bluuebunny/crossref_metadata_2025 huggingface dataset:
Improving Sustainable Performance for MSMEs Through Halal Supply Chain Management
Authors: Jannah Syayyidah Maftuhatul , Wijayanti Dwi Marlina
Published: February 2025

The purpose of this study is to examines the impact of implementing ten aspects related to halal supply chain management on its effectiveness, particularly in improving sustainability across economic, social, and environmental dimensions for MSMEs. The research adopts a quantitative research approach, collecting data through a self-administered survey conducted among MSMEs located in Yogyakarta, Indonesia. The results of the data analysis using SEM-PLS. The results indicate that six aspects of halal supply chain management significantly contribute to upholding halal integrity, enhancing customer satisfaction and branding, and improving process quality. Additionally, a higher implementation of these aspects is directly linked to an enhancement in the sustainable performance of MSMEs. This research provides insight that MSMEs still need to be fostered in implementing Halal Supply Chain Management.
Estimating Expected Default Probability and Credit Risk Spread Using the KMV Merton Model: A Case Study of Bank Islam Malaysia Berhad
Authors: Septiana Nurul Izzati , Katri Fatin Salwa Binti Haji , Ideris Azlina Binti , Noryatim Nadiana
Published: February 2025

The objective of the paper is to estimate the expected default probability and credit risk spread of Bank Islam Malaysia using the KMV Merton Model and analyse the strengths of the KMV model. The data used in this research are short term and long-term liabilities data of Bank Islam Malaysia Berhad that we obtained from the financial statements, stock prices and number of stocks traded of BIMB and Islamic Bank-relevant interest rates data that we obtained from the Overnight Policy Rate Decision (OPR) by Bank Negara Malaysia. The data is then prepared and interpolated to match weekly period before applying the KMV Model using Microsoft Excel to calculate the default probability and credit risk spread of BIMB. The result shows that the Probability of Default for BIMB is nearly 0.0001 for the first 3 years of its debt maturity period and nearly 0.0007 and 0.002 for the maturity period of 4 and 5 years respectively. Credit risk spread for BIMB is nearly null for the first 2 years maturity period then gradually increases each year to 0.01, 0.05 and 0.14. BIMB’s distance to default ranges between 9.17-10.01. The research indicates that the BIMB’s calculated PD is reliable and that the KMV Merton Model provides high accuracy and reliability of credit risk measurements. The KMV Model can be applied to different types of companies including Islamic Bank.
Faktor- Faktor yang Mempengaruhi Tingkat Profitabilitas Bank Umum Syariah Di Indonesia
Authors: Arsal Muryani , Rusli Andi Musyarrafah , Badoahi Ismail
Published: February 2025

This aims of study to examine the effect of financial ratios which is Capital Adequacy Ratio (CAR), Operating Costs Operating Income (BOPO), Non Performing Financing (NPF), Financing to Deposit Ratio (FDR), and Inflation Rate on profitability in Sharia Commercial Banks in Indonesia for the 2018-2022 period. This research used  quantitative research where using secondary data from the financial reports of Sharia Commercial Banks. The data analysis technique used is multiple linear regression. The research results show that BOPO, NPF, and FDR have a significant effect on profitability, while CAR and the Inflation Rate do not have a significant effect. This research contributes to understanding the factors that influence the profitability of Sharia Commercial Banks in Indonesia, so that it can be a consideration for management in making strategic decisions regarding financial management and bank operations.
Evaluasi Penerapan Kebijakan Pajak Natura Berdasarkan PMK Nomor 66 Tahun 2023
Authors: Purba Lady Chintya , Rosid Arifin
Published: February 2025

The Indonesian Government issued Minister of Finance Regulation Number 66 of 2023 as an implementing regulation of Government Regulation Number 55 of 2022. This new regulation aims to regulate the Income Tax treatment of income or compensation concerning work or services received in-kind. A study was conducted to evaluate the performance of PT. GXX in implementing the in-kind tax policy contained in PMK Number 66 of 2023. The research focused on examining the Company's tax system based on the principles contained in the Tax Control Framework. PT GXX operates in the logistics and offshore services sector, providing in-kind facilities to employees such as transportation, credit, accommodation in offshore locations, etc. The study was a single case study using a descriptive qualitative approach based on case studies. The evaluation results demonstrate that PT GXX can develop effective tax strategies by deeply understanding regulations and identifying areas impacted by the implementation of in-kind taxes. With substantial support from its tax consultants, the company can establish necessary control processes and document the entire tax implementation process. Proper division of duties and responsibilities and regular monitoring and internal audits can lead to a successful implementation of new tax regulations following the principles of TCF. Despite facing challenges such as a lack of government-provided socialization and training, PT GXX has shown its commitment to adopting TCF principles in implementing new tax regulations. Thus, this research provides recommendations for providing training to deepen tax knowledge further, create clear standard operating procedures, and maintain a proactive attitude and good communication between internal teams.
Pengaruh Literasi Keuangan, Inklusi Keuangan, Gaya Hidup, Dan Financial Technology Terhadap Perilaku Keuangan Pegawai PT. X di SUMUT
Authors: Nasution Abdillah Arif , Balatif Muhammad Rijal
Published: February 2025

This research aims to analyze the influence of financial literacy, financial inclusion, lifestyle, income and financial technology on the financial behavior of PT X. This research is associative research and the type of data used is quantitative data. The population in this study was 178 people who were employees of PT. X with a sampling technique using purposive sampling. The data analysis techniques used are descriptive statistical analysis and multiple linear regression. The results of this research show that financial literacy, financial inclusion, lifestyle, income and financial technology simultaneously have a significant influence on the financial behavior of PT X. Partially, financial literacy has a positive and insignificant effect on the financial behavior of PT X, financial inclusion has a positive and significant effect on the financial behavior of PT X, lifestyle has a positive and significant effect on the financial behavior of PT X, income has a positive and insignificant effect on the financial behavior of PT X, financial technology has a positive and insignificant effect on the financial behavior of PT X. The most dominant influence on financial behavior is financial inclusion.
Peran Moderasi Komitmen Organisasi dalam Hubungan Faktor Personal Auditor dan Deteksi Kecurangan di Sektor Publik
Authors: Kusuma Mahardhika Hadi , Firmansyah Amrie
Published: February 2025

This research aims to examine the effect of auditor personal factors on the ability of auditors to detect fraud with organizational commitment as a moderator. The research was conducted with the auditors of the Supreme Audit Agency. The resource persons were selected from the population based on purposive sampling and the final sample used in this research was 64. Data analysis was carried out using a structural equation model. The results show that the auditor's personal factors positively affect the auditor's ability to detect fraud. However, organizational commitment failed to moderate the relationship between these two variables. This condition is thought to be because most respondents are employees with long service periods, so organizational commitment is not an important factor in detecting fraud. This research contributes to fraud literature and contributes to stakeholders in formulating human resource policies. Furthermore, testing auditors' ability to detect fraud in the public sector is still rare in previous literature, especially with goal orientation and self-efficacy. In addition, the use of organizational commitment as a moderating variable in this relationship can complement the public sector audit literature in Indonesia.
Membangun Kinerja Pegawai Melalui Efektivitas Audit Internal di Perbankan Syariah Maluku Utara
Authors: Zamzam Irfan , Mukarramah Sitti
Published: February 2025

This study aims to analyze the influence of internal audit effectiveness on employee performance in Islamic banking in North Maluku. Internal audit plays a crucial role in ensuring that company operations adhere to applicable standards and regulations, as well as in detecting and preventing potential errors and fraud. Employee performance in the Islamic banking sector is the primary focus, as optimal performance is key to achieving organizational goals and sustainability. This research employs a quantitative method with data collection techniques through questionnaires distributed to employees of several Islamic banks in the North Maluku region. Data analysis is conducted using linear regression to measure the extent to which internal audit effectiveness impacts employee performance. The results indicate a significant positive relationship between internal audit effectiveness and employee performance, suggesting that effective internal audits can enhance employee performance in Islamic banking. These findings provide important implications for Islamic bank management to strengthen the internal audit function as an effort to improve performance and operational effectiveness.
Peran Iklim Integritas dalam Menjelaskan Pengaruh Kepemimpinan Etis terhadap Pelanggaran Integritas di Sektor Publik
Authors: Simarmata Jhon Kenedy , Permana Warji , Kawedar Warsito
Published: February 2025

Government has recently paid more attention to the integrity of civil servants in providing public services. This is an effort to create a service environment that is free from corruption and able to provide excellent service to the public. Therefore, this study attempts to explain the effect of ethical leadership on integrity violations through the integrity climate in public sector organizations. This research was conducted at one of the institutions in Indonesia that has units spread across all provinces in Indonesia. Using a systematic random sampling design, 442 employees were selected who were then asked to fill out a questionnaire. Total of 393 employees were willing to fill out the research questionnaire which was then processed for analysis. PLS-SEM is used for multivariate analysis and data processed using the SmartPLS 3 application. The results of the analysis show that integrity climate is statistically proven mediating the effect of ethical leadership on integrity violations. These results provide empirical support for the Social Learning Theory which explains that individual behavior is the result of learning from their environment. To mitigate integrity violations in organizations, leaders are expected to be role models of ethical behavior to their subordinates, as well as building a integrity climate in organization.
Pengaruh Tarif Pajak, Kepercayaan Penggunaan Dana, dan Pemahaman Akuntansi terhadap Kepatuhan Pajak Melalui Religiusitas
Authors: Herman Herman , Chaidir Randy , Arliani Fitri
Published: February 2025

This research examines taxpayer compliance in Micro, Small and Medium Enterprises using three independent variables, namely tax rates, confidence in the use of funds, and understanding of accounting. What is used as an intervening variable is religious characteristics. The research was carried out by distributing questionnaires to Micro, Small and Medium Enterprises in Balikpapan. The total number of questionnaires distributed was 115 and 88 samples met the requirements for processing. The method used is regression analysis using SmartPLS 3 software. This research found that there is a positive but not significant effect of the tax rate variable on tax compliance, trust in the use of funds has a positive and significant effect on tax compliance, accounting understanding has a positive and significant effect on tax compliance. , religiosity has a positive but not significant effect on tax compliance, while religiosity, when it is an intervening variable, has no effect on tax compliance. Tax rates have no effect on tax compliance through religiosity, trust in the use of funds has no effect on tax compliance through religiosity, and understanding accounting has no effect on tax compliance through religiosity. This shows that a person's religious nature is not able to have an impact on taxpayers' perceptions of the tax rates applied by the government, it does not have an impact on taxpayers' perceptions of integrity and government policies, religious nature has no impact on taxpayers' perceptions of increasing their accounting knowledge. on taxpayer compliance in paying taxes
Analisis Faktor-Faktor Konsumen Terhadap Purchase Intention Sepeda Listrik Menggunakan TAM3
Authors: Belananda Maulia Regita , Ian Muhammad Rezki , Jamal Jamal
Published: February 2025

of people's strong purchasing power and the reasonable cost of electric bicycles. Purposive sampling was employed in questionnaire sampling. Because this study has forty indikator items, it requires a sample size of 200 respondents. The TAM3 model, which has 17 variables, is used in the research model. Only three variables—Subjective Norm, work relevance, and Output Quality—are known to be partially significant and to positively impact Perceived Usefulness . Five factors are identified as partially significant determinants of Perceived Ease of Use; three factors are positively correlated: Self-efficacy, Playfulness, and enjoyment; the other two are negatively correlated: Anxiety and Objective Usability. Perceived Usefulness  and Perceived Ease of Use are partially known to have a positive and significant influence on Behavioral Intention. Then it is known that Behavioral Intention has a positive and significant influence on Purchase Intention.
Evaluasi Peran Audit Internal dalam Penerapan Manajemen Risiko (Studi Kasus pada Kementerian Keuangan)
Authors: Sukmawan Huda , Prasetya Machmudin Eka
Published: February 2025

Audit internal sebagai lini ketiga berperan untuk memastikan manajemen sebagai pemilik risiko dalam menerapkan manajemen risiko yang efektif. Tujuan penelitian ini untuk mengevaluasi peran audit internal yang dijalankan oleh Inspektorat Jenderal sebagai lini ketiga dalam penerapan manajemen risiko di Kementerian Keuangan. Pendekatan yang digunakan dalam penelitian ini adalah pendekatan kualitatif dengan jenis studi kasus pada organisasi yang telah menerapkan kerangka Three Lines Model. Evaluasi audit internal atau Inspektorat Jenderal sebagai lini ketiga dalam penerapan manajemen risiko menggunakan KMK-322/2021 yang merupakan penyesuaian dari kerangka COSO Internal Control-Integrated Framework (COSO ICIF) dan peran audit internal yang disarankan oleh The Institute of Internal Auditors (IIA). Analisis penelitian ini menggunakan metode triangulasi dengan membandingkan hasil yang diperoleh dalam wawancara dan dokumen yang berkaitan untuk menerangkan substansi dari konteks masalah yang diteliti. Wawancara dilakukan kepada pengelola manajemen risiko dan auditor internal yang melakukan pengawasan terkait manajemen risiko. Sumber dokumen yang digunakan dalam analisis merupakan dokumen peraturan dan laporan kegiatan pengawasan manajemen risiko yang disusun audit internal. Hasil penelitian menunjukkan peran Inspektorat Jenderal sebagai lini ketiga telah mencakup seluruh komponen dan prinsip-prinsip pada COSO ICIF dan peran yang disarankan oleh IIA. Namun, masih terdapat peran yang perlu disempurnakan pada komponen penilaian risiko dan kegiatan pemantauan. Pada komponen penilaian risiko, Inspektorat Jenderal belum melakukan pengujian dalam keselarasan risiko fraud pada setiap level organisasi. Selanjutnya pada komponen kegiatan pemantauan, aktivitas pemantauan kepatuhan yang dijalankan masih terfokus pada level kantor pusat sehingga diperlukan perluasan ruang lingkup pengawasan pada level unit vertikal.
Pengungkapan Perbankan Hijau dan Kinerja Bank Syariah di Indonesia: Eksplorasi Hubungan dan Peran Moderasi Regulasi
Authors: Khomsatun Siti , Aryani Habsyah Fitri , Pramesti Adista Ika
Published: February 2025

The impact of globalization on economic growth has been predominantly negative, as widely noted. There is a need for environmental responsibility, including within Islamic banking. The environmental responsibility of Islamic banking aligns with the fundamental objectives of Sharia or maqashid sharia. Therefore, the aim of this study is to explore the relation of green banking disclosure and the maqasid shariah performance. The second objective is to investigate the moderating role of regulations on the relation of green banking disclosure and maqashid Shariah performance. This research utilizes 92 observations from 16 Islamic banks from 2017 to 2023, with employing an unbalanced panel data. Moderated regression analysis is conducted for each dimension of green banking disclosure. The findings indicate that green banking disclosure related to employees and customers dimension positively impact on maqashid sharia performance, which is the daily operational dimension of green demonstrates a significant negative.  While the policy dimension of green banking shows no effect. Another finding of this study is the absence of evidence for moderation by regulation SEOJK No. 16 of 2021. However, if using 10% significance level, moderation role of regulation indicates that regulations weaken the negative effect of daily operational dimensions on maqashid Sharia performance.
Подходы к расчету кратности, дисперсности и устойчивости воздушно-механических пен низкой кратности
Authors: Камлюк Андрей Николаевич
Published: February 2025

Цель. Теоретически оценить влияние основных факторов, влияющих на кратность, дисперсность и устойчивость воздушно-механической пены, получаемой в устройствах для пожаротушения.
Методы. В процессе исследований применялись теоретические и эмпирические методы анализа.
Результаты. В результате анализа теоретических и экспериментальных данных по исследованию пен выявлены основные факторы, влияющие на численные значения их кратности, дисперсности и устойчивости. Установлено, что кратность, дисперсность и устойчивость таких пен существенно зависят от способа генерирования, геометрических характеристик устройств, скорости подаваемого раствора пенообразователя и его физико-механических свойств.
Область применения исследований. Результаты анализа могут быть применены при разработке пеногенерирующих устройств, а также для определения оптимальных режимов их работы.
Relação entre polifarmácia e saúde mental em idosos: Uma revisão sistemática
Authors: Souza Ana Vitória de , Garcia Geovanna Borges Ribeiro , Marcacini Maria Eduarda Paiva
Published: February 2025

Introdução: A polifarmácia, caracterizada pelo uso concomitante de múltiplos medicamentos, é comum em idosos devido à presença de diversas comorbidades. Objetivo: Analisar a relação entre a polifarmácia e a saúde mental em idosos, com foco no desenvolvimento ou agravamento de transtornos como depressão e declínio cognitivo. Metodologia: Realizou-se uma revisão sistemática nas bases CAPES, BVS e SciELO, considerando artigos publicados entre 2019 e 2024, em inglês, português ou espanhol, de acesso aberto e disponíveis na íntegra. Foram incluídos estudos com idosos (≥ 60 anos) que abordassem a influência da polifarmácia na saúde mental e excluídos aqueles que não tratassem diretamente dessa relação, não estivessem acessíveis ou fossem publicados antes de 2019. Resultados: Dos 12 estudos analisados, 10 indicaram uma correlação negativa entre polifarmácia e saúde mental, evidenciando aumento dos sintomas depressivos. Entretanto, alguns estudos apontaram benefícios, como a proteção contra o declínio cognitivo, quando a polifarmácia é monitorada adequadamente. Conclusão: A gestão inadequada da polifarmácia pode agravar transtornos mentais e comprometer a qualidade de vida dos idosos. Há necessidade de ampliar pesquisas sobre seus impactos, considerando tanto riscos quanto potenciais benefícios.
Limites e avanços na prática pedagógica: Métodos e recursos no ensino de Matemática no Ensino Superior
Authors: Luçoli Rosangela , Azambuja Rosa Maria da Motta
Published: February 2025

Este artigo investiga os limites e avanços na prática pedagógica do ensino de matemática no ensino superior, com base em uma pesquisa qualitativa realizada em um centro universitário de Santa Catarina. O objetivo do estudo foi compreender as percepções docentes sobre os desafios do ensino de matemática e identificar avanços na oferta de recursos pedagógicos e tecnológicos. A metodologia adotada foi qualitativa, com entrevistas semiestruturadas aplicadas a docentes bacharéis dos cursos de Administração e Ciências Contábeis, cujos dados foram analisados segundo a abordagem de análise de conteúdo de Bardin. Os resultados revelam que os principais desafios dos alunos incluem deficiências nos conteúdos matemáticos básicos, dificuldades de interpretação e ansiedade matemática. Já os docentes destacam a necessidade de contínuo aprimoramento pedagógico, a adaptação a diferentes perfis de aprendizagem e a busca por estratégias didáticas mais dinâmicas. Em relação aos avanços, as disposições são um maior uso de tecnologias educacionais e uma crescente valorização de metodologias ativas, sem menção a avanços pedagógicos ou didáticos. No debate com os autores destacando, Zabalza, Masetto, Valdeleón, Acosta e Ramírez, Chevellard, Shulmann, Hill. Ball e Schiling, Carrillo-Yañez, Climent, conclui-se que a profissionalização do ensino e a sistematização das práticas são essenciais para superar os desafios e melhorar a qualidade do ensino da matemática.
Síndrome metabólica em pacientes vivendo com HIV/AIDS acompanhados em um hospital terciário do Ceará
Authors: Santos Virna Costa dos , Francilino Filho José Roberto Gomes , Lima Amanda Almeida , Lima Luan Victor Almeida
Published: February 2025

Introdução: Observa-se um número crescente de Pacientes Vivendo com HIV/AIDS (PVHA) acima de 50 anos, que necessitando de bom controle viral e de prevenção e manejo de doenças crônicas, como a Síndrome Metabólica (SM). Objetivo: Avaliar os fatores de risco para SM em PVHA. Métodos: Trata-se de um estudo observacional, transversal, retrospectivo, com uma coorte de PVHA acompanhados em um hospital terciário. Resultados: O estudo envolveu 195 pacientes. Destes, 71 com SM e 124 sem. Dos pacientes com SM, a maioria apresentou um Índice de Massa Corporal (IMC) elevado: 54,9%, pressão arterial não controlada: 69%, alterações em HDL: 90% dos homens, 95,2% das mulheres, Triglicerídeos: 62% e Glicemia: 85%. O valor de Carga Viral e CD4 foi irrelevante, a maioria estava indetectável: 83,1% e com CD4 >350: 87,1%. Conclusão: De forma geral, IMC elevado, dislipidemia e pior controle glicêmico foram os fatores mais contribuintes para SM nessa amostra.
Controle glicêmico em pacientes com Diabetes Mellitus no jejum pré-operatório - Revisão integrativa
Authors: Abreu Maisa de Castro , Lopes Caroline Melo , Lima Nathalia Xavier de , Mendes Kathiane Magalhães
Published: February 2025

Objetivou-se revisar e mapear literaturas existentes sobre controle glicêmico em pacientes diabéticos submetidos ao jejum pré-operatório, identificar os fatores de risco envolvidos, considerando estratégias de manejo e controle para possíveis complicações e fornecer uma visão geral das evidências disponíveis. Metodologia: Trata-se de uma revisão integrativa da literatura, utilizando a estratégia PICO para realizar a busca de artigos científicos, revisões integrativas, meta-análises, diretrizes e protocolos clínicos. Sendo a população foco do estudo, adultos e idosos com Diabetes Mellitus submetidos a intervenções cirúrgicas. Incluindo estudos atuais, dentro do período de 5 anos, de 2019 a 2024. Serão excluídos da revisão estudos envolvendo pacientes pediátricos, pacientes não diabéticos, procedimentos não cirúrgicos e estudos que não avaliem o controle glicêmico no jejum. Resultados: A revisão abrangeu 16 estudos principais e as demais referências complementares permitiram uma análise ampla do controle glicêmico em pacientes diabéticos submetidos ao jejum pré-operatório. Os achados evidenciaram que o monitoramento e o controle glicêmico criterioso no perioperatório reduzem significativamente o risco de complicações, incluindo infecções de sítio cirúrgico, atrasos na cicatrização, instabilidade hemodinâmica, resistência insulínica por consequência da hiperglicemia e hipoglicemia. Conclusão: A implementação de estratégias de controle glicêmico não apenas reduz os riscos associados à procedimentos cirúrgicos, como também melhora a qualidade de vida dos pacientes diabéticos, promovendo uma recuperação mais rápida e segura.
Análise exploratória e modelagem estatística de dados clínicos em pacientes com insuficiência cardíaca
Authors: Mantovani Dorival , Pereira Laura Maria de Araújo , Soares Nel Cione Gomes , Pereira Layza Cherollin de Lima , Urtiga Marfran José Cunha , Guedes Talyta Valeria Siqueira do Monte , Silva Júnior José Guedes da
Published: February 2025

A insuficiência cardíaca é uma das principais causas de mortalidade global, o que demanda estratégias para a prevenção e o tratamento. Este estudo tem como objetivo realizar uma análise exploratória de 299 pacientes com insuficiência cardíaca e investigar a influência de diferentes variáveis clínicas por meio de modelagens estatísticas. Foram aplicados modelos estatísticos de regressão linear e logística para avaliar o impacto de variáveis como idade, creatinina sérica, sódio sérico, hipertensão, anemia e tabagismo na fração de ejeção (volume sistólico) e na mortalidade dos pacientes. Os resultados indicaram que o nível de sódio sérico tem impacto significativo na fração de ejeção, enquanto idade, creatinina sérica e fração de ejeção obtiveram uma relação estatisticamente significativa com o risco de óbito. As conclusões deste estudo estão em consonância com achados prévios da literatura, destacando a importância dos biomarcadores laboratoriais na avaliação prognóstica da insuficiência cardíaca. A identificação desses fatores pode contribuir para a tomada de decisão clínica e o desenvolvimento de abordagens terapêuticas mais direcionadas, auxiliando na melhoria da sobrevida e qualidade de vida dos pacientes afetados pela doença.
Construction and validation of an instrument to assess the risk of suicide in Emergency and Psychosocial Care services
Authors: Alves Andréa Cristina , Ribeiro Maria Inês Lemos Coelho , Almeida Derica Karoly Evarista , Ferreira Hiran Nonato Macedo , Ferreira Karine Viana , Sousa Nágella Thaysa Bier de , Moura Francine Bom Conselho Peixoto Pereira
Published: February 2025

This article aimed to build and validate a protocol to be inserted into software to assess suicide risk, being a methodological development study carried out in three stages. In the first stage, the content was validated, through 5 judges, who were experts who work in teaching and research in the area of mental health and suicidology. After validating the content (protocol), the second stage was carried out, which consisted of the construction of the software by IT professionals. In the third stage, the software was validated in terms of applicability and usability. The study invited 19 participants, 17 professionals who work in the health network (urgency/emergency and mental health) of a municipality located in the north of the Minas Gerais triangle and two experts in the Information Technology (IT) field, who evaluated the interface and usability criteria. To validate all stages, participants used the Likert scale. The instrument obtained 80% agreement from judges regarding content, appearance, and consistency for assessing the risk of suicide in Emergency and Psychosocial Care services.
Fatores de risco de doença renal crônica em acadêmicos de Medicina da região Centro-Oeste
Authors: Santos Gabriel Cerqueira , Coelho Eduardo Chaves Ferreira , Abdala Guilherme Fontes de Sousa Skaf , Freire Ricardo Silva , Almeida Carolina Moura , Souza Danilo Borges de , Santos Luciana da Ressureição
Published: February 2025

A Doença Renal Crônica (DRC) possui elevada morbimortalidade em todo o mundo, com uma prevalência de 7,2% em indivíduos acima de 30 anos e entre 28 a 46% em indivíduos acima dos 64 anos. Nesse sentido, a doença se apresenta de forma assintomática ou oligossintomática em suas fases iniciais e se torna evidente em estágios avançados. Sobre tal perspectiva, é de suma importância avaliar os fatores que contribuem para a instalação desta comorbidade, visto a multifatoriedade que apresenta. O objetivo do presente estudo é identificar a prevalência de fatores de risco para DRC em acadêmicos de medicina. Trata-se de um estudo observacional transversal de amostras não pareadas. O estudo foi iniciado em 2020, com a coleta dos primeiros dados e concluído com nova coleta em 2022. Dessa maneira, foram analisados os fatores: idade, etnia, sexo, tabagismo, índice de massa corporal (IMC), hipertensão arterial (HA), diabete mellitus (DM), dislipidemia, dieta hiperproteica, história familiar de DRC, história familiar de doenças crônicas não transmissíveis. Existem possíveis causas para isso, como, maior carga horária de estudos, disponibilidade de tempo para o autocuidado e práticas saudáveis no dia a dia; vulnerabilidade dos estudantes quanto ao tabagismo e etilismo, já que maioria dos estudantes, são jovens e, por isso, podem ser influenciados pelo meio em que estão inseridos. Por fim, das comorbidades avaliadas, dislipidemia foi a mais prevalente na amostra, seguida de HAS e DM; e quanto ao histórico familiar, HAS foi a afecção mais frequente.
Análise da função pulmonar e espessura diafragmática no pós-operatório de cirurgia abdominal superior em pacientes hospitalizados no hospital universitário do Oeste do Paraná
Authors: Bonetti Karoline , Rosa Hellen Gonçalves , Beraldo Ana Luiza , Albuquerque Carlos Eduardo de
Published: February 2025

O presente estudo teve como objetivo investigar e comparar a espessura diafragmática (EP) e a função pulmonar em pacientes no pós-operatório (PO) de cirurgia abdominal superior em relação a indivíduos saudáveis. Trata-se de um estudo piloto com desenho comparativo transversal, realizado em um hospital universitário, com 30 participantes divididos em dois grupos: 15 pacientes no PO de cirurgia abdominal superior e 15 indivíduos saudáveis. Foram avaliadas a EP por ultrassonografia à beira do leito e a função pulmonar por espirometria, considerando a capacidade vital forçada (CVF), fração diafragmática e proporção de ativação muscular. Os resultados mostraram que o EP durante a inspiração foi significativamente menor no grupo PO (p 0,0417). A CVF também foi inferior em pacientes cirúrgicos (p 0,0012), prejudicando a função pulmonar. No entanto, a ativação muscular do diafragma foi maior no grupo PO (p 0,0448), proporcionando uma compensação para a perda de espessura muscular. A fração diafragmática não apresentou diferença estatisticamente significativa entre os grupos. Conclui-se que após uma cirurgia abdominal superior ocorre um maior recrutamento de unidades motoras como estratégia para manter a ventilação. A ultrassonografia mostrou-se uma ferramenta útil para a avaliação da disfunção diafragmática no PO, podendo auxiliar no monitoramento desses pacientes.
Conductas, actitudes y prácticas bioéticas en profesionales de Odontología
Authors: Mora Guevara Joselyn Milena , Ríos Jiménez Jennifer Gabriela , Valverde Camila Alejandra , Litardo Ochoa María Esthela , Siguencia Cruz Valeria del Rosío
Published: February 2025

El objetivo del presente estudio examinar las conductas, actitudes y prácticas bioéticas de los profesionales en la odontología, detectar deficiencias en su formación y en la aplicación de principios éticos, además, plantear estrategias para fortalecer la ética en el ejercicio de la profesión. La investigación se realizó mediante una revisión narrativa de la literatura, recopilando información de bases de datos como Scielo, Google Scholar, PubMed y Dialnet. Se incluyeron artículos publicados entre 2002 y 2024 en inglés y español, con términos de búsqueda relacionados con la bioética en odontología. Los resultados evidenciaron que, aunque los estudiantes de odontología muestran una actitud positiva hacia la bioseguridad, existen deficiencias en la enseñanza de esta disciplina, lo que afecta su capacidad para enfrentar dilemas éticos. Además, el uso de redes sociales en odontología ha generado problemas relacionados con el consentimiento informado y la privacidad del paciente. También se destaca la importancia de la empatía y la comunicación en la relación profesional-paciente. El estudio concluye que es urgente fortalecer la formación en bioética, integrar la enseñanza teórica y práctica en los programas académicos y establecer regulaciones claras sobre la publicidad odontológica y el uso de redes sociales, con el fin de garantizar una práctica ética y centrada en el bienestar del paciente.
PHYSICAL CAPACITY OF SPINA BIFIDA AND FACTORS AFFECTING DURING PREGNANCY: A CASE CONTROL STUDY
Authors: Arca Muhammed , Elbir Sultan , Asena Muhammet , Saka Gunay
Published: February 2025

: It was aimed to evaluate the physical characteristics of the cases with spina bifida and to review the factors that may affect the etiology of the disease. 48 cases with spina bifida and 48 control groups in other disease groups evaluated. A physiotherapist physically evaluated the cases after their personal information was obtained. A survey form examining the possible factors in the etiology of spina bifida was applied to the families. It was found in the physical examination of the cases that 45.8% had hydrocephalus, and 41.7% had movement restriction due to muscle weakness. When the two groups were compared, lower level of maternal literacy, residence in a rural area, undergoing an infectious disease during pregnancy, drug utilization during pregnancy, and not utilizing folic acids during pregnancy were significantly higher than the control group (p< 0.05). Spina bifida was increased by place of residence of family (OR: 2.8, CI: 1.11-7.08), infectious disease during pregnancy (OR: 5.0, CI: 1.05-24.05), and not using folic acid during pregnancy (OR: 3.8, CI: 1.04-13.76). Spina bifida was more common in females and caused extensive leg limitations. It was observed that education, place of residence and conditions experienced during pregnancy had an impact on the disease.
Ensuring Indigenous Peopleâ€™s Rights Protection Through Normative Law in Land Acquisition for Indonesiaâ€™s New National Capital City, Nusantara
Authors: Permadi Iwan , Dungga Weny Almoravid , Arshad Azhani
Published: February 2025

The development of Indonesiaâ€™s new capital, Ibu Kota Nusantara (IKN) or the Nusantara Capital City, involves land acquisition, potentially impacting the rights of indigenous peoples. This study evaluates the effectiveness of normative law in protecting these rights during the land acquisition process. Using a normative method, it examines relevant laws, regulations, jurisprudence, and academic literature through qualitative analysis. The findings reveal that while a robust legal framework exists to protect indigenous rights, implementation challenges persist. Key issues include determining fair compensation, land ownership recognition, relocation, and cultural preservation. Addressing these problems requires improved synergy and refinement of laws and regulations. The study highlights the critical need to bridge the gap between normative legal provisions and real-world practices. It emphasizes a holistic approach involving the government, indigenous communities, and stakeholders to achieve equitable and sustainable development. By offering operational legal solutions, the research underscores the importance of consistent legal application to respect indigenous rights. The findings call for multidisciplinary studies to tackle the complexities of protecting indigenous peoples in large-scale development projects. Strengthening legal mechanisms and fostering inclusive collaboration are essential for ensuring development aligns with the rights and needs of indigenous communities.
Cyanobacterial type I CRISPR-Cas systems: distribution, mechanisms, and genome editing applications
Authors: Zhang Yongjiu , Yang Shuxiao , Zheng Xianliang , Tan Xiaoming
Published: February 2025

Cyanobacteria, renowned for their photosynthetic capabilities, serve as efficient microbial chassis capable of converting carbon dioxide into a spectrum of bio-chemicals. However, conventional genetic manipulation strategies have proven incompatible with the precise and systematic modifications required in the field of cyanobacterial synthetic biology. Here, we present an in-depth analysis of endogenous CRISPR-Cas systems within cyanobacterial genomes, with a particular focus on the Type I systems, which are the most widely distributed. We provide a comprehensive summary of the reported DNA defense mechanisms mediated by cyanobacterial Type I CRISPR-Cas systems and their current applications in genome editing. Furthermore, we offer insights into the future applications of these systems in the context of cyanobacterial genome editing, underscoring their potential to revolutionize synthetic biology approaches.
Estimating erosion resistance of vegetated sea dike embankments through in situ experiments
Authors: Mozer Anne , Almström Björn , Olsson Pål Axel , Schüttrumpf Holger
Published: February 2025

Through in situ experiments, this study investigated the erosion resistance of a prototype dike with different vegetation and soil sections built on the Falsterbo peninsula, Sweden. A gravity-driven wave impact simulator was used to simulate waves breaking on the dike. Two sandy soils and three vegetation types (standard grass, biodiverse seed mixture, and hay) were tested for this study. In general, the study showed consistency in the results between the replications and in comparison to former studies. Thus, initially developed for laboratory experiments, the methodology can be transferred to in situ experiments on existing dikes. The study showed comparable results for higher biodiverse vegetation cover and standard grass regarding the resistance to wave impact. The importance of not only root but also soil parameters could be confirmed. A higher resistance was found with higher root densities and lower fine fractions in the soil. Also, a higher forb diversity resulted in larger root densities. Future studies could build on the present findings by conducting a systematic investigation to gain deeper insights into the impact of vegetation and soil properties.
3D connective micro-fragment enriched with stromal vascular fraction in osteoarthritis: chondroprotective evidence in a preclinical in vivo model
Authors: Desando Giovanna , Tschon Matilde , Martini Lucia , Sartori Maria , Giavaresi Gianluca , Fini Milena , Cellamare Antonella , Soranzo Carlo , Longinotti Cristina , D’Alessandro Martina , Roseti Livia , Grigolo Brunella
Published: February 2025

Introduction

Adipose-derived cell therapies are one of the most common regenerative therapeutic options to alleviate the multi-component damage of osteoarthritis (OA). Adipose stromal vascular fraction (SVF) has gained scientific consensus for its ability to interact protectively with the joint microenvironment. Recently, the wide range of enzyme-free tissue processing systems has outperformed classical treatments, because of their ability to produce connective micrografts enriched with the SVF (mctSVF). This preclinical in vivo study evaluates the chondroprotective potential of a newly generated mctSVF compared with in vitro expanded adipose stromal cells (ASC) in OA.

Methods

A mild grade of OA was induced through bilateral anterior cruciate ligament transection (ACLT) surgery in 32 Specific Pathogen Free (SPF) Crl: KBL (NZW) male rabbits followed by the surgical excision of inguinal adipose tissue. After 2 months, OA joints were treated with an intra-articular (IA) injection of mctSVF or ASC. Local biodistribution analysis was used to determine migration patterns of PKH26-labelled cells in the knee joint after 1 month. Efficacy was assessed by gross analysis, histology and immunohistochemistry on the osteochondral unit, synovial membrane and meniscus.

Results

We elucidate the effectiveness of a one-step approach based on mechanical isolation of mctSVF. Through epifluorescence analysis, we found a similar pattern of cell distribution between cell treatments, mainly towards articular cartilage. Similar regenerative responses were observed in all experimental groups. These effects included: (i) osteochondral repair (promotion of typical anabolic markers and reduction of catabolic ones); (ii) reduction of synovial reactions (reduced synovial hypertrophy and inflammation, and change of macrophage phenotype to a more regenerative one); and (iii) reduction of degenerative changes in the meniscus (reduction of tears).

Discussion

Our study demonstrates the validity of a novel mechanical system for the generation of the mctSVF micrograft with chondroprotective potential in a preclinical model of moderate OA. The resulting final product can counteract inflammatory processes beyond the OA microenvironment and protect cartilage through the colonization of its structure. The intact and active microanatomy of mctSVF makes it a suitable candidate for translational medicine to treat OA without the need for cell manipulation as with ASC.
Filtered and unfiltered lipoaspirates reveal novel molecular insights and therapeutic potential for osteoarthritis treatment: a preclinical in vitro study
Authors: Behn Alissa , Brendle Saskia , Ehrnsperger Marianne , Zborilova Magdalena , Grupp Thomas M. , Grifka Joachim , Schäfer Nicole , Grässel Susanne
Published: February 2025

Introduction

Orthobiologics, such as autologous nanofat, are emerging as a potential treatment option for osteoarthritis (OA), a common degenerative joint causing pain and disability in the elderly. Nanofat, a minimally processed human fat graft rich in stromal vascular fraction (SVF) secretory factors, has shown promise in relieving pain. This study aimed to elucidate the molecular mechanisms underlying nanofat treatment of OA-affected cells and compare two filtration systems used for nanofat preparation.

Methods

Chondrocytes and synoviocytes were isolated from articular cartilage and synovium of 22 OA-patients. Lipoaspirates from 13 OA-patients were emulsified using the Adinizer® or Lipocube™ Nano filter systems to generate nanofat. The fluid phase of SVF from both filtered and unfiltered lipoaspirates was applied to OA-affected cells. Luminex multiplex ELISA were performed with lipoaspirates and cell supernatants alongside functional assays evaluating cell migration, proliferation, metabolic activity, and senescence.

Results

A total of 62 cytokines, chemokines, growth factors, neuropeptides, matrix-degrading enzymes, and complement components were identified in lipoaspirates. Among these, significant concentration differences were observed for TIMP-2, TGF-ß3, and complement component C3 between the filtered and unfiltered samples. Nanofat enhanced chondrocyte proliferation and migration, as well as synoviocyte migration and metabolic activity, while reducing chondrocyte metabolic activity. Pain-related factors like β-NGF, MCP-1, Substance P, VEGF, and αCGRP were reduced, while anti-inflammatory TGF-β1+3 increased and pro-inflammatory cytokines (IL-5, IL-7, IL-15, and IFN-γ) decreased. Nanofat also elevated secretion of complement components and TIMPs in both cell types. Notably, our results revealed no significant differences in cellular effects between sSVF filtered using the Adinizer® and Lipocube™ Nano systems, as well as compared to unfiltered sSVF.

Discussion

Here, we provide first insights into how autologous nanofat therapy may ameliorate OA by enhancing chondrocyte proliferation and synoviocyte migration while modulating inflammatory and pain-related factors. However, further research is needed to determine its effects on cartilage regeneration.
Designing novel cabozantinib analogues as p-glycoprotein inhibitors to target cancer cell resistance using molecular docking study, ADMET screening, bioisosteric approach, and molecular dynamics simulations
Authors: Thakur Gajendra Singh , Gupta Ajay Kumar , Pal Dipti , Vaishnav Yogesh , Kumar Neeraj , Annadurai Sivakumar , Jain Sanmati Kumar
Published: February 2025

Introduction

One of the foremost contributors to mortality worldwide is cancer. Chemotherapy remains the principal strategy for cancer treatment. A significant factor leading to the failure of cancer chemotherapy is the phenomenon of multidrug resistance (MDR) in cancer cells. The primary instigator of MDR is the over expression of P-glycoprotein (P-gp), a protein that imparts resistance and facilitates the ATP-dependent efflux of various anticancer agents. Numerous efforts have been made to inhibit P-gp function with the aim of restoring the effectiveness of chemotherapy due to its broad specificity. The main objective has been to create compounds that either serve as direct P-gp inhibitors or interact with cancer therapies to modulate transport. Despite substantial in vitro achievements, there are currently no approved drugs available that can effectively “block” P-gp mediated resistance. Cabozantinib (CBZ), a multi-kinase inhibitor, is utilized in the treatment of various carcinomas. CBZ has been shown to inhibit P-gp efflux activity, thereby reversing P-gp mediated MDR. Consequently, P-gp has emerged as a critical target for research in anti-cancer therapies.

Methods

The purpose of this study was to computationally identify new andsafer analogues of CBZ using bioisosteric approach, focusing on improved pharmacokinetic properties andreduced toxicity. The physicochemical, medicinal, and ADMET profiles of generated analogues were computed using the ADMETLab 3.0 server. We also predicted the drug likeness (DL) and drug score (DS) of analogues. The molecular docking studies of screened analogues against the protein (PDB ID: 3G5U) were conducted using AutoDock Vina flowing by BIOVIA Discovery Studio for visualizing interactions.Molecular dynamics (MD) simulation of docked ligands was done using Schrödinger suite.

Results and Discussion

The docking scores for the ligands CBZ01, CBZ06, CBZ11, CBZ13, CBZ25, CBZ34, and CBZ38 ranged from −8.0 to −6.4 kcal/mol against the protein (PDB ID: 3G5U). A molecular dynamics (MD) simulation of CBZ01, CBZ13, and CBZ38 was conducted using the Schrödinger suite, revealing that these complexesmaintained stability throughout the 100 ns simulation.

Conclusion

An integrated computational approach combining bioisosteric approach, molecular docking, drug likeness calculations, and MD simulations highlights the promise of ligands CBZ01 and CBZ13 as candidates for the development of potential anticancer agents for the treatment of various cancers.