bluuebunny/crossref_metadata_2025 huggingface dataset:
Virtual reconstruction of destroyed fortifications: the case study of Santa Caterina in Verona
Authors: Russo Michele , Flenghi Giulia , Buonacucina Alessio , Russo Valentina
Published: April 2024

Military fortifications have always played a key role in territorial defense. Their location and visibility often depended on strategic military choices, such as shape. The geometric development of the latter is the result of centuries of refinement of construction techniques concerning the evolution of warfare, the architectural consistency of the fortified area, and adaptation to the orography of the territory. A final common aspect is their history, often marked by transformations that have determined the architecture's level of preservation and use. These architectures can be perfectly preserved, destroyed, or fallen into disuse. Of the latter, many examples are scattered throughout the territories, a fascinating constellation of vestiges that have lost their visibility and importance. The instruments of surveying, drawing, and representation can support the virtual rediscovery of the ancient role of architecture. This research project focuses on the Fort of Santa Caterina in Verona. Originally called Werk Hess, it is a fortification located south of Verona and built between 1848 and 1856. Only a few small traces remain today, but the Fort of Santa Caterina was an architecture of remarkable beauty because of its naturalistic and environmental inclusion, an architectural and perspective cornerstone of the fortified city due to its dominant position. Through a comprehensive course of source analysis, the survey of the existing territory, and representation in plan and space, the research project aims to give a virtual shape to this military marvel, laying the groundwork for more complex multi-disciplinary analyses of the artifact and the surrounding area.
In search of a possible dialogue between restoration and ruins. From ekphrasis to the ‘new whole’ evoked by the architectural fragment
Authors: Montanari Valeria
Published: April 2024

The ruins, the buildings in the state of ruins, the architectural fragments that characterize a landscape are increasingly involved in planning interventions; however, these interventions often go beyond the narrow field of conservation, which has as its aim the transmission to the future of the values still existent from pre-existence, but also from that of restoration in its present meaning, to encroach on real compositional exercises where the new architecture does not enter into any relationship with the ancient. It is possible, however, to glimpse in contemporary work also a conscious attention to the aesthetic and historical values transmitted by the buildings to the state of ruins that in their transformation have found a new balance.The relationship that is established over time with the environmental context makes the ruin ‘second work of art’ characterized by a new spatiality. This new spatiality will have to be considered both if there are still residual formal traces able to tell the historical past of the pre-existence (and also any relationship with other architectural emergencies, such as in the case of a fortified system to defend and control a given territory), both when the pre-existence in its fragmentary state has become a ‘new whole’.
Clinical Pharmacology in Athletic Training
Authors: Cleary Michelle A. , Abdenour Thomas E. , Pavlovich Michael
Published: April 2024

Athletic trainers have a responsibility to provide high-quality pharmaceutical care while meeting both legal and ethical requirements. Clinical Pharmacology in Athletic Training empowers athletic trainers with a functional understanding of pharmacology that enables them to formulate a treatment plan intended to mitigate disease and improve the overall health of their patients. This text incorporates the most up-to-date content from the 2020 Commission on Accreditation of Athletic Training Education (CAATE) standards, and it emphasizes interprofessional practice to enable future and current athletic trainers to collaborate with other health professionals in a manner that optimizes the quality of care.

Clinical Pharmacology in Athletic Training begins by addressing drug legislation and the legal aspects of the athletic trainer's role in sport medication. The text provides an overview of pharmacokinetics and pharmacodynamics with an emphasis on concepts relevant to clinical practice. Students are introduced to the generic and brand names, general classifications, and appropriate administration of drugs and are guided toward appropriate online reference materials. Part II of this text describes common medications for pain, inflammation, and infections. Part III includes medications for specific conditions, including respiratory, cardiovascular, gastrointestinal, neurological, gynecological, and mental health conditions. The text also includes current information on opioid analgesics, cannabis, and cannabinoid-based medications.

Clinical Pharmacology in Athletic Training teaches students to administer appropriate pharmacological agents for the management of the patient's condition. The information includes indications, contraindications, dosing, interactions, and adverse reactions. The following features are included to aid in the learning process:
Chapter objectives set the stage for the main topics covered in the chapter.Key terms are boldfaced to indicate terms of special importance, and a glossary of definitions is included at the back of the book.Red Flag sidebars highlight warnings and precautions for certain medications or medicolegal issues.Evidence in Pharmacology sidebars highlight recent research regarding medications.Clinical Application sidebars present real-life stories from the field of athletic training.Case studies highlight specific therapeutic medication applications and are accompanied by questions that prompt readers to think critically about the issues presented.Quick reference drug tables describe medication types, generic and brand names, pronunciations, common indications, and other special considerations for the athletic trainer.

Over the past decade, there has been an increased emphasis on pharmacology in athletic training. Clinical Pharmacology in Athletic Training will equip students with appropriate skills and competencies, prepare them to meet patient needs, and enable them to work in interprofessional teams.
Patient Benefactor Linker
Authors: Zahid Hira Zahid , Abid Syed Sidra , Jerome Marissa , Batool Rida , Shams Sarmad
Published: April 2024

This paper discusses a new evolution in the healthcare sector through a device by investigatingthe principle application of Artificial Neural Networks (ANN) for the selection of an optimalbenefactor-donor match in organ transplantation. The device aims to correlate ABO blood type,age and bone density of healthy subjects. Firstly, linker phase integrates a light intensity(lux)meter and an RGB Color Sensor module to perform an experimental observation of agglutinationof RBC's which is measured through a halogen illumination source that measures the lightintensity which is displayed on a screen through the microprocessor interface. Secondly, weaim to study the possibility of calcium quantification via near-infrared spectroscopy to estimatebone density which involves the use of an emitting source and a photodiode as a detector/receiver. At last the device involves designing an Artificial Neural Network (ANN) model throughthe Neural Network Toolbox of MATLAB software to get the optimal network architecturesuitable for the analysis. This architecture is achieved by simulating different Artificial NeuralNetwork (ANN) configurations. We used a non-linear ANN which can predict benefactor andpatient organ matches, while measuring ABO blood typing and calcium density of the donorsin real time and for recognizing mapping functions for which there is no requirement for aparticular basis of functions. A database was created through an intensive survey of benefactorprofiles. The results generated by ANN are promising for identifying optimal benefactor andpatient matches. This approach has potential benefits as an increase in the number of input andparameters will provide better matches and risk associated with human error are reduced. Thenetwork can further be modelled to predict survival rates.
Jean-Pierre Bat, Nicolas Courtin et Vincent Hiribarren (dir.) (2021) - Histoire du renseignement en situation coloniale
Authors: Blanchard Emmanuel
Published: April 2024

Recensé : Jean-Pierre Bat, Nicolas Courtin et Vincent Hiribarren (dir.), Histoire du renseignement en situation coloniale, Rennes, PUR, 2021, 288 p.
Robyn d’Avignon (2022) - A Ritual Geology: Gold and Subterranean Knowledge in Savanna West Africa
Authors: Hiribarren Vincent
Published: April 2024

Recensé : Robyn d’Avignon, A Ritual Geology: Gold and Subterranean Knowledge in Savanna West Africa, Durham, Duke University Press, 2022, 304 p.
Annette Joseph-Gabriel (2023) - Imaginer la libération : Des femmes noires face à l’Empire
Authors: Blum Françoise
Published: April 2024

Recensé : Annette Joseph-Gabriel, Imaginer la libération. Des femmes noires face à l’Empire (traduit de l’anglais par Jean-Baptiste Naudy), Paris, Rot-Bo-Krik, 2023, 416 p.
Current approach to venous catheterization in hemodialysis patients and important points
Authors: Kabalcı Mehmet , Çifci Aydın
Published: April 2024

Hemodialysis (HD) procedure is commonly performed in hospitals. It is typically conducted due to renal dysfunction, elevated levels of urea and serum creatinine, or excessive volume overload. Additionally, emergency hemodialysis may be implemented in cases of certain poisonings. Emergency HD procedures are usually performed through a temporary venous catheter. The majority of patients undergoing continuous HD therapy access dialysis through arteriovenous fistula and permanent HD catheter. This procedure can be carried out with a very low risk of complications when performed by experienced individuals.
Lower and Middle Paleolithic Sites and Artifacts in the Swiss Canton of Basel-Stadt
Authors: Braun Ingmar M.
Published: April 2024

The canton of Basel-Stadt, situated in the northwestern part of Switzerland, is divided into three communities: the city of Basel and the two rural communities of Riehen and Bettingen. Basel-Stadt is surrounded by France and Germany and the canton of Baselland. Although glaciers did not cover this area during the penultimate and last glacial periods, only a few finds and sites from the Lower and Middle Paleolithic have been recorded here. The sites, distributed in all three communities of Basel, Riehen and Bettingen, are found at elevated locations some distance away from the present bed of the Rhine River. Though small in number, the finds from these sites reveal that perhaps Homo erectus and certainly Neanderthals were present in the area of Basel-Stadt. The recovered material represents mostly isolated finds which are often impossible to date directly. We can only estimate their age with the aid of typology and by comparing them with artifacts from stratified contexts. In other cases, the few arti-facts present are associated with fauna remains. The work below describes the small number of little-known but in some cases important Lower and Middle Paleolithic finds from the canton of Basel-Stadt. Some are published here for the first time for an international scientific audience.
New Data on the Middle Paleolithic in Lorraine, France
Authors: Asselin Guillaume , Detrey Jean , Diemer Simon , Béguinot Serge , Griette Marc , Schmit Sébastien
Published: April 2024

The study of three open-air assemblages with bifacial tools and Levallois debitage from Lorraine (France) has allowed us to identify the first Keilmesser artifacts recorded in the Grand-Est region. These assemblages present varied knapping methods and a relatively homogeneous typology, along with the exploitation of very different raw materials. The first assemblage was collected in the area of Metz, on alluvial terraces overlooking the Moselle at “Bois Jacquemignon” in Norroy-le-Veneur. Consisting of more than 700 artifacts, this find assemblage was essentially produced from quartzite pebbles which outcrop locally. Two methods of knapping, recurrent centripetal and SSDA, coexist here for the production of flakes. Linéal Levallois debitage is less common. A bifacial reduction sequence is observed to a lesser extent on the local Bajocian chert, with scrapers and notched tools being the dominant tool types among the finds. The second assemblage, consisting of 152 artifacts, originates from the site of “Rehbrunnenwald” in Erching, located on a hill in the Bitche Region. Here the dominant raw material is Muschelkalk oolitic flint which outcrops near the site. Two knapping methods have been identified, the linéal Levallois and the recurrent-centripetal techniques. The most common tools include scrapers, foliate pieces and bifaces.
COMPOSITIONAL AND PLANNING COMPONENT OF THE UNIQUENESS OF THE ARCHITECTURAL SPACE OF THE ENVIRONMENT
Authors:   Astana International University, Kisselyova Т. , Shlyakhtich Y. ,   Kazakh Agrotechnical University named after S. Seifullin, Baidrakhmanova M.G. ,   Toraighyrov University
Published: April 2024

The study of public spaces through their analysis is key to the recon-struction of historical cities and districts, their adaptation to modern needs, and the resolution of design conflicts. The purpose of the analysis of public spaces should be to determine their "uniqueness" and the potential to improve this quality. The theoretical concepts put forward are confirmed by examples of the organization of public spaces in Astana, methods of analysis of archival materials and studies of modern urban devel-opment. Five factors of the "uniqueness" of public space are established. Based on the analysis of all existing theories, a generalizing idea of the principles of the development of the uniqueness factors of a particular public space is given. Analysis has shown that when planning and implementing the framework of the city, it is important to preserve or qualitatively introduce unique public spaces into its structure. The example of Asta-na has shown that when the status and population of any city changes, a number of dif-ficulties arise that affect the functional and planning framework of the city and the quality of perception of public spaces. Thus, the discrepancy between the large-scale system and the violation of stylistic unity is more often revealed, which destroys the ex-isting identity of the urban environment. A clear understanding of the essence of the problem will help to form the concept of an integrated approach in the design of public spaces and will pave the way for new searches in the architecture of the objects under study.
METHODS OF INJECTION STRENGTHENING OF FOUNDATIONS IN CONSTRUCTION
Authors:   International Educational Corporation, Aubakirova B.M.
Published: April 2024

The article discusses the problems of strengthening strip foundations of buildings and structures. In accordance with the main reasons for strengthening foundations and artificially improving the construction properties of the soil foundation, the reserves and reserves of the bearing capacity of the soil foundation were assessed by analyzing the results of the technical condition of the building and analyzing its physical condition and mechanical characteristics. The exact dimensions of the foundation structures, their condition and the loads acting on them were determined, and the geological and hydrogeological conditions of the surrounding area were studied. A classification of methods for strengthening foundations and artificially improving the construction properties of the soil foundation is given; it is proven that strengthening methods depend on the design features of the building, types of foundations, operating loads, engineering-geological and hydrogeological conditions. In addition to the need to strengthen, as well as the capabilities and technical equipment of organizations performing this type of work, there are many other methods. Pile reinforcement methods are one of the most effective types of foundations. Research has proven that piles are not used to strengthen foundations, since the resulting dynamic impacts can lead to additional settlement of the building being restored. The study noted the basic requirements for reliable strengthening of the foundation and artificial improvement of the construction properties of the soil foundation, especially when water-saturated salty clay soils are formed at the base of the building.
MONITORING HAZARDOUS GEOLOGICAL PROCESSES AT THE KASKELEN-TALGAR PLANT USING WITH GEODESIC METHODS
Authors:   Al-Farabi Kazakh National University, Zhiyembayeva Zh.A. , Zhanakova R.K. ,   Kazakh Automobile and Road Institute named after L.B. Goncharov, Sarybayev M.A. ,   Al-Farabi Kazakh National University, Nurtay G. ,   Al-Farabi Kazakh National University, Yelzhanov Y.E. ,   International Educational Corporation
Published: April 2024

The article discusses spectrometric, comparative-morphological and landscape-indication methods of interpretation, as well as instrumental measurements with the help of which one can study hazardous geological processes. The relevance of the study is characterized by the area's susceptibility to landslides, weathering, avalanches and other processes, and the excessive density of inhabitants in the mountainous and foothill parts of the Trans-Ili Alatau, which today is home to more than 2 million people. As a result of interpretation, several maps were created that make it possible to distribute the territory of the landfill according to the degree of danger of landslides and predict the position of individual landslide-prone areas. Using instrumental measurements, displacement values on landslide slopes were determined. Instrumental observations were carried out with a high-precision tacheometer TS15, light rangefinders, and a measuring tape using benchmarks installed on landslide-prone slopes. The purpose of the research work is to conduct research work on the study of geological changes at 27 observation posts, in order to assess the impact of the hazardous geological processes on the life of the population, buildings and communications. By analyzing the results of the conducted research, we can say that it was possible to directly decipher many unstudied, hard-to-reach landslide-prone areas.
DESIGN METHODS AND FEATURES OF FOUNDATIONS OF HIGH-RISE BUILDINGS
Authors:   International Educational Corporation, Kuanyshbai A.M. , Aubakirova B.M. ,   International Educational Corporation
Published: April 2024

The article large loads applied to the foundations of high-rise buildings from above-ground structures, as well as their high sensitivity to swaying, create their own peculiarities in the calculation and design of the foundations of high-rise buildings, which have not yet been sufficiently studied and require further research. In this regard, the study of these issues is relevant and has practical significance. The article proves that the pressure on the foundation of high-rise buildings is significantly higher than that of buildings up to 75 m high, which requires special laboratory and field studies; the features of geotechnical research, current standards, and excessive loads (1–2 MPa) are considered. High sensitivity to foundation deflections is ensured by increasing the dimensions (depth and width) of the compressed structure. The study examined the problems of calculation and design of foundations of high-rise buildings. The identified features of high-rise buildings require the development of geotechnical research, basic principles of calculation and design. It has been proven that in order to assess the accuracy of determining individual soil parameters, soil samples should be placed in devices that allow sealing the soil sample, as well as measuring pore and total pressure in order to restore the original state of the soil.
Intelligent Model for the Early Detection of Breast Cancer Using Fine Needle Aspiration of Breast Mass.
Authors: James Gabriel , Ekong Anietie , Odikwa Henry
Published: April 2024

Breast cancer is a type of cancer that forms in the cells of the breasts. It can occur in both men and women, but it is far more common in women with an increase likelihood of development caused by some risk factors like age, family history, gene mutations, hormonal factors, and exposure to estrogen. There are several essential methods for early diagnostic and detection, like regular breast self-examinations, clinical breast examination mammograms, etc. Breast cancer detection faces several challenges that span various stages from screening to diagnosis. It is in the light of these, that the drive to overcome these challenges faced by patients and medical experts to get timely diagnosis or detection of breast cancer that motivated this research. The work aims at developing an intelligent-based system for the early detection of breast cancer driven by machine learning algorithm using features obtained from a digitized image of the Fine Needle Aspiration (FNA) of breast mass. The Machine learning algorithm used was the Support Vector Machine (SVM) and was apply to the Breast Cancer dataset. Additionally, feature selection and a neural network model was applied to improve the performance of the system. This work demonstrates that SVM algorithm can be used to enhance the early detection of breast cancer. Compared with the 92% accuracy of mammography, this machine learning model achieved a higher accuracy of around 98.18% for breast cancer detection and diagnosis based on the dataset that was used.
Adatok az esélyegyenlőség szolgálatában
Authors: Földvári Mónika , Gárdos Éva Beáta
Published: April 2024

A fogyatékosság, illetve egészségi okból fakadó korlátozottság szemléletében a kétezres évek elején meghatározóvá vált paradigmaváltás során a biológiai/medikális modellről a hangsúly fokozatosan eltolódott az ún. szociális modell felé. A fogyatékosságot egyre kevésbé értékelik csupán egészségi problémaként, hanem egy tágabb keretben, a környezet szerepét is számításba véve vizsgálják, hogy egy adott egészségi probléma mennyiben korlátozza a társadalomban való részvételt. Az új definíciókhoz és módszertanhoz vezető szemléletváltás lehetővé teszi, hogy jobban megértsük, milyen tényezők befolyásolják a fogyatékos/korlátozott gyermekek kapcsolatokban, szokásos tevékenységekben és oktatásban történő részvételének lehetőségeit, és erre építve hatékonyabban előmozdítható legyen az érintett gyermekek jövőbeli boldogulása. A gyermekek fogyatékosságának/korlátozottságának felmérése több szempontból is speciális. Bár nemzetközi szinten is számos erőfeszítés történt arra vonatkozóan, hogy ezen a területen standard mérőeszközök és összehasonlítható adatok álljanak rendelkezésre, még mindig jelentős vakfoltok jellemzik az elérhető információkat. Tanulmányunkban felvázoljuk a gyermekek fogyatékosságának/korlátozottságának felmérését érintő főbb nemzetközi és hazai tendenciákat; a kihívásokat, törekvéseket és az eddig elért eredményeket.
A APLICAÇÃO DO PRINCÍPIO DA INSIGNIFICÂNCIA NO DIREITO PENAL MILITAR
Authors: Araújo Cláudio Henrique Santos , Feller Thiago de Almeida
Published: April 2024

Este estudo tem como propósito analisar a implementação do princípio da bagatela no cenário penal militar. Grande parte dos especialistas entende o princípio da insignificância como uma causa que transcende a legislação, indicando que comportamentos que resultam em danos mínimos ao bem jurídico podem ser considerados não tipificados como, por exemplo, um atraso leve ou furto de pequeno valor. No entanto, é importante salientar que este é um princípio não codificado e sua aplicação gera divergências, inclusive no que concerne à possibilidade de sua utilização no âmbito militar. Pode-se concluir que, embora seja um princípio considerado relevante no campo do direito penal, não encontra aceitação no contexto da justiça militar. A metodologia adotada foi a dedutiva hipotética, na qual o tema foi abordado de forma ampla, por meio de pesquisa bibliográfica.
Urban morphology modulates thunderstorm process and associatied cloud-to-ground lightning activity over Beijing metropolitan region
Authors: Shi Tao , Yang Yuanjian , Lu Gaopeng , Zheng Zuofang , Zi Yucheng , Tian Ye , Liu Lei , Lolli Simone
Published: April 2024

Abstract. The effect of urban barriers may have a significant impact on the patterns of thunderstorm processes and lightning activity, but there is still a lack of comprehensive mechanical explanations. The observational analysis carried out in this study found that cloud-to-ground (CG) lighting activity tends to cluster around the outer boundaries of the mega cities, while, on the opposite, CG gathers within the small-sized city. When a squall line originating from a type of mesoscale convective system (MCS) known as '0713' passed through the built-up area, the barrier effect of the rough underlying surface contributed to the separation of the cold pool. This led to weakening of vertical airflow and breaking of the convergence line, ultimately triggering the bifurcation of the thunderstorm. Simulation results complement these observations. When buildings outside the 5 Ring Road (RR) are replaced with bare soil, the separation of the cold pool is minimized. Furthermore, the density of the buildings also influenced the strength of the barrier effect. Therefore, the specific urban morphologies were identified as a critical factor in modulating cloud-to-ground (CG) lightning activity and the organization process of thunderstorms. This study offers a fundamental foundation and technical support for predicting and assessing urban cloud-to-ground (CG) lightning risks. It holds significant implications for understanding excess urban warming, its prediction and assessment, and the resulting thermal risk, influenced by factors such as ventilation, sea breezes, and the geophysical environment in coastal cities.
Complexity of nutrient enrichment on subarctic peatland soil CO2 and CH4 production under increasing wildfire and permafrost thaw
Authors: Byun Eunji , Rezanezhad Fereidoun , Slowinski Stephanie , Lam Christina , Saraswati Saraswati , Wright Stephanie , Quinton William L. , Webster Kara L. , Van Cappellen Philippe
Published: April 2024

Abstract. The adverse impacts of excessive soil nutrients on water quality and carbon sequestration have been recognized in tropical and temperate regions, with already widespread industrial farming and urbanization, but rarely in subarctic regions. However, recent studies have shown significant increases in porewater nitrogen (N) and phosphorus (P) concentrations in burned subarctic peatlands and downstream waters, which is a growing concern as climate change leads to increasing wildfires, permafrost thaws, and waterlogged peatlands. In this study, we present the results of a short-term incubation experiment conducted on soils from subarctic bogs and fens, aimed at evaluating the effects of high levels of nutrients on carbon gas production rates. We divided aliquots of the peatland soil samples into separate containers and added artificial porewater to each, enriching them with dissolved inorganic nitrogen (N), phosphorus (P), both, or none for controls. Overall, the fen samples showed higher carbon dioxide (CO2) and methane (CH4) production rates at 1, 5, 15, and 25 °C compared to the bog samples, which we attributed to differences in soil properties and initial microbial biomass. The bog sample with added N produced more CO2 compared to its control, while the fen sample with added P produced more CO2 compared to its control. It was unexpected that the addition of both N and P reduced CO2 but increased CH4 production in both soils compared to their controls. After a month, the pore water C, N, and P stochiometric ratios approached the initial soil microbial biomass ratios, suggesting microbial nutrient recycling in an inherently nutrient-poor soil environment. These preliminary results imply a complex response of carbon turnover in peatland soils to nutrient enrichment.
El lenguaje en las nuevas tecnologías
Authors: Sabogal Cárdenas Cleóbulo
Published: April 2024

“El lenguaje es el vestido del pensamiento”, sostuvo el poeta, ensayista y lexicógrafo inglés Samuel Johnson. Con esta máxima, el autor del Diccionario de la lengua inglesa ratificó la estrecha relación que siempre ha existido entre lenguaje y pensamiento. De ahí que el filósofo y escritor español Miguel de Unamuno haya afirmado que “la lengua no es la envoltura del pensamiento, sino el pensamiento mismo”.
Revisitando conceitos e dados sobre violência sexual contra crianças e adolescentes: o Amazonas em debate
Authors: Oliveira Márcio de , Cavalcanti Francisca Maria Coelho , Nascimento Jefferson Araújo do
Published: April 2024

O objetivo deste artigo é revisitar o conceito sobre violência sexual contra crianças e adolescentes e suas tipificações para melhor apropriação do seu real significado, além de expor as denúncias notificadas e a rede de proteção no estado do Amazonas, em especial na Região Metropolitana de Manaus, mas não apenas. Tem-se como embasamento metodológico a pesquisa bibliográfica e documental, bem como se apropriou da análise qualitativa fazendo uma ponte com os Estudos Culturais de Stuart Hall e da Teoria Política de Hannah Arendt. O estudo revela que essa violência que aniquila milhares de vidas em desenvolvimento deve ser combatida ferozmente como a força da natureza que se encontra neste imenso território que se chama Amazonas. Para isso, chama-se atenção do Estado e de seus órgãos de proteção enquanto poder e de uma sociedade civil que precisa ter conhecimento da extensão do que representa violência sexual contra crianças e adolescentes.
A Comprehensive Case Report on Embryonal Rhabdomyosarcoma
Authors: Babu Dhanya , Priya A , Chander Yadav K. Arun
Published: April 2024

Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in the pediatric and adolescent population. While they can develop anywhere in the body, the genitourinary tract is the second most common primary location for an RMS to develop. Here we report a case of 2 year old male patient who have presented with the complaints of perianal rash and difficulty in voiding for 2 weeks. According to the histopathological and immunohistochemical report, it was diagnosed as an embryonic variety of rhabdomyosarcoma. The child was categorised as being in the group lll, stage lll, intermediate risk category of embryonal RMS. Furthermore, we discuss about the clinical, radiological, immunohistochemical findings, and management of the aforementioned RMS case.

Key words: Rhabdomyosarcoma, cystoprostatectomy, immunohistochemistry, chemotherapy
Vascularized Fibular Graft for Non-Union of Tibial Long Bone with Acute Exacerbation Osteomyelitis in Pediatric Patient: A Case Report
Authors: Suarjaya Putra Agus , Bramantya Karna Made , Yuda Asmara AA Gde
Published: April 2024

Introduction: Osteomyelitis has more consolidated data in the medical literature, and is considered a predominantly pediatric disease, with 85% of patients aged below 17 years. Debridement is necessary for treatment, sometimes causes a bone defect. Vascularized bone grafts, like the vascularized fibular graft as surgical management for long bone osteomyelitis, that may maintain their intrinsic blood supply, speed up bone healing, and promote bone hypertrophy. This case report aims to evaluate about osteomyelitis on the right tibial bone with treated by vascularized fibular graft.
Case of presentation: A 4 years old female Balinese complained of swelling in the right leg from 8 months ago. The physical examination of right leg region revealed swelling over middle part of leg, scar post-operative and redness over middle part and tenderness around swollen soft tissue. On laboratories examination revealed an elevated CRP (26) and an elevated WBC (15,420). Meanwhile, On X-ray examination revealed suggestive osteomyelitis on the right tibial bone. We decided to performed surgical approach by using vascularized fibular graft to tibial bone infected. The patient was not complaint after surgery, and she undergo to follow rehabilitation protocol.
Discussion: VFF seems to be a valuable reconstructive technique for the treatment of osteomyelitis in tibial bone. The indication for VFF is skeletal defect greater than 6 cm in length. Fibular osteocutaneous is the most commonly used as vascularized bone graft clinically.
Conclusion: In conclusion, this case describes a rare presentation of spontaneous osteomyelitis of the tibial bone. A vascularised bony reconstruction with a VFF graft was performed. There was no complications following surgery in this patient.

Key words: Osteomyelitis, vascularized fibular graft, tibial bone, long bone, graft.
Innovative Solutions for Challenging Anatomical Traits: Comparing Different Hollow Denture Fabrication Techniques
Authors: Shah Rupal , Chheda Ekta , Tank Bansri
Published: April 2024

The core tenets of complete denture treatment are retention, stability, and support with acceptable aesthetics and good speech. For patients with specific anatomical traits such as highly resorbed ridges, long lip length, and increased interridge distance, the principles are often compromised with conventional dentures. Conventional dentures might add to weight, provide inappropriate retention, and thus, in turn, transfer abnormal forces to underlying hard and soft tissues hastening the process of residual ridge resorption. To manage the complication, hollowing the denture seems a fair alternative. Hollow denture provides several advantages like reduced weight, balanced force distribution, improved retention, and slow ridge resorption. This article presents several ways of crafting hollow dentures with the aim of preserving the underlying tissues, enhancing denture performance, and minimizing bone resorption.

Key words: Hollow denture, Caramel, Glycerin, Thermoplastic, Chocolate
Arduino Based Simulation and Mathematical Modelling for Lower Limb Exoskeleton
Authors: Sharma Rajnish Kumar , Vashist Devendra , Devakumar John
Published: April 2024

Normal Human Locomotion is amongst the biggest challenge for ensuring the rehabilitation of Persons with Locomotor Disabilities (PwLDs). Suitably designed, developed automated featured orthotic intervention is the present need of rehabilitation. There are numerous types of automation systems for lower limb exoskeleton (LLE). Control systems of LLE technology has undergone significant advancements in the last decade, incorporating various interdisciplinary areas and improving several aspects of design and functionality. In the present study, the schematic and mathematical modelling for the LLE has been done. In order to capture the schematic of the Arduino based controller and associated circuitry the Proteus simulation software is used. All the stages of the gait cycles i.e. heel-strike, foot-flat, mid-stance, heel-off, toe off, acceleration, mid-swing and deceleration have been successfully performed by using Arduino based software.

Key words: Orthotics, Lower Limb Exoskeleton, Controllers, Rehabilitation devices, Arduino, Locomotor disabilities
The content of heavy metals in the soils of the urban ecosystem Balti (Republic of Moldova)
Authors: Ţugulea Andrian , Stegărescu Vasile , Mogîldea Vladimir , Bulimaga Constantin , Prodan Petru , Portarescu Anastasia
Published: April 2024

Along with the development of human activity, the content of heavy metals in the soil also increases. In this paper, the content of heavy metals in the soils of the Balti urban ecosystem was evaluated. Samples were taken from 30 research sites, soil type and content of total forms of heavy metals (Zn, Cu, Ni, Pb and Cr) were determined. The sites with exceedances of the alert and intervention thresholds on the content of these metals have been determined. Thus, for Zn, exceedances of the alert threshold were found in a single site, and for Pb in 8 sites. It was noted that in the researched sites, due to the low alkaline pH of the soil, the increased concentrations of heavy metals do not represent a threat for the biotic components.
The empirical study on the results of the certification of enterprises from the Republic of Moldova in the ISO 22000 and ISO 22005 systems
Authors: Găină Boris , Fedorciucova Svetlana , Cobirman Galina
Published: April 2024

The European Union's food safety policy aims to protect consumers' health by ensuring compliance with production and control rules, hygiene of agri-food products and preventing their contamination with harmful substances. In its first stage, this objective can be applied in the Republic of Moldova, an EU candidate country, by implementing the ISO 22000 and ISO 22005 food safety management system, which establishes the basic requirements for the design and application of a traceability system for food and agri-food products. The study focused on identifying food and agri-food enterprises in the Republic of Moldova, which are certified by the ISO 22000 and ISO 22005 international standards. The advantages of these certifications and the barriers encountered were identified as well. In order to achieve this objective, there was carried out the survey according to the Computer Assisted Web Interviewing (CAWI) method, based on the completion of an online questionnaire created with the help of Google Drive.
The role and competences of local public authorities in migration management
Authors: Filipov Ina
Published: April 2024

The article analyzes the role of local public administration in managing migration at the level of a territorial community. It has to be mentioned that the author will refer to the way in which the local public administration intervenes in policy processes with an impact on reducing the negative effects of migration. In this context, the author considered relevant the analysis of the legal framework and public policies aimed at managing the phenomenon of migration at the local level. It was examined to what extent programs and policies developed at the national level are implemented at the local level and to what extent they represent support for strengthening the capacity of local authorities to manage the migration phenomenon, expressed in skills and areas of activity.
Moldovan Democratic Republic and the imperative of national unity (1917–1918)
Authors: Cojocaru Gheorghe
Published: April 2024

The present study argues that the Union of Bessarabia with the mother country, Romania, on March 27, 1918 gave expression to the natural tendency of Bessarabian Romanians to return to the ancestral hearth, representing in the complex circumstances of 1918 an authentic salvation not only for the national being in Bessarabia, but also for its consolidation and expansion democratic values throughout the Romanian space. The author emphasizes that the determining importance of Bessarabia's return its motherland made the dissolution of the Moldavian Democratic Republic perceived as a moment of inevitable separation, the popular hopes being tied to the Romanian state from now on. It is mentioned that the embryonic statehood of the territory between Prut and Dniester, as an expression of national self-determination, was a useful, important and legitimate vehicle and means in the complicated process of unchaining and finding the two banks of the Prut River. It is concluded that giving up a statehood that they did not have the resources to fully assume, which could become an easy prey for expansionist desires, the Romanians from Bessarabia, as well as the neighboring ethnic groups, have gained, instead, an entire country, part of the free European space.
Evaluation of Zinc acetate in decreasing anxiety like behavior in Swiss Albino Mice using behavior model
Authors: G Sasikala , R Praveena , A Meeradevi
Published: April 2024

Anxiety disorder is one of the most commonly occurring mental health conditions with less visibility leading to profound disability. Zinc, one of the most ubiquitous trace elements, has been identified to interact with the glutamate and GABAA receptors. This study was conducted to assess the anxiolytic activity of zinc acetate using a various behavioural model. Swiss albino mice were used in this study. The mice were randomised into 5 groups and were treated with control- normal saline, Diazepam as a standard drug, zinc acetate (10 and 20mg/kg) and zinc acetate 10mg/kg + Diazepam. Their anxiety like behaviour was assessed using elevated plus maze. In the elevated plus maze, zinc acetate at 20mg/kg and zinc acetate 10mg/kg + Diazepam showed increased amount of time spent in the open arm and also the number of entries into the open arm. Statistical analysis was performed using unpaired t- test. In conclusion, zinc acetate decreases anxiety like behaviour in mice and also potentiates the action of Diazepam.
Effect of Mucuna cochinchinensis seed extract on Alloxan-Induced Diabetic Experimental Rats
Authors: K Natarajan , C Nisha Shri , N Kumaresh Jawahar , M Niranjan Shakthi
Published: April 2024

Objective: Mucuna cochinchinensis (Fabaceae)is a widely grown twiner that has been used in the traditional medicine for treating many ailments. The objective of the present study was to evaluate the hypoglycemic effects of ethyl acetate extract of M. cochinchinensis seeds on alloxan-induced diabetic rat models. Materials and Methods: M.cochinchinensis seeds were collected and macerated with ethyl acetate to obtain ethyl acetate extract of M. cochinchinensis (EMC). The obtained extract was subjected to preliminary phytochemical analysis using standard protocol and HPLC-MS study to identify the phytoconstituents present. Effect of EMC on parameters like blood glucose and plasma insulin levels were assessed using commercial kits in alloxan-induced experimental rats. Results: Preliminary phytochemical analysis of EMC showed the presence of alkaloids, flavonoids, terpenoids, saponins, tannins and glycosides. HPLC-MS study revealed the presence of 6-C-Pentosyl-8-C-hexosyl apigenin and kaempferol-3-O-rutinoside in EMC. EMC effect on alloxan-induced diabetic ratsblood glucose level on 1st, 7th and 14th day and plasma insulin levels were determined and was found to revert the blood glucose levels significantly (p<0.01). Conclusion: To conclude, EMC has potent efficacy in normalizing blood glucose and serum insulin concentration in alloxan induced diabetic rats.
Long-term Rapamycin Treatment Inhibit AKT Activity and Lower Intracellular Calcium Expression in Organotypic Hippocampal Slice Cultures Model of Epilepsy
Authors: Husna Machlusil , Handono Kusworini , Sujuti Hidayat , Aulanni’am Aulanni’am , Waafi Afiyfah Kiysa
Published: April 2024

Despite the development of anti-epilepsy drugs, drug-refractory epilepsy still becomes a challenging problem along with an increased incidence of epilepsy. To face that challenge and increase patients’ quality of life, treatment of epilepsy must effectively prevent epileptogenesis, not only symptomatic treatment. AKT signaling pathway was proven to have important roles in epilepsy through its function in the synaptic plasticity, neurogenesis, axon guidance, modulation of the glutamate transporter, and activation of the Ca2+ channel. AKT also activated mTOR signaling pathway as activator of mTORC1 and also effector of mTORC2. Several studies showed the ability of long-term rapamycin treatment to inhibit mTORC2. This study used organotypic hippocampal slice cultures (OHSC) and long-term rapamycin treatment was administered for 3, 5, 8, and 10 days at a dose of 20 nM after induction of epilepsy by low-Mg2+ medium administration for 40 minutes. Low-Mg2+ medium administration induced seizure activity in OHSC showed by significant increase in intracellular Ca2+expressionand also significantly increase AKT activity. After administration of long-term rapamycin treatment AKT activity and intracellular Ca2+expression were significantly reduced. The longer the treatment of rapamycin, the lower the AKT activity and intracellular Ca2+expression. Long-term rapamycin treatment has the potential to become a novel epilepsy drug through its ability to attenuate AKT activity and suppress the seizures proven by lower intracellular Ca2+expression.
Improved ResNet Models for Chronic Kidney Disease Prediction
Authors: D. Vetrithangam,
Published: April 2024

Chronic kidney disease (CKD), a consequential health issue that can deeply affect an individual's overall wellness, can be initiated by either kidney cancer or a gradual reduction in kidney function. As the chronic disease advances, it can reach a critical stage where only dialysis or surgery can save lives. Halting its progress becomes crucial. CKD patients also face a heightened risk of premature death. Early detection of associated conditions poses a challenging task for healthcare professionals aiming to prevent their onset. A unique deep learning model is presented in this work for the prediction of CKD. Many existing CKD prediction models have the drawbacks of producing less accuracy, mispredicting, utilizing more computation time, and using low-quality datasets or data with noise and missing values, leading to misprediction. So it is necessary to develop new techniques that give high predictions with less computation time. The objective of this research work is to build improved ResNet models for the prediction of chronic kidney disease and evaluate their performance in comparison to other cutting-edge machine learning and deep learning methods. This research work developed ResNet models such as improved ResNet 152v2 with inception, improved ResNet 101, and improved ResNet50 models that produced 99.90%, 96.53%, and 93.968% accuracy, respectively. The proposed ResNet models for CKD prediction will be useful to nephrologists and other medical professionals.
Recurrent Neural Networks for Image Captioning: A Case Study with LSTM
Authors: Devi K, Manish Sharma, R. N. Patil, Anurag Shrivastava Shailaja Sanjay Mohite, Suganthini. C, Arunarani AR, Lalitha
Published: April 2024

This research investigates the viability of Long Short-Term Memory (LSTM) systems, a subtype of Recurrent Neural Networks (RNNs), for picture captioning. Leveraging the MS COCO dataset, the study compares the execution of LSTM-based RNNs with Vanilla RNN, Gated Recurrent Unit (GRU), consideration components, and transformer-based models. Experimental comes about to illustrate that the LSTM-based RNN shows competitive execution, accomplishing a BLEU-4 score of 0.72, a METEOR score of 0.68, and a CIDEr score of 2.1. The comparative investigation uncovers its prevalence over Vanilla RNN and GRU, highlighting its capability to capture long-range conditions inside successive picture information. Moreover, the study investigates the effect of consideration instruments and transformer designs, exhibiting their potential improvements in the context-aware caption era. The transformer-based show outflanks all other models, accomplishing a BLEU-4 score of 0.78, a METEOR score of 0.72, and a CIDEr score of 2.5. The findings give important bits of knowledge toward the creating scene of picture captioning strategy, which makes LSTM-based RNNs solid and productive approaches for capturing worldly groupings in visual substance. In achieving these, the study provides a framework for future developments in hybrid models and manufacturing processes that push boundaries of smart image perception and understanding