bluuebunny/crossref_metadata_2025 huggingface dataset:
Empreendedorismo, inovação e sustentabilidade: Proposta de uma plataforma de gestão para implantação de uma usina solar fotovoltaica
Authors: Brito Merivaldo de Freitas , Oliveira Fabio Mendes de , Fonseca Mayara Oliveira , Duarte João Batista Furlan , Sacramento Elissandro Monteiro do , Lima Lutero Carmo de
Published: September 2023

Cada vez mais, a geração distribuída se torna uma prática comum, encontrando aplicação tanto em residências e estabelecimentos comerciais quanto em instalações de geração centralizada, como grandes usinas fotovoltaicas. O principal objetivo está na proposta da plataforma Solar Energy 4.0 para impulsionar a integração entre empreendedorismo, inovação e sustentabilidade no contexto da implantação de usinas de energia solar fotovoltaica. A formação de profissionais qualificados e a criação de empresas especializadas podem beneficiar a economia local, gerando oportunidades de trabalho e contribuindo para o desenvolvimento socioeconômico das comunidades. No contexto atual, a energia solar fotovoltaica representa uma parte significativa do Produto Interno Bruto (PIB) do Brasil, e essa proposta visa fortalecer ainda mais esse setor em rápido crescimento. A proposta busca atender a essa demanda crescente, capacitando empreendedores e profissionais do setor de energia renovável a adotar abordagens sustentáveis e inovadoras em seus projetos fotovoltaicos. Para alcançar esse objetivo, apresenta-se uma plataforma de gestão que permitirá o planejamento, execução e monitoramento eficiente de projetos solares. Como metodologia se baseou em uma revisão bibliográfica de caráter narrativo, e foi realizada uma busca de forma sistemática de livros, artigos científicos e periódicos online publicados entre o período 2013 a 2023, nas bases de dados periódicos CAPES e Google acadêmico, que abordam sobre a energia solar na atualidade e as perspectivas após a implementação das novas regulamentações para os consumidores e geradores de energia solar fotovoltaica. Dentre os resultados, buscam-se alinhar empreendedorismo, inovação e sustentabilidade na gestão de projetos de energia solar fotovoltaica. Com a plataforma de gestão proposta e a capacitação dos profissionais, espera-se impulsionar o crescimento do setor de energia solar, contribuindo para um futuro mais sustentável e econômico.
SOSIALISASI SISTEM E-BOOKING RUANG KELAS OLEH PENANGGUNG JAWAB MATA KULIAH MENGGUNAKAN QR CODE BERBASIS WEB DI STIKES DHARMA LANDBOUW PADANG TAHUN 2022
Authors: Yulfa Yulia  , Oktamianiza  , Ayunda Putri Kalasta , Ilahi Vitratul , Afridon  , Rahmadhani  , Mahelfi Irfan
Published: September 2023

Institusi pendidikan, tidak selamanya ruangan yang tersedia di sebuah institusi tersebut sesuai dengan jumlah mahasiswa yang ada, sehinggaperlu dilakukan penyusunan jadwal ruang kuliah dan jadwal perkuliahan. Untuk mempermudah hal tersebut peniliti membuat sebuah rancangan sistem booking ruang kelas menggunakan QR Code guna menghindari bentrok penggunaan ruang kelas. Mengidentifikasi alur proses pembokingan kelas oleh  penanggung jawab.Mengidentifikasi data yang dibutuhkan dalam penelitian dan terciptanya sebuah rancangan system yang tentunya sangat membantu mengetahui jumlah ketersediaan ruang kelas untuk proses belajar mengajar secara tatap muka. Metode yang dipakai  prototype untuk merancang sistem informasi. Prototy model perangkat lunak. Metode penelitian ini menggunakan pengembangan. R&D untuk menguji keefektifan produk tersebut. Berdasarkan kajian didapatkan bahwa pengujian menggunakan sistem ini, pemesanan ruang kelas tidak perlu dilakukan langsung ke ketua jurusan Adak, pemesanan lebih cepat, ruang  kelas yang tersedia juga detail, sehingga lebih mudah bagi siswa untuk memesan ruang kelas. Sistem reservasi  ruang kelas memberikan informasi  tentang  mata  kuliah yang  kosong  dan dapat memudahkan siswa atau guru untuk melakukan reservasi ruang kelas untuk mata kuliah tatap muka.Sistem reservasi kelas memberikan informasi tentang kamar yang tersedia yang dapat dipesan siswa tanpa harus bertemu langsung dengan staf adak. Perlunya mengedukasi pengguna menggunakan sistem agar dapat bekerja secara maksimal
UPAYA PENINGKATAN PEMBERDAYAAN MASYARAKAT DAN UPAYA PENANGGULANGAN BANJIR PROGRAM DESA MARITIM DI KELURAHAN TAMBAKREJO
Authors: Zumarnis Azziya Rahmatina , Wulan Widya Ratna , Dewi Fany Kusuma , Nadianto Bagas , Azizah Siti Nur , Hidayanti Elvan Fadilah , Hasanah Naila Fadla , Cahya Rachel Indira Dwi , Nani Tri Aisah , Kafita Luk Luil , Maulida Winda Rahma , Nisa Khofifatun , Dewi Septya Kumala , Nabila Najma , Priyanov Duta Candra Julian , Hariono Rini Wulansari
Published: September 2023

Kelurahan Tambakrejo merupakan kelurahan paling utara di wilayah Kecamatan Gayamsari, Kota Semarang. Tambakrejo berlokasi dekat dengan laut dan tambak, menjadikan kelurahan di Gayamsari ini terkenal akan perekonomian yang berbasis pada penangkapan dan pemrosesan ikan, khususnya ikan bandeng. Mayoritas 50% warga Tambakrejo berprofesi sebagai nelayan dan buruh industri pengolahan ikan. Belum ada program pengolahan sampah atau limbah yang sangat diperlukan ketika terdapat industri pengolahan ikan agar tidak menimbulkan dampak negatif terhadap lingkungan sekitar. Tambakrejo menjadi langganan banjir saat musim penghujan, genangan air setelah banjir membutuhkan waktu cukup lama untuk surut sehingga mengganggu mata pencaharian mereka. Lokasi daerah yang memiliki jarak cukup dekat dengan laut, tempat pembuangan sampah yang kurang layak, serta saluran pembuangan air yang sangat kotor dan berbau. Berangkat dari permasalahan tersebut Program kegiatan pengabdian kepada masyarakt di Kelurahan Tambakrejo telah dilaksanakan oleh Tim Program Penguatan Kapasitas Organisasi Kemahasiswaan (PPK Ormawa) Tobacco Free Community (TFC) Fakultas Kesehatan Universitas Dian Nuswantoro bekerjasama dengan beberapa mitra dan instansi. Program-program tersebut diantaranya adalah edukasi tentang stunting dan PMT serta pembagian PMT pada sektor kesehatan, Penanaman pohon dan pembentukan Tim Kelurahan Siaga Bencana (KSB) pada sektor lingkungan, demo memasak dan digital marketing pada sektor pendidikan, serta kelas wirausaha pada sektor ekonomi dan pendidikan.
SEAKEEPING EVALUATION OF SHIPS FOR OPERATIONAL PLANNING IN THE GULF OF GUINEA
Authors: . Ugor , Adie Orji Edward , u Charles ,   Rivers State University
Published: September 2023

This paper evaluates the sea-keeping characteristics of a Platform Supply Vessel (PSV) for operational planning in the Gulf of Guinea according to the respective international requirements or standard criteria. The ship’s design and operation characteristics were examined, the characteristics of the specified sea environment in which the ship should perform its mission were assessed, the impact of the specified sea environment on the design and operation of the ship was evaluated and ultimately, the operational criteria that should not be exceeded, so that the ship can perform its mission effectively was determined. Structural Analysis and Design Computer-Aided Design (SACS CAD) Software was employed to model the ship design and it was subjected to the environment in which it is to operate. The Joint North Sea Wave Project (JONSWAP) spectrum was used to model the local wind sea wave with Orca Finite Element Analysis of Flexible Systems (ORCAFLEX). This analysis showed the dynamic movement of the Platform Supply Vessel (PSV) in the various degrees of freedom (heave, surge, sway, yaw, roll, and pitch). Broad-based results showed that the PSV is fit to be operational. This was because of the various tests that were conducted for normal conditions. The various degrees of freedom offset exerted by the PSV were below the tolerance limit of platform supply vessels (10% of water depth of 100m=10m). The results obtained were for the south, the heave offset of 1.6032m and surge offset of 2.1507m. For the southwest, the heave offset of 1.5033m, the surge offset of 1.0712m, and the sway offset of 1.0753m. For the west, the heave offset of 1.068m, and the sway offset of 1.2114m. Local Sea wind wave in the south direction (180°) exerts the most environmental loading on the designed PSV. This was because of the result obtained for the extreme condition (heave offset of 1.9571m and surge offset of 1.4107m. The PSV stability parameters were also obtained as summarized in Appendix C and known to be within the limit of acceptability and validated by comparing the righting lever, GZ, of the designed PSV in Figure 16 with that obtained by marine.info (2021). Both righting levers, GZs were above the 30 degrees requirement of UKMCA (2008) criteria for PSVs. The GZ obtained was 62.8 degrees which should not be exceeded to prevent the PSV from capsizing. The study contributes to the body of knowledge surrounding seakeeping evaluations of PSVs and serves as a foundation for evaluating the design and performance of these vessels in the demanding offshore environment
MAPPING OF SOIL PROPERTIES FOR THE STATE OF GOA
Authors:   ME Foundation, Goudar Subash , Naik Prof. Dr. Nisha ,   Department of Civil Engineering GEC
Published: September 2023

Soil is the most important yet neglected factor in the construction projects. All structures, houses, highways, bridges, dams and even life itself is dependent on soil. Many consumers see soil analysis as a fund loss despite being the cheapest in the construction process, the cost of soil testing is hardly up to one percent of the construction cost. Some contractors also ignore the importance of proper soil research and analysis and base their design on assumed bearing capacity and settlement rate. The present paper is based on mapping all the soil index properties. In this work bore logs are collected from different agencies. The necessary data is extracted from bore logs and mapping of index properties is carried out. These maps will help the engineers and contractors to get a general idea of the soil strata and help them to design the foundations and carry out other construction works.
Formación del emprendimiento y madurez de incubadoras de empresas: Caso de la universidad pública peruana
Authors: Véliz Quispe Tomás , Véliz Gonzales Carol Fabiola , Véliz Zeballos Jorge Eduardo , Arroyo Beltrán Miguel Martín
Published: September 2023

El emprendimiento y las incubadoras de empresas traen consigo desafíos y oportunidades en las universidades públicas del Perú. Ante ello, el propósito del artículo es caracterizar la formación emprendedora a partir del rol que cumplen las universidades públicas, y evaluar la madurez de las incubadoras de empresas de las mismas. El enfoque del trabajo es cuantitativo, tipo transversal descriptivo-analítico, con una muestra de 07 universidades públicas, usando la técnica de encuesta a 180 estudiantes y 03 entrevistas a expertos. Los resultados denotan la deseabilidad para crear una empresa MYPE en un 46%, para laborar en una empresa o institución un 33%, y para crear un emprendimiento tecnológico un 20%; el fortalecimiento del fomento emprendedor en un 53% a nivel regular y la madurez de incubadoras de empresas en promedio 3.13 puntos sobre 4. Se concluyó que el fortalecimiento del fomento emprendedor es de carácter académico en base a competencias de acuerdo a currículo, y concebido de acuerdo a competencias, capacidad innovadora y elaboración de planes de negocios más no está orientada a la investigación formativa tecnológica y gestión de start-up/spin-off. La zona Hub centro, con experiencias de emprendimiento co-incubación startup y spinoff, de base tecnológica Spin-Off, mayor crecimiento de patentes registradas y con un nivel de madurez de las incubadoras avanzado/mediano; las zonas norte y sur HUB de emprendimiento con algunas experiencias de incubación start-up, bajo crecimiento número de patentes y con un nivel de madurez de incubadoras modesto/mediano
The politics of humanity: On anthropological science fiction in Peru
Authors: Branca Domenico
Published: September 2023

As a geocultural and temporally defined form of production, science fiction is fully within the scope of anthropological analysis. In this article, I aim to analyze the representation of the notion of humanity in Latin American science fiction. Specifically, I examine four narratives by Peruvian authors that offer a critical political lens on contemporary Peruvian society. As the notion of humanity is a complex and multifaceted concept explored by different disciplines, I seek to contribute to the discussion by providing a case study from social anthropology. Science fiction is a particularly relevant medium for social and political critique, as it allows for exploring real and contemporary situations by constructing possible worlds. Methodologically, I approach these four narratives ethnographically, that is, by contextualizing them within the Peruvian socio-political space. In terms of analysis, this article is framed within the anthropological exploration of colonial relations, the construction of social classifications, the boundaries and borders between the human and the non-human, and human impacts on the planet. I argue that science fiction can offer innovative perspectives that enrich a critical anthropological perspective.
Analyzing The Effect of Behavioral Intention on the Actual System Use in The Taspen Authentication System in The Jabodetabek Area
Authors: Rachmadi Fuji Widya , Yuningtyas Intisha Hafni , Candra, S.Kom., S.E., M.M. Dr. Ir. Sevenpri
Published: September 2023

A behavior to keep using technology can be seen from the attitude of attention to information technology. Behavior is a form of will, that is, willing to keep using, willing to add supporting features, as well as to be influenced to motivate others to use the technology. A successful implementation of information technology can be seen by paying attention to the behavior of the user. The PT. TASPEN (PERSERO), one of the state-owned enterprises engaging in non-banking finance, has digitized its services since 2017, one of which is by utilizing technology in terms of providing easiness for the participants, namely the participants of Taspen Pension who try to change the paradigm of withdrawing their monthly retirement salaries, which is from manual to digital. This study aims to determine the phenomenon of utilizing the technology established by Taspen to simplify retirees through behavioral intention influenced by several factors: performance expectancy, effort expectancy, social influence, trust, and facilitating conditions; to get an actual system use from the service digitalization established, i.e., the Taspen authentication system. The respondents to be addressed are the participants of Taspen Pension within the JABODETABEK area, whether they have used the Taspen authentication system or vice versa.
Rus Askeri Ajanı Emanuil Hristiyanoviç Kalnin’e Göre Boğazların İşgali Meselesi (1905)
Authors: BOZKURT Uğur
Published: September 2023

Çalışmanın amacı Çarlık Rusya’nın, Japonya’ya yenilgisinden sonra (1905) uluslararası arenada siyasî otoritesini yeniden tesis etmek bağlamında Osmanlı Devleti’nin elinde bulunan Boğazları işgal etme girişimini, bir askerî ajan olan ve Odessa Askerî Bölge Karargâhı yöneticilerinden Emanuil Hristiyanoviç Kalnin’in bakış açısıyla değerlendirmektir. Çalışma, Kalnin’in resmi yazışmalarından ve konuyla ilgili yayınladığı makalesinden istifade edilerek hazırladı. Ayrıca, yardımcı kaynaklarla desteklenerek Boğazların işgali meselesi farklı bir bakış açısıyla ele alındı. Çarlık Rusya’nın tarihi bir misyon olarak görülen İstanbul ve Boğazları işgal etme amacının olmadığını savunan Kalnin, böyle düşünülmesinin sebebini Avrupalı devletlerin yönlendirmelerinden ve dönemin ırkçı yaklaşımlarından kaynaklandığını vurgulamaktadır. Gazete siyasetçilerinin ve stratejistlerinin telkinlerine göre hareket edilmesinin sakıncaları üzerinde duran Kalnin, Çarlık Rusya’nın, İstanbul ve Boğazları işgal etmesi durumunda zarar göreceğini gerekçeli olarak açıklamaktadır. Bu bağlamda İstanbul, Balkan halklarının kültürel mirası olmakla birlikte burada yaşayan halk, Çarlık Rusya’nın, dindaşı ve ırkdaşıdır. Çarlık Rusya tarafından İstanbul’a olası bir işgal girişimi, kendisine yönelik düşmanlıkların oluşmasına neden olabilecektir. Dolayısıyla, yapılması gereken, Slavların bağımsız devlet kurmalarını desteklemek ve Çarlık Rusya’ya herhangi bir fayda sağlamayacak olan İstanbul ve Boğazların işgali projesini durdurmaktır.
Kentin Kurgusal Mekânları Olarak Rekreatif Yeşil Alanlar ve Parklar Üzerine Sosyolojik Bir Araştırma: Konya Örneği1
Authors: UYANIK Hale Nur
Published: September 2023

Bu çalışma, kent içerisinde yaşamını sürdüren bireylerin, gündelik hayatlarında zamanlarını değerlendirmek üzere kent mekanları olarak yeşil alanların (park, bahçe, rekreasyon gibi) kullanımına yönelik sosyolojik nedenleri ortaya koymayı amaçlayan bir araştırmadır. Herhangi bir toplumun kent kimliğini, kentin insan üzerinde yaratmış olduğu etkiyi anlama açısından kentin mekânları ve bu mekânlar içerisinde yapılan pratikleri ve eylemleri sosyolojik muhayyile çerçevesinde değerlendirmek önemlidir. Bireylerin yaşamış oldukları kent içerisinde bulunan mekânlar ile kurdukları ilişkiyi ortaya koymak bizlere o kentin içerisinde yaşayan insanların gündelik yaşam pratiklerini anlamak o kentin tarihsel serüveni hakkında malumat verir. Bu çalışmada kent parklarının, yeşil alanların bir diğer görevi olan “toplumsal etkileşim” sürecine nasıl bir etki sağladığı üzerinde durulmuştur. Çalışmada örnek olarak incelenen şehir olan Konya kentinde yer alan belediyelere ait parkların işlevi ve parkların kentsel mekânların bir parçası olarak süreç içerisinde kazandırdığı sosyalleşme etkisi üzerinde değerlendirmelerde bulunulmuştur. Çalışmada Konya halkı özelinde parkları ve yeşil alanları neden tercih ettikleri, belediyenin yaptığı tematik unsurular taşıyan mekânlara yönelime dair görüşmeler yapılarak ideal kent bağlamında doğa içerisinde inşa edilen bu tarz mekânların tercihlerinin nedenleri ortaya koyulmuştur.
Development of a Reflective Practice Guideline (C-E-R-M-I-N) for Nursing Students in the Malay Language
Authors: Ellin Mohammed Rasheedan , Dayang Zuraina binti Abang Haji Kashim  , Abu Bakar Mohamad Azhari
Published: September 2023

Reflective practice is an integral aspect of nursing education and professional development. However, there is a lack of reflective practice guidelines available in Malay that Malaysian nursing students can effectively utilise. This study aimed to address the gap by developing a reflective practice guideline specifically tailored for nursing students in the Malay language to enhance their learning experience. This study's method involved reviewing existing reflective learning models, adapting the terminologies into the Malay language, and selecting appropriate words for each stage of reflection. To ensure face validity, a discussion was held with subject matter experts, who provided valuable insights and recommendations for further refinement of the guideline. The developed reflective practice guideline was named C-E-R-M-I-N, which stands for C-cerita (describe), E-emosi (emotion), R-rasional (rationale), M-mengambil iktibar/inisiatif (drawing lessons/initiative), and N-nomborkan mengikut prioriti (number according to priority). The C-E-R-M-I-N reflective practice guideline is designed to benefit nursing students, particularly those who use Malay as their main communication language. C-E-R-M-I-N provides a framework in their native language that eases comprehension and memory. Future work on the guideline could focus on its impact on nursing students' reflective skills, critical thinking skills, and overall professional growth.
Exploring Background Noise During Learning: A Neurofeedback Study
Authors: Nasaruddin Nurul Hanim , Farah Dania Hipni  , Noraisah Arbadul
Published: September 2023

Distinguishing effective background noise during learning is crucial for students. This study was conducted to determine the effective noise background during learning. Two healthy female subjects were recruited for this experiment. They were put in separate brainwave recording sessions for learning tasks without noise and with background noise. Their theta and alpha brainwave readings showed higher activity while learning with background noise. The finding indicated that both brainwaves represented insight and alertness were more dominant during active learning tasks than without noise. However, there was no statistically significant difference in both learning conditions for theta (p = 0.09) and alpha (p = 0.07) brainwaves. The higher activity level during the learning process with background noise could be interpreted as a sign of enhanced cognitive insight and alertness. Nonetheless, the magnitude of the difference observed did not reach a statistically significant level, thus necessitating further investigation and analysis.
ANALISIS KINERJA PENDINGIN SETELAH PROSES PEMBERSIHAN SECARA KIMIA DI PT AJINOMOTO MOJOKERTO
Authors: Anggraeni Devi Risma , Suharti Profiyanti Hermien , Nazar Ibadul Wasi’an
Published: September 2023

Pendingin air merupakan salah satu utilitas penting dalam industri proses, karena memiliki peran yang sangat penting dalam setiap aplikasi. Penggunaan pendingin semakin lama tentunya akan membuat kinerja pendingin akan menurun. Ketika kinerja pendingin menurun maka akan membutuhkan energi lebih banyak untuk menghasilkan beban pendingin yang sama. Hal ini terjadi di PT Ajinomoto yang ditandai tekanan dan temperatur pada kondensor naik mendekati batas maksimal yang diharuskan yaitu  0.9 Mpa dan  40˚C. Penurunan kinerja pendingin ini terjadi akibat adanya kotoran atau kerak yang menempel dalam kondensor. Untuk mengatasi adanya kerak perlu mengambil tindakan perawatan. Penelitian ini bertujuan untuk mengetahui kinerja pendingin sebelum dan setelah perawatan, khususnya dilihat dari nilai COP. Dari permasalahan tersebut telah dilakukan tindakan perawatan dengan pembersihan secara kimia pada alat pendingin di PT Ajinomoto. Hasil didapatkan setelah pembersihan secara kimia adalah tekanan kondensor mengalami penurunan dari rata-rata 0.9 Mpa menjadi 0.7 Mpa, untuk temperatur kondensor dari rata-rata 38.3˚C menjadi 35.7˚C. Selain itu, untuk Coefficient of Performance (COP) naik dari awalnya 4,1 menjadi 7,39. Agar permasalahan ini tidak terjadi kembali perlu dilakukan pengecekan dan pembersihan berkala pada pendingin agar kerak yang menempel pada dinding pipa lebih mudah dibersihkan.
PELATIHAN DARING PENGGUNAAN KALKULATOR SAINTIFIK UNTUK MENINGKATKAN HARAPAN MAHASISWA YANG MENGAMBIL MATA KULIAH PSIKOMETRIKA
Authors: Natanael Yonathan , Ramdani Zulmi , Zahara Fidia Hanan
Published: September 2023

Kalkulator saintifik biasanya banyak digunakan oleh mahasiswa terlebih di jurusan matematika dan pendidikan matematika dan ilmu-ilmu alam lainnya. Dengan begitu, tujuan dari pengabdian ini yaitu untuk melihat perubahan harapan mahasiswa psikologi dengan menyediakan pelatihan yang penting dengan menggunakan kalkulator saintifik melalui tutorial video yang digunakan untuk menyelesaikan hitungan reliabilitas dalam mata kuliah psikometri. Metode pengabdian yang digunakan menggunakan pendekatan kuasi eksperimental (kelompok tunggal dengan pretes dan postes). Partisipan yang terlibat sejumlah 51 orang pada program psikologi yang bersedia untuk berpartisipasi dalam kegiatan pengabdian ini. Analisis menggunakan paired sample t-test dengan hasil t = -3.954 dan signifikansi di bawah 5%. Hal ini mengindikasikan bahwa terdapat perubahan harapan pada mahasiswa yang meningkat. Aktivitas pengabdian ini bisa meningkatkan belajar siswa terutama dalam hal harapan dan ketertarikannya dalam mempelajari pengetahuan yang baru.

 
Scientific calculators are generally used more by science students, especially those majoring in Mathematics and Other Sciences. Therefore, this community service activity aims to see changes in hope for students majoring in Psychology by providing essential training on using scientific calculators through video tutorials to complete reliability calculations in Psychometrics courses. A community service method is an educative approach accompanied by a quasi-experimental approach (single group pre-test and post-test). The participants of this activity were 51 students majoring in Psychology who were willing to participate in this initial pioneering activity voluntarily. The analysis using the paired sample t-test yielded a value of t = -3.954 and a significance of 0.00 <0.05, which indicated a change in students' hope to increase. The activities can impact student learning of hope and interest in the newly learned knowledge.
Development of Interactive E-Module on Learning IPAS
Authors: Yunita Susanti  , Suci Islami  , Windy Widya Kusuma Ningrum  , Asep Nuryadin  , Muhammad Aizuddin bin Ab Alim
Published: September 2023

This research aims to develop an interactive e-module as an additional learning media for fourth-grade elementary schools in the Natural and Social Sciences subject (IPAS). The study was conducted utilizing the ADDIE approach of research and development. Fourth-grade students and instructors at SDN Cikadongdong verified the product before it was released. Observation, interviews, and questionnaires were used as the primary methods of data collection. The results of product trials based on the teacher’s response showed a score of 95.8%, which was in the very good category. In addition, students’ responses based on interview results showed that the students liked the interactive e-module because the appearance of the interactive e-module was attractive, not boring, and easy to use. Thus, it can be concluded that the interactive e-module is considered a very good category and is suitable to use as an additional learning medium in fourth-grade Natural and Social Sciences learning.
Diagnostic therapeutic assistance pathway (PDTA) of type 2 chronic rhinosinusitis
Authors: Canevari Frank Rikki , Giorli Alessia , Monti Giulia , Biagini Cesare , Bagnasco Diego , Cavaliere Carlo , Pipolo Carlotta , De Corso Eugenio , Gelardi Matteo , Gramellini Giulia , Ioppi Alessandro , La Mantia Ignazio , Malvezzi Luca , Bignami Maurizio , Dehgani-Mobaraki Puya , Seccia Veronica , Maggiore Giandomenico , Macchi Alberto
Published: September 2023

Chronic rhinosinusitis (CRS) is a complex and heterogeneous disorder whose etiopathogenetic picture is not yet completely known and is classically divided into CRS with (CRSwNP) and without nasal polyps (CRSsNP). But today the distinction is made with type 2 and nontype 2 variants. A rational and defined pathway for the diagnosis of chronic rhinosinusitis is an indispensable means to be able to arrive at a correct identification of the patient. This typing is essential to be able to arrive at the correct course of treatment, which turns out to be different for different types of patients. For this reason, the realization of a diagnostic therapeutic pathway represents a fundamental way for the otolaryngologist specialist but not only, since today diagnostics has a multidisciplinary framework. In the present work, precise indications have been developed to arrive at a correct diagnosis. The various diagnostic pathways and processes to arrive at a correct therapeutic framing have been highlighted. Therapy ranging from medical therapy to surgical therapy without neglecting the new biological therapies. It does not represent a guideline but a diagnostic method that can be adapted to all the various territorial realities.
Evolving technology: the TRIFLO tri-leaflet mechanical valve without oral anticoagulation: a potential major innovation in valve surgery
Authors: Carrel Thierry , Vogt Paul R. , Obrist Dominique , Schaff Hartzell
Published: September 2023

The aortic valve is the most frequently diseased valve and aortic stenosis (AS) is the most prevalent valvular heart disease in developed countries. The diseased native aortic valve can be replaced by either a biological or mechanical valve prosthesis. The main concerns relate to durability, the need for oral anticoagulants and the incidence of complications related to this medication. Experimental, computational and biomolecular blood flow studies have demonstrated that the systolic forward flow but also the reverse flow phase at the end of the systole and leakage during the diastolic phase is mainly responsible for platelet activation and thrombosis. Better design of mechanical prosthetic heart valves must ensure smooth closing during flow deceleration and must eliminate high-shear hinge flow during diastole to prevent life-threatening thrombosis. A novel tri-leaflet valve should combine the favorable hemodynamics and the durability of existing mechanical heart valves and eliminate the less favorable characteristics, including the extremely rapid closing. In this paper, we discuss some issues of current mechanical heart valve prostheses and present a new valve design with the potential for significant innovation in the field. The TRIFLO Heart Valve, is a rigid, three-leaflet central flow heart valve prosthesis consisting of an alloyed titanium housing, and three rigid polymer (PEEK) cusps. This valve has a physiological operating mode. During the forward flow phase, the intraventricular pressure opens the leaflets so that blood can freely flow through with little obstruction, and with the deceleration of the blood flow, the leaflets close early and smoothly, minimizing blood flow regurgitation, blood cell damage, and activation of the coagulation cascade. Pre-clinical studies have shown pretty favorable results and a first-in-man study should start very soon.
Predictive value of first-trimester GPR120 levels in gestational diabetes mellitus
Authors: He Qingwen , Lin Mengyuan , Wu Zhenhong , Yu Renqiang
Published: September 2023

Background

Early diagnosis of gestational diabetes mellitus (GDM) reduces the risk of unfavorable perinatal and maternal consequences. Currently, there are no recognized biomarkers or clinical prediction models for use in clinical practice to diagnosing GDM during early pregnancy. The purpose of this research is to detect the serum G-protein coupled receptor 120 (GPR120) levels during early pregnancy and construct a model for predicting GDM.

Methods

This prospective cohort study was implemented at the Women’s Hospital of Jiangnan University between November 2019 and November 2022. All clinical indicators were assessed at the Hospital Laboratory. GPR120 expression was measured in white blood cells through quantitative PCR. Thereafter, the least absolute shrinkage and selection operator (LASSO) regression analysis technique was employed for optimizing the selection of the variables, while the multivariate logistic regression technique was implemented for constructing the nomogram model to anticipate the risk of GDM. The calibration curve analysis, area under the receiver operating characteristic curve (AUC) analysis, and the decision curve analysis (DCA) were conducted for assessing the performance of the constructed nomogram.

Results

Herein, we included a total of 250 pregnant women (125 with GDM). The results showed that the GDM group showed significantly higher GPR120 expression levels in their first trimester compared to the normal pregnancy group (p < 0.05). LASSO and multivariate regression analyses were carried out to construct a GDM nomogram during the first trimester. The indicators used in the nomogram included fasting plasma glucose, total cholesterol, lipoproteins, and GPR120 levels. The nomogram exhibited good performance in the training (AUC 0.996, 95% confidence interval [CI] = 0.989-0.999) and validation sets (AUC=0.992) for predicting GDM. The Akaike Information Criterion of the nomogram was 37.961. The nomogram showed a cutoff value of 0.714 (sensitivity = 0.989; specificity = 0.977). The nomogram displayed good calibration and discrimination, while the DCA was conducted for validating the clinical applicability of the nomogram.

Conclusions

The patients in the GDM group showed a high GPR120 expression level during the first trimester. Therefore, GPR120 expression could be used as an effective biomarker for predicting the onset of GDM. The nomogram incorporating GPR120 levels in early pregnancy showed good predictive ability for the onset of GDM.
Novel insights into the role of acetyl-CoA producing enzymes in epigenetic regulation
Authors: Russo Marta , Pileri Francesco , Ghisletti Serena
Published: September 2023

Inflammation-dependent changes in gene expression programs in innate immune cells, such as macrophages, involve extensive reprogramming of metabolism. This reprogramming is essential for the production of metabolites required for chromatin modifications, such as acetyl-CoA, and regulate their usage and availability impacting the macrophage epigenome. One of the most transcriptionally induced proinflammatory mediator is nitric oxide (NO), which has been shown to inhibit key metabolic enzymes involved in the production of these metabolites. Recent evidence indicates that NO inhibits mitochondrial enzymes such as pyruvate dehydrogenase (PDH) in macrophages induced by inflammatory stimulus. PDH is involved in the production of acetyl-CoA, which is essential for chromatin modifications in the nucleus, such as histone acetylation. In addition, acetyl-CoA levels in inflamed macrophages are regulated by ATP citrate lyase (ACLY) and citrate transporter SLC25A1. Interestingly, acetyl-CoA producing enzymes, such as PDH and ACLY, have also been reported to be present in the nucleus and to support the local generation of cofactors such as acetyl-CoA. Here, we will discuss the mechanisms involved in the regulation of acetyl-CoA production by metabolic enzymes, their inhibition by prolonged exposure to inflammation stimuli, their involvement in dynamic inflammatory expression changes and how these emerging findings could have significant implications for the design of novel therapeutic approaches.
Host-directed therapy for bacterial infections -Modulation of the phagolysosome pathway-
Authors: Taya Toshihiko , Teruyama Fumiya , Gojo Satoshi
Published: September 2023

Bacterial infections still impose a significant burden on humanity, even though antimicrobial agents have long since been developed. In addition to individual severe infections, the f fatality rate of sepsis remains high, and the threat of antimicrobial-resistant bacteria grows with time, putting us at inferiority. Although tremendous resources have been devoted to the development of antimicrobial agents, we have yet to recover from the lost ground we have been driven into. Looking back at the evolution of treatment for cancer, which, like infectious diseases, has the similarity that host immunity eliminates the lesion, the development of drugs to eliminate the tumor itself has shifted from a single-minded focus on drug development to the establishment of a treatment strategy in which the de-suppression of host immunity is another pillar of treatment. In infectious diseases, on the other hand, the development of therapies that strengthen and support the immune system has only just begun. Among innate immunity, the first line of defense that bacteria encounter after invading the host, the molecular mechanisms of the phagolysosome pathway, which begins with phagocytosis to fusion with lysosome, have been elucidated in detail. Bacteria have a large number of strategies to escape and survive the pathway. Although the full picture is still unfathomable, the molecular mechanisms have been elucidated for some of them, providing sufficient clues for intervention. In this article, we review the host defense mechanisms and bacterial evasion mechanisms and discuss the possibility of host-directed therapy for bacterial infection by intervening in the phagolysosome pathway.
Bioinformatics-based analysis of the roles of basement membrane-related gene AGRN in systemic lupus erythematosus and pan-cancer development
Authors: Lv Rundong , Duan Lei , Gao Jie , Si Jigang , Feng Chen , Hu Jun , Zheng Xiulan
Published: September 2023

Introduction

Systemic lupus erythematosus (SLE) is an autoimmune disease involving many systems and organs, and individuals with SLE exhibit unique cancer risk characteristics. The significance of the basement membrane (BM) in the occurrence and progression of human autoimmune diseases and tumors has been established through research. However, the roles of BM-related genes and their protein expression mechanisms in the pathogenesis of SLE and pan-cancer development has not been elucidated.

Methods

In this study, we applied bioinformatics methods to perform differential expression analysis of BM-related genes in datasets from SLE patients. We utilized LASSO logistic regression, SVM-RFE, and RandomForest to screen for feature genes and construct a diagnosis model for SLE. In order to attain a comprehensive comprehension of the biological functionalities of the feature genes, we conducted GSEA analysis, ROC analysis, and computed levels of immune cell infiltration. Finally, we sourced pan-cancer expression profiles from the TCGA and GTEx databases and performed pan-cancer analysis.

Results

We screened six feature genes (AGRN, PHF13, SPOCK2, TGFBI, COL4A3, and COLQ) to construct an SLE diagnostic model. Immune infiltration analysis showed a significant correlation between AGRN and immune cell functions such as parainflammation and type I IFN response. After further gene expression validation, we finally selected AGRN for pan-cancer analysis. The results showed that AGRN’s expression level varied according to distinct tumor types and was closely correlated with some tumor patients’ prognosis, immune cell infiltration, and other indicators.

Discussion

In conclusion, BM-related genes play a pivotal role in the pathogenesis of SLE, and AGRN shows immense promise as a target in SLE and the progression of multiple tumors.
Teriflunomide and Epstein–Barr virus in a Spanish multiple sclerosis cohort: in vivo antiviral activity and clinical response
Authors: Domínguez-Mozo María Inmaculada , González-Suárez Inés , Villar Luisa María , Costa-Frossard Lucienne , Villarrubia Noelia , Aladro Yolanda , Pilo Belén , Montalbán Xavier , Comabella Manuel , Casanova-Peño Ignacio , Martínez-Ginés María Luisa , García-Domínguez Jose Manuel , García-Martínez María Ángel , Arroyo Rafael , Álvarez-Lafuente Roberto
Published: September 2023

Background

Epstein–Barr virus (EBV) and human herpesvirus 6 (HHV-6) have been associated with multiple sclerosis (MS). Teriflunomide is an oral disease-modifying therapy approved for treatment of relapsing forms of MS. In the preclinical Theiler’s murine encephalitis virus model of MS, the drug demonstrated an increased rate of viral clearance versus the vehicle placebo. Furthermore, teriflunomide inhibits lytic EBV infection in vitro.

Objective

1. To evaluate the humoral response against EBV and HHV-6 prior to teriflunomide treatment and 6 months later. 2. To correlate the variation in the humoral response against EBV and HHV-6 with the clinical and radiological response after 24 months of treatment with teriflunomide. 3. To analyze the utility of different demographic, clinical, radiological, and environmental data to identify early biomarkers of response to teriflunomide.

Methods

A total of 101 MS patients (62 women; mean age: 43.4 years) with one serum prior to teriflunomide onset and another serum sample 6 months later were recruited. A total of 80 had been treated for at least 24 months, 13 had stopped teriflunomide before 24 months, and 8 were currently under teriflunomide therapy but with less than 24 months of follow-up. We analyzed the levels of the viral antibodies titers abovementioned in serum samples with ELISA commercial kits, and the levels of serum neurofilament light chain (Nf-L).

Results

Antiviral antibody titers decreased for EBNA-1 IgG (74.3%), VCA IgG (69%), HHV-6 IgG (60.4%), and HHV-6 IgM (73.3%) after 6 months of teriflunomide. VCA IgG titers at baseline correlated with Nf-L levels measured at the same time (r = 0.221; p = 0.028) and 6 months later (r = 0.240; p = 0.017). We found that higher EBNA-1 titers (p = 0.001) and a higher age (p = 0.04) at baseline were associated with NEDA-3 conditions. Thus, 77.8% of patients with EBNA-1 >23.0 AU and >42.8 years (P50 values) were NEDA-3.

Conclusion

Treatment with teriflunomide was associated with a reduction of the levels of IgG antibody titers against EBV and HHV-6. Furthermore, higher EBNA-1 IgG titers prior to teriflunomide initiation were associated with a better clinical response.
Modified activities of macrophages’ deubiquitinating enzymes after Francisella infection
Authors: Vozandychova Vera , Rehulka Pavel , Hercik Kamil , Spidlova Petra , Pavlik Pavla , Hanus Jaroslav , Hadravova Romana , Stulik Jiri
Published: September 2023

Francisella tularensis influences several host molecular/signaling pathways during infection. Ubiquitination and deubiquitination are among the most important regulatory mechanisms and respectively occur through attachment or removal of the ubiquitin molecule. The process is necessary not only to mark molecules for degradation, but also, for example, to the activation of signaling pathways leading to pro-inflammatory host response. Many intracellular pathogens, including Francisella tularensis, have evolved mechanisms of modifying such host immune responses to escape degradation. Here, we describe that F. tularensis interferes with the host’s ubiquitination system. We show increased total activity of deubiquitinating enzymes (DUBs) in human macrophages after infection, while confirm reduced enzymatic activities of two specific DUBs (USP10 and UCH-L5), and demonstrate increased activity of USP25. We further reveal the enrichment of these three enzymes in exosomes derived from F. tularensis-infected cells. The obtained results show the regulatory effect on ubiquitination mechanism in macrophages during F. tularensis infection.
Mechanisms underlying the beneficial effects of physical exercise on multiple sclerosis: focus on immune cells
Authors: Zong Boyi , Yu Fengzhi , Zhang Xiaoyou , Zhao Wenrui , Li Shichang , Li Lin
Published: September 2023

Multiple sclerosis (MS) is a prevalent neuroimmunological illness that leads to neurological disability in young adults. Although the etiology of MS is heterogeneous, it is well established that aberrant activity of adaptive and innate immune cells plays a crucial role in its pathogenesis. Several immune cell abnormalities have been described in MS and its animal models, including T lymphocytes, B lymphocytes, dendritic cells, neutrophils, microglia/macrophages, and astrocytes, among others. Physical exercise offers a valuable alternative or adjunctive disease-modifying therapy for MS. A growing body of evidence indicates that exercise may reduce the autoimmune responses triggered by immune cells in MS. This is partially accomplished by restricting the infiltration of peripheral immune cells into the central nervous system (CNS) parenchyma, curbing hyperactivation of immune cells, and facilitating a transition in the balance of immune cells from a pro-inflammatory to an anti-inflammatory state. This review provides a succinct overview of the correlation between physical exercise, immune cells, and MS pathology, and highlights the potential benefits of exercise as a strategy for the prevention and treatment of MS.
CDR2 and CDR2L line blot performance in PCA-1/anti-Yo paraneoplastic autoimmunity
Authors: Vorasoot Nisa , Scharf Madeleine , Miske Ramona , Thakolwiboon Smathorn , Dubey Divyanshu , Mills John R. , Pittock Sean J. , Zekeridou Anastasia , Ott Anthonina , McKeon Andrew
Published: September 2023

Background

Purkinje cytoplasmic autoantibody type 1 (PCA-1)/anti-Yo autoimmunity is a common high-risk paraneoplastic neurological disorder, traditionally attributed antigenically to cerebellar degeneration–related protein 2 (CDR2), predominantly affecting women with gynecologic or breast adenocarcinoma. Single-modality CDR2 testing may produce false-positive results. We assessed the performance characteristics of the more recently purported major PCA-1/Yo antigen, CDR2-like (CDR2L), side by side with CDR2, in a line blot format.

Methods

CDR2 and CDR2L were tested in six specimen groups (serum and cerebrospinal fluid (CSF)). Group 1, PCA-1/Yo mouse brain indirect immunofluorescence assay (IFA) positives; Group 2, PCA-1/Yo IFA mimics; Group 3, suspected CDR2 line blot false positives; Group 4, consecutive patient samples tested for neural antibodies over 1 year; Group 5, healthy subject serums; and Group 6, polyclonal (non-specific) immunoglobulin G (IgG)-positive serums.

Results

Group 1: Of 64 samples tested, all but two were CDR2 positive (both CSF samples) and all were CDR2L positive. In individual patients, CDR2L values were always higher than CDR2. The two “CDR2L-only” positives were CSF samples with low titer PCA-1/Yo by IFA with serum negativity but with typical clinical phenotype. Group 2: All 51 PCA-1/Yo mimics were CDR2/CDR2L negative. Group 3: Nine samples [six of 1289 (0.47%) serums and three of 700 CSF samples (0.43%) were PCA-1/Yo IFA negative/CDR2 positive; two of the six available (serums from the same patient) were also CDR2L positive; the other four CDR2L negative had low CDR2 values (17–22). Group 4: Twenty-two patients had unexpected CDR2 or CDR2L positivity; none had tissue IFA positivity. Eleven of the 2,132 serum (0.5%) and three of the 677 CSF (0.4%) samples were CDR2 positive; median value was 19 (range, 11–48). Seven of the 2,132 serum (0.3%) and three of the 677 CSF (0.4%) samples were CDR2L positive; median value was 18 (range, 11–96). Group 5: All 151 healthy serum samples were negative. Group 6: One of the 46 polyclonal serum samples was CDR2L positive. Optimum overall performance was accomplished by requiring both CDR2 and CDR2L positivity in serum (sensitivity, 100%; and specificity, 99.9%) and positivity for CDR2L in CSF (sensitivity, 100%; and specificity, 99.6%).

Conclusion

CDR2L provides additional PCA-1/anti-Yo sensitivity in CSF, and dual positivity with CDR2 provides additional specificity assurance in serum. Combining antigen-specific and tissue-based assays optimizes PCA-1/anti-Yo testing.