bluuebunny/crossref_metadata_2025 huggingface dataset:
Isochlorogenic acid B inhibits enterovirus 71 replication by upregating p53
Authors: Liu Ziwei , Wu Jingjing , Zhao Baotian , Zhang Qinyu , Zhao Hong , Jiao Haitao
Published: April 2024

：Objective To explore the role of p53 in the replication of
enterovirus 71 (EV71) and the anti-EV71 replication mechanism of
isochlorogenic acid B in extract of honeysuckle. Methods EV71
strain was isolated and inoculated with RD cells to detect virus titer,
CCK-8 to detect cell survival rate and LDH to detect cell damage rate.
RD cells were treated with RITA (p53 activator), Pifithin-α (p53
inhibitor) and isochlorogenic acid B, and the expressions of autophagy
related proteins p62, LC3, p53 and viral VP1 were detected by Western
Blot. Cell survival rate and cell damage rate were detected by CCK-8 and
LDH. Results EV71 strain was isolated and infected with RD
cells, the intracellular p53 content decreased, p62 and LC3II content
increased. In the RITA treatment group, p53 content increased, p62,
LC3II content decreased, virus titer decreased, cell survival rate
decreased, and damage rate increased. In Pifithin-α treatment group,
intracellular p53 content decreased, p62, LC3II content increased, virus
titer increased, cell survival rate decreased, and damage rate
increased. In isochlorogenic acid B treatment group, p53 content
increased, p62, LC3II content decreased, virus titer decreased, cell
survival rate increased, and damage rate decreased. Conclusion
EV71 can affect autophagy and promote self-replication by regulating
p53. Isochlorogenic acid B up-regulates p53 to promote autophagy,
inhibits EV71 replication in RD cells, and weakens its cytotoxicity,
which has a good anti-EV71 effect.
Oxycodone attenuates lipopolysaccharide-induced myocardial injury by inhibiting inflammation, oxidation and pyroptosis via Nrf2/HO-1 signaling pathway
Authors: Yu Wenli , Wang Yanting , Feng Wei , Li Shaona , Liu Cuicui , Jia Lili , Wang Pei , Li Linlin , Du Hongyin
Published: April 2024

Myocardial injury and cardiovascular dysfunction are the most common
complications in patients with sepsis, and effective therapeutic
candidate is still lacking. This study aims to investigate the
protective effect of oxycodone in the myocardial injury in
lipopolysaccharide-induced sepsis and its related signaling pathways.
Wildtype and Nrf2-knockout mice, as well as H9c2 cardiomyocytes culture
treated with LPS were used as models of septic myocardial injury. In
vitro model showed that oxycodone protected the cells from pyroptosis
induced by LPS. In vivo model showed oxycodone pretreatment
significantly attenuated myocardial pathological damage and improved
cardiac function with increased ejection fraction (EF) and fractional
shortening (FS) as well as decreased cardiac troponin I (cTnI), creatine
kinase isoenzymes MB (CK-MB). Oxycodone also reduced the levels of
inflammatory factors and oxidative stress damage induced by LPS, which
involves pyroptosis-related proteins including the NLRP3, Caspase-1,
ASC, and GSDMD. These changes were mediated by Nrf2 and HO-1 because
Nrf2-knockout mice or Nrf2 knockdown in H9c2 cells significantly
reversed the beneficial effect of oxycodone on oxidative stress,
inflammatory responses and NLRP3-mediated pyroptosis. Our findings
proved that oxycodone therapy reduces LPS -induced myocardial injury by
suppressing NLRP3-mediated pyroptosis via the Nrf2/HO-1 signaling
pathway in vivo and in vitro.
Wip1 inhibitor CCT007093 alleviates immune exhaustion of lymphocytes via p65 NF-κB and YY1 in chronic hepatitis B virus infection in mice
Authors: You Yu-Syuan , Chang Wan-Ting , Hsu Chia-Lang , Lu Yan-Fong , Wang Hui-Ying , Kim InKyeom , Tzeng Shiang-Jong
Published: April 2024

Background and Purpose: Prolonged viral infections often lead to
lymphocyte exhaustion, marked by heightened inhibitory receptor
expression like PD-1, compromising host defense mechanisms. Although
monoclonal antibodies like anti-PD-1 can alleviate exhausted
lymphocytes, their cost limits widespread use. The unexplored potential
of chemical checkpoint inhibitors in rejuvenating immune responses
prompted our investigation. Experimental Approach: We focused on
CCT007093, a Wip1 inhibitor, screened out for its unique ability to
concurrently reduce PD-1 and FcγRIIB expression, using a murine model of
immune exhaustion induced by chronic hepatitis B virus (HBV) infection.
Key Results: CCT007093 treatment to HBV-infected mice resulted in
decreased levels of PD-1 expression, resulting in reduced percentages of
PD-1+/hi CD4 and CD8 T cells in circulation, spleen, and liver. PD-1 and
FcγRIIB expression, alongside the percentages of PD-1+/hi and
FcγRIIB+/hi CD19+ B cells in these tissues, were similarly diminished.
Moreover, CCT007093-treated intrahepatic lymphocytes exhibited
heightened responsiveness to ex vivo activation. Together, serum HBsAg
levels were significantly reduced in in treated mice compared to
controls. Detailed analysis uncovered p65 NF-κB as the primary activator
of T cells and B cells, while YY1 emerged as the key regulator,
orchestrating the down-regulation of PD-1 and FcγRIIB gene transcription
in response to CCT007093. Conclusions and Implications: Our study
highlights CCT007093’s pharmacological efficacy in mitigating immune
exhaustion in HBV-infected mice, selectively enhancing adaptive
immunity. Beyond antiviral applications, it underscores the prowess of
chemical checkpoint inhibitors, exemplified by CCT007093, in alleviating
immune exhaustion induced by viruses and potentially in various cancers.
Growth processes in subtropical Eucalyptus plantations alter the soil bacterial community composition and soil multifunctionality
Authors: Ye Shaoming , Fan Rongyuan , He Yaqin , Lan Yahui , Zhang Han , Jiang Chenyang , Cui Yuhong
Published: April 2024

Short-rotation forestry is a common practice worldwide for efficient
timber harvesting. However, determining the appropriate rotation period
to minimize disturbance to plantation-soil ecosystems remains a
controversial topic. The microbial community structure is a sensitive
indicator of soil quality in plantation forests. Therefore, we analyzed
the soil bacterial community composition, co-occurrence network,
functional characteristics and influencing factors in subtropical
Eucalyptus plantation forests of different ages and revealed the
mechanisms through which soil ecosystem function is affected. Soil
carbon (C), nitrogen ( N) and phosphorus (P) decreased and then
increased with forest age, and there was temporal variability in the
composition and function of the soil bacterial communities; the
bacterial community composition and diversity and function of young and
overmature forest stands contributed most. Changes in total nitrogen
(TN), dissolved organic nitrogen (DON), total phosphorus (TP), and
available phosphorus (AP) supported the bacterial community pattern,
which was dominated by Acidobacteria and Proteobacteria. The
distributions of Acidobacteria and Proteobacteria were stable during the
growth phase of the Eucalyptus plantation. The low-abundance
bacterial communities WPS-2, Actinobacteria, Firmicutes, and
Bacteroidetes contributed to the main functions of the bacterial
communities, among which WPS-2 and Actinobacteria dominated the soil C
fixation and N cycle functions. This study evaluated the response
of bacterial communities to soil environmental factors during plantation
forest development and elucidated the microbial controls on soil
multifunctionality, which is important for improving ecosystem
simulation models in subtropical Eucalyptus plantation forests
and planning sustainable management during rotational logging periods.
High-precision measurement of 36 SF 5 + signal using the MAT 253 Ultra isotope-ratio mass spectrometer
Authors: Sun Xiang , Tong Fengtai , Peng Yongbo , Bao Huiming
Published: April 2024

Rationale: The Δ S standard deviation (SD)
measured in a conventional isotope-ratio mass spectrometer (IRMS) such
as MAT 253 is at c.a. 0.1‰ to 0.3‰. At this precision, it is
difficult to resolve the origin of non-mass-dependent sulfur (NMD-S)
isotope fractionation in the tropospheric sulfate aerosol and in Martian
meteorites or small deviations from the canonical mass-dependent
fractionation laws. Interfering ions (originated from fluorination
and/or mass spectrometer ion source itself) with m/z at 131 of
SF by the
community as the cause of the poor precision, but the exact ion species
has not been identified or confirmed. Methods: Here we examined
the potential interfering ions by using the Thermo Scientific MAT 253
Ultra, a high-resolution (mass resolving powers up to 40,000) stable
isotope-ratio mass spectrometer, to measure the SF
working gas and SF gases converted from IAEA-S1 Ag
S reference materials via a fluorination system.
Results: We found that there is a resolvable peak to the right
of the SF peak
for both the SF working gas and SF
generated by the fluorination system. The peak is identified as the
C F ion, generated inside the instrument during the
ionization process. By minimizing the presence of carbon-bearing
compounds (e.g., organic matter in sample or helium gas, glue or o-ring
in sample tubes, or carbon-bearing gases inside the mass spectrometer),
we were able to achieve a Δ S SD of 0.046‰ (n=8) for
SF zero-enrichment and 0.069‰ (n=8) for overall
measurement start from sliver sulfide IAEA-S1. Conclusions:
Minimizing the presence of carbon-bearing compounds and avoiding the
interfering signals from SF via MAT 253 Ultra high‐resolution isotope-ratio mass
spectrometer, we can improve Δ S measurement
precision by 2 to 5 folds, which helps to open new territories for
research using quadruple sulfur isotope composition.
Online toolkits for collaborative and inclusive global research in urban evolutionary ecology
Authors: Savage Amy , Willmott Meredith , Moreno Pablo , Li Daijiang , Malesis Anna , Jagiełło Zuzanna , Miles Lindsay , Kuzyo Hanna , Palacios Cristian Román , Salazar David , Verrelli Brian , Winchell Kristin , Alberti Marina , Carlen Elizabeth , Falvey Cleo , Johnson Lauren , Martin Ella , Marzluff John , Munshi-South Jason , Phifer-Rixey Megan , Stadnicki Ignacy , Szulkin Marta , Bonilla-Bedoya Santago , Zhou Yuyu , Gotanda Kiyoko
Published: April 2024

Urban evolutionary ecology is inherently interdisciplinary. Moreover, it
is a field with global significance. However, bringing researchers and
resources together across fields and countries is challenging.
Therefore, an online collaborative research hub, where common methods
and best practices are shared among scientists from diverse geographic,
ethnic, and career backgrounds would make research focused on urban
evolutionary ecology more inclusive. Here, we describe a freely
available online research hub for toolkits that facilitate global
research in urban evolutionary ecology. We provide rationales and
descriptions of toolkits for: (1) decolonizing urban evolutionary
ecology; (2) identifying and fostering international collaborative
partnerships; (3) common methods and freely-available datasets for trait
mapping across cities; (4) common methods and freely-available datasets
for cross-city evolutionary ecology experiments; and (5) best practices
and freely available resources for public outreach and communication of
research findings in urban evolutionary ecology. We outline how the
toolkits can be accessed, archived, and modified over time in order to
sustain long-term global research that will advance our understanding of
urban evolutionary ecology.
Allosteric Modulation of Fluorescence Revealed by Hydrogen Bond Dynamics in a Genetically Encoded Maltose Biosensor
Authors: Atilgan Canan , Berksoz Melike
Published: April 2024

Genetically encoded fluorescent biosensors (GEFBs) proved to be reliable
tracers for many metabolites and cellular processes. In the simplest
case, a fluorescent protein (FP) is genetically fused to a sensing
protein which undergoes a conformational change upon ligand binding.
This drives a rearrangement in the chromophore environment and changes
the spectral properties of the FP. Structural determinants of successful
biosensors are revealed only in hindsight when the crystal structures of
both ligand-bound and ligand-free forms are available. This makes the
development of new biosensors for desired analytes a long
trial-and-error process. In the current study, we conducted µs-long all
atom molecular dynamics (MD) simulations of a maltose biosensor in both
the apo (dark) and holo (bright) forms. We performed
detailed hydrogen bond occupancy analyses to shed light on the mechanism
of ligand induced conformational change in the sensor protein and its
allosteric effect on the chromophore environment. We find that two
strong indicators for distinguishing bright and dark states of
biosensors are due to substantial changes in hydrogen bond dynamics in
the system and solvent accessibility of the chromophore.
Harnessing cold adaptation for post-glacial colonisation: galactinol synthase expression and raffinose accumulation in a polyploid and its progenitors
Authors: Griffiths Andrew G. , Fechete Lavinia Ioana , Larking Anna , Heslop Angus , Hannaford Rina , Anderson Craig , Hong Won , Prakash Sushma , Mace Wade , Alikhani Salome , Hofmann Rainer , Tausen Marni , Schierup Mikkel Heide , Andersen Stig Uggerhøj
Published: April 2024

Allotetraploid white clover formed during the last glaciation through
hybridisation of two European diploid progenitors from restricted
niches: one coastal, the other alpine. Here, we examine which
hybridisation-derived molecular events may have underpinned white
clover’s post-glacial niche expansion. We compared the transcriptomic
frost responses of white clovers (inbred line and an alpine-adapted
ecotype), extant descendants of its progenitor species and a
resynthesised white clover neopolyploid to identify genes that were
exclusively frost-induced in the alpine progenitor and its derived
subgenomes. From these analyses we identified galactinol synthase, the
rate-limiting enzyme in biosynthesis of the cryoprotectant raffinose,
and found that the extant descendants of the alpine progenitor as well
as the neopolyploid white clover rapidly accumulated significantly more
galactinol and raffinose than the coastal progenitor under cold stress.
The frost-induced galactinol synthase expression and rapid raffinose
accumulation derived from the alpine progenitor likely provided an
advantage during early post-glacial colonisation for white clover
compared to its coastal progenitor.
Orbital (Hydro)Climate Variability in the Ice-Free early Eocene Arctic
Authors: Fokkema Chris Daniël , Brinkhuis Henk , Peterse Francien , Sluijs Appy
Published: April 2024

We explore the imprint of orbital variability on Arctic temperature and
hydrology using sediments recovered during the Arctic Coring Expedition
in 2004. High resolution records of lipid biomarkers (GDGTs; 2-kyr) and
palynological assemblages (5-kyr) in the ~4 m interval
below Eocene Thermal Maximum 2 (~54 Ma) show highly
cyclic signals related to ~20-kyr precession,
~40-kyr obliquity and ~100-kyr
eccentricity. The GDGTs indicate obliquity and precession variability
representative of sea surface temperature (SST) variations up to
~1.4 and ~0.5 ºC, respectively. Peak
SSTs coincide with an elevated supply of pollen and spores and increased
marine productivity. Together, this implies an orbital control on
precipitation and terrestrial nutrient supply to the Arctic Basin.
Assuming that SST maxima correspond to Arctic insolation maxima
(precession minima/obliquity maxima), precipitation maxima also
correspond to insolation maxima, implying regional hydrological
processes as a forcing rather than variations in meridional water
transport, starkly contrasting Pleistocene Arctic hydrology. The
relative amplitudes of precession and obliquity in the SST record match
that of local insolation between spring and fall, corroborating previous
suggestions of a seasonal GDGT bias. The reconstructed complete orbital
imprint refutes that ACEX temperature reconstructions are biased to one
end of the orbital variability. Eccentricity-related SST variability was
~0.8 ºC, ~2–3 times higher than
synchronous variability in the deep ocean, and 3–4 times higher than
similar variations in the tropics. This confirms eccentricity-forced
global temperature variability during the Eocene, and that this had
pronounced polar amplification, despite the absence of ice and snow
albedo feedbacks.
Hábitos saludables en estudiantes del nivel primario en Perú: revisión descriptiva literal
Authors: Pastor Rodríguez Eliot
Published: April 2024

Algunos informes de EsSalud (2020) indicaron que ciertos hábitos ligados a la salud impactaron negativamente en los niños de 6 a 12 años de edad durante el periodo del covid-19. Por eso, esta investigación tuvo como objetivo indagar sobre el estado de la cuestión y la promoción de hábitos saludables en los colegios de educación primaria en el Perú. Al no encontrarse antecedentes, esta indagación se centró en artículos publicados entre los años 2018 y 2022 sobre los hábitos saludables en los escolares de 6 a 12 años del nivel primario en el Perú. En cuanto a la metodología, la investigación fue descriptiva, con enfoque cualitativo. En concreto, se hizo una revisión bibliográfica en sitios web y bases de datos como Sciencie, Scielo, Scopus del Perú y Renati, para lo cual se usaron ecuaciones de búsqueda con palabras claves y operadores lógicos. En cuanto a los resultados, se seleccionaron 54 artículos: 8 de actividad física, 32 de alimentación saludable, 10 de hábitos de higiene saludable y 4 sobre la calidad del sueño. Finalmente, la investigación descubrió que los escolares presentan deficiencias en sus hábitos alimenticios, higiénicos, de esparcimiento y físicos debido a múltiples factores, como falsas creencias, malas prácticas, carencia de servicios básicos, agua potable, artículos de aseo personal, dentífricos, jabones y abuso de alimentos procesados. Los datos recogen propuestas válidas para mejorar los hábitos saludables de los escolares, los cuales van desde promover el ejercicio físico y ofrecer dietas saludables hasta monitorear la regulación de productos y propagandas alimenticias.
SOME POTENTIAL REQUIREMENTS FOR THE FORMATION OF THE GUT MICROBIOTA IN PRETERM INFANTS: PART 1
Authors: Znamenska T. , Vorobiova O.
Published: April 2024

Abnormal microbial colonization of the gut from birth in newborns aff ects growth, development, and health, leading to short- and long-term adverse eff ects. The microbiota of preterm infants diff ers from that of term ones. This is because preterm infants and their mothers have more complicated prenatal and postnatal health conditions and anatomically- functional immaturity of organs and systems depending on gestational age. Maternal conditions, antibiotics, type of feeding, and use of probiotics can signifi cantly aff ect the gut microbiota of preterm infants in the early neonatal period; however, these eff ects decrease with age. Although some factors and processes are diffi cult to intervene or avoid, understanding the potential factors and determinants will help to develop timely strategies to promote a healthy gut microbiota in preterm infants. This review discusses potential determinants of gut microbial colonization in preterm infants,the underlying mechanisms, and recommendations for addressing adverse eff ects.
EFFECTS OF UMBILICAL CORD MILKING ON HEMATOLOGICAL PARAMETERS IN TERM NEONATES: A CASE CONTROL STUDY IN A TERTIARY CARE HOSPITAL
Authors: Sankannavar Ashwini , Masali Balavanthray , Prakash Kulkarni Poornima
Published: April 2024

Delayed cord clamping (DCC) and Umbilical cord milking (UCM) are the two methods of placental transfusion. Bothinterventions improve hemoglobin, are safe with no risk of polycythemia and hyperbilirubinemia. UCM is benefi cial in situation were DCC is not feasible or contraindicated.Objectives. 1) Comparison of UCM and DCC on following hematological parameters in term neonates- Cord Hemoglobinat birth, Hemoglobin, Hematocrit and Bilirubin at 48 hours of life. 2) To compare Hb and ferritin levels of infants born withUCM to that of DCC at 6 weeks of age.Material and methods. A Prospective Case- Control Study. Newborns delivered by normal vaginal and elective lower segmentcesarean section underwent DCC. Neonates in whom DCC was not feasible underwent UCM. 56 neonates in each group were followed up to 6 weeks. Cord hemoglobin at birth, hemoglobin, hematocrit and bilirubin were sent at 48 hours, and during 6 weeks of life, Hb and serum ferritin was estimated in both groups and compared.Results: At 48 hours, mean hemoglobin is 18.75 and 19.38 g/dL, mean hematocrit is 52.20 and 53.94 %, and mean totalbilirubin is 11.56 and 10.39 mg/dL in the DCC and UCM groups, respectively. Mean hemoglobin at 6 weeks is 11.37 and 11.6 gm/dL and mean serum ferritin is 207.2 and 252.63 mcg/L in the DCC and UCM groups, respectively. No increase in the incidence of neonatal jaundice or polycythemia was observed in either group.Conclusion. Both the methods of placental transfusions DCC and UCM are equally eff ective and have comparable benefi ton hematological parameters in full term neonates at 48 hours of life and at 6 weeks of life.
MEDICAL CARE OF NEWBORNS WITH MECONIUM ILEUS. DATA ANALYSIS OF WORLD EXPERIENCE AND OWN OBSERVATIONS
Authors: Gorbatyuk O. , Martyniuk T.
Published: April 2024

According to various scientists, 10-20 percent of newborns with cystic fi brosis have meconium ileus (MI).MI is an obstruction of the small intestine that occurs in fetuses during the 20th-24th week of gestation due to a violation of the processes of the formation of meconium. The latter has an increased viscosity and cannot pass through the intestines causing their obturation. About 50 percent of the cases of MI are complicated by intestinal volvulus, intestinal atresia, malrotation, perforation with the development of meconium peritonitis and ascites, the formation of a meconium pseudocyst etc. The goal of the research is to conduct a systematic overview of the literature on the issue of MI in neonatal patients and to off er optimal tactics of medical support of newborns with MI on the basis of the analysis of relevant literary sources and our own observations related to this topic.The results. The overview of the literature in the historical aspect covering the last 20 years has demonstrated the following: due to the development and improvement of the methods of conservative surgical treatment of newborns with MI the mortality of the newborns with MI has decreased. The analysis of the data based on the global experience as well as on our own observations indicates the possibility of conservative therapy and surgical treatment of infants with MI and testifi es to the fact that in 50 percent of cases of uncomplicated MI the conservative treatment can be an eff ective option.The research contains the description of the step-by-step measures of conservative treatment. The indications for surgical interventions have also been specifi ed in the research.Conclusion. In treatment of newborns with MI resections and stomata should be avoided. Instead, preference should be given to gastric lavage.
A DEEP DIVE INTO GRADUATE STUDENTS’ SELF-EFFICACY AND ACADEMIC INTERACTION IN ONLINE LEARNING
Authors: Anas Ismail , Nur Sahril , Afdaliah Afdaliah , Irmawati Irmawati , Akhmad Akhmad
Published: April 2024

Research into self-efficacy has received widespread recognition in the literature. However, little study has been done on students’ self-efficacy in asynchronous online academic interactions. This study examined graduate students’ self-efficacy in regulating their online interaction strategies. Grounded in the Asynchronous Online Self-Regulated Learning Inventory (AOSRLI), the study employed a virtual case study using an online self-assessment survey and focus group interview. Seventy-eight English education master students from two universities were approached and agreed to participate in the study. As a result, the study highlighted several critical findings: 1) lack of confidence in online interaction with the professors, 2) closed-mindedness to criticism, 3) self-fanaticism, and 4) the need for self-dialoguing and self-navigation. The students were commonly inactive, indifferent, and demotivated in their asynchronous online interactions, thus creating ineffective learning communication among them. Self-regulated learning cannot grow alone and rely on the students’ in-person learning initiatives, whereas they need pedagogical imperatives to scaffold their questioning, responding, and critiquing skills. The study suggests improving teachers’ scaffolding strategies and building students’ online community of practice to promote their activeness, engagement, and participation. The implication of this study calls for the inclusion of asynchronous virtual interaction skills into online learning pedagogy and CALL teacher education.
ATTENTION TO PROBLEMATIC SOCIAL GROUP REPRESENTATION IN GUIDANCE FOR USING MASS MEDIA IN ENGLISH EDUCATION
Authors: Brown Charles Allen
Published: April 2024

While media studies amply document problematic social group representation in mass media materials, how English language educators are equipped to address these issues when they engage in the common practice of appropriating such artifacts for teaching is unclear. This research responds by collecting 319 prominent Internet sources providing guidance on using mass media materials for language learning and subjecting them to a content analysis. This analysis draws upon ten forms of problematic social group portrayal in the mass media as a conceptual lens. Analysis results indicate little attention to ableism, ageism, Christonormativity, classism, colorism, gender bias, heternormativity, lookism/sizeism, racism, and urbanormativity with articles universally acclaiming the integration of mass media materials into language teaching, primarily on the grounds of “authenticity.” Defined as materials authored by and for native speakers, this is an authenticity insensitive to authentic social group representation. This research is significant because of teacher reliance on the Internet as a source of materials, because of the global reach of English language teaching, the power of mass media, especially for youth socialization, and because there is a lack of previous research concerning how language teachers are trained to consider problematic social group representation in mass media artifacts.
Фотоны. Периодический процесс вместо волнового
Authors: Чеснаков Михаил
Published: April 2024

В статье показано, что применение модели гипотетического Фотона, не обладающего волновыми свойствами, тем не менее, объясняет причину когерентности Фотонов за щелью, отвечает на вопрос о механизме возникновения дифракционных максимумов и указывает на связь интерференционных явлений с квантовыми эффектами. В статье утверждается, что дифракция – это не волновой процесс, а периодический процесс сложения положительных амплитуд. Кроме того, дается объяснение поведению Фотона в пространстве, уточняются принципы относительности движения и особенности энергетического взаимодействия при движении частиц.

The paper shows that the application of the model of a hypothetical Photon, which does not possess wave properties, nevertheless, explains the reason for the coherence of Photons behind the slit, answers the question about the mechanism of the appearance of diffraction maxima, and indicates the connection between interference phenomena and quantum effects. The paper argues that diffraction is not a wave process, but a periodic process of addition of positive amplitudes. In addition, an explanation is given for the behavior of the Photon in space, the principles of relativity of motion and the features of energy interaction during the movement of particles are clarified.
Environmental information provision in the mechanism of environmental and information policy of Ukraine
Authors: Danyliuk L. R.
Published: April 2024

The article analyzes the concepts of information society, environmental information provision, information policy, environmental policy, establishes the importance of environmental information provision in implementing environmental and information safety measures, determines the place and role of environmental information provision in the mechanism of environmental and information policy of Ukraine.

The development of a high-quality information society is impossible without appropriate legal regulators and should not happen by itself, without state support. At the same time, the formation of a conscious information society is the key to the functioning of a democratic state and its institutions. Also, the developed institute of environmental information provision is the basis of not only environmental, but also informational, and therefore national security.

In the conditions of growing environmental problems and challenges, which have significantly worsened as a result of the war, it is important to understand the value for citizens of the right to environmental information, its role in guaranteeing environmental safety in the country and the potential of its provision for the further development of the state in any spheres.

Environmental information provision is a category that can be used not only in environmental, but also in informational and other legal relations. Moreover, the peculiarities of its legal regime are determined by the norms of constitutional, international, informational, administrative, civil law and are regulated in detail by environmental legislation.

However, despite the fact that the regulation of environmental and informational relations is carried out by the norms of various branches of law and is one of the basic foundations of both environmental and informational policy of Ukraine, it is necessary to distinguish their essence and substantive meaning in the context of certain measures.

The article concludes that within the framework of environmental policy, environmental information provision is an element of the legal mechanism (tool) for the implementation of this policy. Whereas within the framework of information policy, it is a type of information, access to which is guaranteed by the state, that is, rather, the object to which such a policy is directed.
Cooperation of The National Police of Ukraine with civil society on the basis of partnership under the conditions of the state of martial
Authors: Bondar V. V.
Published: April 2024

The article examines the prospects for the interaction of the National Police of Ukraine with the population on the basis of partnership under martial law and analyzes the recently implemented projects, the purpose of which is the effective implementation of the tasks assigned by the state, primarily related to the protection of the highest values of the state, which include man and his rights and freedom. It is emphasized that the introduction of martial law in Ukraine requires not only the solution of tasks related to the introduction and implementation of measures of the legal regime of martial law, since in the course of repelling armed aggression against Ukraine, police bodies participate in the performance of territorial defense tasks, carry out increased patrolling, escort appropriate cargoes, protection of property of victims, protection of destruction sites, delivery of offenders, restriction of traffic on dangerous routes, conducting exercises with representatives of the population, etc. The main problems that arise during the interaction of the National Police with the population at the current stage under the conditions of the legal regime of martial law in Ukraine are highlighted, the ways to solve them are outlined, it is proposed to develop a normative legal act on the organization of the interaction of the police with the population, in which the goal should be fixed interactions, tasks, define individual concepts, define subjects and heads of interaction bodies, types and forms of interaction, features of mutual information, channels of information transmission, methods and deadlines for checking the effectiveness of interaction, determine principles, as well as directions of interaction in the conditions of the legal regime of military state in Ukraine.

It is concluded that the legal regulation of the interaction of the National Police bodies with the population under the conditions of the legal regime of martial law in Ukraine should be understood as the system of legal means (elements), the totality of techniques and methods of legal influence on social relations that arise during such interaction, with the help of which a complex of organizational and special measures aimed at protection against illegal encroachments, as well as ensuring the personal safety of citizens, countering offenses is defined.
Characteristic of mutual Agreement procedure in case of the double taxation treaty between Azerbaijan and Ukraine
Authors: Hasanov Parviz Arif
Published: April 2024

The article is dedicated to comparative and legal analysis of the provisions on mutual agreement procedure in Art. 25 of the Convention between the Government of Ukraine and the Government of Azerbaijan Republic on Avoidance of Double taxation and Prevention of Tax Evasion regarding Taxes on Income and Capital dated 30 July 1999 in the context of recommendations included in Art. 25 of the OECD Model Tax Convention. The latter one is widely recognized source of interpretation of norms of bilateral double taxation treaties in many countries including Ukraine. This analysis, on the one hand, is aimed at finding ways of improvement of normative basis of mutual agreement procedure taking into consideration the risk of high number of tax disputes (for example, the replacement of the term ‘person’ with the term ‘resident’ in the first sentence of Art. 25(1) of the abovementioned Convention creates the risk of ambiguity in the context of personal scope of mutual agreement procedure in case of non-compliance of contracting state with the duties on non-discrimination regime) and, on the other hand, is assisting in the determination of compliance of Art. 25 of the abovementioned Convention with other international commitments of both contracting states (e.g., both contracting states have accepted commitments to introduce three-year minimum term for initiation of mutual agreement procedure by taxpayers according to the framework of the global campaign on counteracting base erosion and profit shifting but Art. 25(1) of the mentioned Convention does not mention such limitation in contrast to the provisions of Art. 25(1) of the OECD Model Tax Convention). Moreover, the author also admits that Art. 25(2) of the bilateral Convention does not include reference to the duty on implementation of mutual agreements concluded between competent authorities under the mutual agreement procedure without the link to the domestic time limits that is also not in accordance of the multilateral commitments. On the basis of this analysis, the author determines the need of amendments of Art. 25(1) and Art. 25(2) of the mentioned Convention that could improve efficiency and effectiveness of mutual agreement procedure as a mechanism of dispute resolution.
Characteristics of legislation in the field of health protection
Authors: Gegliuk O. M.
Published: April 2024

The article examines the essence of administrative and legal regulation in the field of health care through the prism of the systematization of administrative legislation in the specified field. The legal regulation of public administration is defined as a purposeful activity of state authorities regulated by laws and other normative acts, which is aimed at consolidating, organizing and protecting social relations in the specified sphere, which is carried out with the aim of preserving and strengthening health, protecting the rights of patients and medical employees. Attention is focused on determining the role and importance of such types of systematization as incorporation, consolidation, codification, adaptation and their application in the field of health care.

It was determined that the codification of administrative legislation in the field of health care is the most advanced form of systematization, which is directly related to the change in the form and content of the current legislation by its revision, elimination of conflicts, gaps, obsolescence and multiplicity of legal norms. Special attention is paid to adaptation, as a fundamental component of the European integration course of Ukraine, which consists in the phased adoption and implementation of laws and subordinate normative legal acts of Ukraine, developed considering the European Union legislation, as well as in making appropriate changes to the current legal acts of Ukraine.

Analysis was conducted and the reasons that complicate the classification of legislation in the field of health care were determined, with the complexity of legal regulation being the main one. The classification of health care legislation according to the principle of hierarchy, subject and scope of legal regulation, as well as by the number of persons is proposed.

The necessity of supplementing the current Code of Administrative Offences with the section “Offences in the Sphere of Health Care” is substantiated, which will establish responsibility for administrative offences in the sphere of health care, as well as strengthen administrative responsibility for their commission. The specified changes will ensure regulation of relations in the field of medical services, protection of the rights of doctors and patients, and as a result will improve the quality of medical assistance to the population.
State market surveillance of non-food products in Ukraine: analysis of the decision of the Constitutional Court of Ukraine № 9-r(ii)/2023 dated November 1, 2023 in case № 3-53/2022(126/22)
Authors: Dyrdin M. E. , Yatsyk T. P.
Published: April 2024

The article analyzes the problem of state market supervision of non-food products in Ukraine. Problematic aspects of administrative and economic responsibility for putting into circulation products that do not meet the established requirements are considered. The decision of the Constitutional Court of Ukraine No 9-р(ii)/2023 of November 1, 2023 in case No 3-53/2022(126/22) and the separate opinion of the judge of the Constitutional Court of Ukraine G.V. Yurovskaya were analyzed on this issue. It is noted that strengthening consumer protection and improving quality control and safety of products and services are important tasks for any country, including Ukraine. And the creation of an effective legislative mechanism that guarantees consumer rights and determines the responsibility of enterprises for the quality and safety of products stimulates the development of entrepreneurship and competitiveness in the market, which in turn helps to improve the investment climate and ensures a balanced development of the economy. The process of improving legislation on the protection of consumer rights is considered. It has been proven that legislative changes in this area were aimed at reducing corruption risks in the field of monitoring compliance with requirements for the quality and safety of products and services, and the increase in fines for product distributors who did not provide the necessary documentation for supplier identification was aimed at creating economic conditions at which it will be unprofitable to trade products without proper documents. Attention has been drawn to the possibility of establishing absolutely defined and (or) non-alternative sanctions in acts of public legislation in the case when the subject of law enforcement is a government body other than a court. A balance between clarity of sanctions and flexibility in their application has been proven to help ensure fairness and efficiency of the legal system.
Matters related to key features of the by-law contestation administrative proceedings
Authors: Yefimenko N. V.
Published: April 2024

The article points out that in cases concerning appeals against normative acts in the presence of obvious signs of its unlawfulness and violation of the rights or legitimate interests of a person who has filed a lawsuit against such an act, this lawsuit can be accompanied by an interim remedy stopping the effect of the respective normative act. This is allowed in exceptional cases when, on the basis of the evidence available in the case, the court is convinced that the contested act clearly contradicts the criteria of its lawfulness established by law on administrative proceedings. At the same time, one cannot claim that an exceptional case for stopping the effect of a normative legal act, when the norms of substantive law establish an alternative procedure for the exercise of rights affected by the contested normative legal act (in particular, if it is possible to act on the basis of normative acts having higher legal force). In addition, when deciding the issue of suspending the effect of a normative legal act, the court must observe the limits of judicial intervention in the activities of their issuers and respect their discretionary powers, primarily those that lie in the domain of their exclusive executive functions, especially those that are characterized by political and narrowly-specialized character.

The author, moreover, maintains that in order to encourage plaintiffs to use their right to claim and procedural rights in good faith, it is proposed to establish the date when the plaintiff learned or should have learned about the violation of his rights and legitimate interests. It is also clarified that termination of a person’s participation in social relations, the participants of which are assigned rights and duties by the relevant normative act, as well as the termination of the normative legal act itself, is the starting point for calculating the timeframe for its appeal to court.

The article also indicates that there are critical gaps in the legislative provisions, which give rise to uncertainty regarding the impact of the published announcement on the appeal of a normative act on timeframes of appeal to the administrative court for other addressees of the relevant normative legal act, as well as regarding the procedural status of those who expressed their intention to join before consideration of the case on its unlawfulness.
The Dualistic Nature of the Competence of Civil-Military Administrations: On the Formulation of the Problem
Authors: Zhuravel T. S.
Published: April 2024

The article highlights the controversial issues of executive branch dualism in Ukraine and highlights the problems of the dualistic nature of the competence of civil-military administrations. It is noted that since the proclamation of Ukraine’s independence and up to now, political and legal discussions have been taking place around the problems of executive power organization. It is emphasized that the origins of the problem of executive dualism should be sought from the formation of the system of public authorities in Ukraine in the 90s of the twentieth century. During this period, there was a rather complicated political struggle and a search for the most optimal model of building a system of state authorities, which certainly affected the construction of the executive branch, and gave rise to a number of problems related to the dualism of power. The author emphasizes that the problems of dualism in the sphere of higher authorities have caused the same problems in the system of executive authorities and their relations with other types of public authorities, in particular, with local self-government bodies. The author analyzes and summarizes the problems in the field of relations between local public authorities (local executive authorities and local self-government bodies) and identifies the following: conceptual problems of delimitation of powers between certain executive authorities and local self-government bodies, legal problems of delimitation of powers between certain executive authorities and local self-government bodies; institutional problems. It is emphasized that dualism was also observed in the course of functioning of civil-military administrations, although in this case it was of a slightly different nature, which is due to the special legal status of the latter. The author identifies the peculiarities of such dualism. The author emphasizes the need to improve the legal framework for the functioning of civil-military administrations, to carry out institutional changes (search for a model, structure, etc.), to organize work, to apply new forms and methods of management, and to conduct further scientific research.
Administrative responsibility for violation of customs rules during the movement of goods by natural persons across the customs border of Ukraine: reasons and signs
Authors: Nima A. O.
Published: April 2024

The article is devoted to the disclosure of the features of administrative responsibility in the movement of goods by natural persons across the customs border of Ukraine, its grounds and features. Attention is focused on the categories: «offence», «customs offence», «natural person», «resident», «non-resident»,   «customs   rules»,   «administrative   responsibility»,   «violation   of   customs   rules», «administrative responsibility for violation of customs rules». It was found that the violation of customs rules during the movement of goods by individuals across the customs border of Ukraine belongs to the category of administrative offenses and is a type of legal responsibility. It is suggested that the violation of customs rules in the case of movement of goods by individuals across the customs border of Ukraine should be understood as intentional or negligent action or inaction of an individual who interferes with the established procedure for movement of goods by them across the customs border of Ukraine, implementation of customs clearance procedures and customs control of such goods, or ( or) exemption or settlement of customs payments. It has been proven that the elements of violation of customs rules when moving goods by individuals across the customs border of Ukraine must include: a) object; b) the objective side; c) subject; d) the subjective side.

The grounds for administrative liability for violation of customs rules during the movement of goods by natural persons across the customs border of Ukraine have been disclosed. A proper definition of administrative responsibility for violation of customs rules during the movement of goods by individuals across the customs border of Ukraine is proposed as a specific form of negative response of the state in the form of its authorized bodies (customs and judicial) to violations of customs rules during the movement of goods by individuals across the customs border, according to which physical persons who have committed such violations are subject to onerous consequences of a material or other nature for their illegal actions and provides for administrative fines for this in the order and form determined by the Customs Code of Ukraine. The signs of administrative responsibility for violation of customs rules during the movement of goods by individuals across the customs border of Ukraine have been clarified.