bluuebunny/crossref_metadata_2025 huggingface dataset:
Visual acuity and visual field as a function of disease duration in patients with birdshot chorioretinitis
Authors: Loeliger Jordan , Monnet Dominique , Thorne Jennifer , Imikerene Linda , Kecili Souhila , Brézin Antoine P
Published: March 2024

Background

Birdshot chorioretinitis (BSCR) is a chronic bilateral posterior uveitis, which can affect central as well as peripheral vision. The aim of this study was to assess how visual acuity and visual field evolved over time in patients with BSCR.

Methods

This was a prospective, observational, single-centre study based on data from the CO-BIRD cohort. Patient visits were categorised based on the time elapsed since the first symptoms, and groups of patients with different disease duration were defined. The main outcome measures were the best corrected visual acuity (BCVA), the mean deviation (MD) and the standard pattern deviation (PSD).

Results

The study included 447 Caucasian patients (181 males and 266 females), all of whom HLA-A29 carriers. From onset to 30 years of disease duration, the number of patients in each consecutive 5-year period was 237, 250, 196, 147, 78 and 32, respectively. Overall, the range of visual acuity and visual field results increased with disease duration. BCVA gradually decreased and showed a significant decline after 11–15 years after the first symptoms. Among the visual field indices, PSD significantly increased after 16–20 years, while MD showed a significant decline after 21–25 years. No major gender differences were found in visual outcomes, indicating comparable severity. The intereye correlations of MD and PSD were stronger than those of BCVA.

Conclusions

BSCR resulted in a large heterogeneity of visual outcomes, which increased with time. Our data provide an overview of the visual consequences of BSCR as a function of disease duration.
Potential smoke-free dividend across local areas in England: a cross-sectional analysis
Authors: Morris Damon , Gillespie Duncan , Dockrell Martin J , Cook Mark , Horton Marie , Brown Jamie , Langley Tessa Elisabeth
Published: March 2024

Background

The value that might be added to local economies each year through the money that people who smoke tobacco would save if everyone quit smoking is called the ‘smoke-free dividend’. This study aimed to estimate the value of the smoke-free dividend across local areas in England, and how it relates to the average income in those areas.

Methods

The study was a cross-sectional descriptive analysis of tobacco expenditure from the Smoking Toolkit Study (STS) matched to income and smoking prevalence data for English local authorities. The STS sample was from 2014 to 2020 and comprised 18 721 adults who smoke cigarettes. Self-reported expenditure estimates from the STS were adjusted for under-reporting. This adjustment aimed to align the total expenditure estimate with figures derived from government tax receipts and national estimates of illicit tobacco use. The smoke-free dividend is calculated as 93% of spending on legal tobacco, which is the percentage estimated to leave the local economy, plus 100% of spending on illicit tobacco.

Results

The total dividend in England is estimated to be £10.9 billion each year, which equates to £1776 per person who smokes or £246 per adult regardless of smoking status. The estimated dividend is greater in areas with lower average income, with a correlation coefficient of −0.521 (95% CI −0.629, –0.392) between the average income of local areas and the dividend per adult.

Conclusions

This study has estimated that local economies could gain a substantial dividend if everybody stopped smoking, which is larger in lower income areas, meaning that geographical economic inequalities could be reduced.
A Taxonomy and Survey on Grid-Based Routing Protocols Designed for Wireless Sensor Networks
Authors: Jain Shubhra , Verma Rahul Kumar
Published: March 2024

Minimization of energy consumption is the main attention of researchers while developing a routing protocol for wireless sensor networks, as sensor nodes are equipped with limited power supply. Virtual topology is an integral part of routing, and grid-based routing protocols are quite popular due to their simplified and efficient virtual grid topology construction. Although a list of surveys exists that either focus on routing protocols in a broader way or on other virtual topologies, none of these surveys are concerned about grid topology and grid-based routing protocols. Having this motivation in mind and considering the impact of these routing protocols on controlling and managing the energy consumption of wireless sensor networks, this article provides an expansive assessment of grid-based routing protocols based on their methodology. In this survey, the existing grid-based routing protocols are classified into two categories from the perspective of sink mobility: static sink and mobile sink. A phase-wise comprehensive overview of these routing protocols is provided in chronological order, along with their comparative analysis. Furthermore, the characteristics, design issues, and challenges of grid-based routing protocols are also provided.
Archived Cytogenetic Cell Pellets Used to Detect a BCR::ABL1 Driver Mutation Eight Years before Disease Presentation
Authors: Sasi Ramakrishnan , Spruill Michelle , Perrotta Peter L.
Published: March 2024

Evidence suggests that the earliest genetic events in the evolution of a cancer can predate diagnosis by several years or decades. In chronic myeloid leukemia (CML), the BCR::ABL1 fusion driver mutation can be present for an extended period before clinical disease manifests. The time between the BCR::ABL1 occurrence and symptom onset is referred to as the latency period. Though modeling studies predict this latency period is no more than ten years, it is still unclear how long it can be. We present a case of a patient referred for suspected CML. Both karyotype and FISH analysis identified the t(9;22)(q34;q11.2) translocation resulting in the Philadelphia chromosome formation in 98.5% of cells analyzed. The patient responded to imatinib and achieved a sustained complete hematologic and cytogenetic remission. Clinical history revealed that the same patient presented eight years previously with anemia. Various non-neoplastic conditions were excluded, and a bone marrow biopsy was performed to rule out MDS. Cytogenetic analysis at that time revealed del(20q) as the sole abnormality in all 20 cells analyzed. No treatment was given since the presence of isolated del(20q) is not considered evidence of MDS in the absence of diagnostic morphologic criteria. Retrospective FISH analysis of archived bone marrow pellets from this previous specimen revealed the presence of BCR::ABL1 in 1.8% of cells. A clonal population of cells harboring the BCR::ABL1 fusion was unambiguously detected in this patient’s archived bone marrow pellet obtained eight years before the current CML diagnosis. This case demonstrates that Carnoy’s fixed nuclear pellets stored in cytogenetic laboratories are suitable for detecting driver mutations years before disease presentation. Such archived material may be useful for the retrospective studies needed to better understand the initiation and subsequent development of hematological malignancies. By identifying individuals who are at increased risk, it may be possible to initiate preventive measures or begin treatment at an earlier stage before disease progression.
Influence of Perceived Job Demands on Professional Quality of Life and Turnover Intentions of Haematology Nurses: A Cross-Sectional Study
Authors: Tan Sheng Lian , Zhou Huaqiong , Thian Huimin J. , Della Phillip R.
Published: March 2024

Background. Haematology nurses in Singapore experience a highly stressful work environment and increased workload due to the growing number of patients and complex treatment regimens. High job demands can lead to burnout and high staff turnover rates, which compromises the quality of patient care. Aims. To assess perceived work demands, levels of social support from colleagues, professional quality of life (ProQOL), and turnover intentions among haematology nurses and examine whether demographic and occupational characteristics, perceived job demands, and support were associated with ProQOL and turnover intentions. Design. A descriptive, correlational, and cross-sectional design was used in this study. Methods. A convenience sample of 60 haematology nurses working at a tertiary hospital in Singapore completed a self-administered survey. Perceived job demands, support from colleagues, ProQOL, and turnover intentions were measured using the Copenhagen Psychosocial Questionnaire (COPSOQ III), Professional Quality of Life Scale version 5 (ProQOL5), and Turnover Intention Scale (TIS-6). Descriptive statistics, chi-square test, and multiple linear regressions were employed for data analysis. Results. Haematology nurses face high cognitive and emotional demands and receive high levels of support from colleagues at work. The majority of the participants reported moderate to high levels of compassion satisfaction (78.3%), burnout (76.7%), and secondary traumatic stress (81.7%). 53.3% of the participants expressed their intention to leave. Perceived job demands were significant predictors of haematology nurses’ ProQOL and turnover intentions. Compassion fatigue also significantly predicts turnover intentions. Conclusion. The high levels of burnout and secondary traumatic stress reported by haematology nurses highlight an urgent need to implement strategies to help nurses cope with the high work demands and reduce their levels of compassion fatigue. Implications for Nursing Management. The findings in this study can help nursing leaders understand haematology nurses’ perceived job demands and ProQOL, to develop strategies to improve the workplace environment and retention.
Elevated Serum IgA at Onset of Type 1 Diabetes in Children
Authors: Thakkar Amruta , Huang Xiaofan , Wang Johnny , Hwu Kathy , Chinn Ivan K. , Minard Charles , Hajjar Joud , Redondo Maria J.
Published: March 2024

Background. Elevated serum IgA levels have been observed in various autoimmune conditions, including type 1 diabetes (T1D). However, whether children with T1D and elevated serum IgA have unique features has not been studied. We aimed to evaluate the prevalence and characteristics associated with elevated serum IgA at the onset of pediatric T1D. Materials and Methods. We analyzed demographic, clinical, and laboratory data retrospectively collected from 631 racially diverse children (6 months–18 years of age) with T1D who had serum IgA levels measured within 90 days of T1D diagnosis. Univariable and multivariable logistic regression models were used to identify characteristics that were significantly associated with elevated versus normal IgA. Results. Elevated serum IgA was present in 20.3% (128/631) of the children with newly diagnosed T1D. After adjusting for other variables, A1c level (p=0.029), positive insulin autoantibodies (IAA) (p=0.041), negative glutamic acid decarboxylase autoantibodies (GADA) (p=0.005) and Hispanic ethnicity (p <0.001) were significantly associated with elevated serum IgA. After adjustment for confounders, the odds of elevated serum IgA were significantly increased with positive IAA (OR 1.653, 95% CI 1.019–2.679), higher HbA1c (OR 1.132, 95% CI 1.014–1.268) and Hispanic ethnicity (OR 3.279, 95% CI 2.003–5.359) but decreased with GADA positivity (OR 0.474, 95% CI 0.281–0.805). Conclusions. Elevated serum IgA is present in 20.3% of the children at T1D onset and is associated with specific demographic and clinical characteristics, suggesting a unique pathogenesis in a subset of individuals. Further studies are warranted to investigate the IgA response, its role in T1D pathogenesis, and whether these associations persist over time.
Interpectoral and Pectoserratus Plane Block vs. Local Anesthetic Infiltration for Partial Mastectomy: A Prospective Randomized Trial
Authors: Eisler Patryk , Zimmermann Stephan , Henningsson Ragnar
Published: March 2024

Background. Patients undergoing breast surgery are at risk of severe postoperative pain. Several opioid-sparing strategies exist to alleviate this condition. Regional anesthesia has long been a part of perioperative pain management for these patients. Aim. This randomized study examined the benefits of interpectoral and pectoserratus plane block (IPP/PSP), also known as pectoralis nerve plain block, compared with advanced local anesthetic infiltration. Methods. We analyzed 57 patients undergoing partial mastectomy with sentinel node dissection. They received either an ultrasound-guided IPP/PSP block performed preoperatively by an anesthetist or local anesthetic infiltration performed by the surgeon before and during the surgery. Results. Pain measured with the numerical rating scale (NRS) indicated no statistically significant difference between the groups (IPP/PSP 1.67 vs. infiltration 1.97; p value 0.578). Intraoperative use of fentanyl was significantly lower in the IPP/PSP group (0.18 mg vs 0.21 mg; p value 0.041). There was no statistically significant difference in the length of stay in the PACU (166 min vs 175 min; p value 0.51). There were no differences in reported postoperative nausea and vomiting (PONV) between the groups. The difference in postoperative use of oxycodone in the PACU (p value 0.7) and the use of oxycodone within 24 hours postoperatively (p value 0.87) was not statistically significant. Conclusions. Our study showed decreased intraoperative opioid use in the IPP/PSP group and no difference in postoperative pain scores up to 24 hours. Both groups reported low postoperative pain scores. This trial is registered with NCT04824599.
Supplementary Figure 4 from Autophagy Inhibition–induced Cytosolic DNA Sensing Combined with Differentiation Therapy Induces Irreversible Myeloid Differentiation in Leukemia Cells
Authors: Baba Tomohisa , Tomaru Utano , Hirao Atsushi , Mukaida Naofumi , Johmura Yoshikazu
Published: March 2024

Fig. S4 and its legend
Supplementary Figure 1 from Autophagy Inhibition–induced Cytosolic DNA Sensing Combined with Differentiation Therapy Induces Irreversible Myeloid Differentiation in Leukemia Cells
Authors: Baba Tomohisa , Tomaru Utano , Hirao Atsushi , Mukaida Naofumi , Johmura Yoshikazu
Published: March 2024

Fig. S1 and its legend
Data from Pain and Its Association with Survival for Black and White Individuals with Advanced Prostate Cancer in the United States
Authors: Rencsok Emily M. , Slopen Natalie , McManus Hannah D. , Autio Karen A. , Morgans Alicia K. , McSwain Lawrence , Barata Pedro , Cheng Heather H. , Dreicer Robert , Gerke Travis , Green Rebecca , Heath Elisabeth I. , Howard Lauren E. , McKay Rana R. , Nowak Joel , Pileggi Shannon , Pomerantz Mark M. , Rathkopf Dana E. , Tagawa Scott T. , Whang Young E. , Ragin Camille , Odedina Folakemi T. , Kantoff Philip W. , Vinson Jake , Villanti Paul , Haneuse Sebastien , Mucci Lorelei A. , George Daniel J.
Published: March 2024

Abstract
Bone pain is a well-known quality-of-life detriment for individuals with prostate cancer and is associated with survival. This study expands previous work into racial differences in multiple patient-reported dimensions of pain and the association between baseline and longitudinal pain and mortality. This is a prospective cohort study of individuals with newly diagnosed advanced prostate cancer enrolled in the International Registry for Men with Advanced Prostate Cancer (IRONMAN) from 2017 to 2023 at U.S. sites. Differences in four pain scores at study enrollment by race were investigated. Cox proportional hazards models and joint longitudinal survival models were fit for each of the scale scores to estimate HRs and 95% confidence intervals (CI) for the association with all-cause mortality. The cohort included 879 individuals (20% self-identifying as Black) enrolled at 38 U.S. sites. Black participants had worse pain at baseline compared with White participants, most notably a higher average pain rating (mean 3.1 vs. 2.2 on a 10-point scale). For each pain scale, higher pain was associated with higher mortality after adjusting for measures of disease burden, particularly for severe bone pain compared with no pain (HR, 2.47; 95% CI: 1.44–4.22). The association between pain and all-cause mortality was stronger for participants with castration-resistant prostate cancer compared with those with metastatic hormone-sensitive prostate cancer and was similar among Black and White participants. Overall, Black participants reported worse pain than White participants, and more severe pain was associated with higher mortality independent of clinical covariates for all pain scales.
Significance:
Black participants with advanced prostate cancer reported worse pain than White participants, and more pain was associated with worse survival. More holistic clinical assessments of pain in this population are needed to determine the factors upon which to intervene to improve quality of life and survivorship, particularly for Black individuals.
Data from Autophagy Inhibition–induced Cytosolic DNA Sensing Combined with Differentiation Therapy Induces Irreversible Myeloid Differentiation in Leukemia Cells
Authors: Baba Tomohisa , Tomaru Utano , Hirao Atsushi , Mukaida Naofumi , Johmura Yoshikazu
Published: March 2024

Abstract
Accumulating evidence indicates that various oncogenic mutations interfere with normal myeloid differentiation of leukemogenic cells during the early process of acute myeloid leukemia (AML) development. Differentiation therapy is a therapeutic strategy capable of terminating leukemic expansion by reactivating the differentiation potential; however, the plasticity and instability of leukemia cells counteract the establishment of treatments aimed at irreversibly inducing and maintaining their differentiation states. On the basis of our previous observation that autophagy inhibitor treatment induces the accumulation of cytosolic DNA and activation of cytosolic DNA-sensor signaling selectively in leukemia cells, we herein examined the synergistic effect of cytosolic DNA-sensor signaling activation with conventional differentiation therapy on AML. The combined treatment succeeded in inducing irreversible differentiation in AML cell lines. Mechanistically, cytosolic DNA was sensed by absent in melanoma 2 (AIM2), a cytosolic DNA sensor. Activation of the AIM2 inflammasome resulted in the accumulation of p21 through the inhibition of its proteasomal degradation, thereby facilitating the myeloid differentiation. Importantly, the combined therapy dramatically reduced the total leukemia cell counts and proportion of blast cells in the spleens of AML mice. Collectively, these findings indicate that the autophagy inhibition-cytosolic DNA-sensor signaling axis can potentiate AML differentiation therapy.
Significance:
Clinical effects on AML therapy are closely associated with reactivating the normal myeloid differentiation potential in leukemia cells. This study shows that autophagosome formation inhibitors activate the cytosolic DNA-sensor signaling, thereby augmenting conventional differentiation therapy to induce irreversible differentiation and cell growth arrest in several types of AML cell lines.
Identification of Enhanced Vaccine Mimotopes for the p15E Murine Cancer Antigen
Authors: Zhou Shiqi , Song Yiting , Luo Yuan , Quinn Breandan , Jiao Yang , Long Mark D. , Abrams Scott I. , Lovell Jonathan F.
Published: March 2024

Mimotopes of short CD8+ T-cell epitopes generally comprise one or more mutated residues, and can increase the immunogenicity and function of peptide cancer vaccines. We recently developed a two-step approach to generate enhanced mimotopes using positional peptide microlibraries and herein applied this strategy to the broadly used H-2Kb–restricted murine leukemia p15E tumor rejection epitope. The wild-type p15E epitope (sequence: KSPWFTTL) was poorly immunogenic in mice, even when combined with a potent peptide nanoparticle vaccine system and did not delay p15E-expressing MC38 tumor growth. Following positional microlibrary functional screening of over 150 mimotope candidates, two were identified, both with mutations at residue 3 (p15E-P3C; “3C,” and p15E-P3M; “3M”) that better induced p15E-specific CD8+ T cells and led to tumor rejection. Although 3M was more immunogenic, 3C effectively delayed tumor growth in a therapeutic setting relative to the wild-type p15E. As 3C had less H-2Kb affinity relative to both p15E and 3M, 15 additional mimotope candidates (all that incorporated the 3C mutation) were assessed that maintained or improved predicted MHC-I affinity. Valine substitution at position 2 (3C2V, sequence: KVCWFTTL) led to improved p15E-specific immunogenicity, tumor rejection, and subsequent long-term antitumor immunity. 3C, 3M, and 3C2V mimotopes were more effective than p15E in controlling MC38 and B16-F10 tumors. T-cell receptor (TCR) sequencing revealed unique TCR transcripts for mimotopes, but there were no major differences in clonality. These results provide new p15E mimotopes for further vaccine use and illustrate considerations for MHC-I affinity, immunogenicity, and functional efficacy in mimotope design.

Significance:

The MHC-I–restricted p15E tumor rejection epitope is expressed in multiple murine cancer lines and is used as a marker of antitumor cellular immunity, but has seen limited success as a vaccine immunogen. An in vivo screening approach based on a positional peptide microlibraries is used to identify enhanced p15E mimotopes bearing amino acid mutations that induce significantly improved functional immunogenicity relative to vaccination with the wild-type epitope.
Crassothonna moniliformis (Asteraceae, Senecioneae), a new species from the Albany Centre of floristic endemism, South Africa
Authors: MCKENZIE ROBERT J. , DOLD ANTHONY P.
Published: March 2024

Crassothonna moniliformis is described as a new species from the Eastern Cape province, South Africa. The species is a prostrate, succulent-leaved perennial herb distinguished from Crassothonna capensis in having slender, weak, trailing, distantly branched stems, with nodal adventitious roots developing precociously, forming diffuse patches to ±50 cm diam., with erect to ascending, usually red-purple, globose-obovoid to obovoid to subclavate leaves 10–25 mm long, and a more slender synflorescence bearing fewer capitula (1–4 per flowering shoot) with fewer ray florets (7–9) and functionally staminate peripheral disc florets. The species is geographically localised, with the known Extent of Occurrence and Area of Occupancy <10 km2, and is habitat-restricted, growing in shallow sandy sediments overlying exposed sandstone pavements among coastal thicket. The single known population is threatened by sand mining and informal housing encroachment. Based on the IUCN Red List categories and criteria, a conservation assessment of Vulnerable (VU – D2) is recommended.
On the typification of three Isoetes names (Isoetaceae, Lycopodiopsida) described from France
Authors: BOUDRIE MICHEL , ROUHAN GERMINAL , MALÉCOT VALÉRY , TROIA ANGELO
Published: March 2024

This paper deals with typification of three species names in Isoetes described from France: the lectotype previously designated for I. delalandei J.Lloyd is here superseded by another lectotype according to new evidence, and lectotypes are designated for I. echinospora Durieu and I. tenuissima Boreau. Selected specimens are preserved at ANG for I. delalandei, and at P for the two others. Scanning Electron Microscope (SEM) images of the spores, known to provide important routine characters in Isoetes, were acquired from the types, and information about the loci classici are provided. Isoetes echinospora and I. tenuissima have currently disappeared from their loci classici.
A new species of Odonaspis Leonardi, 1897 (Hemiptera: Coccomorpha: Diaspididae) from China
Authors: CHEN QIAN , JIAN QIAN , XING JICHUN
Published: March 2024

A new species of armoured scale insect (Hemiptera: Coccomorpha: Diaspididae: Aspidiotinae: Odonaspidini), Odonaspis renhuaiensis Chen, Jian & Xing sp. nov. is described and illustrated from Guizhou Province, China. The type specimens are deposited at the Institute of Entomology, Guizhou University, Guiyang, China. An identification key based on the morphology of adult females is provided to separate all the species of Odonaspis Leonardi, 1897.
A Comparison of the Impacts of Two Consecutive Double-Peaked La Niña Events on Antarctic Sea Ice in Austral Spring
Authors: Zhang Chao , Li Shuanglin , Han Zhe
Published: March 2024

Among nine La Niña events since 1980, there are seven double-peaked La Niña events that typically persist for 2 years and peak twice in the two consecutive boreal winters. In the study, the individual impacts of the first and second peak episodes of such La Niña on the Antarctic sea ice in austral spring (September–November) were compared. The results suggest a difference. The first episode induces a tripolar distribution of sea ice concentration (SIC) with a negative anomaly in the Bellingshausen Sea sandwiched with positive anomalies in the Ross Sea and the northeastern Weddell Sea. The second causes an SIC reduction in most parts of the Southern Ocean except for the eastern Ross–western Amundsen Seas where an increase is observed. Mechanistically, the first episode forces one single Rossby wave train to propagate southeastward, causing a strong cyclone anomaly over the eastern Ross–Amundsen–Bellingshausen Seas along with a weak anticyclone over the Weddell Sea. In comparison, the second La Niña excites two branches of Rossby wave trains emanating from the southeastern tropical Indian Ocean and the central equatorial Pacific, respectively, which induce three anomalous anticyclones and two anomalous cyclones over the Southern Ocean. These different atmospheric circulation anomalies shape their different sea ice distributions between the two La Niña episodes through both dynamic and thermodynamic processes. The modeling results from CAM5 verify these differences.

Significance Statement

Under global warming, the double-peaked La Niña occurs more frequently. The first and second La Niña episodes in such double-peaked La Niña are distinct from each other not only in their onset and developing mechanisms but also in their climate impacts. Based on observational analyses and model experiments, the study investigated the distinctive impacts of the first and second episodes on the austral spring Antarctic sea ice. The results reveal that the first episode excites one single southeastward-propagated Rossby wave train, while the second episode forces two branches of Rossby wave trains. These different atmospheric responses in the Southern Hemisphere shape the distinct sea ice distributions both dynamically and thermodynamically. The study also indicates the diversity of tropical–Antarctic teleconnections.
The Psychology of Left-Right Political Polarization; and an Experimental Intervention for Curbing Partisan Animosity and Support for Antidemocratic Violence
Authors: Jost John T. , Goya-Tocchetto Daniela , Kay Aaron C.
Published: March 2024

Healthy democratic polities feature competing visions of a good society. They also require tolerance, trust, and cooperation to avoid toxic polarization that puts democracy itself at risk. In the U.S., liberal-leftists and conservative-rightists differ in many attitudes, values, and personality traits, as well as tendencies to justify the unequal status quo and embrace authoritarian aggression and group-based dominance. Some of these differences imply that conflict between liberal-leftists and conservative-rightists is tantamount to a struggle for and against democratic ideals. However, these political and psychological differences between the left and the right do not necessarily mean that Americans are forever doomed to intergroup hatred and intractable political conflict. Some modest basis for optimism emerges from recent experimental interventions, including one that encourages people to identify with and justify the system of liberal democracy in the U.S.
Teacher Experiences of Restraint Events and School District Policies on the Use of Restraint with Children With Disabilities
Authors: Cramer Allie M. , Barnard-Brak Lucy , Watkins Laci , Fedewa Megan P.
Published: March 2024

Physical restraint is an emergency procedure restricting the movement of an individual and is used in events where students pose an imminent threat of physical harm to themselves or others. Students with disabilities are subjected to these procedures seven times more than typically developing students. Over the past decade, there has been substantial policy reform on the use of restraint; however, policies still vary across the country. Additionally, research on experiences of the use of and policy on restraint in school settings is incredibly limited. The current study expands the body of literature by investigating teachers’ experiences, and factors associated with experiences, of restraint events and district policy utilizing a multiple-methods survey design. One hundred eighty Prekindergarten through 12th-grade teachers working in a variety of school settings across the country completed a self-report online survey. Results revealed variability in experiences of restraint events and school district policies. While most participants reported following the district policy as written, level of education significantly impacted teachers’ adhering to the policy, wherein those with higher levels of education were less likely to follow the policy. Implications for policy and practice are provided.
Identifying femicide using the United Nations statistical framework: Exploring the feasibility of sex/gender-related motives and indicators to inform prevention
Authors: Dawson Myrna , Angus Haleakala , Zecha Angelika
Published: March 2024

According to the United Nations Office on Drugs and Crime, 55% of women and girls killed in 2022 died at the hands of intimate partners or family members, contexts indicative of femicide. The proportion of the remaining 45% of women and girls killed which involved sex or gender-related elements remains largely unknown. This is due to the lack of high-quality, gender-sensitive data collection tools and the few systematic efforts to more consistently and accurately document femicide. Information about femicide in marginalized and racialized communities is further affected because many of these deaths remain invisible in official data for women and girls who live – and die – at the intersections of race, poverty, ability, sexuality, and other social identities. Drawing from a recently released international statistical framework for measuring gender-related killings of women and girls, this article examines the presence of sex/gender-related motives and indicators in a Canadian sample, drawing data from publicly available information. Findings about the feasibility of documenting sex/gender-related motives and indicators generally and for specific groups of women and girls are discussed.
A multi-constituent model for assessing the effect of impeller shroud on the thrombosis potential of a centrifugal blood pump
Authors: Lv Shen , He Zhi-Peng , Liu Guang-Mao , Hu Sheng-Shou
Published: March 2024

Centrifugal blood pumps can be used for treating heart failure patients. However, pump thrombosis has remained one of the complications that trouble clinical treatment. This study analyzed the effect of impeller shroud on the thrombosis risk of the blood pump, and predicted areas prone to thrombosis. Multi-constituent transport equations were presented, considering mechanical activation and biochemical activation. It was found that activated platelets concentration can increase with shear stress and adenosine diphosphate(ADP) concentration increasing, and the highest risk of thrombosis inside the blood pump was under extracorporeal membrane oxygenation (ECMO) mode. Under the same condition, ADP concentration and thrombosis index of semi-shroud impeller can increase by 7.3% and 7.2% compared to the closed-shroud impeller. The main reason for the increase in thrombosis risk was owing to elevated scalar shear stress and more coagulation promoting factor-ADP released. The regions with higher thrombosis potential were in the center hole, top and bottom clearance. As a novelty, the findings revealed that impeller shroud can influence mechanical and biochemical activation factors. It is useful for identifying potential risk regions of thrombus formation based on relative comparisons.
The Life of Adam and Eve and the nature of Second Temple religious devotion: Can Satan be trusted concerning the worship of Adam?
Authors: Winn Adam
Published: March 2024

The Life of Adam and Eve contains an episode in which Satan describes the protoplast Adam receiving worship from the angels of heaven, worship commanded by God himself. This tradition has played a role in recent debates over the nature of Second Temple religious devotion to the God of Israel. In particular, it has been put forward as an example that undermines arguments that Israel’s God alone was the exclusive recipient of Jewish cultic worship. Within this debate, the reliability of Satan as a narrator within the Life of Adam and Eve has yet to be considered. Demonstrating Satan to be an unreliable narrator would have significant implications for the role of the Life of Adam and Eve in the debate regarding the nature of Jewish religious devotion.
Film, observation and the mind
Authors: Evans Bonnie , Harbord Janet
Published: March 2024

This special issue considers the significance of film to the establishment and development of scientific approaches to the mind. Bonnie Evans explores how the origins of film technologies in 1895 in France encouraged a series of innovative collaborations, influencing both psychological theorisation, and new filming techniques. Jeremy Blatter explains how Harvard psychologist Hugo Münsterberg created early films specifically designed to engage audiences using psychological tactics. Scott Curtis’ article examines how Yale psychologist Arnold Gesell was able to extract scientific data from a film. Felix Rietmann’s article explores a collection of infant observation films from the 1930s and 1960s and how they developed unique narratives of mothers’ engagement with their children that did not necessarily match up with dominant scientific theories. Janet Harbord's article considers how a trilogy of films made at the Maudsley Hospital in the 1950s engaged with innovative film-making techniques that captured behaviour as discrete units. Seth Watter further examines how William S. Condon's use of the unique technology of the Bell and Howell 173BD projector in the 1960s created new understandings of human behaviour that could not have been predicted in advance, and which were highly influenced by the technology itself. Finally, Des O’Rawe explores how radical approaches in both anti-psychiatry, and documentary film-making in the 1960s created new opportunities for audiences to engage with different psychological states. All of these developments in film and psychology continue to influence understandings in both these fields to the present day.
Factors contributing to the promotion of moral competence in nursing
Authors: Wiisak Johanna , Stolt Minna , Igoumenidis Michael , Chiappinotto Stefania , Gastmans Chris , Keogh Brian , Mertens Evelyne , Palese Alvisa , Papastavrou Evridiki , Mc Cabe Catherine , Suhonen Riitta ,   On behalf of the PROMOCON consortium
Published: March 2024

Ethics is a foundational competency in healthcare inherent in everyday nursing practice. Therefore, the promotion of qualified nurses’ and nursing students’ moral competence is essential to ensure ethically high-quality and sustainable healthcare. The aim of this integrative literature review is to identify the factors contributing to the promotion of qualified nurses’ and nursing students’ moral competence. The review has been registered in PROSPERO (CRD42023386947) and reported according to the PRISMA guideline. Focusing on qualified nurses’ and nursing students’ moral competence, a literature search was undertaken in January 2023 in six scientific databases: CINAHL, Cochrane Library, PsycINFO, PubMed Medline, Scopus and Web of Science. Empirical studies written in English without time limitation were eligible for inclusion. A total of 29 full texts were retrieved and included out of 5233 citations. Quality appraisal was employed using Joanna Briggs Institute checklists and the Mixed Method Appraisal Tool. Data were analysed using inductive content analysis. Research about the factors contributing to the promotion of qualified nurses’ and nursing students’ moral competence is limited and mainly explored using descriptive research designs. The contributing factors were identified as comprising two main categories: (1) human factors, consisting of four categories: individual, social, managerial and professional factors, and ten sub-categories; and (2) structural factors, consisting of four categories: educational, environmental, organisational and societal factors, and eight sub-categories. This review provides knowledge about the factors contributing to the promotion of qualified nurses’ and nursing students’ moral competence for the use of researchers, nurse educators, managers, organisations and policymakers. More research about the contributing factors is needed using complex intervention, implementation and multiple methods designs to ensure ethically sustainable healthcare.
What do We Know About Men and Masculinities in Hong Kong? A Scoping Review and Content Analysis
Authors: Tam Ho Chung , Kwan Crystal
Published: March 2024

In this review, we critically examine existing literature on men and masculinities in Hong Kong, focusing on Hong Kong Chinese masculinity. We employ a five-stage scoping review methodological framework, and analyzed twenty-five relevant studies. We identified themes such as breadwinner masculinity, work, family, social respectability, and manifestations of soft masculinity. The findings highlight the importance of masculinity for men’s well-being, and the need for further research. Specifically, age-specific studies, nuanced exploration of gender dynamics, and the interplay between family dynamics and masculinity. We also advocate for more focused examinations beyond the generic concept of “Chinese masculinity.” Our findings inform future research, interventions, and initiatives addressing masculinities in Hong Kong and beyond.
Peroneus Brevis to Longus Tendon Transfer in the Treatment of Flexible Progressive Collapsing Foot Deformity: A Cadaveric Study
Authors: Conti Matthew S. , Kim Jaeyoung , Hoffman Jeffrey , Jones Carroll P. , Ellis Scott J. , Deland Jonathan T. , Steineman Brett
Published: March 2024

Background:

Although operative treatment of the flexible progressive collapsing foot deformity (PCFD) remains controversial, correction of residual forefoot varus and stabilization of the medial column are important components of reconstruction. A peroneus brevis (PB) to peroneus longus (PL) tendon transfer has been proposed to address these deformities. The aim of our study was to determine the effect of an isolated PB-to-PL transfer on medial column kinematics and plantar pressures in a simulated PCFD (sPCFD) cadaveric model.

Methods:

The stance phase of level walking was simulated in 10 midtibia cadaveric specimens using a validated 6–degree of freedom robot. Bone motions and plantar pressure were collected in 3 conditions: intact, sPCFD, and after PB-to-PL transfer. The PB-to-PL transfer was performed by transecting the PB and advancing the proximal stump 1 cm into the PL. Outcome measures included the change in joint rotation of the talonavicular, first naviculocuneiform, and first tarsometatarsal joints between conditions. Plantar pressure outcome measures included the maximum force, peak pressure under the first metatarsal, and the lateral-to-medial forefoot average pressure ratio.

Results:

Compared to the sPCFD condition, the PB-to-PL transfer resulted in significant increases in talonavicular plantarflexion and adduction of 68% and 72%, respectively, during simulated late stance phase. Talonavicular eversion also decreased in simulated late stance by 53%. Relative to the sPCFD condition, the PB-to-PL transfer also resulted in a 17% increase ( P = .045) in maximum force and a 45-kPa increase ( P = .038) in peak pressure under the first metatarsal, along with a medial shift in forefoot pressure.

Conclusion:

The results from this cadaver-based simulation suggest that the addition of a PB-to-PL transfer as part of the surgical management of the flexible PCFD may aid in correction of deformity and increase the plantarflexion force under the first metatarsal.

Clinical Relevance:

This study provides biomechanical evidence to support the addition of a PB-to-PL tendon transfer in the surgical treatment of flexible PCFD.
Predictors of second language willingness to communicate among US undergraduate students: Classroom social climate, emotions, and language mindset
Authors: Wang Hui , Patterson Meagan M. , Peng Anqi
Published: March 2024

Teachers and scholars argue that willingness to communicate is crucial to language learning, but many language learners are reluctant to engage in such communication, in or out of class. In addition, much of the existing research on willingness to communicate is based on English language learners, but there are meaningful motivational and structural differences in English learning versus learning languages other than English. The purpose of the present study was to examine the impact of classroom social climate, language mindset, and academic emotions (i.e. anxiety, boredom, enjoyment, and pride) on second language willingness to communicate (L2WTC) in and out of class among 547 undergraduate students learning languages other than English in the United States. Analysis using structural equation modeling indicated that the emotions of anxiety, boredom, and enjoyment were associated with students’ L2WTC in class. In addition, although classroom social climate and language mindset did not have direct effects on L2WTC in class, both showed indirect effects on L2WTC in class through emotions, especially enjoyment. The findings also showed that students’ L2WTC inside the classroom relates to self-reported readiness to use the second language (L2) outside of class.
Evidentiary value and evidentiary status of blockchain evidence
Authors: Su Zelin
Published: March 2024

Blockchain evidence is a technical method for evidence storage, transmission and fixation. Its evidential value has a dual nature, reflected in the fact that it cannot be absolutely tamper-resistant, can only provide periodic assurance of evidence authenticity and the commonly used consortium chains do not possess all the benefits of public chains. Simultaneously, blockchain evidence occupies a unique status within the entire evidence system, it serves as an evidentiary storage mechanism, is essentially an electronic evidence reflecting both the evidence collection process and outcome and its notarisation and forensic examination documents are a type of opinion evidence. It is evident that blockchain evidence does not emerge in a vacuum, rather than serving as a mere replacement for traditional evidence, blockchain evidence represents an upgrade in the functionality and effectiveness of traditional evidence. From this perspective, the improvement of blockchain evidence rules should align with the basic position of ‘technological neutrality’, which means that although technological evolution can lead to rapid changes, legislators are not always required to cater to these dynamic demands. It is essential to distinguish between on-chain and off-chain when addressing issues of authenticity, hearsay and originality, and improvements proposing should within the frameworks of existing electronic evidence rules and opinion evidence rules, thereby unlocking the potential of blockchain evidence.
The use of a digital life story to support person-centred care of older adults with dementia: A scoping review
Authors: Dellkvist Helén , Dallora Ana Luiza , Christiansen Line , Skär Lisa
Published: March 2024

Introduction

A life story (LS) is a tool healthcare professionals (HCPs) use to help older adults with dementia preserve their identities by sharing their stories. Applied health technology can be considered a niche within welfare technology. Combining technology and nursing, such as using life stories in digital form, may support person-centred care and allow HCPs to see the person behind the disease.

Objective

The study's objective was to summarise and describe the use of life stories in digital form in the daily care of older adults with dementia.

Methods

A scoping review was conducted in five stages. Database searches were conducted in Cinahl, PubMed, Scopus, Web of Science, and Google Scholar; 31 articles were included. A conventional qualitative content analysis of the collected data was conducted.

Results

The qualitative analysis resulted in three categories: (1) benefits for older adults, (2) influence on HCPs’ work, and (3) obstacles to implementing a digital LS in daily care.

Conclusion

Older adults with dementia can receive person-centred care through a digital LS based on their wishes. A digital LS can enable symmetric communication and serve as an intergenerational communication tool. It can be used to handle behavioural symptoms. Using a digital LS in the later stages of dementia may differ from using it earlier in dementia. However, it may compensate for weakening abilities in older adults by enhancing social interaction.
A Study on Mobile Phone Technology Adoption & Usage Among Urban Poor Women in Resettlement Sites
Authors: Rekha P. , Don Bosco Sunitha , Van Eerd Maartje , Velayutham C.
Published: March 2024

Digital transformation and the use of interconnected digital technologies have opened up new opportunities across the world and hold promises for enhanced productivity and development for all. However, research from around the globe has proven that urban poor women are less likely to be digitally active, limiting the realization of its benefits. This study provides an insight into the mobile phone technology experiences of urban poor women at the resettlement site Perumbakkam in Chennai, India. A purposively selected group of women from the resettlement site participated in a workshop that focused on the usage of mobile technology. Post-workshop, the shared experiences of these marginalized women have provided insight into the interactions between gender and communication technology at resettlement sites. The researchers discovered that there was a growing awareness and recognition among the women about how technology could benefit their lives. They expressed eagerness to learn more about utilizing the new technology, particularly for economic improvement. However, structural barriers, particularly patriarchal gender norms, have thus far hindered women from fully harnessing the potential of mobile technology.