bluuebunny/crossref_metadata_2025 huggingface dataset:
A Case Study on Karna Srava: Clinical Insights and Treatment Approaches
Authors: Santosh Kumar Shaw
Published: December 2024

Karna is an essential sensory organ associated with Shravana-hearing and is considered one of the Navadwaras, majorly influenced by the Akasha Mahabhuta. Acharya Sushruta has explained 28 ear diseases and Karnasrava is one among them. This article highlights the significance of local therapeutic interventions (Sthanika Chikitsopakramas) in the effective treatment of Karna Srava. A 34-year-old male patient visited the Shalakya Tantra Outpatient Department (OPD) at JJAMC, Aligarh, complaining of left ear pain for four days, along with itching. On examination, pus and fungal mass were found in the left ear canal and the tympanic membrane was not visible. The patient was treated using Karna Sthanika Chikitsopakramas, including Karna Prakshalana (ear irrigation) and Karna Dhupana (fumigation), along with Shaman aushadhis (internal medicines). These treatments resulted in complete recovery from the disease. The signs and symptoms seen in this case align with those of otomycosis, a fungal infection of the ear canal, which typically presents with pain, itching, discharge and ear blockage. Sincere immediate treatment of ear-related conditions is crucial due to the delicate nature of the ear and the importance of hearing. Early intervention helps to prevent complications and ensures early optimal recovery.
Indigenous foods of Tamil Nadu-A narrative review of its nutritive value and Mineral Bioavailability
Authors: Lakshmanakumar.V  , Arthi.G  , Rathinam.J
Published: December 2024

The Siddha system is one of the oldest traditional and holistic systems practiced in the southern part of India. “Food itself is Medicine and Medicine itself is Food” same indicates the Tamil quote “Unavae Marunthu, Marunthae Unavu” indigenous food is which is traditionally transferred from one generation to the next generation hence these food products are known as traditional foods. Indigenous food system helps to improve the quality of life. We conducted a literature search in scientific databases: PubMed and Google Scholar, also relevant Siddha literature from Dr. Ambedkar Library, Chennai. To identify studies reporting nutritive values and/or anti-nutrient content of IFs (not included in the Indian food composition database), consumed by peoples of Tamil Nadu. Data were selected and gathered from a total of 10 kinds of literature and 55 research papers. Some indigenous food displayed high levels of nutrients and minerals. Hence, efforts are desirable to encourage the inclusion of these nutritionally superior traditional foods into the usual diets. Indigenous food preparations are rich in nutraceutical compound which aids in better well-being and improve immunity. So, it is important to record indigenous foods in order to safeguard and maintain our traditional knowledge.
Molecular Docking Study of Boheco Desire (An Ayurvedic Proprietary Medicine)
Authors: Pankaj Kumar  , Neeraj Kumar Patel  , Harshad Jain  , Jahan Peston Jamas
Published: December 2024

BOHECO DESIRE is an Ayurvedic proprietary medicine formulated in capsule form, recommended for enhancing sexual health, libido, stamina, and energy. Objectives: This study aims to explore the molecular binding interactions of the major phytocompounds present in BOHECO DESIRE with a target protein and also to understand binding affinity and bioavailability, using advanced computational tools. Methodology: Molecular docking studies were performed using ChemDraw 20.1.1. Glide extra precision (XP) scoring tools were employed to calculate the docking scores. The binding energy of the receptor-phytoconstituent complexes was calculated using the Molecular Mechanics-Generalized Born Surface Area (MM-GBSA) method. Additionally, the QikProp module from Schrödinger was used to predict the ADME (Absorption, Distribution, Metabolism, Excretion) and physicochemical properties of the phytoconstituents. Results: Docking scores for L-DOPA, Cannabidiol, and Delta-9 Tetrahydrocannabinol suggest strong binding affinity with the target protein 1XOJ, with scores ranging from -9.4 to -4.1 kcal/mol. The van der Waals energy (Glide evdw) between -42.5 and -24.11 kcal/mol indicates favorable ligand-protein interactions. Glide energy, which includes van der Waals, electrostatic, and solvation energies, ranged from -45.07 to -26.53 kcal/mol, reinforcing the potential for stable complexes. Binding free energy values (-76.6 to -35.73 kcal/mol) suggest energetically favorable interactions. ADME predictions showed high oral absorption for Withanolide A, Delta-9 THC, and Cannabidiol, with the highest Caco-2 permeability for Delta-9 THC. Conclusion: The phytoconstituents demonstrated a strong binding affinity with 1XOJ with favorable ADME profiles. This indicates that BOHECO DESIRE's phytocompounds may have beneficial effects in sexual health.
Standardization of Siddha Herbal Formulation - Vaasathi Kashayam According to PLIM Guidelines
Authors: Preyadarsheni K  , Komalavalli T
Published: December 2024

Despite the fact that the global market for herbal and traditional medicines has surged, the rise in demand has brought about a threat for adulteration/substitution of raw drugs, clamoring consumers' faith into skepticism with the ensuing implications. To evaluate and avoid substandard herbal medicine manufacture, the Indian government has taken stringent measures, notably the establishment of PLIM (Pharmacopeial Laboratory of Indian Medicine - Protocol for testing AYUSH pharmaceuticals). The purpose of this research is the standardization of Siddha herbal decoction formulation 'Vaasathi kashyam' encompassing the leaves of Justicia adhatoda.L (Acanthaceae) and dry fruits of Vitis vinifera.L (Vitaceae) procured from the classic Siddha text 'Agathiyar 2000' specifically indicated for systemic hypertension (Raththa kothippu noi). The physicochemical parameters, phytochemical analysis, and powder microscopy of Vaasathi kashayam revealed an acidic pH and demonstrated the presence of phytochemicals such as tannins, phenols, terpenoids, alkaloids, flavonoids, and carbohydrates. HPTLC fingerprinting illustrates phytochemical spikes. Furthermore, the number of heavy metals, pesticide residues (organochlorine, organophosphorus and pyrethroids) and aflatoxins in VK was trace (BQL) or nonexistent, indicating its safety for therapeutic use. The total aerobic bacterial count and yeast/mold growth reported no growth/colonies, implying that the sample is free of aerobic microorganisms. Standardization of VK entailed authenticating along with evaluating the safety and quality of the prepared VK sample. These standardized characteristics could be deployed as a reference standard to guide subsequent VK qc evaluations.
The Role of Garbhini Paricharya in Prevention of Adverse Birth Outcomes
Authors: Nayana B
Published: December 2024

Garbhini Paricharya, or the care of a pregnant woman, is a vital aspect of Ayurvedic medicine that emphasizes the importance of holistic health during pregnancy. This traditional practice outlines guidelines for maternal care to ensure both the mother's and the child's well-being. The principles of Garbhini Paricharya highlight the interconnectedness of physical, mental, and emotional health, advocating for a nurturing environment during one of life’s most transformative periods. Adverse birth outcomes refer to negative results of pregnancy and childbirth, which can include preterm birth, low birth weight, stillbirth, and neonatal complications. Thus, the current review is based on the role of Garbhini Paricharya in the prevention of adverse birth outcomes.
Ayurveda in the Management of Amyotrophic Lateral Sclerosis
Authors: Unaisa N  , Manju P S  , Ambili Krishna
Published: December 2024

Amyotrophic lateral sclerosis (ALS) is the most common motor neuron disease and it is characterized by selective death of upper and lower motor neurons causing muscle atrophy, weakness and spasticity. As it is a fatal neurodegenerative disease, we can slow down the progression of symptoms through treatment. The present report deals with a case of ALS which can be correlated to Kapha avrutha vyana vata. Current paper is a case report of 47 year old female patient presented with the complaints of weakness and wasting of bilateral lower limb (Rt>Lt) since 20 years and weakness of bilateral upper limb (Rt>Lt) since 10 years and was diagnosed with progressive ALS. Aim of the study is to introduce an alternative therapeutic modality through Ayurveda which help to improve quality of life and delay the progress of disease. Patient had been treated with specific Panchakarma treatment modalities - Udwarthana, Acchasnehapana, Kukkudanda pinda sweda, Kayaseka, Mamsa pinda sweda, Musthadi Rajayapana vasti and specific Samana and Rasayana oushadis. The response of the patient’s condition to the treatment was assessed by ALSFRS -R Score. A substantial decrease in the intensity of symptoms was observed with a better quality of day to day activities. Thus, the treatment was found to be effective in managing the present ailment.
A Comparative Pharmaceutico-Analytical Study of Kaseesa Shodhana with Different Methods
Authors: Bhanderi Radhika  , Gohil Kunal M  , Kantariya Bhumi
Published: December 2024

Kaseesa is classified under two groups - Uparasa and Upadhatu. It is a mineral drug used in therapeutics. Hence Shodhana should be done before further use in as therapeutics or for preparation of Bhasama. The objective of this article is to compare pharmaceutical and Analytical aspects of Ashuddha Kaseesa and Shuddha Kaseesa (Sodhana with different methods). Material and Methods: Present study aimed to compare different Shodhana methods of Kaseesa which is by Bhavana in Bhringaraja Swarasa, Swedana in Bhringaraja Swarasa, Bhavana in Nimbu Swarasa and Bhavana in Citric acid solution rather than Nimbu Swarasa. The preliminary physico-chemical analysis was performed simultaneously for the Ashuddha and different samples of Shuddha Kaseesa (Shodhana by different methods). The total Iron contain and total inorganic contain were carried out by EW-XRF Spectroscopy technique. Results: After Shodhana with different methods average yield of Shuddha Kaseesa was 99.72%, 108.33%, 96% and 84% method A, B, C and D simultaneously. Total iron concentration of AK was 26.28. Significant physical changes have been observed after Shodhana. Which reflects in BBK, SBK, MNK and MCK has 23.52, 21.96, 26.6 and 41.46 percentage of total iron contain. Conclusion: Pharmceutico-analytical study revealed that there were major physical and chemical changes occurs after Shodhana in Kaseesa. Each method and liquid media led to major physical and chemical changes in Kaseesa. Which also reflects in total iron contain of Shuddha Kaseesa as compare to Ashuddha.
Knowledge, attitudes and readiness of final-year medical students towards clinical goals-of-care discussion
Authors: Ng Isaac Kah Siang , Goh Wilson Guo Wei , Thong Christopher Zi Yi , Tan Li Feng , Peh Chong Han , Chen Ken Xingyu , Goh Pamela , Teo Desmond B
Published: December 2024

In a rapidly ageing global population,1 there is increasing recognition of the importance of clinical goals-of-care (GOC) discussions aimed at understanding patients’ goals, wishes and care preferences in the event of serious illness or end-of-life situations,2 in order to affirm patient-centred decision-making, improve quality of life and facilitate their eventual transition towards end-of-life care.3,4 Examples of GOC discussions include informal advance care planning (ACP), legally-binding advance medical directives (AMD), inpatient code status discussions,2 and most recently, longitudinal serious illness conversations that improve patient prognostic awareness and psychological coping with advanced disease and end-of-life matters.
Enhancing care in nursing homes: Qualitative insights from the ENHANCE programme
Authors: Liew Yee Har , Yang Yingjia , Lim Sheryl Xin Yi , Lee Jean Mui Hua , Ong Chong Yau
Published: December 2024

Empower Nursing Homes And improve staNdards of CarE (ENHANCE) was a pilot programme introduced by Sengkang General Hospital to address the challenges faced by Singapore’s ageing population. With nearly 1 in 4 Singaporeans projected to be aged 65 years and above by 2030, the demand for effective long-term care solutions is increasingly urgent.1 The ageing population is a global phenomenon that results in increased healthcare expenditure.2 ENHANCE seeks to improve nursing home care and reduce preventable hospital admissions through collaboration with an acute hospital.3 The initiative aligns with the World Health Organization’s Integrated Care for Older People guidelines, focusing on preventive care and tailored interventions to improve elderly care in community settings.
Prevalence and causes of rifampicin-resistance genotypic/phenotypic discrepancy detected on Xpert MTB/RIF in Singapore
Authors: Choong Caroline Victoria , Galamay Lovel , Woo Jerlyn Huixian , Tey Angeline Jie-Yin , Chee Cynthia Bin Eng
Published: December 2024

The Xpert Mycobacterium tuberculosis/rifampicin (MTB/RIF) (Cepheid, Sunnyvale, CA, US) has been pivotal in tuberculosis (TB) diagnostics, enabling the rapid detection of both TB and RIF resistance. Xpert, a nucleic acid amplification test (NAAT), is recommended by both the World Health Organization (WHO)1 and Singapore’s clinical management guidelines2 as a frontline diagnostic tool for TB and RIF resistance. With a high specificity rate (98%) in detecting RIF resistance, Xpert has a positive predictive value (PPV) exceeding 90% in settings where the prevalence of RIF resistance is above 15%.3 However, in Singapore, a country with medium-incidence of TB and low prevalence of RIF resistance (<1% among individuals born in Singapore), 4 the PPV of detecting RIF resistance via Xpert is substantially lower.3 Phenotypic-genotypic discrepant RIF resistance have been reported to result from technical errors, false-positive results in paucibacillary samples,5 silent mutations6 or disputed mutations where minimal inhibitory concentrations (MICs) fall below critical concentrations in phenotypic drug susceptibility testing (pDST) systems.7 We conducted a quality assessment of sputum samples which tested positive for TB and RIF resistance using point-of-care Xpert at the Singapore National Tuberculosis Care Centre (NTBCC) to determine the prevalence and causes of false-positive RIF resistance.
Intrapleural fibrinolytic therapy for pleural infections: Outcomes from a cohort study
Authors: Yong Glenn Khai Wern , Wong Jonathan Jia Jun , Zhang Xiaoe , Tan Carmen Pei Sze , Wang Xiao Na , Quek Poh Seo , Yap Kim Hoong
Published: December 2024

Introduction: Pleural infections are a significant cause of mortality. Intrapleural fibrinolytic therapy (IPFT) utilising alteplase and dornase is a treatment option for patients unsuitable for surgery. The optimal dose of alteplase is unknown, and factors affecting treatment success in an Asian population are unclear. We sought to determine the factors affecting treatment success in Tan Tock Seng Hospital, Singapore and evaluate the efficacy of lower doses of IPFT.

Method: A retrospective analysis of patients with pleural infections treated with IPFT between July 2016 and November 2023 was performed. Treatment success was defined as survival without surgery at 3 months. Data, including patient demographics; comorbidities; RAPID (renal, age, purulence, infection source and dietary factor) scores; and radiological characteristics, were extracted from medical records and analysed. Linear mixed effects model and logistic regression were performed to determine factors affecting treatment success.

Results: A total of 131 cases were analysed. Of these, 51 (38.9%) reported positive pleural fluid culture, and the most common organism was Streptoccocus anginosus. Mean age was 65 years (standard deviation [SD] 15.5). Mean time from chest tube insertion to first dose of IPFT was 10.2 days (SD 11.5). Median starting dose of alteplase was 5 mg. Treatment success was reported in 112 cases (85.5%). There were no significant differences between the alteplase dose and radiological clearance. Patient age (odds ratio [OR] 0.94, confidence interval [CI] 0.89–0.98) and interval between chest tube insertion to first dose (OR 0.95, CI 0.91–0.99) were statistically significant variables for the treatment success.

Conclusion: Lower starting doses of alteplase remain effective in the treatment of pleural infection. Early IPFT may result in better outcomes.
OSMAN SAİB’İN KALEMİNDEN OSMANLI DEVLETİ’NİN SON DÖNEMİNDE CEZA SORUŞTURMASI
Authors: Ülker İbrahim , Aykanat Mehmet
Published: December 2024

Delillerin toplanması, şüphelinin belirlenmesi ve işlenen suçun niteliğinin tespit edilmesi açısından ceza soruşturması yargılamada önemli bir aşamadır. Bu aşamanın alanında uzman hukukçular tarafından yürütülmesi adalete ve hakkaniyete uygun bir sürecin işletilmesine katkı sunacaktır. Modern ceza hukuku uygulamalarında bu sürecin nasıl yönetileceği ve yapılacak işlemler hukuk kuralları ile düzenlenmiş ve işlemlerin ya bizzat hukukçular tarafından ya da hukukçuların gözetiminde yapılması sağlanmıştır.
Osmanlı Devleti, Tanzimat Dönemi ile birlikte ceza hukuku alanında da birtakım yeniliklere gitmiştir. Bunlardan biri de 1879 yılında kabul edilen Ceza Usul Kanunu’dur. Fransa’dan etkilenerek hazırlanan bu yasa ile soruşturma ve kovuşturma aşamaları ayrı ayrı düzenlenmiş ve soruşturma aşamasının savcı (müddeiumumi) ve sorgu hâkimi (müstantik) tarafından yürütülmesi hüküm altına alınmıştır. Masum kişilerin sonunda beraat edecek bile olsa belirli bir süre suç ithamı altında kalması önemli hak kayıplarına sebebiyet vermektedir. O nedenle bu sürecin hak kayıplarına sebebiyet vermeden gerçeği ortaya çıkarma hedefi ile yürütülmesi gerekmektedir. 1879 Ceza Usul Kanunu’nun bu hassasiyetle hazırlandığını söylemek mümkündür.
Kâğıt üzerinde mükemmel yasalar yapmak mümkündür. Ancak yasaların hazırlanmasından belki daha önemli olan bu yasaların nasıl uygulandığıdır. 1879 Ceza Usul Kanunu’nun nasıl uygulandığı, devrin önemli hukukçularından ve kendisi de bir sorgu hâkimi olan Osman Saib’in “Tahkikat-ı Evveliye ve İstintakiye” isimli çalışması esas alınarak bu makale ile ortaya konulmaya çalışılmıştır.
The Effect of Spraying Calcium Nano Fertilizer and Humic Acid on the Growth and Yield of Cauliflower Crop in Calcareous Soils
Authors:   Department of microbiology, college of science, Al-Karkh University of science, Iraq, Ali Hanan Abdullah , Taaban Sadik Kadhim ,   Corporation of Research and Industrial Development, Ministry of industry and minerals, Iraq, Challoob Walaa Salah ,   College of science, Al-Karkh University of science, Iraq
Published: December 2024

This research aims to demonstrate the effect of using nano-fertilizer (calcium oxide) on the growth of cauliflower at concentrations (0, 100, 200) ppm and humic acid in concentrations (0, 2, 4) ml .l-1 and its effect in growth and yield of cauliflower crop (plant height, disc weight, and total yield) also (diameter of disc, leaf area, fresh leaf weight) and study this effects in calcareous conditions in calcareous soil. The results showed the superiority of the treatment (H2+Ca200) in terms of its impact togather on the studied treatments, as it achieved the best results, which reached 47.18 cm, 0.97 kg, 40.95 T.ha-1, 24.60 cm, 284.33cm2, 0.99 kg respectively, There were significant differences between the studied treatments, and the experiment showed the possibility of using a combination of foliar fertilization of both organic humic acid and nano-calcium fertilizer in achieving the best growth and production rates for cauliflower plant yield.
Analysis of the Implementation of Minimum Service Standards (MSS) in Emergency Installation of Priscilla Medical Center Hospital
Authors:   Universitas Adhirajasa Reswara Sanjaya, Karera Anggita Dian , Purwadhi Purwadhi ,   Universitas Adhirajasa Reswara Sanjaya, Wahyudi Bayu ,   Universitas Adhirajasa Reswara Sanjaya, Andriani Rian ,   Universitas Adhirajasa Reswara Sanjaya
Published: December 2024

The achievement of the Minimum Service Standards (MSS) indicators in the Emergency Department of the Hospital is still not optimal so that the services provided are not as expected. This study aims to explore the situation related to the input, process, and output of the implementation of MSS for emergency services at Priscilla Medical Center Hospital. This study uses a qualitative design with a case study approach. The research time is from September to November 2023 at the Emergency Department of Priscilla Medical Center Hospital. Data collection techniques are carried out through in-depth interviews, forum group discussion (FGDs), and document reviews. The results of the study indicate that the quality indicator policy at Priscilla Medical Center Hospital does not cover all MSS indicators, the quality of human resources is good but the number of general practitioners is not sufficient, facilities and infrastructure are not fully in accordance with standards, and monitoring and evaluation has not been running well. Planning, organizing, implementing and controlling the implementation of MSS in the Emergency Department of Priscilla Medical Center Hospital has not been optimal. The output results show that patient mortality ≤24 hours is still high.
Clinical Application of Autologous Fat Graft and Dermis-Fat Graft in Patients with Cleft Lip and Palate Deformities: A Case Series
Authors:   Medical Doctor, Faculty of Medicine Udayana University, Denpasar, Bali, Indonesia, Claudia Grace , Utami Putu Trisna ,   Plastic Surgeon, Department of Plastic Reconstructive and Aesthetic Surgery, Bali Mandara General Hospital, Denpasar, Bali, Indonesia
Published: December 2024

Cleft lip and palate patients require multiple surgeries from childhood to adulthood to improve both function and aesthetics. Primary surgery may not completely resolve a cleft, residual scarring, asymmetry, nose deformity, or palatal fistula, can sometimes remain, leading to insecurity and social withdrawal. This study reports five cases of patients aged 7-13 years old with prior cleft lip and palate surgeries, treated with autologous materials for lip, nasal, or palatal repair, based on individual needs at Bali Mandara General Hospital, Denpasar, Bali, Indonesia. The first two patients had functional lips but were dissatisfied with scars and poor lip contour. Treatments included dermis-fat grafts, fat transfer injections, and/or scar revision. The third and fourth patients had Pittsburgh Type V palatal fistulas with nasal leakage and hypernasal speech, managed with dermis-fat grafts to close the fistulas. The fifth patient had a nasal deformity due to absent of primary correction and underwent nasal dorsal augmentation with a dermis-fat graft. All patients expressed improved appearance, function, and confidence postoperatively, with no complications during follow-up. Autologous materials such as autologous fat grafting and dermis-fat are reliable, versatile approach, and cost effective for improving lip contour, closing oronasal fistulas, and correcting nasal deformity.
Epidemiology of Burn Patients at Bali Mandara General Hospital Treated With Emergency Management of Severe Burns Protocol: A Retrospective Study
Authors:   Medical Doctor, Faculty of Medicine Udayana University, Denpasar, Bali, Indonesia, Claudia Grace , Utami Putu Trisna ,   Plastic Surgeon, Department of Plastic Reconstructive and Aesthetic Surgery, Bali Mandara Regional Public Hospital, Denpasar, Bali, Indonesia
Published: December 2024

Background Burns are one of the most common injuries resulting from heat or radiation, electricity, and chemicals. Bali Mandara General Hospital is a new government hospital operated in October 2017. The hospital implemented the Ministry of Health Regulation’s Guideline which applies the Emergency Management of Severe Burns to manage burns cases.

Aim The current study aims to determine the epidemiological burn patients at Bali Mandara General Hospital, and emphasize the importance of burn management strategies.

Methods A hospital-based, single-center, and retrospective study was conducted from November 1st, 2017 to June 30th, 2022 at Bali Mandara General Hospital. Demographic and clinical information were extracted from hospital medical records. Data is collected and analyzed using Microsoft Office Excel and SPSS Statistic version 26. Correlation between ABSI score and length of hospital stay were examined.

Results A total of 142 burn patients were included in this study; including 56 (39,43%) moderate – severe burn patients, 35 (62.50%) are male and 21 (37.50%) female, out of which are 33 (82.5%) patients with burn time-admission gap < 24 hours. The major proportion of burn patients are adults (18-65 years old) - 110 (77.46%) patients with an average age of 27±17.72 years. The most common total body surface area (TBSA) of burn ranged from 1 to 10%. The major proportion of moderate – severe burn patients are adults (42 patients, 38.18%). There were 40 (71.42%) patients undergoing surgical procedure. Scald and flame contributed equally for the amount of moderate to severe burns (21 patients, 37.50%). Average length of hospital stay was 8.3 days, ranging from 3 to 15 days. Seventeen (42.50%) patients have low mortality risk. Spearman’s correlation between ABSI score and length of stay resulted in a coefficient of 0.48, indicating a moderate correlation.

Conclusion Scald is the most common cause of burn injury in all burn patients and male dominated in this study. ABSI score and length of stay has positive correlation in our study.
Retrospective Study of Maxillofacial Traumatic Injury Pattern on Plastic Surgery Unit at Bali Mandara General Hospital
Authors:   Medical Doctor, Faculty of Medicine Udayana University, Denpasar, Bali, Indonesia, Claudia Grace , Utami Putu Trisna ,   Plastic Surgeon, Department of Plastic Reconstructive and Aesthetic Surgery, Bali Mandara Regional Public Hospital, Denpasar, Bali, Indonesia
Published: December 2024

Introduction Trauma is a major cause of morbidity and mortality, often accompanied by maxillofacial injuries in a significant portion of patients. Maxillofacial trauma represents a serious public health problem and their epidemiology varies between populations. Bali Mandara General Hospital is a new government hospital operated in October 2017, that provides care for plastic surgery patients, including maxillofacial trauma patients. The current study aims to investigate the pattern of maxillofacial traumatic injuries, and management of maxillofacial traumatic injuries by our plastic surgery service.

Methods A hospital-based, single-centered study was conducted from January 1st, 2018 to December 31st, 2022 at Bali Mandara General Hospital. Medical records of maxillofacial patients undergoing surgical procedure were retrospectively reviewed Data is collected and analyzed using Microsoft Office Excel and SPSS Statistic version 26.

Results A total of 107 maxillofacial patients who received treatment for maxillofacial trauma in the departments during the study period were included; 76 (71.02%) are male and 31 (28.97%) female. The majority of patients belonged to the 21-30 years age group (27 patients, 25.23%). The mean age for the group was 32.26±17.31 years, ranging from 1 to 83 years. Soft tissue injuries (64; 29.63%) and maxilla fracture (35; 16.20%) were the two most common site of maxillofacial injuries. The most common associated injuries was upper extremity injuries (11; 30.56%), followed by lower extremity injuries (9; 25.00%). The most common surgical management were ORIF (61; 28.64%) and debridement (54; 25.35%).

Conclusion Young age and males were predominantly affected. Maxillary fracture was the most frequent maxillofacial fracture. Maxillofacial trauma was often associated with upper extremity injuries. ORIF was the most surgical common management.
The Impact of Gut Microbiota on Liver Diseases: Insights into Pathophysiology, Diagnosis, and Emerging Therapeutic Approaches
Authors:   Instituto Mexicano del Seguro Social Hospital General Regional 2 El Marqués. Querétaro, México., Cervantes Yafte Soto , Avendaño Ana Laura Esmeralda Muñoz ,   U.M.A.E. Hospital de especialidades C.M.N. GRAL. "Manuel Avila Camacho" Instituto Mexicano del Seguro Social Puebla, México., Moreno Michelle Macias ,   Universidad de las Américas Puebla. Puebla. México.
Published: December 2024

The gut microbiota plays a pivotal role in maintaining metabolic homeostasis and immune regulation, with its dysregulation increasingly recognized as a critical factor in the pathogenesis of liver diseases. This review explores the intricate interplay between gut microbial composition and liver health, focusing on the gut-liver axis as a key mediator. The disruption of gut barrier integrity and subsequent translocation of microbial products, such as lipopolysaccharides and short-chain fatty acids, contribute to the progression of liver disorders, including non-alcoholic fatty liver disease (NAFLD), alcoholic liver disease (ALD), and cirrhosis. The review also examines the implications of microbial dysbiosis in liver inflammation, fibrosis, and hepatocarcinogenesis, highlighting the diagnostic potential of microbiota profiling and biomarkers. Finally, emerging therapeutic strategies, such as probiotics, prebiotics, fecal microbiota transplantation, and precision microbiome editing, are discussed as promising avenues for intervention. Understanding the bidirectional relationship between the gut microbiota and the liver offers novel insights into disease mechanisms and opens the door for innovative therapeutic approaches in hepatology.
Determination of Antidiabetic Activity of Ethanolic Extract of Karas Tulang Leaves (Chloranthus Erectus) In Alloxan-Induced Wistar Rats
Authors:   Pharmacy Study Program, Faculty of Pharmacy, Muhammadiyah University of Surakarta, Musayyaf Ahmad Farras , Haryoto Haryoto ,   Pharmacy Study Program, Faculty of Pharmacy, Muhammadiyah University of Surakarta
Published: December 2024

Diabetes mellitus is a chronic condition that affects the metabolism of carbohydrates (glucose) in the body. According to data from the 2018 Basic Health Research (Riskesdas), there was a 2.1% increase in the prevalence of diabetes mellitus in Indonesia. The objectives of this study are: 1) To determine the antidiabetic activity of ethanol extract from Karas Tulang leaves in Wistar strain rats modeled for diabetes mellitus induced by alloxan, and 2) To perform phytochemical screening of the ethanol extract of Karas Tulang leaves (Chloranthus erectus).The research method utilized an experimental design with four groups of Wistar strain white rats. The phytochemical screening conducted included tests for alkaloids, saponins, flavonoids, and tannins using the thin-layer chromatography (TLC) method. Based on the results of the phytochemical screening tests, it was found that Karas Tulang leaves contain alkaloids, saponins, flavonoids, and tannins. The effectiveness of the antidiabetic activity was analyzed using SPSS through statistical tests, including normality, homogeneity, Kruskal-Wallis, and Mann-Whitney tests. Based on the statistical test results, it was concluded that the ethanol extract of Karas Tulang leaves at doses of 50 and 100 mg/kgBW is effective in reducing blood glucose levels.
Campaigning in the Age of AI: Ethical Dilemmas and Practical Solutions for The UK and US
Authors:   Department of Political Science, Obafemi Awolowo University Ile-Ife, Adebayo, ANYA Anya
Published: December 2024

The increasing integration of Artificial Intelligence (AI) in political campaigns has introduced significant advancements in voter engagement and campaign strategies, particularly in the United Kingdom and the United States. However, this development also raises complex ethical concerns that challenge the integrity of democratic processes. This study examines the implications of AI in political campaigns, focusing on its applications in micro-targeting, AI-generated content, and voter behavior analysis. Drawing on case studies from the Brexit referendum and U.S. presidential elections, the analysis highlights how AI has been leveraged to enhance campaign efficiency through data-driven targeting and personalized messaging. While these technologies have revolutionized political communication, they also present ethical challenges, including manipulation, privacy violations, and accountability. Findings indicate that AI-generated content, such as tailored ads and deepfakes, risks misleading voters and amplifying biases, thereby eroding trust in political messaging. Privacy concerns also emerge from the extensive use of voter data, often collected without explicit consent, raising questions about transparency and ethical boundaries. Additionally, the lack of accountability for AI-driven misinformation further undermines public confidence in electoral processes. The study underscores the urgent need for comprehensive regulatory frameworks and ethical guidelines to ensure the responsible use of AI in political campaigns. By addressing these concerns, stakeholders can safeguard democratic values while harnessing the benefits of AI for transparent and equitable political engagement. This research contributes to ongoing debates about the role of AI in shaping modern political landscapes and emphasizes the imperative of ethical oversight.
Analysis of Factors Affecting Labor Productivity in Perum Bulog in West Nusa Tenggara Province
Authors:   Faculty of Economic and Business, University of Mataram, Indonesia, Safitri Baiq Zigrina , Maryam St. ,   Faculty of Economic and Business, University of Mataram, Indonesia
Published: December 2024

This study aims to analyze the factors that affect labor productivity in Perum Bulog in West Nusa Tenggara Province. The variables studied include work experience, wages, and age. The research method used is multiple linear regression analysis with data collected using questionnaire instruments. The results of the study showed that work experience, gender, and wages had a positive and significant effect on labor absorption, while age had a negative and significant effect. The value of the determination coefficient (R²) of 0.684 shows that 68.4% of the variability of labor productivity can be explained by the four independent variables. This study concludes that an increase in wages and job openings can increase labor productivity, while an increase in age tends to reduce labor productivity in Perum Bulog West Nusa Tenggara.
The Role of the Department of Industry and Labor of Surabaya City in Handling Labor Complaints in Industrial Companies
Authors:   Universitas Pembangunan Nasional Veteran Jawa Timur, Aditia Yuli Indra , Hariyana Nanik ,   Universitas Pembangunan Nasional Veteran Jawa Timur
Published: December 2024

This research examines the role of the Surabaya City Department of Industry and Manpower in handling labor complaints in industrial companies, with a focus on the dispute resolution process. With a qualitative approach, this research explores the mediation process facilitated by the department, particularly in cases of unilateral termination of employment (layoffs). The findings show that mediation is effective in achieving peaceful resolutions, avoiding litigation, and ensuring fair outcomes for both workers and employers. The identified constraints include incomplete documentation, absence in mediation, and differences in legal interpretation, which prolong the resolution process. This research highlights the importance of improving documentation systems, raising stakeholder awareness, and developing mediator competencies. This research provides insights into the effectiveness of government intervention in maintaining harmonious industrial relations and suggests practical steps to improve mediation practices
Possibilities of Using Proteolytic Enzymes Carica Papaya L in Medical Practice
Authors:   Turkmen State Institute of Architecture and Civil Engineering, Turkmenistan, AM Penjiyev
Published: December 2024

The aim of this study is to investigate the proteolytic enzymes of the melon tree (Carica papaya L), grown in a solar greenhouse in Turkmenistan, to study
the potential of these enzymes in medical practice.
Proteolytic enzymes of plant origin are contained in the milky juice of the melon tree (Carica papaya L.) These are papain, chymopapain A and B, peptidases
A and B. Lekozyme , caripazim , lysozyme and many other drugs widely used in medical practice are produced from these proteolytic enzymes . We have
experience in using proteolytic enzymes obtained from the milky juice of the melon tree in surgery (for purulent wounds, phlegmon and abscesses of the
upper and lower extremities, purulent mastitis, trophic ulcers of the feet) and dentistry (for ulcerative gingivitis, periodontitis, etc.). Taking into account
the encouraging results obtained, we plan to conduct research work on the treatment of urological diseases using various proteolytic enzymes obtained
from the milky juice of the melon tree grown in local conditions of Turkmenistan.
The obtained solution from papaya allows to reduce the treatment time of purulent infections of soft tissues and oral cavity, which in turn is important for
timely prevention of occurrence of abscesses and other complications. Agricultural technology of cultivation possibilities and technology of obtaining
proteolytic enzymes from leaves and fruits of melon tree in conditions of Turkmenistan have been developed. Microclimate based on renewable energy
sources has been created for cultivation.
Conclusion: The advantage of the claimed remedy compared to known ones is that the treatment uses the organic, natural composition of the plant’s
substances, which has effective properties in the treatment of inflammatory diseases and wounds.
Processos de referenciação meta na divulgação da ciência: abordagem argumentativa
Authors: Palumbo Renata
Published: December 2024

Neste trabalho, comparamos um roteiro escrito e sua retextualização em podcast de um Trabalho de Conclusão de Curso de uma estudante de Linguagens em 2022. Nossa finalidade correspondeu à identificação de como ocorre a passagem de um a outro e à análise de como a referenciação meta colabora para a operacionalização do projeto argumentativo. Identificamos as modificações realizadas na versão final e buscamos classificar tipos de referenciação meta do ponto de vista da argumentação. Embasamo-nos em pesquisas sobre a referenciação (Jubran, 2009; Morato, 2012) e em estudos que se dedicaram à argumentação (Charaudeau, 2016b; Perelman e Olbrechts-Tyteca (2002[1958]). Nossas análises permitem afirmar que a referenciação meta cumpriu papel argumentativo por ter sido mobilizada para adequar o texto para um contexto interlocutivo que abarca públicos especialistas e não especialistas, de modo a criar condições para fazer entender, fazer crer e fazer participar.
Clube de argumentação no IFRN Câmpus Ipanguaçu
Authors: Martins Wíliton José De Araújo , Costa Elis Betânia Guedes da
Published: December 2024

O presente trabalho relata uma experiência no âmbito do projeto de extensão Argumentação e cidadandia do IFRN Campus Ipanguaçu ao longo de 2023. Tal projeto objetivou aproximar estudantes do universo da argumentação, engajando-os em atividades de leitura e produção de textos. Para isso, buscou-se respaldo teórico em autores como Charaudeau (2020), Emediato (2004), Fiorin (2016) e Koch (2011), os quais apresentam direcionamentos acerca da argumentação e de suas formas de expressão. As atividades foram organizadas em três fases bem demarcadas: formação teórica; prática de leitura e produção textual; e intervenção externa. De forma geral, ao longo da extensão, o grupo mostrou-se assíduo, participativo e competente na elaboração e recepção de textos.
La mentalidad conspirativa como dispositivo cognitivo en la construcción discursiva del regreso de Perón (1973)
Authors: Romero Facundo Exequiel
Published: December 2024

Este artículo presenta un análisis retórico-discursivo de la mentalidad conspirativa como dispositivo cognitivo en la construcción discursiva del regreso de Perón en 1973 como acontecimiento en la prensa de tipo comercial, de tipo político y en los servicios de inteligencia. El análisis indaga diferentes campos del discurso social en vistas a identificar regularidades propias de una hegemonía discursiva. Como resultado, se constató un modo de razonar conspirativo que atraviesa diferentes materialidades discursivas. Dicho dispositivo cognitivo aparece relacionado con operaciones lingüísticas: la modalidad de enunciación interrogativa, el uso de conectores adversativos en relación con las pruebas, la fotografía como índice, las fuentes textuales oficiosas pasivas, la amalgama y la desmitificación en tanto técnica polémica. El trabajo aporta al conocimiento sobre la construcción del regreso de Perón como acontecimiento y a las conceptualizaciones de la mentalidad conspirativa en relación con operaciones enunciativas y argumentativas.
Toadas dos bois-bumbás de Parintins: estratégia para reflexões sobre as queimadas na Amazônia, por meio da educação intercultural e ambiental
Authors: Lima Adriane , Antunes Ettore Paredes
Published: December 2024

Este artigo investiga como a educação intercultural pode fomentar a reflexão sobre os problemas ambientais das queimadas na Amazônia, utilizando as toadas dos Bois-bumbás de Parintins como estratégia pedagógica. A pesquisa adota uma abordagem qualitativa e inclui a integração da educação intercultural com a educação ambiental e o ensino de química. A estratégia envolveu a apresentação de algumas toadas dos bois Caprichoso e Garantido, que enfatizam questões ambientais, para em seguida serem estabelecidas conexões com os conteúdos científicos. Os resultados dessa abordagem mostram que a utilização das toadas, que já abordaram questões ambientais em suas letras, permitiu que os estudantes estabelecessem ligações entre os problemas das queimadas e o conteúdo de química. Esse resultado reforça a importância de uma abordagem pedagógica que valorize o conhecimento tradicional e local, proporcionando uma educação que não apenas informa, mas também transforma, promovendo o pensamento crítico e a conscientização ambiental alinhando conhecimentos culturais e científicos.
Pair distribution function analysis for Pt-Pd-Co atomic mobility in nanoparticles
Authors: Hernandez Guillermo , Araiza Ibarra José de Jesús , Vargas Téllez Jorge Alberto
Published: December 2024

Through the in-situ monitoring of fuel cells in oxidation-reduction processes with ternary nanoparticles (Pt-Pd-Co), the Pair Distribution Function (PDF) is created by the Fourier transform of the high-energy X-ray diffraction pattern of the sample. Lattice deformations in nanostructures have been shown to be reflected in the oscillation of the peaks of the atomic PDF. Analyses have revealed that there is atomic mobility within the nanoparticles. Thus, in this work we study the effect on PDF of different internal variables for nanoparticles modeled based on data from a previous interdisciplinary study by a third party, the variables include temperature, vacancies and atomic species distribution. Several atomic structural models were created, and molecular dynamics simulations were applied to them using LAMMPS and the Modified Embedded Atom Method (MEAM) for the atomic interaction. The PDF’s generated from the models were compared to experimental data and the best match was identified. It is shown that a non-uniform distribution of the elements of the ternary system within the structures is the cause of the lattice strain oscillations for the nanostructures, mainly the radial distribution of Co turns out to have a greater effect on the peaks of interest in the PDF altering the general structure of the nanoparticles.
A risk-based approach (thinking) based on the example of a medical organization
Authors:   Academy of Labor and Social Relations, Efimenkova Anastasia D. , Bychkov Vladislav Ya. ,   Academy of Labor and Social Relations
Published: December 2024

The article examines the mechanism of implementing a risk-based approach (thinking) in
medical organizations. The possibilities of its application in the case of transition to various management models, including the use of lean manufacturing technologies, are presented. The analysis of theoretical and practical issues of the implementation of this concept, as one of the methods for improving productivity and improving the safety of the medical sector, is carried out. The relevance of the study is due to the need to improve the level of corporate, technological and intellectual potentials of the healthcare sector in our country. The purpose of the study is to study the experience of introducing a risk-based approach (thinking) into the work structure of medical organizations. As a result of the research, a review of scientific and practical literature was carried out, author's conclusions and proposals for the modernization of the quality and safety assurance system of medical organizations were given. A risk management model in a medical
organization has been compiled as part of the implementation of a risk-based (thinking) approach.
The research on consumer preferences, expectations and emotions in the real estate market in 2024
Authors:   Ural Federal University named after the first President of Russia B. N. Yeltsin, Zaikov Artem A. , Danilova Ksenia A. ,   Ural Federal University named after the first President of Russia B. N. Yeltsin
Published: December 2024

The gap in supply and demand in the real estate market, which is characterized by a significant
share of unclaimed finished products, necessitates research on consumer preferences and expectations. To successfully conduct marketing campaigns, developers need to pay attention not only to the unique characteristics of their own product, but also to the emotional background and feelings of the buyer that arise during the process of selection, expectation and operation. The article presents the advantages and disadvantages of purchasing housing in new buildings as perceived by consumers, and also contains an analysis of the satisfaction of residential property owners with the choice they made and the accompanying service they received. There are recommendations, based on the identified expectations, emotions and concerns of consumers, for the formation of effective marketing strategies for product promotion by developers throughout the entire buyer's journey.
Problems of environmental control and ways to solve them at the present stage of society development
Authors:   Academy of Labor and Social Relations, Klyukin Evgeny V. , Bychkov Vladislav Ya. ,   Academy of Labor and Social Relations
Published: December 2024

The article discusses the problems of environmental control and the ways to solve them at the
present time. In this work, an analytical review of the main environmental problems of the present time is carried out, as well as the key dangers and challenges that they pose to the ecological and economic progress of the national scale are identified. The authors explore and propose strategies to neutralize these threats. The paper examines in detail the potential negative consequences for the environmental wellbeing of the country, emphasizes the need for an integrated approach to solving the problem, including the interaction of various risks. The analysis shows that the current system of state regulation in the field of ecology, technological development of the economy, legislation in the field of ecology and other elements of the institutional environment in Russia require significant changes to effectively respond to environmental challenges. A review of scientific research on the presented topic is made, the author's conclusions are given.