Assessing Tumor-Infiltrating Lymphocytes in Solid Tumors: A Practical Review for Pathologists and Proposal for a Standardized Method from the International Immuno-Oncology Biomarkers Working Group: Part 2: TILs in Melanoma, Gastrointestinal Tract Carcinomas, Non–Small Cell Lung Carcinoma and Mesothelioma, Endometrial and Ovarian Carcinomas, Squamous Cell Carcinoma of the Head and Neck, Genitourinary Carcinomas, and Primary Brain Tumors
Authors: Hendry Shona , Salgado Roberto , Gevaert Thomas , Russell Prudence A. , John Tom , Thapa Bibhusal , Christie Michael , van de Vijver Koen , Estrada M.V. , Gonzalez-Ericsson Paula I. , Sanders Melinda , Solomon Benjamin , Solinas Cinzia , Van den Eynden Gert G.G.M. , Allory Yves , Preusser Matthias , Hainfellner Johannes , Pruneri Giancarlo , Vingiani Andrea , Demaria Sandra , Symmans Fraser , Nuciforo Paolo , Comerma Laura , Thompson E.A. , Lakhani Sunil , Kim Seong-Rim , Schnitt Stuart , Colpaert Cecile , Sotiriou Christos , Scherer Stefan J. , Ignatiadis Michail , Badve Sunil , Pierce Robert H. , Viale Giuseppe , Sirtaine Nicolas , Penault-Llorca Frederique , Sugie Tomohagu , Fineberg Susan , Paik Soonmyung , Srinivasan Ashok , Richardson Andrea , Wang Yihong , Chmielik Ewa , Brock Jane , Johnson Douglas B. , Balko Justin , Wienert Stephan , Bossuyt Veerle , Michiels Stefan , Ternes Nils , Burchardi Nicole , Luen Stephen J. , Savas Peter , Klauschen Frederick , Watson Peter H. , Nelson Brad H. , Criscitiello Carmen , O’Toole Sandra , Larsimont Denis , de Wind Roland , Curigliano Giuseppe , André Fabrice , Lacroix-Triki Magali , van de Vijver Mark , Rojo Federico , Floris Giuseppe , Bedri Shahinaz , Sparano Joseph , Rimm David , Nielsen Torsten , Kos Zuzana , Hewitt Stephen , Singh Baljit , Farshid Gelareh , Loibl Sibylle , Allison Kimberly H. , Tung Nadine , Adams Sylvia , Willard-Gallo Karen , Horlings Hugo M. , Gandhi Leena , Moreira Andre , Hirsch Fred , Dieci Maria V. , Urbanowicz Maria , Brcic Iva , Korski Konstanty , Gaire Fabien , Koeppen Hartmut , Lo Amy , Giltnane Jennifer , Rebelatto Marlon C. , Steele Keith E. , Zha Jiping , Emancipator Kenneth , Juco Jonathan W. , Denkert Carsten , Reis-Filho Jorge , Loi Sherene , Fox Stephen B. 
Published: August 2017

Assessment of the immune response to tumors is growing in importance as the prognostic implications of this response are increasingly recognized, and as immunotherapies are evaluated and implemented in different tumor types. However, many different approaches can be used to assess and describe the immune response, which limits efforts at implementation as a routine clinical biomarker. In part 1 of this review, we have proposed a standardized methodology to assess tumor-infiltrating lymphocytes (TILs) in solid tumors, based on the International Immuno-Oncology Biomarkers Working Group guidelines for invasive breast carcinoma. In part 2 of this review, we discuss the available evidence for the prognostic and predictive value of TILs in common solid tumors, including carcinomas of the lung, gastrointestinal tract, genitourinary system, gynecologic system, and head and neck, as well as primary brain tumors, mesothelioma and melanoma. The particularities and different emphases in TIL assessment in different tumor types are discussed. The standardized methodology we propose can be adapted to different tumor types and may be used as a standard against which other approaches can be compared. Standardization of TIL assessment will help clinicians, researchers and pathologists to conclusively evaluate the utility of this simple biomarker in the current era of immunotherapy.