bluuebunny/crossref_metadata_2025 huggingface dataset:
Delirium related distress experienced by nurses
Authors:   University of Porto, Baptista Inês , Teixeira Ana ,   University of Porto, Fontes Liliana ,   Instituto Politécnico de Saúde do Norte, Paiva José Artur ,   Centro Hospitalar Universitário São Joã, Fernandes Lia ,   University Porto
Published: July 2023

Background: Delirium is described as a distressful experience by patients and their families. Also, among healthcare staff, nurses caring for patients with delirium are the most at risk of high distress related to this syndrome. Aims: To assess nurses’ distress related to delirium and its specific symptoms and severity. To identify factors nurses’ sociodemographic and psychological characteristics and professional experience, that may be associated to this distress. Methods: A prospective study was carried out with nurses caring older adults with delirium in Intensive Care Medicine Service. Distress related to delirium, global psychological distress and burnout in nurses were measured with Delirium Experience Questionnaire, Kessler Psychological Distress Scale and Copenhagen Burnout Inventory, respectively. Results: Eighteen nurses were included (mean age=32 years; 89% women). About 46% of the nurses classified the experience of caring for patients in delirium as moderately distressing. Disorientation and psychomotor agitation were the most distressing symptoms. High distress related to delirium was associated with greater personal (p=0.040) and work-related burnout (p=0.020), and more global psychological distress (p=0.007). Conclusion: Caring for patients with delirium is distressing for nurses, particularly if the disorientation and psychomotor agitation are present and if nurses presented high burnout or psychological distress. This study highlights the need for development of education and support strategies for all professionals dealing with these patients.
Solidão, depressão e utilização das TIC em idosos portugueses
Authors:   Univ Coimbra, Rodrigues Ana Patrícia , Duarte Jéssica ,   Univ Coimbra, Oliveira Sónia ,   Univ Coimbra, Costa José Joaquim ,   Univ Coimbra, Matos Ana Paula ,   Univ Coimbra
Published: July 2023

Contexto: A população idosa enfrenta dificuldades crescentes decorrentes de solidão, depressão e isolamento social. A literatura tem evidenciado o potencial da utilização das TIC para atenuar o sofrimento psicológico e melhorar a qualidade de vida. Objetivos: O presente estudo pretendeu analisar as relações entre sentimentos de solidão, sintomatologia depressiva e impacto da utilização e atitude face às TIC, em idosos. Metodologia: Trata-se de um estudo transversal que incluiu 669 sujeitos, com idades entre os 60 e 94 anos. Através de instrumentos de autorresposta avaliou-se a presença de sentimentos de solidão (UCLA-LS), sintomatologia depressiva (GDS-15) e a utilização e atitude face às TIC. Resultados: As mulheres evidenciaram níveis mais elevados de sintomatologia depressiva e sentimentos de solidão. Os idosos com mais de 80 anos relataram maiores níveis de solidão (na subescala Afinidades) e a faixa etária entre os 60-69 anos apresentou uma maior taxa de utilização das TIC. A presença de sentimentos de solidão relacionou-se com maiores níveis de sintomatologia depressiva e a utilização das TIC associou-se com menos sintomatologia depressiva. Conclusões: O envelhecimento pode ser vivido com menos sintomatologia depressiva se os idosos se sentirem menos isolados. A utilização das TIC, como ferramenta de comunicação, pode ter um impacto positivo no seu bem-estar psicológico, pois associa-se a menores níveis de depressão.
Effectiveness of crisis resolution and home treatment teams in mental health crisis: a systematic review protocol
Authors:   Escola Superior de Saúde Atlântica, Tomás Margarida , Soares Marisa ,   Centro de Investigação, Inovação e Desenvolvimento em Enfermagem de Lisboa, Martins Vânia ,   Serviço de Psiquiatria, Hospital Garcia de Orta, Monteiro Maria ,   UCC Saúde a Seu Lado, Monteiro Carlos ,   Unidade de Psicogeriatria, Centro Hospitalar Psiquiátrica de Lisboa
Published: July 2023

Background: People with mental health crises may need intensive care support that, in many countries, implies a psychiatric hospitalization that may negatively affect the individual. Furthermore, it involves the individuals’ removal from their daily spaces, which implies an adaptive effort when returning to the community. In order to reduce the treatment’s impact of a mental health crisis, Crisis Resolution or Home Treatment (CRHT) Teams have been providing an alternative to inpatient treatment. Aim: To analyze and highlight CRHT teams’ effectiveness in reducing days of treatment, relapse, and rehospitalization of adults (18-65 years) compared to treatment as usual defined as inpatient treatment. Methods: We will develop a systematic review of the current literature by the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) 2019 Statement. Two authors will independently conduct study inclusion, data extraction, quality, and bias risk assessments. We will include experimental study designs like randomized clinical trials, non-randomized, quasi-experimental, before and after studies, prospective and retrospective cohort studies, and case-control studies involving working-age adults (18-65 years) irrespective of culture, ethnicity, or mental health diagnosis. Results: We will include primary outcomes like days of treatment, relapse (as defined by each study), and rehospitalization. Secondary outcomes will be service user satisfaction, dropout rate, and the proportion of patients with adverse events (suicide, self-harm, or aggression/violence). Conclusions: This study will allow evidence to determine the need to create and encourage the implementation of CRHT teams to provide an effective alternative response to psychiatric hospitalization.
Perception of Brazilians on the Sustainable Development Goals (SDGs) and the Low-Carbon Economy
Authors: Ribeiro Rossana Parizotto , Espuny Ana Lígia Gil , Hermes Andrea Burmeister Morais , Andriolli Elaine Marisa
Published: July 2023

Objective: The objective of this study is to analyze the significance of Sustainable Development Goals (SDGs) in the context of the Low Carbon Economy (LCE) through a quantitative and descriptive approach. The research aims to identify and understand the relationships between the 17 SDGs and their impact on the promotion of sustainable development, particularly in mitigating climate change-related issues.
Method: The research employed a quantitative and descriptive methodology, utilizing a survey conducted in the state of Rio Grande do Sul (RS), Brazil. The survey was designed to gather data from respondents representing civil society, government, and companies in the region. Participants were asked to evaluate the importance and influence of each of the 17 SDGs on the Low Carbon Economy.
Results: The research findings reveal substantial relationships between the 17 Sustainable Development Goals (SDGs) and the Low Carbon Economy (LCE), as perceived by the respondents. The results indicate that all SDGs play a significant role in influencing the LCE. These findings emphasize the interconnectedness of sustainable development goals and their potential to drive the transition to a Low Carbon Economy.
Conclusions: The study highlights the crucial role of Sustainable Development Goals in promoting a Low Carbon Economy. By fostering the use of renewable energy sources and sustainable practices, the LCE offers a solution to reduce environmental damage and work towards achieving sustainable development.
Factors Associated With Atopic Dermatitis In Elementary School Children In Suburban Area In Indonesia: Original Research
Authors: Gunawan Catherine , Satriajaya Anthony , Vatvani Akhil Deepak , Waren Kalis , Angela Angela , Broto Resza , Kalumpiu Jane Florida , Tan Sylvia
Published: July 2023

Background: There was limited data of Atopic Dermatitis (AD) prevalence and its associated factors in Indonesia. Therefore, the aim of this study was to identify and evaluate the AD prevalence and factors associated with AD in elementary school children in suburban area in Banten.

Methods: A cross-sectional study was conducted in 3 elementary schools children age 6–7 years old who were randomly selected. Information was obtained through an Indonesian version of the International Study of Asthma and Allergies in Childhood questionnaire (ISAAC).

Results: From 304 school children in semi-urban area, AD was reported as ever had an itchy rash which was reccurent for at least 6 months in 17.4% of the children, 19.5%  of the children had this itchy rash at any time in the past 12 months, and 11.4 % reported doctor-diagnosed AD. The factors found to be associated with an increased risk of AD were allergic rhinitis (OR 2.151 CI: 1.086-4.261), history of premature birth (<37 weeks) (OR 5.306, CI:1.577-17.858), exclusive breastfeeding (OR 3.126 CI:1.314-7.439), and food allergy (OR 2.912 CI:1.386-6.119).

Conclusion: The results of this study showed that allergic rhinitis, history of premature birth (<37 weeks), exclusive breastfeeding, and food allergy were factors associated with AD in Indonesian schoolchildren. 
UPAYA MENGEMBANGKAN PROFIL KOMPETENSI PESERTA DIDIK DI ERA SOCIETY 5.0 DALAM PERSPEKTIF ILMU PENGETAHUAN SOSIAL [EFFORTS TO DEVELOP STUDENT COMPETENCY PROFILES IN THE SOCIETY 5.0 ERA FOR SOCIAL STUDIES EDUCATION]
Authors: Chrismastianto Imanuel Adhitya Wulanata , Lasmawan I Wayan , Suharta I Putu , Ratnaya I Gede
Published: July 2023

Abstract

The emergence of the Society 5.0 era opens opportunities as well as increasingly complex challenges for the existence and progress of education to support communication and information technology in the learning process which is expected to produce students who are adaptive to the social changes around them. However, the lack of students' competence regarding access to learning and technology remains an educational challenge in this era. The purpose of this article is to identify and develop competency profiles of students in the Society 5.0 era for social studies education. The research method used is qualitative with a literature review approach that is relevant to the competency profile of students in terms of character, citizenship, critical thinking, creative thinking, collaboration, and communication. The analysis results show that the six competencies are effectively implemented in schools by educators through concrete efforts to improve the quality of learning models, provide space for developing student competencies, and consistently make efforts to strengthen students' character, values, and ethics.

Bahasa Indonesia Abstrak

Munculnya era Society 5.0 membuka peluang sekaligus tantangan yang semakin kompleks bagi eksistensi dan kemajuan dunia pendidikan dengan dukungan teknologi komunikasi dan informasi dalam proses pembelajaran yang diharapkan mampu mencetak peserta didik yang adaptif terhadap perubahan sosial di sekitar tempat tinggalnya. Namun, minimnya kompetensi peserta didik terhadap akses pembelajaran dan teknologi masih menjadi tantangan tersendiri bagi dunia pendidikan di era tersebut. Tujuan penulisan artikel ini untuk melakukan identifikasi dan mengembangkan profil kompetensi peserta didik di era Society 5.0 dalam perspektif Ilmu Pengetahuan Sosial (IPS). Metode penelitian yang digunakan adalah kualitatif dengan pendekatan kajian literatur yang relevan dengan profil kompetensi peserta didik dalam hal karakter, kewarganegaraan, berpikir kritis, berpikir kreatif, kolaborasi, dan komunikasi. Hasil analisis menunjukkan bahwa keenam kompetensi tersebut efektif diimplementasikan di sekolah oleh pendidik melalui upaya konkret peningkatan kualitas model pembelajaran, penyediaan ruang pengembangan kompetensi peserta didik, serta secara konsisten melakukan upaya penguatan karakter, nilai, dan etika peserta didik.
PENGARUH AKTIVITAS MEDIA SOSIAL TERHADAP KESEHATAN DAN KESEJAHTERAAN GURU DALAM MODEL EFFORT REWARD IMBALANCE (ERI) [THE EFFECTS OF SOCIAL MEDIA ACTIVITIES ON TEACHERS’ HEALTH AND WELL-BEING IN THE EFFORT REWARD IMBALANCE (ERI) MODEL]
Authors: Prissly Robby , Kho Ardi
Published: July 2023

Abstract

Past research reveals the positive effect of social media in reducing stress and providing social support to promote health and wellbeing. However, research in the teacher’s context is still limited and thus requires further investigation. This research is aimed at measuring the effect of social media activities on the health and wellbeing of active teachers currently teaching grades 7-12 in a Christian school in Indonesia. The Effort Reward Imbalance (ERI) model is used to measure the stress level while the Teacher Subjective Wellbeing Questionnaire (TSWQ) is used to measure the health and well-being of 68 targetted teachers. Data is analyzed and processed using the PLS-SEM method. The results show that social media activities have a positive effect on the health and well-being of teachers when mediated by teacher reward while teacher effort has a negative effect on the health and well-being of teachers.

Bahasa Indonesia Abstrak

Beberapa penelitian mengungkapkan pengaruh positif media sosial dalam mengurangi stres dan menjadi sumber social support yang meningkatkan kesehatan dan kesejahteraan. Namun demikian penelitian dalam konteks guru masih terbatas sehingga membutuhkan penggalian lebih jauh. Penelitian ini bertujuan untuk mengukur pengaruh aktivitas media sosial terhadap kesehatan dan kesejahteraan guru yang aktif mengajar di sekolah Kristen di Indonesia pada jenjang SMP/SMA. Model Effort Reward Imbalance (ERI) digunakan untuk mengukur tingkat stres yang dihadapi sementara Teacher Subjective Wellbeing Questionnaire (TSWQ) digunakan untuk mengukur kesehatan dan kesejahteraan dari 68 guru yang menjadi target penelitian. Pengolahan dan analisis data dilakukan dengan metode PLS-SEM. Hasil penelitian menunjukkan bahwa aktivitas media sosial berpengaruh positif terhadap kesehatan dan kesejahteraan guru ketika dimediasi oleh teacher reward sementara teacher effort berpengaruh negatif terhadap kesehatan dan kesejahteraan guru.
PREFERENSI PEMILIH MUSLIMS DALAM PEMILIHAN KEPALA DAERAH SERENTAK 2020 DI SUMATERA BARAT DAN SULAWESI UTARA
Authors: Salim Delmus
Published: July 2023

This article focuses on the influence of religious sentiment in the simultaneous regional head elections in West Sumatra and North Sulawesi in 2020. This article discusses political behavior that is influenced by the religion of voters in provinces with a Muslim majority and minority. Data collection was carried out by survey using interviews and online applications with Muslim voters on the reasons that influenced them in choosing regional heads. This study reveals that religious sentiments have a strong influence on Muslim political behavior in West Sumatra and not in North Sulawesi. This Muslim political behavior is related to the history of colonialism in Indonesia and the management of religious resources in the two areas studied. Regional heads in Muslim-majority and minority areas greatly influence the dynamics of religious resources in the areas they lead. This study, in turn, highlights the importance of developing strategies for managing religious resources in Indonesia.
Anesthetic Considerations in Patients with Mitochondrial Disorders
Authors: Maritska Ziske , Parisa Nita , Karina Mathius , Putra Marco Manza , Eliska Noviyanti , Irga Muhammad , Manurung Maya Rina Santara , Saputra Andre
Published: July 2023

Introduction: Mitochondrial Disorders (1/4,000 patients) are rare and caused by dysfunctional mitochondria. Anesthetic consideration in patients with Mitochondrial Disorders involves careful preoperative and perioperative observations. Objective: To provide a brief insight into how general anesthetics interfere with mitochondrial energy formation pathways and help form precautions for anesthesiologists when managing patients with Mitochondrial Disorder. Review: Mitochondrial Disorder patients would experience various health problems, such as damaged cardiac functions, neurology systems, and musculoskeletal functions due to energy production disruptions by dysfunctional mitochondrial processes. Moreover, patients with Mitochondrial Disorders exhibit hyperreactivity to volatile anesthetics. Summary: No anesthetic strategies are found to be safe in patients with Mitochondrial Disorder yet. Therefore, anesthesiologists should remain alert when monitoring fluid choices and managing patient temperature with Mitochondrial Disorders.
Systematic Review and Meta-Analysis of Paracervical Blocks as A Perioperative Strategy in Reducing Postoperative Pain in Patients Undergoing Laparoscopic Hysterectomy
Authors: Nabiel Rifaldy , Suseno Daniel Alexander , Hadisubroto Yonas , Gemawan Taufiq , Anindito Putri Aurellia Nuraini , Salsabila Syadza , Sari Eprila Darma
Published: July 2023

Introduction: Perioperative strategies to reduce postoperative pain are important for enhancing patient satisfaction. However, further research and trials has sparked ongoing debates of various strategies regarding efficacy and safety. Objective: This study aims to improve evidence-based strategies regarding the effect of paracervical anaesthetic blocks in patients undergoing laparoscopic hysterectomy. Materials and Method: A systematic literature search was conducted through PubMed, Google Scholar, and ScienceDirect for RCTs in laparoscopic hysterectomy patients administered paracervical blocks and those given placebos. The quantitative analysis of pooled relative risk and mean difference with a 95% confidence interval were performed using the Review Manager 5.4 software in the random-effects model or fixed-effects model forest plot. Results: Based on four RCTs included in the analysis, there were significant differences in overall postoperative pain scores assessed by VAS (Visual Analogue Scale) [MD = -0.82, 95%CI (-1.47 to -1.06), p = 0.01]. The subgroup analysis also showed significant differences in VAS pain scores at 30 min and 1 hour post-operation [MD = -2.13, 95% CI (-3.09 to -1.16), p = 0.0001] and [MD = -2.55, 95% CI (-4.29 to -0.81), p = 0.004]. However, there were insignificant results in adequate pain control [RR = 7.90, 95%CI (0.39 to 158.67), p = 0.18], length of hospital stay [MD = 0.01, 95%CI (-0.52 to 0.54), p = 0.96], additional analgesics requirement at 24 hours [RR = 0.88, 95%CI (0.55 to 1.39), p=0.58], and perioperative complications [RR = 0.90, 95%CI (0.56 to 1.47), p = 0.68].Conclusion: This meta-analysis provides evidence that the administration of paracervical block in patients undergoing laparoscopic hysterectomy is associated with a reduction of postoperative VAS pain score but not associated with the length of hospital stay, adequate pain control, additional analgesics requirement at 24 hours, and perioperative complications.
CORRELATION BETWEEN ADOLESCENT PREGNANCY WITH PREGNANCY COMPLICATIONS AT PUSKESMAS GALIS BANGKALAN REGENCY
Authors: Muthia Shani Shifa , Budi Amalia Rize , Erye Frety Endyka
Published: July 2023

Background: Adolescent pregnancy is a pregnancy that occurred between the age of 10-19 years. The survey in 2019 in Indonesia showed that the number of pregnant women aged 15-19 years reached 47 per 100 pregnancies. The anatomy of adolescent’s body is not ready yet for pregnancy or childbirth so complications can occur during pregnancy. This study aims to analyze the relationship between adolescent pregnancy and pregnancy complications at Puskesmas Galis Kabupaten Bangkalan. Method: This research used observational analytic with case control design. The population in this study were all women who had given birth in Puskesmas Galis Kabupaten Bangkalan in January-December 2022. The number of samples used was 42 people who were divided into case and control groups. The sampling technique used was consecutive sampling. The indipendent variable in this study was adolescent pregnancy and the dependent variable were pregnancy complications which included anemia, nutritional deficiency. Data collection was obtained from medical records. Statistical data analysis using chi square test. Result: The results showed that pregnancy complications in the adolescent group were 38,1% and in the reproductive age group 19%. The results of chi square test obtained a p value of 0,172 (p>0,05) which means that the test results were not significant. Conclusion: There is no relationship between adolescent pregnancy and pregnancy complications at Puskesmas Galis Kabupaten Bangkalan.
RELATIONSHIP BETWEEN KNOWLEDGE AND ATTITUDES TOWARDS ADHERENCE IN DETECTION OF CERVICAL CANCER
Authors: Sari Fadhilah , Mulawardhana Pungky , Sudaryanti Lestari
Published: July 2023

Background: Cervical cancer is an uncontrolled cell growth that occurs in the cervix caused by the Human Papilloma Virus (HPV) virus.  Early detection programs for cervical cancer can be done in several ways, including Visual Inspection of Acetic Acid (IVA), pap smear, colposcopy, cervicography, and pap net. This method has been shown to reduce the incidence of invasive cervical cancer by the amount and mortality of cervical cancer. The purpose of this study was to determine the relationship between knowledge and attitudes towards Women of Childbearing Age (WCA) compliance in early detection of cervical cancer at the Ulak Karang Health Center in Padang City. Method: Cross Sectional. The population in this study was all WCA mothers (19-69 years old) in the working area of the Ulak Karang Health Center in Padang City as many as 2,916 people with a total sample of 97 people taken using quota sampling. This research was carried out in the working area of the Ulak Karang Health Center, Padang City in May-July 2023. The variables in this study are knowledge, attitudes and compliance with IVA examination. Data were analyzed univariately, bivariately (chi square) and multivariate. Results: There was a significant association between knowledge and WCA compliance in early detection of cervical cancer (p value 0.000). There was a significant relationship between attitude and WCA compliance in early detection of cervical cancer (p value 0.000). The relationship between knowledge and attitudes towards adherence is that there is a significant relationship between knowledge and attitudes towards WCA adherence in early detection of cervical cancer (p value 0.000). Conclusion: There is a relationship of knowledge and attitudes towards WCA compliance in early detection of cervical cancer.
Analisis Inaportnet Terhadap Kepuasan Pengguna Jasa Dengan Kinerja Karyawan Sebagai Variabel Intervening Pada Perusahaan Pelayaran
Authors: Arisanti Dian , Widyawati Nur , Novitasari Dwi Fitri
Published: July 2023

Penggunaan Inaportnet memiliki manfaat seperti informasi tentang efektivitas dan efisiensi operasi di tempat, seperti kontrol perizinan, bongkar muat, rencana tambat, operator kapal tunda, dan lainnya. Inaportnet saat ini menyediakan INSW dengan informasi waktu tunggal. Penelitian ini dilakukan untuk menganalisis pengaruh kualitas sitem (X1), kualitas informasi (X2), kualitas pelayanan (X3) pada sistem Inaportnet terhadap kepuasan pengguna (Y) dengan melalui kinerja karyawan (X) sebagai variabel intervening. Jenis data yang digunakan pada penelitian ini adalah kuantitatif. Populasi didalam penelitian ini adalah karyawan manajemen PT Anugerah Tirta Samudra sedangkan sampel berjumlah 35 respoden dengan menggunakan teknik sampel jenuh. Data yang digunakan yaitu diperoleh dari data primer dan data sekunder. Teknik pengumpulan data dilakukan dengan menyebarkan kuesioner. Teknik analisis yang digunakan adalah analisis regresi linier berganda serta menggunakan uji path analysis yang digunakan untuk mengetahui adanya pengaruh langsung maupun tidak langsung dari varibel. Sebelum data dianalisis, dilakukan pengujian kualitas data dengan uji validitas dan reliabilitas. Hasil olah data menunjukkan item kuisioner bersifat valid dan semua variabel bersifat reliabel. Setelah itu dilakukan uji sobel untuk mengetahui adanya pengaruh yang dilakukan oleh variabel intervening. Berdasarkan hasil analisis dan pembahasan, hasil dari penelitian ini menunjukkan bahwa kualitas sistem (X1), kualitas informasi (X2), kualitas pelayanan (X3) berpengaruh signifikan secara parsial terhadap kepuasan pengguna (Y) dan kinerja karyawan (Z). Serta adanya pengaruh variabel intervening melalui kinerja karyawan yang berpengaruh terhadap kepuasan pengguna sistem Inaportnet.
UNDERSTANDING BEHAVIOURAL INTENTION OF EXPERIENCING VIRTUAL TOURISM DURING COVID-19: AN EXTENSION OF THEORY OF PLANNED BEHAVIOUR
Authors: Hamid Sheeba , Ali Ruksar , Sujood  , Jameel Syed Talha , Azhar Mohd , Siddiqui Samiha
Published: July 2023

Purpose – The overall purpose of this study is to assess consumers’ behavioural intentions regarding virtual tourism COVID -19 using the TPB. This work sought to assess the applicability of TPB utilising its foremost constructs, i.e., attitude, subjective norm, and perceived behavioural control, with the inclusion of perceived security. Design/Methodology – A web-based questionnaire was utilised to gather the data that was randomised. A link to a Google form was posted on the websites of travel companies offering virtual tours and other social networking sites from August 1, 2021, to September 15, 2021, resulting in 408 usable responses. The data were analysed via SEM using the programmes AMOS and SPSS, and statistical analysis was performed for the proposed hypotheses. Approach – This paper presents the latest findings and important details about consumers’ behavioural intentions regarding virtual tourism in a bid to provide insightful details for the tourism and travel sector in general and for travel agencies offering virtual tourism packages in particular. Findings – Research findings suggest that subjective norm and perceived safety influence people’s behavioural intentions toward virtual tourism as an alternate to on-site tourism. 52% of the variance in behavioural intention toward virtual tourism during the Corona virus period was explained by the factors as a whole. Originality – This study lends to the evaluation of consumer interest in virtual travel by linking the TPB variables to perceived safety, making it a novelty of its kind. So far as the authors are aware, no previous work in the Indian context has evaluated TPB by including a measure of perceived safety in its attempt to shed light on Indians’ behaviour toward virtual tourism.
Modelo complejo para la evaluación de la gestión de la calidad del aire en cinco ciudades del estado de Guanajuato, México
Authors:   Instituto Tepeyac de León, Salas-Rodríguez David
Published: July 2023

El objetivo del presente trabajo es proponer un modelo para la evaluación de la gestión de la calidad del aire (GCA) en cinco ciudades del estado de Guanajuato a modo de sistema complejo. Se aplicó la entropía como medida en la variabilidad de sus instrumentos de gestión, se utilizó el Índice de Variación Cualitativa (IQV) observado en las funciones y estrategias de cada unidad responsable de la calidad del aire (URCA) y el Índice de Coocurrencia de Códigos (ICC) para analizar los avances instrumentados que se reportaron en los informes del programa para mejorar la calidad del aire (PROAIRE). Los resultados se emplearon para crear un modelo de GCA que ubica a la URCA de cada una de las cinco ciudades dentro del espacio fase como un sistema complejo. Esto propone una solución a la diversidad de enfoques cualitativos, cuantitativos o mixtos para su estudio y a la falta o exceso de información relacionada con el estudio de la GCA.
First approach to microplastics occurrence in sandy beaches in the province of Islay (Arequipa), southern Peru
Authors:   Universidad Nacional de San Agustín de Arequipa, Luque-Fernández César Raúl , Alcelay Ibai ,   Universidad Nacional de San Agustín de Arequipa, Villegas Paredes Luis ,   Universidad Nacional de San Agustín de Arequipa, Bocardo-Delgado Edwin ,   Universidad Nacional de San Agustín de Arequipa
Published: July 2023

Plastic pollution in marine and coastal environments has been widely recognized as a growing environmental concern. Plastic particles generated mainly by the degradation of larger plastic debris have been called microplastics (< 5 mm), which are being widely studied in all regions of the world. In South America there has been a constant increase of the research on this topic mainly on the Pacific coast. Specifically, in Peru, the number of publications has also increased, but the northern and southern zones are not well studied. Due to the importance of determining the presence of these contaminants, especially in coastal regions, which are considered as repository environments for these plastics, it is necessary to establish baselines of their current situation. This research aimed to determine and characterize the presence of microplastic particles (< 5 mm) on five sandy beaches in the province of Islay in southern Peru and to consider the possible effect of the Tambo River mouth on the transport and deposition of microplastics on two adjacent beaches. Three sampling stations were determined for each selected beach, consisting of three to two quadrants (1 m2) sampled at 5 cm depth. The results confirm the presence of microplastics. A total of 304 particles were found, with an average density between 1 to 4 part/m2. The areas with the highest concentration of microplastic particles and frequency of occurrence were the beaches adjacent to the river estuary where the most frequent types of particles were fragments and fibers, followed by foams and films, but no pellets.
Antioxidant Determining Using an Electrochemical Method
Authors: Sukma Rani Melati , Iswantini Dyah , Nurhidayat Novik , Rafi Mohamad , Ariyanti Dita
Published: July 2023

Antioxidants are very beneficial for health because they protect the body from the effects of free radicals on various degenerative diseases caused by food contamination, air pollution, sunlight, etc. In general, methods for measuring the capacity of antioxidants generally use accurate meth-ods such as spectrophotometry and chromatography. Still, it takes time, sample preparation and must be done in a laboratory with particular expertise. Therefore, a new, more practical method needs to be developed for determining antioxidants, namely the electrochemical method. The electrochemical method is promising to develop because it has several advantages, including high sensitivity and fast response. The electrochemical method discussed in this article reviews sensors, biosensors, and nanosensors. This paper comprehensively analyzes contemporary developments in electrochemical biosensor techniques and antioxidant evaluation methodologies. The discussion centers on utilizing multiple biosensors. Electrochemical biosensors have been determined to be prevalent in analyzing food quality, assessing active factor functionality, and screening practical components. The present study outlines the difficulties linked with electrochemical bio-sensor technology and provides insights into the potential avenues for future research in this domain.
Oncolytic Viruses and Immune Checkpoint Inhibitors: The “Hot” New Power Couple
Authors: Lovatt Charlotte , Parker Alan L.
Published: July 2023

Immune checkpoint inhibitors (ICIs) have revolutionized cancer care and shown remarkable efficacy clinically. This efficacy is, however, limited to subsets of patients with significant infiltration of lymphocytes into the tumor microenvironment. To extend their efficacy to patients who fail to respond or achieve durable responses, it is now becoming evident that complex combinations of immunomodulatory agents may be required to extend efficacy to patients with immunologically “cold” tumours. Oncolytic viruses (OVs) have the capacity to selectively replicate within and kill tumour cells resulting in the induction of immunogenic cell death and the augmentation of anti-tumour immunity and have emerged as a promising modality for combination therapy to overcome the limitations seen with ICIs. Pre-clinical and clinical data has demonstrated that OVs can increase immune cell infiltration into the tumour and induce anti-tumour immunity, thus changing a “cold” tumour microenvironment that is commonly associated with poor response to ICIs, to a “hot” microenvironment which can render patients more susceptible to ICIs. Here, we review the major viral vector platforms used in OV clinical trials, their success when used as a monotherapy and when combined with adjuvant ICIs, as well as pre-clinical studies looking at the effectiveness of encoding OVs to deliver ICIs locally to the tumour microenvironment through transgene expression.
Constraints, Interventions and Prospects for Improving Pearl Millet (Pennisetum glaucum L) Production in the State of Eritrea - A Review
Authors: Okumu Oliver Otieno , Wendot Philip Kibet , Abraha Tesfamichael
Published: July 2023

Pearl millet (Pennisetum glaucum L.) is the second most important cereal grown in Eritrea after sorghum (Sorghum bicolor L.) grown under low input systems by small scale farmers. The crop utilizes soil moisture efficiently and has ability to tolerate soil toxicity and extreme temperatures than other cereals. It is a sustenance and food security crop important for its nutritive and cultural value and provides dietary energy and nutrition. However, despite the positive attributes and qualities of pearl millets for the present and future agriculture, production has been low. We attribute this to inadequate rainfall distribution, poor crop management by poorly resourced farmers, unavailability and high prices of farm inputs such as fertilizer and pesticides and low adoption of improved varieties by the farmers. This review outlines the constraints, interventions the government/ farmers have and can implement and the prospects of actions that can improve pearl millet production. As much as there have been efforts by the government and stakeholders to address these challenges and improve productivity of pearl millet, more needs to be done to meet the increasing demand of the increasing populations. This will enable farmers to intensify and diversify their agricultural systems and improve food security situation in the country. Unless a combined effort in soil fertility improvement, policies to promote use of modern varieties and conservation of and promotion of this crop biodiversity, the potential of this crop as famine and poverty alleviation among the rural poor will not be realized.
Analysis of Feedback-Based Technology in Alzheimer´s Disorder by a Randomized Experimental Pilot
Authors: Benitez-Lugo Maria Luisa , Vazquez-Marrufo Manuel , Pinero-Pinto Elena , Chamorro-Moriana Gema , Perez-Cabezas V , Suarez-Serrano Carmen
Published: July 2023

Background: Alzheimer's disease causes great changes, with the prefrontal cortex be-ing frequently damaged zones, affecting physical and cognitive behavioural and compromising autonomy and quality of life. Objective: To evaluate the effectiveness of feedback-based tech-nology on the improvement of physical-cognitive capacities in Alzheimer. Methods: Forty pa-tients with Alzheimer were recruited from the Santa Elena Alzheimer's Association, Seville, of which 15 ended up being pilot participants, divided randomly into controls (8) and experi-mental (7). They were evaluated with: Cognitive Mini-Examination Scale, Oddball Test and At-tention Network, Berg Scale, Tinetti, Timed up and Go and Geriatric Deterioration Scale. The experimental group was treated with feedback-based technology under the supervision of physiotherapists, during 16 thirty-minute sessions, twice a week. The control group performed their usual care. Result: A significant improvement was observed in the experimental group (Cognitive Mini-Examination and Tinetti). In the group of control, a worsening of physical and motor skills was evidenced because of the degenerative disease. Discussion/Conclusion: This treatment could be a strategy to keep the patient in early stages for longer, and improve quali-ty of life delaying dependency. It creates intergenerational bonds and use at home to promote treatment adherence.
Utility of the Serum Protein Electrophoresis in the Opportunistic Screening for the Deficiency of Alpha-1 Antitrypsin
Authors: Fernández-Gomez Beatriz , Menao-Guillén Sebastian , Fernandez Gonzalez Ayala , Arruebo Muñio Maria , Ramos Alvarez Monica , Inda Landaluce Mercedes , Castillo Arce Maria Angeles , Torralba-Cabeza Miguel-Angel
Published: July 2023

Background: Deficiency of alpha-1 antitrypsin (AAT1) is a rare disorder that represents a significant health threat and early diagnostic a priority issue. We investigate the usefulness of the serum protein electrophoresis (SPE) as an opportunistic screening tool for AAT1 deficiency. Methods: For 6 months, all SPE carried out for any reasons were evaluated in our center. In those with less than 3% of Alpha-1 globulins, AAT1 concentrations were studied. The SERPINA1 gene was subsequently sequenced in those subjects displaying concentrations below 100 mg/dL. Results: Out of the total, 14 patients (0.3%) were identified with low AAT1 concentrations, 11 of them agreeing to enter the study. Of those, mutations in the SERPINA1 gene were discovered in 10 subjects (91%). Heterozygous mutations were detected in 7 patients; 3 had the c.1096G>A mutation (p.Glu366Lys; Pi*Z), 2 the c.863A>T mutation (p.Glu288Val; Pi*S), one the c.221_223delTCT mutation (p.Phe76del; Pi*Malton) having the last one the c.1066G>A (p.Ala356Thr) mutation not previously described. Finally one patient had the c.863A>T mutation in homozygosis whereas two double heterozygous patients c.863A> T/ c.1096G>A were detected. Conclusions: an altered result in the concentration of AAT1 anticipates a mutation in the SERPINA1 gene in a manner close to 91%. The relationship between a decrease in the Alpha-1 globulin band of the SPE and an alteration in the AAT1 concentration is direct in basal states of health. The SPE is presented as a highly sensitive test for opportunistic screening of AAT1 deficiency.
Broiler Mobility Assessment Via a Semi-Supervised Deep Learning Model and Neo-Deep Sort Algorithm
Authors: Jaihuni Mustafa , Gan Hao , Tabler Tom , Prado Maria , Qi Hairong , Zhao Yang
Published: July 2023

Mobility is a vital welfare indicator which may influence broilers’ daily activities. Classical broiler mobility assessment methods are laborious and cannot provide timely insights into their conditions. Here, we proposed a semi-supervised Deep Learning (DL) model, YOLOv5, combined with Deep Sort algorithm conjoined with our newly proposed algorithm, Neo-Deep Sort, for individual broiler mobility tracking. Initially, 1,650 labeled images from five days were employed to train the YOLOv5 model. Through semi-supervised learning (SSL), this narrowly trained model was then used for pseudo-labeling 2,160 images, of which 2,153 were successfully labeled. Thereafter, the YOLOv5 model was fine-tuned on the newly labeled images. Lastly, the trained YOLOv5 and the Neo-Deep Sort algorithm were applied to detect and track 28 broilers in two pens and categorized them in terms of hourly and daily traveled distances and speeds. SSL helped in increasing the YOLOv5 model’s mean Average Precision (mAP), in detecting birds, from 81% to 98%. As compared with the manually measured covered distances of broilers, the combined model provided individual broiler's hourly moved distances with a validation accuracy of about 80%. Eventually, individual and flock level mobilities were quantified while overcoming the occlusion, false and miss detection issues.
Multiple Roles of RUNX Gene Family in Hepatocellular Carcinoma and Their Potential Clinical Implications
Authors: Krajnović Milena , Kožik Bojana , Božović Ana , Jovanović-Ćupić Snežana
Published: July 2023

Hepatocellular carcinoma (HCC) is one of the most frequent cancers in humans, characterised by high resistance to conventional chemotherapy, late diagnosis, and high mortality rate. It is necessary to elucidate the molecular mechanisms involved in hepatocarcinogenesis to improve diagnosis and treatment outcomes. The Runt-related (RUNX) family of transcription factors (RUNX1, RUNX2, and RUNX3) participates in cardinal biological processes and play paramount roles in the pathogenesis of numerous human malignancies. Their role is often controversial as they can act as oncogenes or tumour suppressors, dependent on cellular context. Evidence shows that deregulated RUNX genes may be involved in hepatocarcinogenesis from the earliest to the latest stages. In this review, we summarise the topical evidence on the roles of RUNX gene family members in HCC. We discuss their possible application as non-invasive molecular markers for early diagnosis, prognosis, and development of novel treatment strategies in HCC patients.
Numerical Simulation of PFRC Fracture Subjected to High Temperature by Means of a Trilinear Softening Diagram
Authors: Suárez Fernando , Enfedaque Alejandro , Alberti Marcos G. , Gálvez Jaime C.
Published: July 2023

Fibre reinforced concrete (FRC) has been used for decades in certain applications of the construction industry, such as tunnel linings and precast elements, but has experienced an important progress in recent times, boosted by the inclusion of guidelines for their use in some national and international standards. Traditional steel fibres have been studied in depth and their performance is well known although in recent years new materials have been proposed as possible alternatives. Polyolefin macro-fibres, for instance, have proven to enhance the mechanical properties of concrete and the parameters that define their behaviour (fibre length, fibre proportion or casting method, for instance) have been identified. These fibres overcome certain traditional problems related to steel fibres, such as corrosion or their interaction with magnetic fields, which can limit the use of steel in some applications. The behaviour of polyolefin fibre reinforce concrete (PFRC) has been numerically reproduced with success through an embedded cohesive crack formulation that uses a trilinear softening diagram to describe the fracture behaviour of the material. Furthermore, concrete behaves well under high temperatures or fire events, especially when it is compared with other construction materials, but the behaviour of PFRC must be analysed if the use of these fibres is to be extended. To this end, the degradation of PFRC fracture properties has been recently experimentally analysed under a temperature range between 20ºC and 200ºC. As temperature increases, polyolefin fibres modify their mechanical properties and their shape, which reduce their performance as reinforcement of concrete. In this work, those experimental results, which include results of low (3 kg/m3) and high (10 kg/m3) proportion PFRC specimens, are used as reference to study the fracture behaviour of PFRC exposed to high temperatures from a numerical point of view. The experimental load-deflection diagrams are reproduced by modifying the trilinear diagram used in the cohesive model, which helps to understand how the trilinear diagram parameters are affected by high temperature exposure. Finally, some expressions are proposed to adapt the initial trilinear diagram (obtained with specimens not exposed to high temperature) in order to numerically reproduce the fracture behaviour of PFRC affected by high temperature exposure.
The Anti-CGRP Antibody Fremanezumab Reduces Trigeminal Neurons Immunoreactive for CGRP and CGRP Receptor Components in Rat
Authors: Vogler Birgit , Kuhn Annette , Mackenzie Kimberly D. , Stratton Jennifer , Dux Mária , Messlinger Karl
Published: July 2023

Treatment with the anti-CGRP antibody fremanezumab is successful in the prevention of chronic migraine. In preclinical rat experiments, fremanezumab has been shown to reduce calcitonin gene-related peptide (CGRP) release from trigeminal tissues and the aversive behaviour to noxious facial stimuli, which are characteristic pathophysiological changes accompanying severe primary headaches. To further decipher the effects of fremanezumab underlying these antinociceptive effects in rats, immunohistochemistry and ELISA techniques were used to analyse the content and concentration of CGRP in the trigeminal ganglion as well as the ratio of trigeminal ganglion neurons immunoreactive to CGRP and CGRP receptor components 1-10 days after subcutaneous injection of fremanezumab (30 mg/kg) compared to an isotype control antibody. After fremanezumab treatment, the fraction of trigeminal ganglion neurons immunoreactive to CGRP and the CGRP receptor components calcitonin receptor-like receptor (CLR) and receptor activity modifying protein 1 (RAMP1) was significantly lowered compared to the control. The content and concentration of CGRP in trigeminal ganglia were not significantly changed. A long-lasting reduction of CGRP receptors expressed in trigeminal afferents may contribute to the attenuation of CGRP signalling and antinociceptive effects of monoclonal anti-CGRP antibodies in rats.
Research on Autonomous and Collaborative Deployment of Massive Mobile Base Stations in High-Rise Building Fire Field
Authors: Li Ke , Huang Chen , Liang JiaPing , Zou Yanbin , Xu Biao , Yao Yao , Zhang Yang , Liu Dandan
Published: July 2023

High-rise building fires pose a serious threat to the lives and property safety of the people. The lack of reliable and accurate positioning means is one of the main difficulties faced by rescue. In the absence of prior knowledge of the high-rise building fire environment, the coverage deployment of mobile base stations is a challenging problem that has not received much attention in the literature. This paper studies the problem of autonomous optimal deployment of base stations in high-rise building fire environment based on UAV group. A novel problem formulation is proposed that solves the non line of sight (NLOS) positioning problem in complex unknown environment. The purpose of this paper is to realize the coverage and deployment of mobile base stations in complex and unknown fire environment. The NLOS positioning problem in the fire field environment is turned into the line of sight (LOS) positioning problem through the optimization algorithm. And there are more than three LOS base stations nearby any point in the fire field. A control law which is formulated in a mathematically precise problem statement is developed that guarantees to meet mobile base stations deployment goal and to avoid collision. Finally, positioning accuracy of our method and that of common method were compared. The simulation result showed that the positioning accuracy of simulated firefighter in the fire field environment was improved greatly.