bluuebunny/crossref_metadata_2025 huggingface dataset:
Liaison traumatique: concepts, causes et mécanismes dans les relations intimes
Authors: Fonseca Nicole de Queiroz Lima , Oliveira Bruno Quintino de
Published: November 2021

Lorsque, après un incident violent, des liens émotionnels forts sont établis afin de connecter deux personnes, il y a l’installation d’un traumatisme appelé par la littérature comme un liaison traumatique. C’est une dépendance émotionnelle entre deux personnes, dans une relation caractérisée par des périodes d’abus, de violence et de déséquilibre de pouvoir, avec des liens de connexion intense, de distorsion cognitive et de stratégies comportementales des deux individus qui renforcent et maintiennent paradoxalement le lien, ce qui se reflète dans le cercle vicieux de la violence. Cependant, il y a un manque de littérature et de recherche scientifique sur le sujet au Brésil, ce qui souligne la nécessité d’une étude affinée et approfondie, car les causes et les effets du liaison traumatique ne sont pas encore exactement clairs, ce qui rend la compréhension et le traitement des individus, ainsi que leur rétablissement, un processus lent et douloureux. Ainsi, cette recherche est guidée par la question : qu’est-ce qu’un liaison traumatique et quels sont ses mécanismes ? Ainsi, il a été défini comme l’objectif général d’analyser le liaison traumatique dans les relations amoureuses, afin de donner naissance aux processus neuropsychobiologiques de traumatisme générés dans les relations intimes et d’étudier les raisons pour lesquelles les victimes restent dans des relations pathologiques, nous aborderons également le fonctionnement du syndrome de Stockholm et le stress post-traumatique chez les victimes d’abus dans les relations amoureuses en tant que facteurs générant un liaison traumatique. Pour la contextualisation, la problématisation et la validation du cadre théorique utilisé dans la recherche entreprise, la méthodologie utilisée était la revue de littérature ou la revue bibliographique, à partir de la lecture, de la sélection et de l’analyse de textes de différents genres, tels que des documents, des revues et des articles scientifiques liés au sujet et qui ont été publiés dans des revues et des journaux de la région. Il a été conclu que plusieurs facteurs émotionnels et neuropsychobiologiques sont la cause du liaison traumatique à établir au sein d’une relation.
Trauma Bonding: concepts, causes and mechanisms in intimate relationships
Authors: Fonseca Nicole de Queiroz Lima , Oliveira Bruno Quintino de
Published: November 2021

When, after a violent incident, strong emotional bonds are established in order to connect two people, there is the installation of a trauma called by the literature as trauma bonding. It is an emotional dependence between two people, in a relationship characterized by periods of abuse, violence and power imbalance, with bonds of intense connection, cognitive distortion and behavioral strategies of both individuals that paradoxically strengthen and maintain the bond, which is reflected in the vicious cycle of violence. However, there is a lack of literature and scientific research on the subject in Brazil, which highlights the need for a refined and in-depth study, since the causes and effects of trauma bonding are still not exactly clear, which makes the understanding and treatment of individuals, as well as their recovery, a slow and painful process. Thus, this research is guided by the question: what is trauma bonding and what are its mechanisms? Thus, it was defined as the general objective to analyze trauma bonding in loving relationships, in order to give birth to the neuropsychobiological processes of trauma generated in intimate relationships and to investigate the reasons why victims remain in pathological relationships, we will also address the functioning of Stockholm Syndrome and posttraumatic stress in victims of abuse in loving relationships as factors that generate trauma bonding. For contextualization, problematization and validation of the theoretical framework used in the research undertaken, the methodology used was the literature review or bibliographic review, from the reading, selection and analysis of texts of different genres, such as records, reviews and scientific articles related to the subject and which were published in journals and newspapers in the area. It was concluded that several emotional and neuropsychobiological factors are the cause for trauma bonding to be established within a relationship.
ОСОБЛИВОСТІ ОБЛІКУ РОЗРАХУНКІВ ЗА ПОДАТКАМИ В АГРАРНИХ ПІДПРИЄМСТВАХ
Authors: Чернецька Ольга , Міньковська Альона , Атамас Олександр
Published: November 2021

У статті проаналізовано особливості обліку розрахунків за податками в аграрних підприємствах. Наголошено на вимогах до інформаційного забезпечення господарських операцій в частині оподаткування, акцентовано увагу на важливості документального та облікового забезпечення розрахунків за податками в системі менеджменту аграрних підприємств. Розкрито сутність та особливості спрощеної системи оподаткування, наведено вимоги до суб’єктів господарювання в частині єдиного податку IV групи, зазначено ставки єдиного податку IV групи. Відображено порядок облікового забезпечення розрахунків за єдиним податком в аграрних підприємствах. Виокремлено особливості оподаткування податком на додану вартість, наведено ставки податку на додану вартість за окремими товарними позиціями сільськогосподарської продукції, акцентовано увагу на порядку складання податкової накладної, зазначено порядок облікового забезпечення розрахунків за податком на додану вартість.
УПРАВЛІНСЬКИЙ ОБЛІК ЯК СКЛАДОВА ПРИРОДНОГО ВИРОБНИЦТВА У ФЕРМЕРСЬКИХ ГОСПОДАРСТВАХ
Authors: Ткаченко Олександр , Саванчук Тетяна
Published: November 2021

Стаття присвячена вивченню управлінського обліку як складової природного виробництва у фермерських господарствах. Досліджено процес управління бізнесом, який складається із ряду етапів (планування, організація і мотивація, контроль, корегування) та елементів управлінського обліку (бюджети, розрахунки, прогнози; первинні документи обліку; облікові регістри; звіти про виконання). Доведено, що управлінський облік є складовою екологічного обліку в складі екологічного виробництва. Окреслені області екологічного управлінського обліку які зосереджена на удосконаленні системи розподілу витрат на охорону природного середовища, у тому числі вдосконалювання системи обліку, а також питань пов’язаних з інтернаціоналізацією зовнішніх (суспільних) витрат. Вивчені позитивні аспекти запровадження технологій природного виробництва у фермерських господарствах.
НЕРІВНІСТЬ СЕРЕД МІСЬКИХ ДІТЕЙ
Authors: Когатько Юрій , Полякова Світлана
Published: November 2021

Стаття присвячена актуальним питанням виявлення і дослідження особливостей нерівності міських сімей з дітьми, зокрема як монетарних, так і немонетарних аспектів. Проаналізовано бідність та фінансові можливості міських родин з дітьми, порівняно з аналогічними сім’ями в сільській місцевості. Показано, що в міських сім’ях з дітьми краща ситуація з бідністю, проте для дітей міст більш характерна немонетарна бідність і соціальне відчуження, які набувають проявів, що важко оцінити доступними статистичними даними. Визначено, що у великих містах найдужче загострюється питання наявності ресурсів у родин з дітьми, так як сучасне міське життя вимагає значних вкладень в дітей. Показано, що для дітей міст характерна підвищена небезпека потрапляння в несприятливу життєву ситуацію, так як в містах більша скупченість населення, і дітям частіше доводиться стикатися з соціальними хворобами і деструктивними субкультурами, які не завжди досягають сільської місцевості.
Dynamics and variability of POC burial in depocenters of the North Sea (Skagerrak), Cruise No. AL561, 2.08.2021 – 13.08.2021, Kiel – Kiel, APOC
Authors: Schmidt Mark
Published: November 2021

The AL561 cruise was conducted in the framework of the project APOC (“Anthropogenic impacts on Particulate Organic Carbon cycling in the North Sea”). This collaborative project between GEOMAR, AWI, HEREON, UHH, and BUND is to understand how particulate organic carbon (POC) cycling contributes to carbon sequestration in the North Sea and how this ecosystem service is compromised and interlinked with global change and a range of human pressures include fisheries (pelagic fisheries, bottom trawling), resource extraction (sand mining), sediment management (dredging and disposal of dredged sediments) and eutrophication. The main aim of the sampling activity during AL561 cruise was to recover undisturbed sediment from high accumulation sites in the Skagerrak/Kattegat and to subsample sediment/porewater at high resolution in order to investigate sedimentation transport processes, origin of sediment/POC and mineralization processes over the last 100- 200 years. Moreover, the actual processes of sedimentation and POC degradation in the water column and benthic layer will be addressed by sampling with CTD and Lander devices. In total 9 hydroacoustic surveys (59 profiles), 4 Gravity Corer, 7 Multicorer, 3 Lander and 4 CTD stations were successfully conducted during the AL561 cruise. - (Alkor-Berichte ; AL561)
Perbedaan Uji Efektivitas Ekstrak Buah Pepaya Dan Mentimun terhadap Bakteri Salmonella Thypi
Authors: Hermiaty Hermiaty , Karim Marzelina , Latief Shofiyah , Hidayati Prema H. , Ramadhani Suci
Published: November 2021

Salmonella typhi adalah bakteri penyebab demam tifoid. Penyakit ini menyerang hampir di semua negara, terutama di negara-negara berkembang seperti Indonesia. Penyakit demam tifoid ini dapat tertular lewat makanan atau minuman yang terkontaminasi oleh feses atau urin dari orang yang terinfeksi. Di Indonesia kloramfenikol masih merupakan obat pilihan utama untuk mengobati demam tifoid. Namun banyak dilaporkan adanya resistensi S. typhi terhadap antibiotik kloramfenikol.Oleh karena itu, mulai dikembangkan penelitian untuk meminimalisir efek samping dari penggunaan antibiotik. Salah satunya adalah dengan pengembangan antimikroba yang berasal dari bahan alam. Salah satu tanaman yang dapat dimanfaatkan sebagai obat tradisional adalah tanaman pepaya (Carica papaya L  memiliki nilai medis yang tinggi dan efek antibakteri . Adapun tanaman lain yang dapat di jadikan obat adalah mentimun (Cucumis sativus) dimana memiliki senyawa aktif yang berperan sebagai antifungi dan antibakteri. Mengetahui perbedaan daya antibakteri antara buah pepaya (Carica papaya L.) dan mentimun (Cucumis sativus L.)  terhadap bakteri Salmonella thypi. Jenis penelitian yang dilakukan adalah penelitian eksperimental labatorium dengan metode yang digunakan pada penelitian ini adalah metode disc diffution. Zona hambat yang dihasilkan oleh ekstrak buah pepaya pada dua replikasi yaitu rata-rata diameter sebesar 0 mm dan 7 mm dan zona hambat yang dihasilkan oleh ekstrak buah mentimun untuk dua replikasi yaitu rata-rata diameter sebesar 0 mm dan 16,7 mm. Ekstrak buah mentimun  dengan konsentrasi 100% lebih efektif karena memiliki daerah hambat yang lebih besar jika dibandingkan dengan ekstrak buah pepaya dengan konsentrasi 100%.
Isolasi dan Identifikasi Bakteri pada Mulut Sebelum dan Sesudah Wudhu
Authors: Fitriah Fitriah , Rachman Moch. Erwin , Gayatri Sri Wahyuni , Dwimartyono Fendy , Idrus Hasta Handayani
Published: November 2021

Rongga mulut merupakan gerbang masuknya berbagai macam mikroorganisme ke dalam tubuh dengan prevalensi penduduk yang mempunyai masalah gigi dan mulut di Indonesia mengalami peningkatan tiap tahunnya. Flora normal rongga mulut berperan sebagai pertahanan tubuh namun flora normal dapat menimbulkan penyakit, karena adanya faktor predisposisi yaitu kebersihan rongga mulut. Oleh karenanya perlu ditemukan alternatif dalam memelihara kesehatan mulut. Islam adalah agama yang menekankan kebersihan diri, misalnya berwudhu.. Penelitian ini bertujuan untuk mengetahui cara mengisolasi dan mengidentifikasi bakteri pada mulut sebelum dan sesudah wudhu. Penelitian ini menggunakan desain non eksperimental dengan metode Narrative Review . Penelusuran pustaka dilakukan melalui jurnal nasional, jurnal internasional, clinical key, textbook, dan proceding book tahun 2016 – 2020. Hasil penelitian ini didapatkan bahwa jenis bakteri yang terdapat dalam rongga mulut sebelum berwudhu adalah 33,33% Pseudomonas sp, 6,67% Lactobacillus sp, 3,33% Streptococcus sp, dan 0,14% Staphylococcus sp sedangkan jenis bakteri yang terdapat dalam rongga mulut setelah berwudhu adalah 26,8% Pseudomonas sp, 20% Lactobacillus sp, 5% Streptococcus sp, dan 2% Staphylococcus sp. Sehingga dapat disimpulkan bahwa terjadi perubahan jumlah bakteri yaitu peningkatan bakteri gram positif pada rongga mulut setelah berwudhu.
Hubungan Pola Makan Terhadap Status Gizi Anak Sekolah Dasar
Authors: Asmin Asmin , Arfah Arni Isnaini , Arifin Arina Fathiyyah , Safitri Asrini , Laddo Nirwana
Published: November 2021

Global Nutrition Report menunjukkan jumlah anak umur 5-19 tahun dengan prevalensi gizi lebih di Indonesia menunjukkan peningkatan. Analisis data Riskesdas 2018 di Jawa Timur prevalensi kurus dan sangat kurus 6,00% dan prevalensi gizi buruk dan gizi kurang 16,8% dan prevalensi gemuk 10,4%. Pola makan merupakan jumlah pangan yang dikonsumsi seseorang atau kelompok orang yang bertujuan untuk memenuhi kebutuhan fisiologi. Status gizi adalah keadaan yang diakibatkan oleh keseimbangan antara asupan zat gizi dari makanan dengan kebutuhan zat gizi yang diperlukan untuk metabolisme tubuh. Bertujuan untuk mengetahui hubungan pola makan terhadap status gizi anak sekolah dasar. Metode penelitian ini menggunakan literature review dengan desain narrative review yaitu mencari artikel yang membahas tentang hubunga pola makan terhadap status gizi anak yang telah dipublikasikan pada jurnal dari tahun 2017-2020. Jurnal dipilih berdasarkan kriteria inklusi dan eksklusi yang telah ditetapkan sebelumnya. Hasil penelitian berdasarkan telaah dari beberapa jurnal, didapatkan hasil pola makan baik sebesar 43% dan status gizi anak sekolah dasar termasuk dalam kategori baik sebesar 78,5% dan terdapat hubungan antara pola makan dengan status gizi pada anak usia sekolah dasar. Kesimpulan penelitian ini dari 5 jurnal penelitian dapat disimpulkan terdapat 3 jurnal yang menyatakan bahwa terdapat hubungan pola makan terhadap status gizi anak sekolah dasar.
Mixed-methods evaluation of the NHS Genomic Medicine Service for paediatric rare diseases: study protocol
Authors: Lewis Celine , Buchanan James , Clarke Angus , Clement Emma , Friedrich Bettina , Hastings-Ward Jillian , Hill Melissa , Horn Ruth , Lucassen Anneke M. , Patch Chris , Pickard Alexandra , Roberts Lauren , Sanderson Saskia C. , Wynn Sarah L. , Vindrola-Padros Cecilia , Lakhanpaul Monica
Published: November 2021

Background: A new nationally commissioned NHS England Genomic Medicine Service (GMS) was recently established to deliver genomic testing with equity of access for patients affected by rare diseases and cancer. The overarching aim of this research is to evaluate the implementation of the GMS during its early years, identify barriers and enablers to successful implementation, and provide recommendations for practice. The focus will be on the use of genomic testing for paediatric rare diseases.

Methods: This will be a four-year mixed-methods research programme using clinic observations, interviews and surveys. Study 1 consists of qualitative interviews with designers/implementers of the GMS in Year 1 of the research programme, along with documentary analysis to understand the intended outcomes for the Service. These will be revisited in Year 4 to compare intended outcomes with what happened in practice, and to identify barriers and facilitators that were encountered along the way. Study 2 consists of clinic observations (pre-test counselling and results disclosure) to examine the interaction between health professionals and parents, along with follow-up interviews with both after each observation. Study 3 consists of a longitudinal survey with parents at two timepoints (time of testing and 12 months post-results) along with follow-up interviews, to examine parent-reported experiences and outcomes. Study 4 consists of qualitative interviews and a cross-sectional survey with medical specialists to identify preparedness, facilitators and challenges to mainstreaming genomic testing. The use of theory-based and pre-specified constructs will help generalise the findings and enable integration across the various sub-studies.  

Dissemination: We will disseminate our results to policymakers as findings emerge, so any suggested changes to service provision can be considered in a timely manner. A workshop with key stakeholders will be held in Year 4 to develop and agree a set of recommendations for practice.
Interdisciplinarity
Authors: Thorén Henrik , Nagatsu Michiru , Schönach Paula
Published: November 2021

This chapter discusses the interdisciplinarity which lies at the heart of Sustainability Science. Drawing on the historical development of the field, this chapter offers examples of enquiry from multiple research centres.
AE Reporting and Causality
Authors: H Chen Wilbur , M Levine Myron
Published: November 2021

Adverse effects may be related, unrelated, or unknown in relation to a vaccine and may range from self-limited mild reactions to permanent sequelae.

The causal inference of any adverse effect to a vaccine is based on assessing the strength of association, temporal response, consistency and specificity of the association, and biological plausibility.

Safety evaluation depends on accurate reporting of adverse events during pre-licensure studies and post-licensure surveillance.
The Development of Problem Solving-Based Learning Modules on Economic Activity Materials for Class VII Students of Marsudi Siwi Catholic Junior High School
Authors: Wewu Teodorus Dangga , Fandyansari Melisa Wahyu
Published: November 2021

Modules are forms of teaching materials that are made in detail with standard language and understood by students, according to age and student learning abilities, so that the level of independent learning can be increased and followed by teacher guidance Responding to the lack of teaching materials, currently it is necessary to use learning models to improve students' learning abilities and can add insight or knowledge that is not boring for students. The right teaching materials in overcoming students' boredom include learning resources in the form of teaching materials. Problem Solving is a teaching and learning activity that scientifically students can think critically, and find solutions in solving a problem. The main purpose of this learning research is to investigate and solve a problem as well as master the learning objectives and be independent in teaching and learning activities in solving problems in learning activities. The type of research used in this research is development research with a Problem Solving approach. This research was conducted for two months starting from February 22, 2021 to April 22, 2021. Based on the results of the research, the results of the presentation of the module developed got a score of 93.47% from material experts and 83.92% from media experts. Based on the results of presentations from media experts and material experts, the developed module is feasible to use.
Feeding ecology and microbiome of the pteropod Limacina helicina antarctica
Authors: Thibodeau PS , Song B , Moreno CM , Steinberg DK
Published: November 2021

The pteropod (pelagic snail) Limacina helicina antarctica is a dominant grazer along the Western Antarctic Peninsula (WAP) and plays an important role in regional food web dynamics and biogeochemical cycling. For the first time, we examined the gut microbiome and feeding ecology of L. h. antarctica based on 16S and 18S rRNA gene sequences of gut contents in the WAP during austral summer. Eukaryotic gut contents of L. h. antarctica indicate that this species predominantly feeds on diatoms and dinoflagellates, supplementing its diet with ciliates and foraminifera. Mollicutes bacteria were a consistent component of the gut microbiome. Determining the gut microbiome and feeding ecology of L. h. antarctica aids in identifying the underlying mechanisms controlling pteropod abundance and distribution in a region of rapid environmental change.
Efecto de la suplementación con forrajes arbustivos sobre el desempeño productivo de conejos (Oryctolagus cuniculus)
Authors: Calderon-Bedoya Veronica Marcela , Castaño-Benitez Miguel Angel , Velásquez-Vélez Raul Adolfo
Published: November 2021

Actualmente existe una alta demanda de alimentos balanceados destinados a la ceba de animales que resultan costosos, por lo tanto, los alimentos balanceados no convencionales son una alternativa para obtener buenos resultados a bajo costo; planteando como objetivo evaluar el efecto de la suplementación de diferentes forrajes en el desempeño productivo y rendimiento de la canal de 24 conejos machos raza Nueva Zelanda, distribuidos en 4 tratamientos con 6 individuos cada uno, determinando ganancia de peso, rendimiento de canal y costos de alimentación. Se realizó un análisis de medidas repetidas en el tiempo con el paquete estadístico SAS, encontrando que no hay diferencias significativas (p≤0,05) entre el Botón de oro y el alimento comercial, con respecto a peso final y rendimiento de la canal, identificando una disminución en costos, concluyendo que la suplementación con materias primas no convencionales es una alternativa para reducir los costos de producción, hasta un 59%.

Currently there is a high demand for balanced feeds intended for fattening animals that are expensive, therefore, unconventional balanced feeds are an alternative to obtain good results at low cost, consequently, the objective was to evaluate the effect of supplementation of different forages in the productive and carcass performance of 24 male New Zealand breed rabbits, distributed in 4 treatments with 6 individuals each one, measuring weight gain, carcass weight and feeding costs. It performed a repeated measures analysis over time with the SAS statistical package, there are no significant differences (p≤0,05) between Mexican sunflower and commercial feed, with respect to carcass performance, identifying a decrease in costs, concluding that supplementation with unconventional raw materials is an alternative to reduce production costs, up to 21,3%.
Population, Aquaculture and Transplantation Applications of Critically Endangered Species Pinna nobilis (Linnaeus 1758) in the Mediterranean Sea
Authors: ACARLI Sefa
Published: November 2021

The population of fan mussel, Pinna nobilis across the Mediterranean Sea has been affected by factors such as overfishing, fisheries processes, environmental pollution, destruction of habitat, tourism, etc. Therefore, the species P. nobilis was taken under protection by the Decisions of the Council of Europe and Barcelona Convention. However, its mortality rates of 100% have been reported to be due to Haplosporidium pinnae, a parasite in different Mediterranean regions. The status of P. nobilis has thus been revised to be reduced from “Vulnerable” to “Critically Endangered” and the importance of all the studies on the species further increased. The aim of the study is to present the current status of P. nobilis, the native to the Mediterranean, by combining the relevant studies on ecology, aquacultural process (larvae, spat settlement and rearing), culture methods and transplantation. The present study has provided comprehensive knowledge on the current status P. nobilis population, aquaculture and transplantation activities. Except for studies to determine stocks, in particular, those on collecting young individuals from nature and planting and growing them in predetermined sites as well as their production through various cultures from their larval phase onwards are of great importance in terms of rehabilitation and sustenance of the damaged P. nobilis population. Therefore, alternative and potential habitats should be created thanks to transplantation and aquaculture. Marine protected areas should be determined to enable a healthy P. nobilis population to be sustained.
GIS PROJECT AS AN UNIFIED SPACE FOR WORKING WITH GEOLOGICAL AND GEOPHYSICAL DATA
Authors: Loginov Dmitriy S.
Published: November 2021

The article described the role of GIS projects when working with geological and geophysical data in the production process of oil and gas enterprises. The sequence of the formation of GIS project content in the process of geological exploration is highlighted. Practical examples of using of accumulated geodata are given. They used for assessing the quality of initial geophysical data, for studying the geological structure of the area of interest, for preparing cartographic materials of various degrees of significance. The approbation was carried out within the cartographic support for geological exploration works at sites in various regions of the Russian Federation and other world countries. The universality of GIS projects using has been determined: as a tool for working with geodata, an instrument for creating cartographic products, a single point of access to the accumulated information, a data warehouse. The general patterns of consumers' requests for digital cartographic information frequency changes during the main stages of geophysical work have been identified.
TO THE QUESTION OF REGULATORY AND LEGAL SUPPORT FOR THE CREATION AND MAINTENANCE OF A THREE-DIMENSIONAL REAL ESTATE CADASTRE IN RUSSIA
Authors: Giniyatov Artur I.
Published: November 2021

The paper discusses some issues that may arise in the formation of the regulatory framework for the creation and maintenance of a three-dimensional real estate cadastre in Russia. An analytical review of the prerequisites for the creation of a three-dimensional real estate cadastre in Russia has been carried out. The priorities of interaction between urban planning and cadastral activities are considered, as well as the definition of scientifically grounded requirements for the accuracy of cadastral work, taking into account the introduction of the third, high-altitude coordinate H. Close attention is paid to the expansion of the requirements for the technical plan, in the transition to a 3D cadastre, the general availability of information about real estate objects on the public cadastral map.
OVERVIEW OF REGULATORY AND LEGAL SUPPORT FOR FORMING A BARRIER-FREE ENVIRONMENT IN REAL ESTATE
Authors: Demidenko Anastasia Y. , Dubrovsky Alexey V.
Published: November 2021

The article analyzes the regulatory framework for the formation of a barrier-free environment "accessible environment" in real estate in the Russian Federation. Planning, design and construction of real estate objects is based on regulatory legal acts, regulatory and technical documents, as well as other approved acts of legislative bodies. Formation of a barrier-free environment implies an integrated approach at all stages. The first step is the regulatory framework. In the course of the work, a base of normative knowledge was formed for the formation of an "accessible environment" for people with limited mobility.
Afet Lojistiği, Afet Lojistiği Performansı ve Afete Müdahale Performansı Ölçek Çalışması
Authors: Küçük Orhan
Published: November 2021

Toplumun tamamı veya belli kesimleri için fiziksel, ekonomik ve sosyal kayıplar doğuran, normal hayatı ve insan faaliyetlerini durduran veya kesintiye uğratan, etkilenen toplumun baş etme kapasitesinin yeterli olmadığı doğal, teknolojik veya insan kaynaklı olaylar afet olarak tanımlanmaktadır.
Afet lojistiği; İnsanların baş edemeyecekleri şekilde hayatın işleyişine zarar veren olaylara (Afet) muhatap olanlara yapılacak müdahalelerde, ulaşım, konaklama, ihtiyaç malzemelerinin stoklanması ve dağıtımı ile afetzedelerin hastane ve başka yerleşim yerlerine götürülmeleri, yaşama aktivitelerine devam edebilmelerine ilişkin uygulamaların, bilgi paylaşımı ile birlikte planlı ve koordineli bir biçimde gerçekleştirilmesidir.
Afete müdahalenin başarılı olabilmesi ve bunun karşılaştırmalı olarak değerlendirilebilmesi bakımından, afet lojistiği performansı ve afete müdahale performans faktörlerinin önem düzeyinin belirlenmesi önem arz etmektedir.
Bu konuda da yazar tarafından geliştirilmiş ölçekler sahada test edilmiş ve bilimsel araştırmalarda kullanılabileceği ispat edilmiştir. Likert biçiminde hazırlanmış olan ölçeğe ilişkin veri toplama aracı bu çalışmada değerlendirilerek paylaşılmıştır.
Rancang Bangun Turbin Crossflow Pada Spiral Vortex Turbine House Sebagai Pembangkit Listrik Tenaga Pikohidro
Authors: Sigit Setya Wiwaha  , Ronilaya Ferdian , Dali Sri Wahyuni , Ulhaq Farhan Dhiya , Fariz Muhfid M. Naufal , Setyawan Ricky
Published: November 2021

Javan Langur Center merupakan pusat rehabilitasi lutung jawa yang berada di tengah hutan Coban Talun. Di kawasan tersebut terdapat sungai yang bisa dijadikan sebagai Pembangkit Listrik Tenaga Pikohidro dengan turbin crossflow sebagai komponen utamanya. Pemilihan turbin crossflow bertujuan untuk menganalisis desain terbaru dari turbin crossflow, mengetahui pengaruh jumlah sudu terhadap kecepatan putaran turbin pada sistem PLTPH dan pengaturan debit untuk mendapatkan keluaran yang maksimal. Penelitian diawali dari pembuatan desain secara 2D kemudian dilanjutkan secara 3D dan aplikasikan dalam bentuk nyata. Pengumpulan data dilakukan dengan membuat alur kerja keseluruhan proses dengan metode analisis menggunakan perbandingan data pengujian dan pengukuran di lapangan. Setelah pengambilan data dan analisis turbin pada bukaan intake 100% menghasilkan kecepatan turbin sebesar 52 rpm tanpa puli dan menghasilkan keluaran 18 volt dengan arus 0,31 A ketika terhubung ke baterai.
Mapping our way out? Critical reflections on historical research and the Faure report
Authors: Hake Barry
Published: November 2021

Contributions to the literature have postulated an historical shift in policy narratives from the Faure report’s formulation of “lifelong education” for UNESCO in 1972 to a focus on “lifelong learning” since the mid-1990s. It has also been argued that the policy narrative articulated by de-schoolers in the early 1970s was incorporated in the Faure report. This paper critically examines the empirical foundations for such arguments and is based on a re-reading of the policy repertoire articulated by Faure’s report together with an analysis of the de-schoolers’ reception of the report in the early 1970s. Based upon a re-reading of primary texts and secondary sources from the 1970s, the analysis demonstrates that these widely accepted arguments constitute a problematic interpretation of the historical relationships between the key policy narratives in the 1970s. The conclusions identify a number of significant areas for further empirical research regarding the historical relationships between first generation policy narratives.
Dynamic Pathfinding for a Swarm Intelligence Based UAV Control Model Using Particle Swarm Optimisation
Authors: Pyke Lewis M. , Stark Craig R.
Published: November 2021

In recent years unmanned aerial vehicles (UAVs) have become smaller, cheaper, and more efficient, enabling the use of multiple autonomous drones where previously a single, human-operated drone would have been used. This likely includes crisis response and search and rescue missions. These systems will need a method of navigating unknown and dynamic environments. Typically, this would require an incremental heuristic search algorithm, however, these algorithms become increasingly computationally and memory intensive as the environment size increases. This paper used two different Swarm Intelligence (SI) algorithms: Particle Swarm Optimisation and Reynolds flocking to propose an overall system for controlling and navigating groups of autonomous drones through unknown and dynamic environments. This paper proposes Particle Swarm Optimisation Pathfinding (PSOP): a dynamic, cooperative algorithm; and, Drone Flock Control (DFC): a modular model for controlling systems of agents, in 3D environments, such that collisions are minimised. Using the Unity game engine, a real-time application, simulation environment, and data collection apparatus were developed and the performances of DFC-controlled drones—navigating with either the PSOP algorithm or a D* Lite implementation—were compared. The simulations do not consider UAV dynamics. The drones were tasked with navigating to a given target position in environments of varying size and quantitative data on pathfinding performance, computational and memory performance, and usability were collected. Using this data, the advantages of PSO-based pathfinding were demonstrated. PSOP was shown to be more memory efficient, more successful in the creation of high quality, accurate paths, more usable and as computationally efficient as a typical incremental heuristic search algorithm when used as part of a SI-based drone control model. This study demonstrated the capabilities of SI approaches as a means of controlling multi-agent UAV systems in a simple simulation environment. Future research may look to apply the DFC model, with the PSOP algorithm, to more advanced simulations which considered environment factors like atmospheric pressure and turbulence, or to real-world UAVs in a controlled environment.
The Simulation of Muscles Forces Increases the Stresses in Lumbar Fixation Implants with Respect to Pure Moment Loading
Authors: Panico Matteo , Bassani Tito , Villa Tomaso Maria Tobia , Galbusera Fabio
Published: November 2021

Simplified loading conditions such as pure moments are frequently used to compare different instrumentation techniques to treat spine disorders. The purpose of this study was to determine if the use of realistic loading conditions such as muscle forces can alter the stresses in the implants with respect to pure moment loading. A musculoskeletal model and a finite element model sharing the same anatomy were built and validated against in vitro data, and coupled in order to drive the finite element model with muscle forces calculated by the musculoskeletal one for a prescribed motion. Intact conditions as well as a L1-L5 posterior fixation with pedicle screws and rods were simulated in flexion-extension and lateral bending. The hardware stresses calculated with the finite element model with instrumentation under simplified and realistic loading conditions were compared. The ROM under simplified loading conditions showed good agreement with in vitro data. As expected, the ROMs between the two types of loading conditions showed relatively small differences. Realistic loading conditions increased the stresses in the pedicle screws and in the posterior rods with respect to simplified loading conditions; an increase of hardware stresses up to 40 MPa in extension for the posterior rods and 57 MPa in flexion for the pedicle screws were observed with respect to simplified loading conditions. This conclusion can be critical for the literature since it means that previous models which used pure moments may have underestimated the stresses in the implants in flexion-extension and in lateral bending.
Hydrogel-Based Biomaterials Engineered from Natural-Derived Polysaccharides and Proteins for Hemostasis and Wound Healing
Authors: Cheng Junyao , Liu Jianheng , Li Ming , Liu Zhongyang , Wang Xing , Zhang Licheng , Wang Zheng
Published: November 2021

Rapid and effective hemostasis is of great importance to improve the quality of treatment and save lives in emergency, surgical practice, civilian, and military settings. Traditional hemostatic materials such as tourniquets, gauze, bandages, and sponges have shown limited efficacy in the management of uncontrollable bleeding, resulting in widespread interest in the development of novel hemostatic materials and techniques. Benefiting from biocompatibility, degradability, injectability, tunable mechanical properties, and potential abilities to promote coagulation, wound healing, and anti-infection, hydrogel-based biomaterials, especially those on the basis of natural polysaccharides and proteins, have been increasingly explored in preclinical studies over the past few years. Despite the exciting research progress and initial commercial development of several hemostatic hydrogels, there is still a significant distance from the desired hemostatic effect applicable to clinical treatment. In this review, after elucidating the process of biological hemostasis, the latest progress of hydrogel biomaterials engineered from natural polysaccharides and proteins for hemostasis is discussed on the basis of comprehensive literature review. We have focused on the preparation strategies, physicochemical properties, hemostatic and wound-healing abilities of these novel biomaterials, and highlighted the challenges that needed to be addressed to achieve the transformation of laboratory research into clinical practice, and finally presented future research directions in this area.
Immobilization of Glycogen Synthase Kinase-3β Inhibitor on 316L Stainless Steel via Polydopamine to Accelerate Endothelialization
Authors: Zhang Ming , Shi Xudong , Sun Hai , Xu Donghua , Gao Yang , Wu Xi , Zhang Jianqi , Zhang Jichang
Published: November 2021

The coverage of stents with healthy endothelium is crucial to the success of cardiovascular stent implantation. Immobilizing bioactive molecules on stents is an effective strategy to generate such stents. Glycogen synthase kinase-3β inhibitor (GSKi) is a bioactive molecule that can effectively accelerate vascular endothelialization. In this work, GSKi was covalently conjugated on 316L stainless steel through polydopamine to develop a stable bioactive surface. Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM) and water contact angle results revealed the successful introduction of GSKi onto 316L stainless steel. The GSKi coating did not obviously affect the hemocompatibility of plates. The adhesion and proliferation of human coronary artery endothelial cells (HCAECs) on stainless steel was significantly promoted by the addition of GSKi. In summary, this work provides a universal and stable strategy of immobilizing GSKi on the stent surface. This method has the potential for widespread application in the modification of vascular stents.
Oligomerization of Mutant p53 R273H is not Required for Gain-of-Function Chromatin Associated Activities
Authors: Annor George K. , Elshabassy Nour , Lundine Devon , Conde Don-Gerard , Xiao Gu , Ellison Viola , Bargonetti Jill
Published: November 2021

The TP53 gene is often mutated in cancer, with missense mutations found in the central DNA binding domain, and less often in the C-terminal oligomerization domain (OD). These types of mutations are found in patients with the rare inherited cancer predisposition disorder called Li-Fraumeni syndrome. We previously found that mutant p53 (mtp53) R273H associates with replicating DNA and promotes the chromatin association of replication-associated proteins mini-chromosome maintenance 2 (MCM2), and poly ADP-ribose polymerase 1(PARP1). Herein, we created dual mutants in order to test if the oligomerization state of mtp53 R273H played a role in chromatin binding oncogenic gain-of-function (GOF) activities. We used site-directed mutagenesis to introduce point mutations in the OD in wild-type p53 (wtp53), and mtp53 R273H expressing plasmids. The glutaraldehyde crosslinking assay revealed that both wtp53 and mtp53 R273H formed predominantly tetramers, while the single OD mutant A347D, and the dual mtp53 R273H-A347D, formed predominantly dimers. The R337C, L344P, mtp53 R273H-R337C, and mtp53 R273H-L344P proteins formed predominantly monomers. Wtp53 was able to activate the cyclin-dependent kinase gene p21/waf and the p53 feedback regulator MDM2. As expected, the transactivation activity was lost for all the single mutants, as well as the mtp53 R273H-dual mutants. Importantly, mtp53 R273H and the dual oligomerization mutants, R273H-A347D, R273H-R337C, and R273H-L344P were able to interact with chromatin. Additionally, the dual oligomerization mutants, R273H-A347D, R273H-R337C, and R273H-L344P, maintained strong interactions with MCM2 and PARP1. Our findings suggest that while mtp53 R273H can form tetramers, tetramer formation is not required for the GOF associated chromatin interactions.
The Redox Homeostasis of Skeletal Muscle Cells Regulates Stage Differentiation of Toxoplasma gondii
Authors: Rahman Md. Taibur , Swierzy Izabela J. , Downie Bryan , Salinas Gabriela , Blume Martin , McConville Malcolm J. , Lüder Carsten G. K.
Published: November 2021

Toxoplasma gondii is an obligatory intracellular parasite that causes persistent infections in birds and mammals including ~30% of the world’s human population. Differentiation from proliferative and metabolically active tachyzoites to largely dormant bradyzoites initiates the chronic phase of infection and occurs predominantly in brain and muscle tissues. Here we used murine skeletal muscle cells (SkMCs) to decipher host cellular factors that favor T. gondii bradyzoite formation in terminally differentiated and syncytial myotubes, but not in proliferating myoblast precursors. Genome-wide transcriptome analyses of T. gondii-infected SkMCs and non-infected controls identified ~6,500 genes which were differentially expressed (DEGs) in myotubes compared to myoblasts, largely irrespective of infection. On the other hand, genes related to central carbohydrate metabolism, to redox homeostasis, and to the Nrf2-dependent stress response pathway were enriched in both infected myoblast precursors and myotubes. Stable isotope-resolved metabolite profiling indicated increased fluxes into the oxidative branch of the pentose phosphate pathway (OxPPP) in infected myoblasts and into the TCA cycle in infected myotubes. High OxPPP activity in infected myoblasts was associated with increased NADPH/NADP+ ratio while myotubes exhibited higher ROS levels and lower expression of anti-oxidants and detoxification enzymes. Pharmacological reduction of ROS levels in SkMCs inhibited bradyzoite differentiation, while increased ROS induced bradyzoite formation. Thus, we identified a novel host cell-dependent mechanism that triggers stage conversion of T. gondii into persistent tissue cysts in its natural host cell type.
Non-invasive Systemic Hemodynamic Index in Vascular Risk Stratification Tailored for Hypertensives
Authors: Zhang Jianning , Liang Jiawen , Zhang Xiaoyu , Su Chen , He Jiang , Qiu Yumin , Zhou Zhe , Wang Zhichao , Dong Bing , Tu Qiang , Xu Shiyue , Xia Wenhao , Tao Jun
Published: November 2021

Vascular dysfunction is a key hallmark of hypertension and related cardiovascular outcomes. As a well-known hemodynamic disease, hypertension is characterized by abnormal ventricular-vascular interactions. Complementing non-invasive systemic hemodynamics in hypertensive vascular risk assessment is of promising significance. We aimed to investigate the effects of abnormal hemodynamic states other than elevated blood pressure on vascular damage and establish a united index of systemic hemodynamics for generalized vascular risk evaluation. Non-invasive systemic hemodynamics, assessed by impedance cardiography, was compared among blood pressure stages. Vascular function was evaluated by flow-mediated dilation (FMD) and brachial-ankle pulse wave velocity (baPWV). Systemic hemodynamics was obtained from a total of 88 enrollees with a mean (±SD) systolic blood pressure 140 (±17) mm Hg, and aged 17 to 91 years. Both stroke systemic vascular resistance index and left stroke work index exhibited a significant alteration among blood pressure stages (p < 0.001; p = 0.01, respectively), whereas heterogeneous hemodynamic and vascular function subsets existed within similar blood pressure. In addition, blood pressure categories failed to recognize between-group differences in endothelial dysfunction (p = 0.88) and arterial stiffness (p = 0.26). An increase in myocardial contractility and a parallel decrease in afterload was associated with the decline of vascular dysfunction. Systemic Hemodynamic Index (SHI), as a surrogate marker, demonstrated a significantly negative correlation with vascular damage index (VDI, r = −0.49, p < 0.001). These findings illustrate that systemic hemodynamics underlying hypertensives provides more vascular information. The SHI/VDI score may be a feasible tool for cardiovascular function assessment.
Clinical Significance of Intermediate-Density Lipoprotein Cholesterol Determination as a Predictor for Coronary Heart Disease Risk in Middle-Aged Men
Authors: Yoshida Hiroshi , Ito Kumie , Manita Daisuke , Sato Ryo , Hiraishi Chika , Matsui Sadako , Hirowatari Yuji
Published: November 2021

Background: Not only low-density lipoprotein (LDL) cholesterol but also non-high-density lipoprotein cholesterol (non-HDL-C), very low-density lipoprotein (VLDL) cholesterol (VLDL-C), and intermediate-density lipoprotein (IDL) cholesterol (IDL-C) are reported to be significant risk markers for coronary heart disease (CHD). We reported the relevance of IDL-C to Framingham risk score (F-score), but the present study addressed the relevance of IDL-C to Suita score (S-score), a risk score for coronary heart disease (CHD) developed for the Japanese individuals in addition to F-score.

Methods: The cholesterol levels of lipoproteins, including triglyceride (TG)-rich lipoproteins (IDL and VLDL), were measured by an anion exchange high-performance liquid chromatography (AEX-HPLC). This study enrolled 476 men, aged mean 51 years and free of CHD and stroke.

Results: Non-HDL-C, IDL-C, and VLDL-C significantly correlated with F-score and S-score. In the multiple stepwise regression analysis, IDL-C as well as body mass index (BMI) significantly correlated with both F-score and S-score in both the total subjects and the subjects without drug therapy. The multivariate logistic analysis with the model composed of BMI and IDL-C as the predictor variables demonstrated that 1 SD increase in IDL-C was an independent predictor for 10-year CHD risk >10% of F-score (OR 1.534, 95% CI 1.266–1.859, p < 0001) and that of S-score (OR 1.372, 95% CI 1.130–1.667, p = 0.0014) in the total subjects. Even in the subjects without the drug therapy, the increased IDL-C, as well as BMI, were significant predictors for 10-year CHD risk >10% of S-score as well as F-score.

Conclusion: These results suggest the significant relevance of the increased IDL-C for CHD risk scores in middle-aged men free of CHD and stroke. Further investigations are needed in women and elderly subjects.