Abstract P6-12-08: Attitudes of breast cancer associated doctors toward procreation in young patients with early breast cancer
Authors: Zhang Yuzhu , Dian Liping , Chen Qianjun , Xu Rui 
Published: March 2020

IMPORTANCE While as more young patients with breast cancer undergoing treatment and obtaining a good prognosis, the issue of breast cancer postoperative procreation has attracted more and more attention as well as the full implementation of the two-child policy in China.Little is known about current doctors attitudes toward breast cancer postoperative procreation. OBJECTIVES To examine the treatment strategies and attitude of breast cancer associated doctors for procreation after breast cancer surgery designed according to 2017 rehabilitation therapy consensus of breast cancer in China, and identify doctors’ characteristics associated with attitude scale score. DESIGN,SETTING,AND PARTICIPANTS A prospective, cross-sectional study survey was sent to breast cancer associated doctors. This survey was conducted from March 1,2019,to May 31,2019. MAIN OUTCOMES AND MEASURES Doctors were scored and categorized as having low, selective or high propensity.We assessed whether the propensity about doctors’ attitudes toward procreation for young patients with early breast cancer were associated with doctors’ specific demographic characteristics, such as gender, years of clinical practice, from developed or underdeveloped area. RESULTS Of the initial 2000 breast cancer associated doctors invited, 1247 doctors responded(62.4% of those invited)and 711(57.0% of those responded) were eligible. 383 female doctors accounted for 53.9%. The proportion of doctors with less than 5 years of practice was the largest with 335(47.1%). There were 256(36.0%) doctors from developed area and 455 from underdeveloped area. The attitudes of propensity are listed as below table.

CONCLUSIONS AND RELEVANCE Our findings have important implications for clinical practice.This study shows substantial variation in doctors’ attitude of different procreation questions, which is associated with doctors’ gender, years of clinical practice. But there is no difference in attitude propensity between developed and underdeveloped area.In a proper particular point time patients may attempt pregnancy and lactation, requiring more and larger real-world studies to confirm.

Funding: Guangdong Natural Science Foundation No. 2017A030313719;Foundation Project of Guangzhou University of Traditional Chinese Medicine, No. XKP2019002.

Attitude propensityLow propensity,No(%)Selective propensity,No(%)High propensity,No(%)Attitudes about pregnancy effects on breast cancer patients.60(8.5)323(45.4)328(46.1)Attitudes about breast cancer patient's pregnancy's effects on the fetus. 182(25.6)336(47.3)193(27.1)Attitudes about effects on doctors' decisions because it is a BRCA1-related patient. 140(19.7)317(44.6)254(35.7)Attitudes about whether a patient with breast cancer may be pregnant. 48(6.8)281(39.5)382(53.7)Attitudes about whether patients may breast-feed after delivery. 155(21.8)288(40.5)268(37.7)Attitudes about patients with breast cancer in situ getting pregnant after the surgery and radiotherapy. 494(69.5)176(24.7)41(5.8)Attitudes about getting pregnant 2 years after surgery in invasive breast cancer patients with lymph nodes-negative. 171(24.1)360(50.6)180(25.3)Attitudes about getting pregnant 5 years after surgery in invasive breast cancer patients with lymph nodes-positive.113(15.9)369(51.9)229(32.2)Attitudes about whether the patients who need endocrinotherapy still need to continue endocrine treatment after lactation.36(5.1)224(31.5)451(63.4)Attitudes about the using of hormone drugs to promote ovulation for patients with breast cancer. 272(38.3)345(48.5)94(13.2)Attitudes about agreement for a MDT consultation to make a full decision on the patients’ procreation.22(3.1)209(29.4)480(67.5)

Citation Format: Yuzhu Zhang, Liping Dian, Qianjun Chen, Rui Xu. Attitudes of breast cancer associated doctors toward procreation in young patients with early breast cancer [abstract]. In: Proceedings of the 2019 San Antonio Breast Cancer Symposium; 2019 Dec 10-14; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2020;80(4 Suppl):Abstract nr P6-12-08.