bluuebunny/crossref_metadata_2025 huggingface dataset:
IMMUNE DYSREGULATION IN AUTOIMMUNE HEPATITIS: THE ROLE OF AUTOANTIBODIES, T-REG CELLS, AND NOVEL THERAPEUTIC APPROACHES
Authors: Hladkykh F.V.
Published: November 2024

Introduction. The liver is a crucial immunological tolerogenic organ with a unique ability to generate effective immune responses against hepatotropic pathogens while maintaining both local and systemic immune tolerance to self and foreign antigens. Autoimmune hepatitis (AIH) is an immune-mediated inflammatory liver disease caused by the loss of tolerance to liver-specific antigens, leading to autoimmune liver damage.Aim – to summarize current knowledge on the immunopathogenesis of AIH based on information from open sources.Material and methods. The selection of publications was conducted using databases such as PubMed, Clinical Key Elsevier, Cochrane Library, eBook Business Collection, and Google Scholar, which covered information on the immunopathogenesis of AIH. Literature search was performed using keywords: autoimmune diseases, autoimmune hepatitis, Kupffer cells, autoantibodies to liver microsomal antibodies, and mesenchymal stem cells.Research results. Liver immune regulation is mediated by unique cell populations, including T-reg cells, Kupffer cells, and NK cells, which interact to maintain immune tolerance and regulate inflammation. Deficiency or dysfunction of T-reg cells, along with the activation of Th17 cells, contribute to the development of inflammatory processes and autoimmune liver damage. The quantitative and qualitative composition of immune cells in the liver differs significantly from that in secondary lymphoid organs, such as lymph nodes, spleen, or peripheral blood. The CD8+/CD4+ ratio (3.5:1) of liver T cells contrasts with the 1:2 ratio observed in peripheral blood, lymph nodes, and spleen.Conclusions. AIH is a complex disease with a multifaceted immunopathogenesis. T-reg and MSC-based therapies show promising results in clinical trials; however, further research is needed to optimize these methods and ensure their safe and effective application.
EVALUATION OF THE FUNCTIONAL STATE OF KIDNEYS IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION BASED ON THE DETERMINATION OF CREATININE AND CYSTATIN C LEVELS
Authors: Broniuk A.V. , Rasputina L.V.
Published: November 2024

Aim – to evaluate the functional state of kidneys, glomerular filtration rate based on the determination of creatinine and Cystatin C in STEMI patients undergoing urgent revascularization.Methods and materials. The study included 286 patients with acute myocardial infarction and ST-elevation myocardial infarction (STEMI). Among the examined persons, 202 (70.6%) were men and 84 (29.4%) were women, with an average age of (62.8±9.8) years.Research results. The GFR calculated by the CKD-EPI formula in the examined group of STEMI patients ranged from 15.6 to 87.4 and averaged 51.0±14.3 ml/min∙m2.7. The value of the calculated GFR according to the CKD-EPI Cystatin C formula ranged from 11.1 to 88.1 and averaged 45.7±13.7 ml/min/1.73 m2. The non-parametric Spearman rank correlation analysis showed a high direct correlation between the values of GFR calculated by different formulas (CKD-EPI and CKD-EPI Cystatin C) - R=0.81; p<0.0001. Using the linear regression method, a formula was derived for the conditional calculation of GFR value according to CKD-EPI Cystatin C = 4.15 + GFR value according to CKD-EPI 0.814. Regression coefficient R2 = 0.84 (Fisher's correlation coefficient - F = 728.34 at the proper level = 1.28), p < 0.000001.Conclusions. Determination of GFR based on Cystatin C demonstrates lower rates in both men and women. A decrease in estimated GFR was related to older age and female gender.
FREQUENCY OF INFECTIOUS AND NON-INFECTIOUS DISEASES DURING THE WAR IN UKRAINE BASED ON SOME PRIMARY MEDICAL CARE UNITS' DATA IN THE CHERNIVTSI REGION
Authors: Sydorchuk L.P. , Sokolenko M.O. , Lopushniak H.Ya. , Vyksych R.R. , Tkachuk A.V. , Gavryliuk Ye.S. , Pogynaiko A.I.
Published: November 2024

Aim – to investigate the impact of the war in Ukraine and COVID-19 on the frequency of infectious (COVID-19, tuberculosis) and non-infectious diseases (hypertension (AH), diabetes mellitus (DM), obesity, thyroid pathology, chronic kidney disease (CKD)) according to data from primary health care units in Chernivtsi region..Material and methods. The statistical reports of Communal Non-commercial Enterprises (CNEs) "Kitsman Center of Primary Medical Care" of the Kitsman District Council and "City Polyclinic No. 1" of the Chernivtsi City Council for the years 2019-2023 with the number of observed population subject to medical care - 36,508 and 58,500, respectively, were analyzed.Results. During the COVID-19 pandemic (2021-2022), a surge in the incidence of tuberculosis was observed in separate communities, with an almost 7% increase per 100,000 residents in the Chernivtsi region as a whole (in 2022-2023), caused, in our opinion, by the war and an increased population migration. During the period of the COVID-19 pandemic and with the beginning of the full-scale invasion of the russian federation on the territory of Ukraine, a strict trend in the incidence of DM increase (mainly non-insulin-dependent) was established. The frequency of obesity in women increased as well by 17.5%, while in men, on the contrary, it decreased – by 17.42%. The frequency of diffuse goiter in the structure of thyroid diseases decreased by 3%, with a slight elevation in autoimmune thyroiditis.Conclusion. An obvious dependence of changes in the incidence of CKD and hypertension in linkage with the COVID-19 pandemic and the war in Ukraine was not established in the analyzed communities.
THE EFFECT OF EMPAGLIFLOZIN AND RANOLAZINE ON THE DYNAMICS OF STRUCTURAL AND FUNCTIONAL PARAMETERS OF THE HEART AND LEVELS OF BIOMARKERS NT-proBNP AND SOLUBLE (s)ST-2 IN PATIENTS WITH ATRIAL FIBRILLATION AND HEART FAILURE
Authors: Kulaiets N.M. , Seredyuk V.N.
Published: November 2024

Atrial fibrillation (AF) is the most common long-term arrhythmia worldwide and has a strong association with heart failure (HF).Aim. To investigate the effect of empagliflozin and ranolazine in addition to standard therapy on the dynamics of structural and functional parameters of the heart and levels of biomarkers NT-proBNP and soluble (s)ST-2 in patients with atrial fibrillation and heart failure.Materials and Methods. We examined 300 patients aged 45-65 years. All patients were divided into groups: Group I - patients with HF without AF (n=150). Group II - patients with HF and AF (permanent form) (n=150). Group of 136 practically healthy individuals. All patients underwent clinical examination, echocardiography (Echo), determination of NT-proBNP and (s)ST-2 levels by enzyme-linked immunosorbent assay.Results. The dynamics of parameters of the LV in the main group was more significant compared to the control group (p<0.05). After treatment, the concentration of circulating NT-ProBNP in the control group decreased by an average of 26.2% (p<0.05), and in the main group of patients - by 15.9% (p<0.05). As for the blood levels of the (s)ST-2 biomarker, after treatment in the control group there was an average decrease of 13.1% (p<0.05) compared with the dynamics in the main group of patients - by 38.8% (p<0.05).Conclusions. The use of INSKTG-2 empagliflozin against the background of standard therapy of heart failure reduction of myocardial remodelling and increase ejection fraction. Complex treatment with empagliflozin and ranolazine as INZCTG-2 helps to reduce the level of NT-ProBNP and (s)ST-2 in the blood serum.
О КРИТЕРИИ РОБИНА
Authors: Ахмадуллин Роберт
Published: November 2024

Получены достаточные условия выполнения критерия Робина. Найдены необходимые условия минимальности арифметической функции N/σ(N) при фиксированном числе сомножителей числа N.
Electoral discourse: women as represented by Russian and Colombian mass media
Authors: Ruiz M. , Boguslavskaya V.V.
Published: November 2024

The authors analyse the linguistic strategies modern mass media use when writing about female politicians. Comparison of media discourses in Colombian and Russian media is made by means of interpretive, contextual. discourse and content analysis. The main aim of the study is to identify how the mass media view the role of women in politics and to what extent it is affected by the culture and mentality of the society of a given country. Based on Western European research, three linguistic strategies used by the mass media in the field of “women in politics” were dealt with. As a result of comparing Russian and Columbian media discourses the intensive use of these three strategies in the mass media discourse was identified. Exclusion strategy means that the political power that women have is delegated to them (by men). Invisibility strategy implies the use of a metaphor or catachreza (trope or stylistic error, incorrect or unusual use of word combinations with incompatible literal lexical meanings). The presence of a man as the main co-hero is a determining factor or an integral reference to the political activities of women. Caricature strategy implies description of political actions of women satirically, as caricature, as a ridiculous imitation. Ridicule, derogatory forms of address (derived from one's own name or a diminutive form of a name, reflecting the logic of underestimation) lead to a decline in status. The current media discourse broadcasts the idea that women in politics are isolated cases, exceptions, explained primarily by their personal, political or professional relations with men. Descriptions of women's political activities is full of with stereotypes, prejudices and preconceived notions. Colombian media discourse shows a steady trend towards the use of puns in the linguistic representation of women politicians while Russian mass media tend to use caricature strategies in positioning women in politics. The media discourse of both countries predominantly views women as actors in politics, as subjects that, by their very nature, cannot belong to politics.
Elements of music journalism in socio-political media
Authors: Sinegubova K.V. , Davydova T.A.
Published: November 2024

The article is devoted to the publications of musical subjects in the socio-political newspaper “Novaya Gazeta” (New Gazette). The relevance of the topic is due to the unstable position of music journalism and the tendency to socio-political and musical-critical media texts hybridization. A review of studies on the specifics and status of music journalism in the modern world shows that music journalism tends to reach a wider audience, but in some cases, this provides to simplification and decreases the quality of the text. This paper considers two alternatives of publications on musical topics in the socio-political media. The journalists mainly focus either on enlightened music lovers or on the unenlightened ones, depending on the information flow. In the first case, the central place in the media text is occupied by a piece of music or a musical event, so these publications can be attributed to music journalism. The authors of these materials address rather complex issues and little-known events, but the choice of linguistic and stylistic means in the publications makes them accessible to unenlightened music lovers. In the materials of the second group the actual musical component is less significant, the socio-political significance of a musical event or work comes to the fore. The publications have place on the verge of musical and socio-political journalism and, as a result, address to a wide range of readers.
Pengaruh penambahan pati beras ketan putih pada bahan cetak alginat terhadap stabilitas dimensi hasil cetakan
Authors: Wijaya Eko , Putranti Dwi Tjahyaning
Published: November 2024

pendahuluan: Bahan cetak alginat merupakan bahan cetak yang sering digunakan di bidang kedokteran gigi dan dapat mengalami perubahan dimensi akibat proses sineresis dan imbibisi yang dapat menyebabkan distorsi hasil cetakan. Untuk mencegah terjadinya perubahan dimensi, maka dilakukan penambahan bahan alami seperti pati beras ketan putih pada bahan cetak alginat. Penelitian ini bertujuan untuk menganalisis perbedaan efek penambahan pati beras ketan putih konsentrasi 40%, 50%, dan 60% pada bahan cetak alginat setelah 5, 10 dan 15 menit pencetakan terhadap stabilitas dimensi hasil cetakan alginat. Metode: Rancangan penelitian ini yaitu eksperimental laboratoris. Sampel yang digunakan adalah hasil cetakan alginat yang diisi gipsum tipe III yang diperoleh dari model induk cincin dengan ukuran diameter dalam 12,55 mm dan tinggi 19 mm. Jumlah sampel yang digunakan sebanyak 60 sampel yang terdiri dari 12 kelompok perlakuan. Sampel diukur menggunakan kaliper digital kemudian dianalisis dengan uji Anova satu arah dan dilanjutkan dengan uji LSD (Least Significance Difference). Hasil: Hasil uji Anova satu arah menunjukkan ada pengaruh (p<0,05)  penambahan pati beras ketan putih konsentrasi 40, 50, dan 60% setelah 5 menit pencetakan (A1,  B1.1, B1.2, B1.3) dengan nilai p=0,043 ,setelah 10 menit pencetakan (A2, B2.1, B2.2, B2.3) dengan nilai p=0,0001, dan setelah 15 menit pencetakan (A3, B3.1, B3.2, B3.3) dengan nilai p=0,011. Hasil uji LSD menunjukkan ada perbedaan pengaruh signifikan pada seluruh kelompok dengan nilai (p<0,05). Simpulan: Penambahan pati beras ketan putih konsentrasi 40, 50, dan 60% pada bahan cetak alginat memiliki pengaruh terhadap stabilitas dimensi hasil cetakan dan penambahan pati beras ketan putih 50% menghasilkan stabilitas dimensi hasil cetakan terbaik.
Two decades of population change in Saudi Arabia: Exploring effective redistribution strategies
Authors: Alhamoudi Abdullah Mazen , Salam Asharaf Abdul
Published: November 2024

Census 2022 of Saudi Arabia was released recently, with 12 years of intercensal interval. Although it appeared provisional having no reports similar to the 2010 census, efforts to analyze, interpret, disseminate, and discuss were essential for building structures and systems at par with demographic trends and patterns. An analysis was carried out with this census data compared to 2004 and 2010 to track population change—demographic pace, trends, and patterns—over the two decades. Data from all three censuses were analyzed with conventional demographic techniques. A reduction in growth was observed with a declining percentage of the childhood population but with an expanding percentage of the adults (working age) indicating a demographic dividend resulted, mostly, from fertility decline. An aging trend established by the previous censuses was lost, recently: the constriction of the pyramid of 2010 was changed to a different shape. Not only the percentage distribution trends were uneven but also the age-based indices. Thus, these trends revealed a demographic difference to an extent, that demands standardized reports, uniform procedures for the data collection and compilation, and geographic distribution equations. The increasing concentration in urban centers of major administrative areas—Al-Riyadh, Makkah Al-Mokarramah, and the Eastern Region demand redistribution policies. Self-contained townships appear as a strategic option in population redistribution, guaranteeing quality standards and lifestyle.
Process model for multifactorial characteristics of the sense of place in the case of Budapest (Hungary) District VII
Authors: Molnár-Csomós Ilona
Published: November 2024

The existence of residential well-being of the locals in the sense of equilibrium-state is a competitive advantage for tourism in a given destination. The rise of overtourism could jeopardize this equilibrium and ultimately the effectiveness of tourism in a vulnerable destination. The research question of the study aimed to answer: what are the spiral dynamics of the multifactorial characteristics of the sense of place that can be mapped under the influence of overtourism. Answering the question draws attention to the sense of place—which can be interpreted as a synonym for local character—of the issues of overtourism and residential well-being. Mapping the mechanism of action of the multifactorial characteristic of locality can help to identify non-supportive functions, to pinpoint the balance point for moving towards a supportive quality, and to answer the “how yes” questions at individual, local and collective levels. The answer to the research question is the result of concluding three district-specific sub-questions. The assessment of the results was based on the content analysis of 251 posts (2017–2021) in the local public Facebook group (supplemented by a questionnaire survey of local residents (2022), 30 in-depth interviews with experts and residents (2022) conducted as part of the cross-sectional research, and 10 additional in-depth interviews with residents (2024) conducted for the last sub-question. The flowchart showing the current state of the district along a negative spiral dynamic, the possibility to turn it in a positive direction, and the mind-map-like summary of local, individual and collective mitigation and solution alternatives supporting the change of direction can be considered as a novel scientific result.
The challenges in the utilization of marine genetic resources in national and international jurisdictions from a legal perspective
Authors: Arévalo García Jorge Gabriel , Hernández Trujillo Sergio
Published: November 2024

This article examines the legal challenges associated with the utilization of marine genetic resources (MGR) at both the national level and beyond national jurisdiction (BBNJ). The legal challenges addressed are as follows: 1) MGR are located across various jurisdictions, encompassing both national and international domains. The analysis starts with an overview of the international regulations that govern the utilization of genetic resources (GR) and their influence on national legislation. It emphasizes the principle of state sovereignty over natural resources while defining MGR and determining ownership; 2) It further highlights the intersection of national and international laws, particularly in transboundary contexts and within Indigenous and Afro-descendant peoples (IADP) territories, analyzing how these regulations are interpreted and applied in such scenarios; 3) The legal challenges related to the use of MGR in international waters are examined. Special emphasis is placed on the recent United Nations (UN) Agreement concerning this issue. This includes an analysis of its impact and specific provisions related to the utilization of MGR, such as the quantity to be collected, the methodology employed, collection sites, among others. The article concludes by asserting that the equitable distribution of benefits from the use of GR should begin at the earliest stages of access to these resources, including project planning and sample collection, rather than being delayed until the patenting and commercialization phases. Early benefit-sharing is essential for promoting fairness and equity in the use of MGR.
Carbon dioxide capture in large-scale CCGT power plant from flue gases obtained from various fuel mixtures
Authors: Subramanian Navaneethan , Madejski Paweł
Published: November 2024

In this study, the thermodynamic analysis of a combined cycle gas turbine integrated with post-combustion carbon capture and storage using the solvent method is performed. The syngas obtained from the gasification of sewage sludge is mixed with methane and nitrogen-rich natural gas fuels at different proportions, used in the gas turbine, and the properties of fuel and flue gases are analyzed. The flue gas obtained from the fuel mixture is passed through the post-combustion carbon capture and storage at various load conditions to assess the heat and electricity required for the carbon capture process. The solvent used for the carbon capture from flue gases enables CO2 capture with the high efficiency of 90%. With the calculated results, the load conditions of flue gas using fuel mixtures are identified, which reduces the heat and power demand of post-combustion carbon capture and storage and provides the possibility to achieve neutral emission. The impact of selected operating conditions of post-combustion carbon capture and storage on the CO2 emission reduction process and on the power plant performances is investigated. Considering the factors of electricity generation, energy efficiency, heat supply to the consumers, operating load of post-combustion carbon cap-ture and storage and CO2 emission, the 50% mixture of syngas with both fuels performs better. Also, the use of a mixture of 2-amino-2methyl-1-propanol and piperazine with reboiler duty 3.7 MJ/kgCO2 in post-combustion carbon capture and storage slightly enhanced the performance of the power plant compared to the use of monoethanolamine with reboiler duty 3.8 MJ/kgCO2.
Verhandeln um des Friedens willen. Der Mythos vom Hermesstab
Authors: Rüegger Hans-Ulrich
Published: November 2024

Bei einem Konflikt um des Friedens willen zu verhandeln, ist eine delikate Aufgabe. Eine mythische Erzählung vom Hermesstab, wie sie in der Astronomia des Hyginus überliefert ist, kann dazu anregen, über die Lösung eines Streites nachzudenken, die vom Zwist über Verhandlungen zum Frieden führt. Von diesem hermeneutischen Interesse ist die Studie geleitet. Der Tauschhandel zwischen zwei Götterbrüdern, von dem schon ein homerischer Hymnus berichtet, ist bei Hyginus dadurch motiviert, dass Merkur sich von seinem Bruder Apollo wünscht, er möge ihm verzeihen.
Nach einigen kulturgeschichtlichen Hinweisen zur Bedeutung des Hermes- oder Heroldsstabs lese ich zwei Erzählungen aus den Sternbildsagen des Hyginus und skizziere einige Gedanken zu Momenten der Konfliktlösung, die hierin zu entdecken sind.
Friedens- und Kriegsreden der Herrscher Constantius II. (354) und Julian (360) bei Kaiseraugst
Authors: Hächler Nikolas
Published: November 2024

Der Historiograph Ammianus Marcellinus berichtet, dass die Kaiser Constantius II. 354 und Julian 360 vor dem Heer beim heutigen Kaiseraugst Reden hielten, in denen sie den Truppen ihre strategischen Überlegungen im Umgang mit äusseren und inneren Feinden des Römischen Reiches darlegten. Während Constantius II. im Kampf gegen Alemannen für Frieden plädierte, da seine Gegner von sich aus erkannt hätten, dass ein Sieg gegen die römische Übermacht unmöglich sei, schwor Julian seine Soldaten nach seiner Kaisererhebung gegen Constantius II. zu einem Kriegszug gegen diesen ein. Ein vergleichendes Studium beider Reden erlaubt Einblicke in zeitgenössische Vorstellungen zur Herrschaft der genannten Kaiser. Darüber hinaus verdeutlichen sie Vorstellungen zu Gehalt und Funktion von Krieg und Frieden mit Blick auf imperiale Strategien zur Bewältigung militärischer und politischer Herausforderungen in der Spätantike. Schliesslich ermöglicht eine vertiefte Betrachtung der Quellenzeugnisse Aussagen über die Funktion und Bedeutung kaiserlicher Ansprachen vor dem Heer, sogenannten adlocutiones, auch mit Blick auf ihre literarische Überformung bei Ammianus Marcellinus zu treffen.
La Commission européenne du Danube entre 1856 et 1914, ou l’histoire administrative de la première commission européenne
Authors: Pécaud Dominique , Pipaud Patrice
Published: November 2024

The European Danube Commission is distinguished by the presence of a substantial administrative body associated with a decision-making body made up of diplomats. Administrative action is one of the tasks assigned to it, such as the monitoring of regulations which requires the establishment of a transnational public administration. The originality of the administrative model of the European Danube Commission lies in the need to invent a bureaucratic functioning respecting the primacy of the diplomatic function. This article puts forward the idea that the solutions chosen by this commission contributed to the birth of an administrative practice of international organizations.
Sinema Kethoprak: Perkembangan Kesenian Kethoprak dengan Pendekatan Gaya Film
Authors: Haryono Antonius Janu
Published: November 2024

Perkembangan media internet memaksa banyak kesenian tradisional untuk melakukan penyesuaian agar terus dapat bertahan di tengah arus hiburan yang semakin banyak dan mudah diakses. Dalam beberapa tahun terakhir, kesenian kethoprak juga telah beradaptasi dengan menggabungkan seni pertunjukan tradisional Jawa dengan film yang disebut sinema kethoprak. Youtube merupakan salah satu platform yang banyak digunakan seniman kethoprak untuk mendistribusikan sinema kethoprak. Banyaknya ragam bentuk dan gaya sinema kethoprak yang ada pada platform Youtube memunculkan permasalahan baru tentang bagaimana mempertahankan ciri khas kesenian kethoprak dalam kemasan bentuk dan gaya film. Tujuan penelitian ini adalah memetakan ragam gaya film (film style) yang digunakan pada sinema kethoprak. Teknik pengumpulan data yang digunakan adalah dengan metode observasi terhadap karya-karya sinema kethoprak di youtube yang masih terdapat ciri khas kesenian kethoprak serta elemen-elemen mise en scene, sinematografi, editing dan suara. Dengan pemetaan ini diharapkan dapat bermanfaat untuk merancang atau mendesain gaya sinema kethoprak yang tetap mempertahan nilai-nilai seni dan budaya kethoprak.
Analisis Match Cut dalam Membangun Penceritaan dalam Film Everything Everywhere All at Once
Authors: Sanjaya William
Published: November 2024

Film “Everything Everywhere All At Once” (2022) merupakan film tentang seorang Ibu Rumah Tangga, Evelyn, yang dibawa ke semesta lain ketika ia dihadapkan dengan berbagai masalah pekerjaan dan keluarganya. Film “Everything Everywhere All At Once” (2022) merupakan film yang bertemakan keluarga, yang dikemas dengan kompleksitas perpidahan lokasi atau semesta. Film “Everything Everywhere All At Once” (2022) memiliki transisi match cut yang menarik untuk diangkat. Film “Everything Everywhere All At Once” (2022) juga berhasil mendapatkan 7 dari 11 nominasi penghargaan, salah satunya adalah Best Film Editing dari Academy Awards. Oleh karena itu, penelitian ini dilakukan untuk mengetahui penggunaan match cut dalam membangun tahap peneritaan dalam film “Everythung Everywhere All At Once” (2022). Metode yang digunakan adalah metode kualitatif dengan menggunakan teori match cut oleh Gael Chandler dan teori struktur 5 babak oleh John Yorke. Dari analisis yang telah dilakukan, disimpulkan bahwa match cut memiliki peran dalam membangun cerita. Match cut mengarahkan perhatian penonton sehingga penonton mampu memahami tindakan karakter utama yang berpindah – pindah semesta.
Potret Keragaman Hayati dan Kultural Natuna dalam Bingkai Foto Dokumenter
Authors: Fadillah Kurnia Lucky , Adinur Zein Muhammad Rifki , Febriani Nadia
Published: November 2024

Penelitian ini mengkaji bagaimana keragaman hayati dan kultral di Natuna direkam ke dalam karya foto dokumenter dengan menggunakan teknik EDFAT. Natuna sebagai wilayah yang kaya akan keragaman hayati dan budaya, khususnya dalam aspek kuliner, menjadi fokus dalam proses pembuatan makanan tradisional sagu butir. Foto dokumenter dipilih karena mampu menggabungkan elemen visual dan naratif secara efektif. Penerapan EDFAT menghasilkan foto yang kaya makna. Entire menangkap keseluruhan lokasi dan aktivitas pembuatan sagu butir yang sarat akan konteks kebudayaan lokal. Detail dan Frame menonjolkan aspek yang lebih spesifik dari proses sagu butir dengan komposisi yang menarik. Angle menghadirkan sudut pandang yang memberikan perspektif baru. Time menangkap momen berharga yang tidak dapat diulang seperti ekspresi masyarakat dan tahapan pembuatan sagu butir. Hasil penelitian menunjukkan bahwa teknik EDFAT efektif dalam merekam kekayaan hayati dan budaya Natuna. Foto yang dihasilkan mampu menggambarkan keragaman hayati dan kultural dengan cara yang mendalam dan menyeluruh, menjadikan alat visual yang kuat dalam memahami dan mengomunikasikan potensi daerah Natuna.
Babcock L, Peyser B, Vesterlund L, Weingart L. The No Club, Putting a Stop to Women’s Dead-End Work. Simon and Schuster; 2022. ISBN-13: 978-1982152338.
Authors: Halver Alisha , Monson Elizabeth , Armbrust Sydney , Hursman Allison , Frenzel Jeanne , Richter Lisa
Published: November 2024

This book review of The No Club, Putting a Stop to Women’s Dead-End Work, would serve anyone struggling with burnout or lack of promotion. Supervisors can gain a better understanding of how to distribute non-promotable tasks (NPTs) as well as how to properly and fairly ask their employees to complete NPTs. The hope is that by promoting better understanding of NPTs, both individuals and organizations would see a benefit by preventing burnout, achieving higher promotability, and equitable allocation of workload.
Factors that Influence Healthcare Professionals' Intentions towards Biosimilars
Authors: Alqahtani Mohammed , Al-Jedai Ahmed , Wertheimer Albert
Published: November 2024

Background: Physicians often prescribe original biologic products to patients who have not used them before and are reluctant to switch to biosimilars. Biosimilars are highly similar versions of already-approved biologics, but healthcare professionals typically hesitate to transition patients from the original products to biosimilars. This study aims to investigate the factors that influence U.S. healthcare professionals' intentions to use biosimilars.
Methods: A cross-sectional study was conducted. 510 participants were eligible healthcare professionals (279 physicians and 231 pharmacists). The theory of planned behavior (TPB) is used to identify which factors affect healthcare professionals' intentions.  Descriptive statistics, chi-square, and the logistic regression model tested the TPB constructs as predictors of intentions toward biosimilars.
Results: Among 279 physicians, most were aged 61 and above, with high (n = 142) and low (n = 137) intentions. Male physicians constituted 71% of the population. Attending physicians (66.3%) showed consistent perceptions towards biosimilars, primarily in the private sector (76.3%). Pharmacists (n = 231), a higher percentage of females demonstrated higher intentions compared to males (35.5% vs. 28.1%); the majority were community pharmacists. Associations between years of practice and intentions were significant. Positive correlations existed between beliefs and intentions, except for normative beliefs.
Conclusions: This study revealed diverse attitudes among healthcare professionals towards biosimilars in the USA. Pharmacists and physicians, especially those with limited experience, require ongoing education on biosimilar manufacturing pathways. This education supports the appropriate use of biosimilars and helps standardize federal and state legislation.
Clinical and Financial Outcomes of a Pilot Pharmacist-Led Continuous Glucose Monitoring Clinic
Authors: Ballard Leigh , York Adriane , Skelley Jessica , Sims Marion
Published: November 2024

Abstract
Purpose: What are the clinical and financial benefits of patients using a continuous glucose monitor (CGM) as part of a pilot pharmacist-led service in a Federally Qualified Health Center (FQHC)?
Methods: This single-center, prospective cohort conducted in a FQHC from October 2022 to September 2023 was submitted to IRB for review [EXMT-P-22-F-17]. Patients were seen by a pharmacist in collaboration with an attending physician during diabetes specific visits. Follow-up visits were scheduled in-person every 3 months to obtain a hemoglobin A1c (HbA1c). Reimbursement rates were analyzed to determine financial outcomes of the pharmacy service.
Results: Pharmacists saw 15 patients for their initial CGM visits, with 8 patients returning for follow-up. The average HbA1c at the first visit was 10% + 2.49 and improved at the last follow-up to 8.05% + 0.29. Time in range (TIR) was obtained for 8 patients through the CGM device or online data monitoring. The average TIR 2 weeks after the first pharmacist visit was 39.625% + 23.19 and increased to 48.75% + 11.41 at the completion of the project. A total of 39 visits were conducted, with a total reimbursement rate of $5,978.54.
Conclusion: This pharmacist-led pilot CGM clinic showed improvements in clinical outcomes and provided financial reimbursement for diabetes management in addition to typical office visit revenue. Further research should focus on clinical impact of pharmacist-led continuous glucose monitor clinics in larger patient populations, as well as financial sustainability of the service in both physician clinics and FQHC’s.
Bracketology in Pharmacy Education: The Impact of March Medication Madness on Student Engagement and Knowledge
Authors: Hursman Allison , Petry Natasha , Brynjulson Rebecca , Frenzel Jeanne , Miller Donald , Monson Elizabeth , Orr Megan , Richter Lisa , Viets Nice Joan
Published: November 2024

Introduction. Gamification is being used in pharmacy education as a learning strategy to engage learners with educational content in innovative ways.  Bracketology is one type of gamification that has not been described in pharmacy education literature.  The goal of implementing a March Medication Madness activity was to increase student engagement and knowledge.  The associated study aimed to assess activity goal achievement.
Innovation.  The March Medication Madness project was developed for use in a capstone course offered in the final semester of the didactic pharmacy curriculum.  Students created medication related pearls which were paired together in a 32-team tournament style bracket.  Students then completed brackets to predict the winning pearls and voted biweekly to determine the most clinically significant pearl.  Student knowledge was assessed pre- and post-activity along with a post-activity perception assessment.
Critical Analysis.   Most students either agreed or strongly agreed that the activity increased understanding and stimulated interest in course material, while adding an element of fun to the course. There was a statistically significant increase (t51=3.34, p=0.002) in the average percentage of multiple-choice questions students answered correctly from the pre-test (57.7%±1.5%) to the post-test (63.1%±1.9%).  Pearls that progressed the farthest within the voting were no more likely to be associated with an increase in knowledge than pearls that were eliminated in the first two rounds.
Next Steps.  Implementation of a bracketology activity was perceived as fun and engaging for students, and they felt that it aided in their understanding of course material.  However, the actual increase in knowledge was limited. This shows the importance of structuring gamification in a way that truly provides educational value and enforces the need to make modifications to the activity for future iterations to promote student learning.
Exposing Pharmacy Residents to Implementation Science
Authors: Pinto Anthony Ryan , Nkemdirim Okere Arinze
Published: November 2024

The American Society of Health-System Pharmacists (ASHP) aims to improve patient care by innovating pharmacy practices. ASHP-accredited pharmacy residencies require projects that enhance pharmacy practice, focusing on effective project management and quality improvement. However, only a few of these innovations smoothly become part of routine clinical practice. One solution worth exploring involves teaching Implementation Science in residencies. Exposing residents and mentors to Implementation Science offers two main benefits. Firstly, it helps learn from failed interventions by considering alternative thoughts and grasping environmental influences, leading to smarter decisions in future implementations. Secondly, applying implementation science improves patient care by turning evidence-based practices into practical actions, ensuring better care, consistency across healthcare setups, fewer errors, and tailoring innovative services to specific institutional needs. Exposing pharmacy residents to implementation science pushes forward pharmacy practice by actively applying evidence-based innovations in broader pharmacy or clinical practice.
Community-Based Pharmacists’ Perspectives on Prescribing Authority for the Minor Ailments and Contraceptive Service in British Columbia
Authors: Dahri Karen , Wong Yiu-Ching Jennifer , Loewen Peter , Basi Jiven , Sidhu Sohail , Ragsdale Parkash , Barry Arden , Pammett Rob
Published: November 2024

Background 
Recent changes to legislation in British Columbia (BC) have expanded the scope of pharmacist-provided services to include pharmacist prescribing for minor ailments and contraception (PPMAC). The purpose of this study was to gather community-based pharmacists’ perspectives on these changes to practice.
Methods
This was a cross-sectional online survey study. The study population was pharmacists practicing in community settings in BC. A 28-question survey was developed to capture the uptake of prescribing in the pharmacists’ practices, their views on PPMAC, educational supports, and workplace-specific questions. Invitations to participate were disseminated by using fax, social media platform posts, and email.
Results
A total of 246 participants completed all or part of the survey. A majority felt they should be able to assess and prescribe for minor ailments and contraception, and were satisfied with the regulatory changes. Pharmacists had varying degrees of comfort with prescribing for specific patient populations, with the highest for patients >75 years of age and lowest for patients with renal disease. Respondents felt that patients who were without a primary care provider or did not have easy access to walk-in clinics would benefit the most from PPMAC. Pharmacists expressed concerns about their workplace’s level of support for their providing these new services to patients.
Discussion
Most pharmacist respondents were supportive of and have begun prescribing for minor ailments and contraception in their practices. While they identified many perceived benefits to patient care, workplace barriers may hinder full provision of pharmacist prescribing in their practice.
Prevalence and Predictors of Non-Benzodiazepine Use in Patients with Alcohol Withdrawal Syndrome in United States Emergency Departments – a cross-sectional study
Authors: Zakhary Kirolos , Bruno Sophia , Myatt Caleb , Perera Vindya , Saleh Kerolese , Smearman Jacob , Yuzwa Madeline , Soric Mate , Zampino Stephanie
Published: November 2024

Purpose:
Benzodiazepines are the mainstay treatment in Alcohol Withdrawal Syndrome (AWS), though they have the potential for abuse and cognitive side effects. Non-benzodiazepines are of growing interest for treatment of AWS; however, the prevalence of non-benzodiazepine use remains unknown. The purpose of this study is to evaluate the prevalence and predictors of non-benzodiazepine use for AWS in the Emergency Department (ED).
Methods:
A cross-sectional, retrospective study utilizing data from the National Hospital Ambulatory Medical Care Survey (NHAMCS) spanning the years 2014-2020 investigated patients presenting to the ED with AWS. The primary outcome of this study is the prevalence of patients with AWS who received non-benzodiazepine treatment during their ED visit. The secondary outcome was the identification of predictor variables for non-benzodiazepine use. A multivariate logistic regression with a backward elimination approach was employed to identify predictor variables.
Results:
A total of 2,300 unweighted ED visits included over the study years. When weighted, this represented over 15.2 million ED visits. Across the study period, 3.1% (95% CI, 1.6-6.1%) of patients received non-benzodiazepines. Positive predictors of non-benzodiazepine use included the year 2020 compared to 2014 (OR 6.32, 95% CI, 1.39-28.73) and comorbid depression (OR 4.13, 95% CI, 1.38-12.36). Negative predictors of non-benzodiazepine use included ages 18-40 compared to ages 41-64 (OR 0.34, 95% CI, 0.13-0.91), nursing home residence compared to private residence (OR 0.02, 95% CI, 0.001-0.80), and the South compared to the Midwest region of the United States (OR 0.19, 95% CI, 0.07- 0.51).
Conclusion:
This study found that non-benzodiazepine use, despite being less common, is becoming more prevalent. Further research is needed to determine the optimal dosing and duration of non-benzodiazepines for AWS. Understanding the factors influencing the prescription patterns of non-benzodiazepines can contribute to informed decision-making and improve the management of AWS.
Pengembangan Kreativitas Anggota Pemberdayaan dan Kesejahteraan Keluarga (PKK) melalui Pelatihan Homemade Hampers untuk Meningkatkan UMKM
Authors: Retnoningsih Diyah Ayu , Purwaningsih Dian
Published: November 2024

Tujuan dari diadakannya pengabdian kepada masyarakat ini untuk membangun kemitraan yang kuat dengan ibu-ibu PKK dalam upaya meningkatkan ekonomi produktif di desa Ragatunjung. Kemitraan ini diarahkan untuk mendukung pertumbuhan usaha mikro, kecil, dan menengah (UMKM) serta menggerakkan potensi melalui pembuatan hampers dalam pembangunan ekonomi lokal yang berkelanjutan. Prosedur pengabdian kepada masyarakat ini adalah tahapan persiapan, tahapan pelaksanaan dan tahapan evaluasi. Kegiatan pengabdian ini dilaksanakan bagi anggota PKK Desa Ragatunjung Kecamatan Paguyangan, Brebes. Kegiatan ini yang dilaksanakan terdiri atas ceramah, demonstrasi dan Pratik. Hasil kegiatan berdasarkan respon positif yang diukur melalui observasi bahwa kegiatan memberikan kesan baik dimana berdasarkan presentase antusias peserta memenuhi 80% kehadiran, sedangkan berdasarkan peningkatan Ketrampilan peserta pelatihan akan diobservasi saat pelatihan 70% dari peserta pelatihan mampu menerapkan pemahaman teknik dasar dalam membuat hampers dengan mediadan bahan yang disesdiakan, hal membuktikan kegiatan pengabdian bermanfaat dan tepat sasaran.
Peningkatan Pengetahuan Kader Asuhan Mandiri tentang Pemanfaatan dan Efek Samping dari Tanaman Obat Keluarga (TOGA)
Authors: Sari Putri Eka , Yulianti Tanti , Maharani Ananda
Published: November 2024

Plants have been used to treat various human diseases for thousands of years. Medicinal plants are the main ingredients in tradisional herbal remedies and medicines. With the increasing awarness of healthy lifestyles, family medicinal plants (TOGA) have become an alternative treatment option in the community. The TOGA Self-Care Cadres are at the forefront of efforts to improve public health, especiallu utilization of TOGA. To effectively use TOGA, knowledge is required. This community service activity aims to enhance the knowledge of TOGA Self-Care Cadres regarding the use of TOGA and its potential side effects. The activity was conducted by providing counseling and using pre-test and post-test questionnaires as assesssment intrument for knowledge. The results of the pre-test and post-test were analizyed for normality using the Kolmogorov-Smirnov test, followed by data analysis using the Wilcoxon test. The results showed that in the post-test, 81,25% (13 cadres) had Good knowledge, 18,75% (3 cadre) had Sufficient knowledge, and there were no cadres with Poor knowledge. Statistical tests indicated that the data were not normally distibuted., so the Wilcoxon test was used. Based on the statistical analysis, it can be concluded that the counseling conducted successfully improves the knowledge of TOGA Self-Care Cadres regarding the utilizzation of TOGA and its potential side effects.
Sosialisasi dan Pelatihan Peningkatan Pengetahuan dan Ketrampilan Produksi Home Industri Kerupuk Beras Merah di Desa Jatiluwih Tabanan, Bali
Authors: Sukanteri Ni Putu , Pratiwi Ni Putu Eka , Carina Tiara
Published: November 2024

Jatiluwih Village is one of the villages in Penebel District, Tabanan Regency, Bali Province. The main agrotourism capital of Jatiluwih Village is the agribusiness activity of red rice production, terraced rice fields and natural beauty. In creating various products that empower the community in Jatiluwih Village. The home industry aims to promote local products produced by the community in Jtiluwih Village. The aim of implementing the activity is to empower groups to become economically active groups through home industry productivity. Increase the knowledge and skills of group members in the field of production and marketing of the home industry of red sandalwood rice crackers. Developing the Jatiluwih Village PKK group to be economically independent. The activity method is carried out through socialization, training and mentoring in the PKK Group in Jatiluwih Village, Penebel District, Tabanan Regency, Bali Province. Community service activities carried out by PKK members in Jatiluwih Village, in an effort to develop the home industry, are as follows: Socialization of product hygiene shows that the knowledge of PKK members in Jatiluwih Village has increased by up to 100%. Training given to Jatiluwih Village PKK members in the use of grinding machines and mixers showed an increase of up to 80%. This shows that home industrial activities in Jatiluwih Village make it possible to increase production volume with training and mentoring.
Novel long pulse potassium-titanyl-phosphate with substructured pulses – An effective tool in treating post-inflammatory erythema: A report of two cases in darker skin
Authors: Almutairi Rawan , Usmani Saima , Mubarak Sarah , Al-Daraji Wael
Published: November 2024

The utilization of lasers is advancing as the range of applications for laser therapy expands, and new devices have been introduced. Vascular coagulation, pigment ablation, skin regeneration, tissue cutting or ablation, and hair removal are the five primary applications of laser therapy for the treatment of dermatological conditions. We present two cases of female patients with bilateral facial redness, one due to electromedical plasmage and the other from fractional carbon dioxide (CO2) laser, in which the target of their therapy was to improve acne scarring. Facial redness in both cases was successfully treated using a potassium-titanyl-phosphate (KTP) laser with cryogen cooling. The KTP laser has demonstrated efficacy in treating erythema associated with various conditions, including CO2 fractional laser and plasmage therapy. One of the advantages of the KTP laser is that it minimizes post-operative purpura and erythema, making it a favorable option for treating erythema itself.
Quantifying Marine Oil Slick using the Hydrocarbon Spectra Slope Index (HYSS): A Case Study of the 2010 Deep-water Horizon Spill in the Gulf of Mexico
Authors: Olagunju Kamorudeen Tunde , Callen Scott Allen , Olobaniyi Samuel Bamidele , Oyedele Kayode Festus
Published: November 2024

Mapping the extent and quantifying oil slick in ocean spills is one of the major objectives for monitoring and clean-up programs. Hyperspectral sensors are among the few remote sensing tools with potential for quantifying hydrocarbon oil on water and on other background substrates. At present, methods used to process hyperspectral data for quantifying hydrocarbon oil relies on delineating shapes and wavelength position of key diagnostic features within shortwave infrared (SWIR), particularly at 1.73µm and 2.30µm, which are often affected by the spectral features from the background substrates. Rather than the shape, the absorption maxima of hydrocarbon diagnostic features has shown potential for quantifying oil slick abundance classes via the Hydrocarbon Spectral Slope index (HYSS). In this research, the discriminative power of HYSS index for quantifying ocean oil slick is demonstrated, using Advance Visible and Infrared Imaging Spectrometer (AVIRIS) data from the 2010 Deep-water Horizon (DHW) spill from the Macondo well-head in the Gulf of Mexico. The results suggest good discrimination of oil and water as well as quantification of the oil slick into different oil abundance classes, representing different oil-water ratio and/or thickness. The validation of HYSS results shows good agreement with visual records of the spill within the image scene. Five oil abundance classes were discernible from studied AVIRIS scenes. These results were obtained empirically, without site-specific reference spectra, suggestive of a potential index for rapid broad area search. Change detection statistics of oil coverage at three separate intersects (ITT 1, ITT 2, and ITT 3) with before and after image coverage show reduced oil coverage percentages of 70%, 11.5%, and 0% respectively. These percentage reductions are in agreement with visual display of oil coverage as affected by dispersion induced by ocean currents and chemical dispersant application within the respective time lags of these image data acquisition.