bluuebunny/crossref_metadata_2025 huggingface dataset:
Do blind people share the tall-man stereotype?
Authors: Stefanczyk Michal Mikolaj , Wernecka Natalia , Sorokowski Piotr , Sorokowska Agnieszka
Published: March 2019

The stereotype of a tall man has been reported in numerous studies. High stature is commonly associated with advantages such as leadership skills, wealth, intelligence or social status, and actual differences between the short and the tall men were indeed found for these traits, mainly in favor of the tall men. It is not certain, however, whether the height-related effects are biologically determined or if they result from socially-driven mechanisms. In this study we wanted to explore whether congenitally blind individuals, who are unable to perceive other people’s stature through the most salient, visual channel, share the positive, height-related stereotype. Thirty-four congenitally blind and forty-three sighted men and women rated four positive characteristics of a tall or a short man. It was found that none of the traits assigned to the tall man by the sighted people was assigned to this person by the blind individuals. In the congenitally blind group, no differences between the assessments of the tall and the short man were revealed. We discuss our findings in the context of social perception and stereotypes research.
Editorial
Authors: Barrett Steve
Published: March 2019

French companies and research organisations are active in all parts of the fuel cell and hydrogen energy sectors, with major roles in national, European and international initiatives.
Ajusa Hydrogen Technologies develops novel bipolar plates with optimised water management for fuel cell stack
Authors: Iranzo Alfredo , Gregorio José Manuel
Published: March 2019

Spanish company Ajusa Hydrogen Technologies and the Thermal Engineering Group at the University of Sevilla are completing a research project named AGUAPEM (Research on water management in PEM Fuel Cells and optimisation of their power systems), funded by the Spanish Ministry of Science, Innovation and Universities.
Health and Health Seeking in Mosul During ISIS Control and Liberation: Results From a 40-Cluster Household Survey
Authors: Lafta Riyadh , Cetorelli Valeria , Burnham Gilbert
Published: March 2019

Objectives

ISIS seized Mosul in June 2014. This survey was conducted to assess health status, health needs, and health-seeking behavior during ISIS control and the subsequent Iraqi military campaign.

Methods

Forty clusters were chosen: 25 from east Mosul and 15 from west Mosul. In each, 30 households were interviewed, representing 7559 persons. The start house for each cluster was selected using satellite maps. The survey in east Mosul was conducted from March 13–31, 2017, and in west Mosul from July 18–31, 2017.

Results

In the preceding 2 weeks, 265 (5.4%) adults reported being ill. Some 67 (25.3%) complaints were for emotional or behavioral issues, and 59 (22.3%) for noncommunicable diseases. There were 349 (13.2%) children under age 15 reportedly ill during this time. Diarrhea, respiratory complaints, and emotional and behavioral problems were most common. Care seeking among both children and adults was low, especially in west Mosul. During ISIS occupation, 640 (39.0%) women of childbearing age reported deliveries. Of these, 431 (67.3%) had received some antenatal care, and 582 (90.9%) delivered in a hospital. Complications were reported by 417 (65.2%).

Conclusions

Communicable and noncommunicable diseases were reported for both children and adults, with a high prevalence of emotional and behavioral problems, particularly in west Mosul. Care-seeking was low, treatment compliance for noncommunicable diseases was poor, and treatment options for patients were limited. (Disaster Med Public Health Preparedness. 2019;13:758–766)
Flow of a thin liquid-metal film in a toroidal magnetic field
Authors: Lunz D. , Howell P. D.
Published: March 2019

We investigate the gravity-driven flow of a thin film of liquid metal on a conducting conical substrate in the presence of a strong toroidal magnetic field (transverse to the flow and parallel to the substrate). We solve the leading-order governing equations in a physically relevant asymptotic limit to find the free-surface profile. We find that the leading-order fluid flow rate is a non-monotonic bounded function of the film height, and this can lead to singularities in the free-surface profile. We perform a detailed stability analysis and identify values of the relevant geometric, hydrodynamic and magnetic parameters such that the flow is stable.
Relaminarising pipe flow by wall movement
Authors: Scarselli D. , Kühnen J. , Hof B.
Published: March 2019

Following the recent observation that turbulent pipe flow can be relaminarised by a relatively simple modification of the mean velocity profile, we here carry out a quantitative experimental investigation of this phenomenon. Our study confirms that a flat velocity profile leads to a collapse of turbulence and in order to achieve the blunted profile shape, we employ a moving pipe segment that is briefly and rapidly shifted in the streamwise direction. The relaminarisation threshold and the minimum shift length and speeds are determined as a function of Reynolds number. Although turbulence is still active after the acceleration phase, the modulated profile possesses a severely decreased lift-up potential as measured by transient growth. As shown, this results in an exponential decay of fluctuations and the flow relaminarises. While this method can be easily applied at low to moderate flow speeds, the minimum streamwise length over which the acceleration needs to act increases linearly with the Reynolds number.
Response of the flow dynamics of Bowdoin Glacier, northwestern Greenland, to basal lubrication and tidal forcing
Authors: SEDDIK HAKIME , GREVE RALF , SAKAKIBARA DAIKI , TSUTAKI SHUN , MINOWA MASAHIRO , SUGIYAMA SHIN
Published: March 2019

We use the full-Stokes model Elmer/Ice to investigate the present dynamics of Bowdoin Glacier, a marine-terminating outlet glacier in northwestern Greenland. Short-term speed variations of the glacier were observed, correlating with air temperature and precipitation, and with the semi-diurnal ocean tides. We use a control inverse method to determine the distribution of basal friction. This reveals that most of the glacier area is characterized by near-plug-flow conditions, while some sticky spots are also identified. We then conduct experiments to test the sensitivity of the glacier flow to basal lubrication and tidal forcing at the calving front. Reduction of the basal drag by 10–40% produces speed-ups that agree approximately with the observed range of speed-ups that result from warm weather and precipitation events. In agreement with the observations, tidal forcing and surface speed near the calving front are found to be in anti-phase (high tide corresponds to low speed, and vice versa). However, the amplitude of the semi-diurnal variability is underpredicted by a factor ~ 3, which is likely related to either inaccuracies in the surface and bedrock topographies or mechanical weakening due to crevassing.
DUAL DIFFERENTIATION SPACES
Authors: MOORS WARREN B. , TAN NEŞET ÖZKAN
Published: March 2019

We show that if
$(X,\Vert \cdot \Vert )$
is a Banach space that admits an equivalent locally uniformly rotund norm and the set of all norm-attaining functionals is residual then the dual norm
$\Vert \cdot \Vert ^{\ast }$
on
$X^{\ast }$
is Fréchet at the points of a dense subset of
$X^{\ast }$
. This answers the main open problem in a paper by Guirao, Montesinos and Zizler [‘Remarks on the set of norm-attaining functionals and differentiability’, Studia Math.
241 (2018), 71–86].
A NOTE ON MATRIX APPROXIMATION IN THE THEORY OF MULTIPLICATIVE DIOPHANTINE APPROXIMATION
Authors: ZHANG YUAN
Published: March 2019

We prove the Hausdorff measure version of the matrix form of Gallagher’s theorem in the inhomogeneous setting, thereby proving a conjecture posed by Hussain and Simmons [‘The Hausdorff measure version of Gallagher’s theorem—closing the gap and beyond’, J. Number Theory186 (2018), 211–225].
THE 1860 JAPANESE EMBASSY AND THE ANTEBELLUM AFRICAN AMERICAN PRESS
Authors: DOAN NATALIA
Published: March 2019

The 1860 Japanese embassy inspired within the antebellum African American press an imagined solidarity that subverted American state hierarchies of ‘civilization’ and race. The bodies of the Japanese ambassadors, physically incongruous with American understandings of non-white masculinity, became a centre of cultural contention upon their presence as sophisticated and powerful men on American soil. The African American and abolitionist press, reimagining Japan and the Japanese, reframed racial prejudice as an experience in solidarity, to prove further the equality of all men, and assert African American membership to the worlds of civility and ‘civilization’. The acceptance of the Japanese gave African Americans a new lens through which to present their quest for racial equality and recognition as citizens of American ‘civilization’. This imagined transnational solidarity reveals Japan's influence in the United States as African American publications developed an imagined racial solidarity with Japanese agents of ‘civilization’ long before initiatives of ‘civilization and enlightenment’ appeared on Japan's diplomatic agenda. Examining the writings of non-state actors traditionally excluded from early historical narratives of US–Japan diplomacy reveals an imagined transnational solidarity occurring within and because of an oppressive racial hierarchy, as well as a Japanese influence on antebellum African American intellectual history.
Adjoint approach to calculating shape gradients for three-dimensional magnetic confinement equilibria
Authors: Antonsen Thomas , Paul Elizabeth J. , Landreman Matt
Published: March 2019

The shape gradient quantifies the change in some figure of merit resulting from differential perturbations to a shape. Shape gradients can be applied to gradient-based optimization, sensitivity analysis and tolerance calculation. An efficient method for computing the shape gradient for toroidal three-dimensional magnetohydrodynamic (MHD) equilibria is presented. The method is based on the self-adjoint property of the equations for driven perturbations of MHD equilibria and is similar to the Onsager symmetry of transport coefficients. Two versions of the shape gradient are considered. One describes the change in a figure of merit due to an arbitrary displacement of the outer flux surface; the other describes the change in the figure of merit due to the displacement of a coil. The method is implemented for several example figures of merit and compared with direct calculation of the shape gradient. In these examples the adjoint method reduces the number of equilibrium computations by factors of$O(N)$, where$N$is the number of parameters used to describe the outer flux surface or coil shapes.
Several parameters that influence body size in the sea anemone Actinia equina in rock pools on the Yorkshire coast
Authors: Carling Bryony , Gentle Louise K. , Ray Nicholas D.
Published: March 2019

Despite being classed as an asocial species, aggregations of sea anemones can be common in abundant species. UK populations of the geographically common aggressive intertidal sea anemone Actinia equina, form clustered aggregations notwithstanding a violent nature towards neighbours and relatives. Smaller in body size, and more abundant than those found in warmer climates, little research has been undertaken to discover what factors affect body size. This study investigates whether aggregation, distance to neighbour, submergence at low tide or pH in rock pools affect body size of A. equina in their natural habitat. Populations were investigated at five sites on the Yorkshire coast during August and September 2016. A total of 562 anemones were recorded revealing that solitary anemones were significantly larger than those found in clustered aggregations. In addition, anemones found submerged in rock pools at low tide were significantly larger than those found on emergent rock, and smaller anemones were found in significantly higher pH conditions (8.5+) than larger anemones. Anemones submerged at low tide are constantly able to feed and not subject to harsh conditions such as wind exposure and temperature, hence they can achieve larger sizes. Consequently, the size of the anemones may reflect a trade-off between the benefits of aggregating in exposed environments and the costs of competition for a reduced food resource.
‘Performed Conviviality’: Space, bordering, and silence in the city
Authors: CHAMBERS THOMAS
Published: March 2019

Through ethnographic material gathered in the Muslim woodworkingmohallas(neighbourhoods) of a North Indian city, this article attends to ‘performed’ elements of everyday convivial interactions. It builds on work that situates conviviality as a normative project aimed at understanding and fostering interaction within urban space which bridges forms of difference. Through descriptive accounts, the article illustrates how convivial exchanges can embody degrees of instrumentality and conceal relations of power and marginalization that act to silence outrage or contestation. This ‘performed conviviality’ is dealt with in a broader context of ‘scale’ to consider how marginalization and connectedness—the marginal hub—intersect in even the most mundane moments of convivial exchange. By tracing processes of marginalization, boundary making, and bordering within the local, city-wide, state, and international contexts, the article follows the production of a marginalized or ‘border’ subjectivity through to the individual level. The subjectivities produced in this context act to enforce degrees of self-imposed silence among those subjected to processes of marginalization. In addition—and again attending to scale through an acknowledgement of the connected nature of themohallas—the article also considers the role of conviviality in global chains of supply through the creation and maintenance of bonds and obligations that facilitate production in the city's wood industry.
Danger and Difference: Teatime at the northeast India-Bangladesh border
Authors: SUR MALINI
Published: March 2019

This article asks what can be learned about affinity and alterity by considering how villagers and state troops collectively live in remote and often dangerous borders. Situating this question along South Asia's longest international boundary—the India-Bangladesh border—I query the political possibilities of conviviality that bear upon altering notions of reciprocity, exchange, and trust, and which have not attracted the attention of either urban or border scholars. I argue that reciprocal webs of exchange brought Garo matrilineal kinship and Christian religiosity into relations with seemingly impersonal worlds of state control and border rule. The exchange of valued domestic objects, and the broader set of political and gendered affinities that surrounded these, are evidence of the border's changing role and temporality in mitigating difference and danger. Although these relations are embedded in the history of border-making in the Garo Hills, recent national security measures and border infrastructures have disrupted prior exchanges. These have disembedded the troops from their immediate rural environment in attempts to contain trans-border relationships.
Producing a Distant Centre: The role of wilderness in the post-Mao Tibetan Buddhist revival
Authors: CHO YASMIN
Published: March 2019

This article addresses how wilderness—through its qualities of remoteness and wildness—plays an essential role in the production of a vital religious centre in Tibet. By drawing on in-depth ethnographic observations in Yachen Gar, a mega-sized Buddhist encampment in the nomadic grasslands of China's northwestern Sichuan province, I examine the spatial and material features of the encampment, how various agents utilize these features to produce specific relations with it, and how, in this process, Yachen has become a centre of the Buddhist revival in Kham Tibet. I will present three ethnographic accounts—which focus on a Tibetan nun from the Tibet Autonomous Region (TAR), Chinese pilgrims, and reactions to the spread of electricity in Yachen—to address the ways in which Yachen is emplaced within the spatial and material tensions implemented and imagined by different participants. These accounts ultimately show how materiality plays a crucial role in forging the various contesting relations, actions, and meanings that constitute a social space.
Changes in the dynamic network structure of PTSD symptoms pre-to-post combat
Authors: Segal Adva , Wald Ilan , Lubin Gad , Fruchter Eyal , Ginat Keren , Ben Yehuda Ariel , Pine Daniel S. , Bar-Haim Yair
Published: March 2019

Background

Combat exposure is associated with elevated risk for post-traumatic stress disorder (PTSD). Despite considerable research on PTSD symptom clustering, it remains unknown how symptoms of PTSD re-organize following combat. Network analysis provides a powerful tool to examine such changes.

Methods

A network analysis approach was taken to examine how symptom networks change from pre- to post-combat using longitudinal prospective data from a cohort of infantry male soldiers (Mage = 18.8 years). PTSD symptoms measured using the PTSD Checklist (PCL) were assessed after 6 months of combat training but before deployment and again after 6 months of combat (Ns = 910 and 725 at pre-deployment and post-combat, respectively)

Results

Stronger connectivity between PTSD symptoms was observed post-combat relative to pre-deployment (global strength values of the networks were 7.54 pre v. 7.92 post; S = .38, p < 0.05). Both the re-experiencing symptoms cluster (1.92 v. 2.12; S = .20, p < 0.03) and the avoidance symptoms cluster (2.61 v. 2.96; S = .35, p < 0.005) became more strongly inter-correlated post-combat. Centrality estimation analyses revealed that psychological reaction to triggers was central and linked the intrusion and avoidance sub-clusters at post-combat. The strength of associations between the arousal and reactivity symptoms cluster remained stable over time (1.85 v. 1.83; S = .02, p = .92).

Conclusions

Following combat, PTSD symptoms and particularly the re-experiencing and avoidance clusters become more strongly inter-correlated, indicating high centrality of trigger-reactivity symptoms.
Photovoice method with older persons: a review
Authors: Mysyuk Yuliya , Huisman Martijn
Published: March 2019

For a long time researchers have used photography for different purposes, in different ways and with different focus. Photovoice is a qualitative visual research method that refers to photographs taken by the participants themselves. It has been used with different age groups and populations. The use of photovoice in older populations requires its own study of approaches, techniques and challenges. In this article, we review existing studies using photovoice with older participants specifically, to consider its potential as a qualitative research method in the field of gerontology. We discuss advantages and limitations of the method in gerontological research and provide guidelines for future studies. Our results show that photovoice has been used to study a wide range of topics in older people, from health issues and the impact of environment on health and wellbeing, to leisure experiences of groups living with HIV/AIDS. Using photovoice helps researchers to capture live experiences and perceptions of older persons and conduct engaging, involving and empowering research facilitating interaction, reflection and connection of participants. However, conducting photovoice studies can be practically challenging, such as when addressing special needs of the participants, or ethical and other feasibility issues. To conclude, photovoice has great potential for being used in gerontological research, it can be altered to fit specific goals, divergent issues studied and different research contexts.
Methods Assessing Sociocultural Aspects of Health Technologies: Results of a Literature Review
Authors: Stich Anne Kathrin , Mozygemba Kati , Lysdahl Kristin Bakke , Pfadenhauer Lisa Maria , Hofmann Bjørn , van der Wilt Gert-Jan , Gerhardus Ansgar
Published: March 2019

Objectives

Social and cultural aspects are rarely assessed in health technology assessments (HTA), despite being part of most HTA definitions. One hypothesis for the reason why they are hardly considered in HTA is that we lack relevant assessment methods. Accordingly, this review aims at providing an overview of methodological approaches to address social and cultural aspects related to health technologies in HTA.

Methods

We conducted a comprehensive literature search by searching fourteen databases and a hand-search of two pertinent journals. Additionally, we sent a query to all member agencies of the International Network of Agencies for Health Technology Assessment (INAHTA) asking them for methods they use to assess social and cultural aspects.

Results

A total of 125 publications met our inclusion criteria. We grouped the methodological approaches into checklists for experts, literature reviews, stakeholder participatory approaches, primary data collection methods, and combinations of methodological approaches.

Conclusions

There is a wide variety of methods available for assessing social and cultural aspects of health technologies, some of which have been applied in HTA. The presented overview of the different approaches and their merits can facilitate the assessment of these aspects, and improve the knowledge regarding (potential) success and failure of the implementation of a health technology.
Gut rest strategy and trophic feeding in the acute phase of critical illness with acute gastrointestinal injury
Authors: Zhang Dong , Li Hongxiang , Li Yuting , Qu Lai
Published: March 2019

Critically ill patients frequently suffer from gastrointestinal dysfunction as the intestine is a vulnerable organ. In critically ill patients who require nutritional support, the current guidelines recommend the use of enteral nutrition within 24–48 h and advancing towards optimal nutritional goals over the next 48–72 h; however, this may be contraindicated in patients with acute gastrointestinal injury because overuse of the gut in the acute phase of critical illness may have an adverse effect on the prognosis. We propose that trophic feeding after 72 h, as a partial gut rest strategy, should be provided to critically ill patients during the acute phase of illness as an organ-protective strategy, especially for those with acute gastrointestinal injury.
Parents’ adverse childhood experiences and parent–child emotional availability in an American Indian community: Relations with young children's social–emotional development
Authors: Wurster Hannah E. , Sarche Michelle , Trucksess Caitlin , Morse Brad , Biringen Zeynep
Published: March 2019

This study examined relations among parent adverse childhood experiences (ACEs), parent mental distress, child social–emotional functioning, and parent emotional availability (EA) among parents and children served by an Early Head Start program in an American Indian community. The majority of parents and children in the study were American Indian/Alaska Native. American Indian/Alaska Native communities experience relatively high rates of trauma, socioeconomic disparities, and mental health challenges. In this context, young children may be especially vulnerable to early life stress. Further, a strong body of literature demonstrates the long-term effects of ACEs on individuals’ mental health, as well as their child's social–emotional functioning. In this study we examined a model to test the relation of parent ACEs to children's social–emotional functioning, with an indirect effect via a latent “mental distress” variable consisting of parent depression, anxiety, and parenting-related distress. Results supported this model, suggesting that parent ACEs related to children's social–emotional problems by way of parent mental distress. However, when a categorical measure of parent EA was added as a moderator, the model only remained significant in the low EA parent group. These results provided evidence for a “buffering” effect of high parent EA on the relation between parent ACEs, parent mental distress, and children's social–emotional problems.
Decrease in Seismic Velocity Observed Prior to the 2018 Eruption of Kīlauea Volcano With Ambient Seismic Noise Interferometry
Authors: Olivier G. , Brenguier F. , Carey R. , Okubo P. , Donaldson C.
Published: March 2019

The 2018 Kīlauea eruption was a complex event that included deformation and eruption at the summit and along the East Rift Zone. We use ambient seismic noise interferometry to measure time‐lapse changes in seismic velocity of the volcanic edifice prior to the lower East Rift Zone eruption. Our results show that seismic velocities increase in relation to gradual inflation of the edifice between 1 March and 20 April. In the 10 days prior to the 3rd of May eruption onset, a rapid seismic velocity decrease occurs even though the summit is still inflating. We confirm that intereruptive velocity change is correlated with surface deformation, while the velocity decrease prior to eruption is likely due to accumulating damage induced by the pressure exerted by the magma reservoir on the edifice. The accumulating damage and subsequent decrease in bulk edifice strength may have facilitated increased transport of magma from the summit reservoir to the Middle East Rift Zone.
Tetrahydrofuran Hydrate in Clayey Sediments—Laboratory Formation, Morphology, and Wave Characterization
Authors: Liu Zhichao , Kim Jongchan , Lei Liang , Ning Fulong , Dai Sheng
Published: March 2019

Fine‐grained sediments host more than 90% of gas hydrates on Earth. However, the fundamental properties of hydrate‐bearing silty and clayey sediments are much less understood than those of hydrate‐bearing sands, mainly due to the experimental challenges in synthesizing gas hydrate in fine‐grained sediments in the laboratory as the way they form in nature. This study forms tetrahydrofuran (THF) hydrate in kaolinite, visualizes the hydrate distribution and morphology using X‐ray computed tomography, and uses P and S waves to characterize the formed hydrate‐bearing clayey sediments. The results show that THF hydrate formed in clay is innately segregated and heterogeneous, no longer as a pore constituent as in sandy sediments. Hydrate nucleation, growth, and distribution in clays are dominated by the thermal condition and constrained by water activity and mass transport, which can result in low stoichiometric‐solution‐to‐hydrate conversion ratios of approximately 0.4–0.7. Thus, the estimation of hydrate volume in clays based on the mass of stoichiometric solution can be erroneous. The heterogeneity in hydrate‐bearing clays imposes challenges in wave velocity based characterization. The bulk elastic properties of hydrate‐bearing clays can be well predicted using the self‐consistent model. Specimens with higher hydrate volume fraction VFh show higher wave attenuations Q−1, highlighting the dominant role of THF hydrate in the wave attenuation of hydrate‐bearing clays. The results suggest that Qp−1 = 0.08 + 0.4VFh = 2Qs−1, which underlines the potential of using wave attenuation based methods to quantify the hydrate volume fraction in clayey sediments.
Assessing the Iterative Finite Difference Mass Balance and 4D‐Var Methods to Derive Ammonia Emissions Over North America Using Synthetic Observations
Authors: Li Chi , Martin Randall V. , Shephard Mark W. , Cady‐Pereira Karen , Cooper Matthew J. , Kaiser Jennifer , Lee Colin J. , Zhang Lin , Henze Daven K.
Published: March 2019

We evaluate two inverse modeling methods by conducting inversion experiments using the GEOS‐Chem chemical transport model and its adjoint. We simulate synthetic NH3 column density as observed by the Cross‐track Infrared Sounder over North America to test the ability of the iterative finite difference mass balance (IFDMB) and the four‐dimensional variational assimilation (4D‐Var) methods to recover known NH3 emissions. Comparing to the more rigorous 4D‐Var method, the IFDMB approach requires 3–4 times lower computational cost and yields similar or smaller errors (12–17% vs 17–26%) in the top‐down inventories at 2° × 2.5° resolution. These errors in IFDMB‐derived emission estimates are amplified (53–62%) if compared to the assumed true emissions at 0.25° × 0.3125° resolution. When directly conducting inversions at 0.25° × 0.3125°, the IFDMB consistently exhibits larger errors (44–69% vs 30–45%) than the 4D‐Var approach. Analysis of simulated differences in NH3 columns and in NH3 emissions suggests stronger misalignments at the finer resolution, since the local column is more strongly influenced by spatial smearing from neighboring grids. Adjoint calculations indicate that the number of adjacent grids needed to account for most (>65%) of the emission contributions to the local columnar NH3 abundance over an NH3 source site increases from ~1 at 2° × 2.5° to ~10 at 0.25° × 0.3125°, leading to increased errors especially in IFDMB. Applying inversion results at 2° × 2.5° to update the a priori emissions at 0.25° × 0.3125° could improve the accuracy of IFDMB inversions and reduce the computational cost of 4D‐Var.
Western Mediterranean Sea Paleothermometry Over the Last Glacial Cycle Based on the Novel RI‐OH Index
Authors: Davtian Nina , Ménot Guillemette , Fagault Yoann , Bard Edouard
Published: March 2019

RI‐OH (ring index of hydroxylated tetraethers) has recently been proposed to reconstruct paleotemperatures in middle‐ to low‐latitude marginal seas. However, RI‐OH has barely been tested in marginal seas under substantial terrigenous inputs. Here we analyze tetraether lipids in two adjacent marine cores from the Gulf of Lions. We then test for the first time the RI‐OH paleothermometer from 160 to 9 ka BP in the western Mediterranean Sea. While terrigenous inputs prevent TEX86 (TetraEther indeX of tetraethers consisting of 86 carbon atoms) from behaving as a paleothermometer, RI‐OH is generally consistent with other paleothermometric proxies. RI‐OH also responds systematically and coherently to glacial‐interglacial transitions as well as to abrupt climatic events. The average difference between RI‐OH temperatures and November–May UK′37 (C37 ketone unsaturation ratio) temperatures is −2.0 °C with a standard error of 0.4 °C based on 249 RI‐OH‐UK′37 comparisons. This systematic difference suggests that hydroxylated tetraethers and alkenones record different temperatures, for instance, winter and/or subsurface temperatures for RI‐OH. Another source of bias could be linked to the available RI‐OH‐temperature calibration, which clearly needs more work at the global and regional scales, notably for semienclosed basins such as the Mediterranean Sea. Nevertheless, our RI‐OH‐based interglacial‐glacial anomalies are of 10 °C, a value within the high end of anomalies from previously published temperature records in the western Mediterranean Sea (from 3 to 13 °C). The RI‐OH‐based temperature anomalies also confirm the regional differences and seasonal contrasts in interglacial‐glacial anomalies produced by models.
Calcareous Nannofossil Response to Climate Variability During the Middle Pleistocene Transition in the Northwest Pacific Ocean (Ocean Drilling Program Leg 198 Site 1209)
Authors: Lupi C. , Bordiga M. , Sacchi R. , Ferretti P. , Cobianchi M.
Published: March 2019

The Middle Pleistocene Transition represents an important reorganization of climate that switched from a 41‐kyr periodicity to a quasiperiodic 100‐kyr cycle. Here, we have investigated this time interval using calcareous nannofossils from a midlatitude well‐preserved sedimentary record from the Ocean Drilling Program Site 1209 in the North West Pacific Ocean. We studied samples from 1.45 to 0.45 Ma, looking for significant changes in the nannofossil assemblages. Micropaleontological data were processed using an information theoretic model comparison that deconvolutes variations in nannofossil assemblages using different predictors. The major findings are that calcareous nannofossils permit the detection of discrete events during the Middle Pleistocene Transition. They display three different associations belonging, respectively, to the 41‐kyr world, the transition, and the 100‐kyr world. The statistical approach demonstrated that nannofossils responded abruptly at the boundaries of the transition developing in two rapid steps superimposed on a more gradual process. Moreover, a strong decrease in the genus Reticulofenestra and the beginning of the Gephyrocapsa caribbeanica acme permitted us to pinpoint climate events within the Middle Pleistocene Transition. Finally, through the nannofossil paleoecology, we documented an anomalous long‐term warming trend that could be related to an intensification of the Walker circulation and the stabilization of long‐term conditions like La Niña at the midlatitudes of the NW Pacific during the Middle Pleistocene Transition.
Snow Drought Risk and Susceptibility in the Western United States and Southwestern Canada
Authors: Dierauer Jennifer R. , Allen Diana M. , Whitfield Paul H.
Published: March 2019

In western North America (WNA), mountain snowpack supplies much of the water used for irrigation, municipal, and industrial uses. Thus, snow droughts (a lack of snow accumulation in winter) can have drastic ecological and socioeconomic impacts. In this study, the historical (1951–2013) frequency, severity, and risk (frequency × severity) of dry, warm, and warm and dry snow droughts are quantified at the grid‐cell and ecoregion scale for snow‐dominated regions in the western United States and southwestern Canada (sWNA). Based on multiple linear regression analysis, relationships between mean winter temperature, snow drought risk, and snow water equivalent sensitivity are explored. Piecewise linear regression is used to identify temperature thresholds for mapping temperature‐related snow drought susceptibility. Results highlight spatial differences in snow drought regimes across sWNA and reveal that temperature thresholds exist at −3.1 °C (±0.3 °C) and 1.4 °C (±0.3 °C), above which the warm snow drought risk increases more rapidly. Approximately 3% of the nonglaciated snow storage in this region has high susceptibility to temperature‐related snow drought, representing 11 km3 of water, or approximately one third the capacity of Lake Mead. Under a +2 °C climate scenario, an additional 8% (28 km3) of this snow storage volume will transition to high susceptibility.
Geographical Evolution of Agricultural Production in China and Its Effects on Water Stress, Economy, and the Environment: The Virtual Water Perspective
Authors: Sun S. K. , Yin Y. L. , Wu P. T. , Wang Y. B. , Luan X. B. , Li C.
Published: March 2019

Agricultural production is accompanied by a large amount of water consumption, nonpoint source pollution, and greenhouse gas emissions. However, the comprehensive and quantitative analysis of associated impacts on regional water, the environment, and the economy caused by variations in agricultural distribution is insufficient. This paper evaluates the evolution of grain production distribution and its effects on water resources, the economy, and the environment in China by using virtual water theory. The results show that the grain production area located in northern China is characterized by scarce water resources and a less developed economy. Due to the imbalance between grain supply and demand, virtual water embedded in grain will transfer among regions. These flows have formed a pattern where virtual water transfers from the water‐scarce northern region to the water‐rich southern region, increasing from 72.99 Gm3 in 1997 to 124.64 Gm3 in 2014. Evolution of grain production distribution changes the spatial pattern of grain production and consumption, and it exacerbates water resource pressure, the gray water footprint, and greenhouse gas emissions in the area that exports grain virtual water. The gray water footprint and carbon emissions in the grain export area increased by 10.66% and 31.06% during the study period, respectively. Meanwhile, the distribution of regional grain production influences the allocation of water resources in agriculture and other industries. Due to the difference between the economic benefits created by industry and agriculture, grain virtual water flow will have effects on the regional economic development.
A Simplified Model of Water Vapor Exchange in the Amazon
Authors: Sidder Aaron
Published: March 2019

Evapotranspiration is the exchange of water vapor between land and the atmosphere, and it is hard to measure and model. A new study shows promise for its estimation over large, vegetated landscapes.
Atypical plant homeodomain of UBR7 functions as an H2BK120Ub ligase and breast tumor suppressor
Authors: Adhikary Santanu , Chakravarti Deepavali , Terranova Christopher , Sengupta Isha , Maitituoheti Mayinuer , Dasgupta Anirban , Srivastava Dushyant Kumar , Ma Junsheng , Raman Ayush T. , Tarco Emily , Sahin Aysegul A. , Bassett Roland , Yang Fei , Tapia Coya , Roy Siddhartha , Rai Kunal , Das Chandrima
Published: March 2019

The roles of Plant Homeodomain (PHD) fingers in catalysis of histone modifications are unknown. We demonstrated that the PHD finger of Ubiquitin Protein Ligase E3 Component N-Recognin7 (UBR7) harbors E3 ubiquitin ligase activity toward monoubiquitination of histone H2B at lysine120 (H2BK120Ub). Purified PHD finger or full-length UBR7 monoubiquitinated H2BK120 in vitro, and loss of UBR7 drastically reduced H2BK120Ub genome-wide binding sites in MCF10A cells. Low UBR7 expression was correlated with occurrence of triple-negative breast cancer and metastatic tumors. Consistently, UBR7 knockdown enhanced the invasiveness, induced epithelial-to-mesenchymal transition and promoted metastasis. Conversely, ectopic expression of UBR7 restored these cellular phenotypes and reduced tumor growth. Mechanistically, UBR7 loss reduced H2BK120Ub levels on cell adhesion genes, including CDH4, and upregulated the Wnt/β-Catenin signaling pathway. CDH4 overexpression could partially revert UBR7-dependent cellular phenotypes. Collectively, our results established UBR7 as a histone H2B monoubiquitin ligase that suppresses tumorigenesis and metastasis of triple-negative breast cancer.
Functional ultrasound imaging of the brain reveals propagation of task-related brain activity in behaving primates
Authors: Dizeux Alexandre , Gesnik Marc , Ahnine Harry , Blaize Kevin , Arcizet Fabrice , Picaud Serge , Sahel José-Alain , Deffieux Thomas , Pouget Pierre , Tanter Mickael
Published: March 2019

Neuroimaging modalities such as MRI and EEG are able to record from the whole brain, but this comes at the price of either limited spatiotemporal resolution or limited sensitivity. Here, we show that functional ultrasound imaging (fUS) of the brain is able to assess local changes in cerebral blood volume during cognitive tasks, with sufficient temporal resolution to measure the directional propagation of signals. In two macaques, we observed an abrupt transient change in supplementary eye field (SEF) activity when animals were required to modify their behaviour associated with a change of saccade tasks. SEF activation could be observed in a single trial, without averaging. Simultaneous imaging of anterior cingulate cortex and SEF revealed a time delay in the directional functional connectivity of 0.27 ± 0.07 s and 0.9 ± 0.2 s for both animals. Cerebral hemodynamics of large brain areas can be measured at high spatiotemporal resolution using fUS.
Gene expression over the course of schizophrenia: from clinical high-risk for psychosis to chronic stages
Authors: Ota Vanessa Kiyomi , Moretti Patricia Natalia , Santoro Marcos Leite , Talarico Fernanda , Spindola Leticia Maria , Xavier Gabriela , Carvalho Carolina Muniz , Marques Diogo Ferri , Costa Giovany Oliveira , Pellegrino Renata , de Jong Simone , Cordeiro Quirino , Hakonarson Hakon , Breen Gerome , Noto Cristiano , Bressan Rodrigo Affonseca , Gadelha Ary , Jesus Mari Jair de , Belangero Sintia I.
Published: March 2019

The study of patients with schizophrenia (SZ) at different clinical stages may help clarify what effects could be due to the disease itself, to the pharmacological treatment, or to the disease progression. We compared expression levels of targeted genes in blood from individuals in different stages of SZ: clinical high risk for psychosis (CHR), first episode of psychosis (FEP), and chronic SZ (CSZ). Then, we further verified whether single-nucleotide polymorphisms (SNPs) could be related to gene expression differences. We investigated 12 genes in 394 individuals (27 individuals with CHR, 70 antipsychotic-naive individuals with FEP, 157 CSZ patients, and 140 healthy controls (HCs)). For a subsample, genotype data were also available, and we extracted SNPs that were previously associated with the expression of selected genes in whole blood or brain tissue. We generated a mediation model in which a putative cause (SNP) is related to a presumed effect (disorder) via an intermediate variable (gene expression). MBP and NDEL1 were upregulated in FEP compared to all other groups; DGCR8 was downregulated in FEP compared to HC and CHR; DGCR2 was downregulated in CSZ compared to FEP and HCs; DISC1 was upregulated in schizophrenia compared to controls or FEP, possibly induced by the rs3738398 and rs10864693 genotypes, which were associated with DISC1 expression; and UFD1 was upregulated in CSZ and CHR compared to FEP and HC. Our results indicated changes in gene expression profiles throughout the different clinical stages of SZ, reinforcing the need for staging approaches to better capture SZ heterogeneity.
Retraction Note: TET2 inhibits tumorigenesis of breast cancer cells by regulating caspase-4
Authors: Zhu Xuguo , Li Shuangqi
Published: March 2019

This paper has been retracted at the request of the authors.
Regulation of liver receptor homologue-1 by DDB2 E3 ligase activity is critical for hepatic glucose metabolism
Authors: Lai Tsai-Chun , Hu Meng-Chun
Published: March 2019

Liver receptor homologue-1 (LRH-1) plays a critical role in hepatic metabolism and disease. Here we show that LRH-1 protein stability is regulated by the cullin 4 (CUL4) E3 ubiquitin ligase complex. We found that DNA damage-binding protein 2 (DDB2) directly interacts with LRH-1 and functions as a substrate recognition component of CUL4-DDB1 to promote LRH-1 ubiquitination and proteasomal degradation. In human hepatoma (HepG2) cells, we observed that protein levels of endogenous LRH-1 are increased by insulin without a change in mRNA levels of LRH-1. However, overexpression of DDB2 impaired the insulin-stimulated increase in LRH-1 levels. In addition, DDB2 overexpression decreased LRH-1 transcriptional activation and expression of target genes, such as glucokinase, whereas knockdown of DDB2 increased the expression of glucokinase. Finally, we demonstrated that DDB2 knockdown increases glucose uptake and intracellular levels of glucose-6-phosphate in HepG2 cells. Our study reveals a novel regulatory mechanism of LRH-1 activity and suggests a role for DDB2 in hepatic glucose metabolism.
RNA interference-mediated knockdown of voltage-gated sodium channel (MpNav) gene causes mortality in peach-potato aphid, Myzus persicae
Authors: Tariq Kaleem , Ali Asad , Davies T. G. Emyr , Naz Erum , Naz Laila , Sohail Summar , Hou Maolin , Ullah Farman
Published: March 2019

Voltage-gated sodium channels (VGSC) are transmembrane proteins that generate an action potential in excitable cells and play an essential role in neuronal signaling. Since VGSCs play a crucial role in nerve transmission they have become primary targets for a broad range of commercial insecticides. RNA interference (RNAi) is a valuable reverse genetics tool used in functional genomics, but recently, it has also shown promise as a novel agent that could be used to control agricultural insect pests. In this study, we targeted the VGSC (MpNav) gene in the peach-potato aphid Myzus persicae, by oral feeding of artificial diets mixed with dsRNAs. Knock-down of MpNav gene expression caused up to 65% mortality in 3rd instar nymphs. Moreover, significantly lower fecundity and longevity was observed in adult aphids that had been fed with dsMpNav solution at the nymphal stage. Analysis of gene expression by qRT-PCR indicated that the aphid mortality rates and the lowered fecundity and longevity were attributable to the down-regulation of MpNav by RNAi. Taken together, our results show that MpNav is a viable candidate target gene for the development of an RNAi-based bio-aphicide.
Propagation of Subseasonal Equatorially-Forced Coastal Trapped Waves down to the Benguela Upwelling System
Authors: Illig Serena , Bachèlery Marie-Lou
Published: March 2019

The oceanic connection between the coastal variability along the southwestern African coasts and the linear equatorial dynamics at subseasonal time-scales (<120 days) is examined using a variety of model outputs, ranging from linear to general circulation models. We focus on the equatorially-forced fast and weakly dissipative first-mode coastal trapped waves which are shown to propagate down to the southern tip of Africa. In the eastern equatorial Atlantic, the first-mode equatorial forcing is tangled with the higher-order Kelvin wave modes and is overshadowed by the dominant second baroclinic mode. The latter is slower and peaks 10 days after the concealed first-mode contribution. Within this time frame, the remotely-forced first-mode coastal trapped waves impinge on the variability of the Benguela upwelling ecosystem, almost in phase with the subseasonal sea level fluctuations in the Gulf of Guinea. Over 1993–2008, the equatorial forcing undergoes a substantial interannual modulation. Periods of energetic first-mode equatorial Kelvin waves coincide with a strong subseasonal coastal wind activity that breaks the stronger equatorial connection. This suggests the existence of a large-scale atmospheric connection between the equatorial wave forcing and the along-shore winds in the Benguela, modulating the maximum latitude at which the equatorial dynamics impacts the local marine resources.
Intermolecular interactions in crystals of benzene and its mono- and dinitro derivatives: study from the energetic viewpoint
Authors: Konovalova Irina S. , Shishkina Svitlana V. , Bani-Khaled G. , Muzyka Ekaterina N. , Boyko Alexander N.
Published: March 2019

The weak intermolecular interactions and their role in mono- and dinitrobenzene crystal structure formation have been studied using quantum-chemical calculations.
Emerging investigator series: atmospheric cycling of indium in the northeastern United States
Authors: White Sarah Jane O. , Hemond Harold F.
Published: March 2019

Atmospheric indium is dominated by human emissions, primarily from coal combustion and the smelting of lead, zinc, and other metal sulfides.
Advances in energy systems for valorization of aqueous byproducts generated from hydrothermal processing of biomass and systems thinking
Authors: Gu Yexuan , Zhang Xuesong , Deal Brian , Han Lujia , Zheng Jilu , Ben Haoxi
Published: March 2019

Advances in energy systems for the valorization of the aqueous byproduct generated from the hydrothermal processing of biomass: a perspective and review of the recent progress.
Gel-on-a-chip: continuous, velocity-dependent DNA separation using nanoscale lateral displacement
Authors: Wunsch Benjamin H. , Kim Sung-Cheol , Gifford Stacey M. , Astier Yann , Wang Chao , Bruce Robert L. , Patel Jyotica V. , Duch Elizabeth A. , Dawes Simon , Stolovitzky Gustavo , Smith Joshua T.
Published: March 2019

We studied the dsDNA trajectories being advected while diffusing in a pressure driven flow in a nanoDLD array.
Reversible photo-induced doping in WSe2 field effect transistors
Authors: Luo Xuyi , Andrews Kraig , Wang Tianjiao , Bowman Arthur , Zhou Zhixian , Xu Ya-Qiong
Published: March 2019

We report a reversible photo-induced doping effect in two-dimensional (2D) tungsten diselenide (WSe2) field effect transistors on hexagonal boron nitride (h-BN) substrates under low-intensity visible light illumination (∼10 nW μm−2).