bluuebunny/crossref_metadata_2025 huggingface dataset:
Supplementary Table S2 from Pathobiological Pseudohypoxia as a Putative Mechanism Underlying Myelodysplastic Syndromes
Authors: Hayashi Yoshihiro , Zhang Yue , Yokota Asumi , Yan Xiaomei , Liu Jinqin , Choi Kwangmin , Li Bing , Sashida Goro , Peng Yanyan , Xu Zefeng , Huang Rui , Zhang Lulu , Freudiger George M. , Wang Jingya , Dong Yunzhu , Zhou Yile , Wang Jieyu , Wu Lingyun , Bu Jiachen , Chen Aili , Zhao Xinghui , Sun Xiujuan , Chetal Kashish , Olsson Andre , Watanabe Miki , Romick-Rosendale Lindsey E. , Harada Hironori , Shih Lee-Yung , Tse William , Bridges James P. , Caligiuri Michael A. , Huang Taosheng , Zheng Yi , Witte David P. , Wang Qian-fei , Qu Cheng-Kui , Salomonis Nathan , Grimes H. Leighton , Nimer Stephen D. , Xiao Zhijian , Huang Gang
Published: April 2023

Table S2
Supplementary Methods from Pathobiological Pseudohypoxia as a Putative Mechanism Underlying Myelodysplastic Syndromes
Authors: Hayashi Yoshihiro , Zhang Yue , Yokota Asumi , Yan Xiaomei , Liu Jinqin , Choi Kwangmin , Li Bing , Sashida Goro , Peng Yanyan , Xu Zefeng , Huang Rui , Zhang Lulu , Freudiger George M. , Wang Jingya , Dong Yunzhu , Zhou Yile , Wang Jieyu , Wu Lingyun , Bu Jiachen , Chen Aili , Zhao Xinghui , Sun Xiujuan , Chetal Kashish , Olsson Andre , Watanabe Miki , Romick-Rosendale Lindsey E. , Harada Hironori , Shih Lee-Yung , Tse William , Bridges James P. , Caligiuri Michael A. , Huang Taosheng , Zheng Yi , Witte David P. , Wang Qian-fei , Qu Cheng-Kui , Salomonis Nathan , Grimes H. Leighton , Nimer Stephen D. , Xiao Zhijian , Huang Gang
Published: April 2023

Supplementary Methods
Supplementary Figure Legends from Identification of a DNA Damage–Induced Alternative Splicing Pathway That Regulates p53 and Cellular Senescence Markers
Authors: Chen Jing , Crutchley John , Zhang Dadong , Owzar Kouros , Kastan Michael B.
Published: April 2023

Supplementary figure legends
Supplementary Table S4 from Chemotherapy-Resistant Human Acute Myeloid Leukemia Cells Are Not Enriched for Leukemic Stem Cells but Require Oxidative Metabolism
Authors: Farge Thomas , Saland Estelle , de Toni Fabienne , Aroua Nesrine , Hosseini Mohsen , Perry Robin , Bosc Claudie , Sugita Mayumi , Stuani Lucille , Fraisse Marine , Scotland Sarah , Larrue Clément , Boutzen Héléna , Féliu Virginie , Nicolau-Travers Marie-Laure , Cassant-Sourdy Stéphanie , Broin Nicolas , David Marion , Serhan Nizar , Sarry Audrey , Tavitian Suzanne , Kaoma Tony , Vallar Laurent , Iacovoni Jason , Linares Laetitia K. , Montersino Camille , Castellano Rémy , Griessinger Emmanuel , Collette Yves , Duchamp Olivier , Barreira Yara , Hirsch Pierre , Palama Tony , Gales Lara , Delhommeau François , Garmy-Susini Barbara H. , Portais Jean-Charles , Vergez François , Selak Mary , Danet-Desnoyers Gwenn , Carroll Martin , Récher Christian , Sarry Jean-Emmanuel
Published: April 2023

(1) HIGH OXPHOS gene signature generated from HIGH versus LOW OXPHOS AML cell lines untreated or treated with metformin. (2) Functional analysis of upregulated genes encoding for mitochondrial proteins in untreated HIGH versus LOW OXPHOS AML cell lines.
Supplementary Table S3 from Chemotherapy-Resistant Human Acute Myeloid Leukemia Cells Are Not Enriched for Leukemic Stem Cells but Require Oxidative Metabolism
Authors: Farge Thomas , Saland Estelle , de Toni Fabienne , Aroua Nesrine , Hosseini Mohsen , Perry Robin , Bosc Claudie , Sugita Mayumi , Stuani Lucille , Fraisse Marine , Scotland Sarah , Larrue Clément , Boutzen Héléna , Féliu Virginie , Nicolau-Travers Marie-Laure , Cassant-Sourdy Stéphanie , Broin Nicolas , David Marion , Serhan Nizar , Sarry Audrey , Tavitian Suzanne , Kaoma Tony , Vallar Laurent , Iacovoni Jason , Linares Laetitia K. , Montersino Camille , Castellano Rémy , Griessinger Emmanuel , Collette Yves , Duchamp Olivier , Barreira Yara , Hirsch Pierre , Palama Tony , Gales Lara , Delhommeau François , Garmy-Susini Barbara H. , Portais Jean-Charles , Vergez François , Selak Mary , Danet-Desnoyers Gwenn , Carroll Martin , Récher Christian , Sarry Jean-Emmanuel
Published: April 2023

(1) Gene signatures of AraC residual AML blasts in vivo from three AML patients xenografted and treated with AraC. (2) Functional analyses of up-regulated genes of AraC residual AML blasts in vivo. (3) Functional analyses of down-regulated genes of AraC residual AML blasts in vivo. (4) Prognostic analysis of the up- and down- regulated gene signatures of AraC-residual AML blasts in vivo in three independently published cohorts of AML patients.
Supplementary Table S2 from Chemotherapy-Resistant Human Acute Myeloid Leukemia Cells Are Not Enriched for Leukemic Stem Cells but Require Oxidative Metabolism
Authors: Farge Thomas , Saland Estelle , de Toni Fabienne , Aroua Nesrine , Hosseini Mohsen , Perry Robin , Bosc Claudie , Sugita Mayumi , Stuani Lucille , Fraisse Marine , Scotland Sarah , Larrue Clément , Boutzen Héléna , Féliu Virginie , Nicolau-Travers Marie-Laure , Cassant-Sourdy Stéphanie , Broin Nicolas , David Marion , Serhan Nizar , Sarry Audrey , Tavitian Suzanne , Kaoma Tony , Vallar Laurent , Iacovoni Jason , Linares Laetitia K. , Montersino Camille , Castellano Rémy , Griessinger Emmanuel , Collette Yves , Duchamp Olivier , Barreira Yara , Hirsch Pierre , Palama Tony , Gales Lara , Delhommeau François , Garmy-Susini Barbara H. , Portais Jean-Charles , Vergez François , Selak Mary , Danet-Desnoyers Gwenn , Carroll Martin , Récher Christian , Sarry Jean-Emmanuel
Published: April 2023

Determination of LICs frequency in bone marrow and spleen from AraC- or PBS-treated AML-xenografted NSG mice using in vivo limiting dilution assay.
Supplementary Figure 6 from AZD9291, an Irreversible EGFR TKI, Overcomes T790M-Mediated Resistance to EGFR Inhibitors in Lung Cancer
Authors: Cross Darren A.E. , Ashton Susan E. , Ghiorghiu Serban , Eberlein Cath , Nebhan Caroline A. , Spitzler Paula J. , Orme Jonathon P. , Finlay M. Raymond V. , Ward Richard A. , Mellor Martine J. , Hughes Gareth , Rahi Amar , Jacobs Vivien N. , Brewer Monica Red , Ichihara Eiki , Sun Jing , Jin Hailing , Ballard Peter , Al-Kadhimi Katherine , Rowlinson Rachel , Klinowska Teresa , Richmond Graham H.P. , Cantarini Mireille , Kim Dong-Wan , Ranson Malcolm R. , Pao William
Published: April 2023

PDF file - 312KB, Efficacy of AZD9291 in H3255, PC-9VanR and A431 xenograft models. Weight loss data for chronically dosed AZD9291 in PC-9 and H1975 xenograft models.
Supplementary Figure 4 from AZD9291, an Irreversible EGFR TKI, Overcomes T790M-Mediated Resistance to EGFR Inhibitors in Lung Cancer
Authors: Cross Darren A.E. , Ashton Susan E. , Ghiorghiu Serban , Eberlein Cath , Nebhan Caroline A. , Spitzler Paula J. , Orme Jonathon P. , Finlay M. Raymond V. , Ward Richard A. , Mellor Martine J. , Hughes Gareth , Rahi Amar , Jacobs Vivien N. , Brewer Monica Red , Ichihara Eiki , Sun Jing , Jin Hailing , Ballard Peter , Al-Kadhimi Katherine , Rowlinson Rachel , Klinowska Teresa , Richmond Graham H.P. , Cantarini Mireille , Kim Dong-Wan , Ranson Malcolm R. , Pao William
Published: April 2023

PDF file - 294KB, Phenotype and phosphorylation assay data for AZD9291 against lung cancer associated HER2 mutation.
Supplementary Figure 3 from AZD9291, an Irreversible EGFR TKI, Overcomes T790M-Mediated Resistance to EGFR Inhibitors in Lung Cancer
Authors: Cross Darren A.E. , Ashton Susan E. , Ghiorghiu Serban , Eberlein Cath , Nebhan Caroline A. , Spitzler Paula J. , Orme Jonathon P. , Finlay M. Raymond V. , Ward Richard A. , Mellor Martine J. , Hughes Gareth , Rahi Amar , Jacobs Vivien N. , Brewer Monica Red , Ichihara Eiki , Sun Jing , Jin Hailing , Ballard Peter , Al-Kadhimi Katherine , Rowlinson Rachel , Klinowska Teresa , Richmond Graham H.P. , Cantarini Mireille , Kim Dong-Wan , Ranson Malcolm R. , Pao William
Published: April 2023

PDF file - 235KB, Activity of AZD9291 and metabolites against rare EGFR mutations using cellular phosphorylation assays.
Supplementary Tables 4 - 9 from Deconstruction of a Metastatic Tumor Microenvironment Reveals a Common Matrix Response in Human Cancers
Authors: Pearce Oliver M.T. , Delaine-Smith Robin M. , Maniati Eleni , Nichols Sam , Wang Jun , Böhm Steffen , Rajeeve Vinothini , Ullah Dayem , Chakravarty Probir , Jones Roanne R. , Montfort Anne , Dowe Tom , Gribben John , Jones J. Louise , Kocher Hemant M. , Serody Jonathan S. , Vincent Benjamin G. , Connelly John , Brenton James D. , Chelala Claude , Cutillas Pedro R. , Lockley Michelle , Bessant Conrad , Knight Martin M. , Balkwill Frances R.
Published: April 2023

Supplementary Tables 4 - 9
Supplementary Tables 15 - 25 from Deconstruction of a Metastatic Tumor Microenvironment Reveals a Common Matrix Response in Human Cancers
Authors: Pearce Oliver M.T. , Delaine-Smith Robin M. , Maniati Eleni , Nichols Sam , Wang Jun , Böhm Steffen , Rajeeve Vinothini , Ullah Dayem , Chakravarty Probir , Jones Roanne R. , Montfort Anne , Dowe Tom , Gribben John , Jones J. Louise , Kocher Hemant M. , Serody Jonathan S. , Vincent Benjamin G. , Connelly John , Brenton James D. , Chelala Claude , Cutillas Pedro R. , Lockley Michelle , Bessant Conrad , Knight Martin M. , Balkwill Frances R.
Published: April 2023

Supplementary Tables 15 - 25
Supplementary Tables 1 - 3 from Deconstruction of a Metastatic Tumor Microenvironment Reveals a Common Matrix Response in Human Cancers
Authors: Pearce Oliver M.T. , Delaine-Smith Robin M. , Maniati Eleni , Nichols Sam , Wang Jun , Böhm Steffen , Rajeeve Vinothini , Ullah Dayem , Chakravarty Probir , Jones Roanne R. , Montfort Anne , Dowe Tom , Gribben John , Jones J. Louise , Kocher Hemant M. , Serody Jonathan S. , Vincent Benjamin G. , Connelly John , Brenton James D. , Chelala Claude , Cutillas Pedro R. , Lockley Michelle , Bessant Conrad , Knight Martin M. , Balkwill Frances R.
Published: April 2023

Supplementary Tables 1 - 3
Supplemental Figures S1-S11 from TCR Repertoire Intratumor Heterogeneity in Localized Lung Adenocarcinomas: An Association with Predicted Neoantigen Heterogeneity and Postsurgical Recurrence
Authors: Reuben Alexandre , Gittelman Rachel , Gao Jianjun , Zhang Jiexin , Yusko Erik C. , Wu Chang-Jiun , Emerson Ryan , Zhang Jianhua , Tipton Christopher , Li Jun , Quek Kelly , Gopalakrishnan Vancheswaran , Chen Runzhe , Vence Luis M. , Cascone Tina , Vignali Marissa , Fujimoto Junya , Rodriguez-Canales Jaime , Parra Edwin R. , Little Latasha D. , Gumbs Curtis , Forget Marie-Andrée , Federico Lorenzo , Haymaker Cara , Behrens Carmen , Benzeno Sharon , Bernatchez Chantale , Sepesi Boris , Gibbons Don L. , Wargo Jennifer A. , William William N. , Swisher Stephen , Heymach John V. , Robins Harlan , Lee J. Jack , Sharma Padmanee , Allison James P. , Futreal P. Andrew , Wistuba Ignacio I. , Zhang Jianjun
Published: April 2023

Supplemental Figure S1. Number of predicted neoantigens. Supplemental Figure S2. Association between expressed branch predicted neoantigens and relapse. Supplemental Figure S3. Substantial ITH in the number of unique T cell rearrangements. Supplemental Figure S4. Substantial ITH in tumor-enriched T cell repertoire in 8 patients whose blood samples were available. Supplemental Figure S5. A minority of T cell clones are shared between different regions within a tumor. Supplemental Figure S6. The top 5 clones within each tumor are conserved across all regions of that given tumor. Supplemental Figure S7. Tumor-enriched MOI in patients with available paired blood. Supplemental Figure S8. CD4-dominant T cell infiltrate in localized lung adenocarcinomas by immunohistochemical (IHC) staining. Supplemental Figure S9. Correlation between predicted neoantigen burden and TCR metrics. Supplemental Figure S10. Association between intratumor TCR heterogeneity and patient relapse. Supplemental Figure S11. Follow up time (months) in patients who recurred and those who have not. n.s., not significant.
Supplemental Figure Legends from TCR Repertoire Intratumor Heterogeneity in Localized Lung Adenocarcinomas: An Association with Predicted Neoantigen Heterogeneity and Postsurgical Recurrence
Authors: Reuben Alexandre , Gittelman Rachel , Gao Jianjun , Zhang Jiexin , Yusko Erik C. , Wu Chang-Jiun , Emerson Ryan , Zhang Jianhua , Tipton Christopher , Li Jun , Quek Kelly , Gopalakrishnan Vancheswaran , Chen Runzhe , Vence Luis M. , Cascone Tina , Vignali Marissa , Fujimoto Junya , Rodriguez-Canales Jaime , Parra Edwin R. , Little Latasha D. , Gumbs Curtis , Forget Marie-Andrée , Federico Lorenzo , Haymaker Cara , Behrens Carmen , Benzeno Sharon , Bernatchez Chantale , Sepesi Boris , Gibbons Don L. , Wargo Jennifer A. , William William N. , Swisher Stephen , Heymach John V. , Robins Harlan , Lee J. Jack , Sharma Padmanee , Allison James P. , Futreal P. Andrew , Wistuba Ignacio I. , Zhang Jianjun
Published: April 2023

Supplemental Figure Legends
Supplementary Figure S1 from Modeling Renal Cell Carcinoma in Mice: Bap1 and Pbrm1 Inactivation Drive Tumor Grade
Authors: Gu Yi-Feng , Cohn Shannon , Christie Alana , McKenzie Tiffani , Wolff Nicholas , Do Quyen N. , Madhuranthakam Ananth J. , Pedrosa Ivan , Wang Tao , Dey Anwesha , Busslinger Meinrad , Xie Xian-Jin , Hammer Robert E. , McKay Renée M. , Kapur Payal , Brugarolas James
Published: April 2023

Validation of Pax8-Cre;Vhl;Bap1 mice.
Supplementary Figure Legends from Modeling Renal Cell Carcinoma in Mice: Bap1 and Pbrm1 Inactivation Drive Tumor Grade
Authors: Gu Yi-Feng , Cohn Shannon , Christie Alana , McKenzie Tiffani , Wolff Nicholas , Do Quyen N. , Madhuranthakam Ananth J. , Pedrosa Ivan , Wang Tao , Dey Anwesha , Busslinger Meinrad , Xie Xian-Jin , Hammer Robert E. , McKay Renée M. , Kapur Payal , Brugarolas James
Published: April 2023

Supplementary Figure Legends
Supplementary Figure Legends from EGFR and MET Amplifications Determine Response to HER2 Inhibition in ERBB2-Amplified Esophagogastric Cancer
Authors: Sanchez-Vega Francisco , Hechtman Jaclyn F. , Castel Pau , Ku Geoffrey Y. , Tuvy Yaelle , Won Helen , Fong Christopher J. , Bouvier Nancy , Nanjangud Gouri J. , Soong Joanne , Vakiani Efsevia , Schattner Mark , Kelsen David P. , Lefkowitz Robert A. , Brown Karen , Lacouture Mario E. , Capanu Marinela , Mattar Marissa , Qeriqi Besnik , Cecchi Fabiola , Tian Yuan , Hembrough Todd , Nagy Rebecca J. , Lanman Richard B. , Larson Steven M. , Pandit-Taskar Neeta , Schöder Heiko , Iacobuzio-Donahue Christine A. , Ilson David H. , Weber Wolfgang A. , Berger Michael F. , de Stanchina Elisa , Taylor Barry S. , Lewis Jason S. , Solit David B. , Carrasquillo Jorge A. , Scaltriti Maurizio , Schultz Nikolaus , Janjigian Yelena Y.
Published: April 2023

Supplementary Figure Legends
Figure S2 from EGFR and MET Amplifications Determine Response to HER2 Inhibition in ERBB2-Amplified Esophagogastric Cancer
Authors: Sanchez-Vega Francisco , Hechtman Jaclyn F. , Castel Pau , Ku Geoffrey Y. , Tuvy Yaelle , Won Helen , Fong Christopher J. , Bouvier Nancy , Nanjangud Gouri J. , Soong Joanne , Vakiani Efsevia , Schattner Mark , Kelsen David P. , Lefkowitz Robert A. , Brown Karen , Lacouture Mario E. , Capanu Marinela , Mattar Marissa , Qeriqi Besnik , Cecchi Fabiola , Tian Yuan , Hembrough Todd , Nagy Rebecca J. , Lanman Richard B. , Larson Steven M. , Pandit-Taskar Neeta , Schöder Heiko , Iacobuzio-Donahue Christine A. , Ilson David H. , Weber Wolfgang A. , Berger Michael F. , de Stanchina Elisa , Taylor Barry S. , Lewis Jason S. , Solit David B. , Carrasquillo Jorge A. , Scaltriti Maurizio , Schultz Nikolaus , Janjigian Yelena Y.
Published: April 2023

CONSORT diagram
Figure S1 from EGFR and MET Amplifications Determine Response to HER2 Inhibition in ERBB2-Amplified Esophagogastric Cancer
Authors: Sanchez-Vega Francisco , Hechtman Jaclyn F. , Castel Pau , Ku Geoffrey Y. , Tuvy Yaelle , Won Helen , Fong Christopher J. , Bouvier Nancy , Nanjangud Gouri J. , Soong Joanne , Vakiani Efsevia , Schattner Mark , Kelsen David P. , Lefkowitz Robert A. , Brown Karen , Lacouture Mario E. , Capanu Marinela , Mattar Marissa , Qeriqi Besnik , Cecchi Fabiola , Tian Yuan , Hembrough Todd , Nagy Rebecca J. , Lanman Richard B. , Larson Steven M. , Pandit-Taskar Neeta , Schöder Heiko , Iacobuzio-Donahue Christine A. , Ilson David H. , Weber Wolfgang A. , Berger Michael F. , de Stanchina Elisa , Taylor Barry S. , Lewis Jason S. , Solit David B. , Carrasquillo Jorge A. , Scaltriti Maurizio , Schultz Nikolaus , Janjigian Yelena Y.
Published: April 2023

Additional results for dual probe EGFR and ERBB2 FISH from Patients 9, 30 and 32.
Supplementary tables from ER Translocation of the MAPK Pathway Drives Therapy Resistance in BRAF-Mutant Melanoma
Authors: Ojha Rani , Leli Nektaria M. , Onorati Angelique , Piao Shengfu , Verginadis Ioannis I. , Tameire Feven , Rebecca Vito W. , Chude Cynthia I. , Murugan Sengottuvelan , Fennelly Colin , Noguera-Ortega Estela , Chu Charleen T. , Liu Shujing , Xu Xiaowei , Krepler Clemens , Xiao Min , Xu Wei , Wei Zhi , Frederick Dennie T. , Boland Genevieve , Mitchell Tara C. , Karakousis Giorgos C. , Schuchter Lynn M. , Flaherty Keith T. , Zhang Gao , Herlyn Meenhard , Koumenis Constantinos , Amaravadi Ravi K.
Published: April 2023

Supplementary tables S1-8
Supplementary Figures from ER Translocation of the MAPK Pathway Drives Therapy Resistance in BRAF-Mutant Melanoma
Authors: Ojha Rani , Leli Nektaria M. , Onorati Angelique , Piao Shengfu , Verginadis Ioannis I. , Tameire Feven , Rebecca Vito W. , Chude Cynthia I. , Murugan Sengottuvelan , Fennelly Colin , Noguera-Ortega Estela , Chu Charleen T. , Liu Shujing , Xu Xiaowei , Krepler Clemens , Xiao Min , Xu Wei , Wei Zhi , Frederick Dennie T. , Boland Genevieve , Mitchell Tara C. , Karakousis Giorgos C. , Schuchter Lynn M. , Flaherty Keith T. , Zhang Gao , Herlyn Meenhard , Koumenis Constantinos , Amaravadi Ravi K.
Published: April 2023

Supplementary Figures 1-11
Tables S3-S4 from Discovery of Selective Estrogen Receptor Covalent Antagonists for the Treatment of ERαWT and ERαMUT Breast Cancer
Authors: Puyang Xiaoling , Furman Craig , Zheng Guo Zhu , Wu Zhenhua J. , Banka Deepti , Aithal Kiran , Agoulnik Sergei , Bolduc David M. , Buonamici Silvia , Caleb Benjamin , Das Subhasree , Eckley Sean , Fekkes Peter , Hao Ming-Hong , Hart Andrew , Houtman René , Irwin Sean , Joshi Jaya J. , Karr Craig , Kim Amy , Kumar Namita , Kumar Pavan , Kuznetsov Galina , Lai Weidong G. , Larsen Nicholas , Mackenzie Crystal , Martin Lesley-Ann , Melchers Diana , Moriarty Alyssa , Nguyen Tuong-Vi , Norris John , O'Shea Morgan , Pancholi Sunil , Prajapati Sudeep , Rajagopalan Sujatha , Reynolds Dominic J. , Rimkunas Victoria , Rioux Nathalie , Ribas Ricardo , Siu Amy , Sivakumar Sasirekha , Subramanian Vanitha , Thomas Michael , Vaillancourt Frédéric H. , Wang John , Wardell Suzanne , Wick Michael J. , Yao Shihua , Yu Lihua , Warmuth Markus , Smith Peter G. , Zhu Ping , Korpal Manav
Published: April 2023

Enriched GSEA pathways
Tables S1-S2 from Discovery of Selective Estrogen Receptor Covalent Antagonists for the Treatment of ERαWT and ERαMUT Breast Cancer
Authors: Puyang Xiaoling , Furman Craig , Zheng Guo Zhu , Wu Zhenhua J. , Banka Deepti , Aithal Kiran , Agoulnik Sergei , Bolduc David M. , Buonamici Silvia , Caleb Benjamin , Das Subhasree , Eckley Sean , Fekkes Peter , Hao Ming-Hong , Hart Andrew , Houtman René , Irwin Sean , Joshi Jaya J. , Karr Craig , Kim Amy , Kumar Namita , Kumar Pavan , Kuznetsov Galina , Lai Weidong G. , Larsen Nicholas , Mackenzie Crystal , Martin Lesley-Ann , Melchers Diana , Moriarty Alyssa , Nguyen Tuong-Vi , Norris John , O'Shea Morgan , Pancholi Sunil , Prajapati Sudeep , Rajagopalan Sujatha , Reynolds Dominic J. , Rimkunas Victoria , Rioux Nathalie , Ribas Ricardo , Siu Amy , Sivakumar Sasirekha , Subramanian Vanitha , Thomas Michael , Vaillancourt Frédéric H. , Wang John , Wardell Suzanne , Wick Michael J. , Yao Shihua , Yu Lihua , Warmuth Markus , Smith Peter G. , Zhu Ping , Korpal Manav
Published: April 2023

Crystallography and amino acid coordinates
Supplementary Table S5 from EIF1AX and RAS Mutations Cooperate to Drive Thyroid Tumorigenesis through ATF4 and c-MYC
Authors: Krishnamoorthy Gnana P. , Davidson Natalie R. , Leach Steven D. , Zhao Zhen , Lowe Scott W. , Lee Gina , Landa Iňigo , Nagarajah James , Saqcena Mahesh , Singh Kamini , Wendel Hans-Guido , Dogan Snjezana , Tamarapu Prasanna P. , Blenis John , Ghossein Ronald A. , Knauf Jeffrey A. , Rätsch Gunnar , Fagin James A.
Published: April 2023

List of Oligonucleotides used.
Supplementary Methods from Discovery of Selective Estrogen Receptor Covalent Antagonists for the Treatment of ERαWT and ERαMUT Breast Cancer
Authors: Puyang Xiaoling , Furman Craig , Zheng Guo Zhu , Wu Zhenhua J. , Banka Deepti , Aithal Kiran , Agoulnik Sergei , Bolduc David M. , Buonamici Silvia , Caleb Benjamin , Das Subhasree , Eckley Sean , Fekkes Peter , Hao Ming-Hong , Hart Andrew , Houtman René , Irwin Sean , Joshi Jaya J. , Karr Craig , Kim Amy , Kumar Namita , Kumar Pavan , Kuznetsov Galina , Lai Weidong G. , Larsen Nicholas , Mackenzie Crystal , Martin Lesley-Ann , Melchers Diana , Moriarty Alyssa , Nguyen Tuong-Vi , Norris John , O'Shea Morgan , Pancholi Sunil , Prajapati Sudeep , Rajagopalan Sujatha , Reynolds Dominic J. , Rimkunas Victoria , Rioux Nathalie , Ribas Ricardo , Siu Amy , Sivakumar Sasirekha , Subramanian Vanitha , Thomas Michael , Vaillancourt Frédéric H. , Wang John , Wardell Suzanne , Wick Michael J. , Yao Shihua , Yu Lihua , Warmuth Markus , Smith Peter G. , Zhu Ping , Korpal Manav
Published: April 2023

Additional methods provided.
Supplementary Table S4 from EIF1AX and RAS Mutations Cooperate to Drive Thyroid Tumorigenesis through ATF4 and c-MYC
Authors: Krishnamoorthy Gnana P. , Davidson Natalie R. , Leach Steven D. , Zhao Zhen , Lowe Scott W. , Lee Gina , Landa Iňigo , Nagarajah James , Saqcena Mahesh , Singh Kamini , Wendel Hans-Guido , Dogan Snjezana , Tamarapu Prasanna P. , Blenis John , Ghossein Ronald A. , Knauf Jeffrey A. , Rätsch Gunnar , Fagin James A.
Published: April 2023

Positively enriched gene signatures by GSEA using using MsigDB-HALLMARKS and CANONICAL PATHWAYS genesets in C643 vs C643-spl-rev cells.
Supplementary Table S3 from EIF1AX and RAS Mutations Cooperate to Drive Thyroid Tumorigenesis through ATF4 and c-MYC
Authors: Krishnamoorthy Gnana P. , Davidson Natalie R. , Leach Steven D. , Zhao Zhen , Lowe Scott W. , Lee Gina , Landa Iňigo , Nagarajah James , Saqcena Mahesh , Singh Kamini , Wendel Hans-Guido , Dogan Snjezana , Tamarapu Prasanna P. , Blenis John , Ghossein Ronald A. , Knauf Jeffrey A. , Rätsch Gunnar , Fagin James A.
Published: April 2023

Positively enriched gene signatures by GSEA using MsigDB-HALLMARKS and CANONICAL PATHWAYS genesets in CAL62-splice vs CAL62 cells.
Figures S20-S23 from Discovery of Selective Estrogen Receptor Covalent Antagonists for the Treatment of ERαWT and ERαMUT Breast Cancer
Authors: Puyang Xiaoling , Furman Craig , Zheng Guo Zhu , Wu Zhenhua J. , Banka Deepti , Aithal Kiran , Agoulnik Sergei , Bolduc David M. , Buonamici Silvia , Caleb Benjamin , Das Subhasree , Eckley Sean , Fekkes Peter , Hao Ming-Hong , Hart Andrew , Houtman René , Irwin Sean , Joshi Jaya J. , Karr Craig , Kim Amy , Kumar Namita , Kumar Pavan , Kuznetsov Galina , Lai Weidong G. , Larsen Nicholas , Mackenzie Crystal , Martin Lesley-Ann , Melchers Diana , Moriarty Alyssa , Nguyen Tuong-Vi , Norris John , O'Shea Morgan , Pancholi Sunil , Prajapati Sudeep , Rajagopalan Sujatha , Reynolds Dominic J. , Rimkunas Victoria , Rioux Nathalie , Ribas Ricardo , Siu Amy , Sivakumar Sasirekha , Subramanian Vanitha , Thomas Michael , Vaillancourt Frédéric H. , Wang John , Wardell Suzanne , Wick Michael J. , Yao Shihua , Yu Lihua , Warmuth Markus , Smith Peter G. , Zhu Ping , Korpal Manav
Published: April 2023

H3B-5942 in combination with palbocyclib shows synergy in vitro and in vivo
Supplementary Table S2 from EIF1AX and RAS Mutations Cooperate to Drive Thyroid Tumorigenesis through ATF4 and c-MYC
Authors: Krishnamoorthy Gnana P. , Davidson Natalie R. , Leach Steven D. , Zhao Zhen , Lowe Scott W. , Lee Gina , Landa Iňigo , Nagarajah James , Saqcena Mahesh , Singh Kamini , Wendel Hans-Guido , Dogan Snjezana , Tamarapu Prasanna P. , Blenis John , Ghossein Ronald A. , Knauf Jeffrey A. , Rätsch Gunnar , Fagin James A.
Published: April 2023

List of genes translated with lower efficiency (TE-down) in C643 vs C643-spl-rev cells by ribosome profiling.
Figures S13-S19 from Discovery of Selective Estrogen Receptor Covalent Antagonists for the Treatment of ERαWT and ERαMUT Breast Cancer
Authors: Puyang Xiaoling , Furman Craig , Zheng Guo Zhu , Wu Zhenhua J. , Banka Deepti , Aithal Kiran , Agoulnik Sergei , Bolduc David M. , Buonamici Silvia , Caleb Benjamin , Das Subhasree , Eckley Sean , Fekkes Peter , Hao Ming-Hong , Hart Andrew , Houtman René , Irwin Sean , Joshi Jaya J. , Karr Craig , Kim Amy , Kumar Namita , Kumar Pavan , Kuznetsov Galina , Lai Weidong G. , Larsen Nicholas , Mackenzie Crystal , Martin Lesley-Ann , Melchers Diana , Moriarty Alyssa , Nguyen Tuong-Vi , Norris John , O'Shea Morgan , Pancholi Sunil , Prajapati Sudeep , Rajagopalan Sujatha , Reynolds Dominic J. , Rimkunas Victoria , Rioux Nathalie , Ribas Ricardo , Siu Amy , Sivakumar Sasirekha , Subramanian Vanitha , Thomas Michael , Vaillancourt Frédéric H. , Wang John , Wardell Suzanne , Wick Michael J. , Yao Shihua , Yu Lihua , Warmuth Markus , Smith Peter G. , Zhu Ping , Korpal Manav
Published: April 2023

H3B-5942 exhibits dose-dependent inhibition of ER target genes and shows significant efficacy ER Wt and mutant in vivo models
Supplementary Table S1 from EIF1AX and RAS Mutations Cooperate to Drive Thyroid Tumorigenesis through ATF4 and c-MYC
Authors: Krishnamoorthy Gnana P. , Davidson Natalie R. , Leach Steven D. , Zhao Zhen , Lowe Scott W. , Lee Gina , Landa Iňigo , Nagarajah James , Saqcena Mahesh , Singh Kamini , Wendel Hans-Guido , Dogan Snjezana , Tamarapu Prasanna P. , Blenis John , Ghossein Ronald A. , Knauf Jeffrey A. , Rätsch Gunnar , Fagin James A.
Published: April 2023

List of genes efficiently translated (TE-up) in C643 vs C643-spl-rev cells by ribosome profiling.
Figures S1-S6 from Discovery of Selective Estrogen Receptor Covalent Antagonists for the Treatment of ERαWT and ERαMUT Breast Cancer
Authors: Puyang Xiaoling , Furman Craig , Zheng Guo Zhu , Wu Zhenhua J. , Banka Deepti , Aithal Kiran , Agoulnik Sergei , Bolduc David M. , Buonamici Silvia , Caleb Benjamin , Das Subhasree , Eckley Sean , Fekkes Peter , Hao Ming-Hong , Hart Andrew , Houtman René , Irwin Sean , Joshi Jaya J. , Karr Craig , Kim Amy , Kumar Namita , Kumar Pavan , Kuznetsov Galina , Lai Weidong G. , Larsen Nicholas , Mackenzie Crystal , Martin Lesley-Ann , Melchers Diana , Moriarty Alyssa , Nguyen Tuong-Vi , Norris John , O'Shea Morgan , Pancholi Sunil , Prajapati Sudeep , Rajagopalan Sujatha , Reynolds Dominic J. , Rimkunas Victoria , Rioux Nathalie , Ribas Ricardo , Siu Amy , Sivakumar Sasirekha , Subramanian Vanitha , Thomas Michael , Vaillancourt Frédéric H. , Wang John , Wardell Suzanne , Wick Michael J. , Yao Shihua , Yu Lihua , Warmuth Markus , Smith Peter G. , Zhu Ping , Korpal Manav
Published: April 2023

ESR1 mutants are resistant to endocrine therapies in vitro and in vivo and H3B-5942 can suppress ER pathway activity.
Supplementary Methods from BRD4 Profiling Identifies Critical Chronic Lymphocytic Leukemia Oncogenic Circuits and Reveals Sensitivity to PLX51107, a Novel Structurally Distinct BET Inhibitor
Authors: Ozer Hatice Gulcin , El-Gamal Dalia , Powell Ben , Hing Zachary A. , Blachly James S. , Harrington Bonnie , Mitchell Shaneice , Grieselhuber Nicole R. , Williams Katie , Lai Tzung-Huei , Alinari Lapo , Baiocchi Robert A. , Brinton Lindsey , Baskin Elizabeth , Cannon Matthew , Beaver Larry , Goettl Virginia M. , Lucas David M. , Woyach Jennifer A. , Sampath Deepa , Lehman Amy M. , Yu Lianbo , Zhang Jiazhong , Ma Yan , Zhang Ying , Spevak Wayne , Shi Songyuan , Severson Paul , Shellooe Rafe , Carias Heidi , Tsang Garson , Dong Ken , Ewing Todd , Marimuthu Adhirai , Tantoy Christina , Walters Jason , Sanftner Laura , Rezaei Hamid , Nespi Marika , Matusow Bernice , Habets Gaston , Ibrahim Prabha , Zhang Chao , Mathé Ewy A. , Bollag Gideon , Byrd John C. , Lapalombella Rosa
Published: April 2023

Supplementary Methods
Table S3 from Aurora A Kinase Inhibition Is Synthetic Lethal with Loss of the RB1 Tumor Suppressor Gene
Authors: Gong Xueqian , Du Jian , Parsons Stephen H. , Merzoug Farhana F. , Webster Yue , Iversen Philip W. , Chio Li-Chun , Van Horn Robert D. , Lin Xi , Blosser Wayne , Han Bomie , Jin Shaoling , Yao Sufang , Bian Huimin , Ficklin Chris , Fan Li , Kapoor Avnish , Antonysamy Stephen , Mc Nulty Ann M. , Froning Karen , Manglicmot Danalyn , Pustilnik Anna , Weichert Kenneth , Wasserman Stephen R. , Dowless Michele , Marugán Carlos , Baquero Carmen , Lallena María José , Eastman Scott W. , Hui Yu-Hua , Dieter Matthew Z. , Doman Thompson , Chu Shaoyou , Qian Hui-Rong , Ye Xiang S. , Barda David A. , Plowman Gregory D. , Reinhard Christoph , Campbell Robert M. , Henry James R. , Buchanan Sean G.
Published: April 2023

shRNA suppressor screening data for H446 and MDA-MB-468 cells (tabs 1, 2) and RNA expression level associations with LY3295668 Abs IC50 values from 493 cancer cell lines (tab 3).
Table S2 from Aurora A Kinase Inhibition Is Synthetic Lethal with Loss of the RB1 Tumor Suppressor Gene
Authors: Gong Xueqian , Du Jian , Parsons Stephen H. , Merzoug Farhana F. , Webster Yue , Iversen Philip W. , Chio Li-Chun , Van Horn Robert D. , Lin Xi , Blosser Wayne , Han Bomie , Jin Shaoling , Yao Sufang , Bian Huimin , Ficklin Chris , Fan Li , Kapoor Avnish , Antonysamy Stephen , Mc Nulty Ann M. , Froning Karen , Manglicmot Danalyn , Pustilnik Anna , Weichert Kenneth , Wasserman Stephen R. , Dowless Michele , Marugán Carlos , Baquero Carmen , Lallena María José , Eastman Scott W. , Hui Yu-Hua , Dieter Matthew Z. , Doman Thompson , Chu Shaoyou , Qian Hui-Rong , Ye Xiang S. , Barda David A. , Plowman Gregory D. , Reinhard Christoph , Campbell Robert M. , Henry James R. , Buchanan Sean G.
Published: April 2023

Abs IC50 values (µM) for LY3295668 across a panel of 580 cell lines.
Table S1 from Aurora A Kinase Inhibition Is Synthetic Lethal with Loss of the RB1 Tumor Suppressor Gene
Authors: Gong Xueqian , Du Jian , Parsons Stephen H. , Merzoug Farhana F. , Webster Yue , Iversen Philip W. , Chio Li-Chun , Van Horn Robert D. , Lin Xi , Blosser Wayne , Han Bomie , Jin Shaoling , Yao Sufang , Bian Huimin , Ficklin Chris , Fan Li , Kapoor Avnish , Antonysamy Stephen , Mc Nulty Ann M. , Froning Karen , Manglicmot Danalyn , Pustilnik Anna , Weichert Kenneth , Wasserman Stephen R. , Dowless Michele , Marugán Carlos , Baquero Carmen , Lallena María José , Eastman Scott W. , Hui Yu-Hua , Dieter Matthew Z. , Doman Thompson , Chu Shaoyou , Qian Hui-Rong , Ye Xiang S. , Barda David A. , Plowman Gregory D. , Reinhard Christoph , Campbell Robert M. , Henry James R. , Buchanan Sean G.
Published: April 2023

Abs IC50 values (µM) for 36 small molecule inhibitors across a panel of cancer cell lines.
Supplementary Information from Aurora A Kinase Inhibition Is Synthetic Lethal with Loss of the RB1 Tumor Suppressor Gene
Authors: Gong Xueqian , Du Jian , Parsons Stephen H. , Merzoug Farhana F. , Webster Yue , Iversen Philip W. , Chio Li-Chun , Van Horn Robert D. , Lin Xi , Blosser Wayne , Han Bomie , Jin Shaoling , Yao Sufang , Bian Huimin , Ficklin Chris , Fan Li , Kapoor Avnish , Antonysamy Stephen , Mc Nulty Ann M. , Froning Karen , Manglicmot Danalyn , Pustilnik Anna , Weichert Kenneth , Wasserman Stephen R. , Dowless Michele , Marugán Carlos , Baquero Carmen , Lallena María José , Eastman Scott W. , Hui Yu-Hua , Dieter Matthew Z. , Doman Thompson , Chu Shaoyou , Qian Hui-Rong , Ye Xiang S. , Barda David A. , Plowman Gregory D. , Reinhard Christoph , Campbell Robert M. , Henry James R. , Buchanan Sean G.
Published: April 2023

LY3295668 chemical characterization
Supplementary Figures S1-S15 from Aurora A Kinase Inhibition Is Synthetic Lethal with Loss of the RB1 Tumor Suppressor Gene
Authors: Gong Xueqian , Du Jian , Parsons Stephen H. , Merzoug Farhana F. , Webster Yue , Iversen Philip W. , Chio Li-Chun , Van Horn Robert D. , Lin Xi , Blosser Wayne , Han Bomie , Jin Shaoling , Yao Sufang , Bian Huimin , Ficklin Chris , Fan Li , Kapoor Avnish , Antonysamy Stephen , Mc Nulty Ann M. , Froning Karen , Manglicmot Danalyn , Pustilnik Anna , Weichert Kenneth , Wasserman Stephen R. , Dowless Michele , Marugán Carlos , Baquero Carmen , Lallena María José , Eastman Scott W. , Hui Yu-Hua , Dieter Matthew Z. , Doman Thompson , Chu Shaoyou , Qian Hui-Rong , Ye Xiang S. , Barda David A. , Plowman Gregory D. , Reinhard Christoph , Campbell Robert M. , Henry James R. , Buchanan Sean G.
Published: April 2023

Supplementary figures
Table S5 from Organoid Profiling Identifies Common Responders to Chemotherapy in Pancreatic Cancer
Authors: Tiriac Hervé , Belleau Pascal , Engle Dannielle D. , Plenker Dennis , Deschênes Astrid , Somerville Tim D. D. , Froeling Fieke E. M. , Burkhart Richard A. , Denroche Robert E. , Jang Gun-Ho , Miyabayashi Koji , Young C. Megan , Patel Hardik , Ma Michelle , LaComb Joseph F. , Palmaira Randze Lerie D. , Javed Ammar A. , Huynh Jasmine C. , Johnson Molly , Arora Kanika , Robine Nicolas , Shah Minita , Sanghvi Rashesh , Goetz Austin B. , Lowder Cinthya Y. , Martello Laura , Driehuis Else , LeComte Nicolas , Askan Gokce , Iacobuzio-Donahue Christine A. , Clevers Hans , Wood Laura D. , Hruban Ralph H. , Thompson Elizabeth , Aguirre Andrew J. , Wolpin Brian M. , Sasson Aaron , Kim Joseph , Wu Maoxin , Bucobo Juan Carlos , Allen Peter , Sejpal Divyesh V. , Nealon William , Sullivan James D. , Winter Jordan M. , Gimotty Phyllis A. , Grem Jean L. , DiMaio Dominick J. , Buscaglia Jonathan M. , Grandgenett Paul M. , Brody Jonathan R. , Hollingsworth Michael A. , O'Kane Grainne M. , Notta Faiyaz , Kim Edward , Crawford James M. , Devoe Craig , Ocean Allyson , Wolfgang Christopher L. , Yu Kenneth H. , Li Ellen , Vakoc Christopher R. , Hubert Benjamin , Fischer Sandra E. , Wilson Julie M. , Moffitt Richard , Knox Jennifer , Krasnitz Alexander , Gallinger Steven , Tuveson David A.
Published: April 2023

Table S5
Table S3 from Organoid Profiling Identifies Common Responders to Chemotherapy in Pancreatic Cancer
Authors: Tiriac Hervé , Belleau Pascal , Engle Dannielle D. , Plenker Dennis , Deschênes Astrid , Somerville Tim D. D. , Froeling Fieke E. M. , Burkhart Richard A. , Denroche Robert E. , Jang Gun-Ho , Miyabayashi Koji , Young C. Megan , Patel Hardik , Ma Michelle , LaComb Joseph F. , Palmaira Randze Lerie D. , Javed Ammar A. , Huynh Jasmine C. , Johnson Molly , Arora Kanika , Robine Nicolas , Shah Minita , Sanghvi Rashesh , Goetz Austin B. , Lowder Cinthya Y. , Martello Laura , Driehuis Else , LeComte Nicolas , Askan Gokce , Iacobuzio-Donahue Christine A. , Clevers Hans , Wood Laura D. , Hruban Ralph H. , Thompson Elizabeth , Aguirre Andrew J. , Wolpin Brian M. , Sasson Aaron , Kim Joseph , Wu Maoxin , Bucobo Juan Carlos , Allen Peter , Sejpal Divyesh V. , Nealon William , Sullivan James D. , Winter Jordan M. , Gimotty Phyllis A. , Grem Jean L. , DiMaio Dominick J. , Buscaglia Jonathan M. , Grandgenett Paul M. , Brody Jonathan R. , Hollingsworth Michael A. , O'Kane Grainne M. , Notta Faiyaz , Kim Edward , Crawford James M. , Devoe Craig , Ocean Allyson , Wolfgang Christopher L. , Yu Kenneth H. , Li Ellen , Vakoc Christopher R. , Hubert Benjamin , Fischer Sandra E. , Wilson Julie M. , Moffitt Richard , Knox Jennifer , Krasnitz Alexander , Gallinger Steven , Tuveson David A.
Published: April 2023

Table S3
Table S1 from Organoid Profiling Identifies Common Responders to Chemotherapy in Pancreatic Cancer
Authors: Tiriac Hervé , Belleau Pascal , Engle Dannielle D. , Plenker Dennis , Deschênes Astrid , Somerville Tim D. D. , Froeling Fieke E. M. , Burkhart Richard A. , Denroche Robert E. , Jang Gun-Ho , Miyabayashi Koji , Young C. Megan , Patel Hardik , Ma Michelle , LaComb Joseph F. , Palmaira Randze Lerie D. , Javed Ammar A. , Huynh Jasmine C. , Johnson Molly , Arora Kanika , Robine Nicolas , Shah Minita , Sanghvi Rashesh , Goetz Austin B. , Lowder Cinthya Y. , Martello Laura , Driehuis Else , LeComte Nicolas , Askan Gokce , Iacobuzio-Donahue Christine A. , Clevers Hans , Wood Laura D. , Hruban Ralph H. , Thompson Elizabeth , Aguirre Andrew J. , Wolpin Brian M. , Sasson Aaron , Kim Joseph , Wu Maoxin , Bucobo Juan Carlos , Allen Peter , Sejpal Divyesh V. , Nealon William , Sullivan James D. , Winter Jordan M. , Gimotty Phyllis A. , Grem Jean L. , DiMaio Dominick J. , Buscaglia Jonathan M. , Grandgenett Paul M. , Brody Jonathan R. , Hollingsworth Michael A. , O'Kane Grainne M. , Notta Faiyaz , Kim Edward , Crawford James M. , Devoe Craig , Ocean Allyson , Wolfgang Christopher L. , Yu Kenneth H. , Li Ellen , Vakoc Christopher R. , Hubert Benjamin , Fischer Sandra E. , Wilson Julie M. , Moffitt Richard , Knox Jennifer , Krasnitz Alexander , Gallinger Steven , Tuveson David A.
Published: April 2023

Table S1
Supplemental Table Legends from Organoid Profiling Identifies Common Responders to Chemotherapy in Pancreatic Cancer
Authors: Tiriac Hervé , Belleau Pascal , Engle Dannielle D. , Plenker Dennis , Deschênes Astrid , Somerville Tim D. D. , Froeling Fieke E. M. , Burkhart Richard A. , Denroche Robert E. , Jang Gun-Ho , Miyabayashi Koji , Young C. Megan , Patel Hardik , Ma Michelle , LaComb Joseph F. , Palmaira Randze Lerie D. , Javed Ammar A. , Huynh Jasmine C. , Johnson Molly , Arora Kanika , Robine Nicolas , Shah Minita , Sanghvi Rashesh , Goetz Austin B. , Lowder Cinthya Y. , Martello Laura , Driehuis Else , LeComte Nicolas , Askan Gokce , Iacobuzio-Donahue Christine A. , Clevers Hans , Wood Laura D. , Hruban Ralph H. , Thompson Elizabeth , Aguirre Andrew J. , Wolpin Brian M. , Sasson Aaron , Kim Joseph , Wu Maoxin , Bucobo Juan Carlos , Allen Peter , Sejpal Divyesh V. , Nealon William , Sullivan James D. , Winter Jordan M. , Gimotty Phyllis A. , Grem Jean L. , DiMaio Dominick J. , Buscaglia Jonathan M. , Grandgenett Paul M. , Brody Jonathan R. , Hollingsworth Michael A. , O'Kane Grainne M. , Notta Faiyaz , Kim Edward , Crawford James M. , Devoe Craig , Ocean Allyson , Wolfgang Christopher L. , Yu Kenneth H. , Li Ellen , Vakoc Christopher R. , Hubert Benjamin , Fischer Sandra E. , Wilson Julie M. , Moffitt Richard , Knox Jennifer , Krasnitz Alexander , Gallinger Steven , Tuveson David A.
Published: April 2023

Supplemental Table Legends
Supplemental Figures from Organoid Profiling Identifies Common Responders to Chemotherapy in Pancreatic Cancer
Authors: Tiriac Hervé , Belleau Pascal , Engle Dannielle D. , Plenker Dennis , Deschênes Astrid , Somerville Tim D. D. , Froeling Fieke E. M. , Burkhart Richard A. , Denroche Robert E. , Jang Gun-Ho , Miyabayashi Koji , Young C. Megan , Patel Hardik , Ma Michelle , LaComb Joseph F. , Palmaira Randze Lerie D. , Javed Ammar A. , Huynh Jasmine C. , Johnson Molly , Arora Kanika , Robine Nicolas , Shah Minita , Sanghvi Rashesh , Goetz Austin B. , Lowder Cinthya Y. , Martello Laura , Driehuis Else , LeComte Nicolas , Askan Gokce , Iacobuzio-Donahue Christine A. , Clevers Hans , Wood Laura D. , Hruban Ralph H. , Thompson Elizabeth , Aguirre Andrew J. , Wolpin Brian M. , Sasson Aaron , Kim Joseph , Wu Maoxin , Bucobo Juan Carlos , Allen Peter , Sejpal Divyesh V. , Nealon William , Sullivan James D. , Winter Jordan M. , Gimotty Phyllis A. , Grem Jean L. , DiMaio Dominick J. , Buscaglia Jonathan M. , Grandgenett Paul M. , Brody Jonathan R. , Hollingsworth Michael A. , O'Kane Grainne M. , Notta Faiyaz , Kim Edward , Crawford James M. , Devoe Craig , Ocean Allyson , Wolfgang Christopher L. , Yu Kenneth H. , Li Ellen , Vakoc Christopher R. , Hubert Benjamin , Fischer Sandra E. , Wilson Julie M. , Moffitt Richard , Knox Jennifer , Krasnitz Alexander , Gallinger Steven , Tuveson David A.
Published: April 2023

Supplemental Figures
Supplementary Movie legends from Remodeling of the Collagen Matrix in Aging Skin Promotes Melanoma Metastasis and Affects Immune Cell Motility
Authors: Kaur Amanpreet , Ecker Brett L. , Douglass Stephen M. , Kugel Curtis H. , Webster Marie R. , Almeida Filipe V. , Somasundaram Rajasekharan , Hayden James , Ban Ehsan , Ahmadzadeh Hossein , Franco-Barraza Janusz , Shah Neelima , Mellis Ian A. , Keeney Frederick , Kossenkov Andrew , Tang Hsin-Yao , Yin Xiangfan , Liu Qin , Xu Xiaowei , Fane Mitchell , Brafford Patricia , Herlyn Meenhard , Speicher David W. , Wargo Jennifer A. , Tetzlaff Michael T. , Haydu Lauren E. , Raj Arjun , Shenoy Vivek , Cukierman Edna , Weeraratna Ashani T.
Published: April 2023

Supplemental Legends for Movies
Supplementary Movie 9 from Remodeling of the Collagen Matrix in Aging Skin Promotes Melanoma Metastasis and Affects Immune Cell Motility
Authors: Kaur Amanpreet , Ecker Brett L. , Douglass Stephen M. , Kugel Curtis H. , Webster Marie R. , Almeida Filipe V. , Somasundaram Rajasekharan , Hayden James , Ban Ehsan , Ahmadzadeh Hossein , Franco-Barraza Janusz , Shah Neelima , Mellis Ian A. , Keeney Frederick , Kossenkov Andrew , Tang Hsin-Yao , Yin Xiangfan , Liu Qin , Xu Xiaowei , Fane Mitchell , Brafford Patricia , Herlyn Meenhard , Speicher David W. , Wargo Jennifer A. , Tetzlaff Michael T. , Haydu Lauren E. , Raj Arjun , Shenoy Vivek , Cukierman Edna , Weeraratna Ashani T.
Published: April 2023

Supplementary Movie 9
Supplementary Movie 8 from Remodeling of the Collagen Matrix in Aging Skin Promotes Melanoma Metastasis and Affects Immune Cell Motility
Authors: Kaur Amanpreet , Ecker Brett L. , Douglass Stephen M. , Kugel Curtis H. , Webster Marie R. , Almeida Filipe V. , Somasundaram Rajasekharan , Hayden James , Ban Ehsan , Ahmadzadeh Hossein , Franco-Barraza Janusz , Shah Neelima , Mellis Ian A. , Keeney Frederick , Kossenkov Andrew , Tang Hsin-Yao , Yin Xiangfan , Liu Qin , Xu Xiaowei , Fane Mitchell , Brafford Patricia , Herlyn Meenhard , Speicher David W. , Wargo Jennifer A. , Tetzlaff Michael T. , Haydu Lauren E. , Raj Arjun , Shenoy Vivek , Cukierman Edna , Weeraratna Ashani T.
Published: April 2023

Supplementary Movie 8
Supplementary Movie 4 from Remodeling of the Collagen Matrix in Aging Skin Promotes Melanoma Metastasis and Affects Immune Cell Motility
Authors: Kaur Amanpreet , Ecker Brett L. , Douglass Stephen M. , Kugel Curtis H. , Webster Marie R. , Almeida Filipe V. , Somasundaram Rajasekharan , Hayden James , Ban Ehsan , Ahmadzadeh Hossein , Franco-Barraza Janusz , Shah Neelima , Mellis Ian A. , Keeney Frederick , Kossenkov Andrew , Tang Hsin-Yao , Yin Xiangfan , Liu Qin , Xu Xiaowei , Fane Mitchell , Brafford Patricia , Herlyn Meenhard , Speicher David W. , Wargo Jennifer A. , Tetzlaff Michael T. , Haydu Lauren E. , Raj Arjun , Shenoy Vivek , Cukierman Edna , Weeraratna Ashani T.
Published: April 2023

Supplementary Movie 4
Supplementary Movie 1 from Remodeling of the Collagen Matrix in Aging Skin Promotes Melanoma Metastasis and Affects Immune Cell Motility
Authors: Kaur Amanpreet , Ecker Brett L. , Douglass Stephen M. , Kugel Curtis H. , Webster Marie R. , Almeida Filipe V. , Somasundaram Rajasekharan , Hayden James , Ban Ehsan , Ahmadzadeh Hossein , Franco-Barraza Janusz , Shah Neelima , Mellis Ian A. , Keeney Frederick , Kossenkov Andrew , Tang Hsin-Yao , Yin Xiangfan , Liu Qin , Xu Xiaowei , Fane Mitchell , Brafford Patricia , Herlyn Meenhard , Speicher David W. , Wargo Jennifer A. , Tetzlaff Michael T. , Haydu Lauren E. , Raj Arjun , Shenoy Vivek , Cukierman Edna , Weeraratna Ashani T.
Published: April 2023

Supplementary Movie 1
Supplementary Figures from Remodeling of the Collagen Matrix in Aging Skin Promotes Melanoma Metastasis and Affects Immune Cell Motility
Authors: Kaur Amanpreet , Ecker Brett L. , Douglass Stephen M. , Kugel Curtis H. , Webster Marie R. , Almeida Filipe V. , Somasundaram Rajasekharan , Hayden James , Ban Ehsan , Ahmadzadeh Hossein , Franco-Barraza Janusz , Shah Neelima , Mellis Ian A. , Keeney Frederick , Kossenkov Andrew , Tang Hsin-Yao , Yin Xiangfan , Liu Qin , Xu Xiaowei , Fane Mitchell , Brafford Patricia , Herlyn Meenhard , Speicher David W. , Wargo Jennifer A. , Tetzlaff Michael T. , Haydu Lauren E. , Raj Arjun , Shenoy Vivek , Cukierman Edna , Weeraratna Ashani T.
Published: April 2023

Supplementary Figures
Source Code from Remodeling of the Collagen Matrix in Aging Skin Promotes Melanoma Metastasis and Affects Immune Cell Motility
Authors: Kaur Amanpreet , Ecker Brett L. , Douglass Stephen M. , Kugel Curtis H. , Webster Marie R. , Almeida Filipe V. , Somasundaram Rajasekharan , Hayden James , Ban Ehsan , Ahmadzadeh Hossein , Franco-Barraza Janusz , Shah Neelima , Mellis Ian A. , Keeney Frederick , Kossenkov Andrew , Tang Hsin-Yao , Yin Xiangfan , Liu Qin , Xu Xiaowei , Fane Mitchell , Brafford Patricia , Herlyn Meenhard , Speicher David W. , Wargo Jennifer A. , Tetzlaff Michael T. , Haydu Lauren E. , Raj Arjun , Shenoy Vivek , Cukierman Edna , Weeraratna Ashani T.
Published: April 2023

Source Code for analyses
Supplementary Information from Conversion of PRPS Hexamer to Monomer by AMPK-Mediated Phosphorylation Inhibits Nucleotide Synthesis in Response to Energy Stress
Authors: Qian Xu , Li Xinjian , Tan Lin , Lee Jong-Ho , Xia Yan , Cai Qingsong , Zheng Yanhua , Wang Hongxia , Lorenzi Philip L. , Lu Zhimin
Published: April 2023

Supplementary figure legends and Supplementary Table S1.
Figure S5 from Conversion of PRPS Hexamer to Monomer by AMPK-Mediated Phosphorylation Inhibits Nucleotide Synthesis in Response to Energy Stress
Authors: Qian Xu , Li Xinjian , Tan Lin , Lee Jong-Ho , Xia Yan , Cai Qingsong , Zheng Yanhua , Wang Hongxia , Lorenzi Philip L. , Lu Zhimin
Published: April 2023

AMPK-mediated PRPS1/2 phosphorylation copes with energy stress in tumorigenesis.
Figure S4 from Conversion of PRPS Hexamer to Monomer by AMPK-Mediated Phosphorylation Inhibits Nucleotide Synthesis in Response to Energy Stress
Authors: Qian Xu , Li Xinjian , Tan Lin , Lee Jong-Ho , Xia Yan , Cai Qingsong , Zheng Yanhua , Wang Hongxia , Lorenzi Philip L. , Lu Zhimin
Published: April 2023

AMPK-mediated PRPS1/2 phosphorylation inhibits PRPS1/2 activity and nucleotide synthesis.
Figure S3 from Conversion of PRPS Hexamer to Monomer by AMPK-Mediated Phosphorylation Inhibits Nucleotide Synthesis in Response to Energy Stress
Authors: Qian Xu , Li Xinjian , Tan Lin , Lee Jong-Ho , Xia Yan , Cai Qingsong , Zheng Yanhua , Wang Hongxia , Lorenzi Philip L. , Lu Zhimin
Published: April 2023

AMPK-dependent PRPS1/2 phosphorylation converts PRPS1/2 hexamers to monomers.
Figure S2 from Conversion of PRPS Hexamer to Monomer by AMPK-Mediated Phosphorylation Inhibits Nucleotide Synthesis in Response to Energy Stress
Authors: Qian Xu , Li Xinjian , Tan Lin , Lee Jong-Ho , Xia Yan , Cai Qingsong , Zheng Yanhua , Wang Hongxia , Lorenzi Philip L. , Lu Zhimin
Published: April 2023

AMPK phosphorylates PRPS1 S180 and PRPS2 S183 in response to glucose deprivation.
Figure S1 from Conversion of PRPS Hexamer to Monomer by AMPK-Mediated Phosphorylation Inhibits Nucleotide Synthesis in Response to Energy Stress
Authors: Qian Xu , Li Xinjian , Tan Lin , Lee Jong-Ho , Xia Yan , Cai Qingsong , Zheng Yanhua , Wang Hongxia , Lorenzi Philip L. , Lu Zhimin
Published: April 2023

Energy stresses induce rapid inhibition of PRPS1/2 and nucleic acid synthesis.
Supplementary Figure Legends from Exploiting Drug Addiction Mechanisms to Select against MAPKi-Resistant Melanoma
Authors: Hong Aayoung , Moriceau Gatien , Sun Lu , Lomeli Shirley , Piva Marco , Damoiseaux Robert , Holmen Sheri L. , Sharpless Norman E. , Hugo Willy , Lo Roger S.
Published: April 2023

Supplementary Figure Legends
Figure S8 from Exploiting Drug Addiction Mechanisms to Select against MAPKi-Resistant Melanoma
Authors: Hong Aayoung , Moriceau Gatien , Sun Lu , Lomeli Shirley , Piva Marco , Damoiseaux Robert , Holmen Sheri L. , Sharpless Norman E. , Hugo Willy , Lo Roger S.
Published: April 2023

Supplementary Figure S8. BRAFi plus PARPi augment the cell-death predominant MEKi-addiction phenotype of MUTNRAS melanoma
Figure S5 from Exploiting Drug Addiction Mechanisms to Select against MAPKi-Resistant Melanoma
Authors: Hong Aayoung , Moriceau Gatien , Sun Lu , Lomeli Shirley , Piva Marco , Damoiseaux Robert , Holmen Sheri L. , Sharpless Norman E. , Hugo Willy , Lo Roger S.
Published: April 2023

Supplementary Figure S5. Relationship between p-ERK rebound and p-H2AX induction