motivation and professional development can determine teacher performance by involving these three conditions. This research involved 474 secondary education teachers voluntarily and with specific criteria profiles tailored to their needs. Data collection was assisted using a closed questionnaire with a four-point Likert scale, tested for validity and reliability. Structural Equation Modeling was used to analyze data through path analysis and bootstrap methods. The findings prove the importance of motivation and professional development supported by family sociological conditions, managerial support, and proportional workload in determining teacher performance. These results shed light on secondary education providers in strengthening professional development and simultaneously strengthening teacher motivation which has so far often been overlooked. The strategy used is to provide support in the managerial aspect to create work comfort and a proportional workload to make it easier for teachers to carry out technical development. Lastly, support and positive relationships from the family contribute to strengthening the teacher’s mentality which leads to strengthening work motivation. In conclusion, teacher performance in secondary education can be optimal by carrying out self-development, strengthening motivation, proportional performance, in addition to managerial and family support in establishing mental health.
Enhancing the health and wellbeing benefits of biodiversity citizen science
Authors: Oh Rachel R. Y. , Fuller Richard A. , Peters Birte , Dean Angela J. , Pachana Nancy A. , Callaghan Corey T. , Sockhill Nicola J. , Bonn Aletta , Suarez-Castro Andres F.
Published: August 2024

Engagement in biodiversity citizen science initiatives can confer health and wellbeing benefits to individuals and communities. Yet, few biodiversity citizen science initiatives are explicitly planned to optimize health and wellbeing as a potential co-benefit, leading to missed opportunities for biodiversity conservation and human health. In this perspective, we use a dose-response approach to discuss the components that determine how engagement in biodiversity citizen science initiatives map onto opportunities to foster health and wellbeing benefits. We considered aspects related to the duration and frequency of contact with nature, and the intensity of interactions with nature and between individuals to highlight the different health benefits across the variety of citizen science initiatives. To illustrate these aspects, we use a sample of 95 citizen science initiatives from seven English and non-English-speaking countries and show how careful project design can increase the potential to confer health and wellbeing benefits to participants. We conclude with considerations on how to enhance the health and wellbeing benefits from citizen science initiatives, and propose potential research avenues to assess synergies and trade-offs between benefits to biodiversity and human health from these initiatives.
Inflammatory cytokine expression in Fabry disease: impact of disease phenotype and alterations under enzyme replacement therapy
Authors: Yuan Yujing , Zhao Yawen , Li Fan , Ling Chen , Wu Yuan , Ma Wei , Wang Zhaoxia , Yuan Yun , Hao Hongjun , Zhang Wei
Published: August 2024

Objectives

The aim of this study is to explore the expression of inflammatory cytokines (ICs) in Fabry disease (FD), the correlation between ICs and FD phenotypes, and the impact of enzyme replacement therapy (ERT) on IC expression.

Methods

We recruited 67 FD patients and 44 healthy controls (HCs) and detected concentrations of the following ICs: interferon-γ, interleukin (IL)-1β, IL-2, IL-4, IL-5, IL-6, IL-8, IL-10, IL-12P70, IL-17A, IL-17F, IL-22, tumor necrosis factor (TNF)-α, and TNF-β. We also analyzed the impact of ERT on IC expression in FD patients and the relationship between IC expression and sex, genotype, phenotype, disease burden, and biomarkers.

Results

Most ICs were significantly higher in FD patients than in HCs. A number of ICs were positively correlated with clinical aspects, including disease burden (Mainz Severity Score Index [MSSI]) and cardiac and renal markers. IL-8 was higher in the high MSSI (P-adj=0.026*) than in the low MSSI.

Conclusions

ICs were upregulated in FD patients, indicating the role of the innate immune process in FD etiology. ERT ameliorated FD-related inflammatory activation, at least to some extent. IC expression was positively correlated with disease burden and clinical markers in FD. Our findings indicated that the inflammatory pathway may be a promising therapeutic target for FD.
SARS-CoV-2 spike protein antibody titers after the fourth dose of BNT162b2 vaccine among Japanese patients undergoing hemodialysis: a single-center study
Authors: Watanabe Shun , Sawano Toyoaki , Saito Hiroaki , Ozaki Akihiko , Wakui Masatoshi , Zhao Tianchen , Yamamoto Chika , Kobashi Yurie , Kawamura Takeshi , Sugiyama Akira , Nakayama Aya , Kaneko Yudai , Shimmura Hiroaki , Tsubokura Masaharu
Published: August 2024

Patients undergoing hemodialysis are particularly vulnerable to severe outcomes of SARS-CoV-2 infection, with mortality rates higher than that of the general population. Vaccination reduces the risk of adverse outcomes, with booster doses being particularly beneficial. However, limited data are available on the effectiveness of subsequent vaccinations or their effect on increasing antibody levels. This single-center study aimed to investigate changes in SARS-CoV-2 IgG antibody titers following the fourth vaccination among 28 patients undergoing hemodialysis. Blood tests were conducted at various intervals post-vaccination, with a focus on identifying factors associated with antibody levels. The IgG antibody levels rapidly increased by Day 7 post-vaccination, with a median time to peak of 11 days. Antibody titers tended to be higher in male patients than in female patients. This study sheds light on the immune response to the fourth vaccination in patients undergoing hemodialysis. As this study included a small sample size, with a short observation period, further research is warranted to comprehensively understand the effectiveness of vaccination and the benefits of additional doses of vaccine.
Integrating single-cell transcriptomics to reveal the ferroptosis regulators in the tumor microenvironment that contribute to bladder urothelial carcinoma progression and immunotherapy
Authors: Chen Ziang , Hu Jia , Ou Yuxi , Ye Fangdie , Li Weijian , Liu Shenghua , Jiang Haowen
Published: August 2024

Background

Ferroptosis, as a novel form of programmed cell death, plays a crucial role in the occurrence and development of bladder cancer (BCa). However, the regulatory mechanisms of ferroptosis in the tumor microenvironment (TME) of BCa remain to be elucidated.

Methods

Based on single-cell RNA (scRNA) transcriptomic data of BCa, we employed non-negative matrix factorization (NMF) dimensionality reduction clustering to identify novel ferroptosis-related cell subtypes within the BCa TME, aiming to explore the biological characteristics of these TME cell subtypes. Subsequently, we conducted survival analysis and univariate Cox regression analysis to explore the prognostic significance of these cell subtypes. We investigated the relationship between specific subtypes and immune infiltration, as well as their implications for immunotherapy. Finally, we discovered a valuable and novel biomarker for BCa, supported by a series of in vitro experiments.

Results

We subdivided cancer-associated fibroblasts (CAFs), macrophages, and T cells into 3-5 small subpopulations through NMF and further explored the biological features. We found that ferroptosis played an important role in the BCa TME. Through bulk RNA-seq analysis, we further verified that ferroptosis affected the progression, prognosis, and immunotherapy response of BCa by regulating the TME. Especially ACSL4+CAFs, we found that high-level infiltration of this CAF subtype predicted worse prognosis, more complex immune infiltration, and less response for immunotherapy. Additionally, we found that this type of CAF was associated with cancer cells through the PTN-SDC1 axis, suggesting that SDC1 may be crucial in regulating CAFs in cancer cells. A series of in vitro experiments confirmed these inferences: SDC1 promoted the progression of BCa. Interestingly, we also discovered FTH1+ macrophages, which were closely related to SPP1+ macrophages and may also be involved in the regulation of BCa TME.

Conclusion

This study revealed the significant impact of ferroptosis on bladder cancer TME and identified novel ferroptosis-related TME cell subpopulations, ACSL4+CAFs, and important BCa biomarker SDC1.
Immunotherapy for colorectal cancer
Authors: Yu Bing , Kang Jian , Lei Hong , Li Zhe , Yang Hao , Zhang Meng
Published: August 2024

Colorectal cancer is the third most common cancer and the second most lethal cancer in the world. The main cause of the disease is due to dietary and behavioral factors. The treatment of this complex disease is mainly based on traditional treatments, including surgery, radiotherapy, and chemotherapy. Due to its high prevalence and high morbidity, more effective treatments with fewer side effects are urgently needed. In recent years, immunotherapy has become a potential therapeutic alternative and one of the fastest-developing treatments. Immunotherapy inhibits tumor growth by activating or enhancing the immune system to recognize and attack cancer cells. This review presents the latest immunotherapies for immune checkpoint inhibitors, cell therapy, tumor-infiltrating lymphocytes, and oncolytic viruses. Some of these have shown promising results in clinical trials and are used in clinical treatment.
Deciphering the causal association and underlying transcriptional mechanisms between telomere length and abdominal aortic aneurysm
Authors: Zhang Jiyu , Xia Xinyi , He Shujie
Published: August 2024

Background

The purpose of this study is to investigate the causal effect and potential mechanisms between telomere length and abdominal aortic aneurysm (AAA).

Methods

Summary statistics of telomere length and AAA were derived from IEU open genome-wide association studies and FinnGen R9, respectively. Bi-directional Mendelian randomization (MR) analysis was conducted to reveal the causal relationship between AAA and telomere length. Three transcriptome datasets were retrieved from the Gene Expression Omnibus database and telomere related genes was down-loaded from TelNet. The overlapping genes of AAA related differentially expressed genes (DEGs), module genes, and telomere related genes were used for further investigation. Telomere related diagnostic biomarkers of AAA were selected with machine learning algorisms and validated in datasets and murine AAA model. The correlation between biomarkers and immune infiltration landscape was established.

Results

Telomere length was found to have a suggestive negative associations with AAA [IVW, OR 95%CI = 0.558 (0.317-0.701), P < 0.0001], while AAA showed no suggestive effect on telomere length [IVW, OR 95%CI = 0.997 (0.990-1.004), P = 0.4061]. A total of 40 genes was considered as telomere related DEGs of AAA. PLCH2, PRKCQ, and SMG1 were selected as biomarkers after multiple algorithms and validation. Immune infiltration analysis and single cell mRNA analysis revealed that PLCH2 and PRKCQ were mainly expressed on T cells, while SMG1 predominantly expressed on T cells, B cells, and monocytes. Murine AAA model experiments further validated the elevated expression of biomarkers.

Conclusion

We found a suggestive effect of telomere length on AAA and revealed the potential biomarkers and immune mechanism of telomere length on AAA. This may shed new light for diagnosis and therapeutics on AAA