bluuebunny/crossref_metadata_2025 huggingface dataset:
Hubungan Tingkat Pengetahuan tentang Bahaya Barodontalgia dengan Status Karies Gigi pada Instruktur Penyelam di Kota Manado
Authors: Mintjelungan Christy N. , Mariati Ni Wayan , Galongi Junistika P.
Published: May 2024

Abstract: Knowledge can be the basis of attitudes towards something and ultimately underlies a person's behavior. Barodontalgia is oral pain that occurs due to changes in barometric pressure and its most common cause is caries. This study aimed to evaluate whether there was a relationship between level of knowledge about the dangers of barodontalgia and dental caries status among diving instructors in Manado. This was a descriptive and analytical study with a cross-sectional design. Samples were obtained by using the total sampling technique to all diving instructors who came to the Youth Center pier from January to February 2023. The results obtained 36 diving instructors as subjects. The level of knowledge about barodontalgia of subjects was considered as sufficient and the population DMF-T index was 3.22. The Spearman correlation test resulted in p=0.148 and r=0,246. In conclusion, there was a non-significant relationship with a weak correlation between the level of knowledge about the dangers of barodontalgia and dental carries status among diving instructors in Manado.
Keywords: barodontalgia; knowledge level; DMF-T; diving instructors
 
Abstrak: Pengetahuan dapat menjadi dasar untuk bersikap terhadap sesuatu dan akhirnya mendasari perilaku seseorang. Barodontalgia adalah nyeri oral yang timbul karena adanya perubahan tekanan barometrik dan paling banyak ditemukan pada penderita karies gigi. Penelitian ini bertujuan untuk mengetahui ada tidaknya hubungan antara tingkat pengetahuan tentang bahaya barodontalgia dengan status karies gigi pada instruktur penyelam di Kota Manado. Jenis penelitian ialah deskriptif analitik dengan desain potong lintang. Pengambilan sampel menggunakan teknik total sampling terhadap seluruh instruktur penyelam yang datang di Dermaga Youth Center pada Januari hingga Februari 2023. Hasil penelitian mendapatkan 36 instruktur penyelam sebagai subjek. Tingkat pengetahuan tentang barodontalgia pada instruktur penyelam tergolong cukup dan indeks DMF-T populasi bernilai 3,22. Hasil uji korelasi Spearman mendapatkan nilai p=0,148 dengan nilai r=0,246. Simpulan penelitian ini ialah terdapat hubungan tidak bermakna dan korelasi lemah antara tingkat pengetahuan tentang bahaya barodontalgia dengan status karies gigi pada instruktur penyelam di Kota Manado.
Kata kunci: barodontalgia; tingkat pengetahuan; DMF-T; instruktur penyelam
Implementation of An Android-Based Mobile Application for Real-Time Student Learning Reports at SMP IDN Jonggol, West Java
Authors: Mulyana Dadang Iskandar , Albahy Abdurrahman A. , Khalid Muhammad , Siregar Muhammad Hafiz , Sadid Muhammad Umar Arib
Published: May 2024

This research implements an Android-based mobile application for real-time student learning reports at IDN Jonggol Middle School, West Java, which can provide information about real-time student learning reports at IDN Jonggol Middle School using an Android-based mobile application. This research was conducted because many parents of IDN Middle School students wanted to see their children's development directly. This research aims to implement an Android-based application to help parents of students at IDN Middle School monitor their children's learning progress in real time by applying technology that is currently developing and making it easier for parents to access information about their children's development anywhere and anytime. This qualitative research method aims to create a system and display the information presented in the application being created. To obtain data relating to student learning progress, we could access the data in spreadsheet form. With the Android application in this research, parents can access information about their child's learning progress directly anytime and anywhere.
Internet of Medical Things and the Evolution of Healthcare 4.0: Exploring Recent Trends
Authors: Mukhopadhyay Manishka , Banerjee Subhrajyoti , Das Mukhopadhyay Chitrangada
Published: May 2024

Enhanced patient care and remote health monitoring have always been important issues. Internet of Medical Things (IoMT) is a subsection of Healthcare 4.0 that uses recent technologies like mobile computing, medical sensors, and cloud computing to track patients' medical information in real-time. These data are stored in a cloud computing framework that may be accessed and analyzed by healthcare experts. IoMT and Healthcare 4.0 have immense potential for revolutionizing patient care and diagnostics, despite facing numerous complex challenges. This paper thoroughly analyzes technical, structural, and regulatory obstacles encountered by the healthcare sector. Challenges in IoMT implementation include cost considerations, network stress, interoperability issues, ethical limitations, policy intricacies, security concerns, and vulnerabilities jeopardizing patient privacy. However, amidst these challenges, the study highlights the prospective long-term benefits, including diminished medical costs and enhanced patient care. In this study, we have portrayed a comprehensive exploration of the field of IoMT and different related technologies from more than 100 papers to represent the transformation and growth in this decade. We have illustrated some of the significant findings of applications and innovations in the domain of IoMT. This paper delves into IoMT's application in dementia detection and care, improved data management, fortified cybersecurity measures, and modernizing existing healthcare systems. The study also offers valuable insights into potential mitigation strategies, offered by ongoing research and innovation to address emerging trends and challenges, propelling the trajectory of Healthcare 4.0 towards an optimized and transformative future for patient well-being. Hence future research needs to integrate more prudent technologies addressing challenges including security, privacy, interoperability, and implementation costs.
BUSINESS DIGITAL TRANSFORMATION TRENDS IN THE ECOSYSTEM OF GEORGIA
Authors: Makasarashvili Tamar , Giguashvili Giuli , Khorguashvili Tea , Orjonikidze Nino
Published: May 2024

A necessary condition for the success of the Georgian economy is solving problems in creative and innovative ways, building an economy based on knowledge and innovation, digital transformation in the Georgian ecosystem along with the latest technologies, and national innovative potential utilization, thereby accelerating the pace of ecosystem development.
The paper analyzes the role of digital transformation in the development of the ecosystem of Georgia, the main challenges, and the measures taken.
The work is based on the review of statistical data, the evaluation of the main directions of the anti-crisis policy of the state, and the government program 2021 - 2024 "for the construction of the European state."
The paper expresses opinions about the realization of the existing possibilities of digital transformation and the emergence of new perspectives in the development process of the startup ecosystem in Georgia.
АНАЛІЗ ВИРОБНИЧИХ МОЖЛИВОСТЕЙ РЕМОНТНИХ ПІДРОЗДІЛІВ СУХОПУТНИХ ВІЙСЬК ЗБРОЙНИХ СИЛ УКРАЇНИ ЗА ДОСВІДОМ РОСІЙСЬКО-УКРАЇНСЬКОЇ ВІЙНИ
Authors: Горбачова Яна , Сампір Олександр , Горбачов Костянтин
Published: May 2024

Аналіз умов виконання завдань ремонтними підрозділами Сухопутних військ Збройних Сил України (СВ ЗСУ) в ході російсько-української війни (РУВ) показав, що на якість і своєчасність проведення ремонту, крім забезпеченості військово-технічним майном та укомплектованості фахівцями-ремонтниками, значно впливає ступінь пристосованості місць його проведення [1-5].
DEVELOPMENT AND TRAINING OF LSTM MODELS FOR CONTROL OF VIRTUAL DISTRIBUTED SYSTEMS USING TENSORFLOW AND KERAS
Authors: Telezhenko Denys , Tolstoluzka Olena
Published: May 2024

This paper explores the development and application of a long-short-term memory (LSTM) model for virtual distributed system (VDS) control optimization using the TensorFlow and Keras frameworks. In the context of the rapid development of information technologies, the effective management of VRS resources becomes important for maintaining the scalability and performance of cloud computing and big data. The author focuses on the use of LSTM, a recurrent neural network, which has proven to be effective in detecting dependencies in time series and processing sequential data, which is critical for predicting the behavior of complex systems such as VRS. The process includes collecting and normalizing historical resource usage data, designing an LSTM architecture, training the model using TensorFlow, and implementing it using Keras to simplify the development process. An important stage is the assessment of the model's effectiveness through training and validation losses, as well as the assessment of the generalization ability of the model on test data. The results showed that the LSTM model effectively optimizes the management of HRS resources, reducing costs and increasing productivity. Analyzing the dynamics of training and validation helps identify and resolve overtraining issues, improving the generalization ability of the model. The article also discusses the possibilities of further research and the implementation of the model in real conditions, emphasizing the potential of LSTM in the development of innovative solutions for information technology.
OPTIMIZATION OF THE USE OF SOME MODULES IN THE MOODLE SYSTEM
Authors: Hubal Halyna
Published: May 2024

In the article, it is considered the modular object-oriented dynamic learning environment Moodle which provides a full-fledged and modern study of disciplines, including mathematical ones, satisfying the various needs of teachers and students in the interactivity and effectiveness of learning technologies, developing the ability to work with a large amount of information. The task of creating assignments with variants, which the teacher must grade manually, is implemented. Flexible settings of creating and visibility of assignment variants for students are presented.
МОТИВ НАУКИ У СЕРЕДНЬОВІЧЧІ У ПОВІСТІ НАТАЛЕНИ КОРОЛЕВОЇ «1313»
Authors: Потюк Софія
Published: May 2024

У статті розглянуто поетику представлення в історичній повісті Наталени Королевої “1313” образу Середньовіччя, який будується, зокрема, за допомогою дрібніших мотивів, що творять особливу художню реальність тієї епохи.
Серед таких мотивів, які формують макроконцепт Середньовіччя у повісті “1313”, можна виділити, зокрема, концепт диявола, концепт гріха, а разом із тим тісно пов’язаний із ними мотив науки в Середньовіччі. Продемонстровано, як у творі через поєднання доль вигаданих людей та реальних історичних діячів, твориться історія. Окреслено також виявлення паралелей образу вченого-ченця до “вічних” образів світової літератури; представлено контекст народження такого образу в творі про Середньовіччя; досліджено особливості поетики зображення мотиву науки.
ALZHEIMER TYPE 2 ASTROCYTOSIS IN HUMAN SEPSIS-ASSOCIATED ENCEPHALOPATHY
Authors: Shuliatnikova Tetiana , Tumanskyi Valerii , Tumanska Liubov
Published: May 2024

Sepsis-associated liver injury (SALI) with liver dysfunction/failure acts as a frequent component of MODS during sepsis and is characterized by hyperammonemia neurotoxic damage to the brain [1, 2].
РОЗВИТОК УКРАЇНСЬКОЇ АРХЕОГРАФІЇ ХІХ СТОЛІТТЯ У СВІТЛІ КУЛЬТУРНО-ІСТОРИЧНОГО ПІДХОДУ
Authors: Ковальчук Оксана
Published: May 2024

Історія української археографії – тема, що неодноразово досліджувалася вітчизняними істориками. Є десятки робіт з історії археографічних установ, едиційного стилю окремих істориків, репертуару тощо. Особливий напрямок складають дослідження, що охоплюють широкі часові й просторові межі. З історії української археографії ХІХ ст. існує три роботи у вигляді дисертацій. Це дослідження Б. Ватулі, О. Журби і В. Хмарського. З них лише робота Б. Ватулі охоплює основні археографічні об’єкти, що існували протягом ХІХ ст. на всій території України. Невелика кількість досліджень зумовлена трудністю підбору методики об’єднання розрізнених фактів у єдину систему. Особливо важко пояснити хід розвитку теоретичної частини, оскільки, протягом ХІХ ст. українська археографія фактично не продукує окремих досліджень про предмет, метод, завдання археографії, елементи археографічного оформлення. Проте існує багато ситуативних, зроблених під конкретні едиційні завдання правил видання історичних документів, дискусій, рецензій збірників джерел, згадки про базові поняття археографії в контексті висвітлення проблем історіографії та архівознавства. Зрештою, є самі видання історичних джерел, що завдяки аналізу дозволяють скласти уявлення про базові засади археографії. Ці матеріали вказують на зміни, що відбуваються протягом ХІХ ст. в осмисленні змісту археографії, та її ролі в історичному дослідженні.
КУЛЬТУРНІ ПРАКТИКИ ОРГАНІЗАЦІЇ ТА ФУНКЦІОНУВАННЯ КРЕАТИВНИХ КЛАСТЕРІВ ЄВРОПЕЙСЬКИХ МІСТ (ПОДОРОЖНІ НОТАТКИ ПО ПАРИЖУ)
Authors: Шевченко Маргарита , Овчаренко Тетяна
Published: May 2024

Стаття є культурологічним оглядом та дослідженням з питання організації культурного міського простору. Сучасний військовий стан в Україні спонукав громадян шукати безпечні міста для життя та професійного зростання. Позитивним є той факт, що можна вільно спостерігати, досліджувати та «входити в чужу» культуру безпосередньо та іноді, безкоштовно. Проблеми урбанізації та створення бренду міста стали актуальними не тільки для України, а й для всього європейського середовища. Мета дослідження – збір інформації та обмін досвідом щодо створення креативних кластерів міста. Методами дослідження ми обрали наступні: метод «включеного» спостереження, метод експерименту, аналіз культурних текстів та артефактів. Було визначено та проаналізовано досвід розвитку кластерів креативних індустрій у Парижі, а саме у департаменті Сен-Сен-Дені. В результаті дослідження дійшли таких висновків: ключову роль у  формуванні креативних просторів міста відіграє як позиція регіональної влади, так і стартапи підприємців, які активно заохочують розвиток креативних індустрій.
Sentimental Analysis and Social Media
Authors: K Sowmya , . Sathvik , N Shashank K , T Shreejesh , Shetty Sudeep M
Published: May 2024

In an era characterized by the digital revolution and the widespread adoption of social media platforms, analysing user sentiments online has become essential for grasping public opinion, consumer preferences, and emerging trends. This project delves into sentiment analysis within social media, employing web scraping techniques to gather and evaluate data from diverse online platforms. The central aim of this project is to uncover valuable insights and trends by systematically examining user sentiments. With social media’s pervasive influence, individuals and organizations now communicate, share information, and express opinions in unprecedented ways. This abundance of user-generated content presents a unique opportunity to access a vast repository of data that can offer meaningful insights. Sentiment analysis, also referred to as opinion mining, provides a means of understanding and categorizing the emotions, attitudes, and opinions expressed in online content. This project showcases the potential of data-driven approaches in making informed decisions and gaining a competitive advantage in today’s digital landscape.
Fourier Analysis of Signal Dependent Noise Images
Authors: Heine John , Fowler Erin , Schabath Matthew B
Published: May 2024

An archetype signal dependent noise (SDN) model is a component used in
modeling image acquisition systems. This component may share properties
with stationary normal white noise (WN). The characterization of WN
images was used as a reference for making comparisons with SDN in both
the image and Fourier domains (FDs). The image domain (ID) wavelet
expansion was applied to WN images (n = 1000). Expansion-image
orthogonality conditions were used to model and characterize the
variance decomposition in both domains. Aside from the wavelet analysis,
FD components of WN were characterized with summarized distributions and
probability density function modeling. SDN was constructed by either
multiplying simulated mammograms (i.e., stochastic images with
1/f power spectra) or clinical mammograms (both with
n = 1000) with WN. SDN was analyzed with the same techniques applied to
WN. The variance decomposition for WN decreases exponentially as a
function of the ID wavelet expansion level as did SDN; expansion images
for both types of noise were distributed similarly in the Fourier plane.
Theoretically, the Fourier transform of normal WN produces a complex
normally distributed image in the FD with a uniform power spectrum
distributed exponentially; SDN has similar attributes. These findings
are counterintuitive as SDN can be nonstationary in the ID but have
stationary attributes in the FD.
Gene expression profiling of p53 and c-myc in HTLV-1 positive blood donors in Congo
Authors: Iloukou Patrina Joseph , Boumba Anicet L.M. , Pouki Freddy S. , Massengo Norvi R. B. , Takale Ragive P. , Moukassa Donatien , Ennaji Moulay M.
Published: May 2024

Objectives. The HTLV-1 infection persists for life, remaining as asymptomatic viral reservoirs in most patients, ensuring the chain of transmission, but around 4% develop adult T-cell leukemia/lymphoma (ATLL). HTLV-1 is an oncogenic retrovirus that transforms CD4+ T lymphocytes and deregulates the lymphoproliferative pathways that contribute to the development of ATLL. To achieve cell transformation, most oncogenic retroviruses use proto-oncogene capture transduction, with proviral integration disrupting the expression of tumor suppressors or proto-oncogenes.
The aim. We conducted this study on the prevalence of HTLV-1 infection in blood donors to expand the HTLV-1 database, assess the risk of transmission via blood products, as well as evaluate the risk of persistent infection or development of neoplastic diseases in HTLV-1 carriers.
Materials and methods. This is a cross-sectional study of blood donors of all categories. For this study, 265 blood donors were recruited at the Centre National de Transfusion Sanguine in Brazzaville. After testing for HTLV-1 antibodies by ELISA, proviral DNA was extracted from all ELISA-positive samples for detection by nested PCR, followed by RT qPCR using specific primers p53 and c-myc for gene expression.
Results. 20/265 were positive for anti-HTLV-1 antibody, 5 donors were positive for proviral DNA. The prevalence of HTLV-1 was 1.8%. All HTLV-1-positive donors were male (1.8%), with a positive correlation (p = 0.05); the 1.1% of positive donors were regular, with the majority aged between 31 and 45 years (1.5%), and concubine donors were the most frequent (1.1%). All samples showed normal expression of the p53 and c-myc genes.
Conclusion. The prevalence, though low, remains a serious problem. No abnormal p53 or c-myc gene expression was detected in HTLV-1-positive donors, which could mean that none of the T lymphocytes in these donors had been transformed by HTLV-1.
Detection rates and high concentration of herpesvirus (Orthoherpesviridae) DNA in autopsy materials from patients with COVID-19 fatal outcome
Authors: Yurlov Kirill I. , Yakushina Sofia A. , Fedorova Natalya E. , Kisteneva Lidiia B. , Kelly Elena I. , Kanibolotsky Alexander A. , Ivkin Yevgeniy N. , Antipiat Natalia A. , Turin Igor N. , Larichev Victor F. , Demidova Natalia A. , Lesnova Ekaterina I. , Klimova Regina R. , Masalova Olga V. , Kushch Alla A.
Published: May 2024

Introduction. SARS-CoV-2 infection causes immune disorders that create conditions for the reactivation of human herpesviruses (HHVs). However, the estimates of the HHVs effect on the course and outcome of COVID-19 are ambiguous.
Аim – to study the possible relationship between the HHV reactivation and the adverse outcome of COVID-19.
Materials and methods. Postmortem samples from the brain, liver, spleen, lymph nodes and lungs were obtained from 59 patients treated at the Moscow Infectious Diseases Hospital No.1 in 2021–2023. The group 1 comprised 39 patients with fatal COVID-19; group 2 (comparison group) included 20 patients not infected with SARS-CoV-2 who died from various somatic diseases. HHV DNA and SARS-CoV-2 RNA were determined by PCR.
Results. HHV DNA was found in autopsy samples from all patients. In group 1, EBV was most often detected in lymph nodes (94%), HHV-6 in liver (68%), CMV in lymph nodes (18%), HSV in brain (16%), VZV in lung and spleen (3% each). The detection rates of HHVs in both groups was similar. Important differences were found in viral load. In patients with COVID-19, the number of samples containing more than 1,000 copies of HHV DNA per 100,000 cells was 52.4%, in the comparison group – 16.6% (p 0.002). An association has been established between the reactivation of HSV and HHV-6 and the severity of lung damage. Reactivation of EBV correlated with increased levels of liver enzymes.
Conclusion. Reactivation of HHVs in patients with fatal COVID-19 was associated with severe lung and liver damages, which indicates a link between HHV reactivation and COVID-19 deaths.
Prevalence and genetic diversity of the Alongshan virus (Flaviviridae) circulating in ticks in the south of Eastern Siberia
Authors: Kartashov Mikhail Yu. , Krivosheina Ekaterina I. , Kurushina Valentina Yu. , Moshkin Alexander B. , Khankhareev Sergey S. , Biche-ool Choigana R. , Pelevina Oksana N. , Popov Nikita V. , Bogomazova Olga L. , Ternovoi Vladimir A.
Published: May 2024

Introduction. Tick-borne infections are of great importance for many regions of Russia, including Eastern Siberia. This unfavorable epidemiological situation can be characterized not only by the circulation of well-known tick-borne infections, but also by the identification of new pathogens, the role of which remains little or generally unexplored. Multicomponent flavi-like viruses can cause infectious diseases in humans and pose a threat to public health.
The purpose of the study was the identification and molecular genetic characterization of the Alongshan virus (Flaviviridae, ALSV) isolates, transmitted by ticks in the south of Eastern Siberia.
Materials and methods. Total 1060 ticks were collected and analyzed from the territory of the Republics of Khakassia, Tuva, Buryatia, Irkutsk Region and Transbaikal Territory (Zabaykalsky Krai) in the spring-summer period 2023. ALSV RNA was detected by RT-PCR followed by nucleotide sequence determination and phylogenetic analysis for each segment of the genome.
Results. The ALSV infection rate in Ixodes persulcatus ticks collected in the Republic of Khakassia was 3.3% (95% CI: 1.4–7.5); in Irkutsk Oblast – 1.0% (95% CI: 0.3–3.7); in the Republic of Tuva – 0.9% (95% CI: 0.3–3.4) and in Transbaikal Krai – 0.7% (95% CI: 0.2–3.6). Sequences of all four segments of ALSV genetic variants circulating in I. persulcatus ticks in the south of Eastern Siberia are grouped with sequences found in China and clustered into the Asian subgroup transmitted by taiga ticks. The level of difference in the nucleotide sequences of genome fragments among the identified genetic variants of ALSV ranged from 2 to 3%.
Conclusion. The article shows the widespread distribution of ALSV in I. persulcatus ticks in the Republics of Khakassia and Tyva, Irkutsk Oblast and Transbaikal Territory. The obtained data actualize monitoring of changes in the area of distribution of potentially dangerous for humans flavi-like viruses and their vectors.
Development, production and characterization of SARS-CoV-2 virus-like particles (Coronaviridae: Orthocoronavirinae: Betacoronavirus: Sarbecovirus)
Authors: Latyshev Oleg E. , Zaykova Olga  N. , Eliseeva Olesya V. , Savochkina Tatyana E. , Chernoryzh Yana Yu. , Syroeshkin Anton V. , Petrov Gleb V. , Vorkunova Galina  K. , Larichev Victor F. , Fediakina Irina T. , Cherepushkin Stanislav A. , Tsibezov Valeriy V. , Yuzhakova Ksenia A. , Kulikova Nadezhda Yu. , Lebedeva Varvara V. , Yakunin Dmitriy Yu. , Kozlova Alina A. , Baranets Marina S. , Yurlov Kirill I. , Lesnova Ekaterina I. , Grebennikova Tatyana V.
Published: May 2024

Introduction. The COVID-19 pandemic caused by SARS-CoV-2 has created serious health problems worldwide. The most effective way to prevent the occurrence of new epidemic outbreaks is vaccination. One of the modern and effective approaches to vaccine development is the use of virus-like particles (VLPs).
The aim of the study is to develop a technology for production of VLP based on recombinant SARS-CoV-2 proteins (E, M, N and S) in insect cells.
Materials and methods. Synthetic genes encoding coronavirus proteins E, M, N and S were used. VLP with various surface proteins of strains similar to the Wuhan virus, Delta, Alpha and Omicron were developed and cloned into the pFastBac plasmid. The proteins were synthesized in the baculovirus expression system and assembled into VLP in the portable Trichoplusia ni cell. The presence of insertion in the baculovirus genome was determined by PCR. ELISA and immunoblotting were used to study the antigenic activity of VLP. VLP purification was performed by ultracentrifugation using 20% sucrose. Morphology was assessed using electron microscopy and dynamic light scattering.
Results. VLPs consisting of recombinant SARS-CoV-2 proteins (S, M, E and N) were obtained and characterized. The specific binding of antigenic determinants in synthesized VLPs with antibodies to SARS-CoV-2 proteins has been demonstrated. The immunogenic properties of VLPs have been studied.
Conclusion. The production and purification of recombinant VLPs consisting of full-length SARS-CoV-2 proteins with a universal set of surface antigens have been developed and optimized. Self-assembling particles that mimic the coronavirus virion induce a specific immune response against SARS-CoV-2.
PLATAFORMAS ADAPTATIVAS COMO RECURSOS PEDAGÓGICOS
Authors: Froes Carla Baggio Laperuta , Kimura Débora da Paz Maciel , Graf Lucimar , Farias Sueli Cirilo
Published: May 2024

As Plataformas Adaptativas são estratégias e recursos que tendem assegurar a aprendizagem de alunos que necessitam de ajuda educacionais, onde o docente planeje atividades que articulem o aprendizado do educando. Além disso, este artigo aborda o Ensino Híbrido que ficou muito conhecido depois da pandemia. O Ensino Hibrido com as Plataformas Adaptativas tem como foco principal de criar inúmeras características de aprendizagens para diversos alunos em ambiente virtual ou em sala de aula. As tecnologias evoluíram muito com o passar dos anos, através de muitas reformulações educacionais. Todo este processo educacional é um planejamento direcionado para o aluno, intermediado pelo professor, através das plataformas adaptativas e com o uso das novas tecnologias, o ensino tornar-se importante para ambos. Diante disso, é importante estudar os diversos aspectos das plataformas adaptativas com o ensino híbrido, onde o educando evoluía suas competências e habilidades a frente dos conteúdos ministrados.
Pengembangan Brosur sebagai Sumber Pengetahuan bagi Masyarakat tentang Jenis Tumbuhan Obat Tradisional
Authors: Yudi Yudi
Published: May 2024

Brochures are a medium for conveying information to the general public in written form. The main aim of this research is to develop a brochure to be used as a source of knowledge for the public about types of traditional medicinal plants. This type of research is development research. The development research in this research is making brochures for the community. The development model used is the 4D model developed by Thiagarajan et al. (1974) which consists of 4 stages, namely define, design, develop, and disseminate. However, in this research, the researcher modified it to 3D, namely define, design, and develop due to limited time and research level. The population for the development research was the entire community in Batu Bangka Village, Moyo Hilir District, Sumbawa Besar Regency. The sample for the development research was 15 people in Batu Bangka Village, Moyo Hilir District, Sumbawa Besar Regency. The data collection techniques used are validation, readability testing, and documentation. Based on the research that has been carried out, it was found that the validation results for content/material experts were 82% with very good qualifications, the validation results for language experts were 85% with good qualifications, and the validation results for display experts were 80% with good qualifications. Meanwhile, the highest public readability test results were 82% and the lowest public readability test results were 70%, so it can be said to be suitable for dissemination to the public.
Comparative Physiological Study of Pancreas in Eurasian Collared Dove (Streptopelia Decaocto) and Buzzard (Beuteo Beuteo Vulpinus)
Authors: Hamad Ranin Saffaa , Hamza Ekhlas Abid
Published: May 2024

Background: Domestic dove, often known as city dove or rock dove, is a subspecies of the rock dove. Domesticated birds began with dove. The massive buzzard (Buteo buteo) inhabits in many ecosystems across the globe. The Accipitridae family and Buteo genus include it. Buzzards hunt and eat alone, however they may gather in flocks during migration or when food is plentiful. Aim to study: The aim of this research to comparative physiological study of pancreas in collared dove (Sterptopelia decaota) and Buzzard (beuteo vulpinus). Methods: This research employed 10 healthy adult Dove (Streptopelia decaocto) and buzzard (Beuteo beuteo vulpinus) per feeding method. Babylonian tradesmen traded birds. These birds of each species for used on the physiological studies. Results: Mean insulin, glucagon, and somatostatin levels in Buzzard and Dove were compared, and the findings indicated a substantial difference. Buzzard had a higher mean insulin level difference (603.59 ± 25.0) than Dove (414.73 ± 29.2). However, buzzard had a higher mean difference in glucagon levels (373.80 ± 16.3) compared to Dove (303.65 ± 32.3). Additionally, Buzzard had a higher mean difference in somatostatin levels (454.89 ± 24.1) compared to Dove (368.80 ± 28.6). Conclusion: The results showed that insulin, glucagon, and somatostatin were all significantly different from one another.
Cooperative Society: A Veritable Tool for Wealth Creation and Poverty Alleviation in Bayelsa State
Authors: Akarara Akarara , Azebi Azebi , Innocent Oyeinbrakemi , Ayebaemi Ebierinyo
Published: May 2024

Concerns have also been raised about cooperative organisations' efforts to reduce poverty and generate wealth in the communities in which they operate. Most cooperatives fail to achieve their goal of enhancing members' financial security and well-being, which ultimately results in their dissolution. Thus, this study looked at how cooperative societies in Bayelsa state contribute to wealth development and poverty reduction. In order to accomplish its goals, the study employed a survey research methodology with a structured questionnaire, which was analysed using chi-square and basic descriptive statistics. The study's findings showed that cooperatives help members acquire assets both directly and indirectly (in the form of cash or in kind). The support of cooperative society has enabled the acquisition of a variety of assets, including buildings, cars, gadgets, and land. This helped each member achieve their needs for safety and physiology while also improving the people's economic situation. Members who gained assets after they satisfied their fundamental needs were able to transcend extreme poverty. Asset acquisition is a physical economic progress. Here, cooperatives function as both major contributors to and agents of poverty alleviation. Therefore, in order for cooperative society activities to continue having a good influence on the livelihood of its members in Bayelsa state, it is advised that they be appropriately governed by the government and the relevant agencies.
Breast Cancer Induced by Radiotherapy Following Hodgkin's Disease: A Study of Four Cases and Literature Review
Authors: Benyahia Radia , Mazouzi Chahira , Hail Kamel , Keboua Asma , Benghanem Lounes
Published: May 2024

Radiotherapy is a cornerstone in the treatment of Hodgkin's disease but can have long-term consequences, notably the development of secondary malignant tumors. This case study and literature review highlight the imaging characteristics, diagnostic challenges, and clinical outcomes of this late complication. The aim of this article is to underscore the role of imaging modalities in the diagnosis, characterization, and management of this rare and complex condition. We discuss the radiological findings, clinical diagnosis, and therapeutic considerations, thereby providing valuable insights into radio-induced breast cancer in Hodgkin's disease and emphasizing the importance of personalized surveillance in these high-risk patients.
STUDI STABILITAS FORMULASI SELF NANO EMULSIFYING DRUG DELIVERY SYSTEM (SNEDDS) EKSTRAK DAUN SERUNAI SEBAGAI ANTI DIABETES DENGAN VARIASI KONSENTRASI ASAM OLEAT
Authors:   Universitas Sari Mulia, Norliani Rahma , Noval Noval , Melviani Melvianii
Published: May 2024

Management of diabetes mellitus can use chemical drugs and traditional medicine. One of the medicinal plants used by the community is chrysanthemum leaves (C.Odorata). The use of traditional medicine still has drawbacks, one of which is that its pharmacological effects are relatively weak and slow, affecting bioavailability and the therapeutic effect is not optimal. The aim of the study was to determine the stability of the formulation of the SNEDDS of chrysanthemum leaf extract as an anti-diabetic agent and to determine the effect of variations in the concentration of oleic acid in the formulation of the SNEDDS on evaluation and stability testing. This research method uses the Quasy Experimental Design method. The simplicia was made into an extract and then made into a nanoemulsion preparation with varying concentrations of oleic acid. The results of this study in the centrifugation test were stable at F3. Unstable hot-cold and freeze-thaw cycle tests. Stable resistance to dilution test at F2 250 ml. Week 0 and 4 accelerated storage tests were stable on F3 and F1. The evaluation results showed that variations in the concentration of oleic acid had no effect on particle size and PDI values ​​but had an effect on the transmittance value (%) as shown in the One Way Anova statistical analysis (p<0.05). The evaluation results showed that F2 with 10% oleic acid concentration was a stable formula because it had the smallest particle size and PDI (Polydispers Index) value.
PENGEMBANGAN TRANSDERMAL DRUG DELIVERY SYSTEM (TDDS) PATCH METHYLDOPA SEBAGAI ANTIHIPERTENSI PADA KEHAMILAN
Authors:   Universitas Sari Mulia, Mayna Mayna , Noval Noval , Khairunnisa Aisya Fitri , Octaviani Olivia , Wilujeng Wilujeng
Published: May 2024

Hypertension in pregnancy including chronic hypertension with or without pre-eclampsia, gestational hypertension increases maternal and infant mortality significantly. The treatment for hypertension in pregnancy is the administration of methyldopa. Methyldopa transdermal patch is made by mixing the polymer first and then adding the active substance, namely methyldopa drug. It is intended that the polymer becomes an outer layer that controls the release of the drug. The resulting transdermal patch formulation was then evaluated, including organoleptic test, pH test, weight uniformity test, patch thickness test, folding resistance test, moisture test and penetration test using Franz diffusion cell. SPSS statistical data analysis. The penetration rate results showed F1 with 832.16 µg/cm2, F4 with 767.95 µg/cm2, F2 with 2819 µg/cm2 and F3 with 275.38 µg/cm2 all formulas have met the requirements. Based on the results of physical characteristics evaluation research, all formulas have met the requirements. The results of the in vitro evaluation of the methyldopa patch transdermal penetration test found that the difference in concentration in each formula had no significant effect on the penetration test. Based on physical evaluation parameters and in vitro penetration tests, the most optimal formula is F4 with the ratio of HPMC and ethyl cellulose (300:100) seen by fulfilling all physical characteristic evaluation tests and having a constant percent of cumulative amount to rise.
EFEKTIVITAS EKSTRAK ETANOL DAUN BINAHONG (Anredera cordifolia Steen.) SEBAGAI ANTIDIABETES PADA MENCIT (Mus muculus. L)
Authors:   Program Studi Diploma III Farmasi Akademi Farmasi Indonesia Yogyakarta, Stevani Anggita Nadia , Rissa Mexsi Mutia
Published: May 2024

Diabetes Mellitus is a disease with lifelong treatment, while antidiabetic drugs consumed can cause side effects in the long term, so it requires alternative therapies with traditional medicinal plants such as the binahong plant (Anredera cordifolia (Ten) Steen.) which contains flavonoids and saponins. These compounds have the ability to lower blood sugar levels. This study aims to determine the antidiabetic effect of the ethanol extract of binahong leaves on alloxan-induced swiss male males. This type of research was experimental with the method of pre and post test with controlled group design, using 15 male swiss strains which were divided into 3 groups. Negative control (CMC Na 0.5%), positive control (Glibenclamide dose 0.65 mg/KgBB), and the treatment group ethanol extract of binahong leaves dose 17.5 mg/KgBB. Data on blood sugar levels obtained were analyzed using SPSS 23 with a 95% confidence level. The results of this study showed that the ethanol extract of binahong leaves at a dose of 17.5 mg/kg could reduce blood sugar levels in alloxan-induced swiss male mice. Data on decreasing blood sugar levels obtained were analyzed by One Way ANOVA, followed by LSD. The test results showed that the decrease in blood sugar levels in mice given the ethanol extract of binahong leaves at a dose of 17.5 mg/KgBW was not significantly different from that given by glibenclamide at a dose of 0.65 mg/KgBW (sig > 0.05).
Social inclusion in cultural participation: a systematic review
Authors: Merino Orozco Abel , Di Giusto Valle Cristina , Saez Velasco Sara
Published: May 2024

This work presents a systematic review aimed at addressing exclusion in cultural access, particularly for socially and/or intellectually vulnerable groups, in order to contribute to social inclusion and active participation. It aims to diagnose exclusion factors, reflect on inclusion models, understand culture's role in identity restructuring and autonomy, and identify best practices in intellectual and social accessibility. An exhaustive search was conducted in the Web of Science and Scopus databases, delving into 37 selected studies. These studies were categorized into five areas of analysis: Access to culture for people with disabilities, Cultural policies and participation (barriers and facilitators), Health and/or well-being and cultural participation, Cultural diversity and participation, and Access to culture for all. The main conclusions of the work emphasize the dynamization of inclusive and accessible policies as fundamental pillars for an equitable society, which have an impact on improving public health, well-being, and the construction of cultural identities.
Economic and Humanistic Burden of Moderate and Severe Hemophilia A and B in Spain: Real-World Evidence Insights from the CHESS II Study
Authors: Peral Carmen , De Lossada Juste Alfonso , Lwoff Nadia , Espinoza-Cámac Nataly , Casado Miguel Ángel , Burke Tom , Alvir Jose , Thakkar Sheena , Ferri Grazzi Enrico
Published: May 2024

Background: Hemophilia is a congenital disorder characterized by deficiency or absence of clotting factor VIII in hemophilia A (HA) or clotting factor IX in hemophilia B (HB), resulting in frequent, repeated, and prolonged spontaneous or traumatic bleeding into joints or soft tissue. Severity is classified by the patient’s baseline level of clotting factor activity as mild (>5%-40%), moderate (1%-5%), or severe (<1%). In Spain, there is limited information on the societal economic burden of disease.

Objective: To estimate the economic and humanistic burden of disease in adult patients with non-inhibitor moderate and severe HA and HB in Spain.

Methods: Spanish data from the CHESS II study (2018-2020) on patients’ clinical characteristics, health-related quality of life (HRQoL) and hemophilia-related healthcare resource utilization were analyzed. Economic burden was determined by estimating condition-related annual per-patient direct (medical and nonmedical) and indirect costs, stratified according to hemophilia type and severity and presented as 2022 Euros. HRQoL was assessed via the EQ-5D-5L.

Results: Of 341 patients in the Spanish CHESS II cohort, 288 patients met the inclusion criteria: 181 had HA (37% [n = 66] moderate and 63% [n=115] severe) and 107 had HB (26% [n = 28] moderate and 74% [n = 79] severe). Mean annual direct cost was higher in HB than in HA, and higher in severe than in moderate patients, resulting in an annual cost/patient of €17 251 (moderate HA), €17 796 (moderate HB), €116 767 (severe HA) and €206 996 (severe HB). The main direct cost component in all groups except moderate HA was factor replacement therapy. Mean per-patient indirect cost was €4089 (moderate HA), €797 (moderate HB), €8633 (severe HA) and €8049 (severe HB). Finally, the mean total cost (direct and indirect) for moderate and severe patients were €91 017 (HA) and €163 924 (HB). EQ-5D-5L [SD] scores were lower in patients with severe HA (0.77 [0.18]) and severe HB (0.70 [0.22]) compared with patients with moderate HA (0.81 [0.15]) and moderate HB (0.86 [0.17]).

Conclusions: Independently of the type of hemophilia, greater condition severity was associated with increased costs and a decrease in HRQoL.
Exploring English Language Teaching at Dakhil Level in the Aliya Madrasas in Bangladesh
Authors: Ashraf Tasleem Ara
Published: May 2024

In Bangladesh, a large group of students study in the Aliya madra sas that provide both religious and secular education. According to the new curriculum, the students studying at the Aliya madrasas must learn English language from Ebtedayee level (primary) and continue until Kamil (masters) level. However, the reports from BANBEIS and World Bank (2015) have revealed that the English language proficiency of the students are below the standard. Therefore, this study is an attempt to explore the English language teaching and learning approaches applied at Dakhil level in Aliya madrasas. Dakhil level is considered equivalent to S.S.C or secondary level education in Bangladesh. Data for the study was collected using a mixed method that included a questionnaire survey, interviews and focus group discussion. A total 50 teachers and 200 students from ten Aliya madrasas participated in the survey. The major findings revealed that CLT methods were not properly implemented in the Aliya madrasas at Dakhil level. Lack of adequately trained teachers, backdated syllabus, lack of necessary teaching aids, large class size and prevalence of traditional language teaching methods have been identified as the major causes for the poor teaching and learning of English language at the Aliya madrasas in Bangladesh. Keywords: CLT, Aliya Madrasa, Dakhil level, ELT, NCTB, English for Today
O DIREITO DE ACESSO À ÁGUA POR ESFORÇOS DE GOVERNANÇA NAS AÇÕES DE PREVENÇÃO AO CORONAVÍRUS: UMA ANÁLISE COM BASE NO EXEMPLO DO DISTRITO FEDERAL
Authors: Garcia B. Lima Moraes Gabriela , Borges Carvalho Piauilino Bárbara
Published: May 2024

Este artigo aborda o direito de acesso à água no contexto da pandemia causada pelo novo coronavírus e se propõe a identificar a garantia do acesso à água como mecanismo de prevenção contra a Covid-19, por uma análise de algumas das ações de política pública no Distrito Federal. Busca-se, ainda, analisar, diante da eventual lacuna governamental de garantia do acesso à água, a existência de iniciativas privadas no Distrito Federal, em um contexto de governança. Utilizou-se tanto o método de pesquisa quantitativo, por meio da coleta e análise de dados, quanto o qualitativo, mediante revisão normativa e bibliográfica. A partir do estudo realizado, foi possível perceber que o abastecimento de água no Distrito Federal se dá de maneira desigual entre as regiões administrativas, apontando para menor percentual de abastecimento na periferia. Diante da crise sanitária enfrentada, o acesso à água ressaltou a relevância desse direito como garantidor da vida. Frente à lacuna governamental, destacou-se a atuação da sociedade civil e de instituições não governamentais no enfrentamento ao novo coronavírus nas regiões do DF que carecem de acesso à água, sendo possível observar uma preocupação em prol das pessoas mais vulneráveis no contexto da pandemia.
On the problem of interpretation, understanding and realisation of system-activity approach in school education
Authors: Alekseeva L. V.
Published: May 2024

The author focuses on the problem of interpretation and understanding of the system- activity approach in education. The author carries out a critical analysis of the author's vision of this approach by A.G. Asmolov, as well as interpretations of the system-action-activity approach in modern education, which has become the methodological basis of FSES and has changed the system of education in general education school, the consequences of erroneous interpretation of which have had a negative impact on the results of learning, manifested in the decline in the quality of school education.
The dialogue between languages of painting and cinema in The Age of Innocence by Martin Scorsese
Authors: V. Tarasova Maria
Published: May 2024

After a short survey of the key theories that define the intermediality of film and the relationship between cinema and painting, the paper focuses on the case study of The Age of Innocence, a film by Martin Scorsese that exemplifies the transformations cinematic imagery may undergo under the influence of painting. Methodologically grounded in the linguistic theory of correlation between objective and subjective language systems, which cooperate in producing each utterance, the research approaches painting as a multifaceted objective language that cinema employs to reference specific worldviews or models of the world. Comprehension of the analogies between painting and film sheds light on how and why cultural patterns from other art are recreated in new media, and how the subjective language of the work of cinematic art is formed in relation to the objective languages of other visual arts. The results of the analysis reveal the film as an intertext with various genres and styles of European painting embedded into its visual language system. Specifically, the paper reveals how the Netherlands’ Golden Age portraiture, landscapes, and still-lives, together with several forms of the Impressionism and Art Nouveau styles, compose the objective language of the film. This research contributes new empirical ground to the theoretical studies of the interconnectedness of cinema and painting, providing a wider perspective on the universal language of visual art.