bluuebunny/crossref_metadata_2025 huggingface dataset:
Revisiting The Hygiene Theory; Hepatitis A And Tuberculosis Versus Atopy
Authors: Özer Yavuz , Çokuğraş Haluk
Published: June 2024

Objective: According to the hygiene hypothesis an inverse association between allergic sensitization and exposure to infections and has been reported. In this study, we investigated the relationship between atopy and tuberculosis (TB) and hepatitis A virus (HAV) infections in children.
Methods: A cross-sectional study was performed and included 39 healthy children who were followed up with TB, 40 healthy children who were with HAV seropositive, and 30 healthy children who were seronegative for HAV and tuberculin skin test (TST) response as negative. Serological tests for HAV (anti-HAV immunoglobulin G), skin prick test (SPT) investigations for the detection of atopy, and TST were carried out.
Results: The study included 39 (16 males, 23 females) with TB, 40 (16 males, 24 females) with HAV seropositive, and 30 (10 males, 20 females) healthy controls. There was no statistically significant difference between the groups in terms of age and gender (p>0.05). The SPT positivity was 28.2% (n=11) in the TB group, 15% (n=6) in the HAV group, and 30% (n=9) in the control group. There was no statistically significant difference between the groups in terms of SPT positivity (p=0.148). There was no statistically significant difference between the groups in terms of total serum IgE level (p=0.776).
Conclusion: Our study does not support the hypothesis that HAV and TB suppress the development of atopy. We think that encountering infections during the immune maturation period is a condition that is protective in the development of atopy due to multifactorial reasons
The local authority in the light of the challenges of energy transition
Authors: Korczak Jerzy
Published: June 2024

The article addresses the role of local authority units in the energy transition process, which is crucial because energy generating systems are located in a specific municipality and they contain sources of emissions exerting a negative impact on the climate. Therefore, while the State’s central authorities form the legal framework for the activities of the municipalities, counties and voivodships, it is the actual activities of the voivodship assemblies and boards, the county councils and boards and the municipal councils and executive bodies that enable the planned parameters of this negative impact to be achieved. The article takes into account the obligations arising from Union law.
The evolution of the European Union’s energy policy
Authors: Kusiak-Winter Renata
Published: June 2024

The main objective of this article is to present the evolution of the EU energy policy with particular reference to its legal conditions. It will present the directions of the changes in the EU legal regulations in recent decades in order. Central to this is an attempt to answer the question of whether the European Union’s ambitious goal to achieve climate neutrality by 2050, as proclaimed in the European Green Deal, should be viewed in terms of a continuation of the EU’s earlier energy policy, or perhaps more in terms of a kind of “revolution”, imposing the introduction of systemic changes in the energy sector of the Member States.
SIMULATING MOLECULAR OPTICAL PROPERTIES OF POLYIMIDE FOR NONVOLATILE RESISTIVE PHOTOMEMORY DEVICES
Authors:   Department of Electronic Engineering Feng Chia University Taichung, 40724, Taiwan, Tseng I-Ming , Liu Tang-Yi ,   Department of Electronic Engineering Feng Chia University Taichung, 40724, Taiwan, Pan Yi-Huan ,   Department of Electronic Engineering Feng Chia University Taichung, 40724, Taiwan, Hsu Pin-En ,   Department of Electronic Engineering Feng Chia University Taichung, 40724, Taiwan, Ou Wei-Cheng ,   Department of Electronic Engineering Feng Chia University Taichung, 40724, Taiwan, Jiang Pei-Ying ,   Department of Electronic Engineering Feng Chia University Taichung, 40724, Taiwan, Yang Wen-Luh ,   Department of Electronic Engineering Feng Chia University Taichung, 40724, Taiwan
Published: June 2024

In this study, the focus was on utilizing the polyimide (PI) thin film as a resistive conversion layer for organic polyimide-based resistive random-access memory (ReRAM) applications. We utilized the 3D molecular editor WebMO to manipulate and analyze the structures of Aromatic-PI and Quinoid-PI molecules. The molecular chain length, molecular weight, and HOMO/LUMO molecular orbitals were investigated to gain insights into the fundamental properties of PI molecular structures. The analysis revealed that the Quinoid-PI molecule exhibited a shorter molecular chain compared to Aromatic-PI, attributed to the inability of the cyclic structure in Quinoid-PI to maintain a planar conjugated structure, resulting in an uneven overall structure and reduced molecular chain length (Norcorss, 1988). The research results demonstrate that the optical energy gap of Aromatic-PI remains constant regardless of the number of molecular bonds, with a value of approximately 3.2661 eV. In contrast, for Quinoid-PI, the optical energy gap undergoes a significant decrease as the number of molecular bonds ranges from 1 to 5. As the bond count increases to 20~23, the change in the optical energy gap gradually diminishes, ultimately resulting in an optical energy gap of 0.6932 eV. This observation indicates that longer molecular chains composed of Aromatic-PI act as insulators, while Quinoid-PI transforms into a low-energy gap conductor.
STRUCTURAL ANALYSIS OF A LIGHTWEIGHT ELECTRIC VEHICLE CHASSIS
Authors:   PhD (Associate Professor), Mechanical Engineering Department, Obafemi Awolowo University, Nigeria, Omidiji Babs, V. , Daniyan Ayodele, A. ,   PhD (Assistant Professor), Materials Science and Engineering Department, Obafemi Awolowo University, Nigeria, Owolabi Hakeem, A. ,   PhD (Associate Professor) Mechanical Engineering Department, Obafemi Awolowo University, Nigeria, Oluwasegun Kunle, M. ,   PhD (Research Associate) Department of Mechanical and Manufacturing Engineering, University of Manitoba, Winnipeg, Manitoba, Canada, Egbebunmi Daniel, ,   M.Sc. (Graduate Student) Department of Mechanical and Materials Engineering, University of Nebraska-Licoln, 900N. 16th St, Lincorn, NE, 68588, USA, Fabunmi Olusegun, E. ,   M.Sc. (Graduate Student) Mechanical Engineering Department, Obafemi Awolowo University, Nigeria
Published: June 2024

This study presents a comprehensive investigation into the design and structural analysis of lightweight chassis for electric vehicles. A chassis needs to be able to withstand twist, shock, vibration, and other stresses caused by acceleration, braking, road condition, and shock initiated by other parts of a vehicle. It should carry a maximum load under all operating conditions. Two materials, 304L steel, and Ti-6AL-4V alloy were evaluated, with parameters such as total deformation, equivalent stress, and equivalent elastic strain under consideration. The outcome of the Finite Element Analysis revealed that Ti-6AL-4V can withstand higher stresses than 304L Steel. By investigating the static behaviors of the chassis under static loading due to weight and overload conditions, Ti-6AL-4V was chosen as a suitable replacement for a 304L Steel chassis.
BASIC ANXIETY IN JANE AUSTEN’S PRIDE AND PREJUDICE AND EMMA
Authors:   Faculty of Arts, Humanities and Social Sciences, University of Limerick, Limerick, Ireland, Djelloul Hana
Published: June 2024

This paper delves into the inner conflict of Elizabeth Bennet and Emma, the heroines of Jane Austen’s Prejudice and Prejudice and Emma. The study uses Karen Horney’s psychoanalytic social theory of basic anxiety that emphasizes the influence of childhood experiences and the impact of socialization on an individual’s psychological development. It examines certain instances in the heroines’ early experiences that shape their adult identity and self-knowledge. The analysis reveals that those heroines are highly influenced by their parents or chaperones, who themselves may suffer from neurotic struggles that hinder their ability to properly provide care and support for their children. Therefore, an analysis of those parents and chaperones is provided to see to what extent their psychological conflicts preoccupy their behavior towards the heroines.
When the captor is captive
Authors: Dufoix Stéphane
Published: June 2024

In the 1970s, the Malaysian sociologist Syed Hussein Alatas proposed an analysis to account for the teaching of social sciences in the developing world, and especially in Asia. He coined the phrase “captive mind” to describe those students whose training was biased towards Western theories, concepts, meanings and authors taught to them by “captor minds”, the latter being either Asian social science instructors reproducing what they had been taught in the West or Western teachers merely transplanting their “universal” sociology to students wherever they may be. Even if Alatas wrote in 1974 that “there is no counterpart of the captive mind in the West”, we may wonder whether, in the past and also nowadays, sociological teaching in the West has not suffered from the same drawback, almost constantly reproducing both the same kind of visual bias (hyperopia in the South and myopia in the North) and the same form of almost continuous reliance on the same canon. The aim of this paper is to demonstrate that this “hegemonic” gaze also relies on a specific end of teaching in the West, examines its effects and proposes an alternative centered on a new understanding of universalism.
Preparing Educators and Students at Higher Education Institutions for an AI-Driven World
Authors: Magrill Jamie , Magrill Barry
Published: June 2024

The rapid advancement of artificial intelligence technologies, exemplified by systems including Open AI’s ChatGPT, Microsoft’s Bing AI, and Google’s Bard (now Gemini 1.5Pro), present both challenges and opportunities for the academic world. Higher education institutions are at the forefront of preparing students for this evolving landscape. This paper examines the current state of AI education in universities, highlighting current obstacles and proposing avenues of exploration for researchers. This paper recommends a holistic approach to AI integration across disciplines, fostering industry collaborations and emphasizing the ethical and social implications of AI. Higher education institutions are positioned to shape an educational environment attuned to the twenty-first century, preparing students to be informed and ethical contributors in the AI-driven world.
MOOC para formação continuada de professores da Educação Básica em pensamento computacional
Authors: Guarda Graziela Ferreira , Pinto Sérgio Crespo Coelho da Silva
Published: June 2024

A partir da aprovação da Resolução N° 1 de 2022, a Computação integra formalmente a Base Nacional Comum Curricular (BNCC). A normativa estabelece que os Estados, Municípios e o Distrito Federal devem estabelecer parâmetros e abordagens pedagógicas de implementação do Pensamento Computacional (PC) na Educação Básica. Nessa direção, considerando a necessidade de formação continuada docente na temática, o presente estudo apresenta a estrutura pedagógica de um curso on-line, massivo e aberto (MOOC) para professores da Educação Básica. O intuito do curso foi capacitá-los quanto aos conceitos e aplicações do PC buscando identificar dificuldades e barreiras no aprendizado. Com metodologia quantitativa, o curso foi realizado com 192 professores. Os resultados mostraram que tanto a organização pedagógica, quanto os materiais didáticos são adequados para a formação em PC e que a aquisição dos conteúdos ocorreu de forma satisfatória.
ASEAN Non-Interference Under Heavy Pressure: Is It Change or Crises for ASEAN Peace?
Authors: Spastyono Jeko , Malik Ichsan , Wahyudi Bambang
Published: June 2024

This paper intends to join the discussion over the heavily pressured ASEAN’s non- interference. With a qualitative approach, this paper investigate where the pressure comes from and whether non-interference actually harms ASEAN. Utilizing the medical analogy, “the dose makes the poison,” and Acton’s wisdom on power, the paper argue that the non-interference harm and critics inducing to ASEAN is a result of its excessive uses rather than the principle itself harmful. Avoiding, delaying, and brushing issues aside behind non-interference becomes a comfortable refuge for ASEAN when faced with difficult challenges. ASEAN indeed needs to change. However, given ASEAN’s diverse political, cultural, and language differences, eliminating non-interference influence in ASEAN is an outrageous deliberation. The principle is not poisonous with the right prescription. Therefore, as conclusion the paper advocate the creation of a formal forum that can serve as a formal means to brainstorm solutions for members’ taboo predicament that could preserve member states freedom to decide, rather than dictating one, to control the dosage of non-interference needed in the ASEAN system. Like a family, ASEAN member states can use the forum to convince each other’s that there are better solutions for their predicament and advance the region together.
Paradiplomasi Jawa Barat Melalui Kerja Sama Sister Province antara Jawa Barat dan Souss-Massa
Authors: Faishal Alvin , Yulianti Dina
Published: June 2024

Kerja sama luar negeri merupakan bagian integral dari suatu hubungan antarnegara di seluruh dunia. Bentuk dari kerja sama luar negeri yang dikenal adalah paradiplomasi. Di Indonesia, praktik paradiplomasi mulai berkembang pasca tahun 1998, pemerintah pusat pun mendukung hubungan kerja sama dalam praktik diplomasi tersebut dengan mengeluarkan beberapa regulasi- regulasi demi kelancaran paradiplomasi. Praktik paradiplomasi di Indonesia terdapat dua bentuk kerja sama yaitu sister city dan sister province. Artikel ini mendeskripsikan proses dan bentuk paradiplomasi antara Jawa Barat dan Sous-Massa (Maroko) yang telah menjalin sister province sejak 2017 hingga sekarang. Penelitian ini menggunakan metode deskriptif kualitatif untuk mengumpulkan dan menganalisis data, melalui studi literatur yang didapatkan dari website, jurnal, dan dokumen resmi dengan fokus pada telaah pokok bahasan secara rinci dan komprehensif. Temuan penelitian ini berkontribusi pada pemahaman pentingnya paradiplomasi dan soft power dalam membentuk hubungan internasional, serta potensi peningkatan kerja sama bilateral antara Indonesia dan Maroko di masa yang akan datang.
Dampak Advokasi International Non-Governmental Organization pada Pasar Foie gras di Eropa
Authors: MAULIDINA NURUL QOMARIYAH , Siregar Wahidah Zein Br
Published: June 2024

Penelitian ini membahas mengenai advokasi yang dilakukan oleh beberapa International Non-Governmental Organization (INGO) yang berfokus pada pembelaan terhadap hak-hak hewan serta dampaknya terhadap pasar di Eropa. INGO-INGO ini mengecam adanya praktik kekejaman terhadap hewan seperti yang terjadi dalam proses produksi, salah satu makanan tertua di Eropa yang juga merupakan gastronomi Prancis. Mereka melakukan beberapa advokasi untuk mengungkap kekejaman produksi kepada masyarakat luas. Advokasi yang dilakukan oleh INGO-INGO tersebut telah mendapat banyak keberhasilan. Beberapa pihak, misalnya, mulai berhenti menyediakan dan mengkonsumsi sehingga hal tersebut mempengaruhi pasar di Eropa. Guna menganalisis dampak advocacy tersebut, peneliti mengumpulkan data melalui studi dokumen dari berbagai sumber yang relevan. Penelitian ini menggunakan pendekatan kualitatif dengan penyajian data secara deskriptif. Konsep yang digunakan adalah INGO sebagai aktor non-negara yang juga memiliki peran besar dalam menangani permasalahan pada kesejahteraan hewan. Hasil penelitian menunjukkan bahwa advokasi yang dilakukan INGO menjadi salah satu faktor yang memberikan dampak pada pasar di Eropa. Beberapa data menunjukkan penurunan jumlah produksi Foei gras secara signifikan.
ЗАСОБИ ТА МЕТОДИ АВТОМАТИЗАЦІЇ КОНТРОЛЮ АНТРОПОМЕТРИЧНИХ ПОКАЗНИКІВ ДІТЕЙ В ЛІКАРСЬКІЙ ПРАКТИЦІ
Authors: Вовянко Світлана , Козяр Василь , Колбасін Максим
Published: June 2024

Мета роботи: Аналіз засобів та методів автоматизації контролю антропометричних показників дітей, що можуть бути використані у лікарській практиці, для створення додатку із застосуванням автоматизованих засобів збору, збереження, аналізу і оцінки антропометричних показників для своєчасної корекції відхилень шляхом надання індивідуальних рекомендацій. Актуальність: Розрахунок антропометричних даних дитини включає в себе значну кількість показників. Лікар повинен проводити заміри до 20 відповідних показників та вести їх статистичний контроль, для кожної дитини індивідуально. Але, як показує практика, ця методика є досить складною та вимагає витрат великої кількості робочого часу. Тому автоматизація покликана зробити контролюючу та лікувальну методики більш ефективними. Новизна: Разом з оглядом наявних методах контролю антропометричних даних ми пропонуємо автоматизацію процесу контролю нутрієнтів, які споживає дитина під час харчування. Як метод корекції відхилень, згідно з наказом №1073 від 03.09.2017, ефективно використовують індивідуалізовану дієтотерапію з налаштуванням згідно вікових норм. Розробка та створення спеціальної інформаційно-комунікативної медичної системи здатна суттєво спростити роботу лікаря. Спеціаліст буде мати змогу проводити контроль за допомогою будь якого девайсу: телефону, комп’ютера, ноутбука. Це важливо в наших реаліях, адже не завжди лікар буде мати доступ до сучасних пристроїв, але майже кожен має смартфон. Саме тому під час розробки програмного застосунку, треба взяти до уваги програмне середовище, яке має давати змогу без зміни початкового коду, запускати програми на різних операційних системах. Здебільшого в дитячому віці проблему становить зайва маса дитини, що є причиною великої кількості соматичних захворювань. Розрахунковий модуль для батьків може бути дієвим і зручним інструментом вибору нутрієнтів, які необхідні дитині для нормального розвитку. Так само, розрахунковий модуль, батьки зможуть запускати з власного смартфону та проводити розрахунок нутрієнтів для своєї дитини. Це набагато зручніше, враховуючи, що в цьому модулі буде блок корекції, де лікар зможе змінювати норму кількості білків, жирів та вуглеводів, які треба спожити. Результати цього дослідження допоможуть не тільки виявити можливості впровадження передових технологій у медичну практику для моніторингу здоров'я дітей, а й визначити перспективні напрямки майбутніх досліджень у цій сфері.
ПЕРСПЕКТИВИ ВИКОРИСТАННЯ ЛАЗЕРІВ В МЕДИЧНІЙ ПРАКТИЦІ
Authors: Колнаузов Іліан , Богомолов Микола , Грибан Олександр
Published: June 2024

Активний розвиток лазерних технологій призводить до їх широкого застосування у біомедичній сфері. У різних галузях медицини, таких як офтальмологія, кардіологія, стоматологія, лабораторна діагностика, хірургія, тканинна інженерія та онкологія, використання лазерів стає все більш поширеним. Дослідження показують, що лазерне випромінювання може позитивно впливати на організм людини, зокрема сприяти поліпшенню процесу загоєння ран, лікуванню карієсу, зниженню рівня стресу для пацієнтів, забезпеченню високої точності у хірургічних втручаннях та відсутності болісних відчуттів. Однією з головних переваг лазерної терапії є здатність точно та мінімально інвазивно впливати на проблемні ділянки без пошкодження навколишніх тканин. Це дозволяє зменшити ризик кровотечі, запобігти появі рубців та забезпечити швидше загоєння. Крім того, лазерна терапія часто асоціюється з меншим дискомфортом для пацієнта під час лікування та скорочує тривалість відновлення після процедур. Особливо важливе застосування лазерної технології у стоматологічних процедурах, де вона сприяє прискоренню регенерації тканин пародонта та швидкому загоєнню ясенних тканин. Новітні світлові методи відкривають перед медичною галуззю нові перспективи у покращенні якості медичного обслуговування та забезпеченні більш ефективного лікування пацієнтів. Завдяки постійним дослідженням та вдосконаленню технологій, можна очікувати подальший розвиток застосування лазерів у медицині, що дозволить досягти ще більших успіхів у лікуванні та діагностиці різноманітних захворювань, забезпечуючи пацієнтам більш швидке та ефективне відновлення здоров'я. У статті також досліджується вплив лазерної технології на розвиток стоматологічної практики та біомедичної інженерії.
Substituent Effects in the Photophysical and Electrochemical Properties of meso-Tetraphenylporphyrin Derivatives
Authors: Millheim Alexandra Cruz , Ponzano Enric , Moyano Albert
Published: June 2024

Visible-light photocatalysis, particularly in its application to organic synthesis, has experienced a big renaissance in the past decade. The rational design of new photocatalysts with designed and improved photocatalytic properties, that at the same time circumvents the necessity of using scarce and toxic transition metals, will predictably play a key role in photocatalysis in the next few years. Although free-base porphyrins were identified some years ago as a promising, easily accessible and easily tunable class of organic photoredox catalysts, a systematic study on the effect of the electronic nature and of the position of the substituents on both the ground-state and the excited-state redox potentials of these compounds is still lacking. We have prepared a set of known functionalized derivatives of meso-tetraphenyl porphyrin containing different substituents either in one of the meso-positions or at a beta-pyrrole carbon and we have determined their ground- and (singlet) excited-state redox potentials. This survey has led us to conclude that the introduction of a carbonyl group at the beta-pyrrolic position strongly increases the facility of the monoelectronic reduction of the porphyrin both in the ground state and in the singlet excited state. We have also prepared a second set of four previously unknown benzoyl derivatives of meso-tetraphenylporphyrin, and we have confirmed the validity of our conclusions.
LINC01270 Regulates the NF-κB-Mediated Pro-inflammatory Response via the miR-326/LDOC1 Axis in THP-1 Cells
Authors: Arab Imene , Lim Su-Geun , Suk Kyoungho , Lee Won-Ha
Published: June 2024

Long intergenic noncoding (LINC)01270 is a 2278 bp transcript belonging to the intergenic subset of long noncoding (lnc)RNAs. Despite increased reports of LINC01270’s involvement in different diseases, evident research on its effects on inflammation is yet to be achieved. In the present study, we investigated the potential role of LINC01270 in modulating the inflammatory response in the human monocytic leukemia cell line THP-1. Lipopolysaccharide treatment upregulated LINC01270 expression, and siRNA-mediated suppression of LINC01270 enhanced NF-kB activity and the subsequent production of cytokines IL-6, IL-8, and MCP-1. Interestingly, the knockdown of LINC01270 downregulated expression of leucine zipper downregulated in cancer 1 (LDOC1), a novel NF-kB suppressor. An analysis of the LINC01270/micro-RNA (miRNA)/protein interactome profile identified miR-326 as a possible mediator. Synthetic RNA agents that perturb the interaction among LINC01270, miR-326, and LDOC1 mRNA mitigated the changes caused by LINC01270 knockdown in THP-1 cells. Additionally, a luciferase re-porter assay in HEK293 cells further confirmed that LINC01270 knockdown enhances NF-kB activation, while its overexpression has the opposite effect. This study provides insight into LINC01270’s role in modulating inflammatory responses to lipopolysaccharide stimulation in THP-1 cells via miR-326/LDOC1 axis which negatively regulates NF-kB activation.
Evaluation of a Phytogenic Feed Additive with Essential Oils and Plant Extracts on Growth Performance in Auction-Derived Beef Steers
Authors: Delver Justin J. , Rusche Warren C. , Smith Zachary K.
Published: June 2024

This study used 10 replicate pens per treatment in a randomized complete block design and each pen contained 8 steers (initial BW = 305 ± 30.4 kg; n=80 steers/treatment) to determine if a phytogenic feed additive (PFA) with essential oils and plant extracts (PHYTOsolvan 200; DOSTOFARM, Westerstede, Germany) influences measures of growth or growth efficiency during the feedlot receiving phase in auction-derived beef steers. No steers were removed from the study; one steer from the control treatment was treated for respiratory disease. No mortality was noted in the present experiment. No appreciable differences were noted for BW, ADG, DMI, or feed conversion efficiency from d 1 to 29, 29 to 53, or during the cumulative receiving period (P ≥ 0.12). Performance based NEm and NEg were not influenced by dietary treatment (P ≥ 0.79). The ratio of observed-to-expected dietary net energy was not impacted by dietary treatment (P ≥ 0.71). These were healthy, high-growth potential Northern Plains steers. There was minimal morbidity (0.63%) and no mortality noted during the 53 d receiving study. Steers performed well and met growth performance expectations (the ratio of observed-to-expected NEm = 1.00), hence, it was not anticipated that the phytogenic compound would appreciably influence growth or health outcomes under the conditions of this experiment.
Knockdown of DJ-1 Resulted in a Coordinated Activation of the Innate Immune Antiviral Response in HEK293 Cell Line
Authors: Zohar Keren , Linial Michal
Published: June 2024

PARK7, also known as DJ-1, plays a critical role in protecting cells by functioning as a sensitive oxidation sensor and modulator of antioxidants. DJ-1 acts to maintain mitochondrial function and regulate transcription in response to different stressors. In this study, we showed that cell lines vary based on their antioxidation potential at basal conditions. The transcriptome of HEK293 cells was tested following knockdown (KD) of DJ-1 using siRNAs which reduced the DJ-1 transcripts to only 12% of the original level. We compared the expression levels of 14k protein-coding transcripts, and 4.2k non-coding RNAs relative to control cells treated with non-specific siRNAs. Among the coding genes, ~200 upregulated differentially expressed genes (DEGs) signified a coordinated antiviral innate immune response. Most genes were associated with regulation of type 1 interferons (IFN) and induction of inflammatory cytokines. About a quarter of these genes were also induced in cells treated by non-specific siRNAs that were used as a negative control. Beyond the antiviral response, 114 genes were specific to KD of DJ-1 with enrichment in RNA metabolism and mitochondrial functions. A smaller set of downregulated genes (58 genes) were associated with dysregulation in membrane structure, cell viability, and mitophagy. We propose that KD of DJ-1 diminish its protective potency against oxidative stress, rendering the cells labile and responsive to dsRNA signal by activation of a large number of genes, many of which drive apoptosis, cell death, and inflammatory signatures. The KD of DJ-1 highlights its crucial role in regulating genes associated with antiviral responses, RNA metabolism, and mitochondrial functions, apparently through alteration in STAT activity and downstream signaling. Given that DJ-1 is highly expressed in metastatic cancers, targeting DJ-1 could be a promising therapeutic strategy where manipulation of DJ-1 levels may reduce cancer cell viability and enhance the efficacy of cancer treatments.
Is Left Ventricle Global Longitudinal Strain by Two-Dimensional Speckle Tracking Echocardiography Useful at Detection of Subclinical Myocardial Dysfunction in Patients After Coronavirus-2019 infection?
Authors: da Nóbrega Borges José Victor , Abdel Correia Leila Samira , Babu Kiran , Burra Sahithi , Ahmed Shaikh Muhammad , Majid Shaik Abdul , Reddy Takkasila Mahitha , Hiteshkumar Shah Kavya , Jashvantbhai Patel Karma
Published: June 2024

Introduction: The disease caused by Coronavirus-2019 (COVID-19) was initially described in December 2019. Severe acute respiratory syndrome type 2 (Sars-Cov-2) is responsible for an important multisystem inflammatory spectrum. Cardiovascular conditions have been reported with an estimated frequency of 8-28%. In this context, transthoracic echocardiography associated with the analysis of the two-dimensional Global Longitudinal Strain (GLS) of the left ventricle derived from Speckle Tracking emerges as a promising modality. Objective: This study aims to evaluate the applicability of GLS and segmental deformity assessment in detecting subclinical myocardial dysfunction in patients that recovered from COVID-19 infection. Methods: The observational study involved 18 patients (mean age 52 years) with recent evidence of COVID-19 infection that underwent detailed echocardiographic evaluation with GLS, and cardiac magnetic resonance (CMR) according to segmental assessment results. The degree of correlation between the methods was analyzed and a systematic literature review was also conducted. Results: The mean left ventricular ejection fraction (LVEF) was 57.50 ± 9.98%. Only 16.6% of patients had reduced LVEF. The average GLS was – 18.70 ± 3.54% and in 44% of cases only one myocardial segment was affected, particularly the inferolateral basal. CMR revealed inflammatory cardiomyopathy. Discussion: Subclinical myocardial involvement is associated with major adverse cardiac events. Literature review supports the use of GLS for detecting early cardiac involvement. Conclusion: Speckle-tracking echocardiography has been shown to have clinical utility in a variety of settings and to offer superior prognostic value with a potential to enhance subclinical detection of myocardial changes in patients after COVID-19 infection.
Mid-level medical personnel work organization as a factor of enhancing medical institution efficiency.
Authors:   SBIH Vorohobov’s City Clinical Hospital № 67 MHD, Afonina L. A. , Skoda A. S. ,   SBIH Vorohobov’s City Clinical Hospital № 67 MHD, Podryadova N. F. ,   LLC Medeum, Angelovsky A. S. ,   Federal State Budget Educational Institution of Higher Education M. V. Lomonosov Moscow State University, Shitova Yu. A. ,   LLC Medeum
Published: June 2024

The shortage of mid-level medical personnel is one of the most urgent problems of healthcare system in the Russian Federation and affects negatively the efficiency of hospitals. This deficit is partially caused by a high burden on mid-level medical staff and their necessity to provide a number of non-specific non-medical activities. This leads to the medical services quality reduction, negatively affects the motivation of employees and decreases employment in this area. Purpose of this study is to identify the key problems of the organization of labor of mid-level medical staff and the formation of a new concept of labor organization taking international experience into account. Materials and methods. The research is based on the analysis of existing academic literature, sources of official statistical data, regulatory documents, theoretical and practical aspects of labor management and organization in the field of healthcare, the study of relevant international experience in order to identify innovative approaches and methods of labor organization. Results. According to the research the main problems of organizing the work of mid-level medical personnel include shortage of this personnel, its high workload, problems of regulation etc. The reasons for the shortage of mid-level medical specialists are identified: low wages, dissatisfaction with working conditions, low prestige of the medical profession. A system for delegating non-medical duties of mid-level medical personnel to non-medical assistants is introduced as the most effective way to solve these problems based on examples from international experience. According to this approach the tasks of assistants should include non-medical care of patients, work with documents, communications, cleaning, preparing rooms, and so on. International experience shows that assisting staff increases the efficiency of medical organizations and reduces the burden on mid-level medical staff. Findings. The need has been identified for further elaboration of the concept of labor organization in the healthcare system of the Russian Federation based on the principle of delegating non-medical duties of mid-level medical staff to non-medical assisting staff.
Screening of chronic kidney disease in children using machine learning algorithms.
Authors:   FGOU VO “Samara State Medical University” of the Ministry of Health of the Russian Federation, Kolsanov A.V. , Sedashkina O. A. ,   FGOU VO “Samara State Medical University” of the Ministry of Health of the Russian Federation, Postnikov M. A. ,   FGOU VO “Samara State Medical University” of the Ministry of Health of the Russian Federation, Makovetskaya G.A. ,   FGOU VO “Samara State Medical University” of the Ministry of Health of the Russian Federation, Romadanova E. M. ,   GBUZ “Samara Regional Clinical Hospital named after V. D. Seredavin”, Koposova E. V. ,   GBUZ “Samara Regional Clinical Hospital named after V. D. Seredavin”, Frolova E. I. ,   GBUZ SO “Sergievskaya CRB”; Ministry of Health of the Russian Federation, Shchepkina E. V. ,   Russian Presidential Academy of National Economy and Public Administration (RANEPA)
Published: June 2024

Late diagnosis of chronic kidney disease (CKD) in children is common. Among the main reasons: lack of awareness among parents and medical personnel, nonspecific symptoms, and difficulties in carrying out diagnostic procedures in children. This leads to serious health consequences for children, including progression of the disease and the need for long-term dialysis therapy or kidney transplantation. P u r p o s e : to identify signs and symptoms in children that have a non-linear impact on CKD using a decision tree (DT) algorithm. M a t e r i a l s a n d m e t h o d s of the study: data were obtained from a single-center prospective cohort study (2011–2022) involving 128 children with CKD stages 1–4 and 30 children in the control group aged 0 to 18 years. An analysis of the anamnesis, hereditary factors, the early period of the child’s development, the results of clinical, paraclinical and genetic examination was carried out. The model was built using a machine learning (ML) algorithm using the decision tree (DR) method. R e s u l t s . The decision tree model identified three variables that jointly influence CKD: protein loss, red blood cells in the urine, and the T598T polymorphic marker of the IL4 gene. The model predicts CKD on the training set with an accuracy of 98.9% [97.3; 100.0]%, sensitivity 97.8% [95.1; 100.0]%, specificity 100.0% [100.0; 100.0]%, ROC-AUC = 100.0% [99.9; 100.0]%.; describes 95.7% [89.1; 100.0]% variance. The resulting regression model is of excellent quality (>90%), because ROC-AUC is 0.98 on the test sample. During the study, the value of the cut-off point (cut-off) of the VLP was determined, which is equal to 0.5. C o n c l u s i o n s . Biomarkers have been identified that will help primary care physicians identify CKD in children at early stages of development. These variables can be easily examined in outpatient and primary care settings. This information may help raise awareness of the diagnosis. Healthcare providers can form groups of patients for more detailed examination, which will reduce the likelihood of wasted time and improve early detection of diseases.
Methodological approaches to measuring public and individual health as a medical and social resource and the potential of society.
Authors:   Federal State Budgetary Educational Institution of Higher Education «Orenburg State Medical University» of the Ministry of Health of the Russian Federation, Omarova D. S. , Begun D. N. ,   Federal State Budgetary Educational Institution of Higher Education «Orenburg State Medical University» of the Ministry of Health of the Russian Federation, Bulycheva E. V. ,   Federal State Budgetary Educational Institution of Higher Education «Orenburg State Medical University» of the Ministry of Health of the Russian Federation, Duisembayeva A. N. ,   Federal State Budgetary Educational Institution of Higher Education «Orenburg State Medical University» of the Ministry of Health of the Russian Federation, Borshchuk E. L. ,   Federal State Budgetary Educational Institution of Higher Education «Orenburg State Medical University» of the Ministry of Health of the Russian Federation
Published: June 2024

One of the main indicators in healthcare is public and individual health. However, despite a comprehensive, in-depth and long-term study of the theoretical component of «health», there is still a need to define its universal and effective criteria, methodological approaches to measuring public and individual health as a medical and social resource and the potential of society. The purpose to analyze the published data in the scientific literature on methodological approaches to measuring public and individual health as a medical and social resource and the potential of society. Research methods. The collection, study and analysis of available information sources in the scientometric databases WoS, Scopus included in the list approved by the Higher Attestation Commission under the Ministry of Education and Science of the Russian Federation. The search for scientific articles was carried out in the electronic databases PubMed, Google Scholar, eLibrary.RU by keywords. 47 articles were included in the review for analysis. The results of the study. The analysis of the literature data has shown the need to systematize and adapt existing methods of assessing public and individual health into a single multi-level assessment system. Indicators of public and population health should reflect all aspects of the well-being of the population. This is evidenced by the published data on measuring instruments, which have shown their effectiveness, but have a disadvantage – the lack of complexity, or the complexity claimed in the research is not complete. Conclusion. Currently, there is a whole arsenal of methodological approaches to measuring public and individual health. To assess it as a medical and social resource and the potential of society, the use of individual indicators does not allow a comprehensive assessment of public health, in addition, the lack of monitoring of an integrated assessment of public health makes it difficult to apply operational management decisions in the field of healthcare.
Novel Dual Bicolumnar Fibula Graft Reconstruction of Distal Humerus in Pediatric Patients After Massive Bone Resection
Authors: Mustafa Mohamed Abdel Rahman , Lam Aaron , Rodriguez Ariel N. , El Masry Ayman Mohammad , Azmy Sherif Ishak , Abdel Aal Maghrabi Mohamed , Abdelgawad Amr Atef
Published: June 2024

Case:

We describe 2 case studies, involving a 10-year-old girl with an aneurysmal bone cyst and a 12-year-old adolescent boy with Ewing sarcoma. The patient with Ewing sarcoma was previously managed with wide surgical excision and fibular graft reconstruction and subsequently experienced significant graft resorption, hardware failure, and fracture 24 months after operation. A revision limb salvage attempt was undertaken. In both cases, fibular strut grafts were harvested and fixed with intramedullary k-wires to recreate the medial and lateral columns of the distal humeral triangle.

Conclusion:

The technique achieved complete osseous integration, structural support, and functional restoration of the elbow in both cases, with good functional outcomes.
Proximal Tibia Fracture Through Suture Augmentation Sites Following ACL/MCL Repairs
Authors: Feeley Scott M. , Kamali Arash , Colantonio Donald F. , Renninger Christopher H.
Published: June 2024

Case:

A 35-year-old man sustained a proximal tibia fracture from a low-energy mechanism 1 year after anterior cruciate and medial collateral ligament repairs with suture augmentation (SA). The fracture propagated through both tibial SA anchor sites. Following intramedullary tibial nailing, he returned to his prior level of function.

Conclusion:

While complications of SA for ligamentous procedures are rare, these techniques are being implemented more frequently and the full complication profile is yet to be determined. Our report documents a new complication and potential risk factors that surgeons should consider when performing SA for multiligament knee surgery in active individuals.
US Army Corps of Engineers (USACE) Wave Information Study : 2021 annual update
Authors: Hall Candice , Jensen Robert , Collins Clarence , Hesser Tyler , Brown Mitchell
Published: June 2024

This Coastal and Hydraulics Engineering Technical Note (CHETN) describes the 2021 Wave Information Study (WIS) annual update. Within this CHETN, we summarize the WIS input data, explain the model technologies, detail the quality control / quality assurance (QA/QC), and provide statistical evaluation of the 2021 WIS estimates as compared to in situ buoys and remotely sensed satellite altimeter data.
Adsorption, Kinetic and Thermodynamic Studies for the Adsorption of Cadmium onto Combination of Chitosan and Coffee Ground Activated Carbon
Authors: Nurhidayanti Nisa , Riyadi Agus
Published: June 2024

The presence of cadmium in water due to its natural mobility can cause the nature of the water to become toxic and threaten the surrounding ecosystem when it accumulates in the food chain. The aim of this study was to investigate the maximum adsorption capacity using an isothermal model, to determine the rate of adsorption kinetics using chitosan and coffee powder adsorbents in reducing cadmium concentrations in industrial wastewater, and to investigate its thermodynamic magnitude. The research method was applied with laboratory experiments followed by quantitative data analysis to determine the isothermal model and adsorption kinetics. The results showed that the adsorption isotherm follows the Langmuir isotherm model with a correlation coefficient of 0.9970 and a maximum adsorption capacity of 0.7546 mg.g-1, which indicates that the chemical adsorption occurs in a monolayer, where the  adsorption sites are homogeneously distributed with the adsorption energy. Permanent and negligible interactions between cadmium molecules (adsorbate) and adsorbent. Thus the pseudo second order kinetic model is a better way to explain the reaction rate for cadmium in combination chitosan and coffee ground activated carbon. Negative ΔGo values indicate that the adsorption reaction takes place spontaneously, ΔHo of 0.3467 indicates an endothermic reaction, and ΔSo of 3.5296 indicates an increase in the randomness of the adsorption process at the adsorbent interface and cadmium during adsorption.
Peningkatan Kualitas Kayu Lapis (Plywood) Skala Ekspor Menggunakan Metode Seven Tools dan New Seven Tools
Authors: Devani Vera , Fauziah Ifa
Published: June 2024

Perusahaan kayu lapis ini adalah perusahaan yang memproduksi kayu lapis, blockboard, dan polyester. Dalam proses pembuatan kayu lapis masih ditemukan produk cacat dengan persentase rata-rata dari bulan September 2020 sampai dengan februari 2021 (23,94%) melebihi standar perusahaan (2,5%) sehingga tidak dapat di ekspor. Metode yang digunakan untuk memecahkan permasalahan kualitas pada penelitian ini adalah Metode Seven Tools. Metode Seven Tools adalah metode yang digunakan untuk memecahkan permasalahan kualitas dalam proses produksi. Metode New Seven Tools merupakan metode untuk memetakan permasalahan kualitas secara terstruktur untuk mempermudah dalam pengambilan keputusan terhadap tindakan usulan perbaikan yang diberikan. Penelitian ini bertujuan untuk menentukan cacat dominan yang menjadi prioritas perbaikan kualitas, menentukan penyebab kecacatan dominan dan hubungan sebab-akibat, menentukan usulan perbaikan yang tepat untuk meminimasi cacat dominan. Berdasarkan hasil penelitian yang dilakukan, dapat disimpulkan bahwa jumlah cacat dominan terdapat pada jenis cacat lekang samping dengan jumlah cacat sebesar 18.976 dengan presentase cacat sebesar 61,17%. Jenis cacat dominan berikutnya adalah gembung dengan jumlah cacat sebesar 7.721 dengan presentase 24,89%. Faktor penyebab cacat lekang samping dan gembung yang paling berpengaruh terhadap kualitas kayu lapis adalah kadar air pada material kayu 21%, panas platen pada mesin hot press tidak rata, serta lem kayu tidak merata pada lembaran kayu dengan skor 9. Adapun usulan yang diberikan dan dapat diterapkan kepada perusahaan PT. Asia Forestama Raya adalah memberikan pelatihan kepada operator setiap tiga bulan, melakukan pengecekan dan perawatan mesin setiap bulan, mengganti roll pada mesin glue spreader serta melakukan inspeksi bahan baku setiap hari kerja.
Patch and matrix striatonigral neurons differentially regulate locomotion
Authors: Cai Huaibin , Dong Jie , Wang Lupeng , Sullivan Breanna , sun lixin , Chang Lisa , Smith Victor Martinez , Ding Jinhui , Le Weidong , Gerfen Charles
Published: June 2024

The striatonigral neurons are known to promote locomotion1,2. These neurons reside in both the patch (also known as striosome) and matrix compartments of the dorsal striatum 3-5. However, the specific contribution of patch and matrix striatonigral neurons to locomotion remain largely unexplored. Using molecular identifier Kringle-Containing Protein Marking the Eye and the Nose (Kremen1) and Calbidin (Calb1) 6, we showed in mouse models that patch and matrix striatonigral neurons exert opposite influence on locomotion. While a reduction in neuronal activity in matrix striatonigral neurons precedes the cessation of locomotion, fiber photometry recording during self-paced movement revealed an unexpected increase of patch striatonigral neuron activity, indicating an inhibitory function. Indeed, optogenetic activation of patch striatonigral neurons suppressed locomotion, contrasting with the locomotion-promoting effect of matrix striatonigral neurons. Consistently, patch striatonigral neuron activation markedly inhibited dopamine release, whereas matrix striatonigral neuron activation initially promoted dopamine release. Moreover, the genetic deletion of inhibitory GABA-B receptor Gabbr1 in Aldehyde dehydrogenase 1A1-positive (ALDH1A1+) nigrostriatal dopaminergic neurons (DANs) completely abolished the locomotion-suppressing effect caused by activating patch striatonigral neurons. Together, our findings unravel a compartment-specific mechanism governing locomotion in the dorsal striatum, where patch striatonigral neurons suppress locomotion by inhibiting the activity of ALDH1A1+ nigrostriatal DANs.
Effects of Atorvastatin and Gemfibrozil on Mice Corpus Cavernosum, in vitro
Authors: erkoseoglu ilknur , Duman Mine Kadıoglu , Kesim Sabri , Yaris Ersin , Kalyoncu Nuri
Published: June 2024

Most of the drugs used in the treatment of cardiovascular diseases cause unfavourable effects on erectile functions. In this study, the effect of atorvastatin and gemfibrozil, which has different hypolipidemic mechanisms of action, on the erectile functions observed in mouse corpus cavernosum tissues are evaluatedin vitro. Mouse corpus cavernosum tissues are dissected under ketamine and xylazine anesthesia. Vessels were suspended in 30 ml organ baths filled with Krebs solution and aerated with carbogen (95% O2, 5% CO2) at 37°C. A initial tension of 500 mg was applied to the suspended tissue strips. After a stabilisation period of 90 minutes, the protocols were applied to the tissue. Atorvastatin and gemfibrozil showed no direct contractile or relaxant effect on corpus cavernosum tissues. Both drugs caused a dose –dependent relaxation in tissues precontracted with phenylephrine. While the relaxant effect of atorvastatin is inhibited 40% by L-NAME, this relaxations are totally inhibited by atropine. The relaxations caused by gemfibrozil are inhibited both by L-NAME and atropine. No change was observed in responses of the tissues to acethylcholine, nitroprusside and electrical field stimulation when incubated with atorvastatin or gemfibrozil. As a conlusion, both drugs showed similar effects on corpus cavernosum tissues. Atorvastatin and gemfibrozil caused these effects via endothelial nitric oxide. When all the results are evaluated, not only the two drugs showed no unfavorable effects but also may have some beneficial effects on erectile functions.