bluuebunny/crossref_metadata_2025 huggingface dataset:
Effects of Peroxide and Sulfur Curing Systems on Physical and Mechanical Properties of Nitrile Rubber Composites: A Comparative Study
Authors: Peidayesh Hamed , Nógellová Zuzana , Chodák Ivan
Published: December 2023

This study compares the effect of sulfur and dicumyl peroxide (DCP) vulcanizing systems on the physical and mechanical properties of rubber compounds based on acrylonitrile butadiene rubber (NBR). NBR compounds cured by different amounts of DCP and NBR vulcanizates filled with various concentrations of carbon black (CB) and a constant amount of sulfur or DCP were prepared. The vulcanizates were characterized by tensile testing, dynamic mechanical thermal analysis (DMTA), and cross-link density determination. The tensile strength and Young’s modulus were found to increase with the rising amount of DCP and CB, while elongation at break decreased. The samples vulcanized by the sulfur system and filled with CB show a substantial increase in tensile strength from 13.1 to 21.2 MPa. Higher storage modulus and glass transition temperature were observed with the increase in the amount of peroxide and filler, and consequently, the increase in cross-link density, indicating rigidity increase and lower molecular mobility. The changes in the physical and mechanical properties of the NBR vulcanizates were in correlation with the changes in solvent uptake and cross-link density.
Recycling Ophthalmic Lens Wastewater in a Circular Economy Context: A Case Study with Microalgae Integration
Authors: Encarnação Telma , Nicolau Nadia , Ramos Pedro , Silvestre Elsa , Mateus Artur , Carvalho Tomás Archer de , Gaspar Florindo , Massano Anabela , Biscaia Sara , Castro Ricardo A. E. , Nogueira Bernardo A. , Singh Poonam , Pacheco Diana , Patrício Tatiana , Fausto Rui , Sobral Abílio J. F. N.
Published: December 2023

Water pollution poses a global threat to ecosystems and human health and is driven by the presence of various contaminants in wastewater, including nano- and microplastics. Despite the magnitude of this problem, the majority of global wastewater is released untreated into water bodies. To combat this issue, a multi-strategy approach is needed. This study explores a circular economy-based solution for treating emerging pollutants, particularly wastewater from ophthalmic spectacle lens production. Our approach integrates solid waste materials into polymeric and cement matrices while also utilising wastewater for microalgae cultivation. This innovative strategy focuses on biomass generation and economic valorisation. By adopting a circular economy model, we aim to transform environmental pollutants from wastewater into valuable organic products. A key component of our approach is the utilisation of microalgae, specifically Nannochloropsis sp., known for its high lipid content and resilience. This microalgae species serves as a promising biobased feedstock, supporting the production of innovative biobased products, such as biopolymers, for ophthalmic lens manufacturing. Our interdisciplinary approach combines microalgae technology, analytical chemistry, cement production, and polymer processing to develop a sustainable circular economy model that not only addresses environmental concerns, but also offers economic benefits. This study underscores the potential of harnessing high-value products from waste streams and underscores the importance of circular economy principles in tackling pollution and resource challenges.
Comparative Life Cycle Assessment of SLS and mFFF Additive Manufacturing Techniques for the Production of a Metal Specimen
Authors: Presciutti Andrea , Gebennini Elisa , Liberti Federica , Nanni Francesca , Bragaglia Mario
Published: December 2023

This work is part of a research project aimed at developing a bio-based binder, composed mainly of polylactic acid (PLA), to produce Ti6Al4V feedstock suitable for use in MAM (Metal Additive Manufacturing) via mFFF (metal Fused Filament Fabrication), in order to manufacture a titanium alloy specimen. While in Bragaglia et al. the mechanical characteristics of this sample were analyzed, the aim used of this study is to compare the mentioned mFFF process with one of the most used MAM processes in aerospace applications, known as Selective Laser Sintering (SLS), based on the Life Cycle Assessment (LCA) method. Despite the excellent properties of the products manufactured via SLS, this 3D printing technology involves high upfront capital costs while mFFF is a cheaper process. Moreover, the mFFF process has the advantage of potentially being exported for production in microgravity or weightless environments for in-space use. Nevertheless, most scientific literature shows comparisons of the Fused Filament Fabrication (FFF) printing stage with other AM technologies, and there are no comparative LCA “Candle to Gate” studies with mFFF processes to manufacture the same metal sample. Therefore, both MAM processes are analyzed with the LCA “Candle to Gate” method, from the extraction of raw materials to the production of the finished titanium alloy sample. The main results demonstrate a higher impact (+50%) process for mFFF and higher electrical energy consumption (7.31 kWh) compared to SLS (0.32 kWh). After power consumption, the use of titanium becomes the main contributor of Global Warming Potential (GWP) and Abiotic Depletion Potential (ADP) for both processes. Finally, an alternative scenario is evaluated in which the electrical energy is exclusively generated through photovoltaics. In this case, the results show how the mFFF process develops a more sustainable outcome than SLS.
Mechanical, Electrical, and Tensile Self-Sensing Properties of Ultra-High-Performance Concrete Enhanced with Sugarcane Bagasse Ash
Authors: Lian Jinkang , Wang Yulin , Fu Tengfei , Easa Said M , Zhou Yan , Li Huawei
Published: December 2023

Although sugarcane bagasse ash (SCBA) possesses favorable cementitious properties, previous research has primarily focused on improving the mechanical performance of conventional concrete- or cement-based composites. Limited attention has been given to ultra-high-performance concrete (UHPC) with SCBA, especially regarding its tensile -sensing properties. This study aimed to comprehensively evaluate the effect of SCBA on the mechanical, electrical, and tensile self-sensing properties of UHPC. The results demonstrated that incorporating SCBA below the critical concentration of 3.0 wt% enhanced the mechanical properties of UHPC. Notably, adding 3.0 wt% SCBA remarkably improved the compressive, flexural, and tensile strengths of UHPC, resulting in increases of 13.1%, 17.4%, and 20.6%, respectively. However, excessive incorporation of SCBA adversely affected the mechanical properties due to reduced workability of UHPC, increased generation of harmful voids, and a lower degree of hydration caused by the excess SCBA. Furthermore, the inclusion of SCBA influenced the electrical resistivity of UHPC, and specifically, an SCBA content of 0.3 wt% yielded the maximum electrical resistivity. Moreover, incorporating SCBA in UHPC enhanced its tensile stress-sensing performance compared to SCBA-free UHPC. Among the various SCBA contents tested, UHPC with 0.3 wt% SCBA presented the best linearity, with values of 8.8% for loading and 17.0% for unloading, respectively, which were significantly lower than those for SCBA-free UHPC, which were 14.0% and 60.0%, respectively. Additionally, UHPC with 0.9 wt% SCBA gained the lowest hysteresis and repeatability, with values of 13.3% and 5.3%, respectively, which were much lower than those for SCBA-free UHPC, which were 50% and 51.6%, respectively. The tensile stress-sensing performance of UHPC is influenced by three key aspects: the gap between adjacent conductive fillers, contact resistance, and the connectivity of the electrical network, which are subject to change due to varying stress states and SCBA concentrations. This study should aid SCBA use and promote UHPC’s practical applications.
Composition Effect on the Formation of Oxide Phases by Thermal Decomposition of CuNiM(III) Layered Double Hydroxides with M(III) = Al, Fe
Authors: Awan Iqra Zubair , Ho Phuoc Hoang , Beltrami Giada , Fraisse Bernard , Cacciaguerra Thomas , Gaudin Pierrick , Tanchoux Nathalie , Albonetti Stefania , Martucci Annalisa , Cavani Fabrizio , Di Renzo Francesco , Tichit Didier
Published: December 2023

The thermal decomposition processes of coprecipitated Cu-Ni-Al and Cu-Ni-Fe hydroxides and the formation of the mixed oxide phases were followed by thermogravimetry and derivative thermogravimetry analysis (TG – DTG) and in situ X-ray diffraction (XRD) in a temperature range from 25 to 800 °C. The as-prepared samples exhibited layered double hydroxide (LDH) with a rhombohedral structure for the Ni-richer Al- and Fe-bearing LDHs and a monoclinic structure for the CuAl LDH. Direct precipitation of CuO was also observed for the Cu-richest Fe-bearing samples. After the collapse of the LDHs, dehydration, dehydroxylation, and decarbonation occurred with an overlapping of these events to an extent, depending on the structure and composition, being more pronounced for the Fe-bearing rhombohedral LDHs and the monoclinic LDH. The Fe-bearing amorphous phases showed higher reactivity than the Al-bearing ones toward the crystallization of the mixed oxide phases. This reactivity was improved as the amount of embedded divalent cations increased. Moreover, the influence of copper was effective at a lower content than that of nickel.
Experimental Research and Numerical Modelling of the Cold Forming Process of the Inconel 625 Alloy Sheets Using Flexible Punch
Authors: Balcerzak Maciej , Żaba Krzysztof , Hojny Marcin , Puchlerska Sandra , Kuczek Łukasz , Trzepieciński Tomasz , Novák Vit
Published: December 2023

The paper presents the numerical and experimental results of research aimed at determining the influence of hardness in the range of 50–90 Shore A of layered tools composed of elastomeric materials on the possibility of forming Inconel 625 nickel-based alloy sheets. A stamping die composed of 90MnCrV8 steel (hardness 60HRC) was designed for forming embosses in drawpieces, ensuring various stress states on the cross-section of the formed element. The principle of operating the stamping die was based on the Guerin method. The finite-element-based numerical modelling of the forming process for various configurations of polyurethane inserts was also carried out. The drawpieces obtained through sheet forming were subjected to geometry tests using optical 3D scanning. The results confirmed that, in the case of forming difficult-to-deform Inconel 625 Ni-based alloy sheets, the hardness of the polyurethane inserts significantly affected the geometric quality of the obtained drawpieces. The assumptions determined in numerical simulations were verified in experimental studies. Based on the test results, it was concluded that the selection of polyurethane hardness should be determined by the shape of the formed element. Significant nonuniform sheet metal deformations were also found, which may pose a problem in the process of designing forming tools and the technology of the plastic forming of Inconel 625 Ni-based alloy sheets.
Hydrogels in Ophthalmology: Novel Strategies for Overcoming Therapeutic Challenges
Authors: Wu Kevin Y. , Akbar Dania , Giunta Michel , Kalevar Ananda , Tran Simon D.
Published: December 2023

The human eye’s intricate anatomical and physiological design necessitates tailored approaches for managing ocular diseases. Recent advancements in ophthalmology underscore the potential of hydrogels as a versatile therapeutic tool, owing to their biocompatibility, adaptability, and customizability. This review offers an exploration of hydrogel applications in ophthalmology over the past five years. Emphasis is placed on their role in optimized drug delivery for the posterior segment and advancements in intraocular lens technology. Hydrogels demonstrate the capacity for targeted, controlled, and sustained drug release in the posterior segment of the eye, potentially minimizing invasive interventions and enhancing patient outcomes. Furthermore, in intraocular lens domains, hydrogels showcase potential in post-operative drug delivery, disease sensing, and improved biocompatibility. However, while their promise is immense, most hydrogel-based studies remain preclinical, necessitating rigorous clinical evaluations. Patient-specific factors, potential complications, and the current nascent stage of research should inform their clinical application. In essence, the incorporation of hydrogels into ocular therapeutics represents a seminal convergence of material science and medicine, heralding advancements in patient-centric care within ophthalmology.
Influence of Mg Doping on the Structure and Mechanical Properties of Al2Cu Precipitated Phase by First-Principles Calculations
Authors: Li Jiyi , Huang Yan , Zhang Xuan , Zhang Liang
Published: December 2023

Al-Cu-Mg high-strength alloys are widely used in industrial production because of their excellent mechanical performance and good machining properties. In this study, first-principles calculations based on density functional theory were carried out to investigate the influence of Mg doping on the structural stability and mechanical properties of the Al2Cu (θ) precipitated phase in Al-Cu-Mg alloys. The results show that the structural stability, electronic structure, bulk modulus, mechanical anisotropy, and thermodynamic properties of the precipitated Al2CuMgX phase change with the concentration of Mg doping (X = 2, 4, 6, and 8). The cohesive energy calculation and electronic structure analysis show that Al2CuMg6 has a high structural stability. The criterion based on elastic constants indicates that Al2CuMg2, Al2CuMg4, and Al2CuMg8 have a brittle tendency and show strong anisotropy of mechanical properties, while Al2CuMg6 shows better comprehensive mechanical properties. The thermodynamic analysis results based on the quasi-harmonic Debye model show that the Al2CuMg6 precipitated phase has good stability at high temperatures and pressure.
A Hybrid Method for Calculating the Chemical Composition of Steel with the Required Hardness after Cooling from the Austenitizing Temperature
Authors: Trzaska Jacek , Sitek Wojciech
Published: December 2023

The article presents a hybrid method for calculating the chemical composition of steel with the required hardness after cooling from the austenitizing temperature. Artificial neural networks (ANNs) and genetic algorithms (GAs) were used to develop the model. Based on 550 diagrams of continuous cooling transformation (CCT) of structural steels available in the literature, a dataset of experimental data was created. Artificial neural networks were used to develop a hardness model describing the relationship between the chemical composition of the steel, the austenitizing temperature, and the hardness of the steel after cooling. A genetic algorithm was used to identify the chemical composition of the steel with the required hardness. The value of the objective function was calculated using the neural network model. The developed method for identifying the chemical composition was implemented in a computer application. Examples of calculations of mass concentrations of steel elements with the required hardness after cooling from the austenitizing temperature are presented. The model proposed in this study can be a valuable tool to support chemical composition design by reducing the number of experiments and minimizing research costs.
Cementless Compositions for the Restoration of White Stone Based on Lime Binder and Silicon Dioxide
Authors: Repina Elizaveta , Zakrevskaya Lyubov , Panov Yuri
Published: December 2023

The condition of architectural monuments is directly influenced by various factors, such as anthropogenic, natural, and technological, leading to the degradation of both structures and construction materials, ultimately resulting in irreversible damage. These factors diminish the quality of construction materials, contributing to alterations and the destruction of the appearance and structure of white stone. The primary objective of this research is to develop cement-free compositions for restoring ancient masonry materials. Tests were conducted at the BM Department of VlSU using modern equipment. New material compositions for restoration have been devised, combining lime and silicon dioxide with chemical additives to enhance adhesive and strength properties. Adhesive strength increases by 1.5 times with the addition of white soot (silicon dioxide). Moreover, the incorporation of silicon dioxide positively impacts compressive strength (from 10.6 to 15.6 MPa), surpassing the strength of composites without white soot by 1.5 times. XRD confirms the developed composite’s similar phase composition to white stone, supported by optical microscopy and SEM results. Restoration composites based on these compositions exhibit homogeneous structures compatible with white stone and demonstrate high adhesion levels. These results make the proposed compositions promising for white stone restoration, ensuring structural and chemical compatibility with the restored surface.
Marine Bioprospecting: Enzymes and Stress Proteins from the Sea Anemones Anthopleura dowii and Lebrunia neglecta
Authors: Ramírez-Carreto Santos , Miranda-Zaragoza Beatriz , Simões Nuno , González-Muñoz Ricardo , Rodríguez-Almazán Claudia
Published: December 2023

The bioprospecting of sea anemone tissues and secretions has revealed that they are natural libraries of polypeptides with diverse biological activities that can be utilized to develop of biotechnological tools with potential medical and industrial applications. This study conducted a proteomic analysis of crude venom extracts from Anthopleura dowii Verrill, 1869, and Lebrunia neglecta Duchassaing & Michelotti, 1860. The obtained data allowed us to identify 201 polypeptides, of which 39% were present in both extracts. Among the obtained sequences, hydrolase-type enzymes, oxidoreductases, transferases, heat shock proteins, adhesion proteins, and protease inhibitors, among others, were identified. Interaction analysis and functional annotation indicated that these proteins are primarily involved in endoplasmic reticulum metabolic processes such as carbon metabolism and protein processing. In addition, several proteins related to oxidative stress were identified, including superoxide dismutase, peroxiredoxins, thioredoxin, and glutathione oxidase. Our results provide novel information on the polypeptide composition of the crude venom extract from sea anemones, which can be utilized to develop molecules for therapeutic tools and industrial applications.
Next-Generation Sequencing to Elucidate the Semen Microbiome in Male Reproductive Disorders
Authors: Davies Rhianna , Minhas Suks , Jayasena Channa N.
Published: December 2023

Mean sperm counts are declining at an accelerated rate and infertility is increasingly becoming a public health concern. It is now understood that human semen, previously considered to be sterile, harbours its own specific microbiome. Via activated leucocytes and the generation of reactive oxygen species, bacteria have the capability of evoking an immune response which may lead to sperm damage. Men with infertility have higher rates of both reactive oxygen species and sperm DNA damage. Due to the lack of sensitivity of routine culture and PCR-based methods, next-generation sequencing technology is being employed to characterise the seminal microbiome. There is a mounting body of studies that share a number of similarities but also a great range of conflicting findings. A lack of stringent decontamination procedures, small sample sizes and heterogeneity in other aspects of methodology makes it difficult to draw firm conclusions from these studies. However, various themes have emerged and evidence of highly conserved clusters of common bacteria can be seen. Depletion or over-representation of specific bacteria may be associated with aberrations in traditional and functional seminal parameters. Currently, the evidence is too limited to inform clinical practice and larger studies are needed.
Factors Associated with Newly Developed Postoperative Neurological Complications in Patients with Emergency Surgery for Acute Type A Aortic Dissection
Authors: Robu Mircea , Margarint Irina Maria , Robu Cornel , Hanganu Andreea , Radulescu Bogdan , Stiru Ovidiu , Iosifescu Andrei , Preda Silvia , Cacoveanu Mihai , Voica Cristian , Iliescu Vlad Anton , Moldovan Horațiu
Published: December 2023

Background and Objectives: Postoperative neurological complications (NCs) are an important cause of mortality in patients with acute type A aortic dissection (ATAAD). The aim of the study was to determine the association between intraoperative risk factors and newly developed postoperative NCs in patients after emergency surgery for ATAAD. Materials and Methods: A total of 203 patients requiring emergency surgery were included in the study. Patients with preoperative neurological dysfunction, deceased on the operating table or within the first 48 h after intensive care admission, with uncertain postoperative neurologic status or with incomplete records were excluded. Results: Mean age was 57.61 ± 12.27 years. Hyperlipidemia was the most frequent comorbidity (69%). A bicuspid aortic valve was present in 12.8% of cases, severe acute aortic regurgitation was present in 29.1% of patients, and cardiac tamponade was present in 27.1% of cases. The innominate artery was the most frequently dissected supra-aortic artery in 27.1% of cases. In 65% of cases, the primary entry tear was at the level of the ascending aorta. The incidence of newly developed postoperative NCs was 39.4%. The most common surgical technique performed was supra-coronary ascending aorta and hemiarch replacement, in 53.2% of patients. Using logistic regression, cardiopulmonary bypass time (OR = 1.01; 95% CI = 1.01–1.02; p < 0.001), aortic cross-clamp time over 3 h (OR = 2.71, 95% CI = 1.43–5.14, p = 0.002) and cerebral perfusion time (OR = 1.02; 95% CI = 1.002–1.03; p = 0.027) were independently associated with newly developed postoperative NCs. Conclusions: Based on the results of the study, all efforts should be made to reduce operative times. Using a simple surgical technique, like the supra-coronary ascending aorta and hemiarch technique, whenever possible, and using a simpler technique for cerebral perfusion like unilateral cerebral perfusion via the right axillary artery, could reduce operating times.
Anastomotic Leak and Perioperative Outcomes of Esophagectomy for Esophageal Cancer during the COVID-19 Pandemic: A Systematic Review and Meta-Analysis
Authors: Geropoulos Georgios , Moschonas Stavros , Fanariotis Georgios , Koltsida Aggeliki , Madouros Nikolaos , Koumadoraki Evgenia , Katsikas Triantafyllidis Kontantinos , Kechagias Konstantinos S. , Koimtzis Georgios , Giannis Dimitrios , Notopoulos Athanasios , Pavlidis Efstathios T. , Psarras Kyriakos
Published: December 2023

Background and Objectives: The coronavirus disease-2019 (COVID-19) pandemic influenced the healthcare system tremendously, as well as the number of elective surgical procedures worldwide. The aim of this study is to investigate the COVID-19 pandemic’s impact on esophagectomies. Materials and Methods: The MEDLINE (via PubMed), Cochrane Library, and Google Scholar bibliographical databases were systematically searched. Original clinical studies investigating the outcomes of esophageal cancer surgery during the COVID-19 pandemic were deemed eligible. After exclusion criteria were applied, eight studies were considered eligible for inclusion. Results: Eight studies with non-overlapping populations, reporting on patients undergoing esophagectomy for resectable esophageal cancer during the COVID-19 pandemic, were included in our analysis, with a total of 18548 patients. Background characteristics for age, lung disease, smoking history as well as Body Mass Index and age were equal among the groups. The background of diabetes presented a statistically significant difference among the groups. Perioperative outcomes like reoperation rates, the length of intensive care unit stay, or readmission rates were not significantly increased during the pandemic. The 30-day readmission, and 30- and 90-day mortality were not affected either. The length of hospital stay was significantly lower in the non-pandemic period. Conclusions: The results of our study support the evidence that in the context of the COVID-19 pandemic, esophageal cancer operations took place safely and effectively, similarly to the standards of the non-COVID-19 era.
Understanding of Depressive Symptomatology across Major Depressive Disorder and Bipolar Disorder: A Network Analysis
Authors: Lee Hyukjun , Jang Junwoo , Kang Hyo Shin , Lee Jakyung , Lee Daseul , Yu Hyeona , Ha Tae Hyon , Park Jungkyu , Myung Woojae
Published: December 2023

Background and Objectives: Depressive symptoms are prominent in both major depressive disorder (MDD) and bipolar disorder (BD). However, comparative research on the network structure of depressive symptoms in these two diagnostic groups has been limited. This study aims to compare the network structure of depressive symptoms in MDD and BD, providing a deeper understanding of the depressive symptomatology of each disorder. Materials and Methods: The Zung Self-Rating Depressive Scale, a 20-item questionnaire, was administered to assess the depressive symptoms in individuals with MDD (n = 322) and BD (n = 516). A network analysis was conducted using exploratory graph analysis (EGA), and the network structure was analyzed using regularized partial correlation models. To validate the dimensionality of the Zung SDS, principal component analysis (PCA) was adopted. Centrality measures of the depressive symptoms within each group were assessed, followed by a network comparison test between the two groups. Results: In both diagnostic groups, the network analysis revealed four distinct categories, aligning closely with the PCA results. “Depressed affect” emerged as the most central symptom in both MDD and BD. Furthermore, non-core symptoms, “Personal devaluation” in MDD and “Confusion” in BD, displayed strong centrality. The network comparison test did not reveal significant differences in the network structure between MDD and BD. Conclusions: The absence of significant differences in the network structures between MDD and BD suggests that the underlying mechanisms of depressive symptoms may be similar across these disorders. The identified central symptoms, including “Depressed affect”, in both disorders and the distinct non-core symptoms in each highlight the complexity of the depressive symptomatology. Future research should focus on validating these symptoms as therapeutic targets and incorporate various methodologies, including non-metric dimension reduction techniques or canonical analysis.
Structural and Functional Changes in Mild Cognitive Impairment in Parkinson’s Disease
Authors: Güllüoğlu Halil , Hünerli Duygu , Çakmur Raif , Çolakoğlu Berril Dönmez , Ada Emel , Yener Görsev
Published: December 2023

Background and Objectives: The pathophysiology of mild cognitive impairment in Parkinson’s disease (PD-MCI) is still not fully elucidated. It has been shown in a few studies in the literature that volume loss in the occipital, parietal and frontal cortices and atrophy in the hippocampus of PD-MCI patients can occur in the early stages of PD. The aim of this study was to evaluate the relationship between gray and white matter volumes and different neuropsychological tests and volumetric magnetic resonance imaging parameters in patients with mild cognitive impairment in Parkinson’s disease (PD-MCI). Materials and Methods: Twenty-six PD-MCI and twenty-six healthy elderly (HC) were included in this study. Results: We found that Mini Mental State Examination, Trail Making Test Part A, Clock Drawing Test, Benton Line Judgment Orientation Test and pentagon figure-copying scores were impaired in PD-MCI patients due to the decrease in brain volumes. Conclusions: Our study revealed that among PD-MCI patients, there was a more noticeable decline in White matter volume (WMV) based on volumetric Magnetic Resonance Imaging (MRI) compared to the localized loss of GMV. We think that these abnormal neuropsychological tests in PD-MCI patients can be used as pretests in the evaluation of the stage of transition to dementia.
Personalized Prophylaxis with myPKFiTCE: A Real-World Cost-Effectiveness Analysis in Haemophilia A Patients
Authors: Antonazzo Ippazio Cosimo , Cortesi Paolo Angelo , Zanon Ezio , Pasca Samantha , Morfini Massimo , Santoro Cristina , De Cristofaro Raimondo , Di Minno Giovanni , Cozzolino Paolo , Mantovani Lorenzo Giovanni
Published: December 2023

Background and Objectives: This study aimed to assess the effectiveness and costs associated with pharmacokinetics-driven (PK) prophylaxis based on the myPKFiT® device in patients affected by hemophilia A (HA) in Italy. Materials and Methods: An observational retrospective study was conducted in three Italian hemophilia centers. All patients with moderate or severe HA, aged ≥ 18 years, capable of having PK estimated using the myPKFiT device, and who had had a clinical visit between 1 November 2019 and 31 March 2022 were included. Differences in clinical, treatment, health resources, and cost data were assessed comparing post-PK prophylaxis with pre-PK. The incremental cost-effectiveness ratio (ICER) was estimated as cost (EUR) per bleed avoided. Results: The study enrolled 13 patients with HA. The mean annual bleeding rate decreased by −1.45 (−63.80%, p = 0.0055) after the use of myPKFiT®. Overall, the consumption of FVIII IU increased by 1.73% during follow-up compared to the period prior the use of the myPKFiT. Prophylaxis based on the myPKFiT resulted in an ICER of EUR 5099.89 per bleed avoided. Conclusions: The results of our study support the idea that the use of PK data in clinical practice can be associated with an improvement in the management of patients, as well as clinical outcomes, with a reasonable increase in costs.
The Clinical Impact of the Extension of Acute Type A Aortic Surgery on Long-Term Outcomes: Should We Tend to Be Conservative?
Authors: Jankovic Natasa , Matkovic Milos , Bilbija Ilija , Milicevic Vladimir , Zlatkovic Mina , Aleksic Nemanja , Cvetic Vladimir , Milin-Lazovic Jelena , Putnik Svetozar
Published: December 2023

Background and Objectives: Despite advances in surgical techniques, industry adjuncts, and cerebral perfusion techniques, the in-hospital mortality rate of type A acute dissection (TAAD) remains at 15–30%. This study aimed to investigate the influence of different extents of aortic resection on survival and quality of life (QoL) after long-term follow-up. Materials and Methods: A retrospective observational trial was performed, including 165 patients operated upon for TAAD. Patients were divided into two groups according to the extent of their aortic repair: the first group comprised patients who had ascending aorta replacement and the second included patients who had hemiarch or total arch replacement. The groups were compared with regard to their baseline characteristics, operative characteristics, survival, complications, and QoL during nine years of follow-up. Results: The mean follow-up time was 75.6 months (1–108 months). The mean survival in the ascending aorta repair group was 89.651 (81.242–98.061) months and was 54.801 (40.053–69.548) months in the hemiarch and arch group; the difference between the groups was significant (log-rank p < 0.001). The rate of new postoperative neurological deficits was statistically higher in the hemiarch and arch group (17.5% vs. 8.4%, p = 0.045), the most common being stroke, and was also more frequent in the hemiarch and arch group than in the ascending aorta group (with statistical significance (15.7% vs. 6.5%)). The mean SF-12 physical score from the QoL questionnaire was higher in the ascending aorta replacement group than in the hemiarch and arch group (50.1 ± 7.3 vs. 44.0 ± 11.9, p = 0.017). Additionally, the mean SF-12 mental score was higher in the ascending aorta replacement group (52.3 ± 7.3 vs. 47.1 ± 12.8, p = 0.032). Conclusions: A more aggressive approach involving aortic arch repair means a lower survival rate and lesser quality of life after long-term follow-up in comparison with the replacement of the ascending aorta. If clinically applicable, a more defensive strategy may be considered.
A Case of Mycoplasma Infection with an Atypical Presentation of Abducens Nerve Palsy, Erythema Multiforme and Polyarthritis without Respiratory Manifestations
Authors: Yoshimoto Kiyomi , Matsubara Masaki , Kobayashi Tadanao , Nishio Kenji
Published: December 2023

Mycoplasma pneumoniae is a self-propagating microorganism that commonly causes respiratory tract infections. It can also cause a variety of extrapulmonary symptoms with or independently of respiratory symptoms, such as skin lesions, arthralgia, myalgia, hemolysis, cardiac lesions, gastrointestinal symptoms, and central nervous system lesions, which are rare manifestations reported in approximately 0.1% of cases. In this study, we present a unique case of Mycoplasma-related abducens nerve palsy, polyarthritis, and erythema multiforme without respiratory disease. The patient was a 69-year-old woman who presented to our hospital with a skin rash, fever, arthralgia, and diplopia without respiratory symptoms. Brain magnetic resonance imaging showed optic neuritis on the right side, suggesting the diplopia was caused by right abducens nerve palsy. However, the etiologies of abducens nerve palsy were not revealed by the physical examination, blood biochemistry tests, or bacteriological examinations, including the cerebrospinal fluid examination obtained at admission. Mycoplasma infection was suspected from erythema multiforme revealed by a skin biopsy and polyarthralgia, and it was finally diagnosed according to elevated Mycoplasma particle agglutination (PA) antibodies in paired serum. Though minocycline did not improve her diplopia, the daily administration of 30 mg of prednisolone gradually improved her symptoms, and the Mycoplasma PA antibody titer, which was regularly measured in the clinical course, also decreased, suggesting a relationship between Mycoplasma infection and abducens nerve palsy. This is the first case of isolated abducens nerve palsy, which was reported as the only central neurological symptom in an adult patient with Mycoplasma infection. The mechanism or pathogenesis of CNS manifestations caused by Mycoplasma pneumoniae remains to be elucidated, and further investigation is needed. Hence, Mycoplasma infection is a common disease. Clinicians should be aware of the diverse manifestations, including abducens nerve palsy, of Mycoplasma infection and should consider Mycoplasma infection even in the absence of typical respiratory symptoms.
Analysis of Cervical Range of Motion in Subjects Affected by Temporomandibular Disorders: A Controlled Study
Authors: Nota Alessandro , Pittari Laura , Lannes Alessia Claudia , Vaghi Chiara , Calugi Benvenuti Clarissa , Tecco Simona
Published: December 2023

Background and Objectives: The aim of this study were to compare the cervical ROM data obtained from accelerometer exams between patients suffering from TMDs (study group) and healthy patients (control group). Material and Methods: A sample of 43 young adult subjects (23 control subjects and 20 TMD patients) were included in this study and analyzed with the accelerometer (Baiobit™, BTS, Garbagnate Milanese, Milan, Italy) to assess cervical ROM using a standardized protocol, including the following occlusal conditions: mandibular rest position, clenching, clenching with cotton rolls, maximal intercuspation, and mandibular position with cotton rolls. The cervical ROM was measured in degrees and expressed as the mean and standard deviation. Results: TMD patients showed a reduced cervical extension compared to control subjects in all the conditions, with statistically significant relevance. Regarding the other movements, the differences were not statistically or clinically significant. Conclusions: Based on the results of the present study, it can be observed that temporomandibular disorders are associated with a decreased cervical extension range, while the remaining components of ROM do not seem to be significantly associated. The use of accelerometers in ROM analysis could be helpful in improving interdisciplinary communication between dentists and physiotherapists.
Prevalence of Cardiovascular Comorbidities in Patients with Rheumatoid Arthritis
Authors: Rus Marius , Ardelean Adriana Ioana , Judea Pusta Claudia , Crisan Simina , Marian Paula , Pobirci Liliana Oana , Huplea Veronica , Osiceanu Alina Stanca , Osiceanu Gheorghe Adrian , Andronie-Cioara Felicia Liana , Guler Madalina Ioana
Published: December 2023

Background and Objectives: The risk of developing cardiovascular diseases (CVD) in patients suffering from rheumatoid arthritis (RA) is two times higher compared to the general population. The objective of this retrospective study was to determine which cardiovascular complications can appear in men vs. women with rheumatoid arthritis. Early diagnosis and initiation of therapeutic measures to reduce the progression rate of rheumatoid arthritis, while also maintaining an active lifestyle, are the most important problems in young patients. Materials and Methods: We included a number of 200 patients, divided into two groups according to gender (124 women and 76 men) with rheumatoid arthritis, presenting various stages of disease concomitant with cardiovascular complications. We assessed traditional and non-traditional risk factors, as well as electrocardiographic and echocardiographic findings in both groups. Results: All patients presented an atherogenic coefficient over two, indicating a significant risk of atherogenesis. Men had elevated levels of total cholesterol compared with women (≥200 mg/dL; 77.6%—men vs. 25.8%—women, p < 0.001). The participants presented cardiac arrhythmias, especially in the active stage of RA. Women had an increased risk of atrial fibrillation by 2.308 times compared to men (p = 0.020). One of the most important complications found in young women was pulmonary arterial hypertension (p = 0.007). Conclusions: In daily clinical practice, the screening of RA is carried out in sufficiently. This disease is often undiagnosed, and the risk factors remain unassessed. As a result, RA patients continue to present an increased risk of developing CVD.
Image-Based Feedback of Multi-Component Microdroplets for Ultra-Monodispersed Library Preparation
Authors: Cantwell Christy , McGrath John S. , Smith Clive A. , Whyte Graeme
Published: December 2023

Using devices with microfluidic channels can allow for precise control over liquids flowing through them. Merging flows of immiscible liquids can create emulsions with highly monodispersed microdroplets within a carrier liquid, which are ideal for miniaturised reaction vessels which can be generated with a high throughput of tens of thousands of droplets per second. Control of the size and composition of these droplets is generally performed by controlling the pumping system pushing the liquids into the device; however, this is an indirect manipulation and inadequate if absolute precision is required in the size or composition of the droplets. In this work, we extend the previous development of image-based closed-loop feedback control over microdroplet generation to allow for the control of not only the size of droplets but also the composition by merging two aqueous flows. The feedback allows direct control over the desired parameters of volume and ratio of the two components over a wide range of ratios and outperforms current techniques in terms of monodispersity in volume and composition. This technique is ideal for situations where precise control over droplets is critical, or where a library of droplets of different concentrations but the same volume is required.
Comparison of Different Cooling Schemes for AlGaN/GaN High-Electron Mobility Transistors
Authors: Song Yunqian , Chen Chuan , Wang Qidong , Feng Jianyu , Fu Rong , Zhang Xiaobin , Cao Liqiang
Published: December 2023

Cooling is important for AlGaN/GaN high-electron mobility transistors (HEMTs) performance. In this paper, the advantages and disadvantages of the cooling performance of three cooling schemes: remote cooling (R-cool), near-chip cooling (NC-cool), and chip-embedded cooling (CE-cool) are compared. The influences of distinct geometric parameters and operating conditions on thermal resistance are investigated. The results show that the thermal resistances of NC-cool and CE-cool are almost the same as each other. Decreasing microchannel base thickness (hb) significantly increases the thermal resistance of CE-cool, and when its thickness is less than a critical value, NC-cool exhibits superior cooling performance than CE-cool. The critical thickness increases when decreasing the heat source pitch (Ph) and the convective heat transfer coefficient (hconv) or increasing the thermal conductivity of the substrate (λsub). Moreover, increasing Ph or λsub significantly improves the thermal resistance of three cooling schemes. Increasing hconv significantly decreases the thermal resistances of NC-cool and CE-cool while hardly affecting the thermal resistance of R-cool. The influence of the boundary thermal resistance (TBR) on the thermal resistance significantly increases at higher λsub and larger hconv.
Magnetic-Field-Assisted Electric-Field-Induced Domain Switching of a Magnetic Single Domain in a Multiferroic/Magnetoelectric Ni Nanochevron/[Pb(Mg1/3Nb2/3)O3]0.68–[PbTiO3]0.32 (PMN–PT) Layered Structure
Authors: Cheng Chih-Cheng , Chen Yu-Jen , Lin Shin-Hung , Wang Hsin-Min , Lin Guang-Ping , Chung Tien-Kan
Published: December 2023

We report the magnetic-field-assisted electric-field-controlled domain switching of a magnetic single domain in a multiferroic/magnetoelectric Ni nanochevrons/[Pb(Mg1/3Nb2/3)O3]0.68–[PbTiO3]0.32 (PMN–PT) layered structure. Initially, a magnetic field was applied in the transverse direction across single-domain Ni nanochevrons to transform each of them into a two-domain state. Subsequently, an electric field was applied to the layered structure, exerting the converse magnetoelectric effect to transform/release the two-domain Ni nanochevrons into one of two possible single-domain states. Finally, the experimental results showed that approximately 50% of the single-domain Ni nanochevrons were switched permanently after applying our approach (i.e., the magnetization direction was permanently rotated by 180 degrees). These results mark important advancements for future nanoelectromagnetic systems.
SPH–FEM Analysis of Effect of Flow Impingement of Ultrasonic Honing Cavitation Microjet on Titanium–Tantalum Alloy Surface
Authors: Zhang Jinwei , Zhu Xijing , Li Jing
Published: December 2023

To investigate the machining effect of ultrasonic honing microjets on a titanium–tantalum alloy surface, a cavitation microjet flow impingement model was established using the smoothed particle hydrodynamics–finite element method (SPH–FEM) coupling method including the effects of wall elastic–plastic deformation, the ultrasonic field and the honing pressure field. Simulation analysis was conducted on a single impact with different initial speeds and a continuous impact at a constant initial speed. The results showed that the initial speed of the microjet needed to reach at least 580 to 610 m/s in order to obtain an obvious effect of the single impact. The single impact had almost no effect at low speeds. However, when the microjet continuously impacted the same position, obvious pits were produced via a cumulative effect. These pits were similar to that obtained by the single impact, and they had the maximum depth at the edge rather than the center. With the increase in the microjet’s initial speed, the total number of shocks required to reach the same depth gradually decreases. When the number of impacts is large, with the increase in the number of impacts, the growth rate of the maximum pit depth gradually slows down, and even shows no growth or negative growth at some times. Using the continuous impacts of the microjet by prolonging the processing time can enhance titanium–tantalum alloy machining with ultrasonic honing for material removal.
Research Progress in Fluid Energy Collection Based on Friction Nanogenerators
Authors: Yan Jin , Sheng Yuxuan , Zhang Dapeng , Tang Zhi
Published: December 2023

In recent decades, the development of electronic technology has provided opportunities for the Internet of Things, biomedicine, and energy harvesting. One of the challenges of the Internet of Things in the electrification era is energy supply. Centralized energy supply has been tested over hundreds of years of history, and its advantages such as ideal output power and stable performance are obvious, but it cannot meet the specific needs of the Internet of Things, and distributed energy supply also has a large demand. Since the invention of nanogenerators, another promising solution for fluid energy harvesting has been opened up. The triboelectric nanogenerator is an emerging platform technology for electromechanical energy conversion, which can realize the collection of fluid energy such as wind energy and wave energy. In this paper, we first introduce the fundamentals of triboelectric nanogenerators and their applications in wind and wave energy harvesting devices. We then discuss the methods of device optimization in the next development of TENG and conclude by considering the future prospects and challenges for triboelectric nanogenerator harvesting devices.
An Overview of Electrochemical Sensors Based on Transition Metal Carbides and Oxides: Synthesis and Applications
Authors: Mashhadian Amirarsalan , Jian Ruda , Tian Siyu , Wu Shiwen , Xiong Guoping
Published: December 2023

Sensors play vital roles in industry and healthcare due to the significance of controlling the presence of different substances in industrial processes, human organs, and the environment. Electrochemical sensors have gained more attention recently than conventional sensors, including optical fibers, chromatography devices, and chemiresistors, due to their better versatility, higher sensitivity and selectivity, and lower complexity. Herein, we review transition metal carbides (TMCs) and transition metal oxides (TMOs) as outstanding materials for electrochemical sensors. We navigate through the fabrication processes of TMCs and TMOs and reveal the relationships among their synthesis processes, morphological structures, and sensing performance. The state-of-the-art biological, gas, and hydrogen peroxide electrochemical sensors based on TMCs and TMOs are reviewed, and potential challenges in the field are suggested. This review can help others to understand recent advancements in electrochemical sensors based on transition metal oxides and carbides.
Evidence of a Scheduled End for Prism Growth in the Shell of Pinctada margaritifera: Closure of the Calcite Biomineralization Area by a Specific Organic Membrane
Authors: Cuif Jean-Pierre , Lo Cedrik , Dauphin Yannicke
Published: December 2023

The shell of the pearl oyster Pinctada margaritifera is made up of two layers: an outer layer of calcite prisms and an inner layer of aragonite tablets. Recent studies have shown that the calcite layer develops in a series of steps. We found that the end of prism growth and the start of aragonite deposition are also complex processes. Contrary to the common belief that prism growth is interrupted by the expansion of the aragonite layer, we found that a specific membrane covers the calcite surface before aragonite deposition starts. The earliest aragonite depositions occur as granular spots located only on the surfaces covered by this organic membrane This membrane appears to be the final stage of the calcite biomineralization cycle. This new understanding of calcite development has implications for shell biomineralization research and the production of pearls.