bluuebunny/crossref_metadata_2025 huggingface dataset:
Optimization and prediction of the cotton fabric dyeing process using Taguchi design-integrated machine learning approach
Authors: Pervez Md. Nahid , Yeo Wan Sieng , Lin Lina , Xiong Xiaorong , Naddeo Vincenzo , Cai Yingjie
Published: July 2023

The typical textile dyeing process calls for a wide range of operational parameters, and it has always been difficult to pinpoint which of these qualities is the most important in dyeing performance. Consequently, this research used a combined design of experiments and machine learning prediction models’ method to offer a sustainable and beneficial reactive cotton fabric dyeing process. To be more precise, we built a least square support vector regression (LSSVR) model based on Taguchi's statistical orthogonal design (L27) to predict exhaustion percentage (E%), fixation rate (F%), and total fixation efficiency (T%) and color strength (K/S) in the reactive cotton dyeing process. The model's prediction accuracy was assessed using many measures, including root mean square error (RMSE), mean absolute error (MAE), and the coefficient of determination (R2). Principal component regression (PCR), partial least square regression (PLSR), and fuzzy modelling were some of the other types of regression models used to compare results. Our findings reveal that the LSSVR model greatly outperformed competing models in predicting the E%, F%, T%, and K/S. This is shown by the LSSVR model's much smaller RMSE and MAE values. Overall, it provided the highest possible R2values, which reached 0.9819.
Microscopic-scale magnetic recording of brain neuronal electrical activity using a diamond quantum sensor
Authors: Hansen Nikolaj Winther , Webb James Luke , Troise Luca , Olsson Christoffer , Tomasevic Leo , Brinza Ovidiu , Achard Jocelyn , Staacke Robert , Kieschnick Michael , Meijer Jan , Thielscher Axel , Siebner Hartwig Roman , Berg-Sørensen Kirstine , Perrier Jean-François , Huck Alexander , Andersen Ulrik Lund
Published: July 2023

Quantum sensors using solid state qubits have demonstrated outstanding sensitivity, beyond that possible using classical devices. In particular, those based on colour centres in diamond have demonstrated high sensitivity to magnetic field through exploiting the field-dependent emission of fluorescence under coherent control using microwaves. Given the highly biocompatible nature of diamond, sensing from biological samples is a key interdisciplinary application. In particular, the microscopic-scale study of living systems can be possible through recording of temperature and biomagnetic field. In this work, we use such a quantum sensor to demonstrate such microscopic-scale recording of electrical activity from neurons in fragile living brain tissue. By recording weak magnetic field induced by ionic currents in mouse corpus callosum axons, we accurately recover signals from neuronal action potential propagation while demonstrating in situ pharmacology. Our sensor allows recording of the electrical activity in neural circuits, disruption of which can shed light on the mechanisms of disease emergence. Unlike existing techniques for recording activity, which can require potentially damaging direct interaction, our sensing is entirely passive and remote from the sample. Our results open a promising new avenue for the microscopic recording of neuronal signals, offering the eventual prospect of microscopic imaging of electrical activity in the living mammalian brain.
Exceptional population genomic homogeneity in the black brittle star Ophiocomina nigra (Ophiuroidea, Echinodermata) along the Atlantic-Mediterranean coast
Authors: Leiva Carlos , Pérez-Sorribes Laia , González-Delgado Sara , Ortiz Sandra , Wangensteen Owen S. , Pérez-Portela Rocío
Published: July 2023

The Atlantic-Mediterranean marine transition is characterised by strong oceanographic barriers and steep environmental gradients that generally result in connectivity breaks between populations from both basins and may lead to local adaptation. Here, we performed a population genomic study of the black brittle star,Ophiocomina nigra, covering most of its distribution range along the Atlantic-Mediterranean region. Interestingly,O. nigrais extremely variable in its coloration, with individuals ranging from black to yellow-orange, and different colour morphs inhabiting different depths and habitats. In this work, we used a fragment of the mitochondrialCOIgene and 2,374 genome-wide ddRADseq-derived SNPs to explore: (a) whether the different colour morphs ofO. nigrarepresent different evolutionary units; (b) the disruptive effects of major oceanographic fronts on its population structure; and (c) genomic signals of local adaptation to divergent environments. Our results revealed exceptional population homogeneity, barely affected by oceanographic fronts, with no signals of local adaptation nor genetic differentiation between colour morphs. This remarkable panmixia likely results from a long pelagic larval duration, a large effective population size and recent demographic expansions. Our study unveils an extraordinary phenotypic plasticity inO. nigra, opening further research questions on the ecological and molecular mechanisms underpinning coloration in Ophiuroidea.
The prevalence and predictors of geriatric giants in community-dwelling older adults: a cross-sectional study from the Middle East
Authors: Badrkhahan Seyedeh Zahra , Ala Moein , Fakhrzadeh Hossein , Yaghoobi Arash , Mirzamohamadi Sara , Arzaghi Seyed Masoud , Shahabi Sina , Sharifi Farshad , Ostovar Afshin , Fahimfar Noushin , Nabipour Iraj , Larijani Bagher , Shafiee Gita , Heshmat Ramin
Published: July 2023

The term “geriatric giants” refers to the chronic disabilities of senescence leading to adverse health outcomes. This study aimed to investigate the prevalence and predictors of geriatric giants in Southern Iran. The participants were selected from Bushehr city using a multistage cluster random sampling method. Demographic data were collected through interviews. Frailty, incontinence, immobility, depression, cognitive impairment, and malnutrition were measured by questionnaires and instruments. Finally, data from 2392 participants were analyzed. The prevalence of fecal incontinence was less than 1% among all participants and similar in men and women. In contrast, compared with men, women had higher prevalence of urinary incontinence (36.44% vs. 17.65%), depression (39.05% vs. 12.89%), anorexia and malnutrition (2.35% vs. 0.82%), immobility (8.00% vs. 2.5%), frailty (16.84 vs. 7.34), and pre-frailty (54.19 vs. 38.63%). The prevalence of dependence and cognitive impairment was also higher in women and considerably increased with the age of participants. In total, 12.07% of subjects were frail, and 46.76% were pre-frail. The prevalence of frailty exponentially increased in older age, ranging from 4.18% among those aged 60–64 years to 57.35% in those aged ≥ 80 years. Considering 95% confidence interval (CI), multivariate logistic regression revealed that low physical activity [odds ratio (OR) 31.73 (18.44–54.60)], cancer (OR 3.28 (1.27–8.44)), depression [OR 2.42 (1.97–2.98)], age [OR 1.11 (1.08–1.14)], waist circumference [OR 1.03 (1.01–1.06)], BMI [OR 1.07 (1.01–1.14)], MNA score [OR 0.85 (0.79–0.92)], polypharmacy [OR 2.26 (1.30–3.95)] and male gender [OR 0.63 (0.42–0.93)] were independently associated with frailty. White blood cell count (WBC), smoking, marital status, and number of comorbidities were not independently associated with frailty. Low physical activity was the strongest predictor of frailty, which may need more attention in geriatric care. Frailty, its predictors, and other components of geriatric giants were considerably more common among women and older ages.
Thermally tunable Dyakonov surface waves in semiconductor nanowire metamaterials
Authors: Moradi Mostafa
Published: July 2023

The development of engineered metamaterials has enabled the fabrication of tunable photonic devices capable of manipulating the characteristics of electromagnetic surface waves. Integration of semiconductors in metamaterials is a proven approach for creating thermally tunable metamaterials through temperature control of the semiconductor carrier density. In this paper, an interface consisting of an isotropic dielectric material as a cover and an indium antimonide (InSb) nanowire metamaterial as a substrate, is theoretically introduced to investigate the propagation conditions of Dyakonov surface waves in terahertz (THz) frequencies. Various temperature-dependent properties of Dyakonov surface waves in such a geometry is studied, including allowed THz regions, angular existence domain, dispersion relation, directionality, localization degree and figure of merit. The proposed configuration due to the presence of significant birefringence in InSb nanowire metamaterial, has potential applications in THz sensing, imaging and spectroscopy.
Allergen-induced NLRP3/caspase1/IL-18 signaling initiate eosinophilic esophagitis and respective inhibitors protect disease pathogenesis
Authors: Yadavalli Chandra Sekhar , Upparahalli Venkateshaiah Sathisha , Kumar Sandeep , Kandikattu Hemanth Kumar , Oruganti Lokanatha , Kathera Chandra Sekhar , Mishra Anil
Published: July 2023

The current report describes a stepwise mechanistic pathway of NLRP3/caspase1/IL-18-regulated immune responses operational in eosinophilic esophagitis (EoE). We show that esophageal epithelial cells and macrophage-derived NLRP3 regulated IL-18 initiate the disease and induced IL-5 facilitates eosinophil growth and survival. We also found that A. fumigatus-exposed IL-18−/− mice or IL-18-neutralized mice are protected from EoE induction. Most importantly, we present that intravascular rIL-18 delivery to ΔdblGATA mice and CD2-IL-5 mice show the development of EoE characteristics feature like degranulated and intraepithelial eosinophils, basal cell hyperplasia, remodeling and fibrosis. Similarly, we show an induced NLRP3-caspase1-regulated IL-18 pathway is also operational in human EoE. Lastly, we present the evidence that inhibitors of NLRP3 and caspase-1 (MCC950, BHB, and VX-765) protect A. fumigatus- and corn-extract-induced EoE pathogenesis. In conclusion, the current study provides a new understanding by implicating NLRP3/caspase1-regulated IL-18 pathway in EoE pathogenesis. The study has the clinical significance and novel therapeutic strategy, which depletes only IL-18-responsive pathogenic eosinophils, not naïve IL-5-generated eosinophils critical for maintaining innate immunity.
Topological magnon-photon interaction for cavity magnonics
Authors: Lee Jongjun M. , Hwang Myung-Joong , Lee Hyun-Woo
Published: July 2023

The study of cavity magnonics and topological insulators has made significant advances over the past decade, however the possibility of combining the two fields is still unexplored. Here, we explore such connection by investigating hybrid cavity systems that incorporate both a ferromagnet and a topological insulator. We find that electrons in the topological surface state efficiently mediate the effective electric dipole coupling between the spin of the ferromagnet and the electric field of the cavity, in contrast with the conventional cavity magnonics theory based on magnetic dipole coupling. We refer to this coupling as topological magnon-photon interaction, estimating it one order of magnitude stronger than the conventional magnon-photon coupling, and showing that its sign can be manipulated. We discuss the potential of our proposed device to allow for scaling down and controlling the cavity system using electronics. Our results provide solid ground for exploring the functionalities enabled by merging cavity magnonics with topological insulators.
An electrogenetic interface to program mammalian gene expression by direct current
Authors: Huang Jinbo , Xue Shuai , Buchmann Peter , Teixeira Ana Palma , Fussenegger Martin
Published: July 2023

Wearable electronic devices are playing a rapidly expanding role in the acquisition of individuals’ health data for personalized medical interventions; however, wearables cannot yet directly program gene-based therapies because of the lack of a direct electrogenetic interface. Here we provide the missing link by developing an electrogenetic interface that we call direct current (DC)-actuated regulation technology (DART), which enables electrode-mediated, time- and voltage-dependent transgene expression in human cells using DC from batteries. DART utilizes a DC supply to generate non-toxic levels of reactive oxygen species that act via a biosensor to reversibly fine-tune synthetic promoters. In a proof-of-concept study in a type 1 diabetic male mouse model, a once-daily transdermal stimulation of subcutaneously implanted microencapsulated engineered human cells by energized acupuncture needles (4.5 V DC for 10 s) stimulated insulin release and restored normoglycemia. We believe this technology will enable wearable electronic devices to directly program metabolic interventions.
A fluorescent probe based on aptamer gold nanoclusters for rapid detection of mercury ions
Authors: Wang Ying , Xu Yinyu , Jiang Ruina , Dong Quanyong , Sun Yingying , Li Wang , Xiong Ying , Chen Yanni , Yi Sili , Wen Qian
Published: July 2023

In the present study, a fluorescent probe based on aptamer gold nanoclusters (apt-AuNCs) was prepared for the ultrasensitive detection of Hg2+ in food.
Unbiased in silico design of pH-sensitive tetrapeptides
Authors: Hu Yue , Rigoldi Federica , Sun Hui , Gautieri Alfonso , Marelli Benedetto
Published: July 2023

We report and validate a new computational method to design tetrapeptides that assemble in response to pH stimuli to form beta-sheeted nanoassemblies and hydrogels.
First examples of room-temperature discotic nematic liquid crystals exhibiting ambipolar charge carrier mobilities
Authors: Gupta Monika , Krishna KM Abhinand , Sony Simran , Dhingra Shallu , Shah Asmita , Singh Dharmendra Pratap
Published: July 2023

A first report on orientationally ordered room-temperature discotic nematic phases having ambipolar charge carrier mobility (of the order of up to 10−3 cm2 V−1 s−1).
B(C6F5)3-mediated direct intramolecular C7-alkenylation of N-propargylindoles
Authors: Cui Jie , Wang Tongdao
Published: July 2023

Metal-free direct C7-alkenylation of N-propargylindoles without directing groups is described. C7-Alkenylation products could further convert into the fused indoles by deprotonation and finally polyaromatic N-heterocycles by hydride abstraction.
Switchable reactivity of 2-benzoyl glycals towards stereoselective access of 1-3 and 1-1 S/O linked disaccharides
Authors: Zargar Irshad Ahmad , Rasool Bisma , Sakander Norein , Mukherjee Debaraj
Published: July 2023

We have developed a synthesis of 1-3 and 1-1 disaccharides from 2-benzoyl glycal and anomeric thiol and/or hydroxy sugar acceptors under mild conditions at room temperature.
Phosphorus-induced activation of Ir metallene for efficient acidic overall water electrolysis
Authors: Wang Ziqiang , Li Xinmiao , Zhang Hugang , Deng Kai , Yu Hongjie , Xu You , Li Xiaonian , Wang Hongjing , Wang Liang
Published: July 2023

We synthesize P-doped Ir metallene with rich defects as a highly active bifunctional catalyst for water electrolysis in 0.5 M H2SO4, producing hydrogen at 10 mA cm−2 with a low operation voltage of 1.508 V.
Effects of intermetal distance on the electrochemistry-induced surface coverage of M–N–C dual-atom catalysts
Authors: Yang Weijie , Jia Zhenhe , Chen Liugang , Zhou Binghui , Zhang Di , Han Yulan , Gao Zhengyang , Li Hao
Published: July 2023

Intermetal distance plays a prominent role in determining the electrochemistry-induced surface coverage of dual-atom catalysts (DACs).
Molecular simulation studies on the design of multicomponent sorbic acid crystals for tuning solubility
Authors: Li Chang , Wu Di , Gao Zhenguo , Chen Wei
Published: July 2023

The solubility of multicomponents is improved compared to that of SA.
The E3 state of FeMoco: one hydride, two hydrides or dihydrogen?
Authors: Pang Yunjie , Bjornsson Ragnar
Published: July 2023

TheE3redox state of nitrogenase was systematically investigated by QM/MM calculations. The most stable structures feature an open belt-sulfide bridge and varying double-hydride coordination (or an H2ligand).
New insights into the protein stabilizing effects of trehalose by comparing with sucrose
Authors: Ahlgren Kajsa , Olsson Christoffer , Ermilova Inna , Swenson Jan
Published: July 2023

3D visualization of the water covered myoglobin surface in the trehalose system. The white stick figures are trehalose molecules located outside the protein hydration layer.
Reactions of main group compounds with azides forming organic nitrogen-containing species
Authors: Zhu Lizhao , Kinjo Rei
Published: July 2023

Main group compounds react with azides leading to diverse N-containing molecules. In this review, the reactions of main group compounds with various azides are summarized, emphatically highlighting their reaction patterns and mechanisms.
Homoleptic complexes of isocyano- and diisocyanobiazulenes with a 12-electron, ligand-based redox capacity
Authors: Connelly Patrick T. , Applegate Jason C. , Maldonado David A. , Okeowo Monisola K. , Henke Wade C. , Oliver Allen G. , Berrie Cindy L. , Barybin Mikhail V.
Published: July 2023

The redox non-innocent 2-isocyano-6,6′-biazulenic ligand platform exhibits reduction potential inversion and offers construction of molecular organometallic electron reservoirs with 2e−-per-ligand reversible redox capacity.
A process-level perspective of the impact of molecular force fields on the computational screening of MOFs for carbon capture
Authors: Cleeton Conor , de Oliveira Felipe Lopes , Neumann Rodrigo F. , Farmahini Amir H. , Luan Binquan , Steiner Mathias , Sarkisov Lev
Published: July 2023

The question we pose in this study is to what extent the ranking of metal organic frameworks (MOFs) for pressure swing adsorption-based carbon capture depends on the choice of the commonly available forcefields.
The continuous on-line leaching method coupled to inductively coupled plasma mass spectrometry for risk assessment of food safety and for sourcing of elements: a tutorial review
Authors: Kierulf Alastair , Beauchemin Diane
Published: July 2023

The continuous on-line leaching method is comparable to batch methods for assessment of food safety but allows sourcing of elements.
De novodesign of a stapled peptide targeting SARS-CoV-2 spike protein receptor-binding domain
Authors: Thakkar Ravindra , Agarwal Dilip K. , Ranaweera Chathuranga B. , Ishiguro Susumu , Conda-Sheridan Martin , Gaudreault Natasha N. , Richt Juergen A. , Tamura Masaaki , Comer Jeffrey
Published: July 2023

Binding configuration of ade novostapled peptide on SARS-CoV-2 spike protein, as predicted by molecular simulation. Stapled residues enhance peptide stability while interacting residues engage key amino acids on the protein receptor-binding domain.
The combined effect of pyrazole and amino groups: preparation of novel energetic coordination compounds with high ClO4− content
Authors: Wang Tingwei , Zhang Chao , Xu Meiqi , Kuang Baolong , Xie Zhiming , Lu Zujia , Yi Zhenxin , Li Yan , Zhang Jianguo
Published: July 2023

Cu(H2DAPZCA)2(ClO4)4 (EIsCCs-1) has a multi-functional structure composed of an ionic salt and a coordination compound. It also has the advantages of high ClO4− content and oxygen balance, acceptable mechanical stimulation and excellent explosion performance.
Surface-decorated porphyrinic zirconium-based metal–organic frameworks (MOFs) using post-synthetic self-assembly for photodegradation of methyl orange dye
Authors: Kobaisy Ahmed M. , Elkady Marwa F. , Abdel-Moneim Ahmed A. , El-Khouly Mohamed E.
Published: July 2023

We report herein the surface decoration of a water-soluble free-base porphyrin, over three different zirconium-based metal–organic frameworks of different linker structure and functionality; namely UiO66, UiO66-NH2, and MIP-202, via self-assembly.
Preparation and characterization of 3D hydroxyapatite/collagen scaffolds and its application in bone regeneration with bone morphogenetic protein-2
Authors: Xie Hongyu , Ruan Sijie , Zhao Minlong , Long Jindong , Ma Xueling , Guo Jinhong , Lin Xuandong
Published: July 2023

Desirable bone engineering materials should have a conducive three-dimensional (3D) structure and bioactive mediators for guided bone regeneration.
Uniform titania-supported Ce(iii) carbonate cluster catalysts for degradation of reactive oxygen species
Authors: Kumar Ram , Venardi V. , Helal Y. , Song Chengyu , Katz Alexander
Published: July 2023

Uniform 2.5 nm Ce(iii) carbonate clusters on TiO2 function as ROS degradation catalysts, consistent with a superoxide dismutase–catalase tandem reaction mechanism.
Cell-free layer development and spatial organization of healthy and rigid red blood cells in a microfluidic bifurcation
Authors: Rashidi Yazdan , Aouane Othmane , Darras Alexis , John Thomas , Harting Jens , Wagner Christian , Recktenwald Steffen M.
Published: July 2023

The flow and spatiotemporal organization of healthy and rigid red blood cells was investigated in a microfluidic T-junction to understand how bifurcations and branches in the microcirculation affect blood flow.
Many-body interactions between curvature-inducing membrane inclusions with arbitrary cross-sections
Authors: Galatola P. , Fournier J.-B.
Published: July 2023

We compute the multi-body interactions in tensionless membranes of curvature-inducing proteins with arbitrary cross sections and uniform detachment angles. For circular proteins forming regular polygons, we give analytical asymptotic expressions.
A metal–organic framework based propylene nano-trap with dual functionalities for highly efficient propylene/propane separation
Authors: Wen Hui-Min , Liu Miaoyu , Ling Yujia , Gu Xiao-Wen , Liu Di , Yu Chenyi , Liang Yulan , Xie Bo , Li Bin , Hu Jun
Published: July 2023

We have reported a dual functionalized single-molecule nano-trap MOF with both top-tier C3H6capture capacity and selectivity, affording both remarkably large C3H6uptake of 2.6 mmol g−1and high dynamic selectivity of 10 for C3H6/C3H8separation.
Enhanced electromechanical performance of PSZT–PMS–PFW through morphotropic phase boundary design and defect engineering
Authors: Qiao Peixin , Yang Ying , Wang Yiping , Zhang Mingzhi , Qian Pai , Wang Jiakang , Zhang Jiyang
Published: July 2023

It is desirable but challenging to explore piezoelectric ceramics with high mechanical quality factor Qm and large mechanical piezoelectric coefficient d33 simultaneously because of the intrinsic restriction between d33 and high Qm.
Bulk and film synthesis pathways to ternary magnesium tungsten nitrides
Authors: Rom Christopher L. , Smaha Rebecca W. , Knebel Callan A. , Heinselman Karen N. , Neilson James R. , Bauers Sage R. , Zakutayev Andriy
Published: July 2023

Thin film sputtering syntheses make new cation disordered Mg–W–N phases. Annealing the films drives cation ordering, which matches the phase produced by bulk synthesis.
Significantly enhanced mechanoluminescence from Nb5+ co-doped ZrO2:Sm3+via a high valence ion doping strategy
Authors: Tong Jia , Huan Jun , Yu Xin , Cheng Jia-Hui , Zhang Zhi-Jun , Xing Juan-Juan , Zhao Jing-Tai , Yang Xin-Xin
Published: July 2023

The mechanoluminescence and afterglow properties of ZrO2:Sm3+ were significantly improved by introducing Nb5+ into the phosphor. Combined with the trap state analysis, a probable luminescence mechanism model was produced.
Mitochondrial protein MPV17 promotes β-cell apoptosis in diabetogenesis
Authors: Tang Qiaoli , Shi Wanting , Liu Ming , Tang Liqin , Ren Wei , Shi Shaolin
Published: July 2023

MPV17 is a mitochondrial inner membrane protein, and its deficiency can cause mitochondrial DNA (mtDNA) depletion, increase reactive oxygen species (ROS), and promote apoptosis in several cell types, suggesting that MPV17 plays a protective role in cells although the underlying mechanism remains unknown. To test whether MPV17 is also protective in diabetic kidney disease, we treated Mpv17-deficient mice with streptozotocin (STZ) and surprisingly found that they were resistant to diabetes. Mpv17 deficiency was also found to confer resistance to the diabetes induced by an insulin mutation (Ins2Akita), which represents a mouse model of monogenic diabetes characterized by proinsulin misfolding and β-cell failure. In both STZ and Ins2Akita models, Mpv17 mutants had significantly less severe β-cell loss and apoptosis compared with the wild-type mice. We next showed that MPV17 is expressed in β-cells of mice normally, suggesting that MPV17 acts β-cells autonomously to facilitate apoptosis. Consistently, Mpv17 knockdown improved the viability and ameliorated the apoptosis of cultured MIN6 cells treated with STZ and palmitic acid (PA), respectively, accompanied by prevention of caspase 3 activation. The proapoptotic effect of MPV17 in β-cells is in contrast with its known anti-apoptotic effect in other cell types. Thus, we have identified a novel regulator of β-cell death in diabetes development.
Identifying Medications Underlying Communication Atypicalities in Psychotic and Affective Disorders: A Pharmacovigilance Study Within the FDA Adverse Event Reporting System
Authors: Fusaroli Michele , Simonsen Arndis , Borrie Stephanie A. , Low Daniel M. , Parola Alberto , Raschi Emanuel , Poluzzi Elisabetta , Fusaroli Riccardo
Published: July 2023

Purpose:

Communication atypicalities are considered promising markers of a broad range of clinical conditions. However, little is known about the mechanisms and confounders underlying them. Medications might have a crucial, relatively unknown role both as potential confounders and offering an insight on the mechanisms at work. The integration of regulatory documents with disproportionality analyses provides a more comprehensive picture to account for in future investigations of communication-related markers. The aim of this study was to identify a list of drugs potentially associated with communicative atypicalities within psychotic and affective disorders.

Method:

We developed a query using the Medical Dictionary for Regulatory Activities to search for communicative atypicalities within the FDA Adverse Event Reporting System (updated June 2021). A Bonferroni-corrected disproportionality analysis (reporting odds ratio) was separately performed on spontaneous reports involving psychotic, affective, and non-neuropsychiatric disorders, to account for the confounding role of different underlying conditions. Drug–adverse event associations not already reported in the Side Effect Resource database of labeled adverse drug reactions (unexpected) were subjected to further robustness analyses to account for expected biases.

Results:

A list of 291 expected and 91 unexpected potential confounding medications was identified, including drugs that may irritate (inhalants) or desiccate (anticholinergics) the larynx, impair speech motor control (antipsychotics), or induce nodules (acitretin) or necrosis (vascular endothelial growth factor receptor inhibitors) on vocal cords; sedatives and stimulants; neurotoxic agents (anti-infectives); and agents acting on neurotransmitter pathways (dopamine agonists).

Conclusions:

We provide a list of medications to account for in future studies of communication-related markers in affective and psychotic disorders. The current test case illustrates rigorous procedures for digital phenotyping, and the methodological tools implemented for large-scale disproportionality analyses can be considered a road map for investigations of communication-related markers in other clinical populations.

Supplemental Material:

https://doi.org/10.23641/asha.23721345
Self-Stigma of Stuttering: Implications for Communicative Participation and Mental Health
Authors: Boyle Michael P. , Cheyne Madeline R. , Rosen Amy L.
Published: July 2023

Purpose:

The purpose of this study was to determine if self-stigma–related variables predicted communicative participation and mental health in adults who stutter. A progressive model of self-stigma was theorized and tested.

Method:

Adults who stutter (
N
= 344) completed a survey that included measures of communicative participation, global mental health, and a variety of self-stigma–related variables including perceived enacted stigma, stigma awareness, anticipated stigma, felt stigma, stereotype agreement, and stigma application, in addition to demographic and speech-related variables. Hierarchical regression was performed to test whether self-stigma–related variables progressively explained significant variance in both communicative participation and global mental health.c

Results:

After controlling for demographic and speech-related variables, stigma-related variables were found to be significant predictors of both communicative participation and global mental health among adults who stutter. Most self-stigma–related variables entered later in the model predicted additional unique variance in the outcome variables than the self-stigma–related variables entered in previous steps, thus supporting the trickle-down and progressive nature of the self-stigma model theorized.

Conclusions:

Accounting for self-stigma in the assessment and treatment of individuals who stutter may identify and ultimately reduce environmental and personal barriers to communicative functioning and well-being in people who stutter. The self-stigma terminology and model described in this study will help practitioners, researchers, and the public better understand the process of self-stigma and how it may be associated with adverse outcomes experienced by people who stutter.
Counseling Confidence in Preservice and Early Career Speech-Language Pathologists
Authors: Johnson Leslie W. , Hall Kellyn D.
Published: July 2023

Purpose:

Effective counseling skills are included in standards of practice by speech-language pathology accrediting and training programs, although many speech-language pathologists (SLPs) continue to report a lack of skills in this area. The purpose of this study was to determine whether SLP graduate students and early career SLPs who have taken a dedicated counseling course report higher levels of confidence in counseling skills than those whose counseling training was infused across the curriculum. A secondary aim was to determine which specific counseling skills have the strongest relationship with completing a counseling course.

Method:

A survey, adapted from the Counselor Activity Self-Efficacy Scales for Speech-Language Pathologists, was used to gather information from SLP graduate students and early career SLPs using nonprobability sampling. Data were analyzed from 140 surveys. Research questions were answered descriptively and with independent-samples
t
tests. Correlation analysis was used to determine which counseling skills were linked with completion of a dedicated counseling course.

Results:

Participants who completed a counseling course reported significantly increased confidence across all counseling domains assessed: Helping Skills Exploration, Helping Skills Action, Helping Skills Insight, Emotional Support Skills, and Session Management. Twenty-six counseling skills were significantly correlated to completing a counseling course. Regardless of educational approach, confidence in personal adjustment counseling skills was lower than that in informational counseling skills. However, personal adjustment counseling skills confidence was significantly higher for participants who had completed a dedicated course.

Conclusions:

Overall, the findings of this study suggest that dedicating a course to the education and training of counseling skills in graduate programs may be beneficial. Implications of these findings for clinical applications and future directions in training are discussed.
Research Based on the Selection of Regenerative Agents Based on Molecular Simulation New-Old Asphalt Diffusion Behavior
Authors: Yi Qigui , Ru Nan , Gu Jianyi
Published: July 2023

In order to understand the new-old asphalt diffusion behavior, use the Materials Studio (MS) molecular dynamic simulation software to build a matrix asphalt and aging asphalt molecular model based on the average molecular model of the asphalt, and select the appropriate force field and potential energy function. As well as parameters such as boundary conditions, set up as-phalt-regenerative dot-shaped contact models and laminar contact models. From the perspective of molecular perspectives, the diffusion behavior between the old and new asphalt and the re-generative agent is analyzed. The promotion effect of the asphalt diffusion behavior, the simulation results show that the asphalt's internal diffusion process is mutual, and the promotion effect of aromatherapy regeneratives on the spread of new and old asphalt under the same conditions is better than chain regenerative agents and waste oil regeneration agents.
Variation of Soil Carbon, Nitrogen and Phosphorus and Ecological Stoichiometric Characteristics During Land Degradation in Coal Mining Subsidence Area
Authors: Guo Yangnan , Zhang Xin , Chang Jianhong , Wang Xiaolong
Published: July 2023

In order to explore the effects of land degradation on soil carbon, nitrogen and phosphorus and ecological stoichiometry in semi-arid coal mining subsidence area, the spatial pattern of soil carbon, nitrogen and phosphorus content, reserves and ecological stoichiometric ratio in the process of land degradation was studied by space-time substitution method with the soil in three stages of non-degradation, mild degradation and severe degradation as the research object. The results showed that :(1)Land degradation caused an average decrease of soil moisture content and porosity by 50.8% and 22.4%, respectively, resulting in an increase of soil pH and bulk density by 16.0% and 23.8%, respectively.(2)The soil organic carbon content and storage decreased by 55.6% and 50.7%, respectively, due to land degradation. The carbon loss in the surface soil was significant, and the nitrogen content and storage decreased by 21.8% and 13.9%, respectively. The soil nitrogen damage in the middle layer was the largest, and the phosphorus content and storage decreased by 37.9% and 31.8%, respectively.(3)Soil C/N decreased by 18.9%, C/P and N/P increased by 7.9% and 35.4%, respectively, after mild land degradation. Soil C/N and C/P decreased by 68.2% and 64.4%, respectively, while N/P increased by 16.1% after severe land degradation. (4) Soil water content and other environmental factors have different degrees of influence on soil carbon, nitrogen and phosphorus content, C/N and C/P, but no significant correlation with soil N/P. In summary, land degradation caused by multi-dynamic erosion damage in coal mining subsidence areas will significantly reduce soil environmental quality, cause soil drought, barrenness and salinization, and reduce the storage and supply capacity of ecosystem carbon, nitrogen and phosphorus.
Retracted Article: A Post-Evaluation Method for Integrated Energy Systems Based on Triangular Whitening Weight Function
Authors: Wang Yongli , Teng Yue , Zhou Hanzhi , Dou Zhenlan , Zhang Chunyan , Sun Pei
Published: July 2023

The authors have expressed the wish to retract this article on the ground that there are
some technical issues that require to be corrected.

1. The indicator does not provide a specific quantification method.

2. The indicator weight is obtained through subjective evaluation where there is a
significant deviation between the actual project verification and the current
comprehensive energy system operation results.

3. The post evaluation index values in the article are only obtained based on the average
value obtained from expert scoring, and the fitting results do not have reference
significance.

The Publisher and Editor(s) approved to the retraction.
Study on the Optimization Measures of Carbon Emissions in Chengdu’s Territorial Space under the Trend of Clean Energy and Energy Structure Adjustment
Authors: Han Xuesong , Zheng Yuan , He Yingkun , Wang Yufei , Luo Jingru
Published: July 2023

Clean energy refers to energy that has less impact on the environment and can be used sustainably. With the intensification of global climate change and environmental pollution problems, the development of clean energy has become a common concern for governments and enterprises. In this paper, the scale of carbon emission in Chengdu is measured by analyzing LEAP model, and the carbon sink capacity is measured by the change of land use structure. Based on the trends of carbon sources and sinks, we analyze the countermeasures that Chengdu needs to take to achieve the carbon peak by 2030. Finally, based on the vision of “carbon neutrality”, suggestions are made for the optimization of Chengdu’s territorial spatial planning in terms of building a green and low-carbon territorial spatial development and protection pattern, optimizing the territorial spatial layout and factor allocation, developing clean energy technologies, and increasing the proportion of clean energy use.
Study on the Roles of Water in Solid Amine-Based Direct Air Capture of CO2
Authors: Hou Chenglong , Chen Jiaying , Lai Zhenya , Zhang Kang , Lv Hongkun , Ding Liwei
Published: July 2023

Climate change triggered by the increasing amount of CO2 released into the atmosphere has become a global priority. Direct Air Capture (DAC) of CO2 has been regarded as one of the disruptive technologies to realize negative emission. Among the multiple strategies employed, adsorption on solid amines is a promising choice owing to its low energy requirements. Since the water vapor ubiquitously exists in ambient air, understanding the role it plays in DAC by the amine-functionalized solid sorbents is of vital importance. Due to the diversity in amine and support features, both promotion and deterioration of water impact on CO2 adsorption were revealed. Herein we present a multifaceted review of the trends and innovations in DAC by solid amines under humid conditions. The effect of water was discussed over four groups of materials, based on the support categories, i.e., (a) mesoporous silica, (b) mesoporous alumina, (c) mesoporous carbon and other inorganic supports, and (d) cellulose and other organic supports.
Design of Lithium Battery Monitoring System Based on GPRS Short Message Communication
Authors: Zhang Ruoyuan , Qian Feng
Published: July 2023

The lithium battery in the new energy system works in the wilderness environment, and its data remote monitoring is often realized based on wireless communication, and this transmission method needs to set up exclusive base stations, which is costly. General Packet Radio Service (GPRS) short message communication realizes data transmission through satellite without setting up base stations. Based on the above situation, a lithium battery monitoring system based on GPRS short message communication is designed, and the system consists of monitoring terminal, GPRS receiver, and remote monitoring cloud platform. For the software and hardware requirements of data acquisition, data monitoring and GPRS short message communication, the corresponding design ideas and implementation scheme are given. Meanwhile, considering the impact of wilderness environment on satellite communication, a transmission error control method based on data backup is proposed to improve its transmission reliability. Finally, through practical testing, it is verified that the system can effectively transmit monitoring data and locate lithium batteries, and maintenance personnel can monitor data in real time through the cloud platform to reduce the construction and maintenance costs of remote monitoring.
Research on Industrial Product Design under the Zero Carbon Concept
Authors: Zhou Ziru , Zhong Qinghua
Published: July 2023

In the context of modernisation, as the state advocates green consumption in various fields, the concept of green consumption continues to influence the public’s consumption philosophy and more and more consumers are gradually moving towards green consumption. The essence of the green consumption concept lies in the high regard that humans have for the natural ecological environment and the pursuit of sustainable development, while zero carbon is the embodiment of ecological and sustainable lifestyles. From a global perspective, the concept of zero carbon is becoming an indispensable tool for companies to achieve profitability, competitiveness and healthy and stable development. With this in mind, we have investigated the design of industrial products based on the zero carbon concept in the hope of contributing to the social and economic shift towards zero carbon.
Analysis of the Development Trend in Agriculture Non-point Source Pollution Based on CiteSpace
Authors: Wang Yan , Jiao Yan , Yang Wenzhu , Ling Ling
Published: July 2023

This paper uses CiteSpace to visualize and analyze the literature related to agricultural non-point source pollution in China Knowledge Network (CNKI) from 1993~2022. The results showed that the research on agricultural non-point source pollution has gone through three stages: the beginning (1993~2006), booming development (2007~2011), and stable development (2011-2022). The research on agricultural non-point source pollution focuses mainly on agricultural non-point source pollution, pollution control, and model simulation. Agricultural non-point source pollution has always played a leading role in the development of the research field since the research until now, and model simulation and spatial distribution have been continuously cited from the emergence of clustering until now, and are widely available in the research field.
Determination of Organic Carbon Content of Corn Stalk: A Casestudy in Laiyuan County, Hebei Province
Authors: Liu Zhuohan , Shen Shigang , Dong Jiangxue , Yao Na , Wu Qianwen , Fu Zhaowei
Published: July 2023

Organic carbon is an important component of straw, which plays an important role in the hydrothermal conditions, physical and chemical properties of straw. In order to discuss the transformation of corn straw in straw and the influence on straw fertility, this paper selects 6 villages in Laiyuan County, Hebei Province as the study area, and uses straw organic carbon analyzer to determine the organic carbon content of straw samples before and after corn straw treatment in the study area. The results show that: The organic carbon content of corn straw in Laiyuan County is 50.62%~55.01%, with an average of 53.46%. In Laiyuan County, the organic carbon content is high in the northern townships, low in the western townships and low in the southern townships. From the spatial distribution of organic carbon content of straw, the organic carbon content of corn straw in the northern area of Laiyuan County is high, while the organic carbon content in the western area is low. The conversion of corn straw in straw and its effect on straw fertility are related to the type of straw, the amount of straw and the planting method.
Key issues of Development and Utilization of New Energy in China under Carbon Peaking and Carbon Neutrality
Authors: Yuan Bo , Zhang Jinfang , Lv Mengxuan , Gong Yichun , Xia Peng , Wu Cong
Published: July 2023

High-quality development of new energy cannot be achieved without high-level utilization. Utilization rate has become a barometer to measure the effectiveness of new energy management. Through the joint efforts of government departments, power generation enterprises, power grid enterprises, and industry insiders and outsiders, new energy utilization rate has remained above 95% for many years, achieving high-level utilization during large-scale development. In the future, with the continuous increase in the penetration rate of new energy, maintaining high utilization rates presents significant challenges in terms of technology and cost. This paper utilizes the NEOS software independently developed by the State Grid Energy Research Institute to analyse the utilization of new energy in the future and proposes relevant policy recommendations for reasonable utilization rates.
Temperature Inaccuracies During Cardiopulmonary Bypass
Authors: Salah Mohammad , Sutton Robin , Tsarovsky Gary , Djuric Michael
Published: July 2023

Cerebral hyperthermia caused by perfusate temperature greater than 37°C during the rewarming phase of CPB has been linked to postoperative neurologic deficits. The purpose of this study was to determine the accuracy of the coupled temperature measurement system and the CDI 500 arterial temperature sensor. Seventeen patients undergoing CPB were divided into four groups, each with a different temperature probe coupled to the oxygenator. The coupled temperature measurement system and CDI temperature sensors were compared with an indwelling probe placed in direct contact with the arterial perfusate. Blood, bladder, room and water temperatures, arterial line pressure, blood flow, and hemoglobin were recorded while the patients were supported with CPB. The actual blood temperature was significantly higher than the coupled temperature measurement system for two of the four groups (mean = 1.61°C and 0.91°C,p< 0.0001). A significant positive correlation between the actual temperature and the coupled temperature measurement system error was observed for the same two groups (r = 0.44,p< 0.0001). The actual temperature was significantly higher than the CDI temperature in all patients (mean = 1.2°C,p< 0.0001). The coupling mechanism on the oxygenator generates inconsistent temperature readings. The perfusionist should consider these inconsistencies when using coupled temperature measurements and may consider the use of a direct temperature measurement system. The CDI temperature error is probably the result of inadequate flow through the sensor. On the test circuit, the flow of 170 mL/min was inadequate for circuit temperature accuracy. The accuracy of the CDI temperature drastically improved when the flow-through the sensor was increased to approximately 400 mL/min. Thus, the perfusionist must ensure adequate flow through the sensor in order for the temperature mechanism to function properly. Finally, the perfusionist can prevent cerebral hyperthermia by not allowing water temperature to exceed 37°C, when using a coupled temperature measurement system.
Thrombelastograph (TEG®) Analysis of Platelet Gel Formed With Different Thrombin Concentrations
Authors: Ellis William Cory , Cassidy Linsay K. , Finney Angela S. , Spiwak Allison J. , Riley Jeffrey B.
Published: July 2023

Autologous blood transfusion is the safest and most successful way to decrease transfusion-related risks such as post-operative infections, allo-immunization, and short- and long-term immunosuppression. In addition, these fibrin sealants are known to provide coagulation support at the surgical site and act as an adjunct to the control of postoperative bleeding. The physical formation of autologous platelet fibrin gel clot is dependent on both the common pathway of the coagulation cascade and platelet activation. Platelet gel can help provide control of intraoperative and postoperative bleeding. The Thrombelastograph Hemostasis Analyzer (TEG®) measures the viscoelastic properties of a clot as it forms. Based on the information that the TEG provides, it promises to be a good choice for point of care measurement of the integrity of thrombus formed by platelet gels. Bovine blood from a single donor was sequestered into platelet-rich plasma and was made into platelet gel using calcium and three different concentrations of thrombin. The platelet gel samples were then analyzed with the TEG analyzer. The results for MA, tMA, CI, and angle were recorded and statistical analysis was performed to accept or reject the null hypothesis, which is: There is no difference between TEG parameters when analyzing platelet gels formed with calcium chloride, platelet-rich plasma and three different concentrations of thrombin A one-way analysis of variance test was performed between thrombin concentrations for MA (p= 0.19), tMA (p= 0.443), CI (p= 0.257), and angle (p= 0.323). The results showed that thrombin concentration did not affect the MA, tMA, CI, or angle as measured by the TEG analyzer. The null hypothesis was accepted. Based on a one-way analysis of variance test for MA, tMA, CI, and angle there was no significant statistical difference for the TEG samples in this experiment as reported with a 95% confidence interval.