bluuebunny/crossref_metadata_2025 huggingface dataset:
Spatial memory impairment by hippocampal oxidative stress in male Long-Evans rats-Can it be prevented and/or alleviated by climbing exercise?
Authors: Ali Taskina , Amin Rokhsana Binte , Basak Puspita , Akter Fhamida , Islam Md Saiful , Islam Kazi Rafiqul
Published: February 2025

Background: Drug treatment for Spatial memory impairment has a wide range of adverse effects. Objective: To assess the effects of climbing exercise (CE)on spatial memory performance and hippocampal oxidative stress in colchicine induced memory impaired rats. Methods: Thirty male Long-Evans rats (8±2weeks; 225±75 gm)were grouped (6 rats/group)into normal control, sham control, colchicine control, pre colchicine CE and post colchicine CE. In CE, each rat performed 08 to 12 climbs/hour in a climbing tool for consecutive 28 days. Then, reference memory (RM) [Mean escape latency (EL) in acquisition phase, average EL of 5th and 6thacquisition days; number of target crossing (TC) and time spent in target (TT) in probe trial] and working memory (WM) [Mean EL and savings in training and test phase] were assessed by Morris water maze (MWM) test. Then, after sacrifice, hippocampal malondialdehyde (MDA) and glutathione peroxidase (GPx) were estimated. Data were expressed as mean±SEM and analyzed by one way ANOVA followed by Bonferroni’s post hoc test where p£0.05 was considered as statistically significant. Results: This study indicate that intrahippocampal colchicine administration significantly impaired spatial memory, and elevated MDA, decreased GPx level in hippocampus of colchicine control rats. In contrast, both pre and post treatment of CE significantly improved spatial memory retention and attenuated the oxidative damage almost to normal. Conclusion:CE is equally effective in prevention as well as alleviation of colchicine induced spatial memory impairment along with hippocampal oxidative stress in male Long-Evans rats.
J Bangladesh Soc Physiol 2024;19(1): 9-22
Competency Based Medical Education: Integrating two subjects- Physiology of Infancy
Authors: Mahajan Aarti Sood , Mahajan Akanksha
Published: February 2025

Infancy reflects a multisystem physiological transition from a dependent foetus to a newborn to a one-year-old child. This is a one-of-a-kind review of literature that is helpful for both medical graduates in concordance with the curriculum outlined by the National Medical Commission’s Competency Based Medical Education in India and for physicians to keep updated about infantile physiology. An in-depth review of literature shows a gradual transition in the physiology of different organ systems with unidirectional anatomical maturation. The respiratory system is characterised by increasing number of alveoli, diaphragm dominance, compliant chest wall, narrow compressible airway and periodic pattern of breathing. The cardiovascular physiology shifts to a left dominant system upon birth. Fetal hemoglobin gradually diminishes allowing greater unloading of oxygen at tissue level. The glomerular filtration, tubular concentration, gastric and hepatic enzyme secretion improves over the next 12-24 months. Infantile skin performs critical thermoregulation and there is evolution of adaptive immunity. There is substantial growth and acquisition of new developmental milestones with progressive neuronal myelination. The hypothalamic pituitary axis is established in infancy, responsible for the interplay of hormones. The review is a novel attempt to highlight marked functional and anatomical changes seen in all organ systems during first year.
J Bangladesh Soc Physiol 2024;19(1): 35-45
Flipping the Script: An Action Research Study on the Impact of the Flipped Classroom Technique on Student Engagement and Critical Thinking in Trinidad
Authors: Pragg Karima
Published: February 2025

Purpose: The contemporary learning environment is shifting towards innovative, learner-centered pedagogical approaches, such as the flipped classroom, that foster critical and engaged thinkers. This model replaces traditional lectures with pre-recorded online content students peruse before the class to facilitate interactive discussions and collaborative activities during face-to-face sessions. Methodology: This study investigated the impact of the flipped classroom on critical thinking and student engagement among six female sociology students at a Trinidadian tertiary institute over one semester. Data was gathered using an action research design utilizing mixed methods collected through classroom observations, student assessments, and student feedback. Findings: Post-intervention results demonstrated increased student engagement but no significant improvement in task completion rates. The study also noted a moderate increase in critical thinking skills reflected in students’ written assessments but stronger demonstrations during interactive class discussions and group activities in the flipped setting. Implications: While the small sample size and subjective nature of this action research limit the generalizability of the findings, the study offers valuable insights into the unique learning context of the participants and highlights the potential benefits of using the flipped classroom model in Trinidadian classrooms.
Radical Innovation in Leveraging AI Through Founder Mode: Scaling Social Impact in Solo-Founder AI-Driven Nonprofits Mode (SFADNM)
Authors: Zhu Yujia
Published: February 2025

The Solo Founder AI-Driven Nonprofit Mode (SFADNM) is a pioneering operational model that leverages artificial intelligence to address traditional challenges within the nonprofit sector, such as resource limitations, dependency on external funding, and scalability barriers. By adopting SFADNM, a single founder can lead a nonprofit without relying on extensive staff, financial support, or physical infrastructure, creating a lean, mission-centered organization. This model enables automation in essential functions, including user engagement, administrative tasks, and resource allocation, allowing founders to focus on strategic mission-aligned goals. Unlike conventional nonprofits, SFADNM facilitates sustainability by eliminating funding dependencies, thus creating an efficient, AI-powered structure that enhances reach and adaptability. A case study of FASSLING, an AI product line of the Canadian nonprofit For A Safer Space (FASS), was used to explore the efficacy of SFADNM to deliver personalized support services globally, offering a novel pathway for social entrepreneurs to maximize societal impact independently. This paper provides insights into how AI integration can redefine nonprofit operations by fostering mission-driven innovation without traditional financial dependencies, showcasing a sustainable alternative for mission-focused organizations.
Distribution Channel Dynamics: Sharing or not Sharing Information between Members?
Authors: Fouché Adèle , Fulconis François , Paché Gilles
Published: February 2025

Every distribution channel involves the efficient organization of product exchanges between manufacturers, large retailers, and wholesalers, typically supported by logistics service providers. Managing the physical flow of goods from factories to stores, pick-up points, or consumers’ homes necessitates the parallel exchange of information related to order tracking, stock levels, and order preparation, among other things. However, for strategic reasons, it is not uncommon for members of the distribution channel to be reluctant to share certain information deemed “sensitive” with their business partners. The question of whether to share information among distribution channel members has garnered significant interest from management researchers. Debates center around the appropriate level of informational transparency needed for a distribution channel to achieve optimal performance. This paper highlights the existence of two opposing views: one that focuses on the benefits of information sharing and another that emphasizes the associated risks. Building on this observation, whose major limitation is the binary nature of the information transparency/opacity dichotomy, the authors propose a “waves model.” The model identifies a succession of phases of information sharing and retention, which are influenced by the presence of critical incidents during a business relationship.
Project Management Practices in Defence Projects
Authors: Ikonen Ilkka , Pitkäkoski Henri
Published: February 2025

This article aims to contribute to both project management theory and practice by identifying the project management methods, tools, and techniques used in defense projects. Project management practices are identified in the literature, and empirical data is collected through a web-based survey of 53 project managers who represented the project officers and project managers of the Finnish Armed Forces. The results show that the top ten most used methods, tools, and techniques are well-known and widely utilized. These include project meetings, project reviews, workshops, expert screening, negotiation, course of action comparison, brainstorming, project audits, and checklists.
ANALISIS PEMBELAJARAN BERBASIS TEACHING FACTORY PADA PENDIDIKAN VOKASI MARITIM TERHADAP CAPAIAN DARI PROFIL LULUSAN
Authors: Widiatmaja Arya , Sari Dian Kurnianing , Khamdilah Ali
Published: February 2025

Tujuan dari penelitian ini adalah Mengetahui sejauh mana  pembelajaran berbasis teaching factory dapat diterapkan pada pendidikan vokasi maritim  sebagai upaya meningkatkan kompetensi lulusan bagi peserta didik sesuai harapan stakeholder. Dengan latar belakang kebutuhan capaian pembelajaran lulusan sesuai dengan keinginan industry sebagai pengguna lulusan.. Dengan pokok masalahnya yaitu penerapan pembelajaran berbasis metode teaching factory terhadap keefektifan capaian pembelajaran sesuai kebutuhan industry. Penelitian ini merupakan penelitian kualitatif diskripstif yaitu dengan melakukan observasi pada Lembaga Pendidikan dalam menggunakan  metode  teaching factory sebagai metode pembelajaran yang meliputi: sarana dan prasarana, system pembelajaran, tenaga pendidik sebagai subyek pengguna teaching factory dan peserta didik sebagai obyek dari penerapan metode teaching factory. Mania,S (2008) menyatakan bahwa observasi merupakan suatu metode dalam menghimpun suatu data yang didapatkan ketika melakukan proses pengamatan terhadap fenoma yang telah diamati dan dilakukan secara sistematis. Penelitian ini difokuskan pada penggunaan metode teaching factory apakah sudah sesuai jika diterapkan pada Lembaga Pendidikan kemaritiman yang meliputi: aspek sikap , aspek pengetahuan, aspek ketrampilan umum dan aspek ketrampilan khusus yang digunakan pada indikator kompetensi. SWOT analisys digunakan untuk  mengukur kelebihan ataupun kekurangan dari teaching factory. SWOT Analysis merupakan metode yang digunakan untuk menganalisa kekuatan, kelemahan, peluang dan ancaman dalam suatu spekulasi bisnis  ( Fajar Nur’aini, 2019). Kesimpulan yang didapat dari penelitian Analisis Pembelajaran Berbasis Teaching Factory  Pada Pendidikan Vokasi Maritim Terhadap Capaian Dari Profil Lulusan  bahwa Penerapan metode teaching factory bisa dilaksanakan tetapi tidak hanya berorientasi pada satu mata Pelajaran tetapi bisa didesain sesuai dengan capaian pembelajaran lululusan yang mengarah pada profil lulusan suatu Lembaga Pendidikan. Dari hal tersebut perlu adanya konsep tersendiri pada rencana pembelajarannya. Sasaran hasil akhir yang dituju mengalami hambatan tersendiri  menyangkut kondisi dan situasi lingkungan Lembaga pendidikan berbeda dengan lingkungan industri terutama pada budaya dan komunikasi yang dibangun meskipun sarana dan prasarana sudah sangat mendukung untuk pelaksanaan metode teaching factory.
Study of the Solution of one Nonlinear Integro-differential Equation of Fourth Order.
Authors: Aizharkyn Zh. , Zholdoshova Ch.
Published: February 2025

There is considered a nonlinear integro-differential equation in partial derivatives of the fourth order, the existence and uniqueness of a local solution are proved, and the conditions for the existence of a local solution are determined. The proof is carried out using the method of an additional argument. Recently, this method has been used to reduce nonlinear differential equations in partial derivatives of high order into integral equations and systems of integral equations. This method was developed by Kyrgyz scientists and used to solve nonlinear differential equations in partial derivatives of the first order. Currently, the method of the additional argument is being developed for various new classes of nonlinear partial differential equations of higher order and systems of nonlinear partial differential equations. The nonlinear partial differential equation of the fourth order discussed in the article is presented in operator form, with the method of the additional argument applied consecutively several times. As a result, an integral equation is derived, and the existence and uniqueness of the solution to this integral equation are determined using the contraction mapping principle. The unknown function in the integral equation contains an additional argument, and by equating this additional argument to time, a local solution to the original initial value problem can be obtained. The results presented in the article can be applied in the study of solutions to other nonlinear differential and integro-differential equations of higher order.
Prospects for Oil Bearing Capacity of the Pre-Jurassic Formations within the Khanty-Mansiysk-Frolovsk Search Area
Authors: Biryukova O. , Konovalenko M.
Published: February 2025

The low hydrocarbon potential of the pre-Jurassic rocks of Khanty-Mansiysk Autonomous Okrug - Yugra has, on the one hand, a geological justification, but on the other hand, the degree of this justification raises serious doubts due to the extremely low geological and geophysical study of this structural stage. However, geological discoveries of recent years, which include not only drilling of new deep wells, but mainly re-processing and re-interpretation of previously obtained seismic and drilling materials, allows to reconsider the degree of prospectivity of the pre-Jurassic deposits in the direction of increasing its oil potential. The article, based on the geological and geophysical works and complex seismic stratigraphic analysis of the Khanty-Mansiysk-Frolovskaya zone, substantiates the necessity to continue prospecting and exploration drilling at the most reliably identified oil and gas promising sites in the Lower Jurassic and pre-Jurassic rock complexes.
The Activity of Catalase and Superoxide Dismutase under the Influence of Fe and Zn Oxide Nanoparticles in Wheat Sprouts
Authors: Ismayilova G. , Azizov I.
Published: February 2025

This study examined the effects of ferric oxide and zinc oxide nanoparticles (NPs) at various concentrations on the activity of antioxidant system enzymes (superoxide dismutase and catalase) in the sprouts of durum and soft wheat varieties. The research objects included durum wheat varieties (Triticum durum Desf.) Gyrmyzy Bugda, Garagylchyg-2, Yagut, and Karabakh, as well as soft wheat varieties (Triticum aestivum L.) Mirbashir-128, Gobustan, Sheki-1, and Dagdash. To determine the optimal concentrations of nanoparticles influencing the activity of antioxidant enzymes in different wheat varieties, molar concentrations of zinc oxide NPs (0,1 mM, 0,01 mM, and 0,001 mM) and mass concentrations of ferric oxide NPs (15 mg/kg, 30 mg/kg, 50 mg/kg, and 100 mg/kg of soil) were applied. The highest catalase activity was observed at a zinc oxide NP concentration of 0,01 mM for both durum and soft wheat varieties. For ferric oxide NPs, the optimal concentration was found to be 30 mg/kg for durum wheat varieties and 15 mg/kg for soft wheat varieties. Thus, ferric oxide and zinc oxide nanoparticles show potential for use as pre-sowing seed treatments for various durum and soft wheat varieties. However, determining the optimal NP concentrations for the specific crops being studied is a critical requirement for their effective application.
Taxonomic Diversity of Euphrasia Species in Nakhchivan: a Botanical Overview
Authors: Talibov T. , Bayramova S.
Published: February 2025

The genus Euphrasia (family Orobanchaceae) encompasses a diverse group of plants, characterized by their parasitic nature and their wide distribution across temperate regions of the world. In this study, we aim to provide a detailed botanical overview of the taxonomic diversity of Euphrasiaspecies in the Nakhchivan Autonomous Republic, located in the South Caucasus. This region, with its diverse ecological habitats and varied climatic conditions, offers a unique setting for the study of plant diversity. The Euphrasiaspecies in Nakhchivan represent a significant portion of the genus' global diversity, contributing to both its ecological dynamics and cultural importance. This paper discusses the current knowledge of Euphrasiaspecies in the region, their taxonomic classification, ecological distribution, and conservation status.
Conclusions of Botanical Research. Discussion and Analysis of the Results Obtained
Authors: Ganbarov D.
Published: February 2025

This scientific research presents the studies conducted from 2021 to 2025 and the results obtained from those studies. The materials of the research obtained in different years can be used in the teaching of "Systematics of Higher Plants", "Systematics of Plants", "Medicinal Plants of Nakhchivan Autonomous Republic", and "Local Flora" courses in the Master's and Doctoral programs at the Biology and Biology Teaching specialties.
Ecological Spectrum of Gammarus lacustris (Sars, 1863) (Malacostraca, Amphipoda, Gammaridae) of the Araz Water Reservoir
Authors: Bayramov A. , Maharramov M. , Akhmedova K.
Published: February 2025

The relation of the dominant species of macrozoobenthos of Araz reservoir Gammarus lacustris to substrate, depth, water transparency, illumination, temperature, oxygen regime and organic pollution of aquatic environment was studied. It is established that the freshwater shrimp has high ecological plasticity to abiotic factors of the environment. It was confirmed that in aquatic conditions the abundance of sunlight causes a clear negative phototropism in individuals of the higher crayfish. The species proved to be resistant to the average degree of environmental pollution by organic substances (s = 0.5 oligo - 2.5 β - mesosaprob) in the Araz reservoir. It was found that there are favorable ecological conditions for the development of the crayfish population in the ecosystem. The average annual number of crayfish individuals in the reservoir was 23 individuals/m2, biomass — 0.120 g/m2. The quantitative composition of the population is subject to seasonal changes. The highest values of freshwater shrimp abundance and biomass were calculated in spring and autumn.
Autecology of Species Belonging to the Falco Family Spreading in the Nakhchivan Autonomous Republic
Authors: Novruzov H. , Huseynov H.
Published: February 2025

The article provides information on the autecology of species belonging to the Falco genus spreading in the Nakhchivan Autonomous Republic. From the conducted research, it was found that 7 species of the genus Falconidae of the Falco family are found. Also, from the research it is clear that 2 species of birds belonging to the Falco genus are wintering, 1 species is migratory, 3 species are nesting, and 1 species is sedentary.
Impact of Genetically Modified Organisms on Human Health
Authors: Mammadov H. , Gulamova A.
Published: February 2025

Investigates the impact of genetically modified organisms (GMOs) on human health. It is noted that the use of GMOs is increasing yearly worldwide. While gene technology, which has entered our lives through the creation of genetically modified organisms, shows benefits, it also presents certain challenges. These challenges include negative impacts on distribution and balance, toxic effects on plants, difficulties in fighting pathogens due to the development of antibiotic-resistant genes, gene transfers, and an increased risk of allergic reactions due to GMOs, all of which raise relevant questions about genetically modified organisms. It is highlighted that in recent years, biotechnology and the use of genetically modified organisms (GMOs) developed through biotechnological research methods are among the topics of most interest worldwide. Based on the information obtained from the research, the article explores the potential benefits, harms, and risks of genetically modified organisms, their effects on biodiversity, socioeconomic and legal dimensions, as well as consumer perspectives. In conclusion, it is stated that since the opinions of scientists around the world about the benefits and harms of GMO products are not unanimous, it would be more appropriate to consider the favorable natural conditions in our country for the cultivation of agricultural products and use ecologically clean food products.
Creation of a Composite System Based on Pyrolysis Resins and Pyrogenetic Water using the Cavitation Effect
Authors: Abdaliev U. , Ysmаnоv Е. , Urmatkyzy Zh. , Tashpolotov Y.
Published: February 2025

In this work, coal from the coal basins of the southern region of Kyrgyzstan (Uzgen Kara-Debe, Alay Zak-Kashkasuu, Kadamjai Bel-Alma, Sulyukta open-pit mine No.4) is taken as the main raw material, and on the basis of the products obtained from it, it is envisaged to create composite systems as a fuel. In the experiments, we placed 1000 g of pre-weighed coal in a reactor to determine the release of volatile substances, and then subjected it to slow pyrolysis to a given temperature in a stainless steel reactor, ensuring tightness. Pyrolysis was carried out for brown coal from 100 ° C to 550 ° C and for hard coal from 100 ° C to 1100 ° C, i.e. it was carried out until the release of liquid and gaseous products ceased. The calorific value of coals was determined by a colorimetric bomb. Based on the cavitation effect, a stable composite system was created, consisting of 10 micron coal powder + coal tar + pyrogenetic water + water + plasticizers. It was found that the cavitation effect is high for obtaining a homogeneous, stable, dispersed composite system. Voltage of 16 volts is enough for the combustion process to occur, and the efficiency during combustion can be increased by 4-6% due to fogging of the chrome coil heated to 4000C, and this will bring economic benefits. During combustion, the content of harmful substances (CO, H2S, NO, SO2, C2-C12) is released in an amount that does not exceed the norm.
Innovative Production Complex Based on Renewable Energy Sources
Authors: Turduev I. , Zhusubalieva A. , Turapov A. , Mambetuulu B.
Published: February 2025

This article provides an overview, analysis and solutions to the problems of efficient energy supply in Kyrgyzstan using renewable energy sources. The composition of the equipment used and the economic aspects of practical application are considered. It is shown that the use of alternative sources based on renewable energy sources is a promising solution for decentralized power supply in rural areas and remote facilities.
Pharmacoepidemiological Analysis of Drug use in Elderly Patients with Cardiovascular Diseases that Increase the Risk of Falls
Authors: Sharaeva A.
Published: February 2025

This article updates the problem of falls in elderly patients, the causes of which are multifaceted. Age is one of the main factors contributing to the increase in the number of falls, since fatal cases associated with falls most often occur among the elderly. Falls create a huge burden on the health care system, since injuries such as hip fractures require expensive treatment. Many risk factors increase the likelihood of falls in the elderly, and medications are among these factors. And in this study, a pharmacoepidemiological analysis of the use of drugs in elderly patients with cardiovascular diseases was carried out, the purpose of which was to identify drugs that increase the risk of falls using medication and falls risk classification guide. A retrospective analysis of prescription sheets of medical records of patients over 60 years old with cardiovascular pathology who received treatment in a hospital was carried out. According to our data, 82 patients were prescribed drugs with a high risk of falls in 56% of cases and a moderate risk of falls in 44% of cases. The high-risk group included: benzodiazepines, which were prescribed to 12 patients (5%), ACE inhibitors (ACEi) - 39 patients (14.5%), β-blockers - 55 patients (21%) and antianginal drugs - 38 patients (15%) and were in the red color according to the traffic light classification. As a result of the analysis, it was concluded that patients in the above categories are prescribed drugs, often in combination, that increase the risk of falls and lead to them. It is recommended to improve the knowledge of health care workers, develop clinical guidelines for the care of elderly patients, update existing clinical guidelines for the care of patients with cardiovascular diseases with the inclusion of the medication and falls risk classification guide in them to prevent falls in elderly patients.
Assessment of the State of Public Health in Kyrgyzstan
Authors: Amirakulova A.
Published: February 2025

This paper examines the assessment of the state of public health in Kyrgyzstan based on the analysis of demographic, socio-economic and health indicators. The purpose of the study is a comprehensive assessment of the state of public health in Kyrgyzstan, analysis of the demographic situation and migration processes in the context of their impact on the socio-economic development of the country. The study aims to identify key factors influencing public health, as well as to develop recommendations for improving health care and social policy. The study covers the period from 2020 to 2024 and includes data on population size, age structure, birth and death rates, life expectancy, infant and maternal mortality, as well as migration processes. Materials from official statistics, reports of international organizations, scientific publications and data from independent analytical centers were used. The research methodology includes statistical analysis, comparative approach, content analysis of scientific publications and modeling of demographic trends. The focus is on identifying key problems in the health sector, such as the uneven distribution of health services, staff shortages and access to care. The study results show that despite positive trends in improving population health, significant challenges remain in improving the quality of health care, accessibility and effectiveness of health services, as well as reducing mortality rates and improving life indicators.
Metabolically Associated Steatotic Liver Disease and the Possibilities of Using Antihypertensive and Hypolipidemic Medications
Authors: Karshina O. , Mohammad E. , Inarkiev R. , Fazilova S. , Khankishiev A. , Sabirov I.
Published: February 2025

Metabolically associated steatotic liver disease (MASLD) is one of the most common liver pathologies. Metabolically associated steatotic liver disease is closely linked to metabolic syndrome, including obesity, type 2 diabetes, dyslipidemia, and arterial hypertension, making it not only a gastroenterological issue but also a significant aspect of cardiometabolic diseases. An important task is finding effective treatments aimed at improving the condition of such patients. In recent years, antihypertensive and hypolipidemic drugs have gained attention as potential means for correcting the disorders associated with MASLD. This article analyzes the impact of these drugs on disease progression, considering their effects on lipid profiles, blood pressure, inflammation, and liver fibrosis. Various classes of antihypertensive agents, such as ACE inhibitors, angiotensin receptor blockers, and calcium channel blockers, as well as hypolipidemic drugs, including statins, fibrates, and omega-3 fatty acids, are discussed. Clinical data evaluation indicates that combined therapy with antihypertensive and hypolipidemic drugs may positively affect the reduction of steatosis, inflammation, and liver fibrosis, while also improving the cardiometabolic profile of patients. However, further studies are needed to develop optimal treatment regimens and more accurately determine the effectiveness and safety of these drugs in the context of metabolically associated steatotic liver disease.
Systemic Scleroderma, Clinical Variants of the Course
Authors: Murkamilov I. , Aitbaev K. , Yusupov F. , Raimzhanov Z. , Yusupova Z. , Yusupova T. , Khakimov Sh. , Solizhonov J. , Khabibullaev K.
Published: February 2025

Systemic scleroderma (SSc) is one of the most common autoimmune diseases among women, with a peak incidence between the ages of 44 and 55. Rheumatology distinguishes several clinical forms of SSc: diffuse, limited (localized), juvenile (onset before 16 years), and overlap (mixed) forms. SSc is a classic heterogeneous disease with a wide range of clinical manifestations and varied courses. The most frequent initial symptom is Raynaud’s syndrome, which can be either primary or secondary. The onset of SSc in older adults requires thorough laboratory investigations to rule out oncological causes. This article presents a clinical case of SSc with periods of exacerbations and remissions. The 58-year-old patient’s disease began with Raynaud’s syndrome and elevated inflammatory markers. A year later, targeted testing revealed serological markers of SSc, while inflammatory markers were not elevated despite the progression of Raynaud’s syndrome.
Problems of Socio-Medical Rehabilitation of Citizens Who Have Recovered from the New Coronavirus Infection
Authors: Zhorobekova M. , Baitova G. , Akbaeva D.
Published: February 2025

The article examines the main issues related to the socio-medical rehabilitation of citizens who have recovered from COVID-19. It highlights the challenges faced by healthcare systems in organizing comprehensive rehabilitation programs, to the needs of different age groups and vulnerable populations, as well as the importance of psychological support and physical recovery. The study also emphasizes the role of interdisciplinary cooperation and the development of personalized rehabilitation strategies to improve the quality of life for patients after recovery.
Methods of Medical Rehabilitation for Patients Recovering from COVID-19
Authors: Zhorobekova M. , Baitova G. , Akbaeva D.
Published: February 2025

The COVID-19 pandemic has left a significant number of patients suffering from long-term symptoms and complications requiring comprehensive rehabilitation strategies. This article reviews contemporary approaches to post-COVID rehabilitation, highlighting respiratory and cardiovascular recovery, psychological support, and physical rehabilitation methods. The study focuses on age-specific rehabilitation needs and evaluates the effectiveness of various methodologies based on clinical trials and empirical data.
Dynamics and Factors of Prevalence of Respiratory Diseases among Different Age Groups of the Population of the South of Kyrgyzstan
Authors: Alimova N. , Muratov A.
Published: February 2025

Respiratory diseases remain one of the leading causes of morbidity and mortality in the world, especially in the context of increasing urbanization and environmental pollution. This article analyzes the dynamics of the prevalence of respiratory diseases in the Kyrgyz Republic for the period 2019–2023, taking into account age and regional characteristics. Particular attention is paid to the impact of the COVID-19 pandemic, which has changed the availability of medical care and the structure of morbidity. The purpose of the study is to analyze the dynamics and factors of prevalence of respiratory diseases among various age groups of the population of the Kyrgyz Republic in 2019–2023 in order to develop recommendations for the prevention and improvement of the organization of medical care. The work uses modern methods of statistical analysis and digital tools to assess epidemiological trends. The study results demonstrate significant regional differences in the prevalence of diseases, as well as a high correlation between the dynamics in children and adults. Based on the data obtained, recommendations for the healthcare system are proposed, including strengthening preventive measures and the use of telemedicine technologies. The article highlights the importance of an integrated approach to monitoring and preventing respiratory diseases, as well as the role of digitalization of healthcare in improving the efficiency of data management.
Studying the Effect of Diet on a Woman's Menstrual Cycle
Authors: Tkhoruk M. , Dumenko V. , Yashchuk I. , Sarchuk E.
Published: February 2025

Regularity of the menstrual cycle is an indicator of a woman’s overall health. The article presents the results of a study of the effect of diet on a woman’s menstrual cycle. The issues of the relationship between different stages of the menstrual cycle and the body’s needs for nutrients as one of the factors in maintaining regularity of menstruation and reducing the manifestations of premenstrual syndrome in women are considered. The data obtained during the study can be used to increase women’s awareness of the importance of a balanced diet to maintain hormonal balance and improve quality of life. The results can be useful for both health professionals and women seeking to optimize their health through proper nutrition.
Frequency and Overlap of Geriatric Syndromes in Patients According to Age Groups during Inpatient Hospitalization
Authors: Musakeev A. , Murzaibragimova M. , Smailova D. , Nartaeva A.
Published: February 2025

Given that geriatric syndromes are significant causes of mortality, morbidity and increased health care costs, we determined the frequency of geriatric syndromes such as malnutrition, dementia, depression, falls, polypragmasia and urinary incontinence in 770 elderly patients who were hospitalized in the Clinical Hospital of the Presidential Administration of the Kyrgyz Republic and underwent a comprehensive geriatric evaluation. The frequency of polypragmasia was 54.5%, urinary incontinence 47.6%, malnutrition 9.6%, depression 35.1%, dementia 21.6%, and falls 33.6%. When all participants were divided into two groups (60-74, 75-89), all syndromes increased significantly with age except depression. While 20% of cases in the 60-74 age group had two syndromes verified, 48% of cases in the 75-89 age group had more than four syndromes simultaneously. The frequency and overlap of geriatric syndromes, except depression, increased with age.
Influence of a complex of grotechnical measures on the development of local and introduced varieties of winter wheat (Azerbaijan)
Authors: Kazimov N. , Seyidaliev N.
Published: February 2025

The results of the studies of winter grain development are considered. Depending on the effect of agrotechnical measures applied in the course of scientific research, as well as biological and morphological characteristics of varieties, the phase of full ripening of fruits will occur for the varieties "Gyrmyzygul", "Murov-2", "Aran", "Maurizio", "Balaton", "Gallio" and "Gaudio" at different doses of fertilizers and irrigation rates, as well as in dryland conditions by development phases. It was revealed that the vegetation period of the varieties "Gyrmyzygul" and "Balaton" ended 3-5 days earlier than that of other varieties.
The Influence of the Feeding Rate of the Silkworm on Its Selection and Breeding Indicators in the Ecological Conditions of Azerbaijan
Authors: Abdullaeva L.
Published: February 2025

The formation of all living organisms, including the silkworm, occurs under the influence of environmental and hereditary factors. The environmental factors that affect the growth, development, and fertility of the silkworm include the quality and quantity of feed, temperature, humidity, feeding area, etc. It should be noted that the development, growth, and fertility of the silkworm are most influenced by the feed factor. One of the most important tasks facing the science of sericulture is to obtain a large number of high-quality cocoons using mulberry leaves in a single amount. In our experiment, we used leaves of the Khanlar-tut mulberry variety. The following introduced species were selected from the breeds: Çin-21, Çin-29, Ukrayna-1, Ukrayna-2, which were grown in sheltered rooms. The experiment consisted of subgroup II and variants IV. During the experiment, the adaptation of these breeds to the conditions of our region, as well as the reaction to leaves (feed) of local mulberry varieties, the influence of the quantity and quality of feed were studied. These studies will provide important assessments and recommendations for the cultivation of silkworms using mulberry leaves to increase productivity, improve quality and, most importantly, reduce the cost of production.
On the Question about Some Biochemical Changes in the Blood during Enzootic Ataxia of Buffalo Cats.
Authors: Ibragimov A. , Maharramov M.
Published: February 2025

In order to study biochemical changes in the blood of animals with enzootic ataxia, total and residual nitrogen, total protein, protein fractions, the content of ammonia, urea and bilirubin, as well as the content of creatinine and alkali in the blood serum of 50 clinically healthy and 32 sick animals were comparatively determined. As a result of the examinations, it was found that total protein, the content of total nitrogen and the alkaline reserve of blood in the blood of sick buffaloes decreased compared to healthy animals; on the contrary, the content of residual nitrogen, urea, ammonia and creatinine increased. This shows that during an enzootic attack, a profound metabolic disorder, especially protein metabolism, occurs in the body of sick animals.
Analysis of Macroeconomic Indicators as a Method of Assessing the Impact of the External Environment on the Formation of a Construction Organization's Strategy
Authors: Soltogulova M.
Published: February 2025

For the successful development of an organization in any field, it is necessary to build a competent development strategy. The formation of a construction company's strategy is influenced by external and internal factors. The article analyzes macroeconomic indicators as one of the methods for assessing the impact of the external environment on the formation of a construction organization's strategy. The impact of such macroeconomic indicators as GDP, unemployment and the number of employed people in the construction industry, the inflation rate, and changes in the exchange rate is considered.
Foreign Practice of Forming a Digital Management System in the Banking Sector
Authors: Abdykadyrov K. , Toichubekuulu A.
Published: February 2025

Digitalization is becoming a key factor in the competitiveness of banks in the international arena, including in the CIS countries. This article analyzes foreign examples of the implementation of digital management systems, including successful models, approaches, technologies used and statistical data showing how digitalization improves the efficiency of banking operations. It is important to note that the transition to digital technologies is not just a trend, but also a necessity to maintain competitiveness in a rapidly changing market. Modern banks face numerous challenges, such as changing customer needs, increased competition from fintech companies and the need to comply with strict regulatory requirements. In the context of rapid technological progress, banks are forced to modernize their management systems. According to a report by Accenture, banks that actively implement digital solutions can increase their profits by 30% within five years. At the same time, according to McKinsey estimates, 70% of digital transformation projects do not achieve expected results due to insufficient attention to the culture and change processes in management. Digitalization helps improve customer service and optimize internal processes.
Theoretical Approaches to the Analysis of Work-Life Balance
Authors: Sadullaev Sh.
Published: February 2025

Analysis of life and work balance is becoming an important issue in the modern socio-economic environment. As a result of technological development and globalization, people face difficulties in maintaining balance between family and professional life. This article examines the main theoretical approaches to ensuring work-life balance, their methodology and effectiveness.
Constitutional and Legal Regulation of Economic Development in the Kyrgyz Republic According to the Constitution of 2021
Authors: Bakalbaev Z.
Published: February 2025

The article discusses the provisions of the Constitution of the Kyrgyz Republic of 2021, defining the socio-economic foundations of the constitutional system
General Characteristics of Offences in the Sphere of Customs Regulation
Authors: Kalymbetova D.
Published: February 2025

The proposed article reflects the general theoretical understanding and legal essence of responsibility for offenses in the customs sphere. Currently, one of the important strategic directions for improving the work of customs authorities of the Kyrgyz Republic is the prevention of offenses in the customs sphere and the prevention of this phenomenon. Violation of customs rules is known to have a significant impact on the economic and national security of the state as a type of offense in the customs sphere. The methodological basis of the scientific article is dialectical, system-structural, comparative-legal, logical, economic and other methods. The results of the study are aimed at increasing the efficiency of customs authorities in combating offenses in the customs sphere, as well as improving the legislation related to responsibility for offenses in the customs sphere of the Kyrgyz Republic.
Absolute Monarchy or Rule by One Sovereign
Authors: Bekmurzaeva G. , Osmonov S. , Kurbanova A.
Published: February 2025

The theorist and ideological inspirer of absolute monarchy is undoubtedly the thinker of political philosophy Thomas Hobbes. All philosophers developed their political theories in conditions of a crisis of power, chaos, change, war or upheaval that engulfs society. According to Hobbes's view, only a sovereign (a person endowed with legitimacy and possessing full power) can impose law and stability, that is, Hobbes puts us before a choice - stability and security in exchange for the concentration of power in one hand, transmitted by inheritance, otherwise - chaos, revolution, war. And even if there are abuses with the concentration of absolute power in one hand (dynasty), then society will still remain stable. According to Hobbes, compromise (or social contract) means an agreement between people to abide by certain laws or rules, so that these laws and rules are followed, and to ensure that the contract is carried out, there must be a force (or institution) that has full power. Only then will order and stability be ensured in society. But the supreme power in the state must be in the hands of one person, and not a group of people, that is, a king, tsar, sultan, khan. If society passed through its stages of development under absolute monarchy or authoritarian rule, then in our time people can no longer live like that. Authoritarianism and tyrants not only slow down the development of society but are also dangerous for the state, leading to revolutions, riots or civil wars. The examples of Libya and Syria show that authoritarianism sooner or later leads to chaos. Moreover, in authoritarian countries, the ruler endowed with unlimited power sometimes becomes an object of almost or not deification.
Readiness for Professional Activities of Future Physical Education Teachers
Authors: Usonuulu Zh.
Published: February 2025

The theoretical study of the professional training of physical education teachers considers this process as a dynamic one, in which educational goals are realized and the necessary competencies are formed. An important aspect is the creation of an integrated system of continuous learning that promotes personal development and training of personnel in various areas of educational activity, taking into account the needs of participants in the pedagogical process. The training of a future physical education teacher at a pedagogical university has its own specific characteristics, depending on the chosen specialty. The content of this training includes the implementation of an integrated pedagogical process aimed at nurturing the physical culture of an individual. This requires an expanded interpretation of the content of pedagogical education and the identification of components of readiness for professional activity: motivational, theoretical and practical-creative. Each of these components performs certain functions and is relatively independent. The motivational component is responsible for the desire for professional growth, the theoretical component is responsible for mastering knowledge and skills, and the practical-creative component is responsible for the application of this knowledge in practice. Such a structure provides the opportunity to implement various types of professional and pedagogical activity. The problem of defining the essential characteristics of a physical education teacher's readiness for professional activity is not new, but there is no single interpretation. It is often identified with other categories, such as preparedness, competence and professionalism. These characteristics determine the requirements for the teacher's personality and his/her work activity. The results of this study are of practical importance, since their theoretical provisions create the prerequisites for the scientific substantiation of the training of future physical education teachers. This includes the implementation of a holistic pedagogical process of developing students' physical education, which is relevant in the context of modern educational requirements.
Education of Patriotism, Justice, Creativity of Students Through Teaching Labor Poems of the Poet Alykul Osmonov
Authors: Murzaev N.
Published: February 2025

The work of the great poet of the Kyrgyz people Alykul Osmonov is aimed at the love of the Motherland, the glorification of the labor of workers. With such poems, he educated the reader in the patriotic spirit of diligence and justice. To glorify heroism, purity, and justice, we need not only a sharp pen and masterful talent, but above all, the purity and justice of the poet's heart. Then he will be able to really get to know such a pure, fair person like him and appreciate his work. His poems reflect the purity and justice of the poet's soul. In particular, we can say that, like the poet himself, his main character is a man of this principle and adheres to this idea. The poet himself cannot expect justice from his characters if he is not pure and impartial. Not only the main character of Aosmonov's poem "the science of Rakman", but also the heroes of many of his other poems are conscientious, hardworking people. They do not attack or steal public property. Many contemporaries considered this poet to be A. The Ottomans mentioned that this is a quality inherent in the character and character of the Ottomans. Unfortunately, it would not be an exaggeration to say that this is a quality that currently does not exist in our society. In the article, we elaborated on the fact that when analyzing a poet's poem, it is important not only to express the character of the character, but also to reflect the character and human qualities of the poet.
Development of a Manufacturing Process Kuraka “Turna”
Authors: Kamilzhankyzy K. , Arziev M. , Abdykalykova N.
Published: February 2025

The article examines the technology of making national artistic patchwork products of the Kyrgyz people, and the technology of making “kurak" has been developed. The technological sequence of the production process of kurak “turna" has been created. The possibility of providing meaning to patchwork products with the help of types of dried apricots and their structure is demonstrated.