bluuebunny/crossref_metadata_2025 huggingface dataset:
Thermo-optic tunable optical filters with GHz-bandwidth and flat-top passband on thin film lithium niobate platform
Authors: Ding Yuedi , Tao Shiqi , Wang Xuanhao , Shang Chenglin , Pan An , Zeng Cheng , Xia Jinsong
Published: May 2022

Lithium niobate on insulator (LNOI) is a new photonic integrated platform that provides high optical confinement and retains the inherent excellent properties of lithium niobate (LN). Tunable filters are one of the indispensable devices for integrated optics. Here we design and fabricate a thermo-optic (TO) tunable optical filter using two cascaded racetrack microring resonators (MRRs) based on LNOI. The filter shows a narrow and flat top passband with intra band ripple less than 0.3 dB, 3 dB bandwidth of 4.8 GHz and out-of-band rejection of about 35 dB. The insertion loss of the filter is about −14 dB, including grating coupling loss about −6.5 dB and on-chip loss less than −1 dB. The heating power for center wavelength shift of the filter is about 89.4 mW per free spectral range (FSR). Relevant applications of such filters include optical information processing and microwave photonics.
Stable single transverse mode excitation in 50 µm core fiber using a photonic-lantern-based adaptive control system
Authors: Lu Yao , Chen Zilun , Liu Wenguang , Jiang Man , Yang Junbo , Zhou Qiong , Zhang Jiangbin , Chai Junyu , Jiang Zongfu
Published: May 2022

We report on the generation of single transverse mode output in large-mode-area fiber with a core diameter of 50 µm using a 3×1 photonic-lantern-based adaptive spatial mode control system. We have designed and fabricated the photonic lantern composed of a single mode fibers bundle taper region and a multi-segment multimode fiber splicing region. From simulation and experiments, we demonstrate that the quality of the output beam is significantly influenced by the size of the fibers bundle’s waist and the segmented splicing scheme of the multimode fiber. Stable single transverse mode output is achieved at 1064 nm with M2 ∼1.4, which will provide a possible technical solution to increase the mode instability threshold in high power large-mode-area fiber systems.
Production of ultra-steep dichroic filters with broad band optical monitoring
Authors: Ji Xiaochuan , Zhang Jinlong , Jiao Hongfei , Cheng Xinbin , Wang Zhanshan , Kochikov Igor , Sharov Alexander , Tikhonravov Alexander
Published: May 2022

The feasibility of using direct broad band optical monitoring control in the fabrication of the ultra-steep dichroic filters based on resonant structures is investigated. Using computational manufacturing and deposition experiments, the role of the errors self-compensation effect is clarified by comparing the results of direct broad band optical monitoring and time monitoring. The errors correlation strength of ultra-steep dichroic filter is analyzed and it shows that the correlation calculated by the current model is not strong. The relationship between errors correlation and errors self-compensation effect for the ultra-steep dichroic filter is discussed.
Exploring the influence of pump beam quality on designing millijoule diode-end-pumped passively Q-switched lasers
Authors: Cho Chun-Yu , Lin Xin-Cheng , Shr Je-Hau
Published: May 2022

To practically predict the design criteria of diode-end-pumped passively Q-switched (PQS) lasers with energy scaling to millijoule region, an analytical model with longitudinally spatial dependence is derived to investigate the influence of pump beam quality. In comparison with PQS theory that considers transverse spatial dependence only, it is found that the threshold pump power can be up to 5 times larger when the beam quality factor was 80. This result indicates the importance of considering pump beam quality when designing PQS lasers especially for operation at high pump power level. The theoretical results are verified by a series of PQS experiments. The influence of thermal lensing effect on cavity design is further discussed to obtain good laser quality. Finally, an end-pumped millijoule PQS laser is successfully realized based on the theoretical analysis and the resonator design.
Dual-band giant spin-selective full-dimensional manipulation of graphene-based chiral meta-mirrors for terahertz waves
Authors: Li Hui , Li Jie , Zheng Chenglong , Xu Hang , Yang Fan , Li Jitao , Yue Zhen , Shi Wei , Zhang Yating , Yao Jianquan
Published: May 2022

The ability to simultaneous achieve circular dichroism (CD) and wavefront manipulation is extremely important for many practical applications, especially for detecting and imaging. However, many of the previously observed weakness chiral features are limited to nanostructures with complex three-dimensional building configurations, single narrow-band response, and no active tunability, which are getting farther and away from the goal of integration and miniaturization. Here, a platform of bi-layer all-graphene meta-mirrors with spin-selective full-dimensional manipulation is proposed to simultaneously achieve giant dual-band CD response and wavefront shaping, based on the principle of the hybridization coupling. By simply controlling the structural variables of the meta-mirror and the characteristic parameters of graphene, that is, the combination of passive and active regulation, the proposed design can selectively manipulate the polarization, amplitude, phase, and working frequency of the incident circularly polarized wave near-independently. As a proof of concept, we used the meta-mirror to design two metasurface arrays with spin-selective properties for dynamic terahertz (THz) wavefront shaping and near-field digital imaging, both of which show a high-performance dynamic tunability. This method could provide additional options for the next-generation intelligent THz communication systems.
Verbesserte Patientenversorgung und effizientere Zusammenarbeit zwischen Apotheken und Pflegediensten durch maschinelle Medikamentenverblisterung und die Vernetzungsplattform MediMan: Eine Fallstudie
Authors: Kajüter Patricia , Behne Alina , Teuteberg Frank
Published: May 2022

Pflegebedürftige können ihre Medikamente oft nicht selbstständig stellen, deshalb wird dies durch geschultes Fachpersonal ambulanter Pflegedienste übernommen. Dieser Prozess ist fehleranfällig, denn die Medikamente werden häufig manuell und in der Nachtschicht vom Pflegefachpersonal zusammengestellt. Hierdurch kann es zu Risiken wie Doppelmedikationen und unberücksichtigten Wechselwirkungen unterschiedlicher Medikamente kommen. Zudem ist dieser Prozess nicht ressourceneffizient und durch den bereits bestehenden Fachkräftemangel nicht tragbar. Durch die vergleichsweise geringe digitale Vernetzung im deutschen Gesundheitswesen gibt es bei der interprofessionellen Zusammenarbeit zwischen Apotheken, Pflegediensten, Blisterzentren und Arztpraxen weiteren Verbesserungsbedarf. Ziel dieses Beitrags ist es daher aufzuzeigen, welche Erkenntnisse und Handlungsbereiche sich aus einer Fallstudie zur digitalen Vernetzungsplattform MediMan ableiten lassen und wie in diesem Zusammenhang die maschinelle Medikamentenverblisterung dazu beitragen kann, die interprofessionelle Zusammenarbeit zwischen Apotheken, Pflegediensten, Blisterzentren und Arztpraxen durch eine sichere und effiziente Patientenversorgung zu führen. Anhand einer Prozessmodellierung, basierend auf Experteninterviews und Fokusgruppen mit Stakeholdern aus dem Gesundheitswesen, wird aufgezeigt, welche Potenziale sich aus der maschinellen Verblisterung in Kombination mit einer Vernetzungsplattform ergeben. Als Ergebnis lassen sich acht Erkenntnisse bzw. Handlungsbereiche ableiten, die in diesem Beitrag vertiefend vorgestellt werden: (1) Prozessvereinfachung, (2) Plattformerprobung, (3) Abstimmungsbedarfe, (4) Mitarbeitereinbindung und -schulung, (5) Informationsverbreitung, (6) Vergütungsregelungen, (7) Schnittstelle Warenwirtschaftssystem sowie (8) Interoperabilität und Telematikinfrastruktur.
Neural networks enable efficient and accurate simulation-based inference of evolutionary parameters from adaptation dynamics
Authors: Avecilla Grace , Chuong Julie N. , Li Fangfei , Sherlock Gavin , Gresham David , Ram Yoav
Published: May 2022

The rate of adaptive evolution depends on the rate at which beneficial mutations are introduced into a population and the fitness effects of those mutations. The rate of beneficial mutations and their expected fitness effects is often difficult to empirically quantify. As these 2 parameters determine the pace of evolutionary change in a population, the dynamics of adaptive evolution may enable inference of their values. Copy number variants (CNVs) are a pervasive source of heritable variation that can facilitate rapid adaptive evolution. Previously, we developed a locus-specific fluorescent CNV reporter to quantify CNV dynamics in evolving populations maintained in nutrient-limiting conditions using chemostats. Here, we use CNV adaptation dynamics to estimate the rate at which beneficial CNVs are introduced through de novo mutation and their fitness effects using simulation-based likelihood–free inference approaches. We tested the suitability of 2 evolutionary models: a standard Wright–Fisher model and a chemostat model. We evaluated 2 likelihood-free inference algorithms: the well-established Approximate Bayesian Computation with Sequential Monte Carlo (ABC-SMC) algorithm, and the recently developed Neural Posterior Estimation (NPE) algorithm, which applies an artificial neural network to directly estimate the posterior distribution. By systematically evaluating the suitability of different inference methods and models, we show that NPE has several advantages over ABC-SMC and that a Wright–Fisher evolutionary model suffices in most cases. Using our validated inference framework, we estimate the CNV formation rate at the GAP1 locus in the yeast Saccharomyces cerevisiae to be 10−4.7 to 10−4 CNVs per cell division and a fitness coefficient of 0.04 to 0.1 per generation for GAP1 CNVs in glutamine-limited chemostats. We experimentally validated our inference-based estimates using 2 distinct experimental methods—barcode lineage tracking and pairwise fitness assays—which provide independent confirmation of the accuracy of our approach. Our results are consistent with a beneficial CNV supply rate that is 10-fold greater than the estimated rates of beneficial single-nucleotide mutations, explaining the outsized importance of CNVs in rapid adaptive evolution. More generally, our study demonstrates the utility of novel neural network–based likelihood–free inference methods for inferring the rates and effects of evolutionary processes from empirical data with possible applications ranging from tumor to viral evolution.
Uncertainty–guided learning with scaled prediction errors in the basal ganglia
Authors: Möller Moritz , Manohar Sanjay , Bogacz Rafal
Published: May 2022

To accurately predict rewards associated with states or actions, the variability of observations has to be taken into account. In particular, when the observations are noisy, the individual rewards should have less influence on tracking of average reward, and the estimate of the mean reward should be updated to a smaller extent after each observation. However, it is not known how the magnitude of the observation noise might be tracked and used to control prediction updates in the brain reward system. Here, we introduce a new model that uses simple, tractable learning rules that track the mean and standard deviation of reward, and leverages prediction errors scaled by uncertainty as the central feedback signal. We show that the new model has an advantage over conventional reinforcement learning models in a value tracking task, and approaches a theoretic limit of performance provided by the Kalman filter. Further, we propose a possible biological implementation of the model in the basal ganglia circuit. In the proposed network, dopaminergic neurons encode reward prediction errors scaled by standard deviation of rewards. We show that such scaling may arise if the striatal neurons learn the standard deviation of rewards and modulate the activity of dopaminergic neurons. The model is consistent with experimental findings concerning dopamine prediction error scaling relative to reward magnitude, and with many features of striatal plasticity. Our results span across the levels of implementation, algorithm, and computation, and might have important implications for understanding the dopaminergic prediction error signal and its relation to adaptive and effective learning.
Discovering sparse control strategies in neural activity
Authors: Lee Edward D. , Chen Xiaowen , Daniels Bryan C.
Published: May 2022

Biological circuits such as neural or gene regulation networks use internal states to map sensory input to an adaptive repertoire of behavior. Characterizing this mapping is a major challenge for systems biology. Though experiments that probe internal states are developing rapidly, organismal complexity presents a fundamental obstacle given the many possible ways internal states could map to behavior. Using C. elegans as an example, we propose a protocol for systematic perturbation of neural states that limits experimental complexity and could eventually help characterize collective aspects of the neural-behavioral map. We consider experimentally motivated small perturbations—ones that are most likely to preserve natural dynamics and are closer to internal control mechanisms—to neural states and their impact on collective neural activity. Then, we connect such perturbations to the local information geometry of collective statistics, which can be fully characterized using pairwise perturbations. Applying the protocol to a minimal model of C. elegans neural activity, we find that collective neural statistics are most sensitive to a few principal perturbative modes. Dominant eigenvalues decay initially as a power law, unveiling a hierarchy that arises from variation in individual neural activity and pairwise interactions. Highest-ranking modes tend to be dominated by a few, “pivotal” neurons that account for most of the system’s sensitivity, suggesting a sparse mechanism of collective control.
Daf-16 mediated repression of cytosolic ribosomal protein genes facilitates a hypoxia sensitive to hypoxia resistant transformation in long-lived germline mutants
Authors: Hemphill Cassidy , Pylarinou-Sinclair Evye , Itani Omar , Scott Barbara , Crowder C. Michael , Van Gilst Marc Ryan
Published: May 2022

In C. elegans, germline ablation leads to long life span and stress resistance. It has been reported that mutations that block oogenesis or an upstream step in germline development confer strong resistance to hypoxia. We demonstrate here that the hypoxia resistance of sterile mutants is dependent on developmental stage and age. In just a 12-hour period, sterile animals transform from hypoxia sensitive L4 larvae into hypoxia resistant adults. Since this transformation occurs in animals with no germline, the physiological programs that determine hypoxia sensitivity in germline mutants occur independently of germline signals and instead rely on signals from somatic tissues. Furthermore, we found two distinct mechanisms of hypoxia resistance in germline deficient animals. First, a DAF-16/FoxO independent mechanism that occurs in all hypoxia resistant sterile adults and, second, a DAF-16/FoxO dependent mechanism that confers an added layer of resistance, or “super-resistance”, to animals with no germline as they age past day 1 of adulthood. RNAseq data showed that genes involved in both cytosolic and mitochondrial protein translation are repressed in sterile adults and further repressed only in germline deficient mutants as they age. Importantly, mutation of daf-16 specifically blocked the repression of cytosolic ribosomal protein genes, but not mitochondrial ribosomal protein genes, implicating DAF-16/FoxO mediated repression of cytosolic ribosomal protein genes as a mechanism of hypoxia super-resistance. Consistent with this hypothesis, the hypoxia super-resistance of aging germline deficient adults was also suppressed by dual mutation of ncl-1 and larp-1, two regulators of protein translation and ribosomal protein abundance. These studies provide novel insight into a profound physiological transformation that takes place in germline mutants during development, showing that some of the unique physiological properties of these long-lived animals are derived from developmentally dependent DAF-16/FoxO mediated repression of genes involved in cytosolic protein translation.
Production of 3′,3′-cGAMP by a Bdellovibrio bacteriovorus promiscuous GGDEF enzyme, Bd0367, regulates exit from prey by gliding motility
Authors: Lowry Rebecca C. , Hallberg Zachary F. , Till Rob , Simons Tyler J. , Nottingham Ruth , Want Fiona , Sockett R. Elizabeth , Hammond Ming C. , Lambert Carey
Published: May 2022

Bacterial second messengers are important for regulating diverse bacterial lifestyles. Cyclic di-GMP (c-di-GMP) is produced by diguanylate cyclase enzymes, named GGDEF proteins, which are widespread across bacteria. Recently, hybrid promiscuous (Hypr) GGDEF proteins have been described in some bacteria, which produce both c-di-GMP and a more recently identified bacterial second messenger, 3′,3′-cyclic-GMP-AMP (cGAMP). One of these proteins was found in the predatory Bdellovibrio bacteriovorus, Bd0367. The bd0367 GGDEF gene deletion strain was found to enter prey cells, but was incapable of leaving exhausted prey remnants via gliding motility on a solid surface once predator cell division was complete. However, it was unclear which signal regulated this process. We show that cGAMP signalling is active within B. bacteriovorus and that, in addition to producing c-di-GMP and some c-di-AMP, Bd0367 is a primary producer of cGAMP in vivo. Site-directed mutagenesis of serine 214 to an aspartate rendered Bd0367 into primarily a c-di-GMP synthase. B. bacteriovorus strain bd0367S214D phenocopies the bd0367 deletion strain by being unable to glide on a solid surface, leading to an inability of new progeny to exit from prey cells post-replication. Thus, this process is regulated by cGAMP. Deletion of bd0367 was also found to be incompatible with wild-type flagellar biogenesis, as a result of an acquired mutation in flagellin chaperone gene homologue fliS, implicating c-di-GMP in regulation of swimming motility. Thus the single Bd0367 enzyme produces two secondary messengers by action of the same GGDEF domain, the first reported example of a synthase that regulates multiple second messengers in vivo. Unlike roles of these signalling molecules in other bacteria, these signal to two separate motility systems, gliding and flagellar, which are essential for completion of the bacterial predation cycle and prey exit by B. bacteriovorus.
Investigation of an outbreak of COVID-19 among U.S. military personnel and beneficiaries stationed in the Republic of Korea, June-July 2021
Authors: Hakre Shilpa , Lam Evelyn Y. , Maljkovic-Berry Irina , Hang Jun , Pow Sang Luis A. , Bianchi Elizabeth J. , Fung Christian , Gandhi Jay , Chibucos Marcus , Conte Matthew A. , Pollio Adam R. , Mariskanish Christine A. , Mansfield Luke A. , Modjarrad Kayvon , Friberg-Robertson Heather L. , Lidl Grace M. , Scott Paul T. , Lougee Douglas A.
Published: May 2022

On 28 May 2021, leisure travel restrictions in place to control coronavirus disease 2019 (COVID-19) were eased among vaccinated U.S. military personnel and beneficiaries stationed in South Korea (USFK) allowing access to bars and clubs which were off limits. We describe results from an investigation of the largest severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreak as of November 2021 among USFK personnel following this change in policy. Data such as SARS-CoV-2 real-time polymerase chain reaction (RT-PCR) test results, demographic characteristics, symptom and vaccination histories, and genome sequences were analyzed. Of a total 207 new cases of COVID-19 diagnosed among USFK members from 15 June to 27 July 2021, 113 (57%) eligible cases were fully vaccinated, of whom 86 (76%) were symptomatic. RT-PCR cycling threshold values were similar among vaccinated and unvaccinated members. Whole genomic sequencing of 54 outbreak samples indicated all infections were due to the Delta variant. Phylogenetic analysis revealed two sources of SARS-CoV-2 accounted for 41% of infections among vaccinated and unvaccinated members. Vaccinated personnel were not at risk of severe illness; however, 86% experienced symptoms following infection. There were no hospitalizations among COVID-19 cases, most of whom were young military service members. Rescinded restrictions were reinstated to control the outbreak. Masking was mandated among all personnel predating U.S. national recommendations for indoor masking in high COVID-19 transmission areas. Increased vaccination with continued vigilance and extension of COVID-19 mitigation measures are warranted to contain the spread of SARS-CoV-2 variants of concern.
A highly attenuated Vesiculovax vaccine rapidly protects nonhuman primates against lethal Marburg virus challenge
Authors: Woolsey Courtney , Cross Robert W. , Agans Krystle N. , Borisevich Viktoriya , Deer Daniel J. , Geisbert Joan B. , Gerardi Cheryl , Latham Theresa E. , Fenton Karla A. , Egan Michael A. , Eldridge John H. , Geisbert Thomas W. , Matassov Demetrius
Published: May 2022

Background

Marburg virus (MARV), an Ebola-like virus, remains an eminent threat to public health as demonstrated by its high associated mortality rate (23–90%) and recent emergence in West Africa for the first time. Although a recombinant vesicular stomatitis virus (rVSV)-based vaccine (Ervebo) is licensed for Ebola virus disease (EVD), no approved countermeasures exist against MARV. Results from clinical trials indicate Ervebo prevents EVD in 97.5–100% of vaccinees 10 days onwards post-immunization.

Methodology/Findings

Given the rapid immunogenicity of the Ervebo platform against EVD, we tested whether a similar, but highly attenuated, rVSV-based Vesiculovax vector expressing the glycoprotein (GP) of MARV (rVSV-N4CT1-MARV-GP) could provide swift protection against Marburg virus disease (MVD). Here, groups of cynomolgus monkeys were vaccinated 7, 5, or 3 days before exposure to a lethal dose of MARV (Angola variant). All subjects (100%) immunized one week prior to challenge survived; 80% and 20% of subjects survived when vaccinated 5- and 3-days pre-exposure, respectively. Lethality was associated with higher viral load and sustained innate immunity transcriptional signatures, whereas survival correlated with development of MARV GP-specific antibodies and early expression of predicted NK cell-, B-cell-, and cytotoxic T-cell-type quantities.

Conclusions/Significance

These results emphasize the utility of Vesiculovax vaccines for MVD outbreak management. The highly attenuated nature of rVSV-N4CT1 vaccines, which are clinically safe in humans, may be preferable to vaccines based on the same platform as Ervebo (rVSV “delta G” platform), which in some trial participants induced vaccine-related adverse events in association with viral replication including arthralgia/arthritis, dermatitis, and cutaneous vasculitis.
Performance of a rapid immuno-chromatographic test (Schistosoma ICT IgG-IgM) for detecting Schistosoma-specific antibodies in sera of endemic and non-endemic populations
Authors: Hoermann Julie , Kuenzli Esther , Schaefer Carmen , Paris Daniel H. , Bühler Silja , Odermatt Peter , Sayasone Somphou , Neumayr Andreas , Nickel Beatrice
Published: May 2022

Background

Schistosomiasis, an acute and chronic parasitic disease caused by human pathogenic Schistosoma species, is a neglected tropical disease affecting more than 220 million people worldwide.

For diagnosis of schistosomiasis, stool and urine microscopy for egg detection is still the recommended method, however sensitivity of these methods is limited. Therefore, other methods like molecular detection of DNA in stool, detection of circulating cathodic antigen in urine or circulating anodic antigen in urine and serum, as well as serological tests have gained more attention. This study examines the sensitivity and specificity of a rapid diagnostic test based on immunochromatography (Schistosoma ICT IgG-IgM, LD Bio, Lyon, France) for simultaneous detection of specific IgG and IgM antibodies in serum, against Schistosoma spp. in endemic and non-endemic populations.

Methodology/Principal findings

Frozen banked serum samples from patients with confirmed schistosomiasis, patients with other helminth infections, patients with seropositive rheumatoid arthritis and healthy blood donors were used to assess the sensitivity and the specificity of the Schistosoma ICT IgG-IgM rapid diagnostic test.

The test showed a sensitivity of 100% in patients with parasitologically confirmed schistosomiasis, irrespective of the species (S. mansoni, S. haematobium, S. japonicum, S. mekongi). In healthy blood donors and patients with rheumatoid factor positive rheumatoid arthritis from Europe, specificity was 100%. However, in serum samples of patients with other tissue invasive helminth infections, the test showed some cross-reactivity, resulting in a specificity of 85%.

Conclusion/Significance

With its high sensitivity, the Schistosoma ICT IgG-IgM rapid diagnostic test is a suitable screening test for detection of Schistosoma specific antibodies, including S. mekongi. However, in populations with a high prevalence of co-infection with other tissue invasive helminths, positive results should be confirmed with other diagnostic assays due to the test’s imperfect specificity.
The genetic diversity of Ethiopian barley genotypes in relation to their geographical origin
Authors: Teklemariam Surafel Shibru , Bayissa Kefyalew Negisho , Matros Andrea , Pillen Klaus , Ordon Frank , Wehner Gwendolin
Published: May 2022

Ethiopia is recognized as a center of diversity for barley, and its landraces are known for the distinct genetic features compared to other barley collections. The genetic diversity of Ethiopian barley likely results from the highly diverse topography, altitude, climate conditions, soil types, and farming systems. To get detailed information on the genetic diversity a panel of 260 accessions, comprising 239 landraces and 21 barley breeding lines, obtained from the Ethiopian biodiversity institute (EBI) and the national barley improvement program, respectively were studied for their genetic diversity using the 50k iSelect single nucleotide polymorphism (SNP) array. A total of 983 highly informative SNP markers were used for structure and diversity analysis. Three genetically distinct clusters were obtained from the structure analysis comprising 80, 71, and 109 accessions, respectively. Analysis of molecular variance (AMOVA) revealed the presence of higher genetic variation (89%) within the clusters than between the clusters (11%), with moderate genetic differentiation (PhiPT = 0.11) and five accessions were detected as first-generation migrants using Monte Carlo resampling methods. The Mantel test revealed that the genetic distance between accessions is poorly associated with their geographical distance. Despite the observed weak correlation between geographic distance and genetic differentiation, for some regions like Gonder, Jimma, Gamo-Gofa, Shewa, and Welo, more than 50% of the landraces derived from these regions are assigned to one of the three clusters.
Psychological impact of the COVID-19 epidemic among healthcare workers in paediatric intensive care units in China
Authors: Zhang Yue , Pi Dan-Dan , Liu Cheng-Jun , Li Jing , Xu Feng
Published: May 2022

To perform a mental health evaluation and an early psychological intervention for healthcare workers (HCWs) during the coronavirus disease 2019 (COVID-19) epidemic, an online survey was conducted among 3055 HCWs in the paediatric intensive care units (PICUs) of 62 hospitals in China on March 26, 2020, by the Neurology and Sedation Professional Group, Emergency Department, Paediatrics Branch, Chinese Medical Association. The questionnaire was divided into three parts, including general information, the Impact of Event Scale-Revised (IES-R), and the Depression Anxiety Stress Scale-21 (DASS-21). The results show that a total of 970 HCWs (45.99%) were considered to meet the clinical cut-off scores for posttraumatic stress (PTS), and the proportions of participants with mild to extremely severe symptoms of depression, anxiety and stress were 39.69%, 36.46% and 17.12%, respectively. There was no significant difference in the psychological impact among HCWs of different genders. Married HCWs were 1.48 times more likely to have PTS than unmarried HCWs (95% Cl: 1.20–1.82, p <0.001). Compared with junior professional title participants, the PTS-positive rate of HCWs with intermediate professional titles was 1.91 times higher (90% Cl: 1.35–2.70, p<0.01). Those who had been in contact with confirmed COVID-19 cases were 1.40 times (95% Cl: 1.02–1.92, p <0.05) more likely to have PTS than those who did not have contact with COVID-19 cases or did not know the relevant conditions. For depression, the proportion of HCWs with intermediate professional titles was significantly higher, at 1.65 times (90% Cl: 1.17–2.33, p <0.01) that of those with junior professional titles. The depression of HCWs at work during the epidemic was 1.56 times that of HCWs on vacation (95% Cl: 1.03–2.37, p <0.05), and their anxiety was 1.70 times greater (95% Cl: 1.10–2.63, p <0.05). Participants who had been in contact with confirmed COVID-19 cases had more pronounced anxiety, 1.40 times that of those who did not have contact with COVID-19 cases or did not know the relevant conditions (95% Cl: 1.02–1.92, p <0.05). There was no significant correlation between the variables and the positive results of stress symptoms. In total, 45.99%, 39.69%, 36.46% and 17.12% of PICU HCWs were affected by PTS, depression, anxiety and stress, respectively, to varying degree. Married status, intermediate professional titles and exposure history were independent risk factors for PTS. Intermediate professional titles and going to work during the epidemic were independent risk factors for depression, and going to work and exposure history during the epidemic were independent risk factors for anxiety. In the face of public health emergencies, HCWs not only specialize in paediatric intensive care but also, as a high-risk group, must actively take preventive measures and use mitigation strategies.
A new extended gumbel distribution: Properties and application
Authors: Fayomi Aisha , Khan Sadaf , Tahir Muhammad Hussain , Algarni Ali , Jamal Farrukh , Abu-Shanab Reman
Published: May 2022

A robust generalisation of the Gumbel distribution is proposed in this article. This family of distributions is based on the T-X paradigm. From a list of special distributions that have evolved as a result of this family, three separate models are also mentioned in this article. A linear combination of generalised exponential distributions can be used to characterise the density of a new family, which is critical in assessing some of the family’s properties. The statistical features of this family are determined, including exact formulations for the quantile function, ordinary and incomplete moments, generating function, and order statistics. The model parameters are estimated using the maximum likelihood method. Further, one of the unique models has been systematically studied. Along with conventional skewness measures, MacGillivray skewness is also used to quantify the skewness measure. The new probability distribution also enables us to determine certain critical risk indicators, both numerically and graphically. We use a simulated assessment of the suggested distribution, as well as apply three real-world data sets in modelling the proposed model, in order to ensure its authenticity and superiority.
Dynamic distribution and prevention of spontaneous combustion of coal in gob-side entry retaining goaf
Authors: Hu Dongjie , Li Zongxiang
Published: May 2022

The 11101 working face of Qipanjing Mine was taken as the research object to explore the dynamic change law of the spontaneous combustion of the remaining coal in the gob-side entry retaining goaf area. A sealed oxygen consumption experiment was conducted to determine the (critical) oxygen volume fraction in the suffocation zone and continuous oxygen consumption rate of coal samples. The parameters of the working face were measured on site, and the air volume fraction in the goaf was monitored using a beam tube. Considering upward ventilation and the effect of gravity, a UDF control program for the falling medium in the gob-side entry retaining goaf was written. Based on the experimental results, a control program for the continuous oxygen consumption rate of the remnant coal was compiled, the dynamic distribution of the flow field in the gob-side entry retaining goaf was simulated with different advancing positions and air leakage at the working face, and a prediction model for the spontaneous combustion danger area was established. Finally, fire prevention measures via grouting in the return air lane side and nitrogen injection in the retaining lane side were put forward. The results showed that with the variation in the advancing position of the working face or in the air leakage of the air intake lane, the range of the natural hazardous area of the gob-side entry retaining goaf presents a distribution with a power functionSF=xn+b(0 <n< 1). The theoretically proposed fire-fighting measures can effectively reduce the risk of spontaneous combustion of coal.
The efficacy of oxidized regenerated cellulose (SurgiGuard®) in breast cancer patients who undergo total mastectomy with node surgery: A prospective randomized study in 94 patients
Authors: Nam Kug Hyun , Lee Joon-Hyop , Chung Yoo Seung , Chun Yong Soon , Park Heung Kyu , Kim Yun Yeong
Published: May 2022

Background

Seromas frequently develop in patients who undergo total mastectomy with node surgery. We aimed to prospectively explore whether use of oxidized regenerated cellulose (ORC, SurgiGuard®) affects seroma formation after total mastectomy with node surgery (sentinel lymph node biopsy (SLNB) or axillary lymph node dissection (ALND)).

Materials and methods

Ninety four breast cancer patients were enrolled in the study who underwent total mastectomy with ALND or SLNB. The patients were randomized into two groups, one treated with ORC plus closed suction drainage and the other with closed suction drainage alone.

Results

Mean drainage volume was slightly lower in the ORC group on postoperative day 1 (123 ± 54 vs 143 ± 104 ml), but was slightly higher at all other time points; however, these differences were not significant. Mean total drainage volume in patients treated with ORC plus drainage did not differ from that of patients treated with drainage alone (1134 ± 507 ml vs 1033 ± 643 ml, P = 0.486).

Conclusions

Use of ORC (SurgiGuard®) did not significantly alter the risk of seroma formation.
A qualitative analysis of electronic nicotine delivery systems (ENDS) uptake and use among young adult never-smokers in New Zealand
Authors: Robertson Lindsay , Hoek Janet , Blank Mei-Ling
Published: May 2022

Introduction

Electronic nicotine delivery systems (ENDS) likely pose fewer health risks than smoking. Yet ENDS uptake has increased among never-smoking young adults, who likely face greater health risks relative to non-users of ENDS. To date, few qualitative studies have explored ENDS uptake and use by never-smokers.

Methods

We conducted in-depth, semi-structured interviews with 16 current ENDS users from New Zealand aged 18 to 24 years old who reported never having smoked cigarettes regularly. We explored participants’ experimentation with conventional tobacco products, trial, uptake and patterns of ENDS use, and their future intentions regarding both ENDS and conventional tobacco products. We managed the data using NVivo12 and used thematic analysis to interpret the transcripts.

Results

ENDS use enhanced connection and belonging by providing communal experiences and facilitating social interactions. Participants’ mastery of tricks generated social cachet within friendship groups and counteracted the ENDS-related stigma they experienced. Flavours, clouds and devices’ physical attributes provided stimulation and engagement, and some used ENDS for stress or appetite management. Lastly, participants rationalised ENDS uptake by referencing the far greater risks smoking posed.

Conclusions

ENDS uptake by young adult never-smokers is driven by both psycho-social and functional factors. ENDS provided shared hedonic experiences and physical pleasures, and generated both bonding and bridging social capital, although many participants had also experienced judgement from others for using ENDS. Policies that denormalise ENDS as recreational devices could discourage uptake by never-smokers, though measures will require careful nuancing to avoid deterring smokers from switching to ENDS.
Implementation of the ERAS (Enhanced Recovery After Surgery) protocol for hysterectomy in the Piedmont Region with an audit&feedback approach: Study protocol for a stepped wedge cluster randomized controlled trial. A study of the EASY-NET project
Authors: Piovano Elisa , Pagano Eva , Del Piano Elena , Rinaldi Federica , Palazzo Valentina , Coata Paola , Bongiovanni Daria , Rolfo Monica , Ceretto Giannone Laura , Veliaj Deliana , Camanni Marco , Puppo Andrea , Ciccone Giovannino ,   the ERAS-Gyneco Piemonte group
Published: May 2022

Introduction

ERAS (Enhanced Recovery After Surgery) is a perioperative program combining multiple evidence-based interventions designed to reduce the surgical stress response. Despite the publication of dedicated guidelines, ERAS application to gynecologic surgery outside clinical studies has been slow and fragmented. To promote the systematic adoption of the ERAS program in the entire regional hospital network in Piedmont an Audit-and-Feedback approach (A&F) has been adopted within a cluster randomized controlled trial, aiming to estimate the true impact of the protocol on a large, unselected population.

Methods

The study protocol provides for a multicenter stepped wedge cluster randomized trial, focused on women undergoing an hysterectomy, for comparison between standard perioperative management and perioperative management according to the ERAS protocol. The primary outcome is the length of hospital stay (LOS). Secondary outcomes are: post-operative complications, quality-of-recovery at 24-hours after surgery, 30-day readmissions, patients’ satisfaction, healthcare costs. The compliance to all the ERAS items is monitored with an A&F approach. All the gynecologic units of Piedmont hospitals are involved and all the patients hospitalized for elective hysterectomy in the period of the study are included. Centers, stratified by surgical volume and randomly assigned to four groups, are randomly ordered to activate the ERAS protocol in four periods, every three months. The planned calendar and the total duration of the study have been extended for six months due to the COVID-19 pandemic. The expected sample size of about 2400 patients has a high statistical power (99%) to detect a reduction of LOS of 1 day (effect size 0.5) and to estimate clinically meaningful changes in the other study endpoints. The study protocol has been approved by the Ethical Committee of all participating centers. Study results will be timely circulated within the hospital network and published in peer-reviewed journals.

Conclusion

Results are expected to demonstrate positive clinical outcomes of the ERAS protocol even when its implementation is directed towards an entire regional network of gynecologic units, and not only towards selected and highly motivated centers.

Trial registration

NCT04063072
Incidence and survival in laryngeal and lung cancers in Finland and Sweden through a half century
Authors: Koskinen Anni , Hemminki Otto , Försti Asta , Hemminki Kari
Published: May 2022

Global survival studies have shown favorable development in most cancers but few studies have considered laryngeal cancer, particularly over extended periods or in populations for which medical care is essentially free of charge. We analyzed laryngeal and lung cancer incidence and survival in Finland (FI) and Sweden (SE) over a 50-year period (1970–2019) using data and statistical tools from the Nordcan database. Laryngeal cancer reached an incidence maximum in FI men in 1965, which in SE men occurred over 10 years later and peaking at 42% of the FI maximum. The FI incidence halved in 20 years while halving of the SE rate took almost twice as long. At maximum the male rate exceeded the female rate 20 times in FI and 10 times in SE. Incidence rates for lung cancer were approximately 10 times higher than those for laryngeal cancer, and they peaked 5 to 10 years after laryngeal cancer in both countries. The female lung cancer rates increased through the follow-up time but laryngeal cancer rates were relatively stable. Relative 1-year survival data for laryngeal cancer remained at around 85% through 50 years, and 5-year survival lagged constantly around 65%. For lung cancer 1-year survival improved and reached about 50% by 2019. Even 5-year survival improved reaching 20 to 30%, except for FI men. Incidence rates for laryngeal and lung cancers have drastically decreased in FI and SE men parallel to reduced smoking prevalence. In females, rates have clearly increased in lung but not in FI laryngeal cancer. This finding warrants further investigations into possible contributing factors, other than smoking. Survival in laryngeal cancer has not improved compared to the positive development in lung cancer. Historical smoking prevalence was unrelated of survival trends. As long-term survival in these cancers remains discouraging, the most efficient way to fight them is to target the main cause and promote non-smoking.
Transfer learning-based channel estimation in orthogonal frequency division multiplexing systems using data-nulling superimposed pilots
Authors: Qing Chaojin , Dong Lei , Wang Li , Ling Guowei , Wang Jiafan
Published: May 2022

Data-nulling superimposed pilot (DNSP) effectively alleviates the superimposed interference of superimposed training (ST)-based channel estimation (CE) in orthogonal frequency division multiplexing (OFDM) systems, while facing the challenges of the estimation accuracy and computational complexity. By developing the promising solutions of deep learning (DL) in the physical layer of wireless communication, we fuse the DNSP and DL to tackle these challenges in this paper. Nevertheless, due to the changes of wireless scenarios, the model mismatch of DL leads to the performance degradation of CE, and thus faces the issue of network retraining. To address this issue, a lightweight transfer learning (TL) network is further proposed for the DL-based DNSP scheme, and thus structures a TL-based CE in OFDM systems. Specifically, based on the linear receiver, the least squares estimation is first employed to extract the initial features of CE. With the extracted features, we develop a convolutional neural network (CNN) to fuse the solutions of DL-based CE and the CE of DNSP. Finally, a lightweight TL network is constructed to address the model mismatch. To this end, a novel CE network for the DNSP scheme in OFDM systems is structured, which improves its estimation accuracy and alleviates the model mismatch. The experimental results show that in all signal-to-noise-ratio (SNR) regions, the proposed method achieves lower normalized mean squared error (NMSE) than the existing DNSP schemes with minimum mean square error (MMSE)-based CE. For example, when the SNR is 0 decibel (dB), the proposed scheme achieves similar NMSE as that of the MMSE-based CE scheme at 20 dB, thereby significantly improving the estimation accuracy of CE. In addition, relative to the existing schemes, the improvement of the proposed scheme presents its robustness against the impacts of parameter variations.
Influence of natural and anthropogenic controls on runoff in the Keriya River, central Tarim Basin, China
Authors: Wang Jinhua , Zhang Feng , Luo Guangming , Guo Yuchuan , Zheng Jianghua , Wu Shixin , Keram Qalibinur , Liu Suhong , Shi Qingdong
Published: May 2022

The potential impact of natural factors on the runoff of intermittent rivers and ephemeral streams (IRES) has been largely ignored in the Tarim Basin, China. A representative example is the Keriya River. To quantify the long-term dynamic variations in lower reach surface runoff of IRES, river length, defined as the distance between a selected fix point along the perennial river segment to its dynamic, ephemeral end, was used as an indicator. Using a total of 272 remote sensing images, we digitized and measured the distance (river length) between the center of Yutian County and the river’s end point on each image, and then calculated monthly inter-annual and intra-annual variations in length of the lower Keriya River from 2000 to 2019. Hydrometeorological data were combined with descriptors of anthropogenic disturbances to assess the relative influence of natural factors and anthropogenic disturbances on lower reach river runoff. The results showed that intra-annual variations in river length fluctuated seasonally, with the minimum value occurring in June; two main peaks occurred in March and August. The minimum June value in river length was closely linked to an increase in agricultural water demand and a decrease in upper reach runoff. The August peak in river length was related to the peak values in upper reach runoff and agricultural water demand; upper reach runoff made a significant contribution because the former was about 20% more than the latter in summer. The March peak corresponded to elevated lower reach groundwater levels and to the melting of ice along river channels. Inter-annual variations in river length were due to inter-annual variations in upper reach runoff and middle reach agricultural water use which increased slightly during the study period. Inter-annual variations in frequency and amplitude of the fluctuations in river length were mainly controlled by changes in upper reach runoff. The minimum in river length in 2009 was consistent with the low in upper reach runoff of the Keriya River and other rivers in the Tarim Basin. The most significant factors controlling variations in river length are natural in origin.
Performance evaluation of micro lens arrays: Improvement of light intensity and efficiency of white organic light emitting diodes
Authors: Adhikary Apurba , Bhuiya Joy , Murad Saydul Akbar , Hossain Md. Bipul , Uddin K. M. Aslam , Faysal MD Estihad , Rahaman Abidur , Bairagi Anupam Kumar
Published: May 2022

This paper proposes a unique method to improve light intensity and efficiency of white organic light emitting diodes (OLEDs) by engraving micro lens arrays (MLAs) on the outer face of the substrate layer. The addition of MLAs on the substrate layer improves the light intensity and external quantum efficiency (EQE) of the OLEDs. The basic OLED model achieved an EQE of 14.45% for the effective refractive index (ERI) of 1.86. The spherical and elliptical (planoconvex and planoconcave) MLAs were incorporated on the outer face of the substrate layer to increase the EQE of the OLEDs. The maximum EQE of 17.30% was obtained for Convex-1 (elliptical planoconvex) MLA engraved OLED where the ERI was 1.70. In addition, Convex-1 MLA engraved OLED showed an improvement of 3.8 times on the peak electroluminescence (EL) light intensity compared to basic OLED. Therefore, Convex-1 MLA incorporated OLED can be considered as a potential white OLED because of its excellent light distribution and intensity profile.