bluuebunny/crossref_metadata_2025 huggingface dataset:
BRAINWASHING SCHEMES AMONG ADOLESCENTS WITH RADICAL POTENTIAL THROUGH STUDENT ORGANIZATIONS IN HIGHER EDUCATION INSTITUTIONS
Authors: Kurniawan Wahyu
Published: August 2024

This study aims to examine the psychological aspects of brainwashing schemes among adolescents with radical potential within student organizations at University X. Adolescence is a period of contradictions, where psychological stability is often fragile, and emotions can be difficult to control. This instability can lead to behaviors that undermine national unity, as evidenced by the growing tendency of youth toward religious radicalism. According to data from Babel Review (2019), based on a 2017 survey by the National Counterterrorism Agency (BNPT), the Bangka Belitung Islands Province ranks fifth nationally in radicalism potential within educational settings. The rise of religious radicalism is often rooted in fragmented religious understanding, misinterpretation of religious texts, and political and economic deprivation, as noted by Azyumardi Azra. This study employs a qualitative methodology to explore the internal cadre training processes within radical organizations, particularly focusing on the brainwashing techniques used in recruiting new members. The findings reveal that these brainwashing practices are systematically and structurally implemented within such organizations, posing a serious threat to social harmony and national unity. This research contributes to a deeper understanding of the radicalization process among adolescents and provides insights into more effective preventive strategies through educational and psychological interventions.
Effect of Microwave Curing on the Performance of High-volume Fly Ash Concrete
Authors: Lam Tri-Khang , Nguyen Dinh-Thang , Le Tri Ho Minh , Huynh Trong-Phuoc
Published: August 2024

Concrete curing significantly impacts mechanical properties and durability, yet traditional methods face efficiency challenges. Microwave curing (MC) offers a promising alternative, providing rapid and uniform concrete curing. However, fully understanding the impact of MC on concrete performance, particularly in high-volume fly ash concrete (HVFC), remains a research gap. This study addresses this gap by investigating the effect of MC on key properties of HVFC, including compressive strength, drying shrinkage, chloride ion penetration, and resistance to sulfate attack. Concrete specimens underwent MC at varied energies (200–1000 W) and durations (10–30 min) to evaluate their mechanical and durability characteristics. Results show that MC significantly boosts early-stage concrete strength, notably at high applied energy. The specimen cured at 1000 W for 30 min (MC1000-30) achieved the highest 1-day strength of 23.68 MPa. However, the normal curing specimen exhibited the highest strength of 32.07 MPa at 28 days while the strength value of the MC1000-30 specimen declined to 20.25 MPa, indicating a 36.85% decrease. Although declining strength was observed after 28 days, the MC1000-30 specimen demonstrated improved durability with significantly reduced drying shrinkage (by 83.12%) and chloride ion penetration (by 31.6%). The study underscores the feasibility of utilizing MC for HVFC as it demonstrated significant enhancements in both early-stage concrete strength and durability at a later stage. Careful parameter optimization can ensure sustained effectiveness over time, offering a viable alternative to traditional curing methods.
PENJAMINAN MUTU PERGURUAN TINGGI DI ERA DISRUPSI PENDIDIKAN TINGGI MELALUI DIGITALISASI AKREDITASI
Authors: Nugroho Kandung Sapto
Published: August 2024

This article is a conceptual study to ensure higher education quality through higher education accreditation at the level of study programs and higher education institutions while there is disruption in the field of education. The purpose of this study is to find out the urgency of quality assurance by identifying challenges to develop a quality assurance strategy. The method used in this conceptual study is a juridical study of applicable laws and regulations (positive law) in the higher education system in Indonesia combined with a systematic literature review on related references. The results of the study show that disruption in the education system will continue towards a new establishment. Digitization of accreditation services needs to be carried out due to changes in user characteristics and the challenges of the rapid development of information technology. The quality assurance strategy through accreditation can be carried out by integrating several information systems and databases, then replicating SISTER into a measurable and transparent accreditation service system, increasing digital skill competencies, and encouraging collaboration to accelerate the establishment of Independent Accreditation Institutions so that it requires strengthening at the policy, managerial, and operations to create effective, efficient, equal and equity services.Artikel ini merupakan kajian konseptual dalam upaya penjaminan mutu perguruan tinggi melalui akreditasi perguruan tinggi pada tingkat program studi dan institusi perguruan tinggi di saat bersamaan terjadi disrupsi di bidang pendidikan. Tujuan kajian ini adalah untuk mengetahui urgensi penjaminan mutu dengan mengidentifikasi tantangan untuk menyusun strategi penjaminan mutu. Metode yang digunakan dalam kajian konseptual ini adalah kajian yuridis peraturan perundang-undangan yang berlaku (hukum positif) dalam sistem pendidikan tinggi di Indonesia dengan dipadukan dengan systematic literatur review pada referensi yang terkait. Hasil kajian menunjukkan bahwa disrupsi di bidang sistem pendidikan masih akan terus berlangsung menuju kemapanan baru. Digitalisasi pelayanan akreditasi perlu untuk dilakukan karena perubahan karakteristik user dan tantangan perkembangan teknologi informasi yang sangat cepat. Strategi penjaminan mutu melalui akreditasi bisa dilakukan dengan mengintegrasikan beberapa sistem informasi dan pangkalan data, kemudian mereplikasi SISTER menjadi sistem layanan akreditasi yang terukur dan transparan, peningkatan kompetensi digital skill, dan mendorong kerjasama percepatan pendirian Lembaga Akreditasi Mandiri sehingga membutuhkan penguatan pada level kebijakan, manajerial, dan operasional untuk menciptakan layanan yang efektif, efisien, equal, dan equity.
Intralesional Triamcinolone Acetonide Injection as a Treatment for Granulomatous Tissue on Tracheocutaneous Stoma
Authors: Kim Min Woo , Jin Myung Ho , Kim Jong Kwan , Chang Dong Sik
Published: August 2024

Background and Objectives The aim of this study was to confirm the effect of intralesional triamcinolone acetonide injections (TRIAM) to treat granulomatous tissue surrounding the tracheostomy stoma.Subjects and Method We reviewed and documented the medical charts of 20 patients who were administered with TRIAM to treat granulomatous tissue surrounding the tracheostomy stoma from January 2018 to June 2019 were. The surface area of the granulomatous tissue was measured using Image J. The differences between the area of the granulomatous tissue after conventional treatment and after TRIAM on the same patient were compared.Results A total of 20 patients consisting of 12 males and 8 females were included, with the patients’ average age being 60.0±14.3 years. The initial surface area of granulation tissue was 1.266±0.449 cm2, and 1.243±0.432 cm2 after conventional treatment, showing no statistically significant difference in the tissue area (p=0.143). The pre-injection surface area of granulation tissue was 1.243±0.432 cm2, and the area on the 7th day after the third injection was 0.477±0.217 cm2, showing a significant difference (p<0.001).Conclusion Compared to the conventional treatment, the surface area of granulomatous tissue surrounding the tracheostomy stoma significantly decreased after being treating with TRIAM. This finding suggests the effectiveness of TRIAM as a treatment of granulomatous tissue surrounding the tracheostomy stoma without complications such as bleeding.
A Case of Remission of Refractory Eosinophilic Otitis Media Treated With Dupilumab
Authors: Choi Hyunseok , Kim Dongha , Chae Sung Won , Song Jae Jun
Published: August 2024

Eosinophilic otitis media is characterized by highly viscous middle ear effusion and associated with bronchial asthma and chronic rhinosinusitis with nasal polyps. It is difficult to treat with conventional therapy such as corticosteroid and ventilation tube insertion. We have encountered a 58-year-old patient with refractory eosinophilic otitis media who was successfully treated with dupilumab.
Synovial fluid analysis in healthy green turtles Chelonia mydas in Taiwan
Authors: Su HP , Chi CH , Li TH , Cheng IJ , Yu PH
Published: August 2024

Septic arthritis is a frustrating disease in sea turtle rehabilitation because of its unclear pathogenesis, delayed onset during rehabilitation, long-term treatment requirements, and potentially poor prognosis. Radiography, blood cultures, and arthrocentesis have been used as diagnostic tools for suspected cases. However, there is currently a lack of data on the characteristics of synovial fluid in healthy sea turtles. To establish reference data for synovial fluid in sea turtles, we enrolled 14 green turtles Chelonia mydas rescued between 2019 and 2022 from 3 facilities using the following inclusion criteria: normal attitude and appetite, normal motor functions of the 4 limbs, no joint swelling, and no ongoing use of antibiotics for at least 1 mo. Bacterial cultures of blood and synovial fluid from the shoulder joints of these turtles were obtained and a qualitative analysis of the synovial fluid was performed. The results revealed bacterial culture-negative blood and synovial fluids at 37°C. Most characteristics of normal synovial fluid in green turtles, such as being transparent, colorless, and able to create a strand of over 2.5 cm by being pulled with a needle in viscosity trials, as well as the cytology of the normal synovial fluids being dominated by histiocytes and synovial lining cells, lymphocytes, and occasionally a few heterophils or erythrocytes were similar to those in mammals. This study provides information on the normal synovial fluid characteristics of green turtles in Taiwan, which may be beneficial for the diagnosis of joint diseases in sea turtles.
Inactivation in vitro of the marine parasite Amyloodinium ocellatum
Authors: Sousa R , Laizé V , Lourenço-Marques C , Barata M , Pousão-Ferreira P , Soares F
Published: August 2024

The ectoparasite Amyloodinium ocellatum is a dinoflagellate that causes severe morbidity and mortality in both brackish and marine warmwater aquaculture fishes worldwide. A. ocellatum has a triphasic life cycle based on a free-living flagellate (the dinospore), a parasitic stage (the trophont) and a resting and reproductive cyst (the tomont). Current chemical treatments have shown some efficacy in eliminating dinospores but fail to inactivate the tomonts. Here we evaluated the efficacy of alternative treatments in vitro through sporulation tests and the quantification of dinospore production and motility. Hydrogen peroxide and peracetic acid efficiently decreased dinospore production at low concentrations, but total inactivation of tomonts was only achieved with higher dosages. Tomont inactivation was also observed with disinfectants such as sodium hypochlorite and Virkon S. This work provides insights into effective and environmentally friendly alternatives for the elimination of resistant forms of the marine parasite A. ocellatum.
Ferdinand Uličný a jeho pôsobenie v Štátnom archíve v Prešove
Authors: Mišíková Alena
Published: August 2024

Prof. PhDr. Ferdinand Uličný, DrSc. served as the director of the State Archive in Prešov from 1958 to 1961. In his capacity as the head of the team, he compiled the Guide to the State Archive in Prešov. He primarily processed medieval and early modern documents to ensure their accessibility to researchers and the public. For this purpose, he prepared inventories of several archival funds, including The House of Druget (Drugeth) from Humenné and The House of Uz (Usz) from Uzovce. In 1972, F. Uličný returned to the State Archive in Prešov as a professional archivist and researcher after being forced by the socialist state government to leave the university. Subsequently, he made other archival documents available in the form of catalogues, such as The House of Farkas from Záborské and the oldest books and congregational minutes of the Šariš County. In 1979, F. Uličný was awarded The Pavel Križko Medal for his contribution to the development of Slovak archivistics. Additionally, he devoted himself to scientific and publishing activities. From 1987 to 1988 he served as the deputy head of the archive, where he worked until 1990, when he returned to the university after the fall of the socialist regime.
Ferdinand Uličný a výučba archívnictva v Prešove (UPJŠ/PU v Prešove 1990 – 2003)
Authors:   University of Prešov, Domenová Marcela
Published: August 2024

Ferdinand Uličný and Teaching of Archival Sciences in Prešov (UPJŠ/PU in Prešov 1990 – 2003) The paper presents the personality of the university teacher, archivist and historian Ferdinand Uličný (born in 1933), who spent a significant part of his professional life in Prešov. While working at the university, he taught the Slovak history in the Middle Ages, archival studies, and auxiliary historical sciences. In Prešov, he founded and also guaranteed a university course in archival studies at the Faculty of Arts in Prešov (1991). He was the head of the Department of History and Archival Studies at the Faculty of Arts in Prešov, Pavol Jozef Šafárik Univesity in Košice (1997 – 1998), and later of the Department of Slovak History and Archival Studies at the Faculty of Arts, University of Prešov (1998 – 2003). The paper also discusses other members of the department, the forms of the study field of archival studies, curriculum (study plans), and the profile of the graduates.
Cesta historika v dobe neslobody. K pôsobeniu Ferdinanda Uličného vo Východoslovenskej pobočke SHS v Košiciach
Authors: Balvirčáková Miriama
Published: August 2024

The Historian‘s Journey in the Period of Totalitarianism. On the Work of Ferdinand Uličný in The Eastern Slovak Branch of the Slovak Historical Society in Košice The aim of the paper is a brief analysis of the professional life of the historian Ferdinand Uličný within his work at the East Slovak branch of the Slovak Historical Society at the Slovak Academy of Sciences, which played a significant role in scientific historical research in eastern Slovakia. The article presents basic information about the establishment and activities of the branch in Košice in chronological order, taking into account F. Uličný´s professional activities. It also traces his professional growth and successes in managing the branch, as well as the setbacks caused by political changes and the influence of the communist government in the 1960s and 1970s. Despite adverse events in the professional field, F. Uličný continued his scientific work as an archivist and historian. The article concludes by focusing on significant changes in the country after 1989, considering the activity and future of the East Slovak branch and the Slovak Historical Society.
Výskum dejín miest na Slovensku po roku 1989
Authors: Pekár Martin
Published: August 2024

Research on the History of Cities in Slovakia After 1989 This article examines the nature of research on the history of cities and towns in Slovakia after 1989, focusing on the role of Ferdinand Uličný in this field. It highlights the significance of urban history in Slovak historiography, acknowledging variations in the quality and typology of the comprehensive works. Historian Ferdinand Uličný conducted research in this area, leveraging extensive knowledge of primary sources, the history of the Hungarian Kingdom, and a multidisciplinary approach. His work is grounded in local and micro-historical contexts. Interpretively, Ferdinand Uličný made significant contributions to the understanding of the crucial role of towns in the social development of medieval Hungary, particularly in the region of contemporary Slovakia.
Implementation of Problem-Based Learning (PBL) Model to Improve Students’ Learning Outcomes in Two-Dimensional Geometric Shapes Material
Authors: Tawassalna Fadhila , Hasnita
Published: August 2024

This study aims to improve the process and mathematics learning outcomes for class VIII students. 7 SMP Negeri 34 Pekanbaru through applying the Problem-Based Learning model. The subjects of this study were students of class VIII. 7 SMP Negeri 34 Pekanbaru, a total of 39 students consisting of 21 male and 18 female students. This is a classroom action research (CAR) consisting of 2 cycles. The data collection instrument consists of an observation sheet and a learning outcome test sheet that has been analyzed. Furthermore, the data analysis technique used is descriptive data analysis in the form of qualitative and quantitative data analysis. The observation sheet at each meeting shows an improvement in the process, and based on learning outcomes, there is an increase in learning, as seen from the number of students who reached the KKTP and the average student learning outcomes in mathematics. So, it can be concluded that applying the Problem-based Learning model can improve the process and mathematics learning outcomes for students in class VIII. 7 SMP Negeri 34 Pekanbaru.
Analysis Error Student in Solving Problem Logarithm Based on the Kastolan Procedure
Authors: Bestari Aulia Merlin , Rani Ayu Nanda Mustika , Gusmarini
Published: August 2024

Mathematics is very important in teaching students to have and apply mathematical thinking patterns in everyday life and become a reference for studying various other branches of science. One of the mathematics materials is logarithms, where students often make mistakes when solving these problems, so it can indicate how far students have mastered the logarithm material chosen for this research because logarithms have properties that students must understand. So, this research aims to analyze the errors made by students when solving logarithm problems using the Kastolan procedure. Subject in this study, nine students from class X IT SMKS, Darel Hikmah Pekanbaru. The research instrument used a 5-item logarithmic description test instrument. The data analysis techniques are data reduction, data presentation, and conclusion. Based on the research data results, it was concluded that students made conceptual errors, namely the inability to apply the concept of the properties used. Procedural errors were when students were unable to solve the problem until they got the final solution, and technical errors occurred because they made mistakes in calculations to produce answers wrong.
Analysis Error Student Class X Vocational School in Solve Story Questions on the Material System of Three Variable Linear Equations
Authors: Ijjati Salsabila Filjania , Elfita
Published: August 2024

Conducting formative assessments can help students grasp the fundamentals of the subject matter and foster a deeper interest in mathematics. To better understand student difficulties in solving word problems related to SPLTV, researchers have conducted studies to analyze the errors made. This research aims to discover and analyze students' mistakes in solving story problems on the material of three-variable linear equation systems. This type of research is descriptive research with a qualitative approach. The subjects of this research were six students from 31 students of class X TKJT 1 SMK Muhamadiyah 2 Pekanbaru, each consisting of 2 students from the upper, middle and lower groups. In this research, data collection techniques were based on observation, instrument test questions, and interviews, which were used to determine students' errors in solving three-variable linear equation systems. In this research, it can be concluded that students' mistakes are a lack of mastery of concepts in three-variable linear equation systems material and a lack of deeper student mathematics learning so that students make any mistakes in solving problems.
Implementing the Problem-Based Learning (PBL) Model to Improve Learning Outcomes in Probability in Junior High Schools
Authors: Safitri Erfira
Published: August 2024

This study examines the effectiveness of the Problem-Based Learning (PBL) model in enhancing learning outcomes on probability materials among junior high school students. Employing a classroom action research design implemented over two cycles, this study involved eighth-grade students at a public junior high school in Pekanbaru. The PBL method was applied to increase student engagement in learning, facilitate a deep understanding of probability materials, and develop their problem-solving skills. The findings indicate that implementing PBL successfully increased the percentage of students achieving the minimum mastery criterion (KKM) from 30% at the baseline to 65% at the end of the second cycle. This research confirms that PBL is an effective learning strategy for probability materials at the junior high school level, with positive implications for conceptual understanding, social skills, and student learning motivation. These findings suggest that the PBL approach should be more broadly applied in the school mathematics curriculum to enhance mathematics learning outcomes.
Improving Students' Mathematics Learning Outcomes Through The Application of Matrix Domino Card Media
Authors: Rohayat Ahmad , Alamsyah Trian Pamungkas
Published: August 2024

This study was motivated by the low mathematics learning outcomes of SMK Negeri 1 Bayah students. It is necessary to apply learning media that helps improve students' abilities. One of the learning media used is the Domino Matrix Card. This study aims to determine the learning outcomes of students who received treatment using matrix domino cards compared to students who were not given the treatment of learning using matrix dominoes. The results showed that the learning outcomes of students who were treated using matrix domino card media were higher than the learning outcomes of students without using matrix domino card media. The results of the statistical test showed that the learning interest of students utilising the matrix domino card media in the experimental class obtained an average = 67.78 and standard deviation = 20.88 while learning without using the matrix domino card media in the experimental class obtained the average data of students' learning interest = 49.72 and standard deviation = 15.48. After the t-test obtained the results that t count > t-table, which is 1.80> 0.354, the results of hypothesis testing obtained are t count > t-table, then Ha is accepted, meaning that there is an increase in student learning outcomes using matrix domino card learning media in class XI SMKN 1 Bayah 2019/2020 academic year.
Translating Late Byzantine Medical Texts into Latin in the Sixteenth Century: The Cases of John Zacharias Aktouarios and the Dynameron
Authors: Stathakopoulos Dionysios
Published: August 2024

This article examines two late Byzantine medical works printed in the first half of the sixteenth century: the treatises of John Zacharias Aktouarios and the Dynameron (traditionally attributed to Nicholas Myrepsos). The translations were part of a humanist initiative to return to the sources and translate all Greek medical books into Latin, displacing the existing translations from Arabic and adding new material. These Byzantine texts (before the term became current) were regarded as repositories of Greek medical knowledge and presented as significant contributions to medicine.
Fighting till his Final Breath: Richard Demarco as a Public Intellectual
Authors: Ellis Charlie
Published: August 2024

Richard Demarco has long been a prominent figure in the Scottish cultural sphere. He has been a significant cultural progenitor, raising the profile of the visual arts within Scotland. In his long cultural life he has often come into conflict with Scotland’s cultural ‘officialdom’ and is a strident critic of the present-day Edinburgh Festival and Fringe. This article examines Demarco the public intellectual, often overshadowed by Demarco the provocative, hyperbolic showman. It identifies and contextualises Demarco’s abiding themes, locating them in a belief that art has a unique ability to heal personal and societal wounds. It goes on to examine whether his ‘declinist’ dismissal of much contemporary culture stems from an elitist disdain and whether his cultural vision is nostalgic and narrow. The article also examines Demarco’s critiques of both commercialism and state-supported cultural institutions. It argues that underneath the public persona there lies a unique and challenging cultural vision; one which will survive after his rich cultural life ends.
Climate stabilizing value of oak shelterbelts in Zhytomyr Polissia
Authors: Moroz V.
Published: August 2024

Woody forest plantations, including shelterbelts, are one of the stabilizers of the optimal ecological state of the environment in agricultural landscapes. Shelterbelts are able to sequester carbon from the atmosphere in their phytomass and generate oxygen for a long time. These processes contribute to the partial but permanent prevention of global climate change. According to the calculations, we determined the volume of tree trunks in the protective strips, the cross-sectional area of the trunk, and the phytomass of wood, bark, and crown in a completely dry state. Based on the research data, correlations were created between the main taxonomic indicators and phytomass fractions, which showed a close relationship between phytomass fractions and the height and diameter of tree trunks. In the course of the research, a regression equation was built between tree phytomass and biometric indicators such as trunk height and diameter. The amount of carbon sequestered by the oak shelterbelts was determined by determining the proportion of carbon in the phytomass in absolutely dry residue. The main soil and climatic indicators were established, which in most temporary test plots were characterized by pH=7.0 (neutral), the level of atmospheric air temperature under the forest protection strips was 2°C lower than in agroecosystems (field), and the soil temperature was 8°C lower than in the studied agroecosystems. Soil moisture was identical. According to the statistical analysis, the sample was homogeneous in terms of height, diameter, and age of the plantation. The obtained results allow for further analysis and construction of regression equations between tree phytomass and biometric parameters — height, diameter. It has been determined that an increase in tree diameter by 1.94% and height by 1.0% has a direct impact on the growth of phytomass of common oak wood. It has been established that the total phytomass of oak in linear plantations is 157.7 kg for a middle-aged tree and 275.9 kg for a mature tree. According to the established value of the conversion coefficient of the carbon-absorbing capacity of field protection strips of oak plantations, CO2 emissions into the atmosphere in the Zhytomyr Polissia zone are annually reduced by 5%. The obtained equation of the conversion coefficient, with a sufficiently high determination index, makes it possible to use the obtained dependence in further calculations.
Ecological assessment of natural complexes in «Serednie Pobuzhzhia» regional landscape park: theory and practice
Authors: Mudrak O. , Mudrak H. , Antoniuk Yu. , Riabokon O. , Herasimova O.
Published: August 2024

The article proposes a methodology for determining the ecological assessment of natural complexes in «Serednie Pobuzhzhia» regional landscape park (RLP) according to psychological, aesthetic and geographical and aesthetic criteria. The representative landscapes of the park, which covers an area of 2618.2 hectares and was established in 2009, are located within Tyvriv and Sutyska settlement territorial communities of Vinnytsia region. The park was created to preserve the integrity of the unique landscapes of the valley and water area of the Pivdennyi Buh river. The park is decorated with rapids on the Pivdennyi Buh river, which were formed in places where crystalline rocks of the Ukrainian shield come to the surface, often forming cascades and stretching for up to several kilometres. Some blocks of granite rise up to 1.5 m above the water, which forms the corresponding aesthetics of the landscape. The park is home to boreal, non-morphic and pontic vegetation, represented by rare, endemic and relict species. The Pivdennyi Buh river valley is of great importance for the conservation of biotic and landscape diversity and requires protection and rational use of its resources. One of the anthropogenic impacts on the park’s natural complexes is recreational pressure. Therefore, the authors established the maximum recreational load on the natural complexes of the studied park according to the distribution of landscape types — park, forest, non-forest. On the basis of the conducted research, it is argued that in order to preserve the representative and unique biotic and landscape diversity of the park in the structure of the Buzkyi longitudinal natural corridor of the national ecological network, it is necessary to introduce a set of measures, taking into account the recreational load. In order to preserve the representative biotic and landscape diversity in the structure of the ecological and Emerald networks, it is necessary to expand the area of «Serednie Pobuzhzhia» park and include «Nemyrivske Pobuzhzhia» regional landscape park with an area of 5,678 hectares, creating a single continuous national nature park.
Agroecological and economic assessment of organic crop rotation in Polissia zone
Authors: Savchuk O. , Pryimachuk T. , Drebot O. , Kudryk A. , Tsuman N.
Published: August 2024

For the organic production of plant products on sod-podzolic soil, a biologized short-rotational grain rotation was put to study: sorghum–oats–oats– vicot–oats–barley. In conditions of shortage of manure, the optimization of the nutrition system is carried out due to the by-products of grain and leguminous crops, oil radish siderate, the use of foliar treatment of crops with preparations of biological origin (microfertilizer Avatar, biopreparation BiocomplexBTU and liquid biofertilizer Volynski humaty), including, in the background mineral fertilizers allowed in organic production (P40K60 — phosphorite flour and potassium sulfate). The goal of the task was to investigate the influence of the biological fertilization system on crop rotation productivity, grain quality, soil fertility, and the economic efficiency of crop cultivation. It was established that, on average, during the 2021–2023 research, the maximum grain yield indicators were obtained for all factors of influence: pea-oats — 2.25 t/ha, oats — 1.88, vetch-oats — 1.66 and barley — 1.61 t/ha, the total crop rotation productivity under these conditions was 2.28 t grain units. It was determined that the protein content of oat grains was 9.1–9.8%, barley — 10.8–11.7%, the protein content of flax seeds was at the level of 18.2–19.0%, vetch — 22.9–23.8%, the lowest indicators were noted in the control. It has been established that in biological crop rotation due to 50% saturation with leguminous crops against the background of straw and siderate, a deficit-free balance of humus and nutrients is achieved. Due to the by-products of crops, 175 kg of humus accumulates in the soil annually, which ensures a simple reproduction of its fertility, and the additional application of fertilizers of biological origin helps to increase the humus to 350 kg, which ensures an extended reproduction of the fertility of sod-podzolic soil. Nitrogen comes at the expense of oil radish siderate, with by-products of leguminous crops and is biologically fixed from the atmosphere. Removal of phosphorus and potassium by crops is compensated by the supply of these elements with straw and siderate. Due to the disparity of prices, the cultivation of grain crops was unprofitable under all factors of influence, the profitability of legumes was 19.6–64.4%. The level of profitability of the general crop rotation for the treatment of crops with drugs was 6.5–14.8%, and the costs incurred for the purchase and application of phosphorus-potassium fertilizers did not pay off with the growth of crop yields.
Old and new versions of the Molyneux question: A review of experimental answers
Authors: Spence Charles , Di Stefano Nicola
Published: August 2024

The ‘Molyneux problem’ is typically framed in terms of the crossmodal matching of shape information from touch to vision. Indeed, shape along with intensity have commonly been considered amodal stimulus properties/dimensions (at least by developmental researchers). However, it is important to note that what is common, if anything, to the senses differs in the two cases: It is the physical stimulus (and possibly also the associated phenomenology) that is thought to be the same in the case of crossmodal (or intermodal) shape matching between touch and vision, whereas it is the nature of the underlying neural encoding that is said to be similar in the case of crossmodal matching of auditory and visual stimulus intensity. While the first empirical data to have been published on these two forms of putatively amodal crossmodal matching appeared to suggest that they both emerge surprisingly early in the course of human development (i.e., within the first month of life), certain of these seminal findings have proved difficult to replicate. Ultimately, therefore, there is currently little convincing evidence to support the notion that such putatively innate crossmodal matching of amodal stimulus dimensions is actually different in kind from the various other crossmodal correspondences that are seemingly acquired at various points during the course of human development (typically as a result of the internalization of the crossmodal statistics of the environment). As such, there may be nothing particularly special about the type of crossmodal matching thought to underlie the ‘Molyneux problem’, and continued interest in the issue may inadvertently have helped to sustain a misguided account of the differences between different types of crossmodal correspondence.
Effect of Sappan Wood Ethanol Extract in CRP Level and Phagocytic Index Between Group of Mice Infected with S. aureus and E. coli
Authors: Rohmah Martina Kurnia , Hisbiyah A'yunil , Octivani Amellya , Anwari Farida
Published: August 2024

S.aureusand E.coli are pathogenic bacterial that cause many infectious disease in the world. Immunomodulator is needed to prepare the immune system to be able against the infection. Some parameters usually used to assess the immunomodulatory activity such as C-Reactive Protein (CRP) and phagocytic index. This study aims to investigate the difference effect of sappan1wood extract  in CRP level and phagocytic index between group mice infected with S. aureus and E. coli.  Two treatment groups of mice were prepared for S. aureus and E. coli test. Each group subjected to 7 treatments i.e. (1) Normal mice1(CMC-Na 1 %- Merck® 217277), 1(2) Negative Control (bacterial infection + CMC-Na 1 %),11(3) Positive Control (bacterial infection + Imboost force®1treatment, PT SOHO Industri Pharmasi), (4) Bacterial infection and EESW treatment 25 mg/kg BW, (5) 50 mg/kg BW, (6) 100 mg/kg BW, and (7) 200 mg/kg BW. Mice blood was taken to detect the CRP and phagocytic index after treatment. The T test showed that there was a significant difference between CRP levels (p0.05) and phagocytic index (p0.05) of S. aureus and E. coli group. EESW 200 mg/kg BW reduced CRP level to 11 mg/dL (S. aureus) and 6 mg/dL in (E. coli). EESW 200 mg/kg BW increased phagocytosis to 1.54 folds (S. aureus) and 4.62 folds (E. coli). Sappan wood ethanol extract effect to CRP level and phagocytic index1in mice group infected with E. coli is better than S. aureus1infection group.
Formulation and In-Vitro Penetration Test of Ketoprofen Patch with Addition Aloe vera Powder (Aloe vera L.) Bioenhancer
Authors: Andini Septia , Rustiani Erni , Lathifah Umi
Published: August 2024

Ketoprofen is a non-steroidal anti-inflammatory drug (NSAID) which is generally used to reduce pain and inflammation. The main obstacle in administering drugs via transdermal is the low penetration of drugs through the skin. Aloe vera contains lignin compounds which are thought to be bioenhancer. This research aims to formulate ketoprofen and aloe vera powder in form patch and compare penetration patch with and without the addition of aloe vera powder. Preparation patch 3 formulas were made with different ratios of HPMC E5 and Eudragit E100 polymers F1 (6:2), F2 (8:2), F3 (10:2). Formula 3 is the best formula with a comparison of HPMC E5 and Eudragit E 100 of 10:2. Formula 3 has a thin, dry patch and is easy to remove from the mold. F3 then remade with additions bioenhancer by 5 % and patch without additions bioenhancer. The results of the physical quality test showed that the formula with and without the addition of aloe vera as an enhancer has uniform weight, thickness, pH and folding resistance which meets the requirements for patch preparation. Franz diffusion cell result for patch preparations with the addition of aloe vera showed a better penetration value than without the addition of aloe vera with a cumulative value of 92.5815 μg/cm2 and a total flux of 260.4355 μg/cm2 hour.
Anti-Inflammation Effectiveness of Ginger (Kaemferia galanga l.) and Shallots (Allium ascalonicum l.) Extract Combination on Sprague-Dawley Male Rat
Authors: Nurmala Sara , Elfrieda Nyayu Siti Aminah Lily , Zaddana Cantika , Ali Aida Azlina
Published: August 2024

Inflammation can be caused by various stimuli which include physical injury, infection, heat and antigen antibody interactions. Ginger (Kaempferia galanga L.) and Shallots (Allium ascalonicum L.) are medicinal plants that are often used by Indonesians as an alternative to natural medicine and have been studied to have good anti-inflammatory properties because they contain quercetin. This study aims to determine the effective dose of the combination of Ginger ethanol extract and Shallots as anti-inflammatory with a smaller dose. This study was carried out using male rats in 5 treatment groups, consisting of negative control (CMC-Na 0.5 %), control positive (diclofenac Na tablets 0,1 mg/kg body weight rat), and 3 combination doses of Ginger extract: Shallots extract, dose combination I (3 mg/kg body weight Rat: 2 mg / kg body weight Rat), dose combination II (6 mg / kg body weight Rat : 1 mg/kg body weight Rat), and the dose combination III (6 mg/kg body weight Rat: 2 mg kg body weight Rat) using Carrageenan Method on Rat's Feet. The results of the anti-inflammatory activity test showed that all the dose combination treatment groups had anti-inflammatory. The dose combination III was significantly different from the negative control group and showed the most effective dose of combination. The formulated combination shows a synergistic effect between ginger and shallots as an anti-inflammatory. Average percentage (%) of edema inhibition combination III is 71,08 %.
The case for monitoring metabolic and inflammatory elevated risk groups in young people with emerging mental disorders
Authors: Shin Mirim , Crouse Jacob , Nichles Alissa , Zmicerevska Natalia , Song Christine , Park Minji , Froggatt Daniel , Janiszewski Connie , Chan Karina , Koethe Dagmar , Hamilton Blake , Carpenter Joanne , Iorfino Frank , Mckenna Sarah , Scott Elizabeth , Hickie Ian
Published: August 2024

We investigated the prevalence of elevated metabolic and inflammatory risk groups in youth seeking care for emerging mental disorders. Among 124 participants (27.3±5.9 years), we analysed fasting insulin (FI), fasting blood glucose (FBG), homeostasis model assessment of insulin resistance (HOMA2-IR), and C-reactive Protein (CRP). FI (≥10mU/L) and CRP (≥1mg/L) were used to categorise metabolic- or inflammatory-risk groups, and demographic/clinical features were compared. Inflammatory risk was common (58% [n=73] with elevated CRP), as was metabolic risk (38% [n=47] with elevated FI). Notably, 25% (n=31) had elevated HOMA2-IR, while only 7% (n=9) had abnormal FBG. Elevated-risk groups had poorer mental and physical health, and the inflammatory-risk group comprised more youth with major mood disorders. Elevated metabolic and inflammatory dysfunction is common in youth with emerging mental disorders and associated with poorer clinical features. Early detection and monitoring of these markers in early intervention mental health services is needed.
Mechanisms for controlling Dorsal nuclear levels
Authors: McGehee James , Stathopoulos Angelike
Published: August 2024

Formation of the Dorsal nuclear-cytoplasmic gradient is important for the proper establishment of gene expression patterns along the dorsal-ventral (DV) axis during embryogenesis in Drosophila melanogaster. Correct patterning of the DV axis leads to formation of the presumptive mesoderm, neurogenic ectoderm, dorsal ectoderm, and amnioserosa, which are tissues necessary for embryo viability. While Toll signaling is necessary for Dorsal gradient formation, a gradient still forms in the absence of Toll, suggesting there are additional mechanisms required to achieve correct nuclear Dorsal levels. Potential mechanisms include post-translational modification, shuttling, and nuclear spacing. Post-translational modification could affect import and export rates either directly through modification of a nuclear localization sequence or nuclear export sequence, or indirectly by affecting interactions with binding partners that alter import and export rates. Shuttling, which refers to the facilitated diffusion of Dorsal through its interaction with its cytoplasmic inhibitor Cactus, could regulate nuclear levels by delivering more Dorsal ventrally. Finally, nuclear spacing could result in higher nuclear levels by leaving fewer nuclei in the ventral domain to uptake Dorsal. This review details how each of these mechanisms may help establish Dorsal nuclear levels in the early fly embryo, which serves as a paradigm for understanding how the dynamics of graded inputs can influence patterning and target gene expression. Furthermore, careful analysis of nuclear Dorsal levels is likely to provide general insights as recent studies have suggested that the regulation of nuclear import affects the timing of gene expression at the maternal-to-zygotic transition.
Case Report: Left atrial dissection after mitral valve replacement: intraoperative management under TEE guidance
Authors: Wang Mengyan , Ji Fucheng , Zhou Jinfeng
Published: August 2024

Left atrial dissection (LatD) is a very rare complication of cardiac surgery, but it is relatively more common in mitral valve surgery. Transesophageal echocardiography (TEE) plays an important role in timely detection of LatD and accurate assessment of the condition, which are key factors in determining the patient's prognosis. There are two different treatment options for patients with or without circulatory crisis caused by dissection hematoma, namely surgical management and conservative treatment. In this report, we used TEE to quickly detect the cause and severity of LatD, which assisted the surgeon in making appropriate surgical decisions. The patient was successfully surgically treated for LatD.
Research on the influence of dynamic contact angle of mercury meniscus on the interpretation of rock pore throat radius in mercury intrusion experiments
Authors: Dai Jinyou , Pi Sha , Wu Junzhe , Zhang Yang
Published: August 2024

Addressing the lack of measurement methods for dynamic contact angles of mercury meniscus in mercury intrusion porosimetry experiments and the unclear understanding of the impact of dynamic contact angles on the interpretation of pore throat radius in rocks, a new type of closed mercury intrusion characteristic curve (O-R curve) is constructed utilizing the withdrawal curve O and the secondary injection curve R obtained from the experiments. Based on the excellent wetting and de-wetting correlation characteristics at the equal mercury saturation points on this curve, a method for measuring the dynamic contact angles of mercury meniscus (O-R loop method) is established. Taking the Chang 63 tight oil reservoir samples from the Nanliang Oilfield in the Ordos Basin of China as an example, this method is applied to investigate the dynamic contact angles of mercury meniscus in mercury intrusion porosimetry experiments and the impact on the interpretation of pore throat radius in rocks. The results indicate that the dynamic contact angles of mercury meniscus changes significantly during the experiments, which cannot be ignored. And the smaller pore throats lead to more severe deformation of mercury meniscus, resulting in higher wetting resistance coefficients and hysteresis angles. Calculations reveal that the pore throat radius interpreted using the modified Washburn equation (which adopts dynamic contact angles) are generally larger than those interpreted using the conventional Washburn equation (which adopts static contact angles), with relative errors ranging from 12.2% to 54.7%. The smaller the pore throats, the larger the relative errors. The analysis shows that the conventional Washburn equation significantly underestimates the reservoir pore throat radius due to the neglect of the dynamic contact angle, while the modified Washburn equation provides more accurate interpretation. Overall, this research provides a method for calculating the dynamic contact angle in mercury intrusion porosimetry experiments and has important reference significance for the accurate interpretation of rock pore throat radius.
Association between waist triglyceride index, body mass index, dietary inflammatory index, and triglyceride- glucose index with chronic kidney disease: the 1999-2018 cohort study from NHANES
Authors: Li Zhiyu , Xu Zongping , Xuan Chenhao , Xu Hongyang
Published: August 2024

Purpose

To compare the dietary inflammatory index (DII), triglyceride glucose index (TyG), waist triglyceride index (WTI), and body mass index (BMI) in predicting the survival of chronic kidney disease (CKD).

Methodology

Inclusion of 23,099 participants from the NHANES database who met specific criteria. Baseline was established using quartiles of DII index. The relationship between DII index, WTI index, TyG index, and BMI index with mortality rate in CKD patients was evaluated using Kaplan-Meier curves. Univariate and multivariate COX regression risk models were used to study the relationship between DII index, WTI index, and TyG index with mortality risk in CKD patients. Stratification of eGFR by age and gender was conducted to investigate the association between DII index, WTI index, and TyG index with mortality risk in CKD patients. Restricted cubic spline analysis was used to study the correlation between DII index, WTI index, and TyG index with mortality risk in CKD patients.

Results

The incidence of CKD increased with the increase of DII index, WTI index and TyG index. After multivariable adjustment, the fourth quartile of DII index, TyG index and WTI index showed the highest risk for CKD [DII: hazard ratio (HR) 1.36, 95% confidential interval (CI) (1.23–1.51); TyG: HR 1.21; 95% CI (1.07–1.37); WTI: HR 1.29; 95% CI (1.13–1.46)]. There was no difference in the risk of developing CKD between the obese group (BMI ≥24 kg/m2) and the normal weight group (P>0.05).

Conclusion

This study has identified a significant association between elevated DII index, WTI index, and TyG index with the risk of CKD. Furthermore, the DII index demonstrated superior prognostic capability in predicting CKD compared to other indicators.