bluuebunny/crossref_metadata_2025 huggingface dataset:
Performance studies of constructed wetlands for treatment of wastewater under temperate climatic conditions
Authors: Harne Kailash , Joshi Himanshu
Published: December 2022

Phytoremediation also known as constructed wetlands is an effective method of treatment of municipal as well as industrial wastewater. The efficacy of this method has already been tested in European and American countries and found to be the best method of wastewater treatment. Efforts have been made in the present work to check the efficacy of phytoremediation in the form of constructed wetlands under Indian climatic conditions. A pilot plant of constructed wetlands has been constructed on the premises of the Uttaranchal Jal Nigam Sewage treatment plant and municipal wastewater has been allowed to pass through the constructed wetland. It has been observed that BOD removal at 24 0C is governed by the equation Ce/Co = e-1.0042 x t and the removal rate constant of BOD has been observed to be 0.795 d-1 at 20 0C. It has been observed that the pilot-scale constructed wetland is bringing effluent BOD and TSS up to 20 mg/l and 30 mg/l respectively consistently for the duration under study. The values of hydraulic retention time, hydraulic loading, and organic loading for achieving this performance are found to be 1.75 days,13.22 cm/d, and 142.78 kg/ha. d respectively. Performance study of constructed wetland and the existing activated sludge treatment has shown that the percent removal for the parameters TSS, BOD, COD, and Fecal Coliforms is near to the same order except for TN and TP, where the activated sludge process unit shows higher removal than the constructed wetland.
Quantifying the Sorptive Behavior of Traditional Horticultural Substrate Components Based on Initial Hydraulic Conditioning
Authors: Bartley Paul C. , Yap Ted C. , Jackson Brian E. , Fonteno William C. , Boyette Michael D. , Chaves-Cordoba Bernardo
Published: December 2022

The ability of a substrate component (organic or inorganic) to capture and retain water (hydration and wettability) is important to investigate and promote water-use–efficient practices. Many factors may play a role in the wettability of the material, including the processing of the material and its initial handling. The goal of this experiment was to determine the effect of moisture content (MC) on the sorptive behavior of substrates after an initial and secondary hydration cycle. Coir, peat, and aged pine bark were evaluated at a 33%, 50%, and 66% MC by weight. At all moisture levels, coir and bark were minimally affected by MC or the initial hydration cycle. Peat was the most vulnerable to changes in sorptive behavior as a result of wetting and drying cycles. After a wetting and drying cycle, the maximum volumetric water content of peat from surface irrigation was reduced 21.5% (volumetrically), more than three times any other treatment. The hydration efficiency of peat was improved when blended with as little as 15% coir. These experiments provide evidence that MC and initial handling of the substrate can lead to differences in initial water use efficiency.
Nature-inspired Material – A Step Ahead in Dental Materials
Authors: Kupka Tomasz "Tomi"
Published: December 2022

Glass-ionomer is first choice widely used biomaterial in caries disease. The evolution of dental material science includes insertion of new components into conventional material. A literature-based review outline of biomaterials for dental restorations development was presented in nature-inspired context. This article is a tribute to the entire research community, for all listed and unlisted, involved throughout the ages in the science of dental materials with the key inventions and milestones for humanity well-being on Earth. Results. Since the Neolithic, the human mind has been seeking for a matter to replace missing tooth tissue imitating/mimicking natural organ in appearance and function, what we call biomimetic/biomimicry approach. However, this restoring philosophy does not refer to the natural composition of hard tooth tissues. Possibly, there is another one concept of drawing inspiration from nature for the design of future dental materials. Nature-inspired synthesis goes beyond aesthetic/and anatomical similarities, and delves into the mechanistic, physico-chemical features or structure-phase of natural systems. In this context, pure glass-ionomer might be taken into consideration as a starting material. However, the search for synthetic nature-inspired mesomaterial with a structural-phase composition analogous to enamel/dentine/cementum, transforming into the original host hard tissues, should focus on elongated hydroxyapatite dipole control for creating and organizing into enamel prisms, and the interwoven alignment of perpendicular clusters/bunches in a picket-fence resembling three-dimensional order. The results of previous studies confirming the possibility of the formation of apatite-enamel-like tissue in glass-ionomer are promising. The concept of inclusion of calcium phosphate nanocrystals/substitution of glass filler seems to be forward-looking. The future role of polyelectrolyte organic matrix based on synthetic tooth polypeptides crosslinked with modified analogues of natural adhesives is still undiscovered.
TÜRK MİLLETLERARASI ÖZEL HUKUKUNDA DEVLETİN MİRASÇILIĞI
Authors: NALÇACIOĞLU ERDEN Hümeyra Zeynep
Published: December 2022

5718 sayılı Milletlerarası Özel Hukuk ve Usul Hukuku Hakkında Kanun’a göre, “miras ölenin milli hukukuna tâbidir. Türkiye’de bulunan taşınmazlar hakkında Türk hukuku uygulanır” (m.20/1). Maddede taşınır ve taşınmaz malvarlığı değerleri açısından ikili bir ayrım yapılmıştır. Buna göre, terekedeki taşınır malvarlığı değerleri ile Türkiye dışındaki taşınmaz malvarlığı değerlerine ölenin millî hukuku uygulanırken Türkiye’deki taşınmazlar için Türk hukuku uygulanır. Kimlerin mirasçı olacağı da bu hukuklara göre tayin edilir. Mirasbırakanın hiçbir mirasçısının olmaması durumunda ise, “Türkiye’de bulunan mirasçısız tereke Devlete kalır” (m.20/3). Bu çalışmada Türk devletinin mirasçısız tereke üzerindeki hakkının niteliğini tayin amacıyla sahipsiz mala son yasal mirasçı olarak mı yoksa egemenlik hakkına dayanılarak mı el konulduğu; miras statüsüne göre mirasbırakanın Türkiye’deki terekesine yabancı devletin yasal mirasçı olması ya da mirasbırakanın yabancı bir devleti Türkiye’de bulunan tereke için mirasçı ataması durumunda terekenin mirasçısız kabul edilip edilemeyeceği; yabancı devletin son yasal mirasçı olması ile yabancı devletin atanmış mirasçı olmasının, Türkiye’deki mirasçısız taşınır ve taşınmaz tereke açısından farklılık teşkil edip etmeyeceği ve yabancı kişilerin Türkiye’deki mirasçısız terekelerinin âkıbeti ele alınmış olup esas olarak yabancı devletin atanmış mirasçı olarak Türkiye’deki taşınır terekeyi iktisap edebileceği sonucuna varılmıştır.
Pathomorphological features of eyelid tissue scarring after treatment with platelet-rich plasma
Authors: Filatova I. A. , Pavlenko Yu. A. , Izmailova N. S. , Zharov A. A. , Shemetov S. A. , Ponomarev I. N. , Borovkova N. V.
Published: December 2022

Purpose: to evaluate the effectiveness of anti-scar treatment of eyelid tissues with platelet-rich plasma (PRP) lysate by pathomorphological examination. Material and methods. 20 patients (men aged 27–64 years with eyelid scars caused by traumatic tissue rupture) underwent reconstructive plastic surgery on their eyelids. All patients had similar injuries and traumatic agents, the type and localization of the scar, and the same duration of the post-traumatic period (12 months after the injury). The patients were divided into 2 groups depending on the application of anti-scar treatment using PRP lysate in the preoperative period. The treatment consisted in injecting a personalized biotransplant into the scar tissue. During the surgery, a fragment of scar tissue was taken from each patient for pathomorphological examination. Results. In the control group, the pathomorphological picture was of the same type and corresponded to the third phase of wound healing with remodeling and the formation of a rough scar. The third phase of wound healing with scar remodeling in patients of the main group was characterized by significantly less pronounced fibrotic-dystrophic changes in both cellular and stromal components of the dermis and hypodermis. Conclusion. In the main group with PRP lysate therapy, scar tissue was characterized by significantly less pronounced fibrotic-dystrophic changes in both cellular and stromal components of the dermis and hypodermis as compared to the control group. The observed morphological picture was close to a complete involution of the scar with its restructuring, approaching the normal histoarchitectonics of the dermis and hypodermis.
The biological effect of a combination of platelet lysate and amniotic membrane in buccal epithelium culture
Authors: Chentsova E. V. , Borovkova N. V. , Makarov P. V. , Bozhenko D. A. , Ponomarev I. N. , Storozheva M. V. , Makarov M. S.
Published: December 2022

Purpose: To study the biological effect of a combination of platelet lysate and amniotic membrane, preserved by various techniques, on human buccal epithelium culture. Materials and methods. Human amnion transplants were preserved using 3 methods: silicate drying, lyophilization, cryopreservation. The blood of healthy volunteers was used as a source of platelets. Platelet-rich plasma (PRP) with a platelet content over 1000 thousand/mcl and more was isolated from the donors blood, frozen at -80 °С and defrosted at 0–4 °С to prepare platelet lysate. Growth-stimulating effect of the amnion transplants was studied in different groups: control group 1 — without amnion and without PRP lysate; control group 2 — PRP lysate without amnion; experimental group 1 — amnion without PRP lysate; experimental group 2 — amnion samples combined with PRP lysate. The study was carried out on the example of human buccal epithelium culture of 3–5 passages. The dynamics of cell growth was evaluated after 1, 2 and 3 days from the moment of seeding. The number of cells and their viability were evaluated using original methods based on vital cell staining and their examination in a fluorescent microscope. Results. All samples of preserved amnions were non-toxic and did not damage the structural and functional characteristics of the buccal epithelium. On the other hand, the use of amnion without PRP lysate did not have a growth-stimulating effect on cells. Among the amnion samples combined with PRP lysate, the combination of lyophilized amnion and PRP lysate was the most effective during the entire study period. Conclusions. Silicate drying, lyophilization and cryopreservation of the amniotic membrane makes it possible to obtain biocompatible and non-toxic transplants, based on human amnion. Lyophilized amnions are the most optimal for saturating PRP lysate. The combination of lyophilized amnion and PRP lysate stimulates cell growth in vitro without violating their structural integrity.
Malignant eyelid tumors: epidemiology and clinical observation of patients in Moscow
Authors: Lerner M. Yu. , Steshenko O. N.
Published: December 2022

Purpose: to assess the prevalence of primary malignant eyelid tumors and their prognostic features based on the materials of the ocular oncology department, Moscow Ophthalmological Center. Materials and methods. We performed a retrospective analysis of 10-year array (2010–2019) of documents of the Moscow Cancer Register, reports of the ocular oncology department of the Moscow ophthalmological center, S.P. Botkin State Clinical Hospital, and case histories of outpatients with malignant eyelid tumors, residing in Moscow. Results. Malignant ocular tumors were diagnosed in 3650 people. Of these, 75.29 % were eyelid tumors (2748 people). The most common malignant tumor was basal cell carcinoma (89.19 %), which was morphologically diagnosed and over the ten years showed an incidence increase of almost a third. The occurrence rate grows with age, with the peak observed between 70 and 79 years of life. Most often, the lower eyelid (64%) and the inner corner (22.14 %) are affected. Less common are tumors located in the upper eyelid (12.21 %) and at the lateral canthus — 2.3 %. Over 80 % of the relapses occurred at the T2–T3 stages, while only 18.2 % were eyelid skin cancers treated at the T1 stage. Tumors located in the inner corner of the palpebral fissure recurred up to 3 times more often than differently localized eyelid tumors. Conclusion. Malignant eyelid tumors are the most common of malignant ocular neoplasms, claiming ¾ of them. Basal cell carcinoma is the most common type. The peak incidence falls upon the 7th and the 8th decades of life. An increase in the incidence of malignant tumors of the eyelids is observed. The special ophthalmic-oncological service facilitates the diagnostics, treatment and dispensary observation of patients after treatment, which contributes to the early detection of relapses.
Orbital rhabdomyosarcoma in children
Authors: Saakyan S. V. , Sklyarova N. V. , Tsygankov A. Yu. , Zhiltsova M. G. , Alikhanova V. R. , Tatskov R. A.
Published: December 2022

Purpose. To analyze the results of treatment and active monitoring the children with orbital rhabdomyosarcoma (RMS) with an emphasis on vital prognosis. Material and methods. We examined 32 children with RMS (18 boys, 14 girls) aged 2 months to 12 years, whose case history ranged from 1 week to 16 weeks (median, 5 weeks). The median follow-up was 60 months. The tumor was localized in the upper (n = 13), upper internal (n = 9), lower (n = 4), internal (n = 3), and external (n = 3) quadrants. The patients underwent primary surgical treatment: orbitotomy using transcutaneous (n = 26), transconjunctival (n = 2) and subperiosteal access (n = 4) followed by cytological, histological and immunohistochemical tissue verification in all cases. Results. The highest number of RMS cases was noted in in the 2- to 7-year-old group (66 % of patients). All patients were treated in in-patient settings. Complete macroscopic removal of tumor was performed in 17 cases, partial removal in 9 cases, and biopsy sampling in 6 cases. The embryonic type of RMS accounted for 87 % (n = 28), and the alveolar type, for 13 % (n = 6). In the postoperative period all children received combined therapy (systemic polychemotherapy and distant radiation therapy) in in-patient facilities of special oncological and radiological clinics. The survival rate of the whole group was 100%. In the long-term follow-up period (after 3 to 5 years), reconstructive surgeries were performed to correct ptosis and strabismus, and/or spectacle or prismatic correction of complex or mixed astigmatism. In cases of “dry” eye syndrome, conservative local therapy was offered. After orbital exenteration, ectoprosthesis procedures was applied. Conclusion. The analysis of our observations of 32 children with orbital rhabdomyosarcoma showed a 100 % survival rate, which testifies to the importance of timely diagnosis and combined treatment of the tumor.
Abortion Ban in English Social Media in 2022: Pragmatic Linguistics of Online Communications
Authors: Gnedash Anna , Katermina Veronika
Published: December 2022

The present research featured the conflict discourse of online communication in social networks on the topic of abortion ban. The empirical base included 3,000,000 Twitter messages in English. The sampling by keywords women and abortion covered the period from May 1 to July 31, 2022, which saw an outburst of online and offline civic activities regarding some national anti-abortion policies. The resulting web corpus of network linguistic data (datasets) was subjected to multidimensional analysis using such methods as Data Science, mathematical modeling, relational sociology, corpus analysis, discourse analysis, etc. All these procedures combined resulted in a multidimensional comprehensive analysis of the simulated English asynchronous multimodal discursive field in Twitter. The models made it possible to visualize online communications in social networks, as well as to describe the discourse of online communication between pro-choice and pro-life. The authors analyzed the pragmatic potential of network communities on the current political agenda. The method might help to identify the conflict potential that can evolve from online communication into offline socio-political actions.
Corporate Website as a Means of Image Cultivation: The Case of the Zhorin and Partners Bar Association, Moscow
Authors: Kondrat'eva Ol'ga , Rogozhnikova Svetlana
Published: December 2022

Corporate websites play an important role in cultivating the image of a successful law firm. The authors analyzed the website of Zhorin and Partners Bar Association, Moscow, to verify this hypothesis. Various structural elements were responsible for highlighting particular features of the firm and its employees, e.g., professionalism, success, high profile, etc. The site proved to be interactive and demonstrated an admirable ratio of static and dynamic content. The analysis revealed five strategies of positive image cultivation: the firm was described as accredited, authoritative, successful, and prestigious, sometimes in an exaggerated way. Each strategy had its own language means. The website of Zhorin and Partners demonstrated an elaborate structure, a well-structured content, a high-quality linguistic design, and a variety of communication strategies. All the elements of the website contributed to a positive image of the law firm and its public promotion.
Effect of chemical clogging on the permeability of weakly consolidated sandstone due to reinjection at different temperatures
Authors: Zhong Tao , Tian Hong , Zheng Jun , Dou Bin , Wang Yachao , Yang Zhongyan , Li Peng , Xiao Peng
Published: December 2022

While utilizing hydrothermal resources, it is necessary to reinject wastewater into the reservoir through reinjection wells to extract heat without mining groundwater. Chemical clogging is a serious problem in the process of reinjection. The precipitation of minerals can lead to reservoir clogging and the reduction of permeability. Therefore, to study the effect of chemical clogging on permeability, the weakly consolidated sandstone of the Neogene Guantao Formation geothermal reservoir in northern Shandong (Eastern China) was taken as the research object. A long-term thermal-hydro-mechanical-chemistry (THMC) coupling reinjection experiment was carried out. The results showed that when the temperature of wastewater was higher than 45 °C, there was a temporary phase of permeability enhancement in the first 10 min of reinjection. However, wastewater with higher temperatures would cause more chemical clogging eventually. XRD and ion analysis results showed that the precipitation of minerals was mainly potash feldspar, illite, calcite, and other carbonate minerals during reinjection. According to the characteristics of low-TDS wastewater in the Guantao Formation, it is recommended to adopt low-temperature wastewater reinjection and reduce the concentration of Ca2+ and Mg2+ in wastewater before reinjection.
Inversion-based identification of DNAPLs-contaminated groundwater based on surrogate model of deep convolutional neural network
Authors: Miao Tiansheng , Guo Jiayuan , Li Guanghua , Huang He
Published: December 2022

This paper combines theoretical analysis with practical examples to examine outstanding issues in research on the inversion-based identification of dense non-aqueous phase liquids (DNAPLs) in groundwater. We first generalize the relevant geological and hydrogeological conditions to establish a conceptual model of groundwater contamination. We then use it to formulate a preliminary model of the contamination of groundwater by DNAPLs based on multi-phase flow to describe the mechanism of migration of these pollutants. Following this, a surrogate model is established by training and validating the deep convolutional neural network (DCNN) based on training samples and samples for verification. Finally, the surrogate model is embedded into an optimization model as an equality constraint and the particle swarm optimization (PSO) algorithm is used to solve it.
Percepciones sobre la dentición decidua que poseen las madres de familia de una institución educativa de Lima Metropolitana, 2021
Authors: Pizarro Jimenez Norah Iliyá , Ayala Mendívil Ronald Espíritu
Published: December 2022

Objetivo: Explorar las percepciones sobre la dentición decidua, que poseen las madres de familia de niños de 3 y 4 años de la I.E.T N° 134 “Ramiro Prialé Prialé” El Agustino, 2021. Materiales y métodos: El estudio es de enfoque cualitativo con diseño fenomelógico; la técnica empleada para la recolección de los datos fueron las entrevistas a profundidad. La muestra estuvo conformada por 11 madres de familia de la I.E.T N° 134 “Ramiro Prialé Prialé”. Previo a las entrevistas a las madres de familia se aplicó el consentimiento informado. La información obtenida fue transcrita a Word y fueron procesadas mediante el programa Atlas ti 2022, identificándose categorías, Sub-categorías y códigos. Resultados: Emergieron 5 categorías: 1) Nociones sobre los dientes de leche, 2) Percepciones sobre la salud oral actual del niño, 3) Influencia del estado de la salud oral, 4) Percepciones sobre la pérdida temprana de los dientes de leche y 5) Prevención en salud bucal infantil. A su vez emergieron Sub-categorías y códigos que evidenciaron la relaciones que hay entre ellas. Conclusiones: Las madres de familias percibían que los cuidados de los dientes de leche no debían ser tan profundos por tratarse de dientes no duraderos; priorizaban otros temas de salud que la salud oral, motivo por el cual algunas no sentían preocupación ante la pérdida prematura de los dientes de leche. La prevención de la salud bucal era asociada principalmente al adecuado cepillado, a una alimentación saludable y a una revisión odontológica desde temprana edad.
Solid-solid Phase Transitions between Crystalline Polymorphs of Organic
Materials
Authors: Rietveld Ivo B.
Published: December 2022

In this review, the analysis of solid-solid phase transitions between crystalline polymorphs of organic
molecules is discussed. Although active pharmaceutical ingredients (APIs) are the scope of the review,
whether an organic molecule has a biological activity or not does not particularly define its interactions in the
crystalline state. Therefore, other small organic molecules have been included in this analysis and in certain cases,
polymers have been discussed too. The focus of the review is on experimental analysis; however, a section
on computational and theoretical methods has been added because these methods are becoming important and
are obviously helpful in understanding for example transition mechanisms because the results can be easily visualized.
The following aspects of solid-solid phase transitions between crystalline structures are presented in this
review. The thermodynamics of phase transitions between polymorphs involving thermodynamic equilibrium
and the variables temperature and pressure closely linked to the Gibbs free energy are discussed. The two main
transition mechanisms in the organic crystalline solid, displacive and concerted, are discussed. Experimental
methods that are used to understand the mechanisms and thermodynamic equilibrium between different polymorphs
of an API are reviewed. The switching of polymorph properties is discussed, and heat storage and release
are reviewed as it is one of the main applications of solid-state phase transitions. Of interest for the control
of drug products, constraining phase transitions has been reviewed, as it may help increase the bioavailability
of an API by using metastable phases. Finally, second order phase transitions of organic materials, which appear
to be rare, are discussed. It can be concluded that although the general theory of polymorphism and phase
transitions is well understood, how it works out for a specific molecule remains difficult to predict.
Immunosuppressive Effects of Annona muricata L. Leaf Extract on
Cellular and Humoral Immune Responses in Male Wistar Rats
Authors: Jantan Ibrahim , Abdul Wahab Siti Mariam , Husain Khairana , Arshad Laiba , Haque Md. Areeful , Mohd Fauzi Norsyahida , Nafiah Mohd Azlan , Das Srijit
Published: December 2022

Background:

Annona muricata L. (Annonaceae) (AM)'s remarkable anti-inflammatory
and anti-cancer activities make it a targeted plant to be explored for its immunomodulatory properties.
Traditional practitioners have employed various components of AM to cure a variety of ailments,
including cancer, diabetes, and inflammation.

Objective:

The present study evaluated the immunosuppressive effects of 80% ethanol extract of of
AM leaves in male Wistar rats on different parameters of humoral and cellular immune responses.

Methods:

AM leaf extract (AMLE) was analyzed using UHPLC-MS/MS to profile its secondary
metabolites. AMLE was rich in polyphenols which include (epi)catechin-(epi)catechin-(epi) catechin,
caffeic acid, coumaroylquinic acid, hyperin, kaempferol, quinic acid and rutin. The rats were
administered 100, 200 and 400 mg/kg bw of the extract daily for 14 days. The effects of AMLE on
innate immune responses were determined by evaluating phagocytosis, neutrophils migration, reactive
oxygen species (ROS) release, CD11b/CD18 integrin expression, and ceruloplasmin, lysozyme
and myeloperoxidase (MPO) levels. The adaptive immune parameters were evaluated by immunizing
the rats with sheep red blood cells (sRBC) on day 0 and administered orally with AMLE for 14
days.

Results:

AMLE established significant immunosuppressive effects on the innate immune parameters
by inhibiting the neutrophil migration, ROS production, phagocytic activity and expression of
CD11b/CD18 integrin in a dose-dependent pattern. AMLE also suppressed ceruloplasmin, MPO
and lysozyme expressions in the rat plasma dose-dependently. AMLE dose-dependently inhibited T
and B lymphocytes proliferation, Th1 and Th2 cytokine production, CD4+ and CD8+ co-expression
in splenocytes, immunoglobulins (IgM and IgG) expression and the sRBC-induced swelling rate of
rat paw in delayed-type hypersensitivity (DTH).

Conclusion:

The strong inhibitory effects on the different parameters of humoral and cellular
responses indicate that AMLE has potential to be an important source of effective immunosuppressive
agents.
Chloroquinolone Carboxamide Derivatives as New Anti-HSV-1 Promising
Drugs
Authors: Cirne-Santos Claudio Cesar , Souza Mariana , de Melo Camilly Pestana Pires , Faro Letícia Villafranca , Fragel-Madeira Luciane , Giongo Viveca , Abreu Paula Alvarez , da Costa Santos Boechat Fernanda , de Oliveira Silva David , de Carvalho Tolentino Nathalia Motta , de Souza Barros Caroline , Castro Helena Carla , de Souza Marcos Costa , de Souza Maria Cecília Bastos Vieira , de Palmer Paixão Izabel Christina Nunes
Published: December 2022

Background:

Since the emergence of HSV resistant strains, new antiviral agents have emerged and still are urgently needed, especially those with alternative targets.

Objective:

In this work, we evaluated new quinolone derivatives as anti-HSV.

Methods:

For this study, cells were infected and treated with different components to evaluate the profile of HSV replication in vitro. In addition, studies were performed to determine the pharma-cokinetic toxicity and profile of the compound.

Results:

Indeed the EC50 values of these promising molecules ranged between 8 μM and 32 μM. We have also showed that all compounds inhibited the expression of ICP27 viral proteins, which gives new insights in the search for new target for antiherpetic therapy. Chlorine in positions C6 and phosphonate in position C1 have shown to be important for viral inhibition. The chloroquinolone carboxamide derivatives fulfilled “Lipinsky Rule of Five” for good oral bioavailability and showed higher intestinal absorption and blood brain barrier penetration, as well as lower toxicity profile.

Conclusion:

Although the inhibition activities of chloroquinolone carboxamide derivatives were lower than acyclovir, they showed different modes of action in comparison to the drugs currently available. These findings encourage us to continue pre-clinical studies for the development of new anti-HSV-1 agents.
Non-vesicular Lipid Transport Machinery in Trichomonas vaginalis: Novel Drug Targets against Trichomoniasis
Authors: Das Koushik , Debnath Utsab , Rahaman Seikh Batin , Upadhyay Shashi , Das Dikhita
Published: December 2022

Eukaryotic cells have separate membrane-enclosed organelles with distinct biochemical identities and specialized functions. The unique characteristics of each organelle are regulated by asymmetric distribution and intra-cellular trafficking of two important biomolecules, proteins and lipids. Non-vesicular lipid transport facilitated by lipid transfer proteins performs essential roles in intracellular lipid trafficking and homeostasis, while vesicular transport regulates protein traffick-ing. Comparative analysis of lipid transport machinery in protists could help us to understand the basis of parasitism and insight into eukaryotic evolution. Trichomonas vaginalis, a parasitic protist, greatly depends on receptor-ligand-mediated signaling pathways for cellular differentiation, nutrient uptake, secretion of virulence factors, and pathogenesis. Lipids, despite being key molecules of sig-naling cascades, have mechanisms of intracellular transport that are largely unexplored in T. vaginalis. We have identified a repertoire of seventeen potential lipid transfer protein (LTP) homo-logs in T. vaginalis based on a domain-based search on TrichDB (genome database of Trichomo-nas) coupled with bioinformatics analyses, which indicates the presence of well-organized lipid transport machinery in this parasite. We emphasized here their evolutionary uniqueness and conser-vation and discussed their potential implications for parasite biology in regard to future therapeutic targets against Trichomoniasis.
Dehydrogenation of Cyclohexanones to Phenols: A Mini Review
Authors: Du Yueying , Ren Dezhang , Huang Chenxin , Li Yang , Zhang Nahui , Huo Zhibao
Published: December 2022

Background:

Phenol and its derivatives are important intermediates in the chemical industry,
especially the pharmaceutical and electronic industries. The synthesis of phenols has attracted
the attention of scientists due to their importance. Dehydrogenation of cyclohexanones is one of the
promising aromatization strategies for phenols manufacture because the raw materials are low cost
and stable. In recent years, some efficient and green methods with the use of H2, O2 and air, alkene,
H2 and O2-free are described.

Objective:

This mini-review will summarize some recent developments relating to the dehydrogenation
of cyclohexanones to phenols, along with their interesting mechanism aspects. The challenges
and future trends of the transformation will be prospected.

Conclusion:

The synthesis of phenols from the dehydrogenation of cyclohexanones has recently attracted
much attention. Some synthetic methods have been established, and interesting mechanisms
have been proposed in some cases. Lots of catalysts were developed for the transformation to afford
the corresponding product. Although the present methods still have drawbacks and limitations, it is
supposed that many novel methods would probably be developed in the near future.
Mitochondria in Early Life
Authors: He Ling , Maheshwari Akhil
Published: December 2022

Mitochondria are highly-dynamic, membrane-bound organelles that generate most of the chemical energy needed to power the biochemical reactions in eukaryotic cells. These orga-nelles also communicate with the nucleus and other cellular structures to help maintain somatic homeostasis, allow cellular adaptation to stress, and help maintain the developmental trajectory. Mitochondria also perform numerous other functions to support metabolic, energetic, and epigenet-ic regulation in our cells. There is increasing information on various disorders caused by defects in intrinsic mitochondrial or supporting nuclear genes, on different organ systems. In this review, we have summarized the ultrastructural morphology, structural components, our current understanding of the evolution, biogenesis, dynamics, function, clinical manifestations of mitochondrial dysfunc-tion, and future possibilities. The implications of deficits in mitochondrial dynamics and signaling for embryo viability and offspring health are also explored. We present information from our own clinical and laboratory research in conjunction with information collected from an extensive search in the databases PubMed, EMBASE, and Scopus.
Health-related Quality of Life among Type 2 Diabetes Patients in Southern
Province of Saudi Arabia using WHOQOL-BREF: A Cross-section Study
Authors: Homady Areej , Albasheer Osama , Bajawi Amenah , Hamdi Shatha , Awaf Aisha , Madkhali Tahani , Sabai Abdallah , Zaino Mohammad R. , Somaili Mohammed
Published: December 2022

Background:

Quality of life has become a more important health outcome with advancements
in medical therapies and disease management, leading to better lives for people in
general, particularly those living with chronic diseases. Diabetes has a direct impact on the physical,
psychological, and social aspects of personal health. This study aimed to determine healthrelated
quality of life (HRQOL) and its predictors in patients with type 2 diabetes.

Methods:

A cross-sectional study was carried out on 420 patients with type 2 diabetes who presented
to primary healthcare centers in Samtah Town, Saudi Arabia, from March 2017 to February
2018. The HRQOL of the study participants was determined using the World Health Organization
Quality of Life-BREF. Multi-level linear regression was employed to ascertain the factors associated
with HRQOL among patients with type 2 diabetes.

Results:

Female sex was significantly associated with higher HbA1c, anxiety, depression, and
stress scores and a lower HRQL in the physical, psychological, and environmental health subscales
than males (P<0.001). All subscales of HRQOL were significantly lower in the > 50 years age
group. When compared to those with low levels of education (illiterate, primary, or elementary
school), patients with secondary and bachelor’s degrees had significantly higher HRQOL in all
subscales (P<0.001). In addition, there were significant differences in glycemic control and HRQL
with a longer duration of diabetes, the presence of one or more diabetes complications, and the
presence of comorbid hypertension (P<0.001). However, no significant differences in the Depression
Anxiety and Stress Scale (DASS) index were observed with a longer duration of diabetes and
the presence of comorbid hypertension. Patients with diabetes on combined therapy and healthy
diet and exercise showed significantly higher HRQOL on physical functioning (P<0.001).

Conclusion:

Type 2 diabetes was significantly associated with impaired health-related quality of
life and mental health among study participants. Females appeared to have worse quality of life
and mental health than males. Age, duration of diabetes, comorbid hypertension, diabetes complications,
and level of education were significantly associated with lower HRQOL and mental health
scores. Healthy diet and exercise, when combined with hypoglycemic and insulin therapy, were
found to improve HRQOL and mental health among patients with diabetes. Scales based on a
broad definition of health, such as the WHOQOL-BREF, are appropriate for use in primary care
settings and can enhance patient management and care.
Salvia aucheri Exhibits Antihypertensive Activity in Hypertensive Rats
Authors: Azzane Amine , Amssayef Ayoub , Eddouks Mohamed
Published: December 2022

Aims:

The present work aimed to assess the antihypertensive activity of Salvia aucheri.

Background:

Salvia aucheri (S. aucheri) is an aromatic and medicinal herb belonging to the Lamiaceae family. In Morocco, this plant is locally used for used to treat stomach, digestive disorders, rheumatism, and hypertension. Nevertheless, the effect of Salvia aucheri on hypertension has not yet been studied.

Objective:

The objective of this investigation was to evaluate the beneficial effect of the aqueous extract of S. aucheri leaves on arterial blood pressure, systolic blood pressure (SBP), mean blood pressure (MBP), diastolic blood pressure (DBP), and heart rate (HR) in normotensive and hypertensive rats. In addition, the effect of the aqueous extract of S. aucheri leaves on vasodilatation was assessed in isolated rat aortic rings with functional endothelium precontracted with epinephrine EP or KCl.

Methods::

The aqueous extract of the aerial parts of S. aucheri (AESA) was obtained, and its antihypertensive
ability was pharmacologically investigated in L-NAME hypertensive and normotensive
rats. The rats received AESA orally at two selected doses of 100 and 140 mg/kg for six hours
(acute experiment) and seven days (sub-chronic). Thereafter, systolic, diastolic, mean arterial
blood pressure and heart rate were evaluated. Moreover, the vasorelaxant activity of AESA was
performed in thoracic aortic ring rats. In addition, the mechanisms of action involved in the vasorelaxant
effect were studied.

Results:

The results indicated that AESA significantly reduced the systolic, diastolic, and mean arterial blood pressure in hypertensive rats over both single and repeated oral administration. However, AESA did not change the blood pressure parameters in normotensive rats. Concerning the results of vasorelaxant activity, the results showed that AESA was able to provoke potent vasorelaxant ability, which seems to be mediated through direct nitric oxide (NO) and NO-cyclic guanosine monophosphate pathways.

Conclusion:

The study elucidates the beneficial action of AESA as an antihypertensive and vasorelaxant agent.
Parents’ Experience and Healthcare Needs of having a Hospitalized Child with Burn Injury in Jordanian Hospitals: A Phenomenological Study Protocol
Authors: Al-Naimat Ibtihal Awwad , Abdel Razeq Nadin M.
Published: December 2022

Background:

A burn injury is a traumatic experience for the affected children and their parents. During the children’s burn injury treatment and hospitalization journey, parents experience many unmet needs. However, parents’ experiences and healthcare requirements during their children’s hospitalization have not been adequately addressed in the literature, especially in Jordan.

Objective:

A study is designed to gain in-depth knowledge of the parents’ experiences of children who require hospitalization for treatment of unintentional burn injuries.

Methods:

A descriptive phenomenological approach will be applied. Purposive sampling will be used to select parents from one teaching hospital and one public hospital. The researcher intends to collect data from the parents throughout their hospital experience from their child’s admission until after the child is discharged. The investigation and data gathering will continue until data saturation is reached. Data will be collected in three ways: multiple face-to-face semi-structured interviews with parents, the researcher’s field notes, and the parents’ diaries. The description of the phenomena will be performed following Colaizzi’s analysis method.

Result/Discussion:

The findings of this study will be an original contribution to the current literature in enhancing the understanding of pediatric burn victims’ parents’ experiences and healthcare needs during their child’s hospitalization. It is believed that the findings will help improve the quality of healthcare services provided to the parents of pediatric burn victims.

Conclusion:

This study protocol is shared to promote research quality and transparency and to inspire interested researchers.
Benzeneseleninic Acid Promoting the Selenofunctionalization of 2-
Naphthol Derivatives: Synthesis and Antioxidant Activity of 1-
Organoselanyl-naphthalen-2-ols
Authors: Mailahn Daniela H. , Araujo Daniela R. , Nobre Patrick C. , Fonseca Caren A. R. , Penteado Filipe , Lenardão Eder J. , Luchese Cristiane , Wilhelm Ethel A. , Perin Gelson
Published: December 2022

Background:

We report the synthesis and antioxidant evaluation of 1-organoselanyl-naphthalen-2-ols. The title compounds were selectively prepared through the selenofunctionalization of 2-naphthol derivatives using benzeneseleninic acids as a selenium source.

Objective:

We aimed at synthesizing 1-organoselanyl-naphthalen-2-ol by functionalizing 2-naphthol with arylseleninic acids using glycerol as the solvent and further evaluating the pharmacological activity.

Methods:

The products were synthesized at 70 °C using glycerol as a solvent in an oil bath. Reactive species (RS) tests, DPPH radical scavenging activity assay, and ABTS+ radical scavenging activity assay were performed. A statistical analysis of the data was performed.

Results and Discussion:

A total of fifteen 1-organoselanyl-naphthalen-2-ols were selectively obtained in yields of 58-95% in 0.25-48 h of reaction. Additionally, all the synthesized seleno-derivatives exhibited antioxidant activity, as revealed by their ability to scavenge DPPH and ABTS+ radicals and reduce the reactive species (RS) levels.

Conclusion:

The synthesis of 1-arylselanyl-naphthalen-2-ols was developed under mild reaction conditions using benzeneseleninic acid derivatives in reactions with 2-naphthol. All synthesized 2-naphthol derivatives exhibited antioxidant activity, as revealed by their DPPH and ABTS+ radical scavenging activity and reduced RS levels.
Digitalization in early childhood education in Vietnam
Authors: Anh Truong Ngoc , Ha Nguyen Thi
Published: December 2022

Digital transformation is the process of transforming interactions between actors on a traditional platform to interactions on a digital platform. This is the revolution that takes digitization or data as the foundation for development. This process is continuous and never stops. Digital transformation is a systematic process, so when all political, economic and social fields undergo digital transformation such as e-government, digital economy, digital businesses, digital banking, population, digital health, digital tourism...  education is also in this inevitable trend. The article points out that digital transformation of education and training is a core part of taking advantage of the impact of the global industrial revolution 4.0. and how technology is transforming early childhood education. Why is technology important in early childhood education?
PENGARUH PEMBERIAN LIMBAH CAIR TAHU TERHADAP JUMLAH SEL OSTEOKLAS TULANG ALVEOLAR TIKUS MODEL PERIODONTITIS
Authors: Rachmawati Dini , Anwar Saiful
Published: December 2022

Latar Belakang: Periodontitis adalah keradangan Jaringan pendukung gigi yang disebabkan oleh bakteri anaerob yang mengakibatkan kerusakan ligamen periodontal dan tulang alveolar. Obat antiinflamasi digunakan untuk penyakit periodontal yaitu golongan non steroid. Adanya efek samping yang ditimbulkan obat antiinflamasi maka perlu alternatif yang lebih aman seperti limbah cair tahu. Limbah industri pembuatan tahu lebih banyak berupa cairan yang masih mengandung isoflavon sehingga dapat dimanfaatkan dalam menjaga kesehatan jaringan periodontal. Tujuan: Untuk mengetahui pengaruh pemberian limbah cair tahu terhadap jumlah sel osteoklas pada jaringan periodontal tikus model periodontitis. Metode: Penelitian ini menggunakan tikus wistar dengan 5 kelompok yaitu: K-(tanpa perlakuan), K+(perlakuan bakteri Pg 0,03ml 3 hari sekali), KE-1(perlakuan bakteri Pg 0,03ml 3 hari sekali+limbah cair tahu 6ml/KgBB), KE-2(perlakuan bakteri Pg 0,03ml 3 hari sekali+limbah cair tahu 12ml/KgBB), dan KE-3(perlakuan bakteri Pg 0,03ml 3 hari sekali + limbah cair tahu 18ml/KgBB) dan setelah 28 hari dilakukan pengambilan tulang alveolar untuk dibuat preparat HE. Pengamatan sel osteoklas dengan miskroskop cahaya dengan perbesaran 400x dan dengan 5 lapang pandang. Hasil: Uji One way annova dan uji tukey HSD menunjukan adanya pengaruh pemberian limbah cair tahu terhadap jumlah sel osteoklas (p<0,05). Pada uji korelasi pearson menunjukan adanya hubungan yang berbanding terbalik antara dosis yang diberikan dengan jumlah sel osteoklas (p<0,05). Kesimpulan: Pemberian limbah cair tahu berbagai dosis memiliki hubungan yang signifikan terhadap jumlah sel osteoklas pada tulang alveolar tikus wistar dan dosis 18ml/KgBB memiliki kemampuan yang paling efektif untuk menekan jumlah sel osteoklas. Kata Kunci : Periodontitis, Anti Inflamasi, Isoflavon, Limbah Cair Tahu.
INSTRUMEN PENGUKURAN LITERASI KESEHATAN ORAL
Authors: Vidjajanti Laksmi , Ayu Maharani Diah , Novrinda Herry
Published: December 2022

Latar belakang: Pengukuran literasi kesehatan individu dimaksudkan untuk mengevaluasi potensi resiko terhadap kesehatan umum maupun kesehatan oral. Tujuan : Tujuan dari penelitian ini adalah untuk mengetahui validitas dan reliabilitas berbagai instrumen untuk mengukur Literasi Kesehatan Oral yang ada saat ini.Metode: yang digunakan dalam penulisan artikel ini adalah Narrative review, yaitu suatu penelusuran literatur yang diterbitkan dalam 10 tahun terakhir yang menggunakan berbagai data base yang ada Pubmed, Springer, Proquest, Science Direct, Google Scholar, 24 literatur digunakan dalam penelitian ini Hasil: Instrumen yang umum digunakan adalah: Rapid Estimate of Adult Literacy in Dentistry-30 (REALD-30); Rapid Estimate of Adult Literacy in Dentistry-99 (REALD99); Test of Functional Health Literacy in Dentistry (ToFHLiD); dan Oral Health Literacy Instrument (OHLI), CMOK, Health Literacy in Dentistry (HeLD) dengan berbagai struktur serta menilai kemampuan dalam hal literasi. Kesimpulan: Berbagai instrumen pengukuran Literasi Kesehatan Oral yang telah dikembangkan, digunakan diberbagai negara dengan proses cross cultural adaptation dan digunakan pada beragam populasi dan berbagai kelompok usia, menunjukkan instrumen yang valid dan reliabel. katakunci: kesehatan mulut; literasi kesehatan; adaptasi lintas budaya, reliabilitas, validitas
Aprendizagem Situada, Práxis e Saberes Sobre Invasões Biológicas de Catadores do Coral-Sol no Litoral Brasileiro
Authors: Vitame Kauano Rafael , Fernandes Bizerra Alessandra
Published: December 2022

A partir das proposições da aprendizagem situada e dos diálogos entre ciência e a comunidade local da Vila do Abraão — Rio de Janeiro, Brasil, foi investigada a conceituação do manejo de invasores biológicos enquanto prática sociocientífica que amplifica os processos de aprendizagem sobre questões que envolvem esta temática. O materialismo histórico-dialético foi utilizado como perspectiva teórico-metodológica. Ao considerar a aprendizagem por meio da prática social, buscamos as contribuições da filosofia da práxis e Paulo Freire. Assim, o conceito de invasões biológicas e suas significações foram construídos pelos participantes do manejo. As contribuições marxistas da práxis e de Paulo Freire foram necessárias para o processo de síntese teórica deste trabalho, que aponta as potencialidades da prática de catação (manejo) como local de intercâmbio das relações entre ciência e sociedade através da práxis, conscientização e ação sobre a realidade.
Entrevista com Eloy Rodrigues: “Não Haverá Ciência Aberta, Se Não For Abandonado o Uso Excessivo e Errado das Métricas”
Authors: Costa e Silva Elsa
Published: December 2022

Eloy Rodrigues é membro do Grupo de Especialistas em Ciência 2.0/Ciência Aberta da Associação das Universidades Europeias, em representação do Conselho de Reitores das Universidades Portuguesas. Profundo conhecedor das questões da ciência aberta e um dos principais atores deste movimento em Portugal, é diretor dos Serviços de Documentação e Bibliotecas da Universidade do Minho (UMinho). É um dos principais advogados da adesão a práticas de ciência aberta e da inclusão do acesso aberto nas políticas institucionais. Coordenou a participação da UMinho em mais de uma dezena de projetos (como o OpenAIRE, https://www.openaire.eu/, e o FOSTER, https://www.fosteropenscience.eu/) financiados pela União Europeia e relacionados com os repositórios e a ciência aberta, sendo uma figura ímpar na concretização do acesso aberto a partir dos repositórios institucionais. Foi presidente do Conselho Executivo da Confederação de Repositórios de Acesso Aberto (https://www.coar-repositories.org/), de 2015 a 2021, e coordena, desde 2008, a equipa da UMinho que desenvolve o projeto Repositórios Científicos de Acesso Aberto de Portugal (www.rcaap.pt).