bluuebunny/crossref_metadata_2025 huggingface dataset:
Karbamid, pétimészsó és pétisó műtrágyák hatása a napraforgó termésmennyiségére és olajtartalmára
Authors: Szabó Béla , Csabai Judit , Kosztyuné Krajnyák Edit , Irinyiné Oláh Katalin , Szabó Miklós , Varga Csaba , Hoffmann Richárd
Published: July 2023

A hazánkban az olajipari napraforgó a harmadik legnagyobb területen termesztett szántóföldi növény. A termésátlagok folyamatos növekedése miatt egyre nagyobb jelentőséggel bír az optimális tápanyag-ellátás, azon belül is az optimális nitrogén ellátás. Vizsgálataink arra irányultak, hogy különböző nitrogénformák (karbamid, pétimészsó, pétisó), valamint azok kijuttatási időpontjai (azonos hatóanyag szintek mellett) milyen hatással vannak a növény termésmennyiségére és olajtartalmára. Kísérletünket a Nyíregyházi Egyetem Tangazdaságában, Nyírtelek Ferenc tanyán végeztük el 2020-ban, 2021-ben és 2022-ben. A fenti műtrágyaféleségeket a vizsgált években 80 kg/ha-os hatóanyagmennyiséggel juttattuk ki, egyszeri és osztott kezelést alkalmazva. A kísérleti terület nagysága 0,75 hektár volt kezelésenként, amiből 4 db 1200 m2-es parcella került kijelölésre. A betakarított termésmennyiségeket külön lemértük majd átlagoltuk. Az olajtartalom méréséhez kezelésenként egy-egy mintát vettünk. A három év eltérő eredményeket hozott. A rendkívüli aszály miatt a 2022-es év eredményei nehezen értékelhetők. A 2020-as és a 2021-es évben sem állapíthattunk meg egyértelmű tendenciákat. Az osztott kezelésekkel 2020-ban magasabb termésmennyiségeket mértünk, de a 2021-es év eredményei ezt nem támasztották alá. Olajtartalom szempontjából az osztott kezelések általában jobb eredményt produkáltak, de a különbség statisztikailag nem kimutatható.
Bükk faanyag impedancia tomográfos vizsgálata
Authors: Szakálosné Mátyás Katalin , Gubányi Gabriella
Published: July 2023

A bükk álgesztesedését vizsgáló számos külföldi és hazai szerző, sok esetben eltérően vélekedik a kiváltó és befolyásoló tényezők tekintetében, azonban az bizonyos, hogy a megváltozott klimatikus jellemzők, hidrológiai viszonyok, hőmérsékletingadozások elősegítik a faanyag minőségének, szerkezetének, összetételének átalakulását. A ’90-es évektől napjainkig sokféle próbálkozás történt a fahiba kimutatására lábon álló fák esetében. Kutatásunk célja volt – alapozva arra a tényre, hogy vezetőképességbeli különbség áll fenn az egészséges és a rendellenes farész között – az impedancia tomográf alkalmazásának gyakorlati vizsgálata és elemzése, az álgeszt detektálásának lehetőségeként. Megállapításra került, hogy amennyiben az álgesztesedés tényének a feltárását szeretnénk még élő, lábonálló faegyedek esetében meghatározni és a gesztesedés mértékét megállapítani, úgy a módszer alkalmazható.
Kérdések a hidrogén földgáz infrastruktúrába történő bekeveréséről
Authors: Vadászi Marianna , Tomkóné Nyiri Katalin
Published: July 2023

Világszerte egyre nagyobb az érdeklődés a hidrogén iránt, hiszen kiváló hő- és villamosenergia termelő alternatív energiaforrást jelenthet az ipar, a közlekedés és egyéb, alacsony szén-dioxid-kibocsátású felhasználási területeken. A hidrogénnel kapcsolatban hosszútávú célként említhető a dedikált hidrogén infrastruktúra kiépítése, azonban rövidtávú megoldásként a hidrogén földgázhálózatba történő bekeverése is ígéretesnek bizonyul. A meglévő földgázgázhálózatba történő hidrogén betáplálása azonban számos kérdést vet fel azzal kapcsolatban, hogy a jelenlegi gázinfrastruktúra képes-e hidrogénnel kevert földgázzal üzembiztosan működni. A cikk legfőbb célkitűzése annak bemutatása, hogy mennyi hidrogén integrálható a gázhálózatba, valamint azonosítani azokat a területeket, ahol további kutatásokra van szükség. A hidrogén bekeverésének technikai korlátait mind a szállító-, mind az elosztóhálózatok tekintetében érdemes megvizsgálni, mégpedig olyan kritikus működési paraméterek alapján, mint az energiasűrűség csökkenése, a megnövekedett áramlási sebesség és a nyomásveszteség. A biztonságos üzemeltetéssel kapcsolatban is felmerülnek kérdések, melyek közül a legfontosabbak a rideg töréssel, az esetleges szivárgással és a keverék gyulladásával/égésével kapcsolatban merülnek fel.
Distrofia Muscular de Duchenne/Becker
Authors: Guerra-Torres Mariana , Suárez-Obando Fernando , García-Roblesa Reggie , Ayala-Ramírez Paola
Published: July 2023

Antecedentes: las distrofias musculares son un tipo de miopatías, en su mayoría de etiología genética, caracterizadas por generar debilidad muscular progresiva. Dentro de las distrofias musculares, la Distrofia Muscular de Duchenne/Becker (DMD/B) es la más frecuente. Se produce por variaciones genéticas en el gen DMD, conduciendo a la ausencia o deficiencia de la proteína distrofina.

Tema: la distrofina es una proteína que hace parte de un complejo. En ausencia de la proteína, se generan unos mecanismos a nivel intracelular que conducen a la degeneración de la fibra muscular. Tiene un espectro clínico variable, siendo la forma menos severa y de inicio más tardío considerada como Distrofia Muscular de Becker en comparación con la Distrofia Muscular de Duchenne de inicio temprano y de mayor severidad. Sin embargo, en algunos casos no es tan fácil su clasificación de esta manera. La DMD/B no tiene un tratamiento curativo y en la actualidad los tratamientos son enfocados hacia el alivio sintomático y manejo de complicaciones. Se han desarrollado recientemente nuevas terapias que apuntan fundamentalmente a la corrección del defecto molecular en el gen DMD/B al inducir la expresión de una proteína funcional o semifuncional.

Conclusiones: la DMD/B es el tipo de distrofia muscular más frecuente y más severa, que genera gran discapacidad y con un pronóstico de vida corto. El diagnóstico temprano es fundamental para la instauración del manejo, que debe ser multidisciplinario, con el objetivo de retrasar el inicio de la pérdida de funcionalidad muscular y pérdida de la marcha.
Implementación y puesta en valor de una nueva práctica profesional en la Carrera de Nutrición y Dietética de la Universidad de Chile: Diversificando el campo laboral del Nutricionista
Authors: Caceres-Rodríguez Paola , Chavarria-Tapia Christopher , Basfi-fer-Obregón Karen , Riveros-Brieba Constanza , Bustamante-González Evelyn , Zamudio-Cañas Carolina , Daniels-Silva Bernardita , Herrera-Rojas Paulina , Molina-Carrasco Paulina
Published: July 2023

Introducción: En Chile, la situación laboral del nutricionista se ha visto afectada por la numerosa competencia y limitados cupos en las áreas laborales tradicionales. En consecuencia, la carrera de Nutrición y Dietética de la Universidad de Chile decide abrir una nueva práctica profesional en áreas de desempeño emergentes a partir del año 2021. El objetivo de este estudio fue evaluar su implementación y valoración, considerando la opinión de todos los involucrados.
Metodología: Estudio descriptivo transversal mixto con muestreo no probabilístico. Para recoger la opinión de los/as participantes se diseñaron y realizaron encuestas online a alumnos/as del último nivel y a sus supervisores, entrevistas semiestructuradas a tutores de centros de prácticas y grupos de discusión a profesores de grado. Se utilizó estadística descriptiva para los resultados cuantitativos y análisis temático para las cuestiones cualitativas.
Resultados: Se obtuvo la opinión de 27 estudiantes, 8 supervisores, 10 tutores y 13 profesores de pregrado. En cuanto a la implementación, tanto la estructura como los centros y su modalidad de práctica fueron adecuados. La valoración fue alta por parte de los implicados, destacando el desarrollo y gestión de competencias genéricas entre los/as alumnos/as, y su contribución a ampliar el campo laboral, así como el papel del nutricionista en áreas emergentes. Como aspecto a mejorar, es necesario detallar más las actividades a realizar en cada centro.
Conclusiones: La implementación de esta práctica fue exitosa, con un alto nivel de valoración. Su inclusión en el plan de estudios responde adecuadamente al perfil del egresado y a los objetivos de desarrollo de la unidad, respondiendo a necesidades previamente detectadas en el plan de estudios y en el entorno, contribuyendo así a la inserción laboral de los/as egresados/as y a la diversificación del campo actual de la disciplina.
Igniting social pedagogy through learning and teaching partnerships in a higher education context
Authors: McConnell Catherine
Published: July 2023

Partnership as an approach to pedagogic practice and co-creation in higher education is an orientation towards relationship-centred education. There is little exploration of social pedagogy in the higher education (post-secondary) context, yet recent research studied the similarities between the guiding principles underpinning learning and teaching partnerships and those of social pedagogy. This article presents the results of this empirical research, which explored the complexities of engaging ‘students as partners’ in learning and teaching in a UK university. This research found that partnership was used as an approach to democratise entrenched power relations in faculty–student relationships, empower a diverse student body to become co-creators of knowledge and foster inclusive learning communities that respect diversity and social inclusion. The three key concepts of democracy, agency and community are pillars of social pedagogy. Through this exploration of social pedagogy within the higher education context, there is significant potential for knowledge exchange between disciplines traditionally allied to social pedagogy, such as social work, K-12 education, youth work and higher education. The article develops a unique definition and conceptual framework for the case of learning and teaching partnerships, utilising social pedagogy as a guiding theoretical lens. An overview of the novel methodological approach of situational analysis is given, followed by a discussion of the key implications for higher education that: (1) learning and teaching partnerships are situated, relational and inherently complex; (2) ‘trajectories’ provide a helpful metaphor to conceptualise individuals’ unique journeys through the process of partnership; and (3) relationship-centred higher education practices involve heightened awareness of the role of emotions.
Kwestia tajemniczego autorstwa renesansowego poematu Sarca
Authors: Kowalczyk-Cantoro Daria
Published: July 2023

Dating to the 1530s, the Latin poem Sarca was published in 1842 in Rome by Angelo Mai based on a manuscript found in Vienna. Forty years after publication, the incompatibility of this edition with the Viennese manuscript was first noticed. In the second half of the last century, a polemic began challenging the theory, previously considered certain, that Sarca’s author was Pietro Bembo. Researchers named Girolamo Fracastor, Andrea Navager and Agostino Beazzan, among others, as possible authors of the text in addition to Bembo. The question of the poem’s authorship remains unresolved to this day. The aim of this article is to analyse the turbulent and hypothesis-rich debate on the attribution of the Renaissance work. The poem has been subjected to internal criticism, i.e. inferences about the author’s person based on content analysis. Historical and bibliographical indicators of the work have also been examined. The article also attempts to answer the question of whether the latest techniques used in the analysis of the linguistic and stylistic features of the text, such as the methods of computer stylometry, could prove helpful in determining the authorship of the Sarca poem.
New Polish Theatre on the Small Screen: the TV series Artyści (Artists, 2015)
Authors: Baluch Wojciech
Published: July 2023

The article describes the phenomenon of the Polish TV series Artists. Created by the theater creators Strzępka and Demirski were their TV debut. The series has become iconic among the theater community. Analyzing the series I show its sources, which are stuck in the extraordinary recent development of Polish theater dramaturgy . I also try to show how the series opens the directing to new dimensions of creativity. The changes that have taken place in the Polish theater allow to replace the dominant models of affirmation and subversion with an affective approach to art whose frame I become experience.
„… prawda musi wybrać połowę paradoksu i połowę stereotypu”. O tajemnicach Żyda wiecznego tułacza Aleksandra Wata
Authors: Tomassucci Giovanna
Published: July 2023

Aleksander Wat’s novella The Wandering Jew, published in 1926, is his only prose text in which the Jewish motif is the very center of the narrative. Wat carefully avoids dramatic or frightening notes, staying away from the characters created by Potocki, Quinet, Schubart, and Meyrink. However, certain aspects of the old version of the ancient myth remain: the millennial peregrination through history, the absolute solitude of the hero, and his magical movement and appearance in different parts of the world. The fusion of Catholicism and communism in the shadow of Marranism, represented by the protagonist Nathan, reflects grotesquely either on the phenomenon of Jewish youth fleeing the shtetls observed by young Wat, or on his own ecumenical dreams and reflections on the metahistorical role of Jews and their conversion. The article analyzes this issue also with particular regard either to the reception of the old Christian legend, or to the Anti-semitic narrative on the conspiracy of Jewish converts, shared by Keith Gilbert Chesterton, a contemporary writer very important for Wat.
Barriers to Basic School Teachers’ Implementation of Formative Assessment in the Cape Coast Metropolis of Ghana
Authors: Asare Eric , Afriyie Elizabeth
Published: July 2023

Despite the identified benefits of formative assessment to teaching and learning, its implementation in the classroom remains a significant challenge to teachers. This has widened the gap between the theory and practice of formative assessment in the classroom to enhance students’ learning. This study investigated the potential resource-related factors that affect basic teachers’ adoption of formative assessment in their classrooms. A descriptive survey design with a multistage sampling procedure was employed to select 300 teachers from the six circuits in the Cape Coast Metropolis of Ghana. Data gathered were analyzed using descriptive (mean values, SD) and inferential statistics (two-way ANOVA). Time, workload, overcrowded curriculum, class size, and the number of lessons were reported as barriers to the effective implementation of formative assessment. Findings also revealed no statistically significant interaction effect of gender and grade level on the resource-related barriers. Moreover, grade level and gender had no statistically significant main effects with respect to the resource-related barriers. Recommendations and implications for policy, practice, and future research are discussed.
Nanoscale molecular reactions in microbiological medicines in modern medical applications
Authors: Shesayar Radjarejesri , Agarwal Amit , Taqui Syed Noeman , Natarajan Yuvaraj , Rustagi Sarvesh , Bharti Sweety , Trehan Anchal , Sivasubramanian Kanagasabapathy , Muruganandham Moorthy , Velmurugan Palanivel , Arumugam Natarajan , Almansour Abdulrahman I. , Kumar Raju Suresh , Sivakumar Subpiramaniyam
Published: July 2023

Everything around us is made up of atoms and molecules. The properties of quantum atoms are sought to understand the behavior of a particular object. But with the advent of research, it was discovered that there is a quantity smaller than the molecular size. The nanoscale measures a fraction of a billionth of a meter. The atom of an object measures 0.1 nm. Since atoms are the building blocks of matter, at the nanoscale one can combine these atoms to create new materials. The proposed model displays the properties of these nano-scale elements in modern medical applications. The nano-scale research of matter is fascinating because it is the basic phase in which atoms are held together. Therefore, by manipulating material at this level, one can create many different types of objects. This proposed model calculates the operation requirements and expects the results. Based on the operational requirements, the proposed model provides the suggestions. This will be helpful for the medical researchers to identify the proper medical treatments based on the microbiological requirements.
Resilience Theory, Human Agency, and Political Archaeology: A RT Revised Model for the Understanding of the Late Bronze – Iron Age Transition in the Post-Hittite World
Authors: d’Alfonso Lorenzo
Published: July 2023

Over the last twenty years, due to the growing concern with the human-environment relationship in the contemporary world as well as in the study of the ancient world, Resilience Theory (RT) has been adopted and adapted from the study of ecosystems to the study of stress dynamics within socio-political systems. The adaptation is indebted to the seminal work of Holling and Gunderson (2002. “Resilience and Adaptive Cycles.” In Panarchy: Understanding Transformations in Human and Natural Systems, edited by L. H. Gunderson, and C. S. Holling, 25–62. Washington, DC: Island Press), reviewed recently for application in archaeology in a volume edited by Faulseit (2016b. “Collapse, Resilience, and Transformation in Complex Societies: Modeling Trends and Understanding Diversity.” In Beyond Collapse: Archaeological Perspectives on Resilience, Revitalization, and Transformation in Complex Societies, edited by R. K. Faulseit, 3–26. Visiting Scholar Conference Volumes. Carbondale, IL: Southern Illinois University Press). While social scientists, anthropologists and archaeologists interested in system theories have welcomed this new interpretative tool for the study of rapid change in socio-political systems, RT has been considered unsatisfactory and substantially rejected by several scholars in the humanities because of the lack of freedom and intention assigned to human actors. After a short presentation of these premises, the paper seeks to affirm a different model for a social cycle of formation-growth-maturity-release, in which resilience is only one among a number of possible outcomes of the release phase, depending on the collective/political choice/orientation of a society. Put simply, the new model suggests reorganization and transformation as two alternative outcomes alternative to resilience. The model is applied to the case study of the Late Bronze Age (LBA) – Early Iron Age (EIA) transition in Anatolia and north Syria, corresponding to the time of the fall and aftermath of the Hittite empire. It will be shown that the adoption of the model offers a productive interpretive key to understand different outcomes in the new fragmented reality.
Kierkegaards Begriff Angst als „gottesfürchtige Satire“
Authors: Neuber Simone
Published: July 2023

Kierkegaard՚s The Concept of Anxiety deserves to be treated as a central text on sin, but not because it introduces an ingenious intermediate psychological determination that helps to approach an explanation of the „Fall.“ Its real relevance lies in the way the text enacts the noetic effects of sin through a theoretical reflection on the possibility of sin. This essay unfolds this thesis and assigns a central hermeneutical role to Caput 4.
Is There a Suspension of Subjectivity?
Authors: Brorson Mikael
Published: July 2023

This article examines the Kierkegaard reception of the Danish theologians K. Olesen Larsen and Johannes Sløk, who both understood Kierkegaard as attempting to radically subvert the freedom of the human being. Initially, I show how current Kierkegaard research on the question of subjectivity, freedom and indirect communication differs from the readings of Olesen Larsen and Sløk. Subsequently, and in contrast to this, Olesen Larsen’s somewhat ambivalent attempt to read Kierkegaard as undermining human freedom is presented. Third, I show how Sløk arrives at a somewhat similar result, though in a more coherent way. In conclusion, the article offers a brief discussion on the plausibility of this interpretation.
“Forgiveness is forgiveness:” Kierkegaard’s Spiritual Acoustics
Authors: Esparza Daniel R.
Published: July 2023

Kierkegaard’s distinction of chatter from silence gives forgiveness a linguistic spin. How can forgiveness be spoken? Is forgiveness something to be said and heard? Is saying it aloud saying too much, or too little? What is said when (and if) forgiveness is said? Should forgiveness be chatted away, or reserved in silence? For Kierkegaard, the answer(s) is (are) neither/nor: forgiveness can only be said indirectly, kept (almost) indistinguishable from resentment or indifference, as if discarded in the face of offense—if it is to happen.
Fast vergessen: Die Nachwirkungen von Kierkegaards Kulturkritik im Krisendiskurs der dänischen Nachkriegszeit
Authors: Becker-Lindenthal Hjördis
Published: July 2023

The article examines the explicit and implicit role that Kierkegaard played in the cultural criticism developed in the literary circle of the Danish journal Heretica (1948 – 1954). The cultural criticism of Kierkegaard and eminent Danish post-war authors (Martin A. Hansen, Vilhem Grønbech, Bjørn Poulsen, Tage Skou-Hansen and Ole Wivel) is contextualized in the tradition of Western cultural criticism. An analysis of central concepts such as crisis, rationality, spirit and reflection as well as alienation, individuality and community, demonstrates the original contributions these authors make to the modern understanding of culture. Furthermore, the article addresses the reservations that some of the Heretica- authors had towards Kierkegaard. The accusation of solipsism, however, turns out to be unwarranted. Rather, it becomes clear that Kierkegaard’s emphasis on the individual, like the post-war authors’ critique of fascism, is directed against the power of the masses and the increasing bureaucratization of life. Finally, Kierkegaard as well as the 20th century authors depict neighbor love as decisive for a post-restitutive, forward-oriented way out of a severe cultural crisis.
Collagen treatment of complex anorectal fistula: 3 years follow-up
Authors: Maternini Matteo , Guttadauro Angelo , Avella Pasquale , Buondonno Antonio , Mascagni Domenico , Milito Giovanni , Stuto Angelo , Renzi Adolfo , Rennis Maria , Bottini Corrado , Quarto Gennaro , Nudo Raffaele , Del Re Luca , Amato Bruno , Gabrielli Francesco
Published: July 2023

Fistula in ano is a common anorectal disease in adults. Currently, surgery remains the definitive therapeutic approach, but in some cases, it can lead to serious complications as faecal or gas incontinence. Therefore, sphincter sparing treatments should be considered for complex fistulas. One of the sphincteric preserving treatment is the filling with a dermal extract commonly called “collagen glue” as Salvecoll-E® gel. This is a multicentric, prospective, observational study on the use of Salvecoll-E® gel in treatment of complex anal fistulas. We treated 70 patients from May 2016 to May 2017. In the first phase, we debrided the fistula tract using a loose seton kept for 4–6 weeks. In the second phase, the seton was removed and the fistula tract was filled with Salvecoll-E® gel. In this article, we report results at 36 months of follow-up. Fifty patients (71.4%) had completely healed fistula within 36 months of follow-up. Twenty-eight patients (28.2%) had recurrences. Among these failures, 65% were within 6 months. All low transphincteric fistulas healed. Recurrences occurred only in median and high transphincteric fistulas. No patient had a worsening of continence status measured with Cleveland Clinic Florida Incontinence Severity score. Salvecoll-E® gel is a recent finding among sphincter-sparing treatments. In this study, we demonstrate that it is a safe option in the treatment of complex fistulas. Final results are satisfactory and in line with the best results published in literature among mini-invasive treatments.
Realizing depth measurement and edge detection based on a single metasurface
Authors: Yang Siwen , Wei Qunshuo , Zhao Ruizhe , Li Xin , Zhang Xue , Li Yao , Li Junjie , Jing Xiaoli , Li Xiaowei , Wang Yongtian , Huang Lingling
Published: July 2023

How to simultaneously obtain the depth, edge, and other light information of the scene to accurately perceive the physical world is an important issue for imaging systems. However, such tasks usually require bulky optical components and active illumination methods. Here, we design and experimentally validate a single geometric metasurface that can achieve depth measurement or edge detection under incoherent or coherent light respectively. Double helix point source function is utilized, and three verification experiments are carried out, including double-helix beam calibration, 2D object and 3D object detection, respectively. Additionally, two-dimensional edge detection can also be achieved. This compact imaging system can enable new applications in various fields, from machine vision to microscopy.
Photocatalytic degradation of dyes in aqueous media by gum shellac stabilized selenium nanoparticles
Authors: Iqbal Zartasha , Imran Muhammad , Latif Shoomaila , Nazir Arif , Ibrahim Sobhy M. , Ahmad Iftikhar , Iqbal Munawar , Iqbal Shahid
Published: July 2023

The present work outlines the successful synthesis of selenium nanoparticles (Se NPs) stabilized with gum shellac (GS) and their use as photocatalyst for the enhanced degradation of dyes. Se NPs were synthesized by a simple and cost effective chemical reduction method using selenious acid, GS and sodium borohydride. Gum shellac was used as stabilizing agent. The orange red gum shellac-selenium nanoparticles (GS–Se NPs) were characterized by UV–Vis spectroscopy, Fourier transform infra-red (FTIR), scanning electron microscopy (SEM) and energy dispersive X-ray spectroscopy (EDX). The morphology of these particles appeared to be uniform and spherical as observed in SEM images. Energy dispersive X-ray spectroscopic profile showed the presence of elemental selenium, carbon and oxygen. The synthesized GS–Se NPs were investigated for their photo-catalytic efficiency towards degradation of methylene blue (MB) and methyl orange (MO) dye in aqueous media. Absorbance was measured at λ
max 665 nm and 455 nm for MB and MO, respectively. Maximum degradation of MB in-comparison with MO obtained at 50 mg/L were 81.72 % and 71.42 % respectively. A very slow degradation rate was observed for the MO and MB in the absence of synthesized photocatalyst whereas greater percentage degradation was observed for the GS–Se NPs.
Testosterone and quality of life in patients with dilated cardiomyopathy
Authors:   Department of Cardiology, University of Medicine and Pharmacy Craiova, Romania, Diaconu Rodica ,   Department of Physiology, University of Medicine and Pharmacy of Craiova, Romania, Neagoe Oana ,   Department of Cardiology, University of Medicine and Pharmacy Craiova, Romania, Mirea Oana ,   Department of Cardiology, University of Medicine and Pharmacy Craiova, Romania, Tieranu Eugen ,   Department of Cardiology, University of Medicine and Pharmacy Craiova, Romania, Mustafa Roxana ,   Department of Cardiology, University of Medicine and Pharmacy Craiova, Romania, Balseanu Tudor-Adrian ,   Department of Physiology, University of Medicine and Pharmacy of Craiova, Romania, Donoiu Ionut ,   Department of Cardiology, University of Medicine and Pharmacy Craiova, Romania
Published: July 2023

BACKGROUND: Testosterone is an important factor that influences the quality of life in men. The purpose of this study is to evaluate how testosterone level impacts the quality of life in patients with dilated cardiomyopathy. METHODS: This cross-sectional single-center included 97 male patients with dilated cardiomyopathy, in whom serum testosterone was measured. Health-related quality of life was measured using the translated validated version of the Kansas City Cardiomyopathy Questionnaire (KCCQ-12). We used correlation and multivariable regression to assess the association between KCCQ12 score, serum testosterone level, and clinical and paraclinical variables. RESULTS: The mean age of study participants was 58 (range 29–88). The mean LVEF was 25 ±8.61%. The average total serum testosterone level was 3.13 ±2.72 (range 0.19–13.5 ng/ml). The median global KCCQ-12 score was 44.8 (6.2–90.6) representing a poor to fair impairment in quality of life. There was an inverse correlation between the KCCQ-12 score and NYHA class (Pearson coefficient r = 0.847 p<0.001) and a direct correlation with LVEF (r=0.445, p<0.001). Also, the KCCQ-12 score correlated with hemoglobin level (r=0.214, p=0.037) and plasmatic creatinine level (r=-0.296 p= 0.004). In multivariable regression, the independent predictors of health-related quality of life were testosterone, LVEF, and NYHA class. CONCLUSIONS: The results of this study showed for the first time a significant direct relationship between serum testosterone levels and quality of life in patients with dilated cardiomyopathy.
Ceramic fragments in the Sanctuary of Artemis: permanence of the feminine cult in Archaic Thasos
Authors: Da Hora Juliana Figueira
Published: July 2023

The purpose of this article is to shed light part of the contextual methodological analysis of ceramics found in Artemísion of Thasos, an island located in the North of the Aegeus. Thasos was founded in the 7th century BC by the island of Paros, according to written sources. The sanctuary of Artemis is an important religious marker for understanding the urban expansion of the city, as well as the dynamics of female worship based on Greek Cycladic, Thracian, local and regional elements. The data collected allowed us to understand how materiality reveals issues about feminine and religious aspects based on the ceramic shards found in the sectorial contexts of Artemision of Thasos.
 
Abstract:
The aim of this article is to bring to light part of the contextual methodological analysis of the Black Figures lekane (Archaic Period) found in the Artemísion of Thassos, an island located in the North of the Aegean. The sanctuary of Artemis is an important religious marker for understanding the urban expansion of the city, as well as the dynamics of local female worship. The data collection took place from the publication of the descriptive catalog of the black figures lekane of Thassos by A. Coulié in La céramique thasiennes à figures noires of 2002 in ÉtTh XIX, the analysis of a sample of material in loco and the data collection contexts from the Bulletin Correspondance Hellenique, in which we seek to delve deeper into the analysis of archaeological contexts. This study is part of the research in the doctoral thesis, in which we analyzed a sample of 54 vases in the Museum of Thasos, a total of 126 fragments of lekane found in the sanctuary of Artemis. In this article, we will present the analysis of 2 fragments of lekane from the cutting of decorative elements of animal figures typically from Eastern Greece in the archaic period and animals with a monstrous aspect, apparently common signs in the context in question. The theoretical-methodological contribution allowed us to observe important aspects of the particularities of the female cult in Thasos, from the re-insertion of the lekane in the contextual universe and the unveiling of aspects that characterize female and religious attendance from the sectored contexts of Artemísion.
Estradiol- and Progesterone-Associated Changes in microRNA-Induced Silencing and Reduced Antiseizure Efficacy of an Antagomir in Female Mice
Authors: Tiwari Durgesh , Rajathi Valerine , Rymer Jeffrey K. , Beasley Lindsay N. , McGann Amanda M. , Bunk Alexander T. , Parkins Emma V. , Rice McKenzie F. , Smith Katie E. , Ritter David M. , White Angela R. , Doerning Carolyn M. , Gross Christina
Published: July 2023

About one-third of individuals living with epilepsy have treatment-resistant seizures. Alternative therapeutic strategies are thus urgently needed. One potential novel treatment target is miRNA-induced silencing, which is differentially regulated in epilepsy. Inhibitors (antagomirs) of specific microRNAs (miRNAs) have shown therapeutic promise in preclinical epilepsy studies; however, these studies were mainly conducted in male rodent models, and research into miRNA regulation in females and by female hormones in epilepsy is scarce. This is problematic because female sex and the menstrual cycle can affect the disease course of epilepsy and may, therefore, also alter the efficacy of potential miRNA-targeted treatments. Here, we used the proconvulsant miRNA miR-324-5p and its target, the potassium channel Kv4.2, as an example to test how miRNA-induced silencing and the efficacy of antagomirs in epilepsy are altered in female mice. We showed that Kv4.2 protein is reduced after seizures in female mice similar to male mice; however, in contrast to male mice, miRNA-induced silencing of Kv4.2 is unchanged, and miR-324-5p activity, as measured by the association with the RNA-induced silencing complex, is reduced in females after seizure. Moreover, an miR-324-5p antagomir does not consistently reduce seizure frequency or increase Kv4.2 in female mice. As a possible underlying mechanism, we found that miR-324-5p activity and the silencing of Kv4.2 in the brain were differentially correlated with plasma levels of 17β-estradiol and progesterone. Our results suggest that hormonal fluctuations in sexually mature female mice influence miRNA-induced silencing and could alter the efficacy of potential future miRNA-based treatments for epilepsy in females.
Bursting Dynamics Based on the Persistent Na+and Na+/K+Pump Currents: A Dynamic Clamp Approach
Authors: Erazo-Toscano Ricardo , Fomenko Mykhailo , Core Samuel , Calabrese Ronald L. , Cymbalyuk Gennady
Published: July 2023

Life-supporting rhythmic motor functions like heart-beating in invertebrates and breathing in vertebrates require an indefatigable generation of a robust rhythm by specialized oscillatory circuits, central pattern generators (CPGs). These CPGs should be sufficiently flexible to adjust to environmental changes and behavioral goals. Continuous self-sustained operation of bursting neurons requires intracellular Na+concentration to remain in a functional range and to have checks and balances of the Na+fluxes met on a cycle-to-cycle basis during bursting. We hypothesize that at a high excitability state, the interaction of the Na+/K+pump current, Ipump, and persistent Na+current, INaP, produces a mechanism supporting functional bursting. INaPis a low voltage-activated inward current that initiates and supports the bursting phase. This current does not inactivate and is a significant source of Na+influx. Ipumpis an outward current activated by [Na+]iand is the major source of Na+efflux. Both currents are active and counteract each other between and during bursts. We apply a combination of electrophysiology, computational modeling, and dynamic clamp to investigate the role of Ipumpand INaPin the leech heartbeat CPG interneurons (HN neurons). Applying dynamic clamp to introduce additional Ipumpand INaPinto the dynamics of living synaptically isolated HN neurons in real time, we show that their joint increase produces transition into a new bursting regime characterized by higher spike frequency and larger amplitude of the membrane potential oscillations. Further increase of Ipumpspeeds up this rhythm by shortening burst duration (BD) and interburst interval (IBI).
A Cellular Ground Truth to Develop MRI Signatures in Glioma Models by Correlative Light Sheet Microscopy and Atlas-Based Coregistration
Authors: Schregel Katharina , Heinz Lennart , Hunger Jessica , Pan Chenchen , Bode Julia , Fischer Manuel , Sturm Volker , Venkataramani Varun , Karimian-Jazi Kianush , Agardy Dennis A. , Streibel Yannik , Zerelles Roland , Wick Wolfgang , Heiland Sabine , Bunse Theresa , Tews Björn , Platten Michael , Winkler Frank , Bendszus Martin , Breckwoldt Michael O.
Published: July 2023

Glioblastoma is the most common malignant primary brain tumor with poor overall survival. Magnetic resonance imaging (MRI) is the main imaging modality for glioblastoma but has inherent shortcomings. The molecular and cellular basis of MR signals is incompletely understood. We established a ground truth-based image analysis platform to coregister MRI and light sheet microscopy (LSM) data to each other and to an anatomic reference atlas for quantification of 20 predefined anatomic subregions. Our pipeline also includes a segmentation and quantification approach for single myeloid cells in entire LSM datasets. This method was applied to three preclinical glioma models in male and female mice (GL261, U87MG, and S24), which exhibit different key features of the human glioma. Multiparametric MR data including T2-weighted sequences, diffusion tensor imaging, T2 and T2* relaxometry were acquired. Following tissue clearing, LSM focused on the analysis of tumor cell density, microvasculature, and innate immune cell infiltration. Correlated analysis revealed differences in quantitative MRI metrics between the tumor-bearing and the contralateral hemisphere. LSM identified tumor subregions that differed in their MRI characteristics, indicating tumor heterogeneity. Interestingly, MRI signatures, defined as unique combinations of different MRI parameters, differed greatly between the models. The direct correlation of MRI and LSM allows an in-depth characterization of preclinical glioma and can be used to decipher the structural, cellular, and, likely, molecular basis of tumoral MRI biomarkers. Our approach may be applied in other preclinical brain tumor or neurologic disease models, and the derived MRI signatures could ultimately inform image interpretation in a clinical setting.

SIGNIFICANCE STATEMENTWe established a histologic ground truth-based approach for MR image analyses and tested this method in three preclinical glioma models exhibiting different features of glioblastoma. Coregistration of light sheet microscopy to MRI allowed for an evaluation of quantitative MRI data in histologically distinct tumor subregions. Coregistration to a mouse brain atlas enabled a regional comparison of MRI parameters with a histologically informed interpretation of the results. Our approach is transferable to other preclinical models of brain tumors and further neurologic disorders. The method can be used to decipher the structural, cellular, and molecular basis of MRI signal characteristics. Ultimately, information derived from such analyses could strengthen the neuroradiological evaluation of glioblastoma as they enhance the interpretation of MRI data.
PENDEKATAN GEREJA DALAM MENGHADAPI KONFLIK PERKAHWINAN SESAMA JANTINA: SATU KAJIAN KEPUSTAKAAN
Authors: Muhammad Azizan bin Sabjan  , Md Yasim Mohd Azwan
Published: July 2023

The circulation of globalization in line with human change forms a family institution. Now, it is very shocking when the issue of same-sex marriage (PSJ) succeeds in threatening the sanctity of Christianity. This issue successfully pressured church institutions to take their own steps in dealing with homosexuals who want to hold PSJ. Thus, this library study aims to identify differences in church approaches in dealing with PSJ conflicts in Christianity. The results of the content analysis found that the church's approach to supporting PSJ was: love and affection between the sexes became bait for homophilic; declare acceptance of homosexual practitioners; the church is open to accepting homosexual practitioners to reduce anxiety; the church allowed PSJ at the urging of influential individuals; and the church relies on government funds to be pressured if it appoints pastors who oppose PSJ. Meanwhile, the church's approach against PSJ is: the central church forms believers following the teachings of the Bible; the church deals with homosexual practitioners by identifying the causes of homosexuality; the firmness of the church; church agreement; gain full authority to manage marriage; appointing church leaders from among men; and support heterosexual marriages. Therefore, it is suggested that the church take a long-term approach in order to continue to successfully maintain the sanctity of Christianity.
 
Peredaran arus globalisasi seiring dengan perubahan manusia membentuk institusi keluarga. Kini, amat mengejutkan apabila isu perkahwinan sesama jantina (PSJ) berjaya menggugat kesucian agama Kristian. Isu ini berjaya menekan institusi-institusi gereja untuk mengambil langkah tersendiri dalam menghadapi penganut homoseksual yang ingin melangsungkan PSJ. Justeru, kajian kepustakaan ini bertujuan untuk mengenal pasti perbezaan pendekatan gereja dalam menghadapi konflik PSJ di dalam agama Kristian. Hasil analisis kandungan mendapati pendekatan gereja menyokong PSJ adalah: cinta dan sayang sesama jantina menjadi umpan kepada homofilia; gereja bersikap terbuka menerima pengamal homoseksual untuk kurangkan kebimbangan; mengisytiharkan penerimaan pengamal homoseksual; gereja membenarkan PSJ kerana desakan individu berpengaruh; dan gereja bergantung dana kerajaan diberi tekanan jika melantik paderi yang menentang PSJ. Sementara itu, pendekatan gereja menentang PSJ pula adalah: gereja pusat membentuk penganut dahulukan Yehuwa dalam segala hal; gereja tangani pengamal homoseksual dengan mengenal pasti punca manusia melakukan seks sesama jantina; ketegasan gereja; kesepakatan gereja; mendapat kuasa penuh menguruskan perkahwinan; melantik pemimpin gereja dari kalangan lelaki; dan sokong perkahwinan heteroseksual. Justeru, dicadangkan supaya gereja mengambil pendekatan jangka masa panjang agar terus berjaya kekalkan kesucian agama Kristian.
THE USE OF WRITING FRAMEWORK AMONG INTERNATIONAL ENGLISH LANGUAGE TESTING SYSTEM LEARNERS IN PENGKALAN IPOH
Authors: JANE IRENE ANTONY
Published: July 2023

English is a medium of language that connects everyone to every part of the world. There should be a standard operating system to standardize the proficiency of people. Therefore, IELTS which is known as International English Language Testing System is being used widely for academic purposes and the general paper is catered for migration and work. However, it is apparent that students these days have low literacy in writing and do not follow a proper framework. Thus, this research is to find the impacts of the use of writing framework among IELTS learners and determine the significant factors affecting IELTS learners’ writing performance. With this a non-probability method with a mix mode of 30 participant from a single class are the sample research. The researcher uses triangulation for collection of data with three instruments which is a survey method through questionnaire, interview with three teachers who are teaching the same level and observation. The data for the questionnaire is being tabulated through statistical package of social science (SPSS) system. The finding seems to be reliable and the validity is acceptable as student seems to have a positive mindset in writing. This intervention overwrites the research gap.
THE CHALLENGES OF HIGH IMPACT RESEARCH PUBLISHING IN AFRICA: A CASE OF NIGERIA
Authors: O.Olujuwon  , B. Amao-taiwo  , G.N. Ekpe-Iko  , K. Akudo
Published: July 2023

The dissemination of research findings in reputable journals is a pride for academics as it offers global visibility on online platforms. The purpose of the research is to examine the challenges academics faced in publishing in high-impact factor journals in Nigeria and the strategies to promote high-impact factor journals. We elicit data from 151 academics from tertiary institutions in Nigeria using Google Forms an online survey comprised of structured and unstructured questionnaires, and data were analyzed using tables, simple percentages, and bar-chart. The research findings show that is impossible to determine the impact factor of all journals and that too much emphasis on impact factors could trigger unethical practices in publishing. The study further shows that high-impact journals have rigorous and thorough peer review processes which make renowned scholars publish their articles due to their high impact. Thus, the articles to be published must be original, indigenous, scientific and of relevance to human development and not just copied and pasted articles. There is a need for funding journal publications and continuous training of academics on the dynamics of publishing quality journal papers. The study concludes that putting in place competent and reputed international scholars and enforcement of the ethics of publication will enhance the standards of Nigerian journals and must be easily accessible online.
Penerapan Pendekatan Semantik Inkuisitif dalam Pengajaran dan Pembelajaran Seni Bahasa
Authors: Bujang George Romiko , Subet Mary Fatimah
Published: July 2023

Pengajaran dan pembelajaran seni bahasa dalam pendidikan Bahasa Melayu tidak dapat dipisahkan. Namun, makna implisit di sebalik bahan seni bahasa agak sukar difahami dengan mendalam terutamanya dalam kalangan murid pada peringkat pendidikan rendah. Oleh itu, kajian ini dijalankan untuk meneliti dan merungkai makna tersirat yang terkandung dalam bahan pengajaran-pembelajaran seni bahasa. Kajian berbentuk kualitatif ini menggunakan kaedah analisis teks dalam bahan seni bahasa. Kajian ini mengaplikasikan pendekatan Semantik Inkuisitif yang diperkenalkan oleh Nor Hashimah Jalaluddin (2014). Responden yang terdiri daripada 8 orang murid tahun enam dipilih untuk menyertai kajian ini. Hasil kajian mendapati penggunaan pendekatan SI dalam merungkai makna yang terkandung dalam bahan seni bahasa ini berupaya mencungkil kemahiran berfikir aras tinggi dalam kalangan murid. Pendekatan SI yang diketengahkan ini diharapkan menjadi kaedah terbaik dalam memimpin murid meneroka makna tersirat di sebalik bahan seni bahasa untuk menghasilkan impak pembelajaran yang lebih berkualiti dan bermakna selari dengan kaedah pembelajaran abad ke-21.
Teaching and learning of language arts in Malay language education is inseparable. However, the implicit meaning behind the language art material is quite challenging to understand deeply, especially among primary school pupils. Therefore, this study examined and revealed the implied intentions of the language arts material. This qualitative study uses the method of text analysis of language art materials. This study applies the Inquisitive Semantics approach introduced by Nor Hashimah Jalaluddin (2014). Eight respondents consisting of Year Six pupils were selected to participate in this study. The results showed the use of the approach in solving the meanings contained in the language art materials to develop students’ high-order thinking skills. This approach is expected to be the best method for pupils to explore the implied meaning of language arts materials in producing more quality and meaningful learning impact along with the 21st-century learning method.