bluuebunny/crossref_metadata_2025 huggingface dataset:
Immunohistochemical study of mismatch repair and programmed death ligand-1 protein expression in prostatic acinar adenocarcinoma in correlation with patient clinicopathological parameters
Authors: El-Din Somaia A.S. , Halim Mariam I. , Radwan Nehal A. , Sayed Shaymaa G. , Al Hashmi Khalid , Al Sinawi Shadia , Al-Badi Suaad , Al Rashdi Afrah , Al Husaini Samya , Albadi Hajer , Shalaby Asem A.
Published: August 2024

Background

Castrate-resistant prostate cancer (CRPC) is the main challenge among prostate cancer patients; most are metastatic and eventually resist any treatment. No cure yet exists for them.

Aim

Investigate the immunohistochemical expression of mismatch repair genes (MMR) protein products for loss of expression and programmed death ligand-1 (PDL-1) overexpression in prostatic acinar adenocarcinoma cases as a trial to find benefit from using immune checkpoint inhibitor drugs as a new therapeutic modality, especially in CRPC.

Patients and methods

This study included 166 cases of prostatic acinar adenocarcinoma of different grades and stages along with different responses to therapy including 57% being classified as CRPC. Tissue microarray was applied using mostly three cores from each donor case, resulting in the formation of six new recipient blocks. Immunohistochemical staining for MSH2, MSH6, MLH1, PMS2, and PDL-1 was done. Interpretation of the results, their correlation with all collected clinical and pathological parameters, and statistical analysis of the results were done.

Results

Most of the studied cases showed retained nuclear stain for all MMR genes (MSH2, MSH6, MLH1, PMS2), with total loss of the nuclear stain found in few cases ranging from one (0.7%) case in MLH1 to six (4.2%) cases in MSH2. PDL-1 was expressed in about seven (4.8%) cases. No significant correlation was found between MMR protein loss or PDL-1 expression and the different clinicopathological parameters including CRPC.

Conclusion

The limited cases that showed MMR protein loss or PDL-1 expression may suggest that the immune checkpoint inhibitors are of limited value in CRPC but can be used as the last option after investigations of these markers as still few cases can show these changes. Patchy loss of MMR proteins is suggested to be further investigated by molecular studies.
The Correlation between Tumour Location, Clinicopathological Characteristics and Mismatch Repair Protein (MMR) Status of Colorectal Cancer In Egyptian Patients
Authors: Elgohary Shimaa A , Abdelsalam Shaimaa Mohamed , Khaled Randa Said Taha
Published: August 2024

Background:

Colorectal cancer (CRC) is considered one of the most common cancers worldwide. By the year of 2035, it is predicted that there will be a dramatic rise of colonic and rectal cancers of 60% and 71.5% respectively. It has been reported that microsatellite instability (MSI) is a genetic target in hereditary nonpolyposis colorectal cancer cases however recent studies have shown that it is also implicated in the development of sporadic cases. MSI/MMR mutations can stimulate tumourigenesis by inactivating tumour suppressor genes and cases with high or deficient MMR (dMMR) have shown a better clinical outcome and response to programmed cell death 1 (PD-1) inhibitors in many studies. Furthermore, right and left sided colon cancers have different clinicopathological features and may display a different MMR status.

Aim of the work:

This work aimed to examine immunohistochemical expression of MMR proteins in colorectal tumours of Egyptian patients and their correlation with the age, sex, tumour grade, histological type and TNM stage to implicate possible therapeutic and prognostic potential.

Material and Methods:

This retrospective study was conducted on 409 cases of archived, formalin fixed paraffin embedded tissue blocks and immunohistochemical staining was performed using monoclonal antibodies against (MLH1, PMS2, MSH2 and MSH6).

Results:

MMR protein expression revealed intact expression (MMR-proficient status) in (84.4%) of the cases while (15.6%) of the cases showed lost protein expression. MMR protein loss was seen more frequently in patients with right side colon cancer compared to left side counterparts and this was statistically highly significant (p=0.001*). MLH1/PMS2 loss was the most frequent pattern while MSH2/MSH6 loss was less frequent. Moreover, a statistically significant correlation was demonstrated between loss of MLH1 and PMS2 among right-side tumours, while left-side CRC tumours revealed obvious loss MSH2 and MSH6. In regards to age and gender, a statistically significant correlation was seen regarding loss of MSH2 (p=0.008*) and MSH6 (p=0.002*). In thirty-eight cases, PMS2 was lost and showed a positive correlation regarding grade (p=0.045*). These results have shown the difference in MMR status of right and left sided colorectal cancers and the potential prognostic and therapeutic impact.

Conclusion:

The frequency of mismatch repair deficiency (dMMR) status in this cohort study carried on Egyptians’ CRC cases was 15.6%. It showed varying expression in right sided CRC in comparison to Left sided ones. The different biological factors regarding right and left sided colonic cancers may be used to identify cases who needs screening and further management.
Role of androgen receptor expression in the metastatic potential of colorectal carcinoma
Authors: Foda Abd AlRahman Mohammad , Sakr Hader I. , Sabry Rania M. , Eldehna Wesal M. , Elaziz Ahmed Elnaghi Khaled Abd , Enan Eman T.
Published: August 2024

Background

The prevalence of colorectal cancer (CRC) is widespread and associated with significant morbidity and deaths. In CRC, hormone receptors, such as androgen receptors (AR), are pathologically modified. Additional research is required to understand better its function and predictive and therapeutic value in CRC metastatic potential.

Objective

To assess the AR status in CRC primary tumors and metastatic lymph nodes.

Methods

Tissue microarray and immunohistochemical techniques were applied to 75 CRC cases with lymph node (LN) metastases. We correlate the results with all relevant clinicopathological indicators of prognostic relevance.

Results and conclusion

Out of the 75 cases that were analyzed, 16% of CRC primaries and 12% of LN metastases had nuclear AR that was focally positive. AR expression was significantly correlated with advanced age, conventional non-mucinous histology, lower grade, and arousal on top of adenoma. A deeper invasion was likewise linked to AR expression; however, this association was not statistically significant. AR expression has a positive prognostic influence since the median overall and disease-free survival of cases with positive AR expression in either primary carcinomas or LN metastases were significantly higher than that of cases with negative expression in both primary and LN metastases. We assume that AR expression in CRC has a positive prognostic influence.
Evaluation of the effect of vitamin D on the placenta, kidney, and growth of developing fetuses in preeclamptic mice
Authors: Abd El Rahman Sarah H. , El Shabaka Hamza , El Ansary Mervat , Mohammed Hend A.
Published: August 2024

Background

Preeclampsia (PE) is a complicated syndrome that leads to maternal and fetal morbidity and mortality. PE is defined by the elevation of the mother’s blood pressure (hypertension) and the presence of proteinuria.

Objective

This study aimed to evaluate the effect of vitamin D on 18-day-old mice fetuses in which the PE syndrome was induced in the mother by L-NG-nitro arginine methyl ester (L-NAME).

Materials and methods

The mice grouping was divided as: (a) the control group (group I), (b) the female pregnant mice of the second group intraperitoneally injected with 50 mg/kg/day of L-NAME (group II), (c) the female pregnant mice of the third group were administered orally with 50 IU/kg/day of vitamin D (group III), and (d) the female pregnant mice of the fourth group were intraperitoneally injected with 50 mg/kg/day L-NAME and then orally, with 50 IU/kg/day vitamin D (group IV). All groups were treated daily from 7 to 14 days of gestation.

Results and conclusion

The placenta of mice injected with L-NAME showed different phases of histopathological changes in the basal and labyrinth zone. Meanwhile, the kidney in 18-day-old fetuses maternally injected with L-NAME showed an apparent enlargement in the glomerular area and the presence of hemorrhages among the tubules. However, the 18-day-old fetuses maternally treated with L-NAME and vitamin D (group IV) showed mild injury. This study concluded that induced PE-like symptoms in pregnant mice by L-NAME caused increased fetal growth restriction, impairment of placental histology, and histopathology of the kidneys of fetuses. On the other hand, vitamin D ameliorated the effect of L-NAME and reduced the risk of PE.
Myopic shift in pediatric cataract surgery associated with age and surgical complications
Authors: Menezes Filho Celso , Messias Andre , Silva Paulo Henrique F , Antunes-Foschini Rosalia
Published: August 2024

Purpose:

To investigate predictors for myopic shift after pediatric cataract surgery after at least 3 years follow-up.

Study Design:

Cross-sectional and retrospective study.

Methods:

This study included patients treated for congenital or infantile cataract operated up to 5 years of age between 2010 and 2017. Patients were recruited for ophthalmologic evaluation. Surgical and medical data were acquired in medical charts.

Statistical Analysis:

Univariate and multivariate regressions were performed to look for potential risk factors for myopic shift.

Results:

This study evaluated 81 eyes of 50 patients, with 62 (77%) being bilateral cases, 48 (59%) with intraocular lens implantation, and 37 (74%) patients being strabismic. Age at surgery was 7.7 (3.7–30.5) months and at evaluation was 93.5 (55.1–113.0) months. Total myopic shift was Symbol ‐4.32 ± 3.25 D, significantly greater in patients operated on up to 6 months of life (-5.73 ± 3.14 D). The distant best-corrected visual acuity (BCVA) was 0.6 (0.3–1.0) log of minimum angle of resolution (logMAR). Regarding myopic shift, in univariate analysis, older age at surgery is a protective factor (+0.08 D for each month older, P = 0.001). The presence of strabismus (-2.52 D, P = 0.014), aphakia (-2.45 D, P = 0.006), distant BCVA (-0.15 D per 0.1 logMAR, P = 0.024), and surgical complications (-3.02 D, P = 0.001) are risk factors. In multivariate analysis, older age at surgery (+0.06 D, P = 0.012) and surgical complications (-2.52 D, P = 0.001) remain significant.

Conclusion:

In pediatric cataract surgery, myopic shift is greater when surgery is performed in a younger age and if associated with surgical complications.
Efficacy, safety, and tolerability of lifitegrast 5% eye drops: A randomized, double-blind, active-controlled trial in Indian patients with dry eye disease
Authors: Sharma Namrata , Basu Sayan , Shetty Rohit , Kumar Pramod , Mondal Anindita , Babu P Seshu , Srivastava Richa , Pande Ranjana A , Karat Shubashree , Desai Hemaxi P , Manjula S , Kumar M Krishna
Published: August 2024

Purpose:

To compare the efficacy, safety, and tolerability of lifitegrast 5% versus carboxymethylcellulose (CMC) 0.5% in adult patients with dry eye disease (DED).

Methods:

A total of 370 eligible patients with DED were randomized equally to receive twice-daily doses of a single drop in each eye of either lifitegrast 5% or CMC 0.5% for 12 weeks. Follow-up at weeks 2, 6, and 12 evaluated changes from baseline in primary [eye dryness score (EDS), ocular discomfort score (ODS), ocular surface disease index (OSDI), and tear film break-up time (TFBUT)] and secondary [Schirmer tear test (STT) score and corneal fluorescein staining (CFS) score] endpoints. Global improvement, safety, and tolerability were also assessed.

Results:

At week 2, values of ocular discomfort score, OSDI, and conjunctival redness were significantly more favorable in patients treated with lifitegrast compared to CMC. At week 6, values of all study variables were better in patients treated with lifitegrast compared to CMC; differences between the groups were statistically significant for all except photophobia. This trend was also maintained at week 12. Global improvement and tolerability were found to be better with lifitegrast than with CMC. No serious safety concerns were reported in any treatment group.

Conclusion:

To our knowledge, this is the first active-controlled trial informing on the efficacy, safety, and tolerability of lifitegrast 5%. Significantly more favorable values for EDS (except photophobia), ODS, OSDI, TFBUT, STT score, CFS score, and conjunctival redness score were achieved at week 12 with lifitegrast 5% compared to CMC 0.5%.
To identify risk factors for central visual field progression in moderate to advanced glaucoma
Authors: Patil Trupti S , Natarajan Viswanathan , George Ronnie
Published: August 2024

Purpose:

To identify the risk factors for central visual field progression in moderate to advanced glaucoma.

Methods:

We included patients with moderate to advanced primary glaucoma who had undergone at least five reliable Humphrey visual field (HVF) 10-2 tests with follow-up of at least 2 years. Regression slopes for each threshold location on the 10-2 plot were calculated. A test location with a regression slope worsening more than -1 dB/year with P < 0.01 was labeled as a progressing point on point-wise linear regression (PLR) analysis. We compared point-wise progression with progression on the 10-2 mean deviation (defined as a negative MD slope P < 0.05).

Results:

Ninety-six eyes of 74 patients with a median follow-up of 4 years (±1.97) were included. The median mean deviation 10-2 (MD) at inclusion was -19.01 dB (interquartile range [IQR] -13.2 to -24.14). Eighteen eyes (18.75%) had moderate glaucoma and 78 eyes (81.25%) had advanced glaucoma. The baseline median 24-2 MD in moderate glaucoma was -10.35 dB (IQR -11.35 to -9.25) and in advanced glaucoma was -24.96 dB (IQR -28.48 to -18.26). Based on 10-2 PLR, 27 eyes (28%) showed progression. On multivariate logistics regression analysis, the rate of change for 10-2 MD was a risk factor for progression based on 10-2 PLR analysis: odds ratio (OR) 0.04 (95% confidence interval [CI]: 0.006–0.323), P = 0.002, and for progression based on 10-2 MD analysis: OR 0.03 (95% CI: 0.002–0.602), P = 0.02. In addition, average MD 24-2 (OR 1.343 [95% CI: 1.006–1.793], P = 0.04) and visual field index (OR 0.787 [95% CI: 0.649–0.954], P = 0.01) were found to be risk factors based on 10-2 PLR.

Conclusion:

Rate of change for 10-2 mean deviation and baseline damage were predictors of point-wise progression.
Practice patterns in pediatric myopia management: Insights from a 2023 survey among Indian ophthalmologists
Authors: Kochgaway Lav , Chandra Anuradha , Basu Ipsita , Chaudhury Debarpita , Jethani Jitendra , Bhaumik Arup
Published: August 2024

Objective: This study investigates the practice patterns related to paediatric myopia among Paediatric Ophthalmologists in India, based on a 2023 survey conducted via Google Forms. Methods: The survey aimed to gather insights into physicians' perceptions and experiences concerning the clinical and treatment aspects of myopia in children. Results: The survey reveals several key insights into current practice patterns among Paediatric Ophthalmologists in India regarding paediatric myopia management. The recommended mean age for a child's first eye checkup is 3 years, underscoring the importance of early detection. Refractive error thresholds for prescribing spectacles are set at 3.0 D for infants, 2.0 D for preschool children, and 1.0 D for school-going children older than 3 years. There is a growing trend in using 0.01% Atropine eye drops for myopia management, with a mean prescription age of 4.83 years. Notably, 80.11% of respondents prioritize documenting myopia progression regardless of the child's age. Orthokeratology and Peripheral Defocus spectacle lenses are gaining recognition, and lifestyle modifications such as increasing outdoor activities and reducing near activities are widely acknowledged as effective. While most respondents do not use progressive lenses for myopia, there is significant emphasis on axial length measurements and considering the lag of accommodation. Additionally, under-correction of myopia is favored by a notable proportion of practitioners. These findings indicate a shift towards early intervention and evidence-based strategies in myopia control. Conclusions: The survey highlights a shift towards early intervention and evidence-based myopia control strategies among practitioners. There is, however, room for improvement in standardizing approaches and considering additional factors like axial length and lag of accommodation. Collaborative efforts among policymakers, health regulatory bodies, and industry stakeholders are essential to enhance the accessibility and affordability of myopia control treatments and address the growing health burden associated with paediatric myopia.
Atypical mycobacterial keratitis: Clinical outcome in nonrefractive surgery cases
Authors: Priyadarshini Kshyanaprava , Priyadarshini Smruti Rekha , Sahu Srikant Kumar , Behera Himansu Sekhar , Das Sujata
Published: August 2024

Purpose:

To identify the predisposing factors, clinico-microbiological profiles, and treatment responses in patients with atypical mycobacterial keratitis.

Methods:

The study retrospectively analyzed patients who presented at a tertiary eyecare center in eastern India with atypical mycobacterial keratitis between 2008 and 2021. The diagnostic criteria included cases positive for acid-fast bacilli on Ziehl–Nielsen stain or culture. The antibiotic susceptibility pattern was observed, and treatment was initiated accordingly.

Results:

Out of the 29 cases, ocular predisposing factors were present in 62.1% with an antecedent history of trauma, and vegetative matter was the most common risk factor. There was no predisposing association with systemic conditions in any case. A long lag time was observed between the onset of corneal infection and presentation in 79.3% of cases, with the average time being 43.7 days. Clinical signs mimicked fungal keratitis in most cases. Typical cracked windshield appearance was only observed in two cases. Two patients presented with clinical pictures like peripheral ulcerative keratitis. Topical amikacin was used as treatment in 28 cases. Based on disk diffusion assay, 28 (96.5%) isolates were sensitive to amikacin. Twelve (41.3%) were sensitive to vancomycin, six (20.6%) to gatifloxacin, six (20.6%) to ciprofloxacin, and four (13.7%) to moxifloxacin. Twelve participants showed good final visual acuity posttreatment, which improved to over two lines of Snellen’s visual acuity chart (44.5%).

Conclusion:

Atypical mycobacteria keratitis may not present with classically described clinical features. The duration of presentation, clinical presentation, special microbiological stains, targeted therapy, and antibiotic susceptibility patterns are the key to successfully managing these intractable infections and obtaining favorable outcomes.
Journey of frontalis muscle advancement in severe blepharoptosis: Review of the techniques, modifications, and outcomes
Authors: Bhattacharjee Kasturi , Sawarkar Komal , Soni Deepak , Wavikar Gargi
Published: August 2024

We aimed to review the degree of standardization of frontalis muscle (FM)–orbicularis muscle advancement techniques in the management of severe congenital blepharoptosis and also study the evidence which supports the procedure correcting blepharoptosis. The undisputed rationale of all types of brow suspension in the management of severe blepharoptosis is based on the concept that slings are the conventional way to simultaneously suspend a ptotic eyelid and transmit the contractile action of the FM to the tarsal plate. Traditionally, frontalis suspension using sling has been used to treat patients with severe congenital blepharoptosis with poor levator function; however, postoperative lagophthalmos, forehead scarring, and recurrence remain major concerns. Since the early 80s, a significant number of consecutive articles have suggested that the eyelid can be effectively suspended by directly suturing FM to the tarsal plate. This review article intends to evaluate the level of standardization of FM advancement techniques in the management of severe blepharoptosis. 'In addition, to determine if the procedure should be performed in a standard manner, and is there enough evidence available to recommend FM advancement as a useful surgical technique.
Sugar-Sweetened Beverages and Diet Related Chronic Non-Communicable Diseases in Sub-Saharan Africa
Authors: Amu Hubert , Dotse Priscilla A. N. , Atimbisa Jennifer , Ohipeni Doris K. , Kamal Sarat , Charles-Unadike Veronica O. , Addo Phyllis , Baiden Frank E.
Published: August 2024

abstract

In Sub-Saharan Africa (SSA), diet-related chronic non-communicable diseases (DR-CNCDs) pose a growing public health threat, jeopardising progress towards achieving Sustainable Development Goal 3.4. One contributing factor to this rising threat is the recent surge in consumption of sugar-sweetened beverages (SSBs), across SSA in recent years. Using the socio-ecological model, this commentary explores the nexus between DR-NCDs and SSBs and offers interventions to address this public health challenge at the individual, interpersonal, community, organisational and policy levels. At the individual level, health education campaigns should target individuals and ensure an increase in awareness creation. The life-course approach underscores the importance of promoting healthier dietary choices from childhood to prevent diet-related non-communicable diseases in later life. Schools and workplaces enforcing local policies that discourage SSB consumption patterns will make a huge difference at the community and organisational levels. At the societal/policy level, comprehensive strategies such as sugar taxes, front-of-pack labelling, advertising restrictions and health education programmes are crucial.
A Targeted Clinical Reasoning Remediation Program for Residents and Fellows in Need
Authors: Parsons Andrew S. , Dreicer Jessica J. , Martindale James R. , Young Gregory , Warburton Karen M.
Published: August 2024

Background There is no standardized, widely accepted process for individualized clinical reasoning remediation.

Objective We describe a novel, targeted assessment and coaching process that allows for individualized intervention for residents and fellows struggling with clinical reasoning.

Methods Residents and fellows at the University of Virginia with performance concerns are referred to COACH (Committee on Achieving Competence Through Help) and assessed by a remediation expert. A subset is referred to a clinical reasoning remediation coach who performs an additional assessment and cocreates an individualized remediation plan. Following remediation, residents and fellows are reassessed by their respective programs. We report the frequency of struggle, remediation time invested, and academic outcomes.

Results From 2017 to 2022, 114 residents and fellows referred to COACH met inclusion criteria, of which 38 (33%) had a deficiency in clinical reasoning. Targeted assessment revealed the following microskill deficits: hypothesis generation (16 of 38, 42%); data gathering (6 of 38, 16%); problem representation (7 of 38, 18%); hypothesis refinement (3 of 38, 8%); and management (6 of 38, 16%). Remediation required a mean of nearly 23 hours per trainee. Of the 38 trainees, 33 (87%) are in good standing at the time of writing.

Conclusions Our unique program offers a feasible, targeted approach to clinical reasoning remediation based on our current understanding of the clinical reasoning process. Early hypothesis generation was the most common microskill deficit identified.
Streamlining Communication: “Resident Huddle” on General Medicine Wards at a Veterans Affairs Hospital
Authors: Litwin Liat , McGarry Brian , McGhee Bryn , Kent Kyle , Warner Scott , Hunsaker Shona , Smeraglio Andrea
Published: August 2024

Background Orienting medical trainees to new practice environments is essential. Huddles have been shown to improve communication and safety outcomes. However, their use in orienting trainees to systems processes and changes on inpatient general medicine (GM) wards remains unexplored.

Objective Implement a weekly inpatient huddle between residents and hospital leaders to improve dissemination of information around health system operations.

Methods In 2019, we established “Resident Huddle,” a weekly 20-minute huddle for senior internal medicine residents rotating on GM wards at a US Department of Veterans Affairs Hospital led by the site leads. Resident Huddle content included system updates, rotation updates, process reminders, performance feedback, and systems and patient safety concerns raised by trainees. Reactions to the huddle were assessed via survey. Behavioral change was assessed by rates of complete trainee admission medication reconciliation documentation before and after huddle implementation.

Results Resident Huddle started in October 2019 and continues to this day. Between October 2019 and June 2022, 136 of 205 participants completed surveys (66% response rate). Respondents agreed or strongly agreed that the huddle provided useful information for care delivery (94%, 128 of 136), improved work engagement (73%, 99 of 136), provided feedback on practice patterns (90%, 121 of 135), and that issues they experienced were acknowledged and acted upon (86%, 114 of 133). Retrospective medical record analysis demonstrated improvement in admission medication reconciliation completion rate by trainees from pre-intervention (32%, 19 of 60) to post-intervention (73%, 44 of 60).

Conclusions A weekly huddle between hospital leaders and residents strengthened communication and equipped trainees with operational health systems knowledge to enhance patient care outcomes while fostering a greater sense of engagement with their work environment.
A Study on the Effectiveness of Chunk Teaching Method in English Writing Teaching in China’s Middle Schools
Authors: Shen Yiyang , Shi Wenxuan
Published: August 2024

Anchored in the researchers’ investigation and experience during the internship at a middle school in Nanjing, Jiangsu Province, this dissertation, carried out under the guidance of the theory of chunk teaching method, sorts out the current research results and findings on chunk teaching method, and then analyzes the differences between the chunk teaching method and other traditional writing teaching methods from the perspectives of contents and functions, which draws a conclusion that the utilization of chunk teaching method in China is of great significance to the improvement of middle school students’ abilities in English writing. Before writing this paper, researchers conducted a series of preliminary preparations such as questionnaires, interviews and the same-topic writing tests. With that in mind, this dissertation reveals the chunk teaching method’s capability of more or strengthening middle students’ English writing ability, and thus demonstrates the effectiveness of chunk recitation in English writing teaching in China’s middle schools, which provides reference and critical materials for scholars in this field.
Navigating Transition: Developing an Instructional Coaching Rubric and UDL-Infused Training for Seasoned Reading and Dyslexia Teachers in Online Education
Authors: Rockwell Rena
Published: August 2024

The central focus of this study is the development of an instructional coaching rubric and the delineation of training activities. The research aims to address the nuanced challenges faced by educators during this transformative process. The primary objective is to craft a comprehensive instructional coaching rubric and training regimen seamlessly integrating Universal Design for Learning (UDL) principals. This endeavor unfolds under the mentorship of an instructional coach, unraveling layers of intricate processes, best practices, and emergent patterns characterizing the shift to online teaching. By dissecting these elements, the study endeavors to provide valuable insights into the development of effective coaching strategies tailored to unique demands of online learning environments. As the educational landscape undergoes a digital transformation, understanding the intricacies of this transition becomes paramount. This research contributes not only to the practical knowledge of instructional coaching but also addresses the critical need for adapting teaching methodologies for educators specializing in reading and dyslexia. Through uncovering the dynamics of successful online education, this study aspires to establish a foundation for future endeavors instructional coaching and teaching training. Ultimately, it aims to foster an environment where seasoned educators can thrive amidst the evolving educational landscape, ensuring their continued efficacy and impact in the digital era.
Beyond the Screen: Socio-Virtualization in Online Higher Education
Authors: Fayda-Kinik F. Sehkar
Published: August 2024

This study aims to explore the perception of socio-virtualization among e-learners in online higher education in terms of negativity in communication (NC) and social attention in virtualization (SAV) with the investigation of the relationship between demographic variables, satisfaction with online courses, and use of the internet with their perception of socio-virtualization. A quantitative research design was employed, and the sample of this study consisted of 427 e-learners who were taking online courses at different faculties of different Turkish universities across the country. The results of descriptive analyses indicated that e-learners’ overall perception of socio-virtualization was detected as moderate. While their NC perceptions were identified as high, their SAV perceptions were also found as moderate. Moreover, significant variations in their perceptions of socio-virtualization were observed across different demographic variables such as gender and internet usage habits. This study contributes to the understanding of the socio-virtualization process in online higher education and its implications are beneficial for designing effective virtual learning environments.
Design Thinking Scale Development: Assessing Reliability and Validity
Authors: Ergin Atilla , Diker Coskun Yelkin
Published: August 2024

This study aims to develop a scale to measure the design thinking process and to evaluate the reliability and validity of this scale. It fills this gap by introducing a 36-item scale specifically designed to measure design thinking abilities across the five key stages of the design thinking process: empathize, define, ideate, prototype, and test, to provide an accurate assessment of individual abilities across these stages. Aligned with the well-established design thinking process, the scale comprises five sub-dimensions, each focused on a specific stage. It employs a 5-point Likert-type response format, ensuring nuanced feedback. Rigorous psychometric evaluations confirmed the scale's trustworthiness. Internal consistency within each sub-dimension was exceptional, with Cronbach's alpha coefficients exceeding .80 across all stages. Remarkably, the overall scale achieved an outstanding .95 Cronbach's alpha, signifying unparalleled cohesiveness and reliability. Validity was further established through rigorous statistical analyses. Exploratory component analysis (EFA) accounted for 60% of the variance, confirming the structure and demonstrating strong item-to-factor loadings (ranging from .31 to .74). Confirmatory factor analysis (CFA) provided additional validation, with all fit indices exceeding established benchmarks, solidifying the scale's accuracy and applicability. Beyond these impressive psychometric qualities, the study offers several key advantages. The concise 36-item format ensures efficient administration and analysis, while the five distinct sub-dimensions allow for targeted evaluation of specific strengths and weaknesses within each stage. This detailed feedback holds immense value for researchers, educators, and professionals seeking to cultivate design thinking capabilities in diverse settings. By providing a validated and reliable tool for design thinking assessment, this study empowers a comprehensive understanding of individual strengths and weaknesses across the five critical stages. This, in turn, enables targeted interventions and fosters the development of effective design-thinking skills in various contexts.
A PSA I’m here too: Exploring the Harmful Experiences of Black Students through Critical Narratives
Authors: McClain Jessica , Wellington Dianne
Published: August 2024

The paper illustrates the digital narratives of 219 Black students within the K-12 educational setting of a large West coast state in the United States. The researchers employed the method of storytelling to analyze Instagram posts created by students, which aimed to shed light on the various forms of injustice experienced by Black students. These online contributions effectively revitalized the significance of Black students' narratives and encounters with racism. The authors posit that educational institutions should reconsider their approach to mitigating the negative consequences encountered by Black students within educational environments. The present study serves as a call to action for educators and stakeholders to confront systemic anti-Blackness and create inclusive educational environments that prioritize the well-being and success of all students. Through collective effort and a commitment to antiracist practices, we can work towards a more equitable and just educational system. Addressing objectification and Whiteness requires a comprehensive approach that surpasses individual actions. Educators must acknowledge the ramifications of racially insensitive behavior and its impact on Black students in K-12 environments.
Opinions of Education Faculty Students About Refugees in Turkey
Authors: Namli Altintas Irem , Yuksel Onur , Uzer Cansel
Published: August 2024

Migration has been a constant in human history, presenting various economic, social, and cultural challenges. The integration of immigrants into society, particularly in terms of language and education, plays a crucial role in fostering social harmony. While Turkey has made progress in its integration policies, challenges persist, including socio-cultural and economic disparities among refugees. This study aimed to explore the perspectives of education faculty students on the refugee situation in Turkey, revealing insights into foreign policy, sustainability, territorial integrity, and safety concerns. The study was conducted using the qualitative research design of a case study method. 55 teacher candidates participated voluntarily, and their views on refugees living in Turkey were obtained through focus group interviews. Participants emphasized the need for stable foreign policies and highlighted language education as essential for successful integration. They expressed apprehensions about the potential security risks associated with refugees and advocated for greater societal awareness and proactive measures. Ultimately, addressing the refugee issue requires both policy adjustments and heightened societal sensitivity.
The Effect of Matific Platform on Preschool Students’ Academic Performance in Mathematics
Authors: Abdul Rahman Shafia
Published: August 2024

This research aimed to examine the effect of the Matific platform on preschool students' academic performance in Mathematics in Al Dhafra Region, United Arab Emirates. It also examined the difference between boys’ and girls' academic performance after using the Matific platform during mathematics learning. An experimental research design with pre- and posttest was conducted over a four-week period. A convenient sampling technique was used to select twenty preschool students in an intact group (11 girls and 9 boys). Data was collected through the Achievement Test instrument using pretests and posttests. Descriptive statistics and paired samples t-tests were used to evaluate differences in pretest and posttest scores among individuals and groups, with further analysis conducted to examine differences between boys' and girls' performance. Findings suggest that there is significant effect of using the Matific platform on students' academic performance in Mathematics. However, no statistically significant differences were observed between the performance of boys and girls in utilizing Matific.
ANALSIS KOMPARASI KINERJA KEUANGAN BANK MEGA SYARIAH MENGGUNAKAN METODE RGEC PADA MASA SEBELUM DAN SELAMA PANDEMI COVID-19
Authors: Azizoma Rusman , Maulida Fauzia Nindita
Published: August 2024

The COVID-19 pandemic has had an impact on all industrial sectors in Indonesia, one of which is the sharia banking sector. During the pandemic, banking performance experienced fluctuations in terms of deposits and debt financing; Bank Mega Syariah also experienced fluctuations in financial ratios and deposits, which could have an impact on the bank's financial performance. The purpose of this study is to evaluate Bank Mega Syariah's financial results utilizing the RGEC approach both before and after the COVID-19 epidemic. This study used quantitative research using a descriptive methodology. Data was acquired through the use of documentation methods. Financial ratio analysis utilizing the RGEC method is the data analysis method employed. The findings demonstrate that Bank Mega Syariah's financial performance, as measured by the RGEC technique, was superior to its pre-COVID-19 pandemic financial performance during the pandemic-affected period. This is shown by Bank Mega Syariah's ability to continue turning in a profit despite the COVID-19 pandemic's negative impact on the business environment. This accomplishment is demonstrated by the growth in several key business metrics, which were maintained, including bank profitability, finance distribution, and Third Party Funds.Keywords: Financial Performance; Bank Health Level; RGEC Method
FAKTOR-FAKTOR YANG MEMPENGARUHI KEPUASAN NASABAH BSI MOBILE
Authors: Samiudin Askal
Published: August 2024

This research was conducted with the aim of examining the impact of E-SERVQUAL variables on the level of satisfaction of BSI Mobile users in the Special Region of Yogyakarta Province. The method applied used the E-SERVQUAL model with the addition of responsiveness as a differentiating factor. The population of focus in this study consisted of active BSI Mobile users in 2022, totaling 82,244, while a sample of 200 BSI Mobile users scattered across the Special Region of Yogyakarta Province was selected. The approach used was quantitative descriptive, and the analysis was carried out using the SEM (structural equation model) method with the software SmartPLS 3.0.The research results indicate that reliability, fulfillment, and responsiveness have a significant impact on the level of satisfaction of BSI Mobile users. On the other hand, efficiency and security/privacy do not have a significant impact on the satisfaction of BSI Mobile users. The theoretical implications of this research are an enhancement of our understanding of the factors influencing the satisfaction of BSI Mobile users, especially in the context of Mobile banking services, from an academic perspective. On the practical side, the findings of this research can be considered in formulating BSI Mobile marketing policies.Keywords: E-Servqual; Cotumer Satisfaction; BSI Mobile
Reducing Rates of Blood Culture Contamination in the Emergency Room
Authors:   , Goldberg Erika
Published: August 2024

Practice Problem: In one emergency room (ER) blood cultures (BC) drawn by nurses had a high contamination rate due to lack of collection standards, which lead to poor patient outcomes. PICOT: The PICOT question that guided this project was; In adult emergency room patients where blood cultures are drawn (P), how does implementation of an evidence-based practice method (I), compared to the standard method of obtaining blood cultures (C), affect blood culture contamination rates (O), within ten weeks. (T)? Evidence: Based on multiple sources within the literature; best evidence for lowering blood culture contamination rates (BCC) is done using EBP guidelines for collection of blood cultures, educating staff members, and having the same BC collection materials handy at all stations within the unit. Intervention: Using EBP guidelines for BC collection a standardization of practice form was made and given to the nurses within the unit. The nurses were then educated and checked off by phlebotomists. Pre-made BC collection kits were placed on the unit for use by nurses. Data was tracked weekly over the 10-week period and nurses who had BCCs were re-educated and checked off again prior to their next BC collection. Outcome: Percent change was used as the measure of success of the project, rather than statistical analysis. It was clear to see that during the implementation phase the rate of BCCs had a steady decline from 4.55% to 2.38%. Conclusion: The results shows that the use of an EBP standardization of BC collection helped decrease the overall BCC rate within the specific ED. This allowed for the total BCC rate to fall below the goal of 3% or less, which is clinically significant.
Evaluación de formulaciones de pulpa de bonito (Sarda chiliensis chiliensis) y algas marinas rojas (Chondracanthus chamissoi) en la elaboración de hamburguesas nutritivas
Authors: Méndez-Ancca Sheda , Zapata Rojas José Carlos , Alvarado Ángela Teresa Palacios , Ruiz Choque Mario , Vera Zúñiga Marco Alexis , Quispe Pacho Marco Antonio , Soto Gonzales Hebert Hernán
Published: August 2024

El ritmo acelerado de la vida moderna y los hábitos alimentícios inadecuados conllevan a incrementar la ingesta diaria de comida chatarra, lo que, a largo plazo repercute negativamente en la salud. Por consiguente, es esencial promover la innovación de alternativas de alimentos rápidos, ricos en proteína y altamente digeribles. En ese contexto, con el objetivo de promover una mejora en la nutrición y presentar alternativas de productos de alto valor nutricional en el ámbito de la comida rápida, surgió la propuesta de desarrollar 03 tipos de formulaciones de hamburguesas del pescado bonito (Sarda chiliensis chiliensis) y el alga marina (Chondracanthus chamissoi), en las siguientes proporciones T1= (P 53.23%, A 17.74%), T2= (P 35.49%, A 35.49%), y T3= (P 17.74%, A 53.23%), que luego de procesadas fueron sometidas a un staff de 80 panelistas, quienes tuvieron la responsabilidad de evaluar los atributos de: olor, color, sabor y textura. Los resultados se analizaron con el modelo estadístico ANOVA y la prueba de comparación de Tukey con un nivel de significancia de 0.05, con el fin de determinar diferencias entre los tratamientos. Los hallazgos revelaron la existencia de dos grupos homogéneos T1 y T2 que presentaban similitudes en olor, sabor y textura, a diferencia de T3; sin embargo, se observó una diferencia significativa en el atributo de color entre T1 y T2. En términos generales los resultados indicaron que T1 presentó mejor aceptación a nivel de medias estadísticas y de calificación general del produto como “bueno”. Se realizó la evaluación nutricional del producto T1 que presentó un aporte proteico de 30.60%, carbohidratos 15%, y un aporte energético de (229.65 Kcal / 100gr). Estos resultados sugieren que el produto desarrollado se presenta como una excelente alternativa alimentaria de comida rápida nutritiva, destacando por su elevado valor nutricional en proteínas y carbohidratos en forma de fibra que favorece la fácil digestión.
SNSF Datastory - Open research data: a first look at sharing practices
Authors: Gorin Simon , Jeney Sylvia , Jorstad Anne , Perini Lionel , von Arx Martin
Published: August 2024

Researchers funded by the SNSF are expected to share their datasets in public repositories. A first look shows that many researchers are not regularly reporting their datasets to the SNSF, but most of those provided follow FAIR principles.
Unsterbliche Werte: Über Historizität und Historisierung
Authors: Trüper Henning
Published: August 2024

Eine neue Erschließung des Zusammenhangs von Geschichtlichkeit, Moral und Wert Was soll es bedeuten, dass etwas geschichtlich ist und nicht nur vergangen? Diese nur scheinbar harmlose Frage führt in ein Labyrinth verschiedener Antworten. Hier tut sich eine oft behauptete und ebenso oft bestrittene Beziehung von Geschichtlichkeit und Unsterblichkeit als Leitlinie auf. Im 18. und 19. Jahrhundert entsteht auf eher zufällige Weise eine Ideenkonstellation, in der die Unsterblichkeit der menschlichen Gattung und der einzelnen menschlichen Seele gegeneinander ausgespielt, kombiniert oder auch gemeinsam abgewiesen werden. Erschließbar durch Lektüren geschichtsphilosophischer Beiträge von Leibniz, Nietzsche, Benjamin und anderen, scheint sich für das 20. Jahrhundert zunächst abzuzeichnen, dass die Verschränkung von (Un-)Sterblichkeitsbehauptungen verschwunden ist. Doch tatsächlich hat sie sich vor allem verwandelt und verlagert. Insbesondere zeigt sich im modernen Verständnis von Normen als in die Unsterblichkeit überführten Werten ein unterschwelliger Fortbestand der älteren Konstellation. Die Studie erarbeitet eine neuartige Konzeption von Historizität, Historisierung und deren Zusammenhängen in kulturellen Erscheinungen wie der Totenfürsorge, des Humanitarismus und der Lebensrettung. Damit lassen sich zeitgenössische Welt- und Krisendeutungen bis hin zu derjenigen des Anthropozäns neu erklären.
Kinerja Pegawai, Gaya Kepemimpinan, dan Motivasi: Pengaruhnya terhadap Kepuasan Masyarakat di Desa Serah, Kabupaten Gresik
Authors: Rif'an  , Abid  , Sutinem
Published: August 2024

Tujuan. Penelitian ini bertujuan untuk mengetahui Peran Kinerja Pegawai Dalam Memediasi Kualitas Pelayanan, Gaya Kepemimpinan, Serta Motivasi Terhadap Kepuasan Masyarakat di Desa Serah, Kecamatan Panceng, Kabupaten Gresik.
Material dan Metode. Jenis penelitian ini menggunakan metode deskriptif kuantitatif. Populasi dalam penelitian ini yakni masyarakat di Desa Serah, Kecamatan Panceng, Kabupaten Gresik. Sampel penelitian ini sebanyak 150 masyarakat. Metode yang digunakan untuk menganalisis yaitu SEM dengan alat Smart PLS.
Hasil. Hasil penelitian menyatakan bahwa Pengaruh kualitas pelayanan terhadap kepuasan Masyarakat di Desa Serah , Kecamatan Panceng, Kabupaten Gresik menunjukkan arah positif dan signifikan, Gaya kepemimpinan terhadap kepuasan Masyarakat di Desa Serah, Kecamatan Panceng, Kabupaten Gresik menunjukkan kearah positif namun tidak signifikan, Motivasi terhadap kepuasan Masyarakat di Desa Serah, Kecamatan Panceng, Kabupaten Gresik menunjukkan kearah positif dan signifikan.
Kesimpulan. Penelitian ini menunjukkan pentingnya meningkatkan kualitas pelayanan dan motivasi pegawai sebagai upaya untuk meningkatkan kepuasan masyarakat di Desa Serah, sementara gaya kepemimpinan, meskipun berkontribusi secara positif, tidak sepenuhnya signifikan dalam konteks ini