bluuebunny/crossref_metadata_2025 huggingface dataset:
Sweat Electrolyte Detection Patch for Non-invasive Hydration Monitoring
Authors: Rodriguez Jorge A. , Diaz-Alonso Daniela
Published: June 2024

The focus of this work lies in the construction of monitoring system designed in the form of a patch using a long-lasting potentiometric electrolyte concentration sensor from metal electrodes, in a galvanic cell configuration Mg(s)|NaCl(aq)|Cu(s). Initially, a mathematical analysis was conducted on the expected sensor output through the Nernst equation. The experimental phase involved conducting controlled tests in the laboratory using various molar concentrations of sodium chloride (NaCl) in aqueous solution. Results showed that the electrolyte sensor allows for monitoring electrolyte levels in NaCl in the range of 0.02 to 1 M/L, with electrode lifespan exceeding 10 days. On the other hand, when patch is using human sweat during controlled exercise routines, it showed the sensor's capability for monitoring changes in the subjects' hydration levels in real time. The sensor output potential is greater than 1.7 volts when the sensor electrodes are in contact with human sweat, which is equivalent to measuring molar concentrations at normal hydration and moderately high hydration levels. Sensor results indicate that the system can function in a self-powered manner without external batteries. Additionally, the extended lifespan of its electrodes allows for continuous monitoring of imbalances in the human body, showcasing the system capability for long-term health assessment.
Acute Care Rehabilitation Services Utilization and Post-acute Discharge Destination among Adults with Traumatic Brain Injury: The Moderating Effect of Functional and Physical Performance at Discharge
Authors: Bukhari Rayyan A. , Weaver Jennifer A. , Sharp Julia , Hoffman Amanda , Davalos Deana , Graham James
Published: June 2024

Objective: To investigate whether the relationships between acute care occupational therapy (OT) and physical therapy (PT) utilization and community discharge are moderated by functional or physical performance at discharge among individuals hospitalized with traumatic brain injury (TBI).
Setting: 14 acute care hospitals in the state of Colorado.
Participants: We studied 5,599 adults hospitalized with TBI between June 2018 and April 2021.
Design: In a secondary analysis of de-identified electronic health record (EHR) data, multivariable moderation logistic regression models were performed to calculate odds ratios (ORs) for the likelihood of community discharge among patients who utilized OT/PT services.
Main Measures: Functional (activities of daily living [ADL]) and physical (mobility) performance at discharge, OT and PT utilization, and community discharge status.
Results: Overall, 67% of patients discharged to the community. The mean age of the sample was 55 years (SD = 20 years). Most participants were male (64%) and non-Hispanic white (72%). Mean hospital length of stay was 6 days (SD = 6 days). Both OT and PT utilization (OT: OR= 1.21, 95% CI [1.11, 1.33]; PT: OR= 1.22, 95% CI [1.14, 1.30]) and discharge ADL and mobility scores (ADL: OR= 1.34, 95% CI [1.30, 1.39]; mobility: OR= 1.38, 95% CI [1.33, 1.42]) were significantly and positively associated with community discharge. The OT and PT utilization-by-discharge ADL and mobility interaction terms yielded slightly negative, but statistically significant moderation effects in both models (ORs= 0.99, 95% CIs [0.98, 1.00]); indicating the magnitude of the OT and PT utilization effect diminished as ADL and mobility scores increased. Several sociodemographic characteristics and clinical factors were also independently associated with community discharge in both models (p-values
Managing Teacher Education for Socio-Economic and Political Emancipation
Authors: Hazzan Moses Kayode
Published: June 2024

A nation's social, economic, and political emancipation is ineluctably connected with functional education systems in which people learn to create new institutions, utilise new technologies, cope with vagaries and difficulties in their environment, and positively alter their behavioural patterns. Education in a broad sense improves the capabilities of individuals and the capacity of institutions and becomes a catalyst for the closely interrelated economic, social, cultural, and political changes that are parts of the hallmarks of national development. Nevertheless, a teacher stands out as a crucial figure within any educational institution, wielding significant influence in effecting these changes and transformations. Teacher education is broad. It is based on the praxis that teachers are made in contrary to the assumption that teachers are born. Since teaching is considered an art and a science, the teacher has to acquire not only knowledge but also requisite skills needed in carrying out his or her inestimable duties or services. The efficiency and effectiveness of every educational system hinge significantly on the educational achievements of teachers. After all, no education can surpass the quality of its educators. Thus, every nation places demands and expectations on the teacher, which need to be addressed by both initial and continuing teacher education. On this note, this paper examines teacher education with respect to its praxis and professionalism, examines the nexus between teacher education and socioeconomic as well as political emancipation, analyses the challenges of teacher education in Nigeria, and in the final analysis, gives recommendations based on the identified challenges.
Diagnosis of Wilkie’s Syndrome Associated with Nutcracker Syndrome: A Case Report and Literature Review
Authors: Abenavoli Ludovico , Imoletti Felice , Quero Giuseppe , Bottino Valentina , Facciolo Viviana , Scarlata Giuseppe Guido Maria , Luzza Francesco , Laganà Domenico
Published: June 2024

Superior mesenteric artery (SMA) syndrome or Wilkie’s syndrome is a vascular compression disorder that causes abnormal compression of the third portion of the duodenum by the SMA. It has a low incidence rate, higher in young women, and is rarely associated with the Nutcracker phenomenon: a condition of compression of the left renal vein between the SMA and the aorta, which manifests as pain in the left flank and pelvis. Here we report the case of a 54-year-old woman with a history of repeated episodes of abdominal pain caused by the Nutcracker syndrome and Wilkie's syndrome.
Robot for Inclusive Education, Made by Students and Teachers of the EET No. 2 “Independence” of Concordia (ER), Argentina. Computer Technique Specialty
Authors: Anderson Ibar Federico
Published: June 2024

This study focuses on the design, development, and evaluation of an educational mobile robot, named Robot-T2, to be used in educational activities within a technical school. The primary objective was to create a versatile platform that allows students to explore programming, engineering, and science concepts in a practical and collaborative manner. The methodology included an iterative design and testing approach, incorporating feedback from students and teachers to continuously improve the robot's functionality. The tests covered autonomous navigation, line following, and object manipulation, using the OnBotJava programming software and the Control Hub as the main interface. The results demonstrated that Robot-T2 is highly efficient and adaptable in various educational contexts, showing remarkable precision in navigation and object manipulation. The design iterations significantly improved the robot's performance, enriching the educational experience and promoting active learning. In conclusion, educational robotics, represented by Robot-T2, has great potential to enhance the teaching and learning process in technical schools, fostering teamwork, problem-solving, and the integration of technology in the classroom. This project is expected to inspire future developments in educational robotics.
Clinicopathological Appearance of Epidermal Growth Factor-Containing Fibulin-Like Extracellular Matrix Protein 1 Deposition in the Lower Gastrointestinal Tract: An Autopsy-Based Study
Authors: Ichimata Shojiro , Hata Yukiko , Yoshida Koji , Nishida Naoki
Published: June 2024

This study examined the patterns of epidermal growth factor-containing fibulin-like extracellular matrix protein 1 (EFEMP1) deposition in the small intestine and colon to evaluate the association between histopathological severity of EFEMP1 deposition and constipation and determine if amyloid transthyretin (ATTR) and EFEMP1 deposits can colocalize. In 40 older cases (≥80 years of age), EFEMP1 deposition in the small intestine initiated in the submucosal and subserous vessels, subserous interstitium, and serosa (early stage); progressing to the muscularis propria and peri-Auerbach plexus area (intermediate stage); and finally, spreading diffusely to areas, excluding the mucosa and muscularis mucosa (advanced stage). The colon had a similar pattern of progression. During the middle-to-advanced stages, amyloid formation was observed in some vascular and serous deposits. We identified a subgroup of cases in which EFEMP1 deposition was the only presumed cause of constipation. Additionally, we demonstrated the colocalization of ATTR and EFEMP1 deposition. Apple-green birefringence was detected under polarized light only in approximately one-half of the cases in the small intestine and one-third of the cases in the colon. These findings emphasize that EFEMP1 deposits may be associated with lower gastrointestinal pathological conditions. Given the challenges of histopathological diagnosis on Congo red-stained specimens, we recommend the combined use of elastic fiber staining and immunohistochemistry for EFEMP1 to prevent overlooking this deposition.
Cheiloscopic Evaluation in Forensic Odontostomatology: Exploring Potential and Limitations
Authors: Di Vita Emanuele , Albano Davide , Trizzino Andrea , Sciarra Fabio Massimo , Vintrici Simone , Reali Lorenzo , Cumbo Enzo , Bilello Giuseppa , Zerbo Stefania , Argo Antonella , Messina Pietro , Scardina Giuseppe Alessandro
Published: June 2024

Background: The aim of this experimental work was to evaluate cheiloscopy potential: to confirm the individual uniqueness of lip prints, to verify the presence of recurrent patterns according to the Suzuki and Tsuchihashi classification and to search for characteristics that can be used in establishing the sex of a subject, with a focus on assessing the method's limitations. Methods: Lip prints were taken from a sample of 172 volunteers using liquid lipstick and transparent adhesive tape and were digitally analyzed. Results: 59 prints (35.3%) were not considered for Suzuki and Tsuchihashi classification due to quality errors and the impossibility of visualizing lip wrinkles in one or more sextants. All the digitized prints revealed themselves to be unique after having been analyzed using superimposition. Qualitatively valid prints indicated a prevalence of Type II in both male and female. A major problem was that the analysis of the same print by different operators often resulted in a different attribution of a Type. Conclusions: The potential of cheiloscopy lies mainly in the matching of prints, given their uniqueness, but the absence of a database greatly limits its use. Additionally, its use for sex identification does not seem to be reliable. It is necessary to establish an acquisition protocol for taking and analyzing prints that could reduce the errors committed by the operator.
Temporal Dynamics of Plasma Catecholamines, Metabolic and Immune Markers, and Corticosterone: DHEA Ratio in Farmed Crocodiles Before and After an Acute Stressor
Authors: Swanepoel Andre , Truter Christoff , Viljoen Francois , Myburgh Jan , Harvey Brian
Published: June 2024

Commercial crocodilian farms face significant economic and livestock losses attributed to stress, which may be linked to their adopted husbandry practices. The development of appropriate and modernized husbandry guidelines, particularly those focused on stress mitigation, is impeded by the limited understanding of the crocodilian stress response. Fifteen grower Nile crocodiles were subjected to simulated acute transport stress, with blood samples collected at various intervals post-stress. Plasma levels of corticosterone, dehydroepiandrosterone (DHEA), adrenaline, and noradrenaline were determined using high-performance liquid chromatography. Glucose and lactate were measured using portable meters, and the heterophil-to-lymphocyte ratio (HLR) was determined via differential leucocyte counts. Significant differences were elicited after the stressor, with acute fluctuations observed in the fast-acting catecholamines (adrenaline and noradrenaline) when compared to baseline. Downstream effects of these catecholamines and corticosterone appear to be associated with a persistent increase in plasma glucose and HLR. Lactate also showed acute fluctuations over time but returned to baseline by the final measurement. DHEA, used as a ratio with corticosterone, showed fluctuations over time with an inverted release pattern to the catecholamines. The study highlights the temporal dynamics of physiological markers under acute stress, contributing to understanding crocodilian stress and potentially informing improved farming practices for conservation and sustainable management.
Optimization of Energy Efficiency, Operation Costs and Carbon Footprint Using Pareto Analysis with New Generation Ro Membranes for Sea Water Desalination Plants
Authors: Chirinza Nicolau , Muguirrima Paulino , Zerpa Federico A. Leon , Ramos-Martin Alejandro , Perez-Baez Sebastian , Mendieta-Pino Carlos Alberto
Published: June 2024

This study explores the potential of piloting desalination plants in a systematic way to evaluate energy improvements in water desalination processes. Pilot tests with the latest generation of reverse osmosis membranes in large desalination plants are becoming increasingly common, as small-scale experiments are carried out on the operation of new generation membranes with better salt rejection and lower energy consumption. This approach aims to achieve optimal water quality standard at the lowest possible cost. In this way, pilot tests are being carried out before the decision is made whether to change the reverse osmosis membranes, as this represents a significant investment. By carrying out these tests, we hope to minimize the risk of making a mistake to ensure the best results in terms of energy consumption, operating costs and reducing the environmental impact while complying with the required water quality. In this case, the Pareto analysis is used to identify the two or three most significant causes whose treatment affects more than 80% of the possible energy improvement to be implemented. This article introduces a novel approach to studying a total of 180 desalination plants at the territorial level in the Canary Islands. The global scarcity of freshwater resources has greatly contributed to the development of desalination technologies, in which reverse osmosis is one of the most widely used and highly regarded methods.
Natural Fiber-reinforced Mycelium Composite for Innovative and Sustainable Construction Materials
Authors: Voutetaki Maristella E. , Mpalaskas Anastasios C.
Published: June 2024

Fiber-reinforced mycelium (FRM) composites offer an innovative and sustainable approach to construction materials for architectural structures. Mycelium, the root structure of fungi, can be combined with various natural fibers (NF) to create a strong and lightweight material with environmental benefits. Incorporating NF like hemp, jute, or bamboo into the mycelium matrix enhances mechanical properties. This combination results in a composite that boasts enhanced strength, flexibility, and durability. Natural FRM composites offer sustainability through the utilization of agricultural waste, reducing the carbon footprint compared to conventional construction materials. Additionally, the lightweight yet strong nature of the resulting material makes it versatile for various construction applications, while its inherent insulation properties contribute to improved energy efficiency in buildings. Developing and adopting natural FRM composites showcase a promising step towards sustainable and eco-friendly construction materials. Ongoing research and collaboration between scientists, engineers, and the construction industry will likely lead to further improvements and expanded applications. This article provides a comprehensive analysis of the current research and applications of natural FRM composite for innovative and sustainable construction materials. Additionally, the paper reviews the mechanical properties and potential impacts of these natural FRM composites in the context of sustainable architectural construction practices. Recently, the relevance of mycelium-based materials has extended beyond their original fields of microbiology and mycology to architecture.
Sustainable Sludge Management in China: Quantifying GHG Emissions and Exploring Its Reduction Strategies
Authors: Hu Dongming , Jiang Peng , Chen Yipei , Gao Fuyao , Liu Shuai
Published: June 2024

This study aims to quantify greenhouse gas (GHG) emissions from China's sludge treatment industry and explore the potential of novel technologies to mitigate these emissions, promoting sustainable sludge management practices. Using a life cycle assessment approach, the total GHG emissions from sludge treatment in 2017 were estimated at 18.54 Mt CO2-eq, with significant regional variations. Incineration contributed the highest emissions (1,011.53 kg CO2-eq/t dry sludge), followed by landfill (717.51 kg CO2-eq/t) and land application (276.41 kg CO2-eq/t). The uneven distribution of emissions across cities highlights the need for targeted mitigation strategies that consider local sustainability challenges. Principal component analysis revealed that economic factors and treatment scale significantly influence emissions, emphasizing the importance of integrating sustainability goals with economic development. To reduce the carbon footprint of sludge treatment and enhance sustainability, the mitigation potential and costs of various technologies were evaluated, including thermal conversion, anaerobic digestion, hydrothermal processes, and wet oxidation. These technologies offer GHG emission reductions ranging from 0.09 to 0.46 t CO2-eq/t dry solids compared to conventional methods, while also promoting resource recovery and circular economy principles. However, further optimization is necessary to enhance their environmental and economic performance, ensuring long-term sustainability. By implementing these technologies and adopting optimization strategies, China's sludge treatment industry can significantly contribute to achieving the country's carbon neutrality goal and fostering sustainable development.
Collaborative learning using open-source FPGA-based under water ultrasonic system
Authors: Lemaire Etienne , Busseuil Rémi , Chemla Jean-Paul , Certon Dominique , Zambelli Cristian , Cruz de la Torre Carlos , Gardel Vicente Alfredo , Bravo Ignacio , Mendonça Hélio , Alves José Carlos
Published: June 2024

The Digital electronics collaborative enhanced learning (DECEL) project has recently developed an international collaborative education course. Its main objective is to enhance the digital electronics skills of international students by working on a complex, multidisciplinary applied problem using a mixed digital architecture. We have developed a logic level synthesis and dedicated software layers on the Red Pitaya FPGA platform. The diversity of digital concepts to be implemented, from hardware description language (HDL) to high-level languages such as Python or Matlab, forced the students to work together and rapidly improve their skills. Their motivation was fueled by the curiosity of controlling an ultrasound probe to obtain ultrasound signatures. This particular physics, little known to the students, was an additional source of curiosity. The goal of forming an image in a liquid medium was an additional motivating factor for them. The students reported that they learned a lot from the experiment. Thus, the technical parts and pedagogical results are documented in this work for reproducibility.
Deep Learning for Early Disease Detection: A CNN Approach to Classify Potato, Tomato, and Pepper Leaf Diseases
Authors: Sarawagi Karan , Dhiman Hardik , Pagrotra Ashutosh , Talwandi Navjot Singh
Published: June 2024

Early disease detection is crucial for maximizingcrop yields and minimizing financial losses in agriculture. Inorder to categorise leaf diseases in pepper, tomato, and potato plants, this study suggests a revolutionary CNN design. The algorithm collects disease-specific features from input photos by using data augmentation techniques to artificially enlarge the training dataset. ReLU-activated convolutional layers gradually capture features at different levels, from low to high, while max pooling layers minimise spatial dimensionality. After thecharacteristics are extracted, a fully-connected layers with a softmax activation function classify them into illness groups. A well chosen dataset containing labelled healthy and sick leaves is used to train and validate the model. Generalizability to untesteddata is ensured via performance evaluation on an independent testing set. The field of deep learning for agricultural applications benefits from this research. This strategy has the ability to rev- olutionise agricultural practices by enabling automated disease identification. This might result in early interventions, better crop health, and eventually sustainable agricultural production.
Developing Expert Systems for Improving Energy Efficiency in Manufacturing: A Case Study on Parts Cleaning
Authors: Ioshchikhes Borys , Frank Michael , Elserafi Ghada , Magin Jonathan , Weigold Matthias
Published: June 2024

Despite energy-related financial concerns and the growing demand for sustainability, many energy efficiency measures are not being implemented in industrial practice. There are a number of reasons for this, including a lack of knowledge about energy efficiency potentials and the assessment of energy savings as well as the high workloads of employees. This article describes the systematic development of an expert system, which offers a chance to overcome these obstacles and contribute significantly to increasing the energy efficiency of production machines. The system employs data-driven regression models to identify inefficient parameter settings, calculate achievable energy savings, and prioritize actions based on a fuzzy rule base. Proposed measures are first applied to an analytical real-time simulation model of a production machine to verify that constraints required for the specified product quality are met. This provides the machine operator with the expert means to apply proposed energy efficiency measures to the physical entity. We demonstrate the development and application of the system for a throughput parts cleaning machine in the metalworking industry.
Evaluation of Epidemiological and Pathological Features of Symptomatic Spinal Metastases in Romania—What Could We Learn from a Retrospective Study?
Authors: Șelaru Ștefan , Eva Lucian , Sava Anca , Dumitrescu Gabriela Florența , Dabija Marius Gabriel , Poroch Vladimir , Knieling Anton , Dima-Cozma Lucia Corina , Tomaziu-Todosia Mihaela , Dumitrescu Ana Maria , Stan Cristinel Ionel , Scripcariu Viorel
Published: June 2024

Background and Objectives: Metastases are the most common tumors of the spine. As an important increase in the annual incidence of spinal metastases (SM) has been observed in the last decade, the aim of this study was to describe the epidemiology and histopathological types of SM surgically treated in the neurosurgery clinics of a regional hospital in North-Eastern Romania over a period of 5 years, in order to define a certain tumor profile that would benefit from an early screening. Materials and Methods: We retrospectively evaluated 115 adult patients, searching for demographic data (gender and age of the patients), primary tumor characteristics (location and histological type), topography and histopathological type of the spinal metastasis, and the time interval between the diagnosis of the primary tumor and the surgery for the spinal metastasis. Results: The patients were elderly (average age = 58.96 years), with a male predominance (67.82%). Main location of SM was in thoracic region (44.34%), with multiple vertebral metastases in 30.43% patients. Only 33.04% of the patients had a known cancer at the time of admission. Primary tumor was located mainly in lung (47.82%), gastrointestinal tract (15.65%), breast (11.30%), prostate (10.43%) and kidney (9.56%). SM from lung cancer mostly expressed squamous cell carcinoma (19.13%), and those from the digestive system mostly exhibited a moderately/poor colorectal adenocarcinoma (8.69%). Conclusions: Our data suggest the need for close surveillance of patients diagnosed with lung cancer and colorectal cancer because these malignancies most frequently develop spinal metastases. Smoking prevention actions and screening programs for the detection and removal of precancerous colorectal lesions must be developed and expanded.
Consequences of Immunoglobulin Domain-Containing Protein Retro-Proteins
Authors: Terry Mason , Hurtado Andre , Mendoza Christopher , Vargas Logan , Davila Israel , Steele Truman , Gonda Amber , Mizrachi Dario
Published: June 2024

Amino acid sequences of native proteins are generally not palindromic. The protein molecule obtained as a result of reading the amino acid sequence backwards, i.e., a retro-protein, having the same amino acid composition and the same hydrophobicity profile as the native sequence may behave as a different molecule. Here we have used R4, a directed evolution product of Scfv-13, a protein that binds β-galactosidase, and report the properties of the retro-R4 (rR4). rR4 remains a binding protein and its new target is Glutamine-fructose-6-phosphate aminotransferase (GLMS), a native E. coli protein. Additionally, a tight junction immunoglobulin domain- containing membrane protein, junctional adhesion molecule A (JAMA) retro-protein retains the ability to drive cell-cell interactions. Thus, protein engineering suggests a new potential application to retro-proteins of the immunoglobulin superfamily.
The Impact of Digital Economy on Green Total Factor Produc-Tivity: Empirical Analysis Based on 114 Resource-Based Cities
Authors: Zheng Minggui , Luo Laiwen , Wen Donghong
Published: June 2024

Based on the panel data of 114 Chinese resource-based cities from 2013 to 2022, this paper uses principal component analysis, Super-SBM and Malmquist index to measure the development level of digital economy and green total factor productivity of resource-based cities, and empirically studies the impact of digital economy on The impact effect and mechanism of green total factor productivity in resource-based cities. The research found that: (1)From 2013 to 2022, the overall green total factor productivity of resource-based cities in my country showed a trend of first decline and then an upward trend; (2) Digital economy can promote the improvement of green total factor productivity of resource-based cities, and digital economy has more long-term effects than short-term effects. (3)Mechanism analysis shows that energy efficiency and industrial struc-ture optimization are important paths for the digital economy to promote green total factor productivity in resource-based cities. (4)Heterogeneity research shows that digital economy has the largest effect on green total factor productivity in mature cities and the least effect on growth cities; From a regional perspective, the digital economy has the greatest effect on promoting re-source-based cities in the eastern region, followed by the central region, and the western region is weaker.
Subacute Rumen Acidosis in Greek Dairy Sheep: Prevalence, Impact, and Colorimetry Management
Authors: Voulgarakis Nikolaos , Gougoulis Dimitrios , Psalla Dimitra , Papakonstantinou Georgios I. , Katsoulis Konstantinos , Angelidou-Tsifida Mariana , Athanasiou Labrini V. , Papatsiros Vasileios G. , Christodoulopoulos Georgios
Published: June 2024

Subacute rumen acidosis (SARA) is a prevalent issue in intensive livestock farming, particularly associated with high-concentrate diets. This study investigates the prevalence and impact of SARA in Greek dairy sheep farming and explores the use of computerized rumen colorimetry as a management and diagnostic tool for SARA in dairy sheep farms. Forty-two dairy sheep flocks were monitored regularly for rumen pH, milk composition, and milk yield over an approximately 9-month milking period. Computerized Rumen Mucosal Colorimetry was applied to 280 culled, aged ewes from these farms, with rumen wall samples taken for histological examination. SARA cases were identified in 19 farms (45%, n=48). Farms with SARA cases had lower milk fat levels, although milk yield was higher in these farms, while milk protein levels did not differ based on the SARA status of the farms. In culled ewes, rumen color was significantly associated with the farm's SARA status. Additionally, ewes from farms with more SARA cases exhibited increased thickness in the ruminal epithelium layers, particularly in the non-keratinized and total epithelium layers. In conclusion, SARA is a common disorder in the Greek dairy sheep industry, lowering the fat content of milk. The study suggests that computerized rumen epithelium colorimetry in aged culled ewes shows promise as a diagnostic tool for SARA in dairy sheep farms.
Metabolic Shift and Increased Osmotic Pressure Underlie Age-Related Macular Degeneration: A Review
Authors: Schwartz Laurent , Schwartz Jules , Hnery Marc , Bakkar Ashraf
Published: June 2024

In our previous papers, we demonstrated that inflammation and aging are the common roots of cancer and Alzheimer’s disease (AD). In both diseases, there is an inhibition of the mitochondria. In cancer, the alkaline intracellular pH (pHi) is associated with cell proliferation; acidic pHi causes apoptosis in AD. This difference is because cancer feeds on chemically neutral glucose, while neurons feed on acidic lactic acid. Increased uptake of lactic acid is responsible for acidic pH and cell death. Similarly, to AD, inflammation is responsible for metabolic shifts in age-related macular degeneration (AMD). In AD, there is hyperosmolarity responsible for increased lactic secretion by glial cells. Increased lactic secretion will cause neo-angiogenesis and neural cell death. Drugs increasing hyperosmolarity (Polyethylene Glycol) cause neo-angiogenesis and drusen-like structures in rodents. The link between AMD and inflammation is reinforced by the fact that treatments aiming at restoring mitochondrial activity, such as lipoic acid and/or methylene blue, have been experimentally shown to be effective in each set of diseases. The role of osmolarity has been demonstrated in the pathologies of the anterior segment of the eye, such as dry eye, corneal ulceration, cataracts, and glaucoma. The role of increased osmolarity in age-related macular degeneration (AMD) has been largely overlooked. We herein suggest that metabolic shift, inflammation, and hyperosmolarity are key players in the pathogenesis of AMD.
Using Behavior-Driven Development (BDD) for Non-functional Requirements
Authors: Santos Shexmo , Pimentel Tacyanne , Rocha Fabio Gomes , Soares Michel
Published: June 2024

Context: In Software Engineering, there must be clarity in communication among interested parts to elicit the requirements aimed at software development through frameworks to achieve the behaviors expected by the software. Problem: Lack of clarity in the requirements elicitation stage can impact subsequent stages of software development. Solution: We proposed a case study to achieve the proposed goal focusing on the performance efficiency characteristic expressed in the ISO/IEC/IEEE 25010 Standard using Behavior-Driven Development (BDD). Method: The case study was performed with professionals who use BDD to elicit the non-functional requirements of a company that develops software. Summary of Results: The results obtained were aspects related to the elicitation of non-functional requirements aimed at the performance efficiency characteristic of the ISO/IEC/IEEE 25010 Standard using BDD through the point of view of industry professionals. Contributions and impact: The article’s main contribution is to demonstrate the effectiveness of using BDD to elicit non-functional requirements about the performance efficiency characteristic of the ISO/IEC/IEEE 25010 Standard.
The Mental Health Index across the Italian Regions in the Esg Context
Authors: Resta Emanuela , Logroscino Giancarlo , Tafuri Silvio , Peter Preethymol , Chiara Noviello , Costantiello Alberto , Leogrande Angelo
Published: June 2024

The following article analyses the relationship between the mental health index and the variables of the Environment, Social and Governance-ESG model in the Italian regions between 2004 and 2023. The econometric analysis is aimed at investigating in detail the relationships between the mental health index and the individual components of the ESG model. The results are critically discussed
Moderate Aerobic Exercise Induces the Homeostatic IgA Generation in Senile Mice
Authors: Hernández-Urbán Angel Joel , Drago-Serrano Maria-Elisa , Reséndiz-Albor Aldo Arturo , Sierra-Ramírez José Alfredo , Guzmán-Mejia Fabiola , Oros-Pantoja Rigoberto , Godinez-Victoria Marycarmen
Published: June 2024

T-cell independent (TI) pathway activated by microbiota results in the generation of low-affinity homeostatic IgA with a critical role in intestinal homeostasis. Moderate aerobic exercise (MAE) provides a beneficial impact on intestinal immunity but the action of MAE on TI-IgA generation under senescence conditions is unknown. This study aimed to determine the effects of long-term MAE on TI-IgA production in young (3 months old) BALB/c mice exercised until adulthood (6 months) or aging (24 months). Lamina propria (LP) from the small intestine was obtained to determine B cells and plasma cells sub-populations by flow cytometry and molecular factors related to class switch recombination (TSLP/APRIL/BAFF/iNOS/RDH) and synthesis of IgA (α-chain/IL-6/IL-21/TGF-β); and epithelial cells to evaluate IgA-transitosis (pIgR/TNFα/IFN-/IL-4), by RT-qPCR technique. Results were compared with data obtained from sedentary age-matched mice. Statistical analysis was computed with ANDOVA and P<0.05 was considered as statistically significant difference. Under senescence conditions MAE promoted the B cell and IgA+B cells and APRIL that may im-prove the intestinal response and ameliorated the inflammatory environment associated pre-sumably with the downmodulation of pIgR. Data suggested that MAE improved the IgA and downmodulate the cytokine pro-inflammatory expression favoring homeostatic conditions in aging.
Ab Initio Molecular Dynamics Insight to Structural Phase Transition and Thermal Decomposition of InN
Authors: Piechota Jacek , Krukowski Stanislaw , Sadovyi Bohdan , Sadovyi Petro , Porowski Sylwester , Grzegory Izabella
Published: June 2024

Ab initio density functional theory molecular dynamics extensive calculations were used for the first time to evaluate stability conditions for relevant phases of InN. In particular, thermal decomposition of InN with formation of N2 molecules and pressure induced wurtzite – rocksalt solid-solid phase transition were established. The results consistent with available experimental data allowed a critical evaluation of potential and limitations of the proposed simulation method. The ab initio molecular dynamics as an efficient tool for simulations of phase transformations of InN including solid-solid structural transition and thermal decomposition with formation of N2 molecules has been demonstrated. It is of high interest because InN being important component of epitaxial quantum structures has still not been obtained as a bulk single crystal making difficult a determination of its basic physical properties and designing new applications.
The Role of Whole-Gland and Focal Cryotherapy in Recurrent Prostate Cancer
Authors: Pio Faozia , Murdock Andeulazia , Fuller Renee E. , Whalen Michael J.
Published: June 2024

Prostate cancer is the most common non-cutaneous malignancy in men, with the majority of newly diagnosed patients eligible for active surveillance. Despite definitive treatment, a considerable percentage of men will experience biochemical recurrence and even regional and distant metastatic recurrence after radiation therapy or radical prostatectomy. Salvage prostatectomy, while oncologically effective, poses significant morbidity with poor functional outcomes. Salvage cryotherapy has emerged as a promising alternative for localized recurrence, demonstrating safety and efficacy. This review examines the oncologic and functional outcomes of whole-gland and focal salvage cryotherapy, including disease-free survival, cancer-specific survival, and overall survival. The crucial role of multiparametric prostate MRI and evolving role of next-generation PSMA-targeted PET imaging is also examined. Comparison of outcomes of cryotherapy to other salvage ablation modalities, such as high-intensity focused ultrasound (HIFU) is also explored.
MR protocol optimization for Hepatobiliary Phase Imaging with Gadoxetic Acid for 1.5T: Comparison Between Breath-Hold T1-weighted and High Resolution Navigated 3D T1-weighted sequences
Authors: Picchi Eliseo , Ferrazzoli Valentina , Liberto Valeria , Toti Luca , Giocondo Raffaella , Da Ros Valerio , Pucci Noemi , Minosse Silvia , Garaci Francesco , Di Giuliano Francesca
Published: June 2024

Background and Objectives To compare navigator-gated three-dimensional T1-weighted gradient-echo sequences (NG-3D T1W-GRE) with standard breath-hold T1W-GRE (BH T1W-GRE) for the detection of HCC nodules in patients with chronic viral hepatitis which undergo at magnetic resonance imaging (MRI) using gadoxetic acid. Methods and materials We evaluated 58 patients with hepatic nodules at least 1 cm in diameter detected by ultrasound who underwent liver MRI including NG-3D T1W-GRE sequences and breath hold T1-weighted gradient-echo sequences with different flip angles(FA) at 10-25-40° after contrast administration of gadoxetic acid at magnetic scanner operating at1.5 Tesla. Image quality and relative hepatic and nodular enhancement were evaluated by three blinded reviewers. Results In these patients, image quality of NG-3D T1W-GRE was assessed significantly better than quality of BHT1W- GRE (P < 0.005) and relative enhancement was significantly higher than that of BH- T1W-GRE ( P
Critical Factors Affecting Outcomes of Endodontic Microsurgery: A Retrospective Japanese Study
Authors: Yamada Masashi , Kasahara Norio , Matsunaga Satoru , Fujii Rie , Miyayoshi Norihito , Sekiya Sayo , Ding Isabel , McCulloch Christopher A.
Published: June 2024

Keywords: Endodontic microsurgery; Root canal treatment; Isthmus preparation; Short-term outcomes
Monitoring Earthquake Risks in Nador, Northeast Morocco
Authors: Hlal Mohammed , Azmi Rida , Diop El Bachir , Adraoui Meriem , Abdem Seyid Abdellahi Ebnou , Serbouti Imane , Bounabi Mariem , Chenal Jérôme
Published: June 2024

Earthquake events present a high risk in urban areas. Nador City is a Mediterranean city located in a dynamic zone with seismologic movement and a frequency of earthquake events per year. This worrying rate shows that earthquake risks can hinder the urban area and damage citizens and goods if urban risk management is not taken. This study defines the areas most threatened by seismic events to protect them as a priority. Using Geographic Information System, Corine Land Cover, seismic intensity, and socioeconomic vulnerability index, we mapped the urban vulnerability index. The adopted model determines urban vulnerability levels from urban land cover, topography, geologic factors, and geomorphologic factors. These approaches reveal that $70\%$ of Nador is under the damage of a seismic disaster. In addition, the main objective is to apply a new set of guidelines to map the intensity of risks and explain the distinct risk exposure level in Nador’s urban context.
A New Methodology to Estimate the Early Age Compressive Strength of Concrete Before Demolding
Authors: Narantogtokh Bayarjavkhlan , Nishiwaki Tomoya , Takasugi Fumiya , Koyama Ken , Lehmann Timo , Jagiello Anna , Droin Félix , Ding Yao
Published: June 2024

Non-destructive testing has many advantages, such as the ability to obtain a large number of data without destroying existing structures. However, the reliability of the estimation accuracy and the limited range of applicable targets remains an issue. This study proposes to a novel pin penetration test method to determine the early age compressive strength of concrete before demolding. The timing of demolding and initial curing are determined according to the strength development of concrete. Therefore, it is important to determine the compressive strength at the early age before demolding at the actual construction site. The applicability of this strength estimation methodology at actual construction is investigated. Small test holes (12 mm in diameter) are prepared on the mold surface in real construction sites and mock-up specimens in advance. The pin is penetrated into these test holes to obtain the relationship between the compressive strength and the penetration depth. As a result, it is confirmed that the pin penetration test method is suitable to measure the early age compressive strength at actual construction site. This allows the benchmark values for compressive strength, necessary to avoid early frost damage, to be directly verified on the concrete structural members at the construction site. For instance, the compressive strengths of greater than 5 MPa and 10 MPa can be confirmed by the penetration depths benchmark values of 8.0 mm and 6.7mm or less, respectively.
To simple waves and small-amplitude perturbations in radiation gasodynamics
Authors: Kolesnichenko Aleksandr Vladimirovich
Published: June 2024

The paper analyzes one-dimensional simple waves and small-amplitude perturbations in radiating and scattering gray gas. The governing equation of radiation acoustics describing the dynamics of simple waves is derived. The conditions of radiation-thermal dissipation and radiation resistance force are introduced into this equation to describe the propagation with dissipation and attenuation of various radiation perturbation waves.
The phenomenological approximate Whitham method is used to investigate non-equilibrium wave phenomena in radiative medium. This method is an effective way to analyze fundamental modes when more than one velocity appears in the governing equation. The use of this method is demonstrated in this paper by considering the evolution of one-dimensional harmonic waves caused by a short-wave initial perturbation of the equilibrium state of the radiating and scattering medium. Analytical solutions are obtained for all wave modes, which allow us to interpret their physical meaning.
These solutions can be, in particular, an additional test for radiative hydrodynamic codes operating in the radiative acoustics regime. The presented approach may be useful in detailing higher-order numerical Godunov schemes for radiation acoustics problems.
LEVEREGING TECHNOLOGICAL HEREDITY TO INCREASE PRODUCTION EFFICIENCY OF FERROCERRAMIC PRODUCTS DURING FINAL MACHINING
Authors: Usov Anatoliy , Zaychyk Yuriy , Kunitsyn Maksym , Sikirash Yuliia
Published: June 2024

The quality state of grinded surface of ferro ceramic products is formed under the influence of thermomechanical phenomena which occurs during final machining and depends on the technological conditions for workpiece procurement. The mathematical model was formulated to regulate and optimize thermomechanical processes during the acquisition of ferroceramic workpieces. This mathematical model describes thermomechanical processes during workpieces sintering. Thermomechanical processes have a direct influence on defects formation in the workpieces. Grinding can cause the appearance of burns, cracks, tensile stresses in the surface layers of the products. These defects can significantly spoil the quality of products during their operation. High thermal stress of diamond-abrasive processing brings thermophysical aspects as a dominating factor for quality characteristics of processed surface. Existing grinding methods for products made from ferrocerramic materials are not able to fully eliminate the defects in the surface layer. Such defects are inherited from preceding machining operations, particularly from workpiece procurement. Material structure itself is prone or defect occurrence due to micro-heterogeneities, packaging defects, dislocations, and structural transformations. Analysis of the thermomechanical processes that run inside the surface layer made it possible to formulate calculation dependencies for defining technological conditions for eliminating burns and cracks during grinding of ferrocerramic products. Device for automatic stabilization of thermomechanical characteristics that accompany grinding of ferrocerramic products. This is achieved through the selection of optimal technological conditions for machining of the products that have heredity inhomogeneities inside the surface layer. Thus, this approach helps to achieve maximum efficiency within required quality citeria.
Oxygen uptake efficiency plateau is unaffected by fitness level - the NOODLE Study
Authors: Kasiak Przemysław , Kowalski Tomasz , Rębiś Kinga , Klusiewicz Andrzej , Sadowska Dorota , Wilk Adrian , Wiecha Szczepan , Barylski Marcin , Poliwczak Adam Rafał , Wierzbiński Piotr , Mamcarz Artur , Śliż Daniel
Published: June 2024

Background
Endurance athletes (EA) are an emerging population of focus for cardiovascular health. The oxygen uptake efficiency plateau (OUEP) is the levelling-off period of ratio between oxygen uptake (VO2) and ventilation (VE). In the cohort of EA, we externally validated prediction models for OUEP and derived with internal validation a new equation.
Methods
140 EA underwent a medical assessment and maximal cycling cardiopulmonary exercise test. Participants were 55% male (N=77, age=21.4±4.8 years, BMI=22.6±1.7 kg·m−2, peak VO2=4.40±0.64 L·min−1) and 45% female (N=63, age=23.4±4.3 years, BMI=22.1±1.6 kg·m−2, peak VO2=3.21±0.48 L·min−1). OUEP was defined as the highest 90-second continuous value of the ratio between VO2 and VE. We used the multivariable stepwise linear regression to develop a new prediction equation for OUEP.
Results
OUEP was 44.2±4.2 mL·L−1 and 41.0±4.8 mL·L−1 for males and females, respectively. In external validation, OUEP was comparable to directly measured and did not differ significantly. The prediction error for males was –0.42 mL·L−1 (0.94%, p=0.39), and for females was +0.33 mL·L−1 (0.81%, p=0.59). The developed new prediction equation was: 61.37–0.12·height (in cm) + 5.08 (for males). The developed model outperformed the previous and explained 12.9% of the variance (R= 0.377, R2= 0.129, RMSE= 4.39 mL·L−1).
Conclusion
OUEP is a stable and transferable cardiorespiratory index. OUEP is minimally affected by fitness level. The predicted OUEP provided promising but limited accuracy among EA. The derived new model is tailored for EA. OUEP could be used to stratify the cardiorespiratory response to exercise and guide training.