bluuebunny/crossref_metadata_2025 huggingface dataset:
NAPREDNA JTAG (JOINT TEST ACTION GROUP) KONTROLNA PLOČA ZA VERIFIKOVANJE ŠTAMPANIH PLOČA U PROIZVODNOM PROCESU
Authors: Đozlija Đorđe
Published: September 2022

U ovom radu je opisan proces dizajniranja i fabrikacije kontrolne JTAG štampane ploče. Kroz ovaj rad se može vidjeti kako zapravo teče proizvodni proces dizajniranja jedne štampane ploče.
PRIMENA „LEAN CONSTRUCTION“ U GRAĐEVINARSTVU – PRIMER PREFABRI-KOVANE ARMIRANO BETONSKE HALE OD PROIZVODNJE DO MONTAŽE
Authors: Pongrašić Nikola
Published: September 2022

U okviru ovog rada predstavljen je princip optimizacije resursa sa aspekta gubitaka koji se javljaju u toku izvođenja radova. Kao osnova za izradu rada korišćen je „LEAN CONSTRUCTION“ princip, a konkretno na primeru procesa od proizvodnje armirano betonskih elemenata montažne hale, preko procesa transporta elemenata montažne konstrukcije od proizvodnog pogona do gradilišta, do ugradnje elemenata na gradilištu. Svaki od navedenih kriterijuma gubitaka u osnovnom dokumentu „LEAN CONSTRUCTION“ obrađen je u svakoj od faza izvršavanja radnji i na taj način predstavljeni su načini optimizacije svakog od procesa u izvođenju radova.
УПРАВЉАЊЕ ПРОЈЕКТИМА У ГРАЂЕВИНАРСТВУ У ЗАВИСНОСТИ ОД ТИПА УГОВОРА
Authors: Вујачић Глигорије
Published: September 2022

У раду је описан принцип управ­љања пројектима у грађевинарству где су обухваћене почетне фазе сваког пројекта, улога учесника у пројекту као и само уговарање пројеката које није јединствено у грађевинарству a од ког даље зависи начин управљања и, свакако, реализација пројеката. Анализирани су принципи управљања пројектима који су уговорени по јединици мере као и они пројекти који су уговорени са одредбом „кључ у руке“, дати су конкретни примери за оба случаја и изведени су закључци.
ISTRAŽIVANJE MOGUĆNOSTI IZRADE ŠTAMPAJUĆIH ELEMENATA FLEKSO ŠTAMPARSKE FORME POMOĆU DLP 3D TEHNOLOGIJE
Authors: Vićentić Danica , Dedijer Sandra
Published: September 2022

Flekso tehnika štampe beleži najveću inovativno-tehnološku ekspanziju i imajući na umu njen značaj za grafičku industriju i s druge strane tehnologiju 3D štampanja, koja trenutno cveta, javila se potreba za testiranjem mogućnosti kreiranja fleksografske štamparske ploče 3D tehnologijom štampanja. U okviru ovog rada ispitivana je mogućnost izrade flekso štamparske forme, odgovarajućih debljina, sa zadovoljavajućom reproduk­cijom štampajućih elemenata u vidu linija i tačaka odgova­rajućih širina, odnosno prečnika, postupkom DLP (Direct Light Processing) 3D tehonologije štampe. Na osnovu mikroskopskuh snimaka reprodukovanih štampajućih elemenata forme a potom merenja prečnika, odnosno širina štampajućih elemenata u odgovarajućem softveru i analize njihove tačnosti reprodukcije, ukazano je na potencijalne mogućnosti izrade kao i nedostatke.
УНАПРЕЂEЊЕ КВАЛИТЕТА ПРОЦЕСА ИЗРАДЕ КАРТОНСКE АМБАЛАЖE ЗА ТЕЧНУ ХРАНУ
Authors: Радисављевић Иван , Ђурђевић Стефан , Новаковић Драгољуб
Published: September 2022

У овом раду су приказане теоријске основе графичке амбалаже, процес производње амбалаже, рачунарске припреме и репродукције боја. Експериментални део обухвата осврт на апликације за графичку припрему, уређаје за контролу квалитета репродукције боја, уређаје за израду пробног отиска и сам процес унапређења и контроле квалитета репродукције боја.
Faktor-Faktor Yang Mempengaruhi Kinerja Keuangan Pada Perusahaan Manufaktur
Authors: Thio Lie Sha Arvielda,
Published: September 2022

This study aims to obtain empirical evidence of the effect of sales growth, firm debt, liquidity and firm size on financial performance. The sample used in this study is a manufacturing companies listed on the Indonesia Stock Exchange (IDX) in 2017-2019, and obtained as many as 82 data. This study uses purposive sampling and uses Eviews 12 in processing the data. The results showed that firm debt has a negative and significant effect on financial performance. While sales growth, liquidity and firm size has insignificant effect on financial performance, and has a positive and insignificant effect on financial performance The implication of this research is that a company requires high quality management so as to assist the company in improving its financial performance so that the company can compete and maintain its sustainability.
Pengaruh Modal Kerja, Likuiditas, Struktur Modal dan Ukuran Perusahaan Terhadap Profitabilitas
Authors: Lukman Surjadi Erica Septhasari,
Published: September 2022

The purpose of this study was to obtain empirical evidence whether the independent of working capital, liquidity, capital structure and firm size affect profitability in manufacturing companies listed in Indonesian Stock Exchange during the period of 2016-2019. This study uses secondary data and processes using Software Eviews 12.0 SV. The data was obtained from the financial statements that were published by Indonesian Stock Exchange. The number of samples used 85 companies in manufacturing companies were selected using in the purposive sampling method with data count 255 during three period. This study uses descriptive statictical analysis, classic assumption test, and multiple linear regression test. The results of study show that working capital, liquidity and capital structure did not significantly influence profitability. On the other hand, company size has a significant negative affect on profitability.
Faktor-Faktor Yang Mempengaruhi Firm Value Sebelum Dan Di Masa Covid-19
Authors: Yanti Jessica Lavena,
Published: September 2022

The purpose of this study is to examine the variables that affect firm value as well as to examine the differences in firm value before and during the COVID-19 period. The research methods used are multiple linear regression analysis and different test with IBM SPSS. The sampling technique used is purposive sampling which resulted in 47 manufacturing companies listed on the IDX. The results of the regression test before the COVID-19 period showed that profitability and dividend policy have an effect on firm value, while liquidity, leverage and firm size have no effect on firm value. The results of the regression test during the COVID-19 period showed that profitability has an effect on firm value, while liquidity, leverage, firm size and dividend policy have no effect on firm value. The result of the different test showed that there is no difference in the average of firm value before and during the COVID-19 period.
Pengaruh COVID-19, Nilai Kurs dan Efek Bulan Ramadan terhadap Pengembalian Pasar Saham
Authors: Nurainun Bangun Cesilia Hong,
Published: September 2022

This study aims to examine the effect of COVID-19, exchange rate and Ramadan month effect on stock market returns in consumer goods industry firm listed on the Indonesia Stock Exchange (IDX) in 2020. The sampling method used in this study is purposive sampling with predetermined criteria. The result of this study shows that COVID-19 that is proxied by daily death case, exchange rate and Ramadan month effect have no effect on stock market returns. COVID-19 that is proxied by daily recovered case have positive effect on stock market returns.
Faktor-Faktor Penentu Kebijakan Hutang: Studi pada Perusahaan Barang Konsumsi di Indonesia
Authors: Nurainun Bangun Delicia Zora Damara,
Published: September 2022

This study aims to examined the effect of asset stucture, liquidity and non-debt tax shields to debt policy on consumer goods companies listed on Indonesia stock exchange since 2018-2020. This study method used was descriptive quantitative and 49 selected companies observated by using the purposive sampling method. Data processing in this study was carried out using the eviews 12 application. The results of this study showed that all independent variables asset stucture, liquidity and non-debt tax shields have a significant affect on debt policy.
Pengaruh Profitabilitas, Firm Size, Leverage, Dan Net Working Capital Terhadap Cash Holding
Authors: Vidyarto Nugroho Karen Darmawan,
Published: September 2022

This research was conducted with the aim of obtaining empirical evidence of the effect of Profitability, firm size, leverage, and Net Working Capital on Cash Holding. Manufacturing companies listed on the Indonesia Stock Exchange (IDX) for the 2017-2019 period are the subjects that will be used in this study. The test was carried out on 258 samples of data from 86 samples of manufacturing companies that had been processed using the purposive sampling technique. EViews ver 12.0 program will be used for data processing. The research conducted shows that profitability and Firm Size do not have a significant positive effect on Cash Holding, Leverage has a significant positive effect on Cash Holding, and Net Working Capital has a significant positive effect on Cash Holding.
Analisis Faktor-Faktor Yang Mempengaruhi Struktur Modal Perusahaan Makanan dan Minuman
Authors: Augustpaosa Nariman Kenny Sukardi,
Published: September 2022

This study aims to determine the effect of company size, profitability (ROA), Liquidity, Net Profit Margin and Total Asset Turnover on the capital structure of food and beverage companies listed on the Indonesia Stock Exchange for the 2018-2020 research period. The population of the food and beverage sector is 30 companies. The sampling technique used in this research is the purposive sampling method. There are 18 registered food and beverage companies from 2018 to 2020 that meet the criteria to be sampled. The research data used was secondary data which was tested using E-views version 11. The data analysis method used was the multiple regression method. The results of this study indicate that firm size and total asset turnover have a positive effect on the capital structure. Liquidity has a significant negative effect on the capital structure, while profitability and net profit margins have no effect on the capital structure.
Pengaruh Akrual, Leverage, Dan Arus Kas Operasi Terhadap Persistensi Laba Dengan Book Tax Differences Sebagai Variabel Moderasi
Authors: Veronika  , Herlin Tundjung Setijaningsih
Published: September 2022

This research aims to analyze the effect of accruals, leverage, and operating cash on earnings persistence by using the book tax difference as moderation in manufacturing companies listed on the Indonesia Stock Exchange during 2018-2020. The sample was selected by purposive sampling method as many as 40 companies with a total of 120 data for three years. The data technique uses multiple regression analysis and is processed with Eviews 12.0 and Microsoft Excel 2013. The results of this study indicate that: 1) Accruals, leverage, and operating cash flow have significant effect on earnings persistence; 2) The difference in book tax does not strengthen the effect of accruals, leverage, and operating cash flows on earnings persistence; 3) The difference in book tax does strengthen the effect of operating cash flows on earnings persistence.
Analisis Faktor-Faktor yang Mempengaruhi Praktik Income Smoothing
Authors: Giovanni Regina Gondokusumo  , Merry Susanti
Published: September 2022

This research aims to explain the effect of board independence, profitability, leverage, firm size and managerial ownership on income smoothing of manufacturing companies listed in Indonesia Stock Exchange over the period of 2017-2020. This research used 42 companies as its samples that were selected by purposive sampling techniques with 168 data in total for four years and were analyzed using logistic regression through EViews 10 as the medium for the data processing. The data which were used in this research are secondary data obtained from the financial statements. Sample companies in this research were classified using Eckel Index into smoothed companies and non-smoothed companies. The results conclude that profitability and managerial ownership have negative impacts on the practice of income smoothing. On the other hand, board independence, leverage and firm size have no impacts on the practice of income smoothing.
Faktor-Faktor Yang Memengaruhi Intellectual Capital Disclosure Pada Perusahaan Manufaktur
Authors: Cynthia Tatang  , Sukrisno Agoes  , Henny Wirianata
Published: September 2022

The purpose of this research was to examine the effect of profitability, leverage, firm size, institutional ownership, and independent commissioner on intellectual capital disclosure in manufacturing companies listed on the Indonesia Stock Exchange in the period 2018-2020. This research used 68 manufacturing companies as samples after being selected by purposive sampling method. The data was processed using the EViews 12 SV program. The result of this research showed that firm size and institutional ownership had positive effect on intellectual capital disclosure, while profitability, leverage, and independent commissioner had no effect on intellectual capital disclosure.
Phytochemical Screening, Antioxidant, Antidiabetic and Anticancer Activities of Elaeocarpus variabilis Fruit
Authors: Balamurugan Venkatachalam , Sridhivya Manikandan , Dharani Ramachandran , Selvakumar Subramaniam , Vasanth Krishnan
Published: September 2022

This study focused on the determination of secondary metabolites to an evaluation of the biological activity of Elaeocarpus variabilis Zmarzty fruit extract, an endemic medicinal plant. Their total Phenolic, tannin, flavonoids, alkaloids and saponins contents were quantified and their antioxidant activity, determined by DPPH, total antioxidant, ABTS, FRAP and Fe2+ chelating activity. The ethyl acetate extract exhibited the highest radical scavenging activity. The most relevant contents in total phenolics (Gallic Acid Equivalent mg/g), tannin (Gallic Acid Equivalent mg/g), total flavonoids (Rutin equivalent mg/g), total alkaloids (Quinine equivalent mg/g), and total saponin (Diosgenin equivalent mg/g) were observed. Significant correlations were established between antioxidant activity and secondary metabolites. Though the in vitro anti-diabetic activity was carried out using -amylase and -glucosidase inhibition, this indicates that the absorption and digestion of carbohydrates would probably reduce the blood glucose levels and hence help the management of type-2 diabetes. The ethyl acetate extract exhibited the potential of anticancer activity on human HT-29 colon cancer cell line IC50 values (30.0 ± 1.0) the valuable activity that compared to doxorubicin (17.0 ± 0.5). While this is the first study concerning extract from E. variabilis, our findings highlighted the richness’ in flavonoids of those extracts and their amazing potential as a source of antioxidant, anti-inflammatory, anti-diabetic, and anticancer agents.
Biochar Amendments for Reducing Nitrate Leaching from Soils of Different Textural Classes in the Nigerian Savanna
Authors: Solomon Rejoice Ibrahim
Published: September 2022

This study was carried out with the aim of assessing the effectiveness of four biochar materials; in reducing nitrate leaching from soils of three different textural classes in the Nigerian Savanna region. Soil samples (0-20 cm depth) were collected from three different soil types and three different locations each in the Nigerian Savanna using stratified random sampling. Two hundred and fifty (250) g of soil samples were amended with 0, 2.5, 5, 7.5 and 10 tonha-1 of Maize cob biochar (MCB), rice husk biochar (RHB), cow dung biochar (CDB) and poultry litter biochar (PLB) and were subjected to laboratory leaching experiment. Sixty (60) ml of nutrient solutions containing 300 mgl-1 nitrate using ammonium nitrate (NH4NO3) was applied to each of the laboratory biochar-incubated soil columns to study biochar effect on nutrients retention and transport. The experiment was laid in a Randomize Complete Block Design (RCBD) replicated three times. Leachates were collected and nitrate concentration was determined using a dual beam UV/VIS spectrophotometer. The data collected were analysed using the Generalized Linear Model (GLM) procedure and the means were separated using Tukey’s honest significant difference (SAS version 9.4). Results obtained revealed that there were no significant differences among the biochar treatments on nitrate leaching from Clay loam. However, highest nitrate leaching from Loamy soil of 30.53% was recorded by the application of 2.5 tonha-1 PLB and was significantly different from the application of 2.5 and 5-ton ha-1 RHB and 5-ton ha-1 MCB. Similarly, highest nitrate leaching from Sandy loam of 32.18 % was recorded by the application of 5-ton ha-1 MCB and was significantly higher than 5.94, 2.40 and 7.12 % recorded by the application of 2.5 and 5-ton ha-1 RHB and 7.5 tonha-1 CDB respectively. Therefore, application of 2.5, 5-ton ha-1 RHB and 7.5 tonha-1 CDB can effectively reduce nitrate leaching from Sandy loam. While 2.5, 5, 7.5 tonha-1 CDB and 2. 5 and 5 tonha-1 RHB reduced nitrate leaching from Loamy soils.
Determination of Expression Level of Genes Associated with Anthocyanin Biosynthesis in Some Myrtle (Myrtus communis L) Genotypes
Authors: Açar Emine , Aka Kaçar Yıldız
Published: September 2022

The Myrtle plant (Myrtus communis L.) is a plant species of the Myrtaceae family and a member of the maquis community, which naturally spreads in Mediterranean regions. Being resistant to arid conditions, the ecological distribution areas of the myrtle plant have been allowed to expand. The myrtle plant has been used of medicinal and aromatic plants, having interesting and beautiful flowers, and rich nutrient content of the fruit in terms of valuable phytochemicals, in particular, the nutritional content of its fruits and valuable metabolites have allowed the myrtle plant to be among the healthier foods. Antioxidant activity, which neutralizes reactive oxygen species (ROS), which causes many medical problems, is one of the most important features of the myrtle plant. Investigation of the biosynthesis of anthocyanin, which leads to antioxidant activity, and determination of the biosynthesis in different tissues and genotypes is important, especially in the development of production activities. Furthermore, this study aimed to investigate the anthocyanin biosynthesis in different genotypes with white and black fruits and various tissues of genotypes. For this purpose, the expression levels of CHS, CHI, F3H and PAL genes, which are involved in the anthocyanin biosynthesis pathway, were determined by qRT-PCR. In the study, it was determined that there was an increase in the level of genes related to the biosynthesis of anthocyanin in the leaf and fruit tissues of the genotype with white fruits. It was determined that the expression level of genes related to the biosynthesis of anthocyanin was observed to be higher in the leaf and fruit tissues of the genotype with black fruits, and the highest gene expression level was found in black fruits. It was observed that anthocyanin biosynthesis was synthesized in different tissues of the plant, and anthocyanin biosynthesis was higher in fruits compared to leaves.
Heavy Metal Toxicity in Plants: An Overview on Tolerance Mechanisms and Management Strategies
Authors: Yavaş İlkay , Ali Shafaqat , Abbas Zohaib , Hussain Saddam
Published: September 2022

Heavy metals are one of the factors that pollute the environment and significantly affect soil fertility, plant physiology, development, and productivity. The tolerance of plants to toxicity depends on the species and tissue, element type, and duration of exposure to stress. Some special signal molecules such as nitric oxide (NO), hydrogen peroxide (H2O2), beneficial ions, hyperaccumulating plants, stress hormones, nanoparticles, organic compounds, and microbial applications can be recommended to alleviate the stress effects caused by toxic heavy metals in plants. Induction of other promising techniques like seed priming, active involvement of plant growth regulator, use of osmoprotectants, successful plant microbes’ crosstalk and recent utilization of nanoparticles are worth using strategies in mitigation of heavy metal stress in plants. These practices effectively regulate the activities of antioxidant enzymes for the alleviation of stress in plants, creditably improving the plant tolerance via preserving cell homeostasis and amending the adversative effects of heavy metal stress in plants. These inventive strategies offer an enriched understanding of how to boost crop productivity under heavy metal stress in order to decrease the risk to global food security.
Multivariate Analysis of Land Use Impact on Soil Water Content and Some Physicochemical Properties of an Alfisol
Authors: Echebiri Joy Chiamaka , Awe Gabriel Oladele
Published: September 2022

Land use could impact soil properties and processes in varying degrees. Therefore, the impact of different land use systems on soil water status and its relationship with some physiochemical properties was studied at the Teaching and Research Farm, Ekiti State University, Ado Ekiti, Nigeria. The land use types included native forest (NF); Paddock (P); Oil palm plantation (OP); Teak (TK); new yam plot (NY) and yam plot under fallow (YF). Structure and disturbed surface soils (0 - 15 cm) samples were taken at three (3) locations in each land use type. Soil water content (SWC) significantly varied among the different land use types, with oil palm plantation storing the highest amount of water. The results also showed significant differences in soil bulk density, organic carbon, porosity, texture and hydraulic conductivity among the land use types. SWC associated positively and significantly with organic matter, silt content and silt + clay. The association between SWC and pH and silt/clay were positive but weak while particle density, bulk density and sand content showed negative and significant association. The principal component regression (PCR) showed a highly significant, positive relationship between SWC and the principal components of other physicochemical properties. Cluster analysis showed that SWC is highly related and linked to OM, Bd, Pd, Pt and silt/clay. The results implied that conversion to paddock and continuous cultivation led to depletion in soil water, physical and chemical properties, whereas cultivation of tree crops conserved these soil properties better. Therefore, establishment of tree crop and conservative soil management practices are suggested to prevent agricultural lands from degradation in areas with soils under similar conditions.
Effects of Pre-Starter Feeds Prepared Using Different Sugar Sources on Performance, Carcass Parameters, Internal Organ Development, Intestinal Development and Microbial Load in Broilers
Authors: Kutay Harun , Kutlu Hasan Rüştü
Published: September 2022

The purpose of the study is to determine the effects of pre-starter feed prepared using different sugar sources on the performance, carcass parameters, internal organs and intestinal development, microbial load in broilers. In total, 360 newly hatched chicks divided into 4 treatment groups with 5 replicates. 18 chicks with similar live weights (9 male, 9 female) were used for each replicate. Control or pre-starter feeds (containing %14 saccharose, %14 dextrose, or %7 saccharose+ %7 dextrose) were used for the feeding of the groups. For the feeding of the control group, standard chick starter feed was used for the first 5 days; for the treatment groups, the pre-starter feeds prepared were used. For the rest of the trial period, all groups were subjected to standard feeding. A significant difference was observed among groups with regards to live weight gain and feed conversion rate during the first four weeks of the study; however, this effect disappeared over the last week. In addition, it was determined that any differences observed with regards to carcass parameters other than hot and cold carcass weights, internal organ development aside from proventriculus, intestinal development and microbial load were not significant. It was concluded that the pre-starter feed prepared with saccharose and/or dextrose did not show the expected effect
Recovery of cyanosis after esophageal intubation in a neonate with tracheal agenesis: a case report
Authors: Çelik Hasan Tolga , Akın Mustafa Şenol , Bozkaya Davut , Yalçın Emel Şule , Süslü Ahmet Emre , Haliloğlu Mithat , Güçer Kadri Şafak , Yurdakök Murat
Published: September 2022

Background. Tracheal agenesis (TA) is a rare congenital defect that consists of a complete or partial absence of the trachea below the larynx, with or without tracheoesophageal fistula (TEF). It is a severe congenital defect with a very high mortality rate. The recommended surgical approach is esophageal ligation and gastrostomy. Despite the progress in reconstructive surgical techniques, the outcome of the anomaly is still very poor. We described a case of TA with a TEF in a female newborn with a hemivertebra, single ventricle, single atrioventricular valve, single atrium, and cardiac left isomerization.
Case. The patient, who was born at 37 weeks of age, was diagnosed with imaging methods, as the cyanosis did not improve despite being intubated many times in the delivery room; the cyanosis improved after esophageal intubation. Despite all life support treatment, the patient died on the fourth day of life. At autopsy, tracheal agenesis was diagnosed.
Conclusions. In newborns who cannot be intubated in the delivery room or whose lungs cannot be ventilated despite being intubated and whose cyanosis cannot be corrected, tracheal agenesis should be considered and ventilation with esophageal intubation should also be tried.
Development of preschool refugee children living under temporary protection status
Authors: Ayas Meltem Tuğçe , Özmert Elif N , Başer Duygu A , Karabulut Erdem , Cankurtaran Mustafa
Published: September 2022

Background. The conflict in Syria following the anti-regime demonstrations that started in March 2011 created one of the greatest humanitarian crises. The United Nations High Commissioner for Refugees (UNHCR) reports that refugee and resettlement experiences can influence the critical stages of intellectual, social, emotional and physical development of children. There is a lack of sufficient information about the prevalence of developmental delay in forcibly displaced children. In this study, we aimed to describe the impact of the Syrian crisis on the development of children after resettlement, factors that are associated with developmental problems and domains in which developmental delays are more likely to occur.
Methods. Refugee children (n=60) between the ages of 18-72 months admitted to the Yenimahalle Community Health Center Immigrant Health Unit to receive primary health care services between 1 November 2018- 1 March 2019 were included in this study. The control group included 60 Turkish children between 18-72 months admitted to the İsmail Ulucan Family Health Center which is in the same building. Developmental assessments were conducted by the researchers using the Denver II Developmental Screening Test (DDST-II). Sociodemographic characteristics of the child, family and caregivers as well as risk factors related to development were collected using a questionnaire. The interviews with refugee families were conducted with an interpreter.
Results. Developmental delay was more frequent in refugee children compared to Turkish children. The DDST-II were normal in 82.1%, questionable in 10.7% and abnormal in 7.1% of Turkish children; in the study group, 22.2% of the patients were found to be normal, 33.3% were questionable and 44.4% were abnormal. The differences were statistically significant (p < 0.05). Multiple logistic regression analysis revealed that, being a forcibly displaced refugee was the single significant risk factor for developmental delay alone. In the DDST II subdomain analysis, it was seen that high monthly income reduces the risk of caution-delay in personal-social domain. It was found that birth weight below 2500 g increased the risk of caution-delay in the fine-motor and gross-motor domain and being a forcibly displaced refugee and consanguinity increased the risk of caution -delay in the language domain.
Conclusions. This study showed that being a forcibly displaced refugee was the most important risk factor for developmental delay. We emphasized the importance of surveillance and screening development in these highrisk children as well as early intervention services.
Optic neuritis in CD59 deficiency: an extremely rare presentation
Authors: Günay Çağatay , Yardım Elvan , Yaşar Elif , Hız-Kurul Ayse Semra , Uzan Gamze Sarıkaya , Öztürk Taylan , Yaman Aylin , Yiş Uluç
Published: September 2022

Background. CD59 is the principal cell inhibitor of complement membrane attack on cells. Stroke, peripheral neuropathy, and recurrent central nervous system attacks have been reported in patients with inherited CD59 deficiency. In this paper, we report a patient with CD59 deficiency associated with two attacks of demyelinating peripheral neuropathy and the third attack as an isolated optic neuritis.
Case. An 8-month-old girl whose sibling died at 12th month of age with recurrent weakness episodes responsive to intravenous immune globulin treatment, presented with weakness in legs and poor sucking. Weakness episodes with neurogenic electromyography suggested CD59 deficiency. Immunophenotypic analysis with flow cytometry showed CD59 deficiency. Sanger sequencing of CD59 gene revealed a homozygous c146delA (p.Asp49Valfs*32) mutation. First two attacks were treated with intravenous immunoglobulin therapy without any sequalae. Third attack was an isolated optic neuritis which could not be explained by any other entity. The patient had no response to intravenous immunoglobulin but benefited from pulse steroid therapy. Eculizumab was started every two weeks in order to prevent possible advanced attacks and to reduce their severity.
Conclusion. Although it is a rarely reported disease, better recognition of CD59 deficiency by pediatric neurologists is necessary because it is curable. In addition to different presentations reported, optic neuritis may also be a manifestation of CD59 deficiency.
A rare case of hypomyelinating leukodystrophy-14 benefiting from ketogenic diet therapy
Authors: Ünalp Aycan , Köse Melis , Karaoğlu Pakize , Güzin Yiğithan , Yılmaz Ünsal
Published: September 2022

Background. Hypomyelinating leukodystrophy-14 (HLD14) is a rarely seen neurodevelopmental disease caused by homozygous pathogenic ubiquitin-fold modifier 1 gene variants. The disease has an autosomal recessive inheritance. All patients with this condition reported to date have drug-resistant epilepsy. The posttranslational modification of proteins with ubiquitin fold modifier 1 is defective in these patients and is thought to be responsible for severe neurodevelopmental problems. There is no previous report on the effectiveness of the ketogenic diet in the treatment of drug-resistant epileptic seizures in this disease. Therefore, we present a pediatric case diagnosed with HLD14 and whose drug-resistant epileptic seizures were controlled by ketogenic diet therapy.
Case. The patient was a three-year-old male with drug-resistant epilepsy and developmental delay. His brain magnetic resonance imaging revealed cerebellar atrophy, periventricular white matter hypomyelination, and ventricular enlargement. Whole-exome sequencing analysis identified a homozygous pathogenic variant in the ubiquitin-fold modifier 1 gene on chromosome 13q13. Ketogenic diet therapy was initiated for his drug-resistant seizures and subsequently reduced seizure frequency by more than 75%. The patient is still on ketogenic diet therapy.
Conclusions. Ketogenic diet therapy may be beneficial for seizure control in HLD14 patients with drug-resistant seizures.
Association between serum vitamin A, D and E status and respiratory distress syndrome in preterm infants - a propensity score matching analysis
Authors: Zhang Yinying
Published: September 2022

Background. This study aimed to assess whether the serum levels of vitamin A, vitamin D and vitamin E are associated with respiratory distress syndrome (RDS) in preterm infants.
Methods. This retrospective research included 179 neonates born before 35 weeks of gestation in Jiaxing Maternity and Child Health Care Hospital from January 2020 to December 2020. Depending on whether or not they had RDS, participants were classified into the RDS group (59 neonates) and the control group (120 neonates). The 1:1 propensity score matching (PSM) analysis was performed to balance the baseline confounding factors and then the groups were compared in terms of serum vitamin levels and RDS morbidity.
Results. A total of 34 pairs of preterm infants were involved after PSM. There were significant differences in vitamin D level (12.13 (8.44-17.85) ng/mL vs. 16.84 (10.75-25.83) ng/mL), vitamin D deficiency rate (85.3% vs. 55.9%), as well as vitamin A level (134.91 (105.01-156.74) ng/mL vs. 152.46 (120.06-200.00) ng/mL) in the two groups. However, the vitamin A deficiency rate, vitamin E status, as well as vitamin E deficiency rate did not differ significantly between the two groups. Logistic analysis showed that a low level of vitamin D was an independent risk factor for RDS in preterm neonates (OR 0.917, 95%CI 0.851-0.989).
Conclusions. Low serum vitamin D levels may contribute to the development of RDS in preterm infants, but no significant effect of serum vitamin A and vitamin E levels was found.
Assessment of auditory functions in patients with hepatic glycogen storage diseases
Authors: Şanlı Merve Emecen , Ezgü Fatih , Okur İlyas , İnci Aslı , Kılıç Ayşe , Özsaydı Ekin , Gündüz Bülent , Tutar Hakan , Gökay Nuriye Yıldırım , Tümer Leyla
Published: September 2022

Background. Hepatic glycogen storage diseases are a group of diseases manifesting mainly with hypoglycemia and hepatomegaly. The patients require frequent daytime and nocturnal feedings. Hypoglycemia may cause sensorineural hearing loss and nocturnal feeding is a risk factor for the development of gastroesophageal reflux that may cause chronic otitis media and hearing loss consequently. We aimed to determine the prevalence and characteristics of hearing loss in hepatic glycogen storage diseases.
Methods. A total of 24 patients with hepatic glycogen storage disease (15 glycogen storage disease type I and 9 non type I) and 24 age/sex matched healthy controls were enrolled in the study. Pure tone audiometer, immitansmetry, acoustic reflex measurement, otoacoustic emission test (OAE) and auditory brainstem response (ABR) tests were applied to all participants.
Results. Hearing loss was determined in 17/24 patients (12 glycogen storage disease type I and 5 non type I) with pure tone audiometer. Interpretation of all the findings revealed a total of 8 patients had conductive and 9 had mixed hearing loss. All parameters were significantly different than the control group.
Conclusions. This is the first study to comprehensively assess the auditory functions of patients with hepatic glycogen storage disease. Audiological findings determined a significantly increased prevalence of conductive/ mixed type hearing loss in the patient group which is a new finding in the literature. Further studies with extended patient numbers are required to enlighten the underlying pathophysiology.
Is vasoactive-inotropic score associated with early lactate clearance a predictive outcome of children with septic shock?
Authors: Çeleğen Mehmet , Çeleğen Kübra
Published: September 2022

Background. The main goal of septic shock therapy is to keep hemodynamic parameters in the normal range for adequate tissue perfusion. Persistent lactic acidemia has increased mortality. We evaluate the association between vasoactive-inotropic score (VIS) and lactate clearance (LC) to predict mortality of septic shock in children.
Methods. This is a retrospective study of consecutive septic shock in children admitted to the pediatric intensive care unit. Vital signs, laboratory values, and VIS were obtained at admission and the 6th hour of hospitalization. LC was calculated at the 6th hour. The associations between LC and VIS were evaluated using univariate and multivariate analysis. Receiver operating characteristic analysis was used to describe the cutoff values of LC and VIS.
Results. Eighty-two children, age 82.3 ± 59.8 months, were included, with an overall lactate clearance of 29 ± 26%, and a mortality rate of 25.6%. The optimal cutoff value of LC was 20%. Children with LC ≥ 20% compared with LC < 20% had a lower VIS [(21.41 ± 8.36) vs. (27.48 ± 10.11) (p: 0.009)]. In multivariate comparison, PELOD score and VIS were significantly associated with 6-hour lactate clearance < 20% but VIS at 6 hours had a significant inverse relationship with LC < 20%. The cutoff for VIS was ≥ 16.2 for prognosticating the 6-hour LC and the high VIS group had a significantly lower LC and higher mortality ratio than the low VIS group.
Conclusions. High VIS was associated with lower lactate clearance and has been described as a predictor of greater mortality among septic shock in children.
Private Extensionists’ Role in an Effort to Achieve SDGs through Peri-Urban Community Empowerment
Authors: Sumardjo  , Firmansyah Adi , Dharmawan Leonard
Published: September 2022

Infrastructure development has forced the transformation of rural farming communities to peri-urban communities and impacted community unreadiness. In Presidential Decree No. 59/2017, the Sustainable Development Goals (SDGs) have been set as indicators of Indonesia's development. Private extensionists have a fundamental role in community empowerment as the implementation of Corporate Social Responsibility (CSR) in large companies. This research has built an alternative concept of private extensionists in the SDGs. The research objectives are to analyze the role of private extensionists in community empowerment through self-social engineering and to analyze the impact of community empowerment on the SDGs' achievement. The research method used is participatory action research supported by a cybernetic approach: participant-observer, triangulation techniques, and focus group discussion (FGD). The results showed that private extensionists' implementing the concept of self-social engineering effectively empowered the community. This effectiveness occurs by placing the community as the subject of creative social energy in empowerment. This is in line with the application of the participatory communication paradigm and dialogue, which causes a communication convergence between participants. The peri-urban community empowerment approach in organic farming development positively impacts the achievement of SDGs.
Gambaran Castelli’s Risk Index-1 pada Pasien Sindrom Koroner Akut di RSUP Dr. M. Djamil Padang
Authors: Sabebegen Eka Musmita , Yaswir Rismawati , Efrida Efrida
Published: September 2022

Atherogenic dyslipidemia is one of the risk factors for the acute coronary syndrome (ACS). Castelli's risk index-1 (CRI-1) is one of which risk markers for ACS. Castelli's risk index-1 is the ratio of total cholesterol and HDL cholesterol. The test is cheap and easy to do in the hospital setting. Objectives: To described CRI-1 in ACS patients in Dr. M. Djamil Padang Hospital. Methods: This descriptive study was carried out in the central laboratory and the CardioVascular Care Unit (CVCU) of Dr. M. Djamil Hospital Padang from September 2017 to September 2018. The population was all ACS patients who have been diagnosed by the clinician. The samples were part of the population that meet the inclusion and exclusion criteria. Colorimetric enzymatic method using automated clinical chemistry used to measure total cholesterol and HDL cholesterol. Results: This study used CRI-1> 4. Data were presented descriptively in a frequency distribution table. Seventy ACS patients were consisting of 50 (71.43%) males and 20 (28.57%) females, with a median age of 60.1 (8.93) years old. The median total cholesterol and HDL cholesterol levels were 178.66 (46.84) mg / dL respectively and 35.71 (10.86) mg / dL. CRI-1 mean is 5.43 (2.27). 81.43% CRI-1 subject results were more than four. Conclusion: The low levels of HDL cholesterol and within normal median total cholesterol level made CRI-1 value increased.Keywords: Acute coronary syndrome, Castelli’s risk index-1
Comparison of autograft and implant cranioplasty in pediatrics: A meta-analysis
Authors: Aprianto Dirga Rachmad , Parenrengi Muhammad Arifin , Utomo Budi , Al Fauzi Asra , Subagio Eko Agus , Suryawan Ahmad
Published: September 2022

Background:

Cranioplasty in pediatrics is quite challenging and intricated. The ideal material for it is still debatable until now due to the limited study comparing autologous and implant grafts. This meta-analytic study was conducted to evaluate the risk of infection and revision in pediatric patients after autograft and implant cranioplasty.

Methods:

A systematic review and meta-analysis were performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. A thorough literature search was conducted on PubMed, Cochrane, Scopus, and ScienceDirect database. Articles published from 2000 to 2021 were selected systematically using PRISMA based on the predetermined eligibility criteria. The relevant data were, then, analyzed and discussed.

Results:

A total of four publications investigating the outcome of autograft and implant cranioplasty were included and reviewed. Postoperative infection and revision rate after 126 cranioplasty procedures (both autograft or implant) from 119 patients below 21 years during time frame of study were analyzed. This meta-analysis study showed that the rate of infection and revision after cranioplasty were not different between the autograft and implant groups.

Conclusion:

Autograft and implant cranioplasty have no significant difference in postoperatively infection and revision rate. This study showed that cranioplasty using implant is a plausible option in pediatric patients with cranial defects, depending on the patients’ condition due to similar outcome with autograft cranioplasty. Further studies with larger population and more specific details are necessary to determine the comparison of autograft and implant material in cranioplasty procedure.
Spontaneous regression of solid-cystic vestibular schwannoma: A case report
Authors: Dahamou Mohamed , Elfarissi Mohammed Alamine , Lhamlili Mohammed , Mehfoud Ibrahim , Khoulali Mohamed , Oulali Noureddine , Moufid Fayçal
Published: September 2022

Background:

Vestibular schwannomas (VSs) are one of the most common tumors of the cerebellopontine angle and internal meatus, the evolution of this type of tumors is defined as unpredictable, it can enlarge or present a spontaneous regression as described in rare cases.

Case Description:

We report the case of a 50-year-old woman who presented with a large right full cystic VS revealed by a balance disorder associated with deafness in the right ear which spontaneously regressed. The patient was lost to follow-up for 3 years, the symptomatology improved, and the tumor clearly regressed without any surgical treatment.

Conclusion:

Spontaneous regression of solid-cystic VS is possible but rare, it can be part of conservative treatment, which requires regular follow-up.
Advanced frailty assessment tool predicts successful awake craniotomy in a 92-year-old patient: A case report
Authors: Cole Kyril L. , Varela Samantha , Rumalla Kavelin , Kazim Syed Faraz , Rebbe Ryan W. , Carvajal Michael , SantaCruz Karen S. , McKee Rohini , Willman Cheryl , Schmidt Meic H. , Bowers Christian A.
Published: September 2022

Background:

The awake craniotomy (AC) procedure allows for safe and maximal resection of brain tumors from highly eloquent regions. However, geriatric patients are often viewed as poor candidates for AC due to age and medical comorbidities. Frailty assessments gauge physiological reserve for surgery and are valuable tools for preoperative decision-making. Here, we present a novel case illustrating how frailty scoring enabled an elderly but otherwise healthy female to undergo successful AC for tumor resection.

Case Description:

A 92-year-old right-handed female with history of hypertension and basal cell skin cancer presented with a 1-month history of progressive aphasia and was found to have a ring-enhancing left frontoparietal mass abutting the rolandic cortex concerning for malignant neoplasm. Frailty scoring with the recalibrated risk analysis index (RAI-C) tool revealed a score of 30 (of 81) indicating low surgical risk. The patient and family were counseled appropriately that, despite advanced chronological age, a low frailty score predicts favorable surgical outcomes. The patient underwent left-sided AC for resection of tumor and experienced immediate improvement of speech intraoperatively. After surgery, the patient was neurologically intact and had an unremarkable postoperative course with significant improvements from preoperatively baseline at follow-up.

Conclusion:

To the best of our knowledge, this case represents the oldest patient to undergo successful AC for brain tumor resection. Nonfrail patients over 90 years of age with the proper indications may tolerate cranial surgery. Frailty scoring is a powerful tool for preoperative risk assessment in the geriatric neurosurgery population.
Correlation of pelvic incidence and pelvic parameters in lumbar spondylolisthesis
Authors: Gadkari Alok , Ghodke Aashish , Jha Amrit
Published: September 2022

Background:

Pelvic incidence (PI) and pelvic parameters (PP) regulate the sagittal alignment of the spine and the pelvis in normal populations. Correlation of PI even more so than PP with lumbar spondylolisthesis (LS) would be useful for surgical planning.

Methods:

This study included 45 patients randomly selected with LS. They were divided into two groups; Group S had LS and Group C had low back pain due to other causes. All patients received lateral standing radiographs of the spine and pelvis. Based on these films, we measured the sacral slope, pelvic tilt, PI, and lumbar lordosis (LL).

Results:

There were significant correlations between the PI and the sacral slope, pelvic tilt, and LL in Group S (P < 0.05). The majority of patients with LS presented with middle (60%) followed by high PIs (26.67%). Low PI was observed among just 13.33% patients with LS.

Conclusion:

Changes in spinopelvic parameters reflecting pelvic compensatory mechanisms differ depending on the extent of PI in patients with LS. In short, higher PI values correlated with more significant degrees of degenerative LS in Group S population.
NETOSIS PARAMETERS IN PATIENTS WITH SELECTIVE IGA DEFICIENCY
Authors:   Gomel State Medical University, Gomel, Belarus, Prokopovich S. S. , Novikova I. A. ,   Gomel State Medical University, Gomel, Belarus
Published: September 2022

Objective. To study NETosis parameters in patients with selective immunoglobulin A deficiency. Material and methods. We studied the features of NETosis in peripheral blood of 46 patients (21 males and 25 females, mean age 37±12.7 years) with a confirmed diagnosis of selective immunoglobulin A deficiency. Results. Аctivation of NETosis (NET30SP, NET30ST, NET150SP and NET150ST, р<0.001) was found in patients with selective IgA deficiency relative to the comparison group. The maximum degree of increase in leukocyte NETosis in patients was observed during short-term incubation of cells (NET30SP, NET30ST). The relationship between the level of NETosis and apoptosis of neutrophils has been revealed. The patients with a simultaneous activation of NETosis and superoxide anion production by neutrophils showed a higher incidence of combined clinical manifestations compared to patients with an isolated increase of NETosis (χ2=9.19; р=0.002). Conclusion. This study demonstrated that in patients with selective immunoglobulin A deficiency during remission of infectious inflammatory diseases, the ability of blood neutrophils to form extracellular networks in combination with the activation of other manifestations of neutrophils reactivity – superoxide anion-producing function and apoptosis – is increased.