bluuebunny/crossref_metadata_2025 huggingface dataset:
Natural Disasters and Human Development in Asia–Pacific: The Role of External Debt
Authors: Brueckner Markus , Dahal Sudyumna , Lin Haiyan
Published: June 2024

The average country in Asia–Pacific experiences more natural disasters than average countries of other developing regions. This paper presents stylized facts on natural disasters, human development, and external debt in Asia–Pacific. The paper also contains estimates of the effects that natural disasters have on human development. Controlling for country- and time-fixed effects, the dynamic panel model estimates show that external debt has a mitigating effect on the adverse impacts that natural disasters have on human development; in countries with low external debt-to-GDP ratios, natural disasters significantly decrease the human development index, but not so in countries with high external debt-to-GDP ratios. External debt (i.e., borrowing from abroad) is a financial contract for obtaining resources from abroad (i.e., imports of goods and services). When a country experiencing a natural disaster borrows from abroad to increase imports of goods and services, the population suffers less when a natural disaster strikes. Natural disasters destroy goods and capital (e.g., food, machinery, buildings, and roads) in the countries in which they occur. If imports of goods and services do not increase, then the population has less goods and services to consume following a natural disaster. By increasing imports, which are mirrored on the financial side by an increase in external debt, the population of a country that was struck by a natural disaster can experience consumption smoothing. As the incidence of natural disasters increases globally, a policy recommendation for disaster-prone countries, supported by the empirical results of this paper, is the need for deeper and innovative mechanisms of access to international financing, including reforms in both domestic and international financial systems. The paper’s most significant contribution is the unique lens through which it analyzes the often-studied subject of natural disasters. Rather than looking at disasters as merely adverse events and debt as an unwelcome obligation in isolation, it connects the two and uncovers the paradoxically positive and beneficial role a healthy level of external debt can play in mitigating the adverse effects of these disasters. It provides a fresh perspective, a shift in thinking that may immensely benefit external debt and disaster management policies.
Mining versus Indigenous Protected and Conserved Areas: Traditional Land Uses of the Anisininew in the Red Sucker Lake First Nation, Manitoba, Canada
Authors: Onyeneke Chima , Harper Bruce , Thompson Shirley
Published: June 2024

Indigenous traditional land uses, including hunting, fishing, sacred activities, and land-based education at the Red Sucker Lake First Nation (RSLFN) in Manitoba, Canada, are impacted by mining. The Red Sucker Lake First Nation (RSLFN) people want their territories’ land and water to be protected for traditional uses, culture, and ecological integrity. Towards this goal, their Island Lake Tribal Council sought support for an Indigenous-protected and conserved area (IPCA) in their territory, outside of existing mining claims, but without success. The two-eyed seeing approach was adopted in this study. Traditional land use mapping and interviews were undertaken with 21 Indigenous people from the RSLFN, showing that many traditional land uses are concentrated on greenstone belts. The interviews revealed that mining exploration has resulted in large petroleum spills, noise distress, private property destruction, wildlife die-offs, and animal population declines. These issues negatively impact RSLFN’s traditional land use practices, ecosystem integrity, and community health. Governments need to partner with Indigenous communities to reach their biodiversity targets, particularly considering northern Canada’s peatlands, including those in the RSLFN territory, surpassing Amazon forests for carbon storage. The role of critical minerals in renewable energy and geopolitics has colonial governments undermining Indigenous rights, climate stabilization, and biodiversity to prioritize extractivism. Mining at the RSLFN has environmental impacts from exploration to decommissioning and after, as well as the massive infrastructure required that includes roads, hydro, and massive energy supplies, with a proposed multimedia national Northern Corridor to export RSLFN’s resources and other resources to six ports.
Integrating Virtual Walkthroughs for Subjective Urban Evaluations: A Case Study of Neighbourhoods in Sheffield, England
Authors: Roychowdhury Sneha , Mazumdar Suvodeep , Thakker Dhavalkumar , Checco Alessandro , Lanfranchi Vitaveska , Goodchild Barry
Published: June 2024

This study explores the correlation between residents’ subjective assessments of urban neighbourhoods, obtained through virtual walkthroughs, and objective measures of deprivation. Our study was set within a specific city in the United Kingdom, with neighbourhoods selected based on Indices of Multiple Deprivation (IMD). We invited residents in the UK through Prolific, a crowdsourcing platform. Employing complete case analysis, TF-IDF keyword extraction, the Kruskal–Wallis test, and Spearman’s rank-order correlation, our study examines the alignment between subjective assessments and existing deprivation measures (IMD). The results reveal a nuanced relationship, suggesting potential subjective biases influencing residents’ perceptions. Despite these complexities, the study highlights the value of virtual walkthroughs in offering a holistic overview of neighbourhoods. While acknowledging the limitations posed by subjective biases, we argue that virtual walkthroughs provide insights into residents’ experiences that potentially complement traditional objective measures of deprivation. By capturing the intricacies of residents’ perceptions, virtual walkthroughs contribute to a more comprehensive understanding of neighbourhood deprivation. This research informs future endeavours to integrate subjective assessments with objective measures for robust neighbourhood evaluations.
Toward a Representation of Semantic Change in Linked Data
Authors: Khan Anas Fahad , Frontini Francesca
Published: June 2024

In this article, we introduce a new framework, the Intensional–Ontological Model (IOM), for representing meaning, and especially for representing semantic change, in linguistic linked data resources. This framework, which makes use of previous work in the literature on lexical semantics and ontologies, is intended to help clarify what we mean when we model semantic change and to assist in elaborating different ontology patterns for doing so. In this work, we assume a simple architecture, one which is at the basis of the well-known OntoLex-Lemon vocabulary and which consists of one or more lexicons linked to an ontology. Our model, which is based on this architecture and informed by previous work on word senses and ontologies, is intended to provide a clear interpretation for the modelling of both onomasiological and semiasological changes, in both static and dynamic versions. This article describes how the IOM framework represents word meaning as the relationship between a word and an ontological concepts in the ’static’ case, demonstrating that the IOM is compatible with OntoLex-Lemon (while at the same time providing a greater level of detail as to the meaning of the ’sense’ and ’reference’ relationships). It then goes on to detail how the IOM can help us understand how to model semantic shifts in linked data lexical resources with a focus on conceptual change and the addition of temporal information to semantic shift data.
Investigation of the Properties of High-Viscosity Modified Asphalt Binder under Hygrothermal Environments
Authors: Xing Mingliang , Li Guimin , Zhou Xiaowei , Liu Huan , Cao Zhulin , Li Zuzhong , Chen Huaxin
Published: June 2024

High-viscosity modified asphalt binder (HVMA) is used widely as a polymer-modified binder in porous asphalt pavement because it can improve the cohesiveness of the asphalt mixture. However, because of the high voidage in the mixture, HVMA is vulnerable to aging induced by temperature, oxygen, water, sunlight, and other climatic conditions, which degrades the performance of pavement. The properties of asphalt binder are affected adversely by the effects of hygrothermal environments in megathermal and rainy areas. Therefore, it is essential to study the aging characteristics of HVMA under the influence of hygrothermal environments to promote its application as a high-viscosity modifier. A hygrothermal cycle aging test (HCAT) was designed to simulate the aging of HVMA when rainwater was kept inside of the pavement after rainfall in megathermal areas. One kind of base bitumen and three kinds of HVMA (referred to as SBS, A, and B, respectively) were selected in this study. Short-term aging tests, hygrothermal cycling aging tests, and long-term aging tests were performed on the base bitumen and three kinds of modified asphalt binder. Fourier-transform infrared spectroscopy (FTIR), thermo-gravimetric analysis (TGA), and dynamic shear rheological (DSR) tests were used to evaluate the properties of the binders on the micro and macro scales. By comparing the index variations of the four binders before and after aging, the effects of the hygrothermal environment on the properties of HVMA were studied. It was found that the effects of the hygrothermal environment expedited the decomposition of the polymer and the formation of carbonyl groups compared with the TFOT and PAV test, which TGA confirmed further. Moreover, the thermal stability of the samples was improved after HCAT. In addition, the master curves of the complex modulus showed that hygrothermal cycles made the high-temperature rutting resistance of asphalt binder increase significantly. All of the results above verified that the effect of hygrothermal cycling could accelerate the aging of HVMA and shorten its service life.
Structural Optimization of Scarfing Machine with Acceleration Profile and Multi-Objective Genetic Algorithm Approach
Authors: Lee Sangbin , Lee Yoonjae , Park Byeonghui , Lee Changwoo
Published: June 2024

Scarfing is a type of flame treatment used to improve the quality of metal generated during steelmaking. It employs the principles of gas cutting to remove impurities and defects. Due to the high-temperature conditions and the need for uniform metal treatment, mechanical scarfing performed via a frame is preferred over manual hand scarfing. To achieve stable mechanical scarfing, a properly designed frame is essential. Generally, while using more material can create stable equipment, it also increases costs. Therefore, this study proposed a design method that selects an acceleration profile to minimize the shock on the frame during scarfing equipment operation while using a multi-objective genetic algorithm to minimize weight and maximize rigidity. Because modifying existing scarfing equipment based on the optimization results would incur additional costs and time, pre-optimizing through simulation before equipment fabrication is crucial. Optimization was achieved via the dimensional optimization of the existing frame equipment. As a result, the weight of each part and the deformation decreased by an average of 17.05 kg and 3.93%, respectively.
Unveiling the Effects of the COVID-19 Pandemic on Lung Cancer Surgery
Authors: Cozma Gabriel Veniamin , Muntean Calin , Faur Alaviana Monique , Gaborean Vasile , Petrache Ioan Adrian , Feier Catalin Vladut Ionut
Published: June 2024

The aim of this study is to investigate the impact of the COVID-19 pandemic on the surgical treatment of lung cancer patients. Data from patients who underwent surgery during the pandemic were analyzed and compared to pre-pandemic and post-pandemic periods. Multiple parameters were examined, and their changes yielded significant results compared to other periods of the study. The statistical analysis revealed a significant decrease in the number of surgical interventions during the pandemic (p < 0.001), followed by a significant rebound thereafter. During this period, there was a significant increase in the T stage of cancer compared to both pre-pandemic and post-pandemic periods (p = 0.027). Additionally, the mean Charlson comorbidity index score was significantly higher during the pandemic compared to the pre-pandemic period (p = 0.042). In this crisis period, a significant decrease was recorded in both the total hospitalization duration (p = 0.015) and the pre-operative hospitalization duration (p = 0.006). These findings provide evidence of significant changes in clinical and therapeutic strategies applied to lung cancer surgery patients during the study period. The pandemic has had a substantial and complex impact, the full extent of which remains to be fully understood.
Critical Hemorrhage Caused by a Size-Mismatched Extracorporeal Membrane Oxygenation Cannula in a Patient with Myotonic Dystrophy Type 1: A Case Report and Literature Review
Authors: Shin Changsik , Yoo Kwon Cheol , Kim Dae Hoon
Published: June 2024

Background and Objective: Although extracorporeal membrane oxygenation (ECMO) is an essential life-saving technique for patients with refractory cardiopulmonary shock, it can be fatal in certain cases. Case Presentation: A 19-year-old girl treated with ECMO presented with acute limb ischemia 2 days after cannula removal. The decannulation was performed percutaneously by an interventional cardiologist, and the vascular surgery department was consulted after the patient developed symptoms. The first suspected diagnosis was thrombosis due to incorrect use of the closure device. However, the artery had ruptured due to the insertion of a catheter with a cannula that was larger than the patient’s artery. Management and Outcome: Fortunately, excessive bleeding due to the size-mismatched cannula was prevented by an unintentional complication of the closing device, which saved the patient’s life. She underwent a right common femoral artery thrombectomy and patch angioplasty. Hospital guidelines have changed regarding the surgical removal of ECMO cannulas. Discussion: This report aims to highlight the importance of two aspects that are critical to a successful outcome: individualized cannula selection followed by precise insertion and removal and postoperative evaluation of a patient’s final status.
Development of an LC-HRMS/MS Method for Quantifying Steroids and Thyroid Hormones in Capillary Blood: A Potential Tool for Assessing Relative Energy Deficiency in Sport (RED-S)
Authors: Tuma Chiara , Thomas Andreas , Braun Hans , Thevis Mario
Published: June 2024

Relative energy deficiency in sport (RED-S) is a condition that arises from persistent low energy availability (LEA), which affects the hypothalamic–pituitary axis and results in alterations of several hormones in both male and female athletes. As frequent blood hormone status determinations using venipuncture are rare in sports practice, microsampling offers promising possibilities for preventing and assessing RED-S. Therefore, this study aimed at developing a liquid chromatography–high-resolution tandem mass spectrometry (LC-HRMS/MS) method for quantifying relevant steroids and thyroid hormones in 30 μL of capillary blood obtained using Mitra® devices with volumetric absorptive microsampling technology (VAMS®). The results of the study showed that all validation criteria were met, including a storage stability of more than 28 days in a frozen state (−18 °C) and 14 days at room temperature (20 °C). The validated assay provided precise (<12%) and accurate (<13%) results for all the target analytes. Furthermore, as a proof of concept, autonomously collected VAMS® samples from 50 female and male, healthy, active adults were analyzed. The sensitivity of all analytes was adequate to quantify the decreased hormone concentrations in the RED-S state, as all authentic samples could be measured accordingly. These findings suggest that self-collected VAMS® samples offer a practical opportunity for regular hormone measurements in athletes and can be used for early RED-S assessment and progress monitoring during RED-S recovery.
Discovery and Characterization of Four Aphelenchid Species from Cultivated Regions of Southern Alberta, Canada
Authors: Munawar Maria , Castillo Pablo , Yevtushenko Dmytro P.
Published: June 2024

The nematode family Aphelenchoididiae is considered fungal-feeding, predatory, or root hair feeders. Some members of this family are universally present in agricultural landscapes and are an integral part of soil health and conservation studies. In the present soil nematode biodiversity survey, we detected four species of the genera Aphelenchus, Aphelenchoides, and Robustodorus. Because fungal-feeding nematodes from southern Alberta have not previously been reported, we conducted a detailed morphological and molecular investigation, identifying these species as Aphelenchus avenae, Aphelenchoides limberi, Aphelenchoides prairiensis n. sp. and Robustodorus paramegadorus n. sp. The first two species we document as new records from southern Alberta, whereas A. prairiensis n. sp. and R. paramegadorus n. sp. we describe in detail as new taxa. Briefly, A. prairiensis n. sp. is an amphimictic species having 4 lateral lines; hemispherical anteriorly flattened lip region; delicate stylet and swelling-like stylet knobs; excretory pore at the posterior edge of nerve ring. Female tail conical, gradually tapering towards a truncated end with single mucro. Spicule 23.0 (20.0–25.0) µm long having elongated rounded condylus, small, blunt conical rostrum, and lamina that gradually tapers towards the rounded distal end; three pairs of caudal papillae were present on the male tail. Robustodorus paramegadorus n. sp., is a parthenogenetic species with 3 lines in the lateral fields; lip region rounded, anteriorly flattened; stylet robust, with knobs rounded to bean-shaped; excretory pore located posterior to nerve ring; reproductive components were quite indiscernible with a short 24.0 (18.0–27.0) µm post-vulval uterine sac; tail conical, ending with pointed to wedge-shaped tip. We performed molecular characterizations for each species and constructed phylogenetic trees to study the phylogenetic relationship of these aphelenchid species. The discovery of A. prairiensis n. sp. and R. paramegadorus n. sp. indicates that soil nematode diversity is relatively unexplored in southern Alberta. The findings of this study will significantly enhance the identification processes and may contribute towards future soil health and biodiversity efforts.
Optimization of an Ultrasound-Assisted Extraction Technique and the Effectiveness of the Sunscreen Components Isolated from Bletilla striata
Authors: Luo Yan , Tan Zhenyuan , Zhang Hancui , Tang Shuai , Sooranna Suren R. , Xie Jizhao
Published: June 2024

Bletilla striata is the dried tuber of B. striata (Thund.) Reichb.f., which has antibacterial, anti-inflammatory, anti-tumor, antioxidant and wound healing effects. Traditionally, it has been used for hemostasis therapy, as well as to treat sores, swelling and chapped skin. In this study, we used the ultraviolet (UV) absorbance rate of B. striata extracts as the index, and the extraction was varied with respect to the solid–liquid ratio, ethanol concentration, ultrasonic time and temperature in order to optimize the extraction process for its sunscreen components. The main compounds in the sunscreen ingredients of Baiji (B. striata) were analyzed using ultra-high-performance liquid chromatography combined with quadrupole time-of-flight tandem mass spectrometry. The sunscreen properties were subsequently evaluated in vitro using the 3M tape method. The results show that the optimal extraction conditions for the sunscreen components of B. striata were a solid–liquid ratio of 1:40 (g/mL), an ethanol concentration of 50%, an ultrasonic time of 50 min and a temperature of 60 °C. A power of 100 W and an ultrasonic frequency of 40 Hz were used throughout the experiments. Under these optimized conditions, the UV absorption rate of the isolated sunscreen components in the UVB region reached 84.38%, and the RSD was 0.11%. Eighteen compounds were identified, including eleven 2-isobutyl malic acid glucose oxybenzyl esters, four phenanthrenes, two bibenzyl and one α-isobutylmalic acid. An evaluation of the sunscreen properties showed that the average UVB absorption values for the sunscreen samples from different batches of B. striata ranged from 0.727 to 1.201. The sunscreen ingredients of the extracts from B. striata had a good UV absorption capacity in the UVB area, and they were effective in their sunscreen effects under medium-intensity sunlight. Therefore, this study will be an experimental reference for the extraction of sunscreen ingredients from the B. striata plant, and it provides evidence for the future development of B. striata as a candidate cosmetic raw material with UVB protection properties.
Role of Functional Groups in Tuning Luminescence Signature of Solution-Processed Graphene Quantum Dots: Experimental and Theoretical Insights
Authors: Ke Zhicheng , Azam Muhammad , Ali Shujat , Zubair Muhammad , Cao Yu , Khan Abbas Ahmad , Hassan Ali , Xue Wei
Published: June 2024

Zero-dimensional graphene quantum dots (GQDs) present unique optoelectronic properties in the large-spectrum range from UV to visible. However, the origin of luminescence in GQDs is still a debatable question. Therefore, the present work investigates the features of trap-mediated and edge-state-functionalized group-associated luminescence enhancement of GQDs. The attached functional groups’ involvement in the upsurge of photoluminescence has been discussed theoretically as well as experimentally. In addition, the role of the aromatic ring, the functional group attached, and their positions of attachment to the aromatic ring to tune the emission wavelength and Raman modes have been elucidated theoretically as well as experimentally. We found that in the case of the –OH group attached outside of the aromatic ring, the long-range π hybridization dominates, which suggests that the emission from this model can be dictated by long-range π hybridization. In particular, we found that oxygen-containing functional groups attached outside of the aromatic ring are the main source of the luminescence signature in GQDs. Furthermore, density functional theory (DFT) indicates that the –OH functional group attached outside of the aromatic ring perfectly matched with our experimental results, as the experimental bandgap (2.407 eV) is comparable with the theoretical simulated bandgap (2.399 eV) of the –OH group attached outside of the aromatic ring.
Beneficial In Vitro Effects of Polysaccharide and Non-Polysaccharide Components of Dendrobium huoshanense on Gut Microbiota of Rats with Type 1 Diabetes as Opposed to Metformin
Authors: Xu Haijun , Liu Zhu , Xu Wen , Zhang Yafei
Published: June 2024

The extract of Dendrobium huoshanense, a traditional Chinese medicinal and food homologous plant belonging to the family Orchidaceae, was previously reported to have hypoglycemic and antioxidant effects. In this study, the direct effects of polysaccharide (DHP) and non-polysaccharide (NDHP) components of D. huoshanense, as well as its water extract (DHWE) were compared with that of metformin (an antidiabetic drug) on the gut microbiota (collected from fecal flora) of rats with streptozotocin-induced type 1 diabetes (T1D) using an in vitro fermentation method. The results showed that DHWE, DHP, and NDHP reduced pH and increased bacterial proliferation and short-chain fatty acid (SCFA) content in fermentation broth. DHWE, DHP, NDHP and metformin promoted the production of acetic and propionic acid, acetic acid, propionic acid and butyric acid, and propionic acid, respectively. DHWE, DHP, and NDHP reduced the abundance of Proteobacteria (subdominant pathogenic bacteria) and increased the abundance of Firmicutes (dominant beneficial gut bacteria). NDHP also reduced the abundance of Bacteroidetes (beneficial and conditional pathogenic). Metformin increased the abundance of Proteobacteria and reduced the abundance of Firmicutes and Bacteroidetes. At the genus level, NDHP promoted the proliferation of Megamonas and Megasphaera and decreased harmful bacteria (e.g., Klebsiella), and DHP increased the abundance of Prevotellaceae (opportunistic and usually harmless). By contrast, metformin increased the abundance of harmful bacteria (e.g., Citrobacter) and reduced the abundance of beneficial bacteria (e.g., Oscillospira). Our study indicates that DHWE, DHP, and NDHP are potentially more beneficial than metformin on the gut microbiota of T1D rats in vitro.
Neuronal Excitation Induces Tau Protein Dephosphorylation via Protein Phosphatase 1 Activation to Promote Its Binding with Stable Microtubules
Authors: Yagishita Sosuke , Shibata Megumi , Furuno Akiko , Wakatsuki Shuji , Araki Toshiyuki
Published: June 2024

The tau protein is a microtubule-associated protein that promotes microtubule stabilization. The phosphorylation of the tau protein has been linked to its dissociation from microtubules. Here, we examined the relationship between neuronal depolarization activity and tau protein phosphorylation by employing model systems in culture as well as in vivo. The KCl-evoked depolarization of cultured neurons has often been used to investigate the effects of neuronal activity. We found dephosphorylation at AT8 sites (S202, T205), T212, AT180 sites (T231, S235), and S396 in KCl-simulated cultured neurons. We also found that the KCl-induced tau protein dephosphorylation increases the level of the tau protein fractionated with stable microtubules. In an in vivo experiment, we demonstrated that the exposure of mice to a new environment activates protein phosphatase 1 in the mouse hippocampus and induces tau protein dephosphorylation. We also found an increased amount of the tau protein in a stable microtubule fraction, suggesting that the dephosphorylation of the tau protein may lead to its increased microtubule association in vivo. These results suggest that the association of microtubules with tau proteins may be regulated by the tau protein phosphorylation status affected by neuronal electrical activity.
Effect of the Administration of Cordyceps militaris Mycelium Extract on Blood Markers for Anemia in Long-Distance Runners
Authors: Nakamura Akira , Shinozaki Eri , Suzuki Yoshio , Santa Kazuki , Kumazawa Yoshio , Kobayashi Fumio , Nagaoka Isao , Koikawa Natsue
Published: June 2024

In the present study, we conducted a placebo-controlled, double-blind, parallel-group comparison trial in which an extract of Cordyceps militaris (CM) mycelium was administered to long-distance runners for 16 weeks during the pre-season training period and blood test markers for anemia were investigated. The results indicated that the change rates of serum ferritin levels were moderately increased in the CM group (n = 11) but decreased in the placebo group (n = 11) during the study period, and the levels were significantly increased in the CM group compared with those in the placebo group at 4 weeks and 8 weeks after the test food intake (p < 0.05). Moreover, the change rates of hemoglobin and hematocrit were significantly increased in the CM group compared with those in the placebo group at 8 weeks after the test food intake (p < 0.05). These observations suggest that the intake of test food containing Cordyceps militaris mycelium extract is expected to effectively maintain the hemoglobin and hematocrit levels in long-distance runners, possibly via the suppression of the decrease in iron storage, which is reflected by serum ferritin, during pre-season training. Furthermore, the levels of creatine kinase were increased above the normal range in both the placebo and CM groups at registration. Interestingly, the creatine kinase levels were significantly decreased in the CM group compared with those in the placebo group at 16 weeks after the test food intake (p < 0.05). These results suggest that Cordyceps militaris mycelium extract exhibits a protective action on the muscle damage observed in long-distance runners and may suppress muscle injury. Together, these observations suggest that Cordyceps militaris mycelium extract exhibits an improving effect on the markers for not only anemia, but also muscle injury in long-distance runners during pre-season training.
The Effect of Sargassum fusiforme and Fucus vesiculosus on Continuous Glucose Levels in Overweight Patients with Type 2 Diabetes Mellitus: A Feasibility Randomized, Double-Blind, Placebo-Controlled Trial
Authors: Geurts Karlijn A. M. , Meijer Sjoerd , Roeters van Lennep Jeanine E. , Wang Xi , Özcan Behiye , Voortman Gardi , Liu Hongbing , Castro Cabezas Manuel , Berk Kirsten A. , Mulder Monique T.
Published: June 2024

Background: Brown seaweed is promising for the treatment of type 2 diabetes mellitus (T2DM). Its bioactive constituents can positively affect plasma glucose homeostasis in healthy humans. We investigated the effect of the brown seaweeds Sargassum (S.) fusiforme and Fucus (F.) vesiculosus in their natural form on glucose regulation in patients with T2DM. Methods: We conducted a randomized, double-blind, placebo-controlled pilot trial. Thirty-six participants with T2DM received, on a daily basis, either 5 g of dried S. fusiforme, 5 g of dried F. vesiculosus, or 0.5 g of dried Porphyra (control) for 5 weeks, alongside regular treatment. The primary outcome was the between-group difference in the change in weekly average blood glucose levels (continuous glucose monitoring). The secondary outcomes were the changes in anthropometrics, plasma lipid levels, and dietary intake. The data were analyzed using a linear mixed-effects model. Results: The change in weekly average glucose levels was 8.2 ± 2.1 to 9.0 ± 0.7 mmol/L (p = 0.2) in the S. fusiforme group (n = 12) and 10.1 ± 3.3 to 9.2 ± 0.7 mmol/L (p = 0.9) in the F. vesiculosus group (n = 10). The between-group difference was non-significant. Similarly, no between-group differences were observed for the changes in the secondary outcomes. Discussion: A daily intake of 5 g of fresh, dried S. fusiforme or F. vesiculosus alongside regular treatment had no differential effect on weekly average blood glucose levels in T2DM.
Impact of Preoperative Malnutrition on Patients with Pancreatic Neoplasms Post-Duodenopancreatectomy: A Retrospective Cohort Study
Authors: Pellegrinelli Alvarez , Mancin Stefano , Brolese Alberto , Marcucci Stefano , Roat Ornella , Morenghi Emanuela , Morales Palomares Sara , Cattani Daniela , Lopane Diego , Dacomi Alessandra , Coldani Chiara , Tomaiuolo Giuseppina , Dal Bello Susy , Capretti Giovanni , Mazzoleni Beatrice
Published: June 2024

Background: Preoperative malnutrition is a significant factor in patients with pancreatic tumors undergoing pancreaticoduodenectomy. The aim of this study was to assess the association between preoperative malnutrition and delayed discharge within a ten-day timeframe and potential correlations between preoperative malnutrition and postoperative surgical complications. Methods: A retrospective cohort study was conducted, recruiting a final sample of 79 patients with benign or malignant cephalic pancreatic tumors from 2015 to 2022. The risk of malnutrition was assessed using the Malnutrition Universal Screening Tool, while length of hospital stay and relevant clinical data were extracted from clinical documentation. Results: The preoperative malnutrition risk was high in 21.52% of the sample, moderate in 36.71%, and low in 41.77%. Body mass index (BMI) (p = 0.007) and postoperative surgical complications (p < 0.001) were significantly correlated with delayed discharge. No statistically significant differences were found between levels of malnutrition risk and delayed discharge (p = 0.122), or postoperative surgical complications (p = 0.874). Conclusions: Postoperative complications and BMI emerge as significant risk factors. The limited sample size may have compromised the collection of homogeneous and significant data. Future studies should evaluate the implementation of personalized nutritional screening tools, nutritional assessment plans, and the involvement of specialized health professionals.
Remote Assisted Home Dressing vs. Outpatient Medication of Central Venous Catheter (Peripherally Inserted Central Venous Catheter): Clinical Trial A.R.C.O. (Remote Assistance Oncology Caregiver)
Authors: Basili Paolo , Farina Ilaria , Terrenato Irene , Centini Jacopo , Volpe Nina , Rizzo Vanessa , Agoglia Laura , Paterniani Albina , Aprea Pasquale , Calignano Prisco , Petrone Fabrizio , Ciliberto Gennaro
Published: June 2024

Background: Management of PICC dressing can be performed at home by the patient through adequate training and telenursing. This trial verifies that the incidence of catheter-related complications in home patients, assisted by telenursing, is not greater than that observed in outpatients. Methods: This clinical trial is composed of 72 patients with malignant tumors who underwent long-term chemotherapy with PICC insertion. They were randomly divided into an experimental group (33 cases) and a calibration group (39 cases). The control group received outpatient dressing for the PICC at the hospital, while the experimental group received a telenursing intervention about the management of the PICC. The incidence of catheter-related infections, the ability of self-management, and a rough cost/benefit estimation were compared between the two groups. This trial was performed according to the CONSORT 2010 checklist. Results: The two groups do not significantly differ in relation to age, sex, and PICCs in terms of the body side insertion, the type of dressing, and the agents used for cleaning. The analysis of the results showed that in the home-managed group, the clinical events reported during the connection were higher when compared with the outpatient group (p < 0.001). The patients in the homecare group developed frequent complications resulting from skin redness (p < 0.001). Conclusion: The use of telenursing for patient education in cancer centers can reduce nurses’ working time, improving the self-management capacity of patients with a long-term PICC. This trial was retrospectively registered with the Clinical Trial Gov on the 18 May 2023 with registration number NCT05880420.
Orthopedic Surgery Position Enhances Safety in Adults with Cervical Rigidity during Cochlear Implantation
Authors: Lazzarin Chiara , Frisina Antonio
Published: June 2024

Cochlear implantation is the therapy used for patients with severe to profound sensorineural hearing loss. For the success of the surgery, it is important that each surgical step is performed with meticulous precision, starting from the correct patient position on the operating table. In elderly or obese patients, this can be difficult to achieve due to cervical rigidity. With this technical note, we want to describe a new position from orthopedic surgery to perform a posterior tympanotomy accurately, ensuring a safe procedure and avoiding unpleasant complications.
High-Repetition-Rate 2.3–2.7 µm Acousto-Optically Tuned Narrow-Line Laser System Comprising Two Master Oscillators and Power Amplifiers Based on Polycrystalline Cr2+:ZnSe with the 2.1 µm Ho3+:YAG Pulsed Pumping
Authors: Antipov Oleg , Eranov Ilya , Balabanov Stanislav , Dobryinin Anton , Getmanovskiy Yuri , Sharkov Valeriy , Yudin Nikolay
Published: June 2024

High-average-power narrow-linewidth tunable solid-state lasers in the wavelength region between 2 and 3 μm are attractive light sources for many applications. This paper reports a narrow-linewidth widely tunable laser system based on the polycrystalline Cr2+:ZnSe elements pumped by repetitively pulsed 2.1 µm Ho3+:YAG laser operating at a pulse rate of tens of kilohertz. An advanced procedure of ZnSe element doping and surface improvement was applied to increase the laser-induced damage threshold, which resulted in an increase in the output power of the Cr2+:ZnSe laser system. The high-average-power laser system comprised double master oscillators and power amplifiers: Ho3+:YAG and Cr2+:ZnSe laser oscillators, and Ho3+:YAG and Cr2+:ZnSe power amplifiers. The output wavelength was widely tuned within 2.3–2.7 µm by means of an acousto-optical tunable filter inside a Cr2+:ZnSe master oscillator cavity. The narrow-linewidth operation at the pulse repetition rate of 20–40 kHz in a high-quality beam with an average output power of up to 9.7 W was demonstrated.
In Vitro and In Vivo Anti-Inflammatory and Antidepressant-like Effects of Cannabis sativa L. Extracts
Authors: Shin Joonyoung , Choi Sangheon , Park A Yeong , Ju Suk , Kweon Bitna , Kim Dong-Uk , Bae Gi-Sang , Han Dongwoon , Kwon Eunjeong , Hong Jongki , Kim Sungchul
Published: June 2024

Cannabis sativa L. has been widely used by humans for centuries for various purposes, such as industrial, ceremonial, medicinal, and food. The bioactive components of Cannabis sativa L. can be classified into two main groups: cannabinoids and terpenes. These bioactive components of Cannabis sativa L. leaf and inflorescence extracts were analyzed. Mice were systemically administered 30 mg/kg of Cannabis sativa L. leaf extract 1 h before lipopolysaccharide (LPS) administration, and behavioral tests were performed. We conducted an investigation into the oxygen saturation, oxygen tension, and degranulation of mast cells (MCs) in the deep cervical lymph nodes (DCLNs). To evaluate the anti-inflammatory effect of Cannabis sativa L. extracts in BV2 microglial cells, we assessed nitrite production and the expression levels of inducible nitric oxide synthase (iNOS), cyclooxygenase (COX)-2, interleukin (IL)-1β, IL-6, and tumor necrosis factor (TNF)-α. The main bioactive components of the Cannabis sativa L. extracts were THCA (a cannabinoid) and β-caryophyllene (a terpene). Cannabis sativa L. leaf extract reduced the immobility time in the forced swimming test and increased sucrose preference in the LPS model, without affecting the total distance and time in the center in the open field test. Additionally, Cannabis sativa L. leaf extract improved oxygen levels and inhibited the degranulation of MCs in DCLNs. The Cannabis sativa L. extracts inhibited IL-1β, IL-6, TNF-α, nitrite, iNOS, and COX-2 expression in BV2 microglia cells. The efficacy of Cannabis sativa L. extracts was suggested to be due to the entourage effect of various bioactive phytochemicals. Our findings indicate that these extracts have the potential to be used as effective treatments for a variety of diseases associated with acute inflammatory responses.
Garlic Cellulosic Powders with Immobilized AgO and CuO Nanoparticles: Preparation, Characterization of the Nanocomposites, and Application to the Catalytic Degradation of Azo Dyes
Authors: Sebeia Nouha , Jabli Mahjoub , Sonsudin Faridah
Published: June 2024

Nanomaterials have attracted specific consideration due to their specific characteristics and uses in several promising fields. In the present study, Chondrilla juncea was employed as a biological extract to facilitate the reduction of copper and silver ions within garlic peel powders. The resulting garlic-CuO and garlic-AgO nanocomposites were characterized using several analytical methods including FTIR, TGA/DTG, SEM, TEM, and XRD analyses. The garlic peel exhibited a rough surface. The nanoparticles were evenly dispersed across its surface. The incorporation of CuO and AgO nanoparticles affected the crystal structure of garlic peel. The establishment of CuO and AgO nanoparticles was evidenced by the highest residual mass values observed for the prepared nanocomposites. The thermogravimetric analysis showed that the prepared nanocomposites had lower thermal stability compared with garlic peel powders. The prepared nanocomposites were used for catalytic degradation of naphthol blue black B and calmagite. The decolorization process depended on the quantity of H2O2, initial concentration of azo dyes, duration of contact, and temperature of the bath. The calculated activation energy (Ea) values for the garlic-CuO nanocomposites were found to be 18.44 kJ mol−1 and 23.28 kJ mol−1 for calmagite and naphthol solutions, respectively. However, those calculated for garlic-AgO nanocomposites were found to be 50.01 kJ mol−1 and 12.44 kJ mol−1 for calmagite and naphthol, respectively.
Seaweed as Basis of Eco-Sustainable Plastic Materials: Focus on Alginate
Authors: Santana Ismael , Felix Manuel , Bengoechea Carlos
Published: June 2024

Seaweed, a diverse and abundant marine resource, holds promise as a renewable feedstock for bioplastics due to its polysaccharide-rich composition. This review explores different methods for extracting and processing seaweed polysaccharides, focusing on the production of alginate plastic materials. Seaweed emerges as a promising solution, due to its abundance, minimal environmental impact, and diverse industrial applications, such as feed and food, plant and soil nutrition, nutraceutical hydrocolloids, personal care, and bioplastics. Various manufacturing techniques, such as solvent casting, injection moulding, and extrusion, are discussed for producing seaweed-based bioplastics. Alginate, obtained mainly from brown seaweed, is particularly known for its gel-forming properties and presents versatile applications in many sectors (food, pharmaceutical, agriculture). This review further examines the current state of the bioplastics market, highlighting the growing demand for sustainable alternatives to conventional plastics. The integration of seaweed-derived bioplastics into mainstream markets presents opportunities for reducing plastic pollution and promoting sustainability in material production.
In Vitro and In Vivo Drug Release from a Nano-Hydroxyapatite Reinforced Resorbable Nanofibrous Scaffold for Treating Female Pelvic Organ Prolapse
Authors: Chen Yi-Pin , Lo Tsia-Shu , Chien Yu-Han , Kuo Yi-Hua , Liu Shih-Jung
Published: June 2024

Pelvic prolapse stands as a substantial medical concern, notably impacting a significant segment of the population, predominantly women. This condition, characterized by the descent of pelvic organs, such as the uterus, bladder, or rectum, from their normal positions, can lead to a range of distressing symptoms, including pelvic pressure, urinary incontinence, and discomfort during intercourse. Clinical challenges abound in the treatment landscape of pelvic prolapse, stemming from its multifactorial etiology and the diverse array of symptoms experienced by affected individuals. Current treatment options, while offering relief to some extent, often fall short in addressing the full spectrum of symptoms and may pose risks of complications or recurrence. Consequently, there exists a palpable need for innovative solutions that can provide more effective, durable, and patient-tailored interventions for pelvic prolapse. We manufactured an integrated polycaprolactone (PCL) mesh, reinforced with nano-hydroxyapatite (nHA), along with drug-eluting poly(lactic-co-glycolic acid) (PLGA) nanofibers for a prolapse scaffold. This aims to offer a promising avenue for enhanced treatment outcomes and improved quality of life for individuals grappling with pelvic prolapse. Solution extrusion additive manufacturing and electrospinning methods were utilized to prepare the nHA filled PCL mesh and drug-incorporated PLGA nanofibers, respectively. The pharmaceuticals employed included metronidazole, ketorolac, bleomycin, and estrone. Properties of fabricated resorbable scaffolds were assessed. The in vitro release characteristics of various pharmaceuticals from the meshes/nanofibers were evaluated. Furthermore, the in vivo drug elution pattern was also estimated on a rat model. The empirical data show that nHA reinforced PCL mesh exhibited superior mechanical strength to virgin PCL mesh. Electrospun resorbable nanofibers possessed diameters ranging from 85 to 540 nm, and released effective metronidazole, ketorolac, bleomycin, and estradiol, respectively, for 9, 30, 3, and over 30 days in vitro. Further, the mesh/nanofiber scaffolds also liberated high drug levels at the target site for more than 28 days in vivo, while the drug concentrations in blood remained low. This discovery suggests that resorbable scaffold can serve as a viable option for treating female pelvic organ prolapse.
Economic Dispatch of Combined Cycle Power Plant: A Mixed-Integer Programming Approach
Authors: López Hernández Octavio , Romero Romero David , Badaoui Mohamed
Published: June 2024

In this article, we present a modification to the Economic Dispatch (ED) model that addresses the non-convex nature of the cost curves associated with a Combined Cycle Power Plant (CCPP). Incorporating a binary variable provides greater precision in solving the combinatorial problem in only one simulation and, most importantly, demonstrates cost minimization among the three different cost curve models for dispatching the CCPP. Our results highlight the importance of considering different demand scenarios based on a reference forecast for one day ahead. Therefore, piecewise modeling is more feasible for solving the non-convex problem, showing greater accuracy regarding the operational state of the CCPP and avoiding the cost overestimation that occurs with traditional models. Moreover, it allows the operators to manage costs better and optimize generation potential, ultimately showing economic benefits for the system operator.
Characteristics and Mechanisms of CO2 Flooding with Varying Degrees of Miscibility in Reservoirs Composed of Low-Permeability Conglomerate Formations
Authors: Luo Yun , Yang Shenglai , Zhang Yiqi , Kou Gen , Zhao Shuai , Zhao Xiangshang , Zhang Xing , Chen Hao , Wang Xiuyu , Xiao Zhipeng , Bai Lei
Published: June 2024

The reservoir type of the MH oil field in the Junggar Basin is a typical low-permeability conglomerate reservoir. The MH oilfield was developed by water injection in the early stage. Nowadays, the reservoir damage is serious, and water injection is difficult. There is an urgent need to carry out conversion injection flooding research to improve oil recovery. The use of CO2 oil-flooding technology can effectively supplement formation energy, reduce greenhouse gas emissions, and improve economic benefits. In order to clarify the feasibility of CO2 flooding to improve oil recovery in conglomerate reservoirs with low permeability, strong water sensitivity, and severe heterogeneity, this paper researched the impact of CO2 miscibility on production characteristics and mechanisms through multi-scale experiments. The aim was to determine the feasibility of using CO2 flooding to enhance oil recovery. This study initially elucidated the oil displacement characteristics of varying degrees of miscibility in different dimensions using slim tube experiments and long core experiments. Subsequently, mechanistic research was conducted, focusing on the produced oil components, changes in interfacial tension, and conditions for pore mobilization. The results indicate that the minimum miscibility pressure (MMP) of the block is 24 MPa. Under the slim tube scale, the increase in the degree of miscibility can effectively delay the gas breakthrough time; under the core scale, once the pressure reaches the near mixing phase, the drive state can transition from a non-mixed “closed-seal” to a “mixed-phase” state. Compared to the immiscible phase, the near-miscible and completely miscible phase can improve the final recovery efficiency by 9.27% and 18.72%. The component differences in the displacement products are mainly concentrated in the high-yield stage and gas breakthrough stage. During the high-yield stage, an increase in miscibility leads to a higher proportion of heavy components in the produced material. Conversely, in the gas breakthrough stage, extraction increases as the level of mixing increases, demonstrating the distinct extracting characteristics of different degrees of mixed phases. The core experiences significant variations in oil saturation mostly during the pre-gas stage. CO2 miscible flooding can effectively utilize crude oil in tiny and medium-sized pores during the middle stage of flooding, hence reducing the minimum threshold for pore utilization to 0.3 μm.