bluuebunny/crossref_metadata_2025 huggingface dataset:
TRANSTORNO DO ESPECTRO AUTISTA E COMO A ALIMENTAÇÃO PODE INFLUENCIAR NA QUALIDADE DE VIDA
Authors: Brasil Frauches Novaes Estela , Ferreira da Silva Juliana
Published: November 2024

Resumo: Objetivo: Avaliar a influência da alimentação na vida de pessoas com Transtorno do Espectro Autista (TEA). Método: Trata-se de pesquisa de abordagem quantitativa e transversal, do tipo exploratória e descritiva, realizada com 134 participantes, dentre eles, pessoas com TEA ou responsável por alguma pessoa enquadrada no TEA, de diversas áreas do país, por meio de um questionário misto, com uso da análise de dados, identificando o perfil sociodemográfico, o grau de dependência e/ou necessidade de suporte (autismo leve, moderado ou severo) e os hábitos alimentares de cada indivíduo. Resultados: Os dados coletados indicam que algumas mudanças na alimentação podem trazer benefícios a essas pessoas, como resolução dos problemas gastrointestinais, melhora do sono, melhora na concentração, diminuição das estereotipias motoras e verbais, diminuição do comportamento autoagressivo, melhora na linguagem verbal e não verbal, impulso positivo na afetividade e melhora no contato ocular. Conclusão: A maioria dos entrevistados nunca experimentou fazer mudanças alimentares, o que reflete uma falta de conhecimento da população acerca dos benefícios que uma alimentação adequada a cada situação pode trazer, assim como os prejuízos que o consumo de determinados alimentos pode acarretar na vida de pessoas com TEA, tendo em vista, ser muito comum a sensibilidade alimentar, que pode incluir alergias alimentares, intolerâncias e sensibilidades ao glúten ou à lactose, por exemplo.
TOXINA BOTULÍNICA: SEU USO NA ODONTOLOGIA
Authors: Araújo Lavínya Maria Silva de , Vasconcelos Maria Eduarda Darigo , Borba Maria Tereza Lopes de Moura , Silva Vanielle Thaís Gomes da , Borja Alessandra Catarina Domingos Menezes de , Araújo Adrielly Oliveira Soares de , Correia Moana Catarina de Lima , Oliveira Danielen Camilly de , Silva Jefferson Henrique dos Santos , Bezerra Agna Roberta Xavier , Souza Williane Félix Dias de , Santana Vitória Augusta Martins de Andrade
Published: November 2024

Introdução: A toxina botulínica é estudada desde a descoberta do Botulismo, doença neuroparalítica causada pela Clostridium botulinum. Atualmente, essa bactéria serve para fins terapêuticos, tendo como função paralisar o local em que foi injetada. Tem se evidenciado na área odontológica, mostrando eficiência em casos como: implantes dentários, hipertrofia do masseter, bruxismo e espasmos mandibulares. Ademais, os pacientes vêm buscando rejuvenescimento 1. Objetivo: Promover um estudo aprofundado da relação da toxina botulínica com a odontologia, assim como suas diversas formas de aplicação e utilização na área.  Metodologia: O trabalho em questão refere-se a uma revisão integrativa, realizada por meio da pesquisa de artigos para a leitura, nas línguas português, inglês e espanhol durante os meses de janeiro à abril de 2024, através da utilização de bases de dados como PubMed, Scielo e PMC. Resultados: Foi encontrada a seguinte quantidade de artigos: 119 (Scielo); 101 (PubMed); 30 (Science Direct) apenas com a aplicação do filtro do lapso temporal. Conclusão: Logo, destaca-se a relevância da Toxina Botulínica para os dentistas, visto que estes têm propriedade para atuar no ramo terapêutico e estético.
MORTALIDADE DE PACIENTES COM DIABETES MELLITUS NA REGIÃO NORTE
Authors: Barbieri Costa Janice , Rocha Diniz Virgínio Renan , de Matos Yamada João Victor , Antão dos Santos Priscila , Paiva dos Santos Wanderson , Serralva Bonneterre Vitória , Costa Freitas Alves Darci Rosane , Damasceno Costa Maíra , Alencar de Melo Leandra Rafaela , Benítez Córdoba Claudia Vanessa , Martinez Salazar Victor Alfonso , Abinadab Majjul Salazar Eduardo , Martinez Salazar Gustavo Adolfo , Silveira Avelar Giovana , Janeo da Silva Gomes Severiano
Published: November 2024

A mortalidade por Diabetes Mellitus representa um desafio de saúde pública global, em razão das complicações associadas. Objetivo: analisar o perfil da mortalidade por Diabetes Mellitus na Região Norte, no período de 2018 a 2022. Método: Trata-se de um estudo ecológico descritivo, de séries temporais, utilizando dados secundários obtidos no Departamento de Informática do SUS (DATASUS), com os seguintes variaveis, ano de ocorrencia,sexo e faixa etaria no recorte temporal de 2018 a 2022 especificamente na região norte. Observou-se que na  região Norte, uma predominância entre os os anos de  2021 (5.262) e 2022 (4.951). Em relação às faixas etárias analisadas destaca-se entre  70 a 79 anos com um número de 7.111 casos, em seguida a faixa etária de 60 a 69 anos com 6.424 com segundo maior número de óbitos por diabetes mellitus na região norte do país. Dessa forma, o sexo feminino tem uma maior prevalência  com 13.146 óbitos de DM. Com isso, torna-se fundamental implementar estratégias mais eficazes de prevenção e manejo para reduzir a mortes por  diabetes mellitus. É essencial investir em programas de educação em saúde e ampliar o acesso a cuidados preventivos.
"دور عمليات المعرفة في تطوير الخدمات الصحية"
Authors:   باحثة دكتوراه في جامعة الملك عبد العزيز، برنامج إدارة المعرفة محاضرة في جامعة الملك عبد العزيز, السلمي ابرار فالح
Published: November 2024

هدف البحث الحالي إلى مراجعة أدب الموضوع المتعلق بعمليات إدارة المعرفة و دورها في تطوير الخدمات الصحية، ولتحقيق ذلك تم البحث في الإنتاج العلمي و الأدب ذو الصلة و اختيار الكلمات الأساسية و قواعد البيانات المناسبة.و البحث عن ملخصات ذات الصلة المنشورة والمتاحة للاطلاع و كذلك البحث في المنشورات باللغات العربية والأجنبية و الأبحاث المنشورة خلال السنوات الثمانية عشر الأخيرة من عام (2006-2023).
Uncontrolled Cholesterol in Individuals with Severe Hypercholesterolemia in a Health Evaluation Program in Brazil
Authors: Santos Raul D. , Kashiwagi Nea Miwa , Cesena Fernando Yue , Assis Silvia Regina Lamas , Nieri Josué , Minanni Carlos Andre , Franken Marcelo , Berwanger Otavio
Published: November 2024

Abstract Background Individuals with severe hypercholesterolemia (SH) are considered at high atherosclerosis risk and should be intensively treated with lipid-lowering drugs aiming for an LDL-C reduction of≥50% and a goal of <70 mg/dL. Objectives This study aimed to evaluate cholesterol control in individuals with SH (LDL-C ≥ 190 mg/dL or 160-189 mg/dL using lipid-lowering drugs) followed in a health evaluation program. Methods 55,000 individuals were evaluated, of which 2,214 (4%) had SH, and 1,016 (45.8%) had repeated assessments. Achievement of recommended LDL-C goals was the primary study endpoint. A p-value < 0.05 was considered significant. Results Mean age (± SD) was 44.9±8.8 years, 84.2% were men, and 0.5% reported previous myocardial infarction. Mean LDL-C was 203.0±22.0 mg/dL, and although 62.5% referred dyslipidemia, only 19% were using lipid-lowering drugs (5.9% in cases with LDL-C ≥ 190 mg/dL). During a 4.1±2.8-year follow-up, use of lipid-lowering drugs increased from 18.1% to 48.4% (p<0.00001), 5.9% to 45.4% in those with LDL-C ≥ 190 mg/dL (p< 0.00001) though 31% of cases with LDL-C 160-189 mg/dL stopped taking medications. Overall, there was a mean 26.7% reduction in LDL-C (p<0.0001), and LDL-C reductions ≥50% were attained in 19.2%, 19.1%, and 19.7 % of all individuals, and in those with LDL-C > 190 mg/dL and 160-189 mg/dL respectively. Only 3.1% reached LDL-C < 70 mg/dL (2.7% in those with LDL-C ≥ 190 and 5.3% in those with 160-189 mg/dL). Conclusions A serious gap was found between treatment recommendations and reality in individuals at high atherosclerosis risk due to SH.
Osteoprotegerina e Disfunção Vascular em Pacientes com Doença Renal Crônica Estágio 3 e em Pacientes sem Disfunção Renal: Estudo Caso-Controle
Authors: Matos Thalita de Oliveira , Vitorino Priscila Valverde de Oliveira , Orlow Rogerio , Melo Átila de Oliveira , Amorim Diogo da Silva , Sousa Gleidson Junio Oliveira , Jorgetti Vanda , Sousa Ana Luiza Lima , Bezerra Rodrigo , Barroso Weimar Kunz Sebba
Published: November 2024

Resumo Fundamento A osteoprotegerina (OPG) é um marcador de calcificação vascular e de risco cardiovascular em pacientes com doença renal crônica (DRC). Objetivos Comparar e correlacionar os valores de OPG com as medidas de dilatação fluxo-mediada (DFM) e de velocidade de onda de pulso (VOP) em pacientes com DRC estágio 3 e em indivíduos sem disfunção renal. Métodos Este estudo caso-controle foi conduzido em um centro especializado em hipertensão em 2022. Um total de 79 pacientes com idade acima de 18 anos participou do estudo. O grupo caso foi composto de 30 pacientes com disfunção renal moderada (DRC estágio 3) e o grupo controle incluiu 49 indivíduos com uma taxa de filtração ≥ 60 mL/min/1,73 m2. O nível de significância adotado na análise estatística foi de 5%. Resultados A pressão de pulso central (PPC), a VOP e o índice de aumento (IA) foram mais altos nos pacientes com disfunção renal. Os níveis séricos de OPG mostraram uma correlação positiva com a pressão arterial sistólica central e periférica, PPC, VOP e IA. Por outro lado, valores séricos de OPG não se correlacionaram com DFM. Conclusões A OPG e a VOP são possíveis biomarcadores de disfunção vascular que se encontram alterados em pacientes com disfunção renal moderada. Apesar de limitações deste estudo, incluindo o fato de ser um estudo caso-controle conduzido em um único centro, o estudo tem o potencial, como uma prova de conceito, de gerar a hipótese de que tanto a OPG como a VOP são biomarcadores de dano vascular precoce nessa população.
ПРИМЕНЕНИЕ КОУЧИНГ-ТЕХНОЛОГИЙ В РАЗВИТИИ
ТРУДОВОГО ПОТЕНЦИАЛА ПРЕДПРИЯТИЯ
Authors: Дадаев Я.Э.
Published: November 2024

Статья посвящена исследованию коучинг-технологий в системе развития трудового потенциала предприятия, их значения для эффективной реализации и повышения производительности труда персонала предприятия. Рассмотрена сущность коучинга, его функции, последствия применения различных видов коучинга в деятельности предприятия. Доказано, что применение коучинг-технологий является эффективным инструментом повышения эффективности использования человеческого ресурса предприятия посредством раскрытия его потенциала. Установлено, что использование технологий коучинга в развитии трудового потенциала предприятия имеет не только экономический, но и социальный эффект.
ВЛИЯНИЕ ЦИФРОВИЗАЦИИ НА КВАЛИФИКАЦИЮ
И ГИБКОСТЬ РАБОЧЕЙ СИЛЫ
Authors: Идигова Л.М. , Истамилов И.С.
Published: November 2024

Статья посвящена описанию рынка труда в условиях перехода общества в информационную эпоху. Рассмотрено применение различных технологий и улучшение социально-экономического развития за счёт их внедрения. Раскрыто содержание трактовки понятия «цифровизация», определены виды цифровых технологий, влияющие на квалификацию и гибкость рабочей силы, проанализированы количественные показатели, отражающие динамику изменения этих двух категорий, рассмотрены зарубежный и российский рынок труда, рассмотрены тенденции появления новых цифровых навыков и развития форм труда. Авторами в результате анализа сделан вывод, что количество рабочей силы, занятой удаленно, в России увеличивается в связи с универсальностью применения цифровых технологий во всех экономических отраслях, количество специалистов в интернет-профессиях, работающих удаленно, увеличивается. По мнению авторов цифровизация даёт большие возможности для получения навыков, удобного формата работы и эффективной коммуникации.
Observaciones sobre la fórmula in hono. Argael. en un epígrafe de Cacabelos, León (CIL II 5672)
Authors: González Rodríguez Mª Cruz , Ramírez Sánchez Manuel
Published: November 2024

Some reflections are given about the inscription dedicated to dea Degant. (CIL II 5672), discovered in Cacabelos (León) at the end of the 19th century. From the epigraphical analysis, this paper focuses on the relations with other religious dedications from the Roman Empire that includes in honorem formula. If our hypothesis is correct, the goddess Deganta would be the protective divinity of the cognatio Argael(orum), as the Lares Lubancos are the protectors of the Douilinic(orum) horum mentioned in an inscription from Conimbriga.
Dos nuevos grafitos celtibéricos procedentes de Burzau (Borja, Zaragoza)
Authors: Aguilera Aragón Isidro , Jordán Cólera Carlos
Published: November 2024

The paper provides two new celtiberian graffiti from Burzau(Borja, Zaragoza).
Esgrafiado en signario paleohispánico hallado en Pamplona
Authors: García-Barberena María , Unzu Mercedes , Velaza Frías Javier
Published: November 2024

In this paper we present a Palaeohispanic inscription on pottery found in Pamplona and we analyse the writing system and the language in which it is written.
Un doble sello sobre cerámica indígena de época altoimperial hallado en Dessobriga (Osorno, Palencia / Melgar, Burgos)
Authors: Torrione Margarita , De Hoz Bravo Javier , Fernández Ibáñez Carmelo
Published: November 2024

An unpublished, at first view epigraphic, double stamp on Early Roman Empire Vaccean pottery found at the archaeological site of Dessobriga (Osorno la Mayor, Palencia / Melgar de Fernamental, Burgos), in course of excavation since 2014. Context of the find, epigraphic study and restoration process.
Lenguas anindoeuropeas de Hispania ¿antiguas o recientes?
Authors: Ballester Xaverio
Published: November 2024

According to the data presented here, the historic non-Indo-European languages of Spain, Iberian and Aquitanian —ie., old Basque— would not be pre-Indo-European relicts, as traditionally assumed, but the results of intrusive newcomers that entered the Iberian Peninsula in relatively recent times.
La relación de las competencias investigativas, digitales e informacionales en estudiantes normalistas
Authors: Pérez López Kenia Heribett , Soto Decuir María Guadalupe , Zaldívar-Colado Aníbal , Mazo Sandoval Isabel Cristina
Published: November 2024

The purpose of the research was to determine if there is a relationship between investigative skills and the development of digital and informational skills in normal school students from Sinaloa, within the framework of their training process. From a quantitative approach, a non-experimental, transectional and descriptive-correlational design was used; a questionnaire was applied as a data collection instrument to a sample of 154 students who were studying the eighth semester of the bachelor’s degree in Primary Education. The results are aimed at analyzing the categories of investigative, digital and informational competencies. Each of them is detailed and the skills acquired by the study subjects are emphasized, which were developed in accordance with the guidelines and demands of the teachers. The conclusions focus on areas of opportunity for further research. As it is an activity that is carried out superficially, students acquire few research skills, which invites us to reflect on the role of the teacher in the training of future teachers and the need to reformulate research work as an opportunity to contribute to the educational process of young people with disabilities. analytical and critical sense, who will be the next trainers of boys and girls.
Predicting the Performance of Vietnamese Sugar Mills: An Application of the Grey Verhulst Model
Authors: Ho Nguyen-Nhu-Y , Nguyen Phuong Mai , Le Huong Linh , Nguyen Huu Khanh
Published: November 2024

The sugar industry plays a critical role in the Vietnamese economy, contributing to annual economic growth and job creation. However, the performance of Vietnamese sugar mills has been recognized to be under potential and seems to decline in recent years due to changes in the internal and external environments. Thus, it is necessary to evaluate and predict the performance of companies in this industry to find solutions for their long-run growth. In such a context, this paper aims to predict the performance of Vietnamese sugar mills so that they can improve their profitability for sustainable development in the future. We employed the Grey Verhulst model to analyze data from 16 Vietnamese sugar mills in the 2020–2023 period. The data collected include key financial indicators, such as total assets, cost of goods sold, selling and distribution costs, net profit, and inventory. Firstly, we proved that our proposed forecast model is applicable for the Vietnamese sugar industry with high percentage of reliability and accuracy. Then, using the model, we have predicted the performance of these firms for the period of 2024–2027. Our prediction shows that sugar mills grapple with familiar industry challenges as consumption declines. It is predicted that net profit criteria have the tendency to decline This slowdown places them under significant competitive pressure from foreign sugar producers. Thus, we suggest that sugar mills use our research results to formulate their strategic plan to mitigate the potential risks and position themselves in the market for their long-term profit and sustainable development in the future.
Anteseden Yang Mempengaruhi Revisit Intention Wisatawan Di Kawasan Wisata Nusa Penida
Authors: Premayani Ni Wayan Wina
Published: November 2024

Kawasan Wisata Nusa Penida yang merupakan salah satu daya tarik wisata favorit di Kabupaten Klungkung perlu prioritas dalam mengoptimalkan realisasi pengembangan destinasi wisata demi mempertahankan tingkat kunjungan wisatawan. Penelitian ini bertujuan untuk mengetahui dan menganalisis pengaruh destination image dan self-congruity terhadap revisit intention melalui memorable tourism experience. Pengujian hipotesis penelitian menggunakan teknik analisis Structural Equation Modeling (SEM-PLS) dengan menggunakan bantuan software SMARTPLS. Sampel dalam penelitian ini berjumlah 100 responden, dipilih dengan menggunakan teknik penentuan sampel Purposive Sampling, dengan kriteria wisatawan yang pernah melakukan perjalanan wisata ke Kawasan Wisata Nusa Penida. Hasil penelitian menunjukkan bahwa destination image berpengaruh positif dan signifikan terhadap memorable tourism experience, destination image berpengaruh positif dan signifikan terhadap revisit intention, memorable tourism experience berpengaruh positif dan signifikan terhadap revisit intention, self-congruity berpengaruh positif dan signifikan terhadap memorable tourism experience, self-congruity berpengaruh positif dan signifikan terhadap revisit intention, destination image berpengaruh signifkan terhadap revisit intention melalui memorable tourism experience, serta self-congruity berpengaruh signifkan terhadap revisit intention melalui memorable tourism experience. Untuk meningkatkan minat berkunjung kembali para wisatawan ke kawasan destinasi wisata Nusa Penida maka disarankan untuk menciptakan citra destinasi yang positif dalam persepsi wisatawan, dan disaat yang bersamaan citra destinasi kawasan wisata Nusa Penida perlu memiliki kesesuaian dengan konsep diri wisatawan yang secara psikologis sangat mempengaruhi minat berkunjung kembali, selain itu dengan memberikan pengalaman berkesan yang tidak dilupakan oleh wisatawan akan menjadi kenangan yang ingin kembali diulang oleh wisatawan dengan berkunjung kembali ke kawasan destinasi wisata Nusa Penida
Structure of (σ, ρ)-n-Derivations on Rings
Authors: Ansari Abu Zaid , Shujat Faiza , Fallatah Ahlam
Published: November 2024

The goal of this research is to describe the structure of Jordan (σ, ρ)-n-derivations on a prime ring. By (σ, ρ)- n-derivations, we mean n-additive maps ℑ : Rn →R  satisfying the following property in each n-slot:
                  ℑ(pq, ϖ1, ··· , ϖn−1) = ℑ(p, ϖ1, ··· , ϖn−1)σ(q) +ρ(p)ℑ(q, ϖ1, ··· , ϖn−1),
for every p, q, ϖ1, ··· , ϖn−1∈ R. We find the conditions under which every Jordan (σ, ρ)-n-derivation becomes a (σ, ρ)-n-derivation. Moreover, the concept of ∗-n-centralizers on ∗-ring has given. The ∗-ring is also used for examining some outcomes, where left and right ∗-n-centralizers are significant
Shifting Patterns of Ocular Emergencies: A Comparative Study in Basrah, Iraq
Authors: Mokhles Jerri Meften Al-Sabti  , Khalid Tawfeeq Najm Alsayab
Published: November 2024

Introduction: Ocular emergencies present a significant public health concern, potentially leading to vision loss if not addressed promptly. Understanding the dynamics of these emergencies is essential for effective healthcare planning and resource allocation. This study aimed to analyze the trends and characteristics of ocular emergencies in Basrah, Iraq, and compare them with historical data.
Methods: A retrospective study was conducted at Al-Sayab Teaching Hospital in Basrah, involving 250 patients presenting to the ophthalmology emergency department between January 1st, 2023, and December 31st, 2023. Data regarding demographics, presentation time, causes of emergencies, and visual acuity were analyzed.
Results: The leading causes of ocular emergencies were inflammatory diseases (32%), trauma (28%), and foreign bodies (33.2%). A significant proportion of patients (20%) presented with severe visual impairment (less than 20/200). Most emergencies occurred in males (72.4%), primarily in the 20-40 year age group.
Conclusion: The study highlights a high prevalence of inflammatory diseases and trauma among ocular emergencies in Basrah. Public health interventions should focus on preventing ocular trauma and improving access to eye care services. Continuous monitoring of these patterns is crucial for effective public health planning.
Men's Perceptions of Seaweed Farming in Zanzibar, Tanzania: Exploring Gender Dynamics in Coastal Livelihoods
Authors: Ndunguru Fredy E. , Mbunda Kastory A.
Published: November 2024

Seaweed farming is emerging as a cornerstone of the blue economy, significantly boosting national GDP and creating vital economic opportunities for coastal communities. Despite its potential contribution, the sector is dominated by gender imbalance: approximately 80% of Zanzibar's 23,000 seaweed farmers are women, highlighting an underrepresentation of men in this potential sector. This study examined men’s perceptions of seaweed farming in Zanzibar, specifically focusing on the coastal wards of Jambiani, Paje, and Bwejuu. A cross-sectional research design was utilized, and data were collected through a structured questionnaire administered to a randomly selected sample of 150 men aged 18 to 55 years in the study area. Findings indicate that over 70% of men in Zanzibar have negative perceptions regarding seaweed farming. Specifically, 72% of the male respondents classified seaweed farming to be primarily a feminine activity. The binary logistic regression analysis revealed several statistically significant perceptions that substantially impact men's participation in seaweed farming. Notably, age (coef = -1.182, p = 0.000), the perception that seaweed farming is a women-based economic activity (coef = -0.358, p = 0.016) and the belief that it cannot meet household needs (coef = -0.780, p = 0.041). Furthermore, the belief that it is difficult to develop through seaweed farming (coef = -0.780, p = 0.001) and the perception that it requires costly inputs (coef = -0.181, p = 0.000) were also significant perceptions. The study highlights gender stereotypes and socio-cultural misconceptions affecting men's participation in seaweed farming in Zanzibar. To address these issues, the study recommends the implementation of gender-sensitive educational programs, workshops, and community discussions that raise awareness of seaweed's economic potential, challenge stereotypes and conduct ongoing research to monitor changes in perceptions and participation rates
Navigating Leadership and Management Challenges in the Transition to Competency-Based Curriculum in Junior Secondary Education Subtheme: Education Leadership and Management
Authors: Barasa Didmus Wekesa , Omariba Alice
Published: November 2024

The transition to a Competency-Based Curriculum (CBC) in junior secondary education represents a significant shift from traditional content-based models to approaches emphasizing practical skills and competencies. This study investigates the leadership and management challenges faced during this transition, focusing on schools in Kenya. Using a qualitative research design, including case studies, semi-structured interviews, and document analysis, the study explores the experiences of school administrators, teachers, and policymakers. Key findings reveal substantial challenges, including resistance to change, inadequate training for leaders, insufficient resources, and difficulties in aligning existing structures with CBC requirements. Additionally, the study highlights issues related to stakeholder engagement and time constraints. The findings underscore the need for comprehensive professional development programs, enhanced stakeholder involvement, and improved resource allocation to support the successful implementation of CBC. By addressing these challenges, educational leaders can better navigate the complexities of CBC and enhance the effectiveness of junior secondary education, ultimately contributing to a more adaptable and skilled workforce
Pengembangan Virtual Reality Chemistry Berbasis Kearifan Lokal Alam Kalimantan Tengah Untuk Meningkatkan Kemampuan 4C Mahasiswa
Authors: Anatasya Violina , Putra Nandito
Published: November 2024

Practicum is an effective method used in learning to improve skills and deepen chemical concepts and theories. However, the main obstacle in the chemistry practicum process is the procurement process regarding the limitations of the tools and materials needed. One innovative solution to overcome this challenge is to utilize Virtual Reality (VR) technology, which allows students to understand the material through interactive simulations. On the other hand, Central Kalimantan has a wealth of local wisdom that can be used as a means to associate chemical concepts with daily life. Through this research, a Virtual Reality Chemistry Laboratory (VRCL) was developed that integrates elements of local wisdom in Central Kalimantan. The research method used in this study is development research (R&D) with the ADDIE model, with the initial step of conducting analysis. This study aims to evaluate the extent to which VRCL can improve students' understanding of chemical concepts and strengthen the connection between science and local culture. The results of this study are expected to make an important contribution to the development of more contextual and relevant learning methods for students. The use of Virtual Reality Chemistry Laboratory combined with the local wisdom of Central Kalimantan's nature aims to improve the 4Cs (Communication, Collaboration, Critical Thinking, and Creativity) skills of students in associating technology with local wisdom values. After going through the learning process using virtual reality media  through VR headsets, students can practice the 4Cs skills in terms of focusing questions, observing, identifying assumptions, making conclusions, and determining actions.
Future trends in Food Science and Foodomics: a perspective view by the Editorial Team of Exploration of Foods and Foodomics
Authors: Ibáñez Elena , Bicchi Carlo , Capozzi Francesco , Chen Yi , Coppola Francesca , Fanali Salvatore , Ferreira Sandra R. S. , Fischer Markus , Gavahian Mohsen , Gavara Rafael , Herrero Miguel , Kontogiorgis Christos , Liu Xianhua , Mannina Luisa , Martins-Lopes Paula , Mendiola Jose Antonio , Nazzaro Filomena , Ntakoulas Dimitrios D. , Olivero-Verbel Jesus , Picó Yolanda , Proestos Charalampos , Rai Dilip K. , Rastrelli Luca , Rios Ángel , Rubert Josep , Silva Ana Sanches , Santos-Buelga Celestino , Sharifi-Rad Javad , Câmara José S. , Vaz-Moreira Ivone , Zhang Zhaowei , Cifuentes Alejandro
Published: November 2024

In this perspective article, several internationally recognized experts, members of the editorial team of this journal, discuss a selection of current hot topics identified in Food Science and Foodomics. The topics are comprised of the main areas of Food Science and Foodomics, namely, food safety, food authenticity, food processing, and food bioactivity. Logically, several of the discussed topics involve more than one of the mentioned main areas. Regarding food safety, the topics discussed are the use of analytical nanotechnology, nanometrology, nano-chromatography; the determination of organic contaminants based on MS and NMR; the impact of microplastics and nanoplastics on food or the contamination of foods with plant toxins. Regarding food authenticity, the paper discusses the role of MS, NMR, biosensors and the new trends in foodomics for food authentication. In terms of food processing, the work shows interesting perspectives on novel processing technologies, the effect of food processing on the gut microbiota or in the interaction among secondary metabolites and macromolecules; the development of active packaging, and the potential effects of introducing recycled plastics in food packaging; the new green extraction and encapsulation strategies of bioactive compounds from food by-products; and the anti-biofilm capacity of natural compounds/extracts/vegetal oils and essential oils. Food bioactivity and the relation between food and health includes the bioavailability and bioaccessibility of bioactive compounds; new trends and challenges in the interaction of nutraceuticals with biological systems; how food matrix impacts the bioaccessibility of nutrients and bioactive compounds; or the study of biodiversity, food and human health through one-health concept. We anticipate elaborations on these hot topics will promote further studies in Food Science and Foodomics.
Rock Characterization based on the Schmidt Hammer Rebound Values: A Case Study of Jawaharlal Nehru University, New Delhi, India
Authors: Sharma Dishant
Published: November 2024

The campus of Jawaharlal Nehru University New Delhi, India provides a remarkable location to employ Schmidt Hammer in the characterization of the physical strength of rocks. The present study is based on the quantification of rock hardness and the assessment of its relationship with four attributes which determine weathering and erosion rates viz., vegetation cover, elevation, slope, and stream frequency. This study also sheds light onthe interplay of rock structure and denudational agents that may have given shape to diverse geomorph features inside the university campus. Integrated fieldwork and remote geospatial techniques areutilized and thereby, the signature of exfoliation, granular disintegration, case hardening, and honeycomb weathering are observed in the study area. A negative yet weak correlation is found between rock hardness and elevation, slope, and stream frequency. On the contrary, rock hardness and vegetation cover are found to be positively correlated.
Raman Microspectrometry of Fluid Inclusions from Quartz Veins of Eastern Mahakoshal Belt, Central India
Authors: Misra PremShanker , Pandit Dinesh , Saini Pankaj
Published: November 2024

Gold mineralization occurs in the PaleoproterozoicMahakoshalSupracrustalBelt (MSB) of the Central India Tectonic Zone (CITZ). The MSB comprises metavolcanics and metasedimentary rocks, where gold mineralization is predominantly hosted by quartz veins traversing in these rocks. In the present study, Laser Raman Microspectrometry(LRM) technique is used for characterization of various types of fluid inclusion linked with gold mineralization in the eastern part of the MSB. The gold mineralization at Parsoi, Sonapahari and GurharPahar is associated with the compositionally indistinguishable fluids.Involvement of CH4 during the transportation and deposition of the ore fluid significantly favors gold mineralization. Ore fluids with with composition of H2O NaCl-CO2 -CH4 ± N2 was accountable for gold mineralization in the eastern MSB. The genetic aspects of auriferous ore fluids in the quartz veins of eastern MSB, have implications to further exploration of gold in this mineral belt.
Bidirectional relationship between gastrointestinal cancer and depression: The key is in the microbiota-gut-brain axis
Authors: Priego-Parra Bryan Adrian , Remes-Troche Jose Maria
Published: November 2024

In this Editorial, we review the recent publication in the World Journal of Gastroenterology , which explores the complex relationship between depression and gastric cancer and offers perspectives. Key topics discussed include the microbiota-gut-brain axis, dysbiosis, and the influence of microbial metabolites in homeostasis. Additionally, we address toxic stress caused by hypothalamic-pituitary-adrenal axis dysregulation, psychological assessments, and future research directions. Our Editorial aims to expand the understanding of the bidirectional relationship between depression and gastrointestinal cancer.
Prognostic value of preoperative systemic immune-inflammation index/albumin for patients with hepatocellular carcinoma undergoing curative resection
Authors: Chen Kun-Lin , Qiu Yi-Wen , Yang Ming , Wang Tao , Yang Yi , Qiu Hai-Zhou , Sun Ting , Wang Wen-Tao
Published: November 2024

BACKGROUND

Hepatocellular carcinoma (HCC) is a major factor for cancer-associated mortality globally. Although the systemic immune-inflammation index (SII) and albumin (ALB) show individual prognostic value for various cancers, their combined significance (SII/ALB) in HCC patients undergoing curative hepatectomy is still unknown. It is hypothesized that a higher SII/ALB ratio correlates with poorer outcomes with regard to overall survival (OS) and recurrence-free survival (RFS).

AIM

To investigate the effect of preoperative SII/ALB in predicting the prognosis of HCC patients undergoing hepatectomy.

METHODS

Patients who received curative surgery for HCC at a single institution between 2014 and 2019 were retrospectively analyzed. Cox proportional hazards models and Kaplan-Meier curves were utilized to estimate OS and RFS. A nomogram was created using prognostic factors determined by the least absolute shrinkage and selection operator method and analyzed using multivariate Cox regression. This nomogram was assessed internally through the calibration plots, receiver operating characteristic (ROC) analysis, decision curve analysis (DCA) and the concordance index (C-index).

RESULTS

This study enrolled 1653 HCC patients. Multivariate analyses demonstrated that SII/ALB independently predicted OS [hazard ratio (HR) = 1.22, 95%CI: 1.03-1.46, P = 0.025] and RFS (HR = 1.19, 95%CI: 1.03-1.38, P = 0.022). Age, alpha-fetoprotein, hepatitis B surface antigen, albumin-bilirubin grade, tumor diameter, portal vein tumor thrombus, tumor number, and SII/ALB were incorporated into the nomogram to predict OS. The nomogram had a C-index of 0.73 (95%CI: 0.71-0.76) and 0.71 (95%CI: 0.67-0.74) for the training and validation cohorts, respectively. The area under the ROC curve, DCA and calibration curves demonstrated high accuracy and clinical benefits.

CONCLUSION

The SII/ALB may independently predict outcomes in HCC patients who receive curative surgical treatment. In addition, the nomogram can be used in HCC treatment decision-making.
Link between pharyngeal acid reflux episodes and the effectiveness of proton pump inhibitor therapy
Authors: Chen Yen-Yang , Wang Chen-Chi , Chuang Chun-Yi , Tsou Yung-An , Peng Yen-Chun , Chang Chi-Sen , Lien Han-Chung
Published: November 2024

BACKGROUND

Diagnosing laryngopharyngeal reflux (LPR) is challenging due to overlapping symptoms. While proton pump inhibitors (PPIs) are commonly prescribed, reliable predictors of their responsiveness are unclear. Reflux monitoring technologies like dual potential of hydrogen (pH) sensors and multichannel intraluminal impedance-pH (MII-pH) could improve diagnosis. Research suggests that a composite pH parameter, defined by ≥ 2 pharyngeal acid reflux (PAR) episodes and/or excessive esophageal acid reflux (EAR), predicts PPI efficacy. The criteria for PAR episodes, a pharyngeal pH drop of ≥ 2 units to < 5 within 30 seconds during esophageal acidification, showed strong interobserver reliability. We hypothesized that PAR episodes alone might also predict PPI responsiveness.

AIM

To investigate whether PAR episodes alone predict a positive response to PPI therapy.

METHODS

Patients suspected of having LPR were prospectively recruited from otolaryngologic clinics in three Taiwanese tertiary centers. They underwent a 24-hour esophagopharyngeal pH test using either 3-pH-sensor or hypopharyngeal MII-pH catheters while off medication, followed by a 12-week esomeprazole course (40 mg twice daily). Participants were categorized into four groups based on pH results: PAR alone, EAR alone, both pH (+), and both pH (-). The primary outcome was a ≥ 50% reduction in primary laryngeal symptoms, with observers blinded to group assignments.

RESULTS

A total of 522 patients (mean age 52.3 ± 12.8 years, 54% male) were recruited. Of these, 190 (mean age 51.5 ± 12.4 years, 61% male) completed the treatment, and 89 (47%) responded to PPI therapy. Response rates were highest in the PAR alone group (73%, n = 11), followed by EAR alone (59%, n = 68), both pH (+) (56%, n = 18), and both pH (-) (33%, n = 93). Multivariate analysis adjusting for age, sex, body mass index, and endoscopic esophagitis showed that participants with PAR alone, EAR alone, and both pH (+) were 7.4-fold (P = 0.008), 4.2-fold (P = 0.0002), and 3.4-fold (P = 0.03) more likely to respond to PPI therapy, respectively, compared to the both pH (-) group. Secondary analyses using the definition of ≥ 1 PAR episode were less robust.

CONCLUSION

In the absence of proven hypopharyngeal predictors, this post-hoc analysis found that baseline ≥ 2 PAR episodes alone are linked to PPI responsiveness, suggesting the importance of hypopharyngeal reflux monitoring.
N6-methyladenosine-modified long non-coding RNA KIF9-AS1 promotes stemness and sorafenib resistance in hepatocellular carcinoma by upregulating SHOX2 expression
Authors: Yu Yong , Lu Xiang-Hong , Mu Jin-Song , Meng Jiang-Yun , Sun Jiang-Shan , Chen Hai-Xu , Yan Yang , Meng Ke
Published: November 2024

BACKGROUND

Hepatocellular carcinoma (HCC) is a prevalent and aggressive tumor. Sorafenib is the first-line treatment for patients with advanced HCC, but resistance to sorafenib has become a significant challenge in this therapy. Cancer stem cells play a crucial role in sorafenib resistance in HCC. Our previous study revealed that the long non-coding RNA (lncRNA) KIF9-AS1 is an oncogenic gene in HCC. However, the role of KIF9-AS1 in drug resistance and cancer stemness in HCC remains unclear. Herein, we aimed to investigate the function and mechanism of the lncRNA KIF9-AS1 in cancer stemness and drug resistance in HCC.

AIM

To describe the role of the lncRNA KIF9-AS1 in cancer stemness and drug resistance in HCC and elucidate the underlying mechanism.

METHODS

Tumor tissue and adjacent non-cancerous tissue samples were collected from HCC patients. Sphere formation was quantified via a tumor sphere assay. Cell viability, proliferation, and apoptosis were evaluated via Cell Counting Kit-8, flow cytometry, and colony formation assays, respectively. The interactions between the lncRNA KIF9-AS1 and its downstream targets were confirmed via RNA immunoprecipitation and coimmunoprecipitation. The tumorigenic role of KIF9-AS1 was validated in a mouse model.

RESULTS

Compared with that in normal controls, the expression of the lncRNA KIF9-AS1 was upregulated in HCC tissues. Knockdown of KIF9-AS1 inhibited stemness and attenuated sorafenib resistance in HCC cells. Mechanistically, N6-methyladenosine modification mediated by methyltransferase-like 3/insulin-like growth factor 2 mRNA-binding protein 1 stabilized and increased the expression of KIF9-AS1 . Additionally, KIF9-AS1 increased the stability and expression of short stature homeobox 2 by promoting ubiquitin-specific peptidase 1-induced deubiquitination. Furthermore, depletion of KIF9-AS1 alleviated sorafenib resistance in a xenograft mouse model of HCC.

CONCLUSION

The N6-methyladenosine-modified lncRNA KIF9-AS1 promoted stemness and sorafenib resistance in HCC by upregulating short stature homeobox 2 expression.
Advancing early diagnosis of inflammatory bowel disease: A call for enhanced efforts
Authors: He Shu-Bei , Hu Bing
Published: November 2024

The diagnosis of inflammatory bowel disease (IBD) is complicated by its nonspecific clinical presentation and the limited accuracy of existing biomarker tests, frequently resulting in significant delays from the time of symptom onset to the achievement of a definitive diagnosis. Thus, improving the early identification of IBD remains a crucial focus for gastroenterologists. Blüthner et al innovatively utilized medical data from German IBD patients to investigate risk factors contributing to these diagnostic delays. However, certain methodological limitations in the study have impacted data extraction and interpretation, underscoring the need for more comprehensive analyses to validate these findings.
Small cell lung carcinoma metastatic to the stomach: Commonly overlooked, limited treatment options
Authors: Moyana Terence N
Published: November 2024

Small cell lung carcinoma metastatic to the stomach, whether synchronous or metachronous, is a rare phenomenon accounting for < 0.5% of lung cancers. Hence it can be overlooked by clinicians resulting in delayed diagnosis. This manuscript comments on Yang et al ’s article which reported 3 such cases. The main diagnostic features are based on routine morphology comprised of small cells with hyperchromatic nuclei, scant cytoplasm, brisk mitoses and necrosis. This can be supplemented by immunohistochemistry demonstrating positivity for cytokeratin, thyroid transcription factor-1 and neuroendocrine markers as well as a high Ki-67 labelling index. Imaging modalities such as positron emission tomography/contrast computed tomography help to confirm lung origin and rule out the possibility of extra-pulmonary small cell carcinoma. The predominant mechanism of spread is most likely hematogeneous. Prognosis is generally poor since this represents stage 4 disease but survival can be improved by chemo/radiotherapy and palliative surgery in select cases. Though outcomes have not changed much in the last several decades, the recent Food and Drug Administration approval of immune checkpoint inhibitors was a significant milestone as was the delineation of small cell lung carcinoma molecular subtypes. Liquid biopsies are increasingly being used for biomarker studies in clinical trials to assess treatment response and prognosis.
GLP-1, GIP/GLP-1, and GCGR/GLP-1 receptor agonists: Novel therapeutic agents for metabolic dysfunction-associated steatohepatitis
Authors: Singh Anmol , Sohal Aalam , Batta Akash
Published: November 2024

The global prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD) is estimated at 32.4%, reflecting its growing clinical significance. MASLD, which includes MASLD and metabolic dysfunction-associated steatohepatitis (MASH) has been linked to increased metabolic, cardiovascular, and malignant morbidity. Progression into fibrotic stages of MASLD is also strongly associated with liver-related mortality. The past few years have seen a heightened focus on creating innovative therapeutic strategies for MASH management. GLP-1 receptor agonists (RA) have also emerged as a potential treatment option. Studies on GLP-1 agonists, such as liraglutide and semaglutide, have demonstrated efficacy in MASH management, albeit with limited histological improvement of fibrosis. However, recent investigations into GLP-1/GIP RA (tirzepatide) and Glucagon/GLP-1 RA (survodutide) have shown even more encouraging results, with higher rates of MASH resolution and fibrosis improvement. The tolerability of these medications due to their gastrointestinal side effects remains a major concern. Future research should focus on optimizing drug regimens, identifying patients most likely to benefit, and balancing efficacy with tolerability. The evolving landscape of MASH therapeutics suggests a bright future, with the potential for combination therapies to further enhance patient outcomes.
Calculus bovis hijacks the tumor microenvironment in liver cancer cells in a multifaceted approach: A falling row of dominoes
Authors: Farhat Said G , Karam Karam
Published: November 2024

Calculus bovis (C . bovis ) is widely used in traditional Chinese medicine due to its anti-tumor effects. C . bovis shifts liver cancer tumor microenvironment towards regression by hindering tumor-associated macrophages polarization. Huang et al have demonstrated in their study that C . bovis inhibits M2-tumour-associated macrophages (TAM) polarization by halting the Wnt/β-catenin pathway. The mechanism of action by which C . bovis exerts its anti-tumor effects is multifaceted and includes network pharmacology, transcriptomics and molecular docking. In vitro assays demonstrated that C . bovis -containing serum inhibited M2-TAMs polarization in human hepatocellular carcinomas cells. C . bovis was found to have 22 active components of which 11 were detected in the bloodstream. The anti-neoplastic activity of C . bovis lies in suppressing M2-TAM polarization by modulation of the Wnt/B-catenin pathway. In vitro and in vivo experiments have shown that C . bovis suppresses M2-TAM polarization and halts the Wnt signaling pathway. The inhibitory effect of C . bovis on M2-TAM was reversed by SKL2001, a Wnt agonist, which highlights C . bovis ’s selectivity and specificity. C . bovis inhibits M2-TAM polarization by modulating the Wnt/ β-catenin pathway, thus impeding liver cancer growth. Owing to the “cross-talk” between transforming growth factor-β (TGF-β) signaling pathways, this paper highlights the potential significance of C . bovis in controlling the tumor microenvironment not only through hindering the polarization of M2-TAMs via the Wnt signaling pathway, but also by downregulating TGF-β. Therefore, C . bovis serves as an igniter to fuel a cascade of signaling events that culminates in the regression of the tumor microenvironment by compromising oncogenesis and angiogenesis. TGF-β is also known for its pro-fibrotic properties. Therefore, C . bovis may play a pivotal role in treating liver fibrosis by downregulating TGF-β, thus hindering oncogenesis, angiogenesis and liver fibrosis. Hence, the “domino effect”.
THE MECHANISM FOR DEVELOPING DIGITAL EDUCATION SKILLS
Authors:   Doctoral student at Chirchik State Pedagogical University, Uzbekistan, Rinadovna Begisheva Nailya
Published: November 2024

The rapid digital transformation of education has emphasized the necessity for developing digital education skills among learners, educators, and institutions. This article explores the mechanisms for fostering these skills, focusing on critical components such as infrastructure, pedagogical integration, and training programs. It highlights the roles of key stakeholders, including educators, students, policymakers, and institutions, in creating a sustainable and inclusive digital learning environment. The study also examines emerging technologies like artificial intelligence (AI), virtual and augmented reality (VR/AR), and blockchain, discussing their potential to simplify and enhance skill acquisition. By addressing challenges such as the digital divide, lack of training, and socio-economic barriers, this paper provides actionable strategies for implementing digital education skills at scale. The insights presented aim to guide stakeholders in building resilient education systems equipped to meet the demands of a technology-driven future.
THE TASKS OF ORGANIZING PEDAGOGICAL EXPERIMENTAL WORK ON DEVELOPING STUDENTS’ CREATIVE ABILITIES
Authors:   Independent researcher at GulSU, Uzbekistan, Saodat Julmanova
Published: November 2024

The article explores the pedagogical strategies and methodologies involved in organizing experimental work to enhance students’ creative abilities. Creativity is increasingly recognized as a vital skill in education, fostering problem-solving, innovation, and adaptability. This paper examines key tasks associated with the planning, implementation, and evaluation of pedagogical experiments aimed at cultivating creativity. A systematic approach, involving collaborative learning, integration of creative tasks into the curriculum, and assessment of outcomes, is highlighted. The importance of teacher training, resource allocation, and feedback mechanisms is also discussed. Recommendations for future research and practical applications in diverse educational contexts are provided.