bluuebunny/crossref_metadata_2025 huggingface dataset:
Öğretmenlerin Mesleki Profesyonelleşme Düzeyi ile Öz-Yeterlilikleri Arasındaki İlişkinin İncelenmesi
Authors: ORAKCI Şenol
Published: July 2023

Öğretmenlerin mesleki profesyonelliğinin ve öz yeterliklerinin artması, eğitim sisteminin koyduğu hedeflere ulaşılmasına katkı sağlamaktadır. Bu bağlamda, öğretmenlerin mesleki profesyonelleşme düzeyleri ile öz-yeterlikleri arasındaki olası ilişkiyi ortaya çıkarmak bu araştırmanın temel amacını oluşturmaktadır. Bu çalışmada ilişkisel model kullanılmıştır. Araştırmanın katılımcılarını 2022-2023 eğitim-öğretim yılında Ankara'nın Yenimahalle, Çankaya, Pursaklar ilçelerinde görev yapan öğretmenler oluşturmaktadır. Araştırmaya bu ilçelerde bulunan ve ulaşılabilen toplam 332 öğretmen katılmıştır. Araştırmada veri toplama aracı olarak “Öğretmen Profesyonelizmi Ölçeği” ve “Öğretmen Özyeterlik Ölçeği” kullanılmıştır. Veriler analiz edilirken ise “Pearson Çarpım-Moment Korelasyon Katsayısı” ve “Çoklu Doğrusal Regresyon”dan faydalanılmıştır. Araştırma sonucunda, öğretmenlerin mesleki profesyonelleşme düzeylerinin aritmetik ortalamasına bakıldığında, öğretmenlerin profesyonel davranış sergileme düzeylerinin yüksek olduğu saptanmıştır. Araştırmada, öğretmenlerin öz-yeterlik düzeylerinin orta düzeyin üzerinde olduğu tespit edilmiştir. Araştırmada korelasyon analizinin sonuçları incelendiğinde ise “Öğretmen Profesyonelizmi” ile “Öğrenci Katılımı”, “Öğretim Stratejileri” ve “Sınıf Yönetimi” arasında anlamlı derecede pozitif ve güçlü ilişkiler olduğu saptanmıştır. Son olarak, araştırmanın regresyon analizi sonuçlarına göre, “Öğretmen Öz-Yeterliliği”nin alt boyutlarını oluşturan “Öğrenci Katılımı”, “Öğretim Stratejileri” ve “Sınıf Yönetimi” değişkenlerinin öğretmen profesyonelizmin düzeylerini anlamlı şekilde yordadıkları ve bu üç değişkenin öğretmen profesyonelizmine ait olan toplam varyansın %31'ini açıkladıkları saptanmıştır. Bütün bu değişkenlerin öğretmenlerin işlerini profesyonelce uygulamaları için zemin oluşturma ve fırsatlar yaratma potansiyeli sunduğu söylenebilir. Bu nedenle, söz konusu bu araştırma öğretmenlerin öz-yeterlikleri ile profesyonelleşmeleri arasındaki ilişkiyi ortaya çıkarması ve bu durumun eğitim kalitesinin artırılması açısından önemli olduğunu gözler önüne sermektedir.
Caracterización de los pacientes con linfoma Hodgkin llevados a trasplante alogénico de progenitores de la hematopoyesis en la Clínica de Marly
Authors: Gómez Calcetero Carlos Fernando , Guarín Castañeda Angie Paola , Peña Ardila Oscar Javier , Figueroa Camacho Javier Leonardo , Mora Figueroa Gloria Elena , Pinzón Leal Paula Lucía , Villamizar Licet , Pedraza Meza Enrique , Menoyo Caballero Gerson David
Published: July 2023

Objetivos: caracterizar a los pacientes con linfoma Hodgkin clásico refractario /recaído llevados a trasplante alogénico de progenitores de la hematopoyesis en la Clínica de Marly entre los años 2015 y 2022. Materiales y métodos: estudio observacional retrospectivo descriptivo de una cohorte de pacientes llevados a trasplante alogénico de progenitores de la hematopoyesis (alo-TPH) donde se describen las características sociodemográficas, clínicas, variables asociadas a la plataforma de trasplante, complicaciones y descenlaces de interés en trasplante alogénico discriminado por el tipo de donante utilizado. Las variables cuantitativas fueron descritas mediante promedio y desviación estándar previa prueba de normalidad de los datos; las variables cuantitativas fueron descritas mediante frecuencias absolutas y relativas. Se calculó la mortalidad no relacionada a recaída y la tasa global de respuesta alcanzada por tomografía o PET/CT al día +100 postrasplante. Por último, se calculó la mortalidad relacionada a recaída, la tasa de mortalidad global y la mediana de seguimiento en días.
Trasplante de progenitores hematopoyéticos utilizando un donante con infección asintomática por el virus del SARSCoV- 2
Authors: Peña Oscar , López María José
Published: July 2023

Introducción: el virus SARS-CoV-2, causante de la infección del COVID-19 tiene una alta tasa de contagio y mortalidad en pacientes mayores o inmunosuprimidos, razón por la cual las unidades de trasplante hematopoyético han tenido que extremar las medidas para evitar el contagio de los pacientes. Si bien se ha detectado ARN viral en hasta el 15 % de las personas sintomáticas, hasta donde conocemos, no se han reportado infecciones por el SARS-CoV-2 transmitidas por hemoderivados, incluyendo progenitores hematopoyéticos.
Muerte súbita por fluoropirimidinas en paciente joven con cáncer de colon
Authors: Quiroga Echeverri Alicia , González Pérez Luis Gabriel
Published: July 2023

Objetivo: describir el caso de una paciente joven con cáncer de colon manejada con adyuvante con FOLFOX6m quien presentó toxicidad simultánea neurológica y cardíaca, requirió marcapasos por paro cardíaco y taquicardia ventricular (TV).
Evaluating precipitation distributions at regional scales: a benchmarking framework and application to CMIP5 and 6 models
Authors: Ahn Min-Seop , Ullrich Paul A. , Gleckler Peter J. , Lee Jiwoo , Ordonez Ana C. , Pendergrass Angeline G.
Published: July 2023

Abstract. As the resolution of global Earth system models increases, regional-scale evaluations are becoming ever more important. This study presents a
framework for quantifying precipitation distributions at regional scales and applies it to evaluate Coupled Model Intercomparison Project (CMIP) 5 and 6 models. We employ the Intergovernmental Panel on Climate Change (IPCC) sixth assessment report (AR6)
climate reference regions over land and propose refinements to the oceanic regions based on the homogeneity of precipitation distribution
characteristics. The homogeneous regions are identified as heavy-, moderate-, and light-precipitating areas by K-means clustering of Integrated Multi-satellitE Retrievals for Global Precipitation Measurement (GPM) version 6 final run product (IMERG)
precipitation frequency and amount distributions. With the global domain partitioned into 62 regions, including 46 land and 16 ocean regions, we
apply 10 established precipitation distribution metrics. The collection includes metrics focused on the maximum peak, lower 10th percentile, and
upper 90th percentile in precipitation amount and frequency distributions; the similarity between observed and modeled frequency distributions; an
unevenness measure based on cumulative amount; average total intensity on all days with precipitation; and number of precipitating days each
year. We apply our framework to 25 CMIP5 and 41 CMIP6 models, as well as six observation-based products of daily precipitation. Our results indicate that
many CMIP5 and 6 models substantially overestimate the observed light-precipitation amount and frequency, as well as the number of precipitating
days, especially over midlatitude regions outside of some land regions in the Americas and Eurasia. Improvement from CMIP5 to 6 is shown in some
regions, especially in midlatitude regions, but it is not evident globally, and over the tropics most metrics point toward degradation.
Methods to investigate the temperature distribution of heated ceramic gas sensors for high-temperature applications
Authors: Wöhrl Thomas , Herrmann Julia , Kita Jaroslaw , Moos Ralf , Hagen Gunter
Published: July 2023

Abstract. The temperature-dependent properties of sensor films for measuring the concentration of various gas components affect, to a large extent, the sensor characteristics of planar gas sensors. Therefore, it is important to know the temperature distribution of the gas-sensitive films of such
sensors precisely. Using screen-printed thermocouples and a thermal-imaging
camera, two principles for determining the temperature profile of gas
sensors inside of a protection cap are shown and compared in this study. The
data agree well, and the results can be used in future to determine the
influences of varying flow and temperature conditions on the temperature
profile of a sensor and to reduce such effects by adapting the periphery, e.g.,
by designing appropriate protection caps.
Climate-induced storminess forces major increases in future storm surge hazard in the South China Sea region
Authors: Wood Melissa , Haigh Ivan D. , Le Quan Quan , Nguyen Hung Nghia , Tran Hoang Ba , Darby Stephen E. , Marsh Robert , Skliris Nikolaos , Hirschi Joël J.-M. , Nicholls Robert J. , Bloemendaal Nadia
Published: July 2023

Abstract. Coastal floods, driven by extreme sea levels, are one of the most dangerous
natural hazards. The people at highest risk are those living in low-lying
coastal areas exposed to tropical-cyclone-forced storm surges. Here we
apply a novel modelling framework to estimate past and/or present and future storm-surge-level and extreme-sea-level probabilities along the coastlines of southern
China, Vietnam, Cambodia, Thailand, and Malaysia. A regional hydrodynamic
model is configured to simulate 10 000 years of synthetic tropical cyclone
activity, representative of a past/present (1980–2017) and high-emission-scenario future (2015–2050) period. Results show that extreme storm surges, and therefore total water levels, will increase substantially in the coming decades, driven by an increase in the frequency of intense tropical
cyclones. Storm surges along the southern Chinese and northern and southern Vietnamese
coastlines increase by up to 1 m, significantly larger than expected changes in mean sea-level rise over the same period. The length of coastline that is presently exposed to storm surge levels of 2.5 m or greater will more than double by 2050. Sections of Cambodian, Thai, and Malaysian coastlines are projected to experience storm surges (at higher return periods) in the
future, not previously seen, due to a southward shift in tropical cyclone
tracks. Given these findings, coastal flood management and adaptation in
these areas should be reviewed for their resilience against future extreme
sea levels.
Laboratory experiments in ocean alkalinity enhancement research
Authors: Iglesias-Rodríguez Maria Debora , Rickaby Rosalind E. M. , Singh Arvind , Gately James A.
Published: July 2023

Abstract. Recent concern about the consequences of continuing increases in atmospheric CO2 as a key heat-trapping agent (USGCRP, 2017; IPCC, 2021) have prompted ocean experts to come together to discuss how to provide science-based solutions. Ocean alkalinity enhancement (OAE) is being considered not only as a ocean carbon dioxide removal (CDR) approach, but also as a potential way to mitigate ocean acidification. Over the last two decades, inter-laboratory comparisons have proven valuable in evaluating the reliability of methodologies associated with sampling and analysis of carbonate chemistry parameters, which have been routinely used in ocean acidification research (Bockmon and Dickson, 2015). Given the complexity of processes and mechanisms related to ecosystem responses to OAE, consolidating protocols to ensure compatibility across studies is fundamental for synthesis and upscaling analysis. This chapter provides an overview of best practice in OAE laboratory experimentation and facilitates awareness of the importance of applying standardized methods to promote data re- use, inter-lab comparisons, and transparency. This chapter provides the reader with the tools to (1) identify the criteria to achieve the best laboratory practice and experimental design; (2) provide guidance on the selection of response variables for various purposes (physiological, biogeochemical, ecological, evolutionary) for inter-lab comparisons; (3) offer recommendation for a minimum set of variables that should be sampled and propose additional variables critical for different types of synthesis and upscaling; and (4) identify protocols for standardized measurements of response variables.
Post-Little Ice Age rock wall permafrost evolution in Norway
Authors: Czekirda Justyna , Etzelmüller Bernd , Westermann Sebastian , Isaksen Ketil , Magnin Florence
Published: July 2023

Abstract. The ground thermal regime and permafrost development have an important influence on geomorphological processes in periglacial regions and ultimately
landscape development. About 10 % of unstable rock slopes in Norway are potentially underlain by widespread permafrost. Permafrost thaw and
degradation may play a role in slope destabilisation, and more knowledge about rock wall permafrost in Norway is needed to investigate possible links
between the ground thermal regime, geomorphological activity and natural hazards. We assess spatio-temporal permafrost variations in selected rock
walls in Norway over the last 120 years. Ground temperature is modelled using the two-dimensional ground heat flux model CryoGrid 2D along nine
profiles crossing instrumented rock walls in Norway. The simulation results show the distribution of permafrost is sporadic to continuous along the
modelled profiles. Results suggest that ground temperature at 20 m depth in steep rock faces increased by 0.2 ∘C per decade on average
since the 1980s, and rates of change increase with elevation within a single rock wall section. Heat flow direction is primarily vertical within
mountains in Norway. Nevertheless, narrow ridges may still be sensitive to even small differences in ground surface temperature and may have
horizontal heat fluxes. This study further demonstrates how rock wall temperature increase rates and rock wall permafrost distribution are
influenced by factors such as surface air temperature uncertainties; surface offsets arising from the incoming shortwave solar radiation; snow
conditions on, above and below rock walls; and rock wall geometry and size together with adjacent blockfield-covered plateaus or glaciers.
КАРАНТИННІ ТА ПРОТИЕПІДЕМІЧНІ ЗАХОДИ ЯК ГАРАНТІЇ ЗАБЕЗПЕЧЕННЯ ПРАВА ОСОБИ НА ОХОРОНУ ЗДОРОВ’Я В УКРАЇНІ
Authors: Левицький Олег Олегович
Published: July 2023

Статтю присвячено огляду питань гарантій забезпечення права особи на охорону здоров’я в Україні. Розглянуто карантинні і протиепідемічні заходи як гарантії забезпечення права особи на охорону здоров’я. Акцентується увага на тому, що протиепідеміологічна кампанія, яка була запущена на початку 2020 року з метою боротьби з поширенням пандемії COVID-19, суттєво змінила адміністративно-правовий механізм, що гарантує право людини на охорону здоров'я. В цій ситуації спостерігаються обмеження у реалізації цього та інших прав і свобод, а також велика кількість маніпуляцій, порушень правил та зловживань ситуацією. Підкреслюється необхідність юридичних гарантій полягає у забезпеченні повної реалізації прав та свобод людини й громадянина. Ці юридичні гарантії залежать від соціально-політичних, духовних та інших процесів, що відбуваються в країні на різних етапах її історичного розвитку. Вони визнають і закріплюють права та свободи людини й громадянина у Конституції України та інших нормативних актах держави, і забезпечують їх реалізацію через діяльність державних органів, суспільно-політичних організацій та осіб, що обіймають посади. Наголошується, що у вітчизняному законодавстві з питань охорони здоров'я немає положень, які б давали суб'єктам цих правовідносин більше можливостей для самостійності та розвитку підприємницької активності. Робиться висновок, що українські громадяни неактивно захищають свої права у суді та рідко звертаються до правоохоронних органів, щоб повідомити про порушення їх прав у сфері охорони здоров'я. У той же час, парламентський контроль, здійснюваний Уповноваженим з прав людини, виявився найефективнішим. Тому для покращення адміністративно-правових гарантій у досліджуваній сфері необхідно: зміцнити економічні гарантії; встановити постійний контроль над реалізацією державних програм, що забезпечують ліки, протези та інші засоби; впровадити громадський контроль у цій сфері; підвищити прозорість інформації про діяльність Міністерства охорони здоров'я України та інше. Більшість європейських країн, де передбачена можливість обмеження права на охорону здоров'я, встановили чіткі критерії і вимоги до законів, які вводять такі обмеження. Якщо обставини надзвичайні або воєнні, то підстави для їх запровадження регламентуються у конституціях. Українське конституційне законодавство використовує традиційний підхід, який є загальноприйнятним для міжнародного та європейського права. Згідно з ним обмеження конституційного права особи може бути допустиме лише тоді, коли таке обмеження призводить до усунення більш серйозної загрози, ніж неможливість реалізації відповідного права.
Reflections: Rethinking Engagement and Student Persistence
Authors: Tinto Vincent
Published: July 2023

We are delighted to feature this timely reflective article on Rethinking Engagement and Student Persistence by Professor Vincent Tinto, Distinguished University Professor Emeritus at Syracuse University, United States of America (USA).  It’s timely because six years ago Professor Tinto reflected in this Journal on Student Persistence – and that was pre-COVID, and the associated mass transition to online, flexible and hybrid learning modalities. We are delighted because during the STARS 2023 Conference, it was apparent that Professor Tinto’s work continues to inspire and guide practice as he generously offers his thoughts to practitioners and researchers who share his passion for improving student outcomes.  In this article, Vincent explores the role that social networks have in fostering student engagement, leading to persistence.  As he puts it ’engagement matters’ and indeed it does, although its impact as he says remains relatively under-explored.  Vincent considers social networks using the classroom and curriculum as contexts for understanding how different forms of networks: tight or loose, dense or sparse can engender different outcomes for students noting that the mere existence of a network will not always lead to positive student engagement. He gives attention to the formation of networks and notes that some of these connecting relationships are less visible, especially for online students and for those students whose networks exist in virtual social spaces that are outside the realm of our institution.  Acknowledging that staff cannot and should not seek to be involved in all student networks, he implores us to do what we can to foster productive networks within our spheres of influence, because put simply ‘student engagement cannot be left to chance.’
MIs in Education: A Study of High School EFL Teachers' Perspectives in the Saudi Context
Authors: Alwehebi Kholoud
Published: July 2023

The educational philosophy of Multiple Intelligences (henceforth MIs) in the English language learning context of Saudi Arabia seems to be an underexplored field. Therefore, this study aims to show from the perspective of the teachers the primary barriers that impede Saudi High School students from employing their MIs. Additionally, it examines how MI concepts influenced Saudi high school students' comprehension of EFL in language classrooms. The study demonstrates how Saudi High School EFL teachers interpret the notion of MI as an educational approach. The study sample is random, comprising 100 High School EFL teachers who teach English as a Foreign language (EFL) at Dammam city in Saudi Arabia. The research is quantitative in nature and uses a five-point Likert Scale questionnaire to collect data on EFL teachers' perspectives. Results show that teachers strongly agree with the notion that MI as an educational approach may create a negative effect in the classroom if not comprehended properly, consequently raising challenges in its application in the EFL classroom. However, the MI approach is effective in language learning if its nuances are comprehended. It is expected that these results would be of use to curriculum developers and teachers training programs geared to enhance learning.
The Impact of Spiritual Leadership and Motivational Leadership on Organizational Citizenship Behavior and Religious Performance: Evidence from Indonesian Islamic Schools
Authors: Muharom Fauzi
Published: July 2023

Integrated Islamic Kindergartens and Elementary Schools in Indonesia are highly influenced by Islam. However, some schools that aim to enhance religious performance and management still need to comprehend the role of Organizational Citizenship Behavior (OCB). In addition, there has been scare research examining the interplay among spiritual leadership, motivational leadership, religious performance, and OCB in Islamic education context. Hence, this research focuses on the effect of OCB, spiritual leadership, and spiritual motivation on religious performance. The study uses a quantitative method through survey, and a proportional random sampling technique is applied to select 203 respondents, consisting of teachers and staffs. An online questionnaire measured using five-point likert scale is employed to elicit the required data. Path analysis multiple linear regression using SPSS program is further used to interpret the data. The results of data analysis indicate that spiritual motivation and leadership have a significant effect on OCB. Furthermore, spiritual motivation and leadership also significantly affect religious performance. The analysis suggests that an increase in spiritual motivation and leadership encourages OCB and leads to better religious performance in the long run. In a broader view, this research offers fruitful insights for Islamic schools in Indonesia to enhance teachers' and staffs' religious working performance.
The effect of mechanized shelling and packaging on the quality of melon seeds
Authors: Osuji Chijioke , Uche Chioma , Iheagwara Marcquin , Ofoedu Chigozie , Omeire Gloria , Nwakaudu Angela , Ozumba Isaac
Published: July 2023

A comparative study was carried out between mechanized shelling and manual shelling of Egusi-melon seeds and the effect of different packaging materials on some quality attributes of shelled Egusi-melon seeds(Bara and Serewe). Egusi-melon seeds were manually shelled and mechanically shelled using the National Centre for Agricultural Mechanization (NCAM) mechanical melon Sheller (2018 and 2020 models) and a Rice huller (SB-10D Rice mill). Shelled Egusi-melon seeds were packaged and stored in kraft paper, glass bottles, laminated pouches, and a low-density polypropylene bag for 10 weeks. The Shelling efficiency of different machines compared to manual shelling (control) was evaluated. Manual shelling (control) was the most efficient in terms of output quality. The 2020 NCAM mechanical melon Sheller was the most efficient of the mechanized processes, while the rice huller was the least efficient. The shelled seeds were evaluated for shelling, free fatty acid, and microbial analysis. Results showed that Bara was more efficiently shelled by machines while Serewe was more efficiently shelled manually. Kraft paper seems to reduce seed spoilage over the storage period compared to the other packaging materials, the seeds shelled using the 2020 NCAM mechanical melon Sheller consistently recorded a significantly lower percentage increase in free fatty acid and fungal load. This research has provided valuable insight that selecting a suitable variety, shelling machine, and packaging material is crucial for the overall efficiency and high-quality output of large-scale production of shelled Egusi-melon.
Transforming livestock by-products into nutritious extruded feed additives: a sustainable approach for modern agriculture
Authors: Kassymbek Rabiga , Kenebay Gulmira , Chomanov Urishbay , Zhumaliyeva Gulzhan , Idayatova Marzhan
Published: July 2023

The search for a solution to the challenge of providing the agriculture industry with complete feeds is relevant to modern animal husbandry in many countries, and protein is a key limiting component in feed. Along with the growth of food production, the waste it produces, which is also a valuable resource of useful components, can be recycled and used. Thus, in slaughter, butchering and meat production, a large amount of waste is generated, including by-products that can be processed further. The extrusion process is one of the best processing methods to improve the nutritional value of ingredients and feed and improve feed efficiency. In modern feed milling operations, extrusion must be considered as the main process for increasing feed profitability. The benefits of the extrusion process in improving the nutritional value and efficiency of ingredients and feeds depend on many factors, such as the structure and chemical composition of the ingredients, the processing conditions and the equipment used in processing. This article substantiates the need to develop technologies for involving production waste in their further use in medium- and long-term growth in the demand for food. A technology for producing an extruded feed additive based on vegetable feed with the addition of slaughter waste is presented. The formulation of a feed additive in which different percentages of slaughter waste of 5.10% and 15% corn was replaced with by-products was studied. The water activity of the obtained extruded feed additives was studied, where, at a content of 15% slaughter waste, it was low compared with that of the other two samples. Further research will allow procuring fodder products with a high biological value and utilising unclaimed by-products of livestock slaughter.
Python, nuevo paradigma en la educación universitaria
Authors: Mendoza Moya Iván José
Published: July 2023

La creciente necesidad de aplicar la tecnología en la vida diaria torna cada vez más imperioso la necesidad del aprendizaje de un lenguaje de programación a fin de diseñar, elaborar o modificar intrincadas soluciones que son empleadas para el procesamiento de datos. Esto puede variar según el área de interés de cada persona, llegando a requerir un alto grado de dominio o tal vez un dominio somero de estos lenguajes. Afrontando una realidad o un árbol genealógico de los lenguajes de programación, nos muestra que se va ramificando cada vez más en alternativas genéricas o específicas. Existe una gran variedad de lenguajes de programación a pesar del nivel de formación, pero al margen de considerar como primer indicador el objetivo de uso, debe considerarse un indicador que se torna cada vez más relevante. Este indicador es la curva de aprendizaje, que clasifica a los lenguajes con un grado mayor o menor de complejidad de escritura o una sintaxis que aparenta más un lenguaje natural que un lenguaje estricto basado en normas y reglas que obedecen a sintaxis muy elaboradas. Entre los lenguajes de programación ­si se considera este último indicador como relevante­ se encuentran los lenguajes de alto nivel, donde cabe resalta el lenguaje Python que, por sus bondades, está en constante crecimiento por la aceptación de la comunidad mundial de desarrolladores. Se considera que Python es un lenguaje de alto nivel con una creciente aceptación de la comunidad mundial, por lo cual debería ser el primer lenguaje a ser aprendido por todas las personas, no importando las características iniciales de los estudiantes en los grados de formación universitaria.
Espacios de terapias urbanas con inclusión social en el área metropolitana de Cochabamba
Authors: Miranda Sanchez Carola , Miranda Castellón Daniela
Published: July 2023

El presente artículo trata de la importancia del espacio abierto (plazas, parques y áreas verdes), denominado espacios de terapia urbana con inclusión social, en el cual se realiza una revisión bibliográfica conceptual acerca de la acupuntura urbana, habitabilidad en el espacio abierto y el ambiente restaurador. De esta forma se realiza un análisis diagnóstico y recomendaciones para el diseño con inclusión social para los usuarios del área metropolitana de Cochabamba, con el objetivo de mejorar el diseño de estos espacios y beneficiar a todos los grupos sociales de la ciudad, para que tengan una mejor calidad de vida, bienestar y puedan apropiarse del espacio urbano adecuadamente.
Modelado y simulación de un robot de cuatro grados de libertad
Authors: Montaño Bautista Edson Gastón , Ramos Silvestre Edgar Roberto
Published: July 2023

El presente documento muestra paso a paso el procedimiento que se debe seguir para obtener el modelo dinámico de un robot de cuatro grados de libertad. Esto se logró con la ayuda de una herramienta matemática muy importante: las Ecuaciones de Movimiento de Lagrange. Una vez obtenidas las ecuaciones que gobiernan el movimiento del robot, se realizaron las simulaciones del modelo matemático obtenido con ayuda del software Matlab-Simulink; así mismo, se obtuvieron las gráficas de la trayectoria del extremo del robot para diversos torques aplicados a cada una de sus articulaciones. El diseño CAD del robot se realizó utilizando el software SolidWorks, esto para obtener las propiedades físicas de los eslabones como masas, centros de masa y momentos de inercia.
Propuesta de espacio interactivo de enseñanza para promover el desarrollo del diseño arquitectónico e interiorista
Authors: Barja Amusquivar Mirian Gabriela , Casso Arias Marcela Geovana
Published: July 2023

El presente trabajo pretende dar impulso al uso de aulas interactivas con las características tecnológicas con las que deben contar para generar espacios de enseñanza y desarrollo dentro de los talleres de diseño. Al hablar de características tecnológicas se hace referencia a internet de banda ancha, proyectores para tercera dimensión de 360 grados, pizarrones digitales y tabletas o celulares con acceso a plataformas de enseñanza y con posibilidades de conectarse unas con otras mediante dispositivos móviles. Es importante dentro de esta estrategia considerar la práctica docente y el buen manejo de todas estas tecnologías de enseñanza para habilitarlos a planificar y enseñar en entornos interactivos (pero esto corresponde a una segunda fase). El componente principal de esta propuesta se basa en el diseño del aula, que debiera gozar de las instalaciones necesarias para poder contar con los elementos anteriormente mencionados; constructivamente debe constar de muros perfectamente enlucidos, pisos blancos de materiales de primera calidad para la proyección propicia y la dotación de rieles en el cielo falso o losa para el movimiento de los proyectores. Estos y otros detalles más persiguen la intención de lograr espacios propicios para que se dé la  interacción dentro del aula.
Evaluación del sistema de control de gestión de la construcción e implementación de la constructabilidad en empresas constructoras de obras ci
Authors: Vásquez Salazar Elizabeth M.
Published: July 2023

Durante la ejecución de proyectos, normalmente se presentan problemas de retraso en los tiempos de ejecución, mal manejo de los recursos y mala calidad de las obras, entre otros; generando de esta forma, órdenes de cambio, contratos modificatorios y rescisiones de contratos. A esto se suma que la mayoría las entidades encargadas a nivel nacional no tienen una metodología unificada para el control de los procesos de construcción, sino que cada una maneja su propio formato que, en algunos casos, no son útiles para el control y/o intervención de las personas u organismos que ejercen la supervisión y construcción de las obras; por lo que el objetivo del presente estudio es evaluar el sistema de control de gestión e implementación de la constructabilidad en empresas de la Ciudad de Cocha bamba. La metodología del estudio consistió en la aplicación de un cuestionario a personal clave de 20 empresas constructoras de la ciudad de la Cochabamba, totalizando 57 encuestas. Los resultados muestran que no todas las empresas presentan una gestión adecuada para la construcción de sus obras y un desconocimiento del término "constructabilidad"; sin embargo, la mayoría de las empresas está dispuesta a implementarla a fin de mejorar la productividad de sus procesos.
Obtención de bioetanol a escala piloto como aditivo de la gasolina especial y prefactibilidad de instalación, fase II
Authors: Justiniano Ayarde Lrina , Andrade Delgadillo Carla , Apaza Rojas Carla , Siles Martha
Published: July 2023

El objetivo de la presente investigación consiste en validar un proyecto de obtención de bioetanol a escala piloto a partir de materias primas alternativas (mango, banano y maíz) disponibles en el Departamento de Cocha bamba, Bolivia. Se proyecta una producción de bioetanol de 540 litros al año, las optimizaciones de los sistemas de separación y del proceso de fermentación permitieron producir alcohol anhidro al 99,60/ov/v de pureza. Se determinaron los parámetros de dimensionamiento de la planta piloto y se llevó a cabo la simulación del sistema de separación que comprende los procesos de destilación y deshidratación en el software Aspen HYSYS ® v. 8.0. El análisis fisicoquímico realizado -además de permitir la caracterización del Bioetanol, Gasohol E-10 y gasolina especial- proporcionó la información necesaria para determinar el uso del alcohol anhidro como aditivo de la gasolina. Los resultados obtenidos revelaron que las distintas propiedades se encuentran dentro de los parámetros establecidos en la norma ASTM 04806 y las normativas correspondientes según la Comisión Económica para América Latina y el Caribe, 2006. Los resultados de la investigación proponen la producción de alcohol anhidro que cubriría un porcentaje de la demanda departamental anual del nuevo combustible Súper Etanol 92, el costo de producción es Bs.120,85 por litro de etanol anhidro al 99,6 % y la recuperación de la inversión en 9 años.
Análisis del flujo de la mazamorra de Tiquipaya - Bolivia 2018: identificación de causas, riesgos y acciones
Authors: Le Noir Claude , Cayo Chileno Nahúm Gamalier , Sánchez Miranda Héctor Luis , Arrázola Brañez Alex Isaac , Terán Camacho José Gabriel , Noel Zampieri Jesús Gilbert
Published: July 2023

En el mes de febrero 2018, el Municipio de Tiquipaya - Bolivia fue afectado por un flujo de mazamorra a partir del ingreso del Río Taquiña a su cuenca baja, provocando inundaciones y acumulaciones de mazamorras de gran magnitud. El estudio de dicho acontecimiento es importante ya que con las medidas de prevención adecuadas se logrará disminuir/evitar futuros eventos similares. Este artículo tiene por objetivo dar a conocer las principales causas del flujo de mazamorra, además sugerir medidas preventivas a través de investigación internacional, consulta de datos y análisis, empleando la información necesaria de las instituciones públicas afines.
Reducción de emisiones de carbono mediante el Blending de hidrogeno/gas natural en las redes de distribución de gas natural de Bolivia
Authors: Panozo Villca Henry , Canelas Jaimes Edgar
Published: July 2023

La búsqueda de la descarbonización por el alto consumo de combustibles fósiles en la generación eléctrica y los procesos industriales mismos que representan más de un tercio de las emisiones globales de gases de efecto invernadero (GEI), consideramos al hidrogeno un combustible limpio, sostenible y con un índice de contaminación, ya que no solo se puede usar como vector energético, sino también como materia prima para contribuir a la descarbonización del planeta. El reemplazo del Gas Natural por Hidrogeno es una alternativa que está sujeta a las limitaciones de diseño en la red de distribución de gas natural. Por lo tanto, previo al blending de hidrogeno, se debe realizar un estudio completo de los sistemas de tuberías y todos los equipos secundarios. Este articulo presenta la revisión bibliográfica de las diferentes fuentes de obtención de hidrogeno y parámetros para el blending de hidrogeno en las redes de distribución de gas natural de Bolivia para la reducción de emisiones de carbono y enriquecimiento del gas natural. Aportando a 5 de los 17 Objetivos desarrollo sostenible planteados por la Organización de las Naciones Unidas (ONU). Palabras Clave: Blending. Hidrógeno. Gas natural. Descarbonización. Inyección de hidrógeno en tuberías de gas natural. Reducción de emisiones de carbono. Abreviaturas: Hidrógeno ( ), dióxido de carbono ( ), inyección de hidrógeno en las redes de gas natural (HIGG), reformado de metano con vapor (SMR); reformado autotérmico (ATR); Captura y almacenamiento de carbono (CCS), gas natural licuado (GNL).
Clinical and etiological features of hydrocephalus in infants
Authors: Kositov D. D. , Rakhmonov H.  J. , Berdiev R. N. , Rakhmonov U. H.
Published: July 2023

Aim. To analyze the causes and clinical course of hydrocephalus in infants and its association with various etiological factors.

Materials and Methods. The study involved a retrospective analysis of data from 47 infants who were hospitalized in the Pediatric Neurosurgery Department of the Republican Scientific Center of Neurosurgery named after Shifobakhsh between the years 2020 and 2022. The patients were evaluated using a comprehensive range of diagnostic techniques, including CT, MRI, neuro-ophthalmoscopy, and neurosonography.

Results. Among the infants with hydrocephalus, infectious-inflammatory CNS diseases were identified as the primary cause in 23 cases (48.9%), cranial-brain trauma in 12 cases (25.6%), brain tumor processes in 7 cases (14.9%), and congenital factors in 5 cases (10.6%). All 47 (100%) patients presented with generalized cerebral symptoms and exhibited signs of hypertensive-hydrocephalic syndrome.

Conclusion. Our findings demonstrate that hydrocephalus in infants most commonly develops following the occurrence of infectious-inflammatory CNS diseases, while congenital causes are relatively less prevalent. The investigation of the clinical features and etiology of hydrocephalus enables the selection of appropriate diagnostic strategies and optimal surgical treatment methods.
Focal dystonia after an ischemic stroke: case report
Authors: Nakano Bruno Eiji , Cavasana Gabriel Flamarin , Nakazato Paula Carolina Grande , Chinelato Sarah de Souza , Irikura Rodrigo Batista , Silva Bruna Santos , Colognesi Anouar Sacca , Migueis Isabella Brasileiro Quintella , Viveiros Gustavo Carvalho , Stefano Luiz Henrique Soares Santos , Pereira Fabio de Araujo , Melges Natalia Samadello , Nakano Thaline Tiemi
Published: July 2023

Case presentation: A 77-year-old female patient, previously hypertensive, was admitted to the emergency room due to involuntary movements in the right upper limb onset one day ago with no other associated complaints. During neurological examination she presented hemiparesis and hypoesthesia in the right dimidium of the body besides involuntary movements in the ipsilateral hand. Skull magnetic resonance imaging evidences hyperintensity on T2/ FLAIR sequences in areas of periventricular and left parietal white matter in accordance to a previous ischemic event. Discussion: Dystonia is a movement disorder caused by involuntary muscle contractions leading to repetitive or abnormal movements. It is related to hereditary, idiopathic or acquired causes, including the ones related to brain lesions of cerebrovascular etiologies, such as ischemia, hemorrhage and arteriovenous malformation and aneurysm. The diagnosis of dystonia is made clinically. The treatment consists of the application of botulinum toxin, oral medications such as clonazepam and baclofen. Conclusion: A challenge due to the numerous etiologies involved, dystonias are movement disorders that negatively impact patients’ self-esteem and independence. The present case is extremely relevant considering there was no reported prior complaint of focal neurological deficit, although an area consistent with cerebral ischemia was identified on cranial magnetic resonance imaging, correlated as the causative factor leading to the involuntary movement.
Pseudotumor demyelination lesion associated with bevacizumab in oncological treatment
Authors: Silva Agnes Laura , Pinheiro Beatriz Iolanda de Sene Ferregutti , Silva Laura de Lourdes Cardoso e , Pennisi Elisa Santos , Vitorino João Augusto Nunes , Pena Vinicius Moura Abbud , Barbieri Raul Fernando Pinsetta , Copati Florença Neves , Santos Diogo Fernandes dos
Published: July 2023

Introduction: Bevacizumab is a monoclonal antibody directed against the human isoform of vascular endothelial growth factor A (VEGF-A) and inhibits angiogenesis. Case: Female patient, 54-year-old, with a history of intestinal adenocarcinoma associated with peritoneal carcinomatosis being treated with bevacizumab. The patient started to present a deviation of the labial rhyme to the right, which showed the presence of left facial paralysis with a central pattern on the neurological physical examination, without other alterations. Magnetic resonance imaging of the brain showed a nodular lesion centered in the subcortical white matter of the right frontoparietal transition, showing T1 hyposignal, T2/FLAIR hypersignal, with areas of pronounced SWAN hyposignal, without significant post-contrast enhancement and a thin halo of diffusion. It has no significant mass effect and measures 1.4 x 2.5 x 2.0 cm. Screening for HIV, toxoplasmosis, cryptococcus and mycobacterial infection was negative. Magnetic resonance imaging of the cervical spine and cerebrospinal fluid analysis were normal. The presence of a demyelinating lesion was observed in the exteriotaxic biopsy, which confirms the hypothesis of a pseudotumoral lesion and rules out the possibility of a metastatic lesion. Over four weeks, there was resolution of neurological signs with radiological improvement in subsequent examinations. There was no evidence of new inflammatory activity, clinically and on MRI over a 2-year period. Conclusion: A definitive causal association between VEGF-A inhibition and central nervous system inflammatory demyelination could not be confirmed in this patient. However, the temporal relationship between institution of bevacizumab therapy and presentation with tumefactive demyelination is significant.
Sex differences in Parkinson’s disease: is there an impact on the national health system? a ten-year analysis
Authors: Dourado Henrique Nascimento , Silveira Maria Alice Amorim da , Pedreira Yasmin Mendonça , Santana Joanna Sousa da Fonseca , Aragão Gabriel Vianna Pereira
Published: July 2023

Introduction: Parkinson’s disease (PD) is the second most prevalent neurodegenerative disease worldwide. National data on its incidence and impact on public health are scarce. Moreover, there are marked differences in sex-related factors, with males exhibiting a higher risk of both developing the disease and experiencing mortality. Objectives: To compare hospitalizations, deaths, and associated costs related to PD between sexes from 2010 to 2020. Methods: This is a descriptive epidemiological study. Data was collected from the Brazilian National Health System’s (DATASUS) database, describing PD cases (CID-10) between 2010 and 2020. As this is a public domain database, there was no need for ethics committee approval. Results: The total number of hospitalizations for PD in Brazil during the studied period (2010–2020) was estimated at 9,993, with 57.4% being male patients. The year with the highest number of hospitalizations was 2016 (1,154 cases), which contrasts with 2020, where only 58.6% of this amount was reported, potentially indicating an impact of the coronavirus pandemic. Regarding mortality, the data show a total of 38,898 deaths associated with PD during the studied period, with 55% being male patients. Although 2010 had the lowest number of reported deaths, the value has increased over the years. In relation to the values of hospital services for PD provided by the National Health Service (SUS) in this time interval, a total of R$27,386,399.29 was spent, with 62.6% of the funding allocated to the treatment of male patients. Conclusion: Between 2010 and 2020, hospitalization, mortality, and public hospital service expenditure associated with Parkinson’s disease were predominantly higher for male patients compared to their female counterparts. These results are consistent with the current literature.
Gut-microbiome-brain-axis: the crosstalk between the vagus nerve, alpha-synuclein and the brain in Parkinson’s disease
Authors: Silva Alexandre Almeida da , Furtado Lucas Cruz , Santos Júlio César Claudino dos
Published: July 2023

Introduction: The vagus nerve, the main component of the parasympathetic nervous system, is involved in the regulation of immune response, digestion, heart rate, and control of mood. It can detect microbiota metabolites through its afferents, transferring this gut information to the central nervous system. Preclinical and clinical studies have shown the important role played by the gut microbiome and gut-related factors in disease development and progression, as well as treatment responses. Objectives: To describe and discuss the close link between the microbiome, the gut and the brain in Parkinson’s disease. Methods: This is a critical review of the literature on the microbiome, gut, and brain in Parkinson’s disease. Results: The gut microbiota has been demonstrated to be a pivotal contributor to the promotion of health. Emerging data has indicated that, up to 20 years before the onset of motor symptoms, an alteration in the gut microbiome may be present in Parkinson’s disease patients. This dysbiosis of the gut may lead to increased intestinal permeability and inflammation, as well as Lewis body formation, and can also cause neuroinflammation and decreased neurotransmitter production in the central nervous system. Conclusion: More studies are needed to better understand the underlying biology and how this axis can be modulated for the patient’s benefit.
Real World Safety and exploratory efficacy of gene therapy for patients with 5q-Spinal Muscular Atrophy in a Brazilian cohort
Authors: Mendonça Rodrigo Holanda , Ortega Adriana Banzatto , Matsui Jr Ciro , Linden Vanessa Van Der , Kerstenetzky Marcelo , Grossklauss Luis Fernando , Lucas Elizabeth Lemos , Polido Graziela Jorge , Zanoteli Edmar
Published: July 2023

Introduction: Spinal muscular atrophy (SMA) is a motor neuron disease associated with progressive muscle weakness, ventilatory failure, and reduced survival. Onasemnogene abeparvoves is the first gene replacement therapy (GT) approved to treat this condition. Methods: Observational retrospective study to assess adverse events and efficacy of gene therapy in types 1 and 2 SMA patients through motor milestones and functional motor scales. Results: Forty-one patients with SMA (24 females, 58.5%) were included, including 33 (80.1%) SMA type 1, seven (17.1%) type 2, and one pre-symptomatic. The mean age at GT dosing was 18 (±6.4) months. Thirty-six patients (87.8%) were under previous treatment with nusinersen, and 10 (24.4%) continued nusinersen after GT dosing. Mean CHOP-INTEND increased 13 points after 6 months and 22 points after 12 months of GT (P < 0.001). CHOP-INTEND increase at six months did not differ between groups according to nusinersen maintenance after GT (P = 0.949). Among SMA type 1 patients, 14 (46.6%) reached the ability to sit alone, and three (10%) stood with support. Liver transaminases elevation at least two times higher than the upper limit of normal value occurred in 29 (70.7%) patients. Thrombocytopenia occurred in 13 (31.7%) patients, and one case presented thrombotic microangiopathy. Older age (> two years) was associated with more prolonged use of corticosteroids (P = 0.021). Conclusion: GT is effective in SMA patients, and combined nusinersen after GT does not present additional gain in motor function. Close monitoring of adverse events is necessary, and older age is associated with prolonged corticosteroid use.