bluuebunny/crossref_metadata_2025 huggingface dataset:
Reaction of Epichlorohydrin with 2-aryl-4,5-dimethyl-1-hydroxy imidazole: A Combined DFT and Experimental Study
Authors: Behera Subham , Kumari Priyamvada , Panda Madhusmita Priyadarsini , Sangma Simon Watre , Bhunia Sabyasachi , Padhy Arun Kumar
Published: June 2023

This pandemic situation has made us to understand that we need to have look for more potential anti-viral agents in order to combat the SARS virus. During this period many existing anti-viral agents are directly being used to find their efficacy or being modified to increase their efficacy. In an ongoing effort to discover a noble series of imidazole-based epoxides, which can act as synthon for the synthesis of β-Amino alcohols, were designed and synthesized using a mild, efficient, and metal free approach starting from N1-hydroxy-2,4,5-trisubstituted-imidazoles and epichlorohydrin as precursor compound which may have higher potential to show biological activity. To support the experimental finding, we have performed Density Functional Theory (DFT) calculation. On the basis of the experimental findings and theoretical calculation we have drawn the reaction pathway that led to the product formation.
Integrated analysis of microRNA and messenger RNA expression profiles reveals functional microRNA in infectious bovine rhinotracheitis virus-induced mitochondrial damage in Madin-Darby bovine kidney cells
Authors: Ma Yingcai , Guo Xueping , He Qin , Liu Lu , Li Zelong , Zhao Xiaomin , An Feitong , Gu Wenxi , Zhong Qi , Li Na , Yao Gang , Ma Xuelian
Published: May 2023

Background
Studies have confirmed that Infectious bovine rhinotracheitis virus (IBRV) infection induces mitochondrial damage. MicroRNAs (miRNAs) are a class of noncoding RNA molecules, which are involved in various biological processes and pathological changes associated with mitochondrial damage. It is not known whether miRNAs participate in IBRV-induced mitochondrial damage in Madin-Darby bovine kidney (MDBK) cells.
Results
In the present study, we used high-throughput sequencing technology, Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis to screen mitochondria-related miRNAs and messenger RNAs (mRNAs). In total, 279 differentially expressed miRNAs and 832 differentially expressed mRNAs were identified in 6 hours (IBRV1) versus 24 hours (IBRV2) after IBRV infection in MDBK cells. GO and KEGG enrichment analysis revealed that 42 differentially expressed mRNAs and 348 target genes of differentially expressed miRNAs were correlated with mitochondrial damage, and the miRNA-mitochondria-related target genes regulatory network was constructed to elucidate their underlying regulatory relationships. The expression patterns of eight of ten differentially expressed miRNAs were consistent with the high-throughput sequencing results, Functional validation results showed that the overexpression of miR-10a and miR-182 aggravated mitochondrial damage and that the inhibition of miR-10a and miR-182 alleviated mitochondrial damage.
Conclusions
This study revealed not only the expression changes of miRNAs and mRNAs in IBRV-infected MDBK cells but also the possible biological regulatory relationship between them. MiR-10a and miR-182 have the potential to be developed as biomarkers for IBRV diagnosis and treatment. Together, these data and analyses provide additional insight into the role of miRNAs and mRNAs in IBRV-induced mitochondria damage.
Sediment thickness of subsurface anomalous Sources Determined by 2D/3D modeling of Potential field Gravity data: Implications for Sokoto Inland Basin Structures, NW, Nigeria
Authors: Abubakar Adamu , Likkason Othniel Kamfani , Maigari Abubakar Sadiq , Ali Sani
Published: June 2023

Due to the promising potential for hydrocarbon exploration in Nigeria's inland basin, more and more emphasis is being paid to the structural setting associated with these basins, especially the current Sokoto basin. Lacoste and Romberg's CG-725 gravimeter collected a sizable amount of potential field gravity data for relative measurements in the region, which is used in this work. The depth of the Earth's subsurface was investigated in this study, which also provided information on the most likely process of emplacement for the bodies that gave rise to the anomalous structures in the Sokoto inland basin. The regional field, a plane with a gradient of 0.38 mG/km and an approximate 10° northeasterly dip, was used as a technique for regional-residual separation. The relative amplitudes of the negative Bouguer gravity anomaly in the region range from − 27.38 mGal to -74.88 mGal. In the southern part of the study area, a large positive anomaly with amplitude of 16.2 mGal can be detected on the residual anomaly map. The main techniques for applying enhancement filters include 2D forward modeling, analytical signal and tilt of angle derivative, directional filtering, power spectrum analysis, Werner deconvolution, and 3D inversion. The 2D spectral depth analysis of gravity data along the rift axis (NE-SW) indicates that source depths tend to deepen toward the south. The joint 2D forward modeling of gravity data provided more evidence for this, demonstrating that the top of the basement slopes both in the NW-SE and N-S directions. The 3D gravity model's findings concur with those derived from methods for estimating depth and surface geological properties. Two depth estimates—1.8 km and 2.93 km—that roughly match the locations of two density boundaries were obtained using the gravitational power spectrum analysis. In the up-dip parts of the Taloka and Gundumi-Illo Formations, intrusions were found at depths of 10–20 km and 5–10 km, respectively, according to gravity modeling of the upper crust. The quaternary faults and fractures in the Eocene sediment at Gwandu Continental Terminal are essential for the sediment cover of the regional hydrocarbon system.
Spatial planning constraints will mitigate the fragmentation trajectory of natural and semi-natural landscapes: A case of Lushan City, China
Authors: Zhang Zhiduo , He Geng , Cai Wenbo , Zhu Qing , Cai Yongli
Published: May 2023

Context
The biodiversity of ecosystems is under severe threat from landscape fragmentation resulting from rapid urbanization. To understand the future trajectory of landscape patterns, it is imperative to examine the impact of current spatial planning constraint policies on the preservation of natural and semi-natural landscapes, as well as the promotion of ecosystem services and sustainability.
Methods
We employed a Patch-generating Land Use Simulation (PLUS) model to simulate and predict the land use and landscape pattern alterations in Lushan City under two distinct scenarios: "Planning Constraints (PC)" and "Natural Development (ND)". Subsequently, we identified an appropriate Landscape Fragmentation Index (LFI) that effectively captures the essence of fragmentation. To determine the optimal scale, we adopted an experimental approach using both the Moving Window (MW) method and the semi-variance function. By constructing a spatiotemporal sequence of LFI and the following trend analysis, we selected the Potential Fragmentation Areas (PFA) with significant tendencies toward landscape fragmentation.
Results
The spatial planning constraints 1) would prevent the encroachment of construction land into 2.14 km2 of cropland, 0.21 km2 of forest, and 0.13 km2 of grassland; 2) shift the highly fragmented area from the northeastern portion of Lushan to the planned area defined by the development boundary; 3) will mitigate and decelerate the trend of landscape fragmentation in natural and semi-natural landscapes, decrease PFA by 7.74 km2 and preserve 15.61 km2 of natural landscapes.
Conclusions
Spatial planning constraints have effectively controlled the expansion of the construction land. This control mechanism has greatly protected natural and semi-natural landscapes and ensured the conservation of habitats. Moreover, it provides an opportunity to incorporate landscape fragmentation risk considerations into future eco-management optimization.
The Application of Computer Virtual Reality Technology in Dance Movement Analysis
Authors: Li Lei
Published: May 2023

With the development of virtual reality systems for dance movements. Do a simple grooming. Designed a virtual reality system for Tai Chi exercise training. The system will generate virtual images of Tai Chi coaches and learners. Learners can observe the coach's images and imitate their movements until their own virtual images in the system and coaches. until the video action is consistent. New science and technology play an increasingly important role, and big data, artificial intelligence and virtual reality technology gradually penetrate into the daily life process. Due to the requirements of comprehensive quality education proposed by the overall national strategy, the emphasis on sports dance has gradually increased. In order to realize the diversified content expansion of sports dance, to explore the application research movements, and to excavate models with operational significance are the main strategic directions of discussion. However, due to the complex movements and repeated actions of music and dance videos, it is more difficult to conduct content-based video clip retrieval research on dance videos, and it is difficult to meet the user's requirements for video retrieval detection accuracy. The time sequence factors, granularity factors, interference factors, etc. Taking all aspects into consideration, video clips similar to the query clip are selected by comparing the similarity.
Waterborne exposure during non-consumptive domestic use of surface water: a population study across WASH service levels in rural India
Authors: Daniels Miles E. , Pradhan Ashirbad , Odagiri Mitsunori , Jenkins Marion W.
Published: May 2023

Exposure to pathogens from domestic use of surface water is understudied. In many low- and middle-income countries, surface water is used for hygiene, sanitation, amenity, and recreational purposes. In this study, self-reported use of and structured observations at community ponds were collected to measure waterborne exposure across water and sanitation service levels in a rural population of Khorda District, India. Overall, 86% of households (n = 200) reported using ponds on a regular basis. Among observed people (n = 765), 82% put water into their mouth at least once, with a median frequency of five occurrences per visit. Reported and observation data were combined to estimate the proportion (p) of the population that put water in their mouth at least once per day, and their mean daily rate of oral exposure (OE). These were highest for individuals with neither safely managed water nor basic sanitation access (p = 93%, OE = 14 day−1), but still high among those with both (p = 67%, OE = 6 day−1). The results suggest widespread exposure to waterborne pathogens in settings where non-potable surface water bodies continue to be used for domestic purposes, even among households with access to safely managed drinking water.
Role of Circular RNAs in Prostate Cancer
Authors: Chen Feng , Zhang Fa , Liu Yong-Qiang , Leng Yu-Fang
Published: June 2023

Objectives:

This study aims to summarize the current literature to demonstrate
the importance of circular RNAs (circRNAs) in multiple aspects of prostate cancer (PCa)
occurrence, progression, and treatment resistance and explore the potential role in therapeutic
strategies aimed at targeting this molecule in PCa.

Methods:

The relevant literature from PubMed and Medline databases is reviewed in this
article.

Results:

Non-coding RNA has been proven to play a vital role in regulating tumor progression.
Among them, circular RNA plays a more unique role due to its nonlinear structure.
Lots of circRNAs were found to be differentially expressed in PCa and regulate cell
signaling pathways by regulating particular gene expressions. Recent studies have demonstrated
that circRNAs are associated with the chemoresistance of urinary tumors, suggesting
that circRNAs might be a novel therapeutic target and a marker for therapeutic response
and prognosis assessment.

Conclusion:

The potential crosstalk of circRNAs modifications in PCa development,
therapy, and regulation of tumor metabolism is portrayed in this review. However, more
preclinical and clinical trials of this targeted strategy are necessary for the treatment of
urinary tumors.
Dysregulation of Transfer RNA-derived Small RNAs that Regulate Cell
Activity and its Related Signaling Pathways in Human Cancers
Authors: Fang Shuai , Liu Kaitai , Huang Tianyi , Du Juan , Chen Chujia , Zheng Zhen
Published: June 2023

tsRNAs are small noncoding RNAs that originate from tRNA cleavage and play important
regulatory roles in gene expression, translation, transcription, and epigenetic modification. The
dysregulation of tsRNAs in cancer disrupts gene expression and perturbs various cellular activities,
including cell proliferation, apoptosis, migration, and invasion. Moreover, tsRNAs may influence cancer
development by regulating related cell signaling pathways. In this review, we first examine the origins
and classification of tsRNAs and their effects on tumor cell activity. To highlight the latest research
progress of tsRNAs and signaling pathways, we summarize the possible mechanisms of tsRNAs
in specific tumor-related signaling pathways, including the Wnt, TGFb1, MAPK, PI3K-AKT,
Notch, and MDM2/p53 signaling pathways, that have been identified in recent research.
ERK/MAPK Signalling Pathway Regulates MMP2 through ETS1 in
Renal Clear Cell Carcinoma
Authors: Chen Hai-Bin , Li Wei , Yang Zhan , Liu Kai-Long , Lu Bao-Sai , Wang Zi-Yi
Published: May 2023

Background:

The c-ETS-1 (ETS1) expression is high in clear cell renal cell
carcinoma (ccRCC) tissues; however, how it impacts ccRCC is currently unknown.

Method:

The online STRING web source was used to construct a protein network
interacting with ETS1. The Cell Counting Kit-8 was used to detect the cell viability. A
clonogenic assay, a wound-healing assay, and a Transwell assay were used to detect
cell proliferation, invasion and migration abilities. Western blot was used to detect the
expression of proteins.

Result:

The data showed the expression of ETS1 in ccRCC tissues to be significantly
increased compared to adjacent tissues (p<0.05). The positive expression of ETS1 in
ccRCC patients aged 20–100 was statistically significant compared to adjacent normal
tissues (p<0.05). The grade of ETS1 positive expression (1-4) and lymph node
metastasis (N1) in ccRCC were significantly higher than those in adjacent normal tissues
(p<0.05). The tumour stage (stages 1-4) in ccRCC patients with positive ETS1 expression
was significantly higher than that in adjacent normal tissues (p<0.05). Knockdown
of ETS1 and PERK inhibitors significantly inhibited the proliferation, migration and
invasion of ccRCC cells. Knockdown of ETS1 inhibited MMP-2 expression, and an
extracellular signal-related kinase (ERK) inhibitor inhibited both ETS1 and MMP-2
expression.

Conclusion:

A high expression of ETS1 is associated with the progression of ccRCC.
This study suggests that ETS1 promotes proliferation by increasing MMP2 expression in
ccRCC, and combined knockdown of ETS1 and inhibition of ERK can significantly inhibit
the proliferation, migration and invasion of ccRCC. ETS1 may be a therapeutic and
prognostic target for renal cell carcinoma.
The Role and Application of Fibroblast Activating Protein
Authors: Zhang Xiao-lou , Xiao Wang , Qian Jian-ping , Yang Wan-jun , Xu Hao , Xu Xing-da , Zhang Guo-wei
Published: June 2023

Fibroblast activation protein-α (FAP), a type-II transmembrane serine
protease, is rarely expressed in normal tissues but highly abundant in pathological
diseases, including fibrosis, arthritis, and cancer. Ever since its discovery, we have
deciphered its structure and biological properties and continue to investigate its roles in
various diseases while attempting to utilize it for targeted therapy. To date, no significant
breakthroughs have been made in terms of efficacy. However, in recent years, several
practical applications in the realm of imaging diagnosis have been discovered. Given its
unique expression in a diverse array of pathological tissues, the fundamental biological
characteristics of FAP render it a crucial target for disease diagnosis and immunotherapy.
To obtain a more comprehensive understanding of the research progress of
FAP, its biological characteristics, involvement in diseases, and recent targeted
application research have been reviewed. Moreover, we explored its development trend
in the direction of clinical diagnoses and treatment.
Cardiovascular Protection of Aspirin in Chronic Kidney Disease Patients:
An Updated Systematic Review and Meta-Analysis
Authors: Chen Ting , Deng Yunlei , Gong Rong
Published: June 2023

Purpose:

To evaluate aspirin's cardiovascular (CV) protective effect in chronic kidney disease
(CKD) patients.

Methods:

We searched PubMed, Embase, Cochrane Library, and Web of Science (up to December
2022) for randomized controlled trials (RCTs) and observational studies comparing aspirin with placebo
in CKD patients for the prevention of CV disease (CVD). Efficacy outcomes included CVD, heart failure,
myocardial infarction, stroke, CV and all-cause mortality; safety outcomes included major bleeding,
minor bleeding, and renal events.

Results:

Six RCTs and 6 observational studies, including 35,640 participants, met the inclusion criteria
and reported relevant CV outcomes, with a mean follow-up of 46.83 months. The pooled data showed
aspirin had no significant preventive effect on CVD events (RR=1.03; 95% CI, 0.84-1.27). However,
CV mortality was significantly reduced in the aspirin group (RR=0.74; 95% CI, 0.58-0.95). Furthermore,
aspirin use did not increase the risk of major bleeding and renal events but significantly increased
minor bleeding events (RR=2.11; 95% CI, 1.30-3.44). Renal events were significantly increased after
sensitivity analysis (RR=1.10; 95% CI, 1.04-1.16).

Conclusion:

Aspirin did not prevent CV events, with a significantly increased risk of minor bleeding
and renal events. Besides, aspirin use had no statistically significant reduction in the risk of all-cause
mortality but had a statistically significant reduction in the risk of CV mortality.
1-Cyanoacetylthiosemicarbazides: Recent Advances in their Synthesis,
Reactivity in Heterocyclization, and Bio-Applications
Authors: Bondock Samir , Alabbad Nada , Hossan Aisha , Abdou Moaz M.
Published: May 2023

The synthesis of 1-cyanoacetylthiosemicarbazides is at the apex attention of researchers
due to their multifaced reactivity as versatile precursors in the synthesis of mono-, bi-, and
fused_heterocyclic compounds as well as metal complexes. Despite this, no comprehensive survey
was, so far, dedicated to the synthesis, chemical transformation, and bioactivities of this relevant
family of synthetic organic precursors and their derivatives. The present survey aims to summarize
an up-to-date record of the preparation of 1-cyanoacetylthiosemicarbazides and their chemical
transformation. A particular focus is given to their metal complexes and bio-applications
Recent Progress for the Synthesis of Pyrrole Derivatives – An Update
Authors: Patel Dharti , Shah Drashti , Patel Krishi , Patel Ayush , Bambharoliya Tushar , Mahavar Anjali , Patel Ashish
Published: June 2023

Pyrrole is a versatile heterocyclic moiety exhibiting a wide range of pharmacological actions
with high therapeutic value. The importance of pyrrole in the pharmaceutical field lies in its
versatility, selectivity, and biocompatibility, and these properties make it a valuable tool for drug design
and development. The pyrrole moiety is a fundamental building block for many biologically active
molecules and has gathered significant attention in the fields of medicinal and organic chemistry;
hence, its synthesis has been a crucial area for research. There are various conventional as well as
modern approaches to acquiring a series of pyrrole scaffolds, with a wide range of attractive features
and drawbacks pertaining to each approach. An extensive amount of literature must be studied to
compare the best synthetic routes. This article highlights the applications of pyrrole derivatives in
various fields, such as drug discovery, material science, and catalysis, and provides an overview of
modern synthetic pathways that include metals, nanomaterials, and complex heterogeneous catalysed
methods for pyrrole derivatives. Special emphasis is given to the use of green chemistry principles
like green solvent-based methods, microwave-aided methods, and solvent-free methods in the synthesis
of pyrroles, with the recent developments and prospects in the synthetic and organic chemistry
fields. Overall, this review article provides a comprehensive overview of the synthesis of pyrroles
and complies with all the possible developments in the synthetic routes for pyrroles within 2015–
2022. Among all, the reactions catalysed by proline, copper oxides, and oxones have been shown to
be the most effective synthetic route for pyrrole derivatives at mild reaction conditions and with excellent
yields. This information will be helpful for researchers interested in the development of new
pyrrole-based compounds. The categorization in this review provides an easy means for the reader to
rationally select the best possible synthetic method for pyrrole derivatives.
Electrical and Electromagnetic Stimulation of Living Organisms and the
Theory of a Cancer Formation Center
Authors: Bryzgalov Arkadiy
Published: June 2023

Electrical conductivity plays a pivotal role in the life of organisms. Processes, such as neural
information transfer, which allows a living organism to receive information and respond to it within the
shortest time possible, are the basis of electrical conductivity. However, electrical conductivity is not
only responsible for transmitting information. It provides living organisms the capability to encode this
information, execute control processes and launch a complex system of reflex-related, behavioral and
mental processes. Electrical conductivity is responsible for the control over all the functional systems of
our body. An in-depth study of the electrical activity of the body will allow us to make an important
conclusion on the presence of a functional control system in malignant tumors. A deep understanding of
the basics of electrical stimulation and signal conduction will give us insights into the sphere of control
and synchronization system within our central processor (brain) and other functional systems that we
need for the proper functioning of human body; these systems are also capable of altering the natural
physiological functioning of the body.
Your Hormones and Your Life Patterns Are Like a “Lock” and a “Key”
Authors: Sattar Tabinda
Published: June 2023

This opinion-based article discusses how our lifestyles regulate hormone levels in our
bodies and how hormones regulate our healthy life patterns. In fact, these two have such an important
aspect over each other that they are as important as a key is for a lock and vice versa.
Since these are equally important for each other, this opinion will help people understand the importance
of our lifestyles for our hormones and the necessity of balanced hormonal levels for our
healthy life patterns.
Macrocystis pyrifera: A Potential Source of Bioactive Compounds
Authors: Pérez-Alva Alexa , Ramírez-Rodrigues Melissa A. , Baigts-Allende Diana K. , Martínez-Jiménez Luz Andrea , Ramírez-Rodrigues Milena M.
Published: June 2023

Background:

The Mexican brown seaweed Macrocystis pyrifera is currently
unexploited. While this seaweed harvested in other regions has been characterized, changes in the
composition can be observed, making it relevant to have a better understanding of the Mexican
variety.

Objective:

The objective of this study was to perform a characterization of the Mexican seaweed
M. pyrifera in terms of phenolic and carotenoid profiles, mineral content, antioxidant activity, and
chemical composition.

Methods:

Chemical composition, mineral content, total phenolic content (TPC), and antioxidant
activity (ORAC) were measured. Also, the phenolic compounds and carotenoids were quantified
using an HPLC coupled with a triple quadrupole mass spectrometer detector.

Results:

Carbohydrates (48.81 ± 0.05%) were the most abundant macronutrient, while lipids represented
only 0.23 ± 0.01 % of the total. From the analyzed minerals (Na, Ca, P, K, and Mg), K
was the most abundant with 15,545.23 ± 23.72 mg/100 g. To quantify the phenolic compounds,
TPC, and ORAC, two extracts were used (water, and methanol: water (90:10 v/v)), for the carotenoid
profile only the latter was used. The most abundant phenolic compound was phloroglucinol
(4.45 ± 0.21 μg/g). Ten carotenoids were identified, fucoxanthin the most abundant (1,124.93 ±
3.4 μg/g). Finally, while there was no significant difference (p > 0.05) in the TPC, with values
ranging between 16.07 and 17.01 mg GAE/ g, the methanol: water (90:10 (v/v)) extract presented
a significantly higher (p < 0.05) antioxidant activity.

Conclusion:

The characterization of this seaweed can help to determine its potential for several
applications.
Mapping the Nanotechnology Patent Landscape in the Field of Cancer
Authors: Sun Haoyu , Wu Tong , Liu Xinrui , Xia Huanzhang , Yuan Hongmei
Published: June 2023

Background:

Currently, cancer is still a significant disease that seriously endangers human
health. Therefore, advanced diagnostic technology and treatment protocols are urgently needed. The
rapid development of nanotechnology is expected to provide new ideas for cancer diagnosis and treatment.

Objective:

The research aims to comprehensively demonstrate the hotspots of nanotechnology applications
in cancer.

Methods:

In this study, an International Patent Classification codes co-occurrence network is constructed
to visualize the technology landscape by simultaneously locating and ranking technologies that play
an integral role in nanotechnology diffusion and bridging in the field of cancer. In addition, community
identification and topic modeling highlight the latent topics in patent documents.

Results:

The visualization results of the patent network yield five main clusters: Cluster 0 is a nanoparticle
composition delivery system with liposomes as the primary carrier. Cluster 1 is mainly represented
by nano-immunotherapy with immune checkpoint inhibitors. Cluster 2 is nano phototherapy based on
photodynamic therapy and photothermal therapy. Cluster 3 is diagnostic imaging involving nanotechnology.
Cluster 4 is a drug delivery system with nanovesicles and albumin nanoparticles as carriers.

Conclusion:

It was found that carriers represented by liposomes, vesicles, and albumin nanoparticles
are essential nanomaterials in the current anticancer drug delivery systems. Integrating next-generation
immunosuppressants and nanotechnology will become an important development direction for future
immunotherapy. Organic/inorganic nanomaterials are pivotal in cancer imaging diagnosis and phototherapy.
Phytoestrogens in Menopausal Hot Flashes: A Review Article
Authors: Kargozar Rahele , Azizi Hoda , Yousefi Mahdi , Pourhoseini Seyedeh Azam , Naghedi-Baghdar Hamideh , Ghazanfari Seyed Majid , Salari Roshanak
Published: May 2023

Background:

Menopause is a biopsychosocial phenomenon in a woman’s life, and it
occurs at about the age of 48-55 years. Factors such as smoking, the number of children, early puberty,
and social class can cause early natural menopause. Symptoms that occur during menopause
include headache, mood disorders, insomnia, distraction, hot flashes, vaginal dryness, and sweating.
The most common symptom is hot flashes, which affect 85% of women with menopause. Recently,
people are showing more tendencies toward alternative therapies and herbs phytoestrogens.
Objective: This review aims to introduce the mechanism of herbal phytoestrogens controlling hot
flashes during menopause.

Methods:

Our searches were performed in the databases of PubMed, Scopus, and Cochrane. English
clinical trials, that investigated the effects of phytoestrogen plants individually or in combination
on the treatment of hot flashes in menopause were analyzed. After reviewing articles and
meeting the inclusion and exclusion criteria, 18 articles were selected.

Results:

In this study, 18 clinical trials of 2351 female patients were analyzed. The phytoestrogen
plants studied include soy, red clover, cohosh, hops, flax, pomegranate, anise, and Vitex Agnus.

Conclusion:

Studies have shown the beneficial effects of phytoestrogens in controlling hot flashes,
but in some cases, including soybeans, there are contradictory effects. Therefore, more clinical trials
are needed to achieve reliable results to confirm the phytoestrogen effects of herbal medicines.
Pandangan Disabilitas dan Aksesibilitas Fasilitas Publik bagi Penyandang Disabilitas di Kota Malang
Authors: Thohari Slamet
Published: May 2023

The paper traces how people in Malang percieve people with disabilities, therefore it looks for the base-line of accessibility on public services for people with disabilities as well. It’s nased on a reseach used a quantitaif method in which we use samples based on the standard regulated by goverment. On the other hand, a survey on perception of people with disability in Malang, it used clustering method which is investigating disability issues to people in Malang based on area already pointed out. Our Finding shows that people in Malang beleived that people with disabilities are “unperfect people”, therefe they still beleive on special schools. The other results showed that public services in Malang are not accessible for people with disabilities. The trend data showed that almost of public facilities are categorized as “not accesible”, only some can be categorized as “less-accesibble” and 0% of public facilities are “accessible.
Design Of Environmental Conditions Of Transportation Simulation Instruments On Tomato (Solanum Lycopersicum)
Authors:   Institut Teknologi Sumatera, Mufidah Zunanik , Jody Abdul Rachman ,   Institut Teknologi Sumatera, Fil'aini Raizummi ,   Institut Teknologi Sumatera, Telaumbanua Mareli ,   Universitas Lampung, Fatikhunnada Alvin ,   Institut Teknologi Sumatera
Published: May 2023

Based on data from Badan Pusat Statistik (BPS) in 2017-2018, the tomato productivity in Indonesia has seen a year-on-year increase of 10% and 19%. However, during the transportation process of agricultural commodities, excessive vibration can lead to damage of tomato commodities. Therefore, the purpose of this study is to develop an environmental data recording device using Arduino technology, and to assess its performance by simulating vibration during transport. The aim is to ensure proper handling and storage of tomato commodities in the distribution process. The designs used are programming designs, functional designs, and structural designs. The results showed that the design of an arduino-based environmental data recording instrument, calibration results between the DHT22 sensor (temperature) and a digital hygrometer yielded a correlation equation value of y = 1.0475x – 1.5575, R2 for the DHT22 sensor was 0.9885, and for the calibration results between the vibration sensor and the vibrating table as a calibrator obtained a correlation equation value of y = 1.9471x-101.24, the calibration R2 value was 0.8088, the instrument accuracy performance test results were obtained by 80%. The stability test results of reading past the setting point, the control speed is 4.04 minutes, the result of the reliability coefficient value (r11) is 0.90. The reliability coefficient value from the stability test results is included in the very high reliability category, the system response at a setting point of 150 RPM takes 63 seconds and the system response at a setting point of 200 RPM takes 71 seconds. characteristics that occur in tomatoes during the transportation simulation process where at 100 RPM the test was carried out, the tomatoes experienced a collision and only a few were bruised due to the shock from the transportation simulation the tomatoes were damaged and collided between the tomatoes in the box, the greater the vibration received by the tomatoes on during the transportation simulation, the more tomatoes will experience physical damage.Test results on tomatoes with a degree of mechanical damage (bruises) due to vibration during transportation. In stack 1 100 RPM there was no damage to the fruit while the biggest bruising occurred in stack 3 with 200 RPM.
PERKEMBANGAN RIAS DAN BUSANA PENGANTIN GAYA YOGYAKARTA PADA MASYARAKAT JOGJA TAHUN 2015-2021
Authors: Hariani Firi Oktavia , Hamidah Siti
Published: May 2023

Penelitian ini bertujuan untuk mengeksplorasi perkembangan tata rias dan busana pengantin gaya Yogyakarta pada masyarakat kota Yogyakarta tahun 2015 hingga 2021. Objek pada penelitian ini adalah perkembangan tata rias dan busana pengantin gaya Yogyakarta. Subjek penelitian ini adalah pasangan pengantin masyarakat kota Yogyakarta, anggota HARPI Melati Yogyakarta, dan dokumen berupa foto pasangan pengantin. Pengumpulan data dilakukan dengan observasi studi pustaka, wawancara, dan studi dokumentasi. Teknik analisis data dilakukan dengan pengumpulan data, reduksi data, klasifikasi data, penyajian data, dan pengambilan kesimpulan. Hasil dari penelitian menunjukkan adanya perkembangan tata rias dan busana pengantin gaya Yogyakarta pada masyarakat Jogja. Perkembangan pada tata rias disebabkan dengan adanya faktor dari alat dan bahan kosmetik yang semakin beraneka ragam, sehingga dapat disesuaikan dengan kebutuhan dan selera dari perias maupun konsumen. Perkembangan pada busana disebabkan oleh faktor kepraktisan dan penghematan waktu dalam pemakaian busana itu sendiri. Secara keseluruhan dapat disimpulkan bahwa perkembangan tersebut dikarenakan adanya faktor perubahan trend, selera, agama, dan kepraktisan dalam penyelenggaraan pesta pernikahan.
Does an Internet-Based Emotion Regulation Intervention Provide Added Value for Acute Psychiatric Inpatient Care? Protocol for a Randomized Controlled Pilot Trial
Authors: Bielinski Laura Luisa , Wälchli Gwendolyn , Nissen Christoph , Berger Thomas , Moggi Franz
Published: May 2023

Background

There is a lack of studies on internet-based interventions in inpatient settings. This is especially true for studies of internet-based interventions in acute psychiatric inpatient care. Internet-based interventions in this specific setting may provide benefits such as patient empowerment and overall improved treatment outcomes. However, there may also be specific barriers to their implementation that are unique due to the complexity of acute psychiatric inpatient care.

Objective

The aim of this study is to examine the feasibility and preliminary evidence for effectiveness of a web-based emotion regulation intervention provided as an add-on to acute psychiatric inpatient care.

Methods

The goal is to randomly allocate 60 patients with a range of different diagnoses in a 1:1 ratio to either treatment as usual (TAU), which consists of acute psychiatric inpatient treatment, or to the intervention group, which will receive TAU plus access to a web-based intervention that focuses on reduction of emotion regulation difficulties and improvement of emotion regulation skills. The primary outcome is symptom severity, assessed with the short form of the Brief Symptom Inventory at baseline, after 4 weeks, after 8 weeks, and at hospital discharge. Secondary outcomes include 2 emotion regulation parameters, intervention use, usability, patient satisfaction, and reasons for patient loss to follow-up.

Results

Participant recruitment started in August 2021 and as of March 2023 was ongoing. First publication of study results is expected in 2024.

Conclusions

This study protocol describes a study that intends to examine a web-based emotion regulation intervention in acute psychiatric inpatient care. The study will provide information on the feasibility of the intervention and possible effects on symptom severity and emotion regulation. The results will provide new insights on blended treatment, in this case the combination of a web-based intervention and face-to-face psychiatric treatment, in an understudied patient group and setting.

Trial Registration

ClinicalTrials.gov NCT04990674; https://clinicaltrials.gov/ct2/show/NCT04990674

International Registered Report Identifier (IRRID)

DERR1-10.2196/47656
Older Adults’ Pain Outcomes After mHealth Interventions: Scoping Review (Preprint)
Authors: Shade Marcia , Kovaleva Mariya , Harp Kimberly , Martin-Hammond Aqueasha
Published: May 2023

BACKGROUND

Pain is prevalent and poorly managed in older adults. Although pain self-management strategies are helpful, adoption and access are limited; thus, technology provides an opportunity for intervention delivery. Mobile health (mHealth) is feasible to use in older adults; however, we have yet to understand the effect of mHealth pain self-management interventions on pain outcomes in older adults.

OBJECTIVE

The purpose of this scoping review is to examine the characteristics of mHealth interventions and their efficacy on pain outcomes in older adults with musculoskeletal pain.

METHODS

With the assistance of a medical librarian, keywords and subject headings were generated, including but not limited to mobile health application, mHealth, digital, pain, pain management, and older. A search was conducted for papers in journal databases, including PubMed, Embase, CINAHL, Scopus, and IEEE Xplore, between 2000 and 2022. Papers were screened according to predetermined inclusion and exclusion criteria, and reference lists were reviewed for additional paper inclusion. Three authors appraised the methodology of papers independently, then collaboratively to synthesize the evidence.

RESULTS

Six publications were included in the scoping review. The design and methodology ranged widely from pilot studies to a comparative effectiveness trial. Older participants in the studies reported a variety of musculoskeletal conditions. Delivery of the mHealth pain self-management interventions incorporated mobile devices, such as a smartphone or tablet. Most mHealth-delivered interventions were multicomponent and incorporated elements of in-person and telephone access to an interventionist. The findings suggested mHealth interventions may reduce pain intensity; however, pain interference and other pain-related conditions did not have a statistically significant reduction.

CONCLUSIONS

Research that has explored mHealth for pain self-management is beginning to move beyond feasibility. The few experimental studies conducted in older adults are heterogeneous, and the interventions are mostly multicomponent. It is premature to conclude the interventions’ significant effect on pain or pain-related symptoms. As technology continues to integrate into health care, more experimental research is warranted to examine the efficacy of mHealth interventions on a variety of pain outcomes in older adults.
Research and Practice of Innovation and Entrepreneurship Education in Petroleum Colleges Based on OBE Concept
Authors: Jiangao ZHANG , Huan LIANG , Hongtao DENG , Jiayi ZHANG
Published: May 2023

Deepening the research on the topic of “Research on the current situation of innovation and entrepreneurship practice among college students and analysis of response strategies” is of great value to the healthy operation and coordinated development of college students, higher education institutions, the whole society and the country, and plays a positive role in creating the excellent trend of mass entrepreneurship and innovation in the whole society. It plays a great role in promoting the optimization and adjustment of the economic and industrial structure, the rationalization of market resources, the increase of employment opportunities, the improvement of employment quality and the improvement of people’s living standards. At the same time, combined with the support of sociology and related innovation and entrepreneurship theories, the study from a new perspective provides a theoretical basis and practical guidance for university students to participate in innovation and entrepreneurship activities, and provides certain reference value for further in-depth study of social innovation and entrepreneurship development work.
DESIGN AND DEVELOPMENT OF PHYDROMOD APPLICATION USING SCIENCE PROCESS SKILLS APPROACH AT IBNU SINA UNIVERSITY
Authors:   Universitas Ibnu Sina, Meldra Delia , Setyabudhi Albertus L ,   Universitas Ibnu Sina, Mardiansyah Yopi ,   Institut Teknologi Batam
Published: June 2023

The purpose of this research is to develop a Phydromod product which is an android-based physics practicum e-module. This is because the physics practice courses at the Faculty of Engineering, Ibnu Sina University (UIS) has a fundamental obstacle, namely there is no fixed module that guides all students like other universities and high student mobility. The method used in this study is the Research and Development (RnD) method by following the ADDIE model for module and Waterfall for aplication. Phydromod was developed using the Java program, which will later contain practicum modules for each meeting. The subjects in this study were 1C Regular Industrial Engineering students. The evaluation was carried out using two questionnaires which were analyzed using a Likert scale, which consisted of a module validation questionnaire and the phydromod application. The results of this study are in the form of module products with a module validation value of 88 and 88.2% Phydromod implementation.
Air Quality Forecasting Using Deep Learning Framework
Authors: Mahadik Sakshi
Published: June 2023

Abstract: Air quality is a crucial environmental factor that affects human health and well-being. Accurate forecasting of air quality can aid in mitigating the adverse effects of air pollution. In this research paper, we propose a deep learning-based approach for air quality forecasting. We utilize Convolutional Neural Networks (CNN) and Bidirectional Long Short-Term Memory (BILSTM) models to capture spatial and temporal dependencies in air quality data. The existing system is analyzed, and its limitations are identified. Our proposed solution overcomes these limitations by incorporating deep learning techniques. Experimental results demonstrate the effectiveness of our approach in forecasting air quality, providing valuable insights for environmental management and public health initiatives.
Air Writing and Recognition System
Authors: Bamanikar Prof. Ashvini
Published: May 2023

Abstract: A revolutionary method that enables users to write in the air using hand gestures and precisely recognizes finger movement is the air writing and recognition system using the MediaPipe module. A new method that enables users to write in the air using hand movements while AWS Textract accurately translates and converts the written language is to use AWS Textract for air writing detection and recognition. It uses machine learning techniques to examine how the hand landmarks move over time and recognize various gestures. The system is an effective and user-friendly solution for jobs requiring text input and air writing due to its real-time tracking and precise recognition capabilities.
AR Indoor Navigation System
Authors: Jess Revathy , Manoj Sneha , J Sravana A , K Prof. Savitha K
Published: June 2023

Abstract: Nowadays, the field of abstract- augmented reality is starting to boom. In business, education, and now in the navigation of enormous multi-complexes, augmented reality is utilized. With its many capabilities and fewer hardware requirements at the same time, augmented reality makes work simpler and more exciting. When utilized for navigation, augmented reality can give a person additional directions from where they are now to where they want to go in an unknown environment. The purpose ofour research is to investigate every technology that is practical for indoor navigation and to propose a simple prototype as a remedy. Augmented Reality employs its inherent properties toassess a person's position and provide the appropriate navigational guidance in the case of indoor navigation.
Teachers’ Professional Self-Efficacy for Collaboration: A Comparison Between European Countries
Authors:   University of Latvia, Kampmane Kristine , Geske Andrejs , Ozola Antra
Published: June 2023

Since the understanding of non-cognitive skills and their importance have grown, it becomes more and more significant to measure their impact on different areas of professional life. It has been researched that not only individual teacher’s professional self-efficacy, but also collective self-efficacy has a significant impact on both the teachers’ self-efficacy and students’ achievement. The purpose of this study is to select a set of factors that correlate with teachers’ professional self-efficacy and to analyse if teachers’ professional self-efficacy has an impact on teachers’ cooperation with colleagues and students. Latvian, Lithuanian, Estonian, Danish, Norwegian, Swedish, and Finnish data from the OECD TALIS 2018 teacher questionnaires were used. o analyse which factors correlate with teachers’ professional self-efficacy, the authors of this article selected such variables as the type of school, the type of urbanization, the number of special education students in the class, full time or partial time employment, professional development courses and the professional development at university level. The authors found that there were no significant correlations between the type of school, the type of urbanization, and the number of special education students in the classroom, but there was a significant correlation between professional development courses and the professional development during the university study period. The teachers who worked full time job were more self-efficient than others. To study the impact of self-efficacy on collaboration, the authors of this article selected variables that represented teacher – student collaboration and teacher – teacher collaboration. The professional self-efficacy scale was partitioned into four efficacy levels and each level was analysed with answers from each variable. The group comparison and the linear regression analysis showed that teachers with higher self-efficacy levels cooperated more and better with students and colleagues. Thus, this research adds supplementary evidence to studies showing the importance of professional self-efficacy development.
Stress Resilience and Coping Mechanisms of the Regional University Students in the 2nd Wave of COVID-19 Pandemic
Authors:   Daugavpils University, Iliško Dzintra , Badjanova Jeļena , Raščevskis Vitālijs
Published: June 2023

Stress is a typical reaction to internal or external factors that are disrupting equilibrium in one’s life or daily routine. In this study stress in considered as a multifaceted factor resulting either in good or bad outcomes depending on one’s mindset and context. The context of the study is the second wave of the COVID-19 pandemic when University students were forced to continue to pursue a remote learning experience and had to adapt to new learning norms and circumstances. The focus of the study is on how the pandemic and the remote learning have influenced students’ stress resilience and how it correlates with their coping strategies. As for the theoretical framework authors have chosen a biopsychosocial (BPS) model where a challenge or a threat is related to the way we think about situational demands and find coping resources that are available to interact with the stressful situation. Stress resilience in this article is discussed as an effective comping mechanism in order to regain the equilibrium. The aim of the study is to explore the factors causing stress of bachelor level students in one of the regional universities of Latvia and their coping mechanisms with stress during the 2nd wave of pandemics. The design of the study is a complementary use of quantitative and qualitative methodology that allows in-depth exploration of students’ experience during the second wave of pandemic. The methods or instruments: The authors chose students’ diary as a means of reporting events that are causing stress in students’ life as well as a questionnaire with the students who are engaged in diverse programmes during the second wave of the pandemic (n=196 students) and factors determining their stress resilience.