bluuebunny/crossref_metadata_2025 huggingface dataset:
Effects of Variable-Temperature Roasting on the Flavor Compounds of Xinjiang Tannur-Roasted Mutton
Authors: Wei Jian , Wang Li , Ma Xin , Xu Zequan , Wang Zirong
Published: September 2024

This study investigates the effect of variable-temperature roasting on the flavor compounds of Xinjiang tannur-roasted mutton. Gas chromatography coupled with ion mobility spectroscopy (GC-IMS) was used to compare and analyze the volatile components and flavor fingerprints of Xinjiang tannur-roasted mutton using variable-temperature electrically heated air roasting (VTR), constant-temperature electrically heated air roasting (EHAR), and constant-burning charcoal roasting (BCR) techniques. The changes in fatty acids and free amino acids in Xinjiang tannur-roasted mutton under different roasting conditions were compared. By using GC-IMS analysis, 11 flavor compounds, including 4-methyl-3-penten-2-one, isoamyl propionate, trans-2-heptenal, trans-2-heptenal, 2-hexanone, n-hexanol, 2-hexenal, 2-ethylfuran, and ethyl 2-methylbutanoate, were identified as characteristic volatile compounds in the temperature-controlled electrothermal roasting of Xinjiang tannur-roasted mutton using the following conditions: 0–4 min, 300 °C; 5–10 min, 220 °C; and 11–17 min, 130 °C (VTR3). Through principal component analysis, it was found that the substances with the highest positive correlation with PC1 and PC2 were n-hexanol and 3-methylbutanol. The sensory evaluation showed that VTR3 had high acceptability (p < 0.05) and a fat flavor (p < 0.05). There was no significant difference in the total fatty acid (TFA) content between the VTR3 and burning charcoal roast for 1–17 min at 300 °C (BCR3) (p > 0.05), but it was lower than that in the other experimental groups (p < 0.05). The lowest proportion of glutamic acid content in VTR3 was 22.44%, and the total free amino acid content in the electric thermostatic roasting for the 1–17 min, 300 °C (EHAR3) group (347.05 mg/100 g) was significantly higher than that in the other experimental groups (p < 0.05). By using Spearman correlation analysis, the roasting loss rate showed a highly significant negative correlation with essential amino acids (EAAs), non-essential amino acids (NEAAs), and total free amino acids (TAAs) (the correlation coefficients (r) were 0.82, 0.87, and 0.87, respectively) with p < 0.01. There was no correlation between changes in the free amino acid content and fatty acid content (p > 0.05). By using Differential scanning calorimetry (DSC) analysis, we also found that there was no significant difference in peak temperature (Tp) between the VTR3 and EHAR experimental groups (p > 0.05). Variable temperature electric heating can affect the flavor of lamb, and there are significant differences in the content of flavor precursors such as fatty acids and amino acids in Xinjiang tannur-roasted mutton.
Impact of Thermal Processing on the Structure, Antioxidant Properties and Hypoglycemic Activities of Sweet Potato Polysaccharides
Authors: Liu Chuan , Miao Yu , Zhou Wenjia , Ma Yiming , Guo Wenkui , Li Aili
Published: September 2024

In this study, three kinds of thermal treatments were applied to sweet potatoes: steaming (100 °C, 20 min), frying (150 °C, 10 min), and baking (200 °C, 30 min). We analyzed the changes in the physicochemical structure, antioxidant properties, and hypoglycemic activities of sweet potato polysaccharides between untreated and heat-treated samples. The results showed that the polysaccharides of all sweet potatoes (untreated and heat-treated) were composed of pyranose structures, had low protein content, and shared the same monosaccharide composition. Infrared spectra showed that the three thermal processing treatments had no significant effect on the functional groups or chemical bonding of sweet potato polysaccharides. In addition, all four polysaccharides exhibited dose-dependent antioxidant and hypoglycemic activities. The above experimental results suggest that thermal processing did not affect the physicochemical, antioxidant, or hypoglycemic activities of sweet potato polysaccharides.
Production of α-Glycerylphosphorylcholine in Fermented Roots, Tubers, and Fruits
Authors: Tse Timothy J. , Chicilo Farley , Wiens Daniel J. , Shen Jianheng , Anleu Alegria Javier , Kim Young Jun , Hong Ji Youn , Kim Jae Kyeom , Shin Eui-Cheol , Reaney Martin J. T. , Shim Youn Young
Published: September 2024

Vegetables and fruits, high in starch and sugars, are promising substrates for bioethanol production, but can also yield valuable nootropic compounds, such as α-glycerylphosphorylcholine (α-GPC). This compound is a known cognitive enhancer that works by increasing the release of acetylcholine, a neurotransmitter essential for learning and memory. In this study, select root and tuber crops, as well as fruits, were subjected to Saccharomyces cerevisiae fermentation to observe the co-production of ethanol and α-GPC. The ethanol yields from these substrates were comparable to those from wheat (var. AC Andrew), ranging from 30.44 g/L (beet) to 70.04 g/L (lotus root). Aside from ethanol, α-GPC was also produced, with purple top turnip yielding 0.91 g/L, the second highest concentration after wheat (used as a reference), which produced 1.25 g/L. Although α-GPC yields in the tested substrates were lower than those from cereal grains (e.g., wheat and barley), a noteworthy observation was the production of methanol in many of these substrates. Methanol was detected in all feedstocks except wheat, with concentrations ranging from 0.10 g/L (cassava) to 1.69 g/L (purple top turnip). A linear regression analysis revealed a strong correlation between methanol and α-GPC content (R2 = 0.876; slope = 0.52), suggesting a potential link in their biosynthetic pathways. These feedstocks not only proved effective as substrates for bioethanol production, but also showed potential for generating value-added compounds such as α-GPC. This dual-purpose potential presents new market opportunities for producers by leveraging both biofuel and nootropic compound production. Furthermore, the observed relationship between methanol and α-GPC production warrants further investigation to elucidate the metabolic pathways involved.
Microcapsule Preparation and Properties of Flavonoid Extract from Immature Citrus reticulata ‘Chachiensis’ Peel
Authors: Zhang Xinyi , Li Qili , Wu Sisi , Liu Yan , Chen Jiaxu , Li Tao , Su Donglin
Published: September 2024

Citrus reticulata ‘Chachiensis’ is a citrus cultivar in the Rutaceae family, and its peel is commonly utilized as a raw material for Guangchenpi. This study used flavonoid extract from the peel of immature Citrus reticulata ‘Chachiensis’ (CCE) as the raw material to investigate the encapsulation ability of different wall materials (plant-based proteins, including soybean protein isolation (SPI), pea protein (PP), and zein; carbohydrates, including maltodextrin (MD), Momordica charantia polysaccharide (MCP), and gum acacia (GA); and composite wall materials of both types) on CCE. The wall material with the highest encapsulation rate was selected for the preparation of CCE microcapsules. Furthermore, the physicochemical characteristics, antioxidant capacity, bioavailability, and storage stability of the CCE microcapsules were explored. The results indicated that among all wall materials, the composite wall material PPMD had the highest encapsulation rate, which was 84.44 ± 0.34%. After encapsulation, the microcapsules tended to have a yellow color and exhibited characteristics such as system stability, low moisture content, and low hygroscopicity. In vitro antioxidant assays revealed that the encapsulation of CCE significantly increased the scavenging rates of DPPH and ABTS free radicals. In vitro gastrointestinal digestion experiments indicated that the release rate of PPMD-CCE in intestinal fluid was significantly greater than that of free CCE, ultimately reaching 85.89 ± 1.53%. Storage experiments demonstrated that after 45 days under various temperature and light conditions, the retention rate of CCE in the microcapsules was significantly greater than that of free CCE. The above findings provide new possibilities for the application of PP and plant proteins and lay a foundation for the future industrial application of CCE.
Sampling Theorems Associated with Offset Linear Canonical Transform by Polar Coordinates
Authors: Zhao Hui , Li Bing-Zhao
Published: September 2024

The sampling theorem for the offset linear canonical transform (OLCT) of bandlimited functions in polar coordinates is an important signal analysis tool in many fields of signal processing and optics. This paper investigates two sampling theorems for interpolating bandlimited and highest frequency bandlimited functions in the OLCT and offset linear canonical Hankel transform (OLCHT) domains by polar coordinates. Based on the classical Stark’s interpolation formulas, we derive the sampling theorems for bandlimited functions in the OLCT and OLCHT domains, respectively. The first interpolation formula is concise and applicable. Due to the consistency of the OLCHT order, the second interpolation formula is superior to the first interpolation formula in computational complexity.
Adverse Cardiovascular Outcomes in Young Cannabis Users: A Nationwide Analysis
Authors: Joseph Varughese Vivek , Mathai Yoshua , Joseph Cara , Carlyle Logan
Published: September 2024

Background: With the growing trends in recreational marijuana use, our study aims at analyzing the association between acute coronary syndromes (ACS) and ventricular fibrillation (Vfib) and cannabis use disorder in young adults (18–45). Methods: Young adult hospitalizations (18–45 years) with documented ACS/ventricular fibrillation and documented cannabis use were identified from the National Inpatient Sample (2019). Primary outcomes included prevalence and odds of ACS/ventricular fibrillation with cannabis use disorder. Patient factors that held significant association with adverse cardiovascular events in young cannabis users were studied. Propensity scoring and neighbor matching were used to compare resource utilization and in-hospital outcomes in the study population. Results: Among young patients (18–45) admitted for ACS, documented cannabis use disorder (CUD) had a statistically significant association with an odds ratio of 2.29 (2.48–3.04) after adjusting for age, sex, race, household income, smoking, cocaine use, uncontrolled hypertension, diabetes and hyperlipidemia. Documented CUD had a significant association with ventricular fibrillation in the population with an odds ratio of 2.29 (1.51–3.49) after adjusting for the above-mentioned factors. Among admissions with documented CUD, patient factors that held significant association with admitting diagnosis of ACS/Vfib were: black race (OR: 1.73), uncontrolled hypertension (OR: 4.08) and diabetes (OR: 2.45). Propensity-matched cohorts with documented CUD and ACS had significantly higher mean length of hospital stay 3.28 (2.98–3.53) days when compared to the cohort without documented CUD, 2.69 (2.32–2.82) days. The mean of total hospital charges was higher in the cohort with documented CUD at $92,390.64 (92,240.31–92,445.76) compared to $90,886.44 (89,932.21–91,042.56) in the cohort without cannabis use disorder. Conclusions: Documented diagnosis of cannabis use disorder had statistically significant association with admission diagnosis of ACS/Vfib even after accounting for confounders. A documented race as black and co-existing diagnosis of uncontrolled hypertension and diabetes had a significant association with admission diagnosis of ACS in the population with documented cannabis use disorder. Propensity-matched cohorts with cannabis use disorder with the main admitting diagnosis of ACS/Vfib were associated with a higher mean length of hospital stay and a higher mean of total charges compared to the matched cohorts without documented cannabis use disorder.
Determination of Environmental Flow Using a Holistic Methodology in Three River Paths in the Tempisque River Basin, Costa Rica
Authors: Chavarría-Pizarro Laura , Watson-Hernández Fernando , Quesada-Alvarado Francisco , Serrano-Núñez Valeria , Bustos-Vásquez Ana Lucía , Fernández-Chévez Karina , Chacón-Gutierrez Jendry , Guzmán-Arias Isabel
Published: September 2024

The study of environmental flow has garnered significant scientific interest due to the considerable degradation caused by human activities on aquatic ecosystem dynamics. Environmental flow is defined as the quantity, timing, and quality of water flow required to sustain freshwater and estuarine ecosystems while meeting human demands. Research in riverine ecosystems can generate the critical scientific knowledge needed to determine an adequate environmental flow that balances the requirements of both aquatic organisms and human populations. This study is part of a series of investigations aimed at field-testing different methodologies to determine appropriate environmental flow levels for rivers with specific characteristics. In particular, we adapted and validated a holistic methodology for calculating the environmental flow regime in the Tempisque River basin in Costa Rica. This research involved analyzing hydrological parameters, hydraulic conditions, the presence of flow bioindicators, and various anthropogenic uses of the river (such as human consumption, productive, recreational, and cultural activities) to estimate environmental flow requirements throughout the year. The findings indicate that the lower and upper limits of the environmental flow for the studied section of the Tempisque River correspond to the monthly excesses of 95.00% and 64.00%, respectively. These results provide a reliable annual flow regime that can inform decision-making by authorities in water resource management, particularly in regions where there is a high demand for water across different human activities.
Cutoff Values of Aldosterone and the Aldosterone–Renin Ratio for Predicting Primary Aldosteronism in Patients with Resistant Hypertension: A Real-Life Study
Authors: da Silveira João Vicente , Sangaleti Carine , Camacho Cleber , Maciel Ana Alice Wolf , Irigoyen Maria Claudia , Macedo Thiago , De Lima José Jayme G. , Drager Luciano F. , Bortolotto Luiz Aparecido , Lopes Heno Ferreira , Almeida Madson Q. , Egan Brent M. , Consolim-Colombo Fernanda Marciano
Published: September 2024

Primary aldosteronism (PA) is commonly associated with resistant hypertension. Biochemical tests can be clinically useful in the screening and diagnosis of primary aldosteronism. This study aimed to identify the cutoff values of aldosterone levels (A) and the aldosterone–renin ratio (ARR) for an accurate prediction of PA in patients with apparent resistant hypertension in a real-life scenario. This database-based study included a historical cohort of male and female patients with apparent resistant hypertension, aged 18 years or older and surveyed for PA in a specialized center from 2008 to 2018. Aldosterone and plasma renin activity (PRA) or the plasma renin concentration (PRC) were measured in the treated hypertensive patients. The patients with positive screening results were subsequently referred to the endocrinology department for confirmatory tests. The patients with confirmed PA were included in the case group, and the others remained as controls. Receiver-operating characteristic (ROC) curves were used to identify the cutoff points for aldosterone and the ARR, thereby analyzing their sensitivity and specificity for confirmed PA. Among the 3464 patients (59 ± 13 years old, 41% male) who had apparent resistance hypertension screened, PA was confirmed in 276 individuals (8%). A ≥ 16.95 ng/dL (95% CI: 0.908–0.933) had an odds ratio of 6.24 for PA, while A/PRA ≥ 29.88 (95% CI: 0.942–0.984) or an A/PRC ≥ 2.44 (95% CI: 0.978–0.990) had an odds ratio of 216.17 for PA diagnoses. Our findings suggest that a positive PA screening with aldosterone ≥ 17 ng/dL associated with A/PRA ≥ 29.88 or an A/PRC ratio of ≥2.44 should be sufficient to confirm the diagnosis of PA without confirmatory testing.
Evolution of Ostomy Pouch Design: Opportunities for Composite Technologies to Advance Patient Care
Authors: Gilpin Victoria , Magee Niamh , Scott Cameron , Pourshahidi L. Kirsty , Gill Chris I. R. , Simpson Ellen E. A. , McCreadie Karl , Davis James
Published: September 2024

Stoma surgery can be critical in helping to restore the well-being of patients suffering from gastrointestinal disease or injury but it inevitably comes with numerous psychological and physiological complications. Disposable pouch systems which enable the collection of bowel waste have revolutionized stoma care but providing robust, discreet devices that can efficiently meet the requirements of the patient can be challenging. Pouches must securely store a microbially active waste whilst preventing leakage, protecting the underlying skin from inflammation and minimizing odor. All of this needs to be achieved within the design constraints of a pouch that is easy to manage and yet still maintains a discreet body contour. Stoma collection has moved from the waste being collected in butyl rubber pouches to much more elaborate systems incorporating assemblies of polyvinylidene chloride, ethylene vinyl acetate, ethyl vinyl alcohol and polyvinyl alcohol with new, skin-friendly adhesive such as hydrocolloid and silicones impregnated with ceramides and aloe. Moreover, 3D printing has emerged as a means of providing personalized stoma pouches that can potentially address the age-old issue of leakage. Despite such advances, stoma pouches have evolved slowly over the past 70 or so years. A survey of the literature reveals an abundance of quality-of-life studies but a dearth of reports addressing the key technological challenges. Consequently, this narrative review considers current stoma pouch technology and highlights the issues that continue to afflict stoma patients. Research and patent literature is critically appraised in terms of current pouch technology and the potential opportunities for new composite materials are identified.
Comparison of Measurements for Recording Postural Control in Standing and Seated Position in Healthy Individuals
Authors: Floessel Philipp , Hammerschmidt Franziska , Koltermann Jan Jens , Foerster Justin , Beck Heidrun , Disch Alexander Carl , Datzmann Thomas
Published: September 2024

Background: A standard method of assessing postural control is to measure while standing. However, its implementation is usually limited. Recording postural control directly on the trunk in a seated position could provide an alternative diagnostic method for quantifying neuromuscular control. Methods: A comparison of center of pressure (CoP) measurements in the standing and sitting positions was performed on 66 healthy adult subjects. The reliability of the measurements in the sitting position was tested in 23 subjects. In addition, the extension force of all test subjects was recorded. Results: The assessments of CoP fluctuations in standing and seated positions showed adequate agreement (deviation 9.1%). Furthermore, good internal consistencies with a sufficient test–retest reliability could be demonstrated for the measurements in seated position. Both CoP measurement methods showed a comparable Spearman correlation to obtained extension force measurements (standing: 0.24, seated: 0.23). Conclusions: Our results show that recording CoP fluctuations in the sitting position is a reliable and valid adjunct to single-leg stance measurements. It could serve as an additional alternative to quantify neuromuscular control in impaired patients who cannot adequately perform the single-leg stance. In addition, measurement in the seated position allows direct recording of neuromuscular control at the trunk.
Photobiomodulation as Medicine: Low-Level Laser Therapy (LLLT) for Acute Tissue Injury or Sport Performance Recovery
Authors: Lawrence Julia , Sorra Karin
Published: September 2024

Background/Objectives: Low-level laser therapy (LLLT) has gained traction in sports and exercise medicine as a non-invasive therapeutic for preconditioning the body, exertion recovery, repair and injury rehabilitation. LLLT is hypothesized to modulate cellular metabolism, tissue microenvironment(s) and to decrease inflammation while posing few adverse risks. This review critically examines the evidence-base for LLLT effectiveness focusing on immediate care settings and acute/subacute applications (<6 months post-injury). Methods: A comprehensive literature search was conducted, prioritizing systematic reviews, meta-analyses and their primary research papers. Results: Findings are relevant to trainers and athletes as they manage a wide range of issues from superficial abrasions to deeper tissue concerns. LLLT parameters in the research literature include wide ranges. For body surface structures, studies show that LLLT holds promise in accelerating wound healing. In sport performance studies, LLLT is typically delivered pre-exercise and reveals beneficial effects on exertion recovery, improvements in muscle strength, endurance and reduced fatigue. Evidence is less convincing for acute, deep tissue injury models, where most studies do not report significant benefits for functional outcomes over conventional therapeutic modalities. Conclusions: Variability in LLLT delivery parameters and findings across studies underscores a need for clear treatment guidelines for the profession. Technical properties of laser light delivery to the body also differ materially from LED devices. Sport physiotherapists, team physicians, trainers and athletes should understand limitations in the current evidence-base informing photobiomodulation use in high-performance sport settings and weigh potential benefits versus shortcomings of LLLT use in the mentioned therapeutic contexts.
The Role of Plain Radiography in Assessing Aborted Foetal Musculoskeletal Anomalies in Everyday Practice
Authors: Rossini Benedetta , Carnevale Aldo , Parenti Gian Carlo , Zago Silvia , Sigolo Guendalina , Feletti Francesco
Published: September 2024

Conventional radiography is widely used for postmortem foetal imaging, but its role in diagnosing congenital anomalies is debated. This study aimed to assess the effectiveness of X-rays in detecting skeletal abnormalities and guiding genetic analysis and counselling. This is a retrospective analysis of all post-abortion diagnostic imaging studies conducted at a centre serving a population of over 300,000 inhabitants from 2008 to 2023. The data were analysed using descriptive statistics. X-rays of 81 aborted foetuses (total of 308 projections; mean: 3.8 projections/examination; SD: 1.79) were included. We detected 137 skeletal anomalies. In seven cases (12.7%), skeletal anomalies identified through radiology were missed by prenatal sonography. The autopsy confirmed radiological data in all cases except for two radiological false positives. Additionally, radiology failed to identify a case of syndactyly, which was revealed by anatomopathology. X-ray is crucial for accurately classifying skeletal abnormalities, determining the causes of spontaneous abortion, and guiding the request for genetic counselling. Formal training for both technicians and radiologists, as well as multidisciplinary teamwork, is necessary to perform X-ray examinations on aborted foetuses and interpret the results effectively.
The Influence of Intelligent Guided Vehicle Configuration on Equipment Scheduling in the Railway Yards of Automated Container Terminals
Authors: Chen Hongbin , Liu Wei
Published: September 2024

The efficiency of collecting and distributing goods has been improved by establishing railway lines that serve new automated container terminals (ACTs) and by constructing central railway stations close to ports. To aid in this process, intelligent guided vehicles (IGVs), which are renowned for their flexibility and for the convenience with which one can adjust their number and speed, have been developed to be used as horizontal transport vehicles that can transport goods between the railway yard and the front of the port. However, they also introduce some difficulties and complexities that affect terminal scheduling. Therefore, we took the automated rail-mounted container gantry crane (ARMG) scheduling problem as our main research object in this study. We established a mixed-integer linear programming (MILP) model to minimize the makespan of ARMGs, designed an adaptive large neighborhood search (ALNS) algorithm, and explored the influence of IGV configuration on ARMG scheduling through a series of experiments applied to a series of large-scale numerical examples. The experimental results show that increasing the number of IGVs can improve the operational efficiency of railway yards, but this strategy reduces the overall time taken for the ARMG to complete various tasks. Increasing or decreasing the speed of the IGVs within a given range has a clear effect on the problem at hand, while increasing the IGV travel speed can effectively reduce the time required for the ARMG to complete various tasks. Operators must properly adjust the IGV speed to meet the requirements of the planned operation.
Public Service Media and Platformization: What Role Does EU Regulation Play?
Authors: Dragomir Marius , Rodríguez Castro Marta , Aslama Horowitz Minna
Published: September 2024

Conceived as institutions funded by the public purse and intended to exist devoid of political influence, the mandate of public service media (PSM) entities is to disseminate reliable news content and high-quality audiovisual productions to all demographic segments, inclusive of marginalized communities and audiences that are typically under-served. Over the previous ten years, the rise in prominence of global platforms in national media systems has precipitated many changes in the media sector, including unique challenges for PSM institutions guided by specific public service values. Using a holistic conceptual framework for assessing the implementation of these values, this article analyzes the impact of platformization on Europe’s PSM and discusses how the Union’s policy approaches affect related challenges to PSM. The analysis indicates that while the European Union (EU) has accorded a high priority to PSM within its media policy framework, the role that Brussels plays in protecting the independence and efficacy of PSM has been circumscribed, given that the onus of regulating PSM entities rests with national governments. This has engendered contrasting experiences wherein certain PSM outlets enjoy political independence and command significant public trust while others function as state-controlled propaganda vehicles, advancing the objectives and interests of governing bodies. The EU has addressed global platform power in recent attempts to safeguard its digital future, including the Digital Services Act (DSA), Digital Markets Act (DMA), and the European Media Freedom Act (EMFA). However, these acts do not adequately address PSM’s two central and often interconnected problems: funding challenges and political pressures.
Financial Distress Prediction in the Nordics: Early Warnings from Machine Learning Models
Authors: Abrahamsen Nils-Gunnar Birkeland , Nylén-Forthun Emil , Møller Mats , de Lange Petter Eilif , Risstad Morten
Published: September 2024

This paper proposes an explicable early warning machine learning model for predicting financial distress, which generalizes across listed Nordic corporations. We develop a novel dataset, covering the period from Q1 2001 to Q2 2022, in which we combine idiosyncratic quarterly financial statement data, information from financial markets, and indicators of macroeconomic trends. The preferred LightGBM model, whose features are selected by applying explainable artificial intelligence, outperforms the benchmark models by a notable margin across evaluation metrics. We find that features related to liquidity, solvency, and size are highly important indicators of financial health and thus crucial variables for forecasting financial distress. Furthermore, we show that explicitly accounting for seasonality, in combination with entity, market, and macro information, improves model performance.
Novel Food-Based Enrichment Increases Captive Cownose Stingray (Rhinoptera bonasus) Engagement with Enrichment Item
Authors: Harris Mia C. Y. , Frazier Heidi , Mayall Sean , Frey Alexandra D. , Boyle Sarah A.
Published: September 2024

Environmental enrichment can provide captive animals with stimuli that increase physical and mental activity. We investigated the extent to which a novel enrichment item, defined as enrichment that individuals have never experienced prior to the study, engages captive cownose stingrays (Rhinoptera bonasus). We hypothesized that stingray interactions with the enrichment item are associated with the novelty of the enrichment item (i.e., time since presentation of the enrichment item, number of weeks exposed to the enrichment), the presence of food, and the number of human visitors at the stingray exhibit. The novelty of the enrichment item and the presence of food were most strongly associated with stingray interactions with the enrichment item. Although stingrays engaged with the enrichment throughout a 5-week period, interactions decreased as the amount of time the enrichment item remained in the water increased during a 60 min period and interactions decreased as the weeks progressed. Furthermore, stingrays had increased interactions when food was present inside the enrichment item. The number of human visitors had a weaker association with stingray interactions with the enrichment item, but during the food-based trials, there were increased interactions with the enrichment when more visitors were present. Our findings suggest that variation in enrichment routines (to maintain novelty) and variation in an enrichment item’s use of food may help continue engagement with enrichment items.
Research–Teaching Nexus in Electronic Instrumentation, a Tool to Improve Learning and Knowledge of Marine Sciences and Technologies
Authors: del-Río Fernández Joaquín , Toma Daniel-Mihai , Carandell-Widmer Matias , Martinez-Padró Enoc , Nogueras-Cervera Marc , Bou Pablo , Mànuel-Làzaro Antoni
Published: September 2024

In higher education institutions, there is a strong interaction between research and teaching activities. This paper presents a case study on the research–teaching nexus based on an analysis of academic results related to the course “Instrumentation and Data Analyses in Marine Sciences” within the Marine Sciences and Technologies Bachelor’s Degree at the Universitat Politècnica de Catalunya (UPC), taught at the Vilanova i la Geltrú campus (Barcelona, Spain). The start of this degree in the academic year 2018–2019 allowed the assignment of technological subjects in the degree to a research group with extensive experience in the research and development of marine technologies. The first section of this paper aims to provide a justification for establishing the Marine Sciences and Technologies Bachelor’s Degree. It highlights the necessity of this program and delves into the suitability of the profiles of the professors responsible for teaching marine technology subjects. Their entrepreneurial research trajectory and their competence in electronic instrumentation are strong arguments for their appropriateness. The next section of the paper explores a detailed analysis of academic results based on surveys and student performance indices. Through a thorough examination of these data, this case study demonstrates, within the context of all UPC degrees, that assigning a research group made up of experienced professors and researchers in the field who are accustomed to working as a team produces superior academic results compared to assignments to professors who do not work as a team. Teamwork presents specific skills necessary for operating the infrastructures and equipment associated with an experimental degree.
Some Observations on the Cantonese Lexical Suprafixes
Authors: de Sousa Hilário
Published: September 2024

Suprafixation (more specifically, tonal affixation) is a word-building strategy that is somewhat frequently employed in Cantonese. This article explores the development of the lexical suprafixes in Standard Cantonese from three perspectives: (a) earlier descriptions of the Cantonese suprafixes and the behaviour of the lexical suprafixes in some older Romanised Cantonese texts; (b) the behaviour of the lexical suprafixes in some non-standard Cantonese varieties; and (c) the behaviour of the suprafixes and diminutives in Yuè and Pínghuà dialects in general. A definite answer cannot be found to the question of what the origin of the Cantonese suprafixes is. Nonetheless, the theory that the Cantonese lexical suprafixes stem from the diminutive suffix *ɲi 兒 (Cantonese ji4, Mandarin ér) remains the most convincing.
Progress of Multidimensional Nano-Additives under Dry/Liquid Wear: A Review
Authors: Xiao Na , Wu Chao , Yang Kang , Tang Jun
Published: September 2024

An investigation of the interaction between multidimensional nano-additives and tribofilms is crucial for enhancing mechanical efficiency, extending equipment lifespan, and reducing environmental impacts. Improved tribofilm performance is obtained via several mechanisms: filling surface defects with 0D nano-additives, directional lubrication for 1D nano-additives, interlayer slippage for 2D nano-additives, and improved film durability for 3D nano-additives. Under dry lubrication, the formation of tribofilms via mechanical mixing is influenced by material hardness, surface roughness, and frictional conditions, with their thicknesses increasing by 20–30% under high loading. Conversely, liquid-lubricated films result from the physical adsorption and chemical reactions of the lubricants, with extremely high pressure additives reducing the friction coefficient by 30–50% at high pressure. A greater understanding of these mechanisms is beneficial for optimizing industrial technologies and developing efficient, eco-friendly lubrication systems.
A Fixed-Time Event-Triggered Consensus of a Class of Multi-Agent Systems with Disturbed and Non-Linear Dynamics
Authors: Wang Yueqing , Wang Te , Li Zhi
Published: September 2024

This paper investigates the problem of fixed-time event-triggered consensus control for a class of multi-agent systems with disturbed and non-linear dynamics. A fixed-time consensus protocol based on an event-triggered strategy is proposed, which can ensure a fixed-time event-triggered consensus, reduce energy consumption, and decrease the frequency of controller updates. The control protocol can also be applied to the case when the systems are free of disturbances; it solves the problem of high convergence time of the systems and reduces energy consumption of the systems. Sufficient conditions are proposed for the multi-agent systems with disturbed and non-linear dynamics to achieve the fixed-time event-triggered consensus by using algebraic graph theory, inequalities, fixed-time stability theory, and Lyapunov stability theory. Finally, simulation results show that the proposed control protocol has the advantages of both event-triggered and fixed-time convergence; compared to previous work, the convergence time of the new control protocol is greatly reduced (about 1.5 s) and the update times are also greatly reduced (less than 50 times), which is consistent with the theoretical results.
Inverse Probability-Weighted Estimation for Dynamic Structural Equation Model with Missing Data
Authors: Cheng Hao
Published: September 2024

In various applications, observed variables are missing some information that was intended to be collected. The estimations of both loading and path coefficients could be biased when ignoring the missing data. Inverse probability weighting (IPW) is one of the well-known methods helping to reduce bias in regressions, while belonging to a promising but new category in structural equation models. The paper proposes both parametric and nonparametric IPW estimation methods for dynamic structural equation models, in which both loading and path coefficients are developed into functions of a random variable and of the quantile level. To improve the computational efficiency, modified parametric IPW and modified nonparametric IPW are developed through reducing inverse probability computations but making fuller use of completely observed information. All the above IPW estimation methods are compared to existing complete case analysis through simulation investigations. Finally, the paper illustrates the proposed model and estimation methods by an empirical study on digital new-quality productivity.
When to Intervene in Acute Necrotizing Pancreatitis: A Narrative Review of the Optimal Timing for Intervention Strategies
Authors: Paramythiotis Daniel , Karlafti Eleni , Tsavdaris Dimitrios , Giakoustidis Alexandros , Panidis Stavros , Ioannidis Aristeidis , Prassopoulos Panos , Michalopoulos Antonios
Published: September 2024

Introduction: Acute necrotizing pancreatitis (ANP) is the acute inflammation of pancreatic parenchyma, most commonly due to alcohol abuse or cholelithiasis. The treatment can be either conservative or invasive, including a variety of techniques; however, it has not yet been established if the intervention should be early or if it should be delayed. The aim of this review is to investigate the optimal time for intervention in ANP. Methods: A literature search was conducted in PubMed and Scopus from inception until September 2024 for studies reporting the comparison between early and late intervention. Results: Early intervention, within 4 weeks of symptom onset, often involves drainage via percutaneous, endoscopic, or combined methods. Delayed intervention occurs after 4 weeks of symptom onset. This can be conducted either surgically or via minimally invasive means. The results of this review reveal that the time of intervention for ANP plays an important role in the prognosis and the course of the disease. In particular, early intervention is associated with higher mortality, which is also the primary clinical outcome. Delayed intervention is also superior regarding secondary clinical outcomes, specifically the complications associated with the intervention. Thus, it is accompanied by fewer episodes of new-onset organ failure, bleeding, gastrointestinal fistula, pancreatic fistula, wound infection, endocrine pancreatic insufficiency, and other complications. Finally, delayed intervention results in shorter stays, both in hospitals and the ICU. Conclusions: Delayed intervention is clearly more effective than early intervention and should be preferred. However, early intervention appears to be both safe and effective, and it is feasible.
Interleukin-6 Receptor Gene rs1800795 Polymorphism and Expression of Interleukin-6 in Gingival Tissue in Patients with Periodontitis
Authors: Mazurek-Mochol Małgorzata , Bonsmann Tobias , Malinowski Damian , Serwin Karol , Czerewaty Michał , Safranow Krzysztof , Pawlik Andrzej
Published: September 2024

Periodontitis is a multifactorial inflammatory disease. This chronic periodontal disease is caused by a bacterial infection in the gums, which triggers a host inflammatory response. To eliminate the bacterial infection, immune response mechanisms are activated, leading to inflammation and damage to the periodontal tissues. This process involves many cytokines, including IL-6, a cytokine with antibacterial properties. An ongoing bacterial infection in the periodontal tissues leads to its excessive production, which increases inflammation. In this study, we examined IL-6 receptor gene rs1800795 polymorphism in patients with periodontitis in comparison with healthy subjects, as well as the correlation between rs1800795 genotypes and clinical parameters. Additionally we examined the expression of IL-6 in gingival tissue in patients with periodontitis and control subjects, as well as the correlation between gingival expression of IL-6 and clinical parameters. This study included 200 patients with periodontitis and 158 healthy subjects as the control group. Biopsy specimens of gingival tissue in which IL-6 expression was detected were taken from 14 patients with periodontitis and 8 controls who had undergone minor surgery. There were no statistically significant differences in the distribution of IL-6 rs1800795 genotypes and alleles between patients with periodontitis and control subjects. There were also no statistically significant correlations between IL-6 rs1800795 genotypes and clinical parameters in patients with periodontitis. There were no differences in IL-6 expression in the gingival tissue between patients with periodontitis and controls. There was also no correlation between IL-6 expression in the gingival tissue of patients with periodontitis and clinical parameters. In the control group, IL-6 expression in gingival tissue correlated negatively with the approximal plaque index, which reflects the size of bacterial plaques. The results of our study suggest a protective role for IL-6 against bacterial growth in the periodontal tissue. However, it should be noted that several parameters directly or indirectly affect the accumulation of bacterial plaque.
Probio-Ichnos: A Database of Microorganisms with In Vitro Probiotic Properties
Authors: Tsifintaris Margaritis , Kiousi Despoina Eugenia , Repanas Panagiotis , Kamarinou Christina S. , Kavakiotis Ioannis , Galanis Alex
Published: September 2024

Probiotics are live microorganisms that, when consumed in adequate amounts, exert health benefits on the host by regulating intestinal and extraintestinal homeostasis. Common probiotic microorganisms include lactic acid bacteria (LAB), yeasts, and Bacillus species. Here, we present Probio-ichnos, the first manually curated, literature-based database that collects and comprehensively presents information on the microbial strains exhibiting in vitro probiotic characteristics (i.e., resistance to acid and bile, attachment to host epithelia, as well as antimicrobial, immunomodulatory, antiproliferative, and antioxidant activity), derived from human, animal or plant microbiota, fermented dairy or non-dairy food products, and environmental sources. Employing a rigorous methodology, we conducted a systematic search of the PubMed database utilizing the keyword ‘probiotic’ within the abstracts or titles, resulting in a total of 27,715 studies. Upon further manual filtering, 2207 studies presenting in vitro experiments and elucidating strain-specific probiotic attributes were collected and used for data extraction. The Probio-ichnos database consists of 12,993 entries on the in vitro probiotic characteristics of 11,202 distinct strains belonging to 470 species and 143 genera. Data are presented using a binary categorization approach for the presence of probiotic attributes according to the authors’ conclusions. Additionally, information about the availability of the whole-genome sequence (WGS) of strains is included in the database. Overall, the Probio-ichnos database aims to streamline the navigation of the available literature to facilitate targeted validation and comparative investigation of the probiotic properties of the microbial strains.
Combinatorial Effects of Ursodeoxycholic Acid and Antibiotic in Combating Staphylococcus aureus Biofilm: The Roles of ROS and Virulence Factors
Authors: Tyagi Anuradha , Kumar Vinay , Joshi Navneet , Dhingra Harish Kumar
Published: September 2024

Staphylococcus aureus is a biofilm-forming bacterium responsible for various human infections, one particularly challenging to treat due to its antibiotic resistance. Biofilms can form on both soft tissues and medical devices, leading to persistent and hard-to-treat infections. Combining multiple antimicrobials is a potential approach to overcoming this resistance. This study explored the effects of ursodeoxycholic acid (UDCA) combined with the antibiotic ciprofloxacin against S. aureus biofilms, aiming to evaluate any synergistic effects. Results showed that UDCA and ciprofloxacin co-treatment significantly reduced biofilm formation and disrupted pre-formed biofilms more effectively than either agent alone (p < 0.01). The combination also displayed a slight synergistic effect, with a fractional inhibitory concentration of 0.65. Additionally, the treatment reduced the production of extracellular polymeric substances, increased reactive oxygen species production, decreased metabolic activity, altered cell membrane permeability, and lowered cell surface hydrophobicity in S. aureus. Furthermore, it diminished biofilm-associated pathogenic factors, including proteolytic activity and staphyloxanthin production. Overall, the UDCA–ciprofloxacin combination shows considerable promise as a strategy to combat infections related to staphylococcal biofilms, offering a potential solution to the healthcare challenges posed by antibiotic-resistant S. aureus.
Dissecting the Simultaneous Extracellular/Intracellular Contributions to Cr(VI) Reduction under Aerobic and Anaerobic Conditions Using the Newly Isolating Cr(VI)-Reducing Bacterium of Pseudomonas sp. HGB10
Authors: Chen Shenglei , Wang Xiaoyu , Zhao Qinyi , Xu Qiao , Zhang Yini
Published: September 2024

Quantifying extracellular and intracellular contributions to Cr(VI) reduction is crucial for understanding bacterial Cr(VI)-reduction mechanisms. However, this contribution under different oxygen conditions remains largely unexplored. This study quantified the extracellular/intracellular contribution to aerobic and anaerobic Cr(VI) reduction using Pseudomonas sp. HGB10, an isolated Cr(VI)-reducing bacterium, as the experimental model. Interestingly, it was found that the lower anaerobic minimum inhibitory concentration (MIC) does not necessarily imply a lower anaerobic Cr(VI)-reduction rate for HGB10. For the initial Cr(VI) concentration of 20 mg L−1, the maximum anaerobic Cr(VI)-reducing rate reached 100%, while the aerobic counterpart was only 75%, even though the value of the aerobic MIC (400 mg L−1) is twice that of the anaerobic (200 mg L−1). Additionally, the calculated extracellular contributions to aerobic and anaerobic Cr(VI) reduction were 10.76% and 55.71%, respectively, while the intracellular contributions were 68.29% and 40.38%. The sum of extracellular and intracellular contributions to Cr(VI) reduction (79.05% and 96.09%) under aerobic and anaerobic conditions was nearly balanced with the corresponding maximum values despite minor relative errors. These results indicated that anaerobic Cr(VI) reduction mainly occurred extracellularly rather than intracellularly, which differs from the existing result. Overall, our findings provide new insights into bacterial Cr(VI) reduction.
A Systematic Review of Sporadic Creutzfeldt-Jakob Disease: Pathogenesis, Diagnosis, and Therapeutic Attempts
Authors: Jurcau Maria Carolina , Jurcau Anamaria , Diaconu Razvan Gabriel , Hogea Vlad Octavian , Nunkoo Vharoon Sharma
Published: September 2024

Creutzfeldt-Jakob disease is a rare neurodegenerative and invariably fatal disease with a fulminant course once the first clinical symptoms emerge. Its incidence appears to be rising, although the increasing figures may be related to the improved diagnostic tools. Due to the highly variable clinical picture at onset, many specialty physicians should be aware of this disease and refer the patient to a neurologist for complete evaluation. The diagnostic criteria have been changed based on the considerable progress made in research on the pathogenesis and on the identification of reliable biomarkers. Moreover, accumulated knowledge on pathogenesis led to the identification of a series of possible therapeutic targets, although, given the low incidence and very rapid course, the evaluation of safety and efficacy of these therapeutic strategies is challenging.