bluuebunny/crossref_metadata_2025 huggingface dataset:
Rerouting of NADPH synthetic pathways for increased protopanaxadiol production in Saccharomyces cerevisiae
Authors: Kim Jae-Eung , Jang In-Seung , Sung Bong Hyun , Kim Sun Chang , Lee Ju Young
Published: October 2018

Ginseng (Panax ginseng) and its bioactive components, ginsenosides, are popular medicinal herbal products, exhibiting various pharmacological effects. Despite their advocated use for medication, the long cultivation periods of ginseng roots and their low ginsenoside content prevent mass production of this compound. Yeast Saccharomyces cerevisiae was engineered for production of protopanaxadiol (PPD), a type of aglycone characterizing ginsenoside. PPD-producing yeast cell factory was further engineered by obtaining a balance between enzyme expressions and altering cofactor availability. Different combinations of promoters (PGPD, PCCW12, and PADH2) were utilized to construct the PPD biosynthetic pathway. Rerouting the redox metabolism to improve NADPH availability in the engineered S. cerevisiae also increased PPD production. Combining these approaches resulted in more than an 11-fold increase in PPD titer over the initially constructed strain. The series of metabolic engineering strategies of this study provides a feasible approach for the microbial production of PPD and development of microbial platforms producing other industrially-relevant terpenoids.
Digital Domain Power Division Multiplexed Dual Polarization Coherent Optical OFDM Transmission
Authors: Wu Qiong , Feng Zhenhua , Tang Ming , Li Xiang , Luo Ming , Zhou Huibin , Fu Songnian , Liu Deming
Published: October 2018

Capacity is the eternal pursuit for communication systems due to the overwhelming demand of bandwidth hungry applications. As the backbone infrastructure of modern communication networks, the optical fiber transmission system undergoes a significant capacity growth over decades by exploiting available physical dimensions (time, frequency, quadrature, polarization and space) of the optical carrier for multiplexing. For each dimension, stringent orthogonality must be guaranteed for perfect separation of independent multiplexed signals. To catch up with the ever-increasing capacity requirement, it is therefore interesting and important to develop new multiplexing methodologies relaxing the orthogonal constraint thus achieving better spectral efficiency and more flexibility of frequency reuse. Inspired by the idea of non-orthogonal multiple access (NOMA) scheme, here we propose a digital domain power division multiplexed (PDM) transmission technology which is fully compatible with current dual polarization (DP) coherent optical communication system. The coherent optical orthogonal frequency division multiplexing (CO-OFDM) modulation has been employed owing to its great superiority on high spectral efficiency, flexible coding, ease of channel estimation and robustness against fiber dispersion. And a PDM-DP-CO-OFDM system has been theoretically and experimentally demonstrated with 100 Gb/s wavelength division multiplexing (WDM) transmission over 1440 km standard single mode fibers (SSMFs).
Magnetic Resonance Imaging for tracking cellular patterns obtained by Laser-Assisted Bioprinting
Authors: Kérourédan Olivia , Ribot Emeline Julie , Fricain Jean-Christophe , Devillard Raphaël , Miraux Sylvain
Published: October 2018

Recent advances in the field of Tissue Engineering allowed to control the three-dimensional organization of engineered constructs. Cell pattern imaging and in vivo follow-up remain a major hurdle in in situ bioprinting onto deep tissues. Magnetic Resonance Imaging (MRI) associated with Micron-sized superParamagnetic Iron Oxide (MPIO) particles constitutes a non-invasive method for tracking cells in vivo. To date, no studies have utilized Cellular MRI as a tool to follow cell patterns obtained via bioprinting technologies. Laser-Assisted Bioprinting (LAB) has been increasingly recognized as a new and exciting addition to the bioprinting’s arsenal, due to its rapidity, precision and ability to print viable cells. This non-contact technology has been successfully used in recent in vivo applications. The aim of this study was to assess the methodology of tracking MPIO-labeled stem cells using MRI after organizing them by Laser-Assisted Bioprinting. Optimal MPIO concentrations for tracking bioprinted cells were determined. Accuracy of printed patterns was compared using MRI and confocal microscopy. Cell densities within the patterns and MRI signals were correlated. MRI enabled to detect cell patterns after in situ bioprinting onto a mouse calvarial defect. Results demonstrate that MRI combined with MPIO cell labeling is a valuable technique to track bioprinted cells in vitro and in animal models.
Competition between green self-trapped-exciton and red non-bridging-oxygen emissions in SiO2 under interband excitation
Authors: Paleari Alberto , Meinardi Francesco , Brovelli Sergio , Lorenzi Roberto
Published: October 2018

The knowledge advancement in the physics of silicon dioxide has promoted ground-breaking progress, from microelectronics to fibre optics. However, the SiO2 exciton decay mechanism is still mostly unrevealed. Here, we analyse the temperature dependence of interband-excited luminescence and the reflectivity by means of synchrotron radiation on a wide selection of SiO2 materials. This enables us to decouple the band-to-band recombination steps from non-radiative decay pathways that typically mask the relaxation mechanisms. We show that band-to-band excitations decay into two competitive correlated channels leading to green and red luminescence so far ascribed to independent transitions. Here we discuss the assignment to a dual relaxation route involving either ‘free’ or ‘interacting’ non-bridging-oxygen sites. Such an interpretation suggests an explanation for the elusive non-bridging-oxygen centres in quartz. The reflectivity spectra finally demonstrates a general relationship between exciton spectral position and bandwidth in SiO2 and clarifies the role of disorder in exciton localization.
A novel fluorescent probe for Hg2+ detection in a wide pH range and its application in living cell imaging
Authors: Xu Jing , Li Honglin , Chen Yanchi , Yang Bing , Jiao Qingcai , Yang Yushun , Zhu Hai-Liang
Published: October 2018

A novel fluorescent probe (XL-1) exhibited over 50-fold enhanced fluorescence in the presence of Hg2+ and no interference could be produced by other metal ions, anions and amino acids.
Construction of an Fe, N and S-codoped ultra-thin carbon nanosheet superstructure for the oxygen reduction reaction
Authors: Wang Yu , Guo Ningning , Zhu Liangkui , Pan Ying , Wang Runwei , Zhang Zongtao , Qiu Shilun
Published: October 2018

A novel 3D superstructure containing Fe, N, and S-codoped ultra-thin carbon nanosheets was prepared to serve as a superior ORR electrocatalyst.
Chemoproteomic fishing identifies arzanol as a positive modulator of brain glycogen phosphorylase
Authors: del Gaudio Federica , Pollastro Federica , Mozzicafreddo Matteo , Riccio Raffaele , Minassi Alberto , Monti Maria Chiara
Published: October 2018

Arzanol, a natural compound with an intriguing structure, fished out brain glycogen phosphorylase as its main target, promoting enzyme activity.
An oxaliplatin(iv) prodrug-based supramolecular self-delivery nanocarrier for targeted colorectal cancer treatment
Authors: Lim Wei Qi , Phua Soo Zeng Fiona , Chen Hongzhong , Zhao Yanli
Published: October 2018

A two-component supramolecular prodrug nanocarrier fabricated via self-assembly presents redox-responsive drug release with cancer cell-targeting capability, showing enhanced efficiency for colorectal cancer treatment.
Probing spatial coupling of resistive modes in porous intercalation electrodes through impedance spectroscopy
Authors: Mistry Aashutosh N. , Mukherjee Partha P.
Published: October 2018

The spatial coupling between the pore-scale microstructural resistances and the electrode-scale measurements is detailed via a physics-based, mechanistic description.
Synthesis and physicochemical characterization of beta zeolite–bentonite composite materials for shaped catalysts
Authors: Vajglová Zuzana , Kumar Narendra , Peurla Markus , Peltonen Janne , Heinmaa Ivo , Murzin Dmitry Yu.
Published: October 2018

Composite materials for shaped catalysts were prepared from three commercial beta zeolites using bentonite as an aluminosilicate clay binder.
The development of a new approach toward lanthanide-based OLED fabrication: new host materials for Tb-based emitters
Authors: Aslandukov Andrey N. , Utochnikova Valentina V. , Goriachiy Dmitry O. , Vashchenko Andrey A. , Tsymbarenko Dmitry M. , Hoffmann Michael , Pietraszkiewicz Marek , Kuzmina Natalia P.
Published: October 2018

The use of electron-transport triphenylphosphine oxide derivatives as host materials, which are able to sensitize terbium luminescence, resulted in successful use of Tb-based emitters in OLED.
The structurally variable network of spin couplings and migrating paramagnetic centers in binuclear o-quinone CoII complexes with biradical acene linkers: a computational DFT study
Authors: Minkin Vladimir I. , Starikov Andrey G. , Starikova Alyona A. , Minyaev Ruslan M. , Boldyrev Alexander I.
Published: October 2018

Binuclear cobalt complexes with acene linkers functionalized with o-quinone moieties may undergo intramolecular electron transfers.
Diverse modes of functionalisation of ruthenium coordinated β-ketoiminate analogues
Authors: Bera Sudip Kumar , Panda Sanjib , Dey Baksi Sourajit , Lahiri Goutam Kumar
Published: October 2018

Varying chelation assisted as well as solvent dependent reactivity profiles of isostructural β-ketoiminate analogues explicate their non-spectator behaviour and fractional redox non-innocence.
Synthesis of quinolinyl-based pincer copper(ii) complexes: an efficient catalyst system for Kumada coupling of alkyl chlorides and bromides with alkyl Grignard reagents
Authors: Pandiri Hanumanprasad , Gonnade Rajesh G. , Punji Benudhar
Published: October 2018

Well-defined quinolinamide-based pincer copper complexes have been developed and demonstrated in the Kumada coupling reaction of nonactivated alkyl chlorides and bromides with alkyl magnesium chloride.
Humidity-induced CO2 capture enhancement in Mg-CUK-1
Authors: Sagastuy-Breña Mónica , Mileo Paulo G. M. , Sánchez-González Elí , Reynolds Joseph E. , Jurado-Vázquez Tamara , Balmaseda Jorge , González-Zamora Eduardo , Devautour-Vinot Sabine , Humphrey Simon M. , Maurin Guillaume , Ibarra Ilich A.
Published: October 2018

Mg-CUK-1 showed a 1.8-fold increase in CO2 capture (from 4.6 wt% to 8.5 wt%) in the presence of 18% RH.
Recent advances in the development of luminescent lanthanide-based supramolecular polymers and soft materials
Authors: Kotova Oxana , Bradberry Samuel J. , Savyasachi Aramballi J. , Gunnlaugsson Thorfinnur
Published: October 2018

Here we discuss the emerging field of luminescent lanthanide-based soft materials with our focus on the different approaches used for their design and synthesis as well as manipulations of their functional properties.
Vapor-fumigation for record efficiency two-dimensional perovskite solar cells with superior stability
Authors: Zhu Xuejie , Xu Zhuo , Zuo Shengnan , Feng Jiangshan , Wang Ziyu , Zhang Xiaorong , Zhao Kui , Zhang Jian , Liu Hairui , Priya Shashank , Liu Shengzhong Frank , Yang Dong
Published: October 2018

The record efficiency of a two-dimensional perovskite solar cell reaches 16.92% (certified at 16.6%) with excellent stability using a vapor-fumigation technique.
Direct visible light activation of a surface cysteine-engineered [NiFe]-hydrogenase by silver nanoclusters
Authors: Zhang Liyun , Beaton Stephen E. , Carr Stephen B. , Armstrong Fraser A.
Published: October 2018

Engineering a cysteine close to the distal [4Fe–4S] cluster of a [NiFe]-hydrogenase creates a specific target for Ag nanoclusters, the resulting ‘hard-wired’ enzyme catalyzing rapid hydrogen evolution by visible light.
Behavior of silver nanoparticles in wastewater: systematic investigation on the combined effects of surfactants and electrolytes in model systems
Authors: Capjak Ivona , Zebić Avdičević Maja , Sikirić Maja Dutour , Domazet Jurašin Darija , Hozić Amela , Pajić Damir , Dobrović Slaven , Goessler Walter , Vinković Vrček Ivana
Published: October 2018

pH, electrolytes and surfactants affected the stability of AgNPs in artificial test water system.
Evaluating the membrane fouling formation and chemical cleaning strategy in forward osmosis membrane filtration treating domestic sewage
Authors: Ab Hamid Nur Hafizah , Ye Liu , Wang David K. , Smart Simon , Filloux Emmanuelle , Lebouteiller Thibault , Zhang Xiwang
Published: October 2018

Free nitrous acid (FNA) shows strong potential as an effective cleaning reagent in fouling control in a forward osmosis filtration system, with a relatively longer time required.
Deoxycholic acid disrupts the intestinal mucosal barrier and promotes intestinal tumorigenesis
Authors: Liu Li , Dong Wenxiao , Wang Sinan , Zhang Yujie , Liu Tianyu , Xie Runxiang , Wang Bangmao , Cao Hailong
Published: October 2018

Deoxycholic acid (DCA) induced intestinal low grade inflammation and disrupted the mucosal physical and functional barriers, aggravating intestinal tumorigenesis.
Discrimination between ionic silver and silver nanoparticles in consumer products using graphite furnace atomic absorption spectrometry
Authors: Gruszka Jakub , Zambrzycka-Szelewa Elżbieta , Kulpa Janusz S. , Godlewska-Żyłkiewicz Beata
Published: October 2018

GFAAS method allows for rapid discrimination between Ag+ and AgNPs of different size extracted from fabrics and hygiene products.
Preparation of NIR absorbing axial substituted tin(iv) porphyrins and their photocytotoxic properties
Authors: Babu Balaji , Amuhaya Edith , Oluwole David , Prinsloo Earl , Mack John , Nyokong Tebello
Published: October 2018

The photophysical properties and photodynamic therapy (PDT) activity of an axially ligated meso-thienyl Sn(iv) porphyrin are investigated.
Synthesis and anticonvulsant activity of phenoxyacetyl derivatives of amines, including aminoalkanols and amino acids
Authors: Pańczyk Katarzyna , Żelaszczyk Dorota , Koczurkiewicz Paulina , Słoczyńska Karolina , Pękala Elżbieta , Żesławska Ewa , Nitek Wojciech , Żmudzki Paweł , Marona Henryk , Waszkielewicz Anna
Published: October 2018

17 new phenoxyacetamides have been prepared via chemical synthesis and screened for potential anticonvulsant activity.
Selenium deficiency induces splenic growth retardation by deactivating the IGF-1R/PI3K/Akt/mTOR pathway
Authors: Wang Jianfa , Lian Shuai , He Xianjing , Yu Debin , Liang Jianbin , Sun Dongbo , Wu Rui
Published: October 2018

Selenium (Se) deficiency impairs the development and function of immune system in human beings and animals.
Is copper a new target to counteract the progression of chronic diseases?
Authors: Balsano Clara , Porcu Cristiana , Sideri Silvia
Published: October 2018

In this review, we highlight the importance of a Cu imbalance in the pathogenesis of several chronic inflammatory diseases.
A fullerene helical peptide: synthesis, characterization and formation of self-assembled monolayers on gold surfaces
Authors: Nasrallah Houssein , Rabah Jad , Bui-Thi-Tuyet Van , Baczko Krystyna , Fensterbank Hélène , Bourdreux Flavien , Goncalves Anne-Marie , Declerck Valérie , Boujday Souhir , Humblot Vincent , Wright Karen , Vallée Anne , Allard Emmanuel
Published: October 2018

A helical C60-peptide allowed the formation of well-packed SAMs compared to a C60-alkyl peptide, which was determined by QCM and CV experiments.
Trimetallic PtPdCu nanowires as an electrocatalyst for methanol and formic acid oxidation
Authors: Wang Peng , Zhang Yuanyuan , Shi Rui , Wang Zhenghua
Published: October 2018

PtPdCu nanowires show enhanced electrocatalytic activity and stability compared to their bimetallic counterparts and commercial Pt/C.
Recent advances in one-dimensional halide perovskites for optoelectronic applications
Authors: Qiu Ting , Hu Yanqiang , Xu Feng , Yan Zhong , Bai Fan , Jia Guohua , Zhang Shufang
Published: October 2018

This article reviews the achievements in synthesis techniques and nanoscale optoelectronic applications based on one-dimensional metal–halide perovskite nanocrystals.
On-demand concentration of an analyte on laser-printed polytetrafluoroethylene
Authors: Zhizhchenko Alexey , Kuchmizhak Aleksandr , Vitrik Oleg , Kulchin Yuri , Juodkazis Saulius
Published: October 2018

Textured surfaces with non-uniform wettability allow the achievement of extremely high values of analyte concentration in an evaporating droplet for ultrasensitive detection systems.
Nanoclusters of crystallographically aligned nanoparticles for magnetic thermotherapy: aqueous ferrofluid, agarose phantoms andex vivomelanoma tumour assessment
Authors: Coral D. F. , Soto P. A. , Blank V. , Veiga A. , Spinelli E. , Gonzalez S. , Saracco G. P. , Bab M. A. , Muraca D. , Setton-Avruj P. C. , Roig A. , Roguin L. , Fernández van Raap M. B.
Published: October 2018

An integrated approach to advance in the translation of magnetic hyperthermia to clinical uses is described.
Nanoscale LuFeO3: shape dependent ortho/hexa-phase constitution and nanogenerator application
Authors: Chaturvedi Smita , Singh Sachin Kumar , Shyam Priyank , Shirolkar Mandar M. , Krishna Swathi , Boomishankar R. , Ogale Satishchandra
Published: October 2018

Ferroelectric and nanogenerator response of ortho and hexa-mixed phase LuFeO3 nanoparticles and nanofibers embedded in a PDMS matrix.
One-pot synthesis of monodisperse dual-functionalized polyethylene glycols through macrocyclic sulfates
Authors: Lv Xiaoyan , Zheng Xing , Yang Zhigang , Jiang Zhong-Xing
Published: October 2018

Cyclic sulfate chemistry was expanded to dual-nucleophilic substitution, which provides valuable dual-functionalized monodisperse polyethylene glycols with high efficacy.
Photoresponsive supramolecular polymers based on quadruple hydrogen-bonding and a photochromic azobenzene motif
Authors: Tan Shaobo , Sha Ye , Zhu Tianyu , Rahman Md Anisur , Tang Chuanbing
Published: October 2018

A photoresponsive quadruple hydrogen-bonded supramolecular polymer was constructed using photochromic azobenzene and ureidopyrimidinone motifs.
Visible-light-mediated allylation of alkyl radicals with allylic sulfones via a deaminative strategy
Authors: Zhang Miao-Miao , Liu Feng
Published: October 2018

A mild and simple protocol is developed for the synthesis of terminal alkenes via site-specific C–C bond formation upon visible-light irradiation.
Enhanced distance-dependent fluorescence quenching using size tuneable core shell silica nanoparticles
Authors: Elsutohy Mohamed M. , Selo Amjad , Chauhan Veeren M. , Tendler Saul J. B. , Aylott Jonathan W.
Published: October 2018

Core–shell silica nanoparticles were shown to demonstrate quenching between a fluorescent core and surface black hole quencher layer, separated by a size controllable silica shell.
Quantitative analysis of the distribution and mixing of cellulose nanocrystals in thermoplastic composites using Raman chemical imaging
Authors: Lewandowska Anna E. , Inai Nor H. , Ghita Oana R. , Eichhorn Stephen J.
Published: October 2018

Raman chemical imaging is presented to both quantify the dispersion and the degree of mixing in a cellulose nanocrystal composite.
Retention and diffusion of transmutation H and He atoms in Be12Ti: first-principles calculations
Authors: Zhu Xiaolu , Wang Canglong , Liu Jiajia , Zhang Xingming , Deng Huiqiu , Duan Wenshan , Yang Lei
Published: October 2018

In this work, first-principles calculations were conducted to gain insight into the retention and diffusion behavior of transmutation H and He atoms in Be12Ti.
Enhanced electrochemical response of a modified glassy carbon electrode by poly(2-vinlypyridine-b-methyl methacrylate) conjugated gold nanoparticles for detection of nicotine
Authors: Rahim Sana , Rauf Asma , Rauf Saba , Shah Muhammad Raza , Malik Muhammad Imran
Published: October 2018

Poly(2-vinylpyridine-b-methylmethacrylate) coated gold nanoparticles [P(2VP-MMA)-AuNPs] are employed for enhancement of electrochemical response of glassy carbon electrode for nicotine.
The sequential structure of tripyridiniumylporphyrin pendants in water-soluble copolymers and their association behaviour with tetrasulfonatophenylporphyrin guests: UV-vis absorption and fluorescence emission spectra study
Authors: Ding Ke-Wei , Li Tao-Qi , Ge Zhong-Xue , Bu Jian-Hua , Liu Ying
Published: October 2018

Water-soluble random and micro-blocky copolymers P(ZnTrMPyP-AM) were prepared and the porphyrin pendants on them associate with anionic porphyrins in different manner.
Synthesis and biological evaluation of phosphatidylcholines with cinnamic and 3-methoxycinnamic acids with potent antiproliferative activity
Authors: Czarnecka Marta , Świtalska Marta , Wietrzyk Joanna , Maciejewska Gabriela , Gliszczyńska Anna
Published: October 2018

A series of eight novel phosphatidylcholines containing CA or 3-OMe-CA acids (3a-b,5a-b,9a-b,10a-b) atsn-1 and/orsn-2 positions were synthesized and tested for their antiproliferative activity against selected cancer cell lines.
Solution processed organic light-emitting diodes using a triazatruxene crosslinkable hole transporting material
Authors: Babaei Azin , Rakstys Kasparas , Guelen Simon , Fallah Hamidabadi Vahid , La-Placa Maria-Grazia , Martínez-Sarti Laura , Sessolo Michele , Joel Huckaba Aron , Gaudin Olivier P. M. , Schanen Vincent , Nazeeruddin Mohammad Khaja , Bolink Henk J.
Published: October 2018

A cross-linkable triazatruxene that leads to insoluble films upon thermal annealing at temperatures compatible with flexible substrates is presented.
Fast and safe synthesis of micron germanium in an ammonia atmosphere using Mo2N as catalyst
Authors: Ma Baojun , Li Dekang , Wang Xiaoyan , Lin Keying
Published: October 2018

Here, we reported a new method for fast and safe synthesis of a micron germanium (Ge) semiconductor.
Theranostic nanocomposite from upconversion luminescent nanoparticles and black phosphorus nanosheets
Authors: Dibaba Solomon Tiruneh , Wei Ruoyan , Xi Wensong , Zhao Lei , Shi Liyi , Ren Wei , Mayr Torsten , Sun Lining
Published: October 2018

We successfully synthesized a multifunctional theranostic nanocomposite from upconversion nanoparticles and black phosphorus nanosheets for synergistic photothermal/photodynamic therapies in vitro and dual modal imaging.
An efficient one-pot conversion of carboxylic acids into benzimidazoles via an HBTU-promoted methodology
Authors: Barasa Leonard , Yoganathan Sabesan
Published: October 2018

A mild, one-pot and HBTU-promoted method for the synthesis of structurally diverse benzimidazoles is reported, exhibiting a broad substrate scope.
Topological self-template directed synthesis of multi-shelled intermetallic Ni3Ga hollow microspheres for the selective hydrogenation of alkyne
Authors: Hu Mingzhen , Yang Wenjuan , Liu Shoujie , Zhu Wei , Li Yang , Hu Botao , Chen Zheng , Shen Rongan , Cheong Weng-Chon , Wang Yu , Zhou Kebin , Peng Qing , Chen Chen , Li Yadong
Published: October 2018

The Well-defined multi-shelled intermetallic Ni3Ga hollow microspheres were firstly prepared with attractive properties.
Tailored homo- and hetero- lanthanide porphyrin dimers: a synthetic strategy for integrating multiple spintronic functionalities into a single molecule
Authors: Le Roy Jennifer J. , Cremers Jonathan , Thomlinson Isabel A. , Slota Michael , Myers William K. , Horton Peter H. , Coles Simon J. , Anderson Harry L. , Bogani Lapo
Published: October 2018

We present molecular magnetic systems that contain all elements necessary for spin-valve control in molecular spintronic devices in a single molecule.
Length segregation in mixtures of spherocylinders induced by imposed topological defects
Authors: Allahyarov Elshad , Löwen Hartmut
Published: October 2018

We explore length segregation in binary mixtures of spherocylinders of lengthsL1andL2which are tangentially confined on a spherical surface of radiusR.
On the role of hydroxide species in sulphur- and nitrogen-doped cobalt-based carbon catalysts for the oxygen evolution reaction
Authors: Shahraei Ali , Kuebler Markus , Martinaiou Ioanna , Creutz K. Alexander , Wallace W. David Z. , Nowroozi Mohammad A. , Paul Stephen , Weidler Natascha , Stark Robert W. , Clemens Oliver , Kramm Ulrike I.
Published: October 2018

Cobalt hydroxide species are at the origin of OER activity of multiheteroatom doped carbon catalysts.
Omnidirectional and effective salt-rejecting absorber with rationally designed nanoarchitecture for efficient and durable solar vapour generation
Authors: Song Xiaoying , Song Hucheng , Xu Ning , Yang Huafeng , Zhou Lin , Yu Linwei , Zhu Jia , Xu Jun , Chen Kunji
Published: October 2018

Harvesting solar energy as heat has shown fascinating applications for the purification of polluted or saline water to address the water scarcity issue globally.
Mussel-inspired polydopamine chemistry to modulate template synthesis of 1D metal–organic framework superstructures
Authors: Yu Boxuan , Ye Gang , Zeng Zhen , Zhang Lei , Chen Jing , Ma Shengqian
Published: October 2018

Novel contra-diffusion synthesis of diverse 1D MOF superstructures in the channels of polycarbonate track-etched membranes regulated by a substrate-involving catalytic transesterification mechanism or mediated by mussel-inspired polydopamine chemistry.
A facile synthesis tool of nanoporous carbon for promising H2, CO2, and CH4 sorption capacity and selective gas separation
Authors: Park Jaewoo , Jung Minji , Jang Haenam , Lee Kiyoung , Attia Nour F. , Oh Hyunchul
Published: October 2018

Highly efficient activated carbon prepared from renewable resources that has an excellent storage capacity for various gases (H2, CH4, and CO2).
Cancer-targeted reactive oxygen species-degradable polymer nanoparticles for near infrared light-induced drug release
Authors: Seah Geok Leng , Yu Jeong Heon , Koo Bon Il , Lee Dong Jae , Nam Yoon Sung
Published: October 2018

Nanocarriers can be translocated to the peripheral region of tumor tissues through the well-known enhanced permeability and retention effects.
Bond valences and anharmonicity in vacancy-ordered double perovskite halides
Authors: Maughan Annalise E. , Paecklar Arnold A. , Neilson James R.
Published: October 2018

Anharmonicity is observed in vacancy-ordered double perovskites when the A-site cation is not optimally coordinated by the octahedral framework.
Highly conductive and ultra-durable electronic textiles via covalent immobilization of carbon nanomaterials on cotton fabric
Authors: Cui Junshuo , Zhou Shuxue
Published: October 2018

Graphene and MWCNTs were firmly immobilized on the fiber surface by covalent networks generated from the condensation of the reactive dispersant.
Radiation damage effects in Ga2O3 materials and devices
Authors: Kim Jihyun , Pearton Stephen J. , Fares Chaker , Yang Jiancheng , Ren Fan , Kim Suhyun , Polyakov Alexander Y.
Published: October 2018

The strong bonding in wide bandgap semiconductors gives them an intrinsic radiation hardness.
Synthesis and characterization of novel electrochromic devices derived from redox-active polyamide–TiO2 hybrids
Authors: Pan Bo-Cheng , Chen Wei-Hao , Lee Tzong-Ming , Liou Guey-Sheng
Published: October 2018

Novel polyamides with hydroxyl groups and their hybrids have been successfully synthesized for the fabrication of novel electrochromic devices with enhanced electrochemical responsivity and stability.
Thermal and electrical wavelength tuning of Bragg reflection with ultraviolet light absorbers in polymer-stabilized cholesteric liquid crystals
Authors: Ranjkesh Amid , Yoon Tae-Hoon
Published: October 2018

A dual thermal and electrical polymer-stabilized cholesteric liquid crystal has been fabricated by using ultraviolet light absorbers. The Bragg reflection can be autonomously controlled by temperature and manually by an electric field.
Crystal facet engineering induced anisotropic transport of charge carriers in a perovskite
Authors: Yang Hewei , Zhou Yunzhan , Yang Yijun , Yi Ding , Ye Tao , Lam Tran Dai , Golberg Dmitri , Bao Bate , Yao Jiannian , Wang Xi
Published: October 2018

Precise control of crystal orientations and macroscopic morphology of a perovskite crystal is crucial for various optoelectronic applications relying on charge carrier transport tuning along exposed crystal facets.
DDX3 directly facilitates IKKα activation and regulates downstream signalling pathways
Authors: Fullam Anthony , Gu Lili , Höhn Yvette , Schröder Martina
Published: October 2018

DDX3 is a DEAD-box RNA helicase that we and others have previously implicated in antiviral immune signalling pathways leading to type I interferon (IFN) induction. We previously demonstrated that it directly interacts with the kinase IKKε (IκB kinase ε), enhances it activation, and then facilitates phosphorylation of the transcription factor IRF3 by IKKε. However, the TLR7/9 (Toll-like receptor 7/9)-mediated pathway, one of the most physiologically relevant IFN induction pathways, proceeds independently of IKKε or the related kinase TBK1 (TANK-binding kinase 1). This pathway induces type I IFN production via the kinases NIK (NF-κB-inducing kinase) and IKKα and is activated when plasmacytoid dendritic cells sense viral nucleic acids. In the present study, we demonstrate that DDX3 also directly interacts with IKKα and enhances its autophosphorylation and -activation. Modulation of DDX3 expression consequently affected NIK/IKKα-mediated IRF7 phosphorylation and induction of type I interferons. In addition, alternative NF-κB (nuclear factor-κB) activation, another pathway regulated by NIK and IKKα, was also down-regulated in DDX3 knockdown cells. This substantially broadens the effects of DDX3 in innate immune signalling to pathways beyond TBK1/IKKε and IFN induction. Dysregulation of these pathways is involved in disease states, and thus, our research might implicate DDX3 as a potential target for their therapeutic manipulation.
Exosomal KLF3-AS1 from hMSCs promoted cartilage repair and chondrocyte proliferation in osteoarthritis
Authors: Liu Yubao , Zou Rui , Wang Zhen , Wen Chuanyang , Zhang Fan , Lin Fuqing
Published: October 2018

The present study was designed to explore whether exosomal lncRNA-KLF3-AS1 derived from human mesenchymal stem cells (hMSCs) can serve as a positive treatment for osteoarthritis (OA). hMSCs and MSC-derived exosomes (MSC-exo) were prepared for morphological observation and identification by transmission electron microscopy and flow cytometry. IL-1β-induced OA chondrocytes and collagenase-induced rat model of OA were established for the further experiments. Lentivirus-mediated siRNA targeting KLF3-AS1 was transfected into MSCs for silencing KLF3-AS1. The real-time quantitative PCR and western blotting analysis were performed to examine the mRNA and protein levels of type II collagen alpha 1 (Col2a1), aggrecan, matrix metalloproteinase 13 and runt-related transcription factor 2. Cell proliferation, apoptosis and migration were evaluated by CCK-8 assay, flow cytometry and transwell assay. HE (hematoxylin and eosin) staining and immunohistochemistry were used for histopathological studies. MSC-exo ameliorated IL-1β-induced cartilage injury. Furthermore, lncRNA KLF3-AS1 was markedly enriched in MSC-exo, and exosomal KLF3-AS1 suppressed IL-1β-induced apoptosis of chondrocytes. Further in vivo investigation indicated that exosomal KLF3-AS1 promoted cartilage repair in a rat model of OA. Exosomal KLF3-AS1 promoted cartilage repair and chondrocyte proliferation in a rat model of OA, which might be an underlying therapeutic target for OA.
Advances in metabolic flux analysis toward genome-scale profiling of higher organisms
Authors: Basler Georg , Fernie Alisdair R. , Nikoloski Zoran
Published: October 2018

Methodological and technological advances have recently paved the way for metabolic flux profiling in higher organisms, like plants. However, in comparison with omics technologies, flux profiling has yet to provide comprehensive differential flux maps at a genome-scale and in different cell types, tissues, and organs. Here we highlight the recent advances in technologies to gather metabolic labeling patterns and flux profiling approaches. We provide an opinion of how recent local flux profiling approaches can be used in conjunction with the constraint-based modeling framework to arrive at genome-scale flux maps. In addition, we point at approaches which use metabolomics data without introduction of label to predict either non-steady state fluxes in a time-series experiment or flux changes in different experimental scenarios. The combination of these developments allows an experimentally feasible approach for flux-based large-scale systems biology studies.
Mast cell deficiency in mice results in biomass overgrowth and delayed expulsion of the rat tapeworm Hymenolepis diminuta
Authors: González Marisol I. , Lopes Fernando , McKay Derek M. , Reyes José L.
Published: October 2018

Infection with helminth parasites evokes a complex cellular response in the host, where granulocytes (i.e. eosinophils, basophils and mast cells (MCs)) feature prominently. In addition to being used as markers of helminthic infections, MCs have been implicated in worm expulsion since animals defective in c-kit signaling, which results in diminished MC numbers, can have delayed worm expulsion. The role of MCs in the rejection of the rat tapeworm, Hymenolepsis diminuta, from the non-permissive mouse host is not known. MC-deficient mice display a delay in the expulsion of H. diminuta that is accompanied by a less intense splenic Th2 response, as determined by in vitro release of interleukin (IL)-4, IL-5 and IL-13 cytokines. Moreover, worms retrieved from MC-deficient mice were larger than those from wild-type (WT) mice. Assessment of gut-derived IL-25, IL-33, thymic stromal lymphopoietin revealed lower levels in uninfected MC-deficient mice compared with WT, suggesting a role for MCs in homeostatic control of these cytokines: differences in these gut cytokines between the mouse strains were not observed after infection with H. diminuta. Finally, mice infected with H. diminuta display less severe dinitrobenzene sulphonic acid (DNBS)-induced colitis, and this beneficial effect of the worm was unaltered in MC-deficient mice challenged with DNBS, as assessed by a macroscopic disease score. Thus, while MCs are not essential for rejection of H. diminuta from mice, their absence slows the kinetics of expulsion allowing the development of greater worm biomass prior to successful rejection of the parasitic burden.
The association between rs16917496 T/C polymorphism ofSET8gene and cancer risk in Asian populations: a meta-analysis
Authors: Wei Hui-Xia , Tian Guo-Xiang , Song Ju-Kun , Yang Lian-Jie , Wang Yu-Pei
Published: October 2018

Epidemiological studies have demonstrated close associations between SET8 rs16917496 T/C polymorphism and cancer risk, but the results of published studies were not consistent. We therefore performed this meta-analysis to explore the associations between rs16917496 T/C polymorphism and cancer risk. Five online databases were searched. Odds ratios (ORs) with a 95% confidence interval (CI) were calculated to assess the association between rs16917496 T/C polymorphism and cancer risk. In addition, heterogeneity, accumulative, sensitivity analysis, and publication bias were conducted to check the statistical power. Overall, 13 publications involving 5878 subjects were identified according to included criteria. No significant cancer risk was observed in genetic model of SET8 rs16917496 T/C polymorphism in Asian populations (C vs. T: OR = 1.04, 95%CI = 0.88–1.23, P = 0.63%; TC vs. TT: OR = 1.17, 95%CI = 0.96–1.24, P = 0.11%; CC vs. TT: OR = 0.90, 95%CI = 0.60–1.37, P = 0.63; TC+CC vs. TT: OR = 1.11, 95%CI = 0.90–1.38, P = 0.33; CC vs. TT+TC: OR = 0.92, 95%CI = 0.65–1.30, P = 0.63). Furthermore, similar associations were found in the subgroup analysis of race diversity, control design, genotyping methods, and different cancer types. In summary, our meta-analysis indicated that the SET8 rs16917496 T/C polymorphism may not play a critical role in cancer development in Asian populations.
Prognostic values of F-box members in breast cancer: an online database analysis and literature review
Authors: Wang Xiaochen , Zhang Tao , Zhang Shizhen , Shan Jinlan
Published: October 2018

Introduction: F-box proteins are the substrate-recognizing subunits of SKP1 (S-phase kinase-associated protein 1)–cullin1–F-box protein (SCF) E3 ligase complexes that play pivotal roles in multiple cellular processes, including cell proliferation, apoptosis, angiogenesis, invasion, and metastasis. Dysregulation of F-box proteins may lead to an unbalanced proteolysis of numerous protein substrates, contributing to progression of human malignancies. However, the prognostic values of F-box members, especially at mRNA levels, in breast cancer (BC) are elusive. Methods: An online database, which is constructed based on the gene expression data and survival information downloaded from GEO (http://www.ncbi.nlm.nih.gov/geo/), was used to investigate the prognostic values of 15 members of F-box mRNA expression in BC. Results: We found that higher mRNA expression levels of FBXO1, FBXO31, SKP2, and FBXO5 were significantly associated with worse prognosis for BC patients. While FBXO4 and β-TrCP1 were found to be correlated to better overall survival (OS). Conclusion: The associated results provide new insights into F-box members in the development and progression of BC. Further researches to explore the F-box protein-targetting reagents for treating BC are needed.
Higher Ki67 expression in fibroblast like cells at invasive front indicates better clinical outcomes in oral squamous cell carcinoma patients
Authors: Jing Yue , Yang Yan , Hao Fengyao , Song Yuxian , Zhang Xiaoxin , Zhang Ye , Huang Xiaofeng , Hu Qingang , Ni Yanhong
Published: October 2018

Background: Ki67 has been a key role for the treatment options and prognosis evaluation in some kinds of tumors; however, the spatial expression of Ki67 in oral squamous cell carcinoma (OSCC) has not been fully-evaluated. Therefore, in the present study, we aimed to elucidate the prognosis value of Ki67 spatial expression including in different cell types and at different compartments of tumor in OSCC patients. Methods: Immunohistochemical expression of Ki67 in tumor cells (TCs) and fibroblast like cells (FLCs) at center of tumor (CT) and invasive front (IF) was evaluated in 109 OSCC patients. Then correlations of Ki67 expressions with clinicopathological parameters were analyzed by Chi-square test, and survival curves were evaluated by Kaplan–Meier methods. Furthermore, univariate and multivariate analysis were performed to assess the diagnostic values of Ki67 expression by the Cox regression model. Results: Ki67 expression in TCs was much higher than in FLCs both at CT and IF compartments, but Ki67 expression in TCs was simultaneously higher at CT than that at IF (P=0.0004), which was converse to Ki67 expression in FLCs (P<0.0001). Additionally, high Ki67 expression in FLCs at IF was significantly associated with poor tumor differentiation (P=0.003), worse depth of invasion (DOI, P=0.027) and worst pattern of invasion (WPOI, P=0.041), but Ki67 expression in TCs had no correlation with clinical parameters no matter at CT or IF. Moreover, patients with higher Ki67 expression in TCs at CT had significantly increased risk for OS (overall survival; HR:1.935, 95% CI: 1.181–4.823, P=0.0395) and DFS (disease-free survival; HR: 2.974, 95% CI:1.189–5.023, P=0.046). On contrary, higher Ki67 expression in FLCs at IF was correlated with better OS (HR: 0.15, 95% CI: 0.018–0.846, P=0.0396) and DFS (HR: 0.15, 95% CI: 0.018–0.947, P=0.0445). Whereas, Ki67 expression both at TCs in IF and at FLCs in CT had no significant prognostic value for OS and DFS. Furthermore, Cox multivariate analysis revealed that Ki67 expression in FLCs at IF could not be an independent prognostic factor for OSCC patients. Conclusion: These results show that higher Ki67 expression in FLCs at IF indicated better clinical outcomes for OSCC patients.
Integrable all‐optical pass switch
Authors: Datta T. , Sen M.
Published: October 2018

A completely new design for an all‐silicon all‐optical pass switch has been proposed based on the stimulated Raman scattering (SRS) in silicon nanocrystal embedded slotted photonic crystal waveguide (SPCW). Substantial miniaturisation in the device footprint and operating power has been attained by merging the benefits of the giant SRS gain and the ultra‐high optical confinement of the SPCW. The proposed switch offers a tremendously high contrast ratio of between the logic levels and an extraordinary bit rate of 125 Gbps.
Intentional islanding method based on community detection for distribution networks
Authors: Zhang Haiyan , Peng Minfang , Palensky Peter
Published: October 2018

Complex network theory is introduced to solve the islanding problem in an emergency of distribution networks. In this study, the authors put forward an intentional islanding method based on community detection. In this method, a new index has been defined called electrical edge betweenness, on the strength of edge betweenness in complex networks, which fuses electrical characteristics with topological features of actual power lines. Based on the index, the Girvan–Newman algorithm is employed to detect the community structure of distribution networks. Through referring to the modularity value (function Q) and coherent generator groups, they can get a reasonable amount and regions of communities. Then the whole distribution network can be partitioned into several self‐sustainable islands meeting the stable operation constraints. The effectiveness of the authors’ proposed method is tested on a standard IEEE 118‐bus system.
Adaptive protection methodology in microgrid for fault location and nature detection using q0 components of fault current
Authors: Singh Manjeet , Basak Prasenjit
Published: October 2018

The dynamic behaviour of microgrid system under faulty conditions makes adaptive protection a general necessity for reliable microgrid operation. In design of adaptive protection, the grid‐connected and islanded modes have immense importance including grid‐connected mode without distributed generators (DGs) in microgrid. In this study, a new adaptive protection scheme is proposed based on the above‐mentioned modes of microgrid operation. The proposed method considers nature of DGs connected, fault location detection and fault nature identification based on quadrature and zero sequence components of fault current considering impact of X/R ratio of DGs. The proposed methodologies for adaptive protection schemes are verified in Matlab‐Simulink environment and the results are found to be satisfactory while various faults are simulated at different nodes of the microgrid model. At the time of verification of effectiveness of the proposed methodologies, the time derivative of quadrature and zero‐axis components of fault current are considered sufficient to instantaneously detect the fault location and fault nature in microgrid system.
Effects of coupling and overspeeding on performance of predictor antenna systems in wireless moving relays
Authors: Jamaly Nima , Svensson Tommy , Derneryd Anders
Published: October 2018

Using predictor antenna systems for modern wireless moving relays and base stations on top of vehicles such as buses, trains etc. proves to be a reliable approach for collecting channel state information to such fast moving nodes. Recently, it has been shown that coupling between different ports of a multiport antenna system used as a part of a predictor system can reduce the prediction performance. In this study, by integrating position and velocity vectors in the channel covariance matrix as seen at the antenna ports in a rich multipath environment, the authors quantify the impact of antenna coupling on prediction performance. Moreover, practically these predictor systems are designed for a certain target velocity. They further quantify the adverse effect of velocities, different from the target velocity, on prediction performance. In case open‐circuit decoupling is necessary, the sensitivity of the predictor antenna system performance with respect to the accuracy of the input network parameters is disclosed.
Lattice dynamics and phonon characteristics of complex perovskite microwave ceramics
Authors: Shi Feng , Dong He‐Lei , Zhou Di , Wang Chun‐Hai , Tan Qiu‐Lin , Xiong Ji‐Jun , Wang Qing
Published: October 2018

Complex perovskite microwave dielectric ceramics (MWDCs) of ‐type (A  = Ba, Sr,…; B ′ = Mg, Zn,…; B ″ = Nb, Ta), which exhibit excellent dielectric properties, have currently been widely used in microwave and millimetre wave devices. Vibrational spectra, including both Raman and far‐infrared (FIR) spectra, are powerful tools to investigate the atomic thermal vibrational properties of MWDCs and reveal the intrinsic origin of dielectric properties. In this review, lattice dynamics and phonon characteristics of the ‐type MWDCs are summarised and presented in detail to introduce remarkable progress in this field and make a guide for the design of novel advanced MWDCs. The atomic sites and the corresponding modes in Raman and FIR spectra are identified and illuminated. The effects of the processing conditions and the ordered superstructures in the nanoscale region on vibrational modes are summarised systemically. Intrinsic properties can be extrapolated from the fitting results of FIR spectroscopy, which were also discussed based on the Kramers–Krönig relations, Lorentz three‐parameter classical model and four‐parameter semi‐quantum model. The correlations between vibrational modes (phonons), crystal structures, and dielectric properties are created, which can help to build the mathematical models so as to understand the structure–property relationship of MWDCs better.
Thermodynamic processes on a semiconductor surface during in‐situ multi‐beam laser interference patterning
Authors: Wang Yun‐Ran , Jin Chao‐Yuan , Ho Chih‐Hua , Chen Si , Francis Henry , Hopkinson Mark
Published: October 2018

Laser interference has been widely used to produce one‐dimensional gratings and more recently has shown great potential for two‐dimensional patterning. In this study, the authors examine by simulation, its application to in‐situ patterning during materials growth. To understand the potential, it is important to study the surface processes resulting from the laser–matter interaction, which have a key influence on the resulting growth mechanisms. In this work, the intensity distribution and the laser–semiconductor interaction resulting from four‐beam interference patterns are analysed by numerical simulations. In particular, the authors derive the time and spatially dependent thermal distribution along with the thermal‐induced desorption and surface diffusion. The results provide a crucial understanding of the light‐induced thermal profile and show that the surface temperature and the surface adatom kinetics can be controlled by multi‐beam pulsed laser interference patterning due to photothermal reactions. The approach has potential as an in‐situ technique for the fast and precise nanostructuring of semiconductor material surfaces.