bluuebunny/crossref_metadata_2025 huggingface dataset:
Stromal immune cells expression of Siglec-15 is associated with lower T stage and better prognosis of urinary bladder cancer
Authors: Chu Chengbiao , Fu Yao , Yang Jun , Fan Xiangshan , Shi Jiong
Published: December 2024

Introduction

Sialic acid-binding immunoglobulin-like lectin 15 (Siglec-15) is a novel immune checkpoint, similar to programmed death-ligand (PD-L1), and has emerged as a potential target for cancer immunotherapy. Until recently, little was known about the expression and role of Siglec-15 in bladder cancer (BC).

Methods

In this study, we used immunohistochemical staining to assess the expression of Siglec-15 and PD-L1 in 69 primary BC samples and analyzed their relationship with clinicopathologic characters and prognosis.

Results

The expression rates of Siglec-15 in the tumor cells, stromal immune cells, and both the tumor and stromal cells were 84.1% (58/69), 50.7% (35/69), and 44.9% (31/69), respectively. The PD-L1 expression rate was 52.2% (36/69), with a positive rate of 17.4% (12/69). PD-L1 expression was inversely correlated with Siglec-15 expression, but the statistical significance was not achieved (P = 0.072). Low stromal Siglec-15 expression was associated with advanced tumor stage (P = 0.010). PD-L1 expression was associated with tumor stage (P = 0.008) and perineural invasion (PNI) (P = 0.048). Kaplan-Meier survival curves showed that stromal Siglec-15 expression was associated with a better prognosis (P = 0.012), although it was not an independent prognostic factor after multivariate analysis (P = 0.236) .

Discussion

This study revealed a high expression rate of Siglec-15 in BC and may provide valuable insights for patient selection in future clinical trials.
Identifying subtle differences : a radiomics model assessment for gastric schwannomas and gastrointestinal stromal tumors across risk grades
Authors: Yang Zimei , Ma Chongfei , Ren Jialiang , Li Min , Xv Xiaosheng , Fu Xin , Yang Li
Published: December 2024

Objective

This study aims to develop and validate an enhanced computed tomography (CT)-based radiomics model to differentiate gastric schwannomas (GS) from gastrointestinal stromal tumors (GIST) across various risk categories.

Methods

This retrospective analysis was conducted on 26 GS and 82 GIST cases, all confirmed by postoperative pathology. Data was divided into training and validation cohorts at a 7:3 ratio. We collected patient demographics, clinical presentations, and detailed CT imaging characteristics. Through univariable and multivariable logistic regression analyses, we identified independent predictors for discriminating between GS and GIST, facilitating the construction of a conventional model. Radiomic features were extracted and refined through manual 3D segmentation of venous phase thin-slice images to develop a radiomics model. Subsequently, we constructed a comprehensive combined model by integrating selected clinical and radiomics indicators. The diagnostic performances of all models in differentiating GS from GIST and stratifying GISTs according to malignancy risk were evaluated.

Results

We identified several key independent variables distinguishing GS from GIST, including tumor location, cystic changes, degree of enhancement in arterial phase, and enhancement uniformity. The conventional model achieved AUCs of 0.939 and 0.869 in the training and validation cohort, respectively. Conversely, the radiomics model, predicated on eight pivotal radiomics features, demonstrated AUCs of 0.949 and 0.839. The combined model, incorporating tumor location, degree of enhancement in arterial phase, enhancement uniformity, and a radiomics model derived rad-score, significantly outperformed the traditional approach, achieving AUCs of 0.989 and 0.964 in the respective cohorts. The combined model showed superior diagnostic accuracy in distinguishing GS from GIST, as well as GS from high or low malignancy potential GISTs, as evidenced by IDI values of 0.2538, 0.2418, and 0.2749 (P<0.05 for all).

Conclusion

The combined model based on CT imaging features and radiomics features presents a promising non-invasive approach for accurate preoperative differentiation between gastric schwannomas and gastrointestinal stromal tumors.
Temporal and spatial trends in gastric cancer burden in the USA from 1990 to 2021: findings from the global burden of disease study 2021
Authors: Zhan Chengwei , Qiu Binxu , Wang Jun , Li Yanhua , Yu Jinhai
Published: December 2024

Background

Gastric cancer (GC) is a significant public health concern in the USA, and its burden is on the rise.

Methods

This study utilized the latest data from the Global Burden of Disease (GBD) study. We provided descriptive statistics on the incidence, prevalence, mortality, disability-adjusted life years (DALYs), and age-standardized rates (ASRs) of GC across the USA and states. By calculating percentage changes and average annual percentage changes (AAPC), along with conducting age-period-cohort analysis, we assessed the trends in the burden of GC. Decomposition analysis was then performed, followed by the application of an autoregressive integrated moving average (ARIMA) model to forecast changes in ASRs through 2036.

Results

From 1990 to 2021, the number of incidence and prevalence of GC in the USA increased, but age-standardized incidence rates (ASIR) trended downward (AAPC = -0.73, 95% confidence interval [CI]: -0.77 to -0.68) and age-standardized prevalence rates (ASPR) (AAPC = -0.99, 95% CI: -1.08 to -0.9) showed a decreasing trend. In addition, the number of deaths, DALYs, age-standardized mortality rates (ASMR) and age-standardized DALYs rates (ASDR) in GC showed a decreasing trend. The burden of GC was significantly higher in males compared to females. In addition, we found that the highest incidence and prevalence in females was in the age group of 75-79 years, whereas the highest incidence and prevalence in males was in the age group of 70-74 years.

Conclusion

GC is a major public health issue in the USA. Although ASIR, ASPR, ASMR, and ASDR for GC are decreasing, the number of incidence and prevalence of GC in the USA remains high, and the disease burden of GC in the USA remains high. Strengthening preventive interventions, particularly for men and patients over the age of 60, will be crucial in the future.
Case report: Improving quality of life through hyaluronic acid-based fillers after orbital cancer treatment
Authors: Egidi Sara , Valentini Valentino , Schiavetti Amalia
Published: December 2024

Background

Myoepithelial carcinoma is a very rare yet aggressive tumor in children. Surgical intervention and local radiotherapy often lead to post-therapy complications, affecting both the aesthetic and functional quality of life in survivors. Hyaluronic acid (HA) dermal fillers offer a minimally invasive option to improve the appearance and quality of life for these patients once they are declared tumor-free.

Case presentation

We present the case of an 18-year-old girl with a history of myoepithelial carcinoma in the right upper orbit, diagnosed at the age of 8. The patient underwent surgery to remove the tumor and lacrimal gland, followed by chemotherapy and radiotherapy. A complete response to treatment was achieved, and the patient was monitored with regular clinical and radiological exams for 5 years, after which she was declared tumor-free and followed for late effects of therapy. Post-surgical radiotherapy resulted in atrophy of the upper orbital frame and functional complications. The patient exhibited upper eyelid retraction, ptosis, continuous lacrimation, and conjunctival redness. Ten years after treatment, the patient underwent dermal filler injections using Aliaxin® Essential Volume (AEV) and Aliaxin® Superior Volume (ASV) to address the aesthetic impairment of the upper right orbit. ASV was administered using a 22G x 50mm cannula on the periosteum of the superior orbital frame, entering from the outer canthus. AEV was injected with a cannula into the muscle, also entering from the outer canthus. Before treatment, the patient exhibited upper eyelid retraction, ptosis, continuous lacrimation, and conjunctival redness. Following the injections, improvements were observed in all pre-treatment symptoms. The closing ability of the upper eyelid was restored, along with superior orbital volume and symmetry. Enhanced eyelid function improved eye hydration, reduced redness in the conjunctiva, and led to better vision and overall quality of life.

Conclusion

To our knowledge, this is the first reported case of using dermal fillers to treat ocular changes resulting from cancer treatment. Injections of AEV and ASV provided both aesthetic and functional improvements.
Deep learning-based automation for segmentation and biometric measurement of the gestational sac in ultrasound images
Authors: Danish Hafiz Muhammad , Suhail Zobia , Farooq Faiza
Published: December 2024

Introduction

Monitoring the morphological features of the gestational sac (GS) and measuring the mean sac diameter (MSD) during early pregnancy are essential for predicting spontaneous miscarriage and estimating gestational age (GA). However, the manual process is labor-intensive and highly dependent on the sonographer's expertise. This study aims to develop an automated pipeline to assist sonographers in accurately segmenting the GS and estimating GA.

Methods

A novel dataset of 500 ultrasound (US) scans, taken between 4 and 10 weeks of gestation, was prepared. Four widely used fully convolutional neural networks: UNet, UNet++, DeepLabV3, and ResUNet were modified by replacing their encoders with a pre-trained ResNet50. These models were trained and evaluated using 5-fold cross-validation to identify the optimal approach for GS segmentation. Subsequently, novel biometry was introduced to assess GA automatically, and the system's performance was compared with that of sonographers.

Results

The ResUNet model demonstrated the best performance among the tested architectures, achieving mean Intersection over Union (IoU), Dice, Recall, and Precision values of 0.946, 0.978, 0.987, and 0.958, respectively. The discrepancy between the GA estimations provided by the sonographers and the biometry algorithm was measured at a Mean Absolute Error (MAE) of 0.07 weeks.

Conclusion

The proposed pipeline offers a precise and reliable alternative to conventional manual measurements for GS segmentation and GA estimation. Furthermore, its potential extends to segmenting and measuring other fetal components in future studies.
Reduced kidney size and renal function of high-grade vesicoureteral reflux and intrarenal reflux in contrast-enhanced voiding urosonography
Authors: Yan Hualin , Wu Cong , Zhou Jiehong , Huang Cairong , Ma Xue , Huang Yidong , Huang Lugang , Liu Juxian
Published: December 2024

Background

Vesicoureteral reflux (VUR) is a common pediatric urological condition associated with renal scarring, hypertension, and chronic kidney disease. Contrast-enhanced voiding urosonography (ceVUS) has emerged as a promising technique for diagnosing and evaluating VUR, with intrarenal reflux (IRR) often detected using this method. This study aimed to explore the relationship between different VUR grades and IRR on ceVUS, and assess the impact of VUR and IRR on kidney size and function.

Methods

We reviewed all ceVUS studies from January 2019 to December 2023 conducted at West China Hospital, Sichuan University. Both video clips and digital images of the ceVUS examinations were recorded. A total of 220 uretero-renal units (URUs) of 110 children (67 males and 43 females) were included in this study.

Results

Among the 220 URUs assessed, 134 were diagnosed with VUR, and 25 exhibited IRR, with IRR exclusively observed in patients with grade II VUR or higher. Upon age and sex matching, the severity of IRR showed a significant positive correlation with high-grade VUR (P < 0.001). Notably, patients with high-grade VUR and IRR displayed reduced kidney size compared to those without VUR or IRR (P < 0.05). Furthermore, patients with high-grade VUR and IRR had reduced DMSA renal function (P = 0.015, P = 0.012, respectively), and patients with high-grade VUR had more DMSA scars (P = 0.027), compared with those without VUR or IRR.

Conclusion

Our study highlights that on ceVUS, the IRR degree was associated with the high-grade VUR, along with reductions in kidney size and renal function in patients with high-grade VUR and IRR.
Non-persistence with multiple secondary prevention medications for peripheral arterial disease among older hypertensive patients
Authors: Wawruch Martin , Petrova Miriam , Celovska Denisa , Alfian Sofa D. , Tesar Tomas , Murin Jan , Trnka Michal , Paduch Tomas , Aarnio Emma
Published: December 2024

Introduction

The benefit of secondary prevention in hypertensive patients with peripheral arterial disease (PAD) is based on continual simultaneous taking of statins, antiplatelet agents and antihypertensive agents, preferably angiotensin-converting enzyme inhibitors (ACEIs) or angiotensin receptor blockers (ARBs). Our study was aimed at a) the analysis of the extent of non-persistence with multiple medication classes, and b) identifying factors associated with the likelihood of non-persistence.

Methods

In our cohort study, 3,401 hypertensive patients (1,853 females and 1,548 males) aged ≥65 years treated simultaneously with statins, antiplatelet agents and ACEIs/ARBs and in whom PAD was newly diagnosed during 2012 were analysed. A patient was classified as non-persistent when he/she was non-persistent with at least one of the three analysed medication classes. The most important characteristics associated with the probability of non-persistence were identified using the Cox regression.

Results

At the end of the follow-up period (mean length 1.8 years), 1,869 (55.0%) patients (including 1,090 females and 779 males) were classified as non-persistent. In the whole study cohort, factors associated with non-persistence were female sex, atrial fibrillation, and being a new user of at least one of the analysed medication classes; in males, they were university education, atrial fibrillation, and epilepsy, and, in females, being a new user.

Conclusion

Identification of sex differences in factors associated with non-persistence makes it possible to determine the groups of patients in whom special attention should be paid to improving their persistence with a combination of medicines in order to ensure successful secondary prevention of PAD.
FBXW7 in gastrointestinal cancers: from molecular mechanisms to therapeutic prospects
Authors: Wang Wanqing , Liu Xue , Zhao Lingling , Jiang Kaipeng , Yu Ziyi , Yang Ruihan , Zhou Wenshuo , Cui Jiuwei , Liang Tingting
Published: December 2024

F-box and WD repeat domain-containing 7 (FBXW7), formerly known as hCdc4, hAGO Fbw7, or SEL10, plays a specific recognition function in SCF-type E3 ubiquitin ligases. FBXW7 is a well-established cancer suppressor gene that specifically controls proteasomal degradation and destruction of many key oncogenic substrates. The FBXW7 gene is frequently abnormal in human malignancies especially in gastrointestinal cancers. Accumulating evidence reveals that mutations and deletions of FBXW7 are participating in the occurrence, progression and treatment resistance of human gastrointestinal cancers. Considering the current therapeutic challenges faced by gastrointestinal cancers, elucidating the biological function and molecular mechanism of FBXW7 can provide new perspectives and references for future personalized treatment strategies. In this review, we elucidate the key molecular mechanisms by which FBXW7 and its substrates are involved in gastrointestinal cancers. Furthermore, we discuss the consequences of FBXW7 loss or dysfunction in tumor progression and underscore its potential as a prognostic and therapeutic biomarker. Lastly, we propose potential therapeutic strategies targeting FBXW7 to guide the precision treatment of gastrointestinal cancers.
Marine-derived polysaccharides: the potential agents against neurodegenerative diseases
Authors: Zhu Lin , Ren Yuqian , Zhang Shenghan , Guo Yunliang , Zong Jinbao , Liu Yingjuan
Published: December 2024

Neurodegenerative diseases are primarily characterized by the selective loss of neurons in the brain, leading to a significant and widespread global public health burden. Although numerous mechanisms underlying neurodegenerative diseases have been elucidated, effective therapeutic strategies are still being explored. Several drugs have been proposed to halt disease progression; however, they often come with severe side effects. Recently, polysaccharides have garnered considerable attention due to their antioxidant, anti-neuroinflammatory, anticholinesterase, and anti-amyloidogenic properties. The ocean contains a large number of animals, plants, algae and fungal species. Its rich sources and wide availability make the research on marine drugs become a hot topic. Recently, polysaccharides dominated by fucoidan and chitosan have been reported to inhibit the progression of neurodegenerative diseases in a variety of ways. In this review article, we provide a comprehensive summary of reported polysaccharides that intervene in neurodegenerative diseases with the aim of exploring their potential as therapeutic agents.
From laboratory to field: cross-domain few-shot learning for crop disease identification in the field
Authors: Yang Sen , Feng Quan , Zhang Jianhua , Yang Wanxia , Zhou Wenwei , Yan Wenbo
Published: December 2024

Few-shot learning (FSL) methods have made remarkable progress in the field of plant disease recognition, especially in scenarios with limited available samples. However, current FSL approaches are usually limited to a restrictive setting where base classes and novel classes come from the same domain such as PlantVillage. Consequently, when the model is generalized to new domains (field disease datasets), its performance drops sharply. In this work, we revisit the cross-domain performance of existing FSL methods from both data and model perspectives, aiming to better achieve cross-domain generalization of disease by exploring inter-domain correlations. Specifically, we propose a broader cross-domain few-shot learning(CD-FSL) framework for crop disease identification that allows the classifier to generalize to previously unseen categories and domains. Within this framework, three representative CD-FSL models were developed by integrating the Brownian distance covariance (BCD) module and improving the general feature extractor, namely metric-based CD-FSL(CDFSL-BDC), optimization-based CD-FSL(CDFSL-MAML), and non-meta-learning-based CD-FSL (CDFSL-NML). To capture the impact of domain shift on model performance, six public datasets with inconsistent feature distributions between domains were selected as source domains. We provide a unified testbed to conduct extensive meta-training and meta-testing experiments on the proposed benchmarks to evaluate the generalization performance of CD-FSL in the disease domain. The results showed that the accuracy of the three CD-FSL models improved significantly as the inter-domain similarity increased. Compared with other state-of-the-art CD-FSL models, the CDFSL-BDC models had the best average performance under different domain gaps. Shifting from the pest domain to the crop disease domain, the CDFSL-BDC model achieved an accuracy of 63.95% and 80.13% in the 1-shot/5-shot setting, respectively. Furthermore, extensive evaluation on a multi-domain datasets demonstrated that multi-domain learning exhibits stronger domain transferability compared to single-domain learning when there is a large domain gap between the source and target domain. These comparative results suggest that optimizing the CD-FSL method from a data perspective is highly effective for solving disease identification tasks in field environments. This study holds promise for expanding the application of deep learning techniques in disease detection and provides a technical reference for cross-domain disease detection.
Morpho-physiological and transcriptomic responses of field pennycress to waterlogging
Authors: Combs-Giroir Rachel , Shah Manesh B. , Chhetri Hari B. , Morgan Mallory , Prates Erica Teixeira , Townsend Alice , Phippen Mary E. , Phippen Winthrop B. , Jacobson Daniel A. , Gschwend Andrea R.
Published: December 2024

Field pennycress (Thlaspi arvense) is a new biofuel winter annual crop with extreme cold hardiness and a short life cycle, enabling off-season integration into corn and soybean rotations across the U.S. Midwest. Pennycress fields are susceptible to winter snow melt and spring rainfall, leading to waterlogged soils. The objective of this research was to determine the extent to which waterlogging during the reproductive stage affected gene expression, morphology, physiology, recovery, and yield between two pennycress lines (SP32-10 and MN106). In a controlled environment, total pod number, shoot/root dry weight, and total seed count/weight were significantly reduced in SP32-10 in response to waterlogging, whereas primary branch number, shoot dry weight, and single seed weight were significantly reduced in MN106. This indicated waterlogging had a greater negative impact on seed yield in SP32-10 than MN106. We compared the transcriptomic response of SP32-10 and MN106 to determine the gene expression patterns underlying these different responses to seven days of waterlogging. The number of differentially expressed genes (DEGs) between waterlogged and control roots were doubled in MN106 (3,424) compared to SP32-10 (1,767). Functional enrichment analysis of upregulated DEGs revealed Gene Ontology (GO) terms associated with hypoxia and decreased oxygen, with genes in these categories encoding proteins involved in alcoholic fermentation and glycolysis. Additionally, downregulated DEGs revealed GO terms associated with cell wall biogenesis and suberin biosynthesis, indicating suppressed growth and energy conservation. Interestingly, MN106 waterlogged roots exhibited significant stronger regulation of these genes than SP32-10, displaying a more robust transcriptomic response overall. Together, these results reveal the reconfiguration of cellular and metabolic processes in response to the severe energy crisis invoked by waterlogging in pennycress.
The daily minimum leaf turgor pressure can represent the water status of apple trees under drip irrigation
Authors: Chen Ruixia , Xu Quanyue , Wan Junliang , Jiang Nan , Ma Juanjuan , Zheng Lijian
Published: December 2024

Introduction

Accurate diagnosis of the water status of fruit trees is a prerequisite for precise irrigation. Measurement of leaf turgor pressure provides a means to explore the water utilization mechanisms of fruit trees and their responses to water stress. However, there are few studies on the use of daily minimum leaf turgor pressure (Ppmax) to indicate water information in apple tree.

Methods

We monitored Ppmax, stem flow rate (Vstem), leaf water potential, soil water, and the main meteorological factors under two drip irrigation levels (fully irrigated and under-irrigated) to elucidate the temporal dynamics of the daily leaf turgor minimum of apple trees and diagnose the water status of fruit trees.

Results

The results showed that soil water deficiency could reduce leaf turgor pressure and increase Ppmax. In both years, the signal intensity and sensitivity of Ppmax were better than those of Vstem, and the sensitivity was 3.31 and 2.94 times of Vstem, respectively. Compared to Ppmax, Vstem had a higher correlation with meteorological factors and was more affected by meteorological conditions, independent of irrigation treatment. Ppmax was significantly negatively correlated with soil and leaf water potential, and its correlation coefficient was 2.58–4.89 times higher than that between Vstem and both.

Discussion

These results not only enhance our understanding of the water regulation strategies employed by apple trees under drought conditions but also provide a theoretical foundation for developing efficient water-saving practices and precision irrigation strategies for fruit trees.
Protocol for the assessment of the development of pragmatic competencies in early childhood (PDP-PI)
Authors: Junquera Cristina , Zubiauz Begoña
Published: December 2024

Introduction

The design of a Protocol for the Assessment of the development of pragmatic competences in early childhood (PDP-PI) and the preliminary data obtained in a comparative study in 3–5-year-old school children are presented.

Methods

The design of the protocol is based on a model of global understanding of pragmatics that considers essential to include linguistic, intersubjective and social aspects in order to make an adequate assessment of development. Based on the taxonomies of communicative functions, four basic competencies are described (Interactional, Referential, Subjective and Figurative). These competencies make it possible to categorize most of the linguistic emissions in early childhood. The PDP-PI presents two novelties with respect to other assessment systems: (a) it allows detecting the degree of a skill development (not only the presence/absence), (b) it includes items to assess the comprehension of pragmatics. The PDP-PI was used with 40 students of kindergarten education, divided into three groups according to school year.

Results

The results- Duncan’s post-hoc test-confirm the existence of significant differences between the different age groups in all competencies, except for referential competence. Construct validity was assessed by means of an inter-rater test (Fleiss’ Kappa = 0.76; Krippendorff’s Alpha = 0.76), and content validity was assessed by analyzing the correlations between the four competencies of the protocol. Significant correlations were found between all the competencies, except the relationship between the Referential and Interactional competencies.

Discussion

The data obtained in this study are preliminary, but they show that there is an evolution in the management of pragmatic skills, throughout early childhood, toward more complex and context-appropriate interactions. It is necessary to advance in procedures that discriminate against this evolution to establish developmental profiles which favor the detection of pragmatic difficulties or disorders at early ages.
Combining pleasant Olfactory and BRAin stimulations in treatment-resistant depression (COBRA): study protocol for a randomized controlled trial
Authors: Imbert Laetitia , Neige Cécilia , Dumas Maylis , Bensafi Moustafa , Mandairon Nathalie , Brunelin Jérôme
Published: December 2024

Background

Anhedonia, including social, physical, and less-known, olfactory, stands as a core symptom of major depressive disorder (MDD). At the neurobiological level, anhedonia has been associated with abnormal activity within the reward system, suggesting a key role for dopamine. Repetitive Transcranial Magnetic Stimulation (rTMS) has emerged as an innovative treatment for alleviating depressive symptoms. Stimulation of the dorsolateral prefrontal cortex (DLPFC) has been shown to both improve anhedonia and induce dopamine release. Moreover, research suggests that the efficacy of rTMS is improved when applied to an activated brain network rather than at rest. Our goal is to induce a dual activation of the reward system using a combined rTMS protocol and an intervention based on pleasant odorant exposure known to stimulate this system.

Methods

In this randomized controlled trial, we propose to combine rTMS targeting the left DLPFC with pleasant odorant stimulation to alleviate depressive symptoms. A total of 80 patients with treatment-resistant MDD will be randomly assigned to two groups and will receive 50 sessions of either: 1- rTMS and hedonic olfactory stimulations, or 2- rTMS alone. We will conduct pre- and post-assessments measuring depression severity, physical, social, and olfactory anhedonia, as well as the connectivity and activity of brain regions involved in the pathophysiology of depression and the reward circuitry.

Discussion

This study may strengthen the development of more effective rTMS interventions and pave the way for the establishment of rTMS combined with olfactory training as a safe, effective, and easily accessible treatment for MDD patients. In addition, this study will contribute to a better understanding of the mechanisms and physiopathology of MDD.

Trial registration number

#NCT05661383.
The effect of transcranial Direct Current Stimulation on the Iowa Gambling Task: a scoping review
Authors: Salice Silvia , Antonietti Alessandro , Colautti Laura
Published: December 2024

Introduction

Among the tasks employed to investigate decisional processes, the Iowa Gambling Task (IGT) appears to be the most effective since it allows for deepening the progressive learning process based on feedback on previous choices. Recently, the study of decision making through the IGT has been combined with the application of transcranial direct current stimulation (tDCS) to understand the cognitive mechanisms and the neural structures involved. However, to date no review regarding the effects of tDCS on decisional processes assessed through the IGT is available. This scoping review aims to provide a comprehensive exploration of the potential effects of tDCS in enhancing decisional processes, assessed with the IGT, through the evaluation of the complete range of target cases.

Methods

The existing literature was analyzed through the PRISMA approach.

Results

Results reported that tDCS can enhance performance in the IGT and highlighted a pivotal role of the dorsolateral prefrontal cortex and the orbitofrontal cortex in risky and ambiguous decisions.

Discussion

Thus, tDCS over the brain regions identified improves the decisional processes in healthy subjects and patients, confirming its potential to enhance decision making in everyday contexts and deepen the neural correlates. Suggestions for further studies are provided to delve into decisional mechanisms and how to better support them.
‘Let it stay in the heart’: cultural and gendered experiences of distress among Syrian refugees in Jordan
Authors: Lambert Jessica E. , Abutaleb Hala , Odeh Rahaf , de Jong Joop
Published: December 2024

Objective

This study explored cultural and gendered experiences of distress among Syrian refugees in Jordan to inform mental health and psychosocial support services with the population. We sought to understand perceived causes of distress, salient expressions used to describe distress, and ways of coping.

Methods

Eight focus group discussions (FGDs) were conducted with adult Syrian refugees (four male, four female). Gender-matched Jordanian qualitative researchers facilitated the FGDs. Transcripts were analyzed in Arabic using thematic analysis and validated through a final review of translated data.

Results

Four key themes were identified related to participants’ experience of distress, perceived causes and consequences, and gender differences (and similarities) in expression and coping. Results also highlighted the complexity of terminology used, and challenges in rank ordering expressions as most salient.

Conclusion

Results hold implications for adapting mental health and psychosocial interventions with the population to be more gender sensitive and culturally relevant.
Telehealth in arts therapies for neurodevelopmental and neurological disorders: a scoping review
Authors: Reitere Ērika , Duhovska Jana , Karkou Vicky , Mārtinsone Kristīne
Published: December 2024

Background

Arts therapies, encompassing art therapy, music therapy, drama therapy, and dance movement therapy with the broader practice of expressive arts therapies, have demonstrated positive outcomes in the treatment of neurodevelopmental and neurological disorders (NNDs). Integrating arts therapies into telehealth has become increasingly important to improve accessibility for people with mobility impairments or those living in remote areas. This study aims to map the existing body of literature to provide an in-depth overview of telehealth in arts therapies for individuals with NNDs.

Methodology

This scoping review followed the PRISMA guidelines. Six databases were systematically searched, with 2,888 articles screened for eligibility. Inclusion criteria focused on primary research peer-reviewed articles in English that addressed telehealth arts therapies for NNDs.

Results

Seventeen telehealth studies published between 2009 and March 2024 were included, with a notable increase in publications after 2020. The studies covered various neurodevelopmental disorders, including autism spectrum disorders, attention deficit hyperactivity disorder (ADHD), Rett syndrome, and neurological disorders such as stroke, epilepsy, cerebral palsy, central nervous system (CNS) tumors, dementia, Alzheimer’s disease, Parkinson’s disease, spinal cord injuries, and mild cognitive impairment. Music therapy was the most widely studied modality. Interventions ranged from therapeutic singing and songwriting to virtual reality experiences. Different platforms and specialized virtual environments were used alongside pre-recorded sessions. Positive benefits included psychological enrichment, social connectivity, cognitive improvements, and brain changes, although some studies reported mixed or no significant effects in certain areas.

Conclusion

Telehealth in arts therapies significantly benefits individuals with NNDs, improving accessibility and providing psychological, emotional, social, and cognitive benefits. The positive benefits observed highlight the potential of these interventions to improve overall well-being and daily functioning. Future research may focus on high-quality qualitative studies and neuroimaging assessments to further validate the impact of telehealth arts therapies.
Touching at a distance: the elaboration of communicative functions from the perspective of the interactants
Authors: Héron Robin , Safin Stéphane , Baker Michael , Zhang Zhuoming , Lecolinet Eric , Détienne Françoise
Published: December 2024

Touch is an inherent part of human social interactions and the diversity of its functions has been highlighted in numerous works. Given the varied roles of touch, with technology-mediated communication being a big part of our everyday lives, research has been interested in enabling and enhancing distant social interactions with mediated touch over networks. Due to the complexity of the sense of touch and technological limitations, multimodal devices have been developed and investigated. In this article, we explore the use of mediated visual touch in distant social interaction. Adopting an interactionist and collaborative approach to human communication, we focus on the communicative functions of distant touch behaviours which interactants co-elaborate throughout their mediated interactions. For this purpose, we conducted an exploratory study placing five romantically involved couples in interaction, where each discussed shared biographical events via a video call, using mediated touch devices (producing vibration and coloured lights). Their interactions were recorded, and excerpts were presented to participants in interviews using a collective confrontation technique (participants are confronted with a recording of their activity and encouraged to comment on it). This technique allows a better understanding of the participants’ points of view on their use of the touch devices in context. Through analysis of the interviews, our results highlight: (1) a variety of visual-touch functions with a redistribution of functions mostly supported by other modalities of communication in face-to-face interactions, such as illustrating aspects of the ongoing conversation; (2) the visual-touch characteristics as well as the verbal, paraverbal and non-verbal indicators of the interactional context considered by the participants to make sense of the stimuli and; (3) the multifactorial and dynamic aspects of the co-elaboration process of the visual-touch functions, reaffirming the role of interactional context, combined with cultural and biographical knowledge, in the meaning making.
Hand hygiene, knowledge and training motivational drives: findings from a survey in a university hospital
Authors: Corbo Maria Incoronata , Wachocka Malgorzata , Pozzi Maddalena , Cioce Marco , Di Donato Michele , Raponi Matteo , Pascucci Domenico , Marziali Eleonora , Fantoni Massimo , Murri Rita , Vincenti Sara , Nuzzo Carmen , Vetrugno Giuseppe , Cambieri Andrea , Laurenti Patrizia
Published: December 2024

This study assessed healthcare workers’ (HCWs) knowledge and adherence to hand hygiene principles in a large Italian university hospital, focusing on identifying knowledge gaps and evaluating training effectiveness. A specifically designed 17-item questionnaire, based on the World Health Organization (WHO) Hand Hygiene Knowledge Questionnaire, was used to measure theoretical knowledge, the role of training, and the impact of experience. The survey had an 8% participation rate (542 responses from a total of 6,749 HCWs), with higher responses among nurses and doctors. Results showed moderate knowledge of hand hygiene protocols, averaging 74%, but revealed gaps in comprehension, particularly in the correct use of hand rub and post-contact sanitation. Logistic regression analysis identified significant predictors of knowledge and adherence, with professional characteristics such as professional qualifications and length of service influencing outcomes (p < 0.05). The findings confirm the strong correlation between hand hygiene knowledge and compliance in reducing healthcare-associated infections (HAIs). Continuous education and customized interventions, including targeted training and feedback, are essential for targeting weak points and improving adherence. These insights emphasize the importance of ongoing training and monitoring to enhance hand hygiene practices, promote a culture of patient safety, and, as a consequence, reduce the incidence of HAIs.
Environmental change and floods: the long-ignored effects of displacement on mental health
Authors: Akram Sara , Mushtaq Shama
Published: December 2024

Although climate change has received significant global attention, there has been a distinct disregard for the issue of psychological well-being. The elevated floods resulting from climate change have substantial impacts on both physical infrastructure and human well-being. This includes the coerced relocation of individuals from their homes, unemployment, setbacks, and the disruption of communities. The occurrence of significant displacement due to major natural disasters, such as the floods in Pakistan in 2022, is linked to varying degrees of anxiety ranging from moderate to severe. The aim of this research is to perform a comprehensive analysis of the topic by utilizing the available literature. The study aims to ascertain the correlation between floods, caused by environmental shifts, and their influence on mental well-being in Pakistan, specifically focusing on the experiences of susceptible communities. Vulnerable populations, including socioeconomically disadvantaged communities, the older adults, individuals with disabilities, and children, are particularly susceptible to the adverse effects of severe weather conditions. During natural catastrophes, individuals experience elevated levels of psychological, emotional, and physical stress, which subsequently amplifies their vulnerability to these detrimental consequences.
Effects of underweight, overweight, and obesity on the body growth of preschoolers
Authors: Chen Jiebo , Luo Dongmei , Fan Xue
Published: December 2024

Objective

This study aimed to investigate the impact of underweight, overweight, and obesity on the growth and development of preschoolers by comparing body shape characteristics across different weight statuses.

Methods

A total of 729 preschoolers (5.2 ± 0.83 years, 53.8% boys) from three kindergartens were assessed for 11 different body shape measurements. Two-way ANOVA was employed to examine BMI variations across different ages and sexes. Discriminant analysis was utilized to identify body shape measurements correlated with BMI, and one-way ANOVA was conducted to compare the body shape differences among preschoolers with varying BMI.

Results

(1) There was no significant interaction effect of gender and age on BMI (F = 1.602, p = 0.173). Additionally, neither the main effect of age (F = 1.461, p = 0.228) nor the main effect of sex (F = 0.905, p = 0.345) was significant. (2) The results of the stepwise discriminant analysis showed that chest circumference, calf length, calf circumference, foot length, and width between greater trochanters entered the discriminant model, with the three discriminant functions explaining 95.8, 3.1, and 1.1% of variance, respectively. (3) Compared to their normal-weight counterparts, obese preschoolers displayed significantly larger measurements in chest circumference, width between greater trochanters, calf circumference, calf length, and foot length (p < 0.05). Overweight preschoolers also exhibited larger chest and calf circumferences, and width between greater trochanters (p < 0.05), while underweight children showed lagging development in various body shape measurements (p < 0.05).

Conclusion

Variations in BMI were significantly correlated with preschoolers’ body shape which included chest circumference, calf length, calf circumference, foot length, and the distance between the greater trochanters. Overweight and obese preschoolers experienced faster body growth; conversely, underweight preschoolers often showed delayed growth. This underscores that the underweight group also merits attention and concern.
Community case study: Our Wave, an online platform to facilitate survivor disclosure of sexual assault and trauma recovery
Authors: Sinko Laura , Naidenko Olga V. , Michaelsen Brendan , Marzke Cassandra , Hart Madeline , Tweedie Brooke , Linton Kyle
Published: December 2024

This community case study introduces Our Wave, an online platform that provides a safe, anonymous space for survivors of sexual harm to share their stories, reflect on their healing journeys, and connect with others. Designed to empower survivors, the platform allows users to post anonymous stories or visual media, ask questions, and send messages of hope, all while prioritizing privacy and security. It also aims to create a broader impact by analyzing shared narratives to detect patterns, identify best practices for healing, and inform global approaches to SV recovery. With over 100,000 members and over 1,200 stories and forms of media shared, the platform has become a valuable resource for survivors. Using mixed-methods analysis of platform usage data and anonymous user feedback surveys (n = 288), we examined patterns of engagement and impact. Analysis revealed that 57% of story submissions included “Messages of Healing” and 52% included “Messages of Hope,” with survey responses indicating that anonymity and peer support were crucial factors in facilitating disclosure. Research shows that the social and emotional dynamics of SV disclosure, as well as the responses from others, play a crucial role in a survivor’s healing. By focusing on confidentiality, trauma-informed support, and community-building, Our Wave offers a safe space for survivors to heal, connect, and access resources to support their journey toward recovery.
Contagion comeback: unravelling the measles outbreak across the USA
Authors: Tahir Iman Muhammad , Kumar Vijay , Faisal Hanya , Gill Anosh , Kumari Vineeta , Tahir Haya Muhammad , Haque Md Ariful
Published: December 2024

Measles, a highly contagious respiratory illness caused by the measles virus (MeV), poses significant global and national public health challenges despite advancements in vaccination efforts. Though measles was declared eliminated in the United States in 2000, recent years have seen a resurgence of cases, particularly in under-vaccinated communities. This resurgence is compounded by factors such as vaccine hesitancy, the impact of the COVID-19 pandemic on immunization rates, and international travel introducing new cases from endemic regions. This paper examines the epidemiology and recent measles outbreaks in the United States, focusing on the significant rise in cases from 2020 to 2024. The analysis highlights the importance of maintaining high vaccination coverage, particularly in vulnerable populations, and explores the challenges of managing outbreaks. The study also reviews the pathophysiology, clinical presentation, diagnosis, and treatment of measles, emphasizing the role of prevention and control measures, including the MMR vaccine, public health interventions, and international cooperation in addressing this persistent threat.
Spatial heterogeneity and predictors of stunting among under five children in Mozambique: a geographically weighted regression
Authors: Tamir Tadesse Tarik , Tekeba Berhan , Mekonen Enyew Getaneh , Zegeye Alebachew Ferede , Gebrehana Deresse Abebe
Published: December 2024

Introduction

Childhood stunting, a major public health concern in many developing countries, is associated with impaired physical and cognitive development, increased risk of infectious diseases, and long-term adverse health and economic consequences. Mozambique is among the countries with the highest stunting rates in sub-Saharan Africa. This study aims to examine the spatial variation and identify the predictors of stunting among children under the age of five years in Mozambique.

Methods

We utilized children’s recode data and geographic coordinates extracted from the 2022–23 Mozambique Demographic and Health Survey dataset. A stratified two-stage cluster sampling approach was employed. The study included a total weighted sample of 3,910 children under the age of five years. A geographically weighted regression was used to identify predictors of stunting.

Results

The prevalence of stunting among children under the age of five in Mozambique was 31.26% (95% CI: 29.88 to 32.65%). The Nampula (46.00%), Cabo Delgado (43.79%), Manica (40.88%), Zambezia (38.27%), Niassa (35.52%), and Tete (34.85%) regions of Mozambique were identified as hotspot areas of stunting. Several factors were significantly associated with the spatial heterogeneity in stunting, where household wealth index (poor and middle categories) and Mother’s age (15–19 years) were positively associated with higher occurrence of stunting, while having an employed mother and being a child under 2 years of age were negatively associated with stunting occurrence.

Conclusion

The spatial heterogeneity in stunting patterns highlighted by this analysis suggests that a one-size-fits-all approach to address child undernutrition in Mozambique may not be effective. Instead, tailored, location-specific strategies that account for the predictors of stunting are necessary to effectively combat this persistent public health challenge. Policymakers and program implementers should prioritize the hotspot regions for targeted interventions, while also maintaining and strengthening the factors contributing to the lower stunting prevalence in the cold spot areas.