bluuebunny/crossref_metadata_2025 huggingface dataset:
Marketing strategy at transport enterprises in the context of crisis management.
Authors: Kravchenko Maryna , Kinash Alina
Published: February 2020

The article is devoted to the research of issues, analysis and improvement of marketing activities at the railway enterprises of Ukraine. As a result of the research, it was established that in difficult and unstable financial business conditions, and under competition, there is a need to adopt marketing management methods at railway enterprises. The article discusses scientific approaches to the problems of marketing development in the service sector. Also It is revealed the essence of the concept of transport services as an object of marketing activities. The methodological foundations of the marketing assurance of the quality of transport services and the applying of logistic methods in the implementation of the marketing management concept in anti-crisis situations in the field of transport services are defined. The analysis of freight traffic by various types of transport, as well as specifically considered the transport by rail. The main problems of railways and the quality of services, lack of customer service flexibility, weak interaction with other transport processes are identified. Considered and improved the scheme of the exit of the enterprise from the crisis state, and also considered the factors of risk development of the enterprise in the anti-crisis period. Recommendations are given to improve marketing activities in the structure of enterprise management, which allow planning and coordination of marketing activities in rail transport, and you can calculate the optimal distribution of goods using formula and calculations, you can determine the delivery and processing for unplanned goods, and the proposed approach will allow go from planning, receiving applications for shippers in the optimum time.
Theoretical aspects of enterprise competitiveness.
Authors: Mamatova Leila , Pozhydaieva Anna
Published: February 2020

The article deals with the theoretical aspects of competition and competitiveness of the enterprise. The economic essence of the concept is revealed, the criteria and indicators of competitiveness assurance are determined, the factors of influence are identified. It is determined that the effective restructuring of the Ukrainian economy should be focused on the perfect use of existing intellectual potential or attraction of highly qualified, and the corresponding development of high-tech production and innovation potentials. It is proposed to define the term "enterprise competitiveness" as a comprehensive comparative characteristic of a possible level of a set of key success factors with an appropriate assessment of the enterprise's capabilities in a particular segment of the market and for a certain period of time in accordance with a similar set of indicators of a competing enterprise. It is generalized that it is the competitiveness of the enterprise that forms its own positioning in the competition, the position on the market and is possible only by the achievement and development of relevant competitive advantages in the economic, technical and organizational directions of activity of the entity.
Innovative marketing in the В2В market.
Authors: Gonchar Vіktorіya , Bogachov Oleksii
Published: February 2020

Innovation is an iterative process based on the perception of a new product or new service technologies based on the invention. Innovation is characterized by four parameters: type, level, location and effect. In terms of level, innovations can be radical or additional. Analysis of the introduction of radical innovation has proved that disruptive innovation begins in one of two types of niche markets. The first, low level of the market, where there is an opportunity to dominate this segment first, and then to disrupt the rest of the market by drawing up functions and raising prices. The second type, the principle of high-class innovation: start with a high price in the market, and then go down to the mass market, adding additional functions and reducing (instead of increasing) the price. It has been proven that the efficiency of diffusion of new technology is based on the paradigm of variable speed of innovation adoption. The first potential customers are divided into two segments: where possible to use the methods of technologies and behavioral grounds for purchasing an innovative product. In developing innovative products, getting feedback from consumers is the most important part on the road to success. For both segments, the most appropriate way to collect information is to interview because depth of analysis is required. When the "type of innovative decision" is collective, the rate of adoption is lower than that of the individual. This makes the dissemination of ideas in the B2B sector more difficult as decisions are made at the organization level. It is recommended to consider the four components that allow the marketing program to be effective. An important part of the process of innovative marketing in B2B is understanding the decision-making process of its main participants. Identify 5 types of people who play a role in the decision-making process in the purchase of a new product: users, influencers, buyers, deciders and intermediaries. Each type requires a specific targeting strategy as they are due to different reasons.
Organizational foundations of modern quality management systems in industrial enterprises.
Authors: Kravchenko Maryna , Kussa Roman
Published: February 2020

Given the fact that Ukraine is heading for the EU, then all regulatory documents related to certification, especially in industrial enterprises, must comply with standards and international norms. Therefore, improving the quality of products in Ukraine and this period is an important issue. The growth of competitiveness not only in the domestic market but also in the global one stimulates industrial enterprises to revise the quality standards of products. Improving the quality of products in Ukraine is dictated not only by high competitiveness in the domestic market, the quality of life of workers also directly depends on the quality of products, since quality products are sold at a higher price, and this is the salary of industrial workers and their social well-being. Also, the high quality of products of industrial enterprises and manufacturing according to modern technologies indicates the country's level in the competitive list of countries, and this is the image of the state as an exporter on the international market. The guarantor of product quality of industrial enterprises in the international market are the ISO 9000 series standards. Due to the fact that the scientific and economic achievements of new markets in competitiveness, the implementation of innovative solutions and inventions, lead to the formation at industrial enterprises of a unified system of actions to improve the quality and level of knowledge, which become one of the main conditions for the development and growth of competitiveness of the economy enterprises, industries but also the state. A study of the development of scientific theories of quality management at industrial enterprises and their approaches to practical implementation revealed a number of methodological foundations and principles aimed at improving product quality management at industrial enterprises. Scientific research in this area has gone from theory based on the principles of marriage and theories of production process control. The topic is relevant especially at a time when the country is moving to international standards and entering the international market for products. The study and implementation of international standards is relevant in this period at industrial enterprises.
Formation of an effective mechanism for motivating the work of the management personnel of the organization.
Authors: Aleksandrova Raisa
Published: February 2020

In the presented article, some issues of the motivational mechanism of personnel management and management personnel in particular are considered: the role of motivation, the nature, functions and methods of evaluating the effectiveness of the mechanism of motivation of managers' work.  It is determined that the basis for building a motivational mechanism are the needs and motivation. Needs force a person to act, and motivation is the driving force that manifests, directs and stores his purposeful efforts. The motivational mechanism underlies the successful existence of any enterprise, since it contributes to the rational use of the labor potential of workers, the mobilization of their mental and physical capabilities and leads to high productivity. A study of the mechanism of motivation of staff in the existing commercial enterprise showed that, mainly, in managing the current activities of the enterprise, administrative-organizational methods. Economic methods of material incentives for workers in the form of bonus labor results are used, but their efficiency is low. The main indicators of enterprise activity have a positive development trend, however, a comparison of the growth rates of wages and labor productivity showed that wage increases do not stimulate the growth of labor productivity. This indicates a low level of labor motivation and the need to develop a more effective mechanism. The analysis and identified shortcomings in the system of labor motivation of management personnel allowed to determine the main directions of its improvement based on material and non-material incentives. A flexible system for calculating the auxiliary salary in the form of a premium is proposed, depending on the integrated indicator, which is formed on the basis of the performance of the subordinate team, self-assessment and expert evaluation. The proposed technique will allow an objective assessment of the work of managers and their contribution to the results of the company.
Research of key elements of the implementation of the occupational health and safety management system with the use of ISO 45001.
Authors: Belous-Sergeeva Svetlana
Published: February 2020

The Occupational Safety and Risk Management system is an important part of an organization's health and safety strategy. Companies that have their own health and safety management system certified to ISO 45001 benefit from international recognition of ISO standards. Certification makes it possible to standardize the requirements for occupational safety management in a global context, provides companies with greater legal certainty, minimizes risks. The work has an overview character. The purpose of the article was to identify and analyze the key elements of ISO 45001 for its successful integration into the existing OSH management system of Ukrainian organizations. The paper examines the requirements of ISO 45001: 2018. It identifies the basic processes that will help organizations to actively increase the effectiveness of their work in the field of occupational safety. The main advantages are highlighted, which will promote the reputation of the organization as a safe place to work and help to gain more direct benefits in the industry. The list of key factors for successful implementation and maintenance of the system of management of health and safety at work has also been formed. Research findings are an important tool for any company interested in implementing or upgrading a health and safety management system using the ISO 45001 standard, regardless of size and scope.
SOURCES OF HISTORY OF THE RULERS OF THE CHANCELLERY OF THE
TURKESTAN GOVERNOR GENERAL
Authors: Ergashev B.E.
Published: February 2020

This article is devoted to the issues of source study of the history of Turkestan in the second half of the 19th and beginning of the 20th centuries. The main object of study is the history of the rulers of the office of the Turkestan governor-general
EXAMPLES OF INTERDISCIPLINARY CONNECTIONS OF PHYSICS AND MATHEMATICS IN
LABORATORY WORKSHOP ON PHYSICS
Authors: Kucherenko Liliya Vladimirovna
Published: February 2020

The paper gives an example of the integration of knowledge based on the interdisciplinary connections of physics and mathematics when performing a laboratory workshop in physics
HIGH-VOLTAGE ELECTRIC CONDUCTIVITY OF RUBIDIUM DIHYDROPHOSPHATE AND ITS RELAXATION
Authors: Gadzhiev S.M. , Gadzhiev A.S.
Published: February 2020

The dependence of electrical conductivity on the electric field strength and relaxation processes in the proton solid electrolyte RbH₂PO₄ are investigated. With increasing electric field strength, the electrolyte conductivity increases in an attempt to the limiting value. The relative increase in conductivity and relaxation time with increasing temperature increase and reaches 208% at 600 K. The relaxation time is of the order of 104 s.
ORDER OF PLANETS IN THE SOLAR SPHERE
Authors: Aliev Andrei Sabirovich
Published: February 2020

The planets of the solar system, located on the periphery of the solar sphere, are located in a certain order and at a certain distance from the Sun. The more advanced the planet in its development, the closer its orbit to the Sun. Planets in the solar system undergo their seven-year planetary training. All the planets of the solar sphere are located in the same plane and turn around the Sun and together with the Sun in the same direction. This order and training exists in every cosmic sphere-school, be It large or Small spheres. There are laws and forces that maintain this cosmic order that modern astronomers and astrophysicists have no idea about. Hence the result: in our days, humanity does not know any movement of the Earth, no movement of the Sun, no movement of the electron.
RESPIRATORY TUBERCULOSIS AND CHRONIC OBSTRUCTIVE LUNG DISEASE - FEATURES
OF THE COMORBIDE STATE
Authors: Katicheva Anna Viktorovna , Brazhenko Nikolai Andreyevich , Brazhenko Olga Nikolaevna , Chuikova Anna Georgievna
Published: February 2020

In modern conditions, chronic tobacco intoxication and chronic obstructive pulmonary disease are widespread and affect the health and life expectancy of patients. Among patients with tuberculosis, chronic tobacco intoxication and COPD are also widespread. Against the background of smoking and chronic obstructive pulmonary disease in patients with tuberculosis of the respiratory system, bronchial obstruction, hypoxemia, impaired capillary pulmonary blood flow, and a decrease in the diffusion capacity of the lungs are determined. A comorbid state is accompanied by the development of oxidative stress, systemic inflammation, endothelial dysfunction. Such changes in combination with dyslipidemia contribute to the development of multifocal atherogenesis, systemic arterial hypertension and the rapid development of cardiovascular pathology
ANALYSIS OF THE DYNAMICS OF ENTRY IN ACTION OF RESIDENTIAL HOUSES IN URBAN AND RURAL AREAS IN RUSSIAN FEDERATION
Authors: Kulenzan A. L. , Marchuk N. A. , Talanova V. A.
Published: February 2020

The level of housing affordability shows the economic opportunities of the population, the strategic activities of the state aimed at improving the lives of citizens. In this article as object of research dynamics of volumes of the put into operation houses in urban and rural areas of the Russian Federation, and also dynamics of volumes of the houses constructed by the population at the expense of own and attracted means in an urban area was considered. The article considers the characteristics of basic and chain indicators. The forecast for 2020 of volumes of the entered housing is made.
Role of Cav3.2 Low-Threshold Calcium Channel in Mechanosensitivity and Neuropathic Pain
Authors: Chauveau T. , Kobakhidze N. , Weill Rossi R. , Winckler L.
Published: February 2020

Les fibres nerveuses peuvent être divisées en trois catégories, jouant chacune leur rôle dans différents types de sensations. Ces fibres ainsi que les récepteurs qu’elles expriment jouent un rôle crucial dans les pathologies liées aux perceptions thermiques, chimiques, nociceptives et mécaniques. Dans cette étude, les auteurs ont porté leur intérêt sur les fibres nerveuses Aδ et C, connues pour leurs rôles dans la mécanoception, et une sous-famille de ces fibres plus particulièrement, les fibres exprimant des récepteurs mécaniques à faible seuil d’activation (low-threshold mechanoreceptor or LTMRs). Sachant que les canaux calciques Cav 3.2, de type T, sont connus pour leur rôle dans la transmission d’informations sensorielles, leur prévalence ainsi que leur activité dans les LTMRs ont été évaluées via l’utilisation de souris génétiquement modifiées. Cette étude montre que les canaux Cav3.2 sont impliqués dans la transmission d’informations mécanique et thermique au froid, et donc potentiellement dans les douleurs neuropathiques. En outre, les canaux Cav3.2 ont été détectés le long des axones des fibres LTMRs, suggérant un rôle important de ces canaux dans la vitesse de conduction.
Editorial
Authors: McCarthy Conal
Published: February 2020

Museum Worlds: Advances in Research Volume 7 (2019) is an open issue, covering a rich variety of topics reflecting the range and diversity of today’s museums around the globe. This year’s volume has seven research articles, four of them dealing with very different but equally fascinating issues: contested African objects in UK museums, industrial heritage in Finland, manuscript collecting in Britain and North America, and Asian art exhibitions in New Zealand. But this issue also has a special section devoted to Barbara Kirshenblatt-Gimblett, which contains three articles and an interview.
A "Safe Space" to Debate Colonial Legacy
Authors: Zetterstrom-Sharp Johanna , Wingfield Chris
Published: February 2020

In February 2016, students at Jesus College, Cambridge voted unanimously to repatriate to Nigeria a bronze cockerel looted during the violent British expedition into Benin City in 1897. The college, however, decided to temporarily relocate Okukor to the University’s Museum of Archaeology and Anthropology. This article outlines the discussions that occurred during this process, exploring how the Museum was positioned as a safe space in which uncomfortable colonial legacies, including institutionalized racism and cultural patrimony rights, could be debated. We explore how a stated commitment to postcolonial dialogue ultimately worked to circumvent a call for postcolonial action. Drawing on Ann Stoler’s and Elizabeth Edwards’s discussions of colonial aphasia, this article argues that anthropology museums risk enabling such circumvention despite confronting their own institutional colonial legacies.
The Inertia of Collections
Authors: Martínez Francisco
Published: February 2020

The first aim of this article is to study the persistence of the collection’s positive presentation of Rosenlew’s industrial heritage, and the second is to anthropologically reconsider what kind of knowledge is generated therein through the preservation and display of factory-made artifacts, which give a sense of concreteness and gravitas to the industrial past. By studying the permanent exhibition and the collections of the Rosenlew Museum and by organizing a workshop with schoolchildren, I reveal the presence of various inertia effects. Long-term corporate values continue to influence the development of the museum’s permanent collection not only through the arrangement of industrial artifacts into a collection but also—at a heuristic level—through epistemological frames and the indexing power of the museum assemblage.
Collecting Medieval and Renaissance Manuscripts in Twentieth-Century Great Britain and North America
Authors: Burrows Toby
Published: February 2020

Medieval and Renaissance manuscripts were a significant commodity in the antiquarian sales market throughout the twentieth century, sought out by very wealthy collectors and small-scale buyers. The history of this manuscript market has not been analyzed systematically. This article is a first attempt to identify themes and trends across the century, beginning with the dominance of the great American Gilded Age collectors like Henry Huntington and the Morgans and their need to memorialize themselves. It argues that future research needs to assemble comprehensive data on prices and buyers in order to make possible more systematic analyses of trends and activities, and a more sophisticated understanding of the different reasons for which collectors collected and of the changing nature of manuscripts as objects with their own biographical trajectories and their own agency.
Field Notes and Reading Notes
Authors: Dias Nélia
Published: February 2020

In this article, I reflect on the experience of attending Barbara Kirshenblatt-Gimblett’s class Performance Studies Issues and Methods at New York University’s Tisch School of the Arts in the 1990s. Recalling the classes and field trips to events and sites in New York City, and the emphasis that she placed on reading texts and taking field notes, I consider the lessons I learned for performance studies, anthropology, and museums, and also for teaching, research, and scholarship in general. Why did this practice of taking notes from the field, from books in particular, and the note-taking practice in general, play such a central role in Kirshenblatt-Gimblett’s teaching? The steady and consistent focus both on theory and on the observation of social practices was a means of opening up new spaces for theoretical analysis or for a “performed theory,” to use Kirshenblatt-Gimblett’s term.
Exhibition Review Essay and Reviews
Authors: Stokes-Rees Emily , Moskowitz Blaire M. , Sun Moira , Wilson Jordan
Published: February 2020

Exhibition Review Essay:

Exhibition without Boundaries. teamLab Borderless and the Digital Evolution of Gallery Space
by Emily Stokes-Rees

Exhibition Reviews:

The Colmar Treasure: A Medieval Jewish Legacy. The Met Cloisters, The Metropolitan Museum of Art, New York
by Blaire M. Moskowitz

Shanghai Museum of Glass, Shanghai; Suzhou Museum, Suzhou; and PMQ, Hong Kong
by Moira Sun

The Story Box: Franz Boas, George Hunt and the Making of Anthropology. Exhibition at the Bard Graduate Center Gallery in New York City (14 February–7 July 2019) and the U’mista Cultural Centre in Alert Bay, British Columbia (20 July–24 October 2019)
by Jordan Wilson
PENGARUH PROFITABILITAS TERHADAP KEBIJAKAN DIVIDEN DENGAN ANALISA DATA PANEL PADA MULTI-BISNIS DI BURSA EFEK INDONESIA PERIODE 2007-2017
Authors: Purba Jan Horas Veryady
Published: February 2020

The issue of dividends is very important to show the prospects for the company's growth in the future, and also important in the company's capital structure. Dividend policy can be influenced by profitability and other variables. In this study, profitability is chosen due to its role as main indicator that shows the company's capacity to pay dividends.  This study aims to analyze the effect of profitability on dividend policy. The study population is a company listed on the Indonesia Stock Exchange. Purposively selected eight companies that have a good liquidity category. Data for each company is taken from 2007 to 2017. With this data structure, the analysis used is panel data regression analysis. Panel data analysis models include the Common Effect Model (CEM) Fixed Effect Model (FEM) and Random Effect Model (REM). The best model was tested with the Chow test and Hausman Test and obtained The Fixed Effect Model. Dividend policy is measured by the variable dividend payout ratio. The findings in this study conclude that the dividend policy (Dividend Payout Ratio) is influenced by ROE, EPS and NPM, where these independent variables have a positive and significant influence on DPR.
PENGARUH PROGRAM MOTIVASI KEWIRAUSAHAAN DALAM MEMBENTUK JIWA KEWIRAUSAHAAN IBU RUMAH TANGGA
Authors: Alhempi Raden Rudi , Anggraini Nia , Ulfah Mutia
Published: February 2020

This research was conducted in the city of Pekanbaru with the aim to determine the effect of entrepreneurial motivation to improve household welfare by empowering Housewives (IRT) as a productive workforce community. The majority of the residents of Limbungan Rumbai with the economic condition of middle-low class families, finding work is increasingly difficult, the need to meet daily needs is increasing. IRT in this region requires motivation in the form of knowledge and skills that can be used as provisions to start a business. The method of analyzing the data of this research is descriptive analysis, which is a research method that describes a situation and event on an actual problem and looks for facts with the correct interpretation as it is, and is not used as a broader conclusion maker. Based on the results of the study it was found that households need entrepreneurial motivation that can provide enlightenment of thought and understanding, especially to the IRT of the potential opportunities for family businesses so that growing interest and motivation in themselves to become entrepreneurs. IRT responds well to the large number of IRTs who ask questions related to problems starting a business and marketing. Keywords: Entrepreneur Motivation, Women's Empowerment, Womenpreneur
ANALISA KINERJA KEUANGAN BANK MUAMALAT INDONESIA DIBANDINGKAN DENGAN BANK BRI
Authors: Asraf Asraf
Published: February 2020

Perbankan syariah di Indonesia dinilai lambat berkembang. Setelah 28 tahun lebih sejak berdirinya bank syariah pertama di Indonesia yaitu Bank Muamalat Indonesia (BMI) yang diikuti sejumlah bank syariah lainnya, hanya mampu meraih pangsa pasar 5,94% saja. Pertumbuhan yang lamat ini ironis mengingat mayoritas penduduk Indonesia beragama Islam. Penelitian ini bermaksud untuk menganalisis kinerja keuangan bank BMI dan diperbandingkan dengan kinerja keuangan salah satu bank terbaik nasional versi Majallah Investor yaitu bank BRI. Analisis dilakukan terhadap ratio-ratio keuangan lima tahun terakhir yang dipublikasikan untuk kemudian diperbandingkan. Hasil penelitian menunjukkan bahwa bank BMI memiliki kelemahan terutama dari aspek kualitas aktiva produktif dan profitabilitas bila dibandingkan dengan bank BRI. Kelemahan pada kualitas aktiva produktif khususnya kredit (NPL) berdampak pada meningkatnya biaya operasional yang pada gilirannya kemampuan meraih laba juga akan rendah. Pertumbuhan assets berbasis profit generation (internal) menjadi sangat rendah. Hasil penelitian ini memberikan informasi bagi pengelola bank syariah di Indonesia bahwa untuk mengejar ketertinggalannya dan mampu berkembang memanfaatkan potensi pasar di Indonesia harus membenahi kualitas aktiva produktif terutama kualitas kredit, sedapat mungkin meningkatkan efisiensi pada biaya operasional memperlebar margin laba dan mengembangkan produk-produk fee based income.
Global existence and time decay estimate of solutions to the compressible Navier–Stokes–Korteweg system under critical condition
Authors: Kobayashi Takayuki , Tsuda Kazuyuki
Published: February 2020

In this research, we study the global existence of solutions to the compressible Navier–Stokes–Korteweg system around a constant state. This system describes liquid-vapor type two-phase flow with a phase transition with diffuse interface. Previous works assume that pressure is a monotone function for change of density similarly to the usual compressible Navier–Stokes system. On the other hand, due to phase transition the pressure is in fact non-monotone function, and the linearized system loses symmetry in a critical case such that the derivative of pressure is 0 at the given constant state. We show that global [Formula: see text] solutions are available for the critical case of small data, whose momentum is in its derivative form, and obtain parabolic type decay rate of the solutions. This is proved based on the decomposition of solutions to a low frequency part and a high frequency part.
Multiple eigenvalues for the Steklov problem in a domain with a small hole. A functional analytic approach
Authors: Lanza de Cristoforis Massimo
Published: February 2020

Let [Formula: see text]. Let [Formula: see text] be a bounded open domain of [Formula: see text] of class [Formula: see text]. Let [Formula: see text] denote the outward unit normal to [Formula: see text]. We assume that the Steklov problem [Formula: see text] in [Formula: see text], [Formula: see text] on [Formula: see text] has a multiple eigenvalue [Formula: see text] of multiplicity r. Then we consider an annular domain [Formula: see text] obtained by removing from [Formula: see text] a small cavity of class [Formula: see text] and size [Formula: see text], and we show that under appropriate assumptions each elementary symmetric function of r eigenvalues of the Steklov problem [Formula: see text] in [Formula: see text], [Formula: see text] on [Formula: see text] which converge to [Formula: see text] as ϵ tend to zero, equals real a analytic function defined in an open neighborhood of [Formula: see text] in [Formula: see text] and computed at the point [Formula: see text] for [Formula: see text] small enough. Here [Formula: see text] denotes the outward unit normal to [Formula: see text], and [Formula: see text] and [Formula: see text] if [Formula: see text]. Such a result is an extension to multiple eigenvalues of a previous result obtained for simple eigenvalues in collaboration with S. Gryshchuk.
Singular asymptotic expansion of the exact control for the perturbed wave equation
Authors: Castro Carlos , Münch Arnaud
Published: February 2020

The Petrowsky type equation [Formula: see text], [Formula: see text] encountered in linear beams theory is null controllable through Neumann boundary controls. Due to the boundary layer of size of order [Formula: see text] occurring at the extremities, these boundary controls get singular as ε goes to 0. Using the matched asymptotic method, we describe the boundary layer of the solution [Formula: see text] and derive a rigorous second order asymptotic expansion of the control of minimal weighted [Formula: see text]-norm, with respect to the parameter ε. The weight in the norm is chosen to guarantee the smoothness of the control. In particular, we recover and enrich earlier results due to J.-L. Lions in the eighties showing that the leading term of the expansion is a null Dirichlet control for the limit hyperbolic wave equation. The asymptotic analysis also provides a robust discrete approximation of the control for any ε small enough. Numerical experiments support our study.
The analysis of the levels of plasma inflammation-related cytokines and endotoxins in patients with acute aortic dissection
Authors: Liu Xiaojun , Wang Gang , Zhang Tao
Published: February 2020

OBJECTIVE: To investigate the changes in the levels of plasm interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), C-reactive protein (CRP), matrix metalloproteinase-9 (MMP-9) and endotoxins in patients with acute aortic dissection (AAD). METHODS: 55 AAD patients who were admitted and scheduled to undergo emergency surgery in our hospital from January 2017 to July 2017 were selected and retrospectively analyzed. They were divided into the survival group (n = 40) and the death group (n = 15). The levels of plasma IL-6, TNF-α, CRP, MMP-9 and endotoxins at admission and at 6 h, 12 h and 24 h after admission (T0, T1, T2 and T3) were measured, and the correlations of inflammatory cytokines with endotoxins were analyzed. RESULTS: At T1, T2 and T3, the levels of inflammatory cytokines and endotoxins were increased. The levels of plasma IL-6, TNF-α, CRP, MMP-9 and endotoxins in the death group were significantly higher than those in the survival group at each time point (p < 0.05 in all comparisons). Neutrophil and platelet counts in the death group were higher than those in the survival group (p < 0.05). Correlation analyses indicated that the levels of IL-6, TNF-α, CRP and MMP-9 were positively correlated with the level of endotoxin. CONCLUSION: Patients with AAD are often accompanied by systemic inflammatory responses, with inflammation-related cytokines (IL-6, TNF-α, CRP and MMP-9) and endotoxins levels significantly elevated. Combined monitoring of dynamic changes in inflammatory cytokines and endotoxins, as well as early interventions, has important clinical implications for evaluating the prognosis of AAD and reducing mortality.
Assessment of anti-cancer effects of koenimbine on colon cancer cells
Authors: Astaneh Maliheh , Ghafouri-Fard Soudeh , Fazeli Zahra , Taherian-Esfahani Zahra , Dashti Sepideh , Motevaseli Elahe
Published: February 2020

BACKGROUND: Recent studies have highlighted the role of natural elements in reduction of cancer cell growth and apoptosis. Koenimbine, a natural product isolated from Murraya koenigii (L) Spreng is a substance with cytotoxic effects on cancer cells. AIM: The effects of koenimbine on HT-29 and SW48 colon cancer cells were evaluated by MTT and Annexin V assays. Expression levels of Wnt/β-catenin pathway genes were quantified by real time PCR. RESULTS: The IC50 values of koenimbine in HT-29 and SW48 was calculated to be 50 μg/ml based on the results of MTT assay. This value was 75 μg/ml in IEC-18 cells which were used as normal control. Annexin V assays revealed induction of cell apoptosis and necrosis in HT-29 and SW48 cells but not IEG18 cells by koenimbine. Koenimbin treatment resulted in significant down-regulation of CYCLD1 expression in SW48 cell line, but up-regulation of this gene in HT29 cell line. Expression of TBLR1, DKK1, GSK3B and β-catenin was significantly decreased after koenimbin treatment in HT-19 cell line. Moreover, expression of DKK1 and GSK3B was significantly decreased after koenimbin treatment in SW-40 cell line. TCF4 expression was not detected in any of cell lines either before or after treatment with koenimbin. CONCLUSION: The current in vitro study showed the cytotoxic effects of koenimbin on two colon cancer cell lines and the effects of this substance on expression of selected genes from Wnt-β catenin pathway. Future in vivo studies are needed before suggestion of this substance as an anti-cancer drug.
Anthocyanin content, bioactive compounds and physico-chemical characteristics of potential new strawberry cultivars rich in-anthocyanins
Authors: Sirijan Mongkon , Pipattanawong Narongchai , Saeng-on Boonsong , Chaiprasart Peerasak
Published: February 2020

BACKGROUND: High anthocyanin content and the presence of other bioactive compounds are attractive characteristics of strawberry fruits for healthy consumption. OBJECTIVES: To characterize the anthocyanin content and the presence of other bioactive compounds, including anthocyanin (total and predominant types) andantioxidant activity; and to determine the physico-chemical fruit quality parameters of two new strawberry cultivars. METHOD: Fruits of two new hybrids were extracted and total anthocyanin and antioxidant activity were determined usinga UV-Vis spectrophotometer. Individual anthocyanins and vitamin C were measured using an HPLC. Physico-chemical characteristics of fruits were analyzed. RESULTS: Hybrid No. 4 line 5 and hybrid No. 4 line 26 are two potential new strawberry cultivars that are rich in anthocyanins. The total anthocyanin contents of these two hybrids were approximately 31–38 mg/100 g FW with no significant differences between them. Cyanidin 3-glucoside and pelargonidin 3-glucoside were foundat amounts of approximately 15–24 mg/kgFW and 332–478 mg/kg FW, respectively. Total phenolic compounds and FRAP activity of the two hybrids were approximately 2295–2579 mg GAE/kgFWand 27–30 mmol Fe2 +/kg FW, respectively. CONCLUSION: The two new hybrid strawberry lines, hybrid No. 4 line 5 and No. 4 line 26, when compared to the parents, had higher levels of bioactive compounds, especially anthocyanins, total phenolics, and FRAP, together with improved physico-chemical quality, and higher vitamin C content. These results indicate a considerable potential of these hybrids for commercial cultivation in Thailand and other production regions.
МОДЕЛЮВАННЯ ФУНКЦІОНУВАННЯ БЛОЧНИХ ЗАГОРОДЖУВАЛЬНИХ ПЕРЕШКОД ПІД ЧАС ПРИКРИТТЯ БЛОКПОСТІВ ТА КОНТРОЛЬНО-ПЕРЕПУСКНИХ ПУНКТІВ ВІД ВОГНЕВИХ ЗАСОБІВ ПРОТИВНИКА
Authors: Коцюруба Володимир , Кривцун Володимир
Published: February 2020

Забезпечення живучості важливих об’єктів, а саме мостів, шляхопроводів, базових районів, блокостів, контрольно-пропускних та контрольних пунктів в’їзду-виїзду та інших, досягається комплексним виконанням заходів з фортифікаційного обладнання та улаштування і утримання інженерних загороджень. Одним із оперативних та ефективних шляхів досягнення мети виконання цих заходів є застосування блочних загороджувальних перешкод із міцних матеріалів. Блочні загороджувальні перешкоди володіють захисними та загороджувальними властивостями і є альтернативним засобом у складних ґрунтових умовах та в умовах обмеження застосування мінно-вибухових загороджень. Розглянуто моделювання процесу впливу на блочну загороджувальну перешкоду вогневих засобів противника та спроможностей підрозділів, що обороняються та використовують її, щодо ураження вогневих засобів противника під час зустрічного вогневого впливу, а також відновлення боєздатного стану вогневих засобів противника після виходу з ладу. Наведено математичну модель щодо впливу вогневих засобів противника, переважно ударного типу, з метою зруйнування блочних загороджувальних перешкод із міцних матеріалів на блокпостах і контрольнопропускних пунктах, що займають підрозділи, які їх обороняють у районах ведення бойових дій. Математична модель, на відміну від існуючих, ураховує ймовірність виходу з ладу вогневих засобів противника внаслідок ураження під час зустрічного вогневого впливу підрозділами, що обороняються і використовують блочні загороджувальні перешкоди, та ймовірність відновлення боєздатного стану вогневих засобів противника. Запропонована математична модель ґрунтується на використанні напівмарковських процесів. Наведена в статті математична модель дозволяє дати відповіді на цілу низку питань відносно бойового функціонування системи, зокрема щодо часу перебуваня у відповідній множині станів, часу бойового функціонування вогневих засо-бів противника до моменту втрати ним боєздатного стану та блочної загороджувальної перешкоди до моменту її руйнування.
МЕТОДИКА ОПТИМІЗАЦІЇ ВИБОРУ ТЕХНІЧНИХ ЗАСОБІВ ОХОРОНИ ТА КОНТРОЛЮ СТАНУ ДЕРЖАВНОГО КОРДОНУ РЕСПУБЛІКИ КАЗАХСТАН
Authors: Мосов Сергій , Салій Сергій
Published: February 2020

У статті на системних засадах досліджено питання оптимізації вибору технічних засобів охорони та контролю стану державного кордону Республіки Казахстан. Наведена з використанням процесного підходу декомпозиція прикордонної діяльності з метою переходу до формування вимог до характеристик технічних засобів охорони та контролю стану державного кордону. Формалізовано тактико-технічні вимоги до таких технічних засобів: функціональне завдання, погодні умови, пора року, час доби, фізико-географічні характеристики місцевості, кліматичні умови, умови надзвичайних ситуацій, вплив природних та штучних перешкод з боку порушника державного кордону. До тактичних вимог включено типові завдання, елементи прикордонної тики, а також критерії оцінки ефективності застосування технічного засобу. Зазначено спільні для технічних засобів характеристики, які треба враховувати при виборі цих засобів: контролепридатність, ремонтопридатність, надійність, вартість технічного засобу і вартість його експлуатації. Визначено вигляд екстремуму, якому має відповідати технічний засіб з найкращими характеристиками. Звертається увага на важливість проведення патентних досліджень, від яких залежить проведення доопрацювань технічного засобу. На підставі апробованого експертного методу аналізу ієрархій запропоновано методику вирішення багатокритеріального завдання оптимізації вибору технічних засобів охорони та контролю стану державного кордону, яка дозволяє, по-перше, об’єктивно оцінювати наявні та перспективні технічні засоби, по-друге, необхідність забезпечення транзитивної узгодженості дозволяє фіксувати можливі спроби штучного завищення показників одного з технічних засобів (або оцінюваного), так як автоматично погіршаться показники іншого технічного засобу, і відношення узгодженості вийде з допустимих меж, тобто в цьому випадку зберігається принцип неупередженості та справедливості.
MELACAK MAKNA KONSEP KERUPAAN PADA LAMBANG INSTANSI DI INDONESIA DENGAN SUMBER BENTUK MATAHARI
Authors: Adisukma Wisnu
Published: February 2020

The article tittled Melacak Makna Konsep Kerupaan Pada Lambang Instansi di Indonesia dengan Sumber Bentuk Matahari is intended to pursue the textual and contextual meaning of institution sign with basic shape of sun. With iconographic approach would be obtained deeper and broader meaning from a work of art. Through this approach, the artwork will be a major concern in reviewing the history of art, nevertheless still necessary to understand the contextual and symbolic aspects. As the results, sign with basic shape of sun is the cosmic center, cental, foundation point, origin, sangkan paran, or axis mundi. Therefore, it is as the sun that is the problem solving of many problematics in its era.
A Fixed-Point Problem with Mixed-Type Contractive Condition
Authors: Vetro Calogero
Published: February 2020

We consider a fixed-point problem for mappings involving a mixed-type contractive condition in the setting of metric spaces. Precisely, we establish the existence and uniqueness of fixed point using the recent notions of $F$-contraction and $(H,\varphi)$-contraction.
ДУХОВНЕ І КУЛЬТУРНО-ПСИХОЛОГІЧНЕ В СУЧАСНОМУ ПЕДАГОГІЧНОМУ МИСЛЕННІ
Authors: Осадча Н. О.
Published: February 2020

У статті аналізуються питання, пов’язані із взаємодією духовних та культурно-психологічних чинників в сучасному педагогічному мисленні, що є актуальним для виховання учнівської молоді в епоху новітніх технологій. В минулому культурна психологія, як і культурно-історичні теорії, звертала увагу на «Я-концепцію» та соціальний характер особовості. Вчені ХХ ст. наблизилися до моральних основ розвитку дитини та зупинилися перед духовними чинниками, які мають непересічне значення для формування особовості.

В статті наголошується на тому, що поза полем соціально-психологічних досліджень ще залишаються питання, пов’язані з духовним розвитком дітей та підлітків. Не вивчався вплив духовного на процес інституціоналізації особовості. Не зверталася увага на те, що духовне, а не душевне формує внутрішній світ людини. Тому автор акцентує увагу на тому, що внутрішні духовні сили, поєднані з вірою, надією і любов’ю, роблять людину, в тому числі і підлітків, щирими, добрими і справедливими, такими, як цього вимагає етнокультурний спадок українського народу.

Батькам, як це зроблено в європейських країнах, має бути надане право вимагати від школи відповідного релігійного виховання своїх дітей; учні повинні мати можливість вибору між предметами духовного спрямування, які вивчаються в державних загальноосвітніх школах України. Церква разом із громадянським суспільством теж має нести відповідальність за духовне виховання та зміст навчання дітей і підготовку вчителів. Вони б мали спільними зусиллями виробити спільні програми формування світогляду дітей в умовах впливу на них новітніх технологій. В кожному конкретному випадку програми мають бути просякнуті загальноприйнятими духовними істинами і вибудовувати модель людини, яка буде жити й працювати в середині і кінці ХХІ ст.

Ключові слова: учнівська молодь, самотність, духовний розвиток підлітків, педагогічне мислення, культурна та культурно-історична психологія.
ДУХОВНІ ОРІЄНТИРИ РАДЯНСЬКОЇ ПЕДАГОГІКИ
Authors: Цибулько О. С.
Published: February 2020

У статті обґрунтована ідея наступності духовного розвитку особистості. Педагогічна думка сучасності не мала б підґрунтя для власного існування, якби молоде покоління, що незмінно оновлює суспільство, змінюючи попереднє, вимушене було б починати з чистого аркушу, без творчого засвоєння та розуміння того досвіду, яке напрацювало попереднє покоління. Питання духовності в педагогічних системах – це питання з категорії «вічних» питань. Але практична реалізація духовного змісту освіти, як і його наповнення, багато в чому залежить від соціокультурних, економічних та історичних чинників. Тобто кожний період розвитку людства має власне бачення ідеї духовного розвитку особистості. Отже, надзвичайної актуальності набуває дослідження духовно-виховних ідей радянської педагогіки як досвіду попередньої епохи.

Радянська педагогіка 30-90-х років XX століття демонструє закономірні зміни педагогічних орієнтирів, що послужили причиною формування в свідомості нових поколінь радянських громадян соціальної дезорієнтації. Церква в цей період не могла суттєво впливати на систему освіти, і державна влада вирішувала педагогічні проблеми, формуючи і надаючи освітній системі ідеалізованих образів: класиків марксизму-ленінізму, партії і її лідерів, земного раю, народу, історії людства. Ці образи дозволили народу не втратити повністю свій культурно-історичний тип, але в той же час, будучи помилковими, вони не могли сприяти духовному і моральному захисту, що в врешті-решт призвело до розпаду СРСР. Відтак, питання духовності як змісту педагогічної системи та виховання духовності, як основної педагогічної мети є стрижневими для будь-якого часу та суспільства.

Ключові слова: духовність, духовні цінності, радянська концепція духовності.
ФОРМУВАННЯ ПРОФЕСІЙНОГО ІМІДЖУ МАЙБУТНЬОГО ВЧИТЕЛЯ ТРУДОВОГО НАВЧАННЯ ТА ТЕХНОЛОГІЙ У ПОЗАНАВЧАЛЬНІЙ РОБОТІ ЗАКЛАДУ ВИЩОЇ ОСВІТИ
Authors: Бондаренко В. І.
Published: February 2020

У даному науковому дослідженні аналізується роль позанавчальної діяльності як фактору важливого впливу на формування професійного іміджу майбутнього вчителя трудового навчання та технологій. З’ясовано, що позанавчальна робота є об’єктом професійних компетенцій викладачів, найважливішою складовою «якості закладу вищої освіти». Визначено, що позанавчальна діяльність найбільш ефективно може бути організована під час системного характеру загально­університетських виховних заходів, які спрямовані на розвиток гуманістичних й інноваційних якостей особистості вчителя трудового навчання та технологій. Доведено, що у системі формування професійного іміджу майбутнього вчителя трудового навчання та технологій саме позанавчальна діяльність має переваги до формування у майбутніх учителів трудового навчання та технологій любові і поваги до обраної професії, бережливого ставлення до об’єктів своєї праці, культури професійної творчості та використання її продуктів у педагогічних цілях на заняттях й у позанавчальній діяльності, здатності до інновацій у змісті й організації уроків технології та виховної роботи, активність майбутнього вчителя трудового навчання та технологій у використанні інформаційно-комунікаційних технологій з метою підвищення власної професійної компетентності, здатність до самоформування професійного іміджу.

Презентується елемент програми формування педагогічного іміджу вчителя трудового навчання та технологій у позанавчальній діяльності. Розглядається специфічність використання групових та індивідуальних форм позанавчальної виховної діяльності в педагогічному університеті.

Ключові слова: професійний імідж, майбутній вчитель трудового навчання та технологій, позанавчальна діяльність, групові та індивідуальні форми виховної роботи.