bluuebunny/crossref_metadata_2025 huggingface dataset:
Mediation Effect of Social Connectedness between Death Anxiety and Ego Integrity among Elderly
Authors:   Crisis and Emergency Management: Theory and Praxis, Kim Yunyoung
Published: January 2025

This study aims to understand the impact of death anxiety on ego integrity among the elderly and to examine the mediating effect of social connectedness on the relationship between anxiety and ego integrity. Data were collected from residents aged 60 and above living in City A and County Y from September to November 2023. Out of the collected data, 290 responses were analyzed using the SPSS 28.0 Statistics Program and multiple regression analysis. The results revealed that death anxiety had a negative correlation with both ego integrity and social connectedness, while ego integrity had a positive correlation with social connectedness. Furthermore, social connectedness was found to partially mediate the relationship between anxiety and ego integrity, with the model explaining 31% of the variance. The study concludes that to help the elderly move beyond death anxiety, accept death as a part of life, and correctly form ego integrity a developmental task in old age improvements in social connectedness are necessary, along with the development of various supportive programs.
render
Authors: Nikolau Katherine
Published: January 2025

render, a publication created by Writing and Rhetoric graduate Katherine Nikolau, celebrates the creative work and activism of nine justice-impacted artists, considering how different acts of composing can be healing for people who have experienced incarceration. The nine featured artists create artwork that spans across genres, including poetry, spoken word, visual art, music, theater, and fabric art. At the same time, these artists are also working on the frontlines of criminal justice reform, getting involved with various advocacy organizations and working to heal others in their communities. Through profile pieces chronicling multiple-hour-long interviews conducted with each of these artists, render aims to challenge the stigmas surrounding returning citizens and to instead celebrate this diverse group of creatives and the transformative work they do every day.
Clinical Outcomes in a Multicenter Cohort Involving 919 Patients With Hypertriglyceridemia-Associated Acute Pancreatitis
Authors: Deng Hanzhang , Peng Kaixin , Zhang Liang , Lu Jiongdi , Mei Wentong , Shi Xiaolei , Peng Yunpeng , Xu Kedong , Li Haoxuan , Wang Zheng , Lu Guotao , Wang Gang , Lu Zipeng , Cao Feng , Wen Li ,   for the Chinese Hypertriglyceridemia-associated Pancreatitis Study Group (CHPSG)
Published: January 2025

INTRODUCTION:

Hypertriglyceridemia-associated acute pancreatitis (HTG-AP) is one of the most common etiologies of acute pancreatitis (AP) worldwide. Compared with other etiologies, patients with HTG-AP may develop more severe AP, but previous studies yielded controversial conclusion due to the lack of adequate adjustment for the confounders. Therefore, the aim of this study was to examine the possibility and risk factors of developing severe AP in HTG-AP.

METHODS:

Data from patients with an established diagnosis of AP were collected from January 2013 to December 2023 using a predesigned data collection form and were gathered from 5 tertiary cross-regional centers of China. HTG-AP was defined as serum triglyceride levels >500 mg/dL and excluded other etiologies. The possibility and risk factors of severe AP were assessed by multivariable logistic regressions after adjusting potential confounders. A prediction model was established and validated.

RESULTS:

Between 2013 and 2023, we identified a total of 6,996 patients with AP, of whom 4,378 were included in the final analysis. Compared with other etiologies, patients with HTG-AP had a higher risk of developing severe AP (odds ratio: 1.897; 95% confidence interval: 1.380–2.608; P < 0.001) and organ failure. HTG-AP patients showed higher possibility for developing respiratory and circulation failure but renal failure compared with other etiologies. In HTG-AP patients, risk factors of severe AP included age, fasting blood glucose, white blood cell counts, and presence of pleural effusion. TG level was found not significantly associated with severity in HTG-AP patients. A prediction model incorporating these risk factors demonstrated an area under the curve (AUC) of 0.837 in the training and 0.883 in the testing set, with adequate calibration.

DISCUSSION:

Using a multicenter cross-regional cohort, we demonstrated that HTG-AP had a higher risk of developing severe AP and organ failure. A risk prediction model for predicting severe AP was developed and effectively stratified patients.
Quantitative Change of Hepatitis B Surface Antigen Leading to Final Hepatitis B Surface Antigen Loss in Patients with Chronic Hepatitis B Receiving Nucleos(t)ide Analogs in China
Authors: Zhou Tianhui , Shu Meng , Luo Fangyun , Dong Sijia , Teng Jiaming , Du Yanan , Qiu Hong , Cai Wei
Published: January 2025

INTRODUCTION:

Loss of hepatitis B surface antigen (HBsAg) is the pivotal component of functional cure in patients suffering from chronic hepatitis B (CHB). The predictive value of quantitative HBsAg (qHBsAg) in HBsAg loss among those undergoing nucleos(t)ide analog (NAs) therapy is an area of ongoing investigation.

METHODS:

A retrospective cohort study using electronic medical records was performed. CHB patients with NAs treatment between January 1, 2012, and December 31, 2020 were enrolled and followed up until discontinuation of NAs, as indicated by a gap more than 12 months in prescription refills, past medical record, or study end. Patients were grouped into NAs treatment-naïve cohort and treatment-experienced cohort. In both cohorts, Cox regression models assessed associations between 12-month reduction in qHBsAg, baseline qHBsAg, and HBsAg loss.

RESULTS:

Overall, 2,627 CHB patients with NAs treatment was identified, including 1,179 in treatment-naïve cohort and 1,448 in treatment-experienced cohort. In treatment-naïve cohort, 9 patients had HBsAg loss (0.51/100 person-years). In treatment-experienced cohort, 30 patients had HBsAg loss (1.03/100 person-years). HBsAg loss was significantly associated with a 0.5–1 log10 (treatment-naïve: adjusted hazard ratio [aHR] 8.06, 95% confidence interval [CI] 1.29–50.40; treatment-experienced: aHR 4.34, 95% CI 1.40–13.47) and >1 log10 qHBsAg decrease (treatment-naïve: aHR 9.19, 95% CI 1.47–57.65; treatment-experienced: aHR 8.02, 95% CI 1.76–36.57) compared with qHBsAg not reduced. HBsAg loss was significantly associated with lower baseline qHBsAg in treatment-experienced cohort, while such difference was not significant in treatment-naïve cohort.

DISCUSSION:

A rapid decline of qHBsAg in 12 months during NAs therapy, as opposed to merely maintaining a low level of qHBsAg, was associated with HBsAg loss.
Perintah Mengajar dalam Perspektif Tafsir Tarbawi: Telaah Nilai Pendidikan Islam dari Al-Qur'an
Authors: Rahmawati Lady Eka , Putra Sudarmadi
Published: January 2025

This article aims to examine the interpretation of Qur'anic verses related to the basis of the teaching command for all mankind. Teaching obligations are included in the realm of educational studies. The interpretation of verses of the Qur'an related to the field of education is called the term tafsir tarbawi. Formulate the problems including a) what are the teaching vocabulary in the Qur'an, b) how the ulama interpret the verses about teaching, c) the implementation of the educational value of the verses. This research uses a qualitative method and is described in a descriptive manner (content analysis) in the form of library research. The results of the study concluded that the terms teaching in the Qur'an include 'allama (???????), rabbani (??????) and balligh (????). The verses of the obligation to teach are listed in Surah al-Baqarah verse 33 and Surah al-Maidah verse 67. The value of the implementation of education from these two verses makes people realize that teaching is not solely a professional realm but is actually a divine command, as Allah SWT., commanded the Prophet Adam (as), and the Prophet Muhammad (PBUH) to teach.
Determinasi Religiusitas, Lokasi, dan Faktor Sosial dalam Pemilihan Program Studi Bahasa Arab di STIM Surakarta
Authors: Romadhon Farkhan Nur , Putra Sudarmadi , Budiriyanto Anis , Winanto Edy , Widodo Joko
Published: January 2025

This study aims to analyze the influence of religiosity, location, and social factors on students' choices in choosing the Arabic Language Study Program at STIM Surakarta. The approach used is qualitative with a case study method. Data were collected through in-depth interviews, observations, and documentation. Data analysis was carried out using a thematic approach to understand the influence of the three factors. The results of the study show that student religiosity is the main driver in choosing this study program, supported by the strategic location of the campus and social factors such as family and community support. This study provides insight for study program managers to design strategies to increase attractiveness based on these factors. On the other hand, the religiosity factor has a smaller influence than the other two factors.
Implementasi Metode Tadhadh (Antonim) dalam Pemerolehan Kosakata Bahasa Arab Melalui Hiwar Berbahasa Arab
Authors: Widodo Joko , Putra Sudarmadi , Budiriyanto Anis , Winanto Edy , Romadhon Farkhan Nur
Published: January 2025

This study aims to describe the implementation of the Tadhad (antonym) method in acquiring Arabic vocabulary and analyze students' understanding of vocabulary acquired through the Tadhad method in Arabic language learning for 10th-grade students of Class A at SMA ISLAM 1 Surakarta. The study employs a qualitative approach using observation, interviews, and document analysis to obtain in-depth data related to students' learning experiences and vocabulary acquisition progress through the antonym method. The findings indicate that the application of the Tadhad method in Arabic vocabulary learning is effective in enhancing students' understanding of new word meanings due to the logical associations between antonyms, improving vocabulary comprehension through semantic relationships and real-world contexts, and helping students gain confidence in speaking Arabic. However, the implementation of this method requires additional strategies, such as the use of contextual examples and repeated practice, to maximize learning outcomes.
Implementasi Pendidikan Karakter pada Mata Pelajaran Bahasa Arab di Madrasah Ibtidaiyah
Authors: Triani Triani , Putra Sudarmadi , Riyadi Slamet
Published: January 2025

This study aims to investigate the implementation of character education in Arabic language learning at MIM Al-Qomariyah Klego. Character education focuses on strengthening moral and ethical values relevant to daily life. In the context of religious education, character development is an integral part of learning, including Arabic language instruction, which teaches Islamic values. This qualitative case study employs observation, interviews, and documentation to explore character education implementation. The results show that character education integration, active-participatory learning methods, and supportive media characterize Arabic language learning at MIM Al-Qomariyah Klego. Supporting factors include teacher commitment and conducive classroom management, while challenges include limited resources and time constraints. This study informs strategies to enhance character education quality in madrasahs.
A patient choice‐driven lifestyle intervention lowers HbA1c in type 2 diabetes: A feasibility study
Authors: Weeldreyer Nathan R. , McEntee Mindy L. , Martin Matthew P. , Lee Chong D. , Marvasti Farshad Fani , Gaesser Glenn A. , Kessler Rodger , Angadi Siddhartha S.
Published: January 2025

Type 2 diabetes (T2D) is a common metabolic disorder in which only 25% of patients meet management targets. While the primary care setting is positioned to provide lifestyle management education, studies are lacking which integrate behavior interventions in this setting utilizing clinic staff. Thus, we evaluated a 90‐day lifestyle intervention for management of glycemia at a family practice clinic administered by clinic medical assistants. Twenty patients with non‐insulin‐dependent T2D completed a 90‐day intervention driven by patient choices of nutrition and physical activity. Medical assistants were trained by members of the study team and administered the intervention under nurse practitioner supervision. HbA1c trended toward significant reduction 8.59 ± 0.9% to 8.15 ± 1.2% (p = 0.051, 95% CI: −0.88 to 0.003). Modest reductions were observed for waist circumference (115.5 ± 12.6 vs. 112.5 ± 15.2 cm; p = 0.014, 95% CI: −5.66 to −0.26), body weight (97.7 ± 21.9 vs. 95.6 ± 23.9 kg; p = 0.016. 95% CI: −3.84 to −0.31), and BMI (33.7 ± 7.2 vs. 32.8 ± 7.5 kg/m2; p = 0.028, 95% CI: −1.29 to −0.12). This 90‐day, patient choice‐intervention was successful at lowering HbA1c in patients with T2D. Our study is limited by a lack of control group, and results should be interpreted as such. These data have implications for team‐based care models in clinic settings to improve health outcomes in patients with T2D.
Implementation of data transmission mechanism in a Bi-directional optical fiber network
Authors: Gummadi Dinesh Venkat , Karanam Harish Naidu , Samudrala Sivanaga Akshaya , Nampally Harshavardhan , Prasanna Preethi Priya Darshini Sagabala , Sindhwani Manoj , Sachdeva Shippu , Shukla Manoj Kumar
Published: January 2025

Passive optical network (PON) has become the leader in delivering broadband high-speed connectivity. The paper introduces a detailed description of PON, its working principle, key features, and their potential applications. In addition, we discuss the types of PON architectures including GPON, EPON, and XG-PON with merits and demerits. Finally, we discuss the technical considerations of PONs in data transmission mechanisms, network design, and component selection. This paper further demonstrates the use of PON technology via a case study on the design and implementation of a bidirectional optical fiber network. Within this project, we went ahead to demonstrate the use of PON components including optical splitters, transmitters, receivers, and power controllers towards the development of an efficient and functional network structure. It mainly covered the results of the project since the PONs appeared to be a promising solution for obtaining high-performing and reliable broadband services.
The case of romantic relationships: analysis of the use of metaphorical frames with ‘traditional family’ and related terms in political Telegram posts in three countries and three languages
Authors: Höhn Sviatlana
Published: January 2025

Language technology – starting from the handwriting in early ages of humanity and perfectionated in the age of social media and micro-targeting - is used to gain and maintain power, and to rebel against it. Social media such as Telegram provide a safe space for freedom fighters in authoritarian regimes but also offer a stage for extremist, aggressive and manipulative content. This work uses romantic relationships as an example topic. The article discusses how the language used shapes the interpretation of political reports based on literature. Further, this work analyses metaphorical frames around the concepts related to romantic relationships and family in influential news outlets from three countries in three languages. The analysis shows that conservative political actors use similar metaphorical frames for relationship-related concepts such as LGBT and ‘traditional family’, and with similar, manipulative purposes. The results suggest that anti-democratic discourses build on exploitation of social categories rendered subordinate to men in a similar way across conservative movements. However, changes in political leadership can facilitate societal changes towards more open and more democratic societies, but they can also change cultures and traditions to suit power interests.
OLGA: Innovative Local Wisdom-Based Marine Ecology Learning Media for Fifth-Grade Students
Authors: Laily Yulia Nisfiatul , Ramadhani Amalia Ulfa , Dimyati Maftuh Fauji , Wijayanti Arfilia
Published: January 2025

This study introduces OLGA (Ocean Lomban Game), an innovative learning media integrating local wisdom to enhance marine ecology education for fifth-grade elementary students. Given the serious threats to global marine resources from human activities and climate change, early aquatic ecology and conservation education is crucial. OLGA incorporates the traditional Lomban Kupatan ritual from Tayu, Pati, emphasizing ecological balance and cultural heritage. Using the ADDIE model (Analysis, Design, Development, Implementation, Evaluation), the research involved evaluating current curriculum needs, designing a storyboard, developing the game with MIT App Inventor and animation videos, and implementing it in a classroom setting. Pre-tests and post-tests were conducted to measure effectiveness. The results indicated that OLGA significantly improved students' interest and performance in learning marine ecology. Validation by experts confirmed the media's suitability and effectiveness. Teacher and student feedback highlighted its practicality and ease of use, making OLGA a promising educational tool. The study concludes that OLGA effectively combines science education with local cultural elements to foster ecological awareness among students.
Chronic pelvic pain treatment understanding what matters: a social media survey
Authors: Johnson Selina , Evans Emma , Hapangama Dharani K
Published: January 2025

Chronic pelvic pain (CPP) is a debilitating condition that reduces quality of life (QoL). In the United Kingdom, there is currently no standardised treatment pathway for women suffering from CPP. Therefore, it is essential to understand individuals’ concerns regarding CPP, their treatment experiences and what they seek from treatment. To do this, we conducted a two-month social media survey focused on the UK population to explore treatment experiences and identify the factors that people consider important to managing their condition. Of 1,279 respondents, women who completed ≥50% of the questions were included (n = 864; 68%). Results suggest that many women are living with moderate-intensity CPP and experience symptoms for 6 years (average) before receiving a diagnosis. Initially, most women see general practitioners and gynaecologists (90%), with varied care beyond these providers. Using an adapted STarT Back tool, 85% of respondents were classified as medium–high risk of poor outcomes based on physical, psychosocial, and psychological risk. Thematic analysis identified that people desire treatment validation/understanding, self-management, and support to manage pain and QoL. Notably, only 26% of respondents report satisfaction with their healthcare experience, suggesting that current treatment approaches do not address these themes. In conclusion, results suggest that treatment should focus on quality-of-life improvement to enhance CPP treatment outcomes and satisfaction. Findings endorse the need for improved and standardised treatment approaches that address patients’ needs.

Lay summary

CPP is persistent pain in the lower abdomen or pelvis for at least 6 months. It is common and affects approximately 1 in 6 women in the UK. To improve treatment, it is important to understand people’s treatment experiences and treatment needs. We conducted a social media survey to understand how people with CPP experience treatment and what they would like from treatment. The survey was posted online for two months (May and June 2023) and received 897 responses. Responses suggested that people experience long waits before receiving help for their pain and that treatment journeys vary greatly. Overall, people reported low treatment satisfaction. People felt that effective treatment should improve pain and QoL. Themes of understanding their pain, knowing how to manage their pain and understanding treatments were identified as important. Clinicians should consider QoL and pain education as part of treatment.
Experiences of Gender-Diverse Youth Living With Chronic Pain
Authors: Boerner Katelynn E. , Fox Danya A. , Du Levi , Metzger Daniel L. , Marshall Sheila , Moore Eva M. , Narang Pam , Wharton Marie-Noelle , Oberlander Tim F.
Published: January 2025

BACKGROUND

Although sex differences in pain are well documented, little is known regarding the relationship between gender and pain. Gender-diverse youth experience unique pain risk factors, including minority stress exposure, but are underrepresented in research.

OBJECTIVE

Elicit experiences of gender-diverse youth who live with chronic pain.

METHODS

Semistructured interviews were conducted with youth virtually using Zoom. Youth were recruited from a Canadian tertiary care pediatric hospital, community-based clinics, and the general population. Interviews were recorded, transcribed, and analyzed with a patient partner using reflexive thematic analysis, integrating relevant existing theoretical and empirical models for understanding gender and pain, identity development, minority stress, and intersectionality.

RESULTS

The final sample included 19 youth who represented a variety of gender identities and pain conditions and reported accessing a range of types and levels of care. Three themes were identified through qualitative analysis: (1) the fight to legitimize both their pain and gender, (2) the tension between affirming gender and managing pain and the role of gender euphoria as a buffer against pain, and (3) the role of intersecting (eg, neurodiversity and race) identities in understanding gender-diverse youths’ pain experiences.

CONCLUSIONS

In a diverse sample of gender-diverse youth who live with chronic pain, experiences of invalidation and difficulty managing pain were experienced in the context of unique stressors and sources of joy in living as a gender-diverse individual. These results point to the need for more intersectional and affirming pain research and integration of findings into clinical practice.
Predictors and Outcomes of Extubation Failure in Preterm Neonates: A Systematic Review
Authors: Hoff Calegari Lisiane , Goyal Medha , Dutta Sourabh , Mukerji Amit
Published: January 2025

CONTEXT

Extubation failure (EF) is common in preterm neonates and may be associated with adverse outcomes.

OBJECTIVE

To systematically review and meta-analyze the existing literature on predictors and outcomes of EF in preterm neonates.

DATA SOURCES

MEDLINE, Epub Ahead of Print, In-Process & Other Non-Indexed Citations, Embase (OvidSP), CINAHL (EBSCOHost), and Cochrane Library (Wiley) from 1995 onward. The search strategy was developed by a reference librarian.

STUDY SELECTION

Experimental or observational studies reporting on predictors and/or outcomes related to EF (defined as reintubation within 7 days) in preterm neonates less than 37 weeks were eligible. Predictors included machine learning (ML) algorithms and lung ultrasound (LUS). Main outcome of interest was association of EF with mortality and/or bronchopulmonary dysplasia (BPD).

DATA EXTRACTION

Studies identified by the search strategy were screened based on title and abstract. Data from included studies were extracted independently by 2 authors, along with adjudication of risk of bias. RevMan Web was used to conduct meta-analyses.

RESULTS

Out of 8336 studies screened, 120 were included. Neonates with lower gestational age at birth, birthweight, postmenstrual age, and weight at extubation were more likely to experience EF. Higher level of pre-extubation respiratory support, indicated by lower pre-extubation pH and higher pre-extubation mean airway pressure, fraction of inspired oxygen, and Pco2 were associated with EF risk. ML models showed variable accuracy and lower external validity. LUS may be a promising predictor, though scoring systems varied. EF was associated with higher odds of mortality and/or BPD (pooled odds ratio [OR], 4.7; 95% CI, 2.84–7.76) as well as the individual components of the composite: mortality (pooled OR, 3.87; 95% CI, 2.35–6.36) and BPD (pooled OR, 3.27; 95% CI, 2.54–4.21).

LIMITATIONS

Associations were derived from unadjusted data, precluding a definitive causal relationship between EF and predictors/outcomes.

CONCLUSIONS

Lower gestational and chronological age and higher levels of pre-extubation ventilation support were associated with EF. ML models and LUS scores require further validation in larger studies. EF was associated with mortality and/or BPD.
Isotopías recurrentes en el discurso de los Pah y Mah
Authors: Espinosa-Patrón Alejandro
Published: January 2025

La investigación tuvo como objetivo general identificar las Isotopías recurrentes en el discurso de los Pah y Mah, y cómo desde su posición de enunciadores, que abrevian o acortan las palabras para estar en su mundo de la “moda” o de la ligereza, pueden crear una estructura innovadora para comunicarse entre ellos. Además, se empleó el método semiocrítico para estudiar el corpus que los soporta como “sujetos consumidores” de su realidad signíca.
Study on the Status of Trademark Infringement and Countermeasures in Cross-Border E-Commerce in China
Authors:   Korea Association for International Commerce and Information, Liu Xue-Ping , Hong Seon-Eui
Published: January 2025

The rapid development of cross-border e-commerce has led to a significant increase in intellectual property rights (IPR) infringements and disputes. In particular, trademark infringement in China's cross-border e-commerce sector has become a critical issue. This study analyzes the current state and case studies of trademark infringement in China and derives the following key implications: (1) improving and internationalizing the legal framework for IPR in cross-border e-commerce, (2) enhancing the trademark protection awareness and capabilities of cross-border e-commerce enterprises, and (3) strengthening the role of cross-border e-commerce platforms in protecting intellectual property rights. Furthermore, practical and actionable countermeasures are proposed for each implication. These measures aim to establish an institutional framework to prevent trademark infringement in e-commerce at an early stage and provide a strategic direction for the role of cross-border e-commerce platforms in IPR protection.
The Impact of Central Government Research Funding on Regional Export Performance
Authors:   Korea Association for International Commerce and Information, Kim Dong Hyun
Published: January 2025

This study conducted an empirical analysis of the impact of central government research funding on regional export competitiveness in South Korea, focusing on 16 regions from 2009 to 2022. The evaluation of the time-lag effects of research funding and future export performance revealed that while the short-term impact was minimal, significant positive effects were observed in the medium to long term. Specifically, research funding was found to contribute positively to export volumes 1 to 3 years later, highlighting its role as a critical investment for enhancing future export competitiveness. The study demonstrates that the level of government research funding has a significant impact on improving export performance, underscoring its importance as a key policy tool for regional economic growth and export promotion. Furthermore, this study emphasizes the need for tailored policies to enhance the efficiency of research funding allocation and to promote balanced regional development.
Brain Aging: Key Theories and Neurophysiological Insights
Authors: Tretyakova V.D. , Pultsina K.I.
Published: January 2025

In recent years, the problem of brain aging is becoming more and more relevant due to the increasing proportion of elderly people in the population. One of the key issues in this area is the study of the effect of aging on cognitive functions and brain activity, since these functions play an important role in everyday life and determine a person’s ability to lead a full, independent life and adapt to a changing environment. The aim of this article was to review foreign literature concerning the main theories of cognitive aging such as the frontal cortex aging theory, compensatory theories, reserve theory, sensory deprivation theory, information processing speed reduction theory and inhibitory influence deficit theory. Particular attention is paid to the neurophysiological aspects of aging. The literature search was carried out by keywords using the Google Scholar and PubMed databases. The reviewed results of neurocognitive studies allow us to identify structural and functional changes in the brain during aging, which can help clinical specialists differentiate “normal” aging from possible signs of brain diseases and develop a more individual approach if necessary to correct cognitive impairment.
Age-related features of alpha rhythm dynamics: a brief review
Authors: Polikanova I.S. , Mikheev I.N. , Leonov S.V. , Martynova O.V.
Published: January 2025

In this mini-review, the age-related features of alpha rhythm dynamics, its generation sources, and its connection to cognitive functions are discussed. The review focuses on a brief systematization of data regarding the alpha rhythm of human brain bioelectrical activity and its informativeness in determining the biological age of the human brain. The alpha rhythm is characterized by high individual stability and exhibits pronounced age-related dynamics in its U-shape. The peak frequency of the alpha rhythm increases from infancy to young adulthood and then decreases during brain aging. Discussions about the sources of alpha rhythm generation are still ongoing. Current data show a lack of a clear connection between the peak frequency of alpha rhythm and human cognitive abilities and intelligence. Parameters of the alpha rhythm, such as individual stability, genetic predisposition, and age-related characteristics, make it a promising marker for both normative development and brain aging in determining cognitive and biological age.
Psychologist. Pedagogue. Person. On the Anniversary of Tatiana Germanovna Goryacheva
Authors: Sedova E.O.
Published: January 2025

Remarkable Russian neuropsychologist, the author of the sensory-motor correction method Tatiana Germanovna Goryacheva celebrates her anniversary in December of 2024. The article describes the milestones of her biography and marks out the main scientific interests, among them: psychology of abnormal development, neuropsychological correction, child psychosomatics. Many years of practical activity in the sphere of child neuropsychology have been mentioned and pedagogical talent of Tatiana Goryacheva has been emphasized. The staff of the Institute of Clinical Psychology and Social Work of the Pirogov RNRMU as well as the Department of Neuro- and Patho-psychology of Development at MSUPE cordially congratulates Tatiana Germanovna on her anniversary wishing her a good health and success in scientific and practical activity.
Early Rectal Cancer: Advances in Diagnosis and Management Strategies
Authors: Mohammed Huda Mohammed Abdalrahman , Mohamed Hadeel , Mohamed Nusyba , Sharma Rajat , Sagar Jayesh
Published: January 2025

Colorectal cancer (CRC) is the second most prevalent cause of cancer-related death and the third most common cancer globally. Early-stage rectal cancer is defined by lesions confined to the bowel wall, without extension beyond the submucosa in T1 or the muscularis propria in T2, with no indication of lymph node involvement or distant metastasis. The gold standard management of rectal cancer is total mesorectal excision (TME) however, it is linked to considerable risks, including genitourinary dysfunction, faecal incontinence, permanent stoma, and impaired quality of life. There is a rising interest in local resection and non-operative treatment of early RC for organ preservation. Local resection options include two types of transanal endoscopic surgery (TES); transanal endoscopic microsurgery (TEM), Transanal endoscopic operations (TEO) and transanal minimally invasive surgery (TAMIS), while the endoscopic resection includes endoscopic mucosal resection (EMR), underwater (UEMR) and endoscopic submucosal dissection (ESD).
Although the oncological outcome of local resection of early rectal cancer is debatable in the current literature, there are some studies that showed comparable outcomes with radical surgery in selected patients. Use of adjuvant and neoadjuvant chemoradiotherapy in early rectal cancer management is also controversial in the literature, but a number of studies showed promising outcomes.
This review focused on discussing variations in staging, diagnostic difficulties, management strategies, and outcomes with possible recommendations.
Multi-Model Approach for Stock Price Prediction and Trading Recommendations
Authors: Chen Zhenrui , Dai Zhibo , Xing Huiyan , Chen Junyu
Published: January 2025

The financial market has been at the forefront of machine learning applications since the 1980s, yet accurate stock price prediction remains a significant challenge due to market complexity and inherent volatility. This paper presents a comprehensive approach to stock market prediction through the integration of Linear Regression (LR), Long Short-Term Memory (LSTM), and Autoregressive Integrated Moving Average (ARIMA) methods. We evaluate these approaches using historical data from five major stocks across different market sectors, demonstrating that traditional time series analysis methods can achieve comparable or superior performance to complex deep learning approaches when properly optimized. To validate our findings, we implement an integrated prediction and trading support system that provides automated data processing and real-time updates, enabling effective decision-making in dynamic market conditions. Our results suggest that the combination of multiple prediction approaches, coupled with automated trading support, can significantly enhance investment decision-making capabilities.
Insight into The Life Cycle of Enterovirus-A71
Authors: Liu Qi , Long Jian-Er
Published: January 2025

Human enterovirus 71 (EV-A71), a member of the Picornaviridae family, is predominantly associated with hand, foot, and mouth disease in infants and young children. Additionally, EV-A71 can cause severe neurological complications, including aseptic meningitis, brainstem encephalitis, and fatalities. The molecular mechanisms underlying these symptoms are complex and involve the viral tissue tropism, evasion from the host immune responses, induction of the programmed cell death and cytokine storms. This review article delves into the EV-A71 life cycle, with a particular emphasis on recent advancements in understanding the virion structure, tissue tropism, and the interplay between the virus and host regulatory networks during replication. The comprehensive review is expected to contribute to our understanding of EV-A71 pathogenesis and inform the development of antiviral therapies and vaccines.
Body Composition Analysis in Metastatic Non-Small-Cell Lung Cancer: Depicting Sarcopenia in Portuguese Tertiary Care
Authors: Leão Mendes José , Ferreira Rita Quaresma , Mata Inês , Vasco Barreira João , Rodrigues Ysel Chiara , Silva Dias David , Capelas Manuel , Mäkitie Antti , Guerreiro Inês , Pimenta Nuno M , Ravasco Paula
Published: January 2025

Background/Objectives: Sarcopenia is an emergent prognostic biomarker in clinical oncology. Albeit increasingly defined through skeletal muscle index (SMI) thresholding, literature cut-offs fail to discern heterogeneous baseline muscularity across populations. This study assesses the prognostic impact of using cohort-specific SMI thresholds in a Portuguese metastatic non-small-cell lung cancer (mNSCLC) cohort. Methods: Retrospective study including mNSCLC patients treated between January 2017 and December 2022. ImageJ v1.54g was used to assess cross-sectional CT imaging at the third lumbar vertebra (L3) and calculate L3SMI. Sarcopenia was defined both according to Prado et al. and L3SMI thresholds derived from receiver operating characteristic analysis. Overall survival (OS) was the primary endpoint. Secondary endpoints included first-line (1L) progression-free survival (PFS) and sarcopenia subgroup analysis regarding body mass index impact on OS. Results: The initial cohort included 197 patients. Mean age was 65 years (± 11.31). Most tumors were adenocarcinomas (n = 165) and presented with metastasis (n = 154). SMI was evaluable in 184 patients: cohort-specific thresholds (< 49.96 cm2/m2 for men; < 34.02 cm2/m2 for women) yielded 46.74% sarcopenic patients (n = 86) versus 66.30% (n = 122) per the literature definition. Cohort-specific thresholds predicted both OS (12.75 versus 21.13 months, hazard ratio [HR] 1.654, p = 0.002) and PFS (7.92 versus 9.56 months, HR 1.503, p = 0.01). Conversely, Prado et al. definition lacked prognostic value. Among sarcopenic patients, overweight (HR 0.417, p = 0.01) and obesity (HR 2.723, p = 0.039) had contrasting impacts on OS. Conclusions: Amid reclassification of nearly one-fifth of the cohort, cohort-specific thresholds improved sarcopenia prognostication in mNSCLC. Homogeneity regarding both cancer treatment setting and ethnicity could be key to defining sarcopenia based on SMI.
Enhancing Brand Value Through Circular Economy Service Quality: The Mediating Roles of Customer Satisfaction, Brand Image, and Customer Loyalty
Authors: Sah Amit Kumar , Hong Yao-Ming , Huang Kuo-Chung
Published: January 2025

This study rigorously examines the relationship between circular economy service quality and brand value, focusing on the mediating roles of customer satisfaction, brand image, and customer loyalty. Amid growing adoption of circular economy principles to enhance sustainability and resource efficiency, the impact of such practices on brand value remains underexplored. This research addresses the gap by developing and testing an integrated model of circular economy service quality and its influence on brand value. Using a quantitative methodology, the study collected data from customers engaged with companies employing circular economy practices. A structured survey assessed perceptions of circular economy service quality, customer satisfaction, brand image, customer loyalty, and brand value. Advanced statistical techniques, including structural equation modeling (SEM), were employed to analyze the data and evaluate the proposed relationships. The results reveal significant positive correlations between circular economy service quality, customer satisfaction, brand image, and customer loyalty. Furthermore, the mediating roles of customer satisfaction, brand image, and customer loyalty in the relationship between circular economy service quality and brand value are validated. High-quality circular economy services foster customer satisfaction, enhance brand image, and strengthen customer loyalty, collectively driving increased brand value. This research underscores two critical implications. First, circular economy service quality is identified as a pivotal factor in enhancing brand value. By offering sustainable and efficient services, organizations can deliver superior customer experiences, cultivate a strong brand image, and ultimately boost brand value. Second, the mediating variables—customer satisfaction, brand image, and customer loyalty—are shown to play essential roles in amplifying the impact of circular economy service quality on brand value. Organizations should strategically focus on optimizing these factors to maximize brand performance. The findings provide valuable insights for businesses aiming to integrate sustainability into their operations while enhancing brand equity and market performance.
FE Modelling of Crack Width and Localization in Reinforced Concrete
Authors: Červenka Vladimir , Cervenka Jan , Rimkus Arvydas , Gribniak Viktor
Published: January 2025

The crack width assessment and reliable modelling of the crack localization process are essential for sustainability control in reinforced concrete structures affected by corrosion. Accurate modeling of crack propagation is critical for evaluating deflections, serviceability limit states, and the redistribution of internal forces, which influence ultimate limit states. This paper examines various modeling approaches and their impact on crack width predictions and load-displacement responses. The applied concrete cracking model uses the finite element method and nonlinear fracture mechanics. Influences of mesh size, reinforcement modeling approaches, and critical material parameters are analyzed. Results are validated against experimental data from direct tension tests of reinforced concrete prisms.
From Traditional Amazon Use to Food Applications: Tapirira guianensis Seed Extracts as a Triad of Antiproliferative Effect, Oxidative Defense, and Antimalarial Activity
Authors: Crispim Marcell , Silva Thaise Caputo , Lima Amanda dos Santos , Cruz Laura Da Silva , Bento Nathalia Alves , Cruz Thiago Mendanha , Stelle Yasmin , Mar Josiana Moreira , Rocha Daniel de Queiroz , Bezerra Jaqueline de Araújo , Azevedo Luciana
Published: January 2025

Tapirira guianensis is a tropical plant from South America widely used by indigenous communities due to its medicinal properties. The seeds are rich in phenolic compounds known for their anti-inflammatory, antioxidant, and antimicrobial properties. This study investigated the chemical composition, antioxidant potential, cytotoxic effects, and antimalarial properties of hydroethanolic, ethanolic, and aqueous seed extracts. The combination of water and ethanol (1:1) in the extraction proved to be efficient in obtaining bioactive compounds, resulting in the highest phenolic compound content and strong antioxidant activity. In addition, it reduced the viability of cancer cells, protected against damage caused by reactive oxygen species (ROS), decreased chromosomal aberrations, and proved to be highly effective against sensitive and resistant to chloroquine Plasmodium falciparum strains. These data indicate a promising profile of T. guianensis seed extracts in cytoprotective, antiproliferative, antioxidant, and antimalarial properties and point to the need for additional in vivo studies to better understand their mechanisms of action and safety.
Early Maturity Wheat as a Highly Valuable Feed Raw Material with Prebiotic Activity
Authors: Meskhi Besarion , Pakhomov Viktor , Rudoy Dmitry , Maltseva Tatyana , Olshevskaya Anastasiya , Mazanko Maria
Published: January 2025

The work is devoted to the study of the dynamics of changes in the composition of the heap of cereal crops during maturation and identifying the optimal stage at which the grain heap has a high feed value. The grain heap of winter wheat of the Admiral variety, perennial winter wheat (trititrigia) of the Pamyati Lyubimovoy variety and gray wheat grass of the Sova variety was studied for amino acid composition, protein content, moisture, iron, phosphorus, selenium, zinc, starch and Vitamin E. The heap of cereal crops harvested at the stage of hard wax ripeness has a higher protein content - by 3-4% on average, some amino acids, minerals (iron, selenium) and other useful nutrients. The grain heap of hard waxy ripeness wheat was studied for prebiotic properties. It was found that it causes an increase in the number of lactic acid bacteria in the intestinal microbiota and therefore is a promising prebiotic for agriculture. Based on the studies, the recommended concentration of grain heap of waxy ripeness wheat as a feed additive is 1%.
Multipoint Left Ventricular Pacing as Alternative Approach in Cases of Biventricular Pacing Failure
Authors: Antoniou Christos-Konstantinos , Chrysochoou Christina , Manolakou Panagiota , Tsiachris Dimitrios , Kordalis Athanasios , Tsioufis Konstantinos , Gatzoulis Konstantinos
Published: January 2025

Cardiac resynchronization therapy (CRT) is a cornerstone in the treatment of dyssynchronous heart failure with reduced ejection fraction. However, the phenomenon of non-response has plagued CRT since its initial application. Notwithstanding issues such as failure to capture the left ventricle, lower-than-required pacing delivery percent and failure to optimize atrioventricular and interventricular delays, there are patients who fail to exhibit adequate response to CRT in its classical biventricular pacing (BiVP) form. Several modalities have been proposed as a means to remedy this issue, including pacing the conduction system itself – His or left bundle branch pacing, allowing for intrinsic conduction in some myocardial segments, pacing the left ventricle from multiple points in the coronary sinus (multi-point pacing), or even combining the above (e.g. His/left bundle pacing and BiVP leading to His/left bundle-optimized CRT). In the present review we present recent evidence for the advantages and disadvantages of each modality and attempt to formulate a pathophysiology and simulation-based strategy to determine the best way forward for delivering CRT in non-responders to BiVP.
Health Care Stereotype Threat During the COVID-19 Pandemic Among Sexual and Gender Minority Individuals
Authors: Manning Wendy D. , Dush Claire Kamp , Gustafson Kristen
Published: January 2025

Objectives. To determine the levels and differentials in health care stereotype threat experienced during the COVID-19 pandemic by individuals with sexual or gender minority identities.

Methods. The National Couples’ Health and Time Use Study is a national cross-sectional US population‒ based sample of partnered individuals interviewed during the pandemic between September 2020 and April 2021 with oversamples of sexual and gender minority individuals. The analytic sample consisted of 3614 individuals (n = 2043 heterosexual and n = 1571 sexual minority individuals along with 3489 cisgender and 125 noncisgender people).

Results. Individuals with sexual minority identities experienced significantly more health care stereotype threat than heterosexual people. Cisgender women and those with another gender identity experienced significantly more health care stereotype threat than cisgender men. These results persisted after the inclusion of indicators of health conditions, insurance, COVID-19 experience, and sociodemographic factors.

Conclusions. Gender and sexual minority‒identifying people reported high levels of worries about health discrimination. Our work suggests that providing positive health care experiences may reduce these worries and offer a potential antidote to sexual and gender minority health disparities that are driven by structural and interpersonal discrimination. These findings support calls for the further education and transformation of health care provision and systems. ( Am J Public Health. 2025;115(3):425–433. https://doi.org/10.2105/AJPH.2024.307926 )
Floating the Flap: Suspension of Soft Tissue Free Flap Over External Fixation–Guided Bone Transport
Authors: Aysola Varun , Prince Daniel E. , Healey John H. , Singer Samuel , Mehrara Babak J.
Published: January 2025

Case:

Wide resection of a synovial sarcoma of the anteromedial distal leg involving the dimetaphyseal tibia and posterior tibial tendon produced an 8.5-cm osseous defect. To keep the free flap from invaginating into the defect and prevent kinking of the anastomosis, six 1.5-mm Ilizarov wires (held in place by the external fixator) were placed under the flap to suspend it over the defect. No problems resulted with the vascularity or healing of the flap or with consolidation of the defect.

Conclusion:

Suspending the flap over the defect with Ilizarov wires can prevent tissue invagination while avoiding need for additional procedures.