bluuebunny/crossref_metadata_2025 huggingface dataset:
Human-machine interactions with clinical phrase prediction system, aligning with Zipf’s least effort principle?
Authors: Zaghir Jamil , Bjelogrlic Mina , Goldman Jean-Philippe , Ehrsam Julien , Gaudet-Blavignac Christophe , Lovis Christian
Published: December 2024

The essence of language and its evolutionary determinants have long been research subjects with multifaceted explorations. This work reports on a large-scale observational study focused on the language use of clinicians interacting with a phrase prediction system in a clinical setting. By adopting principles of adaptation to evolutionary selection pressure, we attempt to identify the major determinants of language emergence specific to this context. The observed adaptation of clinicians’ language behaviour with technology have been confronted to properties shaping language use, and more specifically on two driving forces: conciseness and distinctiveness. Our results suggest that users tailor their interactions to meet these specific forces to minimise the effort required to achieve their objective. At the same time, the study shows that the optimisation is mainly driven by the distinctive nature of interactions, favouring communication accuracy over ease. These results, published for the first time on a large-scale observational study to our knowledge, offer novel fundamental qualitative and quantitative insights into the mechanisms underlying linguistic behaviour among clinicians and its potential implications for language adaptation in human-machine interactions.
Identifying the NEAT1/miR-26b-5p/S100A2 axis as a regulator in Parkinson’s disease based on the ferroptosis-related genes
Authors: Li Taole , Guo Jifeng
Published: December 2024

Objectives

Parkinson’s disease (PD) is a complex neurodegenerative disease with unclear pathogenesis. Some recent studies have shown that there is a close relationship between PD and ferroptosis. We aimed to identify the ferroptosis-related genes (FRGs) and construct competing endogenous RNA (ceRNA) networks to further assess the pathogenesis of PD.

Methods

Expression of 97 substantia nigra (SN) samples were obtained and intersected with FRGs. Bioinformatics analysis, including the gene set enrichment analysis (GSEA), consensus cluster analysis, weight gene co-expression network analysis (WGCNA), and machine learning algorithms, were employed to assess the feasible differentially expressed genes (DEGs). Characteristic signature genes were used to create novel diagnostic models and construct competing endogenous RNA (ceRNA) regulatory network for PD, which were further verified by in vitro experiments and single-cell RNA sequencing (scRNA-seq).

Results

A total of 453 DEGs were identified and 11 FRGs were selected. We sorted the entire PD cohort into two subtypes based on the FRGs and obtained 67 hub genes. According to the five machine algorithms, 4 features (S100A2, GNGT1, NEUROD4, FCN2) were screened and used to create a PD diagnostic model. Corresponding miRNAs and lncRNAs were predicted to construct a ceRNA network. The scRNA-seq and experimental results showed that the signature model had a certain diagnostic effect and lncRNA NEAT1 might regulate the progression of ferroptosis in PD via the NEAT1/miR-26b-5p/S100A2 axis.

Conclusion

The diagnostic signatures based on the four FRGs had certain diagnostic and individual effects. NEAT1/miR-26b-5p/S100A2 axis is associated with ferroptosis in the pathogenesis of PD. Our findings provide new solutions for treating PD.
Systemic immune inflammation index as a predictor of disease severity in tetanus patients: A retrospective observational study
Authors: Cheng Dai , Wenying Ding , Jizheng Huang , Wei Sun , Liang Li , Guolei Han , Hao Yang
Published: December 2024

Objective

This study aimed to analyze the predictive value of the systemic immune inflammation index (SII) for the severity of disease in tetanus patients.

Methods

Clinical data of 34 tetanus patients admitted to the Second People’s Hospital of Fuyang from January 1, 2019 to December 31, 2022 were analyzed. Based on whether patients received intensive care unit (ICU) treatment after admission, the patients were divided into ICU and non-ICU groups. The diagnostic value of SII for the severity of tetanus was assessed.

Results

Among the 34 patients, 18 (52.90%) were classified into the ICU group, and 16 (47.10%) into the non-ICU group. There were statistically significant differences in white blood cell count, platelet count, neutrophil count, and SII between the two groups (P<0.05). Logistic regression analysis revealed that SII was a risk factor for tetanus patients requiring ICU treatment. The area under the curve (AUC) for SII predicting ICU treatment in tetanus patients was 0.896 (95% CI 0.790–1.000, P<0.001).

Conclusion

The SII can serve as an objective predictive indicator for tetanus patients requiring ICU treatment.
The influence of UV-visible light, microwave radiation, argon laser, and heating and aging processes on silicone oil utilized as intravitreal implants: Experimental exposure with clinical correlation
Authors: Al-Dwairi Rami , Ahmad Ahmad. A. , Aleshawi Abdelwahab , Al-Bataineh Qais M. , Bani-Salameh Areen , Aljarrah Ihsan A. , Al Beiruti Seren , Alhabachi Abdulrawof
Published: December 2024

Purpose

The emulsification of silicone oil (SO) remains poorly understood. In the present study, we investigated the physical properties of unused pharmaceutical SO samples under various conditions. Moreover, clinical correlations with the patients’ SO samples were assessed.

Methods

Unused pharmaceutical ophthalmic SO samples and four explanted SO samples from previously vitrectomized patients with rhegmatogenous retinal detachment were analyzed. To assess the stability of SO, the samples were exposed to UV light, visible light, a green argon laser, microwave radiation, heat, and were aged. Following exposure, the samples were investigated using Fourier-transform infrared spectroscopy, optical transmittance and absorbance, and micro-viscometry measurements. Two patients underwent argon laser retinopexy while SO tamponaded the vitreous cavity postoperatively.

Results

The physical properties of SO exposed to heat, UV light, microwave radiation, and aging did not change. However, SO irradiated by the green argon laser demonstrated a significant breakdown of atomic bonding and a transmittance loss. These results are consistent with the analyses of SO samples provided by patients. In those who underwent laser retinopexy, the SO exhibited clinical emulsification necessitating earlier removal, which was confirmed by physical tests.

Conclusions

It may be postulated that patients exposed to the argon laser experienced more emulsification than the other two groups, leading to the earlier removal of the SO implants from the eyes. This investigation did not consider the biological effects of inflammatory biomarkers; however, it may provide valuable insights for optimizing the use of SO in ophthalmic surgery and other potential applications.
Reliability and validity of the original and brief German version of the Maternal Antenatal Attachment Scale (MAAS): Longitudinal study findings
Authors: Lehnig Franziska , Linde Katja , Schmidt Viktoria , Nagl Michaela , Martini Julia , Stepan Holger , Kersting Anette
Published: December 2024

Background

Maternal-foetal attachment (MFA) seems essential for adapting to motherhood and the healthy development of the child, with direct implications for clinical practice. It is often assessed using the Maternal Antenatal Attachment Scale (MAAS), which covers two dimensions: quality and intensity of attachment. However, studies including the MAAS presented missing or inadequate psychometric properties. Therefore, the current study aimed to investigate the reliability and validity of both the original and the recently introduced brief German version of the MAAS.

Materials and methods

Data from 184 pregnant women from a longitudinal study were used. Women (≥ 18 years old) were recruited between the 18th and 22nd weeks of gestation while waiting for routine prenatal diagnostic appointments. Participants answered the MAAS, together with other questionnaires measuring maternal mental health, self-esteem, and social support. For both versions of the MAAS (19 items vs. 13 items), item characteristics, confirmatory factor analysis, internal consistency, and test-retest reliability were calculated and compared. Moreover, associations between the brief German MAAS and theoretically related constructs were analysed using correlation coefficients.

Results

In this study, item analyses revealed better psychometric properties for the brief German MAAS than for the original MAAS, with a significant reduction in items with inadequate discriminatory power. The internal consistency (α ≥ .69) and test-retest reliability (ICC ≥ .62) were acceptable to good for both MAAS versions. With regard to structural validity, factor analysis of the German MAAS presented acceptable to good global model fit indices for the model with correlated factors (GFI > .90; RMSEA ≤ .08; SRMR < .10) in the current sample. In contrast, most global model fit indices of the original MAAS were not acceptable. The construct validity of the German MAAS was demonstrated on the basis of small-to-moderate correlations with a variety of constructs (e.g., measures of depression, anxiety, stress).

Conclusions

According to the present results, the brief German version of the MAAS represents a reliable and valid measurement instrument of MFA for use in clinical practice. Further studies examining possible cut-off values are needed to identify pregnant women with significant attachment difficulties who may benefit from additional support.
Early life stress shifts critical periods and causes precocious visual cortex development
Authors: Poplawski Janet , Montina Tony , Metz Gerlinde A. S.
Published: December 2024

The developing nervous system displays remarkable plasticity in response to sensory stimulation during critical periods of development. Critical periods may also increase the brain’s vulnerability to adverse experiences. Here we show that early-life stress (ELS) in mice shifts the timing of critical periods in the visual cortex. ELS induced by animal transportation on postnatal day 12 accelerated the opening and closing of the visual cortex critical period along with earlier maturation of visual acuity. Staining of a molecular correlate that marks the end of critical period plasticity revealed premature emergence of inhibitory perineuronal nets (PNNs) following ELS. ELS also drove lasting changes in visual cortex mRNA expression affecting genes linked to psychiatric disease risk, with hemispheric asymmetries favoring the right side. NMR spectroscopy and a metabolomics approach revealed that ELS was accompanied by activated energy metabolism and protein biosynthesis. Thus, ELS may accelerate visual system development, resulting in premature opening and closing of critical period plasticity. Overall, the data suggest that ELS desynchronizes the orchestrated temporal sequence of regional brain development potentially leading to long-term functional deficiencies. These observations provide new insights into a neurodevelopmental expense to adaptative brain plasticity. These findings also suggest that shipment of laboratory animals during vulnerable developmental ages may result in long lasting phenotypes, introducing critical confounds to the experimental design.
Exploring the patient’s recovery journey and information needs following a shoulder fracture: A qualitative interview study
Authors: May Pauline , Davies Firoza , Yeowell Gillian , Littlewood Chris
Published: December 2024

Background

Shoulder fractures (proximal humerus fractures) are common, painful, debilitating injuries. Recovery is a long process often hindered by complications such as mal-union and frozen shoulder. The purpose of this qualitative study was to explore the experiences and information needs of people at different time points after a shoulder fracture and how views on recovery change over time.

Methods

This longitudinal telephone interview study used a semi-structured approach based on a pre-planned interview topic guide. Recruitment was from June to November 2023. Participants were interviewed approximately two months and five to six months after their injury. Interviews were audio-recorded and transcribed verbatim. Data were analysed using thematic analysis.

Results

14 participants were recruited (age range 44–80 years; three male). The themes identified were dependence, vulnerability, information needs, and recovery. Loss of function and identity were associated with dependence. Feelings of vulnerability were present for most participants at six months post-injury. Information needs evolved, with information about the extent of the injury and practical advice needed first, but later participants emphasized the importance of reassurance and expected timelines for recovery. Recovery meant regaining function and independence, and returning to meaningful activities, which was also not fully achieved for most participants by six months.

Conclusions

This study is the first to explore information needs and experiences along the timeline of recovery from a shoulder fracture. What recovery means to individual patients, along with recognition of the extent to which feelings of vulnerability affect recovery are important factors to consider. Clinicians should be aware of the full impact of these injuries to guide patients on their recovery journey, including identifying feelings of vulnerability and regaining their identity. Adopting a person-centred care approach, and considering the changing priorities and information needs of patients throughout their recovery journey may lead to improved patient care.
Effectiveness of physiotherapist-led exercise interventions for burn rehabilitation: A systematic review and meta-analysis
Authors: Abonie Ulric Sena , Ackah Martin , Mudawarima Tapfuma , Rockson Alberta
Published: December 2024

Background

Exercise is utilised by physiotherapists to prevent complications and improve overall function and quality of life post-burn. However, the effect of physiotherapist-led exercise has not been comprehensively reviewed. Consequently, this study aimed to investigate the effectiveness of physiotherapy exercises for persons’ post-burn.

Methods

PubMed, CINAHL, Cochrane Library, and Web of Science were searched from database inception to September 27, 2024, to identify relevant studies. Two independent reviewers screened and selected the articles. Studies were included if they were randomised controlled trials of physiotherapy exercises to improve functional outcomes in persons with post burn injuries. Extracted data included author’s surname and year, country, population type, sample size, age, and total body surface area, mode, frequency and duration of exercise. The quality of the evidence was assessed with the Cochrane risk of bias (RoB 2.0) tool. Narrative synthesis and meta-analysis were conducted to examine exercise effect on physical, physiological and psychological outcomes.

Results

Out of 3610 records screened, eight articles involving 393 participants were deemed eligible for inclusion. Physiotherapy exercises significantly improved lean body mass and pulmonary function but did not improve quality of life. Meta-analysis showed significant effects for aerobic capacity (Hedge’s g = 1.13, 95% confidence interval: 0.44–1.83, p = 0.00) and muscle strength (Hedge’s g = 2.27, 95% confidence interval: 0.42–4.13, p = 0.02).

Conclusion

Physiotherapy exercises have positive impacts on physical, physiological and psychological outcomes particularly aerobic capacity and muscle strength in individuals’ post burns. The heterogeneity in effects for all outcomes highlights the need for further research.
Differential contribution of PBP occupancy and efflux on the effectiveness of β-lactams at their target site in clinical isolates of Neisseria gonorrhoeae
Authors: López-Argüello Silvia , Alcoceba Eva , Ordóñez Paula , Taltavull Biel , Cabot Gabriel , Gomis-Font Maria Antonia , Oliver Antonio , Moya Bartolome
Published: December 2024

Neisseria gonorrhoeae exhibits alarming antibiotic resistance trends and poses a significant challenge in therapeutic management. This study aimed to explore the association of penA alleles with penicillin-binding protein (PBP) occupancy patterns and reduced outer membrane permeability, impacting susceptibility to last-line cephalosporins and potential β-lactam candidates. The whole genome sequence, the MICs and PBP IC50s were determined for 12 β-lactams and β-lactamase inhibitors in 8 clinical isolates with varying β-lactam sensitivity, 2 ATCC, and 3 WHO cephalosporin-resistant reference strains. The genetic analysis identified diverse determinants of β-lactam resistance including penA, ponA, porB, and mtrR alterations. Mosaic penA alleles were confirmed to be key determinants of cephalosporin resistance, with notable impacts on PBP2 IC50 affinities (in the presence of all PBPs). Substitutions in positions V316 and A501 exhibited significant effects on β-lactam PBP2 occupancy and MICs. PBP1 inhibition showed marginal effect on β-lactam sensitivity and PBP3 acted as a sink target. Ertapenem and piperacillin emerged as potential therapies against cephalosporin-resistant N. gonorrhoeae strains, along with combination therapies involving tazobactam and/or efflux inhibitors. The study determined the β-lactam PBP-binding affinities of last-line cephalosporins and alternative β-lactam candidates in strains carrying different penA alleles for the first time. These findings provide insights for developing new antimicrobial agents and enhancers against emerging resistant strains. Further research is warranted to optimize therapeutic interventions for cephalosporin-resistant N. gonorrhoeae infections.
Bibliyoṭeḳn: Yiddish Popular Book Series, 1890–1939
Authors: Cohen Nathan
Published: December 2024

The article provides a general overview of a new phenomenon in the Yiddish book market at the end of the 19th century and developed in various directions until the outbreak of World War II. It was numerous initiatives and motivations to publish popular, yet instructive, Yiddish book series, better known as Bibliotekn (libraries) devoted to belle lettres, sciences, political ideologies, and literature for children. From the geographical point of view the article will concentrate in Eastern Europe (i.e. the Pale of Settlement, Congress Poland and the second Polish Republic). The overview will be mainly thematic with a general chronological order.
Safety, Pharmacokinetics, and Clinical Efficacy of ADS051, a Neutrophil Modulator, in Ulcerative Colitis: Results of a Randomized Phase 1b Trial
Authors: Allegretti Jessica R. , Cheifetz Adam S. , Dulai Parambir S. , Stevens A.C. , Chapas-Reed Jillian , Chesnel Laurent , Dixit Bharat , Farquhar Ronald , Ghahramani Parviz , Miller Benjamin W. , Murphy Christopher K. , Quintas Megan , Tanase Raisa , Telia Tengiz , Woźniak-Stolarska Barbara , Gupta Renu
Published: December 2024

INTRODUCTION:

Ulcerative colitis (UC) is characterized by colonic inflammation, with neutrophils playing a key role in UC activity, prognosis, and response to therapies. Current UC therapeutics can have significant side effects and limited efficacy. ADS051 is a novel, oral, gut-restricted small molecule that modulates neutrophil migration and activation without in vitro suppression of T-cell activation. The primary objective of this Phase 1b multidose trial was to evaluate the safety of ADS051. Secondary objectives were clinical activity and pharmacokinetics assessment.

METHODS:

This trial enrolled 24 patients with moderate-to-severe UC in 3 sequential ascending dose cohorts with 3:1 randomization to ADS051 200 mg, 800 mg, or 3,200 mg, or placebo, administered orally once daily for 28 days. Safety, tolerability, and pharmacokinetics were assessed weekly, with clinical activity end points of clinical remission, endoscopic improvement, and histologic remission evaluated at Day 28.

RESULTS:

ADS051 was well tolerated without severe or serious adverse events. High fecal concentrations were achieved with low systemic exposure, with <1% of the daily dose of ADS051 excreted in urine. On Day 28 of the trial, clinical remission was achieved in 22.2% of the pooled ADS051 group vs 0% of the pooled placebo group. Endoscopic response was achieved in 50.0% of ADS051-dosed vs 16.7% of placebo, and endoscopic improvement was achieved in 33.3% of ADS051-dosed vs 0% of placebo.

DISCUSSION:

Phase 1b data in patients with UC indicate a favorable safety profile for ADS051 with encouraging signals of clinical activity, supporting the advancement to a Phase 2 trial.
Cardiovascular Risk From Metabolic Dysfunction-Associated Steatotic Liver Disease, Cardiometabolic Risk Factor Count, and Their Longitudinal Changes: A Nationwide Cohort Study
Authors: Lee Hyeok-Hee , Lee Han Ah , Kim Eun-Jin , Kim Hwi Young , Kim Hyeon Chang , Ahn Sang Hoon , Lee Hokyou , Kim Seung Up
Published: December 2024

INTRODUCTION:

Metabolic dysfunction-associated steatotic liver disease (MASLD) is associated with incident cardiovascular disease (CVD). However, CVD risk could vary across and within individuals with MASLD. We investigated the cardiovascular implications of MASLD, cardiometabolic risk factor count, and their longitudinal changes.

METHODS:

From nationwide health screening data, we included adults aged 20–79 years without increased/excessive alcohol intake, concomitant liver diseases, and prior CVD at baseline examination in 2009 (N = 7,292,497). Participants were classified according to MASLD status; those with MASLD were further categorized by their count of qualifying cardiometabolic risk factors (1–5). Individuals who underwent follow-up examinations in 2011 (N = 4,198,672) were additionally classified according to their baseline and follow-up MASLD status; those with persistent MASLD were further categorized by combination of baseline and follow-up cardiometabolic risk factor counts. The risk of incident CVD was assessed using multivariable-adjusted Cox model.

RESULTS:

Over a median follow-up of 12.3 years, 220,088 new CVD events occurred. The presence of MASLD was associated with higher incidence of CVD. Among participants with MASLD, the risk of CVD increased gradually with higher cardiometabolic risk factor count (per 1-higher; hazard ratio [HR] 1.18, 95% confidence interval [CI] 1.18–1.19). The development of MASLD during follow-up was associated with higher risk of CVD (HR 1.28, 95% CI 1.25–1.31), whereas the regression of MASLD was associated with lower risk of CVD (HR 0.84, 95% CI 0.82–0.86). Among individuals with persistent MASLD, gaining and losing cardiometabolic risk factor count during follow-up were associated with elevated and reduced risk of CVD, respectively.

DISCUSSION:

MASLD status, cardiometabolic risk factor count, and their longitudinal changes were all associated with the risk of incident CVD. Accurate identification of these markers may facilitate personalized management of MASLD-related CVD risk.
Oral Microbiome Dysbiosis Is Associated With Precancerous Lesions and Disorders of Upper Gastrointestinal Tract: A Population-Based Study
Authors: Sadeghi Fatemeh , Sohrabi Amir , Zagai Ulrika , Andreasson Anna , Vieth Michael , Talley Nicholas J. , Agréus Lars , Ye Weimin
Published: December 2024

INTRODUCTION:

Oral microbiota may contribute to the development of upper gastrointestinal (UGI) disorders. In this study, we evaluated the association between microbiota of saliva, subgingival, and buccal mucosa and UGI disorders, particularly precancerous lesions. We also aimed to identify which oral site have the greatest potential as biomarkers for the development of UGI cancers.

METHODS:

In this population-based study, 388 adults underwent upper endoscopy with biopsies for histopathological analysis. UGI symptoms were assessed using a validated questionnaire, and 16S rRNA gene sequencing characterized the microbiota in 380 saliva, 200 subgingival, and 267 buccal mucosa samples collected during endoscopy.

RESULTS:

Dysbiosis of the salivary microbiota was observed in subjects with gastroesophageal reflux symptoms (GERSs) alone, as well as in those with combined conditions such as GERS and esophagitis, or esophagitis and Barrett's esophagus. Significant microbial alterations were also found in individuals with several stomach disorders including Helicobacter pylori infection, chemical reactive gastritis, atrophic gastritis, and intestinal metaplasia. However, microbiota dissimilarity in subgingival and buccal mucosa samples was primarily associated with Barrett's esophagus or gastric atrophy. Among identified genera in saliva, the association between Prevotella and Fusabacterium and atrophic gastritis and intestinal metaplasia was notable. In subgingival samples, the link of Fretibacterium with Barrett's esophagus and Fusabacterium with gastric atrophy and intestinal metaplasia has also been found to be important.

DISCUSSION:

Dysbiosis of saliva microbiota is linked to a broad spectrum of UGI disorders. However, microbiota dysbiosis in subgingival and buccal mucosa sites is specifically associated with the premalignant conditions such as Barrett's esophagus and gastric atrophy. Among oral sites, the subgingival microbiota shows more potential as a infectious biomarker for UGI cancers.
Health Care Utilization of Children Born to Women With and Without Inflammatory Bowel Disease in the First 5 Years of Life: A Population-Cohort Study
Authors: Tandon Parul , Huang Vivian , Feig Denice S. , Saskin Refik , Maxwell Cynthia , Fell Deshayne B. , Seow Cynthia H. , Snelgrove John W. , Nguyen Geoffrey C.
Published: December 2024

INTRODUCTION:

Children born to women with inflammatory bowel disease (IBD) may have increased health care utilization in early life due to genetic susceptibilities and exposure to inflammation in utero, although this has not been robustly evaluated. We aimed to characterize health care use between these groups.

METHODS:

We accessed province-wide health administrative databases to identify children born to women with and without IBD between 2002 and 2019. Differences in hospitalizations, emergency department visits, ambulatory visits, and endoscopy visits in the first 5 years of life were characterized. We further assessed differences in mental health-related health care utilization between groups. Multivariable negative binomial regression was performed to calculate adjusted incidence rate ratios (IRRs) with 95% confidence intervals (CIs).

RESULTS:

We included 17,447 and 1,832,334 children born to women with and without IBD, respectively. Compared with those born to women without IBD, children born to women with IBD appeared to have an increased rate of all-cause hospitalizations (IRR 1.06, 95% CI 1.03–1.10), all-cause emergency department visits (IRR 1.08, 95% CI 1.05–1.10), ambulatory visits (IRR 1.06, 95% CI 1.05–1.07), and endoscopic visits (IRR 2.14, 95% CI 1.70–2.69). Children born to women with IBD also seemed to have increased mental health-related ambulatory visits (IRR 1.93, 95% CI 1.01–3.76), with the most common reasons coded for these visits being neurodevelopmental/behavioral and developmental delay concerns.

DISCUSSION:

Children born to women with IBD may have increased health care utilization compared with those born to women without IBD.
Las representaciones sociales de francés e inglés del estudiantado universitario
Authors: Mai Agustina , Lódolo María Soledad , Sforza Mónica
Published: December 2024

Este artículo presenta los primeros resultados de una investigación en curso sobre las representaciones sociales del estudiantado de la Facultad de Ciencias de la Educación de la Universidad Nacional de Entre Ríos (UNER) en relación con las lenguas extranjeras (LE), que surge ante la necesidad de indagar en su perfil, sus representaciones sociales y expectativas sobre el aprendizaje de idiomas en el ámbito universitario, frente a los cambios socio–históricos actuales. Los objetivos principales son relevar, analizar y comparar las representaciones sociales y expectativas de estudiantes sobre las LE enseñadas en sus carreras; analizar los programas de cátedra y reconfigurar las propuestas didácticas. Basándonos en una metodología cuali–cuantitativa, utilizamos la técnica de encuesta con preguntas cerradas y abiertas sobre un universo de 120 estudiantes de grado, complementada con un grupo focal y el análisis de los programas de cátedras (2018–2023). Entre los resultados preliminares destacamos: el predominio de una concepción instrumentalista de la LE —escasísima vinculación con la cultura—; una vinculación con aspectos afectivos en el francés y económicos en inglés; la subestimación de lo aprendido en la secundaria; y la fuerte asociación entre saber un idioma y poder hablarlo.
Análisis de fotografías para mirar con nuevas lentes la situación educativa
Authors: Lyons Silvina , Jureit Mariana
Published: December 2024

La observación se destaca como una estrategia clave para la formación docente, permitiendo fomentar una mirada crítica y reflexiva sobre la situación educativa. En este trabajo se describe una propuesta de formación docente implementada en la Facultad de Ciencias Médicas de la Universidad Nacional de La Plata, enfocada en la reflexión sobre la enseñanza universitaria a partir de la observación y análisis de fotografías. El Departamento Pedagógico de dicha Facultad diseñó y llevó a cabo un módulo pedagógico dirigido a ayudantes alumnos de la carrera de Medicina. Este módulo incluyó actividades presenciales y a distancia, donde se analizaron imágenes de situaciones educativas utilizando como referencia algunos conceptos del pedagogo Paulo Freire. La experiencia ofreció una oportunidad para que los ayudantes alumnos vieran con nuevas lentes la escena en la que se despliega la enseñanza, a la luz de aportes de las ciencias de la educación, y comenzaran un proceso de revisión de sus prácticas docentes
Acampes por una justicia ecológica: un lustro de trabajo territorial en cuatro localidades de la Provincia de Santa Fe
Authors: Balaudo Cintia Giuliana , María Valeria Berros
Published: December 2024

Este artículo presenta los resultados de un lustro (2019-2023) de trabajo territorial producto de la articulación entre investigación y extensión universitaria vinculada con el acceso a la justicia en materia ambiental y ecológica en cuatro localidades de dos departamentos – Las Colonias y La Capital - de la provincia de Santa Fe en Argentina. En su primer apartado reconstruye la problemática abordada y la metodología utilizada para hacer dialogar líneas de investigación y extensión universitaria en desarrollo en la Facultad de Ciencias Jurídicas y Sociales de la Universidad Nacional del Litoral. En ese sentido, se establece un entramado entre los proyectos de extensión universitaria Acampe por una justicia ecológica y los proyectos de investigación Meulen. Renovación de aportes jurídicos sobre la cuestión ecológica y Meulen II. Profundización de aportes jurídicos sobre la cuestión ecológica desde una perspectiva latinoamericana que aportan herramientas claves para el abordaje del trabajo territorial. En su segunda parte, presenta los resultados obtenidos sobre la percepción de problemas socioambientales y las condiciones de acceso a la justicia ambiental y ecológica en las localidades de Santo Domingo y Humboldt del Departamento Las Colonias y en Arroyo Leyes y San José del Rincón del Departamento La Capital en la provincia de Santa Fe.
Sostenibilidad económica en la industria cervecera mexicana: paradojas en el acceso y uso del agua
Authors: Martínez Sidón Gilberto , González ávila María Eugenia , Vásquez Galán Belem Ileana , Corrales Corrales Salvador
Published: December 2024

En este trabajo se analizó el uso y la disponibilidad de agua bajo el concepto de sostenibilidad, durante el periodo 2013-2020. Se utilizaron diversas bases de datos para calcular el índice de intensidad en el uso de agua, el índice de desarrollo sostenible y el impacto de los precios en las concesiones para producir cerveza, así como la estimación de un modelo de regresión. La paradoja radica en que las cerveceras producen con ganancias en zonas de escasez hídrica, ya que se evidenció que no operan en un ambiente de desarrollo sostenible con fundamento en tres pilares: el social, ambiental y económico. En el primer pilar, sobre la contribución social por la generación de empleos, no supera el consumo de agua industrial y generación de valor agregado, en el segundo pilar que corresponde al ambiental, se encontró un efecto significativo sobre la producción cervecera, mientras que, en el tercero que fue el económico se evidenció que el precio por metro cúbico de agua impuesto por la autoridad no garantiza el uso sustentable del agua en la industria cervecera.
Evaluasi Keamanan Sistem Informasi Dengan Indeks KAMI Dan COBIT 5 Di Pesantren
Authors: Habibullah Ricky , Nuruzzaman Muhammad Taufiq , Mulyanto Agus
Published: December 2024

Penelitian ini bertujuan untuk mengevaluasi keamanan sistem informasi di pondok pesantren se-Kabupaten Jombang dengan menggunakan Indeks KAMI dan kerangka kerja COBIT 5. Sampel penelitian mencakup 10 pesantren yang dipilih secara purposive sampling, mewakili dari total populasi sebanyak 210 pesantren. Evaluasi dilakukan dengan mengumpulkan data melalui kuesioner yang mengukur tingkat kapabilitas pada enam domain utama COBIT 5, yaitu DSS01 (Mengelola Operasi), DSS02 (Mengelola Permintaan Layanan dan Insiden), DSS03 (Mengelola Masalah), DSS04 (Mengelola Keberlanjutan), DSS05 (Mengelola Layanan Keamanan), dan DSS06 (Mengelola Kontrol Proses Bisnis). Analisis menunjukkan bahwa sebagian besar pesantren berada pada Level 2 kapabilitas, yang mencerminkan implementasi praktik dasar keamanan informasi, namun belum optimal. Analisis Indeks KAMI mengungkapkan bahwa hanya sedikit pesantren yang memenuhi validitas Tingkat III, dengan mayoritas pesantren berada pada Tingkat II, menunjukkan perlunya perbaikan dalam tata kelola keamanan informasi. Temuan penelitian ini menegaskan pentingnya penguatan manajemen keamanan informasi melalui pelatihan, pengembangan kebijakan yang komprehensif, dan penerapan teknologi yang lebih canggih untuk memastikan integritas, kerahasiaan, dan ketersediaan data dalam mendukung operasional pendidikan.
Kata kunci: Keamanan Informasi, Indeks KAMI, COBIT 5, Pondok Pesantren, Evaluasi Sistem.
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Abstract
This study aims to evaluate the information system security in pondok pesantren across Jombang Regency using the KAMI Index and the COBIT 5 framework. The study sample consisted of 10 pesantren selected through purposive sampling, representing 10% of the total population of 210 pesantren. The evaluation was conducted by collecting data through questionnaires that assessed capability levels across six main domains of COBIT 5, namely DSS01 (Manage Operations), DSS02 (Manage Service Requests and Incidents), DSS03 (Manage Problems), DSS04 (Manage Continuity), DSS05 (Manage Security Services), and DSS06 (Manage Business Process Controls). The analysis revealed that most pesantren were at Capability Level 2, indicating the implementation of basic information security practices, though not yet optimal. The KAMI Index analysis showed that only a few pesantren met the validity criteria for Level III, with the majority positioned at Level II, highlighting the need for improvements in information security governance. These findings underscore the importance of strengthening information security management through training, comprehensive policy development, and the adoption of advanced technologies to ensure data integrity, confidentiality, and availability in supporting educational operations.
Keywords: Information Security, KAMI Index, COBIT 5, Pondok Pesantren, System Evaluation
Perancangan Tim Security Operation Center Di Perusahaan Sektor Finansial: Studi Kasus Dan Analisis
Authors: Van tony Farel , Setiadi Yazid
Published: December 2024

Tujuan penelitian ini untuk mengetahui perancangan tim security operation center di perusahaan sektor finansial. Keamanan informasi merupakan aspek penting dalam operasional perusahaan sektor finansial yang menangani data sensitif dan pengelolaan risiko global. Tim Security Operations Center (SOC) memainkan peran kunci dalam mendeteksi, menanggapi, dan mencegah serangan siber yang dapat mengganggu stabilitas keuangan. Penelitian ini mengadopsi pendekatan kualitatif deskriptif Penelitian ini bertujuan untuk mengembangkan model perancangan Tim SOC yang efektif di perusahaan sektor finansial. Studi kasus pada perusahaan XYZ menunjukkan bahwa faktor-faktor seperti pengalaman dan kepemimpinan, komunikasi dan kerja sama, teknologi dan alat kritis, serta dukungan manajemen sangat mempengaruhi kesuksesan operasional SOC. Pengelolaan SOC dalam konteks industri cryptocurrency yang memiliki risiko dan dinamika berbeda dari sektor lainnya.  Hasil penelitian menunjukkan bahwa pemahaman mendalam tentang ancaman spesifik dan adaptasi terhadap regulasi yang ketat diperlukan untuk meningkatkan kinerja SOC. Dengan demikian, penelitian ini memberikan panduan untuk optimalisasi dan peningkatan efektivitas Tim SOC dalam menghadapi tantangan keamanan di lingkungan bisnis finansial.
Kata kunci: keamanan informasi, tim security operation center (SOC), sektor finansial, kinerja operasional, stabilitas keuangan
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Abstract
The purpose of this study was to determine the design of the security operation center team in financial sector companies. Information security is an important aspect of the operations of financial sector companies that handle sensitive data and manage global risks. Security Operations Center (SOC) teams play a key role in detecting, responding to, and preventing cyberattacks that can disrupt financial stability. This research adopts a descriptive qualitative approach This research aims to develop an effective SOC Team design model in financial sector companies. The case study of XYZ company shows that factors such as experience and leadership, communication and cooperation, critical technologies and tools, and management support greatly influence the operational success of the SOC. SOC management in the context of the cryptocurrency industry, which has different risks and dynamics from other sectors.  The results show that an in-depth understanding of specific threats and adaptation to strict regulations are required to improve SOC performance. Thus, this research provides guidance for optimizing and improving the effectiveness of the SOC Team in facing security challenges in the financial business environment.
Keywords: information security, security operations center (SOC) team, financial sector, operational performance, financial stability
The Use of Soft Madurese Language (Engghi-Phunten) on Children's Moral Values Development
Authors: Syafitri Rini , Musayyadah Musayyadah
Published: December 2024

Moral values are a relationship between good and bad values that are carried out to guide children's lives. The importance of moral values in children is really needed when children are in their golden age. The use of the Madurese enggi-bunten language is a strong tool in the need for good values. Ingrained in the child. This research was used to look at the moral development of children aged 5-6 years through the use of the Madurese enggi-bunten language at the Al-Azhar Kowel Pamekasan Kindergarten. By using the habituation learning method using Madurese, the research method used was a descriptive qualitative research method with data collection. used are observation, interviews and documentation. The results show that the use of Madurese enggi-bunten language at Kindergarten-Al Azhar Kowel Pamekasan can increase children's moral values and knowledge of Madurese vocabulary, so that children can distinguish good language use when communicating with people around them, whether when communicating with teachers, friends, or parents are accompanied by good and polite actions.
Project on Strengthening Pancasila Student Profiles: Development of Traditional Early Childhood Game Modules in Kepulauan Riau
Authors: Mukhtar Zulfadhly , Selvi Issaura Dwi , Mukhtar AH Nurkamelia , Tassa Amy
Published: December 2024

This study aims to develop a traditional game module of the Kepulauan Riau as part of a project to strengthen the profile of Pancasila students in early childhood. This study uses the Research and Development (R&D) method with the ADDIE model, which includes the stages of analysis, design, development, implementation, and evaluation. The results of the study indicate that this module is effective in increasing children's interest in traditional games while strengthening characters that are in line with Pancasila values such as mutual cooperation, creativity, and cultural diversity. Validation by experts shows that this module has very good feasibility. The trial was conducted in three PAUD institutions in Tanjungpinang and Bintan, with results showing positive responses from students and teachers. This module helps reduce children's dependence on gadgets and introduces them to local cultural values through games. Thus, this module can be a practical guide for teachers in learning activities to preserve traditional games and shape children's characters under the profile of Pancasila students.
The Role of Elementary School Age in Playing in Early Childhood Social Development
Authors: Hutagalung Ahmad Ichsan Yafi
Published: December 2024

Playing is a fun activity for children. With this activity, of course, it can develop social skills because of the interaction that is established. This study aims to determine and analyze the role of age when playing in the social development of early childhood. This type of research uses a qualitative descriptive method with a case study of RA Al-Qur'an Iqro and SD Muhammadiyah 02 Pematangsiantar. The responses in this study were from all RA and SD children who often play together, teachers, and principals. Data collection techniques were by interview, observation, and documentation. The results of this study indicate that the role of elementary school age can help the social development of early childhood. In addition to being able to socialize with peers, RA children also dare to deal with those older than them. In addition, there are several findings in playing activities such as: 1) elementary school children can listen attentively; 2) use good words; 3) play in turns.
Adaptive Urban Renewal Concept Application at Pasar Lama Tangerang, Banten, Indonesia
Authors: Chandra Jennifer Angelyn , Olivia Deasy , Hardi Rachmat Taufick
Published: December 2024

City will always shift and be dynamic. Pasar Lama of Tangerang is the point-zero of Tangerang development as a city, mainly influenced by the Chinese immigrants that move from China and sail to Tangerang. This made Pasar Lama valuable in terms of cultural richness and economic development. But, in times of modern era, Pasar Lama has shifted. The case of Pasar Lama shows how identity shift of a place could result in development imbalance, even harm the cultural product that has developed for hundreds of years. The disruption is caused by the regulation by government and the tourism activities in Pasar Lama that disregards the importance of cultural heritage. This research aims to see the application of adaptive urban renewal approach for cultural heritage space. This research is based on fragmental approach, with descriptive qualitative and spatial analysis. The result shows that adaptive urban renewal application is done through street space optimization to help support tourism, creating pedestrian-only alley that highlights the cultural heritage buildings, and creating a neutral space to bridge two different big cultures. To summarize, adaptive urban renewal could be implemented in Pasar Lama in terms of creating timeless space, which will encourage cultural activities and awareness; all the while maintaining culinary tourism.
“I Just Came to Hang with You Guys”
Authors: Jones Ryan
Published: December 2024

In April 2016, a then 89-year-old Jimmy Heath (1926–2020) accepted an invitation to headline the 50th annual Eau Claire Jazz Festival in Eau Claire, Wisconsin.  This article captures the essence of Heath’s career-long instructional style and contributions to the festival culture at large by spotlighting his involvement with one in particular.  Framed by the dichotomy of his mentorship onstage and off, it presents a case study of unique engagement with younger players and provides a rare opportunity to pore over and contextualize these interactions across a concentrated two-day period.  Citing his words, this treatment showcases the impact of Heath’s dual approach as a jazz legend directing performance on the one hand contrasted with a more informal function as storyteller behind-the-scenes on the other.  But there proved considerably more at work when Heath told his stories than a simple recounting of history alone.  He was in fact teaching.  Telling these stories served as a bona fide instructional method—a pattern borne out by close scrutiny of Heath’s rhetoric that consciously adapted his recollections for the shifting benefits of his various audiences.  Three basic storytelling modes may be grafted on to the typical jazz festival: stories one shares with a general audience in concert, with specialists in a technical masterclass discussion, and with younger musicians in rehearsal or hanging out.  As a result, Heath developed more than one way of telling a story—occasionally the same story—to realize comparable instructional moments in different situations.  This study makes these comparisons explicit.
Remembering Dan Morgenstern (1929-2024)
Authors: Pelote Vincent
Published: December 2024

The following is an obituary and tribute to the late Dan Morgenstern, former editor of the Journal of Jazz Studies, and former Director of the Institute of Jazz Studies.
Guthrie Ramsey in Conversation with Stefon Harris
Authors: Ramsey Guthrie , Harris Stefon
Published: December 2024

On December 14, 2023, Guthrie Ramsey conducted a master class and spoke with Rutgers-Newark faculty member Stefon Harris as part of Express Newark’s “Blues People” exhibition. Dr. Ramsey opened the afternoon with an excerpt of a film he produced “to tell part of the history of African American music.” For the balance of the lecture, Ramsey explored examples of and pedagogical processes related to a type of “vocalization and musicianship” central to Black musicking in America that “gets passed along through oral and aural culture.” Ramsey and Harris's wide ranging coversation returned to many of these themes while addressing Dr. Ramsey's scholarship--past, present and future.