bluuebunny/crossref_metadata_2025 huggingface dataset:
Socioeconomic Deprivation and the Risk of Sight-Threatening Diabetic Retinopathy: A Population-Based Cohort Study in the U.K.
Authors: Tan Luyuan , Wang Jingya , Han Jieun , Sainsbury Christopher , Denniston Alastair K. , Crowe Francesca L. , Toulis Konstantinos A. , Karamat Muhammad Ali , Yao Mi , Nirantharakumar Krishnarajah
Published: February 2024

OBJECTIVE

To evaluate the associations between socioeconomic deprivation and sight-threatening diabetic retinopathy (STDR) in individuals with type 1 diabetes (T1D) and type 2 diabetes (T2D).

RESEARCH DESIGN AND METHODS

Data from 175,628 individuals with diabetes in the Health Improvement Network were used to assess the risk of STDR across Townsend Deprivation Index quantiles using Cox proportional hazard regression.

RESULTS

Among individuals with T1D, the risk of STDR was three times higher (adjusted hazard ratio [aHR] 2.67, 95% CI 1.05–7.78) in the most deprived quintile compared with the least deprived quintile. In T2D, the most deprived quintile had a 28% higher risk (aHR 1.28; 95% CI 1.15–1.43) than the least deprived quintile.

CONCLUSIONS

Increasing socioeconomic deprivation is associated with a higher risk of developing STDR in people with diabetes. This underscores persistent health disparities linked to poverty, even within a country offering free universal health care. Further research is needed to address health equity concerns in socioeconomically deprived regions.
Experimental Investigation of Void Coalescence in XTral-728 Plate Containing Three-Void Cluster
Authors: Rahman Mohammad Atiqur , Uddin Md Mesbah , Kabir Latiful
Published: February 2024

Void clustering effect is investigated by performing uniaxial tensile test on commercial 95% aluminum alloy XTral 728 by strategically placing an additional hole. Incorporating additional void induces strong stress and strain localization and reduces incipient coalescence strain approximately 17%. Also, two different cluster orientations with respect to applied loading and hole spacing ratios have been considered. The experimental revealed that material ductility is significantly decreased with increasing hole spacing ratios and for certain cluster orientation. To evaluate existing void coalescence models, numerical simulations are also performed and found that existing models overestimate the incipient coalescence strains for considered three-void cluster.
Understanding Persistent ZLB: Theory and Assessment
Authors:   Board of Governors of the Federal Reserve System, Cuba-Borda Pablo A. , Singh Sanjay R. ,   Federal Reserve Bank of San Francisco
Published: February 2024

We develop a theoretical framework that rationalizes two hypotheses of long-lasting low interest rate episodes: deflationary-expectations-traps and secular stagnation in a unified setting. These hypotheses differ in the sign of the theoretical correlation between inflation and output growth that they imply. Using the data from Japan over 1998:Q1-2019:Q4, we find that the data favor the expectations-trap hypothesis. The superior model fit of the expectations trap relies on its ability to generate the observed negative correlation between inflation and output growth.
Fluid-mineral Equilibrium Under Nonhydrostatic Stress: Insight From Molecular Dynamics
Authors: Mazzucchelli Mattia L. , Moulas Evangelos , Kaus Boris J. P. , Speck Thomas
Published: February 2024

The interpretation of phase equilibria and reactions in geological materials is based on standard thermodynamics that assumes hydrostatic and homogeneous stress conditions. However, rocks and minerals in the lithosphere can support stress gradients and nonhydrostatic stresses. Currently, there is still not an accepted macroscopic thermodynamic theory to include the effect of nonhydrostatic stress on mineral reactions, and the use of several thermodynamic potentials in stressed geological system remains under debate. In experiments under nonhydrostatic stress, it is often difficult to resolve the direct effect of differential stress on phase equilibria because pressure gradients may be developed. Such gradients can affect the metamorphic equilibria at the local scale. Here, we investigate the direct effect of a homogeneous, nonhydrostatic stress field on the solid-fluid equilibrium using molecular dynamics simulations at non-zero pressure and elevated temperature conditions. Our results show that, for simple single-component systems at constant temperature, the equilibrium fluid pressure of a stressed system is always larger than the value of fluid pressure at hydrostatic stress conditions. The displacement of the equilibrium value of the fluid pressure is about an order of magnitude smaller compared to the level of differential stress in the solid crystal. Thus, phase equilibria can be accurately predicted by taking the fluid pressure as a proxy of the equilibration pressure. On the contrary, the mean stress of the solid can deviate substantially from the pressure of the fluid in stressed systems at thermodynamic equilibrium. This has implications on the use of thermodynamic pressure in geodynamic models since the fluid pressure is a more accurate proxy for predicting the location of metamorphic reactions, while the equilibrium density of the solid has to be determined from its mean stress.
Geomarketing as an important element of a food retailer’s business model: A managerial view
Authors: Kita Pavol , Maciejewski Grzegorz , Žambochová Marta , Križan František
Published: February 2024

The aim of the study is to explore how geomarketing becomes a key element in managing the business model (BM) of an established retailer on the food market. The survey sample comprised 244 stores, whose managers were questioned by means of a semi-structured interview in 2021. Cluster analysis was used to assess 40 statements from the managers about the BMs of the current store. The resulting clusters indicate, among others, that large retailers devote more and more attention to the analysis of a territory, and their decision-making deepens even more due to the use of a multi-format strategy on the food market. The article contributes to the discussion about the market within geomarketing research in terms of both theory and practice at a time when the population’s income is expected to decrease due to several crises, for example, health-economic and energy, on the food market.
Drones’ contribution to the transformation of contemporary warfare
Authors: Koukoudakis George
Published: February 2024

The introduction of unmanned aerial vehicles (UAVs) in contemporary battlefields constitutes a transformation in warfighting. The consequences of such an innovation can be traced not only to the level of strategy but also in political, economic as well as ethical terms. So far, UAVs have demonstrated decisiveness in non-military contested environments and in conflicts that involve failed states. UAVs, however, have been proved to be militarily effective, but not militarily decisive in conventional wars. Simultaneously, a series of limitations makes over-reliance on them to look faulty. Time will tell whether their further technological advancements will be able to revolutionise the conduct of war.
Parental Involvement and Academic Achievement: Keys to Translating No Poverty and Quality Education SDGs in Philippine Peripheral Communities
Authors: Maimad Marisol T. , Dupa Helina Jean P. , Villegas Jhonnel P.
Published: February 2024

The Pantawid Pamilyang Pilipino Program (4Ps) is a conditional cash transfer (CCT) program to alleviate socio-economic conditions in the Philippines, addressing Sustainable Development Goals (SDGs) 1 (No Poverty) and 4 (Quality Education). It attempts to address poverty, which is a risk factor to education among Filipinos. However, the program impact on education and economy remains understudied. This paper investigated the recipients of the CCT and analyzed parental involvement and its influence on students’ academic achievement. In this study, parental involvement refers to parenting, learning at home, volunteering, school decision-making, collaborating, and communicating, while academic achievement pertains to the students’ academic performance in the core learning areas: Science, Mathematics, English, and Filipino. Using a descriptive-correlation method, the respondents were randomly selected comprising 306 parents and 306 students in Tarragona District, Davao Oriental, Philippines. The data were analyzed using Spearman Rho Correlation and Confirmatory Factor Analysis (CFA). The results showed there was no statistical correlation between parental involvement and student’s academic achievement. Parents had low involvement in learning at home, volunteering, and school decision-making. On the other hand, the students demonstrated high academic achievement in the core learning areas. The significant step of the Philippine government for education through the CCT is an effective approach to keeping children in school. Emphasis must be placed on strengthening parental involvement in children’s education to ensure academic success.
Aktuelle Diskussionen zum Ausbau kapitalgedeckter Altersvorsorge als Ergänzung des Rentensystems
Authors: Haupt Marlene
Published: February 2024

Germany faces complex challenges in ensuring adequate pensions and the financial sustainability of its pension system amid demographic aging, necessitating comprehensive reforms. The Focus Group on Private Pensions has proposed measures to reform the private Riester pension scheme, advocating, for example, the enhancement of simplicity, transparency and flexibility. Additionally, it has debated the introduction of a state-mandated fund. The German Council of Economic Experts has also proposed a state-mandated fund with automatic enrollment and an opt-out option. However, the proposal faces skepticism and is widely debated. Despite this, the discussion on a state-mandated fund remains relevant, with political party initiatives even considering mandatory funded pensions.
Eine effektive Grundrente ermöglicht notwendige Rentenreformen
Authors: Haan Peter
Published: February 2024

In the coming years, the pension system in Germany will face financial challenges. The insurance within pension system must also be strengthened, especially given that the risk of old-age poverty has increased over the years. An effective basic pension that guarantees a minimum amount and is anchored in the pension system would be an important step in reducing poverty in old age. An effective basic pension is also an important prerequisite for implementing necessary pension reforms in Germany, such as increasing the retirement age or stronger (funded) private provision.
Reformoptionen – die keine sind
Authors: Ruland Franz
Published: February 2024

In the German pension debate, reform options are repeatedly proposed that are doomed to failure right from the start as they cannot be legally implemented to begin with. One of these is the inclusion of civil servants in the German state pension scheme. This option, however, is prohibited by the German Constitution. Another example is the inclusion of self-employed persons. This demand cannot be met as many freelancers are unable to pay their full contributions. Inflation adjustment of pensions would mean too much of a burden for women as well as for the sick and the disabled. Redistributing money from pensioners with high benefits to pensioners with a low pension would not be conducive, either. Not only would this mean an infringement of the principle of equality, but also there are too few high pensions to redistribute.
Die Legalisierung von Cannabis in Deutschland
Authors: Beck Hanno , Prinz Aloys
Published: February 2024

The federal government has presented a draft law to legalise the controlled use of cannabis, known as the Cannabis Act (CanG). What does this law regulate and how is it expected to affect cannabis use? Is there empirical evidence to support the expectations? What will determine whether the objectives of the law can be achieved or not? This article describes the main provisions of the Cannabis Act and the criticism of it and also examines the possible consequences of this law with a view to the empirical literature.
Fortschritte bei Frauen in Führungspositionen – doch weitere Anstrengungen nötig
Authors: Sondergeld Virginia
Published: February 2024

Women’s representation on corporate boards of German companies increased again in 2023. In the largest 200 firms, 18 % of executive board members and 32 % of supervisory board members were women. However, in most companies, there is at most one woman on the executive board and the share of women among CEOs has decreased in many places. Companies, policymakers and other stakeholders must make greater efforts to achieve parity. An analysis of IAB data shows that a higher share of women as managers in establishments decreases the gender pay gap among subordinates, however, only if the share at the highest management level exceeds one-third.
Buccal corridor and gummy smile treatment with MARPE and gingivoplasty: A 2-year follow-up case report
Authors: Hoang Viet , Tran Phuoc Hong , Dang Thao Thi Nhu
Published: February 2024

The advent of Mini-screws assisted rapid palatal expansion (MARPE) has introduced a simpler in-office procedure that enables the translation of the alveolar process in adults. This case report showed the combination of MARPE, orthodontic treatment, and gingivoplasty to correct malocclusion and enhance smile aesthetics. A 20-year-old woman expressed concerns about excessive buccal corridors and a gummy smile. She exhibited skeletal class I malocclusion, with buccal corridors exceeding 4 mm, a gummy smile, and lingual tipping of the lower posterior segments. The treatment plan involved utilizing the MARPE appliance, a Nitinol wire, gingivoplasty to address the gummy smile. Retention evaluations demonstrated the stability of MARPE in transversal skeletal discrepancies. There was notable improvement in incisor inclination and soft tissue profile, particularly evident in the E-line and nasolabial angle. Cephalometric analysis confirmed these changes, showing a decrease of 5.9 degrees in the inclination of the maxillary incisors. After a 2-year follow-up, the results remain stable, and the patient expresses satisfaction with the outcome. MARPE can be considered as an effective tool for managing buccal corridors, complemented by fixed orthodontic treatment employing labial appliances and gingivoplasty to correct malocclusion and enhance smile aesthetics. The treatment showed positive long-term outcomes.
Kajian Paham Utilitas dan Manfaat Pendidikan Seni Bagi Anak Usia Dini
Authors: Grandena Egi Putri
Published: February 2024

To appreciate art and education as a whole requires access to discussions from various dissections of study with certain theories. In this paper, the author examines utility theory in relation to the benefits of arts education as a whole. As utility is an understanding with the principle of priority, namely efforts to fully maximize welfare or principles that prioritize the achievement of a sense of human happiness. In this paper, the author examines the principle of utility and the benefits of art education for early childhood so that they can explore the importance of art education as a whole for growth and development in early childhood. Children at an early age range between the ages of 0-6 years and this is the golden age. During the golden age, all child development can jump very drastically. At this age stage it is important to instill basic education which will become the basic foundations that are important for the growth and development of children. Thus, early childhood get provision of basic values that are instilled from an early age, as a preparation to go to the next level of education, namely the elementary school level.
SENI & BUDAYA TARI MANIAMAS DAYAK BIDAYUH DENGAN BIBLIOGRAFI SEBAGAI UPAYA PELESTARIAN
Authors: Azizan Muhammad , Hanum Atiqa Nur Latifa
Published: February 2024

Penelitian ini bertujuan untuk meneliti tentang Dokumentasi Seni & Budaya Tari Maniamas Dayak Bidayu, sebagai tari sacral dan diwariskan secara turun – temurun antara generasi – ke generasi. Dalam pembuatan Blibliografi terkait seni & budaya tari maniamas, proses nya diawali dengan 1). Menentukan ruang lingkup subjek, 2). Pengumpulan Data 3). Pengklasifikasian, 4). Koreksi Data, 5). Tata Letak Naskah, 6). Penyuntingan Naskah 7). Pencetakan Naskah MasterKata kunci: Dayak Bidayuh, Tari Maniamas, Seni, Budaya.
ANALISIS PERMAINAN TAMMBONG PADA TARI JEPIN TAMMBONG ANNAM DI DESA KARIMUNTING KECAMATAN SUNGAI RAYA KEPULAUAN KABUPATEN BENGKAYANG
Authors: Aditya Yoga
Published: February 2024

Permasalahan penelitian ini berkaitan dengan Analisis Permainan Tammbong pada tari Jepin Tammbong Annam. Penelitian ini bertujuan untuk mendeskripsikan Permainan Tammbong pada Tari Jepin Tammbong Enam. Menggunakan metode deskripsi dengan bentuk kualitatif dan pendekatan etnokoreologi. Sumber data penelitian berupa hasil observasi, wawancara, dan dokumentasi dengan narasumber Suratmi, Mat’ani dan Ruslan. Perpanjangan pengamatan dan triangulasi sumber digunakan sebagai teknik menguji keabsahan data dengan teknik analisis data reduksi, penyajian serta verifikasi data. Hasil penelitian ini terdapat tiga pola pukul dengan desain lantai berupa garis vertikal, horizontal dan segitiga dengan desain atas datar, lurus, bersudut, simetris, rendah, vertikal dan dalam. Dinamika tidak bervariasi dan tidak memiliki desain dramatik dengan kompisisi kelompok menggunakan desain serempak dan berimbang. Alat musik beruas, gambus, rumba dan syair dengan tata rias natural dan tata busana baju telok belanga, celana, kain dan ikat kepala. Tempat pertunjukan berupa proscenium, arena, panggung tertutup, dan lapangan serta menggunakan properti tammbong. Kata kunci : Jepin Tammbong Annam, Kualitatif, Dinamika, Tempat Pertunjukan.
MAKNA, RAGAM DAN EKSPRESI TARI WANKA
Authors: Purwaningsari Dewi
Published: February 2024

Artikel penulisan ini bermaksudkan untuk menanalisi bagaimanakah  makna, ragam, dan ekspresi yang terdapat dalam Tari Wanka. Tari Wanka merupakan ke dalam jenis karya tari kreasi baru dengan berpijakan non tradisi. Tari Wanka sendiri merupakan karya tari yang berkisahkan tentang kehidupan kuli tiongkok yang berada di Bangka dan bekerja sebagai penambang timah. Metode penelitian ini yaitu dengan metode penelitian kualitatif, yaitu data observasi dengan cara mengobservasi karya tari ini. Data wawancara dilakukan dengan cara wawancara virtual, yaitu wawancara melalui media telepon whatsapp, zoom muapun dengan Google Meet. Sedangkan data dokumentasi diperoleh dengan data yang telah ditemukan sebelumnya. Hasil temuannya yaitu berupa ada beberapa ragam gerak yang terdapat dalam Tari Wankadan juga ekspresi yang digunakan dengan ekspresi dingin, datar, permebrontakan/melawan, dan juga penuh kelesuan.
Melt Spinning of Polypropylene Fiber
Authors:   Department of Textile Engineering, Kombolcha Institute of Technology, Wollo University, Ethiopia, Wolela Asaye Dessie
Published: February 2024

In this paper the melt spinning process and technology of polypropylene fiber, polymerization conditions, preparation of polypropylene fiber by a larger variety of processes and the stress in the spinline was presented. More emphasis was given on the various polymerization processes (gas-phase and liquid-phase polymerization), catalyst system, different forms of polypropylene, structure, properties and application of polypropylene. Polypropylene fibers are produced by a larger variety of processes than other melt-spun fabrics. Polypropylene based materials can be processed by various technologies such as injection molding, calendaring, air-quenched blow films, spinning technology, spunbond process. The influence of both process and material variables on the spinnability and the development of the structure during melt spinning of filament were also discussed.
The Role of Textile Materials in Sports Footwear: A Comprehensive Review
Authors:   Department of Fashion Technology, National Institute of Fashion Technology, Kannur, Kerala-670 562, India, Roy Rupayan , Udhayakumar Gayathri ,   Department of Fashion Technology, National Institute of Fashion Technology, Kannur, Kerala-670 562, India, Bhardwaj Parinita ,   Department of Fashion Technology, National Institute of Fashion Technology, Kannur, Kerala-670 562, India
Published: February 2024

This article explores the application of textile materials in sports shoes, examining their types, properties, advantages, challenges, and innovations. Textile materials have revolutionized the sports shoe industry, providing improved performance, increased comfort, enhanced style, and eco-friendly options. Different types of textile materials such as natural, synthetic, and blended, are used in different parts of sports shoes such as upper, insole, midsole, and outsole. Innovative technologies such as 3D printing, knitting, weaving, and nanotechnology offer exciting opportunities for creating even more innovative and high-performance sports shoes. However, challenges such as wear and tear, cleaning and maintenance, and pricing must be addressed by manufacturers. Overall, the use of textile materials in sports shoes has transformed the industry, and as technology and sustainability continue to advance, we can expect even more exciting developments in the field of textile materials for sports shoes.
Modification of Jute Fiber with Vinyl Acetate and Methyl Vinyl Ketone for Textile Applications
Authors:   Polymer and Textile Research Lab, Department of Applied Chemistry and Chemical Engineering, Rajshahi University, Rajshahi-6205, Bangladesh, Rahman Md. Hasinur , Alam Md. Jahangir ,   Polymer and Textile Research Lab, Department of Applied Chemistry and Chemical Engineering, Rajshahi University, Rajshahi-6205, Bangladesh, Mondal Md. Ibrahim H ,   Polymer and Textile Research Lab, Department of Applied Chemistry and Chemical Engineering, Rajshahi University, Rajshahi-6205, Bangladesh
Published: February 2024

In the present study, the bleached jute fiber was been modified with Vinyl Acetate (VA) and Methyl Vinyl Ketone (MVK) by graft co-polymerization in an aqueous medium using potassium persulphate as an initiator, under the catalytic influence of FeSO4 in the presence air to improve physicochemical properties. The maximum graft yield and grafting efficiency at the optimized condition for VA and MVK are 26.0%, 11.1% and 10.4%, 3.7% respectively. The graft yield and grafting efficiency of VA-modified fiber were higher than that of MVK-modified field fiber. The grafted fiber was characterized by FTIR, SEM and TGA. FTIR spectra of VA and MVK modified fiber have peaks at 1741cm-1 and 1714cm-1 respectively than the unmodified jute indicating the incorporation of vinyl monomer with the cellulosic jute fiber. By observing thermograms, the degradation temperature of bleached jute fiber was 318.7�C and that for VA and MVK modified fibers was 320�C and 325�C respectively. The breaking strength of bleached fiber was 16.02kg/yarn but VA and MVK modified fibers were 17.3 and 17.00kg/yarn respectively. The dye absorption by modified fiber was slightly decreased than bleached fiber due to the increased hydrophobicity. The wash fastness with soap solution decreased with the increase in washing temperature. The color fastness test of dyed bleached and modified jute fibers spotting with alkalis, and acids were satisfactory with some exceptions. Thus, the modification improves the physicochemical properties of the jute fiber for textile applications.
Single Atom Editing of the Glycosylated Natural Product Fidaxomicin Improves Acid Stability and Retains Antibiotic Activity
Authors: Ferrara Isabella , Chesnokov Gleb A. , Dittmann Silvia , Blacque Olivier , Sievers Susanne , Gademann Karl
Published: February 2024

Fidaxomicin (Fdx) constitutes a glycosylated natural product with excellent antibacterial activity against various Gram-positive bacteria but is only approved for Clostridioides difficile infections. Poor water solubility and acid lability preclude its use for other infections. Herein, we describe our strategy to overcome the acid lability by introducing acid stable S-linked glycosides. We describe the direct, diastereoselective modification of unprotected Fdx without the need to avoid air or moisture. Using our newly established approach, Fdx was converted to the single atom exchanged analogue S-Fdx, in which the acid labile O-glycosidic bond to the noviose sugar is replaced by the acid stable S-glycosidic bond. Studies of the antibacterial activity of a structurally diverse set of thioglycoside derivatives revealed high potency of acyl derivatives of S-Fdx against Clostridioides difficile (MIC range: 0.12–4 μg/mL) and excellent potency against Clostridium perfringens (MIC range: 0.06–0.5 μg/mL).
“Hey, You There!”: Theorizing the Open Letter as Methodology in Academic Writing
Authors: Nicholas Rickards
Published: February 2024

From James Baldwin's (1962) “A Letter to My Nephew,” which laid bare the brutalities of being black in 1960s America, to Chanelle Miller’s published victim impact statement addressed to her assailant, which provided vocabulary and was kindle for #MeToo, examples abound demonstrating the ways in which the open letter continuously surfaces during pivotal historical junctures. Although the contextual significance of this format of authorship is widely used in scholarly disciplines ranging from education to history, the structural significance of the open letter as a methodologic approach to academic writing has yet to be theorized, leaving questions that merit attention: Why is the open letter so often used by marginalized groups? What are the literary and rhetorical effects of the enclosed addressed between sender and receiver? Finally, how does this format of writing create and affect the positionality and subjectivity of authors? By writing a letter addressed to Academia/School, this essay makes the case for the open letter as something to be studied but also a methodology and study in and of itself. By drawing on literary theory, cultural studies, and research on writing in academia, this essay suggests that the open letter is an important form of authorship and argues for revisiting the open letter as a legitimate form of scholarship as well as an authentic form of academic writing in education.
Modeling Wind Turbines to Assess Impact of Offshore Wind Farms on Maritime X- and S-band Radars
Authors: Bronk Krzysztof , Koncicki Patryk , Lipka Adam , Niski Rafał , Wereszko Błażej
Published: February 2024

This article discusses several aspects related to modeling the impact of offshore wind farms on maritime radar systems operating in the X and S bands. The first part of the paper focuses on theoretical models and analyses, taking into account radio shadowing and false radar echoes. Additionally, the issue of spatial modeling of wind turbines, with diffraction phenomena considered, is reviewed with the help of suitable propagation models. By relaying on a software-based implementation of the proposed model, the authors carried out a detailed simulation of the impact of wind turbines on radar systems operating in the X and S bands. The results of these simulations are presented and discussed in the second part of the article.
Prognostic Value of Semi-Quantitative 18F-FDG PET/CT Parameters in Hodgkin’s Lymphoma
Authors: Zhou Yong , Hu Congyang , Li Yue , Xia Xiting , Lei Jun , Chen Jingyi , Xu Hua , He Mei , Jian Hongyun , You Shuping
Published: February 2024

Objective: To assess the prognostic value of maximum standardized uptake value (SUVmax), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) determined by 18F-fluorodeoxyglucose positron emission tomography-computed tomography (18F-FDG PET/CT) imaging in Hodgkin’s lymphoma patients. Methods: A total of 148 Hodgkin’s lymphoma patients diagnosed with lymph node biopsy from October 2014 to October 2015 were retrospectively analyzed followed by categorizing into good (125 cases) and poor (23 cases) prognosis groups. The chi-squared test was used to analyze the clinicopathological characteristics of Hodgkin’s lymphoma patients with the semi-quantitative 18F-FDG PET/CT parameters; the Spearman method was used to analyze the correlation between the semi-quantitative parameters and clinicopathological features of Hodgkin’s lymphoma; receiver operating characteristic curve was used to analyze the predictive value of the semi-quantitative parameters for poor prognosis of Hodgkin’s lymphoma patients. Results: Mean SUVmax, MTV, and TLG of the 148 cases of Hodgkin’s lymphoma were 7.26 ± 2.38, 12.46 ± 3.14 cm3, and 76.83 ± 18.56 g, respectively. Significant variations in the Ann Arbor stage and clinical classification were observed with different levels of semi-quantitative parameters (P < 0.05). The semi-quantitative parameters were not correlated with age and gender (P > 0.05) but positively correlated with Ann Arbor stage and clinical classification (P < 0.05). These parameters in the poor prognosis group were higher than those in the good prognosis group (P < 0.05). The area under the curve (AUC) of SUVmax, MTV, and TLG in predicting the poor prognosis group was 0.881, 0.875, and 0.838, with cut-off values of 7.264, 12.898 cm3, and 74.580g, as well as specificity of 88.8%, 84.0%, and 78.4%, and sensitivity of 87.0%, 87.0%, and 78.3%, respectively; the AUC of the combined prediction was 0.986, with a specificity of 97.6% and sensitivity of 86.3%. Conclusion: The semi-quantitative 18F-FDG PET/CT parameters provide valuable insights for Hodgkin’s lymphoma prognosis assessment.
In Vivo Studies and Flow Cytometric Investigation on Anticancer Potential of Selenium Nanoparticles Synthesized via Aqueous Extract of Clerodendron phlomidis
Authors: Subha Veeramani , Shanmugam Kirubanandan , Sahadevan Renganathan
Published: February 2024

Nowadays, doctors and nutritionists recommend individuals incorporate selenium-rich foods such as nuts, cereals, and mushrooms into their regular diet to maintain fitness and overall health. Selenium nanoparticles (SeNPs) exhibit strong chemopreventive capabilities. The anticipations for SeNPs with enhanced and tunable bioactive activities have led to a keen interest in phytofabrication. In this study, the aqueous extract of Clerodendron phlomidis plant leaves was utilized for the synthesis of SeNPs. In traditional Indian medicine, this plant extract is recognized as a significant anti-diabetic agent. The flavonoids tetrahydroxylflavone, 7-hydroxyflavanone, and 6,4’-dimethyl-7-acetoxy-scutellarein present in this plant leaf extract demonstrate excellent anticancer activity. These secondary metabolites exhibit the ability to reduce sodium selenite into SeNPs. At a concentration of 13 µg/mL, the synthesized SeNPs effectively inhibited the proliferation of the HepG2 cell line. The results suggest that the SeNPs possess promising anti-cancer potential against liver cancer and can be considered as a therapeutic agent for liver cancer treatment. Additionally, the cell cycle arrest induced by SeNPs was further confirmed by the fluorescence-activated cell sorting (FACS) method, indicating that SeNPs could efficiently differentiate cancer cells from normal cells. Notably, it showed a significant improvement in diethylnitrosamine (DEN)-induced Swiss Wistar rat groups. This scientific investigation highlights the high anti-cancer potential of SeNPs, positioning them as a promising therapeutic agent for liver cancer treatment.
Analysis of the Role of Cognitive Behavioral Therapy on Self-Care in Thyroid Cancer Patients
Authors: Chai Linlin , Cheng Yakun
Published: February 2024

Objective: To explore the effect of cognitive behavioral therapy on self-care in thyroid cancer patients. Methods: A total of 144 thyroid cancer patients treated at the Affiliated Hospital of Hebei University from January 2022 to August 2023 were selected as research subjects. Using the random number table method, they were divided into a control group and an experimental group, each consisting of 72 cases. The control group received routine nursing intervention, while the experimental group received cognitive behavioral therapy based on standard nursing practices. The self-care ability (self-concept, self-efficacy, self-care skills, health knowledge level), coping style (confrontation, avoidance, and surrender), and quality of life (psychological function, social function, material life, physical function) of both groups before and after the intervention were compared. Results: In comparison to the pre-intervention period, the experimental group exhibited significantly higher self-care ability, quality of life, and confrontation scores after the intervention, as opposed to the control group. Additionally, the avoidance and surrender scores were lower in the experimental group than in the control group, with these differences proving to be statistically significant (P < 0.01). Conclusion: The application of cognitive behavioral therapy can enhance the self-care ability of thyroid cancer patients, aid in better disease coping, and improve their overall quality of life. This approach is deserving of further promotion.
Analysis of the Efficacy, Progression-Free Survival, and Safety of Anlotinib in Advanced Lung Cancer Treatment
Authors: Shen Jie , Meng Cheng , Zhang Xiaoyan , Lei Rong , Hao Liyun
Published: February 2024

Objective: To analyze the clinical efficacy, progression-free survival, and safety of anlotinib in the treatment of advanced lung cancer. Methods: A retrospective analysis was conducted using data from 60 patients with advanced lung cancer treated with anlotinib from May 2019 to May 2021. This analysis aimed to comprehensively evaluate the clinical efficacy, progression-free survival, and adverse reactions of anlotinib. Results: The median progression-free survival (PFS) for the 60 patients was 5.79 months, with an overall response rate (ORR) of 21% and a disease control rate (DCR) of 90%. In the first-line group, the median PFS was 6.20 months, ORR was 76.92%, and DCR was 84.61%. The second-line group showed a median PFS of 6.30 months, ORR of 28.57%, and DCR of 90.48%. In the third-line group, the median PFS was 5.34 months, ORR was 19.23%, and DCR was 92.30%. The single-agent group exhibited a median PFS of 5.09 months, ORR of 23.33%, and DCR of 76.67%. In the combination group, the median PFS was 6.53 months, ORR was 46.67%, and DCR was 100%. The combination group demonstrated a significantly higher medication effect than the single-drug group, and adverse drug reactions were mostly grade 1–2. Conclusion: Anlotinib exhibits a better disease control rate and survival benefit in the treatment of advanced lung cancer. The combination effect is superior to monotherapy, with relatively controllable adverse effects.
Anti-Cancer Agents Associated Diarrhea: Current Status and Prospects
Authors: Wang Hao , Jiang Zhansheng , Tong Zhongsheng
Published: February 2024

Cancer stands as one of the major threats to human life. Ensuring the safety of drugs is paramount, and the impact of adverse reactions on patients’ quality of life and prognosis should not be underestimated. Diarrhea is a common clinical adverse event, and despite the absence of specific anti-diarrhea drugs, there is a pressing need for improvement. This article aims to provide a valuable reference for researchers in clinical drug use and scientific tumor treatment. It summarizes recent advancements in drug mechanisms and adverse reactions, whether in preclinical research or clinical diagnosis and therapy.
Symptom Experience and Quality of Life in Colorectal Cancer Patients Undergoing Chemotherapy – A Secondary Publication
Authors: Lee Ayoung , Park Jin-Hee
Published: February 2024

Objective: To evaluate symptom experience and quality of life (QoL) and to identify the predictors of QoL among colorectal cancer patients undergoing chemotherapy. Methods: A cross-sectional study was conducted on 107 colorectal cancer patients at a university-affiliated hospital between June 1 and July 30, 2021. Functional Assessment of Cancer Therapy-Colorectal (FACT-C) and Memorial Symptom Assessment Scale-Short Form (MSAS-SF) were used to assess symptom experience and QoL of these patients. Data were analyzed using Pearson’s correlation, t-test, ANOVA, and hierarchical multiple regression. Results: The mean QoL score for colorectal cancer patients was 88.78 ± 20.08. The most frequently experienced physical and psychological symptoms were numbness/tingling and worrying. Physical and psychological symptoms have a significant negative association with QoL. Perceived economic status was significantly associated with QoL in patients’ general characteristics. The regression analyses showed that high psychological symptoms (β = -0.63, P < 0.001), middle perceived economic status (β = -0.22, P = 0.009), and low perceived economic status (β = -0.36, P < 0.001) were statistically significant in predicting patients’ low QoL. Conclusion: Symptom experience and QoL are essential variables that should be acknowledged when delivering health care to colorectal cancer patients. More attention to the reduction and comprehensive symptom management of psychological distress could improve QoL among colorectal cancer patients.
Exploration of PAI Teacher Challenges and Opportunities; Case Study of Implementation The Independent Learning Curriculum, In East Lombok Elementary Schools
Authors: Rasyidi Abdul Haris , Idrus S. Abdul Jalil Al
Published: February 2024

Education in Indonesia is experiencing a significant transformation, one of the concrete steps in dealing with this development is the implementation of the Independent Learning Curriculum. The Independent Learning Curriculum carries the principle of inclusivity and views every child as an individual who has unique potential, however it still has several challenges and opportunities for Islamic religious education teachers. This study focuses on the challenges of Islamic religious education teachers in implementing, knowing opportunities for teachers and analysing the role of the independent learning curriculum in learning Islamic religious education in elementary schools. The method in this research is a case study using a qualitative design with a phenomenological approach. Data collection techniques use semi-structured interviews, observation and documentation techniques. Data sources are PAI teachers, school principals and PAI Teacher Working Groups in 32 elementary schools in East Lombok. Thematic analysis is used to analysis the extent to which curriculum implementation can be implemented. The results of the research identified several challenges faced by PAI teachers, including adapting student-focused learning approaches, limited resources and infrastructure and strengthening curriculum evaluation. Other findings include opportunities for PAI teachers to utilize technology, increase student engagement, collaboration between subjects for cross-disciplinary learning and an emphasis on developing student skills. In conclusion, PAI teachers need to strive to align PAI learning with curriculum vision and principles that include student-based, contextual and collaborative learning. Meanwhile, opportunities that can be exploited include making PAI learning more interesting, relevant and collaborative and PAI teachers being able to utilize the role of the independent learning curriculum as an opportunity to improve the quality of Islamic religious education in elementary schools, helping students understand religious values and teachings, and being able to support character education efforts based on moral values.
Human Resource Productivity: Integrating Resilience Engineering, Motivation, and Health Safety
Authors: Putra Ida Bagus Udayana , Kot Sebastian , Ibrahim Abdul Halil Hi , Rajiani Ismi
Published: February 2024

This study investigated the multifaceted relationship between resilience engineering practices, work motivation factors, health, safety, and environment (HSE) management to achieve employee productivity within a mining company in South Kalimantan, Indonesia. Employing structural equation modelling (SEM) on data from 178 workers, intriguing results are diverged from established research. While resilience engineering practices and work motivation factors significantly enhanced productivity, robust HSE management demonstrated a surprisingly insignificant association. This unexpected finding necessitates a closer examination of the unique context of Indonesian mining culture and HSE implementation practices. Several potential explanations emerge, including ingrained communal responsibility for safety, limited applicability of imported frameworks, prioritisation of immediate needs over long-term safety due to competitive pressures, and possible erosion of trust in bureaucratic systems. These factors highlight the need to consider cultural nuances and industry challenges when designing effective HSE interventions. Moving forward, research and practice must prioritise developing culturally sensitive HSE practices, fostering trust and employee engagement, bridging the gap between formal systems and daily realities, and gathering qualitative data to understand employee perspectives. By addressing these considerations, future interventions can effectively align HSE efforts with employee productivity, contributing to a safer, more productive, culturally relevant work environment for Indonesian miners.
atención a la diversidad para la educación emocional desde la función orientadora del docente.
Authors: Delgado González Yaima , Chinea Gómez Laritza , Ruíz Pérez Odalis
Published: February 2024

El desarrollo de la orientación en las instituciones educativas es una prioridad para la labor del docente en su propósito de vincular la instrucción con la educación erigiéndose como un reto de la escuela actual que los docentes se entrenen en el desempeño exitoso de esta función, para descubrir o ratificar la necesidad de ayudar a sus educandos tomando como punto de partida la atención a las diferencias individuales. El artículo se enmarca en el tratamiento a la orientación desde el contexto escolar en lo individual y grupal, considerando las necesidades y potencialidades de los educandos que permita su formación integral. La investigación ofrece núcleos esenciales en el logro de tal aspiración y direcciona la atención de los docentes a las bases de la orientación educativa, en relación con los aprendizajes para la vida los que constituyen esenciales en la educación emocional. En el estudio realizado se emplean métodos del nivel teórico los que posibilitan la profundización y sistematización de prácticas educativas en otros contextos, el propósito de esta investigación es reflexionar desde el punto de vista teórico y metodológico sobre la atención a la diversidad para la educación emocional desde la función orientadora del docente.
Análisis de un indicador de calidad de la etapa preanalítica en el servicio de microbiología clínica Hospital Perrando, Chaco Argentina
Authors: Carol Rey Mariana Carina , Tracogna María Fernanda , Gariboglio Vázquez María Lucrecia
Published: February 2024

Los errores de la etapa preanalítica pueden alcanzar valores del 70 %, afectando etapas subsiguientes con riesgo en la seguridad del paciente. Es imprescindible garantizar la identificación correcta de los pacientes. Las herramientas informáticas ayudan en este proceso, pudiendo ser objeto de ataques cibernéticos. El objetivo del trabajo fue evaluar el nivel de desempeño de un indicador de calidad de la etapa preanalítica, observándose una disminución del valor del mismo, en los meses en los que el sistema de control de ingreso de pacientes del Hospital Dr Julio C Perrando (HJCP) de la ciudad de Resistencia, Chaco, sufrió un ataque cibernético.
Oyun Deneyimi Ölçeği’nin Türkçe Geçerlik ve Güvenirliği: Metodolojik Bir Çalışma
Authors: Arıkan Dönmez Ayşe , Çalık Afra , Kabal Murat Gökhan , Kapucu Sevgisun
Published: February 2024

Amaç: Metodolojik desende yürütülen bu araştırmada, oyun deneyimini belirlemeye yönelik geliştirilen “Oyun Deneyimi Ölçeği (Gameful Experience Scale-GAMEX)” ölçüm aracının Türkçe geçerlik ve güvenirlik çalışmasının yapılması amaçlandı.
Gereç ve Yöntem: Araştırmanın örneklemini bir devlet üniversitesinin hemşirelik fakültesinde eğitim gören 135 hemşirelik öğrencisi oluşturdu. Araştırma verileri “Tanıtıcı Bilgi Formu” ve “Oyun Deneyimi Ölçeği” ile toplandı. Ölçeğin geçerlik ve güvenirlik çalışması kapsamında, dil, kapsam ve yapı geçerliği ile güvenirlik analizleri yapıldı.
Bulgular: Çeviri-geri çeviri tekniği ile dil geçerliği yapılan ölçeğin kapsam geçerlik indeksi 1.0’dir. GAMEX, 27 maddeden ve 6 alt boyuttan (toplam varyansın %78,13’ünü açıklar) oluşmaktadır. Doğrulayıcı faktör analizinden elde edilen uyum indeksleri değerlerine göre ölçeğin iyi uyum düzeyine sahip olduğu saptandı. Güvenirlik analizi sonuçlarına göre, ölçeğin tümüne yönelik Cronbach alfa değerinin 0,93; alt boyutlara yönelik Cronbach alfa değerlerinin ise 0,67 ile 0,929 arasında değiştiği bulundu. Ölçeğin tekrarlanabilirlik ve zamana karşı güvenirliğini değerlendirmek için iki hafta ara ile yapılan uygulamalar arasında ölçek toplam puanları arasındaki farkın anlamlı olmadığı (t=1.033, p=0.309) ve her iki ölçüm arasında pozitif yönde güçlü bir ilişki olduğu saptandı (r=0.484, p=0.003).
Sonuç: Araştırmadan elde edilen sonuçlar doğrultusunda ölçeğin oyun deneyimini değerlendirmede geçerli ve güvenilir bir ölçüm aracı olduğu belirlendi.
The history of the joint-stock company “Russian Standard” and its impact on the development of the city of Novorossiysk
Authors: Alekseev Vasiliy , Kolesnikov Ilya , Kasparyan Konstantin , Shavlokhova Elena , Petrova Sofya
Published: February 2024

In a scientific article, the authors examine the history and characteristics of the activities of the joint-stock company “Russian Standard”, as well as its impact on the development of the intracity district “Standard” in Novorossiysk. An analysis of the sources and facts available on this topic is carried out, with the help of which the problem of the development of the oil field in the Kuban and Southern Russia in the late 19th and early 20th centuries is revealed.
UKRN Institutional tasks implied by the UK Open Research Data Concordat
Authors: Network Reproducibility , Jacobs Neil , McCutcheon Valerie , Horton Laurence , Lister Allyson , Davidson Joy , Motes Alice , Partridge Adam Michael , Donaldson Mary
Published: February 2024

This UKRN working paper outlines the tasks that are either explicitly or implicitly proposed for research institutions by the UK Open Research Data Concordat (2016). It also reflects on how those tasks are relevant to the recommendations from the 2018 report issued by the UK Government from the Open Research Data Task Force. The aim of this paper is to describe more clearly what UK research institutions might be expected to do to support open research data, which may be a helpful basis for sector-wide discussion on both those expectations and how they are being met. The tasks are grouped under the headings of organisational support, infrastructure, recognition, restrictions on open data, costs, and strategy.