bluuebunny/crossref_metadata_2025 huggingface dataset:
Motor Ability of Deaf and Scientific Children
Authors: Sufitriyono Sufitriyono , Suherman Wawan Sundawan , Rismayanthi Cerika , Syafruddin Muhammad Akbar
Published: October 2023

This research is descriptive research using a survey method with test techniques. The sample was taken purposively as a sample of 16 children with special needs who were deaf and mentally retarded. Research data collection was carried out through tests, tests for gross motor skills consisted of a test for walking on a straight line for 5 meters, a test for running to avoid 5 obstacles for a distance of 15 meters, a test for standing on one leg for 10 seconds, a test for jumping from a high beam. 15 cm, and sprint 40 meters. From the gross motor skills test of deaf and mentally retarded children in Makassar City, the results obtained were that the gross motor skills of deaf and mentally retarded children were in the medium category, namely 8 students or 88.9% and 7 students or 100% respectively. From this, researchers can conclude that the gross motor skills of deaf and mentally retarded children in Makassar City are in the medium category
Survival Analysis of Students Not Graduated on Time Using Cox Proportional Hazard Regression Method and Random Survival Forest Method
Authors: Arib Muhammad Arib Alwansyah
Published: October 2023

Higher education is a place to educate the next generation of the nation in terms of academic and non-academic. Basically every college tries to maximize the graduation of its students, both in quantity and quality. The undergraduate education program is targeted to complete 8 semesters of study or can also be taken in less than 8 semesters and a maximum of 14 semesters. Many factors are thought to affect the length of student study, both internal and external factors. Based on the factors that are thought to affect the length of study of the student, it is necessary to conduct research to determine what factors have a significant effect on the length of study of the student. The method that can be used to determine these factors is survival analysis using cox proportional hazard regression and random survival forest. Factors that affect the length of study using cox proportional hazard regression is GPA, while by using the random survival forest method, the factors that influence the length of study of students are GPA, gender, and part time. Based on the comparison using the C-Index method, random survival forest is a suitable method to use in the data because the C-Index error value is 26.9% which is smaller than the cox proportional hazard which is 27.8%.
Qual a relação entre o uso de análogos de GLP- 1 e o tratamento da obesidade?
Authors: Malta Luana Mazza , Cacau Bianca Lopes , Santos Livia Rocha , Lyra-Pereira Juliana , Remédios Graziela Santos dos , Sousa Marcus Vinicius Santos e , Araújo Andressa Lianna Soares de Carvalho , Rocha Jamilly Santiago , Lima Bruno Walison Pontes Ribeiro , Mendes Érica de Araújo Silva
Published: October 2023

A obesidade é um problema global de saúde pública, que se encontra em crescente número de casos. Essa doença se associa com uma alta morbimortalidade na população e se associa com várias patologias, como diabetes mellitus tipo 2 e doenças cardiovasculares. A principal intervenção terapêutica para essa condição é a mudança do estilo de vida, contemplada pela prática de exercícios físicos, aliada a dietas hipocalóricas. No entanto, muitos pacientes não obtêm êxito no tratamento dessa enfermidade, devido a laboriosidade e aos fatores psicossociais intrínsecos a essa enfermidade. Nesse cenário, os análogos de GLP-1 surgem como medicamentos eficazes no tratamento da obesidade em pacientes que não têm melhoria com as mudanças do estilo de vida isoladamente. Diante disso, o artigo em questão tem como objetivo discutir a relação do uso dos análogos de GLP-1 e o tratamento da obesidade, enfatizando seus efeitos na perda de peso e suas limitações. Trata- se, portanto, de uma revisão integrativa de literatura, que se pautou em parâmetros como: elaboração da pergunta norteadora e palavras-chave, critérios de inclusão e exclusão, coleta de dados e análise crítica dos estudos incluídos. Para isso, foram utilizados estudos dos últimos 5 anos que respondiam à pergunta norteadora e se adequavam aos critérios de inclusão e exclusão. O presente estudo, portanto, evidencia que os agonistas do GLP-1 possuem efeitos sobre a redução de peso, glicemia e risco cardiovascular.
Macrossomia fetal como complicação da diabetes gestacional e a eficácia da dieta e exercícios físicos como tratamento primário: Revisão de literatura
Authors: Pivoto Giovanna Paola de Rezende , Silva Laura Ferreira Riêra da , Oppenheimer Drauzio
Published: October 2023

A diabetes mellitus gestacional (DMG) é uma doença metabólica caracterizada por níveis elevados de glicose no sangue na gestação, sendo a macrossomia fetal (MF), a complicação mais prevalente, resultando complicações no parto, como traumatismo perineal e cesariana de emergência. Este estudo busca analisar as principais complicações da DMG, fatores de risco associados e consequências para a saúde da mãe e do feto, abordando dieta e os exercícios físicos como tratamento primário. A revisão utilizou estudos publicados entre 2006 e 2022, selecionados nas bases de dados PubMed, SciELO, Google Scholar e BVS. Evidencia-se que a dieta e os exercícios físicos são eficazes no controle da DMG, podendo ser usados como tratamento inicial. No entanto, em alguns casos, o uso de medicamentos hipoglicemiantes pode ser necessário. Portanto, a dieta e a atividade física são fundamentais no tratamento da DMG, mas uma abordagem individualizada pode exigir intervenções medicamentosas.
The polarity and shape of the T wave in lead V-10 in Chihuahuas
Authors: Almeida Gustavo Luiz Gouvêa de , Almeida Marcelo Barbosa de , Santos Ana Carolina Mendes dos , Vargas Ângela , Ballot Sophie
Published: October 2023

The T-wave in the canine electrocardiogram can be positive, negative, or biphasic in most leads, while his amplitude should not be greater than 25% of the R wave. However, since the 1960’s persists controversy regarding the polarity of the T wave in Chihuahuas when compared to other canine breeds. This study aimed to clarify the polarity and shape of the T-wave in the lead V-10 in a group of healthy Chihuahuas. Retrospective eletrocardiographic study with a sample of 20 private client-owned Chihuahuas. The conclusion was that the polarity of the T-wave is usually negative and the shape is asymmetric, type “slow-fast/down-up”, in all dogs studied.
Acidente vascular cerebral: Explorando a fisiopatologia e distúrbios do sono
Authors: Paula Rafael Monteiro de , Hourani Humberto Cavalcante , Trivelli Gil Guimarães Barbosa , Karajah Omar , Nunes Neto Geraldo Santana Xavier , Aires Melissa Martins Gontijo
Published: October 2023

O acidente vascular cerebral (AVC) caracteriza-se por um déficit neurológico focal decorrente de danos cerebrais de natureza isquêmica ou hemorrágica. O objetivo deste trabalho é abordar a fisiopatologia da doença, descrevendo manifestações clínicas em pacientes com histórico prévio de acidente vascular cerebral, além de estabelecer uma correlação com distúrbios do sono. O presente estudo trata-se de uma revisão narrativa da literatura, de caráter descritivo, pela qual estabeleceu-se que os principais fatores de risco para o desenvolvimento da doença são: hipertensão, tabagismo, alcoolismo e fibrilação atrial. O acometimento mais comum é do tipo isquêmico, representando 80% dos casos, ocorrendo principalmente em pacientes adultos e idosos, apresentando maior incidência após os 65 anos, dobrando a cada década após os 55 anos de idade. O diagnóstico é clínico, com achados de dormência de face e membros, confusão mental, desequilíbrio e alterações de marcha. Já o tratamento se dá por trombólise e trombectomia, ambos guiados por neuroimagem. Somado a isso, percebe-se uma relação íntima entre a doença e os distúrbios do sono, incluindo parassonias, insônia e hipersonia. Além disso, distúrbios do sono pós-AVC afetam reabilitação e qualidade de vida, aumentando a taxa de recorrência dessa patologia.
A flexibilidade dos anéis macrocíclicos e as diferentes conformações espaciais de compostos macrocíclicos metalados e não-metalados
Authors: Moreira Leonardo Marmo , Teixeira Alexandre de Oliveira , Lyon Juliana Pereira
Published: October 2023

A Química dos compostos macrocíclicos é uma das áreas com maiores implicações em diversas áreas multi- e interdisciplinares, tais como química biológica, química de materiais, química dos complexos metálicos e a chamada “química supramolecular”. De fato, tanto na forma complexada como na forma não-complexada, tais compostos são altamente relevantes. Em se tratando dos chamados complexos macrocíclicos, o conhecido “efeito macrocíclico” é a maneira pela qual é mencionada as extraordinárias estabilidades cinética e termodinâmica de tais compostos. Ademais, os compostos de coordenação macrocíclicos muitas vezes são formados, juntamente com a concomitante formação do macrociclo propriamente considerado, ou seja, os precursores da formação do macrociclo são unidos a partir da ação indutora-organizadora do próprio cátion metálico e/ou centro de coordenação (o que é conhecido como “template effect”). Há diversos tipos de relevantes macrociclos, como, por exemplo, os tetraazamacrociclos, conhecidos por várias importâncias, desde a presença em grupos prostéticos de relevantes metaloproteínas, tais como as porfirinas, entre outros macrociclos, passando por aplicações como fotossensibilizantes em terapia fotodinâmica (TFD). e biosensores. O presente estudo apresenta uma introdução ao respectivo tema, abrangendo uma discussão inicial sobre as diferentes conformações espaciais que os macrociclos livres ou em suas formas metaladas podem apresentar e suas implicações. Este trabalho de revisão de literatura visa contribuir com a discussão focada em tais compostos, considerando que as suas distintas conformações espaciais são decisivas para as respectivas relações estrutura-função, o que nem sempre tem sido considerado nas diferentes linhas de pesquisa que perpassam a química dos macrociclos.
Neurosurgical patients' morbidity and mortality during the COVID-19 pandemic: An integrated review
Authors: Carozo Isadora Vieira , Santos Bruno Fernandes de Oliveira
Published: October 2023

Objective: To assess mortality among neurosurgical patients during the COVID-19 pandemic period. Methods: This study entails an integrative literature review conducted by querying predefined descriptors in databases including Science Direct, PubMed®, and the Biblioteca virtual em saúde. Results: A total of 777 articles were identified. After applying inclusion and exclusion criteria, 14 studies were selected to constitute the foundation of this review. A disparity emerged across studies concerning alterations in mortality rates during the COVID-19 pandemic. While the majority of articles (n = 6) reported an increase in mortality, four studies observed no change in mortality rates when comparing the pandemic period with the pre/post-pandemic period. Regarding the number of neurosurgical procedures, a variable decline was observed across studies, ranging between 11.5% and 43%. The majority of articles documented a rise in postoperative complications during the pandemic. Conclusion: A significant impact of the SARS-CoV-2 pandemic on the surgical context was observed, as there was a notable reduction in the number of surgeries performed, leading to an increase in postoperative complications and potentially the mortality rate.
Pengembangan Microlearning Video dengan Menggunakan Aplikasi Canva pada Materi Sistem Pernapasan
Authors: Bou Maria Fatima , Prayitno Trio Ageng , Hidayati Nuril
Published: October 2023

The process of studying biology at this time needs to integrate science and technology. Based on the preliminary study it was found that teachers experienced problems related to the development of instructional media. Therefore, video microlearning using the Canva application is expected to be an alternative to overcome this problem. The purpose of this study was to find out the form of microlearning video development using the Canva application on the respiratory system material. This research is a type of Research and Development research with the ADDIE development model (Analysis, Design, Development, Implementation, and Evaluation). However, this research only carried out three stages of ADD (Analysis, Design, and Development) due to limited research time. The research instruments were interview guidelines, student analysis questionnaire sheets, material validation sheets, media validation sheets, and student response questionnaires for a limited-scale trial of 12 students and a large-scale of 24 students. The types of research data are quantitative data and qualitative data. Research data were analyzed using the quantitative descriptive. The research results showed that the development of microlearning videos using the Canva application on respiratory system material was declared valid by material experts (75%), very valid by media experts (93.75%), and valid based on the results of limited-scale student response trials (80%). Thus, the development of video microlearning using the Canva application on respiratory system material is feasible for use in biology learning in junior high schools.
Sosialisasi e-Heritage History Arts and Culture dalam Mengenalkan Warisan Sejarah dan Budaya di Kota Malang
Authors: Setiani Puspita Pebri , Rahadian Septa , . Adi , Ella Cindi Griz , Pratama Mohammad Febian , Fikry Muhammad
Published: October 2023

Komunitas Jelajah Jejak Malang adalah sebuah komunitas yang berfokus pada pengenalan dan pemahaman terhadap warisan sejarah dan budaya di Kota Malang. Tantangan yang dihadapi oleh komunitas tersebut dalam mempromosikan wisata sejarah Malang saat ini bisa sangat beragam. Tujuan Pengabdian Masyarakat yang di usulkan yakni untuk mendukung upaya-upaya JJM untuk mengatasi tantangan-tantangan dalam mengenalkan dan memahamkan terhadap warisan sejarah dan budaya di Kota Malang untuk para wisatawan domestic maupun luar baik secara langsung maupun virtual melalui e- heritage history arts and culture. Dalam konteks MBKM (Mata Kuliah Berkehidupan Masyarakat) dan IKU (Indikator Kinerja Utama) yang diterapkan pada perguruan tinggi, kegiatan ini dapat menjadi bagian dari upaya perguruan tinggi dalam meningkatkan kualitas pendidikan dan memperluas pengalaman mahasiswa di luar kelas. Metode dalam pengabdian ini adalah sosialisasi tentang pemanfaatan teknologi informasi dimana komunitas Jelajah Jejak Malang (JJM) dapat memanfaatkan teknologi informasi melalui e- heritage history arts and culture dan media sosial untuk memperkenalkan dan mempromosikan warisan sejarah dan budaya Kota Malang kepada masyarakat yang lebih luas, terutama generasi muda yang lebih akrab dengan teknologi digital. Hasil sosialisasi e- heritage history arts and culture dapat menambah pengetahuan dan pemahaman serta ketrampilan anggota komunitas JJM dalam mempromosikan wisata sejarah Kota Malang.
Pelatihan Pembuatan Media Tanam Tanaman Hidroponik Dengan Menggunakan Barang Bekas Ramah Lingkungan Di Desa Bunut Wetan Kabupaten Malang
Authors: Aini Nahda Nur , Yazidah Nok Izatul , Kartika Era Dewi
Published: October 2023

Potential-based community service (PMBP) is an important activity for the Academic Community as academic functional staff both for developing knowledge and solving problems. This community service aims to provide education and insight to the public about the environment and how to recycle plastic waste as needed. This activity certainly had a change impact on the village. Where the results that can be obtained are that the community can reduce environmental pollution by utilizing plastic waste as a medium for growing hydroponic plants and the community can save money on buying vegetables because they can grow their own in the yard.
Sosialisasi dan Pelatihan Senam Sehat Ceria Bersama Ibu-Ibu PKK dan Lansia di Desa Bulupayung
Authors: Rohmah Lailatus Syahrur , Rachmawati Rachmawati , Cipta Dyah Ayu Sulistyaning
Published: October 2023

Senam kebugaran jasmani merupakan suatu rangkaian gerakan senam yang bertujuan untuk meningkatkan atau mempertahankan kebugaran jasmani. Dalam melakukan senam ini selalu di iringi dengan iringan musik. Kegiatan ini bertujuan untuk memperoleh kesehatan dan kebugaran jasmani. Orang yang bugar berarti orang tersebut memiliki kesehatan yang dinamis. Kesehatan yang dinamis ini dapat menunjang aktivitas fisik ataupun psikis. Sedangkan kebugaran yang dimiliki seseorang dapat memberikan pengaruh yang baik terhadap kinerja seseorang serta dapat memberikan pengaruh yang positif terhadap produktivitas belajar atau bekerja. Kebugaran jasmani merupakan kemampuan tubuh dalam melakukan kegiatan sehari-hari tanpa merasakan Lelah yang berlebihan. Sehingga, seseorang dengan kebugaran jasmani yang baik akan selalu memiliki cukup energi untuk beraktivitas fisik dengan lancar. Melalui kegiatan pengabdian masyarakat berbasis potensi (PMBP) mahasiswa IKIP Budi Utomo mengajak kelompok ibu-ibu PKK dan lansia di desa Bulupayung untuk melakukan kegiatan senam sehat ceria setiap hari Minggu pada pagi hari. Selain bermanfaat bagi Kesehatan, senam ini juga berguna untuk meningkatkan suasana hati (keceriaan), membuat tidur menjadi nyenyak dan dapat mengendalikan berat badan
Penyuluhan Kenakalan Remaja Pada Siswa Mts Islamiyah Sukopuro Jabung Sebagai Bentuk Kepedulian Terhadap Masa Depan Generasi Bangsa
Authors: Habib Ahmad Sifaul , Kurniawan Rubbi
Published: October 2023

Penyuluhan kenakalan remaja pada siswa MTs Islamiyah Sukopuro Jabung Kabupaten Malang bertujuan untuk meningkatkan kualitas hidup siswa yang menginjak usia remaja. Usia remaja merupakan usia yang paling rentan terhadap dampak buruk pergaulan disekitar mereka, diantaranya penyalahgunaan narkotika, hubungan seks di luar nikah, pembulian dan tawuran. Metode pengabdian masyarakat berupa penyuluhan secara langsung ke sekolah target dan bekerja sama dengan beberapa instansi, yaitu Pemerintah Desa jabung, MTs Islamiyah Sukopuro Jabung dan Pusat Kesehatan Masyarakat (PKM) kecamatan Tirtoyudo. Beberapa materi yang disampaikan pada kegiatan penyuluhan adalah macam-macam kenakalan remaja, efek buruk yang akan di rasakan ketika masuk kedalam kenakalan remaja dan cara menghindari kenakalan remaja. Setelah mengikuti kegiatan penyuluhan, siswa MTs Islamiyah Sukopuro Jabung diharapkan mampu menyikapi imbas kemajuan era globalisasi yang membawa dampak buruk bagi mereka yang tidak mampu memilah hal yang baik. Mereka diharapkan mampu mengaplikasikan hasil penyuluhan dalam diri mereka agar menjadi generasi penerus yang berkualitas unggul.
Peningkatan Kreatifitas Anak Santri Melalui Pelatihan Origami
Authors: Arsyad Muhammad Naharuddin , Khoiroh Iftahatul
Published: October 2023

Keterampilan  origami  merupakan  salah  satu bentuk kesenian melipat  kertas yang berasal dari  Jepang.  Melalui  pelatihan  membuat  origami  ini  diharapkan para peserta yaitu santri  dapat meningkatkan imajinasi dan kreativitasnya sebagai pelajar. Pengenalan  origami  dilakukan sebagai kegiatan pengabdian masyarakat berbasis potensi 2022/2023 yang terlaksana pada tanggal 04 Februari 2023 yang bertempat di Desa Jeru Kecamatan Turen Kabupaten Malang. Kegiatan pengabdian yang diberikan berupa pelatihan yang terdiri dari 3 kegiatan. Pertama  adalah  memberikan  materi tentang pengertian,  sejarah, jenis-jenis, dan manfaat origami. Kegiatan kedua adalah pelatihan membuat origami dengan berbagai  bentuk.  Selanjutnya  kegiatan terakhir adalah evaluasi,  yang  bertujuan  untuk  memastikan  apakah  para  peserta dapat menyerap materi dengan baik. Kegiatan  ini  sangat  memberikan  manfaat  bagi  anak  santri dalam hal meningkatkan kemampuan motorik. Origami juga  dapat dijadikan alternatif permainan, dimana permainan keterampilan mulai ditinggalkan akibat keberadaan ponsel dan gawai digital lainnya.
Bimbingan Belajar Mengaji dan Hafalan Al- Qur’an Di SMP Aisyiyah Muhammadiyah 3 Malang
Authors: Yana Yana , Sorraya Artifa , Lutfiyah Luly Zahrotul
Published: October 2023

Tutoring to memorize the Al-Qur'an is carried out so that students can better understand and comprehend the Al-Qur'an, and this is one of the processes of providing assistance to students to be able to better remember and recognize the contents of the Al-Qur'an. along with the tajwid. Habituation is an effective way of instilling positive values ​​into a person, both cognitively, psychomotorically and affectively. Apart from that, habituation is also considered an efficient way of changing negative habits into positive habits. The cognitive effect of learning to recite the Koran is that it affects students' memory, understanding and problem solving. Studying the Qur'an influences the moral condition of students regarding how to behave and behave in a good social life in the future. Moreover, it can provide knowledge about good and bad things as contained in the Qur'an because by understanding and knowing the content in The Qur'an can be applied in everyday life. The targets of the PMBP activities carried out include students of 'Aisyiyah Muhammadiyah 3 Malang Middle School (Tutoring). Tutoring (Reciting the Koran and Memorizing Short Surahs) at SMP 'Aisyiyah Muhammadiyah 3 Malang from 2 February 2022 to 24 February 2022 and activities are held from Monday to Thursday. The Koran study guidance and short letter memorization activities for Aisyiyah Muhammadiyah 3 Malang Middle School students went according to what had been planned. This activity also ran smoothly. Guidance for studying the Koran and memorizing short surahs for students at SMP Aisyiyah Muhammadiyah 3 Malang went smoothly because the students were very active and very enthusiastic about learning.
Upaya Peningkatan Asesmen Kompetensi Minimum (AKM) melalui Progam Literasi dan Numerasi Kampus Mengajar 5 di UPT Satuan Pendidikan SDN Pusungmalang II Puspo
Authors: Iza Nikmatul , Nisa Khoirun , Arifin As’ad Syamsul , Alawiyah Mufidatul , Sari Karisma Juwita , Salsabila Irine Balgis
Published: October 2023

The teaching campus program is one of the government's programs in order to realize the Independent Learning-Free Campus (MBKM) activities. Campus teaching programs are generally intended to improve literacy, numeracy, technological adaptation, and school administration. The aim of this service is how to improve the minimum competency assessment (AKM) through the literacy and numeracy program at teaching campus 5 at the UPT Education Unit of SDN Pusungmalang II Puspo. This type of qualitative descriptive research involves conducting observations and interviews, AKM pretest, followed by literacy and numeracy activities, and AKM posttest. The results of the AKM pretest assessment, the average score that students got in literacy was 53.65 and the AKM posttest increased to 77.880, while the AKM pretest assessment in numeracy the average score that students got was 39.03 and the AKM posttest the average score that students got increased to 71.15.
Penyuluhan Tentang Kebersihan Lingkungan Warga Masyarakat dalam Gotong Royong Pembersihan Lingkungan di Area Kantor Desa Ana Goka
Authors: Kondo Martina , Novariyanto Rizki Agung
Published: October 2023

Kegiatan Pmbp ini berfokus pada peran mahasiswa PPL dalam melaksanakan kegiatan gotong royong. Peran mahasiswa PPL ini dalam melaksanakan kegiatan gotong royong sangat memungkinkan dan mengingat apa yang menjadi kewenangannya, tentunya dapat membangun kesadaran masyarakat desa. Oleh karena itu perlu suatu strategi maupun kebijakan agar dalam pelaksanaanya dapat berjalan dengan baik. Kegiatan PMBP ini bertujuan untuk mendeskripsikan serta peran masyarakat dalam melaksanakan kegiatan gotong royong  di Desa Anagouka. Informan penelitian ini adalah kepala desa, Aparat desa, dan warga masyarakat di Desa Anagouka. Teknik pengumpulan data pada penelitian ini adalah observasi, gotong royong, dan dokumentasi. Hasil yang di dapatkan dalam penelitian ini menunjukkan beberapa hal pertama, melalui kegiatan gotong royong bersama aparat desa  dan masyarakat desa mali iha, kepedulian masyarakat terhadap mahasiswa ppl dalam membantu melaksanakan kegiatan pmbp, aparatur desa sebagai motivator  telah bekerjasama dalam hal ini bersama-sama meningkatkan pembangunan desa dengan pelaksanaan gotong royong, peran aparatur desa sebagai fasilitator cukup membantu masyarakat desa Ana goka, yang menyatakan bahwa kepala desa sangat membantu dalam memecahkan masalah pembangunan desa.
Percutaneous Cholecystostomy is a Feasible and Safe Option for High-Risk Acute Cholecystitis Patients
Authors: AYDINER Ömer , RAŞA Hüseyin Kemal
Published: October 2023

Objective: The best option for treating high-risk patients with acute cholecystitis is still being determined. We evaluated our high-risk acute cholecystitis patients in whom we preferred percutaneous cholecystostomy and aimed to determine whether this approach was safe and feasible.

Methods: We retrospectively reviewed our 71 patients in whom we performed percutaneous cholecystostomy between May 2019 and July 2023. All procedures were performed with local anaesthesia under ultrasonographic guidance via the transhepatic route. The catheters were removed when the signs of acute cholecystitis were significantly regressed or when the catheters were found to be ineffective. The catheters of those eligible for surgery were removed during the operations.

Results: All procedures were successful without failure, and no significant complications developed in the post-intervention period. Pain at the catheter insertion site (20 patients) was the leading minor complication, and in one patient, bilioma was detected and percutaneously drained. The procedure was ineffective in 7 patients (9.85%), and the catheters were removed. In 22 patients (31%), interval cholecystectomy surgery was performed. In the subgroup of patients whose catheters were adequate and were not operated (5 patients), the catheters were removed after an average of 27.2 days. The mean length of stay was 9.6 days, and four patients died (5.6%) during the index hospitalization.

Conclusion: Our findings suggest that percutaneous cholecystostomy is a feasible, safe and highly effective treatment option for acute cholecystitis in high-risk patients.
IMPLEMENTASI KEAMANAN JARINGAN MENGGUNAKAN PORT KNOCKING
Authors: Mendrofa Yuniaman , Fauzi Rahmat
Published: October 2023

Technological advancements continue to progress rapidly, allowing experts to enhance their knowledge across various industries, including health, network security, and others. PT Air Batam Hulu is a water company situated at Building A-WTP Moya Muka Kuning Jl. Letjend Supranto in Batam, responsible for managing the security of drinking water. However, the company's existing system is susceptible to data security breaches due to unauthorized hacking attempts. In addition, computer network systems face both physical and logical threats, such as Sniffer, Spoofing, Preaking, Remote Attack, Hole, Hacker, Cracker, and more. Among the current successful hacking attempts, UML sites, Malware, Trojans, Viruses, and port scanning are commonly encountered. To address security concerns, the company implements a security system called "port knocking," which involves opening or closing access to specific ports through the use of a firewall on network devices. This system works by sending certain packets or connections, including TCP, UDP, and ICMP protocols. To gain access to restricted ports, users are required to perform a "knocking" action by inputting the necessary rule beforehand. This ensures that only authorized users can access and use specific ports, enhancing data security and reducing the risk of unauthorized infiltration.
ANALISIS PENGENDALIAN KUALITAS PRINTING HOUSING TOP MELITA PADA PT LEON TEKNOLOGI GLOBAL
Authors: Laia Saferia Suiman , Asmarawati Citra Indah
Published: October 2023

PT Leon Teknologi is a company engaged in the coating or polishing of raw materials for parts and even assy such as spray painting which has several large customers in the city of Batam, HSG TOP Melitta is a customer in the field of spray painting who has just collaborated with PT Leon in 2020 In terms of quality control issues at PT Leon, visual reject is the main contribution, with a reject rate of 3.5% of the total quantity during the last 6 months of production in the spray painting process, such as Crack on, scratch, White/Black dot and Over painting on Housing Top melitta after printing, Factors Causing Defects on Fishbone analysis, namely from scratch From Human Factors, scratch defects are caused by a lack of production operator training which causes inaccurate operator handling and a lack of understanding of the types of product defects that occur in the production process and methods, namely The lack of clarity on work instructions for the spray painting process caused the spray painting process to be inconsistent with operator procedures and finally the material, which is a type of material that is easily scratched, needs to be reviewed for work instructions on the Melitta upper housing. The Crack factor from Crack is likely to occur in mixing paint with thinner which has a ratio of 1 (Paint): 3 (Thinner) and in general some Spray Painting uses a ratio of 1 (Paint) : 1.3 (Thinner) and some experiments use a ratio of paint and thinner the latest so that out of 30 samples no Crack was Found
PERANCANGAN APLIKASI RESEP MASAKAN TRADISIONAL INDONESIA MENGGUNAKAN PENDEKATAN AGILE PROCESS DENGAN MODEL EXTREME PROGRAMMING BERBASIS ANDROID
Authors: Sitompul Elisawiah , Hutabri Elbert
Published: October 2023

Almost all aspects of human life have now been touched by tehnological advances, one of which is food recipes. In the past, when you wanted to learn food recipes, you had to go through magazines and newspaper. Then was a change, food recipes can be found on the website in the form of the text and images. Then it developed in to video broadcast on youtube, which can access via a computer or smartphone. This development in the culinery field is indeed very helpful, but it still has weaknees namely, the information contained on the websites and videos is only for one type of food, if you want to find another dish you have to search again, this method also requires quite a lot of time to find food recipes according to your wants and needs, and the food recipes you are looking for are easily lost and easily forgotten because they cannot be stored permanently. So that with the application Android-based tradisional Indonesian food recipes, it can be accsessed mobile by using a smartphone.So this is quite helpful for users to make it easier to find information about the materials needed to how make to make them. The approach used is an agile process approach with an extreme programming model, then the design uses UML (Unified Modeling Language).
Keywords: Food Recipes, Android, Agile Process, Extreme Programming
Left atrium 4D-flow segmentation with high-resolution contrast-enhanced magnetic resonance angiography
Authors: Kim Hansuk , Wilton Stephen B. , Garcia Julio
Published: October 2023

Background

Atrial fibrillation (AF) leads to intracardiac thrombus and an associated risk of stroke. Phase-contrast cardiovascular magnetic resonance (CMR) with flow-encoding in all three spatial directions (4D-flow) provides a time-resolved 3D volume image with 3D blood velocity, which brings individual hemodynamic information affecting thrombus formation. As the resolution and contrast of 4D-flow are limited, we proposed a semi-automated 4D-flow segmentation method for the left atrium (LA) using a standard-of-care contrast-enhanced magnetic resonance angiography (CE-MRA) and registration technique.

Methods

LA of 54 patients with AF were segmented from 4D-flow taken in sinus rhythm using two segmentation methods. (1) Phase-contrast magnetic resonance angiography (PC-MRA) was calculated from 4D-flow, and LA was segmented slice-by-slice manually. (2) LA and other structures were segmented from CE-MRA and transformed into 4D-flow coordinates by registration with the mutual information method. Overlap of volume was tested by the Dice similarity coefficient (DSC) and the average symmetric surface distance (ASSD). Mean velocity and stasis were calculated to compare the functional property of LA from two segmentation methods.

Results

LA volumes from segmentation on CE-MRA were strongly correlated with PC-MRA volume, although mean CE-MRA volumes were about 10% larger. The proposed registration scheme resulted in visually successful registration in 76% of cases after two rounds of registration. The mean of DSC of the registered cases was 0.770 ± 0.045, and the mean of ASSD was 2.704 mm ± 0.668 mm. Mean velocity had no significant difference between the two segmentation methods, and mean stasis had a 3.3% difference.

Conclusion

The proposed CE-MRA segmentation and registration method can generate segmentation for 4D-flow images. This method will facilitate 4D-flow analysis for AF patients by making segmentation easier and overcoming the limit of resolution.
Comparison of pulmonary vein isolation using cryoballoon, high-power short-duration, and conventional radiofrequency ablation for atrial fibrillation: a propensity score-weighted study
Authors: Park Hanjin , Park Je-Wook , Kim Daehoon , Yu Hee Tae , Kim Tae-Hoon , Uhm Jae-Sun , Joung Boyoung , Lee Moon-Hyoung , Hwang Chun , Pak Hui-Nam
Published: October 2023

Background

The comparative efficacy, saftey, and heart rate variability (HRV) parameters after pulmonary vein isolation using cryoballoon (Cryo-PVI), high-power short-duration (HPSD-PVI), and conventional radiofrequency ablation (conventional-PVI) for atrial fibrillation (AF) is unclear.

Materials and methods

In this propensity score-weighted, retrospective analysis of a single-center cohort, we analyzed 3,395 patients (26.2% female, 74.5% paroxysmal AF) who underwent AF catheter ablation without an empirical left atrial ablation. Procedural factors, recurrence rates, complication rates, and the post-procedural HRV parameters were compared across the Cryo-PVI (n = 625), HPSD-PVI (n = 748), and conventional-PVI (n = 2,022) groups.

Results

Despite the shortest procedural time in the Cryo-PVI group (74 min for Cryo-PVI vs. 104 min for HPSD-PVI vs. 153 min for conventional-PVI, p < 0.001), the major complication (p = 0.906) and clinical recurrence rates were similar across the three ablation groups (weighted log-rank, p = 0.824). However, the Cryo-PVI group was associated with a significantly lower risk of recurrent AF in patients with paroxysmal AF [weighted hazard ratio (WHR) 0.57, 95% confidence interval (CI) 0.37–0.86], whereas it was associated with a higher risk of recurrent AF in patients with persistent AF (WHR 1.41, 95% CI 1.06–1.89, p for interaction of <0.001) compared with the conventional-PVI group. In the subgroup analysis for the HRV, the Cryo-PVI group had the highest low-frequency-to-high-frequency ratio at 1-year post-procedure, whereas the HPSD-PVI group had the lowest low-frequency-to-high-frequency ratio at 1-year post-procedure (p < 0.001).

Conclusions

The Cryo-PVI group had better rhythm outcomes in patients with paroxysmal AF but worse rhythm outcomes in patients with persistent AF and a higher long-term post-procedural sympathetic nervous activity and sympatho-vagal balance compared with the conventional-PVI group.
Leaflet thrombosis in transcatheter aortic valve intervention: mechanisms, prevention, and treatment options
Authors: Koren Ofir , Patel Vivek , Chakravarty Tarun , Jilaihawi Hasan , Gupta Aakriti , Sadri Shirin , Makkar Raj R.
Published: October 2023

Introduction

Transcatheter aortic valve intervention (TAVR) has emerged as a promising alternative to surgical aortic valve replacement for patients with severe aortic stenosis. However, leaflet thrombosis has raised concerns about the long-term durability and outcomes of TAVR. This study aims to provide an overview of the mechanisms, prevention strategies, and treatment options for leaflet thrombosis in TAVR.

Clinical evidence

Leaflet thrombosis refers to the formation of blood clots on bioprosthetic valve leaflets, leading to impaired leaflet mobility, early valve degeneration and dysfunction, and potential clinical implications. While the mechanisms underlying thrombus formation on valve leaflets are not fully understood, several factors, such as altered blood flow patterns within valve neosinuses, prothrombotic surfaces, and patient-related causes, have been implicated. Two distinct entities have been identified, namely, hypoattenuated leaflet thickening and restricted leaflet motion. Their occurrence appears dynamic over time and is related to the valve type. Imaging, including transesophageal echocardiography and multidetector computed tomography, plays a crucial role in the diagnosis and follow-up of leaflet thrombosis.

Prevention and treatment options

Preventing leaflet thrombosis requires a comprehensive and tailored approach involving identifying high-risk patients, close monitoring, and antithrombotic therapy. Antithrombotic therapy with dual antiplatelet agents or anticoagulation is commonly employed in TAVR patients, although the optimal regimen is yet to be defined. Novel antithrombotic agents, such as direct oral anticoagulants, are being investigated for their efficacy and safety in preventing leaflet thrombosis. When leaflet thrombosis is detected, treatment options include intensified antithrombotic therapy, valve-in-valve intervention, or balloon valvuloplasty. The long-term outcomes and impact of leaflet thrombosis on valve durability and patient prognosis are areas of ongoing research.

Leaflet thrombosis in TAVR is a considerable complication affecting valve function and patient outcomes. Understanding the mechanisms underlying thrombus formation and implementing appropriate prevention strategies are essential for mitigating this risk. Treatment options aim to restore leaflet mobility and optimize valve performance. Further research is needed to establish standardized protocols for antithrombotic therapy, identify high-risk patient populations, and determine the long-term consequences of leaflet thrombosis on TAVR outcomes.
A data-driven framework for clinical decision support applied to pneumonia management
Authors: Free Robert C. , Lozano Rojas Daniel , Richardson Matthew , Skeemer Julie , Small Leanne , Haldar Pranabashis , Woltmann Gerrit
Published: October 2023

Despite their long history, it can still be difficult to embed clinical decision support into existing health information systems, particularly if they utilise machine learning and artificial intelligence models. Moreover, when such tools are made available to healthcare workers, it is important that the users can understand and visualise the reasons for the decision support predictions. Plausibility can be hard to achieve for complex pathways and models and perceived “black-box” functionality often leads to a lack of trust. Here, we describe and evaluate a data-driven framework which moderates some of these issues and demonstrate its applicability to the in-hospital management of community acquired pneumonia, an acute respiratory disease which is a leading cause of in-hospital mortality world-wide. We use the framework to develop and test a clinical decision support tool based on local guideline aligned management of the disease and show how it could be used to effectively prioritise patients using retrospective analysis. Furthermore, we show how this tool can be embedded into a prototype clinical system for disease management by integrating metrics and visualisations. This will assist decision makers to examine complex patient journeys, risk scores and predictions from embedded machine learning and artificial intelligence models. Our results show the potential of this approach for developing, testing and evaluating workflow based clinical decision support tools which include complex models and embedding them into clinical systems.
Effects of adaptations of a phonics-based reading intervention program on reading and spelling skills of students with intellectual disability who require augmentative and alternative communication
Authors: Linder Anne-Laure , Geyer Megan , Atzemian Myrto , Meuli Natalina , Martinet Catherine , de Chambrier Anne-Françoise , Dessemontet Rachel Sermier
Published: October 2023

Introduction

This study is an examination of the effects of a series of adaptations made to a phonics-based reading intervention program for students with an intellectual disability (ID). The adaptations were designed to make the program more accessible to augmentative and alternative communication (AAC) users. They consisted of using a pointing-response modality to allow participants to give their answers as well as the use of internal speech, which involved performing certain tasks in one’s head because students with complex communication needs could not perform them aloud. Participants also completed reading and spelling activities on an iPad® application.

Methods

A multiple-probe-across-participants design was used. Specifically, the adapted reading program’s effects were assessed on reading and spelling skills of three students with ID who were AAC users.

Results

The outcomes indicate that all three participants improved their reading skills, and two participants also improved their spelling skills.

Discussion

The results and implications for future research are discussed.
“No research on a dead planet”: preserving the socio-ecological conditions for academia
Authors: Thierry Aaron , Horn Laura , von Hellermann Pauline , Gardner Charlie J.
Published: October 2023

Despite thousands of higher education institutions (HEIs) having issued Climate Emergency declarations, most academics continue to operate according to ‘business-as-usual’. However, such passivity increases the risk of climate impacts so severe as to threaten the persistence of organized society, and thus HEIs themselves. This paper explores why a maladaptive cognitive-practice gap persists and asks what steps could be taken by members of HEIs to activate the academy. Drawing on insights from climate psychology and sociology, we argue that a process of ‘socially organized denial’ currently exists within universities, leading academics to experience a state of ‘double reality’ that inhibits feelings of accountability and agency, and this is self-reenforcing through the production of ‘pluralistic ignorance.’ We further argue that these processes serve to uphold the cultural hegemony of ‘business-as-usual’ and that this is worsened by the increasing neo-liberalization of modern universities. Escaping these dynamics will require deliberate efforts to break taboos, through frank conversations about what responding to a climate emergency means for universities’ – and individual academics’ – core values and goals.
Simultaneous extraction and detection of peptides, steroids, and proteins in small tissue samples
Authors: Lu Chunyu , Peng Di , Erandani W. C. K. Udeesha , Mitchell Kimberly , Martyniuk Christopher J. , Trudeau Vance L.
Published: October 2023

The detection and quantification of hormones are important to assess the reproductive and stress status of experimental models and for the diagnosis of diseases in human and veterinary clinics. Traditionally, steroid, peptide, and protein hormones are analyzed in individual experiments using different extraction methodologies. With the new advancement on HPLC sorbents, the simultaneous measurement of hormones from different categories becomes possible. In this study, we present a novel sample processing strategy for the simultaneous extraction and detection of peptides, steroids, and proteins using high-resolution liquid chromatography tandem mass spectrometry. We demonstrate the sensitivity of our method for small tissues by acquiring data from brain, pituitary gland, and gonads of single zebrafish samples. This approach promises to shed light on the hormonal pathways and their interrelationships, providing knowledge on the integration of hormone systems.
Exploring blood metabolites and thyroid disorders: a bidirectional mendelian randomization study
Authors: Zhang Xuan , Zhou Jiating , Xie Zilan , Li Xi , Hu Jiaqing , He Hengzheng , Li Zhi
Published: October 2023

Background

Human blood metabolites have demonstrated close associations with thyroid disorders in observational studies. However, it’s essential to determine whether these correlations imply causation. Mendelian Randomization (MR) offers a promising approach to investigate these patterns.

Aims

The primary aim of our investigation is to establish causality between blood metabolites and three thyroid disorders: TC, GD, and HT.

Methods

We employed a two-sample bidirectional MR analysis approach to assess the relationships between 452 blood metabolites and the three aforementioned thyroid disorders. Causal links were estimated using the IVW method, with sensitivity analyses conducted via MR-Egger, Weighted Median, and MR-PRESSO. We assessed potential heterogeneity and pleiotropy using MR-Egger intercept and Cochran’s Q statistic. Additionally, we conducted pathway analysis to identify potential metabolic pathways.

Results

We found 46 metabolites that showed suggestive associations with thyroid disease risk, especially Aspartate (ORIVW=7.41; 95%CI: 1.51-36.27; PIVW=0.013) and C-glycosyltryptophan (ORIVW=0.04; 95%CI: 0.00–0.29; PIVW=0.001) impacted TC, Kynurenine (ORIVW=2.69; 95%CI: 1.08–6.66; PIVW=0.032) and 4-androsten-3beta,17beta-diol disulfate 2 (ORIVW=0.78; 95%CI: 0.48–0.91; PIVW=0.024) significantly impacted GD, and Alpha-ketoglutarate (ORIVW=46.89; 95%CI: 4.65–473.28; PIVW=0.001) and X-14189–leucylalanine (ORIVW=0.31; 95%CI: 0.15–0.64 PIVW=0.001) significantly impacted HT. We also detected 23 metabolites influenced by TC and GD. Multiple metabolic pathways have been found to be involved in thyroid disease.

Conclusion

Our MR findings suggest that the identified metabolites and pathways can serve as biomarkers for clinical thyroid disorder screening and prevention, while also providing new insights for future mechanistic exploration and drug target selection.
Association between adipocytokines and diabetic retinopathy: a systematic review and meta-analysis
Authors: Jiang Yanhua , Fan Huaying , Xie Jing , Xu Yao , Sun Xin
Published: October 2023

Background

Diabetic retinopathy (DR) is a common complication of diabetes. The adipocytokines are closely associated with the occurrence and development of diabetes and its related complications. Literature confirms that the level of adiponectin in patients with DR is significantly higher; however, the relationship between other adipocytokines (leptin, chemerin, apelin, and omentin-1) and DR remains unclear.

Aim

This study aimed to systematically evaluate the association between adipocytokines (leptin, chemerin, apelin, and omentin-1) and DR.

Methods

The PubMed, Web of Science, Embase, EBSCO and Willy databases were used to search for potential studies with keywords such as “diabetic retinopathy” or “DR” in combination with the terms “leptin,” “chemerin”, “apelin” or “omentin-1” in the search titles or abstracts. Standardized mean differences (SMD) with corresponding 95% confidence intervals (CIs) were determined as the results of the meta-analysis.

Results

After screening, 18 articles were included in the meta-analysis including 750 DR cases and 993 controls. Leptin and chemerin levels in patients with DR were significantly higher than those in the control group (SMD: 0.68, 95% CI [0.1, 1.26]; SMD: 0.79, 95% CI [0.35, 1.23]). The omentin-1 levels in patients with DR were significantly lower than those in the controls (SMD: –0.85, 95% CI [–1.08, –0.62]).

Conclusions

To the best of our knowledge, this is the first meta-analysis to evaluate the leptin, chemerin, apelin, and omentin-1 levels in patients with DR. Further high-quality studies are warranted to support the association between these adipocytokines and DR.

Systematic review registration

https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=443770, identifier CRD42023443770.