bluuebunny/crossref_metadata_2025 huggingface dataset:
On predicting an NBA game outcome from half-time statistics
Authors: Adam Christos , Pantatosakis Pavlos , Tsagris Michail
Published: July 2024

Predicting the outcome of an NBA game is a major concern for betting companies and individuals who are willing to bet. We attack this task by employing various advanced machine learning algorithms and techniques, utilizing simple half-time statistics from both teams. Data collected from 3 seasons, from 2020/21 up to 2022/23 were used to assess the predictive performance of the algorithms at two axes. For each season separately, apply the algorithms and estimate the outcomes of the games of the same season and secondly, apply the algorithms in one season and estimate the outcomes of the games in the next season. The results showed high levels of accuracy as measured by the area under the curve. The analysis was repeated after performing variable selection using a non-linear algorithm that selected the most important half-time statistics, while retaining the predictive performance at high levels of accuracy.
Unveiling the mechanism of amelioration of adjuvant-induced Rheumatoid Arthritis by Drynaria quercifolia rhizome extract using network pharmacology and gene expression-based studies.
Authors: Modak Debabrata , Ghosh Subhajit , Sarkar Sourav , Roy Sudipta K. , Chakraborty Ayan , Ray Arpita , Patel Chirag N. , Georrge John J. , Thakur Subarna , Bhattacharjee Soumen
Published: July 2024

Background: Fronds and rhizomes of Drynaria quercifolia have long been used to manage rheumatic pain. This study aimed to identify the effective components in Drynaria quercifolia methanol rhizome extract (DME) and their roles in alleviating Rheumatoid Arthritis (RA) using network-pharmacology, molecular docking, molecular-dynamics simulations, and gene expression validation.
Result: Gas chromatography–mass spectrometry (GC-MS) based screening identified 41 volatile phytocomponents from DME having drug-like potentiality. Database mining and network analyses revealed 117 potential targets of which 11 have been identified as core targets. In addition, the analysis of the herb-compound-target-pathway network investigation showed n-Hexadecanoic acid, octadecanoic acid, Ergost-5-en-3-ol, and (3 beta 24r) as potential key phytocomponents for the treatment of RA. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis indicated that key target genes were mostly enriched in the inflammatory response associated with multiple signalling pathways. Molecular docking and molecular dynamics studies revealed that key target proteins like serine/threonine-protein kinase (AKT1), peroxisome proliferator-activated receptor alpha (PPARA), and peroxisome proliferator-activated receptor gamma (PPARG), exhibited strong binding affinity and stable interactions with multiple phytocomponents present in DME. Moreover, the influence of DME on regulating the expression of essential gene targets, as identified in silico, has been verified through experimental validation using RT-Q-PCR. Freund's Complete Adjuvant (FCA)-induced chronic RA model animals further validated that DME could significantly ameliorate RA in experimental Wistar rat model. Quantitative RT-PCR results demonstrated that DME significantly (p<0.05) downregulated the mRNA expression of the core target gene AKT1, while enhancing the expressions of PPARG and Iκβ genes in the experimental animal groups compared to that in arthritic control group animals. Furthermore, our investigation revealed a noteworthy (p<0.05) downregulation of pro-inflammatory mediators such as COX-2, TNF-α, and IL-6, both at the gene and protein levels, suggesting noteworthy mitigation in the severity of inflammatory arthritis in the experimental animal groups.
Conclusion: In conclusion, the phytocomponents present in DME seem to act in a synergistic way to modulate key targets of inflammatory pathways associated with RA and could provide an immunomodulatory therapy for RA and associated chronic inflammations.
Research Innovation Lab on Ageing in a Digital Age : Summer School, 24th to 28th July 2023, Goethe University Frankfurt
Authors: Leontowitsch Miranda , Wanka Anna , Himmelsbach Ines , Wolf Friedrich , Oswald Frank
Published: July 2024

How can older adults participate equally in digitisation processes across Europe, and what inclusive research strategies are needed? This Zine summarizes findings from a “Research Innovation Lab on Ageing in a Digital Age”, funded by the VolkswagenStiftung, aiming to bring together 29 docs and postdocs anchored in 26 different disciplines coming from 11 countries, at all stages of their work, to address cutting edge questions relating to ageing in a digital age. Five groups worked together over five days in Frankfurt, Germany, in July 2023 in a creative and interactive hackathon, specific to developing non-technical solutions to social issues of this topic. Moreover, four distinguished experts presented keynote speeches and proposals from various conceptual, methodological and empirical perspectives.
VALORIZATION OF ONION AND TOMATO THROUGH SOLAR DRYING: CASE OF THE SHELL SOLAR DRYER
Authors:   Universite Joseph Ki-Zerbo 03 BP 7021 Ouagadougou 03, Burkina Faso., Bignan-Kagomna Bouwereou ,   Laboratoire denergies Thermiques Renouvelables (LETRE)., Winde Nongue Koumbem Daniel ,   Laboratoire denergies Thermiques Renouvelables (LETRE).,   Centre Universitaire de Kaya BP :232 Kaya Burkina Faso., Aziz Ouiminga Abdoul ,   Universite Joseph Ki-Zerbo 03 BP 7021 Ouagadougou 03, Burkina Faso.,   Laboratoire denergies Thermiques Renouvelables (LETRE)., Noufou Bagaya ,   Universite Joseph Ki-Zerbo 03 BP 7021 Ouagadougou 03, Burkina Faso.,   Laboratoire denergies Thermiques Renouvelables (LETRE)., Mibienpan Ki ,   Universite Joseph Ki-Zerbo 03 BP 7021 Ouagadougou 03, Burkina Faso.,   Laboratoire denergies Thermiques Renouvelables (LETRE)., Ouedraogo Issaka ,   Universite Joseph Ki-Zerbo 03 BP 7021 Ouagadougou 03, Burkina Faso.,   Laboratoire denergies Thermiques Renouvelables (LETRE).,   Institut de Recherche en Science Appliquees et Technologies (IRSAT).
Published: July 2024

One of the most widely grown vegetable crops in Burkina Faso is onion and tomato. Solar drying is crucial for the conservation of these products. One of the most accessible solar dryers is the shell solar dryer, which allows these products to be dried hygienically. We were able to obtain some results from the experiment carried out over three typical days with a solar dryer which shelled 1116 g of onion and 695 g of tomato cut and distributed on the three racks of the dryer. We observed a total water loss of 456 g for the onion and 257 g for the tomato from the first to the third day of the experiment. The shell solar dryer has an efficiency of 29.88% with an inlet temperature of 33Â°C, an outlet temperature of 76Â°C and an air mass flow rate of 0.004 kg/s. The average solar irradiation is 579 W/m 2.
MANAGEMENT OF MEDULLARY THYROID CARCINOMA
Authors:   Specialist General and Laparoscopic Surgeon, HMS-AL Garhoud Hospital - Dubai, UAE., Mohamed Ismail Amer Sobhy , Mohamed Mansour Hanaa ,   Specialist Obestetrics and Gynecology, Midcare Hospital -Sharjah, UAE.
Published: July 2024

Medullary thyroid carcinoma (MTC) compromises 3-10% of all thyroid cancers and arises from parafollicular C cells.This study reviews the current management of medullary thyroid carcinoma emphasizing the current practice in the preoperative diagnosis and evaluation of patients with MTC, and surgical treatment options for managing the thyroid and neck lymph nodes.
REDUCTION BLOOD LOSS IN TKA: TRANEXAMIC ACID ARTHROPLASTY UNIT: ARMED FORCES HOSPITAL SOUTHERN REGION, KHAMIS MUSHAIT, KSA
Authors:   Orthopedic Residents, Armed Forces Hospital Southern Region (AFHSR)., Altheeb S. , Maqbool A. ,   Medical Student Agha Khan University Karachi: Pakistan., Alshehri T. ,   Orthopedic Residents, Armed Forces Hospital Southern Region (AFHSR)., Qaysi A. ,   Arthroplasty Fellow at King Saud University Medical City., Maqbool M. ,   Arthroplasty Consultant, Armed Forces Hospital Southern Region (AFHSR).
Published: July 2024

Background:Total knee arthroplasty is the ideal surgical option for the management of severe pain in the arthritic knee.However, this surgery carries a high risk for blood loss due to the involvement of soft tissue and bone cuts in the knee region.Blood loss during Total Knee Replacement can lead toincreased morbidity, including longer stays in the hospital and delayed rehabilitation. Therefore, it is ideal to reduce the amount of bloodloss pre and post-operative. Tranexamic acidan anti-fibrinolytic agent has beenusedto achieve this goal with success. Aim:Our study is Cohort comparative study to compareefficacy of 1 Gram TXA with placebo group. Methods:This study was conducted at armed forces hospital southern region(AFHSR) on patients who performed primary total knee arthroplastyduring the period fromApril 2022 to December 2022 . The patients were simplerandomized into two groups those who received tranexamic acid and those who didnt. SPSS program version 23 was used to analyze the collected data a comparison was performed between the two groups. Results:The study included 50 patients who underwent total knee replacement Group one received tranexamic acid, and the Group Two didnt. The meanÂ±SD of the total patients was 69.8 Â±11.8 years, and regarding the two groups, there was no considerable difference between the two groups (P=0.2). There were significant differences between the two groups regarding gender (P=0.005) and dressing (P=0.002). There was no patient in the study who required a blood transfusion. Conclusion:TXA can be used for TKA patients to reduce blood loss postoperatively however, its impact on blood loss seems to be insignificant.
CLINICAL MANIFESTATIONS AND DIAGNOSTIC CHALLENGES OF KARTAGENER SYNDROME
Authors: Ouali A.El , Bounnite I. , Moussaoui S. , Labied M. , Mountassir C. , Lembarki G. , Sabiri M. , Lezar S.
Published: July 2024

Kartagener syndrome (KS) is an uncommon autosomal recessive genetic disorder characterized by the triad of bronchiectasis, chronic rhinosinusitis, and situs inversus. It is a specific phenotype within the spectrum of primary ciliary dyskinesia (PCD), a condition involving dysfunctional ciliary motility. Early diagnosis is crucial for effective management of the associated respiratory complications.
SHORT TERM FUNCTIONAL OUTCOME OF CLOSED REDUCTION AND FIXATION OF TIBIA SHAFT FRACTURES USING UNREAMED ENDERS NAIL IN ADULT POPULATION - A PROSPECTIVE STUDY
Authors: Mehra Sameer , Dang Balkrishna
Published: July 2024

Most of the tibial shaft fractures are the result of high energy trauma. There are various non surgical and surgical methods for managing tibial shaft fractures ranging from conservative casting, tubular external fixator, ring external fixator, open reduction and plating, reamed intramedullary interlocking nailing and unreamed intramedullary nailing. Aim of the study was to evaluate the functional outcomes of closed reduction with unreamed enders nailing as a definitive treatment option for closed tibial shaft fractures in adult population. In the study we included 150 adult patients who had sustained closed tibial fractures and underwent closed reduction and fixation with unreamed enders nailing within 12 hours of the injury. Eye of the nail, present at the distal end of the nails was locked. Total surgical time was averaged to 27.6 minutes. Evaluation was done by the time of clinical union, time of radiological union and VAS score. Ten patients had a delayed union. Two patients developed infection which was managed with oral antibiotics. In the conclusion, we found out that unreamed enders nailing procedure preserves the periosteum and its blood supply due to minimal exposure and improves the healing of fracture and decreases the incidence of infection. This method reduces the operative time, has a relatively less learning curve, reduces fluoroscopic exposure, reduces blood loss, reduces infection rate, doesnt expose the joint thus maintaining its congruity, reduces the cost of implant, reduces patient hospital stay, reduces the antibiotic usage and the implant removal at a later stage can be done as a day care procedure.
SOCIO-ECONOMIC FACTORS AND STUDENTS LEARNING OUTCOMES IN TWELVE YEARS BASIC EDUCATION IN RWANDA
Authors:   Mount Kenya University., Luc Ruberandinda , Faustin Mugiraneza ,   Mount Kigali University.
Published: July 2024

This studys objective was to examine the socio-economic factors affecting student learning outcomes in Twelve Years Basic education in Rwanda. The research question was: What are the socio-economic factors that affect students learning outcomes in Twelve Years Basic Education, in Rwanda? The researcher used descriptive survey research design. 182 respondents constituted the studys population. The researcher used census and purposive sampling techniques to find the sample of respondents. Questionnaires and documentation research techniques were used as tools for data gathering. Based on the responses from the respondents, the analysis of the findings using SPSS Version 21 showed a significant correlation with a p-value of 0.000, which is less than the usual significance level of 0.05 and indicates a very strong positive association between the students learning outcomes and the socio-economic factors of family income, parental level of education, school resources, and food security. The Karl Pearson correlation coefficient (r), of 0.870, provided additional evidence of this strong positive relationship.
THE PREVALENCE OF MOTION SICKNESS IN YOUNG ADULTS OF MYSORE, KARNATAKA
Authors: Kishor Dwivedi Amitabh , Binoy Abiya , KarippayilIype Donna , B. Shashirekha , Kulkarni Praveen
Published: July 2024

Background: Motion sickness is a common condition characterized by symptoms such as nausea, dizziness, and vomiting, triggered by movements during travel or other activities. Despite its impact across all ages, there is lack of studies in the prevalence among 18â€“ 28 years individuals.Understanding its effects on the quality of life and productivity is crucial for developing effective interventions. Objectives: To investigate the prevalence of motion sickness among age 18 â€“28 years. Methods:A convenient sampling approach was employed, involving 562 participants (463 females, 99 males), aged 18 - 28 years from various departments of JSSAHER. Participants completed the Motion Sickness Susceptibility Questionnaire (MSSQ) short form to assess their susceptibility. Additionally, the Motion Sickness Assessment Questionnaire (MSAQ) was administered at the end of travel to evaluate the severity of symptoms experienced by them. Results:In this study of 562 participants (463 females, 99 males), 71.4% mild, 27.8% moderate, and 0.9% severe. The mean age was 19.89 years. There was no significant association between gender and motion sickness severity (p = 0.264), but age showed a significant correlation with motion sickness severity (p = 0.014). Linear regression indicated a weak positive relationship between age and motion sickness score (Beta = 0.196, p < 0.05), explaining 3.9% of the score variability. Conclusion: The study highlights the importance of motion sickness that impacts young adults quality of life and occupational performance. Currently, there is no permanent solution, highlighting further research and intervention strategies.
REDESIGNING THE LIFE CYCLE OF POLYURETHANE FOR SUSTAINABLE GROWTH: EXPLORING ALTERNATIVE CHEMISTRIES AND MITIGATING ENVIRONMENTAL HAZARDS
Authors: Batra Bhavik
Published: July 2024

Polyurethane is a widely utilised polymer in many industrial applications, however because of its flammability and nature as a feedstock, it is seen as a difficult material to support. Redesigning the life cycle to guarantee sustainable growth by lowering environmental impact and reliance on non-replaceable resources is essential to effective management strategies. In order to address sustainability concerns, the next article looks at alternate chemistries and manufacturing techniques, emphasising the necessity of innovation and cooperation both within and between industry.
THE PILOMATRICOMA: A CASE REPORT OF PALPEBRAL LOCALIZATION
Authors:   ENT Department of Specialized Hospital of Rabat, CHU-IBN Sina, Faculty of Medecine., Vasthi Ngouya Koumba Hernandez ,   Mohammed V University of Rabat, Morocco., Hafi Z. El ,   ENT Department of Specialized Hospital of Rabat, CHU-IBN Sina, Faculty of Medecine., Bencheikh R. ,   ENT Department of Specialized Hospital of Rabat, CHU-IBN Sina, Faculty of Medecine., Benbouzid A. ,   ENT Department of Specialized Hospital of Rabat, CHU-IBN Sina, Faculty of Medecine., Errami N. ,   ENT Department of Specialized Hospital of Rabat, CHU-IBN Sina, Faculty of Medecine., Essakalli L. ,   ENT Department of Specialized Hospital of Rabat, CHU-IBN Sina, Faculty of Medecine.
Published: July 2024

Pilomatricoma, formerly called calcified epithelioma of Malherbe, is a rare and benign skin tumor occurring during the first two decades of life, generally located in the upper part of the body (neck and head). In its typical form, it manifests clinically as a small, solitary, asymptomatic, sometimes painful subcutaneous nodule. The usual size is less than 3 cm. The diagnosis is made clinically and requires histological confirmation. The prognosis is generally good. Carcinomatous transformation remains controversial. Healing without recurrence is the rule after surgical excision. Ocular or palpebral localization is exceptional. We report the case of Mrs. G.E, 26 years old, without any notable pathological history, who consulted for a mass on the right eyelid that had been developing for 1 year. Objective clinical examination: a polylobed mass, well defined, 3 cm long axis, hard, painless and mobile in relation to the deep plane. The surrounding skin is normal in appearance. In addition, motor skills and ocular mobility remain preserved. A total surgical excision is performed. Histological study of the biopsy specimen reveals the presence of basaloid cells covering layers of mummified cells with eosinophilic cytoplasm, suggestive of a Malherbe Pilomatricoma. No recurrence was detected after a 12-month follow-up.
FAMILY CONFLICTS AND STUDENTS DROP OUT IN PUBLIC PRIMARY SCHOOLS IN RWANDA, A CASE OF BUGESERA DISTRICT RWANDA
Authors:   MED Student, Mount Kenya University., Jean Claude Harerimana , Faustin (PhD) Mugiraneza ,   Senior Lecturer, Mount Kenya University.
Published: July 2024

The effect of family conflicts on childrens education is significant and can affect various aspects of their educational outcomes.The Objective of the study was to assess the effect of family conflicts on student dropout rates in public primary schools in Bugesera District, Rwanda.. This research was supported with system theory and Maslows hierarchy of needs Theory. The researcher used descriptive research design for data collections. The participants were students, parents, teachers and Head teachers. All respondents was 960 including 30 headteachers 120 teachers,360 parents and 450 Students from 30 schools sampled schools from 15 sectors of Bugesera District, Rwanda. The Yamane formula was used to calculate the sample size of 282 respondents. The participants was chosen by using different methods where researcher was random sampling and purposive sampling. Researcher was questionnaire and interview guide as data collection instruments where Questionnaire was designed to parents and interview guide was designed for schools heads, teachers and students. Researcher used IBM.SPSS 22.0 in analysis procedure.Table 4.16 in the study revealed a strong relationship between family conflict and students drop out rate in public primary schools. This relationship was substantiated by a Pearson correlation coefficient (r) of 0.948, which was associated with a statistically significant p-value of 0.000 for a two-tailed test. This suggests a highly positive and statistically significant association between family conflicts and students drop out . The findings also found in table 4.17 that all variables are coherent and students drop out is caused by family conflict within the family as it is shown by the regression analysis model with Square of 0.898 means that the all kinds of family conflict affect significantly students schooling including students drop out. Government should enact policies that prioritize family well-being and address the underlying socioeconomic determinants of family conflicts, such as poverty, unemployment, and inadequate social services. The Ministry of Education should integrate family conflict resolution programs into the national curriculum, equipping students with conflict resolution skills and fostering familial cohesion. Headteachers should foster a supportive school environment that prioritizes the well-being of students and families. Teachers should Cultivate a safe and supportive classroom environment where students feel valued, respected, and empowered to express themselves.
ANALYSIS OF EFFICACY OF COLLAGEN DRESSING VERSUS CONVENTIONAL DRESSING IN CHRONIC WOUND
Authors: Devdikar Shrutik , Reza Ali , Parsania Tisha , Jha Nilind , Vardey Mohit , Guntupalli Akhil
Published: July 2024

A breach in continuity of the covering epithelium either of skin or of mucus membrane is defined as ulcer. Chronic or non-healing ulcers are defined as ulcers that are unresponsive to initial treatment or that persist for more than 3 weeks after appropriate care and management. Chronic nonhealing ulcers not only have a medical challenge but have social, economical and occupational effects on the patient. Ulcers have been treated conventionally by cleansing, debridement and removal of necrotic and infected tissue which was followed by dressing with topical antiseptic like Povidone iodine, antibiotic ointment, silver ointment, etc. Collagen is a group of naturally occurring proteins found in all phases of wound healing. Collagen is a key component of extracellular matrix which plays critical roles in the regulation of the phases of wound healing in its native fibrillar conformation or as a soluble component.Collagen helps wound healing through deposition and organisation of freshly formed fibres and granulation tissue in the wound bed which creates a good environment for wound healing.Collagen sheets when applied to a wound promote angiogenesis and also enhance bodyÂ’s repair mechanisms Our Aim is To compare the efficacy of the conventional dressing and collagen dressing in chronic wound in terms of Average time required for appearance of Granulation tissue, Requirement of Skin Grafting and mean Hospital Stay. Based on the type of dressing used, patients were divided into 2 groups, Group A(49) patients were dressed with conventional dressing, Group B patients (51) were dressed with collagen making a total of 100 patients. Appearance of healthy granulation tissue was observed to be significantly earlier among patients of collagen dressing group as compared to other group .The observed difference between number of days of hospital stay of patients with collagen dressing was statistically significant as compared to other group Thus Collagen based dressing were observed to be superior from conventional dressings in terms of aspects of healing viz. appearance of healthy granulation tissue.
SYNTHESIS, SPECTRAL STUDIES AND EVALUATION OF DNA BINDING, PHOTOCLEAVAGE, ANTICANCER ACTIVITY OF RU(II) POLYPYRIDYL COMPLEXES OF 2-(3,4,5-TRIMETHOXY-PHENYL)-H-IMIDAZOLE[4,5-F][1,10]PHENANTHROLINE
Authors:   Department of Chemistry, University College of Science, Saifabad, Osmania University, Hyderabad -500004, Telangana State, India., Gudikandula Sravani , Nambigari Navaneetha ,   Department of Chemistry, University College of Science, Saifabad, Osmania University, Hyderabad -500004, Telangana State, India.,   Department of Chemistry, University College of Science, Osmania University, Tarnaka, Hyderabad - 500007, Telangana State, India.
Published: July 2024

The two novel Ru(II) polypyridyl complexes of the type [Ru(NN)2L](ClO4)2.2H2O,where NN is dmp=4,4-dimethyl-1,10 ortho phenanthroline and dmb=4,4-dimethyl 2,2-bipyridine and L is Intercalator ligand, TMIP=2-(3,4,5-Trimethoxy-phenyl)-H-imidazole[4,5-f][1,10]phenanthroline were synthesized and characterized by different spectroscopic techniques. The binding ability of Ru (II) complexes with CT-DNA was investigated by Biophysical studies â€“ UV-Visible absorption studies, Fluorescence studies (Emission & Quenching) and Viscosity studies. The binding constants of these complexes from absorption studies are 1.2x105 M-1and 8x104M-1respectively.These values are less as compared to the existing TMIP complex [Ru(phen)2TMPIP]+2, indicative of the effect of substitution over the ancillary ligand which reduce the binding capacity of metal complex to CT-DNA. The results from the viscosity studies suggest an intercalative binding mechanism. The DNA cleavage studies show that the Ru (II) complexes successfully cleaved the pBR322 DNA. Both the complexes exhibit not notable anti cancer acivity.
BRITISH ADMINISTRATION AND ITS IMPLICATIONS ON MIZORAM FOREST
Authors:   Associate Professor, Department of History, Govt. J. Thankima College, Aizawl, Mizoram., Vanlalruati C. , a Zarzoliana ,   Associate Professor, Department of Geography, Govt. Hrangbana College, Aizawl, Mizoram., V.L. Thlanga Samuel ,   Associate Professor, Department of History, Govt. Aizawl West College, Aizawl, Mizoram.
Published: July 2024

The Colonial history of Mizoram (Lushai Hills district) witnessed a very little state intervention in matters of religion and customs. The advent of Christianity and education was phenomenal in changing the animistic world view and attitude of the people towards natural features and use of resources. The Lushai Hills district being a single political entity with fixed boundaries governed by Inner line Regulation, villages were concentrated in a given domain and the people were forced to rely on the shrinking resources domains to meet basic needs. Though Forest Department was created to enforce the State dominion over forest resources, the degrees of imperial control are different in the hill areas. In Lushai Hills district, concern to maintain public order outweighed the economic interests. The hill forests had less commercial potential in terms of species and their number and poor accessibility tended to restrict timber exploitation to areas on the route of navigable rivers. Small and localized reserves such as, riverine, roadside, and town reserves were created by executive order. Outside the reserves, people were entitled to remove forest produce for consumption. While the people utilized forest and fields as the basic resources for survival, the government utilized it for wealth.
PERFORMANCE OF RAPID POLYMYXIN NP TEST AMONG TWO SPECIES OF FAMILY ENTEROBACTERIACEAE
Authors:   Department of Obstetrics and Gynecology, Postgraduate Institute of Medical Education & Research, Chandigarh., Kaur Parneet , Rashmi Mudliar S. ,   Department of Microbiology, All India Institute of Medical Sciences, Nagpur., Khadanga Sagar ,   Department of General Medicine, All India Institute of Medical Sciences, Bhopal., Saigal Saurabh ,   Department of Anaesthesiology, All India Institute of Medical Sciences, Bhopal., Tadepalli Karuna ,   Department of Microbiology, All India Institute of Medical Sciences, Bhopal.
Published: July 2024

Objectives: Performing polymyxin susceptibility testing is a challenge in resource limited settings with broth microdilution as a standard method. Nordmann and Poirel introduced Rapid Polymyxin NP Test, qualitative calorimetric test for interpreting the susceptibility or resistance to colistin for Enterobacteriaceae. Due to limited data on the diagnostic accuracy of the test in central region of India, the current study was conducted to assess the diagnostic accuracy with ease of performance of Rapid polymyin NP test in comparison to the reference method, broth microdilution for Carbapenam resistant Escherichia coli and Klebsiella pneumoniae, the two prevalent species isolated across samples. Methods: Single center tertiary care hospital based cross sectional study for a period of eight months. The Rapid polymyxin NP test and broth microdilution test was performed for 13 isolates of carbapenam resistant E.coli and 10 isolates of Klebsiella pneumoniae sub species pneumoniae, including only one isolate per patient. Results: Rapid Polymyxin NP test showed 86.95% sensitivity and 100% specificity when compared to BMD test. Time to positivity by rapid polymyxin NP ST was 3 to 4 hrs when compared to BMD ST which was as almost 10-12hrs. Conclusions: The specificity of 100% for the Polymyxin NP test indicates that it may be utilized as a confirmatory test. With the sensitivity as 86.95% Polymyxin NP test can be used as a very good screening test. The NPV was 40% hence whenever the test result is resistant by Polymyxin NP test one can only be 40% sure that it is a true resistant.
PROJECT MANAGEMENT TRIPLE CONSTRAINTS ON PERFORMANCE OF NON-GOVERNMENTAL PROJECTS IN RWANDA A CASE OFNGOS IN BUGESRA DISTRICT
Authors:   Department, Business Administration, Mount Kenya University, Rwanda., Urezweneza Edyna , Gitahi Njenga ,   Department, Business Administration, Mount Kigali University.
Published: July 2024

Background: This study aimed to examine the impact of project triple restrictions on the performance of Rwandan non-governmental initiatives. It focused on time management, cost management, and scope management on the effectiveness of these projects. The research was guided by three theories: theory of constraints, Goal Setting Theory, and Complexity Theory. The study involved 12 Local NGOs in Bugesera district, with a target population of 120 individuals. Primary data was gathered through questionnaires, while secondary data was gathered from various sources. The reliability level was determined using Cronbachs Alpha. Methods and Materials: Data analysis was conducted using SPSS (v25), and key themes related to scope management practices, project performance indicators, and contextual factors influencing NGO projects in Rwanda were identified. Quantitative data was analyzed using descriptive and inferential statistical techniques, such as correlation analysis or regression modeling, to examine relationships between variables and test hypotheses. Results:The findings reveal that in the context of non-governmental projects in Bugesera District, Rwanda, effective scope management significantly influences project performance, with a standardized coefficient of .870 (p < .001), indicating a strong positive relationship. Time management also demonstrates a significant negative impact on performance (Î² = -.195, p = .008), highlighting the importance of efficient scheduling and timely completion of tasks. However, cost management does not exhibit a significant influence on project performance (Î² = .020, p = .771). The study indicates that effective scope management plays a pivotal role in enhancing the performance of non-governmental projects in Bugesera District, Rwanda, demonstrating a strong positive relationship with project outcomes. Conversely, while time management significantly affects project performance negatively, the influence of cost management appears to be non-significant in this context, suggesting that prioritizing scope alignment and efficient scheduling is crucial for project success. Conclusion: Based on the findings, it is recommended that NGOs operating in Bugesera District prioritize effective scope management to optimize project performance, ensuring clear alignment with objectives and deliverables. Additionally, attention should be given to improving time management practices to minimize delays and enhance project efficiency, while maintaining a vigilant approach to cost management to prevent budget overruns and resource misallocation.
INTEGRATING THEORY AND PRACTICE IN CREATIVE DISCIPLINES: A LONGITUDINAL STUDY OF (RE-)ADAPTIVE LEARNING MODELS AND COMPETENCE DEVELOPMENT WITHIN A COMMUNITY OF PRACTICE
Authors:   Professor and Dean of Studies, Department of Media Business and Media Management, Digital Games Business, and UX-Design, Diploma Hochschule, University of Applied Sciences, Bad Sooden-Allendorf (Germany)., Vindigni Giovanni ,   Professor and Doctoral Advisor, Department of Economics, Global Humanistic University the Valley (AI).,   Doctoral Advisor/Doctoral Supervisor, Middlesex University (UK).
Published: July 2024

This study scrutinises the prevailing paradigm of disseminating knowledge through conventional instructional methodologies such as lecturing, which often fail to cultivate the comprehensive skill sets requisite in contemporary professional environments. It addresses the disconnect between traditional teaching practices and learner expectations by proposing innovative instructional design frameworks. This research contributes to filling extant gaps in the literature regarding the dynamics of competence development across university curricula, where previous studies, overly reliant on self-assessments, have not adequately captured these dynamics. Employing a longitudinal, mixed methods approach and multiple forms of triangulation, this study comprehensively examines the processes of constructing, modifying, and enhancing professional knowledge, skills, and attitudes. It embraces technological integration, individualization, the transfer of theory into practice, re-adaptive teaching, and adaptive course methodologies. The significance of the findings is profound, offering critical insights into enhancing professional competence across diverse academic disciplines.
REDUCING RESPIRATORY VARIATIONS IN INTERNAL JUGULAR VEIN CROSS-SECTIONAL AREA USING PEEP AND TRENDELENBURG POSITION
Authors:   Post Graduate Student, Department of Anaesthesia, MRMC, Kalaburagi., D.S Anush , S. Kamareddy Pratima ,   Professor and Head of Department, Department of Anaesthesia, MRMC, Kalaburagi., Gadgi Siddaramesh ,   Assistant Professor, Department of Anaesthesia, MRMC, Kalaburagi., N. Adilakshmi ,   Post Graduate Student, Department of Anaesthesia, MRMC, Kalaburagi., Wali Shilpa ,   Post Graduate Student, Department of Anaesthesia, MRMC, Kalaburagi.
Published: July 2024

Introduction: The respiratory cycle influences the size of the right internal jugular vein (RIJV). We evaluated the changes in RIJV size during the respiratory cycle in patients on positive pressure ventilation. Additionally, we investigated the impact of positive end-expiratory pressure (PEEP) and the Trendelenburg position on these respiratory fluctuations. Methods: The study involved 24 patients who underwent general endotracheal anesthesia. Images of the right internal jugular vein (RIJV) were captured in the supine position (baseline, S0) and during three randomized maneuvers: applying a positive end-expiratory pressure (PEEP) of 10 cmH2O (S10), positioning the patient in a 10Â° Trendelenburg tilt (T0), and combining the Trendelenburg tilt with PEEP (T10). The aim was to measure the cross-sectional area (CSA), anteroposterior diameter, and transverse diameter of the RIJV at both its smallest and largest observed sizes during each maneuver. Results: The study found that all maneuvers significantly reduced the fluctuation in the size of the right internal jugular vein (RIJV) (p = 0.0004). Specifically, compared to the supine position (S0), the maneuvers resulted in the following decreases in the cross-sectional area (CSA) from the smallest to the largest observed sizes: Â• S0: Decrease by 28.3% Â• S10: Decrease by 8.5% Â• T0: Decrease by 8.0% T10: Decrease by 4.4% Additionally, compared to S0, the combination of a 10Â° Trendelenburg tilt position with a positive end-expiratory pressure (PEEP) of 10 cmH2O significantly increased the CSA: Â• In the largest observed areas by 83.8% Â• In the smallest observed areas by 169.4% These findings suggest that the Trendelenburg tilt combined with PEEP was particularly effective in increasing the CSA of the RIJV, both at its largest and smallest observed sizes, compared to other maneuvers and the baseline supine position. Conclusions: A 10Â° Trendelenburg tilt position combined with a PEEP of 10 cmH2O not only increases the size of the RIJV but also reduces fluctuation by the respiratory cycle.
EFFICACY OF VIRTUAL REALITY EXPOSURE THERAPY FOR THE TREATMENT OF POST TRAUMATIC STRESS DISORDER IN ADULTS
Authors:   Student of Gautam Buddha University, Uttar Pradesh, India., Tyagi Shristi
Published: July 2024

The emergence of new technologies like enhanced immersion and realism providing realistic stimulations, biometric sensor integration having physiological monitoring like heart rate monitors and conductance sensors which allow the observation and monitoring of patients behaviour and their responses and combining the reality with VR technology have altogether made the Virtual Reality Exposure Therapy more effective for the treatment of phobias and Post Traumatic Stress Disorder [1]. The efficacy of VRET in treatment of PTSDcan be observed through various studies conducted on war veterans, general population and people suffering from stressful traumatic memories of the past.Astudy was conducted to assess the treatment ofPTSD through VRET in the survivors of 9/11 attacks revealed significant reductions in symptoms with large effect size (d=1.50).
Retos de la enseñanza, por parte de una docente rural en Caldono-Cauca, en medio del Covid 19
Authors: Soto Vargas Karol Dayana , Clavijo Montenegro Dayanna , Rebolledo Medina Juan Felipe , Urrea Cuéllar Angela María
Published: July 2024

La presente investigación consiste en identificar los retos de la enseñanza de una docente rural de Caldono-Cauca (Colombia), en medio del Covid 19. Para ello, se entrevistó a una docente de 29 años, residente de la zona rural de Caldono (Cauca, Colombia), miembro del resguardo indígena Nasa, quien ejerce como docente de Licenciatura en Educación Popular hace 9 años en la escuela “El Nazareno”. Por medio, del discurso de la docente se evidencia que ha desarrollado habilidades, por medio de las cuales los niños aprendieron a valorar su proceso, permitiendo la personalización del proceso, el cual generó mayor atención, y al mismo tiempo retrasó el desarrollo temático, provocando desinterés y pereza intelectual. Es por ello, que la docente expresa que el trabajo desde la pedagogía contextual con enfoque social, permite el refuerzo de habilidades en los estudiantes, utilizando los recursos que tienen disponibles para el desarrollo de las clases. Como conclusión de este proceso se resalta la necesidad de implementar políticas públicas que atiendan las particularidades de la educación rural, garantizando el acceso a recursos tecnológicos y materiales adecuados, así como el fortalecimiento de la formación docente en contextos específicos.
De las obras de arte aplicado a los diseños industriales: una hoja de ruta hacia el reconocimiento de los derechos morales del diseñador industrial
Authors: Acevedo Caicedo Francisco José , Vargas Chaves Iván
Published: July 2024

El artículo examina la equiparación de los derechos morales de autor para diseñadores industriales y creadores de obras de arte aplicado bajo el régimen de propiedad intelectual de la Comunidad Andina. Se emplea un enfoque comparativo entre ambas categorías de creadores, utilizando una metodología de análisis documental interpretativo. Se argumenta que tanto la doctrina como la jurisprudencia reconocen una doble protección para obras de arte aplicado y diseños industriales. Se destaca la importancia de reconocer los derechos morales de paternidad e integridad a favor de los diseñadores industriales, similar a lo establecido para las obras de arte aplicado. Se proponen directrices para resolver la laguna normativa existente, con el fin de proteger el interés jurídico de los creadores en sus obras y diseños.
Análisis de políticas públicas y controversias, una agenda de investigación
Authors: Muñoz Gaviria Gustavo Adolfo , Muñoz Gaviria Edwin Alberto , Arango Salazar Carolina
Published: July 2024

En este texto se proponen fundamentos teóricos y metodológicos para el desarrollo de un marco de análisis de políticas públicas, desde la comprensión e la acción de los actores de la política y de los mecanismos que posibilitan o restringen su capacidad crítica y de concreción de sus intereses. Para ello, se propone a la Administración Pública configurar una línea de investigación que problematice la influencia de la economía política del Estado en cada una de las etapas de formulación e implementación de las políticas públicas, por medio del método comprensivo que ha desarrollado la escuela francesa de la sociología pragmática.
Paz Territorial Urbana: Retos e implicaciones en el distrito de Medellín, Colombia
Authors: Insuasty Rodríguez Alfonso , Zuluaga Cometa Héctor Alejandro
Published: July 2024

Es relevante entonces, construir una mirada común de ciudad, de esas diversas ciudades que en realidad componen el distrito de Medellín, la ciudad de las laderas, la rural campesina, la ciudad de los tenedores, poseedores y propietarios, la de la gran familia de la economía informal, la de los moradores e incluso la de los habitantes de calle. Esta mirada compartida debe derivar en una agenda colectiva que oriente los Planes de Desarrollo en sus diferentes niveles territoriales y aún más, los Planes de Ordenamiento Territorial (POT) promoviendo una red-ciudad más inclusiva y equitativa. Este proceso concreto, real, participativo, es a lo que deberíamos considerar, de manera cierta, el caminar hacia una Paz Territorial Urbana.
Entre a paz perpétua e as guerras eternas
Authors: Soares Sônia
Published: July 2024

Neste ensaio, busco responder à questão colocada, a partir do texto kantiano A Paz Perpétua, no contexto dos seus escritos políticos, e da sua filosofia moral, aplicada à função do cientista, considerando que um dos maiores desafios da humanidade no ano de 2024 é a manutenção da paz. Inicio minha resposta, expondo a concepção de Kant sobre a guerra como instrumento da natureza necessário à realização do fim da humanidade; na sequência, apresento alguns instrumentos do direito internacional visando à manutenção da paz; por fim, incorporo o direito universal à ciência como elemento indispensável à proposta de Kant na solução do problema analisado, à luz de suas considerações sobre a relação entre moralidade e conhecimento científico. Concluo que é preciso resgatar o papel da ética e da responsabilidade científica, investindo na formação científica e virtuosa de jovens.
Guerra e paz em Kant e Hegel
Authors: Araújo da Silva Márcia Zebina
Published: July 2024

O artigo analisa o conflito em Gaza a partir das filosofias da história de Kant e de Hegel.
INSIGHTS DE UM ESTUDO DE MAPEAMENTO SISTEMÁTICO DA TECNOLOGIA 5G NO CONTEXTO DA AGRICULTURA SUSTENTÁVEL
Authors: Nascimento Sidney Cassemiro do , Holanda Francisco Sandro Rodrigues
Published: July 2024

A tecnologia 5G está se tornando essencial para impulsionar a agricultura sustentável nas próximas décadas. O objetivo deste trabalho foi caracterizar as pesquisas relacionadas à tecnologia 5G no contexto da agricultura sustentável, contribuindo assim para o avanço do conhecimento científico e o estímulo de debates sobre as mudanças tecnológicas na agricultura com o apoio do 5G. Realizou-se um mapeamento sistemático das publicações científicas sobre o uso da tecnologia 5G na agricultura sustentável, abrangendo discussões desde o início da temática até o presente momento. Os resultados revelaram que os termos mais frequentes na pesquisa indicam um foco em tecnologias inteligentes e precisas na agricultura. Foi identificada também uma abordagem interdisciplinar na aplicação do 5G na agricultura sustentável, com interconexões entre diferentes campos de conhecimento. Os resultados destacam o crescente interesse e a relevância do 5G na agricultura sustentável, oferecendo insights para futuras investigações e desenvolvimentos tecnológicos.
Associations of Multimorbidity with Cerebrospinal Fluid Biomarkers for Neurodegenerative Disorders in Early Parkinson's Disease: A Crosssectional and Longitudinal Study
Authors: Zhang Ming-Zhan , Sun Yan , Chen Yan-Ming , Guo Fan , Gao Pei-Yang , Tan Lan , Tan Meng-Shan
Published: July 2024

Object:

The study aims to determine whether multimorbidity status is associated with
cerebrospinal fluid (CSF) biomarkers for neurodegenerative disorders.

Methods:

A total of 827 patients were enrolled from the Parkinson’s Progression Markers Initiative
(PPMI) database, including 638 patients with early-stage Parkinson’s disease (PD) and 189
healthy controls (HCs). Multimorbidity status was evaluated based on the count of long-term conditions
(LTCs) and the multimorbidity pattern. Using linear regression models, cross-sectional and
longitudinal analyses were conducted to assess the associations of multimorbidity status with CSF
biomarkers for neurodegenerative disorders, including α-synuclein (αSyn), amyloid-β42 (Aβ42), total
tau (t-tau), phosphorylated tau (p-tau), glial fibrillary acidic protein (GFAP), and neurofilament
light chain protein (NfL).

Results:

At baseline, the CSF t-tau (p = 0.010), p-tau (p = 0.034), and NfL (p = 0.049) levels
showed significant differences across the three categories of LTC counts. In the longitudinal analysis,
the presence of LTCs was associated with lower Aβ42 (β < -0.001, p = 0.020), and higher t-tau
(β = 0.007, p = 0.026), GFAP (β = 0.013, p = 0.022) and NfL (β = 0.020, p = 0.012); Participants
with tumor/musculoskeletal/mental disorders showed higher CSF levels of t-tau (β = 0.016, p =
0.011) and p-tau (β = 0.032, p = 0.044) than those without multimorbidity.

Conclusion:

Multimorbidity, especially severe multimorbidity and the pattern of mental/musculoskeletal/
tumor disorders, was associated with CSF biomarkers for neurodegenerative disorders
in early-stage PD patients, suggesting that multimorbidity might play a crucial role in aggravating
neuronal damage in neurodegenerative diseases.
Volatilome is Inflammasome- and Lipidome-dependent in Ischemic Heart
Disease
Authors: Marzoog Basheer Abdullah
Published: July 2024

:

Ischemic heart disease (IHD) is a pathology of global interest because it is widespread
and has high morbidity and mortality. IHD pathophysiology involves local and systemic changes,
including lipidomic, proteomic, and inflammasome changes in serum plasma. The modulation
in these metabolites is viable in the pre-IHD, during the IHD period, and after management
of IHD in all forms, including lifestyle changes and pharmacological and surgical interventions.
Therefore, these biochemical markers (metabolite changes; lipidome, inflammasome, proteome)
can be used for early prevention, treatment strategy, assessment of the patient's response to the
treatment, diagnosis, and determination of prognosis. Lipidomic changes are associated with the
severity of inflammation and disorder in the lipidome component, and correlation is related to
disturbance of inflammasome components. Main inflammasome biomarkers that are associated
with coronary artery disease progression include IL‐1β, Nucleotide-binding oligomerization domain-
like receptor family pyrin domain containing 3 (NLRP3), and caspase‐1. Meanwhile, the
main lipidome biomarkers related to coronary artery disease development involve plasmalogen
lipids, lysophosphatidylethanolamine (LPE), and phosphatidylethanolamine (PE). The hypothesis
of this paper is that the changes in the volatile organic compounds associated with inflammasome
and lipidome changes in patients with coronary artery disease are various and depend
on the severity and risk factor for death from cardiovascular disease in the time span of 10 years.
In this paper, we explore the potential origin and pathway in which the lipidome and or inflammasome
molecules could be excreted in the exhaled air in the form of volatile organic compounds
(VOCs).