bluuebunny/crossref_metadata_2025 huggingface dataset:
Study protocol of the ASTOP trial: A multicenter, randomized, double-blind, placebo-controlled trial of presurgical aspirin administration for the prevention of thromboembolic complications of coil embolization for ruptured aneurysms
Authors: Hirai Sakyo , Fujita Kyohei , Fujii Shoko , Takahashi Satoru , Shigeta Keigo , Karakama Jun , Enomoto Yukiko , Sato Yohei , Yoshimura Masataka , Hirota Shin , Mizoue Tatsuya , Yoshino Yoshikazu , Kawano Yoshihisa , Yamamura Toshihiro , Kohyama Shinya , Hirohata Masaru , Yoshimura Shinichi , Ishii Yosuke , Yamauchi Toshihiro , Taira Naoki , Obata Yoshiki , Sakamoto Makoto , Inoue Masato , Yamashina Motoshige , Tokunaga So , Higashi Toshio , Sawada Kana , Mochida Hidetoshi , Ido Keisuke , Takeuchi Masataka , Takigawa Tomoji , Takagi Yasushi , Morimoto Masafumi , Nanto Masataka , Miki Kazunori , Misaki Kouichi , Arimura Koichi , Hanaoka Yoshiki , Hara Mutsuya , Hara Shoko , Yokoyama Kota , Ooyama Jun , Hanazawa Ryoichi , Sato Hiroyuki , Hirakawa Akihiro , Ishiguro Megumi , Nemoto Shigeru , Sumita Kazutaka
Published: September 2024

Rationale

Thromboembolism is a serious complication of endovascular treatment for ruptured cerebral aneurysms. The administration of antiplatelet agents before endovascular treatment for ruptured cerebral aneurysms may reduce the risk of thromboembolic complications.

Aim

This study aimed to assess the safety and efficacy of preoperative aspirin administration in endovascular treatment for ruptured cerebral aneurysms.

Sample size estimates

Assuming a 15% incidence rate of both intraoperative thromboembolic morbidity and symptomatic ischemic lesions on magnetic resonance imaging diffusion-weighted imaging scans assessed by an Independent Review Committee, a sample size of 484 will be required to detect a 10% improvement with aspirin administration with 90% power using the Pearson’s chi-square test at a two-sided significance level of 2.5% for each primary outcome, after accounting for a 5% dropout rate.

Methods and design

ASTOP is a multicenter, randomized, double-blind, placebo-controlled clinical trial. A total of 484 patients with ruptured cerebral aneurysms receiving coil embolization within 72 h of onset will be randomly assigned 1:1 to receive 200 mg of aspirin or placebo before the procedure.

Study outcomes

The primary outcomes will be the incidence rates of intraoperative thromboembolic complications and symptomatic ischemic lesions on magnetic resonance imaging diffusion-weighted imaging scans evaluated by the Independent Review Committee. The secondary outcomes will be the incidence rate of cerebral ischemic events and all bleeding events within 14 days of enrollment and functional outcomes defined by the modified Rankin Scale score at 90 days.

Discussion

This trial will provide valuable data on the role of antiplatelet agents during endovascular treatment for ruptured cerebral aneurysms.

Trial registration

Registration: Japan Registry of Clinical Trials, Identifier: jRCTs031210421.
On Frenet Apparatus of Curves in Rn
Authors: Barbosa Isnaldo , Seixas J. Adonai
Published: September 2024

In this paper, we present new explicit and nonrecursive formulas for the curvatures and the frame of Frenet of a regular curve with an arbitrary parameter in the Euclidean space Rn, n > 2, expressed only in terms of its derivatives.
Poincar´e duality and the existence of exotic structures on n-spheres
Authors: Silva Ribeiro Maico Felipe , Nery de Oliveira Leandro , Da Silva Thiago Filipe
Published: September 2024

Poincar´e duality is a remarkable result in Algebraic Topology. It guarantees the existence of an isomorphism between the homology and cohomology groups of manifolds. We present a survey of the most general version of this result and its most important variations such as the Lefschetz duality and the Alexander duality. We consider an important application of these results in the study of the existence of exotic structures on n-spheres.
Pityriasis lichenoides acuta after COVID-19 vaccination
Authors: Singh Maneesh
Published: September 2024

This case is notable due to the possible association between pityriasis lichenoides et varioliformis acuta (PLEVA) and the COVID-19 vaccination. In this case report we discuss a case of a 32 year-old male who developed erythematous, oval-shaped papules on his trunk, upper and lower extremities 2 weeks after his Covid 19 vaccination.

We also discussing the the diagnostic and therapeutic challenge of this disease and how a misdiagnosis of this disease can lead to great amount of emotional and psychological stress for the patient and his family members. For this reason it is important to have this on the list of possible diagnosises.
Non-trivially true statements in computability with the predicate K of the current mathematical knowledge, which do not express the current mathematical knowledge and may be falsified
Authors: Tyszka Apoloniusz
Published: September 2024

The theorem of Royer and Case states that there exists a limit-computable function β_1:N→N which eventually dominates every computable function δ_1:N→N. We present an alternative proof of this theorem. K denotes both the knowledge predicate satisfied by every currently known theorem and the finite set of all currently known theorems. The set K is time-dependent and publicly available. Any theorem of any mathematician from past or present forever belongs to K. The statement ¬K(P≠NP)∧¬K(P=NP) does not justify the title of the article. We prove: (1) there exists a limit-computable function f:N→N of unknown computability which eventually dominates every function δ:N→N with a single-fold Diophantine representation; (2) for every computable functions g:N→N, there exists a limit-computable function f:N→N of unknown computability such that f eventually dominates every function δ:N→N with a single-fold Diophantine representation and f(n)>g(n) for every n∈N. Both (1) and (2) justify the title of the article.
Review of Hereditary non-polyposis colorectal cancer
Authors: Singh Maneesh
Published: September 2024

The purpose of this paper is to provide a review of hereditary non-polyposis colorectal cancer. This paper covers the causes, epidemiology, pathophysiology, histology, diagnosis, and treatment for the disease.
Model for detecting anomalies and suspicious transactions on financial and non-financial entries
Authors: Kpinna Tiekoura Coulibaly , Digrais Moïse Mambe , Moustapha Diaby
Published: September 2024

Some conventional audit methods sometimes fall short in identifying subtle irregularities and emerging fraudulent schemes. Our proposal is therefore part of the aim of improving audit processes. At the end of the experiments on two sets of data, our model offers the best results compared to other models, particularly in terms of CPU execution time of the model and also in terms of performance in the detection of normal data with a better rate of false positives.
Comparative analysis of some linear predictive models in the presence of multicollinearity
Authors: Q.A Owoyemi , A. Bolakale
Published: September 2024

This paper investigates the comparative performance of some linear predictive models in the presence of multicollinearity. By examining the efficacy of Ordinary Least Squares (OLS), Ridge Regression, Lasso Regression, and Elastic Net Regression, this study aimed to figure out the best method for building robust and interpretable models under such conditions. The research explores how these models address multicollinearity, focusing on coefficient stability, prediction accuracy, and variable selection. Through a rigorous analysis of simulated and real-world datasets, the study shows the strengths and weaknesses of each model, providing valuable insights for researchers and practitioners looking to mitigate the challenges posed by multicollinearity in selecting the most proper method for regression modeling. This will lead to the creation of a model with increased interpretability of the relationships between variables, less variance, and more dependable coefficient estimations.
Response Surface Optimization of the Critical Medium Components for the Production of α-Galactosidase from Aspergillus parasiticus MTCC-2796
Authors: Shivam Kumar , Mishra S. K.
Published: September 2024

Response surface methodology was used to evaluate the effect of main variables such as concentration of galactose, yeast extract and wheat bran on α-galactosidase production from Aspergillus parasiticus MTCC-2796 under submerged fermentation conditions. A full factorial Central Composite Design was applied to study these main factors that affected α-galactosidase production. The experimental results showed that the optimum concentration of galactose, yeast extract and wheat bran were 1.5 %, 0.06 % and 1.5 %, respectively. This method was efficient as only 20 experiments were necessary to asses these conditions, and model adequacy was very satisfactory as the coefficient of determination was 0.9921.
Die wissenschaftlichen Bibliotheken der DDR nach der Wiedervereinigung
Authors: Knoche Michael
Published: September 2024

Die Transformation der wissenschaftlichen Bibliotheken der DDR nach der Wiedervereinigung führte zu einer Modernisierung von Strukturen, Bestand und Technolgie sowie zu einer personellen Erneuerung. Das Zusammenwirken von ost- und westdeutschen Bibliothekaren hat sich von der ersten Stunde an als äußerst produktiv erwiesen. Vom Transformationsprozess hat das gesamte deutsche Bibliothekssystem profitiert, insbesondere die Verbünde. Standardisierung und Anwendung von Normdaten wurden beschleunigt, überregionale Projekte gewannen an Substanz.
Solvability of infinite system of integral equations of Hammerstein type in three variables in tempering sequence spaces
c
0
β
{c}_{0}^{\beta }
and
ℓ
1
β
{\ell }_{1}^{\beta }
Authors: Simbeye Mesia , Kumar Santosh , Mursaleen M.
Published: September 2024

The objective of this study is to determine the criteria under which the infinite system of integral equations in three variables has a solution in the Banach tempering sequence space

c

0

β

{c}_{0}^{\beta }

and

ℓ

1

β

{\ell }_{1}^{\beta }

, utilizing the Meir-Keeler condensing operators. Our research builds upon the findings of Malik and Jalal. Furthermore, we provide illustrative examples to demonstrate the implications of our established conditions.
Assessment of sugarberry as a host tree of Halyomorpha halys (Hemiptera: Pentatomidae) in southeastern USA agroecosystems
Authors: Tillman Patricia Glynn , Cottrell Ted E. , Kesheimer Katelyn A. , Grabarczyk Erin E.
Published: September 2024

The brown marmorated stink bug, Halyomorpha halys (Stål) (Hemiptera: Pentatomidae), is an invasive, polyphagous pest known to disperse between non-crop host plants and crops searching for food. Sugarberry (Celtis laevigata Willdenow; Cannabaceae) is commonly found in woodland habitats in the southeastern USA and may serve as a non-crop host for H. halys. Therefore, the main objective of this two-year study was to determine if 1) sugarberry serves as a host tree and 2) whether natural enemies attack H. halys sentinel egg masses in the tree canopy. We monitored H. halys in sugarberry trees in woodlands bordering field crops in Prattville, Alabama during 2022 and similarly for orchard crops in Byron, Georgia during 2023. Each year pheromone-baited stink bug traps were deployed in the canopy of trees to capture H. halys. We evaluated parasitism and predation of H. halys by placing sentinel egg masses in tree canopies. H. halys males and females and 2nd through 5th instars were captured in tree traps over the season for each location. Trissolcus euschisti (Ashmead) (Hymenoptera: Scelionidae) was the only parasitoid species that emerged from H. halys eggs. Chewing and stylet sucking were the primary types of predation on sentinel egg masses. We conclude that sugarberry is a reproductive host for H. halys, and native natural enemies provide biological control services of H. halys eggs on this host.
Promoting the sustainable construction: A scientometric review on the utilization of waste glass in concrete
Authors: Qayyum Arshad , Javed Muhammad Faisal , Asghar Raheel , Iqtidar Ammar , Alabduljabbar Hisham , Khan Mohsin Ali , Ali Mujahid
Published: September 2024

Concrete is the second-most used material globally and significantly impacts the environment by emitting a large amount of carbon dioxide (CO2). This scientometric review investigates the sustainable use of waste glass (WG) in concrete. Our study examines the impact of waste glass powder (WGP) on the mechanical and fresh characteristics of concrete and its environmental implications, enhanced by a machine learning prediction model. We observed a progressive increase in research activity on WGP-based concrete since 2000, indicating the growing interest in this area. The primary focus areas are engineering and material science, reflecting the application potential, structural performance, and material properties of WGP-based concrete. Our discussions highlight the significant benefits of WGP in concrete, including its potential to reduce landfill usage, environmental pollution, and enhance properties such as strength, sulfate resistance, alkali–silica reaction resistance, and freeze–thaw resistance. The review also explores the microstructure of glass powder (GP)-based concrete, illuminating the complex interactions between glass particles and the concrete matrix, which influence the material’s overall performance. Environmental impact assessments underscore the necessity for sustainable construction practices and waste reduction. Utilizing machine learning prediction models helps optimize the composition of GP-based concrete, thus enhancing material performance and durability. This review provides a comprehensive analysis of using WG in concrete, contributing to the field’s understanding and informing future research and innovations to optimize WG use in concrete applications.
Involvement of kinases in memory consolidation of inhibitory avoidance training
Authors: Montiel Ivan , Bello-Medina Paola C. , Prado-Alcalá Roberto A. , Quirarte Gina L. , Verdín-Ruvalcaba Luis A. , Marín-Juárez Tzitzi A. , Medina Andrea C.
Published: September 2024

The inhibitory avoidance (IA) task is a paradigm widely used to investigate the molecular and cellular mechanisms involved in the formation of long-term memory of aversive experiences. In this review, we discuss studies on different brain structures in rats associated with memory consolidation, such as the hippocampus, striatum, and amygdala, as well as some cortical areas, including the insular, cingulate, entorhinal, parietal and prefrontal cortex. These studies have shown that IA training triggers the release of neurotransmitters, hormones, growth factors, etc., that activate intracellular signaling pathways related to protein kinases, which induce intracellular non-genomic changes or transcriptional mechanisms in the nucleus, leading to the synthesis of proteins. We have summarized the temporal dynamics and crosstalk among protein kinase A, protein kinase C, mitogen activated protein kinase, extracellular-signal-regulated kinase, and Ca2+/calmodulin-dependent protein kinase II described in the hippocampus. Protein kinase activity has been associated with structural changes and synaptic strengthening, resulting in memory storage. However, little is known about the molecular mechanisms involved in intense IA training, which protects memory from typical amnestic treatments, such as protein synthesis inhibitors, and induces increased spinogenesis, suggesting an unexplored mechanism independent of the genomic pathway. This highly emotional experience causes an extinction-resistant memory, as has been observed in some pathological states such as post-traumatic stress disorder. We propose that the changes in spinogenesis observed after intense IA training could be generated by protein kinases via non-genomic pathways.
Green synthesized AgNPs of the Anchusa arvensis aqueous extract resulting in impressive protein kinase, antioxidant, antibacterial, and antifungal activities
Authors: Mohany Mohamed , Ali Jamshed , Wahab Abdul , Fozia Fozia , Shah Syed Majid , Gul Rukhsana , Gul Ahmad , Ahmad Ijaz , Milošević Marija , Al-Rejaie Salim S. , Aboul-Soud Mourad A. M.
Published: September 2024

This study focused on analyzing the pharmacological activities of AgNPs synthesized from an aqueous plant extract of Anchusa arvensis. The effectiveness of AgNPs was evaluated for protein kinase inhibition, antioxidant, antibacterial, and antifungal activities. The AgNPs and plant were used to regulate the protein kinase activity using the liquid TSB and ISP4 medium protein kinase inhibition study demonstrated that nanoparticles exhibited a larger zone of inhibition (9.1 ± 0.8) compared to the plant extract (8.1 ± 0.6). The antioxidant activity was assessed using DPPH reagent, and the results indicated that AgNPs displayed potent free radical scavenging properties. In terms of antibacterial activity, AgNPs showed higher efficacy against Enterobacter aerogens (20.1 ± 0.9), Bordetella bronchiseptaca (19.1 ± 0.9), and Salmonella typhimurium (17.2 ± 0.8) at 4 mg/mL. The antifungal activity of AgNPs was prominent against Aspergillus fumagatus (14.1 ± 0.9), Mucor species (19.2 ± 0.8), and Fusarium solani (11.2 ± 0.8) at 20 mg/mL. These findings suggest that AgNPs possess multiple beneficial properties, including bactericidal/fungicidal effects, protein kinase inhibition, and potential free radical scavenging abilities. Therefore, AgNPs have potential applications in various fields, such as biomedicine and industry, due to their ability to counteract the harmful effects of free radicals.
Conceito estrutural de norma jurídica
Authors: Adeodato João Maurício Leitão
Published: September 2024

O texto tem por objetivo sugerir um conceito para um dos termos mais controversos da teoria do direito, que até se confunde com o próprio conceito de direito, qual seja, norma jurídica. Para isso, explicita a estrutura lógica dos enunciados normativos e discute o problema de seus diversos tipos de conectivos, comparando as esferas do ser e do dever ser. Critica os critérios utilizados para diferençar regras de princípios, colocados por parte da doutrina como espécies de normas jurídicas, e analisa a distinção entre normas técnicas e éticas, pois a norma jurídica é tida como parte da ética. Procura aplicar uma metodologia tópica que recusa distinções ontológicas e problematiza oposições.
A superação da affectio societatis como fundamento para exclusão de sócio
Authors: Pimenta Eduardo Goulart
Published: September 2024

O instituto da exclusão de sócio encontra especial aplicação no contexto das sociedades limitadas, tanto no que se refere à quantidade de dispositivos legais sobre o tema quanto se observado o volume de decisões judiciais referentes, de forma direta ou indireta, ao assunto. Isso se explica, em grande parte, pela concepção segundo a qual as sociedades limitadas se pautam, essencialmente, sobre um elemento anímico de harmonia entre os sócios, o qual costuma ser identificado pelo termo affectio societatis. Entretanto, como se busca demonstrar neste texto, a aplicação de consequência severa como a exclusão dos quadros societários não pode se fundar em elemento de tamanha subjetividade e dificuldade de aferição. Nesse sentido, o que se propõe é a superação da affectio societatis como elemento de fundamentação da exclusão de sócio, com sua substituição pela concepção e detalhamento de um dever de colaboração pautado em atos dos partícipes da relação de sociedade.
A fazenda pública e o requerimento de falência
Authors: Magalhães Rodrigo Almeida , Luz Gabriel Gomes da
Published: September 2024

O presente artigo tem por escopo apresentar uma análise conceitual ampla acerca da falência, buscando apresentar aspectos subjetivos, adjetivos e administrativos de tais conceitos e defender a legitimidade da fazenda pública no pedido de falência do empresário/devedor. Para obtenção desses resultados e conclusões utiliza-se a metodologia de pesquisa integrada, analítica, dedutiva e a técnica de pesquisa bibliográfica.
Responsabilidade civil na gestão do arranjo de pagamentos: uma análise à luz do direito consumerista
Authors: Murici Luiz Henrique
Published: September 2024

O artigo investigou se o argumento da segurança tecnológica oferecido pelo cartão com chip é suficiente para afastar a responsabilidade objetiva das instituições financeiras. Para tanto, a pergunta-problema enfrentada foi se o dever de indenizar os danos causados pelas fraudes que ocorrem por meio do uso do cartão com chip é ou não das instituições. O objetivo geral foi estudar a responsabilidade na prestação de serviços que envolvem o arranjo de pagamentos dos cartões de crédito. Como objetivos específicos, fez-se uma releitura doutrinária e jurisprudencial consumeristas sobre o tema, apontou-se indicativos sobre o funcionamento do arranjo de pagamentos dessas instituições e avaliou-se a possibilidade de aprimoramento das decisões judiciais correlatas. O marco teórico se balizou na publicização do direito privado. O estado da arte teve por parâmetro que fraudes que ocorrem nas compras feitas por meio do cartão validado com chip e senha não são responsabilidade das instituições. O estudo é de natureza aplicada. Recortou-se somente as fraudes que envolvem o consumidor e em compras físicas com validação por chip e senha, não tendo sido discutidas aquelas que ocorrem contra o empreendedor. Utilizou-se o método de pesquisa dedutivo, além de ferramentas como levantamento e estudo de bibliografia e jurisprudência, com abordagem qualitativa das informações obtidas.
G-Protein Signaling in Alzheimer's Disease: Spatial Expression Validation of Semi-supervised Deep Learning-Based Computational Framework
Authors: Zhang Daniel F. , Penwell Timothy , Chen Yan-Hua , Koehler Addison , Wu Rui , Nik Akhtar Shayan , Lu Qun
Published: September 2024

Systemic study of pathogenic pathways and interrelationships underlying genes associated with Alzheimer's disease (AD) facilitates the identification of new targets for effective treatments. Recently available large-scale multiomics datasets provide opportunities to use computational approaches for such studies. Here, we devised a novel
di
sease
g
ene
id
entification (digID) computational framework that consists of a semi-supervised deep learning classifier to predict AD-associated genes and a protein–protein interaction (PPI) network-based analysis to prioritize the importance of these predicted genes in AD. digID predicted 1,529 AD-associated genes and revealed potentially new AD molecular mechanisms and therapeutic targets including GNAI1 and GNB1, two G-protein subunits that regulate cell signaling, and KNG1, an upstream modulator of CDC42 small G-protein signaling and mediator of inflammation and candidate coregulator of amyloid precursor protein (APP). Analysis of mRNA expression validated their dysregulation in AD brains but further revealed the significant spatial patterns in different brain regions as well as among different subregions of the frontal cortex and hippocampi. Super-resolution STochastic Optical Reconstruction Microscopy (STORM) further demonstrated their subcellular colocalization and molecular interactions with APP in a transgenic mouse model of both sexes with AD-like mutations. These studies support the predictions made by digID while highlighting the importance of concurrent biological validation of computationally identified gene clusters as potential new AD therapeutic targets.
Social security in flexible forms of employment on the example of Poland - selected problems
Authors:   Institute of Law and Economics, Pedagogical University of Kraków, Poland, Kobroń-Gąsiorowska Łucja
Published: September 2024

The foundation of decent working conditions is the regulation of employment and social policy with safe and secure conditions of employment in terms of remuneration, safe employment conditions, protection in the event of dismissal, social dialogue, personal data protection, and work-life balance, and finally a healthy, safe and a well-adjusted work environment. At the same time, the task of a democratic state is to adjust the dynamically changing economic and market realities to ensure the maximum level of protection in the areas mentioned above relevant to each employee. This state of affairs is also due to the radically progressing digitization, which is changing the challenges of the modern labor market. In this article, the author wants to address the social security problem of selected flexible (atypical) forms of employment, including employee and non-employee forms of employment1. The author chose a fixed-term contract and employment on digital platforms as the subject of the analysis while being aware of the multifaceted nature of social security. In this paper, the author defends the thesis that the so-called and making employment relations are more flexible. Therefore, the legislator should subject these relations to a broader impact - social security regulations, where there are no normative obstacles to extending such influence.
Body composition in recurrent prostate cancer and the role of steroidogenic genotype
Authors: Venkatesh Neha , Tidwell Rebecca S , Yu Yao , Aparicio Ana , Zurita Amado J , Subudhi Sumit K , Siddiqui Bilal A , Mukhida Sagar S , Gregg Justin R , Corn Paul G , Koutroumpakis Efstratios , McQuade Jennifer L , Frigo Daniel E , Pilie Patrick G , Huff Chad , Logothetis Christopher J , Hahn Andrew W
Published: September 2024

Hormone therapy (HT) to treat prostate cancer is reported to cause adverse changes in body composition. Clinically, interpatient body composition changes are heterogeneous, but the biological and clinical determinants of body composition toxicity are unknown. Herein, we test the hypothesis that inherited polymorphisms in steroidogenic genes are associated with differential changes in body composition after HT. Men with biochemically recurrent prostate cancer (BCR) who received 8 months of LHRH analog (LHRHa) +/− abiraterone acetate (AAP) were eligible if they had: i) CT imaging of L3 prior to and after treatment; and ii) nucleated cells collected. Cardiometabolic co-morbidities were retrospectively extracted. Body composition was measured using an AI-based segmentation tool. Germline DNA whole exome or genome sequencing was performed. In 162 men treated with 8 months of HT, median skeletal muscle mass (SMMi) loss was 6.6% and subcutaneous adipose gain was 12.3%. Men with type 2 diabetes had higher losses of SMMi after treatment (−11.1% vs −6.3%, P = 0.003). For the 150 men with germline NGS, SRD5A2 rs523349 genotype was associated with differential loss in skeletal muscle density after HT, (−1.3% vs −7.1%, P = 0.04). In addition, the HSD3B1 rs104703 genotype was associated with decreased baseline visceral adipose tissue (63.0 cm2/m2 vs 77.9, P = 0.05). In men with BCR, HT induced notable loss of skeletal muscle and increased subcutaneous adipose tissue. An inherited polymorphism in SRD5A2 and T2DM was associated with differential skeletal muscle toxicity. These findings suggest that inherited polymorphisms may contribute to the body composition toxicity observed with HT.
Electrocardiographic Evaluation the Effect of Thiamine Hydrochloride on Triton X-100 Induced Hyperlipidemia in Rats
Authors: Ozdemir Murat Taha , Ekici Mehmet
Published: September 2024

Aim: Hyperlipidemia, a prevalent condition globally, contributes significantly to cardiovascular diseases. This research focuses on the impacts of thiamine hydrochloride on lipid profiles and ECG changes in rats with Triton X-100 induced hyperlipidemia. Materials and Methods: A total of eighteen male Wistar Albino rats were divided into three groups: control, Triton X-100, and Triton X-100 + Thiamine. To induce hyperlipidemia, Triton X-100 was administered as a single intraperitoneal dose of 100 mg/kg. Thiamine hydrochloride was then given intraperitoneally at a dose of 25 mg/kg daily for 7 days, starting 72 hours after the induction of hyperlipidemia. ECG data were recorded, and serum biochemical parameters were analyzed. Results: Thiamine treatment significantly reduced elevated total cholesterol and triglyceride levels induced by Triton X-100. It also improved the coronary risk index and normalized ECG characteristics include the heart rate and the RR interval. ECG abnormalities, including ST segment elevation and atrial fibrillation, were less frequent in the thiamine-treated group. Conclusion: Thiamine hydrochloride effectively mitigates hyperlipidemia and its associated cardiovascular risks, suggesting its potential as a therapeutic agent. Further research is needed to explore its clinical applications in managing dyslipidemia and cardiovascular diseases.
The effect of Ag or Au addition on electro- and magnetoresistive properties of Ni80Fe20 thin films
Authors: Lohvynov A.M. , Pazukha I.M. , Pylypenko O.V. , Dolgov-Gordiichuck S.R. , Panchoshnyi O.O. , Khyzhnya Ya.V.
Published: September 2024

The electrophysical and magnetoresistive properties of permalloy Ni80Fe20 (Py) and Py64Ag36 and Py64Au36 thin films prepared by the electron-beam sputtering are presented. The effect of the addition of a third element (Ag or Au) on the resistivity, temperature coefficient of resistivity and magnetoresistance of permalloy films has been described. The structural, electrophysical and magnetoresistive properties of the investigated samples showed a strong dependence on the annealing temperature.
El cambio de precedente en la jurisdicción Contenciosa Administrativa y la modulación de sus efectos en el tiempo, como supuesto de responsabilidad extracontractual del Estado
Authors: Cortés Fajardo María Fernanda , Ferreira Romero María Angélica
Published: September 2024

El presente artículo tiene como objetivo analizar la importancia y necesidad de las reglas de vigencia que deben regir la dinamización de la jurisprudencia para la aplicación del precedente, con el propósito de reconocer y evitar la afectación de los derechos de los ciudadanos en su calidad de sujetos procesales que, en busca de la obtención de justicia y decisiones en Derecho, ajustan sus actuaciones al precedente dominante. Contrario sensu, si estas reglas se desconocen y el operador judicial ignora los derechos involucrados, el resultado, además de traer la nefasta vulneración de derechos, conlleva a la responsabilidad extracontractual del Estado, concretamente de la administración de justicia.
Estructura y formación de la gerencia jurídica empresarial frente a la estructura del área u oficina jurídica actual
Authors: Gutièrrez Ossa Jahir Alexander , Mira Olano Luz Elena , Silva Arroyave Sergio Orlando , Mena Cuesta Milena
Published: September 2024

La reivindicación del carácter gerencial del derecho y la legislación en el ámbito empresarial representa el punto central del artículo. El connato de área, estancia u oficina ha perdido la impronta que se requiere para que las organizaciones marchen. El análisis económico del derecho y el derecho económico, imponen al derecho empresarial o las instancias figuradas amparadas, el incorporar el derecho y la legislación en el marco de la gerencia. En primer lugar, las empresas están en mora de contemplar el marco gerencial de derecho y la legislación en sus organizaciones. En segundo lugar, las externalidades que presentan estas implican una revisión del papel que juega el derecho y la ley, esperando que las empresas atiendan la directiva gerencial de la mano con una incorporación de ellos a la organización. La composición de área u oficina jurídica no ha sido ampliamente eficiente y menos cuando se trata de hacer referencia al marketing jurídico como a cualquier negocio.
Coordination of movements: identification of age-related dynamics of its development in karate boys 7-11 years old
Authors: Marchenko Svitlana , Ivashchenko Olha , Khudolii Oleg , Verygin Vadym
Published: September 2024

The purpose of the study is to identify the age-related dynamics of the manifestation of coordination among junior and pre-pubescent karate boys (7-11 years old) training in the karate section at the initial stage of preparation.

Materials and methods. The study involved 65 children of younger and prepubertal age. They underwent testing of coordination abilities in order to determine the level of development and identify the features of their manifestation in accordance with age and skill level. The selected sample was divided into five ages 7, 8, 9, 10 11 years old, with 13 children in each group. The children and their parents were aware of all the features of the study and gave their consent to participate in the experiment. The technical level of the children corresponded to the students of the 10th, 9th, 8th grades of Kyu (orange, orange with a blue stripe and blue belt color). To solve the tasks, the following research methods were used: study and analysis of scientific and methodological literature, pedagogical observation, timing of educational tasks, testing of coordination abilities, pedagogical ascertaining experiment, methods of mathematical statistics.

Results. One-way analysis of variance (ANOVA) showed a significant effect of the age factor on the level of indicators of coordination abilities for: differentiation of spatial-dynamic parameters of movements (F = 95.712; p = 0.000); reorganization of motor actions (F = 111.410; p = 0.000); differentiation of spatial-temporal parameters (F = 50.863; p = 0.000); coordination of hand movements (F = 96.764; p = 0.000); maintaining postural stability (F = 38.274; p = 0.000); maintaining vestibular stability (F = 61.291; p = 0.000).

Conclusions. Based on the results of studies indicators of various manifestations of coordination, statistically significant age differences are observed between groups of boys aged 7 to 10 years (p < 0.05). At 10-11 years old, there are no significant statistically significant differences in all indicators (p > 0.05), except for dynamic balance (p < 0.05).
Chronic Recurrent Multifocal Osteomyelitis Involving the Spine, Sternum, and Lower Extremities: A Case Report
Authors: Huynh Khanh , McLendon Lane , Woolnough Leandra , Elder Melissa E.
Published: September 2024

Chronic recurrent multifocal osteomyelitis (CRMO) or chronic nonbacterial osteitis is a sterile autoinflammatory disease of bone in children that can mimic infectious osteomyelitis and osteosarcoma. Early diagnosis, treatment, and long-term follow-up of CRMO are essential. We describe a 10-year-old boy who presented with 15 days of left ankle bone more than joint pain, swelling, and limp. Plain radiographs and magnetic resonance imaging scans were nondiagnostic of osteomyelitis and tibial irrigation and biopsy were negative for infection and malignancy. Four years later, he again presented with similar pain in his right ankle. Repeat bone biopsy noted reactive bone changes and bone culture was sterile. Whole-body magnetic resonance imaging revealed multiple enhancing lesions in the long bones of bilateral lower extremities, spine, and sternum. He was diagnosed with CRMO, and treatment with celecoxib and subsequently pamidronate, infliximab, and methotrexate were initiated. After 6 months of treatment, the patient’s gait and pain improved, and 2 years later, his CRMO was in clinical and radiologic remission. Of note, he developed palmoplantar pustular psoriasis, commonly seen in CRMO, that was not determined to be from tumor necrosis factor inhibition.
Ethno-knowledge of family farmers associated with the control of Plutella xylostella L. 1758 (Lepidoptera: Plutellidae) in kale production
Authors: Barreto Marliton Rocha , Yoshio Gemelli Arthur
Published: September 2024

The species Brassica oleracea L. covers the varieties of kale, broccoli, and cabbage, being these crops mainly commercially exploited and cultivated by family farming in Brazil. Over the years, farmers adapt and better understand the problems related to pests and their life cycles, they gain knowledge from their daily work, which becomes important in the decision-making process regarding crops. Plutella xylostella L. is the main pest that attacks crucifers; when poorly controlled, it can compromise the entire production. The objective of this work was to evaluate the ethno-knowledge associated with the control of P. xylostella among family farmers who grow kale. 42 producers were selected by the snowball sampling technique, in the municipalities of Lucas do Rio Verde, Sorriso, and Sinop, Brazil, who answered a semi-structured questionnaire about their social profile, production and ethno-knowledge associated with the control of P. xylostella. It was found that there are several difficulties concerning the production of kale and pest recognition, the production techniques used, and access to information; in many of these factors, technical assistance has contributed to minimizing them through the dissemination of modern and effective techniques. Thus, knowing the role of ethno-knowledge of cabbage producers can contribute to the correct identification of damages in the crop and the pests that causes them, and can prevent the improper use of pesticides by farmers, leading to an efficient control. Furthermore, it can contribute to the valorization of dialogue, the exchange of knowledge and the resolution of problems.
Absorbent materials prepared from wastes derived from banana, rice, and cocoa agro-industries, intended for the capture of hydrocarbons
Authors: Vera Infante Thalía Gabriela , Ferrer Gutiérrez Juan Pedro , Gadvay Yambay Katy Alexandra , Blacio Toro Susana Elizabeth , Cuenca Mayorga Fabián Patricio
Published: September 2024

In this study, adsorbent materials prepared from common wastes generated in agricultural industries were evaluated, particularly the adsorption capacity for hydrocarbon compounds. Wastes from banana, cocoa, and rice were collected, and subsequently dried, milled, and chemically treated with NaOH. The physical properties of the treated wastes were assessed, including buoyancy and apparent density, and their adsorption capacity was tested under dynamic and static conditions. The results were subjected to an analysis of variance (ANOVA). The dynamic adsorption tests carried out indicated that the treated waste from banana leaves with a particle size of 1400 µm exhibited a buoyancy percentage above 90 % in the hydrophilic phase, while hydrocarbon compounds were adsorbed in the oleophilic phase. However, traces of hydrocarbons were still visible in the aqueous medium. In the short-term static adsorption tests, the waste materials showed adsorption capacity values ranging from 2.17 to 8.22 g oil/g adsorbent for motor oil; the highest adsorption index was determined in wastes from banana rachis with an 850 µm particle size. Moreover, in the adsorption of diesel and gasoline, the wastes from banana rachis with an 850 µm particle size showed the highest adsorption capacity for diesel (6.61 g diesel/g adsorbent) and gasoline (6.26 g gasoline/g adsorbent). This behavior was also observed in the long-term tests for all wastes tested, except for banana rachis, as some of the adsorbent material subsided, leading to the adsorption of both water and hydrocarbon compounds.
Effect of planting density and fertilization on yield and tuber characteristics of potato of Group Andigenum
Authors: Vásquez Víctor , Huerta Fernández Pablo , Cabrera Héctor , Jiménez Luis , Pando Rosmeri , Carranza Víctor , Carranza Cristian , Argomedo Betzabé
Published: September 2024

Fertilization and planting density are important practices in potato-producing regions, particularly in regions where yields are not optimal. In addition, appropriate characteristics are required for industrial processing of potato, prompting farmers to improve their productivity and produce varieties demanded by the agroindustrial market. The aim of this study was to determine the effect of two planting densities: 0.20 m x 1.00 m (50,000 plants ha-1) and 0.40 m x 1.00 m (25,000 plans ha-1) and three NPK fertilization doses (60-60-60, 120-120-120, 180-180-180) on the yield and tuber characteristics of potato (Solanum tuberosum Group Andigenum) varieties Serranita, Luyanita, and Capiro. A randomized block design was used with subdivided plots and three replicates. The results indicate higher total yield and commercial yield (42.87 and 38.74 t ha-1) with the 180-180-180 kg ha-1 dose of NPK. The Luyanita variety stood out with yields of 36.03 and 30.97 t ha-1 of total and commercial tuber yield, respectively. The highest total and commercial tuber yields were obtained with the density 0.20 m x 1.00 m. The Luyanita variety showed acceptable physicochemical characteristics for agribusiness with 24.73% dry matter, low content of reducing sugars (0.21%), acceptable color of fries (3.11), specific gravity (1.11 g cm-3) and adequate oil content (20.44%). The planting density factor showed no statistically significant differences.
El giro climático en el planeamiento urbano en Bogotá
Authors: Duque Franco Isabel , Carrillo Loaiza Katerinne , Ramírez Gómez Gustavo
Published: September 2024

Actualmente las ciudades ocupan un lugar central en el debate sobre el cambio climático. Los gobiernos urbanos de todo el mundo están implementando ambiciosos planes para minimizar o responder a los riesgos generados por el cambio climático. Sin embargo, se conoce poco sobre lo que está ocurriendo en las ciudades latinoamericanas. Este trabajo tiene como propósito analizar la experiencia de Bogotá. Con base en la revisión documental y el análisis textual, en el artículo se argumenta que la ciudad está experimentando un giro climático expresado en la inserción y posicionamiento del cambio climático como ámbito del planeamiento urbano. Los resultados indican que dicho giro climático ha sido producto de un proceso relacional en donde han convergido fuerzas tanto exógenas como endógenas y que las medidas de mitigación y adaptación propuestas se mueven entre un repertorio internacional establecido y una cierta dosis de experimentación local.
Handwritten Text Recognition (HTR) for Tibetan Manuscripts in Cursive Script
Authors: Griffiths Rachael M.
Published: September 2024

The use of advanced computational methods for the analysis of digitised texts is becoming increasingly popular in humanities and social science research. One such technology is Handwritten Text Recognition (HTR), which generates transcripts from digitised texts with machine learning approaches, to enable full-text search and analysis. Up to now, HTR models for Tibetan manuscripts in cursive script have not been available. This paper introduces work carried out as part of the The Dawn of Tibetan Buddhist Scholasticism (11th-13th) TibSchol) project at the Austrian Academy of Sciences, which is utilising the Transkribus platform to explore possible solutions to automate the transcription of Tibetan cursive scripts. It presents our methodology and preliminary results along with a discussion of the limitations and potential of our current models.
Participation in Online Social Network Groups as a Driver of Sustainable Behaviour
Authors: Zaborek Piotr , Kurzak-Mabrouk Anna
Published: September 2024

Objective: The study investigates the relationship between engagement in two large English-language online communities on Facebook and Reddit dedicated to sharing green-living tips and promoting sustainable behaviour among their members.
Research Design & Methods: The proposed conceptual framework assumes that the impact of social media engagement on sustainable behaviour change is mediated by intrinsic and extrinsic motives for sustainable behaviour, as well as moderated by homophily (reflecting perceived similarity between an individual and other group members). The model also accounts for time as a social group member and personal characteristics of respondents, including gender, age, income and education. The statistical methods involved structural equation modelling with SmartPLS.
Findings: The findings indicate that participation in online communities leads to favourable changes in attitudes and behavioural patterns. The strength of this association is positively moderated by homophily. Females and research participants who were younger and more affluent reported greater numbers of changes in their behaviour.
Implications / Recommendations: The outcomes of this study can help NGOs, businesses maintaining online brand communities and government policymakers understand how to successfully promote sustainable behaviour through measures aimed at relationship building.
Contribution: This research adds to the theory of marketing communication extending the knowledge about the role of social media in influencing consumer behaviour.
Strengthening Social Responsibility: Ukrainian Universities’ Third Mission Amidst War
Authors:   Ivan Franko National University of Lviv, Stoliaryk Olha , Korniat Vira ,   Ivan Franko National University of Lviv, Hertsyuk Dmytro ,   Ivan Franko National University of Lviv
Published: September 2024

This study explores the challenges and prospects of implementing the Third Mission (TM) of Ukrainian higher education institutions (HEIs) amidst the Russian-Ukrainian conflict. Utilising a qualitative research approach, data were collected from eight Ukrainian HEIs participating in the Erasmus+ project “Community Universities: Strengthening Cooperation”. Findings reveal a lack of legislative clarity regarding TM, hindering its uniform implementation across institutions. Despite this, Ukrainian universities strongly commit to community engagement, with collaborative efforts to address societal needs. The study highlights the urgent need for legislative strengthening of TM and enhanced collaboration with communities to bolster the resilience of HEIs in conflict-affected contexts.
The Case Approach in Cross-Cultural Studies and Projects
Authors:   Warsaw University of Life Science, Poland, Błaszczak Iwona , Loboda Svitlana ,   Warsaw University of Life Science, Poland, Pavlyk Nadiia ,   Zhytomyr Ivan Franko State University, Zhytomyr, Ukraine, Seiko Nataliia ,   Zhytomyr Ivan Franko State University, Zhytomyr, Ukraine, Sytniakivska Svitlana ,   Zhytomyr Ivan Franko State University, Zhytomyr, Ukraine
Published: September 2024

The problem of the study is to substantiate the content of the implementation of the case method of teaching. The article outlines the content of the case method of future bachelor training based on qualitative research. In the example of the academic subject “Cross-cultural studies and projects”, the main steps of developing cross-cultural student projects are traced. The main requirements for creating cross-cultural projects within the distance form of education are defined. The significant result of the study is that the use of teaching methods opens opportunities for students to master the content of professional training.
Passion and Flourishing in University Students: The Moderating and Mediating Roles of Resilience
Authors:   Uniwersytet Marii Curie-Skłodowskiej w Lublinie, Byra Stanisława , Zielińska Patrycja ,   Uniwersytet Marii Curie-Skłodowskiej w Lublinie
Published: September 2024

The presented article analyses the issue of university students’ passion and flourishing in the context of the moderating and mediating role of resilience. Research has shown that passion is related to flourishing, and ego resilience explains this relationship significantly among people with high and average scores. Mediation analysis showed a positive relationship between harmonious passion and resilience coping, consequently affecting flourishing. Thus, higher levels of harmonious passion in students correlate with higher levels of resilient coping, which is associated with greater flourishing. The conclusions suggesting a negative relationship between obsessive passion and flourishing and no relationship with resilience are equally important.