bluuebunny/crossref_metadata_2025 huggingface dataset:
The Educational Implications on the Association of Social Media Use and Mental Well-Being in the Post-Pandemic Period
Authors: Fitriana Mimi , Savitri Setiawati Intan , Ahmad Jasmine , Ali Rizwanah Souket , Lathifah Zahra Khusnul
Published: April 2024

This study investigates the educational implications of the association between social media use and mental well-being in the post-pandemic period. As educational practices increasingly incorporate digital platforms, understanding the impact of students' social media engagement on their mental health is imperative. The role of education in the transformation of information and knowledge within the realm of social media contributes to the significant influences towards individuals’ mental well-being, especially during the COVID-19 pandemic. Education also serves as an instrument of social change to help reduce anxiety of COVID-19 among people. This research, therefore, aimed at investigating the association between social media use and COVID-19 Anxiety and mental well-being among Malaysian adolescents. It focused on the importance of educational implications in the associations among the study variables. Using a convenience sampling technique with a correlational research design, 329 adolescents, 18 to 25 years old, were selected for this study. Social Networking Usage Questionnaire (SNUQ), Coronavirus Anxiety Scale (CAS) and Warwick-Edinburgh Mental Well-being Scale (WEMWBS) were uutilised to measure social media use, anxiety of COVID-19 and mental well-being of the adolescents respectively. Three scales showed high internal consistency with α = .92 for SNUQ, α = .90 for CAS, and α = .94 for WEMWBS. The findings of the study indicated a significant positive association between social media use and COVID-19 anxiety (r = .12, n = 329, p < .05), and a significant positive relationship between social media use and mental well-being (r = .19, n = 329, p < .001). However, results showed an insignificant association between COVID-19 anxiety and mental well-being among adolescents (r = -.051, n = 329, p > .001). The study concluded that the use of social media as a platform for educational transfer and information change abstains from anxiety of COVID-19 and uplifts awareness among Malaysian adolescents on the salient positive influences of it towards their mental health.
Dermoscopic features of telangiectasia macularis multiplex acquisita
Authors: Wang Xiaopo
Published: April 2024

Telangiectasia macularis multiplex acquisita is a rarely described entity, characterized by multiple asymptomatic erythematous and/or brownish macules with telangiectasias, preferably on bilateral upper arms and trunk. We reported a 56-year-old Chinese man with telangiectasia macularis multiplex acquisita. Dermoscopic examination demonstrated an erythematous-brownish background with a striking angioid streak pattern (a central arteriole with superficial radiating small vessels attributed to spider-like eruptions) and linear-irregular branching vessels. We suggest dermoscopic features can be used to improve the accuracy of clinical diagnosis and avoid unnecessary skin biopsies.
Retour d’expérience de deux patients traités par Hémodialyse quotidienne à domicile (HDQ) avec traitement d’eau autonome.
Authors: Mougel Sophie , Deleplace Ludivine , Koper Orlane , Galipaud Géraldine , Jeay Alexandre
Published: April 2024

Résumé

Notre hôpital propose depuis longtemps la Dialyse Péritonéale (DP) pour permettre aux patients de maintenir leur autonomie tout en poursuivant leurs activités quotidiennes. Récemment, nous avons introduit l’hémodialyse à domicile quotidienne (HDQ) avec le système Pureflow® un nouveau système permettant de préparer le dialysat à partir de l’eau courante, facilitant ainsi la gestion du matériel nécessaire. Cette initiative a débuté en octobre 2023 avec la formation de deux patients, qui ont ensuite commencé leur traitement à domicile.

L’impact de ce changement a été évalué par des entretiens basés sur une grille d’évaluation de qualité de vie, recueillant les expériences vécues par les patients. Nous rapportons les témoignages de ces deux premiers patients, Mr J. et Mme S., ont partagé leurs expériences positives, notant une amélioration de leur fatigue, de leur sommeil, et une meilleure intégration dans leur vie familiale et sociale. Mme S. a pu adapter ses séances de dialyse à son emploi du temps familial, tandis que Mr J. a retrouvé une certaine autonomie et a amélioré sa condition physique, malgré quelques défis liés à sa routine de dialyse quotidienne.

Ces témoignages soulignent l’amélioration de la qualité de vie des patients grâce à la dialyse à domicile, notamment en termes de réduction de la fatigue, d’amélioration du sommeil et de diminution de la douleur. La transition vers l’HDQ a été bien acceptée, les patients appréciant la flexibilité et l’adaptation de la dialyse à leur environnement familial. Cette expérience positive encourage notre service à continuer de proposer l’HDQ comme alternative avantageuse pour la gestion de l’insuffisance rénale, mettant en avant l’importance de la qualité de vie dans le choix des techniques de dialyse.
Témoignage d’un patient en hémodialyse longue nocturne à domicile sur cycleur conventionnel.
Authors: Huré Fabrice
Published: April 2024

Dialysé moi-même, je partage ici, à sa demande, le parcours de Laurent, 50 ans, patient dialysé, débutant avec une uropathie malformative congénitale diagnostiquée à l’âge de 2 ans. À 25 ans, il découvre qu’il souffre d’insuffisance rénale chronique (IRC) et commence l’hémodialyse pendant 5 ans.

En 2003, Laurent subit une greffe rénale à Amiens, bénéficiant d’une période de 17 ans sans complications majeures. Cependant, les contraintes des centres de dialyse le conduisent à opter pour l’hémodialyse à domicile. Avec le soutien de sa compagne, il apprend les procédures nécessaires.

Après plus d’un an de dialyse à domicile, Laurent découvre la dialyse longue nocturne (HDLN) via les réseaux sociaux. Après en avoir discuté avec son néphrologue, il tente l’HDLN à domicile, avec des séances de 8 heures trois fois par semaine, s’adaptant à ses horaires de travail et à ceux de sa compagne.

Au printemps 2023, des problèmes liés à la qualité de l’eau le conduisent à passer à un cycleur à bas débit de dialysat. Des complications techniques sur l’osmoseur PureFLow® le font revenir aux poches de dialysat, provoquant fatigue et autres problèmes.

Après des essais infructueux avec un autre matériel, les techniciens réinstallent finalement un traitement d’eau adapté, permettant à Laurent de revenir au générateur conventionnel avec traitement d’eau. Il retrouve rapidement ses avantages antérieurs, soulignant l’importance de l’adaptabilité et de la collaboration entre le patient et l’équipe médicale.

En conclusion, l’HDLN à domicile avec un générateur conventionnel et traitement d’eau est actuellement le mode de traitement le plus adapté à ses besoins, permettant à Laurent de mener une vie quasi normale malgré les complications.
Site-Specific Template Generative Approach for Retrosynthetic Planning
Authors: Shee Yu , Li Haote , Zhang Pengpeng , Nikolic Andrea , Sreekumar Sanil , Buono Frédéric , Song Jinhua , Newhouse Timothy , Batista Victor
Published: April 2024

Retrosynthesis, the strategy of devising laboratory pathways for small molecules by working backwards from the target compound, remains a rate limiting step in multi-step synthesis of complex molecules, particularly in drug discovery. Enhancing retrosynthetic efficacy requires overcoming the vast complexity of chemical space, the limited known interconversions between molecules, and the challenges posed by limited experimental datasets. In this study, we introduce generative machine learning methods for retrosynthetic planning that generate reaction templates. Our approach features three key innovations. First, the models generate complete reactions, known as templates, instead of reactants or synthons. Through this abstraction, novel chemical transforms resembling those in the training dataset can be generated. Second, the approach optionally allows users to select the specific bond or bonds to be changed in the proposed reaction, enabling human interaction to influence the synthetic approach. Third, one of our models, based on the conditional kernel-elastic autoencoder (CKAE) architecture, employs a latent space to measure the similarity between generated and known reactions, providing insights into their chemical viability. Together, these features establish a coherent framework for retrosynthetic planning, as validated by our experimental work. We demonstrate the application of our machine learning methodology to design a synthetic pathway for a simple yet challenging small molecule of pharmaceutical interest. The pathway was experimentally proven viable through a 3-step process, which compares favorably to previous 5-9 step approaches. This improvement demonstrates the utility and robustness of the generative machine learning approaches described herein and highlights their potential to address a broad spectrum of challenges in chemical synthesis.
The Correlation between Students’ Reading Anxiety and Their Reading Ability
Authors: Munir Sirajul , Suzanne Nina , Fitri Hidayatul
Published: April 2024

The objective of this research is to determine whether there is a correlation between students’ reading anxiety and their reading ability. This research is a correlational study. The population of this research were the 66 students of the English Teaching Department at UIN Mahmud Yunus Batusangkar. The sample was chosen by simple random sampling technique using Slovin’s formula. As a result, 55 students were used as a sample. The data were gathered by using questionnaires and reading test. The result of this research indicates that there was a correlation between students’ reading anxiety and their reading ability. It is indicated by the data analysis using the “r” product moment formula. The result shows that the calculated correlation coefficient (rxy) was -0.343 which has a negative sign, which means “rxy” has a negative direction. Next, “rxy” (-0.343) with degree of freedom (df)= N-2 (56-2) = 54. It can be stated that the r-table was 0.254 at the level significant 5%. It can be concluded that Ha was accepted because r-calculated (-0.343) was higher than the value of the r-table (0.254).
Being in the Social World: Cognitive Perspectives and Issues Revisited of Chinese Journalism
Authors: 白 红义 , 万 旭琪
Published: April 2024

面对人与物交织的复杂社会网络,经由“事学”逻辑驱动的中国新闻理论已不再具有解释力,中国新闻学研究面临着结构之困、认知之变与实践之惑,亟需一种全新的视角重新理解发生在新闻中的物质、情感与关系变化。因而,本研究引入唯物主义现象学视角中的“社会世界”理论,确立一个由“情境中的交往实践”“关系形式”与“秩序建构”三重递进维度构成的认知视角。通过审视2023年中国新闻学研究的主要议题,本研究尝试对人文主义取向下数字时代新闻理论、组织宣传实践等研究如何开展作出回应,并提出一种迈向“新闻世界”的观点,这既是理解身处社会世界的新闻,也是通过新闻实践来理解我们所处的社会世界。关键词 中国新闻学;唯物主义现
Nonlinear optics of the thin-film quasiwaveguide amplifier: applications to directional switching in the optical communication systems
Authors: Djotyan Gagik P. , Arutunyan Vilik M. , Bakos Joseph S. , S¨orlei Zsuzsa
Published: April 2024

We examine nonlinear optical effects in the active medium of the thin-film quasiwaveguide amplifier-oscillator with injection of the external signal. The injection locking has been obtained in the case when both the frequency and the direction of propagation of the injected signal differ from those for a free-running thin-film laser which offers a possibility for the frequency and directional switching of the output of the thin-film laser. The effects of four wave mixing and phase conjugation have been discussed in the active medium of the thin-film laser when additional mirrors forming an external resonator have been used.
Preface
Authors: Wierzbicki Andrzej P.
Published: April 2024

Preface
Characterization of SOI fabrication process using gated-diode measurements and TEM studies
Authors: Katcki Jerzy , Ratajczak Jacek , Jakubowski Andrzej , Łukasiak Lidia , Tomaszewski Daniel , Gibki Jan
Published: April 2024

SOI fabrication process was characterized using electrical and TEM methods. The investigated SOI structures included partially and fully depleted capacitors, gated diodes and transistors fabricated on SIMOX substrates. From C-V and I-V measurements of gated diodes, the following parameters of partially depleted structures were determined: doping concentration in both n- and p-type regions, average carrier generation lifetimes in the region under the gate and generation velocity at top and bottom surfaces of the active layer. Structures with short lifetime were studied using a transmission electron microscope. TEM studies indicate that the quality of the active layer in the investigated structures is good. Moreover, these studies were used to verify the thicknesses determined by means of electrical characterization methods.
An impact of frequency on capacitances of partially-depleted SOI MOSFETs
Authors: Łukasiak Lidia , Zare¸ba Agnieszka , Jakubowski Andrzej , Tomaszewski Daniel
Published: April 2024

A non-quasi-static model of partially-depleted SOI MOSFETs is presented. Phenomena, which are particularly responsible for dependence of device admittances on frequency are briefly described. Several C-V characteristics of the SOI MOSFET calculated for a wide range of frequencies, preliminary results of numerical analysis and of measurements and brief analysis of the results are presented. Methods of model improvement are proposed
Optimization of selected parameters of SiGe HBT transistors
Authors: Zare¸ba Agnieszka , Jakubowski Andrzej
Published: April 2024

SiGe-base HBTs with Gaussian doping distribution are modeled including the effect of the drift field and variable Ge concentration in the base on the diffusion coefficient. Two different Ge distributions in the base are considered: a triangular one and a box one the patterned substrates suffered from a high loading effect demanding an accurate calibration.
CVD growth of high speed SiGe HBTs using SiH4
Authors: Radamson Henry H. , Grahn Jan , Landgren Gunnar
Published: April 2024

The growth of high frequency HBT structures using silane-based epitaxy has been studied. The integrity of SiGe layers in the base and the control of the collector profile using As- or P-doping grown at 650 oC have been investigated. The results showed that the growth rate of SiGe layers has a strong effect on the evolution of defect density in the structure. Furthermore, B-doped SiGe layers have a~higher thermal stability compared to undoped layers. The analysis of the collector profiles showed a higher incorporation of P in silane-based epitaxy compared to As. Meanwhile, the growth of As- or P-doped layers on the patterned substrates suffered from a high loading effect demanding an accurate calibration.
Silicon-germanium for ULSI
Authors: Hall Steve , Eccleston Bill
Published: April 2024

The paper describes recent progress for the introduction of silicon-germanium, bipolar and field effect heterostructure transistors into mainstream integrated circuit application. Basic underlying concepts and device architectures which give rise to the desired performance advantages are described together with the latest state-of the-art results for HBT and MOSFET devices. The integration of such devices into viable HBT, BiCMOS and CMOS is reviewed. Other contributions that SiGe can make to enhance the performance of ULSI circuits are mentioned also.
Preface
Authors: Jakubowski Andrzej , Werbowy Aleksander , Lukasiak Lidia
Published: April 2024

Preface
On possibility to extend the operation temperature range of SOI sensors with polysilicon piezoresistors
Authors: Druzhi Anatoly , Lavitska Elena , Maryamova Inna , Kogut Igor , Khoverko Yuri
Published: April 2024

The aim of this work was to study the possibilities of developing mechanical sensors with poly-Si piezoresistors on insulating substrate for operation in different temperature ranges (low, elevated and high temperatures). Laser recrys- tallization is used as a technological tool to adjust the elec- trical and piezoresistive parameters of the polysilicon layer. For this purpose a set of studies including numerical simula- tion and experimental work has been carried out. The main three directions of the studies are considered: problems of thermal stabilization of the pressure sensor performance at elevated and high temperatures; problem of sensor operation at cryogenic temperatures; development of a multifunctional pressure-temperature sensor.
Modelling of CDMA systems
Authors: Gajewski Piotr Z. , Krygier Jaroslaw
Published: April 2024

This paper describes a model of a system with wideband CDMA that is a proposal of user access for future UMTS. This model has been implemented using OPNET tool. The model enables network architecture, radio interface, mobile station motion, call generation, signalling, etc. The examples of simulation results of call and handover blocking probability are also presented in this paper.
Fuzzy logic classifier for radio signals recognition
Authors: Łopatka Jerzy , Pędzisz Maciej
Published: April 2024

This paper presents a new digital modulation recognition algorithm for classifying baseband signals in the presence of additive white Gaussian noise. Elaborated classification technique uses various statistical moments of the signal amplitude, phase and frequency applied to the fuzzy classifier. Classification results are given and it is found that the technique performs well at low SNR. The benefits of this technique are that it is simple to implement, has generalization property and requires no apriori knowledge of the SNR, carrier phase or baud rate of the signal for classification.
From modelling of a CDMA transceiver in indoor environment to an ASIC circuit synthesis
Authors: Bourdel Sylvain , Campo Eric , Melet Patrick , Andrieux Laurent
Published: April 2024

This paper presents the study, design and simulation of a multi-flow radio frequency transceiver based on a direct sequence spread-spectrum with a 2.4 GHz carrier. First, the functional model of differential QPSK modulation for digital transmission, and the different parts making up spread spectrum function (spreader, despreader, tracking and synchronising devices) have been studied, implemented, simulated and validated in noisy multi-users and multi-path environment by using a unified language. The results obtained by taking into account the home automation running constraints have allowed to determine some critical parameter values and so to integrate the digital functions in an ASIC circuit.
Walsh-chirp sequences for wireless applications
Authors: Wysocki Beata Joanna , Wysocki Tadeusz Antoni , Zepernick Hans-Jürgen
Published: April 2024

This paper deals with a new method to design polyphase spreading sequences for DS CDMA wireless applications. The method is based on weighting symbols of the orthogonal Walsh sequences by the complex factors being symbols of baseband chirp sequences. The resulting sequences possess good aperiodic correlation properties, while maintaining the orthogonality. Because of the parametric design, the sequences can be optimized to achieve desired characteristics.
Characteristics of the indoor propagation channel in 1.9 GHz band
Authors: Kurek Krzysztof , Janusek Dariusz , Kosiło Tomasz
Published: April 2024

This paper presents results of propagation measurements carried out in the frequency range 1.8;nbsp;-
The simple analysis method of nonlinear frequency distortions in FMCW radar
Authors: Wojtkiewicz Andrzej , Kulpa Krzysztof S. , Nałęcz Marek , Misiurewicz Jacek
Published: April 2024

The paper presents a simple method for estimating nonlinear frequency distortions of linear frequency modulated (LFM) signals used in FMCW radars. This method, derived from the polynomial model of the nonlinear FM signal phase, is based on finding the maximum of two-dimensional chirp-like transform of the IF video signal. The IF signal is obtained by mixing transmitted FM signal with its delayed copy. Using suggested transform we show that the presented method is able to detect and classify signal distortions.
PHEMT transistor models for accurate CAD of MMIC amplifier
Authors: Nosal Zbigniew
Published: April 2024

Accurate modeling of microwave monolithic integrated circuits (MMICs) is very desirable for the reason of high fabrication costs of GaAs circuits. Designers are trying to achieve the ``first trial success`` to lower costs and accelerate the introduction of new products. Mature and reliable technology and accurate models of circuit components - active devices in particular - are crucial for the achievement of economic goals. The D0AH process from the Philips Microwave Limeil (PML) foundry has proven to provide reliable and repeatable circuits, as our 4 year experience indicates. The models presented here are based on many measurements of individual transistors and complete MMICs[1]. These results may aid other designers to select proper model and to adjust its parameters appropriately. The emphasis has been placed on nonlinear models capable of accurate prediction of intermodulation distortion. The level of the IM products is one of the most important parameters specified for modern telecommunication circuits.
Recognition of narrowband rausing autoregressive models and pattern comparison approach
Authors: Łopatka Jerzy
Published: April 2024

This paper presents an improved spectral recognition method for digitally modulated radio signals. It is based on a signal autoregressive (AR) model. Model poles are used as signal features for neural network based on recognition process. To reduce an influence of the signal noise and distortions introduced by the digital receiver, a nonlinear Z plane transformation is proposed.
Photovaractor performance for optically controlled microwavecircuits
Authors: Malyshev Sergey A. , Andrievski Vatslav F. , Budko Tamara O. , Chao Chen , Chizh Alexander L. , Gushchinskaya Elena V. , Baolin Liu , Romanova Ludmila I. , Zaporozhets Emilia V.
Published: April 2024

The photovaractor for optically controlled microwave circuits was designed and studied. The photovaractor module was fabricated as a planar p-i-n photodiode chip placed in a fibre optic matching receptacles. Study of C-V characteristics in the light illumination mode has shown that capacitance characteristics are strongly dependent on the light illumination power. These variations of the photovaractor diode capacitance are large enough to be used in optically controlled circuits such as oscillators, mixers and switchers.
Lowering the uncertainty in fmeasurement proceduresast noise
Authors: Acciari Gianluca , Giannini Franco , Limiti Ernesto , Saggio Giovanni
Published: April 2024

To completely characterise the noise behaviour of a two port device, four noise parameters Fmin, Rn, Gopt and Bopt must be determined. This paper reports improvements in the uncertainty related to the above parameters, taking into account measurement errors due both to the limited instrument precision and connection repeatability. Results are reported for noise characterisation of 0.3 um delta-doped HEMT devices by Alenia, demonstrating as the common hot-cold measurement procedure can result with an error confidence as low as 0.2% for all the noise parameters.
Microwave harmonic generation in fiber-optical links
Authors: Hilt Attila
Published: April 2024

Optical transmission of microwave (MW) and millimeter-wave (MMW) signals has become an intensive research area in the last decade. There is a growing interest in optical processing of MW signals [1, 2], phased array applications [3] and wireless distribution of broadband data in fiber-fed MMW subscriber access systems [4 - 10]. This paper extends the existing models of MW/MMW optical links that are based on optical intensity [10, 11]. The model is suitable for estimating harmonic levels of the MW modulation signal generated in the optical path. Considering a MW fiber-optic link both the optical transmitter and the receiver are responsible for harmonic generation. Furthermore, the optical fiber itself inserted between the transmitter and receiver induces harmonics due to dispersion. Exact modelling of harmonic generation requires a calculation based on the optical field instead of on a purely intensity basis [12 - 14].
Multistage optical switching networks
Authors: Kaczmarek Sylwester
Published: April 2024

The backbone networks evolution to high-speed DWDM networks generates new problems for switching. This function element must be also based on optical technology. For large capacity this cannot be realized by a single matrix, but by multistage switching networks. In the paper three types of optical matrices have been described: fiber switch FX, wavelength fiber switch WSX and wavelength interchanging fiber switch WIX. Based on these matrices, four switching network constructions were considered. The connection properties of these switching networks were evaluated, determining the electronic equivalent switching network for which these properties are well known.
Influence of organism stimulation with bacterial lipopolysaccharide on the metabolism of the extracellular matrix of the heart of rats under conditions of experimental metabolic syndrome
Authors: Akimov O.Ye. , Mykytenko A.O. , Kostenko V.O.
Published: April 2024

Until recently, the extracellular matrix was considered only a structural component of the organ, which performs exclusively the function of the framework. However, recent studies provide insight into a much broader role of extracellular matrix in metabolic homeostasis, the transmission of intra-organ and tissue signals. Metabolic syndrome and chronic infectious diseases can change the extracellular matrix’s structure in the heart. However, the combined effect of bacterial lipopolysaccharide and metabolic syndrome on extracellular matrix of the heart remains insufficiently elucidated at present. The purpose of this work is to establish the effect of organism stimulation with bacterial lipopolysaccharide on the concentration of different fractions of glycosaminoglycans, the intensity of collagenolysis and the content of sialic acids in the heart of rats under conditions of experimental metabolic syndrome. The study was conducted on 24 sexually mature rats of the “Wistar” line weighing 200-260 g. Animals were divided into 4 groups with 6 animals in each group: control, metabolic syndrome group, lipopolysaccharide injection group and combination of lipopolysaccharide injection and metabolic syndrome group. Metabolic syndrome was modelled by using 20% fructose solution as the only water source. Lipopolysaccharide of S. typhi was administered according to the scheme: the first week, 0.4 μg/kg 3 times intraperitoneally, then once a week 0.4 μg/kg throughout the experiment. Experiment lasted for 60 days. The concentration of glycosaminoglycans, their separate fractions, the content of free L-hydroxyproline and sialic acids was studied in 10% rat heart homogenate. The combined effect of stimulation of the organism with bacterial lipopolysaccharide and metabolic syndrome modeling led to an increase in the total concentration of glycosaminoglycans in the heart of rats by 73.46% compared to the control group. Under these conditions, the concentration of the heparin-heparan fraction of glycosaminoglycans in the heart of rats increased by 188.64% compared to the control group. The content of the keratan-dermatan fraction of glycosaminoglycans increased by 75.34%, and the chondroitin fraction of glycosaminoglycans increased by 17.63%. The concentration of free L-hydroxyproline increased by 167.23%. The content of sialic acids increased by 66.95%. Metabolic syndrome, stimulation of the organism with bacterial lipopolysaccharide and their combination lead to intensification of degradation of the extracellular matrix of the heart of rats due to increased collagenolysis, destruction of proteoglycans and glycoproteins.
Peculiarities of personalized selection of antipsychotic drugs for schizophrenia treatment
Authors: Khaustova O.O. , Asanova A.E. , Dzeruzhynska N.O. , Matiash M.M.
Published: April 2024

Determining the optimal antipsychotic drugs, its effective dose, duration of therapy, form, and route of administration play a key role in the treatment of schizophrenia. In addition, special attention should be paid to the effectiveness of using different forms of antipsychotic drugs, in particular, the orally disintegrating form as exemplified by olanzapine. To study the peculiarities of a personalized approach in the use of antipsychotic drugs to achieve more effective results in treating schizophrenia, a content analysis was conducted using Ukrainian and English-language publications for the past 15 years. The search was conducted using the PubMed and CrossRef databases. An important conclusion is that the optimal therapeutic formula or drug should be selected individually, considering the specific patient's clinical condition. However, the most important factor in achieving successful results is the individually selected form and dose of the antipsychotic drugs. In addition to the patient's mental state, the choice of antipsychotic therapy is influenced by the spectrum of side effects, individual sensitivity to the active substance, pharmacological history, economic factors, etc. This is especially true for patients with insufficient adherence to treatment, which can often arise due to the side effects of drugs. In this case, it is important to correctly select both the active substance and the appropriate route of administration. Personalized selection of antipsychotic drugs also involves dynamic monitoring of changes in the patient's clinical condition, allowing for timely diagnosis of drug side effects, dose adjustments, or changes in the route of administration. These measures help increase patient adherence to treatment and improve their health-related quality of life.
Assessment of the efficiency of treatment of patients with COVID-19 (literature review)
Authors: Moskaliuk V.D. , Balaniuk I.V. , Andrushchak M.O. , Sirota B.V. , Honcharuk L.M. , Chernetska N.V. , Ilika V.V.
Published: April 2024

WHO has recog­nized that COVID-19 is a global pandemic. In the conditions when COVID-19 continues to spread rapidly throughout the world, covering different groups of the population, and despite the fact that the existing standards of care for these patients are constantly updated, it is urgent to continue the search for new, more effective methods of treatment. Currently, the treatment of patients with COVID-19 remains difficult, since the drugs that have a harmful effect on the virus are at the stage of development and testing. Remdesivir, favipiravir, hydroxychloroquine with or without azithromycin, ivermectin, lopinavir/ritonavir were recommended among the agents for etiotropic therapy. But at present, the WHO notes that there is no evidence to recommend any specific antiviral treatment against COVID-19. The results obtained by conducting multicenter randomized clinical trials, which were conducted in 30 countries of the world and included 11,266 people of different ages, mostly adults and elderly. Unfortunately, the use of plasma from the blood of people who have contracted COVID-19 does not save the lives of seriously ill patients from the need to be connected to a ventilator and does not increase their chances of survival. This is also reported by WHO. In treatment, emphasis is placed on the application of pathogenetic therapy. The main measures of non-specific individual and collective prevention with the introduction of quarantine are briefly given. The article is intended mainly for doctors who work with patients with COVID-19 and contact persons. Treatment of patients with COVID-19, as a rule, is pathogenetic, since there are no specific antiviral drugs.. The decision regarding medical care in an outpatient clinic setting is made after a clinical assessment of the patient's condition and an assessment of home security. People who are at risk of developing complications should be referred for inpatient treatment.
A model for predicting birth defects of the fetus based on risk factors in mothers with a history of premature birth
Authors: Mammadzada G.
Published: April 2024

Birth defects (BD) are an important cause of neonatal mortality and can be associated with premature birth. The study aimed to develop a prognostic model for congenital malformations in mothers with a history of preterm delivery, using logistic regression analysis. The study included 665 mothers of children with BD, of which 432 (65%) had a history of preterm delivery (main group), and 233 (35%) had term delivery (control group). Variables examined included pregnancy history, genetic factors, and biochemical markers. Statistical analysis found significant associations between BD and preterm delivery, intrauterine malformations, miscarriages, MTHFR polymorphism, and HLA antigens. The logistic model showed good predictive performance. The area under the ROC curve was 0.769 for pregnancy history, 0.699 for miscarriages, and 0.630 for intrauterine malformations, indicating moderate predictive ability. A statistical relationship was found between BD risk and pregnancy history, intrauterine malformations, miscarriages, and genetic factors. The resulting logistic model may help predict BD risk in mothers with a preterm delivery history.
Socio-demographic characteristics of patients with negative and positive symptoms in schizophrenia
Authors:  Kushnir Yu.A.
Published: April 2024

Schizophrenia is a severe mental disorder that leads to impaired social adaptation, interpersonal interaction, and disability. Negative symptoms are an integral part of schizophrenia. In the world psychiatric science and practice, there are still many questions about the typology of schizophrenia, the description of its clinical manifestations, first of all, the features of negative symptoms in schizophrenia. Psychiatrists of different countries draw attention to the fact that these descriptions do not always coincide. Socio-demographic factors can be considered as factors affecting the prognosis of the course and outcome of schizophrenia. In this regard, a comprehensive approach to the study of socio-demographic characteristics of patients with schizophrenia involves the study of the influence of social factors on the formation and course of schizophrenia and determines the relevance of this study. The purpose of the study was to determine the features of socio-demographic characteristics of patients with schizophrenia in order to improve diagnosis and create psycho-corrective measures. 252 patients with negative symptoms of schizophrenia and 79 patients with positive symptoms of schizophrenia were examined. During the research, a comprehensive approach was used, consisting  in the use of clinical-psychopathological, clinical-anamnestic and statistical research methods. Socio-demographic features of patients with negative symptoms in schizophrenia were established, consisting in the predominance of women; patients aged 20-29 years; persons with special secondary education; divorced and single persons; patients busy with physical labor; average level of material wealth; very poor and poor living conditions. Socio-demographic characteristics of patients with positive symptoms in schizophrenia were outlined by the predominance of men; patients aged 30-49 years; persons with incomplete higher education and with higher education; divorced and single persons; patients with disabilities; with extremely low and low levels of material well-being and a satisfactory level of living conditions. The conducted research made it possible to draw conclusions that socio-demographic features of patients with negative and positive symptoms have their own specificity, which should be taken into account when diagnosing patients with schizophrenia.
Biofilm and clinical data between volunteers with self-ligating and conventional brackets: an observational study
Authors: Gonçalves Caroline Gabriela , Galdino Laura Lopes , Gomes Marcelo Sousa , Geraldo-Martins Vinicius Rangel , Cunha Maria Alice Nassif Rodrigues da , Nogueira Ruchele
Published: April 2024

Introduction:  Fixed orthodontic appliances can lead to enamel demineralization and gingival changes due to increased biofilm. Aim: To detect the presence of Prevotella intermedia, Tannerella forsythia, Streptococcus mutans, Scardovia wiggsiae, Aggregatibacter actinomycetemcomitans, Fusobacterium nucleatum, and Porphyromonas gingivalis in oral biofilm and presence of white spot lesions and gingivitis in users of self-ligating and conventional brackets. Design: This observational controlled study was conducted from January to December 2020. The participants used fixed orthodontic therapy for 6 months and were divided into a conventional and a self-ligating bracket group. The participants underwent clinical examination, and biofilm samples were collected from their lower incisors. Results: No differences were found in the bacteria detection between the groups (p>0.05). However, white spot lesions were more common in users of self-ligating brackets (p=0.019). There was no association between clinical data and the detection of any microorganism (p>0.05). The fluorescence intensity of A. actinomycetemcomitans was higher in self ligating brackets than in conventional brackets (p<0.05). Implications: The microbial diversit did not differ between the types of brackets; however, the presence of white spot lesions and the amount of A. actinomycetemcomitans were higher in patients with self-ligating brackets.
Sistem Pemantauan Tempat Sampah menggunakan Pemodelan Edge Computing
Authors: ROKOIYE SITI , RISTIAN URAY , KASLIONO KASLIONO
Published: April 2024

ABSTRAKIoT adalah teknologi yang memanfaatkan konektivitas internet untuk menghubungkan perangkat dan bertukar data. Contoh penerapannya adalah pada sistem pemantauan tempat sampah yang melakukan pemantauan kapasitas sampah dari jarak jauh melalui koneksi internet. IoT memiliki tantangan seperti keterlambatan respons data dan ketergantungan pada internet. Oleh karena itu, untuk mengatasi masalah tersebut, dalam penelitian ini diterapkan pemodelan edge computing dengan memanfaatkan edge server. Penggunaan edge server pada sistem dapat memproses dan mengirimkan data dari berbagai tempat sampah. Ketergantungan pada koneksi internet saat melakukan pemrosesan data dari perangkat IoT dapat dikurangi karena edge server melakukan pemrosesan data secara lokal. Pemrosesan dan pengiriman data menggunakan protokol HTTP. Hasil pengujian QoS yang dilakukan dalam penerapan model edge computing pada sistem pemantauan tempat sampah diperoleh nilai rata-rata throughput 1338 bps dan rata-rata delay adalah 115 ms.Kata kunci: Internet Of Things, Pemantauan Tempat Sampah, Edge Computing ABSTRACTIoT is a technology that utilizes internet connectivity to connect devices and exchange data. An example of its application is in a trash bin monitoring system that remotely monitors trash capacity through an internet connection. IoT has challenges such as data response delays and dependence on the internet. Therefore, to overcome these problems, this research applies edge computing modeling by utilizing edge servers. The use of edge servers in the system can process and transmit data from various bins. Dependence on the internet connection when processing data from IoT devices can be reduced because the edge server performs data processing locally. Processing and sending data using the HTTP protocol. The results of QoS testing carried out in the application of the edge computing model in the bin monitoring system obtained an average throughput value of 1338 bps and the average delay is 115 ms.Keywords: Internet of Things, Trash Bin, Edge Computing
Battery Management System dengan Fitur Adaptive Current Protection terhadap Suhu
Authors: SUHARININGSIH SUHARININGSIH , YULIANDA FRIKO , SUNARNO EPYK , NUGROHO MOCHAMAD ARI BAGUS
Published: April 2024

ABSTRAKKetika charging, baterai lithium-ion seringkali terjadi overheat dan overcharge. Begitu pun ketika discharging juga terjadi overdischarge, overheat dan overcurrent apabila tidak sesuai kurva karakteristik (T=-8.75*I+60). Hal tersebut menyebabkan kerusakan sel baterai sehingga megurangi lifetime baterai. Penelitian ini dibuat sistem battery management system (BMS) yang memantau suhu dan arus melalui pembacaan sensor. Apabila suhu saat charging melebihi batas maksimum (45°C), sistem akan diproteksi dengan menonaktifkan MOSFET (switch). Proteksi ketika discharging terjadi jika suhu atau arus melebihi batas kurva atau safety factor (p). Dari hasil data charging, sistem mampu memproteksi overheat dengan error 0.43% dan menghitung nilai state of charge (SoC) dimana akan beralih ke mode discharge jika melebihi 85% dengan error 0.01%. Saat discharging sistem mampu memproteksi ketika besaran suhu dan atau arus melebihi safety factor yakni 60 dengan error 1.74% serta mampu beralih ke mode charge jika SoC kurang dari 40% dengan errror 0.018%.Kata kunci: Safety factor, Battery Management System, State of Charge ABSTRACTDuring charging, lithium-ion batteries risk overheating and overcharging, while discharging may lead to overdischarge, overheating, and overcurrent if deviating from the characteristic curve (T=-8.75*I+60), causing battery cell damage and reducing lifetime. This study introduces a Battery Management System (BMS) that monitors temperature and current using sensors. If the charging temperature surpasses the limit (45°C), the system protects by deactivating the MOSFET switch. Discharging protection triggers if temperature or current exceeds the curve or safety factor (p). Analyzing charging data, the system defends against overheating with a 0.43% error, calculates State of Charge (SoC), shifting to discharge mode if exceeding 85% with a 0.01% error. During discharging, the system safeguards against temperature and/or current surpassing the safety factor of 60 with a 1.74% error and switches to charge mode if SoC falls below 40% with a 0.18% error.Keywords: Safety factor, Battery Management System, State of Charge
Strategi Operasi Load Shedding dan Islanding Stiffness Sistem Tenaga Listrik pada Kondisi Edge Emergency
Authors: ABDURROHIM MOHAMMAD SALMAN , SUYONO HADI , HASANAH RINI NUR
Published: April 2024

ABSTRAKPenelitian ini mengeksplorasi elemen-elemen krusial dalam menjaga stabilitas sistem tenaga pada kondisi edge emergency, yang terkait erat dengan penjagaan keseimbangan dan pemulihan frekuensi yang cepat setelah terjadinya gangguan. Pengelolaan pasokan listrik dan mempertahankan integritas sistem tenaga listrik, serta strategi load shedding dan operasi islanding, menjadi salah satu upaya untuk menjaga stabilitas. Respons cadangan berputar pada operasi islanding, terutama dalam menyesuaikan daya aktif selama gangguan, memiliki peran krusial untuk menjaga respon kestabilan sesuai batasan edge maksimum dan minimum. Pemodelan mekanisme skema load shedding dan operasi islanding dengan trigger dari stiffness kondisi edge maksimum tercapai dengan menjaga nilai overfrequency dibawah 51,5 Hz dengan nilai frekuensi tertinggi sebesar 51,473 HZ , sedangkan edge minimum tercapai dengan menjaga nilai underfrequency diatas 47,5 Hz dengan nilai frekuensi terendah sebesar 47,517 Hz.Kata kunci: load shedding, islanding, stiffness, edge maksimum, edge minimum ABSTRACTThis study explores crucial elements in maintaining power systems stability during edge emergency condition, closely related to maintaining balance and rapid frequency recovery after disturbances. Efforts aimed at ensuring stability include managing electrical supply, preserving power system integrity, as well as implementing load shedding and islanding operations. Spinning reserve response in islanding operation, particularly in adjusting active power during disturbances, plays a crucial role in maintaining stability responses within specified maximum and minimum edge constraints. Modeling of load shedding schemes and islanding operations triggered by the stiffness conditions of maximum edge condition is achieved by maintaining the overfrequency value below 51.5 Hz, with the highest frequency value being 51.473 Hz. Meanwhile, the minimum edge condition is achieved by maintaining the underfrequency value above 47.5 Hz, with the lowest frequency value being 47.517 Hz.Keywords: load shedding, islanding, stiffness, maksimum edge, minimum edge
k-ZUMKELLER LABELING OF CERTAIN GRAPHS
Authors: Mishra Arijit
Published: April 2024

Let G be any graph. Then a one-one function f:V→ N is said to be a k-Zumkeller labeling of G if the induced function f^*: E→N defined by f^* (xy) =f(x)f(y) satisfies the following conditions: (i) For every xy∈E, f^* (xy) is a Zumkeller number. (ii) |f^* (E)|=k, where |f^* (E)| denotes the number of distinct Zumkeller numbers on the edges of G. In this paper, we prove the existence of k-Zumkeller labeling for certain graphs like tadpole, banana, friendship, and firecracker graphs.
ANALISA PERBANDINGAN ALGORITMA RANDOM FOREST DAN NAÏVE BAYES UNTUK KLASIFIKASI CURAH HUJAN BERDASARKAN IKLIM DI INDONESIA
Authors: Prakoso Indaryono Nicolaus Advendea
Published: April 2024

Indonesia merupakan wilayah yang hampir seluruhnya memiliki iklim tropis. Sebagai daerah yang kebanyakan memiliki iklim tropis, Indonesia mengalami variasi suhu yang sempit namun variasi curah hujan yang beragam. Curah hujan di Indonesia memiliki tingkat keberagaman yang signifikan. Untuk mencegah bahaya yang ditimbulkan oleh curah hujan tinggi, seperti banjir dan tanah longsor. Selain persiapan terhadap bencana, informasi mengenai curah hujan juga bermanfaat dalam bidang pertanian, transportasi, dan industri. Dengan implementasi klasifikasi data mining, akan membantu proses prediksi curah hujan di Indonesia. Penelitian ini menggunakan data iklim harian di Indonesia dan mengadopsi algoritma Random forest sebagai metode klasifikasi. Algoritma tersebut dipilih karena dapat menghasilkan model klasifikasi yang akurat dan stabil tanpa memerlukan penyesuaian parameter yang kompleks. Selain itu, metode Naïve bayes juga digunakan karena kemudahan implementasinya dan pemodelan probabilitas sederhana yang dapat diterapkan pada berbagai jenis data klasifikasi. Berdasarkan hasil penelitian, mendapatkan kesimpulan bahwa algoritma Random forest mendapatkan performa dan akurasi yang lebih baik daripada algoritma Naïve bayes dalam proses klasifikasi dataset iklim di Indonesia. Algoritma Random forest mencapai akurasi sebesar 86.55%, sementara algoritma Naïve bayes hanya mencapai akurasi sebesar 36.61%. Diharapkan hasil dari penelitian ini dapat digunakan sebagai referensi untuk studi literatur penelitian selanjutnya dan digunakan untuk memantau curah hujan harian di Indonesia guna mencegah bencana alam.
Relation-intersectional Ethics Trestle: A Harmonious Merging of Relational Ethics and Intersectionality
Authors: Ko Cindy
Published: April 2024

This article endeavors to merge relational ethics with the theory of intersectionality to create a harmonious platform that could support understanding and applications of their essential concepts in today's diverse and complex health care environments. The key tenets of both frameworks are provided followed by an explanation of a coalesced conceptualization and illustration of a relation-intersectional ethics trestle for consideration of its adaptability in the health care workplace and post-secondary education curriculum.
The main objective is to explain and promote the benefits of integrating the chief precepts of relational ethics and the theory of intersectionality to further strengthen the way health care providers support patients in ethical decision-making. The relation-intersectional ethics trestle aims to support the construction of authentic and mutually respectful therapeutic relationships in clinical settings where ethics and intersectionality unite.