bluuebunny/crossref_metadata_2025 huggingface dataset:
Perspectives of Italian Physicians and Patients in the Treatment of Otitis Externa: A Real-Life Study
Authors: Gelardi Matteo , Giancaspro Rossana , Landi Massimo , Santoiemma Luigi , Balestra Maddalena , Cassano Michele , Rizzo Roberta
Published: June 2023

(1) Background: Otitis externa (OE) is a common inflammatory disease of the external ear canal. Given the numerous manifestations of OE, the high rate of recurrence of the disease, as well as the emergence of resistance to antibiotics, therapeutic strategies are numerous and still not well standardized. The aim of this study was to investigate the patient journey of Italian patients suffering from OE, paying greater attention to new therapeutic options. (2) Methods: We conducted a national survey to evaluate the characteristics of patients affected by OE and to analyze the most-prescribed treatments. (3) Results: OE is a common, often relapsing disease that has several clinical manifestations. Prior to observation, the combination of corticosteroids and topical antibiotics was the most common therapeutic strategy. At the time of observation, new liposomal ozone-based preparations were the most-prescribed treatment. (4) Conclusions: This multi-center study investigated key aspects of the OE patient journey, highlighting the growing problem of antibiotic resistance. Restoring a correct ear microbiome is the therapeutic goal. In this context, new liposomal ozone-based drugs represent a promising therapeutic strategy.
Developing L2 Intercultural Competence in an Online Context through Didactic Audiovisual Translation
Authors: Rodríguez-Arancón Pilar
Published: June 2023

Developing intercultural competence is one of the most important aspects when mastering a second language (L2, henceforth). This can be achieved through different approaches, but this paper focuses on the possibility of acquiring this skill online through the use of Didactic Audiovisual Translation (DAT). Here, we present the findings of the TRADILEX Project, which has produced data that support the ability of DAT to encourage motivation in learners while they develop integrated L2 skills in general and intercultural competence in particular through a combination of intrinsic and explicit cultural components presented in different lesson plans.
The Strange Case of the Gallo-Italic Dialects of Sicily: Preservation and Innovation in Contact-Induced Change
Authors: De Angelis Alessandro
Published: June 2023

The Gallo-Italic dialects widespread within central–eastern Sicily represent the result of the medieval immigration of settlers from southern Piedmont and Liguria, after the Norman conquest of the island (1061–1091). As far as the language spoken by these communities is concerned, an oddity arises: most of their lexical and syntactic features developed further through contact with neighboring varieties (such as, most notably, Sicilian), whereas, at a phonetic/phonological level, they have remained very conservative, largely maintaining their original northern characteristics. In the present paper, the possible causes underlying such a split are discussed: if the transfer of syntactic structures can be triggered by the presence of bilingual speakers who become progressively dominant (that is, more proficient) in Sicilian as L2, the preservation of the main phonetic/phonological features can represent a tool employed to the ends of emphasizing the identity of these new settlers from both an ethnic and linguistic perspective.
On the Fabrication of High-Performance Additively Manufactured Copper Winding Using Laser Powder Bed Fusion
Authors: Abdelhafiz Mohamed , Emadi Ali , Elbestawi Mohamed A.
Published: June 2023

Due to its exceptional electrical and thermal conductivity, pure copper is frequently employed in industry as the base metal for thermal management and electromagnetic applications. The growing need for complicated and efficient motor designs has recently accelerated the development of copper additive manufacturing (AM). The present work aims to improve the power density of the copper laser powder bed fusion (Cu-LPBF) coil by increasing the slot-filling factor (SFF) and the electrical conductivity. Firstly, the dimensional limitation of Cu-LPBF fabricated parts was identified. Sample contouring and adjusting beam offset associated with optimum scan track morphology upgraded the minimum feature spacing to 80 μm. Accordingly, the printed winding’s slot-filling factor increased to 79% for square wire and 63% for round wire. A maximum electrical conductivity of 87% (IACS) was achieved by heat treatment (HT). The electrical impedance of full-size Cu-LPBF coils, newly reported in this study, was measured and compared with solid wire. It can reflect the performance of Cu-LPBF coils (power factor) in high-frequency applications. Furthermore, surface quality benefited from either sample contouring and HT, where the side surface roughness was lowered by 45% and an additional reduction of 25% after HT.
Behavioral Evaluation of Strengthened Reinforced Concrete Beams with Ultra-Ductile Fiber-Reinforced Cementitious Composite Layers
Authors: Khan Mohammad Iqbal , Abbas Yassir M.
Published: June 2023

In the literature, there is little information available regarding the behavior of composite beams made up of reinforced concrete (RC) and ultra-ductile fiber-reinforced concrete (UDFRC). In this study, UDFRC was examined for its effectiveness in enhancing the strength of RC beams. With a tensile strength of 4.35 MPa and a strain capacity of 2.5%, PVA-based UDFRC was prepared. The performance of 12 medium-sized reinforced concrete (RC) beams was measured under four-point flexural loading. The beams measured 1800 mm long, 150 mm wide, and 200–260 mm deep. The experimental program on beam specimens was divided into two phases. In the first, four 150 × 200 × 1800 mm RC beams with UDFRC layer thicknesses of 0, 30, 60, and 90 mm were tested. Additionally, four concrete and four concrete–UDFRC beams were investigated, measuring 150 × 230 × 1800 mm and 150 × 260 × 1800 mm, respectively. The study focused on medium-sized, slender RC beams under quasi-static loads and room temperature with additional or substituted UDFRC layers. As a result of replacing concrete with UDFRC, the load-carrying capacity at first crack and steel yield significantly increased between 18.4 and 43.1%, but the ultimate load-carrying capacity increased only in the range of 6.3–10.8%. Furthermore, beams with additional UDFRC layers could carry 30–50% more load than their concrete counterparts. An RC-UDFRC beam had a load-carrying capacity 10–15% greater than that of a comparable RC beam. Generally, there is a lower deflection response in UDFRC–concrete composite RC beams than in control concrete beams. The UDFRC layering can potentially improve the load-carrying capacity of RC beams, at least when ductility provisions are considered.
Study on Load Transfer Mechanism of Local Curved Prestressed Hollow-Core Slab Bridge
Authors: Chen Jihao , Wang Yuxin , Zhu Qian
Published: June 2023

The assembled hollow-core slab bridge is the most widely used beam bridge in China. With the increasing traffic volume and traffic load in China, the joints of the hollow-core slab bridge are prone to damage. In this paper, a hollow-core slab bridge with locally curved prestressed tendons is proposed. Based on the static load test of a beam with joints taken from the cross section of a hollow-core slab bridge in practical engineering, a finite element nonlinear analysis is used to simulate the test, and the concrete and interface parameters under the correct analysis results are obtained. Finally, the parameters are applied to the three-beam and two-joint hollow-core slab bridge with a span of 10 m and a finite element analysis is carried out to explore the total failure process and performance improvement effect of the prestressed hollow-core slab bridge. The results show that the interface unit method can successfully simulate the new-to-old concrete interface where the joint is in contact with the precast beam segment. Compared with the static load test results, the analysis error of each finite element model is basically within 15%. Compared with the traditional hollow-core slab bridge, the cracking load, through-joint load, and ultimate load of the prestressed hollow-core slab bridge are increased by 50.0%, 91.7%, and 66.7%, respectively. Under the same load, the stress of the U-bar, the relative deflection of both sides of the joint, and the maximum width of the joint of the prestressed hollow-core slab bridge are lower than those of the traditional hollow-core slab bridge. When the ultimate load is reached, the longitudinal crack lengths of the traditional hollow-core slab bridge and the prestressed hollow-core slab bridge are 0.48 L and 0.4 L, respectively, and the damage degree of the prestressed hollow-core slab bridge is lower than that of the traditional hollow-core slab bridge.
Biochar from Grapevine Pruning Residues as an Efficient Adsorbent of Polyphenolic Compounds
Authors: Prelac Melissa , Palčić Igor , Cvitan Danko , Anđelini Dominik , Repajić Maja , Ćurko Josip , Kovačević Tvrtko Karlo , Goreta Ban Smiljana , Užila Zoran , Ban Dean , Major Nikola
Published: June 2023

Agricultural waste, which is produced in large quantities annually, can be a threat to the environment. Biochar (BC) production represents a potential solution for reducing the amount of grapevine pruning residues and, accordingly, the impact on the environment and climate change. Biochar produced by the process of pyrolysis from grapevine pruning residues was investigated and characterized to be applied as an adsorbent of polyphenolic compounds with the aim of using the waste from viticultural production to obtain a quality product with adsorption and recovery potential. Standards of caffeic acid (CA), gallic acid (GA), and oleuropein (OLP) were used as polyphenolic representatives. The obtained data were fitted with the Langmuir and Freundlich isotherms models to describe the adsorption process. The best KL (0.39) and R2 (0.9934) were found for OLP using the Langmuir model. Furthermore, the adsorption dynamics and recovery potential of BC were investigated using an adapted BC column and performed on an HPLC instrument. The adsorption dynamics of biochar resulted in the adsorption of 5.73 mg CA g−1 of BC, 3.90 mg GA g−1 of BC, and 3.17 mg OLP g−1 of BC in a 24 h contact. The online solid phase extraction of the compounds performed on an HPLC instrument yielded a recovery of 41.5 ± 1.71% for CA, 61.8 ± 1.16% for GA, and 91.4 ± 2.10% for OLP. The investigated biochar has shown a higher affinity for low-polar compound adsorption and, consequently, a higher polar compound recovery suggesting its potential as an efficient polyphenolic compound adsorbent.
Case Study of Additively Manufactured Mountain Bike Stem
Authors: Véle Filip , Ackermann Michal , Macháček Jakub , Šafka Jiří
Published: June 2023

This article is focused on a case study of the topology optimisation of a bike stem manufactured by selective laser melting (SLM) additive technology. Topology optimisation was used as a design tool to model a part with less material used for transferring specific loads than the conventional method. For topology optimisation, Siemens NX 12 software was used with loads defined from the ISO 4210-5 standard. Post-processing of the topology-optimised shape was performed in Altair Inspire software. For this case study, the aluminium alloy AlSi10Mg was selected. For qualitative evaluation, the mechanical properties of the chosen alloy were measured on the tensile specimens. The design of the new bike stem was evaluated by Ansys FEA software with static loadings defined by ISO 4210-5. The functionality of the additively manufactured bike stem was confirmed by actual experiments defined by ISO 4210-5. The resulting new design of the bike stem passed both static tests and is 7.9% lighter than that of the reference.
Design and Manufacturing of a Novel Trabecular Tibial Implant
Authors: Zhang Yongdi , Sun Baoyu , Zhao Lisong , Yang Guang
Published: June 2023

The elastic modulus of traditional solid titanium alloy tibial implants is much higher than that of human bones, which can cause stress shielding. Designing them as a porous structure to form a bone-like trabecular structure effectively reduces stress shielding. However, the actual loading conditions of bones in different parts of the human body have not been considered for some trabecular structures, and their mechanical properties have not been considered concerning the personalized differences of other patients. Therefore, based on the elastic modulus of the tibial stem obtained from Quantitative Computed Tomography (QCT) imaging between 3.031 and10.528 GPa, and the load-bearing state of the tibia at the knee joint, a porous structure was designed under compressive and shear loading modes using topology optimization. Through comprehensive analysis of the mechanical and permeability properties of the porous structure, the results show that the Topology Optimization–Shear-2 (TO-S2) structure has the best compressive, shear mechanical properties and permeability and is suitable as a trabecular structure for tibial implants. The Gibson–Ashby model was established to control the mechanical properties of porous titanium alloy. A gradient filling of porous titanium alloy with a strut diameter of 0.106–0.202 mm was performed on the tibial stem based on the elastic modulus range, achieving precise matching of the mechanical properties of tibial implants and closer to the natural structure than uniformly distributed porous structures in human bones. Finally, the new tibial implant was printed by selective laser melting (SLM), and the molding effect was excellent.
Does Surgical Approach Influence Complication Rate of Hip Hemiarthroplasty for Femoral Neck Fractures? A Literature Review and Meta-Analysis
Authors: Filippini Matteo , Bortoli Marta , Montanari Andrea , Pace Andrea , Di Prinzio Lorenzo , Lonardo Gianluca , Parisi Stefania Claudia , Persiani Valentina , De Cristofaro Roberto , Sambri Andrea , De Paolis Massimiliano , Fiore Michele
Published: June 2023

Background: Femoral neck fractures are an epidemiologically significant issue with major effects on patients and health care systems, as they account for a large percentage of bone injuries in the elderly. Hip hemiarthroplasty is a common surgical procedure in the treatment of displaced femoral neck fractures. Several surgical approaches may be used to access the hip joint in case of femoral neck fractures, each with its own benefits and potential drawbacks, but none of them has consistently been found to be superior to the others. This article aims to systematically review and compare the different approaches in terms of the complication rate at the last follow-up. Methods: an in-depth search on PubMed/Scopus/Web of Science databases and a cross-referencing search was carried out concerning the articles comparing different approaches in hemiarthroplasty and reporting detailed data. Results: A total of 97,576 hips were included: 1030 treated with a direct anterior approach, 4131 with an anterolateral approach, 59,110 with a direct lateral approach, and 33,007 with a posterolateral approach. Comparing the different approaches, significant differences were found in both the overall complication rate and the rate of revision surgery performed (p < 0.05). In particular, the posterolateral approach showed a significantly higher complication rate than the lateral approach (8.4% vs. 3.2%, p < 0.001). Furthermore, the dislocation rate in the posterolateral group was significantly higher than in the other three groups considered (p < 0.026). However, the posterolateral group showed less blood loss than the anterolateral group (p < 0.001), a lower intraoperative fractures rate than the direct anterior group (p < 0.035), and shorter mean operative time than the direct lateral group (p < 0.018). Conclusions: The posterolateral approach showed a higher complication rate than direct lateral approach and a higher prosthetic dislocation rate than the other three types of surgical approaches. On the other hand, patients treated with posterolateral approach showed better outcomes in other parameters considered, such as mean operative time, mean blood loss and intraoperative fractures rate. The knowledge of the limitations of each approach and the most common associated complications can lead to choosing a surgical technique based on the patient’s individual risk.
Separation of n-Butanol from Aqueous Solutions via Pervaporation Using PDMS/ZIF-8 Mixed-Matrix Membranes of Different Particle Sizes
Authors: Zamani Ali , Thibault Jules , Tezel Fatma Handan
Published: June 2023

The use of mixed matrix membranes (MMMs) to facilitate the production of biofuels has attracted significant research interest in the field of renewable energy. In this study, the pervaporation separation of butanol from aqueous solutions was studied using a series of MMMs, including zeolitic imidazolate frameworks (ZIF-8)-polydimethylsiloxane (PDMS) and zinc oxide-PDMS mixed matrix membranes. Although several studies have reported that mixed matrix membranes incorporating ZIF-8 nanoparticles showed improved pervaporation performances attributed to their intrinsic microporosity and high specific surface area, an in-depth study on the role of ZIF-8 nanoparticle size in MMMs has not yet been reported. In this study, different average sizes of ZIF-8 nanoparticles (30, 65, and 80 nm) were synthesized, and the effects of particle size and particle loading content on the performance of butanol separation using MMMs were investigated. Furthermore, zinc oxide nanoparticles, as non-porous fillers with the same metalcore as ZIF-8 but with a very different geometric shape, were used to illustrate the importance of the particle geometry on the membrane performance. Results showed that small-sized ZIF-8 nanoparticles have better permeability and selectivity than medium and large-size ZIF-8 MMMs. While the permeation flux increased continuously with an increase in the loading of nanoparticles, the selectivity reached a maximum for MMM with 8 wt% smaller-size ZIF-8 nanoparticle loading. The flux and butanol selectivity increased by 350% and 6%, respectively, in comparison to those of neat PDMS membranes prepared in this study.
Investigation of High-Cycle Fatigue Properties of Wire Arc Additive Manufacturing 13Cr4Ni Martensitic Stainless Steel
Authors: Cheng Guangfu , Li Haichao , Dai Haiyan , Gao Hongming , Pang Jianchao
Published: June 2023

As one of the widely used materials for hydro turbine runners, 13Cr4Ni martensitic stainless steels (13/4 MSS) manufactured by forging and wire arc additive manufacturing (WAAM), respectively, were selected for high-cycle fatigue tests, and the effects of microstructures and defect characteristics on fatigue mechanism were investigated. The results indicate that compared to the forged 13/4 MSS, the microstructure of the WAAM test piece is very fine, and the martensite units, consequently, are smaller in size. The yield strength and ultimate tensile strength are 685 MPa and 823 MPa for the forged specimen and 850 MPa and 927 MPa for the WAAM specimens, respectively. The fatigue strength of 107 cycles at room temperature is 370 MPa for forged specimens and 468 MPa for WAAM specimens. The predominant defect of the forged 13/4 MSS specimen is inclusion, and the fatigue initiates mainly at the surface and subsurface. While for the WAAM specimen, the most commonly found defects are pores, and the fatigue initiation is internal and at the subsurface. In addition, the fine microstructure, as well as the high strength and hardness, enable the WAAM material to have higher fatigue strength. In order to assess the effect of defects on fatigue performance, the stress intensity factor and El-Haddad model were adopted in the present study. It was found that the forged specimens with fish-eye (FIE) zones and the WAAM specimens with granular bright facet (GBF) zones have longer fatigue life. The fatigue strengths of the forged 13/4 MSS were therefore predicted by defect size. In contrast, the fatigue strengths of the WAAM 13/4 MSS were predicted by both defect and GBF sizes.
Microstructure and Texture Evolution of Hot-Rolled Mg-3Gd Alloy during Recrystallization
Authors: Han Fang , Wang Hanxi , Luo Xuan , Hou Ziyong , Wu Guilin , Huang Xiaoxu
Published: June 2023

An Mg-3Gd (wt.%) sample with gradient rolling strains (ε = 0–0.55) was prepared using a wedge-shaped plate after one-pass hot rolling, allowing a high-throughput characterization of microstructure and texture over a wide strain range within one hot-rolled plate. The microstructure and texture evolutions were characterized as a function of rolling strain for the as-hot-rolled sample and as a function of annealing temperature for the subsequently annealed samples. The deformed microstructure showed a gradual change with increasing rolling strain, i.e., from a deformation twins-dominant structure in the low strain range of 0–0.20, to a shear bands-dominant structure in the higher strain range of 0.20–0.55. The recrystallization behavior during annealing showed a clear correlation between the recrystallization nucleation site and the deformed microstructure. However, a weak recrystallization texture with non-basal texture components was formed over almost the entire strain range. This work demonstrates a high-throughput experimental strategy using a wedge-shaped sample to investigate the effect of various processing parameters, such as strain and annealing temperature, on the evolution of microstructure, texture, and mechanical properties, which could accelerate the optimization of processing parameters and microstructural design.
Eco-Physiological Responses of Avicennia marina (Forssk.) Vierh. to Trace Metals Pollution via Intensifying Antioxidant and Secondary Metabolite Contents
Authors: Alharbi Basmah M. , Abdulmajeed Awatif M. , Jabbour Alae A. , Hashim Ahmed M.
Published: June 2023

Mangrove is one of the most precious ecosystems with the greatest losses due to climate change, human activities, and pollution. The objective of this study is to assess the accumulation and distribution of some trace metals (Cu, Cd, Ni, Pb, and Zn) in sediments and Avicennia marina roots and leaves and to discuss the antioxidant potential of A. marina under metallic pollution stress. Sediments, leaf, and root samples of A. marina were collected from five sites along the Red Sea Coast of Egypt. Several ecological pollution indices, including the geo accumulation index (Igeo), contamination factor (CF), pollution load index (PLI), bioconcentration factor (BCF), and translocation factor (TF), were used to assess the pollution load. Cu, Cd, Ni, Pb, and Zn average concentrations in sediments were 167.4, 0.75, 110.65, 39.79, and 220 μg g−1, respectively, and the average values of these metals in A. marina roots were 44.9, 0.5, 87.96, 39.02, and 54.68 μg g−1, respectively, while in leaves their concentration were 50.46, 0.5572, 88.24, 40.08, and 56.08 μg g−1, respectively. The values of the Igeo, CF, and PLI index indicated that location 1 and 5 are moderate-to-heavily contaminated sites. On the other hand, leaves and roots of A. marina grown in polluted locations 1 and 5 showed high accumulation of malondialdehyde (MDA), low chlorophyll a and chlorophyll b contents concomitant with a decrease in total soluble sugars. High total antioxidant capacity was associated with a significant increase in activity levels of antioxidant enzymes (Catalase, Polyphenol oxidase, Polyphenol peroxidase, and Ascorbic acid oxidase), accumulation of secondary metabolites (total phenols, flavonoids, and tannins), and proline and carotenoids content increase. Overall, the present study suggests that the mangrove habitat of the Egyptian Red Sea coast is under the stress of anthropogenic activities, which necessitates a conservation plan to avoid further contamination and protect the unique biota of this distinctive habitat.
Design and Development of Ultrabroadband, High-Gain, and High-Isolation THz MIMO Antenna with a Complementary Split-Ring Resonator Metamaterial
Authors: Armghan Ammar , Aliqab Khaled , Alsharari Meshari , Alsalman Osamah , Parmar Juveriya , Patel Shobhit K.
Published: June 2023

The need for high-speed communication has created a way to design THz antennas that operate at high frequencies, speeds, and data rates. In this manuscript, a THz MIMO antenna is designed using a metamaterial. The two-port antenna design proposed uses a complementary split-ring resonator patch. The design results are also compared with a simple patch antenna to show the improvement. The design shows a better isolation of 50 dB. A broadband width of 8.3 THz is achieved using this complementary split-ring resonator design. The percentage bandwidth is 90%, showing an ultrabroadband response. The highest gain of 10.34 dB is achieved with this design. Structural parametric optimization is applied to the complementary split-ring resonator MIMO antenna design. The designed antenna is also optimized by applying parametric optimization to different geometrical parameters. The optimized design has a 20 µm ground plane, 14 µm outer ring width, 6 µm inner ring width, and 1.6 µm substrate thickness. The proposed antenna with its broadband width, high gain, and high isolation could be applied in high-speed communication devices.
Hydrothermal Growth of an Al-Doped α-Ga2O3 Nanorod Array and Its Application in Self-Powered Solar-Blind UV Photodetection Based on a Photoelectrochemical Cell
Authors: Guo Jing-Chun , Sun Guang-Wu , Fan Ming-Ming , Fu Xu-Cheng , Yao Jia-Jia , Wang Yu-Dong
Published: June 2023

Herein, we successfully fabricated an Al-doped α-Ga2O3 nanorod array on FTO using the hydrothermal and post-annealing processes. To the best of our knowledge, it is the first time that an Al-doped α-Ga2O3 nanorod array on FTO has been realized via a much simpler and cheaper way than that based on metal–organic chemical vapor deposition, magnetron sputtering, molecular beam epitaxy, and pulsed laser deposition. And, a self-powered Al-doped α-Ga2O3 nanorod array/FTO photodetector was also realized as a photoanode at 0 V (vs. Ag/AgCl) in a photoelectrochemical (PEC) cell, showing a peak responsivity of 1.46 mA/W at 260 nm. The response speed of the Al-doped device was 0.421 s for rise time, and 0.139 s for decay time under solar-blind UV (260 nm) illumination. Compared with the undoped device, the responsivity of the Al-doped device was ~5.84 times larger, and the response speed was relatively faster. When increasing the biases from 0 V to 1 V, the responsivity, quantum efficiency, and detectivity of the Al-doped device were enhanced from 1.46 mA/W to 2.02 mA/W, from ~0.7% to ~0.96%, and from ~6 × 109 Jones to ~1 × 1010 Jones, respectively, due to the enlarged depletion region. Therefore, Al doping may provide a route to enhance the self-powered photodetection performance of α-Ga2O3 nanorod arrays.
Numerical Simulation of Deformation in Hot Runner Manifold
Authors: Jung Jae Sung , Kim Sun Kyoung
Published: June 2023

This study simulated the deformation of a hot runner manifold and nozzle assembly during operation, aiming to address potential leaks and premature failure. Both thermal and mechanical models were used simultaneously to accurately capture system behavior. A simplified set of boundary conditions was proposed for efficient problem-solving. Analysis of the simulation results revealed that thermal deformation posed a risk of catastrophic failures and leaks. Deformation from melt pressure was relatively small compared to thermal loading, not exceeding 12%. The study provided design recommendations based on the simulation findings, guiding the development of hot runner systems for improved reliability.
Power Amplifier Design for Ultrasound Applications
Authors: Choi Hojong
Published: June 2023

A design analysis of the power amplifiers developed for ultrasound applications was conducted because ultrasound applications require different types of power amplifiers, which are one of the most critical electronic components in ultrasound systems. To generate acoustic signals using transducers, which are among the most important mechanical devices in ultrasound systems, an appropriate output voltage, current, or power signal must be produced by a power amplifier. Therefore, an appropriate design analysis of the power amplifier must be conducted to obtain the optimal performance from a transducer. In addition, because of new ultrasound research trends, such as ultrasound systems with other imaging modalities and wireless ultrasound systems, the selection of an appropriate power amplifier could improve the performance of an ultrasound system with other imaging and therapy modalities. This paper describes the design parameters of a power amplifier, including the gain, bandwidth, harmonic distortion, and efficiency. Each power amplifier has specific applications and limitations. Therefore, this review will assist design engineers and ultrasound researchers who need to develop or use power amplifiers in ultrasound applications.
Scalable Preparation of the Masked Acyl Cyanide TBS-MAC
Authors: Hinton Haley , Patterson Jack , Hume Jared , Patel Krunal , Pigza Julie
Published: June 2023

This paper describes the three-step synthesis of TBS-MAC, a masked acyl cyanide (MAC) and a versatile one-carbon oxidation state three synthon. We have developed a scalable and detailed synthesis that involves: (1) acetylation of malononitrile to form the sodium enolate, (2) protonation of the enolate to form acetylmalononitrile, and (3) epoxidation of the enol, rearrangement to an unstable alcohol, and TBS-protection to form the title compound. Both the sodium enolate and acetylmalononitrile are bench-stable precursors to the intermediate hydroxymalononitrile, which can be converted to other MAC reagents beyond TBS by varying the protecting group (Ac, MOM, EE, etc.).
Hyperoside Nanomicelles Alleviate Atherosclerosis by Modulating the Lipid Profile and Intestinal Flora Structure in High-Fat-Diet-Fed Apolipoprotein-E-Deficient Mice
Authors: Shi Yuwen , Jiang Mengcheng , Zhang Yuhang , Diao Yuanyuan , Li Na , Liu Weipeng , Qiu Zhidong , Qiu Ye , Jia Ailing
Published: June 2023

Atherosclerosis (AS) is a serious threat to human health and the main pathological basis of cardiovascular disease. Hyperoside (Hyp), a flavonoid found mainly in traditional Chinese herbs, can exert antitumor, anti-inflammatory, antioxidant, and cardiovascular-protective effects. Herein, we prepared hybrid nanomicelles (HFT) comprising Hyp loaded into pluronic F-127 and polyethylene glycol 1000 vitamin E succinate and assessed their effects on AS. To establish an AS model, apolipoprotein-E-deficient (ApoE−/−) mice were fed a high-fat diet. We then analyzed the effects of HFT on AS-induced changes in aortic tissues and metabolic markers, simultaneously assessing changes in gut flora community structure. In mice with AS, HFT significantly reduced the aortic plaque area; decreased levels of total cholesterol, triglyceride, low-density lipoprotein cholesterol, inflammatory factors, and inducible nitric oxide synthase (NOS); increased high-density lipoprotein cholesterol, endothelial NOS, superoxide dismutase, catalase, and glutathione levels; and promoted the proliferation of beneficial gut bacteria. HFT could regulate intestinal flora structure and lipid metabolism and inhibit inflammatory responses. These beneficial effects may be mediated by inhibiting nuclear factor kappa B signal activation, reducing inflammatory factor expression and improving gut microflora structure and dyslipidemia. The present study provides an empirical basis for the development and clinical application of new dosage forms of Hyp.
Photodynamic Therapy: From the Basics to the Current Progress of N-Heterocyclic-Bearing Dyes as Effective Photosensitizers
Authors: Lima Eurico , Reis Lucinda V.
Published: June 2023

Photodynamic therapy, an alternative that has gained weight and popularity compared to current conventional therapies in the treatment of cancer, is a minimally invasive therapeutic strategy that generally results from the simultaneous action of three factors: a molecule with high sensitivity to light, the photosensitizer, molecular oxygen in the triplet state, and light energy. There is much to be said about each of these three elements; however, the efficacy of the photosensitizer is the most determining factor for the success of this therapeutic modality. Porphyrins, chlorins, phthalocyanines, boron-dipyrromethenes, and cyanines are some of the N-heterocycle-bearing dyes’ classes with high biological promise. In this review, a concise approach is taken to these and other families of potential photosensitizers and the molecular modifications that have recently appeared in the literature within the scope of their photodynamic application, as well as how these compounds and their formulations may eventually overcome the deficiencies of the molecules currently clinically used and revolutionize the therapies to eradicate or delay the growth of tumor cells.
Novel Hybrid Electrode Coatings Based on Conjugated Polyacid Ternary Nanocomposites for Supercapacitor Applications
Authors: Ozkan Sveta , Tkachenko Lyudmila , Petrov Valeriy , Efimov Oleg , Karpacheva Galina
Published: June 2023

Electrochemical behavior of novel electrode materials based on polydiphenylamine-2-carboxylic acid (PDPAC) binary and ternary nanocomposite coatings was studied for the first time. Nanocomposite materials were obtained in acidic or alkaline media using oxidative polymerization of diphenylamine-2-carboxylic acid (DPAC) in the presence of activated IR-pyrolyzed polyacrylonitrile (IR-PAN-a) only or IR-PAN-a and single-walled carbon nanotubes (SWCNT). Hybrid electrodes are electroactive layers of stable suspensions of IR-PAN-a/PDPAC and IR-PAN-a/SWCNT/PDPAC nanocomposites in formic acid (FA) formed on the flexible strips of anodized graphite foil (AGF). Specific capacitances of electrodes depend on the method for the production of electroactive coatings. Electrodes specific surface capacitances Cs reach 0.129 and 0.161 F∙cm−2 for AGF/IR-PAN-a/PDPACac and AGF/IR-PAN-a/SWCNT/PDPACac, while for AGF/IR-PAN-a/PDPACalk and AGF/IR-PAN-a/SWCNT/PDPACalk Cs amount to 0.135 and 0.151 F∙cm−2. Specific weight capacitances Cw of electrodes with ternary coatings reach 394, 283, 180 F∙g−1 (AGF/IR-PAN-a/SWCNT/PDPACac) and 361, 239, 142 F∙g−1 (AGF/IR-PAN-a/SWCNT/PDPACalk) at 0.5, 1.5, 3.0 mA·cm−2 in an aprotic electrolyte. Such hybrid electrodes with electroactive nanocomposite coatings are promising as a cathode material for SCs.
A Rapid and Sensitive Stability-Indicating Eco-Friendly HPTLC Assay for Fluorescence Detection of Ergotamine
Authors: Shakeel Faiyaz , Alam Prawez , Alqarni Mohammed H. , Haq Nazrul , Bar Fatma M. Abdel , Iqbal Muzaffar
Published: June 2023

Eco-friendly liquid chromatographic methods for measuring ergotamine (EGT) are scant in the published database. Accordingly, the goal of the current study was to develop a high-performance thin-layer chromatography (HPTLC) method for fluorescence detection of EGT in commercially available tablets. This approach was based on the application of ethyl alcohol–water (80:20 v/v) as the eco-friendly eluent mixture. The fluorescence detection of EGT was carried out at 322 nm. The greenness score of the present approach was evaluated by “Analytical GREENness (AGREE)” technology. The present approach for measuring EGT in the 25–1000 ng band−1 range was linear. The present assay for fluorescence detection of EGT was validated successfully by ICH guidelines for various parameters. The method was found to be rapid, sensitive, eco-friendly, and stability-indicating. The computed AGREE index for the current strategy was 0.84, displaying outstanding greenness features. The present methodology successfully separated the EGT degradation products under forced-degradation circumstances, exhibiting its stability-indicating qualities and selectivity. An amount of 99.33% of EGT was found in commercial formulations, indicating the validity of the current method for pharmaceutical analysis of EGT in commercial products. The results showed that EGT in commercial products might be regularly measured by the existing method.
Fracturing Fluid Polymer Thickener with Superior Temperature, Salt and Shear Resistance Properties from the Synergistic Effect of Double-Tail Hydrophobic Monomer and Nonionic Polymerizable Surfactant
Authors: Shi Shenglong , Sun Jinsheng , Lv Kaihe , Liu Jingping , Bai Yingrui , Wang Jintang , Huang Xianbin , Jin Jiafeng , Li Jian
Published: June 2023

To develop high-salinity, high-temperature reservoirs, two hydrophobically associating polymers as fracturing fluid thickener were respectively synthesized through aqueous solution polymerization with acrylamide (AM), acrylic acid (AA), 2-acrylamido-2-methylpropanesulfonic acid (AMPS), nonionic polymerizable surfactant (NPS) and double-tail hydrophobic monomer (DHM). The thickener ASDM (AM/AA/AMPS/NPS/DHM) and thickener ASD (AM/AA/AMPS/DHM) were compared in terms of properties of water dissolution, thickening ability, rheological behavior and sand-carrying. The results showed that ASDM could be quickly diluted in water within 6 min, 66.7% less than that of ASD. ASDM exhibited salt-thickening performance, and the apparent viscosity of 0.5 wt% ASDM reached 175.9 mPa·s in 100,000 mg/L brine, 100.6% higher than that of ASD. The viscosity of 0.5 wt% ASDM was 85.9 mPa·s after shearing for 120 min at 120 °C and at 170 s−1, 46.6% higher than that of ASD. ASDM exhibited better performance in thickening ability, viscoelasticity, shear recovery, thixotropy and sand-carrying than ASD. The synergistic effect of hydrophobic association and linear entanglement greatly enhancing the performance of ASDM and the compactness of the spatial network structure of the ASDM was enhanced. In general, ASDM exhibited great potential for application in extreme environmental conditions with high salt and high temperatures.
Hybrid Polymer-Silica Nanostructured Materials for Environmental Remediation
Authors: Grisolia Antonio , Dell’Olio Gianluca , Spadafora Angelica , De Santo Marzia , Morelli Catia , Leggio Antonella , Pasqua Luigi
Published: June 2023

Due to the ever-growing global population, it is necessary to develop highly effective processes that minimize the impact of human activities and consumption on the environment. The levels of organic and inorganic contaminants have rapidly increased in recent years, posing a threat to ecosystems. Removing these toxic pollutants from the environment is a challenging task that requires physical, chemical, and biological methods. An effective solution involves the use of novel engineered materials, such as silica-based nanostructured materials, which exhibit a high removal capacity for various pollutants. The starting materials are also thermally and mechanically stable, allowing for easy design and development at the nanoscale through versatile functionalization procedures, enabling their effective use in pollutant capture. However, improvements concerning mechanical properties or applicability for repeated cycles may be required to refine their structural features. This review focuses on hybrid/composite polymer-silica nanostructured materials. The state of the art in nanomaterial synthesis, different techniques of functionalization, and polymer grafting are described. Furthermore, it explores the application of polymer-modified nanostructured materials for the capture of heavy metals, dyes, hydrocarbons and petroleum derivatives, drugs, and other organic compounds. The paper concludes by offering recommendations for future research aimed at advancing the application of polymer-silica nanostructured materials in the efficiency of pollutant uptake.
Quercetin and Ferulic Acid Elicit Estrogenic Activities In Vivo and In Silico
Authors: Slighoua Meryem , Amrati Fatima Ez-Zahra , Chebaibi Mohamed , Mahdi Ismail , Al Kamaly Omkulthom , El Ouahdani Khadija , Drioiche Aziz , Saleh Asmaa , Bousta Dalila
Published: June 2023

In this study, we examined the sub-acute toxicity of quercetin and ferulic acid and evaluated their effects on protein, cholesterol, and estrogen levels in vivo. Six groups of female Wistar rats were fed by gavage. The first and second groups represent the positive (Clomiphene citrate 10 mg/kg) and negative (NaCl 0.9%) control groups, while the other groups received quercetin and ferulic acid at doses of 5 and 10 mg/kg/day for 28 days. The sub-acute toxicity was monitored by examining the weights, biochemical parameters (AST, ALT, ALP, urea, and CREA), and histological changes in the kidneys and liver of the treated animals. Furthermore, the in vivo estrogenic effects were studied in terms of the serum and ovarian cholesterol levels, serum estradiol, and uterine proteins. Finally, Docking studies were conducted to evaluate the binding affinity of quercetin and ferulic acid for alpha and beta estrogen receptors. Results showed that both compounds were devoid of any signs of nephrotoxicity or hepatotoxicity. Additionally, quercetin and ferulic acid caused significant estrogenic effects evidenced by an increase of 8.7 to 22.48% in serum estradiol, though to a lesser amount than in the reference drug-treated group (64.21%). Moreover, the two compounds decreased the serum cholesterol levels (12.26–32.75%) as well as the ovarian cholesterol level (11.9% to 41.50%) compared to the negative control. The molecular docking in estrogen alpha and estrogen beta active sites showed high affinity of quercetin (−10.444 kcal/mol for estrogen alpha and −10.662 kcal/mol for estrogen beta) and ferulic acid (−6.377 kcal/mol for estrogen alpha and −6.3 kcal/mol for estrogen beta) to these receptors. This study provides promising insights into the potential use of quercetin as a therapeutic agent for the management of female fertility issues.
Effect of Cosolvent on the Vesicle Formation Pathways under Solvent Exchange Process: A Dissipative Particle Dynamics Simulation
Authors: Luo Zhonglin , Shu Zhou , Jiang Yi , Wang Biaobing
Published: June 2023

The effective control over the vesicle formation pathways is vital for tuning its function. Recently, a liquid–liquid phase-separated intermediate (LLPS) is observed before a vesicular structure during the solvent exchange self-assembly of block copolymers. Though the understanding of polymer structures and chemical compositions on the competition between LLPS and micellization has made some progress, little is known about the role of cosolvent on it. In this study, the influence of cosolvent on the vesicle formation pathways is investigated by using dissipative particle dynamics. The results show that the range of water fraction within which the LLPS is favored will be highly dependent on the affinity difference of cosolvent to water and to polymer repeat units. The change of the cosolvent–water interaction and the water fraction impact the distribution of cosolvent in the polymer domain, the miscibility between the components in the system as well as the chain conformations, which finally induce different self-assembly behaviors. Our findings would be helpful for understanding the LLPS and controlling the morphologies of diblock polymers in solutions for further applications.
New Hydrophilic Derivatives of Lasalocid and Their Complexes with Selected Metal Cations
Authors: Papsdorf Monika , Pankiewicz Radosław
Published: June 2023

Two new esters of lasalocid, that are more hydrophilic, with glucose (LasGlu) and xylitol (LasX), have been synthesized, and their complexation of monovalent cations has been studied by various spectrometric and spectroscopic methods, such as ESI mass spectrometry, 1H, 13C NMR and FT-IR. Analyses of the results confirmed the synthesis of new esters with good yields. In order to carry out further studies, it was necessary to purify them using “flash“ liquid chromatography. It was confirmed that the newly obtained molecules, as well as their complexes with lithium, sodium and potassium cations, were stabilized by a strong system of intramolecular hydrogen bonds. It was found that the hydroxyl groups of esters derived from xylitol and glucose were also involved in the complexation of cations. The results of the PM6 semiempirical calculations permitted determination of the heat of formation (HOF), and visualization of the structure of the new esters and their complexes with the cations studied. All computation results are in agreement with the spectroscopic data.
Zinc Oxide Quantum Dots May Provide a Novel Potential Treatment for Antibiotic-Resistant Streptococcus agalactiae in Lama glama
Authors: Zhou Ziyao , Zhang Ting , Chen Yixin , Zhou Xiaoxiao , Zhong Yalin , Liu Haifeng , Zhong Zhijun , Hu Yanchun , Liao Fei , Wang Xianxiang , Peng Guangneng
Published: June 2023

Streptococcus agalactiae is a significant pathogen that can affect both human beings and animals. The extensive current use of antibiotics has resulted in antibiotic resistance. In our previous research, we found that zinc oxide quantum dots (ZnO QDs) had inhibitory effects on antibiotic-resistant microorganisms. In this study, a strain of Streptococcus agalactiaeWJYT1 with a broad antibiotic-resistant spectrum was isolated and identified from Lama glama at Sichuan Agricultural University Teaching Animal Hospital. The genome for the resistance and virulence genes was analyzed. Additionally, the antibacterial effects and anti-virulence mechanism of ZnO QDs for S. agalactiaeWJYT1 were investigated. The results showed that the genome of S. agalactiaeWJYT1 is 1,943,955 bp, containing 22 resistance genes and 95 virulence genes. ZnO QDs have a good antibacterial effect against S. agalactiaeWJYT1 by reducing bacterial growth and decreasing the expression of virulence genes, including bibA, hylB, sip, and cip, which provides a novel potential treatment for S. agalactiae.
Oxidation of Cathepsin D by Hydroxy Radical: Its Effect on Enzyme Structure and Activity against Myofibrillar Proteins Extracted from Coregonus peled
Authors: Ma Mengjie , Liu Pingping , Wang Chaoye , Deng Xiaorong , Zhang Lianfu , Zhang Jian
Published: June 2023

In this study, cathepsin D was oxidized in vitro with different concentrations of H2O2, and the activity, structure, and extent of myofibrillar protein degradation by oxidized cathepsin D were evaluated. The sulfhydryl content of cathepsin D decreased to 9.20% after oxidation, while the carbonyl content increased to 100.06%. The β-sheet in the secondary structure altered due to oxidation as well. The changes in the intrinsic fluorescence and UV absorption spectra indicated that oxidation could cause swelling and aggregation of cathepsin D molecules. The structure of cathepsin D could change its activity, and the activity was highest under 1 mM H2O2. Cathepsin D could degrade myofibrillar proteins in different treatment groups, and the degree of degradation is various. Therefore, this study could provide a scientific basis for the mechanism of interaction among hydroxyl radical oxidation, cathepsin D, and MP degradation.