bluuebunny/crossref_metadata_2025 huggingface dataset:
Relativistic Effects for a Hydrogen Rydberg Atom in a High-Frequency Laser Field: Analytical Results
Authors: Kryukov Nikolay , Oks Eugene
Published: January 2022

Previously published analytical results for the effects of a high-frequency laser field on hydrogen Rydberg atoms demonstrated that the unperturbed elliptical orbit of the Rydberg electron, generally is engaged simultaneously in the precession of the orbital plane about the direction of the laser field and in the precession within the orbital plane. These results were obtained while disregarding relativistic effects. In the present paper, we analyze the relativistic effect for hydrogenic Rydberg atoms or ions in a high-frequency linearly- or circularly-polarized laser field, the effect being an additional precession of the electron orbit in its own plane. For the linearly-polarized laser field, the general case, where the electron orbit is not perpendicular to the direction of the laser field, we showed that the precession of the electron orbit within its plane can vanish at some critical polar angle θc of the orbital plane. We calculated analytically the dependence of the critical angle on the angular momentum of the electron and on the parameters of the laser field. Finally, for the particular situation, where the electron orbit is perpendicular to the direction of the laser field, we demonstrated that the relativistic precession and the precession due to the laser field occur in the opposite directions. As a result, the combined effect of these two kinds of the precession is smaller than the absolute value of each of them. We showed that by varying the ratio of the laser field strength F to the square of the laser field frequency ω, one can control the precession frequency of the electron orbit and even make the precession vanish, so that the elliptical orbit of the electron would become stationary. This is a counterintuitive result.
Simpson’s Second-Type Inequalities for Co-Ordinated Convex Functions and Applications for Cubature Formulas
Authors: Iftikhar Sabah , Erden Samet , Ali Muhammad Aamir , Baili Jamel , Ahmad Hijaz
Published: January 2022

Inequality theory has attracted considerable attention from scientists because it can be used in many fields. In particular, Hermite–Hadamard and Simpson inequalities based on convex functions have become a cornerstone in pure and applied mathematics. We deal with Simpson’s second-type inequalities based on coordinated convex functions in this work. In this paper, we first introduce Simpson’s second-type integral inequalities for two-variable functions whose second-order partial derivatives in modulus are convex on the coordinates. In addition, similar results are acquired by considering that powers of the absolute value of second-order partial derivatives of these two-variable functions are convex on the coordinates. Finally, some applications for Simpson’s 3/8 cubature formula are given.
Stability of Generalized Proportional Caputo Fractional Differential Equations by Lyapunov Functions
Authors: Agarwal Ravi , Hristova Snezhana , O’Regan Donal
Published: January 2022

In this paper, nonlinear nonautonomous equations with the generalized proportional Caputo fractional derivative (GPFD) are considered. Some stability properties are studied by the help of the Lyapunov functions and their GPFDs. A scalar nonlinear fractional differential equation with the GPFD is considered as a comparison equation, and some comparison results are proven. Sufficient conditions for stability and asymptotic stability were obtained. Examples illustrating the results and ideas in this paper are also provided.
Drug Delivery Based on Stimuli-Responsive Injectable Hydrogels for Breast Cancer Therapy: A Review
Authors: Xin Hai , Naficy Sina
Published: January 2022

Breast cancer is the most common and biggest health threat for women. There is an urgent need to develop novel breast cancer therapies to overcome the shortcomings of conventional surgery and chemotherapy, which include poor drug efficiency, damage to normal tissues, and increased side effects. Drug delivery systems based on injectable hydrogels have recently gained remarkable attention, as they offer encouraging solutions for localized, targeted, and controlled drug release to the tumor site. Such systems have great potential for improving drug efficiency and reducing the side effects caused by long-term exposure to chemotherapy. The present review aims to provide a critical analysis of the latest developments in the application of drug delivery systems using stimuli-responsive injectable hydrogels for breast cancer treatment. The focus is on discussing how such hydrogel systems enhance treatment efficacy and incorporate multiple breast cancer therapies into one system, in response to multiple stimuli, including temperature, pH, photo-, magnetic field, and glutathione. The present work also features a brief outline of the recent progress in the use of tough hydrogels. As the breast undergoes significant physical stress and movement during sporting and daily activities, it is important for drug delivery hydrogels to have sufficient mechanical toughness to maintain structural integrity for a desired period of time.
Synthesis and Characterization of Acrylamide/Acrylic Acid Co-Polymers and Glutaraldehyde Crosslinked pH-Sensitive Hydrogels
Authors: Khan Munir Ahmad , Azad Abul Kalam , Safdar Muhammad , Nawaz Asif , Akhlaq Muhammad , Paul Pijush , Hossain Md. Kamal , Rahman Md. Habibur , Baty Roua S. , El-kott Attalla F. , Kamel Mohamed , Bungau Simona G. , Abdel-Daim Mohamed M.
Published: January 2022

This project aims to synthesize and characterize the pH-sensitive controlled release of 5-fluorouracil (5-FU) loaded hydrogels (5-FULH) by polymerization of acrylamide (AM) and acrylic acid (AA) in the presence of glutaraldehyde (GA) as a crosslinker with ammonium persulphate as an initiator. The formulation’s code is named according to acrylamide (A1, A2, A3), acrylic acid (B1, B2, B3) and glutaraldehyde (C1, C2, C3). The optimized formulations were exposed to various physicochemical tests, namely swelling, diffusion, porosity, sol gel analysis, and attenuated total reflection-Fourier transform infrared (ATR-FTIR). These 5-FULH were subjected to kinetic models for drug release data. The 5-FU were shown to be soluble in distilled water and phosphate buffer media at pH 7.4, and sparingly soluble in an acidic media at pH 1.2. The ATR-FTIR data confirmed that the 5-FU have no interaction with other ingredients. The lowest dynamic (0.98 ± 0.04% to 1.90 ± 0.03%; 1.65 ± 0.01% to 6.88 ± 0.03%) and equilibrium swelling (1.85 ± 0.01% to 6.68 ± 0.03%; 10.12 ± 0.02% to 27.89 ± 0.03%) of formulations was observed at pH 1.2, whereas the higher dynamic (4.33 ± 0.04% to 10.21 ± 0.01%) and equilibrium swelling (22.25 ± 0.03% to 55.48 ± 0.04%) was recorded at pH 7.4. These findings clearly indicated that the synthesized 5-FULH have potential swelling characteristics in pH 6.8 that will enhance the drug’s release in the same pH medium. The porosity values of formulated 5-FULH range from 34% to 62% with different weight ratios of AM, AA, and GA. The gel fractions data showed variations ranging from 74 ± 0.4% (A1) to 94 ± 0.2% (B3). However, formulation A1 reported the highest 24 ± 0.1% and B3 the lowest 09 ± 0.3% sol fractions rate among the formulations. Around 20% drug release from the 5-FULH was found at 1 h in an acidic media (pH1.2), whereas >65% of drug release (pH7.4) was observed at around 25 h. These findings concluded that GA crosslinked 5-FU loaded AM and AA based hydrogels would be a potential pH-sensitive oral controlled colon drug delivery carrier.
Ingestion of Carbohydrate Solutions and Mouth Rinse on Mood and Perceptual Responses during Exercise in Triathletes
Authors: Martínez-Olcina María , Miralles-Amorós Laura , Asencio-Mas Nuria , Vicente-Martínez Manuel , Yáñez-Sepúlveda Rodrigo , Martínez-Rodríguez Alejandro
Published: January 2022

Triathlons are endurance events that include swimming, running, and cycling. Triathletes need to eat optimally during training and competitions to maximize their potential for success. The presence of carbohydrates in the mouth could activate regions in the brain to enhance athletic performance in exercise. Methods: This study examined the effects of glucose and mouthwash in ten male triathletes (age: 26.0 ± 8.7 years, height: 173.6 ± 10.4 cm, BMI 22.0 ± 1.7 kg/m2). The four oral test solutions included (A) Rinse with placebo, (B) Water + gel with placebo, (C) Rinse with 15% CH concentration, and (D) Water + gel with 15% CH concentration (25 g gel in 165 mL water). The Rate of Perceived Exertion (RPE), Sensation Scale (FS), Felt Arousal Scale (FAS), Profile of Mood States (POMS), blood glucose, sprints, and dietary habits were assessed in each subject. All preceded ingestion of the oral-based test solution during workouts. Results: RPE showed no significant differences for subjective perceptions. The same was observed for FS and sprints. FAS scores increased over time (p = 0.039) in all groups. POMS score increased significantly in group D (p = 0.041). There was no effect of time on plasma glucose levels (p = 0.737). As for correlations, positive correlations were observed between sprint and FAS variables (p = 0.011). Conclusions: It appears that CH intake correlates positively with mood, but in all other variables, there are no differences depending on the product.
Evaluation of a Semi-Airborne Electromagnetic Survey Based on a Multicopter Aircraft System
Authors: Kotowski Philipp O. , Becken Michael , Thiede Anneke , Schmidt Volkmar , Schmalzl Jörg , Ueding Stefan , Klingen Stefan
Published: January 2022

The semi-airborne electromagnetic (EM) method has the potential to reach deeper exploration depths than purely airborne EM approaches. The concept of the method is to deploy high-power transmitters on the ground, which excite subsurface currents and induce strong magnetic fields, and to measure the corresponding EM fields with a passive airborne receiver instrument. Following recent conceptual developments of the semi-airborne EM technique deployed on helicopters, we performed a 10 km2 semi-airborne EM survey near Münster (Germany) based on a multicopter aircraft system. For this purpose, horizontal electric dipole (HED) transmitters were installed in the survey area and were surveyed individually. Magnetic transfer functions were determined and a model of the conductivity of the study area was derived. Despite restrictions such as low payload capacity and multicopter-related EM noise, we were able to estimate spatially and spectrally consistent transfer functions of high quality up to a distance of 2 km from the respective transmitter. Our results could be validated with independent results from a magnetotelluric and a direct current sounding. The study demonstrates that an unmanned aircraft system (UAS) is suitable for semi-airborne EM application and that such a system can be beneficial where ground-based methods and manned techniques become impractical.
Adakites, High-Nb Basalts and Copper–Gold Deposits in Magmatic Arcs and Collisional Orogens: An Overview
Authors: Kepezhinskas Pavel , Berdnikov Nikolai , Kepezhinskas Nikita , Konovalova Natalia
Published: January 2022

Adakites are Y- and Yb-depleted, SiO2- and Sr-enriched rocks with elevated Sr/Y and La/Yb ratios originally thought to represent partial melts of subducted metabasalt, based on their association with the subduction of young (<25 Ma) and hot oceanic crust. Later, adakites were found in arc segments associated with oblique, slow and flat subduction, arc–transform intersections, collision zones and post-collisional extensional environments. New models of adakite petrogenesis include the melting of thickened and delaminated mafic lower crust, basalt underplating of the continental crust and high-pressure fractionation (amphibole ± garnet) of mantle-derived, hydrous mafic melts. In some cases, adakites are associated with Nb-enriched (10 ppm < Nb < 20 ppm) and high-Nb (Nb > 20 ppm) arc basalts in ancient and modern subduction zones (HNBs). Two types of HNBs are recognized on the basis of their geochemistry. Type I HNBs (Kamchatka, Honduras) share N-MORB-like isotopic and OIB-like trace element characteristics and most probably originate from adakite-contaminated mantle sources. Type II HNBs (Sulu arc, Jamaica) display high-field strength element enrichments in respect to island-arc basalts coupled with enriched, OIB-like isotopic signatures, suggesting derivation from asthenospheric mantle sources in arcs. Adakites and, to a lesser extent, HNBs are associated with Cu–Au porphyry and epithermal deposits in Cenozoic magmatic arcs (Kamchatka, Phlippines, Indonesia, Andean margin) and Paleozoic-Mesozoic (Central Asian and Tethyan) collisional orogens. This association is believed to be not just temporal and structural but also genetic due to the hydrous (common presence of amphibole and biotite), highly oxidized (>ΔFMQ > +2) and S-rich (anhydrite in modern Pinatubo and El Chichon adakite eruptions) nature of adakite magmas. Cretaceous adakites from the Stanovoy Suture Zone in Far East Russia contain Cu–Ag–Au and Cu–Zn–Mo–Ag alloys, native Au and Pt, cupriferous Ag in association witn barite and Ag-chloride. Stanovoy adakites also have systematically higher Au contents in comparison with volcanic arc magmas, suggesting that ore-forming hydrothermal fluids responsible for Cu–Au(Mo–Ag) porphyry and epithermal mineralization in upper crustal environments could have been exsolved from metal-saturated, H2O–S–Cl-rich adakite magmas. The interaction between depleted mantle peridotites and metal-rich adakites appears to be capable of producing (under a certain set of conditions) fertile sources for HNB melts connected with some epithermal Au (Porgera) and porphyry Cu–Au–Mo (Tibet, Iran) mineralized systems in modern and ancient subduction zones.
Long-Term Maintenance Strategies after Pulmonary Rehabilitation: Perspectives of People with Chronic Respiratory Diseases, Informal Carers, and Healthcare Professionals
Authors: Souto-Miranda Sara , Dias Cláudia , Jácome Cristina , Melo Elsa , Marques Alda
Published: January 2022

Pulmonary rehabilitation (PR) is an effective intervention for people with chronic respiratory diseases (CRD); however, its effects fade after 6–12 months. Community-based strategies might be valuable to sustain PR benefits, but this has been little explored. People with CRD, informal carers, and healthcare professionals (HCPs) were recruited from pulmonology appointments of two local hospitals, two primary care centres, and one community institutional practice and through snowballing technique. Focus groups were conducted using a semi-structured guide. Data were thematically analysed. Twenty-nine people with CRD (24% female, median 69 years), 5 informal carers (100% female, median 69 years), and 16 HCPs (75% female, median 36 years) were included. Three themes were identified: “Maintaining an independent and active lifestyle” which revealed common strategies adopted by people with “intrinsic motivation and professional and peer support” as key elements to maintain benefits, and that “access to information and partnerships with city councils’ physical activities” were necessary future steps to sustain active lifestyles. This study suggests that motivation, and professional and peer support are key elements to maintaining the benefits of PR in people with CRD, and that different physical activity options (independent or group activities) considering peoples’ preferences, should be available through partnerships with the community, namely city councils.
Participation in Sports Activities before and after the Outbreak of COVID-19: Analysis of Data from the 2020 Korea National Sports Participation Survey
Authors: Lee On , Park Soyoung , Kim Yeonsoo , So Wi-Young
Published: January 2022

The present study aimed to describe the characteristics and rate of participation in sports activities, changes in sports, and the causes of these changes before and after the COVID-19 out-break in Korea using data from the 2020 Korea National Sports Participation Survey (KNSPS). Furthermore, evidence from this study could be used as basic data to maintain and promote sports activities given the current situation, in which the continued spread of infectious diseases, such as COVID-19, is likely. The KNSPS is an annual survey of subjective health and fitness, sports activities and conditions, and participation in sports activities, conducted among a sample comprising the entire Korean population. The current study analyzed data for 9000 participants, and descriptive statistical analysis was performed to calculate the frequency of each item and sample weight. The rate of regular participation in sports activities at least once a week was found to be 60.10% in 2020, representing a decrease of 6.48% from the rate observed in 2019. Among the types of sports facilities frequently used within the residential area, the most common facilities were private sports facilities (22.97%), other sports facilities (20.60%), and public sports facilities (18.97%), although the utilization rate for other sports facilities increased after the COVID-19 outbreak. After the COVID-19 outbreak, 34.12% of men and 29.72% of women responded that there had been a change in their participation in regular sports activities. Both before and after the COVID-19 outbreak, walking was the most common activity, although the participation rate increased from 29.23% in 2019 to 35.70% in 2020. The rankings and participation rates for indoor sports activities (bodybuilding, swimming, etc.) tended to decrease, while those for outdoor sports activities (climbing, cycling, etc.) tended to increase. These changes may be explained in part by the increasing concern regarding infection with increasing age, except among teenagers, and by economic factors. While participation in physical activity provides numerous health benefits, the COVID-19 pandemic has had a negative impact on regular participation in sports activities. The results of this survey suggest that government action is required to enhance participation in sports activities, even in the face of a pandemic.
The Impact of the COVID-19 Pandemic on the Lifestyles and Levels of Anxiety and Depression of Patients with Schizophrenia: A Retrospective Observational Study
Authors: Biviá-Roig Gemma , Soldevila-Matías Pau , Haro Gonzalo , González-Ayuso Victor , Arnau Francisco , Peyró-Gregori Loreto , García-Garcés Laura , Sánchez-López Maria I. , Lisón Juan Francisco
Published: January 2022

The movement restrictions put in place as a result of the COVID-19 pandemic required modification of the population’s usual routines, including those of the most vulnerable groups such as patients with schizophrenia. This was a retrospective observational study. We used an online survey to collect information on patient adherence to the Mediterranean diet (Mediterranean Diet Adherence Screener questionnaire), physical exercise (International Physical Activity Questionnaire Short Form), and tobacco consumption and levels of anxiety and depression (Hospital Anxiety and Depression Scale) before and during the movement restrictions. A total of 102 people with schizophrenia participated in this study. During the COVID-19 pandemic lockdown the participants significantly increased the number of minutes spent sitting per day (z = −6.73; p < 0.001), decreased the time they spent walking (z = −6.32; p < 0.001), and increased their tobacco consumption (X2 = 156.90; p < 0.001). These results were also accompanied by a significant increase in their reported levels of anxiety (z = −7.45; p < 0.001) and depression (z = −7.03, p < 0.001). No significant differences in patient diets during the pandemic compared to before the movement restrictions were reported. These results suggest the need to implement specific programs to improve lifestyle and reduce anxiety and depression during possible future pandemic situations.
Differences in Menstruation-Related Symptoms of University Students Depending on Their Living Status in Japan
Authors: Matsuura Yukie , Tran Nam Hoang , Yasui Toshiyuki
Published: January 2022

Mothers and family members of young female students play important roles for guiding their self-care strategies for menstruation-related symptoms; which often affect their daily life and academic life. The aim of this study is to clarify the differences in menstruation-related symptoms before and during menstruation in university students living alone and university students living with their family in Japan. We conducted a cross-sectional online survey to assess menstruation-related symptoms before and during menstruation using the menstrual distress questionnaire (MDQ). Among 135 students; the proportion of students living alone was 60.7% and the proportion of students living with their family was 39.3%. Before menstruation; the MDQ total score and the scores for negative affect and behavior change were significantly higher in students living alone than in students living with their family. During menstruation; scores for negative affect and impaired concentration were also significantly higher in students living alone. In addition; before menstruation; scores for an increase in appetite and craving for sweets were significantly higher in students living alone. Thus; living alone affected the psychological aspects of menstruation-related symptoms in young women. The results suggest that university students who live alone should be aware of the importance of talking about their menstruation problems with family members and seeking their advice
An Efficient System for Eye Movement Desensitization and Reprocessing (EMDR) Therapy: A Pilot Study
Authors: Goga Nicolae , Boiangiu Costin-Anton , Vasilateanu Andrei , Popovici Alexandru-Filip , Drăgoi Marius-Valentin , Popovici Ramona , Gancea Ionatan Octavian , Pîrlog Mihail Cristian , Popa Ramona Cristina , Hadăr Anton
Published: January 2022

In this paper, we describe an actuator-based EMDR (eye movement desensitization and reprocessing) virtual assistant system that can be used for the treatment of participants with traumatic memories. EMDR is a psychological therapy designed to treat emotional distress caused by a traumatic event from the past, most frequently in post-traumatic stress disorder treatment. We implemented a system based on video, tactile, and audio actuators which includes an artificial intelligence chatbot, making the system capable of acting autonomously. We tested the system on a sample of 31 participants. Our results showed the efficiency of the EMDR virtual assistant system in reducing anxiety, distress, and negative cognitions and emotions associated with the traumatic memory. There are no such systems reported in the existing literature. Through the present research, we fill this gap by describing a system that can be used by patients with traumatic memories.
Alpha-Methyldopa May Attenuate Insulin Demand in Women with Gestational Diabetes Treated with Betamethasone
Authors: Kakoulidis Ioannis , Thomopoulos Costas , Ilias Ioannis , Stergiotis Stefanos , Togias Stefanos , Michou Aikaterini , Milionis Charalampos , Venaki Evangelia , Koukkou Eftychia
Published: January 2022

Gestational diabetes mellitus (GDM) is associated with hypertensive disorders in pregnancy. Alpha-methyl-DOPA (αMD) is a commonly used medication for hypertension in pregnant women. This medication may be associated with alteration in insulin resistance and glucose homeostasis. The aim of the present study was to investigate in 152 pregnant women whether the demands of exogenous insulin in glucocorticoid-treated women during pregnancy are different between those with GDM and hypertension treated with αMD and those without hypertension. In the group of women with GDM under insulin treatment, who received αMD for hypertension, the increase in insulin needs was relatively lower by at least 30% of the pre-admission insulin dose compared to all of the remaining women not receiving αMD in the same group (9 women vs. 50 women, p = 0.035). Our work raises the hypothesis that αMD can favorably modulate insulin sensitivity in the third trimester of pregnancy in previously insulin-treated women with gestational diabetes who receive glucocorticoids.
Householders Attitude, Preferences, and Willingness to Have Home Garden at Time of Pandemics
Authors: Basarir Aydin , Al Mansouri Noura M. N. , Ahmed Zienab F. R.
Published: January 2022

The value of home gardens has become more apparent among tenants forced into isolation in difficult and uncertain times arising since the COVID-19 pandemic started at the beginning of 2020. While gardens make a significant contribution to the social and ecological environment of cities, most studies have focused on public green spaces. Investigating householder preferences for gardens during and after the mandatory lockdown period in the UAE is required. The main objective of this study is to analyze the householder’s attitude, preferences, and willingness to have home gardens during the pandemic and after. The data were collected via an online survey of randomly selected respondents. A logistic econometrical model was utilized to analyze the factors affecting respondent preferences regarding having a garden. According to the results, the probability of having a garden increases among respondents who produce some crops, have attained Msc/PhD. level, a backyard, and a larger space to cultivate. It decreases among those who are married, find it hard to take care of a garden, and face a weed problem. In conclusions, it is highly recommended for householders to have home gardens, which can provide a quality lifestyle and enhance leisure time during the pandemic and after.
Physical Activity in High School Classrooms: A Promising Avenue for Future Research
Authors: Fenesi Barbara , Graham Jeffrey D. , Crichton Madeline , Ogrodnik Michelle , Skinner Jasmyn
Published: January 2022

Adolescence represents a sensitive period whereby lifestyle factors such as physical activity can have profound, long-lasting effects on development and later life habits. However, adolescence constitutes a period of frequent sedentary behaviour. Among children, integrating physical activity into elementary school classrooms has been shown to reduce sedentary behaviour and improve academic achievement and overall physical and mental health. However, this promising area of research has not extended to adolescents and high school classrooms. In this paper, we describe the benefits of conducting research on the impact of physically active high school classrooms, and highlight the challenges and potential misconceptions associated with research in this field. Specifically, we review research on the role of physical activity in adolescent development, the benefits of classroom-based physical activity for children, and discuss the factors that may have led researchers to focus on classroom-based physical activity primarily for children, despite the potentially similar benefits for adolescents.
Understanding the Spatiotemporal Variation of High-Efficiency Ride-Hailing Orders: A Case Study of Haikou, China
Authors: Du Mingyang , Li Xuefeng , Kwan Mei-Po , Yang Jingzong , Liu Qiyang
Published: January 2022

Understanding the spatiotemporal variation of high-efficiency ride-hailing orders (HROs) is helpful for transportation network companies (TNCs) to balance the income of drivers through reasonable order dispatch, and to alleviate the imbalance between supply and demand by improving the pricing mechanism, so as to promote the sustainable and healthy development of the ride-hailing industry and urban transportation. From the perspective of TNCs for order management, this study investigates the spatiotemporal variation of HROs and common ride-hailing orders (CROs) for ride-hailing services using the trip data of Didi Chuxing in Haikou, China. Ordinary least squares (OLS) and geographically weighted regression (GWR) models are established to examine the factors that affect the densities of HROs and CROs during different time periods, such as morning, evening, afternoon and night, with considering various built environment variables. The OLS models show that factors including road density, average travel time rate, companies and enterprises and transportation facilities have significant impacts on HROs and CROs for most periods. The results of the GWR models are consistent with the global regression results and show the local effects of the built environment on HROs and CROs in different regions.
Improving Road Surface Area Extraction via Semantic Segmentation with Conditional Generative Learning for Deep Inpainting Operations
Authors: Cira Calimanut-Ionut , Kada Martin , Manso-Callejo Miguel-Ángel , Alcarria Ramón , Bordel Sanchez Borja
Published: January 2022

The road surface area extraction task is generally carried out via semantic segmentation over remotely-sensed imagery. However, this supervised learning task is often costly as it requires remote sensing images labelled at the pixel level, and the results are not always satisfactory (presence of discontinuities, overlooked connection points, or isolated road segments). On the other hand, unsupervised learning does not require labelled data and can be employed for post-processing the geometries of geospatial objects extracted via semantic segmentation. In this work, we implement a conditional Generative Adversarial Network to reconstruct road geometries via deep inpainting procedures on a new dataset containing unlabelled road samples from challenging areas present in official cartographic support from Spain. The goal is to improve the initial road representations obtained with semantic segmentation models via generative learning. The performance of the model was evaluated on unseen data by conducting a metrical comparison where a maximum Intersection over Union (IoU) score improvement of 1.3% was observed when compared to the initial semantic segmentation result. Next, we evaluated the appropriateness of applying unsupervised generative learning using a qualitative perceptual validation to identify the strengths and weaknesses of the proposed method in very complex scenarios and gain a better intuition of the model’s behaviour when performing large-scale post-processing with generative learning and deep inpainting procedures and observed important improvements in the generated data.
End-to-End Pedestrian Trajectory Forecasting with Transformer Network
Authors: Yao Hai-Yan , Wan Wang-Gen , Li Xiang
Published: January 2022

Analysis of pedestrians’ motion is important to real-world applications in public scenes. Due to the complex temporal and spatial factors, trajectory prediction is a challenging task. With the development of attention mechanism recently, transformer network has been successfully applied in natural language processing, computer vision, and audio processing. We propose an end-to-end transformer network embedded with random deviation queries for pedestrian trajectory forecasting. The self-correcting scheme can enhance the robustness of the network. Moreover, we present a co-training strategy to improve the training effect. The whole scheme is trained collaboratively by the original loss and classification loss. Therefore, we also achieve more accurate prediction results. Experimental results on several datasets indicate the validity and robustness of the network. We achieve the best performance in individual forecasting and comparable results in social forecasting. Encouragingly, our approach achieves a new state of the art on the Hotel and Zara2 datasets compared with the social-based and individual-based approaches.
Drought Assessment Based on Fused Satellite and Station Precipitation Data: An Example from the Chengbi River Basin, China
Authors: Mo Chongxun , Meng Xuechen , Ruan Yuli , Wang Yafang , Lei Xingbi , Xing Zhenxiang , Lai Shufeng
Published: January 2022

Drought poses a significant constraint on economic development. Drought assessment using the standardized precipitation index (SPI) uses only precipitation data, eliminating other redundant and complex calculation processes. However, the sparse stations in southwest China and the lack of information on actual precipitation measurements make drought assessment highly dependent on satellite precipitation data whose accuracy cannot be guaranteed. Fortunately, the Chengbi River Basin in Baise City is rich in station precipitation data. In this paper, based on the evaluation of the accuracy of IMERG precipitation data, geographically weighted regression (GWR), geographic difference analysis (GDA), and cumulative distribution function (CDF) are used to fuse station precipitation data and IMERG precipitation data, and finally, the fused precipitation data with the highest accuracy are selected to evaluate the drought situation. The results indicate that the accuracy of IMERG precipitation data needs to be improved, and the quality of CDF-fused precipitation data is higher than the other two. The drought analysis indicated that the Chengbi River Basin is in a cyclical drought and flood situation, and from October to December 2014, the SPI was basically between +1 and −1, showing a spatial pattern of slight flooding, normal conditions, and slight drought.
Commonalities in the Features of Cancer and Chronic Fatigue Syndrome (CFS): Evidence for Stress-Induced Phenotype Instability?
Authors: Rusin Andrej , Seymour Colin , Cocchetto Alan , Mothersill Carmel
Published: January 2022

Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME) and Cancer-Related Fatigue (CRF) are syndromes with considerable overlap with respect to symptoms. There have been many studies that have compared the two conditions, and some of this research suggests that the etiologies of the conditions are linked in some cases. In this narrative review, CFS/ME and cancer are introduced, along with their known and putative mechanistic connections to multiple stressors including ionizing radiation. Next, we summarize findings from the literature that suggest the involvement of HPA-axis dysfunction, the serotonergic system, cytokines and inflammation, metabolic insufficiency and mitochondrial dysfunction, and genetic changes in CRF and CFS/ME. We further suspect that the manifestation of fatigue in both diseases and its causes could indicate that CRF and CFS/ME lie on a continuum of potential biological effects which occur in response to stress. The response to this stress likely varies depending on predisposing factors such as genetic background. Finally, future research ideas are suggested with a focus on determining if common biomarkers exist in CFS/ME patients and those afflicted with CRF. Both CFS/ME and CRF are relatively heterogenous syndromes, however, it is our hope that this review assists in future research attempting to elucidate the commonalities between CRF and CFS/ME.
Polymorphonuclear Neutrophils in Rheumatoid Arthritis and Systemic Lupus Erythematosus: More Complicated Than Anticipated
Authors: Haidar Ahmad Ahmad , Melbouci Dyhia , Decker Patrice
Published: January 2022

Polymorphonuclear neutrophils (PMN) are the most abundant leucocytes in the circulation in humans. They represent a heterogeneous population exerting diverse functions through several activities. Usually described as typical pro-inflammatory cells, immunomodulatory properties of PMNs have been reported. Among others, once activated and depending on the stimulus, PMNs expel neutrophil extracellular traps (NET) in the extracellular space. NETs are complexes made of DNA and granule proteins representing an innate immune mechanism fighting infections. Nevertheless, an excess of NET formation might be involved in the development of inflammatory or autoimmune responses. Systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) are two chronic, inflammatory, autoimmune diseases of unknown etiology and affecting mostly women. Several abnormal or non-classical functions of PMNs or PMN sub-populations have been described in SLE and RA. Particularly, NETs have been suggested to trigger pro-inflammatory responses by exposing pro-inflammatory mediators. Likewise, NETs may be the targets of autoantibodies or even might trigger the development of autoantibodies by exposing autoantigens. In the present review, we will summarize heterogeneous properties of human PMNs and we will discuss recent evidence linking PMNs and NETs to the pathogenesis of both SLE and RA.
News from the Cold Chamber: Clinical Experiences of POLARx versus Arctic Front Advance for Single-Shot Pulmonary Vein Isolation
Authors: Guckel Denise , Lucas Philipp , Isgandarova Khuraman , El Hamriti Mustapha , Bergau Leonard , Fink Thomas , Sciacca Vanessa , Imnadze Guram , Braun Martin , Khalaph Moneeb , Nölker Georg , Sommer Philipp , Sohns Christian
Published: January 2022

Cryoballoon (CB)-guided pulmonary vein isolation (PVI) represents a cornerstone in the treatment of atrial fibrillation (AF). Recently, a novel balloon-guided single shot device (POLARx, Boston Scientific) was designed. Our study aimed to compare the efficacy, safety and characteristics of the novel CB system with the established one (Arctic Front Advance (Pro), AFA, Medtronic). A total number of 596 patients undergoing CB-guided ablation for AF were included. 65 patients (65.0 ± 11.6, 31% female) undergoing PVI with the POLARx were compared to a cohort of 531 consecutive patients (63.0 ± 27.9, 25% female) treated with AFA. Acute PVI was achieved in all patients (n = 596, 100%). Total procedure duration (POLARx 113.3 ± 23.2 min, AFA 100.9 ± 21.3 min; p < 0.001) and fluoroscopy time (POLARx 10.5 ± 5.9 min, AFA 4.8 ± 3.6 min; p < 0.001) were significantly longer in the POLARx group. The POLARx balloon achieved significantly lower nadir temperatures (POLARx −57.7 ± 0.9 °C, AFA −45.1 ± 2.6 °C; p < 0.001) and a significantly higher percentage of pulmonary veins successfully isolated with the first freeze (p = 0.027 *). One major complication occurred in the POLARx (2%) and three (1%) in the AFA group. Both ablation systems are comparably safe and effective. AF ablation utilizing the POLARx system is associated with longer procedure and fluoroscopy times as well as lower nadir temperatures.
Eradication of Ventricular Assist Device Driveline Infection in Paediatric Patients with Taurolidine
Authors: Weichsel Johannes , Baldauf Benito , Bonnemeier Hendrik , Lau Ernest W. , Dittrich Sven , Cesnjevar Robert
Published: January 2022

Ventricular assist devices (VADs) are used to provide mechanical circulatory support to patients with end-stage heart failure. The driveline connecting the external power source to the pump(s) of the intra-corporal VAD breaches the protective skin barrier and provides a track for microbes to invade the interior of the patient’s body. Driveline infection constitutes a major and potentially fatal vulnerability of VAD therapy. Driveline infection cannot traditionally be salvaged and requires the extraction of the entire VAD system. We report here the successful eradication of a VAD driveline infection with a taurolidine-containing antimicrobial solution used for preventing the infection of cardiac implantable electronic devices. If replicated in more cases, the novel treatment concept described here may provide a valuable alternative management strategy of salvage rather than explantation for VAD driveline infection.
Intraperitoneal Triamcinolone Reduces Postoperative Adhesions, Possibly through Alteration of Mitochondrial Function
Authors: Purandare Neeraja , Kramer Katherine J. , Minchella Paige , Ottum Sarah , Walker Christopher , Rausch Jessica , Chao Conrad R. , Grossman Lawrence I. , Aras Siddhesh , Recanati Maurice-Andre
Published: January 2022

Adhesions frequently occur postoperatively, causing morbidity. In this noninterventional observational cohort study, we enrolled patients who presented for repeat abdominal surgery, after a history of previous abdominal myomectomy, from March 1998 to June 20210 at St. Vincent’s Catholic Medical Centers. The primary outcome of this pilot study was to compare adhesion rates, extent, and severity in patients who were treated with intraperitoneal triamcinolone acetonide during the initial abdominal myomectomy (n = 31) with those who did not receive any antiadhesion interventions (n = 21), as documented on retrospective chart review. Adhesions were blindly scored using a standard scoring system. About 32% of patients were found to have adhesions in the triamcinolone group compared to 71% in the untreated group (p < 0.01). Compared to controls, adhesions were significantly less in number (0.71 vs. 2.09, p < 0.005), severity (0.54 vs. 1.38, p < 0.004), and extent (0.45 vs. 1.28, p < 0.003). To understand the molecular mechanisms, human fibroblasts were incubated in hypoxic conditions and treated with triamcinolone or vehicle. In vitro studies showed that triamcinolone directly prevents the surge of reactive oxygen species triggered by 2% hypoxia and prevents the increase in TGF-β1 that leads to the irreversible conversion of fibroblasts to an adhesion phenotype. Triamcinolone prevents the increase in reactive oxygen species through alterations in mitochondrial function that are HIF-1α-independent. Controlling mitochondrial function may thus allow for adhesion-free surgery and reduced postoperative complications.
A Real-World Comparative Study of Microwave and Radiofrequency Ablation in Treatment-Naïve and Recurrent Hepatocellular Carcinoma
Authors: Lee Soon Kyu , Chung Dong Jin , Cho Se Hyun
Published: January 2022

The efficacy and safety of microwave ablation (MWA) compared to radiofrequency ablation (RFA) for patients with treatment-naïve and recurrent hepatocellular carcinoma (HCC) has not been clarified in Korea. There were 150 HCC patients (100 in the RFA group and 50 in the MWA group) enrolled in our study. The primary outcome was one- and two-year disease-free survival (DFS). Secondary outcomes were complete response (CR) rate, two-year survival rate, risk factors for DFS and complication rate. Treatment outcomes were also assessed using propensity-score matching (PSM). The MWA group had better one- and two-year DFS than the RFA group (p = 0.035 and p = 0.032, respectively), whereas the CR rate, two-year survival rate, and complication rate were similar between the two groups with fewer major complications in the MWA group (p = 0.043). Patients with perivascular tumors, high risk of recurrence, and small tumor size (≤3 cm) were more suitable for MWA than RFA. MWA was also an independent factor for favorable one- and two-year DFS. Finally, the MWA group still showed better one- and two-year DFS than the RFA group after PSM. In conclusion, MWA could be an alternative treatment to RFA especially in patients with a high risk of recurrence, perivascular tumors, and small tumor size.
Positive Airway Pressure at Extubation Minimizes Subglottic Secretion Leak In Vitro
Authors: Wang Tzu-Pei , Li Hsin-Hsien , Lin Hui-Ling
Published: January 2022

Accumulated secretion above the endotracheal tube cuff can be aspirated during extubation after deflation. The possible techniques for minimizing pulmonary aspiration from subglottic secretion during extubation have not been well explored. This study aimed to determine the effect of different extubation techniques on secretion leakage. An endotracheal tube was placed in a tube mimicking an airway. We measured the leak volume of water or artificial sputum of different viscosities with three extubation techniques—negative pressure with suctioning; positive pressure with a resuscitator; and continuous positive airway pressure set at 5, 10, and 20 cm H2O. Extubation with continuous positive airway pressure resulted in lower secretion leakage than that with negative pressure with suctioning and positive pressure with a resuscitator. Increasing the continuous positive airway pressure level decreased secretion leakage volume during extubation. We further determined a correlation of leak volume with sputum viscosity. Continuous positive airway pressure at 5 cm H2O produced lower volume secretion leakage than the other two techniques, even with higher secretion viscosity. Based on these results, using continuous positive airway pressure with a previous ventilator continuous positive airway pressure/positive end-expiratory pressure setting for extubation is recommended.
Liver Injury in Patients with COVID-19 without Underlying Liver Disease
Authors: Pazgan-Simon Monika , Serafińska Sylwia , Kukla Michał , Kucharska Marta , Zuwała-Jagiełło Jolanta , Buczyńska Iwona , Zielińska Kamila , Simon Krzysztof
Published: January 2022

SARS-CoV-2 shows a high affinity for the ACE-2 receptor, present on the epithelial cells of the upper and lower respiratory tract, within the intestine, kidneys, heart, testes, biliary epithelium, and—where it is particularly challenging—on vascular endothelial cells. Liver involvement is a rare manifestation of COVID-19. Material and Methods: We reviewed 450 patients admitted due to the fact of SARS-CoV-2 infection (COVID-19) including 88 with liver injury. Based on medical history and previous laboratory test results, we excluded cases of underlying liver disease. The analysis involved a clinical course of COVID-19 in patients without underlying liver disease as well as the type and course of liver injury. Results: Signs and symptoms of liver injury were present in 20% of patients, mostly presenting as a mixed-type pattern of injury with less common cases of standalone hepatocellular (parenchymal) or cholestatic injury. The liver injury symptoms resolved at the end of inpatient treatment in 20% of cases. Sixteen patients died with no cases where liver injury would be deemed a cause of death. Conclusions: (1) Liver injury secondary to COVID-19 was mild, and in in 20%, the signs and symptoms of liver injury resolved by the end of hospitalization. (2) It seems that liver injury in patients with COVID-19 was not associated with a higher risk of mortality. (3) The underlying mechanism of liver injury as well as its sequelae are not fully known. Therefore, caution and further monitoring are advised, especially in patients whose liver function tests have not returned to normal values.
Factors Predicting Response to Selective Retina Therapy in Patients with Chronic Central Serous Chorioretinopathy
Authors: Kim Minhee , Jeon Seung Hee , Lee Ji-young , Lee Seung-hoon , Roh Young-jung
Published: January 2022

This retrospective study aimed to assess the safety and efficacy of selective retina therapy (SRT) with real-time feedback-controlled dosimetry (RFD) for chronic central serous chorioretinopathy (CSC) and to evaluate factors predictive of treatment response. We included 137 eyes of 135 patients with chronic CSC. SRT was performed to cover each of the leakage areas on fundus fluorescein angiography. Changes in mean best-corrected visual acuity (BCVA), central macular thickness (CMT), and subretinal fluid (SRF) height were evaluated at baseline and at 3 and 6 months after treatment. Complete SRF resolution was observed in 52.6% (72/137 eyes) and 90.5% (124/137 eyes) at 3 and 6 months, respectively. Mean BCVA (logMAR) significantly improved from 0.41 ± 0.31 at baseline to 0.33 ± 0.31 at month 6 (p < 0.001). Mean CMT significantly decreased from 347.67 ± 97.38 μm at baseline to 173.42 ± 30.95 μm at month 6 (p < 0.001). Mean SRF height significantly decreased from 187.85 ± 97.56 µm at baseline to 8.60 ± 31.29 µm after 6 months (p < 0.001). Baseline SRF height was a significant predictive factor for retreatment requirement (p = 0.008). In conclusion, SRT showed favorable anatomical outcomes in patients with chronic CSC. A higher baseline SRF height was a risk factor for retreatment.