bluuebunny/crossref_metadata_2025 huggingface dataset:
Concurrent Diagnoses of Cutaneous Sarcoidosis and Recurrent Metastatic Breast Cancer: More than a Coincidental Occurrence?
Authors: Deen Jacqueline , Mellick Nick , Wheller Laura
Published: September 2018

Sarcoidosis is a rare, chronic, multisystem disease of unknown aetiology, characterised by non-caseating epithelioid cell granulomas. Its association with internal malignancy, in particular haematological cancers has been strongly documented in the literature, while its link with solid organ malignancies is less extensively reported. We present an atypical case of cutaneous sarcoidosis occurring in association with breast cancer recurrence in a 49-year-old female. Physician recognition of this link between sarcoidosis and internal malignancy is vital because many cases of sarcoidosis in association with neoplasia present initially, or even exclusively, with cutaneous sarcoidal lesions that may precede the development of cancer by several years, or as in our case, present as a cutaneous marker of concomitant underlying malignancy. Our case highlights the importance of age-appropriate cancer screening in additional to a routine work-up for systemic sarcoidosis in a patient with cutaneous sarcoidosis.
Sequencing Alpha-1 MZ Individuals Shows Frequent Biallelic Mutations
Authors: Foil Kimberly E. , Blanton M. Gwen , Sanders Chris , Kim Joannah , Al Ashry Haitham S. , Kumbhare Suchit , Strange Charlie
Published: September 2018

Rationale. Individuals with a single Z mutation in the SERPINA1 gene that codes for alpha-1 antitrypsin (AAT) are at increased risk for COPD if they have ever-smoked. Whether additional variants alter the risk for COPD in this population remains unknown. Objectives. To determine whether additional SERPINA1 variants impact COPD development in a previously identified MZ (carrier) cohort. Methods. Individuals with prior MZ results and AAT serum level <16uM were recruited from the Alpha-1 Coded Testing study and Alpha-1 Foundation Research Registry. Participants completed smoking history, demographics, and COPD Severity Score (Range 0-33) using REDCap data capture. At-home finger-stick tests were performed for next generation sequencing (NGS) at the Biocerna LLC laboratory. A genetic counselor reviewed records and interviewed participants with additional variants by NGS. A Wilcoxon Rank Sum test was used to assess correlation between variants and the COPD severity score. Results. A second SERPINA1 variant of known or possible significance was identified in 6 (5.8%) participants. One each of ZZ, SZ, FZ, ZSmunich, ZM2obernburg, and Z/c.922G>T genotypes were identified. ZZ, SZ, and FZ are known pathogenic genotypes. Smunich is a likely pathogenic variant. M2obernburg and c.922G>T are variants of uncertain significance. The ZZ individual was on augmentation therapy when determined MZ by protease inhibitor (Pi) phenotyping; the others had limited targeted genotyping with MZ results. These six participants with biallelic variants had positive COPD severity scores >1. Presence of additional variants was not significantly associated with COPD symptoms in this small sample size. Conclusions. Some diagnosed MZ individuals instead have biallelic variants. Larger studies are needed to determine COPD-risk liability of variants. Accurate diagnosis impacts medical management and familial risk assessment. Pi phenotyping can be confounded by augmentation therapy and liver transplantation. Because a normal M allele may be reported in the absence of tested mutation(s) in AATD genotyping, clinicians should consider clinical circumstances and laboratory methods when selecting and interpreting AATD tests. Advanced testing, including NGS, may be beneficial for select individuals with prior MZ results. Clinical Trial Registration. This study was registered with clinicaltrials.gov (NCT NCT02810327).
Dual Inhibition of DNA and Histone Methyltransferases Increases Viral Mimicry in Ovarian Cancer Cells
Authors: Liu Minmin , Thomas Stacey L. , DeWitt Ashley K. , Zhou Wanding , Madaj Zachary B. , Ohtani Hitoshi , Baylin Stephen B. , Liang Gangning , Jones Peter A.
Published: September 2018

Ovarian cancer ranks as the most deadly gynecologic cancer, and there is an urgent need to develop more effective therapies. Previous studies have shown that G9A, a histone methyltransferase that catalyzes mono- and dimethylation of histone H3 lysine9, is highly expressed in ovarian cancer tumors, and its overexpression is associated with poor prognosis. Here we report that pharmacologic inhibition of G9A in ovarian cancer cell lines with high levels of G9A expression induces synergistic antitumor effects when combined with the DNA methylation inhibitor (DNMTi) 5-aza-2′-deoxycytidine (5-aza-CdR). These antitumor effects included upregulation of endogenous retroviruses (ERV), activation of the viral defense response, and induction of cell death, which have been termed "viral mimicry" effects induced by DNMTi. G9Ai treatment further reduced H3K9me2 levels within the long terminal repeat regions of ERV, resulting in further increases of ERV expression and enhancing "viral mimicry" effects. In contrast, G9Ai and 5-aza-CdR were not synergistic in cell lines with low basal G9A levels. Taken together, our results suggest that the synergistic effects of combination treatment with DNMTi and G9Ai may serve as a novel therapeutic strategy for patients with ovarian cancer with high levels of G9A expression.

Significance: Dual inhibition of DNA methylation and histone H3 lysine 9 dimethylation by 5-aza-CdR and G9Ai results in synergistic upregulation of ERV and induces an antiviral response, serving as a basis for exploring this novel combination treatment in patients with ovarian cancer. Cancer Res; 78(20); 5754–66. ©2018 AACR.
A Novel MCL1 Inhibitor Combined with Venetoclax Rescues Venetoclax-Resistant Acute Myelogenous Leukemia
Authors: Ramsey Haley E. , Fischer Melissa A. , Lee Taekyu , Gorska Agnieszka E. , Arrate Maria Pia , Fuller Londa , Boyd Kelli L. , Strickland Stephen A. , Sensintaffar John , Hogdal Leah J. , Ayers Gregory D. , Olejniczak Edward T. , Fesik Stephen W. , Savona Michael R.
Published: September 2018

Suppression of apoptosis by expression of antiapoptotic BCL2 family members is a hallmark of acute myeloblastic leukemia (AML). Induced myeloid leukemia cell differentiation protein (MCL1), an antiapoptotic BCL2 family member, is commonly upregulated in AML cells and is often a primary mode of resistance to treatment with the BCL2 inhibitor venetoclax. Here, we describe VU661013, a novel, potent, selective MCL1 inhibitor that destabilizes BIM/MCL1 association, leads to apoptosis in AML, and is active in venetoclax-resistant cells and patient-derived xenografts. In addition, VU661013 was safely combined with venetoclax for synergy in murine models of AML. Importantly, BH3 profiling of patient samples and drug-sensitivity testing ex vivo accurately predicted cellular responses to selective inhibitors of MCL1 or BCL2 and showed benefit of the combination. Taken together, these data suggest a strategy of rationally using BCL2 and MCL1 inhibitors in sequence or in combination in AML clinical trials.

Significance:

Targeting antiapoptotic proteins in AML is a key therapeutic strategy, and MCL1 is a critical antiapoptotic oncoprotein. Armed with novel MCL1 inhibitors and the potent BCL2 inhibitor venetoclax, it may be possible to selectively induce apoptosis by combining or thoughtfully sequencing these inhibitors based on a rational evaluation of AML.

See related commentary by Leber et al., p. 1511.

This article is highlighted in the In This Issue feature, p. 1494
Epigenetic Age in Male Combat-Exposed War Veterans: Associations with Posttraumatic Stress Disorder Status
Authors: Verhoeven Josine E. , Yang Ruoting , Wolkowitz Owen M. , Bersani Francesco S. , Lindqvist Daniel , Mellon Synthia H. , Yehuda Rachel , Flory Janine D. , Lin Jue , Abu-Amara Duna  , Makotkine Iouri , Marmar Charles , Jett Marti , Hammamieh Rasha
Published: September 2018

DNA methylation patterns change with age and can be used to derive an estimate of “epigenetic age,” an indicator of biological age. Several studies have shown associations of posttraumatic stress disorder (PTSD) with worse somatic health and early mortality, raising the possibility of accelerated biological aging. This study examined associations between estimated epigenetic age and various variables in 160 male combat-exposed war veterans with (n = 79) and without PTSD (n = 81). DNA methylation was assessed in leukocyte genomic DNA using the Illumina 450K DNA methylation arrays. Epigenetic age was estimated using Horvath’s epigenetic clock algorithm and Δage (epigenetic age-chronological age) was calculated. In veterans with PTSD (Δage = 3.2), Δage was on average lower compared to those without PTSD (Δage = 5.0; p = 0.02; Cohen’s d = 0.42). This between-group difference was not explained by race/ethnicity, lifestyle factors or childhood trauma. Antidepressant use, however, explained part of the association. In the PTSD positive group, telomerase activity was negatively related to Δage (β = –0.35; p = 0.007). In conclusion, veterans with PTSD had significantly lower epigenetic age profiles than those without PTSD. Further, current antidepressant use and higher telomerase activity were related to relatively less epigenetic aging in veterans with PTSD, speculative of a mechanistic pathway that might attenuate biological aging-related processes in the context of PTSD.
DN4 QUESTIONNAIRE IN FAMILY PRACTICE FOR EVALUATION OF CLINICAL MANIFESTATIONS OF NEUROPATHIC PAIN IN TYPE 2 DIABETES PATIENTS TREATED BY LIGHT THERAPY
Authors: Makarchuk N. R.
Published: September 2018

Background. Peripheral diabetic polyneuropathy (DPN) is one of the most frequent neurological complications of diabetes mellitus (DM). Despite the large number of pharmacological agents, its treatment is not sufficiently effective, which necessitates the search for new therapies.Objective. The aim of the study was to increase the effectiveness of treatment of neuropathic pain in the patients with diabetic polyneuropathy by incorporating procedures using polarizing polychromatic non-coherent light (Bioptron light therapy) into the complex therapy of this disease.Methods. We examined 67 patients with type 2 diabetes complicated with diabetic polyneuropathy. Patients were divided into two groups: group 1 consisted of 32 patients, who received standard treatment; group 2 comprised 35 patients, who additionally underwent 12 light therapy treatments by means of the Bioptron Physiotherapy Unit. The evaluation of neuropathic pain intensity was performed using a modified questionnaire DN4. Results. A positive clinical effect of treatment was evidenced in both groups in 12 days of treatment. In 3 months, the intensity of complaints was significantly lower (p<0.05) only in the group with additional use of polarizing light. In 6 months, the positive effect of the therapy was leveled in the patients of both groups.Conclusions. The use of the DN4 questionnaire with a modified scale for assessing the parameters of neuropathic pain can optimize its diagnosis. The light therapy procedures together with the standard complex therapy of diabetic polyneuropathy increase the clinical efficacy of neuropathic pain treatment and help to preserve the therapeutic effect within 3 months.
Aspectos da gestão que influenciam o processo de planejamento municipal e regional do Sistema Único de Saúde
Authors: Vicentine Fernanda Bergamini , Delatorre Thatiane , Feltrin Aline Fiori dos Santos , Nakata Liliane Cristina , Soares Letícia , Ferreira Janise Braga Barros
Published: September 2018

Modelo do estudo: Estudo descritivo, transversal, com abordagem qualitativa. Objetivos do estudo: descrever e analisar a opinião de gestores e técnicos do setor saúde sobre os instrumentos e os recursos que integram o processo de planejamento no Sistema Único de Saúde. Metodologia: foram entrevistados 26 participantes, entre gestores e técnicos dos municípios e do estado que compõem o Departamento Regional Saúde XIII. Para análise dos dados, utilizou-se a Análise de Conteúdo em sua vertente temática. Resultados: o espaço de planejamento e cogestão regional, conhecido como Colegiado de Gestão Regional, se mostrou potente para a troca de experiências, mas apresentou fragilidades em relação a falta de coesão pelos diferentes níveis de conhecimento dos gestores e condições financeiras diversas entre os municípios. Notouse que a permanência dos gestores nos cargos foi positiva, desde que acompanhada por práticas de educação permanente. Por fim, a construção e a execução do planejamento tiveram como grandes barreiras o subfinanciamento e a judicialização na saúde, levando alguns municípios a escolha de políticas indutoras do nível federal e a terceirização da contratação de recursos humanos. Conclusão: O Colegiado de Gestores Regional apresentou grande potencial e poderia colaborar com a diminuição de retrocessos, a cada descontinuidade política, no processo de planejamento municipal e regional se fosse dado maior enfoque à coordenação federativa e ao aporte técnico do estado.
Escape distance and escape latency following simulated rapid bird attacks in an Andean lizard, Phymaturus williamsi
Authors: Fava Gustavo A. , Acosta Juan C.
Published: September 2018

Predatory birds represent the greatest risk for many lizard species. However, little is known about the functional relationship between the escape distance and escape latency of lizards during a rapid bird attack. We hypothesised that escape latency and distance in the Andean lizard speciesPhymaturus williamsiwould increase proportionally, but vary according to the means of escape. Over a three-year period we observed seven types of antipredatory behaviour in 98%P. williamsilizards on simulated predatory bird attacks. Escape distance and latency were positively correlated. 65% of lizards emerged from their refuge within 2 min of an attack. All of these behaviours were positively correlated with escape latency and distance, although we found the former to be more precise. This study contributes to a better understanding of the general antipredatory behaviour in this species of Andean lizard, and will assist in future decisions concerning its conservation.
First report of Branchinecta (Anostraca) in seasonal coastal pools in the Araucania region (Puaucho, 39°S, Chile)
Authors: De los Ríos Patricio , Carreño Eriko
Published: September 2018

To date, he fairy shrimps (Anostraca) of Chilean inland waters have been poorly described. Those that were described mainly belong to the genusBranchinecta, and the reports are primarily restricted to shallow seasonal pools at the northern and southern extremes of Chile. The aim of the present study was to give a first description ofBranchinecta rocaensis, reported from ephemeral coastal pools in the Puaucho dunes, situated in the Araucania region. The results of null model analysis revealed first, that species associations are random and that there is niche overlap, while according to the principal component analysis,B. rocaensiswas present at sites with low conductivity, low total dissolved solids and low temperature values, but with a high abundance of ostracods. The results obtained would agree with similar observations forBranchinectahabitats in southern Chilean Patagonia.
Fonctions de l’alternance entre arabe standard et vernaculaire libanais et connotations des deux codes dans un discours politique d’opposition
Authors: Germanos Marie-Aimée
Published: September 2018

Cet article s’intéresse aux fonctions de l’alternance entre arabe standard et vernaculaire ainsi qu’aux connotations des deux codes dans un discours prononcé par Hassan Nasrallah. Au regard des travaux antérieurs adoptant une approche fonctionnelle – comme c’est le cas ici – de l’alternance dans le discours politique arabophone, l’intérêt du texte analysé est double. Le premier aspect intéressant de la prise de parole concerne le positionnement, dans l’opposition, de l’orateur. Le deuxième a trait à la longueur de cette allocution, qui permet l’observation de schémas récurrents d’alternance. Il ressort de l’analyse dont les résultats sont présentés dans cet article que, dans le discours étudié, l’alternance est un procédé contrastif de mise en relief souvent utilisé en renforcement d’autres procédés rhétoriques ou stylistiques dont les fonctions sont proches. On aboutit en outre à la conclusion que les connotations de chacun des deux codes – le standard et le vernaculaire – se caractérisent par leur diversité, et que la réactivation, pour ce qui les concerne, d’une valeur spécifique, est propre à chaque énoncé.
A true long horn—a new species of Macronemus Dejean, 1835 (Coleoptera, Cerambycidae, Lamiinae, Acanthoderini) from the Bolivian Andes
Authors: PERGER ROBERT , SANTOS-SILVA ANTONIO
Published: September 2018

A new species of long-horned beetle, Macronemus waxrasapa sp. nov. from Bolivian Yungas forest, is described and illustrated.
Logging In to Press On: An Examination of High School Dropout and Completion Among Students With Disabilities in Online Courses
Authors: Sublett Cameron , Chang Yi-Chun
Published: September 2018

Students with disabilities (SWDs) continue to experience rates of high school dropout greater than students not receiving special education services. Furthermore, there is a persistent gap in the rates of high school completion among students with and without disabilities. While criticized for lowering standards and learning, online learning represents a plausible mechanism to both decrease dropout and increase high school completion among SWDs. Drawing on theoretical frameworks advanced by Dynarski et al. and Cavanaugh et al., the current study uses a nationally representative data panel to investigate the association between online coursetaking among SWDs and two dependent variables: high school dropout and completion. Results indicated that online coursetaking was associated with increased probabilities of high school completion among SWDs. Implications and policy recommendations are discussed.
Properties and Microstructure Study of Polyimide Foam Plastic
Authors: Zhang Y.Z. , Zhang G.C. , Sun X.F. , He Z. , Rajaratnam M.
Published: September 2018

Five kinds of polyimide (PI) foams were prepared from dianhydride and diamine by esterification process. The microstructure of foam was characterized by SEM and visualization methods, and many properties of material were measured, including heat resistance, fire resistance, compressive strength, heat insulation and acoustic absorption. It was shown that the cell size of foam was from 1 to 1.5 mm. The cell edge of PIBM and PIBO foam was obscure, and the cell wall was thinner than the PIBD, PIOD and PIBO-DM foam with thicker cell edge and poor cell size homogeneity. Five types of PI foams presented the trait of flexible foam plastics. All of them possess high decompose temperature, and their limiting oxygen index surpassed 40 percent, and thermal diffusion coefficients were less than 0.030 W/m·°C. In addition, PIBO, PIOD, and PIBO-DM foam had excellent acoustic absorption.
The Preparation and Performance of Phenolic Foams Modified by Active Polypropylene Glycol
Authors: Niu Ming , Wang Guojian
Published: September 2018

A series of active polypropylene glycols (APPGs) were synthesized by the reaction of hexamethylene-1,6-diisocyanate (HDI) and polypropylene glycol (PPG). They were then mixed and reacted with resol resin in catalyst condition to prepare the phenolic foams. The structure of modified phenolic foams was investigated. The influence of Mn of PPG and proportion of APPG on mechanical and fire-retardant performances of foams was discussed. The research results showed that the flexible PPG can be inducted into the crosslink structure of phenolic foam by the together crosslink reaction of –NCO groups in APPG with –CH2–OH groups in resol resin. When the molecular weight of PPG was 2000 and the dosage of APPG was 15% the max strain increased by 87%, mass loss (friability) decreased by 52%, thermal conductivity decrease from 0.033 to 0.028 W/(m·K), meanwhile the LOI can maintain above 30.
Centralizing Temporality in Adolescent and Young Adult Cancer Survivorship
Authors: Tindle Danielle , Windsor Carol , Yates Patsy
Published: September 2018

Drawing on Gadamer’s hermeneutic philosophy, this article presents a key outcome of broader research into the phenomenon of adolescent and young adult cancer survivorship. Data were generated through semi-structured interviews with 45 participants from Australia, England, and the United States. The participants received a cancer diagnosis between the ages of 15 and 29 years and were aged 18 to 40 years at the time of interview. The key analytical finding depicts the concept of time as central to the experiences in survivorship. Altered beliefs in temporal progression and biographical chronology affected the organization of time, the structuring and value of life events, and the use of time as a resource. The significance of temporality in young survivors’ experiences warrants its centrality in the design of survivorship care models that reflect a broader understanding of the life experiences of this population.
Construct of Expertise Within the Context of HRD: Integrative Literature Review
Authors: Cherrstrom Catherine A. , Bixby John
Published: September 2018

Human resource development (HRD) academics and practitioners often speak of developing expertise in individuals and unleashing expertise in organizations. For individuals, expertise has professional and personal implications related to employment, work performance, career development, career transition, and resulting livelihood across the life span. For organizations, expertise has implications for training and development; for organizational development, as a competitive advantage; and for performance. Expertise presents challenges and opportunities for HRD and merits additional research to meet such challenges and leverage opportunities to benefit individuals, teams, organization, communities, nations, and humanity. The purpose of this integrative literature review was to examine the construct of expertise within the context of HRD. Findings included where, when, and how authors used expertise in the HRD literature. Major themes comprised expertise and assessment, workforce development, professional development, leadership development, redevelopment, and elicitation and transfer. Findings have implications for theory and practice and inform future research.
Anterior Cranial Fossa Dural Arteriovenous Fistula Presenting as Recurrent Multifocal Lobar Intracerebral Hemorrhages: A Case Report
Authors: Johnson Stephen Abraham , Cox Benjamin , Ho Mai Lan , Murphy Meghan , Scharf Eugene
Published: September 2018

We report a unique case and presentation of a 77-year-old man with atrial fibrillation who presented with complex imaging features, including bifrontal cerebral hematomas that progressed to multifocal macro- and microhemorrhages, vasogenic edema, and cortical/meningeal enhancement. Cerebrospinal fluid analysis was only remarkable for a protein elevation of 65 mg/dL. Leptomeningeal vessel biopsy failed to demonstrate evidence of amyloid angiopathy but did show concentric obstructive intimal fibroplasia, suggestive of chronic venous congestion. Conventional cerebral angiography showed a Cognard type IV dural arteriovenous fistulae fed by bilateral ethmoidal arteries draining directly into ectatic cortical veins. A chronic occlusion of the anterior third of the superior sagittal sinus was also noted. The fistula was successfully surgically obliterated via an uncomplicated left frontal craniotomy approach. After rehabilitation therapy, he was discharged home with a modified Rankin Scale score of 3. Because effective treatment exists, this case underscores the importance of identifying this rare etiology of intracerebral hemorrhage and pursuing adequate workup.
Interpretation of borehole flexural measurements in high-angle wells using 3D spatial sensitivity functions
Authors: Maalouf Elsa , Torres-Verdín Carlos
Published: September 2018

Undulating wells are routinely drilled to improve reservoir exposure across hydrocarbon-bearing zones. Although conventional acoustic-log interpretation methods are reliable in vertical wells, they often yield inaccurate results when applied to high-angle or horizontal wells due to azimuthal asymmetry, spatial averaging effects, and wave-mode interference. Three-dimensional finite-difference and finite-element algorithms are typically used to quantify the aforementioned effects on acoustic logs, but they are extremely demanding on the central processing unit’s (CPU) time and memory. We develop a fast algorithm to simulate flexural slownesses acquired in high-angle wells using 3D linear spatial sensitivity functions. Spatial sensitivity functions quantify the variation of phase slowness measured by the sonic tool due to spatial perturbations of elastic properties. First, we construct 3D frequency-dependent sensitivity functions of flexural modes using the product of 1D axial, radial, and azimuthal sensitivity functions obtained from first-order approximations. Then, we simulate frequency-domain flexural logs acquired with wireline tools and dipole sources in isotropic and vertical transversely isotropic (VTI) formations penetrated by high-angle wells. For the examined examples, simulated flexural logs exhibit root-mean-square errors less than [Formula: see text] when compared with those calculated with a 3D time-domain finite-difference (3D-TDFD) algorithm. We found that in isotropic formations with layers thinner than the length of the receiver array, flexural slownesses acquired separately with cross dipoles are different because of geometric asymmetry, whereas in VTI formations we observed differences between cross-dipole slownesses because of effective anisotropy. Furthermore, the flexural logs are affected by spatial averaging introduced by the acoustic wireline tool, especially in the vicinity of layer boundaries. Three-dimensional sensitivity functions reduce the computation time of the flexural logs from an average of 15 h of CPU time per depth (using 3D-TDFD methods) to less than 3 min. The fast simulation algorithm disregards wave reflections, wave-mode conversion, and wave-mode interference occurring at layer boundaries.
Health Insurance and Human Capital: Evidence from the Affordable Care Act's Dependent Coverage Mandate
Authors: Lopoo Leonard M. , Cardon Emily B. , Raissian Kerri M.
Published: September 2018

Prior to 2010, young adults between the ages of 18 and 34 had the highest rates of uninsurance in America. The “Dependent Care Provision” of the Affordable Care Act sought to increase insurance rates among young adults by allowing them to stay on their parents' policy until age 26. We examine the human capital decisions young adults make once they have an option for health insurance outside of employer-sponsored health insurance. Using the American Community Survey from 2001 to 2016 and a difference-in-differences research design, we found that the implementation of the mandate was associated with a 3–5 percent increase in college enrollment among women 23–25 years of age. This result is robust to a variety of specifications. We did not find a consistent effect among men. Our results suggest that increased flexibility in health insurance markets has implications for human capital investment.
No Permanent Fix: MACRA, MIPS, and the Politics of Physician Payment Reform
Authors: Spivack Steven B. , Laugesen Miriam J. , Oberlander Jonathan
Published: September 2018

Organized medicine long yearned for the demise of Medicare's Sustainable Growth Rate (SGR) formula for updating physician fees. Congress finally obliged in 2015, repealing the SGR as part of the Medicare Access and CHIP Reauthorization Act (MACRA). MACRA established value-based metrics for physician payment and financial incentives for doctors to join alternative delivery models like patient-centered medical homes. Throughout the law's initial implementation, the politics of accommodation prevailed, with federal officials crafting final rules that made MACRA more favorable for physicians. However, the era of accommodation could be short-lived. The discretion that the Centers for Medicare and Medicaid Services had during the first two years of implementation is ending. Additionally, euphoria over the SGR's repeal has given way to concerns over the new program's value-based purchasing arrangements and uncertainty over their sustainability. MACRA eliminated the SGR, but not the politics of physician payment.
Improving the educational process of the University, based on the competence approach
Authors: Самсонова Майя , Samsonova Mayya
Published: September 2018

The monograph is devoted To the implementation of the competent approach in the education system. Despite the large number of works performed at the present time on the implementation of a competent approach in education, many issues remain unresolved.
The monograph studies various approaches to the implementation of the competent approach, regulatory and resource support, competence models.
The author defines the main approaches to the implementation of competencies in education, developed: the process of formation of a competence graduate in high school and the method of its planning.
Descriptive epidemiology of high TV-viewing time in Brazilian adults
Authors: Mielke Grégore Iven , Ricardo Luiza , Wendt Andrea , Christofaro Diego , Owen Neville
Published: September 2018

High volumes of daily television viewing time increase risk of cardiovascular disease and other health problems. We report the descriptive epidemiology of high (3+ hrs/day) and very high (5+ hrs/ day) television (TV) viewing time and their correlates among Brazilian adults. Data from 60,202 participants (18 more years of age) in the National Health Survey carried in 2013 were analysed. The proportions of adults spending more than 3 hours per day and more than 5 hours/day watching TV were calculated. Descriptive and adjusted analyses examined variations in the prevalence of high and very high (of TV viewing time by age, educational attainment and physical activity level, separately for men and women. Prevalence in a normal day of high TV viewing time was 28.9% and was 8.9% for very high TV time. Overall, women and those who were less educated reported more TV time than did men and the more educated. There was a slightly inverse association between physical activity practice and TV time for men but there was not a clear association between physical activity and time spent watching TV among women. Prevalence of very high TV time was 46% lower among high-educated women than their counterparts. The prevalence of high and very high TV time suggests the need to implement actions to address high levels of TV time as a prevalent leisure- time sedentary behaviour and to promote attractive active recreational options at the population level in Brazil.
PROJETO SANTOS JOVEM DOUTOR – DESDOBRAMENTOS PARA UMA APRENDIZAGEM SIGNIFICATIVA EM SAÚDE NA EDUCAÇÃO BÁSICA
Authors: Natário Elisete Gomes , Batista Maria de Lourdes Medeiros
Published: September 2018

O Projeto Santos Jovem Doutor (PSJD) busca diversas formas de incluir o cotidiano do aluno da escola pública municipal ao seu contexto educacional durante as atividades dirigidas aos seus discentes participantes e é destinado aos escolares de 8º e 9º anos do Ensino Fundamental e visa preparar alunos para protagonizarem ações vinculadas ao conhecimento do corpo humano, focando em doenças sexualmente transmissíveis, H1N1, saúde da pele, pulmão, tabagismo e drogas. Tem foco também na prática educativa, nos diversos níveis de atuação dos temas mencionados, com formação e desenvolvimento de recursos humanos (professores e alunos) e com propostas junto à comunidade. O objetivo desta pesquisa foi investigar se os desdobramentos da aprendizagem adquiridas no Projeto Santos Jovem Doutor com alunos do 8º e 9º anos do Ensino Fundamental compõe uma aprendizagem significativa no que se refere à construção de conhecimentos em saúde serem multiplicadores desse conhecimento na comunidade. Participaram deste estudo, todos os 18 estudantes que estão no Projeto Santos Jovem Doutor de uma escola pública situada na área continental de Santos - SP. Desses, 10 são alunos do 8º ano, 08 alunos do 9º ano do Ensino Fundamental II e com idades entre 13 a 15 anos. Os alunos responderam a um questionário em forma de escala de Likert na própria escola. Os resultados mostraram que o PSJD propicia uma aprendizagem significativa no que compete aos desdobramentos da mesma, ou seja, os alunos conseguiram estabelecer relações do PJDS com o seu cotidiano, com a sala de aula e estenderam seus conhecimentos sobre o corpo humano - doenças sexualmente transmissíveis, H1N1, saúde da pele, pulmão, tabagismo e drogas - a outros colegas, pais e comunidade.
#CONECTE-SE, PARTICIPE E APRENDA HISTÓRIA: RELAÇÕES ENTRE JUVENTUDE E CONHECIMENTO HISTÓRICO NO ESPAÇO ESCOLAR EM CONTEXTOS URBANOS
Authors: Cabral Maria Aparecida
Published: September 2018

O presente artigo apresenta resultados preliminares obtidos com a execução do projeto submetido à Faperj em 2017, intitulado História.com: ensino de história, fontes documentais e historiografia, voltado à inserção de estudantes do Ensino Médio em atividades científica na área da História, bem como problematiza os usos políticos das diversas mídias comunicativas, redes sociais e tecnologias da informação e comunicação (TICs) nas atividades formativas do ensino do conhecimento histórico escolar, realizados pelos jovens participantes durante os encontros de orientação. Focaliza-se um conjunto de práticas construídas nesse contexto formativo, em que a colaboração, a empatia e o protagonismo desses sujeitos tornam-se elementos fundamentais para se pensar novas perspectivas para o ensino e a aprendizagem da história escolar.
O CONSUMO DE INFORMAÇÕES SOBRE SAÚDE POR ADOLESCENTES DO 8º ANO DO ENSINO FUNDAMENTAL
Authors: Luna Tatiana , Kutianski Anatalia
Published: September 2018

O avanço tecnológico transformou a informação como um bem de consumo e com valor jurídico. O acesso à informação tornou-se fundamental nas decisões e nos rumos a serem seguidos, formando a chamada sociedade da informação que, com a popularização da mídia eletrônica e dos dispositivos móveis, passou a ter uma nova forma de leitura e consumo de informações. No presente estudo, foram realizadas coleta de dados e observações durante as aulas de Ciências do 8º ano do ensino fundamental em 2018, com 56 alunos com idade entre 13 e 17 anos, por meio de um questionário quali-quantitativo. O objetivo foi analisar como os alunos buscam e utilizam informações em saúde e indicar melhorias na proposta pedagógica voltada à promoção da saúde e qualidade de vida na escola. Conclui-se que a maioria dos alunos participantes da pesquisa não consome informações de saúde com frequência, sendo a principal fonte de informação a TV e as redes sociais, e que, na maioria dos casos, a busca por informações de saúde se dá quando estão doentes. Os dados indicam a importância de propostas pedagógicas relacionadas com a educação em saúde na escola.
JUVENTUDES, COTIDIANO E UM "CADINHO" MAIS... ENTREVISTA COM ELIANE RIBEIRO
Authors: Arcuri Christiane De Faria Pereira , Silva Lincoln Tavares
Published: September 2018

ENTREVISTA COM ELIANE RIBEIRO
LÍNGUA DE HERANÇA: LÍNGUA BRASILEIRA DE SINAIS - LIVRO DE RONICE MÜLLER DE QUADROS
Authors: Córdova Gigliola Duci
Published: September 2018

Língua de herança: língua brasileira de sinais discorre sobre a língua usada por indivíduos de comunidades em que outra língua é utilizada de forma mais abrangente. Normalmente, é uma língua de aspecto familiar. A obra reúne as experiências dos CODAs - filhos ouvintes de surdos brasileiros, bem como as pesquisas realizadas, no Brasil e em outros países, com usuários de línguas de sinais. Ademais, apresenta análises e relatos de pessoas que viveram situações de aquisição de línguas de herança. Sua leitura é riquíssima para profissionais que atuam na área e também para quaisquer interessados na cultura surda.A obra está organizada em seis capítulos. O primeiro define as línguas de herança em uma perspectiva sociolinguística. O segundo capítulo apresenta os CODAs e as comunidades de língua de herança no Brasil. O terceiro, destaca o caso da língua brasileira de sinais: língua de herança? ao tempo em que comprova a mudança de paradigma que a Libras sofreu ao longo dos anos, passando a ter mais valor linguístico, social e cultural, especialmente frente às comunidades surdas. O quarto capítulo oferece um apanhado das pesquisas com línguas de sinais como língua de herança. O quinto capítulo discorre sobre as políticas linguísticas e a língua brasileira de sinais tomando em conta de que se trata de uma língua de herança. O sexto e último capítulo revela histórias e biografias: o que os filhos ouvintes de pais surdos contam sobre as línguas, as identidades e as culturas, tendo a própria autora como coadjuvante. O livro é bom, intenso e instigante, especialmente quando inspira práticas pedagógicas de ensino de línguas. É obra indispensável a qualquer profissional desta área.
Leitura e escrita – ações libertárias
Authors: DE OLIVEIRA ROSEMARY LAPA , Da Silva Andréa Betânia da Silva Betânia , Mello Maria Alba Guedes Machado
Published: September 2018

Este artigo apresenta as ações de leitura para remição de pena para os privados de liberdade em regime fechado ou semiaberto. As ações de leitura e escrita denominada: LEITURA E ESCRITA – Ações Libertárias teve parceria com o Colégio Professor George Fragoso Modesto, situada no Complexo Prisional Lemos Brito, sediada em Salvador-Ba e abarcou duas turmas de sentenciados. A ação foi apresentada na modalidade de curso de extensão, chancelado pela Universidade do Estado da Bahia – UNEB e priorizou o espírito de valorização dos diferentes momentos e tipos de aprendizagem associado à oferta de ações complementares de constituição de sujeitos leitores no contexto prisional, considerando experiências pioneiras no Brasil. A proposta de constituição de leitores intercríticos, autônomos e situacionados entende que a leitura conduz o sujeito a considerar várias possibilidades de atribuições de sentidos aos textos; que ler é processo de elaboração/criação constante de nossas vidas, de nossas práticas; e que, nesse processo, o contexto interfere na compreensão do sujeito, mas não é determinante. O curso de extensão Leitura e Escrita: Ações Libertárias foi oferecido com carga horária de 60 horas, entre os dias 08 de agosto a 14 de dezembro de 2017, nas dependências do Complexo Prisional Lemos Brito, através da metodologia de rodas de leitura. Os resultados obtidos, além de remir a pena em duas semanas para os privados de liberdade, promoveu o enleituramento dos cursistas e o desejo da aprendizagem cada vez maior da decifração do código linguístico e da apropriação da leitura autônoma e crítica.
Kollektive Identitäten
Authors: Delitz Heike
Published: September 2018

Kollektive Identitäten sind nicht nur ein aktuelles gesellschaftliches Thema - sondern auch ein grundlegendes sozial- und kulturwissenschaftliches Konzept: Was ist und wie entsteht ein »Kollektiv« oder eine »Gesellschaft« und wie hängen individuelle und kollektive Identität zusammen? Der Band durchquert verschiedene Disziplinen und Debatten und geht dabei der Brisanz und Aktualität kollektiver Identität ebenso nach wie der Vielfalt, in der sie gedacht, erforscht und kritisiert wird - und mündet in der These der Notwendigkeit und Unmöglichkeit kollektiver Identität. Die Einführung richtet sich an Studierende der Sozial- und Kulturwissenschaften ebenso wie an alle gesellschaftlich Interessierten und Engagierten.
Preparation of an Active Ni2B/SBA-15 Catalyst to Improve NaBH4 Hydrolysis for Hydrogen Generation
Authors: Wu Fei , Li Ting , Chen Jindan , Yang Xiu Ru , Li Cheng Ming , Fan Mei Qiang , Shu Kang Ying
Published: September 2018

Ni2B nanoparticle distributed on ordered SBA-15 mesoporous silica was prepared in situ and its catalytic activity for NaBH4 hydrolysis was investigated in the presented paper. The problem of Ni2B aggregation is resolved and the catalytic activity of Ni2B is also improved due to the effect of SBA-15. The catalytic activity increases with Ni2B/SBA-15 weight ratio increased from 1:4 to 2:1 and the catalyst with Ni2B/SBA-15 weight ratio of 2:1 has high catalytic activity close to that of Ni2B. The sintered experiment shows that the catalytic activity comes from amorphous Ni2B, not crystalline Ni2B. High sintering temperature leads to the conversion from amorphous Ni2B to crystalline Ni2B and damages the nanostructure of amorphous Ni2B framework.
Degradation of AlGaN/GaN Light Emitting Diodes caused by Carbon Contamination with Reverse-bias Stress Test in Water Vapor
Authors: Chen Hsiang , He Yun Yang , Lin Min Han , Lin Shang Ren , Hung Sheng-Hao , Hsieh Kun Min , Tsai Shin-Jie , Chu Yu-Cheng
Published: September 2018

Resolving failure origins of AlGaN/GaN light emitting diodes (LED) has received intensive study recently. In this study, formation of GaCO3 caused by carbon contamination may result in deformation of the electrode near the surface and degrade the device. The electrochemical reactions may cause device damages. Degradation in electrical properties is observed in I-V characteristics. Forward-bias and reverse-bias EL images are used to trace the damaged areas. Furthermore, focus ion beam (FIB), scanning electron microscope (SEM), energy dispersive X-ray diffraction (EDX) are applied to examine the damaged areas. Results indicate that formation of GaCO3 may deform the electrode, generate the reverse-bias EL and cause the degradation.
Electrode Properties of Todorokite-type Tunnel-structured Manganese Oxide for Calcium Secondary Batteries
Authors: Suzuki Shinya , Kato Tsubasa , Kawabata Hidetoshi , Miyayama Masaru
Published: September 2018

The electrode properties of todorokite-type tunnel-structured manganese oxides (TodMO) were examined for their potential use as cathode materials in calcium batteries. TodMO with a chemical composition of Mg0.19Na0.07MnO2·0.37H2O was prepared through hydrothermal treatment of layer-structured manganese oxide using magnesium ions as interlayer guest ions. The TodMO exhibited a dis-charge and charge capacity of 100 and 80 mAh g−1, respectively, at a relatively large current density of 100 mA g−1. The reaction mecha-nism was studied in detail using X-ray absorption spectroscopy measurements. Consequently, it became clear that the newly formed Mn3+-compound converted from TodMO is responsible for the reversible capacity.
Significant Improvement of Electrochemical Performance of Ni-rich Cathode Material by Polyethylene Coating
Authors: Jang Byeong-Chan , Son Jong-Tae
Published: September 2018

We attempted to use polyethylene (PE) to coat the surface of the cathode material in order to suppress these unnecessary reac-tion, and the results obtained via electrochemical impedance spectroscopy (EIS) suggest the growth of the SEI resistance and charge trans-fer resistance was suppressed in the samples consisting of 0.1 wt% PE-coated Li[(Ni0.6Co0.1Mn0.3)0.36(Ni0.80Co0.15Al0.05)0.64)]O2 (NCS). The initial discharge capacity of the coated material was of 190.56 mAhg-1 at 0.1 C between 3.0 and 4.3 V, and 94.6 % of this capacity was retained after 30 cycles. A notable of effect of the PE coating, is that the resulting exothermic temperature appears at approximately 258.1 °C, which is higher than that for bare NCS at 249.3 °C.
Ethanol - Tolerant Pt-free Cathode Catalysts for the Alkaline Direct Ethanol Fuel Cell
Authors: Chaiburi Chakkrapong , Cermenek Bernd , Pichler Birgit Elvira , Grimmer Christoph , Schenk Alexander , Hacker Viktor
Published: September 2018

The structure and electrochemical activity of carbon supported Pt-free cathode catalysts (Ag/C, Mn3O4/C and AgMnO2/C) are investigated by means of transmission electron microscopy (TEM), energy dispersive X-ray spectroscopy (EDX), X-ray diffraction (XRD) and cyclic voltammetry (CV). The catalysts display ethanol-tolerance for the oxygen reduction reaction (ORR) in 0.1 M KOH electrolyte containing ethanol at different temperatures. Because crossover of ethanol from anode to cathode through the membrane can occur in alkaline direct ethanol fuel cells (ADEFCs), selectivity of the cathode catalyst is of high importance. AgMnO2/C catalyst exhibits the highest catalytic activity toward ORR in presence of alkaline electrolytes containing ethanol.
A Green and Efficient Michael Addition of Indoles to α, β-unsaturated Electron-deficient Compounds and Synthesis of Bis-indolylmethanes Catalyzed by Gallium Dodecyl Sulfate [Ga(DS)3] in Water
Authors: Jiang Jing , Cai Yuan , Tang Lixin
Published: September 2018

α, β-unsaturated electron-deficient compounds and bis-indolylmethanes were successfully synthesized by gallium dodecyl sul-fate (Ga(DS)3) catalyzed Michael addition using indoles and α, β-unsaturated ketones(or aldehyde) as reactant, respectively. The samples were characterized by 1H NMR (400 MHz), HRMS, and Electrothermal Digital Melting-point. The results showed that the α, β-unsaturated electron-deficient compounds and bis-indolylmethanes could be effectively catalyzed by using Ga(DS)3 to give the corresponding adducts in good to excellent yields in water media.
Investigations of Electro-hydrothermally Grown ZnO Nanostructures on Copper Grids
Authors: Tzu-Yi Yu Tzu-Yi Yu , Hung Chen Hao , Lee Yu Shan , Lin Chia Feng , Su Wei Min , Lu Chien-Cheng , Weng Cheng-Yuan , Wu Yewchung Sermon , Wu Pei Yu , Chen Hsiang
Published: September 2018

Two types of ZnO nanostructures were electro-hydrothermally deposited on mesh 100 and 200 copper grids. To investigate the nanostructures, multiple material analyses were used to analyze the material properties. FESEM images indicate that nanoflow-ers/nanorods could be grown on the mesh 100 copper grids while a single layer of ZnO nanorods could be grown on the mesh 200 copper grids. Since the size of the grid holes might influence the chemical reactions during the growth of the nanostructures, all the other material analyzes also reveale1 distinct material characteristics of these two types of nanostructures on the copper grid. Based on the experimental results, modulating the ZnO nanostructure will be helpful for future applications of ZnO nanostructures on copper substrates.
Design and Development of a Real-time Characterization System for Energy Conversion Devices
Authors: Riquelme A. J. , Sebastian P. J. , Gamboa S. A. , Campos J.
Published: September 2018

In this communication it is presented an electronic system for acquiring data from experimental energy conversion devices such as solar cells and fuel cells for micro-electronic applications. The electronic system consists of a software installed in a personal computer and an electronic circuit coupled to a four-wire terminal where the electrical variables like voltage and current can be measured from experimental cells. The software contains a feedback control system for allowing the maximum power transfer from the energy conversion device to the electrical load. It is possible to record and plot the obtained data in real time for a dynamic analysis of the experimental devices at transient or stable state conditions. It is a portable and low-cost device useful for educational and research purposes.
Pharmacological Potential of Endothelin Receptors Agonists and Antagonists
Authors: Patočka Jiří , Měrka Vladimír , Hrdina Vratislav , Hrdina Radomír
Published: September 2018

Endothelins are potent predominantly vasoconstricting agents that act as local autocrine and paracrine mediators. Endothelin-1 is the most potent and sustained vasoconstrictor and pressor substance yet identified. Abnormalities of the endothelin system occur in a range of diseases associated with vasoconstriction, vasospasm, and vascular hypertrophy. ET receptor antagonists were until recently regarded as drugs of great promise in patients with congestive heart failure, pulmonary hypertension and others. The aim of this article is a survey of compounds that affect the endothelin receptors and clinical trials with these agents.