bluuebunny/crossref_metadata_2025 huggingface dataset:
Fundamentos de Geografía Económica y movilidad logística aplicados al turismo
Authors: Calderón-Fajardo Víctor , Para González Lorena
Published: November 2023

En el primer capítulo se abordan muchos de los fundamentos principales que configuran la geografía económica. Cobra especial relevancia la adaptación de conceptos con ejemplos al contexto turístico. Se tratan los sistemas de producción e intercambio en el surgimiento de las ciudades, la localización empresarial, los atributos y particularidades del clúster y el distrito industrial, además del síndrome holandés, el fenómeno de la gentrificación, los patrones de consumo, las decisiones de producción y los modelos organizativos de producción en las empresas globales. Finalmente, el capítulo se cierra con el concepto de innovación, la propensión que tienen los entornos innovadores, y con un ejemplo sobre la capacidad innovadora según el Regional Innovation Scoreboard. En el segundo capítulo se tratan las consideraciones que engloban el plan logístico de una empresa, con especial atención a las particularidades de la industria turística. Por ello, se hace hincapié en la tipología de los proveedores, los criterios para su elección, el carácter multifuncional de los stocks, la distribución física y comercial o los factores decisivos para utilizar un medio para el transporte de productos. Igualmente, sobre las fases del proceso de integración de la cadena logística, con el caso concreto sobre Renfe e Iberia. Se utiliza el ejemplo de la modalidad del autoservicio para hablar sobre las decisiones estructurales e infraestructurales, el sistema pull y la modularidad en un restaurante. También se enfoca en los elementos del lean facturing en el autoservicio, además de los indicadores básicos para una evaluación y las técnicas principales para ahorrar costes. Las tipologías de plataformas logísticas aplicadas al sector turístico también cobran relevancia, además de los conceptos como e-fulfillment y e-procurement y la logística inversa. El capítulo finaliza con ejemplos y casos concretos aplicados a un hotel que pasan por su evaluación como empresa red, los desafíos de gestión, la implementación del sello Q de calidad, entre otros. El libro se cierra con las políticas de gestión y análisis de los flujos turísticos con el ejemplo de la cala Macarella, en Menorca.
Impacts of agroforestry practices on the physico-chemical, water and soil fertility properties in semi-arid environments: The case of Bordjias Plain (Mesra, North-West Algeria)
Authors: Dalila Fettouch , Ibrahim Berkane , Houari Boulenouar , Mohamed Larid
Published: November 2023

All problems related to conventional agriculture are a reference to the search for sustainable solutions. In this context, a comparative study between three agroforestry practices (AFP): Citrus sinensis, Olea europaea, and Punica granatum, each associated with Vicia faba (Fabaceae), was conducted on Bordjias Plain. In order to study the impacts of each association on the physico-chemical properties and water and soil fertility, the soil samples were taken from two profiles (P1 under the tree and P2 between trees), through three horizons (Sh, Mh and Lh), before and after the establishment of culture. The results of the analyses show that moisture variability appears to be influenced by the type of soil and the woody species. By increasing the organic matter content, these associations improve the structural stability of the soil, accelerating the process of dissolution of calcium carbonate, changing the pH, EC, P2O5, CEC, and ion exchange in soil. The statistical approach (ANOVA) allowed us to bring out the positive impact of agroforestry practices on soil fertility.
Lactic acid bacteria (Leuconostoc mesenteroides) as bioprotective agents against some pathogenic fungi in common bean
Authors: Djelilate Mohamed , Mansouri Lahouaria Mounia , Mami Anas , Kheloufi Abdenour
Published: November 2023

The common bean (Phaseolus vulgaris L.) is the most important edible food legume in the world. However, its cultivation encounters several phytopathogens. Our study aims to improve food quality and safety through more natural protection methods such as the use of microorganisms that allows us to avoid and minimize pesticide risks. For this purpose, we tested the antagonistic capacity of lactic acid bacteria isolated from raw goat’s milk against four fungal strains isolated from P. vulgaris var. djedida. In this study, lactic acid bacteria (LAB) (Leuconostoc mesenteroides) were screened in vitro for antifungal activity at 28 °C against Fusarium oxysporum, Botrytis cinerea, Aspergillus flavus, and Alternaria alternata. The statistical analysis of the antifungal activity of LAB showed significant differences after a seven-day period. The results of the direct confrontation on the PDA (Potato Dextrose Agar) and MRS (de Man, Rogosa, and Sharpe) Agar medium showed better inhibition by the lactic acid strain on MRS Agar medium. L. mesenteroides gave the highest inhibition rate of 57.6% for the pathogen B. cinerea and 29.1%, 33.3%, and 26.7%, respectively, for the pathogens A. alternata, B. cinerea, F. oxysporum, and A. flavus on the solid PDA medium. However, on the MRS Agar medium, inhibition rates of 88.1% and 80.5% were observed for the pathogens B. cinerea and A. flavus and a total inhibition of 100% on A. alternata and F. oxysporum in the presence of the strain L. mesenteroides. This study led to suggest that food-derived LAB strains could be selected for biotechnological application to control phytopathogenic fungi.
Effect of salinity on the germination of three species of the Acacia genus (A. karroo, A. saligna, and A. tortilis)
Authors: Kheloufi Abdenour , Mansouri Lahouaria Mounia , Meradsi Fouad
Published: November 2023

This scientific paper explores the impact of soil salinity on plant growth, with a particular focus on the relationship between salt tolerance and seed germination. To investigate this, three species of Acacia (Fabaceae), namely A. karroo, A. saligna, and A. tortilis, were selected, and their seeds were collected from Algeria. To overcome seed coat inhibition, seeds were treated with concentrated sulphuric acid, followed by a wash with distilled water before being sown in a culture medium containing varying concentrations of salt, specifically sodium chloride (NaCl) ranging from 0 to 600 mM. The germination tests were conducted over a 21-day period, with measurements taken at intervals of three days, and both the final germination percentage (FGP) and mean germination time (MGT) were calculated. The results showed that at 600 mM NaCl concentration no germination occurred during the experiment. The germination rates exhibited three phases, an initial latency phase, a second exponential phase of accelerated germination, and a third plateau phase. A. karroo seeds demonstrated the highest salt tolerance, germinating under high salinity conditions of 400 mM NaCl, with a FGP of 66%. In contrast, A. tortilis showed significantly lower salt tolerance, with only 20% germination at the same concentration. A. saligna had the lowest salt tolerance, with germination only occurring under 150 mM NaCl concentration and with a FGP of only 18%. Based on these findings, the rank order of the studied species in terms of decreasing tolerance to high salinity conditions, as determined by their respective germination capacities, is as follows: A. karroo > A. tortilis > A. saligna. Although A. saligna was the most sensitive species, it was still categorized as a salt-tolerant glycophyte. Overall, this study provides valuable insights into the impact of salt stress on Acacia species and could contribute to the development of salt-tolerant crops in the future.
Evaluation of the aphicidal activity of Salvia microphylla (Lamiaceae) aqueous extracts against Aphis pomi (Aphididae)
Authors: Benhizia Toufik , Lebbal Salim , Zeraib Azzeddine , Hasrouri Bilal , Messaoudia Youcef Alamine , Ziani Ammar
Published: November 2023

The aphid Aphis pomi represents an important pest of apples. The use of botanical extracts may be a safe and effective way to control this pest. In this context, we studied the aphicidal and repellent effects of aqueous extracts of Salvia microphylla against A. pomi. Five concentrations were tested on two main aphid parameters: mortality rate and percentage of repellency. The results showed that concentrations of 10% recorded the highest mortality rate (73.33%) and percentage of repellency (62.59%). After further field investigations, the use of S. microphylla may constitute a component of the integrated management of aphids.
Evaluation of the ‘Leányka’ (‘Fetească Albă’) white wine grape variety’s qualitative and quantitative parameters in the context of different bud loads
Authors: Balla Géza , Lunka Tekla Amália , Szekely-Varga Zsolt , Moldován Csaba , Kendi Csongor , Kentelky Endre
Published: November 2023

Wine is a product of human creativity, culture, and nature, and therefore it is an intriguing subject for scientific research and admiration. Among its many kinds, white wine stands out oenologically because of its diverse flavours, aromatic attributes, and capacity to mature. In this experiment, we established 3 different bud load levels (25%, 50%, and 75%) on the well-known white wine grape variety ‘Fetească Albă’. The sugar content significantly increased in the 50% and 76% groups, whereas there were no significant changes regarding titratable acid content, must quantity, and cluster weight.
Correlation between chronic disease management program (prolanis) activities and health status of hypertension patients at Muara Satu community health center, Lhokseumawe city
Authors: Yuziani Yuziani - , Sofia Rizka
Published: November 2023

The Chronic Disease Management Program (Prolanis) is a program intended for people with chronic diseases such as hypertension which is quite effective but there are still many hypertensive patients who have not used the program. Hypertension is one of the causes of premature death due to the high rate of complications, the incidence of hypertension in the world continues to increase, especially in Indonesia. An increase in the incidence of hypertension will determine a person's health status. The purpose of this study was to identify the Chronic Disease Management Program (Prolanis), to identify the health status of Prolanis participants with hypertension, and to determine the relationship between Prolanis activities and the health status of hypertensive patients at the Muara Satu Subdistrict Health Center, Lhokseumawe City. The research method used a cross sectional research design, to analyze the relationship between Prolanis and the health status of hypertensive patients using the Chi Square test. The results showed the characteristics of the majority of Prolanis participants with hypertension were early elderly (46-55 years), female gender, not working, elementary school education, and marital status, as well as long suffering from hypertension with short duration occupying the highest position. The description of the degree of hypertension is more in the category of first-degree hypertension, most of the elderly who participate in Prolanis are in the good category (65.7%) and have the most health status in the good category (74.3%). The elderly who participate in Prolanis in the sufficient category will have sufficient health status (100%). Likewise, the elderly who participate in Prolanis in the good category will have a good health status (88.5). The conclusion of this study shows that there is a significant relationship between participating in Prolanis activities and the health status of the elderly.
Analysis of elderly anxiety levels in Baiturrahman area of Banda Aceh city during COVID-19 pandemic
Authors: Yuhardiati Yuhardiati , Ichwansyah Fahmi , Haris Amin , Abdullah Asnawi , Marthoenis Marthoenis
Published: November 2023

Introduction: According to the Covid-19 distribution map, it is evident that in Indonesia, the proportion of individuals aged 60 and above who tested positive for Covid-19 was 11.7%. Among this group, 13.7% received treatment or were isolated, while 10.3% successfully recovered from the illness. Unfortunately, the mortality rate among the elderly population stood at a significant 46.5%.Objectives: The objective of this study is to examine the extent of worry among the elderly population in the Baiturrahman district of Banda Aceh City in relation to the Covid-19 epidemic.Methods Materials: The research methodology employed in this study is analytical descriptive, utilizing a cross-sectional research design. The entire sample size consisted of 681 seniors, with a subset of 97 seniors selected using purposive selection technique. The application of logistic regression analysis for data analysis.Results: The study's findings indicated a significant association between various factors and old age anxiety during the Covid-19 pandemic in the Baiturrahman district of Banda Aceh in 2021. These factors include old age (P-value = 0.005), gender (P-value = 0.001), work (P-value = 0.0001), comorbidities (P-value = 0.001), home residence (P-value = 0.001), exposure of Covid-19 (P-value = 0.002), and quality of life (P-value = 0.010).Conclusion: The present study's findings indicate a significant association and potential danger between work-related factors, residential conditions, and anxiety levels among older individuals during the Covid-19 pandemic in the Baiturrahman area of Banda Aceh City in 2021. Bivariate analysis found that there is a relationship between elderly age, gender, work, comorbidities, living in the same house, Covid-19 history, and elderly quality of life to elderly anxiety in the Covid-19 pandemic situation in Baiturrahman District, Banda Aceh city in 2021. While the data from this study obtained no relationship between elderly education and vaccination against elderly anxiety in the Covid-19 pandemic situation in Baiturrahman District of Banda Aceh city in 2021.
Discharge against Medical Advice and its Relation to the Length of Stay and Re-admission Rates in Emergency Department at King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
Authors: Abowadaan Maha , Alnamlah Mohammad , Ghawnni Abeer
Published: November 2023

Objective:
This study aimed to identify the rate of discharge of hospitalized patients against medical advice (DAMA) and its risk factors, including length of stay as well as to assess patients' outcome after signing DAMA.
Methods:
This retrospective study included Saudi patients aged 14 years and above who were presented to the Emergency Department (ED) at King Faisal Specialist Hospital and Research Center in Riyadh, Saudi Arabia and left against medical advice from January 2021 to March 2022. Included patients were interviewed via phone calls to investigate the reasons of DAMA.
Results:
The study included 186 DAMA patients with 52.7% females and majority (21%) falling in the 30-39 years category. The most common complaint was shortness of breath (13.4%). The prevalence of DAMA was 0.89%. The length of stay in the ED was the common reason for DAMA (60.7%). The length of stay varied, and the highest percentage of patients (31.2%) stayed in the ED for 2-3 hours. Outpatient treatment was the most common outcome after DAMA (41.4%). There was a significant association between insurance type, the reason for leaving the hospital, and the length of stay in the ED (p=0.001 and p
NARRATIVE STRUCTURE ANALYSIS OF PALM TREE MYTH IN PEDAWA VILLAGE, BANJAR DISTRICT, BULELENG REGENCY
Authors: Nyoman Yulia Pratiwi  , Banda Maria Matildis , I Ketut Sudewa
Published: November 2023

Pedawa Village, located in Banjar District, Buleleng Regency, owns a myth about the palm tree growth in the village, which was told from one generation to another. The myth becomes guidelines for the villagers which is still applied at the present day. The purpose of the research is to break down the myth based on its narrative structure forms. To break down the myth the theory of narrative structure from Roland Barthes and Alan Dundes is used. Through the analysis process, it is revealed that this myth consisted of main function and catalytic function. Aside from that, the myth is also consisted of motifeme structure. The two breaking down processes proved that the myth fulfills the temporal and causality order.

Keyword: myth, Pedawa, palm tree, narrative, structure
ENHANCING STUDENTS' LISTENING SKILL: LEVERAGING EXTENSIVE LISTENING ACTIVITY IN AN EFL CLASSROOM
Authors: Desak Ayu Pradnya Gita Sasti  , I Dewa Gede Rat Dwiyana Putra  , Putu Santi Oktarina
Published: November 2023

This research aims to explore the best implementation of Extensive Listening in improving students' listening skill at grade eleven of SMK PGRI 3 Badung. The subject of this research is XI MM 2 class that consisted of 31 students. This Classroom Action Research (CAR) cyclic procedure consist of four stages, namely: planning, action, observation, and reflection. Observation and interview was done focusing on how the students respond to the implementation of the extensive listening method, while the test was administered in the end of class to check whether the applied method is effective. The result showed that the best implementation of Extensive Listening was found in the second cycle where drilling vocabulary was applied during pre-listening, practice and adaptation of speech rate were applied in whilst-listening, and exercises were emphasized in post-listening. This syntax was proven to successfully help the students to achieve the learning goal where 96,77% passed the minimum mastery criteria or KKM (75) with the class mean score of 89,67. Besides, students stated that they liked the teaching method and were more motivated in learning listening. Students confirmed that vocabulary and pronunciation drilling was considered effective and influential for their ability in doing the listening test. So, It could be concluded that: 1. drilling vocabulary should be implemented prior to the Extensive Listening main activities to ensure that the students have sufficient vocabulary, 2. teacher should justify the speech rate of the listening material during the Extensive Listening main activities to suit the students' ability.
OPTIMALISASI DESAIN DIDAKTIS MATERI PEMAHAMAN KONSEP PERBANDINGAN NILAI MELALUI IDENTIFIKASI DAN PENANGANAN LEARNING OBSTACLE
Authors: Haqq Arif Abdul , Amaliyah Nur , Wahid Sirojudin , Solahudin Iman
Published: November 2023

This research aims to develop an effective didactic design to address students' learning obstacles in the concept of value ratios. A qualitative research method was employed, specifically utilizing Didactical Design Research. Data were collected through tests, interviews, observations, and documentation from 8th-grade students at MTs PUI Kancana who had studied the subject matter. The didactic design was based on the analysis of learning obstacles and trajectories, metapedadidactics, and retrospectives. Following the implementation of the instructional design in 7th-grade class A at MTs PUI Kancana, which had not received prior instruction on value comparison, a decrease in students' learning obstacles was observed. Although not all learning obstacles were eliminated, the didactic design effectively reduced the barriers encountered by the students. This research holds significant implications for instructional development. By employing the didactic design for value ratios, it provides an alternative approach to enhance students' understanding and mastery of value comparison concepts. Consequently, this study offers an accurate and comprehensive overview of the didactic design approach to address learning obstacles in the context of value comparison. The findings highlight the importance of employing effective didactic designs to improve learning outcomes in the domain of value ratios.
Penggunaan telemarketing sebagai media dalam meningkatkan Jumlah nasabah asuransi jiwa dan kesehatan
Authors: Guntur Ajiselo  , Nursanti Siti , Lubis Flori Mardiani
Published: November 2023

Pada dunia bisnis asuransi kenyamanan pelanggan adalah hal yang sangat diutamakan. Kualitas pelayanan menjadi faktor terpenting untuk dapat bersaing di sektor industri jasa asuransi. Inovasi yang terus berkelanjutan tentunya dapat menjadi daya tarik bagi para nasabah atau calon nasabah. Tidak terkecuali dengan PT AXA Financial Indonesia. AXA Financial Indonesia memiliki motto customer first di mana pelanggan adalah hal yang sangat utama. Hal ini tidak terlepas dari strategi pemasaran yang dirancang untuk dapat bersaing dan tentunya mengajak lebih banyak orang untuk bergabung menggunakan produk asuransi yang ditawarkan. Penelitian ini menggunakan metode kualitatif deskriptif dengan teknik pengumpulan data melalui observasi dan wawancara mendalam dengan narasumber terkait. Teori yang digunakan adalah teori komunikasi pemasaran. Penelitian ini bertujuan untuk melihat strategi apa yang digunakan, tahapan, serta hasil akhir apakah dengan strategi pemasaran melalui telemarketing yang digunakan dapat meningkatkan jumlah nasabah serta pemasukan perusahaan. Tidak hanya itu, dalam penelitian ini juga melihat apa saja yang menjadi hambatan dalam proses pemasaran melalui telemarketing.
CORRELAÇÃO ENTRE MÁ HIGIENE BUCAL E COMPLICAÇÕES SISTÊMICAS EM PACIENTES INTERNADOS NA UNIDADE DE TERAPIA INENSIVA: UMA REVISÃO INTEGRATIVA DA LITERATURA
Authors: Mônica de Lima Elias Leite , Lívia Mirelle Barbosa , Sylvia Sampaio Peixoto , Maria Cecília Freire de Melo , Elizabeth Arruda Carneiro Ponzi , Jose Rodrigues Laureano Filho
Published: November 2023

Several studies have demonstrated the influence of oral diseases on the pathogenesis of several systemic diseases, especially in debtor patients, as they are more likely to the development of complications and disease dissemination. The aim of the study was to assess the correlation between poor oral hygiene and systemic complications in patients admitted to the ICU. An integrative literature review from 2010 to 2020 was carried out in Medline, Scientific Electronic Library Online, Scientific and Technical Literature of Latin America and the Caribbean, Virtual Health Library, using the search terms “dental biofilm”.
RESINA BULK FILL COMO ALTERNATIVA PARA PACIENTES GESTANTES: UM RELATO DE CASO
Authors: Maria Elisa Braga Almeida , Franciely Cruz Alves , Isabela Nobre Costa , Bárbara Gomes Tolentino , Edwaldo De Souza Barbosa Júnior , Danilo Cangussu Mendes
Published: November 2023

Aim: to describe, through a clinical case report an operational sequence of a single increment technique resin in a patient with special needs. Case report: a 30 year-old female patient, at 23 weeks of gestation, sought the dental care service of a dental care university reporting aesthetic dissatisfaction in the lower left second premolar. In the cold pulp vitality test, there was a positive response with rapid decline when removing the stimulus and the percussion and palpation test showed negative responses. The radiographic examination was not performed due to the clinical aspects described above, protecting the patient from exposure to X-rays. After comprehensive planning, it was decided to perform a dental restoration with a regular consistency Bulk Fill composite resin due to unique increment technique allows a shorter clinical time. Conclusions: Bulk Fill composites have become more popular in the dental clinic. In pregnant patients, this material can be considered the first choice due to its ease of insertion and time savings in direct restorations.
SOFTWARE EDUCATIVO SOBRE TEMA DE HIGIENE BUCAL: AVALIAÇÃO DE CRIANÇAS SOBRE A UTILIZAÇÃO DESTE RECURSO
Authors: Nary Danielle da Cruz Maciel , Luciane Campos Gislon , Elisabete Rabaldo Bottan
Published: November 2023

Objective: to know the evaluation of students about educational software with a theme related to oral hygiene. Methodology: this is a descriptive study, using primary data. 247 schoolchildren enrolled from the 1st to the 5th year of a basic education from private school participated in the research. The educational software, called Odontogame, was developed through the Unity3D program, based on the First Person Shooter model. Data collection took place through a questionnaire with open and closed questions. Data analysis was performed using descriptive statistical procedures. Results: most participants said they liked the game and would play more often. On a scale with a minimum score of 1 and a maximum of 5, the average score assigned to the game was 4.44. The average score for learning the content conveyed by the game was 4.53. Conclusion: the software can be used as a tool to facilitate the teaching-learning process to motivate good oral hygiene habits, being especially suitable for children between 6 and 8 years old.
Análise da mortalidade por neoplasias em duas décadas no município de Nova Iguaçu - RJ
Authors: Moura Paulo Henrique , Gomes Hélida Pimentel , Silva Maria Eduarda dos Santos , Sobreira Paula Guidone Pereira , Tavares Marília Salete , Moreno Adalgiza Mafra
Published: November 2023

Objetivo: Analisar a taxa de mortalidade por neoplasias na população do município de Nova Iguaçu de 2000 a 2019. Métodos: Estudo de coorte, analisando dados de óbitos por neoplasias especificadas no CID 10 subcapítulos (C00 a C97) do Sistema de Informação de Mortalidade, incluindo indivíduos com idade ≥ 20 anos, separados por sexo, ano, tipo de neoplasia, escolaridade, etnia, estado civil e faixa etária. Resultados: Foram registrados 14.875 óbitos por neoplasias, (sexo feminino 50,3%), média de 371,8 óbitos/ano. A taxa de mortalidade cresceu 68% de 2002 (77,8/100.000 hab.) a 2018 (113,5/100.000 hab.) com mortalidade proporcional variando entre 9% a 16%. O sistema digestivo acumulou mais óbitos, com faixa etária predominante entre 60-79 anos. Os subcapítulos C00-C14, C15-C26, C30-C39, C40-C41, C43-C44, C50, C51-C58, C60-63, C64-C68, C81-C96, demonstraram diferença dos óbitos entre os sexos (p≤0,05). Conclusão: A taxa de mortalidade por neoplasias quase dobrou em 20 anos, sendo maior no sexo feminino, com predomínio na faixa etária entre 60 a 79 anos em ambos os sexos. O maior número de óbitos por neoplasias foi referente ao sistema digestivo, seguido dos órgãos pulmonares e intratorácicos, 1/3 dos óbitos no sexo feminino foram referentes ao sistema mamário e órgão reprodutor.
Non-Pigmenting Fixed Drug Eruption Due to Fluconazole Without Cross-Reactivity to Itraconazole
Authors: Kovacs Timea , Davidson Christopher , Gibson Kacey , Richardson Jennifer
Published: November 2023

Fixed drug eruption is an uncommon cutaneous skin reaction that is most frequently attributed to antibiotics, non-steroidal anti-inflammatories, and paracetamol. Localized hyperpigmentation often results after the resolution of acute inflammation. Rarely, do fixed drug eruptions resolve without hyperpigmentation. Non-pigmenting fixed drug eruption (NPFDE) is an uncommon subtype that is characterized by well-demarcated, tender erythematous plaques that resolve without post-inflammatory hyperpigmentation. NPFDE has most frequently been associated with pseudoephedrine and piroxicam, but we report a case of a 48-year-old female with repeated occurrences of fluconazole-induced non-pigmenting fixed drug eruption. Clinical diagnosis of non-pigmenting fixed drug eruption was made based on the correlation of the lesion appearing within 2 hours after fluconazole ingestion, and previous history of similar reactions after fluconazole intake with resolution without residual pigmentation.
Deucravacitinib in Plaque Psoriasis: 3-Year Safety and Efficacy Results From the Phase 3 POETYK PSO-1 and PSO-2 Trials
Authors: Armstrong April W. , Lebwohl Mark , Warren Richard B. , Sofen Howard , Imafuku Shinichi , Ohtsuki Mamitaro , Spelman Lynda , Passeron Thierry , Papp Kim A. , Kisa Renata M. , Berger Victoria , Vritzali Eleni , Hoyt Kim , Colombo Matthew J. , Banerjee Subhashis , Strober Bruce , Thaçi Diamant , Blauvelt Andrew
Published: November 2023

Introduction: Deucravacitinib, an oral, selective, allosteric tyrosine kinase 2 inhibitor, is approved in the US, EU, and other countries for the treatment of adults with moderate-to-severe plaque psoriasis who are candidates for systemic therapy. Deucravacitinib was superior to placebo and apremilast in the POETYK PSO-1 (NCT03624127) and PSO-2 (NCT03611751) parent trials in moderate to severe plaque psoriasis. The POETYK long-term extension (LTE; NCT04036435) trial enrolled patients who completed PSO-1/PSO-2. We report safety and efficacy of deucravacitinib for up to 3 years (Week 148; through cutoff 6/15/2022).

Methods: PSO-1/PSO-2 randomized patients 1:2:1 to oral placebo, deucravacitinib 6 mg once daily (QD), or apremilast twice daily. At Week 52, patients enrolled in the LTE received open-label deucravacitinib 6 mg QD. Safety was evaluated in patients who received ≥1 dose of deucravacitinib using exposure-adjusted incidence rate per 100 person-years (EAIR/PY). Efficacy outcomes (≥75%/≥90% reduction from baseline in Psoriasis Area and Severity Index [PASI 75/90]; static Physician Global Assessment score of 0 [clear] or 1 [almost clear] with a ≥2-point improvement from baseline [sPGA 0/1]) were analyzed using modified nonresponder imputation (mNRI) in patients who received continuous deucravacitinib treatment from Day 1 of the parent trial and were treated in the LTE.

Results: Of 1519 patients who received ≥1 dose of deucravacitinib (3294.3 PY cumulative exposure), 513 patients received continuous deucravacitinib treatment from Day 1 in PSO-1/PSO-2 and were treated in the LTE. EAIRs/100 PY were comparable, or decreased, between the 2-year and 3-year cumulative periods, respectively, for AEs (154.4, 144.8), serious AEs (6.1, 5.5), discontinuations due to AEs (2.8, 2.4), herpes zoster (0.7, 0.6), malignancies (0.9, 0.9), major adverse cardiovascular events (0.4, 0.3), venous thromboembolism (0.1, 0.1), and deaths (0.4, 0.3). Response rates were maintained at Week 148 by mNRI (PASI 75, 73.2%; PASI 90, 48.1%; sPGA 0/1, 54.1%).

Conclusion: Deucravacitinib maintained a consistent safety profile and durable efficacy for up to 3 years.
Deucravacitinib, an Oral, Selective, Allosteric Tyrosine Kinase 2 Inhibitor, in Moderate to Severe Plaque Psoriasis: Evaluation of Creatine Phosphokinase Elevations in the Phase 3 POETYK PSO-1 and PSO-2 Trials
Authors: Lebwohl Mark , Strober Bruce , Scharnitz Thomas , Linaberry Misti , Hoyt Kim , Banerjee Subhashis , Kisa Renata M. , Martin George
Published: November 2023

Introduction: Deucravacitinib, an oral, selective, allosteric tyrosine kinase 2 inhibitor, is approved in the US, EU, and other countries for the treatment of adults with moderate-to-severe plaque psoriasis who are candidates for systemic therapy. In the phase 3 POETYK PSO-1 (NCT03624127) and POETYK PSO-2 (NCT03611751) trials, deucravacitinib was significantly more efficacious than placebo or apremilast and was well tolerated. This pooled safety analysis of POETYK PSO-1 and PSO-2 assessed changes from baseline in creatine phosphokinase (CPK) levels and CPK elevations and rhabdomyolysis adverse events (AEs) in patients receiving placebo, deucravacitinib, or apremilast.

Methods: Patients with moderate to severe plaque psoriasis were randomized 1:2:1 to oral placebo, deucravacitinib 6 mg once daily, or apremilast 30 mg twice daily. Shifts from baseline in severity grade (Common Terminology Criteria for Adverse Events [CTCAE] version 5) of CPK levels were analyzed. Elevated CPK and rhabdomyolysis adverse events (AEs) were reported.

Results: The pooled population included 1683 patients (placebo, n=419; deucravacitinib, n=842; apremilast, n=422). At baseline, the proportions of patients with grade ≥1 CPK levels were comparable (placebo, 6.3%; deucravacitinib, 5.9%; apremilast, 7.4%). During Weeks 0-16, worsening of CPK levels by >1 CTCAE grade from baseline occurred at similar rates in patients receiving placebo (2.2%), deucravacitinib (2.5%), and apremilast (1.4%). Most deucravacitinib-treated patients maintained their baseline CPK CTCAE grade or shifted to a lower grade through Week 52. Elevated CPK AEs were reported in 1.2% (placebo), 2.7% (deucravacitinib), and 0.7% (apremilast) of patients through Week 16. Exposure-adjusted incidence rates (EAIRs) of elevated CPK AEs through Week 52 were comparable across treatments (placebo, 4.5/100 person-years [PY]; deucravacitinib, 4.7/100 PY; apremilast, 3.6/100 PY). Two deucravacitinib-treated patients (0.2/100 PY) and 1 apremilast-treated patient (0.4/100 PY) discontinued due to AEs of asymptomatic elevated CPK. Two deucravacitinib-treated patients had rhabdomyolysis with potential inciting events, one of which was associated with CPK elevation.

Conclusion: Most deucravacitinib-treated patients maintained their baseline CPK grade or shifted to a lower grade through Weeks 16 and 52. The EAIR of CPK elevation AEs were comparable across treatment groups over 52 weeks.
A Systematic Literature Review and Network Meta-Analysis of Comparative Efficacy of Topical Fixed-Dose Combination Treatments for Moderate to Severe Acne Vulgaris
Authors: Harper Julie C , Baldwin Hilary E , Choudhury Saswata Paul , Ghosh Bikramaditya , Rai Deepti , Aman Md Sohail , Roy Choudhury Abhra , Dey Debalina , Dutta Sekhar K , Bhattacharyya Subrata , Lin Tina , Joseph George , Dashputre Ankur A , Tan Jerry
Published: November 2023

INTRODUCTION: Several topical and oral monotherapies/combination treatments are available for treating patients with moderate to severe acne vulgaris and a few are currently under review with the United States (US) Food and Drug Administration (FDA). Among these treatments, topical fixed-dose combinations (FDCs) are widely used in the US. No study has assessed the comparative efficacy of topical FDCs based on the treatment success endpoint of the proportion of patients achieving ≥2 grade reduction AND "Clear" or "Almost clear” status by week 12 on an Investigator's Global Assessment (IGA) or equivalent scales. The objective of this study was to conduct a systematic literature review (SLR) and network meta-analysis (NMA) to compare the efficacy of topical FDCs for the treatment of moderate to severe acne.

STUDY DESCRIPTION: An SLR was conducted for identifying randomized controlled trials (RCTs), that included at least one topical FDC (currently approved/under review with FDA) arm, in academic (MEDLINE, Embase, Cochrane CENTRAL, PEDE, and NHS EED) and non-academic databases (HTA databases, conference abstracts databases, and trial registries). The search was conducted in May 2022, based on a pre-specified inclusion/exclusion criterion. RCTs included in the analysis evaluated acne severity using IGA or equivalent (Evaluator's Global Severity Score, Investigator’s Static Global Assessment) scales. A Bayesian network meta-regression was conducted, using the proportion of patients with moderate acne, inflammatory and non-inflammatory lesion counts at baseline as covariates to account for acne severity.

RESULTS: Twelve Phase II/III/IV RCTs were identified from 5,159 citations comprising 8,349 patients across 8 treatment groups. The odds ratio for treatment success with topical FDC of clindamycin phosphate 1.2%, adapalene 0.15%, and benzoyl peroxide 3.1% (first triple agent FDC) gel was estimated to be 7.61 (95% Credible Interval: 4.44 –13.20) in comparison to Vehicle gel. Comparative effectiveness ranking demonstrated that the topical triple agent FDC gel was the most effective treatment with surface under cumulative ranking of 100%.

CONCLUSION: Based on this SLR/NMA, the topical triple agent FDC of clindamycin phosphate 1.2%, adapalene 0.15%, and benzoyl peroxide 3.1% gel, which is currently under FDA review (PDUFA date 10/20/2023), was clinically superior to all other topical FDC treatments for moderate to severe acne vulgaris.
Résumés des communications libres au Congrès de l'EuroPD de Bruges le 27/11/23
Authors: EuroPD 2023 Congrès
Published: November 2023

Ce numéro spécial du Bulletin de la Dialyse à Domicile (BDD) regroupe l’ensemble des résumés qui ont été soumis à l’EuroPD. Ces résumés sont disponibles en anglais et Français.
La version anglaise de ces résumés est la copie exacte des textes soumis par les auteurs au comité d’organisation du congrès de l’EuroPD. La version française a été en partie automatisée puis relue par un néphrologue, mais nous encourageons les lecteurs francophones à se référer à la version anglaise si une traduction leur semble inadaptée.
Ces résumés témoignent souvent de travaux particulièrement intéressants pour les cliniciens et infirmières et méritent de donner naissance à un article complet. Nous encourageons les auteurs de ces résumés à rédiger un article complet et à le soumettre au BDD à l’adresse : https://www.bdd.rdplf.org. Ils seront soumis en double aveugle à des pairs indépendants et, ceux acceptés, seront rapidement publiés dans les deux langues pour la plus large diffusion possible. Tous les articles ont un DOI Crossref qui permet une indexation efficace.
Le BDD soutient le plan d’action pour l’accès ouvert diamant dont il suit le modèle (Diamond OA scholarly Communication Ecosystem ) ; il est donc gratuit pour les auteurs comme pour les lecteurs, accessible à tous les professionnels de santé et aux patients.
Considérations éthiques : tous les auteurs ont été préalablement informés, avant la soumission de leurs résumés, que ceux-ci seraient publiés en libre accès dans le BDD et traduits en français. Les auteurs conservent le copyright de leurs articles.Déclaration d’intérêt : La publication de ces résumés est réalisée gratuitement par le Registre de Dialyse Péritonéale et hémodalyse à domicile de langue française, aucun payement ni subvention n’ont été reçus de l’EuroPD ou de tierce partie pour ce travail.Copyright: les auteurs conservent le copyright.
OFFENSES IN DECENTRALIZED SYSTEMS
Authors: Rafalskyi Maksym
Published: November 2023

Introduction. The article is devoted to the study of the problem of offenses in decentralized systems, in particular in blockchain networks. The author analyzes the main types of offenses that can occur in these systems, such as fraud, various attacks, and others. Since decentralized networks have no centralized control, they become more vulnerable to various types of attacks and abuses. Understanding the nature of decentralized networks can help to solve the problem of crimes in these systems more effectively, and understanding the principles of these networks can help to develop effective and transparent methods of solving such crimes.

Summary of the main results of the study. Taking into account the results of the research, an explanation is provided as to how decentralized networks such as blockchain are organized, what are the offenses in such networks, what are attacks in decentralized systems. A detailed list of the main types of attacks, other types of offenses and abuses in decentralized systems is also provided, a description and explanation is provided for each type, and specific examples are also provided for some of them.

Conclusions. For the first time, a list of the main offenses in decentralized networks such as blockchain has been unified and provided in the context of criminal law.
THE LAW OF UKRAINE "ON COPYRIGHT AND RELATED RIGHTS": ANALYSIS OF THE AMENDED PROVISIONS
Authors: Voloshchenko Olga
Published: November 2023

ANNOTATION. Introduction The European integration vector of Ukraine's legislative activity creates a powerful platform for improving domestic legislation. Ukraine, as a party to the Association Agreement between Ukraine and the European Union, undertook to harmonize a large number of domestic legal acts with the legislation of the European Union. The implementation of the set tasks in the outlined areas is achieved by adopting a number of laws that update the existing ones or add novelty to the provisions of the current legislation on intellectual property rights. The most recent "step" towards the approximation of domestic norms to the standards of the European Union was the adoption of a new edition of the Law of Ukraine "On Copyright and Related Rights".Studying the provisions of the latter in general gives a positive impression, taking into account the completeness of the wording of the procedures for acquiring exclusive property rights to individual copyright objects and their compliance with the Directives of the European Union. However, clarification of some provisions of the legislation, in terms of inaccuracies of the categorical apparatus, etc., requires a detailed doctrinal study.

Summary of the main results: The article provides the author's vision of the concept of the category "originality of the coposition", which is interpreted through the prism of the author's personal creative work and the presence of the undisputed presumption of legality of the work, which is proven in judicial or extrajudicial dispute resolution procedures. The statement regarding the emergence and existence of a new object of copyright - an NFT work - is proved. The conditions for providing legal protection of an NFT- work are defined, among which a specific one stands out - the need to destroy (destruction) a physical object of art in cases of tokenization of objects of fine art. The author expresses an opinion regarding the nearest prospect of securing such an object of copyright at the legislative level, which is determined by the requirements of practice. An opinion is expressed regarding the possibility of the existence of an NFT work, both as an original and as a derivative composition.

Conclusion. The conducted doctrinal study of the main provisions of the Copyright Law "On Copyright and Related Rights" made it possible to review the revised provisions from the "angle" of criticism and identify existing gaps with a list of recommendations for overcoming and eliminating the latter. However, the researched list of outlined issues is not exhaustive and contributes to further development of research in the specified field.
THE ROLE AND PLACE OF INFORMATION SECURITY IN THE OVERALL SYSTEM OF THE STATE'S NATIONAL SECURITY
Authors: Horulko Vladyslav
Published: November 2023

Introduction. The state's information policy is an important component of the state's foreign and domestic policy and includes all spheres of society. The rapid development of the information sphere causes the appearance of fundamentally new threats to the interests of the individual, society, the state and its national security. The fact that the information component is a stable object of manipulation in the conditions of hybrid war adds to the acuteness of the problem. Since the difficult political situation in which Ukraine has been in recent years, the continuous deterioration of the state's reputation on the international arena is caused by a number of factors, among which the inadequate state of the information security system is a significant factor. In Ukraine, there is an objective need for state-legal regulation of scientific, technical and information activities, which would correspond to the realities of the modern world and the level of development of information technologies, the norms of international law, but at the same time effectively protect Ukraine's own national interests.

Short list of main results. Summary of main results. The article examines the issue of information security as a component of the state's national security. The information security of the state is defined by the degree of its protection and the stability of the main spheres of life in relation to dangerous, destabilizing and destructive informational influences affecting the interests of the state both at the level of implementation and extraction of information. Internal and external information threats to Ukraine's national security and ways to ensure the country's information security are identified. In today's conditions, the informational component of the state's national security plays an extremely important role due to the risks and threats present in it, which include cyberterrorism, cybercrime, aggressive propaganda, the spread of anti-constitutional and anti-state slogans, limiting public access to public information, etc.

Attention is focused on the fact that the state information policy should reflect the urgent problems that have arisen in the information field. Effective implementation of strategic priorities, fundamental principles and tasks of the state policy of information security requires improvement of legal and organizational mechanisms of information security management.

Conclusions. The article proposes to consider information security as a necessary component of the state's national security, as well as a global problem of information protection, information space, information state sovereignty and information support for state decision-making.
DEFINITION OF THE EFFECT OF MARTIAL LAW ON POLICE POWERS
Authors: Pevko Stanislav
Published: November 2023

The introduction of the appropriate type of legal regime affects the legal status of both citizens and officials. The article investigated the issue of the factor of legal influence on police activities due to the introduction of a special legal regime of martial law through the prism of the scope of powers. Among the research methods of this topic, such as: analysis and deduction were used. That made it possible to make a comprehensive and comprehensive review of the scientific issue and made it possible to determine the essential elements that affect the dynamics of police powers in the conditions of the legal regime of martial law. Namely, it was determined what affects the change of static police powers when the legal regime of martial law is put into effect. At the same time, it is determined that the scope of police powers is not variable, but only the scope of the grounds for their application changes, which affects their possibility of application.

At the beginning of the article, an analysis of the essence of the National Police of Ukraine from the point of view of the doctrinal vision was presented. In the course of consideration of this issue, a review of the scientific works of scientists regarding the concept and historical origin of the police in the state was carried out. These results made it possible to determine the main role of the police and the purpose of its activity in society, which made it possible to further consider the main legal component of the relevant body and its employees, namely the powers. When considering the content of the powers of police officers, the comprehensive views of scientists on this issue were applied, which made it possible to define this concept. The powers of the police represent a measure of possible behavior, a set of rights and obligations specifically defined in the law, the implementation of which is carried out on behalf of the state in the person of the relevant authority. Speaking about the powers of the police, it was emphasized that their scope does not change even with the introduction of the relevant legal regime, but their expansion still takes place. Therefore, the question of the influence of the legal regime of martial law on the powers of the police was not concluded. In this connection, a theoretical and doctrinal review of the legal regime was carried out. From the normative side, the legal regime of martial law and its influence on the powers of the police were investigated. Based on the results of the analysis, the indirect effect of the legal regime of martial law on the powers of the police was established.

It was determined that upon the introduction of the appropriate legal regime on the territory of Ukraine, representatives of the National Police of Ukraine are given additional grounds for the use of authority in the form of measures of police influence. That thereby has a direct impact on the volume of cases for the application of police powers.