bluuebunny/crossref_metadata_2025 huggingface dataset:
Electrogenerated chemiluminescence at a 9,10-diphenylanthracene/polyvinyl butyral film modified electrode with a tetraphenylborate coreactant
Authors: Zholudov Yuriy T. , Xu Guobao
Published: June 2018

A tetraphenylborate coreactant provides efficient ECL excitation of fluorophores immobilized on the electrode surface.
Ultrasensitive detection of nucleic acids based on dually enhanced fluorescence polarization
Authors: Wang Bin , Ren Dahai , You Zheng , Yalikun Yaxiaer , Tanaka Yo
Published: June 2018

Increase of the molecular volume and quenching effect induced by AuNP conjugation can both enhance the fluorescence polarization of Alexa488.
Correction: Correcting the effect of hematocrit in whole blood coagulation analysis on paper-based lateral flow device
Authors: Li Hua , Han Daewoo , Pauletti Giovanni M. , Hegener Michael A. , Steckl Andrew J.
Published: June 2018

Correction for ‘Correcting the effect of hematocrit in whole blood coagulation analysis on paper-based lateral flow device’ by Hua Li et al., Anal. Methods, 2018, DOI: 10.1039/c8ay00192h.
White perovskite based lighting devices
Authors: Bidikoudi M. , Fresta E. , Costa R. D.
Published: June 2018

Hybrid organic–inorganic and all-inorganic metal halide perovskites have been one of the most intensively studied materials during the last few years.
Pd(ii)-Catalyzed gamma-C(sp3)–H alkynylation of amides: selective functionalization of R chains of amides R1C(O)NHR
Authors: Landge Vinod G. , Parveen Ayisha , Nandakumar Avanashiappan , Balaraman Ekambaram
Published: June 2018

The first example of palladium(ii)-catalyzed alkynylation of an unactivated gamma C(sp3)–H bond of alkyl amides (cyclic, linear, and amino acids) is reported.
New near-infrared rhodamine dyes with large Stokes shifts for sensitive sensing of intracellular pH changes and fluctuations
Authors: Zhang Yibin , Xia Shuai , Fang Mingxi , Mazi Wafa , Zeng Yanbo , Johnston Taylor , Pap Adam , Luck Rudy L. , Liu Haiying
Published: June 2018

New near-infrared rhodamine dyes with large Stokes shifts were developed and applied for sensitive detection of cellular pH changes and fluctuations by incorporating an additional amine group with fused rings.
Macrocycle crosslinked mesoporous polymers for ultrafast separation of organic dyes
Authors: Zhao Qian , Liu Yu
Published: June 2018

Mesoporous polymers were synthesized by interfacial polymerization of macrocycles (sulfonatocalix[4]arenes and pillar[5]arenes) and terephthaloyl chloride.
A comparative study of graphene growth on SiC by hydrogen-CVD or Si sublimation through thermodynamic simulations
Authors: Dagher Roy , Blanquet Elisabeth , Chatillon Christian , Journot Timotée , Portail Marc , Nguyen Luan , Cordier Yvon , Michon Adrien
Published: June 2018

Thermodynamic simulations of SiC hydrogen annealing illustrating the impossibility of graphene formation due to the high pressure of C–H gases.
Generalization of the elastic network model for the study of large conformational changes in biomolecules
Authors: Poma Adolfo B. , Li Mai Suan , Theodorakis Panagiotis E.
Published: June 2018

The generalized elastic network (GEN) model enables the study of large conformational changes in proteins.
Covalent functionalization of two-dimensional group 14 graphane analogues
Authors: Huey Warren L. B. , Goldberger Joshua E.
Published: June 2018

The sp3-hybridized group 14 graphane analogues are a unique family of 2D materials in which every atom requires a terminal ligand for stability.
Omnipotent phosphorene: a next-generation, two-dimensional nanoplatform for multidisciplinary biomedical applications
Authors: Qiu Meng , Ren Wen Xiu , Jeong Taeho , Won Miae , Park Geun Young , Sang David Kipkemoi , Liu Li-Ping , Zhang Han , Kim Jong Seung
Published: June 2018

Phosphorene, also known as single- or few-layer black phosphorus (FLBP), is a new member of the two-dimensional (2D) material family and has attracted significant attention in recent years for bio-applications.
Access to a pair of ambiphilic phosphine–borane regioisomers by rhodium-catalyzed hydroboration
Authors: Nichols Brian R. , Akhmedov Novruz G. , Petersen Jeffrey L. , Popp Brian V.
Published: June 2018

First reported method to achieve highly regioselective branched ambiphilic product from the hydroboration of diphenylvinylphosphine.
Impacts of glycation and transglutaminase-catalyzed glycosylation with glucosamine on the conformational structure and allergenicity of bovine β-lactoglobulin
Authors: Yuan Fangzhou , Ahmed Ishfaq , Lv Liangtao , Li Zhaojie , Li Zhenxing , Lin Hong , Lin Hang , Zhao Jinxia , Tian Shenglan , Ma Jiaju
Published: June 2018

β-Lactoglobulin (β-LG) is recognized as the major milk allergen.
Bis(methoxypropyl) ether-promoted oxidation of aromatic alcohols into aromatic carboxylic acids and aromatic ketones with O2 under metal- and base-free conditions
Authors: Liu Kai-Jian , Jiang Si , Lu Ling-Hui , Tang Ling-Li , Tang Shan-Shan , Tang Hai-Shan , Tang Zilong , He Wei-Min , Xu Xinhua
Published: June 2018

A practical and eco-friendly protocol for the oxidation of alcohols into carboxylic acids and ketones under metal-, base- and additive-free conditions is reported.
Versatile catalysis of iron: tunable and selective transformation of biomass-derived furfural in aliphatic alcohol
Authors: Zhang Zhenya , Tong Xinli , Zhang Haigang , Li Yongdan
Published: June 2018

A highly efficient and catalytic valorization of biomass-derived furfural to produce value-added chemicals has been developed with the Fe@C catalyst under O2 or H2 atmosphere.
Mechanochemistry for “no solvent, no base” preparation of hydantoin-based active pharmaceutical ingredients: nitrofurantoin and dantrolene
Authors: Colacino Evelina , Porcheddu Andrea , Halasz Ivan , Charnay Clarence , Delogu Francesco , Guerra Ruben , Fullenwarth Julien
Published: June 2018

The gram-scale mechanochemical preparation of marketed drugs Nitrofurantoin and Dantrolene is herein reported.
Accuracy improvement of iron ore analysis using laser-induced breakdown spectroscopy with a hybrid sparse partial least squares and least-squares support vector machine model
Authors: Guo Y. M. , Guo L. B. , Hao Z. Q. , Tang Y. , Ma S. X. , Zeng Q. D. , Tang S. S. , Li X. Y. , Lu Y. F. , Zeng X. Y.
Published: June 2018

A hybrid sparse partial least squares and least-squares support vector machine model was proposed to improve the accuracy of iron ore analysis using LIBS.
Feedback control for defect-free alignment of colloidal particles
Authors: Gao Yu , Lakerveld Richard
Published: June 2018

A novel feedback control method to align colloidal particles reliably via directed self-assembly in a microfluidic device is presented.
Curcumin-based pyrazoline analogues as selective inhibitors of human monoamine oxidase A
Authors: Nath Chandrani , Badavath Vishnu Nayak , Thakur Abhishek , Ucar Gulberk , Acevedo Orlando , Mohd Siddique Mohd Usman , Jayaprakash Venkatesan
Published: June 2018

Chlorine substitution on a 3,5-diphenyl-pyrazoline derivative enabled potent and selective inhibition of hMAO-A; calculations suggest an “aromatic sandwich” orientation is responsible.
Synthesis and characterization of Co3O4 immobilized on dipeptide-functionalized silica-coated magnetite nanoparticles as a catalyst for the selective aerobic oxidation of alcohols
Authors: Khodaei Mohammad Mehdi , Dehghan Mahsa
Published: June 2018

A supermagnetic core–shell nanocatalyst functionalized with a dipeptide ligand as a recyclable catalyst for the selective oxidation of alcohols.
PyrroleN-alkyl side chain effects on the properties of pyrrolo[3,4-c]pyrrole-1,3-dione-based polymers for polymer solar cells
Authors: Tamilavan Vellaiappillai , Lee Jihoon , Lee Dal Yong , Agneeswari Rajalingam , Jung Yun Kyung , Jin Youngeup , Jeong Jung Hyun , Hyun Myung Ho , Park Sung Heum
Published: June 2018

This study confirmed that the insertion of a 2-octyldodecyl instead of an-octyl group greatly alters the properties of the resulting PPD-based polymers.
A conjugate of jasmonic acid and tetrapeptide Tyr-Tyr-Lys-Ser-NH2 as a potential ingredient for skin care products – synthesis and characterization
Authors: Olejnik Anna , Sliwowska Alicja , Nowak Izabela
Published: June 2018

A conjugate of jasmonic acid and a tetrapeptide was synthesized and it might be used as a promising active ingredient in topical applications.
Facile one-pot synthesis of well-defined coaxial sulfur/polypyrrole tubular nanocomposites as cathodes for long-cycling lithium–sulfur batteries
Authors: Wei Wenli , Du Pengcheng , Liu Dong , Wang Qi , Liu Peng
Published: June 2018

A facile one-pot method was established to fabricate the well-defined core–shell structured coaxial sulfur/polypyrrole tubular nanocomposites as cathodes for long-cycling Li–S batteries.
Balancing steric and electronic effects of bidentate, mixed P,N ligands to control Kumada catalyst transfer polycondensation of a sterically hindered thiophene
Authors: Hameury S. , Gourlaouen C. , Sommer M.
Published: June 2018

Screening various P,N ligands to control KCTP of a sterically hindered thiophene reveals an oxazoline-based ligand most effective.
Controlling the residence time of a bouncing drop with asymmetric shaping
Authors: Yun Sungchan
Published: June 2018

Bouncing dynamics of asymmetric drops on non-wetted surfaces show shorter residence times than spherical drops.
MiR-21 in extracellular vesicles contributes to the growth of fertilized eggs and embryo development in mice
Authors: Lv Chao , Yu Wen-Xian , Wang Yan , Yi Da-Jing , Zeng Ming-Hua , Xiao Hong-Mei
Published: June 2018

Human preimplantation embryo development is susceptible to high rates of early embryo wastage. We determined the miR-21 expression of extracellular vesicles (EVs) in fertilized eggs and embryos of varying stages and their response to miR-21 microinjection. Sexually mature female and male mice were mated. Next, the expression and immunohistochemistry intensity of surface markers (CD9 and CD63) of EVs were detected in pregnant and non-pregnant mice. Exosomes were co-cultured with embryos for detection of blastocyst formation rate, and embryo apoptosis. Moreover, the expressions of Bcl-2 associated X protein (Bax), B cell lymphoma 2 (Bcl-2), and octamer-binding transcription factor-4 (Oct4) were determined. Finally, we detected miR-21 expression in EVs of uterus in pregnant mice, in embryos after embryo implantation and after embryo co-cultured with exosomes in uterine luminal fluid. MiR-21 was up-regulated in EVs of uterus, and higher immunohistochemistry intensity of CD9 and CD63, suggesting more EVs secreted in uterine luminal fluid in pregnant mice. After microinjection, miR-21 inhibitor suppresses embryo development of mice. Moreover, embryos co-cultured with exosomes display higher blastocyst formation rate, reduced apoptotic rate of embryos in pregnant mice. In addition, miR-21 was down-regulated with the development of embryos after embryo implantation, while miR-21 expression in embryos was up-regulated by exosomes in uterine luminal fluid in the pregnant mice. Increased miR-21 expression in EVs of uterus and increased miR-21 expression after implantation, which indicate the key role in the growth of fertilized eggs and embryo development in mice.
0.18 mW/pole inverter‐based Gm‐C bandpass filter with automatic frequency tuning
Authors: Zhou Mingzhu , Wang Keping
Published: June 2018

A low‐power Gm‐C filter with the elliptic prototype targeting wireless application of the IEEE 802.15.4 (ZigBee) standard is presented. A modified inverter‐based Gm cell is proposed to increase the current efficiency. Due to the tail current source, this Gm cell also shows better common‐mode rejection and power supply rejection performance than traditional operational transconductance amplifier (OTA) structure. The filter is implemented in a 65 nm CMOS process. It achieves a figure of merit of 0.01 fJ with a power consumption of 0.18 mW/pole from a 1.2 V supply voltage. It provides stopband attenuation better than 40 dB, and an in‐band IIP3 of 9 dBm. An automatic frequency tuning circuit based on sine‐wave PLL method is introduced to compensate for the process variations. The centre frequency and bandwidth can be simultaneously tuned to satisfy the specifications. They are also stable over the process variations with only 2.3% deviation.
A 0.6 V class‐AB rail‐to‐rail CMOS OTA exploiting threshold lowering
Authors: Centurelli F. , Monsurrò P. , Parisi G. , Tommasino P. , Trifiletti A.
Published: June 2018

A class‐AB OTA (operational transconductance amplifier) topology with rail‐to‐rail input common‐mode range is proposed for application in very low‐voltage applications. High efficiency is achieved by reusing transistors both for class‐AB operation and for mirroring the output currents, and a threshold lowering technique is applied to allow supply voltages less than two threshold voltages. Simulations in 40 nm CMOS technology show 41 dB gain at ±0.3 V supply voltage, a unity‐gain frequency of 8.8 MHz on a 5 pF load, class‐AB behaviour and full rail‐to‐rail operation when closed in unity‐gain buffer configuration.
Multi‐level image representation for large‐scale image‐based instance retrieval
Authors: Deng Qili , Wu Shuai , Wen Jie , Xu Yong
Published: June 2018

In recent years, instance‐level‐image retrieval has attracted massive attention. Several researchers proposed that the representations learned by convolutional neural network (CNN) can be used for image retrieval task. In this study, the authors propose an effective feature encoder to extract robust information from CNN. It consists of two main steps: the embedding step and the aggregation step. Moreover, they apply the multi‐task loss function to train their model in order to make the training process more effective. Finally, this study proposes a novel representation policy that encodes feature vectors extracted from different layers to capture both local patterns and semantic concepts from deep CNN. They call this ‘multi‐level‐image representation’, which could further improve the performance. The proposed model is helpful to improve the retrieval performance. For the sake of comprehensively evaluating the performance of their approach, they conducted ablation experiments with various convolutional NN architectures. Furthermore, they apply their approach to a concrete challenge – Alibaba large‐scale search challenge. The results show that their model is effective and competitive.
Self‐regulation in chemical and bio‐engineering materials for intelligent systems
Authors: Huang Zhongyuan , Lei Kewei , He Dan , Xu Yanbin , Williams Jacob , Hu Liu , McNeil Macy , Ruso Juan M. , Liu Zhen , Guo Zhanhu , Wang Zhe
Published: June 2018

Herein, the authors review the self‐regulation system secured by well‐designed hybrid materials, composites, and complex system. As a broad concept, the self‐regulated material/system has been defined in a wide research field and proven to be of great interest for use in a biomedical system, mechanical system, physical system, as the fact of something such as an organisation regulating itself without intervention from external perturbation. Here, they focus on the most recent discoveries of self‐regulation phenomenon and progress in utilising the self‐regulation design. This paper concludes by examining various practical applications of the remarkable materials and systems including manipulation of the oil/water interface, cell out‐layer structure, radical activity, electron energy level, and mechanical structure of nanomaterials. From material science to bioengineering, self‐regulation proves to be not only viable, but increasingly useful in many applications. As part of intelligent engineering, self‐regulatory materials are expected to be more used as integrated intelligent components.
Two‐phase clustering algorithm with density exploring distance measure
Authors: Ma Jingjing , Jiang Xiangming , Gong Maoguo
Published: June 2018

Here, the authors propose a novel two‐phase clustering algorithm with a density exploring distance (DED) measure. In the first phase, the fast global K ‐means clustering algorithm is used to obtain the cluster number and the prototypes. Then, the prototypes of all these clusters and representatives of points belonging to these clusters are regarded as the input data set of the second phase. Afterwards, all the prototypes are clustered according to a DED measure which makes data points locating in the same structure to possess high similarity with each other. In experimental studies, the authors test the proposed algorithm on seven artificial as well as seven UCI data sets. The results demonstrate that the proposed algorithm is flexible to different data distributions and has a stronger ability in clustering data sets with complex non‐convex distribution when compared with the comparison algorithms.
Integrated-light analyses vs. colour-magnitude diagrams
Authors: Ruiz-Lara T. , Gallart C. , Beasley M. , Monelli M. , Bernard E. J. , Battaglia G. , Sánchez-Blázquez P. , Florido E. , Pérez I. , Martín-Navarro I.
Published: June 2018

Context. Most of our knowledge of the stellar component of galaxies is based on the analysis of distant systems and comes from integrated light data. It is important to test whether the results of the star formation histories (SFH) obtained with standard full-spectrum fitting methods are in agreement with those obtained through colour-magnitude diagram (CMD) fitting (usually considered the most reliable approach).

Aims. We compare SFHs recovered from the two techniques in Leo A, a Local Group dwarf galaxy most of whose stars formed during the last 8 Gyrs. This complements our previous findings in a field in the Large Magellanic Cloud bar, where star formation has been in progress since early epochs at varying rates.

Methods. We have used GTC/OSIRIS in long-slit mode to obtain a high-quality integrated light spectrum by scanning a selected region within Leo A, for which a CMD reaching the old main sequence turn-off (oMSTO) is available from HST. We compared the SFH obtained from the two datasets, using state-of-art methods of integrated light (STECKMAP) and resolved stellar population analysis. In the case of the CMD, we computed the SFH both from a deep CMD (observed with HST/ACS) and from a shallower CMD (archival data from HST/WFPC2).

Results. The agreement between the SFHs recovered from the oMSTO CMD and from full spectrum fitting is remarkable, particularly regarding the time evolution of the star formation rate. The overall extremely low metallicity of Leo A is recovered up to the last 2 Gyrs when some discrepancies appear. A relatively high metallicity found for the youngest stars from the integrated data is a recurring feature that might indicate that the current models or synthesis codes should be revised, but that can be significantly mitigated using a more restrictive metallicity range. We thoroughly inspect the robustness of both approaches separately, finding that the subtle differences between them are inherent to the methods themselves. The SFH recovered from the shallow CMD also presents differences with the other two.

Conclusions. Modern full-spectral fitting codes are able to recover both average constant SFHs (LMC case) and SFHs with a dominant fraction of young stellar populations. The analysis of high S/N spectra seems to provide more reliable SFH estimates than that of CMDs not reaching the oMSTO. The comparison presented in this paper needs to be repeated for predominantly old systems, thus assessing the performance of full-spectrum fitting for a full range of SFHs.
Design, calibration and operational error analysis of a heat flux sensor
Authors: Zribi Aymen , Bégot Sylvie , Lanzetta François , Barthès Magali
Published: June 2018

In this paper, we present a gradient based heat flux sensor. It consists of platinum resistances deposited on a glass substrate. The dimensions of are 5 mm × 5 mm × 0.5 mm. The sensor can be embedded in a dedicated housing. The calibration test bench, method, uncertainties and results are presented. This sensor can measure heat fluxes in steady state mode up to 8000 W/m2and can withstand 100 °C. The results were found to be consistent with reference heat fluxes. The operational error caused by the sensor is addressed by numerical parametric studies. The influence of different wall thermal properties is studied. Different radiative and convective conditions are also simulated. Finally, the influence of connecting wires is analyzed. In some specific cases, the sensor does not influence the measurement. In all other cases, correction factors are derived. It is shown that radiative heat transfer and connecting wires can have a strong influence on correction factors.
Numerical investigation of the vibration effect of a flexible membrane on the flow behaviour around a circular cylinder
Authors: Maktouf Nabaouia , Ben Moussa Ali , Turki Saïd
Published: June 2018

Active control of the flow behind a bluff body is obtained by integrating a vibrating membrane. A numerical study has been conducted to investigate the effect of the vibration of a flexible membrane, stuck to the rear side of a circular cylinder, on the global flow parameters such as the Strouhal number, the drag and lift coefficients. The shape of the membrane is evolving as a vibrating chord using a dynamic mesh. The governing equations of 2D and laminar flow have been solved using ANSYS Fluent 16.0 as a solver and the Gambit as a modeler. The motion of the membrane is managed by two parameters: frequency f and amplitude A. The effect of the flexible membrane motion is studied for the range of conditions as 0.1 Hz ≤ f ≤ 6 Hz and 5 × 10−4 m ≤ A ≤ 10−3 m at a fixed Reynolds number, Re = 150. Three different sizes of the flexible membrane have been studied. Results show that a beat phenomenon affects the drag coefficient. The amplitude does not affect significantly the Strouhal number as well as drag and lift coefficients. By increasing the size of the flexible membrane, we show a lift enhancement by a growth rate equal to 39.15% comparing to the uncontrolled case.
Testikulärer Keimzelltumor in Form eines Rhabdomyosarkoms (high grade) bei einem HIV-Infizierten mit Psoriasis vulgaris unter Therapie mit Adalimumab
Authors: Heyne S. , Jahn S. , Meier F. , Herout R. , Beissert S. , Spornraft-Ragaller P.
Published: June 2018

Bei einer HIV-Infektion besteht ein allgemein erhöhtes Tumorrisiko. Im Genitalbereich treten vor allem HPV-assoziierte Karzinome gehäuft auf. Bisher wurden Keimzelltumoren mit somatischer Malignität in Form eines Rhabdomyosarkoms bei HIV-Infektion kaum beschrieben. Im Folgenden stellen wir einen 47-jährigen Patienten mit HIV-Infektion und ausgeprägter Psoriasis vulgaris vor, bei welchem sich unter einer Therapie mit Adalimumab ein testikulärer, nicht-seminomatöser Keimzelltumor mit reifen Teratom-, Dottersacktumoranteilen und somatischer Malignität in Form eines Rhabdomyosarkoms (high grade) im Bereich des rechten Hodens entwickelte. Mit Feststellung der Raumforderung wurde die Therapie mit Adalimumab gestoppt und das Rhabdomyosarkom reseziert. 4 Monate nach Ablatio testis kam es zu einem ausgeprägten Lokalrezidiv mit V. a. eine regionale Weichteilmetastase und V. a. Lymphknotenmetastasen iliacal bds. Es erfolgte eine erneute Resektion und eine adjuvante Chemotherapie mit Epirubicin/Ifosfamid. Ein Einfluss des TNF-Alpha-Blockers Adalimumab auf die Bildung des Rhabdomyosarkoms kann nicht ausgeschlossen werden. Bei HIV-Infektion und gleichzeitiger Therapie mit TNF-Alpha-Blockern ist folglich verstärkt auf ein erhöhtes Tumorrisiko zu achten.
Von der Abschlussarbeit zur Publikation – Erfolgreich publizieren
Authors: Baschung-Pfister Pierrette
Published: June 2018

Wer studiert, krönt sein Studium mit einer Abschlussarbeit zu einem spezifischen Thema. Damit von den Erkenntnissen nicht nur Betreuer und Gutachter erfahren, kann der Studierende die Ergebnisse in einem Journal publizieren. Dafür muss eine wissenschaftliche Arbeit bestimmte Kriterien erfüllen.
Zeiterleben von Kindern und Angehörigen in palliativen Situationen – Die Subjektivität der Zeit
Authors: Schiffers Andrea
Published: June 2018

„Mama, heute sterbe ich“, sagte eine 16-Jährige morgens zu ihrer Mutter in der Endphase ihrer Karzinomerkrankung. Obwohl alle wussten, dass der Tod bevorstand, erschreckte die Klarheit des Satzes. „Doch nicht jetzt!“, dachte die Mutter. Was hier so irritiert, ist uns aus anderen Situationen vertraut. Wie wir Schönes oder Langweiliges erleben, hat mit subjektivem Zeiterleben zu tun.
Psychische Begleiterkrankungen nach Schlaganfall
Authors: Elsner Bernhard , Mehrholz Jan
Published: June 2018

Einer von drei Menschen erfährt im Laufe seines Lebens eine Demenz, einen Schlaganfall oder beides. Neben Menschen mit klinisch prominenten demenziellen
Syndromen interessieren sich Forschung und Gesundheitspolitik seit den letzten Jahren zunehmend für Menschen mit kognitiven Einschränkungen nach Schlaganfall.
Psychische Begleiterkrankungen nach Schlaganfall sind häufig. Die kognitiven Einschränkungen genügen zwar in der Regel nicht den Kriterien einer klinischen
Diagnose, beeinträchtigen aber erheblich die Lebensqualität und können den Therapieverlauf gravierend negativ beeinflussen.
Ich wünsche mir, ernst genommen zu werden
Authors: Mehrholz Katja
Published: June 2018

Die Patientin (Jahrgang 1964) wurde mit einer Dyspnoe in die Rettungsstelle des Krankenhauses eingeliefert. Sie berichtete, dass sie zu diesem Zeitpunkt schon seit 14 Tagen an Luftnot gelitten habe. Der pulmonale Zustand verschlechterte sich rapide, sodass sie beatmungspflichtig wurde. Diagnose: Critical-Illness-Polyneuropathie nach respiratorischer Globalinsuffizienz, Adipositas per magna, Depression. Nach fünf Wochen Krankenhausaufenthalt kam sie in unsere Reha-Klinik.
Multifidus Muscle Size and Symmetry in Ballroom Dancers with and without Low Back Pain
Authors: Smyers Evanson Alyssa , Myrer Joseph , Eggett Dennis , Mitchell Ulrike , Johnson A.
Published: June 2018

The incidence of low back pain (LBP) among elite ballroom dancers is high and understanding associations between muscle morphology and pain may provide insight into treatment or training options. Research has linked multifidus muscle atrophy to LBP in the general and some athletic populations; however, this has not been examined in ballroom dancers. We compared the lumbar multifidus cross-sectional area (CSA) at rest in 57 elite level ballroom dancers (age 23±2.4 years; height, 174±11 cm; mass, 64±10 kg) divided into one of three pain groups, according to their self-reported symptoms, 1) LBP group (n=19), 2) minimal LBP (n=17), and 3) no LBP (n=21). There were no significant difference in demographics between the groups (P>0.05). The LBP group demonstrated significant differences in reported pain and Oswestry Disability Index scores compared to the other two groups. There was no significant difference between groups in multifidus cross-sectional area (P=0.49). Asymmetry was found in all groups with the overall left side being significantly larger than the right (P<0.002). Pain associated with segmental decrease in multifidus CSA was not observed in ballroom dancers with LBP, suggesting other reasons for persistent LBP in ballroom dancers.
Asymmetric and Regiospecific Synthesis of Isotopically Labelled Cyclopropane Fatty Acid (9R,10S)-Dihydrosterculic Acid: Overcoming Spontaneous Protonation During Lithium-Sulfoxide Exchange­
Authors: Shields Samuel , Buist Peter , Manthorpe Jeffrey
Published: June 2018

The total synthesis of isotopically labelled (9R,10S)-dihydro­sterculic acid, a usual cyclopropane fatty acid with biologically relevant toxicity upon desaturation in vivo, is reported. A diastereoselective Corey­–Chaykovsky reaction was employed to form the cyclopropane ring. Rapid quenching of a lithium-sulfoxide exchange was required to achieve the requisite high levels of deuterium incorporation.
Guanidines as Reagents in Proton-Coupled Electron-Transfer Reactions and Redox Catalysts
Authors: Himmel Hans-Jörg
Published: June 2018

Redox-active guanidines are ideal proton-coupled electron-transfer (PCET) reagents, since they combine a high Brønsted basicity with a low and tunable redox potential. In this article, the development of redox-active guanidines (especially guanidino-functionalized aromatics, GFAs) in the last ten years is summarized, and their properties compared to other organic Brønsted bases and organic electron donors. First, some applications in organic chemistry that purely use the redox activity (formation of organic donor–acceptor materials and photochemical reductive C–C coupling reactions) are presented. Then, reactions that involve both proton and electron transfer are reviewed. In stoichiometric reactions, redox-active guanidines are used for the dehydrogenative coupling of thiols and phosphanes. The first redox catalytic applications are discussed, using dioxygen as green oxidizing reagent.

1 Introduction

2 Redox-Active Amines and Guanidines

3 Brønsted Basicity of Amines and Guanidines

4 Variations of GFA Compounds

5 GFA Compounds in Organic Donor–Acceptor Materials and as Reducing Reagents in Organic Synthesis

6 Stoichiometric Dehydrogenative Coupling Reactions with Redox-Active Guanidines

7 Guanidines as Redox Catalysts

8 Conclusions and Outlook
The Thrombo-embolic Disease in Pre-eclampsia
Authors: Zilliacus Harry
Published: June 2018

On the basis von 19756 obstetrical cases reviewed with regard to the frequency of thrombo-embolism it was found that post partal thrombo-embolism occurs about four times more frequently in late toxemia of pregnancy than in non preeclamptic obstetrical cases. There were 95 cases of puerperal thrombo-embolism (58 in superficial and 37 in deep seated veins of the leg) among the 2077 cases of late toxemia of pregnancy, which means a frequency of 4.6 per cent against a total frequency of thrombo-embolism of 1.2 per cent among all the obstetrical cases reviewed. Possible causes for a thrombotic process in pre-eclampsia are dicussed: placental thromboplastins, high concentration of plasma fibrinogen and other coagulation factors, aggregation and sedimentation of erythrocytes, retardation of the venous flow.

Of the anticoagulants heparin is recommended as the most suitable agent in prophylactic treatment of thrombosis in late toxemia of pregnancy.
Über die Aktivitätssteigerung der Thrombokinase in Blutgefäßwänden durch Hyaluronidase
Authors: Witte Siegfried , Bressel Dietrich
Published: June 2018

Es wurde der Einfluß von Hyaluronidase auf die Gewebsthrombokinase in Extrakten von menschlichen Blutgefäßen untersucht. Die lagerungsstabile Thrombokinaseaktivität aus Aorta wird durch Hyaluronidase nicht verändert. Dagegen erfährt die Thrombokinase aus Venenwand, die meist weniger aktiv und lagerungslabiler ist, durch Inkubation mit Hyaluronidase eine signifikante Aktivitätssteigerung. Daraus ergeben sich Zusammenhänge zwischen Gewebsthrombokinase und dem Hyaluronsäure-Hyaluronidase-System in der Blutgefäßwand, deren pathophysiologische Bedeutung diskutiert wird.
On the Purification and Conversion of Human Prothrombin
Authors: Streuli F
Published: June 2018

A combined chemical and immunological method for the purification of human prothrombin is described. After isoelectric precipitation a purified prothrombin is obtained. Its activity per mg of protein is 210 folds higher than that of plasma. This prothrombin and the prothrombin purified on a BaSO4 column are not converted into thrombin in a 25% sodium-citrate solution. No thrombin is formed by the addition of calcium ions and brain thromboplastin. For its conversion, a complete clotting system (extrinsic or intrinsic) is necessary. Our experiments present no evidence for the hypothesis that Factors VII, IX, PPA and Stuart-Prower are prothrombin derivatives.

The conversion of prothrombin to thrombin by means of isolated blood thromboplastin is studied. The results still do not permit one to decide whether the reaction is stoichiometric or enzymatic.
Some Properties of a Reaction Mechanism Analogous to Thrombin Formation
Authors: Surgenor Douglas Mac N
Published: June 2018

Using an analog computor, the behavior with respect to time of a model chemical reaction mechanism has been studied. This mechanism consists of a consecutive series of reactions, the product of which corresponds to a prothrombin activator that acts enzymatically upon prothrombin. The striking resemblance in behavior between the model mechanism and the natural system strengthens current concepts of prothrombin activator formation.
Über die Retraktion des Blutgerinnsels
Authors: Benthaus J
Published: June 2018

Nach kritischer Betrachtung der bekannten Methoden zur Bestimmung der Retraktion des Blutgerinnsels wird die für die vorliegenden Untersuchungen angewandte Arbeitsweise geschildert. Sie eignet sich zur quantitativen Messung des bei der Retraktion abgesonderten Serums. — Der Ablauf der Retraktion als Bewegungsvorgang läßt sich mit dieser Methode genauer darstellen. — Die Gerinnungsfaktoren (Thrombokinase, Kalzium, Thrombin, Heparin) haben nach beendigter Fibrinbildung keinen Einfluß mehr auf die Retraktion. — Der Einfluß von Temperatur, osmotischem Druck und Wasserstoffionenkonzentration wird nachgeprüft. — Ausreichende Zahl und Funktionstüchtigkeit der Plättchen sind die unbedingte Voraussetzung für eine normale Retraktion. — Einige ausgewählte Theorien über das Wesen der Retraktion werden besprochen. — Untersuchungen mit histologischer Technik führen zu einer Vorstellung vom Mechanismus der Retraktion: Konsistenzveränderung des Fibrins durch die Einwirkung der Plättchen ermöglicht das Konfluieren des Fibrins mit der Plättchensubstanz.
The Fate of Factor VII and Stuart Factor During the Clotting of Normal Blood
Authors: Johnston Charles L , Ferguson John H , O’Hanlon Frieda A , Black W. L
Published: June 2018

Studies have been presented, utilizing factor specific assays, to show that Factor VII and Stuart factor behave differently during the clotting of normal blood. Stuart factor was neither consumed nor activated during clotting. In contrast, Factor VII was “activated” so that serum contained 2V2 to 3 times the plasma concentration of the factor. Marked rate changes occurred in the Factor VII activation curves when the sample incubation temperature was changed. The data obtained suggested that the optimum temperature for Factor VII activation may be at or near 18° C. Previous “consumption” data for “Factor VII” obtained by assays sensitive to changes in both Stuart factor and Factor VII have been validated, since the concentration of Stuart factor does not change during clotting.
Differentiation of the Factor VII Complex
Authors: Bachmann F , Duckert F , Geiger M , Baer P , Koller F
Published: June 2018

A factor recently described and for which the designation Stuart-Prower Factor is proposed, was investigated. It is detected by the usual Factor VII assay but differs from this factor (Matching experiments with plasma and serum of Owren’s Factor VII deficient patient). Stuart-Prower factor is necessary for the conversion prothrombin-thrombin with tissue thromboplastin as well as for the formation of blood thromboplastin. Therefore lack of Stuart-Prower factor produces abnormal Quick’s prothrombin time (not normalized with Russell’s viper venom [Stypven]), and also abnormal prothrombin consumption, abnormal recalcification time and abnormal thromboplastin generation with serum. Matching experiments with plasma and serum of the patients of Graham and Hougie, Telfer Denson and Wright, and Beaumont and Bernard show that we are dealing with the same defect. Physiological and physico-chemical properties are indicated. The possible relationship between Stuart-Prower factor and Factor X is discussed. A critical review with 59 cases of the so-called Factor VII deficiency is given. Investigation of the family of our patient Delia B. indicates that the mode of inheritance is an intermediate autosomal one.
Rationale for In-Neonatal Intensive Care Unit Administration of Live, Attenuated Rotavirus Vaccination
Authors: Briggs-Steinberg Courtney , Shah Shetal
Published: June 2018

Rotavirus is the most common nonseasonal vaccine preventable illness. Despite increased severity of rotaviral illness in early infancy, most neonatal intensive care units (NICU) do not administer rotavirus vaccination either during the NICU stay at age of eligibility or at discharge as the Advisory Committee on Immunization Practices recommends. In this commentary, we review the rationale for the administration of rotavirus vaccination to premature infants. Further, we outline data supporting vaccine administration at chronologic age while still admitted to the NICU.
The Effect of Wearing White Coats on Patients' Appreciation of Physician Communication during Postpartum Rounds: A Randomized Controlled Trial
Authors: Spencer Nicholas , Abdelwahab Mahmoud , Zambrano Gabriela , Saoud Fawzi , Jelliffe Katherine , Olson Gayle , Munn Mary , Saade George , Costantine Maged , La Rosa Mauricio
Published: June 2018

Objective Wearing a white coat (WC) has been associated with risk of colonization and transmission of resistant pathogens. Also, studies have shown that physicians' attire in general affects patients' confidence in their physician and the patient–physician relationship. Our objective is to evaluate the hypothesis that not wearing a WC during physician postpartum rounds does not affect patient–physician communication scores.

Materials and Methods This is an unblinded, randomized, parallel arms, controlled trial of postpartum women at a single university hospital. Women were randomly assigned to having their postpartum physicians' team wear a WC or not (no-WC) during rounds. Our primary outcome was “patient–physician communication” score. Univariable and multivariable analysis were used where appropriate.

Results One hundred and seventy-eight patients were enrolled (87 in WC and 91 in no-WC groups). Note that 40.4% of patients did not remember whether the physicians wore a WC or not. There was no difference in the primary outcome (p = 0.64) even after adjusting for possible confounders.

Conclusion Not wearing a WC during postpartum rounds did not affect the patient–physician communication or patient satisfaction scores. In the setting of prior reports showing a risk of WC pathogen transmission between patients, our findings cannot support the routine wearing of WCs during postpartum rounds.
Linear least-squares method for global luminescent oil film skin friction field analysis
Authors: Lee Taekjin , Nonomura Taku , Asai Keisuke , Liu Tianshu
Published: June 2018

A data analysis method based on the linear least-squares (LLS) method was developed for the extraction of high-resolution skin friction fields from global luminescent oil film (GLOF) visualization images of a surface in an aerodynamic flow. In this method, the oil film thickness distribution and its spatiotemporal development are measured by detecting the luminescence intensity of the thin oil film. From the resulting set of GLOF images, the thin oil film equation is solved to obtain an ensemble-averaged (steady) skin friction field as an inverse problem. In this paper, the formulation of a discrete linear system of equations for the LLS method is described, and an error analysis is given to identify the main error sources and the relevant parameters. Simulations were conducted to evaluate the accuracy of the LLS method and the effects of the image patterns, image noise, and sample numbers on the results in comparison with the previous snapshot-solution-averaging (SSA) method. An experimental case is shown to enable the comparison of the results obtained using conventional oil flow visualization and those obtained using both the LLS and SSA methods. The overall results show that the LLS method is more reliable than the SSA method and the LLS method can yield a more detailed skin friction topology in an objective way.
Correlation between audible noise and corona current generated by AC corona discharge in time and frequency domains
Authors: Li Xuebao , Wang Jing , Li Yinfei , Zhang Qian , Lu Tiebing , Cui Xiang
Published: June 2018

Corona-generated audible noise is induced by the collisions between space charges and air molecules. It has been proven that there is a close correlation between audible noise and corona current from DC corona discharge. Analysis on the correlation between audible noise and corona current can promote the cognition of the generation mechanism of corona discharge. In this paper, time-domain waveforms of AC corona-generated audible noise and corona current are measured simultaneously. The one-to-one relationship between sound pressure pulses and corona current pulses can be found and is used to remove the interferences from background noise. After the interferences are removed, the linear correlated relationships between sound pressure pulse amplitude and corona current pulse amplitude are obtained through statistical analysis. Besides, frequency components at the harmonics of power frequency (50 Hz) can be found both in the frequency spectrums of audible noise and corona current through frequency analysis. Furthermore, the self-correlation relationships between harmonic components below 400 Hz with the 50 Hz component are analyzed for audible noise and corona current and corresponding empirical formulas are proposed to calculate the harmonic components based on the 50 Hz component. Finally, based on the AC corona discharge process and generation mechanism of audible noise and corona current, the correlation between audible noise and corona current in time domain and frequency domain are interpreted qualitatively. Besides, with the aid of analytical expressions of periodic square waves, sound pressure pulses, and corona current pulses, the modulation effects from the AC voltage on the pulse trains are used to interpret the generation of the harmonic components of audible noise and corona current.
Experimental setup for the study of resonant inelastic X-ray scattering of organometallic complexes in gas phase
Authors: Ismail I. , Guillemin R. , Marchenko T. , Travnikova O. , Ablett J. M. , Rueff J.-P. , Piancastelli M.-N. , Simon M. , Journel L.
Published: June 2018

A new setup has been designed and built to study organometallic complexes in gas phase at the third-generation Synchrotron radiation sources. This setup consists of a new homemade computer-controlled gas cell that allows us to sublimate solid samples by accurately controlling the temperature. This cell has been developed to be a part of the high-resolution X-ray emission spectrometer permanently installed at the GALAXIES beamline of the French National Synchrotron Facility SOLEIL. To illustrate the capabilities of the setup, the cell has been successfully used to record high-resolution Kα emission spectra of gas-phase ferrocene Fe(C5H5)2 and to characterize their dependence with the excitation energy. This will allow to extend resonant X-ray emission to different organometallic molecules.
Size-independent neural networks based first-principles method for accurate prediction of heat of formation of fuels
Authors: Yang GuanYa , Wu Jiang , Chen ShuGuang , Zhou WeiJun , Sun Jian , Chen GuanHua
Published: June 2018

Neural network-based first-principles method for predicting heat of formation (HOF) was previously demonstrated to be able to achieve chemical accuracy in a broad spectrum of target molecules [L. H. Hu et al., J. Chem. Phys. 119, 11501 (2003)]. However, its accuracy deteriorates with the increase in molecular size. A closer inspection reveals a systematic correlation between the prediction error and the molecular size, which appears correctable by further statistical analysis, calling for a more sophisticated machine learning algorithm. Despite the apparent difference between simple and complex molecules, all the essential physical information is already present in a carefully selected set of small molecule representatives. A model that can capture the fundamental physics would be able to predict large and complex molecules from information extracted only from a small molecules database. To this end, a size-independent, multi-step multi-variable linear regression-neural network–B3LYP method is developed in this work, which successfully improves the overall prediction accuracy by training with smaller molecules only. And in particular, the calculation errors for larger molecules are drastically reduced to the same magnitudes as those of the smaller molecules. Specifically, the method is based on a 164-molecule database that consists of molecules made of hydrogen and carbon elements. 4 molecular descriptors were selected to encode molecule’s characteristics, among which raw HOF calculated from B3LYP and the molecular size are also included. Upon the size-independent machine learning correction, the mean absolute deviation (MAD) of the B3LYP/6-311+G(3df,2p)-calculated HOF is reduced from 16.58 to 1.43 kcal/mol and from 17.33 to 1.69 kcal/mol for the training and testing sets (small molecules), respectively. Furthermore, the MAD of the testing set (large molecules) is reduced from 28.75 to 1.67 kcal/mol.
A Bayesian nonparametric approach to dynamical noise reduction
Authors: Kaloudis Konstantinos , Hatjispyros Spyridon J.
Published: June 2018

We propose a Bayesian nonparametric approach for the noise reduction of a given chaotic time series contaminated by dynamical noise, based on Markov Chain Monte Carlo methods. The underlying unknown noise process (possibly) exhibits heavy tailed behavior. We introduce the Dynamic Noise Reduction Replicator model with which we reconstruct the unknown dynamic equations and in parallel we replicate the dynamics under reduced noise level dynamical perturbations. The dynamic noise reduction procedure is demonstrated specifically in the case of polynomial maps. Simulations based on synthetic time series are presented.
Reversal time of jump-noise magnetization dynamics in nanomagnets via Monte Carlo simulations
Authors: Parthasarathy Arun , Rakheja Shaloo
Published: June 2018

The jump-noise is a nonhomogeneous Poisson process which models thermal effects in magnetization dynamics, with special applications in low temperature escape rate phenomena. In this work, we develop improved numerical methods for Monte Carlo simulation of the jump-noise dynamics and validate the method by comparing the stationary distribution obtained empirically against the Boltzmann distribution. In accordance with the Néel-Brown theory, the jump-noise dynamics display an exponential relaxation toward equilibrium with a characteristic reversal time, which we extract for nanomagnets with uniaxial and cubic anisotropy. We relate the jump-noise dynamics to the equivalent Landau-Lifshitz dynamics up to second order correction for a general energy landscape and obtain the analogous Néel-Brown theory's solution of the reversal time. We find that the reversal time of jump-noise dynamics is characterized by Néel-Brown theory's solution at the energy saddle point for small noise. For large noise, the magnetization reversal due to jump-noise dynamics phenomenologically represents macroscopic tunneling of magnetization.
Optical properties of lonsdaleite silicon nanowires: A promising material for optoelectronic applications
Authors: Dixit Saurabh , Shukla A. K.
Published: June 2018

Lonsdaleite silicon has exhibited a wealth of fascinating properties and is known to have photoluminescence at room temperature. Several researchers have reported the limitations of diamond cubic silicon in the area of optoelectronic devices due to its indirect band gap. Therefore, different phases of silicon are investigated worldwide for the substitute of diamond silicon to overcome its limitation. Recently, it is suggested that lonsdaleite silicon nanowires (SiNWs) can be used as a potential material for optoelectronic applications. Therefore, the optical properties of lonsdaleite silicon nanowires are investigated here by Raman spectroscopy, UV-vis absorption spectroscopy and photoluminescence spectroscopy. Phonon dispersion curve, which has been computed using density functional calculations, is utilized to study the Raman modes of lonsdaleite silicon nanowires. The absorption coefficient of lonsdaleite silicon nanowires shows a remarkable enhancement in comparison with that of diamond structured SiNWs. Furthermore, greenish-yellow photoluminescence is also observed here from lonsdaleite silicon nanowires.