bluuebunny/crossref_metadata_2025 huggingface dataset:
Lung and Mediastinal Tumor Core Biopsies: Histopathological Features of 320 Cases
Authors: Dhiya Ul Haq Alyaa Ulaa , Kusumastuti Etty Hary , Kurniasari Nila , Anang Marhana Isnin
Published: October 2023

Histopathological diagnosis is needed to determine the most appropriate prognosis and therapy for lung and mediastinal tumors, one of the procedures to obtain specimens needed for the examination is a core biopsy. However, core biopsy still requires further evaluation regarding the accuracy and benefits of the technique. This study aims to determine the histopathological features of core biopsy specimens in lung and mediastinal tumors. Designed as a descriptive study using a retrospective approach, we collected medical records of core biopsy results in patients with lung and mediastinal tumors diagnosis at Dr. Soetomo Hospital Surabaya, Indonesia during 1st July 2015-30th June 2020 with total sampling. Of the total 320 cases, 67.8% (n=217) lesions were found in the lung and 32.2% (n=103) in the mediastinum. The most common age distribution for lung tumors was 51-60 years old (34.6%, n=75), while mediastinal tumors were 11-20 years old (20.4%, n=21). Male were more common, both in lung tumors (77.0%, n=167) and mediastinal tumors (61.2%, n=63). The most common histopathological features of lung tumors were lung adenocarcinoma (46.5%, n=101), while in the mediastinum was indeterminate (41.7%, n=43). The age profile of lung tumors is different from that of mediastinal tumors, both are dominated by male. The core biopsy procedure is very useful in establishing the diagnosis of lung and mediastinal tumors. In the indeterminate result, the tissue sample obtained through the core biopsy procedure allows for further molecular examinations including immunohistochemistry, so that a definitive diagnosis can be established.
The growth of ETV6-NTRK3 harbouring cells was inhibited by Artemisia vulgaris L. crude extract
Authors: Thanh Chi Hoang , Tram Vo ngoc , Trung Quan Nguyen , Kim Ly Bui Thi
Published: October 2023

Artemisia vulgaris L. has a long history of use in traditional medicine for the treatment of a wide range of ailments. Advancements in science and technology established scientific evidence for this medicinal plant. Recent studies have shown that A. vulgaris inhibits the growth of numerous cancer cell lines, including MCF-7, HepG2, Hela, and K-562. To access the potential anti-leukemia activity of A. vulgaris crude methanol extract (MetAV) on the ETV6-NTRK3-carrying cells, the IMS-M2, MO-91, and BaF3-CFS cell lines were co-cultured with MetAV for 48 h before being stained with Trypan Blue to calculate the percentage of viable cells. With IC50 values of 26.98 ± 2.25; 21.85 ± 0.92; and 18.70 ± 1.70 µg/ml for IMS-M2, MO-91, and BaF3-CFS, respectively, the results indicated that MetAV had a significant effect on the examined cells.
Synthesis, Characterization and In vitro Antimicrobial Assessments of a New Series Benzoimidazoles Incorporated Quinazoline and Thiazine Analogues.
Authors: Kareem Khan Ayad
Published: October 2023

In this study, several aromatic groups were inserted to synthesize various4-oxo-1,4-dihydroquinazolin [4a-f] and 4-oxo-2H-benzo[1,3]thiazin[5a-f] linked to benzoimidazole rings. The chemical structures of the synthesized benzoimidazole derivatives were corroborated by physicochemical properties, elemental micro analysis (C,H,N) and some spectroscopic techniques such as (FTIR, 1H-NMR, 13C-NMR). In vitro antimicrobial assessmentfor newly synthesized target compounds against six types of pathogenic bacteria and one type of fungi was investigated which is comparable to azithromycin (as antibacterial), Itraconazole (antifungal) reference drugs.The results obtained showed that most of the compounds have a potential good to medium activity against these different types of microorganisms.
Formulation development and in vitro evaluation of provesicular gel of ketoprofen for management of Arthritis
Authors: Madhariya Rashmi , Ram Alpana
Published: October 2023

The fundamental principles and uses of transdermal drug delivery, which is a method for therapeutic drug delivery through the skin as an alternative to oral, intravascular, subcutaneous, and transmucosal routes. Arthritis is a chronic condition that affects nearly a quarter of the United States population. Osteoarthritis (OA) and rheumatoid arthritis (RA) are two major forms of arthritis associated with severe joint pain and reduced quality of life. Various pharmacological interventions may be utilized for arthritis treatment when non-pharmacological therapy is insufficient. However, pharmacological therapy can be associated with serious side effects and high costs. Therefore, alternative therapies have been under investigation. Some (details in tables) medications have shown the potential for safe and effective management of arthritis. this review, we attempt to summarize the mechanisms, diagnosis, treatments, clinical significant for OA and RA and all type of arthritis.

The present study aims to formulate and evaluate the effectiveness of vesicular gel of ketoprofen in induced animal model. In the present work, optimization formulations of vesicular gel were prepared. Lecithin was used as polymers. The vesicular gel containing drugs and excipients were subjected to various evaluation test such as Preformulation study of drug, Particle size distribution, Morphology, Photomicroscope, Transfusion, SEM,TEM, In vitro, and Kinetic release. Various kinetic models to evaluate correlation coefficient and release rate constant. It was found that for the formulation, value of correlation coefficientof Korsemmayer Peppas equation is nearer to 1.0 and hence it can be predicted that the release from prodeformable vesicles follow Korsemmayer Peppas kinetics.
FTIR Method for Simultaneous determination of Captopril and Hydrochlorothiazid in Raw material and Pharmaceutical Dosage Form
Authors: Mhammad Ali , Trefi Saleh , Sliman Faten , Bitar Yaser
Published: October 2023

A New FTIR method was developed and validated to simultaneous determination of Captopril (CAP) and Hydrochlorothiazid (HCTZ) in raw material and pharmaceutical dosage forms. The method includes preparation of solid pellets of hydrochlorothiazide and captopril using KBr and the quantitative determination peaks were chosen after conducting an excipient interference study. Then, the validation method was carried out according to the ICH guidelines. The calibration curve was developed using spectral region from 3115.92-3222.1 cm-1 for HCTZ and 1689.91-1800.73 cm-1 for CAP by plotted the peak height (intensity) for the selected peaks against the concentrations where, there are no overlapping with excipients used in the preparation of tablet dosage form. Captopril and Hydrochlorothiazid were detected in the following linear ranges: (0.4-2% w/w) and (0.4-2% w/w); respectively with excellent coefficeients of determination (R2), 0.9989 and 0.9982. Accuracy was found with excellent mean recovery values (98.0–102.0%). The precision showed RSD% was in a satisfactory range (< 2), evidencing the precision of the developed method. In Conclusion this method was inexpensive, environmental friendly and can be employed for simultaneous estimation of CAP and HCTZ in solid dosage forms.
Monocrotaline model of Pulmonary hypertension in immature rats from the perspective of Serotonergic regulation
Authors: F. Bilalova Diana , A. Mindubayeva Farida , R. Nigmatullina Razina , Y. Salikhova Yelena
Published: October 2023

Pulmonary hypertension (PH) is a multifactorial disease characterized by an average pulmonary artery pressure of 25mmHg or higher. Although PH is generally classified into five distinct groups, pulmonary arterial hypertension (PAH), especially the idiopathic subgroup (IPAH) or congenital heart disease (CHD) subgroup, has been the focus of most of our research from a serotonergic regulatory perspective. There are many models of pulmonary hypertension in experimental practice. Each model aim at certain goals and is based on various mechanisms. The monocrotaline model of pulmonary hypertension is one of the best models for studying pulmonary hypertension due to endothelial dysfunction. However, in experimental practice, this model is used only for adulthood. At present, the influence of the serotonergic system is not taken into account in the treatment of children with pulmonary hypertension. We have modified the monocrotaline model of pulmonary hypertension for immature rats. A positive correlation was found between the concentration of serotonin metabolites in the urine and the degree of pulmonary hypertension, which can become a potential marker of pulmonary hypertension.
Melt granulation for Enhanced Dissolution Rate and Antimicrobial activity of Cefpodoxime Proxetil
Authors: Abdel Kader Nouran , Abo Kamer Amal , Elekhnawy Engy , Arafa Mona , A Essa Ebtessam , M El Maghraby Gamal
Published: October 2023

The aim of this work was to improve dissolution rate and antibacterial activity of cefpodoxime proxetil (CP) by Pluronic PE 6800 (Poloxamer 188) as eutectic forming hydrophilic polymer. CP was incorporated in the polymer by melt granulation technique. CP was mixed with melted polymer before addition of Avicel, in absence and presence of HPMC E6, with mixing to provide flowable particles. The formulations were characterized using thermal analysis and Fourier transform infrared spectroscopy (FTIR) in addition to dissolution studies. The antibacterial activity of CP against Proteus mirabilis was also explored. FTIR suggested possible hydrogen bonding between CP and polymers. All formulations improved CP dissolution compared to unprocessed CP. This could be attributed to the formation of eutectic species, as reflected by thermal analysis as new endothermic peak at Tm value of 40°C was detected in thermograms of all tested formulations. Microbiological investigations indicated that the optimized formulation offered advantages over pure CP with reduced minimum inhibitory concentration. Additionally, formulated CP decreased the biofilm formation ability among the tested P. mirabilis clinical isolates relative to unprocessed CP. The study introduced melt granulation of CP with poloxamer 188 as a promising tool for enhanced dissolution and augmented activity against Proteus mirabilis with capacity to minimize the biofilm formation.
Antibacterial study of the Ethanolic extract of local common Myrtle leaves Myrtus communis L. (Myrtaceae)
Authors: Islim Yazan , Muhammad Dima
Published: October 2023

This study aims to investigate the antibacterial activity of the ethanolic extract of common myrtle “Myrtus communis Linn.” leaves (Myrtaceae), specifically against Escherichia coli and Staphylococcus aureus isolated from patients at Tishreen University Hospital, Syria. Leaves were subjected to ultrasound-assisted extraction using the distilled-ethanol as a solvent. The dried extract, with a yield of 25.3%, was dissolved in two types of solvent Dimethylsolfoxide (DMSO), and a mixture of Tween 80 solution 10% and DMSO 8:2 and then tested for antibacterial activity using the standard disk diffusion technique. In this work, DMSO showed better properties in the improvement of the solubility and the diffusion of the prepared extract, thus enhancing its antibacterial action.The inhibition zones showed that the tested ethanolic extract has interesting activity against both tested strains with higher activity towards S. aureus.The overall results encourage the application of this extract to combat bacterial resistance, and as an additive in the food industry to control the foodborne disease caused by S. aureus.
Kur’an Kıssalarında İtikadi Motifler
Authors: BAL Samet Yahya
Published: October 2023

Kur’an’ı Kerim’in bütünlüğü içerisinde kıssalar önemli bir yekûn teşkil etmektedir. Ayrıca kıssalar Kur’an’ın diğer bölümleriyle kıyaslandığında içerik olarak aynı esasları ve konuları ihtiva ettiği görülmektedir. Kur’an’daki kıssalar gerçeklik ve hak oluşunun kabulü bağlamında ahlaki, hukuki, fıkhi ve tarihi açıdan birçok değerlendirmeye tabi tutulmuştur. Kıssaların içerdiği esasların temel itikadi parametreleri ihtiva etmesi kıssaların gerçekliği ve kelami açıdan nasıl bir değere sahip olduğu hususunu akla getirmektedir. Çalışmada Kur’an kıssalarındaki itikada taalluk eden noktalar üzerinde durulup, kıssalara karşı kelami bir bakış ortaya konulmaya çalışılmıştır.
Motion Verbs in Italian and the Manner/Direction Complementarity
Authors: Vietri Simonetta
Published: October 2023

This paper presents an empirical analysis of Italian directed motion verbs and manner of motion verbs; the research is based on a lexical resource of 234 verbs subdivided into six classes. Directed motion verbs are analysed according to their argument structure and to the type of path PP they take: both source and goal PPs, only source PPs or only goal PPs. Furthermore, I have highlighted how the morphological, distributional and semantic properties of these verbs have an impact on their argument structure.Manner of motion verbs are analysed according to their unaccusative/unergative structure and on the semantic components they entail: only Manner or Manner and Direction. Analysis of the data shows that the semantics of both types of motion verbs depends in many cases on the distributional context in which they occur. As a result, it is not always an easy task to generalize the semantic components the verbs lexicalize. The Italian data also show that, contrary to the hypothesis proposed by Rappaport Hovav & Levin (2010) and Levin & Rappaport Hovav (2013) on the opposition between manner and direction, a subset of Italian motion verbs encodes both manner and direction. Moreover, the Italian lexicon shows an abundance of manner of motion verbs that can resort to a satellite-framed strategy, suggesting that the clearcut opposition between satellite-framed and verb-framed languages claimed in Talmy (1985) boils down to a tendency.
The Lexico-grammatical Ecology of Media Arabic Genre: A Multi-dimensional Analysis
Authors: Azennoud Zakariae
Published: October 2023

Media Arabic is a linguistically independent genre of Modern Standard Arabic. There are a number of explanatory reasons accounting for a characterized, integrally structured media Arabic form. Much within our scientific grasp is the overall combination of lexico-grammatical traits, constituting a major part of the internal textual ecology. Within our reach, again, there is parsimonious literature hardly informing, or predicting, what situationally and linguistically a media Arabic text is. The vast body of research is intuition-governed and prescriptive. This paper is a concise exposition of a work endeavoring to fill out such a gap in research. It summarizes the findings of a large-scale project in Arabic corpus linguistics that empirically investigates media Arabic genre from a functional lexico-grammatical perspective, by using Multi-Dimensional framework. The model uncovers the parameters of variation in media Arabic and explores underlying co-occurring functions. In documenting MSA textual similarities and differences among ten written media subgenres: Politics, Economics, Society, Sports, Science, Culture & Arts, Technology, Women, Health & Medicine, and Religion, Exploratory Factor Analysis was run and resolved within a six-factorial structure, the raw output to be subsequently interpreted as six-dimensional basis for the variable use of Arabic across the ten subgenres.
Early Childhood Educators’ Views, Sentiments, Attitudes, Concerns and Practices Related to Students with Special Needs
Authors: ALICI Şule , KELEŞ Melek
Published: October 2023

This research aims to investigate early childhood educators’ sentiments, attitudes, and concerns towards students with special needs, their efficacy related to inclusive education practices, and how they follow students with special needs in their classrooms. This study uses a convergent/parallel mixed methods research design, including quantitative and qualitative research designs. The sample size of the quantitative part of the study is 135 early childhood educators. The participants for the qualitative part are ten early childhood teachers working with special needs children. The quantitative part of the study uses the scales of sentiments, attitudes, and concerns related to inclusive education and teacher efficacy during inclusive education practices. For the qualitative part of the study, researchers developed interview questions to collect data related to inclusive practices in early childhood education. The quantitative data is analyzed using the Kruskal-Wallis, Mann-Whitney, and Spearman’s rho correlation non-parametric tests. The qualitative data is analyzed with content analysis and open coding. Based on the findings, there is no relationship between sentiments, attitudes, and concerns related to inclusive education and teachers’ efficacy during inclusive education practices. On the other hand, it is found that there is a weak correlation between the dimensions of sentiments attitudes and concerns and teachers’ efficacy and its dimensions. In light of the findings derived from qualitative data, teachers feel less unsatisfied about firstly children with special needs and their parents, then themselves, and finally, typically developed children and their parents during the adaptation process.
Determining the Needs for Classroom Management Course in Associate Degree Child Development Departments
Authors: AKKAYA Tuğba , KARAKUYU Akın
Published: October 2023

The aim of this study is to determine the needs for the classroom management course in associate degree child development departments. The research was conducted using the case study method. In this context, 5 experts were included in the study group using criteriyinon sampling technique, and 201 students were included using appropriate sampling technique. Data were collected through a semi-structured interview form developed by the researchers and the classroom management competency scale. Additionally, studies conducted nationally and internationally on the subject were also reviewed for data collection. The data were analyzed using content analysis, percentage, frequency, and mean analyses. According to the results of the research, the classroom management competencies of child development department students are at a moderate level. Experts state that since graduates mainly work in the education sector, there is a need for a classroom management course in these departments. Moreover, experts mentioned that in addition to professional knowledge such as planning, knowing classroom management strategies, knowledge of methods and techniques, using instructional technologies, and designing materials, students also need to have personal characteristics such as being open to development, friendly, empathetic, and having communication skills to succeed in their professional lives. The findings obtained from the research can be used for program development or updating studies for the classroom management course in associate degree child development departments.
The Effect of a Cultural Landscape Area on Urban Green Spaces: Case Study of Diyarbakir Fortress and Hevsel Gardens
Authors: BİÇEN Arya
Published: October 2023

The Diyarbakır Fortress and Hevsel Gardens are an example of combining cultural landscapes and urban green spaces. These types of areas preserve historical and cultural richness while meeting the green and social space needs of modern cities. The aim of this study is to reveal the impact of these two important heritages, which have cultural and historical value, on urban green spaces in the Diyarbakır Sur District. The presence of green areas in the Sur district has been determined in line with this objective. Field observations, Master Development plans, planning annotations, the “management plan”, land registry records, cadastral procedures, urban guidebooks, and digital mapping platforms were employed as methodologies. Inclusive and exclusive quantifications of the designated cultural landscape area were conducted. The study quantitatively reveals the presence of active green areas in two heritage areas intertwined with culture, nature and historical built environment. The fields of heritage and nearby environmental arrangements affect the amount of green space in the Sur district. These landscaping enhancements substantially elevated the per capita functional green space in the district, increasing it from 18.22 square meters to 37.75 square meters. Similarly, they increased the availability of parking spaces, with the per person spacedetermined as 16.64 square meters. This study thus recommends increasing the regulations in buffer zones that reflect the unity of traditional and modern elements, with sustainable approaches that are compatible with ecological balance and planned for the long term
Content Analysis of Master’s and PhD Thesis on Climate: Studies Conducted in The Field of Education in Türkiye
Authors: DEMİRBAŞ İbrahim
Published: October 2023

Through geography education, students make connections between natural phenomena, environment and behavior, and climate and climate change. Climate Science is positioned as “a sub-branch of geography classified under physical geography as a basic field of study”. Climate; It is expressed as the average condition of weather conditions such as precipitation, temperature, pressure, humidity and wind as a result of long-term observations in a place. When the literature is examined, there are many studies on climate in the field of education. These studies differ in terms of research topic, method and sample. It has been determined that there are no studies aimed at determining the direction of master’s and doctoral theses on climate in the field of education. The aim of our research is to reveal the current situation by evaluating the content of master’s and doctoral theses on climate in the field of education. Document review method was used in the research. The data were analyzed through content analysis. As documents, 73 studies, including master’s and doctoral theses on climate in the field of education in our country, were examined. According to the results obtained, it is seen that the postgraduate studies on climate in the field of education are predominantly on master’s thesis and the majority of the studies were conducted in 2022. In addition, it was seen that most of the climate theses were made at Gazi University. In the studies, climate change and global warming were mostly discussed, and it was determined that the method used was mostly descriptive scanning method. In the studies, the preferred sample group was students.
The Effect of Vincent Van Gogh's Psychopathology on His Works
Authors: HALLAÇ Umut
Published: October 2023

Vincent van Gogh, whose life was summed up in the phrase "Sorrow will last forever", opened the door to a new era and led his successors to question art in a process that evolved from the abstract to the concrete, from style to substance, from nationality to universality. The artist, who personally considered himself a failure, did not stop working, despite his increasing pathological disorders, and became a great beacon of hope for the painters who would be his successors. Many competing claims have been made about Vincent van Gogh's physical and mental health, but no consensus has yet been reached. After his death, in addition to the old diagnoses, discussions inspired by his writings and letters continued about depression, bipolar disorder, borderline personality disorder, paranoid schizophrenia, schizoaffective disorder, sunstroke, self-harm, anxiety disorder, etc. Vincent van Gogh's rejection of Impressionist art, his refusal to submit to the artistic authority of the time, his disregard for academic rules and his declaration of his own manifesto on art in France, the cradle of art, are either an expression of the artist's spirit or a reflection of his pathological condition. In the context of many conflicting claims about Vincent van Gogh's physical and mental health, this study proposes an alternative interpretation of his work. It concludes that an interdisciplinary study of Vincent van Gogh's work is important for understanding him and making sense of his work.
Kandidiasis Vulvovaginal
Authors: Devi Maria , Ismunandar Helmi , Hadibrata Exsa , Djausal Anisa Nuraisa
Published: October 2023

Kandidiasis vulvovaginal merupakan peradangan yang mempengaruhi bagian dari genitalia, yaitu vulva dan vagina. Penyakit ini disebabkan oleh infeksi jamur Candida sp. terutama Candida albicans dengan transmisi karena adanya kontak langsung maupun vomit. Kasus kandidiasis vulvovaginal ini biasanya akan dialami oleh 75-80% wanita usia produktif setidaknya satu kali selama hidupnya dan sekitar 40-50% kasus kandidiasis vulvovaginal akan mengalami kekambuhan kembali. Tanda-tanda dari kandidiasis vulvovaginal adalah adanya cairan putih kekuningan berbentuk gumpalan (cottage cheese-like) dengan adanya sensasi rasa terbakar, nyeri saat berkemih, nyeri saat berhubungan seksual (dyspareunia), dan gatal disertai kemerahan pada vulva dan vagina. Penegakan diagnosis dari kandidiasis vulvovaginal terdiri dari anamnesis, pemeriksaan fisik, dan pemeriksaan penunjang laboratorium yang terdiri dari pemeriksaan langsung dengan larutan KOH 10%, pemeriksaan pH sekret vagina, pemeriksaan kultur dengan agar Saboraud, dan pemeriksaan PCR. Diagnosis dapat ditegakkan berdasarkan gejala dan tanda klinis serta ditemukannya Candida sp. pada pemeriksaan penunjang. Penatalaksanaan dari kandidiasis vulvovaginal tergantung dari spesies penyebabnya, lokasi infeksi, penyakit yang mendasari, status imunitas pasien, dan sensitifitas terhadap obat antifungal. Pengobatan pertama dari kandidiasis vulvovaginal adalah mengupayakan untuk menghindari dan menghilangkan predisposisi dan faktor pencetus. Pengobatan yang dapat diberikan adalah pengobatan secara topikal, oral, intravaginal, dan sistemik. Artikel ini akan membahas informasi mengenai etiologi, patofisiologi, penegakan diagnosis, serta tatalaksana yang dapat dilakukan pada kasus kandidiasis vulvovaginal.
Penatalaksanaan Asma Persisten Ringan Melalui Pendekatan Dokter Keluarga
Authors: Balqis Diah , Larasati TA.
Published: October 2023

Menurut GINA (Global Initiative for Asthma) tahun 2011, diperkirakan terdapat 300 juta orang menderita asma di seluruh dunia. Prevalensi asma terus mengalami peningkatan terutama di negara-negara berkembang akibat perubahan gaya hidup dan peningkatan polusi udara. Tingginya jumlah penderita asma saat ini dan kondisi lingkungan yang berpotensi menyebabkan jumlah kasus asma semakin bertambah di kemudian hari, menjadi masalah kesehatan yang serius. Peran edukasi untuk meningkatkan kesadaran masyarakat terhadap penyakit asma sangat penting untuk mencegah individu dengan predisposisi asma berkembang menjadi asma dan mencegah pasien asma mengalami serangan asma. Seorang wanita usia 52 tahun mengalami serangan asma. Diagnostik holistik pasien pada aspek personal ditemukan keluhan sesak napas semakin sering timbul dan memberat, serta khawatir tidak mampu melakukan aktivitas sehari-hari seperti sebelum sakit. Aspek klinik, pasien mengalami asma persisten ringan (ICD X:  J45.901). Aspek risiko internal pasien masih terdapat kurangnya pengetahuan. Aspek resiko eksternal pada pasien yaitu lingkungan yang cukup berdebu yang dapat mencetuskan terjadinya asma pada pasien. Dilakukan intervensi melalui farmakologis untuk serangan asma pada pasien serta non farmakologi berupa edukasi dalam mencegah terjadinya serangan asma pada pasien. Intervensi yang diberikan pada pasien telah dilakukan secara holistik dan komperhensif. Telah terdapat perubahan perilaku pasien dan keluarga yang membuat penyakit asma pada pasien menjadi lebih terkontrol.
Kriteria Diagnostik dan Pilihan Terapi Aktif melalui Medikamentosa pada pasien dengan Multipel Myeloma
Authors: Harahap Andika Ridwan Nugraha , Wintoko Risal , Oktarlina Rasmi Zakiah
Published: October 2023

Mutiple Myeloma (MM) adalah proliferasi ganas sel plasma dan sel plasmasitoid di sumsum tulang yang hampir selalu ditandai dengan adanya immunoglobulin (Ig) monoklonal atau fragmen Ig dalam serum atau urin. Multipel Myeloma menjadi keganasan hematologis paling umum kedua di negara-negara berpenghasilan tinggi. Namun, insidennya terus meningkat di seluruh dunia. Jumlah kasus yang didiagnosis setiap tahun diperkirakan hampir dua kali lipat dalam 20 tahun. Semua pasien yang dicurigai dengan diagnosis multipel myeloma harus menjalani pemeriksaan dasar karena umumnya penyakit timbul tanpa gejala. Oleh karena itu, perlu untuk mengetahui kriteria diagnosti MM agar dapat meberikan tatalaksana dengan tepat dan sesuai. Ketika pasien pertama kali didiagnosis dengan myeloma, penting untuk mengklasifikasikan dan menentukan stadium penyakit mereka secara akurat sehingga diharapkan kualitas hidup pasien dapat meningkat. Peningkatan kualitas hidup terlihat dengan adanya perawatan yang lebih baik, termasuk terapi aktif dengan obat-obatan. Tujuan pengobatan adalah untuk mengurangi beban penyakit ke tingkat yang rendah sehingga kerusakan lebih lanjut tidak dapat terjadi. Dalam beberapa decade terakhir, kortikosteroid, agen alkylating dan anthracyclines (kemoterapi standar), inhibitor proteasome, imunomodulator, penghambat histon deasetilase, antibody monoclonal, menjadi pilihan terapi berbasis medikamentossa yang sudah disetujui FDA. Jika memungkinkan, kombinasi obat yang berbeda dapat digunakan dibandingkan dengan terapi aktif lini pertama dengan satu jenis obat.
HUBUNGAN KEIKUTSERTAAN PROLANIS, KEPATUHAN MINUM OBAT DAN STATUS GIZI TERHADAP KONTROL TEKANAN DARAH PADA PASIEN HIPERTENSI DI PUSKESMAS KEDATON KOTA BANDAR LAMPUNG
Authors: Sugihen Ina Karina Putri G. , Rengganis Wardani Dyah Wulan Sumekar , Oktarlina Rasmi Zakiah , Carolia Novita
Published: October 2023

Latar Belakang: Hipertensi merupakan salah satu faktor risiko komplikasi penyakit jantung dan serebrovaskular. Angka kejadian hipertensi meningkat di dunia, termasuk Indonesia. Pada tahun 2017, prevalensi hipertensi di Provinsi Lampung mencapai 64%. Hipertensi termasuk dalam PROLANIS yang diadakan oleh BPJS Kesehatan untuk meningkatkan kualitas hidup penderitanya. Selain itu, terdapat beberapa faktor lain yang mempengaruhi tekanan darah, seperti kepatuhan konsumsi obat dan status gizi. Penelitian ini dilakukan untuk mengetahui hubungan keikutsertaan prolanis, kepatuhan minum obat dan status gizi pada pasien hipertensi di puskesmas Kedaton Kota Bandar Lampung. Metode: Desain penelitian adalah kuantitatif observasional dengan pendekatan potong lintang. Populasi penelitian yaitu pasien hipertensi di Puskesmas Kedaton, sampel sebanyak 95 responden diambil menggunakan teknik purposive sampling. Variabel bebas meliputi keikutsertaan PROLANIS, kepatuhan minum obat dan status gizi. Variabel terikat penelitian adalah kontrol tekanan darah. Data penelitian diolah menggunakan uji chi square dengan tingkat kepercayaan 0,05. Hasil: didapatkan sebanyak 78% responden memiliki tekanan darah terkontrol, 68% ikut kegiatan PROLANIS, 34% patuh mengonsumsi obat, dan 75% memiliki status gizi lebih. Uji analisis menunjukkan bahwa terdapat hubungan antara keikutsertaan PROLANIS (p:0,04) dan kepatuhan minum obat (p:0,004), dengan kontrol tekanan darah pasien hipertensi. Sedangkan, status gizi tidak memiliki hubungan yang signifikan dengan kontrol tekanan darah pasien hipertensi (p:0,602). Kesimpulan: Keikutsertaan PROLANIS dan kepatuhan minum obat berhubungan dengan kontrol tekanan darah pasien hipertensi di Puskesmas Kedaton Kota Bandar Lampung.
Penatalaksanaan Holistik Osteoarthritis dan Obese Derajat 1 Pada Wanita Usia 64 Tahun Melalui Pendekatan Dokter Keluarga
Authors: Purwati Ani , Angraini Dian Isti , Kania Susi
Published: October 2023

Osteoarthritis (OA) merupakan penyakit sendi degeneratif yang progesif ditandai dengan kerusakan tulang rawan sendi dan struktur sendi diarthrodial. Di Indonesia, OA merupakan penyakit reumatik yang paling banyak ditemui dibandingkan kasus penyakit reumatik lainnya. Penyebab OA bersifat multifaktoral, terutama meningkat pada usia 50 tahun, antara lain jenis kelamin, obese, faktor genetik dan ras, riwayat keluarga, cidera sendi, aktivitas fisik yang berat dan kebiasaan olah raga, pekerjaan, dan penggunaan sendi yang berulang-ulang. Metode yangg digunakan yaitu analisis studi. Data primer diperoleh melalui anamnesis, pemeriksaan fisik dan kunjungan rumah untuk melengkapi data keluarga, data psikososial dan lingkungan. Penilaian dilakukan berdasarkan diagnosis holistik dari awal, proses, dan akhir studi secara kuantitatif dan kualitatif. Pasien Ny P, usia 64 tahun dengan diagnosis Osteoarthritis. Pasien memiliki aspek risiko internal kurang pengetahuan tentang OA, pola berobat kuratif, pola makan yang tidak teratur. Aspek risiko eksternal pada pasien adalah kurangnya pengetahuan dan dukungan keluarga dalam pengobatan. Selanjutnya dilaksanakan penatalaksanaan secara holistik terhadap pasien dan keluarga melalui media intervensi flipchart berupa informasi tentang OA dan aktifitas yang dianjurkan untuk pasien, mengedukasi tentang latihan fisik sederhana. Dalam evaluasi ditemukan keluhan pasien berkurang, dan sudah mau mengkonsumsi makanan dengan pola hidup yang baik dan mencoba olahraga teratur. Penatalaksanaan secara holistik dapat meningkatkan pengetahuan, sikap, dan perilaku pada pasien. Selain itu, peran keluarga amat penting dalam perawatan dan pengobatan pasien serta dukungan juga diperlukan
Analisis Korelasi Jumlah Trombosit dengan Nilai Mean Platelet Volume to Platelet Count Ratio (MPR) pada Pasien Covid-19
Authors: Sangging Putu Ristyaning Ayu , Graharti Risti , Fathunnisa Ridha Riano
Published: October 2023

Penyakit Coronavirus 2019 (Covid-19) adalah penyakit infeksi yang disebabkan oleh SARS-CoV-2. Jumlah kasus Covid-19 di Indonesia hingga November 2022 mencapai 6,7 juta kasus konfirmasi Covid-19 dan 160 ribu diantaranya meninggal dunia. Dalam menangani pasien Covid-19 secara cepat dan akurat serta menurunkan angka kematian akibat Covid-19, diperlukan biomarker untuk memprediksi angka kematian pasien. Trombosit, Mean Platelet Volume (MPV), dan Mean Platelet Volume-To-Platelet Ratio (MPR) telah dipelajari secara ekstensif dan diduga dapat digunakan sebagai prediktor keparahan pasien Covid-19. Desain penelitian ini yaitu penelitian analitik observasional dengan pendekatan cross sectional yang dilakukan pada 60 pasien terkonfirmasi Covid-19 periode Januari-Desember 2021 di RSUD Bandar Negara Husada. Berdasarkan analisis statistik yang dilakukan didapatkan rerata jumlah trombosit 260,5 dan nilai MPR 0,04, serta hasil analisis korelasi bivariat Pearson didapatkan nilai r=0,850 dan p=0,005. Hal tersebut menunjukkan bahwa ada hubungan antara jumlah trombosit dengan MPR sebagai prediktor mortalitas dan terdapat perbedaan antara jumlah trombosit dengan nilai MPR pada pasien Covid-19.
HOLISTIC MANAGEMENT OF 63 YEARS OLD GERIATRIC MAN WITH AXIAL NECK PAIN THROUGH THE FAMILY MEDICINE APPROACH
Authors: Nafisah Hana , Asifa Clara Firhan , Angraini Dian Isti
Published: October 2023

The most common health problem at work is Musculoskeletal Disorders (MSDs). One of the most common complaints of MSDs is pain in the neck muscles or axial neck pain. Axial neck pain is often exacerbated and has many risk factors, especially related to workplace ergonomics. Comprehensive management is needed so that risk factors can be identified, and holistic management can be given. Application of evidence-based medicine-based family doctor services by identifying risk factors, clinical problems, and patient management based on a patient problem-solving framework using a patient-centered and family approach. Primary data were obtained through anamnesis, physical examination, supporting examinations and home visits to assess the physical environment. The patient complains of pain in the back of the neck accompanied by a feeling of stiffness in the neck. Complaints felt since 1 week ago. The pain is felt like squeezing, comes and goes, decreases slightly when you apply warm oil and rest, but a few moments later the pain will recur, the pain gets worse after working lifting heavy weights on your shoulders or turning your neck to the right and left and lowering your head. Pain also radiates from the back of the neck to the shoulders, shoulder blades and upper back. Pain does not radiate down the arm. According to the patient's statement, the pain scale felt by the patient between 1-10 is 7. Diagnosis and management of this patient is carried out holistically and comprehensively, patient center, family appropriate, community oriented with drug administration, carrying out ergonomic guidelines at work and doing cervical exercises regularly according to the EBM so that it can prevent recurrence of axial neck pain.
Sindrom MELAS: Kelainan Genetik Mitokondria
Authors: Zain Muhamad Fathurrahman , Purba Kevin Jeremia , Nabila Delisa Mutiara , Asyifa Takhfa Nur , Himayani Rani
Published: October 2023

Mitochondrial Encephalomyopathy, Lactic Acidosis and Stroke-Like Episodes (MELAS) adalah kelainan genetik bawaan mitokondria. Mitokondria paternal hanya ada di tailpiece sperma akibat mutasi pada tRNA pada gen mitokondria MTTL1. MELAS merupakan penyakit mitokondria yang paling umum dengan prevalensi kejadian 1 dari 4000. Sindrom MELAS adalah penyakit multi-organ dengan manifestasi yang luas termasuk stroke-likes episodes, demensia, epilepsi, laktat asidosis, miopati, sakit kepala berulang, gangguan pendengaran, diabetes, dan perawakan pendek. Individu dengan sindrom MELAS sering hadir dengan lebih dari satu manifestasi klinis awal. Penegakkan Diagnosis dapat ditegakkan apabila terdapat minimal dua dari kriteria berikut: perkembangan psikomotor awal normal, nyeri kepala berulang, dan episode muntah rekuren. Penatalaksanaan untuk sindrom MELAS tidak ada yang khusus namun Sebagian besar untuk tatalaksana MELAS bersifat simtomatik dan melibatkan multidisiplin seperti ahli saraf, ahli jantung, ahli endokrin, ahli audiologi, dokter mata, terapi fisik dan okupasi dan psikologi mengingat sindrom MELAS ini dapat menyebabkan disfungsi dari beberapa organ.
Enzymes of microorganisms. Proteases of lactic acid bacterias
Authors: Anuarbekova S. S.
Published: October 2023

The work is devoted to the enzymes of microorganisms. This review article presents the characteristics of microbial enzymes, their classifications according to various parameters. The study examines the role of microbial enzymes in various areas of human life. Enzymes are involved in the biochemical processes of microorganisms for their protection, reproduction, and growth. Enzyme producers are various taxonomic groups of bacteria, filamentous fungi, actinomycetes and yeasts. The article describes hydrolytic enzymes, reveals the importance of the protease enzyme involved in various processes with microorganisms. The main producers of proteolytic enzymes are bacteria of the genus Bacillus, Lactobacillus, Streptococcus, Micrococcus, Pseudomonas, fungi of the genus Aspergillus, Penicillium, Blakeslea, actynomicetes of the genus Streptomyces, Actinomyces. Particular attention is paid to lactic acid bacteria. The significance of the use of protease in the biotechnological industry, in particular, for the development of preparations, starter cultures, bioadditives, and functional food products with desired properties, is shown. The article mentions the results of a study of the proteolytic activity of cultures of microorganisms, obtained by me and my colleagues. The objects of study were bacilli, yeast, fungi and lactic acid bacteria.To assess proteolytic activity, in vitro methods, chromatographic and other methods are used.
Hybrid information systems modeling technology for business process analysis based on the internet of things
Authors: Askaruly B. , Abitova G. A.
Published: October 2023

This article examines the impact of Internet of Things (IoT) data integration and hybrid information systems modeling on business process analysis. The study aims to confirm the assumption that such integration increases the accuracy and efficiency of the analysis.

The review part emphasizes the importance of analyzing business processes for successful existence in a rapidly changing and competitive business environment. The main focus is on the use of IoT and modeling of information systems to improve the productivity of the organization.

The methodological part describes the research approach: collection and analysis of empirical data in comparison with scientific literature. The integration of real-time IoT data with information systems modeling is the basis of the research approach.

The results of the work confirm the initial assumption, revealing the significant impact of the integration of IoT data and modeling of information systems on the analysis of business processes. This allows organizations to achieve greater operational efficiency, optimize resources and make informed decisions.

The practical value of the hybrid approach is emphasized for organizations wishing to improve the analysis of their business processes. Integration of IoT and modeling of information systems helps to optimize processes and increase overall productivity.

The work confirms the importance and usefulness of using a hybrid approach in the analysis of business processes based on IoT, highlighting the advantages of integrating IoT data and modeling information systems. The hybrid approach has the potential to improve business processes and achieve success in today's competitive environment.
Assessment of the spatial distribution of low-temperature plasma parameters on plasma-beam installation
Authors: Kaiyrbekova A. , Miniyazov A. , Tulenbergenov T. , Zhanbolatova G. , Stepanova O.
Published: October 2023

At present continue, studies of the interaction of plasma with structural materials of the first wall and divertor of the ITER international experimental fusion reactor on operating tokamaks and simulated plasma facilities. In the research of the interaction of plasma with the surface of candidate materials TNR an important role plasma parameters play. For determination of local values of the main plasma parameters there is a separate field of research – plasma diagnostics. Plasma diagnostics is the determination of local and instantaneous values of main its parameters: concentration and temperature of charged plasma particles, as well as the distribution functions of various plasma components by energies.

This works presents the results of a research to the spatial distribution of local parameters (temperature electrons (Te) and plasma concentration (ne)) of a low-temperature plasma on a plasma-beam installation (PBI) with the help a movable Langmuir probe with the following geometrical parameters of the electrode: length – 4 mm; diameter 0.5 mm. The probe sweep was with the help a Keithley 6487 picoammeter. The processing of volt-ampere characteristics (VAC) was carried out by standard methods.

To assess the spatial distribution of the above-mentioned parameters of low-temperature plasma, experiments were carried out with the location of the probe at a distance of 5 mm, 9 mm and 11 mm from the center of the plasma beam at different energies of the primary electron beam in the range from 0.5 keV to 5 keV.

The experiments results showed a smooth decrease in plasma concentration in the radial direction.
Could tractography help in the diagnosis of motor neuron diseases\amyotrophic lateral sclerosis? A case report
Authors: Castro Felicio Felipe de , de Brito Campos Marcello , Orsini Neves Marco Antônio , Antunes Pereira Daniel , Brandão Toomassini Lara Alexandre , da Silva Catharino Antonio Marcos
Published: October 2023

Introduction: Amyotrophic lateral sclerosis (ALS) is a disease that affects motor neurons, progressively degenerating them. This degeneration process has a complex and multifactorial etiology, culminating in the motor disability of the carriers.

Case Report: The case report discusses a clinical suspicion of motor neuron disease (ALS) in the patient NVF, male, 72 years old, with a report of falls and paresis in the left distal crural third for two years. His condition evolved with the four limbs and trunk involvement, but it does not show bulbar involvement. In addition, atrophy, fasciculations, and paresis have been identified from lower motor neuron injury in all four limbs. Regarding the pyramidal pathway, only lively but symmetrical reflexes.

Conclusion: In the last two decades, there have been significant advances in non-invasive imaging techniques, which allow the evaluation of brain structure, as is the case with tractography. Although this technique does not diagnose ALS, it can help early detection.
Lumbo-renal arteriovenous fistula: An unusual complication of percutaneous kidney biopsy
Authors: Mahesh Prasad Khairwar
Published: October 2023

Arteriovenous fistula formation after percutaneous kidney biopsy is not uncommon. Most of these fistulas are intrarenal and close spontaneously. Formation of a fistula between an intercostal branch of the lumbar artery and the renal vein is a very rare complication. Our case has lumbo-renal arteriovenous fistula (AVF) following a percutaneous kidney biopsy. The AVF was successfully treated with embolization. Post-biopsy observations should include Doppler surveillance in order to detect such rare but potentially catastrophic complications.
Cumhurbaşkanı Celal Bayar’ın Kızı Milletvekili Nilüfer (Bayar) Gürsoy’un TBMM'deki Faaliyetleri
Authors: ÇİNİ ŞİMŞEK Derya
Published: October 2023

Üçüncü Cumhurbaşkanı Celal Bayar’ın kızı olan Nilüfer (Bayar) Gürsoy, Millî Mücadele döneminde dünyaya geldi. Atatürk Dönemi, İsmet İnönü Dönemi, Demokrat Parti Dönemi ile 27 Mayıs 1960 ve 12 Eylül 1980 Darbeleri gibi Cumhuriyet tarihinin önemli dönemlerine tanıklık eden Gürsoy, 27 Mayıs 1960 darbesinin doğurduğu siyasal ve toplumsal koşullar sonucu aktif siyasete girdi. Adalet Partisi ve Demokratik Parti’de milletvekilli olarak görev alan Gürsoy, 1965-1980 yılları arasındaki siyasal yaşamı süresince; XIII. Dönem Adalet Partisi Bursa Milletvekili, XV. Dönem Demokratik Parti İstanbul Milletvekili ve XVI. Dönem Adalet Partisi İstanbul Milletvekili olarak TBMM’de görev yaptı. Nilüfer (Bayar) Gürsoy’un milletvekilliği dönemi meclisteki faaliyetlerini açık ve objektif bir durumda ortaya koyarak Türk siyasi yaşamının anlaşılmasına katkı sağlamayı amaçlayan çalışma, literatür taraması yapılarak Gürsoy 'un milletvekili olarak TBMM’de görev yaptığı XIII, XV ve XVI. Dönemlerde meclise sunduğu kanun teklifleri ve önergeleri, konuşmaları ile sınırlandırıldı. Çalışmada; TBMM zabıtları ve TBMM Arşivi'nden yararlanılmış, dönemin gazeteleri çalışmaya önemli katkı sağlamıştır.
Türkiye’de Enerjinin Yerelde Gelişiminden Bir Kesit: Urfa’da Elektrik (1929-1971)
Authors: TANIK İbrahim Halil , DAĞ Mustafa
Published: October 2023

19. yüzyılın sonlarından itibaren Avrupa ülkelerinde kullanımı hızla artış gösteren elektrik aynı yüzyıl içerisinde Osmanlı İmparatorluğu’nda da kullanılmaya başlanmıştır. İmparatorluk genelinde elektrik ilk olarak, Osmanlı donanmasında, sinema alanında telgraf ve postaların ulaşımında ve sağlık ile tıbbi teçhizat alanında kullanılmıştır. 20. yüzyıla gelindiğinde ise elektriğin kullanım alanı oldukça yayılmıştır. Bu yayılışa bağlı olarak pek çok insan elektrikten faydalanma girişiminde bulunmuştur. Bu girişimler daha çok elektrik makinaları ile aydınlatma şeklinde gerçekleşmiştir. Nitekim imparatorluk bu talebe karşılık kayıtsız kalmayarak elektriği kamu hizmeti olarak halkın kullanımına sunmuştur. Böylece elektriğin son kullanım alanı kamu hizmeti olarak gerçekleşmiştir. Bu hizmet ise imparatorluğun son yıllarında olduğu gibi ilk yıllarında da özel girişimciler aracılığı ile hayata geçirilmiştir. Cumhuriyet döneminde kurumları millileştirme politikası çerçevesinde yerli sermayenin denetimi altına alınan elektriğin bir örneği de Urfa kentinde gerçekleşmiştir. Bu bağlamda Urfa kentinde elektrik ile ilgili her türlü gelişmenin değerlendirildiği bu çalışmada Devlet Arşivleri, yerel basın arşivi ile araştırma ve inceleme eserlerden istifade edilmiştir.