bluuebunny/crossref_metadata_2025 huggingface dataset:
Multilevel management of the development of the regional inclusive education system
Authors:   Yaroslavl Boarding School № 7, Zhavoronkova Liliya V.
Published: July 2022

The article raises the problem of development management of inclusive education at all levels of the education system in the region. In considering its theoretical foundations, attention is paid to the concepts of «inclusive education for students with disabilities», «regional system of inclusive education», multi-level management of the development of regional inclusive education. Problems are stated, the solution of which is necessary for the development of inclusive processes in regional education systems. Arguments are presented that justify the need to create conditions for managing the development of inclusive education at the regional and municipal levels, in an educational organization and in a primary children's team. The general goal and objectives of managing the development of the regional system of inclusive education, as well as those specific for the regional and municipal levels, the level of the educational organization and the primary children's team, are identified. A set of conditions is described that ensure the effectiveness of development management of the regional system of inclusive education at different levels of government, including: monitoring the development of the system of inclusive education, which contributes to the adoption of managerial decisions based on objective information at the regional and municipal levels of management, in the educational organization and the primary children's team; coordinated design and common value bases at all levels of management, ensuring the achievement of the common goal of inclusive education for children with special educational needs; scientific and methodological support that contributes to solving urgent problems of educational inclusion in the region; continuous training of teachers and teaching staff of inclusive schools capable of working in a new socio-cultural situation; interaction of subjects of different levels of management involved in accompanying children with disabilities, and coordination of their activities.
UTILIZATION OF ANTHOCYANIN IN EDIBLE FILM AS COCONUT MILK FRESHNESS INDICATOR
Authors: Fauzan Utary Nur Rachmani , Astrinida Rizkina Dwi Pancani  , Fitria Yulistiani  , Nancy Siti Djenar
Published: July 2022

Technology in smart packaging continues to evolve, one of which is packages equipped with food freshness indicators to monitor food safety and quality. These indicators can be formed by immobilizing anthocyanin into edible film and then changing its color to pH changes.  The research aims to determine the immobilization time, test the color stability of the edible film indicator to temperature changes, determine the characterizations of the edible film indicator based on the %relative standard deviation (%RSD) value, and apply the edible film indicators as coconut milk freshness indicators. The best immobilization time was in the 90th minute with %RSD=0%. The edible film indicators did not change color from 10 to 50°C with %RSD=0%. The characterizations of edible film indicators on pH 6, 7, 8, and 10 had response times of 6.68 minutes; 9.49 minutes; 3.57 minutes; and 4.37 minutes; periods of 14 days, 13 days, 14 days, and 16 days; and good reproducibility at pH 6 and 10 and not good at pH 7 and 8. Overall, based on anthocyanin color changes, an edible film indicator can be used as a freshness indicator in coconut milk but cannot indicate the pH value of coconut milk.
EFFECT OF SULFURIC ACID CONCENTRATION ON NICKEL RECOVERY FROM LATERITE ORE BY USING ATMOSPHERIC ACID LEACHING METHOD
Authors: Althafa Muntaqin  , Lutfiah Rahmasari  , Ninik Lintang Edi Wahyuni  , Rony Pasonang Sihombing
Published: July 2022

The processing of laterite ore by pyrometallurgy requires high temperatures whereas the Atmospheric Acid Leaching (AAL) method can be performed below 100 ℃ although its nickel recovery is inconsistent. This research aims to determine the effect of sulfuric acid concentration on nickel recovery and to determine nickel recovery after extract purification by precipitation of non-nickel metals. AAL was performed with an operating temperature of 95 °C, an operating time of 5 hours, an ore-to-solvent ratio of 0.05 g/ml, a particle size of ± 200 mesh, and sulfuric acid concentration variation of 0.2–1 M. Iron precipitation was completed with a pH variation of 0.5–3.8 by the addition of ammonia. The result showed that the concentration of sulfuric acid increased nickel recovery. The nickel recovery reached 96.43% at a concentration of sulfuric acid of 1 M. Furthermore, after extract purification, nickel recovery reached 50.61%, which was achieved at an optimum pH of 3.2.
UTILIZATION OF BLOTONG, MOLASSES, BRAN, AND COCONUT HUSK INTO COMPOST USING MOL OF STALE RICE AND Trichoderma sp.
Authors: Huda Hilda Fitria Nurul , Fakhirah Ramadhani Putri , Kusumawati Endang , Ghozali Mukhtar
Published: July 2022

Compost is a solution for dealing with organic waste. Compost with organic material must be mixed according to its elemental composition. Protein and potassium are obtained from bran and coconut husk. Blotong contains phosphorus (P), while molasses contains total N and K2O. Local Microorganisms (MOL) of stale rice is an activator to increase the microbiological decomposition of organic matter and contains Saccharomyces cerevisiae, Bacillus cereus, and Aspergillus sp. The addition of Trichoderma sp. can speed up the composting process. The aim of the study is to determine the effect of adding Blotong and bran on the quality of compost, to obtain the most effective composition of Blotong, molasses, bran, and coconut husk for composting using MOL activator of stale rice and Trichoderma sp. according to SNI 7763:2018, and to determine the most effective composting time. The ratio of Blotong, coconut husk, bran, and molasses for the three variations were 56:10:30:4; 66:10:20:4; and 76:10:10:4 in percent as much as 6 kg calculated with Takakura method. The result of the study showed the three variations had fulfilled SNI 7763:2018 in 18 days, with the most effective composition is the 3rd variation.
MOLECULAR DOCKING COMPOUNDS IN METHANOL EXTRACT OF MANGO LEAVES (Mangifera indica L.) AS ANTI-INFLAMMATORY AGENT
Authors: Anggraeni Vina Juliana , Purwaniati Purwaniati , Budiana Wempi , Nurdin Thoriq
Published: July 2022

Previous studies have shown that mango has anti-inflammatory properties. Anti-inflammatory drugs are compounds or medicines used to treat diseases caused by inflammation. The most commonly used anti-inflammatory drug is a non-steroidal anti-inflammatory drug (NSAID). The drug works by inhibiting the enzyme cyclooxygenase (COX). The purpose of this study was to determine the profile metabolites present in the methanol extract of mango leaves and their interaction with the COX enzyme. This study includes an analysis of the compounds contained in the methanol extract of mango leaves using LCMS / MS and molecular docking studies of these compounds. Compounds detected by MS include C26H24O14, C45H84O14, Khellol-β-D-glucoside, Mangiferin, and Nevadensin-5-β-D-glucoside. Analysis of docking result was based on ΔG and Ki and the binding interactions that occur. Compounds that are compatible with COX1 and COX2 are Khellol βD glucoside with G and Ki values of 7.49 kcal/mol and 3.23 µM and 8.32 kcal/mol and 0.7919 µM, respectively. Through the molecular docking process, it was confirmed that khellol β-D-glucoside may be activated as an anti-inflammatory agent.
FORMULATION AND EVALUATION OF ANTI-INFLAMMATORY EMULGEL OF Brucea javanica (L.) Merr SEED EXTRACTS
Authors: Muliasari Handa , Almira Diva , Anugrah Subaidah Windah
Published: July 2022

Anti-inflammatory drugs are needed to overcome excessive inflammatory reactions that can interfere with activities. The existence of side effects in the use of synthetic anti-inflammatory drugs causes the search for natural drugs with high therapeutic effects and low side effects to continue. Seeds of Makassar (Brucea javanica (L.) Merr) plant are known to have anti-inflammatory activity. Topical anti-inflammatory administration is currently being developed because it can minimize side effects compared to oral. This study aimed to formulate 96% ethanol extract of Makasar fruit seeds in the form of an emulgel and to determine the physical properties and anti-inflammatory activity of the emulgel in vitro. Makasar fruit seeds were extracted by sonication method using 96% ethanol solvent (3 x 35 minutes). The extract was then formulated into an emulgel preparation with an extract concentration of 1%. Emulgel was then tested for its physical properties and anti-inflammatory activity in vitro using protein denaturation inhibition method. The results showed that the physical properties of emulgel base (F0), extract emulgel (F1), and Na-diclofenac emulgel (F2) met the requirements for homogeneity, pH, adhesion, spreadability, and viscosity tests. F0, F1, and F2 had inhibition percentages of 3.74±1.58%,; 23.07±0.72%; and 33.49±0.29, respectively. According to one-way ANOVA statistical test, the three tested groups had significant differences.
EFFECT OF CHEMICAL AND MICROWAVE HEATING TREATMENT FOR REDUCING SUGAR RECOVERY
Authors: Rahkadima Yulia Tri , Fitri Medya Ayunda
Published: July 2022

Microwave heating treatment was the one type of pretreatment process used in the manufacture bioethanol because it can be applied singly or in combination with other chemicals. The purpose of this study was to determine the effect of microwave heating on the pretreatment process using acid and alkaline solvents. The research was carried out in two stages, namely the preparation of raw materials and pretreatment with microwave. At the stage of preparation of raw materials, bagasse was dried for 2 days and then crushed to a size of 50 mesh to uniform the size of the raw materials. The raw materials that have been prepared are then subjected to a pretreatment process. The pretreatment process was carried out using a modified microwave with temperature settings and the addition of a stirrer. 5 grams of bagasse powder and 200 ml of a solution of H2SO4 or NaOH (0.2 M, 0.4 M, and 1 M) were put into a round tool flask and then put into the microwave. Pretreatment was carried out at 180°C with time variables of 10, 15, 20, 25, and 30 minutes. Then the solution was separated from the residual solid by filtration and the solution was neutralized with 1 M HCl. The results showed that the use of acidic and alkaline solvents, high concentrations of solvents can lead to smaller the acquisition of reducing sugars in the liquid product phase. The highest percentage of reducing sugar obtained is 0.559% when using an acid solvent with a concentration of 0.1 M for 20 minutes.
Species-specific dechlorane plus isomer fractionation during bioaccumulation: phenomenon and potential mechanisms
Authors: Guan Ke-Lan , Liu Hong-Ying , Luo Xiao-Jun
Published: July 2022

The occurrence and behavior of dechlorane plus (DP), an additive chlorinated flame retardant, have been intensively studied since it was identified in 2006. The commercial products of DP are a mixture of two stereoisomers: syn-DP and anti-DP. Stereoselective bioaccumulation of DP isomers in biota was reported in field monitoring and laboratory experiments. This review summarizes stereoselective bioaccumulation of DP in biota samples and provides the potential mechanisms for this stereoselective bioaccumulation. Stereoselective enrichment of syn-DP was widely observed in fish, whereas selective enrichment of anti-DP was mainly found in some birds. This species-specific stereoselective enrichment of DP might reflect that two different types of DP isomer fractionation occurred in bioaccumulation between ectotherms and endotherms. Anti-DP is more readily metabolized through biotransformation in all animals. However, a preferential excretion of anti-DP in fish and syn-DP in birds was observed based on the available data. Both processes determine the DP isomer fractionation in bioaccumulation. A direct comparison in DP composition between biological samples and commercial products was conducted for most studies to determine the occurrence of stereoselective DP enrichment, which may lead to underestimating the potential stereoselective enrichment of DP in organisms. The factors which affected the DP isomer composition in organisms included the tissues or organs used, DP concentration, organisms’ trophic levels occupied, and sex. Inconsistent results were obtained considering the effects of these influence factors. The underlying cause of these inconsistent results is unclear based on present data. Further research on DP biotransformation and interactions between DP and biomacromolecule is needed.
PEMANFAATAN LIMBAH SASIRANGAN SEBAGAI SUMBER BELAJAR UNTUK MENINGKATKAN LITERASI ILMIAH DAN HASIL BELAJAR SISWA DENGAN PENERAPAN MODEL PEMBELAJARAN GROUP INVESTIGATION (GI) PADA MATERI KOLOID
Authors: Sa’diah Noor , Sholahuddin Arif , Mahdian Mahdian
Published: July 2022

Telah dilakukan penelitian tentang penerapan model pembelajaran Group Investigation (GI) dengan pemanfaatan limbah sasirangan sebagai sumber belajar pada materi koloid siswa kelas XI IPA SMA Negeri 11 Banjarmasin. Penelitian ini bertujuan untuk mengetahui : (1) perbedaan literasi ilmiah antara siswa kelas eksperimen dan kelas kontrol, (2) perbedaan hasil belajar kognitif antara siswa kelas eksperimen dan kelas kontrol dan (3) respon siswa terhadap penerapan model Group Investigation (GI) pada materi koloid. Penelitian ini menerapkan metode eksperimen semu (quasy experiment) dengan pretest-posttest control group design. Sampel penelitian adalah kelas XI IPA 2 sebagai kelas eksperimen dan XI IPA 3 sebagai kelas kontrol. Terdapat dua variabel penelitian yaitu model pembelajaran Group Investigation (GI) dengan pemanfaatan limbah sasirangan sebagai sumber belajar sebagai variabel bebas, literasi sains dan hasil belajar sebagai variabel terikat. Kelas eksperimen menerapkan model Group Investigation (GI) dengan pemanfaatan limbah sasirangan sebagai sumber belajar, sedangkan kelas kontrol menerapkan model konvensional. Pengumpulan data menggunakan teknik tes dan kuesioner. Teknik analisis data menggunakan analisis deskriptif dan analisis inferensial. Hasil penelitian menunjukkan (1) terdapat perbedaan literasi ilmiah yang signifikan antara siswa kelas eksperimen dengan rata-rata 86,48 dan kelas kontrol dengan rata-rata 68,57, (2) terdapat perbedaan hasil belajar kognitif yang signifikan antara siswa kelas eksperimen dengan persentase ketuntasan 82,85 % dan kelas kontrol dengan persentase ketuntasan 71,43 %, (3) model pembelajaran Group Investigation (GI) dengan pemanfaatan limbah sasirangan sebagai sumber belajar mendapat respon positif dari siswa pada materi koloid dengan rata-rata respon siswa 42,57 yang termasuk kategori sangat baik.
MENINGKATKAN SELF EFFICACY DAN KETERAMPILAN BERPIKIR KRITIS DENGAN MODEL PEMBELAJARAN INKUIRI TERBIMBING BERBANTUAN VIRTUAL LABORATORY PADA MATERI LARUTAN PENYANGGA
Authors: Maulidah Agusnita , Rusmansyah Rusmansyah , Leny Leny
Published: July 2022

Telah dilakukan penelitian tentang meningkatkan self efficacy dan keterampilan berpikir kritis dengan model pembelajaran Inkuiri Terbimbing berbantuan virtual laboratory pada materi larutan penyangga pada siswa kelas XI IPA 1. Penelitian ini bertujuan untuk mengetahui: (1) aktivitas guru; (2) aktivitas siswa; (3) self efficacy; (4) keterampilan berpikir kritis; (5) hasil belajar; (6) respon siswa dengan model pembelajaran Inkuiri Terbimbing berbantuan virtual laboratory. Metode yang digunakan ialah rancangan PTK yang terdiri dari 2 siklus. Peneliti menggunakan subjek penelitian yaitu siswa kelas XI IPA 1 SMA PGRI 4 Banjarmasin dengan jumlah 36 orang. Instrumen penelitian berupa tes dan non tes. Hasil  dari penelitian menyatakan bahwa (1) aktivitas guru sebesar 42,67 kategori baik di siklus I menjadi 50,27 dalam kategori sangat baik di siklus II, (2) aktivitas siswa sebesar 39 kategori aktif di siklus I menjadi 48,33 dalam kategori sangat sangat aktif di siklusII, (3) peningkatan terjadi pada self efficacy siswa berdasarkan hasil observasi sebesar 125,12 kategori cukup baik di siklus I menjadi 133,08 kategori baik di siklus II, (4) peningkatan terjadi pada keterampilan berpikir kritis berdasarkan hasil evaluasi secara klasikal dari 60,43% dengan kategori cukup kritis di siklus I menjadi 83,61% dengan kategori sangat kritis pada siklus II, (5) peningkatan terjadi pada ketuntasan hasil belajar kognitif secara klasikal dari 30,56% di siklus I menjadi 86,11% pada siklus II, hasil belajar afektif meningkat berdasarkan hasil observasi sebesar 122,67 dari kategori cukup baik di siklus I menjadi 141, 32 dengan kategori baik di siklus II, (6) respon positif terhadap pembelajaran dengan model inkuiri terbimbing berbantuan virtual laboratory.
A Theoretical Analysis of the Transient Fluctuation Theorem for Accelerated Colloidal Systems in the Long-Time Limit
Authors: Lokare Yash
Published: July 2022

A quantitative description of the second law of thermodynamics in small scale systems and over short time scales comes from various fluctuation theorems. The applicability of the transient fluctuation theorem in particular to small scale systems perturbed from an initial equilibrium steady-state distribution has been demonstrated both theoretically and experimentally in several works over the past few decades. In addition, some experimental works in the past have also made successful attempts to demonstrate the applicability of the fluctuation theorem to small scale systems evolving from a certain nonequilibrium steady-state distribution over relatively long time scales. To this end, this paper seeks to demonstrate the transient fluctuation theorem for a Brownian particle confined within a power-law trapping potential by following the trajectory of the particle that itself is translating linearly along one dimension with constant acceleration in a viscous fluid. Considered herein is an idealized version of this model, in that it is assumed that the force of the trapping potential is only felt by the translating Brownian particle confined within the trap, and that this Brownian particle moves relative to the fluid molecules that are held stationary. The results presented herein show that the transient fluctuation theorem applies not only to equilibrium steady-state distributions but also to nonequilibrium steady-state distributions of an ideal colloidal system in an accelerated frame of reference in the asymptotic (long-time) limit.
Monkeypox: A New Threat?
Authors: Kmiec Dorota , Kirchhoff Frank
Published: July 2022

The global vaccination programme against smallpox (SPX) led to its successful eradication and averted millions of deaths. Monkeypox (MPX) is a close relative of SPX. Due to their antigenic similarity, SPX vaccines cross-protect against MPX. However, over 70% of people living today were never vaccinated. Symptoms of MPX infection include fever, head and muscle ache, lymphadenopathy and a characteristic rash that develops into papules, vesicles and pustules which eventually scab over and heal. MPX is less often fatal (case fatality rates range from less than 1% to up to 11%) than SPX (up to 30%). MPX is endemic in sub-Saharan Africa, infecting wild animals and causing zoonotic outbreaks. Exotic animal trade and international travel combined with the increasing susceptibility of the human population due to halted vaccination facilitated the spread of MPX to new areas. The ongoing outbreak with over 6500 confirmed cases in >50 countries between May and July 2022 shows that MPX can significantly spread between people, and may thus become a serious threat to public health with global consequences. Here, we summarize the current knowledge about this re-emerging virus, discuss available strategies to limit its spread and pathogenicity and evaluate its risk to the human population.
Water Consumption Habits of a North-Western Turkish Community: A Cross-Sectional Study
Authors: Ayranci Ünal , Yildiz Merve sezer , Demirci Ahmet
Published: July 2022

The aim were to determine the drinking water preferences of people applied to a family health center. This cross-sectional study was carried out from April 01st to May 31st, 2022. The data were evaluated using the chi-square test and percent ratios with a significant of P < 0.05. The mean age of all 432 respondents was 48.03±15.86. It was determined that those aged 31-45 had drunk more bottled water (p<0.01) and more spring water (p<0.001), that those aged 65 and over more purified water (p<0.001), that women more tap water (p<0.001), that married people had drunk more demijohn and tap water (p<0.001, each one), that divorced/widows had drunk more packaged and purified water (p<0.001, each one), that the illiterate/literate bottled water (p<0.001, per one), that those who had no income/people who lived on the state or municipal assistance only carboy water (p<0.001). This study suggests that the biggest factor that positively affected the drinking water preference was the packaging of the water. However, the drinking rates of mains water and spring water were quite low. Convincing the authorities to make the mains water drinkable is of great importance in terms of overcoming the public's distrust of mains water.
Deep Learning to Near-Surface Humidity Retrieval from Multi-sensor Remote Sensing Data over the China Seas
Authors: Zhang Rongwang , Guo Weihao , Li Xiaofeng , Wang Xin
Published: July 2022

Near-surface humidity (Qa) is a key parameter that modulates oceanic evaporation and influences the global water cycle. Remote sensing observations act as feasible sources for long-term and large-scale Qa monitoring. However, existing satellite Qa retrieval models are subject to apparent uncertainties due to model errors and insufficient training data. Based on in situ observations collected over the China Seas over the last two decades, a deep learning approach named Ensemble Mean of Target deep neural networks (EMTnet) was proposed to improve the satellite Qa retrieval over the China Seas for the first time. The EMTnet model outperforms five representative existing models by nearly eliminating the mean bias and significantly reducing the root-mean-square error in satellite Qa retrieval. According to its target deep neural networks selection process, the EMTnet model can obtain more objective learning results when the observational data are divergent. The EMTnet model was subsequently applied to produce a 30-year monthly gridded Qa data over the China Seas. It indicates that the climbing rate of Qa over the China Seas under the background of global warming are probably underestimated by current products.
Mitochondrial Damage-Associated Molecular Patterns Content in Extracellular Vesicles Promotes Early Inflammation in Neurodegenerative Disorders
Authors: Lopes Carla , Mota Sandra , Deus Claudia , Tavares Henrique , Beatriz Margarida
Published: July 2022

Neuroinflammation is a common hallmark in different neurodegenerative conditions that share neuronal dysfunction and a progressive loss of a selectively vulnerable brain cell population. Alongside ageing and genetics, inflammation, oxidative stress, and mitochondrial dysfunction are considered key risk factors. Microglia are considered immune sentinels of the central nervous system capable of initiating an innate and adaptive immune response. Nevertheless, the pathological mechanisms underlying the initiation and spread of inflammation in the brain are still poorly described. Recently, a new mechanism of intercellular signalling mediated by small extracellular vesicles (EVs) has been identified. EVs are nanosized particles (30-150 nm) with a bilipid membrane that carries cell-specific bioactive cargos that participate in physiological or pathological processes. Damage-associated molecular patterns (DAMPs) are cellular components recognized by the immune receptors of microglia, inducing or aggravating neuroinflammation in neurodegenerative disorders. Diverse evidence links mitochondrial dysfunction and inflammation mediated by mitochondrial-DAMPs (mtDAMPs) such as mitochondrial DNA, TFAM and cardiolipin, among others. Mitochondrial-derived vesicles (MDVs) are a subtype of EVs produced after mild damage to mitochondria and, upon fusion with multivesicular bodies (MVBs), are released as EVs to the extracellular space. MDVs are particularly enriched in mtDAMPs which can induce an immune response and the release of pro-inflammatory cytokines. Importantly, growing evidence supports the association between mitochondrial dysfunction, EVs release and inflammation. Here, we describe the role of extracellular vesicles-associated mtDAMPS in physiological conditions and as neuroinflammation activators contributing to neurodegenerative disorders.
Immersive Therapy for Improving Anxiety in Health Professionals of a Regional Hospital During the COVID-19 Pandemic: A Quasi-Experimental Pilot Study
Authors: Linares-Chamorro Marta , Domènech-Oller Neus , Jerez-Roig Javier , Piqué-Buisan Joel
Published: July 2022

Background: Immersive therapy through virtual reality represents a novel strategy used in psychological interventions, but there is still a need to strengthen the evidence on its effects on health professionals’ mental health. Objective: To analyze the results of immersive therapy through virtual reality in the levels of anxiety and secondly, well-being of the health professionals working in a regional hospital in Olot (Spain). Methods: Pilot quasi-experimental study including a group of 35 women (mean age=45.7, SD=8.43) health professionals who undertook immersive therapy for 8 weeks. The intervention was implemented through virtual reality, and its effect on anxiety levels and well-being was evaluated through the Hamilton and Eudemon scales, respectively. Data on age, gender, active pharmacological or psychological treatment, mental health disorders and number of sessions were also collected. Results: Statistically significant (p<0.001) improvement in anxiety and well-being was found, with large and moderate effect sizes (0.90 and 0.63 respectively). In addition, these changes were clinically significant. No significant associations were found between the improvements and the different variables, but a greater trend was identified among the group of professionals with untreated or unidentified levels of anxiety. Conclusion: This group of health professionals showed statistically and clinically significant improvement in anxiety and well-being after the application of immersive therapy using virtual reality. Further studies with a control group are necessary to further analyze this novel intervention.
A Density Functional Theory and Information-Theoretic Approach Study of Interaction Energy and Polarizability for Base Pairs and Peptides
Authors: Zhao Dongbo , Liu Shubin , Chen Dahua
Published: July 2022

Using density functional theory (DFT) and the information-theoretic approach (ITA) quantities to appreciate the energetics and properties of biopolymers is still an unaccomplished and ongoing task. To this end, we studied the building blocks of nucleic acid base pairs and small peptides. For base pairs, we have dissected the relative importance of energetic components by using two energy partition schemes in DFT. Our results convincingly show that the exchange-correlation effect predominantly governs the molecular stability of base pairs while the electrostatic potential plays a minor but indispensable role, and the steric effect is trivial. Furthermore, we have revealed that simple density-based ITA functions are in good relationships with molecular polarizabilities for a series of 30 hydrogen-bonded base pairs and all 20 natural α-amino acids, 400 dipeptides, and 8000 tripeptides. Based on these lines, one can easily predict the molecular polarizabilities of larger peptides, even proteins as long as the total molecular wavefunction is available, rather than solving the computationally demanding coupled-perturbed Hartree-Fock (CPHF) equation or its DFT counterpart coupled-perturbed Kohn-Sham (CPKS) equation.
Screening Biophysical Sensors and Actuators that Influence Wound Healing in Human Induced Pluripotent Stem Cell-Derived Neurons
Authors: Pai Vaibhav , Cooper Ben , Levin Michaelk
Published: July 2022

All living cells maintain a charge distribution across their cell membrane (membrane potential) by carefully controlled ion fluxes. These bioelectric signals regulate cell behavior (such as migration, proliferation, differentiation) as well as higher-level tissue and organ patterning. Thus, voltage gradients represent an important parameter for diagnostics as well as a promising target for therapeutic interventions in birth defects, injury, and cancer. However, despite much progress in cell and molecular biology, little is known about bioelectric states in human stem cells. Here, we present simple methods to simultaneously track ion dynamics, membrane voltage, cell morphology, and cell activity (pH and ROS), using fluorescent reporter dyes in living human neurons derived from induced neural stem cells (hiNSC). We developed and tested functional protocols for manipulating ion fluxes, membrane potential, and cell activity, and tracking neural responses to wounding and re-innervation in vitro. Finally, using morphology sensor, we tested and quantified the ability of physiological actuators (neurotransmitters and pH) to manipulate nerve wound re-innervation. These methods are not specific to a particular cell type and should be broadly applicable to the study of bioelectrical controls across a wide range of combinations of models and endpoints.
Philosophical Aspects of Emotion
Authors: Mun Cecilea
Published: July 2022

In this paper, I give readers an idea of what some scholars are interested in, what I found interesting, and what may be of future interest in the philosophy of emotion. I begin with a brief overview of the general topics of interests in the philosophy of emotion. I then discuss what I believe to be some of the most interesting topics in the contemporary discourse, including questions about how philosophy can inform the science of emotion, conceptions of the mind and the mind-body problem, concerns about perception, cognition, and emotion, along with questions about the place of 4E approaches and meta-semantic pluralist approaches in the embodied cognitive tradition. Finally, I discuss the emerging field of cultural evolution, the import of a dual-inheritance theory in this emerging field, and I propose a possible way to integrate the frameworks of dual-inheritance theory and meta-semantic pluralism to demonstrate at least one way in which the philosophy of emotion can contribute to the emerging field of cultural evolution.
THE EFFECT OF PERSONAL AND SITUATIONAL FACTORS ON THE INTENTION OF WHISTLEBLOWING WITH MODERATED LEGAL PROTECTION
Authors: Rahman Daisar , Hayati Nur ,   University of Trunojoyo, Madura
Published: July 2022

This research is to determine the effectiveness of legal protection in strengthening the relationship between attitude toward behavior, subjective norm, perceived behavioral control, the seriousness of wrongdoing, status of the wrongdoer, and reward with whistleblowing intentions. The population in this research was civil servants who were Regional Inspectors in all regencies in Madura. The sampling technique in this study was purposive sampling consisting of 104 civil servants who had functional positions as auditors, staffing auditors, or supervisors of regional government (P2UPD). Data was collected by distributing questionnaires directly to the respondents. The data analysis technique used in this study was PLS-SEM by using Smart-PLS 3.0 software. The results of the study found that (1) Attitude toward behavior, subjective norm, and reward affect whistleblowing intentions; (2) Perceived behavioral control, seriousness of wrongdoing, and status of the wrongdoer does not affect whistleblowing intentions; (3) Legal protection is unable to strengthen the relationship between attitude toward behavior, subjective norm, perceived behavioral control, the seriousness of wrongdoing, status of the wrongdoer, and reward with whistleblowing intentions.
DETERMINANTS OF SYSTEMATIC AND UNSYSTEMATIC LIQUIDITY RISK IN ISLAMIC BANKS
Authors: Hussain Anwar , Kijkasiwat Ploypailin , Ijaz Bushra Mobeen , Deari Fitim
Published: July 2022

This study examines whether systematic (macroeconomic) and unsystematic (bank specific) factors determine liquidity risk in Islamic banks. The study employs a sample of Islamic banks from Pakistan, Qatar, Malaysia, UAE, Bangladesh, Bahrain, and Saudi Arabia over the period 2008 – 2019. Using Least Square estimation methods to estimate the model separately for each country, we find the results to be mixed and different across countries.  The results also show that non-performing loans, bank size, leverage ratio and return on assets are key unsystematic drivers in determining the liquidity risk of Islamic banks. This study points out the fragility of Islamic banks in relation to managing liquidity risk.
Galleta de Arracacha
Authors:   , Perez Medina Anyela Yadira , De La Cruz Huaman Lisbeth Lorena
Published: July 2022

Actualmente en nuestro país, ha ido en aumento el hábito de consumo saludable por parte de los habitantes, ya que haber pasado por una pandemia y cuarentena, que puso en riesgo la salud. Es por ello que buscan opciones más saludables para el consumo diario y para lograr satisfacer sus nuevos hábitos de consumo, por otro lado, si bien en el rubro de alimentos y snacks han salido al mercado más productos naturales y saludables, no han logrado implementar productos nuevos y sobre todo con el componente principal que sea nacional, de los cuales tienen un alto valor nutritivo. Es por ello que este trabajo, consiste en la preparación de un plan de negocio para las galletas hechas a base de Arracacha, así como la harina preparada de Arracacha, este es un tubérculo que es altamente nutritivo y adecuado para todas las personas, contiene hierro, calcio, etc. Gracias la variedad de productos alimenticios que se distribuyen en el distrito de Ate se ha considera este distrito ya que, actualmente es considerado uno de los distritos con mayor población. Asimismo, hemos considerado dirigirnos a adolescentes y adultos entre los 15 a 30 años de edad, ya que las personas que están dentro de este rango de edad son las que estudian y/o trabajan. Además, se buscará fomentar el consumo y conocimiento tanto del producto como de la arracacha. Finalmente, gracias a la investigación realizada por encuestas y entrevistas, nos indicaron positivamente la intensión de consumo y compra por parte de nuestro público objetivo, es por ello que la realización de este plan de negocio y la introducción del producto al mercado es importante.
Resiliencia y estrés académico en estudiantes de secundaria del distrito de San Mateo-Huarochirí en tiempos del COVID-19
Authors:   , Huere Verastegui Suheydi Rayda
Published: July 2022

La finalidad del presente estudio fue analizar la relación entre la resiliencia y el estrés académico en estudiantes de secundaria del distrito de San Mateo en la Provincia de Huarochirí, Lima, Perú, durante la pandemia por el COVID-19. La muestra fue de tipo censal compuesta por 350 alumnos entre 12 y 18 años. El enfoque del estudio es cuantitativo de tipo básico, descriptivo y correlacional con un diseño no experimental y transversal. Los hallazgos muestran que los estudiantes presentan un nivel alto de resiliencia y moderados de estrés académico. Además, se encontró relación negativa y significativa entre la resiliencia y el estrés académico a nivel general (Rho=-,126; p<0,05) y las dimensiones estresores (Rho=-,143; p<0,05), síntomas (Rho=-,278; p<0,05) y estrategias de afrontamiento (Rho=,334; p<0,05). Estos hallazgos plantean la necesidad de planificar intervenciones centradas en fortalecer factores protectores como la resiliencia en la población estudiantil afectada por la pandemia para minimizar el efecto del estrés.
Desarrollo de pronóstico estacional y su efecto sobre la producción lechera de ganado bovino en Lima, entre 2009 - 2018
Authors:   , Veramendi Nina Frank Hildemaro
Published: July 2022

El presente estudio tuvo como objetivo describir y pronosticar el efecto de los meses sobre la producción de leche de ganado bovino y diseñar un modelo predictivo basado en la información de la cuenca de Lima entre los años 2009 – 2018. Se diseñó un estudio de tipo aplicado, longitudinal, retrospectivo, no experimental y cuantitativo. La variable dependiente promedio total de vacas en ordeño es una variable de tipo cuantitativa, continua y de escala de razón, mientras que la variable independiente meses es una variable de tipo cuantitativa, politómica y de escala nominal. Se utilizaron 120 registros de promedios mensuales de producción de leche de vacas pertenecientes a la cuenca de Lima. Los datos fueron adquiridos del Servicio Oficial de Productividad Lechera, el cual realiza un registro promedio de 6000 vacas mensuales pertenecientes a 20 establos. El análisis estadístico se realizó mediante el paquete estadístico SAS University Edition, con el que se realizó una regresión lineal de serie de tiempo para evaluar el efecto estacional sobre la producción lechera. La elección del modelo estadístico de predicción se realizó teniendo en cuenta el Coeficiente de determinación ajustado (r_(adj.)^2), Akaike Information Criterion (AIC), Bayesian Information Criterion (BIC) y Schwarz's Bayesian Information Criterion (SBC). Los meses del año presentaron un efecto sobre la producción de leche de ganado bovino en la cuenca de Lima. Se observó una disminución de la producción de leche en los meses de verano y primavera mientras que en los meses de otoño e invierno la producción incrementó...
Transmute of Old Home Appliance into Smart Control Home Automation System Using App Inventor Prototype
Authors: D Napoleon , Gopal R.
Published: July 2022

Smart technologies are emerging in the world and imposed a high impact in our day to day life. Yes we are in need of comfort life so we are switching over to the remote control initially with the television and then to fan, air conditioner and heater also. But these smart gadgets which are now in the market are in huge price and not affordable for the middle class people. And moreover we can’t kick out the old appliance which are working properly so this article came up with a solution of not throwing the old appliance and with the minimal changes in the circuit flow and the algorithm based mobile application can able to make the old appliance into smart appliance which can be able to control using the mobile application and also voice control module this application was developed with the MIT app inventor tool which make the interface of front end more user friendly and the powerful backend to make the algorithm more efficient and the small Arduino with Bluetooth component make the appliance to communicate with the mobile application and the single Arduino board can able to control about eighteen or more application depends upon the relay connectors we use. This article has proposed the best and cost efficient conversion method of the home appliance.
Zero-Change Monolithic Integration of CMOS Electronics in Silicon Photonics
Authors: Zanetto Francesco , Toso Fabio , Grimaldi Vittorio , Petrini Matteo , Milanizadeh Maziyar , Perino Alessandro , Morichetti Francesco , Melloni Andrea , Ferrari Giorgio , Sampietro Marco
Published: July 2022

Silicon photonic integrated circuits allow very efficient manipulation of light in a compact size but suffer from strong dependence on temperature variations and fabrication tolerances. Local stabilization of the working point of each photonic device in a circuit is thus needed, made possible by integrated sensors and actuators that are operated by an external electronic controller. However, this approach is what currently limits the scaling of photonic complexity to few tens of devices, due to practical limitations in the number of connections between the chip and the control electronics. Monolithic integration of electronic functionalities into the photonic systems is therefore essential to enable new sophisticated architectures, but it requires to fully preserve the optical quality. Here we demonstrate the possibility of fabricating CMOS integrated electronic circuits on a technological platform specifically conceived and optimized only for photonic devices. By exploiting the silicon waveguide layer and with zero changes to the photonic process flow, fully functional MOS transistors have been integrated on the side walls of the waveguide layer, showing a threshold voltage of 1.84 V, a gain factor of 4 μA/V^2, an Early voltage of 35 V and an inverse subthreshold slope of 250 mV/dec. By combining digital gates and analog switches, we demonstrate the operation of an analog multiplexer integrated into a 16-to-1 optical router to sequentially read 16 on-chip photodetectors with only one connection towards the external electronics. This enables time-multiplexed closed-loop control and stabilization of the router to thermal instabilities with less than 10 ms transient time and a power penalty of just 0.3 dB on the transmission of 10 Gb/s modulated signals. We envision that this first example of co-integrated electronic layer to support the optics and counteract its weaknesses can definitely unleash the full potential of the photonic technology towards a new realm of innovative architectures and applications.
Assessing the Fidelity of the Malaria Vaccine Implementation in Malawi
Authors: Patel Parth K. , Nyondo-Mipando Alinane Linda , Kalanga Noel
Published: July 2022

Globally, remarkable progress has been made in the fight against malaria over the last two decades, yet the rate of reduction of malaria case incidence and mortality seems stalled. Globally, malaria case incidence (i.e., cases per 1000 population at risk) reduced from 80 in 2000 to 58 in 2015 and only to 57 in 2019. Mosquirix (RTS, S/AS01), a four-dose malaria vaccine with an effectiveness of 39%, was piloted by the WHO in three countries including Malawi where it was integrated into the EPI as a regular schedule dose. Fidelity was assessed to evaluate the degree of adherence to the planned protocol for the roll out of the program. This is a qualitative study that used the implementation fidelity framework (2007) where 12 healthcare workers were interviewed, 47 parents attended 2 focused group discussions, and a non-participatory observation checklist determined the status of vaccine storage and administration, in 2 separate health centers serving as immunization clinics. Framework approach analysis was used in this study. 59 participants were interviewed in this study. 12 health workers that were interviewed, 2 (17%) were female and 10 (83%) were male whereas all 47 (100%) parents were female. The average age of HCWs was 38 years while for the parents it was 29 years. The study demonstrated fidelity to the malaria vaccine protocol but to a much lesser extent. It has to some extent been implemented with fidelity and there is demonstrable adherence to the vaccine protocol, nevertheless, numerous gaps still exist.
Incorporating HPV 33 and Cytology into HPV 16 and 18 Screening May Be Feasible. A Cross-Sectional Study
Authors: TATAR BURAK
Published: July 2022

Purpose
The distribution of human papillomavirus (HPV) varies geographically, and each country is making its own screening and vaccination program. This study questioned the need for colposcopy for HPV types other than HPV 16 and 18, and the need for cytology incorporated into HPV testing.
Methods
1043 consecutive patients referred for colposcopy are included in this retrospective study. For statistical analysis, logistic regression analysis, ANOVA and Pearson’s correlation was used. The value of p < 0.05 was considered statistically significant.
Results
HPV 16 was the most common HPV type referred, followed by HPV 18, 52, 51 and 31, respectively. HPV 16 tends to be positive in younger patients than other HPV types (p < 0.05). Only HPV 16 (OR: 1.41, 1.06–1.88 95% CI) and HPV 33 (OR:2.23; 1,06-4.64 95% CI) (p < 0.05) had significant prediction for CIN 2 + lesions. In patients with only a cytological abnormality, cytological abnormality with single other high-risk (hr)HPV (without HPV 16 or 18) or double other hrHPV positivity but without HPV 16 and 18 infections, we detected 159 (19%) CIN 2 + lesions.
Conclusion
HPV 33 may be implemented in hrHPV screening protocols for direct colposcopy referral as well as HPV 16 and HPV 18 in specific regions. If we had been opted HPV-based screening only for HPV 16 and 18 without cytology, 19% of all CIN 2 + lesions would have been missed. HPV based screening only with HPV 16 and 18 may not be feasible. Nonavalent vaccines should be considered for vaccination of specific populations.
Experimental non-alcoholic fatty liver disease causes regional liver functional deficits while total metabolic liver function is preserved
Authors: Eriksen Peter Lykke , Thomsen Karen Louise , Hamilton-Dutoit Stephen , Vilstrup Hendrik , Sørensen Michael
Published: July 2022

Background: Increasing incidence of non-alcoholic fatty liver disease (NAFLD) calls for improved understanding of how the disease affects metabolic liver function.Aims: To investigate in vivo effects of different NAFLD stages on metabolic liver function, quantified by regional and total hepatic galactose elimination capacity in a NAFLD model.Methods: Male Sprague Dawley rats were fed a high-fat, high-cholesterol diet for 1 or 12 weeks, modelling early or late NAFLD, respectively. Each NAFLD group (n=8) had a control group on standard chow (n=8). Metabolic liver function was assessed by 2‐[18F]fluoro‐2‐deoxy‐D-galactose positron emission tomography. Liver tissue was harvested for histology and fat quantification.Results: Early NAFLD had steatosis with 18% fat by liver volume. Late NAFLD had 32% steatosis and showed features of non-alcoholic steatohepatitis (NASH). Regional galactose metabolism was reduced in early NAFLD; more so in late NAFLD, median hepatic standardised uptake values (SUV): 9.8 and 7.4, respectively (p=0.02) and ~12.5 in controls. In early NAFLD, lower SUV was explained by fat infiltration. In late NAFLD, SUV was decreased beyond that attributable to fat; probably related to NASH features. Nonetheless, total capacity for galactose elimination remained intact. In late NAFLD, this was attained by increased fat-free liver mass to 21 g, versus 15 g in early NAFLD and controls (both p≤0.002).Conclusions: Regional metabolic liver function was compromised in NAFLD by replacement of liver tissue with fat and, in late NAFLD, probably by additional structural changes. Total liver function was preserved in late NAFLD by a marked increase in the fat-free liver mass.