bluuebunny/crossref_metadata_2025 huggingface dataset:
Healthcare Workers and Antineoplastic Drugs: Identifying the Determinants of Exposure and Current Challenges to Reducing Exposure
Authors: Teschke Kay , Chu Winnie , Astrakianakis George , Hon Chun-Yip , Chua Prescillia , Ensom Robin
Published: August 2023

This research aimed to identify the possible determinants of antineoplastic (anti-cancer) drug exposure, in order to develop an evidence-based approach to minimize the exposure risk. The researchers explored which factors are potential barriers to compliance with safe work procedures in order to facilitate changes in practices/attitudes

This study was aimed at better understanding the effectiveness of cleaning protocols in work environments where antineoplastic (anti-cancer) drugs are handled and prepared. A variety of health care workers, besides pharmacy personnel and drug administering nurses, are at risk of occupational exposure to antineoplastic drugs, which can have carcinogenic effects on healthy cells. The researchers calculated a risk estimate based on average contamination levels measured in research participants’ urine, and discovered that there was a slight increase in risk of cancer for health care workers who had absorbed the antineoplastic drug cyclophosphamide (CP), the drug used as the marker in this study

Based on these results, the researchers suggest that current protocols for eliminating surface contamination are not as effective as intended, and make recommendations for improving control and handling procedures to minimize worker exposure to these substances
Development of Analytical Tools To Investigate Aerosolized Cytotoxic Drugs
Authors: Danyluk Quinn , Hon Chun-Yip , Astrakianakis George , Griffiths Andrea
Published: August 2023

This research was aimed at developing and validating an efficient air sampling technique in a controlled laboratory environment, making it possible to accurately assess even low levels of workers’ exposure to cytotoxic drugs. The goal was to allow for the establishment of more effective protocols to better control and manage hazardous drug contaminants within B.C. healthcare facilities.

Cytotoxic (cell killing) drugs, which are used in treating cancer and other illnesses, can be present in the air and on surfaces within health care facilities. In order to study airborne exposures to cytotoxic drugs, accurate sampling methodologies need to be developed.

As a first step, this project designed and built a device for releasing precise quantities of vapour, dried particle or liquid cytotoxic drug aerosols into a sealed chamber for analysis. The project also tested methods of extracting particles of the drug cyclophosphamide (CP) from the chamber for analysis

The researchers’ longer term goal is to develop a personal aerosol sampler that will measure airborne cytotoxic drug particles in health care settings.
Differences In Effectiveness Between Breast Massage And Combination Massage In Breast Milk Production In Postpartum
Authors: Egam Adriana , Nora Veronica Yustitio
Published: August 2023

The lack of exclusive breastfeeding in Indonesia, which is relatively low, could happen because various factors, in particular, influence the lack of care for breasts with method massage. However, until now, a study has not yet been conducted about the eligibility and acceptance of massage with Massage combination relation in increasing the volume of breast milk in postpartum mothers in the district Sorong. Research design is a quasi-experiment with two groups post-test design approach. Subject research is postpartum mothers who have babies 0 months old method taking sample study using accidental sampling. Data analysis in a study this T-test was performed. Obtained value (Sig. (2-tailed)) = 0.00, where in group massage combination capable increase the volume of breast milk by an average score of 75.30 compared with massage breast with an average volume of breast milk of 33.65. it means there is a difference Between massage breasts with massage combination in increasing the volume of breast milk.
The Levels of Authentic Happiness Among Women Who Married at A Young Age at Kaliwungu Village, Ngunut Sub-District, Tulungagung District
Authors: Sal Shabila Ayumas Puteri
Published: August 2023

Early to late adolescents (aged 12-21) experience diverse and fluctuating psychological, mental, mind, and physical dynamics. Living in a household is also not easy and faces many problems. Thus, getting married at a young age potentially influences authentic happiness among women. This paper describes the levels of authentic happiness among women who married at a young age. This research used a quantitative method and literature studies. The population was women who married at a young age in Kaliwungu Village, Ngunut Sub-District, Tulungagung District. There were ten respondents. Data collection was by distributing authentic happiness questionnaires to respondents. The questionnaire consists of 25 statements from the instrument Authentic Happiness Inventory owned by Martin Seligman. Results showed that the score of authentic happiness in all respondents ranges from 75 to 125. In addition, two respondents have moderate levels of authentic happiness, and eight have high. In conclusion, most women who married at a young age had high levels of authentic happiness, and little had moderate.
Analysis of PPE Use with Occupational Disease Risk Control: Analytical Study of Ppe Use at The Sudiang Raya Public Health Center, Biringkanaya District, Makassar City
Authors: Harlina  , Alamsyah R Firman , Alim Andi , Minarti S Asriani
Published: August 2023

The use of PPE is closely related to occupational diseases caused by work factors or diseases acquired while doing work and occur over a long period. This study aimed to determine the relationship between Knowledge, Compliance with the use of PPE, Availability of PPE, Implementation of Standard Operating Procedures (SOP) for the use of PPE and PPE Implementation Policy with Occupational Disease Risk Control. This research is quantitative with an analytic survey approach using a cross-sectional study method. The population in this study were all health workers with a total sample of 28; the sample was all nurses/doctors and midwives. Based on the square or comparative test results to determine the relationship between occupational disease risk control. The results showed that there was no relationship between knowledge (P=0.608), there was a relationship between the availability of Personal Protective Equipment (PPE) (P=0.002), Standard Operating Procedures (SOP) (P=0.004), Compliance with using Personal Protective Equipment (PPE) (P = 0.000). There is no relationship between policy (P = 0.0604) and controlling the risk of occupational diseases. Interventions are needed to ensure the availability of personal protective equipment (PPE) such as masks, and protective goggles, adherence to the use of self- protection equipment (PPE), and the implementation of Standard Operating Procedures (SOP) in each unit requires complete control so that the Standard Operating Procedures (SOP) are implemented, and adherence to the use of Personal Protective Equipment (PPE) requires awareness/not negligence in using Personal Protective Equipment (PPE) when serving patients to avoid risks occupational illness.
Soft skills or digital skills: Is This the Question? Genesis of a workshop
Authors: Cecco Serena
Published: August 2023

Demand for skills building is increasing more than ever and it has only been accelerated by the COVID-19 pandemic. Digitalisation and globalisation are the driving factors, thus requiring not only digital skills but also soft skills. New and ever-changing contexts require new and flexible training approaches. Performative teaching and learning has proven to be instrumental in helping to develop emotional and social skills, but it is best suited for face-to-face pedagogical contexts, or is it? This article will describe the elements of a workshop that aimed to train soft skills. It was inspired by an online training module in which the teachers applied a performative approach to train digital skills. The module was an integral part of an innovative, interdisciplinary, and interactive workshop, Active Learning Lab (ALL-EM), organised at Ca’ Foscari University. An abridged and adapted version of this workshop was presented at the 8th Scenario Forum Sore back, square eyes? Going performative in digital teaching and learning spaces (18/19 June 2021, online).
Designing, Planning & Implementation of IT Infrastructure & Security for A Brokerage House
Authors: Tahir Muhammad , Rafiq Asim , Hassan Danish
Published: August 2023

M-Commerce is widely known as wireless network technology, use as the essential means of communication forbusiness transactions. Mobile commerce is seen as an augmentation of E-commerce empowered by cell phones.Transactions either indirectly or directly carried out or supported through mobile phones. ABC Brokerage House is the pioneer in Online Trading Services. In online trade, customers can trade using the online trade software and website. Before switching users, from traditional trading system to mobile trading system, the weaknesses of infrastructure, security breaches, and risk factors should be considered carefully. The infrastructure solution should be designed with respect to interoperability, security, scalability, non-repudiation of ABC Brokerage House on the behalf of best practices for Mobile Commerce Trading System. The solution has its distributed nature and is a suitable architecture for managing business processes of ABC Stock Brokerage House. The solution is wellplanned, designed and it is in accordance with ISO recommendation. The solution provides more flexibility and alsoprovides redundancy by using clustering of database server. The proposed solution provides more flexibility and also provides redundancy plan and clustering of database server. This solution also switches ABC Brokerage House infrastructure to the real world infrastructure by removing risk factors and implementing the latest technologies.
Tackling Demolition Waste – An en route to Sustainable Development
Authors: Qamar Nadia , Khurram Ayesha Alam
Published: August 2023

In Pakistan, construction and demolition waste (CDW) is generated in voluminous amount each year. CDW iswidely ill-handled and ultimately fed to landfills causing harm to the already alarming environmental conditions. In order to search for the solution of this drastic matter, a study was done, which is explained in this paper. This paper presents the study done at a demolition site near Karachi, in Sindh while the demolition works were being carried out. At the site there were old barracks which were being demolished. Before the demolition works were commenced, the site was surveyed and structural components of the barracks were counted and their dimensionswere measured. When the demolition was over, the demolished waste was calculated which comprised of concrete and masonry rubble, steel round bars, steel doors, steel windows, steel ceiling, steel girders, steel main gate, and plastic water tank. This study interpreted that construction and demolition (C&D) works were progressing considering the works’ deadline and the clients’ requirements but the ecosystem’s ecology and the environmentalhealth were not taken into account. Recommendations are made to handle CDW properly throughout its lifecycle. These recommendations aim to provide technological and logical solutions to grip CDW. The recommendations include waste reduction and reusing waste, life cycle assessment and costing, environmental and economic impact, material flow analysis, and advanced computerized-tools.
Optimizing the Material, Inter-distance and Temperature Effect of Intramuscular Electrodes used to Stimulate the Thoracic Diaphragm
Authors: Fatima Uruj , Woo Sang Hyo , Kim Jee Hyun , Cho Jin Ho , Qadri M. Tahir , Din Zia Mohy-Ud-
Published: August 2023

The technique of electrically stimulating thethoracic diaphragm is conducted by implanting a diaphragmaticpacemaker, in which the phrenic nerve is stimulated, resulting instimulating the diaphragm. A diaphragmatic pacemaker isusually implanted for a long period of time. Intramuscularelectrodes can be used for stimulating the diaphragm, for suchconditions in which phrenic nerve stimulation cannot be done.The material and inter-distance of the stimulation electrodes arevery important in order to stimulate the diaphragm in efficientmanner. This paper explains the Optimization of material, interdistanceand temperature effect of intramuscular electrodes usedto stimulate the thoracic diaphragm. A model has beenconstructed and simulated on the software COMSOL Multiphysics,whose results shows that the threshold musclestimulation is achieved when 1 volt is applied at the electrode, 15cm apart from each other. The result further suggested that thiskind of electrical stimulation cannot produce significant thermaleffect on the tissues.
Pattern Recognition for Healing Burns to Compute Evidence: Space Syntax and Machine Learning Analysis of Burns Center Karachi
Authors: Shaikh Javaria Manzoor , Park JaeSeung
Published: August 2023

Usually elongated hospitalization is experienced byBurn patients, and the precise forecast of the placement of patientaccording to the healing acceleration has significant consequenceon healthcare supply administration. Substantial amount ofevidence suggest that sun light is essential to burns healing andcould be exceptionally beneficial for burned patients andworkforce in healthcare building. Satisfactory UV sunlight isfundamental for a calculated amount of burn to heal; this delicaterather complex matrix is achieved by applying patternclassification for the first time on the space syntax map of the floorplan and Browder chart of the burned patient. On the basis of thedata determined from this specific healthcare learning technique,nurse can decide the location of the patient on the floor plan, hencepatient safety first is the priority in the routine tasks by staff inhealthcare settings. Whereas insufficient UV light and vitamin Dcan retard healing process, hence this experiment focuses onmachine learning design in which pattern recognition andtechnology supports patient safety as our primary goal. In thisexperiment we lowered the adverse events from 2012- 2013, andnearly missed errors and prevented medical deaths up to 50%lower, as compared to the data of 2005- 2012 before this techniquewas incorporated.In this research paper, three distinctive phases of clinicalsituations are considered—primarily: admission, secondly: acute,and tertiary: post-treatment according to the burn pattern andhealing rate—and be validated by capable AI- origin forecastingtechniques to hypothesis placement prediction models for eachclinical stage with varying percentage of burn i.e. superficialwound, partial thickness or full thickness deep burn. Conclusivelywe proved that the depth of burn is directly proportionate to thedepth of patient’s placement in terms of window distance. Ourfindings support the hypothesis that the windowed wall is mosthealing wall, here fundamental suggestion is support vectormachines: which is most advantageous hyper plane for linearlydivisible patterns for the burns depth as well as the depth map isused.
Maximum Likelihood Decoder for Variable Length Codes
Authors: Misbahuddin Syed , Simsim Mohammed Talal
Published: August 2023

Variable Length Codes (VLC) are used to transfer same amount of digital information in relatively short period of time. In variable length coding, the characters with higher probability of occurrence are assigned shorter bits sequence and the characters with less probability of occurrence are assigned relatively longer bits sequence. However, due to variable length nature of codes, the decoding circuitry at the receiving end loses the synchronization due to single or multiple bit inversions. This typically happens when data is transmitted through a Binary Symmetric Channel (BSC). This paper investigates synchronizing scheme to control the error propagation due to single or multiple bit inversions through BSC. The hardware implementation of the proposed algorithm has been presented using a hardware description language. The functional level simulation of the implementation is discussed to test the proposed algorithm.
FAKTOR-FAKTOR PENYEBAB RENDAHNYA KESADARAN HUKUM MASYARAKAT DALAM MEMBAYAR ZAKAT PERTANIAN DI KABUPATEN REJANG LEBONG
Authors: Bastian Adi
Published: August 2023

Zakat adalah perintah wajib dan merupakan rukun Islam yang ketiga. Di lingkungan masyarakat ada banyak permasalahan yang terjadi, seperti ketidaksesuaian antara teori dan praktek pelaksanaan zakat. Dalam zakat sudah diatur dengan tegas ketentuan dan ancaman apabila zakat tidak dilaksanakan. Di Kabupaten Rejang Lebong, banyak masyarakat petani muslim yang tidak mengetahui adanya zakat pertanian. Oleh sebab itu, peneliti tertarik untuk melakukan penelitian dengan judul Faktor-Faktor Penyebab Rendahnya Kesadaran Hukum Masyarakat Dalam Membayar Zakat Pertanian Di Kabupaten Rejang Lebong. Tujuan yang ingin dicapai yaitu : (1) untuk mengetahui bagaimanakah kesadaran hukum masyarakat dalam membayar zakat dari hasil pertanian di Kabupaten Rejang Lebong; (2) faktor apa saja yang mempengaruhi tingkat kesadaran petani dalam mengeluarkan zakat hasil pertanian Di Kabupaten Rejang Lebong. Penulis menggunakan metode penelitian hukum empiris. Data diolah dengan menggunakan pemeriksaan data (editing), dn dianalisis secara kualitatif. Hasil penelitian menunjukan bahwa: (1) kesadran masyarakat petani muslim Di Kabupaten Rejang Lebong masih sangat rendah. Karena banyak masyarakat yang melaksanakan zakat tidak sesuai dengan nisab dan haulnya. (2) Adapun faktor yang mempengaruhi tingkat kesadaran masyarakat dalam membayar zakat pertanian, seperti kurangnya sosialisasi dari tokoh agama maupun pemerintah, kurangnya keingintahuan masyarakat akan kewajiban sebagai umat muslim, rendahnya tingkat pendidikan yang berpengaruh terhadap luasnya pengetahuan dan pemahaman mengenai zakat. Dari hasil penelitian tersebut menggambarkan bahwa masih rendahnya tingkat kesadaran masyarakat muslim dalam membayar zakat pertanian Di Kabupaten Rejang Lebong.
PRINSIP PERTANGGUNGJAWABAN ADVOKAT TERHADAP PENDAMPINGAN HUKUM DALAM PERSPEKTIF PERATURAN PERUNDANG-UNDANGAN
Authors: Suherman Asep
Published: August 2023

Advokat memiliki peran penting dalam rangka membantu masyarakat pencari keadilan untuk memenuhi hak hukumnya yang berhadapan dengan hukum. Sebagai suatu profesi yang mulia dan terhormat, dalam menjalankan tugas profesinya advokat diharapkan dapat bertindak secara profesional dan tidak berlaku diskriminatif memberikan layanan bantuan hukum kepada masyarakat. Karenanya perlu diketahui kedudukan advokat dalam peraturan perundang-undangan dan sanksi yang diberikan bila tidak melaksanakan kewajiban yang melekat padanya secara profesional. Dalam penelitian ini menggunakan metode penelitian normatif dengan pendekatan konseptual dan pendekatan perundang-undangan. Dilakukan dengan cara meneliti bahan pustaka dan data sekunder. Bahan hukum dikumpulkan dan dianalisis kemudian dideskripsikan dalam bentuk kalimat untuk menjawab permasalahan dalam tulisan. Dengan diketahuinya kedudukan advokat dan ancaman sanksi yang diterapkan, dapat membuat advokat lebih bertanggung jawab melaksanakan tugas profesinya, memberikan batasan, ketegasan, kejelasan terhadap suatu perbuatan yang diperbolehkan dan/atau dilarang untuk dilakukan, serta meminimalisir tindakan tidak profesional yang dapat merusak citra dan martabat profesinya dalam memberikan bantuan hukum.
KLARIFIKASI PEMERINTAH DAERAHKABUPATEN KAUR TERHADAP PERATURAN DESA
Authors: Nika Tita , Suryaningsih PE. , Susanti Pipi
Published: August 2023

Pemerintah Desa diberikan kewenangan untuk membentuk peraturan sebagai landasan hukum bagi kebijakan dalam penyelenggaraan Pemerintahan Desa dan pembangunan desa. Namun dewasa ini banyak Peraturan Desa yang dalam pembentukannya tidak sesuai dengan Permendagri Nomor 111 tahun 2014 tentang Pedoman Teknis Peraturan di Desa. Bersadarkan kondisi latarbelakang diatas rumusan masalah dalam penelitian ini yaitu, apakah klarifikasi Pemerintah Daerah Kabupaten Kaur terhadap Peraturan Desa telah sesuai dengan peraturan perundang-undangan, serta akibat hukum Peraturan Desa yang berlaku walaupun bertentangan dengan peraturan perundang-undangan. Metode Penelitian yang digunakan yaitu hukum empiris dengan menggunakan pendekatan pendekatan non doktrial dan pendekatan perundang-undangan (statue approach). Hasil penelitian yang didapat bahwa pelaksanaan klarifikasi terhadap Peraturan Desa oleh Pemerintah Daerah Kabupaten Kaur tidak terlaksana sebagimana yang telah diatur dalam Pasal 19 dan Pasal 20 Permendagri Nomor 111 Tahun 2014 tentang Pedoman Teknis Peraturan di Desa. Peraturan Desa yang ada di Kecamatan Tetap, Kecamatan Kaur Selatan dan Kecamatan Maje tidak memenuhi syarat formil pembentukan Peraturan Desa. Walaupun secara normatif Peraturan Desa tersebut cacat formil dan terindikasi memenuhi kebatalan sebagai regulasi, namun sampai saat ini Peraturan Desa tersebut masih berlaku.
Kata Kunci : Klarifikasi, Peraturan Desa, Pemerintah Daerah
PELAKSANAAN TANGGUNGJAWAB NEGARA TERHADAP PERUBAHAN IKLIM BERDASARKAN PERJANJIAN PARIS 2015
Authors: Nasution Sharfina Azalia , Waryenti Deli , Muthia Arini Azka
Published: August 2023

Berbagai bencana alam terjadi dikarenakan perubahan iklim yang disebabkan oleh aktivitas manusia yang berlebihan. Kesadaran masyarakat internasional dalam mengatasi permasalahan iklim telah dibuktikan dengan disahkannya Perjanjian Paris 2015. Berdasarkan kondisi latar belakang diatas, rumusan masalah dalam penelitian ini yaitu tanggungjawab negara terhadap perubahan iklim serta pelaksanaan tanggungjawab tersebut sebelum dan sesudah Perjanjian Paris 2015. Metode penelitian yang digunakan yaitu hukum normatif dengan pendekatan undang-undang dan pendekatan konseptual. Hasil penelitian yang didapatkan yaitu, terdapat beberapa tanggungjawab negara yang terkandung dalam Perjanjian Paris antara lain tanggungjawab dalam menurunkan emisi gas rumah kaca, tanggungjawab dalam melakukan konservasi lingkungan, dantanggungjawab dalam menghindari kerugian dari perubahan iklim. Dalam melaksanakan tanggungjawab tersebut terdapat beberapa cara yang dapat dilakukan seperti melalui upaya mitigasi dan adaptasi, pendanaan iklim, pengembangan mekanisme teknologi, kerjasama internasional, dan pendidikan iklim. Walaupun tanggungjawab tersebut sudah diatur, namun pelaksanaannya pada negara-negara belum dapat terlaksana secara maksimal dikarenakan beberapa kendala seperti kurangnya pasokan dana, dan kurangnya keterampilan terhadap teknologi.

Kata kunci: Perjanjian Paris 2015, Tanggungjawab Negara, Perubahan Iklim.
IMPLEMENTASI PASAL 20 UNDANG-UNDANG NOMOR 10 TAHUN 2009 TENTANG KEPARIWISATAAN TERHADAP HAK-HAK WISATAWAN DI OBJEK WISATA PANTAI JAKAT BENGKULU
Authors: Mardayanti Syakina , Ganefi Ganefi , Sofyan Tito
Published: August 2023

Pariwisata merupakan salah satu sektor terbesar yang memiliki pengaruh dalam pertumbuhan ekonomi di Indonesia. Agar dapat dikelola dengan baik Pemerintah mengatur kedalam Undang-Undang Nomor 10 Tahun 2009 tentang Kepariwisataan dengan tujuan memberikan batasan dan arah demi terwujudnya kemajuan pariwisata. Salah satu wisata unggulan yang ada di Provinsi Bengkulu yaitu Pantai Jakat dengan panorama pemandangan lautan yang indah. Terlepas dari keindahan alam yang diberikan tentu perlindungan hukum terhadap wisatawan harus diprioritaskan agar tidak terjadi kerugian yang dapat dialami wisatawan. Penelitian ini bertujuan untuk menganalisis impementasi dari Pasal 20 Undang-Undang Nomor 10 Tahun 2009 tentang Kepariwisataan di Objek Wisata Pantai Jakat Bengkulu belum dapat dilakukan secara maksimal serta solusi apa yang dapat dilakukan dalam rangka melindungi wisatawan di objek wisata Pantai Jakat Bengkulu. Jenis penelitian yang digunakan yaitu penilitian secara empiris. Berdasarkan hasil yang didapat dalam penelitian ini bahwa belum diterapkan secara maksimal hak-hak wisatawan karena kurangnya kesadaran hukum dari berbagai pihak yang terkait namun pengelolaan dan pengembangan serta peningkatan pariwisata akan selalu dilakukan. Upaya yang dapat dilakukan yaitu dengan meningkatkan kerjasama antara stakeholders, pelaku usaha dan wisatawan serta meningkatkan pemahaman sadar hukum dan sadar wisata.

Kata kunci : implementasi, perlindungan, hak wisatawan
PENGGUNAAN KEKUATAN MILITER OLEH RUSIA TERHADAP UKRAINA BERDASARKAN HUKUM INTERNASIONAL
Authors: Akbar M. Yusuf , Andika Tri , Waryenti Deli
Published: August 2023

Konflik telah ada sejak awal terciptanya peradaban manusia. Negara sebagai subyek hukum internasional tidak lepas dari yang namanya konflik. Penggunaan kekuatan militer Rusia terhadap Ukraina adalah contoh konflik antar negara. Piagam PBB melarang suatu negara untuk menggunakan kekuatannya terhadap negara lain dan dapat menggunakan kekuatannya hanya untuk membela diri, dan pembelaan diri hanya terjadi ketika serangan bersenjata telah terjadi di wilayahnya. Perang antara Rusia dan Ukraina diatur oleh Konvensi Den Haag tahun 1899 dan 1907, Konvensi Jenewa tahun 1949 dan Protokol Tambahan I dan II tahun 1977. Semua perjanjian tersebut pada dasarnya mendikte agar semua negara hidup damai satu sama lain dan saling melindungi setiap negara, tetapi instrumen hukum internasional yang masih belum dapat mencegah Rusia menggunakan kekuatan militer terhadap Ukraina. Studi ini menganalisis pengaturan hukum internasional terkait dengan konflik militer antara Rusia dan Ukraina dan tanggung jawab hukum atas konflik yang diakibatkannya. Metode penelitian yang digunakan adalah penelitian hukum normatif dan pemikiran konseptual. Hasil penelitian menunjukkan bahwa penggunaan kekuatan militer oleh Rusia merupakan Tindakan ilegal dan bertentangan dengan pengaturan hukum internasional yang ada dan diperlukan mekanisme penegakan hukum yaitu Pengadilan Internasional ad hoc atas kejahatan invasi Rusia terhadap Ukraina.
Kata kunci: Hukum Internasional; Kekuatan Militer, Pertahanan Diri.
PENUNDAAN PELAKSANAAN PERJANJIAN ANTARA PENGGUNA JASA DENGAN WEDDING ORGANIZER PADA MASA PANDEMI COVID-19 DI KOTA BENGKULU
Authors: Mexiarli Afrial , Dwi Arso Dimas , Muljono Slamet , Edytiawarman Edytiawarman
Published: August 2023

Penelitian ini bertujuan untuk mengetahui dan mendeskripsikan Pelaksanaan kerjasama pengguna jasa dengan wedding organizer pada masa covid-19 di Kota Bengkulu Adapun jenis penelitian ini adalah penelitian hukum empiris, dengan metode penelitian kualitatif. Hasil penelitian bahwa: (1). Pelaksanaan kerjasama pengguna jasa dengan Wedding organizer pada masa covid-19 di Kota Bengkulu telah memenuhi unsur force majeure dan pandemi Covid-19 dapat dikualifikasikan sebagai force majeure, karena pada saat pandemi melanda, Pemerintah Indonesia telah menyatakan pandemi Covid-19 sebagai bencana nasional non-alam dengan dikeluarkannya KEPPRES Nomor 12 Tahun 2020 tentang Penetapan Bencana Non-alam Penyebaran coronavirus Disease 2019. Perizinan pernikahan di Kota Bengkulu harus mematuhi protokol kesehatan dan harus ada rekomendasi dari satgas covid-19 serta memenuhi syarat-syarat yang sudah ditentukan, apabila syarat tersebut dilanggar maka tim Satgas covid-19 Kota Bengkulu tidak akan mengeluarkan izin bahkan jika tetap berlangsung akan dibubarkan. Serta jika izin telah dikeluarkan maka harus ditunda dikarenakan munculnya penyebaran covid-19. Maka dari pada itu secara langsung membuat Focus Wedding Organizer tidak lagi dianggap wanprestasi, tetapi hanya diklasifikasikan sebagai force majeure. Di mana dengan terjadinya penundaan pelaksaan perjanjian tersebut membuat Focus Wedding Organizer dan pengguna jasa saling menyelesaikan. (2) Penyelesaian sengketa pada perjanjian pengguna jasa dengan Wedding Organizer dengan AA dan NE akibat keadaan covid-19. Dilakukan dengan musyawarah dan mufakat dimana pihak yang dirugikan akhirnya meminta biaya ganti rugi yang mana dalam kasus ini jumlah yang harus dibayar disetiap bulannya adalah sebesar Rp.1.645.000 (sejuta enam ratus empat puluh lima ribu rupiah) yang dibagi menjadi 5 bulan. Pembayaran angsuran akan di lakukan di setiap tanggal 20 dimulai dari bulan November dan 2020 berakhir pada bulan April 2021.

Kata Kunci : Perjanjian; Penyelesaian Sengketa; Wanprestasi.
IMPLEMENTASI PERATURAN MENTERI KEUANGAN NOMOR 190/PMK.07/2021 TENTANG PENGELOLAAN DANA DESA DI KECAMATAN BANG HAJI KABUPATEN BENGKULU TENGAH
Authors: Nopita Reza , Wulandari Wulandari , Suryaningsih Patricia Ekowati
Published: August 2023

Bantuan Langsung Tunai Dana Desa adalah bantuan berupa uang yang diberikan kepada keluarga miskin di desa yang bersumber dari dana desa untuk mengurangi dampak pendemi COVID-19. Dalam proses pembagian BLT Dana Desa terdapat 6 kriteria yang diatur dalam Pasal 33 ayat (1) Peraturan Menteri Keuangan Nomor 190/PMK.07/2021 tentang Pengelolaan Dana Desa. Penelitian ini bertujuan untuk mengetahui bagaimana implementasi dan faktor penghambat implemetasi Peraturan Menteri Keuangan Nomor 190/PMK.07/2021 tentang Pengelolaan Dana Desa di Kecamatan Bang Haji Kabupaten Bengkulu Tengah. Penelitian ini merupakan penelitian hukum empiris. Hasil penelitian ini menunjukkan bahwa implementasi Peraturan Menteri Keuangan Nomor 190/PMK.07/2021 tentang Pengelolaan Dana Desa di Kecamatan Bang Haji Kabupaten Bengkulu Tengah belum sesuai dengan Pasal 33 ayat (1), dimana seharusnya ada beberapa  kriteria penerima Bantuan Langsung Tunai (BLT) Dana Desa, namun pada Desa Padang Burnai seluruh warga mendapatkan BLT tanpa memperhatikan kriteria yang telah ditentukan oleh pemerintah pusat, kecuali warga yang telah mendapatkan bantuan lainnya dari pemerintah. Sedangkan pada Desa Taba Tengah BLT Dana Desa diberikan kepada warga yang memenuhi kriteria yang telah ditentukan oleh pemerintah pusat. Adapun yang menjadi faktor penghambat dalam pengimplementasian Peraturan Menteri Keuangan Nomor 190/PMK.07/2021 tentang Pengelolaan Dana Desa di Kecamatan Bang Haji diantaranya faktor penghambat dari sisi Pemerintah dan dari sisi Masyarakat.

 

Kata Kunci : PMK No. 190, implementasi, dana desa, bantuan langsung tunai.
TRANSLATION SHIFTS AND EQUIVALENCE STRATEGY PRODUCED BY INSTAGRAM MACHINE TRANSLATION
Authors: Antika Ria
Published: August 2023

The fast advancement of technology forces people to use it to simplify their lives. In the translation field, besides human translator, there is also machine translator used to help people in transferring the meaning of a text from source language (SL) to target language (TL). Along with the development of technology and social media, Instagram as one of the most famous social media platforms launched Instagram Machine Translation in 2016 that can help people to translate the captions and comments posted by the users. This study was conducted to identify the types of translation shift and the types of translation equivalence performed by Instagram machine translation in translating the captions on @instagram account from English to Indonesian. By using descriptive qualitative method to reach the goals of the study, the appropriate data were obtained. The data were analyzed based on the translation shifts theory from Catford (1965) and translation equivalence by Nida (1964). The findings showed that all types of Catford’s translation shifts were found in the translation process and the most common type was structure shift. It was also found that Instagram machine translation was successful in transferring the message from SL to TL equivalently.

Keywords: Translation shift, Translation equivalence, Instagram Machine Translation
Activation of the 5-hydroxytryptamine Degradation System in Cells and Organ Injury
Authors: Fu Jihua
Published: August 2023

This paper summarizes the research results of Fu et al. on the pathological mechanism of organ injury. A hypothesis was proposed that "organ injury is a consequence of the activation of the 5-hydroxytryptamine degradation system (5DS) axis in cells". The basic composition of the 5DS axis in cells and the principle of its activation leading to cell lesions were determined. The possibility of treating various organ injury diseases in clinical practice by inhibiting the 5DS axis is discussed.
SISTEM INFORMASI PEMBAYARAN BERBASIS RFID PADA PONDOK TAHFIDH YANB’UL QUR’AN 3 BATAM
Authors: Lim Tommy , Silalahi Mesri
Published: August 2023

The rapid development of information and technology in the digital era has resulted in new technologies appearing that seem endless, especially in the field of education. One of them is in Islamic boarding schools, where the use of this technology includes computers as a means in the process of learning and communicating Arabic writing, Islamic boarding school academic information systems, and cooperative payment information systems. Tahfidh Yanbu'ul Qur'an 3 Batam Islamic boarding school is a branch of Tahfidh Yanbu'ul Qur'an Kudus under the auspices of the Arwaniyyah Foundation. The problem being faced by students and cooperative officers is during snack breaks at the cottage cooperative because the payment process is on a First Come First Serve basis, so it is very time consuming. From these problems, it is necessary to build a payment information system that can simplify and speed up the students to make the payment process in the cooperative. The purpose of this research is to design and build an RFID-based payment information system that is expected to speed up the payment process in cooperatives. The method used by the author is SDLC with the development of an agile Scrum model. With the results of the research that the system that has been built and designed has helped the productivity of the cottage in terms of effectiveness and efficiency.
ANALISIS HEADLOSS PADA JARINGAN PERPIPAAN DISTRIBUSI AIR BERSIH DI PERKEBUNAN MARINA KOTA BATAM
Authors: Gumilang Reno Reza , Asmarawati Citra Indah
Published: August 2023

The rapid population growth will be directly proportional to the need for clean water, so that sooner or later various problems will arise in fulfilling the need for clean water. Marina Plantation, which is located in the city of Batam, is an area where the majority of the population work as gardeners and breeders. The increase in population and the expansion of the plantation area have resulted in a decrease in the burden on the clean water network. In this study the method used is a quantitative method using the Darcy Weisbach calculation formula with the help of Excel software to simplify calculations. Based on the head loss calculation. The technical specifications of the existing pumps are designed only to pump water with a capacity of 4 m3/h with a head of 12 m. To ensure that the existing pumps are no longer able to meet the current water demand. it is necessary to design a pump with a capacity of 10,314 m3/h +30% with a head of 19 m, and further analysis is needed, for example calculating the required pump driving force and the NPSH available in the installation.
Tumor-targeted bioactive nanoprobes visualizing of hydrogen peroxide for forecasting chemotherapy-exacerbated malignant prognosis
Authors: Zhang Fan , Jia Yong , Chen Fangman , Zhao Yawei , Li Li , Chang Zhimin
Published: August 2023

Introduction: Fluorescent visualization of hydrogen peroxide in the tumor microenvironment (TME) is conducive to predicting malignant prognosis after chemotherapy. Two photon microscopy has been employed for in vivo hydrogen peroxide detection owing to its advantages of deep penetration and low phototoxicity.

Methods: In this study, a two-photon fluorescent probe (TPFP) was protected by mesoporous silica nanoparticles (MSNs) and masked by cloaking the cancer cell membranes (CM), forming a tumor-targeted bioactive nanoprobe, termed MSN@TPFP@CM.

Results: This multifunctional nanoprobe allowed for the effective and selective detection of excessive hydrogen peroxide production in chemotherapeutic Etoposide (VP-16)-challenged tumor cells using two-photon microscopy. After specific accumulation in tumors, VP-16-MSN@TPFP@CM monitored tumor-specific hydrogen peroxide levels and revealed a positive correlation between oxidative stress in the TME and chemotherapy-exacerbated malignant prognosis.

Discussion: Given the recent translation of fluorescent imaging into early clinical trials and the high biocompatibility of bioactive nanoprobes, our approach may pave the way for specific imaging of oxidative stress in solid tumors after treatment and provide a promising technology for malignant prognosis predictions.
Decision-making approaches for optimal seismic/energy integrated retrofitting of existing buildings
Authors: Caruso Martina , Couto Rita , Pinho Rui , Monteiro Ricardo
Published: August 2023

Given the ambitious targets of carbon emission reduction set for the very near future, it is now expected that retrofitting operations on existing buildings aim both at reducing their operational energy consumption and at improving their seismic performance. Indeed, it is now well acknowledged that, if a sole energy efficiency upgrade is provided to a given building, in case of an earthquake occurrence, double economic and environmental losses will be experienced due to both the lost investment for energy retrofitting and the repair and retrofitting activities for post-earthquake damage. Moreover, social losses may also be experienced in terms of casualties, injured or homeless due to the seismic and structural deficiencies of the existing structure. To aid thus the process of a coupled seismic/energy renovation of the existing building stock, several multi-criteria decision-making (MCDM) approaches have been developed for the identification of optimal retrofitting solutions for buildings. Such procedures typically consider a range of economic, social, technical, and, more recently, environmental aspects that are assumed to be of interest to decision makers (e.g., installation cost, duration of works, architectural impact, need for specialised workers, etc.). The present study demonstrates the application to a case-study school building of two different MCDM approaches, which account for seismic vulnerability and energy efficiency, as well as related environmental impacts of buildings. The main differences between the two procedures are explored in terms of considered decision-making parameters and corresponding weights, rankings of retrofitting options and identification of the optimal retrofitting strategies.
Highly efficient morpholine-based organocatalysts for the 1,4-addition reaction between aldehydes and nitroolefins: an unexploited class of catalysts
Authors: Vaghi Francesco , Facchetti Giorgio , Rimoldi Isabella , Bottiglieri Matteo , Contini Alessandro , Gelmi Maria Luisa , Bucci Raffaella
Published: August 2023

Many studies have demonstrated how the pyrrolidine nucleus is more efficient than the corresponding piperidine or morpholine as organocatalysts in the condensation of aldehydes with electrophiles via enamine. Focussing on morpholine–enamines, their low reactivity is ascribed to the presence of oxygen on the ring and to the pronounced pyramidalisation of nitrogen, decreasing the nucleophilicity of the enamine. Thus, the selection of efficient morpholine organocatalysts appears to be a difficult challenge. Herein, we reported on the synthesis of new organocatalysts belonging to the class of ß-morpholine amino acids that were tested in a model reaction, i.e., the 1,4-addition reaction of aldehydes to nitroolefins. Starting from commercially available amino acids and epichlorohydrin, we designed an efficient synthesis for the aforementioned catalysts, controlling the configuration and the substitution pattern. Computational studies indeed disclosed the transition state of the reaction, explaining why, despite all the limitations of the morpholine ring for enamine catalysis, our best catalyst works efficiently, affording condensation products with excellent yields, diastereoselection and good-to-exquisite enantioselectivity.
High specificity of metagenomic next-generation sequencing using protected bronchial brushing sample in diagnosing pneumonia in children
Authors: Zhang Chunyan , Li Zheng , Wang Mengyuan , Zhou Jiemin , Yu Wenwen , Liu Huifang , Hu Bingxue , Wang Shifu
Published: August 2023

Background

Lower respiratory tract infections are the leading cause of morbidity and mortality in children worldwide. Timely and accurate pathogen detection is crucial for proper clinical diagnosis and therapeutic strategies. The low detection efficiency of conventional methods and low specificity using respiratory samples seriously hindered the accurate detection of pathogens.

Methods

In this study, we retrospectively enrolled 1,032 children to evaluate the performance of metagenomics next-generation sequencing (mNGS) using bronchoalveolar lavage fluid (BALF) sample and protected bronchial brushing (BB) sample in diagnosing pneumonia in children. In addition, conventional tests (CTs) were also performed.

Results

The specificity of BB mNGS [67.3% (95% CI 58.6%–75.9%)] was significantly higher than that of BALF mNGS [38.5% (95% CI 12.0%–64.9%)]. The total coincidence rate of BB mNGS [77.6% (95% CI 74.8%–80.5%)] was slightly higher than that of BALF mNGS [76.5% (95% CI 68.8%–84.1%)] and CTs [38.5% (95% CI 35.2%–41.9%)]. During the epidemics of Mycoplasma pneumoniae, the detection rate of M. pneumoniae in the >6-year group (81.8%) was higher than that in the 3–6-year (78.9%) and <3-year groups (21.5%). The highest detection rates of bacteria, fungi, and viruses were found in the <3-year, >6-year, and 3–6-year groups, respectively. mNGS detection should be performed at the duration of 5–7 days after the start of continuous anti-microbial therapy or at the duration of 6–9 days from onset to mNGS test.

Conclusions

This is the first report to evaluate the performance of BB mNGS in diagnosing pulmonary infections in children on a large scale. Based on our findings, extensive application of BB mNGS could be expected.
Development and validation of a novel nomogram for predicting recurrent atrial fibrillation after cryoballoon ablation
Authors: Wei Yue , Lin Changjian , Xie Yun , Bao Yangyang , Luo Qingzhi , Zhang Ning , Wu Liqun
Published: August 2023

Background

Few studies have explored the use of machine learning models to predict the recurrence of atrial fibrillation (AF) in patients who have undergone cryoballoon ablation (CBA). We aimed to explore the risk factors for the recurrence of AF after CBA in order to construct a nomogram that could predict this risk.

Methods

Data of 498 patients who had undergone CBA at Ruijin Hospital, Shanghai Jiaotong University School of Medicine, were retrospectively collected. Factors such as clinical characteristics and biophysical parameters during the CBA procedure were collected for the selection of variables. Scores for all the biophysical factors—such as time to pulmonary vein isolation (TTI) and balloon temperature—were calculated to enable construction of the model, which was then calibrated and compared with the risk scores.

Results

A 36-month follow-up showed that 177 (35.5%) of the 489 patients experienced AF recurrence. The left atrial volume, TTI, nadir cryoballoon temperature, and number of unsuccessful freezes were related to the recurrence of AF (P < .05). The area under the curve (AUC) of the nomogram's time-dependent receiver operating characteristic curve was 77.6%, 71.6%, and 71.0%, respectively, for the 1-, 2-, and 3-year prediction of recurrence in the training cohort and 77.4%, 74.7%, and 68.7%, respectively, for the same characteristics in the validation cohort. Calibration and data on the nomogram's clinical effectiveness showed it to be accurate for the prediction of recurrence in both the training and validation cohorts as compared with established risk scores.

Conclusion

Biophysical parameters such as TTI and cryoballoon temperature have a great impact on AF recurrence. The predictive accuracy for recurrence of our nomogram was superior to that of conventional risk scores.
Inclusion of interleukin-6 improved the performance of postoperative acute lung injury prediction for patients undergoing surgery for thoracic aortic disease
Authors: Li Huili , Feng Weiqi , Wang Qiuji , Li Chenxi , Zhu Jiade , Sun Tucheng , Wu Jinlin
Published: August 2023

Background

We studied acute lung injury (ALI) in thoracic aortic disease (TAD) patients and investigated the predictive effect of interleukin-6 (IL-6) in acute lung injury after thoracic aortic disease.

Methods

Data on 188 TAD patients, who underwent surgery between January 2016 to December 2021 at our hospital, were enrolled in. We analyzed acute lung injury using two patient groups. Patients with No-ALI were 65 and those with ALI were 123. Univariate logistic, LASSO binary logistic regression model and multivariable logistic regression analysis were performed for acute lung injury.

Results

Preoperative IL-6 level was lower (15.80[3.10,43.30] vs. 47.70[21.40,91.60] pg/ml, p < 0.001) in No-ALI group than in ALI group. The cut-off points, determined by the ROC curve, were preoperative IL-6 > 18 pg/ml (area under the curve: AUC = 0.727). Univariate logistic regression analysis showed 19 features for TAD appeared to be early postoperative risk factors of acute lung injury. Using LASSO binary logistic regression, 19 features were reduced to 9 potential predictors (i.e., Scrpost + PLTpost + CPB > 182 min + D-dimerpost + D-dimerpre + Hypertension + Age > 58 years + IL6 > 18 pg/ml + IL6). Multivariable logistic regression analysis showed that Postoperative creatinine, CPB > 182 min and IL-6 > 18 pg/ml were early postoperative risk factors for ALI after TAD, and the odds ratios (ORs) of postoperative creatinine, CPB > 182 min and IL-6 > 18 pg/ml were 1.006 (1.002–1.01), 4.717 (1.306–19.294) and 2.96 (1.184–7.497), respectively. When postoperative creatinine, CPB > 182 min and IL-6 > 18 pg/ml (AUC = 0.819), the 95% confidence interval [CI] was 0.741 to 0.898. Correction curves were nearly diagonal, suggesting that the nomogram fit well. The DCA curve was then drawn to demonstrate clinical applicability. The DCA curve showed that the threshold probability of a patient is in the range of 30% to 90%.

Conclusions

The inclusion of interleukin-6 demonstrated good performance in predicting ALI after TAD surgery.