bluuebunny/crossref_metadata_2025 huggingface dataset:
Removal of Dyes from Wastewater by Ceramic Membrane
Authors: Al-Alawy Ramy Mohamed Jebir , Abod Baker M. , Kamar Firas Hashim , Nechifor Aurelia Cristina
Published: January 2020

The current study aimed to investigate the elimination of dyes from sewerage, using microfiltration membrane mechanism. Three dyes were applied, acid yellow-23, disperse blue -79 and acid orange -7. Experiments were performed with feed concentration (40 -120) ppm, feed flow rate (25 -65) l/h and time (0.25 -1.5) h. The membrane used ceramic membrane, constructed as a candle. It was discovered that water flow diminishes with an elevation in running time, feeding oil concentration and enhancing with elevation in the feed flow rate. In addition, it was determined that the elimination (rejection) rate of dyes enhances with elevation in the flow rate, and the elimination (rejection) rate diminishes as time passes. In cross flow microfiltration, the rejection concentration (concentrate) goes up as time passes, with high feed concentration and flow rate. It was also discovered that the modal infusion concentration declines with high feed concentration and working time. In addition, it was found that product rate goes down as time passes and with high feed concentration. Increasing feed concentration of dyes was associated with an increase in the concentration of rejecting solution. The highest elimination of disperse blue -79, Acid Yellow- 23 and acid orange -7, are 97%, 96.4% and 95.8%, respectively. The maximum recovery percentage of disperse blue - 79, acid yellow- 23 and acid orange -7are 57.7%, 58.5% and 59% respectively.
The Predictive Role of Biochemical Plasma Factors in Patients with Severe Traumatic Brain Injuries
Authors: Papacocea Marius Toma , Badarau Ioana Anca , Radoi Mugurel , Papacocea Ioana Raluca
Published: January 2020

Traumatic brain injuries (TBI) represent a high impact public health problem due to a high rate of death , long term disability and occurrence especially in young adults. Despite several promising animal studies, several parameters were proposed as biological markers and were assessed for this aim. Our study proposes the study of the early biochemical changes in association to hematological parameters for severe TBI patients prognosis. 43 patients with acute TBI were included in study based on clinical, laboratory and imagistic findings. The severity of the TBI was established by Glasgow Coma Scale GCS 3-8. In all patients were evaluated hematologic parameters (Red blood cell count - RBC, Hematocrit, blood Hemoglobin, White blood cell - WBC, Platelet count and biochemical parameters (glucose, urea, creatinine, electrolytes). Outcome was expressed as Glasgow Outcome Scale (GOS), between 1-5. Values were compared to control group -15 cases. Significant early differences in body temperature, heart rate, and systolic blood pressure were observed in TBI group versus control (p[0.05). After correlation, laboratory findings significantly associated to severe outcome - GOS = 1, 2 - (p[0.05) were plasma Na decrease and significant glucose increase. An early increase of temperature and decrease of Na may predict a severe outcome in patients with acute TBI; association with shifts in heart rate and blood pressure, imposes aggressive treatment measures.
Clinical and Biochemical Correlations Obesity - HDL Cholesterol- Ischemic Coronary Heart Disease
Authors: Mavritsakis Nikolaos , Cotoi Bogdan Virgil , Ganescu Anca , Ionescu Elena
Published: January 2020

Central obesity is defined by increasing abdominal circumference ranging from certain limits to the characteristics of the ethnic groups of the rated person (] 94 cm for European males and] 80 cm for Euclid women). The metabolic syndrome, commonly associated with central obesity, must meet at least two of the following four criteria:increased triglyceride levels] 159 mg / dL or specific treatment for this type of dyslipidemia; Low HDL-cholesterol [40 mg / dL or specific treatment for this type of dyslipidemia;Increased blood pressure: Systolic BP �130 mm Hg or Diastolic BP �85 mm Hg, or HTA treatment previously diagnosed;
High blood glucose level �100 mg / dL or type 2 diabetes diagnosed previously. HDL-cholesterol (HDL-C) is a group of lipoproteinssynthesized and secreted by hepatocytes. HDL plays an important role in the metabolism of cholesterol, participating in its transport from extrahepatic tissues to the liver for catabolism and excretion.. HDL and LDL participate in maintaining cell cholesterol levels. HDL-cholesterol and apolipoprotein-A values are positive atherosclerosis risk factors. The high level of HDL-C protects the patient, with a low risk of atherosclerosis HDL dosing is done for assessing the risk of coronary artery disease; diagnosis of hyperlipoproteinemia. Increased body weight is associated with increased total mortality and morbidity due to cardiovascular disease, partly mediated by increased blood pressure and cholesterol, lowering HDL-cholesterol and increasing the likelihood of diabetes.
Study of Phenolic Compounds and Antimicrobial Activity of Lavandula angustifolia L. Flowers Macerates
Authors: Stanciu Gabriela , Aonofriesei Florin , Lupsor Simona , Popescu Antoanela , Sirbu Rodica
Published: January 2020

Studies of total phenolic content and identification and quantification of phenolic compounds by HPLC-DAD from hydro-alcoholic and alcoholic macerates of Lavandula angustifolia L flowers from Dobrogea area are reported. The total phenolic content and the phenolic profile have been measured using Folin-Ciocalteau method, respectively adapted USP30 HPLC method in macerates of Lavandula angustifolia L flowers after 5 days of contact with either methanol (M1) or methanol: water 1 : 1 (V : V) mixture (M2). The values of TPC show that macerate M2 is more rich in phenolic compounds (3520 mg/100g d.w.), than in the case of macerate M1 (2860 mg/100 g d.w.). The obtained data of phenolic compounds determined by HPLC-DAD method were compared with the available authentic standards. Four individual phenolic compounds were found in macerate M1 and six individual phenolic compounds in macerate M2. Among gallic acid and chlorogenic acid, as major phenolic compounds, high concentrations of ellagic acid in M2 (514.249 mg/100 g d.w.) and M1 (499.487 mg/100g d.w.) were found. The antimicrobial activity of tested macerates indicates that Lavandula sp. has a moderate effect on the bacterial and Candida growth.
Dangerous Chemical Agents: General and Odonto-Stomatological Aspects with Importance in Forensic Toxicology
Authors: Iov Tatiana , Costescu Mihnea , Diac Madalina , Tabian Daniel , David Sofia Mihaela , Knieling Anton , Damian Simona Irina
Published: January 2020

In the heavy and light industry, the food and pharmaceutical industry, there are chemicals that contain metals with high toxic potential. Toxicity of metals is due to the harmful effect in certain forms and doses. Some metals become toxic when they form soluble compounds or in a certain chemical structure at certain doses (eg lead, mercury and candium). Not only heavy metals are toxic metals, there are also light metals that can become toxic, some of which are essential elements (iron, selenium, copper, chromium, zinc) and metals used therapeutically in medicine (aluminum, bismuth, gold, gallium, lithium and silver) may have negative effects when administered in large quantities or the elimination from the human body is deficient. Metal poisoning occurs through nutrition, medication, environmental factors. Most professional pollutants with intraoral manifestations appear in the heavy industry. The oral cavity is an entry gate for various toxic pathogens, so intoxications can be detected early due to the manifestations inside the mouth.
Chemical Characterization of Artemisia Annua L. Extract Assessment of Antioxidant Activity in vitro and in vivo Toxicity Studies
Authors: Stan Roxana Liana , Sevastre Bogdan , Hangan Adriana Corina , Bota Sanda , Hanganu Daniela , Ionescu Corina Maria Lucia , Popovici Cristian , Sevastre-Berghian Alexandra Cristina , Dreanca Alexandra , Vicas Laura Gratiela
Published: January 2020

The purpose of the study was to demonstrate in vitro antioxidant activity and in vivo toxicity of the Artemisia Annua L. extract. The plant was harvested from Bihor area (Crisul Repede and Negru river valleys), Romania. Preparation of the plant product and of the lyophilizated extract was carried out in accordance with the Romanian Pharmacopeia Xth Edition. Lyophilized extract was evaluated in terms of polyphenol content using HPLC method. Antioxidant activity was highlighted using the DPPH, ABTS and FRAP methods. Hepatic, renal and haematological toxicity studies have been performed on laboratory mice. For this purpose blood and organs were collected. Biochemical and haematological parameters were determined on the blood samples and histopathological examination was performed on organs. In vitro antioxidant effect of Artemisia Annua L extract and its lack of in vivo toxicity were demonstrated. It is desirable to obtain a new phytoproduct harvested from spontaneous flora of Romania with antioxidant / antitumoral properties and which is devoid of toxicity.
Analytical Semi-Empirical Model for the Prediction of Products Yields at the Fast Pyrolysis of Waste Palm Oil
Authors: Sivriu Ana Maria , Tarpan Doinita Roxana , Koncsag Claudia-Irina , Mares Alina Monica , Jinescu Cosmin
Published: January 2020

The interest for vegetable oils, as a source of fuels and chemicals, boosted in the last two decades amid concerns related to oil depletion. The fast pyrolysis is a process of industrial consequences. In the present study, original experimental data in fast pyrolysis are processed in order to find the parameters of ASEM- an analytical semi-empirical model developed by the Clean Combustion Technology Laboratory (CCTL), University of Florida. The parameters, constants and coefficients of the model equation (w, To, D, p and q), were calculated for each main product with satisfactory accuracy and results were compared with other authors�. The results were discussed based on similarities and differences between slow and fast pyrolysis. The conclusion was that ASEM is a valid model which can be applied with confidence in very different process conditions.
Hydrogen Peroxide and Peracetic Acid Oxidizing Potential in the Treatment of Water
Authors: Popescu Elena Madalina , Pantea Octav , Gologan Daniela , Doukeh Rami
Published: January 2020

Mixture based on peracetic acid and hydrogen peroxide is a more powerful oxidant than chlorine and chlorine dioxide. The reactivity of this oxidizing mixture with the polluting substances in the water: ammonium compounds, nitrites, iron, manganese, organic proteins is evaluated in this study. The results obtained after tasting this mixture, using various natural groundwater matrices shows an oxidation efficiency of over 90% of ammonium and nitrite content, between 40-70% of iron and 25-50% for manganese forms. The advantage of this oxidation mixture compared to thechlorine substances is that they do not form threehalomethane byproducts that have carcinogenic effect.
The Effect of Antidepressant Chemical Compounds on Masticatory Muscles Activity in Depressive Patients Electromyographic study
Authors: Albert Elena Luminita , Sabau Daniela Claudia , Grecu Cristian Gabos , Vaida Ligia , Todor Ioana , Josan lucian , Pacurar Mariana
Published: January 2020

Using the surface electromyography, we evaluated the effect of long- term intake of antidepressant chemical compounds on the masticatory muscles electrical activity at rest in twenty-one subjects. We compared the patient�s acquired data from the masseter and temporalis muscles with the default values for the resting activity of these muscles. We found significantly higher mean rest values concerning the amplitude of signals in all sites (p[0.05), except the left masseter. Considering the limits of the study, it appears that long-term treatment that uses chemically compounds with antidepressant effect may influence the masticatory muscles activity, manifested by hypertonicity at rest.
Assessment of Pain During Laser-based Procedures in the Treatment of Glaucoma
Authors: Popa Gheorghita , Karancsi Olimpiu L. , Preda Maria Alexandra , Suta Marius Cristian , Stelea Lavinia , Musat Ovidiu , Popescu Stella Ioana , Balica Nicolae Constantin , Bogdanici Camelia , Munteanu Mihnea
Published: January 2020

Our study aimed to determine pain levels and the state of welfare connected to laser-based procedures in the treatment of patients diagnosed with uncontrolled glaucoma. The study group included 100 eyes of 100 patients diagnosed with glucoma, 50 of them being treated with micropulse transscleral laser cyclophotocoagulation, and the other 50 eyes being treated with continuous transscleral laser cyclophotocoagulation. We used visual analog scale to gather information from each patient. After analysing the individual information the following results were obtained: the pain level for the micropulse transscleral laser cyclophotocoagulation was 60.23 mm, signifying moderate pain; and the pain score for the continuous transscleral laser cyclophotocoagulation was 76.34 mm, corresponding to moderate-intense pain. Pain level generated by minimally invasive laser procedures is discussed.
Characterization of Bioactive Compounds from Romanian Cetraria islandica (L) Ach
Authors: Patriche Simona , Ghinea Ioana Otilia , Adam Gigi , Gurau Gabriela , Furdui Bianca , Dinica Rodica Mihaela , Rebegea Laura-Florentina , Lupoae Mariana
Published: January 2020

Lichens (Lichenophyta phylum), the least exploited subdivision of fungus, are composite plants used in folk medicine for the treatment of diverse pathologies, from respiratory to digestive diseases, as they contain over 500 potentially bioactive compounds identified up-to-date. Lichen acids, such as usnic acid, lobar acid, lecanoric acid or salazinic acid, are among these compounds, with biopharmaceutical applications as antimicrobial, antioxidant and cytotoxic agents. The objectives of this study were to extract usnic acid from Romanian Cetraria islandica, (Parmeliaceae family), to characterize the extracts and to evaluate their antioxidant and antimicrobial potential. The extracts were characterized using FTIR spectroscopy and HPTLC techniques. The extracts and pure usnic acid have shown high antioxidant activity and have activity against certain Gram-positive and Gram-negative bacteria and fungi such as Candida albicans. Therefore, the analyzed bioactive compounds could be used as the basis of pharmaceutical formulations to treat various respiratory and digestive disorders.
WATERSHED - Android Application for the Mineral Waters Classification
Authors: Misaila Lavinia , Nedeff Florin Marian , Barsan Narcis , Sandu Ioan Gabriel , Grosu Luminita , Patriciu Oana-Irina , Gavrila Lucian , Finaru Adriana-Luminita
Published: January 2020

Water classification based on mineral content is useful to determine the curative properties of each type. The water type is determined accordingly the parameter followed, like as: physical, chemical, microbiological, pharmacological, physiological and clinic. This paper presents a study of the main types of mineral waters based on specific criteria of classification applied to the mineral water springs found in the treatment resort, Slanic-Moldova. The concept of Stuyfzand�s water classification was applied to build an Android application � named Watershed, using a block-based encryption program, MIT App Inventor. This program classifies the mineral water source by chemical composition and its location on the map using the Google Maps mapping system. By synchronization with the Google Maps online service, a map of mineral water springs at source as well as a capture can be created.
Correlations Between Distinct Ras Mutations and Response to Bevacizumab in Patients with Colo-rectal Cancer
Authors: Ghimpau Valentina , Lungulescu Cristina , Grecu Alexandru Florian , Gheonea Dan Ionut , Danciulescu Mihaela , Gheorman Victor , Gheorman Veronica , Volovat Simona Ruxandra , Lungulescu Cristian Virgil
Published: January 2020

CRC is currently ranked third among frequently diagnosed malignancies. Mutations in exons 2,3 and 4 of the KRAS and NRAS genes were detected using a targeted resequencingassay from paraffin embedded tissue from patients� biopsies samples. The following data was recorded for each patient: baseline information - age and sex � as well as diagnosis, cancer localization, disease stage and laboratory parameters.In our study group we could not find statistically significant differences regarding distinct mutations and the progression free survival (p=0.34]0.05) for patients treated with an anti-angiogenic therapy.
X-ray Diffraction and Spectral Investigation of the Consequences of Obtaining Impurities from a Material of a Reactor to Obtain the Titanium Sponge
Authors: Chervonyj Ivan , Listopad Dmytro , Shakhnin Dimitrii , Malyshev Victor , Donath Cristina , Neacsu Elena Ionela , Constantin Virgil , Popescu Ana-Maria
Published: January 2020

Impurity level in a titanium sponge is essential for a pure titanium production. Using X-ray diffraction and spectral microanalysis the qualitative character of element distribution from a deep surface into different samples from the reactor was studied. Studying microphotographs of micro-sections of samples it was also identified the definition processes proceeding with a material of a reactor during titanium operation.
Estimating Ternary Blends Properties using ANNs Trained with Binary Blends
Authors: Sandru Stefan , Onutu Ion
Published: January 2020

The present study aimed to estimate the physical properties of the diesel-diesel-biodiesel ternary blends, using artificial neural networks, also known as ANNs. The input data used to estimate the properties was the percentage in which each component was used to obtain the blend. Using two hydrofined diesel fuels from a local refinery and three biodiesel samples synthesized in the university laboratory, a total of 114 blends, both binary and ternary, were obtained. The ANN training database was comprised of exclusively 96 binary blends, from the total of 114. The predictions were made on the remaining 18 ternary blends. All the predictions were within the error mentioned in the standard, concluding the fact that the created ANNs had a rate of 100% accuracy.
Critical Stresses in Materials with Cracks
Authors: Manea Simona Eugenia , Nicolof Vali Ifigenia , Sima Teodor
Published: January 2020

The fracture mechanics concepts, as well as the concepts introduced on the basis of principle of critical energy, correlated with strength of materials with cracks is analysed. The equivalent stress method of strength was applied to cracked materials, by using the concept of local critical stress. This one depends on the material behavior and the deterioration due to crack. Experimental results have been obtained with specimens of OL304 steel with different cracks. The influence of crack depth and crack width is put into evidence.
Comparative Study Between two Reaction Kinetic Mechanisms of Thiophene Hydrodesulphurization over CoMo /gama - Al2O3 Supported Catalyst
Authors: Doukeh Rami , Bombos Mihaela , Bolocan Ion
Published: January 2020

The kinetic study of the thiophene hydrodesulphurisation process was carried out for CoMo/gama-Al2O3 catalyst, at temperatures between 175 and 275 �C, pressure ranged from 30bar to 60 bar and the liquid hourly space velocity from 1h-1 to 4 h-1. For the reaction mechanism, the Langmuir-Hinshelwood-Hougen-Watson model (LHHW) was used and two kinetic models were proposed: the first model, that considered that H2 is adsorbed on a different type of active center than thiophene and the second model, that considered that the two reactants are adsorbed on the same type of active sites. The values obtained for the average relative error (ARE) and the correlation coefficient between the experimental and the calculated data (R2) indicate that the Langmuir-Hinshelwood model, describing the adsorption on two active sites, best describes the kinetics of the thiophene hydrodesulfurization reaction over CoMo/gama-Al2O3 tested catalyst.
The Comparative Study of Equisetum pratense, E. sylvaticum, E. telmateia: Accumulation of Silicon, Antioxidant and Antimicrobial Screening
Authors: Marin Denisa Batir , Cioanca Oana , Apostu Mihai , Tuchilus Cristina Gabriela , Mircea Cornelia , Robu Silvia , Tutunaru Dana , Corciova Andreia , Hancianu Monica
Published: January 2020

The objective of the current study is represented by the determination of silica and a phytochemical screening of phenolic derivates of some Equisetum species. The antioxidant and antimicrobial activity for Equisetum pratense Ehrh.,, Equisetum sylvaticum L. and Equisetum telmateia Ehrh. (sin. Equisetum maximum Lam.) were also investigated. The concentration of silicon (Si) in plants was determined by the spectrophotometric method using previous treatment with NaOH 50% both for the stem and the nodal branches [1]. Results obtained varied from 95.12 to 162.10 SiO2 mg/g dry plant which represents 4.44% to 7.58% Si/100g dry sample. Two types of total extracts were obtained using different solvents and were subjected to qualitative and quantitative chemical analysis considering total phenolic content [2]. The highest concentration of investigated compounds was found in the methanolic extract, E. sylvaticum, 196.5mg/g dry sample. Antioxidant activity was monitored spectrophotometrically and expressed in terms of IC50 (�g/mL) [3]. Values gathered ranged from 261.7 to 429.5 �g/mL. The highest capacity to neutralized DPPH radicals was found in E. sylvaticum. In vitro antimicrobial activity was determined using difusimetric method [4]. Testing was performed on four microorganisms: three strains of bacteria and one species of fungi. Different effects were noticed against the bacteria, furthermore the methanol extract appeared to be most efficient. All extracts showed significand antimicrobial activity against Staphylococcus aureus (ATCC 25923) and Candida albicans (ATCC 90028) and weak to no activity against Pseudomonas aeruginosa (ATCC 27853) and Escherichia coli (ATCC 25922).
Study of Physico-chemical Characteristics and Pharmacological Effects of 1-Ethyl-Salicyldene-bis-Ethylene-Diamine and Its Complex with Mn(II)
Authors: Tantaru Gladiola , Apostu Mihai , Poiata Antonia , Nichifor Mihai , Bibire Nela , Panainte Alina Diana , Vieriu Madalina
Published: January 2020

The paper presents the synthesis of a new complex combination of a Bis-Schiff base with Mn(II) ions with great potential for antimicrobial and anti-inflammatory activity. A new complex of the Salen-type ligand, 1-ethyl-salicylidene-bis-ethylene diamine was synthetized using Mn(II) ions. The chemical structure was confirmed through 1H-NMR and IR spectroscopy. The antimicrobial activities of the Bis-Schiff base and its complex were tested in comparison with Ampicillin, Chloramphenicol, Tetracycline, Ofloxacin and Nystatin. Those compounds were found to be active against Gram-positive or Gram-negative bacteria, and had an anti-inflammatory effect comparable to that of Indomethacin.
Compatibility Studies of Valsartan with Different Pharmaceutical Excipients
Authors: Tita Ioana Cristina , Lupa Lavinia , Tita Bogdan , Stan Roxana Liana , Vicas Laura
Published: January 2020

Compatibility studies between active drugs and excipients are substantial in the pharmaceutical technology. Thermal analysis has been extensively used to obtain information about drug-excipient interactions and to perform pre-formulation studies of pharmaceutical dosage forms. The objective of the present study was to evaluate the compatibility of the valsartan (VALS) with pharmaceutical excipients of common use including diluents, binders, disintegrants, lubricants and solubilising agents. Thermogravimetry (TG), derivative thermogravimetry (DTG), but especially differential scanning calorimetry (DSC) were used for a first screening to find small variations in peak temperature and/or their associated enthalpy for six drug/excipient mixtures (starch, cross caramelose sodique, microcrystalline cellulose 102, povidone K30, lactose monohydrate and magnesium stearate), which indicate some degree of interaction. Additional methods using Fourier transformed infrared spectroscopy (FT-IR) and X-ray powder diffraction (XRPD) confirmed the incompatibility of VALS with starch, povidone K30, lactose monohydrate and magnesium stearate. Those excipients should be avoided in the development of solid dosage forms.
The Relation between Suicide by Chemical Substances and the Level of Education
Authors: Dumbrava Dan Perju , Radu Carmen Corina , Tabian Daniel , Vesa Stefan Cristian , Fulga Iuliu , Chiroban Ovidiu
Published: January 2020

The study aimed to determine the influence of the levels of education among people that committed suicide by the use of chemical substances. Data were collected from 2 groups of subjects investigated at the Institute of Legal Medicine in Cluj-Napoca, between January 2012 and December 2016. The first group consisted of 20 deceased persons that committed suicide by chemical substances and the second group consisted of 13 persons that attempted suicide by chemical substances. We investigated the following data: gender, age and type of toxic substance, level of education, field of study, existence of mental illness or other attempts. Age was statistically significantly higher in successful suicides versus suicides attempts. The rest of the variables did not differ statistically significantly between groups, although a higher percentage of subjects with psychiatric illness were observed in the completed suicides group. Also, a higher percentage of subjects who attempted to commit suicide with combination of alcohol and other chemical substances were observed, without achieving statistical significance. We also analyzed the differences within the group with completed suicide subjects from the point of view of their studies. Although we did not get a statistical significance because of the low number of subjects, there were a few associations that slightly exceeded the statistical significance threshold. Thus, those without higher education have used alcohol more frequently in combination with medication, and those with higher education have preferred medication alone. The obtained results may have implications for the targeted prevention of suicides by chemical substances.
Gastric Cancer in Pregnancy
Authors: Tomescu Aneta , Tomescu Cezar , Aschie Mariana , Stanciu Gabriela , Sirbu Rodica , Tica Vlad , Brezeanu Dragos
Published: January 2020

Gastric cancer is an uncommon occurrence in pregnancy, but its prognosis is grim. The co-occurrence of these two symptoms makes it almost impossible for one to suspect a diagnosis of gastric cancer in a pregnant woman. Herein, we present the case of a pregnant patient, diagnosed with gastric cancer at a gestational age of 24 weeks.
Evaluation of Total Phenolic Content in Relation to Antioxidant Activity of Brown Algae Cystoseira barbata from Black Sea
Authors: Cadar Emin , Sirbu Rodica , Ibram Alef , Ionescu Ana Maria
Published: January 2020

Seaweeds are widely used in the life science as source of compounds with diverse structural forms and biological activities, therefore, potential source of new antioxidant activity. The algae of the Black Sea have not been adequately explored for their potential as a source of bioactive substances. In this context, Brown algae Cystoseira barbata isolated from Black Sea coastal waters of Romania, were evaluated for their bioactivity potential. The results from Cystoseira barbata were obtained: for total phenolic content obtained in ethanolic extracts (TPC): 385.6 � 1.85 mg GAE/100 g f.w. Phenolic Acids quantified by HPLC-DAD from hydroethanolic extract of Cystoseira barbata from Black Sea was 80.14% from total phenolic content identified. We showed that Cystoseira barbata from the Romanian shore of the Black Sea contains vanillic acid in highest quantity (99.5�0.08 mg/100 g f.w.), followed by benzoic acid (65.7�0.06 mg/100 g f.w.) and feluric acid (54.5�0.01 mg/100 g f.w.). The smallest quantities were for gallic acid (3.5�0.03 mg/100 g f.w.), pyrogallol acid (4.2�0.05 mg/100 g f.w.) and 4-amino-benzoic acid (5.2�0.09 mg/100 g f.w.). Cystoseira barbata has a total content of large phenols and also has strong antioxidant and antimicrobial activity. Antioxidant activity (ACL) was studied using DPPH radical scavenging activity and reducing power. The extracts containing high levels of total phenolic content were also potent DPPH radical scavengers. The IC50 (�g/mL) for Cystoseira barbata in methanolic extract was 942.92� 2.56 �g/mL. High absorbance obtained from reducing power assay indicates high reducing power, measured values of absorbance varied from 0.0901 at 0.9223.
Anaplastic Lymphoma Kinase (ALK) Overexpression in Lung Cancer Biopsies - An 18 month study in north western Romania
Authors: Pop Ovidiu Laurean , Judea Pusta Claudia Teodora , Buhas Camelia Liana , Judea Adrian Sorin , Huniadi Anca , Jurca Claudia , Sandor Mircea , Negrutiu Bianca Maria , Buhas Bogdan Adrian , Nikin Zoran , Pascalau Andrei
Published: January 2020

Lung cancer is the first cause of death worldwide of oncological patients. Most of them are non-small cell lung cancer (NSCLC) and many of them are characterized by different molecular markers that allow the development of personalized treatments. Epithelial growth factor receptor (EGFR) and anaplastic lymphoma kinase (ALK) are the most frequently tested genes in lung adenocarcinoma and other lung carcinomas with glandular component. The aim of our study is to evaluate the distribution of ALK gene mutation in lung cancer patient from North West part of Romania. We analysed a number of 289 lung biopsies along 18 months. The samples have been incubated with monoclonal ALK antibodies (clone D5F3), according to the manufacturer�s instruction. The interpretation guide provided by manufacturer was used to distinguish the positives vs negative cases. In our study from a total number of 289 lung biopsies, 196 cases were carcinomas. 57.65 % from the total number of lung cancers were adenocarcinomas. A total number of 79 cases have been analysed for ALK gene supra expression. 5.08 % of adenocarcinomas were positive for ALK, but the mean age for this population is higher comparing with the data from other studies.
Glioblastoma Multiforme with Atypical Appearance
Authors: Grigorie Anca Alexandra , Schenker Ramona Adriana , Schenker Michael
Published: January 2020

We present the case of a 68-year-old patient who is hospitalized in our clinic for cognitive and attention disorders, progressively progressing over the past three months. The neurological examination revealed, besides cognitive decline, a motor deficit in the right limbs, and mild swallowing disorders for liquids. Although both CT and MRI were performed, the images obtained from the investigations were inconclusive, raising differential diagnosis problems. The patient was subjected to additional investigations, but the diagnosis of certainty was established by performing sterotactic biopsy and histological examination. Although cerebral MRI is the investigation of choice in the diagnosis of glioblastoma, in our patient�s case, the diagnosis of certainty was determined by stereotactic biopsy and subsequent histological examination.
The width and scope of intelligence studies in business
Authors: Solberg Soilen Klaus
Published: January 2020

If the last issue of JISIB was a special issue where the discipline was reflecting on itself, then this issues shows some of the width and scope of the field. The conceptual article by Nienaber and Sewdass presents a relatively new concept of workforce intelligence, and links it to competitive advantage by way of predictive analytics. The article by Solberg Søilen is an attempt to lay out a broad scientific agenda for the area of intelligence studies in business.Empirical findings come from a survey, but in the discussion the author argues for why the study should define itself as much broader than what the survey data implies, breaking out of the current dominating scientific paradigm. The article by Fourati-Jamoussi and Niamba is an updated evaluation of business intelligence tools, a frequently reoccurring topic. However, this time it is not a simple evaluation of existing software, but an evaluation by users to helpdesigners of business intelligence tools get the best efficiency out of a monitoring process. The article by Calof is an evaluation of government sponsored competitive intelligence for regional and sectoral economic development in Canada. The article concludes that it is possible tocalculate positive economic impacts from these activities. Rodríguez Salvador and Hernandez de Menéndez come back to a field that has become a specialty for Rodríguez Salvador: scientific and industrial intelligence based on scientometric patent analysis. This time she looks at bio-additive manufacturing using advanced data mining software and interviews with experts.
Implicaciones de la clasificación del equilibrio dinámico en jugadoras de fútbol para variables funcionales. Estudio clínico de intervención.
Authors: Martínez-Martínez Elena , Manrique-Ortiz Carlos , García-Muñoz Daniel
Published: January 2020

Objetivo: Comparar los efectos de un protocolo de fútbol simulado con el SAFT 90, en jugadoras de fútbol femenino con equilibrio dinámico y con desequilibrio dinámico en miembro inferior.Diseño: Ensayo clínico no controlado.Marco: Centros participantes: Universidad La Salle Madrid y Equipo Madrid Club de Fútbol Femenino.Participantes: Los criterios de inclusión fueron: mujeres que practicaran fútbol amateur al menos 2 veces a la semana, asintomáticas y ausencia de lesiones deportivas en los últimos 6 meses. 21 jugadoras de fútbol femenino fueron divididas en dos grupos, (10 jugadoras sin equilibrio dinámico y 11 jugadoras con equilibrio dinámico).Intervenciones: El desarrollo, la medición y ejecución de las pruebas de la investigación se realizaron en un solo día. Las participantes fueron valoradas por las distintas pruebas antes de la realización del protocolo SAFT 90 y tras la ejecución del protocolo se repitieron las mismas pruebas de valoración. Estas pruebas fueron: El Y Balance Test, El test del salto con caída previa (SCCP), el test de Salto con contramovimiento (SCC) y dinamometría de la musculatura isquiotibial.Variables: Rigidez de los Tejidos Pasivos (RTP), Índice de Fuerza Reactiva (IFR), tiempo de contacto, velocidad, tiempo de vuelo, fuerza explosiva, potencia y fuerza isométrica.Resultados: Los resultados mostraron un aumento de la RTP (P= 0,03), aumento del IFR (P= 0,03), disminución de la velocidad (P= 0,04) y disminución en el tiempo de Contacto (P= 0,02) en el grupo de las jugadoras sin equilibrio dinámico frente al grupo de jugadoras con equilibrio dinámico.Conclusión: Las jugadoras de fútbol femenino con desequilibrio dinámico de miembros inferiores tienen diferencias después de una intervención de fútbol simulado, asociándose con mayor riesgo de lesión.
Efectos de un programa de ejercicios de control motor en la región abdominopélvica sobre la capacidad pulmonar en sujetos sanos: Ensayo controlado aleatorizado
Authors: Bonilla-Penedo Celia , Madrid-Crespo Silvia , Olagüe-Silió Iñigo , Del Corral Tamara
Published: January 2020

Objetivo: Evaluar la influencia de un programa de ejercicios de control motor orientados a la región abdominopélvica, en la mejora de la fuerza de los músculos respiratorios, la capacidad pulmonar y de variables posturales en sujetos sanos.Diseño: Ensayo controlado, aleatorizado y a simple ciegoMarco: Campus Universitario.Participantes: 65 sujetos sanos, con edades comprendidas entre los 18 y 57 años, con una media de 26,36±11,34 añosIntervenciones: La muestra se clasificó aleatoriamente en dos grupos: control (n=31) y experimental (n=30). El grupo control no recibió intervención alguna. El grupo experimental fue sometido a un tratamiento de cuatro semanas de duración mediante un protocolo de ejercicios de control motor sobre la región abdominopélvica, con especial incidencia en el músculo transverso del abdomen, junto con ejercicios de control de la respiración.Variables: Ambos grupos realizaron las mismas mediciones antes y tras cuatro semanas. Como variables principales se midieron las presiones respiratorias máximas, tanto la inspiratoria (Pimax) como la espiratoria (Pemax), y como variables secundarias se consideraron la evaluación de la cabeza adelantada, de la cifosis torácica, de la estabilidad lumbar y de la función pulmonar.Resultados: El grupo experimental mostró diferencias significativas para las siguientes variables del estudio tras la intervención: Pimax -10 (-14,8 a -5,2) cmH2O p=0,001; Pemax -6,37 (-10,7 a -2,03) cmH2O p=0,005; estabilidad lumbar 1,98 (0,4 a 3,57) mmHg p=0,015 y flujo espiratorio máximo -0,42 (-0,83 a -0,01) litros p=0,047. Analizando los cambios entre ambos grupos, sólo el volumen espiratorio forzado el primer segundo (FEV1) -6,21% litros (-12,44 a 0,03) p=0,05 obtuvo una diferencia estadísticamente significativa.Conclusión: La realización de un programa de ejercicios de control motor orientado a la región abdominopélvica, supone una mejora en la fuerza de los músculos respiratorios, en la estabilidad lumbar y en el grado de obstrucción bronquial en sujetos sanos. El resto de parámetros recogidos en la función pulmonar, así como las variables posturales (cabeza adelantada y cifosis torácica) no sufrieron cambios significativos tras la intervención.
Los efectos de la imaginería motora en el control postural: Un estudio longitudinal en sujetos sanos
Authors: Zamarro-Rodríguez Belén , Cuesta-García César , Lerma-Lara Sergio
Published: January 2020

Objetivo: Determinar los efectos de la imaginería motora sobre el control postural en bipedestación, postural de partida de una gran variedad de ocupaciones humanas.Diseño: Estudio piloto experimental, de corte longitudinal.Marco: Ámbito universitarioParticipantes: Quince sujetos sanos de ambos sexos, con edades comprendidas entre los 18-30 años.Intervenciones: Fueron evaluados en bipedestación sobre una plataforma dinamométrica computarizada (Neurocom) mediante el test de organización sensorial. Mientras se realizaban las pruebas, debían imaginarse dos situaciones: 1) Una situación de estabilidad, poniendo el foco atencional en el feedback intrínseco y 2) Otra situación dinámica, poniendo el foco atencional en el feedback extrínseco. Un relato auditivo, acompañado de efectos sonoros, fue añadido al procedimiento de imaginería motora.Variables: Puntuaciones en el equilibrio, estrategias somatosensoriales, desplazamiento del centro de gravedad, el perfil sensorial.Resultados: El análisis reveló diferencias significativas (p<0,01) en las variables cuando los participantes imaginaban la situación de estabilidad. Se comprobó una relación entre dichos resultados y la puntuación del perfil sensorial.Conclusión: La imaginería motora, es un procedimiento que ha demostrado influencias en la mejora del control postural en bipedestación y puede ser una técnica que complemente el tratamiento de pacientes con alteraciones posturales y del equilibrio.
Influencia de las expectativas sobre la fuerza de prensión manual en sujetos asintomáticos. Ensayo piloto aleatorizado a simple ciego
Authors: Cuenca-Martínez Ferran , Suso-Martí Luis , Cabañas-García Cristina , Gil-Martínez Alfonso
Published: January 2020

Objetivo: Evaluar cómo las expectativas, inducidas de forma escrita, influyen en la fuerza de prensión manual, en la intensidad de dolor y en variables somato-sensoriales.Diseño: Ensayo piloto controlado y aleatorizado a simple ciegoMarco: Campus Universitario.Participantes: Los criterios de inclusión fueron: sujetos sanos, sin dolor y en edades comprendidas entre 18 y 30 años. Una muestra total de 39 sujetos sanos participaron en el presente estudio piloto y fueron asignados aleatoriamente en tres grupos según la expectativa, la cual podía ser positiva, negativa o neutra, dada por escritoIntervenciones: Tras asignar la muestra de manera aleatoria a los tres grupos de expectativas, se les aplicó una corriente de neuro-estimulación eléctrica transcutánea (TENS) de corta duración y sin efecto terapéutico.Variables: La variable principal fue la fuerza de prensión manual. Las variables secundarias fueron la intensidad de dolor, los umbrales de dolor a la presión y la sumación temporal en zona epicondilar. En primer lugar, se recogieron los valores pre-intervención y tras la intervención, se recogieron los datos de las variables de interés en dos tiempos. Primero, inmediatamente después de la intervención y segundo, a los 5 minutos de la misma.Resultados: No se encontraron diferencias estadísticamente significativas en relación a la influencia de las expectativas con el cambio de la fuerza de prensión manual (p > 0,05). No se encontraron diferencias estadísticamente significativas en la sumación temporal, ni en los umbrales de dolor a la presión. El dolor post-intervención fue mayor en el grupo de expectativas negativas y este fue el único grupo que mantuvo el dolor a los 5 minutos tras finalizar la intervención.Conclusión: A pesar de las tendencias observadas, no se encontraron influencias estadísticamente significativas de las expectativas sobre la fuerza muscular de prensión manual, ni en la intensidad de dolor, ni en variables somato-sensoriales. Las expectativas negativas influyeron en el dolor post-intervención.
Pelatihan Penghitungan Harga Pokok Produk dengan Metode Job Order Costing pada WF Printing
Authors: Fadrul Fadrul , Irman Mimelientesa , Rahman Sarli , Ayu Purwati Astri
Published: January 2020

Artikel ini membahas tentang kegiatan pelatihan penghitungan harga pokok produk (HPP) dengan metode job order costing pada WF Printing. Pelatihan ini dilakukan kepada karyawan WF Printing dengan sampel yang digunakan yaitu faktur berukuran ¼ folio dan 1/3 folio. Hasil dari pelatihan ini menunjukkan bahwa dalam menjalankan usahanya WF Printing belum melakukan penghitungan HPP secara tepat, sehingga berdampak terhadap harga jual dan profit yang didapatkan. Diharapkan, dengan adanya pelatihan ini pemilik usaha dapat menerapkan dan melakukan penghitungan HPP secara tepat.
Detecting Heart Rate Using Pulse Sensor As Alternative Knowing Heart Condition
Authors: Irawan Yuda , Fernando Yunior , Wahyuni Refni
Published: January 2020

Medical check-up done at the hospital for the first time is a heartbeat. This is done because the heart of the human body is the main organ, where the work function of the heart affects other important organs of humans. Based on these conditions, human heart health must be really considered. Things that can be done early is by checking the heart rate regularly. not everyone can do medical check-ups regularly. Even though by knowing the condition of a person's heartbeat, health will be maintained, it does not need expensive care from a doctor, but with a regular lifestyle, everything will be resolved. In this study, the researchers designed to measure heart rate as an alternative in maintaining health, using pulse sensors and Arduino circuits. This study resulted in a heart rate application system as a control to monitor the condition of the patient's heart rate, can provide information about the heart rate that uses the pulse sensor to patients and doctors who have an application to read the heart rate that has been made.
Licensing Information System In Kesbangpol Kota Pekanbaru
Authors: Sadar Muhammad , Siswanto Didik , Handayani Susi
Published: January 2020

The development of computer technology now enables the development of computer-based information systems, so the Community Organization (ORMAS) licensing service at the National Unity and Politics Agency (Bakesbangpol) Pekanbaru City needs support from technological developments to reduce existing problems items, namely the lack of information for ORMAS administrators who want to extend the Certification of registration Community Organization ORMAS SKT, and SKT ORMAS when registering. The purpose of this research is to Facilitate all forms of licensing at the Kesbangpol office, so that the process can be more efficient in terms of time and cost. The system that will be created is a Web-based application, the design is done using Unified Modeling Language (UML) and making the system using the PHP programming language, and using a MySQL database
Pengaruh Kepemimpinan terhadap Disiplin Kerja Pegawai Kantor Kementerian Agama Kota Bukittinggi dengan Motivasi Kerja Sebagai Variabel Moderating
Authors: Suryanto Dasep
Published: January 2020

The results showed that the influence between leadership and work discipline was significant. The influence between leadership and work motivation was also significant. The influence between work motivation cannot strengthen the leadership relationship to Work Discipline and is not significant. with a T-statistic of 1,2572541846236 (<1,960). The original sample estimate value is negative, amounting to -0.13494828, which shows that the direction of the relationship between Leadership and Work Discipline which is moderated by motivational variables has a negative and insignificant effect, while the influence between leadership and work discipline at the Office of the Ministry of Religion in Bukittinggi has a positive influence. and significant, so does the influence of leadership on motivation has a positive and significant influence and finally the influence of motivation on work discipline at the Office of the Ministry of Religion in Bukittinggi has a positive and significant effect so that all hypotheses submitted can be accepted except the leadership hypothesis in moderation of work motivation variables working discipline at the Bukittinggi City Ministry of Religion's Office is unacceptable.

Keywords: Leadership, Motivation and Discipline
PENGARUH PEMAHAMAN AKUNTANSI DAN PENERAPAN SISTEM INFORMASI KEUANGAN DAERAH TERHADAP KUALITAS LAPORAN KEUANGAN PEMERINTAH DAERAH DENGAN KOMPETENSI SUMBER DAYA MANUSIA SEBAGAI VARIABEL MODERASI (STUDI EMPIRIS PADA PEMERINTAH KOTA PEKANBARU)
Authors: Yeni Elfita , Irman Mimelientesa , Fadrul Fadrul
Published: January 2020

This study aims to determine the influence of Accounting Understanding an Application, financial accounting systems human resource competency on the quality of regional financial statement. Based on PP No. 71 year 2010, state and local government financial statement quality have to meet the qualitative characteristic. Factors examined include Acounting understanding, human resource competency financial accounting system and the quality of regional financial statement. The used sampling method is purposive sampling sampling. Data collection is done by giving as many as 90 copies, copies of the questionnaire,which was distributed to respondents who are staff  financial in Pekanbaru City. The Data obtained are then analyzed using SPSS 21.00. Based on the analysis results, obtained that applicatin of Accounting and the financial accounting systems have a positive and significant effect to the quality of financial reporting information in OPD Pekanbaru City and human resource competency can be used as a moderating variable.
Introduction
Authors: Williams James
Published: January 2020

The introduction establishes some preliminary understandings that underpin the approach taken in this study of Lear. It asks whether nonsense is amenable to critical analysis, and how far “nonsense” will take us as a critical term for understanding Lear’s work, and considers the relationship between Lear’s work, morality and moralism. It presents the overarching argument of the book, that Lear’s nonsense is, without being moralistic, a moral art in that its representations of the absurdities of human experience are grounded in a cultivation of the capacity to see ourselves from various kinds of external perspective