bluuebunny/crossref_metadata_2025 huggingface dataset:
In situ analyses of crystallization behavior of 1,2,3-tripalmitoyl glycerol under static and dynamic thermal conditions
Authors: Bayés-García Laura , Macridachis Jorge , Calvet Teresa , Sato Kiyotaka
Published: May 2024

The crystallization behavior of 1,2,3-tripalmitoyl glycerol or PPP using differential scanning calorimetry (DSC), thermo-optical polarized light microscopy and in situ synchrotron radiation X-ray diffraction (SR-XRD) techniques was precisely examined under static isothermal and dynamic thermal treatments, and the results were compared with preceding studies. PPP was rapidly (15 °C min−1) cooled to target temperatures (from 40 to 59 °C) to determine the precise moment at which crystallization was initiated. Once crystallization ceased, polymorphic transformation and melting were analyzed during subsequent heating. α form was crystallized during isotherms from 40 to 46 °C, temperature at which it coexisted with β′ phase. The latter was solely formed from 47 to 53 °C, and polymorphic crystallization was directed to obtain exclusively most stable β at 54 °C and higher temperatures. Nucleation time values for the α, β′ and β polymorphs exhibited exponential growth type, and a good correlation was found between data obtained by DSC and SR-XRD. Dynamic experiments were based on the use of high (15 °C min−1), intermediate (2 °C min−1) and low (0.5 and 0.1 °C min−1) cooling and heating rates. Thermo-optical polarized light microscopy experiments also provided valuable information on microstructural changes occurring during polymorphic modifications. Less stable forms predominated at high cooling rates, whereas lower velocities leaded the polymorphic crystallization to obtain more stable forms.
Making things specific: towards an anthropology of everyday ethics in healthcare
Authors: Pols Jeannette
Published: May 2024

This paper is the English translation and adaptation of my inaugural lecture in Amsterdam for the Chair Anthropology of Everyday Ethics in Health Care. I argue that the challenges in health care may look daunting and unsolvable in their scale and complexity, but that it helps to consider these problems in their specificity, while accepting that some problems may not be solved but have become chronic. The paper provides reflections on how to develop a scientific approach that does not aim to eradicate bad things but explores ways in which to live with them. Crucial in this quest is the attention to how we conceptualize problems, and whether this is specific enough for addressing present day concerns. I propose an anthropology of everyday ethics as a way to study people’s everyday ways of handling a variety of goods in practice. I draw specific attention to exploring aesthetic values in everyday life amongst these, values that are used abundantly to qualify events in everyday life but rarely theorized in philosophy or social science.
Flood resilience: a review of evolving definitions
Authors: Laidlaw Sophie , Percival Sarah
Published: May 2024

Flooding is one of the most complicated and prolific natural hazards that communities face. Added to this, more people will be affected by this hazard than any other in the future. Within recent years, there has been a notable shift in flood risk management from risk-based approaches to resilience-based. Considered a novel and necessary approach, yet no single definition of flood resilience exists. Leading to confusion surrounding the applicability of the concept. A systematic review of flood resilience definitions was hence conducted, covering a 5-year period from 2017 to 2021, resulting in 65 papers, supplemented by a narrative review (to include papers outside of the scope of the study), which added a further 11 papers. Results indicated that whilst there is no singular definition for flood resilience, there are similarities between definitions through the use of synonymous language. Whilst there is evidence of these definitions evolving over time, there is still confusion over the definition. Further research is required to further comprehend the definitions of resilience, helping to develop the use of resilience within flood sciences and corresponding flood risk management practices.
Century-long recovery of mycorrhizal interactions in European beech forests after mining
Authors: Rodríguez-Uña Asun , Salcedo Isabel , Rodríguez-Echeverría Susana , Moreno-Mateos David
Published: May 2024

Background and aims

Ecological restoration strategies are emerging globally to counteract biodiversity loss and ecosystem degradation. However, restored ecosystems may not reach undisturbed biodiversity and functionality. One reason of this limited success may be a focus on short-term recovery of diversity, composition, or isolated functions. These simplified metrics may underestimate the real time ecosystems need to recover. Thus, studies of more complex metrics, like biotic interactions, at larger timescales, are essential to understand ecosystem recovery.

Methods

Using molecular identification, we assessed the recovery of the interactions between ectomycorrhizal (EcM) fungi and European beech (Fagus sylvatica L.) in two opencast iron mines in use since the fourteenth century and abandoned over 107 and 148 years.

Results

Species richness, species diversity, Basidiomycota/Ascomycota abundance ratio and taxonomic distinctness of EcM fungi recovered to undisturbed values, whereas species composition was still different. Certain fungal functional traits (i.e. exploration and sporocarp types) also reached undisturbed values. Differences in soil pH and NH4+ affected the composition of the EcM communities associated with beech, suggesting that mining caused a long-term impact in soil biogeochemistry, that directly impacted beech-EcM interactions.

Conclusion

Mycorrhizal interactions require more than 150 years to recover following mining. Contrary to the rapid recovery response provided by simple metrics like species richness, recovery metrics with more ecological information, like the identity of plant-EcM interactions, may be still capturing signals of incomplete recovery.
Teaching as part of open scholarship: developing a scientometric framework for Open Educational Resources
Authors: Kullmann Sylvia , Weimer Verena
Published: May 2024

Scientometric assessments of Open Educational Resources (OER) offer a way to quantitatively represent teaching in higher education through openly available and accessible artefacts. They could serve science policy monitoring and lead to greater visibility of higher education teaching in a recognition and reward system. In this context, we discuss possible statistics for OER. In a pre-study, a first version of OER indicators was discussed in three focus groups. The findings of these discussions were incorporated into the creation of a more comprehensive second version of a framework for OER statistics, which was evaluated in detail in six expert interviews. After incorporating changes as a result of the evaluation, a third version of the framework for OER statistics emerged that enables scientometric measurements of OER, while considering the common criticisms of scientometric measurements. The framework comprises an individual level, which recognizes all OER created by an individual, and an institutional level, which serves to quantify OER created by an institution. At the individual level, productivity, cooperation, resonance, openness, altmetric and transfer indicators are available. In addition, we record dichotomously whether an OER certification exists. At the institutional level, additional support indicators are proposed to recognize achievements in the development and maintenance of OER-promoting structures at institutional level.
New fractional classifications of papers based on two generations of references and on the ASJC scopus scheme
Authors: Álvarez-Llorente Jesús M. , Guerrero-Bote Vicente P. , de Moya-Anegón Félix
Published: May 2024

This paper presents and evaluates a set of methods to classify individual Scopus publications using their references back to the second generation, where each publication can be assigned fractionally into up to five ASJC (All Science Journal Classifications) categories, excluding the Multidisciplinary area and the miscellaneous categories. Based on proposals by Glänzel et al. (Glänzel et al., Scientometrics 44:427–439, 1999a, Glänzel et al., Scientometrics 46:431–441, 1999b, Glänzel, W., Thijs, B., & Huang, Y. (2021). Improving the precision of subject assignment for disparity measurement in studies of interdisciplinary research. In: W. Glänzel, S. Heeffer, PS. Chi, R. Rousseau (eds), Proceedings of the 18th International Conference of the International Society of Scientometrics and Informetrics (ISSI 2021), Leuven University Press, pp. 453–464. https://kuleuven.limo.libis.be/discovery/fulldisplay?docid=lirias3394551&context=SearchWebhook&vid=32KUL_KUL:Lirias&search_scope=lirias_profile&tab=LIRIAS&adaptor=SearchWebhook&lang=en), some additional parameters are established that allow different results to be obtained depending on how category membership is weighted or how the acceptance thresholds for multiple assignments are established. Various classifications are obtained, and then compared with each other, with the original ASJC Scopus journal classification, and with the AAC (Author’s Assignation Collection) classification of a previous study (Álvarez-Llorente et al., Álvarez-Llorente et al., Profesional de la Información, 2023) in which the papers’ corresponding authors assign them the most appropriate categories. Classifications in which a high threshold is set for allowing assignments to multiple categories, combined with the use of first- and second-generation references and averaging over the number of references, provide the most promising results, improving over other reference-based reclassification proposals in terms of granularity, and over the Scopus classification itself in such aspects as the homogeneity of the publications assigned to a category. They also show greater coincidence with the AAC classification.
Gaitdlf: global and local fusion for skeleton-based gait recognition in the wild
Authors: Wei Siwei , Liu Weijie , Wei Feifei , Wang Chunzhi , Xiong Neal N.
Published: May 2024

A new trend in long-range biometrics, gait recognition, is finding application in a number of different fields including video surveillance. Recently, with the increase in robustness of the pose estimator and the presence of various unpredictable factors in realistic gait recognition, skeleton-based methods with higher robustness have emerged to better meet the challenging gait recognition needs. However, existing approaches primarily focus on extracting global skeletal features, neglecting the intricate motion information of local body parts and overlooking inter-limb relationships. Our solution to these challenges is the dynamic local fusion network (GaitDLF), a novel gait neural network for complex environments that includes a detail-aware stream in addition to the previous direct extraction of global skeleton features, which provides an enhanced representation of gait features. To extract discriminative local motion information, we introduce predefined body part assignments for each joint in the skeletal structure. By segmenting and mapping the overall skeleton based on these limb site divisions, limb-level motion features can be obtained. In addition, we will dynamically fuse the motion features from different limbs and enhance the motion feature representation of each limb by global context information and local context information of the limb-level motion features. The ability to extract gait features between individuals can be improved by aggregating local motion features from different body parts. Based on experiments on CASIA-B, Gait3D, and GREW, we show that our model extracts more comprehensive gait features than the state-of-the-art skeleton-based method, demonstrating that our method is better suited to detecting gait in complex environments in the wild than the appearance-based method.
Effects of nitrogen deficiency and drought stresses on miRNA expressions in Arabidopsis thaliana
Authors: Yaşar Seda , Pulat Elif , Çakır Özgür
Published: May 2024

MicroRNAs are now known to have an important role in regulating gene expression of eukaryotic organisms. miRNA research in plants gained importance after the discovery that several stress factors alter certain miRNA expressions, which subsequently regulate their target gene expressions and affect development and growth of plants. In this study, two of the widely studied abiotic stress conditions for plants, nitrogen deficiency and drought were used individually and as a combined stress treatment on Arabidopsis thaliana callus tissues to observe the change of expressions in certain miRNAs, when multiple stressors are encountered. Combined stress strongly inhibited callus growth compared to other conditions, while strongly altering certain miRNA expressions. Compared to control, in 7-day stress treated callus, miR165a-3p,b, miR319a,b, miR396b-5p, miR399d and miR827 showed significant downregulation for all stress treatments, while 7-day N deficiency caused miR167 upregulation. Stress treatments for 7 days mostly downregulated miR167c-5p, miR319c, miR399a, miR399e expressions except for the N deficient samples. After 14 days of stress, miR165a-3p,b, miR396a-5p, miR399b, miR399d were downregulated. During 14-day drought and combined stress, miR399a and miR396b-5p expressions were upregulated, respectively. The differences observed in this study between stress responses of 7 and 14-day-long treatments are believed to be valuable to further elucidate the associated molecular mechanisms of miRNAs, determination and validation of miRNA targets, and how plants respond to stress conditions via various genetic regulations.
Assessment of Societal Health Risks: Spatial Distribution and Potential Hazards of Toxic Metals in Street Dust Across Diverse Communities
Authors: Isinkaralar Oznur , Isinkaralar Kaan , Ambade Balram
Published: May 2024

On a global scale, the urban design of city centers is a topic of discussion concerning various aspects such development and its impact on public health. This research examines the health effects of urban agglomeration in city centers with compact, close development. In this work, the potentially toxic metals in street dust were studied by collecting and measuring street dust samples, measuring trace metal concentrations, and using index assessment, spatial analysis, correlation analysis, and health risk assessment models. Eskişehir, located in the part of Central Anatolia close to the Aegean region, west Türkiye, has been widely recognized as one of the most popular, known for having many narrow and old buildings in urban environments. The present paper investigates the atmospheric dust-related chemical speciation, urban environmental pollution, and human health risks in Eskişehir City by studying 66 dust samples collected at 11 points in the selected streets in August 2023. the study found that the concentrations of trace elements followed the order Cr > Ni > Pb > Cd > Cu. The primary source of these high levels is believed to be traffic-related contamination involving Cd, Pb, and Ni. The assessment of non-carcinogenic health risks has shown that the significant sources of potential toxic metals exposure for both children and adults are i) through ingestion and ii) dermal contact. The Hazard index (HI) for selected metals decreased in the order Cr > Pb > Ni > Cd > Cu for both children and adults without imposing possible non-carcinogenic risk (HI<1). On the contrary, Cr posed cancer risks above the safety threshold (> 10-4) through ingestion. Based on the available findings, Eskişehir still suffers from considerable environmental and ecological degradation and severe health risks due to street dust contamination. However, while high pollution was detected in the city center, where there is commercial land use, low values were observed in the region, rich with the water surface, bicycle paths, landscape design, and where traffic is slowed down.
Quality assessment of biomass pellets available on the market; example from Poland
Authors: Drobniak Agnieszka , Jelonek Zbigniew , Mastalerz Maria , Jelonek Iwona , Widziewicz-Rzońca Kamila
Published: May 2024

This study evaluates the quality of 30 biomass pellets sold for residential use in Poland. It provides data on their physical, chemical, and petrographic properties and compares them to existing standards and the information provided by the fuel producers. The results reveal considerable variations in the quality of the pellets and show that some of the purchased samples are not within the DINplus and/or ENplus certification thresholds. Among all 30 purchased samples, only one passes the quality thresholds set by the PL-US BIO, a newly established quality certification in Poland that combines quality assessment following DINplus with optical microscopy analysis. The primary issues causing a decrease in pellet quality include elevated ash and fines content, compromised mechanical durability, too low ash melting temperature, and additions of undesired additions like bark, inorganic matter, and petroleum products. Our research highlights the need for improved fuel quality control measures, and transparent and accurate product labeling, as well as the need for a comprehensive and publicly available national database of solid biomass fuel producers and fuels sold. These are essential steps toward increasing customers’ awareness and trust, encouraging them to embrace biomass fuels as reliable and sustainable sources of energy.
Matching Mobile Crisis Models to Communities: An Example from Northwestern Ontario
Authors: Zitars Jillian , Scharf Deborah
Published: May 2024

Police are often the first to encounter individuals when they are experiencing a mental health crisis. Other professionals with different skill sets, however, may be needed to optimize crisis response. Increasingly, police and mental health agencies are creating co-responder teams (CRTs) in which police and mental health professionals co-respond to crisis calls. While past evaluations of CRTs have shown promising results (e.g. hospital diversions; cost-effectiveness), most studies occurred in larger urban contexts. How CRTs function in smaller jurisdictions, with fewer complementary resources and other unique contextual features, is unknown. This paper describes the evaluation of a CRT operating in a geographically isolated and northern mid-sized city in Ontario, Canada. Data from program documents, interviews with frontline and leadership staff, and ride-along site visits were analyzed according to an extended Donabedian framework. Through thematic analysis, 12 themes and 11 subthemes emerged. Overall, data showed that the program was generally operating and supporting the community as intended through crisis de-escalation and improved quality of care, but it illuminated potential areas for improvement, including complementary community-based services. Data suggested specific structures and processes of the embedded CRT model for optimal function in a northern context, and it demonstrated the transferability of the CRT model beyond large urban centres. This research has implications for how communities can make informed choices about what crisis models are best for them based on their resources and context, thus potentially improving crisis response and alleviating strain on emergency departments and systems.
Strength-Based Learning: An Autoethnography of an Introductory Instructional Design Graduate Course
Authors: Giacumo Lisa A.
Published: May 2024

The purpose of this article is to investigate how to use a strengths-based lens that is highly contextualized, in an ecology (i.e., online graduate course) that shows the value of the socio-emotional interactions or climate. I used an autoethnographic approach to problematize myself so that I could ask contemplative questions as a result of reflection. My data collection process drew upon personal narrative, reflection, and anecdotes, which I analyzed in a graduate-level online learning context with a strengths-based lens to shed light on broader U.S. higher education online learning cultural and theoretical concepts such as organizational justice theory, connectivism, digital learning ecosystems, inclusive design, design justice, and strengths-based learning approaches. Three key cultural phenomena are revealed in this autoethnography. Finally, I discuss this study’s limitations, some implications for faculty, IDs, and SMEs, and suggest areas for further research.
Proximal gradient methods with inexact oracle of degree q for composite optimization
Authors: Nabou Yassine , Glineur François , Necoara Ion
Published: May 2024

We introduce the concept of inexact first-order oracle of degree q for a possibly nonconvex and nonsmooth function, which naturally appears in the context of approximate gradient, weak level of smoothness and other situations. Our definition is less conservative than those found in the existing literature, and it can be viewed as an interpolation between fully exact and the existing inexact first-order oracle definitions. We analyze the convergence behavior of a (fast) inexact proximal gradient method using such an oracle for solving (non)convex composite minimization problems. We derive complexity estimates and study the dependence between the accuracy of the oracle and the desired accuracy of the gradient or of the objective function. Our results show that better rates can be obtained both theoretically and in numerical simulations when q is large.
Enhancing Primary Care and Mental Health Integration for Women Veterans with Complex Healthcare Needs Using Evidence-Based Quality Improvement
Authors: Clair Kimberly S. , Yano Elizabeth M. , Fickel Jacqueline J. , Brunner Julian , Canelo Ismelda , Hamilton Alison
Published: May 2024

Background

Women Veterans with co-morbid medical and mental health conditions face persistent barriers accessing high-quality health care. Evidence-based quality improvement (EBQI) offers a systematic approach to implementing new care models that can address care gaps for women Veterans.

Objective

This study examines factors associated with the successful deployment of EBQI within integrated health systems to improve primary care for women Veterans with complex mental health needs.

Design

Following a 12-site (8 EBQI, 4 control) cluster randomized study to evaluate EBQI effectiveness, we conducted an in-depth case study analysis of one women’s health clinic that used EBQI to improve integrated primary care–mental health services for women Veterans.

Participants

Our study sample included providers, program managers, and clinic staff at a women Veteran’s health clinic that, at the time of the study, had one Primary Care and Mental Health Integration team and one women’s health primary care provider serving 800 women. We analyzed interviews conducted 12 months, 24 months, and 4 years post-implementation and call summaries between the clinic and support team.

Main Measures

We conducted qualitative thematic analysis of interview and call summary data to identify EBQI elements, clinic characteristics, and reported challenges and successes within project development and execution.

Key Results

The clinic harnessed core EBQI elements (multi-level stakeholder engagement, data-driven progress-monitoring, PDSA cycles, sharing results) to accomplish pre-defined project goals, strengthen inter-disciplinary partnerships, and bolster team confidence. Clinic characteristics that facilitated implementation success included prior QI experience and an organizational culture responsive to innovation, while lack of pre-existing guidelines and limited access to centralized databases posed implementation challenges.

Conclusions

Successful practice transformation emerges through the interaction of evidence-based methods and site-specific characteristics. Examining how clinic characteristics support or impede EBQI adaptation can facilitate efforts to improve care within integrated health systems.
Post-Radiotherapy Dysphagia in Head and Neck Cancer: Current Management by Speech-Language Pathologists
Authors: Govender Roganie , Gilbody Nicky , Simson Gavriella , Haag Rhiannon , Robertson Ceri , Stuart Emma
Published: May 2024

Opinion statement

Dysphagia, difficulty in eating and drinking, remains the most common side effect of radiotherapy treatment for head and neck cancer (HNC) with devastating consequences for function and quality of life (QOL). Over the past decade, 5-year survival has improved due to multiple factors including treatment advances, reduction in smoking, introduction of the human papillomavirus (HPV) vaccine and more favourable prognosis of HPV-related cancers. Increased prevalence of HPV-positive disease, which tends to affect younger individuals, has led to an elevated number of people living for longer with the sequelae of cancer and its treatment. Symptoms are compounded by late effects of radiotherapy which may lead to worsening of dysphagia for some long-term survivors or new-onset dysphagia for others. Speech-language pathology (SLP) input remains core to the assessment and management of dysphagia following HNC treatment. In this article, we present current SLP management of dysphagia post-radiotherapy. We discuss conventional treatment approaches, the emergence of therapy adjuncts and current service delivery models. The impact of adherence on therapy outcomes is highlighted. Despite treatment advancements, patients continue to present with dysphagia which is resistant to existing intervention approaches. There is wide variation in treatment programmes, with a paucity of evidence to support optimal type, timing and intensity of treatment. We discuss the need for further research, including exploration of the impact of radiotherapy on the central nervous system (CNS), the link between sarcopenia and radiotherapy-induced dysphagia and the benefits of visual biofeedback in rehabilitation.
Exploring Functionality Gain for (Recombinant) β-Lactoglobulin Through Production and Processing Interventions
Authors: Hoppenreijs Loes J. G. , Brune Sarah E. , Biedendieck Rebekka , Krull Rainer , Boom Remko M. , Keppler Julia K.
Published: May 2024

Interventions in the upstream production and further processing of recombinant food proteins affect its properties when used for food application. Often the efficiency of particular interventions is evaluated based on molecular purity and yield rather than final functional properties. Yet, the formulation of foods, including the amount of protein required, can be affected when the functional properties have changed. In this explorative study, we exemplify how far we can extend the functionality range of the major whey protein β-lactoglobulin (BLG), in terms of foaming and (heat-set) gelling, through various interventions. Slight changes in the amino acid sequence of BLG affected its functional properties significantly. Foams were up to ten times more stable, when selecting different natural isoforms of BLG (isoform A instead of B) or when inducing targeted cysteine mutations. The isoform B yielded stronger thermally induced gels (+ 40%) compared to isoform A. During downstream processing of recombinantly secreted BLG, limited purification of up to ~ 67 wt% enabled reasonable foaming properties and superior gelation, while a lower purity of ~ 22 wt% resulted in poor performance in both cases. Post-processing allowed conversion of native whey protein into soluble amyloid-like aggregates. These aggregates resulted in better foam stability (i.e., approximately four times longer than non-aggregated protein), but did not improve gelation. The presented study demonstrates that one should consider not only protein yield and purity, but also functional properties when developing recombinant proteins for food application. In turn, these functional properties are a result of the complete upstream and downstream chain.
Comparative Selective Conversion of Biomass-Derived Mono- and Polysaccharides into Lactic Acid with Lanthanide Lewis Acid Catalysts
Authors: Bermejo-López Alejandro , Illera Alba E. , Melgosa Rodrigo , Beltrán Sagrario , Sanz M. Teresa
Published: May 2024

Lanthanides were tested (Ce3+, Er3+, and Yb3+) as catalysts to produce lactic acid (LA) from the monosaccharides present in corn stover (glucose, xylose, and arabinose) resulting in ytterbium being the most active. A MW-heated system led to similar LA yield as a conventionally heated pressurized system. The maximum value of LA yield was 40% at 240 °C after 20 min of isothermal treatment regardless the starting monosaccharides, which allowed to propose a similar LA production route based on the products profile determined along time for the three monosaccharides. Temperature and time determined the product profile, observing furfural degradation at severity factors higher than 3.5, while values higher than 5.5 were needed to observe LA degradation. By increasing temperature, catalyst solubility decreased, increasing its presence in the solid residue after treatment. Xylan conversion to LA was similar as for xylose, but lower yield was obtained from microcrystalline cellulose. Corn stover presented more amorphous regions leading to higher hydrolysis yields of its cellulose fraction.
Testing for biofilm release as a function of simulated ship speed using a calibrated water jet device
Authors: Shepard Zachary , Meyer D. M. L. , Kurtz Kayla , Julien Asa , Oyanedel-Craver Vinka , Maranda Lucie
Published: May 2024

Biofouling release coatings (BRCs) have received attention for their potential to limit the negative impacts of biofouling on marine shipping. The calibrated water jet (CWJ, patent # US 8,984,958 B1) can be used to study the effectiveness of BRCs as a function of ship speed. Using a balance of force and linear momentum, we examined the theory and application of the CWJ for simulating the effect of ship speed on biofilm release for surfaces fouled under (1) laboratory and (2) natural conditions. Greater fouling release corresponded with an increase in CWJ pressure and, therefore, simulated ship speed for the surfaces coated with HullKote. The effectiveness of the CWJ was further confirmed for biofilm release from glass fouled naturally by submersion in flow-through seawater. A scaling analysis confirms that the results of these small-scale experiments are applicable to larger-scale biofouling release from ship hulls. This study is the first to utilize the pressure of a CWJ to quantify biofouling release as a function of simulated ship speed.
The Role of Fe, S, P, Ca, and Sr in Porous Skeletal Lesions: A Study on Non-adult Individuals Using pXRF
Authors: Gomes Ricardo A. M. P. , Catarino Lidia , Santos Ana Luisa
Published: May 2024

Portable X-ray fluorescence is a new tool in the study of human bone. This research aims to investigate if variations in bone elemental concentrations are related with porous skeletal lesions (PSLs). One hundred well-preserved non-adult skeletons aged 0–11 years were selected from the archaeological site Convent of São Domingos, Lisbon (18th–19th century). Measuring a standard reference material and calculating the technical error of measurement assured elemental data reliability. Moreover, measuring soil samples excluded possible contamination of bones with elements from the soil, except for Pb. Additionally, the Ca/P ratio indicates maintenance of bone integrity. Cribra cranii, orbitalia, humeralis, and femoralis were recorded as present/absent, and the estimated intra-/inter-observer errors were low. The multivariate analysis found higher odds of having cribra orbitalia (OR = 1.76; CI = 0.97–3.20) and cribra femoralis (OR = 1.42; CI = 0.73–2.74) in individuals with lower Fe and higher S. Furthermore, higher levels of P, Ca, and Sr increased the odds of individuals developing cribra femoralis (OR = 2.30; CI = 1.23–4.29). Age also correlated with increased odds of exhibiting cribra orbitalia (OR = 1.86; CI = 0.94–3.68), cribra femoralis (OR = 6.97; CI = 2.78–17.45), and cribra humeralis (OR = 8.32; CI = 2.71–25.60). These findings suggest a shared etiology for these three cribras, contrasting with the higher Fe levels in individuals with cribra cranii. Lower Fe and higher S levels in individuals with cribra suggest a complex etiology, possibly involving conditions like megaloblastic or chronic disease anemia(s). Age-related elemental changes support the hypothesis that age influences cribra frequencies. This study highlights PSL complexity and opens new avenues for research.
Commutators on Spaces of Homogeneous Type in Generalized Block Spaces
Authors: Dung Tran Tri , Dao Nguyen Anh , Duong Xuan Thinh , Nghia Le Trung
Published: May 2024

In this paper, we are interested in studying a generalized block space (denoted as $$\textbf{B}^{p,r}_\varphi $$

B
φ

p
,
r

) on a space of homogeneous type. We show that this space is the predual of certain generalized Morrey–Lorentz space. By duality, we obtain the $$\textbf{B}^{p,r}_\varphi $$

B
φ

p
,
r

-bound of operators of Calderón–Zygmund type. In addition, we prove a weak Hardy factorization in terms of commutators of integral operator of Calderón–Zygmund type in block spaces. Thanks to the Hardy factorization result, we obtain a characterization of functions in $$\textrm{BMO}$$
BMO
via the boundedness of commutators of homogeneous linear Calderón–Zygmund operators in the generalized block space (resp. the generalized Morrey–Lorentz space). Finally, we study a compactness characterization of commutators of Calderón–Zygmund type in generalized Morrey–Lorentz spaces.
Drug resistance in breast cancer is based on the mechanism of exocrine non-coding RNA
Authors: Ye Simin , Chen Shiyu , Yang Xiaoyan , Lei Xiaoyong
Published: May 2024

Breast cancer (BC) ranks first among female malignant tumors and involves hormonal changes and genetic as well as environmental risk factors. In recent years, with the improvement of medical treatment, a variety of therapeutic approaches for breast cancer have emerged and have strengthened to accommodate molecular diversity. However, the primary way to improve the effective treatment of breast cancer patients is to overcome treatment resistance. Recent studies have provided insights into the mechanisms of resistance to exosome effects in BC. Exosomes are membrane-bound vesicles secreted by both healthy and malignant cells that facilitate intercellular communication. Specifically, exosomes released by tumor cells transport their contents to recipient cells, altering their properties and promoting oncogenic components, ultimately resulting in drug resistance. As important coordinators, non-coding RNAs (ncRNAs) are involved in this process and are aberrantly expressed in various human cancers. Exosome-derived ncRNAs, including microRNAs (miRNAs), long-noncoding RNAs (lncRNAs), and circular RNAs (circRNAs), have emerged as crucial components in understanding drug resistance in breast cancer. This review provides insights into the mechanism of exosome-derived ncRNAs in breast cancer drug resistance, thereby suggesting new strategies for the treatment of BC.
The Effect of the Prior and the Experimental Design on the Inference of the Precision Matrix in Gaussian Chain Graph Models
Authors: Shen Yunyi , Solís-Lemus Claudia
Published: May 2024

Here, we investigate whether (and how) experimental design could aid in the estimation of the precision matrix in a Gaussian chain graph model, especially the interplay between the design, the effect of the experiment and prior knowledge about the effect. Estimation of the precision matrix is a fundamental task to infer biological graphical structures like microbial networks. We compare the marginal posterior precision of the precision matrix under four priors: flat, conjugate Normal-Wishart, Normal-MGIG and a general independent. Under the flat and conjugate priors, the Laplace-approximated posterior precision is not a function of the design matrix rendering useless any efforts to find an optimal experimental design to infer the precision matrix. In contrast, the Normal-MGIG and general independent priors do allow for the search of optimal experimental designs, yet there is a sharp upper bound on the information that can be extracted from a given experiment. We confirm our theoretical findings via a simulation study comparing (i) the KL divergence between prior and posterior and (ii) the Stein’s loss difference of MAPs between random and no experiment. Our findings provide practical advice for domain scientists conducting experiments to better infer the precision matrix as a representation of a biological network.
Bionic functional membranes for separation of oil-in-water emulsions
Authors: Chen Chaolang , Jiang Ruisong , Guo Zhiguang
Published: May 2024

The separation of oil-in-water emulsion is an urgent challenge because its massive production and discharge from daily and industrial activities have caused severe hazards to the ecosystem and serious threats to human health. Membrane technology is considered an outstanding solution strategy for the separation of oil-in-water emulsions due to its unique advantages of low cost, high efficiency, easy operation, and environmental friendliness. However, the membrane is easily fouled by the emulsion oil droplets during the separation process, causing a sharp decline in permeation flux, which greatly inhibits the long-term use of the membrane and largely shortens the membrane’s life. Recently, it was found that endowing the membranes with special wettability e.g., superhydrophilic and superoleophobic can greatly enhance the permeability of the continuous water phase and inhibit the adhesion of oil droplets, thus promoting the separation performance and anti-oil-fouling property of membrane for oily emulsions. In this paper, we review and discuss the recent developments in membranes with special wettability for separating oil-in-water emulsions, including the mechanism analysis of emulsion separation membrane, membrane fouling issues, design strategies, and representative studies for enhancing the membrane’s anti-oil-fouling ability and emulsion separation performance.
Core-rim structured MXene@SiO2 composites as oil-based additives for enhanced tribological properties
Authors: Cui Yuhong , Xue Shenghua , Wang Tiantian , Liu Shujuan , Ye Qian , Zhou Feng , Liu Weimin
Published: May 2024

Herein, we have prepared SiO2 particles uploaded MXene nanosheets via in-situ hydrolysis of tetraetholothosilicate. Due to the large number of groups at the edges of MXene, SiO2 grows at the edges first, forming MXene@SiO2 composites with a unique core-rim structure. The tribological properties of MXene@SiO2 as lubricating additive in 500 SN are evaluated by SRV-5. The results show that MXene@SiO2 can reduce the friction coefficient of 500 SN from 0.572 to 0.108, the wear volume is reduced by 73.7%, and the load capacity is increased to 800 N. The superior lubricity of MXene@SiO2 is attributed to the synergistic effect of MXene and SiO2. The rolling friction caused by SiO2 not only improves the bearing capacity but also increases the interlayer distance of MXene, avoiding accumulation and making it more prone to interlayer slip. MXene@SiO2 is adsorbed on the friction interface to form a physical adsorption film and isolate the friction pair. In addition, the high temperature and high load induce the tribochemical reaction and form a chemical protection film during in the friction process. Ultimately, the presence of these protective films results in MXene@SiO2 having good lubricating properties.
Integrity games: an online teaching tool on academic integrity for undergraduate students
Authors: Goddiksen Mads Paludan , Allard Aurélien , Armond Anna Catharina Vieira , Clavien Christine , Loor Hillar , Schöpfer Céline , Varga Orsolya , Johansen Mikkel Willum
Published: May 2024

In this paper, we introduce Integrity Games (https://integgame.eu/) – a freely available, gamified online teaching tool on academic integrity. In addition, we present results from a randomized controlled experiment measuring the learning outcomes from playing Integrity Games.

Integrity Games engages students in reflections on realistic and relevant academic integrity issues that lie in the grey zone between good practice and misconduct. Thereby, it aims to 1) motivate students to learn more about academic integrity, 2) increase their awareness of the grey-zone issues, and 3) increase their awareness of misconduct. To achieve these aims, the tool presents four gamified cases that lead students through an engaging narrative.

The experiment to measure learning outcomes was conducted in three European countries, and included N = 257 participants from across natural science, social science and the humanities. We show that the participants enjoyed playing Integrity Games, and that it increased their sensitivity to grey-zone issues and misconduct. However, the increases identified were similar to those achieved by the participants in the control group reading a non-gamified text.

We end by discussing the value of gamification in online academic integrity training in light of these results.
Quantifying the relative importance of biotic and abiotic factors in landscape-based models of stream fish distributions
Authors: Custer Christopher A. , Fischer Douglas P. , Smith Geoffrey , Henning Aaron , Schall Megan Kepler , Shank Matthew K. , Wertz Timothy A. , Wagner Tyler
Published: May 2024

Lotic fish species distributions are frequently predicted using remotely sensed habitat variables that characterize the adjacent landscape and serve as proxies for instream habitat. Recent advancements in statistical methodology, however, allow for leveraging fish assemblage data when predicting distributions. This is important because assemblage composition likely provides better information about instream habitat compared to landscape-derived metrics and therefore may improve predictions. To better understand the value of using multi-species fish data in species distribution modeling, we fit two conditional random fields (CRF) models to quantify the relative importance of fish assemblage co-occurrence, landscape-derived habitat variables, and interactions between these two predictor groups (i.e., effects of co-occurrence could be context-dependent) at over 1200 stream catchments in Pennsylvania, USA. We first compared predictive performance of CRF models against traditionally used single-species logistic regressions (generalized linear models; GLMs) and found that inclusion of fish assemblage data often improved predictive performance. The multi-species CRF models performed significantly better at predicting occurrence for 63% of species with an average percent increase in AUC of 25% compared to GLMs. Furthermore, the CRF identified species co-occurrences as more informative, and thus relatively more important, at predicting occurrence than the other effect types. The CRF also suggested that allowing these biotic effects to be context-dependent was important for predicting occurrence of many species. These findings illustrate the value of fish assemblage data for landscape-scale species distribution modeling and leveraging this information can improve predictions and inferences to help inform the management and conservation of freshwater fishes.
Correlation between Serum Levels of Nitric Oxide and Adropin and Erectile Dysfunction in Males with Nonalcoholic Fatty Liver Disease: An Observational Study
Authors: Ragab Ahmed , Fattah Ali M Abdel , Sayed Ahmed Reda , GamalEl Din Sameh Fayek , Mahmoud Hassan Shrouk Matrawy , Mohamed Aya Yaseen Mohamed , Hamed Mostafa Ahmed
Published: May 2024

The current study aimed to evaluate the serum levels of nitric oxide (NO) and adropin in males with non-alcoholic fatty liver disease (NAFLD) induced erectile dysfunction (ED) and NAFLD patients without ED and controls. The current study selected 165 participants from the hepatology department from November 2021 to November 2022. The patients were either suffering from NAFLD with normal liver functions or non-alcoholic steatohepatitis with abnormal liver functions. They were diagnosed by abdominal ultrasonography. Participants were evaluated using the validated Arabic version of the International Index of Erectile Function (ArIIEF-5), the Arabic form of the Generalized Anxiety Disorder-7 (GAD-7) questionnaire and the Patient Health Questionnaire-9 (PHQ-9). Noteworthy, there were significant positive correlations between ArIIEF-5 score, NO, adropin and total testosterone (r = 0.380, p = 0.001; r = 0.507, p =  < 0.001; r = 0.246, p = 0.038, respectively). Meanwhile, there were significant negative correlations between ArIIEF-5 score, creatinine, duration of the disease and scores of GAD-7 and PHQ-9 (r = -0.656, p =  < 0.001; r = -0.368, p = 0.002; r = -0.663, p =  < 0.001; r = -0.248, p = 0.037, respectively). Finally, a linear regression analysis revealed that GAD-7, creatinine, and adropin were the only strong independent predictors of ArIIEF-5, as the 95% confidence interval in the form of upper and lower bounds was -0.349, -0.843, p < 0.001, -6.507, -18.402, p < 0.001, 0.476, 0.117, and p 0.002, respectively. Impaired NO and adropin levels play a potential role in the development of ED in patients with NAFLD.
Knowledge and God
Authors: Benton Matthew A.
Published: May 2024

This Element examines a main theme in religious epistemology, namely, the possibility of knowledge of God. Most often philosophers consider the rationality or justification of propositional belief about God, particularly beliefs about the existence and nature of God; and they will assess the conditions under which, if there is a God, such propositional beliefs would be knowledge, particularly in light of counter-evidence or the availability of religious disagreement. This Element surveys such familiar areas, then turns toward newer and less-developed terrain: interpersonal epistemology, namely what it is to know another person. It then explores the prospects for understanding what it might take to know God relationally, the contours of which are significant for many theistic traditions.
Costly Opportunities
Authors: Álvarez-Rivadulla María José
Published: May 2024

This Element investigates entrenched inequality in Latin America through a unique case of class integration in Colombian higher education. Examining a forgivable loan program benefiting 40,000 high-achieving individuals from disadvantaged backgrounds, the Element introduces 'gate opening' and 'diversified networks' as mechanisms countering traditional inequality reproduction. Utilizing a longitudinal, ethnographic approach, it explores the evolving process of social mobility within an elite school, emphasizing subjective experiences and challenges. Despite educational gaps and stark social differences, most students formed cross-class friendships, completed their education, and achieved higher socioeconomic positions. Yet, in so doing they had to face several costs of social mobility resourcing to strategies such as camouflaging or disclosing, sometimes becoming culturally omnivourous in the end. The significance of a prestigious degree varies based on the professional labor market, with first-generation students facing more challenges in low quality or elitist markets where cultural and social capital act as entry barriers.