bluuebunny/crossref_metadata_2025 huggingface dataset:
Revealing Physiochemical Factors and Zooplankton Influencing Microcystis Bloom Toxicity in a Large-Shallow Lake Using Bayesian Machine Learning
Authors: Wang Xiaoxiao , Wang Lan , Shang Mingsheng , Song Lirong , Shan Kun
Published: August 2022

Toxic cyanobacterial blooms have become a severe global hazard to human and environmental health. Most studies have focused on the relationships between cyanobacterial composition and cyanotoxins production. Yet, little is known about the environmental conditions influencing the hazard of cyanotoxins. Here, we analysed a unique 22 sites dataset comprising monthly observations of water quality, cyanobacterial genera, zooplankton assemblages, and microcystins (MCs) quota and concentrations in a large-shallow lake. Missing values of MCs were imputed using a non-negative latent factor (NLF) analysis, and the results achieved a promising accuracy. Furthermore, we used the Bayesian additive regression tree (BART) to quantify how Microcystis bloom toxicity responds to relevant physicochemical characteristics and zooplankton assemblages. As expected, the BART model achieved better performance in Microcystis biomass and MCs concentration predictions than some comparative models, including random forest and multiple linear regression. The importance analysis via BART illustrated that the shade index was overall the best predictor of MCs concentrations, implying the predominant effects of light limitations on the MCs content of Microcystis. Variables of greatest significance to the toxicity of Microcystis also included pH and dissolved inorganic nitrogen. However, total phosphorus was found to be a strong predictor of the biomass of total Microcystis and toxic M. aeruginosa. Together with the partial dependence plot, results revealed the positive correlations between protozoa and Microcystis biomass. In contrast, copepods biomass may regulate the MC quota and concentrations. Overall, our observations arouse universal demands for machine-learning strategies to represent nonlinear relationships between harmful algal blooms and environmental covariates.
Intraspecific Differences in the Venom of Crotalus durissus cumanensis from Colombia
Authors: Rodríguez-Vargas Ariadna , Vega Nohora , Reyes-Montaño Edgar , Corzo Gerardo , Neri-Castro Edgar , Clement Herlinda , Ruiz-Gómez Francisco
Published: August 2022

Biochemical and biological differences in the venom of Crotalus durissus cumanensis from three ecoregions of Colombia were evaluated. Rattlesnakes were collected from the geographic areas of Magdalena Medio (MM), Caribe (CA) and Orinoquía (OR). All three regionally distributed venoms contain proteases, PLA2s and the basic subunit of crotoxin. However, only crotamine was detected in the CA venom. The highest lethality, coagulant, phospholipase A2 and hyaluronidase activities were found in the MM venom. Also, some differences, observed by western blot and immunoaffinity, were found in all three venoms when using commercial antivenoms. Furthermore, all three eco-regional venoms showed intraspecific variability, considering the differences in the abundance and intensity of their components, in addition to the activity and response to commercial antivenoms.
International Perspectives of Prehospital and Hospital Trauma Services: A Literature Review
Authors: Alharbi Rayan Jafnan , Lewis Virginia , Miller Charne
Published: August 2022

Background: Evidence suggests that reductions in the incidence in trauma observed in some countries are related to interventions including legislation around road and vehicle safety measures, public behaviour change campaigns, and changes in trauma response systems. This study aims to briefly review recent refereed and grey literature about prehospital and hospital trauma care services in different regions around the world and describe similarities and differences in identified systems to demonstrate the diversity of characteristics present. Methods: Articles published between 2000 and 2020 were retrieved from MEDLINE and EMBASE. Since detailed comparable information was lacking in the published literature, prehospital emergency service providers’ annual performance reports from selected example countries or regions were reviewed to obtain additional information about the performance of prehospital care. Results: The review retained 34 studies from refereed literature related to trauma systems in different regions. In the U.S. and Canada, the trauma care facilities consisted of five different levels of trauma centres ranging from Level I to Level IV and Level I to Level V, respectively. Hospital care and organisation in Japan is different from the U.S. model, with no dedicated trauma centres; however, patients with severe injury are transported to university hospitals’ emergency departments. Other similarities and differences in regional examples were observed. Conclusions: The refereed literature was dominated by research from developed countries such as Australia, Canada, and the U.S., which all have organised trauma systems. Many European countries have implemented trauma systems between the 1990s and 2000s; however, some countries, such as France and Greece, are still forming an integrated system. This review aims to encourage countries with immature trauma systems to consider the similarities and differences in approaches of other countries to implementing a trauma system.
Increased Mild Vaccine-Related Side Effects and Higher Specific Antibody Titers in Health Care Workers with Previous SARS-CoV-2 Infection after the mRNA BNT162b2 Vaccine
Authors: Ferrari Ludovica , Compagno Mirko , Campogiani Laura , Teti Elisabetta , Mulas Tiziana , Checchi Davide , Alessio Grazia , Caldara Federica , Coppola Luigi , De Simone Giuseppe , Ceccarelli Laura , Spalliera Ilaria , Vitale Pietro , Grelli Sandro , Andreoni Massimo , Sarmati Loredana , Iannetta Marco
Published: August 2022

Background: to evaluate whether prior SARS-CoV-2 infection affects side effects and specific antibody production after vaccination with BNT162b2. Methods: We included 1106 health care workers vaccinated with BNT162b2. We assessed whether prior SARS-CoV-2 infection affects the number and type of side effects and performed a nested case–control analysis comparing plasma levels of specific IgG titers between SARS-CoV-2-naïve and previously infected subjects after the first and the second vaccine doses. Results: After the first dose, SARS-CoV-2-naïve subjects experienced side effects more often than SARS-CoV-2 naïve subjects. Individuals with prior SARS-CoV-2 infection more often reported pain at the injection site, weakness, and fever than SARS-CoV-2-naïve subjects. After the second dose, the frequency of side effects was similar in the two groups. All subjects with prior SARS-CoV-2 infection developed either a high (>100 AU/mL) or intermediate (10–100 AU/mL) antibody titer. Among SARS-CoV-2-naïve subjects, the majority developed an intermediate titer. After the second dose, a high (>2000 AU/mL) antibody titer was more common among subjects with prior SARS-CoV-2 infection. Conclusions: vaccine-related side effects and a higher anti-SARS-CoV-2-RBD IgG titer were more common in subjects with previous infection than in SARS-CoV-2-naïve after the first, but not after the second dose of the BNT162b2 vaccine.
Immune Response of a Heterologous mRNA-1273 Second-Dose Immunization after a First Dose of ChadOx1 against SARS-CoV-2: A Cross-Sectional Study
Authors: Albanesi Beatrice , Godono Alessandro , Comoretto Rosanna Irene , Casabona Elena , Curoso Giuliano , Leone Massimiliano Victor , Milanesio Nicolò , Mirra Ilenia , Montrucchio Giulia , Pittaluga Fabrizia , Cavallo Rossana , Clari Marco , Ciocan Catalina
Published: August 2022

Heterologous vaccination regimens could contribute to broadening vaccination coverage. To date, there is little evidence on the effectiveness of a combination of adenoviral COVID-19 vaccines with a second dose of mRNA vaccines. This study aims to evaluate the antibody response to the SARS-CoV-2 spike protein 25 weeks after vaccination with mRNA-1273 after a first dose of ChAdOx1. A cross-sectional study was conducted collecting sociodemographic data, clinical characteristics, and serological data from among the general population. Antibody levels were expressed as binding antibody units (BAU) per mL (cutoff = 33.8 BAU/mL). Linear regression models were used to assess the relationship between the subjects’ characteristics and anti-SARS-CoV-2 antibody levels. A total of 229 participants were followed up after a median time of 173 days. The overall anti-SARS-CoV-2 IgG antibody titer was 729.0 BAU/mL. The multivariable analysis showed that the only factor associated with anti-SARS-CoV-2 IgG levels was the BMI (p = 0.007), with decreases within the healthy range weight and increases in under- or overweight people. Our results support the use of heterologous COVID-19 vaccination regimens, as they can guarantee a sustained immune antibody response. More studies are needed to understand the link between BMI and body composition and the immune response to COVID-19 vaccinations.
Immunogenicity and Safety of BNT162b2 Homologous Booster Vaccination in People Living with HIV under Effective cART
Authors: Gianserra Laura , Donà Maria Gabriella , Giuliani Eugenia , Stingone Christof , Pontone Martina , Buonomini Anna Rita , Giuliani Massimo , Pimpinelli Fulvia , Morrone Aldo , Latini Alessandra
Published: August 2022

Data on COVID-19 boosting vaccination in people living with HIV (PLWH) are scant. We investigated the immunogenicity and safety of the BNT162b2 homologous boosting vaccination. Anti-SARS-CoV-2 spike antibodies (LIAISON® SARS-CoV-2 S1/S2 IgG test, DiaSorin®), CD4+, CD8+ and viraemia were monitored at T0 (pre-vaccination), T1 (4 weeks after the second dose), T2 (pre-booster) and T3 (4 weeks after the booster dose). Humoral responses were evaluated according to sex, age, BMI, nadir and baseline CD4+ counts, as well as type of cART regimen. Forty-two subjects were included: the median age was 53 years (IQR: 48–61); the median time since HIV was 12.4 years (IQR: 6.5–18.3); the median nadir and baseline CD4+ counts were 165 (IQR: 104–291) and 687 cells/mm3 (IQR: 488–929), respectively. The booster dose was administered at a median of 5.5 months after the second dose. Median anti-SARS-CoV-2 IgG concentration had significantly decreased at T2 compared to T1 (107 vs. 377, p < 0.0001). Antibody levels elicited by the booster dose (median: 1580 AU/mL) were significantly higher compared with those of all the other time points (p < 0.0001). None of the investigated variables significantly affected antibody response induced by the booster dose. Local and systemic side-effects were referred by 23.8% and 14.3% of the subjects, respectively. One patient developed sensorineural hearing loss (SNHL) 24 h after boosting. He recovered auditory function upon endothympanic administration of corticosteroids. The BNT162b2 boosting vaccination in PLWH is safe and greatly increased the immune response with respect to the primary vaccination.
COVID-19 Vaccine Coverage and Sociodemographic, Behavioural and Housing Factors Associated with Vaccination among People Experiencing Homelessness in Toronto, Canada: A Cross-Sectional Study
Authors: Richard Lucie , Liu Michael , Jenkinson Jesse I. R. , Nisenbaum Rosane , Brown Michael , Pedersen Cheryl , Hwang Stephen W.
Published: August 2022

People experiencing homelessness were prioritized for COVID-19 vaccination in Toronto, Canada, due to the high risk of infection and associated complications relative to the general population. We aimed to ascertain COVID-19 vaccine coverage in this population and explore factors associated with the receipt of at least one dose. We collected survey and blood sample data from individuals ages 16+ recruited by random selection at 62 shelters, hotels and encampment sites between 16 June 2021 and 9 September 2021. We report vaccine coverage by dose number and explored sociodemographic, behavioral, health and housing factors associated with vaccination using multivariable modified Poisson regression. In total, 80.4% (95% CI 77.3–83.1%) received at least one vaccine dose, and 63.6% (CI 60.0–67.0%) received two or more doses. Vaccination was positively associated with age (every 10 years adjusted rate ratio (aRR) 1.05 [95% CI 1.03–1.08]), and receipt of influenza vaccination (aRR 1.19 [95% CI 1.11–1.27]). Factors negatively associated with vaccination included female gender (aRR 0.92 [95% CI 0.85–1.0]), Black racial self-identification (aRR 0.89 [95% CI 0.80–0.99]) and low frequencies of masking in public places (aRR 0.83 [95% CI 0.72–0.95]). COVID-19 vaccine coverage is very high among people experiencing homelessness in Toronto, suggesting advocacy and outreach efforts may have been effective.
Decisions to Choose COVID-19 Vaccination by Health Care Workers in a Southern California Safety Net Medical Center Vary by Sociodemographic Factors
Authors: Garcia Lauren , Firek Anthony , Freund Deborah , Massai Donatella , Khurana Dhruv , Lee Jerusha E. , Zamarripa Susanna , Sasaninia Bijan , Michaels Kelsey , Nightingale Judi , Gatto Nicole M.
Published: August 2022

Background: Limited information exists regarding COVID-19 vaccine hesitancy among healthcare workers (HCWs). Our previous survey analyzed the reasons for HCWs’ decisions to accept vaccination, suggesting that a “one-size fits all” approach may not suffice to increase vaccine uptake. Methods: Based on the vaccination acceptance group (acceptor, hesitant, refuser), we examined differences by sociodemographic factors (race/ethnicity, household income, education) from Likert Scale responses to fourteen influences affecting a decision to be vaccinated using the Kruskal–Wallis test and multinomial logistic regression with mutual adjustment for these sociodemographic factors, age, and sex. Results: Non-Hispanic White vaccine acceptors ranked lower confidence in preventing, withstanding, or treating COVID-19, while Non-Hispanic Blacks more highly regarded the motivation of a religious leader, colleague, or family member. Social media was ranked more influential among Non-Hispanic Asians. Acceptors with lower incomes ranked a job requirement influential; conversely, higher income vaccine hesitant HCWs highly rated this reason. More highly educated acceptors ranked being motivated by colleagues, family, and other HCWs higher. Adjustment weakened some but not all the differences between groups. Conclusions: Sociodemographic factors affect HCWs’ decisions to be vaccinated against COVID-19. Our findings may help develop more focused and tailored strategies to improve vaccination acceptance.
Peptide-Based Vaccines in Clinical Phases and New Potential Therapeutic Targets as a New Approach for Breast Cancer: A Review
Authors: Nicolás-Morales María Lilia , Luisa-Sanjuan Arianna , Gutiérrez-Torres Mayralina , Vences-Velázquez Amalia , Ortuño-Pineda Carlos , Espinoza-Rojo Mónica , Navarro-Tito Napoleón , Cortés-Sarabia Karen
Published: August 2022

Breast cancer is the leading cause of death in women from 20 to 59 years old. The conventional treatment includes surgery, chemotherapy, hormonal therapy, and immunotherapy. This immunotherapy is based on administering monoclonal therapeutic antibodies (passive) or vaccines (active) with therapeutic purposes. Several types of vaccines could be used as potential treatments for cancer, including whole-cell, DNA, RNA, and peptide-based vaccines. Peptides used to develop vaccines are derived from tumor-associated antigens or tumor-specific antigens, such as HER-2, MUC1, ErbB2, CEA, FRα, MAGE A1, A3, and A10, NY-ESO-1, among others. Peptide-based vaccines provide some advantages, such as low cost, purity of the antigen, and the induction of humoral and cellular immune response. In this review, we explore the different types of vaccines against breast cancer with a specific focus on the description of peptide-based vaccines, their composition, immune response induction, and the description of new potential therapeutic targets.
Emergence, Dissemination and Antimicrobial Resistance of the Main Poultry-Associated Salmonella Serovars in Brazil
Authors: Kipper Diéssy , Mascitti Andréa Karoline , De Carli Silvia , Carneiro Andressa Matos , Streck André Felipe , Fonseca André Salvador Kazantzi , Ikuta Nilo , Lunge Vagner Ricardo
Published: August 2022

Salmonella infects poultry, and it is also a human foodborne pathogen. This bacterial genus is classified into several serovars/lineages, some of them showing high antimicrobial resistance (AMR). The ease of Salmonella transmission in farms, slaughterhouses, and eggs industries has made controlling it a real challenge in the poultry-production chains. This review describes the emergence, dissemination, and AMR of the main Salmonella serovars and lineages detected in Brazilian poultry. It is reported that few serovars emerged and have been more widely disseminated in breeders, broilers, and layers in the last 70 years. Salmonella Gallinarum was the first to spread on the farms, remaining as a concerning poultry pathogen. Salmonella Typhimurium and Enteritidis were also largely detected in poultry and foods (eggs, chicken, turkey), being associated with several human foodborne outbreaks. Salmonella Heidelberg and Minnesota have been more widely spread in recent years, resulting in frequent chicken/turkey meat contamination. A few more serovars (Infantis, Newport, Hadar, Senftenberg, Schwarzengrund, and Mbandaka, among others) were also detected, but less frequently and usually in specific poultry-production regions. AMR has been identified in most isolates, highlighting multi-drug resistance in specific poultry lineages from the serovars Typhimurium, Heidelberg, and Minnesota. Epidemiological studies are necessary to trace and control this pathogen in Brazilian commercial poultry production chains.
Elimination of Microplastics at Different Stages in Wastewater Treatment Plants
Authors: Kwon Hyuk Jun , Hidayaturrahman Haerul , Peera Shaik Gouse , Lee Tae Gwan
Published: August 2022

Microplastic pollution has been widely studied as a global issue due to increased plastic usage and its effect on human and aquatic life. Microplastics originate from domestic and industrial activities. Wastewater treatment plants (WWTPs) play an important role in removing a significant amount of microplastics; otherwise, they end up in bioaccumulation. This study provides knowledge about the characteristics of microplastics, removal efficiency, and the correlation between wastewater quality and microplastic concentrations from three different WWTPs that differ in the type of biological and advanced wastewater treatment techniques that are believed to play an important role in microplastic removal. Microplastics of different types, such as fragments, fibers, and beads, are identified by using an optical microscope before and after the treatment process at each stage to assess the effect of different treatment techniques. In the screening unit and primary clarifier unit, WWTP-B shows the highest removal efficiency with 74.76% due to a distribution flow system installed before the primary clarifier to ensure a constant flow of wastewater. WWTP-B uses a bioreactor consisting of a filter plate coated with activated carbon (BSTS II) that can enhance the adaptability and adhesion of microorganisms and showed that 91.04% of the microplastic was removed. Furthermore, only WWTP-A and WWTP-B were applied coagulation, followed by the disc filter; they showed significant results in microplastic removal, compared to WWTP-C, which only used a disc filter. In conclusion, from all WWTP, WWTP-B shows good treatment series for removing microplastic in wastewater; however, WWTP-B showed a high rate of microplastic removal; unfortunately, large amounts of microplastics are still released into rivers.
Simulation of CuE Copper Alloy in a Closed-Die Multi-Axial Forging Tool
Authors: Bíró Tamás , Juhász Zsombor , Renkó József Bálint
Published: August 2022

Two-way multi-axial forging was performed on a newly designed closed-die forging tool. The tool was operated on an MTS 810 material testing system. The connected computer recorded force and crosshead displacement as a function of time during operation. The sample material of the four-step forging experiment was CuE copper alloy. The plastic deformation was 0.8 per step, thus the rate of cumulative equivalent plastic strain was 3.2 by the end of the process. The speed of movement of the active tools during the whole test was 2 mm/min. Finite element simulation was performed with QForm3D software to investigate the force conditions of the process. The necessary flow curve was determined by Watts-Ford test. The force-displacement curves of the physical simulation were compared with the results of the finite element modeling.
Reinforced Matrix Syntactic Foams Filled with Ceramic Hollow Spheres
Authors: Maróti János Endre , Szovák Benedek , Orbulov Imre Norbert
Published: August 2022

Metal matrix syntactic foams are cellular materials in which the matrix is metal and within that matrix are non-metallic cells formed by filler material. These materials have low density, and besides that, they have high compressive strength and energy absorption. The main goal was to improve these properties by reinforcing the matrix with ceramic grains. During the experiment, molten A356 aluminium (7Si-0,3Mg) was infiltrated between the mixture of the filler and the reinforcement material. The specimens were produced with low-pressure infiltration. Different reinforcement materials were used: aluminium-oxide with three different grain sizes and colour designations and one type of silicon carbide. After heat-treatment, standardised compression tests were executed on the specimens. The results were compared to the results of the non-reinforced samples.
Investigation of the Effect of Over-Etching During Color Etching
Authors: Renkó József Bálint , Szabó Péter János
Published: August 2022

During color etching, the examined grain structure undergoes a continuous, cyclic color change. This phenomenon is accompanied by a continuous loss of light intensity reflected from the surface. If the etching process is not stopped in time, the surface will be over etched. As a result, the separability of the individual grains will be greatly damaged, which can lead to a significant loss of information. It was investigated how to determine the moment of over-etching for each grain. During the in-situ observation of the etching, the time at which a particle can be considered over etched was determined by measuring the luminance normalized to the initial state.
Development of a Novel Hybrid Manufacturing Technology For Continuous Fiber-Reinforced Thermo-Plastic Composites
Authors: Tóth Csenge , Kovács Norbert Krisztián
Published: August 2022

In this study, we present a novel approach for the production of continuous fiber-reinforced thermoplastic composites by combining injection molding and additive manufacturing. After exploring the design requirements, we manufactured inserts via continuous fiber-reinforced 3D printing, then we used them as reinforcement for injection-molded samples. Improper fiber placement can cause warpage as the continuous fibers prevent shrinking; however, warpage can be compensated with the insert geometry. The reinforcement resulted in an increase of about 30% in the properties tested.
Analysis of Thermogravimetric and Dynamic Mechanical Properties of PLA/PBS Blends Doped With Zinc Oxide Nanoparticles
Authors: Virág Ábris Dávid , Molnár Kolos
Published: August 2022

In the present work, PLA-PBS blends of 80/20 weight ratio were doped with zinc oxide (2.5; 5; 7.5 and 10 phr) and the flow, thermogravimetric and thermomechanical behaviour of the resulting blends were investigated. Using capillary plasstometry, thermogravimetry (TGA) and dynamic mechanical analysis (DMA), it was found that the increase in zinc oxide content resulted in an increase in the flow indices (MFI, MVR), as well as in the storage and loss modulus values, and a decrease in the thermal stability and glass transition temperature.
The protective effect of caffeic acid phenethyl ester on cadmium-induced liver toxicity: A histopathological and biochemical study
Authors: DEVECİ Haci Ahmet , NUR Gökhan , KÜKÜRT Abdulsamed , KURU Mushap , DEVECİ Ayla
Published: August 2022

In this study, the changes caused by caffeic acid phenethyl ester (CAPE) in the histopathological and biochemical parameters in the oxidant / antioxidant balance in mice with experimental cadmium toxicity were investigated. A total of 40 female Swiss albino mice were used, with 10 mice in each group. The mice were divided into four groups (Group I - Control group, Group II - CAPE group, Group III - Cadmium group, Group IV - Cadmium + CAPE group). Plasma paraoxonase (PON) activity, high-density lipoprotein (HDL), low-density lipoprotein (LDL), total sialic acid (TSA), total antioxidant capacity (TAC), total oxidant capacity (TOC), and oxidative stress index (OSI) were analyzed on mice’s blood samples. The results showed that cadmium intoxication triggered oxidative stress in the mice. It also lowered their PON activity alongside TAC and HDL levels (P<0.001, P<0.01, and P<0.01, respectively) and increased their TSA, LDL, TOC, and OSI levels (P<0.05, P<0.01, P<0.01, and P<0.01, respectively). The histopathological examination of the liver tissues revealed focal apoptotic regions, sinusoidal occlusion, and irregularity in the cadmium group and no significant change in the other groups. These results indicated that CAPE can significantly prevent biochemical and histopathological changes due to cadmium damage.
Presentación
Authors: Goldman Noemí
Published: August 2022

Presentación a cargo de Noemí Goldman.
Jorge Gelman y los espacios de construcción del saber histórico
Authors: Míguez Eduardo
Published: August 2022

Se presentan algunas formas de construcción de saber histórico elaboradas por Jorge Gelman en el campo de la disciplina.
Los mecanismos y sus funcionamientos: notas sobre la vocación antisustancialista
Authors: Barriera Darío G.
Published: August 2022

Reflexiones sobre el trabajo de Zacarías Moutoukias acerca de las investigaciones de Jorge Gelman en torno al comercio colonial.
Historia agraria en el Uruguay: la cuestión agraria y después
Authors: Moraes María Inés
Published: August 2022

Este trabajo analiza la historiografía uruguaya sobre temas agrarios y rurales desde la mitad del siglo XX hasta el presente. Propone una clave de lectura de la historiografía rural uruguaya de los últimos 60 años, al colocarla en el contexto intelectual del ascenso y crisis de lo que aquí se denomina, siguiendo al filósofo de la ciencia Imre Lakatos, el programa de investigación de la cuestión agraria.
Association of Ozoniotherapy to Endodontics, aiming at the tissue repair of periapical lesions - a literature review / Associação da Ozonioterapia à Endodontia, visando o reparo tecidual de lesões periapicais – uma revisão de literatura
Authors: Silva Elane Lima da , Morais Beatriz Silveira de , Vivacqua Flavia Darius
Published: August 2022

Introduction: The success of endodontic treatment is related to the cleaning and elimination of microorganisms and their by-products present in root canals for periapical tissue repair. Objective: To verify the efficacy of ozone (O3) as an adjunct in the therapeutic protocol of Endodontics, aiming to assist in tissue repair of periapic lesions. Methods: This is a literature review, in which scientific articles were researched, from the last 10 years, using the databases of pubmed, scielo, vhl and EBSCOhost platforms, and applying the keywords: "Ozone", "Dentistry", "Endodontics" and "Complementary therapy". Results and Discussion: The applicability of O3 is directly dependent on the performance of the well-executed endodontic treatment, to determine the best way of presenting it, increasing its effectiveness. However, during the preparation of the conduits, ozone can be used in the form of gas, being used within them, with antimicrobial purpose, highlighting the oxidative property that allows better distribution of blood flow to the tissues involved, allowing the acceleration of healing in periapic and periodontal tissues in order to stimulate tissue repair. Ozonized water can be used within the root canal, assisting in disinfection of the conduits; and ozonized oil as an intracanal dressing, both of which can be used alone or together. Conclusion: Ozone therapy is an aggregator in endodontic therapy, since it has three forms of use and several important properties to be added to the treatment, highlighting its gaseous form for assisting in the acceleration of the healing of tissue and bone repair of periapic lesions.
Business consultancy and strategic planning for micro and small companies
Authors: Policário Schirley Maria , De Azevedo Adriano Freitas , Chaves Daniel Caetano do Nascimento , Deorce Raquel Berger , Moreira Nathalia Carvalho
Published: August 2022

In Brazil, micro and small companies play an important role in the economy, however, many of these establishments face difficulties in their trajectory, affecting their longevity. In this way, business consulting can act as an important support tool, helping to improve performance. In this context, the objective of this work is to demonstrate the importance of business consulting for micro and small companies, through a theoretical and bibliographic review, focused on business consulting through its tools and techniques applied to micro and small companies, as well as their respective analyses, conclusions and suggestions, demonstrating the impact and importance that such a service can bring to these companies. The results showed that business consulting focused on MSCs contributes significantly to the improvement of MSCs. On the other hand, there are still barriers to its use, such as the great resistance on the part of entrepreneurs, either for fear of losing control of the company or exposing their data, or even for the cost of hiring.
Miomatose uterina gigante na gestação: um relato de caso
Authors: Arana Alejandra Danae Moura , Torres Bruna Soares , Daou Camila Sampaio , Kabuki Patrícia Burgos Monteiro , Brito Patrícia Leite
Published: August 2022

Introdução: O mioma ou fibroma uterino é o tumor pélvico benigno mais frequente em mulheres na idade reprodutiva. Objetivo: Relatar o caso de uma paciente diagnosticada com leiomioma uterino de grande volume concomitante à gestação. Método: As informações contidas neste trabalho foram obtidas por meio de revisão do prontuário, registro fotográfico dos métodos diagnósticos aos quais a paciente foi submetida, acompanhamento da mesma e revisão da literatura. Considerações finais: O relato de caso  sobre o diagnóstico de leiomioma uterino gigante na gestação possibilitou discussão sobre a necessidade de existir um acompanhamento pré- natal adequado e cuidadoso, especialmente acerca da abordagem que será dada ao leiomioma quando do desfecho da gestação, uma vez que o mesmo provocava prejuízos à saúde da paciente.
Uso e conhecimento de anticoncepcionais hormonais orais de mulheres em graduação / Usage and knowledge of birth control pills in undergraduate women
Authors: Sirqueira Sarah Valões Tenorio , Oliveira Gisele Vasconcelos Calheiros de , Costa Alessa Moísa Barros , Borges Isabela Caracas Machado , Fachin Laércio Pol , Garbini Lavici dos Anjos de Melo Costa
Published: August 2022

Introdução: Os contraceptivos hormonais orais (CHOs) representam até hoje uma das opções contraceptivas reversíveis mais eficazes e um dos métodos de planejamento familiar mais utilizado em todo o mundo. A escolha do método contraceptivo deve visar atender as necessidades e objetivos de cada mulher de forma personalizada. Os CHOs são compostos por hormônios sintéticos de estrógeno e/ou progesterona, dessa forma, inibem a ovulação. Interação medicamentosa é o acontecimento clínico em que os efeitos de um fármaco são alterados quando associado a outro fármaco, alimento, bebida ou algum agente químico ambiental. Tal fenômeno pode ser tanto potencializador (sinergismo) quanto inibitório (antagonismo), assim, existe uma grande quantidade de fármacos capazes de provocar a diminuição da eficácia contraceptiva, popularmente conhecida como “corte do efeito”. Objetivo: Identificar o conhecimento de mulheres sobre o uso de pílula anticoncepcional, seus efeitos e interações medicamentosas. Metodologia: Foi realizada uma pesquisa exploratória, transversal e quantitativa com 48 alunas do curso de graduação em medicina, por meio de um questionário semiestruturado no período de outubro de 2020 a fevereiro de 2021. Resultados: Observou-se que o perfil predominante da amostra da pesquisa é de mulheres jovens, entre 18 e 27 anos, solteiras e sem filhos. A maioria das mulheres alegaram uma renda de mais de 12 e de 3 a 6 salários mínimos. Nenhuma das participantes alegou fazer uso de tabaco, sendo a maioria apenas etilista. A maior parte das mulheres disseram fazer uso dos CHOs sob orientação médica, mas um número relevante não realizou exames antes da prescrição, e, ainda, quase 3/4 delas afirmaram já ter esquecido de tomar o anticoncepcional pelo menos 1 vez. 30 das 48 mulheres tinham conhecimento acerca da possibilidade de interações medicamentosas entre anticoncepcionais hormonais orais e outros fármacos e 75% delas já experimentaram efeitos colaterais. Conclusão: Diante das informações apresentadas, conclui-se que é de grande importância que o conhecimento das usuárias de CHOs seja avaliado, tornando possível identificar quais as orientações e informações devem ser aplicadas de forma mais ampla, a fim de que esse fármaco seja utilizado corretamente. Considerando-se que estudantes da área da saúde serão futuros multiplicadores de conhecimento é essencial que estejam bem informadas.
Análise da viabilidade e relevância da inserção da disciplina de educação financeira nos cursos de formação da Polícia Militar do Estado do Paraná / Analysis of the feasibility and relevance of inserting the subject of financial education in the training courses of the Military Police of the State of Paraná
Authors: Barbosa Danilo Santana
Published: August 2022

O presente estudo aborda o tema educação financeira na PMPR, com o objetivo de analisar através de pesquisa bibliográfica a viabilidade e relevância da inserção desta temática nos bancos escolares dos cursos de formação da Instituição. A atualidade e emergência do tema no âmbito nacional é apresentada e justificada pelo cenário de recorde de famílias endividadas no Brasil, nesse contexto a educação financeira surge como importante ferramenta para criar no cidadão a consciência financeira necessária para uma boa gestão orçamentária. Assim, em atendimento à Estratégia Nacional de Educação Financeira, é fundamental que essa temática seja estimulada nos brasileiros, seja no ambiente familiar, escolar ou das organizações. Como conclusão, tem-se que a inserção financeira nos bancos escolares da PMPR poderá permitir que o militar estadual desenvolva interesse e habilidades para gerir seu orçamento e planejamento financeiro pessoal, contribuindo significativamente para que ele tenha uma vida financeira organizada e evite os malefícios que o estresse financeiro pode causar.
Levantamento do perfil clínico-epidemiológico dos pacientes críticos com Covid-19 de uma UTI em um hospital do interior de Rondônia / Survey of the clinical-epidemiological profile of critical patients with Covid-19 in an ICU in a hospital in the interior of Rondônia
Authors: Amaral Pâmella Polastry Braga , Da Silva Rittiela Rocha , De Oliveira Wuelison Lelis , De Carvalho Osdete Correa , De Souza Tiago Del Piero , Vieira Pâmela Angeli , Resende Treisy Cristhina Braga
Published: August 2022

As unidades de terapia intensiva (UTIs) são destinadas a cuidados mais complexos na área da saúde, ou seja, para pacientes que requerem assistência mais especializada e de forma contínua. Para que isso seja possível, faz-se uso de inúmeras tecnologias que contribuem com este processo. Em dezembro de 2019 em Whuan, na China, foi relatado sobre o surto infeccioso causado pelo SARS-CoV-2, popular coronavírus, agente causador da COVID-19, infecção caracterizada pela sua rápida disseminação entre humanos. Dentre os sintomas, cita-se: tosse seca, dor de cabeça, hipóxia, febre e dispneia. A nível metodológico, trata-se de uma pesquisa retrospectiva e descritiva, documental, de cunho qualitativo e quantitativo, levantando os perfis da amostra e também as variáveis que os diferem, e a incidência destas sobre a amostra pesquisada. A amostra que contemplou o estudo foi de 154 pacientes, sendo coletados dados em prontuários de forma secundária. No que se refere ao resultado do desfecho clínico, 33,1% dos pacientes evoluíram com alta da UTI, contra 66,8% que evoluíram para óbito. Foi possível observar a que a maior parte da amostra evoluiu para o óbito, dado presente em demais pesquisas relacionadas ao desfecho clínico de pacientes críticos com COVID-19. Conclui-se que o perfil predominante de pacientes críticos atingidos pela COVID-19 submetidos a intubação orotraqueal (IOT) foram em sua maioria pacientes do sexo masculino, idosos, que possuíam doença crônicas com maior predominância a hipertensão arterial e a diabetes mellitus.
A reeducação postural global como método terapêutico para o tratamento de Escoliose: revisão de literatura / Global postural re-education as a therapeutic method for the treatment of Scoliosis: a literature review
Authors: Araújo Ana Paula Barbosa de , Lima Damiana Nogueira , Araújo Carolina Fernandes , Oliveira Luiz Carlos Bezerra de , Silva Rose Cristiane Rocha da , Oliveira Bruna Michele de
Published: August 2022

Os métodos de reeducação postural global (RPG), têm sido usados na prática clínica na prevenção e restauração de doenças musculoesqueléticas e redução da escoliose. No processo de utilização do RPG, são utilizadas uma ou mais posturas que alongam gradativamente músculos específicos de uma determinada corrente e/ou cadeias estáticas secundárias. Objetivo: analisar a reeducação postural global como método terapêutico para o tratamento de escoliose. Metodologia: Esse trabalho trata-se de uma revisão de literatura, Scopus e Scientific Electronic Library Online (SCIELO), Literatura Latino-Americana e do Caribe em Ciências da Saúde (LILACS) e Biblioteca virtual da saúde (BVS). Resultado e Discussão: Este estudo demonstra que a abordagem RPG é uma ferramenta eficaz para promover a redução da escoliose. Conclusão: Os benefícios obtidos na literatura, pode-se observar a importância da fisioterapia utilizando RPG especificamente para o tratamento de pacientes com escoliose, outros pesquisadores devem continuar buscando conhecimento para descobrir mais benefícios do RPG no tratamento da escoliose.
UX Design - um guia prático para iniciantes
Authors: Dos Santos Brenda Carolina , Mauro Paulo Sergio Gaudencio , Ducatti José Alexandre , Souza Mariangela Catelani , Corrêa Lygia Aparecida das Graças Gonçalves , Da Silva Helber Mateus , De Queiroga Ana Paula Garrido , De Souza Valéria Signorini Bernardino
Published: August 2022

O presente trabalho contém as informações sobre ferramentas básicas que serão utilizadas na aplicação do conceito de User Experience Design (UX Design), seja qual for a área ou produto aplicado, para iniciantes no assunto e tão necessário para o mercado atual. Este artigo será um guia para o direcionamento e conhecimento da importância do aprofundamento de que é o cliente e como ele se comporta em relação ao consumo designado. Assim, o profissional que desejar melhorar a experiência positiva do seu usuário, conseguirá aprender e aplicar o processo.
Coinfecção de Dengue e H1N1: um relato de caso / Dengue and H1N1 coinfection: a case report
Authors: Pires Hudson Henrique Gomes , Borges Eduardo Pereira , Tibiletti Camila Ribeiro , Martins Beatriz Arfelli , Machado Guilherme Henrique , Carmargo Giovanine Pires de , Silverio Ana Carolina de Paula
Published: August 2022

Os autores trazem um relato e discussão, com embasamento em literatura, de um caso de um paciente com coinfecção de dengue e H1N1, admitido em unidade de terapia intensiva. Apresentava na admissão quadro de febre, tosse seca, prostração, mialgia, cefaleia, dispneia moderada e vômitos. Na dengue, o quadro clínico predominante se caracteriza por febre, erupção cutânea, dispneia, cefaleia e prostração. A infecção por H1N1 se caracteriza clinicamente por febre, tosse, dispneia e odinofagia. Nesse relato de caso o objetivo é se atentar para possibilidade de coinfecção pelas duas doenças, evidenciar a dificuldade de diagnóstico dessa coinfecção devido a sobreposição do quadro clínico, a fim de uma melhor condução terapêutica.
Abordagem terapêutica em mulheres com Vaginismo: revisão de literatura / Therapeutic approach in women with Vaginism: literature review
Authors: Amaral Letícia Luiza Miranda , Nascimento Júlia Sá , Silva Laura Rodrigues , Porto Luiza Lourensute , Valadão Analina Furtado , Pascoal Caroline Kíssila Pereira , Souza Lorena Miranda de
Published: August 2022

Introdução: o vaginismo é caracterizado por contrações involuntárias dos músculos do assoalho pélvico, que pode ocasionar redução da qualidade e satisfação nas relações sexuais, e consequentemente, predispor a diminuição do bem-estar das mulheres portadoras desse distúrbio doloroso. Experiências sexuais negativas, opressões, abuso e medos são alguns dos fatores que desencadeiam essa doença, sendo o tratamento individualizado, estabelecido por meio de uma equipe multidisciplinar e com múltiplas modalidades. Objetivo: revisar as modalidades terapêuticas utilizadas para o tratamento do vaginismo, descritas na literatura. Método: trata-se de uma revisão descritiva e exploratória de literatura. O levantamento de dados foi realizado por meio de pesquisas de artigos delimitados entre os anos de 2016 e 2021, indexados em bases de dados como, PubMed, Scielo, Cochrane Library e Elsevier. Desenvolvimento: o vaginismo é uma desordem de esfera dolorosa e emocional, caracterizada pelo receio quanto à penetração, devido à presença de desconforto durante o ato sexual. A epidemiologia acerca da dor gênito-pélvica ainda é muito escassa, e por mais difícil que seja avaliar a precisão da frequência, a grande maioria dos autores colocam entre 1% a 2% de ocorrência nas mulheres em contexto mundial. Dispareunia, desconforto, dor, ardência e medo são os sintomas mais relatados entre as mulheres com vaginismo. Após estabelecido o diagnóstico, deve ser definida uma equipe multidisciplinar para acompanhamento dessa paciente, visto que a melhor estratégia terapêutica é resultante de combinações de múltiplas modalidades. Intervenções fisioterapêuticas, terapia cognitiva- comportamental, eletroterapia, estímulo por biofeedback e aplicação de toxina botulínica estão entre as mais aplicadas segundo a literatura pesquisada. Conclusão: com essa revisão de literatura, conclui-se que existem várias modalidades terapêuticas utilizadas atualmente para o tratamento do vaginismo. Independente da causa dessa doença, é indispensável uma abordagem multidisciplinar e individualizada, levando em consideração que esse transtorno doloroso pode afetar a vida da paciente e de sua família em vários aspectos. É fundamental a disseminação de maiores informações acerca do vaginismo para que não seja tratado como tabu, a fim de facilitar o diagnóstico e tratamento dessas mulheres.
Remoção cirúrgica tardia de implante dentário deslocado para o interior do seio maxilar: relato de caso clínico / Delay surgical removal of dental implants displaced into the inside of the maxillary sinus: clinical case report
Authors: Borges Ana Beatriz Cruvinel , Fernandes Nikson Pereira , Barbosa Matheus Almeida , Petineli Isamara Rocha de Carvalho , Daniel Mailza Fernandes , Melo Lais de Oliveira , Sá Rodrigo Tavares de
Published: August 2022

A instalação de implantes dentários na região posterior da maxila é um procedimento relativamente simples, porém, necessita de uma avaliação e planejamento adequado, pois a região apresenta peculiaridades específicas, como baixa quantidade e qualidade óssea, sendo possível a presença de intercorrências no local. A falha em se obter a estabilidade primária pode ocasionar o deslocamento do implante para o interior do seio maxilar, podendo resultar em patologias sinusais, sendo necessário a remoção cirúrgica do implante deslocado. O objetivo desse trabalho é relatar um caso de remoção cirúrgica de um implante dentário no interior do seio maxilar pela técnica de Caldwell Luc. Paciente do gênero feminino, 41 anos de idade, compareceu a clínica integrada do Centro Universitário Sul-Americano (UNIFASAM) para a remoção de um implante dentário no interior do seio maxilar direito com um ano após a instalação na região do dente 15. Na anamnese, verificou-se que na cirurgia de reabertura do implante, após três meses de sua instalação, foi observado que o implante não se apresentava osseintegrado, sendo acidentalmente, deslocado para o interior da cavidade antral, confirmado por meio de radiografia periapical da região. Foi solicitado uma Tomografia Computadorizada de Feixe Cônico (TCCF), no qual pode-se confirmar a presença do implante na parede inferior do seio maxilar, com espessamento da membrana sinusal. O plano de tratamento foi a abordagem cirúrgica por meio do acesso de Caldwell Luc sob anestesia local e, posterior, remoção do corpo estranho. O deslocamento do implante dentário para o interior do seio maxilar é um acidente incomum na prática clínica, sendo fundamental a individualização de cada caso, com a finalidade de promover o melhor plano de tratamento para o paciente a fim de evitar ou minimizar as intercorrências.
Relação da influência parental no padrão alimentar das crianças atendidas no Instituto Servi / Relationship of parental influence on the dietary pattern of children assisted at Servi Institute
Authors: Moreira Neto Adalberto Alves , Ruiz Julia Alves , Da Luz Maíra Fontel , Bueno Claudia Dizioli Franco , Rabelo Lorena dos Reis , Da Cunha Maria Angélica Carneiro
Published: August 2022

A Alimentação é um dos principais fatores a serem considerados relevantes ao analisar a saúde de uma criança. Além disso, ainda reflete diversos aspectos socioculturais. O estudo objetivou compreender a influência parental no padrão alimentar das crianças atendidas no Instituto Servi, utilizando a amostragem de crianças de 6 meses a 1 ano 11 meses e 29 dias. Para alcançar o objetivo, foi realizado um estudo transversal e analítico por meio de aplicação de questionário com os pais/ responsáveis pela criança no momento da consulta. Os dados coletados no questionário foram tabulados no software editor de planilhas Microsoft Excel pela frequência das respostas obtidas. Desse modo, com amostra de 40 responsáveis com idade superior a 18 anos e IC 95%, o estudo demonstra claro padrão entre a alimentação infantil e a dos pais com coeficiente de correlação linear (r) de 0,8233 impondo, estatisticamente, correspondência muito alta entre os padrões alimentares. Houve clara prevalência de predileção por frutas e legumes por parte das crianças e os pais igualmente com adição da predileção as carnes. Logo, é imprescindível a promoção de mais pesquisas envolvendo a amostra pesquisada, bem como a consolidação de palestras e eventos acadêmicos que favoreçam um maior acesso dos pais a informações relativas a uma melhor conduta alimentar própria e de seus filhos.