bluuebunny/crossref_metadata_2025 huggingface dataset:
Correction: Corrigendum: Structural basis of synaptic vesicle assembly promoted by α-synuclein
Authors: Fusco Giuliana , Pape Tillmann , Stephens Amberley D. , Mahou Pierre , Costa Ana Rita , Kaminski Clemens F. , Schierle Gabriele S. Kaminski , Vendruscolo Michele , Veglia Gianluigi , Dobson Christopher M. , De Simone Alfonso
Published: May 2017

Nature Communications 7: Article number: 12563 (2016); Published: 19 September 2016; Updated 11 May 2017 In the original version of Supplementary Data 1 associated with this Article, the FastPeakFind.m function was incorrectly attributed to the authors in the function’s header. This function is Copyright © 2012 Adi Natan, Stanford University (natan@stanford.
Cross-species gene modules emerge from a systems biology approach to osteoarthritis
Authors: Mueller Alan James , Canty-Laird Elizabeth G. , Clegg Peter D. , Tew Simon R.
Published: May 2017

Complexities in degenerative disorders, such as osteoarthritis, arise from multiscale biological, environmental, and temporal perturbations. Animal models serve to provide controlled representations of the natural history of degenerative disorders, but in themselves represent an additional layer of complexity. Comparing transcriptomic networks arising from gene co-expression data across species can facilitate an understanding of the preservation of functional gene modules and establish associations with disease phenotypes. This study demonstrates the preservation of osteoarthritis-associated gene modules, described by immune system and system development processes, across human and rat studies. Class prediction analysis establishes a minimal gene signature, including the expression of the Rho GDP dissociation inhibitor ARHGDIB, which consistently defined healthy human cartilage from osteoarthritic cartilage in an independent data set. The age of human clinical samples remains a strong confounder in defining the underlying gene regulatory mechanisms in osteoarthritis; however, defining preserved gene models across species may facilitate standardization of animal models of osteoarthritis to better represent human disease and control for ageing phenomena.
Placental O-GlcNAc-transferase expression and interactions with the glucocorticoid receptor are sex specific and regulated by maternal corticosterone exposure in mice
Authors: Pantaleon Marie , Steane Sarah E. , McMahon Kathryn , Cuffe James S. M. , Moritz Karen M.
Published: May 2017

Maternal stress programs offspring disease in a sexually dimorphic manner with males often more adversely affected. Previous studies of maternal glucocorticoid exposure suggest male vulnerability may derive from placental alterations. The hexosamine signalling pathway and O-linked glycosylation (O-GlcNAcylation) are part of an essential adaptive survival response in healthy cells. The key enzyme involved is O-linked-N-acetylglucosamine transferase (OGT), a gene recently identified as a sex-specific placental biomarker of maternal stress. Using a mouse model of maternal corticosterone (Cort) exposure, we examined components of hexosamine biosynthesis/signalling and O-GlcNAcylation in whole placentae at E14.5. Our results demonstrate sex-specific differences in OGT levels and O-GlcNAcylation during Cort exposure which impacts on key mediators of cell survival, in particular AKT as well as the stress responsive OGT/GR transrepression complex. In male placentae only, Cort exposure increased Akt O-GlcNacylation which correlated with decreased phosphorylation. Female placentae had higher basal OGT and OGT/GR complex compared with male placentae. Cort exposure did not alter these levels in female placentae but increased global O-GlcNacylation. In male placentae Cort increased OGT and OGT/GR complex with no change in global O-GlcNacylation. These findings suggest that sex-specific differences in placental OGT play a key role in the sexually dimorphic responses to stress.
Precise and diffraction-limited waveguide-to-free-space focusing gratings
Authors: Mehta Karan K. , Ram Rajeev J.
Published: May 2017

We present the design and characterization of waveguide grating devices that couple visible-wavelength light at λ = 674 nm from single-mode, high index-contrast dielectric waveguides to free-space beams forming micron-scale diffraction-limited spots a designed distance and angle from the grating. With a view to application in spatially-selective optical addressing, and in contrast to previous work on similar devices, deviations from the main Gaussian lobe up to 25 microns from the focus and down to the 5 × 10−6 level in relative intensity are characterized as well; we show that along one dimension the intensity of these weak sidelobes approaches the limit imposed by diffraction from the finite field extent in the grating region. Additionally, we characterize the polarization purity in the focal region, observing at the center of the focus a low impurity <3 × 10−4 in relative intensity. Our approach allows quick, intuitive design of devices with such performance, which may be applied in trapped-ion quantum information processing and generally in any systems requiring optical routing to or from objects 10 s–100 s of microns from a chip surface, but benefitting from the parallelism and density of planar-fabricated dielectric integrated optics.
Comparative genomic analysis reveals the environmental impacts on two Arcticibacter strains including sixteen Sphingobacteriaceae species
Authors: Shen Liang , Liu Yongqin , Xu Baiqing , Wang Ninglian , Zhao Huabiao , Liu Xiaobo , Liu Fei
Published: May 2017

How the genomic diversity of species is driven by geographical isolation and environmental factors are not well understood for cold environments. Here, the environmental stress responses of two phylogenetically close Arcticibacter strains, A. eurypsychrophilus MJ9-5 and A. svalbardensis MN12-7, isolated from a Tibetan Plateau glacier and Svalbard soil, were analyzed. The comparative genomic analysis was performed with sixteen other related Sphingobacteriaceae species. Analyses of the relationships between growth temperature and genome composition, cold and heat shock genes showed that genomic adaption characteristics were more obvious when the strains were grouped by their upper limit in growth temperature, rather than by their minimal or optimal growth temperatures for Sphingobacteriaceae species. The very divergent genetic distance of genome fractions assigned to the functions of ‘secondary metabolism’, ‘dormancy and sporulation’ and ‘metabolism of aromatic compounds’ indicated the heterogeneous evolution of genes under different environmental pressures of the Sphingobacteriaceae species. The greatest differences between strains MJ9-5 and MN12-7 occurred in the genes devoted to the CRISPRs, osmotic adaption and metabolism of monosaccharides, nitrogen and aromatic compounds. These distinctions corresponded to two different environmental pressures, salinity and nutritional level, in the glacier ice and Svalbard soil environments.
Multitrophic Effects of Belowground Parasitoid Learning
Authors: Willett Denis S. , Alborn Hans T. , Stelinski Lukasz L.
Published: May 2017

The ability to learn allows organisms to take advantage of dynamic and ephemeral opportunities in their environment. Here we show that learning in belowground entomopathogenic nematodes has cascading multitrophic effects on their hosts, other nematodes, and nematophagous fungal predators. In addition to quantifying these effects, we show that social behavioral plasticity in these belowground parasitoids can amplify signaling by plant defense pathways and results in an almost doubling of insect herbivore infection by entomopathogenic nematodes. Cumulatively, these effects point to the critical role of plant signaling in regulating community structure while suggesting an equally important role for behavioral plasticity in shaping community dynamics.
Comparative Proteomic Analysis of the Mitochondria-associated ER Membrane (MAM) in a Long-term Type 2 Diabetic Rodent Model
Authors: Ma Jacey Hongjie , Shen Shichen , Wang Joshua J. , He Zhanwen , Poon Amanda , Li Jun , Qu Jun , Zhang Sarah X.
Published: May 2017

The mitochondria-associated ER membrane (MAM) plays a critical role in cellular energetics and calcium homeostasis; however, how MAM is affected under diabetic condition remains elusive. This study presented a comprehensive proteome profiling of isolated brain MAM from long-term type 2 diabetic mice vs. non-diabetic controls. MAM protein was extracted efficiently by a surfactant-aided precipitation/on-pellet digestion (SOD) method, and MAM proteome was quantified by an ion-current-based MS1 method combined with nanoLC-MS/MS. A total of 1,313 non-redundant proteins of MAM were identified, among which 144 proteins were found significantly altered by diabetes. In-depth IPA analysis identified multiple disease-relevant signaling pathways associated with the MAM proteome changes in diabetes, most significantly the unfolded protein response (UPR), p53, hypoxia-related transcription factors, and methyl CpG binding protein 2. Using immunofluorescence labeling we confirmed the activation of three UPR branches and increased ERp29 and calreticulin in diabetic retinas. Moreover, we found GRP75, a key MAM tethering protein, was drastically reduced by long-term diabetes. In vitro, acute high glucose treatment reduces ER-mitochondrial contact in retinal endothelial cells. This study provides first insight into the significant alterations in MAM proteome associated with activation of the UPR in diabetes, which may serve as novel benchmarks for the future studies of diabetic complications.
Inhibition of corticotropin-releasing hormone receptor 1 and activation of receptor 2 protect against colonic injury and promote epithelium repair
Authors: Li Bo , Lee Carol , Filler Tali , Hock Alison , Wu Richard You , Li Qi , Chen Shigang , Koike Yuhki , Ip Wan , Chi Lijun , Zani-Ruttenstock Elke , Määttänen Pekka , Gonska Tanja , Delgado-Olguin Paul , Zani Augusto , Sherman Philip M. , Pierro Agostino
Published: May 2017

Maternal separation (MS) in neonates can lead to intestinal injury. MS in neonatal mice disrupts mucosal morphology, induces colonic inflammation and increases trans-cellular permeability. Several studies indicate that intestinal epithelial stem cells are capable of initiating gut repair in a variety of injury models but have not been reported in MS. The pathophysiology of MS-induced gut injury and subsequent repair remains unclear, but communication between the brain and gut contribute to MS-induced colonic injury. Corticotropin-releasing hormone (CRH) is one of the mediators involved in the brain–gut axis response to MS-induced damage. We investigated the roles of the CRH receptors, CRHR1 and CRHR2, in MS-induced intestinal injury and subsequent repair. To distinguish their specific roles in mucosal injury, we selectively blocked CRHR1 and CRHR2 with pharmacological antagonists. Our results show that in response to MS, CRHR1 mediates gut injury by promoting intestinal inflammation, increasing gut permeability, altering intestinal morphology, and modulating the intestinal microbiota. In contrast, CRHR2 activates intestinal stem cells and is important for gut repair. Thus, selectively blocking CRHR1 and promoting CRHR2 activity could prevent the development of intestinal injuries and enhance repair in the neonatal period when there is increased risk of intestinal injury such as necrotizing enterocolitis.
A versatile microfluidic device for high throughput production of microparticles and cell microencapsulation
Authors: Akbari Samin , Pirbodaghi Tohid , Kamm Roger D. , Hammond Paula T.
Published: May 2017

We introduce a robust microfluidic platform for production of relatively homogenous microdroplets at generation frequency of up to 3.1 MHz, about three orders of magnitude higher than the production rate of a conventional microfluidic dropmaker.
A simple synthetic entryway into palladium cross-coupling catalysis
Authors: Zinser Caroline M. , Nahra Fady , Brill Marcel , Meadows Rebecca E. , Cordes David B. , Slawin Alexandra M. Z. , Nolan Steven P. , Cazin Catherine S. J.
Published: May 2017

The simple synthesis of a family of palladates containing an imidazolium counterion is presented. These “ate” complexes can be easily converted into well-defined palladium–N-heterocyclic carbene (NHC) complexes.
A pulse electrosynthesized nanoporous nickel oxyhydroxide-borate thin film in electro- and photoelectro-reforming of methanol for selective production of formate
Authors: Lin Chia-Yu , Chueh Yu-Chien , Wu Cheng-Hsien
Published: May 2017

A highly efficient and robust nanoporous NiOOH-borate thin film for the selective production of formate via electrochemical and photoelectrochemical methanol reforming is reported.
A designer ligand field for blue-green luminescence of organoeuropium(ii) sandwich complexes with cyclononatetraenyl ligands
Authors: Kawasaki Kenshiro , Sugiyama Rion , Tsuji Takashi , Iwasa Takeshi , Tsunoyama Hironori , Mizuhata Yoshiyuki , Tokitoh Norihiro , Nakajima Atsushi
Published: May 2017

A designer ligand field is demonstrated for the blue-green photoluminescence of organoeuropium(ii) sandwich complexes.
A zwitterionic hydrocarbon-soluble borenium ion based on a β-diketiminate backbone
Authors: Abdalla Joseph A. B. , Tirfoin Rémi C. , Niu Haoyu , Aldridge Simon
Published: May 2017

A hydrocarbon-soluble borenium/borate zwitterion has been developed which is more strongly Lewis acidic than B(C6F5)3, despite featuring a pendant (non-fluorinated) aryl group and two flanking N-donors.
Packing arrangement of13C selectively labeled sequence model peptides of Samia cynthia ricini silk fibroin fibers studied by solid-state NMR
Authors: Asakura Tetsuo , Miyazawa Kenta , Tasei Yugo , Kametani Shunsuke , Nakazawa Yasumoto , Aoki Akihiro , Naito Akira
Published: May 2017

Samia cynthia ricinisilk fibroin fiber was proposed to take anti-parallel β-sheet structure with staggered arrangement.
Concentration dependent phase behavior and collapse dynamics of PNIPAM microgel by dielectric relaxation
Authors: Yang Man , Liu Chunyan , Zhao Kongshuang
Published: May 2017

Concentration dependent phase behavior of microgel: the dense system underwent a phase transition from colloidal crystal to liquid and to phase separation (above); the dilute system only underwent a transition from liquid to phase separation (below).
Regular and red-shifted fluorescence of the donor–acceptor compound 5-(1H-pyrrole-1-yl)thiophenecarbonitrile (TCN) is efficiently quenched by internal modes of thiophene
Authors: Bohnwagner Mercedes V. , Burghardt Irene , Dreuw Andreas
Published: May 2017

The photochemical properties of thiophene analogs ofN-pyrrolobenzonitrile (PBN), notably the two isomers 5-(1H-pyrrole-1-yl)thiophene-2-carbonitrile (2-TCN) and 5-(1H-pyrrole-1-yl)thiophene-3-carbonitrile (3-TCN) have been investigated.
Diacetylene polymerization on a bulk insulator surface
Authors: Richter A. , Haapasilta V. , Venturini C. , Bechstein R. , Gourdon A. , Foster A. S. , Kühnle A.
Published: May 2017

Atomic force microscopy images and density-functional theory calculations elucidate on-surface diacetylene polymerization on the bulk insulator surface of calcite.
Ultrasensitive and reproducible SERS platform of coupled Ag grating with multibranched Au nanoparticles
Authors: Kalachyova Yevgeniya , Mares David , Jerabek Vitezslav , Ulbrich Pavel , Lapcak Ladislav , Svorcik Vaclav , Lyutakov Oleksiy
Published: May 2017

The ultra high sensitive and reproducible surface enhanced Raman substrate has been made through the immobilization of sharp-edges specific gold nanoparticles on the silver grating surface.
Adsorption differences between low coverage enantiomers of alanine on the chiral Cu{421}R surface
Authors: Gladys Michael J. , Han Jeong Woo , Pedersen Therese S. , Tadich Anton , O’Donnell Kane M. , Thomsen Lars
Published: May 2017

The lower coverage has a stronger adsorption of alanine on the chiral Cu{421}R than the higher coverage.
Intrinsic ferromagnetism and quantum anomalous Hall effect in a CoBr2monolayer
Authors: Chen Peng , Zou Jin-Yu , Liu Bang-Gui
Published: May 2017

The electronic, magnetic, and topological properties of a CoBr2monolayer are studied in the framework of density-functional theory (DFT) combined with tight-binding (TB) modeling in terms of the Wannier basis.
Stability of radiation-damaged DNA after multiple strand breaks
Authors: Landuzzi Fabio , Palla Pier Luca , Cleri Fabrizio
Published: May 2017

Radiation induced double-strand breaks in DNA are more stable against thermal and mechanical stress than usually thought.
Comparison of halogen bonding networks with Ru(ii) complexes and analysis of the influence of the XB interactions on their reactivity
Authors: Mosquera Marta E. G. , Egido Irene , Hortelano Carlos , López-López María , Gómez-Sal Pilar
Published: May 2017

Coordination compounds of formula [Ru(Cl)2(CNR)4] are interesting building blocks for the preparation of halogen bonding supramolecular networks, since the chloride ligand is a good XB acceptor. When using I2 as the XB donor, an unexpected reaction on the ruthenium coordination sphere happens where the chloride ligands are substituted by iodides. The isolation of several intermediates with different substitution degrees and showing XB interactions in a solid state network evidenced the clear influence of the XB species in this unusual reaction process. The extension of the studies to bromine gave the analogous result, i.e. the substitution of the chloride ligands by bromides. Furthermore, changing the organic substituent in the isocyanide ligands from alkyl to aryl does not affect the outcome of the reaction; however the process is faster when the alkyl substituents are present. In the course of the study of these reactions we have isolated a whole range of XB-based networks were interactions such as Cl⋯I–I, Br⋯Br–Br, I⋯I–I and I⋯Br–Br are present, a systematic comparison of the XB structural features for the different networks isolated and the influence in their reactivity has been performed.
Aqueous phase reforming of glycerol using doped graphenes as metal-free catalysts
Authors: Esteve-Adell Iván , Crapart Bertrand , Primo Ana , Serp Philippe , Garcia Hermenegildo
Published: May 2017

Boron-doped graphene obtained by pyrolysis at 900 °C of the boric acid ester of alginate was found to be the most active graphene among a series of doped and co-doped graphenes to promote the aqueous phase reforming of glycerol at 250 °C.
One-pot integrated biofuel production using low-cost biocompatible protic ionic liquids
Authors: Sun Jian , Konda N. V. S. N. Murthy , Parthasarathi Ramakrishnan , Dutta Tanmoy , Valiev Marat , Xu Feng , Simmons Blake A. , Singh Seema
Published: May 2017

We present an inexpensive and biocompatible protic ionic liquid that enables one-pot integrated cellulosic ethanol production without any pH adjustments and without water-wash or solid–liquid separations.
Inducible Bcl-2 gene RNA interference mediated by aptamer-integrated HDV ribozyme switch
Authors: Zhang Yuanyuan , Wang Jine , Cheng Hui , Sun Na , Liu Min , Wu Zhengyan , Pei Renjun
Published: May 2017

We designed HDV ribozymes with an embedded theophylline aptamer and pri-miRNA of endogenous gene Bcl-2 to engineer an RNAi-regulatory device.
Finding a helix in a haystack: nucleic acid cytometry with droplet microfluidics
Authors: Clark Iain C. , Abate Adam R.
Published: May 2017

Nucleic acid cytometry using droplet microfluidics identifies and sorts single cells, virus, or free molecules based on specific “keyword” sequences.
Catalytic assembly of DNA nanostructures on a nanoporous gold array as 3D architectures for label-free telomerase activity sensing
Authors: Qiu Suyan , Zhao Fusheng , Zenasni Oussama , Li Jingting , Shih Wei-Chuan
Published: May 2017

SERS detection of 3D nanoassemblies on a nanoporous gold array (NPGA), exploring the synergy of catalytic multiplication and plasmon signal intensification.
Demonstrating the role of anchoring functionality in interfacial electron transfer dynamics in the newly synthesized BODIPY–TiO2 nanostructure composite
Authors: Aute Sunil , Maity Partha , Das Amitava , Ghosh Hirendra N.
Published: May 2017

Scheme illustrating the extent of coupling and charge recombination dynamics between BODIPY and NS-TiO2 anchoring through the catechol and resorcinol binding group.
Covalently anchored sulfamic acid on cellulose as heterogeneous solid acid catalyst for the synthesis of structurally symmetrical and unsymmetrical 1,4-dihydropyridine derivatives
Authors: Karhale Shrikrishna , Bhenki Chandrakant , Rashinkar Gajanan , Helavi Vasant
Published: May 2017

A novel heterogeneous solid acid catalyst has been prepared by covalent grafting of chlorosulphonic acid on amino-functionalized cellulose (Cell–Pr-NHSO3H).
Silica/methacrylate class II hybrid: telomerisation vs. RAFT polymerisation
Authors: Maçon Anthony L. B. , Kasuga Toshihiro , Remzi Becer C. , Jones Julian R.
Published: May 2017

RAFT and telomerisation were compared for polymethacrylate synthesis to investigate whether refining its polydispersity could lead to better silica hybrid properties.
A phenyl disulfide@CNT composite cathode for rechargeable lithium batteries
Authors: Bhargav Amruth , Patil Shravan V. , Fu Yongzhu
Published: May 2017

A phase extraction technique is used to prepare a core–sheath structured composite consisting of carbon nanotubes (CNTs) coated with a layer of phenyl disulfide (PDS, C6H5SSC6H5). The PDS@CNT paper cathode delivers a discharge capacity of 218 mA h g−1 at 1C while retaining 70% of the capacity after 150 cycles. High rate performance (180 mA h g−1 at 3C) and scalable synthesis prove its capability for energy storage applications.
Microstructure based prediction of the deformation behavior of soft collagenous membranes
Authors: Bircher Kevin , Ehret Alexander E. , Mazza Edoardo
Published: May 2017

The multiscale mechanical response of soft biological membranes is predicted with a discrete network model based on microstructural features.
Prevalence of Auditory Problems in Children With Feeding and Swallowing Disorders
Authors: Rawool Vishakha Waman
Published: May 2017

Purpose

Although an interdisciplinary approach is recommended for assessment and management of feeding or swallowing difficulties, audiologists are not always included in the interdisciplinary team. The purpose of this study is to report the prevalence of middle ear and hearing problems in children with feeding and swallowing disorders and to compare this prevalence with that in typical children.

Method

A total of 103 children were included in the study: 44 children with feeding and swallowing disorders and 59 children without any such disorders. Audiological examinations included case-history information, visualization of the ear canals through otoscopy, middle ear evaluation through tympanometry, and hearing screenings using an audiometer.

Results

The odds of excessive cerumen (p= .0000, small effect size), middle ear dysfunction (p= .0148, small effect size), and hearing screening failure (p= .0000, large effect size) were 22.14%, 2.97%, and 13.5% higher, respectively, in children with feeding and swallowing disorders compared with typically developing children.

Conclusion

The significantly higher prevalence of hearing problems in children with feeding and swallowing disorders compared with typically developing children suggests that inclusion of an audiologist on the interdisciplinary team is likely to improve overall interventional outcomes for children with feeding and swallowing disorders.
Response to de Wit et al., 2016, “Characteristics of Auditory Processing Disorders: A Systematic Review”
Authors: Moncrieff Deborah
Published: May 2017

Purpose

This letter to the editor is in response to a review by de Wit et al. (2016), “Characteristics of Auditory Processing Disorders: A Systematic Review,” published in April 2016 by
Journal of Speech, Language, and Hearing Research.

Conclusion

The author argues that the conclusions in the de Wit et al. (2016) review are unfortunate in light of advances made in the clinical diagnosis and treatment of bottom-up auditory processing disorders in children.
Co‐channel interference analysis of large‐scale distributed antenna systems with virtual cells
Authors: Liu Zhiyang , Zhao Yingxin , Wu Hong
Published: May 2017

The mean co‐channel interference in a distributed antenna system with virtual cells is studied, where a few surrounding remote antenna ports of each user form a virtual cell and serve the user. By assuming that time‐division‐multiple‐access is adopted among the users with overlapping virtual cells, the positions of active users at each time slot are modelled as a Matérn point process of type II, and an upper bound of the mean interference is derived and verified by simulation. The analysis shows that the monotonicity of mean interference depends on the path‐loss factor α, which highlights the importance of a carefully selection of virtual cell size according to the propagation environment.
High‐speed wireless infrared uplink scheme for airplane passengers’ communications
Authors: Tagliaferri D. , Capsoni C.
Published: May 2017

Hybrid visible light communication/infrared communication (VLC/IRC) systems are becoming the leading way for supplying high‐speed Internet connectivity to airplane passengers. A robust IR uplink transmission scheme is presented for in‐flight VLC/IRC systems which has the potential to support 10 Mbit/s transmission for each user in the cabin with uncoded bit error rate ≤10−6 under the assumption of line‐of‐sight communication scenario, also in the presence of misalignments between transmitter and receiver due to random movements of the passengers.
Optimal transmission switching in the stochastic linearised SCUC for uncertainty management of the wind power generation and equipment failures
Authors: Nikoobakht Ahmad , Aghaei Jamshid , Mardaneh Mohammad
Published: May 2017

This article has been withdrawn as the incorrect text was uploaded due to a technical error.
Digitale Welt: Wer kann der Treiber sein?
Authors: Ekkernkamp Axel
Published: May 2017

Der Blick auf die Themen der großen Gesundheits- und Gesundheitswirtschafts-Kongresse suggeriert, dass wir längst im Zeitalter Gesundheit 4.0 angekommen sind. Der 120. Deutsche Ärztetag in Freiburg, der Hauptstadtkongress, das Frühjahrsforum Deutsche Hochschulmedizin, die Nationale Branchenkonferenz in Warnemünde – alle beschäftigen sie sich schwerpunktmäßig mit IT-Infrastruktur und Digitalisierung. In Berlin haben sich sogar mehrere wissenschaftliche Institute zusammengetan und vier Professuren über digitales Gesundheitswesen ausgelobt.
Serie Innovative IT-Projekte: Agaplesion Diakonieklinikum Rotenburg: Auf dem Weg zum digitalen Krankenhaus
Authors: Doelfs Guntram
Published: May 2017

Der Maximalversorger setzt konsequent auf die Digitalisierung. Seit Ende 2015 gibt es eine mobile Patientendokumentation, 2017 folgen Spracherkennung für alle Ärzte und digitale Signatur. Das bringt viele Vorteile, wie Pflegedirektor Olaf Abraham und IT-Chef Claus Peter Thomsen schildern.
Logistik: Herausforderung Nachhaltigkeit
Authors: Mewis Dirk
Published: May 2017

Beleuchtung, Heizung und geräteintensive Bereiche wie OPs und Intensivstationen: Krankenhäuser haben einen enormen Energieverbrauch. Ressourcenschonendes Handeln wird deshalb immer wichtiger. Denn die Energiekosten werden in Zukunft weiter steigen.
Contracting: Energetisch sanieren ohne eigenes Kapital
Authors: Stein Konstanze , Zimmermann Dennis
Published: May 2017

Veraltete Anlagentechnik und hohe Energiekosten sind in vielen Krankenhäusern an der Tagesordnung. Häufig fehlt es an Geld, um die Gebäude energetisch zu sanieren. Mit der Dienstleistung Contracting wird dies möglich, ohne eigenes Kapital investieren zu müssen. Dabei ist das Outsourcing der Finanzierung nur einer der Vorteile.
Wissensdatenbank Technik im Gesundheitswesen: Jetzt geht’s los!
Authors: Thalmayr Maria
Published: May 2017

Am 3. Mai geht die von der FKT mit initiierte Wissensdatenbank Technik im Gesundheitswesen online. Neueste Kenntnisse, Best Practice, Kennzahlen und wissenschaftliche Arbeiten aus vier Ländern verbinden sich unter der Domain www.wtig.org zu einem allumfassenden virtuellen Informationsmedium und Nachschlagewerk für Technikmanager im Gesundheitswesen.
Accuracy of Blood Loss Measurement during Cesarean Delivery
Authors: Doctorvaladan Sahar , Jelks Andrea , Hsieh Eric , Thurer Robert , Zakowski Mark , Lagrew David
Published: May 2017

Objective This study aims to compare the accuracy of visual, quantitative gravimetric, and colorimetric methods used to determine blood loss during cesarean delivery procedures employing a hemoglobin extraction assay as the reference standard.

Study Design In 50 patients having cesarean deliveries blood loss determined by assays of hemoglobin content on surgical sponges and in suction canisters was compared with obstetricians' visual estimates, a quantitative gravimetric method, and the blood loss determined by a novel colorimetric system. Agreement between the reference assay and other measures was evaluated by the Bland–Altman method.

Results Compared with the blood loss measured by the reference assay (470 ± 296 mL), the colorimetric system (572 ± 334 mL) was more accurate than either visual estimation (928 ± 261 mL) or gravimetric measurement (822 ± 489 mL). The correlation between the assay method and the colorimetric system was more predictive (standardized coefficient = 0.951, adjusted R2 = 0.902) than either visual estimation (standardized coefficient = 0.700, adjusted R2 = 00.479) or the gravimetric determination (standardized coefficient = 0.564, adjusted R2 = 0.304).

Conclusion During cesarean delivery, measuring blood loss using colorimetric image analysis is superior to visual estimation and a gravimetric method. Implementation of colorimetric analysis may enhance the ability of management protocols to improve clinical outcomes.
Jumbocups in der Revision
Authors: von Roth Philipp , Wassilew Georgi
Published: May 2017

Extragroße zementfreie hemisphärische Pressfit-Pfannen werden als Jumbocups bezeichnet und wurden insbesondere in der letzten Dekade aufgrund ihrer einfachen Implantationstechnik häufig bei großen knöchernen Defekten eingesetzt. Durch ihre Größe füllen die Komponenten die azetabulären Defekte jedoch nur aus und tragen somit nicht zur Regeneration des knöchernen Lagers bei. Aufgrund dessen sind gerade bei diesem Implantattyp die Langzeitüberlebensraten von großem Interesse. Der vorliegende Beitrag diskutiert die zu diesem Thema vorliegende, relevante Literatur und geht auf die Operationstechnik und implantatspezifische Besonderheiten von Jumbocups ein. Jumbocups zeigen ein gutes Langzeitüberleben wobei dennoch die aseptische Lockerung die häufigste Revisionsursache und die Luxation die häufigste Komplikation darstellt. Durch die Entwicklung von alternativen meist modularen Revisionssystemen haben Jumbocups in der täglichen Praxis an Bedeutung verloren. Sie sind aber definitiv eine Benchmark für Neuentwicklungen im Bereich der Hüftendoprothetik.
Metabolic Syndrome and Aggressive Prostate Cancer at Initial Diagnosis
Authors: Di Francesco Simona , Tenaglia Raffaele
Published: May 2017

Links between metabolic syndrome and prostate cancer after androgen deprivation therapy are emerging. The aim of the research was to investigate the association of metabolic syndrome and aggressive prostate malignancy, at initial diagnosis, without the influence of hormonal treatment. Retrospective analysis of 133 patients with prostate tumor diagnosis between 2007 and 2009 was conducted. Patients with prostate cancer were subdivided in 2 groups according to Gleason score: Gleason score≥7 as high-grade prostate tumor (Group 1) and <7 (Group 2) as low-grade prostate tumor. Metabolic syndrome was defined according to International Diabetes Federation and the American Heart Association/National Heart, Lung, and Blood Institute definition. Metabolic syndrome was significantly associated with aggressive prostate cancer (OR 1.87, p<0.05) and a reduced risk of low-grade prostate cancer (OR 0.53, p<0.05) at initial diagnosis, without the influence of endocrine therapy. In our study, patients with metabolic syndrome were more likely to present with more aggressive prostate carcinoma vs. patients without metabolic syndrome. Further research should elucidate these relations in larger samples to confirm these associations and to stabilize future prevention and therapeutic strategies.
First-principles study of elastic mechanical responses to applied deformation of metal-organic frameworks
Authors: Banlusan Kiettipong , Strachan Alejandro
Published: May 2017

We use density functional theory to compute the elastic constant tensors of two families of metal-organic frameworks (MOFs) to establish relationships between their structures and mechanical properties. The Zn family consist of Zn4O centers each coordinated by six organic linkers along the ⟨100⟩ directions; we studied three linkers of increasing lengths: 1,4-benzenedicarboxylate (BDC), 4,4’-biphenyl-dicarboxylate (BPDC), and 4,4’’-terphenyl-dicarboxylate. This relatively weak connectivity leads to high anisotropy; in fact, Zn-MOFs exhibit extremely low shear modulus and are near a mechanical instability. In contrast, Zr family studied consists of Zr6O4(OH)4 centers each linked by fumarate, BDC, and BPDC ligands along the twelve ⟨110⟩ directions. The higher structural connectivity results in stiffer frameworks with lower anisotropy. The smallest Zr-MOF exhibits nearly isotropic elasticity with a Zener ratio of 1.06. The stiffest and most compliant directions of both families are directly related to the orientation of the organic linkers. Temperature has a significant effect on elastic moduli; for example, we observed reduction of average Young’s modulus and shear modulus by about 30% from 0 K to 300 K in Zn-BPDC even when it exhibits large negative thermal expansion. We find the effect of temperature to be directionally dependent, leading to an increase in anisotropy upon increasing temperature. The predicted effects of temperature and anisotropy help reconcile a longstanding discrepancy between experiments and first principles calculations.
Investigation of statistical parameters of the evolving wind wave field using a laser slope gauge
Authors: Zavadsky A. , Shemer L.
Published: May 2017

Statistical parameters of water waves generated by wind in a small scale facility are studied using extensively a Laser Slope Gauge (LSG), in addition to conventional measuring instruments such as a wave gauge and Pitot tube. The LSG enables direct measurements of two components of the instantaneous surface slope. Long sampling duration in a relatively small experimental facility allowed accumulating records of the measured parameters containing a large number of waves. Data were accumulated for a range of wind velocities at multiple fetches. Frequency spectra of the surface elevation and of the instantaneous local slope variation measured under identical conditions are compared. Higher moments of the surface slope are presented. Information on the waves’ asymmetry is retrieved from the computed skewness of the surface slope components.
Effect of reducible oxide–metal cluster charge transfer on the structure and reactivity of adsorbed Au and Pt atoms and clusters on anatase TiO2
Authors: Wang Honghong , An Taicheng , Selloni Annabella
Published: May 2017

We carried out density functional theory calculations to study the influence of oxide–metal charge transfers on the structure, energetics, and reactivity of Au and Pt atoms, dimers, and trimers adsorbed on the (101) surface of reduced anatase TiO2. Pt clusters interact much more strongly with the TiO2 support than Au clusters, and, with the exception of single Pt adatoms, generally behave as electron acceptors on reduced TiO2, whereas Au clusters can both accept and donate charge on the reduced surface. The reactivity of the supported clusters was probed by considering their interaction with CO and co-adsorbed O2. The effect of surface reduction on the interaction with CO is particularly significant when the CO adsorption site is an interfacial metal atom directly in contact with the TiO2 surface and/or in the presence of co-adsorbed O2. Pt clusters interact strongly with co-adsorbed O2 and form Pt–O2 complexes that can easily accept electrons from reduced surfaces. In contrast, Au clusters donate charge to co-adsorbed O2 even in the presence of excess electrons from a reduced support. The computed differences in the properties of the supported Pt and Au clusters are consistent with several experimental observations and highlight the important role of excess surface electrons in the behavior of supported metal catalysts on reducible oxides.
Very strong Rydberg atom scattering in K(12p)–CH3NO2 collisions: Role of transient ion pair formation
Authors: Kelley M. , Buathong S. , Dunning F. B.
Published: May 2017

Collisions between K(12p) Rydberg atoms and CH3NO2 target molecules are studied. Whereas CH3NO2 can form long-lived valence-bound CH3NO2− ions, the data provide no evidence for production of long-lived K+⋯CH3NO2− ion pair states. Rather, the data show that collisions result in unusually strong Rydberg atom scattering. This behavior is attributed to ion-ion scattering resulting from formation of transient ion pair states through transitions between the covalent K(12p) + CH3NO2 and ionic K+ + (dipole bound) CH3NO2− terms in the quasimolecule formed during collisions. The ion-pair states are destroyed through rapid dissociation of the CH3NO2− ions induced by the field of the K+ core ion, the detached electron remaining bound to the K+ ion in a Rydberg state. Analysis of the experimental data shows that ion pair lifetimes ≳10 ps are sufficient to account for the present observations. The present results are consistent with recent theoretical predictions that Rydberg collisions with CH3NO2 will result in strong collisional quenching. The work highlights a new mechanism for Rydberg atom scattering that could be important for collisions with other polar targets. For purposes of comparison, results obtained following K(12p)–SF6 collisions are also included.
New concise upper bounds on quantum violation of general multipartite Bell inequalities
Authors: Loubenets Elena R.
Published: May 2017

Last years, bounds on the maximal quantum violation of general Bell inequalities were intensively discussed in the literature via different mathematical tools. In the present paper, we analyze quantum violation of general Bell inequalities via the LqHV (local quasi hidden variable) modelling framework, correctly reproducing the probabilistic description of every quantum correlation scenario. The LqHV mathematical framework allows us to derive for all d and N a new upper bound (2d − 1)N−1 on the maximal violation by an N-qudit state of all general Bell inequalities, also, new upper bounds on the maximal violation by an N-qudit state of general Bell inequalities for S settings per site. These new upper bounds essentially improve all the known precise upper bounds on quantum violation of general multipartite Bell inequalities. For some S, d, and N, the new upper bounds are attainable.
Optical frequency comb generation by pulsed pumping
Authors: Malinowski Marcin , Rao Ashutosh , Delfyett Peter , Fathpour Sasan
Published: May 2017

A synchronously pumped Kerr cavity is proposed and studied for power-efficient frequency comb generation in optical microring resonators. The system is modeled using the Lugiato-Lefever equation. Analytical solutions are provided for an ideal case and extended by numerical methods to account for optical loss and higher orders of dispersion. It is shown that the average power requirement is reduced by the duty cycle of the pulse with respect to the conventional continuous-wave-pumped microrings, and it is significantly lower than the pulsed pumping of straight waveguides.
Enhancement of spatial resolution of terahertz imaging systems based on terajet generation by dielectric cube
Authors: Nguyen Pham Hai Huy , Hisatake Shintaro , Minin Oleg Vladilenovich , Nagatsuma Tadao , Minin Igor Vladilenovich
Published: May 2017

The terahertz (THz, 0.1–10 THz) region has been attracting tremendous research interest owing to its potential in practical applications such as biomedical, material inspection, and nondestructive imaging. Those applications require enhancing the spatial resolution at a specific frequency of interest. A variety of resolution-enhancement techniques have been proposed, such as near-field scanning probes, surface plasmons, and aspheric lenses. Here, we demonstrate for the first time that a mesoscale dielectric cube can be exploited as a novel resolution enhancer by simply placing it at the focused imaging point of a continuous wave THz imaging system. The operating principle of this enhancer is based on the generation—by the dielectric cuboid—of the so-called terajet, a photonic jet in the THz region. A subwavelength hotspot is obtained by placing a Teflon cube, with a 1.46 refractive index, at the imaging point of the imaging system, regardless of the numerical aperture (NA). The generated terajet at 125 GHz is experimentally characterized, using our unique THz-wave visualization system. The full width at half maximum (FWHM) of the hotspot obtained by placing the enhancer at the focal point of a mirror with a measured NA of 0.55 is approximately 0.55λ, which is even better than the FWHM obtained by a conventional focusing device with the ideal maximum numerical aperture (NA = 1) in air. Nondestructive subwavelength-resolution imaging demonstrations of a Suica integrated circuit card, which is used as a common fare card for trains in Japan, and an aluminum plate with 0.63λ trenches are presented. The amplitude and phase images obtained with the enhancer at 125 GHz can clearly resolve both the air-trenches on the aluminum plate and the card’s inner electronic circuitry, whereas the images obtained without the enhancer are blurred because of insufficient resolution. An increase of the image contrast by a factor of 4.4 was also obtained using the enhancer.
On cosmological constant of generalized Robertson-Walker space-times
Authors: Faghfouri Morteza , Haji-Badali Ali , Gholami Fateme
Published: May 2017

We classify (m + n)D warped product spaces (M¯,g¯) satisfying Einstein’s equation G¯=−Λ¯g¯. We show that the warping function f can determine not only the cosmological constant Λ¯ but also the cosmological constant Λ appearing in induced Einstein’s equation G=−Λh on (M2, h). Moreover, we discuss the origin of the 4D cosmological constant as an emergent effect of higher dimensional warped spaces.
Systematic search for wide periodic windows and bounds for the set of regular parameters for the quadratic map
Authors: Galias Zbigniew
Published: May 2017

An efficient method to find positions of periodic windows for the quadratic map f(x)=ax(1−x) and a heuristic algorithm to locate the majority of wide periodic windows are proposed. Accurate rigorous bounds of positions of all periodic windows with periods below 37 and the majority of wide periodic windows with longer periods are found. Based on these results, we prove that the measure of the set of regular parameters in the interval [3,4] is above 0.613960137. The properties of periodic windows are studied numerically. The results of the analysis are used to estimate that the true value of the measure of the set of regular parameters is close to 0.6139603.
Effects of Landau damping on ion-acoustic solitary waves in a semiclassical plasma
Authors: Barman Arnab , Misra A. P.
Published: May 2017

We study the nonlinear propagation of ion-acoustic waves (IAWs) in an unmagnetized collisionless plasma with the effects of electron and ion Landau damping in the weak quantum (semiclassical) regime, i.e., when the typical ion-acoustic length scale is larger than the thermal de Broglie wavelength. Starting from a set of classical and semiclassical Vlasov equations for ions and electrons, coupled to the Poisson equation, we derive a modified (by the particle dispersion) Korteweg-de Vries equation which governs the evolution of IAWs with the effects of wave-particle resonance. It is found that in contrast to the classical results, the nonlinear IAW speed (λ) and the linear Landau damping rate (γ) are no longer constants but can vary with the wave number (k) due to the quantum particle dispersion. The effects of the quantum parameter H (the ratio of the plasmon energy to the thermal energy) and the electron to ion temperature ratio (T) on the profiles of λ, γ, and the solitary wave amplitude are also studied. It is shown that the decay rate of the wave amplitude is reduced by the effects of H.
Thermoelectric phase diagram of the SrTiO3–SrNbO3 solid solution system
Authors: Zhang Yuqiao , Feng Bin , Hayashi Hiroyuki , Tohei Tetsuya , Tanaka Isao , Ikuhara Yuichi , Ohta Hiromichi
Published: May 2017

Here, we present a thermoelectric phase diagram for the SrTi1−xNbxO3 (0.05 ≤ x ≤ 1) solid solution system, which we derived from the characterization of epitaxial films. We observed two thermoelectric phase boundaries in the system, which originate from the step-like decrease in carrier effective mass at x ∼ 0.3 and from a local minimum in carrier relaxation time at x ∼ 0.5. The origins of these phase boundaries are considered to be related to isovalent/heterovalent B-site substitution: parabolic Ti 3d orbitals dominate electron conduction for compositions with x < 0.3, whereas the Nb 4 d orbital dominates when x > 0.3. At x ∼ 0.5, a tetragonal distortion of the lattice, in which the B-site is composed of Ti4+ and Nb4+ ions, leads to the formation of tail-like impurity bands, which maximizes the electron scattering. These results provide a foundation for further research into improving the thermoelectric performance of SrTi1−xNbxO3.
Photovoltaic and photo-capacitance effects in ferroelectric BiFeO3 thin film
Authors: Biswas Pranab Parimal , Chinthakuntla Thirmal , Duraisamy Dhayanithi , Nambi Venkatesan Giridharan , Venkatachalam Subramanian , Murugavel Pattukkannu
Published: May 2017

A polycrystalline BiFeO3 film on Pt/Ti/SiO2/Si was fabricated using the spin coating technique. The film shows diode-like characteristics with and without poling measured under dark conditions. However, it exhibits a switchable photovoltaic effect with light illumination under poled conditions. The measured photovoltaic effect revealed an open circuit voltage of ∼0.47 V and a short circuit current of 3.82 μA/cm2 under the illumination of 165 mW/cm2 irradiance. The studies clarified the dominant role of the depolarization field rather than the interface in the photovoltaic characteristics of the BiFeO3 film. Significantly, the photo-capacitance effect was demonstrated with a substantial enhancement in capacitance (∼45%) in Au/BiFeO3/Pt geometry, which could open up a new window for BiFeO3 applications.
Transferable and flexible resistive switching memory devices based on PMMA films with embedded Fe3O4 nanoparticles
Authors: Lin Y. , Xu H. Y. , Wang Z. Q. , Cong T. , Liu W. Z. , Ma H. L. , Liu Y. C.
Published: May 2017

We demonstrated transferable and flexible resistive switching (RS) memory devices using a nondestructive water-dissolution method. To satisfy future demands, the free-standing Al/Fe3O4-PMMA/Al devices were transferred onto various nonconventional substrates to demonstrate various features, such as flexibility, 3-D conformality, and biocompatibility. Thanks to the strong van der Waals interaction, the devices can easily conform to these substrates and normally display RS behavior even after undergoing bending tests. In particular, the memory devices with the PET substrate present excellent memory performance as well as high flexibility, including fast switching speed (<50 ns), large ROFF/RON ratio (∼4 × 105), and long retention time (>104 s). No performance degradation occurs after bending the device to different angles and up to 104 times. The RS mechanism can be attributed to the trapping/de-trapping of electrons at the sites of Fe3O4 nanoparticles. This result provides a feasible approach to achieve transferable RS memory device for future conformal and flexible electronics.