bluuebunny/crossref_metadata_2025 huggingface dataset:
Utilizing the Delphi Method for Selecting Smart Quality Key Factors in the Manufacturing Context
Authors: Silitonga Riana Magdalena , Sukwadi Ronald , Sejahtera Surbakti Feliks Prasepta , Lin Ming-Chang , Jou Yung-Tsan
Published: May 2024

The quality of products and services used in global marketplaces is critical. Manufacturing companies can compete in international marketplaces by leveraging quality effectively to outperform competition. Industry 4.0, a plan promoted by industrialized countries, has resulted in implementing "smart manufacturing," which places a premium on quality control. As a result of improved quality control enabled by new technology, the industrial sector has been changed. Nonetheless, smart quality implementation is still in its early stages, and more empirical study is needed to understand its benefits and drawbacks fully. A survey will be developed to assess how people perceive smart quality awareness and manufacturers' readiness to embrace Smart Quality. This study applied Delphi methodology to investigate the critical factors and particular indicators of implementing the Smart Quality model in manufacturing organizations. Experts from academics and business management analysed the Delphi approach and discovered eight factors and sixteen indicators. The findings will lead to a new method for assessing Smart Quality.
Distributed Digital Enterprise Architecture for Transformation of Educational Organizations
Authors: Srisawat Surasak , Wannapiroon Panita , Nilsook Prachyanun
Published: May 2024

Enterprise architecture is of essential significance for organizations currently adapting to the digital transformation era. It is the application of modern digital technology in various organizational departments to drive efficiency. This research presents the development of a distributed digital enterprise architecture framework for education organizations that have applied the enterprise architecture concepts of The Open Group Architecture Framework, Zachman, and the Federal Enterprise Framework using an online questionnaire as a tool to collect data from 520 samples. The results revealed that the distributed digital enterprise architecture for education organizations is divided into seven dimensions: business architecture, data architecture, application architecture, technology architecture, security architecture, human capital architecture, and infrastructure architecture. The experts’ evaluation of the architecture found that the overall appropriateness was at the highest level in all aspects. The research results indicate that enterprise architecture is essential for systematically integrating digital technology with an organization’s workflow or mission for it to become a distributed digital enterprise.
Development of Photovoltaic Systems and Application in Smart Grids: Sivas Case
Authors: Yılankırkan Nazile , Baytar Büşra Cin
Published: May 2024

The high solar energy potential in Turkey is an important advantage and the effective utilization of this potential will contribute to the national economy. In this study, the integration of photovoltaic systems (PVs) with smart grids, which are becoming increasingly important in terms of ensuring energy efficiency, is examined. Within the scope of the study, a village with 30 households in Sivas province was designed and the amount of electrical energy that 30 households will need per day was calculated based on the daily energy consumption of each household in the village. Then, a photovoltaic (PV) consisting of 60 panels of 675 Wp (Watt-peak) was designed to meet this need. The PV was integrated into the city grid to meet the electrical energy needs of this village even when the PV was insufficient. For this integration to work without interruption, control technologies were added to the integration and simulated in MATLAB/Simulink environment. With the designed PV, it is seen that the entire electrical energy need of the village can be met between April and September, and a significant part of this need can be met between October and March, and the remaining part can be supplied from the grid thanks to the integration.
Influence of leptin administration to pregnant mice on fetal gene expression and adaptation to sweet and fatty food in adult offspring of different sexes
Authors: Denisova E. I. , Makarova E. N.
Published: May 2024

Elevated leptin in pregnant mice improves metabolism in offspring fed high-calorie diet and its influence may be sex-specific. Molecular mechanisms mediating leptin programming action are unknown. We aimed to investigate programming actions of maternal leptin on the signaling function of the placenta and fetal liver and on adaptation to high-calorie diet in male and female offspring. Female C57BL/6J mice received leptin injections in mid-pregnancy. Gene expression was assessed in placentas and in the fetal brain and liver at the end of pregnancy. Metabolic parameters and gene expression in the liver, brown fat and hypothalamus were assessed in adult male and female offspring that had consumed sweet and fatty diet (SFD: chow, lard, sweet biscuits) for 2 weeks. Females had lower blood levels of leptin, glucose, triglycerides and cholesterol than males. Consuming SFD, females had increased Ucp1 expression in brown fat, while males had accumulated fat, decreased blood triglycerides and liver Fasn expression. Leptin administration to mothers increased Igf1 and Dnmt3b expression in fetal liver, decreased post-weaning growth rate, and increased hypothalamic Crh expression in response to SFD in both sexes. Only in male offspring this administration decreased expression of Fasn and Gck in the mature liver, increased fat mass, blood levels of glucose, triglycerides and cholesterol and Dmnt3a expression in the fetal liver. The results suggest that the influence of maternal leptin on the expression of genes encoding growth factors and DNA methyltransferases in the fetal liver may mediate its programming effect on offspring metabolic phenotypes.
mRNA-lncRNA gene expression signature in HPV-associated neoplasia and cervical cancer
Authors: Kulaeva E. D. , Muzlaeva E. S. , Mashkina E. V.
Published: May 2024

Cervical cancer is one of the most frequent cancers in women and is associated with human papillomavirus (HPV) in 70 % of cases. Cervical cancer occurs because of progression of low-differentiated cervical intraepithelial neoplasia through grade 2 and 3 lesions. Along with the protein-coding genes, long noncoding RNAs (lncRNAs) play an important role in the development of malignant cell transformation. Although human papillomavirus is widespread, there is currently no well-characterized transcriptomic signature to predict whether this tumor will develop in the presence of HPV-associated neoplastic changes in the cervical epithelium. Changes in gene activity in tumors reflect the biological diversity of cellular phenotype and physiological functions and can be an important diagnostic marker. We performed comparative transcriptome analysis using open RNA sequencing data to assess differentially expressed genes between normal tissue, neoplastic epithelium, and cervical cancer. Raw data were preprocessed using the Galaxy platform. Batch effect correction, identification of differentially expressed genes, and gene set enrichment analysis (GSEA) were performed using R programming language packages. Subcellular localization of lncRNA was analyzed  using Locate-R and iLoc-LncRNA 2.0 web services. 1,572 differentially expressed genes (DEGs) were recorded in the “cancer vs. control” comparison, and 1,260 DEGs were recorded in the “cancer vs. neoplasia” comparison. Only two genes were observed to be differentially expressed in the “neoplasia vs. control” comparison. The search for common genes among the most strongly differentially expressed genes among all comparison groups resulted in the identification of an expression signature consisting of the CCL20, CDKN2A, CTCFL, piR-55219, TRH, SLC27A6 and EPHA5 genes. The transcription level of the CCL20 and CDKN2A genes becomes increased at the stage of neoplastic epithelial changes and stays so in cervical cancer. Validation on an independent microarray dataset showed that the differential expression patterns of the CDKN2A and SLC27A6 genes were conserved in the respective gene expression comparisons between groups.
La vivienda tradicional nahua en la Sierra Norte de Puebla y su proceso de transformación
Authors: García-Navarro María José , Ramírez Valverde Benito , Juárez Sánchez José Pedro , Cesin Vargas José Alfredo , Bustamante González Angel
Published: May 2024

La vivienda indígena es una manifestación arquitectónica que devela los valores, la identidad y los modos de habitar estos grupos, expresados mediante su composición, materiales y técnicas de construcción locales, que mantienen rasgos prehispánicos. Como resultado de la modernidad y de procesos de transculturización, la vivienda se encuentra en un fuerte proceso de transformación. Esta investigación se realizó en la comunidad nahua de San Miguel Tzinacapan, Cuetzalan, en la región Sierra Norte de Puebla, con el objetivo de conocer su estado actual y profundizar en su proceso de transformación con una clasificación que muestra su composición y una línea del proceso de cambio sufrido. El método usado en esta investigación fue a partir del análisis arquitectónico en la comunidad de una muestra estadística conformada por de 104 viviendas. Se encontró que la composición espacial se ha modificado, aunque casi la mitad de éstas aún mantienen materiales y técnicas locales, no obstante, el uso de insumos industrializados se ha masificado, pues solo 19% está construida con materiales naturales, 43% es mixta, y 38% se considera vivienda moderna. Se concluye que la vivienda es un elemento cultural que se encuentra en un constante proceso de adaptación y reapropiación como resultado de una nueva manera de relacionarse, manteniendo los valores sociales de la comunidad.
Un exemple d'emploi des engins mécaniques de terrassement en exploitation forestière tropicale
Authors: De Muizon P.
Published: May 2024

L'une des principales entreprises forestières du Gabon (Afrique Equatoriale Française), la C.F.B.G., doit très souvent être en mesure d'effectuer, dans des délais très courts, des travaux de terrassement très importants, afin de construire la voie ferrée pour le transport des grumes dans une région où la main d'oeuvre manque cruellement. Cette entreprise a réalisé, depuis un certain temps, tous les travaux de terrassement, au moyen d'engins mécaniques, tels que bulldozer, scraper et autres.
Bien qu'aujourd'hui ces engins ne soient plus considérés comme nouveaux, il est intéressant de noter que dans un cas concret d'exploitation de la forêt tropicale, les résultats ont été décisifs bien que l'utilisation de ces engins n'ait été nécessaire que quelques mois par an.
La conférence forestière inter-africaine d'Abidjan
Authors: Perriguey N.
Published: May 2024

Cette Conférence, réunie sous les auspices du Comité Technique de Coopération au Sud du Sahara (Afrique), s'est tenue du 4 au 12 décembre 1951, à Abidjan, chef-lieu de la Côte d'Ivoire (Afrique Occidentale Française).
La réunion comprenait des représentants des 4 gouvernements membres de ce Comité (Belgique, Portugal, Royaume-Uni, France), ainsi que diverses personnalités d'autres pays concernés par les problèmes de la foresterie tropicale.
Le but de la Conférence était d'étudier la ligne de conduite générale à adopter pour les questions concernant la politique forestière, la sylviculture et les organisations sylvo-agricoles et sylvopastorales.
Cette réunion a permis de constater l'existence d'une parfaite homogénéité d'opinion entre les différents pays sur les problèmes forestiers. La Conférence a ensuite décidé des recommandations concernant les problèmes étudiés.
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Predictive Factors of Time Die From COVID-19 in Intensive Care Units
Authors: Bergonzoli Gustavo , Tinoco Zapata Felipe Jose , Jaramillo Carolina , Rodriguez Christian Jhoan
Published: May 2024

To identify risk factors that increase or decrease the probability of dying from Covid-19 in Intensive Care Units (ICU) patients. This study is based on data collected retrospectively from the hospital records. The proportional model assumption was verified using the Kaplan–Meier method, and Cox Hazard Proportional Regression model to identify predictors’ factors associated with time to death by Covid-19. Four factors were identified, two of them increase the probability of dying: age (Adjusted Hazard Ratio (HRa) = 1.032 (1.022–1.041), and breathing frequency HRa = 1.035 (1.016-1.054), and two decrease the probability: lymphocytes HRa = -0 815 (0.674–0.985), and diastolic pressure HRa = -0.992 (0.986–0.998). Every five years of increase in age the probability of dying does the same by 13.5%; while with an increase of three breaths there is an increase in the probability of dying equal to 7.4%. At the same time, five ml increase in mercury pressure will decrease mortality probability by 1.6%, while a 1.5 increase in lymphocytes will decrease it by 7.9%.  Knowing these factors will undoubtedly be a useful tool to identify those patients who, due to their clinical condition, have a morbidity profile that classifies them as very high risk of dying, and therefore deserve personalized medical care.
The Relationship Between Energy Drinks A and B with Blood Pressure and Pulse Rate Increase Among College Students
Authors: Setiabudi Narendra Arya
Published: May 2024

Energy drinks are popular among various groups of people, such as teenagers and working individuals. These beverages are consumed to provide additional energy and improve focus. This research investigates the relationship between energy drinks and blood pressure and heart rate in students of the Faculty of Medicine at Universitas Airlangga, Surabaya, Indonesia. The study used the open trial – randomized cross-over study method and collected primary data through experiments. The sample consisted of students from the Faculty of Medicine at Universitas Airlangga, aged 19 to 22 years, with a normal body mass index ranging from 18.5 to 24.9. The systolic, diastolic, and heart rate values were measured before and after consuming energy drinks. A total of 38 research samples were used, including 22 males (57.8%) and 16 females (42.1%). Energy drinks such as Kratingdaeng and Extra Joss showed a significant increase in blood pressure. However, no significant changes were observed in heart rate. The results of the Wilcoxon statistical test, comparing systolic and diastolic conditions before and after consuming Extra Joss, showed p<0.0001. A significance level of p<0.05 indicates a significant effect of energy drinks on the students. The Wilcoxon test for Kratingdaeng also yielded a p<0.0001. For the p-value through the Wilcoxon test on diastolic values before and after consuming Extra Joss and Kratingdaeng, the result was p<0.05. However, the Wilcoxon test for heart rate before and after consuming Kratingdaeng and Extra Joss had a at p<0.05. In the Mann-Whitney statistical test, a p<0.05 was found only in the post-systolic condition, while other conditions had at p≥0.05. In conclusion, energy drinks significantly affected blood pressure, but no significant changes were observed in heart rate.
Reduced protein kinase C delta in a high molecular weight complex in mitochondria and elevated creatine uptake into Barth syndrome B lymphoblasts
Authors: Mejia Edgard M. , Sparagna Genevieve C. , Miller Donald W. , Hatch Grant M.
Published: May 2024

Aim: Barth syndrome (BTHS) is a rare X-linked genetic disease in which mitochondrial oxidative phosphorylation is impaired due to a mutation in the TAFAZZIN gene. The protein kinase C delta (PKCδ) signalosome exists as a high molecular weight complex in mitochondria and controls mitochondrial oxidative phosphorylation.

Method: Here, we examined PKCδ levels in mitochondria of aged-matched control and BTHS patient B lymphoblasts and its association with a higher molecular weight complex in mitochondria.

Result: Immunoblot analysis of blue-native polyacrylamide gel electrophoresis mitochondrial fractions revealed an increase in total PKCδ protein expression in BTHS lymphoblasts compared to controls. In contrast, PKCδ associated with a higher molecular weight complex was markedly reduced in BTHS patient B lymphoblasts compared to controls. Given the decrease in PKCδ associated with a higher molecular weight complex in mitochondria, we examined the uptake of creatine, a compound whose utilization is enhanced upon high energy demand. Creatine uptake was markedly elevated in BTHS lymphoblasts compared to controls.

Conclusion: We hypothesize that reduced PKCδ within this higher molecular weight complex in mitochondria may contribute to the bioenergetic defects observed in BTHS lymphoblasts and that enhanced creatine uptake may serve as one of several compensatory mechanisms for the defective mitochondrial oxidative phosphorylation observed in these cells.
Lower hepatic CBS and PEMT expression in advanced NAFLD: inferencing strategies to lower homocysteine with a mathematical model
Authors: Suzuki Ayako , Henao Ricardo , Reed Michael C. , Nijhout H. Frederik , Tripathi Madhulika , Singh Brijesh Kumar , Yen Paul Michael , Diehl Anna Mae , Abdelmalek Manal F.
Published: May 2024

Aim: Hepatic homocysteine (Hcy) accumulation promotes inflammation and fibrosis in experimental nonalcoholic fatty liver disease (NAFLD), while vitamin B12 and folate reduce hepatic Hcy and protect animals from nonalcoholic steatohepatitis. This suggests clinical implications for preventing/treating patients with NAFLD. Given the known sex-specific regulation of one-carbon metabolism (OCM), the response to various OCM cofactors may vary by sex and reproductive status. We aimed to strategize an effective Hcy-lowering treatment in broader NAFLD patients while discerning disparities in treatment responses.

Methods: We analyzed existing hepatic microarray data relevant to Hcy metabolism with clinical and histologic data from patients with NAFLD (N = 82), while considering potential age/sex disparities. Additionally, we performed computer simulation analyses using a mathematical model of OCM to predict hepatic Hcy-lowering effects of OCM cofactors by sex.

Results: Of 82 patients with NAFLD, 98% had at least one metabolic feature [i.e., metabolic dysfunction-associated steatotic liver disease (MASLD)]. Lower hepatic gene expressions of cystathionine-beta synthase (CBS ) and phosphatidyl- ethanolamine N-methyltransferase (PEMT ) were associated with more severe fibrosis in NAFLD, while sub-analysis suggested possible variations by age and sex. The simulation analysis demonstrated sex differences in the Hcy-lowering effects of the OCM cofactors (vitamins B6 and B12, folate, and betaine), with the combination of these cofactors consistently showing the maximum Hcy-lowering effect in both sexes.

Conclusion: We theorize that the combination of OCM cofactors would maximize Hcy-lowering effects in the broader MASLD population. Our findings also underscore the importance of considering sex and age in designing future studies on homocysteine metabolism.
An Emerging Concentric Spatial Turn for Sustainable Systems: Beyond the Diametric Spatial Frame in Bacon’s View of Humans as Apart from and Above the Natural World Towards Being-Alongside Nature
Authors: Downes Paul
Published: May 2024

A spatial turn is increasingly being recognised across education, the humanities and social sciences to critique Western Cartesian assumptions treating space as either empty or a diametric opposition bringing dualistic splits between reason/emotion, and mind/body. Bacon’s vision of human subjugation of nature as a tool for human progress is examined as a diametric spatial projection, where humans are above and apart from nature, in a mirror image inverted symmetry of above/below hierarchy and side-by-side assumed separation as diametric space.
Building on an interdisciplinary synthesis between an aspect of the structural anthropology of Lévi-Strauss, De Beauvoir’s othering and Bronfenbrenner’s social-ecological systems in psychology, allied with a Heideggerian critique of being as needing a mode of ‘being alongside the world’, a shift in experiential and conceptual space is proposed in this conceptual review article for education. This shift is towards a framework of concentric spatial systems of sustainability. Concentric relational spaces of assumed connection and relative openness and away from diametric spaces of splitting and closure have been developed recently for sustainability concerns regarding inclusion in education. This article goes further to interrogate systems of concentric relational space for belonging with and encountering the natural world for environmental sustainability.
Evaluation of Dunaliella salina Growth in Different Salinities for Potential Application on Saline Wastewater Treatment and Biomass Production
Authors: Tanoeiro João Rui de Azevedo Godinho Pereira , Fehrenbach Gustavo Waltzer , Murray Patrick , Pedrosa Rui , Chen Yuanyuan
Published: May 2024

This study investigated the adaptability of Dunaliella salina to different salinity levels, with emphasis on growth, pigment concentration, and desalination potential. It was found that among the 21 salinity levels, salinity 75 produced consistently favorable results in cell count (13.08 x 103 ± 1.41 x 103 cells/mL), dry biomass (2.46 ± 0.06 g/L), pigment content (chlorophyll a = 97.5 ± 0.1 µg/L, chlorophyll b = 123.6 ± 0.3 µg/L), and desalination (9.32 ± 0.47 reduction). Therefore, salinity 75 was selected for the final trial (scale-up), which revealed unanticipatedly high cell counts (58.96 x 103 ± 535.22 cells/mL), with dry biomass weight being statistically different (higher) than the expected (4.21 ± 0.02 g/L) (p<0.0001), most likely due to high cell count and energy reserve storage for high salinity adaption in the form of bio-compounds. Pigment growth continued (chlorophyll a = 95.4 ± 2.2 µg/L, chlorophyll b = 128.1 ± 5.1 µg/L), indicating pigment production under salt stress. Notably, desalination did not occur in this stage, possibly due to the necessity for a bigger initial inoculate, prolonged exposure or bioaccumulation becoming the prevailing mechanism over desalination. Nevertheless, the trial highlights D. salina's strong adaptation to various salinity levels. This suggests a promising future in halophyte research, particularly in understanding the mechanisms that prevent salt accumulation in cells and how to overcome this barrier. Additionally, these results suggest that microalgae could be a viable resource in saline-rich environments unsuitable for conventional agriculture, promoting industrial adaptation to adverse conditions.
The Existence and Construction of Palindrome Numbers Divisible by 37
Authors: Jiang Fan
Published: May 2024

The existence of palindrome numbers of arbitrary length greater than 2 that are divisible by the prime number 37 is proven in this paper. The method to construct such a palindrome is also described. It turns out that a palindrome number divisible by 37 is also divisible by 3 and, consequently, divisible by 111.
Integrating Curriculum, Extracurricular Activities, and Community Engagement: A Study on Under Graduates Awareness, Sustainable Environmental Education, and Well-Being in Higher Education
Authors: Sharma Dr Renu , Vinodkumar Nisa , Almoudhan Weasam
Published: May 2024

Higher education equips youth with the requisite knowledge and skills for navigating environmental education and sustainability. The current study aims to test a comprehensive model for integrating environmental education and sustainability principles within the higher education ecosystem. The model emphasizes problem-based and service-learning approaches, technological integration, and behaviour change models to foster environmental education, and community engagement and enhance overall well-being. In this study, researchers examined the impact of curriculum, extracurricular activities, and community engagement as independent variables on dependent variables namely environmental education, sustainability, and well-being while also considering the mediating role of the undergraduates' awareness level. Data was collected from a higher education academic Institute in Riyadh, Saudi Arabia. The variance-based structural equation modeling (SEM) technique using Smart-Partial Least Squares (PLS) software was used to test these hypothesized relationships empirically. The study findings revealed a significant positive impact of curriculum development, extracurricular activities, and community engagement efforts on elevating undergraduates' awareness levels. Awareness levels mediated the effect of environmental education, sustainability, and well-being, highlighting the need to integrate environment-related topics into academic and extracurricular activities. This underscores higher education's potential to shape eco-conscious leaders by infusing environmental education into academic life. These findings have implications for higher education institutions, policymakers, and community organizers, emphasizing the importance of a holistic approach to environmental education for a sustainable society. By fostering environmental awareness among youth and integrating it into broader societal initiatives, educational institutions can play a crucial role in shaping a generation committed to sustainability and well-being.
Association between Dietary Saturated Fat and Telomere Length: The National Health and Nutrition Examination Survey (NHANES)
Authors: Ziperovich Jason
Published: May 2024

This study examines the association between dietary saturated fatty acid (SFA) intake and leukocyte telomere length (LTL) using data from the National Health and Nutrition Examination Survey (NHANES) 1999-2002. Telomeres, protective repeats of DNA at the ends of chromosomes, play a crucial role in cellular aging. Their length is shortened over time and is influenced by various factors, one of which is diet. The present study's objective was to evaluate whether increased SFA consumption is associated with shorter LTL. The analysis, conducted on a large, nationally representative sample of 6646 adults, revealed an inverse association between dietary SFAs and LTL. When examined further, this association was found to be significant in women, but not in men. Serum C-reactive protein (CRP) levels were tested as a potential mediator in this relationship, but no such mediation was found. These findings support the role of dietary factors in modulating cellular aging. However, further research is warranted to elucidate the underlying mechanisms driving the overall association, as well as the gender-specific effects observed.
Penerapan Modul Elektronik Sigil untuk Meningkatkan Kompetensi Pengetahuan dan Kemampuan Representasi Grafik Siswa
Authors: Amelia Fariza , Ekawati Elvin Yusliana , Fauzi Ahmad
Published: May 2024

This study aims to: (1) Describe the improvement of knowledge competence of students in class XI MIPA 2 SMA Negeri 5 Surakarta in the 2021/2022 academic year through the application of the Sigil electronic module, (2) Describe the improvement of the graphic representation ability of students in class XI MIPA 2 SMA Negeri 5 Surakarta in the 2021/2022 academic year through the application of the Sigil electronic module. The research design used is class action research (PTK) using the Kemmis and Mc. Taggart model and organized in two cycles. The data collection technique used interviews, tests, documentation and document review techniques. Data analysis techniques used qualitative and quantitative analysis. Data validity techniques used instrument validity and triangulation techniques. The results showed that the application of the Sigil electronic module based on Saintifik on the material Elasticity and Hooke's Law can improve the knowledge competence and graphic representation skills of students in class XI MIPA 2 SMA Negeri 5 Surakarta in the 2021/2022 academic year. The percentage of knowledge competency completeness increased from 35.29% in the pre-cycle stage, to 61.76% in cycle I, and reached 100% in cycle II. The percentage of achievement on each indicator of students' graphic representation ability also increased from 4 indicators achieved in cycle I, then in cycle II all indicators reached the research target.
Analisis Hasil Belajar Siswa dalam Pembelajaran Problem Based Learning (PBL) Materi Kinematika Gerak Lurus
Authors: Azzahra Maura , Jumini Sri , Ariyanto Agus , Hamzah H
Published: May 2024

The aim of this research is to determine the improvement in physics learning outcomes in the kinematics of rectilinear motion material and student responses to the application of the Problem Based Learning (PBL) learning model in the learning process. This research is included in the type of Classroom Action Research (PTK). The subjects in this research were students of class XI Science 4 MA Negeri 1 Wonosobo for the 2023/2024 academic year with a total of 36 students. This research resulted that the overall percentage of individual completeness increased from cycle 1 to cycle II, namely from 55.6% to 78% and the overall percentage of classical completeness also increased, namely from 60% to 80%. Student responses tend to be positive where students state they are happy with the learning process using the Problem Based Learning (PBL) learning model. This research can be concluded that the application of the Problem Based Learning (PBL) learning model can improve the physics learning outcomes of class XI IPA 4 MA Negeri 1 Wonosobo students on the Kinematics of rectilinear motion material
Newton's Law Learning Transformation: Interactive Android Application with Adobe Flash Professional CS6
Authors: Haj Mochammad Irsyadul , Fauzi Ahmad , Budiawanti Sri
Published: May 2024

This study describes the product specifications and user assessment of Android-based physics learning media using Adobe Flash Professional CS6 with a scientific approach to Newton's Law material that is well-criteria in language, material, and media. This research and development uses a qualitative descriptive analysis approach developed by Branch (2009). Data analysis uses analysis techniques developed by Azwar (2007). The procedure for making this learning media is to Analyze, Design, and Develop. The results of this study are in the form of a learning media with (1) Physics learning media made is an android application-based learning media with the extension Application Package (.apk) with minimum specifications OS (Operating System) android v 7.0 Nougat, Snapdragon 435 chipset and CPU Octa-core Max 1.40GHz, with a minimum of having 2 GB RAM, 2 GB ROM, and 480 x 800 resolution. Physics learning media based on the material and lesson plans of Newton's Law material with a scientific approach. Physics learning media contains Learning, Material, Evaluation, and Settings pages with features such as simulation, movie clips, video, UI, scrolling text, swipe gallery, drag and drop, sound, and without internet (offline). (2) The physics learning media made has a validation value on the basha aspect of 43, the material of 71, and media 71, so the learning media validation value is 185 with a very good category. The physics learning media has an assessment response value from 3 teachers, namely 100% of teachers stated very well, and the assessment response value from 30 students, namely, 23% of students stated in the good category and 77% stated in the very good category. This research can be the basis for developing interactive android application with Adobe Flash Professional CS6 for Newton's Law material.
Development of Electronic Physics Modules with a Scientific Approach Using the Lectora Inspire Application in Static Fluid Materials
Authors: Pasha Atika Sella Wulandari , Suharno Suharno , Fauzi Ahmad
Published: May 2024

This research aims to scientifically develop a Physics-based electronic module approach using the Lectora Inspire application on Static Fluid material, knowing the feasibility of the electronic module being developed. The type of research used is R&D (Research and Development), with development procedures using the ADDIE model. However, the procedures carried out only reached the third stage: analysis, design, and Development. The data used in this research are qualitative and quantitative data obtained from research subjects. The analysis stage is carried out by analyzing the needs of teachers and students in Physics learning activities. The design stage is the design of compiling electronic modules according to the results of the needs analysis. The development stage was validated by two expert lecturers as expert validators, three teacher validators (users), and trials by students consisting of 3 students in one-on-one trials, nine students in small group trials, and 96 students in field trials. Product feasibility is obtained based on validation results from expert validators, teacher validators (users), and student trials. The data collection techniques used were documentation and questionnaires, which were analyzed based on Azwar's opinion. Based on the results of the research and discussion, it can be concluded that the results of expert validation obtained an average score of 110, teacher validation of 108.6 from a maximum score of 116, and the average score of one-on-one trial results was 21.33, the average of small group trials was 22.11, and the average of field trials was 23.05 so that The developed electronic module meets criteria very good. Hence, it is very suitable for use in high school learning.
The Tasawwuf As the Character Education Solution in Indonesia
Authors: Suharyat Yayat , Resky Muhammad , Soltani Beya , Ali Madi Ahmed Abdelraziq
Published: May 2024

The research aims to analyse the importance of Sufism values as a solution and improvement of character education in Indonesia. The research method used is a qualitative method with a literature study approach. The data collected in this study were books and journals analysed using the content analysis method. Data analysis was conducted qualitatively through description, reduction, categorisation, and interpretation. This research has shown the importance of Sufism values used in the education and learning system to grow students' moral skills at school. Sufism values are very relevant to the substance of the teachings of the Qur'an and Sunnah to control morals. This research is expected to have implications for systematic efforts in fostering and instilling the character values of piety in students through social behaviour and spiritual attitudes as a provision for life.
The Extended Theory of Planned Behavior to Measure Sharia Investment Intention Among the Z Generation
Authors: Fahmi Much. Maftuhul , Suprayitno Eko , Yuliana Indah , Ekowati Vivin Maharani , Rofiq Aunur
Published: May 2024

This study examines Generation Z's sharia investment preferences in light of Islamic financial literacy and religion. The Theory of Planned Behavior (TPB) was utilized to analyze attitudes, subjective norms, and Perceived Behavioral Control as mediators. This quantitative study used an explanatory technique and a representative sample of 221 students from the University of Indonesia Maulana Malik Ibrahim Malang Faculty of Economics. This study used purposive and proportional sampling. This study uses Google Forms to collect primary data and give surveys. The Likert scale (1–5) measures participants' answers. SEM-PLS analysis is used to assess 55 items across six variables in this study. The analysis uses SmartPLS 3.0. This study shows that Generation Z's interest in Islamic Capital Market is not largely driven by religion or financial knowledge in Islam. The Theory of Planned Behavior (TPB) variables may affect Generation Z's intention in sharia investing. This study shows an indirect association between Islamic Financial Literacy and Religiousness and Generation Z's intention in Sharia investments.
FRET-FISH probes chromatin compaction at individual genomic loci in single cells
Authors: Mota Ana , Berezicki Szymon , Wernersson Erik , Harbers Luuk , Li-Wang Xiaoze , Gradin Katarina , Peuckert Christiane , Crosetto Nicola , Bienko Magda
Published: May 2024

Chromatin compaction is a key biophysical property that influences multiple DNA transactions. Lack of chromatin accessibility is frequently used as proxy for chromatin compaction. However, we currently lack tools for directly probing chromatin compaction at individual genomic loci. To fill this gap, here we present FRET-FISH, a method combining fluorescence resonance energy transference (FRET) with DNA fluorescence in situ hybridization (FISH) to probe chromatin compaction at select loci in single cells. We first validate FRET-FISH by comparing it with ATAC-seq, demonstrating that local compaction and accessibility are strongly correlated. FRET-FISH also detects expected differences in compaction upon treatment with drugs perturbing global chromatin condensation. We then leverage FRET-FISH to study local chromatin compaction on the active and inactive X chromosome, along the nuclear radius, in different cell-cycle phases, and during increasing passage number. FRET-FISH is a robust tool for probing local chromatin compaction in single cells.
Deciphering the Ages of Saline Water in the Baltic Sea by Anthropogenic Radiotracers
Authors: Qiao Jixin , Lin Mu , Hou Xiaolin , She Jun , Murawski Jens
Published: May 2024

The slow water renewal endows the Baltic Sea a strong retention of pollutants/nutrients. Constraining water age is a practical way to depict the transport pathways/timescales for water masses and accompanying soluble substances. Although the water ages in the Baltic Sea have been resolved by 3D ocean models 20 years ago, the simulated results have not been verified. In this work, we exploited two anthropogenic radionuclides (129I and 236U) as an age marker to constrain the ages of inflowing North Sea saline waters into the Baltic Sea. Our results indicate that the Baltic Sea has a highly stratified structure with distinctly different timescales for surface-water and deep-water circulations (3 ± 2 and 20 ± 3 years, respectively), providing the first observation-based proof for the multi-decadal retention of (radioactive) pollutants within the Baltic Sea. This work demonstrates the power of anthropogenic radiotracers in investigating hydrodynamic processes in the Northwestern European coastal areas.
Predicting the Rate of Inflation in Uzbekistan using seasonal ARIMA models
Authors: Ray Indrajit Sinha , Kler Rajneesh , Priyanshu Deepa , Mouqdadi Mahera , Arora Manik , Ather Danish
Published: May 2024

Adopting the univariate time series modeling, particularly the ARIMA and seasonal ARIMA models, the current study attempts to forecast the rate of inflation for the Uzbek economy. The current macroeconomic monetary policy regime in case of Uzbekistan is to contain the rate of inflation and the economic policies and reforms of the country are also targeting to bring the medium-term inflation to about 5% in near future. Utilizing the data on month-on-month inflation and year on year inflation published by the Central Bank of Uzbekistan the study tries to fit an appropriate model looking at the seasonal fluctuations and cyclical trends as embedded in the inflation data. An in-depth econometric analysis is carried out using the univariate time series modeling and appropriate statistical test such as augmented Dickey fuller test for unit root the auto correlogram function and the partial auto correlogram function. As per the results of the test an appropriate autoregressive integrated moving average model is fitted of the relevant order to forecast the month on month and year on year inflation rate for next five months commencing October 2023. The predicted values of the rate of inflations are also tested against the actual realized values and the result of the study shows that the predicted values are approximate to the actual realized inflation rates. This leads to strong policy directions which will be helpful for the monetary authorities to direct the policy towards achieving the objective of targeted inflation rate for the Uzbek economy.
Immediate Loading of Implants Placed in Fresh Extraction Sockets in the Posterior Region. A Systematic Review
Authors: Sadykov Alexander , Romanenko Natalia , Mirosh Danil , Polyakova Tatyana
Published: May 2024

Purpose: To determine the essential torque, length and diameter of implant inserted into fresh extraction socket in posterior region in order to load it immediately. To find out the preferred bone type and peri-implant changes after loading.
Materials and methods: This study is based on searching scientific research papers using the following databases: MEDLINE - PubMed, Google Schoolar, Scopus, Cochrane, Web of Science. No filters and limits were used. Indexed databases were searched from 1990 up to 2023 using the following terms in different combinations: “immediate loading of implants”, “in the posterior”, “immediate implant placement/insertion”, “immediate provisionalization”, “fresh extraction sockets”, “bone density”, “torque”, “primary stability”, “peri-implant tissues”. The selection process started by carefully reading the title, followed by the abstract, the objectives and the full body of each article and paper. Articles identified as being potentially relevant based on their titles were evaluated by a reading of their full text, including reference to objectives, methods/approaches, and participants/populations and results. Studies that are not eligible based on the examination of the full text were excluded. Two articles were of the animal studies. The rest of 8 studies were the controlled clinical trials.
Results: A total of 201 studies were searched on indexed databases. However, only 10 of the papers met the inclusion criteria. Four groups of authors indicate the use of conical implants. Regardless of placement location, the most commonly used wide implant is greater than 3.5 mm. Meanwhile all authors followed the standard surgical protocal and placed the implants with an insertion torque ≥35 Ncm except for Degidi et al. (2006) who used ≥25 Ncm.
There is no significant difference among survival rate of immediate and delayed placed implants.
Evaluation of bone density was made according to the criteria by Lekholm and Zarb (1985) and Misch, Judy (1987).
Conclusion: The current systematic review shows that immediate loading of implants inserted in fresh extraction sockets in the posterior demonstrates good treatment outcome with regard to implant survival and marginal bone loss.
Biochemical and histological changes in sesame roots associated with charcoal rot disease resistance and enhancing plant growth induced by gamma-irradiated seeds at low doses
Authors: Ahmed Hoda A. M. , Moharam Moustafa H.A. , Mahdy Ahmed Y.
Published: May 2024

The current study aimed at irradiating sesame seeds with gamma radiation at 4.22, 8.45, 12.68, and 16.9 Gy and 2 and 4 cm to control charcoal rot disease caused by Macrophomina phaseolina (Mp) and also investigating their effects on some biochemical and histological changes in sesame roots associated with charcoal rot disease resistance with enhancing plant growth, seed yield, and oil content. In pot and field experiments under either artificial or natural soil infestation with the Mp inoculum, sowing of irradiated sesame seeds with gamma radiation at low doses significantly reduced the incidence of charcoal rot disease recorded based on root colonization by the Mp fungus and developed symptoms and enhanced plant growth measured by increasing plant height, number of capsules, and seed yield per plant, as well as percent of seed oil content compared with the control of non-irradiated seeds. The irradiation dose of 12.68 Gy was the most effective, followed by the 8.45 Gy dose. The biochemical study of sesame roots associated with charcoal rot disease resistance induced by gamma-irradiating seeds at 12.68 Gy at 2 cm showed a gradual increase in the total protein content, the activity of peroxidase and polyphenol oxidase, phenolic, and lignin contents in plant roots for up to 28 days compared to those originated from non-irradiated seeds. The histological study of the protected plant roots at 28 days old originating from seeds exposed to a 12.68 Gy dose showed a high thickening of the cuticle and epidermis cell walls and lignified cortical cells.
Diettary Approach to Stop Hypertension Adherence and Associated Factor Among Individuals With Hypertension in West Gojjam Zone Public Hospitals, North West Ethiopia, 2023:mixed approach
Authors: Asmare Melaku , Mengistu Berhanu , Desalegn Nigatu , Derso Terefe
Published: May 2024

Background; - Hypertension is a major public health concern with a higher contribution to world morbidity and mortality. DASH diet adherence is key to maintain blood pressure levels and prevent its complications but in Ethiopia, there is a limited evidence about its adherence. This research explores the DASH diet adherence and fill knowledge gaps. Objective;-The aim of this study was to identify DASH diet adherence and associated factors and explore barriers and contributing factors among individuals with hypertension in West Gojjam Zone public hospitals, Northwest Ethiopia, 2023.
Method; - A cross-sectional study supplemented with a qualitative approach was used among 582 participants. A systematic random sampling and purposeful sampling technique were used for participant selection. Epi Info version 7.5 for data entry and STATA 17 for analysis were used. Open Code 4.2 was used for thematic analysis of qualitative data. In bivariable analysis, a p value of 0.2 was entered into multivariable analysis. Crude odd ratio (COR) and then an adjusted odds ratio (AOR) at 95% CI was also used to measure the strength, and the significance of the variable was declared at a p value of ≤0.05.
Result; - The overall proportion of good DASH diet adherence of the study was 40.7% [CI; 36.65, 44.7]). A multivariable logistic regression showed that who had good knowledge about hypertension (AOR=2.54, CI: [1.66-3.88]), Strong social support(AOR=3.4, CI: [1.12, 4.4]), presence of co- comorbidity( AOR=2, CI;[1.71, 4.52]), presence of family history (AOR1=3, CI; [1.37, 7.0]) and diagnosis duration of HTN >10 years(AOR;3.3 CI;[1.1, 9.8]) and 5-10 years(AOR=2.38, CI;[1.23, 4.55]) were significantly associated with good DASH diet adherence. Economic problem, lack of family support, working condition, inaccessibility of the diet and social life were also a barrier for good adherence.
Conclusion; this study has revealed that only two-fifths of respondents had with good DASH diet adherence. Good knowledge for hypertension, presence of family history, presence of comorbidity, strong social support, and long duration of hypertension diagnosis were significantly associated with DASH diet adherence. Financial problems, the inaccessibility of diet, working condition, social life interactions, and the absence of family support were barriers to good adherence. Nutritional education, increasing production of fruit and vegetables are recommended.