bluuebunny/crossref_metadata_2025 huggingface dataset:
Mitofusin-2 boosts innate immunity through the maintenance of aerobic glycolysis and activation of xenophagy in mice
Authors: Silwal Prashanta , Kim Jin Kyung , Jeon Sang Min , Lee June-Young , Kim Young Jae , Kim Yi Sak , Seo Yeji , Kim Jihye , Kim Soo Yeon , Lee Min Joung , Heo Jun Young , Jung Mi-Ja , Kim Hyun Sik , Hyun Dong-Wook , Han Jeong Eun , Whang Jake , Huh Yang Hoon , Lee Sang-Hee , Heo Won Do , Kim Jin-Man , Bae Jin-Woo , Jo Eun-Kyeong
Published: May 2021

Mitochondrial function and innate immunity are intimately linked; however, the mechanisms how mitochondrion-shaping proteins regulate innate host defense remains largely unknown. Herein we show that mitofusin-2 (MFN2), a mitochondrial fusion protein, promotes innate host defense through the maintenance of aerobic glycolysis and xenophagy via hypoxia-inducible factor (HIF)-1α during intracellular bacterial infection. Myeloid-specific MFN2 deficiency in mice impaired the antimicrobial and inflammatory responses against mycobacterial and listerial infection. Mechanistically, MFN2 was required for the enhancement of inflammatory signaling through optimal induction of aerobic glycolysis via HIF-1α, which is activated by mitochondrial respiratory chain complex I and reactive oxygen species, in macrophages. MFN2 did not impact mitophagy during infection; however, it promoted xenophagy activation through HIF-1α. In addition, MFN2 interacted with the late endosomal protein Rab7, to facilitate xenophagy during mycobacterial infection. Our findings reveal the mechanistic regulations by which MFN2 tailors the innate host defense through coordinated control of immunometabolism and xenophagy via HIF-1α during bacterial infection.
Mucosal ribosomal stress-induced PRDM1 promotes chemoresistance via stemness regulation
Authors: Kim Juil , Moon Yuseok
Published: May 2021

The majorities of colorectal cancer (CRC) cases are sporadic in origin and a large proportion of etiologies are associated with environmental stress responses. In response to external and internal stress, the ribosome stands sentinel and stress-driven ribosomal dysfunction triggers the cellular decision pathways via transcriptional reprogramming. In the present study, PR domain zinc finger protein (PRDM) 1, a master transcriptional regulator, was found to be closely associated with ribosomal actions in patients with CRC and the murine models. Stress-driven ribosomal dysfunction enhanced PRDM1 levels in intestinal cancer cells, which contributed to their survival and enhanced cancer cell stemness against cancer treatment. Mechanistically, PRDM1 facilitated clustering modulation of insulin-like growth factor (IGF) receptor-associated genes, which supported cancer cell growth and stemness-linked features. Ribosomal dysfunction-responsive PRDM1 facilitated signaling remodeling for the survival of tumor progenitors, providing compelling evidence for the progression of sporadic CRC.
Structural analogues in herbal medicine ginseng hit a shared target to achieve cumulative bioactivity
Authors: Zhang Wei , Tao Wei-Wei , Zhou Jing , Wu Cheng-Ying , Long Fang , Shen Hong , Zhu He , Mao Qian , Xu Jun , Li Song-Lin , Wu Qi-Nan
Published: May 2021

By a pilot trial on investigating immunomodulatory activity and target of ginsenosides, the major bioactive components of ginseng, here we report that structural analogues in herbal medicines hit a shared target to achieve cumulative bioactivity. A ginsenoside analogues combination with definite immunomodulatory activity in vivo was designed by integrating pharmacodynamics, serum pharmacochemistry and pharmacokinetics approaches. The cumulative bioactivity of the ginsenoside analogues was validated on LPS/ATP-induced RAW264.7 macrophages. The potentially shared target NLRP3 involved in this immunomodulatory activity was predicted by systems pharmacology. The steady binding affinity between each ginsenoside and NLRP3 was defined by molecular docking and bio-layer interferometry assay. The activation of NLRP3 inflammasomes in LPS/ATP-induced RAW264.7 was significantly suppressed by the combination, but not by any individual, and the overexpression of NLRP3 counteracted the immunomodulatory activity of the combination. All these results demonstrate that the ginsenoside analogues jointly hit NLRP3 to achieve cumulative immunomodulatory activity.
Supramolecular construction of a cyclobutane ring system with four different substituents in the solid state
Authors: Sinnwell Michael A. , Groeneman Ryan H. , Ingenthron Benjamin J. , Li Changan , MacGillivray Leonard R.
Published: May 2021

Methods to form cyclobutane rings by an intermolecular [2 + 2] cross-photoreaction (CPR) with four different substituents are rare. These reactions are typically performed in the liquid phase, involve multiple steps, and generate product mixtures. Here, we report a CPR that generates a cyclobutane ring with four different aryl substituents. The CPR occurs quantitatively, without side products, and without a need for product purification. Generally, we demonstrate how face-to-face stacking interactions of aromatic rings can be exploited in the process of cocrystallization and the field of crystal engineering to stack and align unsymmetrical alkenes in CPRs to afford chiral cyclobutanes with up to four different aryl groups via binary cocrystals. Overall, we expect the process herein to be useful to generate chiral carbon scaffolds, which is important given the presence of four-membered carbocyclic rings as structural units in biological compounds and materials science.
Novel fidaxomicin antibiotics through site-selective catalysis
Authors: Dailler David , Dorst Andrea , Schäfle Daniel , Sander Peter , Gademann Karl
Published: May 2021

Fidaxomicin (FDX) is a marketed antibiotic for the treatment ofClostridioides difficileinfections (CDI). Fidaxomicin displays antibacterial properties against many Gram-positive bacteria, yet the application of this antibiotic is currently limited to treatment of CDI. Semisynthetic modifications present a promising strategy to improve its pharmacokinetic properties and also circumvent resistance development by broadening the structural diversity of the derivatives. Here, based on a rational design using cryo-EM structural analysis, we implement two strategic site-selective catalytic reactions with a special emphasis to study the role of the carbohydrate units. Site-selective introduction of various ester moieties on the noviose as well as a Tsuji–Trost type rhamnose cleavage allow the synthesis of novel fidaxomicin analogs with promising antibacterial activities againstC. difficileandMycobacterium tuberculosis.
Perceptions of scientists held by US students can be broadened through inclusive classroom interventions
Authors: Sheffield Sarah L. , Cook Meghan L. , Ricchezza Victor J. , Rocabado Guizella A. , Akiwumi Fenda A.
Published: May 2021

More diverse representation in undergraduate classrooms may be an important step towards turning science, technology, engineering, and mathematics (STEM) disciplines into more inclusive communities. In the United States of America, the individuals whose work is discussed in typical introductory science courses collectively do not represent the diversity of students’ identities in the classroom and further reinforce existing stereotypes of scientists as male, white, and aged. Here we report on the implementation of a semester-long intervention in an introductory-level geoscience course at the University of South Florida, USA. We introduced students to individuals with marginalized identities who are either scientists or have had a major influence on science and conducted semi-structured interviews with students from the course’s previous semesters. Analyses of these interviews indicate that participants with marginalized and non-marginalized identities broadened their preconceptions of who belongs in science and the range of identities among scientists. We suggest that interventions like these could foster feelings of belonging in the STEM community and, with repeated efforts, reduce harmful stereotyping and microaggressions against underrepresented scientists.
Up-scalable emerging energy conversion technologies enabled by 2D materials: from miniature power harvesters towards grid-connected energy systems
Authors: Rogdakis Konstantinos , Karakostas Nikolaos , Kymakis Emmanuel
Published: May 2021

Emerging energy harvesters enabled by 2D materials distributed across different locations of an energy sustainable city, providing power for miniature IoT devices and contributing in on-grid electricity generation.
Conversion of cellulose to high-yield glucose in water over sulfonated mesoporous carbon fibers with optimized acidity
Authors: Yang Ying , Shao Shuai , Yang Feng , Brewe Dale L. , Guo Shangwei , Ren Dongcheng , Hao Shijie
Published: May 2021

Facilitated by superior mesoporous structure and rich functional groups, sulfonated mesoporous carbon fiber with optimized Brønsted and Lewis acidity delivers a high yield of glucose from cellulose hydrolysis in water.
Investigation of the influence of natural deep eutectic solvents (NaDES) in the properties of chitosan-stabilised films
Authors: Pontillo Antonella Rozaria Nefeli , Koutsoukos Spyridon , Welton Tom , Detsi Anastasia
Published: May 2021

In this work natural deep eutectic solvents are explored as versatile plasticisers for the formation of chitosan-stabilised films.
Metabolic engineering for plant natural products biosynthesis: new procedures, concrete achievements and remaining limits
Authors: Courdavault Vincent , O'Connor Sarah E. , Jensen Michael K. , Papon Nicolas
Published: May 2021

The recent achievements in the transfer of biosynthetic pathways of plant natural products in heterologous organisms offer new perspectives towards the supply of these compounds through metabolic engineering approaches.
Tuning the electrochemical performance of Ti3C2 and Hf3C2 monolayer by functional groups for metal-ion battery applications
Authors: Yang Zhifang , Zheng Yanping , Li Wenliang , Zhang Jingping
Published: May 2021

The S and Cl functionalized Mxenes can be used as a promising metal-ion batteries materials for a continuous flexible energy storage and conversion equipment.
Computational design of a switchable heterostructure electrocatalyst based on a two-dimensional ferroelectric In2Se3 material for the hydrogen evolution reaction
Authors: Kim Han Seul
Published: May 2021

The theoretical design of an ON–OFF switchable HER catalyst based on the two-dimensional ferroelectric material In2Se3 and transition metal cobalt.
An automatic flow-through system for exploration of the human bioaccessibility of endocrine disrupting compounds from microplastics
Authors: Sixto Alexandra , El-Morabit Bilal , Trujillo-Rodríguez María José , Carrasco-Correa Enrique Javier , Miró Manuel
Published: May 2021

Oral bioaccessibility of plastic migrants using automatic flow methodology.
Titanocene pnictinidene complexes
Authors: Fischer Malte , Reiß Fabian , Hering-Junghans Christian
Published: May 2021

Phospha– and arsa–Wittig reagent have been employed to synthesize titanocene complexes with terminal phosphinidene or arsinidene ligands, respectively.
Synthesis and optical and electronic properties of one-dimensional sulfoxonium-based hybrid metal halide (CH3)3SOPbI3
Authors: Tanaka Yuki , Bai Shiqiang , Wang Xizu , Tee Si Yin , Lim Siew Lay , Ke Lin , Dolmanan Surani B. , Lee Coryl Jing Jun , Lim Poh Chong , Yao Xiang , Wu Jishan , Han Ming-Yong
Published: May 2021

We report the synthesis and properties of a trimethylsulfoxonium-based hybrid metal halide. To provide insights, a method is developed to calculate tolerance factors using the ionic radii of non-spherical cations from X-ray crystallographic data.
Post-synthetic functionalization of tryptophan protected peptide sequences through indole (C-2) photocatalytic alkylation
Authors: Lima Rafaely N. , Delgado José A. C. , Bernardi Darlon I. , Berlinck Roberto G. S. , Kaplaneris Nikolaos , Ackermann Lutz , Paixão Márcio W.
Published: May 2021

Mild and efficient C–H functionalization of tryptophan and of tryptophan-containing peptides with activated α-bromo-carbonyl compounds under visible-light irradiation is described.
Iridium-catalyzed stereoselective [3+2] annulation of α-oxocarboxylic acids with 1,3-dienes
Authors: Yabe Ryota , Ebe Yusuke , Nishimura Takahiro
Published: May 2021

The stereoselective annulation of α-oxocarboxylic acids with 1,3-dienes proceeded in the presence of a hydroxoiridium catalyst to give α-hydroxy-γ-lactones in good yields with high 3,5-trans relative stereochemistry.
Light-induced switching of polymer-surfactant interactions enables controlled polymer thermoresponsive behaviour
Authors: Weißenborn Eric , Droste Jörn , Hardt Michael , Schlattmann Daniel , Tennagen Celine , Honnigfort Christian , Schönhoff Monika , Hansen Michael Ryan , Braunschweig Björn
Published: May 2021

Hydroxypropyl cellulose and arylazopyrazole mixtures for remote control of particle size and solution viscosity using light and temperature stimuli.
Driving a sustainable application of s-triazine ametryn and atrazine herbicides through multicomponent crystals with improved solubility
Authors: da Silva Amandha Kaiser , Diniz Luan F. , Tenorio Juan C. , Nazário Carlos E. D. , Ribeiro Caue , Carvalho Jr Paulo S.
Published: May 2021

Engineered multicomponent crystals of Atrazine and ametryn herbicides have shown enhanced solubility and can be an alternative for the production of safe and eco-friendly agrochemical products.
Catalyst-free growth of single- to few-layered graphene on ionic liquid surfaces at room temperature
Authors: Shen Jiawei , Gao Cheng , Ye Xuheng , He Yi , Tao Xiangming , Yang Bo , Wang Miao , Ye Gaoxiang
Published: May 2021

Single- to few-layered graphene is successfully fabricated on ionic liquid surfaces by a modified arc-discharge evaporation method without the assistance of catalysts and at room temperature.
Influence of the crystal packing in singlet fission: one step beyond the gas phase approximation
Authors: Aguilar Suarez Luis Enrique , de Graaf Coen , Faraji Shirin
Published: May 2021

Singlet fission (SF), a multiexciton generation process, has been proposed as an alternative to enhance the performance of solar cells.
Site-selective soft X-ray absorption as a tool to study protonation and electronic structure of gas-phase DNA
Authors: Wang Xin , Rathnachalam Sivasudhan , Bijlsma Klaas , Li Wen , Hoekstra Ronnie , Kubin Markus , Timm Martin , von Issendorff Bernd , Zamudio-Bayer Vicente , Lau J. Tobias , Faraji Shirin , Schlathölter Thomas
Published: May 2021

We identify protonation sites and study the competition of statistical fragmentation with localized bond cleavage after site-selective nitrogen 1s core-excitation by mass spectrometric detection of gas-phase oligonucleotide cations.
Active particle diffusion in convection roll arrays
Authors: Ghosh Pulak Kumar , Marchesoni Fabio , Li Yunyun , Nori Franco
Published: May 2021

Undesired advection effects are unavoidable in most nano-technological applications involving active matter.
A hierarchical ZSM-22/PHTS composite material and its hydro-isomerization performance in hydro-upgrading of gasoline
Authors: Fan Jiyuan , Xiao Chengkun , Mei Jinlin , Liu Cong , Duan Aijun , Li Jianmei , Liu Jian , Zhang Min
Published: May 2021

The ZSM-22/PHTS (ZP) composite material assembled from a ZSM-22 zeolite crystal displayed a mesoporous structure. The CoMo/ZPA120 catalyst presented a good balance between HDS activity (95.2%) and lower ΔRON (−1.1).
Hierarchical core–shell 2D MOF nanosheet hybrid arrays for high-performance hybrid supercapacitors
Authors: Bi Qiong , Ma Qingxiang , Tao Kai , Han Lei
Published: May 2021

Hierarchical core–shell 2D MOF nanosheet hybrid arrays have been synthesized by a facile strategy, showing high specific capacitance in SCs.
Reducing the allergenicity of pea protein based on the enzyme action of alcalase
Authors: Ding Jie , Ju Huapeng , Zhong Limin , Qi Libo , Sun Na , Lin Songyi
Published: May 2021

Enzymatic hydrolysis, isolation and purification could availably reduce the allergenicity of pea protein and peptides.
Self-healing polymer–clay hybrids by facile complexation of a waterborne polymer with a clay
Authors: Teepakakorn Aranee (Pleng) , Ogawa Makoto
Published: May 2021

A water-induced self-healing polymer hybrid was prepared by the hybridization of poly(vinyl alcohol) with the smectite clay in aqueous media and subsequent casting.
A water-soluble copper-immobilized covalent organic framework functioning as an “OFF–ON” fluorescent sensor for amino acids
Authors: Ahmed Lamiaa Reda , EL-Mahdy Ahmed F. M. , Pan Cheng-Tang , Kuo Shiao-Wei
Published: May 2021

A fluorescent hydroxyl- and hydrazone-based covalent organic framework (TFPB–DHTH COF) was synthesized as an “OFF–ON” fluorescent sensor for cysteine and l-histidine.
Tunable and ordered porous carbons with folding-like nanoscale framework via interdigitation and twisting
Authors: Kubo Shiori
Published: May 2021

A sustainable, sugar-based hydrothermal synthesis generates highly entangled, yet controlled porous carbonaceous frameworks via interdigitation and twisting of layered phases.
A nano interlayer spacing and rich defect 1T-MoS2 as cathode for superior performance aqueous zinc-ion batteries
Authors: Cai Chengyan , Tao Zengren , Zhu Yuanfei , Tan Yuanming , Wang Anding , Zhou Haiyun , Yang Yangyi
Published: May 2021

A simple hydrothermal method is used to synthesize molybdenum disulfide with nano-level interlayer spacing, which effectively improves the zinc storage performance as a cathode electrode in aqueous zinc-ion batteries.
Pyrene based materials as fluorescent probes in chemical and biological fields
Authors: Ayyavoo Kannan , Velusamy Praveena
Published: May 2021

Molecules that experience a change in their fluorescence emission due to the effect of fluorescence enhancement upon binding events, like chemical reactions or a change in their immediate environment, are regarded as fluorescent probes.
Agricultural waste buckwheat husk derived bifunctional nitrogen, sulfur and oxygen-co-doped porous carbon for symmetric supercapacitors and capacitive deionization
Authors: Li Guanfeng , Yang Fan , Wu Lisha , Qian Lei , Hu Xiaorong , Wang Zaimin , Chen Wen
Published: May 2021

A practical strategy for the value-added utilization of agricultural waste was provide. The buckwheat husk derived N, S, O-co-doped porous carbon was used as bifunctional electrode materials for symmetric supercapacitor and capacitive deionization.
Incorporating W cations into ZnO nanosheets: an efficient method towards ZnO/ZnWO4 photocatalysts for highly effective degradation of organic compounds under UV and visible-light irradiation
Authors: Ben Soltan Wissem , Wang Wenlong , Sun Jing , Toupance Thierry , Yu Guanqun , Li Faqi
Published: May 2021

Novel ZnO/ZnWO4 photocatalysts were synthesized for the removal of RhB dye with an excellent photocatalytic performance.
Non-noble metallic Cu with three different roles in a Cu doped ZnO/Cu/g-C3N4 heterostructure for enhanced Z-scheme photocatalytic activity
Authors: Bajiri Mohammed Abdullah , Hezam Abdo , Namratha K. , Al-Maswari Basheer M. , BhojyaNaik H. S. , Byrappa K. , Al-Zaqri Nabil , Alsalme Ali , Alasmari Raghad
Published: May 2021

Cu serves as a co-catalyst, an electron mediator, and a dopant leading to a high enhancement in the photocatalytic activity of Cu-ZnO/Cu/g-C3N4 Z-scheme photocatalyst.
Combination of full-coverage Sb2S3 thin films and spiro-OMeTAD:P3HT hybrid hole transporting materials for efficient solar cells
Authors: Yang Yang , Shi Chengwu , Lv Kai , Wang Qi , Sun Xun , Chen Wangchao
Published: May 2021

The Sb2S3 solar cell with a full-coverage Sb2S3 thin film and high-hole-mobility spiro-OMeTAD:P3HT hybrid hole transporting material achieved a PCE of 5.65%.
Exploring an efficient manganese oxide catalyst for ozone decomposition and its deactivation induced by water vapor
Authors: Fang Chentao , Li Dandan , Wang Xufang , Wang Yuejuan , Chen Jian , Luo Mengfei
Published: May 2021

A series of MnOx catalysts supported by carbon spheres were prepared by calcining mixtures of manganese acetate and carbon spheres under a nitrogen atmosphere, and their performance for ozone decomposition under high humidity conditions (RH = 90%) was evaluated.
Visible light-induced alkylpyridylation of styrenes via a reductive radical three-component coupling
Authors: Yu Jing-miao , Zhu Li-wen , Hong Xiao-yuan , Gao Huan , Chen Ting-ting
Published: May 2021

A visible light-induced and metal-free strategy for the intermolecular three-compoment alkylpyridylation of styrenes is reported.
Chemoselective synthesis of 5,4′-imidazolinyl spirobarbiturates via NBS-promoted cyclization of unsaturated barbiturates and amidines
Authors: Xu Hui , Huang Rong-Lu , Shu Zhu , Hong Ran , Zhang Ze
Published: May 2021

The cyclization of unsaturated barbiturates and amidines promoted by N-bromosuccinimide furnished a variety of structurally novel 5,4′-imidazolinyl spirobarbiturates with high chemoselectivity, good yields and remarkable functional group tolerance.
“Click” dendrimer-Pd nanoparticle assemblies as enzyme mimics: catalytic o-phenylenediamine oxidation and application in colorimetric H2O2 detection
Authors: Liu Yue , Lopes Renata Pereira , Lüdtke Tanja , Di Silvio Desire , Moya Sergio , Hamon Jean-René , Astruc Didier
Published: May 2021

“Click” dendrimer-Pd NPs as peroxidase enzyme mimics of H2O2 sensing using o-phenylenediamine oxidation by H2O2 to 2,3-diaminophenazine.
Advancements in the preparation methods of artificial cell membranes with lipids
Authors: Yuan Wei , Piao Jiafang , Dong Yuanchen
Published: May 2021

In order to better understand the structure and function of biological cell membranes, various artificial systems have been developed.
Iminyl radical initiated sulfonylation of alkenes with rongalite under photoredox conditions
Authors: He Fu-Sheng , Zhang Man , Zhang Mengke , Luo Xiangxiang , Wu Jie
Published: May 2021

A photoredox-catalyzed reaction of oximes, rongalite and electrophiles is accomplished, affording pyrrole-substituted aliphatic sulfones or sulfonamides in moderate to good yields.
Boron-catalyzed dehydrative allylation of 1,3-diketones and β-ketone esters with 1,3-diarylallyl alcohols in water
Authors: Zhang Guo-Min , Zhang Hua , Wang Bei , Wang Ji-Yu
Published: May 2021

Allylic alcohols can directly dehydrated in water by B(C6F5)3, without any base additives.
Increasing structural and functional complexity in self-assembled coordination cages
Authors: Pullen Sonja , Tessarolo Jacopo , Clever Guido H.
Published: May 2021

This review highlights recent strategies towards the rational synthesis of metallo-supramolecular multicomponent systems, the implementation of functionality and the challenge to create multifunctional assemblies in non-statistical fashion.
Facile solvent-free synthesis of multifunctional and recyclable ionic conductive elastomers from small biomass molecules for green wearable electronics
Authors: Dang Chao , Peng Fang , Liu Hongchen , Feng Xiao , Liu Yu , Hu Songnan , Qi Haisong
Published: May 2021

Small biomass molecules, α-lipoic acid (LA) and itaconic acid (TA), are directly converted into ionic conductive elastomers (ICE) by a one-step strategy. The integrated performances and full recyclability make the ICE usable to green flexible electronics.
Controlling phase separation in thermoelectric Pb1−xGexTe to minimize thermal conductivity
Authors: Lian Hong , Kumar Anil , Ocelík Václav , Baas Jacob , Momand Jamo , Kooi Bart J. , Blake Graeme R.
Published: May 2021

The density of interfaces in spinodally decomposed Pb1−xGexTe can be controlled, allowing thermal conductivity to be optimized for thermoelectric performance.
Modulation of inflammation by anti-TNF α mAb-dendrimer nanoparticles loaded in tyramine-modified gellan gum hydrogels in a cartilage-on-a-chip model
Authors: Oliveira I. M. , Carvalho M. R. , Fernandes D. C. , Abreu C. M. , Maia F. R. , Pereira H. , Caballero D. , Kundu S. C. , Reis R. L. , Oliveira J. M.
Published: May 2021

A human 3D inflammatory cartilage-on-a chip model was develop as a drug screening platform to evaluate the therapeutic efficacy of anti-TNFα mAb-CS/PAMAM dendrimer NPs loaded-Tyramine-Gellan Gum Hydrogel.
Molecular design opening two emission pathways for high efficiency and long lifetime of thermally activated delayed fluorescent organic light-emitting diodes
Authors: Lee Ha Lim , Lee Kyung Hyung , Lee Jun Yeob , Lee Ho Jung
Published: May 2021

High efficiency and long lifetimes of thermally activated delayed fluorescent organic light-emitting diodes were developed using a novel molecular design with two emission pathways.
Micro-/nano-sized multifunctional heterochiral metal–organic frameworks for high-performance visible–blind UV photodetectors
Authors: Shang Xiaobo , Song Inho , Jung Gwan Yeong , Choi Wanuk , Ohtsu Hiroyoshi , Lee Jeong Hyeon , Ahn Jaeyong , Koo Jin Young , Kawano Masaki , Kwak Sang Kyu , Oh Joon Hak
Published: May 2021

Multifunctional heterochiral micro-/nano-sized metal–organic framework single crystals are developed for high-performance visible–blind UV photodetection.
WITHDRAWN: Remifentanil preconditioning alleviates myocardial ischemia/reperfusion injury in rats via activating Jagged-1/Notch signaling pathway
Authors: Cao Dejun , Liu Shaoxing , Yang Mengchang , Xie Keyu , Zheng Zhuo , Wen Hucheng , Xie Xianfeng
Published: May 2021

The Accepted Manuscript version of this article (published on 10 May 2021) was withdrawn on 30 June 2021. Following the acceptance of this article, one of the Editors-in-Chief of the Brazilian Journal of Medical and Biological Research alerted the Editorial Office of Bioscience Reports that this paper was submitted to and considered simultaneously in both journals. This goes against the Editorial Polices of Bioscience Reports, hence the accepted article has been withdrawn.
Influencing Factors of Investment Scale of Power Grid Enterprises
Authors: Liyu Xia , Wan He , Qian Zhang , Bingxin Zeng
Published: May 2021

Investment is the key driving force for the sustainable growth of power grid enterprises. The rationality of investment scale directly determines the investment efficiency, and affects the quality of enterprise growth. The internal and external environment of investment management of power grid enterprises is constantly changing. Scientific judgment of the importance of various influencing factors can provide strong support for the determination of investment scale. In this paper, the factors affecting the investment scale of power grid enterprises are divided into economic and social development, product industry development, enterprise operation and management, and power grid operation and development. Representative indicators are selected for analysis, and the influence degree of various influencing factors is judged by correlation coefficient test and variable importance evaluation method. The empirical results show that the enterprise management and power grid operation and development have greater impacts on the investment scale. The influence of internal factors is greater than that of external factors.
Adaptability and Countermeasures of HVDC line protection under the UHVDC system with multiple receiving ends
Authors: Chen Zhengguang , Wang Xingguo , Wang Shuyang , Cao Hong
Published: May 2021

In UHVDC transmission system, the inverter station is located in different geographical locations, and there are two sections of lines in single pole of HVDC system, which brings challenges to the traditional closed line protection. In this paper, firstly, the structural characteristics of series connection mode and the output characteristics of each converter in case of line fault are analysed, and the adaptability of conventional line protection in series multiple receiving ends system is studied. According to the characteristics of UHVDC system with multiple receiving ends in series connection mode, a hierarchical protection strategy is proposed and verified in PSCAD model.
Short-term power load forecasting based on combined kernel Gaussian process hybrid model
Authors: Lingyu Liang , Huang Wenqi , Dong Zhaojie , Zhao Jiguang , Li Peng , Lu Bingfang , Zhu Xinde
Published: May 2021

As one of the countries with the most energy consumption in the world, electricity accounts for a large proportion of the energy supply in our country. According to the national basic policy of energy conservation and emission reduction, it is urgent to realize the intelligent distribution and management of electricity by prediction. Due to the complex nature of electricity load sequences, the traditional model predicts poor results. As a kernel-based machine learning model, Gaussian Process Mixing (GPM) has high predictive accuracy, can multi-modal prediction and output confidence intervals. However, the traditional GPM often uses a single kernel function, and the prediction effect is not optimal. Therefore, this paper will combine a variety of existing kernel to build a new kernel, and use it for load sequence prediction. In the electricity load prediction experiments, the prediction characteristics of the load sequences are first analyzed, and then the prediction is made based on the optimal hybrid kernel function constructed by GPM and compared with the traditional prediction model. The results show that the GPM based on the hybrid kernel is not only superior to the single kernel GPM but also superior to some traditional prediction models such as ridge regression, kernel regression and GP.
Multi Step Transient Hybrid Simulation Framework Design and Practical Engineering Application for AC / DC Power Grid
Authors: Weijie Zheng , Dechao Xu , Yong Chen , Xing Zhang , Qing Mu
Published: May 2021

Based on the large power grid simulation and the existing security prevention and control mode, this paper further integrates the multi-step transient hybrid simulation architecture computing technology to research the high-performance analysis and situational awareness simulation technology of interconnected AC / DC large power grid security and stability characteristics. So as to realize the “panoramic situational awareness, wide area coordinated control, flexible and efficient service” of large power grid, and improve the super large scale power grid Comprehensive security defense and intelligent monitoring level of panoramic, multi-dimensional and three-dimensional.
Optimal Planning of Active Distribution Network Based on Soft Open Point and Shunt Capacitors
Authors: Yang Haiyue , Yu Lu , Zhao Qianyu , Wang Hu , Du Zongwei , Jie Bai
Published: May 2021

As the penetration of distributed wind power in the distribution network continues to increase, the uncertainty of its output has a serious impact on the stable operation of the distribution network. It is difficult to meet the voltage regulation requirements when the wind power fluctuates frequently only by relying on shunt capacitors. Therefore, a coordinated optimization planning method based on soft open point (SOP) and shunt capacitors is proposed. Firstly, the bidirectional generative adversarial network (BIGAN) is used to characterize the uncertainty of wind power output and generate typical scenarios of wind power output. Secondly, a multi-objective optimization planning model of SOP and shunt capacitors is proposed based on the scene analysis method; Then, a solution strategy based on the improved elitist non-dominated sorting genetic algorithm (NSGA-II) is proposed. Finally, the proposed planning model and solution are verified and analyzed in the improved IEEE 33-bus system.
Research on On-line Monitoring Technology of Secondary Equipment in Smart Substation
Authors: Shen Hongming , Yan Peili , Feng Teng , Wang Ziqi , Liu WenXuan , Jiang Jing , Liu Min , Du Na
Published: May 2021

First, the overall design principles of the online monitoring of secondary equipment in smart substations are studied. Then, the overall architecture of online monitoring of secondary equipment is proposed. Finally, the advanced application of the online monitoring system of secondary equipment is analyzed. The method proposed in this paper improves the online monitoring and management level of secondary equipment, and provides technical support for the regulation and condition maintenance of secondary equipment.
MATLAB Simulation Research on Static Var Compensator
Authors: Chen JinBo , Hu WenYu
Published: May 2021

TCR-TSC static reactive power compensator (SVC) is the most widely used in the field of power system reactive power compensation. This type of reactive power compensator can not only compensate the reactive power required in the power system, but also handle the over-compensation problem well. This paper will establish a MATLAB simulation model to simulate the TCR-TSC SVC, focusing on the dynamic reactive power compensation characteristics of the TCR-TSC SVC in suppressing voltage fluctuations. The simulation results show that the TCR-TSC SVC has a better dynamic reactive power compensation effect.
Fault Location Method for Two-Terminal Untransposed Overhead Lines in Distribution Networks Measured by μMPMU
Authors: Wen Tao , Zhang Fangxu , Wang Chengbin
Published: May 2021

With the rapid development of distribution networks, two-terminal overhead lines have been used on a large scale for higher power supply reliability, thus the fault location has attracted much attention. Accurate fault location is helpful to shorten the outage time and improve the economy of operation greatly. However, since insufficient standardization of equipment selection and poor management, line parameters are usually inaccurate or even unknown, mature fault location methods based on impedance can’t be applied anymore. Also, the asymmetry caused by non-transposition in distribution networks affects the accuracy of fault location. This paper proposes a fault location method for two-terminal untransposed overhead lines without requiring line parameters. Firstly, this paper considers parameter asymmetry, and the mutual impedances between the three phases are set as different values. Secondly, the location equations rely on three-phase networks, then the self-impedance and mutual impedances are regarded as unknowns and solved directly. Finally, this method takes the average value of fundamental frequency components from different data windows, which reduces error and improves accuracy. The simulation results show that the fault location method has high accuracy, and can effectively overcome the influence of unknown line parameters and non-transposition.
A kind of DC fault current-limiter with instantaneous by-pass of current-limiting reactor
Authors: Deng Jinyi , Li Chen , Gao Junfeng
Published: May 2021

With the rapid development of DC power grids, the protection of DC power grids is particularly important. Therefore, this paper proposes a kind of DC fault current-limiter with instantaneous by-pass of current-limiting reactance, analyses its working principle and theoretical calculations, and verifies the correctness of its principle through simulation experiments. At the same time, the experimental results show that the current-limiter proposed in this paper can not only instantaneously and greatly limit the fault current when a short-circuit fault occurs in the power grid, but not affect the normal operation of the power grid. A new device is provided for DC gird fault current-limiting protection.
Research on Operating Characteristics of Two-Terminal Flexible Direct Transmission with Improved Deadbeat Control
Authors: Jianchun Mei , Junxia Qian , Shengjie Zhao , Hongjuan Ma , Pengcheng Song , Zhoupeng Shen
Published: May 2021

Traditional DC transmission technology has obvious defects in power adjustment speed, loss reduction, protection and control, etc., and it has been unable to meet the diverse needs of electricity consumption. The flexible DC transmission system not only solves the above shortcomings, but also has the advantages of independently controllable power and power supply to passive network. It is widely applied in distributed power generation by new energy, micro grid and other fields. This paper takes the two-terminal flexible DC transmission system as the research object, establishes the mathematical mode of two-terminal flexible DC transmission system, and studies the basic operation mode of the system and the voltage source converter (VSC) control strategy on this basis. Considering the problems of control delay and poor responsiveness of current closed-loop control when the traditional deadbeat control is applied to VSC converters, an improved deadbeat control strategy is proposed to solve the above-mentioned defects by predicting the current sampling at k+2 moment. Finally, the co-simulation is used to verify the correctness and reliability of the above-mentioned method.
Tracking error analysis of primary mirror in Linear Fresnel heat collecting field
Authors: ZhiYong Zhang , LingGang Kong , DuoJin Fan , XiaoMing Yao
Published: May 2021

Aiming at the tracking error of the primary mirror in the Linear Fresnel concentrated light and heat field, according to the structural characteristics of the Linear Fresnel concentrating and heat collecting system, the analysis model of the system concentrating error is established. By analyzing the mirror shape error of the Linear Fresnel system, the installation error of the secondary mirror (CPC), the errors of the north-south layout of the mirror field, the deviation of the primary mirror rotation axis and the deviation of the temperature drift of the angle sensor, and the factors were calculated by MATLAB simulation. The concentrating error factors affecting the Linear Fresnel concentrating and heat collecting system are analyzed quantitatively. From the simulation results: during the whole day, the influence of the north-south layout deviation of the mirror field and the deviation of the primary mirror rotation axis on the tracking accuracy is time-varying, and the influence is greater in the midday period. During the whole year, the influence factors of the north-south deviation of the mirror field and the temperature drift of the angle sensor on the tracking accuracy are incident, and the influence is greater in winter and less in summer. The installation error of CPC has a constant influence on the tracking accuracy.
Optimization of electric heating operation based on day-ahead electricity spot market
Authors: Li Chengyuan , Jang Limin , Qin Yu
Published: May 2021

The emergence of Electricity Spot Market makes it possible that distributed electric heating equipment connect with the grid and participate in market competition as well. However, due to the functional limits, it is impossible for the power supply side to have a thorough understanding of the specific conditions of the load characteristics of the power user, and the user side will not take a global consideration of the real-time security and stability of the power grid. This paper focuses on the research about electricity consumption strategy of thermoelectric coupled load with the background of electricity spot market. The main works are as following: An operation strategy of consumer electric heating equipment based on electric spot market is proposed. Besides, an operation mode which responds to the market is obtained by analysing the time span of clearing nodes in power spot market and start-stop characteristics of distributed heat load equipment. Based on this, the operating cost control function of consumer electric heating load is designed, making it possible that the load follows changes of the clearing price under the premise of ensuring that the user’s heat demand is met within a day. Then we had a discussion about the impact of parameter changes on the operating strategy. With the help of the constraints of existing power grid, the operation strategy model of consumer electric heating equipment based on power spot market is realized.
A Multi-Functional De-Icing Equipment Using Hybrid Type Parallel Current Source Converters
Authors: Hu Yang , Zhang Heng , Chen Jing , Zhang Huan , Liu Xinmeng , Li Jiachen , Chen Hanyu , Hu Haiyang
Published: May 2021

This paper has proposed a phase controlled and PWM controlled power current source converter (CSC) for transmission line de-icing. The proposed system consists of a high-power thyristor-based line commutated converter to contribute a majority of the dc de-icing current and a low power PWM CSC to provide a part of the dc de-icing current and to compensate the low order harmonic ac current from the TCR. Thus, the grid current can be highly sinusoidal. In order to avoid the resonance caused by the interaction between TCR and PWM CSC, a virtual impedance control is implemented in the PWM CSC without using any additional sensors. Comprehensive verification results have been obtained to validate the correctness of the proposed approach.
Defect Analysis of Secondary Equipment Based on Power Dictionary and Apriori Algorithm
Authors: Mu Jinshuang , Gao Zhanjun , Zhou Fengyuan
Published: May 2021

In order to improve the operation level and maintenance efficiency of the secondary equipment in the power system, based on the historical defect data, starting from the efficiency of data processing, power system need to build electricity dictionary. In the process of describing and processing the defect data, based on the electric power dictionary, the key characteristics of the defect data can be effectively extracted. From the perspective of data mining, this paper use Apriori algorithm to correlate and analyze the defect data, establish a analysis model for the secondary equipment defect data. Take a provincial electric power company’s secondary equipment historical defect data mining as an example, describes the application process and analysis method of Apriori algorithm. The results show that the algorithm can effectively dig out familial defects and find the weakness of the equipment, it has a certain guiding role for the improvement of equipment performance and secondary equipment operation, maintenance and overhaul.
An Evaluation Method for Commutation Failure Caused by Waveform Distortion
Authors: Zhou Hao , Su Can , Zhou Hao
Published: May 2021

Commutation failure is a key issue that affects the safe operation of HVDC transmission systems. Scholars at home and abroad have conducted research on the mechanism, evaluation indicators, and control strategies of commutation failure. However, most of the researches are aimed at the working conditions of commutation failure caused by a short-circuit fault on the AC side. There are few studies on the commutation failure caused by the harmonic injection on the AC side and the distortion of the AC bus voltage waveform. This paper clarifies the mechanism of commutation failure caused by waveform distortion, and proposes an index of harmonic commutation margin. On this basis, an evaluation method for commutation failure caused by waveform distortion is proposed. By predicting the commutation voltage-time area and optimization methods to assess whether the current voltage conditions have the risk of commutation failure. Finally, an electromagnetic transient simulation model is established on PSCAD/EMTDC, and the evaluation method in this chapter is verified by simulating the working conditions of the inverter side bus voltage waveform distortion. The results show its effectiveness in evaluating the commutation failure. The research provides a theoretical basis to the implementation of the control function and has broad engineering application prospects.
Research on Optimal Coordination and Algorithms of Microprocessor-based Inverse Time Backup Protection
Authors: Wang Xiaoyang , Li Zhongqing
Published: May 2021

Backup protection plays an important role in the safe operation of power grid, and it has important research value in the field of power system relay protection. Firstly, the research status and development opportunities of inverse time limit protection are analyzed, and then the best cooperation between inverse time limit protection and distance protection is discussed theoretically. According to the time constraint relationship in the protection range, an objective function satisfying the selectivity and speed is proposed. Secondly, in view of the difficulty in calculating the inverse time characteristic curve, a processing algorithm combining Taylor expansion method and look-up table method is proposed. Finally, the effectiveness and practicability of the method are verified by simulation experiments.
A Calculation Method of Available Transmission Capacity for Medium and Long-term Electricity Trading
Authors: Shi Fei , Feng Shuhai , Zheng Hengfeng , Wang Liwen , Wu Xu
Published: May 2021

In view of the fact that China’s power dispatching agencies and trading centers are relatively independent, but the medium and long-term power transactions need physical execution, which leads to higher requirements for transaction security boundary, this paper proposes a calculation method of available transmission capacity for medium and long-term power transactions, which calculates the available transmission capacity of transmission channels through probabilistic method to improve the enforceability of transaction results. Numerical simulation results also verify the effectiveness of the algorithm.
Failure diagnosis of the steam generator based on improved BP network and Particle
Authors: Qi Fujun , Niu Qingsong , Peng Jing , Tian Zhiguang
Published: May 2021

In order to overcome the problems of slow rate of convergence and falling easily into local minimum in BP algorithm, this paper introduces the adaptive particle swarm optimization algorithm and combining model. The paper applies it to steam turbine-generators fault diagnosis. The experiment data shows that the algorithm converges quickly and recognizes faults efficiently; it has a reference value for faults diagnosis.
Plastische Deckung eines ausgedehnten Defekts nach Entfernung zweier kutaner Plattenepithelkarzinome mittels doppeltem vaskularisierten Brückenlappen am Skalp
Authors: Heim Nils , Wilms Christian Tim
Published: May 2021

Generell stellt die Deckung von ausgedehnten Defekten am Skalp eine große Herausforderung dar. Bei großen Defekten spielen ästhetische und funktionelle Faktoren wie Kompromittierung der Perfusion der Lappenplastiken nach Tumorresektion, natürliches Angebot an Gewebe zur Deckung bei Rotationslappenplastiken aber auch der Verlauf der natürlichen Haargrenze eine Rolle, die die erfolgreiche Deckung erschweren. Wir berichten über den interessanten Fall eines Patienten, der sich mit einem etwa 8 × 9 cm großen kutanen Plattenepithelkarzinom des Skalps vorstellte. Nach histologischer Sicherung und Bestimmung von Größe und Topografie des Befunds mittels Schichtbildgebung erfolgte die chirurgische Entfernung des bis in den Sinus sagittalis superior reichenden Befundes. Die Deckung des großen Defekts erfolgte mit zwei doppelt gestielten Brückenlappen welche in fronto-occipitaler und occipito-frontaler in gegenläufiger Richtung in den zentralen Defekt geschwenkt wurden. Diese Art der doppelten Brückenlappenplastik stellt eine suffiziente Möglichkeit der Defektdeckung für Defekte der beschriebenen Art dar.