bluuebunny/crossref_metadata_2025 huggingface dataset:
Post-COVID-19 Syndrome Comprehensive Assessment: From Clinical Diagnosis to Imaging and Biochemical-Guided Diagnosis and Management
Authors: Yan Michael Zhipeng , Yang Ming , Lai Ching-Lung
Published: February 2023

The COVID-19 outbreak was first reported in 2019, causing massive morbidity and mortality. The majority of the COVID-19 patients survived and developed Post-COVID-19 Syndrome (PC19S) of varying severity. Currently, the diagnosis of PC19S is achieved through history and symptomatology that cannot be explained by an alternative diagnosis. However, the heavy reliance on subjective reporting is prone to reporting errors. Besides, there is no unified diagnostic assessment tool to classify the clinical severity of patients. This leads to significant difficulties when managing patients in terms of public resource utilization, clinical progression monitorization and rehabilitation plan formulation. This narrative review aims to review current evidence of diagnosis based on triple assessment: clinical symptomatology, biochemical analysis and imaging evidence. Further assessment tools can be developed based on triple assessment to monitor patient’s clinical progression, prognosis and intervals of monitoring. It also highlights the high-risk features of patients for closer and earlier monitoring. Rehabilitation programs and related clinical trials are evaluated; however, most of them focus on cardiorespiratory fitness and psychiatric presentations such as anxiety and depression. Further research is required to establish an objective and comprehensive assessment tool to facilitate clinical management and rehabilitation plans.
Risk Factors for Influenza-Induced Exacerbations and Mortality in Non-Cystic Fibrosis Bronchiectasis
Authors: Huang Hung-Yu , Lo Chun-Yu , Chung Fu-Tsai , Huang Yu-Tung , Ko Po-Chuan , Lin Chang-Wei , Huang Yu-Chen , Chung Kian Fan , Wang Chun-Hua
Published: February 2023

Influenza infection is a cause of exacerbations in patients with chronic pulmonary diseases. The aim of this study was to investigate the clinical outcomes and identify risk factors associated with hospitalization and mortality following influenza infection in adult patients with bronchiectasis. Using the Chang Gung Research Database, we identified patients with bronchiectasis and influenza-related infection (ICD-9-CM 487 and anti-viral medicine) between 2008 and 2017. The main outcomes were influenza-related hospitalization and in-hospital mortality rate. Eight hundred sixty-five patients with bronchiectasis and influenza infection were identified. Five hundred thirty-six (62%) patients with bronchiectasis were hospitalized for influenza-related infection and 118 (22%) patients had respiratory failure. Compared to the group only seen in clinic, the hospitalization group was older, with more male patients, a lower FEV1, higher bronchiectasis aetiology comorbidity index (BACI), and more acute exacerbations in the previous year. Co-infections were evident in 55.6% of hospitalized patients, mainly caused by Pseudomonas aeruginosa (15%), fungus (7%), and Klebsiella pneumoniae (6%). The respiratory failure group developed acute kidney injury (36% vs. 16%; p < 0.001), and shock (47% vs. 6%; p < 0.001) more often than influenza patients without respiratory failure. The overall mortality rate was 10.8% and the respiratory failure group exhibited significantly higher in-hospital mortality rates (27.1% vs. 6.2%; p < 0.001). Age, BACI, and previous exacerbations were independently associated with influenza-related hospitalization. Age, presence of shock, and low platelet counts were associated with increased hospital mortality. Influenza virus caused severe exacerbation in bronchiectasis, especially in those who were older and who had high BACI scores and previous exacerbations. A high risk of respiratory failure and mortality were observed in influenza-related hospitalization in bronchiectasis. We highlight the importance of preventing or treating influenza infection in bronchiectasis.
Self-Reported Allergic Adverse Events Following Inactivated SARS-CoV-2 Vaccine (TURKOVAC™) among General and High-Risk Population
Authors: Kara Ateş , Coskun Aslihan , Temel Fehminaz , Özelci Pervin , Topal Selmur , Ates İhsan
Published: February 2023

TURKOVAC™ is a whole-virion inactivated COVID-19 vaccine which was developed and granted emergency use and conditional marketing authorization in December 2021 in Türkiye. The objective of this study is to assess the distribution and the severity of allergic adverse events following the administration of the vaccine as the primary or the booster dose in 15 provinces in Türkiye. In this cohort study, between February and May 2022, in the selected 15 provinces having an adequate number of health care personnel in the community health centers to conduct the study, 32,300 people having the first, the second, or the booster dose of the vaccine were invited to the survey. A total of 29,584 people voluntarily agreed to participate to the survey and were given a structured questionnaire after a minimum of 10 days following the vaccination. In our study, only 0.5% of the participants (142 persons) reported to experience any allergic reaction, and 12 of them (8.5%) reported to be given medical treatment in a health center. Male predominance (55.6%) was observed among participants reported to experience any allergic reaction. No hospitalization was recorded. Of the participants, 4.4% (1315 people) reported to have a history of allergy. The most reported allergens were drugs. Among the participants without a known history of allergy (n = 28,269), 0.4% of them (110 people) reported to experience an allergic reaction following the vaccination, and 5.4% of the allergic reactions (six people) were reported to be treated in a health center. The percentage of the participants given any medical treatment among the participants without a known history of allergy is 0.02%. No immediate or anaphylactic reaction was reported. Among the participants with a known history of allergy (n = 1315), 32 people (2.4% of them) reported to experience an allergic reaction following the vaccination, and 18.7% of the allergic reactions (six people) were reported to be prescribed a medical treatment. The percentage of the participants given any medical treatment among the participants with a known history of allergy is 0.4%. A known history of allergy increased the risk of having an allergic experience by approximately six times following vaccination. As a whole-virion inactivated SARS-CoV-2 vaccine, the TURKOVAC™ vaccine, with a low allergic reaction-related adverse event profile, can be an alternative to other COVID-19 vaccines.
Usefulness and Limitations of Cryopreservation for Immunocytochemical Staining of Canine Cytological Specimens for Detection of Cytokeratin and Vimentin
Authors: Furusawa Yu , Shima-Sawa Mariko , Hifumi Tatsuro , Miyoshi Noriaki , Yamato Osamu , Yabuki Akira
Published: February 2023

Immunocytochemistry is an advanced diagnostic tool for identifying the origin of tumor cells. This study aimed to highlight the usefulness of cryopreserved, air-dried cytological samples in detecting cytokeratin and vimentin. Air-dried cytological smear samples were prepared from a total of 39 resected canine tumors and stored in a medical freezer without fixation. The duration of cryopreservation ranged from 2 to 56 months. The same tumors were processed for routine histopathological examination. Based on the morphological diagnosis, cryopreserved FNA smears from epithelial tumors were stained by enzymatic immunocytochemistry (ICC) for cytokeratin; those from mesenchymal and melanocytic tumors were stained by ICC for vimentin. To ascertain the positivity of tumor cells to the selected markers, tissue paraffin-embedded sections were also stained by immunohistochemistry (IHC) for the same markers. Immunoreactivity for cytokeratin was detected in cryopreserved cytological smears for a maximum of 46 months. Immunoreactivity for vimentin was clearly detected for 33 months. Smears stored at room temperature for 1 week did not show any signals under immunocytochemical examination. Thus, immunocytochemistry for cytokeratin and vimentin can be safely applied to air-dried smears cryopreserved in a freezer for at least 33 months.
The Status and Risk Factors of Brucellosis in Smallholder Dairy Cattle in Selected Regions of Tanzania
Authors: Mengele Isaac Joseph , Shirima Gabriel Mkilema , Bwatota Shedrack Festo , Motto Shabani Kiyabo , Bronsvoort Barend Mark de Clare , Komwihangilo Daniel Mushumbusi , Lyatuu Eliamoni , Cook Elizabeth Anne Jessie , Hernandez-Castro Luis E.
Published: February 2023

Bovine brucellosis is a bacterial zoonoses caused by Brucella abortus. We conducted a cross-sectional study to determine brucellosis seroprevalence and risk factors among smallholder dairy cattle across six regions in Tanzania. We sampled 2048 dairy cattle on 1374 farms between July 2019 and October 2020. Sera were tested for the presence of anti-Brucella antibodies using a competitive enzyme-linked immunosorbent assay. Seroprevalence was calculated at different administrative scales, and spatial tests were used to detect disease hotspots. A generalized mixed-effects regression model was built to explore the relationships among Brucella serostatus, animals, and farm management factors. Seroprevalence was 2.39% (49/2048 cattle, 95% CI 1.7–3.1) across the study area and the Njombe Region represented the highest percentage with 15.5% (95% CI 11.0–22.0). Moreover, hotspots were detected in the Njombe and Kilimanjaro Regions. Mixed-effects models showed that having goats (OR 3.02, 95% C 1.22–7.46) and abortion history (OR 4.91, 95% CI 1.43–16.9) were significant risk factors for brucellosis. Education of dairy farmers regarding the clinical signs, transmission routes, and control measures for brucellosis is advised. A One Health approach is required to study the role of small ruminants in cattle brucellosis and the status of brucellosis in dairy farmers in the Njombe and Kilimanjaro Regions.
Thiamine Supplementation Improves Survival and Body Condition of Hatchery-Reared Steelhead (Oncorhynchus mykiss) in Oregon
Authors: Reed Aimee N. , Rowland Freya E. , Krajcik Jennifer A. , Tillitt Donald E.
Published: February 2023

Early rearing of steelhead (Oncorhynchus mykiss) in Oregon hatcheries is often problematic; fry can become emaciated and die during the period between hatch and first feed. Thiamine (vitamin B1) deficiency has caused early mortality in salmonids; however, the thiamine status of Oregon’s steelhead populations is unknown, to date. Of the 26 egg samples from three Oregon hatcheries in 2019, 20 (77%) had thiamine levels < 10 nmol/g, and 13 of those samples (50%) had levels <6.5 nmol/g, suggesting the thiamine deficiency of adult, female steelhead. To investigate if thiamine deficiency was causally related to fry survival, females were injected with buffered thiamine HCl 50 mg/kg prior to spawning; additionally, a subset of eggs were supplemented via bath treatment with thiamine mononitrate (1000 ppm) at spawning. Cumulative fry mortality at 8 weeks post-hatch from thiamine-injected females was 2.9% compared to 13.8% mortality of fry without thiamine supplementation. Fry treated only with the thiamine via bath as eggs had a mortality rate of 6.9%. There were no additional improvements for the survival of fry from injected females that also received a thiamine bath. Furthermore, condition factors were greater in thiamine-supplemented fry than in those that received no thiamine. These data identify thiamine deficiency in Oregon steelhead and suggest supplementation with thiamine can mitigate early rearing mortality.
The Action Cycle Theory of Perception and Mental Imagery
Authors: Marks David F.
Published: February 2023

The Action Cycle Theory (ACT) is an enactive theory of the perception and a mental imagery system that is comprised of six modules: Schemata, Objects, Actions, Affect, Goals and Others’ Behavior. The evidence supporting these six connected modules is reviewed in light of research on mental imagery vividness. The six modules and their interconnections receive empirical support from a wide range of studies. All six modules of perception and mental imagery are influenced by individual differences in vividness. Real-world applications of ACT show interesting potential to improve human wellbeing in both healthy people and patients. Mental imagery can be applied in creative ways to make new collective goals and actions for change that are necessary to maximize the future prospects of the planet.
Quantification of Intra- vs. Inter-Row Leaching of Major Plant Nutrients in Sloping Vineyard Soils
Authors: Filipović Lana , Krevh Vedran , Chen Rui , Defterdarović Jasmina , Kovač Zoran , Mustać Ivan , Bogunović Igor , He Hailong , Baumgartl Thomas , Gerke Horst H. , Toor Gurpal S. , Filipović Vilim
Published: February 2023

Nutrient leaching from agricultural soils presents an economic loss for farmers and can degrade the quality of the surrounding environment. Thus, leachates from 18 in situ wick lysimeters, installed at 40 cm soil depth at the vineyard hilltop, backslope, and footslope intra- and inter-row area (SUPREHILL Critical Zone Observatory, Croatia) were collected monthly over two years and analyzed for major plant nutrient ions. Our objectives were to quantify nutrient losses via leaching from the hilltop towards the backslope and to the footslope, and to compare leaching from vine plant rows (intra-row) with grassed areas between vine rows (inter-row). We found that the concentrations of nitrate, orthophosphate, and potassium were significantly higher in leachates collected at the footslope as compared to the hilltop and backslope only at intra- and not at inter-row positions, while ammonium was independent of the slope and row positions. The vineyard intra-row is identified as the probable spatial origin of nutrient leaching along the slope, thus confirming spatially different contributions of overall hillslope to major plant nutrients leaching. The experimental field scheme used in this study, which separately analyses vineyard intra- and inter-row, was confirmed to be an adequate approach for optimizing vineyard management practices.
Adsorption of Pb, Cu and Cd from Water on Coal Fly Ash-Red Mud Modified Composite Material: Characterization and Mechanism
Authors: Zhao Yuyan , Luan Hanwen , Yang Binghan , Li Zhenghe , Song Meitong , Li Bing , Tang Xiaodan
Published: February 2023

The rational utilization of solid waste has always been a worldwide concern. In this study, coal fly ash (CFA) and red mud (RM) were used in combination to synthesize efficient heavy metal adsorbents. A new way of resource recycling was provided with the collaborative reuse of CFA and RM. To obtain the modified composite materials, CFA and RM were mixed and melted in three ratios. After modification, these materials were then utilized to adsorb Pb, Cu, and Cd in water in both single and ternary systems. The physicochemical properties of CFA, RM, and three modified composite materials were measured by X-ray diffraction analysis, energy dispersive X-ray spectroscopy, scanning electron microscope, Fourier transform infrared spectroscopy, vibrating sample magnetometer, surface area analyzer, and porosity analyzer. In the single and ternary systems, the effects of the modified composite material dosage, solution pH, initial concentration of heavy metals, and adsorption time were discussed, and the results were better fitted with the Langmuir isotherm and the pseudo-second-order kinetic. It was discovered that the modified composite materials had a greater specific surface area (63.83 m2/g) than CFA and RM alone, as well as superior adsorption capacity and magnetic characteristics. The adsorption capacities of C1R4 for Pb, Cu, and Cd were 149.81 mg/g, 135.96 mg/g, and 127.82 mg/g in the single system, while those of Cu and Cd decreased slightly in the ternary system, and the preferential adsorption order of the modified composite materials for heavy metal ions was Pb > Cu > Cd. Among the three modified composite materials, C1R4 had the best adsorption capacity.
Problematic aspects of terminology for sugary confectionery products
Authors:   Department of Commodity Science and Customs Expert Examination, Russian Customs Academy, Krishtafovich D.V. , Kulikova A.G. ,   Faculty of Customs, Russian Customs Academy
Published: February 2023

The article is devoted to the study of terminology and the identifi cation of imperfections and errors in terminology for sugary confectionery products in various regulatory documents. The necessity of harmonization of terms enshrined in regulatory documents of various levels, such as interstate and national standards for sugar confectionery, as well as the EAEU Commodity Nomenclature of Foreign Economic Activity and explanations to it, is shown.
Assortment and assortment policy of tea in retail trade organizations in Moscow
Authors:   Department of International Commerce, Russian Presidential Academy of National Economy and Public Administration, Nikolaeva M.A. , Koteneva A.P. ,   Russian Presidential Academy of National Economy and Public Administration
Published: February 2023

The article presents the results of a survey and analysis of the real trading assortment of tea in the following stores: Azbuka Vkusa, Dixy, and Pyaterochka. It has been established that in the assortment policy of the surveyed stores in the “Tea” subcategory, the predominant main directions are deepening, updating, and improving the assortment in Azbuka Vkusa, and stabilization and harmonization in Dixy and Pyaterochka.
Socio-psychological analysis of foster families’ safety
Authors:   Department of Social Psychology and Social Work, Ryazan State University named after S. A. Yesenin, Sukhov А. N. , Geraskina М. G. ,   Department of Social Psychology and Social Work, Ryazan State University named after S. A. Yesenin
Published: February 2023

The relevance of this work lies in the fact that success is one of the main criteria of life in modern society. With regard to children who are in foster care or under custody, the phenomenon of success acquires increased importance because it is an indicator of how well a child has adapted to society and revealed his/her individual characteristics and talents.The main purpose of our work is to study the factors influencing the successful self-fulfillment of children in foster care or under custody.
The influence of the breed characteristics of fish on the offspring
Authors:   Russian Research Institute of Integrated Fish Breeding — Branch of the Federal Science Center for Animal Husbandry named after academy Member L.K. Ernst, Russia, Moscow region, village named after Vorovsky, Servetnik G.E.
Published: February 2023

It is known that carp with different scaly cover have different economically useful qualities. Thus, linear and naked carp are inferior to scaly and scattered ones in terms of resistance to elevated temperatures, oxygen deficiency, the number of red blood cells, hemoglobin in the blood, and the ability of fins to regenerate. According to the growth rate, scaly carp in most cases are better than scattered ones, and linear ones are better than naked ones. Moreover, the latter grow worse than the first two forms. However, growing conditions play an essential role in the processes of metabolism and growth in carp with different scaly integument, since scaly carp are more of a feeding type, and the other three forms are fattening. The search abilities and feeding capacity of fry in spawning ponds from producers with different scaly cover did not have significant differences, including in the composition of the food lump. The preference of certain objects depended on their concentration in spawning ponds. The assessment of the exterior of fingerlings with scaly and mirrored integument in the conditions of the Stavropol Territory did not reveal any differences in height between them. At the same time, the crossbreeds were superior to the original forms due to the effect of heterosis. The digestibility of nutrients in fingerlings with different scaly integument differed significantly. So the digestibility of the dry matter of the feed was the least in the scaly group, the greatest in the linear. When growing twoyear- olds in the conditions of industrial production in the Smolensk region, a higher growth of mirror carp was noted and a smaller one in naked ones, the differences in exterior and interior were insignificant. The growth of carp of different origins is significantly influenced by growing conditions and, first of all, temperature.
Segurança pública e Polícia Militar: uma revisão sistemática
Authors: Sentone Rafael Gomes
Published: February 2023

O presente estudo tem por objetivo investigar as pesquisas realizadas sobre segurança pública e polícia militar. Como procedimentos metodológicos a pesquisa foi realizada na Brazilian Journals Publicações de Periódicos e Editora Ltda. compondo seis periódicos científicos: Brazilian Journal of Development, Brazilian Journal of Business, Brazilian Journal of Technology, Brazilian Journal of Animal and Environmental Research, Brazilian Journal of Health Review e Brazilian Applied Science Review, em todas as edições publicadas desde a primeira em janeiro de 2015 até dezembro de 2022. Seguindo o Caderno de Descritores em Ciências da Saúde (DeCS) utilizou-se como descritores da pesquisa: polícia, militares, segurança, setor público e os respectivos no idioma inglês: police, military personnel, safety e public sector. Como principais resultados foram identificados 33.004 estudos publicados dos quais 113 são da temática delineadas. Foram agrupados em seis áreas sendo: educação, gestão, legislação, operações, saúde e tecnologia, havendo um crescimento significativo ao longo dos anos sendo 3 publicados em 2019 (2,6%), outros 16 publicados em 2020 (14,1%), mais 36 publicados em 2021 (31,8%) e 58 publicados em 2022 (51,3%). Em que pese haja um número considerável de publicações sobre segurança pública, na mesma proporção os ensaios revelam discussões superficiais, além de poucos estudos nas áreas da educação e tecnologia, precursoras do desenvolvimento da segurança pública.
Técnicas alternativas de correção de manifestações patológicas na ponte Dom Affonso Felippe Gregory
Authors: Costa Jardylene Almeida , Sousa Pedro Manoel Lima Gustavo , Machado Vitor de Sousa , Duarte Francisco Raphael Lima , Silva Helde Costa , Oliveira Maria Rebeca Sousa , Carvalho Victor Bezerra , Teixeira Fawan Lima , Gomes Randal Silva
Published: February 2023

O presente artigo identifica por meio de uma vistoria técnica e revisão bibliográfica, as manifestações patológicas presentes na ponte Dom Affonso Felippe Gregory, uma obra de arte especial responsável pela mobilidade rodoviária sob o rio Tocantins na fronteira dos estados do Maranhão e Tocantins. Tendo como objetivo geral apontar alternativas técnicas viáveis para recuperação dos problemas abordados, que possam ser utilizadas pelos administradores da obra, buscando propiciar melhoria na segurança, durabilidade, economia e conforto do patrimônio. Uma das causas do aparecimento dessas manifestações patológicas é a falta de manutenções periódicas na ponte, que tem como consequência a deterioração da mesma, que pode ocasionar o comprometimento à renda de mercadorias que necessitam deste modal viário para subsistência. Os resultados obtidos apresentam soluções para os problemas patológicos contidos na ponte, sendo estes: desagregação e buracos no revestimento do pavimento; corrosão das armaduras de aço; desgaste superficial do piso de concreto; deterioração das juntas de dilatação e deficiência do sistema de drenagem; fissuras no concreto armado; desagregação e lixiviação do concreto. Através disso, é concluído que a aplicação das alternativas técnicas apresentadas em conjunto com inspeção e manutenção periódica pode devolver à ponte qualidade e garantir a vida útil da estrutura.
Intralesional administration of meglumine antimoniate (MA) as an alternative treatment for cutaneous leishmaniasis: a case report
Authors: De Souza Marcos Vilela , Cherem José , Dos Santos Júnior Gilson Argolo , César Antônia Amanda da Silva , Narciso Thiago Pasqua , Alvarenga Ingrid Marciano , Barçante Thales Augusto , Barçante Joziana Muniz de Paiva
Published: February 2023

Cutaneous leishmaniasis (CL) is not a life-threatening condition, the treatment of which can cause serious adverse effects and sometimes lead to death. In this study, we report a case of success in the treatment of LC of a 2.5 cm lesion located in the neck region of a 22-year-old man treated with intralesional meglumine antiomoniate (IL-MA) without adverse effects and without recurrence or complications after 18 months of follow-up. The results suggest that the treatment of CL lesions with IL-MA is simple, efficient and safe.
Perfil bacteriológico e regimes antibióticos utilizados no tratamento da Gangrena de Fournier
Authors: Ochoa Danilo Xavier Torres , Montesinos Carlos Enrique Flores , Ortiz Glenda Iris Montenegro
Published: February 2023

Objetivo: determinar o perfil bacteriológico e os regimes antibióticos utilizados para o tratamento da Gangrena de Fournier. Método: Foi realizada uma Revisão Bibliográfica. Os artigos foram selecionados a partir das seguintes bases de dados: ProQuest (https://www.proquest.com/), PubMed (https://pubmed.ncbi.nlm.nih.gov/), e ScienceDirect (https://www.sciencedirect.com/) em espanhol ou inglês, usando descritores e operadores booleanos AND e OR. Resultados: O perfil bacteriológico da gangrena de Fournier é principalmente do tipo polimicrobiano, com maior presença de bactérias gram-negativas e anaeróbicas, entre as quais as mais importantes são Escherichia coli, Proteus mirabilis, Klebsiella pneumoniae e Bacteroides fragilis. As bactérias gram-positivas, as mais proeminentes são Staphylococcus aureus e Streptococcus spp. Há também bactérias multiresistentes, principalmente Escherichia coli blee e Staphylococcus aureus resistente à meticilina. Quanto ao tratamento, existem múltiplos regimes antibióticos, sendo o mais amplamente utilizado e recomendado: cefalosporina de terceira geração mais aminoglicosídeo mais metronidazol. Conclusão: a gangrena de Fournier é uma patologia rara, mas muito devastadora, difícil de tratar e com um prognóstico ruim. A infecção é principalmente polimicrobiana e o tratamento antibiótico necessário é de amplo espectro.
A comunicação da equipa na promoção da segurança da pessoa em situação crítica: uma revisão integrativa da literatura
Authors: Teixeira Joana Moreira Ferreira , Oliveira Paula Cristina Aguiar
Published: February 2023

Introdução: A comunicação é parte integrante do plano de intervenção em saúde, pelo que cuidar de alguém sem comunicar não é possível. A comunicação, quando ineficaz, é um dos principais fatores para ocorrência de eventos adversos, sendo que a transição de cuidados é um momento de grande vulnerabilidade para que falhas de comunicação aconteçam. Cuidar da pessoa em situação crítica reveste-se de grande complexidade, envolvendo equipas multidisciplinares em que o risco de uma comunicação ineficaz está subjacente, pelo que se torna fundamental a aplicação de estratégias de comunicação que promovam a comunicação eficaz, de forma a garantir a qualidade e segurança da pessoa e família. Objetivo: Conhecer estratégias de comunicação a utilizar pela equipa de cuidados para uma transição segura de cuidados da pessoa em situação critica e família. Metodologia: Foi efetuada uma Revisão integrativa da literatura, através da pesquisa nas bases de dados CINAHL e MEDLINE e em outras fontes. Foram estabelecidos critérios de inclusão e exclusão para seleção dos documentos. Resultados: Identificaram-se 95 documentos. Após verificação da elegibilidade dos mesmos, foram selecionados 13 documentos finais para análise e extracção dos dados. Conclusão: O uso de ferramentas padronizadas, uma linguagem estruturada e o uso de checklists são fundamentais para uma transição segura de cuidados da pessoa em situação crítica. Investir na formação interdisciplinar traz benefícios para os doentes, profissionais e sistemas de saúde.
Behcet’s disease; a narrative review with a focus on autoimmunity processes in involved organs
Authors: Ebrahimi Fard Zeynab , Balasi Javad , Kimiaefar Atiyeh , Jazi Kimia , Hajrezaei Zahra , Karami Jafar , Banitaba Seyyed Mohsen , Masoumi Maryam
Published: February 2023

Behcet’s disease (BD) is an autoimmune and inflammatory disease that is mainly characterized by involvement of the gastrointestinal tract, cardiovascular system, genital tract and joints. The disease is more common in the Middle Eastern and Far Eastern countries and the frequency of recurrences and attacks varies among populations. Although the pathogenesis is not fully understood, there is evidence to suggest that immunodeficiency and specific patterns of production of immune regulatory mediators are important. Impaired autoimmune and inflammatory cells, target endothelial cells and prompt vasculitis in the involved organs. Elucidating the immunological mechanism of BD can facilitate the development of new therapies and therapeutic immunoregulatory interventions to prevent possible complications. New therapies, including manipulation of immune-regulating mediators such as interferon-alpha antagonists, have shown promising results in patients with BD. This review aims to consider the role of auto-inflammatory and autoimmune processes and related factors which give rise to the different manifestations of the disease in each involved organ.
Permanent complications after thyroid surgery and effect of surgeon volume
Authors: Abrishamkar Esfahani Bahareh , Amini Masoud , Aminorroaya Ashraf , Kolahdouzan Mohsen , Nazem Masoud , Salehidoost Rezvan
Published: February 2023

Introduction: Thyroidectomy is a surgical method for the management of benign and malignant thyroid disease. Thyroidectomy may cause significant complications including hypocalcemia and recurrent laryngeal nerve injury. Permanent complications after thyroid surgery pose significant costs for healthcare system, as patients require lifelong alternative treatments and healthcare facilities. Objectives: The purpose of this study was to evaluate the incidence and risk factors for permanent complications following thyroidectomy. Patients and Methods: A total of 204 consecutive patients who underwent thyroid surgery between 2017 and 2018 were included in this prospective study. The patients were followed for 12 months after surgery and clinical and biochemical data were recorded. Results: The incidence of transient and permanent hypocalcemia was 46.8% and 6.38%, respectively. Transient hoarseness affected 30.3% of patients and 2.1% had recurrent laryngeal nerve paralysis as detected by video laryngoscopy 12 months after surgery. Surgeons volume was significantly related to the presence of permanent hypocalcemia (P=0.003). In comparison to high-volume-surgeons, intermediate-volume-surgeons had an odds ratio of 5.25 (P=0.042) for permanent complications. Conclusion: Hypocalcaemia remained the most common long-term complication of thyroid surgery. High volume surgeons had lower complication rates and better outcomes. In this regard, methods for improving surgical performance are worthy of investigation.
Ursodeoxycholic acid and phototherapy versus phototherapy and placebo on neonatal indirect hyperbilirubinemia
Authors: Zadkarami Masood , Rahimpour Foroozan , Hardani Amir Kamal , Javaherizadeh Hazhir
Published: February 2023

Introduction: Recently ursodeoxycholic acid was recommended for the treatment of neonatal hyperbilirubinemia in a few studies. Objectives: This study aimed to compare ursodeoxycholic acid and phototherapy versus phototherapy in lowering the level of bilirubin in neonates who was admitted due to hyperbilirubinemia. Patients and Methods: This randomized double-blind study was carried out in the department of neonatology at the children’s medical center of Ahvaz Jundishapur of the University of Medical Sciences. Inclusion criteria were weight 2500-4200 g and exclusive breastfeeding. Gestational age between 38-41 weeks and age between 3-7 days were included. Total bilirubin between 14-20 according to Bhutani nomogram and direct bilirubin was less than 2 mg/dl was included. Exclusion criteria were ABO incompatibility, Rh incompatibility, G6PD (glucose6-phosphate dehydrogenase) deficiency, sepsis, hypothyroidism, liver problem, prematurity and newborn of diabetic mothers. A dose of 5 mg/kg per dose of ursodeoxycholic acid (UDCA) was prescribed for neonates every 12 hours. Placebo is also prescribed for other neonates. Unconjugated bilirubin was measured after 4 hours and every 12 hours till total bilirubin=12 mg/dL. The primary outcome measures were total bilirubin level four hours and every 12 hours after admission till reached 12 mg/dL. The secondary outcome measure was total bilirubin=12 mg/dL at 12-24 hours after admission and diarrhea, vomiting, skin rash or any adverse effect in the neonates who received UDCA. Neonates who underwent phototherapy and UDCA were the case group. Neonates who received phototherapy and placebo were allocated in the control group. Data were analyzed using SPSS version 16.0. Kolmogorov-Smirnov test was conducted to evaluate data distribution. Intention-to-treat analysis was used. Mann-Whitney U test was conducted for data analysis. Results: In the current study, 30 cases and 30 control were included. Discharged neonates were 96% among the UDCA group and 87% among the control group in the 1st 24 hours after admission. Among the UDCA group, 100% were discharged at the 2nd 24 hours of admission and 96% among the control. The duration of phototherapy was shorter in the case group than in the control group, however this difference had no statistical difference. Conclusion: No significant difference between neonates who underwent phototherapy and phototherapy+ UDCA in terms of duration of phototherapy and bilirubin reduction was found. Trial Registration: The trial protocol was approved by the Iranian Registry of Clinical Trials (identifier: IRCT20181003041225N1; https://en.irct.ir/trial/34272, ethical code; IR.AJUMS.REC.1397.899).
Zinc level alternation after phototherapy in neonates with hyperbilirubinemia
Authors: Goodarzi Rakhshaneh , Saadat Seyed Hossein , Janbozorgi Fatemeh , Darban Behnaz
Published: February 2023

Introduction: One of the old treatment methods for unconjugated hyperbilirubinemia in neonates is blood exchange transfusion, which is expensive, possibly high-risk, and time-consuming. Today phototherapy as a novel method can be a good alternative. Objectives: This study aimed to evaluate the zinc level alternation after phototherapy in neonates with hyperbilirubinemia. Patients and Methods: A descriptive-analytical study was conducted on 85 infants with hyperbilirubinemia who underwent phototherapy referred to the pediatric hospital in Bandar- Abbas, Iran from 2017 to 2018. Healthy infants over two days with idiopathic jaundice with a gestational age greater than 34 weeks and only breast-feed were enrolled. Serum zinc levels were measured before and after phototherapy, and their changes were evaluated. Results: Out of 85 neonates, 42 (49.4%) were male and 43 (50.6%) were female with a mean gestational age of 37.83 ± 0.58 weeks and admission age of 4.15 ± 1.70 days. Zinc level before phototherapy was 84.98 ± 52.06 (μg/dL) and after phototherapy was 234.41 ± 280.98. The difference between serum zinc levels before and after the phototherapy was significant therefore, the zinc level significantly increased after the phototherapy. Conclusion: Results showed that phototherapy increases serum zinc levels, which can cause zinc toxicity. It is wise to measure serum zinc levels before and during phototherapy and seek the appropriate medical care.
Introducing a very rare case of intra-pericardial thyroid tissue with blood supply from the aortic arch in a patient with renal cell carcinoma: A case report and review of the literature
Authors: Hekmat Manouchehr , Ghaderi Hamid , Hekmat Mahya , Ansari Aval Zahra , Mirjafari Seyedeh Adeleh , Tirdad Roshanak
Published: February 2023

Intra-pericardial heterotopic thyroid (IPHT) is an incidental finding during open-heart surgery. Although heterotopic thyroid has been reported in different parts of the body, only a few cases of intra-pericardium have been reported so far. In most articles, intracardiac, intrathoracic and heterotopic thymus cases are mistakenly included as IPTH cases A 57-year-old man with a history of non-Hodgkin lymphoma, who was treated 8 years ago and recovered, is now a candidate for surgery due to clear cell renal carcinoma in the left kidney with inferior vena cava (IVC) thrombus tumor that has spread into the right atrium. At the same time, he was operated on by two teams of urology and heart surgery. The patient’s kidney was removed, and then he was subjected to sternotomy by the heart surgery team to remove the thrombus tumor. After opening the pericardium inside the pericardial cavity, a pericardial mass measuring 1×2 ×3 cm, which was connected to the lower surface of the aortic arch by a 1 cm long stalk, was observed. It was resected and sent to pathology laboratory. The rest of the surgery to remove the thrombus tumor from inside the right atrium and IVC continued according to the procedure. The pathological report was benign thyroid tissue. Actual cases of IPTH are underreported, and due to the small number, it is not yet possible to comment on the prevalence of malignancy in it or its functional role; However any lesion or abnormal mass in the pericardial cavity should be respected and sent to pathology laboratory therefore by collecting information about these masses, in the future, decisions can be made and summarized.
Impact of metformin on hypertension; current knowledge
Authors: Bakhshaei Sina , Bakhshaei Bina , Sotoudehnia Korani Setayesh , Alamouti-Fard Emad , Allamiaghmiouni Leila , Neshat Sina
Published: February 2023

High blood pressure is a potential adjustable risk factor for vascular complications of diabetes. Numerous categories of anti-hypertensive medications have proven to effectively reduce these complications. Additionally, metformin, besides lowering glucose and lipid levels, has advantages on vascular blood flow and improving endothelial function. In this review, we investigate the potential benefits of metformin in lowering blood pressure. Previous studies suggested that the administration of metformin to non-diabetic patients could efficiently reduce systolic blood pressure. The whole comparison of the evidence shows that metformin may have small effects on lowering blood pressure; however, this effect is not directly via a change in sympathetic activity. Mechanisms of blood pressure reduction by metformin may be due to its indirect effects on insulin resistance, nephroprotective, cardioprotective, improvement of the sympatric nerve system, and endothelial function.
A mini-review to the common adverse-effects of statins
Authors: Nasri Hamid
Published: February 2023

HMG-CoA (3-hydroxy-3-methyl glutaryl coenzyme A) reductase inhibitors are associated with muscle injury. Chronic kidney disease (CKD) carries a high risk for the development of statin-induced myopathy. Statin therapy decreases the absolute risk of cardiovascular diseases in patients with CKD; however, rhabdomyolysis increases with deteriorating kidney function.
Colchicine and the concepts of nephroprotection; a new feature of an old drug
Authors: Nasri Hamid
Published: February 2023

Colchicine as an old drug and is usually the first choice of treatment for acute gout to reduce pain and inflammation. Colchicine seems to prevent various pro-inflammatory mechanisms, whereas it allows increasing concentration of anti-inflammatory molecules, which leads to clinical advantage in patients with gout. Colchicine is using generally as a treatment for acute gout however, it has also newly been revealed to have anti-fibrotic effects in different kinds of nephropathies such as polycystic kidney disease, diabetic nephropathy and amyloidosis. Extended use of colchicine is associated with nephrotoxicity depending on its dose, which results to impairment of renal function. Risk of colchicine therapy is accentuated in chronic kidney disease (CKD) patients; therefore, dose reduction is necessary dependent on CKD stage.
The effect of lycopene on contrast-induced nephrotoxicity in diabetic patients undergoing coronary angiography
Authors: Mahmoudnia Leyla , Abkhou Farzad , Bazdar Ali , Ganji Forouzan , Momenzadeh Mahnaz
Published: February 2023

Introduction: Radiocontrast nephrotoxicity refers to one of the most prevalent and key complications in diabetic patients. Objectives: This study was aimed to investigate the therapeutic and protective effect of lycopene on contrast-induced nephrotoxicity (CIN) in diabetic patients undergoing coronary angiography. Patients and Methods: In this study, 113 patients who took lycopene with prevention of contrast induced kidney injury regime (lycopene group) or prevention of kidney injury regimen alone (regimen group) were investigated through medical records. Oral lycopene was administered 24 hours before to 72 hours after the angiography. Blood urea nitrogen (BUN), creatinine (Cr), and glomerular filtration rate (GFR) were assessed and recorded in a checklist. SPSS software was conducted for data analysis. Results: At the baseline, there was no significant difference between the mean of urea, Cr, and GFR (P>0.05). However, after administration of lycopene, a significant difference between the mean BUN was observed among groups (P<0.001), with lower rate in the patients taking oral lycopene. Although the mean Cr decreased after the administration of oral lycopene, no statistically significant difference was seen (P = 0.08). The mean GFR was not significant different between the two groups of regimen and lycopene (P=0.44). Conclusion: In patients with diabetes, taking lycopene for CIN may help improve some biochemical factors; nevertheless, its positive effect on the improvement of nephrotoxicity indices cannot be certainly determined.
Aloe vera applications and Aloe vera based nanomaterials
Authors: Koratala Anoop , Chandra Nikitha Chowdary , Rabiei Yassamin , Rezvani Zeinab , Neshat Sina
Published: February 2023

Three different formations of Aloe vera are frequently used in therapeutic applications, which are completely diverse in their biochemical content and beneficial characteristics, latex, gel, and extract. Recently, investigators have employed Aloe vera with new decomposable efficient biomaterials and nanostructures for targeting applications like tissue engineering, drug delivery systems, the remedy of various diseases, the food industry, and the removal of pollutants. Numerous different nanostructures made by Aloe vera for different applications are presented in this review.
THE IMAGE OF THE OLD MAN IN ALEXANDER BLOK’S POETRY OF THE 1900S
Authors: Koptelova Natalya G.
Published: February 2023

The article makes a certain contribution to the study of the typology of Alexander Blok’s characters, which arose as a result of the “theatricalisation” of the lyrical subject. We examine examples of some lyrical monologues written on behalf of the old man. Their aesthetic nature is revealed, poetics and functions are characterised. It is proved that the lyrical monologues of the old men” created in Alexander Blok’s poems of the 1900s (“Under old age, forgetting the sacred...”, “When I began to grow decrepit and get cold...”, “Years have passed, but you are still the same...”, “The Double”) form a special local artistic integrity within his poetic “trilogy”. It is shown that in the spontaneously formed ensemble unity, the image of the old man turns out to be Alexander Blok’s “lyrical mask“, his tragic double and in many respects expresses autopsychological experiences associated with the idea of “betrayal“ of the mystical ideal of Eternal Femininity. The article emphasises that the poems (“Under old age, forgetting the sacred...”, “When I began to grow decrepit and get cold...”, “Years have passed, but you are still the same..” form an intersubjective paradigm. In these works, the image of the old men correlates not only with the personality of Alexander Blok and Dmitry Merezhkovsky, but also allows us to perceive the character as a completely independent hero with a unique character. The paper concludes that the “theatricality” of poetics is most clearly and clearly manifested in the poem “When I began to grow decrepit and get cold...”, as if oriented towards oral pronunciation and stage incarnation.
FOLKLORE STEREOTYPES AS A STYLISTIC FEATURE OF ALEXANDER OSTROVSKY’S PLAYS: SPEECH OF MATCHMAKER WOMEN
Authors: Gantsovskaya Nina S.
Published: February 2023

The problem of speech stereotypes of the Russian wedding ceremony in the texts of works of fiction is discussed in the paper. What is subjected to specific analysis are the plays by Alexander Ostrovsky with the theme of matchmaking, where samples of oral folklore and wedding rituals are widely represented in the speech of the matchmakers. The samples of their poetry, replete with folkish and ritual wedding elements, are presented in the article with their analysis given from the side of content and form as well as comparison with their authentic folkish oral prototypes, including ones fixed on Kostroma soil as well, is made. The study is based on the works of well-known Russian folklorists who devoted their work to studying local traditions of the Russian wedding speech genres and folklore patterns accompanying them. Historical and cultural links of Alexander Ostrovsky’s dramaturgical creative work with live folklore and ritual folk traditions are established. In this respect, the high appreciation of the archival folklore and ritual collections of Kostroma, including the one in the walls of Kostroma State University, is revealed by the experts. In conclusion, it is pointed out that folklore speech elements in Alexander Ostrovsky’s drama are of substantial and stylistic importance, and these includes elements of Russian wedding ceremonies and many typified poetic examples of oral folklore conveyed through the speech of matchmakers.
REFLECTION OF FOREIGN CULTURAL INFLUENCES IN THE FOLKLORE AND LANGUAGES OF THE PEOPLES OF DAGESTAN
Authors: Magomedov Amirbek Dj. , Gasharova Aida R.
Published: February 2023

The article examines the influence of the Russian language and culture on the folklore and language of the peoples of Dagestan. It is noted that with the direct participation of otkhodniks at the beginning of the 20th century, the number of neologisms increases in the folklore and lexical composition of the Dagestan languages. This is explained by the fact that the dynamics of the phenomena of everyday life of otkhodniks of that period was associated with the city. The purpose of the study is to show the foreign cultural, urban, exotic influences reflected in the oral and poetic creativity, the languages of Dagestan. The authors made an attempt to identify the role of intercultural communication in these processes. Most clearly, other cultural, urban motifs are manifested in folklore, namely, in oral stories and non-ritual lyrics (songs about otkhodnichestvo). The otkhozhny trade has become widespread among a number of Dagestan peoples (Dargins, Lezgins, Laks and Tabasarans). Borrowed words and expressions found in folklore texts make it possible to trace the processes of interethnic contacts and intercultural communications of that era. Folklore and linguistic picture of the world in the late nineteenth and early twentieth centuries. become a mirror of such communications. In general, the topic did not become the object of a special study. The issue of borrowing Russianisms is considered in monographs devoted to the branch vocabulary of the Dagestan languages, in articles on folklore.