bluuebunny/crossref_metadata_2025 huggingface dataset:
Efficacy of semaglutide: an evidence-based review
Authors: Mkrtumyan A. M. , Egshatyan L. V.
Published: December 2022

Type 2 diabetes mellitus (T2DM) dominates the chronic non-communicable disease pandemics by its exceptionally rapid expansion into communities all over the world. In many countries diabetes is a socially significant disease. According to the data over the past decade, the number of people with T2DM has more than doubled globally. Equally disturbing is the fact that there are more than 250 million people with undiagnosed T2DM and more than 300 million with prediabetes. For 2045, it was estimated by the International Diabetes Federation that 693 million people will have diabetes. T2DM is a disorder of complex nature that urges further dedicated studies and ingenuity in the search for novel therapeutic approaches and on the pathogenetic links of disease. Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in people with T2DM, and diabetes itself confers a substantial independent risk of coronary heart disease, stroke, and death from other vascular causes. The article discusses an urgent challenge of modern healthcare – the role of new class of sugar-lowering drugs (exogenously administered glucagon-like peptide-1 receptor agonists (arGLP-1)) semaglutide in reducing the risk of developing cardiovascular complications. The authors paid attention to the main results of SUSTAIN clinical program and use as initial treatment for patients with T2DM with very high risk indicated in the new European guidelines with a view to get additional advantages in terms of life prognosis.
Investigation of Factors Affecting the Child-Rearing Attitudes of Mothers and Fathers With CHAID Analysis
Authors: Kalaylı Abdulkadir , Gültekin Akduman Gülümser , Özyürek Arzu
Published: December 2022

This research is on the relationship between mothers and fathers in child-rearing attitudes, and parents' child-rearing was conducted to examine the variables that affect attitudes. The research study group in the relational screening model consisted of the mothers and fathers of 324 children (n=648) 36-72 months old children attending preschool education institutions. The Parent Child-Rearing Attitudes Scale ((PAS) A form was used as a data collection tool in the study. Spearman-Brown Correlation Coefficient and CHAID algorithm, one of the decision tree algorithms, were used to analyse the data. As a result of the research, it was determined that democratic attitudes of mothers decrease and repressive-authoritarian attitudes increase as their over-tolerant attitudes towards their children increase; democratic attitudes of fathers decrease as their over-tolerant attitudes towards their children rise, and their democratic attitudes increase as their repressive-authoritarian attitudes increase. Again, it was determined that there is a positive and significant relationship between parents' child-rearing attitudes. It has been determined that the most important factors affecting the parenting attitudes of the parents are the birth order of the children, the education level of the mother, the education level of the father, the working status of the mother and the family structure.
Update on Mesenchymal Stem Cells: A Crucial Player in Cancer
Immunotherapy
Authors: Taeb Shahram , Rostamzadeh Davoud , Mafi Sahar , Mofatteh Mohammad , Zarrabi Ali , Hushmandi Kiavash , Safari Arash , Khodamoradi Ehsan , Najafi Masoud
Published: December 2022

The idea of cancer immunotherapy has spread, and it has made tremendous
progress with the advancement of new technology. Immunotherapy, which serves
to assist the natural defenses of the body in eradicating cancerous cells, is a remarkable
achievement that has revolutionized both cancer research and cancer treatments.
Currently, the use of stem cells in immunotherapy is widespread and shares a
special characteristic, including cancer cell migration, bioactive component release,
and immunosuppressive activity. In the context of cancer, mesenchymal stem cells
(MSCs) are rapidly being identified as vital stromal regulators of tumor progression.
MSCs therapy has been implicated in treating a wide range of diseases, including bone
damage, autoimmune diseases, and particularly hematopoietic abnormalities, providing
stem cell-based therapy with an extra dimension. Moreover, the implication of
MSCs does not have ethical concerns, and the complications known in pluripotent and
totipotent stem cells are less common in MSCs. MSCs have a lot of distinctive characteristics
that, when coupled, make them excellent for cellular-based immunotherapy
and as vehicles for gene and drug delivery in a variety of inflammations and malignancies.
MSCs can migrate to the inflammatory site and exert immunomodulatory responses
via cell-to-cell contacts with lymphocytes by generating soluble substances. In the
current review, we discuss the most recent research on the immunological characteristics
of MSCs, their use as immunomodulatory carriers, techniques for approving MSCs
to adjust their immunological contour, and their usages as vehicles for delivering therapeutic
as well as drugs and genes engineered to destroy tumor cells.
Serum Sirtuin-1, HMGB1-TLR4, NF-KB and IL-6 Levels in Alzheimer’s:
The Relation Between Neuroinflammatory Pathway and Severity of
Dementia
Authors: Gulmammadli Nazrin , Konukoğlu Dildar , Merve Kurtuluş Eda , Tezen Didem , Ibrahim Erbay Muhammed , Bozluolçay Melda
Published: December 2022

aims:

We aimed to investigate the inflammatory pathways that lead to progressive neuronal loss and highlight their possible relationship with dementia severity by detecting these molecules in the systemic circulation.

background:

Since neuronal loss and neuropathological lesion formation reach an irreversible stage by the time of diagnosis, symptomatic treatments that are applied can only offer modest clinical outcomes. This necessitates the search for a marker or tool to diagnose and monitor the process accurately and easily.

objective:

In this study, serum Sirtuin-1(SIRT-1), High Mobility Group Box 1 (HMGB1), Toll-Like Receptor-4 (TLR4), Nuclear Factor kappa B (NF-kB), Interleukine-6 (IL-6), Amyloid βeta-42 (Aβ-42), and p-tau181 levels in patients diagnosed with AD according to NINCS-ADRA criteria were studied.

method:

Patients over 60 years of age were grouped according to their Standard Mini Mental Test, MRI, and/or Fludeoxyglucose positron emission tomography or according to their Computed Tomography findings as Control n:20; AD n:32; Vascular Dementia (VD) n:17; AD+VD;n=21. Complete blood count, Glucose, Vitamin B12, Folic Acid, Enzymes, Urea, Uric Acid levels, Creatinine, Electrolytes, Bilirubin, Thyroid Function tests, and Sedimentation rate were evaluated. ELISA kit method was used for the analysis of serum SIRT1, HMGB1, TLR4, NF-kB, IL-6, Aβ-42, and p-tau181 levels.

result:

Levels of serum Aβ-42, SIRT1, HMGB1, and IL-6 were significantly higher (p˂0.001, p&lt;0.01, p&lt;0.001, and p&lt;0.001, respectively), and TLR4 levels were significantly lower (p˂0.001) in the dementia group than in the control group. There was no significant difference between dementia and control groups for serum NF-kB and p-tau181 levels.

conclusion:

Our results show that the levels of the Aβ42, SIRT 1, HMGB1, and TLR4 pathways are altered in AD and VD. SIRT 1 activity plays an important role in the inflammatory pathway of dementia development, particularly in Alzheimer's disease.

other:

This work is financially supported by Cerrahpaşa Scientific Research Projects Coordination Unit (BAPSİS)
Synthesis, ADMET Prediction, and Antitumor Profile of Phenoxyhydrazine-
1,3-thiazoles Derivatives
Authors: Leite Ana Cristina Lima , de Siqueira Lucianna Rabelo  Pessoa , de Lima Ferreira Larissa Pelágia , de  Oliveira Filho Gevanio Bezerra , de  Oliveira Marcos Victor Gregório , Pinto Aline Ferreira , de Melo  Silva Vanessa Gouveia , de Moraes Gomes Paulo André Teixeira , de Oliveira Cardoso Marcos Veríssimo , de Nazaré Correia Soeiro Maria , dos  Santos Flaviana Alves , da Rocha Pitta Maíra Galdino , Nunes Janine Siqueira , de Melo Rego Moacyr Jesus Barreto
Published: December 2022

Background:

Cancer is one of the most important barriers to increasing life expectancy in all countries in the 21st century. Investigations of new anti-cancer drugs with low side effects are an urgent demand for medicinal chemists. Considering the known antitumor and immunomodulato-ry activity of thiazoles, this work presents the synthesis and antineoplastic activity of new thiazoles.

Method:

The 22 new compounds (2a-v) were synthesized from different thiosemicarbazones and 2-bromoacetophenone. The compounds were evaluated on: MOLT-4, HL-60, HL-60/MX1, MM1S, SKMEL-28, DU145, MCF-7, and T47d.

Result:

Compound 2b induced cellular viability on MOLT-4 (37.1%), DU145 (41.5%), and HL-60/MX1 (58.8%) cells. On MOLT-4 cells, compound 2b exhibited an IC50 of 8.03 μM, and against DU145 cells, an IC50 of 6.04μM. Besides, at IC50 and fold of IC50, 20% to 30% of dead cells were found, most due to necrosis/late apoptosis. Most compounds no showed cytotoxicity against fibro-blast cells L929 at the concentrations tested. The compound did not alter the cell cycle of DU145 cells when compared to the negative control. Therefore, compound 2b stands out against DU145 and MOLT-4 cells.

Conclusion:

Our study reinforced the importance of 1,3-thiazoles nuclei in antitumor activity. In addition, derivative 2b stands out against DU145 and MOLT-4 cells and could be a starting point for developing new antineoplastic agents.
Piezoelectric Biosensors and Nanomaterials-based Therapeutics for Coronavirus
and Other Viruses: A Mini-review
Authors: Bhaskar Rakesh , Han Sung Soo , Ramasamy Madeshwaran Sekkarapatti
Published: December 2022

Since late 2019, the novel coronavirus (COVID-19) pandemic has caused considerable mortality worldwide. This pandemic raised concerns and provoked research on the diagnosis and treatment of viruses-based diseases. The accurate diagnosis of a virus requires high specificity and sensitivity. Piezoelectric sensors are analytical devices that work on mass-sensitivity-based micro-mechanical transducers. The change in the mass by the interaction between biological elements and the frequency is recorded by measuring the alternate current and voltage. In addition to diagnosis, antiviral intervention strategies for mitigating various viral diseases are required. Nanomaterials-based antiviral therapy is efficient, particularly with carbon/metal/metal oxide (organic/inorganic) nanoparticles. Metal/metal oxide nanoparticles, such as gold (Au), silver (Ag), copper (Cu), seleni-um (Se), zinc oxide (ZnO), magnesium oxide (MgO), carbon dots (CDs), and carbon quantum dots (CQDs), are promising candidates for antiviral therapy. This review discusses the piezoelectric sen-sors used to detect various viruses, including COVID-19, and the various organic and inorganic na-noparticles involved in the antiviral therapy.
Nutritional and Medicinal Value of Red Rice
Authors: Kothapalli Lata , Kale Sakshi , Dharade Monika , Thomas Asha , Godse Anagha
Published: December 2022

Background:

Various varieties of rice (Oryza sativa) have been exploited for a variety of
purposes since ancient times, with the integration into foods, cosmetics, and pharmaceutical products.
A huge diversity is seen in the cultivated rice variety based on regions, area, and climatic conditions
responsible for variation in chemical composition leading to enriched supplements beneficial
for health conditions. Among the varieties available, red rice extract is now increasingly recognized
for its antioxidant, anti-inflammatory activity, anti-diabetic, anti-hyperlipidemic activity, and bone
formation.

Objective:

There is a need to validate the nutritional and supplement values through appropriate analytical
and pharmacological studies and create awareness for the end users regarding the value of
red rice.

Results:

In the present article attempt is done to reviewthe variety of red rice based on geographical
origin, and the impact on nutritional and medicinal value. Further elaborating the extraction techniques
which can help optimize the extraction efficiency of polyphenols known for their antioxidant
properties. Polyphenolic phytoconstituents belonging to phenolic acids, and flavonoids include, flavonols,
flavones, flavanols, flavanones, and isoflavones, to name a few. Anthocyanins, and proanthocyanidins
make the pigment part of the outer layer and bran of the rice and contain the monomers
of catechin, epicatechin, gallocatechin, and epigallocatechin units. The quantification of the
phytoconstituents using chromatographical methods can help in evaluation of the red rice for its
quality and design formulation with desired efficacy.

Conclusion:

With the vast varieties of red rice available, quantification of important bio-actives
can help in maintaining quality of final product. Various targeted pharmacological actions reported
include anti-inflammatory, antihyperlipidemic, antidiabetic, anticancer and antioxidant produced by
the rice, mainly by virtue of the polyphenolic content, contribute in achieving a value to rice as
nourishment and a safe therapeutic product which can be consumed as a nutraceutical or pharmaceutical
ingredient.
Analisis Keruntuhan Bendungan Rukoh Kabupaten Pidie Menggunakan Aplikasi HEC-RAS dan Berbasis InaSAFE
Authors: Khairi Muhammad Ariq Fathyan , Suprijanto Heri , Hendrawan Andre Primantyo
Published: December 2022

Bendungan Rukoh memiliki tampungan efektif sebesar 125,7 juta m3 dengan tujuan utama untuk optimalisasi pemenuhan kebutuhan air irigasi, dan untuk pengendalian banjir Kabupaten Pidie. Dibalik manfaatnya yang besar, bendungan berpotensi membahayakan keamanan publik apabila terjadi keruntuhan bendungan. Ketika terjadi keruntuhan bendungan, air dalam jumlah besar pada waduk dapat mengakibatkan banjir yang cepat dan tiba-tiba, mengakibatkan kerugian nyawa serta kerusakan material yang masif. Tujuan studi ini adalah untuk mengetahui dampak maksimum yang dapat terjadi dari berbagai macam skenario keruntuhan bendungan pada Bendungan Rukoh. Menggunakan data populasi regional, kerugian ekonomi akibat keruntuhan bendungan kemudian dihitung. Keruntuhan Bendungan Rukoh disimulasikan menggunakan program HEC-RAS v5.0.7 dengan basis data geometri yang tersedia, kemudian dihitung kerugian ekonominya dengan bantuan aplikasi InaSAFE. Hasil simulasi menunjukkan puncak debit banjir rancangan Probable Maximum Flood (PMF) dengan Qinflow sebesar 517,102 m3/detik tidak mengakibatkan skenario overtopping. Dari hasil simulasi, keruntuhan Bendungan Rukoh oleh skenario piping tengah kondisi muka air banjir menghasilkan dampak paling besar dengan ketinggian air maksimum sebesar 21,94 m dengan luasan banjir melingkupi 237,409 km2. Angka-angka tersebut menandakan bahwa keruntuhan Bendungan Rukoh dikategorikan sebagai bahaya tingkat tinggi. Estimasi kerugian ekonomi akibat keruntuhan Bendungan Rukoh menggunakan program InaSAFE adalah sebesar Rp. 573.068.311.480.
Studi Laju Infiltrasi Menggunakan Model Horton dan Model Philip pada Berbagai Tutupan Lahan
Authors: Suteja Yanuarning Tyas Dwi Safitri , Harisuseno Donny , Wahyuni Sri
Published: December 2022

Pesatnya pembangunan dalam menunjang kebutuhan manusia di DAS Lesti semakin mempersempit lahan yang memungkinkan untuk infiltrasi. Studi ini bertujuan untuk membandingkan dua model laju infiltrasi dengan menggunakan model Horton dan Model Philip pada berbagai tutupan lahan sehingga didapatkan metode yang paling sesuai yang dapat diterapkan pada DAS Lesti. Penelitian dilakukan di delapan titik lokasi yang tersebar di DAS Lesti dengan empat tutupan lahan yaitu pemukiman, vegetasi, pertanian, dan lahan terbuka. Pengukuran laju infiltrasi dilakukan dengan menggunakan alat Double Ring Infiltrometer. Penelitian ini menunjukkan bahwa lahan terbuka memiliki laju infiltrasi sangat cepat, sedangkan lahan pertanian memiliki laju infiltrasi lambat. Setelah dilakukan analisis menggunakan model Horton dan model Philip didapatkan laju infiltrasi maksimum pada model Horton sebesar 10,038 mm/menit pada lahan terbuka dan laju infiltrasi minimum sebesar 2,203 mm/menit pada lahan pertanian, sedangkan pada model Philip laju infiltrasi maksimum sebesar 15,125 mm/menit pada lahan terbuka dan laju infiltrasi minimum sebesar 3,063 mm/menit pada lahan pertanian. Berdasarkan nilai MAE, NSE, dan kesalahan relatif, model infiltrasi Horton lebih baik dalam memprediksi laju infiltrasi di DAS Lesti.
Studi Perencanaan Ulang Bendung di Daerah Irigasi Rawaan Kabupaten Lumajang Jawa Timur
Authors: Purwanto Harjuna Arif , Suprijanto Heri , Prayogo Tri Budi
Published: December 2022

Bendung Rawaan merupakan bangunan utama yang berperan memenuhi kebutuhan air lahan irigasiÂ  seluas 354,10 ha di Daerah Irigasi Rawaan. Rusaknya sebagian besar dari Bendung Rawaan menyebabkan lahan irigasi seringkali tidak terairi sepenuhnya, terutama saat musim kemarau. Untuk mengoptimalkan fungsi bangunannya, maka diperlukan perencanaan ulang berdasarkan analisis hidrologi, hidrolika, stabilitas, dan desain penulangan. Dimensi bangunan utama Bendung Rawaan ditentukan berdasarkan analisis hidrologi debit banjir kala ulang 100 tahun (Q100) HSS Gama I sebesar 318,51 m3/detik. Direncanakan dimensi mercu Bendung Rawaan memiliki tinggi 1,60 m dan lebar 25,60 m. Peredam energi menggunakan tipe bucket untuk mencegah terjadinya kerusakan peredam energi akibat gaya hantam dari sedimen sungai berupa batuan bolder. Berdasarkan desain hidrolis, pemilihan tipe bucket juga mengurangi kemungkinan terjadinya gerusan lokal di hilir bangunan. Keamanan struktur bangunan dinyatakan aman berdasarkan analisis rembesan dan stabilitas dalam keadaan normal dan gempa. Bendung Rawaan didesain menggunakan beton K-175 yang dilapisi selimut beton bertulang K-300.
Studi Alternatif Perencanaan Rainwater Harvesting Pada Apartemen Westpoint Jakarta Barat
Authors: Maulana Firhand , Haribowo Riyanto , Sholichin Moh.
Published: December 2022

Penelitian ini bertujuan untuk mengetahui berapa potensi air hujan yang dapat digunakan sebagai alternatif sumber air pada Apartemen Westpoint dan juga merencanakan anggaran biaya pada perencanaan pemanenan air hujan di Apartemen Westpoint. Pada penelitian ini untuk area tangkapan air hujan menggunakan 3 area. Dari hasil 3 area tangkapan maka diperoleh air hujan yang dapat di tampung pada Apartemen Westpoint yaitu sebesar 34 m3/hari dengan luas area tangkapan sebesar 1,500 m2. Tampungan pada perencanaan ini menggunakan 2 tampungan yaitu ground water tank dan roof tank dengan masing-masing kapasitasnya sebesar 34 m3 dan 4.6 m3. Pada perhitungan kebutuhan air berdasarkan jenis alat plambing pada lantai 1 sampai 3Â  didapatkan sebesar 17,366 m3/hari Setelah dilakukan analisa maka kebutuhan air untuk kegiatan menyiram toilet dan bak cuci tangan biasa pada lantai 1 sampai 3 dapat terpenuhi, dengan penghematan sebesar Rp 217.868 / hari yang akan menguntungkan pihak pengelola Apartemen Westpoint. Sedangkan untuk rancangan anggaran biaya perencanaan pemanenan air hujan pada Apartemen Westpoint ini sebesar Rp 292.471.563.
Analisis Hujan TRMM (Tropical Rainfall Measuring Mission) menjadi Debit dengan Metode F.J. Mock pada DAS Bango
Authors: Ilham Muhammad , Suhartanto Ery , Fidari Jadfan Sidqi
Published: December 2022

Keterbatasan data hujan maupun data debit menjadi masalah umum dalam analisis hidrologi. Adanya data satelit meteorologi TRMM dapat memberikan alternatif data hujan spasial yang kemudian dapat dialihragamkan menjadi data debit menggunakan permodelan metode F.J. Mock. Studi ini berlokasi di DAS Bango dengan tujuan mengetahui hasil kalibrasi dan validasi data TRMM serta debit model F.J. Mock terhadap data lapangan. Kalibrasi TRMM dilakukan dengan menggunakan persamaan regresi terpilih untuk mengkoreksi data, sedangkan kalibrasi debit model F.J. Mock dengan menentukan parameter yang mempengaruhi model agar sesuai debit lapangan. Validasi menggunakan parameter statistik Root Mean Squared Error (RMSE), Nash Sutcliffe Efficiency (NSE), Kesalahan Relatif (KR), dan Koefisien Korelasi (R). Hasil kalibrasi dengan TRMM terkoreksi terbaik pada data 9 tahun dengan validasi terbaik pada data 4 tahun ditunjukkan NSE=0,817. Hasil kalibrasi debit model F.J. Mock terbaik pada data 5 tahun dengan validasi terbaik pada data 1 tahun ditunjukkan NSE=0,712. Alihragam TRMM menjadi debit metode F.J. Mock dengan kisaran nilai i=0,20; k=0,55-0,65; ISM=19-76 mm; m=31%; SMC=200 mm. Dari keseluruhan analisis, dapat disimpulkan data debit model F.J. Mock dari hujan TRMM dapat digunakan untuk memprediksi data debit lapangan karena menghasilkan nilai yang mendekati.
Aplikasi Stability Chart untuk Idealisasi Desain Tanggul Kali Lamong di Kabupaten Gresik, Provinsi Jawa Timur
Authors: Sanwa Niken Wibasari , Hendrawan Andre Primantyo , Asmaranto Runi
Published: December 2022

Keruntuhan tanggul adalah salah satu kecelakaan di bidang teknik yang menyebabkan bencana banjir. Hal tersebut disebabkan karena proses perencanaan yang tidak benar sehingga tidak memenuhi persyaratan teknis. Salah satu kasusnya terjadi di Kali Lamong, Jawa Timur. Kali Lamong memiliki permasalaan banjir yang disebabkan oleh keruntuhan tanggul hampir setiap tahunnya. Tujuan dari studi ini yaitu adanya suatu pedoman yang digunakan untuk merencanakan struktur tanggul yang aman dan bertahan lama. Dengan bantuan grafik sederhana disebut stability chart yang memiliki hubungan antara nilai faktor keamanan dengan dimensi tanggul. Studi ini menggunakan dua parameter, yaitu parameter dimensi dan parameter jenis tanah. Untuk parameter jenis tanah dibagi lagi menjadi empat variasi jenis tanah berdasarkan nilai parameternya. Setelah diinput ke dalam aplikasi geostudio 2018 didapatkan bahwa desain variasi I dan III dinyatakan aman sedangkan variasi II dan IV tidak aman. Desain yang tidak aman tersebut dibutuhkan perkuatan sehingga ditambahkan berm dan pile dan menghasilkan semua variasi dinyatakan aman. Maka penggunaan berm dan pile sebagai perkuatan dinyatakan efektif untuk meningkatkan nilai faktor keamanan.
Impact of the COVID-19 Pandemic on the Standard of Living of the B40 Group
Authors: Ibhrim Zuriani , Zur Raffar Izzah Nur Aida , Abdul Aziz Suhaila , Dzaky Ahmad
Published: December 2022

This study aims to identify the impact of COVID-19 on the standard of living of B40, which involves issues of income, expenditure, and saving between the urban and rural parts of the Klang Valley. This study uses a cross-sectional survey research design. Six hundred fifty respondents from B40 households were selected to answer the questionnaire, and the data were analyzed using Mann-Whitney U inference test statistics. The results found no significant difference between those from urban and rural areas of the B40 group on the impact of living standards during the implementation of the Movement Control Order (MCO).
Keywords: Impact, COVID-19, Standard of Living B40, Klang Valley
eISSN: 2398-4287 Â© 2022. The Authors. Published for AMER ABRA cE-Bs by e-International Publishing House, Ltd., UK. This is an open access article under the CC BYNC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Peerâ€“review under responsibility of AMER (Association of Malaysian Environment-Behaviour Researchers), ABRA (Association of Behavioural Researchers on Asians/Africans/Arabians) and cE-Bs (Centre for Environment-Behaviour Studies), Faculty of Architecture, Planning & Surveying, Universiti Teknologi MARA, Malaysia.
DOI: https://doi.org/10.21834/ebpj.v7i22.4034
Environmental Transmission by the Mountain Dwellers: Case of the Moroccan Middle-Atlas Women
Authors: Iflahen Fatima-Zohra , Benkhallouq Fatima Ez-zahra
Published: December 2022

The role of indigenous people in the preservation and transmission of local knowhow and wisdom is well documented. In its different aspects, storytelling is the most important form of expression reflecting the essence of the Amazigh (native) population in the Middle Atlas. Amazigh storytelling displays several social indicators and modes of capturing the world and its resources, crystallizing representations that highlight a shared culture transmitted from one generation to another. Spoken language is an omnipresent instrument for concluding acts, establishing pacts, and preserving natural heritage through the likes of proverbs, tales, myths, focusing on central societal activities such as: harvesting, plowing, threshing, sheep mowing, wool work, milk processing, weaving, wedding ceremonies, etc. Amazigh women more often than not tend to act as the living repositories of this culture. Their strong ties with their close environment, the sustainability knowledge that they pass from one generation to another, and their strong resilience capacity has been observed, studied, and recognized in other environments. Based on conversations, life stories, and testimonies of men and women, and observation of different practices and rituals led by women, we managed to closely examine a feminine faunal and floral knowledge and showcase this homogeneous and solid structure labeled “woman knowledge”. This article thus aims to report the transmission within this environment and the role of Amazigh women in the sustainability of local knowledge.
Keywords: Environment; Local; Transmission; Amazigh-women
eISSN: 2398-4287 © 2022. The Authors. Published for AMER ABRA cE-Bs by e-International Publishing House, Ltd., UK. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Peer–review under responsibility of AMER (Association of Malaysian Environment-Behaviour Researchers), ABRA (Association of Behavioural Researchers on Asians/Africans/Arabians) and cE-Bs (Centre for Environment-Behaviour Studies), Faculty of Architecture, Planning & Surveying, Universiti Teknologi MARA, Malaysia.
DOI: https://doi.org/10.21834/ebpj.v7i22.4178
Парамагнитные центры ванадия и железа в монокристалле Na-=SUB=-5-=/SUB=-AlF-=SUB=-2-=/SUB=-(PO-=SUB=-4-=/SUB=-)-=SUB=-2-=/SUB=-
Authors: Важенин В.А. , Фокин А.В. , Потапов А.П. , Артёмов М.Ю.
Published: December 2022

Исследовано ориентационное поведение ЭПР-переходов неконтролируемых примесных центров V4+ (S=1/2) и Fe3+ (S=5/2) в монокристалле Na5AlF2(PO4)2, легированном хромом. Определены параметры спинового гамильтониана этих центров как в лабораторной (кристаллографической), так и в локальной системах координат. Основываясь на факте существования смешанных ванадат-фосфатов и учитывая ориентацию главной оси V4+ сделан вывод о замещении ванадием позиции фосфора. Обнаружена близость главных осей тензоров тонкой структуры второго и четвертого ранга центров Fe3+ к направлению F-F фтор-кислородного октаэдра, окружающего ион железа. Ключевые слова: примесные ионы, парамагнитный резонанс, сверхтонкое взаимодействие.
Молекулярно-динамические исследования процесса кристаллизации и роста газовых гидратов в сильно переохлажденной двухфазной системе "метан-вода"
Authors: Хуснутдинов Р.М. , Хайруллина Р.Р. , Юнусов М.Б.
Published: December 2022

The processes of nucleation and growth of methane hydrate in a highly supercooled two-phase methane–water system obtained using various cooling protocols are considered. It has been shown that, at sufficiently high cooling rates, crystalline forms of methane hydrate can still form in the system. It was found that, at a cooling rate of γ = 1.0 K/ps, the process of nucleation and growth of gas hydrate was observed in all independent molecular dynamics iterations, while at a cooling rate of γ = 10.0 K/ps, no nucleation event was observed in ~26.7% of numerical experiments. It was found that with an increase in the cooling rate of the system, an increase in the average time scale of nucleation τc and a decrease in the critical size of the nucleus nc are observed. It is shown that at a sufficiently deep level of supercooling of the system, the scenario of homogeneous crystalline nucleation is realized at the initial stage of the phase transition.
Лазерно-индуцированный графен и его модификация полипирролом для увеличения емкости микросуперконденсатора
Authors: Михеев К.Г. , Сюгаев А.В. , Зонов Р.Г. , Булатов Д.Л. , Михеев Г.М.
Published: December 2022

Laser-induced graphene (LIG) films were synthesized by line-by-line scanning of continuous CO2 laser focused radiation on the surface of industrial polyimide film as a result of pyrolysis of its near-surface layer. The structure of the synthesized film material is shown to be heterogeneous in thickness by Raman spectroscopy. The results of the study of the effect of the laser power and the distance between the lines on the specific electrical capacitance c of the synthesized material in aqueous solution of sulfuric acid are presented. It is shown that modification of LIG with polypyrrole (PPy) allows to increase c from up to 60 mF/cm2. PPy-modified LIG films were used to make a prototype of a flexible film microsupercapacitor with an area of 8 cm2 with a gel electrolyte based on sulfuric acid and polyvinyl alcohol with a 230 mF capacitance.
Perspectives on Promoting Physical Activity Using eHealth in Primary Care by Health Care Professionals and Individuals With Prediabetes and Type 2 Diabetes: Qualitative Study
Authors: Woldamanuel Yohannes , Rossen Jenny , Andermo Susanne , Bergman Patrik , Åberg Linda , Hagströmer Maria , Johansson Unn-Britt
Published: December 2022

Background

The trend of an exponential increase in prediabetes and type 2 diabetes (T2D) is projected to continue rising worldwide. Physical activity could help prevent T2D and the progression and complications of the disease. Therefore, we need to create opportunities for individuals to acquire the necessary knowledge and skills to self-manage their chronic condition through physical activity. eHealth is a potential resource that could facilitate self-management and thus improve population health. However, there is limited research on users’ perception of eHealth in promoting physical activity in primary care settings.

Objective

This study aims to explore the perspectives of health care professionals and individuals with prediabetes and T2D on eHealth to promote physical activity in primary care.

Methods

A qualitative approach was applied using focus group discussions among individuals with prediabetes or T2D (14 participants in four groups) and health care professionals (10 participants in two groups). The discussions were audio-recorded and transcribed verbatim. Qualitative content analysis was used inductively to code the data.

Results

Three main categories emerged: utility, adoption process, and accountability. The utility of eHealth was described as a motivational, entertaining, and stimulating tool. Registration of daily medical measurements and lifestyle parameters in a cohesive digital platform was recognized as a potential resource for strengthening self-management skills. The adoption process includes eHealth to increase the accessibility of care and personalize the support of physical activity. However, participants stated that digital technology might only suit some and could increase health care providers’ administrative burden. Accountability refers to the knowledge and skills to optimize eHealth and ensure data integrity and security.

Conclusions

People with prediabetes and T2D and health care professionals positively viewed an integration of eHealth technology in primary care to promote physical activity. A cohesive platform using personal metrics, goal-setting, and social support to promote physical activity was suggested. This study identified eHealth illiteracy, inequality, privacy, confidentiality, and an increased workload on health care professionals as factors of concern when integrating eHealth into primary care. Continuous development of eHealth competence was reported as necessary to optimize the implementation of eHealth technology in primary care.
Development of Open Backend Structures for Health Care Professionals to Improve Participation in App Developments: Pilot Usability Study of a Medical App
Authors: Dittrich Florian , Albrecht Urs-Vito , Scherer Julian , Becker Sören L , Landgraeber Stefan , Back David Alexander , Fessmann Kai , Haversath Marcel , Beck Sascha , Abbara-Czardybon Mona , Quitmann Henning , Harren Anna Katharina , Aitzetmüller Matthias , Klietz Marie Luise
Published: December 2022

Background

Efficient digitization in medicine still is in its infancy but undeniably has great potential for current and future challenges in health care. Thus far, the rollout of medical apps has not resulted in widespread use of smartphones in the German health care sector—the reasons for this have not been clarified so far. Nevertheless, the lack of user involvement in the development process and content creation might contribute to low acceptance of these products.

Objective

This study aims to outline an approach to involve medical expertise without any coding knowledge for developing medical app content and functions.

Methods

An end user–operable backend was built. Its usability was evaluated using a usability evaluation test protocol. The results of the usability tests were evaluated by the app development team, and the usability test was repeated for optimizing backend usability. In total, 40 criteria to measure the ease of app usage were defined a priori. The usability test comprised 20 tasks that had to be fulfilled. Usability tasks were analyzed for completion, dropout, and test duration. Due to the COVID-19 pandemic, digital videoconferencing platforms (Zoom and QuickTime Player) were used to complete usability questionnaires. Finally, several backend-based apps for several specialties (infectiology, plastic and reconstructive surgery, and orthopedics) were developed by health care professionals as prototypes.

Results

Initial usability testing was conducted with 5 participants (4 men and 1 woman; mean age 39.2, SD 5.97 years). All of them could complete the assigned backend tasks with only a few workflow interruptions and some minor errors. After usability optimization, the workflow completion time decreased from 5.03 minutes to 3.50 minutes, indicating a time saving. The basic backend structure was clear to all test users and the handling was intuitive to learn. Some minor errors in the backend occurred during the test rounds. The apps developed using the aforementioned approach are in clinical use as a proof of concept.

Conclusions

Backends offering operability for medical professionals might have great potential for app development in the mobile health sector. Sophisticated and time-saving usability are pivotal for the acceptance of medical software, as illustrated by the backend-based apps presented herein, which are in clinical use as a proof of concept. Basic interventions are essential and sufficient for adequate usability optimization. Practicable, well-structured software usability evaluation is possible based on the usability evaluation test protocol.
Повышение оперативности оценки возможностей средств телевизионной разведки
Authors: Леньшин А.В. , Кравцов Е.В. , Рюмшин Р.И. , Сидоренко И.А.
Published: December 2022

При телевизионной разведке уровень освещенности объектов и дальность
проведения оценки оптико-электронными приборами влияют на вероятности
обнаружения и распознавания объектов. Предложен методический подход,
позволяющий повысить оперативность оценки возможностей телевизионной разведки
на различных носителях с использованием значений коэффициентов яркости объектов разведки, фонов и покрытий, минимального размера объекта. Доказана приемлемая достоверность использования методики применительно к конкретным условиям.
Разработаны необходимые рекомендации по противодействию средствам телевизионной
разведки в условиях неудовлетворительного показателя разведдоступности.
Introducción de animales domésticos exóticos en la economía pastoril andina (ca. 440-500 AP). Un caso de estudio de Antofagasta de la Sierra, Catamarca, Puna Austral de Argentina
Authors: Navarrete Vanessa , Urquiza Silvana Valeria , Quiroga Laura , Puente Verónica
Published: December 2022

The introduction of exotic animals during the settlement of European populations in southern Argentine Puna was a turning point in the Andean pastoral economy. Research has shown that exotic domestic animals such as goats, swine and equidae were present in the initial stages of the early colonial period and that European goods were part of everyday life. This paper aims to characterize the handling and use of exotic domestic animals and the possibility that they were part of colonial-era economic strategies in this part of the Puna. Analysis of the faunal remains from the PP3-C site (ca. 440-500 AP), comprised of residential and productive structures at 3,600 meters above sea level, reveals that the remains of Capra a. hircus (89%) and Sus s. domesticus (6%) show marks of butchery and consumption. Equus sp. (5%) has also been documented. The introduction of exotic animals into agropastoral systems triggered changes in the human diet between the pre-colonial and early colonial periods. The introduction of goats, in particular, expanded herd husbandry practices in Antofagasta de la Sierra during the same period.
Axially Symmetric Perfect Fluid Cosmological Model in Modified Theory of Gravity
Authors: Kadam V P
Published: December 2022

Abstract: With an appropriate choice of the function f (R,T) , an anisotropic Axially Symmetric Space – time filled with perfect fluid in general relativity and also in the framework of f (R,T) gravity proposed by Harko et. al. (in arXiv: 1104. 2669 [grqc],2011) has been studied. The field equations have been solved by using the anisotropy features of the universe in Axially Symmetric Bianchi type- I Space – time. We have been discussed some physical properties of the models. We observed that the involvement of new function f (R,T) does not affect the geometry of the space-time but slightly changes the matter distribution.
Fuzzy Rule-Based Clustering Algorithm for Energy Efficiency in WSN
Authors: Thakur Harish , Ganpati Dr. Anita
Published: December 2022

Abstract: Wireless Sensor Networks (WSNs) have gained much attention in public and research communities due to their incredible capabilities and ever-growing range of applications. The WSN is equipped with a specialized transducer that adds sensing services to IoT. This equipment is limited to battery and resource capacity, which introduces many challenges to academia and industry. Many recent wireless sensor networks (WSN) routing protocols are enhancements to address specific issues with the low-energy adaptive clustering hierarchy (LEACH) protocol. Low Energy Adaptive Clustering Hierarchy (LEACH) algorithm compensates for the energy flow in CH by probabilistically rotating the position between nodes with energy above the specified threshold. The selection of CH in WSN is NP-Hard as the optimal data aggregation with efficient energy efficiency cannot be resolved in polynomial time. Since the performance of LEACH deteriorates sharply with increasing network size, the challenge for new WSN protocols is to extend the network lifespan while maintaining high scalability. This paper introduces a fuzzy logic-based energy-efficient scalable routing algorithm (F-EESRA). The goal of the proposed algorithm is to extend the network lifespan despite an increase in network size. This paper compares F-EESRA against EESRA WSN routing protocol in terms of network performance. EESRA uses multi-hop transmissions for intra-cluster communications to implement the proposed work. The simulation results show that F-EESRA outperforms the fuzzy protocol in terms of energy efficiency on large-scale WSNs.
Cryptocurrency Price Prediction Using Linear Regression and Long Short-Term Memory (LSTM)
Authors: Dhande Atharva , Dhani Shoumyadeep , Parnami Shivang , Vijayakumar K. P.
Published: December 2022

Abstract: Predicting future events is difficult, particularly with regards to cryptocurrency, where the media, influential people and governments have a sharp and vital impact on worth. Cryptocurrency market analysis is a method through which the realworld data of the cryptocurrency market is used to predict where it will go next. If foretold accurately, it helps investors to invest when the value is low (purchasing in bulk when the price is dipping) and sell once it's high so as to gain a profit. This research provides two machine learning algorithms which are Long Short-Term Memory (LSTM) and Linear Regression for predicting the values of six different types of crypto currencies such as Bitcoin (BTC), Dash coin (DASH), Lite coin (LTC), Dogecoin (DOGE), Ethereum (ETH), and Monero (XMR). The accuracy of the models is analyzed using mean squared error.
Impact of Corporate Social Responsibility Activities Communicating About a Brand
Authors: Sawant Nisha , Naik Shubham
Published: December 2022

Abstract: Corporate social responsibility (CSR) is a type of international private business self-regulation that aims to contribute to societal goals of a philanthropic, activist, or charitable nature by engaging in or supporting volunteering or ethically-oriented practices. While once it was possible to describe CSR as an internal organisational policy or a corporateethic strategy, that time has passed as various international laws have been developed and various organisations have used their authority to push it beyond individual or even industry-wide initiatives. While it has been considered a form of corporate self-regulation forsome time, over the last decade or so it has moved considerably from voluntary decisions at the level of individual organizations to mandatory schemes at regional, national, and international levels. Considered at the organisational level, CSR is generally understood as a strategic initiative that contributes to a brand's reputation. As such, social responsibility initiatives must coherently align with and be integrated into a business model to be successful. With some models, a firm's implementation of CSR goes beyond compliance with regulatory requirements and engages in "actions that appear to further some social good, beyond the interests of the firm and that which is required by law”. Furthermore, businesses may engage in CSR for strategic or ethical purposes. From a strategic perspective, CSR can contribute to firm profits,particularly if brands voluntarily self-report both the positive and negative outcomes of their endeavours. In part, these benefits accrue by increasing positive public relations and high ethical standards to reduce business and legal risk by taking responsibility for corporate actions. CSR strategies encourage the company to make a positive impact on the environment and stakeholders including consumers, employees, investors, communities, and others. From an ethical perspective, some businesses will adopt CSR policies and practices because of ethical beliefs of senior management. For example, a CEO may believe that harming the environment is ethically objectionable
Comparison of the performance of GaussianNB Algorithm, the K Neighbors Classifier Algorithm, the Logistic Regression Algorithm, the Linear Discriminant Analysis Algorithm, and the Decision Tree Classifier Algorithm on same dataset
Authors: Sawant Nisha , Khadapkar Dnyandev Ravindra
Published: December 2022

Abstract: Most educational institutions worldwide have been closed since March 2020 in an effort to slow the spread of the Covid-19 epidemic. More than 90% of students around the world have been influenced by this. In this study, we'll make a prediction about whether or not the Covid-19 epidemic has benefited student performance. Our data will be divided into training and testing datasets, with 80% of the data utilised for training and 20% for testing. To calculate the accuracy of our predictions, we'll use six different algorithms, including the RandomForestClassifier Algorithm, the GaussianNB Algorithm, the K Neighbors Classifier Algorithm, the Logistic Regression Algorithm, the Linear Discriminant Analysis Algorithm, and the DecisionTree Classifier Algorithm.
Daily Mess: Mobile App Initiative to Uplift Mess Halls
Authors: Patil Shrishailappa , Bhadane Deven
Published: December 2022

Abstract: Eating on a college campus can be a challenge, especially when it comes to finding options that are both convenient and affordable. To address this issue, we have developed a mobile app called "Daily Mess" which allows college students to easily locate and browse food halls in their area. The app utilizes the user's current college location to provide a list of nearby food halls, along with information such as distance, price range, and type of cuisine. It is an assistive technology / app that will help local food businesses to increase their customer base and their reach among students. The app will allow business to register as a local mess hall and have options to edit and change different features of their mess halls in real-time. Overall, our app aims to provide college students with a convenient and efficient way to discover and visit food halls in their community.
Detección molecular de un fragmento del virus de lengua azul en borregos de diferentes regiones de México
Authors: Rojas Anaya Edith , Cerón-Téllez Fernando , Yáñez-Garza Luis Adrián , Gutiérrez-Hernández José Luis , Sarmiento-Salas Rosa Elena , Loza-Rubio Elizabeth
Published: December 2022

La enfermedad de la lengua azul (LA) afecta diferentes especies de rumiantes silvestres y domésticos. En México, la enfermedad producida por el virus de la lengua azul (VLA), aún es reconocida como exótica, a pesar de que, en diferentes ocasiones se han detectado anticuerpos. El objetivo fue establecer técnicas moleculares usando un gen sintético que incluye los genes NS1 y NS3 como control positivo para establecer el diagnóstico del VLA en muestras de ovinos de diferentes regiones del país, mediante técnicas moleculares. Se obtuvieron 320 muestras totales de sangre completa de ovinos. Las muestras obtenidas se evaluaron mediante RT-PCR punto final y RT-PCR en tiempo real estableciendo las condiciones por el grupo de trabajo. Se encontraron 12 muestras positivas de ovinos a la detección de NS1; estas muestras se secuenciaron obteniendo un fragmento de 101 pares de bases. Al realizar el alineamiento se obtuvieron identidades con secuencias reportadas en el GenBank con fragmentos de NS1 desde 89 % (p= 1e-12) a 98 % (p= 4e-13), correspondientes a los serotipos 10, 11 y 12.  De estas muestras, se obtuvieron dos muestras positivas de ovinos mediante el PCR tiempo real (PCR-tr), uno proveniente de Chiapas (raza Chiapas) y el otro de Tamaulipas (raza Suffolk). Los resultados de la PCRtr fueron corroborados por la CPA-SENASICA. Este trabajo, aporta por primera vez en México, la importancia de usar un gen sintético como control positivo, para realizar la detección en laboratorios oficiales BSL-2, lo cual en una emergencia sanitaria es de suma importancia.