bluuebunny/crossref_metadata_2025 huggingface dataset:
Efficient Oxidative Resolution of 1-Phenylphosphol-2-Ene and Diels–Alder Synthesis of Enantiopure Bicyclic and Tricyclic P-Stereogenic C-P Heterocycles
Authors: Pietrusiewicz K. Michał , Koprowski Marek , Drzazga Zbigniew , Parcheta Renata , Łastawiecka Elżbieta , Demchuk Oleg M. , Justyniak Iwona
Published: March 2020

1-Phenylphosphol-2-ene 1-oxide is effectively resolved by L-menthyl bromoacetate to afford both SP and RP enantiomers of 1-phenylphosphol-2-ene 1-oxide on a multigram scale. The resolved 1-phenylphosphol-2-ene oxide has been found to undergo face-selective and endo-selective cycloadditions with a series of acyclic and cyclic dienes to produce enantiopure P-stereogenic C-P heterocycles of hexahydrophosphindole and hexahydrobenzophosphindole as well as phospha[5.2.1.02,6]decene and phospha[5.2.2.02,6]undecene structures. Conversions of these cycloadducts to the fully saturated heterocyclic systems as well as to their P (III), P = S, P = Se and P-BH3 derivatives have been demonstrated to occur with retention of configuration and preservation of configurational homogeneity at P. A perplexing case of stereomutation at P during reduction of a tricyclic β-hydroxy phosphine oxide by PhSiH3 at 80 °C has been recorded.
Natural Language Processing Model for Automatic Analysis of Cybersecurity-Related Documents
Authors: Georgescu Tiberiu-Marian
Published: March 2020

This paper describes the development and implementation of a natural language processing model based on machine learning which performs cognitive analysis for cybersecurity-related documents. A domain ontology was developed using a two-step approach: (1) the symmetry stage and (2) the machine adjustment. The first stage is based on the symmetry between the way humans represent a domain and the way machine learning solutions do. Therefore, the cybersecurity field was initially modeled based on the expertise of cybersecurity professionals. A dictionary of relevant entities was created; the entities were classified into 29 categories and later implemented as classes in a natural language processing model based on machine learning. After running successive performance tests, the ontology was remodeled from 29 to 18 classes. Using the ontology, a natural language processing model based on a supervised learning model was defined. We trained the model using sets of approximately 300,000 words. Remarkably, our model obtained an F1 score of 0.81 for named entity recognition and 0.58 for relation extraction, showing superior results compared to other similar models identified in the literature. Furthermore, in order to be easily used and tested, a web application that integrates our model as the core component was developed.
Image Encryption Algorithm Based on Tent Delay-Sine Cascade with Logistic Map
Authors: Zhang Guidong , Ding Weikang , Li Lian
Published: March 2020

We propose a new chaotic map combined with delay and cascade, called tent delay-sine cascade with logistic map (TDSCL). Compared with the original one-dimensional simple map, the proposed map has increased initial value sensitivity and internal randomness and a larger chaotic parameter interval. The chaotic sequence generated by TDSCL has pseudo-randomness and is suitable for image encryption. Based on this chaotic map, we propose an image encryption algorithm with a symmetric structure, which can achieve confusion and diffusion at the same time. Simulation results show that after encryption using the proposed algorithm, the entropy of the cipher is extremely close to the ideal value of eight, and the correlation coefficients between the pixels are lower than 0.01, thus the algorithm can resist statistical attacks. Moreover, the number of pixel change rate (NPCR) and the unified average changing intensity (UACI) of the proposed algorithm are very close to the ideal value, which indicates that it can efficiently resist chosen-plain text attack.
Fractional Dynamics in Soccer Leagues
Authors: Lopes António M. , Tenreiro Machado Jose A.
Published: March 2020

This paper addresses the dynamics of four European soccer teams over the season 2018–2019. The modeling perspective adopts the concepts of fractional calculus and power law. The proposed model embeds implicitly details such as the behavior of players and coaches, strategical and tactical maneuvers during the matches, errors of referees and a multitude of other effects. The scale of observation focuses the teams’ behavior at each round. Two approaches are considered, namely the evaluation of the team progress along the league by a variety of heuristic models fitting real-world data, and the analysis of statistical information by means of entropy. The best models are also adopted for predicting the future results and their performance compared with the real outcome. The computational and mathematical modeling lead to results that are analyzed and interpreted in the light of fractional dynamics. The emergence of patterns both with the heuristic modeling and the entropy analysis highlight similarities in different national leagues and point towards some underlying complex dynamics.
Multi-Granulation Picture Hesitant Fuzzy Rough Sets
Authors: Mathew Bibin , John Sunil Jacob , Alcantud José Carlos R.
Published: March 2020

We lay the theoretical foundations of a novel model, termed picture hesitant fuzzy rough sets, based on picture hesitant fuzzy relations. We also combine this notion with the ideas of multi-granulation rough sets. As a consequence, a new multi-granulation rough set model on two universes, termed a multi-granulation picture hesitant fuzzy rough set, is developed. When the universes coincide or play a symmetric role, the concept assumes the standard format. In this context, we put forward two new classes of multi-granulation picture hesitant fuzzy rough sets, namely, the optimistic and pessimistic multi-granulation picture hesitant fuzzy rough sets. Further, we also investigate the relationships among these two concepts and picture hesitant fuzzy rough sets.
On Spectral Properties of Doubly Stochastic Matrices
Authors: Rehman Mutti-Ur , Alzabut Jehad , Brohi Javed Hussain , Hyder Arfan
Published: March 2020

The relationship among eigenvalues, singular values, and quadratic forms associated with linear transforms of doubly stochastic matrices has remained an important topic since 1949. The main objective of this article is to present some useful theorems, concerning the spectral properties of doubly stochastic matrices. The computation of the bounds of structured singular values for a family of doubly stochastic matrices is presented by using low-rank ordinary differential equations-based techniques. The numerical computations illustrating the behavior of the method and the spectrum of doubly stochastic matrices is then numerically analyzed.
New Insights into the Toxicokinetics of 3,4-Dichloroaniline in Early Life Stages of Zebrafish (Danio rerio)
Authors: Schiwy Sabrina , Herber Ann-Kathrin , Hollert Henner , Brinkmann Markus
Published: March 2020

In the fish embryo toxicity (FET) test with zebrafish (Danio rerio) embryos, 3,4-dichloroaniline (3,4-DCA) is often employed as a positive control substance. Previous studies have characterized bioconcentration and transformation of 3,4-DCA in this test under flow-through conditions. However, the dynamic changes of chemical concentrations in exposure media and embryos were not studied systematically under the commonly used semi-static exposure conditions in multiwell plates. To overcome these limitations, we conducted semi-static exposures experiments where embryolarval zebrafish were exposed to 0.5, 2.0, and 4.0 mg L−1 of 3,4-DCA for up to 120 hpf, with 24-h renewal intervals. During each renewal interval, concentrations of 3,4-DCA were quantified in water samples at 0, 6, 18, and 24 h using high-performance liquid chromatography with diode array detection. Levels of 3,4-DCA in larvae were measured after 120 h exposure. Concentrations of 3,4-DCA in the test vessels decreased rapidly during exposure. Taking these dynamics into account, bioconcentration factors in the present study ranged from 12.9 to 29.8 L kg−1, depending on exposure concentration. In summary, this study contributed to our knowledge of chemical dynamics in the FET test with embryolarval zebrafish, which will aid in defining suitable exposure conditions for future studies.
Concentration- and Time-Dependent Effects of Benzalkonium Chloride in Human Lung Epithelial Cells: Necrosis, Apoptosis, or Epithelial Mesenchymal Transition
Authors: Kim Sou Hyun , Kwon Doyoung , Lee Seunghyun , Son Seung Won , Kwon Jung-Taek , Kim Pil-Je , Lee Yun-Hee , Jung Young-Suk
Published: March 2020

Benzalkonium chloride (BAC), an antimicrobial agent in inhalable medications and household sprays, has been reported to be toxic to pulmonary organs. Although cell membrane damage has been considered as the main cytotoxic mechanism of BAC, its concentration- and time-dependent cellular effects on lung epithelium have not been fully understood. In the present study, human lung epithelial (H358) cells were exposed to 0.2–40 μg/mL of BAC for 30 min or 21 days. Cell membranes were rapidly disrupted by 30 min exposure, but 24 h incubation of BAC (4–40 μg/mL) predominantly caused apoptosis rather than necrosis. BAC (2–4 μg/mL) induced mitochondrial depolarization, which may be associated with increased expression of pro-apoptotic proteins (caspase-3, PARP, Bax, p53, and p21), and decreased levels of the anti-apoptotic protein Bcl-2. The protein expression levels of IRE1α, BiP, CHOP, and p-JNK were also elevated by BAC (2–4 μg/mL) suggesting the possible involvement of endoplasmic reticulum stress in inducing apoptosis. Long-term (7–21 days) incubation with BAC (0.2–0.6 μg/mL) did not affect cell viability but led to epithelial-mesenchymal transition (EMT) as shown by the decrease of E-cadherin and the increase of N-cadherin, fibronectin, and vimentin, caused by the upregulation of EMT transcription factors, such as Snail, Slug, Twist1, Zeb1, and Zeb2. Therefore, we conclude that apoptosis could be an important mechanism of acute BAC cytotoxicity in lung epithelial cells, and chronic exposure to BAC even at sub-lethal doses can promote pulmonary EMT.
A Comparison of the Nephrotoxicity of Low Doses of Cadmium and Lead
Authors: Satarug Soisungwan , Gobe Glenda C. , Ujjin Pailin , Vesey David A.
Published: March 2020

Environmental exposure to moderate-to-high levels of cadmium (Cd) and lead (Pb) is associated with nephrotoxicity. In comparison, the health impacts of chronic low-level exposure to Cd and Pb remain controversial. The aim of this study was to therefore evaluate kidney dysfunction associated with chronic low-level exposure to Cd and Pb in a population of residents in Bangkok, Thailand. The mean age and the estimated glomerular filtration rate (eGFR) for 392 participants (195 men and 197 women) were 34.9 years and 104 mL/min/1.73 m2, respectively, while the geometric mean concentrations of urinary Cd and Pb were 0.25 μg/L (0.45 μg/g of creatinine) and 0.89 μg/L (1.52 μg/g of creatinine), respectively. In a multivariable regression analysis, the eGFR varied inversely with blood urea nitrogen in both men (β = −0.125, p = 0.044) and women (β = −0.170, p = 0.008), while inverse associations of the eGFR with urinary Cd (β = −0.132, p = 0.043) and urinary Pb (β = −0.130, p = 0.044) were seen only in women. An increased urinary level of Cd to the median level of 0.38 μg/L (0.44 μg/g of creatinine) was associated with a decrease in the eGFR by 4.94 mL/min/1.73 m2 (p = 0.011). The prevalence odds of a reduced eGFR rose 2.5-, 2.9- and 2.3-fold in the urinary Cd quartile 3 (p = 0.013), the urinary Cd quartile 4 (p = 0.008), and the urinary Pb quartile 4 (p = 0.039), respectively. This study suggests that chronic exposure to low-level Cd is associated with a decline in kidney function and that women may be more susceptible than men to nephrotoxicity due to an elevated intake of Cd and Pb.
Chronodisruption: A Poorly Recognized Feature of CKD
Authors: Carriazo Sol , Ramos Adrián M , Sanz Ana B , Sanchez-Niño Maria Dolores , Kanbay Mehmet , Ortiz Alberto
Published: March 2020

Multiple physiological variables change over time in a predictable and repetitive manner, guided by molecular clocks that respond to external and internal clues and are coordinated by a central clock. The kidney is the site of one of the most active peripheral clocks. Biological rhythms, of which the best known are circadian rhythms, are required for normal physiology of the kidneys and other organs. Chronodisruption refers to the chronic disruption of circadian rhythms leading to disease. While there is evidence that circadian rhythms may be altered in kidney disease and that altered circadian rhythms may accelerate chronic kidney disease (CKD) progression, there is no comprehensive review on chronodisruption and chronodisruptors in CKD and its manifestations. Indeed, the term chronodisruption has been rarely applied to CKD despite chronodisruptors being potential therapeutic targets in CKD patients. We now discuss evidence for chronodisruption in CKD and the impact of chronodisruption on CKD manifestations, identify potential chronodisruptors, some of them uremic toxins, and their therapeutic implications, and discuss current unanswered questions on this topic.
Bovine Herpesvirus-4-Vectored Delivery of Nipah Virus Glycoproteins Enhances T Cell Immunogenicity in Pigs
Authors: Pedrera Miriam , Macchi Francesca , McLean Rebecca K. , Franceschi Valentina , Thakur Nazia , Russo Luca , Medfai Lobna , Todd Shawn , Tchilian Elma Z. , Audonnet Jean-Christophe , Chappell Keith , Isaacs Ariel , Watterson Daniel , Young Paul R. , Marsh Glenn A. , Bailey Dalan , Graham Simon P. , Donofrio Gaetano
Published: March 2020

Nipah virus (NiV) is an emergent pathogen capable of causing acute respiratory illness and fatal encephalitis in pigs and humans. A high fatality rate and broad host tropism makes NiV a serious public and animal health concern. There is therefore an urgent need for a NiV vaccines to protect animals and humans. In this study we investigated the immunogenicity of bovine herpesvirus (BoHV-4) vectors expressing either NiV attachment (G) or fusion (F) glycoproteins, BoHV-4-A-CMV-NiV-GΔTK or BoHV-4-A-CMV-NiV-FΔTK, respectively in pigs. The vaccines were benchmarked against a canarypox (ALVAC) vector expressing NiV G, previously demonstrated to induce protective immunity in pigs. Both BoHV-4 vectors induced robust antigen-specific antibody responses. BoHV-4-A-CMV-NiV-GΔTK stimulated NiV-neutralizing antibody titers comparable to ALVAC NiV G and greater than those induced by BoHV-4-A-CMV-NiV-FΔTK. In contrast, only BoHV-4-A-CMV-NiV-FΔTK immunized pigs had antibodies capable of significantly neutralizing NiV G and F-mediated cell fusion. All three vectored vaccines evoked antigen-specific CD4 and CD8 T cell responses, which were particularly strong in BoHV-4-A-CMV-NiV-GΔTK immunized pigs and to a lesser extent BoHV-4-A-CMV-NiV-FΔTK. These findings emphasize the potential of BoHV-4 vectors for inducing antibody and cell-mediated immunity in pigs and provide a solid basis for the further evaluation of these vectored NiV vaccine candidates.
Experimental Study of Local Scour around Caissons under Unidirectional and Tidal Currents
Authors: Xiang Qiqi , Wei Kai , Qiu Fang , Yao Changrong , Li Yadong
Published: March 2020

Local scour around caissons under currents has become one of the main factors affecting the safety of foundation construction and operation in coastal and offshore bridge engineering. Local scour occurs not only in the operation stage, when the caisson has settled into the sediment, but also in the construction stage, when the caisson is suspended in water. In this study, the local scour induced by unidirectional and tidal currents around settled caissons with different cross-sections (circular, square, and diamond) was experimentally investigated. Circular and square caissons were selected to investigate the difference in local scour of suspended caissons under unidirectional and tidal currents. The main findings from the experimental results were: (1) the temporal development of scour under tidal current was slower than that of unidirectional current; (2) the effect of current type can significantly influence the size and location of maximum scour depth around circular and square caissons; (3) the appropriate choice of cross-section could reduce the maximum scour depth around the settled caisson; (4) the maximum scour depth of tidal current was smaller than that of unidirectional current when the caisson was settled into the sediment, while the opposite effect occurred when the caisson was suspended in water.
Characterization of Hyporheic Exchange Drivers and Patterns within a Low-Gradient, First-Order, River Confluence during Low and High Flow
Authors: Martone Ivo , Gualtieri Carlo , Endreny Theodore
Published: March 2020

Confluences are nodes in riverine networks characterized by complex three-dimensional changes in flow hydrodynamics and riverbed morphology, and are valued for important ecological functions. This physical complexity is often investigated within the water column or riverbed, while few studies have focused on hyporheic fluxes, which is the mixing of surface water and groundwater across the riverbed. This study aims to understand how hyporheic flux across the riverbed is organized by confluence physical drivers. Field investigations were carried out at a low gradient, headwater confluence between Baltimore Brook and Cold Brook in Marcellus, New York, USA. The study measured channel bathymetry, hydraulic permeability, and vertical temperature profiles, as indicators of the hyporheic exchange due to temperature gradients. Confluence geometry, hydrodynamics, and morphodynamics were found to significantly affect hyporheic exchange rate and patterns. Local scale bed morphology, such as the confluence scour hole and minor topographic irregularities, influenced the distribution of bed pressure head and the related patterns of downwelling/upwelling. Furthermore, classical back-to-back bend planform and the related secondary circulation probably affected hyporheic exchange patterns around the confluence shear layer. Finally, even variations in the hydrological conditions played a role on hyporheic fluxes modifying confluence planform, and, in turn, flow circulation patterns.
Ancient Coastal Changes Due to Ground Movements and Human Interventions in the Roman Portus Julius (Pozzuoli Gulf, Italy): Results from Photogrammetric and Direct Surveys
Authors: Aucelli Pietro P. C. , Mattei Gaia , Caporizzo Claudia , Cinque Aldo , Troisi Salvatore , Peluso Francesco , Stefanile Michele , Pappone Gerardo
Published: March 2020

This research aims to evaluate the amount of vertical ground movements during Roman times inside the archaeological area of Portus Julius (Gulf of Pozzuoli) using high-precision surveys on the most reliable archaeological sea-level markers. Measuring the submersion of ancient floors, structural elements belonging to a former fish tank, and several roman pilae, two different relative sea levels (RSLs), related to the beginning and the end of the first century BCE, respectively, −4.7/−5.20 m and −3.10 m MSL (mean sea level), were detected. A photogrammetric survey was carried out in order to produce a 3D model of the fish tank. The results in terms of the RSL variations have enabled us to reconstruct a morpho-evolution of the ancient coastal sector during the last 2.1 kyBP. At the beginning of the first century BCE, the area was characterized by a sheltered gulf with numerous maritime villae located along the coast. In 37 BCE, the construction of the military harbour of Portus Julius strongly modified the paleogeography of the sector, which was also affected by a prevailing subsidence at least until the end of the first century BCE (year 12 BCE), when the port was converted into a commercial hub.
Lessons Learnt from the Long-Term Management of a Large (Re)constructed Wetland, the Kis-Balaton Protection System (Hungary)
Authors: Honti Mark , Gao Chunni , Istvánovics Vera , Clement Adrienne
Published: March 2020

Environmental management decisions should be made based on solid scientific evidence that relies on monitoring and modeling. In practice, changing economic, societal, and political boundary conditions often interfere with management during large, long, and complex projects. The result may be a sub-optimal development path that may finally diverge from the original intentions and be economically or technically ineffective. Nevertheless, unforeseen benefits may be created in the end. The Kis-Balaton wetland system is a typical illustration of such a case. Despite tremendous investments and huge efforts put in monitoring and modeling, the sequence of decisions during implementation can hardly be considered optimal. We use a catchment model and a basic water quality model to coherently review the impacts of management decisions during the 30-year history. Due to the complexity of the system, science mostly excelled in finding explanations for observed changes after the event instead of predicting the impacts of management measures a priori. In parallel, the political setting and sectoral authorities experienced rearrangements during system implementation. Despite being expensive as a water quality management investment originally targeting nutrient removal, the Kis-Balaton wetland system created a huge ecological asset, and thereby became worth the price.
Direct Numerical Simulations on Jets during the Propagation and Break down of Internal Solitary Waves on a Slope
Authors: Xu Jin , Avital Eldad J. , Wang Lingling
Published: March 2020

Jet flows often have an important role in the water environment. The aim of this research is to study the dilution of jets due to complex velocity fields induced by internal solitary waves in stratified water. Direct numerical simulations are used to study vertical jet flows during the propagation and breaking of internal solitary waves (ISWs) with elevation type on a slope. Energy analysis shows that the internal interface is able to absorb kinetic energy from the jet and that for Re < 10,000 with Ri > 3.7, the ISWs can stay stable during the propagation within the presence of jet flows. The vortices jointly induced by the jets and the ISWs are observed at the bottom behind the ISW’s crest. The transport of the jet’s emitted scalar by the ISWs can be divided into two parts; some is transported by the moving interface and the rest by the bottom vortices. The ultimate transport length scales of two types are defined, and it is found that when the center of the jet inlet approaches the slope, the extension of the bottom vortices into the slope will lead to strong mixing. That causes increasing scalar concentration over the slope of the scalar that originated from the jet.
Drought and Ecological Flows in the Lower Guadiana River Basin (Southwest Iberian Peninsula)
Authors: Pulido-Calvo Inmaculada , Gutiérrez-Estrada Juan Carlos , Sanz-Fernández Víctor
Published: March 2020

Drought temporal characterization is a fundamental instrument in water resource management and planning of basins with dry-summer Mediterranean climate and with a significant seasonal and interannual variability of precipitation regime. This is the case for the Lower Guadiana Basin, where the river is the border between Spain and Portugal (Algarve-Baixo Alentejo-Andalucía Euroregion). For this transboundary basin, a description and evaluation of hydrological drought events was made using the Standardized Precipitation Index (SPI) with monthly precipitation time series of Spanish and Portuguese climatic stations in the study area. The results showed the occurrence of global cycles of about 25–30 years with predominance of moderate and severe drought events. It was observed that the current requirements of ecological flows in strategic water bodies were not satisfied in some months of October to April of years characterized by severe drought events occurring in the period from 1946 to 2015. Therefore, the characterization of the ecological status of the temporary streams that were predominant in this basin should be a priority in the next hydrologic plans in order to identify the relationships between actual flow regimes and habitat attributes, thereby improving environmental flows assessments, which will enable integrated water resource management.
Open-Access-Publikationsworkflow Für akademische Bücher
Authors: Böhm David , Grossmann Alexander , Reiche Michael , Schrader Antonia
Published: March 2020

Die zeitnahe, transparente und nachhaltige Verbreitung nachprüfbarer wissenschaftlicher
Ergebnisse ist eine der wesentlichen Anforderungen an die wissenschaftliche Kommunikation und
Infrastruktur. Open Access, also die offene und kostenfreie Nutzung von wissenschaftlicher
Literatur, ist hierfür die Grundvoraussetzung. Hochschulen und Universitäten sind in der Regel
die Institutionen, an denen Wissenschaftler neue Forschungsergebnisse erzeugen und zur
Veröffentlichung als Buch vorbereiten. Neben klassischen Wissenschaftsverlagen
veröffentlichen daher immer mehr Hochschulverlage wissenschaftliche Publikationen. Das
vorliegende Handbuch beschreibt einen nachhaltigen, allgemeingültigen State-of-the-Art-Workflow
zur Herstellung und Distribution von akademischen Büchern, der es Hochschulen und Universitäten
ermöglicht, bei weitest möglicher Verbreitung, Sichtbarkeit und Zugänglichkeit eigene
Forschungsarbeiten und Graduierungsschriften in digitaler Form im Open Access und als gedrucktes
Buch zu veröffentlichen. Dieses Workflow-Modell wird anhand ausgewählter Fallbeispiele als Proof
of Concept demonstriert und spiegelt den aktuellen Stand der derzeit im Verlagsbereich
technischen und wirtschaftlichen Möglichkeiten wider. Anhand der Fallbeispiele wurden zudem der
Zeit-, Kosten- und Personalaufwand erfasst, sodass anderen Hochschulen und Universitäten
Anhaltspunkte für nötige Investitionen bei der Gründung und dem Betrieb eigener OA-Hochschulverlage
gegeben werden.
IMAGEM, ARTE E PATHOSFORMEL EM ABY WARBURG
Authors: Barreto Priscila Risi Pereira
Published: March 2020

Este artigo versa sobre as ideias de imagem, arte e Pathosformeln nos estudos de Aby Warburg, na observância de que esses conceitos se misturam em grande parte de sua obra, cuja amplitude se estende em sua produção escrita, sua biblioteca e seu Atlas de imagens. Consideramos essa mistura fundamental em sua abordagem de pesquisa histórico-artística interdisciplinar, investigando diferentes suportes visuais como testemunhos do homem no tempo. Warburg defendeu a ampliação temática, espacial e metodológica da “nossa ciência da arte” e retomou a tradição de Jacob Burckhardt de comunhão entre História da Arte e História da Cultura. No rastro de detalhes que desvelavam coexistências, contradições e “significados invertidos” das tradições recorrentes e reativas em um mesmo espaço-tempo, rompeu as barreiras entre Ocidente e Oriente e reinterpretou as noções de clássico, antigo e do próprio Renascimento. Em uma chave interdisciplinar de pesquisa que considera a arte em seu contexto, foi além com sua proposta de uma ciência cultural e a “tarefa de considerar a obra de arte não apenas como espelho da vida histórica, mas também como instrumento de orientação no cosmos celeste”. (WARBURG, Aby. O legado do antigo. Escritos inéditos. Campinas, SP: Ed. UNICAMP, 2018a. v. 1, p. 32.)
Anais do VI Curso do Hotline de Hipertermia Maligna 2013
Authors: Silva Helga Cristina Almeida da
Published: March 2020

O atendimento à Hipertermia Maligna (HM) na Escola Paulista de Medicina – Universidade Federal de São Paulo (EPM/UNIFESP) é feito de forma multidisciplinar, acolhendo o paciente desde o momento da crise de HM, quando o anestesiologista entra em contato com o atendimento telefônico 24 horas, até a investigação da suscetibilidade por meio do teste de contratura muscular in vitro, estudo anatomopatológico do músculo e genética. Isso se deve à disponibilidade de estrutura na disciplina de Anestesiologia, Dor e Terapia  Intensiva, onde funcionam o HOTLINE (serviço brasileiro de orientação para o tratamento das crises suspeitas de HM, via contato telefônico em regime de plantão 24 horas por dia) e o CEDHIMA (Centro deEstudo, Diagnóstico e Investigação de Hipertermia Maligna, que realiza o Teste de Contratura Muscular in vitro). O CEDHIMA é referência da Secretaria de Saúde do Estado de São Paulo para a HM, além de membro acreditado do Grupo Europeu de Hipertermia Maligna. O atendimento à HM ao longo de mais de 20 anos de atividade nos tem mostrado que essa doença acomete nosso país na mesma extensão, ou talvez até mais, que outros países do mundo onde é possível investigar a HM. Entretanto, as dimensões continentais do Brasil nos impõem, a nós como médicos anestesiologistas, o desafio de combater o subdiagnóstico e a subnotificação dessa doença conhecida como o pesadelo dos anestesiologistas, mas igualmente um pesadelo para as famílias acometidas. Que a publicação desses anais do curso anual do Hotline de HM do nosso serviço, esse ano com a participação dos membros do Grupo Europeu de HM, possa servir como um impulso à divulgação da importância de conhecer e controlar a HM no Brasil.
TECHNOLOGY FOR PRODUCING COMPOSITE GLASS-CRYSTAL FACING MATERIALS BASED ON MIXED CULLET
Authors: Bondarenko N. , Puchka O. , Bessmertnyy V. , Chuev S. , Izotova I. , Bragina Lyudmila , Yalovenko T.
Published: March 2020

An effective energy-saving technology for producing composite glass-crystal facing materials based on fractionated cullet of sheet and container glasses, cullet of porcelain and sodium liquid glass has been developed. The use of fine porcelain powder in the composition of composite glass-crystal facing materials in an amount of up to 10 wt is justified. % and liquid sodium glass up to 5 wt. %. It is shown that the optimal fractional composition of granulated mixed cullet is 35 wt. % fraction 0.63-0.80 mm; 35 wt. % - fractions of 0.80-1.25 mm and 30 wt. % fraction of 1.25-3.15 mm. Polytherms of viscosity of colorless, green and brown container glasses, as well as sheet glass, are calculated. The possibility of using mixed cullet for obtaining composite glass-crystal facing materials is on the basis of obtained dependencies. The chemical composition of sheet and container glasses and porcelain is studied using x-ray fluorescence analysis. Optimal charge compositions have been developed to obtain glass-crystal materials with compressive strength up to 79 MPa. The technology of obtaining composite glass-ceramic facing material includes the following technological operations: milling of glass breakage; grinding cullet of porcelain; drying of sodium liquid glass; the screening of crushed cullet on fractions; the grind of crushed cullet of China; grinding the dried sodium silicate glass; weighing the components in accordance with the developed formulations, the averaging of the graded cullet with fine porcelain; averaging the mixture of finely ground dried sodium silicate glass; stacking the mixture in a metal mold; compaction of the mixture in metal molds; heat treatment in a muffle furnace (sintering); extraction of facing tiles from molds; trimming the edges of the tiles with a diamond saw; quality control of finished products.
APPLICATION OF ADDITIVE TECHNOLOGIES IN CONSTRUCTION AND IN THE PRODUCTION OF CERAMIC PRODUCTS
Authors: Kirillova N. , Alekseeva A. , Egorova A.
Published: March 2020

Additive technologies that allow creating volume objects of different complexity are becoming popular in different industries. There is an increase in the scale of introduction of 3D printing technologies in the construction industry, including in the production of ceramic products. With the help of modern additive technologies, different models, products and designs are created. They can be complex and can be made from different materials. Experts are wondering what the future holds for additive technologies in construction, as well as in ceramic production, as these technologies can save resources, reduce the time of the technological process and form complex shapes.

The article presents an analytical review of the global application of additive technologies in construction, as well as in the manufacture of ceramic products. The advantages and disadvantages, the possibilities of 3D printing are considered. The creation of ceramic three-dimensional products is still a rare area of additive technologies that requires research. The production of ceramic products, superior to other materials in terms of high temperature strength, hardness, chemical and thermal resistance, has a high potential for the use of additive technologies. The types of construction 3D printers and raw materials for them are analyzed. The results of a study of the properties of clay raw materials of the Sannikovsky, Namtsyrsky and Kangalassky deposits of the Republic of Sakha (Yakutia) are presented.
EXPERT ASSESSMENT METHOD IN INCREASING COMPETITIVENESS OF MACHINE-BUILDING PRODUCTS
Authors: Romancov R. , Yurakova T.
Published: March 2020

No one remembers the name of the one who came to the finish line second.

In modern realities, increasing the competitiveness of products and improving their quality are synonymous, and the search for ways to achieve these goals has become key. This article discusses the concepts of competition and presents one of the effective ways to achieve competitive products in the engineering industry - the qualimetric method of expert assessments. This method is effective, universal and convenient for solving various problems. The application of the method of expert assessments allows the company to constantly improve the shape of its products, determine the necessary quality indicators, increase the material interest of workers, improve working conditions in the workplace and much more. Thus, the method becomes an effective "tool" that allows to maintain a stable position of the enterprise on the market and provide one of the key principles of QMS, TQM - customer orientation, which includes identifying possible causes of product defects and conducting market research to determine customer needs.
APPLICATION OF THE MODAL APPROACH TO THE CONSTRUCTION OF THERMAL CHARACTERISTICS OF MACHINES OPERATING IN COMPLEX MODE
Authors: Polyakov A. , Nikitina I.
Published: March 2020

A methodology of building simulation models as applied to the thermal processes of machine tools in Simulink is presented. Three ways to building simulation models in Simulink are considered: by using the analytical solution of the thermal conductivity equation, tool for solving differential equations and apparatus of transfer functions. These three ways are presented for solving two typical problems: building the thermal characteristics of the machine tool under zero and non-zero initial conditions. Studies have shown that Simulink allows to build models with simple logic, but the advantage of the built S-models is their visibility and structuring. When modeling the diagrammatic works of the machine’s operation, the method of building simulation models based on the use of analytical solutions of the thermal conductivity equation allows to build the most compact models. A feature of building invariant models in Simulink is the use of the Matlab m-file, in which the parameters used in the S-model are generated.
THE IMPORTANCE OF THE USE OF WARM MIX ASPHALT FOR CONSTRUCTION ROADS IN CONDITIONS OF THE SYRIAN ARAB REPUBLIC
Authors: Alshahwan A. , Kalgin Yu.
Published: March 2020

As a result of prolonged hostilities in the Syrian Arab Republic, maintenance and repair of roads are not carried out for a long time, which led to the decline of the road network. Roads of the Syrian Arab Republic require significant rehabilitation; repairs must be carried out within a short period at the lowest cost, while achieving optimal technical characteristics. Weak economic potential of the country, low fuel reserves of various types, in addition to the huge destruction of the road network - all these difficulties facing the reconstruction process. This article is devoted to the study of the characteristics of the technologies of asphalt mixes used in road construction, and the determination of the most suitable technology for current conditions. As a result of research, it is emphasized that warm asphalt mix is the best choice compared to other types of technologies: it reduces energy consumption, reduces production costs, helps to extend the construction season, expand production capacities, save the environment, etc.
EXPERIMENTAL STUDIES OF THE KINETICS OF THE DEVELOPMENTAL CORROSIVE DAMAGES OF CONCRETE IN BENT REINFORCED CONCRETE ELEMENTS UNDER FORCE AND ENVIRONMENTAL EFFECTS
Authors: Frolov N.
Published: March 2020

The article deals with the main aspects of the development of concrete corrosion damage in reinforced concrete structures. It is noted that the main quantitative indicators of such damages are the depth and the damage factor. Their change in time characterizes the kinetics of the development of concrete corrosion damage. The kinetic model of corrosion damage development by V.M. Bondarenko is presented as perspective for inclusion into normative documents. For the purpose of its additional substantiation special experimental studies of loaded samples of reinforced concrete beams and non-loaded samples in the form of concrete cubes and prisms under prolonged exposure to sulfate- and chloride-containing aggressive media have been conducted. New experimental data on peculiarities of accumulation of corrosive damages of concrete taking into account the influence of different operational factors have been obtained. It is established that damage development has a pronounced fading character over time and depends on the type of operating medium, the presence of cracks, the sign and level of stresses acting in the concrete. In case of sulfate corrosion, the damage coefficient of the outer layer of concrete in the transition zone does not take into account the value equal to zero. It is concluded that the adopted model quite reliably describes the development of corrosive damages of concrete in these corrosive environment.
RELAXATION PROPERTIES OF COMPOSITE MATERIALS BASED ON MIXTURES OF EPOXY POLYMERS AND THERMOPLASTIC ELASTOMERS
Authors: Kochergin Y. , Grigorenko Tatyana , Zolotareva V.
Published: March 2020

The influence of thermoplastic elastomers, which are two-block statistical block copolymers based on polybutylene terephthalate and polytetramethylene oxide with a different ratio of rigid and elastic blocks, on the static and dynamic mechanical properties of epoxy polymers is studied. The initial compounds for the synthesis of block copolymers are dimethyl terephthalate, 1,4-butanediol and polytetramethylenoxide with a molecular weight of 2000. The tetrabutoxide is used as catalyst. The process of interaction of the initial components is carried out in two stages, the reaction of transesterification and copolycondensation is consistently carried out. The composition of BSP is set by the ratio of initial reagents. The total molecular weight of block copolymers is 30–40 thousand. The method of dynamic mechanical analysis shows that the introduction of modifiers leads to a decrease in molecular mobility in a wide temperature range from low-temperature (at 220K) to high-temperature (at 380K) relaxation transitions. The magnitude of the effect depends on the ratio of rigid and flexible blocks in the block copolymer. It is assumed that the decrease in the tangent of the angle of mechanical losses at temperatures below the glass transition temperature and especially in the region of the β-transition, may be associated with the slowdown of relaxation processes at the interface of the epoxide matrix with rigid blocks of thermoplastic elastomer. The observed effects in the region of high-temperature transition may be associated with the restriction of freedom of conformational rearrangements near the interface of the epoxy polymer with polybutylene terephthalate and polytetramethylene oxide blocks and an increase in the cross-linking density of the epoxy. A noticeable decrease in the magnitude and creep rate of epoxy composites is found when thermoelastoplast is introduced.
Mímesis sonora y metamorfosis estética: el siglo XIX como estadio crítico en la historia del pensamiento musical
Authors: Campos Calvo-Sotelo Javier
Published: March 2020

La teoría de la afinidad sónica (Campos, 2016) considera que el cerebro musical humano está modelado por la acción de sonidos recibidos desde la formación del oído, generando perfiles sonoros y estéticos en procesos miméticos integrados en la lógica evolutiva. Aplicada al ámbito de la musicología histórica, permite analizar el siglo XIX como estadio determinante de mutaciones musicales a raíz de la revolución industrial, que aplastó la quietud sonora del Antiguo Régimen con el estruendo de las máquinas de vapor, las hilanderas mecánicas y el ferrocarril. La orquesta creció imparable, el piano duplicó en potencia y posibilidades a sus predecesores, el metrónomo y la pianola se universalizaron, y las composiciones cultas desarrollaron unos rasgos y complejidad impensables anteriormente. Asimismo, la voz humana se ahogó temporalmente bajo la avalancha instrumental.
Pengaruh Kepemimpinan Transformasional Terhadap Kepuasan Kerja Karyawan Dimediasi Oleh Keadilan Organisasi Pada RSIA Cahaya Bunda Cirebon
Authors: Sylvani Sylvani , Jufri Ali , Qodriah Sari Laelatul
Published: March 2020

ABSTRACT

 

Health in the modern era is now an inseparable necessity from the development of healthy and smart Indonesian people. Hospitals as one of the health facilities that provide health services to the community have a very strategic role in accelerating the improvement of community health status. Therefore, hospitals are required to provide quality services in accordance with established standards and can reach all levels of society. For this reason, the need for synergy between leaders and employees. Employees still complain about the way leaders handle each employee's complaints, such as complaints of discrepancies between salaries and work performed, employees still feel discriminated in the sense of being discriminated according to social status, the length of the process of determining to become permanent employees, and so forth. From the factors mentioned above that the role of the leader in leading must be wise and fair both for the organization and employees in the organization.

This study aims to obtain empirical evidence of whether or not the influence of transformational leadership on job satisfaction is mediated by organizational justice. This study used a correlational quantitative method and the data processing was assisted with SPSS 22. The population of this study was all employees of RSIA Cahaya Bunda including permanent employees and contract employees while the study sample was only 127 permanent employees. Determination of samples using Slovin formula. The results of this study indicate that transformational leadership has a direct positive effect on job satisfaction, organizational justice has a positive effect on job satisfaction, transformational leadership has a positive effect on organizational justice and organizational justice is able to mediate the relationship between transformational leadership and job satisfaction.

 

Keywords: transformational leadership, job satisfaction, organizational justice, hospital.
MASYARAKAT BELI PRODUK ROTI TERNAMA KARENA CITRA TOKO ATAU KUALITAS PELAYANAN?
Authors: Nusannas Iman Sidik
Published: March 2020

The study was to determine the effect of Store Image and Service Quality on Consumer Buying Interest at a famous bakery at Purwakarta. The datas taken from respondents that was questionnaired to 96 respondents with Non Probability Sampling techniques. The research method used is descriptive method which is a method that is done by collecting, presenting and analyzing data so as to provide a clear enough picture of the object under study. This study uses a multiple linear regression analysis model with the help of IBM SPSS 21 program. The results of this study indicate that the variables of Store Image and Service Quality have a positive and significant effect on Consumer Interest in a famous bakery at  Purwakarta.
FAKTOR-FAKTOR YANG MEMPENGARUHI MINAT NON MUSLIM MENJADI NASABAH BANK SYARIAH DI TASIKMALAYA
Authors: Marlina Lina
Published: March 2020

This research is intended to find out what factors are causing non-Muslims to become customers of Islamic banks. The study was conducted at the BNI Syariah branch of Tasikmalaya. The method used in this research is quantitative research methods. The results of the study show that: (1) Location partially does not affect the interest of non-Muslims to become customers at BNI Syariah Tasikmalaya Branch. This is indicated by the t test which obtained the value of tcount <ttable (1.090 <1.657); (2) Service partially has no effect on the interest of non-Muslims being customers at BNI Syariah Tasikmalaya Branch. This is indicated by the t test obtained -count> -table (-1,055> -1,657). 3. Religious stimuli partially has no effect on the interest of non-Muslims becoming customers at BNI Syariah Tasikmalaya Branch. This is indicated by the t test which obtained the value of -count> -table (-0.586> -1.657); (3) Reputation Partially does not affect the interest of non-Muslims to become customers at BNI Syariah Tasikmalaya Branch. This is indicated by the t test which obtained the value of -count> -table (-0.448> 1.657); (4) Profit sharing Partially has no effect on the interest of non-Muslims becoming customers at BNI Syariah Tasikmalaya Branch. This is indicated by the t test which obtained the value of -count> -table (-0.630> -1.657); (5) Promotion partially affects the interest of non-Muslims being customers at BNI Syariah Tasikmalaya Branch. This is indicated by the t test obtained t value> t table (2.571> 1.657); (6) Location, service, religious stimuli, reputation, profit sharing, and promotion simultaneously do not affect the interest of non-Muslims to become customers at BNI Syariah Tasikmalaya Branch. This is indicated by the F test which obtained the calculated F value <F table (1.619 <2.17).