bluuebunny/crossref_metadata_2025 huggingface dataset:
Nintedanib induces apoptosis in human pterygium cells through the FGFR2-ERK signalling pathway
Authors:   Ningbo Eye Hospital, Ningbo 315042, Zhejiang Province, China, Gong Yan , Yi Quan-Yong ,   Ningbo Eye Hospital, Ningbo 315042, Zhejiang Province, China, Li Meng ,   Health Science Center, Ningbo University, Ningbo 315021, Zhejiang Province, China, Chen Li-Shuang ,   Ningbo Eye Hospital, Ningbo 315042, Zhejiang Province, China, Wang Yan-Yan ,   Ningbo Eye Hospital, Ningbo 315042, Zhejiang Province, China
Published: April 2023

AIM: To investigate whether nintedanib can inhibit pterygium cells through the fibroblast growth factor receptor 2 (FGFR2)/extracellular-signal-regulated kinase (ERK) pathway.
METHODS: Human primary pterygium cells were cultured in vitro. After treatment with nintedanib, the cell morphology was observed under microscopy, the morphological changes of the nucleus were observed after DAPI staining, apoptosis was analyzed by Annexin-V FITC/PI double staining, and the changes of apoptosis-associated proteins were detected by Western blot. The binding ability of nintedanib to FGFR2 was predicted by molecular docking. Finally, by silencing FGFR2, we explored whether nintedanib inhibited FGFR2/ERK pathway.
RESULTS: The results showed that nintedanib inhibited the growth of pterygium cells and caused nuclear pyknosis. The results of Annexin-VFITC/PI double staining showed that nintedanib was able to induce early and late apoptosis of pterygium cells, significantly increasing the expression of apoptosis-associated proteins Bax and cleaved-Caspase3 (P<0.05), and reducing the expression of Bcl-2 (P<0.05). In addition, nintedanib significantly inhibited ERK1/2 phosphorylation through FGFR2 (P<0.05). After silencing the expression of FGFR2, there was no significant difference in the inhibition of ERK1/2 phosphorylation by nintedanib (P>0.05).
CONCLUSION: Nintedanib induces apoptosis of pterygium cells by inhibiting FGFR2/ERK pathway.
Role of apigenin in high glucose-induced retinal microvascular endothelial cell dysfunction via regulating NOX4/p38 MAPK pathway in vitro
Authors:   Department of Ophthalmology, Liuzhou Workers’ Hospital, the Fourth Affiliated Hospital of Guangxi Medical University, Liuzhou 545005, Guangxi Zhuang Autonomous Region, China, Liu Li-Li
Published: April 2023

AIM: To investigate the retinoprotective role of Apigenin (Api) against high glucose (HG)-induced human retinal microvascular endothelial cells (HRMECs), and to explore its regulatory mechanism.
METHODS: HRMECs were stimulated by HG for 48h to establish the in vitro cell model. Different concentrations of Api (2.5, 5, and 10 μmol/L) were applied for treatment. Cell counting kit-8 (CCK-8), Transwell, and tube formation assays were performed to examine the effects of Api on the viability, migration, and angiogenesis in HG-induced HRMECs. Vascular permeability was evaluated by Evans blue dye. The inflammatory cytokines and oxidative stress-related factors were measured using their commercial kits. Protein expression of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase 4 (NOX4) and p38 mitogen-activated protein kinase (MAPK) was measured by Western blot.
RESULTS: Api prevented HG-induced HRMECs viability, migration, angiogenesis, and vascular permeability in a concentration-dependent manner. Meanwhile, Api also concentration-dependently inhibited inflammation and oxidative stress in HRMECs exposed to HG. In addition, HG caused an elevated expression of NOX4, which was retarded by Api treatment. HG stimulation facilitated the activation of p38 MAPK signaling in HRMECs, and Api could weaken this activation partly via downregulating NOX4 expression. Furthermore, overexpression of NOX4 or activation of p38 MAPK signaling greatly weakened the protective role of Api against HG-stimulated HRMECs.
CONCLUSION: Api might exert a beneficial role in HG-stimulated HRMECs through regulating NOX4/p38 MAPK pathway.
A 3-month comparison study of subjective and objective visual quality of small incision lenticule extraction and transepithelial photorefractive keratectomy in patients with low and moderate myopia
Authors:   Department of Ophthalmology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China, Wang Li-Xiang , Tang Jing ,   Department of Ophthalmology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China, Ma Ke ,   Department of Ophthalmology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China, Yin Hong-Bo ,   Department of Ophthalmology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China, Deng Ying-Ping ,   Department of Ophthalmology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
Published: April 2023

AIM: To compare the subjective and objective visual quality between small incision lenticule extraction (SMILE) and transepithelial photorefractive keratectomy (tPRK) in patients with low and moderate myopia.
METHODS: Patients undertaking SMILE or tPRK for the correction of low and moderate myopia were consecutively recruited in this prospective cohort study with a 3-month follow-up period. Objective evaluation [visual acuity test, manifest refraction, wavefront aberrations, the total cut-off value of the total modulation transfer function (MTFcut-off), and Strehl ratio (SR)] and subjective evaluation of visual quality (quality-of-life questionnaire) were conducted before surgery and at days 1, 7, 30, and 90 after surgery.
RESULTS: A total of 47 patients (94 eyes) with SMILE and 22 patients (22 eyes) with tPRK were enrolled. The uncorrected visual acuity (UCVA) was better in SMILE patients on day 7 after surgery (1.13±0.13 vs 0.99±0.17, t=4.85, P<0.001) but was comparable at days 30 and 90. At day 90, the SMILE group had a lower spherical equivalent (SE) than the tPRK group (0.04±0.31 vs 0.19±0.43, t=2.08, P=0.042). Total higher order aberrations (HOAs) were induced in both surgical types, which were more evident in the tPRK group with 3-mm pupil diameter (0.16±0.07 vs 0.11±0.05, t=4.27, P<0.001) and 5-mm pupil diameter (0.39±0.17 vs 0.36±0.11, t=2.33, P=0.022). The MTFcut-off and SR showed a trend of improvement in both SMILE and tPRK patients but were statistically better in the SMILE group with both pupil diameters. There was a significant improvement of contrast sensitivity (CS) over baseline levels at the spatial frequency of 18 cycles/degree (c/d) in the SMILE group (F=2.72, P=0.033) and at 3 c/d (F=3.03, P=0.031), 12 c/d (F=3.72, P=0.013), and 18 c/d (F=4.62, P=0.004) in the tPRK group. The subjective quality of life questionnaire showed a steady improvement in the SMILE group (F=8.31, P<0.001) but not the tPRK group.
CONCLUSION: SMILE and tPRK are both safe and effective ways to correct low and moderate myopia. A generally better and quicker recovery of visual quality favors the application of SMILE in qualified patients.
Receded near point of convergence as a predictor of mild cognitive impairment in the general geriatric population: results from a population-based study
Authors:   Rehabilitation Research Center, Department of Optometry, School of Rehabilitation Sciences, Iran University of Medical Sciences, Tehran 1449614535, Iran, Doostdar Asgar , Nabovati Payam ,   Rehabilitation Research Center, Department of Optometry, School of Rehabilitation Sciences, Iran University of Medical Sciences, Tehran 1449614535, Iran, Asharlous Amir ,   Rehabilitation Research Center, Department of Optometry, School of Rehabilitation Sciences, Iran University of Medical Sciences, Tehran 1449614535, Iran, Khabazkhoob Mehdi ,   Department of Basic Sciences, School of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran 1968653111, Iran
Published: April 2023

AIM: To investigate the relationship between near point of convergence (NPC) and mild cognitive impairment (MCI) in the general elderly population.
METHODS: The present report is a part of the Tehran Geriatric Eye Study (TGES): a population-based cross-sectional study conducted on individuals 60 years of age and above living in Tehran, Iran using the multi-stage stratified random cluster sampling method. Cognitive status was assessed using the Persian version of the Mini-Mental State Examination (MMSE). All study participants underwent complete ocular examination including measurement of uncorrected and best-corrected visual acuity, objective and subjective refraction, cover testing, NPC measurement, and slit-lamp biomicroscopy.
RESULTS: The data of 1190 individuals were analyzed for this report. The mean age of the participants analyzed was 66.82±5.42 (60-92y) and 728 (61.2%) of them were female. Patients with MCI had a significantly more receded NPC compared to subjects with normal cognitive status (10.89±3.58 vs 7.76±2.71 cm, P<0.001). In the multivariable logistic regression model and in the presence of confounding variables, a receded NPC was statistically significantly associated with an increased risk of MCI (odds ratio: 1.334, 95% confidence interval: 1.263 to 1.410, P<0.001). According to receiver operating characteristic (ROC) analysis, a cut point NPC> 8.5 cm (area under the curve: 0.764, P<0.001) could predict the presence of MCI with a sensitivity and specificity of 70.9% and 69.5%, respectively.
CONCLUSION: A receded NPC can be clinically proposed as a predictor of MCI in older adults. It is recommended that elderly with a receded NPC>8.50 cm undergo detailed cognitive screening for a definite diagnosis of MCI. In this case, the necessary interventions can be carried out to slow down MCI progression to dementia.
Perilaku Konsumen Kopi: Proses Keputusan dan Kepuasan Konsumen Membeli Minuman Kopi Berlabel Fair Trade
Authors: Sihombing Vista Uli , Fariyanti Anna , Pambudy Rachmat
Published: April 2023

Fair Trade (FT) coffee has a higher production volume than other coffee certifications. This phenomenon is triggered by a shift that is influenced consumer behavior patterns. This study analyzes consumer characteristics, purchasing decisions, and satisfaction in buying FT coffee. A cross-sectional study with a quantitative approach was used as the research design. Data were obtained by distributing online questionnaires to 120 respondents using a voluntary sampling technique. Data were analyzed using descriptive analysis, Customer Satisfaction Index (CSI), and Importance Performance Analysis (IPA). The results showed that most respondents were male, with an undergraduate degree and unmarried status. Trends and easy to get drink influence the main reason for purchasing. The main source of information comes from friends who focus on the coffee's taste and flavor. Consumers will continue to buy coffee even though prices have increased. Through CSI calculation, customer satisfaction is worth 74.04%. The results of the IPA calculation show that the main attributes to be improved are price, sales location, and information provision. The results of this study can be used as information on developing a marketing strategy that is adjusted to evaluate consumer expectations.

 

Keywords: characteristics, consumer behavior, fair trade coffee, purchasing decision, satisfaction
C/SiC-based anodes for lithium-ion current sources
Authors:   Ural Federal University, Leonova Natalia M. , Leonova Anastasia M. ,   Ural Federal University, Bashirov Oleg A. ,   Ural Federal University, Lebedev Alexey S. ,   Institute of Mineralogy – a division of the the South Urals Federal Research Center of Mineralogy and Geo-ecology of the Urals Branch of the Russian Academy of Sciences, Trofimov Alexey A. ,   Ural Federal University, Suzdaltsev Andrey V. ,   Ural Federal University
Published: April 2023

Compositions of ultrafine Si and C particles are promising anode materials for lithium-ion power sources with improved energy characteristics. In the work, samples of lithium-ion power sources with an anode made of ultrafine SiC fibers, as well as mixtures of SiC fibers with graphite (C/SiC) and electrolytically deposited submicron silicon fibers (C/Si/SiC) were fabricated and studied for energy characteristics. The working ability of the mixtures obtained during lithiation/delithiation was shown, and the main energy characteristics of the investigated anode half-cells were determined. After 100 cycles, the SiC anode reached a discharge capacity of 180 and 138 mA·h/g at a charge current of C/20 and C, respectively. Anodes made of mixtures (wt%) 29.5C-70.5SiC and 50Si-14.5C-35.5SiC show discharge capacities of 328 and 400 mA·h/g at a charge current of C/2. The Coulomb efficiency of all samples was above 99%.
НЕФОРМАЛЬНЫЕ ТРУДОВЫЕ ПРАКТИКИ СЕЛЬСКОГО НАСЕЛЕНИЯ (НА ПРИМЕРЕ ХАКАСИИ)
Authors: Лушникова Ольга Леонидовна
Published: April 2023

Социально-экономическая ситуация в сельской местности, связанная с безработицей, меняет трудовое поведение сельского населения. Особенно в непростом положении находится население отдаленных территорий, возможности которого существенно ограничены. Жители таких поселений вынуждены искать разные способы заработка в месте своего проживания и чаще находят их в неформальном секторе экономики. Однако неформальная занятость носит преимущественно случайный характер, не обеспечивает социальных гарантий и является низкооплачиваемой, что провоцирует рост бедности и приводит к обострению социальных противоречий на селе. Цель работы – выявление практик неформальной занятости и их влияние на материальное благополучие сельских жителей, проживающих вдали от районных или городских центров (исследование проводилось в Республике Хакасия). Методы: эмпирической базой для исследования послужили данные социологического опроса 2022 г. среди жителей удаленных сел Хакасии. Опрашивалось население больших (от 500 до 1000 чел.) и малых (до 500 чел.) сел. Объем окончательной выборки составил 404 чел. Использовались также результаты интервью (33 чел.). Результаты: жители удаленных сельских территорий достаточно активны в плане вторичной занятости, хотя она чаще носит вынужденный характер. Дополнительная занятость часто официально не оформляется, либо оформляется на неполную ставку, хотя объем работы соответствует полной ставке, и, как правило, не приносит ощутимого дохода. Наиболее распространенной практикой неформальной занятости на селе являются случайные заработки, причем сельские жители занимаются как традиционными, так и нетрадиционными видами деятельности. В больших селах дополнительная занятость положительно сказывается на улучшении материального благополучия сельчан, а в малых селах этому больше способствует ведение личного подсобного хозяйства, в частности разведение скота.
Algumas considerações sobre o uso do báculo (baculum) na Elaboração de atividades que articulam história e ensino de matemática
Authors: Miranda Castillo Ana Rebeca
Published: April 2023

En este artículo presentamos algunas consideraciones acerca de un instrumento matemático, ampliamente utilizado en el siglo XVI, con miras a explorar posibles recursos didácticos. Basados ​​en el tratado Del modo di misurare, publicado por Cosimo Bartoli (1503-1572) en 1564, presentamos dos procedimientos de medición utilizando el báculo (báculo). Además de las cuestiones relacionadas con el conocimiento matemático involucrado en el instrumento y los procedimientos de medición, los dos casos de uso del instrumento apuntaron cuestiones interesantes no solo matemáticas, sino también epistemológicas, en la articulación entre el conocimiento teórico y práctico.
Reconstruyendo el paradigma verbal quechua : el caso de la transición de primera a segunda persona
Authors: Adelaar Willem F.H.
Published: April 2023

En el presente artículo, dedicado al trabajo de nuestro distinguido colega Cerrón-Palomino, resulta oportuno escoger un tema perteneciente a la reconstrucción del paradigma verbal de referencia personal quechua. De hecho, al lado de los sufijos que indican sujetos de primera y segunda persona, y cuya evolución histórica ha generado una discusión científica intensa, existe otra marca de referencia personal cuya reconstrucción histórica sigue desafiando a los lingüistas. Se trata del elemento que tiene por función la de marcar la combinación de un actor de primera persona con un objeto de segunda persona (en adelante IS> 20) en varios contextos. En la mayor parte de los dialectos quechuas, sobretodo en las variedades más conservadoras, este elemento aparece como un sufijo portmanteau que toma formas distintas, -yki, -q, -k, según la variedad dialectal. La distribución geográfica de las formas referidas se tratará en la sección 3. Resalta la inestabilidad formal del sufijo respectivo, que parece haber tenido dificultades en mantenerse a lo largo de la historia evolutiva del quechua. Por otro lado, para marcar la misma combinación en el tiempo futuro del modo indicativo, la mayoría de los dialectos quechuas maneja una forma especial, -sh(q)ayki (~ -s(q)ayki), que ella sí muestra una alta homogeneidad a través de las distintas variedades dialectales.
Rastros desconcertantes de contactos entre idiomas y culturas a lo largo de los contrafuertes orientales de los Andes del Perú
Authors: Wise S. Mary Ruth.
Published: April 2023

Los idiomas hablados a lo largo de los contrafuertes andinos del Perú pertenecen a, por lo menos, cuatro familias de lenguas. Pero exhiben muchos puntos desconcertantes de similitud, que podrían ser considerados como rastros posibles de contacto prolongado entre los hablantes de esos idiomas.
La idea è buona, ma no te ha salido ...
Authors: Crousse de Vallonge Rastelli Verónica
Published: April 2023

Anna era maestra. Tenía el convencimiento de que no basta transmitir conocimientos, sino que hay que actuar sobre el espíritu del alumno. El convencimiento de que la enseñanza es un trabajo largo, de ida y vuelta, por el que a través de la práctica de la escultura se moldea y tiempla la personalidad del alumno, y esta personalidad trabajada con paciencia y rigor, día a día, pasito a paso, será la base indispensable para que el alumno se pueda convertir en un buen artista.
Aproximaciones a la escultura de Jorge Piqueras
Authors: Trivelli Carlo
Published: April 2023

Si uno cree en el destino, es inevitable pensar que Jorge Piqueras estaba destinado al arte. No sólo es hijo del escultor español Manuel Piqueras Cotolí sino que Jorge nació en el local mismo de la Escuela de Bellas Artes, donde su padre se alojaba cuando llegó al Perú para dirigirla a mediados de los años veinte . Si uno no cree en el destino, el hecho de que abandonara los estudios de arquitectura y se matriculara en la Escuela de Bellas Artes de la Universidad Católica y, tras hacer su aprendizaje bajo la guía de Adolfo Winternitz, ganara el Premio de Escultura «Baltazar Gavilán» cuando contaba apenas con veintidós años, debería ser suficiente como para aceptar que Jorge Piqueras estaba convocado a ser artista.
(Un)Acknowledgment of Men as Victims of Intimate Partner Violence
Authors: Machado Andreia , Santos Anita , Matos Marlene
Published: April 2023

Some victims of interpersonal violence do not acknowledge or label their experience as criminal. This study aims to explore men’s experiences as victims of intimate partner violence and identify the key elements that contribute to their (un)acknowledgment and needs. We interviewed 10 Portuguese male victims in heterosexual relationships who requested formal help. A thematic analysis was performed using NVivo 11. Social gender discourses and expectations prevented men from acknowledging their intimate victimization and created barriers to seeking help. Participants struggled to achieve the social status of the victim and to gain access to intervention measures. These findings reflect the invisibility and insufficient social awareness of intimate partner violence against men and enhance our understanding of the need of those men.
O uso criativo dos objetos
Authors: Machado Marina Marcondes
Published: April 2023

Este artigo parte da experiência biográfica da autora junto ao grupo de teatro Ventoforte, na década de 1980, de modo a explicitar pressupostos estéticos e artístico-pedagógicos do encenador Ilo Krugli (1930-2019). A autora associa o trabalho com objetos animados e a direção de atores de Ilo com a teoria do espaço potencial de D. W. Winnicott (2019), habitando um entrelugar: dualidade entre tradição e inovação no chamado “teatro para todas as idades”.
Tarsila ou a vacina antropofágica
Authors: Dias Viviane Costa , Martins Ferdinando
Published: April 2023

Trata-se de um texto teatral de voz feminista, um diálogo ético e estético com o Modernismo brasileiro na busca de novas imagens para a reinvenção de um país. O texto foi encenado em São Paulo em setembro e outubro de 2022. E segue para Paris, em novembro; E Lisboa, em dezembro do memso ano. Tarsila, um corpo-assentamento do Modernismo brasileiro acorda no cosmos, em 2022. Precisa criar uma nova imagem antes de ser devorada pela voracidade do novo Piaimã.
Avaliação dos Centros de Atenção Psicossocial: Uma Revisão Integrativa
Authors: Costa Icaro , Melo Cynthia de Freitas
Published: April 2023

Introdução: O Centro de Atenção Psicossocial (CAPS) é um serviço orientado pelos princípios de reforma psiquiátrica, o qual oferece atendimento às pessoas com transtornos mentais ou problemas relacionados ao uso de álcool/drogas e necessita de constante avaliação. Objetivou-se analisar a produção científica acerca das condições de trabalho e da qualidade do serviço prestado nos CAPS. Método: Realizou-se uma revisão integrativa da literatura, selecionando artigos publicados no SciELO, BVS-Saúde e PubMed, por meio de critérios predefinidos. Resultados: Analisaram-se 34 artigos. Prevaleceram estudos publicados em revistas de saúde coletiva, retratando pesquisas qualitativas. Sinalizam a qualidade do serviço do CAPS, seu potencial de inclusão social dos usuários, deficits na operacionalização de algumas práticas da reforma psiquiátrica (ações de território, redução de danos, apoio matricial), problemas interpessoais entre profissionais e gestores, falta de recursos materiais e fragilidade de vínculo empregatício dos profissionais. Discussão: Apesar da longa luta antimanicomial, existem problemas orçamentários, estruturais e na formação e comunicação entre profissionais que comprometem a assistência em saúde mental. Conclusão: O CAPS é um serviço essencial aos usuários, porém possui problemas operacionais, especialmente no atendimento, condições de trabalho e vínculo entre redes assistenciais, exigindo reorganização do serviço e capacitação profissional.
Violência Sexual contra Crianças e Adolescentes: Teoria Implícita
Authors: Guedes Barbosa (in memoriam) Gabriel , Tavares Andrea Schettino , Nogueira Raiane Nunes , Costa Liana Fortunato
Published: April 2023

O objetivo deste texto é identificar as teorias implícitas sobre a masculinidade e a vítima criança/adolescente, nos conteúdos de falas de homens adultos autores de ofensa sexual. Na violência sexual, o indivíduo que ofende supõe propriedades de suas vítimas a partir de suas próprias representações mentais. Trata-se de pesquisa documental realizada em uma instituição de atenção ao adulto ofensor sexual, com base no registro de duas intervenções grupais ocorridas em 2018 e 2019. Os resultados foram organizados e discutidos em sentidos que deram ênfase: na expressão da masculinidade, na relação com a mulher e com a criança/adolescente. Buscou-se dar visibilidade à construção das crenças e imposições de pensamento que são produzidas na vida social e familiar e que dão maior poder e dominação ao homem. Estes sentidos apontados indicam o gênero masculino como centro das relações e o gênero feminino submetido e dominado.
Influência de Fatores Psicológicos e Sociais nos Comportamentos Preventivos de Saúde dos Homens
Authors: Falcão-Lima Giulia Oliveira , Silva-Santos Luana Cristina , Faro André
Published: April 2023

Introdução: Homens tendem a retardar a procura por serviços de saúde e têm baixa adesão a tratamentos, causando piores indicadores de saúde. Objetivou-se analisar a influência de fatores psicológicos e sociais nos comportamentos preventivos de saúde adotados por homens. Métodos: Utilizaram-se um questionário sociodemográfico, o Inventário de Conformidade com Normas Masculinas (CMNI), o Self-Reporting Questionnaire (SRQ) e o Questionário de Atitudes e Comportamentos de Saúde (QACS). Participaram da análise 315 homens adultos de todo o Brasil. Resultados: Uma regressão linear revelou que eram preditores de menor prevenção: pontuar alto em traços que indicavam desejo por admiração e respeito e comportamentos sexuais arriscados, bem como a maior probabilidade de presença de transtorno mental, ter cor de pele preta e menor nível educacional. Discussão: Foram mapeados fatores de risco para a menor conduta preventiva em homens. Conclusão: Conclui-se que variáveis psicológicas e sociais exercem forte influência sobre os comportamentos de saúde dos homens, sendo necessárias ações de promoção da saúde masculina para além das políticas públicas existentes, na busca pela elaboração de novas ações focadas neste grupo e temática específicos.
Estresse em Mães com Filhos Diagnosticados com Autismo
Authors: Tinoco Verônica Cristina , Dornela Tassiana Tezolini , Castro Gisélia Gonçalves de , Peres Tacyana Silva
Published: April 2023

Introdução: Responsabilizar-se por uma criança com algum transtorno crônico apresenta alterações na qualidade de vida da família. O objetivo desta pesquisa é identificar sintomas de estresse em cuidadores de crianças com transtorno do espectro autista (TEA) e verificar a prevalência das fases de estresse manifestadas. Material e Métodos: A partir da abordagem quantitativa, utilizou-se o Inventário de Sintomas de Stress para Adultos de Lipp (ISSL). Resultados e Discussão: O estudo foi realizado em uma cidade no interior de Minas Gerais. Participaram 77 famílias de indivíduos com autismo, representadas pelo familiar mais envolvido com os cuidados do filho. A mãe é quem está em tempo integral cuidando do filho, sofrendo mais impactos psicossociais. Conclusão: Seria adequado criar estratégias de intervenção e proporcionar às cuidadoras um ambiente que elas possam ser ouvidas. Assim, previne-se o agravamento do quadro do estresse materno, viabilizando a queda dos níveis de estresse, beneficiando o ambiente familiar.
Saúde Mental de Homens Gays na Pandemia
Authors: Belarmino Victor , Dimenstein Magda , Leite Jáder Ferreira
Published: April 2023

Vulnerabilidades prévias e sofrimentos crônicos relativos a preconceito, homofobia e discriminação marcam o cotidiano de gays. Tais vulnerabilidades e sofrimentos ganham novos contornos perante as restrições sanitárias impostas pela pandemia da covid-19. Objetivando compreender os fatores de vulnerabilização e adoecimento mental entre gays, realizou-se em 2020 uma pesquisa, do tipo exploratória, junto a 43 homens gays, com utilização de questionário eletrônico, da ferramenta Self-Reporting Questionnaire (SRQ-20) e realização de entrevistas com roteiro semiestruturado, junto a 8 participantes. Encontrou-se o percentual elevado de 60,5% no indicativo de Transtornos Mentais Comuns (TMC) entre os respondentes. Os dados indicam que os TMC se associam a marcadores sociais como raça, renda, escolaridade, bem como moradia, desigualdades no acesso e circulação na cidade e, particularmente, ser gay afeminado. As restrições sanitárias impuseram a intensificação de relações familiares conservadoras e heteronormativas e a diminuição da mobilidade, afastamento dos laços comunitários e de sociabilidade gay, agravando o estado de saúde mental.
Analysis of the Establishment of the Regional Technical Implementation Unit for the Animal Health Center (UPTD Puskeswan) for the Food Crops, Horticulture and Livestock Service Office in Mamuju Regency
Authors: Ma'ruf Muchammad Achsinul Fikri , Al-Arif Mohammad Anam , Lokapirnasari Widya Paramita , Hidanah Sri
Published: April 2023

The purpose of this study was a strategy in designing the establishment of the Regional Technical Implementation Unit for Animal Health Centers (UPTD Puskeswan) in order to optimize animal health services in Mamuju Regency. This study used an exploratory method using a survey. The sampling technique in this study used questionnaires, documentation and interviews. There were 10 samples of respondents from animal health workers and 100 samples of service users. Data analysis in this study used SWOT analysis. The appropriate strategy to support animal health services is a rapid growth strategy with alternative strategies: (1) strength-opportunity (SO) to improve service quality, service quantity and support the operational needs of officers in carrying out activities; (2) strength-threat (ST) implementing service SOP for animal health officers so that services are more efficient and systematic; (3) weakness-opportunity (WO) socialization of services to facilitate information to the public; and (4) weakness-threat (WT) making long-term planning to improve work ethic and understanding of drug use by veterinary officers.
The Quality of Japanese Quail Eggs After Administration of Bifidobacterium sp. and Guazuma ulmifolia Leaf Extract
Authors: Lovela Aprinda Ratna , Lokapirnasari Widya Paramita , Al-Arif Mohammad Anam , Soeharsono Soeharsono , Hidanah Sri , Warsito Sunaryo Hadi , Prasinta Redilla , Hapsari Tiara , Andriani Asafarid
Published: April 2023

This study aimed to determine the effect of Bifidobacterium sp. and Guazuma ulmifolia leaf extract on Japanese quail egg production, including egg mass, haugh unit (HU), and egg yolk colour. A total of 96 quails were in the early stages of production, which were randomized into four treatments and six replications. The treatments were (T0) without Bifidobacterium sp. and G. ulmifolia leaf extract, (T1) 0.2% Bifidobacterium sp., (T2) 0.2% G. ulmifolia leaf extract, and (T3) 0.2% Bifidobacterium sp. + 0.2% G. ulmifolia leaf extract. Egg mass data was collected in the third and fourth week of the treatment period, while the HU data and egg yolk colour were carried out on the last week of the treatment period. The treatment groups showed significant differences in egg mass. Groups T2 and T3 showed significant differences in egg yolk colour. The combination of feed additives can increase the value of HU but not significantly (p>0.05). In conclusion, the combination of 0.2% Bifidobacterium sp. and 0.2% G. ulmifolia leaf extract in drinking water can produce the highest egg quality.
Risk Factors and Incidence of Feline Lower Urinary Tract Disease (FLUTD) in Sahabat Satwa Genteng Animal Clinic
Authors: Novitasari Seline Putri , Arimbi Arimbi , Yunita Maya Nurwartanti , Hamid Iwan Sahrial , Wibawati Prima Ayu
Published: April 2023

The purpose of this study was to determine the risk factors and incidence of Feline Lower Urinary Tract Disease (FLUTD) at the Sahabat Satwa Genteng clinic. A total of 36 samples were evaluated according to research procedures with diagnosis, data collection, urine sampling, dipstick and sediment examination methods, and Chi-square data analysis. The results showed that there was a association between gender, history of castration, and diet on the risk of FLUTD. Meanwhile, there was no association between age and the risk of FLUTD. Clinical signs that often occur in FLUTD disease initiate from stranguria, hematuria, dysuria, periuria, and polykisuria. The results of the dipstick examination founded that 86,1% of cats affected by FLUTD had a normal pH and 13,9% had an alkaline pH. The results of the specific gravity (SG) of cats with FLUTD have values below normal while the protein levels found in all cats suffering from FLUTD have values above normal. Stranguria was found in 69,4% of cats with FLUTD. Leukocytes were also found in all the urine of cats suffering from FLUTD. The most common results of sediment examination were struvite, calcium oxalate, and cystine crystals.
An Evaluation of Draminski Detector as an Early Detection Tool for Subclinical Mastitis in Dairy Cattle in Pondok Ranggon Farm
Authors: Pisestyani Herwin , Permana Indra , Basri Chaerul , Lukman Denny Widaya , Sudarwanto Mirnawati
Published: April 2023

Subclinical mastitis is one of the main problems in the development of dairy farming in Indonesia. Several screening test tools have been developed to support of control program for this problem. This study aimed to assess the suitability of the Draminski detector as a screening tool for subclinical mastitis in dairy cows. Quaternary milk samples from 27 dairy cows during normal lactation in the Pondok Ranggon area, East Jakarta were collected to be evaluated for the possibility of coming from quarters suffering from subclinical mastitis. Each milk sample was tested with 3 types of tests, i.e. the Breed method (golden standard) which was based on the number of somatic cells, the device Milkchecker which was based on electrical conductivity, and the Draminski detector which was based on electrical resistance. The results showed that the Draminski detector had a poor level of compatibility with the Breed method as the golden standard (Kappa value 0,013) and the Milkchecker tool (Kappa value 0,036). This test method was also considered to have poor test performance in diagnosing cases of subclinical mastitis in dairy cattle with a sensitivity value of 3,5%, specificity 100%, positive predictive value 100%, negative predictive value 18,8%, estimated prevalence 2,9%, and the true prevalence was 81,7%. In conclusion, the Draminski detector cannot be used to replace the Breed method and Milkchchecker as a screening test tool in cases of subclinical mastitis in dairy farms in Indonesia which were generally reared in the dairy farms.
Effect of Addition of Green Tea Extract (Camellia sinensis) in Egg Yolk Tris Diluter on Spermatozoa Quality in Bali Cattle (Bos sondaicus) After Freezing
Authors: Wijayanti Ani , Suprayogi Tri Wahyu , Prastiya Ragil Angga , Hernawati Tatik , Sardjito Trilas , Saputro Amung Logam , Amaliya Anny , Sulistyowati Deny
Published: April 2023

This study aimed to determine the effect of adding 96% ethanol extract of green tea (Camellia sinensis) in egg yolk tris diluter on the quality of spermatozoa of Bali cattle (Bos sondaicus) after freezing. The samples were divided into four different treatment groups, which contained semen sample + 13% glycerol + each egg yolk tris diluter + green tea extract (P0) 0 mg/100 ml, (P1) 0,05 mg/100 ml, ( P2) 0,10 mg/100 ml, and (P3) 0,15 mg/100 ml. The variables observed included motility, viability, and spermatozoa abnormalities. Data were analyzed using OneWay ANOVA and continued with Duncan's test (p<0,05). The results showed that the P3 group had motility of 49,00 ± 2,15, viability of 61,92 ± 1,70, and abnormality of 4,24 ± 2,16 significantly compared to the other groups. In conclusion, the P3 group with the addition of 0,15 mg/100 ml of green tea could increase the motility, viability, and abnormal spermatozoa of Bali cattle.
The Effectiveness of Ethanol Extract of Gamal Leaves (Gliricidia sepium) on Ascaridia galli Mortality in Vitro
Authors: Sandy Berliana Dwi Nandita , Suprihati Endang , Yudhana Aditya , Hastutiek Poedji , Wibawati Prima Ayu , Praja Ratih Novita
Published: April 2023

This study aimed to determine the anthelmintic activity of the ethanol extract of gamal leaves (Gliricidia sepium) against Ascaridia galli in vitro. There were six treatment groups and each consisted of four replicates. This study used ten A. galli in each treatment for all replications. Observation and recording of death of A. galli was carried out at the 2nd, 4th, 6th, 8th, 10th and 12th hours. Death of A. galli was declared if there was no movement when clamped with anatomical tweezers. The data obtained were analyzed using the ANOVA test and continued with Duncan's test. The results showed that the ethanol extract of gamal leaves had an anthelmintic effect on A. galli worms in vitro. The extract with a concentration of 5% has almost the same anthelmintic properties as piperazine citrate 10 mg/ml. In conclusion, the higher the concentration of the extract, the higher the anthelmintic properties.
The Potential of Kaliandra Honey (Calliandra sp.) on Sertoli Cell Counts in Malnourished Albino Rats
Authors: Erlangga Made Bagus , Srianto Pudji , Safitri Erma , Rimayanti Rimayanti , Hernawati Tatik , Hermadi Herry Agoes
Published: April 2023

This study was performed to investigate the effect of calliandra honey (Calliandra sp.) on the number of sertoli cells in malnourished male albino rats. A total of 24 male rats were divided into four groups, i.e. (K) without treatment, (P0) fasted, (P1 and P2) respectively fasted and administered honey concentrations of 30% and 50% for 10 days after fasting. The results showed that administration calliandra honey with a concentration of 30% and 50% significantly increased the number of sertoli cells. It can be concluded that administration calliandra honey can have a positive effect on malnourished male rats, especially in improving the number of sertoli cells.
PROCESSING REMOVABLE ORTHODONTIC APPLIANCE FOR SINGLE TOOTH ANTERIOR CROSSBITE USING EXPANSION SCREW
Authors: Goenharto Sianiwati , Rusdiana Elly , Nirmala Ratna Harda Sasadhara , Wahjuni Sri , Indiani Sri Redjeki
Published: April 2023

Background: Anterior crossbite is a case that when upper anterior are positioned palatally than lower anterior teeth in centric occlusion. Orthodontic appliances using expansion screw could be solution for tooth anterior crossbite treatment. Purpose: To figure out the optimal fabrication process of orthodontic appliances in single tooth anterior crossbite case using expansion screw. Case analysis: Dental laboratory provided the maxillary dental appliance with single tooth anterior crossbite on teeth 21. Dental technician also received orthodontic appliance using expansion screw. Result: Orthodontic appliance design was Adams claps on teeth 16, 26, labial bow on teeth 13, 12, 11, 21, 22, 23. Additional posterior bite plane, also expansion screw was located on maxillary left first incisor, palatal section. Conclusion: Design and making orthodontic appliances using expansion screw begins with drawing design, positioning Adams clasps and labial bow sectional screw mini mounting, then acrylic packing. Final step was finishing polishing acrylic plate.
THE ANALYSIS OF THE RISK FACTORS OF UNSAFE BEHAVIOR AMONG CONSTRUCTION WORKERS IN TANGERANG
Authors: Andrea Dio Rafly , Handayani Rini , Situngkir Decy , Millah Izzatu
Published: April 2023

Background: The Minister of Manpower stated that the construction sector contributed to the highest number of work accidents. The cause of construction-sector work-accidents as much as 40% came from unsafe behavior from workers. Unsafe behavior is described as the possibility of individuals not following safety standards, procedures, instructions, and criteria specific to the work that the organization applies to. According to a preliminary study, 6 out of 10 workers (60%) have unsafe behavior while working. Purpose: To find out the risk factors of unsafe behavior in construction workers at the Cartenz apartment construction project in Tower D, PT. Nusa Raya Cipta, Tangerang in 2021. Method: A cross-sectional design was used in this present study. The population and sample included 42 workers that were used as total sampling technique. The primary data were collected by questionnaire, whereas the analysis was done with the Chi-square test in bivariate analysis. Result: The analysis showed that 40.5% workers had unsafe behavior, 45.2% had poor knowledge, 31% showed bad attitudes, 52.4% had new work period, and 42.9% had poor supervision. Bivariate analysis indicated that knowledge (p-value 0.016), attitude (p-value 0.028), work period (p-value 0.004), and supervision (p-value 0.041) are associated with unsafe behavior. Conclusion: The risk factors of unsafe behavior in construction workers in Tangerang include knowledge, work period, attitudes, and supervision.
NOISE MAPPING IN THE TURBINE AREA AT PT POMI
Authors: Ismara Nareswari  , Ahmad Imaduddin  , Y. Denny Ardyanto Wahyudiono
Published: April 2023

Background: One of the problems faced by industrial companies that use large machines and work equipment is noise. Steam power plant companies will certainly face noise problems in their work areas. PT. Paiton Operation and Maintenance Indonesia is one of the private power generation companies in East Java which manages three units of PLTU (Steam-Electric Power Plant) which in the process operates using a turbo generator. In addition, this company uses machines and equipment that produce noise that can potentially interfere with the health of the workers. Purpose: To map the noise with Golden Surfer software and to analyze the control efforts that had been carried out. Method: This research used an observational method and the analysis was done using Golden Surfer software. Result: The results of this study indicated that in general the noise that occurred in the turbine area exceeded the threshold value which was >85 dB. Furthermore, the results of the mapping showed the distribution pattern of noise levels that occurred in the turbine area starting from the first floor to the fifth floor. Noise control efforts were also carried out by the company, including noise measurements, scheduled preventive maintenance for machine repairs, safety sign, audiometric checks, work procedures, and PPE. Conclusion: In addition to this noise mapping, noise control efforts that have been carried out by the company will reduce the risk of health problems for workers. Thus, noise mapping can be used as a basic reference for companies to be able to determine additional noise control as an effort to prevent and control noise.
POTENSI BALITA RISIKO STUNTING DAN HUBUNGANNYA DENGAN KELUARGA PRA-SEJAHTERA DI JAWA TIMUR: ANALISIS DATA PK-21
Authors: Nadhiroh Siti Rahayu , Riyanto Edi Dwi , Jannah Sa'idah Zahrotul , Salsabil Ika Savitri
Published: April 2023

Jawa Timur merupakan salah satu provinsi di Indonesia dengan prevalensi stunting pada balita tergolong medium. Pemetaan balita berpotensi resiko stunting diperlukan sebagai informasi awal dalam upaya eliminasi stunting. Penelitian ini bertujuan untuk mempelajari potensi balita risiko stunting di Jawa Timur dan menganalisis hubungannya dengan indicator keluarga pra-sejahtera. Penelitian ini menggunakan data sekunder dari Pendataan Keluarga (PK) 2021. Data diperoleh melalui sensus dengan mendata seluruh keluarga yang menjadi target sasaran di Jawa Timur. Pengumpulan data melalui kunjungan rumah menggunakan formulir F/I/PK/21 dan diinput langsung melalui aplikasi berbasis smartphone.  Pemetaan Keluarga Sasaran Berpotensi Risiko Stunting dalam penelitian ini menggunakan salah satu penapisan yaitu keluarga pra-sejahtera. Data disajikan secara deskriptif dalam bentuk gambar. Analisis data menggunakan uji korelasi Pearson. Terdapat 11.848.066 kepala keluarga di Jawa Timur yang telah terdata. Jumlah balita potensi risiko stunting terbesar terdapat di Kabupaten Malang, Jember, dan Kota Surabaya. Sedangkan berdasarkan presentase, wilayah dengan balita potensi risiko stunting terbesar adalah Kab. Sampang, Bangkalan, dan Sumenep. Dapat disimpulkan bahwa, balita berpotensi risiko stunting dan keluarga pra-sejahtera di Jawa Timur terkonsentrasi pada Kota/Kabupaten tertentu. Hasil analisis statistic menunjukkan potensi risiko stunting berhubungan dengan keluarga dengan ada anak 7-15 tahun tidak sekolah (p-value<0,001), keluarga dengan tidak ada anggota keluarga yang memiliki sumber penghasilan untuk memenuhi kebutuhan pokok per bulan (p-value=0,001), tidak setiap anggota keluarga makan “makanan beragam” paling sedikit 2 kali sehari (p-value<0,001) serta keluarga pra-sejahtera (p-value<0,001). Diperlukan percepatan pengentasan keluarga pra-sejahtera melalui indicator yang ditetapkan serta peningkatan anggaran dan program percepatan penurunan stunting pada Kabupaten/Kota dengan potensi risiko stunting terbesar.
Pembuatan Protipe Sarana Air Bersih Sebagai Solusi Alternatif Percepatan Penurunan Stunting di Kabupaten Pacitan
Authors: Rahmawati Deti , Soedjono Eddy Setiadi , Soedarso Soedarso , Margini Nastasia Festy , Mukodi Mukodi
Published: April 2023

Kasus stunting di Kabupaten Pacitan Tahun 2022 mencapai 22,77% angka tersebut merupakan angka yang cukup tinggi dan melampaui ambang batas yang ditetapkan oleh WHO yakn sebanyak 20%. Hasil penelitian kami di Kabupaten Pacitan faktor utama penyebab kasus stunting adalah adanya kemiskinan yang membuat efek domino pada hal lainnya, Minimnya asupan gizi pada anak serta adanya budaya pernikahan dini dibeberapa daerah. Dalam jangka Panjang, stunting  berpotensi memperlambat perkembangan otak yang kemudian akan berdampak pada keterbelakangan pertumbuhan baik secara fisik maupun mental. Kondisi stunting sangat erat kaitanya dengan kondisi lingkungan yang tidak sehat seeprti tidak tersedianya sarana air bersih dan sanitasi yang layak. Oleh karena itu, dilakukan upaya untuk menyediakan sarana air bersih di 10 desa lokus stunting melalui program Prototipe sarana air bersih. Program ini dilakukan oleh dosen, mahasiswa, dan masyarakat desa secara swadaya. Pembangunan prototipe sarana air bersih ini diharapkan mampu membuka akses masyarakat terhadap air bersih sehingga angka prevalensi stunting di Pacitan dapat diturukan.
Status Ekonomi Keluarga dan Kecukupan Gizi dengan Kejadian Stunting pada Anak Usia 6-24 Bulan di Kota Surabaya
Authors: Ayuningtyas Hasanah , Nadhiroh Siti Rahayu , Milati Zida Sinata , Fadilah Alfin Lailatul
Published: April 2023

ABSTRAK
Stunting merupakan masalah gizi kronis yang sering dialami oleh anak di dunia. Kejadian stunting menandai bahwa anak tersebut tidak cukup gizi. Ketidakcukupan gizi merupakan salah satu faktor penyebab stunting yang juga dapat dipengaruhi oleh status sosial ekonomi keluarga. Tujuan penelitian adalah menganalisis hubungan status ekonomi keluarga dan kecukupan gizi dengan stunting pada anak usia 6-24 bulan di Kota Surabaya. Penelitian ini menggunakan desain cross sectional kepada 160 ibu dan anak usia 6-24 bulan yang dipilih menggunakan consecutive sampling di wilayah kerja Puskesmas Tanah Kalikedinding, Putat Jaya, Bangkingan, dan Sememi. Variabel penelitian adalah asupan gizi anak menggunakan recall, pendapatan keluarga dengan kuesioner, serta status gizi yang dikumpulkan dengan pengukuran tinggi badan menggunakan length board atau microtoise. Analisis statistik yang digunakan adalah uji chi square. Penelitian ini menunjukkan bahwa sebagian besar keluarga memiliki pendapatan dibawah UMK kota Surabaya (78,8%). Kecukupan energi pada anak usia 6-24 bulan (50,6%) dan karbohidrat (57,5%) berada pada kategori defisit, kecukupan protein (75,6%) dan lemak (40%) terbanyak berada pada kategori lebih, dan kecukupan zat gizi mikro Fe kurang (51,3%) serta zink (78,1%) dan kalsium (65,6%) dalam kategori cukup. Hasil uji chi square menunjukkan  hubungan signifikan antara kecukupan zat besi (p value = 0,021) dan kalsium (p value = 0,000) terhadap kejadian stunting anak usia 6-24 bulan. Kesimpulannya adalah status ekonomi keluarga anak tergolong rendah serta terdapat hubungan antara tingkat kecukupan zat besi dan kalsium pada anak 6-24 bulan di Surabaya dengan kejadian stunting.
Kata kunci— stunting, kecukupan gizi, pendapatan keluarga