bluuebunny/crossref_metadata_2025 huggingface dataset:
Assessment of CLA+T-cell subpopulations in the blood of patients with chronic dermatoses
Authors: Patrushev Alexander V. , Samtsov Alexey V. , Nikitin Vladimir Yu. , Soukharev Alexey V. , Gumilevskaya Oksana P. , Sukhina Irina A.
Published: November 2020

Background. CLA+T-cell are an important component of skin-associated lymphoid tissue, and thus determine the pathogenesis of many immuno-mediated dermatoses.
Aims. Determine the relative number of CLA+T-cell subpopulations in the peripheral blood of patients with psoriasis, lichen planus and atopic dermatitis, as well as assess their impact on the severity of dermatoses.
Materials and methods. We examined 82 patients with psoriasis aged 19 to 62 years, 54 patients with lichen planus (LP) aged 18 to 54 years, 44 patients with atopic dermatitis (AD) aged 18 to 44 years, as well as 20 practically healthy individuals aged 18 to 52 years who were admitted to the clinic for the removal of benign skin neoplasms.
All patients underwent a standard clinical examination with the determination of indicators that characterize the severity of dermatosis: PASI (Psoriasis Area and Severity Index) for patients with psoriasis, IPSLP (index of prevalence and severity of lichen planus) for patients with lichen planus and SCORAD (Scoring of Atopic Dermatitis) for patients with atopic dermatitis. Defining subpopulations CLA+T-lymphocytes were carried out on a flow cytometer Cytomics FC500 by Beckman Coulter using appropriate combinations of direct monoclonal antibodies and isotopic controls. The groups were compared using the nonparametric Mann Whitney test, and the differences were considered significant at p0,05. To analyze the relationship between the severity of dermatosis and the relative content of subpopulations CLA+T-cells used Spearman's rank correlation coefficient.
Results. In patients with psoriasis, a significant increase in the percentage of the total number of T-lymphocytes positive for CLA (CLA+CD3+) and T-helpers positive for CLA (CLA+CD4+) (p=0,002 and 8,5104, respectively), in patients with PL and AD only CLA+CD4+ lymphocytes (p=0,028 and 0,003, respectively). In the progressive period of psoriasis, a direct moderate correlation was found between the circulating subpopulation of cytotoxic T lymphocytes positive for CLA (CLA+CD8+) and the PASI index (rs=0,47; p0,001), in the acute period of AD between the CLA+CD3+ subpopulations and CLA+CD4+ cells and the SCORAD index (rs=0,53; p 0,001 and rs=0,57; p0,001, respectively). In PL, the severity of the course of dermatosis was not accompanied by any significant changes in the CLA-positive T-cell subpopulations.
Conclusion. The results of the study confirmed the important role of CLA+T cell subpopulations in the development of chronic dermatoses. In all groups (psoriasis, LP and AD), an increase in the relative number of CLA+CD4+ T-helpers was noted compared with the control group. The relationship between the severity of psoriasis and the relative number of CLA+CD8+ cytotoxic T-lymphocytes, and the severity of AD with CLA+CD3+ and CLA+CD4+ T-helpers is also shown.
Disease of the island of Meleda or keratoderma of Meleda
Authors: Abduvaxitova Indira N. , Toxtayev G’ayratillo Sh. , Safarov Kholikjon Kh.
Published: November 2020

Keratoderma is a group of dermatoses characterized by a violation of keratinization processes, excessive horn formation mainly in the area of the palms and soles. Under our supervision in the Tashkent regional skin and venereal clinic in the Department of dermatology was a patient Z. born in 2007, who was undergoing inpatient treatment for Meleda island disease. The rash is localized in the area of the palm and soles, changes and dystrophy of the nails. As a result of inpatient treatment (12 days), the Horny layers on the palms and soles decreased, especially in the Central part. All the cracks have fused, no new ones have been found. The severity of inflammatory phenomena, hyperkeratotic layers decreased, the area of the lesion and the intensity of itching decreased. The patient was discharged from the hospital with clinical improvement. This case is of particular interest to practical dermatovenerologists as a rare dermatosis
Current challenges and controversies surrounding SARS-CoV-2 immunity and their implications on reinfection, plasma therapy treatment outcomes, and vaccine development
Authors: Rao Vishal , Kannan Swetha , Subhash Anand , Arakeri Gururaj , Gulia Ashish
Published: November 2020

The global pandemic of coronavirus disease 2019 (COVID-19), caused by novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), was recognized using of next-generation sequencing. The pandemic is associated with respiratory distress syndrome, hyperinflammation, and high mortality making it a major public health concern. It is essential to explore the pathogenetic pathways to conclude a definite therapeutic approach. However, the crisis of the COVID-19 pandemic altered the equilibrium between waiting for substantiating results before determining whether to use the therapy or generating evidence during regular patient care, in support of the second choice. This review describes various key controversies and challenges of SARS-CoV-2 immunity, convalescent plasma therapy, and treatment outcomes. It further highlights the emerging vaccine therapy and future strategies for the treatment of COVID-19.
Recreational use of synthetic cannabinoids: prevalence, intoxication, side effects, addictive potential
Authors: Анцыборов А.В. , Камплицкая О.В. , Овсянников М.В. , Стадник К.В. , Панченко Л.Ф.
Published: November 2020

С появлением на нелегальном рынке наркотиков новых психоактивных веществ, одно из первых в данном классе стали занимать синтетические каннабиноиды (СК). СК в основном распространяются через сеть Интернет, с помощью онлайн мессенджеров, и VPN-сетей. Токсическое влияние СК на организм человека оказывается достаточно мощным и нередко заканчивается летальным исходом. Однако аддиктивный потенциал СК достаточно высок, и нуждается в дальнейшем изучении, особенно с появлением новых классов СК. Разработка дифференциально-диагностических критериев и терапевтических подходов при лечении острых психотических состояний, вызванных употреблением СК, представляется актуальной задачей для практического здравоохранения. Цель: обзор накопленных научных данных о последствиях рекреационного употребления СК на организм человека. Материалы: при написании обзора использовали следующие репрезентативные базы данных: PubMed, Google Scholar, Embase, Cochrane, платформы SciFinder, и Scopus. Методы: в качестве поисковых запросов использовались следующие ключевые слова: Spice, K2, synthetic cannabis, new psychoactive sub-stances (NPS), adverse effects, cannabinoid’s receptor, psychosis due to the use NPS, fatalities. Реферируемые статьи были отфильтрованы по тезисам, с целью определения релевантности для настоящего обзора.

With the emergence of novel psychoactive substances in the illegal drug market, synthetic cannabinoids (SCs) became one of the first in this class. SCs are mainly distributed through the Internet, by online messengers and VPN networks. The toxic effect of SCs on the human body is quite powerful and often results in death. The addictive potential of SCs is rather high and needs further study, especially with the emergence of new SC classes. Development of differential diagnostic criteria and therapeutic approaches in the treatment of acute psychotic conditions caused by the use of SCs is an urgent task for practical health care. Objective: to review scientific data on consequences of the recreational use of SCs in humans. Materials: data from six representative databases, PubMed, Google Scholar, Embase, Cochrane, the SciFinder platform, and Scopus, were used for this review. Methods: the following combinations and keywords were used as search queries: Spice, K2, synthetic cannabis, novel psychoactive substances (NPS), adverse effects, cannabinoid’s receptor, psychosis due to the use of NPS, fatalities. Peer-reviewed articles were filtered by abstracts to determine their relevance for the present review.
Adenoma hipofisário secretor de TSH: uma revisão sistemática / TSH-secreting pituitary adenoma: a systematic review
Authors: Souza Paulyanara Monique Alves de , Morais Jefferson Ricardo Rodrigues , Morais Karla Vanessa Rodrigues , Brito Josué Da Silva , Faria Talitha Araújo
Published: November 2020

Introdução: Os adenomas hipofisários são tumores caracterizados pela proliferação de células adeno-hipofisárias produtoras de hormônios tróficos. Dentre eles, os adenomas hipofisários produtores de TSH (TSHomas), neoplasias benignas pouco frequentes, que correspondem a menos do que 3% dos adenomas hipofisários. Método: Pesquisamos os termos TSHomas, tireotropinomas e adenomas pituitários secretores de TSH nas bases Pubmed, Lilacs e Scielo. Incluímos artigos publicados entre 2010 e 2020, sendo excluídos relatos de casos, artigos indisponíveis e que não tratavam sobre o tema. Resultados e discussão: Os TSHomas são tumores fibrosos, monoclonais, com incidência entre 0,015 a 0,03 casos/100.000 habitantes, que se manifestam por hipertireoidismo e sintomas causados por efeito de massa. São diagnosticados diante da elevação de TSH juntamente a hormônios tireoidianos, na presença de alterações neurorradiológicas. O tratamento de primeira escolha consiste na neurocirurgia transesfenoidal, sendo os análogos de somatostatina e a radioterapia alternativas para o manejo de pacientes em que a intervenção cirúrgica é desaconselhada. Conclusão: Os TSHomas são raros, contudo, precisam ser investigados diante da secreção inadequada de TSH.Palavras chave: Adenoma, Hormônios tireoidianos, Neoplasias hipofisárias, Síndrome da secreção inadequada de TSH, Hipertireoidismo centralABSTRACTIntroduction: Pituitary adenomas are tumors characterized by the proliferation of adenohypophysis cells that produce trophic hormones. Among them, TSH-producing pituitary adenomas (TSHomas), uncommon benign neoplasms, whichcorrespond to less than 3% of pituitary adenomas. Method: We searched for the terms TSHomas, thyrotropinomas and pituitary adenomas secreting TSH in the Pubmed, Lilacs and Scielo databases. We included articles published between 2010 and 2020, excluding case reports, articles that were unavailable and did not deal with the topic. Results and discussion: TSHomas are fibrous, monoclonal tumors, with an incidence of 0.015 to 0.03 cases / 100,000 inhabitants, which are manifested by hyperthyroidism and symptoms caused by a mass effect. They are diagnosed with elevated TSH along with thyroid hormones, in the presence of neuroradiological changes. The first-choice treatment consists of transsphenoidal neurosurgery, with somatostatin analogs and radiotherapy being alternatives for the management of patients in whom surgical intervention is not recommended. Conclusion: TSHomas are rare, however, they need to be investigated due to inadequate TSH secretion.Keywords: Adenoma, Thyroid hormones, Pituitary neoplasms, Inappropriate TSH secretion syndrome, Central hypothyroidism
SAMPL7 Host-Guest Challenge Overview: Assessing the reliability of polarizable and non-polarizable methods for binding free energy calculations
Authors: Amezcua Martin , El Khoury Léa , Mobley David
Published: November 2020

The SAMPL challenges focus on testing and driving progress of computational methods to help guide pharmaceutical drug discovery. However, assessment of methods for predicting binding affinities is often hampered by computational challenges such as conformational sampling, protonation state uncertainties, variation in test sets selected, and even lack of high quality experimental data. SAMPL blind challenges have thus frequently included a component focusing on host-guest binding, which removes some of these challenges while still focusing on molecular recognition. Here, we report on the results of the SAMPL7 blind prediction challenge for host-guest affinity prediction. In this study, we focused on three different host-guest categories -- a familiar deep cavity cavitand series which has been featured in several prior challenges (where we examine binding of a series of guests to two hosts), a new series of cyclodextrin derivatives which are monofunctionalized around the rim to add amino acid-like functionality (where we examine binding of two guests to a series of hosts), and binding of a series of guests to a new acyclic TrimerTrip host which is related to previous cucurbituril hosts. Many predictions used methods based on molecular simulations, and overall success was mixed, though several methods stood out. As in SAMPL6, we find that one strategy for achieving reasonable accuracy here was to make empirical corrections to binding predictions based on previous data for host categories which have been studied well before, though this can be of limited value when new systems are included. Additionally, we found that alchemical free energy methods using the AMOEBA polarizable force field had considerable success for the two host categories in which they participated. The new TrimerTrip system was also found to introduce some sampling problems, because multiple conformations may be relevant to binding and interconvert only slowly. Overall, results in this challenge tentatively suggest that further investigation of polarizable force fields for these challenges may be warranted.
Thermodynamic Decomposition of Solvation Free Energies with Particle Mesh Ewald and Long-Range Lennard-Jones Interactions in Grid Inhomogeneous Solvation Theory
Authors: Chen Lieyang , Cruz Anthony , Roe Daniel R. , Simmonett Andrew , Wickstrom Lauren , Deng Nanjie , Kurtzman Tom
Published: November 2020

Grid Inhomogeneous Solvation Theory (GIST) maps out solvation thermodynamic properties on a fine meshed grid and provides a statistical mechanical formalism for thermodynamic end-state calculations. However, differences in how long-range non-bonded interactions are calculated in molecular dynamics engines and in the current implementation of GIST have prevented precise comparisons between free energies estimated using GIST and those from other free energy methods such as thermodynamic integration (TI). Here, we address this by presenting PME-GIST, a formalism by which particle mesh Ewald (PME) based electrostatic energies and long-range Lennard-Jones (LJ) energies are decomposed and assigned to individual atoms and the corresponding voxels they occupy in a manner consistent with the GIST approach. PME-GIST yields potential energy calculations that are precisely consistent with modern simulation engines and performs these calculations at a dramatically faster speed than prior implementations. Here, we apply PME-GIST end-states analyses to 32 small molecules whose solvation free energies are close to evenly distributed from 2 kcal/mol to -17 kcal/mol and obtain solvation energies consistent with TI calculations (R2 = 0.99, mean unsigned difference 0.8 kcal/mol). We also estimate the entropy contribution from the 2nd and higher order entropy terms that are truncated in GIST by the differences between entropies calculated in TI and GIST. With a simple correction for the high order entropy terms, PME-GIST obtains solvation free energies that are highly consistent with TI calculations (R2 = 0.99, mean unsigned difference = 0.4 kcal/mol) and experimental results (R2 = 0.88, mean unsigned difference = 1.4 kcal/mol). The precision of PME-GIST also enables us to show that the solvation free energy of small hydrophobic and hydrophilic molecules can be largely understood based on perturbations of the solvent in a region extending a few solvation shells from the solute. We have integrated PME-GIST into the open-source molecular dynamics analysis software CPPTRAJ.
Electrostatically Tuning the Photodissociation of the Irgacure 2959 Photoinitiator in the Gas Phase by Cation Binding
Authors: Marlton Samuel , McKinnon Benjamin I. , Hill Nicholas , Coote Michelle , Trevitt Adam
Published: November 2020

Our paper reports a combined experimental and computational investigation of the electrostatic tuning of Irgacure 2959, a Norrish-type I photoinitiator, in the presence of bound cations (H+ , Li+ , Na+ , K+ , Zn2+ , Ca2+ and Mg2+). Laser photodissociation action spectroscopy is deployed to acquire photodissociation spectra of mass- selected cation complexes. Quantum chemical calculations (TD-DFT and SCS-CC2) reveal that the cations are acting as point charges such that shifts of the key ππ* and nπ* states can be modelled as perturbations by an oriented electric field (OEF). The model agrees with the experimental photodissociation action spectra.
Augmented Lagrangian Method for Optimizing Non-Orthogonal Orbitals
Authors: Sumita Masato , Yoshikawa Naruki
Published: November 2020

We applied augmented Lagrangian method to optimize molecular wave function based on non-orthogonal orbitals (Spin coupled wave function; SCWF) for its grand-state energy. In contrast to the orthogonal-orbital-based electronic structure theory, SCWF includes spin eigenfunctions to satisfy the eigen states as the operator of the square of the spin. To obtain the ground-state energy of SCWF, therefore, it is necessary to optimize the orbital and the spin-coupling coefficients simultaneously. In this study, the spin-coupling and the orbital coefficients are optimized with the augmented Lagrangian method under the constrain of normality of the wave function.We employed this SCWF method to compute dissociative potential energy surfaces (PESs) of H2, H2-, He2+, and HLi. The obtained PESs by the SCWF method are close to these by full configuration interaction theory. These results indicate that the augmented Lagrangian method is effective to optimize SCWF.
Switch Chemistry at Cryogenic Conditions: Quantum Tunnelling under Electric Fields
Authors: Kirshenboim Omer , Frenklah Alexander , Kozuch Sebastian
Published: November 2020

While the influence of intramolecular electric fields is a known feature in enzymes, the use of oriented external electric fields (EEF) to enhance or inhibit molecular reactivity is a promising topic still in its infancy. Herein we will explore computationally the effects that EEF can provoke in simple molecules close to the absolute zero, where quantum tunnelling (QT) is the sole mechanistic option. We studied three exemplary systems, each one with different reactivity features and known QT kinetics:  bond-shifting in pentalene, Cope rearrangement in semibullvalene, and cycloreversion of diazabicyclohexadiene. The kinetics of these cases depdend both on the field strength and its direction, usually giving subtle but remarkable changes. However, for the cycloreversion, which suffers large changes on the dipole through the reaction, we also observed striking results. Between the effects caused by the EEF on the QT we observed an inversion of the Arrhenius equation, deactivation of the molecular fluxionality, and stabilization or instantaneous decomposition of the system. All these effects may well be achieved, literally, at the flick of a switch.
Synchronizing Gas Injections and Time-Resolved Data Acquisition for Perturbation-Enhanced APXPS Experiments
Authors: Redekop Evgeniy , Johansson Niclas , Kokkonen Esko , Urpelainen Samuli , Lopes da Silva Felipe , Olsbye Unni
Published: November 2020

An experimental approach is described in which well-defined perturbations of the gas feed into an Ambient Pressure X-Ray Photoelectron Spectroscopy (APXPS) cell are digitally synchronized with time-resolved XPS data acquisition with a Delay Line Detector (DLD). These experiments unlock new possibilities for investigating the properties of materials and chemical reactions mediated by their surfaces, such as those in heterogeneous catalysis, surface science, and coating/deposition applications. Implementation of this approach, which is termed perturbation-enhanced APXPS, at the SPECIES beamline of MAX-IV Laboratory is discussed along with several experimental examples including (1) individual pulses of N2 gas over Au foil, a multi-pulse titration of oxygen vacancies in a pre-reduced TiO2 single crystal with O2 gas, and a sequence of alternating precursor pulses for Atomic Layer Deposition (ALD) of TiO2 on a silicon wafer substrate.
Cinnoline Derivatives as Antibacterial Agent and Antimycobacterial Agent: Synthesis, Microbial Evaluation and Molecular Docking Study
Authors: Prashanthi Evangeline M  , Prem Kumar P  , Bala Murugan K
Published: November 2020

Fourteen Novel cinnoline library compounds were designed, synthesized through a facile approach, and allowed for screening for anti-bacterial activity and anti-tubercular activity. The titled compounds were entirely synthesized by replacing alkyl groups, sulphonyl, halo groups in the 6th & 7th position of cinnoline moiety. The enlightenment of structure was done by FTIR HNMR along with elemental analysis and further docked for Structural activity. The newly synthesized Cinnoline Compounds were examined for their in vitro drug-sensitive M tuberculosis H37Hv strain. All the compounds have shown MIC between >100-12.5 μg /ml. In this investigation, we Evaluated all the compounds for Anti-bacterial activity. The main compounds were initially tested in vitro for Anti-bacterial activity against gram-positive and gram-negative bacteria by using the Disk plate method. The most active Compound 10 exhibited 12.5 μg /ml inhibitions against drug-sensitive M Tuberculosis H37Rv strain. Among all synthesized compounds CN-7 was found to be a Hit compound with MIC value 12.5 ug/ml Against E Coli.
Development and formulation of itraconazole capsule by using reliable dispersion technique for solubility enhancement
Authors: Anuj Kumar  , Chirag Chugh  , Sachin Chaudhry
Published: November 2020

Solid dispersions enhance the bioavailability and dissolution rate of the drugs by increasing the solubility of low soluble drugs. Different methods are employed in the preparation of Solid Dispersions such as kneading technique, co-precipitation technique, hot-melt extrusion technique, fusion technique, solvent technique, etc. Solid Dispersions has used various types of carriers to enhance the solubility of low soluble drugs. In this paper to overcome the drawback of adaptive solid diffusion methods and also to recover the bioavailability of itraconazole without crystalline change, we have used the following itraconazole, poloxamer, Sporanox, citric acid and PVP to prepare the solid diffusions. Itraconazole, poloxamer, Sporanox chemical are supplied by the various chemical supplier like Hemmi Pharma, BASF Chemical, Korea-Hanssen Pharm respectively. Solid diffusion the properties of carters on the solubility of itraconazole has experimented. Also, the dissolution and stability have been investigated and evaluated with commercial chemicals such as Sporanox which consist of 100 mg itraconazole. Hence it is crucial to show the changes in a crystalline form of the drug for a minimum of 6 months to shows the stability of the presented dispersion approach. Thus, developed formulation shows the importance of solubility without crystalline change by improving the bioavailability and increased the solubility of the drug.
Role of Rasayan Churna in outbreak of Covid -19 as preventive and curative aspect
Authors: Amol Madhav Deshpande  , Mayuri Amol Deshpande
Published: November 2020

In last two decade world suffer with three epidemic diseases like SARS-CoV, H1N1 influenza, MERS –CoV and presently the world under a pandemic of Covid-19, out of these SARS-CoV, MERS –CoV and Covid-19 are form the same virus call as corona, which primary present on bats and transferred from animal to human, and then it transfer from human to human mostly by respiratory droplets or in the direct contact with the diseased person, these recurrent infection of corona virus is the burning issue in the word, so to avoid these recurrent infections good habitual behaviour with regular immune booster medicine should be taken which can be used in both normal and symptomatic patient for this Rasayan churna  is the best drug of choice as it is used for  rejuvenation therapy. From literally study from various recourses it is found that Rasayan churna have property anti-depressant, anti-xylotic, Immunomodulatory, Anti-diabetes, anti hypertensive, anti-inflammatory, Anti-toxic effects, Anti-arthritic, Anti-cancer effects, Anti-microbial effect, and Anti-oxidant which can be useful in preventive aspect of Covid -19 in all phase like normal individual, also can be used in asymptomatic patients and symptomatic patients, clinical study can be performed for the same to evaluate the result.
Possible effects of Ayurvedic herbs on management of COVID-19
Authors: Ajayratna Anandrao Meshram  , Srihari S  , Shweta Parwe
Published: November 2020

Corona virus disease COVID-19 is caused by coronavirus that can spread between animals and humans. The most common symptoms are fever, tiredness, and dry cough. Some individuals also develop aches and pains, nasal congestion, runny nose, sore throat, or diarrhoea. It was reported that traditional remedies may alleviate the symptoms of COVID-19. However, a major drawback is a lack of adequate scientific basis. Tulsi has multi-modal therapeutic effects, we hypothesize that Tulsi may be effective in the prevention and management of COVID-19. Though the existing literature supports the management of symptoms of COVID-19 using Tulsi, a lack of standard formulation limits its use. This is the need of time to start with translational research to provide scientific evidence for the efficacy and to establish the standard formulation of Tulsi in the management of COVID-19. Taking these things in to consideration efforts have been made to treat the patients of COVID-19 with Shaman Therapy Herbal Formulations. On the basis of findings and observations obtained after completion of current project it can be concluded that covid19 are progressive degenerative conditions in which Tridosha at its own Ashaya gets provoked and as it belongs to Madhyam Rogamarga treatment becomes challenging. This attempt possibly finds solutions which can prevent. Ayurveda the features like cough, running of nose & sore throat are caused due to Dushti (vitiation) of Pranavaha Srotas & also having Annavaha Strotas Dushti & Rasavaha Strotas Dushti. Ayurveda is the world’s oldest medical system that can manage any disease without side effects.
Healthcare workers novel coronavirus (nCOVID 19) life-threatening situation during the pandemic
Authors: Shweta Dadarao Parwe  , Avinash Sukhdeorao Ingle  , Milind Abhimanyu Nisargandha  , Bharat Rathi
Published: November 2020

Healthcare workers (HCWs) are the professional workers directly acquired infection during this coronavirus outbreak. Coronavirus potentially severe acute respiratory infection caused by nCOVID-19 has been declared by pandemic on 11th March 2020 by Word health organisation (WHO). The previous study has reported high susceptibility of respiratory infection in the HCWs. The HCWs are at increased risk for severe respiratory syndrome coronavirus infection. The spread of coronavirus became global public health event, threatening physical and Mental Health of HCWs. This study reviews the possible risk factors for being infected HCWs and avoid transmission of infection at the workplace. Spreading the coronavirus day by day is the life-threatening condition for Health care workers during a pandemic. The community should understand the HCW’s increased responsibility during this public health emergency and must provide the necessary social support as well. There should be enough protective and preventive measures for avoiding transmission in HCWs. Apart from heavy duties HCWs while using PPEs they also have physical and mental exhaustion along with the fear produced out of risk-specific exposures.
Evde Sağlık Hizmetlerinde İnformal Bakım Verenlerin Bilgi ve Beceri Düzeyinin Belirlenmesi
Authors: GÜDÜK Özden , GÜDÜK Özlem , SERTBAŞ Yaşar
Published: November 2020

Amaç: Evde sağlık hizmetlerinden yararlanan hastaların yakınlarının bilgi ve beceri durumunun değerlendirilmesidir.
Materyal ve Metot: 2019 yılı Ocak-Mart ayları arasında ziyaret edilen 616 hastanın yakınına ulaşılmıştır. Araştırmacılar tarafından literatür taraması ile oluşturulan anket uygulanmıştır. Analizlerde SPSS Statistics 22 programı kullanılmıştır.
Bulgular: Bakım verenlerin %74,2’si 34-65 yaş grubunda ve %84,4’ü kadındır. Katılımcıların %63’ü hastanın
birinci derece akrabası olup, %44,9’u ilköğretim okulu ve altında eğitim seviyesine sahiptir. Bakım verenlerin %85’i hasta bakımı konusunda eğitim almadığını ifade etmiştir. Hastaların %46,5’inin tam bağımlı olduğu ve %20,8’inde dekübit ülseri geliştiği saptanmıştır. Katılımcıların yarısı (%50,5) 3 yıldan daha az süredir bakım vermekte, % 69,2’si gün içinde 17-24 saat arası bakım görevini üstlenmektedir. Bakım verenin bir ay içerisinde hasta bakımı yapmaksızın kendisine ayırdığı gün ortalaması 2,24 (±4,77)’ bulunmuştur. Bakım verenlerin tıbbi cihazların kullanımı, bakımı, temizliği ve arızalanması durumunda yapılacaklar konusunda bilgilerinin az olduğu görülmüştür. Hastanın uyması gereken diyeti, kullandığı ilaçlar ve hijyen bakımı ile ilgili ifadelerin en yüksek bilgi düzeyine sahip olduğu görülmüştür. Bakım verenin eğitim seviyesi, yaşı, hastaya bakım verdiği süre ve daha önce başka bir hastaya bakım vermiş olma durumunun sahip olduğu bilgi/beceri üzerine etkili olduğu bulunmuştur.
Sonuç: Hasta yakınlarının bilgi ve beceri düzeyinin yükseltilmesi, hastanın alacağı bakımın kalitesini yükseltecek ve hastayı olumsuz sağlık koşullarından koruyacaktır.
Karpal Tünel Sendromu Tanılı Erkek Olguların Klinik ve Elektrofizyolojik Bulgularının Meslek Hastalığı, Obezite ve Sigara Kullanımıyla İlişkisinin Değerlendirilmesi
Authors: ÜSTÜN ÖZEK Sibel , EMİR Canan , İNAN Rahşan Adviye
Published: November 2020

Amaç: Bu çalışmada elektrofizyolojik olarak karpal tünel sendromu (KTS) tanısı almış erkek olgularda sigara kullanımı, obezite, yaş, meslek ve meslek süreleri ile KTS ilişkisinin araştırılmasını amaçladık.
Materyal ve Metot: Çalışmaya KTS tanısı konulan 50 erkek olgu dahil edildi. Hastaların yaşı, semptom süreleri, el dominansları, meslekleri ve meslek süreleri, sigara kullanımları ve vücut kitle indeksi (VKİ) kaydedildi. Semptom şiddeti Boston semptom şiddet skalası (BSŞS) ve fonksiyonel kapasite skorları (FKS) ile değerlendirildi. Elektrofizyolojik değerlendirmede bilateral ulnar median duysal ve motor sinir ileti incelemeleri çalışıldı.
Bulgular: Hastaların yaş ortalaması 48,40±9,61 yıldı. Mesleki dağılımları büyük oranda inşaat, tekstil, ayakkabı işçileri ve aşçılardan oluşturmaktaydı. BSŞS ortalaması 22,88±8,385 ve FKS 11,40±4,527 idi. VKİ <25 ile >25 üzeri olan KTS’lı hastaların yaş, semptom süresi, semptom şiddet ve FKS arasında istatistiksel olarak anlamlı fark saptanmadı. Meslek süreleri ve sigara kullanımıyla hastalık şiddeti arasında bir ilişki saptanmadı.
Sonuç: Erkek KTS özellikle tekstil, inşaat işçileri,ayakkabı üreticileri ve aşçılar gibi işçi sınıfında yüksek oranda görülür. Obezite dereceleri ve sigara kullanımıyla hastalık şiddeti arasında anlamlı ilişki saptamamakla birlikte daha büyük vaka serileri üzerinde çalışmak gereklidir. Çalışanların KTS ile ilgili bilinçlenmesi ve meslek hastalığı farkındalığının oluşturulması önemlidir.
Characterization of ori and parS-like functions in secondary genome replicons in Deinococcus radiodurans
Authors: Maurya Ganesh K , Misra Hari S
Published: November 2020

The mechanisms underlying multipartite genome maintenance and its functional significance in extraordinary radioresistance of Deinococcus radiodurans are not well understood. The sequences upstream to parAB operons in chrII (cisII) and MP (cisMP) could stabilize an otherwise, non-replicative colE1 plasmid, in D. radiodurans. DnaA and cognate ParB proteins bound specifically with cisII and cisMP elements. The ΔcisII and ΔcisMP cells showed the reduced copy number of cognate replicons and radioresistance as compared with wild type. Fluorescent reporter–operator system inserted in chrI, chrII, and MP in wild type and cisII mutants showed the presence of all three replicons in wild-type cells. Although chrI was present in all the ΔcisII and ΔcisMP cells, nearly half of these cells had chrII and MP, respectively, and the other half had the reduced number of foci representing these replications. These results suggested that cisII and cisMP elements contain both origin of replication and parS-like functions and the secondary genome replicons (chrII and MP) are maintained independent of chrI and have roles in radioresistance of D. radiodurans.
Integrasi E-Servqual, Model Kano, dan HOQ dalam Meningkatkan Kepuasan Pelanggan Jasa Ojek Online
Authors: Kosasih Wilson , Sriwana Iphov Kumala , Adhesi Rico
Published: November 2020

Online motorcycle taxi service providers become business opportunities that grow and develop. The development of digital business opportunities is also supported by the increasingly widespread service users. This research aims to determine the characteristics of online motorcycle taxi service users and the attributes that are priority for users. In this study, several methods are used and integrated include: e-ServQual, IPA (importance-performance analysis), Kano Model, and House of Quality. The measurement result of the consumer satisfaction index is 55.58%, meaning that the consumers are quite satisfied with the online service. Based on the findings of this study, the attributes prioritized by consumers are the punctuality of the driver's arrival as stated in the application (attribute 14), the driver confirms the customer's order quickly (attribute 15), and the driver is easy to obtain (attribute 17). Finally, this study also recommends corrective actions to these service providers, among others: maintaining server reliability with a relative importance of 21.4%, regularly conducting driver training with a relative importance of 15.2%, and increasing the number of drivers with a relative importance 4.3%.
Implementation of Failure Mode and Effect Analysis and Fault Tree Analysis in Paper Mill: A Case Study
Authors: Nurwulan Nurul Retno , Veronica Wilcha Anatasya
Published: November 2020

A good quality control system is important to be implemented to increase productivity and minimize defects in products. One of the quality control methods is failure mode and effect analysis (FMEA). This study uses the FMEA to identify the causes of the defects and recommend the prevention methods to overcome the causes of the defects in an Indonesian paper mill. The risk priority number (RPN) is calculated by multiplying the severity, occurrence, and detection of the failures that have been determined. Unsymmetrical and tainted products are the most dominant defects in the paper mill. An inappropriate machine setting is the cause of unsymmetrical products with the highest RPN of 343. The second highest RPN is problems with bleaching machines that caused tainted products with an RPN value of 216. This study offers suggestions to Indonesian paper mill to prevent and minimize defective products.
Pendekatan FMEA dalam Analisa Risiko Perawatan Sistem Bahan Bakar Mesin Induk: Studi Kasus di KM. Sidomulyo
Authors: Yaqin Rizqi Ilmal , Zamri Zamri Zamri , Siahaan Juniawan Preston , Priharanto Yuniar Endri , Alirejo M. Subroto , Umar Mega Lazuardi
Published: November 2020

The fuel system is one of the main engine support systems which is very important in the operation of the KM Sidomulyo main engine. Main engine on ships are operated 24 hours a week or more. The operation main engine needs special treatment of the components on the main engine to prevent failure during operation. Failure Mode and Effect Analysis (FMEA) is a method that can be used to identify the priority scale in maintaining a machine by evaluating the risk of failure that occurs on the machine. This study applies FMEA to determine the priority scale for the maintenance of the KM Sidomulyo main engine fuel system. The results of the identification using FMEA, namely the injector and fuel filter components are components that must be prioritized for maintenance. The Risk Priority Number (RPN) values of the injector and fuel filter components are 192 and 168, respectively. Maintenance priority is based on the component RPN value is above the critical RPN value of the main engine fuel system and includes the priority component on the Pareto diagram. The type of maintenance applied to the injector component is checking dirty fuel which can cause the injector to operate less optimally. While the fuel filter component is cleaning the deposits on the fuel filter cartridge. It is recommended that the inspection of other components be carried out so that the condition of the main engine fuel system has good reliability.
Out-of-hospital cardiac arrest in countries of the Gulf Cooperation Council: a scoping review
Authors: Batt Alan , Lanos Chelsea , Delport Shannon , Al-Hasan Dalal , Knox Shane , Alhmoudi Assim , Anderson Megan , Fares Saleh , Cummins Fergal
Published: November 2020

Background: Published data are lacking on response to and outcomes of out-of-hospital cardiac arrest in the Middle East. What data there are have not been comprehensively analysed. Aims: This study aimed to assess the characteristics of people with out-of-hospital cardiac arrest in Gulf Cooperation Council (GCC) countries (Bahrain, Kuwait, Oman, Qatar, Saudi Arabia and United Arab Emirates) and the response to and outcomes of such incidents. Methods: This was a scoping review of published and grey literature on out-of-hospital cardiac arrest in GCC countries from 1990 to June 2019. Studies in English and Arabic were eligible for inclusion. MEDLINE, CINAHL, Web of Science and EMBASE were searched as well as relevant non-indexed journals. Google searches were also done. References of included studies were scanned for relevant articles. Experts on the subject in the region were consulted. Results: Of 647 citations retrieved, 24 studies were included for data extraction and analysis. No literature was identified for Bahrain. People with out-of-hospital cardiac arrest in the region were younger, predominantly male and had more comorbidity than reported in other regions of the world. Use of emergency medical services was low across the GCC countries, as was bystander cardiopulmonary resuscitation, return of spontaneous circulation and survival to discharge. Conclusions: A coordinated effort to address out-of-hospital cardiac arrest, including the generation of research, is lacking within and among GCC countries. Establishment of lead agencies responsible for developing and coordinating strategies to address out-of-hospital cardiac arrest, such as community response, public education and reporting databases, is recommended.
Penerapan Kepemimpinan Melayani (Servant Leadership) Bidang Penguatan Karakter Guru dan Siswa
Authors: Rahayu Sri Wening , Benyamin Conny
Published: November 2020

Abstrak: Penelitian ini difokuskan pada permasalahan antara lain: (1) nilai-nilai yang mendasari kepemimpinan pelayanan atau servant leadership (2) penerapan kepemimpinan pelayanan atau servant leadership dan (3) dampak penerapan kepemimpinan pelayanan atau servant leadership terhadap karakter guru dan siswa  di SD Shinning Star  Malang dan SD Aletheia Malang. Penelitian ini  menggunakan pendekatan Penelitian kualitatif, tipe deskriptif, dengan jenis  penelitian studi multi situs. Teknik pengumpulan data yang digunakan adalah wawancara mendalam, observasi partisipan dan dokumentasi.  Subyek penelitiannya adalah kepala sekolah, guru, orang tua dan pengurus yayasan. Teknik keabsahan data yang digunakan adalah  kredibilitas,diskusi dengan teman sejawat, member chek, dependabilitas dan konfirmabilitas.
Manajemen Layanan Transportasi Bus Sekolah di Kota Surabaya
Authors: Maghfiroh Nandha Putri
Published: November 2020

Penelitian ini didasari oleh fenomena kemacetan yang terjadi di Surabaya. Tujuan dari penelitian ini untuk mendeskripsikan dan menganalisis kecukupan peserta didik pada layanan transportasi bus sekolah, keselamatan peserta didik, serta efisiensi yang diberikan kepada peserta didik yang diberikan oleh pihak Dinas Perhubungan kota Surabaya untuk peserta didik yang menggunakan layanan transportasi bus sekolah. Penelitian ini menggunakan pendekatan kualitatif dengan metode deskriptif dan rancangan yang digunakan adalah penelitian studi kasus. Teknik pengumpulan data menggunakan teknik wawancara, observasi, dan dokumentasi. Analisis data dalam penelitian ini menggunakan kondensasi data, penyajian data, dan verifikasi data. Untuk pengecekkan keabsahan data dalam penelitian ini yakni menggunakan uji kredibilitas, transferabilitas, dependabilitas,dan konfirmabilitas. Hasil penelitian di Dinas Perhubungan kota Surabaya selaku pengelola layanan bus sekolah menunjukkan (1) kecukupan pada layanan transportasi bus sekolah dapat dilihat melalui kapasitas daya tampung serta fasilitas yang terdapat didalam bus sekolah; (2) keselamatan peserta didik pada layanan transportasi bus sekolah dapat dilihat melalui perawatan terhadap bus sekolah yang dilakukan oleh pihak Dinas Perhubungan kota Surabaya; (3) efisiensi yang akan diperoleh oleh peserta didik yang menggunakan layanan transportasi bus sekolah yang diberikan oleh pihak Dinas Perhubungan kota Surabaya.
Challenges and Opportunities after Working as Filipino Flight Attendants in Local Airlines: Input for an Empowerment Sessions for Tourism Management Students
Authors: Mahusay Sharon Candy Manguerra , Bantugan Brian Saludes
Published: November 2020

This study investigates the different challenges and opportunities encountered by Filipino flight attendants, who used to work with local airlines, to create empowerment sessions for tourism students who intend to be flight attendants but will later find themselves transferred to another field. The notion behind the empowerment sessions was guided by empowerment theories, in general. The researchers interviewed via an emailed list of questions guided by the research questions Filipino flight attendants who worked in a local airline until saturation was reached at five participants. The narratives from the participants were textually and thematically analyzed to surface themes relevant to successful career shifting among flight attendants. Focal areas of development were identified from the narratives and themes and mapped in a matrix aligning them with existing courses in the Tourism Management curriculum of St. Paul University Manila, and the relevance of those courses to flight attendants before, during, and after their career in the airline industry. The study found that there are different challenges awaiting flight attendants after they leave said careers. Some encountered the challenge of looking for other kinds of jobs in a different company, how to adjust to their new, and how to deal with new responsibilities in a different field as a supervisor or entrepreneur. The study identified ten focal areas of development that could be cultivated in empowerment sessions within existing General Education and major courses of the said degree program. The study recommends that the same mapping should be done in all programs to empower students from any discipline at any point during their formation in the university and to optimize the value of academic courses in the lives of students.
The Psychomotor and Cognitive Competencies of Filipino Children Ages 1-4: A Multiple Case Study
Authors: Arbiol Jennifer M. , Cabajes Angelie V. , Chaonui Maria Lila Y. , Mancao Pearl Ann M.
Published: November 2020

This multiple case study explored on the psychomotor and cognitive competencies of four Filipino children, ages one to four who came from different demographic background. This also determined other prominent psychomotor and cognitive competencies of these children not indicated in the NELC development standards (ECCD Council, 2015) and described relevant issues and concerns that impact their psychomotor and cognitive development using a researcher-developed early childhood development checklist and an interview guide for the children’s parents/guardians. The study was able to describe the psychomotor and cognitive competencies of four Filipino children based on the NELC development standards. There were specific psychomotor and cognitive competencies that were identified but not defined in the NELC standards, but they were recognized distinct to a child’s social context. Relevant environmental stimulations, especially, from primary caregivers were recognized as important determinants of children’s psychomotor and cognitive development. Furthermore, findings of the study conform to principles on child development and learning – that development proceeds at varying rates for each child and reflects children’s experiences and their environment. This implies that when planning programs and early learning experiences for children, individual and age appropriateness should be considered, and the child is understood as part of his/her environment. Further researches may explore other domains of development and other socio-cultural perspectives of development utilizing quantitative and qualitative research methodologies, which could involve bigger groups of children in different regions of the Philippines.
Sobrepeso / obesidad, adiposidad central como factores de riesgo cardiometabólico, parroquia Bayas 2019
Authors: Izquierdo Coronel Diana Carolina , Izquierdo Coronel Sebastián Alejandro , Guallpa Méndez Marcos Daniel , Argudo Vazquez Daniela Karolina
Published: November 2020

CONTEXTO: La obesidad, es una enfermedad crónica que constituye un problema de salud pública. OBJETIVO: determinar la prevalencia de sobrepeso, obesidad y adiposidad central como factores de riesgo cardiometabólico en la Parroquia Bayas 2019. DISEÑO DE ESTUDIO: cuantitativo-descriptivo-transversal. METODOLOGÍA la investigación incluyó una Muestra no probabilística por conveniencia representativa de 347 habitantes de ambos sexos y edades entre 20 y 64 años. Se clasificó el sobrepeso, obesidad y obesidad abdominal según los criterios de la organización Mundial de la Salud. RESULTADOS: El 66% de la población fueron menores de 45 años. El 55,9% fueron mujeres y el 44,1% varones. El 48,7% tuvieron sobrepeso, el 18,4% obesidad y el 76.4% adiposidad central. El sobrepeso y obesidad fue más prevalente en mujeres que en varones (70,1% vs 63,3% respectivamente) y el grupo etario más prevalente fue entre 45-54 años con el 84,2% mujeres y el 83,3% varones. La adiposidad central fue más prevalente en mujeres que en varones (87,1% vs 62,7% respectivamente) y el grupo etario con mayor prevalencia fue entre 45-54 años con el 78.9% hombres y el 97.6% mujeres. La adiposidad central estuvo presente en el 44,7% de los encuestados con índice de masa corporal normal, en el 89,3% de las personas con sobrepeso y en el 98,4% de los participantes con obesidad. CONCLUSIONES: Este estudio, ha permitido obtener datos reales con respecto a la prevalencia de sobrepeso, obesidad y adiposidad central; estos resultados servirán para establecer políticas de salud orientadas a fomentar su prevención y desarrollo de comorbilidades.