bluuebunny/crossref_metadata_2025 huggingface dataset:
CENP-C-Mis12 complex establishes a regulatory loop through Aurora B for chromosome segregation
Authors: Kong Weixia , Hara Masatoshi , Tokunaga Yurika , Okumura Kazuhiro , Hirano Yasuhiro , Miao Jiahang , Takenoshita Yusuke , Hashimoto Masakazu , Sasaki Hiroshi , Fujimori Toshihiko , Wakabayashi Yuichi , Fukagawa Tatsuo
Published: October 2024

Establishing the correct kinetochore–microtubule attachment is crucial for faithful chromosome segregation. The kinetochore has various regulatory mechanisms for establishing correct bipolar attachment. However, how the regulations are coupled is not fully understood. Here, we demonstrate a regulatory loop between the kinetochore protein CENP-C and Aurora B kinase, which is critical for the error correction of kinetochore–microtubule attachment. This regulatory loop is mediated through the binding of CENP-C to the outer kinetochore Mis12 complex (Mis12C). Although the Mis12C-binding region of CENP-C is dispensable for mouse development and proliferation in human RPE-1 cells, those cells lacking this region display increased mitotic defects. The CENP-C-Mis12C interaction facilitates the centromeric recruitment of Aurora B and the mitotic error correction in human cells. Given that Aurora B reinforces the CENP-C-Mis12C interaction, our findings reveal a positive regulatory loop between Aurora B recruitment and the CENP-C-Mis12C interaction, which ensures chromosome biorientation for accurate chromosome segregation.
The Gargan-Type Continental Tectonosphere: Pb-isotope Age Estimates for Events of the Early, Middle, and Late Geodynamic Epochs of the Earth in Layers of Outer Shell, Crust-Mantle Transition, and Lithospheric Mantle
Authors:   Institute of the Earth's Crust SB RAS, Rasskazov S.V. ,   Irkutsk State University, Yasnygina T.A. ,   Institute of the Earth's Crust SB RAS, Chuvashova I.S. ,   Institute of the Earth's Crust SB RAS,   Irkutsk State University, Saranina E.V. ,   Institute of the Earth's Crust SB RAS,   Vinogradov Institute of Geochemistry SB RAS, Ilyasova A.M. ,   Institute of the Earth's Crust SB RAS, Skopintsev V.G. ,   Individual entrepreneur
Published: October 2024

From Pb-isotope age estimates of protoliths in sources of Cenozoic volcanic rocks and older dikes and sills, as well as Pb age estimates of galena from ore deposits, we define events of the early, middle, and late geodynamic epochs of the Earth's evolution in the Gargan zone of Eastern Sayans. We connect the tectonosphere development in the early geodynamic epoch with impact events of the Earth in the Hadean and Archean, in the middle one – with the Great Oxidation event in the Early Paleoproterozoic, and in the late one – with tectonic integration of the Gargan zone into the basement of the Tuva-Mongolian microcontinent in the Neoproterozoic and early Paleozoic. The conclusions obtained serve as a basis for identifying the Gargan-type continental tectonosphere.
WPPM Index Reporting – How can the key figure of women's quota be appropriately integrated into a reporting system?
Authors: Binder Bettina
Published: October 2024

While women in particular were employed less or not at all in the companies during the Corona crisis period and were unable to participate in the labour market, the number of women in the 40 DAX companies has currently increased again, so that their participation in management and supervisory boards has also increased. In order to ensure better measurability, relevant key figures must be developed that can better reflect the development of women in companies. After the Corona crisis period, management reporting is being re-established in many companies. Innovative key figures are coming into the focus of management and are additionally reported to the individual management levels in favour of traditional key figures. This means that qualitative indicators such as the gender quota and the Women Process Performance Measurement Index (WPPM Index) can ideally be included in management reporting. The following article shows what such a report could look like.
Financial openness of countries in the context of globalization
Authors: Moshenskyi S. , Hordyskyi M. , Pidhorniy O. , Soloviov B.
Published: October 2024

The article examines the trends and aspects of financial openness in countries amid their integration into the international financial space. The analysis shows that the drive towards global integration leads to an increase in economic ties and the intensification of interactions between states, which in turn positively impacts investment opportunities and business conditions. However, the growth of financial openness is accompanied by heightened risks, such as financial crimes, money laundering, and the influence of external economic factors on national markets. The relationship between financial policy, financial openness, and economic stability is explored, along with the role of regulatory measures in ensuring a balance between open financial markets and the protection of national interests. The study includes an analysis of the Chinn-Ito Financial Openness Index as a tool for assessing the level of financial openness in countries. The results indicate that countries with high values of this index typically exhibit significant financial integration, although economic and political factors can lead to variations in the indicators. The importance of harmonizing national legislation with international standards and adapting financial policy to achieve sustainable economic growth and ensure financial stability is highlighted.
Transformation of international security mechanisms in the context of the russian-ukrainian war
Authors: Buriachenko О.
Published: October 2024

The article provides a comprehensive analysis of the transformations in international security mechanisms in the context of the Russia-Ukraine war, ongoing since 2014, with a particular focus on the activities of NATO and the United Nations. The author aims to examine the crisis in the effectiveness of traditional security structures, assess their ability to adapt to new geopolitical realities, and identify the need for the creation of new forms of international security. The research methodology is based on the analysis and synthesis of scientific sources, including works dedicated to the activities of international security organizations, as well as the application of a systematic approach to evaluate the effectiveness of existing security mechanisms. The article examines NATO and the UN's decision-making mechanisms and responses to the Russia-Ukraine war, analyzing their capacity to adequately address the new challenges arising from the armed conflict. The author employs comparative analysis methods to study the changes in the activities of these organizations and analyzes expert assessments to identify key changes in their operations. The study concludes that the Russia-Ukraine war has acted as a catalyst for changes in international security mechanisms, revealing the weaknesses and shortcomings of traditional approaches to global stability. This underscores the need to revise existing strategies, seek innovative approaches to ensuring international security, and potentially create new organizations or coalitions capable of responding more effectively to similar conflicts in the future. The findings of this research may be useful for policymakers, international security experts, and all those interested in the transformation of the global security system.
Mouse Models of HER2+ Human Breast Cancer: A Literature Review
Authors: Al Shammaa Tima
Published: October 2024

Introduction: HER2+ breast cancer (BC) makes up 15-20% of BC cases, where HER2 overexpression drives BC progression via proliferative signals. Targeted therapies inhibit HER2's activity but face challenges like resistance and metastasis. Thus, HER2+ BC is a developing research area where many preclinical studies are being conducted, and mice are often used due to their genetic and physiological similarities to humans. This study aims to review and compare existing mouse models to determine the best model of HER2+ BC. Methods: A literature search on PubMed in February 2024 using search terms including HER2, neu, neuNT, MMTV, and mammary tumors identified 16 primary research articles that used Neu-overexpressing mice. The papers were categorized under five models: MMTV-Neu, MMTV-NeuNT, FloxNeo-NeuNT, MMTV-NIC, and MMTV-HER2. Results: Among examined studies, Andrechek et al.'s FloxNeo-NeuNT model had the longest average tumor onset at 447 days, while Kuang et al.'s MMTV-NIC had the shortest at 126 days. Ursini-Segal et al.'s MMTV-NIC mice showed 100% mammary tumor incidence. Most models resulted in mammary adenocarcinomas, with lung metastases commonly observed, especially in papers that used MMTV-NIC. Discussion: Human HER2+ BC is commonly adenocarcinoma and often metastasizes to lungs, bones, liver, and brain. The mouse models were also found to be adenocarcinomas, but they primarily showed lung metastasis, possibly due to insufficient tumor detection methods for brain and bone metastasis. Neu copy numbers in Andrechek et al.’s FloxNeo-NeuNT model also align with findings on HER2 copy number amplification in human HER2+ BC. Conclusion: We have found that MMTV-NIC is the optimal mouse model for HER2+ BC research due to its short latency, 100% tumor incidence, and high rate of lung metastasis.
THEMES IN ITALIAN NEOREALIST CINEMA: A STUDY OF THE 1940S AND 50S
Authors: Sharma Manoj
Published: October 2024

The paper talks about various themes explored in Italian neorealist cinema of the 1940s and 1950s. During the 1940s and 1950s, Italian filmmakers responded to the artificiality of pre-World War II and Fascist films with a new movement called neorealism (Italian for "new reality"). The movement aimed to address the pre-war events and the social and economic issues that the war spawned realistically. The presentations of events/situations follow certain patterns like poverty, starvation, suffering and struggle for socio-economic justice. There is a clear-cut and distinct emphasis on characterization and the social milieu from which its thematic concerns grow. It aims to make films less glamorous and more helpful as a means of communication for the greater good. It could be suggested that while interacting with the socio-political realities of that period cinema was influencing and being influenced by it. The objective is to show that films do not just appear in a vacuum but are part and product of a specific political, historical, and cultural milieu. They can’t remain divorced from the socio-cultural and political relations of the period they belong to. The themes of anti-Fascism, problems of have v/s have-nots, unemployment, poverty, inequality, and their moral dimensions have been studied.  The de-dramatization of situations and the deviations in the portrayal, as evident in Miracle in Milan (1953), which has been compared with the magic realism of Gabriel Garcia Marquez, have also been discussed.
REVOLUTIONIZING AND DEMOCRATIZING DIGITAL LEARNING: A CASE STUDY OF THE TRANSFORMATIVE IMPACT OF MASSIVE OPEN ONLINE COURSES IN CREATIVE EDUCATION
Authors: Srinivasan Narendhar , Resmi CP  , Rebera Daisy Roshan , Rajalakshmi A
Published: October 2024

This paper explores the transformative influence of Massive Open Online Courses (MOOCs) on creative education, focusing on the democratization of knowledge and analyzing student engagement in virtual classrooms. The primary objective is to investigate how MOOCs democratize knowledge for creative learners, emphasizing the global accessibility, flexibility, and cost-effectiveness of online courses. In-depth interview with working professionals and online learners constitutes the methodology, allowing participants to share experiences and uncover the emotional and personal aspects of their educational journey.Findings reveal that creative learners prefer MOOCs for their flexibility, allowing learning at one's own pace, replaying specific sections, and accessing diverse courses at a lower cost compared to traditional platforms. The inclusivity of MOOCs enables interdisciplinary learning, expanding domain knowledge and fostering collaboration among learners from various backgrounds. The study underscores the practical benefits of increased job opportunities and diverse skill acquisition.
In conclusion, this research highlights the transformative impact of MOOCs, democratizing education for creative learners and offering a paradigm shift in educational delivery. The findings emphasize the need for transparent course information and recorded solutions to enhance the overall learning experience in the evolving landscape of online education.
A STUDY ON CONTRIBUTION OF PANCHAYATI RAJ INSTITUTIONS TO AGRICULTURAL INFRASTRUCTURE DEVELOPMENT IN HANUMANGARH DISTRICT
Authors: Divya
Published: October 2024

The study focuses on the contribution of Panchayat Raj Institutions (PRIs) to agricultural infrastructure development in Hanumangarh District, Rajasthan, over the period from 2013 to 2023. It highlights the proactive role of PRIs in key infrastructure projects such as irrigation schemes, rural roads, storage improvements, and agricultural extension activities (like fairs), which can boost agricultural productivity while promoting sustainable rural development. Based on secondary data, the research identifies a positive relationship between increased infrastructure projects and agricultural productivity, measured in quintals per hectare. It also examines the challenges PRIs face in implementing these projects and identifies critical success factors. The findings suggest that PRIs are actively working to address rural infrastructure gaps and are driving economic growth in the district's agrarian economy. Policy recommendations are made to further strengthen PRI involvement in agricultural infrastructure development.
A CASE REPORT ON THE EFFECTS OF CYRIAX TECHNIQUE (DEEP FRICTION MASSAGE ) APPROACH TO REDUCE PAIN ON LATERAL EPICONDYLITIS
Authors: Shukla Neha , Awasthi Deepanita , Zaidi Aamena , Chandrasekhar Kumar  , Dixit Anamika
Published: October 2024

Background – tennis elbow (lateral epicondylitis) is one of the most common problems of the arm.[1] It is a work-related or sport-related pain disorder with macroscopic and microscopic tears in the extensor carpi radialis brevis [2]. Deep tendon friction (DTF) is a specific type of connective tissue massage which is applied precisely to the soft tissue structures. Deep tendon friction massage is a combination of Mill’s manipulation and is performed immediately after the DTF.[3] The purpose of this case report is to highlight the implementation of cyriax approach in lateral epicondylitis.Objective – reduction of elbow pain and improves rotational limitations. This helps in enhancing the functional activities.
EXPLORING THE ROLE OF NEUROMARKETING IN CONSUMER DECISION-MAKING
Authors: Dwivedi Archana , Sharma Vaibhav
Published: October 2024

This research delves into the emerging field of neuromarketing, examining its role in understanding consumer decision-making processes. Neuromarketing integrates neuroscience principles with marketing strategies to uncover the subconscious factors that influence consumer behavior. Through techniques such as brain imaging technologies, biometric measurements, and implicit association tests, marketers can gain insights into the emotional and cognitive processes that drive purchasing decisions. This study highlights the significance of emotional engagement, memory recall, and decision fatigue in shaping consumer choices. By exploring how emotional connections enhance brand loyalty and the role of memory in brand preference, the research underscores the importance of crafting effective marketing campaigns that resonate with consumers on a deeper level. The findings address the challenges posed by decision fatigue in today’s complex marketplace, emphasizing the need for simplified choices to facilitate consumer decision-making. This research aims to provide a comprehensive understanding of how neuromarketing can inform marketing strategies, fostering more meaningful connections between brands and consumers while promoting ethical considerations in the application of neuroscience in marketing practices.
THE ROLE OF GUIDANCE AND COUNSELLING IN STRENGTHENING STUDENT DISCIPLINE IN SENIOR HIGH SCHOOLS IN SENE EAST DISTRICT OF GHANA
Authors: Gabriel Amponsah Adu  , Srivastava Sujata
Published: October 2024

The study explores the role of guidance and counselling in bolstering student discipline across the two public senior high schools in Sene East District, Ghana. A total of 2,897 participants, including headmasters, school counsellors, teachers, and students, formed the study population. A sample size of 310 was used, comprising randomly selected students, teachers, headmasters, and school counsellors. This sample size constitutes 10% of the total population. The study employed a questionnaire which experts at the University of Education in Winneba validated. The data were analysed through descriptive statistics. The findings indicated that there is a dynamic teacher-student interaction in schools. However, it highlighted inadequate computer facilities within the guidance and counselling setup. Despite improvements in discipline and academic performance attributed to guidance and counselling, challenges such as a lack of legal framework, shortage of trained teacher counsellors, and excessive workload were evident. The study highlights the importance of fostering dialogue and nurturing strong relationships among students, counsellors, teachers, and administrators to promote effective conflict resolution and enhance overall discipline.
Examination of Projects Produced in the Metaverse as an Opportunity for Architecture
Authors: Taş Asli , Mutlu Avinç Güneş
Published: October 2024

The study questions the role of the metaverse universe in the field of architecture. In this context, the article aims to determine this new field's potential, understand its boundaries and analyse what kind of projects have been produced in the architectural field to date. Descriptive analysis, one of the qualitative research methods, was used in the study, and the analysis data was obtained from Archdaily's database, a popular architectural platform. All of the studies obtained from here are current, and the oldest project dates back to 2020. The evaluation of projects was evaluated according to the criteria of different space types (Hyper Reality, Abstracted Reality, Hybrid Cyberspace, Hyper Virtuality), smart city/building, creative-innovative design, social value creation, interaction-socialization, new spatial experiences, digital art, and cultural value creation. Among the projects analyzed, there are projects developed by architects and designed by video and game developers. As a result, in the metaverse universe, futuristic, free designs are developed, and historical and cultural structures are revitalized and passed on to future generations. Complex 3D visualizations can be easily produced in the metaverse instead of using various software. In the future, the metaverse is expected to radically change and transform the discipline of architecture in education, design, and practice.
Identifying Infill Wall Failures in Kahramanmaraş Earthquakes and Strategies for Performance Improvement
Authors: Özdemir Anıl , Çakmak Coşkun
Published: October 2024

Non-structural walls play a very important role in buildings, as they are used to create partitions and provide aesthetic appeal. However, their failures during earthquakes have been a recurring issue. Damage to the infill walls that occurred due to the Kahramanmaraş earthquake on February 6, 2023, was observed in residential and industrial buildings and especially in transformer structures that provide vital electricity distribution. This article presents the findings of field surveys conducted in Kahramanmaraş after recent earthquakes, focusing on non-structural wall collapses that obstructed mainly residential building entrances-exits and structures of particular importance. Within the scope of this study, deficiencies in the certification process in the field of infill walls were seen as the root of workmanship defects. Recommendations were made for the deficiencies in the certification process and for improving the process for the future. Infill walls shouldn’t exhibit out-of-plane behavior, causing loss of life and property and for escape routes to be blocked due to falling walls. With today's technology and engineering, it is possible to positively improve the energy consumption capacity and out-of-plane behavior of infill walls. In this context, a detailed literature review was conducted, and the different techniques used were explained in the article. In addition, explanations were given regarding the force of regulation in Türkiye. Within the scope of the study, the compatibility of regulations and national qualifications in the direction from the design to the production of infill walls is revealed.
Non-Terrestrial Network Concepts in 5G and Beyond Communication Technologies
Authors: Demircioglu Erdem , Ertok Hasan Hüseyin , Çankaya İlyas , Sözbir Nedim
Published: October 2024

Mobile communication systems used in 5G and beyond will provide high-capacity, reliable and low-latency services within wide coverage areas. Currently, terrestrial networks are widely used, but it is expected that these networks will be replaced by hybrid network solutions where terrestrial and non-terrestrial networks operate together. These hybrid ones can perform cutting-edge complimentary solutions when the traditional networks have weak signal levels and geographical difficulties. The main motivation of this study can be stated as the increasing use of hybrid network structures for the solution of digital divine and access problems. In this study, design optimizations of hybrid wireless networks according to different system architectures and performance analyzes are given and various non-terrestrial network technologies are compared.
Drying of Nettle Using Concentrated Air Collector and Concentrated Photovoltaic Thermal Supported Drying System and Modeling with Machine Learning
Authors: Karaagac Mehmet Onur
Published: October 2024

This study examines the performance of a solar assisted drying system in the nettle drying process. The drying process works by using thermal energy obtained from solar air collectors and PV modules. The experimental were carried out in October 2022, and the room temperature, total efficiency and moisture content parameters were investigated. The data obtained from the drying system were modelled using machine learning algorithms such as artificial neural networks (ANN), support vector machines (SVM), and gradient boosting decision trees (GBDT). The average thermal energy transferred to the drying cabin was calculated as 154 W, with 77% of this energy was obtained from the air collector and the remaining 23% from the PV module. The stinging nettle was dried from an initial moisture content of 11.18 g water/g dry matter to a final moisture content of 1.18 g water/g dry matter. The average total efficiency of the drying system was found to be 16.8%. Additionally, the results show that the SVM algorithm exhibits the best performance in estimating important parameters such as chamber temperature, moisture content, and total efficiency. Especially in total efficiency prediction. The SVM algorithm has a significant advantage over other algorithms. As a result, it was concluded that the SVM algorithm can be used effectively utilized in solar energy-supported drying systems and can be a precious choice for the optimization of the drying process.
Necroinfância:
Authors: Guimarães da Silva Pâmela
Published: October 2024

O objetivo deste texto é discutir algumas estratégias midiáticas que favorecem  política de morte contra as crianças negras. Resgatamos a noção de dispositivos de Foucault e abordamos as mídias como parte dos dispositivos, por seu potencial de interlocução de longo alcance. Mostramos como a sociedade brasileira é engendrada pelo dispositivo de racialidade, o qual produz uma heterogeneidade de práticas racistas que se articulam e se realinham para cumprir o objetivo de eliminar – pela necropolítica e pelo epistemicídio – os sujeitos negros. O texto traz uma análise comparativa das coberturas do Caso Henry e do caso dos Meninos desaparecidos de Belford Roxo, realizadas pelo programa Fantástico, durante um ano. O estudo mostra como a mídia atua em prol do dispositivo de racialidade promovendo comoção em torno do caso que envolve uma criança branca, mas não no caso das crianças negras.
Vício nas telas, tempo de sono e a crise do pensamento simbólico
Authors: Balestrini Junior José Luiz , Vieira Maia Sandra Helena , Contrera Malena
Published: October 2024

No presente artigo refletimos sobre a conexão entre o vício nas telas e a crise do pensamento simbólico. Essa dependência patológica retroalimenta a substituição do tempo de contato com as imagens oníricas, que deveria se dar durante o sono, pelo tempo de utilização da internet. Partindo da revisão bibliográfica interdisciplinar como recurso metodológico, utilizamos dados da comunicação, neurociência, psicologia e sociologia, para aprofundarmos a discussão sobre a importância do sono e do sonho para o processo de desenvolvimento cognitivo e comunicacional, tanto do ponto de vista individual, como do coletivo e discutimos como a utilização ideológica capitalista e predatória do imaginário, através de práticas que visam privar as pessoas, cada vez mais, de suas capacidades simbólicas e reflexivas, afastam o indivíduo do tempo-espaço de um dos últimos redutos da expressão das imagens endógenas: o sonho.
semiótica da ironia nos videogames
Authors: Corbello Natalia , Do Prado Márcio Roberto
Published: October 2024

O presente artigo propõe um modelo analítico a partir do qual a ironia pode ser empregada como ferramenta de análise formal da poética dos videogames. No tocante ao conceito de ironia verbal e/ou visual, recorremos ao aporte teórico proporcionado por Ducrot (1987), Brait (2008) e Scott (2004); e às especificidades composicionais dos jogos, exploramos à teoria sobre procedimentalidade elaborada por Bogost (2007, 2008) para propor uma forma de analisar a ironia nos videogames a partir da articulação entre as três linguagens que julgamos mais significativas para sua composição: a verbal, a (audio)visual e a procedimental. Testamos a proposta aplicando-a à análise da ironia no videogame Orgasm simulator (Molleindustria, 2003). Conclui-se que a ironia é construída e marcada pela combinação de sistemas semióticos variados, e que sua linguagem procedimental é capaz de significar ironicamente.
Instapoesia
Authors: Caldeira Helvio , Guimarães Martins Bruno
Published: October 2024

Partindo do fenômeno chamado de instapoesia, este artigo tem como objetivo comentar as dinâmicas dos usuários que utilizam o Instagram para se lançarem como poetas, com reflexões sobre as maneiras com as quais tais autores escrevem e interagem com os seguidores na mídia social. O percurso é iniciado com discussões sobre a própria definição de instapoesia, bem como a plataforma e suas affordances. Logo em seguida, são apresentados apontamentos a partir do estudo netnográfico (Montardo; Jung Rocha, 2005) do perfil dos artistas Rupi Kaur, Igor Pires, Atticus e Amanda Lovelace, que tiveram todas as suas postagens durante o primeiro trimestre de 2022 analisadas de modo a se observar as especificidades desse fazer instapoético em relação às demais emergências literárias dentro e fora dos artefatos digitais.
Memória, experiência estética e modos de resistência no selo Andarilha Edições
Authors: Lima Gonçalves Amorim da Silva Tais , Abreu Matos Daniela
Published: October 2024

Este artigo analisa as estéticas visuais que compõem o selo editorial da Andarilha Edições e como essas acionam um diálogo entre memória, experiência estética e modos de resistência. Para tanto, propomos uma metodologia experimental de andarilhagem, buscando entender os processos envolvidos na materialização visual das literaturas. Em seguida, evidenciamos a maneira como a editora adota um movimento de andarilhar buscando observar as práticas sociais cotidianas, costurando e bordando esse espaço e dinâmicas em suas literaturas. Por fim, acionamos o termo Bahia-Recôncavo para apresentar o modo como a editora de livros promove uma espécie de dissenso e de partilha do sensível estético-política ao demarcar as características e especificidades culturais ligadas ao território do Recôncavo e a publicação de literaturas de comunidades minoritárias.
Editora Guaíra
Authors: De Fátima Figueiredo Gomes Gilvana
Published: October 2024

Este artigo examina a formação do editor Oscar Joseph de Plácido e Silva e as estratégias de estreia da Editora Guaíra. Fundada em 1939, a empresa superou a falta de tradição editorial do Paraná e alcançou relativo sucesso no mercado nacional ao publicar autores renomados. O estudo destaca a importância da rede de contatos e das coleções editoriais para a inserção no mercado competitivo do final da década de 1930 e anos iniciais da década de 1940. Conclui-se que a trajetória da Guaíra reflete as dinâmicas e desafios do mercado editorial brasileiro do século XX.
Prospects for Reducing Gastrotoxicity of Anti-Inflammatory and Analgesic Therapy While Using Amtolmetin Guacil
Authors:   E.A. Vagner Perm State Medical University, Perm, Russian Federation, Konshina T. M. ,   Perm State Pharmaceutical Academy, Perm, Russian Federation, Goldobina G. V. ,   E.A. Vagner Perm State Medical University, Perm, Russian Federation, Bolotskaya N. V. ,   E.A. Vagner Perm State Medical University, Perm, Russian Federation, Burlutskaya A. A. ,   E.A. Vagner Perm State Medical University, Perm, Russian Federation, Khorinko V. P. ,   E.A. Vagner Perm State Medical University, Perm, Russian Federation, Konshina Y. A. ,   Perm State Pharmaceutical Academy, Perm, Russian Federation
Published: October 2024

The most important problem of non-steroid anti-inflammatory drugs (NSAIDs) is a high risk of ulcerogenicity. It is possible to reduce it by the increase in gastric mucosa concentrations of gastroprotective NO. New NSAIDs Amtolmetin guacil (AMG) was registered in Russia in 2013. It is positioned as an effective medicine with gastroprotective action. AMG stimulates capsaicinoid receptors and accumulates NO in the stomach. However, the data on the effectiveness and safety of AMG are few. During its metabolism highly ulcerogenic Tolmetin is formed. The purpose of our research was to study the anti-inflammatory, analgesic and ulcerogenic effect of AMG after intragastric administration. The research was carried out on white nonlinear mice and rats of both sexes. Our study showed that AMG effectively reduced the severity of carrageenan edema of the rat's paw and reduced the number of acetic cramps in mice. Gastric mucosa of most animals was without pathological changes, single shallow erosions without infiltration were found in 32% of animals after administration during 4 days of AMG to rats at a dose of 200 mg/kg once a day. Diclofenac in the same conditions at a dose of 10 mg/kg caused deep defects in 75% of rats. AMG showed pronounced analgesic and anti-inflammatory effect. Our results also confirmed the advantage of AMG compared to diclofenac in its effect on the gastric mucosa.
Complex Diagnostic Technology for Assessing Blood Supply in the Initial Stages of Choroidal Melanoma
Authors:   S. Fyodorov ", Panova I. E. ,   Eye Microsurgery",   Federal State Institution, St. Petersburg Branch, Saint-Petersburg, Russian Federation, Samkovich E. V.
Published: October 2024

To date, there is no doubt that the study of the features of vascularization of choroidal melanoma using modern methods of instrumental diagnostics is not only of diagnostic value, but also determines the choice of treatment tactics and allows predicting the course of the tumor process. Purpose. To study the diagnostic capabilities of various research methods in visualization of the neovascular network of small and medium-sized choroidal melanoma. Material and methods. 5 patients (45 eyes) with choroidal melanoma (19 men, 26 women), aged 22 to 84 (56.03 ±15.29) years, underwent complex diagnostics using various methods of studying the blood supply to the tumor: ultrasound in the color Doppler mode mapping, indocyanine green angiography and spectral optical coherence tomography-angiography. Results. The different diagnostic significance of instrumental methods for the identification of neovascular vasculature in "small" and "medium" choroidal melanomas was established: indocyanine green angiography – 89%, OCT angiography – 71%, ultrasound – 77%. In case of "small" choroidal melanomas, indocyanine green angiography (83%) and OCT angiography (79%) are highly diagnostic in detecting tumor blood supply, while the first type of angioarchitectonics of the neovascular bed was diagnosed with a significantly higher frequency. In case of "medium" melanoma of the choroid, the informative value of angiography with indocyanine green and ultrasound examination was highly significant and made it possible to diagnose the vascular network in all the cases studied. Choroidal melanomas of these sizes are characterized by the presence of predominantly the second type of angioarchitectonics (81%), in which the hypervascular nature of blood flow was significantly more often determined. Conclusion. The results of this study demonstrate that the use of an integrated diagnostic approach provides a high diagnostic value in the study of blood supply to choroidal melanoma, which determines the prospects for continuing this study with the aim of a detailed study of the angioarchitectonics of choroidal melanoma.
The Influence of Orthokeratological Contact Lenses on the Anatomical and Functional State of the Cornea
Authors:   Kyrgyz State Medical Institute of Retraining and Advanced Training named after. S. B. Daniyarov, Bishkek, Republic of Kyrgyzstan, Absatarova N. A. , Usenko V. A. ,   Kyrgyz State Medical Institute of Retraining and Advanced Training named after. S. B. Daniyarov, Bishkek, Republic of Kyrgyzstan, Yunusov M. A. ,   Medical center «Medcenter KG», Bishkek, Republic of Kyrgyzstan
Published: October 2024

Aim: To analyze the potential impact of orthokeratological lenses when correcting myopia on the anatomical and functional state of the cornea. 160 eyes (80 patients) were examined – 60 eyes (30 patients) with mild myopia, 100 eyes (50 patients) with moderate myopia, average age 12.0 ± 0.38 years. Control group – 40 eyes (20 patients), with emmetropia, average age – 13.0 ± 0.45 years. All patients used reverse geometry orthokeratological lenses «Moonlens» from «Sky Optix» in night mode. Research methods. Special research methods were carried out: keratotopography, OCT of the anterior segment of the eye, autorefractometry, ophthalmometry, biometry, skiascopy against the background of cycloplegia, ultrasound of the eye, biomicroscopy, ophthalmoscopy. Results. After the use of orthokeratological lenses, flattening of the cornea from the center to the periphery was revealed with the formation of a negative value of the asphericity index «Q» – exactly (-) 0.57±0.054 (p <0.01); an increase in refraction in the middle and peripheral zones of the cornea with an increase in the asymmetry index «l-S» is 3.0±0.12D (p <0.01). According to the SimK1 and SimK2 meridians, the degree of weakening of refraction in the center of the cornea was revealed (-) 2.32±0.19D and the degree of enhancement of refraction of the cornea in the middle and peripheral zones – (+) 61±0.53D and (+) 0.97 0, 11D. Conclusion. Thus, the identified changes in the anatomical and functional state of the cornea during the treatment of myopia with orthokeratological lenses in the night mode indicate a transformation of the induced myopic defocus.
Audit Committee’s Roles & Effectiveness: Evidence from Indonesia
Authors: Sudjono Andrew Christian , Setiawan Amelia
Published: October 2024

Financial statement manipulation that still occurring nowadays in Indonesia leads the following issue of how audit committee’s functioning within a corporation. This study questions whether audit committee has certain significant role as stated by OJK or just a formality to obey the regulation set by the government. Therefore, this research analyzes the audit committees’ effectiveness in Indonesia by using POJK No. 55/POJK.04/2015 as the basis of measurement. To examine the audit committee’s effectiveness, this research gathers primary data by distributing a questionnaire to audit committee’s in listed companies in Indonesia and to Ikatan Komite Audit Indonesia (IKAI). Based on the responses, the data is then analyzed by using the SEM-PLS approach. It is found that audit committee diligence in audit and decision-making areas significantly increases the audit committee activity. Moreover, audit committee activity and responsibility in internal audit, regulatory compliance, and risk management significantly influence the audit committee’s effectiveness.
Optimation of Fe3+ Ion Desorption Using Sulfonate Modified Silica Gel-GPTMS
Authors: Elvina Elvina , Oktavia Budhi , Nasra Edi , Zainul Rahadian
Published: October 2024

Silica gel is one of the adsorbents widely used in adsorption, but silica gel has a low ability to absorb metals. Hence, modifications need to be made to improve it. Silica gel modified using sulfonate groups from monosodium salt compound of 4-amino-5-hydroxy-2,7-naphthalene disulfonic acid using GPTMS coupling compound for adsorption and desorption of Fe3+ ions by column method was carried out. The adsorption process of Fe3+ ions using silica gel-GPTMS-sulfonate has been carried out in previous studies and obtained an optimum state at pH 6 and a concentration of 20 ppm. After the adsorption process is carried out, the desorption process is continued with variations in the type of desorption eluent and concentration variations. The types of desorption agents are NaCl, CaCl2, HCl, and HNO3, with the optimum desorption agent being HNO3 with a release of 0.077517 mg of Fe3+ ions from 0.1587403 mg of Fe3+ ions absorbed and a desorption percentage of 48.83%. The concentration variations are 0.5 M, 1 M, 2.5 M, and 5 M, with an optimum concentration of 2.5 M HNO3 with a release of 0.098505 mg Fe3+ ions and a desorption percentage of 64.43%.
Oralidade e ancestralidade na capoeira: princípios de uma ética
Authors: Oliveira Kátia Linhaus de
Published: October 2024

A capoeira é uma prática cultural que agrega luta, jogo, dança, esporte e se vincula à história de um povo que viveu a diáspora negra. No mundo da capoeira, os saberes da oralidade e a valorização da
Identidades roraimenses da tradicional influência nordestina ao atual fenômeno migratório transnacional
Authors: Pantoja Patrícia Lima , Silva Marcélia Nicácio da , Zambrano Cora Elena Gonzalo
Published: October 2024

Questões acerca de identidade têm sido frequentemente discutidas na sociedade, considerando que os elementos identitários de uma nação estão em constante transição. Em Roraima, estado localizado no extremo norte do Brasil, as discussões sobre a identidade e a cultura roraimense ainda possuem lacunas, visto que muitas das pesquisas já realizadas se restringem à influência indígena. Além dessa importante característica da identidade local, Roraima foi e é um centro migratório de sujeitos vindos de outros estados brasileiros e dos países vizinhos. Diante disso, o objetivo deste trabalho é refletir acerca da influência dos fatores migratórios na composição das identidades de Roraima, baseado na concepção do sujeito pós-moderno de Hall (2006). Sob a análise de caráter qualitativo, identificamos que parte dos trabalhos publicados até a presente data aborda a identidade indígena. Concluímos que nas múltiplas identidades roraimenses, além da forte influência indígena, incide o marcante fluxo migratório tanto dos diferentes estados brasileiros, principalmente do Norte e Nordeste, quanto venezuelano.
Mapeamento lexical do português falado no Amapá um estudo sobre o campo semântico "corpo humano"
Authors: Santos Matheus Gomes dos , Sanches Romário Duarte
Published: October 2024

O presente trabalho tem como objetivo mapear e analisar a variação lexical do campo semântico corpo humano, dados que são pertencentes ao Atlas Linguístico do Amapá – ALAP. O estudo está ancorado na Dialetologia, tendo como método a Geolinguística Moderna, encarregada de mapear as variedades linguísticas através de cartas linguísticas (Cardoso, 2010, p.15). A pesquisa contou com dados lexicais que já foram coletados pelo ALAP. Foram selecionados 40 informantes, distribuídos em dez localidades do Amapá, conforme a faixa etária e sexo. Os dados foram analisados, pelos autores desta pesquisa, no software de planilhas Excel e a cartografia linguística feita no software de design gráfico Inkscape. A variação lexical encontrada mostrou que apenas nos itens míope e dente do siso houve predominância lexical diferente, respectivamente denominados de falta de vista e dente do juízo. Já nos itens pálpebras, pomo-de-adão, canhoto, seios, útero, rótula e cócegas, as denominações predominantes foram de variantes padrão.
POLÍTICAS LINGUÍSTICAS NA AMAZÔNIA OCIDENTAL: A PROMOÇÃO E PRESERVAÇÃO DAS LÍNGUAS INDÍGENAS
Authors: Levy Keyse Kerolayne , Lopes Queila Barbosa
Published: October 2024

O presente artigo tem por objetivo fazer uma exposição das políticas linguísticas voltadas para as línguas indígenas existentes nos estados que compõem a Amazônia Ocidental, sendo eles: Acre, Amazonas, Roraima e Rondônia. Para tanto, o artigo expõe o que é a categoria políticas linguísticas por meio do aporte teórico de Calvet (2007), Lagares (2018), Neves (2023), dentre outros. Em seguida propomos a exposição e a discussão das políticas linguísticas existentes em cada estado. A metodologia utilizada foi a qualitativa, por meio de pesquisa documental e bibliográfica, e o corpusanalisado no trabalho está constituído de três leis estaduais, duas leis municipais, três resoluções institucionais e um decreto nacional, resultado de busca virtual realizada no primeiro semestre de 2024. Concluiu-se que, apesar das iniciativas estaduais, municipais e por parte de universidades da esfera pública, seja de forma ampla ou menos abrangente, ainda existe um caminho a ser percorrido no que diz respeito à valorização e à promoção das línguas indígenas nesse território.
Tabu linguístico nas denominações dadas à mulher homossexual pensando papéis sociais dos gêneros na sociedade
Authors: Serra Luís Henrique , Mourão Amanda Gomes
Published: October 2024

Analisam-se as denominações dadas à mulher homossexual no estado do Maranhão, estado localizado na região da Amazônia Legal. A análise busca apresentar aspectos do tabu linguístico relacionado à sexualidade e reunir traços de uma imagem social relacionada à mulher no imaginário social. Dessa forma, problematiza-se a questão da homossexualidade e de que forma ela tem sido compreendida nos tempos atuais. Parte-se do pressuposto de que as denominações dadas a mulher homossexual são formas de cristalização de uma mentalidade de uma sociedade patriarcal em que a mulher deve apresentar comportamentos pré-estabelecidos. O trabalho se insere entre os estudos do léxico e do tabu linguístico. Os dados foram coletados por meio de entrevistas no município Vitorino Freire, na região Central do Maranhão, com 35 participantes com um perfil socioeconômico que abarque uma identidade social que representa uma estratificação social daquele município. As entrevistas foram realizadas de modo espontâneo por meio de pesquisa de campo. Os dados desta pesquisa foram analisados a partir de uma discussão no campo das ciências humanas que tematizam a questão tabu sobre a sexualidade e a mentalidade social que se cristaliza no léxico. Os resultados mostram que as denominações dadas à mulher homossexual apresentam significados relacionados a tabus e que revelam uma consciência conservadora ainda hoje sobre a questão da homossexualidade feminina.
PROJETO GIRASSOL –INCENTIVO E ACOMPANHAMENTO DAS ATIVIDADES NAS SALAS DE LEITURA DA REDE MUNICIPAL DE CAXIAS-MA
Authors: Macêdo Ana Célia Pereira Damasceno de , Ribeiro Francigelda , Oliveira Rauenas Silva
Published: October 2024

O presente artigo tem como objetivo analisar a relevância do Projeto Girassol, dado seu impacto no fomento à leitura, reputando-o como proposta potencializadora no processo de construção da competência leitora dos alunos da rede municipal de Caxias -MA. Ametodologia adotada é de abordagem qualitativa, partindo de pressupostos teóricos de autores como Siciliano (2016), Fernando Báez (2004), Pieruccini (2004) entre outros. Foram coletados dados para a exposição e análise da opinião de professores e alunos de escolas já contempladas com o Projeto Girassol que ganham destaque no processo de impulsionar a leitura, destinando um cuidado especial ao espaço das salas de leitura, com mobiliário ergonômico, pintura temática e acervo amplo.
Palavras-chave: Projeto Girassol; educação; leitura e escrita; salas de leitura.
MARCAS DA RESISTÊNCIA FEMININA EM CONTOS E LENDAS AFRO-BRASILEIROS -A CRIAÇÃO DO MUNDO (2007),DE REGINALDO PRAND
Authors: Oliveira Maria Edna Silva Pereira , Costa Lila Léa Cardoso Chaves
Published: October 2024

Investiga-se a representação da personagem feminina Adetutu em Contos e lendas afro-brasileiros -a criação do mundo (2007), de Reginaldo Prandi, obra pertencente ao acervo literário PNBE 2009, existente nas escolas da rede pública. Será examinada a resistência da personagem em meio a um processo de escravidão, aprisionada em um navio negreiro, acionando memórias como elemento de resistência, preservando sua identidade africana, cultura e crenças diante da violenta separação do convívio familiar. Prandi elabora uma narrativa provocativa que permite refletir sobre as imposições a que a mulher negra, na condição de escrava, se encontra. A pesquisa constata a opressão estabelecida à protagonista, em uma relação de sujeição e resistência. A análise apoia-se em PeterBurke (1992), Achimamanda (2009), Hall (2002), Del Priore (2007),Le Goff (1994) e Bhabha (1998), que direcionam suas proposições para a memória, as relações de poder, gênero e os processos de construção da identidade feminina.
Palavras-chave: memória; identidade; resistência; mulher; dominação.
O PEDAGOGO FRENTE AOS DESAFIOS DA GESTÃO ESCOLAR
Authors: MARTINS ELIZANGELA FERNANDES
Published: October 2024

Este artigo tem por objetivo refletir sobre o processo de formação docente, em especial do pedagogo, tendo em vista o trabalho como gestor escolar. O interesse por esse campo de investigação está relacionado ao desenvolvimento de nossa atividade como gestora escolar formada em pedagogia e os desafios que cotidianamente enfrentamos à frente da gestão escolar. O método escolhido para o desenvolvimento deste trabalho foi a pesquisa bibliográfica desenvolvida por meio do levantamento, da seleção e da análise domaterial publicado a respeito do tema. Assim, nos embasamos em Contreras (2002), Nóvoa (1999), Libâneo (2013) dentre outros. E para direcionar nossa reflexão partimos do questionamento: A formação docente, em especial a do pedagogo, oferece condições parasustentar a atuação no campo da gestão escolar? Dessa forma, tecemos reflexões sobre o processo de formação docente e a necessidade de um professor crítico e reflexivo para, em seguida, refletir sobre a formação do Pedagogo que atua na gestão escolar. Os estudos realizados possibilitaram entender o processo de formação docente como contínua, que não se finda e que deve estar concatenado com as exigências e desenvolvimento da sociedade.
Palavras-chaves: formação docente; desafios; pedagogo; gestão escolar.