bluuebunny/crossref_metadata_2025 huggingface dataset:
Nephrotic Syndrome as an Extramuscular Manifestation of Anti-EJ Antibody-Positive Dermatomyositis: A Case Report and Review of the Literature
Authors: Tsubouchi Syoko , Mizuuchi Takahiro , Yamamoto Yusuke , Fujimori Daiki , Ishii Kayo , Tago Mayu , Kato Eri , Mori Hiroaki , Hayashi Haeru , Tahara Koichiro , Sawada Tetsuji
Published: September 2022

Renal involvement is underestimated as an extramuscular manifestation of dermatomyositis (DM). Here, we describe a 67-year-old woman with anti-glycyl-transfer ribonucleic acid synthetase (anti-EJ) antibody and anti-ribonucleoprotein antibody-positive DM complicated by systemic sclerosis, who developed nephrotic syndrome concurrently with the exacerbation of DM, as indicated by incremental serum creatine kinase levels, high-intensity lesions on muscle magnetic resonance imaging, and active interstitial pneumonitis on chest computed tomography. Renal biopsy revealed the presence of immune-deposition in the glomerulus by immunofluorescence. To our knowledge, this is the first report describing the coexistence of anti-EJ antibody-positive DM and nephrotic syndrome. More reports of similar cases are warranted to substantiate the association.
A Study on Early Warning of Financial Indicators of Listed Companies Based on Random Forest
Authors: Wang Zilin
Published: September 2022

Financial crises can have a negative impact on business operations, and in serious cases, they directly affect the survival and growth of a company. Therefore, the study of financial early warning based on financial indicators is particularly important. However, there are still some shortcomings in the current research on financial early warning, for example, it still evaluates the scoring method or only uses a single model to participate in the construction of financial early warning algorithm. In view of the above problems, this study will mainly use the random forest method combined with the decision tree algorithm to study the financial early warning problem of listed companies in China. Firstly, this paper uses the literature review method to analyse the relevant literature and generate the financial indicator system for this study. Subsequently, by collecting the financial data of A‐share listed companies in China from 2013 to 2018 as the research object, the importance ranking of financial indicators was generated by using random forest modelling after data preprocessing. On this basis, CART decision tree modelling was applied to generate financial indicator early warning determination rules and analyse them. The results of the study show the importance ranking of financial indicators and the six financial warning rules based on the CART decision tree. Through this research, it is expected to achieve the objective of providing early warning for the risk of financial crisis and to provide constructive financial warning solutions for relevant stakeholders.
Climate Change and Environmental Influence on Prevalence of Visceral Leishmaniasis in West Pokot County, Kenya
Authors: Abdullahi Bulle , Mutiso Joshua , Maloba Fredrick , Macharia John , Riongoita Mark , Gicheru Michael
Published: September 2022

Kala-azar is a parasitic disease caused by Leishmania species transmitted by sand fly. In Kenya, kala-azar is endemic in thirty subcounties spread over in eleven counties in the arid zones. Climate change-influenced seasonal weather variability and environmental alterations remain important determinants of many vector-borne diseases. The present study focused on climate change and environmental influence on kala-azar in West Pokot. A descriptive cross-sectional and retrospective research design was adapted. Study area was purposively selected. Locations were randomly selected, and households were systematically selected. Three hundred sixty-three household questionnaires, eleven key informant interviews, and five focus group discussions were undertaken. Secondary data were obtained from Kacheliba subcounty hospital records. Statistical Package for the Social Sciences version 24 was used to analyze quantitative data while qualitative data were analyzed to establish connection for interpretation. Kala-azar cases have been on the rise on aggregate and surge towards the end of dry season and just after the rains. Significant environmental factors included the presence of seasonal rain water pathways and rock piles around houses (AOR = 4.7; 95% CI = (2.3-9.6),

p
<
0.05

), presence of acacia trees in and around homesteads (AOR = 8.5; 95% CI = (2.5-28.6),

p
<
0.05

), presence of anthills around the homesteads (AOR = 5.2; 95% CI = (1.2-23.4),

p
<
0.05

), and presence of animal shed within compound (AOR = 2.8; 95% CI = (0.96-8),

p
<
0.05

). Climate change-induced seasonal weather variability, increased temperature and reduced precipitation as well as environmental alterations influence kala-azar occurrence in West Pokot. Community sensitization on disease prevalence, clearing of vector predilection sites, and improving community environmental risk perception are imperative to promote prevention.
First Report on Intensity Bioassays for Pyrethroid Resistance in Anopheles culicifacies s.l in District Dindori of Madhya Pradesh State and Districts Kanker and Bastar of Chhattisgarh State, India
Authors: Mishra Ashok K. , Singh Mrigendra P. , Das Aparup , Raghavendra Kamaraju
Published: September 2022

Background. The major malaria vector in India is Anopheles culicifacies, and indoor residual spraying (IRS) and distribution of long-lasting insecticidal nets (LLINs) are the two main vector control measures in the national program. This species has shown resistance to dichlorodiphenyltrichloroethane (DDT), malathion, and synthetic pyrethroids (SP). The study was carried out in three districts, that is, Dindori of Madhya Pradesh and Kanker and Bastar from Chhattisgarh state to know the range of resistance phenotypes and to assess the strength of resistance in An. culicifacies. Methods. An. culicifacies collected from the field was tested to determine the susceptibility status to the discriminating concentration (DC) of different insecticides, that is, DDT 4.0%, malathion 5.0%, alphacypermethrin 0.05%, and deltamethrin 0.05% following the World Health Organization (WHO) procedures. Further, intensity bioassays of the resistant An. culicifacies to 1X discriminating concentration (DC) of alphacypermethrin and deltamethrin were conducted by exposing 5X and 10X concentrations of 1X DC. Results are interpreted as per the WHO criterion. Results. The overall result of susceptibility status in An. culicifacies in districts Dindori, Kanker, and Bastar revealed confirmed resistance to DDT, malathion, alphacypermethrin, and deltamethrin registering mortality of 15% (10–20%), 70% (65–75%), 78.6% (77–82.5%), and 87% (84.8–91.3%), respectively. Further, in district Dindori and Baster, the intensity bioassay test at 5X DC of alphacypermethrin and deltamethrin revealed 99% and 100%, respectively, while in district Kanker, the species registered moderate resistance with 92.5% and 95% mortality, respectively, in 5X DC of alphacypermethrin and deltamethrin. However, in 10X DC, the An. culicifacies was susceptible to both pyrethroids (100%) in district Kanker. Conclusion. The results of the intensity bioassay tests with SP-resistant An. culicifacies suggested no change of insecticide is required in the ongoing intervention. However, regular monitoring of insecticide susceptibility and intensity bioassays in malaria vectors in view of continued use of these interventions may increase resistance and for implementing effective vector management strategies.
Antiviral Activity against Respiratory Syncytial Virus of Polysaccharide from Jerusalem Artichoke (Helianthus tuberosus L.)
Authors: Wan Xinhuan , Liu Zihao , Wang Yuliang , Yin Yiming , Cai Xiaoqing , Gao Lina , Wang Qi , Li Ying , Zhou Changzheng
Published: September 2022

Jerusalem artichoke (Helianthus tuberosus L.) polysaccharide (JAP) is a chain polysaccharide composed of D‐fructose connected by β (1‐2) glycosidic bonds, which is a kind of inulin. This study evaluated the anti‐respiratory syncytial virus (RSV) activity of JAP in vivo and in vitro. To investigate its antiviral activity, an MTT assay, q‐PCR, enzyme‐linked immunosorbent assay (ELISA), and lung histological observation were performed. The results showed that JAP showed anti‐RSV activity in vitro with a half maximal inhibitory concentration (IC50) of approximately 29.15 μg/mL. In vivo results suggested that JAP could effectively inhibit RSV proliferation in the lungs and improve lung tissue lesions in RSV‐infected mice. Additionally, JAP could also reduce the expression of TLR3 and TLR4 in the lungs, increase serum anti‐inflammatory factors IL‐4 levels, and reduce pro‐inflammatory factors TNF‐α and TNF‐β levels, which may be related to its anti‐RSV activity. This study provides a new approach to anti‐RSV therapy and enriches the potential applications of JAP.
Container Quay Crane Structural Response under Trolley Traveling
Authors: Hu Xiong , Dong Kai , Zheng Pei , Sun Zhiwei , Mu Sen
Published: September 2022

Structural response of quay crane should take more attention with the growth of worldwide logistics demand and quay crane size. This paper analyzes the response mechanism of the metallic structure of the quay crane induced by trolley traveling. An on-site test has been conducted. The time domain of crane girder acceleration signal shows that the main influence of the trolley traveling on crane structure is the high-frequency impact passing through the hinge point. The spectrum shows the main frequency of structure vertical vibration and impact vibration. Single girder model and theoretical derivation reveal that the vertical displacement response is quasistatic. A refined numerical model of the whole crane structure is established. The interaction between the trolley and the girder is realized by S-M contact method. The calculated results are basically consistent with the measured signal. The acceleration result indicates the same information as on-site test such that the structural acceleration response of in-service crane is affected by trolley in high-frequency band. The displacement results in three directions of 10 points on the girder show that the trolley traveling has significant effect on the vertical displacement. The lateral displacement shows the eccentric loading condition of girder. The displacement spectrum indicates that the trolley has little dynamic effect on displacement response of crane structure. The response can be treated as quasistatic.
Untargeted Metabolite Profiling of Specialty Rice Grains Using Gas Chromatography Mass Spectrometry
Authors: Kambale Rohit , Raveendran M. , Ramalingam J.
Published: September 2022

With-ever increasing demand food grains for the increasing population, it has also increased the importance of quality rice with nutritional and therapeutic properties. The quality of rice includes nutritional value, therapeutic properties, and further generation of aroma. Initial studies on sensory analysis using potassium hydroxide (1.7% KOH) identified the presence of a distinct aroma of the traditional rice cultivar Chakhao Amubi in comparison with other aromatic rice varieties were conducted. The metabolomic profiling of aromatic rice grains Chakhao Amubi, Pusa Basmati 1, and nonaromatic rice, Improved White Ponni was attempted to use gas chromatography-mass spectrometry (GC-MS). A total of fifty volatile aromatic compounds, including aromatic hydrocarbons, alkanes, alkenes, ketones, and aromatic aldehydes, have been identified. Detected compounds include six crucial volatile i.e., pentanal, hexanal, 2-pentylfuran, pyridine, (Z)-7-Decenal, and Mesitylene for distinct flavor and presence of aroma in Chakhao Amubi. The findings showed a distinct difference in the metabolic profile of Chakhao Amubi compared to Pusa Basmati 1 and Improved White Ponni. Thus, this study paved the way for a new understanding of the aromatic aspects of traditional rice germplasm and its utilization in rice breeding programs to improve the aroma, therapeutic, and nutritional characteristics of rice.
Metastatic Carcinoma of the Breast Presenting as Gingival Swelling in the Maxilla: A Case Report
Authors: Sadasivan Arun , Rakul Nambiar K. , Mathew Deepu George , Koshi Elizabeth , Ramesh Roshni , Benny Ashna Mariya
Published: September 2022

Background. Metastatic cancers in the oral cavity are usually very rare and are usually an indication of widespread malignancy. In some cases, oral metastasis was found to be the first presentation of distant site tumours. Even though oral metastatic lesions may be found anywhere in the oral cavity, they commonly present in the posterior areas of the jaw bones. Among the soft tissues, the gingiva is the most common site. The presence of inflammation in the gingiva and the role of periodontal microbiota are suggested to play a role in the attraction of metastatic cells. The purpose of this case report is to present a rare case of metastatic breast carcinoma presenting as a gingival enlargement in the maxillary anterior region. Case Presentation. A 37-year-old female patient who underwent modified radical mastectomy for invasive ductal breast carcinoma reported to the dental clinic with a gingival enlargement in the anterior maxillary region. Clinical and radiographic examination showed a rapidly enlarging gingival lesion with destruction of the underlying bone. A wide excision of the entire lesion was done. Histopathological and immunohistochemical (IHC) evaluations were suggestive of infiltrating poorly differentiated adenocarcinoma. Conclusion. This case report presents a metastatic oral lesion in the maxillary anterior region of the primary breast cancer site. The young age of patient and an uncommon site of metastatic lesion are the striking features of this case. We would like to highlight the importance of a thorough clinical, radiological, and histological evaluation of any gingival swelling as it could be a metastatic lesion. IHC staining helps in the diagnosis of the primary site of metastatic carcinomas. An early diagnosis and intervention could reduce the morbidity of the lesion and improve the survival rate.
KLHDC8A Expression in Association with Macrophage Infiltration and Oxidative Stress Predicts Unfavorable Prognosis for Glioma
Authors: Cheng Tong , Xu Manyu , Zhang Hui , Lu Bing , Zhang Xiaojing , Wang Ziheng , Huang Jianfei
Published: September 2022

Background. The tumor immune microenvironment (TME) is associated with cancer progression and immune escape. Although KLHDC8A has been reported in glioma in vitro, the expression and clinical significance of this gene in clinical samples are unknown. Methods. The Cancer Genome Atlas and Chinese Glioma Genome Atlas databases were used to evaluate the mRNA expression level of KLHDC8A and its significance in the glioma TME. Tissue microarray-based multiple immunohistochemical staining was conducted to determine KLHDC8A protein levels and characterize the immune signature of tumor-infiltrating immune cells in gliomas. Results. Tumor cells and tumor-associated macrophages expressed KLHDC8A. The expression of KLHDC8A was higher in glioma tissues than in normal brain tissues and was associated with patient clinical characteristics. Gliomas exhibited a high abundance of macrophages, neutrophils, regulatory T cells, and the immune checkpoint PD-L1, as well as high KLHDC8A expression. Cox regression analysis showed that KLHDC8A+CD68+ macrophages and KLHDC8A predicted unfavorable survival in patients with glioma. Finally, protein-protein interaction network analysis showed that the KLHDC8A expression was associated with hypoxia and oxidative stress. Conclusions. KLHDC8A is a potential marker for the clinical diagnosis of glioma. The immune characteristics of macrophages play a crucial role in predicting patients with glioma, providing a new avenue for targeted glioma therapy.
E3 Ubiquitin Ligase CHIP Inhibits the Interaction between Hsp90β and MAST1 to Repress Radiation Resistance in Non-Small-Cell Lung Cancer Stem Cells
Authors: Tan Bo , Zhang Jingwei , Wang Wen , Ma Haibo , Yang Yuanyuan
Published: September 2022

The radiation resistance of cancer stem cells poses a critical obstacle for management of non-small-cell lung cancer (NSCLC). It is interesting to note that E3 ubiquitin ligase CHIP is involved in radiation resistance and stemness phenotypes in NSCLC, while the downstream mechanisms remain elusive. Therefore, this study is aimed at exploring the possible molecular mechanism of E3 ubiquitin ligase CHIP in radiation resistance of NSCLC stem cells. Cancer and adjacent normal tissues of NSCLC patients were collected to determine expression of CHIP, Hsp90β, and MAST1. CD133+ cells were isolated from the NSCLC tissues and the lung cancer cell line A549 by flow cytometric sorting. Accordingly, downregulated CHIP and upregulated Hsp90β and MAST1 were observed in cancer tissues from NSCLC patients and in NSCLC stem cells. Sphere formation assay, colony formation assay, and flow cytometry were performed to examine self-renewal ability, survival, and apoptosis of NSCLC stem cells. An animal model of tumor xenograft was developed in nude mice to observe the tumorigenic ability and radiation resistance of NSCLC stem cells. CHIP overexpression was demonstrated to inhibit the NSCLC stem cell properties and radiation resistance in vitro and in vivo. Mechanistically, CHIP promoted MAST1 ubiquitination by blocking Hsp90β interaction with MAST1, thus inhibiting MAST1 protein stability. Furthermore, CHIP-mediated downregulation of MAST1 protein stability inhibited the NSCLC stem cell properties and radiation resistance. Collectively, CHIP promotes the ubiquitination of MAST1 by blocking the interaction of Hsp90β with MAST1, leading to decreased MAST1 protein stability, which suppressed NSCLC stem cell properties and radiation resistance.
Certain Geometric Properties of the Canonical Weierstrass Product of an Entire Function Associated with Conic Domains
Authors: Selvakumaran K. A. , Rajaguru P. , Purohit S. D. , Suthar D. L.
Published: September 2022

In this paper, we determine the radius of

λ

-uniform convexity,

λ

-starlikeness, and

α

-convexity of order

δ

for the Weierstrass canonical product of an entire function as a root having smallest modulus and argument

ϕ

of a functional equation. As special cases, we also determine the radius of

λ

-uniform convexity,

λ

-starlikeness, and

α

-convexity of order

δ

for the entire function

1
/
Γ

.
[Retracted] Impacts of Ultrasound‐Guided Nerve Block Combined with General Anesthesia with Laryngeal Mask on the Patients with Lower Extremity Fractures
Authors: Yang Xiaoxu , Bao Lei , Gong Xue , Zhong Hui
Published: September 2022

Objective. Surgical reduction is the leading approach to patients with lower extremity fractures. The options of anesthetic drugs during surgery are of great significance to postoperative recovery of patients. There is no consensus on the optimum anesthesia method for patients undergoing lower extremity fracture surgery. Our study is aimed at investigating the impacts of nerve block combined with general anesthesia on perioperative outcomes of the patients. Methods. In this retrospective study, 48 patients experienced general anesthesia only, and 42 patients received never block combined with general anesthesia. The perioperative hemodynamics was recorded, including mean arterial pressure (MAP), oxygen saturation of blood (SpO2), and heart rate (HR). Visual analogue scale (VAS) and Montreal Cognitive Assessment (MoCA) were carried out to evaluate postoperative pain and cognitive status. Furthermore, adverse reactions and recovery condition were observed between the patients receiving different anesthesia methods. Results. At 15 minutes and 30 minutes after anesthesia, as well as 5 minutes after surgery, significant lower MAP was observed in the patients treated with general anesthesia (83.04 ± 8.661, 79.17 ± 9.427, 86.58 ± 8.913) compared to those receiving never block combined with general anesthesia (90.43 ± 4.618, 88.74 ± 6.224, 92.21 ± 4.015) (P < 0.05), and compared with general anesthesia group (68.5 ± 7.05, 69.63 ± 7.956, 72.75 ± 8.446), the combined anesthesia group (73.52 ± 9.451, 74.17 ± 10.13, 77.62 ± 9.768) showed obvious higher HR (P < 0.05). No significant difference in SpO2 was found between the two groups at multiple time points (P > 0.05). As for the score of VAS and MoCA, remarkably lower VAS and higher MoCA at 6 h, 12 h and 24 h after surgery were presented in the combined anesthesia group compared to general anesthesia group (P < 0.05). At 24 h after surgery, the two groups showed normal cognitive function (26.33 ± 0.7244 vs. 28.55 ± 0.7392). Incidence of nausea and vomiting in the combined anesthesia group was lower than that of the general anesthesia group (P < 0.05). The time to out‐of‐bed activity and hospital stay were shorter in the combined anesthesia group compared with general anesthesia (P < 0.05). Conclusion. The application of never block combined with general anesthesia contributed to the stability of hemodynamics, alleviation of postoperative pain and cognitive impairment, along with decrease in adverse reactions and hospital stay in the patients with lower extremity fractures.
Application of ZnO Semiconductor Nanomaterial Ink in Packaging and Printing Design
Authors: Guo Changjian
Published: September 2022

In order to obtain a flat and clear packaging printing pattern, the author proposes a printing method based on ZnO semiconductor nanomaterial ink. The method uses zinc acetate dihydrate as raw material, ethylenediamine as a complexing agent, absolute ethanol as a solvent, and ethyl cellulose as an auxiliary agent to prepare particle-free ZnO functional ink. The ink was spin-coated on a glass substrate, cured at different temperatures on a heating plate for 30 min, and passed through an X-ray diffractometer, a field emission scanning electron microscope, an infrared spectrometer, a synchronous thermal analyzer, an ultraviolet-visible spectrophotometer, and a transmission electron microscopy were used to characterize the synthesized inks and the resulting films. Experiments show that the decomposition temperature of particle-free ZnO conductive ink is much lower than that of zinc acetate precursor; the film cured at 300°C for 30 min has a smooth surface, uniform particle size, good crystallinity, and transmittance of up to 80%. After inkjet printing on the PI flexible substrate, after curing at 300°C for 30 min, the pattern surface is smooth and clear, and the outline is clear. Conclusion. The printing method is based on ZnO semiconductor nanomaterial ink. It has good application prospects in packaging and printing design.
The Effects of Coconut Skim Milk and Coco-Dairy Milk Blend on the Nutritional Status of Schoolchildren
Authors: Agdeppa Imelda A. , Zamora Jezreel Ann T.
Published: September 2022

Milk feeding can be an effective response to the high prevalence of child undernutrition as it provides significant amounts of nutrients. This study investigated and compared the effects of coconut skim milk (CocoM) and coco-dairy milk blend (CDMB) to cow’s milk (CM) on improving the nutritional status of Filipino schoolchildren. The study followed a randomized, double-blind, controlled, parallel-group design. A total of 444 underweight/stunted schoolchildren aged 6.0–8.4 years old enrolled in Guadalupe Elementary School in Cebu City, Philippines, have participated. The participants were randomly allocated into three groups, that is, CocoM, CDMB, and CM, in which the milk products were packed in 200 ml color and number-coded bottles given for 95 days. The bottles were similar in form and shape, and the only differentiating factors were the code and color. Weight and height were measured using standard techniques. Nutritional indices such as weight-for-age z-score (WAZ), height-for-age z-score (HAZ), and BMI-for-age z-score (BAZ) were measured using the WHO Child Growth Standards (CGS), and the acceptability test was measured using the 5-point facial hedonic scale. The study found that the mean WAZ and BAZ had significantly increased from baseline to endpoint across all groups. Moreover, the prevalence of underweight has also significantly declined from baseline to endpoint in all groups, and the prevalence of stunting significantly declined from baseline to endpoint in the CocoM group only. Lastly, the three milk products were rated as generally acceptable. Overall, the findings indicate that coconut milk consumption could be beneficial for improving a child’s WAZ and BAZ, as well as improving the nutritional status of underweight and stunted schoolchildren. CocoM and CDMB were found to be equally beneficial to child nutrition as cow’s milk. Hence, the present study suggests that CocoM and CDMB could be also provided in school-based feeding programs with the aim of targeting child undernutrition.
A Cognitive Behavioral Computing Model Combined with DM’s Teaching Quality Improvement
Authors: Lei Bin
Published: September 2022

There are more and more ideas of applying data research science to replace theoretical research science, including monitoring and evaluation of school teaching quality. In order to distinguish different types of learners through knowledge and behavior performance, so as to better improve the teaching quality of teachers, a data mining model based on knowledge expression and calculation mode is provided. According to all the key cognitive and behavioral input parameters and cognitive and behavioral index factors, through the collection of artificial neural networks, sensitivity analysis, data mining, and classification regression trees, they are divided into three types of differences, so as to better adopt differentiation strategies for learners with different types. The experimental results also show that the behavior parameters are far more critical than the knowledge parameters. The research results show that the model is effective in supporting teachers' work in the education system.
Cardiovascular Disease Risk Factors, Musculoskeletal Health, Physical Fitness, and Occupational Performance in Firefighters: A Narrative Review
Authors: Ras Jaron , Smith Denise L. , Kengne Andre P. , Soteriades Elpidoforos E. , Leach Lloyd
Published: September 2022

Introduction. Firefighting is a strenuous occupation that requires firefighters to be in peak physical condition. However, many firefighters have risk factors for cardiovascular disease, impaired musculoskeletal health, and are not physically fit for duty, which all negatively impact their occupational performance. Therefore, the aim of this review is to determine the relationship between cardiovascular disease risk factors, musculoskeletal health, physical fitness, and occupational performance in firefighters. Methods. The electronic databases PubMed, SCOPUS, and Web of Science were searched online via the library portal of the University of the Western Cape. Publications and grey literature between the years 2000 to present were used. In total, 2607 articles were identified; after the removal of duplicates 1188 articles were then screened, and were excluded for not meeting initial screening criteria. The remaining 209 full‐text articles were screened based on the inclusion and exclusion criteria, where 163 articles were excluded. Only studies that were quantitative were included. This left 46 articles that were then finally included in the current narrative review. Results. The current literature indicated that significant relationships existed between cardiovascular risk factors, musculoskeletal health, physical fitness, and occupational performance. The results indicated firefighters who were aged, obese, physically inactive, cigarette smokers, and unfit were at the highest risk for cardiovascular and musculoskeletal health complications, and unsatisfactory occupational performance. Musculoskeletal health complications significantly affected occupational performance and work ability and were related to physical fitness of firefighters. Most cardiovascular risk factors were related to physical fitness, and all physical fitness parameters were related to occupational performance in firefighters. Conclusion. The overwhelming evidence in the current review established that physical fitness is related to occupational performance. However, the relationship between cardiovascular risk factors and musculoskeletal health in relation to occupational performance is less clear and still understudied. Significant gaps remain in the literature.
Logistics Supply Chain Management Mode of Chinese E-Commerce Enterprises under the Background of Big Data and Internet of Things
Authors: Han Xiao , Wang Jingyi
Published: September 2022

With the development of information technology, the logistics supply chain of Chinese E-commerce enterprises still has the problem of backward industrial model and low product quality. It is necessary to deeply integrate the logistics supply chain with big data and Internet technology and develop a logistics intelligent supply chain management model in order to meet the needs of Chinese E-commerce enterprises for logistics supply chain. The management mode of the logistics supply chain of Chinese E-commerce enterprises will show the development trend of diversification and simplification, standardization and normalization, and intelligence and efficiency in the future.
Qualitative Analysis of the Transmission Dynamics of Dengue with the Effect of Memory, Reinfection, and Vaccination
Authors: Tang Tao-Qian , Jan Rashid , Bonyah Ebenezer , Shah Zahir , Alzahrani Ebraheem
Published: September 2022

Dengue fever has a huge impact on people’s physical, social, and economic lives in low-income locations worldwide. Researchers use epidemic models to better understand the transmission patterns of dengue fever in order to recommend effective preventative measures and give data for vaccine and treatment development. We use fractional calculus to organise the transmission phenomena of dengue fever, including immunisation, reinfection, therapy, and asymptotic carriers. In addition, we focused our study on the dynamical behavior and qualitative approach of dengue infection. The existence and uniqueness of the solution of the suggested dengue dynamics are inspected through the fixed point theorems of Schaefer and Banach. The Ulam-Hyers stability of the suggested dengue model is established. To illustrate the contribution of the input factors on the system of dengue infection, the solution paths are studied using the Laplace Adomian decomposition approach. Furthermore, numerical simulations are used to show the effects of fractional-order, immunity loss, vaccination, asymptotic fraction, biting rate, and therapy. We have established that asymptomatic carriers, bite rates, and immunity loss rates are all important factors that might make controlling more challenging. The intensity of dengue fever may be controlled by reducing mosquito bite rates, whereas the asymptotic fraction is risky and can transmit the illness to noninfected regions. Vaccination, fractional order, index of memory, and medication can be employed as proper control parameters.
Experimental and Numerical Investigation of Energy Evolution Characteristic of Granite considering the Loading Rate Effect
Authors: Sun Feiyue , Fan Junqi , Guo Jiaqi , Liu Xiliang
Published: September 2022

In order to investigate the loading rate effect of energy evolution in granite, the indoor physical simulation test of single face fast unloading-three directions and five faces stress-vertical continuous loading under different loading rates was conducted using a new true triaxial rockbursttest system. The energy accumulation-dissipation-release characteristics in the process of rock deformation and failure were revealed. Based on the three-dimensional discrete element theory and the polycrystalline modeling technique (randomly generated Voronoi mineral grains), the entire process of rockburst inoculation-occurrence-development, as well as the energy evolution characteristics under true triaxial single face unloading conditions, were studied. The test results indicate that the energy transport and conversion of rock samples under different loading rates exhibit distinct stage characteristics. It can be divided into the initial energy accumulation stage, steady energy accumulation stage, rapid energy dissipation stage, and rapid energy release stage. With a rise in loading rate, the specimen in the process of energy accumulation is accompanied by energy dissipation, more external input energy, and elastic strain energy release amount into the kinetic energy of fragments, resulting in the rockburst phenomenon. As the loading rate increases, the elastic strain energy conversion rate (Ue/U) falls, while the dissipative energy conversion rate (Ud/U) increases. The higher the elastic strain energy conversion rate and the lower the dissipative energy conversion rate, the more serious the rockburst occurs. Numerical simulation results show that the entire process of rockburst inoculation-occurrence-development is successfully simulated using the crystal scale fine model (CSFM) considering the grain mineral composition. The ejection failure process can be divided into four stages, including grains ejection, rock spalling into plates, rock shearing into fragments, and rock fragments ejection. The relationships between the peak strength, elastic strain energy of rock samples, and loading rates are obtained, which is consistent with the laboratory test results. The high rate linear growth of kinetic energy evolution between the two inflection points can provide precursor information for rockburst prediction.
CDC20 May Serve as a Potential Biomarker-Based Risk Score System in Predicting the Prognosis of Patients with Hepatocellular Carcinoma
Authors: Peng Qiliu , Huang Hai , Zhu Chunling , Hou Qingqing , Wei Shangmou , Xiao Yi , Zhang Zhi , Sun Xing
Published: September 2022

Background. The specificity and sensitivity of hepatocellular carcinoma (HCC) diagnostic markers are limited, hindering the early diagnosis and treatment of HCC patients. Therefore, improving prognostic biomarkers for patients with HCC is urgently needed. Methods. HCC-related datasets were downloaded from the public databases. Differentially expressed genes (DEGs) between HCC and adjacent nontumor liver tissues were then identified. Moreover, the intersection of DEGs in four datasets (GSE138178, GSE77509, GSE84006, and TCGA) was used in the functional enrichment, and module genes were obtained by a coexpression network. Cox and Kaplan-Meier analyses were used to identify overall survival- (OS-) related genes from module genes.

Area
 
under
 
the
 
curve
 

AUC

>
0.9

of OS-related genes was then carried out in order to perform the protein-protein interaction network. The feature genes were identified by least absolute shrinkage and selection operator (LASSO). Furthermore, the hub gene was identified through the univariate Cox model, after which the correlation analysis between the hub gene and pathways was explored. Finally, infiltration in immune cell types in HCC was analyzed. Results. A total of 2,227 upregulated genes and 1,501 downregulated DEGs were obtained in all four datasets, which were mainly found to be involved in the cell cycle and retinol metabolism. Accordingly, 998 OS-related genes were screened to construct the LASSO model. Finally, 8 feature genes (BUB1, CCNB1, CCNB2, CCNA2, AURKB, CDC20, OIP5, and TTK) were obtained. CDC20 was shown to serve as a poor prognostic gene in HCC and was mainly involved in the cell cycle. Moreover, a positive correlation was noted between the high degree of infiltration with Th2 and CDC20. Conclusion. High expression of CDC20 predicted poor survival, as potential target in the treatment for HCC.
Studying the Anticancer Effects of Thymoquinone on Breast Cancer Cells through Natural Killer Cell Activity
Authors: Alshaibi Huda F. , Aldarmahi Nouf A. , Alkhattabi Nuha A. , Alsufiani Hadeil M. , Tarbiah Nesrin I.
Published: September 2022

Cancer immunotherapy is quickly growing and can now be viewed as the “fifth column” of cancer treatment. In addition, cancer immunotherapy has shown promising results with different kinds of cancers and may be used as a complementary therapy with various types of treatments. Thus, “immuno‐oncology” is showing astounding advantages. However, one of the main challenges that face this type of therapy is that cancer cells can evade immune system elimination through different mechanisms. Many studies were done to overcome this issue including adding immune stimulants to generate synergistic effects or by genetically modifying NK cells themselves to be stronger and more resistant. Nigella sativa, also known as black cumin, is a well‐known example of a widely applicable herbal medicine. It can effectively treat a variety of diseases, such as hypertension, diabetes, bronchitis, gastrointestinal upset, and cancer. The anticancer qualities of Nigella sativa appear to be mediated by an immune‐modulatory effect that stimulates human natural killer (NK) cells. These are a type of lymphocyte and first line of defense against pathogens. Objectives. In this study, we investigated the therapeutic effect of thymoquinone, a major component of Nigella sativa, on the cytotoxic pathways of NK cells. Methods. NK cells were cultured with breast cancer cell line Michigan Cancer Foundation‐7 (MCF‐7); and were treated with Thymoquinone. The cytotoxicity of NK cells on cancer cells was measured. The cultured media were then collected and measured via enzyme‐linked immunosorbent assay (ELISA) for concentrations of perforin, granzyme B and interferon‐α (IFN‐α). Results. The cytotoxic effect of NK cells on tumor cells was increased in the presence of thymoquinone, with an increased release of perforin, granzyme B, and IFN‐α. Conclusion. Thymoquinone promotes the cytotoxic activity of NK cells against breast cancer MCF‐7 cells.
Epidermal Growth Factor Receptor Inhibition Is Protective in Hyperoxia-Induced Lung Injury
Authors: Harris Zachary M. , Sun Ying , Joerns John , Clark Brian , Hu Buqu , Korde Asawari , Sharma Lokesh , Shin Hyeon Jun , Manning Edward P. , Placek Lindsey , Unutmaz Derya , Stanley Gail , Chun Hyung , Sauler Maor , Rajagopalan Govindarajan , Zhang Xuchen , Kang Min-Jong , Koff Jonathan L.
Published: September 2022

Aims. Studies have linked severe hyperoxia, or prolonged exposure to very high oxygen levels, with worse clinical outcomes. This study investigated the role of epidermal growth factor receptor (EGFR) in hyperoxia-induced lung injury at very high oxygen levels (>95%). Results. Effects of severe hyperoxia (100% oxygen) were studied in mice with genetically inhibited EGFR and wild-type littermates. Despite the established role of EGFR in lung repair, EGFR inhibition led to improved survival and reduced acute lung injury, which prompted an investigation into this protective mechanism. Endothelial EGFR genetic knockout did not confer protection. EGFR inhibition led to decreased levels of cleaved caspase-3 and poly (ADP-ribosyl) polymerase (PARP) and decreased terminal dUTP nick end labeling- (TUNEL-) positive staining in alveolar epithelial cells and reduced ERK activation, which suggested reduced apoptosis in vivo. EGFR inhibition decreased hyperoxia (95%)-induced apoptosis and ERK in murine alveolar epithelial cells in vitro, and CRISPR-mediated EGFR deletion reduced hyperoxia-induced apoptosis and ERK in human alveolar epithelial cells in vitro. Innovation. This work defines a protective role of EGFR inhibition to decrease apoptosis in lung injury induced by 100% oxygen. This further characterizes the complex role of EGFR in acute lung injury and outlines a novel hyperoxia-induced cell death pathway that warrants further study. Conclusion. In conditions of severe hyperoxia (>95% for >24 h), EGFR inhibition led to improved survival, decreased lung injury, and reduced cell death. These findings further elucidate the complex role of EGFR in acute lung injury.
Men and Women’s Alcohol Consumption by 4- to 8-Year-Olds: A Longitudinal Investigation of Gendered Drinking Norms
Authors: Cook Megan , Kuntsche Sandra , Smit Koen , Voogt Carmen , Pennay Amy , Kuntsche Emmanuel
Published: September 2022

Introduction: Evidence suggests an association between perceived alcohol-related norms and personal consumption. These perceptions develop over years of observation and exposure to alcohol, likely beginning in early childhood, and likely differing by sex. Understanding the early development of perceptions of drinking may provide insight into the development of gendered drinking practices. The aim of this study was to explore boys’ and girls’ perceptions about men and women’s alcohol consumption and whether and how these change over time as children age. Methods: 329 children (aged 4–6 years at baseline) completed the Dutch electronic Appropriate Beverage Task annually for three consecutive years (2015 [baseline], 2016, 2017). Regression models were used to examine whether perceptions of consumption varied as a function of the gender of the adult, the participants’ sex, and any changes over time. Results: In illustrated pictures, children perceived that men (39%) drank alcoholic beverages more often than women (24%). Men were perceived to drink alcohol more frequently than women at baseline and this difference increased with age. Girls were more likely to perceive men drinking at baseline (aged 4–6), but there were few sex differences by time point three (aged 6–8). Discussion/Conclusion: From a young age, children perceive that men drink more than women. These perceptions strengthen as children grow older, with young girls perceiving these gender differences at earlier ages than boys. Understanding children’s perceptions of gendered drinking norms and their development over time can enable targeted prevention efforts.
Proteomic Analysis of Effects of Spironolactone in Heart Failure With Preserved Ejection Fraction
Authors: Javaheri Ali , Diab Ahmed , Zhao Lei , Qian Chenao , Cohen Jordana B. , Zamani Payman , Kumar Anupam , Wang Zhaoqing , Ebert Christina , Maranville Joseph , Kvikstad Erika , Basso Michael , van Empel Vanessa , Richards A. Mark , Doughty Robert N. , Rietzschel Ernst , Kammerhoff Karl , Gogain Joseph , Schafer Peter , Seiffert Dietmar A. , Gordon David A. , Ramirez-Valle Francisco , Mann Douglas L. , Cappola Thomas P. , Chirinos Julio A.
Published: September 2022

Background:

The TOPCAT trial (Treatment of Preserved Cardiac Function Heart Failure With an Aldosterone Antagonist Trial) suggested clinical benefits of spironolactone treatment among patients with heart failure with preserved ejection fraction enrolled in the Americas. However, a comprehensive assessment of biologic pathways impacted by spironolactone therapy in heart failure with preserved ejection fraction has not been performed.

Methods:

We conducted aptamer-based proteomic analysis utilizing 5284 modified aptamers to 4928 unique proteins on plasma samples from TOPCAT participants from the Americas (n=164 subjects with paired samples at baseline and 1 year) to identify proteins and pathways impacted by spironolactone therapy in heart failure with preserved ejection fraction. Mean percentage change from baseline was calculated for each protein. Additionally, we conducted pathway analysis of proteins altered by spironolactone.

Results:

Spironolactone therapy was associated with proteome-wide significant changes in 7 proteins. Among these, CARD18 (caspase recruitment domain-containing protein 18), PKD2 (polycystin 2), and PSG2 (pregnancy-specific glycoprotein 2) were upregulated, whereas HGF (hepatic growth factor), PLTP (phospholipid transfer protein), IGF2R (insulin growth factor 2 receptor), and SWP70 (switch-associated protein 70) were downregulated. CARD18, a caspase-1 inhibitor, was the most upregulated protein by spironolactone (−0.5% with placebo versus +66.5% with spironolactone,
P
<0.0001). The top canonical pathways that were significantly associated with spironolactone were apelin signaling, stellate cell activation, glycoprotein 6 signaling, atherosclerosis signaling, liver X receptor activation, and farnesoid X receptor activation. Among the top pathways, collagens were a consistent theme that increased in patients receiving placebo but decreased in patients randomized to spironolactone.

Conclusions:

Proteomic analysis in the TOPCAT trial revealed proteins and pathways altered by spironolactone, including the caspase inhibitor CARD18 and multiple pathways that involved collagens. In addition to effects on fibrosis, our studies suggest potential antiapoptotic effects of spironolactone in heart failure with preserved ejection fraction, a hypothesis that merits further exploration.
Impact of Sex and Cardiovascular Risk Factors on Myocardial T1, Extracellular Volume Fraction, and T2 at 3 Tesla: Results From the Population-Based, Hamburg City Health Study
Authors: Cavus Ersin , Schneider Jan N. , Bei der Kellen Ramona , di Carluccio Eleonora , Ziegler Andreas , Tahir Enver , Bohnen Sebastian , Avanesov Maxim , Radunski Ulf K. , Chevalier Celeste , Jahnke Charlotte , Ojeda Francisco , Kirchhof Paulus , Blankenberg Stefan , Adam Gerhard , Lund Gunnar K. , Muellerleile Kai
Published: September 2022

Background:

Reliable reference intervals are crucial for clinical application of myocardial T1 and T2 mapping cardiovascular magnetic resonance imaging. This study evaluated the impact of sex and cardiovascular risk factors on myocardial T1, extracellular volume fraction (ECV), and T2 at 3T in the population-based HCHS (Hamburg City Health Study).

Methods:

The final study sample consisted of 1576 consecutive HCHS participants between 46 and 78 years without prevalent heart disease, including 1020 (67.3%) participants with hypertension and 110 (7.5%) with diabetes. T1 and T2 mapping were performed on a 3T scanner using 5b(3b)3b modified Look-Locker inversion recovery and T2 prepared, fast-low-angle shot sequence, respectively. Stepwise regression analyses were performed to identify variables with an independent impact on T1, ECV, and T2. Reference intervals were defined as the interval between the 2.5% and 97.5% quantiles.

Results:

Sex was the major independent influencing factor of myocardial native T1, ECV, and T2. Female patients had significantly higher upper limits of reference intervals for native T1 (1112–1261 versus 1079–1241 ms), ECV (23%–33% versus 22%–32%), and T2 (36–46 versus 35–45 ms) compared with male patients (all
P
<0.001). Cardiovascular risk factors, such as diabetes and hypertension, did not systematically affect native T1. There was an independent association of T2 by hypertension and, to a lesser degree, by left ventricular mass, heart rate (all
P
<0.001), and body mass index (
P
=0.001).

Conclusions:

Sex needs to be considered as the major, independent influencing factor for clinical application of myocardial T1, ECV, and T2 measurements. Consequently, sex-specific reference intervals should be used in clinical routine. Our findings suggest that there is no need for specific reference intervals for myocardial T1 and ECV measurements in individuals with cardiovascular risk factors. However, hypertension should be considered as an additional factor for clinical application of T2 measurements.

Registration:

URL:
https://www.clinicaltrials.gov
; Unique identifier: NCT03934957.