bluuebunny/crossref_metadata_2025 huggingface dataset:
Should We Regularly Assess Hemoglobin Levels Following Elective Total Knee Arthroplasty, with the Administration of TXA and Without the Usage Tourniquet? An Observational Study from a Single Center
Authors: Gur Shanny , Akselrad Mor Bracha , Segal David , Fuchs Yuval , Perl Dan , Fainzack Alon , Ohana Nissim , Yaacobi Eyal , Markushevich Michael , Brin Yaron Shraga
Published: November 2024

Background and Objectives: The aim of this study was to test whether there is a necessity for routine postoperative laboratory testing in patients undergoing primary elective unilateral total knee arthroplasty (TKA), with the administration of Tranexamic Acid (TXA) and without the use of tourniquet. Materials and Methods: This observational, retrospective cohort study was conducted at Meir Medical Center. The data were collected in 2018–2022. Patients were collected in a consecutive manner. There were no exclusion criteria for this study. The inclusion criteria were individuals who underwent elective TKA due to end-stage osteoarthritis (OA). We conducted a multivariable logistic regression analysis to determine the factors associated with postoperative hemoglobin (PoOHb) < 9 g/dL and the optimal cutoff to detect those patients postoperatively. Results: A total of 271 patients were included. The mean preoperative hemoglobin (PrOHb) was 13.02 ± 1.42 g/dL, and the mean PoOHb was 11.5 ± 1.34 g/dL. The mean decrease in Hbg levels following surgery was 1.52 ± 0.91 g/dL. In all, 271 patients had a PoOHb level ≥ 9 g/dL or above. A total of 16 patients received packed red blood cells following surgery. Patients with PoOHb < 9 g/dL had a significantly lower PrOHbg. In the current study, all 11 patients who had PoOHb < 9, 10 (90.9%) had PrOHb ≤ 1011.95 55 g/dL, compared to 25 (49.6%) of the 260 patients who had PoOHb ≥ 9. The odds ratio for having PrOHb ≤ 10.9511.55 g/dL if PoOHb < 9 g/dL was 206.6710.4 (95% CI 24.427.164 to 1749.01415.97). A cut-off of 11.2510.25 would have offered a sensitivity of 99% (specificity 93.5%). Conclusions: In conclusion, this study supports using selective post-TKR Hgb monitoring rather than adhering to routine practice. An association between postoperative anemia and the need for blood transfusion was found only when the preoperative baseline hemoglobin threshold was less than 10.95 g/dL.
Characteristic Polyphenols in 15 Varieties of Chinese Jujubes Based on Metabolomics
Authors: Shao Yong , Li Siying , Chen Xuan , Zhang Jiahui , Jianaerbieke Huxitaer , Chen Gang , Wang Xiaodong , Song Jianxin
Published: November 2024

Background: Jujube is a homologous herb of medicine and food, and polyphenols are key in determining the functional effects of jujubes. Methods: In this study, characteristic polyphenols in 15 varieties of Chinese jujubes were investigated based on untargeted metabolomics. Results: The results showed that a total of 79 characteristic polyphenols were identified in the 15 varieties of Chinese jujube, and 55 characteristic polyphenols such as syringetin, spinosin and kaempferol were reported for the first time. Scopoletin (63.94% in LZYZ), pectolinarin (22.63% in HZ) and taxifolin (19.69% in HZ) contributed greatly and presented significant (p < 0.05) differences in the 15 varieties of Chinese jujubes. HZ was characterized by pectolinarin, erianin and wogonoside, while XSHZ, NYDZ and RQHZ, with similar polyphenol profiles, were characterized by (+)-catechin, combretastatin A4 and tectorigenin. JSBZ, HMDZ, TZ, JCJZ and HPZ had similar polyphenol profiles of galangin, isoferulic acid and hydroxysafflor yellow A. Conclusions: Metabolomics is critical in grasping the full polyphenol contents of jujubes, and the differences in the polyphenol profiles and characteristic individual polyphenols of the 15 varieties of Chinese jujubes were well analyzed by principal component analysis (PCA).
Application of Micro/Nanomotors in Environmental Remediation: A Review
Authors: He Tao , Liu Shishuo , Yang Yonghui , Chen Xuebo
Published: November 2024

The advent of self-propelled micro/nanomotors represents a paradigm shift in the field of environmental remediation, offering a significant enhancement in the efficiency of conventional operations through the exploitation of the material phenomenon of active motion. Despite the considerable promise of micro/nanomotors for applications in environmental remediation, there has been a paucity of reviews that have focused on this area. This review identifies the current opportunities and challenges in utilizing micro/nanomotors to enhance contaminant degradation and removal, accelerate bacterial death, or enable dynamic environmental monitoring. It illustrates how mobile reactors or receptors can dramatically increase the speed and efficiency of environmental remediation processes. These studies exemplify the wide range of environmental applications of dynamic micro/nanomotors associated with their continuous motion, force, and function. Finally, the review discusses the challenges of transferring these exciting advances from the experimental scale to larger-scale field applications.
Multimode Miniature Polarization-Sensitive Metamaterial Absorber with Ultra-Wide Bandwidth in the K Band
Authors: Ji Zhonghang , Song Yida , Gao Mandi , Zhang Qiong , Liu Yunqing
Published: November 2024

Metamaterial absorbers have gained widespread applications in fields such as sensing, imaging, and electromagnetic cloaking due to their unique absorption characteristics. This paper presents the design and fabrication of a novel K-band polarization-sensitive metamaterial absorber, which operates in the frequency range of 20.76 to 24.20 GHz for both TE and TM modes, achieving an absorption rate exceeding 90% and a bandwidth of up to 3.44 GHz. The structure of the metamaterial absorber consists of a rectangular aperture metallic patch, two metallic rings, and two metallic strips, with a metallic patch structure on the back. Both metallic patches are printed on a 1.575 mm-thick FR-4 substrate. In the TE mode, the performance shows diagonal symmetry, with a minimum absorption bandwidth of 1.4 GHz at 45° and a maximum of 3.44 GHz at 0°. The absorption rate exceeds 90% across various polarization angles. In terms of conventional modes, both the TE and TM modes can achieve ultra-wideband absorption. For specific scenarios requiring single-frequency or multi-frequency absorption, the desired functionality can be realized by varying the incident angle. These exceptional characteristics confer strong applicability for high-bandwidth electromagnetic wave absorption and specific frequency point absorption, indicating significant potential and practical value in the field of wireless communication.
Recent Advancements in Co3O4-Based Composites for Enhanced Electrocatalytic Water Splitting
Authors: Wagh Komal S. , Mane Sagar M. , Teli Aviraj M. , Shin Jae Cheol , Lee Jaewoong
Published: November 2024

The pursuit of efficient and economical catalysts for water splitting, a critical step in hydrogen production, has gained momentum with the increasing demand for sustainable energy. Among the various electrocatalysts developed to date, cobalt oxide (Co3O4) has emerged as a promising candidate owing to its availability, stability, and catalytic activity. However, intrinsic limitations, including low catalytic activity and poor electrical conductivity, often hinder its effectiveness in electrocatalytic water splitting. To overcome these challenges, substantial efforts have focused on enhancing the electrocatalytic performance of Co3O4 by synthesizing composites with conductive materials, transition metals, carbon-based nanomaterials, and metal–organic frameworks. This review explores the recent advancements in Co3O4-based composites for the oxygen evolution reaction and the hydrogen evolution reaction, emphasizing strategies such as nanostructuring, doping, hybridization, and surface modification to improve catalytic performance. Additionally, it examines the mechanisms driving the enhanced activity and stability of these composites while also discussing the future potential of Co3O4-based electrocatalysts for large-scale water-splitting applications.
Recent Advancements in 2D Material-Based Memristor Technology Toward Neuromorphic Computing
Authors: Park Sungmin , Naqi Muhammad , Lee Namgyu , Park Suyoung , Hong Seongin , Lee Byeong Hyeon
Published: November 2024

Two-dimensional (2D) layered materials have recently gained significant attention and have been extensively studied for their potential applications in neuromorphic computing, where they are used to mimic the functions of the human brain. Their unique properties, including atomic-level thickness, exceptional mechanical stability, and tunable optical and electrical characteristics, make them highly versatile for a wide range of applications. In this review, we offer a comprehensive analysis of 2D material-based memristors. Furthermore, we examine the ability of 2D material-based memristors to successfully mimic the human brain by referencing their neuromorphic applications.
Microbial Communities in and Around the Siboglinid Tubeworms from the South Yungan East Ridge Cold Seep Offshore Southwestern Taiwan at the Northern South China Sea
Authors: Li Yin , Ye Zhiwei , Lai Mei-Chin , Liu Char-Shine , Paull Charles K. , Lin Saulwood , Lai Shu-Jung , You Yi-Ting , Wu Sue-Yao , Hung Chuan-Chuan , Ding Jiun-Yan , Shih Chao-Jen , Wu Yen-Chi , Zhao Jingjing , Xiao Wangchuan , Wu Chih-Hung , Dong Guowen , Zhang Hangying , Qiu Wanling , Wang Song , Chen Sheng-Chung
Published: November 2024

To date, only a few microbial community studies of cold seeps at the South China Sea (SCS) have been reported. The cold seep dominated by tubeworms was discovered at South Yungan East Ridge (SYER) offshore southwestern Taiwan by miniROV. The tubeworms were identified and proposed as Paraescarpia formosa sp. nov. through morphological and phylogenetic analyses. The endosymbionts in the trunk of P. formosa analyzed by a 16S rRNA gene clone library represented only one phylotype, which belonged to the family Sedimenticolaceae in Gammaproteobacteria. In addition, the archaeal and bacterial communities in the habitat of tubeworm P. formosa were investigated by using high-phylogenetic-resolution full-length 16S rRNA gene amplicon sequencing. The results showed that anerobic methane-oxidizing archaea (ANME)-1b was most abundant and ANME-2ab was minor in a consortia of the anerobic oxidation of methane (AOM). The known sulfate-reducing bacteria (SRB) partners in AOM consortia, such as SEEP-SRB1, -SRB2, and -SRB4, Desulfococcus and Desulfobulbus, occurred in a small population (0–5.7%) at the SYER cold seep, and it was suggested that ANME-1b and ANME-2ab might be coupled with multiple SRB in AOM consortia. Besides AOM consortia, various methanogenic archaea, including Bathyarchaeota (Subgroup-8), Methanocellales, Methanomicrobiales, Methanosarcinales, Methanofastidiosales and Methanomassiliicoccales, were identified, and sulfur-oxidizing bacteria Sulfurovum and Sulfurimonas in phylum Epsilonbacteraeota were dominant. This study revealed the first investigation of microbiota in and around tubeworm P. formosa discovered at the SYER cold seep offshore southwestern Taiwan. We could gain insights into the chemosynthetic communities in the deep sea, especially regarding the cold seep ecosystems at the SCS.
Rapid Immobilisation of Chemical Reactions in Alkali-Activated Materials Using Solely Microwave Irradiation
Authors: Tesovnik Anže , Horvat Barbara
Published: November 2024

Efflorescence, a time-dependent and water-driven phenomenon, is a major concern in alkali-activated materials (AAMs), impacting their practical use and preservation in a time-frozen state for post-characterisation. Although a method for stopping chemical reactions in conventional cements exists, it is time-consuming and not chemical-free. Therefore, this study explored the effects of low-power microwave-induced dehydration on efflorescence, mechanical performance, and structural integrity in AAMs, to create an alternative and more “user-friendly” dehydration method. For this purpose, several mixtures based on secondary raw (slag, fly ash, glass wool, and rock wool) and non-waste (metakaolin) materials were activated with a commercial Na-silicate solution in ratios that promoted or prevented efflorescence. Characterisation techniques, including Fourier-transform infrared spectroscopy and X-ray diffraction, showed that microwave dehydration effectively removed water without altering crystallinity, while mercury intrusion porosimetry and compressive strength tests confirmed increased porosity. In addition to being an efficient, time-saving, and solvent-free manner of stopping the reactions in AAMs, microwave irradiation emerged as an innovative, chemical-free method for evaluating curing finalisation and engineering foams in a stage when all other existing methods fail. However, the artificially provoked efflorescence in aged dehydrated AAMs connected the slipperiness of AAM with the instant extraction of Na, which raised the need for further research into alternative alkali replacements to evaluate the practical use of AAM.
Bis-Iridoids: Occurrence, Chemophenetic Evaluation and Biological Activities—A Review
Authors: Frezza Claudio , Venditti Alessandro , De Vita Daniela , Guiso Marcella , Bianco Armandodoriano
Published: November 2024

In this work, the first review paper about bis-iridoids was presented. In particular, their detailed occurrence, chemophenetic evaluation and biological activities were reported. To the best of our knowledge, two hundred and eighty-eight bis-iridoids have been evidenced so far, bearing different structural features, with the link between two seco-iridoids sub-units as the major one. Different types of base structures have been found, with catalpol, loganin, paederosidic acid, olesoide methyl ester, secoxyloganin and loganetin as the major ones. Even bis-irdioids with non-conventional structures like intra-cyclized and non-alkene six rings have been reported. Some of these compounds have been individuated as chemophenetic markers at different levels, such as cantleyoside, laciniatosides, sylvestrosides, GI-3, GI-5, oleonuezhenide, (Z)-aldosecologanin and centauroside. Only one hundred and fifty-nine bis-iridoids have been tested for their biological effects, including enzymatic, antioxidant, antimicrobial, antitumoral and anti-inflammatory. Sylvestroside I was the compound with the highest number of biological tests, whereas cantleyoside was the compound with the highest number of specific biological tests. Bis-iridoids have not always shown activity, and when active, their effectiveness values have been both higher and lower than the positive controls, if present. All these aspects have been deeply discussed in this paper, which also shows some critical issues and even suggests possible arguments for future research, since there is still a lot unknown about bis-iridoids.
Marizomib Promotes Senescence or Long-Term Apoptosis in Melanoma Cancer Cells
Authors: Piskorz Wiktoria Monika , Krętowski Rafał , Cechowska-Pasko Marzanna
Published: November 2024

Cellular senescence is cell cycle arrest and the inhibition of cell proliferation. New anticancer approaches include the elimination of cancer cells through the induction of senescence followed by senolysis. New prosenescence compounds are still being searched for. Little is known about the ability of proteasome inhibitors to induce senescence in tumor cells, especially in malignant melanoma. The aim of our study was to verify the activity of a natural proteasome inhibitor—marizomib (MZB)—directly after incubation and after its removal to assess its potential to induce senescence or long-term apoptosis in malignant melanoma cell lines (A375 and G361). After 48 h of incubation with MZB, we observed an increased number of SA-β-galactosidase-positive cells, upregulated expression of P21 and P-P53 proteins and an increased number of cells at the subG1 phase (line G361) or at both the subG1 and G2/M phases (line A375). After 96 h from inhibitor removal, the G361 line presented signs of senescence (increased level of SA-β-galactosidase, IL-8, P-P53, G2/M and S phases of cell cycle, decreased lamin B1 and cleaved lamin B1), while the A375 line demonstrated more signs of apoptosis (increased subG1 phase, P-P53, cleaved lamin B1). The gathered findings suggest that MZB resulted in the induction of cellular senescence (line G361) or enhanced apoptosis (line A375) in the melanoma cell lines tested here and could be a promising therapeutic factor in malignant melanoma treatment.
Influence of Hydrogen and Ethanol Addition in Methanogen-Free Mixed Culture Syngas Fermentations in Trickle Bed Reactors
Authors: Quintela Cesar , Alexe Iulian-Gabriel , Nygård Yvonne , Olsson Lisbeth , Skiadas Ioannis V. , Gavala Hariklia N.
Published: November 2024

The use of mixed cultures in gas fermentations could reduce operating costs in the production of liquid chemicals such as alcohols or carboxylic acids. However, directing reducing equivalents towards the desired products presents the challenge of co-existing competing pathways. In this study, two trickle bed reactors were operated at acetogenic and chain elongating conditions to explore the fate of electron equivalents (ethanol, H2, and CO) and test pH oscillations as a strategy to target chain-elongated products. Hereby, the use of a H2-rich syngas increased gas conversion rates and the specificity towards acetic acid (86% of C-mol production, 9.0 g LEBV−1 day−1, with EBV referring to empty bed volume), while preliminary experiments with CO-rich syngas show promising results in increasing the ethanol production necessary to target chain-elongated products. On the other hand, ethanol supplementation hindered the endogenous ethanol production of the acetogenic culture but promoted butanol production (1.0 g LEBV−1 day−1) at high ethanol concentrations (9.6 g L−1) in the fresh media. Finally, pH oscillations improved chain elongation yields but negatively affected acetogenic growth, reducing production rates.
Nanotechnology in Drug Delivery: Anatomy and Molecular Insight into the Self-Assembly of Peptide-Based Hydrogels
Authors: Mashweu Adelaide R. , Azov Vladimir A.
Published: November 2024

The bioavailability, release, and stability of pharmaceuticals under physicochemical conditions is the major cause of drug candidates failing during their clinical trials. Therefore, extensive efforts have been invested in the development of novel drug delivery systems that are able to transport drugs to a desired site and improve bioavailability. Hydrogels, and peptide hydrogels in particular, have been extensively investigated due to their excellent biocompatibility and biodegradability properties. However, peptide hydrogels often have weak mechanical strength, which limits their therapeutic efficacy. Therefore, a number of methods for improving their rheological properties have been established. This review will cover the broad area of drug delivery, focusing on the recent developments in this research field. We will discuss the variety of different types of nanocarrier drug delivery systems and then, more specifically, the significance and perspectives of peptide-based hydrogels. In particular, the interplay of intermolecular forces that govern the self-assembly of peptide hydrogels, progress made in understanding the distinct morphologies of hydrogels, and applications of non-canonical amino acids in hydrogel design will be discussed in more detail.
Iron Porphyrin-Based Composites for Electrocatalytic Oxygen Reduction Reactions
Authors: George Stennard Leetroy , Zhao Linkai , Wang Ziyi , Xue Zhaoli , Zhao Long
Published: November 2024

The oxygen reduction reaction (ORR) is one of the most critical reactions in energy conversion systems, and it facilitates the efficient conversion of chemical energy into electrical energy, which is necessary for modern technology. Developing efficient and cost-effective catalysts for ORRs is crucial for advancing and effectively applying renewable energy technologies such as fuel cells, metal–air batteries, and electrochemical sensors. In recent years, iron porphyrin-based composites have emerged as ideal catalysts for facilitating effective ORRs due to their unique structural characteristics, abundance, advances in synthesis, and excellent catalytic properties, which mimic natural enzymatic systems. However, many articles have focused on reviewing porphyrin-based frameworks or metalloporphyrins in general, necessitating research specifically addressing iron porphyrin. This review discusses iron porphyrin as an effective catalyst in ORRs. It provides a comprehensive knowledge of the application of iron porphyrin-based composites for electrocatalytic ORRs, focusing on their properties, synthesis, structural integration with conductive supports, catalytic mechanism, and efficacy. This review also discusses the challenges of applying iron porphyrin-based composites and provides recommendations to address these challenges.
Law and Order of Colloidal Tectonics: From Molecules to Self-Assembled Colloids
Authors: Leclercq Loïc
Published: November 2024

Since biochemists and biologists have progressed in understanding the mechanisms involved in living organisms, biological systems have become a source of inspiration for chemists. In this context, the concept of colloidal tectonics, describing the spontaneous formation of colloidal particles or supracolloidal structures in which the building blocks are called “tectons”, has emerged. Therefore, a bottom-up edification of tectons towards (supra) colloidal structures is allowed. Each (supra) colloidal system has at least one of the following properties: amphiphilicity, predictability, versatility, commutability, and reversibility. However, for these systems to perform even more interesting functions, it is necessary for tectons to have very precise chemical and physical properties so that new properties emerge in (supra) colloidal systems. In this way, colloidal tectonics enables engineering at the nano- and micrometric level and contributes to the development of smart bioinspired systems with applications in catalysis, drug delivery, etc. In this review, an overview of the concept of colloidal tectonics is illustrated by some biotic systems. The design of abiotic (supra) colloidal systems and their applications in various fields are also addressed (notably Pickering emulsions for catalysis or drug delivery). Finally, theoretical directions for the design of novel self-assembled (supra) colloidal systems are discussed.
Effects of Different Concentrations of AmB on the Unsaturated Phospholipid–Cholesterol Membrane Using the Langmuir Monolayer and Liposome Models
Authors: Wang Juan , Wang Jia , Zheng Mingyue , Li Da
Published: November 2024

Amphotericin B (AmB) causes toxicity to the erythrocyte membrane, leading to hemolysis, which limits the clinically effective dose for AmB intravenous therapy in invasive fungal infections. The molecular mechanism by which AmB adheres to the membrane of erythrocytes is the key factor in causing AmB to be toxic to the membrane of erythrocytes, but it is not yet fully understood; the mechanism by which AmB adheres to the liquid microdomains with higher fluidity formed by cholesterol and unsaturated phospholipids remains especially unclear. This study examined the adsorption of AmB at different concentrations, 5, 45, 85, and 125 μg/mL, on unsaturated phospholipid membranes containing 50 mol% cholesterol. The thermodynamic properties and structure of DOPC monolayers and DOPC/cholesterol mixed monolayers at different concentrations of AmB have been investigated using the Langmuir monolayer model and the BAM method. The impact of varying concentrations of AmB on the hydrophilic and hydrophobic domains of the DOPC bilayers and the DOPC/cholesterol mixed bilayers have also been discussed using large unilamellar vesicle liposomes and fluorescence techniques. It is shown that for AmB concentrations greater than 5 μg/mL, with an increase in AmB’s concentration, the reorganization time for the DOPC/cholesterol monolayer increases, and the elastic modulus of the DOPC/cholesterol mixed monolayer decreases. In particular, when AmB’s concentration is higher than 85 μg/mL, the liquid-condensed phase domains on the DOPC/cholesterol monolayer reduce significantly and the liquid-expanded phase domain enlarges from the BAM images. When the AmB concentration reaches 5 μg/mL, the disorder of the hydrophobic and hydrophilic domains of the DOPC/cholesterol bilayer increases as the AmB concentration increases. The way in which AmB interacts with the DOPC/cholesterol mixed membrane is related to the concentration of AmB. The higher the concentration of AmB, the more likely it is to remove cholesterol from the unsaturated phospholipid membrane. The results are helpful to understand the mechanism of AmB’s toxicity to the erythrocyte’s membrane, which has a guiding value for seeking ways to reduce the AmB’s toxicity.
Single-Crystalline Nanowires of Molecular Ferroelectric Semiconductors for Optoelectronic Memory
Authors: Qiu Xinxia , Xu Mingsheng , Cong Chunxiao , Qiu Zhi-Jun , Hu Laigui , Liu Ran
Published: November 2024

Though much progress has been achieved in the discovery of new molecular ferroelectrics in recent years, practical applications and related physics are still rarely explored due to the difficulty in high-quality film production and patterning issues. Single-crystalline films and patterns are in high demand for high device performance. Through a template-assisted space-confined strategy, herein, ordered single-crystalline nanowire patterns and optoelectronic devices of a semiconducting molecular ferroelectric (SMF), hexane-1,6-diammonium pentaiodobismuth (HDA-BiI5), were successfully demonstrated. The coupling of semiconducting and ferroelectric polarization of the SMF devices enables a broadband self-powered photodetection from ultraviolet to visible light, as well as polarization-tunable photoresponsivity. These may open an avenue for high-performance SMF optoelectronic memory devices with low cost and flexibility.
Menthol-Induced Chirality in Semiconductor Nanostructures: Chiroptical Properties of Atomically Thin 2D CdSe Nanoplatelets Capped with Enantiomeric L-(−)/D-(+)-Menthyl Thioglycolates
Authors: Skrypnik Maria Yu. , Kurtina Daria A. , Karamysheva Sofia P. , Stepanidenko Evgeniia A. , Vasil’eva Irina S. , Chang Shuai , Lebedev Alexander I. , Vasiliev Roman B.
Published: November 2024

Semiconductor colloidal nanostructures capped with chiral organic molecules are a research hotspot due to their wide range of important implications for photonic and spintronic applications. However, to date, the study of chiral ligands has been limited almost exclusively to naturally occurring chiral amino and hydroxy acids, which typically contain only one stereocenter. Here, we show the pronounced induction of chirality in atomically thin CdSe nanoplatelets (NPLs) by capping them with enantiopure menthol derivatives as multi-stereocenter molecules. L-(−)/D-(+)-menthyl thioglycolate, easily synthesized from L-(−)/D-(+)-menthol, is attached to Cd-rich (001) basal planes of 2- and 3-monolayer (ML) CdSe NPLs. We show the appearance of narrow sign-alternating bands in the circular dichroism (CD) spectra of 2 ML NPLs corresponding to heavy-hole (HH) and light-hole (LH) excitons with maximal dissymmetry g-factor up to 2.5 × 10−4. The most intense CD bands correspond to the lower-energy HH exciton, and in comparison with the N-acetyl-L-Cysteine ligand, the CD bands for L-(−)-menthyl thioglycolate have the opposite sign. The CD measurements are complemented with magnetic CD measurements and first-principles modeling. The obtained results may be of interest for designing new chiral semiconductor nanostructures and improving understanding of their chiroptical properties.
Self-Powered Photodetectors with High Stability Based on Se Paper/P3HT:Graphene Heterojunction
Authors: Yu Xuewei , Huang Yuxin , Li Pengfan , Feng Shiliang , Wan Xi , Jiang Yanfeng , Yu Pingping
Published: November 2024

Photodetectors based on selenium (Se) have attracted significant attention because of their outstanding optoelectronic characteristics, including their rapid reactivity and high photoconductivity. However, the poor responsivity of pure Se limits their further development. In this study, a novel Se-P/P3HT:G photodetector was designed and fabricated by combining an organic semiconductor made of poly-3-hexylthiophene mixed with graphene (P3HT:G) with self-supporting Se paper (Se-P) via spin-coating process. The device possesses a dark current of around 4.23 × 10−12 A and self-powered characteristics at 300–900 nm. At zero bias voltage and 548 nm illumination, the Se-P/P3HT:G photodetector demonstrates a maximum photocurrent of 1.35 × 10−9 A (745% higher than that of Se-P at 0.1 V), a quick response time (16.2/27.6 ms), an on/off ratio of 292, and a maximum detectivity and responsivity of 6.47 × 1011 Jones and 34 mA W−1, respectively. Moreover, Se-P/P3HT:G exhibits superior environmental stability. After one month, the photocurrent value of the Se-P/P3HT:G device held steady at 91.4% of its initial value, and even following pre-treatment at 140 °C, the on/off ratio still remained 17 (at a retention rate of about 5.9%). The excellent thermal stability, environmental reliability, and optoelectronic performance of this heterojunction structure offer a useful pathway for the future advancement of high-performance optoelectronic devices.
Body Composition Trend in Slovene Adults: A Two-Year Follow-Up
Authors: Jakše Boštjan , Fras Zlatko , Godnov Uroš
Published: November 2024

This research re-evaluates the prevalence of obesity in a cohort of 432 Slovenian adults two years after an initial population-based cross-sectional examination, utilizing the World Health Organization’s body mass index (BMI) and total body fat percentage (FAT%) classifications. Herein, a medically approved electrical bioimpedance monitor was used to analyse body composition, and the results revealed a significant increase in the percentage of individuals classified as having overweight or obesity on the basis of BMI, from 40.7% initially to 45.2% at follow-up (FU); however, these percentages were notably higher in males than in females. The increases in body mass, BMI, fat mass, and FAT% were observed mainly in adult females, whereas in adult males, the increases in BM and BMI were attributed to fat-free mass (FFM) rather than fat mass. In this study, BMI was also compared with the FAT% obesity classification, and the BMI classification was shown to result in significantly fewer participants with obesity in both measures. However, the proportion of participants with obesity based on the two classifications did not differ substantially between the initial and FU measurements. In this study, mixed linear models were used to analyse overall trends and subgroup variations and highlight the importance of considering sex, age, and time of measurement when assessing body composition metrics. These findings emphasize the need for personalized health assessments and the importance of measuring body composition to evaluate adult obesity more accurately for both clinical assessments and public health policies. The state, in collaboration with social initiatives and industrial stakeholders, should prioritize these data and advance public health through innovative educational and awareness initiatives that are founded on robust scientific principles and that empower and promote the adoption of a healthy, active lifestyle.
Consumption of Ultra-Processed Foods and Semen Quality in Healthy Young Men Living in Italy
Authors: Ceretti Elisabetta , Bonaccio Marialaura , Iacoviello Licia , Di Castelnuovo Augusto , Ruggiero Emilia , Donato Francesco , Lorenzetti Stefano , Zani Danilo , Montano Luigi
Published: November 2024

Background/Objectives: The study aim was to evaluate the association between UPF consumption and semen quality in a sample of healthy young men in Italy. Methods: A cross-sectional analysis was carried out using data from 126 participants (mean age ± SD 20.0 ± 1.2 years) enrolled in the FASt randomized controlled trial. Food intake was assessed through the European Prospective Investigation into Cancer and Nutrition (EPIC) FFQ. Food items were categorized according to the Nova classification based on their purpose and extent of processing as follows: (1) unprocessed/minimally processed foods; (2) processed culinary ingredients; (3) processed foods; and (4) UPFs. The weight ratio (%) between each Nova group (g/d) and total food (g/d) was then calculated. For semen analyses, sperm volume, concentration, motility and morphology were measured. The associations between UPF consumption (quarters of) and semen quality parameters were estimated using multivariable-adjusted linear regression models. Results: Participants consuming high UPFs (Q4), compared to those in the bottom category of intake (Q1), had a lower sperm concentration (β = −54.16 × 106 cell/mL; 95%CI: −92.91 to −15.40; p for trend = 0.0020 across fourths) and progressive motility (β = −14.17%; 95%CI: −28.25 to −0.09; p for trend = 0.036). The percentage of normal morphology cells had a tendency to decrease amongst subjects consuming more UPFs compared to those with the lowest intake. Conclusions: A large dietary intake of UPFs was inversely associated with sperm concentration and progressive motility in reproductive-age men. These findings suggest that dietary recommendations for improving male fertility and sperm health should also recommend limiting UPFs.
Interrelation of Stress, Eating Behavior, and Body Adiposity in Women with Obesity: Do Emotions Matter?
Authors: Gonçalves Irene da Silva Araújo , Filgueiras Mariana De Santis , Moreira Tiago Ricardo , Thomé Milena Sales , Paiva Gabrielly Luisa Diniz , Almeida Geralda Patrícia de , Cotta Rosangela Minardi Mitre , Campos Tatiana do Nascimento , Freitas Dayse Mara de Oliveira , Novaes Juliana Farias de , Oliveira Alex Fabrício de , Costa Glauce Dias da
Published: November 2024

Background/Objectives: Obesity is influenced by biological, hormonal, and social factors, contributing to chronic diseases and burdening the healthcare system. Chronic stress and emotional eating are linked to weight gain, affecting eating behaviors and metabolism. This study aimed to assess the association between stress, eating behavior, and adiposity in obese women. Methods: This cross-sectional study included 132 obese women from Viçosa, Minas Gerais, Brazil. The participants completed the Lipp Stress Symptoms Inventory and the Dutch Eating Behavior Questionnaire. Blood samples were collected to measure plasma cortisol, and Body Mass Index (BMI) was calculated from weight and height measurements. Body fat was assessed using dual-energy X-ray absorptiometry (DXA). Associations between stress, eating behavior, and adiposity were evaluated using linear regression models, and interactions between stress and eating behavior subscales were tested. Results: Positive associations were observed between Phases I (alert), II (resistance), and III (exhaustion) of stress with emotional and external eating. A negative association was identified between dietary restraint and body fat, especially in women with lower cortisol levels (<13.7 mg/dL). Additionally, the alert phase was associated with higher android fat in these women. Conclusions: The findings support the hypothesis that stress and eating behavior are associated with body adiposity and that stress is linked to emotional and external eating. An inverse association between restrained eating and body fat was observed in women with lower cortisol levels. These results highlight the importance of an interdisciplinary approach that incorporates emotional and stress conditions in obesity treatment.
The Immunomodulatory Role of Vitamin D in Regulating the Th17/Treg Balance and Epithelial–Mesenchymal Transition: A Hypothesis for Gallbladder Cancer
Authors: Cartes-Velásquez Ricardo , Vera Agustín , Torres-Quevedo Rodrigo , Medrano-Díaz Jorge , Pérez Andy , Muñoz Camila , Carrillo-Bestagno Hernán , Nova-Lamperti Estefanía
Published: November 2024

The etiology of gallbladder cancer (GBC) is multifactorial, with chronic inflammation resulting from infections, autoimmune diseases, and lifestyle factors playing a pivotal role. Vitamin D deficiency (VDD) has been implicated in the pathogenesis of autoimmune disorders and various malignancies, including GBC. Research on autoimmune diseases highlights the anti-inflammatory properties of vitamin D, suggesting its potential to mitigate disease progression. In oncology, VDD has similarly been linked to increased inflammation, which may contribute to both the initiation and progression of cancer. A critical component in carcinogenesis, as well as in the immunomodulatory effects of vitamin D in autoimmune conditions, is the balance between T-helper 17 (Th17) cells and regulatory T (Treg) cells. We hypothesize that vitamin D may inhibit epithelial–mesenchymal transition (EMT) in GBC by modulating the spatial distribution of tumor-infiltrating T cells, particularly through the regulation of the Th17/Treg balance at the tumor margins. This Th17/Treg imbalance may act as a mechanistic link between VDD and the progression of GBC carcinogenesis. Investigating the role of an Th17/Treg imbalance as a mediator in VDD-induced EMT in GBC not only provides deeper insights into the pathogenesis of GBC but also sheds light on broader mechanisms relevant to the development of other solid organ cancers, given the expanding recognition of the roles of VDD and Th17/Treg cells in cancer biology.
Managing Zinc Supplementation in Hemodialysis Patients: Balancing and Preventing Deficiencies in Serum Copper and Zinc Levels with and Without HIF-PH Inhibitors
Authors: Takahashi Akira
Published: November 2024

Background/Objectives: Zinc supplementation induces metallothionein, leading to reduced serum copper levels. Conversely, serum copper concentrations tend to rise with the use of HIF-PH inhibitors. Methods: To establish a safe level of zinc supplementation that avoids copper deficiency, serum copper and zinc concentrations measured every three months were retrospectively analyzed over five years in 50 patients undergoing hemodialysis. Results: At the initiation of the study, the median (IQR) concentrations were 100 (84.25–109) µg/dL for serum copper and 60.5 (50.5–70) µg/dL for serum zinc. All participants without zinc supplementation exhibited zinc deficiency (<80 µg/dL). After three months, copper deficiency (<71 µg/dL) was observed when serum copper concentrations were <98.6 µg/dL for patients with HIF-PH inhibitors and <90.3 µg/dL for patients without them. Reduced zinc supplementation may be necessary when serum copper falls below 90 µg/dL. Zinc levels remained deficient because supplementation was limited due to concerns about copper deficiency. Lowering the target zinc level to around 80 µg/dL instead of the conventional 80–120 µg/dL may be safer. Conclusions: Regular monitoring of both copper and zinc levels, taking place at least every three months, is recommended to adjust zinc supplementation, especially in patients on HIF-PH inhibitors. Copper supplementation should also be considered alongside zinc supplementation to effectively treat hypozincemia.
Anti-Obesity Effects of Pleurotus ferulae Water Extract on 3T3-L1 Adipocytes and High-Fat-Diet-Induced Obese Mice
Authors: Hong Seulmin , Park Seonkyeong , Lee Jangho , Park Soohyun , Park Jaeho , Lee Yugeon
Published: November 2024

This study offers promising insights into the anti-obesity potential of Pleurotus ferulae, an edible mushroom valued in Asian cuisine for its nutritional benefits. A hot water extract of P. ferulae (PWE) administered to high-fat diet-induced obese mice over an 8-week period significantly reduced their body weight gain and fat accumulation. PWE not only improved the body weight metrics but also positively influenced the serum lipid profile of obese mice by lowering their total cholesterol and low-density lipoprotein cholesterol levels. In vitro studies using 3T3-L1 adipocytes showed that PWE inhibited adipocyte differentiation and lipid accumulation by downregulating key adipogenic transcription factors, particularly PPARγ and C/EBPα, as well as related lipogenic genes involved in fat synthesis and storage, such as Fabp4, Fasn, and Scd1. Chemical analysis revealed that PWE is rich in polysaccharides, which have been associated with various health benefits, including anti-obesity, anti-diabetic, and anti-cancer properties. These findings suggest that the bioactive compounds in PWE may serve as functional food components that could potentially be applied for the prevention and management of obesity and other metabolic disorders.
Indoor and Outdoor Air Microbial Contamination During Different Reconstruction Methods of Historic Buildings
Authors: Lippai Anett , Leelőssy Ádám , Magyar Donát
Published: November 2024

The quality of indoor air is dependent on a number of factors, including the presence of microorganisms that colonize the building materials. The potential for health risks associated with microbial contamination is a significant concern during the renovation of buildings. The aim of this study was to assess the impact of two reconstruction methods for historic buildings on air quality. The two reconstruction procedures were facadism, which preserves only the façade, demolishing the rest of the building and constructing a new building, and complete reconstruction, which involves internal renovation with a less intensive demolition. A total of 70 + 70 air samples, as well as surface and dust samples, were collected throughout the course of the reconstruction of the two buildings. In the case of facadism, total colony counts were found to be 2–4 times higher indoors than outdoors, even at the initial stage of the works. High concentrations of Aspergillus and Penicillium spp. were detected. During the less intensive reconstruction, the total colony count in the indoor air samples was initially lower at almost every sampling point than at the outdoor levels. With regard to fungi, Penicillium species were initially present at lower conidia concentrations, followed by Aspergillus species over time. In both buildings, elevated concentrations of airborne fungi were detected during the main reconstruction period. The fungal genera found in the indoor air were also detected on surfaces and in dust samples. Outdoor air samples collected from the vicinity of the buildings revealed elevated fungal counts at multiple sampling points, particularly in the case of facadism. Disinfection with dry fogging was implemented twice throughout the entire interior of the buildings. Following the first disinfection process, there was no notable decrease in colony-forming unit (CFU) counts in either building. However, the second disinfection resulted in a reduction in microbial concentration in the air. Our study confirms that the renovation of historical buildings can result in an elevated prevalence of fungal bioaerosols, which can be harmful to occupants. While the impact of the reconstruction remained within the range of urban background variability at distant (>1 km) locations, it caused local microbial contamination, often exceeding the detection limit in near-site samples.
Colistin Resistance Mechanism and Management Strategies of Colistin-Resistant Acinetobacter baumannii Infections
Authors: Islam Md Minarul , Jung Da Eun , Shin Woo Shik , Oh Man Hwan
Published: November 2024

The emergence of antibiotic-resistant Acinetobacter baumannii (A. baumannii) is a pressing threat in clinical settings. Colistin is currently a widely used treatment for multidrug-resistant A. baumannii, serving as the last line of defense. However, reports of colistin-resistant strains of A. baumannii have emerged, underscoring the urgent need to develop alternative medications to combat these serious pathogens. To resist colistin, A. baumannii has developed several mechanisms. These include the loss of outer membrane lipopolysaccharides (LPSs) due to mutation of LPS biosynthetic genes, modification of lipid A (a constituent of LPSs) structure through the addition of phosphoethanolamine (PEtN) moieties to the lipid A component by overexpression of chromosomal pmrCAB operon genes and eptA gene, or acquisition of plasmid-encoded mcr genes through horizontal gene transfer. Other resistance mechanisms involve alterations of outer membrane permeability through porins, the expulsion of colistin by efflux pumps, and heteroresistance. In response to the rising threat of colistin-resistant A. baumannii, researchers have developed various treatment strategies, including antibiotic combination therapy, adjuvants to potentiate antibiotic activity, repurposing existing drugs, antimicrobial peptides, nanotechnology, photodynamic therapy, CRISPR/Cas, and phage therapy. While many of these strategies have shown promise in vitro and in vivo, further clinical trials are necessary to ensure their efficacy and widen their clinical applications. Ongoing research is essential for identifying the most effective therapeutic strategies to manage colistin-resistant A. baumannii. This review explores the genetic mechanisms underlying colistin resistance and assesses potential treatment options for this challenging pathogen.
Coordination of Carbon and Nitrogen Metabolism Through Well-Timed Mid-Stage Nitrogen Compensation in Japonica Super Rice
Authors: Hu Qun , Zhang Kaiwei , Jiang Weiqin , Qiu Shi , Li Guangyan , Xu Fangfu , Zhu Ying , Liu Guodong , Gao Hui , Zhang Hongcheng , Wei Haiyan
Published: November 2024

The carbon and nitrogen (N) metabolism of rice under different mid-stage N compensation timings is unclear. Two Japonica super rice cultivars were examined under four N compensation timings (N1-N3: N compensation at mid-tillering, panicle initiation, and spikelet differentiation. N0: no N compensation) and CK with no N application. Mid-stage N compensation increased the N concentrations of various tissues, and N2 showed the highest plant N uptake at both the heading stage, maturity, and the grain filling period. Among the treatments, N2 showed the highest N utilization efficiency. With delayed compensation timing, there was a gradual decrease in soluble sugar and starch concentrations in each tissue, accompanied by a decline in the non-structural carbohydrate (NSC) concentration. Specifically, N2 treatment exhibited the highest NSC accumulation and the remobilized NSC reserve, but NSCs per spikelet decreased with delayed compensation timing. The highest yield was also obtained with N2, exhibiting a 4.5% increase compared to the N0 treatment, primarily due to an improvement in spikelets per panicle. Conclusively, N compensation at the panicle initiation stage is a reasonable N management strategy that can coordinate the improvement of carbon and N metabolism, enhance N accumulation with efficient utilization and NSC accumulation, and ultimately increase the yield.