bluuebunny/crossref_metadata_2025 huggingface dataset:
The surgical treatment of Morgagni hernias in adults: a systematic review for the standardization of laparoscopic surgical repair
Authors: Schembari Elena , Reitano Elisa , Sofia Maria , Latteri Saverio , La Greca Gaetano
Published: November 2023

A Morgagni hernia is a congenital diaphragmatic hernia that is rarely diagnosed in adults, and the technique for its repair has not yet been standardized. This review will give an overview of the different laparoscopic methods reported by other authors, highlighting the key points indicating a good repair to help standardize the technique. A systematic review of the available articles on PubMed was conducted according to PRISMA 2020 by two authors independently in May 2022. Only articles written in English were included. A total of 180 case reports of laparoscopic Morgagni’s hernia repair procedures were found; direct repair was performed in 59 patients, mesh was used in 119 patients, and mesh was not used in 2 patients. The hernia sac was removed in 71 patients, and the defect was closed before mesh placement in 49 patients. Nonabsorbable, dual or biologic mesh was used. The mean operative time was 92.65 min for direct repair and 84.11 min for mesh repair. One recurrence was reported in the direct repair series. The optimal method of repair has not yet been identified. The laparoscopic approach is associated to fewer complications and facilitates a faster recovery than the open approach. Several manoeuvres have been reported to help surgeons, who are not trained in laparoscopic knotting, perform extracorporeal knotting. Mesh should be placed when tension is too high after a direct repair or when primary closure cannot be achieved.
Semiaffine stable planes
Authors: Löwen Rainer , Stroppel Markus J.
Published: November 2023

A locally compact stable plane of positive topological dimension will be called semiaffine if for every line L and every point p not in L there is at most one line passing through p and disjoint from L. We show that then the plane is either an affine or projective plane or a punctured projective plane (i.e., a projective plane with one point deleted). We also compare this with the situation in general linear spaces (without topology), where P. Dembowski showed that the analogue of our main result is true for finite spaces but fails in general.
Minimalist Training: Is Lower Dosage or Intensity Resistance Training Effective to Improve Physical Fitness? A Narrative Review
Authors: Behm David G. , Granacher Urs , Warneke Konstantin , Aragão-Santos Jose Carlos , Da Silva-Grigoletto Marzo Edir , Konrad Andreas
Published: November 2023

Background

Findings from original research, systematic reviews, and meta-analyses have demonstrated the effectiveness of resistance training (RT) on markers of performance and health. However, the literature is inconsistent with regards to the dosage effects (frequency, intensity, time, type) of RT to maximize training-induced improvements. This is most likely due to moderating factors such as age, sex, and training status. Moreover, individuals with limited time to exercise or who lack motivation to perform RT are interested in the least amount of RT to improve physical fitness.

Objectives

The objective of this review was to investigate and identify lower than typically recommended RT dosages (i.e., shorter durations, lower volumes, and intensity activities) that can improve fitness components such as muscle strength and endurance for sedentary individuals or beginners not meeting the minimal recommendation of exercise.

Methods

Due to the broad research question involving different RT types, cohorts, and outcome measures (i.e., high heterogeneity), a narrative review was selected instead of a systematic meta-analysis approach.

Results

It seems that one weekly RT session is sufficient to induce strength gains in RT beginners with < 3 sets and loads below 50% of one-repetition maximum (1RM). With regards to the number of repetitions, the literature is controversial and some authors report that repetition to failure is key to achieve optimal adaptations, while other authors report similar adaptations with fewer repetitions. Additionally, higher intensity or heavier loads tend to provide superior results. With regards to the RT type, multi-joint exercises induce similar or even larger effects than single-joint exercises.

Conclusion

The least amount of RT that can be performed to improve physical fitness for beginners for at least the first 12 weeks is one weekly session at intensities below 50% 1RM, with < 3 sets per multi-joint exercise.
Observation of Blue Corona Discharges and Cloud Microphysics in the Top of Thunderstorm Cells in Cyclone Fani
Authors: Li Dongshuai , Neubert Torsten , Husbjerg Lasse Skaaning , Zhu Yanan , Chanrion Olivier , Lapierre Jeff , Luque Alejandro , Köhn Christoph , Heumesser Matthias , Dimitriadou Krystallia , Stendel Martin , Kaas Eigil , Olesen Emilie Petrea Petajamaa Wiinberg , Liu Feifan , Østgaard Nikolai , Reglero Víctor
Published: November 2023

Blue corona discharges are often observed at the top of thunderclouds. They are bursts of streamers, but the cloud conditions that enable them are not well known. Here we present observations by the Atmosphere‐Space Interactions Monitor (ASIM) of 92 discharges during its ∼1 min pass over tropical cyclone Fani in the Bay of Bengal from 20:10:55 to 20:12:05 UTC on 30 April 2019. The discharges were observed in convective cells forming in the rainbands of the cyclone where Convective Available Potential Energy reached ∼6,000 J kg−1. The Cloud‐Aerosol Lidar and Infrared Pathfinder Satellite Observation satellite passed over one of the cells ∼12 min after ASIM from 20:23:58 to 20:24:14 UTC. It measured the cloud microphysics related to the discharges and indicated they occurred in a convection region with the cloud top overshooting for over 20 min. The updraft lifted ice particles to lower stratospheric altitudes and formed the gullwing‐shaped cirrus. The discharges are found at an average altitude of ∼16 km where the cloud environment contained ∼2 × 107 m−3 ice particles with ∼50 µm radius, resulting in a photon mean free path of ∼3 m. Around 20% of the blue corona discharges coincide with Narrow Bipolar Events indentified from the Earth Networks Total Lightning Network. Our observations suggest that the overshooting cloud top formed by deep convection and a surge in lightning activity facilitated conditions for the blue corona discharges. This work provides the first‐ever estimate of important microphysical parameters related to blue corona discharges based on data measurements, establishing a reference for future empirical and theoretical studies.
Did These Curious Rock Formations Inspire the Great Sphinx?
Authors: Scharping Nathaniel
Published: November 2023

New research says it’s plausible the Great Sphinx started life as a geomorphological oddity known as a yardang.
Single‐Scattering Properties of Encapsulated Fractal Black Carbon Particles Computed Using the Invariant Imbedding T‐Matrix Method and Deep Learning Approaches
Authors: Wang Xuan , Bi Lei , Han Wei , Zhang Xiaoye
Published: November 2023

Efficient and accurate computation of the single‐scattering properties of black carbon (BC) aerosols is fundamental in various fields, including remote sensing and climate simulations. In this study, we developed a composite model of fractal aggregates of BC encapsulated with hygroscopic aerosols to represent the ambient BC. We used the invariant imbedding T‐matrix method to compute the optical properties of fully and partially encapsulated BC aerosols. In this new model, the traditional assumption of unoverlapped surfaces in the super‐position T‐matrix method is unnecessary. After extensive simulations, we established a database of single‐scattering properties, including the extinction efficiency, the single‐scattering albedo, the asymmetry factor and six phase matrix elements. Moreover, we obtained deep neural networks (DNNs) from this database using a deep learning method. These DNN models provide a universal interface for predicting the optical properties of ambient BC aerosols. Specifically, through a modified architecture of the DNN, we trained two models based on the database to predict three integrated optical properties (extinction efficiency, single‐scattering albedo, and asymmetry factor) and six phase matrix elements. We performed statistical assessments based on the true values in the database and the predicted values from the DNNs, demonstrating that the DNNs accurately predicted all single‐scattering properties. Therefore, the developed DNN models can be conveniently implemented in aerosol optical parameterization for remote sensing studies and atmospheric models.
A TRIM21-based bioPROTAC highlights the therapeutic benefit of HuR degradation
Authors: Fletcher Alice , Clift Dean , de Vries Emma , Martinez Cuesta Sergio , Malcolm Timothy , Meghini Francesco , Chaerkady Raghothama , Wang Junmin , Chiang Abby , Weng Shao Huan Samuel , Tart Jonathan , Wong Edmond , Donohoe Gerard , Rawlins Philip , Gordon Euan , Taylor Jonathan D. , James Leo , Hunt James
Published: November 2023

Human antigen R (HuR) is a ubiquitously expressed RNA-binding protein, which functions as an RNA regulator. Overexpression of HuR correlates with high grade tumours and poor patient prognosis, implicating it as an attractive therapeutic target. However, an effective small molecule antagonist to HuR for clinical use remains elusive. Here, a single domain antibody (VHH) that binds HuR with low nanomolar affinity was identified and shown to inhibit HuR binding to RNA. This VHH was used to engineer a TRIM21-based biological PROTAC (bioPROTAC) that could degrade endogenous HuR. Significantly, HuR degradation reverses the tumour-promoting properties of cancer cells in vivo by altering the HuR-regulated proteome, highlighting the benefit of HuR degradation and paving the way for the development of HuR-degrading therapeutics. These observations have broader implications for degrading intractable therapeutic targets, with bioPROTACs presenting a unique opportunity to explore targeted-protein degradation through a modular approach.
Metabolic dependencies of metastasis-initiating cells in female breast cancer
Authors: Young C. Megan , Beziaud Laurent , Dessen Pierre , Madurga Alonso Angela , Santamaria-Martínez Albert , Huelsken Joerg
Published: November 2023

Understanding the mechanisms that enable cancer cells to metastasize is essential in preventing cancer progression. Here we examine the metabolic adaptations of metastasis-initiating cells (MICs) in female breast cancer and how those shape their metastatic phenotype. We find that endogenous MICs depend on the oxidative tricarboxylic acid cycle and fatty acid usage. Sorting tumor cells based upon solely mitochondrial membrane potential or lipid storage is sufficient at identifying MICs. We further identify that mitochondrially-generated citrate is exported to the cytoplasm to yield acetyl-CoA, and this is crucial to maintaining heightened levels of H3K27ac in MICs. Blocking acetyl-CoA generating pathways or H3K27ac-specific epigenetic writers and readers reduces expression of epithelial-to-mesenchymal related genes, MIC frequency, and metastatic potential. Exogenous supplementation of a short chain carboxylic acid, acetate, increases MIC frequency and metastasis. In patient cohorts, we observe that higher expression of oxidative phosphorylation related genes is associated with reduced distant relapse-free survival. These data demonstrate that MICs specifically and precisely alter their metabolism to efficiently colonize distant organs.
Poor sleep and shift work associate with increased blood pressure and inflammation in UK Biobank participants
Authors: Kanki Monica , Nath Artika P. , Xiang Ruidong , Yiallourou Stephanie , Fuller Peter J. , Cole Timothy J. , Cánovas Rodrigo , Young Morag J.
Published: November 2023

Disrupted circadian rhythms have been linked to an increased risk of hypertension and cardiovascular disease. However, many studies show inconsistent findings and are not sufficiently powered for targeted subgroup analyses. Using the UK Biobank cohort, we evaluate the association between circadian rhythm-disrupting behaviours, blood pressure (SBP, DBP) and inflammatory markers in >350,000 adults with European white British ancestry. The independent U-shaped relationship between sleep length and SBP/DBP is most prominent with a low inflammatory status. Poor sleep quality and permanent night shift work are also positively associated with SBP/DBP. Although fully adjusting for BMI in the linear regression model attenuated effect sizes, these associations remain significant. Two-sample Mendelian Randomisation (MR) analyses support a potential causal effect of long sleep, short sleep, chronotype, daytime napping and sleep duration on SBP/DBP. Thus, in the current study, we present a positive association between circadian rhythm-disrupting behaviours and SBP/DBP regulation in males and females that is largely independent of age.
Two subtypes of GTPase-activating proteins coordinate tip growth and cell size regulation in Physcomitrium patens
Authors: Ruan Jingtong , Lai Linyu , Ou Hongxin , Yi Peishan
Published: November 2023

The establishment of cell polarity is a prerequisite for many developmental processes. However, how it is achieved during tip growth in plants remains elusive. Here, we show that the RHO OF PLANTs (ROPs), ROP GUANINE NUCLEOTIDE EXCHANGE FACTORs (RopGEFs), and ROP GTPASE-ACTIVATING PROTEINs (RopGAPs) assemble into membrane domains in tip-growing cells of the moss Physcomitrium patens. The confinement of membrane domains requires redundant global inactivation of ROPs by PpRopGAPs and the PLECKSTRIN HOMOLOGY (PH) domain-containing RenGAP PpREN. Unexpectedly, PpRopGAPs and PpREN exert opposing effects on domain size and cell width upon overexpression. Biochemical and functional analyses indicate that PpRopGAPs are recruited to the membrane by active ROPs to restrict domain size through clustering, whereas PpREN rapidly inactivates ROPs and inhibits PpRopGAP-induced clustering. We propose that the activity- and clustering-based domain organization by RopGAPs and RenGAPs is a general mechanism for coordinating polarized cell growth and cell size regulation in plants.
Mutational spectra are associated with bacterial niche
Authors: Ruis Christopher , Weimann Aaron , Tonkin-Hill Gerry , Pandurangan Arun Prasad , Matuszewska Marta , Murray Gemma G. R. , Lévesque Roger C. , Blundell Tom L. , Floto R. Andres , Parkhill Julian
Published: November 2023

As observed in cancers, individual mutagens and defects in DNA repair create distinctive mutational signatures that combine to form context-specific spectra within cells. We reasoned that similar processes must occur in bacterial lineages, potentially allowing decomposition analysis to detect both disruption of DNA repair processes and exposure to niche-specific mutagens. Here we reconstruct mutational spectra for 84 clades from 31 diverse bacterial species and find distinct mutational patterns. We extract signatures driven by specific DNA repair defects using hypermutator lineages, and further deconvolute the spectra into multiple signatures operating within different clades. We show that these signatures are explained by both bacterial phylogeny and replication niche. By comparing mutational spectra of clades from different environmental and biological locations, we identify niche-associated mutational signatures, and then employ these signatures to infer the predominant replication niches for several clades where this was previously obscure. Our results show that mutational spectra may be associated with sites of bacterial replication when mutagen exposures differ, and can be used in these cases to infer transmission routes for established and emergent human bacterial pathogens.
Double boron–oxygen-fused polycyclic aromatic hydrocarbons: skeletal editing and applications as organic optoelectronic materials
Authors: Li Guijie , Xu Kewei , Zheng Jianbing , Fang Xiaoli , Yang Yun-Fang , Lou Weiwei , Chu Qingshan , Dai Jianxin , Chen Qidong , Yang Yuning , She Yuan-Bin
Published: November 2023

An efficient one-pot strategy for the facile synthesis of double boron–oxygen-fused polycyclic aromatic hydrocarbons (dBO-PAHs) with high regioselectivity and efficient skeletal editing is developed. The boron–oxygen-fused rings exhibit low aromaticity, endowing the polycyclic aromatic hydrocarbons with high chemical and thermal stabilities. The incorporation of the boron–oxygen units enables the polycyclic aromatic hydrocarbons to show single-component, low-temperature ultralong afterglow of up to 20 s. Moreover, the boron–oxygen-fused polycyclic aromatic hydrocarbons can also serve as ideal n-type host materials for high-brightness and high-efficiency deep-blue OLEDs; compared to single host, devices using boron–oxygen-fused polycyclic aromatic hydrocarbons-based co-hosts exhibit dramatically brightness and efficiency enhancements with significantly reduced efficiency roll-offs; device 9 demonstrates a high color-purity (Commission International de l’Eclairage CIEy = 0.104), and also achieves a record-high external quantum efficiency (28.0%) among Pt(II)-based deep-blue OLEDs with Commission International de l’Eclairage CIEy < 0.20; device 10 achieves a maximum brightnessof 27219 cd/m2 with a peak external quantum efficiency of 27.8%, which representes the record-high maximum brightness among Pt(II)-based deep-blue OLEDs. This work demonstrates the great potential of the double boron–oxygen-fused polycyclic aromatic hydrocarbons as ultralong afterglow and n-type host materials in optoelectronic applications.
Transcriptional repression of beige fat innervation via a YAP/TAZ-S100B axis
Authors: Huang Xun , Li Xinmeng , Shen Hongyu , Zhao Yiheng , Zhou Zhao , Wang Yushuang , Yao Jingfei , Xue Kaili , Wu Dongmei , Qiu Yifu
Published: November 2023

Sympathetic innervation is essential for the development of functional beige fat that maintains body temperature and metabolic homeostasis, yet the molecular mechanisms controlling this innervation remain largely unknown. Here, we show that adipocyte YAP/TAZ inhibit sympathetic innervation of beige fat by transcriptional repression of neurotropic factor S100B. Adipocyte-specific loss of Yap/Taz induces S100b expression to stimulate sympathetic innervation and biogenesis of functional beige fat both in subcutaneous white adipose tissue (WAT) and browning-resistant visceral WAT. Mechanistically, YAP/TAZ compete with C/EBPβ for binding to the zinc finger-2 domain of PRDM16 to suppress S100b transcription, which is released by adrenergic-stimulated YAP/TAZ phosphorylation and inactivation. Importantly, Yap/Taz loss in adipocytes or AAV-S100B overexpression in visceral WAT restricts both age-associated and diet-induced obesity, and improves metabolic homeostasis by enhancing energy expenditure of mice. Together, our data reveal that YAP/TAZ act as a brake on the beige fat innervation by blocking PRDM16-C/EBPβ-mediated S100b expression.
Next generation sequencing uncovers multiple miRNAs associated molecular targets in gallbladder cancer patients
Authors: Saxena Rahul , Chakrapani Baskar , Sarath Krishnan M. P. , Gupta Amit , Gupta Sweety , Das Jayanta , Gupta Subash C. , Mirza Anissa A. , Rao Shalinee , Goyal Bela
Published: November 2023

Gallbladder cancer (GBC) is a lethal disease with surgical resection as the only curative treatment. However, many patients are ineligible for surgery, and current adjuvant treatments exhibit limited effectiveness. Next-generation sequencing has improved our understanding of molecular pathways in cancer, sparking interest in microRNA-based gene regulation. The aim of the study is to identify dysregulated miRNAs in GBC and investigate their potential as therapeutic tools for effective and targeted treatment strategies. GBC and control tissue samples were sequenced for miRNA expression using the Illumina HiSeq platform. Biological processes and related pathways were determined using the Panther and Gene Ontology databases. 439 significantly differentially expressed miRNAs were identified; 19 of them were upregulated and 29 were downregulated. Key enriched biological processes included immune cell apoptosis, endoplasmic reticulum (ER) overload response, and negative regulation of the androgen receptor (AR) signaling pathway. Panther analysis revealed the insulin-like growth factor (IGF)-mitogen activated protein kinases (MAPK) cascade, p38 MAPK pathway, p53 pathway, and FAS (a subgroup of the tumor necrosis factor receptor) signaling pathway as highly enriched among dysregulated miRNAs. Kirsten rat sarcoma virus (KRAS), AR, and interferon gamma (IFN-γ) pathways were identified among the key pathways potentially amenable to targeted therapy. We concluded that a combination approach involving miRNA-based interventions could enhance therapeutic outcomes. Our research emphasizes the importance of precision medicine, targeting pathways using sense and anti-sense miRNAs as potential therapies in GBC.
Comprehensive analysis of genes associated with migraine in the Indian population: a meta-analysis of genetic association studies with trial sequential analysis
Authors: Sudershan Amrit , Pushap Agar Chander , Bhagat Meenakshi , Sharma Isha , Kumar Hardeep , Digra Sanjeev K. , Kumar Parvinder
Published: November 2023

Migraine is a complex disorder with multigenic inheritance and is characterized by the cardinal symptom of unilateral headache. Many genes are responsible for increasing the susceptibility of disease within different populations. Therefore, our primary aim in this review was to catalog the many genes that have been studied in India and after collecting the necessary information, we calculated a more precise risk relationship between an identified variation and migraine. The gene and its associated risk variant were discovered in the Indian population using a PRISMA-based systematic literature review guideline from online databases such as PubMed & Google Scholar. We constructed pooled odds ratios with 95% confidence intervals using multiple genetic models. Also, we looked for heterogeneity using Cochran's Q Test and the I2 statistic. Publication bias was analyzed using Begg's and Egger's tests. A p-value less than 0.05 was judged to be statistically significant for all tests. After a critical analysis, a total of 24 studies explored about 21 genes with 31 variants out of which only nine genes have been studied more than two times in the Indian population and thus were found eligible for the meta-analysis. It has been found, that the ACE-DD variant (allele model: OR: 1.37 [1.11–1.69], I2 = 0%/ fixed model), ESR1-PvuII (allele model: OR: 1.47 [1.24–1.74], I2 = 0%/ fixed model) significantly increases the risk of migraine in Indian population. Also, a protective role of the LRP1-rs11172113variant was observed for both migraine and its clinical subtype i.e., MA (allelic model: OR of 0.65 [0.50–0.83] I2 = 44% and allele: OR: 0.54 [0.37–0.78], I2 = 52%) respectively. Overall, the results of this meta-analysis indicated that the ACE-DD variant and the ESR1-PvuII were associated with an increased risk of migraine in the Indian community, while the LRP1-rs11172113 variant was associated with protection from migraine in this population.
Experimental investigation and multi-performance optimization of the leachate recirculation based sustainable landfills using Taguchi approach and an integrated MCDM method
Authors: Khan Osama , Mufazzal Sameera , Sherwani Ahmad F. , Khan Zahid A. , Parvez Mohd , Idrisi Mohammad Javed
Published: November 2023

Landfill leachates contain harmful substances viz. chemicals, heavy metals, and pathogens, that pose a threat to human health and the environment. Unattended leachate can also cause ground water contamination, soil pollution and air pollution. This study focuses on management of leachate, by recirculating the rich, nutrient-filled fluid back into the landfills, turning it to a bioreactor, thereby maximising the performance parameters of landfills favourable for electricity production by the waste to energy plants. This study demonstrates a sustainable alternative method for utilising the fluid, rather than treating it using an extremely expensive treatment process. Further, it also experimentally investigates the effect of varying levels of five input parameters of the landfill including waste particle size, waste addition, inorganic content in waste, leachate recirculation rate, and landfill age, each at five levels, on the multiple performance of the landfill using Taguchi’s L25 standard orthogonal array. Experimental results are analysed using an integrated MCDM approach i.e. MEREC-PIV method and statistical techniques such as analysis of mean (ANOM) and analysis of variance (ANOVA). The results indicate that the optimal setting of the input parameters is waste particle size at 9 ppm, waste addition at 80 Ktoe, inorganic content in waste at 2%, leachate recirculation rate at 250 l/day and landfill age at 3 years. Further, inorganic content waste is found to be the most significant parameter for the multiple performance of the landfill. This study presents a novel approach to produce input parameters for power plants which may enhance their profitability and sustainability.
Advances in the greener synthesis of chromopyrimidine derivatives by a multicomponent tandem oxidation process
Authors: Ghamari Kargar Pouya , Bagherzade Ghodsieh
Published: November 2023

A hydrophilic cobalt/copper heterogeneous bimetallic catalyst named mTEG-CS-Co/Cu-Schiff-base/IL was successfully synthesized from chitosan polysaccharide. The new catalyst was investigated and confirmed using various techniques including FT-IR, FE-SEM, EDX-EDS, XRD, TEM, TGA, AFM, NMR and ICP. The catalyst exhibited powerful catalyst activity for the tandem one pot oxidative chromopyrimidine reaction from benzyl alcohols under mild conditions, utilizing air as a clean source in a green protocol. The catalyst was compatible with a wide range of benzyl alcohols, and aldehydes formed in situ, and bis-aldehydes synthesized were condensed with urea/4‑hydroxycumarin to provide favorable products in good yields for all derivatives (14 new derivatives). The presence of tri-ethylene glycol and imidazolium moieties with hydrophilic properties on the mTEG-CS-Co/Cu-Schiff-base/IL nanohybrid provides dispersion of the nanohybrid particles in water, leading to higher catalytic performance. Furthermore, the reaction exhibited several other notable features, including low catalyst loading, the ability to be recycled for up to 6 stages, high atom economy, a simple work procedure, short reaction time, utilization of an environmentally friendly nanohybrid, and the replacement of volatile and organic solvents with water solvent.
Red clays indicate sub-aerial exposure of the Rio Grande Rise during the Eocene volcanic episode
Authors: Srivastava Priyeshu , J. Murton Bramley , Sant’Anna Lucy Gomes , Florindo Fabio , Hassan Muhammad Bin , Taciro Mandacaru Guerra Julia , de Assis Janasi Valdecir , Jovane Luigi
Published: November 2023

Autonomous underwater vehicle (AUV) mapping of the western Rio Grande Rise (RGR), South Atlantic, and subsequent exploration and photography of horizontal lava flows exposed in near vertical, faulted escarpments, showed occurrences of red clays/weathered volcanic tops trapped between successive alkaline lava flows. These red clays indicate a hiatus in successive volcanic eruptions. Here, we report detailed mineralogical, geochemical, and rock magnetic characteristics of one such distinct red clay dredged from ~ 650 m water depth in the western RGR. The mineral constituents of the red clay are kaolinite, magnetite, oxidized magnetite (/maghemite), hematite, and goethite, with biogenic calcite and halite occupying voids or precipitated on the surface of the red clay. The chemical index of alteration (CIA) has a value of 93, showing that red clay is a product of extreme chemical weathering of the lava flows. The alkaline volcanic rocks recovered from nearby show an age of ~ 44 Ma, indicating an Eocene age for the volcanism. We show that the red clays are a product of sub-aerial chemical weathering of these Eocene volcanic rocks, in a warm-wet climate, before the thermal subsidence of the RGR to its modern-day bathymetric depth.
Analysis on the synergistic variation law of pile refreezing process and bearing capacity based on high-strain dynamic test method
Authors: Yu Dezhong , Cao Yang , Zhao Qianqian
Published: November 2023

The high-strain dynamic test method possesses the attributes of speed, efficiency, and environmentally-friendly, low-carbon characteristics. To study the reliability of the high-strain dynamic test method in detecting the bearing capacity of pile foundation in permafrost regions, 4 test piles, each with a length of 15 m and a diameter of 1.0 m, were poured based on the actual bridge construction project in the permafrost region of Daxing'an Mountains in China. Based on the temperature data between the piles and soil, the refreezing state of the pile foundation was comprehensively judged. Subsequently, the static method was employed to assess the friction resistance values and single pile bearing capacity of each soil layer on the pile side under different freezing states before and after the pile foundation refreezing. Building upon these findings, the restrictive parameters for soil elastic limit $$q_{(i)}$$

q

(
i
)

, soil resistance $$R_{U} (i)$$

R
U

(
i
)

and other parameters in the pile-soil model of high-strain dynamic test method are clarified. The test and analysis results indicate that under the condition that the ground temperature of frozen soil is about − 1.9 °C, the pile-soil refreezing takes about 120 days, and the pile-soil refreezing is a slow process; In CAPWAPC calculation program, after the values of soil parameters were constrained by the results of static-load test, the calculated curve is in satisfactory agreement with the measured curve, and the parameters of the pile-soil model are reliable, which can be used for the rapid detection of the ultimate bearing capacity of piles in permafrost regions; In the process of pile-soil refreezing, the change of temperature field affects the freezing strength between pile and soil, the process of pile-soil refreezing is positively correlated with the increase of pile foundation bearing capacity.
Comprehensive characterization of TGFB1 across hematological malignancies
Authors: Wang Cui-zhu , Zhang Zi-qi , Zhang Yan , Zheng Liang-feng , Liu Yang , Yan Ai-ting , Zhang Yuan-cui , Chang Qing-hua , Sha Suo , Xu Zi-jun
Published: November 2023

TGFB1, which encodes TGF-β1, a potent cytokine regulating varies cellular processes including immune responses. TGF-β1 plays context-dependent roles in cancers and is increasingly recognized as a therapeutic target to enhance immunotherapy responses. We comprehensively evaluated expression of TGFB1 and its clinical and biological effects across hematological malignancies. TGFB1 expression was first explored using data from the GTEx, CCLE, and TCGA databases. The expression and clinical significances of TGFB1 in hematological malignancies were analyzed using Hemap and our In Silico curated datasets. We also analyzed the relationship between TGFB1 with immune scores and immune cell infiltrations in Hemap. We further assessed the value of TGFB1 in predicting immunotherapy response using TIDE and real-world immunotherapy datasets. TGFB1 showed a hematologic-tissue-specific expression pattern both across normal tissues and cancer types. TGFB1 expression were broadly dysregulated in blood cancers and generally associated with adverse prognosis. TGFB1 expression were associated with distinct TME properties among different blood cancer types. In addition, TGFB1 expression was found to be a useful marker in predicting immunotherapy responses. Our results suggest that TGFB1 is broadly dysregulated in hematological malignancies. TGFB1 might regulate the immune microenvironment in a cancer-type-specific manner, which could be applied in the development of new targeted drugs for immunotherapy.
Surgical outcomes of acetabular fracture of elderly patients with superomedial dome impaction
Authors: Lim Eic Ju , Shon Hyun-Chul , Yang Jae-Young , Ahn Joosuk , Kim Jung Jae , Kim Ji Wan
Published: November 2023

This study aimed to investigate the outcomes of elderly acetabular fractures according to the reduction of impacted dome fragments. A retrospective cohort study was performed in two institutions. Fifty-four patients aged ≥ 60 years with acetabular fractures were enrolled. Data for dome impaction and postoperative reduction was collected. Patients were divided into the good reduction group (displacement ≤ 3 mm) and poor reduction group (displacement > 3 mm). Postoperative osteoarthritis (OA), Harris hip score (HHS), total hip arthroplasty conversion, good/poor outcomes were compared between the two groups. The good reduction group (N = 45) demonstrated a lower proportion of radiographic OA (18 vs. 77%, P = 0.001), higher HHS (82.1 vs. 68.6, P = 0.022), and higher proportion of good outcomes than the poor reduction group (N = 9) (89 vs. 22%, P < 0.001). In a subgroup analysis of the patients with dome impaction, the good reduction group had a higher proportion of good outcomes (80 vs. 20%, P = 0.031). On comparing within the good reduction group, dome impaction did not influence clinical outcomes. Elderly acetabular fractures demonstrated favorable outcomes when adequate reduction was achieved even with dome impaction. Well-reduced dome impaction could achieve satisfactory outcomes in elderly acetabular fractures.
Molecular and biological investigating of tea plant necrotic ring blotch virus as a worldwide threat
Authors: Esmaeilzadeh Fereshteh , Ghorbani Abozar , Koolivand Davoud
Published: November 2023

Tea plant necrotic ring blotch virus (TPNRBV) has emerged as a significant threat to tea plantations, primarily in China. Since 2020, similar symptoms have been observed in tea plants in northern Iran, raising concerns about the spread of this viral infection. In this study, we conducted an extensive investigation involving approximately 70 samples collected from both symptomatic and asymptomatic tea plants. Using reverse transcription-polymerase chain reaction with specially designed primers, we successfully amplified DNA fragments from 26 samples, confirming the presence of TPNRBV. Subsequent sequencing of these fragments revealed various segments of the TPNRBV genome. Our phylogenetic analysis revealed that the Iranian TPNRBV isolates formed a distinct sub-cluster alongside Chinese isolates, distinguishing them from Japanese isolates. These finding sheds light on the genetic diversity and relationships of TPNRBV across different regions. Additionally, we explored the potential modes of TPNRBV transmission. Mechanical transmission experiments confirmed the ability of the virus to infect Nicotiana rustica and Chenopodium quinoa seedlings, highlighting the risk of mechanical spread within tea plantations. Moreover, we investigated seed transmission and found evidence of TPNRBV in various parts of tea seeds, suggesting the possibility of seed-borne transmission. Overall, this comprehensive study enhances our understanding of the biological and molecular characteristics of TPNRBV, an emerging threat to global tea production. Our findings provide valuable insights into the virus’s transmission dynamics and genetic diversity, which are essential for developing effective management strategies to mitigate its impact on tea cultivation worldwide.
Absence of the primary cilia formation gene Talpid3 impairs muscle stem cell function
Authors: Martinez-Heredia Victor , Blackwell Danielle , Sebastian Sujith , Pearson Timothy , Mok Gi Fay , Mincarelli Laura , Utting Charlotte , Folkes Leighton , Poeschl Ernst , Macaulay Iain , Mayer Ulrike , Münsterberg Andrea
Published: November 2023

Skeletal muscle stem cells (MuSC) are crucial for tissue homoeostasis and repair after injury. Following activation, they proliferate to generate differentiating myoblasts. A proportion of cells self-renew, re-enter the MuSC niche under the basal lamina outside the myofiber and become quiescent. Quiescent MuSC have a primary cilium, which is disassembled upon cell cycle entry. Ex vivo experiments suggest cilia are important for MuSC self-renewal, however, their requirement for muscle regeneration in vivo remains poorly understood. Talpid3 (TA3) is essential for primary cilia formation and Hedgehog (Hh) signalling. Here we use tamoxifen-inducible conditional deletion of TA3 in MuSC (iSC-KO) and show that regeneration is impaired in response to cytotoxic injury. Depletion of MuSC after regeneration suggests impaired self-renewal, also consistent with an exacerbated phenotype in TA3iSC-KO mice after repeat injury. Single cell transcriptomics of MuSC progeny isolated from myofibers identifies components of several signalling pathways, which are deregulated in absence of TA3, including Hh and Wnt. Pharmacological activation of Wnt restores muscle regeneration, while purmorphamine, an activator of the Smoothened (Smo) co-receptor in the Hh pathway, has no effect. Together, our data show that TA3 and primary cilia are important for MuSC self-renewal and pharmacological treatment can efficiently restore muscle regeneration.
Projecting spatial interactions between global population and land use changes in the 21st century
Authors: Yang Di , Luan Wei-Xin , Zhang Xiaoling
Published: November 2023

Previous research on global urban land expansion has primarily focused on accommodating the growing population without adequately considering the trade-offs between urban land and ecological services. Consequently, it is important to investigate the effect of this expansion on the ecological service system, while also examining the potential trade-offs between population growth and available urban land. Here, we quantify how different global land expansion options contribute to reconciling global population changes and to compliance with the UN Sustainable Development Goal 11 on sustainable cities and human settlements. Using an integrated framework for projecting global land consumption with the trade-off strategy between global land expansion and population under shared socioeconomic pathways (SSPs), we aim to bridge the knowledge gap in this area. The results of our study suggest that implementing a trade-off strategy between global land expansion and population growth can successfully reduce the levels of global land consumption in the future. Under the SSP1 scenario, for instance, our findings indicate that implementing trade-off policies can significantly reduce land consumption while increasing carbon sinks and protecting the global ecological service system. Specifically, converting land to forest or grassland can help decrease land consumption by 8.07% by the end of the 21st century. These insights can be valuable in designing land use policies that incorporate data-based solutions and address the challenges of sustainable urban development while also accommodating population growth.
Asymmetric seafloor depth across the Juan de Fuca Ridge caused by lithospheric heating
Authors: Wu Mengyu , Ritzwoller Michael H.
Published: November 2023

Previous studies attribute asymmetries across the East Pacific Rise to horizontal temperature or pressure gradients in the deep asthenosphere caused by the Pacific Superswell, which, however, cannot explain asymmetries observed across the Juan de Fuca Ridge. Here, we provide seismic evidence that the asymmetric seafloor depth across the Juan de Fuca Ridge is primarily caused by thermal buoyancy due to lithospheric heating and thinning. Based on a seismic model generated from Rayleigh wave measurements, we demonstrate that the seafloor depth on the western flank of the ridge, which is shallower ( > 150 m) than the prediction from the plate age, agrees with the relatively younger apparent thermal age inferred from the seismic data, whereas the buoyancy of the deeper asthenosphere alone can only account for <25% of the rise. On the eastern flank, both plate age and apparent thermal age are consistent with observed seafloor depth.
Ag nanoparticle modified porous Si microspheres as high-performance anodes for Li-ion batteries
Authors: Pan Wenhao , Yang Changjiang , Zhou Lei , Cai Xiaolan , Wang Yankun , Tan Junhao , Chang Jun
Published: November 2023

A specially tailored porous Si microsphere, enhanced by Ag nanoparticles, is used in lithium-ion battery anodes to deliver superior cycle performance, rate performance, and a remarkably high initial Coulombic efficiency.
Recent progress of antipoisoning catalytic materials for high temperature proton exchange membrane fuel cells doped with phosphoric acid
Authors: Xue Dongping , Zhang Jia-Nan
Published: November 2023

The current challenges and opportunities faced by HT-PEMFCs are discussed, as well as possible future solutions. This review can provide guidance for the future development of high-performance HT-PEMFC catalysts.
Praxis der Sozialen Arbeit in der medizinischen Rehabilitation
– Entwicklung einer empirisch fundierten Programmtheorie
Authors: Knoop Tobias , Scheiblich Nadja , Dettmers Stephan , Meyer-Feil Thorsten
Published: November 2023

Ziel der Studie Sozialarbeiter*innen sind Teil des
interprofessionellen Reha-Teams. Gleichwohl findet sich kaum Evidenz für
ihre Leistungen, ebenso fehlt eine theoretisch anschlussfähige
Beschreibung ihrer Praxis. An dieser Stelle setzt das Projekt
„Sozialarbeiterische Wirkmechanismen in der medizinischen Rehabilitation
(SWIMMER)“ an und zielt auf die Entwicklung einer Programmtheorie der
Sozialen Arbeit in der medizinischen Rehabilitation.

Methodik In dem qualitativen Forschungsprojekt wurden in zehn
Reha-Einrichtungen Interviews mit Sozialarbeiter*innen und
Leitungskräften sowie teilnehmende Beobachtungen durchgeführt
und Beratungsgespräche aufgezeichnet. Sampling und Auswertung
orientierten sich an der Grounded Theory.

Ergebnisse In den Einrichtungen konnten 42 Interviews, 14
Beratungsgespräche sowie die Protokolle von ca. 140 h
begleiteter Praxis ausgewertet werden. Die fallbezogene Praxis der Sozialen
Arbeit kann mit den drei Kernkategorien Arbeitsformen (z. B.
Informations- und Antragsarbeit), Interaktionssettings (Austausch mit
Rehabilitand*innen, dem Reha-Team und externen Akteuren) und Aufgaben
der Sozialdienste (z. B. Entwicklung beruflicher Perspektiven
beruflicher/sozialer Teilhabe, finanzielle und soziale Sicherung)
beschrieben werden. Als zentrales Charakteristikum der Praxis konnte die
Ko-Produktion mit den Rehabilitand*innen herausgearbeitet werden. Die
Konsequenzen sozialarbeiterischer Praxis wurden in Output- und Outcome-Faktoren
differenziert. Erstere sind z. B. gestellte Anträge oder
genannte Optionen der beruflichen Rückkehr. Zentrale Outcomedimensionen
sind die Teilhabe bzw. eine Perspektive auf diese und das Wohlbefinden der
Rehabilitand*innen.

Schlussfolgerungen Die als Ergebnis des Projekts empirisch fundiert
entwickelten Hypothesen der dem Modell zugrundeliegenden Wirkmechanismen sollten
in weiteren Studien näher untersucht werden. Zusätzlich zu einem
Nutzen für die Praktiker*innen eignet sich das Modell zudem zur
Einordnung der Ergebnisse wissenschaftlicher Studien.
Flow Cytometry in the Diagnostic Laboratory Workup of Acute Lymphoblastic Leukemias
Authors: Sharma Praveen , Srinivasan Tharageswari , Mallik Nabhajit
Published: November 2023

Acute lymphoblastic leukemias (ALLs) are hematological neoplasms characterized by clonal proliferation of lymphoid blasts, which can be B- or T-cell type. Flow cytometric immunophenotyping is an integral component in establishing blast lineage during the diagnostic workup of ALLs, aiding in appropriate therapy, prognostication, and monitoring of the disease. The current review focuses on the utility of flow cytometry in the workup of ALLs, including the usefulness of various antibodies and pitfalls in diagnosis.
Flow Cytometric Ploidy Analysis in Acute Lymphoblastic Leukemia and Plasma Cell Myeloma
Authors: Bommannan Karthik
Published: November 2023

Identification of underlying cytogenetic (CG) aberrancies plays a significant role in risk stratification of hematological malignancies. These abnormalities can be due to aberrancies that affect the number or structure of chromosomes. Numerical chromosomal abnormalities are called aneuploidies, which result from either gain or loss of whole chromosomes. Ploidy assessment by CG is a laborious and less sensitive technique. With the aid of fluorescent nucleic acid binding dyes, the total DNA content and different phases of the cell cycle specific to any population of interest can be deciphered and analyzed by flow cytometry (FCM). DNA index (DI), a parameter derived by FCM DNA analysis, is equivalent to conventional CG-based ploidy assessment. In this study, the technical aspects and implications of FCM DNA assessment among patients diagnosed with acute lymphoblastic leukemia and plasma cell myeloma are discussed.
Exploring the effectiveness of fiscal decentralization in environmental expenditure based on the CO2 ecological footprint in urban China
Authors: Fang Guochang , Yang Kun , Chen Gang , Ren Xiaohang , Taghizadeh-Hesary Farhad
Published: November 2023

Under the fiscal decentralization of government environmental management, this paper investigates the relationship between local environmental protection expenditure (LEPE) and CO2 ecological footprint (CEF). Unlike conventional emissions-based greenhouse gas metrics, this research calculates per capita CEF for 253 Chinese cities, considering both carbon emissions and absorption. The dynamic spatial Durbin model demonstrates that LEPE not only reduces a city’s own CEF but also exerts a long-term influence on neighboring cities, signifying competitive dynamics among local governments in LEPE. This decentraliztion of environmental budget authority may yield adverse outcomes. Further analysis reveals an inverted U-shaped relationship between CEF and LEPE intensity, partly mirroring the environmental Kuznets curve. Different developmental stages should consider economic levels when allocating resources to environmental budgets. The low-carbon pilot policy strengthens LEPE, with varying effects across Chinese urban agglomerations, remaining consistent post-environmental protection tax introduction. These findings hold critical reference value for local policymakers aiming to collaboratively adjust market-oriented environmental policies.
Rich local knowledge despite high transience in an Arctic community experiencing rapid environmental change
Authors: Lennert Ann Eileen , van der Wal René , Zhang Jasmine , Hausner Vera Helene , Ancin Murguzur Francisco Javier , Miles Martin W.
Published: November 2023

Environmental monitoring and long-term research produce detailed understanding, but its collective effort does not add up to ‘the environment’ and therefore may be difficult to relate to. Local knowledge, by contrast, is multifaceted and relational and therefore can help ground and complement scientific knowledge to reach a more complete and holistic understanding of the environment and changes therein. Today’s societies, however, are increasingly fleeting, with mobility potentially undermining the opportunity to generate rich community knowledge. Here we perform a case study of High Arctic Svalbard, a climate change and environmental science hotspot, using a range of community science methods, including a Maptionnaire survey, focus groups, interviews and cognitive mapping. We show that rich local knowledge on Svalbard could indeed be gathered through community science methods, despite a high level of transience of the local population. These insights complement environmental monitoring and enhance its local relevance. Complex understanding of Svalbard’s ecosystems by the transient local community arose because of strong place attachment, enabling environmental knowledge generation during work and play. We conclude that transience does not necessarily prevent the generation of valuable local knowledge that can enrich and provide connection to scientific understanding of the environment.