bluuebunny/crossref_metadata_2025 huggingface dataset:
How to Approach Secondary Breast Reduction: International Trends and a Systematic Review of the Literature
Authors: Broer P. Niclas , Moellhoff Nicholas , Aung Thiha , Forte Antonio J. , Topka Charlotte , Richter Dirk F. , Colombo Martin , Sinno Sammy , Kehrer Andreas , Zeman Florian , Rohrich Rodney J. , Prantl Lukas , Heidekrueger Paul I.
Published: April 2021

Background

Secondary breast reduction is complex and poses significant challenges to surgeons. Complication rates exceed those of primary reduction, commonly caused by impaired vascular supply of the nipple-areolar complex (NAC). Literature on the topic is scare and provides contradicting recommendations, especially with regard to pedicle choice in cases with unknown primary reduction technique. Aim of this study was to investigate international trends and to compare findings with literature.

Methods

A large-scale web-based questionnaire on international trends in mammaplasty (mastopexy and breast reduction) was designed and distributed to over five thousand surgeons in eight geographic regions. The presented manuscript evaluated information regarding pedicle choice in secondary breast reduction and compared data to literature identified in a systematic review.

Results

The survey was completed by 1431 participants. Overall, secondary procedures were performed in less than 5% or in 5 to 10% of cases. The preferred pedicle for secondary reductions differed significantly between geographic regions (p<0.001). The majority of respondents reported to use a superior or supero-medial pedicle (34.8% and 32.2%, respectively). Residual analysis revealed a strong association between the use of an inferior pedicle and procedures performed in North America.

Conclusions

Secondary breast reduction is challenging and there remains international disparity with regard to pedicle choice for secondary procedures. Studies investigating outcome when the primary pedicle is unknown are scarce and provide incoherent recommendations. High-quality data is needed to provide evidence-based practice guidelines.

Level of Evidence III

This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authorswww.springer.com/00266
Pelvimetric and Nutritional Factors Predicting Surgical Difficulty in Laparoscopic Resection for Rectal Cancer Following Preoperative Chemoradiotherapy
Authors: Sun Yanwu , Chen Jianhua , Ye Chengwei , Lin Huiming , Lu Xingrong , Huang Ying , Chi Pan
Published: April 2021

Aim

Laparoscopic total mesorectal excision (LaTME) following preoperative chemoradiotherapy (PCRT) in locally advanced rectal cancer (LARC) is technically demanding. The present study is intended to evaluate predictive factors of surgical difficulty of LaTME following PCRT by using pelvimetric and nutritional factors.

Method

Consecutive LARC patients receiving LaTME after PCRT were included. Surgical difficulty was classified based upon intraoperative (operation time, blood loss, and conversion) and postoperative outcomes (postoperative hospital stay and morbidities). Pelvimetry was performed using preoperative T2‐weighted MRI. Nutritional factors such as albumin‐to‐globulin ratio (AGR) and prognostic nutritional index (PNI) were calculated. Multivariable logistic analysis was used to identify predictors of high surgical difficulty. A predictive nomogram was developed and validated internally.

Results

Among 294 patients included, 36 (12.4%) patients were graded as high surgical difficulty. Logistic regression analysis demonstrated that previous abdominal surgery (OR = 6.080, P = 0.001), tumor diameter (OR = 1.732, P = 0.003), intersphincteric resection (vs. low anterior resection, OR = 13.241, P < 0.001), interspinous distance (OR = 0.505, P = 0.009), and preoperative AGR (OR = 0.041, P = 0.024) were independently predictive of high surgical difficulty of LaTME after PCRT. Then, a predictive nomogram was built (C‐index = 0.867).

Conclusion

Besides previous abdominal surgery, type of surgery (intersphincteric resection), tumor diameter, and interspinous distance, we found that preoperative AGR could be useful for the prediction of surgical difficulty of LaTME after PCRT. A predictive nomogram for surgical difficulty may aid in planning an appropriate approach for rectal cancer surgery after PCRT.
MRI-based diagnosis and treatment of pediatric brain tumors: is tissue sample always needed?
Authors: Soleman Jehuda , Dvir Rina , Ben-Sira Liat , Yalon Michal , Boop Frederick , Constantini Shlomi , Roth Jonathan
Published: April 2021

Traditional management of newly diagnosed pediatric brain tumors (PBTs) consists of cranial imaging, typically magnetic resonance imaging (MRI), and is frequently followed by tissue diagnosis, through either surgical biopsy or tumor resection. Therapy regimes are typically dependent on histological diagnosis. To date, many treatment regimens are based on molecular biology. The scope of this article is to discuss the role of diagnosis and further treatment of PBTs based solely on MRI features, in light of the latest treatment protocols. Typical MRI findings and indications for surgical biopsy of these lesions are described.
Evolving patterns of sterodynamic sea-level rise under mitigation scenarios and insights from linear system theory
Authors: Wu Quran , Zhang Xuebin , Church John A. , Hu Jianyu , Gregory Jonathan M.
Published: April 2021

Long-term behaviour of sea-level rise is an important factor in assessing the impact of climate change on multi-century timescales. Under the stabilisation scenario RCP4.5, Sterodynamic Sea-Level (SdynSL) and ocean density change in the CMIP5 models exhibit distinct patterns over the periods before and after Radiative Forcing (RF) stabilisation (2000–2070 vs. 2100–2300). The stabilisation pattern is more geographically uniform and involves deeper penetration of density change than the transient pattern. In RCP2.6, 4.5 and 8.5, the spatiotemporal evolution of SdynSL change can be approximated as a linear combination of the transient and stabilisation patterns. Specifically, SdynSL change is dominated by the transient pattern when RF increases rapidly, but it is increasingly affected by the stabilisation pattern once RF starts to stabilise. The growth of the stabilisation pattern could persist for centuries after RF ceases increasing. The evolving patterns of SdynSL change can also be approximated as a linear system's responses (characterised by its Green’s function) to time-dependent boundary conditions. By examining SdynSL change simulated in linear system models with different estimates of Green's functions, we find that both the climatological ocean circulation and the ocean's dynamical response to RF play a role in shaping the patterns of SdynSL change. The linear system model is more accurate than the univariate pattern scaling in emulating the CMIP5 SdynSL change beyond 2100. The emergence of the stabilisation pattern leads to a 1–10% decrease in the ocean's expansion efficiency of heat over 2000–2300 in RCP2.6 and 4.5.
Neural representations underlying mental imagery as unveiled by representation similarity analysis
Authors: Boccia Maddalena , Sulpizio Valentina , Bencivenga Federica , Guariglia Cecilia , Galati Gaspare
Published: April 2021

It is commonly acknowledged that visual imagery and perception rely on the same content-dependent brain areas in the high-level visual cortex (HVC). However, the way in which our brain processes and organizes previous acquired knowledge to allow the generation of mental images is still a matter of debate. Here, we performed a representation similarity analysis of three previous fMRI experiments conducted in our laboratory to characterize the neural representation underlying imagery and perception of objects, buildings and faces and to disclose possible dissimilarities in the neural structure of such representations. To this aim, we built representational dissimilarity matrices (RDMs) by computing multivariate distances between the activity patterns associated with each pair of stimuli in the content-dependent areas of the HVC and HC. We found that spatial information is widely coded in the HVC during perception (i.e. RSC, PPA and OPA) and imagery (OPA and PPA). Also, visual information seems to be coded in both preferred and non-preferred regions of the HVC, supporting a distributed view of encoding. Overall, the present results shed light upon the spatial coding of imagined and perceived exemplars in the HVC.
Codon usage bias and environmental adaptation in microbial organisms
Authors: Arella Davide , Dilucca Maddalena , Giansanti Andrea
Published: April 2021

In each genome, synonymous codons are used with different frequencies; this general phenomenon is known as codon usage bias. It has been previously recognised that codon usage bias could affect the cellular fitness and might be associated with the ecology of microbial organisms. In this exploratory study, we investigated the relationship between codon usage bias, lifestyles (thermophiles vs. mesophiles; pathogenic vs. non-pathogenic; halophilic vs. non-halophilic; aerobic vs. anaerobic and facultative) and habitats (aquatic, terrestrial, host-associated, specialised, multiple) of 615 microbial organisms (544 bacteria and 71 archaea). Principal component analysis revealed that species with given phenotypic traits and living in similar environmental conditions have similar codon preferences, as represented by the relative synonymous codon usage (RSCU) index, and similar spectra of tRNA availability, as gauged by the tRNA gene copy number (tGCN). Moreover, by measuring the average tRNA adaptation index (tAI) for each genome, an index that can be associated with translational efficiency, we observed that organisms able to live in multiple habitats, including facultative organisms, mesophiles and pathogenic bacteria, are characterised by a reduced translational efficiency, consistently with their need to adapt to different environments. Our results show that synonymous codon choices might be under strong translational selection, which modulates the choice of the codons to differently match tRNA availability, depending on the organism’s lifestyle needs. To our knowledge, this is the first large-scale study that examines the role of codon bias and translational efficiency in the adaptation of microbial organisms to the environment in which they live.
Biangular Lines Revisited
Authors: Ganzhinov Mikhail , Szöllősi Ferenc
Published: April 2021

Line systems passing through the origin of the d-dimensional Euclidean space admitting exactly two distinct angles are called biangular. It is shown that the maximum cardinality of biangular lines is at least $$2(d-1)(d-2)$$

2
(
d
-
1
)
(
d
-
2
)

, and this result is sharp for $$d\in \{4,5,6\}$$

d
∈
{
4
,
5
,
6
}

. Connections to binary codes, few-distance sets, and association schemes are explored, along with their multiangular generalization.
3D-CT Evaluation of Swallowing: Metrics of the Swallowing Response Using Swallowing CT
Authors: Inamoto Yoko , González-Fernández Marlís , Saitoh Eiichi
Published: April 2021

Videofluoroscopy and videoendoscopy dramatically changed the evaluation and management of swallowing disorders. Later advancements in techniques for the instrumental evaluation of swallowing were limited by technique and positioning. The advent of 320-row area detector CT solved previous challenges and allowed for the study of swallowing physiology and dysphagia in greater detail. In this summary, we describe the history and evolution of CT technology and describe research and clinical applications for the evaluation of swallowing physiology and pathophysiology.
Rock Triaxial Tests: Global Deformation vs Local Strain Measurements—Implications
Authors: Perbawa A. , Gramajo E. , Finkbeiner T. , Santamarina J. C.
Published: April 2021

Accurate stress–strain measurements in triaxial tests are critical to compute reliable mechanical parameters. We focus on compliance at the interfaces between the specimen and endcaps, and test specimens under various triaxial conditions using different instrumentation protocols. The tested materials include aluminum, Eagle Ford shale, Berea sandstone, and Jubaila carbonate. Results obtained following common practice reveal that surface roughness at the specimen-endcap interfaces leads to marked seating effects, affects all cap-to-cap based measurements and hinders ultrasonic energy transmission. In particular, cap-to-cap deformation measurements accentuate hysteretic behavior, magnify biases caused by bending and tilting (triggered by uneven surfaces and misalignment), and affect the estimation of all rock parameters, from stiffness to Biot’s α-parameter. Higher confining pressure diminishes seating effects. Local measurements using specimen-bonded strain gauges are preferred (Note: mounting strain gauges on sleeves is ill-advised). We confirm that elastic moduli derived from wave propagation measurements are higher than quasi-static moduli determined from local strain measurements using specimen-bonded strain gauges, probably due to the lower strain level in wave propagation and preferential high-velocity travel path for first arrivals.
How to correctly apply Gaussian statistics in a non-stationary climate?
Authors: Steinacker Reinhold
Published: April 2021

Time series with a significant trend, as is now being the case for the temperature in the course of climate change, need a careful approach for statistical evaluations. Climatological means and moments are usually taken from past data which means that the statistics does not fit to actual data anymore. Therefore, we need to determine the long-term trend before comparing actual data with the actual climate. This is not an easy task, because the determination of the signal—a climatic trend—is influenced by the random scatter of observed data. Different filter methods are tested upon their quality to obtain realistic smoothed trends of observed time series. A new method is proposed, which is based on a variational principle. It outperforms other conventional methods of smoothing, especially if periodic time series are processed. This new methodology is used to test, how extreme the temperature of 2018 in Vienna actually was. It is shown that the new annual temperature record of 2018 is not too extreme, if we consider the positive trend of the last decades. Also, the daily mean temperatures of 2018 are not found to be really extreme according to the present climate. The real extreme of the temperature record of Vienna—and many other places around the world—is the strongly increased positive temperature trend over the last years.
Collagen metabolism as a regulator of proline dehydrogenase/proline oxidase-dependent apoptosis/autophagy
Authors: Palka Jerzy , Oscilowska Ilona , Szoka Lukasz
Published: April 2021

Recent studies on the regulatory role of amino acids in cell metabolism have focused on the functional significance of proline degradation. The process is catalysed by proline dehydrogenase/proline oxidase (PRODH/POX), a mitochondrial flavin-dependent enzyme converting proline into ∆1-pyrroline-5-carboxylate (P5C). During this process, electrons are transferred to electron transport chain producing ATP for survival or they directly reduce oxygen, producing reactive oxygen species (ROS) inducing apoptosis/autophagy. However, the mechanism for switching survival/apoptosis mode is unknown. Although PRODH/POX activity and energetic metabolism were suggested as an underlying mechanism for the survival/apoptosis switch, proline availability for this enzyme is also important. Proline availability is regulated by prolidase (proline supporting enzyme), collagen biosynthesis (proline utilizing process) and proline synthesis from glutamine, glutamate, α-ketoglutarate (α-KG) and ornithine. Proline availability is dependent on the rate of glycolysis, TCA and urea cycles, proline metabolism, collagen biosynthesis and its degradation. It is well established that proline synthesis enzymes, P5C synthetase and P5C reductase as well as collagen prolyl hydroxylases are up-regulated in most of cancer types and control rates of collagen biosynthesis. Up-regulation of collagen prolyl hydroxylase and its exhaustion of ascorbate and α-KG may compete with DNA and histone demethylases (that require the same cofactors) to influence metabolic epigenetics. This knowledge led us to hypothesize that up-regulation of prolidase and PRODH/POX with inhibition of collagen biosynthesis may represent potential pharmacotherapeutic approach to induce apoptosis or autophagic death in cancer cells. These aspects of proline metabolism are discussed in the review as an approach to understand complex regulatory mechanisms driving PRODH/POX-dependent apoptosis/survival.
Characterization of an ester-based core-multishell (CMS) nanocarrier for the topical application at the oral mucosa
Authors: Dommisch H. , Stolte KN. , Jager J. , Vogel K. , Müller R. , Hedtrich S. , Unbehauen M. , Haag R. , Danker K.
Published: April 2021

Objectives

Topical drug administration is commonly applied to control oral inflammation. However, it requires sufficient drug adherence and a high degree of bioavailability. Here, we tested the hypothesis whether an ester-based core-multishell (CMS) nanocarrier is a suitable nontoxic drug-delivery system that penetrates efficiently to oral mucosal tissues, and thereby, increase the bioavailability of topically applied drugs.

Material and methods

To evaluate adhesion and penetration, the fluorescence-labeled CMS 10-E-15-350 nanocarrier was applied to ex vivo porcine masticatory and lining mucosa in a Franz cell diffusion assay and to an in vitro 3D model. In gingival epithelial cells, potential cytotoxicity and proliferative effects of the nanocarrier were determined by MTT and sulphorhodamine B assays, respectively. Transepithelial electrical resistance (TEER) was measured in presence and absence of CMS 10-E-15-350 using an Endohm-12 chamber and a volt-ohm-meter. Cellular nanocarrier uptake was analyzed by laser scanning microscopy. Inflammatory responses were determined by monitoring pro-inflammatory cytokines using real-time PCR and ELISA.

Results

CMS nanocarrier adhered to mucosal tissues within 5 min in an in vitro model and in ex vivo porcine tissues. The CMS nanocarrier exhibited no cytotoxic effects and induced no inflammatory responses. Furthermore, the physical barrier expressed by the TEER remained unaffected by the nanocarrier.

Conclusions

CMS 10-E-15-350 adhered to the oral mucosa and adhesion increased over time which is a prerequisite for an efficient drug release. Since TEER is unaffected, CMS nanocarrier may enter the oral mucosa transcellularly.

Clinical relevance

Nanocarrier technology is a novel and innovative approach for efficient topical drug delivery at the oral mucosa.
Contemporary snapshot of tumor regression grade (TRG) distribution in locally advanced rectal cancer: a cross sectional multicentric experience
Authors: Germani Paola , Di Candido Francesca , Léonard Daniel , Cuicchi Dajana , Elmore Ugo , Allaix Marco Ettore , Barbieri Vittoria Pia , D’Allens Laura , Faes Seraina , Milani Marika , Caputo Damiano , Martinez Carmen , Grosek Jan , Caracino Valerio , Christou Niki , Roodbeen Sapho X. , Bracale Umberto , Wildeboer Aurelia , Usai Antonella , Benedetti Michele , Balani Alessandro , Piccinni Giuseppe , Catarci Marco , Millo Paolo , Bouvy Nicole , Corcione Francesco , Hompes Roel , Ris Frédéric , Basti Massimo , Tomazic Ales , Targarona Eduardo , Coppola Alessandro , Pietrabissa Andrea , Hahnloser Dieter , Adamina Michel , Viola Massimo , Morino Mario , Rosati Riccardo , Poggioli Gilberto , Kartheuser Alex , Spinelli Antonino , de Manzini Nicolò ,   the TRG Snapshot Study Group, Bellio Gabriele , Iacuzzo Cristiana , Zucca Annalisa , Corleone Pio , Giudici Fabiola , Palmisano Silvia , Carvello Michele , Remue Christophe , Bachmann Radu , Lombard Nicolas , Pirlet Christine , Ryckx Andries , Massaron Simonetta , Pugliese Luigi , Coppola Roberto , Ferrari Cecilia , Castiglioni Simone , Ponte Elisa , Concina Serena , Piveteau Arthur , An Yongbo , Cagnazzo Emanuela , Troian Marina
Published: April 2021

Pre-operative chemoradiotherapy (CRT) followed by surgical resection is still the standard treatment for locally advanced low rectal cancer. Nowadays new strategies are emerging to treat patients with a complete response to pre-operative treatment, rendering the optimal management still controversial and under debate. The primary aim of this study was to obtain a snapshot of tumor regression grade (TRG) distribution after standard CRT. Second, we aimed to identify a correlation between clinical tumor stage (cT) and TRG, and to define the accuracy of magnetic resonance imaging (MRI) in the restaging setting. Between January 2017 and June 2019, a cross sectional multicentric study was performed in 22 referral centers of colon-rectal surgery including all patients with cT3-4Nx/cTxN1-2 rectal cancer who underwent pre-operative CRT. Shapiro–Wilk test was used for continuous data. Categorical variables were compared with Chi-squared test or Fisher’s exact test, where appropriate. Accuracy of restaging MRI in the identification of pathologic complete response (pCR) was determined evaluating the correspondence with the histopathological examination of surgical specimens.

In the present study, 689 patients were enrolled. Complete tumor regression rate was 16.9%. The “watch and wait” strategy was applied in 4.3% of TRG4 patients. A clinical correlation between more advanced tumors and moderate to absent tumor regression was found (p = 0.03). Post-neoadjuvant MRI had low sensibility (55%) and high specificity (83%) with accuracy of 82.8% in identifying TRG4 and pCR.

Our data provided a contemporary description of the effects of pre-operative CRT on a large pool of locally advanced low rectal cancer patients treated in different colon-rectal surgical centers.
Vibration investigation for telecom structures with smartphone camera: case studies
Authors: Wang Ying , Brownjohn James , Jiménez Capilla Jose Alfonso , Dai Kaoshan , Lu Wensheng , Koo Ki Young
Published: April 2021

Telecom structures such as high guyed masts are tall and flexible, so that not only the main structure but also the components (i.e., guy cable and antenna) suffer from vibrations induced by wind or earthquakes. The installation of contact inertial accelerometers for high guyed mast cables or antenna can be logistically challenging and the original vibration state may be influenced by these sensors. With convenient implementation and acceptable accuracy, computer vision technologies have been applied for vibration tests both in labs and field. In this paper, videos taken with smartphone cameras are processed to extract guy cable and antenna vibration information for telecom structures and, as a result, providing an efficient cost-effective method for vibration investigation of this type of structure. The video processing method can also be used in similar cases for other structures.
Comparison of different finite element model updates based on experimental onsite testing: the case study of San Giovanni in Macerata
Authors: Baggio Carlo , Sabbatini Valerio , Santini Silvia , Sebastiani Claudio
Published: April 2021

Understanding the behavior of historic structures that have undergone structural changes, restorations, and damage over time is still a significant challenge for structural engineers, particularly in those countries subject to high seismic risk, such as Italy. The study of built heritage for its prevention and conservation is an active research topic, due to the numerous uncertainties present in historic structures. Finite element modelling has become the most common and accessible method to study the behavior of complex masonry structures, however, the gap between numerical and experimental analysis may lead to erroneous results. Model updating techniques can reduce the discrepancy between the behavior of the numerical models and the testing results. The goal of this work is to illustrate a methodology to integrate the information derived from local, global, and geotechnical investigations into the finite element model of the masonry historical church of San Giovanni in Macerata, considering the Douglas–Reid model updating method. The PRiSMa laboratory of Roma Tre University carried out local investigations such as sonic tomography, video endoscopy and double flat jack tests, along with five ambient vibration tests that were processed through the operational modal analysis to extrapolate the dynamic properties of the building (modal frequency, modal shape vector and modal damping). The combined use of global, local and geotechnical information implemented in the methodology effectively reduced the uncertainties of the model and led the refinement and validation of the most relevant structural parameters.
A multiscale DEM–FEM coupled approach for the investigation of granules as crash-absorber in ship building
Authors: Chaudry Mohsin Ali , Woitzik Christian , Düster Alexander , Wriggers Peter
Published: April 2021

This paper covers a numerical analysis of a novel approach to increasing the crashworthiness of double hull ships. As proposed in Schöttelndreyer (Füllstoffe in der Konstruktion: ein Konzept zur Verstärkung vonSchiffsseitenhüllen, Technische Uni-versitt Hamburg, Hamburg, 2015), it involves the usage of granular materials in the cavity of the double hull ship. For the modeling of this problem, the discrete element method (DEM) is used for the granules while the finite element method is used for the ship’s structure. In order to account for the structural damage caused by collision, a gradient-enhanced ductile damage model is implemented. In addition to avoid locking, an enhanced strain-based formulation is used. For large-scale problems such as the one in the current study, modeling of all granules with realistic size can be computationally expensive. A two-scale model based on the work of Wellmann and Wriggers (Comput Methods Appl Mech Eng 205:46–58, 2012) is applied—and the region of significant localization is modeled with the DEM, while a continuum model is used for the other regions. The coupling of both discretization schemes is based on the Arlequin method. Numerical homogenization is used to estimate the material parameters of the continuum region with the granules. This involves the usage of meshless interpolation functions for the projection of particle displacement and stress onto a background mesh. Later, the volume-averaged stress and strain within the representative volume element is used to estimate the material parameters. At the end, the results from the combined numerical model are compared with the results from the experiments given in Woitzik and Düster (Ships Offshore Struct 1–12, 2020). This validates both the accuracy of the numerical model and the proposed idea of increasing the crashworthiness of double hull vessels with the granular materials.
Smooth covers of moduli stacks of Riemann surfaces with symmetry
Authors: Perroni Fabio
Published: April 2021

We construct explicitly a finite cover of the moduli stack of compact Riemann surfaces with a given group of symmetries by a smooth quasi-projective variety.
A Novel Fault Detection, Identification and Prediction Approach for Autonomous Vehicle Controllers Using SVM
Authors: Biddle Liam , Fallah Saber
Published: April 2021

Faults that develop in vehicle sensors have the potential to propagate unchecked throughout control systems if undetected. Automatic fault diagnosis and health monitoring algorithms will become necessary as automotive applications become more autonomous. The current fault diagnosis systems are not effective for complex systems such as autonomous cars where the case of simultaneous faults in different sensors is highly possible. Therefore, this paper proposes a novel fault detection, isolation and identification architecture for multi-fault in multi-sensor systems with an efficient computational burden for real-time implementation. Support Vector Machine techniques are used to detect and identify faults in sensors for autonomous vehicle control systems. In addition, to identify degrading performance in a sensor and predict the time at which a fault will occur, a novel predictive algorithm is proposed. The effectiveness and accuracy of the architecture in detecting and identifying multiple faults as well as the accuracy of the proposed predictive fault detection algorithm are verified through a MATLAB/IPG CarMaker co-simulation platform. The results present detection and identification accuracies of 94.94% and 97.01%, respectively, as well as a prediction accuracy of 75.35%.
An updated review on boron removal from water through adsorption processes
Authors: Bhagyaraj Sneha , Al-Ghouti Mohammad A. , Kasak Peter , Krupa Igor
Published: April 2021

Boron is an essential micronutrient that has raised much interest, given the narrow balance between its necessity and toxicity. Both natural and anthropogenic emissions of boron into water sources can eventually deteriorate water quality and endanger the ecosystem. In this review, we first present a general outline of the importance of boron, boron chemistry in water, boron contamination, and its consequences followed by the recent progress in boron removal methods based on adsorption. The adsorbents for deboronation can generally be classified based on the functional groups present; chelating groups, metal oxides, and layered double hydroxides. To comprehensively address these adsorption methods, a detailed discussion on the reaction mechanism of each system is done followed by a summary of the progress in the field during the past 5 years. Finally, some characterization techniques used in deboronation studies and suggestions for future research and applications together with possible improvements to the existing systems are presented.

Graphical abstract
Poetry and Poetics in the Presocratic Philosophers
Authors: Mackenzie Tom
Published: April 2021

Of the Presocratic thinkers traditionally credited with the foundation of Greek philosophy, Xenophanes, Parmenides and Empedocles are exceptional for writing in verse. This is the first book-length, literary-critical study of their work. It locates the surviving fragments in their performative and wider cultural contexts, applying intertextual and intratextual analyses in order to reconstruct the significance and impact they conveyed for ancient audiences and readers. Building on insights from literary theory and the philosophy of literature, the book sheds new light on these authors' philosophical projects and enriches our appreciation of their works as literary artefacts. It also expands our knowledge of the genres in which they wrote, of the literary culture of the Western Greek world, and of the development of Greek poetics from the Archaic to the Classical periods, exposing the influence of these thinkers on more famous Sophistic and Platonic ideas about literature.
Examining the Relationship between Land Values and Credit Availability
Authors: Sant’Anna Ana Claudia , Cowley Cortney , Katchova Ani L.
Published: April 2021

Increased credit availability facilitates land acquisition, but higher land values also hinder it. We investigate the impact of credit availability on land values, after regulatory changes in the lending system. We build an index of increased credit availability using Federal Reserve and Federal Deposit Insurance Corporation data. County-level panel fixed effects estimations are performed controlling for land value determinants, credit availability, and county-level macroeconomic factors. We find that estimating the effects of credit availability separately masks its total effect. Results show a 0.1 change in the index for increased credit availability is associated with 1.64–1.96% increase in land values.
Deep ice-core drilling to 800 m at Dome A in East Antarctica
Authors: Hu Zhengyi , Shi Guitao , Talalay Pavel , Li Yuansheng , Fan Xiaopeng , An Chunlei , Zhang Nan , Li Chuanjin , Liu Ke , Yu Jinhai , Yang Cheng , Li Bing , Liu Bowen , Ma Tianming
Published: April 2021

A deep ice core was drilled at Dome A, Antarctic Plateau, East Antarctica, which started with the installation of a casing in January 2012 and reached 800.8 m in January 2017. To date, a total of 337 successful ice-core drilling runs have been conducted, including 118 runs to drill the pilot hole. The total drilling time was 52 days, of which eight days were required for drilling down and reaming the pilot hole, and 44 days for deep ice coring. The average penetration depths of individual runs were 1 and 3.1 m for the pilot hole drilling and deep ice coring, respectively. The quality of the ice cores was imperfect in the brittle zone (650−800 m). Some of the troubles encountered are discussed for reference, such as armoured cable knotting, screws falling into the hole bottom, and damaged parts, among others.
Hospitals Disaster Preparedness and Management in the Eastern Province of the Kingdom of Saudi Arabia: A Cross-sectional study
Authors: Alruwaili Abdullah , Islam Md Shahidul , Usher Kim
Published: April 2021

Objective:

The current study was conducted to assess disaster preparedness of hospitals in the Eastern region of Saudi Arabia.

Methods:

A descriptive cross-sectional study of all hospitals in the Eastern Region of KSA was conducted between July 2017 and July 2018. The included hospitals were selected using convenience sampling. The questionnaire was distributed together with an official letter providing information about the aim and objectives of the study as well as ethical issues guiding their participation in the exercise.

Results:

All the included hospitals had a disaster plan that was completely accessible by all staff members. About 70% of the included hospitals established an educational program on disaster preparedness once per year. Assessment of hospital disaster preparedness was conducted using disaster drills in 62 (n= 98%) of the hospitals. However, only 9.5% of the hospitals had post-disaster recovery assistance programs like counseling and support services.

Conclusion:

Most hospitals involved in this study had sufficient resources for disaster management; however, the overall effectiveness of hospitals’ disaster preparedness was slight to moderate. Some recommendations to improve hospitals’ disaster preparedness should be proposed, including improved staff training and testing, better communications and safety procedures, and adoption of a holistic approach for disaster management.
A Note on the Epistemological Value of Pretense Imagination
Authors: Schoonen Tom
Published: April 2021

Pretense imagination is imagination understood as the ability to recreate rational belief revision. This kind of imagination is used in pretend-play, risk-assessment, etc. Some even claim that this kind of hypothetical belief revision can be grounds to justify new beliefs in conditionals, in particular conditionals that play a foundational role in the epistemology of modality. In this paper, I will argue that it cannot. I will first provide a very general theory of pretense imagination, which I formalise using tools from dynamic epistemic logic. As a result, we can clearly see that pretense imagination episodes are build up out of two kinds of imaginative stages, so I will present an argument by cases. This argument shows that pretense imagination might indeed provide us with justification for believing certain conditionals. Despite this, I will argue that these are not the kind of conditionals that allow pretense imagination to play a foundational role in the epistemology of modality.
Providing safe care for patients in the coronavirus disease 2019 (COVID-19) era: A case series evaluating risk for hospital-associated COVID-19
Authors: Habermann Elizabeth B. , Tande Aaron J. , Pollock Benjamin D. , Neville Matthew R. , Ting Henry H. , Sampathkumar Priya
Published: April 2021

Objective:

We evaluated the risk of patients contracting coronavirus disease 2019 (COVID-19) during their hospital stay to inform the safety of hospitalization for a non–COVID-19 indication during this pandemic.

Methods:

A case series of adult patients hospitalized for 2 or more nights from May 15 to June 15, 2020 at large tertiary-care hospital in the midwestern United States was reviewed. All patients were screened at admission with the severe acute respiratory coronavirus virus 2 (SARS-CoV-2) polymerase chain reaction (PCR) test. Selected adult patients were also tested by IgG serology. After dismissal, patients with negative serology and PCR at admission were asked to undergo repeat serologic testing at 14–21 days after discharge. The primary outcome was healthcare-associated COVID-19 defined as a new positive SARS-CoV-2 PCR test on or after day 4 of hospital stay or within 7 days of hospital dismissal, or seroconversion in patients previously established as seronegative.

Results:

Of the 2,068 eligible adult patients, 1,778 (86.0%) completed admission PCR testing, while 1,339 (64.7%) also completed admission serology testing. Of the 1,310 (97.8%) who were both PCR and seronegative, 445 (34.0%) repeated postdischarge serology testing. No healthcare-associated COVID-19 cases were detected during the study period. Of 1,310 eligible PCR and seronegative adults, no patients tested PCR positive during hospital admission (95% confidence interval [CI], 0.0%–0.3%). Of the 445 (34.0%) who completed postdischarge serology testing, no patients seroconverted (0.0%; 95% CI, 0.0%–0.9%).

Conclusion:

We found low likelihood of hospital-associated COVID-19 with strict adherence to universal masking, physical distancing, and hand hygiene along with limited visitors and screening of admissions with PCR.
Ameliorative effect of enhanced Fischer ratio flaxseed protein hydrolysate in combination with antioxidant micronutrients on ethanol-induced hepatic damage in a rat model
Authors: Ume Salma Nida , Govindaraju K. , Gnanesh Kumar Belur Shivappa , Muthukumar S.P. , Jyothi Lakshmi A.
Published: April 2021

Alcohol abuse causes severe metabolic abnormalities inducing hepatic damage and malnutrition. Since higher Fischer ratio proteins have therapeutic value in liver diseases, an investigation was undertaken to study the ameliorative effect of the enhanced Fischer ratio flaxseed protein hydrolysate (EFR-FPH) alone and in combination with antioxidant micronutrients on ethanol-induced hepatotoxicity in a rat model. The EFR-FPH was prepared by dual enzymatic hydrolysis and charcoal treatment of flaxseed protein. The ratio of the branched-chain:aromatic amino acids (Fischer ratio) was found to be 7·08. The EFR-FPH, characterised using LC-MS/MS, showed the abundance of free leucine and isoleucine compared with phenylalanine and tyrosine. The matrix-assisted laser desorption/ionisation-time of flight MS analysis revealed the larger peptides present in EFR-FPH with mass 2·3 kDa. The EFR-FPH improved the nutritional status, liver function and antioxidant defense in the ethanol hepatotoxicity-induced rat model. The hepatoprotective effect of EFR-FPH was significantly enhanced when combined with selenium or vitamin E. Ethanol-induced changes in the liver tissue were effectively suppressed in the groups receiving EFR-FPH. Flaxseed-based hepatoprotective dietary supplement was formulated incorporating an optimum level of EFR-FPH (10 %) based on sensory acceptability and was fortified with selenium and vitamin E. The hepatoprotective formulation significantly lowered aspartate transaminase, alanine transaminase, alkaline phosphatase and bilirubin by 47, 61, 55 and 78 %, respectively, and improved the antioxidant defense in the ethanol hepatotoxicity-induced rat model. The current investigation suggests that EFR-FPH in synergy with antioxidant micronutrients is potent in ameliorating ethanol-induced hepatotoxicity and has a potential to form a hepatoprotective dietary supplement.
Maternal supplementation with Bacillus altitudinis spores improves porcine offspring growth performance and carcass weight
Authors: Crespo-Piazuelo Daniel , Gardiner Gillian E. , Ranjitkar Samir , Bouwhuis Meike A. , Ham Rebecca , Phelan John P. , Marsh Alan , Lawlor Peadar G.
Published: April 2021

The objective of this study was to evaluate the effect of feeding Bacillus altitudinis spores to sows and/or offspring on growth and health indicators. On day (D) 100 of gestation, twenty-four sows were selected and grouped as: control (CON), fed with a standard diet; and probiotic (PRO), fed the standard diet supplemented with B. altitudinis WIT588 spores from D100 of gestation until weaning. Offspring (n 144) from each of the two sow treatments were assigned to either a CON (no probiotic) or PRO (B. altitudinis-supplemented) treatment for 28 d post-weaning (pw), resulting in four treatment groups: (1) CON/CON, non-probiotic-supplemented sow/non-probiotic-supplemented piglet; (2) CON/PRO, non-probiotic-supplemented sow/probiotic-supplemented piglet; (3) PRO/CON, probiotic-supplemented sow/non-probiotic-supplemented piglet and (4) PRO/PRO, probiotic-supplemented sow/probiotic-supplemented piglet. B. altitudinis WIT588 was detected in the faeces of probiotic-supplemented sows and their piglets, and in the faeces and intestine of probiotic-supplemented piglets. Colostrum from PRO sows had higher total solids (P = 0·02), protein (P = 0·04) and true protein (P = 0·05), and lower lactose (P < 0·01) than colostrum from CON sows. Maternal treatment improved offspring feed conversion ratio at D0–14 pw (P < 0·001) and increased offspring body weight at D105 and D127 pw (P = 0·01), carcass weight (P = 0·05) and kill-out percentage (P < 0·01). It also increased small intestinal absorptive capacity and impacted the haematological profile of sows and progeny. There was little impact of pw treatment on any of the parameters measured. Overall, the lifetime growth benefits in the offspring of B. altitudinis-supplemented sows offer considerable economic advantages for pig producers in search of alternatives to in-feed antibiotics/zinc oxide.
Railroads and Reform: How Trains Strengthened the Nation State
Authors: Cermeño Alexandra L. , Enflo Kerstin , Lindvall Johannes
Published: April 2021

This paper examines the relationship between the coming of the railroads, the expansion of primary education, and the introduction of national school curricula. Using fine-grained data on local education outcomes in Sweden in the nineteenth century, the paper tests the idea that the development of the railroad network enabled national school inspectors to monitor remote schools more effectively. In localities to which school inspectors could travel by rail, a larger share of children attended permanent public schools and took classes in nation-building subjects such as geography and history. By contrast, the parochial interests of local and religious authorities continued to dominate in remote areas school inspectors could not reach by train. The paper argues for a causal interpretation of these findings, which are robust for the share of children in permanent schools and suggestive for the content of the curriculum. The paper therefore concludes that the railroad, the defining innovation of the First Industrial Revolution, mattered directly for the state's ability to implement public policies.
Asset Specificity, Corporate Protection and Trade Policy: Firm-Level Evidence from Antidumping Petitions in Nineteen Jurisdictions
Authors: Egerod Benjamin C. K. , Justesen Mogens K.
Published: April 2021

This letter provides firm-level evidence that policy makers tailor trade policy to suit selected firms. It argues that firms with higher levels of specific assets find it more costly to reorganize production, and are hurt more by international competition. In response, policy makers grant more trade protection to firms with fixed assets. Since protectionism is costly, firms compete for it, which creates diffusion dynamics in which the protection granted to one firm affects the protection granted to others. This claim is tested utilizing the special role antidumping duties (ADDs) play in international trade, and combining petitions for ADDs with financial data on the firms filing them in a unique dataset. Using spatial autoregressive models, the authors find that firms with specific assets are granted more protection. However, diffusion dynamics differ within and between groups of firms producing the same good. This suggests that firms can partly shape their own level of trade protection.
Grain-filling of superior spikelets and inferior spikelets for japonica rice under low-amplitude warming regime in lower reaches of Yangtze River Basin
Authors: Dou Zhi , Zhang Haixiang , Chen Wenzhu , Li Ganghua , Liu Zhenghui , Ding Chengqiang , Chen Lin , Wang Shaohua , Ding Yanfeng , Tang She
Published: April 2021

Grain-filling, as the final growth stage of rice, is sensitive to environmental temperature change. Previous studies mainly concerned about the effects of high temperature stress during grain-filling on rice growth, and most experiments were carried out with pot for cultivating rice and greenhouse for warming. This research investigated the response of rice grain-filling of superior spikelets (SS) and inferior spikelets (IS) of two japonica cultivars to elevated temperature during grain-filling stage under open-field warming conditions in lower reaches of Yangtze River Basin using free-air temperature enhancement facility. Results indicated that rice yield was not significantly changed by warming less than 4°C. SS and IS showed different responses to elevated temperature during the grain-filling stage, whereas there were similar trends between two cultivars and years. For SS, although elevated temperature enhanced its filling rate during the early grain-filling period, and caused a shorter grain-filling period and a lighter grain weight; for IS, elevated temperature improved its grain weight by enhancing its filling rate during middle and late grain-filling period due to the increased number of days with suitable temperature. For both SS and IS, key starch biosynthesis enzymes and indole-3-acetic acid content exhibited generally a similar dynamics trend with grain-filling rates, and these sink strength parameters presented higher levels under elevated temperature relative to natural temperature for IS during middle and late grain-filling period. Consequently, warming less than 4°C presented different influences on SS and IS; the improvement of IS filling under warming regime was associated with the intensification of grain sink strength.
Low-tillering winter wheat cultivars are more adaptable to late sowing
Authors: Yin Lijun , Zhang Chengxiang , Liu Kaizhen , Wang Xiaoyan
Published: April 2021

Global warming increases the risk of pests and weeds before wintering, and decreases the grain yield of winter wheat. Therefore, the sowing date should be delayed properly. But the variety of winter wheat that can adapt to late sowing remains unclear. Here, we selected two winter wheat cultivars and evaluated four sowing date treatments on 1 October (early sowing), 8 (normal sowing), 15 (late sowing) and 22 (latest sowing) over two wheat-growing seasons at the experimental Station of Shandong Agricultural University (35°96′N, 117°06′E), Daiyue District, Taian, Shandong, China. We examined the effects of sowing date on a few traits, and found that, compared with normal sowing, though spike number decreased, grain yield was maintained above 9300 kg/ha under late and latest sowing. The main reason was that the more accumulated N from jointing to anthesis resulted in a higher grain number per spike. The higher net photosynthetic rate after anthesis, through optimizing N distribution in the canopy and increasing Rubisco content of flag leaves, improved dry matter accumulation rate and contribution ratio of vegetative organs, ultimately, ensured consistent grain weight. The grain yield of high-tillering winter wheat cultivars decreased from 9370 to 8346 kg/ha. The main reason was that spike number, accumulated N from jointing to anthesis and net photosynthetic rate decreased significantly, which reduced the dry matter accumulation rate, and only satisfied less grains to achieve consistent grain weight. Therefore, low-tillering winter wheat cultivars are more adaptable to late sowing, and can reduce the harm of global warming.