bluuebunny/crossref_metadata_2025 huggingface dataset:
Human Needs and Conflicts Experienced in The Film Turning Red By Domee Shi3
Authors: Annisa  , Fajar Rahmat , Solvera Esy
Published: December 2023

This study analyzes the fulfillment of human needs and the conflicts in fulfilling these needs by the main character in the film Turning Red by Domee Shi. The purpose of this study is to explain how the main character fulfills human needs and to find out the conflicts that occur in fulfilling human needs seen by the main character in the film Turning Red by Domee Shi. Researcher used a psychological approach. Researcher used a qualitative descriptive method. Sources of data in this study are scripts, images and dialogue from the film Turning Red by Domee Shi. In collecting data, researcher used documentation techniques. Then the data were analyzed using descriptive analysis. The results of the analysis in this study indicate that researcher found five levels of human needs using Abraham Maslow's hierarchy of needs theory, namely physiological needs, safety needs, love and belonging needs, self-esteem needs, and self-actualization needs. This study shows that human needs have been fulfilled by the main character in the film Turning Red by Domee Shi. Then, the researcher found three conflicts in fulfilling human needs, especially at the level of self-esteem and self-actualization using Kurt Lewin's conflict theory, namely approach-approach conflict, avoidance-avoidance conflict, and approach-avoidance conflict. This study shows that the main character has resolved conflicts in fulfilling human needs, especially at the level of self-esteem and self-actualization in the film Turning Red by Domee Shi.
Polluted Water Sensor Based on Carbon Quantum Dots/Alq3 Using Drop Casting and Spin Coating Techniques
Authors: Essa Lana Ali , Jamal Raied K.
Published: December 2023

Water quality sensors have recently received a lot of attention due to their impact on human health. Due to their distinct features, environmental sensors are based on carbon quantum dots (CQDs). In this study, CQDs were prepared using the electro-chemical method, where the structural and optical properties were studied. These quantum dots were used in the environmental sensor application after mixing them with three different materials: CQDs, Alq3 polymer and CQDs and Alq3 solutions using two different methods: drop casting and spin coating, and depositing them on silicon. The sensitivity of the water pollutants was studied for each case of the prepared samples after measuring the change in resistance of the samples at a temperature of 30 oC. Through the results, it was found that the highest sensitivity of sample 3 to the carbon continuous dot was in the case of the contaminant fructose and was 99.55%, while the highest sensitivity of sample 4 was for the one sensitive to the contaminant (mercury chloride) and was 81. As for sample 1, the highest sensitivity was in the case of detecting the contaminant lead chloride and was 80. The results showed that the best sensor was obtained using a spin-coating technique when the solution sample of CQDs+Alq3 was placed on a silicon slide in fructose and the sensitivity was 200%. This demonstrates the importance of quantum dots in measuring the sensitivity of water pollutants. The thin film thickness was measured to be 500 nm.
HUBUNGAN ANTARA EXPERIENCE ECONOMY, TOUR QUALITY, DAN TOUR SATISFACTION DI DESA WISATA TAMANMARTANI
Authors: Fauzi Gilang Ahmad , Rosyadi Fachrurrozi , Putra Tegar Satya , Murti Desideria Cempaka Wijaya , Prihatno
Published: December 2023

This study aims to analyze the relationship between the dimensions of experience economy, tour quality, and tour satisfaction in Tamanmartani tourist village. The dimensions of experience economy consist of education, entertainment, aesthetic, escapism. Each of the dimension reflects specific expectation that the tour participants have to the tour itself.

Through quantitative methods, questionnaires were used to collect data from tourists visiting Tamanmartani tourism village. A total of 100 respondents were involved in this study and the collected data were processed using Smart PLS.

The result of the analysis shows that the dimensions of experience economy have a positive impact on the perception of tour quality and tour satisfaction. The results provide a better understanding of how the interaction between these factors can shape the perception, behavior, and image of tourist destinations. This study provides valuable information for destination managers, local governments, and tourism industry stakeholders to design more effective strategies in developing Tamanmartani tourism village.
Organizing Russian as a foreign language teaching in schools in Asia, Africa and Latin America on the basis of a Russian online training package as an education export strategy
Authors: Rybakova Ekaterina Vladimirovna
Published: December 2023

The aim of the research is to substantiate the high relevance of expanding pre-university Russian language education programs abroad to increase the level of Russian higher education export in terms of boosting demand among young people from Asia, Africa and Latin America. The paper examines the current picture of pre-university forms of Russian teaching abroad and determines the most effective form; investigates the existing conditions for the implementation of this form in Asia, Africa and Latin America and identifies the type of Russian methodological support necessary for its scaling. The scientific novelty of the research lies in defining one of the key conditions for the successful expansion of pre-university Russian language teaching programs abroad that consists in the organization of teaching the subject “Russian language” in foreign schools through the implementation of digital methodological support in the form of a Russian online training package to assist countries that do not have long-term experience in the implementation of Russian as a foreign language training programs. As a result of the research, the prospects of promoting the inclusion of the subject “Russian language” in the programs of foreign schools as a second foreign language in Asia, Africa and Latin America have been substantiated, as this form of education contributes to the effective organization of pre-university Russian language learning and the creation of positive ideas about the scientific and technological development of Russia among schoolchildren, forming their motivation and communication competencies for admission and successful study in Russian universities.
Linguodidactic potential of authentic visual meme texts in Russian as a foreign language teaching (by the example of the implementation of the SAINT PETERSBURG linguocultural concept)
Authors: Kolomeytseva Ekaterina Borisovna , Matveev Andrei Pavlovich
Published: December 2023

The research aims to identify the linguodidactic potential of authentic texts that create the image of St. Petersburg (visual memes in souvenir products) within the framework of the linguistic and cultural studies course in Russian as a foreign language teaching. The paper discusses the ways of representing the information about St. Petersburg in various texts, compares the representation of the SAINT PETERSBURG concept in these texts. The conducted pedagogical research is of an applied nature: according to the results of the analysis, it has been found that the analyzed training manuals do not involve creative and interactive tasks and it has been also noted that certain micro-topics of the concept need to be supplemented. The authors have developed a block of tasks to solve this problem. The scientific novelty of the research lies in the fact that the paper explores visual meme texts about St. Petersburg reflecting the current socio-cultural information absent in the training manuals and also offers the methodological potential for including such texts in the practice of teaching linguoculturology in the Russian as a foreign language course (a set of tasks using visual memes is given). As a result of the research, it has been found that the training manuals on Russian as a foreign language containing texts about St. Petersburg need to be supplemented with up-to-date information to create a complete cultural picture for foreign students, for this purpose, authentic visual meme texts are suitable. As the examination of texts written by foreign students has shown, the students possess surface knowledge about the city. The authors have developed a block of tasks based on modern visual memes as an additional material about St. Petersburg in the course of linguistic and cultural studies about Russia. The tasks proposed by the authors are of a communicative and interactive nature.
The fable “The Star and the Comet” by V. A. Zhukovsky: The history of the text and meanings
Authors: Potashova Ksenia Alekseevna
Published: December 2023

The aim of the research is to identify the semantic component and artistic specificity of the images of celestial bodies in V. A. Zhukovsky’s poem “The Star and the Comet”. The paper is devoted to comparing Zhukovsky’s fable with a German source and considering the movement of poetic thought from the draft to the final version of the text; the mechanisms underlying the transformation of visible pictures of the universe into an artistic image with a high emotional impact are determined. The scientific novelty of the research consists in clarifying the factual basis of Zhukovsky’s writing of the fable “The Star and the Comet”, considering the creative history of the poem, interpreting it not only as a loose translation of the poetic study by Gottlieb Konrad Pfеffеl, but also as a result of superimposing the author’s own experimental observations of the movement of celestial bodies on the German source, which expands the understanding of cosmic imagery features in the aesthetics of Russian Romanticism. As a result of the research, the functional spectrum of the images of celestial bodies in Zhukovsky’s poem “The Star and the Comet” has been determined, the ratio of the national to the universal in these images has been revealed. Through textual and cultural-historical commentary, the mechanisms of poetic embodiment of the cosmos model as a fragment of the national worldview are traced, Zhukovsky’s handwritten materials are analyzed in relation to the intellectual realities of the 1820s.
The story “Where Sukpai Runs” by Jansi Kimonko from the point of view of ethnology: A view from the 21st century
Authors: Fetisova Lidia Evguenievna
Published: December 2023

The aim of this study is to identify the features of using ethnographic realities on the thematic and narrative levels in the story “Where Sukpai Runs” by Jansi Kimonko from the standpoint of modern humanistic knowledge. The scientific novelty of the work lies in the fact that the main focus is not on the mythopoetic component of the story, but on a range of ethnographic realities that have not previously attracted the attention of literary scholars. The article emphasizes the important structuring role of the author's poetic monologue about his homeland, the Sukpai River. Special attention is given to the intra-family relationships of the Kimonko clan against the backdrop of the traditional marital arrangements of the Udege people. The study underscores the deliberate nature of the author's positive attitude toward the changes that took place in the life of his people in the first third of the 20th century. As a result, the study showed that the description of the everyday life of the Udege people in the story plays not a secondary role, but serves as a unique artistic technique, allowing for the presentation of the cultural multiplicity of historical time.
Pemilihan Semivariogram Terbaik Berdasarkan Root Mean Square Error (RMSE) pada Data Spasial Eksplorasi Emas Awak Mas
Authors: Hendarwati Emy Khairil , Lepong Piter , Suyitno Suyitno
Published: December 2023

Semivariogram merupakan perangkat dasar geostatistik yang digunakan untuk memvisualisasi, memodelkan, dan menghitung autokorelasi spasial dari antar data dalam suatu variabel. Semivariogram dibedakan menjadi dua, yaitu semivariogram eksperimental dan semivariogram teoritis. Terdapat tiga jenis model semivariogram teoritis, yaitu model spherical, model eksponensial, dan model gaussian. Penelitian ini bertujuan untuk menentukan model semivariogram terbaik berdasarkan nilai RMSE terkecil. Data penelitian ini adalah data sekunder eksplorasi emas yang terdiri dari data drillhole sebanyak 101 data. Proses pemilihan model semivariogram dimulai dengan menghitung semivariogram eksperimental, melakukan analisis struktural dengan mencocokkan kurva semivariogram eksperimental dengan kurva semivariogram teoritis model spherical, model eksponensial, dan model gaussian, diperoleh nilai nugget, sill, dan range pada masing – masing model semivariogram, menghitung nilai RMSE pada model spherical, model eksponensial, dan model gaussian. Nilai RMSE pada model spherical sebesar 0,3259, model eksponensial sebesar 0,2655, dan model gaussian sebesar 0,3224. Berdasarkan hasil RMSE, model semivariogram terbaik dengan nilai RMSE terkecil adalah model eksponensial.
Perbandingan Nilai Resistivitas Menggunakan Metode Logging Resistivitas Listrik dan Electrical Resistivity Tomography (ERT)
Authors: Antony Nurvani , Lepong Piter , Wahidah Wahidah , Supriyanto Supriyanto , Djayus Djayus
Published: December 2023

Metode geolistrik sering digunakan untuk menginterpretasikan lapisan bawah permukaan yang dangkal. Namun dalam kenyataannya, metode ini memberikan pengukuran resistivitas bawah permukaan yang berbeda dengan metode log resistivitas. Selain itu, metode ini memiliki kelemahan dalam membaca lapisan tipis saat kedalaman pengukuran bertambah. Oleh karena itu, dilakukan penelitian ini untuk membandingkan metode geolistrik dan log resistivitas, serta menentukan faktor-faktor yang menyebabkan perbedaan pengukuran tersebut. Penelitian ini menggunakan data sekunder yang nantinya diolah menggunakan software tertentu. Data geolistrik diolah menggunakan Res2DINV untuk memperoleh penampang resistivitas 2D. Kemudian data log resistivitas diolah menggunakan WellCAD untuk memperoleh kurva resistivitas. Kedua hasil tersebut digabungkan dalam satu gambar untuk dibandingkan dan dianalisis perbedaannya. Hasil yang diperoleh menunjukan bahwa nilai resistivitas semu yang ditampilkan penampang geolistrik lebih kecil dibandingkan kurva resistivitas milik log resistivitas. Selain itu, terdapat sedikit perbedaan interpretasi antara keduanya, dimana metode geolistrik tidak dapat membaca lapisan tipis yang cukup dalam, seperti batubara, dan metode log resistivitas tidak dapat membaca lapisan clay.
Robo academic advisor: Can chatbots and artificial intelligence replace human interaction?
Authors: Thottoli Mohammed Muneerali , Alruqaishi Badria Hamed , Soosaimanickam Arockiasamy
Published: December 2023

Purpose: Chatbots and artificial intelligence (AI) have the potential to alleviate some of the challenges faced by humans. Faculties frequently swamped with teaching and research may find it difficult to act in a parental role for students by offering them individualized advice. Hence, the primary purpose of this study is to review the literature on chatbots and AI in light of their role in auto-advising systems. The authors aimed to gain insights into the most pertinent topics and concerns related to robo academic advisor and identify any gaps in the literature that could serve as potential avenues for further research.

Design/methodology/approach: The research employs a systematic literature review and bibliometric techniques to find 67 primary papers that have been published between 1984 and 2023. Using the Scopus database, the researchers built a summary of the literature on chatbots and AI in academic advice.

Findings: Chatbot applications can be a promising approach to address the challenges of balancing personalized student advising with automation. More empirical research is required, especially on chatbots and other AI-based advising systems, to understand their effectiveness and how they can be integrated into educational settings.

Research limitations/implications: This research’s sample size may restrict its findings’ generalizability. Furthermore, the study’s focus on chatbots may overlook the potential benefits of other AI technologies in enhancing robo academic advising systems. Future research could explore the impact of robo academic advisors in diverse societal backgrounds to gain a more comprehensive understanding of their implications.

Practical implications: Higher educational institutions (HEIs) should establish a robo academic advising system that serves various stakeholders. The system’s chatbots and AI features must be user-friendly, considering the customers’ familiarity with robots.

Originality/value: This study contributes to a better understanding of HEIs’ perceptions of the adoption of chatbots and AI in academic advising by providing insightful information about the main forces behind robo academic advising, illuminating the most frequently studied uses of chatbots and AI in academic advising.
Pflegeeinrichtungen im Klimawandel – Sachstand und Ansätze zur Problemlösung
Authors: Grewe Henny Annette , Janson Debora
Published: December 2023

Klimawandel und demografischer Wandel sind in ihrer Gleichzeitigkeit eine große Herausforderung für Einrichtungen der Pflege, vordringlich unter dem Aspekt zunehmender Hitzewellen. Prinzipiell fokussieren Anpassungsmaßnahmen an Hitze drei Ansätze: Die Reduktion der Exposition, die Reduktion der Sensibilität sowie die Optimierung der gesundheitlichen Versorgung. Beispiele in Deutschland zeigen Lösungswege, aber auch die Lücken gegenwärtiger Anpassungskonzepte. Vor allem in ambulanten Kontexten müssen sektorenübergreifende Strategien entwickelt und umgesetzt werden.
Los suelos y la vegetación del área de influencia de las obras de Yacyreta, provincia de Corrientes, Argentina
Authors: Escobar Edmundo H. , Carnevali Romeo , Contreras Hugo J. , Melgar Ricardo , Vallejos Luis L. , Ortigoza Ricardo , Matteio Humberto , Serra Pilar Y.
Published: December 2023

El objetivo principal de este trabajo es el inventario y evaluación de los récursos suelos y vegetación del área de influencia de la Presa de Yacyretá, a nivel de semidetalle, escala 1:50.000, en una superficie de 840.000 ha. El área recorre de sur a norte más de 30 km, cuyos puntos extremos se encuentran a los 27°15' y 28° de latitud sur.y de este a oeste 300 km (55°55' de longitud oeste del meridiano de Greenwich).

Se obtuvieron Cartas de Suelos, de aptitud potencial para riego y de geomorfología, escala 1:50.000. Mapas temáticos a escala 1:200.000; de vegetación; regiones de suelos; uso actual de la tierra; capacidad de uso; aptitud de las tierras para cultivos anuales y perennes; grandes grupos de suelos y de aluminio intercambiable.

La Memoria contiene los resultados relacionados a las cartas y mapas citados anteriormente, distribuidos en 6 tomos, compuestos de 12 volúmenes, a saber:Tomo I -Antecedentes, climas y suelos (4 volúmenes)Tomo II -Vegetación (2 volúmenes)Tomo III -Productividad de los suelos (1 volumen)Tomo IV -Geomorfología e hidrología de 100.000 ha (1 volumen)Tomo V -Aptitud para riego de 100.000 ha (1 volumen)Tomo VI -Cartas de suelos y mapas temáticos (3 volúmenes)

El trabajo es el resultado de la firma de un convenio entre el Gobierno Provincial y el Consejo Federal de Inversiones, en el mes de marzo de 1981, encomendándose la realización del estudio a la Estación Experimental del INTA - Corrientes, a través del Dpto. de Recursos Naturales.

Esta Memoria no fue publicada,por consiguiente la información detallada puede ser consultada en: Biblioteca INTA Corrientes (C.C.57-3400- Corrientes); Facultad de Ciencias Agrarias (UNNE) (Sgto.Cabral 2139 -3400- Corrientes); Instituto Correntino del Agua (Gobierno de la Provincia de Corrientes) (San Martín 2250 -3400- Corrientes) y Consejo Federal de Inversiones (San Martín 871 -5o piso- 1004 - Buenos Aires)
Zooplancton del Río Paraná Medio: variaciones temporales y distribucionales en el área de confluencia con el Río Paraguay
Authors: Bonetto Argentino A. , Corrales de Jacobo Marta A.
Published: December 2023

The distribution, composition and numeric density of zooplankton communities at the first reach of Middle Paraná River were studied at the crosssection “Corrientes-Resistencia", about 30 km downstream its confluence with Paraguay River, by means of monthly samplings from April/76 to December/79.

Samples were obtained one meter deph, fíltering 100 1 water with a 53 np mesh size sieve, at three stations: two located about 50 m from the margins (left at Corrientes and right at Chaco próvinces), and thé third at the centre of the section. Several Imnological parameters were recorded and water samples were taken to carry out current physical analysis at the laboratory.

The numeric density of zooplankters and its specific composition, though very variable, resutted quite elevated (between 1 and 195 ind/l, with a total of 127 species), becoming both valúes more elevated towards the right margin. This river skle is very influenced by Paraguay River, wbile the left one, practically receive only Paranean waters. In spite of that, most zooplanktonic characteristic species in numerosity and frequence were generaüy similar in both margins.
Ritmo diario de la fotosintesis, respiración, pigmentos y bacterias heterotróficas (Embalse del Río III, C´órdoba, Argentina)
Authors: Mariazzi Aldo A. , Romero M. Cristina , Conzonno Víctor H. , Di Siervi Miguel A.
Published: December 2023

The results of the variante analysis obtaíned show us the relevando of the diel and day-to-day viriations of the photosyndiesís, ehlorophylba and phaeopigments, specially during summer months, The, short-term variation observed is expiain by displacement of water masses with diffferent amoumts of phytoplankton. In winter, vertical circulation occurs, and the variability of those parameters decrease, Heterotrophic bacteria deosity was the variable with greatest change throughout the observaron period. The establishment of nocturnal eirculaticm and diumal stratification were not observed, being these changes seasonal depend.
Comunidades de aves acuáticas de la laguna Mar Chiquita (Córdoba, Argentina)
Authors: Bucher Enrique H. , Herrera Gerardo
Published: December 2023

Mar Chiquita is a large inland brackish water body of about 2,000 km2, with a salinity of around 100 °/oo. Its aquatic bird communities were studied throughout a year in three study areas, representative of the main habitat types found in the región. We collected information on species composition and abundance, as well as foraging behaviour, feeding site utilization and stomach contents.

In total we recorded 55 species. The richest community (both in number o f species and individuals) was found around the Rio Segundo estuary, while the less diverse corresponde to saline ponds near the coast. Summer migrant species (long range neartic migrants) included nine species and accounted for the 21% of the observed birds. Winter visitors included five species and made up 1% of bird numbers. Ecological guilds species composition and patterns of resource utilization are analyzed. They closely resemble those of marine estuarine and intertidal conditions. At present, the main adverse factors for the preservation of the local aviiauna are linked with planned stream regime modifications through dam building, and contamination due to industrialdevelopment along tributary rivers.
: Evaluation of the knowledge and attitudes about hypospadias of the parents of children diagnosed with hypospadias: A qualitative study
Authors: TEK Kadriye , ÇÖVENER ÖZÇELİK Çağrı
Published: December 2023

Purpose: The purpose of the study to determine the knowledge and attitudes of the parents of children diagnosed with hypospadias.

Methods: This descriptive study conducted on the families of children diagnosed with hypospadias and discharged from a pediatric surgery clinic in a state hospital in Istanbul between April 2018 and December 2018. Data collected with parent information form, type recorder, semi-structured interview. Content analysis was used to evaluate the qualitative data. Research results are reported according to the COREQ Checklist.

Results: After analyzing the interviews of the participants, eight themes have been created: “Inaccuracy of information about hypospadias”, “The fact that the information is not clear and understandable by the family”, “Anxiety about the surgery and the prognosis of the disease in the pre-operative period”, “Fears about the process and after the surgery”, “Positive emotions after surgery", "Negative emotions after surgery", "Supporting post-operative care", "Importance of cosmetic appearance",

Conclusion: It was found that the parents did not have enough information about hypospadias and the postoperative process adversely affected the attitudes of the parents towards the disease.
"OUR DISEASE OF NO HOPE”: A QUALITATIVE STUDY ON THE SUPPORTIVE CARE NEEDS OF WOMEN UNDER TREATMENT FOR GYNECOLOGICAL CANCER
Authors: GÜL Sidar
Published: December 2023

Background/Purpose: Identifying and managing unmet supportive care needs while caring for a patient with gynecological cancer is an important component of healthcare. The purpose of this study is to determine the supportive care needs of women receiving gynecological cancer treatment.

Methods: This study, using a qualitative research design, was conducted with 15 women diagnosed with gynecological cancer. Face-to-face interviews were conducted with the participants determined by the purposive sampling method until reached the saturation point. The interviews were held between January and May 2022.

Results: The mean age of the participants was 53.5±11.14, five of them were primary school graduates, nine of them had a medium income and 10 were married. Seven of the participants had tanus endometrial cancer and the mean diagnosis period was 10.4±2.5 months. As a result of the analysis of the data, five themes were determined. These themes; the continuity of the need for care, lack of social support, lack of sense of control, the desire to cope with uncertainty, and the lack of communication in the health institution.

Conclusion: It was determined that women who were treated for gynecological cancer had care needs that were not met and needed to be supported due to individual, economic, social and medical reasons. Supportive care needs of women receiving gynecological cancer treatment should be evaluated within the framework of a multidisciplinary team approach, and counseling and rehabilitation programs including symptom management and psychosocial support should be organized in order to improve coping methods with their diseases.
Functional Capacity in COVID-19 related Acute Respiratory Distress Syndrome Survivors
Authors: TURAN Zeynep , TOPALOĞLU Mahir , ÖZYEMİŞÇİ TAŞKIRAN Özden
Published: December 2023

Background/Purpose:: The aim of this retrospective study is to determine the functional capacity, global muscle weakness and quality of life in COVID-19 survivors. Acute respiratory distress syndrome survivors frequently develop impaired physical function, quality of life, and muscle weakness.

Methods: Acute respiratory distress syndrome survivors related to COVID-19 underwent standardized physical clinical evaluation, Medical Research Council-sumscore, hand-grip strength, 6-minute walk test, 5 repetition-chair-stand test, timed up and go test and Short form-36 evaluation following 4-6 weeks after hospital discharge in Physical Medicine and Rehabilitation Outpatient Clinic.

Results: Fifteen patients (10 men, 5 women) with median age 69 years and length of intensive care unit stay 10 days were analyzed. There were impairments in 6-minute walk test, 5 repetition-chair-stand test, hand-grip strength and, Role-physical, Role-emotional and Social functioning domains of Short form-36. 6-minute walk distance was negatively correlated with timed up and go. SF-physical functioning was positively correlated with hand-grip strength, Medical Research Council-sumscore and 5 repetition-chair-stand. SF-general health was positively correlated with hand-grip strength.

Conclusion: There were varying degrees of functional impairment in survivors. Therefore, it could add advantage to assess these patients after nearly 4-6 weeks following discharge in order to ascertain rehabilitation needs and giving appropriate therapies.
Acute Abdomen in Gynecology — Single University Centre Experiences
Authors: Habek Dubravko , Ristić Jadranka , Cerovac Anis
Published: December 2023

Background: Acute abdomen (AA) is a synonym for a condition caused by an acute disease of an intra-abdominal organ that requires urgent surgical intervention. The gynecological-obstetrical etiopathogenesis of AA is based on pathological events on the genital organs due to hemorrhagic, inflammatory, and ischemic/obstructive genesis, and is a significant reason for admission to emergency gynecological departments, and emergency surgery. Methods: A retrospective clinical research was performed from 2005 to 2021, from the surgical protocol of the University Department for Gynecology and Obstetrics, Clinical Hospital “Sveti Duh” in Zagreb. In the examined sixteen-year period, 703 patients (4.06%) had surgery with a diagnosis of AA. Results: The largest number of surgeries due to AA was performed in the age group of 21–45 years (74.40%), i.e., in the reproductive age, followed by 106 patients aged 46–52 years (15.07%), then 46 (6.54%) patients in children and adolescent age up to 20 years of age, then from 53–60 years 23 (3.27%) patients, and in the elderly >60 years old, with 5 (0.71%) patients. The etiopathogenetic factors of AA were: the most common intra-abdominal hemorrhage in 68.14%, followed by inflammation and the most common complications of pelvic inflammatory disease in 25.60%, ischemic-obstructive causes in 2.56% and other causes in 3.7%. Out of the total number of surgeries, 450 (64.01%) were due to ectopic tubal pregnancy. Out of the total number of surgeries, 549 (78.09%) were performed (completed) by laparoscopy procedures, and by laparotomy and/or relaparotomy in 154 cases (21.90%). Regarding laparoscopy, 93.48% was performed in the age group up to 20 years, 83.56% in the age group of 21–45 years, and 62.26% was performed in the age group of 46–52 years. Regarding laparotomy, 69.57% was performed in patients aged 53–60 years, and 100% in the age group of patients >60 years. A pathological substrate was found for all operated patients, which they undergo for surgery, and we had no cases in which we did not prove a perioperative or pathohistological reason for AA. There were no patients’ deaths in the current study, which had to undergo for surgery for AA. Conclusions: We emphasize the urgent need for proper and continuous education of hospital teams, as well as extra-hospital emergency teams in recognizing AA symptoms of gynecological genesis based on history, clinical palpation examination, and ultrasound examination as a fundamental triad in the diagnosis of this life-threatening condition that requires only surgical treatment.
Potential Role of GLP-1 Based Therapeutics in Coronary Artery Disease
Authors: Xiong Qianfeng , Wang Jing , Huang Kewen , Li Wenbo , Zhang Lihui
Published: December 2023

Glucagon-like peptide-1 (GLP-1), an incretin hormone primarily secreted by intestinal L cells, regulates glucose metabolism by increasing insulin synthesis and secretion, decreasing plasma glucagon levels, reducing food intake, and slowing gastric emptying. This has led to the development of GLP-1 receptor (GLP-1R) agonists as a treatment for diabetes and obesity. In addition to being present in beta cells, GLP-1R has also been identified in blood vessels and the heart, suggesting that GLP-1R agonists may have an impact on cardiovascular health. There is now substantial evidence supporting GLP-1’s protective effects on the cardiovascular system. This review summarizes the current research on GLP-1-based therapy for coronary artery disease (CAD) by examining its protective effects against inflammation and ischemia/reperfusion injury and analyzing clinical trials on GLP-1-based therapies for CAD. Although results from various studies were inconsistent, the challenge of transitioning GLP-1-based therapies from the laboratory to the clinical setting remains. Further well-designed and high-quality studies are necessary to determine the efficacy and safety of GLP-1 for patients with CAD.
MicroRNA in Fibrotic Disorders: A Potential Target for Future Therapeutics
Authors: Mehjabin Aanushka , Kabir Maliha , Micolucci Luigina , Akhtar Most Mauluda , Mollah A. K. M. Moniruzzaman , Islam Md Soriful
Published: December 2023

Fibrotic disorders are defined by accumulating excessive extracellular matrix (ECM) components, especially collagens, in various organs, leading to tissue scarring and organ dysfunction. These conditions are associated with significant challenges in the healthcare system because of their progressive nature and limited treatment options. MicroRNAs (miRNAs) are small non-coding RNA molecules (approximately 22 nucleotides) that modulate gene expression by selectively targeting mRNAs for degradation or translational repression. MiRNAs have recently been identified as potential targets for therapeutic developments in fibrotic disorders. They play vital roles in inducing fibrotic phenotype by regulating fibroblast activation and ECM remodeling. Multiple strategies for targeting specific miRNAs in fibrotic disorders have been explored, including antisense oligonucleotides, small molecule modulators, and natural compounds. This review discussed the role of miRNAs in different fibrotic disorders, including cardiac fibrosis, liver fibrosis, kidney fibrosis, lung fibrosis, dermal fibrosis, and primary myelofibrosis, with recent advances in developing miRNA-based therapeutics.
MicroRNA-599-Regulated Susceptibility to Acute Kidney Injury in Patients with Cirrhosis is Mediated by the Sirtuin 1 (SIRT1) rs4746720 Single Nucleotide Polymorphism
Authors: Zhou Fangfang , Chen Yixin , Xu Youjun , Luo Qun
Published: December 2023

Objective: The aim of this case-control study was to analyze the association between sirtuin 1 (SIRT1) single nucleotide polymorphism (SNP) and the risk of acute kidney injury (AKI) in Han Chinese patients with cirrhosis and to explore its potential mechanism. Methods: Twenty-nine AKI patients with cirrhosis (AKI group) and 87 non-AKI patients with cirrhosis (control group) were recruited from a Han Chinese population. SNaPshot sequencing technology was used for the detection of SNPs. Dual luciferase reporter vectors were constructed and co-transfected into HK-2 human proximal tubular epithelial cells. SIRT1-overexpressing recombinant plasmids were constructed and co-transfected into HK-2 cells. The expression of microRNA-599 (miR-599) and SIRT1/peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC-1α)/nuclear respiratory factor 1 (NRF1)/mitochondrial transcription factor A (TFAM) was detected by the quantitative polymerase chain reaction, and the expression of the corresponding proteins was detected by Western blotting. Results: There were no statistically significant between-group differences in the genotype and allele frequencies of SIRT1 rs4746720. In the subgroup of patients with hepatic encephalopathy, the SIRT1 rs4746720 SNP was significantly associated with the development of AKI, and the risk of AKI in patients with the T allele was six times higher than in those with the C allele. The results of the in vitro experiments demonstrated that the T allele of SIRT1 rs4746720 increased the binding of miR-599 to the rs4746720 locus within the 3′-UTR of SIRT1 (p < 0.001). The results of the SIRT1-overexpressing recombinant plasmid experiments confirmed that the T allele of SIRT1 rs4746720 mediated the binding of miR-599, leading to decreased SIRT1 and PGC-1α, NRF1, and TFAM (p < 0.05). Conclusions: The SIRT1 rs4746720 SNP might be linked with AKI in cirrhotic patients, and the T allele increased the risk of AKI in those with hepatic encephalopathy. The rs4746720 SNP in the SIRT1 3′-UTR is linked to the development of AKI in cirrhotic patients with hepatic encephalopathy, potentially by mediating the binding of miR-599.
EGCG Restores Keratinocyte Autophagy to Promote Diabetic Wound Healing through the AMPK/ULK1 Pathway
Authors: Tian Chao , Feng Yuchao , Chen Tianhua , Zhang Zuyang , He Xiaojie , Jiang Liangdong , Liu Mingjiang
Published: December 2023

Background: Delayed wound healing, a common problem in patients with diabetes mellitus (DM), is associated with impaired keratinocyte autophagy. Epigallocatechin gallate (EGCG), a catechin, has been proven to promote diabetic wound healing. This study aims to explore the therapeutic mechanism of EGCG on diabetic wound healing. Methods: High glucose (HG)-induced keratinocytes and streptozotocin (STZ)-induced DM rats were prepared and intervened with EGCG to examine its therapeutic effects in in vivo and in vitro settings. The AMPK inhibitor, Compound C, was utilized to determine whether EGCG exerted its therapeutic effects through the AMPK/ULK1 pathway. Results: In vitro, EGCG improved HG-induced autophagy impairment in keratinocytes by increasing LC3II/LC3I, Becline1, and ATG5 levels and decreasing p62 level. Mechanically, EGCG activated the AMPK/ULK1 pathway, thereby promoting keratinocyte autophagy through the phosphorylation of AMPK and ULK1. Notably, EGCG promoted the proliferation, migration, synthesis and release of C-C motif chemokine ligand 2 (CCL2) in HG-treated keratinocytes. Furthermore, EGCG indirectly promoted the activation of fibroblasts, as evidenced by increased alpha-smooth muscle actin (α-SMA) and Collagen I levels. In vivo, EGCG promoted wound healing in DM rats, primarily by reducing inflammatory infiltration and increasing granulation tissue to promote wound epithelialization. Besides, EGCG promoted ATG5, KRT10, KRT14, TGF-β1, Collagen I, and α-SMA expressions in the neonatal epithelial tissues of DM rats. However, the use of Compound C reversed the effects of EGCG. Conclusions: These findings indicated that EGCG restored keratinocyte autophagy to promote diabetic wound healing through the AMPK/ULK1 pathway.
Anti-Inflammatory Effects of Chaenomeles sinensis Extract in an ALS Animal Model
Authors: Yang Eun Jin , Lee Sun Hwa
Published: December 2023

Background: Amyotrophic lateral sclerosis (ALS) is a systemic disease with multiple pathological effects, including neuroinflammation, oxidative stress, autophagy, mitochondrial dysfunction, and endoplasmic reticulum stress. Despite many studies seeking to identify and develop effective therapies, effective ALS treatment has yet to be approved. Hence, patients with ALS ultimately experience muscle atrophy and loss of motor neurons. Herbal medicines have been used to treat numerous diseases by modulating multiple biological processes and exerting pharmacological effects, including anti-inflammatory and antioxidant properties. In particular, Chaenomeles sinensis Koehne (CS) exhibits anti-hyperuricemic and nephroprotective effects and is used to treat anaphylaxis, viral infections, and neurodegenerative diseases, such as Alzheimer’s disease. This study monitored the effects of CS supplementation on muscle function and motor neurons in hSOD1G93A mice, an established ALS animal model. Methods: Body weight measurements and behavioral tests were performed; additionally, western blotting and immunohistochemistry analyses were conducted using the mice gastrocnemius, tibialis anterior, and spinal cord. Results: CS augmented anti-inflammatory and antioxidant effects in the muscle and spinal cord of hSOD1G93A mice. Furthermore, CS improved motor function and regulated autophagy in the muscles of the hSOD1G93A mice. Conclusions: CS might represent a promising supplement for improving motor function and delaying ALS progression. However, its development for clinical use warrants further investigation.
Clinical Effectiveness and Safety Comparison between Reduced Rivaroxaban Dose and Dual Antiplatelet Therapy for Nonvalvular Atrial Fibrillation Patients Following Percutaneous Left Atrial Appendage Closure: A Prospective Observational Study
Authors: Li Xiaoye , Jin Qinchun , Yao Yao , Zhang Xiaochun , Lv Qianzhou
Published: December 2023

Background: Device-related thrombosis (DRT) after successful closure implantation on left atrial appendage (LAA) was considered as a major challenge and optimal strategy on antithrombotic therapy remains to be solved. This study was performed to compare the clinical effectiveness and safety of reduced rivaroxaban dose (RRD) and dual antiplatelet therapy (DAPT) after left atrial appendage closure (LAAC) implantation with the Watchman device. Methods: After successful LAAC, consecutive participants were medicated with a standard DAPT or RRD. The primary endpoints included DRT, thrombosis events (TE), and bleeding events that were documented during a 12-month follow-up period. Results: 767 patients (DAPT: n = 140; RRD: n = 627) were initially included. After propensity score matching (PSM), 140 patients treated with DAPT and 280 patients with RRD were included in each group with similar baseline information, thromboembolic and bleeding risk factors, cardiovascular risk factors and concomitant medication. In the RRD group, 193 patients were on rivaroxaban 15 mg (R15) and 47 received rivaroxaban 10 mg (R10). The incidence of DRT was documented in 12 (9.3%) patients in the DAPT group and 3 (6.3%) in R10 and 7 (3.0%) in R15 (log-rank p = 0.050). DAPT subgroups were more likely to experience shorter time to DRT as compared to R15 (R15 vs. DAPT hazard ratio (HR) = 0.334, p = 0.015, 95% CI: 0.131–0.850). The median length of DRT in the R15 group was significantly lower than that of the DAPT group (1.721 [1.610–1.818] mm vs. 1.820 [1.725–1.925] mm, p = 0.029). Compared with the unadjusted estimated rates of ischemic events for patients with similar congestive heart failure, hypertension, age ≥75 years, diabetes mellitus, prior stroke or transient ischemic attack or thromboembolism, vascular disease, age 65–74 years, sex category (CHA2DS2-VASc) scores, a significant decrease of 68.6% in ischemic stroke rates was noted in the R15 group, which contributed to a 54.9% reduction of overall thromboembolic events. The overall minor bleeding was not significantly different amongst the three groups (p = 0.944). Procedural bleeding was more common in the DAPT group, as compared with the R10 and R15 groups. Conclusions: After successful closure implantation, long-term RRD significantly reduced the DRT and TE occurrence compared with DAPT.
The city as a culture-forming concept of the frontier
Authors: Vagabov Makhach , Gazieva Abidat , Khanbalaeva Sabina
Published: December 2023

In accordance with the theory of frontier zones, the article examines the formation and development of the cultural type of the Caucasian frontier. The authors note the fortress cities as the main space for the formation and spread of the frontier type of culture. Due to the heterogeneous space of the frontier as a whole, the polyethnic and polyconfessional environment of the urban space, a model of tolerant attitudes of the frontier and susceptibility to acculturation phenomena is being formed.
Penerapan Berpikir Kritis Pada Pembelajaran Siswa
Authors: Ryadi Rifky Aryaputra
Published: December 2023

Penulisan artikel ini berdasarkan hasil pengamatan penulis melalui lingkungan sekitar. Tujuan penulisan artikel ini yaitu untuk menggambarkan bahwasanya pola pikir pada ranah sekolah masih dalam kata jauh atau tidak sampai menerapkan berpikir kritis. Faktor dari hal ini berasal dari berbagai faktor, baik dari internal atau eksternal, salah satu faktor terbesar yaitu teori yang diberikan. Dalam mengatasi masalah ini tentu ada banyak caranya, namun peran guru dalam hal ini sangat berpengaruh, sehingga penerapan pola ini dapat berkembang dan menjadi bekal pada jenjang pendidikan yang lebih tinggi.
Digital Entrepreneurs and Business Planning: Intentions and Linkages
Authors: Harlieanto Jery
Published: December 2023

A business plan is the basis for creating a business for digital entrepreneurs. The availabilityof online media or online platforms helps digital entrepreneurs do business more easily butwith greater risks. With all the pros and cons, being a digital entrepreneur we will still becarried away by developments in the era that are increasingly digitalizing our lives, so we areobliged to adapt.
Green Entrepreneur in Business Plan: Regulatory, Innovation and Responsibility Approach
Authors: khoe olivia valencie
Published: December 2023

Studi kewirausahaan hijau (green entrepreneur) di seluruh dunia terus meningkat. Green entrepreneur mengacu pada individu atau organisasi yang menciptakan atau mengembangkan produk atau layanan yang ramah lingkungan. Tujuan utama mereka adalah untuk mengurangi dampak negatif terhadap lingkungan, baik melalui penggunaan bahan-bahan yang berkelanjutan, teknologi yang ramah lingkungan, atau praktik bisnis yang mengutamakan keberlanjutan (Purnomo et al., 2023). Sistem pengambilan keputusan berguna bagi para pengusaha hijau (Irawan et al., 2023). Kombinasi kewirausahaan hijau dan kewirausahaan berkualitas tinggi dengan memperkenalkan orientasi lingkungan sebagai karakteristik kualitas start-up yang belum dikenal dan tiga dimensi kualitas yaitu inovasi, orientasi pertumbuhan, dan orientasi internasional. Literatur kewirausahaan berpendapat bahwa hanya perusahaan rintisan berkualitas tinggi yang berkontribusi terhadap pembangunan berkelanjutan dan diperlukan pemahaman yang lebih baik tentang apa yang menentukan kualitas perusahaan rintisan. Penelitian empiris baru-baru ini menunjukkan bahwa orientasi lingkungan dari perusahaan rintisan (start-up) merupakan salah satu faktor penentu, karena orientasi lingkungan secara signifikan memprediksi inovasi mereka. Makalah ini menelusuri jalur penelitian baru tentang pentingnya orientasi lingkungan untuk kualitas start-up dalam dua cara. Pertama, makalah ini mengevaluasi dan memperluas bukti awal mengenai orientasi lingkungan dan inovasi dengan memeriksa sampel tiga kali lebih besar, yang mencakup negara-negara tambahan dan tahapan kewirausahaan. Kedua, tulisan ini juga menganalisis dampak orientasi lingkungan terhadap dimensi kualitas orientasi pertumbuhan dan orientasi internasional. Investigasi menggunakan data Global Entrepreneurship Monitor terhadap 9.650 pengusaha dari 51 negara mengungkapkan bahwa start-up dengan orientasi lingkungan yang lebih tinggi memiliki kualitas unggul dalam hal inovasi, ekspektasi pertumbuhan, dan ekspor. Hasil ini tetap kuat untuk start-up pada tahap kewirausahaan yang berbeda, dan pengujian yang menggunakan pendekatan metodologi dan definisi variabel yang berbeda (Neumann, 2023).