bluuebunny/crossref_metadata_2025 huggingface dataset:
High glucose-induced inhibition of osteoblast like MC3T3-E1 differentiation promotes mitochondrial perturbations
Authors: Medeiros Claudia , Wallace Joseph M.
Published: June 2022

Diabetes mellitus is a metabolic disorder that causes health concerns worldwide. Patients with diabetes exhibit multisystemic symptoms, including loss of bone quality over time. The progressive deterioration of bone promotes failure to withstand damage and increases the risk of fractures. Much of the molecular and metabolic mechanism(s) in diabetic bone remains unclear. In vitro studies suggest that hyperglycemia inhibits mineralization, affecting bone formation and function. In this study, inhibition of osteoblast differentiation was induced using hyperglycemia to assess whether high glucose promotes mitochondrial impairment along with altered bone matrix formation. It was hypothesized that bone energy metabolism would be altered in these cells as calcium deposition, a key phase for bone function, is suppressed. Early passages of osteoblast like MC3T3-E1 cells were differentiated under normal and high glucose conditions. To investigate osteoblast differentiation, we quantified calcium accumulation by alizarin red staining and analyzed immunoblots of key proteins. To assess mitochondrial function, we quantified mitochondrial DNA (mtDNA), detected expression and function of key proteins from the Tricarboxylic (TCA) cycle, measured mitochondrial respiration, and fuel oxidation of alternative nutrients. Results confirmed previous work showing that mineralization was inhibited and AKT expression was reduced in high glucose-treated bone cells. Unexpectedly, high glucose-treated osteoblast cells utilize both mitochondrial respiration and glycolysis to maintain energy demands with partial help of fatty acid for reliance of baseline bioenergetics. These metabolic shifts suggest that hyperglycemia maintain bone metabolic needs in an early differentiated state concurrent to the inhibition in bone matrix formation.
A machine learning approach to identifying important features for achieving step thresholds in individuals with chronic stroke
Authors: Miller Allison E. , Russell Emily , Reisman Darcy S. , Kim Hyosub E. , Dinh Vu
Published: June 2022

Background

While many factors are associated with stepping activity after stroke, there is significant variability across studies. One potential reason to explain this variability is that there are certain characteristics that are necessary to achieve greater stepping activity that differ from others that may need to be targeted to improve stepping activity.

Objective

Using two step thresholds (2500 steps/day, corresponding to home vs. community ambulation and 5500 steps/day, corresponding to achieving physical activity guidelines through walking), we applied 3 different algorithms to determine which predictors are most important to achieve these thresholds.

Methods

We analyzed data from 268 participants with stroke that included 25 demographic, performance-based and self-report variables. Step 1 of our analysis involved dimensionality reduction using lasso regularization. Step 2 applied drop column feature importance to compute the mean importance of each variable. We then assessed which predictors were important to all 3 mathematically unique algorithms.

Results

The number of relevant predictors was reduced from 25 to 7 for home vs. community and from 25 to 16 for aerobic thresholds. Drop column feature importance revealed that 6 Minute Walk Test and speed modulation were the only variables found to be important to all 3 algorithms (primary characteristics) for each respective threshold. Other variables related to readiness to change activity behavior and physical health, among others, were found to be important to one or two algorithms (ancillary characteristics).

Conclusions

Addressing physical capacity is necessary but not sufficient to achieve important step thresholds, as ancillary characteristics, such as readiness to change activity behavior and physical health may also need to be targeted. This delineation may explain heterogeneity across studies examining predictors of stepping activity in stroke.
Increased risk of venous thromboembolism in patients with granulomatosis with polyangiitis: A population-based study
Authors: Marozoff Shelby , Mai Alice , Dehghan Natasha , Sayre Eric C. , Choi Hyon K. , Aviña-Zubieta J. Antonio
Published: June 2022

We assessed the risk and time trends of venous thromboembolism (VTE) including pulmonary embolism (PE) and deep venous thrombosis (DVT) in new granulomatosis with polyangiitis (GPA) cases compared to the general population. Using a population-level database from the entire province of British Columbia, Canada, we conducted a matched cohort study of all patients with incident GPA with up to ten age-, sex-, and entry time-matched individuals randomly selected from the general population. We compared incidence rates of VTE, PE, and DVT between the two groups, and calculated hazard ratios (HR), adjusting for relevant confounders. Among 549 individuals with incident GPA (57.6% female, mean age 55.4 years), the incidence rates for VTE, PE, and DVT were 7.22, 2.73, and 6.32 per 1,000 person-years, respectively; the corresponding rates were 1.36, 0.74, and 0.81 per 1,000 person-years among the 5,490 non-GPA individuals. Compared with the non-GPA cohort, the fully adjusted HRs among GPA patients were 2.90 (95% CI, 1.10–7.64), 4.70 (95% CI, 1.74–12.69), and 1.66 (95% CI, 0.52–5.27) for VTE, PE, and DVT, respectively. The risks of VTE, PE, and DVT were highest during the first year after GPA diagnosis with HR (95% CI) of 11.04 (1.37–88.72), 26.94 (4.56–159.24), and 2.68 (0.23–31.21), respectively. GPA patients are at significantly increased risk of PE, but not DVT. Monitoring for these complications is particularly warranted in this patient population, especially early after diagnosis.
Monitoring occurrence of SARS-CoV-2 in school populations: A wastewater-based approach
Authors: Castro-Gutierrez Victor , Hassard Francis , Vu Milan , Leitao Rodrigo , Burczynska Beata , Wildeboer Dirk , Stanton Isobel , Rahimzadeh Shadi , Baio Gianluca , Garelick Hemda , Hofman Jan , Kasprzyk-Hordern Barbara , Kwiatkowska Rachel , Majeed Azeem , Priest Sally , Grimsley Jasmine , Lundy Lian , Singer Andrew C. , Di Cesare Mariachiara
Published: June 2022

Clinical testing of children in schools is challenging, with economic implications limiting its frequent use as a monitoring tool of the risks assumed by children and staff during the COVID-19 pandemic. Here, a wastewater-based epidemiology approach has been used to monitor 16 schools (10 primary, 5 secondary and 1 post-16 and further education) in England. A total of 296 samples over 9 weeks have been analysed for N1 and E genes using qPCR methods. Of the samples returned, 47.3% were positive for one or both genes with a detection frequency in line with the respective local community. WBE offers a low cost, non-invasive approach for supplementing clinical testing and can provide longitudinal insights that are impractical with traditional clinical testing.
Men, War and Film
Authors: Hawley Steve
Published: June 2022

The Calling Blighty series of films produced by the Combined Kinematograph Service produced towards the end of the Second World War were one-reel films in which soldiers gave short spoken messages to the camera as a means of connecting the front line and the home front. These are the first ever films where men speak openly in their regional accents, and they have profound meaning for remembrance, documentary representation and the ecology of film in wartime.

Of the 400 films (or ‘issues’) made, 64 survive. Each of those contained around 25 individual messages. Men – and a very few women - from a particular city, town or region were grouped together for the films to make regional screenings back in UK cinemas and town halls possible. Personnel from all three services are featured, but the men are predominantly from the army units. Screenings took place at a cinema in the subjects’ local area and were usually organised by the regional Army Welfare Committee. The names and addresses of those to be invited to the screenings were sent to the UK along with the films.

Until now, these films have barely been researched, and yet are a valuable source of social history as well as representing a different mode from the mainstream of British wartime documentary. This book expands the history of Calling Blighty and places it in a broader context, both past and present. New research reveals the origins of the film series and draws comparisons with written and oral contemporary sources.

Steve Hawley is an artist/filmmaker whose work has been screened worldwide, and has collaborated closely with the North West Film Archive UK. He is emeritus professor at the Manchester Metropolitan University UK.

Using memoirs and diaries, Steve Hawley has researched the roles in the Burma campaign of participants in the surviving films, and traced over 160 of the families of the men – and two men still alive – and recreated these wartime screenings.

Hawley’s book is part description of the films, part reclamation of a largely unknown genre of wartime filmmaking, partly an account of the Burma campaign, and partly a discussion of war and memory. Engagingly and warmly written.

It will be of interest to scholars and researchers in the areas of war studies, especially those specializing in the social rather than military history of warfare, and historians of British wartime cinema and documentary. Also useful for an undergraduate audience, in history, media/film studies.

Potential for readers with an interest in the Second World War, particularly the war in Burma, and those with an interest in family history of the period.
El alcance del derecho de huelga en contextos de externalización productiva
Authors: RUIZ SAURA JOSÉ ENRIQUE
Published: June 2022

Desde finales del siglo pasado, la doctrina y la jurisprudencia han venido perfilando los límites legales de las nuevas prácticas empresariales dirigidas a anular los efectos del ejercicio de la huelga, todas ellas comprendidas en el concepto de esquirolaje. La actual regulación de este derecho fundamental es escasa y data del año 1977. Esto implica que, para clarificar el criterio judicial aplicable ante realidades laborales novedosas como es la descentralización productiva, se hace necesario un repaso de la evolución y la consolidación de la jurisprudencia surgida tras la llegada de estas tendencias a la economía de nuestro tiempo. De ello, puede extraerse que los tribunales han pasado de censurar únicamente la sustitución de huelguistas por trabajadores ajenos a la empresa (esquirolaje externo) a declarar contrarios a Derecho otros tipos no recogidos expresamente en la norma, como es la sustitución de huelguistas por trabajadores pertenecientes a empresas contratistas.
INTANGIBLE ASSETS EVALUATION : SYSTEMATIC AND SCIENTIFIC VALIDATION AT ITAIPU TECHNOLOGICAL PARK – PTI BRAZIL
Authors: Hoss Osni
Published: June 2022

Objective: This research aims to systematize the evaluation of intangible assets, which serve as a subsidy in the decision-making process in the value management of companies, while the problem that this research aims to answer is how to evaluate companies with a focus on intangible assets.
Method:  The approach of this research is managerial. Descriptive statistical analysis tools were applied used as measures of association of intangible assets variables. The scientific validation was developed in section 5 at the Itaipu Technological Park: overview of the methodology, objectives and issues; field procedures (access to the locations of information sources and formation of a competence cell); evaluation questions (application of the systematic developed in topic 4); guide for reporting the study and then presenting the results obtained.
Results: One of the knowledge gaps, addressed in this research, reveals the scientific finding to evaluate intangible assets in non-profit organizations at the Itaipu Technological Park - PTI, which showed the value of 1.05 billion while accounting presented its total assets with 221.1 million.
Contributions: The contributions were the discovery of flaws in the models that evaluate intangible assets as being the difference between market and book value, as well as the existence of an interrelated dependence on intangible assets due to its value being closely linked with the conditions necessary for the generation of wealth in terms of people, processes, structure and relational as market factors, also the systematization of the evaluation of intangible assets for non-profit organizations.
Keywords: Intangible assets, evaluation, value added.
AGENT-BASED MODEL AND MANAGEMENT ACCOUNTING: CULTURE-CONTINGENT MANAGERIAL BEHAVIOR IN LIGHT OF BUDGETARY CONSTRAINTS
Authors: Cornacchione Edgard , Reginato Luciane
Published: June 2022

Objective: The paper aims at creating a model to simulate managerial behavior within a budgetary process affording analysis of evolving overall performance and specific behavioral attributes, at both firm- and manager-level.Method:  This study focuses on computer science, decision systems and management, by exploring agent-based modeling (ABM) in management accounting, with Python and Mesa. The model adopts a Consumer Service Provider firm and its quarterly sales budgeting process for a network of 400 branches over a 5-year term, contingent to firm culture (authoritarian or participative).Results and discussions: Data analytics yielded results based on intense model simulation, with more than 19 million data points. Findings show culture-contingent firm performance and managerial behavior evolution linked to the budgetary process. Authoritarian firms generated fair more sales with similar managerial human capital  and market, under increasing strong demand; authoritarian firms paid more bonuses as part pf their reward system. In general, an authoritarian culture may benefit in a strong demand scenario thad participative firms, potentially due to budgetary slack form negotiation. On the other hand, authoritarian forms showed lower levels of happiness and engagement among their managers. Contributions: Contributions are threefold, pointing to (a) management accounting practice and research, (b) science and research strategy, and (c) accounting education.
EMPRESAS GERENCIAM LUCROS TRIBUTÁVEIS E CONTÁBEIS SIMULTANEAMENTE EM TEMPOS DE CRISE?
Authors: Tardin Neyla , De Oliveira Wilson Luis
Published: June 2022

Objetivo: Este trabalho investiga se as empresas brasileiras se envolvem simultaneamente em práticas de gerenciamento de resultados via accruals discricionários e de agressividade tributária em períodos de crise econômica.
Método: A amostra foi composta por 2.301 observações de 142 empresas não financeiras com ações negociadas na B3 S/A, entre os anos de 1998 e 2019. Os dados foram coletados na base Economática®.
Resultados: Os achados evidenciam que, em períodos de crise, empresas se envolvem mais em agressividade tributária para melhorar fluxo de caixa e pagar menos tributos. Além disso, as empresas gerenciam mais resultados contábeis para baixo durante crises, pois o mercado tolera baixo desempenho financeiro nesses períodos. Não há evidências de que as empresas se envolvem em gerenciamento de resultados contábeis e em agressividade tributária simultaneamente em tempos de crise econômica, uma vez que essa manobra aumenta o custo ou o risco da transação perante os órgãos regulatórios.
Contribuições:  Os achados possuem implicações práticas para observação dos órgãos reguladores, de que empresas que adotam conduta agressiva em economia de impostos não tendem a manipular seus lucros em um mesmo período, estratégia possivelmente explicada pelo risco envolvido nas operações.
Hubungan Beban Kerja dengan Kompetensi Sosial Guru Madrasah Ibtidaiyah Al-Ma'had An-Nur
Authors: Purnairawan Riski Eka , Janah Septa Miftakul
Published: June 2022

The teacher's workload is a work demand that must be done by the teacher professionally and well. On the other hand, teachers must have competent competencies, one of which is social competence. These competencies require teachers to relate harmoniously with students, colleagues at school, and the community where they live. The purpose of this study is to find out how the relationship between the workload received by the teacher and the social competence of a teacher. The research method used is field research with 21 respondents from Madrasah Ibtidaiyah Al-Ma'had An-Nur teachers with an angle distribution technique. The results obtained that the significance value (sig) of the workload variable (X) is 0.748 with a sig value of 0.748 > greater than the probability of 0.05 which means H0 is accepted and H1 is rejected.
The Merdeka Belajar Kampus Merdeka Program: An Analysis of the Success Factors
Authors: Defrizal Defrizal , Redaputri Appin Purisky , Narundana Vonny Tiara , Nurdiawansyah Nurdiawansyah , Dharmawan Yanuarius Yanu
Published: June 2022

The background of this research is that the implementation of the MBKM policy has not been fully implemented, obstacles such as human resources and supporting facilities are not yet ready. So, it is necessary to know what are the factors that influence the successful implementation of Merdeka Belajar Kampus Merdeka Program, especially at the Universitas Bandar Lampung. This study uses a qualitative approach with data collection methods using In-Depth Interviews. The results obtained are the factors that influence the success of the implementation of the Merdeka Belajar Kampus Merdeka Program, namely the commitment and vision of the university leadership towards the implementation of the Merdeka Belajar Kampus Merdeka Program, the existence of a special unit that is responsible for the implementation of the Merdeka Belajar Kampus Merdeka Program, the support and commitment of partners, the same positive mindset from the entire academic community regarding the Merdeka Belajar Kampus Merdeka, the role of active and optimal supervisors, the role of active, initiative and creative students, the role of other academics regarding the administration of activities, the existence of standard operating procedures references, curriculum conformity planning, ect.
Proses Pembentukan Kompositum pada Nama Objek Wisata Cianjur sebagai Materi Ajar Tata Bahasa BIPA Dasar
Authors: Naufalia Afina , Wagiati Wagiati , Soemantri Ypsi Soeria , Kadir Puspa Mirani
Published: June 2022

This research is motivated by the uniqueness of naming tourist objects in Cianjur Regency which uses a lot of composites. The results of this study can be used as learning materials in BIPA learning. In BIPA learning, according to Permendikbud no. 27 of 2017, there is compound word material and tourism object material in competency element 6.5, so that the design of this grammatical material is sustainable. The method used in this research is descriptive qualitative. The result is that the names of tourist objects in Cianjur are mostly endocentric noun composites which are composed of noun+noun categories and are unequal composites. This data is classified into 8 parts, namely there are 26 composites which are composed of noun+noun categories and are unequal composites, namely compound words whose elements are not equal. This collection of tourist-themed composites can be used as teaching materials for BIPA 3.
Quality Management Strategy Based on Total Quality Management (TQM) Ibtidaiyah Madrasah Tahfiz El Muna Q Krapyak Yogyakarta
Authors: Muslim Muhammad Irfai , Syafii Ahmad
Published: June 2022

The issue of low and unsatisfactory service quality has prompted the public sector to carry out reforms in all fields. Various concepts, “ New Public Management,” which has proven its success in the private/business sector, are tried to be adopted and implemented. One of the quality management concepts widely applied in both the business and public sectors is TQM ( Total Quality Management). This study aims to explain the application of TQM-based quality management principles in MI Tahfidz El Muna Q (Madrasah Ibtidaiyah Tahfidz El Muna Q) Islamic boarding school Al-Munawwir Krapyak Yogyakarta. The type of research is qualitative research with a case study approach. Methods of collecting data by observation, interviews, and documentation. Data analysis using thematic analysis. Test the validity of the data using the triangulation test. The results show that MI Tahfidz El Muna Q has implemented the TQM principle with good. TQM-based quality management principles applied are quality assurance Institute, education/training carried out to improve the quality of elementary school M, customer-oriented, communication pattern, empowering educators and education staff, reporting to stakeholders, benchmarking against other institutions, understanding of the institution’s long-term goals, routine evaluation, and happiness. Based on these ten indicators, it can be understood that MI Tahfidz El Muna Q has carried out continuous improvement well.
Pembelajaran Jarak Jauh di Era Pandemi Covid 19: Studi Terhadap Pembelajaran PAI di Kelas VIII SMP Islam Prestasi Al Mubtadi-Ien
Authors: Mujib Muhamad , Rizal Dimas Ahmad
Published: June 2022

This research is a descriptive qualitative study, which explains a recent phenomenon through open interviews to examine and understand the events that occurred during the implementation of Distance Learning (PJJ) at Al Mubtadi-Ien Islamic Junior High School, Bantul during the Covid 19 pandemic. The results showed that the selection of the lecture method as an effective learning method to be applied in distance learning in class VIII Islamic Junior High School Prestasi Al Mubtadi-Ien. Several stages that must be considered in the use of the lecture method are conveying the learning objectives, adjusting the accuracy of the method, managing the attention and condition of students, presenting material, providing conclusions, and conducting evaluations. The use of the lecture method in distance learning of Islamic Religious Education at SMP IP Al Mubtadi-Ien, especially in class VIII emphasizes students' understanding of the material presented by the teacher, with the help of additional platforms to optimize the teaching and learning process
Infrapolitiques des paniques morales : faire face et faire sens de « la guerre du loup »
Authors: Doré Antoine , Nicolas Frédéric
Published: June 2022

En nous intéressant à la panique morale à laquelle donne lieu le retour du loup, nous montrons que les paniques morales n’ont pas pour seuls effets d’entraîner le débat public et d’enclencher des processus réglementaires et législatifs en même temps que des formes de contrôle social, mais qu’elles ont des effets sur ceux qu’elles désignent comme déviants ou immoraux. Ces effets se donnent à voir dans l’exercice des métiers d’éleveurs et de gardiens de troupeau, mais également dans le cadre de sociabilités extra-professionnelles au sein de l’espace social localisé et de la maisonnée. Si les professionnels du pastoralisme ne sont pas dépourvus de ressources pour tenter de renverser le stigmate de la panique morale, nous montrons néanmoins que celle-ci donne davantage lieu à des formes ordinaires de résistance qui consistent à se ménager une forme de quant-à-soi ou de chez-soi.
Perancangan Perahu Pemungut Sampah Plastik yang Mengapung di Pesisir Danau Matano
Authors: Harman Harman , Jasman Jasman , Israkwaty Israkwaty
Published: June 2022

Sampah plastik yang menumpuk di pesisir danau Matano merupakan akumulasi dari perilaku masyarakat selama bertahun-tahun membuang sampah di sembarang tempat yang pada akhirnya terbawa air ke Danau Matano. Diperlukan upaya bersama antara masyarakat dan pemerintah daerah guna menanggulangi penumpukan sampah tersebut. Meskipun telah dilakukan upaya pembersihan, namun penumpukan sampah masih terlihat di beberapa titik. Salah satu kendala karena sulitnya menjangkau area yang berada di air yang bercampur lumpur, serta keberadaannya di bawah rumah-rumah warga setempat.  Tujuan penelitian ini adalah merancang perahu yang dapat menjangkau area penumpukan sampah di air, serta mengangkat sampah tersebut ke atas perahu secara otomatis menggunakan metode pembanding. Hasil yang diperoleh berupa gambar rancangan menggunakan software Autodesk Inventor yang siap dilakukan proses Fabrikasi dengan ukuran utama 3740 x 2000 x 800 (L x B x D). Pengujian dilakukan melalui analisis berat yaitu sebesar 179,97 kg, dengan gaya apung sebesar 606,53 kg, sedangkan volume lambung yang akan tenggelam ketika berada pada kapasitas maksimal sebesar 79,13%. Dari hasil tersebut, perahu akan dapat berfungsi sebagaimana yang diharapkan.  A piled of plastic waste has been seen across the shore of Lake Matano. This has become the results of local people’s bad behavior for years for not throwing their garbage to its place. Those waste has been carried by the stream and forms such a disturbing plastic pile along the shore, and had raised some environmental concerns over this behavior. Therefore, this requires serious attention particularly from the community and local government for solution. There have been some actions taken for trying to solve it, however, similar pile is still found in some hotspots. There has been some limitation to those actions, for example to reach areas under the water that has already been mixed with muds for a long time, and those which has been stack under houses of the local’s residents. This research aimed at designing a garbage boat that shall able to collecting the waste, particularly plastic in some difficult hotspots mentioned above automatically by the use of a comparison method. The result is a drawing design generated by the Autodesk Inventor software which is ready for next step, the fabrication process. The main dimension of the boat is 3740x2000x800 (L x B x D). A test was done specifically on the weight of the boat which approximately 177.97kg, with a buoyancy force of 606,53 kg, Then the volume for the hull part would sink whenever reach its ‘capacity of 79,13%. Under this current estimation, the whole part is ready for operation.
Kiss me (not!), Cressida – Or: The social touch of lips and tongue
Authors: Ungelenk Johannes
Published: June 2022

The article is dedicated to the problem of social bonds that is negotiated in Troilus and Cressida. Troilus and Ulysses embody an old, traditional order of the world that is out of joint, while Cressida’s behaviour and her way of interacting indicate a different and new regime of social regulation that is about to take over. With its complex superposition of (touches of) love and war, Troilus and Cressida brings together rituals of touch, anarchic speech acts, and a gendered perspective on the world that associates touch and temporality with ‘frail’ femininity and temptation. With unrivalled intensity, the play puts to the spectator that the basic condition of touch, i. e. exposing oneself to another, entails an incalculable risk. Hector tragically falls for the vulnerability inherent in touch and the audience suffers with him because they share this existential precondition on which modern society is ‘founded.’ The gloomy, inescapable atmosphere of societal crisis that Troilus and Cressida creates emphasises the fact that the fragility of touch is not to be overcome. The fractions – no matter whether Greek, Trojan, or those of loving couples – cannot simply be reunited to form a new, authentic entity. Generating at least some form of social cohesion therefore remains a challenge.
Where have all the sound changes gone? Phonological stability and mechanisms of sound change
Authors: Bowern Claire
Published: June 2022

When do the mechanisms of regular sound change fail to apply? What types of languages and situations exhibit and promote phonological stability? I consider these questions using data from the languages of Aboriginal Australia, where there has been debate on this question. I show that the standard explanations are inadequate, and possible solutions have not yet been empirically investigated. Given how many of these languages are already either no longer spoken or severely under threat, it is important to investigate these questions urgently.
Antitumor activity of recombinant oncolytic vaccinia virus with human IL2
Authors: Liu Liqiong , Li Huiqun , Xu Qinggang , Wu Yan , Chen Dongfeng , Yu Feng
Published: June 2022

The tumor microenvironment is highly immunosuppressive. The genetically modified oncolytic vaccinia virus (OVV) is a promising vector for cancer immunotherapy. The aim of the present study was to assess the antitumor effects of human interleukin-2 (hIL2)-armed OVV in vitro. The hIL2 gene was inserted into a thymidine kinase and the viral growth factor double deleted oncolytic VV (VVDD) to generate recombinant hIL2-armed OVV (rVVDD-hIL2). Viral replication capacity in A549 cells was quantified by plaque titration on CV-1 cells. Production of hIL2 in cancer cells infected by rVVDD-hIL2 was measured by enzyme-linked immunosorbent assay. Finally, 3-(4,5-dimethylthiazol-2-yl)-5-(3-arboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium, inner salt (MTS) assay was performed to assess the antitumor effects of rVVDD-hIL2. The results showed that rVVDD-hIL2 viral particles expressed increasing levels of hIL2 in human and murine cancer cell lines with growing multiplicities of infection (MOIs). The insertion of the hIL2 gene did not impair the replication capacity of VV, and the rVVDD-hIL2 virus killed cancer cells efficaciously. The lytic effects of the recombinant oncolytic virus on tumor cells increased with the growing MOIs. In conclusion, these findings suggest that hIL2-armed VVDD effectively infects and lyses tumor cells, with high expression of hIL2.
Our Unlimited Possibility To Adapt
Authors: Kuman Maria
Published: June 2022

All created forms, from the single cell to the most complex organism (of plants, animals, or humanoids) were endowed with unlimited possibility to adapt. We are not even aware how far these adapting abilities can reach. Dzasmuchin is a woman living in Australia [1], who is not eating or drinking since 1993. She is author of many books and articles. She is advocate of living with the energy of the sun without eating and drinking. Similar is Zinaida, living in South Russia [1]. It took one and a half month for Zinaida to adapt to not eating and drinking, but investigation of her body showed that now her anatomy is totally different from the anatomy of people who eat and drink. These two women live with the energy, which their bodies receive from the environment, and utilize this energy at cellular level [1].
Refratory Asma – A Case Of Humoral Immunodeficiency
Authors: monteiro Md. Fabrício prado
Published: June 2022

RFM, 9 years old, referred for allergy assessment due to frequent visits to the infantil hospital presents with a history of recurrent pneumonia, sinusitis and otitis. It has associated atopy and during follow-up evaluations in Allergy showed diagnosis of mild persistent asthma. We started prophylactic treatment with corticosteroid pulmonary action and beta 2 agonist of long duration. Although adequate management with quarterly visits to the allergy ambulatory, therapeutic adherence by family members, correct use of medications and understanding of the pathology in question, treatment refractoriness occurred. New reclassification of the level of mild persistent asthma.
Bacterial Community Structure of Fermenting Grains in Fen Wine
Authors: Zhen Pan , Yue Ke , Xu Mengke , Jiang Jihong
Published: June 2022

Fen wine is a typical representative of Daqu Fen-flavor liquor with traditional solid-state separation fermentation and secondary pure-steaming technology. Due to the non-sterile and open solid-state fermentation procedure, the bacteria community involved exhibit a high complexity. This makes it difficult to control the fermentation process, which is critical to the overall quality and taste of the Fen wine. In this study, we applied the Illumina MiSeq to characterize the overall bacteria species during the fermentation of grains. The results showed the changes of bacteria community structure, including the number of species and their relative quantity, which will help to standardize the fermentation procedure and provide a valuable quality control standard. Key words: Fen Wine; Fermenting Grains; Bacterial Diversity; High- Throughput Sequencing
Byron and the Problem with Memory Arts
Authors: Rexroth Grace
Published: June 2022

Grace Rexroth, “Byron and the Problem with Memory Arts: Writing Don Juan for an Age of ‘Uncertain Paper’” (pp. 1–28)

In the first canto of Don Juan (1819–24), George Gordon, Lord Byron describes Juan’s mother as a woman whose memory needs no artificial aid: “Her memory was a mine. …For her Feinagle’s were an useless art.” The mention of “Feinagle” is a reference to a memory system designed by Gregor von Feinaigle, outlined in a book titled The New Art of Memory (1812). While the reference might appear insignificant, I argue that concerns about memory and mnemonic arts actually animate Byron’s poem. I view Feinaigle as a touchstone for a set of memory practices that proliferated into what Blackwood’s Edinburgh Magazine would later decry as an “explosion of mnemonics.” As the print landscape of the Regency era rapidly expanded, such systems promised to help readers deal with the resulting information overload by helping them to remember everything they read. Set within this context, Don Juan seems to respond to the same anxieties that animated the fad for mnemonics. However, rather than attempting to help readers remember everything, Byron foregrounds the question of what should be remembered and why—especially when it comes to memorializing war. In this way, Don Juan becomes an alternative Romantic memory palace animated by a cultural anxiety about how to read and recall what the powers-that-be would have us forget.
Authorship, Authenticity, Authority: Evaluating Aristotle’s Rhetoric and Poetics
Authors: Kirby John T.
Published: June 2022

This essay explores a nexus of related concepts—authorship, authenticity, and authority—as they impinge upon one another and on the experience of reading, particularly in the case of “canonical” authors such as Aristotle. Aristotle’s own Rhetoric and Poetics are considered together in light of these concepts, as well as in terms of seven constraints that operated upon Aristotle as a thinker and writer. Twentieth-century theories of reading are adduced in an examination of the rhetorical dimensions of Aristotle’s own notion of authorship. The essay also examines the rhetorical forces entailed in the editing and publication of authors known only from ancient manuscripts, and in the reading of legal and sacred texts.
Quantitative aspects of estrogen metabolism in mammalian female and male reproductive systems
Authors: Raeside James I
Published: June 2022

Although the role of estrogens in development and function of tissues in reproductive and other systems has long been recognized, their relative concentrations in target tissues have received scant attention. In this regard the significance of local metabolism of estrogens is clearly shown by incubation of tissues with radiolabeled estrogens.
The role of the Russian Orthodox Church in the integration of the Eastern Caucasus into the Russian cultural space during the Caucasian war (with the example of the left wing of the Caucasian cordon line)
Authors: Gasanov Magomed , Gazieva Abidat
Published: June 2022

The article is devoted to the experience of the Russian Orthodox Church in the fortresses and fortifications of the Left Wing of the Caucasian Cordon Line. During the study of the available literature and sources available to us, it was revealed that the missionary activity of the Russian Orthodox Church (ROC) was based on the principles of tolerance towards local peoples and Islam. Analyzing the activities of the ROC on the cordon Line, it is worth noting that initially churches on the Line were erected as regimental ones, with military units - to maintain moral and ethical values among Orthodox soldiers. The Russian government, at the founding of the first fortresses of the Caucasian Line, saw cordon fortifications as the agony of confrontation, which, in their opinion, could only be used as a dividing line between the troops and the highlanders. At the beginning of the 19th century, the fundamental idea of Caucasian politics changed and the policy was transformed from defensive to civilian colonization of the region, where the activities of the church were presented more than just overseeing and observing the spiritual needs of military personnel on the Line. The churches, both civil and military, participated in the complex process of acculturation in the region, where, by means of their functioning, they pushed the boundaries of the idea and perception of the mountaineers about Russia, carried out missionary activities in spreading Orthodoxy on the Lines, supported the ritual and everyday life of the Orthodox population of the region - civil and military. The activities of the Russian Orthodox Church extended to the issues of the dissemination of education, which in general had a positive trend for the region. In the fortifications and fortresses of the Left Wing of the Caucasian Cordon Line, the activity of the ROC was relative, in comparison with the Right Wing of the Line. This was due to the fact that the main concentration of the Orthodox population was concentrated there.
Bishop Jeremiah (Soloviev) as a compiler of akathists
Authors: Sidneva Maria
Published: June 2022

The article is dedicated to the Russian bishop of the XIX century, Bishop Jeremiah (Soloviev) (1799-1884) as the compiler of akathists, who wrote an akathist to the Monks Anthony and Theodosius and other Kiev Pechersk wonder-workers in the 60-70s of the XIX century, as well as an akathist to the Guardian Angel. These texts preserved in several manuscripts were never published and did not become the subject of special scientific study. The author attempts to look at the social aspect of the phenomenon of the Orthodox Russian akathist of the 18th and early 20th centuries using the example of the life of one of the authors of the akathists. The research is aimed at elucidating the motives behind the writing of akathists, at finding the place of Bishop Jeremiah among other akathistographers, studying akathists in the context of the entire literary work of the spiritual writer and tracing the functioning of his texts. On the basis of archival materials, the facts of the life of Bishop Jeremiah, which influenced his akathist work, connections and relations with other representatives of the circle of compilers of akathists, are reconstructed, and hymns belonging to him are analysed. The akathist work of Bishop Jeremiah is a vivid example of the hymnography of the "Learned Monasticism", in which more and more often a place was given to akathist writing in the Modern Times. The exclusive motivation for compiling akathists for Jeremiah was personal piety and veneration of individual saints, like most of Jeremiah's prayers, they were intended for personal use and a narrow circle of close people, but not for general church use. The stories about the traditions of composing and using akathists testify to the development of akathist culture in the Russian Church during the Synodal era.
The struggle for the journal "Russkoe obozrenie" in 1892
Authors: Medovarov Maksim
Published: June 2022

The article contains the first attempt to analyze systematically the reasons, driving forces and results of the struggle for the editorial office journal in 1892. The history of the study of the problem, the achievements and mistakes of contemporaries and historians is considered. The chronology of the conflict is being reconstructed on the basis of the censorship case of Russkoe Obozrenie and the extensive correspondence of dozens of actors. The role of Konstantin Leontiev’s death in rallying his students and associates around Tertiy Filippov and at the beginning of Nikolai Boborykin’s attempts to take away Russkoe Obozrenie from Prince Dmitriy Tsertelev is demonstrated. The role of the journal’s sponsor David Morozov, chief censor Yevgeny Feoktistov and other interested persons in these events is being clarified. There are revealed the reasons for the nomination of Anatoly Alexandrov, little-known at that time, to the new editor of Russkoe Obozrenie, as well as the circle of his supporters and opponents. There are considered the reasons for the refusal to transfer the journal to him at the end of August 1892 and the permission that followed a month and a half later to approve Aleksandrov as editor and publisher. Evidence of the participation of prominent dignitaries and outstanding publicists in the struggle for Russkoe Obozrenie is being introduced into scientific circulation. The position of the Main Directorate for Press Affairs, the Ministry of Internal Affairs, the Office of the Moscow Governor-General, Grand Duke Sergei Alexandrovich, are analyzed. Attention is paid to the struggle of Konstantin Pobedonostsev and Tertiy Filippov for influence on the new editorial office of the journal and its political course. The adherence to Leontiev’s ideas is shown as a key factor in the formation of the circle of the young editorial board (Anatoly Alexandrov, Vasily Rozanov, Lev Tikhomirov, Rev’d. Joseph Fudel and others).
A 12-Day-Old Female with Hypothermia, Hypoglycemia and Hyperbilirubinemia
Authors: Apsan Jennifer , Feuer Alexis J. , Modi Vikash K. , Cunniff Christopher , Lekarev Oksana
Published: June 2022

A 12-day-old, full-term female, born small for gestational age, presented to the emergency department with a 1-week history of worsening hyperbilirubinemia, intermittent hypoglycemia, and episodic hypothermia. The baby’s emergency department evaluation revealed transaminitis, pneumatosis intestinalis, indirect hyperbilirubinemia, and hypoglycemia. She was admitted to the ICU and received intravenous glucose, bowel rest, and phototherapy. Thyroid-stimulating hormone, thyroxine, and cortisol levels were low, and growth hormone was undetectable. The patient was hospitalized for a total of 19 days and was discharged from the hospital.
Persatuan Mahasiswa Islam Patani Thailand Indonesia (PMIPTI) Kota Padang Dalam Mempertahankan Eksistensi Budaya Melayu
Authors: Nofra Doni , Inggria Kharisma
Published: June 2022

PMIPTI adalah sebuah organisasi mahasiswa Patani Thailand yang ada di Indonesia, organisasi ini didirikan untuk menyatukan mahasiswa Patani yang menuntut ilmu ke Indonesia. Organisasi ini suda memiliki beberapa cabang di seluruh Indonesia, juga salah satunya di Kota Padang. Penelitian ini dilakukan untuk melihat usaha yang dilakukan anggota PMIPTI dalam mempertahankan budaya Melayu di Indonesia khususnya di Padang. Penelitian ini dilaksanakan berkaitan dengan hasil diskusi penulis dengan beberapa orang anggota PMIPTI Padang tentang kondisi keberadaan mereka di Indonesia khususnya di Padang, begitu juga berkaitan dengan kampung halamannya Thailand Selatan Patani. Keberadaan anggota PMIPTI di indonesia khususnya Padang, tidak hanya berkumpul-kumpul saja melainkan juga mencapai satu misi untuk mempertahankan budaya Melayu yang di Patani hari ini sudah banyak dihilangkan bahkan generasi muda Patani hari ini banyak yang tidak mengenal budaya Melayu yang merupakan jati diri Patani dahulunya. Mulainya hilang budaya Melayu di Patani salah satunya disebapkan oleh kebijakan pemerintahan Thailand yang ingin menghilangkan budaya Melayu yang pernah ada di Thailand. Salah satu usaha yang dilakukan pemerintah Thailand adalah melalui program pendidikan yang menggunakan bahasa Thai dalam kurikulumnya. Selain itu, anak-anak Patani sedikit sekali mendapatkan pencerahan berkaitan budaya Melayu. Untuk mempertahankan budaya Melayu Patani, PMIPTI Padang berusaha untuk mengulang dan mempelajari agar budaya mereka tetap bisa dipertahankan. Salah satu usaha yang dilakukan PMIPTI Padang adalah melakukan pembinaan bahasa Melayu bagi anggota PMIPTI, membudayakan berpakayan Melayu di setiap acara PMIPTI dan kegiatan lainnya. Kegiatan ini dilakukan PMIPTI padang agar mereka bisa mengetahui bagaimanabudaya mereka dahulunya sangat baik, namun hari ini sudah mulai hilang dan tidak ada lagi.
Self-praise by Chinese and American celebrities on TV talk shows
Authors: Li Fan , Wu Yicheng
Published: June 2022

Self-praise, a social practice that threatens the positive face of the addressee, is a relatively under-explored topic in politeness research. This article examines self-praise strategies used by Chinese and American celebrities. Based on an existing taxonomy of self-praise strategies, namely, explicit self-praise without modification, explicit self-praise with modification, and implicit self-praise, we collected data from two Chinese TV shows (Yang Lan Interview One on One and Jin Xing Show) and two American TV shows (The Ellen DeGeneres Show and The Charlie Rose Show). Through a detailed analysis of interactions between host and celebrity within Leech’s (2014) General Strategy of Politeness, it is found that there are four modification devices and three implicit frames in their self-praise. Additionally, American celebrities tend to praise themselves explicitly while Chinese counterparts always mitigate it. Cultural differences exhibited in the form of face-preserving needs and attitudes to the audience may account for preferences for different self-praise strategies in the two linguistic communities. The findings not only open a cross-cultural window to self-praise research but also offer insights into third-person politeness theorising.
Association between ultrasonographic parameters, clinical and biochemical indicators and results of surveys in patients with heart failure with moderately reduced left ventricle fraction
Authors: Rudyk Iurii , Babichev Denys , Medentseva Olena , Gasanov Iurii
Published: June 2022

The aim: to evaluate the probable impact of type 2 diabetes on quality of life, clinical, biochemical and ultrasonographic parameters in patients with HFwmrLVEF and associations between them.
Materials and methods: the study included 68 patients with HFwmrLVEF, including 36 patients with concomitant DM type 2 and 32 patients without type 2 DM, and 18 healthy individuals. All study participants underwent anthropometric (height, weight, BMI), laboratory (clinical blood test, biochemical blood test to determine ACT, ALT, creatinine, glucose, lipid spectrum, potassium, sodium and magnesium, ELISA to determine glycated hemoglobin and NT-proBN ), instrumental (EchoC, ECG) surveys and surveys to assess quality of life (EQ-5D-5L). Statistical processing of the obtained results was performed using the statistical software package SPSS v.19.0.
Results: between the group of patients with HFwmrLVEF with concomitant type 2 DM and the group with HFwmrLVEF without type 2 DM according to the results of the study there is a significant difference in quality of life in carbohydrate metabolism, NT-proBNP, BMI and echocardiographic data.
Conclusions: patients with HFwmrLVEF with concomitant type 2 DM compared with patients with HFwmrLVEF without type 2 DM had significantly worse carbohydrate metabolism, significantly higher mean serum NT-proBNP concentration, higher LVMM and iLVMM in transthoracic E quality of life according to the results of the EQ-5D-5L questionnaire in the absence of a significant difference in age and LVEF between groups. In addition, there was a stronger correlation between NT-proBNP and iLVMM in patients without type 2 DM and no correlation between NT-proBNP and LVMM in patients with concomitant type 2 DM, which may be due to certain influence of type 2 DM on the process of pro-BNP conversion