bluuebunny/crossref_metadata_2025 huggingface dataset:
Exploring Factors Influencing Consumer Purchase Decisions: A Study on UMKM Junior Baby
Authors: Tribianti Reza Nanda , Rizal Asat
Published: November 2022

This study examines the influence of product quality, price, and brand image on consumer purchase decisions in UMKM Junior Baby. Using quantitative methods and primary data, this research collected responses from 90 customers in Sidoarjo, Indonesia. Multiple linear regression analysis was employed to analyze the data with SPSS version 18. The results indicate that product quality, price, and brand image collectively exert a significant influence on consumer purchase decisions. Enhanced product quality, appropriate pricing, and a positive brand image positively affect consumers' willingness to make purchases. These findings contribute to understanding the factors that drive consumer behavior in the context of UMKM Junior Baby and have implications for practitioners seeking to optimize their marketing strategies.

Highlights:

Product quality: The study examines the impact of product quality on consumer purchase decisions, emphasizing the importance of delivering high-quality products to enhance customer satisfaction and drive sales.

Price: The research investigates the influence of pricing strategies on consumer purchase decisions, highlighting the significance of offering competitive prices that align with product value to attract and retain customers.

Brand image: The study explores the role of brand image in shaping consumer purchase decisions, emphasizing the need for UMKM Junior Baby to establish a positive and recognizable brand identity that resonates with their target market.

Keywords: product quality, price, brand image, purchase decisions, UMKM Junior Baby
Profitability, Firm Size, and Capital Structure: Implications for Firm Value in Food & Beverages Manufacturing
Authors: Nilamsari Zahrina , Hariasih Misti
Published: November 2022

This study examines the relationship between profitability, firm size, capital structure, and firm value in the Food & Beverages Manufacturing sector over the period 2016-2020. Purposive sampling was used to select a sample of eight companies, and secondary data from the Stock Exchange Gallery at Muhammadiyah University of Sidoarjo were analyzed using the path analysis technique and SmartPLS software. The findings reveal that profitability positively and significantly influences capital structure, while firm size has a negative and insignificant impact. Additionally, profitability has a positive and significant effect on firm value, while firm size has a negative and insignificant influence. Furthermore, firm size positively affects firm value. Notably, profitability has a positive and significant effect on firm value, mediated by capital structure, whereas firm size has a negative and insignificant effect on firm value through capital structure mediation. These findings contribute to the understanding of the factors shaping firm value in the Food & Beverages Manufacturing industry and offer implications for practitioners and policymakers seeking to optimize capital structure decisions and enhance firm performance.

Highlights:

Profitability positively influences capital structure in the Food & Beverages Manufacturing industry.

Firm size does not significantly impact capital structure in the sector.

Profitability has a significant positive effect on firm value, while firm size has a negligible impact.

Keywords: Profitability, Firm Size, Capital Structure, Firm Value, Food & Beverages Manufacturing.
Workload, Fatigue, Family Conflict: Impact on Outpatient Medical Workers in Sidoarjo
Authors: Oktaviona Aulya , Ambarwati Rita
Published: November 2022

This research study aimed to analyze and explain the condition of outpatient medical personnel during the COVID-19 pandemic at a Type D Hospital in Sidoarjo. The study focused on the increasing number of COVID-19 cases among patients and the occurrence of infections among non-medical employees. A quantitative approach was employed, utilizing an interval-level data collection method through observation, questionnaire distribution, and a saturated sample technique involving outpatient medical personnel. The study findings revealed that workload and work fatigue had a positive and significant impact on the performance of medical personnel. Additionally, the level of family conflict was found to have a positive effect on their performance. These results highlight the crucial factors influencing the performance of outpatient medical personnel during the pandemic, emphasizing the need for support and interventions to optimize their well-being and effectiveness in managing the ongoing crisis.

Highlights:

Workload and work fatigue significantly impact the performance of medical personnel during the Covid-19 pandemic.

The level of family conflict influences the performance of outpatient medical workers.

Understanding the effects of workload, work fatigue, and family conflict is crucial for supporting and optimizing the well-being of medical personnel during the pandemic.

Keywords: Workload, Work Fatigue, Family Conflict, Outpatient Medical Workers, Covid-19.
Social Media & Music Videos: Ethics Impact on Grade 6 Students
Authors: Arifin Rizky Alfiyah , Wardana Mahardika Darmawan Kusuma
Published: November 2022

The purpose of this study was to determine the impact of the tik-tok application on students' communication ethics in an elementary school located in Sidoarjo Regency. The approach used in this research is qualitative with the type of case study research. The subjects in this study were high school students at SDN Kalisampurno 1 Tanggulangin. Based on the results of the study, it was concluded that the use of the tik-tok application had a positive impact on students being more daring to admit when they made mistakes and being responsible, and excessive ones could have a negative impact on students' communication ethics. This can be seen from the results of research which shows that there are still many students who do not meet the indicators of good communication ethics in behaving in school. Highlights: The study examines the impact of the TikTok application on communication ethics of elementary school students in Sidoarjo Regency. The research follows a qualitative approach, specifically a case study design. Findings suggest that TikTok has both positive and negative effects on students' communication ethics, with some students demonstrating good ethics while others fall short. Keywords: TikTok application, Communication ethics, Elementary school students, Sidoarjo Regency, Qualitative research
Powering Elementary Civics Education: Enhancing Active Learning and Performance
Authors: Rahmawati Mauludiana , Kurniawan Machful Indra
Published: November 2022

This research addresses the issue of passive student engagement and teacher-centered learning approaches in primary schools. To overcome these challenges, the study employs Microsoft PowerPoint as an instructional medium to enhance the learning experience. A Pre-Experimental Design research method is employed, conducted at SD Negeri Pejangkungan with thirty fourth-grade students as participants. Data collection involves the use of tests, and the obtained results are subjected to t-test analysis. The findings reveal a significant positive impact of utilizing Microsoft PowerPoint media on students' civics learning outcomes, as indicated by tcount (24.686) exceeding ttable (2.045). Additionally, eta squared analysis demonstrates a considerable influence of Microsoft PowerPoint media on learning outcomes (0.95>0.14). These results emphasize the potential of Microsoft PowerPoint as an effective tool to promote active learning and enhance students' academic achievements in various educational settings.

Highlights:

Active Engagement: This research explores the use of Microsoft PowerPoint as a means to promote active learning among elementary students, addressing the issue of passive student engagement in the classroom.

Academic Improvement: The study investigates the impact of utilizing Microsoft PowerPoint on students' academic performance, specifically focusing on civics education, to determine the effectiveness of this instructional medium.

Experimental Design: The research employs a Pre-Experimental Design methodology, conducted at SD Negeri Pejangkungan with fourth-grade students, to gather data through tests and analyze the outcomes using statistical measures such as t-tests and eta squared.

Keywords: Active learning, Academic performance, Microsoft PowerPoint, Experimental study, Civics education.
Online Learning: Discipline and Responsibilities for Grade 3 Students Analysis
Authors: Zulfana Laili , Wahyuni Akhtim
Published: November 2022

This study aims to find out and analyze the disciplinary character and responsibility of students during offline learning. This study used a descriptive qualitative type. In this study, the data collection techniques used include observations, interviews, and documentation with the subject of 3 grade III students and 1 class III teacher. The results of this study show that after online learning students lack discipline in the aspect of arriving on time, abide by the rules or rules of the common/school. While in character responsibility students are lacking in terms of deeds and work on group assignments together. On the indicators of discipline students are good enough in doing or collecting assignments according to the specified time and follow the rules of good and correct language. Meanwhile, in the indicator of responsibility, students have carried out picketing well.

Highlights:

Offline learning and discipline: Highlighting the lack of discipline in arriving on time and following school rules after online learning.

Responsibility and group work: Emphasizing students' deficiency in terms of deeds and working on group assignments together.

Indicators of discipline and responsibility: Noting students' satisfactory performance in completing assignments on time and following rules of language, but also their successful picketing.

Keywords: offline learning, disciplinary character, responsibility, qualitative study, data collection techniques
Unleashing the SAVI Learning Model: Enhancing Grade IV Science Outcomes
Authors: Nimah Manzilatun , Wahyuni Akhtim
Published: November 2022

This quantitative research aimed to investigate the impact of the SAVI (Somatic, Auditory, Visual, and Intellectual) learning model on the cognitive learning outcomes of fourth-grade students in science at Ash-Shiddiqiyah Elementary School. The study employed an experimental design with a pre-test and post-test approach. The results revealed a significant improvement in students' cognitive learning outcomes, as evidenced by a t-test value of 18.589, surpassing the critical t-value of 2.131. The calculated effect size (eta squared) of 0.95 indicated a substantial influence of the SAVI learning model on the students' science learning outcomes. These findings have important implications for educators and policymakers, highlighting the potential of innovative teaching methodologies to enhance students' academic achievements in science education.

Highlights:

The study examines the impact of the SAVI learning model on cognitive learning outcomes in Grade IV Science.

The experimental design employed a pre-test and post-test approach to evaluate the effectiveness of the SAVI learning model.

The findings indicate a significant improvement in academic achievement, emphasizing the potential of innovative teaching methodologies.

Keywords: Cognitive learning outcomes, Grade IV Science, SAVI learning model, Experimental design, Academic achievement.
Parental Role and Student Interests: Impact on Math Learning Outcomes
Authors: Arsyatiara Fanny , Liansari Vevy
Published: November 2022

This study aimed to investigate the relationship between students' perceptions of parental roles, their learning interests, and mathematics learning outcomes in elementary schools. Non-experimental quantitative research methods with a correlational design were employed. Data were collected through questionnaires and documentation, and analyzed using SPSS with multiple correlation and regression tests. The results of the multiple correlation test indicated a non-significant correlation (Sig. F change = 0.705 > 0.05), suggesting no relationship between the variables. Similarly, the multiple regression test revealed that neither the perceived parental role (X1) nor learning interest (X2) had a significant correlation with mathematics learning outcomes (Y), as the t-values (0.710 and 0.430) were smaller than the critical t-value (2.086). The obtained value of R (0.185) fell within the uncorrelated category according to established guidelines. Consequently, it can be concluded that there is no significant relationship between students' perceptions of parental roles and learning interests on mathematics learning outcomes in elementary schools. These findings emphasize the need to explore additional factors that may influence students' academic achievements and to develop targeted interventions to enhance mathematics learning outcomes. 

Highlights:

Study investigated the relationship between parental roles, student interests, and math learning outcomes.

Non-experimental quantitative methods were used with correlational design.

No significant correlation found between parental roles, student interests, and math learning outcomes in elementary schools.

Keywords: Parental Role, Student Interests, Math Learning Outcomes, Elementary Schools, Correlation.
Student Reception of English Learning through Animated Videos in Sidoarjo Elementary Schools
Authors: Prameswari Areta Daffara , Astutik Yuli
Published: November 2022

This study aims to determine how students respond in learning English using animated videos in grade I SD PLUS FATIMAH AZ – ZAHRO' Sidoarjo. This research is a qualitative research in which the data is taken from the analysis of direct observation and interviews with English class teachers. Collecting data in this study using documentation and interviews. The data analysis technique uses data reduction, data presentation, and drawing conclusions. The results of this study indicate that student responses are divided into three components, namely cognitive, affective, and conative. This study also shows that students in one class are divided into three parts in the ability to understand English learning, namely the competent level, medium level, and low level. Lack of interest in learning English and internal and external factors such as family background and students' skills or abilities are one of the causes of students' lack of response to learning English.

Highlights: 

The study focuses on understanding student responses in learning English using animated videos in a specific grade and school in Sidoarjo.

The research employs qualitative methods, gathering data through direct observation, interviews with English teachers, and documentation.

The study identifies three components of student responses: cognitive, affective, and conative, and highlights the varying levels of English understanding among students. The lack of interest and external/internal factors also affect students' response to English learning.

Keywords: English learning, Animated videos, Student responses, Grade I, SD PLUS FATIMAH AZ – ZAHRO' Sidoarjo
Ethnomedicine Study of Areca Nut (Areca catechu L.) as Aphrodisiac by Traditional Indonesian Healers
Authors: Fauzi NFN , Mustofa Fanie , Widodo Harto
Published: November 2022

Areca nut (Areca catechu L.) is widely distributed in Indonesia, from the lowlands to an altitude of 1,000 m asl.  Areca nut has been used traditionally by various ethnic groups to treat male sexual disorders (aphrodisiac).  This paper aimed to determine the use of areca nut and other plants as a mixture of aphrodisiac ingredients by traditional healers in various ethnic groups in Indonesia.  The Health Research and Development Agency obtained the data from exploring local knowledge of ethnomedicine and community-based medicinal plants in Indonesia in 2012, 2015, and 2017 (RISTOJA).  The data were analyzed descriptively, and the use value of areca nut and other plants as aphrodisiacs was analyzed quantitatively.  The study’s results noted that 22 aphrodisiac ingredients used by 15 ethnic groups contained the main ingredient of the areca nut.  The root was the most widely used part of the areca nut in aphrodisiac ingredients (64%).  Besides areca nut, 38 other types of plants were also found in traditional aphrodisiac ingredients.  Most of these (33) plant species have been identified.  Based on the use value (0.1-0.6), plants that had the highest aphrodisiac use values as areca nut mixture were Imperata cylindrica (Poaceae) (0.6), Cocos nucifera (Arecaceae) (0.47), Carica papaya (Caricaceae) (0.2), Piper nigrum (Piperaceae) (0.20) and Zingiber officinale (Zingiberaceae) (0.20).  Further research was required to determine the best composition of traditional aphrodisiac ingredients that can provide health benefits for men’s erectile dysfunction.
Plan de negocio para la comercialización de jeans orgánicos en Lima Metropolitana (Perú)
Authors:   , Condori Letona Ruth Isaura , Julca Esteban Erika Yobana , Retamozo Escobar Alexander Luis , Salazar Alberco Jorge Luis
Published: November 2022

El actual plan de negocios tiene como propósito analizar la factibilidad del proyecto de negocio, estimando factores diferenciales, insertando el análisis financiero y económico. Se dio el nombre a la empresa como Eco Style S.A.C., se designó como denominación comercial del proyecto de negocio a Eco Style; que se dedicará a la comercialización de jeans orgánicos en Lima Metropolitana. Con nuestro jean orgánico nos preocupamos por el consumidor, porque un jean convencional tiene muchos químicos que afectan al ambiente y a la piel; sin embargo, nuestro jean orgánico estará elaborado con menos insumos químicos que dañen directamente a la piel y enfocándonos en ser eco amigables. Para alcanzar al segmento propuesto se empleará el marketing mix, lo cual posibilitará la formulación de estrategias adecuadas a fin de entablar una relación de comercialización y continuamente el cliente a través de un contacto digital conocerá el producto. La marca se lanzará al mercado en la etapa inicial con su principal producto eco amigable que serán los jeans orgánicos con el precio de venta de S/ 75.00 por unidad, proyectándonos a tener un rendimiento de S/ 177, 583.00 por año, equivalentemente con una TIR de 173%, concluyendo que el proyecto de negocio es factible y rentable en el tiempo.
Exportación de galletas elaboradas a base de harina de oca de Tayacaja (Huancavelica) hacia el mercado de Managua - Nicaragua
Authors:   , Peralta Yauri Jackelyn Claret , Amaro Blanco Cristina Angela , Delgado Rodriguez Jose Benjamin
Published: November 2022

El presente trabajo de investigación es un plan de negocio de exportación que busca diversas variables que se detecten en el mercado centroamericano, donde la compañía Innovation SAC se enfocará en la venta de galletas de oca hacia la ciudad de Managua-Nicaragua; por ende, se estudiará cada factor de la empresa, tanto dentro como fuera y teniendo en cuenta los elementos que identifican a la entidad. La comercialización de galleta de oca tiene como objetivo el mercado de Nicaragua, donde durante los últimos tiempos la alimentación de dicho mercado ha ido cambiando, hoy en día consumen más productos alimenticios sanos y llenos de nutrientes; por otro lado, existe una demanda que se debe satisfacer, contribuir y orientar a más personas para cambiar la mala alimentación y tener una vida saludable. Por otro lado, el presente proyecto tiene una tasa interna de retorno (TIR) del 87% y con respecto al valor actual neto (VAN) es de S/ 299,467.99 soles; por otra parte, se puede determinar que los flujos financieros y económicos son positivos y que el proyecto es totalmente viable y rentable. Para culminar se busca orientar a los estudiantes y empresas exportadoras a que exploren e investiguen nuevas oportunidades, en poder enviar productos con insumos naturales provenientes de la sierra peruana hacia el mercado centroamericano, viendo los beneficios y ventajas que este producto ofrece; y por otra parte, contribuir con el desarrollo económico del país.
Uso de la tomografía computarizada de haz cónico para el estudio de la densidad ósea en el tratamiento ortodóncico. Una revisión de la literatura.
Authors:   , Conde López Susana
Published: November 2022

El objetivo de este trabajo fue determinar la utilidad de la TCHC (Tomografía Computarizada de Haz Cónico) para la medición de la densidad ósea en tratamientos ortodóncicos mediante la revisión de la literatura. La aplicación de fuerzas en el tratamiento ortodóncico es la responsable de una serie de respuestas biológicas que se dan en el ligamento periodontal y hueso alveolar. En la remodelación ósea ocurre el proceso de reabsorción y aposición, en consecuencia, el nuevo hueso formado presenta una nueva densidad ósea. La DMO (Densidad Mineral Ósea) es la cantidad de minerales (por lo general calcio y fósforo) contenidos en un volumen de hueso, esto incluye porosidad, médula y matriz ósea. La adición de estos minerales es lo que hace que el hueso sea más o menos denso. Debido a esto, es importante cuantificar la DMO en pacientes previo a un tratamiento ortodóncico. La cuantificación de la DMO habitualmente se realiza con las Unidades Hounsfield (UH), medida estándar de la Tomografía Computarizada Médica (TCM), sin embargo, con el avance de la tecnología en odontología se empezaron a realizar mediciones de la DMO, con un equivalente a las UH, llamadas escala de valores de grises; esta variación de grises es la forma de cuantificar la DMO con la TCHC. Con este avance tecnológico se ha logrado una disminución en la cantidad de dosis de radicación al paciente; por consiguiente, menor tiempo de exposición, menor costo y mayor resolución; es por estas razones que se podría considerar a la TCHC una de la mejor opción para evaluar la DMO.
Precisión del método de Kvaal en la estimación de la edad dental mediante radiografías panorámicas digitales de adultos, año 2020
Authors:   , Izaguirre López Heikky Nicole
Published: November 2022

RESUMEN: Objetivo: Determinar la precisión del método de Kvaal en la estimación de la edad dental mediante el análisis de radiografías panorámicas digitales de pacientes entre 20 a 47 años atendidos en la clínica estomatológica de la Universidad Científica del Sur, (2018 a 2019), Lima – Perú. Materiales y métodos: se analizaron 289 radiografías panorámicas digitales pertenecientes a individuos de ambos sexos, de 20 a 47 años. Se obtuvo medidas de longitud y anchura en la cámara dental y pulpar en los incisivos centrales superiores. Estos datos se valoraron posteriormente al calcular las proporciones entre la pulpa y longitud de la raíz del incisivo central superior aplicando la fórmula del método de Kvaal y cols. para obtener la precisión del método en la estimación de la edad dental. Resultados: Al aplicar la fórmula de Kvaal y Cols. indica que la relación entre la anchura de pulpa y la longitud de la raíz presentan un nivel de significancia mayor en relación a otras proporciones: M valor medio de todas las proporciones excepto T (-0.659) y W-L: diferencia entre los valores de W y L (-0.643). El coeficiente de determinación (r2) y el error estándar de la estimación (SEE) utilizando la fórmula original de Kvaal es de r2: 0.70, SEE: 4.90 años, después se propuso una fórmula modificada de Kvaal para la población peruana. Conclusiones: El Método de Kvaal y cols. tiene una precisión del 1.24 en la estimación de la edad dental de los individuos, utilizando el incisivo central superior en radiografías panorámicas digitales.
Frecuencia y factores asociados al diagnóstico de Ehrlichia canis y Anaplasma spp. en caninos (Canis lupus familiaris) atendidos en la Clínica veterinaria municipal del Rímac durante el periodo 2018-2021
Authors:   , Carbajal Ruiz Antuane Jesus
Published: November 2022

Este estudio evalúa la cantidad de casos reportados de anaplasmosis y ehrlichiosis canina en el distrito del Rímac, así como su asociación con factores implicados en la presentación de estas enfermedades, la investigación es de tipo básico, transversal, retrospectivo y descriptivo. Se muestreó todas las historias clínicas del periodo 2018-2021 de pacientes caninos de la Clínica Veterinaria Municipal del Rímac ubicado en el distrito del Rímac, Lima – Perú, obteniendo 4.308% (224/5200) de historias clínicas donde se diagnosticó Ehrlichia canis y/o Anaplasma spp, además, se usó la prueba de chi cuadrado para evaluar la asociación con los factores sexo, raza, edad, y temporada del año, concluyendo que hubo asociación de las enfermedades con el grupo etario; y a un intervalo de confianza al 95% se indicó que la frecuencia de casos de E. canis y Anaplasma spp fue de 95.98% y 1.79%, respectivamente, y la co-infección de ambos patógenos fue de 2.23%.
Tratamiento de aguas residuales domésticas mediante el uso de humedales artificiales mejorados con las especies Cyperus papyrus y Phragmites australis
Authors:   , Valverde Quispe Fiorella Andrea
Published: November 2022

La polución del agua es ocasionada por efectos adversos siendo los factores antropogénicos los más contaminantes que los naturales. Los antropogénicos son causados por las aguas residuales derivadas de diversas actividades industriales, agrícolas y domésticas. Las aguas residuales presentan el problema en el 0,01% de su composición (sólidos suspendidos, disueltos y coloidales). Se aplican tratamientos convencionales como no convencionales (humedales artificiales); siendo las últimas un ejemplo de eco tecnología que se asemeja a un humedal natural. El objetivo de esta investigación es evaluar la eficiencia de cuatro prototipos de Humedales Artificiales Mejorados (HAM) con el uso de dos especies de macrófitas (Cyperus papyrus y Phragmites australis), la misma composición de sustratos, condiciones ambientales con un tiempo de retención hidraúlica de 3 días. El HAM 1, no presentó ninguna especie; HAM 2, cuatro individuos de C. papyrus; HAM 3, cuatro individuos de P. australis y el HAM 4, presentó dos individuos de cada especie. Los resultados obtenidos indicaron que el HAM 4 presentó un mejor desempeño, debido a que obtuvo porcentajes de remoción mayores que los otros prototipos para los parámetros fisicoquímicos. El HAM 3, obtuvo una reducción significativa de hasta un 99.9 % en Coliformes Termotolerantes a comparación del HAM 2 que obtuvo los niveles de remoción más bajos. El HAM 1 presentó porcentajes de remoción bajos en comparación de los demás prototipos disminuyendo su eficiencia. Finalmente, se concluye que la aplicación de los humedales artificiales mejorados para tratamiento de aguas residuales presenta reducciones significativas en los contaminantes del agua a un bajo costo.
El impacto del turismo receptivo sobre el crecimiento económico en el Perú durante el período 2003-2019
Authors:   , Garavito Espejo Rocio Denisse
Published: November 2022

El objetivo de esta investigación es determinar si el turismo receptivo ha tenido un efecto positivo sobre el crecimiento económico del Perú durante el período pre-pandemia 2003- 2019. Para ello, se estima la relación dinámica entre la tasa de crecimiento del turismo receptivo y la tasa de crecimiento de la actividad económica a través de un modelo de vector autorregresivo (VAR), a partir del cual se obtiene la respuesta dinámica de la actividad económica ante choques exógenos en el turismo receptivo. La identificación de los choques se realiza recursivamente utilizando la descomposición de Cholesky. Los resultados confirman la hipótesis de que el crecimiento del turismo receptivo tiene un impacto dinámico positivo y estadísticamente significativo sobre el crecimiento económico del PBI real total y del sector comercio durante el período pre-pandemia. Además, las pruebas de causalidad en el sentido de Granger indican que el crecimiento del turismo puede ser utilizado potencialmente como un indicador líder del crecimiento del PBI real.
Estrés laboral y su influencia en el desempeño laboral en profesionales de Lince-Perú. 2021
Authors:   , Molina Ortega Rosamelia Cristina , Schuler Trujillo Ilse Veriuska
Published: November 2022

El estrés es considerado como uno de los padecimientos que tiene mayor incidencia a nivel mundial, repercutiendo en la salud emocional, desempeño laboral y relaciones interpersonales por las afectaciones físicas y emocionales que conlleva. El objetivo del estudio fue determinar la relación del estrés con el desempeño laboral en profesionales de Lince. La investigación se basó en un diseño no experimental de enfoque cuantitativo, tipo básico, alcance descriptivo-correlacional. La muestra fue de 381 profesionales del distrito de Lince, a quienes se les aplicó dos cuestionarios. El primero cuantificó los niveles de estrés, con una confiabilidad por Alfa de Cronbach de (0,80) y el segundo para cuantificar el desempeño laboral con una confiabilidad de (0,891). Luego de los análisis estadísticos se determinó que las variables estrés y desempeño laboral en los profesionales de Lince guardan una relación significativa, inversa y moderada; por lo que, ante el aumento de nivel de estrés hay una reducción en el desempeño laboral de los trabajadores.
Precisión de la cirugía guiada por computadora del sistema Planmeca para la colocación de implantes dentales según el diseño de guía y el lugar de implantación
Authors:   , Cueva Principe Luis Alberto
Published: November 2022

Objetivos: Los sistemas de implantes dentales asistidas por una guía quirúrgica diseñada por computadora tiene ventajas frente al procedimiento convencional. El propósito de este estudio fue determinar la precisión del método de cirugía guiada por computadora del flujo CAD/CAM de Planmeca para la colocación de implantes dentales según el diseño de guía quirúrgica y según el lugar de colocación del implante. Materiales y métodos: Se realizó un estudio observacional retrospectivo. La muestra estuvo constituida por 56 implantes dentales colocados mediante guías quirúrgicas desarrolladas por el sistema CAD/CAM de Planmeca®, el cual incluyeron diseños de guías dentosoportadas, dentomucosoportadas y mucosoportadas e implantes colocados en todas las zonas de los maxilares. Se realizó la superposición de la planificación virtual a la tomografía de control para evaluar los parámetros de precisión de distancia plataforma, distancia ápice, desviación angular y profundidad implantar. Resultados: Los parámetros de precisión obtenidos fueron de 1.38 mm (±0.66) para la distancia de la plataforma, 1.63 mm (±0.97) para la distancia del ápice, 3.97º (±3.34º) para la desviación angular y 1.11 mm (±0.72) para la profundidad del implante. No se encontró diferencia significativa de los parámetros de precisión de acuerdo con el lugar de implantación en los maxilares, pero si diferencia significativa en la distancia de la plataforma (𝑝 = .0096) según el diseño de guía, en el cual las guías dentosoportadas fueron las que mejor precisión presentan. Conclusión: La precisión de los implantes colocados mediante guías quirúrgicas asistidas por computadora con el sistema CAD/CAM de Planmeca presentaron parámetros de precisión altos acorde a muchos antecedentes, siendo el diseño de guía un factor a considerar y en el cual se espera mejor precisión en las guías dentosoportadas.
Relación de los métodos de enseñanza en entornos virtuales y los estilos de aprendizaje en los estudiantes de Medicina en una universidad privada de Lima, 2021
Authors:   , Irribari Poicon Angel Omar
Published: November 2022

En este escenario de incertidumbre, producto del crecimiento de la ciencia y la tecnología, es requisito indispensable que los docentes de educación superior distingan las maneras de aprender de sus alumnos para poder vincularlo con su metodología de enseñanza, de tal forma que se propicie una experiencia educativa significativa y pertinente. En ese marco, el propósito de este estudio es determinar la relación entre los métodos de enseñanza y los estilos de aprendizaje en entornos virtuales en los estudiantes del primer y segundo año de medicina en una universidad privada de Lima, 2021. La investigación fue de alcance correlacional de diseño no experimental transeccional. La variable estilos de aprendizaje se midió a través del Cuestionario Honey Alonso de Estilos de Aprendizaje (CHAEA) y la variable métodos de enseñanza mediante la escala elaborada por Rojas (2018), los cuales fueron aplicados a 296 alumnos de primer y segundo año matriculados en la facultad de medicina en la sede Villa El Salvador. Los resultados demostraron que no existe una relación positiva entre los métodos de enseñanza y los estilos de aprendizaje en entornos virtuales de los estudiantes del primer y segundo año de Medicina en una Universidad Privada de Lima, 2021. Además, el estilo predominante fue el reflexivo.
Robust Method for Reservoir Simulation History Matching Using Bayesian Inversion and Long-Short-Term Memory Network-Based Proxy
Authors: Zhang Zhen , He Xupeng , AlSinan Marwah , Kwak Hyung , Hoteit Hussein
Published: November 2022

History matching is a critical process used for calibrating simulation models and assessing subsurface uncertainties. This common technique aims to align the reservoir models with the observed data. However, achieving this goal is often challenging due to the nonuniqueness of the solution, underlying subsurface uncertainties, and usually the high computational cost of simulations. The traditional approach is often based on trial and error, which is exhaustive and labor-intensive. Some analytical and numerical proxies combined with Monte Carlo simulations are used to reduce the computational time. However, these approaches suffer from low accuracy and may not fully capture subsurface uncertainties. This study proposes a new robust method using Bayesian Markov chain Monte Carlo (MCMC) to perform assisted history matching under uncertainties. We propose a novel three-step workflow that includes (1) multiresolution low-fidelity models to guarantee high-quality matching; (2) long-short-term memory (LSTM) network as a low-fidelity model to reproduce continuous time response based on the simulation model, combined with Bayesian optimization to obtain the optimum low-fidelity model; and (3) Bayesian MCMC runs to obtain the Bayesian inversion of the uncertainty parameters. We perform sensitivity analysis on the LSTM’s architecture, hyperparameters, training set, number of chains, and chain length to obtain the optimum setup for Bayesian-LSTM history matching. We also compare the performance of predicting the recovery factor (RF) using different surrogate methods, including polynomial chaos expansions (PCE), kriging, and support vector machines for regression (SVR). We demonstrate the proposed method using a water flooding problem for the upper Tarbert formation of the 10th SPE comparative model. This study case represents a highly heterogeneous nearshore environment. Results showed that the Bayesian-optimized LSTM has successfully captured the physics in the high-fidelity model. The Bayesian-LSTM MCMC produces an accurate prediction with narrow ranges of uncertainties. The posterior prediction through the high-fidelity model ensures the robustness and accuracy of the workflow. This approach provides an efficient and practical history-matching method for reservoir simulation and subsurface flow modeling with significant uncertainties.
Late-stage Peptide Modification and Cyclization via Maleimidation of C(7)-H Tryptophan
Authors: Wang Peng , Liu Jiang , Yan Zhengqing , Yan Jiahui , Jiang Jitong , Fu Manlin , Kenry Kenry , Zhu Qing
Published: November 2022

Cyclic peptides have attracted tremendous attention in the pharmaceutical industry owing to their excellent cell penetrability, stability, thermostability, and drug-like properties. However, the currently available facile methodologies for creating such peptides are rather limited. Herein, we reported an efficient and direct peptide cyclization via rhodium(III)-catalyzed C(7)-H maleimidation. Notably, this catalytical system has excellent regioselectivity and high tolerance of functional groups which enable late-stage cyclization of peptides. This new architecture of cyclic peptides exhibits higher bioactivity than its parent linear peptides. Moreover, the Trp-substituted maleimide displays excellent reactivity towards Michael addition, indicating its potential as new click functional group for applications in chemical biology and medicinal chemistry.
Identification of key immune-related genes in dilated cardiomyopathy using bioinformatics analysis
Authors: Li Feng , Du Tong-Yue , Wu Li-Da , Zhang Lei , Liu Huan-Huan , Zhang Zhen-Ye , Zhang Jie , Zhang Zhi-Yuan , Qian Ling-Ling , Hao Jian-Feng , Wang Ru-Xing
Published: November 2022

Background:
Dilated cardiomyopathy (DCM) is characterized by the left ventricular dilatation and impaired myocardial systolic dysfunction with high mortality and morbidity. However, the underlying mechanisms remain elusive.
Methods:
Differentially expressed genes (DEGs) analysis was performed using two expression profiles from GSE3585 and GSE84796. Enrichment analysis to explore the potential mechanisms underlying DCM was conducted. A total of four algorithms, including key module of MCODE, degree, maximum neighborhood component (MNC), and maximal clique centrality (MCC), were used within Cytoscape to identify the hub genes. Correlation analysis between hub genes and infiltrated immune cells to identify potential immune-related genes. The expression analysis and diagnosis value analysis of potential immune-related genes were performed. Finally, the expression analysis with GSE57338 and relationship analysis with the comparative toxicogenomics database (CTD) were performed for identification of the key immune-related genes in DCM.
Results:
A total of 80 DEGs were screened for DCM. Enrichment analysisrevealed that DEGs were involved in immune-related pathological process. Immune infiltration analysis indicated a potential immune response abnormal in DCM. Four up-regulated genes, including COL1A2, COL3A1, CD53, and POSTN, were identified as potential immune-related genes. Finally, three genes (COL1A2, COL3A1, and POSTN) were determined as the key immune-related genes in DCM via expression analysis with a validation set (GSE57338) and relationship analysis with CTD.
Conclusions:
Our study suggested that the upregulated COL1A2, COL3A1, and POSTN might be the key immune-related genes for DCM. Further studies are needed to validate the underlying mechanisms.
Characterizing Modifications to a Comparative Effectiveness Research Study – the OPTIMIZE Trial - Using the framework for reporting adaptations and modifications to evidence-based interventions (FRAME)
Authors: Greene Tom , Fritz Julie M , Brennan Gerard P. , Minick Kate , Lane Elizabeth , Wegener Stephen T. , Skolasky Richard L.
Published: November 2022

Background The OPTIMIZE trial is a multi-site, comparative effectiveness research (CER) study that uses a sequential multiple assessment randomized trial (SMART) designed to examine the effectiveness of complex health interventions (cognitive behavioral therapy, physical therapy and mindfulness) for adults with chronic low back pain. Modifications are anticipated when implementing complex interventions in CER. Disruptions due to COVID have created unanticipated challenges also requiring modifications. Recent methodologic standards for CER studies emphasize that fully characterizing modifications made is necessary to interpret and implement trial results. The purpose of this paper is to outline the modifications made to the OPTIMIZE trial using the framework for reporting adaptations and modifications to evidence-based interventions (FRAME) to characterize modifications to the OPTIMIZE trial in response to the COVID pandemic and other challenges encountered.
Methods The FRAME outlines a strategy to identify and report modifications to evidence-based interventions or implementation strategies, whether planned or unplanned. We use the FRAME to characterize the process used to modify aspects of the OPTIMIZE trial. Modifications were made to improve lower than anticipated rates of treatment initiation and COVID-related restrictions. Contextual modifications were made to permit telehealth delivery of treatments originally designed for in-person delivery. Training modifications were made with study personnel to provide more detailed information to potential participants, use motivational interviewing communication techniques to clarify potential participants motivation and possible barriers to initiating treatment, and to provide greater assistance with scheduling of assigned treatments.
Results Modifications were developed with input from the trial’s patient and stakeholder advisory panels. Goals of the modifications were to improve trial feasibility without compromising interventions’ core functions. Modifications were approved by the study funder and the trial steering committee.
Conclusions Full and transparent reporting of modifications to clinical trials, whether planned or unplanned, is critical for interpreting the trial’s eventual results and considering future implementation efforts.
Trial Registration: Clinicaltrials.gov NCT03859713, registered March 1, 2019
Uncertain Logistic population model with Allee effect
Authors: Gao Caiwen , Zhang Zhiqiang , Liu Baoliang
Published: November 2022

Any organism in nature will inevitably be affected by uncertain factors. The deterministic model and stochastic model are no longer suitable for population dynamics analysis under uncertain noise environment. In order to simulate these problems more reasonably, we propose an uncertain logistic population model with Allee effect, which describes the population dynamic behavior through uncertain differential equation. In this paper, the solution and Alpha-path of the uncertain Logistic population model with Allee effect are given, and the behavior analysis of the solution is also discussed. Besides, some numerical examples are put forward to illustrate the conclusions obtained in the paper.
Identification of a novel intronic variant of ATP6V0A2 in a Han-Chinese family with Cutis Laxa
Authors: Shu Jianbo , Zhang Ying , Zhao Yiran , Zhang Fang , Liu Yang , Cai Chunquan
Published: November 2022

Background: Cutis laxa is a connective tissue disease caused by abnormal synthesis or secretion of skin elastic fibers, leading to skin flabby and sagging in various body parts. It can be divided into congenital cutis laxa and acquired cutis laxa, and inherited cutis laxa syndromes is more common in clinic.
Methods: In this study, we reported a case of a Han-Chinese male newborn with ATP6V0A2 gene variant leading to cutis laxa. The proband was identified by whole-exome sequencing to determine the novel variant, and their parents were verified by sanger sequencing. Bioinformatics analysis and minigene assay were used to verify the effect of this variant on splicing function.
Results: The main manifestations of the proband are skin laxity, abnormal facial features, and enlargement of the anterior fontanelle. Whole-exome sequencing showed that the newborn carried a non-canonical splicing-site variant c.117+5G>T，p. (?) in ATP6V0A2 gene. Sanger sequencing showed that both parents of the proband carried the heterozygous variant. The results of bioinformatics analysis and minigene assay displayed that the variant site affected the splicing function of pre-mRNA of ATP6V0A2 gene.
Conclusions: In this study, it was identified that ATP6V0A2 gene c. 117+5G>T may be the cause of the disease. Few non-canonical splicing variants of ATP6V0A2 gene were reported in the past, and this variant expands the variants spectrum of the gene. The functional study of minigene assay plays a certain role in improving the evidence level of splicing variants, which lays a foundation for prenatal counseling and follow-up gene therapy.
Precise targeting for 3D cryo-correlative light and electron microscopy volume imaging of tissues using a FinderTOP
Authors: Sommerdijk Nico , de Beer Marit , Daviran Deniz , Roverts Rona , Rutten Luco , Sanchez Elena Macias , Metz Jurriaan , Akiva Anat
Published: November 2022

Cryo-correlative light and electron microscopy (cryoCLEM) is a powerful strategy to high resolution imaging in the unperturbed hydrated state, in particular for in combination with cryo-electron tomography (cryoET). In this approach fluorescence microscopy aids localizing the area of interest, and cryogenic focused ion beam/scanning electron microscopy (cryoFIB/SEM) allows preparation of thin cryo-lamellae for cryoET. However, the current method cannot be accurately applied on bulky (3D) samples such as tissues and organoids.
3D cryo-correlative imaging of large volumes is needed to close the resolution gap between cryo-light microscopy and cryoET, placing sub-nanometer observations in a larger biological context. Currently technological hurdles render 3D cryoCLEM an unexplored approach.
Here we demonstrate a cryoCLEM workflow for tissues, correlating 3D cryo-Airyscan confocal microscopy with 3D cryoFIB/SEM volume imaging. Accurate correlation is achieved by imprinting a FinderTOP pattern in the sample surface during high pressure freezing, and allows precise targeting for cryoFIB/SEM volume imaging and cryo-lift out for cryoTEM.
Institutional Integrity and Carbon Emissions
Authors: Khurana Ritika , Elbakidze Levan , Etienne Xiaoli
Published: November 2022

Institutions affect environmental quality by enabling economic growth, supporting environmental protection policies, and regulating industries. In this paper, we empirically examine the impact of institutions on carbon emissions. Using the Generalized Methods of Moments and an unbalanced panel of 120 countries from 1984 to 2016, we examine the impact of institutional integrity on per capita carbon emissions and carbon intensity of energy use. We also explore the heterogeneous effect of institutions on carbon emissions across income groups and regions. Lastly, we examine the impact of disaggregated institutional quality factors on carbon emissions. Our results confirm the presence of the Environmental Kuznets Curve in the models with and without institutions. However, the marginal effect of GDP per capita on carbon emissions is lower in the models that account for institutional integrity than the models that do not. Therefore, carbon policies should account for economic growth as well as institutional contexts. The results also show that although the combined institutional integrity is an important determinant of carbon emissions, individual institutional factors in isolation have minor effects.
Multiplicity of Zn coordination sites at cubic spinel ferrites: magnetism and influence of the Zn d band.
Authors: Tejera-Centeno Cesar , Rico Rubén , Gallego Silvia
Published: November 2022

Zinc substituted nickel ferrite (ZnxNi1 − xFe2O4) is investigated under density functional theory (DFT) within the DFT + U approximation for x ≤ 0.50, with particular interest in understanding the effect of Zn on the net magnetization. Using as a reference ZnFe2O4, the localization of the Zn d band is proved to have a large impact on the preference for Zn to occupy either tetrahedral (ZnA) or octahedral (ZnB) coordination sites, which in ZnFe2O4 is equivalent to the relative stability of the direct and inverse spinel forms. This affects the lattice volume and has important consequences on the magnetism of the system, as ZnA and ZnB alter the balance of interactions between magnetic sublattices in a different way. Our simulations support the presence of a significant ratio of Zn atoms at octahedral positions at ZnxNi1 − xFe2O4, mainly as the Zn concentration increases, putting limits to the ability to increase the magnetization of NiFe2O4 by Zn substitution.