bluuebunny/crossref_metadata_2025 huggingface dataset:
Isolated splenic vein thrombosis as a complication of abdominal trauma in a 3-month-old girl
Authors:   Department of Paediatrics and Nephrology, Medical University of Warsaw, Warsaw, Poland, Szmigielska Agnieszka , Krzemień Grażyna ,   Department of Paediatrics and Nephrology, Medical University of Warsaw, Warsaw, Poland, Rogala Magdalena Maria ,   Department of Paediatrics and Nephrology, Medical University of Warsaw, Warsaw, Poland, Jakimów-Kostrzewa Aleksandra ,   Department of Paediatric Radiology, Medical University of Warsaw, Warsaw, Poland
Published: October 2021

Falls from heights and traffic accidents are the most common causes of splenic damage. Abdominal trauma can cause splenic rupture or splenic vein thrombosis. About 11–55% of children with splenic vein thrombosis develop collateral circulation, leading to gastric and/or oesophageal varicose veins. Venous thrombosis in children can be also caused by congenital factors associated with coagulation disorders. The paper describes a case of a 3-month-old girl who developed isolated splenic vein thrombosis after a fall from height. Laboratory and genetic findings excluded thrombophilia. A 3-month anticoagulant treatment was administered. Gradual reduction in splenic size and the development of collateral circulation were observed in subsequent ultrasound scans. The girl remains under the care of a surgical clinic. The presented case of an infant with splenic vein thrombosis draws attention to possible complications of abdominal trauma after a fall from height.
Infantile parotid haemangioma: a report of three cases
Authors:   Department of Otorhinolaryngology, Hospital Tuanku Ja’afar, Jalan Rasah, 70300 Seremban, Negeri Sembilan, Malaysia, Mohd Ariffin Nur Izzaty Nadia , Saniasiaya Jeyasakthy ,   Department of Otorhinolaryngology, Faculty of Medicine, University of Malaya, Jalan Universiti, 50603 Kuala Lumpur, Malaysia, Moses Shamina Sara ,   Department of Otorhinolaryngology, Hospital Umum Sarawak, Jalan Hospital, 93586 Kuching, Sarawak. Malaysia, Gani Norhaslinda Abdul ,   Department of Otorhinolaryngology, Hospital Tuanku Ja’afar, Jalan Rasah, 70300 Seremban, Negeri Sembilan, Malaysia
Published: October 2021

Aim of this case: To highlight the presentation of rapidly enlarging parotid haemangioma in three children who were all successfully managed with oral propranolol. Case report: Parotid haemangioma in infancy, albeit rare, has been vastly reported due to it being the most common tumour of the salivary gland in infants. Despite that, the presence of a rapidly enlarging tumour in “the little ones” may be daunting, leading to countless unwarranted procedures by attending physicians. Herein, we present three cases of infantile rapidly tumefying parotid lesions which were diagnosed clinically with the support of imaging, and successfully managed by promptly initiating oral propranolol. Conclusion: Although several recent reports have been reviewed, the challenges in diagnosis and management of the condition need to be individualised.
Protein characterisation and antioxidant potential of fresh cheese obtained by kombucha inoculum
Authors:   University of Novi Sad, Faculty of Technology Novi Sad, Bulevar Cara Lazara 1, 21000 Novi Sad, Serbia, Bjekić Maja
Published: October 2021

Protein profile, in vitro gastrointestinal digestion and antioxidant potential of two fresh cheese samples obtained by kombucha inoculum and traditional starter culture have been investigated in this study. There is a significant difference in protein profile and bioactive potential between fresh cheese samples. Kombucha fresh cheese contains higher proportion of protein, predominantly the casein fractions (α-casein and β-casein) compared to fresh cheese obtained by traditional culture. After gastrointestinal digestion (with pepsin and pancreatin), significantly higher amount of soluble protein and higher degree of hydrolyses were measured in kombucha fresh cheese sample than sample obtained by traditional culture. During gastrointestinal digestion, for fresh cheese with traditional starter both fractions of casein are degraded more rapidly by pepsin than in kombucha fresh cheese. The hydrolysates of cheese obtained by kombucha inoculum showed higher phenolic content and higher antiradical scavenging abilities than hydrolysates of fresh cheese produced with traditional starter. These results suggest that kombucha inoculum contributes to improvement of product’s bioactive potential.
Evaluation of microbial quality and safety of selected dairy products with special focus on toxigenic genes of Bacillus cereus
Authors:   Cairo University, Faculty of Veterinary Medicine, Department of Food Hygiene and Control, Giza, Egypt, Salwa Adam A.H.
Published: October 2021

Although dairy products play a significant role in human nutrition, they may cause a risk to the consumers. This study intends to determine the microbial contamination level in selected milk products concerning Bacillus cereus enterotoxigenic genes. Three hundred plant-origin flavoured cheese, flavoured yogurt, flavoured drinking yogurt, kareish (skim milk cheese), soft cheese, and Ras (Romy) cheese (50 samples for each) were randomly collected from retail markets at different districts in El Fayoum Governorate, Egypt. The microbiological analysis and the molecular identification of Bacillus cereus by multiplex PCR were applied and revealed potential risks associated with consumption of the tested milk products (white soft, Ras, and kareish cheeses). In all analysed cheeses (white soft, Ras and kareish) a high contamination level with coagulase positive staphylococci (20.0%, 22.0% and 20.0%) and coliform bacteria (76.0, 86.0, and 88.0%) was detected. The highest percent (78.0%) of fungi was found in kareish cheese samples. Bacillus licheniformis was the most aerobic spore forming bacteria detected in kareish cheese (23.7%) and flavoured drinking yogurt (17.0%) samples. The highest prevalence (8.0%) of Bacillus cereus was recorded in the flavoured drinking yogurt and white soft cheese samples. The (nhe) was the most detected gene (100.0%) in all of the examined samples. There was a significant difference (p<0.05) between nhe and ces genes in all investigated samples except in flavoured drinking yogurt samples. Salmonella sp., Escherichia coli and Pseudomonas aeruginosa were not detected. This survey is one of the very few surveys that describe the safety and quality status of plant-origin flavoured cheeses and flavoured drinking yogurt, particularly in Egypt.
A Neglected Case of Wilson’s Disease Presenting as Symptomatic Urolithiasis and Proteinuria
Authors: Zare Elham , Mahbubi Zahra , Panahi Maryam
Published: October 2021

We report a short-statured, 39-year-old male presenting with recurrent kidney stones, history of refractory rickets, and bone deformity. He had been consuming multiple doses of calcium supplements and multiple courses of vitamin D over past 30 years beforeprior to reporting in our clinic without any significant laboratory or clinical improvement. The patient was diagnosed as having Fanconi’s syndrome attributable to Wilson’s disease. This patient highlighted that in case of resistant rickets, a high index of uncertainty must be invoked for Wilson’s disease. Appropriate timely recognition of this entity results in prompt ministrations and prevention of disability. We also presented and discussed reviews on Wilson’s disease from literature.
FUZZY RELATIONAL DATABASE MODEL AND MANAGEMANT SYSTEM FOR IMPRECISE INFORMATION
Authors: Nguyen Hoa , Nhi Nguyen Thi Uyen , Duy Le Nhat
Published: October 2021

This paper introduces a fuzzy relational database model (FRDB) and the management system for it. FRDB is built by extending the classical relational database model with the fuzzy membership degree of tuples in relations. The management system for FRDB with the querying language like SQL is built by using a classical open-source management system.
A HYBRID MODEL USING THE PRETRAINED BERT AND DEEP NEURAL NETWORKS WITH RICH FEATURE FOR EXTRACTIVE TEXT SUMMARIZATION
Authors: Luu Tuan Minh , Le Huong Thanh , Hoang Tan Minh
Published: October 2021

Deep neural networks have been applied successfully to extractive text summarization tasks with the accompany of large training datasets. However, when the training dataset is not large enough, these models reveal certain limitations that affect the quality of the system’s summary. In this paper, we propose an extractive summarization system basing on a Convolutional Neural Network and a Fully Connected network for sentence selection. The pretrained BERT multilingual model is used to generate embeddings vectors from the input text. These vectors are combined with TF-IDF values to produce the input of the text summarization system. Redundant sentences from the output summary are eliminated by the Maximal Marginal Relevance method. Our system is evaluated with both English and Vietnamese languages using CNN and Baomoi datasets, respectively. Experimental results show that our system achieves better results comparing to existing works using the same dataset. It confirms that our approach can be effectively applied to summarize both English and Vietnamese languages.
COMPUTATION COMPLEXITY OF DEEP RELU NEURAL NETWORKS IN HIGH-DIMENSIONAL APPROXIMATION
Authors: Dũng Dinh , Nguyen Van Kien , Thao Mai Xuan
Published: October 2021

The purpose of the present paper is to study the computation complexity of deep ReLU neural networks to approximate functions in H\"older-Nikol'skii spaces of mixed smoothness $H_\infty^\alpha(\mathbb{I}^d)$ on the unit cube $\mathbb{I}^d:=[0,1]^d$. In this context, for any function $f\in H_\infty^\alpha(\mathbb{I}^d)$, we explicitly construct nonadaptive and adaptive deep ReLU neural networks having an output that approximates $f$ with a prescribed accuracy $\varepsilon$, and prove dimension-dependent bounds for the computation complexity of this approximation, characterized by the size and the depth of this deep ReLU neural network, explicitly in $d$ and $\varepsilon$. Our results show the advantage of the adaptive method of approximation by deep ReLU neural networks over nonadaptive one.
Construção de um kit experimental com arduino para ensino de oscilações em tempo real
Authors: Matos Pereira Pedro Davi , da Silva Marcelo Souza
Published: October 2021

O estudo das oscilações pode se configurar como uma rica oportunidade para o desenvolvimento de atividades experimentais. Entretanto, devido a uma série de dificuldades instrumentais, muitos professores optam por trabalhar apenas com um cronometro para obtenção da frequência média das oscilações. A aquisição dos dados de posição em função do tempo está disponível, em geral, para quem tem acesso a kits experimentais caros. Neste artigo propomos a construção e utilização de um kit experimental para estudo de oscilações utilizando arduino. Por meio de um sensor ultrassônico HC-SR04, pode-se construir gráficos de posição (velocidade e aceleração) em tempo real, permitindo a visualização do comportamento senoidal apresentado pela teoria, e possibilitando maior compreensão do fenômeno além da determinação de grandezas físicas envolvidas. O kit inclui um software desenvolvido em C + + , denominado PMOscillator, responsável pela aquisição, processamento, plotagem em tempo real e análise dos dados.
Video analysis using a shaking camera
Authors: de Jesus V. L. B. , Sasaki D. G. G.
Published: October 2021

To perform a reliable video analysis, it is mandatory to avoid shaking the camera while taking the video, normally using a tripod for smartphones/cameras. But there are some situations which the only chance to make the video is using your hands and it is almost impossible to avoid shaking the camera even trying your best. Imagine the following situation: a volleyball is obliquely launched, and the video is filmed by hand. Then, a point that is fixed in relation to the ground is chosen as the origin of a ground fixed reference frame. Despite being a ground fixed point, it will appear shaky in images captured by the handheld camera. Thereby, two standard video analyses are performed, one from the ground fixed point random shaking and one from the ball’s trajectory, both in relation to the default reference frame of the video analysis software. Lastly, to implement the video analysis of the relative ball movement it is enough to subtract the position coordinates of the ball’s movement by the position coordinates of the ground fixed point tremble, at each instant of time. The graphs of the position and velocity components versus time are presented, and the results are discussed.
A framework for assessment of flood vulnerabilities – case of Narmada River Basin, India
Authors: Pathak Shefali Dubey , Kulshrestha Mukul
Published: October 2021

The aim of this study is to lay a framework for evaluating flood vulnerabilities. Specifically, it applies the proposed methodology to evaluate flood vulnerability index (FVI) across 21 districts comprising a significantly large part (drainage area of 85 859 km2) of Narmada River basin in the central Indian state of Madhya Pradesh. The study assesses sensitivity, adaptive capacity indices, and the exposure risk over a chosen set of 22 climatic, demographic, social and economic parameters, and applies principal component analysis to evolve a composite FVI. The results rank various districts for their vulnerabilities to floods. The analysis indicates that, in the study area, around a third of the vulnerability is accounted by two factors: a lack of adaptive capacity of the community and heightened sensitivity to floods. There exists significant scope to modify these two factors by appropriate policy interventions at the social and economic levels. It is expected that the framework would be of use to stakeholders such as planners, policymakers, flood management authorities, field engineers, district administration and local non-governmental organisations who strive to make the community less vulnerable to floods.
Construcción de normas: una experiencia desde el clima de aula
Authors: Rodríguez Buitrago Anderson Geovany
Published: October 2021

Objetivo: Este documento presenta algunos análisis sobre la percepción que tienen los estudiantes respecto a la construcción de normas dentro del clima de aula. Metodología: Se analizaron datos derivados del macroproyecto “Instituciones Educativas Vivas”, a través de encuestas realizadas a estudiantes de la Institución Educativa Técnica Internado San Francisco de Loretoyaco de Puerto Nariño (Amazonas). La investigación se llevó a cabo bajo la metodología de tipo no experimental, descriptiva. Resultados: Se pudo constatar la importancia de generar una cultura de participación. Conclusión: Entre las principales conclusiones se pudo evidenciar la importancia del docente en la construcción participativa de normas.
Promoción del desarrollo como práctica de crianza de las madres adolescentes
Authors: Henao García Nadia Milena , Villa Gil Mónica María
Published: October 2021

Objetivo. Mostrar los resultados de la investigación “Prácticas de crianza en madres adolescentes” en la categoría Desarrollo. Caracterizar las prácticas de crianza que promueven el desarrollo infantil, y que a su vez propician bienestar y satisfacción con la vida. Metodología. El diseño metodológico es holístico-descriptivo. Resultados. Se encontraron tres subcategorías: la cognitiva, en la cual las madres reconocen la implementación de juegos y ejercicios matemáticos; la corporal, ya que promueven la estimulación física y la participación en los programas de control y desarrollo, y la estética, ya que propician espacios al niño para que valore sus formas de sentir e interactuar. Conclusión. La mujer en su rol de madre es la que facilita el desarrollo de los niños; sin embargo, es una tarea que la sociedad le atribuye en medio de un contexto que cada vez le asigna más tareas en la crianza, pero que la deja más sola para asumirlas.
Movimientos sociales y el derecho internacional: avances y retos
Authors: Burgos Silva José Germán , Sánchez Vargas Juan David
Published: October 2021

Objetivo. El siguiente escrito se propone reunir un conjunto de entradas teóricas del derecho internacional alternativas a las entradas dominantes centradas en la participación de los Estados y organizaciones internacionales en la construcción de normas internacionales. Metodología. Con base en el análisis documental se examina la clave en que se ha desarrollado la relación entre el derecho internacional y los movimientos sociales. Resultado. Como resultado se obtuvo un marco general para entender en qué términos se ha explorado dicha relación. Conclusión. Se concluye con los avances que se han gestado en esta relación, y con los retos mayores para la academia con miras a la construcción de un marco teórico del derecho internacional de los movimientos sociales.
Dictionnaire ouvert et traducteur automatique au service de l’enseignement/apprentissage du lexique
Authors: YUN-ROGER Soyoung
Published: October 2021

Cet article présente un dispositif d’enseignement du lexique académique coréen qui aide les étudiants à surmonter les difficultés d’apprentissage de ce lexique constitué de nombreuses unités phraséologiques impliquant des relations collocationnelles. L’enseignement proposé s’appuie sur une composante technologique, l’utilisation d’outils numériques en ligne comme les traducteurs automatiques et un dictionnaire ouvert, et sur une composante actionnelle, les étudiants devant contribuer, via une séquence de tâches, à enrichir un dictionnaire ouvert. Nous avons observé que ce dispositif stimule et responsabilise les étudiants dans leur apprentissage, et que la séquence de tâches, en multipliant les manipulations du lexique, en favorise l’appropriation. Enfin et surtout, ces tâches ont conduit les apprenants à diversifier leurs stratégies d’apprentissage du lexique, et leurs stratégies de vérification de leurs productions.
Le glossaire de Moodle
Authors: OUVRARD ANDRIANTSOA Louise
Published: October 2021

Selon la définition que Py donne de la décontextualisation, celle-ci « consiste, pour l’apprenant, à focaliser et extraire de son contexte le segment (le plus souvent un mot) qu’il souhaite apprendre. » (1996 : 16).

Au cours des différentes phases de l’apprentissage, cette opération est régulièrement effectuée en classe à l’initiative de l’enseignant. Elle peut aussi l’être à l’initiative de l’apprenant et certaines activités peuvent l’y inciter.
En présentiel ou en distanciel, les cours de langue sont amenés à utiliser des outils variés permettant un travail systématique sur la langue. Au nombre de ceux-ci figure le glossaire. Nous avons intégré cet outil proposé par Moodle dans nos cours de grammaire malgache des trois niveaux de la licence. Pour répondre au mieux aux objectifs que l’enseignant a établis, ce glossaire est paramétrable selon différents critères qui concernent par exemple l’affichage des articles (avec ou sans auteur), l’approbation (automatique ou non). Il peut également être construit par l’enseignant ou par les étudiants eux-mêmes.
C’est donc notre démarche que nous présentons dans cet article, le travail effectué par nos étudiants, les postulats de départ et les contraintes liées à ce type d’outils
Nous concluons sur les apports que ce glossaire a représenté pour nos cours, aussi bien en termes de savoirs que de savoir-faire.
Efficacy of customized insoles in the improvement of plantar pressure in patients with diabetic neuropathy: Protocol of a randomized and controlled clinical trial
Authors: Farhat Gabriel , Martins Camila Marinelli , Gomes Ricardo Zanetti , Galvão Letícia Carollyne , Kravutschke Rodolfo Martins , Teixeira Alves Fabiana Bucholdz
Published: October 2021

OBJECTIVE: To evaluate the influence of customized insoles in the plantar pressure of diabetes patients with neuropathy in comparison to the sham group. METHODS:  The work method, duly registered at the Registro Brasileiro de Ensaios Clínicos – REBEC (Clinical Trial Brazilian Register) (http://www.ensaiosclinicos.gov.br/) RBR-5NQK4K, includes a randomized, controlled, prospective, double-blinded clinical trial, with a sample of 46 volunteers that will be randomly randomized in a 1: 1 ratio to be referred to intervention and control groups. The intervention group will receive customized insoles, with a retrocapital bar and an ethyl vinyl acetate plaque (EVA) in the same shape as the retrocapital bar, in order to reduce the pressure on the forefoot. In the control group, flat insoles will be prepared without any therapeutic objective. This project was developed according to the standard protocol for randomized clinical trials (SPIRIT). Along with the clinical evaluation, demographic data of the sample will be collected to identify and confirm the presence of peripheral neuropathy, next, the pedobarographic will be evaluated, and finally, the patients will answer the FAAM questionnaire to assess foot functionality. The primary outcome will be analyzing pressure points in KiloPascal (kPa) in the patients’ feet through pedobarographic of the patients in the intervention and control groups. The secondary outcome will be the foot functionality in activities of daily living through the FAAM (Foot and Ankle Ability Measure), considering the volunteers in the initial evaluation, third and sixth months.  FINAL CONSIDERATIONS: Mainly, results of this study will show whether there is a structural alteration in the analysis of the plantar pressure due to the continuous use of insoles and present the evaluation of whether the use of therapeutic insoles improves the foot functionality of the same users when compared to sham insoles.
Efficacy of acupuncture in the management of fatigue related to breast cancer antineoplastic treatment: a systematic review
Authors: Costa Ana Carolina Moraes , Medrado Alena Peixoto
Published: October 2021

INTRODUCTION: Breast cancer is the most prevalent cancer among women worldwide. Similar to chemotherapy, antineoplastic treatment is associated with many side effects, with fatigue being one of the most common. It is important to investigate potential treatments, especially non-pharmacological alternatives, to control symptoms that directly affect women’s quality of life. OBJECTIVE: The objective of this study was to provide scientific evidence to verify the efficacy of acupuncture in the management of fatigue in patients with breast cancer. METHODS: This study involved a systematic review based on the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) methodology. Randomized clinical trials published in indexed scientific journals were compiled. The literature search was performed using the electronic databases, PubMed, PEDro, and BIREME, using the descriptors ‘breast cancer’, ‘fatigue’, ‘acupuncture’, and ‘randomized trial’. Inclusion criteria included fully available online articles that were classified as randomised clinical trials published from 2012 to 2017 in either English or Portuguese. Study eligibility was based on the Population, Intervention, Control, Outcome, and Study (PICO) design criteria, in which the (1) population included women 18–65 years of age with breast cancer, (2) intervention was acupuncture, (3) comparison referred to standard care or sham acupuncture, and (4) outcome was the evaluation of fatigue. The PEDro scale was applied to evaluate the quality of the studies. WebQualis was also used to evaluate the quality of the journals of the selected articles. RESULTS: In total, 66 articles were selected, but only four fulfilled all inclusion criteria, giving a total sample size of 620 women. All trials evaluated the effect of acupuncture on fatigue and other symptoms related to the treatment of breast cancer with different treatment durations. Three articles reported statistically significant results, and all articles described clinical improvement in fatigue after the application of acupuncture. The average PEDro score of the manuscripts was 6.25. All articles were published in non-Brazilian journals with WebQualis scores that ranged from B2 to A1. CONCLUSION: Scientific evidence confirms the efficacy of acupuncture in the management of fatigue reported by women with breast cancer. Acupuncture was effective in reducing fatigue in the studies selected for this review.
Participação paterna na unidade de terapia intensiva neonatal segundo a concepção da equipe de enfermagem
Authors: Afonso Gustavo Assis , Xavier Francisco Nycolas Ferreira , Carvalho de Castro Rosane Belo
Published: October 2021

OBJETIVO: identificar a visão de membros da equipe de enfermagem acerca da participação do pai durante a hospitalização do recém-nascido na unidade de terapia intensiva neonatal. MÉTODO: abordagem exploratória de natureza qualitativa, por intermédio de um questionário aberto, e posteriormente, submetido à análise de conteúdo de Bardin. RESULTADOS: o exame das entrevistas levou à construção de três categorias: discrepância em reconhecer a singularidade do pai no trinômio pai-mãe-filho; o acolhimento e a inserção do pai no contexto de cuidados com o RN; criação do vínculo familiar e auxílio no desenvolvimento clínico do RN. CONCLUSÃO: A equipe de enfermagem reconhece a figura paterna como provedor de benefícios para o RN e implementa práticas que promovem o seu acolhimento e aproximação com o filho. Contudo, equipe ainda possui uma visão defasada sobre a verdadeira função da paternidade no contexto familiar, contribuindo para a criação de um estigma social do homem como coadjuvante.
Sífilis em gestantes no Acre: uma análise do período compreendido entre 2015 a 2020
Authors: Da Costa Ruth Silva lima , Silva Cavalcante Gerlane , De Paula Maria Dulcilene do Nascimento Araujo , Nascimento Natiele Silva , Conceição Matilde da Silva , Souza Christopher Wando da Silva
Published: October 2021

OBJETIVO: Descrever os casos de sífilis em gestantes no estado do Acre no período compreendido entre 2015 a 2020. MÉTODO: Estudo ecológico descritivo com a utilização de dados secundários disponíveis no site do Departamento de Informações do Sistema Único de Saúde – DATASUS, tabulados a partir do TABNET. As variáveis utilizadas foram: ano de notificação, grau de instrução, faixa etária, raça/cor, classificação clínica, idade gestacional e esquema de tratamento. RESULTADOS: Foram notificados 2443 casos no período. A maioria encontrava-se na faixa etária entre 20 a 29 anos, 1146 (47%), com ensino fundamental incompleto, 677 (28%), e raça/cor parda, 1983 (81%). A doença apresentou seu pico mais elevado no ano de 2018, com a notificação de 627 (26%) casos, e uma redução partir deste ano. A maior parte foi classificada como sífilis primária 900 (37%), diagnosticadas no 1º trimestre da gravidez 876 (36%). Quanto ao esquema de tratamento, 1891 (77,4%) estavam sem informação no sistema, e a penicilina foi o antibiótico de escolha de 529 (21,7%). CONCLUSÃO: Os casos de sífilis no Acre apresentaram redução no último ano analisado, o que pode estar relacionado a baixa frequência ao pré-natal, em decorrência da pandemia de Covid-19. Foram acometidas mulheres jovens e classificadas com sífilis primária no 1º trimestre da gravidez.
Violência contra a pessoa idosa na região Nordeste do Brasil no período de 2012 a 2018
Authors: De Souza Lima Isabel Vitor , Palmeira Cátia Suely , De Macedo Tássia Teles Santana
Published: October 2021

OBJETIVO: Descrever a violência contra a pessoa idosa na região Nordeste do Brasil no período de 2012 a 2018. METODOLOGIA: Estudo descritivo ecológico de série temporal utilizando dados secundários do Sistema de Informação de Agravos de Notificação - SINAN no período de 2012 a 2018, disponíveis no site DATASUS. A população foi constituída por idosos na faixa etária de 60 anos e mais. Elegeram-se as variáveis: região de ocorrência, ano de notificação, sexo, raça/cor, escolaridade, local de ocorrência, tipo de violência e característica do agressor. RESULTADOS: No período foram registrados 18.357 casos de violência contra o idoso, ocorrendo aumento, com maior proporção no estado de Pernambuco (6668; 36,3%), com predominância no sexo feminino (9393; 51,2%), pardos (11.250; 61,3%) e ? 3 anos de estudo (4.238; 60,5%). Observa-se que a violência acontece predominantemente na própria residência dos idosos (11.174; 60,9%), sendo a violência física a mais frequente (28,0%), seguida por negligência/abandono (17,3%). Maior número de registro de casos de violência foi cometido pelos filhos (5578; 43%) CONCLUSÃO: O registro de casos de violência contra os idosos aumenta a cada ano na região Nordeste, sendo as mulheres com baixa escolaridade as mais acometidas. Os dados apresentados apontam à necessidade de intervenções especificas de prevenção e controle da violência contra o idoso.
Itinerários terapêuticos realizados por gestantes adeptas de religiões afro-brasileiras
Authors: Mouta Ricardo José Oliveira , Borges Elizabeth Sabino dos Anjos , Prata Juliana Amaral , Teixeira Aldira Samantha Garrido , Freire Renata Pascoal , Lopes Fernanda Maria do Vale Martins
Published: October 2021

OBJETIVO: Conhecer os itinerários terapêuticos realizados por gestantes adeptas de religiões afro-brasileiras no Rio de Janeiro. METODOLOGIA: Estudo exploratório, descritivo e qualitativo, com 20 puérperas. Os dados foram coletados no período de julho a setembro de 2018, por meio de entrevistas, e submetidos à análise de conteúdo. RESULTADOS: As influências das religiões afro-brasileiras durante o período gravídico revelaram ações de cuidado que perpassam por acolher, apoiar, revigorar, tranquilizar-se e aceitar. Sobre os itinerários terapêuticos das participantes, constatou-se: consultares oraculares; rituais envolvendo orixás e guias espirituais; e práticas específicas para o parto. Ainda, as gestantes adeptas das religiões afro-brasileiras relataram situações de intolerância religiosa vivenciadas no ambiente familiar e no espaço do cuidado. CONCLUSÃO: As gestantes de religião afro-brasileira construíram itinerários terapêuticos no qual também mantinham vinculo com o serviço de pré-natal, assim como eram acolhidas nos terreiros. As práticas religiosas atuaram como alternativa e/ ou complementariedade terapêutica no processo assistencial da gestação.
Percepção dos pais sobre técnicas de controle comportamental na Clínica Odontopediátrica da Faculdade UniRuy, Salvador-BA
Authors: Brito Gabriela Xavante de Oliveira Santana , Machado Cíntia de Vasconcellos
Published: October 2021

OBJETIVO: Avaliar a percepção dos pais e/ou responsáveis das crianças atendidas na clínica odontopediátrica da Faculdade UniRuy, sobre as técnicas de manejo comportamental que podem ser utilizadas durante o atendimento infantil. METODOLOGIA: Para a realização da pesquisa, os pais e/ou responsáveis responderam a um questionário, onde havia uma breve explicação sobre determinadas técnicas de manejo do comportamento infantil, assim como se concordavam ou não com o uso das mesmas. Estavam presentes nos questionários as seguintes técnicas: falar-mostrar-fazer, comunicação não verbal, controle de voz, reforço positivo, distração, modelagem ou imitação, estabilização protetora e mão-sobre-a-boca. Todos os participantes do estudo responderam ao Termo de Consentimento Livre e Esclarecido. RESULTADOS: Foram respondidos 53 questionários, onde a técnica de controle do comportamento com maior aceitação pelos pais foi a de “falar-mostrar-fazer” (100%) e a com maior rejeição foi a “mão-sobre-a-boca” (75%), evidenciando uma maior rejeição por técnicas que restringem os movimentos da criança. CONCLUSÕES: As técnicas de controle comportamental visam reduzir a ansiedade e o medo da criança no ambiente odontológico, modulando o seu comportamento, afim de permitirem um atendimento seguro para o paciente, tanto do ponto de vista físico como emocional. Toda a equipe profissional deve ter o conhecimento e domínio de tais técnicas, assim como uma compreensão sobre os aspectos psicológicos das crianças em cada etapa do seu desenvolvimento. Da mesma forma, é crucial o entendimento e a permissão dos pais para a realização de técnicas que limitem os movimentos das crianças, como a estabilização protetora.
Pubmed search for case control and emergency v1
Authors: Saadat Soheil
Published: October 2021

Pubmed search for (emergency) AND (case control)
Application of OLAP Technology in the Environment of Electronic Demography
Authors:   Institute of Information Technology of Azerbaijan National Academy of Sciences, Baku, Azerbaijan, Nabibayova G. Ch.
Published: October 2021

The article proposes an approach to the development of an electronic demographic decision support system using technologies of Data Warehouse (DW) and Interactive Analytical Processing OLAP. This makes it possible to conduct high-level demographic research and provide support to decision-makers in demographic sphere. The article notes that demography is an interdisciplinary field of research and is defined as a complex science. Each industry of demography has many indicators. A sample list of these indicators is presented. The main characteristics of the DW, which should be taken into account when developing its architecture, are stated. Among these characteristics, one can find the main defining characteristics of Big Data — volume, velocity, variety, veracity, variability, visualization, value etc. For a more rational and efficient use of a large amount of information, taking into account its constant increase, to ensure the speed of execution of requests for a given system, it is proposed to use a Bus of Interconnected Data Marts (DM) as an architecture of DW. One of the advantages of using DM is that their use assumes distributed parallel data processing. This architecture allows for much faster results generation. It is based on the MapReduce distributed computing model and the Hadoop project. In addition, to effectively use large amounts of data, it is also proposed to use OLAP operations such as roll-up and drill-down, as well as fuzzy set theory, based on the technique of computing with words. The article also shows the practical application of interconnected DM. An OLAP cube is built on the basis of these DM. OLAP operations provide the ability to view cubes in different slices and provide aggregate data.
RELATIONSHIP OF LYMPHOCYTE SUBPOPULATIONS IN BREAST CANCER PATIENTS WITH TREATMENT RESULTS
Authors: Zabotina T. N. , Chertkova A. I. , Borunova A. A. , Zakharova E. N. , Shoua E. K. , Artamonova E. V. , Kovalenko E. I. , Horoshilov M. V. , Kadagidze A. G.
Published: October 2021

Introduction. Breast cancer (BC) is an immunogenic tumor. Immune cells infiltration of tumor tissue can affect the clinical course of the disease. The immunogenicity of breast cancer varies depending on the molecular subtype.

The aim of this work was to study the main indicators of systemic and local immunity before patient’s treatment and to determine their relationship with the immediate neoadjuvant chemotherapy results.

Materials and methods. Patients with stage II–III BC received standard neoadjuvant chemotherapy in accordance with the molecular subtypes. The percentage of the main effector and regulatory lymphocytes populations of systemic and local immunity was determined by flow cytometry.

Results. A decrease in the level of effector CD8 and CD4 lymphocyte populations and an increase in the level suppressor populations in tumor tissue in comparison with peripheral blood indicate an immunosuppressive state of local immunity in BC patients. In tumor tissue, a high level of CD8+ PD-1+ and CD4+ PD-1+ cells were associated with a high level of regulatory CD4+ CD25highCD127–/low and CD8+ CD11b– CD28– lymphocytes. Differences were found in the significance of individual lymphocyte populations for the immediate results of treatment between patients with different subtypes of breast cancer.

Conclusion. Determination of lymphocyte subpopulations correlating with the level of PD-1 cells, and the results of treatment in patients with different molecular BC subtypes, will help a clearer understanding of the antitumor immune response in this pathology, and will also serve as a basis for identifying immune biomarkers that can be used as additional predictive factors in various treatment options for BC patients.
EFFECTS OF 5-HYDROXYPYRIMIDINE DERIVATIVE ON GROWTH AND METASTASIS OF MELANOMA B16 IN C57BL/6 MICE
Authors: Zhurikov R. V. , Kovalenko L. P. , Nikitin S. V. , Durnev A. D.
Published: October 2021

Introduction. Suppression of activation of an alternative immune response is promising approach of tumor immunotherapy. In this study we evaluated antitumor and antimetastatic activity of SNK-411.

Objective. Evaluation of antitumor and antimetastatic activity of 5-hydroxypyrimidine derivative SNK-411 in mouse melanoma B16 model.

Materials and methods. Antitumor and antimetastatic activity of the SNK-411 were studied in tests on male C57BL/6 mice using the B16-F10 melanoma model. SNK-411 was injected intraperitoneally at doses of 10 and 25 mg/kg from day 2 to day 15 of melanoma development. Doxorubicin was injected at dose of 4 mg/kg on day 2 of tumor development to act as positive control. Antitumor and antimetastatic activity were studied by calculation of tumor growth inhibition and metastasis inhibition index (MII).

Results. SNK-411 at doses of 10 and 25 mg/kg and in combination with single injection of doxorubicin in dose of 4 mg/kg showed antimetastatic activity. MII in SNK-411 at 10 mg/kg dose was 72 %, at dose of 25 mg/kg was 82,9 %. The combination of 14-day course of intraperitoneal injections of SNK-411 at dose of 10 mg/kg and injection of doxorubicin 4 mg/kg revealed MII 97,1 %, in half of mice in this group metastasis were not observed on 21st day of melanoma development. All results are statistically significant. There was no significant inhibition of tumor growth in all groups.

Conclusion. SNK-411 has antimetastatic activity in tests on melanoma B16 model. Further investigation is required.
INSTITUTE OF PUBLIC SERVANTS RESPONSIBILITY IN THE SYSTEM OF SERVICE LAW OF UKRAINE
Authors: Berlach А.
Published: October 2021

The article is devoted to the research of the institute of responsibility of public servants in the system of service law of Ukraine. It is emphasized the importance of legal support for the functioning of the public service system, in particular the regulation of the mechanism of responsibility of public servants. It is noted that the institution of responsibility is a mandatory element of the system of every branch of law, including official, because it is this legal entity whose task is to ensure the proper implementation of the legal status of every public servant. Considering the responsibility of public servants from the standpoint of social and legal content, the author emphasizes that the views of scholars on this issue are very different, as they reflect the palette of the worldview of each individual researcher and characterize the various aspects of public relations. In a wide sense, responsibility is a legal relationship between public authorities in the person of its authorized bodies and subjects of law, for the accurate and conscientious implementation of the requirements contained in the relevant rules of law. Analyzing the scientific views of scholars on responsibility, it is emphasized that in general, the liability of public servants should be understood as a procedurally established application of coercive measures of coercive influence on a particular public person for committing an offense. It is stated that the content of the legal nature of the institute of disciplinary responsibility of public servants, in particular in the system of service law of Ukraine, which needs proper research, remains important and extremely necessary for law enforcement and human rights activities of authorized subjects. Based on the analysis of scientific achievements of local and foreign scholars on the legal system, it is emphasized that currently there are different approaches to understanding the systemic structure of legal branches, in particular some scholars remain on the views developed in our time, while others try to adapt European researchers-lawyers on the system of law on modern Ukrainian realities. As a result, the author emphasizes that we can now state that each branch of law, which we call general, special or special law, always contains a list of legal norms in the appropriate relationship and sequence and thus ensuring the ability of the subject of rule-making, law enforcement or human rights activities to achieve the desired result – to create or harmonize existing social relations, giving them the status of legal relations. Keywords: public service, service law, responsibility, legal system, general, special and special part, sanctions.
Modern achievements in pharmacotherapy of osteoarthritis based on endo- and phenotyping
Authors: Sarvilina I. V. , Shavlovskaya O. A. , Gromova O. A. , Naumov A. V. , Sharov M. N. , Prokofyeva Yu. S.
Published: October 2021

The review of medical literature is devoted to modern data in the field of diagnosis and treatment of osteoarthritis using endo- and phenotyping. It includes the latest data on the epidemiology of osteoarthritis of different localizations, modern definitions and classifications of osteoarthritis endotypes and phenotypes, pathobiochemical patterns and pathomorphological parallels of disease phenotypes, new methodological approaches to the phenotyping of osteoarthritis (prognostic, prescriptive phenotyping, alternative methods), as well as modern advances in pharmacotherapy of the disease based on data from selected randomized controlled trials and meta-analyzes.
The Peculiarities of Parent-Child Relationship among Teenagers who are Addicted to Online Games
Authors: Eliseeva M.I. , Krieger E.E.
Published: October 2021

The family is one of the main institutions for raising a child, starting from the moment of birth and ending with his formation of a mature personality. The development of parent-child relations will determine the further formation of a person, including the emergence of addictions and other deviations. This article is devoted to the problem of the relationship between parents among teenagers who are addicted to online games. The sample consisted of 50 people, including students of secondary schools, public colleges and technical schools. Among them there are 21 girls and 29 boys aged 14 to 18 years. In the course of the study, test methods: PVP Questionnaire (Problem Video Game Playing Questionnaire) of Dr. Ricardo Tejeiro-Salguero and Dr. Rosa María Bersabé-Moran (designed to measure the disorder commonly referred to as video game addiction); questionnaire PCI (parent-child interaction) of I.M. Markovskaya. In the course of the study, a relationship was established between the assessment of satisfaction with relationships with parents and with the degree of dependence on video games in complete and single-parent families. The results showed that adolescents who are addicted to online games can experience disharmonious relationships with both their mother and father. It was found that the assessment of satisfaction with relations with parents does not depend on the composition of the family. The results also demonstrated the presence of violations in the structure of parent-child relations, which contribute to the escape from reality in online games in order to compensate for those needs that parents could not realize.
Silver nanoparticles: safety and efficiency for human health
Authors: Morozova Yuliya A. , Dergachev Dmitry S. , Subotyalov Mikhail A.
Published: October 2021

Over the past few decades, nanoparticles of metals, and in particular silver, with a diameter of less than 100 nm have significantly expanded their field of application for various biomedical purposes. So, silver nanoparticles have great potential in a wide range of applications as antimicrobial agents, coatings for biomedical products, carriers for drug delivery, bioengineering, since they have discrete physical properties and wide biochemical functionality. Studies have shown that the size, morphology, stability and properties (chemical and physical) of metal nanoparticles are strongly influenced by the conditions of the experiment, the kinetics of the interaction of metal ions with reducing agents and the adsorption processes of the stabilizer with metal nanoparticles. This review aims to analyze the use of silver nanoparticles in modern medicine based on data from domestic and foreign literature over the past five years. The study confirmed the high biological activity of drugs with nanoserebrum as anti-inflammatory, antimicrobial agents, antifungals, the presence of an inhibitory effect on protozoa, antioxidant and anticancer effects, and substantiated the relevance of use in bioengineering and dentistry. However, rapid advances and advances in technology have led to concerns about the potential risk associated with the use and application of silver nanoparticles to human health and the environment. Therefore, this review attempts to characterize and quantify the potential harmful effects of silver nanoparticles on the health of laboratory animals and humans, and focuses on ways to neutralize or reduce the toxic effects of silver nanoparticles on the human body.
Antioxidant and prooxidant systems in patients with ischemic insult
Authors: Belokoskova Svetlana G. , Tsikunov Sergey G.
Published: October 2021

The literature review presents current information on the role of oxidative stress in the pathogenesis of cerebral ischemia / reperfusion. In patients with ischemic stroke, activation of enzymatic and non-enzymatic links of antioxidant defense in the form of an increase in the blood and cerebrospinal fluid of the activity of superoxide dismutase, catalase, glutathione peroxidase and glutathione reductase, the content of glutathione reflects the presence of compensatory reserves, is a favorable factor for the restoration of brain functions. An increase in the content of markers of lipid peroxidation in various biological environments in patients with strokes, mainly malondialdehyde, even in combination with an increase in the content of markers of antioxidant protection, indicates its insufficiency and an unfavorable prognosis of the disease. An increase in the content of markers of lipid peroxidation, mainly malondialdehyde, in patients with strokes in various biological environments, even in combination with an increase content in markers of antioxidant protection, indicates its insufficiency, an unfavorable prognosis of the disease. The presence of affective disorders and the persistence of residual manifestations of ischemic stroke may be due to permanent oxidative stress. When choosing a therapy aimed at increasing the activity of antioxidant protection and reducing the toxic effect of prooxidants, one should take into account the severity and dynamics of metabolic disorders. In the presence of data reflecting insufficient activity of antioxidant systems in combination with increased activity of prooxidant systems, the appointment of drugs that reduce the severity of oxidative stress in the early stages of stroke is indicated. Therapy including antioxidant drugs is also indicated in patients with post-stroke affective disorders and with residual symptoms of stroke.