bluuebunny/crossref_metadata_2025 huggingface dataset:
La main du traducteur
Authors: Arnould Jean-Claude
Published: July 2024

L’étude des oeuvres traduites par Belleforest durant un quart de siècle révèle, sans surprise, l’absence chez lui d’une réflexion sur la question cruciale de la « fidélité ». Il est en revanche très disert sur les motifs de cette pratique et ses objectifs. C’est que sa conception du rôle de traducteur va bien au-delà d’un passeur de textes et d’idées. Ses discours d’escorte en particulier révèlent qu’il envisage le traducteur comme un collaborateur de l’auteur étranger ou même un auteur en second, dont l’autorité s’affirme de multiples manières au point qu’il s’imagine comme un auteur de plein exercice.
La colère dans les Histoires tragiques de François de Belleforest : une lecture augustinienne
Authors: Méniel Bruno
Published: July 2024

Si l’histoire tragique offre la représentation d’un univers historique animé par des passions violentes, elle construit aussi l’image d’une société où la colère change de nature et de fonction selon les catégories sociales. La tension existant entre l’aptitude de la colère à se mettre au service des grandes valeurs éthiques de la Renaissance et son incapacité à répondre aux exigences de l’humanité, de la raison, de la justice et de la mesure rend la colère tragique. La colère n’est ni bonne, ni mauvaise en soi mais elle est un des effets de la misère humaine, qui elle-même est la conséquence du péché originel. Dans l’univers créé par Belleforest comme dans celui décrit par Augustin, la cité des hommes et la cité de Dieu sont indistinctement mêlées. La colère de qui vit selon la chair est mauvaise, celle de qui vit selon l’esprit est bonne. L’éthique des Histoires tragiques pourrait bien témoigner de la forte empreinte laissée sur Belleforest par la méditation de la Cité de Dieu de saint Augustin.
Emprunts et empreintes : la reine Gertrude de Belleforest et celle de Shakespeare
Authors: Ganim Russell
Published: July 2024

Il s’agit de tracer l’influence de François de Belleforest sur William Shakespeare à travers le personnage de Gertrude (nommé « Geruthe » chez Belleforest) dans la pièce Hamlet. S’appuyant sur la légende danoise originale de Saxo Grammaticus (Historia Danica), c’est Belleforest dans les Histoires tragiques qui donne une voix à celle qui est à la fois mère du protagoniste (se nommant « Amleth » chez Belleforest) et reine du Danemark. Par la suite, Shakespeare élabore et approfondit le portrait de Gertrude. S’inspirant largement de l’exemple de Belleforest, le dramaturge élisabéthain met en valeur la rupture psychologique entre Hamlet et sa mère, soulignant surtout l’évolution de leur rapport qui passe du conflit à la réconciliation au cours de la tragédie. La représentation belleforestienne de Geruthe comprend aussi son rôle ambigu dans les nombreux complots du roi contre Amleth. Ces manigances sont adaptées par Shakespeare pour augmenter la tension du drame et pour faire de Gertrude elle-même un personnage tragique.
Las Monedas Digitales de los Bancos Centrales (CBDC) y la Ciencia de Datos como herramientas contra la delincuencia
Authors: Jaimes Becerra Jesus Ramon , Perez Rivas Natali Yormeri , Oña Dominguez Ángel Andrés , Campaña Chaglla Jimena Alexandra , Salazar López Jairo Javier , Intriago Alcivar Josselin Magdalena
Published: July 2024

El presente artículo tiene como objetivo mostrar cómo la Moneda Digital de los Bancos Centrales (CBDC), en conjunto con el análisis de datos y otras herramientas tecnológicas, pueden ser utilizadas para construir modelos capaces de predecir el comportamiento delictivo de los usuarios y combatir delitos como el lavado de dinero, el narcotráfico y la corrupción en América Latina. Para lo cual se utiliza una investigación documental apoyado en un nivel de estudio descriptivo con un diseño bibliográfico, con el fin de mostrar la implementación de estos instrumentos en América Latina, realizando una revisión exhaustiva de la literatura académica, explicando el sistema blockchain, y el uso que han tenido las CBDC en algunos países de Suramérica; mostrando cómo su naturaleza digital deja un rastro que puede ser monitoreado y analizado por las autoridades, permitiendo predecir situaciones. Finalmente, se concluye que la adopción de las CBDC, en conjunto con el uso de la Ciencia de Datos y herramientas de la inteligencia artificial, pueden ser útiles para la prevención del delito.
Emprendimiento de mujeres en Guayas y Los Ríos -Ecuador: innovación, financiamiento y sostenibilidad
Authors: Barzola Jimenez Mery Katty
Published: July 2024

El presente estudio tiene como objetivo diagnosticar el limitado acceso a financiamiento, baja preparación en Science, Technology, Engineering and Mathematic (STEM) y corta sostenibilidad dentro de los negocios que  experimentan las emprendedoras. Se utilizó una muestra homogénea combinada con la muestra de casos  tipo, o llamadas “muestras típicas o intensivas” de 134 mujeres emprendedoras de las provincias de Guayas y Los Ríos. Se adaptó el diseño secuencial; es decir, los datos recolectados y analizados en una fase del estudio (CUAL) con información secundaria se presentaron las supuestas causas que originan las variables descritas, se realizó la encuesta utilizando un formulario de Google. Luego estos datos se utilizaron para informar a la otra fase (CUAN), donde se relacionaron las categorías precio y expectativas del negocio, también un análisis inferencial para determinar las diferencias entre las categorías indicadas y se aplicaron pruebas de Kruskal-Wallis. Los resultados indican que el 50,7 % de las emprendedoras no tiene Registro Único de Contribuyentes (RUC) o Régimen Impositivo para Microempresas (RIMPE), lo que es el reflejo de una informalidad; un 53 % de las emprendedoras se financió a través de sus familias, un 4,7 % por ahorros y sólo un 40 % ha lanzado un nuevo producto o servicio en los últimos tres años. Se concluye que todos los esfuerzos en impulsar el emprendimiento femenino deben tener su accionar concreto en una participación más intensa de la mujer en la transformación digital empresarial y adicionar otros servicios financieros a los ya existentes en Ley de Emprendimiento del Ecuador.
Influencia de la personalidad e imagen de destino en la elección de un destino turístico (intención de compra)
Authors: Calle Marcelo , Pineda Jorge
Published: July 2024

El sector turístico ha sido uno de los más afectados por la pandemia de coronavirus COVID-19 generando disminución de la movilidad  hacia destinos turísticos, pérdidas económicas e incertidumbre laboral. A raíz de estos sucesos se justifica la importancia a contribuir con investigaciones que ayuden a la reactivación económica de este sector, siendo que comprender el comportamiento del consumidor (turistas) podría suponer un desafío para los especialistas en marketing y para los gerentes de los destinos turísticos. Este estudio intenta determinar si la personalidad y la imagen de destino influyen en los jóvenes al momento de elegir su destino turístico y brindar la información de la que carecen los directivos de organizaciones turísticas debido a las escasas investigaciones de estas variables. Por medio de la revisión literaria se identificaron que la imagen y la personalidad del destino podrían influir en la decisión del turista de elegir un destino turístico. La metodología se llevó a cabo bajo una investigación descriptiva, con un enfoque cuantitativo, mediante la aplicación de encuestas usando cuestionarios validados. Los resultados obtenidos determinan la influencia positiva de las variables antes mencionadas en la elección un destino turístico. Las conclusiones pueden ayudar a los administradores de los distintos destinos turísticos a desarrollar estrategias conforme a lo que posiblemente los consumidores más valoran al momento de decidir su próximo destino a visitar y esto puede estimular la economía de un determinado lugar.
Eficiencia técnica del cultivo de cacao (Theobroma cacao L) en el sur de Córdoba, Colombia
Authors: Martínez Reina Antonio María , Tordecilla Zumaqué Lilibeth , Grandett Martinez Liliana María , Rodriguez Pinto María del Valle , Díaz Cabadiaz Abelardo , Ballesteros Leal Henry Andrés
Published: July 2024

La región del sur del departamento de Córdoba, Colombia, en los últimos diez años ha presentado un crecimiento en el cultivo del cacao (Theobroma cacao L.) como alternativa de sustitución de cultivos ilícitos y de mejoras en la calidad de vida de las familias que han atravesado el conflicto  armado. El sistema de producción ha mostrado  potencialidad dado sus rendimientos que superan al promedio nacional; sin embargo, no se evidencia la presencia de un estudio que indague acerca de la eficiencia en la asignación o inversión de recursos. Este trabajo tuvo como objetivo determinar la eficiencia técnica de este cultivo con información obtenida de una encuesta estructurada y aplicada a 158 cacaoteros de los municipios de Puerto Libertador, Montelíbano, Tierralta y Valencia. La información obtenida contenía variables técnicas y socioeconómicas que permitieron calcular el estado actual de la eficiencia técnica del cultivo del cacao para esta región, del país. La técnica que se usó fue la de frontera estocástica a través de la estimación de parámetros por el método de mínimos cuadrados a una función de producción tipo Cobb Douglas. A pesar de que los rendimientos no son bajos, los resultados muestran que el agricultor presenta una eficiencia técnica del 39%, lo cual se atribuye a la subutilización de factores y ocasiona una brecha en la producción. Se concluye que esta ineficiencia también está asociada a factores sociales como edad avanzada de los agricultores y los bajos niveles de escolaridad principalmente.
Estudio etnobotánico de plantas medicinales del Humedal Abras de Mantequilla y su área de influencia cantón Vinces.
Authors: Jiménez Romero Edwin Miguel , Crespo Gutierrez Rommel Santiago , Moreno Vera Ana Noemi , Sánchez Fonseca Carlos Luis , Eguez Enriquez Erick Alberto
Published: July 2024

Se determinó el uso etnobotánico de plantas medicinales en el humedal Abras de Mantequilla y su área de influencia, se aplicaron un total de 46 encuestas analíticas. Se registraron 39 especies, 36 géneros y 28 familias de plantas de uso medicinal, las especies con mayor frecuencia fueron Cymbopogon citratus, Origanum vulgare y Valeriana officinalis, las enfermedades de la categoría gastrointestinal obtuvieron el mayor porcentaje de cura de las especies vegetales, el mayor porcentaje de tratamiento fueron  la preparación  por cocción. C. citratus, O. vulgare y V. officinalis registraron mayor Índice de Valor de Uso (IVU), Conocimiento Relativo de las Especies (RVU) y Uso Significativo de Trámil (UST).
Técnicas más utilizadas para conservación de productos pesqueros de la amazonia ecuatoriana
Authors: Aguiar Novillo Santiago Nicolás , Enríquez Estrella Miguel Ángel , Chicaiza Reisancho Edgar Rubén , Uvidia Cabadiana Hernán Alberto
Published: July 2024

Los productos pesqueros amazónicos constituyen un componente indispensable en la seguridad alimentaria de los pueblos amazónicos del Ecuador. Este trabajo de revisión analiza las principales técnicas de conservación que garantizan la calidad e inocuidad de los productos pesqueros amazónicos que tienen una vida útil relativamente corta, se empleó una metodología descriptiva basada en el método PRISMA que incluyen varias investigaciones demostrado el uso de diferentes tecnologías de conservación (congelación, salazón, ahumado, envasado al vacío) aplicadas en la región capaces de extender la vida útil post mortem de los mismos. Los procesos de congelación tienen una mayor capacidad para alargar la vida útil de los productos pesqueros en comparación con la refrigeración convencional, sin embargo, en esta región que se practica la pesca artesanal no garantizan una cadena de frío eficaz. El envasado al vacío tiene un gran potencial para el envasado de productos pesqueros frescos. El uso de tecnologías no térmicas, como el ahumado tradicional además de la salazón propios de los pueblos nativos, se presentan como alternativas para la conservación de los productos pesqueros locales.
ENTOMOPATHOGENIC NEMATODES ASSOCIATION WITH SOIL- DWELLING BACTERIA: THE CASE OF STEINERNEMA FELTIAE
Authors: RUIU LUCA , LI XINGYUE , TARASCO EUSTACHIO
Published: July 2024

The symbiosis of entomopathogenic nematodes (EPNs) with bacteria in the genera Photorhabdus and Xenorhabdus is well known. However, other soil-dwelling bacteria can occasionally be isolated from EPNs collected from diseased larvae. Accordingly, through several studies, we have detected the presence of diverse bacterial species including isolates of Pseudomonas protegens and Serratia spp., in the body of different strains of the entomopathogenic nematode Steinernema feltiae. After documenting the presence of such bacteria inside the nematodes, both nematodes and EPN-associated bacteria were cultured, and bioassays were conducted to determine their potential against different insect targets. An isolate of P. protegens caused over 60% and 90% mortality of house fly and corn earworm larvae, respectively. These insecticidal effects were dose-dependent. The presence of the bacterium confers virulence to the nematode. According to our studies, it appears that these non-core bacteria can establish occasional or stable associations with S. feltiae. Key Words: Biological control, EPN, bacteria, symbiosis, Pseudomonas, soil, bioinsecticide.
Extended cycles of adjuvant temozolomide improves survival outcomes in glioblastoma: a retrospective analysis
Authors: Xu Hao , Yu Shengnan , Wang Chunyan , Hu Yue , Ren Qinglan , Jiang Lihao
Published: July 2024

Aim: Standard treatment includes post-surgical chemoradiotherapy and adjuvant temozolomide (TMZ) for glioblastoma (GBM). There is no consensus on the optimal duration for adjuvant TMZ. This study assessed whether prolonging adjuvant TMZ improved survival outcomes.

Methods: We retrospectively analyzed data of GBM patients who met inclusion criteria at our institute from September 2013 to December 2022. Patients who received 6 cycles of maintenance TMZ constituted the standard group, whereas those who underwent > 6 cycles were classified into the extended group. Kaplan-Meier method was used to estimate the median progression-free survival (PFS) and overall survival (OS). Independent predictors of OS and PFS were explored by Cox regression analyses.

Results: 100 patients were enrolled. Extended adjuvant TMZ significantly improved OS (28.0 vs. 10.0 months, P < 0.001) and PFS (22.0 vs. 8.0 months, P < 0.001) in newly diagnosed GBM patients. Subgroup analysis showed that patients with MGMT promoter methylation who received > 6 cycles of adjuvant TMZ experienced a significant increase in OS (34.0 vs. 9.0 months, P < 0.001) and PFS (26.0 vs. 9.0 months, P = 0.008). Additionally, in the extended group, patients with MGMT promoter methylation had better survival outcomes compared to MGMT promoter unmethylated patients (OS: 34.0 vs. 17.0 months, P = 0.013; PFS: 26.0 vs. 12.0 months, P = 0.025). In patients with solitary GBM, extended adjuvant TMZ resulted in better OS (11.0 vs. 32 months, P = 0.007) and PFS (9.0 vs. 24.0 months, P < 0.001). For patients with multiple GBM, undergoing six or more cycles of adjuvant TMZ did not significantly impact OS (P = 0.100) and PFS (P = 0.067). The Karnofsky Performance Status (KPS) is employed to assess the health condition of surgical patients. Patients with KPS > 70 exhibited better survival outcomes in the extended group. Nausea and vomiting were the main adverse events reported in both cohorts. However, fatigue emerged as the most severe side effect, specifically within the extended group.

Conclusion: This study indicated that prolonged adjuvant TMZ significantly enhanced OS and PFS in GBM, and the adverse events were acceptable. The benefits were particularly notable in those with MGMT promoter methylation, solitary GBM, and high KPS. The optimal cycles of adjuvant TMZ require large prospective studies to further validate and identify which patient groups benefit the most based on molecular subtyping and clinical characteristics.
Glioma-associated oncogene (GLI)-specific decoy oligodeoxynucleotide induces apoptosis and attenuates proliferation, colony formation, and migration in liver cancer cells
Authors: Hajilou Zahra , Solhi Roya , Shokouhian Bahare , Torabi Shukoofeh , Heydari Zahra , Farzaneh Zahra , Bahadori Sadaf , Piryaei Abbas , Hassan Moustapha , Nussler Andreas K. , Vosough Massoud
Published: July 2024

Aim: Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-associated death. The Sonic Hedgehog (SHH) signaling pathway participates in the initiation, progression, migration, and recurrence of HCC cancer stem cells. Furthermore, SHH regulates various cellular behaviors such as proliferation, differentiation, survival, self-renewal, epithelial-mesenchymal transition (EMT), and SHH autoregulation. Glioma-associated oncogene (GLI) family zinc finger are key transcription factors in the development of many organs and are deregulated in cancer. In this study, Huh-7 cells were treated with GLI-specific decoy oligodeoxynucleotide (ODN) to evaluate its anticancer impact.

Methods: The transfection efficiency of GLI-specific decoy ODN was measured using fluorescent microscopy. Then, the effects of GLI-specific decoy ODN on apoptosis, viability, proliferation rate, colony formation, and migration capacities of Huh-7 cells were assessed. Furthermore, the expression of genes associated with the alteration of SHH was assessed.

Results: Treatment of Huh-7 cells with GLI-specific decoy ODN decreased cell viability (56.36% ± 3%). Expression of certain genes such as c-MYC , SNAI2 , ZEB1 , and PROM1 decreased dramatically, while the expression of CDH1 increased significantly. Furthermore, the treated cells’ proliferation, colony formation, and migration capacity decreased considerably. This treatment induced apoptosis in the Huh-7 cells.

Conclusion: Inhibition of the SHH signaling pathway using GLI-specific decoy ODN led to a decline in the growth rate of HCC cells, decreased migration, and attenuated EMT progression.
Aberrant blood-brain barrier dynamics in cerebral small vessel disease - a review of associations, pathomechanisms and therapeutic potentials
Authors: Zul Ramli Sayyidah Maryamul Azra’ , Abdul Hamid Hafizah , Che Mohd Nassir Che Mohd Nasril , A Rahaman Siti Nurulnabila , Mehat Muhammad Zulfadli , Kumar Jaya , Lee Si-Yuen , Mustapha Muzaimi
Published: July 2024

This review explores the pivotal role of the blood-brain barrier (BBB) in maintaining central nervous system (CNS) homeostasis and its dynamic involvement in the pathogenesis of cerebral small vessel disease (CSVD), i.e., the major precursor of age-related neurodegenerative diseases such as vascular dementia and Alzheimer’s disease. It underscores the BBB as a critical physiological boundary that regulates the exchange between the bloodstream and the cerebral milieu through a complex and dynamic interface composed of endothelial cells, astrocyte endfeet, and pericytes. The integrity of this barrier is paramount for neural function, shielding the brain from toxicants and pathogens while facilitating the transport of essential nutrients. Nevertheless, BBB dysfunction is recognized as a lead in the pathogenesis of neurodegeneration including CSVD, emphasizing the need for focused research on maintaining or restoring BBB function. This review highlights recent advancements in our understanding of BBB dynamics in both health and disease states, its involvement in CSVD pathomechanisms, and the challenges and future directions of translational research and emerging technologies. The review advocates for a multidisciplinary approach to uncover the complexity of BBB dysfunction in CSVD, as well as insights into potential therapeutic targets aimed at preserving BBB integrity, thereby minimizing its impact given the notable world’s aging demographics.
Detection and Distribution of Residues and Additives in Meat and Meat Products in Zenica-Doboj Canton, Bosnia and Herzegovina
Authors: Hasanbasic Dzenana , Kovač ćamka , Ibrahimagić Amir
Published: July 2024

Objectives: Many additives are of essential importance for the taste and quality of products, however, many of them pose a danger to human health, and are subject to daily routine quality control of products intended for human consumption. In addition to additives, residues represent a major challenge as possible contaminants of products from the field to the dining table. Methods: Through the research, 85 samples of meat products (salami, sausages, dried meat products) were processed and all were analyzed for the presence of aflatoxin B1 (AFL B1), as well as for chlorides, nitrites and heavy metals (cadmium and lead). Results: The average content of AFL B1 in the meat samples was 0.048 µg/kg (0.019 to 0.105 µg/kg). Chloride content was detected in the range from 0.000 to 9.955 %m/m (average concentration 2.377 %m/m). The average nitrite content was 8.330 mg/kg (min. 0.550 – max. 45.705 mg/kg). Among the 85 processed samples, lead and cadmium were detected in 79 and 29 products (92.94% and 34.11%), with an average of 0.136 and 0.042 mg/kg, respectively. Lead was detected in the range from 0.000 to 3.474 mg/kg, and cadmium from 0.000 to 2.544 mg/kg. Conclusions: The results show the need for continuous monitoring of the amount of additives in meet products on the market, and regular monitoring of residues in products intended for human consumption. It is necessary to stick to proper hygienic practices during the preparation of the product at all stages from the field to the dining table.

Keywords: residues, additives, lead, cadmium, public health
ANÁLISE ESTRATÉGICA DE INVESTIMENTOS NA PECUÁRIA LEITEIRA: INTRODUÇÃO DE NOVOS INDICADORES DE EFICIÊNCIA E RISCO
Authors: Carvalho Bassotto Leandro , Lopes Marcos Aurélio , Ribeiro Lima André Luis , Albuqerque Merlo Fernanda
Published: July 2024

Apesar da importância da pecuária leiteira para o agronegócio nacional, poucas pesquisas analisam questões relacionadas à eficiência e ao risco ligados ao aumento dos investimentos, sob a perspectiva da Teoria da Firma. Assim, questiona-se: Como os investimentos podem impactar a eficiência e os riscos em propriedades leiteiras? Objetivou-se analisar os impactos dos investimentos no desempenho econômico em propriedades leiteiras e, especificamente, (i) propor dois indicadores de eficiência e risco. Realizou-se duas analises estatísticas (teste de comparação de médias e Correlação de Pearson), utilizando-se o software IBM SPSS®. O Ponto de Equilíbrio do Investimento (PEI) permitiu comparar a viabilidade econômica de um investimento no momento em que a rentabilidade com e sem sua realização serão iguais; e a Relação Risco/Investimento (RRI) indicou a representatividade das depreciações sobre o capital de giro, sendo um indicador de risco advindo do aumento (excessivo) do capital investido sobre o desempenho econômico de propriedades leiteiras. As propriedades com RRI inferior a 50% estavam menos expostas a riscos ocasionados pelo excesso de investimentos. Conclui-se que o aumento (excessivo) dos investimentos reduz a eficiência e eleva os riscos da atividade leiteira.
FUNGOS ENDOFÍTICOS PRODUTORES DE L-ASPARAGINASE ASSOCIADOS ÀS PLANTAS MEDICINAIS AMAZÔNICAS Himatanthus sucuuba (Spruce ex Müll. Arg.) Woodson E Calycophyllum spruceanum (Benth.) K. Schum
Authors: Dos Santos Prado Laryssa , Martins de Lima Antonia Jerlene , Rodrigues Pereira Valcirene , Viana Diniz Fernanda , Maia Carvalho Clarice
Published: July 2024

As enzimas de origem microbiana são compostos naturais de grande relevância para a indústria farmacêutica, sendo a L-asparaginase uma dessas enzimas. Por ser importante no tratamento da leucemia linfoblástica aguda (LAA), é primordial encontrar novas fontes de L-asparaginase. Uma fonte em potencial de L-asparaginase são fungos endofíticos de plantas medicinais. Assim, este estudo teve como objetivo selecionar fungos endofíticos produtores de L-asparaginase associados às plantas medicinais amazônicas H. sucuuba e C. spruceanum. Os fungos endofíticos foram reativados em meio BDA e identificados por análise morfológica. Para realização do ensaio enzimático, foram produzidas culturas puras dos microrganismos. Os fungos foram crescidos em meio BDA por 7 dias à 28 ºC. Três plugues de micélio fúngico foram inoculados em ágar modificado Czapex Dox-McDox e incubados a 28 ºC por 7 dias. Após incubação, foi verificada a mudança de coloração do meio de cultura de amarelo para azul. Um total de 38 fungos endofíticos foram reativados, onde 34 isolados (89,47%) foram positivos para a produção da enzima, com destaque para fungos dos gêneros Colletotrichum, Fusarium, Lasiodiploidia, Paecilomyces, Penicillium, Pestalotiopsis, Phomopsis, Trichoderma e Xylaria. As plantas medicinais amazônicas H. sucuuba e C. spruceanum abrigam fungos endofíticos com potencial para a produção de L-asparginase.
DESENVOLVIMENTO DE APLICAÇÃO IMERSIVA EDUCACIONAL: O SISTEMA SOLAR EM REALIDADE VIRTUAL
Authors: dos Santos Gustavo Silvestre , Andrade Vinicius , Poiet Sampedro Paula
Published: July 2024

Com o avanço e, consequentemente, a popularização de determinadas tecnologias, é comum o uso de sistemas computacionais nas mais diversas áreas, tais como: jogos digitais, educação, publicidade e propaganda, construção civil, arquitetura, entre outras. Ademais, o uso da tecnologia junto às metodologias ativas de ensino, possibilita que as atividades sejam mais dinâmicas e se tornem diferenciais no processo de ensino e aprendizagem. No entanto, cabe-se o questionamento de como tornar essa aplicação interessante aos olhos dos alunos, sem se apoiar apenas no chamariz da tecnologia. Esse problema direcionou a pesquisa ao objetivo de desenvolver uma aplicação imersiva, utilizando de Realidade Virtual (RV), para uso no ambiente educacional. A temática escolhida para a aplicação foi “O sistema solar”, e essa se desenvolveu sob duas frente, a primeira teórica, fundamenta os dados exibidos durante a interação, estuda sua viabilidade, as ferramentas computacionais utilizadas e a usabilidade dentro da Experiência do Usuário (UX); a segunda observa o desenvolvimento prático: proposta de modelos 3D e implementação do ambiente virtual. Essa pesquisa demonstra a criação de uma aplicação mobile em Realidade Virtual, discute sua viabilidade em ambientes de ensino formais e/ou não formais sob a luz da Experiência do Usuário.
Solution of the Capacitated Lot-Sizing Problem with Remanufacturing (CLSPR) in a General Way with the Help of Simulation and Relaxation
Authors: Rocha Luis
Published: July 2024

The capacitated lot-sizing problem with product recovery (CLSP-RM) holds significant importance in reverse logistics but is notoriously complex (NP-hard). In this study, two techniques are introduced to confront this challenge. The first technique entails devising a linear optimization task that eliminates capacity limitations across a wide problem spectrum, yielding a remarkably accurate approximation of the optimal solution. This adaptable approach presents a potent alternative and holds potential for extension to diverse problem categories owing to its versatile nature. The second technique employs a simulation methodology utilizing Halton’s uniform random numbers to address the issue. This randomized production search method sidesteps considerations of production costs, inventory expenditures, and production order when determining production batches. The research’s novelty lies in its application of these techniques to the problem. The suggested methods undergo evaluation via a benchmark dataset of approximately 4200 instances, with comparison against solutions derived through the Gurobi solver. The results underscore the efficacy and resilience of the introduced methodology in tackling the CLSP-RM predicament.
Review of Probabilistic Modeling of Pavement Performance Using Markov Chains
Authors: Yamany Mohamed S. , Abraham Dulcy M. , Nantung Tommy E. , Labi Samuel
Published: July 2024

Reliable models of pavement performance play a crucial role in effective decision-making for maintaining and rehabilitating this class of infrastructure assets. Probabilistic modeling approaches have gained popularity in pavement performance modeling because they account not only for the stochastic nature of pavement behavior and deterioration factor variations but also for the imperfections and inadequacy of pavement condition data in certain situations. One of these approaches, Markov chains, has been used extensively to model the probabilistic performance of pavements through an interesting variety of methodological tweaks in the Markov model structure. Unfortunately, the current literature lacks a synthesis of Markov chain models and their associated methodologies, as used in this manner. It is anticipated that a comprehensive synthesis of these models and their various forms can provide some insight into the variations of Markov model forms and methodologies, and the appropriate Markov model type to use for pavement deterioration and performance modeling under given conditions of data types and availability. To address this issue, this paper reviews Markov chain models used in the literature to model pavement deterioration and the methodologies used to estimate the transition probabilities matrix which is the key feature of Markov chain models. The paper presents a critical analysis of various aspects of Markov chain models as they were applied in the literature, reveals gaps in knowledge, and offers suggestions to address these gaps. The paper also develops a decision tree to select the appropriate Markov model type and TPM estimation methodology to model pavement deterioration under given conditions of data availability. This paper therefore provide guidance and decision support for researchers and highway agencies in selecting an appropriate probabilistic technique for modeling their pavement infrastructure performance in a robust manner.
The Effects of Lutein/ Zeaxanthin (Lute-Gen®) on Eye Health, Eye Strain, Sleep Quality, and Attention in High Electronic Screen Users: A Randomized, Double-Blind, Placebo-Controlled Study
Authors: Lopresti Adrian Leone , Smith Stephen James
Published: July 2024

Background: Lutein and zeaxanthin are fat-soluble antioxidant nutrients that have evidence of beneficial effects on vision and eye health. The purpose of this study was to examine the effects of supplementation with lutein and zeaxanthin isomers (Lute-gen®) on eye health, eye strain, sleep quality, and attention in high electronic users. Study design: Two-arm, 6-month, parallel-group, randomized, double-blind, placebo-controlled trial. Methods: Seventy volunteers aged 18 to 65 who used electronic screens for more than 6 hours daily were supplemented with 10 mg of lutein and 2mg of zeaxanthin-isomers or a placebo. Outcome measures included several ophthalmic examinations comprising the Schirmer tear test, photo-stress recovery time, contrast sensitivity, tear film break-up time, and self-report measures of visual fatigue, computer vision, sleep quality and attention. Results: Compared to the placebo, lutein and zeaxanthin supplementation was associated with greater improvements in the Schirmer tear test, photo-stress recovery time, and tear film break-up time. However, there were no group differences in the change in self-report measures or contrast sensitivity. Lutein and zeaxanthin supplementation was well-tolerated, with no reports of serious adverse reactions or clinically significant changes in safety blood measures, including liver function, renal function, blood lipids, and full blood examination. Conclusions: The results from this study provide support for the beneficial effects of 6 months of lutein and zeaxanthin supplementation on visual health and dry eyes in regular users of electronic screens. However, these findings were not corroborated by group differences in the administered self-report questionnaires.
Physical Attributes of Soil and Productivity in Intercropped Sorghum Grain within No-Tillage Cropping System
Authors: Soares Eduarda Santana , Seron Ana Carina da Silva Cândido , Roque Cassiano Garcia , Santana Dthenifer Cordeiro , Gossler Fabrício Ely , Ribeiro Vitor Barbosa , Galina Gustavo Rodrigues , da Silva Tullio Fernandes
Published: July 2024

A favorable physical environment in the soil is necessary and of fundamental importance for the growth and root development of the sorghum crop, in order to maximize the productivity of the planted crops. In this study we evaluated the physical aspects of the soil in no-tillage system in a sorghum grain area intercropped with Urochloa ruziziensis and Crotalaria spectabilis and the productivity of the crop, in off-season (second crop season), based in a long field experiment. The experimental design was a randomized block design in a 4 x 4 factorial arrangement (four cropping systems: sorghum, sorghum + Urochloa ruziziensis, sorghum + Crotalaria spectabilis, sorghum + Urochloa ruziziensis + Crotalaria spectabilis; four soil depths: 0 - 0.10 m, 0.10 - 0.20 m, 0.20 - 0.30 m, 0.30 - 0.40 m). It was analyzed the productivity and the physical soil attributes that were: Soil Bulk Density (DS), Gravimetric Moisture (GM), Total Porosity (TP), Microporosity (MI), Macroporosity (MA) and Resistance to Root Penetration (RP). The study asserts that intercropping sorghum with Crotalaria spectabilis is a promising strategy to increase productivity. The Sorghum + Urochloa ruziziensis + Crotalaria spectabilis combination significantly improves soil structure by reducing penetration resistance and increasing macroporosity, especially at depths greater than 0.20 m. The inclusion of Urochloa enhances moisture retention, while Crotalaria contributes to greater porosity.
Markov Chain Based Statistic Model for Predicting Particle Movement in Circulating Fluidized Bed (CFB) Risers
Authors: Zhuang Yaming , Liu Fangfang
Published: July 2024

To increase the calculation speed of the computational fluid dynamics (CFD) based simulation for the gas-solid flow in fluidized beds, a Markov chain model (MCM) is developed to simulate the particle movement in a two-dimensional (2D) circulating fluidized bed (CFB) riser. As a statistic model, the MCM takes the CFD-discrete element method (DEM) results as samples to calculate the transition probability matrix of particles, which can describe the macroscopic regularities of the particle movement and guide the numerical simulation of the particle motion based on the Monte Carlo method. The particle distribution snapshots, residence time distribution (RTD) and mixing obtained from both the CFD-DEM and the MCM are compared. Results show that the computational speed of the MCM is faster than that of the CFD-DEM by about 2 orders of magnitude, and the difference of the mean particle residence time calculated by the two models is less than 2%. Besides, the MCM can well describe the time-averaged particle mixing compared to the CFD-DEM.
The Impact of Computerized Accounting Information System on the Performance of SMS Business Enterprises in Burao District
Authors: Ahmed Mohamed Saed
Published: July 2024

This study established a relationship between computerized accounting information systems (CAISs) and performance of SMS business enterprises in Burao, Somaliland. The main three objectives of this study were; (1) to assess the impact of computerized accounting information System on the performance of SMS business enterprises in Burao. (2) To measure the role of CAIS in the control system and management performance of SMS business enterprises in Burao. (3) To measure the impact of CAIS on the financial and operational performances in SMS business enterprises in Burao. The research approach of the study was quantitative research approach. The data used in this study was primary data obtained from the results of questionnaire survey on respondents. It was also utilized secondary data from the national documents, reports, different books, published materials and websites on the topic under the study. Using Slovene's formula, a sample size of 150 was used to collect data from respondents at SMS business enterprises in Burao through purposive sampling techniques. The data was analyzed through use of descriptive and inferential statistics. Reliability test and Validity test were also employed to test consistency of the measure and validity of data collected. The research findings indicated that there is a positive relationship between CAIS and the Performance of SMS business enterprises in Burao. This study recommended that SMS business should take advantage of the excellent benefits derivable from the adaption of well-designed CAIS because this will help to achieve a high and acceptable standard of quality in the performance of their business operations. The Management of SMS business enterprises (using CAIS) will benefit from this study understanding the impact of CAIS on their business practices. The academic generation and researchers will also benefit from the study in terms of literature review in matters of computerized accounting systems. In other terms, this will act as a point of reference for other future researchers.
Attuned Empathy, ‘Battlefields of Social Belonging’, and Other Reflections on Studying Those Who Perpetrate Violence
Authors: Straus Scott
Published: July 2024

In his response, Scott Straus presents reflections on the contributions in this special issue. Straus focuses in particular on three main areas discussed in the special issue: demonstrating the value of an approach of what he calls 'attuned empathy'; highlighting the politicized nature of research on perpetrators; and innovating concepts for research in this field of inquiry.
Tracing The Trialectic: The Process and Influence of Three Laws in The Establishment of Religious Courts in Indonesia
Authors: Khalid MD Moh. Muafiqul , Hidayat Aldi , Juhri Muhammad Alan , Solehah Elvina Lintang
Published: July 2024

This article discusses the legal trialectic in establishing the Religious Courts in Indonesia. Since its establishment in 1882, the Religious Courts have not fully represented Islamic law as its primary source. To trace this trialectic, the author uses Ebrahim Moosa's theoretical framework of "transculturation, counterpoints, social imaginary, networks, and legal orientalism." For this purpose, the author proposes two problem formulations. First, what is the process of trialectic attraction between Islamic law, positive law, and customary law in the establishment of the Religious Courts? Second, what is the extent of the influence of positive and customary law in limiting the role of Islamic law? The author offers two novelties, namely methodological novelty in Indonesian Islamic studies, by adopting Ebrahim Moosa's theory. Finally, the conclusive novelty is that the Religious Court is not derived from Islam but from the trialectic of three laws. The practical contribution of this study is to re-question the roles of religious courts in formalizing and implementing Islamic law in Indonesia, with the hope that religious courts will become a dialectical space where Islamic law continues to develop so that it can make a practical contribution to contemporary Indonesian society.
Vivências, desafios e conquistas no processo de alfabetização de uma estudante da Educação Especial
Authors: Bortolini Tamily , Dal Pizzol Coelho Zanin Alexsandra Joelma
Published: July 2024

O presente artigo tem por objetivo relatar uma vivência, enquanto auxiliar educacional em uma Rede Municipal do Centro-Oeste Catarinense e graduanda do curso de Pedagogia do IFC -Instituto Federal Catarinense, no processo de alfabetização de uma estudante da Educação Especial, do Ensino Fundamental II, no ano de 2023. Para isso, realizou-se uma produção crítico-reflexiva dos fatos vivenciados com uma análise dos referenciais teóricos e metodológicos da educação. O debate apoiou-se em autores como Paulo Freire (1997); Ana Teberosky e Emília Ferreiro (1999) e Madalena Freire (2023), além de legislações como LDB – Lei de Diretrizes e Bases da Educação (1996), Constituição Federal da República (1988) e LBI – Lei Brasileira da Inclusão (2015). Este relato também convida à reflexão do quanto, muitas vezes, o conhecimento é limitado para os estudantes com necessidades especiais, pois embora a educação especial e inclusiva esteja garantida na LDB nº 9394/96, ainda é um grande desafio materializar esse direito no cotidiano escolar. Além disso, compreende-se a práxis pedagógica como uma ação inerente à prática docente, pois somente por meio dela, novos caminhos puderam ser construídos, caminhos que possibilitaram significativos avanços no processo de alfabetização da estudante, assim como, novos olhares para a Educação Especial.
Lethal effect of thiophene and phenol rich leaf extract from Ferula asafoetida on Dacus ciliatus (Loew)
Authors: Zamani Seyed Hasan , Khani Abbas , Mohammadpour Kazem , Mirshekar Ali
Published: July 2024

Studies were conducted to evaluate the toxicity of methanol (MeOH) extract from Ferula asafoetida Linn. (Umbelliferae) leaves on female adults and larvae of the lesser pumpkin fly, Dacus ciliatus (Diptera: Tephritidae). Direct-dip bioassays for larvae and topical bioassays for adults of fly were used to assess mortalities. Mortality increased significantly with rising concentrations. The intermediate lethal concentrations (LC50), calculated 7.3 mg/ml (7300 ppm) for larvae. The female adult LC50 was 409 µg/insect. The chemical composition of the isolated MeOH extract from Ferula asafoetida leaves was examined by gas chromatography-mass spectrometry. The major compounds were 2, 3, 4, 5-Tetramethyl thiophene (22.1%), Phenol, 3-pentadecyl- (21.2%) and Mono (2-ethylhexyl) phthalate (15.98%). The results suggested that the extract from the tested plant could be used as a potential control agent for this pest.
A Study of the Sorption of Heavy Metals from Aquatic Solutions by Sorbents Based on Cellulosic Waste
Authors: Izguttinova Aruzhan
Published: July 2024

This scientific research studies the sorption capacity of cellulose-containing sorbents based on fir sawdust in relation to zinc ions with a concentration of 0.01-0.05 mol/l. The content of cellulose in fir sawdust was determined. The sorption capacity of non-activated sawdust and modified with sodium hydroxide solutions of various concentrations is considered as sorbents. It was found that sorbents modified with 1.5M NaOH solution have the greatest sorption capacity. The maximum degree of extraction for these sorbents is observed for a concentration of 0.01 mol/l zinc ions and is 78.9%.
The toxicity of heavy metals has a negative impact on ecosystems as a whole, negatively affecting the life cycle of organisms ranging from microorganisms to animals. Increased toxic concentrations of heavy metals cause numerous negative effects in the human body. For example, long-term intake of high doses of zinc may increase the risk of developing Parkinson's disease. Therefore, water purification is an urgent step has to be used to preserve environmental sustainability.
The aim of this project is to study the process of sorption of zinc ions by cellulose-containing sorbents.
Hypothesis: The use of activated cellulose-containing waste can reduce the concentration of heavy metals, in particular zinc, in aqueous solutions.
Research stages: The main stages include: sampling and preparation for the analysis of fir sawdust; determination of the cellulose content in fir sawdust, production of activated sorbents and study of sorption processes using zinc solutions of various concentrations as an example, calculation of the degree of zinc extraction and construction of adsorption isotherms; analysis of experimental results.
Methods used to implement the project: theoretical – methods of analysis of literary sources; empirical–methods of observation, comparison, chemical methods of analysis; methods of mathematical data processing.
Practical significance: the use of cellulose-containing waste as a sorbent.
Degree of independence: The sorption capacity of cellulose-containing sorbents based on fir sawdust in relation to zinc ions with a concentration of 0.01-0.05 mol/l has been studied. The content of cellulose in fir sawdust was determined. It was found that sorbents modified with 1.5M NaOH solution have the greatest sorption capacity. The maximum degree of extraction for these sorbents is observed for a concentration of 0.01 mol/l zinc ions and is 78.9%.
Adaptive Compression Framework for Giga-pixel Whole Slide Images
Authors: Ahn Sangjeong , Lee Jonghyun , Bappy Dewan , Jeong Won-Ki , Lee Sung Hak
Published: July 2024

Digital pathology images require significant storage space, leading to high costs. To address this, compressing pathology images for storage and restoration has been proposed; however, this involves a trade-off between compression ratio and information loss. Traditional compression techniques often apply a uniform compression ratio, ignoring the variable informational content across different slide regions (information disequilibrium). We proposed an Adaptive compression framework for giga-pixel whole Slide images, namely AdaSlide, overcomes this limitation by integrating a compression decision agent (CDA) and a foundational image enhancer (FIE), enabling adaptive compression decisions aware of information disequilibrium. The CDA uses reinforcement learning to assess each patch's necessity and degree of compression, ensuring minimal information loss and maintaining diagnostic integrity. The FIE, trained on diverse cancer types and magnifications, guarantees high-quality post-compression image restoration.

The FIE's performance was evaluated using a visual Turing test, where pathology experts could barely distinguish between real images and compressed-restored images (55% accuracy, coincidence level: 50%). In six downstream tasks (including patch-level classification, segmentation, and slide-level classification), AdaSlide maintained the prediction performance of the original images in five out of six tasks. In contrast, traditional methods with a uniform compression ratio only maintained performance in two out of six tasks, raising concerns about information loss. Additionally, AdaSlide could store data using less than 10% of the original WSI size. This indicates that, unlike traditional methods, AdaSlide can efficiently compress data while preserving clinically significant information. Furthermore, AdaSlide provides flexibility with its study objective-oriented reward function, compression tendency, and FIE backbone architectures. This adaptive approach ensures efficient storage and retrieval, potentially transforming the management of digital pathology data storage systems by aligning compression strategies with clinical relevance, thereby facilitating both cost reduction and improved diagnostic processes.
Multi-objective optimization of the structural parameters of an allmetal progressive cavity pump based on Grey-Taguchi relational analysis
Authors: zhou jing , xie jie , lu lin , sun wenbin
Published: July 2024

The all-metal progressive cavity pump (AMPCP) lifting technology can effectively address the challenge of efficiently lifting heavy-oil wells with steam throughput hot recovery. However, design issues have been found to reduce the volumetric efficiency and stability of AMPCP during the process of heavy-oil hot recovery. To enhance the volumetric efficiency and head of the AMPCP, as well as to minimize the impact of turbulent kinetic energy, the Taguchi method was employed to conduct a total of 25 orthogonal experiments involving four factors at five levels. The input parameters included the rotor radius, eccentricity distance, meshing clearance, and the helical pitch of the stator. The output parameters consisted of volumetric efficiency, head, and turbulent kinetic energy. The single-factor effects were analyzed using signal-to-noise ratio (SNR), range analysis (R/S), and variance analysis (ANOVA). Employing the Taguchi method combined with grey relational analysis, the three response objectives were combined into a gray relational grade (GRG). The structural parameter combination that conforms to 95% volumetric efficiency is as follows: rotor radius of 20.5mm, eccentricity distance of 5.1mm, meshing clearance of 0.35mm, and the helical pitch of the stator of 135mm. The simulation results indicate that utilizing Taguchi's method and gray relational analysis for the structural design of AMPCP can enhance its volumetric efficiency and stability.