bluuebunny/crossref_metadata_2025 huggingface dataset:
Analysis and Design of an Airborne-Dangled Monopole-Antenna Symmetric Remote-Sensing Radiation Source for Airport Runway Monitoring
Authors: Tian Qianqian , Fan Haifeng , Chen Jingjie , Zhang Lei
Published: August 2024

Traditional methods for monitoring the foundation settlement of airport runways predominantly employ equipment such as leveling instruments, total stations, layered settlement instruments, magnetic ring settlement instruments, ground-penetrating radar (GPR), and synthetic aperture radar. These methods suffer from low automation levels, are time-consuming, labor-intensive, and can significantly disrupt airport operations. An alternative electromagnetic detection technique, Controlled Source Audio-Frequency Magnetotellurics (CSAMT), offers deep-depth detection capabilities. However, CSAMT faces significant challenges, particularly in generating high signal-to-noise ratio (SNR) signals in the far-field region (FfR). Traditional CSAMT utilizes grounded horizontal dipoles (GHDs), which radiate symmetric beams. Due to the low directivity of GHDs, only a small fraction of the radiated energy is effectively utilized in FfR observations. Enhancing the SNR in FfR typically requires either reducing the transceiving distance or increasing the transmitting power, both of which introduce substantial complications. This paper proposes an airborne-dangled monopole-antenna symmetric remote-sensing radiation source for airport runway monitoring, which replaces the conventional GHD. The analytical, simulation, and experimental verification results indicate that the energy required by the airborne-dangled symmetric source to generate the same electric field amplitude in the FfR is only one-third of that needed by traditional CSAMT. This results in significant energy savings and reduced emissions, underscoring the advantages of the airborne-dangled monopole-antenna symmetric source in enhancing energy efficiency for CSAMT. The theoretical analysis, simulations, and experimental results consistently verify the validity and efficacy of the proposed airborne-dangled monopole-antenna symmetric remote-sensing radiation source in CSAMT. This innovative approach holds substantial promise for airport runway monitoring, offering a more efficient and less intrusive solution compared to traditional methods.
Precise Wigner–Weyl Calculus for the Honeycomb Lattice
Authors: Chobanyan Raphael , Zubkov Mikhail A.
Published: August 2024

In this paper, we propose a precise Wigner–Weyl calculus for the models defined on the honeycomb lattice. We construct two symbols of operators: the B symbol, which is similar to the one introduced by F. Buot, and the W (or, Weyl) symbol. The latter possesses the set of useful properties. These identities allow us to use it in physical applications. In particular, we derive topological expression for the Hall conductivity through the Wigner-transformed Green function. This expression may be used for the description of the systems with artificial honeycomb lattice, when magnetic flux through the lattice cell is of the order of elementary quantum of magnetic flux. It is worth mentioning that, in the present paper, we do not consider the effect of interactions.
Management Economic Systems and Governance to Reduce Potential Risks in Digital Silk Road Investments: Legal Cooperation between Hainan Free Trade Port and Ethiopia
Authors: Wang Shumin , Li Qianyu , Khaskheli Muhammad Bilawal
Published: August 2024

This research explores the interplay between innovation, economic systems, governance structures, and law, and how they interact with one another in the context of China and Ethiopia’s investments in the Digital Silk Road. The way cutting-edge methods related to governance and economic systems might help lower the risks involved in major infrastructure projects, like the Digital Silk Road, particularly in light of law and 5G developments, is investigated. China–Africa connections are to be strengthened, sustainable development is to be encouraged, and healthy economic progress is the goal of the partnership between Ethiopia and the Hainan Free Trade Port. The impact of these transnational investments on fair growth and sustainable development is assessed, while exploring the evolving agendas and procedures governing investments. This research draws attention to how the law and legal cooperation between Ethiopia and China may promote mutually advantageous outcomes, promote transparency and governance mechanisms, and lessen the likelihood of disputes. This research on the factors influencing the future of the Digital Silk Road and its consequences for long-term, sustainable economic growth, and business in the area, aims to provide valuable insights for policymakers, development professionals, and academics, and for the copromotion of China and Ethiopia in terms of digital investment. This research relates to the promotion of the African Continental Free Trade Area (AfCFTA), in terms of construction and economic development. It also examines how the DSR raises concerns about data security and privacy, cross-border transactions, technology transfer, and cyberterrorism, as well as encourages digital investment, such as through enhancing digital governance regulations, modernizing international investment agreements (IIAs), and bolstering global health, coordination, and cooperation; the article concludes by analyzing the implications for Africa. The findings show that such cooperation would support Africa’s digital transformation and sustainable development, while strengthening China–Africa cooperation.
Increasing Security Levels in the Tourism and Air-Transport Industries Could Enhance African People’s Quality of Life and Tourism Demand
Authors: Florido-Benítez Lázaro
Published: August 2024

The aims of this study are to analyze the tourism and air-transport industries in Africa and determine how African governments could improve the safety of tourists and local communities in this region to improve resident quality of life and tourism demand. Indeed, this study tries to improve African people’s lives through the tourism and travel sectors so that they can thrive in terms of their quality of life and happiness. The findings of the current study reveal that Morocco, Egypt, South Africa, and Tunisia are the most visited countries by international tourists; in fact, these four countries are the ones that generated the most income from international tourism in the period analyzed. Moreover, the results suggest that the tourism and air-transport industries in Africa could improve national economies, infrastructure, and resident quality of life thanks to international tourism receipts and increasing security levels around travel and tourism activities. Obviously, the tourism industry cannot be developed when there is constant insecurity, terrorism, and perpetual armed conflicts, as is the case in Nigeria, Somalia, DR Congo, Libya, Mali, and Cameroon, among many others. Security is the most important factor for a tourist destination because the safety and security of residents and tourists are the primary factors affecting tourism growth. The novelty of this research resides in its willingness to improve African people’s quality of life through air-transport and tourism activities, providing security guarantees for tourist and resident safety. This manuscript also contributes to enhancing and bootstrapping the literature on security in the travel and tourism sectors industry, particularly in Africa, where security is a priority more than a necessity.
Perfluoroalkyl and Polyfluoroalkyl Substances in Relation to the Participant-Reported Total Pregnancy and Live Birth Numbers among Reproductive-Aged Women in the United States
Authors: Huang Guangtong , Li Jiehao , Zhou Lixin , Duan Tiantian , Deng Langjing , Yang Pan , Gong Yajie
Published: August 2024

Perfluoroalkyl and polyfluoroalkyl substances (PFASs), widely utilized in various industries, may pose potential reproductive well-being risks. However, the research on the impact of PFAS exposures on pregnancy and live birth rates remains scarce. To address this gap, we conducted a cross-sectional study using the data from the United States National Health and Nutrition Examination Survey (NHANES) collected between 2013 and 2018. We focused on six PFAS compounds measured in the serum of women aged 20 to 50 years, employing the Poisson regression, Quantile G-composition (Qgcomp), and Weighted Quantile Sum (WQS) regression models. Adjusting for age, racial/ethnic origin, educational level, marital status, family income, body mass index (BMI), menarche age, birth control pill use, and other female hormone consumption, the Poisson regression identified significant negative associations between the individual PFAS exposures and pregnancy and live birth numbers (p < 0.05 for all 24 null hypotheses for which the slope of the trend line is zero). The Qgcomp analysis indicated that a one-quartile increase in the mixed PFAS exposures was associated with reductions of 0.09 (95% CI: −0.15, −0.03) in the pregnancy numbers and 0.12 (95% CI: −0.19, −0.05) in the live birth numbers. Similarly, the WQS analysis revealed that a unit increase in the WQS index corresponded to decreases of 0.14 (95% CI: −0.20, −0.07) in the pregnancy numbers and 0.14 (95% CI: −0.21, −0.06) in the live birth numbers. Among the six specific PFAS compounds we studied, perfluorononanoic acid (PFNA) had the most negative association with the pregnancy and live birth numbers. In conclusion, our findings suggest that PFAS exposures are associated with lower pregnancy and live birth numbers among women of reproductive age.
Real-World Observational Analysis of Clinical Characteristics and Treatment Patterns of Patients with Chronic Sialorrhea
Authors: Hast Michael A. , Kong Amanda M. , Abdelhadi Jenna , Shah Rohan , Szendrey Andrew , Holmes Jordan
Published: August 2024

Chronic sialorrhea is a condition characterized by excessive drooling, often associated with neurological and neuromuscular disorders such as Parkinson’s disease, cerebral palsy, and stroke. Despite its prevalence, it remains underdiagnosed and poorly understood, leading to a lack of comprehensive data on patient demographics, clinical characteristics, and treatment patterns. This study aimed to help fill these existing gaps by analyzing real-world data using Optum’s de-identified Clinformatics® Data Mart Database. Patients were required to have a diagnosis indicative of sialorrhea plus evidence of sialorrhea treatment between 1/1/2007 and 5/31/2022. Two cohorts were analyzed: patients with evidence of newly diagnosed sialorrhea and associated treatment, and sialorrhea patients initiating incobotulinumtoxinA. Clinical characteristics, comorbidities, symptoms, and treatment utilization were described before and after diagnosis and incobotulinumtoxinA initiation. No formal statistical comparisons were performed. Patients were predominantly aged 65 or older, male, and non-Hispanic white. Parkinson’s disease and cerebral palsy were the most common comorbidities among adults and children, respectively. Treatment patterns suggest that anticholinergics are more commonly used than botulinum toxin therapy. The findings offer valuable information for improving diagnosis and treatment approaches and suggest a need for further research into treatment effectiveness, safety, and disease burden.
Bartonella Neuroretinitis with Initial Seronegativity and an Absent Macular Star: A Case Report and Literature Review
Authors: Pan Jason Timothy , Yong Dayna Wei Wei , Lin Hazel Anne
Published: August 2024

Cat-scratch disease (CSD) is an infectious disease caused by Bartonella henselae, presenting with fever and lymphadenopathy following contact with felines. The ocular manifestations include neuroretinitis, characterised by optic nerve swelling and a macular star. Case Presentation: We discuss a case of neuroretinitis that presented atypically, without a macular star. There was an initial suspicion of Bartonella, but the serology was negative. Our patient was eventually empirically treated for infective neuroretinitis based on a positive contact history (recently scratched by one of his three pet cats). There was progression to a macular star upon serial dilated fundus examination, and the repeated serology one week after symptom onset showed rising titres, supporting a diagnosis of CSD. Conclusions: A judicious review of systems, repeat assays, serial dilated fundus examination, and early ophthalmic evaluation are useful in cases of suspected neuroretinitis, remaining an important differential in the evaluation of sudden-onset painless vision loss and unilateral disc swelling.
SARS-CoV-2 Modulation of HIV Latency Reversal in a Myeloid Cell Line: Direct and Bystander Effects
Authors: Jarmoluk Patricio , Sviercz Franco Agustín , Cevallos Cintia , Freiberger Rosa Nicole , López Cynthia Alicia , Poli Guido , Delpino M. Victoria , Quarleri Jorge
Published: August 2024

Coronavirus disease 2019 (COVID-19) might impact disease progression in people living with HIV (PLWH), including those on effective combination antiretroviral therapy (cART). These individuals often experience chronic conditions characterized by proviral latency or low-level viral replication in CD4+ memory T cells and tissue macrophages. Pro-inflammatory cytokines, such as TNF-α, IL-1β, IL-6, and IFN-γ, can reactivate provirus expression in both primary cells and cell lines. These cytokines are often elevated in individuals infected with SARS-CoV-2, the virus causing COVID-19. However, it is still unknown whether SARS-CoV-2 can modulate HIV reactivation in infected cells. Here, we report that exposure of the chronically HIV-1-infected myeloid cell line U1 to two different SARS-CoV-2 viral isolates (ancestral and BA.5) reversed its latent state after 24 h. We also observed that SARS-CoV-2 exposure of human primary monocyte-derived macrophages (MDM) initially drove their polarization towards an M1 phenotype, which shifted towards M2 over time. This effect was associated with soluble factors released during the initial M1 polarization phase that reactivated HIV production in U1 cells, like MDM stimulated with the TLR agonist resiquimod. Our study suggests that SARS-CoV-2-induced systemic inflammation and interaction with macrophages could influence proviral HIV-1 latency in myeloid cells in PLWH.
Burden of Congenital CMV Infection: A Narrative Review and Implications for Public Health Interventions
Authors: Liberati Cecilia , Sturniolo Giulia , Brigadoi Giulia , Cavinato Silvia , Visentin Silvia , Cosmi Erich , Donà Daniele , Rampon Osvalda
Published: August 2024

Cytomegalovirus causes the most common congenital infection worldwide. With most infants asymptomatic at birth, the few affected may present with variable clinical scenarios, from isolated hearing loss to severe neurologic impairment. Public health interventions include all actions at the health system, community, and individual levels that aim at reducing the burden of congenital Cytomegalovirus. This review examines the literature on maternal and neonatal screening programs in light of current evidence for treatment and the development of vaccines against Cytomegalovirus. Potential biases and benefits of these interventions are outlined, with the objective of increasing awareness about the problem and providing readers with data and critical tools to participate in this ongoing debate.
Spleen Swabs for Sensitive and High-Throughput Detection of African Swine Fever Virus by Real-Time PCR
Authors: Cafariello Christopher , Goonewardene Kalhari , Chung Chungwon J. , Ambagala Aruna
Published: August 2024

African swine fever (ASF) continues to spread in Africa, Europe, Asia and the island of Hispaniola, increasing the need to develop more streamlined and highly efficient surveillance and diagnostic capabilities. One way to achieve this is by further optimization of already established standard operating procedures to remove bottlenecks for high-throughput screening. Real-time polymerase chain reaction (real-time PCR) is the most sensitive and specific assay available for the early detection of the ASF virus (ASFV) genome, but it requires high-quality nucleic acid extracted from the samples. Whole blood from live pigs and spleen tissue from dead pigs are the preferred samples for real-time PCR. Whole blood can be used as is in nucleic acid extractions, but spleen tissues require an additional homogenization step. In this study, we compared the homogenates and swabs prepared from 52 spleen samples collected from pigs experimentally inoculated with highly and moderately virulent ASF virus strains. The results show that not only are the spleen swabs more sensitive when executed with a low-cell-count nucleic acid extraction procedure followed by real-time PCR assays but they also increase the ability to isolate ASFV from positive spleen samples. Swabbing is a convenient, simpler and less time-consuming alternative to tissue homogenization. Hence, we recommend spleen swabs over tissue homogenates for high-throughput detection of ASFV by real-time PCR.
The Feline calicivirus Leader of the Capsid (LC) Protein Contains a Putative Transmembrane Domain, Binds to the Cytoplasmic Membrane, and Exogenously Permeates Cells
Authors: Peñaflor-Téllez Yoatzin , Escobar-Almazan Jesús Alejandro , Pérez-Ibáñez Carolina , Miguel-Rodríguez Carlos Emilio , Gómez de la Madrid Jaury , Monge-Celestino Erick I. , Talamás-Rohana Patricia , Gutiérrez-Escolano Ana Lorena
Published: August 2024

Feline calicivirus (FCV), an important model for studying the biology of the Caliciviridae family, encodes the leader of the capsid (LC) protein, a viral factor known to induce apoptosis when expressed in a virus-free system. Our research has shown that the FCV LC protein forms disulfide bond-dependent homo-oligomers and exhibits intrinsic toxicity; however, it lacked a polybasic region and a transmembrane domain (TMD); thus, it was initially classified as a non-classical viroporin. The unique nature of the FCV LC protein, with no similarity to other proteins beyond the Vesivirus genus, has posed challenges for bioinformatic analysis reliant on sequence similarity. In this study, we continued characterizing the LC protein using the AlphaFold 2 and the recently released AlphaFold 3 artificial intelligence tools to predict the LC protein tertiary structure. We compared it to other molecular modeling algorithms, such as I-Tasser’s QUARK, offering new insights into its putative TMD. Through exogenous interaction, we found that the recombinant LC protein associates with the CrFK plasmatic membrane and can permeate cell membranes in a disulfide bond-independent manner, suggesting that this interaction might occur through a TMD. Additionally, we examined its potential to activate the intrinsic apoptosis pathway in murine and human ovarian cancer cell lines, overexpressing survivin, an anti-apoptotic protein. All these results enhance our understanding of the LC protein’s mechanism of action and suggest its role as a class-I viroporin.
Role of Protein VII in the Production of Infectious Bovine Adenovirus-3 Virion
Authors: Kulanayake Shermila , Singh Barinder , Dar Faryal , Tikoo Suresh K.
Published: August 2024

Bovine adenovirus (BAdV)-3 genome encodes a 26 kDa core protein designated as protein VII, which localizes to the nucleus/nucleolus. The requirement of a protein VII-complementing cell line for the replication of VII-deleted BAdV-3 suggests that protein VII is required for the production of infectious progeny virions. An analysis of the BAV.VIId+ virus (only phenotypically positive for protein VII) detected no noticeable differences in the expression and incorporation of viral proteins in the virions. Moreover, protein VII does not appear to be essential for the formation of mature BAV.VIId+. However, protein VII appeared to be required for the efficient assembly of mature BAV.VIId- virions. An analysis of the BAV.VIId- virus (genotypically and phenotypically negative for protein VII) in non-complementing cells detected the inefficient release of virions from endosomes, which affected the expression of viral proteins or DNA replication. Moreover, the absence of protein VII altered the proteolytic cleavage of protein VI of BAV.VIId-. Our results suggest that BAdV-3 protein VII appears to be required for efficient production of mature virions. Moreover, the absence of protein VII produces non-infectious BAdV-3 by altering the release of BAdV-3 from endosomes/vesicles.
The Disorderly Nature of Caliciviruses
Authors: Young Vivienne L. , McSweeney Alice M. , Edwards Matthew J. , Ward Vernon K.
Published: August 2024

An intrinsically disordered protein (IDP) or region (IDR) lacks or has little protein structure but still maintains function. This lack of structure creates flexibility and fluidity, allowing multiple protein conformations and potentially transient interactions with more than one partner. Caliciviruses are positive-sense ssRNA viruses, containing a relatively small genome of 7.6–8.6 kb and have a broad host range. Many viral proteins are known to contain IDRs, which benefit smaller viral genomes by expanding the functional proteome through the multifunctional nature of the IDR. The percentage of intrinsically disordered residues within the total proteome for each calicivirus type species can range between 8 and 23%, and IDRs have been experimentally identified in NS1-2, VPg and RdRP proteins. The IDRs within a protein are not well conserved across the genera, and whether this correlates to different activities or increased tolerance to mutations, driving virus adaptation to new selection pressures, is unknown. The function of norovirus NS1-2 has not yet been fully elucidated but includes involvement in host cell tropism, the promotion of viral spread and the suppression of host interferon-λ responses. These functions and the presence of host cell-like linear motifs that interact with host cell caspases and VAPA/B are all found or affected by the disordered region of norovirus NS1-2. The IDRs of calicivirus VPg are involved in viral transcription and translation, RNA binding, nucleotidylylation and cell cycle arrest, and the N-terminal IDR within the human norovirus RdRP could potentially drive liquid–liquid phase separation. This review identifies and summarises the IDRs of proteins within the Caliciviridae family and their importance during viral replication and subsequent host interactions.
Transcriptional Response to Tick-Borne Flavivirus Infection in Neurons, Astrocytes and Microglia In Vivo and In Vitro
Authors: Rosendal Ebba , Lindqvist Richard , Chotiwan Nunya , Henriksson Johan , Överby Anna K.
Published: August 2024

Tick-borne encephalitis virus (TBEV) is a neurotropic member of the genus Orthoflavivirus (former Flavivirus) and is of significant health concern in Europe and Asia. TBEV pathogenesis may occur directly via virus-induced damage to neurons or through immunopathology due to excessive inflammation. While primary cells isolated from the host can be used to study the immune response to TBEV, it is still unclear how well these reflect the immune response elicited in vivo. Here, we compared the transcriptional response to TBEV and the less pathogenic tick-borne flavivirus, Langat virus (LGTV), in primary monocultures of neurons, astrocytes and microglia in vitro, with the transcriptional response in vivo captured by single-nuclei RNA sequencing (snRNA-seq) of a whole mouse cortex. We detected similar transcriptional changes induced by both LGTV and TBEV infection in vitro, with the lower response to LGTV likely resulting from slower viral kinetics. Gene set enrichment analysis showed a stronger transcriptional response in vivo than in vitro for astrocytes and microglia, with a limited overlap mainly dominated by interferon signaling. Together, this adds to our understanding of neurotropic flavivirus pathogenesis and the strengths and limitations of available model systems.
Analysis of Inflammatory and Thyroid Hormone Levels Based on Hepatitis A and B Virus Immunity Status: Age and Sex Stratification
Authors: Yun Hyeokjun , Jeon Jae-Sik , Kim Jae Kyung
Published: August 2024

This study investigated the potential associations between hepatitis virus antibody status and thyroid and inflammatory function. The C-reactive protein (CRP), thyroid-stimulating hormone (TSH), and free thyroxine (FT4) levels were measured in individuals with and without antibodies to the hepatitis A virus (HAV) and hepatitis B virus (HBV). Participants were stratified by age, sex, and HAV/HBV antibody status. Participants with and without antibodies to HAV and HBV had normal CRP, TSH, and FT4 levels. However, notable discrepancies were observed in FT4 levels among participants with HAV antibodies and in CRP and FT4 levels among those with both HAV and HBV antibodies, suggesting potential associations between viral immunity and thyroid function, especially in younger participants. Significant variations in thyroid hormone levels were noted when the sample was stratified by sex and HAV and HBV antibody status, indicating that the association between antibody status and thyroid hormone levels varied by sex. This study underscores the need for further research on the effect of viral immunity on inflammatory parameters and thyroid hormone levels.
Comparative Atlas of SARS-CoV-2 Substitution Mutations: A Focus on Iranian Strains Amidst Global Trends
Authors: Abbasian Mohammad Hadi , Rahimian Karim , Mahmanzar Mohammadamin , Bayat Saleha , Kuehu Donna Lee , Sisakht Mahsa Mollapour , Moradi Bahman , Deng Youping
Published: August 2024

Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a new emerging coronavirus that caused coronavirus disease 2019 (COVID-19). Whole-genome tracking of SARS-CoV-2 enhanced our understanding of the mechanism of the disease, control, and prevention of COVID-19. Methods: we analyzed 3368 SARS-CoV-2 protein sequences from Iran and compared them with 15.6 million global sequences in the GISAID database, using the Wuhan-Hu-1 strain as a reference. Results: Our investigation revealed that NSP12-P323L, ORF9c-G50N, NSP14-I42V, membrane-A63T, Q19E, and NSP3-G489S were found to be the most frequent mutations among Iranian SARS-CoV-2 sequences. Furthermore, it was observed that more than 94% of the SARS-CoV-2 genome, including NSP7, NSP8, NSP9, NSP10, NSP11, and ORF8, had no mutations when compared to the Wuhan-Hu-1 strain. Finally, our data indicated that the ORF3a-T24I, NSP3-G489S, NSP5-P132H, NSP14-I42V, envelope-T9I, nucleocapsid-D3L, membrane-Q19E, and membrane-A63T mutations might be responsible factors for the surge in the SARS-CoV-2 Omicron variant wave in Iran. Conclusions: real-time genomic surveillance is crucial for detecting new SARS-CoV-2 variants, updating diagnostic tools, designing vaccines, and understanding adaptation to new environments.
Use of Moringa Oleifera as a Natural Coagulant in the Reduction of Water Turbidity in Mining Activities
Authors: Zea Cobos Angélica Geovanna , Gutiérrez Jessica , Caballero Pablo
Published: August 2024

Mining is a key industrial activity contributing to the global economy, but it generates large volumes of wastewater with high turbidity due to mineral extraction and processing. In Ecuador, the growth of industrial and artisanal mining has worsened water pollution. Effective wastewater management is essential to mitigate the environmental impacts. Traditionally, chemical coagulants like aluminum sulfate reduce water turbidity, but they have drawbacks such as high costs, chemical waste generation, and adverse health effects. The residual aluminum in drinking water can harm the central nervous system and is linked to diseases like Alzheimer’s and dialysis-related conditions. Given these concerns, evaluating plant species as natural coagulants is crucial. Moringa oleifera, widely found in tropical dry forests, has shown effectiveness in water treatment. This study assesses the efficacy of Moringa oleifera paste as a natural coagulant to reduce turbidity in mining wastewater compared to the efficacy of aluminum sulfate. Coagulation and flocculation tests determined the optimal doses and efficiency of both coagulants. The results indicated that Moringa oleifera achieved an 85% turbidity reduction compared to a 92% reduction with aluminum sulfate. This demonstrates its viability and effectiveness as a sustainable, economical, and safe alternative for water purification, promoting environmentally friendly practices in the mining industry.
Evaluating the Spatiotemporal Distributions of Water Conservation in the Yiluo River Basin under a Changing Environment
Authors: Jia Yufan , Jin Junliang , Wang Yueyang , Guo Xinyi , Du Erhu , Wang Guoqing
Published: August 2024

Water conservation is a crucial indicator that measures the available water resources needed for maintaining regional ecological services and socioeconomic development. The Yiluo River Basin plays an essential role in water conservation in the Yellow River Basin, which is one of the most important river basins with vulnerable ecological conditions and a large population in China. However, previous studies have a limited understanding of the distribution of water conservation in the Yiluo River Basin. To address this knowledge gap, we developed a SWAT model to evaluate water conservation in the Yiluo River Basin with high spatial and temporal details on a monthly scale. From a monthly perspective, water conservation accumulation primarily took place in July (54.6 mm), August (23.5 mm), and September (33.2 mm), which are in the flood season. From 1966 to 2018, we found a significant 47% reduction in basin-wide water conservation, and the reduction was primarily influenced by meteorological conditions and underlying surface dynamics. The results of the temporal correlation analysis identified precipitation as the most significant factor influencing water conservation, while the spatial correlation analysis revealed that potential evapotranspiration, vegetation, and elevation had the highest spatial correlation with water conservation. By combining SWAT outputs on the HRU (hydrological response unit) scale with the spatial distribution of HRUs, the study achieved the visualization of the spatial distribution of water conservation, identifying Luonan County, Luanchuan County, and Luoning County as the key regions that experienced water conservation decline over the past decades. These findings advance our understanding of the distributions of water conservation and their key driving factors in the study area and provide valuable policy implications to support ecological protection and water resource management in the Yellow River Basin.
Lab-Scale Treatment of Anaerobic Co-Digestion Liquor from Kitchen Waste, Human Feces, and Municipal Sludge Using Partial Nitritation-Anammox Process
Authors: Wang Xiaolong , Huang Jialu , Li Dongqian , Liu Chao , Tian Dayong
Published: August 2024

Effective nitrogen removal from anaerobic co-digestion is a major challenge to achieving dual-carbon goals. This study explored the acclimatization process of a lab-scale two-stage partial nitritation and anammox process of a stepwise increase in the percentage of raw anaerobic co-digestion liquor from kitchen waste, human feces, and municipal sludge in a venous industrial park in China, which has not been reported yet. Under limited dissolved oxygen (below 0.5 mg/L) and high ammonia levels (200–1500 mg/L), based on adjusting aeration rates, partial nitritation rapidly started up in 50 days. After acclimatization, partial nitritation still performed efficiently and stably, with the final total nitrogen loading rate (TNLR) of 1.24 ± 0.09 gN/L/d, nitrite accumulation rate of 99 ± 4%, and ratio of eff. nitrite/ammonia of 1.32 ± 0.13. In the anammox process, the final total nitrogen removal efficiency, total nitrogen removal rate, and TNLR reached 94 ± 5%, 1.27 ± 0.03 gN/L/d, and 1.36 ± 0.05 gN/L/d, respectively. Chemical oxygen demand (COD) was also reduced in both reactors, with COD removal rates of 0.7 gCOD/L/d in the partial nitritation and 0.4 gCOD/L/d in the anammox process. Overall, the PNA system demonstrated its feasibility in adapting to high ammonia, salinity, and iron levels, when treating anaerobic co-digestion liquor, particularly regarding resource recovery in venous industrial parks.
Spatial Variation of Asymmetry in Velocity and Sediment Flux along the Artificial Aam Tidal Channel
Authors: Lee Guan-hong , Chang Jongwi , Li Wenjian , Ajama Ojudoo Darius
Published: August 2024

Tidal flats, crucial for biodiversity and ecosystem services, are facing significant alterations due to human activities such as reclamation. In South Korea, over 65% of tidal flats have been reclaimed since the 1970s, resulting in morphological changes and altered sediment transport dynamics. This study investigates sediment transport processes in the artificial Aam tidal channel, created as part of the megacity development project in Incheon, Korea. Using data from Acoustic Doppler Current Profiler and Vector instruments deployed in 2019 and 2021, we analyzed tidal asymmetry, current velocities, shear stress, and suspended sediment concentration. Our results reveal a pronounced tidal asymmetry influencing sediment transport, with ebb-dominant currents near the channel entrance and flood-dominant currents in the interior. We observed significant sediment deposition in the landward section of the channel, driven by tidal mixing asymmetry and rainfall events. These findings highlight the complex interactions between artificial structures and natural sediment dynamics, informing future coastal development and management strategies.
Effective Removal of Cu(II) Ions from Aqueous Solution by Cross-Linked Chitosan-Based Hydrogels
Authors: Al-Harby Nouf F. , Alrasheedi Muneera , Mohammed Ard elshifa M. E. , Soliman Soliman M. A. , Mohamed Nadia A.
Published: August 2024

The elimination of metal ions from industrial waste water is one of the most significant environmental needs. For the first time, two chitosan hydrogels that we had previously synthesized, cross-linked with varying concentrations of trimellitic anhydride isothiocyanate (represented by H1 and H2), were utilized in this investigation to adsorb Cu(II) ions. We found that pH 6, 25 °C, 200 mg L−1 of Cu(II) ions concentration, and 15 mg of hydrogel dosage were the ideal parameters for Cu(II) ion elimination. The kinetics of their adsorption fitted to the pseudo-second-order model with the highest correlation coefficient (R2) values equal to 0.999 and 1.00 for H1 and H2, respectively. The experimental qe values were found when H1 was equal to 97.59 mg g−1 (theoretical value is equal to 98.04 mg g−1) and H2 was equal to 96.20 mg g−1 (theoretical value is equal 99.01 mg g−1). The hydrogels achieved a removal effectiveness of 97.59% and their adsorption isotherms matched the Freundlich model, indicating the multi-layered and homogeneous adsorption nature. The removal of copper ions is significantly driven by the physisorption phenomenon. The hydrogels have a great possibility to be utilized as promising, efficacious, reusable adsorbents for industrial wastewater remediation. Thus, incorporation of a cross-linker, containing binding centers for Cu(II) ions, between chitosan chains is a good way to obtain suitable efficient adsorbents which are good choices for application in the field of metal elimination.
Going with the Flow: How Local Water User Associations Have Shaped Water Resource Management in Chile
Authors: Blanco Elisa , Donoso Guillermo
Published: August 2024

Effective and sustainable water resource management requires flexibility and adaptation to local contexts. Our study analyzes the emergence and evolution of local water self-governing associations, reviewing how their struggles and conflicts, both with the public sector and among locals themselves, have been pivotal to achieving agreements and actions towards sustainable water management. Using an adapted version of the Combined Institutional Analysis and Development (IAD) and social–ecological system (SES) framework, also known as CIS, we conducted a comparative analysis of two distinct Chilean cases. This research highlights the critical role of historical factors alongside institutional support, political landscapes, and financial realities in shaping current water management practices. The findings suggest that when the actors are aligned and actions are taken to support local water user management, more efficient, sustainable, and less conflict-ridden water resource management occurs. Furthermore, this study reveals how the experiences, struggles, and successes of these local user associations have shaped national policies, particularly regarding the development of monitoring mechanisms and the promotion of public–private cooperation in water governance. These efforts have not only fostered more resilient water management systems but have also demonstrated the power of grassroots organizations in shaping broader sustainable policies.
Significant Rise in Sava River Water Temperature in the City of Zagreb Identified across Various Time Scales
Authors: Bonacci Ognjen , Žaknić-Ćatović Ana , Roje-Bonacci Tanja
Published: August 2024

The study analyzed available data series of the Sava River’s water temperature measured at the Zagreb gauging station. Official data from the Croatian Meteorological and Hydrological Service (DHMZ) in Zagreb were utilized. Over the 73 years from 1948 to 2020, there are only 53 years with complete measurement records. Despite this limiting fact, it was considered important to analyze the behavior of the Sava River’s water temperatures in Zagreb over the past 70 years, during which a significant increase in air temperatures has been observed in the region, particularly in the city of Zagreb. Analyses were conducted on the characteristic (minimum, mean, and maximum) water temperatures over timescales of years, months, and days. The relationship between water temperatures (TW) and air temperatures (TA) measured at the Grič Observatory and the flows (Q) of the Sava River in Zagreb were investigated. A trend of rising water temperatures was observed throughout the entire period from 1948 to 2020, with the intensity significantly increasing in the recent period starting from 1988. The trend of rising air temperatures is the primary driver of the increase in the water temperatures of the Sava River in Zagreb. However, the impact of reduced water flow, especially during the warm season, should not be overlooked. This effect is amplified by the observed trend of decreasing minimum flows of the Sava during the warm season, from June to September. As a result, the most significant rise in water temperatures of the Sava River in Zagreb occurs during prolonged low-water summer periods, particularly in July. A strong trend has been observed in the increasing number of days per year with mean daily water temperatures of the Sava River exceeding 20 °C. This higher water temperature occurs increasingly earlier in the year, lasts longer, and ends later, often extending into September.
Design and Application of Experience Management Tools from the Perspective of Customer Perceived Value: A Study on the Electric Vehicle Market
Authors: Xu Yuanyuan , Shan Xinyang , Guo Mingcheng , Gao Weiting , Lin Yin-Shan
Published: August 2024

The electric vehicle (EV) market is expanding rapidly, highlighting the need for enhanced customer perceived value to foster loyalty and competitive differentiation. This study investigates how experience management tools can improve customer experience management in the EV sector with an emphasis on sustainable business practices and environmental sustainability. The research explores existing customer experience management methods, the necessary functions of these tools, and their effectiveness in enhancing management capabilities from the perspective of customer perceived value. A thorough literature review and empirical analysis were conducted to design and evaluate tailored experience management tools. The findings suggest that these tools can enhance customer satisfaction and loyalty by addressing key elements of perceived value, such as price perception, quality perception, and brand image. Additionally, improved customer experience management may encourage sustainable consumer behaviors by making eco-friendly EVs more appealing, supporting environmental sustainability. This research aims to bridge the gap between customer perceived value theory and its practical application in the EV industry. It offers insights for manufacturers and marketers seeking to create more engaging and sustainable customer experiences. The implications extend beyond the EV market, providing a potential framework for various industries to enhance customer perceived value through effective and sustainable experience management.
Perceptions of Antenatal Care among Ghanaian Mothers
Authors: Strong Lynn , Byrd Kourtney , Amissah-Essel Salome , Obeng Cecilia
Published: August 2024

In Ghana, some pregnant women may not seek antenatal care due to the unavailability of such services in their communities, although preventive service can help reduce maternal mortality with high-quality care. This study aimed to understand the antenatal care opinions of Ghanaian mothers who sought antenatal care, the barriers they faced, and their suggestions for improvement in antenatal care in Ghana. This study’s data were collected in the Central and Ashanti regions in Ghana from June 2023 to January 2024. Four hundred and fifty mothers in Ghana who indicated that they had given birth within the last 10 years of the data collection period took part in the study. Our findings revealed that 93.6% of Ghanaian mothers perceived their antenatal care to be of good quality due to proper examinations, friendly provider–patient interactions, reassurance, fair treatment, and proper education, whereas 6.5% of Ghanaian mothers perceived their care to be of poor quality due to long wait times, impersonal interactions, inadequate facility resources, and barriers to communication. For Ghanaian mothers to receive better outcomes for themselves and their children, it is worth improving healthcare facilities, healthcare provider preparedness, local transportation, and addressing financial constraints to go from suboptimal to optimal health services.
Methods for the Assessment of Volume Overload and Congestion in Heart Failure
Authors: Pourafshar Negiin , Daneshmand Arvin , Karimi Ashkan , Wilcox Christopher Stuart
Published: August 2024

Acute decompensated heart failure entails a dysregulation of renal and cardiac function, with fluid volume excess or congestion being a key component. We provide an overview of methods for its assessment in clinical practice. Evaluation of congestion can be achieved using different methods including plasma biomarkers, measurement of blood volume from the volume of distribution of [131I]-human serum albumin, sonographic modalities, implantable devices, invasive measurements of volume status including right heart catheterization, and impedance methods. Integration into clinical practice of accessible, cost-effective, and evidence-based modalities for volume assessment will be pivotal in the management of acute decompensated heart failure.
A Biomimetic Optical Cardiac Fibrosis-on-a-Chip for High-Throughput Anti-Fibrotic Drug Screening
Authors: Shang Yixuan , Xu Dongyu , Sun Lingyu , Zhao Yuanjin , Sun Lingyun
Published: August 2024

Cardiac fibrosis has emerged as the primary cause of morbidity, disability, and even mortality in numerous nations. In light of the advancements in precision medicine strategies, substantial attention has been directed toward the development of a practical and precise drug screening platform customized for individual patients. In this study, we introduce a biomimetic cardiac fibrosis-on-a-chip incorporating structural color hydrogels (SCHs) to enable optical high-throughput drug screening. By cocultivating a substantial proportion of cardiac fibroblasts (CFBs) with cardiomyocytes on the SCH, this biomimetic fibrotic microtissue successfully replicates the structural components and biomechanical properties associated with cardiac fibrosis. More importantly, the structural color shift observed in the SCH can be indicative of cardiac contraction and relaxation, making it a valuable tool for evaluating fibrosis progression. By incorporating such fibrotic microtissue into a microfluidic gradient chip, we develop a biomimetic optical cardiac fibrosis-on-a-chip platform that accurately and efficiently screens potential anti-fibrotic drugs. These characteristics suggest that this microphysiological platform possesses the capability to establish a preclinical framework for screening cardiac drugs, and may even contribute to the advancement of precision medicine.
Educational Game Development RPG (Role-Playing Game) Introduction of Department for Prospective Students Using RPG Maker MV
Authors: Annaba Datin
Published: August 2024

Several studies state that many students have the wrong major and things this causes problems for them. Data obtained through questionnaires (2016) in 40 respondents of students majoring in informatics engineering, as much as 65% admitted that he was in the wrong major and the biggest cause was misperception. All respondents agree if there is a game that can introduce engineering majors informatics to prospective students of informatics engineering. Then from the questionnaire another with 30 respondents, prospective informatics engineering students can be withdrawn The conclusion is that most of them still do not really know the majors. There are educational games that successfully teach users and game genres Indonesian gamers' favorite is the RPG genre. Therefore the researchers made a game RPG education to introduce informatics engineering majors. Game creation using the method of collecting data from literature and questionnaires, while game development using the Ramadan & Widyani GDLC method. The software used in making this game is RPG Maker MV. After the game is over, it is tested on 30 prospective engineering student respondents informatics, the result is 80% of respondents stated their perception about the majors information technology is changing.
Puskesmas Medical Record Information System (Case Study: Gedangan Health Center, Sidoarjo Regency)
Authors: Ramadhan Kasim
Published: August 2024

Puskesmas Gedangan, Sidorajo District, in recording Medical Record and administration of patient visit and data processing to patient still manual, so administrative process takes a little time, either in handling patient, or in case of making report. Medical Record Information System of Gedangan Public Health Center of Sidoarjo Regency, Medical Record Tool, Patient Data, Drug Data, Action Data, Doctor Data, and admin configuration, but the system is not built all the services in Puskesmas Gedangan Sidoarjo District. In this research used the Waterfall method, where the means to analyze the problems that occurred in Gedangan Public Health Center of Sidoarjo Regency and a Medical Record Information system which was immediately implemented in the form of computer based application. The results of research on the application of Medical Record Information System, at Public Health Center of Gedangan Kabuaten Sidoarjo, on the guided performance of the employees, so that the process of health services to the community can be done quickly and avoid the mistakes in making the patient's Medical Record report.