bluuebunny/crossref_metadata_2025 huggingface dataset:
ANALISA KEBUTUHAN MATERIAL DAN RANTAI PADA PROSES PRODUKSI MESIN TEKUK PLAT HIDROLIK
Authors: Eka Putra Ismet , Wardianto Dedi , Juliantoni Juliantoni
Published: December 2024

Mesin penekuk plat atau yang disebut mesin bending, adalah pengerjaan membentuk logam lembaran (plat) sehingga sesuai dengan bentuk dan ukuran yang sudah direncanakan. Penelitian ini menerapkan teknologi hidrolik pada proses pembentukan dan penekukan plat. Mesin bending ini menerapkan mekanisme penjepitan pada plat dan melakukan pembebanan dengan menggunakan tenaga hidrolik untuk menekuk plat. Dalam pembuatan mesin bending ini perlu di analisisa apa saja kebutuhan material dan rantai proses produksi dari mesin penekuk plat hidrolik yang tepat guna. Pembuatan mesin tekuk plat hidrolik terbagi menjadi beberapa langkah yang harus dikerjakan dan dipersiapkan terlebih dahulu yaitu: Identifikasi gambar kerja, perencanaan pemilihan material, persiapan bahan, persiapan alat dan mesin, melakukan proses pengerjaan dan finishing. Bahan yang digunakan untuk membuat komponen dari mesin tekuk plat hidrolik yaitu dengan plat ST37 tebal 0,6 mm dengan komponen berupa part penjepit dengan ukuran 1400mm X 196mm X 307mm, part meja landasan dengan ukuran 1412mm x 156mm x 503mm, part penekuk dengan ukuran 1400mm x 250mm x 95mm, part Frame dengan ukuran 1000mm x 600mm. Sistem transmisi yang digunakan adalah sistem hidrolik untuk mendorong part penekuk. Lalu untuk mengangkat part penjepit plat dengan menggunakan sistem pengungkit pada kiri dan kanan mesin tekuk plat hidrolik. Mesin dan peralatan yang digunakan dalam pembuatan mesin tekuk plat hidrolik yaitu peralatan pengukuran, peralatan pengurangan volume, peralatan pengelasan, peralatan perakitan dan peralatan finishing.
Traducción y bilingüismo en el periódico al-Waqā’i‘ al-Miṣriyya:
Authors: Tagourramt El Kbaich Abdallah
Published: December 2024

al-Waqā’i‘ al-Miṣriyya es un periódico considerado como el antecedente de la prensa árabe en general y la egipcio-otomana en particular. Comenzó su publicación en turco-otomano y en árabe. Esta versión bilingüe se presentaba en los folletos de dicha gaceta en forma de dos columnas: una principal en el primer idioma a la derecha, y otra secundaria en el segundo a la izquierda. A medida que fue pasando el tiempo, esta posición privilegiada variaría según las circunstancias políticas que enfrentó el Egipto otomano durante el gobierno de la dinastía de M. ‘Alī. Dentro de este marco, se analizan los factores que contribuyeron al surgimiento de este bilingüismo, destacando el papel que desempeñó la traducción en él. Asimismo, se presta especial atención al contexto periodístico de la época para averiguar cómo al-Waqā’i‘ al-Miṣriyya logró moldear su propia trayectoria periodística, por un lado, y responder a las demandas de la prensa oficial, por el otro. Como resultado de la investigación, se reafirmará que la relación de interdependencia entre la prensa y la traducción aceleró y afianzó el proyecto periodístico que se estaba gestando en el Egipto otomano decimonónico.
Recursos bilingües y multilingües del dominio del turismo
Authors: Buendía Castro Miriam
Published: December 2024

La competencia fraseológica resulta fundamental para la traducción turística, por lo que los recursos terminográficos especializados en este dominio que contengan información fraseológica pueden ser de gran ayuda para el traductor e intérprete. No obstante, no existen numerosos diccionarios ni bases de conocimiento bilingües o multilingües especializados en el ámbito del turismo. El objetivo de esta investigación es describir y comparar cuatro recursos terminográficos que incluyen terminología del dominio del turismo del ocio en sus entradas, con el objetivo de poder asistir al traductor o intérprete en su labor de documentación y de extracción de información fraseológica, para la combinación inglés-español. En concreto, se han analizado los siguientes recursos: el Diccionario de términos de turismo y de ocio (Inglés-Español, Spanish-English) (Alcaraz-Varó et al., 2006), DicoAdventure (Durán-Muñoz, 2022), IATE y TERMIUM Plus. Los resultados muestran que los recursos analizados suelen incluir no solo unidades nominales, sino también unidades verbales y fraseológicas en sus entradas, un aspecto muy positivo que facilita la búsqueda para traductores e intérpretes. No obstante, el número de entradas dedicadas al turismo del ocio se encuentra todavía limitado en muchos recursos y el tratamiento de los equivalentes de traducción no suele ser sistemático.
Training Translators for the Tourism Industry in the L2/LSP Classroom through TV Series
Authors: Clouet Richard
Published: December 2024

This work is contextualised in the field of Translation and Interpreting, more precisely in tourism translation, and falls within the area of translator training. The study is part of a larger project on the adoption of strategies for the acquisition of intercultural communicative competence (ICC) by T&I students in second language (L2) classrooms. The article examines how the use of TV series can be an effective method not only to improve language competence, but also to enhance learners’ general knowledge of the foreign culture(s); to develop their intercultural awareness, especially through the use of subtitles (both same-language subtitles and translated subtitles); and to improve their translation skills, in this case, in relation to tourism translation. Thus, this paper argues that TV series help develop trainee translators’ intercultural awareness, prepare them to be professional intercultural mediators and they can be used as parallel texts for tourism translation. The paper includes a sample of task-based activities that can empower future translators in the tourism industry to overcome ambiguity and misunderstandings, and to achieve a fruitful dialogue between people of different cultures −a key aspect to be taken into account in the tourism industry. The study finally concludes with an evaluation of these activities supported by the results of a questionnaire administered to a group of students who benefited from the learning experience. The findings confirm their effectiveness in improving both translation and intercultural communication skills.
Smart sensors to reduce installation solid waste
Authors: Davidson Susannah , Miranda Ramirez Jaime , Matos Aguiar Atalia , Velazquez Lopez Mileisha , Adya Aditi , Urban Angela , Young Allison
Published: December 2024

Sensors were deployed by the research team in interior waste bins at Army installation buildings to collect data on waste generation at the source. The sensors were designed to provide granular data on waste generation that stakeholders can use to make informed decisions about solid waste man-agement. Each sensor costs about $300 to fabricate, but bulk fabrication may bring costs down. Sensors were deployed at dining facilities, offices, and barracks, which typically had higher waste volumes. Dining facilities were deemed to be the most useful application because at the other buildings, waste management either varies significantly or much of the waste is carried out directly to exterior waste bins. This technology shows promise but could be improved in areas such as sensor fit, sensor robustness, battery life, data storage, and clock accuracy. The highest return on investment would be found in areas with high costs for waste hauling and landfills. In areas with low waste management costs, this technology may not result in costs savings.
LA SENTENCIA DEL TEDH FRAGOSO DACOSTA C. ESPAÑA: UN PASO MÁS EN LA CONFUSIÓN ENTRE EL TEDH Y EL TC A CAUSA DEL DISCURSO DE ODIO
Authors: Pareja Ferrer Pablo
Published: December 2024

Hate speech is one of the principal areas of disagreement between Spanish Constitutional Court and the European Court of Human Rights. The most recent occasion on which was demonstrated was the ECHR Fragoso Dacosta v. Spain, which was the third consecutive condemnation of Spain for acts that the TC had qualified as hate speech. In this paper, though a jurisprudential examination of the doctrine of two courts, we intend to find out where the disagreement between the two courts lies, in order to elucidate a theorical path that could lead to a harmonization of the doctrine of both courts and avoid more condemnatory sentences in similar cases
Actividad cinegética y participación pública en la planificación y gestión de los espacios naturales protegidos: el caso del Parque Nacional de Monfragüe (España)
Authors: Martín Delgado Luz María , Rengifo Gallego Juan Ignacio , Serrano-Montes José Luis , Arias-García Jonatan
Published: December 2024

La superficie de las áreas naturales protegidas en España ha experimentado un notable incremento desde inicios del siglo XXI que ha afectado fundamentalmente al medio rural. Extremadura es un claro ejemplo de este escenario al presentar un carácter eminentemente rural en el que la superficie protegida representa más del 30% del territorio. La creación de este tipo de espacios ha desembocado en la restricción de determinadas actividades tradicionales ligadas a la explotación de los recursos endógenos que contribuyen a la generación de riqueza y a la necesaria diversificación productiva de los espacios rurales. Este es el caso de la actividad cinegética en los Parques Nacionales de España. Un claro ejemplo de este escenario lo encontramos en los límites del Parque Nacional de Monfragüe, donde la caza está prohibida desde el año 2020. Atendiendo a una planificación y gestión democrática de los espacios naturales protegidos, resulta fundamental la incorporación de la actividad cinegética en las estrategias de participación pública de los mismos. Por ello, en el presente trabajo se realiza, mediante un cuestionario un análisis sobre la percepción que la población local residente en el Área de Influencia Socioeconómica del Parque Nacional de Monfragüe tiene sobre la actividad cinegética. Por otra parte, se identifican las aspiraciones de la población local en relación con la planificación y gestión del espacio protegido en el actual escenario de abolición de la caza.
A New Load Rating Criterion Avoids Overdesigning Downhole Tools
Authors: Zhong Allan , Gar Shobeir Pirayeh
Published: December 2024

The traditional approach to designing completion tools can result in the inefficient use of materials and/or inaccurate or overly conservative load ratings for some applications. In this paper, we present a new load-rating criterion, the onset of global nonlinearity, which can more accurately represent the actual strength of downhole tools in those scenarios. Using the onset of global nonlinearity may allow for higher load and pressure ratings for a component than would be produced by traditional design approaches. This new load-rating criterion has been demonstrated through the first principal analysis, laboratory experiments, and field results in applications such as hydraulic fracturing, sand control tools, subsurface safety valves, and injector-producer cycles. The increased load and pressure ratings are most striking in high-pressure and high-temperature applications.

The prevailing load rating criteria for metallic tools are based on material yield strength. The initial yield criterion using von Mises stress, which dictates the load limit that a downhole tool can carry before exhibiting plastic deformation, is often used to design completion tools. However, for some applications of downhole tools, this load rating criterion can be overly conservative, limiting the design options unnecessarily. Several load rating criteria are evaluated and discussed considering the fundamentals of engineering mechanics. Based on our investigation, we propose a mechanics-based load rating criterion for applications where the number of peak load cycles is small and where small-scale yielding is allowed to occur in a localized area without causing major nonlinearity in the global scale. The load rating criterion is termed the onset of global nonlinearity.

Engineering mechanics for several widely used load rating criteria are discussed and their application ranges and limitations, if any, are identified. The proposed onset of global nonlinearity for applications with low numbers of peak load cycles was validated through experimental tests under burst and collapse pressures as well as tensile and torque loads. The global onset of nonlinearity has been successfully applied for applicable downhole tools in real projects.

A new load rating criterion for applications with low cycles of peak loading helps to use the load-carrying capacity of the material fully and safely. Applying the onset of nonlinearity approach typically yields a higher load rating, which may be as much as 1.5–2 times more than that defined by the initial yield criterion, when the tools operate in noncorrosive environments, the required peak load cycle number is small (e.g., less than 200), and the tool materials are ductile.
Galactose impairs motor performance and cerebellar signaling in young male Wistar rats
Authors: Ferreira Bruna Klippel , Paz-Simoes Thiago , Melo Thairine Neves , Gonçalves Patricia Felix Rolo , Kubrusly Regina Celia Cussa , Reis Ricardo Augusto de Melo , Neves Gilda Angela , Ferreira Gustavo Costa , Schuck Patricia Fernanda
Published: December 2024

Galactosemias are a group of inborn errors of galactose metabolism that causes different motor symptoms such as ataxia, tremor, and fine motor dysfunction. The objective was to investigate the cerebellar damage caused by an acute galactose administration. Thirty-day-old male and female Wistar rats were used. Animals were randomized into the following groups: I) galactose group, receiving a single subcutaneous administration of galactose; II) control group, receiving the vehicle solution under the same conditions. One, 3 or 24 h after administration, the animals were evaluated in the rotarod test. A lower motor performance was observed in male rats 3 hours after a galactose administration. This effect was not seen in females or with galactose exposure for 1 or 24 hours. The activities of acetylcholinesterase and choline acetyltransferase were found unaltered in the cerebellum of males 3 h after galactose injection. We also found lower TH levels in cerebellar hemispheres and higher TH levels in cerebellar vermis 3 h after galactose administration in male rats, without differences in MAO-A or MAO-B activities. Galactose administration resulted in lower p-CREB(Ser133) levels in cerebellar hemispheres, without altering p-CREB(Ser133) levels in cerebellar vermis of male rats. Finally, a decrease in TrkB-FL immunocontent (but not of TrkB-T levels) was observed in male cerebellar hemispheres. The signs and symptoms of galactosemic patients underscore the need to study galactose effects in males and females and in various brain areas. Our findings enhance the understanding of therapeutic mechanisms of catecholaminergic drugs, which are proposed as a potential therapy for galactosemia.
Unravelling Physical and Radiobiological Effects of Proton Boron Fusion Reaction with anionic Metallacarboranes ([o-COSAN]-) in Breast Cancer Cells
Authors: Belchior Ana , Alves Bianca C. , Mendes Edgar , Megre Francisco , Alves Luís C. , Santos Pedro , Nishimura Kai , Nakamura Hiroyuki , Teixidor Francesc , Viñas Clara , Sampaio Jorge Miguel , Marques Fernanda , Pinheiro Teresa
Published: December 2024

Background: Protons, which are considered low-LET (Linear Energy Transfer) radiation, have an average RBE (relative biological effectiveness) of 1.1, with a range from 0.7 to 1.6. Thus, increasing biological effectiveness is of high interest in radiation oncology, and one way to enhance this is by using radiosensitizers. The present work investigates the effectiveness of the proton boron fusion reaction (PBFR) at the cellular level, using the sodium salt of metallacarborane [3,3’-Co(C2B9H11)2]- (Na[o-COSAN]) as the boron source, aiming to explore the potential of this type of boron clusters as a radiosensitizer for proton therapy. Therefore, the main goal was to test the hypothesis that loading the cells with boron will favour the PBFR at energies close to the Bragg peak. This would enhance the radiation-induced biological effects through the production of alpha-particles.
Results: As expected, we observed higher biological damage in irradiated cells and the presence of [o-COSAN]- potentiated the damage. These results translate into a lower cellular viability, indicating that DNA damage imposed colonies smaller than their non-irradiated counterparts. This suggests that these damages either took longer time to be repaired or made the cells undergo less efficient survival mechanisms.
Conclusions: The radiosensitizing effect of [o-COSAN]- by strategic cellular 11B placement and proton irradiation intensifies the DNA damage, making the nucleus particularly susceptible and thus increasing the destructive capability of alpha-particles, generated in the nuclear fusion reaction, which may lead to increased cell mortality.
Evaluating Physician Concordance in Interpretation of Tracheobronchomalacia Diagnosis and Phenotyping Using Dynamic Expiratory Chest Computed Tomography
Authors: Cortes-Puentes Gustavo A. , Matatko Martin , Bartholmai Brian J. , Edell Eric S. , Lim Kaiser G.
Published: December 2024

Background: Tracheobronchomalacia (TBM) presents diagnostic challenges due to its nonspecific symptoms and variability in diagnostic methods. This study evaluates physician concordance in TBM diagnosis and phenotyping using chest computed tomography (CT) scans with dynamic expiratory views.
Methods: We conducted a retrospective cross-sectional study at Mayo Clinic Rochester, analyzing 150 patients with dynamic expiratory CT scans. Three specialists—a thoracic radiologist, a bronchoscopist, and a pulmonologist—reviewed identical CT scans, blinded to prior interpretations. Inter-rater agreement was assessed using Fleiss's Kappa for TBM diagnosis and Cohen's Kappa for TBM phenotype classification into six categories: No TBM, Excessive Dynamic Airway Collapse (EDAC), Crescent Type, Circumferential Type, Saber-Sheath Type, and Mixed Type.
Results: Among the 150 patients, 54 (36%) were diagnosed with TBM or EDAC. TBM was more prevalent in males, older individuals, and smokers. Agreement among specialists was substantial for TBM diagnosis (Fleiss’s Kappa = 0.61, p < 0.001) but moderate for phenotype classification (Fleiss’s Kappa = 0.52, p < 0.001). The highest concordance was between the thoracic radiologist and the pulmonologist (Cohen's Kappa = 0.68), while the lowest was between the bronchoscopist and other specialists.
Conclusion: There is substantial agreement in TBM diagnosis using chest CT scans with dynamic expiratory views, but moderate variability in phenotyping. Standardizing criteria and integrating pulmonary function testing could enhance diagnostic consistency and clinical relevance.
Impacts of Hazardous Noise Levels on Hearing Loss and Tinnitus in Dental Professionals: A Comprehensive Study
Authors: Zhang Celia , Young Andrew , Rodriguez Samantha , Schulze Karen A. , Surti Bina , Najem Fadi , Hu Jiong
Published: December 2024

Background
Hazardous noise exposure is an important health concern in many workplaces and is one of the most common work-related injuries in the United States. Dental professionals are frequently exposed to high levels of occupational noise in their daily work environment. This noise is generated by various dental handpieces such as drills, suctions, and ultrasonic scalers. Prolonged exposure to such noise levels is known to have adverse effects on hearing health. Despite the prevalence of occupational noise in dentistry, there is a paucity of comprehensive research specifically examining the prevalence of hearing loss and tinnitus in dental professionals.
Methods
To evaluate the prevalence of hearing loss and tinnitus, data were collected from 60 dental professionals including participant demographics and audiometric thresholds. Thresholds were compared to the age- and sex-based reference ranges from the International Standards Organization (ISO 7029:2017).
Results
Results showed that 15–25% of males and 13–18% of females had hearing thresholds that exceeded 95th percentile limits based on the ISO normative age- and sex-distributions. Tinnitus was reported in 40% of the participants.
Conclusion
This study is the first to offer a comprehensive examination of the characteristics and prevalence of auditory dysfuncions in dental professionals, when compared to the ISO normative age and sex distributions of hearing status. Findings from this study highlight the need for increasing the awareness of occupational noise hazards among dental professionals and the importance of routine audiologic monitoring.
Anatomical study of the vascularization of the pedicled osteo-myo-cutaneous scapulo-dorsal flap
Authors: Kany Alexia , Verdalle-Cazes Mikael , Vacher Christian , Foix Jean-Philippe , Crampon Frédéric , Deneuve Sophie , Nokovitch Lara
Published: December 2024

Purpose
The main objective of this study was to conduct an anatomical study of the composite flap described by Kany et al., including the harvesting of the medial border of the scapula associated with a skin paddle vascularized by a perforator from the superficial branch of the dorsal scapular artery (DSA), to clarify the potential causes of failure of this flap.
Methods
A radiological study was performed to study the anatomical variations of the dorsal scapular pedicle (origin, course of the deep branch of the DSA in relation to the medial border of the scapula, perforators from the superficial branch of the DSA). Perforators from the superficial branch of the DSA were also identified on anatomical subjects, and their cutaneous vascular territory was determined.
Results
The DSA originated from the transverse cervical artery in 95% of cases. The deep branch of the DSA was in a posterolateral position relative to the medial border of the scapula in 70% of cases, and in a posteromedial position in 30%. In most cases, between 1 and 2 perforators arised from the superficial branch of the DSA. The mean size of the cutaneous vascular territory arising from the perforators of the superficial branch of the DSA was 7.8cmx8.5cm.
Conclusion
When mandibular reconstruction with this flap is considered, a preoperative CT angiogram could ensure that the transverse cervical vessels have been preserved, and determine the position of the deep branch of the DSA relative to the medial edge of the scapula.
Increased nighttime land surface temperatures in a seasonally muggy climate
Authors: Muse Nkosi , McNoldy Brian , Clement Amy , Mach Katharine
Published: December 2024

Globally, increasing air moisture limits not only the human body’s ability to cool down, but also the Earth’s surface. A gap remains, however, in understanding how limited surface cooling can quantitatively impact metrics of thermal comfort. Here, we examine how air moisture influences nighttime land surface temperatures (LSTs) and thermal comfort during summer months across the Florida peninsula, during which time air moisture reaches the highest values of any place in the United States. For June–August during 2018–2022, we ask: 1) How do urbanicity, measured as impervious surface, and geography, measured as latitude and distance from the coast, modulate air moisture, measured as specific humidity? 2) How does specific humidity limit LST cooling at night? And 3) what are the resulting consequences for thermal comfort? Based on data from 30 weather stations along the peninsula, we find that specific humidity increases closer to the coast and at lower latitudes. In regions with higher air moisture levels, LSTs cool off less at night (as measured at 1 AM), resulting in lower differences between daytime and nighttime (diurnal) LSTs. Elevated nighttime LSTs have pronounced implications for measures of thermal comfort—for every 1.0 °C increase in nighttime LST, nighttime surface air temperatures increase, on average, by 1.1 °C, heat indices by 2.0 °C, and wet bulb temperatures by 0.5 °C. This analysis therefore underscores the importance of heat mitigation and adaptation strategies that reduce elevated nighttime LSTs in seasonally muggy climates, increasing thermal comfort.
Preparation of novel CO 2 copolymer diol and its application on waterborne polyurethane
Authors: Xian Wenqi , He Maoyi , Zheng Rui , Liu Zhu , Lu Ming , Chu Yuehuan , Cao Hao
Published: December 2024

CO2 copolymer diol (PPCD) with superior transparency is an indispensable raw material for the polyurethane polymers, especially for water-based polyurethane coatings. However, commercial PPCD is generally opaque. In this work, A novel sustainable, colorless and transparent PPCD was prepared by using carbon dioxide (CO2) and propylene oxide (PO) as raw materials. Its basic structure was tested and verified by Fourier transform-infrared (FT-IR) and proton nuclear magnetic resonance (1H NMR) spectroscopy. Appropriate increase CO2 content did not obviously reduce the transparency and thermal stability of PPCD and the optimum value was 29.1 wt.%. Furthermore, the waterborne polyurethane (WPU) was successfully synthesized by prepolymer method with poly(1,4-butylene adipate) (PBA), polypropylene glycol (PPG) or prepared PPCD as the soft segment, respectively. With the increase of CO2 content, the thermodynamic property of WPU was significantly improved. When CO2 content increased from 23.50 wt.% to 31.50 wt.%, the tensile strength increased from 23.27 MPa to 64.63 MPa and the elongation at break decreased from 750.85–520.37%, accompanied by the glass-transition temperature increased from − 49.7 ℃ to -34.5 ℃. In addition, the WPU prepared by PPCD was also found to have better tensile strength, transparency and storage stability than that prepared by PBA and PPG. A new inspiration was provided to develop high-transparent CO2 based water-based polyurethane coatings.
Assessment of Pediatric Thyroid Nodule Sonographic Features Applying the ACR TIRADS
Authors: Alasafwani Aqeelah , Kushaim Ayman
Published: December 2024

FNA is the recommended clinical approach in the conclusive diagnosis of thyroid nodules. ACR TIRADS assess the various criteria considered before performing the FNA/biopsy of any thyroid nodule. Even though these parameters are validated for adult patients, their use in pediatrics has not been well studied. This research looked in the accuracy of ACR TIRADS in pediatric cases. A retrospective study was done including children who presented with thyroid nodules. Participants were chosen if they were ≤ 14 years and had ultrasound imaging findings of thyroid nodules. Patients were excluded if they had an incidental thyroid nodule detected by other modalities with lack of baseline ultrasound scan, diffuse thyroid disease with no dominant nodule as seen in thyroiditis and Graves’ disease, diffuse heterogeneity, thyroidectomy, and infection/abscess/ phlegmon. 50 thyroid nodules were studied and half were malignant. The ACR TIRADS sensitivity was calculated as 95.8%. Size was also studied to consider its effect on malignancy risk. The research’s findings suggested that ACR TIRADS demonstrates good accuracy level for use in pediatric cases; however, size plays no significant role in the determination of malignancy risk of children’s thyroid nodules.
Investigation of the influence of simultaneous multi-level physical and auditory stressors on cardiorespiratory response
Authors: Buj Christian , Preuß Meret , Mörsdorf Maximilian , Schmidt Anke , Guckel Denise , Dumitrescu Daniel , Klein Franziska , Straetmans-Oehme Lisa , Eichelberg Marco , Hein Andreas
Published: December 2024

In occupational medicine, monitoring individual stress-related physiological responses is an effective tool for minimizing health risks at the workplace. From an audiology perspective, this particularly concerns the effects of auditory stress, which leads to increased listening effort with subsequent hearing fatigue. A study was conducted to investigate whether cardio-respiratory responses can detect the effects of a multi-level combination of physical and auditory stressors. To investigate their measurability and determine whether an interaction exists, a selection of cardio-respiratory vital parameters such as heart rate, features in the time 1 and frequency domain of the heart rate variability, breathing rate, respiratory minute volume and the respiratory quotient were analyzed. The results showed a significant main effect of physical stress on all assessed parameters. Auditory stress demonstrated a significant impact on breathing frequency , root mean square of successive differences of interbeat intervals, and the power components of the low and high frequency bands of the heart rate variability. No interaction between auditory and physical stressors was observed across any of the examined parameters. From these results we conclude that physiological responses to different sources of stress can be recorded within selected vital parameters, independent of external stimuli such as ambient noise. In an occupational context, we see potential in tracking individual auditory stress by monitoring cardio-respiratory parameters, especially breathing patterns. By knowing the individual (auditory) stress level, conclusions could be drawn about the worker’s ability to concentrate and further measures could be taken to combat safety risks in the work environment.
In Quest of An Authentic Identity – An Exploratory Study of Mental Health Assessment of Gender Incongruence in Urban India
Authors: Ranade Ketki , Shankarappa Mohan Raju , Kumar Neeraj , Somaiya Aryan
Published: December 2024

Last decade in India has seen increasing visibility and dialogue on trans health including gender affirmation interventions. This has been enabled by growing mobilisation and assertion from trans communities and a range of legal and policy changes supporting trans inclusion. In this paper, we focus on mental health assessment of gender dysphoria/ incongruence that is the first and an essential step for a transgender person in the Indian context to be able to access medical and surgical gender affirmation interventions. We discuss findings of a mixed-method, exploratory study conducted with 165 mental health professionals in three cities of India. In this paper we primarily present qualitative data on mental health professionals’ understanding of gender incongruence, their practice of assessment, rationale for the same and ways in which they end up gatekeeping access to medical and surgical gender affirmative interventions. Concepts such as biological determinism of gender, trans normativity, pathologisation of trans and gender diversity, mental stability and capacity are used to critically discuss findings.
Healthcare Access for Migrants in Iran: A Qualitative Study
Authors: ghiasi kanishka , Mosadeghrad Ali Mohammad , Dargahi Hossein , Jaafaripooyan Ebrahim
Published: December 2024

This study explores the accessibility of healthcare for migrants in Iran, focusing on the challenges faced by approximately 3.8 million migrants. Key barriers to access include legal status, financial constraints, and cultural differences. Through a review of documents and semi-structured interviews with 25 purposively-selected healthcare providers—such as government officials, healthcare professionals, and experts from international organizations working in migrant health. The research reveals significant disparities in healthcare access. Legal migrants generally receive essential healthcare assistance from the government and United Nation High Commissionaire for Refugees, while unauthorized migrants typically face high out-of-pocket expenses and difficulty obtaining necessary medical care. The findings highlight the importance of implementing more inclusive health policies that provide coverage for all migrants, regardless of their legal status, to reduce health inequalities. Recommendations include improving access to affordable health insurance, decreasing treatment costs, and promoting cooperation between government organizations and non-governmental organizations (NGOs) to ensure equitable healthcare for all. By addressing the unique health challenges encountered by diverse migrant populations, this research aims to improve public health outcomes in Iran and supports the argument for more comprehensive healthcare policies that prioritize the well-being of all residents.
Entrepreneurial Motivations and ESG Performance in Chinese Stock Exchange-Listed Companies: An Empirical Analysis
Authors: Cui Jun
Published: December 2024

This study explores the impact of entrepreneurial motivations on ESG performance in Chinese stock exchange-listed automobile companies. Using quantitative methods and empirical analysis via STATA, the research examines baseline stability, endogeneity, heterogeneity, and mediation/moderation mechanisms. A sample of 10 firms from the Shanghai and Shenzhen Stock Exchanges (2015-2023) was analyzed. Results indicate that entrepreneurial motivations positively influence ESG performance, mediated by innovation capability and moderated by market competition intensity. These findings offer theoretical and practical insights, aligning with Stakeholder and Institutional Theories. The study provides a robust framework for understanding strategic ESG behavior in China’s automobile sector.
Corrosion Resistance Analysis of Duplex Stainless Steel Surfaces Obtained by Milling
Authors: Policena Mauricio Rodrigues , Passari Emerson Santos , de Souza André João
Published: December 2024

Duplex stainless steels (DSSs) have been extensively applied in the petroleum, chemical, and energy sectors owing to their exceptional mechanical properties coupled with their high resistance to oxidation and corrosion. However, these advantageous characteristics come at the cost of diminished machinability. The milling of these challenging materials tends to produce grooved profiles on machined surfaces. This study investigated the surface integrity during dry face milling of four distinct types of DSS: LDX 2101, DX 2304, DX 2205, and SDX 2507. To explore the effects of the cutting parameters, such as the cutting speed (vc), feed per tooth (fz), and axial depth of cut (ap), a randomized Box–Behnken experimental design was employed. Notably, surface roughness exhibited significant variability, with the response variables (Ra and Rz) being concurrently optimized. Each DSS variant demonstrated specific optimal levels for the cutting parameters. Accelerated corrosion tests in accordance with the ASTM G48 standard revealed varying pit sizes, which were notably larger for LDX 2101 and DX 2304. The mass loss was correlated with the smallest medium maximum height of the profile (Rz). In instances where Rz ranged from 1.6 to 3.9 µm, 20 to 30 pits/mm2 were observed within scratches and grooves left by the milling tool. Energy dispersive spectroscopy (EDS) analysis revealed elevated levels of sulfur, indicating possible inclusions, and a high chromium content at the center of the pits.
Effect of enriched environment on the chronic sleep deprivation mice by NLRP3/Caspase-1 signal pathway
Authors: Tian Ruiqi , Zhou Yingying , Wei Tang , Yu Dandan
Published: December 2024

Enriched environment (EE) serves as a crucial intervention strategy that enhances central neural plasticity and facilitates motor, sensory, cognitive, and social stimulation. This multifaceted approach ultimately promotes the recovery of cognitive functions in the brain. However, the mechanism is unclear. Neuroinflammation has been proven associated with cognitive impairment. NLRP3 plays a crucial role in neuroinflammation induced sleep deprivation. Our study was to investigate the effect of EE on the chronic sleep deprivation mice by NLRP3/Caspase-1 signal pathway. In this study, the modified multi-platform method (MMPM) was applied to establish the chronic sleep deprivation model. The novel object recognition test (NORT) was used to assess the ability of learning and memory. The evaluation of hippocampal neuronal injury was achieved by performing Nissl staining and immunofluorescence. To evaluate the protein and mRNA expression of NLRP3, Caspase-1, and ASC, western blot and RT-qPCR were utilized. Compared with the SD group, the mice in the SD+ EE group demonstrated longer and more often to explore novel objects and alleviating neuroinflammation in the hippocampal. The mRNA and protein of NLRP3, Caspase-1, and ASC were decreased in the SD+ EE group. Enriched environment can improve the cognitive impairment induced by chronic sleep deprivation through the NLRP3/Caspase-1 signal pathway.
Evaluation of stability of Short Hybrid Implant Impression Copings: A Finite Element Analysis
Authors: Sun Minji , Yoo Je Hyeon , Jeong Yuwon , Kim Jong-Eun , Lee Hyeonjong
Published: December 2024

Objectives. This study evaluates the stability of various short hybrid impression copings with pick-up plastic components compared to conventional impression copings. Materials and Methods. Three-dimensional (3D) models were created using three different impression coping types (transfer, short hybrid [SH] with cap, and SH without cap) in two diameters (4.00 mm and 5.00 mm). An external horizontal load was applied to the apex of the analog to simulate unintentional forces under diverse conditions. Von Mises stress, microstrain, and displacement values were calculated to assess the stability of each group. Each group underwent a single simulation, and a Tukey post hoc test was conducted for statistical analysis. Results. The finite element analysis (FEA) results demonstrated that SH copings with a pick-up component showed significantly lower stress and deformation in the PVS material under unintended force application. Significant differences were observed among all groups (p < 0.01). Conclusions. Short hybrid implant copings with a pick-up cap provide reliable impression accuracy comparable to conventional transfer copings, with consistent reproducibility. Clinical Relevance Achieving precision and stability in dental implant impression techniques is essential for the accurate replication of intraoral conditions. Modifications to impression coping caps by some implant manufacturers have been introduced to enhance the ease of transfer and repositioning in clinical practice. In this study, the stability of impression copings with pick-up plastic components is evaluated using finite element analysis, providing insights into their clinical effectiveness.
Using Gypsum-modified Biochar to Adsorb Phosphate from Water: Adsorption Performance and Mechanism
Authors: Xu Guanli , Wu Di , Ao Xiang
Published: December 2024

This study explored the use of gypsum-modified biochar (GBC) for phosphate adsorption from water. GBC, composed of an equal weight mixture of gypsum (CaSO4·2H2O) and straw biochar subjected to pyrolysis, demonstrated strong resistance to interfering anions (NO3−, Cl−, and HCO3−) and high adsorption efficiency across a wide pH range (7–11). The adsorption behavior was well described by the Pseudo-Second-Order kinetic and Langmuir models, with a maximum capacity of 247 mg∙g−1 at 303 K. The adsorption mechanisms involved ligand exchange, electrostatic attraction, and micro-precipitation. These findings highlight GBC as a simple and effective adsorbent for phosphate removal.
Affinity ultrafiltration screening, multi-target extraction, and comprehensive activity verification of acetylcholinesterase inhibitors in the food additive Corydalis yanhusuo
Authors: Liang Jiaqi , Zhang Yuchi , Li Ruizhe , Zhang Yutong , Nong Yuyu , Chen Ming , Sun Ruijun , Li Sainan
Published: December 2024

Corydalis yanhusuo possesses strong medicinal value and is used in certain regions for soup making, wine frying, vinegar processing, and other edible processes. The anti-Alzheimer’s disease (AD) traditional Chinese patent medicine "Yangxue Qingnao Granules" contains C. yanhusuo. To explore the anti-dementia components of C. yanhusuo, this study used acetylcholinesterase (AChE) as the pointcut and screened, extracted, separated, and evaluated the biological activity of AChE inhibitors in C. yanhusuo. For the first time, affinity ultrafiltration combined with a matrix comprehensive evaluation of AChE inhibitor activity was used, and activity prediction analysis was conducted using a binding-degree growth trend fitting diagram. The response surface combined with pairwise Euclidean distances and Non-dominated Sorting Genetic Algorithm III technology was employed to classify various compounds, thereby optimizing the extraction of multiple active ingredients. Semi-preparative high-performance liquid chromatography was used to separate and purify the active compounds. The inhibitory effects and mechanisms of action of the active ingredients on AChE were verified through enzymatic reaction kinetics, and the potential anti-AD effects of the active ingredients were verified through network pharmacology. Finally, the differences in compound activity were comprehensively evaluated for the first time using a Pearson correlation matrix. The results revealed that six compounds in C. yanhusuo exhibited significant binding affinities for the AChE active site. This study provides valuable insights into the active compounds of C. yanhusuo and their potential anti-AD properties, promotes the development of AChE inhibitors from food and medicines, and provides an approach to reduce the side effects associated with synthetic drugs. This study provides a valuable reference for the exploration and development of functional materials from various medicinal resources.
IPA1 regulates long anther development through miR156-mediated DNA hyper-methylation and post-transcriptional gene silencing in Oryza longistaminata
Authors: Zhang Guofang , Sun Yue , Huang Tao , Liu Yuqing , Huang Longyu , Zhang Yue , Wang Yanfang , Huang Wenyue , Shao Kuitian , Ding Zhihu , Zhang Zhiyuan , Li Bai , Chen Zhongkai , Wang Zhengjie , Cai Yicong , Zhou Dahu , Ouyang Linjuan , Zhu Changlan , Peng Xiaosong , Xu Jianlong , He Haohua
Published: December 2024

Background: Oryza longistaminata, despite exhibiting robust rhizomes, elongated stamen and resilience against stresses, is unable to achieve self-pollination due to its inability to produce compatible female and male gametes within the same individual plant. Although the observed sterility may appear daunting, the distinct features of elongated anthers, substantial pollen grains, and a big pollen grain count offer breeders a desirable paternal line for hybridization and the intricate biological processes and profound implications during this pivotal stage of anther development remain enigmatic, piquing the curiosity of researchers.
Results: Through a rigorous multi-omics analysis during the anther development from the OlACD to OlAP stage, we discovered intricate correlations between alterations in methylation levels, siRNA variations, and transcriptional regulation within regulatory pathways, and the development of the anther during various fertile stages. This revelation highlights the intricate interplay between epigenetic and siRNA regulation in gene expression modulation. Our analysis pinpointed seven promising candidate genes, with a particular focus on IPA1. Phenotypic alterations in ipa1 mutants and overexpression miR156 revealed contrasting patterns in anther length and abundance and size of pollen grain, while 5’-Azacytidine treatment resulted in the opposite phenotype.
Conclusion: In essence, recent advancements in rice anther development are governed by two mechanisms: miR156-mediated IPA1DNA hyper-methylation leading to transcriptional gene silencing (TGS) and miR156silencing IPA1 expression through degradation and inhibition of complementary IPA1 mRNAs, resulting in post-transcriptional gene silencing (PTGS), both working synergistically to ensure precise regulation of rice anther development.
Temporal trends in novel drug target discovery reveal the increasing importance of human genetic data
Authors: Falaguera Maria J. , McDonagh Ellen M. , Ochoa David , Rusina Polina V. , Roldan-Romero Juan Maria , Hulcoop David G. , Leach Andrew R. , Dunham Ian
Published: December 2024

Drug approvals involving novel mechanism-of-action targets currently account for about one-fifth of new FDA-approved drugs each year. Developing therapies for novel targets carries added risks, but they can significantly address areas with unmet medical needs, or current treatment limitations. The Open Targets Platform is a valuable, regularly updated, open resource for identifying and prioritising therapeutic targets, integrating diverse data sources with a user-friendly interface. However, it lacks assessment of target novelty and has minimal timestamping. In response, we implemented comprehensive timestamping across millions of biomedical data points and introduced a metric to summarise the novelty of a target in the context of disease(s) to discover novel drug targets within the Open Targets ecosystem. A retrospective analysis of novel drug target approvals since 2000 suggests that the genetic evidence for clinical progression is increasingly considered earlier in the pipeline, highlighting the benefit of assessing association evidence in the context of time.
The Formation of the Conceptosphere of the “Digital Generation” Schoolchildren through the Application of a Linguoconcept-Centered Approach to Teaching Russian: a Theoretical Aspect
Authors:   Transbaikal State University, Vasilyeva Natalya V.
Published: December 2024

The formation of schoolchildren’s conceptosphere in Russian language teaching is an urgent task of
culturally-oriented linguistic methodology, which is solved by implementing linguo-conceptocentric approach
to teaching. In the context of modern educational practice, it is essential to consider not only the age-related
characteristics of students but also the specific attributes of those belonging to the ‘digital generations’ Z and
Alpha. In particular, they include stereotyping and high level of controllability. In this regard, in the process of
forming the conceptosphere of modern schoolchildren it is important to create conditions for their conscious
choice of worldview attitudes and value orientations, attitudes to certain cultural realities. The analysis and
generalization of scientific literature on the research topic revealed the prospects of forming the conceptosphere of modern schoolchildren through the construction of linguocognitive concepts in their consciousness.
The parallels between the structure of linguocultural and linguocognitive concepts are found and the connection between the formation of personality conceptosphere and the study of conceptosphere of culture is
clarified. The author has hypothesized that the formation of linguocognitive concepts in the schoolchildren’s
consciousness is possible in the intellectual activity of students. Moreover, the objective of such activity is to
gain an understanding of the linguistic and cultural concepts that underpin traditional Russian values. A comparison of the values and components of the conceptosphere of Russian culture has enabled the definition
of a list of concepts that show promise in the formation of the conceptosphere of schoolchildren of the ‘digital
generation’ and the linguo-conceptocentric approach implementation in teaching Russian. The list comprises
both constants of Russian culture and other concepts that facilitate the comprehension of traditional Russian
values.
Information technology for automation of sociological research: methods, technologies and advantages
Authors:   Tambov State Technical University (TSTU), Kuznetsov Alexander М.
Published: December 2024

The article is devoted to the analysis and development of an information-analytical system (IAS) for sociological research. It reviews existing software solutions for data collection, processing, and analysis, outlining their advantages and limitations. The article proposes integrating various functions into a single system to provide a comprehensive approach to research, including proactive forecasting and analysis. The developed IAS offers extensive capabilities for automating key stages of sociological research, improving data quality, and enhancing analytical accuracy. The integration of ontologies into the IAS structure has standardized terms and concepts, established semantic relationships between them, which reduced the likelihood of errors and shortened the preparation time for retrospective analysis (by 20%), while improving the quality of analytical conclusions through more in-depth and comprehensive data processing.