bluuebunny/crossref_metadata_2025 huggingface dataset:
The effect of silymarin on diabetes mellitus-induced male rats reproductive impairment: Evidences for role of heat shock proteins 70 and 90
Authors: Hejazi S. , Rasekh M. , Taghdisi A. , Sabet A. , Maroufi MM. , Taghinasab S. , Bakhshi M.
Published: December 2024

Male fertility is adversely influenced by diabetes. The beneficial effects of antioxidant bioflavonoids in improving fertility have been reported. This study was conducted to evaluate the effects of silymarin on diabetes mellitus-induced male reproductive impairment in rats by investigating its role in Hsp70 and Hsp90 expression. To conduct this study, 18 mature male Wistar rats were divided into three groups: control (Con), experimental diabetes type 1 (T1D-sole)-induced, and silymarin (SMN, 120 mg/kg, orally)-treated T1D-induced groups. The testicular total antioxidant capacity (TAC) and malondialdehyde (MDA) levels were evaluated. Tubular differentiation index (TDI), repopulation index (RI), spermiogenesis index (SPI), and the Johnson score were also investigated. The DNA Ladder test was used to evaluate testicular DNA fragmentation, and RNA damage was assessed through fluorescent staining. Immunohistochemical and RT-PCR analyses were performed for Hsp70 and Hsp90. Oral administration of SMN significantly (p<0.05) increased the TAC ratio and decreased the MDA content in testicles compared to the T1D-sole group. The results showed that T1D increased the percentage of seminiferous tubules with negative TDI, RI, and SPI and reduced the Johnson score compared to the Con group (p<0.05). However, treatment with SMN ameliorated the T1D-induced damages to TDI, RI, SPI, and the Johnson score (p<0.05) compared to the T1D group (p<0.05). The staining intensities and the number of Hsp70+ and Hsp90+ cells were significantly higher in the Con group compared to the T1D-sole animals (p<0.05). However, rats treated with SMN showed an increased number of Hsp70+ and Hsp90+ cells per mm² of tissue compared to the T1D-sole group (p<0.05). Diabetes caused DNA fragmentation and RNA damage, but silymarin reduced its negative effects. In conclusion, SMN ameliorates T1D-suppressed spermatogenesis by upregulating testicular antioxidant status and Hsp70 and Hsp90 expression in testicular tissue. Consequently, it can be considered a potential complementary medication for male patients with T1D.
Assessment of The Self-Purifying Capacity of The Low Course of The River Pimenta, São Luís – MA
Authors: Maciel Gabriel Lira , Bandeira Vitória Lima , Pinheiro Estefanny Kaury Durans , Martins Renan Cavalcante , Silva Ericka Rarynne Dias da , Guimarães Pedro Vitor Baldez , Mendes Jonas Jansen
Published: December 2024

Objectives: To investigate the self-purification capacity of the Pimenta River in São Luís, Maranhão, in response to contamination by organic pollutants.
 
Theoretical Framework: Contamination of water bodies harms human health and ecosystems. Self-purification is a natural process that helps rebalance water after the introduction of pollutants, and is essential for assessing river recovery.
 
Method: The Streeter-Phelps model was used to assess dissolved oxygen (DO) and biochemical oxygen demand (BOD) levels in the river, performed in the laboratory, in addition to flow measurements.
 
Results and Discussion: The results showed that the Pimenta River has limitations in its self-purification capacity, with BOD and DO values ​​outside the legal parameters. This indicates that effluent discharges compromise water quality and affect the ecosystem.
 
Research Implications: The research highlights the need to improve water resource management and implement public policies to protect the local ecosystem and ensure water quality.
 
Originality/Value: The study offers an original analysis of the self-purification capacity of the Pimenta River, contributing to environmental management and public water protection policies in the region.
Tendências e desafios em torno da reforma agrária: um estudo de caso sobre os sistemas agroflorestais do projeto de desenvolvimento sustentável Milton Santos
Authors: Ferrauto Bondioli Francisco , Marchetti Fabio Frattini , Eduardo Moruzzi Marques Paulo
Published: December 2024

O objetivo da pesquisa consistiu em realizar um diagnóstico socioeconômico do PDS Milton Santos, região metropolitana de Campinas/SP, e identificar os traços centrais dos sistemas agroflorestais implantados no assentamento. Este último possui 70 lotes de 1 hectare cada, com cerca de 170 moradores. Parte importante da força de trabalho do assentamento, filhos e filhas entre 20 e 49 anos, não reside na comunidade, pois saíram em busca de empregos nos centros urbanos próximos. Cerca de 30% dos moradores realizam como principal ocupação a atividade agrícola (28 homens e 26 mulheres), a maioria com mais de 50 anos. A  principal produção local é  hortaliças. Oito famílias possuem SAFs em diferentes arranjos e desenhos: cinco com finalidade produtiva e três com finalidade ecológica. A pesquisa permitiu evidenciar que a comercialização dos produtos agroflorestais constitui o principal gargalo para mais investimentos nos SAFs. Por outro lado, a demanda de poda constante dos SAFs-horta é o principal motivo de insatisfação com o sistema. Apesar de ser uma iniciativa promissora e com potencial para aumentar a produção agroecológica do assentamento, muitos fatores representam obstáculos para sua adequada realização: capacidade de trabalho limitada; pouco conhecimento técnico ou prático acessível; indisponibilidade de ferramental adequado; insuficiência de planejamento e escolha pouco criteriosa de espécies arbóreas para os propósitos do SAF-horta, implicando em acentuados problemas ao longo do desenvolvimento desses sistemas.
Analisis Faktor Eksternal dan Internal Pada Perbankan Digital di Bursa Efek Indonesia: Studi Kasus Allo Bank
Authors: Muhammad Hemadanda , Soekarno Subiakto
Published: December 2024

Industri perbankan merupakan salah satu industri yang berkembang sangat pesat dan menarik di indonesia. Industri perbankan berkontribusi cukup signifikan pada ekonomi indonesia. Perkembangan industri perbankan tidak lepas dari ada nya pengaruh teknlogi dan adaptasi teknologi yang masif di indonesia. industri perbankan mulai membuat model bisnis dan bentuk baru yaitu Bank digital. Bank digital di indonesia sempat menarik banyak perhatian karena teknologi baru yang dibawa dan kinerja saham bank digital yang naik secara signifkan pada tahun 2021. Kenaikan harga saham bank digital tidak berlanjut hingga tahun berikutnya dan terus mengalami penurunan. Salah satu bank digital yang mengalami penurunan harga saham signifikan adalah allo bank. Allo bank mengalami penurunan saham yang signifikan meskipun performa allo bank naik secara signifikan. Penelitian ini akan melakukan studi analisa eksternal dengan menggunakan metode PESTEL dan Porter's five force untuk melihat kondisi makro dan industri dari perbankan di indonesia dan melakukan analisa internal menggunakan risk based bank rating untuk melihat kinerja dan kesehatan bank. Analisa eksternal menunjukan bahwa makro dan industri perbankan menunjukan peluang positif untuk allo bank berkembang dan analisa internal menunjukan allo bank memiliki kinerja yang sangat baik di antara bank digital lainnya
Escritoras marfileñas de la A a la Z
Authors:   Universidad de Cádiz  (España), Cuasante Fernández Elena
Published: December 2024

Conceived as a complementary contribution to this monograph, «Ivorian women writers from A to Z» aims to be a useful introduction to literature written by women in Côte d’Ivoire. With almost half a century of history, this literature has been evolving towards a greater variety of cultivated genres, themes and even artistic formats, which is good proof of its dynamism. After a first section summarising the main lines of this evolution, an exhaustive and updated bibliographical repertory has been compiled, which can serve as a basis for future research activities.
La femme du Blanc de Muriel Diallo : une quête identitaire polyphonique
Authors:   Universidad de Granada (España), Guzmán-Pérez Juan José
Published: December 2024

This article analyses the novel La femme du Blanc (2011) by Muriel Diallo through a polyphonic lens. It aims to demonstrate how the narrator, Astaï, through the quest for the dentity of her grandmother Beautiful, conveys the voices and perspectives of other migrant women in France, who become anchors of identity. The multiplicity of narrative instances reflects the diverse challenges faced by contemporary African women. Throughout her odyssey, Astaï evolves into the spokeswoman for her «street sisters» as well as for her own past. By sharing the «boxes» they open, the voices and enunciations in the story manage to reconcile with their own identity.
Tanella Boni a son mot à dire
Authors:   Universidad de Cádiz, Sánchez Tocino Elisabet , Cuasante Fernández Elena ,   Universidad de Cádiz (España)
Published: December 2024

Tanella Boni, one of the best-known voices on the Ivorian literary scene, answers some questions related to her literary creation and her personal concerns about the future of her country and the black content in an interview conducted in the spring of 2024. Many of the questions are related to the female universe, and more specifically to the new forms of oppression that African women have to face.
Oralité et stratégies énonciatives dans Le déterreur de Mohammed KhairEddine
Authors:   Université Sidi Mohammed Ben Abdellah (Marruecos), Abejja Ismail
Published: December 2024

In Mohammed Khair-Eddine’s novel Le Déterreur (The CorpseDigger, 1973), the protagonist is a corpse digger who commits appalling acts in a devastated region by poverty and drought. In his cell, awaiting execution, he replayed certain painful scenes of his life, directing his venom at society, politicians and the world around him. According to that, an enunciative approach, allows to perceive the oral and volcanic dimension in Khair-Eddine’s writing manifests in a literary discourse to turns the novel into a text denouncement the socio-political reality and world touch of originality to the writing of Khair-Eddine, would hoped to create a new language characterized by violence and heartbreak.
La interculturalidad en Lengua y Lingüística del Grado en Estudios Franceses de la Universidad de Granada
Authors:   Universidad de Granada (España), García Romero Marta , Ruyffelaert Ariane ,   Universidad de Granada (España)
Published: December 2024

The article takes us on a journey through the French Language and Linguistics subjects in the Bachelor’s Degree in French Studies at the University of Granada, in order to identify the presence of the (inter)cultural dimension. The study of scientific literature and teaching guides enabled us to determine which type of culture is worked on the most. This work is based on the types of culture proposed by Oliviéri (1996), which serve as a filter in the research. Thus, the anthropological culture and the globalizing culture, as defined by Oliviéri (1996), are the protagonists, showing that teaching this skill is key to students’ personal and social growth.
Gammes fréquentielles optimales : Indices de progression en perception exolingue
Authors:   Universitat de València  (España), Lopez-Garcia Patricia
Published: December 2024

The research is part of a longitudinal study comparing the perception processes of Catalan-speaking trilingual subjects (L0 Catalan, L1 Spanish and L2 French) and university students of FLE. The identification of the optimal frequency ranges considered as phonetic categorical reference points of a linguistic system in the two groups makes it possible to compare their perceptual spaces and to determine whether the variable “language exposure time” can have an impact on the students’ perception and help them to come closer to the perceptual model of the Catalan-speaking trilingual subject. The experimental analysis, based on a comparison of the optimal frequency ranges of the two groups over two years, suggests that these could be considered as markers of linguistic progress.
Religieuses en voyage (1604-1727) : le travail de la description dans leurs récits fondationels
Authors:   Universidad de las Islas Balear (España), Vicens-Pujol Carlota
Published: December 2024

Since the Council of Trent (1563), the foundations of convents of different Orders multiplied in Europe; Many nuns undertook long journeys to found, either in other French cities or in New France. This article aims to analyze some of them left writings of those journeys under the Ancien Régime, placing emphasis on the treatment of the description. This is especially interesting because, during their journey, the nuns had to maintain the cloister: descriptions of the exterior space are thus scarce, while those of interior spaces, especially the consecrated interiors, acquire special relevance. There will also be an analysis of the figure of the Other, whether savage or heretic.
Частные и публичные начала в страховании урожая, осуществляемом с государственной поддержкой
Authors: Молчанов А.А.
Published: December 2024

Рассматриваются правоотношения в сфере страхования урожая, осуществляемого с государственной поддержкой, на предмет выявления тех методов правового регулирования, которые определяют суть данных правоотношений. Обосновывается подход, в соответствии с которым указанные правоотношения определяются как комплексные, урегулированные как частноправовым, так и публично-правовым методом правового регулирования; в этих отношениях субъектами выступают не только страховщик и страхователь, но и государство как самостоятельный субъект, чьими властными решениями обеспечивается стабильность изучаемых правоотношений.

Legal relations in the field of crop insurance, carried out with state support, are considered in order to identify those methods of legal regulation that determine the essence of these legal relations. The approach is substantiated, according to which these legal relations are determined by complex, regulated by both private law and public law methods of legal regulation; in these relations, the subjects are not only the insurer and the policyholder, but also the state, as an independent entity, whose power decisions ensure the stability of the studied legal relations.
К вопросу о соотношении частной инициативы и предпринимательства
Authors: Стёпин А.Б.
Published: December 2024

Предпринимательство и частная инициатива в условиях формирования рыночных отношений характеризуются с разных позиций. Во-первых, частная инициатива, обладающая экономическим и правовым содержанием, рассматривается как регулятор предпринимательской и иной не запрещенной законом экономической деятельности и как условие осуществления субъективных гражданских прав предпринимателей. Во-вторых, частная инициатива в условиях ее позитивного выражения является средством защиты гражданских прав предпринимателей. В целом предпринимательство и частная инициатива являются комплексными, многоотраслевыми и функциональными по своему содержанию и назначению понятиями. Автор приходит к выводу о том, что правовое регулирование предпринимательства и частной инициативы осуществляется с исходной (базисной) позиции и специальной (ситуационной) позиции, выраженных в законе, договоре, обычае и судебной практике.

Entrepreneurship and private initiative in the context of the formation of market relations are characterized by several positions. First, having an economic and legal content, private initiative is considered as a regulator of entrepreneurial and other economic activities not prohibited by law, as a condition for the implementation of the subjective civil rights of entrepreneurs. Secondly, private initiative in terms of its positive expression is a means of protecting the civil rights of entrepreneurs. In general, entrepreneurship and private initiative are complex, multi-sectoral and functional concepts in their content and purpose. The author comes to the conclusion that the legal regulation of entrepreneurship and private initiative is carried out from several positions, initial (basic), special (situational), expressed in law, contract, custom and judicial practice.
Применение ударных беспилотных комплексов в контртеррористических операциях
Authors: Красинский В.В.
Published: December 2024

Рассматривается проблема правового регулирования применения ударных беспилотных комплексов в контртеррористических операциях. Автор раскрывает вопросы применения ударных беспилотных летательных аппаратов в условиях правового режима экстерриториальных и внутригосударственных контртеррористических операций. Обосновывается необходимость регламентации базовых принципов применения ударных беспилотных летательных аппаратов, отбора и идентификации боевых целей, гарантий защиты гражданского населения, вопросов юридической ответственности и возмещения вреда.

The article addresses the problem of legal regulation of the use of strike unmanned systems in counter-terrorist operations. The author discloses the issues of the use of attack unmanned aerial vehicles in the conditions of the legal regime of extraterritorial and domestic counter-terrorist operations. The necessity of regulating the basic principles of the use of attack unmanned aerial vehicles, the selection and identification of combat targets, guarantees for the protection of the civilian population, issues of legal liability and compensation for harm is justified.
О некоторых вопросах соотношения предмета и метода правового регулирования
Authors: Рыженков А.Я.
Published: December 2024

Статья посвящена предмету и методу правового регулирования. Отмечается, что обусловленность правового регулирования свойствами его предмета, т. е. общественных отношений определенного типа, является общим местом в российской юридической науке. Вместе с тем налицо некоторое противоречие: предмет правового регулирования в большинстве случаев выступает уже в таком качестве, в котором его формально-юридические свойства неотделимы от социально-экономических. Иллюстрацией может служить понятие гражданского оборота, который, с одной стороны, рассматривается как вид объективно существующей социальной практики, а с другой стороны, неизбежно несет на себе отпечаток правового воздействия, так что предмет регулирования «в чистом виде», лишенный юридического аспекта, нигде не встречается, а значит, сам по себе и регулированию не подлежит. Данью традиции является также деление права на частное и публичное. Однако анализ действующего нормативного материала показывает, что эта дихотомия не имеет никакого отношения к отраслевой структуре права, а фиксирует лишь чисто условные конгломераты норм, не локализованные ни в каких официальных формах. Континуальность как характеристика метода правового регулирования, выражающая его направленность на достижение единства правового пространства преимущественно через нейтральные описательные модели, не сводима к диспозитивности или дозволительности, а представляет собой альтернативу этим явлениям.

The article is devoted to the subject and method of legal regulation. It is noted that conditionality of legal regulation by properties of its subject, i.e. public relations of certain type, is a common place in Russian legal science. However, there is a certain contradiction: the subject of legal regulation in most cases acts already in the capacity where its formal-legal properties are inseparable from socio-economic ones. An illustration is the concept of civil turnover, which, on the one hand, is considered as a type of objectively existing social practice, and on the other hand, inevitably bears the imprint of the legal impact, so that the subject of regulation "in its pure form", devoid of a legal aspect, is not found anywhere, and therefore is not subject to regulation per se. The division of law into private and public is also a tribute to tradition. However, an analysis of the current normative material shows that this dichotomy has nothing to do with the branch structure of law, but fixes only purely conventional conglomerates of norms that are not localized in any official forms. Continuity as a characteristic of the method of legal regulation, expressing its focus on achieving the unity of the legal space mainly through neutral descriptive models, is not reducible to dispositiveness or permissiveness, but is an alternative to these phenomena.
О правовом статусе государственных и негосударственных судебно-экспертных организаций
Authors: Матвеев И.В.
Published: December 2024

Рассматривается проблематика правового статуса государственных и негосударственных судебно-экспертных организаций. Автор обращает внимание на недостаточное правовое обеспечение деятельности негосударственных судебно-экспертных организаций, в отличие от государственных. Обладая широкими возможностями осуществления экспертной деятельности в соответствии с действующим законодательством, негосударственные судебно-экспертные организации не имеют на сегодняшний день единых государственных требований к функционированию, включая требования к экспертам. Кроме того, отсутствуют процедура отбора негосударственных судебно-экспертных организаций для проведения судебных экспертиз, связанных с публичными отношениями, а также механизм оплаты этих экспертиз из средств государственного бюджета. В заключительной части статьи автор вносит конкретные предложения по совершенствованию правового статуса негосударственных судебно-экспертных организаций.

The problems of the legal status of state and non-state forensic organizations are considered. The author draws attention to the insufficient legal support for the activities of non-governmental forensic organizations, in contrast to state ones. Possessing wide opportunities for carrying out expert activities in accordance with the current legislation, non-state forensic organizations do not currently have uniform state requirements for functioning, including requirements for experts. In addition, there is no procedure for selecting non-governmental forensic organizations to conduct forensic examinations related to public relations, as well as a mechanism for paying for these examinations from the state budget. In the final part of the article, the author makes specific proposals for improving the legal status of non-governmental forensic organizations.
К вопросу о правовом регулировании статуса постоянных комиссий представительных органов местного самоуправления
Authors: Вихарев А.А.
Published: December 2024

Анализируются особенности правовой регламентации роли и места постоянных комиссий в системе представительного органа муниципального образования. Формулируется вывод, что эта регламентация лишена централизованных начал, поскольку полностью находится в ведении местной представительной власти и носит в настоящее время децентрализованный муниципально-правовой характер.

The features of the legal regulation of the role and place of standing committees in the system of the representative body of the municipality are analyzed. The conclusion is formulated that it is devoid of centralized principles, since it is completely under the jurisdiction of local representative power, and is currently decentralized - municipal-legal in nature.
Судебная практика признания недействительными сделок банков, влекущих за собой оказание предпочтения одному из кредиторов перед другими кредиторами.
Authors: Быков В.П. , Черникова Е.В. , Маркелова И.В.
Published: December 2024

Представленная вниманию читателя статья продолжает цикл авторских материалов о различных аспектах правового регулирования в сфере арбитражного судопроизводства. В статье анализируются правовые основания недействительности совершенных банками сделок, влекущих за собой оказание предпочтения одному из кредиторов перед другими кредиторами. На основе исследований арбитражной практики авторы показывают ошибки, допускаемые при признании недействительными сделок банков, совершаемых с предпочтением.

The article presented to the reader's attention continues the series of author's materials on various aspects of legal regulation in the field of arbitration proceedings. The article analyzes the legal grounds for the invalidity of transactions made by banks, which entail giving preference to one of the creditors over other creditors. Based on the research of arbitration practice, the authors show the mistakes made when invalidating bank transactions made with preference.
Свойство законности судебного решения в гражданском процессе
Authors: Марченко Е.В.
Published: December 2024

Автором поставлена цель исследовать и раскрыть основное свойство, которым должно обладать правильное решение суда. Для этого анализируются недостатки судебного решения, ошибки суда, которые могут являться основанием для отмены или изменения судебных постановлений, принятых при разрешении спора по существу. Помимо метода анализа в исследовании использованы логический и гипотетический методы. Сформулирован вывод о том, что законность как свойство судебного решения включает в себя правильное применение норм процессуального и материального права, включая надлежащее истолкование судом норм права с обязательным учетом правовых позиций Верховного Суда Российской Федерации, Конституционного Суда Российской Федерации и, в допустимых законом случаях, Европейского суда по правам человека.

The author aims to investigate and reveal the main property that a correct court decision should have. To do this, we analyze the shortcomings of the decision, the errors of the court, which may be the basis for the cancellation or modification of court decisions adopted in resolving the dispute on the merits. In addition to the analysis, logical and hypothetical methods were used. The conclusion is formulated that legality, as a property of the decision, includes the correct application of the rules of procedural and substantive law, including the proper interpretation of the law by the court, with mandatory consideration of the legal positions of the Supreme Court of the Russian Federation, the Constitutional Court of the Russian Federation and, in cases permissible by law, the European Court of Human Rights.
ОСОБЕННОСТИ ПОЛУЧЕНИЯ ПОЛИГЛИЦЕРИНА И ЕГО СЛОЖНЫХ ЭФИРОВ С ЖИРНЫМИ КИСЛОТАМИ
Authors: Кюрегян Г.П. , Комаров Н.В. , Кюрегян О.Д.
Published: December 2024

Рассмотрены особенности процесса получения полиглицерина и его эфиров с насыщенными и ненасыщенными жирными кислотами, а также приведен анализ реакции полимеризации глицерина, условия проведения которой - решающий фактор для производства высококачественного продукта - пищевой добавки «Сложный эфир полиглицерина» (Е475). Представлена практическая значимость и наиболее известные направления применения эмульгатора Е475.

The features of the process of obtaining polyglycerin and its esters with saturated and unsaturated fatty acids are considered, and the analysis of the glycerol polymerization reaction is also given, the conditions of which are a decisive factor for the production of a high-quality product - the food additive «polyglycerin ester» (E475). The practical significance and the most well-known applications of the emulsifier E475 are presented.
A Chinese view of service management in the digital age. A review of the book “The Era of New Services” (Springer, Citic Press, 2024)
Authors: Ruban D. A.
Published: December 2024

The service sector is gradually beginning to dominate modern economy, while qualitatively changing in the context of digital transformation. The article is a review of a monograph by a well-known Chinese specialist, which notes an original view of the above-mentioned issue. The latter is conceptualized and considered on a variety of examples (from the experience of China and other countries). The book consists of four unequal parts, which include a total of 11 chapters. The author consistently characterizes service activities essence, highlights the main prospects for service innovations, identifies the possibilities of developing the latter, and also draws attention to the importance of considering a modern person’s preferences in depth. Considerable attention has been paid to the proposed SERVINO system, which makes it possible to increase managing innovative processes efficiency in the service sector. The monograph suggests that digital transformation will not overshadow personality (both a client and an employee), but, on the contrary, will allow considering a person’s interests in the most careful way. The book is written in simple language, it is full of factual information. Its content analysis shows that it can be considered as a universal source of information about service activities management in the digital age that has already begun. A clearly expressed author’s attitude to the issue does not reduce, but, on the contrary, increases the value of this source. At the same time, the monograph marks the undoubted successes of the Chinese economic thought development.
Electron-deficient Alkyne Lipids Enable Efficient Synthesis of Comparable Polymer Lipids via Copper-free Azide-Alkyne Cycloaddition
Authors: Kaps Florian T. , Ziegler Anna-Lena , Fritsche Paul , Takmakova Ekaterina , Kerr Andrew , Boye Susanne , Lederer Albena , Luxenhofer Robert
Published: December 2024

Polymer lipids (PLs) are essential components of liposomes and lipid nanoparticles (LNPs) for drug and gene delivery, providing colloidal stabilization and defining the biological interface. While poly(ethylene glycol) (PEG)-based PLs are the current standard, they are suspected to be responsible for rare adverse reactions, e. g. to LNP-based Covid-19 vaccines. Therefore, PLs based on alternative stealth polymers are being intensively investigated for their use in LNPs. However, alternative PLs often lack comparability due to different synthesis protocols and are often not easily accessible. Herein we present a catalyst-free, efficient and versatile coupling procedure for PL synthesis based on azide-functionalized polymers and electron-deficient acetylene dicarboxylate lipids. To highlight the versatility of this approach, we prepared PLs based on PEG and 4 alternative stealth polymers with quantitative coupling efficiencies. The linker structure showed appropriate pH stability and all PLs enabled the preparation of well-defined liposomes with excellent stability. Our facile and versatile approach yields comparable PLs with minimized linker size, making them promising candidates for future comparative studies and biomedical applications.
Total Synthesis of Cafestol from ent-Kaurenoic Acid
Authors: Kharel Rupak , Almazrua Rakan , McDonald Tristan , Stevenson Amberly , Mighion Jeffrey
Published: December 2024

Herein, we present the total synthesis of cafestol, a diterpene from commercially available stevioside, in 19 steps with an overall yield of 1.59 %. This synthesis provides a rapid and scalable entry to the ent-kaurene skeleton and, finally, cafestol through early dihydroxylation and late-stage furan ring construction. A key feature of this synthesis is the intro-duction of the furan ring via an oxa-Michael-Wittig annulation using a vinyl phosphonium salt on an -hydroxy ketone substrate. This paper also highlights the extraction of ent-kaurenoic acid from sunflowers and describes its synthesis toward cafestol in 14 steps.
Size-transferable prediction of excited state properties for molecular assemblies with machine-learned exciton model
Authors: Ren Fangning , Chen Xu , Liu Fang
Published: December 2024

Computational modeling of the excited states of molecular aggregates faces significant computational challenges and size heterogeneity. Current machine learning (ML) models, typically trained on specific-sized aggregates, struggle with scalability. We found that the exciton model Hamiltonian of large aggregates can be decomposed into dimer pairs, allowing an ML model trained on dimers to reconstruct Hamiltonians for aggregates of any size. We trained an ML model on perylene dimer exciton Hamiltonians using quantum chemistry descriptors to resolve phase correction issues. Our model accurately predicted excitation energies and oscillator strengths in perylene trimers and tetramers, and analyzed the size-dependent optical bandgap in aggregates with up to 50 monomers, revealing quantum dot-like confinement effects. Future work will explore transferability across different monomers to predict optical properties in heterogeneous assemblies.
Gestión de Calidad de Servicio y Desempeño Profesional: Nuevas Perspectivas de Gestión por Procesos de un Hospital Público Peruano
Authors: Goicochea Tipismana Magali K.
Published: December 2024

This study analyzes the correlation between service quality management and professional performance in a Peruvian public hospital from a process management perspective. A quantitative, correlational and cross-sectional design was used with a census sample of 70 health professionals working in the Santa Rosa Hospital (MINSA). The data, collected by means of a validated questionnaire with high reliability (α = 0.906 and α = 0.929), were analyzed with Kolmogorov-Smirnov and Spearman's rho tests. A moderate positive correlation was found between the variables service quality management and professional performance (rho = 0.589; P < 0.001); in addition, service quality management presented moderate correlations with service delivery, job satisfaction and effectiveness (rho = 0.495, 0.550 and 0.570; P < 0.001) and a weak correlation with job satisfaction (rho = 0.348, P. 003). It is concluded that effective quality management can improve professional performance, although limitations such as cross-sectional design and the need to integrate new technologies were identified. It is recommended that training and modernization strategies be implemented to optimize hospital processes
Situación del cáncer en el Perú
Authors: Oropeza Indyra
Published: December 2024

Para quienes no lo conocen, el "Semáforo Oncológico" es una iniciativa de la sociedad civil, conformada por 10 asociaciones de pacientes. Nuestro principal objetivo es comunicar y alertar sobre el avance de la implementación de la Ley Nacional de Cáncer. Desconozco si todos tienen la presentación a la mano, yo no puedo visualizarla, pero me gustaría compartir algunas cifras relevantes del cáncer en nuestro país.
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Finalmente, a los tomadores de decisiones aquí presentes, les pido que tomen acciones ahora. Como paciente oncológica en tratamiento, sé que el sistema no funciona como debería. Si no mejoramos, seguirá fallando a muchos más. Es urgente actuar en beneficio de los más de 175,000 pacientes oncológicos en Perú.
Ironic opinions on Polish Reddit: Description and computational methods of analysis
Authors: Bączkowska Anna , Kukowicz-Żarska Katarzyna , Dłutek Aneta , Benenowska Iwona
Published: December 2024

The paper analyses ironic comments as forms of expressing opinions posted by social media users, specifically on Polish Reddit. The study resorts to Gricean and neo-Gricean theories and typologies adapted to analyse the (syntactically) imperfect, spontaneous and colloquial discourse used online on social media. In this analysis, various corpus and computational tools are deployed to scrutinise types of irony, topics, and functions. The results have clearly shown that the most frequent type of irony used by Reddit authors is lexical irony, the predominant function is jocular irony, and the overall sentiment of the comments is negative. Ironic comments on the Polish Reddit (subreddit ‘/s’) are primarily used to express opinions about institutions, events, things and generally the third party, and rarely to attack an individual. The study also shows how advanced computational tools available for the Polish language can be used in a language analysis of opinionated texts.
Gamification as a method supporting the adaptation of first-year students to the university life
Authors: Jędrzejczak Małgorzata
Published: December 2024

The phenomenon of mass student attrition before graduation is a pressing challenge faced by universities globally, including those in Poland. Between 2012 and 2020, over 1.3 million individuals withdrew from Polish universities, failing to resume their studies within a year of deregistration. Notably, the highest dropout rates – up to 70 % –occur within the first two semesters of study. This trend is driven by a confluence of individual factors, such as a lack of interest in the chosen field of study or personal difficulties, and institutional factors, including curriculum design and the pedagogical competencies of ac-ademic staff. A key determinant of student retention is the ability to adapt to the distinct norms and expectations of academic life. The suc-cessful transition of first-year students to university life is crucial for their subsequent personal and professional development. However, many first-year students struggle with high academic standards, an extensive curriculum, difficult subjects, and monotonous theoretical lectures. Addressing dropout rates necessitates pedagogical reforms, including the adoption of more active teaching methods that promote student engagement, foster critical thinking, and enhance problem- solving skills. Such reforms empower students to take greater respon-sibility for their learning, thereby improving their academic experience and retention.
The objective of the project conducted under the Masters of Didac-tics – Advanced Program was to develop a method aimed at increasing student engagement and improving academic performance among first-year students in an engineering program at Lodz University of Technology. The introduction of gamification elements in one of the courses led to a marked improvement in student attendance and heightened willingness to undertake additional challenges. Although the impact of these modifications on students' final academic achieve-ments yielded mixed results, gamification demonstrates significant potential as an effective strategy, particularly for first-year students, to enhance engagement and support their adaptation to the academic environment.
A wise man changes his mind, a fool never will: From the idea of gamification to breaking the barriers of passive student behaviours that stem from a fear of making mistakes
Authors: Nowak Bożena
Published: December 2024

This article presents the findings and conclusions from a course gam-ification initiative conducted as part of the Masters of Didactics teach-ing program. The primary objective of the course modification was to employ gamification in selected classes to address and counteract stu-dents’ passive attitudes. The classes involved both Polish and interna-tional first-year Master's students in biology and biotechnology. Gam-ification was applied specifically to laboratory sessions, during which students developed fictitious start-ups aimed at addressing pressing environmental challenges. The initial outcomes revealed that a signif-icant barrier to active participation in the gamified module was the students’ fear of making mistakes. Consequently, it was decided to adopt a more supportive approach towards the students throughout the semester. As a result, students were provided with a learning en-vironment where mistakes were viewed as opportunities for growth. Over time, this shift in approach led to increased openness and active participation among students. Despite several initial challenges, the course modification produced notable results, including 100 % attend-ance and heightened engagement, particularly among international students. These results underscore the potential of gamification, cou-pled with supportive teaching methods, in effectively educating both Generation Z and future Alpha students.
Atividade turística nas orlas: interferências, particularidades e a qualidade dos serviços de alimentos e bebidas da praia de Ponta Negra, Natal/RN, Brasil.
Authors: Virginio Darlyne Fontes , Alves Josemery Araújo , Santos Kaline Mendonça dos , Marques Júnior Sérgio
Published: December 2024

A qualidade nos serviços de A&B é um fator importante para a satisfação dos turistas. Compreendendo a diversidade de interferências e particularidades por meio do turismo nas orlas, esse estudo teve como objetivo geral “identificar como os turistas avaliam os serviços de alimentos e bebidas ofertados na praia de Ponta Negra, em Natal/RN”, contando com os seguintes objetivos específicos: conhecer o perfil dos turistas que frequentam a praia de Ponta Negra; compreender, na visão dos turistas, a qualidade (comercial, tangível e intangível) dos serviços de alimentos e bebidas da praia; e propor, a partir de tais percepções, apontamentos para uma melhor gestão dos serviços nos estabelecimentos de A&B da praia de Ponta Negra. A pesquisa utilizou-se da triangulação de dados, com destaque para a abordagem quantitativa, com uma amostra de 172 turistas que responderam a um questionário contendo 22 questões, um dos critérios era ter consumido os serviços de A&B ofertados na praia, lócus do estudo. Para analisar os dados utilizou-se o software Statistical Package for the Social Sciences (SPSS), versão 22.0. Sobre o perfil dos investigados na pesquisa, em sua maioria, jovens e adultos, predominando renda familiar superior a três salários mínimos, com representação de todas as regiões do Brasil. Os turistas, de um modo geral, atribuíram notas 07 e 08 (41,86%) e 09 e 10 (44,76%) para a qualidade dos serviços ofertados pelos estabelecimentos de A&B. Os resultados mostraram que todas as variáveis que compõem a dimensão de qualidade comercial, tangível e intangível apresentaram valores de média favoráveis, indicando um nível de concordância positivo com os serviços prestados em Ponta Negra. Recomenda-se que os estabelecimentos de A&B sejam melhor acompanhados, assistidos e incluídos nas ações de planejamento participativo, integrado e responsável, rumo a uma gestão eficiente do turismo na praia de Ponta Negra.
Relação da gestão da informação e lei geral de proteção de dados pessoais
Authors: Oliveira Alanna Siqueira Simonetti , Gallotti Mônica Marques Carvalho , Barbosa Neto Pedro Alves
Published: December 2024

Este artigo versa acerca da análise das correlações e implicações recíprocas existentes entre a gestão da informação e a Lei Geral de Proteção de Dados. Tem como objetivo realizar uma pesquisa bibliográfica e bibliométrica com vistas a verificar como ambos os assuntos estão sendo debatidos e incorporados à literatura cientifica da Ciência da Informação. Para efetivar a referida mensuração, foi realizada uma revisão bibliográfica acerca dos assuntos tratados, bem como uma análise bibliométrica utilizando os termos de busca “gestão da informação AND Lei Geral de Proteção de Dados” na base de dados Dimensions almejando aferir como se comporta a produção acadêmica acerca dessa temática. A pesquisa evidenciou que há indícios de correlação a partir da produção científica a despeito de essa se apresentar ainda incipiente e bastante dispersa. Concluiu-se ainda acerca da existência de implicações recíprocas que perpassam a utilização das práticas de gestão documental para otimização da aplicação dos parâmetros da Lei Geral de Proteção de Dados, bem como se consolidou o entendimento de que a aplicação da referida lei a despeito de se perfazer um desafio, efetiva uma mudança paradigmática que enseja o aprimoramento da gestão da informação. Assim, defende-se a necessidade de pesquisas futuras em que seja investigada a convergência entre os referidos temas de modo atingir maior maturidade de compreensão, propiciando aos estudiosos da área uma análise mais fidedigna.
O Turismo como instrumento ideológico velado
Authors: Montserrat Breno , Guimarães Santos de Oliveira Ana Paula
Published: December 2024

Uma imagem vale mais que mil palavras, é o que muitos costumam dizer. Entretanto, na presente pesquisa tal afirmação passa a ser questionada. O trabalho parte do contexto de retomada das políticas públicas voltadas ao turismo, em plena ditadura civil-militar de 1964, com a criação da Empresa Brasileira de Turismo (EMBRATUR) em 1966. Em meio a um cenário fascista de brutalidade, censura e opressão, uma nova atividade surge, com a promoção de um país belo e descolado da realidade. Partindo da premissa que o turismo estava alinhado e foi utilizado como ferramenta para reforçar o discurso da ditadura, marcadamente o discurso da integração nacional, foi analisado um folder promocional da região Nordeste. Esta região, que juntamente com a Amazônia, por muitos anos foram as localidades mais divulgadas pela EMBRATUR. O objetivo foi compreender como as sete imagens que compõem o material promocional selecionado foram utilizadas para fomentar a ideologia pregada pelo regime militar, evidenciando o que elas escondem e a mensagem que desejam transmitir. As imagens foram analisadas considerando sua forma de conteúdo, como proposto por Mauad (1996) e os três elementos que constituem uma fotografia segundo Kossoy (2001), o assunto, o fotógrafo e a tecnologia. Como resultado, evidencia-se a utilização do turismo com forte viés ideológico, utilizado na construção da narrativa de uma identidade nacional. As fotografias promocionais do Nordeste apontam para a ideia de miscigenação pacífica entre indígenas, negros e brancos, constituindo o queria seria uma “brasilidade”.
Deficiena: a Fotocolagem como Prática Etnográfica da Deficiência
Authors: Teixeira Bruna , Aureliano Olga , Lee Malta
Published: December 2024

As fotocolagens apresentadas neste encarte visual fazem parte do acervo criado durante a pesquisa de mestrado Deficiena, que propõe a deficiência como uma potência cocriativa para a fabricação da imagem etnográfica. Para tanto, examina a prática da fotocolagem digital como experiência do encontro com Olga Aureliano, Vanessa Malta, Aline Regina, Helen Costa e Edvânia - alagoanas com deficiência residentes em Maceió/AL, e cujos processos foram vividos a partir de deslocamentos dinâmicos bem particulares. A análise considera uma atenção especial: 1) ao tempo dedicado a instância visual da fotocolagem; 2) aos excessos de edição digital como maneira de “abrir” a imagem do campo e 3) às cumplicidades existentes em uma campanha etnográfica engajada e feminista da deficiência, vivida para frente, numa relação dialógica e inventiva que evoca um encontro do lugar artístico autoral, com produção que visualiza o endógeno – as parceiras defiças - , mas não deixam de existir como criação exógena – da parceira antropóloga artista, lésbica e temporariamente não-defiça.  Em torno de seguir pensando as imagens, sem perder de vista os pensamentos que elas próprias articulam, a pesquisa traz citações em autorretratos e referências imagéticas de artistas ativistas da deficiência, bem como, das inspirações analíticas sobre retratos clássicos de Rosemarie Garland-Thomson, dos estudos das últimas décadas sobre a relação da imagem como experiência etnográfica e do conjunto de textos que articulam a reflexão teórica da pesquisa com e por pessoas com deficiência na antropologia brasileira.
Novas tendências na Antropologia Visual: etnografias multimodais, arte e epistemologias plurais
Authors: Alvarez Gabriel Omar , Athias Renato , Rivera Mariana
Published: December 2024

Apresentação do dossiê "Novas tendências na Antropologia Visual: etnografias multimodais, arte e epistemologias plurais".
Corporalidade abjeta: reflexões sobre o cuidado a mulheres que fazem uso de drogas
Authors: Martins Karoliny Felipe
Published: December 2024

Este artigo buscou analisar as dinâmicas do cuidado a mulheres que fazem uso de drogas. Para isso, tomei como ponto de partida a análise do caso de Isabel, quem acessa um serviço religioso a fim de solucionar o seu problema com o álcool. A partir disso, uma rede de cuidado é mobilizada considerando uma identidade interseccional, um corpo abjeto e feminino, o que propõe refletir sobre as dimensões de cuidado com demandas específicas que emergem quando outras categorias identitárias são elencadas. A discussão é construída, metodologicamente, por meio de uma entrevista semi-estruturada e apoiada por revisão de literatura antropológica.