bluuebunny/crossref_metadata_2025 huggingface dataset:
Mental Disorder as an Illness: Szasz Revisited
Authors: Bamijoko-Okungbaye Abiola
Published: April 2023

Thomas Szasz was a psychiatrist with great intellectual sagacity, consistent and unwavering with his concept of mental illness. He famously argues that mental illness is a myth. If Szasz's arguments are prima facie propositions and mental health interventions are considered myth-making endeavors, psychopharmacological engagement during treatment might be the most unjustified coercion of this generation. For Szasz, mental disorders are in the realm of psycho-social-ethical-legal. He views the existing treatment model of mental illness as an ideological validation of coercion. This tension in his findings stems from two angles, the exclusion of bodily illness dynamics that is currently unknown and extreme activities that are not considered illnesses. Call this the value-ladenness of the mental disorder proposition.
I maintain that this proposition fails to show the polythetic nature of mental disorders. Specifically, I aver that the value-ladenness proposition on which his theory is predicated requires that we deny the emergent anatomical-physiological factual norms that plausibly can exist, namely knowledge of brain structures and functions in neuroscience. I claim that such knowledge can emerge. Howbeit, Szasz's framework is partially valid when he admits the psychosocial features of mental disorders due to the value-ladenness of mental disorders. I will consolidate this partial validity with a position accordant with realist philosophy drawing from Foucault, Fulford, and Kendell solidified by the evidence of cognitive-affective science within the domain of contemporary ampliative understanding of mental conditions to answer the questions raised by Szasz's proposition.
Adrenergic and cholinergic innervation of tumor-like formations of vocal folds in patients with autonomic disorders
Authors:   Saint Petersburg Research Institute of Ear, Throat, Nose and Speech,  Saint Petersburg, 190013, Russia, Shustova T. I.
Published: April 2023

To develop therapeutic measures aimed at improving the voice and including exposure to specific mechanisms of the autonomic nervous system (ANS), it is necessary to know the features of the autonomic innervation of the vocal folds, which has a significant impact on the work of the vocal apparatus by regulating the trophic state of the elements forming it. Objective. Histochemical detection of adrenergic and cholinergic nerve fibers in tumor-like formations of vocal folds in patients with autonomic disorders. Materials and methods. A comprehensive examination of 64 patients with impaired voice function was carried out. During the examination, the medical history was studied, an objective examination of the upper respiratory tract according to generally accepted methods and with the help of video stroboscopic instrumentation, a cytological examination of touch preparation from the affected laryngeal area, and a study of the functional state of the ANS from the surgical material, including histological and histochemical examination of the removed tissue, were carried out. As a result, all patients were clinically diagnosed with a vocal fold polyp. Results. Histological, histochemical, and cytological studies have shown that in 80% of patients morphofunctional alterations of the vocal folds were combined with inadequate autonomic maintenance of activity. The data obtained allow us to assume that hyperplastic compensatory and adaptive responses of the laryngeal mucosa pass to pathological dystrophic changes and may contribute to deviations of the mucosal epithelium from normal histological differentiation toward atypia. Such changes create conditions for the development of benign and malignant tumors. Conclusion. In general, the data obtained give reason to believe that with prolonged dysfunction of the ANS a neurodystrophic process develops in the body, taking part in the pathogenesis of various diseases, including diseases of the larynx. With this in mind when performing preventive and therapeutic measures aimed at patients with tumor-like formations of the vocal folds, it is necessary to assess the functional state of the ANS and include measures to correct autonomic parameters in the general treatment and rehabilitation regimen.
Removal of partial atretic plate with isolated middle ear anomaly
Authors:   Saint Petersburg Research Institute of Ear, Throat, Nose and Speech,  Saint Petersburg, 190013, Russia, Anikin I. A. , Komarov M. V. ,   Saint Petersburg Research Institute of Ear, Throat, Nose and Speech,  Saint Petersburg, 190013, Russia,   City Hospital N 26, Saint Petersburg, 196247, Russia,   Mechnikov Northwest State Medical University, Saint Petersburg, 191015, Russia, Goncharov O. I. ,   City Hospital N 26, Saint Petersburg, 196247, Russia
Published: April 2023

Congenital isolated anomalies of the development of the middle ear arising from a violation of embryogenesis occur in approximately 1 in 10,000–15,000 newborns and can cause significant hearing loss from the abnormal ear, leading to a delay in psycho-speech development. In particular, one of the rare isolated anomalies of the middle ear is a partial atretic plate, the probability of its occurrence has not been specified. Unlike the full atretic plate, the partial plate is thinner and partially blocks the entrance to the tympanic cavity from the side of the external auditory canal. In this article, based on the observations, we present the identified pattern of development of partial atretic plates relative to their location. The first option is tympanosquamous, in which the plate originates from sutura tympano-squamosa; the second is the tympanicmastoidea variant, in which it is determined in the area sutura tympano-mastoidea. A developed method for the surgical treatment of isolated anomalies with partial atretic plates, with the preservation of the fibrous layer, the creation of a neoannulus by forming a circular bone groove, which made it possible to solve the main problems in the treatment of this malformation, is presented. The aim of the study of this work was to increase the effectiveness of surgical treatment of patients with anomalies in the development of the ear accompanied by the presence of a partial atretic plate. From 2009 to 2018, 16 surgical interventions (16 patients, 16 ears) were performed at the Saint Petersburg Research Institute of Ear, Throat, Nose, and Speech for isolated anomalies in the development of the middle ear with the presence of a partial atretic plate. As a result of the study, it was determined that the method of preserving the ossicular chain, even considering its intraoperative mobilization, did not prove to be the best method of treatment due to a pronounced increase in the air-bone gap in the first months after surgery, which is due to refixation of the incus body and the malleus head in attica. The developed method for the removal of partial atretic plates in isolated congenital anomalies in the development of the middle ear has shown its high effectiveness in assessing long-term anatomical and functional results.
Twenty-ninth International Conference on Learning. Conference Proceedings
Authors: Kalantzis Mary , Ortega Martín José Luis
Published: April 2023

Proceedings of the Twenty-ninth International Conference on Learning, hosted by the University of Valencia, July 13 - 15, 2023. The conference featured research addressing the following special focus: “Intercultural Learning in Plurilingual Contexts” and annual themes: Pedagogy and Curriculum; Assessment and Evaluation; Educational Organization and Leadership; Early Childhood Learning; Learning in Higher Education; Adult, Community, and Professional Learning; Learner Diversity and Identities; Technologies in Learning; Literacies Learning; Science, Mathematics and Technology Learning.
Freud's Emissaries: the transfer of psychoanalysis through the Polish intelligentsia to Europe 1900-1939
Authors: Magnone Lena
Published: April 2023

Aiming to recount how psychoanalysis reached the Polish intelligentsia in the first decades of the twentieth century, this books follows the life trajectories of a few Polish-Jewish disciples of Freud who played a significant role in this process: Ludwig Jekels, Helene Deutsch, Beata Rank, Eugenia Sokolnicka, Gustav Bychowski, Zygfryd Bernfeld, the sisters Berta and Stefania Bornstein, and a handful of other individuals. None of them were born in Poland – the state had disappeared from Europe’s map at the end of the eighteenth century, when, in three successive partitions, the territory of the former Polish-Lithuanian Commonwealth was divided between the Kingdom of Prussia, the Habsburg Empire and the Russian Tsarist Empire. Only one of these protagonists became a citizen of the Second Polish Republic when it was created in 1918. Some were key to the transfer of Freudian thought to other countries, such as Sweden or France. Most left Europe in the 1930s and established themselves in the United States, contributing to the postwar cultural success of psychoanalysis. It is thus a narrative of Jewish migrations and, to the same extent, a reflection on traveling concepts. The book follows its protagonists in their upward social mobility and subsequent exile and uprooting. It also examines how a subversive emancipatory idea born in the turmoil of fin-de-siècle Vienna transformed into an American therapeutic method, deprived of all political scope
Comunidades patrimoniales como articuladoras y conservadoras de la cultura maya: el Centro Comunitario Uj-Ja’ Síijo’ob de Canicab (Yucatán, México)
Authors: Luna Ursula , Mijangos Noh Juan Carlos , Portolés Gorriz Ángel , Ibáñez-Etxeberria Álex
Published: April 2023

En las últimas décadas las comunidades patrimoniales se han convertido en conservadoras y transmisoras de los patrimonios que han estado en peligro de desaparición, donde acciones colectivas han sido destinadas a la preservación de elementos patrimoniales en situación de desamparo. En este trabajo se recoge el nacimiento y desarrollo de las actividades desarrolladas en el Centro Comunitario Uj-ja’ Síijo’ob de Canicab, Yucatán, desde su inauguración en el año 2012 hasta la actualidad. Este proyecto surge unido a un grupo de voluntarios, pretendiendo ser un espacio de alfabetización de niños y adultos en primera instancia, para acabar siendo un espacio de diálogo abierto a toda la comunidad, en el que el patrimonio y la educación son los dos ejes clave. De este modo, se muestra un ejemplo del valor de las comunidades patrimoniales en la preservación y transmisión del patrimonio cultural maya en México.
A estética decolonial no ativismo de coletivos teresinenses
Authors: Coimbra Kary Emanuelle Reis
Published: April 2023

In this work we analyze how the aesthetic expression of collectives in the city of Teresina (Piaui, Brazil) is related to the decolonial argument, especially from the perspective of the intellectuals of Modernity-Coloniality Group. A qualitative field research was carried out with collective formations from Teresina, based on the apprehension of interviews with their members, in focus group sessions; and the selection of posts on their social media Facebook and Instagram. The data were interpreted by the method of Critical Discourse Analysis, in the Faircloughian dialectical-relational aspect. The results showed that these groups represent an important face of contemporary activism, as they evoke sensations and perception processes that dialogue with diversity. In this sense, we conclude that clothing, artifacts, and corporeities/performances are used to offer visibility to groups socially excluded by the colonial-modern logic, awakening other sensations and perceptions about the standardization and universalization of ways of being and living.
Sob o peso das asas: considerações sobre os putti do retrato "Willem Van Den Kerckhoven e sua família" (1652) de Jan Mijtens (Haia ca. 1614-1670)
Authors:   Universidade Federal do Rio de Janeiro, Carvalho Alcimar do Lago
Published: April 2023

As populações pré-industriais da Europa Ocidental apresentaram taxas de mortalidade infantil e pós-infantil extremamente altas (Vries 1991, p. 263). Famílias pobres ou ricas habitualmente perdiam seus filhos desde o nascimento ou ainda nos primeiros dias de vida, devido a malformações congênitas e partos difíceis, mas principalmente na primeira infância, vitimados por doenças, infecções e epidemias (Morel 2004, p. 16). Fomes, guerras e pestes diminuíram tanto a qualidade de vida no norte da Europa no início do período Moderno, que acabaram por reduzir a expectativa de vida no nascimento a apenas 28,4 anos (Vries 1991, p. 263). Sabemos que nos Países Baixos a mortalidade infantil no século XVII foi significantemente maior que no século anterior, particularmente entre 1600 e 1650, comprometendo a própria existência de inúmeras famílias de nobres (Nierop 1993, p. 64). Somente a partir do final do século XVII passa a ocorrer um aumento da expectativa de vida na Europa em geral, correlacionado ao aumento da produtividade agrícola, mas principalmente conexo com a diminuição da virulência de algumas doenças, o desaparecimento virtual da peste bubônica e o desenvolvimento dos primeiros tratamentos de combate a doenças infecciosas como a varíola (Cain & Patterson 2012, p. 76).
Tratamiento lexicográfico de zoónimos y fitónimos en diccionarios de colombianismos
Authors: Astrid Ciro Lirian
Published: April 2023

The purpose of this article is to investigate the lexicographic treatment of zoonyms and phytonyms in differential dictionaries, by taking into account the descriptive approach. Moreover, the microstructure of lexicographic articles of these lexical contents is analyzed in seven dictionaries of Colombianisms with the objective of providing a general overview of the lexicographic representation of these units, as well as an approach to the evolution of their treatment in lexical repertoires of regionalisms. In addition, the pending tasks regarding zoonyms and phytonyms study and analysis in dialectal lexicography is presented.
The Evolution of Calpurnia Tate (2009) y su traducción al español. Aprendizaje científico en femenino
Authors: Rodríguez Rodríguez Beatriz Mª
Published: April 2023

This paper analyses the young adult novel The Evolution of Calpurnia Tate (2009) by Jacqueline Kelly, and its translation into Spanish. From a feminist approach, it will be studied whether references criticising gender inequality have been maintained or even highlighted (von Flow, 1991). The implementation of Marco Borillo’s functional analysis (2001) and Brunette’s assessment criteria (2000) will enable us to conclude that not all nuances have been respected in certain translation strategies. This fact results in slightly modifying the writer’s intention, which does not seem really correct as the novel introduces the evolution of a brave girl who wants to become a female scientist in 1899, and who does not understand traditional social conventions.
Resiliencia y alumnado de español L2 en contextos migratorios
Authors: Salido Machado Elena
Published: April 2023

Resilience has emerged as an individual skill and a social value due to dramatically increasing social inequality, becoming extremely popular in academic contexts and more recently in SSL teaching. This article intends to analyze resilience origin and its use in educational literature, characterize the concept resilient subject and detect the implications of its use by using neoliberal logic to define the discourses of resilience and their effects in the L2 Spanish classroom using a decolonial feminist approach through the concept of “colonial/modern gender system” in neoliberal nation-states. Results show that resilience present in educational literature is framed within neoliberal paradigm perpetuating unequal power relations.
Natàlia Romaní, La historia de la nostalgia
Authors: Cittadini Lorenzo
Published: April 2023

Natàlia Romaní, La historia de la nostalgia. Trad. by Andrés Prieto. Barcelona: Catedral, 2021. 465 pages. ISBN: 978-84-18059-68-1.
VOLCANOES IN MOTION: EL HIERRO AND LA PALMA.
Authors: Pérez Torrado Francisco José , Rodríguez González Alejandro , Moreno Medina Claudio , Cabrera Santana María del Carmen , Carracedo Gómez Juan Carlos , Díaz Rodríguez Santiago , Fernández-Turiel José-Luis , Criado Hernández Constantino , Aulinas Juncá Meritxell , Prieto-Torrell Claudia
Published: April 2023

We explain, through a collection of ten panels distribuited in five thematic blocks, the geological history of the El Hierro and La Palma islands in the framework of intraplate volcanic islands evolution. In the first two panels we explain how the Canary Islands were formed and evolved, and the birth of El Hierro, the youngest island of the archipelago. Next, we observe the landscapes of El Hierro as a response to macro-scale, such as giant landslides and rifts, and micro-scale phenomena (volcanic cones, lava fields and shore platforms). The last eruption of the El Hierro island in 2011-12 that gave rise to the Tagoro submarine volcano is also exposed. In addition, we present how the Herreños have adapted to the territory, knowing how to take advantage of its scarce water resources and adapt their way of life to the volcanic landscape, achieving that the entire island was declared in 2000 a UNESCO World Biosphere Reserve and Geopark in 2015. In the last two panels we expose the geological evolution of the island of La Palma and its last eruption of the Tajogaite volcano in 2021. THEMATIC BLOCK I. A SEA OF VOLCANOES:“Origin of the Canary islands”, “And El Hierro was born”. THEMATIC BLOCK II. VOLCANIC LANDSCAPES:"Megaestructures", “Structures on the ground”. THEMATIC BLOCK III. EXPLORE THE VOLCANIC PARADISE:“Walking among volcanoes”, "The last volcano of El Hierro" THEMATIC BLOCK IV. LIVING AMONG VOLCANOES:"The water in El Hierro",“What the land tell us” THEMATIC BLOCK V. LA PALMA: THE PRETTY ISLAND: "And La Palma was born",“The 2021 eruption”.
Negotiating food heritage authenticity in consumer culture
Authors: Shahrin Nurzawani , Hussin Hanafi
Published: April 2023

Purpose – Food has entered commerce as an intangible cultural heritage (ICH) because consumers want authentic food and memorable consumption experiences. Food culture and the marketplace are arenas for the creation and articulation of identities and meanings, enabling dynamic conditions that encompass multiple positions and authenticity validations in consumption experiences. This study offers insight into the authentication of gastronomic heritage from a consumer culture perspective. Design / Methodology – A thematic review is conducted to analyse and summarise the literature on gastronomic heritage, authenticity, commercialization, and consumer behaviour in the food industry. Approach – Literature works from databases and academic platforms were used to highlight several key thematic points and arguments related to the authentication process and consumer behaviour. Findings – Food authenticity is socially negotiated by a variety of actors who mobilise resources and a web of interactions, creating identity and value according to their position as they respond to differences in market culture. The negotiation of authenticity mediates the assumption of legitimacy, quality, and identity that diversifies consumption patterns. Originality of the research – The article contributes to a theoretical discourse that extends the conceptualisation of authenticity in addressing food heritage within a dynamic consumption context and commercialisation agenda.
Multivariate soft sensor for product monitoring in the debutanizer column with deep learning
Authors: Rosyadi Imron , Wardhana Arief Wisnu , Aliim Muhammad Syaiful , Ediati Rifah , Ristiawan D
Published: April 2023

Soft sensors have been proposed extensively for predicting ill-to-measure variables in industrial processes. In this study, we developed a multivariate soft sensor for debutanizer columns. A soft sensor was proposed to replace the chromatograph-based butane content from the debutanizer column. Recently, deep learning methods have been implemented for better feature representation of complex systems. We developed an LSTM-based multivariate soft sensor that can better represent the dynamics of a debutanizer column system. Our results show that the univariate LSTM soft sensor performs better than previously proposed methods.
The External, Internal Factor and Ecosystem Services to Support Mangrove Rehabilitation Planning in North Coast of Jakarta
Authors: Hilmi Endang , Usman Uus , Iqbal Achmad
Published: April 2023

The mangrove ecosystem on North Coast of Jakarta has many services and function both of ecology, social and economic function and services, including the tidal flooding reduction, land subsidence reduction, pollution reduction, ecotourism and others. However, the mangrove ecosystem in North Coast of Jakarta Mangroves are being badly damaged, so require effort and activity to rehabilitate. This research aimed to develop  rehabilitation strategy of mangrove ecosystem in North Coast of Jakarta to reduce coastal disaster and to support ecosystem services. The methods of this research used IFAS, EFAS analysis and Buchard analysis. The results showed that the ecosystem services of mangrove ecosystem were are ecotourism, conservation, wildlife reserves, reduction of tidal flooding, abrasion and accretion, reduction of intrusion, reduction of land subsidence, economic income, fishing and fishpond activities, pond activities, and social benefits. The strategy of mangrove rehabilitation was weakness-opportunity strategy (minimalizing weakness,  taking advantage of opportunities, and avoid threats. The strategies of mangrove rehabilitation plaaning were mangrove rehabilitation, mangrove revitalization, support creative economy, developing greenbelt, increasing human resources and developing blue carbon
Adhesive and Rheological Features of Ecofriendly Coatings with Antifouling Properties
Authors: Scolaro Cristina , Liotta Leonarda F. , Calabrese Carla , Marci Giuseppe , Visco Annamaria
Published: April 2023

in this work formulations of "environmentally compatible" silicone-based antifouling synthesized in the laboratory and based on copper and silver on silica/titania oxides have been characterized, capable of replacing the non-ecological antifouling paints currently on the market. The texture properties and the morphological analysis of these powders with an antifouling action indicate that their activity is linked to the nanometric size of the particles and to the homogeneous dispersion of the metal on the substrate. The presence of two metal species on the same support limits the for-mation of nanometric species and therefore the formation of homogeneous compounds. The presence of the antifouling filler (specifically the one based on TiO2 and Ag) facilitates the achievement of a higher degree of cross-linking of the pure resin, and therefore a better compactness and completeness of the coating. This leads to a consequent better degree of adhesion to the tie-coat and therefore to the steel support used for the construction of the boats.
Synthesis and Characterization of Tetraphenylethene AIEgen-Based Push-Pull Chromophores for Photothermal Applications: Do the Cycloaddition – Retroelectrocyclization Click Reaction Could Make any Molecule Photothermally Active?
Authors: Roger Maxime , Bretonnière Yann , Trolez Yann , Vacher Antoine , Arbouch Imane , Cornil Jérôme , Félix Gautier , Winter Julien De , Richeter Sébastien , Clément Sébastien , Gerbier Philippe
Published: April 2023

Three new tetraphenylethene (TPE) push-pull chromophores exhibiting strong intramolecular charge transfer (ICT) are described. They were obtained via [2+2] cycloaddition - retroelectrocyclization (CA-RE) click reactions on an electron-rich alkyne-tetrafunctionalized TPE (TPE-alkyne) using both 1,1,2,2-tetracyanoethene (TCNE), 7,7,8,8-tetracyanoquinodimethane (TCNQ) and 2,3,5,6-tetrafluoro-7,7,8,8-tetracyanoquinodimethane (F4-TCNQ) as electron-deficient alkene. Only the starting TPE-alkyne displayed a significant AIE behavior, whereas for TPE-TCNE,a faint effect was observed and for TPE-TCNQ and TPE-F4-TCNQ, no fluorescence was observed in any conditions. The main ICT bands that dominate the UV-Visible absorption spectra underwent a pronounced red-shift beyond the near-infrared (NIR) region for TPE-F4-TCNQ. Based on TD-DFT calculations, it was shown that the ICT character shown by the compounds exclusively originated from the clicked moieties independently of the nature of the central molecular platform. Photothermal (PT) studies conducted on both TPE-TCNQ and TPE-F4-TCNQ in the solid state revealed excellent properties, especially for TPE-F4-TCNQ. These results indicated that CA-RE reaction of TCNQ or F4-TCNQ with donor-substituted are promising candidates for PT applications.
gRNA Design: How its Evolution Impacted on CRISPR/Cas9 Systems Refinement
Authors: Motoche-Monar Cristofer , Ordoñez Julian E , Chang Oscar , Gonzales-Zubiate Fernando A
Published: April 2023

In the last decade, the genetic engineering world has been shaken up by a relatively new genetic editing tool based on RNA-guided Nucleases (RGNs): the CRISPR/Cas9 system. Since the first report in 1987 and its characterization in 2007 as a bacterial defense mechanism, the interest and research on this system have grown exponentially. CRISPR systems provide immunity to bacteria against invading genetic material; however, with specific modifications in sequence and structure, it becomes a precise editing system that makes it possible to genetically modify almost any organism. There are diverse approaches regarding the refinement of these modifications, such as constructing more accurate nucleases, understanding the cellular context and facing the epigenetic conditions, or re-designing guide RNAs (gRNAs). Considering the critical importance for the correct CRISPR/Cas9 systems performance, our scope will emphasize in the latter approach. Hence, we present an overview of the past and the most recent guide RNA web-based design tools, highlighting their computational architecture and gRNA characteristics evolution through the years. Our study concisely explains the computational approaches that use machine learning techniques, deep neural networks, and large datasets of gRNA/target interactions to make possible both predictions and classifications directed to design, optimize, and create promising gRNAs suitable for future gene therapies.
Prevalence of Active Primitive Reflexes and Craniosacral Blocks in Apparently Healthy Children and Relationships With Neuro-Development Disturbances
Authors: León-Bravo Gema , Cantarero-Carmona Irene , Caballero-Villarraso Javier
Published: April 2023

Background: In healthy children, the frequency of anomalous persistence of primitive reflexes (PRs) and craniosacral blocks (CBs) are unknown, as well as their impact on neurodevelopment, behaviour disorders and related consequences. We aim to know the prevalence of anomalous PRs and CBs in apparently healthy children and its relationships with behavior and neurodevelopment anomalies. Methods: Participants (n=120) were evaluated through physical examination to detect PRs and CBs, an ad hoc parent survey to collect perinatal events, and children behavior assessment by teachers using Battelle score. Results: PRs were present in 89.5%. Moro (70.8%), cervical asymmetric (78.3%) and cervical symmetric PRs (67.5%) were the most frequent observed PRs. CBs were found in 83.2%, and the most frequent CBs were dura mater (77.5%) and sphenoid bone (70%) blocks. Moro, cervical asymmetric and cervical symmetric active primitive reflexes are significantly associated to cranial blocks of dura mater, parietal zones, and sphenoid bone sway. Gestational disorders or perinatal complications were associated to a higher frequency of PRs and CBs. The presence of PRs and CBs were associated with abnormal Battelle scores and neurobehavioral problems. Conclusion: Presence of PRs and CBs in children without diagnosed diseases are frequent and related with disturbances in childhood neurodevelopment.
Assessment and management of Heart Failure in Patients with Chronic Kidney Disease
Authors: Guaricci Andrea Igoren , Sturdà Francesca , Russo Roberto , Basile Paolo , Baggiano Andrea , Mushtaq Saima , Fusini Laura , Fazzari Fabio , Bertrandino Fulvio , Monitillo Francesco , Carella Maria Cristina , Simonini Marco , Pontone Gianluca , Ciccone Marco Matteo , Grandaliano Giuseppe , Vezzoli Giuseppe , Pesce Francesco
Published: April 2023

CKD in HF patients is very common condition, their dysfunction is closely linked and influence each other, so their management required multidisciplinary and personalized approaches. The diagnosis of HF and CDK relies on signs and symptoms. Several tools, such as blood-based biomarkers and echography help us to clarify and discriminate the main characteristics of these patients. Evidence in improving survival due to new drug-employment in HF, has increasingly challenged physicians to manage patients with multiple diseases, especially in patients with CKD. The difficulty is in the safe administration of these drugs in patients with HF and CKD. Knowing up to which values ​​of creatinine or renal clearance any drug can be administered is fundamental. We wanted to summarize, on this sizable and complex topic, the experiences of various prior study to get clearer ideas and a more precise reference about the assessment and management of HF and CKD.
Nyrdvomenshor Gem Stones Deposit, Polar Urals, Russia
Authors: Kislov Evgeniy V. , Popov Mikhail P. , Nurmukhametov Firat M. , Posokhov Viktor F. , Vanteev Vladislav V.
Published: April 2023

We have studied quality characteristics, chemical, mineral and isotope composition of nephrite, diopsidite and rodingite of the Nyrdvomenshor deposit in the Polar Urals. We applied the visual petrographic and mineralogical studies, X-ray spectral fluorescence, ICP-MS analysis, scanning electron microscope with the dispersive microanalysis system, oxygen isotope composition was measured. According to its quality characteristics, the nephrite is substandard. Here, uvarovite, which forms idiomorphic grains, sometimes sheath-like, less often xenomorphic elongated, and substituting chromite are commonly encountered. The nephrite was formed due to both metamorphic and metasomatic processes. Serpentinite was replaced by diopsidite, which was then replaced by nephrite. Metamorphism intensified metasomatism of the serpentinite melange and provided a cryptocrystalline tangled-fibrous structure of the nephrite. Then metamorphism and metasomatism led to the formation of omphacite and cracking of the nephrite, which reduced its quality. As these processes progressed, contribution of crustal fluid increased.
Eventual Increase of Solar Electricity Production and Desalinated Water through the Formation of a Channel between the Mediterranean and the Dead Sea
Authors: Lineykin Shimon , Sharma Abhishek , Averbukh Moshe
Published: April 2023

Currently, the Israeli energy industry faces the challenge of a considerable increase in solar electricity production. Being a relatively isolated system, the significant expansion of solar electricity may cause problems with electricity quality. The electrical storage installation can resolve this problem. In Israel's situation, the optimal solution can be the creation of a channel between the Mediterranean and the Dead Sea. The channel can solve three closely related problems: the increased production of desalinated water for domestic, industrial, and agricultural needs; the prevention of a permanent Dead Sea level decline and its imminent disappearance; the development of hydro-pumping electrical storage stations; and the creation of numerous PV facilities in the Negev area for national electricity generation. However, a detailed analysis should be done for the estimation of the possible increase of solar electric generation with the consideration of a stochastic PV outcome and a potential ability to use the Dead Sea for the brine discharge from electrical hydro-storage plants.
Space as Capital. or Why Geography Matters for Ageing
Authors: Decker Pascal De
Published: April 2023

Flanders (Belgium) is ageing at a rapid pace. Elderly people will continue to live at home in large numbers, partly because this is encouraged by the government. However, many homes are not adapted to reduced mobility. For example, it is not possible to circulate with a wheelchair. But also the living environment poses challenges for the elderly. Flanders is known for a far-reaching spread of housing and facilities, with the result that daily facilities can often only be reached by car. As a result of this spatial fragmentation, the elderly themselves often live for care providers in unreachable places. This ensures, among other things, that the in-home help travels several car kilometers. And research shows that so-called informal care is not self-evident either. Because what about the elderly who don't have children living nearby? Or with the residents who only see their next neighbor hundreds of meters away, who is also often a little mobile peer? The (untouched) appropriateness of the home, the presence or absence of facilities or neighbors, all of which belongs to what we can call the spatial capital of an environment. If this is not present, an autonomous life for a less mobile elderly person is not possible. The argument is that without sufficient spatial capital, the policy options are to allow the elderly to live in their homes for as long as possible or caring neighborhoods dead ends.
Optimal Nutritional Support Strategy based on the Association between Modified NUTRIC Score and 28-Day Mortality in Critically ill Patients: A Prospective Study
Authors: Park Sunny , Park So hyang , Kim Ye ju , Lee Geon Ho , Kim Hyung-Sook , Lim Sung Yoon , Choi Soo An
Published: April 2023

Background: Malnutrition in critically ill paitents is closely linked with clinical outcomes. During acute inflammatory states, nutrition cannot reverse the loss of body cell mass completely. Studies on nutritional screening and strategy considering metabolic changes not yet been conducted. We aimed to identify nutrition strategies using the modified Nutrition Risk in the Critically ill (mNUTIRC) score. Methods: Nutrition support data, laboratory nutrition indicators, and prognosis indices were prospectively collected on the 2nd and 7th day after admission. It is to identify the effect of changes on the metabolic status and critical target of nutrition intervention. To discriminate the high-risk group of malnutrition, receiver operating characteristic curves were plotted. Risk factors associated with 28 day-mortality were evaluated using multivariable Cox proportional hazards regression. Results: A total of 490 and 266 patients were analyzed on the 2nd and 7th day, respectively. Only the mNUTRIC score showed significant differences in nutritional risk stratification. The use of vasopressors, hypo-protein supply (< 1.0 g/kg/day), high mNUTRIC score and hypoalbuminemia (<2.5 mg/dl) in the recovery phase was strongly associated with 28-day mortality. Conclusions: The implementation of the mNUTRIC score and protein supply in the post-acute phase is critical to improve 28-day mortality in critically ill patients.
Cultured Meat Safety Research Priorities: Regulatory and Governmental Perspectives
Authors: Ong Kimberly J. , Tejeda-Saldana Yadira , Duffy Breanna , Holmes Dwayne , Kukk Kora , Shatkin Jo Anne
Published: April 2023

As with every new technology, safety demonstration is a critical component of bringing products to market and gaining public acceptance for cultured meat and seafood. This manuscript develops research priorities from the findings from a series of interviews and workshops with governmental scientists and regulators from food safety agencies in fifteen jurisdictions globally.  The interviews and workshops aimed to identify the key safety questions and priority areas of research. Participants raised questions about which aspects of cultured meat and seafood production are novel, and the implications of the paucity of public information on the topic. Novel parameters and targets may require the development of new analytical methods or adaptation and validation of existing ones, including for a diversity of product types and processes. Participants emphasized that data sharing of these efforts would be valuable, similar to those already developed and used in the food and pharmaceutical fields. Contributions to such databases from the private and public sectors would speed general understanding as well as efforts to make evaluations more efficient. In turn, these resources, combined with transparent risk assessment, will be critical elements of building consumer trust in cultured meat and seafood products.
Transplanting Heterologous Mitochondria from Human Umbilical Vein Endothelial Cells Reduces the Malignancy of Melanoma Cells
Authors: Kuo Fu-Chen , Cheng Bi-Ling , Tsai Ching-Chung , Chen Ping-Chen , Tsai Hsin-Yi , Tsai Kuen-Jang , Huang Yaw-Bin , Liu Chung-Jung , Wu Deng-Chyang , Lin Ming-Wei , Huang Bin
Published: April 2023

The development of using mitochondrial transplantation in medical therapy are currently discussed. According to the endosymbiotic theory, the movement of mitochondria between different cells is possible. Therefore, an idea of transferring the mitochondria purified from the cells with a limited lifespan to shorten the lifespan of immortal cancer cells was generated. Human umbilical vein endothelial cell (HUVEC) is a kind of primary cell with a limited lifespan. In the present study, the mitochondria purified from HUVEC were applied to alter the malignance of B16F10 melanoma cell. In the comparison of the basic function of mitochondria, HUVEC mitochondria exhibited a higher mitochondrial membrane potential (MMP), while the lower levels in ATP, mitochondrial DNA (mt-DNA) and mitochondrial protein (mt-protein) as compared to melanoma B16F10. After transplanted the B16F10 with HUVEC mitochondria, the migration, invasion, and the proteins involved in cancer stemness were decreased, however, the proteins involved in cell proliferation, such as cyclin D1 and cyclin E1 were increased. In addition, the levels of ATP, mt-DNA and mt-protein of B16F10 were also reduced. As for the dynamics of mitochondria, the reduced expressions of DRP1 and LC3 II revealed that transferred mitochondria can attenuate the mitophagy of B16F10. In mice, inoculated the B16F10 carrying the transplanted HUVEC mitochondria resulted in the larger size of tumor, which is corresponded to the higher levels of cyclin D1 and E1. Interestingly, the lower expressions of N-cadherin, α-SMA and MMP-9 reveled the tumor were decreased in mesenchymal characteristics. Therefore, despite the HUVEC mitochondria did not inhibit the proliferation of B16F10, the metastatic characteristic was reduced.
Mutant IDH in Gliomas: Role in Cancer and Treatment Options
Authors: Solomou Georgios , Finch Alina , Asghar Asim , Bardella Chiara
Published: April 2023

Altered metabolism is a common feature of many cancers and in some cases is a consequence of mutation in metabolic genes, such as the ones involved in Krebs cycle. Isocitrate dehydrogenase (IDH) gene is mutated in many gliomas and other cancers. Physiologically IDH converts isocitrate to αketoglutarate (αKG), but when mutated, IDH reduces αKG to D2-hydroxyglutarate (D2-HG). D2-HG accumulates at high levels in IDH mutant cancers, and in the last decade, a massive effort has been done to develop small inhibitors targeting mutant IDH. In this review, we summarize current knowledge about the cellular and molecular consequences of IDH mutations, and the therapeutic approached developed to target IDH mutant tumours, with a focus on gliomas.
Racial/Ethnic Disparities in Prostate Cancer 5-Year Survival: The Role of Health-Care Access and Disease Severity
Authors: El Khoury Christiane J. , Clouston Sean A. P.
Published: April 2023

Introduction Prostate Cancer (PCa) exhibits one of the widest racial and socioeconomic disparities. PCa disparities have also been widely linked to location as living in more deprived regions was associated with lower healthcare access and worse outcomes. This study aims to examine PCa survival across various US counties in function of different socioeconomic profiles and discuss the role of potential intermediary factors.

Methods The SEER database linked to county-level SES was utilized. Five-year PCa-specific survival using the Kaplan Meier method was performed for 5 racial/ethnic categories in function of SES quintiles. Multilevel Cox proportional hazards regression was performed to assess the relationship between county-level SES and PCa survival. Multivariate regression analysis was performed to examine the role of healthcare utilization and severity.

Results 279,000 PCa records were extracted, 5-year PCa-specific survival was 94%. Overall, living in counties with worst poverty/income quintile and highest proportions of foreign-born/language-isolated increased PCa mortality by 23% each. No association was observed with county-level High-School education, while Bachelor’s-level education decreased mortality risk by 23%. Associations varied considerably upon racial/ethnic stratification. Multilevel analyses showed varying contributions of individual and area-level factors to survival within minorities. The relationship between SES and PCa survival appeared to be influenced by healthcare utilization and disease stage/grade.

Discussion Racial/ethnic categories responded differently under similar county-level SES and individual-level factors to the point where disparities reversed in Hispanics. The inclusion of Healthcare utilization and severity factors may provide partial early support for their role as intermediaries. Healthcare access (insurance) might not necessarily be associated with better PCa survival, through performing biopsy and or/surgery. County-level education plays an important role in PCa decision-making as it might elucidate discussions of other non-invasive management options.

Conclusion Findings of this study demonstrate that interventions need to be tailored according to each group's needs. This potentially informs the focus of public health efforts in terms of planning and prioritizing. This study could also direct further research delving into pathways between area-level characteristics with PCa survival.
Towards an Artificial Intelligence Based Chronic Disease Management
Authors: Cruz Castañeda William Alberto , Bertemes Filho Pedro
Published: April 2023

Chronic non-communicable diseases (NCDs) are major public health problems and a significant financial burden on public health systems. By 2030, mortality due to NCDs, such as cardiovascular diseases, cancer, respiratory diseases, and diabetes, is predicted to increase in Brazil. A peculiar aspect of NCDs involves their long-term and integrated care management. This paper proposes a chronic disease management platform based on artificial intelligence to deliver digital health services everywhere. The proposed platform is anchored and built with healthcare 4.0 technologies, such as wearable devices, the internet of medical things, and artificial intelligence cloud-based solutions that allow the deployment of a smart healthcare system. In addition, the paper presents the feasibility of the platform in a diabetes prediction study case. For the study case, an initial dataset was established with bio-impedance, oxygen concentration, pulse rate, skin impedance, and skin temperature attributes. A baseline was implemented with ten regression models to assess the prediction performance of the mean squared error, root mean squared error, and r-squared score to compare predictive findings with capillary blood glucose measurements. Results evidence that the decision tree regressor and three ensemble methods (bagging decision tree regressor, random forest regressor, and AdaBoost regressor) yielded improvement over the other models. Moreover, a comparison among those models revealed that the decision tree regressor outperforms them and presents promissory outcomes.
Targeting Nociceptors and Transient Receptor Potential Channels for the Treatment of Migraine
Authors: Cohen Cinder Faith , Roh Jueun , Lee Sang Hoon , Park Chul-Kyu , Berta Temugin
Published: April 2023

Migraine is a neurovascular disorder that affects approximately 12% of the global population. While its exact causes are still being studied, researchers believe that nociceptors in the trigeminal ganglia play a key role in the pain signals of migraine. These nociceptors innervate the intracranial meninges and convey pain signals from the meninges to the thalamus. Targeting these nociceptors is considered promising due to their accessibility and distinct molecular profile, which includes the expression of several transient receptor potential (TRP) channels. These channels have been linked to various pain conditions, including migraine. This review discusses the role and mechanisms of nociceptors in migraine, the challenges of current antimigraine drugs, and the evidence for well-studied and emerging TRP channels, particularly TRPC4, as novel targets for migraine prevention and treatment.
Scalar Product for a Version of Minisuperspace Model with the Grassmann Variables
Authors: Cherkas Sergey L. , Kalashnikov Vladimir L.
Published: April 2023

The Grassmann variables are used to transform a system with constraints into an unconstraint system. As a result, the Schrödinger equation arises instead of the Wheeler-DeWitt one. Formally, the Schrödinger equation describes a system’s evolution, but a definition of the scalar product is needed to calculate the mean values of the operators. We suggest an explicit formula for the scalar product. The calculation of the mean values is compared with the etalon method, in which a redundant degree of freedom is excluded. Nevertheless, we could note that a complete correspondence with the etalon picture is not found. Apparently, the picture with Grassmann variables requires further search for underlying Hilbert space.
PTEN Overexpression Alters Autophagy Levels and Slows Sodium Arsenite-Induced Hepatic Stellate Cell Fibrosis
Authors: Huang Fei , Ding Guanxin , Yuan Yanjie , Zhao Lijun , Ding Wenmeng , Wu Shunhua
Published: April 2023

Background: Exposure to inorganic arsenic (iAs) remains a global public health problem. The liver is the main target organ of arsenic, leading to arsenic-induced liver fibrosis. Autophagy is involved. Phosphatase and tensin homology deleted on chromosome ten (PTEN) may participate in arsenic-induced liver fibrosis by regulating autophagy, but the exact mechanisms remain unclear. We established a mouse model of arsenic poisoning through the drinking water, and a fibrosis model using the huma stellate cell (HSC) line LX-2, which was exposed to NaAsO2 for 24h. HE and Masson staining was adopted to observe the degree of liver fibrosis. The cells were transfected using PTEN overexpression plasmid. Western blot and qRT-PCR were used to determine the levels of protein/mRNA expression. The in vivo results were confirmed in HSCs exposed to NaAsO2, with changes suggesting fibrosis as seen in mice. NaAsO2 upregulated the expression of the autophagic markers microtubule-associated protein light chain A/B (LC3), recombinant human autophagy effector protein (Beclin-1), hairy and enhancer of split homolog-1 (HES1), but downregulated PTEN. α-smooth muscle actin (α-SMA) expression was significantly upregulated in all NaAsO2 groups. PTEN overexpression altered NaAsO2-induced autophagy which LC3, Beclin-1 were downregulated. Notch1, HES1, α-SMA, and collagenⅠexpression were all downregulated in the NaAsO2 groups. In conclusion, PTEN overexpression might decrease autophagy and inhibit fibrosis progression caused by this toxin. The NOTCH1/HES1 pathway is likely to be involved in this process. Most previous studies did not investigate PTEN and arsenic-induced liver fibrosis specifically. The present study highlights the importance of targeting PTEN for the management of arsenic exposure.