bluuebunny/crossref_metadata_2025 huggingface dataset:
مشكلة الإسقاط وضبط أنظمة الإحداثيات المرتبطة بالخرائط الطبوغرافية والمرئيات الفضائية - دراسة كارتوغرافية – لوحتي البيضاء - بنغازي أنموذجا
Authors: رمضان علي سعد عادل
Published: June 2024

تكمن أهمية موضوع الدراسة (مشكلات مطابقة المرئيات الفضائية مع الخرائط الطبوغرافية) في إجراء عمليات تطابق بين الخرائط الطبوغرافية المعدة وفق نظام كلارك 1880 والخرائط المعدة من الصور والبيانات الفضائية وفق نظام WGS84، ومحاولة الكشف عن طرق في تحديد المواقع للظواهر الجغرافية بين النظامين، حيث ان القيام بإجراء الجانب التطبيقي لنتائج التطابق يفيد في الحصول على أدق المواقع الممكنة لمعطيات السطح الأرضي ، وكذلك يفيد في البحث والاستقصاء عن أسباب عدم التطابق والفروقات الناتجة مع بيان نوع هذه الفروقات والتأثيرات المحتملة سواء للمسافات بين الظواهر أو لاختلافات مواقع خطوط الطول والعرض بين الخرائط الطبوغرافية والمرئيات الفضائية .
 كذلك  اعتمدت هذه الدراسة على نظم المعلومات الجغرافية (GIS) بوصفها وسيلة مهمة تعمل على ترتيب المعلومات وتصنيفها حسب الأهمية والحاجة وتطابقها مع مواقعها الحقيقية، وتتأكد أهمية نظم المعلومات الجغرافية من خلال وجود أنظمة وبرامج تقوم بإجراء عمليات تطابق البيانات لمصادر متعددة مثل الخرائط الطبوغرافية وبمقايس مختلفة والخرائط الكادسترالية والخرائط الموضوعية المعدة من الصور الجوية والبيانات الفضائية فضلا عن الخرائط المعدة والمشتقة من المرئيات الفضائية .
السياسة الخارجية الليبية - دراسة في إدارة السياسية الخارجية (1951-2011م)
Authors: الدين سعيد خطاب د. ولاء , مفتاح دخيل أ. عماد
Published: June 2024

تهدف هذه الدراسة إلى البحث في أسباب فشل السياسة الخارجية الليبية من خلال النظر إلى إدارة السياسة الخارجية الليبية في حقبتين تاريخيتين مختلفتين، امتدت الأولي فيهما لمدة ثمانية عشر عاماً وأما الحقبة الثانية التي تليها فقد امتدت لأكثر من أربعين عاماً، وأوضحت الدراسة كيفية إدارة كلا النظامين (النظام الملكي ونظام ما بعد المملكة) للسياسة الخارجية الليبية ومدى اختلافها في طريقة التعامل مع جهاز صناعة السياسة الخارجية للدولة وعوامل وأسباب فشل السياسة الخارجية الليبية لكلا الحقبتين.
PECULIARITIES OF EMOTIONAL INTELLIGENCE OF ADOLESCENTS PRONE TO VICTIM BEHAVIOR
Authors:   Vladimir State University, Bobchenko Tatyana G.
Published: June 2024

The paper examines the features of emotional intelligence characteristic of adolescents prone to victim behavior. Theoretical analysis of primary sources and the results of the author’s empirical research serves as the foundation for research. The research methods used in the paper include theoretical methods (analysis, generalization of primary sources), collection of empirical data (testing), processing of results (mathematical statistics). Conclusions are drawn about the differences in the emotional intelligence of adolescents: 1) who are not prone to victim behavior, who are prone to it and who have unrealized and realized victimization, 2) who are prone to various types of victim behavior.
THE DAILY WORK LIFE OF WOMEN IN STALINGRAD/VOLGOGRAD IN 1950s-1960s AS SEEN IN AUTO-DOCUMENTARY SOURCES
Authors:   Volgograd State University, Bogdashina Irina V.
Published: June 2024

This paper studies the daily work life of urban women in Stalingrad/Volgograd in the 1950s-1960s, which at the time was the largest industrial region on the Lower Volga. What makes the study relevant is the use of women’s autodocumentary sources (diaries and oral memoirs), which reveal the sensual and emotional components of everyday life. The paper aims to identify the main features of women’s daily work life and to find out the level of women’s labor protection at enterprises in a nonmetropolitan area. The study concludes that the low level of protection of women’s labor, low wages burdened by taxes, and difficult communal and living conditions forced many women workers to adapt to the realities of life in the city being reborn after the war.
Estrategias de Enseñanza – Aprendizaje para Fomentar el Pensamiento Crítico en la Educación Secundaria
Authors: Ibarvo Arias Jeremias Alfredo , Changoluisa Gavilanes Ana Mercedes , Quila Rizzo Jenny Beatriz
Published: June 2024

Este estudio investigó la efectividad de las estrategias de enseñanza-aprendizaje en el fomento del pensamiento crítico en estudiantes de educación secundaria. Se empleó un diseño de investigación mixto, que combinó un enfoque cuasiexperimental con una exploración cualitativa. Los resultados revelaron diferencias significativas entre el grupo experimental y el grupo control en las habilidades y disposiciones de pensamiento crítico, con tamaños del efecto de moderados a grandes. Los datos cualitativos proporcionaron una comprensión más profunda de los cambios observados, destacando mejoras en la capacidad de los estudiantes para cuestionar supuestos, considerar múltiples perspectivas y respaldar sus opiniones con evidencias. Se identificaron estrategias efectivas, como el aprendizaje basado en problemas, los debates en clase y el análisis de casos. Se proponen recomendaciones para la implementación de estrategias que fomenten el pensamiento crítico, incluyendo la incorporación de estrategias desafiantes, la creación de ambientes de aprendizaje reflexivos, la capacitación y apoyo a los docentes, la integración del pensamiento crítico en todas las áreas curriculares y la evaluación y reflexión sobre la efectividad de las estrategias. Este estudio destaca la importancia del pensamiento crítico en la educación secundaria y proporciona orientaciones para su desarrollo.
Aplicación de las Políticas Educativas en el Área de la Educación Física con Enfoque en Baloncesto para los Estudiantes de Décimo Grado de Educación Básica, Unidad Educativa Eugenio Espejo
Authors: Aguilar Parra Jeanelly Cecilia , Reasco Garzón Byron Carlos , Tapia Coronel Rosa Aracely , Mayorga Sánchez Heidy Tanya , Vargas Calle Alvaro Daniel , Castañeda Junco Rina Rosalinda
Published: June 2024

La investigación propone abordar de manera integral la implementación de políticas educativas en el área de la educación física, específicamente centrada en el baloncesto, dirigida a estudiantes de décimo grado en la unidad educativa "Eugenio Espejo". En vista de los cambios de la sociedad y teniendo en cuenta que los colegios son los responsables de solucionar los problemas sociales, en este contexto, el objetivo es equipar a los docentes con conocimientos sobre políticas educativas aplicadas en el ámbito de la educación física y que les permita enseñar de forma innovadora a los estudiantes, los mismos que deben de desarrollar habilidades científicas, ser analíticos, críticos y encaminados hacia una cultura investigativa. El enfoque metodológico combina tanto métodos teóricos como empíricos, respaldados por el análisis estadístico. La investigación adopta un enfoque cualitativo y cuantitativo, se realizó encuestas a los docentes y padres de los estudiantes, además de emplear técnicas como la observación y encuestas para obtener información favorable en el campo de las políticas educativas. Este estudio tiene como fin enfocarse en el baloncesto como el medio para la implementación de estas políticas, se espera promover la actividad física entre los estudiantes, como también fomentar valores como el trabajo en equipo, la disciplina y el liderazgo. Los resultados esperados son el lograr proporcionar información relevante que pueda informar la formulación y ejecución de políticas educativas efectivas en el ámbito de la educación física, contribuyendo así al desarrollo integral de los estudiantes y a la mejora continua del sistema educativo en la unidad educativa "Eugenio Espejo".
Sobrecarga del Cuidador Informal en paciente con Enfermedades Crónicas, en un Prestador Primario de Salud, Montería - Córdoba, 2023
Authors: Romero Ramos Julio Cesar , Hernández Bedoya Wendy Johana , Ramírez Hernández Cristian Andrés
Published: June 2024

Introducción:  Durante los últimos años con el progreso de la sociedad en todos los ámbitos, se ha presentado un aumento de la esperanza de vida y esto se ha acompañado de un cambio en las principales causas de muerte y un aumento de la prevalencia de ciertas patologías (enfermedades crónicas y discapacidades físicas y/o psíquicas), que condicionan cierto grado de dependencia, siendo los adultos mayores el grupo de la población más afectada. Objetivos: Identificar la sobrecarga del cuidador informal en paciente con enfermedades crónicas en un prestador primario de salud, Montería - Córdoba, 2023. Metodología: Estudio cuantitativo descriptivo de corte trasversal. Conto con 120 participantes, correspondientes a la muestra significativa de la población objeto de estudio. Previo consentimiento informado, se identificaron las características sociodemográficas y la sobrecarga del cuidador informal de pacientes con enfermedades crónicas. “Escala de sobrecarga del cuidador de Zarit (Caregiver Burde Interview)”. El análisis estadístico descriptivo permitió representar los datos en frecuencias y porcentajes. Resultados: Participaron 120 cuidadores informales: 77% mujeres y 23% hombres. El 69% era de áreas urbanas, el 31% de zonas rurales. Educación bachillerato 48.2% o técnica/superior (32.5%). Estado civil: solteros 36.6%, casados 31.8%, unión libre 26.6%. Amas de casa 42.5%, trabajadores independientes 27.5%, empleados 22.5%. Estrato I (80%), estrato II 20%. Cuidares hijos (58.3%) Esposo / a 15%. Horas al cuidado de 6-12 horas 52.5%. de 12 – 18 horas 25.8%. a nivel global de la sobrecarga del cuidador informal, es ausencia de sobrecarga con el 66%, seguido sobrecarga ligera con el 19%, y un 15% sobrecarga intensa. Conclusión: Los resultados permitieron cumplir los objetivos de estudio e identificar una correlación positiva entre las competencias del cuidar y la sobrecarga del cuidador informal, que se puede interpretar “a mayores competencias del cuidar menor el nivel de sobrecarga”. Estos hallazgos evidencian que el cuidador informal y prestador primario de salud tiene diversas competencias, además habilidades para ejercer de forma óptima sus roles de cuidadores y prestadores de servicios de salud y por ende tener la capacidad de afrontar situaciones de sobrecarga. La dependencia funcional del paciente crónico en su cuidador se estableció mediante el número de horas que emplea el cuidador informal a su cuidado donde existe relación una dependencia funcional del 79%.
Yorgos Lanthimos y el Subtexto Detrás de lo Absurdo: Una Narrativa Alterna en Poor Things [Pobres Criaturas]
Authors: Acosta Briceño Richard Joel
Published: June 2024

El cineasta griego Yorgos Lanthimos ha cosechado en su filmografía una serie de filmes auténticos que tienen su estilo propio. Estilo en donde predomina lo absurdo debido a los elementos fantasiosos y bizarros que incluye al momento de contar una historia. Además de crear imágenes y sonidos que generan sensaciones extrañas en sus espectadores, Lanthimos también utiliza estos elementos bizarros como elementos narrativos que en conjunto con el resto de elementos fílmicos como la fotografía, vestuario, actuaciones y la misma dirección del cineasta, ayudan a crear un subtexto a la historia principal que busca contar. Poor Things (Lanthimos, 2023) [Pobres Criaturas], no es una excepción. Y es que la historia que a priori parece una fantasía, en realidad tiene un trasfondo mucho más humano, puesto que el director busca narrar los aspectos más importantes del desarrollo interno de una persona, es decir la experiencia humana. El objetivo de este artículo es identificar y analizar este posible subtexto del filme. Para ello, se tomará en cuenta las escenas más relevantes del filme y los elementos ya mencionados, pero sobre todo se analizará a fondo el personaje principal de la historia, al igual que los intertítulos que dividen al filme en capítulos. De esta manera descubriremos si existe una narrativa alterna a la historia central de Lanthimos.
Epidemiología y Factores de Riesgo en Trombosis Pediátrica: Una Revisión de Literatura
Authors: Ruiz Rodríguez Adriana , Mateus Vargas Ana Lucía
Published: June 2024

Entre el 2% y 4% de los infantes fallecen a causa de eventos trombóticos, los cuales han sido históricamente poco comunes en niños debido a factores fisiológicos como la baja concentración de trombina. No obstante, en los últimos años estos eventos han experimentado un aumento hasta diez veces en Estados Unidos. Tanto factores genéticos como adquiridos contribuyen a la trombosis, siendo estos últimos objeto de extenso estudio. Se ha observado que el Cateterismo venoso Central (CVC), los neonatos pre termino, entre otros, junto con infecciones como las provocadas por el SARS-CoV-2, son factores adquiridos comunes. Este artículo resume las causas más frecuentes de trombosis adquiridas en población pediátrica mediante una revisión de informes de casos lo que permiten actualizar el conocimiento en aspectos como la fisiopatología, epidemiología, síntomas, diagnóstico y tratamiento. El principal desafío para la comunidad médica radica en reducir los factores de riesgo, y ampliar los estudios en población pediátrica, dado que parte de los protocolos de diagnóstico, seguimiento y tratamiento se basan en estudios realizados en adultos.
Implementation of Mortgage Rights on the Position of Creditors of Second Mortgage Holders in the Application for Auction Submission
Authors: Rianto Fera Puspita , Suriaatmadja Toto Tohir , Jamilah Lina
Published: June 2024

The binding of credit collateral with mortgage rights can be bound by several creditors with more than one mortgage. If the debtor is in default, only the creditor holding the first rank of mortgage rights can submit the auction, as stated in Law Number 4 of 1996 concerning Mortgage Rights. At the time of the debtor's default, the binding of the first-ranked mortgage has been released by the creditor of the first mortgage holder, the second mortgage holder applies for a mortgage auction and is rejected based on the law. The purpose of this research is to find regulations that provide justice to creditors of second lien holders. Implementation based on the principle of justice to the position of the creditor of the second lien holder in the application for submission of the auction. The research method used in this research uses a normative juridical approach, descriptive analysis and prescriptive analysis specifications with secondary and primary data types, data collection through interviews and qualitative juridical analysis methods, comparative heurmeneutic data that interpret and understand the intent of the regulatory text. The results of this study, as well as updates to previous research, the application of the Mortgage Rights regulation has not been based on the principle of justice, based on the value of justice, it should be that if the debtor is in default, the holder of the mortgage right has the right to sell the object of the mortgage right on its own power through a public auction with the first mortgage right holder having the first right to take repayment of its debt from the proceeds of the sale.
The science and art of biostatistics: a comprehensive overview
Authors: Mishra Akanksha , Khan Mohd. Maruf
Published: June 2024

Biostatistics is the area that involves the application of statistical methods to biological and health-related research and draw out valid conclusion from the obtained data. Statistics are essential to clinical trials and the drug development process, from trial design to protocol preparation. Providing a basic awareness of statistical concerns can help maintain the credibility of a clinical trial. Biostatistics is used at every stage of clinical research, including trial design, protocol development, data tracking and management, data processing, and trial reporting. This article deals with bringing in frame the basic biostatistical concepts that are significant and convenient in analyzing various types of data observations that includes the types of data, measure of central tendency, measure of dispersion, parametric and non-parametric test. Other parameters, such as the normal distribution, sample size computation, significance level, null and alternate hypothesis, and statistical significance test, are thoroughly discussed with appropriate illustrations. The review also mentions the software applications and websites helpful for statistical computations.
E-learning eficaz: o papel do gestor educacional
Authors: Rodrigues Cícero Alexandro Diniz , Belém Breno de Campos , Malta Daniela Paula de Lima Nunes , Melo Júnior Hermócrates Gomes , Souza Maura Aparecida de , Souza Maura Aparecida de , Andrade Filho Marcos Antonio Soares de
Published: June 2024

A pesquisa investigou o papel do gestor educacional no ambiente de e-learning, abordando suas responsabilidades e os desafios enfrentados na implementação e gestão dessas plataformas. O problema identificado foi a falta de compreensão clara e sistematizada sobre as responsabilidades dos gestores educacionais no contexto do e-learning. O objetivo geral foi analisar essas responsabilidades e desafios. O desenvolvimento do estudo baseou-se em uma revisão de literatura, explorando as características dos ambientes de e-learning e as funções dos gestores educacionais. Foram discutidas a integração de tecnologia e pedagogia e a importância da inclusão digital. Nas considerações finais, o estudo destacou que os gestores educacionais desempenham um papel fundamental na administração de ambientes de e-learning, sendo responsáveis pela integração tecnológica com estratégias pedagógicas e pela garantia de um ambiente de aprendizagem eficaz e inclusivo. Concluiu-se que há a necessidade de estudos adicionais para complementar e expandir o entendimento sobre o papel dos gestores educacionais no e-learning.
Automação da criação de planos de aula com inteligência artificial
Authors: Damasceno Maria das Graças de Aguiar , Oliveira Antonio Nonato de , Malta Daniela Paula de Lima Nunes , Pereira Marcela Gomes , Buge Magno Antonio Flegler , Cometti Rodrigo dos Santos
Published: June 2024

Este estudo investigou como a Inteligência Artificial (IA) poderia ser uma aliada no desenvolvimento de recursos educacionais, focando na automação de planos de aula. O problema central abordado foi a eficácia da IA na criação de recursos educacionais sem comprometer a qualidade do ensino e a autonomia dos professores. O objetivo geral foi analisar a aplicação da IA para auxiliar educadores na elaboração de planos de aula, considerando percepções, desafios éticos e práticos. A metodologia utilizada foi uma revisão de literatura, que permitiu a análise de diversas pesquisas recentes sobre o uso de IA na educação. Durante o desenvolvimento, foram discutidos os principais benefícios da IA, como a personalização do ensino e a redução da carga administrativa dos professores. Também foram abordados desafios como a proteção de dados dos alunos e a necessidade de infraestrutura tecnológica adequada. Nas considerações finais, concluiu-se que a IA tem potencial para transformar os processos de ensino e aprendizagem, tornando-os personalizados e eficientes. No entanto, para que esses benefícios sejam realizados, é necessário enfrentar desafios éticos e práticos. A pesquisa destacou a importância de investimentos contínuos em tecnologia e capacitação dos professores, além de sugerir a necessidade de estudos futuros para explorar os impactos da IA em diferentes contextos educacionais.
A síndrome respiratória aguda grave (SRAG) e a resposta metabólica sistêmica (SIM-P) como manifestações clínicas atípicas do SARS-CoV-2 em pacientes pediátricos
Authors: Tabachi Jessie Marcelle Kelis , Barbosa Celio de Barros
Published: June 2024

A pandemia de SARS-CoV-2 foi responsável por mudanças relevantes na saúde global. A partir desse cenário, observou-se o surgimento de manifestações clínicas atípicas em pacientes pediátricos, principalmente, respostas fisiológicas sistêmicas. Em decorrência disso, tornou-se essencial discutir essas complicações do SARS-CoV-2 em crianças, focando em padrões de apresentação, fatores de risco e desfechos clínico. O trabalho buscou caracterizar as manifestações clínicas atípicas do SARS-CoV-2 em pacientes pediátricos, identificando padrões de apresentação e desfechos clínicos por meio de uma revisão literária qualitativa utilizando bases de dados como Google Acadêmico, SciELO, LILACS e BVS entre 2020 e 2023. Dessa forma, constatou-se que as crianças geralmente apresentam quadros leves ou assintomáticos de COVID-19, com manifestações atípicas, como a Síndrome Inflamatória Multissistêmica (SIM-P) e a Síndrome Respiratória Aguda Grave (SRAG). A SIM-P está relacionada com uma inflamação multissistêmica, enquanto a SRAG traz complicações respiratórias severas. Além disso, condições médicas subjacentes e contextos socioeconômicos desfavoráveis aumentam a gravidade da infecção. O estudo fortaleceu a compreensão da fisiopatologia e manejo clínico da infecção em crianças, destacando a necessidade de mais pesquisas sobre complicações pediátricas do COVID-19, principalmente a respeito da SIM-P e da SRAG.
MATLAB Based Angle Optimization Study for Solar Panels in Bursa
Authors: Sırdaş Melda , Kaynaklı Ömer
Published: June 2024

The use of solar energy provides significant opportunities for high levels of clean energy production, particularly in southern regions of our country, given the high energy potential and long periods of sunshine. In recent years, with the increasing focus on sustainability efforts, the utilization of solar energy in our country has been steadily increasing. This study aims to examine the most suitable solar panel angles for the city center of Bursa and Uludag region, with a focus on determining the optimum panel angles on a monthly, seasonal, and yearly basis. The calculation method involved mathematical simulations of panel angles for both regions using MATLAB. Angle values were determined for each degree in the 0-90 degree range for 365 days, based on maximum radiation. The effects of altitude and snowy surface reflection were considered in determining the optimum panel angles. According to the obtained results, the difference between the optimum panel angles for the two regions is 5 degrees annually, it increases to 12 degrees in February. The yearly optimum panel angle is for 34 degrees for the city center, and 39 degrees for Uludag. It was observed that the effect of altitude and snowy surface reflection in Uludag region results in higher panel efficiency and generated electrical energy compared to the city center. Angle values are higher in winter and lower in summer. Although the optimum angle values differ between the two regions during spring and autumn, the yearly total radiation values are the same due to seasonal gains. When considering the seasonal optimum angles for yearly use, the highest total radiation is achieved with the spring and autumn panel angles, while the lowest value is observed with the adjusted panel angle for the summer season. Considering the increase in efficiency based on monthly and yearly optimum angles, it is recommended to adjust the tilt angle periodically to improve the panel efficiency.
The Era of Robotic Process Automation
Authors: Al Thinyan Khalid , Al Shehri Abdullah , Ghawji Haitham , Aramco Saudi
Published: June 2024

Robotic Process Automation (RPA) is a technology that utilizes programmed machines, known as robots, to automate repetitive and tedious tasks performed by humans. By identifying essential modules for a specific task and programming them into a robot, RPA enables the robot to accomplish the task efficiently. This technology offers numerous advantages, including increased productivity, efficiency, performance, and the liberation of human resources for high-value activities. RPA makes tasks more manageable and changes business operations, bringing in a new age of technology. This article offers a thorough overview of Robotic Process Automation (RPA). It explores its rich history, uncovers the numerous advantages and drawbacks, highlights various methodologies and recommended approaches, and discovers cutting-edge advancements in RPA.
The number of Estonian black fungus gnats (Diptera, Sciaridae) doubled: the first records of 64 species
Authors: Gorban Ina , Heller Kai , Kurina Olavi
Published: June 2024

Adult sciarid flies are small to medium-sized, delicate insects, typically black in colour and belonging to the superfamily Sciaroidea within the order Diptera. They exhibit a uniform appearance. Distinguishing them from other families of Sciaroidea is primarily achieved through their typical wing venation. Sciaridae are common in both natural and semi-natural ecosystems, where they play a significant role in decomposition during their larval stage. Prior to the current study, only one specific research project had been conducted on Sciaridae in Estonia. The number of sciarid species identified in Estonia was set at 67.

This research, conducted in north-eastern Estonia during 2015 and 2016, presents a comprehensive overview of Sciaridae diversity, shedding light on previously understudied aspects of Estonia's biodiversity. A total of 1038 specimens were identified, representing 91 species, amongst which 64 were previously unknown to Estonia. Notably, Corynoptera winnertzi (Mohrig, 1993) emerged as the most abundant species, followed by Corynoptera irmgardis (Lengersdorf, 1930), Corynoptera crassistylata (Frey, 1948) and Bradysia trivittata (Staeger, 1840). The genus Corynoptera Winnertz, 1867 exhibited the highest diversity, consistent with findings from broader European studies. This study underscores the importance of ongoing surveys for better understanding the distribution and composition of Sciaridae species in Estonia, emphasising the need for further research to delve into the intricate ecology and biology of these insects.
Moser-Trudinger inequalities on 2-dimensional Hadamard manifolds
Authors: Morpurgo Carlo , Qin Liuyu
Published: June 2024

We derive two types of sharp Moser-Trudinger inequalities on complete, simply connected, two-dimensional Riemannian manifolds whose sectional curvatures $ K $ satisfy the bounds $ -b^2\le K\le -a^2 < 0 $.
Hyperparameter optimization: Classics, acceleration, online, multi-objective, and tools
Authors: Tan Jia Mian , Liao Haoran , Liu Wei , Fan Changjun , Huang Jincai , Liu Zhong , Yan Junchi
Published: June 2024

Hyperparameter optimization (HPO) has been well-developed and evolved into a well-established research topic over the decades. With the success and wide application of deep learning, HPO has garnered increased attention, particularly within the realm of machine learning model training and inference. The primary objective is to mitigate the challenges associated with manual hyperparameter tuning, which can be ad-hoc, reliant on human expertise, and consequently hinders reproducibility while inflating deployment costs. Recognizing the growing significance of HPO, this paper surveyed classical HPO methods, approaches for accelerating the optimization process, HPO in an online setting (dynamic algorithm configuration, DAC), and when there is more than one objective to optimize (multi-objective HPO). Acceleration strategies were categorized into multi-fidelity, bandit-based, and early stopping; DAC algorithms encompassed gradient-based, population-based, and reinforcement learning-based methods; multi-objective HPO can be approached via scalarization, metaheuristics, and model-based algorithms tailored for multi-objective situation. A tabulated overview of popular frameworks and tools for HPO was provided, catering to the interests of practitioners.
Effects of melatonin on the management of multiple sclerosis: A scoping review on animal studies
Authors: Bandehagh Heliya , Gozalpour Farnaz , Mousavi Ali , Ghavshough Mahdi Hemmati
Published: June 2024

Background

Multiple sclerosis (MS), is a debilitating neurological disease that currently has various treatments, like disease-modifying therapies, monoclonal antibodies, corticosteroids, and hormonal derivatives. Melatonin has several actions, like regulating circadian rhythms, which are usually used for insomnia. This scoping review aimed to explore the efficacy of melatonin, both as a standalone treatment and in conjunction with other drugs, in the management of MS in animal models.

Methods

We searched PubMed, Web of Science, EMBASE, and Google Scholar using (“melatonin” OR “melatonin receptor”) AND (“multiple sclerosis”) AND (“animal”). Animal studies that evaluated the effects of melatonin on the development, progression, and outcomes of MS were included. Human studies and other types of studies like case reports were excluded. We used narrative synthesis for reporting the results.

Results

Overall, 21 studies were included, conducted on mice (n = 15) and rats (n = 6). Mostly, studies reported that melatonin led to normal circadian rhythms in animals. Melatonin in doses of both 50 and 100 mg/kg were useful in nociception latency. Melatonin in combination with other drugs like H-89, diisopropylamine dichloroacetate, gibberellins, and IFN-1β improved outcomes, while there was not improved cognition in combination with mesenchymal stem cells. In some tests, male subjects showed significantly better responses. There were controversial results regarding the effects of melatonin on cytokines, but overall, it led to a reduction in proinflammatory cytokines.

Conclusions

Melatonin overall demonstrated favorable outcomes regarding oxidative stress, anti-inflammation, and cytokine levels across various doses. It is recommended conducting systematic reviews and meta-analyses with a larger number of primary studies to provide more comprehensive insights.
Use of plant growth-promoting bacteria to facilitate phytoremediation
Authors: Gamalero Elisa , Glick Bernard R.
Published: June 2024

Here, phytoremediation studies of toxic metal and organic compounds using plants augmented with plant growth-promoting bacteria, published in the past few years, were summarized and reviewed. These studies complemented and extended the many earlier studies in this area of research. The studies summarized here employed a wide range of non-agricultural plants including various grasses indigenous to regions of the world. The plant growth-promoting bacteria used a range of different known mechanisms to promote plant growth in the presence of metallic and/or organic toxicants and thereby improve the phytoremediation ability of most plants. Both rhizosphere and endophyte PGPB strains have been found to be effective within various phytoremediation schemes. Consortia consisting of several PGPB were often more effective than individual PGPB in assisting phytoremediation in the presence of metallic and/or organic environmental contaminants.
A three-dimensional surficial geology model of southern Ontario
Authors: Logan C. E. , Russell H. A. J. , Burt A. K. , Burt A. , Mulligan R. P. M. , Sharpe D. R. , Bajc A. F.
Published: June 2024

Afin d'améliorer les connaissances géoscientifiques sur les eaux souterraines dans le sud de l'Ontario, un modèle régional tridimensionnel de la géologie des formations superficielles du sud de l'Ontario a été élaboré dans le cadre d'une collaboration entre la Commission Géologique de l'Ontario et la Commission Géologique du Canada. Couvrant une superficie d'environ 66 870 kilomètres carrés, le modèle est une synthèse des modèles géologiques existants, de la cartographie de la géologie de surface et des données de subsurface. Le modèle est une reclassification simplifiée en 9 couches de nombreuses formations sédimentaires superficielles locales cartographiées, dont l'épaisseur dépasse par endroits 200 m et dont le volume total est d'environ 2 455 kilomètres cubes. Le modèle intègre la cartographie de la géologie de surface à l'échelle 1:50 000 avec un modèle numérique d'élévation (MNE) topographique corrigé bathymétriquement de 90 m et 8 modèles 3D locaux existants. Les données archivées sur le sous-sol comprennent 10 237 forages géotechniques et stratigraphiques, 3 312 pics de levés géophysiques, 15 902 sites et sections de cartographie de terrain, 537 puits de surveillance et d'approvisionnement en eau et 282 995 enregistrements de puits d'eau. Correspondant approximativement aux couches aquifères et aquitards régionaux, les couches primaires du modèle sont (de la plus ancienne à la plus jeune) : Le substratum rocheux, l'aquifère de base, les sédiments inférieurs, le till régional, le remplissage de chenaux après le till régional, les sédiments fluvioglaciaires, les boues après le till régional, les sables glaciolacustres et les sédiments récents/organiques. La modélisation a été réalisée à l'aide d'une application de modélisation implicite (LeapFrog®) complétée par une approche de la classification des données basée sur les connaissances d'experts et une procédure de système expert basée sur des règles pour l'interprétation et la validation des données. Un cycle itératif de codage automatisé des données, de construction de modèles intermédiaires et de corrections manuelles des données, d'évaluations d'experts et de révisions a conduit au modèle 3D final. Ce modèle de géologie de surface complète le développement d'une série de modèles géologiques et hydrogéologiques régionaux en 3D pour le sud de l'Ontario.
On the classification of simple amenable $\mathrm{C}^{*}$-algebras with finite decomposition rank, II
Authors: Elliott George A. , Gong Guihua , Lin Huaxin , Niu Zhuang
Published: June 2024

We prove that every unital simple separable

\mathrm{C}^{*}

-algebra

A

with finite decomposition rank which satisfies the UCT has the property that

A\otimes Q

has generalized tracial rank at most one, where

Q

is the universal UHF-algebra. Consequently,

A

is classifiable in the sense of Elliott.
Colorectal cancer and dormant metastases: Put to sleep or destroy?
Authors: Senchukova Marina A
Published: June 2024

After reading the review by An et al “Biological factors driving colorectal cancer metastasis”, which covers the problem of the metastasis of colorectal cancer (CRC), I had a desire to discuss with readers one of the exciting problems associated with dormant metastases. Most deaths from CRCs are caused by metastases, which can be detected both at diagnosis of the primary tumor and several years or even decades after treatment. This is because tumor cells that enter the bloodstream can be destroyed by the immune system, cause metastatic growth, or remain dormant for a long time. Dormant tumor cells may not manifest themselves throughout a person’s life or, after some time and under appropriate conditions, may give rise to the growth of metastases. In this editorial, we will discuss the most important features of dormant metastases and the mechanisms of premetastatic niche formation, as well as factors that contribute to the activation of dormant metastases in CRCs. We will pay special attention to the possible mechanisms involved in the formation of circulating tumor cell complexes and the choice of therapeutic strategies that promote the dormancy or destruction of tumor cells in CRCs.
Predicting the prognosis of hepatic arterial infusion chemotherapy in hepatocellular carcinoma
Authors: Wang Qi-Feng , Li Zong-Wei , Zhou Hai-Feng , Zhu Kun-Zhong , Wang Ya-Jing , Wang Ya-Qin , Zhang Yue-Wei
Published: June 2024

Hepatic artery infusion chemotherapy (HAIC) has good clinical efficacy in the treatment of advanced hepatocellular carcinoma (HCC); however, its efficacy varies. This review summarized the ability of various markers to predict the efficacy of HAIC and provided a reference for clinical applications. As of October 25, 2023, 51 articles have been retrieved based on keyword predictions and HAIC. Sixteen eligible articles were selected for inclusion in this study. Comprehensive literature analysis found that methods used to predict the efficacy of HAIC include serological testing, gene testing, and imaging testing. The above indicators and their combined forms showed excellent predictive effects in retrospective studies. This review summarized the strategies currently used to predict the efficacy of HAIC in middle and advanced HCC, analyzed each marker's ability to predict HAIC efficacy, and provided a reference for the clinical application of the prediction system.
Action of circulating and infiltrating B cells in the immune microenvironment of colorectal cancer by single-cell sequencing analysis
Authors: Zhang Jing-Po , Yan Bing-Zheng , Liu Jie , Wang Wei
Published: June 2024

BACKGROUND

The complexity of the immune microenvironment has an impact on the treatment of colorectal cancer (CRC), one of the most prevalent malignancies worldwide. In this study, multi-omics and single-cell sequencing techniques were used to investigate the mechanism of action of circulating and infiltrating B cells in CRC. By revealing the heterogeneity and functional differences of B cells in cancer immunity, we aim to deepen our understanding of immune regulation and provide a scientific basis for the development of more effective cancer treatment strategies.

AIM

To explore the role of circulating and infiltrating B cell subsets in the immune microenvironment of CRC, explore the potential driving mechanism of B cell development, analyze the interaction between B cells and other immune cells in the immune microenvironment and the functions of communication molecules, and search for possible regulatory pathways to promote the anti-tumor effects of B cells.

METHODS

A total of 69 paracancer (normal), tumor and peripheral blood samples were collected from 23 patients with CRC from The Cancer Genome Atlas database (https://portal.gdc.cancer.gov/ ). After the immune cells were sorted by multicolor flow cytometry, the single cell transcriptome and B cell receptor group library were sequenced using the 10X Genomics platform, and the data were analyzed using bioinformatics tools such as Seurat. The differences in the number and function of B cell infiltration between tumor and normal tissue, the interaction between B cell subsets and T cells and myeloid cell subsets, and the transcription factor regulatory network of B cell subsets were explored and analyzed.

RESULTS

Compared with normal tissue, the infiltrating number of CD20+B cell subsets in tumor tissue increased significantly. Among them, germinal center B cells (GCB) played the most prominent role, with positive clone expansion and heavy chain mutation level increasing, and the trend of differentiation into memory B cells increased. However, the number of plasma cells in the tumor microenvironment decreased significantly, and the plasma cells secreting IgA antibodies decreased most obviously. In addition, compared with the immune microenvironment of normal tissues, GCB cells in tumor tissues became more closely connected with other immune cells such as T cells, and communication molecules that positively regulate immune function were significantly enriched.

CONCLUSION

The role of GCB in CRC tumor microenvironment is greatly enhanced, and its affinity to tumor antigen is enhanced by its significantly increased heavy chain mutation level. Meanwhile, GCB has enhanced its association with immune cells in the microenvironment, which plays a positive anti-tumor effect.
Sm-like 5 knockdown inhibits proliferation and promotes apoptosis of colon cancer cells by upregulating p53, CDKN1A and TNFRSF10B
Authors: Mo Cai-Jing , Deng Xiao-Yuan , Ma Ru-Lan , Zhu Kun , Shi Lei , Li Kang
Published: June 2024

BACKGROUND

The role of Sm-like 5 (LSM5) in colon cancer has not been determined. In this study, we investigated the role of LSM5 in progression of colon cancer and the potential underlying mechanism involved.

AIM

To determine the role of LSM5 in the progression of colon cancer and the potential underlying mechanism involved.

METHODS

The Gene Expression Profiling Interactive Analysis database and the Human Protein Atlas website were used for LSM5 expression analysis and prognosis analysis. Real-time quantitative polymerase chain reaction and Western blotting were utilized to detect the expression of mRNAs and proteins. A lentivirus targeting LSM5 was constructed and transfected into colon cancer cells to silence LSM5 expression. Proliferation and apoptosis assays were also conducted to evaluate the growth of the colon cancer cells. Human GeneChip assay and bioinformatics analysis were performed to identify the potential underlying mechanism of LSM5 in colon cancer.

RESULTS

LSM5 was highly expressed in tumor tissue and colon cancer cells. A high expression level of LSM5 was related to poor prognosis in patients with colon cancer. Knockdown of LSM5 suppressed proliferation and promoted apoptosis in colon cancer cells. Silencing of LSM5 also facilitates the expression of p53, cyclin-dependent kinase inhibitor 1A (CDKN1A) and tumor necrosis factor receptor superfamily 10B (TNFRSF10B). The inhibitory effect of LSM5 knockdown on the growth of colon cancer cells was associated with the upregulation of p53, CDKN1A and TNFRSF10B.

CONCLUSION

LSM5 knockdown inhibited the proliferation and facilitated the apoptosis of colon cancer cells by upregulating p53, CDKN1A and TNFRSF10B.
Ferroptosis regulating lipid peroxidation metabolism in the occurrence and development of gastric cancer
Authors: Wang Lan-Mei , Zhang Wei-Wei , Qiu Ying-Yang , Wang Fang
Published: June 2024

BACKGROUND

Gastric cancer is one of the most common malignant tumors in the world, and its occurrence and development involve complex biological processes. Iron death, as a new cell death mode, has attracted wide attention in recent years. However, the regulatory mechanism of iron death in gastric cancer and its effect on lipid peroxidation metabolism remain unclear.

AIM

To explore the role of iron death in the development of gastric cancer, reveal its relationship with lipid peroxidation, and provide a new theoretical basis for revealing the molecular mechanism of the occurrence and development of gastric cancer.

METHODS

The process of iron death in gastric cancer cells was simulated by cell culture model, and the occurrence of iron death was detected by fluorescence microscopy and flow cytometry. The changes of gene expression related to iron death and lipid peroxidation metabolism were analyzed by high-throughput sequencing technology. In addition, a mouse model of gastric cancer was established, and the role of iron death in vivo was studied by histology and immunohistochemistry, and the level of lipid peroxidation was detected. These methods comprehensively and deeply reveal the regulatory mechanism of iron death on lipid peroxidation metabolism in the occurrence and development of gastric cancer.

RESULTS

Iron death was significantly activated in gastric cancer cells, and at the same time, associated lipid peroxidation levels increased significantly. Through high-throughput sequencing analysis, it was found that iron death regulated the expression of several genes related to lipid metabolism. In vivo experiments demonstrated that increased iron death in gastric cancer mice was accompanied by a significant increase in lipid peroxidation.

CONCLUSION

This study confirmed the important role of iron death in regulating lipid peroxidation metabolism in the occurrence and development of gastric cancer. The activation of iron death significantly increased lipid peroxidation levels, revealing its regulatory mechanism inside the cell.
Correlation analysis of interstitial maturity and prognosis of colorectal cancer: Meta-analysis
Authors: Liu Zhen-Jun , Zhang Xu-Wen , Liu Qi-Qi , Wang Shao-Zhao
Published: June 2024

BACKGROUND

To investigate the relationship between interstitial maturity and prognosis of colorectal cancer.

AIM

To examine the correlation between interstitial maturity and the prognosis of colorectal cancer.

METHODS

The paper database PubMed, EMBASE, Cochranelibrary, Springerlink, CNKI, and Wanfang database were searched until December 2023. "tumor stroma maturity" "desmoplastic stroma reaction" "desmoplastic reaction" "stroma reaction" "degree of stroma reaction "" stroma classification" "stroma density" "colorectal cancer" "colon cancer" "rectal cancer" "prognosis" were searched for the search terms. Two system assessors independently screened the literature quality according to the inclusion exclusion criteria, Quality evaluation and data extraction were performed for the included literatures, and meta-analysis was performed for randomized control trials included at using Review Manager 5.2 software.

RESULTS

Finally, data of 9849 patients with colorectal cancer from 19 cosets in 15 literatures were included, including 4339 patients with mature type (control group), 3048 patients with intermediate type (intermediate group) and 2456 patients with immature type (immature group). The results of meta-analysis showed: Relapse-free survival [hazard ratio (HR) = 2.66, 95% confidence interval (CI): 2.30-3.08; P < 0.00001], disease-free survival (HR = 3.68, 95%CI: 2.33-5.81; P < 0.00001) and overall survival (HR = 1.70, 95%CI: 1.53-1.87; P < 0.00001) were significantly lower than those in mature group (control group); relapse-free survival (HR = 1.36, 95%CI: 1.17-1.59; P < 0.0001) and disease-free survival rate (HR = 1.85, 95%CI: 1.53-2.24; P < 0.0001) was significantly lower than the mature group (control group).

CONCLUSION

There is the correlation between tumor interstitial maturity and survival prognosis of colorectal cancer, and different degrees of tumor interstitial maturity have a certain impact on the quality of life of colorectal cancer patients.
Endoscopic ultrasound-guided pancreatic fluid collection drainage: Where are we?
Authors: Singh Anupam Kumar , Manrai Manish , Kochhar Rakesh
Published: June 2024

Pancreatic fluid collections (PFCs) result from injury to the pancreas from acute or chronic pancreatitis, surgery, or trauma. Management of these collections has evolved over the last 2 decades. The choice of interventions includes percutaneous, endoscopic, minimally invasive surgery, or a combined approach. Endoscopic drainage is the drainage of PFCs by creating an artificial communication between the collection and gastrointestinal lumen that is maintained by placing a stent across the fistulous tract. In this editorial, we endeavored to update the current status of endoscopic ultrasound-guided drainage of PFCs.
Lighting and Marking of Industrial Equipment on Highways
Authors:   OPTC3, Lighting and Sound Committee
Published: June 2024

To provide specifications for lighting and marking of industrial wheeled equipment whenever such equipment is operated or traveling on a highway.
Wyznaczanie radców prawnych o udzielania nieodpłatnej pomocy prawnej w świetle orzecznictwa sądów administracyjnych
Authors: Daniluk Dawid
Published: June 2024

Attorneys-at-law are one of the entities performing public tasks related to providing free legal assistance. This service is provided at various locations throughout Poland. Every year, districts conclude agreements with various bar associations of attorneys-at-law regulating the provision of free legal assistance in a given district’s area. In the jurisprudence of administrative courts, the only issue analysed so far related to appointing attorneys-at-law to provide free legal assistance is the possibility of participation in this procedure exclusively by attorneys-at-law associated with a particular bar association of attorneys-at-law.