bluuebunny/crossref_metadata_2025 huggingface dataset:
Ontology-based group assessment analytics framework for performances prediction in project-based collaborative learning
Authors: Hadyaoui Asma , Cheniti-Belcadhi Lilia
Published: September 2023

This article introduces an ontology-based framework for group assessment analytics that investigates the impact of intra-group interactions on group performance within the context of project-based collaborative learning (PBCL). Additionally, it aims to predict learners’ performance based on these interactions. The study involved 312 first-degree students specializing in transportation and technology engineering. The framework collects interaction data from discussion forums and chat rooms, conducts comprehensive data analysis, and constructs prediction models using supervised learning methods. The results unequivocally demonstrate that intra-group interactions significantly affect group performance in PBCL. The prediction model, with an accuracy metric of 0.92 and a final test score of 0.77, supports the credibility of the findings. Notably, the framework utilizes an ePortfolio specifically designed for group assessments, effectively managing both assessment and group data. This framework provides educators with a robust tool to assess group performance, identify areas requiring improvement, and contribute to shaping informed student learning outcomes. Furthermore, it empowers students by enabling them to receive feedback on their collaborative efforts, fostering enhanced interaction skills. These findings carry significant implications for the development and implementation of PBCL environments, offering educators valuable insights for evaluating student progress and making strategic decisions.
Expression of TXLNA in brain gliomas and its clinical significance: a bioinformatics analysis
Authors: Hu Bowen , Chen Desheng , Li Yang , Yu Shan , Kuang Liangwen , Ma Xinqi , Yang Qingsong , He Ke , Zhao Yan , Wang Guangzhi , Guo Mian
Published: September 2023

Background

To analyze the expression of TXLNA in brain gliomas and its clinical significance.

Methods

Gene Expression Profiling Interactive Analysis（GEPIA）and Chinese Glioma Genome Atlas（CGGA）databases were retrieved as the methods. To assess the disparity between TXLNA expression in glioma and normal brain tissue. The Kaplan-Meier survival curve was employed to preliminarily evaluate the survival curves of the high and low expression groups, this was done for investigate the correlation between TXLNA expression level and the survival and prognosis of glioma. A Cox proportional regression risk model of multivariate nature was employed to evaluate the elements impacting the survival and prognosis of glioma. Gene pool enrichment analysis（GSEA）was used to investigate the related function of TXLNA in glioma. A Pearson correlation test and co-expression analysis were employed to identify the genes most associated with TXLNA expression.

Result

The enrichment analysis results were observably enriched in signal pathways for instance the cell cycle and completion and coordination cascade pathways, and it is evident that high expression of TXLNA in gliomas is related to a poor survival and a bad patient prognosis, thus making it an independent prognostic factor for gliomas. Genes such as STK40 and R1MS1 are significantly correlated with TXLNA, playing a synergistic or antagonistic role.

Conclusions

The prognosis of GBM patients is strongly linked to the high expression of TXLNA, which may be a viable therapeutic target for curbing cancer progression and creating new immunotherapies for GBM.
Young adults’ sought gratifications from, and perceptions of food advertising by, social media influencers: a qualitative approach
Authors: Alhothali Ghada Talat , Aljefree Najlaa M.
Published: September 2023

Background

This study aims to explore young adults’ sought gratifications from social media influencers and whether they are exposed to food advertising by influencers. Further, it aims to understand how young individuals perceive food advertisements by social media influencers.

Methods

This qualitative study was conducted on 17 students from two public universities—King Abdul Aziz and Jeddah universities—located in the City of Jeddah, Saudi Arabia, using in-depth, face-to-face, and semi-structured interviews. The participants were active users of social media platforms who followed at least one influencer. Thematic analysis was used to analyse the data. The COREQ guidelines for reporting qualitative research (see Additional file 2) were followed when stating the findings.

Results

The findings reveal ten themes, that is, seven gratifications sought by young adults—broadening knowledge, perceived usefulness, self-improvement, boosting positivity, fostering morale, reinforcing inspiration, and passing time/enjoyment—and three themes (i.e. repeated, authentic, and unhealthy) that describe how Saudi young adults perceive food advertising.

Conclusion

This study contributes to social media influencer marketing by identifying the factors that motivate young consumers to follow influencers, and it elucidates the extent to which young adults are exposed to food marketing, adding to the body of literature on food advertising.
Unraveling the complexity: understanding the deconvolutions of RNA-seq data
Authors: Momeni Kavoos , Ghorbian Saeid , Ahmadpour Ehsan , Sharifi Rasoul
Published: September 2023

Deconvolution of RNA sequencing data is a computational method used to estimate the relative proportions of different cell types or subpopulations within a heterogeneous sample based on gene expression profiles. This technique is particularly useful in studies where the goal is to identify changes in gene expression that are specific to a particular cell type or subpopulation.

The deconvolution process involves using reference gene expression profiles from known cell types or subpopulations to infer the relative abundance of these cells within a mixed sample. This is typically done using linear regression or other statistical methods to model the observed gene expression data as a linear combination of the reference profiles.

Once the relative proportions of each cell type or subpopulation have been estimated, downstream analyses can be performed on each component separately, allowing for more precise identification of cell-type-specific changes in gene expression.

Overall, deconvolution of RNA sequencing data is a powerful tool for dissecting complex biological systems and identifying cell-type-specific molecular signatures that may be relevant for disease diagnosis and treatment.
Functional outcome and mortality prediction after decompressive craniectomy in patients with malignant middle cerebral artery infarction
Authors: Abouhashem Safwat , Bafaquh Mohammed , Assem Ahmed , Taha Mahmoud M. , ELSherif Mohammed , El-Atawy Shawkat , Hashem Maryam , Eldawoody Hany
Published: September 2023

Background

Although it is well known that performing decompressive craniectomy (DC) in cases of swollen middle cerebral artery infarction (SMCAI) improves patient outcomes, limited evidence presently exists on the likelihood of mortality and achieving functional outcome following DC. The aim of the present study was to identify the predictors of early in-hospital mortality and functional status six months after performing DC in a cohort of patients with SMCAI.

Material and methods

All patients that had suffered SMCAI and underwent DC were included in the study sample and their demographic information, along with clinical and radiological findings, and risk factors were recorded for further analyses, which were conducted using the commercial software STATA. Modified Rankin Scale score (mRS) served as an outcome measure at 6-month follow-up.

Results

DC was performed on 50 patients with SMCAI (72% of whom had left hemisphere infractions) aged 45.2 ± 10.2 years (range 24–67 years), 32 (64%) of whom were female and 18 (36%) were male. While the initial median Glasgow Coma Scale (GCS) score was 8 (range 4–13), clinical deterioration mostly occurred within the first five days, whereby DC was performed within 9 ± 7.2 h (range 2–36 h). Following surgery, 16 (32%) patients died while in hospital, whereas the remaining 34 were discharged after 135 days on average, and attended the 6-month follow-up, when the median mRS score of 3 (range 2–6) was recorded for this subsample.

Conclusions

Younger age, higher GCS score, presence of isochoric pupils, history of prior treatment (e.g., embolectomy or tissue plasminogen activator), and shorter interval between clinical deterioration and surgery are associated with a lower likelihood of mortality and a greater odd of a favorable functional outcome.
Hydromagnetic flow of micropolar nanofluids with co-effects of thermal radiation and chemical reaction over an inclined permeable stretching surface
Authors: Ajala O. A. , Adegbite P.
Published: September 2023

Background

Many investigations have been conducted by researchers across the globe to examine the behavior of fluids with respect to the influence of some constituent parameters and novel results have been obtained. However, the combined effect of thermal radiation and chemical reaction on micropolar nanofluid flow over an inclined stretching surface has not been well elucidated. This article, therefore, employed the mathematical model of Buongiorno for hydromagnetic micropolar nanofluids to study the effect of thermal radiation and chemical reaction on such fluids. The model examined the influence of thermophoresis, Brownian motion and the angle of inclination to the stretching surface on the fluid flow. The set of governing equations were transformed into ordinary differential equations using some similarity transformations and then numerically simplified through Chebyshev collocation method on MATHEMATICA software.

Results

The graphs thus derived were used to interpret the effect of some physical parameters on the fluid flow. It was observed among other results obtained, that thermal radiation, Brownian motion and thermophoresis enhanced the temperature profile of the flow while the inclination angle and chemical reaction declined the velocity and concentration, respectively.

Conclusions

These parameters tested on the various profiles proved observably effective on micropolar nanofluids and should be considered whenever improvement or decrease in the profiles are needed.
Nasal columella reconstruction using philtrum advancement flap: a case report of treatment of nasal stenosis
Authors: Adamu Auwal , Kirfi Abdullahi Musa , Shofoluwe Nurudeen Adebola , Shuaibu Iliyasu Yunusa , Nwaorgu Onyekwere George B.
Published: September 2023

Background

Nasal columella reconstruction is a challenging procedure, and the main goal is to maintain function as well as a satisfactory aesthetic outcome. Several surgical techniques have been described for the reconstruction of nasal columella. However, there is a paucity of literature on these techniques in our environment, and the use of superiorly based philtrum advancement flaps is extremely rare in African literature.

Case presentation

A 60-year-old man presented with nasal obstruction and nasal deformity following facial trauma 6 months prior to presentation. Examination revealed bilateral stenosed nasal cavities and a very short columella with a healed nasal scar. The diagnosis of nasal stenosis was made. Intra-operatively, a superiorly based philtrum advancement flap was designed and elevated, granulation tissues in the nasal cavities were excised, the septum was repositioned, the base of the flap was sutured at the midline of the floor of the nose, and the donor site was approximated. A bilateral nasal stent was applied for 4 weeks. Postoperatively, the recipient and donor sites healed completely with an aesthetically acceptable appearance, and the patient was satisfied with the outcome.

Conclusion

Nasal columellar reconstruction is a complex procedure. The superiorly based philtrum advancement flap is a simple and aesthetically acceptable method of treating nasal stenosis. This method demonstrated an adequate nasal airway and a good cosmetic appearance.
A card-sorting tool to measure expert versus novice thinking in scientific research
Authors: Cole Megan F. , Britton Clarke O. , Roberts Denver , Rubin Peter , Shin Hannah D. , Watson Yassin R. , Harrison Colin
Published: September 2023

Using a card-sorting task it was shown that expert and novice thinking is different when conceptualizing research. Experts sort more based on deep features of research approach than novices. This card-sorting task can be useful for analyzing student growth in research approach and design.
Premonition of Death
Authors: Bramati Patricia S. , Aldana Grecia , Bruera Eduardo
Published: September 2023

We described and analyzed death premonitions after a patient accurately announced her own imminent unexpected death.
Efficacy of low-dose lung radiotherapy in the management of COVID-19 patients: a randomised, open-label study
Authors: Dinakar Kootala , Jakka Mohan Krishna , Vemannagari Pavan Kumar Reddy , Mohan Alladi , Subramanian Bala Venkat , Bodagala Vijayalakshmi Devi , Bhuma Vengamma , Das Pranabandhu , Bonala Sreenivasa Rao , Vutukuru Venkatarami Reddy
Published: September 2023

Objective

Evaluate role of low-dose radiotherapy (LDRT) in COVID-19 pneumonia.

Methods

Sixty-five patients 40 years or older tested positive for COVID-19 reverse transcriptase-polymerase chain reaction with mild to moderate acute respiratory distress syndrome (ARDS), were randomised 1:1, from 4 June 2021, to either best standard of care (control arm) according to the Indian Council of Medical Research guidelines or a single dose of LDRT (LDRT-0.5Gy) to both lungs along with best standard of care (experimental arm). The primary outcome was either progression to severe disease (PaO2/FiO2 ratio <100 mmHg) within 28 days of randomisation or all-cause mortality at 28 days. If the primary outcome could have been prevented, it was considered “favourable”; if not, it was considered “unfavourable.”

Results

Thirty-three patients were allocated to experimental arm, 32 to control arm. An intention to treat analysis was performed. Unfavourable outcome was seen in 5 (15.2%) patients in experimental arm, vs , 12 (37.5%) patients in control arm, odds of an unfavourable outcome in experimental arm were 0.3, 95% CI 0.09–0.97; two-sided p = 0.04. Four and five patients died in experimental and control arm, respectively. No radiation-induced toxicity was observed.

Conclusion

LDRT reduced the number of patients with unfavourable outcome at 28 days.

Advances in knowledge

One of the few randomised studies showing reduced unfavourable outcome in mild to moderate ARDS COVID-19 patients receiving LDRT.

CTRI/2021/06/034001, Clinical Trials Registry - India (ICMR-NIMS)
An MR-based radiomics nomogram including information from the peritumoral region to predict deep myometrial invasion in stage I endometrioid adenocarcinoma: a preliminary study
Authors: Yan Bin , Zhao Tingting , Li Zhihao , Ren Jialiang , Zhang Yuchen
Published: September 2023

Objective:

To develop and validate an MR-based radiomics nomogram combining different imaging sequences (ADC mapping and T2 weighted imaging (T2WI)), different tumor regions (combined intra- and peritumoral regions), and different parameters (clinical features, tumor morphological features, and radiomics features) while considering different MR field strengths in predicting deep myometrial invasion (MI) in Stage I endometrioid adenocarcinoma (EEA).

Methods:

A total of 202 patients were retrospectively analyzed and divided into two cohorts (training cohort, 1.5 T MR, n = 131; validation cohort, 3.0 T MR, n = 71). Axial ADC mapping and T2WI were conducted. Radiomics features were extracted from intra- and peritumoral regions. Least absolute shrinkage and selection operator regression, univariate analysis, and multivariate logistic regression were used to select radiomics features and tumor morphological and clinical parameters. The area under the receiver operator characteristic curve (AUC) was calculated to evaluate the performance of the prediction model and radiomics nomogram.

Results:

Ten radiomics features, 4 morphological parameters and 1 clinical characteristic were selected. The radiomics nomogram achieved good discrimination between the superficial and deep MI cohorts. The AUC was 0.927 (95% confidence interval [CI]: 0.865, 0.967) in the training cohort and 0.921 (95% CI: 0.872, 0.948) in the validation cohort. The specificity and sensitivity were 92.0 and 78.9% in the training cohort and 83.0 and 77.8% in the validation cohort, respectively.

Conclusion:

The radiomics nomogram showed good performance in predicting the depth of MI in Stage I EEA before surgery and might be useful for surgical patient management.

Advances in knowledge:

An MR-based radiomics nomogram was useful for predicting deep MI in Stage I EEA patients (AUCtrain = 0.927, AUCvalidation = 0.921). The intra- and peritumoral radiomics features complemented each other. The nomogram was developed and validated with different MR field strengths, suggesting that the model demonstrates good generalizability.
Potential benefits of photon counting detector computed tomography in pediatric imaging
Authors: Horst Kelly K , Yu Lifeng , McCollough Cynthia H , Esquivel Andrea , Thorne Jamison E , Rajiah Prabhakar Shanta , Baffour Francis , Hull Nathan C , Weber Nikkole M , Thacker Paul G , Thomas Kristen B , Binkovitz Larry A , Guerin Julie B , Fletcher Joel G
Published: September 2023

Photon counting detector (PCD) CT represents the newest advance in CT technology, with improved radiation dose efficiency, increased spatial resolution, inherent spectral imaging capabilities, and the ability to eliminate electronic noise. Its design fundamentally differs from conventional energy integrating detector CT because photons are directly converted to electrical signal in a single step. Rather than converting X-rays to visible light and having an output signal that is a summation of energies, PCD directly counts each photon and records its individual energy information. The current commercially available PCD-CT utilizes a dual-source CT geometry, which allows 66 ms cardiac temporal resolution and high-pitch (up to 3.2) scanning. This can greatly benefit pediatric patients by facilitating high quality fast scanning to allow sedation-free imaging. The energy-resolving nature of the utilized PCDs allows “always-on” dual-energy imaging capabilities, such as the creation of virtual monoenergetic, virtual non-contrast, virtual non-calcium, and other material-specific images. These features may be combined with high-resolution imaging, made possible by the decreased size of individual detector elements and the absence of interelement septa. This work reviews the foundational concepts associated with PCD-CT and presents examples to highlight the benefits of PCD-CT in the pediatric population.
Imaging prediction of KRAS mutation in patients with rectal cancer through deep metric learning using pretreatment [18F]Fluorodeoxyglucose positron emission tomography/computed tomography
Authors: Wu Kuo-Chen , Chen Shang-Wen , Hsieh Te-Chun , Yen Kuo-Yang , Chang Chao-Jen , Kuo Yu-Chieh , Hsu Yu-Ju , Chang Ruey-Feng , Kao Chia-Hung
Published: September 2023

Objectives:

To predict KRAS mutation in rectal cancer (RC) through computer vision of [18F]fluorodeoxyglucose (18F-FDG) positron emission tomography (PET)/computed tomography (CT) by using metric learning (ML).

Methods:

This study included 160 patients with RC who had undergone preoperative PET/CT. KRAS mutation was identified through polymerase chain reaction analysis. This model combined ML with the deep-learning framework to analyze PET data with or without CT images. The Batch Balance Wrapper framework and K-fold cross-validation were employed during the learning process. A receiver operating characteristic (ROC) curve analysis was performed to assess the model’s predictive performance.

Results:

Genetic alterations in KRAS were identified in 82 (51%) tumors. Both PET and CT images were used, and the proposed model had an area under the ROC curve of 0.836 for its ability to predict a mutation status. The sensitivity, specificity, and accuracy were 75.3%, 79.3%, and 77.5%, respectively. When PET images alone were used, the area under the curve was 0.817, whereas the sensitivity, specificity, and accuracy were 73.2%, 79.6%, and 76.2%, respectively.

Conclusions:

The ML model presented herein revealed that baseline 18F-FDG PET/CT images could provide supplemental information to determine KRAS mutation in RC. Additional studies are required to maximize the predictive accuracy.

Advances in knowledge

The results of the ML model presented herein indicate that baseline 18F-FDG PET/CT images could provide supplemental information for determining KRAS mutation in RC. The predictive accuracy of the model was 77.5% when both image types were used and 76.2% when PET images alone were used. Additional studies are required to maximize the predictive accuracy.
Sense and non-sense of imaging in the era of organ preservation for rectal cancer
Authors: Ou Xinde , van der Reijd Denise J , Lambregts Doenja MJ , Grotenhuis Brechtje A , van Triest Baukelien , Beets Geerard L , Beets-Tan Regina GH , Maas Monique
Published: September 2023

This review summarizes the current applications and benefits of imaging modalities for organ preservation in the treatment of rectal cancer. The concept of organ preservation in the treatment of rectal cancer has revolutionized the way rectal cancer is managed. Initially, organ preservation was limited to patients with locally advanced rectal cancer who needed neoadjuvant therapy to reduce tumor size before surgery and achieved complete response. However, neoadjuvant therapy is now increasingly utilized for smaller and less aggressive tumors to achieve primary organ preservation. Additionally, more intensive neoadjuvant strategies are employed to improve complete response rates and increase the chances of successful organ preservation. The selection of patients for organ preservation is a critical component of treatment, and imaging techniques such as digital rectal exam, endoscopy, and MRI are commonly used for this purpose. In this review, we provide an overview of what imaging modalities should be chosen and how they can aid in the selection and follow-up of patients undergoing organ-preserving strategies.
Predicting resection margin status of pancreatic neuroendocrine tumors on CT: performance of NCCN resectability criteria
Authors: Kim Dong Hwan , Kim Bohyun , Chung Dong Jin , Kim Kyung Ah , Lee Su Lim , Choi Moon Hyung , Kim Hokun , Rha Sung Eun
Published: September 2023

Objective

To test the performance of the National Comprehensive Cancer Network (NCCN) CT resectability criteria for predicting the surgical margin status of pancreatic neuroendocrine tumor (PNET) and to identify factors associated with margin-positive resection.

Methods

Eighty patients with pre-operative CT and upfront surgery were retrospectively enrolled. Two radiologists assessed the CT resectability (resectable [R], borderline resectable [BR], unresectable [UR]) of the PNET according to NCCN criteria. Logistic regression was used to identify factors associated with resection margin status. κ statistics were used to evaluate interreader agreements. Kaplan–Meier method with log-rank test was used to estimate and compare recurrence-free survival (RFS).

Results

Forty-five patients (56.2%) received R0 resection and 35 (43.8%) received R1 or R2 resection. R0 resection rates were 63.6–64.2%, 20.0–33.3%, and 0% for R, BR, and UR diseases, respectively (all p ≤ 0.002), with a good interreader agreement (κ, 0.74). Tumor size (<2 cm, 2–4 cm, and >4 cm; odds ratio (OR), 9.042–18.110; all p ≤ 0.007) and NCCN BR/UR diseases (OR, 5.918; p = 0.032) were predictors for R1 or R2 resection. The R0 resection rate was 91.7% for R disease <2 cm and decreased for larger R disease. R0 resection and smaller tumor size in R disease improved RFS.

Conclusion

NCCN resectability criteria can stratify patients with PNET into distinct groups of R0 resectability. Adding tumor size to R disease substantially improves the prediction of R0 resection, especially for PNETs <2 cm.

Advances in knowledge:

Tumor size and radiologic resectability independently predicted margin status of PNETs.
Medical imaging applied to heritage
Authors: Gibson Adam P
Published: September 2023

The use of imaging has transformed the study of cultural heritage artefacts in the same way that medical imaging has transformed medicine. X-ray-based techniques are common in both medical and heritage imaging. Optical imaging, including scientific photography and spectral imaging techniques, is also common in both domains. Some common medical imaging methods such as ultrasound and MRI have not yet found routine application in heritage, whereas other methods such as imaging with charged and uncharged particles and 3D surface imaging are more common in heritage. Here, we review the field of heritage imaging from the point of view of medical imaging and include some classic challenges of heritage imaging such as reading the text on burnt scrolls, identifying underdrawings in paintings, and CT scanning of mummies, an ancient calculating device and sealed documents. We show how hyperspectral imaging can offer insight into the drawing techniques of Leonardo da Vinci and explain how laparoscopy has identified the method of construction of a 500-year-old pop-up anatomical text book.
Znf598-mediated Rps10/eS10 ubiquitination contributes to the ribosome ubiquitination dynamics during zebrafish development
Authors: Ugajin Nozomi , Imami Koshi , Takada Hiraku , Ishihama Yasushi , Chiba Shinobu , Mishima Yuichiro
Published: September 2023

The ribosome is a translational apparatus that comprises about 80 ribosomal proteins and four rRNAs. Recent studies reported that ribosome ubiquitination is crucial for translational regulation and ribosome-associated quality control (RQC). However, little is known about the dynamics of ribosome ubiquitination under complex biological processes of multicellular organisms. To explore ribosome ubiquitination during animal development, we generated a zebrafish strain that expresses a FLAG-tagged ribosomal protein Rpl36/eL36 from its endogenous locus. We examined ribosome ubiquitination during zebrafish development by combining affinity purification of ribosomes fromrpl36-FLAG zebrafish embryos with immunoblotting analysis. Our findings showed that the ubiquitination of ribosomal proteins dynamically changed as development proceeded. We also showed that during zebrafish development, the ribosome was ubiquitinated by Znf598, an E3 ubiquitin ligase that activates RQC. Ribosomal protein Rps10/eS10 was found to be a key ubiquitinated protein during development. Furthermore, we showed that Rps10/eS10 ubiquitination-site mutations reduced the overall ubiquitination pattern of the ribosome. These results demonstrate the complexity and dynamics of ribosome ubiquitination during zebrafish development.
Effect of Kinesiotape Application on Knee Joint on Gait
Kinematics in High Heels
Authors: Guner Senem , Alsancak Serap
Published: September 2023

Abstract: Today, millions of women wear high-heeled shoes daily, and although it has been
suggested that the use of high-heeled (HH) shoes leads to an increased incidence of osteoarthritis,
back pain, and deterioration of posture. The study aimed to investigate the kinetic and kinematic
analysis in the lower extremities while walking on high-heeled shoes and compared kinesiotape
application on knee joints with HH shoes. Methods: A three-dimensional quantitative gait
evaluation was performed without tape and with wear HH shoes, with kinesio taping application
on the knee. Twenty-four healthy females (age, 21.6 ± 0.7 years; height, 1.64 ± 4.2 cm; body mass, 57
± 3.9 kg) participated in the study. Spatiotemporal parameters cadence and walking speed were
significantly different among the trials. Results: Knee and hip joint sagittal plane range of motion
were different with kinesin taping applications While knee joint total excursion (ROM) was 57,5±8.7
degrees with HH shoes, it was decreased to 54.05±5.8 tape application walking HH shoes. Knee
external flexion moment during the early stance phase decreased significantly in kinesin taping
with HH shoes. Conclusion: These findings showed that Kinesio taping application on quadriceps
femoris muscles affected the stance phase of the gait cycle and reduced knee joint flexion degree
and knee flexion moments while walking with HH shoes. Tape application may be an option to
reduce the negative effect of wearing high-heeled shoes on the knee while walking, or to reduce
knee pain, to provide support for knee deformities.
Multidisciplinary non-pharmacological treatments with effects on pain modulation and functioning in spondyloarthropathies – a systematic review
Authors: Ungureanu Adelina Elena , Stanciu Liliana-Elena , Uzun Andreea-Bianca , Gheorghe Emma , Pazara Loredana , Miclaus Steliana-Roxana , Ciortea Viorela-Mihaela , Suceveanu Andra-Iulia , Iliescu Madalina Gabriela
Published: September 2023

Abstract: Treatment for chronic rheumatic diseases, included various modalities for pain management and for functioning modulation, has the main gole to increase the quality of life and to improve also the activities of daily living. Seronegative spondyloarthropathies (SpA) are a group of
rheumatologic disorders that include ankylosing spondylitis, psoriatic arthritis, entheropatic SpA,
reactive arthritis and undifferentiated SpA. Treatment methods include clasically pharmacological
modalities. Physical therapy should also be highlighted as being part of the treatment. Balneotherapy and spa therapy are increasingly taken into account in evidence-based treatment guidelines for
multiple rheumatic diseases, for specific effects on functional parameters and also for the involvement in cartilage regeneration. Balneotherapy is universally defined as the treatment method which
uses bathing in thermal and mineral waters. Other balneological treatments include peloidotherapy, balneological gases and therapeutic waters in various forms of bathing, inhalation or drinking.
Spa therapy comprises complementary and alternative treatment modalities including balneotherapy, hydrotherapy, exercises, and massage therapy. This systematic literature review aims to highlight the effects of balneotherapy in spondylarthropathies. The review is based on the
internationally accepted method, the “PRISMA” methodology- “Preferred Reporting Items for Systematic Reviews and Meta-Analysis”.
The Role of Biomarkers in Elite Sports
Authors: Anghel Lucreția , Gurau Tudor Vladimir , Gurau Gabriela , Mușat Carmina Liana , Voinescu Doina Carina , Onu Ilie , Cordun Mariana , Codreanu Corneliu-Mircea , Iordan Daniel Andrei
Published: September 2023

Biomarkers have emerged as valuable tools in the realm of elite sports, providing objective measures of athletes' physiological responses and potential for performance optimization.
This article review delves into the significance and implications of biomarkers in elite sports, emphasizing their crucial role in supporting athletes' training, recovery, and overall success. The integration of biomarkers offers unprecedented opportunities for evidence-based decisions, personalized strategies, and injury prevention, revolutionizing the landscape of elite sports. Through comprehensive literature review and analysis, this article highlights the tremendous promise of biomarkers in optimizing athletic performance while also addressing the ethical considerations surrounding their implementation. As research continues to advance, biomarkers are poised to reshape
the future of elite sports, enhancing performance and paving the way for the next generation of
sporting legends.
Pandemic Pedagogy: Perception of Nursing students’: A cross-sectional study
Authors: D'Souza Prima Jenevive Jyothi , Assariparambil Anil Raj , Muthamilselvi G , Joseph Veena M , George Linu Sara
Published: September 2023

Coronavirus disease 2019 pandemic impacted across the globe disrupting all sectors including the higher education universities. Nursing institutions faced various challenges due to the pandemic restrictions, of which the abrupt shift of implementing the curriculum to online mode posed a major challenge to both the teachers and the students. To assess nursing students' perception of pandemic pedagogy and the challenges faced in remote teaching-learning, this cross-sectional survey was conducted among 982 undergraduate nursing students from three Deemed to be University nursing institutions of Southern India. Institutional Ethics Committee approval (IEC 444/2020), permission from the heads of the institutions and study participant’s consent was obtained. Data was collected using an online survey questionnaire which had three domains, including student-related (19 items), teacher-related(5 items), and physical learning environment-related factors (11 items).  The reliability was established using Cronbach’s Alpha (0.86). Explored the favouring, hindering factors and challenges faced during the emergency remote instruction with open-ended items. The overall mean score of perceptions on pandemic pedagogy was 89.03±10.03. Sixty-three percent of students had a total perception score above 87 which indicates that they preferred remote learning (synchronous) during the pandemic whereas 45% preferred face-to-face classes. There was a significant difference in the total perception scores and the years of study( F (3, 978) = 4.96, p = 0.002). The factors favouring remote learning were, an opportunity to view the recorded classes even after the live classes’ (n=165), and ‘more time to spend for learning activities’ (n=152). Factors that hindered the learning or the challenges faced were poor network connectivity (n=451), and lack of opportunity for group study  (n=326). Students favoured remote learning during the pandemic; however, there were several challenges. The educational institutions need to prepare themselves to overcome this and focus on a blended learning curriculum.
Metabolic disorders in patients with post-COVID-19 Tuberculosis: A Peruvian unicentric experience
Authors: Cruz-Gonzales Gloria , Hurtado-Concha Aristides , Lezama-Cotrina Irene , Fernández-Rengifo Wherther , Espinoza-Palomino Adrian , Cruz-Gonzales William , Cornejo-Alvites María , Rojas-Zumaran Víctor , Walttuoni-Picón Eder
Published: September 2023

Background: During the COVID-19 pandemic, the diagnosis, monitoring, and prevention of many significant pathologies began to be ignored, tuberculosis (TB) being one of these pathologies. The objective was to determine metabolic disorders and their association with TB stages in post-COVID-19 TB patients from the Félix Torrealva Gutiérrez Hospital in Ica, Peru. Methods: The research was observational, cross-sectional, and descriptive-correlational. The study was carried out on 80 patients diagnosed with post-COVID-19 tuberculosis. A questionnaire was used to collect the sociodemographic characteristics and the metabolites analyzed were glucose, lipid profile, and hepatic profile. Results: Among the 80 patients, a mean age of 56.6 years was observed and 52.5% were male. The presence of sensitive tuberculosis (56.3%), multiresistant tuberculosis (15%), and recurrent tuberculosis (28.7%) with 5.94 months of treatment was found. Alterations were found in the concentration of glucose (36.3%), total cholesterol (31.3%), triglycerides (52.5%), HDL (52.5%), LDL (53.8%), albumin (32.5%), total bilirubin (46.3%), direct bilirubin (5.0%), TGO (30.0%), TGP (56.3%), alkaline phosphatase (50.0%), GGTP (46.3%) and total protein (22.5%). TB stage was significantly associated with sex (p=0.011), treatment time (p˂0.001) and total cholesterol (p=0.021). Conclusions: There are post-COVID-19 metabolic disorders in patients with tuberculosis at the Félix Torrealva Gutiérrez Hospital in Ica, Peru.
Arterial blood analysis of healthy residents in Huamachuco, Peru (3,164 m): a cross-sectional study
Authors: Bardales-Zuta Victor H. , Fernández-Rodríguez Lissett J. , Romero-Goicochea Cecilia
Published: September 2023

Background: Given that arterial blood gas is affected by altitude and ethnicity, establishing reliable reference standards for these values requires analysis of arterial blood at different elevations and locations. Our objective was to measure the arterial blood gases of healthy young volunteers in Huamachuco, Peru, at 3,164 m above sea level. This is likely the first study of arterial blood gas analysis of healthy Northern Peruvians living at high altitude.

Methods: Healthy residents of Huamachuco were recruited for this cross-sectional convenience sample study and arterial blood was drawn by standard procedures. People with obesity, diabetes, high levels of physical activity and a history of using selected substances were excluded. The samples were analyzed on-site in less than 15 minutes using a Stat Profile Prime CCS analyzer (Nova Biomedical).

Results: Data from 46 participants (17 male, 29 female) were included in the study. The median values for arterial blood pH, oxygen, carbon dioxide, ionized calcium, glucose, lactate, hematocrit, oxygen saturation, and bicarbonate were 7.42, 9.3 kPa (70 mmHg), 4.5 kPa (33.5 mmHg), 1.04 mM, 5.19 mM, 1.8 mM, 50 %, 94 %, and 21.6 mM, respectively. We also found a lower prevalence of diabetes among highlanders compared to the Peruvian population.

Conclusions: The results determined here were comparable to other results determined at different altitudes in the Americas, although arterial blood oxygen was slightly higher than predicted. These results suggest a pattern of adaptations similar to those seen among Andean high-altitude natives.
Access to health services and its influence on adherence to treatment of arterial hypertension during the COVID-19 pandemic in a Hospital in Callao, Peru: A cross-sectional study
Authors: Rivera-Lozada Oriana , Rivera-Lozada Isabel Cristina , Bonilla-Asalde Cesar Antonio
Published: September 2023

Background: Access to health services compromises therapeutic adherence in patients with arterial hypertension (HTN), which is a risk factor for cardiovascular disease and premature death. The aim of the research is to determine the influence of access to health services on adherence to antihypertensive treatment during the COVID-19 pandemic. 

Methods: We included a cross-sectional analytical study. A survey was applied to 241 hypertensive patients at the Daniel Alcides Carrión Hospital, Callao-Peru. Data were analyzed using SPSS software. Absolute and relative frequencies were reported and the chi-square test was applied with a statistical significance level of p<0.05. In addition, multiple logistic regression analysis was performed using the Stepwise method. 

Results: Our results show that non-adherence to treatment is associated with health expenses (ORa: 1.9 CI 95% 1.7-2.2), not receiving care due to lack of a doctor (ORa: 2.8 CI 95% 1.5-3.2), having difficulty with schedules (ORa: 3.7 CI 95% 2. 3-5.5), fear of receiving care at the hospital (ORa: 4.5 CI 95 % 2.7-6.8), trust in health personnel (ORa: 7.5 CI 95% 2.3-10.5) and considering that the physician does not have enough knowledge (ORa: 3.1 CI 95% 2.4-7.8).  

Conclusion: Therapeutic adherence was associated with physician availability for care, difficulty with schedules, fear of being seen in the hospital, trust in health personnel, and waiting time.
Factors Affecting the Performance of Infection Control of Multi-drug Resistant Organisms in Intensive Care Unit Nurses of General Hospitals based on the Theory of Planned Behavior: The Mediating Effect of Intention
Authors: Kim Nam-Sook , Choi So-Eun
Published: September 2023

Purpose: The purpose of this study is to analyze the factors that affect the performance of infection control of multidrug-resistant organisms (MDROs) by nurses in intensive care units (ICU) in general hospitals. Methods: Participants were 105 ICU nurses from 6 general hospitals. The questions for the survey performed were based on the theory of planned behavior, such as attitude towards infection control of MDROs, subjective norms, perceived behavioral control, intention, and performance. Results: In the relationship between subjective norms towards infection control of MDROs and performance, intention showed a significant complete mediating effect; and in the relationship between perceived behavioral control and performance, intention showed a partial mediating effect. The attitude towards infection control of MDROs was excluded from the mediating effect verification because there was no significant correlation between intention and performance. Conclusion: The results of this study suggest that department atmosphere and perceived behavior control promotion programs should be developed to enhance subjective norms in order to promote the performance of infection control of MDROs.
Gender Differences in Older Adults’ Muscle Strength and Depressive Symptoms: A Relationship Mediated Through Perceived Stress
Authors: Kang Gyeong A , Shin Jihye , Yoon Ju Young
Published: September 2023

Purpose: Preventing the effects of physical vulnerability is a practical approach to improving older adults’ depressive symptoms. This study aims to examine the relationship between gender differences related to muscle strength and depressive symptoms mediated by perceived stress. Methods: In this cross-sectional study, data from 2,705 older adults (65 years old or older) from the Korea National Health and Nutrition Examination Survey VII 2016 and 2018 were analyzed. The moderated mediation model was developed; the outcome, independent, mediation, and moderated mediation variables in the literature-based research model were depressive symptoms, muscle strength, perceived stress, and gender, respectively. Results: Perceived stress had a mediating effect on the relationship between muscle strength and depressive symptoms. The indirect effect of muscle strength on depressive symptoms mediated by perceived stress was β = -.02 (95% CI:-0.03~-0.01). The moderated mediation model demonstrated that the interaction term of handgrip strength and gender negatively affected perceived stress, which indicated that gender moderated the mediating model of perceived stress on the association of muscle strength and depressive symptoms (β = -.01, p <.05). The conditional indirect effect model was insignificant in the male group (β = -.00, 95% CI:-0.01~0.01) but significant in the female group (β = -.01, 95% CI: -0.02~0.00). Conclusions: Perceived stress mediated the relationship between muscle strength and depressive symptoms. However, the effect differed by gender. A stress-mediated depressive symptoms intervention program for older adults should be developed to consider women’s needs.
A Unified Theory of Robust and Distributionally Robust Optimization via the Primal-Worst-Equals-Dual-Best Principle
Authors: Zhen Jianzhe , Kuhn Daniel , Wiesemann Wolfram
Published: September 2023

A Primal-Worst-Equals-Dual-Best Perspective on Robust and Distributionally Robust Optimization

In the paper “A Unified Theory of Robust and Distributionally Robust Optimization via the Primal-Worst-Equals-Dual-Best Principle,” Jianzhe Zhen, Daniel Kuhn, and Wolfram Wiesemann develop a generalized “primal-worst-equals-dual-best” principle that establishes strong duality between semi-infinite primal worst and nonconvex dual best formulations of robust and distributionally robust nonlinear optimization problems. Their theory offers an alternative characterization of (distributionally) robust optimization problems that bypasses the need to mobilize the machinery of abstract semi-infinite duality theory. The paper will be of interest to researchers and practitioners in the field of optimization under uncertainty.
Spontaneous intracranial hypotension complicated by a cerebral venous thrombosis following an mRNA COVID-19 vaccination: coincidence vs cause?
Authors: Pandey Anoop Kumar , Rooeintan Taleb
Published: September 2023

Spontaneous intracranial hypotension (SIH) is a rare cause of persistent headache, particularly among young and middle-aged people. A potentially life-threatening complication of SIH is a cerebral venous thrombosis (CVT). The authors present a case in which a patient presented with SIH complicated by CVT one week after receiving a booster dose of mRNA COVID-19 vaccine. According to our literature review, this is the first such case report.
Efficacy of transcranial magnetic stimulation in the treatment of alcohol dependence - a review article
Authors: Rak Mikołaj , Danek Michał , Dróżdż Wiktor
Published: September 2023

Introduction: Alcohol addiction is a common health problem with many negative consequences. Due to the unsatisfactory results of existing treatment, research is being undertaken into new forms of therapy. One such method is transcranial magnetic stimulation. This technique involves applying a magnetic field to the central nervous system. Successive magnetic pulses are delivered at a specific frequency causing neurons depolarization. Such repetitive exposure allows for long-term modulation of cortical excitability, and thus can lead to specific clinical effects. This paper discusses scientific reports about the treatment of alcohol dependence using transcranial magnetic stimulation (both papers on conventional repetitive transcranial magnetic stimulation, theta burst stimulation and deep transcranial magnetic stimulation are included).
Material and methods: Based on the search of the PubMed and Science Direct bibliographic databases, 12 studies published in the years 2010-2022 were selected. The results were tabulated to clearly compare differences in the parameters of stimulation, its location, as well as the effectiveness of the intervention used.
Results: The results of selected studies were compared. Differences in methodology were pointed out and the problem of high dropout rate in addiction research was discussed.
Conclusions: Currently, there is insufficient evidence to recommend the use of transcranial magnetic stimulation in the treatment of alcohol dependence. The results of the studies conducted to date are mixed. This is due, among other things, to the choice of different protocols, techniques and stimulation sites. For a reliable assessment of the effectiveness of this form of therapy, more andomized double-blind clinical trials and a sufficiently long follow-up period are needed.

Keywords: alcoholism, transcranial magnetic stimulation, therapeutics, biological psychiatry