bluuebunny/crossref_metadata_2025 huggingface dataset:
Extraction And Characterization of Bioactive Peptides Derived from the Hydrolysates of Total Soluble Proteins of Pistachio Nuts (Pistacia vera L.)
Authors: Dumandan Nico G. , Angelica Mark Rickard N. , Belina-Aldemita Ma. Desiree , Torio Mary Ann O.
Published: March 2018

This study explored the potential of pistachio nut (Pistacia vera L.) total soluble proteins to release bioactive peptides exhibiting angiotensin-converting enzyme (ACE) inhibition, antioxidative, and antibacterial activities. The total soluble proteins were extracted from the ground, defatted nut using 0.010 M phosphate buffered saline, pH 6.8. The extracted proteins were hydrolyzed at different time intervals using trypsin and chymotrypsin. Hydrolysates of the total soluble proteins at 24 h digestion time exhibited the highest ACE-inhibition activity of 76.67 ± 0.10% and 70.83 ± 0.00% for chymotrypsin and trypsin digestion, respectively. The 24 h enzymatic hydrolysates were further fractionated in RP-HPLC using a C18 Vydac column. The C1 fraction from the 24 h chymotryptic hydrolysates and T2 from the 24 h tryptic hydrolysates exhibited the highest ACE-inhibition activities with an IC50 value of 147.7 ± 0.8 and 148.7 ± 0.6 μg/mL, respectively. The 24 h chymotryptic and tryptic hydrolysates also exhibited a DPPH radical scavenging activity of 83.7 ± 1.1% (EC50 = 356.5 ± 1.0 μg/mL) and 80.4 ± 0.2% (EC50 = 402.7 ± 1.1 μg/mL), respectively. The hydroxyl radical scavenging activities of the 24 h chymotryptic and tryptic hydrolysates were found to be 22.8 ± 1.0 and 16.6 ± 3.7%, respectively. However, the 24 h tryptic and chymotryptic hydrolysates did not exhibit any antibacterial activity against the gram-negative Escherichia coli and gram-positive Staphylococcus aureus. Therefore, the total soluble proteins of pistachio nuts were found to contain peptides exhibiting ACE-inhibition and antioxidative activities upon hydrolysis with trypsin and chymotrypsin.
Simple and Efficient Method for the Synthesis of Galactofuranosides
Authors: Completo Gladys C. , Sangalang Reymart V. , Pique Beatrice M. I. , Nacario Ruel C.
Published: March 2018

An efficient and improved one-pot method for the synthesis of galactofuranosides via iodine-promoted cyclization of galactose diethyl dithioacetal in the presence of alcohol, acting both as solvent and nucleophile, is described. The reaction is carried out at room temperature. Alcohols, such as methanol, cyclohexanol and tert-butanol, were used as nucleophiles for the reaction using 2%, 3% and 5% iodine promoter, respectively. A key finding in this study was that the iodine-promoted cyclization of galactose diethyl dithioacetal with alcohol led to selective formation of β-galactofuranoside allowing the efficient preparation of derivatives of this monosaccharide.
Breastmilk Metabolomics: Bridging the Gap between Maternal Nutrition and Infant Health Outcomes
Authors: Sumayao Rodolfo Jr. , Benigno Sol Joaquin , Jaen Gerald Anthony , Martin Marilen , Sagayap Charmaine
Published: March 2018

Breastmilk (BM) is a primary source of nutrition for the newborn infant and its first six months of life. Although the importance of BM in the proper growth and development of infants have previously been recognized in various research studies, it was not until various metabolites were probed in BM that researchers realized the various beneficial effects of BM beyond its nutritive value. Metabolomics has emerged as a robust methodology to comprehensively profile various metabolites in food and biological fluids. Although still in its incipient stages, BM metabolomics has provided invaluable insights into the chemical interaction between mother and infant. NMR- and MS-based techniques have made it possible to explore the metabolome of BM and link it to various aspects of maternal phenotype and nutrition and breastfed infant health outcomes. In addition, recent developments in analytical approaches for BM metabolite analysis and metabolomic data analysis have allowed researchers to increase the coverage of detected metabolites using multiple platforms and support its functional characterization which aids in investigation of the clinical and biological importance of metabolites. These advancements can potentially aid in the development of strategies to promote healthy feeding practices for infants or novel therapeutic and nutrition advances in pediatric research.
Preliminary Results Of Archaeological Investigation In Cagsawa Ruins In Albay, Philippines: Sacred Spaces Archaeology
Authors: Recto Angel Sarmiento , Recto Evangelina Ramos , Avellana Reynaldo Ramos
Published: March 2018

The Cagsawa Ruins is a popular name of the former Franciscan missionary complex which was demolished and rebuilt – particularly the church and convent – in 1724 by Fray Francisco Blanco, OFM, to make it bigger and stronger. The place was devastated by a violent volcanic eruption on 1 February 1814, when thousands of people in the nearby towns of Camalig, Daraga and Budiao were killed by pyroclastic flows and lahar. Since the 1814 eruption of Mount Mayon, the Cagsawa Ruins have been left undisturbed. No archaeological activities had been made in the area. The entire plan and blueprint of the Franciscan missionary complex remained unknown to many after the devastating eruption of Mayon. Some parts of the stone structures are still visible, while others are submerged. This paper will share the preliminary results of archaeological investigation at the Cagsawa Ruins.
La aspiración de crecimiento del crecimiento del emprendedor: el papel del contexto desde una perspectiva internacional
Authors: Ruiz Arroyo Matilde , Fuentes Fuentes María del Mar , Ruiz Jiménez Jenny María
Published: March 2018

Las aspiraciones del emprendedor con respecto al futuro de su empresa pueden concebirse como antecedente de su potencial contribución económica, en términos de crecimiento en el empleo. En este trabajo presentamos un modelo explicativo de la alta aspiración de crecimiento del emprendedor, sobre el cual evaluamos la influencia del contexto en las relaciones propuestas. En base a datos provenientes del Proyecto Global En-trepreneurship Monitor (GEM) a nivel internacional y en su edición de 2009, planteamos un estudio empírico sobre una muestra de 8.641 emprendedores de 49 países, propietarios y gestores de empresas nuevas y jóvenes. Aplicando un enfoque comparativo, nuestros resultados sugieren que el contexto actúa como condicionante de orden superior que afecta a la influencia que ejercen las variables y características individuales propuestas sobre la probabilidad de que el emprendedor desarrolle altas aspiraciones de crecimiento. En conclusión, la aspiración de crecimiento no depende sólo de estímulos y límites individuales, sino de condicionantes del entorno que moderan su formación de expectativas y aspiraciones emprendedoras. Confirmamos así la importancia de las condiciones contextuales en la con-figuración del comportamiento emprendedor.
Вариационный метод решения общей задачи о колебательно-вращательных состояниях молекул
Authors: Грибов Л.А.
Published: March 2018

Предложен метод расчета уровней энергии и волновых функций для колебательно-вращательных состояний молекул, не требующий выделения видов движения. Указано, каким образом может быть сформирована соответствующая энергетическая матрица, диагонализация которой и приводит к нужному решению. Простота вычислений элементов этой матрицы обеспечивает возможность анализа очень крупных молекул.
Electronic structure and relative stabilities of 10- and 12-vertex. Closo and nido-heteroborane clusters of Ga, Ge and As elements
Authors: Ababsa S. , Zouchoune B.
Published: March 2018

A DFT method with the B3LYP functional and the 6-311++G(d,p) diffuse basis set is used to predict geometries, relative stabilities, electronic structures, and the bonding of closo- and nido- GamBn–mHn2–, GemBn–mHnm–2, and AsmBn–mH n2m–2 (n = 10, 12 and m = 1, 2) Clusters are obtained by replacing BH with isolobal GaH, GeH+, and AsH2+ fragments, keeping the same skeleton electron pairs (SEP). Based on the polyhedral skeletal electron pairs theory (PSEPT), closo and nido structures are predicted and can be of significant interest for experimentalists working in the field of heteroboranes. Different cluster stabilities are studied according to Gimarc’s and Williams’ rules, where our calculations show that the monosubstituted clusters deviate from these rules, giving rise to open structures. As2B8H n2+ as 10-vertex structures lead to nido-type clusters, however, GemBn–mH nm–2 (n = 10, 12 and m = 1, 2) give rise to closo isomers with close energies. All optimized structures exhibit large HOMO—LUMO gaps suggesting a good kinetic stability, thus predicting their isolation and characterization.
Высокотемпературные дифракционные исследования процесса расслоения марганец-галлиевой шпинели состава Mn1.5Ga1.5O4
Authors: Венедиктова О.С. , Булавченко О.А. , Цырульников П.Г. , Афонасенко Т.Н. , Винокуров З.С. , Цыбуля С.В.
Published: March 2018

Стабильность смешанного оксида Mn1.5Ga1.5O4 со структурой шпинели, полученного в инертной среде (1000 °C, Ar), исследовали на воздухе в широком температурном интервале 30—1000 °C с использованием термогравиметрии и высокотемпературной рентгеновской дифракции. При нагреве наблюдаются обратимые процессы расслоения исходной шпинели. От 30 до 600 °C в поверхностный слой исходной шпинели Mn1.5Ga1.5O4 присоединяется кислород, благодаря чему образуется новая фаза, отличающаяся от "родительского" оксида стехиометрией по кислороду (формируются катионные вакансии). Продукт расслоения представляет собой два оксида Mn1.5Ga1.5O4 и Mn1.5–xGa1.5–x[·]xO4. Выше 600 °C, наоборот, происходит потеря кислорода, уменьшается концентрация катионных вакансий в Mn1.5–xGa1.5–x[·]xO4 и идет обратный процесс кристаллизации однофазного оксида. При 1000 °C вновь образуется одна фаза шпинели, близкая по составу к исходной "родительской" фазе Mn1.5Ga1.5O4. При охлаждении вновь наблюдается расслоение этой фазы вследствие присоединения кислорода.
New Co(II) and Mn(II) complexes with 4'-substituted 2,2':6',2''-terpyridine ligands
Authors: Fu W.-W. , Shu X. , Luo Y.-L.
Published: March 2018

Three Co(II) complexes [Co(meophtpy)2](ClO4)2×2CH3CN (1), [Co(nh2phtpy)2](ClO4)2·2CH3CN (2), [Co(ftpy)2](ClO4)2·2CH3CN (3) and three Mn(II) complexes [Mn(nme2phtpy)2]·(ClO4)2·2CH3CN (4), [Mn(ftpy)2](ClO4)2·CH3CN (5), [Mn(meophtpy)(H2O)(NO3)2]·CH3CN (6) (meophtpy, 4'-(4-methoxyphenyl)-2,2':6',2''-terpyridine; nh2phtpy, 4'-(4-aminophenyl)-2,2':6',2''-terpyridine; ftpy, 4'-(furan-2-yl)-2,2':6',2''-terpyridine; nme2phtpy, 4'-(4-(N,N-di­methylamino)phenyl)-2,2':6',2''-terpyridine) are synthesized and their structures are determined by single crystal X-ray diffraction. Crystal data for 1 are: monoclinic, space group C2/c, a = 14.4781(5), b = 16.2221(7), c = 21.3617(9) Å, and Z = 4. For 2: monoclinic, space group C2/c, a = 14.554(6), b = 15.239(6), c = 21.754(9) Å, and Z = 4. For 3: monoclinic, space group C2/c, a = 14.5285(16), b = 15.3234(16), c = 21.154(2) Å, and Z = 4. For 4: triclinic, space group P-1, a = 12.132(5), b = 12.536(5), c =17.840(10) Å, and Z = 2. For 5: triclinic, space group P-1, a = 9.993(10), b = 13.950(13), c = 15.511(15) Å, and Z = 2. For 6: monoclinic, space group Pc, a = 12.402(7), b = 12.919(8), c = 7.893(5) Å, and Z = 2. In complexes 1—5, Co(II) or Mn(II) ions are coordinated by six N atoms from two terpyridine moieties. In complex 6 the Mn(II) atom coordinates only one terpyridine ligand. All these complexes are linked by hydrogen bonds and face-to-face π—π interactions into three-dimensional networks. In complexes 4—6 the available solvent areas imply their potential applications in gas adsorption or catalysis.
Dimorphism of hexaaquanickel(II) bis(p-nitrobenzoate) dihydrate salt: A new triclinic crystal form
Authors: Ibragimov A.B. , Englert U. , Ashurov J.M. , Wang A.
Published: March 2018

Room temperature crystallization from a water/ethanol solution of NiSO4, p-nitrobenzoic acid (HPNBA), and thiourea yields single crystals of [Ni(H2O)6](PNBA)2·2H2O. Crystal data are: a = 5.9626(8), b = 7.3552(11), c = 12.3459(17) Å, α = 97.885(12), β = 96.714(11), γ = 91.158(11)°, V = 532.28(13) Å3, space group P1̅, Z = 1. An alternative monoclinic crystal form of the same compound with a slightly lower packing efficiency was previously obtained. The Ni(II) cation is located on a crystallographic inversion center and octahedrally coordinated by six water molecules. The PNBA moieties occupy an outer coordination sphere acting as counter-anions. An intricate system of H bonds between the complex cation, the PNBA anions, and the co-crystallized water molecules results in a three-dimensional network.
Особенности молекулярного строения нового комплекса 3-(бензо[d]оксазол-2-ил)-1-(2-(1,3,3-триметилиндолин- 2-илиден)этилиден) нафталин-2(1H)-она хлорида цинка
Authors: Ткачев В.В. , Утенышев А.Н. , Чернышев А.В. , Ковальчукова О.В.
Published: March 2018

Проведено рентгеноструктурное исследование нового 3-(бензо[d]оксазол-2-ил)-1-(2-(1,3,3-триметилиндолин-2-илиден)этилиден)нафталин-2(1H)-она хлорида цинка 1. Показано, что в комплексе 1 молекула лиганда имеет транс—транс—цис-конформацию, в которой индолиновый атом азота ориентирован в одну сторону с хелатным циклом, что может способствовать дополнительной координации с комплексообразующим атомом.
Строение цепочечного координационного полимера {[Nd(phen)2(H2O)Nd(phen)(H2O)3 (μ-OH)2][Re4S4(CN)12]}·phen·3,5H2O
Authors: Литвинова Ю.М. , Куратьева Н.В. , Гайфулин Я.М. , Миронов Ю.В.
Published: March 2018

Методом гидротермального синтеза был получен новый цепочечный полимер на основе кластерных анионов [Re4S4(CN)12]4– и катионов Nd3+. Структура соединения {[Nd(phen)2(H2O)Nd(phen)(H2O)3(μ-OH)2][Re4S4(CN)12]}·0,5phen·3,5H2O (1) была определена методом РСА. Соединение кристаллизуется в пространственной группе P1̅ с параметрами ячейки a = 12.8818(5), b = 14.1219(5), c = 22.0347(9) Å, α = 98.168(2), β = 93.518(2), γ = 95.734(2)°, V = 3936.3(3) Å3.
Кристаллическая структура двух β-дикетонатов самария и их свойства
Authors: Уркасым кызы С. , Шэнь Хуан , Мосягина С.А. , Корольков И.В. , Первухина Н.В. , Крисюк В.В. , Стабников П.А.
Published: March 2018

Получены трис-дипивалоилметанат самария(III) [Sm(dpm)3]2 (I) и тетракис-гексафтор­ацетилацетонат самария(III) натрия {Na[Sm(hfa)4]}n (II). Определены кристаллические структуры I при 150(2) K (пр. гр. P21/n, a = 12,279(1), b = 27,726(3), с = 21,884(2) Å, β = 105,317(3)°, V = 7186,0(11) Å3, Z = 4) и II при 150(2) K (пр. гр. C2/c, a = 21,693(2), b = 12,2068(7), с = 14,402(1) Å, β = 124,731(3)°, V = 3134,2(4) Å3, Z = 4) Структура комплекса I близка к известным ранее димерным комплексам [Ln(dpm)3]2 (Ln = La, Pr, Nd, Eu, Gd, Tb), а структура комплекса II — к известным комплексам {Na[Ln(hfa)4]}n (Ln = Y, Eu, Er). Методом термогравиметрии показано, что летучесть трис-дипивалоил­метанатов РЗЭ возрастает от Lu к La, а тетракис-гексафторацетилацетонатов натрия РЗЭ — от La к Lu.
Новый подход к анализу молекулярных упаковок в кристаллах с использованием атом-атомных потенциалов
Authors: Малеев А.В. , Геворгян А.А. , Потехин К.А.
Published: March 2018

Предложен новый подход к исследованию и описанию молекулярных упаковок в кристаллах с использованием метода атом-атомных потенциалов. Подход применяется к задаче выявления устойчивых межмолекулярных контактов и молекулярных агломератов для двух кристаллических структур, исследованных ранее РСА.
Кристаллическая структура координационных полимеров, полученных на основе гетерометаллического карбоксилатного комплекса
Authors: Сапьяник А.А. , Семененко Е.Э. , Самсоненко Д.Г. , Дыбцев Д.Н. , Федин В.П.
Published: March 2018

При взаимодействии гетерометаллического карбоксилатного комплекса состава [Li2Zn2(piv)6(py)2] с изофталевой кислотой (H2ibdc), тримезиновой кислотой (H3btc) и в присутствии как 4,4'-бифенилдикарбоновой кислоты (H2bpdc), так и 4,4'-биспири­дилпропана (bpp) получены три новых металл-органических координационных полимера [Zn(Hibdc)2]·DMF (1), (H2NMe2)[Li2Zn3(H2O)(dmf)(Hbtc)3(btc)]·6DMF·H2O (2) и [Li2Zn2(H2O)2(bpp)(bpdc)3]·7DMF (3). Структура полученных соединений установлена методом рентгеноструктурного анализа монокристаллов. В изучаемых реакциях структура исходного фрагмента {Li2Zn2} не сохраняется. Происходит сложная фрагментация этого четырехъядерного блока, в том числе с образованием биядерных гетерометаллических димеров {LiZn}.
Características del hábitat de sitios de descanso del búho manchado (Strix occidentalis lucida) en la Sierra Madre Occidental, México
Authors: Silva-Piña Mariana Jovita , Tarango-Arámbula Luis Antonio , Clemente-Sánchez Fernando , Cortez-Romero César , Velázquez-Martínez Alejandro , Rafael-Valdez Javier , Ugalde-Lezama Saúl
Published: March 2018

El búho manchado (Strix occidentalis lucida) es una especie amenazada y poco estudiada en México. En este estudio caracterizamos el hábitat de sus sitios de descanso (reproductivos y no reproductivos) y aleatorios (sitios en donde la especie se distribuye aleatoriamente sin un patrón) en Aguascalientes, Durango y Zacatecas e identificamos las variables físicas y biológicas (hábitat) que seleccionan. Usamos estadística descriptiva y determinamos mediante Regresión de Poisson (ARP) aquellas variables de hábitat que tuvieron un efecto sobre los búhos registrados; asimismo, agrupamos las variables identificadas por el ARP con un análisis de Correspondencia Simple (ACS) y realizamos una prueba de Kruskal-Wallis con el objeto de identificar posibles diferencias significativas entre sitios (descanso y aleatorios). Localizamos en total 29 búhos (parejas, polluelos e individuos solitarios) en 11 sitios de descanso en bosques de encino-pino (63.6%), en laderas con exposición norte y más inclinadas que la de los sitios aleatorios. Los sitios reproductivos estuvieron en una elevación más alta, comparada con los sitios no reproductivos y aleatorios; asimismo, en estos sitios encontramos una mayor densidad de árboles, con árboles usados como percha y árboles muertos (en pie) de dimensiones más grandes, comparados con los árboles encontrados en los sitios de descanso no reproductivos y alea­torios. Sin embargo, sólo la variable densidad de árboles fue diferente estadísticamente (P < 0.05) entre sitios. Las variables de vegetación que se asociaron más a los sitios de descanso del búho manchado fueron la altura del árbol de percha, la cobertura arbustiva y DAP del árbol de percha. Esta información la podemos utilizar en planes de manejo y conservación de la subespecie en México.
Swelling Soils in the Campo de Calatrava Volcanic Field, Spain: General View
Authors: Herrero-Debon Lorenzo , Hidalgo Signes Carlos , Torrijo F. J. , Cortés R.
Published: March 2018

Swelling soils are cohesive materials capable of experiencing large volume changes linked to variation of its moisture content. Campo de Calatrava is an area of Ciudad Real province, Spain, where this kind of soils can be found due to the weathering of volcanic deposits generated during the Neogene. They have been seldomly studied due to the lack of population in the area and the moderate swelling potential compared to more expansive materials that can be found in other zones of the Iberian Peninsula. This study presents a new dataset of laboratory testing results not previously published based on swelling pressure at constant volume on oedometer apparatus. This additional data obtained mostly from site investigations for building construction has been integrated with the available geotechnical data on the literature to provide valuable observations (but preliminary at this stage; additional research is forthcoming) about the expansivity of Campo de Calatrava soils and their index properties.
The Perception of Ageism, Generativity, and the Attainment of Developmental Tasks of Elderly Widowers and Widows in Bogor, West Java, Indonesia
Authors: Rahmaniah Bona Intan , Krisnatuti Diah
Published: March 2018

In every stage of human lives as well as later adulthood (elderly), there are developmental tasks to be attained and demand the elderly to adapt to various changes both from the internal and external environment. The aim of this research was to analyze the influence of ageism and generativity on the developmental task of elderly widower and widow. The cross-sectional study was used as the design of this research. The research was conducted in Empang Village, South Bogor Sub-District and West Cilendek Village, West Bogor Sub-District, Bogor City. As many as 60 persons were involved as research sample, consisted of 30 elderly widowers and 30 elderly widows which were chosen by snow-ball techniques. The result showed that there was no significant difference in developmental task of elderly widower and widow. The category of ageism was low while generativity and developmental task were moderate. There were significant positive correlations and influences of the length of education and generativity on developmental tasks of elderly widower and widow.

 
Economic Pressure, Livelihood Strategy, and Family Well-being in Cimanuk Watershed, Garut and Indramayu, West Java, Indonesia
Authors: Sabania Hamira , Hartoyo Hartoyo
Published: March 2018

The objective of this study is to analyze economic pressure, livelihood strategy, and well-being of families in Cimanuk Watershed. This study used a cross-sectional study design. As many as 72 samples of lower middle class families (determined by Poverty Line of BPS 2013) who have toddler and school age children were chosen puposively. This study was conducted in Garut District and Indramayu District. The results showed that inspite of being in poverty, only one out of three families felt highly economic pressure, and one out of ten families perceived poorly well-being. Family economic pressure was affected by the region difference, education level of father, and ownership of financial capital. Meanwhile, family well-being was affected by the education level of the father, financial capital, social capital, access to the environment, economic pressure, and livelihood diversification. Livelihood diversification is the strategy that most poor families did in Cimanuk Watershed. Livelihood diversification of families was affected by the age of the wife, expenditure per capita, social capital, and access to the environment.
The Effect of Family Function and Conflict on Family Subjective Well-being with Migrant Husband
Authors: Herawati Tin , Endah Nafi Yuliana
Published: March 2018

Poverty, limited employment opportunities, and low rate of labor wage cause couples undergo long distance married because the husband has to work far from the house. This gives impact to family subjective well-being so that the family need to role a family function in order to minimize conflicts. This research aimed to analyze the effect of family function and conflict on family subjective well-being with migrant husband. There were 60 samples in  this research which consisted of family with migrant husband teenager children (12-17 years old) in Banyuresmi village, Garut. The wife was the respondent of this research. The sampling technique used here was nonprobability sampling method with form purposive sampling. The data were collected by interviewing the respondents using a questionnaire. The results showed that most of the samples were categorized into families which had good family function, moderate family conflict, and moderate family subjective well-being. Family function affect  significantly positive to family subjective well-being. Parental-teenagers conflict affect significantly negative to family subjective well-being.
Child Vulnerability and Well-being among Farmer Families
Authors: Primasari Danisya , Puspitawati Herien
Published: March 2018

This research aimed to identify vulnerability and well-being of children in a family of farmers, identify the typology of vulnerability and well-being of children in the family of farmers, and analyze the relationship between family characteristics, characteristics of children with the vulnerability and well-being of children. The population in this research is family farmers who have children of 4 and 5th grade who reside in the village Sindangjaya, District Cipanas, Cianjur with a sample of 35 children. Sampling was conducted using probability sampling method with random sampling techniques. The results showed that the internal susceptibility to family farmers is low, relatively low external vulnerability, and low well-being. Typology vulnerability of children and the well-being of children in a family of farmers included in Type 1 and Type 4. There was a significant negative correlation between family size and order of the child with the child's welfare, but there was no significant relationship between the characteristics of families and children with children's vulnerability.
THE INFLUENCE OF SOCIAL SUPPORT AND FINANCIAL MANAGEMENT TOWARD FAMILY WELL-BEING IN EARLY MARRIAGE
Authors: Yulfa Rahmi , Herawati Tin
Published: March 2018

Aim of this study is to examine the influence of social support and financial management toward family well-being in early marriage. Research was located in Cibeber II village and Karehkel village, Leuwiliang sub-district, Bogor district, West Java. Samples of this study are 60 women from an early marriage family (under 20 years old) whose children are under five years old, and willingly participate in this study. Samples were chosen purposively. Social support were positively significant correlation with financial management, objective well-being and subjective well-being. The factors that affect objective family well-being are per capita income and financial management. On the subjective family well-being, the factor of affect is per capita income and emotional social support
METODOLOGIA E PESQUISA NA PÓS-GRADUAÇÃO: a experiência do Mestrado Profissional em Políticas Públicas, Gestão e Avaliação da Educação Superior – MPPGAV/UFPB
Authors: De Sousa Junior Luiz , Farias Maria da Salete Barboza de
Published: March 2018

Este artigo objetiva contribuir para o debate sobre a questão metodológica e da pesquisa no campo dos Mestrados Profissionais em Educação. Nele, procura-se explicitar as bases epistemológicas que vem guiando os procedimentos técnico-operacionais na gestação dos trabalhos finais, bem como os dilemas e desafios dessa modalidade de pós-graduação.
Aplikasi Monitoring Proses Distribusi Makanan Beku Untuk Informasi Secara Realtime
Authors: Susliansyah Susliansyah , Handayanna Frisma
Published: March 2018

The control of frozen food distribution process done by the logistic part in obtaining the data is still manual, using the form and excel, causing the admin difficulty in monitoring and controlling the distribution process or the delivery of frozen food to store or outlet. Problem solving is made an application using data collection method and RAD method, where the model of Rapid Application Development (RAD) has business modeling stage using kebutuah application admin and user, data modeling that explains the use of ERD and LRS from the database side, about usecase diagrams and activity diagrams from the application process side, application generation evolves about programming languages in application creation while testing and turnover describes the use of white box testing. The purpose of the application is made to facilitate the related division in processing the data distribution process, monitor and control the distribution process and obtain information distribution process in realtime.
KAYNAĞA GİTMEK: GİRESUN YÖRESİNDE UNUTULMUŞ BİR DEYİMİN TARİHSEL ARKA PLANI
Authors: KAYA Mevlüt
Published: March 2018

Özet:
Türk
boylarının geçmişteki bozkır yaşantısı, tarihsel süreçte tedricen değişiklikler
göstererek yirminci yüzyıla dek varlığını sürdürmüştür. Eski yurtları olan Orta
Asya’daki göçebe yaşam tarzını Anadolu’da da yüzyıllarca sürdüren Türkler,
yaylacılığa endeksli hayvancılıkla uğraşmaktayken, ilerleyen zamanlarda tarımsal
faaliyetlere de zaman ayırmaya başlamışlardır. Tarımsal faaliyetlerin gündelik
yaşamda önem kazanmaya başlamasıyla, Türklerin yaylacılık geleneğinde işbölümü
ve zamanlamaya dair değişiklikler gerçekleşmiştir. Ziraat ve yaylacılığın bir
arada yürütülmesi için, aile fertleri arasındaki rol dağılımı git gide belirgin
bir hâl almıştır. Osmanlı’nın son dönemlerine gelindiğinde, yaylacılık faktörünün
bozkırdaki Türk toplumu üzerinde yeni kültürel sonuçlar doğurduğu görülmektedir.
Bu sonuçlara açık bir örnek niteliği taşıyan Giresun yöresindeki otçu göçü;
yaylacılık, hayvancılık ve ziraat işlerini birlikte yürüten ailelerde yeni kültürel
kavramları beraberinde getirmiştir: “Kaynağa gitmek”. Giresun yöresinde
yüzyıllarca kullanılmış olan bu deyim, otçu göçü geleneğinin önemini yitirmesine
paralel olarak unutulmaya yüz tutmuştur. Deyimin temelinde yatan
yaylacılık-hayvancılık-ziraat üçlemesinden doğan aile fertlerinin iş bölümü ve
ara zamanlara bağlı rol dağılımının daha iyi anlaşılması için Türk kültüründe
şenliklerin, göç ve göçebeliğin tarihsel arka planının incelenmesi
gerekmektedir. Bu doğrultuda çalışmada, Giresun yöresinde kullanılmış olan
“kaynağa gitmek” deyiminin tarihsel arka planı üzerinde durulacaktır.
BLACK MIRROR DİZİSİ THE NATIONAL ANTHEM BÖLÜMÜ'NÜN GÜNDEM BELİRLEME KURAMI ÜZERİNDEN İNCELENMESİ
Authors: Sayar Tahsin Eren
Published: March 2018

Siyasal güçlerin etkilerini toplumlar üzerinde
göstermeleriyle birlikte enformasyon araçlarının gündem belirleme ve halkı
etkileme noktasında kullanılması sıklaşmaya başlamıştır. Birçok siyasi güç,
özellikle basın mecraları ve sosyal medyayı kullanarak hem kitleleri etkileri
altına almayı amaçlamışlar hem de fikirlerinin toplum tarafından uygulanabilir
olması için çaba sarf etmişlerdir. Bu bağlamda medya araçlarının kullanılması
çeşitli dizi ve sinema filmlerinde de açıkça ele alınmıştır. İngiliz yapımı Black
Mirror dizisi de özellikle 1. Bölümü olan National Anthem'de bu konuya
değinmiştir. Çalışma kapsamında İçerik Analizi Metodu kullanılarak İngiltere
Başbakanı'ndan istenilen taleplerin sosyal medya ve televizyon kanalları
aracılığıyla yayınlanması sonucunda kitleler üzerinde ne şekilde etkiler
yarattığı ve gündem belirleme kuramının buradaki etkisi irdelenmiştir. Çalışma
sonucunda sosyal medya ve televizyonların gündem belirlemede son derece etkin
olduğu,bununla birlikte her iki mecranın da kendisine has bir takım
değişikliklere sahip olduğu sonucuna varılmıştır.
Синтез и цереброваскулярная противоишемическая активность новых производных 5-гидроксиадамантан-2-она
Authors: Курза Елена Владимировна , Авдюнина Н. И. , Ганьшина Тамара Сергеевна , Масленников Д. В. , Турилова А. И. , Пятин Б. М. , Грушевская Л. Н. , Зайцева Н. М. , Большакова Р. Ф. , Ковалёв Г. И. , Васильева Е. В. , Мирзоян Рубен Симонович
Published: March 2018

Проведен синтез и фармакологическое изучение новых производных 5-гидроксиадамантан-2-она с гетероароматическими, ароматическими и алифатическими кислотами (никотиновой, янтарной, пара-хлорфеноксиуксусной, 3,4,5-триметоксибензойной и анисовой) с целью поиска соединений, обладающих цереброваскулярной противоишемической активностью и не оказывающих гипотензивного действия. Наиболее выраженное влияние на мозговое кровообращение в условиях ишемии мозга оказывают эфиры янтарной кислоты 5-гидроксиадамантан-2-она (диэфир — Iа и моноэфир — Iб по 100 мг/кг внутривенно). Они не понижают уровень артериального давления, а моноэфир менее токсичен, LD50 740,0 (676,0 – 804,0) мг/кг. Анализ цереброваскулярного эффекта эфиров янтарной кислоты 5-гидроксиадамантан-2-она с помощью бикукуллина выявил участие ГАМК-ергического механизма сосудов мозга в его реализации. Однако методом радиолигандного анализа in vitro с использованием специфического лиганда [3H]-SR 95531 взаимодействие этих эфиров с ГАМКА-рецепторами мембран мозга крыс показано не было. Таким образом, моноэфир янтарной кислоты 5-гидроксиадамантан-2-она обладает выраженной цереброваскулярной противоишемической активностью и не оказывает гипотензивного эффекта. Последнее его выгодно отличает от используемых в неврологии препаратов (пикамилона, мексидола, нимодипина, циннаризина и кавинтона).
Разработка методики количественного определения ацетилсалициловой кислоты и ее основного метаболита методом ВЭЖХ с УФ-детектированием
Authors: Белов Вячеслав Юрьевич , Курсаков Сергей Васильевич , Севастьянов Виктор Иванович , Антонов Евгений Николаевич , Богородский Сергей Эдуардович , Попов Владимир Карпович
Published: March 2018

Разработана методика определения ацетилсалициловой кислоты и ее основного метаболита — салициловой кислоты в модельном растворе и плазме крови кроликов методом ВЭЖХ с УФ-детектированием. Пробоподготовку плазмы проводили методом высаливания. Хроматографический анализ осуществляли в изократическом режиме на колонке Hypersil BDS C18 с подвижной фазой ацетонитрил — вода (pH 2,5, 30:70) при длине волны 230 нм. Предел количественного определения ацетилсалициловой и салициловой кислот в модельном растворе составил 0,05 мкг/мл, в плазме крови — 0,2 мкг/мл. Разработанная методика применена для изучения новых форм ацетилсалициловой кислоты на основе биосовместимых полимерных носителей, в том числе для изучения фармакокинетики после внутримышечной имплантации.
Валидация методики подтверждения подлинности фармацевтической субстанции «Бусерелина ацетат» методом ЯМР спектроскопии
Authors: Кузьмина Наталия Евгеньевна , Моисеев Сергей Владимирович , Крылов Владислав Игоревич , Дерябин Александр Сергеевич , Яшкир Вадим Анатольевич , Меркулов Вадим Анатольевич
Published: March 2018

Оценена специфичность различных вариантов методики подтверждения подлинности фармацевтической субстанции «бусерелина ацетат» методом ЯМР спектроскопии путем сравнительного анализа спектров 1H и 13C бусерелина ацетата и [5-D-тирозин]бусерелина ацетата в различных растворителях. Найдено, что максимальное различие в спектральных данных диастереомеров наблюдается при использовании дейтерированной воды в качестве растворителя. Показано влияние растворителя и внутримолекулярных невалентных взаимодействий на обменные прототропные превращения в L-гистидиновом фрагменте анализируемых олигомеров. От скорости прототропной таутомерии зависит ширина сигналов данной аминокислоты в спектрах 13C. Рекомендовано использовать в фармакопейном анализе вариант методики, основанный на 13C ЯМР спектроскопии (растворитель — D2O).
APLIKASI AUTOMATISASI KILO WATT HERTZ PADA PEMAKAIAN DAYA LISTRIK DENGAN PC MENGGUNAKANDUAL TONE MULTIPLE FREQUENCY (DTMF)
Authors: Wincoko Wincoko
Published: March 2018

Membuat perangkat keras dan perangkat lunak yang berbasis mikrokontroler 89C51 denganPC menggunakan Dual Tone Multiple Frequency (DTMF). Melakukan pengukuran dayadengan menggunakan perangkat keras (hardware) dan perangkat lunak (software). Membuatrangkaian kwh meter digital yang dapat digunakan untuk pemakaian daya yang relatif besar.Mengimplementasikan sistem informasi pulsa daya listrik dengan PHP dan MYSQL dalampengembangan suatu aplikasi berbasis web.
PENERAPAN METODE PENEMUAN TERBIMBING UNTUK MENINGKATKAN HASIL BELAJAR SISWAKELAS XII IPA 4 SMAN 2 BANGKINANG KOTA PADA MATERI TRIGONOMETRI ANALITIKA
Authors: Ravikoh Ravikoh
Published: March 2018

Metode penemuan terbimbing dapat mencapai tingkat kemampuan yang lebih tinggi dan tahan lama membekas, karena siswadilibatkan dalam proses penemuannya. Beberapa penyebab rendahnya hasil belajar matematika siswa karena siswa tidak dilibatkan dalam proses penemuannya. Penelitian ini bertujuan untuk meningkatkan hasil belajar matematika siswa kelas XII IPA 4 SMAN 2 Bangkinang Kota Tahun Pelajaran 2016/2017 dengan menggunakan metode penemuan terbimbing. Bentuk penelitian ini adalah Penelitian Tindakan Kelas yang dilakukan dalam dua siklus. Hasil penelitian ini menunjukkan bahwa pada tes siklus I nilai rata-rata siswa sebesar 60,36 dengan ketuntasan sebesar 51,85%, pada tes siklus II nilai rata-rata siswa sebesar 68,89 dengan ketuntasan 74,07%. Terjadi peningkatan rata-rata hasil tes sebesar 8,53 dengan peningkatan ketuntasan sebesar 22,22%. Dapat diartikan bahwa penerapan metode penemuan terbimbing dapat meningkatkan hasil belajar matematika siswa.
PENERAPAN MODEL THINK PAIR SHARE UNTUK MENINGKATKAN KUALITAS PEMBELAJARAN OPERASI BILANGAN DENGAN BANTUAN MEDIA MANIPULATIF
Authors: Mashita Mashita
Published: March 2018

Tujuan penelitian ini adalah untuk meningkatkan kualitas pembelajaran operasi bilangan melalui model Think Pair Shareberbantuan media manipulatif pada siswa kelas II SDN 006 Sekip Hulu Rengat. Yang mana difokuskan untuk meningkatkan aktivitas siswa dalam pembelajaran operasi bilangan melalui model Think Pair Share berbantuan media manipulatif pada siswa kelas II SDN 006 Sekip Hulu Rengat, serta untuk meningkatkan hasil belajar (domain kognitif) siswa dalam pembelajaran pembelajaran operasi bilangan melalui model Think Pair Share berbantuan media manipulatif pada siswa kelas II SDN 006 Sekip Hulu Rengat. Desain yang ditetapkan dalam penelitian ini adalah penelitian tindakan kelas (PTK) di mana dalam pelaksanaan PTK terdapat empat tahapan yaitu perencanaan, pelaksanaan, observasi dan refleksi. Hasil penelitian yang didapatkan adalah aktivitas siswa dalam pembelajaran operasi bilangan dengan model Think Pair Sharemengalami peningkatan dengan skor akhir yaitu 15 yang artinya yaitu sangat baik. Sedangkan hasil belajar ranah kognitif hasil yang didapatkan yaitu memperoleh peningkatan dengan nilai rata-rata akhir 89,04 meningkat dari 83,04.
UPAYA MENINGKATKAN HASIL BELAJAR BAHASA INDONESIA ASPEK MENULIS DENGAN PENGGUNAAN MODELKOOPERATIF LEARNING TIPE STAD
Authors: Abdullah Nuraida
Published: March 2018

Penelitian ini difokuskan pada permasalahan kurangnya motivasi dan kurang tertarik untuk mengikuti pembelajaran khususnya aspek menulis. Hasil penelitian yang diperoleh yaitu persentase ketercapaian indicator hasil belajar mengalami peningkatan pada setiap siklus. Hasil belajar siswa kelas XI SMKN 1 Bangkinang sebelum menggunakan model Kooperatif Learning Tipe STAD masih berkategori kurang. Namun, setelah implementasi model pembelajaran Kooperatif Learning Tipe STAD  dalam dua siklus, rata-rata hasil belajar siswa meningkat. Hasil belajar siswa sudah melebihi batas KKM. Pada siklus 1 nilai yang diperoleh siswa kelas XI SMKN 1 Bangkinang dengan menggunakan model Kooperatif Learning Tipe STAD dengan jumlah siswa 31 orang, maka 22 orang siswa ( 70,97% ) telah tuntas sedangkan 9 orang (29,03%) masih belum tuntas dengan nilai rata – rata kelas yang diperoleh 70,35. Siswa yang mendapat nilai ≥ 7,5 atau sudah tuntas dalam pembelajaran bahasa Indonesia dengan model Kooperatif Learning Tipe STAD sebanyak 22 siswa (70,97%), sedangkan siswa yang mendapat ≤ 7,4 atau belum tuntas dalam belajar bahasa Indonesia dengan model Kooperatif Learning Tipe STAD sebanyak 9 siswa (29,03%) dari jumlah siswa sebayak 31 orang. Pada siklus 2 pada siklus 2 dapat dilihat hasil belajar siswa kelas XI SMKN 1 Bangkinang dengan menggunakan modelKooperatif Learning Tipe STAD . Nilai rata-rata  yang diperoleh siswa pada siklus 2 ini 77,25 dengan jumlah siswa 31 orang. Siswa yang mendapat nilai ≥ 7,5 atau sudah tuntas dalam pembelajaran bahasa Indonesia dengan model Kooperatif Learning Tipe STAD sebanyak 29 siswa (93,5%), sedangkan siswa yang mendapat ≤ 7,5 atau belum tuntas dalam belajar bahasa Indonesia dengan model Kooperatif Learning Tipe STAD sebanyak 2 siswa (6,5 %). Tindakan pada siklus 2 memberikan peningkatan sesuai dengan harapan dan memenuhi kriteria keberhasilan yang sudah ditentukan, karena siswa yang mendapat nilai di bawa KKM pada siklus ke 2 hanya 2 orang.
Obstacles of the Development of Innovative Business Ideas: A Survey on Students of Entrepreneurship Education
Authors: ÖZGÜL Engin , TURAN Nuray , TINAR Mustafa Yaşar
Published: March 2018

One of the most important conditions for the sustainable entrepreneurship process is to develop high potential innovative business ideas. The excess of these obstacles encountered at the beginning of the entrepreneurship process negatively affects the formation of qualified enterprises. In the study, the relationship between obstacles of business idea development, innovative levels of individuals, entrepreneurial competence, intention and potentials were examined. In the study of individuals graduating from the Entrepreneurship Academy of Dokuz Eylül University, entrepreneurship obstacles were collected in five different groups. According to the analysis results, there is a non-linear relationship between business idea obstacles and entrepreneurial potential, competence and intention and individual innovation level. According to this, it was found that the obstacle perception is the highest within the people who have moderate entrepreneurship intention and potential the groups with low intention and potential do not care about obstacles; the groups with highest intention and potential have lowest obstacle perception. Furthermore, it was stated that entrepreneurship intention, competence and innovation level were the significant predictors of entrepreneurship potential.
Seroprevalence of mycoplasmosis in poultry of Bhaktapur
Authors: Khanal Doj Raj , Ranjit Eliza , Adhikari Sanjeev Kumar , Ghemosu Bimal , Prajapati Meera , Shrestha Swoyam Prakash
Published: March 2018

Mycoplasmas are amongst the avian pathogens that causes chronic respiratory and joint diseases incurring a huge economic loss to poultry industry of Nepal. Among different species of Mycoplasmas, we investigate Mycoplasma gallisepticum-synoviae from the serum samples of the poultry using Enzyme Linked Immuno Sorbent Assay (ELISA) and dot-ELISA test of ImmunoComb. These tests rely on the antibodies present in the serum samples which binds to the pre-coated antigen in the ELISA/developing plates. A total of 92 sera samples were collected, of which 62 were from broiler and 30 were from layers. Of the 92 samples taken from different farms of Bhaktapur in early 2017, thirty (32.6%) were found positive on standard or routine ELISA and fifty-four (58.7%) on dot-ELISA. It further indicates high rate of infections in broiler (42 on dot-ELISA and 24 on standard ELISA) than in layers (12 in dot-ELISA and 6 on standard ELISA) to M. gallisepticum and M. synoviae. The present result indicates higher efficacy of dot-ELISA over standard one as the latter could not efficiently detect the infections as compared to the dot-ELISA. Furthermore, this finding poses an alarming threat to the commercial poultry industries of Nepal where there is lack of effective biosecurity practices and preventive vaccination policy.  Int. J. Appl. Sci. Biotechnol. Vol 6(1): 23-26
Adoption and Maintenance of Self Seed Sufficiency in Major Cereal Crops in Mid-Western Terai of Nepal
Authors: Chaudhary Ram Das , Yadav Bisheswar Prasad , Tripathi Santosh Raj , Poudel Padam Prasad , KC Govinda , Yadav Dinesh Kumar , Singh Indrapal
Published: March 2018

Regional Agricultural Research Station Nepalgunj (RARS/N) has its four major outreach sites in Satbariya Village Development Committee (VDC) of Dang, Betahani VDC of Banke, Mahammadpur VDC of Bardiya, Patharaiya VDC of of Kailali and model village in Mainapokhar VDC of Bardiya district for test and verify the acceptance of new released varieties under farmers' field condition and provide an opportunity to the farmers to select most suitable variety on their own choice based on performance. Seed was distributed throughout the OR sites and model village for newly released varieties for self seed sufficiency. New most recent varieties  of rice and wheat released in the previous year from concerned commodity research programme, National Rice Research Programme (NRRP), Hardinath and National Whear Research Programme (NWRP), Bhairawaha respectively, were selected. The yield attributing characters, total yield, percentage yield used as seed in the next fiscal year were recorded. Response of the participating farmers for various varieties with respect to various attributes of yield and other important criteria for sustainable cultivation were recorded in individual sheet. Agronomic management practices were done according to recommendation practices for particular crop. Rice varieties of Sukkha series adoption rate was increasing trend. Among them Sukkha Dhan 1, Sukkha Dhan 2 and Sukkha Dhan 3 adoption rate was higher. Wheat variety Gautam adoption rate was higher followed by NL 971.Int. J. Appl. Sci. Biotechnol. Vol 6(1): 38-44
Nutrient Expert Impact on Yield and Economic In Maize and Wheat
Authors: Dahal Sahara , Shrestha Abhisek , Dahal Sabina , Amgain Lal Prasad
Published: March 2018

The lower productivity and higher yield gaps in major cereals are the dominant problems of agriculture in eastern-terai of Nepal. Hence, field experiment was conducted to evaluate Nutrient Expert® wheat and maize model on farmer’s field at two sites each for maize and wheat in Morang and Jhapa district. The experiment was conducted in Randomized Completely Block Design replicated among twenty farmers in each district. Two treatments executed were NE (Nutrient Expert Recommendation) and FFP (Farmer Fertilizer Practices).The result revealed significant difference in terms of morphology, yield attributes and yield of wheat and maize. The highest wheat yield (4.71 ton ha-1) was obtained from NE followed by FFP (3.00 ton ha-1) in Jhapa and in Morang, was (4.01 ton ha-1) in NE followed by (2.05 ton ha-1) in FFP. In contrary, the higher maize yield (9.22 ton ha-1) was obtained from NE followed by FFP (4.94 ton ha-1) in Jhapa and (8.059 t ha-1)in Morang NE followed by FFP (4.52 ton ha-1). The net revenue of NE wheat in Morang was found to be increased by 344.799% while in maize the increment in net revenue of NE was only by 131.158% in Jhapa than in Morang. NE based practices produced significantly higher productivity and profitability in comparison with FFP.Int. J. Appl. Sci. Biotechnol. Vol 6(1): 45-52
Determination of qPCR Reference Genes Suitable for Normalizing Gene Expression in a Canine Model of Duchenne Muscular Dystrophy
Authors: Hildyard John C.W. , Taylor-Brown Frances , Massey Claire , Wells Dominic J. , Piercy Richard J.
Published: March 2018

Background:

Dogs with dystrophin-deficient muscular dystrophy are valuable models of the equivalent human disease, Duchenne Muscular Dystrophy (DMD): unlike the mdx mouse, these animals present a disease severity and progression that closely matches that found in human patients. Canine models are however less thoroughly characterised than the established mdx mouse in many aspects, including gene expression. Analysis of expression in muscle plays a key role in the study of DMD, allowing monitoring and assessment of disease progression, evaluation of novel biomarkers and gauging of therapeutic intervention efficacy. Appropriate normalization of expression data via carefully selected reference genes is consequently essential for accurate quantitative assessment. Unlike the expression profile of healthy skeletal muscle, the dystrophic muscle environment is highly dynamic: transcriptional profiles of dystrophic muscle might alter with age, disease progression, disease severity, genetic background and between muscle groups.

Objectives:

The aim of this work was to identify reference genes suitable for normalizing gene expression in healthy and dystrophic dogs under various comparative scenarios.

Methods:

Using the delta-E50 MD canine model of DMD, we assessed a panel of candidate reference genes for stability of expression across healthy and dystrophic animals, at different ages and in different muscle groups.

Results:

We show that the genes HPRT1, SDHA and RPL13a appear universally suitable for normalizing gene expression in healthy and dystrophic canine muscle, while other putative reference genes are exceptionally poor, and in the case of B2M, actively disease-correlated.

Conclusions:

Our findings suggest consistent cross-sample normalization is possible even throughout the dynamic progression of dystrophic pathology, and furthermore highlight the importance of empirical determination of suitable reference genes for neuromuscular diseases.