bluuebunny/crossref_metadata_2025 huggingface dataset:
Last Resort Antibiotics Costs and Reimbursement Analysis of Real-Life ICU Patients with Pneumonia Caused by Multidrug-Resistant Gram-Negative Bacteria in Germany
Authors: Jeck Julia , Wingen-Heimann Sebastian M. , Jakobs Florian , Franz Jennifer , Baltin Christoph T. , Kron Anna , Böll Boris , Kochanek Matthias , Cornely Oliver A. , Kron Florian
Published: December 2022

Multidrug-resistant Gram-negative bacteria (MDR-GNB) cause serious infections and aggravate disease progression. Last resort antibiotics are effective against MDR-GNB and are reimbursed by flat rates based on German diagnosis-related groups (G-DRG). From a hospital management perspective, this analysis compared hospital reimbursement for last resort antibiotics with their acquisition costs to outline potential funding gaps. Retrospective analyses based on medical charts and real-life reimbursement data included patients with pneumonia due to MDR-GNB treated in intensive care units (ICU) of a German tertiary care hospital (University Hospital Cologne) between January 2017 and December 2020. Drug-associated hospital reimbursement of G-DRG was compared with drug acquisition costs based on preliminarily approved last resort antibiotics (cefiderocol, ceftazidime-avibactam, ceftolozane-tazobactam, and imipenem-cilastatin-relebactam) according to label. Funding gaps were determined for the treatment of Enterobacterales, Pseudomonas aeruginosa, Acinetobacter baumannii, and mixed infections, respectively. Most of the 31 patients were infected with Enterobacterales (n = 15; 48.4%) and P. aeruginosa (n = 13; 41.9%). Drug-associated G-DRG reimbursement varied from 44.50 EUR (mixed infection of P. aeruginosa and Enterobacterales) to 2265.27 EUR (P. aeruginosa; mixed infection of P. aeruginosa and Enterobacterales). Drug acquisition costs ranged from 3284.40 EUR in ceftazidime-avibactam (minimum duration) to 15,827.01 EUR for imipenem-cilastatin-relebactam (maximum duration). Underfunding was found for all MDR-GNB, reaching from 1019.13 EUR (P. aeruginosa; mixed infection of P. aeruginosa and Enterobacterales) to 14,591.24 EUR (Enterobacterales). This analysis revealed the underfunding of last resort antibiotics in German hospital treatment. Insufficient reimbursement implies less research in this field, leading to a more frequent use of inappropriate antibiotics. The cycle closes as this contributes to the development of multi-drug resistant bacteria.
Changes in Physical Activity and Health Indicators among Koreans during the COVID-19 Pandemic: Comparison between 2019 and 2020
Authors: Kim Kyungsik , Zhang Shuai , Ding Pan , Wang Yongdi , Yim Brain H. , Hu Zheming , Sui Sihong
Published: December 2022

This study aimed to compare the changes in physical activity (PA), chronic disease, and mental health indicators of Koreans before and after the COVID-19 outbreak, using raw data from more than 400,000 representative samples from the 2019–2020 Community Health Survey by the Korea Centers for Disease Control and Prevention, and to explore the correlations among them. We used two-way ANOVA to analyze changes and differences in PA and obesity levels. We assessed the influence of gender and recurrent PA using chi-square tests for mental health status and chronic disease. Finally, we performed a correlation analysis to determine the relationships among PA days, mental health, and chronic disease. The results showed that, compared to the levels before the COVID-19 period, moderate-intensity (Days: 1.415~1.217; Time: 114.688~107.321) and high-intensity (Days: 0.798~0.671; Time: 112.866~106.110) PA significantly decreased in Koreans during the COVID-19 period, while low-intensity (Time: 60.305~61.735) PA increased. Before and during the COVID-19 period, men (18,436 (8.1%)~16,124 (7.0%)) performed PA more regularly than women (13,207 (5.8%)~9382 (4.1%)). Compared to the number of regular PA participants before the COVID-19 period, regular PA participants (male, female) decreased from 31,643 (13.8%) to 25,506 (11.1%) during the COVID-19 period. Compared with the levels before the COVID-19 period, the experience rates of stress (3.1%~2.6%), depression (0.8%~0.6%), HBP (3.0%~2.2%), and diabetes (1.2%~0.9%) significantly changed under different levels of conventional PA intervention. In addition, the obesity rate during the COVID-19 period (23.957) was higher than it was before COVID-19 (23.477). During the COVID-19 period, the PA of Koreans was greatly restricted, but low-intensity PA was maintained and increased. PA is an effective activity for maintaining mental health and for preventing and reducing chronic diseases. Recommendations for appropriate intensity or a combination of high-, moderate-, and low-intensity PA should be based on the health status of Koreans to help them maintain mental health and to reduce the risk of chronic diseases during COVID-19 social distancing.
Disentangling Determinants of Ride-Hailing Services among Malaysian Drivers
Authors: Zaigham Maryum , Chin Christie Pei-Yee , Dasan Jakaria
Published: December 2022

Ride-hailing has emerged as one of the progressive sharing economy platforms. As a digital platform, both riders and drivers are critical to achieving sustainable ride-hailing transactions. Previous studies have gained little insight into ride-hailing services from drivers’ perspectives. This study investigates the salient factors that determine the usage of ride-hailing services among drivers in Malaysia by extending the technology acceptance model (TAM), introducing governmental regulations, and integrating perceived risk and trust into the model. We collected data from a total of 495 ride-hailing drivers across Malaysia. Our results suggest that a driver’s intention to use ride-hailing services is determined by perceived ease of use, perceived usefulness, and governmental regulations, which lead to actual usage. However, unexpectedly enough, the results signify that perceived risk does not affect the intention to use ride-hailing unless there is trust among the drivers. Overall, this paper draws attention to the substantial contrast in its results from the majority of prior TAM literature and has thoroughly improved the exploratory power of TAM by introducing new variables into the model, particularly from the perspective of ride-hailing drivers. This study is expected to bring theoretical and practical contributions to improve the country’s ride-hailing industry.
Comparative Studies of Perianal Structures in Myrmecophilous Aphids (Hemiptera, Aphididae)
Authors: Kaszyca-Taszakowska Natalia , Kanturski Mariusz , Depa Łukasz
Published: December 2022

There are three types of relationships between aphids and ants: non-myrmecophilous, obligatory and facultatively myrmecophilous. The degree of involvement in this mutualism is believed to be corelated with morphological adaptations of perianal structures. In this manuscript, we analyzed the differences of these structures in obligatorily (18 species) and facultatively (10 species) myrmecophilous aphids. Scanning electron microscopy (SEM) and light stereoscopic microscopy (LSM) techniques were used for these studies. Comparison of structures showed no strict relationship between their morphology and the degree myrmecophily, with certain indication that the microsculpture of perianal cuticle may play role in protection of aphids against honeydew droplet in facultatively myrmecophilous aphids.
Comparative Silk Transcriptomics Illuminates Distinctive Impact of Artificial Selection in Silkworm Modern Breeding
Authors: Zhu Kesen , Chen Yanfei , Chen Lei , Xiang Hui
Published: December 2022

Early domestication and the following improvement are two important processes in the cocoon silk evolution of silkworms. In contrast to early domestication, understanding of the improvement process is still fuzzy. By systematically comparing the larval silk gland transcriptomes of the wild, early domestic, and improved silkworms, we highlighted a novel landscape of transcriptome in the silk glands of improved ones. We first clarified that silk cocoon protein genes were up-regulated in modern breeding but not in early domestication. Furthermore, we found that differentially expressed genes (DEGs) between improved and early domestic silkworms (2711), as well as between improved and wild silkworms (2264), were obviously more than those between the early domestic and wild silkworms (158), with 1671 DEGs specific in the improved silkworm (IS-DEGs). Hierarchical clustering of all the DEGs consistently indicated that improved silkworms were significantly diverged from the early domestic and wild silkworms, suggesting that modern breeding might cause prompt and drastic dynamic changes of gene expression in the silk gland. We further paid attention to these 1671 IS-DEGs and were surprised to find that down-regulated genes were enriched in basic organonitrogen compound biosynthesis, RNA biosynthesis, and ribosome biogenesis processes, which are generally universally expressed, whereas those up-regulated genes were enriched in organonitrogen compound catabolic processes and functions involving in the dynamic regulation of protein post-translation of modification. We finally highlighted one candidate improvement gene among these up-regulated IS-DEGs, i.e., GDAP2, which may play roles in silk behavior and the overall robustness of the improved silkworm. The findings strongly suggest that modern breeding may facilitate effective control of the basic consumption of nitrogen and a stronger switch of nitrogen resources from other tissues to the silk glands, for an efficient supply for silk production, and implies the importance of brain behavior and robustness in silk yield improvement of modern breeding.
Post-Thaw Day 5 Blastocyst Culture Time Prior to Transfer Does Not Affect Assisted Reproduction Technology (ART) Outcomes in Frozen-Thawed Embryo Transfer Cycles
Authors: Ciaffaglione Marta , Reschini Marco , Balli Martina , Guarneri Cristina , Palermo Maria , Pinna Monica , Pisaturo Valerio , Somigliana Edgardo , Paffoni Alessio , Vigano’ Paola
Published: December 2022

The frozen embryo transfer (FET) technique has been progressively used more worldwide due to improved culture conditions, as well as enhanced survival rates after vitrification. However, little is known about the effect of the post-thaw blastocyst culture duration prior to transfer on live birth rate in FET cycles. In this retrospective observational study, we evaluated the influence of two distinct post-thaw blastocyst culture spans (2–4 h versus 20–22 h) on clinical pregnancy and live birth rate. A total of n = 1927 frozen–warmed cycles were included in the analysis. Among those, n = 885 warmed blastocysts were cultured for 2–4 h, and n = 1029 were kept in culture for 20–22 h prior to transfer; the remaining blastocysts did not survive the warming protocol. We observed no significant differences in live birth and clinical pregnancy rates between the two groups. The blastocyst morphological evaluation at transfer improved following the longer culture time. No differences between the two groups were found also for gestational and neonatal outcomes. This work shows that different post-thaw embryo culture timings do not negatively impact pregnancy outcomes. Overall, these results are important in the context of the embryological laboratory in order to better organize the workflow and avoid unnecessary timing-related workload.
Polysomnographic Assessment of Effects of Tobacco Smoking and Alcohol Consumption on Sleep Bruxism Intensity
Authors: Frosztega Weronika , Wieckiewicz Mieszko , Nowacki Dorian , Michalek-Zrabkowska Monika , Poreba Rafal , Wojakowska Anna , Kanclerska Justyna , Mazur Grzegorz , Martynowicz Helena
Published: December 2022

Background: Sleep bruxism (SB) is a common sleep-related movement behavior with a complex etiology. A recent hypothesis suggests psychoactive substance usage, tobacco smoking, and alcohol intake are risk factors for SB. This study aimed to evaluate SB intensity in tobacco smokers and alcohol drinkers. Methods: A total of 133 adults underwent full-night audio- and video-polysomnography, and the polysomnograms were evaluated using the American Academy of Sleep Medicine guidelines. The study group was divided into smoker and nonsmoker groups as well as drinker and non-drinker groups. Results: The results of the polysomnographic analysis confirmed that tobacco smoking has a significant effects on SB. Tobacco smokers showed increased bruxism intensity (5.50 ± 4.71 vs. 3.83 ± 3.26, p < 0.05), especially the mixed phenotype (0.93 ± 1.00 vs. 0.59 ± 0.59, p < 0.05), in the N1 sleep stage (22.84 ± 20.45 vs. 15.66 ± 13.60, p < 0.05) and the nonsupine position (4.93 ± 5.56 vs. 2.50 ± 2.31, p < 0.05). They also showed a higher number of bruxism episodes with arousal compared with nonsmokers (2.91 ± 2.83 vs. 1.61 ± 1.49, p < 0.05), indicating increased sleep fragmentation. However, no significant effect of alcohol on SB intensity was observed, and the bruxism episode index was similar in alcohol drinkers and nondrinkers. In addition, electrolyte disturbances and lipid disorders were evaluated. Compared with nonsmokers, tobacco smokers showed a higher concentration of plasma triglycerides (177.67 ± 106.9 vs. 129.18 ± 65.61) and lower levels of iron and magnesium (96.68 ± 43.58 vs. 123.83 ± 52.36 and 1.85 ± 0.22 vs. 1.96 ± 0.21, respectively). Conclusions: In summary, this study showed that tobacco smoking, but not alcohol consumption, is related to bruxism intensity and lipid and electrolyte disturbances in individuals with sleep disorders.
Answering Clinical Questions Using Machine Learning: Should We Look at Diastolic Blood Pressure When Tailoring Blood Pressure Control?
Authors: Siński Maciej , Berka Petr , Lewandowski Jacek , Sobieraj Piotr , Piechocki Kacper , Paleczny Bartłomiej , Siennicka Agnieszka
Published: December 2022

Background: The guidelines recommend intensive blood pressure control. Randomized trials have focused on the relevance of the systolic blood pressure (SBP) lowering, leaving the safety of the diastolic blood pressure (DBP) reduction unresolved. There are data available which show that low DBP should not stop clinicians from achieving SBP targets; however, registries and analyses of randomized trials present conflicting results. The purpose of the study was to apply machine learning (ML) algorithms to determine, whether DBP is an important risk factor to predict stroke, heart failure (HF), myocardial infarction (MI), and primary outcome in the SPRINT trial database. Methods: ML experiments were performed using decision tree, random forest, k-nearest neighbor, naive Bayesian, multi-layer perceptron, and logistic regression algorithms, including and excluding DBP as the risk factor in an unselected and selected (DBP < 70 mmHg) study population. Results: Including DBP as the risk factor did not change the performance of the machine learning models evaluated using accuracy, AUC, mean, and weighted F-measure, and was not required to make proper predictions of stroke, MI, HF, and primary outcome. Conclusions: Analyses of the SPRINT trial data using ML algorithms imply that DBP should not be treated as an independent risk factor when intensifying blood pressure control.
Risk Stratification of Pancreatic Neuroendocrine Neoplasms Based on Clinical, Pathological, and Molecular Characteristics
Authors: Choi Jin , Paik Woo
Published: December 2022

Pancreatic neuroendocrine neoplasms consist of heterogeneous diseases. Depending on the novel features detected by various modern technologies, their classification and related prognosis predictions continue to change and develop. The role of traditional clinicopathological prognostic factors, including classification systems, is also being refined, and several attempts have been made to predict a more accurate prognosis through novel serum biomarkers, genetic factors, and epigenetic factors that have been identified through various state-of-the-art molecular techniques with multiomics sequencing. In this review article, the latest research results including the traditional approach to prognostic factors and recent advanced strategies for risk stratification of pancreatic neuroendocrine neoplasms based on clinical, pathological, and molecular characteristics are summarized. Predicting prognosis through multi-factorial assessments seems to be more efficacious, and prognostic factors through noninvasive methods are expected to develop further advances in liquid biopsy in the future.
Relevance of Smoking Habit in Severe Asthma Patients: Evidence from the Severe Asthma Network in Italy (SANI) Registry
Authors: Caminati Marco , Guarnieri Gabriella , Paggiaro Pierluigi , Vianello Andrea , Crisafulli Ernesto , Vaia Rachele , Senna Gianenrico
Published: December 2022

Smoking habit is still fairly common among asthmatics. So far, the impact of smoke on severe asthma burden has not been specifically investigated. We aimed to estimate the frequency of smoking habit among severe asthma patients, their clinical features, and the impact of smoke on asthma outcomes. The Severe Asthma Network in Italy (SANI) registry was analyzed. Demographic, clinical, and functional features of smokers, never and former smokers were compared. Data from 1194 patients were explored. Smokers were younger, with a lower asthma onset age. Atopy, BMI and respiratory/systemic comorbidities were equally distributed. In former smokers pre- and post-FEV1/FVC was significantly lower; no other significant differences were detected. Similar findings were confirmed when stratifying the former smokers by pack-years and length of smoking cessation. Among former smokers, lymphocytes and neutrophils were higher in the <15 years of smoking cessation group. Blood eosinophils were comparable in never and former smokers. When clustering the population by blood eosinophils, no significant differences in pulmonary function and exacerbations were observed. Our data suggest that a personal smoking history has a relatively low impact on disease burden. It remarks the importance of smoking cessation as a main intervention, particularly in severe asthma.
Identifying Submarine Engineering Geologic Hazards in a Potential Gas Hydrate Target Area on the Southern Continental Margin of the South China Sea
Authors: Xu Zhenqiang , Li Yang , Yan Wei , Lv Yaoyao , Zhang Guoqing , Lu Dongyu , Zhu Zuofei
Published: December 2022

The southern continental margin-slope area of the South China Sea is a complex passive continental margin with diverse tectonic structures and movements. This area is rich in gas hydrate resources and is also an area with a high incidence of potential geological hazards. Identifying and understanding the potential submarine geological hazards in this area is very important for disaster prevention and management during the future exploration and development of marine resources. In this paper, five types of potentially hazardous geological bodies are identified in the research area through high-precision two-dimensional seismic processing and interpretation, including submarine mounds, pockmarks, mass transport deposits, submarine collapses and faults. At the same time, the seismic reflection characteristics and the changes in its morphology and surrounding strata are described. In addition to the causes of geological hazards in this region and their influence on exploration and development, the research prospects of geological hazards in this region are also suggested. Special tectonic and sedimentary conditions, fluid activities and hydrate decomposition may be the conditions for geological hazards in this region, which pose a significant threat to the exploration and development of seabed resources and marine engineering construction in this region. Not only does our conclusion provide useful data for the development and utilization of gas hydrate, but it also presents theoretical suggestions for reducing geological hazards in the development process.
A Deep Learning-Based Method to Detect Hot-Spots in the Visible Video Diagnostics of Wendelstein 7-X
Authors: Szűcs Máté , Szepesi Tamás , Biedermann Christoph , Cseh Gábor , Jakubowski Marcin , Kocsis Gábor , König Ralf , Krause Marco , Sitjes Aleix Puig ,   the W7-X Team
Published: December 2022

Wendelstein 7-X (W7-X) is currently the largest optimized stellarator in operation in the world. Its main objective is to demonstrate long pulse operation and to investigate the suitability of this type of fusion device for a power plant. Maintaining the safety of the first wall is critical to achieving the desired discharge times of approximately 30 min while keeping a steady-state condition. We present a deep learning-based solution to detect the unexpected plasma-wall and plasma-object interactions, so-called hot-spots, in the images of the Event Detection Intelligent Camera (EDICAM) system. These events can pose a serious threat to the safety of the first wall, therefore, to the operation of the device. We show that sufficiently training a neural network with relatively small amounts of data is possible using our approach of mixing the experimental dataset with new images containing so-called synthetic hot-spots generated by us. Diversifying the dataset with synthetic hot-spots increases performance and can make up for the lack of data. The best performing YOLOv5 Small model processes images in 168 ms on average during inference, making it a good candidate for real-time operation. To our knowledge, we are the first ones to be able to detect events in the visible spectrum in stellarators with high accuracy, using neural networks trained on small amounts of data while achieving near-real-time inference times.
Taxonomy and Multigene Phylogeny of Diaporthales in Guizhou Province, China
Authors: Wang Si-Yao , McKenzie Eric H. C. , Phillips Alan J. L. , Li Yan , Wang Yong
Published: December 2022

In a study of fungi isolated from plant material in Guizhou Province, China, we identified 23 strains of Diaporthales belonging to nine species. These are identified from multigene phylogenetic analyses of ITS, LSU, rpb2, tef1, and tub2 gene sequence data coupled with morphological studies. The fungi include a new genus (Pseudomastigosporella) in Foliocryphiaceae isolated from Acer palmatum and Hypericum patulum, a new species of Chrysofolia isolated from Coriaria nepalensis, and five new species of Diaporthe isolated from Juglans regia, Eucommia ulmoides, and Hypericum patulum. Gnomoniopsis rosae and Coniella quercicola are newly recorded species for China.
Fungal-Modified Lignin-Enhanced Physicochemical Properties of Collagen-Based Composite Films
Authors: Tunuhe Alitenai , Liu Pengyang , Ullah Mati , Sun Su , Xie Hua , Ma Fuying , Yu Hongbo , Zhou Yaxian , Xie Shangxian
Published: December 2022

Renewable and biodegradable materials have attracted broad attention as alternatives to existing conventional plastics, which have caused serious environmental problems. Collagen is a potential material for developing versatile film due to its biosafety, renewability, and biodegradability. However, it is still critical to overcome the low mechanical, antibacterial and antioxidant properties of the collagen film for food packaging applications. To address these limitations, we developed a new technology to prepare composite film by using collagen and fungal-modified APL (alkali pretreatment liquor). In this study, five edible and medical fungi, Cunninghamella echinulata FR3, Pleurotus ostreatus BP3, Ganoderma lucidum EN2, Schizophyllum commune DS1 and Xylariaceae sp. XY were used to modify the APL, and that showed that the modified APL significantly improved the mechanical, antibacterial and antioxidant properties of APL/Collagen composite films. Particularly, the APL modified by BP3, EN2 and XY showed preferable performance in enhancing the properties of the composite films. The tensile strength of the film was increased by 1.5-fold in the presence of the APL modified by EN2. To further understand the effect of fungal-biomodified APL on the properties of the composite films, a correlation analysis between the components of APL and the properties of composite films was conducted and indicated that the content of aromatic functional groups and lignin had a positive correlation with the enhanced mechanical and antioxidant properties of the composite films. In summary, composite films prepared from collagen and fungal biomodified APL showed elevated mechanical, antibacterial and antioxidant properties, and the herein-reported novel technology prospectively possesses great potential application in the food packaging industry.
Recognition and Management of Serotonin Toxidrome in the Emergency Department—Case Based Review
Authors: Morarasu Bianca Codrina , Coman Adorata Elena , Bologa Cristina , Lionte Catalina , Petris Ovidiu Rusalim , Ceasovschih Alexandr , Sorodoc Victorita , Haliga Raluca Ecaterina , Puha Gabriela , Stoica Alexandra , Sirbu Oana , Constantin Mihai , Sorodoc Laurentiu
Published: December 2022

Serotonin syndrome (SS) is a clinical toxidrome with high variability in clinical practice. It develops due to increased serotonin levels in the central nervous system. With an underestimated frequency, SS can develop following an overdose, a therapeutic dose increase, or drug to drug interaction of at least one serotonergic agent. It can present with autonomic signs, neuromuscular changes and an altered mental status. However, history and clinical examination are key features to formulate the diagnosis. Treatment options consist of supportive measures, discontinuation of the offending agent and certain therapeutic agents previously reported to improve outcomes. Physicians have limited experience with SS, partially due to the lack of its identification in clinical practice. Therefore, we have integrated, in a narrative review, the case of a young male with SS following an atypical antipsychotic overdose superimposed on chronic treatment with agents previously known to produce SS.
Cognitive Impairment after Post-Acute COVID-19 Infection: A Systematic Review of the Literature
Authors: Perrottelli Andrea , Sansone Noemi , Giordano Giulia Maria , Caporusso Edoardo , Giuliani Luigi , Melillo Antonio , Pezzella Pasquale , Bucci Paola , Mucci Armida , Galderisi Silvana
Published: December 2022

The present study aims to provide a critical overview of the literature on the relationships between post-acute COVID-19 infection and cognitive impairment, highlighting the limitations and confounding factors. A systematic search of articles published from 1 January 2020 to 1 July 2022 was performed in PubMed/Medline. We followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Only studies using validated instruments for the assessment of cognitive impairment were included. Out of 5515 screened records, 72 studies met the inclusion criteria. The available evidence revealed the presence of impairment in executive functions, speed of processing, attention and memory in subjects recovered from COVID-19. However, several limitations of the literature reviewed should be highlighted: most studies were performed on small samples, not stratified by severity of disease and age, used as a cross-sectional or a short-term longitudinal design and provided a limited assessment of the different cognitive domains. Few studies investigated the neurobiological correlates of cognitive deficits in individuals recovered from COVID-19. Further studies with an adequate methodological design are needed for an in-depth characterization of cognitive impairment in individuals recovered from COVID-19.
The Influence of Transparency and Disclosure on the Valuation of Banks in India: The Moderating Effect of Environmental, Social, and Governance Variables, Shareholder Activism, and Market Power
Authors: Bhimavarapu Venkata Mrudula , Rastogi Shailesh , Abraham Rebecca
Published: December 2022

Research on the impact of transparency and disclosures (TD) on the firm’s valuation presents an ambiguous result. The effect of disclosure on value is a concern because disclosure is not an economic activity. It grows further due to the embellishment of positive disclosures and the suppression of hostile facts. This situation has motivated the authors to conduct the current research. The study aims to empirically find the influence of TD on the valuation of banks in India while the Environmental, Social, and Governance Index (esgi), Shareholder activism index (shai), and Lerner Index (li) act as moderators. A panel data regression (PDR) is adopted to analyse the data in the study. Panel data for 31 public/private banks for ten years (2010–2019) are collated. The authors used econometric models to understand the linear, quadratic, and interaction association of Transparency and Disclosure (TD) with the valuation of the banks in India. It is empirically found that TD alone does not impact the valuation of banks but is positively associated with a bank’s value under the influence of the moderators, Environmental, Social, and Governance variables (esgi), and shareholder activism (shai).
Crime under the Light? Examining the Effects of Nighttime Lighting on Crime in China
Authors: Peng Chong , Sun Weizeng , Zhang Xi
Published: December 2022

With Chinese people’s increasing willingness to participate in night activities, local governments have begun regarding the nighttime economy as an important means to stimulate urban vitality and increase social employment. This study uses changes in urban nighttime light brightness as a measure of environmental factors to examine the social effects of nighttime activities. Based on panel data for 227 prefecture-level cities in China from 2000 to 2013, this study empirically investigates the effect and mechanism of nighttime light brightness on the urban crime rate. Empirical results show that (1) a 1% increase in nighttime light brightness increases criminal arrest rate and prosecution rate by 1.474% and 2.371%, respectively; (2) the effects are larger in developed areas with higher levels of lighting and economic development, or in urban areas (compared with rural areas), and (3) the mechanism test shows that such effects are more pronounced in cities with more nighttime business, confirming the existence of a crime opportunity effect.
Resistance to Some New Drugs and Prevalence of ESBL- and MBL-Producing Enterobacteriaceae Uropathogens Isolated from Diabetic Patients
Authors: Alzahrani Othman M. , Uddin Fakhur , Mahmoud Samy F. , Alswat Amal S. , Sohail Muhammad , Youssef Mona
Published: December 2022

Diabetes is a leading non-communicable disease and a risk factor for relapsing infections. The current study was aimed at investigating the prevalence and antibiotic susceptibility of carbapenem-resistant (CR) uropathogens of the family Enterobacteriaceae in diabetic patients. The data of 910 bacterial isolates was collected from diagnostic laboratories during January 2018 to December 2018. The bacterial isolates were identified using traditional methods including colonial characteristics, biochemical tests, and API (20E). Antimicrobial susceptibility and phenotypic characterization of ESBL, MBLs, and KPC was determined by utilizing CLSI recommended methods. The phenotypically positive isolates were further analyzed for resistance-encoding genes by manual PCR and Check-MDR CT103XL microarray. Susceptibility to colistin and cefiderocol was tested in accordance with CLSI guidelines. The data revealed that most of the patients were suffering from type 2 diabetes for a duration of more than a year and with uncontrolled blood sugar levels. Escherichia coli and Klebsiella pneumoniae were the most frequently encountered pathogens, followed by Enterobacter cloacae and Proteus mirabilis. More than 50% of the isolates showed resistance to 22 antibiotics, with the highest resistance (>80%) against tetracycline, ampicillin, and cefazolin. The uropathogens showed less resistance to non-β-lactam antibiotics, including amikacin, fosfomycin, and nitrofurantoin. In the phenotypic assays, 495 (54.3%) isolates were found to be ESBL producers, while ESBL-TEM and -PER were the most prevalent ESBL types. The resistance to carbapenems was slightly less (250; 27.5%) than ESBL producers, yet more common amongst E. coli isolates. MBL production was a common feature in carbapenem-resistant isolates (71.2%); genotypic characterization also validated this trend. The isolates were found to be sensitive against the new drugs, cefiderocol and eravacycline. with 7–28% resistance, except for P. mirabilis which had 100% resistance against eravacycline. This study concludes that a few types of ESBL and carbapenemases are common in the uropathogens isolated from the diabetic patients, and antibiotic stewardship programs need to be revisited, particularly to cure UTIs in diabetic patients.
In Vivo Pathogenicity of Methicillin-Susceptible Staphylococcus aureus Strains Carrying Panton–Valentine Leukocidin Gene
Authors: Yildirim Funda , Sudagidan Mert , Aydin Ali , Akyazi Ibrahim , Bayrakal Gulay Merve , Yavuz Orhan , Gurel Aydin
Published: December 2022

Toxin-producing Staphylococcus aureus strains posing a potential risk for public health have long been a topic of scientific research. Effects of Panton–Valentine leukocidin (PVL) on tissue destruction mechanisms and activities of inflammatory cells were presented in animal models of pneumonia and skin infections induced by PVL-producing S. aureus strains. This study aimed to demonstrate the in vivo pathogenicity of PVL-producing S. aureus strains isolated from some foodstuffs, which can be a potential risk to public health. PVL-positive methicillin-susceptible S. aureus (MSSA) strains M1 and YF1B-b isolated from different foodstuffs and a PVL-positive MSSA strain HT480 (positive control) were administered to New Zealand rabbits. Blood samples were harvested three and six hours after the intratracheal inoculation. Lung tissue samples were collected for gross and microscopic exams and immunohistochemical (IHC) demonstration of IL-6, IL8, IL-10, and TNF-α expressions. Serum cytokine levels were also measured by ELISA. The strains isolated from lung tissue samples were confirmed by pulsed-field gel electrophoresis. The development of acute necrotising pneumonia and a significant elevation in IL-6, IL-8, IL-10, and TNF-α expressions demonstrated the significance of foodborne PVL-positive MSSA strains in public health for the first time.
Gear Wheel Finishing with Abrasive Brushing Tools to Improve the Surface Quality of Tooth Flanks for the Industrial Application
Authors: Gülzow Bernhard , Uhlmann Eckart
Published: December 2022

A high surface quality of tooth flanks can improve the service life and the performance of gears, as well as reduce acoustic emissions. However, high demands on the gear geometry pose a challenge for the finishing of tooth flank surfaces because the dimensional accuracy that can be achieved with modern grinding processes must not be impaired by the finishing process. A preceding study has shown fundamentally that profiled abrasive brushing tools can be used to improve the quality of individual tooth flank surfaces. Due to the integration into the grinding machine, it represents a promising alternative to common finishing applications. Before the process can be used in an industrial environment, process reliability and tool life must be examined. For this purpose, complete reference gearwheels (39 × 10) were finished with the brushing tools. It could be shown that the surface roughness can be reliably reduced by ΔRa ≈ 0.2 µm by using a single brush for an entire gearwheel without changing the gear geometry. In addition to the influence of the tool specifications on the work result, the influence of the initial roughness after grinding was considered in particular. It was found that the achievable surface roughness depends significantly on the depth of the grinding grooves, as these are retained as desired, while the roughness peaks are fully smoothed. Furthermore, a device for the machine-integrated profiling and dressing of brushing tools was successfully designed, implemented, and tested.
New Anti-Derailment System in Railway Crossings
Authors: Sala Antonio J. , Felez Jesus , de Dios Sanz Juan , Gonzalez Jaime
Published: December 2022

The objective of this paper is to design a new system to reduce the risk of derailment at crossings, which are critical points in railway lines. Crossings are a common element in conventional lines of current railway systems and are the only point on the track where there is a discontinuity. Our proposal is based on adding an element to the crossing that occupies part of the crossing gap, providing a larger support surface next to the wing rail, such that the wheel does not fall into the gap. The lateral force—which is the most influential parameter in derailments—is substantially decreased, thus reducing the risk of derailment due to lifting on the rail. The proposed approach also increases the safety of the dynamic behaviour, which has a direct impact on passenger comfort and influences the service life of both the rolling stock and the track, thus reducing the cost and even increasing safety at higher speeds. It has a simple structure that is easy to assemble and does not interrupt traffic during installation. The results of simulations using this innovative solution indicate a significant reduction in lateral stresses and strains on the track, which undoubtedly produces an improvement in traffic safety; however, the results cannot be fully quantified in terms of accident reduction with only the data obtained from simulations. Therefore, it was concluded that implementation of the new crossing design provides better conditions for rolling stock to run on turnouts, increasing safety by reducing the risk of derailment. Nevertheless, it will be necessary to carry out a program of experimental tests, which we intend to make the subject of future research.
Quantitative Criteria for the Degree of Pathological Remodeling of the Aortic Duct
Authors: Talygin Eugene , Gorodkov Alexander , Tibua Teona , Bockeria Leo
Published: December 2022

Analysis of the properties of the aorta was carried out by numerous researchers using several parameters. However, the general laws of change in the dynamic geometry of the aortic flow channel in connection with the hydrodynamics of the swirling blood flow have not been studied properly. Therefore, at present, attempts to correct various diseases are carried out based on the location of the aneurysm, and not in accordance with the general patterns of changes in the dynamic geometry of the entire aortic channel. For a proper understanding of the aortic flow channel remodeling mechanisms, it is necessary to determine the quantitative parameters that formalize the geometry of this channel. The geometric shape of the aorta primarily depends on the hydrodynamics of the flow inside the aortic flow channel, which is the only source of force impact on its walls. The main result of the present study was that we obtained the new quantitative parameters that characterize the normal aorta and the degree of its shape deviations caused by pathological changes of the aortic duct. These parameters were calculated based on the software processing of the three-dimensional aortic reconstruction in normal conditions and in the case of differently localized aortic aneurysm.
Computational Modeling of Latent Heat Thermal Energy Storage in a Shell-Tube Unit: Using Neural Networks and Anisotropic Metal Foam
Authors: Shafi Jana , Ghalambaz Mehdi , Fteiti Mehdi , Ismael Muneer , Ghalambaz Mohammad
Published: December 2022

Latent heat storage in a shell-tube is a promising method to store excessive solar heat for later use. The shell-tube unit is filled with a phase change material PCM combined with a high porosity anisotropic copper metal foam (FM) of high thermal conductivity. The PCM-MF composite was modeled as an anisotropic porous medium. Then, a two-heat equation mathematical model, a local thermal non-equilibrium approach LTNE, was adopted to consider the effects of the difference between the thermal conductivities of the PCM and the copper foam. The Darcy–Brinkman–Forchheimer formulation was employed to model the natural convection circulations in the molten PCM region. The thermal conductivity and the permeability of the porous medium were a function of an anisotropic angle. The finite element method was employed to integrate the governing equations. A neural network model was successfully applied to learn the transient physical behavior of the storage unit. The neural network was trained using 4998 sample data. Then, the trained neural network was utilized to map the relationship between control parameters and melting behavior to optimize the storage design. The impact of the anisotropic angle and the inlet pressure of heat transfer fluid (HTF) was addressed on the thermal energy storage of the storage unit. Moreover, an artificial neural network was successfully utilized to learn the transient behavior of the thermal storage unit for various combinations of control parameters and map the storage behavior. The results showed that the anisotropy angle significantly affects the energy storage time. The melting volume fraction MVF was maximum for a zero anisotropic angle where the local thermal conductivity was maximum perpendicular to the heated tube. An optimum storage rate could be obtained for an anisotropic angle smaller than 45°. Compared to a uniform MF, utilizing an optimum anisotropic angle could reduce the melting time by about 7% without impacting the unit’s thermal energy storage capacity or adding weight.
Swarm-Inspired Computing to Solve Binary Optimization Problems: A Backward Q-Learning Binarization Scheme Selector
Authors: Becerra-Rozas Marcelo , Lemus-Romani José , Cisternas-Caneo Felipe , Crawford Broderick , Soto Ricardo , García José
Published: December 2022

In recent years, continuous metaheuristics have been a trend in solving binary-based combinatorial problems due to their good results. However, to use this type of metaheuristics, it is necessary to adapt them to work in binary environments, and in general, this adaptation is not trivial. The method proposed in this work evaluates the use of reinforcement learning techniques in the binarization process. Specifically, the backward Q-learning technique is explored to choose binarization schemes intelligently. This allows any continuous metaheuristic to be adapted to binary environments. The illustrated results are competitive, thus providing a novel option to address different complex problems in the industry.
Explosivity and Time-Varying Granger Causality: Evidence from the Bubble Contagion Effect of COVID-19-Induced Uncertainty on Manufacturing Job Postings in the United States
Authors: Bekun Festus Victor , Alhassan Abdulkareem , Ozturk Ilhan , Gimba Obadiah Jonathan
Published: December 2022

This study evaluates the explosive behavior and Granger causality episodes in manufacturing job postings in the United States (JOBPUS) and COVID-19-induced uncertainty (COVIDEMV). This study applied the novel unit root tests with explosive behavior, and the novel time-varying Granger causality test for a sample period ranging from 1 January 2020 to 29 July 2022. Further, this study used date stamping to identify the subperiods of the explosive behavior and causality. The findings revealed that JOBPUS exhibits explosive behavior, with several episodes of exuberance (bubbles) across the sample period while COVIDEMV does not exhibit explosivity during the period. However, the results of the causality provide evidence of bidirectional causality, with several episodes between the variables. Moreover, the episodes of the explosivity and causality coincide with significant episodes in the history of the COVID-19 pandemic worldwide and in the United States particularly, such as the date when United States recorded a COVID-19-related death toll of over 100,000 people for the first time, after the presidential election, after Halloween celebrations, after the discovery and administration of COVID-19 vaccines as well as the discovery of the Delta and the Omicron variants of COVID-19. Therefore, the time-series characteristics of JOBPUS and its causal nexus with COVIDEMV largely depend on the intensity of the instability caused by the pandemics. Hence, explosivity and time-varying causal behavior should necessarily be accounted for when modelling the job market conditions in the United States, particularly during pandemic-related crises.
Case Report of Dermoscopic Aspects and Reflectance Confocal Microscopy Description of Segmental Leiomyoma and Relative Management
Authors: Paolino Giovanni , Pampena Riccardo , Rizzo Nathalie , Di Nicola Matteo Riccardo , Mercuri Santo Raffaele
Published: December 2022

Cutaneous leiomyoma is a benign tumor, mainly composed of smooth muscle cells and arising from the arrector pili muscle of hair follicles. The diagnosis of leiomyomas is of paramount importance, as they can often be associated with underlying malignancies (e.g., renal cell carcinoma, leiomyosarcoma) and specific genetic mutations. We report the case of a 27-year-old Caucasian male patient that presented to our attention with a rare segmental and Zoosteriform type II leiomyoma. We performed an analysis of the cutaneous lesions using dermoscopy, reflectance confocal microscopy (RCM) and histology. We found that, using dermoscopy, the leiomyomas showed a dermatofibroma-like appearance with a central hypopigmented area, peripheral delicate hyperpigmentation and also erythematous areas and ectatic vessels. RCM, although not specific, showed groups of hypo-reflective areas distributed in the most superficial papillary dermis, which in histology and immunohistochemistry corresponded to the most superficial protrusions in the papillary dermis of the tumoral bundles. Finally, we discuss the management of patients with multiple leiomyomas and stress the fact that, in the cases of multiple leiomyomas, an annual sonography of the kidneys associated with dermatological and (in women) gynecological consultations are needed to ensure the early identification of an underlying tumor. A genetic consultation to detect an eventual FH mutation is recommended, but since in some cases the FH result may be negative, the above recommended controls remain always of paramount importance.
Development and Validation of a Difficulty Scoring System for Laparoscopic Liver Resection to Treat Hepatolithiasis
Authors: Jo Yeongsoo , Cho Jai Young , Han Ho-Seong , Yoon Yoo-Seok , Lee Hae Won , Lee Jun Suh , Lee Boram , Lee Eunhye , Park Yeshong , Kang MeeYoung , Lee Junghyun
Published: December 2022

Background and Objectives: A difficulty scoring system was previously developed to assess the difficulty of laparoscopic liver resection (LLR) for liver tumors; however, we need another system for hepatolithiasis. Therefore, we developed a novel difficulty scoring system (nDSS) and validated its use for predicting postoperative outcomes. Materials and Methods: This was a retrospective study. We used clinical data of 123 patients who underwent LLR for hepatolithiasis between 2003 and 2021. We analyzed the data to determine which indices were associated with operation time or estimated blood loss (EBL) to measure the surgical difficulty. We validated the nDSS in terms of its ability to predict postoperative outcomes, namely red blood cell (RBC) transfusion, postoperative hospital stay (POHS), and major complications defined as grade ≥IIIa according to the Clavien–Dindo classification (CDC). Results: The nDSS included five significant indices (range: 5–17; median: 8). The RBC transfusion rate (p < 0.001), POHS (p = 0.002), and major complication rate (p = 0.002) increased with increasing nDSS score. We compared the two groups of patients divided by the median nDSS (low: 5–7; high: 8–17). The operation time (210.7 vs. 240.7 min; p < 0.001), EBL (281.9 vs. 702.6 mL; p < 0.001), RBC transfusion rate (5.3% vs. 37.9%; p < 0.001), POHS (8.0 vs. 13.3 days; p = 0.001), and major complication rate (8.8% vs. 25.8%; p = 0.014) were greater in the high group. Conclusions: The nDSS can predict the surgical difficulty and outcomes of LLR for hepatolithiasis and may help select candidates for the procedure and surgical approach.