bluuebunny/crossref_metadata_2025 huggingface dataset:
Impacts of Energy Structure on Carbon Emissions in China, 1997–2019
Authors: Ge Fengjian , Li Jiangfeng , Zhang Yi , Ye Shipeng , Han Peng
Published: May 2022

To mitigate climate change, reducing carbon dioxide (CO2) emissions is of paramount importance. China, the largest global CO2 emitter, proposes to peak carbon emissions by 2030 and become carbon neutral by 2060; transforming the energy structure represents one of the primary means of addressing carbon emissions; thus, it is essential to investigate the impacts of alternate energy sources throughout the country. Based on energy consumption and carbon emissions data from 30 provincial-level administrative regions in China (excluding Tibet, Hong Kong, Taiwan, and Macau, due to the lack of data), the study here investigated the shares of coal, petroleum, natural gas, and non-fossil energy sources (i.e., hydropower, nuclear power, wind power, solar power, and biomass power), as they relate to total, per capita, and per unit GDP CO2 emissions via spatial regression. The results showed that: (1) The epicenters of coal and carbon emissions have shifted from the east to the central and western regions; (2) There is a significant correlation between energy structure and carbon emissions: coal has a positive effect, petroleum’s effects are positive at first, and negative subsequently; while both natural gas and non-fossil energy sources have a negative impact; (3) Provincial-level carbon emissions are affected by energy structure, carbon emissions in neighboring regions, and other factors.
Influence of the In-Stream Structure on Solute Transport in the Hyporheic Zone
Authors: Li Han , Liu Ying , Feng Jinghong , Liu Defu , Li Yi , Chen Lihui , Xiao Jingwen
Published: May 2022

The hyporheic zone (HZ) plays an important role in the river ecosystem, and hyporheic exchange and solute transport in the HZ are important ecological functions. However, the relationship between the design parameters of river structure and solute transport is still poorly understood. In this study, we combined flume experiments and numerical simulations to systematically evaluate how in-stream structures impact the solute transport depth (DP), hyporheic vertical exchange flux (Q), and solute flux (Qs). The results showed that the in-stream structure had a significant influence on solute transport in the HZ and could obviously increase the intensity of hyporheic exchange and promote solute transport. Model results indicated that DP, Q, and Qs increased with the ratio of ground height to underground height of structure (H/D) and structure number (N), while Q, DP, and Qs increased with the structural spacing (S) to begin with; then, Q remained constant, and DP and Qs decreased as S continued to increase. This study deepened our understanding of the influence of in-stream structural design parameters on HZ solute transport, which is helpful to provide a theoretical basis for ecological restoration projects in the river HZ.
Job Satisfaction Level of Safety and Health Manager in Construction Industry: Pandemic Period
Authors: Choi Won , Lee Sang-joon , Lee Woo-je , Beak Eun-mi , Kim Ki-youn
Published: May 2022

In a widespread social turmoil such as the Pandemic, job groups with high turnover rates and high job stress, such as the construction industry, will have a greater adverse impact than the general job group. This is to be used as basic data in preparing management plans by identifying the factors that hinder job stress and job satisfaction of construction workers. In this study, during the Pandemic period (1 September 2021 to 31 December 2021), a survey was conducted on job stress and job satisfaction among safety and health managers working at construction sites. The overall job satisfaction of workers in the construction industry was grasped by analyzing the level of correlation and the mutual influence on job stress, job satisfaction, general characteristics, and work-related characteristics. As a result, in terms of work characteristics, it was found that the smaller the working period in the current position, the more positive the job satisfaction was (p < 0.01). In addition, it was found that job satisfaction increased significantly when there was a promotion opportunity (p < 0.001). The construction industry is a job group with high basic job stress and low job satisfaction. In addition, it was evaluated that job stress increased during the pandemic.
Purpose in Life in Older Adults: A Systematic Review on Conceptualization, Measures, and Determinants
Authors: AshaRani PV , Lai Damien , Koh JingXuan , Subramaniam Mythily
Published: May 2022

Purpose in life (PIL) is a psychological construct that reflects one’s life goals and the desire or determination to pursue them. Having a purpose provides an intrinsic motivation to adopt healthy behaviors as we age, which will help us to achieve positive health outcomes. Thus, promoting PIL is the cornerstone for successful aging and better health outcomes. This systematic review aims to identify how PIL is conceptualized, measured in the existing literature and what are the determinants of PIL in older adults (≥65 years). Electronic searches were conducted in five databases (Medline, PsychInfo, Embase, CINAHL and Web of Science). A total of 44 studies were included in the review. PIL was conceptualized in six different ways: health and well-being, meaningful goals and purpose, inner strength, social relationships, mattering to others, and spirituality and religiousness. There were six main questionnaires and semi structured interviews used to capture PIL. Female gender, higher education and income, being married, ethnicity, health and well-being, inner strength, social integration and spirituality were associated with PIL. Majority of the included studies had low to moderate Risk of Bias (RoB) assuring confidence in the results. The conceptual frameworks of PIL identified in the review underscore the complexity of the construct. Several sociodemographic and other determinants of PIL were identified.
Geometric Mean Serum Cotinine Concentrations Confirm a Continued Decline in Secondhand Smoke Exposure among U.S. Nonsmokers—NHANES 2003 to 2018
Authors: Caron Kevin T. , Zhu Wanzhe , Bernert John T. , Wang Lanqing , Blount Benjamin C. , Dortch Kristin , Hunter Ronald E. , Harmon Tia , Akins J. Ricky , Tsai James , Homa David M. , Pirkle James L. , Sosnoff Connie S.
Published: May 2022

The objective of this study was to examine long-term trends in serum cotinine (COT) concentrations, as a measure of secondhand smoke (SHS) exposure, in U.S. nonsmokers using data from the National Health and Nutrition Examination Surveys (NHANES) from 2003 to 2018. We analyzed NHANES serum COT results from 8 continuous NHANES 2 year cycles from 2003 to 2018 using a liquid chromatography–tandem mass spectrometry assay that has been maintained continuously at the Centers for Disease Control and Prevention (CDC) since 1992. Serum COT concentrations (based on the geometric means) among nonsmokers in the U.S. decreased by an average of 11.0% (95% confidence interval (CI) [8.8%, 13.1%]; p < 0.0001) every 2 year cycle. From 2003 to 2018, serum COT concentrations in U.S. nonsmokers declined by 55.0%, from 0.065 ng/mL in 2003–2004 to 0.029 ng/mL in 2017–2018 (p < 0.0001). Significant decreases in serum COT concentrations were observed in all demographic groups. While disparities between these groups seems to be shrinking over time, several previously observed disparities in SHS exposure remain in 2017–2018. Serum COT concentrations of the non-Hispanic Black population remained higher than those of non-Hispanic Whites and Mexican Americans (p < 0.0001). Additionally, serum COT concentrations were significantly higher for children aged 3–5 years than other age groups (p ≤ 0.0002), and men continued to have significantly higher serum COT concentrations than women (p = 0.0384). While there is no safe level of exposure to SHS, the decrease in serum COT concentrations in the U.S. population as well as across demographic groupings represents a positive public health outcome and supports the importance of comprehensive smoke-free laws and policies for workplaces, public places, homes, and vehicles to protect nonsmokers from SHS exposure.
Non-Standard Employment and Unemployment during the COVID-19 Crisis: Economic and Health Findings from a Six-Country Survey Study
Authors: Gunn Virginia , Vives Alejandra , Zaupa Alessandro , Hernando-Rodriguez Julio C. , Julià Mireia , Kvart Signild , Lewchuk Wayne , Padrosa Eva , Vos Mattias Philippe , Ahonen Emily Q. , Baron Sherry , Bosmans Kim , Davis Letitia , Díaz Ignacio , Matilla-Santander Nuria , Muntaner Carles , O’Campo Patricia , Östergren Per-Olof , Vanroelen Christophe , Vignola Emilia F. , Bodin Theo
Published: May 2022

The COVID-19 crisis is a global event that has created and amplified social inequalities, including an already existing and steadily increasing problem of employment and income insecurity and erosion of workplace rights, affecting workers globally. The aim of this exploratory study was to review employment-related determinants of health and health protection during the pandemic, or more specifically, to examine several links between non-standard employment, unemployment, economic, health, and safety outcomes during the COVID-19 pandemic in Sweden, Belgium, Spain, Canada, the United States, and Chile, based on an online survey conducted from November 2020 to June 2021. The study focused on both non-standard workers and unemployed workers and examined worker outcomes in the context of current type and duration of employment arrangements, as well as employment transitions triggered by the COVID-19 crisis. The results suggest that COVID-19-related changes in non-standard worker employment arrangements, or unemployment, are related to changes in work hours, income, and benefits, as well as the self-reported prevalence of suffering from severe to extreme anxiety or depression. The results also suggest a link between worker type, duration of employment arrangements, or unemployment, and the ability to cover regular expenses during the pandemic. Additionally, the findings indicate that the type and duration of employment arrangements are related to the provision of personal protective equipment or other COVID-19 protection measures. This study provides additional evidence that workers in non-standard employment and the unemployed have experienced numerous and complex adverse effects of the pandemic and require additional protection through tailored pandemic responses and recovery strategies.
Deducing Flood Development Process Using Social Media: An Event-Based and Multi-Level Modeling Approach
Authors: Liu Yang , Li Rui , Wang Shunli , Wu Huayi , Gui Zhipeng
Published: May 2022

Social media is increasingly being used to obtain timely flood information to assist flood disaster management and situational awareness. However, since data in social media are massive, redundant, and unstructured, it is tricky to intuitively and clearly obtain effective information. To automatically obtain clear flood information and deduce flood development processes from social media, the authors of this paper propose an event-based and multi-level modeling approach including a data model and two methods. Through the hierarchical division of events (division into spatial object, phase, and attribute status), the flood information structure (including time, space, topic, emotion, and disaster condition) is defined. We built an entity construction method and a development process deduction method to achieve the automatic transition from cluttered data to orderly flood development processes. Taking the flooding event of the Yangtze and Huai Rivers in 2020 as an example, we successfully obtained true flood information and development process from social media data, which verified the effectiveness of the model and methods. Meanwhile, spatiotemporal pattern mining was carried out by using entities from different levels. The results showed that the flood was from west to east and the damage level was positively correlated with the number of flood-related social media texts, especially emotional texts. In summary, through the model and methods in this paper, clear flood information and dynamic development processes can be quickly and automatically obtained, and the spatiotemporal patterns of flood entities can be examined. It is beneficial to extract timely flood information and public sentiments towards flood events in order to perform better disaster relief and post-disaster management.
Pressure Loading Induces DNA Damage in Human Hepatocyte Line L02 Cells via the ERK1/2–Dicer Signaling Pathway
Authors: Tang Yanping , Fan Yanan , Luo Qing , Song Guanbin
Published: May 2022

Alteration of liver tissue mechanical microenvironment is proven to be a key factor for causing hepatocyte injury and even triggering the occurrence of hepatocellular carcinoma; however, the underlying mechanisms involved are not fully understood. In this study, using a customized, pressure-loading device, we assess the effect of pressure loading on DNA damage in human hepatocytes. We show that pressure loading leads to DNA damage and S-phase arresting in the cell cycle, and activates the DNA damage response in hepatocytes. Meanwhile, pressure loading upregulates Dicer expression, and its silencing exacerbates pressure-induced DNA damage. Moreover, pressure loading also activates ERK1/2 signaling molecules. Blockage of ERK1/2 signaling inhibits pressure-upregulated Dicer expression and exacerbates DNA damage by suppressing DNA damage response in hepatocytes. Our findings demonstrate that compressive stress loading induces hepatocyte DNA damage through the ERK1/2–Dicer signaling pathway, which provides evidence for a better understanding of the link between the altered mechanical environment and liver diseases.
Repercussions of Bisphenol A on the Physiology of Human Osteoblasts
Authors: García-Recio Enrique , Costela-Ruiz Víctor J. , Melguizo-Rodriguez Lucía , Ramos-Torrecillas Javier , García-Martínez Olga , Ruiz Concepción , de Luna-Bertos Elvira
Published: May 2022

(1) Background: Bisphenol A (BPA) is an endocrine disruptor that is widely present in the environment and exerts adverse effects on various body tissues. The objective of this study was to determine its repercussions on bone tissue by examining its impact on selected functional parameters of human osteoblasts. (2) Methods: Three human osteoblast lines were treated with BPA at doses of 10−5, 10−6, or 10−7 M. At 24 h post-treatment, a dose-dependent inhibition of cell growth, alkaline phosphatase activity, and mineralization was observed. (4) Results: The expression of CD54 and CD80 antigens was increased at doses of 10−5 and 10−6 M, while the phagocytic capacity and the expression of osteogenic genes (ALP, COL-1, OSC, RUNX2, OSX, BMP-2, and BMP-7) were significantly and dose-dependently reduced in the presence of BPA. (5) Conclusions: According to these findings, BPA exerts adverse effects on osteoblasts by altering their differentiation/maturation and their proliferative and functional capacity, potentially affecting bone health. Given the widespread exposure to this contaminant, further human studies are warranted to determine the long-term risk to bone health posed by BPA.
Short-Chain Fatty Acids in Chronic Kidney Disease: Focus on Inflammation and Oxidative Stress Regulation
Authors: Magliocca Giorgia , Mone Pasquale , Di Iorio Biagio Raffaele , Heidland August , Marzocco Stefania
Published: May 2022

Chronic Kidney Disease (CKD) is a debilitating disease associated with several secondary complications that increase comorbidity and mortality. In patients with CKD, there is a significant qualitative and quantitative alteration in the gut microbiota, which, consequently, also leads to reduced production of beneficial bacterial metabolites, such as short-chain fatty acids. Evidence supports the beneficial effects of short-chain fatty acids in modulating inflammation and oxidative stress, which are implicated in CKD pathogenesis and progression. Therefore, this review will provide an overview of the current knowledge, based on pre-clinical and clinical evidence, on the effect of SCFAs on CKD-associated inflammation and oxidative stress.
Identification and Characterization of Circular RNAs in Brassica rapa in Response to Plasmodiophora brassicae
Authors: Liu Huishan , Nwafor Chinedu Charles , Piao Yinglan , Li Xiaonan , Zhan Zongxiang , Piao Zhongyun
Published: May 2022

Plasmodiophora brassicae is a soil-borne pathogen that attacks the roots of cruciferous plants and causes clubroot disease. CircRNAs are noncoding RNAs, widely existing in plant and animal species. Although knowledge of circRNAs has been updated continuously and rapidly, information about circRNAs in the regulation of clubroot disease resistance is extremely limited in Brassica rapa. Here, Chinese cabbage (BJN 222) containing clubroot resistance genes (CRa) against P. brassicae Pb4 was susceptible to PbE. To investigate the mechanism of cicRNAs responsible for clubroot disease resistance in B. rapa, circRNA-seq was performed with roots of ‘BJN 222’ at 0, 8, and 23 days post-inoculated (dpi) with Pb4 and PbE. A total of 231 differentially expressed circRNAs were identified between the groups. Based on the differentially expressed circRNAs, the circRNA–miRNA–mRNA network was constructed using the target genes directly or indirectly related to plant resistance. Upregulated novel_circ_000495 suppressed the expression of miR5656-y, leading to the upregulation of Bra026508, which might cause plant resistance. Our results provide new insights into clubroot resistance mechanisms and lay a foundation for further studies exploring complex gene regulation networks in B. rapa.
Dichotomous Roles of Men1 in Macrophages and Fibroblasts in Bleomycin—Induced Pulmonary Fibrosis
Authors: Lu Yuanhua , Zhao Jianan , Tian Yafei , Shao Dan , Zhang Zhiqi , Li Siqi , Li Jialin , Zhang Hugang , Wang Wei , Jiao Ping , Ma Jie
Published: May 2022

Pulmonary fibrosis therapy is limited by the unclear mechanism of its pathogenesis. C57BL/6 mice were used to construct the pulmonary fibrosis model in this study. The results showed that Men1, which encodes menin protein, was significantly downregulated in bleomycin (BLM)—induced pulmonary fibrosis. Mice were made to overexpress or had Men1 knockdown with adeno-associated virus (AAV) infection and then induced with pulmonary fibrosis. BLM—induced pulmonary fibrosis was attenuated by Men1 overexpression and exacerbated by Men1 knockdown. Further analysis revealed the distinct roles of Men1 in fibroblasts and macrophages. Men1 inhibited fibroblast activation and extracellular matrix (ECM) protein expression while promoting macrophages to be profibrotic (M2) phenotype and enhancing their migration. Accordingly, pyroptosis was potentiated by Men1 in mouse peritoneal macrophages (PMCs) and lung tissues upon BLM stimulation. Furthermore, the expression of profibrotic factor OPN was positively regulated by menin in Raw264.7 cells and lung tissues by binding to the OPN promoter region. Taken together, although Men1 showed antifibrotic properties in BLM—induced pulmonary fibrosis mice, conflictive roles of Men1 were displayed in fibroblasts and macrophages. The profibrotic role of Men1 in macrophages may occur via the regulation of macrophage pyroptosis and OPN expression. This study extends the current pathogenic understanding of pulmonary fibrosis.
Expression and Role of Vitellogenin Genes in Ovarian Development of Zeugodacus cucurbitae
Authors: Chen Dong , Han Hong-Liang , Li Wei-Jun , Wang Jin-Jun , Wei Dong
Published: May 2022

Vitellogenin (Vg) genes encode the major egg yolk protein precursor in arthropods. In this study, four Vgs were identified in Zeugodacus cucurbitae (Coquillett). Sequence analysis showed that four ZcVgs had the conserved Vg domain. Phylogenetic analysis indicated that four ZcVgs were homologous to the Vgs of Tephritidae insects. The temporal and spatial expression patterns of ZcVgs were analyzed by quantitative real-time polymerase chain reaction (RT-qPCR), and the four ZcVgs showed high expression levels in female adults, especially in the fat body. The expression of ZcVg1 and ZcVg3 was down-regulated by a low dosage (0.5 μg) of 20-hydroxyecdysone (20E), and ZcVg2, ZcVg3, and ZcVg4 were up-regulated by a high dosage (1.0 and 2.0 μg) of 20E. The expression of ZcVg1 and ZcVg2 was up-regulated by 5 μg of juvenile hormone (JH), while all of the ZcVgs were down-regulated by a low and high dosage of JH. Expression of ZcVgs was down-regulated after 24 h of starvation and recovered to normal after nutritional supplementation. After micro-injection of the gene-specific double-stranded RNA, the ZcVgs’ expression was significantly suppressed, and ovarian development was delayed in Z. cucurbitae females. The results indicate that RNA interference of reproduction-related genes is a potential pest control method that works by manipulating female fertility.
Transversal Arch Clamping for Complete Resection of Aneurysms of the Distal Ascending Aorta without Open Anastomosis
Authors: Rukosujew Andreas , Motekallemi Arash , Wisniewski Konrad , Weber Raluca , De Torres-Alba Fernando , Ibrahim Abdulhakim , Weiss Raphael , Martens Sven , Dell’Aquila Angelo Maria
Published: May 2022

Background: The extent of aortic replacement for aneurysms of the distal ascending aorta remains controversial and opinions vary between standard cross-clamp resection and open hemiarch anastomosis in circulatory arrest and selective cerebral perfusion. As the deleterious effects of extended circulatory arrest are well-known, borderline indication for distal ascending aorta aneurysm repair must be outweighed against the potential risk of complications related to the open anastomosis. In the present study, we describe our own approach consisting of “transversal arch clamping” for exhaustive resection of aneurysms of the distal ascending aorta without open anastomosis and we present the postoperative outcomes. Methods: Between May 2017 and December 2019, 35 patients with aneurysm of the ascending aorta (20 male, 15 female) underwent replacement with repair of the lesser curvature without circulatory arrest. Pre-operative, intraoperative, and postoperative clinical outcomes were retrospectively withdrawn from our institutional database and analyzed. Results: Maximal diameter of distal ascending aorta was 47.5 mm. Patient median age was 66 years (IQR 14) (range 42–86). Preoperative logistic median EuroSCORE II was 17% (IQR 11.3). Median duration of cardiopulmonary bypass and cardiac arrest were 137 (IQR 64) and 93 (IQR 59) min, respectively. In-hospital and 30-day mortality were 0%. There were no cases with acute low output syndrome, surgical re-exploration for bleeding, kidney injury requiring dialysis, or wound infection. Disabling stroke was observed in one patient (2.9%). There was one case of major ventricular arrhythmia (2.9%). Conclusions: Our institutional experience suggests that this novel technique is safe and feasible. It facilitates complete resection of the aortic ascending aneurysm avoiding circulatory arrest, antegrade cerebral perfusion, additional peripheral cannulation, and all related complications.
Clinicians’ Perspectives on Barriers and Facilitators for the Adoption of Non-Invasive Liver Tests for NAFLD: A Mixed-Method Study
Authors: Vali Yasaman , Eijk Roel , Hicks Timothy , Jones William S. , Suklan Jana , Holleboom Adriaan G. , Ratziu Vlad , Langendam Miranda W. , Anstee Quentin M. , Bossuyt Patrick M. M.
Published: May 2022

(1) Background: Given the high prevalence of non-alcoholic fatty liver disease (NAFLD) and the limitations of liver biopsies, multiple non-invasive tests (NITs) have been developed to identify non-alcoholic fatty liver disease (NAFLD) patients at-risk of progression. The availability of these new NITs varies from country to country, and little is known about their implementation and adoption in routine clinical practice. This study aims to explore barriers and facilitators that influence the adoption of NAFLD NITs, from healthcare professionals’ perspectives. (2) Methods: A cross-sectional study was performed using an exploratory mixed-methods approach. Twenty-seven clinicians from eight different countries with different specialties filled in our questionnaire. Of those, 16 participated in semi-structured interviews. Qualitative and quantitative data were collected and summarized using the recently published Non-adoption, Abandonment, Scale-up, Spread, and Sustainability (NASSS) framework for new medical technologies in healthcare organizations. (3) Results: Several factors were reported as influencing the uptake of NITs for NAFLD in clinical practice. Among those: insufficient awareness of tests; lack of practical guidelines and evidence for the performance of tests in appropriate patient populations and care settings; and absence of sufficient reimbursement systems were reported as the most important barriers. Other factors, most notably ‘local champions’, proper functional payment systems, and sufficient resources in academic hospitals, were indicated as important facilitating factors. (4) Conclusions: Clinicians see the adoption of NITs for NAFLD as a complex process that is modulated by several factors, such as robust evidence, practical guidelines, a proper payment system, and local champions. Future research could explore perspectives from other stakeholders on the adoption of NITs.
Lung Aeration in COVID-19 Pneumonia by Ultrasonography and Computed Tomography
Authors: Kalkanis Alexandros , Schepers Christophe , Louvaris Zafeiris , Godinas Laurent , Wauters Els , Testelmans Dries , Lorent Natalie , Van Mol Pierre , Wauters Joost , De Wever Walter , Dooms Christophe
Published: May 2022

We conducted a prospective single-center observational study to determine lung ultrasound reliability in assessing global lung aeration in 38 hospitalized patients with non-critical COVID-19. On admission, fixed chest CT scans using visual (CTv) and software-based (CTs) analyses along with lung ultrasound imaging protocols and scoring systems were applied. The primary endpoint was the correlation between global chest CTs score and global lung ultrasound score. The secondary endpoint was the association between radiographic features and clinical disease classification or laboratory indices of inflammation. Bland–Altman analysis between chest CT scores obtained visually (CTv) or using software (CTs) indicated that only 1 of the 38 paired measures was outside the 95% limits of agreement (−4 to +4 score). Global lung ultrasound score was highly and positively correlated with global software-based CTs score (r = 0.74, CI = 0.55–0.86; p < 0.0001). Significantly higher median CTs score (p = 0.01) and lung ultrasound score (p = 0.02) were found in severe compared to moderate COVID-19. Furthermore, we identified significantly lower (p < 0.05) lung ultrasound and CTs scores in those patients with a more severe clinical condition manifested by SpO2 < 92% and C-reactive protein > 58 mg/L. We concluded that lung ultrasound is a reliable bedside clinical tool to assess global lung aeration in hospitalized non-critical care patients with COVID-19 pneumonia.
Acquired Haemophilia A: A 15-Year Single-Centre Experience of Demography, Clinical Features and Outcome
Authors: Guerrero Camacho Raisa , Álvarez Román María Teresa , Butta Coll Nora , Zagrean Damaris , Rivas Pollmar Isabel , Martín Salces Mónica , Gasior Kabat Mercedes , Jiménez-Yuste Víctor
Published: May 2022

Acquired haemophilia A (AHA) is a rare severe bleeding disorder resulting from the production of autoantibodies directed against coagulation factor VIII. At presentation, bleeding events can be severe, and an early diagnosis and treatment are of major importance. The current study aims to analyse the treated patients who have been diagnosed with AHA for a better understanding of our population and treatment outcome. We conducted a retrospective study with 26 patients who had been diagnosed with AHA and who were treated in our hospital between January 2006 and January 2021. The patients ranged in age from 30 to 85 years old: 46.10% were men, 46.10% had no known underlying condition, 27% had an underlying malignancy, 7.60% presented with other diseases: psoriatic arthritis and Paget’s disease, and 19.30% presented with AHA during puerperium. All of the patients had bleeding events and were treated with bypass agents for this as well as with immunosuppressive therapy to eradicate the inhibitor. A total of 53.80% of the patients had major bleeding. Sixty-nine percent of the patients achieved complete remission, but 26.90% died during the follow-up, although bleeding was not the cause of death in any of these cases. Our observations underline the importance of clinical suspicion and early referral to centres with experience and laboratory facilities for managing AHA.
Cytotoxicity of Methacrylate Dental Resins to Human Gingival Fibroblasts
Authors: Sulek Jolanta , Luczaj-Cepowicz Elzbieta , Marczuk-Kolada Grazyna , Rosłan Maciej , Holownia Adam
Published: May 2022

This study aimed to assess the acute and delayed cytotoxicity of three, popular light-cured methacrylate-based restorative resins (MRs): Charisma (C), Estelite (E), and Filtek (F), to human gingival fibroblasts in culture. Cells were grown for up to 24 h with light-cured (or pre-cured) resins. We evaluated resin cytotoxicity, redox imbalance, necrosis/apoptosis, miR-9, and heat shock protein 70 (HSP70). The role of resin-induced oxidative stress (damage) in HSP70-response (repair) was assessed using binary fluorescence labeling. All MRs decreased viable cell numbers and cell proliferation and damaged cell membranes, and their 24 h-delayed toxicity was lower (C), higher (F), or similar (E) to that induced by freshly-cured resins. Cell membrane damage induced by C and E decreased with time, while F produced a linear increase. All resins generated intracellular oxidative stress with the predominant necrotic outcome, and produced heterogeneous responses in miR-9 and HSP70. The double fluorescence (damage/repair) experiments pointed to common features of E and F but not C. In the subset of cells, the binary response induced by E and F was different from C, similar to each other, and positively interrelated. Experimental data show that selective MR cytotoxicity should be taken into account when considering repetitive use or massive reconstruction.
Global Gridded Argo Dataset Based on Gradient-Dependent Optimal Interpolation
Authors: Zhang Chunling , Wang Danyang , Liu Zenghong , Lu Shaolei , Sun Chaohui , Wei Yongliang , Zhang Mingxing
Published: May 2022

The international Argo Program was launched at the turn of the millennium. It has since collected over 2 million vertical profiles of temperature and salinity from the upper 2000 m of the global ocean. Gridded interpolation is a technology that gives full play to the advantages of these profiles because they are scattered. This study develops a global gridded Argo dataset, called GDCSM-Argo, by using an improved gradient-dependent correlation scale method. The dataset is theoretically verified, its error-related statistics are recorded, and it is compared with other datasets to establish its reliability. The results show that the maximum mean RMSEs are 0.8 °C for temperature and 0.1 for salinity, and more than 90% of the analysis results are reliable under the statistical probability of 95%. Not only can GDCSM-Argo adequately preserve large-scale signals in the ocean but also retain more mesoscale features than other gridded Argo datasets. Preliminary applications also verify that GDCSM-Argo can systematically describe the spatio-temporal features of multiple elements in the global ocean, and is a useful tool in many areas of research.
Impact of Third-Generation Cephalosporin Resistance on Recurrence in Children with Febrile Urinary Tract Infections
Authors: Kim Sin Young , Jang Min Sik , Kim Jihye
Published: May 2022

Background: The purpose of this study was to investigate the association between third-generation cephalosporin resistance and urinary tract infection (UTI) recurrence in patients who underwent voiding cystourethrogram (VCUG). Methods: In this retrospective study, data were obtained from hospitalized pediatric patients who had a first febrile UTI episode and subsequently underwent VCUG. Information based on VCUG was mandatory to identify the presence of vesicoureteral reflux (VUR). A multivariable logistic model was used to identify the risk factors for recurrence. Recurrence was divided into early (90-day) and late (1-year), and sensitivity analyses were performed according to each definition. The estimates of all the statistical models were internally validated using bootstrap samples. Results: A total of 210 patients were included, and the overall recurrence rate of UTI was 26.2% (55 of 210). Third-generation cephalosporin resistance was a significant risk factor for early recurrence (odds ratio: 2.79 [1.08–7.20]) but not for late recurrence. Sensitivity analyses showed that third-generation cephalosporin resistance was a significant risk factor for 60-day recurrence but not for 180-day recurrence. A VUR grade ≥ 3 was identified as a consistent risk factor for both early and late recurrence. Conclusions: Third-generation cephalosporin resistance was a significant risk factor for the early recurrence of pediatric UTI in patients who underwent VCUG.
Multi-Dimensional Urbanization Coordinated Evolution Process and Ecological Risk Response in the Yangtze River Delta
Authors: Li Xin , Fang Bin , Yin Mengru , Jin Tao , Xu Xin
Published: May 2022

The dislocated development of population, land, and economy will disturb the urban system, cause ecological risk problems, and ultimately affect regional habitat and quality development. Based on social statistics and nighttime lighting data from 2000 to 2018, we used mathematical statistics and spatial analysis methods to analyze the change process of urbanization’s coupling coordination degree and ecological risk response pattern in the Yangtze River Delta. Results show that: ① From 2000 to 2018, the coupling coordination degree of urbanization in the Yangtze River Delta increased, with high values in Suzhou-Wuxi-Changzhou, Shanghai, Nanjing and Hangzhou regions. ② The ecological risk in the Yangtze River Delta weakened, and the vulnerability and disturbance of landscape components together constitute the spatial differentiation pattern of regional ecological risk, which presented homogeneous aggregation and heterogeneous isolation. ③ The overall ecological stress of urbanization in the Yangtze River Delta decreased. ④ The population aggregation degree, socio-economic development level and built-up area expansion trend contributed to the spatiotemporal differentiation of urbanization’s ecological risks through the synergistic effects of factor concentration and diffusion, population quality cultivation and improvement, technological progress and dispersion, industrial structure adjustment and upgrading. This study can provide a reference for regional urbanization to deal with ecological risks reasonably and achieve high-quality development.
To Preserve Green Buffer under Polarization and Diffusion Effects of a Fast-Developing Megalopolis
Authors: Li Xiaohong , Zhang Jiuhong , Huang Jinxia , Lin Wenhao , Wu Shengjun , Ma Maohua
Published: May 2022

The polarization and diffusion effects of landscape patterns are important features of megalopolis development. Under the urbanized effects, green space is a key spatial unit in delivering vital ecosystem services for sustainable urban planning. However, currently, fast urban developing is swamping the green space. In this study, by tracing landscape pattern changes of a fast-developing megalopolis, the Chengdu-Chongqing Megalopolis in the southeast of China, and using land-use data from 1980 to 2020, we aimed to determine the polarization and diffusion effects of the megalopolis and their impacts on the green space within and between the cities. We found that: (1) during the past four decades, spatial expansion of the megalopolis mainly occupied grassland and farmland, triggering an increase in landscape fragmentation; (2) based on socio-economic indicators, the spatial-attraction network analysis showed a significant polarization effect; however, based on the natural landscape, this analysis demonstrated a more scattered pattern; (3) importantly, the megalopolis developed at quite a similar pace, which caused the green rural area between the central cities demonstrating an encroached trend by the urbanization. To promote sustainability of the fast-developing megalopolis, we suggest that the boundary of the green space should be broadened to form a green network in which natural green space and urban green space are interconnected, improving the connectivity of habitats within the megalopolis for urban biodiversity. Our study implied that maintaining the green buffer shall be considered in advance for sustainable megaregional planning and establishing resilience of the fast-developing megalopolis.
X-ray Structure Determination of Naphthalen-2-yl 1-(Benzamido(diethoxyphosphoryl)methyl)-1H-1,2,3-triazole-4-carboxylate
Authors: Fall Serigne Abdou Khadir , Hajib Sara , Aouine Younas , Ouarsal Rachid , Alami Anouar , El Omari Mohamed , Assani Abderrazzak , Saadi Mohamed , El Ammari Lahcen
Published: May 2022

We have previously published on a new triazolic phosphonic α-amino ester in position 4 on the triazole ring of a naphthalene ester. The aim of the present paper was to describe its crystallographic study by XRD. The crystal structure of naphthalen-2-yl 1-(benzamido(diethoxyphosphoryl)methyl)-1H-1,2,3-triazole-4-carboxylate was determined by single-crystal X-ray diffraction. This compound crystallizes in the monoclinic system, space group P21/c. The naphthalene system is almost planar and makes dihedral angles of 67.1(2)° and 63.9(2)° with the triazole ring and the phenyl cycle, respectively. The phosphorus atom is surrounded by three oxygen atoms and one carbon atom building a distorted tetrahedron. It is also noted, that one of the two ethyl groups is disordered. In the crystal, the molecules are connected through C-H…O and N-H…O hydrogen bonds to build dimers that are linked together by C-H…O hydrogen bonds, in addition to C-H…π interactions. The presence of an intramolecular hydrogen bond contributes to the stability of the molecular conformation by completing the S(5) cycle.
Investigation on Strain Hardening and Failure in Notched Tension Specimens of Cold Rolled Ti6Al4V Titanium Alloy
Authors: Zhang Hao , Gao Tao , Chen Jian , Li Xunpeng , Song Haipeng , Huang Ganyun
Published: May 2022

Uniaxial and notched tension samples are utilized to investigate the damage and failure of titanium alloy Ti6Al4V. The strain fields on the samples are obtained by the digital image correlation (DIC) method. Strain localization occurs before fracturing in all samples, and the width and size of the localized zone are characterized. Slant fractures are observed in uniaxial and notched tension specimen, which indicate that the initiation and propagation of cracks in thin sheet specimens are highly affected by the shear stress. Numerical simulations were performed for identification of hybrid hardening laws, and the results were compared with the experiments. The influence of the stress triaxiality on damage mechanism of Ti6Al4V was analyzed by observation of the specimen fracture surfaces using SEM. The results show that a higher stress triaxiality facilitates the formation and growth of micro-voids, which leads to a decrement of strain at failure.
New Functional Organic Materials and Their Photoelectric Applications: A New Open Special Issue of Materials
Authors: Yin Ruonan , Lv Jing-Jing
Published: May 2022

New Functional Organic Materials and Their Photoelectric Applications is a new open Special Issue of Materials, which focuses on designing and fabricating advanced functional organic optoelectronic materials and makes great contributions to investigating their properties, related applications, and underlying mechanisms [...]
Functional Safety Analysis and Design of Sensors in Robot Joint Drive System
Authors: Chen Lingyu , Fan Dapeng , Zheng Jieji , Xie Xin
Published: May 2022

The reliable operation of the sensors of robot joint drive systems (RJDs) is a key factor in ensuring the safety of equipment and personnel. Over the years, additional safety-related systems have been designed to prevent safety incidents caused by robot failures, ignoring the functional safety issues of the robot sensors themselves. In view of this, based on IEC61508, a functional safety analysis and design method for sensors of RJDs is proposed in this paper. Firstly, the hazard analysis and risk assessment clarified the goals that the safety protection function of the RJD’s sensor should achieve. Then, by establishing the motor drive model and transmission model, a model-based sensor fault diagnosis and isolation strategy is proposed. Considering the fault-tolerant operation of system, a fail-operational hardware architecture of the safety-related system is designed. Markov analysis shows that the safety integrity level (SIL) of safety-related systems can reach SIL3. Finally, experiments are designed to validate the proposed fault diagnosis and fault tolerance strategy. The results show that the safety-related system can effectively locate sensor failures, realize fault-tolerant control when a single sensor fails and perform safe torque off (STO) protection when multiple sensors fail.
A State-of-Art on the Development of Nafion-Based Membrane for Performance Improvement in Direct Methanol Fuel Cells
Authors: Ng Wei Wuen , Thiam Hui San , Pang Yean Ling , Chong Kok Chung , Lai Soon Onn
Published: May 2022

Nafion, a perfluorosulfonic acid proton exchange membrane (PEM), has been widely used in direct methanol fuel cells (DMFCs) to serve as a proton carrier, methanol barrier, and separator for the anode and cathode. A significant drawback of Nafion in DMFC applications is the high anode-to-cathode methanol fuel permeability that results in over 40% fuel waste. Therefore, the development of a new membrane with lower permeability while retaining the high proton conductivity and other inherent properties of Nafion is greatly desired. In light of these considerations, this paper discusses the research findings on developing Nafion-based membranes for DMFC. Several aspects of the DMFC membrane are also presented, including functional requirements, transport mechanisms, and preparation strategies. More importantly, the effect of the various modification approaches on the performance of the Nafion membrane is highlighted. These include the incorporation of inorganic fillers, carbon nanomaterials, ionic liquids, polymers, or other techniques. The feasibility of these membranes for DMFC applications is discussed critically in terms of transport phenomena-related characteristics such as proton conductivity and methanol permeability. Moreover, the current challenges and future prospects of Nafion-based membranes for DMFC are presented. This paper will serve as a resource for the DMFC research community, with the goal of improving the cost-effectiveness and performance of DMFC membranes.
Elastic Properties of Poly(ethylene glycol) Nanomembranes and Respective Implications
Authors: Zhao Zhiyong , Zharnikov Michael
Published: May 2022

Free-standing poly(ethylene glycol) (PEG) membranes were prepared from amine- and epoxy-terminated four-arm STAR-PEG precursors in a thickness range of 40–320 nm. The membranes feature high stability and an extreme elasticity, as emphasized by the very low values of Young’s modulus, varying from 2.08 MPa to 2.6 MPa over the studied thickness range. The extreme elasticity of the membranes stems from the elastomer-like character of the PEG network, consisting of the STAR-PEG cores interconnected by crosslinked PEG chains. This elasticity is only slightly affected by a moderate reduction in the interconnections at a deviation from the standard 1:1 composition of the precursors. However, both the elasticity and stability of the membranes are strongly deteriorated by a strong distortion of the network imposed by electron irradiation of the membranes. In contrast, exposure of the membranes to ultraviolet (UV) light (254 nm) does not affect their elastic properties, supporting the assumption that the only effect of such treatment is the decomposition of the PEG material with subsequent desorption of the released fragments. An analysis of the data allowed for the exclusion of so called “hot electrons” as a possible mechanism behind the modification of the PEG membranes by UV light.
Surface Modification of ETFE Membrane and PTFE Membrane by Atmospheric DBD Plasma
Authors: Ji Zuohui , Zhao Yue , Zhang Min , Li Xiaopeng , Li Heguo
Published: May 2022

Fluorine resin membranes with excellent chemical resistance have great potential for the application of high-performance chemical protective clothing. However, it is difficult to integrate fluorine resins into other materials such as fabrics due to their lower surface energy and poor bondability, making the fabrication of composite fabrics and the further seal splicing challenging. In this study, atmospheric pressure dielectric barrier discharge (DBD) plasma in helium (He) and helium/acrylic acid (He/AA) mixture atmospheres were used to modify two kinds of fluorine resins, ethylene tetrafluoroethylene (ETFE) and polytetrafluoroethylene (PTFE) membrane. The surface chemical properties, physical morphology, hydrophilicity and adhesion strength of the fluororesin membranes before and after plasma treatments were systematically analyzed. The results showed that the plasma treatment can modify the membrane surface at the nanoscale level without damaging the main body of the membrane. The hydrophilicity of the plasma-treated membrane was improved with the water contact angle decreasing from 95.83° to 49.9° for the ETFE membrane and from 109.9° to 67.8° for the PTFE membrane, respectively. The He plasma creates active sites on the membrane surface as well as etching the membrane surface, increasing the surface roughness. The He/AA plasma treatment introduces two types of polyacrylic acid (PAA)—deposited polyacrylic acid (d-PAA) and grafted polyacrylic acid (g-PAA)—on the membrane surface. Even after ultrasonic washing with acetone, g-PAA still existed stably and, as a result, improved the polarity and adhesion strength of fluororesin membranes. This work provides useful insights into the modification mechanism of DBD plasma on fluorine resins, with implications for developing effective strategies of integrating fluorine resin membrane to chemical protective clothing fabrics.
Effect of Grain Size on Mechanical and Creep Rupture Properties of 253 MA Austenitic Stainless Steel
Authors: Anwar Mochammad Syaiful , Widjaya Robert R. , Prasetya Leonardo Bayu Adi , Arfi Abdul Aziz , Mabruri Efendi , Siradj Eddy S.
Published: May 2022

The effect of grain size on the mechanical properties and creep rupture of 253 microalloyed (MA) austenitic stainless steel (ASS) was investigated. The cold rolling process with a 53% reduction in thickness was applied to the steel followed by annealing at 1100 °C over 0, 900, 1800, and 3600 s to obtain grain sizes of 32.4, 34.88, 40.35, and 43.77 µm, respectively. Uniaxial tensile and micro-Vickers hardness tests were carried out to study the effect of grain size on mechanical properties at room temperature. The creep rupture test was performed at 700 °C under a load of 150 MPa. The results showed that there was a correlation between grain size, mechanical properties, and creep rupture time. The fine initial grain size showed relatively good mechanical properties with a short creep rupture time, while the coarse initial grain size produced low mechanical properties with a long creep rupture time. The initial grain size of 40.35 µm was the optimum grain size for a high value of creep rupture time due to the low hardness and elongation values at room temperature and low creep ductility value. The intergranular fracture was found on the initial grain size below 40.35 µm, and a mixed mode of intergranular and transgranular fracture was found on the initial grain size above 40.35 µm after the creep rupture test.