bluuebunny/crossref_metadata_2025 huggingface dataset:
Learning Kernel Stein Discrepancy for Training Energy-Based Models
Authors: Niu Lu , Li Shaobo , Li Zhenping
Published: November 2023

The primary challenge in unsupervised learning is training unnormalized density models and then generating similar samples. Few traditional unnormalized models know what the quality of the trained model is, as most models are evaluated by downstream tasks and often involve complex sampling processes. Kernel Stein Discrepancy (KSD), a goodness-of-fit test method, can measure the discrepancy between the generated samples and the theoretical distribution; therefore, it can be employed to measure the quality of trained models. We first demonstrate that, under certain constraints, KSD is equal to Maximum Mean Discrepancy (MMD), a two-sample test method. PT KSD GAN (Kernel Stein Discrepancy Generative Adversarial Network with a Pulling-Away Term) is produced to compel generated samples to approximate the theoretical distribution. The generator, functioning as an implicit generative model, employs KSD as loss to avoid tedious sampling processes. In contrast, the discriminator is trained to identify the data manifold, also known as an explicit energy-based model. To demonstrate the effectiveness of our approach, we undertook experiments on two-dimensional toy datasets. Our results highlight that our generator adeptly captures the accurate density distribution, while the discriminator proficiently recognizes the unnormalized approximate distribution shape. When applied to linear Independent Component Analysis datasets, the log likelihoods of PT KSD GAN improve by about 5‰ over existing methods when the data dimension is less than 30. Furthermore, our tests on image datasets reveal that the PT KSD GAN excels in navigating high-dimensional challenges, yielding authentically genuine samples.
WebAR as a Mediation Tool Focused on Reading and Understanding of Technical Drawings Regarding Tailor-Made Projects for the Scenographic Industry
Authors: Lôbo José Eduardo Araújo , Correia Walter Franklin Marques , Teixeira João Marcelo , Siqueira José Edeson de Melo , Roberto Rafael Alves
Published: November 2023

Among the leading immersive technologies, augmented reality is one of the most promising and empowering for supporting designers in production environments. This research investigates the application of mobile augmented reality, based on the Web, as a mediation tool focused on cognitive activities of reading and understanding of technical drawings in the production and assembly of tailor-made projects of the scenographic industry. In this context, the research presents a method to use WebAR to improve the reading of technical drawings, seeking efficiency in the visualization of models and the exchange of information between professionals involved in the processes of design, production, and assembly of products, in the scope of scenography. This mediation tool was developed using Web AR platforms, compatible with native libraries (ARCore and ARKit) to ensure, first, compatibility with commonly used devices that workers or businesses can access, and second, to leverage hybrid tracking techniques that combine vision and sensors to improve the reliability of augmented reality viewing. The proposed solution adopts multiple tracking and navigation techniques in order to expand Space Skills components to provide greater exploratory freedom to users. The research process took place in light of the Design Science Research Methodology and the DSR-Model, since it aimed to develop a solution to a practical problem, as well as to produce knowledge from this process. Field experiments were conducted in two real companies, with end users on their respective mobile devices, in order to evaluate usability and behavioral intent, through the Acceptance, Intent, and Use of Technology questionnaires and perceived mental workload, NASA-TLX. The experimental results show that the adoption of this tool reduces the cognitive load in the process of reading technical drawings and project understanding. In general, its usability and intent to use provided significant levels of satisfaction, being positively accepted by all participants involved in the study.
Solid Backfilling Efficiency Optimization in Coal Mining: Spatiotemporal Linkage Analysis and Case Study
Authors: Zong Tingcheng , Zhu Gaolei , Zhang Qiang , Yang Kang , Wang Yunbo , Han Yu , Lv Haonan , Cao Jinming
Published: November 2023

In coal mining, solid backfilling technology is widely used. However, its efficiency is seriously hindered by the following two factors. Firstly, the process flow of the solid backfilling operation is more complicated in the back, and the spatiotemporal linkage (SPL) between actions of the cylinders powering each support and between hydraulic supports in the whole face lacks continuity. Secondly, the coal mining process in the front has a higher level of intelligence and technical maturity than the backfilling operation in the back, the latter permanently staying behind the former. To this end, the present study investigates the SPL of the mining and backfilling operations for single supports in the working and whole faces. The SPL of cylinder actions is analyzed for intelligent backfilling using hydraulic supports. We also investigate the SPL of the positions of each piece of key equipment involved in different steps of intelligent backfilling in the whole face. Formulas are derived for calculating the time required to complete the cyclic hydraulic support movement–discharge–filling operation for single supports and the whole face. The key factors influencing the time required to complete a hydraulic support movement–discharge–filling cycle are analyzed. On this basis, a backfilling efficiency optimization scheme is proposed. It envisages reducing the number of tampings and time gaps in actions of single supports and cylinders, increasing the number of hydraulic supports in parallel operation, and intelligent upgrading of the backfilling operation. These findings help synchronize coal mining and backfilling operations.
A Study of Reciprocal Job Recommendation for College Graduates Integrating Semantic Keyword Matching and Social Networking
Authors: Yao Jinping , Xu Yunhong , Gao Jiaojiao
Published: November 2023

With the surge in college graduate numbers, a disparity has emerged where the supply of jobs falls short of demand, intensifying employment pressures annually. College graduates, due to their lack of historical employment data compared with job seekers in the broader society, encounter a ‘cold start’ issue in the job recommendation process. Additionally, the nature of job recommendations, which differs fundamentally from unilateral recommendations, requires consideration of reciprocity between both parties involved. This article introduces a new approach to job recommendations using college graduates as the object of study. In the screening stage, a semantic keyword iterative algorithm is applied to compute the similarity between the resume and recruitment texts. This algorithm enhances the intersectionality of keywords in the calculation process, maximizing the utilization of resume information to enhance the accuracy of text similarity calculations. The ranking phase utilizes in-school data to build a social network between college graduates and graduated students and solves the system’s cold-start problem using the social network to recommend jobs for college graduates where graduated students are employed. We introduce a dual-dimensional matching approach that incorporates both specialty and salary, building upon the amalgamated semantic keyword iterative algorithm and the social network job recommendation method, to enhance the reciprocity of job recommendations. The job recommendation method introduced herein outperforms other methods in terms of the average satisfaction rate (AR) and normalized discounted cumulative gain (NDCG), thereby confirming its superior ability to meet the job-seeking preferences of graduates and the recruitment criteria of employers. This job recommendation method offers effective assistance to graduates lacking employment experience and historical employment data, facilitating their search for more suitable job opportunities.
Biomechanical Study of the Eye with Keratoconus-Type Corneal Ectasia Using a 3D Geometric Model
Authors: Sánchez-Real Emily , Otuna-Hernández Diego , Fajardo-Cabrera Alisson , Davies-Alcívar Rosemary , Madrid-Pérez Mario , Cadena-Morejón Carolina , Almeida-Galárraga Diego , Guevara Cesar , Tirado-Espín Andrés , Villalba-Meneses Fernando
Published: November 2023

Keratoconus is an eye disease that distorts the shape of the cornea. This study aimed to analyze the effect of an increase in intraocular pressure applied to eyes with different severity of keratoconus disease using patient-specific models. Finite element models of the normal eye, eye with keratoconus, and eye with keratoglobus were constructed. The loading conditions considered the intraocular pressure increment as well as their physiological intraocular pressure. The analysis was performed with distinct materials for normal and keratoconic eyes. The finite element analysis revealed differences in the three models in terms of their deformation and maximum principal stress, and differences were observed in corneal curvature and thickness. These findings could enhance research in the biomechanical area, leading to more successful treatment options and a more individualized approach in the field of practical ophthalmology. Further investigation with larger sample sizes and more precise data on eye material would allow us to evaluate whether these disparities could inform the diagnosis of keratoconus.
Research on Panorama Generation from a Multi-Camera System by Object-Distance Estimation
Authors: Cui Hongxia , Zhao Ziwei , Zhang Fangfei
Published: November 2023

Panoramic imagery from multi-camera systems often suffers the problem of geometric mosaicking errors due to eccentric errors between the optical centers of cameras and variations in object-distances within the panoramic environment. In this paper, an inverse rigorous panoramic imaging model was derived completely for a panoramic multi-camera system. Additionally, we present an estimation scheme aimed at extracting object-distance information to enhance the seamlessness of panoramic image stitching. The essence of the scheme centers around our proposed object-space-based image matching algorithm called the Panoramic Vertical Line Locus (PVLL). As a result, panoramas were generated using the proposed inverse multi-cylinder projection method, utilizing the estimated object-distance information. The experiments conducted on our developed multi-camera system demonstrate that the root mean square errors (RMSEs) in the overlapping areas of panoramic images are no more than 1.0 pixel. In contrast, the RMSEs of the conventional traditional methods are typically more than 6 pixels, and in some cases, even exceed 30 pixels. Moreover, the inverse imaging model has successfully addressed the issue of empty pixels. The proposed method can effectively meet the accurate panoramic imaging requirements for complex surroundings with varied object-distance information.
Current Concepts about Calcaneal Fracture Management: A Review of Metanalysis and Systematic Reviews
Authors: Leigheb Massimiliano , Codori Francesco , Samaila Elena Manuela , Mazzotti Antonio , Villafañe Jorge Hugo , Bosetti Michela , Ceccarini Paolo , Cochis Andrea , Daou Farah , Ronga Mario , Grassi Federico Alberto , Rimondini Lia
Published: November 2023

Background: The fracture of the calcaneus is the most common traumatic lesion of the hindfoot and can cause severe disability with social and economic sequelae. Since 1980, an increasing number of studies and new technologies have led to an improvement in the management of calcaneal fractures, but treatment is still controversial. The purpose of this review was to investigate the secondary scientific literature to detect the optimal management of calcaneal fracture. Methods: A MEDLINE search via PubMed was conducted. A total of 4856 articles were identified, and only meta-analyses and systematic reviews were included. Results: 59 articles with more than 10,000 calcaneus fractures were examined, and the results were divided into various topics. Most articles agree on the superiority of surgical treatments compared to conservative ones. Moreover, minimally invasive access to the sinus tarsi showed better results and fewer complications than traditional extended lateral access. Also, reduction and osteosynthesis with percutaneous and/or minimally invasive techniques seem to provide better outcomes when compared to open treatments. Conclusions: The management of calcaneal fractures requires an individualized treatment plan based on the functional demands of the patient, the type of fracture, and associated injuries. New technologies and further studies can lead to an improvement in the management of calcaneal fractures.
Special Issue on Biochemical Composition of Food
Authors: Viskelis Pranas , Viskelis Jonas , Urbonaviciene Dalia
Published: November 2023

Food biochemistry concepts and principles have recently become essential in all main areas of food science, including food engineering, processing, technology, and safety [...]
Effect of Single and Double Moment Microphysics Schemes and Change in Cloud Condensation Nuclei, Latent Heating Rate Structure Associated with Severe Convective System over Korean Peninsula
Authors: Madhulatha A. , Dudhia Jimy , Park Rae-Seol , Bhan Subhash Chander , Mohapatra Mrutyunjay
Published: November 2023

To investigate the impact of advanced microphysics schemes using single and double moment (WSM6/WDM6) schemes, numerical simulations are conducted using Weather Research and Forecasting (WRF) model for a severe mesoscale convective system (MCS) formed over the Korean Peninsula. Spatial rainfall distribution and pattern correlation linked with the convective system are improved in the WDM6 simulation. During the developing stage of the system, the distribution of total hydrometeors is larger in WDM6 compared to WSM6. Along with the mixing ratio of hydrometeors (cloud, rain, graupel, snow, and ice), the number concentration of cloud and rainwater are also predictable in WDM6. To understand the differences in the vertical representation of cloud hydrometeors between the schemes, rain number concentration (Nr) from WSM6 is also computed using particle density to compare with the Nr readily available in WDM6. Varied vertical distribution and large differences in rain number concentration and rain particle mass is evident between the schemes. Inclusion of the number concentration of rain and cloud, CCN, along with the mixing ratio of different hydrometers has improved the storm morphology in WDM6. Furthermore, the latent heating (LH) profiles of six major phase transformation processes (condensation, evaporation, freezing, melting, deposition, and sublimation) are also computed from microphysical production terms to deeply study the storm vertical structure. The main differences in condensation and evaporation terms are evident between the simulations due to the varied treatment of warm rain processes and the inclusion of CCN activation in WDM6. To investigate cloud–aerosol interactions, numerical simulation is conducted by increasing the CCN (aerosol) concentration in WDM6, which simulated comparatively improved pattern correlation for rainfall simulation along with intense hydrometer distribution. It can be inferred that the change in aerosol increased the LH of evaporation and freezing and affected the warming and cooling processes, cloud vertical distribution, and subsequent rainfall. Relatively, the WDM6 simulated latent heating profile distribution is more consistent with the ERA5 computed moisture source and sink terms due to the improved formulation of warm rain processes.
Doppler LiDAR Observation of Subsidence in Synoptic Scale and Performance of a Global Numerical Weather Prediction Model in Capturing the Subsidence
Authors: Chan Pak-Wai , Yim Steve Hung-Lam , Huang Tao
Published: November 2023

The vertical velocity data from a Doppler LiDAR situated at the centre of Hong Kong were examined to look for signature of subsidence within the atmospheric boundary layer against a synoptic background. Two case studies were performed, namely, stable atmospheric conditions in foggy weather and possible “subsidence heating” at the periphery of the outer circulation of an intense tropical cyclone. The LiDAR’s Doppler velocity data were found to provide insights into the vertical motion of the air on the synoptic scale. They appear to confirm subsidence in foggy weather but provide new information about the mechanism for the occurrence of extremely hot weather. The data were also compared with vertical velocity forecasts from a numerical weather prediction model to assess the quality of the forecast. The Doppler LiDAR’s vertical velocity data were found to be useful in the verification of omega forecasts from the global numerical weather prediction model. They were found to provide further insights into the subsidence of the troposphere, particularly the atmospheric boundary layer, in certain synoptic patterns.
Preparation and Characterization of Mono- and Biphasic Ca1−xAgxHPO4·nH2O Compounds for Biomedical Applications
Authors: Abdulaziz Fahad , Issa Khalil , Alyami Mohammed , Alotibi Satam , Alanazi Abdulaziz A. , Taha Taha Abdel Mohaymen , Saad Asma M. E. , Hammouda Gehan A. , Hamad Nagat , Alshaaer Mazen
Published: November 2023

This study aimed to explore the effects of the full-scale replacement (up to 100%) of Ca2+ ions with Ag1+ ions in the structure of brushite (CaHPO4·2H2O). This substitution has potential benefits for producing monophasic and biphasic Ca1−xAgxHPO4·nH2O compounds. To prepare the starting solutions, (NH4)2HPO4, Ca(NO3)2·4H2O, and AgNO3 at different concentrations were used. The results showed that when the Ag/Ca molar ratio was below 0.25, partial substitution of Ca with Ag reduced the size of the unit cell of brushite. As the Ag/Ca molar ratio increased to 4, a compound with both monoclinic CaHPO4·2H2O and cubic nanostructured Ag3PO4 phases formed. There was a nearly linear relationship between the Ag ion ratio in the starting solutions and the wt% precipitation of the Ag3PO4 phase in the resulting compound. Moreover, when the Ag/Ca molar ratio exceeded 4, a single-phase Ag3PO4 compound formed. Hence, adjusting the Ag/Ca ratio in the starting solution allows the production of biomaterials with customized properties. In summary, this study introduces a novel synthesis method for the mono- and biphasic Ca1−xAgxHPO4·nH2O compounds brushite and silver phosphate. The preparation of these phases in a one-pot synthesis with controlled phase composition resulted in the enhancement of existing bone cement formulations by allowing better mixing of the starting ingredients.
Role of Vagus Nerve Stimulation in Refractory and Super Refractory Status Epilepticus: A Pediatric Case Series
Authors: Furlanis Giulia Melinda , Favaro Jacopo , Bresolin Nicola , Grioni Daniele , Baro Valentina , D’Amico Alberto , Sartori Stefano , Denaro Luca , Landi Andrea
Published: November 2023

Background: Status epilepticus is a life-threatening condition that is defined as refractory (RSE) when the seizure activity continues despite treatment with benzodiazepine and a second appropriate treatment. Super refractory status epilepticus (SRSE) is an RSE that persists or recurs for ≥24 h. Few papers have reported the outcomes of pediatric patients affected by RSE and SRSE and treated with neuromodulation therapies. Vagus nerve stimulation (VNS) is an approved treatment for drug-resistant epilepsy. We present our findings of pediatric patients treated with VNS for RSE/SRSE. Methods: We present a case series of seven consecutive pediatric patients treated with VNS for SRSE since 2012 by a single surgeon in Monza and Padua. A rapid titration was started soon after implantation. We considered electroclinical data before and after VNS implantation and at the last follow-up. Results: We achieved the resolution of SRSE in five out of seven patients in a mean time of two weeks. At the last follow-up, these patients had a significant reduction of seizure burden without any relapse of SE. Discussion and Conclusions: Based on our limited findings, we discuss the potential role of VNS therapy in similar but distinct clinical contexts. For patients with drug-resistant epilepsy and RSE/SRSE, prompt VNS consideration is suggested, offering rapid responses and potentially reducing pharmacological load. Meanwhile, in NORSE/FIRES, we suggest early neuromodulation during the acute phase if standard treatments prove ineffective or not tolerated. This approach may leverage VNS’s potential anti-inflammatory effects and neuromodulation, enhancing patient-specific treatments. Expanding case studies and prolonged follow-ups are recommended to strengthen these clinical insights.
Test and Numerical Simulation of the Axial Compressive Capacity of Concrete Columns Reinforced by Duplex Stainless Steel Bars
Authors: Ren Zhenhua , Wang Hui , Fang Lizheng , Ding Peng , Zeng Xiantao
Published: November 2023

Stainless steel has the characteristics of oxidation resistance, high temperature resistance, corrosion resistance, high strength, and high yield ratio. The use of stainless steel bars can extend the life of a structure, reduce later maintenance costs, and reduce the whole life cycle cost of the structure. In this paper, nine concrete columns reinforced with duplex stainless steel (S2205) (DSSRC) and nine ordinary reinforced concrete columns (ORC) were poured with the diameter of steel bars as the parameter, and axial compression tests were carried out on these eighteen concrete columns. The failure mode of the concrete columns is analyzed, and the compressive performance indexes of the two kinds of concrete columns are compared. The results show that, compared with the ORC, the cracking load of DSSRC is increased by 33%, the ultimate load is increased by 30.7%, and the deformation performance of the DSSRC is also improved significantly. On the basis of the test, the finite element model of DSSRC was established with the help of ABAQUS software, and the obtained failure law was consistent with the test; the experimental value, the calculated value, and the numerical simulation value of the axial compression capacity were in good agreement, which verified the feasibility of the test and provided a theoretical basis for practical engineering applications.
A Study of the Mechanical Properties of Polyester Fiber Concrete Continuous Rigid Frame Bridge during Construction
Authors: Miao Shouju , Zhan Xiaojian , Yuan Yangbing , Jia Lijun
Published: November 2023

This study investigates the mechanical performance of a polyester fiber concrete continuous rigid frame bridge during construction and the spatial stress distribution of the 0# block box girder, with a focus on the backdrop of the bridge in Pipa Zhou, Jiangxi Province. Stress monitoring at critical cross-sections during bridge construction was combined with FE simulations to analyze the stress and alignment deviation variations along the cantilevered construction process of the bridges. Subsequently, after validating the accuracy of the whole bridge model, the actual internal force of the box girder cross-section was extracted to act on the 0# block box girder solid model, and the spatial force of the 0# block box girder under the state of maximal cantilever and the completed bridge was further investigated. The results indicate that during cantilever construction, the top, and bottom plates of the box girder were subjected to compression, with the bottom plates having relatively low compression stress close to the critical values for compression and tension. Attention should be paid to controlling tensile stress application. After reaching a quarter of the bridge’s span in construction, the alignment deviation of the main beam increases, necessitating enhanced monitoring and adjustments of the main beam elevation. Furthermore, FE analysis shows that under maximum cantilever and the completed bridge states, the stress variations of the top and bottom plates of the 0# block box girder remain consistent, with the top plate stress varying by no more than 2.5 MPa and the bottom plate stress varying by approximately 1 MPa. Moreover, the 0# block box girder shrinkage cracks were mainly located in the bottom and web plate, and the number of cracks in the 0# block box girder with polyester fibers was reduced compared to the cracks in the ordinary concrete box girder.
A Review of Carbon Nanotubes, Graphene and Nanodiamond Based Strain Sensor in Harsh Environments
Authors: Wang Xiaoyan , Lim Eng Gee , Hoettges Kai , Song Pengfei
Published: November 2023

Flexible and wearable electronics have attracted significant attention for their potential applications in wearable human health monitoring, care systems, and various industrial sectors. The exploration of wearable strain sensors in diverse application scenarios is a global issue, shaping the future of our intelligent community. However, current state-of-the-art strain sensors still encounter challenges, such as susceptibility to interference under humid conditions and vulnerability to chemical and mechanical fragility. Carbon materials offer a promising solution due to their unique advantages, including excellent electrical conductivity, intrinsic and structural flexibility, lightweight nature, high chemical and thermal stability, ease of chemical functionalization, and potential for mass production. Carbon-based materials, such as carbon nanotubes, graphene, and nanodiamond, have been introduced as strain sensors with mechanical and chemical robustness, as well as water repellency functionality. This review reviewed the ability of carbon nanotubes-, graphene-, and nanodiamond-based strain sensors to withstand extreme conditions, their sensitivity, durability, response time, and diverse applications, including strain/pressure sensors, temperature/humidity sensors, and power devices. The discussion highlights the promising features and potential advantages offered by these carbon materials in strain sensing applications. Additionally, this review outlines the existing challenges in the field and identifies future opportunities for further advancement and innovation.
Updates on Breast Cancer
Authors: Pesapane Filippo , Nicosia Luca , Cassano Enrico
Published: November 2023

This collection of 18 articles, comprising 12 original studies, 1 systematic review, and 5 reviews, is a collaborative effort by distinguished experts in breast cancer research, and it has been edited by Dr [...]
Exploring Therapeutic Avenues in Lung Cancer: The Epigenetic Perspective
Authors: Munteanu Raluca , Tomuleasa Ciprian , Iuga Cristina-Adela , Gulei Diana , Ciuleanu Tudor Eliade
Published: November 2023

Lung cancer, primarily non-small cell lung carcinoma (NSCLC) and small cell lung carcinoma (SCLC), is distinguished by its high prevalence and marked mortality rates. Traditional therapeutic approaches, encompassing chemotherapy, radiation, and targeted therapies, frequently show limited efficacy due to acquired resistance and notable side effects. The objective of this review is to introduce a fresh perspective on the therapeutic strategies for lung cancer, emphasizing interventions targeting the epigenetic alterations often seen in this malignancy. This review presents the most recent advancements in the field, focusing on both past and current clinical trials related to the modulation of methylation patterns using diverse molecular agents. Furthermore, an in-depth analysis of the challenges and advantages of these methylation-modifying drugs will be provided, assessing their efficacy as individual treatments and their potential for synergy when integrated with prevailing therapeutic regimens.
Detection of Liver Lesions in Colorectal Cancer Patients Using 18F-FDG PET/CT Dual-Time-Point Scan Imaging
Authors: Boanova Luciane G. , Altmayer Stephan , Watte Guilherme , Raupp Ana Amelia , Francisco Martina Zaguini , De Oliveira Guilherme Strieder , Hochhegger Bruno , Andrade Rubens G. F.
Published: November 2023

Objective: The aim of this study was to evaluate the diagnostic performance of dual-time-point fluorine-18-fluorodeoxyglucose positron emission computed tomography/computed tomography (18F-FDG PET/CT) compared to conventional early imaging for detecting colorectal liver metastases (CRLM) in colorectal cancer (CRC) patients. Methods: One hundred twenty-four consecutive CRC patients underwent dual-time-point imaging scans on a retrospective basis. Histopathological confirmation and/or clinical follow-up were accepted as the gold standard. Standard uptake values (SUV), signal-to-noise ratio (SNR), retention index (RI), tumor-to-normal liver ratio (TNR), and lesion sizes were measured for early and delayed PET scans. The diagnostic performance of early and delayed images was calculated on a per-patient basis and compared using McNemar’s test. Results: Among the 124 patients, 57 (46%) had CRLM, 6 (4.8%) had benign lesions, and 61 (49.2%) had no concerning lesions detected. Smaller CRLM lesions (<5 cm3) showed significantly higher uptake in the delayed scans relative to early imaging (p < 0.001). The SUV and TNR increased significantly in delayed imaging of all metastatic lesions (p < 0.001). The retention index of all CRLM was high (40.8%), especially for small lesions (54.8%). A total of 177 lesions in delayed images and 124 in standard early images were identified. In a per-patient analysis, delayed imaging had significantly higher sensitivity (100% vs. 87.7%) and specificity (91.0% vs. 94.0%) compared to early imaging (p-value = 0.04). Conclusions: The detection of liver lesions using dual-time-point PET/CT scan improves the sensitivity and specificity for the detection of colorectal liver metastasis.
Oleic Acid Exhibits Anti-Proliferative and Anti-Invasive Activities via the PTEN/AKT/mTOR Pathway in Endometrial Cancer
Authors: Deng Boer , Kong Weimin , Suo Hongyan , Shen Xiaochang , Newton Meredith A. , Burkett Wesley C. , Zhao Ziyi , John Catherine , Sun Wenchuan , Zhang Xin , Fan Yali , Hao Tianran , Zhou Chunxiao , Bae-Jump Victoria L.
Published: November 2023

Reprogramming of fatty acid metabolism promotes cell growth and metastasis through a variety of processes that stimulate signaling molecules, energy storage, and membrane biosynthesis in endometrial cancer. Oleic acid is one of the most important monounsaturated fatty acids in the human body, which appears to have both pro- and anti-tumorigenic activities in various pre-clinical models. In this study, we evaluated the potential anti-tumor effects of oleic acid in endometrial cancer cells and the LKB1fl/flp53fl/fl mouse model of endometrial cancer. Oleic acid increased lipogenesis, inhibited cell proliferation, caused cell cycle G1 arrest, induced cellular stress and apoptosis, and suppressed invasion in endometrial cancer cells. Targeting of diacylglycerol acyltransferases 1 and 2 effectively increased the cytotoxicity of oleic acid. Moreover, oleic acid significantly increased the expression of wild-type PTEN, and knockdown of PTEN by shRNA partially reversed the anti-proliferative and anti-invasive effects of oleic acid. Inhibition of the AKT/mTOR pathway by ipatasertib effectively increased the anti-tumor activity of oleic acid in endometrial cancer cells. Oleic acid treatment (10 mg/kg, daily, oral) for four weeks significantly inhibited tumor growth by 52.1% in the LKB1fl/flp53fl/fl mice. Our findings demonstrated that oleic acid exhibited anti-tumorigenic activities, dependent on the PTEN/AKT/mTOR signaling pathway, in endometrial cancer.
Bilaterality as a Risk Factor for Recurrence in Papillary Thyroid Carcinoma
Authors: Kim Hyeji , Kwon Hyungju
Published: November 2023

Previous studies suggested that the multifocality of papillary thyroid carcinoma (PTC) would increase the risk of recurrence; however, the impact of its bilaterality remains unclear. Between 2011 and 2018, 1258 patients with PTC underwent total thyroidectomy at Ewha University Medical Center. The 5-year recurrence-free survival rate was 95.7% in patients with bilateral PTC, while those with unilateral multifocal PTC and a unifocal tumor showed a 5-year event-free survival rate of 97.0% and 97.8%, respectively (p = 0.004). A multivariable Cox proportional hazards model indicated that bilaterality (HR 2.550, 95% CI 1.354–4.800), male sex (HR 2.010, 95% CI 1.007–4.013), and tumor size (HR 1.748, 95% CI 1.316–2.323) were associated with recurrence, although unilateral multifocality did not increase the risk of recurrence (HR 1.211, 95% CI 0.348–4.213). In conclusion, bilaterality was associated with aggressive features, including tumor size and microscopic ETE. Moreover, bilaterality was an independent predictor of recurrence in patients with PTC. Patients with bilateral PTC might require careful treatment and follow-up approaches.
Structure and Catalytic Performance of Carbon-Based Solid Acids from Biomass Activated by ZnCl2
Authors: Wu Yao , Zhang Hao , Wei Zhaozhou , Xiong Deyuan , Bai Songbai , Tong Menglong , Ma Pengcheng
Published: November 2023

In the current investigation, carbon-based solid acid catalysts were synthesized from peanut shells (PSs) and rice straw (RS) using ZnCl2 activation and concentrated sulfuric acid sulfonation. These catalysts were then employed for the hydration of pinene to produce terpineol. The research findings suggest that the natural porous structure of RS is more amenable to ZnCl2 activation compared to PSs. Furthermore, the catalysts prepared from fully activated RS by ZnCl2 (RSA-C-S) had a higher SBET and higher density of oxygen-containing groups (–COOH) in comparison with unactivated RS-based solid acids (RSC-S). The characterization outcomes revealed that RSA-C-S possesses a specific surface area of 527.0 m2/g, significantly outperforming RSC-S, which has a surface area of 420.9 m2/g. Additionally, RSA-C-S registered a higher –COOH density of 1.37 mmol/g, as opposed to RSC-S’s, with 1.07 mmol/g, attributable to the partial oxidation of internal –OH groups during activation. Experimental data from hydration tests confirmed that the catalyst’s superior performance is largely attributed to its elevated specific surface area and a high density of –COOH functional groups. Under optimal reaction parameters, RSA-C-S demonstrated unparalleled catalytic efficiency in the synthesis of α-terpineol via hydration of α-pinene, achieving conversion and selectivity rates of 87.15% and 54.19%, respectively.
A New Synthetic Curcuminoid Displays Antitumor Activities in Metastasized Melanoma
Authors: Kaps Leonard , Klefenz Adrian , Traenckner Henry , Schneider Paul , Andronache Ion , Schobert Rainer , Biersack Bernhard , Schuppan Detlef
Published: November 2023

Aim: The semisynthetic derivatives MePip-SF5 and isogarcinol, which are aligned with the natural products curcumin and garcinol, were tested for their antitumor effects in a preclinical model of pulmonary melanoma metastasis. Methods and results: MePip-SF5 was almost five times more effective in inhibiting B16F10 melanoma cell proliferation than its original substance of curcumin (IC50 MePip-SF5 2.8 vs. 13.8 µM). Similarly, the melanoma cytotoxicity of isogarcinol was increased by 40% compared to garcinol (IC50 3.1 vs. 2.1 µM). The in vivo toxicity of both drugs was assessed in healthy C57BL/6 mice challenged with escalating doses. Isogarcinol induced toxicity above a dose of 15 mg/kg, while MePip-SF5 showed no in vivo toxicity up to 60 mg/kg. Both drugs were tested in murine pulmonary metastatic melanoma. C57BL/6 mice (n = 10) received 500,000 B16F10 melanoma cells intravenously. After intraperitoneal injection of MePip-SF5 (60 mg/kg) or isorgarcinol (15 mg/kg) at days 8, 11 and 14 and sacrifice at day 16, the MePip-SF5-treated mice showed a significantly (p < 0.05) lower pulmonary macroscopic and microscopic tumor load than the vehicle-treated controls, whereas isogarcinol was ineffective. The pulmonary RNA levels of the mitosis marker Bub1 and the inflammatory markers TNFα and Ccl3 were significantly (p < 0.05) reduced in the MePip-SF5-treated mice. Both drugs were well tolerated, as shown by an organ inspection and normal liver- and kidney-related serum parameters. Conclusions: The novel curcuminoid MePip-SF5 showed a convincing antimetastatic effect and a lack of systemic toxicity in a relevant preclinical model of metastasized melanoma.
Neutrophils in Inflammatory Diseases: Unraveling the Impact of Their Derived Molecules and Heterogeneity
Authors: Riaz Bushra , Sohn Seonghyang
Published: November 2023

Inflammatory diseases involve numerous disorders and medical conditions defined by an insufficient level of self-tolerance. These diseases evolve over the course of a multi-step process through which environmental variables play a crucial role in the emergence of aberrant innate and adaptive immunological responses. According to experimental data accumulated over the past decade, neutrophils play a significant role as effector cells in innate immunity. However, neutrophils are also involved in the progression of numerous diseases through participation in the onset and maintenance of immune-mediated dysregulation by releasing neutrophil-derived molecules and forming neutrophil extracellular traps, ultimately causing destruction of tissues. Additionally, neutrophils have a wide variety of functional heterogeneity with adverse effects on inflammatory diseases. However, the complicated role of neutrophil biology and its heterogeneity in inflammatory diseases remains unclear. Moreover, neutrophils are considered an intriguing target of interventional therapies due to their multifaceted role in a number of diseases. Several approaches have been developed to therapeutically target neutrophils, involving strategies to improve neutrophil function, with various compounds and inhibitors currently undergoing clinical trials, although challenges and contradictions in the field persist. This review outlines the current literature on roles of neutrophils, neutrophil-derived molecules, and neutrophil heterogeneity in the pathogenesis of autoimmune and inflammatory diseases with potential future therapeutic strategies.
Using Drosophila melanogaster to Dissect the Roles of the mTOR Signaling Pathway in Cell Growth
Authors: Frappaolo Anna , Giansanti Maria Grazia
Published: November 2023

The evolutionarily conserved target of rapamycin (TOR) serine/threonine kinase controls eukaryotic cell growth, metabolism and survival by integrating signals from the nutritional status and growth factors. TOR is the catalytic subunit of two distinct functional multiprotein complexes termed mTORC1 (mechanistic target of rapamycin complex 1) and mTORC2, which phosphorylate a different set of substrates and display different physiological functions. Dysregulation of TOR signaling has been involved in the development and progression of several disease states including cancer and diabetes. Here, we highlight how genetic and biochemical studies in the model system Drosophila melanogaster have been crucial to identify the mTORC1 and mTORC2 signaling components and to dissect their function in cellular growth, in strict coordination with insulin signaling. In addition, we review new findings that involve Drosophila Golgi phosphoprotein 3 in regulating organ growth via Rheb-mediated activation of mTORC1 in line with an emerging role for the Golgi as a major hub for mTORC1 signaling.
TEM8 in Oncogenesis: Protein Biology, Pre-Clinical Agents, and Clinical Rationale
Authors: Kareff Samuel A. , Corbett Virginia , Hallenbeck Paul , Chauhan Aman
Published: November 2023

The TEM8 protein represents an emerging biomarker in many solid tumor histologies. Given the various roles it plays in oncogenesis, including but not limited to angiogenesis, epithelial-to-mesenchymal transition, and cell migration, TEM8 has recently served and will continue to serve as the target of novel oncologic therapies. We review herein the role of TEM8 in oncogenesis. We review its normal function, highlight the additional roles it plays in the tumor microenvironment, and synthesize pre-clinical and clinical data currently available. We underline the protein’s prognostic and predictive abilities in various solid tumors by (1) highlighting its association with more aggressive disease biology and poor clinical outcomes and (2) assessing its associated clinical trial landscape. Finally, we offer future directions for clinical studies involving TEM8, including incorporating pre-clinical agents into clinical trials and combining previously tested oncologic therapies with currently available treatments, such as immunotherapy.
Emerging Role of the Mast Cell–Microbiota Crosstalk in Cutaneous Homeostasis and Immunity
Authors: Bosveld Cameron Jackson , Guth Colin , Limjunyawong Nathachit , Pundir Priyanka
Published: November 2023

The skin presents a multifaceted microbiome, a balanced coexistence of bacteria, fungi, and viruses. These resident microorganisms are fundamental in upholding skin health by both countering detrimental pathogens and working in tandem with the skin’s immunity. Disruptions in this balance, known as dysbiosis, can lead to disorders like psoriasis and atopic dermatitis. Central to the skin’s defense system are mast cells. These are strategically positioned within the skin layers, primed for rapid response to any potential foreign threats. Recent investigations have started to unravel the complex interplay between these mast cells and the diverse entities within the skin’s microbiome. This relationship, especially during times of both balance and imbalance, is proving to be more integral to skin health than previously recognized. In this review, we illuminate the latest findings on the ties between mast cells and commensal skin microorganisms, shedding light on their combined effects on skin health and maladies.
Multi-Omics Analyses Unravel Metabolic and Transcriptional Differences in Tender Shoots from Two Sechium edule Varieties
Authors: Du Zhihui , Qu Fei , Zhang Chaojun , Chen Zhilin , Li Yurong , Wen Linhong
Published: November 2023

Chaylte vine, the tender shoot of Sechium edule, is popular among vegetable consumers because of its high nutritional content, crisp texture, and unique flavor. Existing studies on the nutrient composition of chaylte vines are mostly simple chemical determinations, which have limited the breeding of specialized cultivars and the development of related industries. Using metabolomics combined with transcriptomics, this study analyzed the metabolic characteristics and related molecular mechanisms of two common varieties of chaylte vines: green-skinned (SG) and white-skinned (SW). Between the two varieties, a total of 277 differentially accumulated metabolites (DAMs) and 739 differentially expressed genes (DEGs) were identified. Furthermore, chemical assays demonstrated that the SW exhibited a higher total flavonoid content and antioxidant capacity. In conclusion, it was found that the SG samples exhibited a higher diversity of flavonoid subclasses compared to the SW samples, despite having a lower total flavonoid content. This inconsistent finding was likely due to the differential expression of the phenylalanine ammonia-lyase (PAL) and chalcone synthase (CHS) genes in the two varieties. These results laid the foundation for investigating the mechanisms involved in flavonoid regulation and the breeding of specialized S. edule cultivars for chaylte vine production.
Enhanced Tunable Properties of Strontium Barium Niobate Films on Dielectric Alumina Substrate at Microwaves
Authors: Tumarkin Andrey , Bogdan Alexey , Sapego Evgeny , Gagarin Alexander , Ivleva Ludmila , Serenkov Igor , Sakharov Vladimir
Published: November 2023

(Sr,Ba)Nb2O6 (SBN) relaxor ferroelectric thin films exhibiting nonlinear properties promising for microwave applications were grown on a polycrystalline aluminum oxide substrate for the first time. Films of good crystallinity were obtained using the sputtering technique and high-temperature annealing. For all films, a significant change in the phase composition after high-temperature treatment was observed, and annealing provided a different effect on the phase composition of films deposited at different substrate temperatures. Tunable properties of the SBN films were investigated as a function of the deposition temperature and annealing conditions using planar capacitors with microwaves. The capacitor based on the strontium barium niobate film deposited at a temperature of 950 °C and subjected to annealing demonstrates a tunability of 44% and a loss tangent of 0.009 ÷ 0.022, which is expressed in the microwave commutation quality factor of 1740. This is the first successful attempt to form planar capacitive structures based on SBN films, which reveal a commutation quality factor above 1000 for tunable microwave applications.
Advanced Corrosion and High-Temperature Protection through Surface Modification and Coatings
Authors: Fernandes Frederico Augusto Pires , Baldan Renato , de Sousa Malafaia Artur Mariano
Published: November 2023

Coatings and surface modifications have long been applied in a broad variety of areas including petrochemical, automotive, power generation, aerospace and even in the medical industry [...]
Fabrication and Characterization of Titanium Borides by Electron Beam Surface Alloying
Authors: Padikova Fatme , Nedeva Daniela , Dunchev Vladimir , Stoyanov Borislav , Ormanova Maria , Nedyalkov Nikolay , Valkov Stefan
Published: November 2023

This study shows the possibility of the fabrication of titanium borides by an alloying of a titanium substrate with boron powder via a scanning electron beam. During the electron beam alloying experiments, the speed movement of the specimens was varied, where it was 4 and 6 mm/s. The thickness of the alloyed zone formed by the lower velocity of the movement of the workpiece is greater than that of the coating obtained by the higher speed movement. The phase composition of the coatings is in the form of the TiB2 phase, as well as some amount of undissolved boron in both considered cases. In the case of the lower speed of the movement of the sample, the undissolved boron is within the whole volume of the alloyed zone, while at the higher speed movement, it is on the top of the specimen. The hardness of the obtained coatings by the higher speed of the specimen movement reached values of about 4500 HV. Considering the values of the surface alloy fabricated via the lower velocity movement of 4 mm/s, it is about 2600 HV, which is lower than that of the one obtained by the 6 mm/s speed of the sample movement. The result obtained for the friction coefficient (COF) for the specimen alloyed by the speed of the specimen motion of 4 mm/s is 0.40; the value for the coating obtained at a speed movement of 6 mm/s is 0.34. In both cases, these values are lower than that of the titanium substrate.