bluuebunny/crossref_metadata_2025 huggingface dataset:
Pottery evolution pattern discovery based on deep learning: case study of Miaozigou culture in China
Authors: Pang Honglin , Qi Xiujin , Xiao Chengjun , Xu Ziying , Ding Guangchen , Chang Yi , Yang Xi , Duan Tianjing
Published: October 2024

Potteries, one of the tools widely used by early humans, encapsulates rich historical information. Deep neural networks have been applied to analyzing pottery digital images, bypassing the need for intricate handcrafted features. However, existing models focus solely on pottery shape comparison, neglecting the analysis of their evolution across different historical periods. In this work, we propose a method based on deep learning to assist experts in identifying the evolutionary patterns of a given pottery type within their specified chronological divisions. First we train a convolutional neural network for pottery classification, extracting low and high level features that represent different ages of pottery samples. Next, we employ clustering algorithms to identify representative potteries for each historical period based on high level features. To facilitate intuitive comparisons across different ages, we use shallow features and compute cosine similarities between potteries, visualizing shape and decoration differences. This approach enhances understanding of pottery evolution patterns directly through visual analysis. The effectiveness and efficiency of our proposed method are evaluated by validating it on three distinct era division cases using data from the Dabagou and Miaozigou archaeological sites, which represent the Miaozigou culture and exhibit clear evolutionary patterns. Our method identifies representative artifacts for each era and uncovers their evolutionary patterns effectively and efficiently, achieving conclusions comparable to those of experts while significantly reducing time compared to traditional manual methods.
Management of gastroschisis in an extremely low birth weight infant: report of a case
Authors: Oyachi Noboru , Numano Fuminori , Shinohara Tamao , Murakami Yasushi , Nemoto Atsushi , Naito Atsushi
Published: October 2024

Background

Gastroschisis is a rare congenital anomaly in which abdominal organs herniate through a defect in the abdominal wall. Managing gastroschisis in extremely low birth weight (ELBW) infants presents significant challenges because of their immature physiologies and increased risk of complications.

Case presentation: This report discusses the case of a female ELBW infant born via an emergency cesarean section at 29 weeks of gestation, weighing 768 g, who had a prenatal diagnosis of gastroschisis. Postnatal management included immediate surgical intervention using a hand-made silo manufactured from expanded polytetrafluoroethylene (ePTFE) sheets that were sutured to the patient’s abdominal wall to accommodate her small abdominal cavity and preserve mesenteric blood flow. Necrotizing enterocolitis with bowel perforation emerged as a complication, which led to the excision of a 10 cm segment of the ileum and the creation of an ileostomy. The infant experienced insufficient weight gain and liver dysfunction. However, she was eventually discharged on day 142 of life, weighing 2774 g, on oral feeding, without significant complications.

Conclusions

This case emphasizes how prematurity significantly affected the patient’s clinical outcomes, and highlights the importance of individualized management strategies. Our experience demonstrates that custom silo placement allows for the size to be adapted to the abdominal defect, and highlights the critical need to prioritize postnatal bowel perfusion in ELBW infants with gastroschisis.
Disabling foot pain and its impact on daily living among people with psoriatic arthritis in Singapore: a cross-sectional observational investigation
Authors: Teo Vanessa H. Y. , Chia Kai Li , Bowen Catherine , Lahiri Manjari , Cheung Peter P. M. , Turner Deborah E. , Carter Kate
Published: October 2024

Background

Psoriatic Arthritis (PsA)-related foot involvement has been shown to have a profound impact on daily functioning, with most studies having focused on predominantly Caucasian populations. The aim was to describe disabling foot pain (DFP) and its impact on daily living in PsA in Singapore.

Methods

A cross-sectional, retrospective study was conducted using clinical data collected during a single-visit to a rheumatology clinic in Singapore. Records for adults with physician-diagnosed PsA were reviewed for sociodemographic information, disease characteristics, global disease activity and burden. Foot-specific measures included clinical assessment and the Manchester Foot Pain and Disability Index used to define DFP and evaluate between-group differences.

Results

Forty-two participants with PsA (83% female, 57% Chinese, 31% Malay, 9.5% Indian, mean (SD) age 54-years (16)) attended the rheumatology clinic over the study-period. The median (IQR) disease duration was 2-years (11) and all were taking current DMARDs. Global disease measures demonstrated mild-to-moderate global disease activity and mild functional impairment, and were significantly higher in those with DFP. Despite 90% reporting to be coping well with their condition, self-care and having emotional support (n = 38), this study sample demonstrated high levels of anxiety/depression (29%), sleep disturbance (34%) and fatigue (24%), and a lack of disease- and drug-specific knowledge (64%). Further management was indicated for medication adherence counselling (48%), occupational therapy (43%), physiotherapy (36%) and podiatry (30%). Nearly half had current foot pain with 40% reporting DFP (n = 17), which caused significantly greater difficulty walking 3 km than those without DFP (p < 0.05). Rearfoot enthesitis (plantar fasciitis, Achilles enthesitis) was the most common cause of DFP (67%) with pain lasting longer than 1-year. 72% were overweight or obese, with a high proportion not engaging in any cardiovascular exercise (70%). Three of 42 participants had previously seen a podiatrist.

Conclusions

People with DFP in PsA experience more severe global disease activity, reduced mobility and higher levels of negative impact on their daily lives in Singapore. In the absence of working in a multidisciplinary-team, there is value in comprehensive assessments that have potential to capture a holistic view of personal impact and improve person-centred care in PsA.
Outcome of tailored antiplatelet therapy in carotid stenting: a retrospective comparative study
Authors: Vigláš Pavol , Smolka Vojtěch , Raupach Jan , Hejčl Aleš , Černík David , Cihlář Filip
Published: October 2024

Background

Carotid stenting requires dual antiplatelet therapy to effectively prevent thromboembolic complications. However, resistance to clopidogrel, a key component of this therapy, may lead to persistent risk of these complications. The aim of this study was to determine, if the implementation of routine platelet function testing and adjusting therapy was associated with lower incidence of thromboembolic complications and death.

Methods

All consecutive patients treated with carotid artery stenting in a single institution over 8 years were enlisted in a retrospective study. Platelet function testing was performed, and efficient antiplatelet therapy was set before the procedure. Incidence of procedure-related stroke or death within periprocedural period (0–30 days) was assessed. The results were evaluated in relation to the findings of six prominent randomized control trials.

Results

A total of 241 patients were treated for carotid stenosis, seven patients undergo CAS on both sides over time. There was 138 symptomatic (55,6%) and 110 asymptomatic stenoses (44,4%). Five thromboembolic complications (2,01%) occurred, four of them (1,61%) was procedure-related. Two patients died because of procedure-related stroke (0,82%). Incidence of procedure-related stroke or death was significant lower compared to the results of CREST study (2,01% vs. 4,81%, P = 0,0243) in the entire cohorts, and to the results of ICSS study in the symptomatic cohorts (2,86% vs. 7,37%, P = 0,0243), respectively.

Conclusions

Tailored antiplatelet therapy in carotid stenting is safe and seems to be related with lower incidence of procedure-related death or stroke rate. Larger prospective studies to assess whether platelet function testing-guided antiplatelet therapy is superior to standard dual antiplatelet should be considered.
Intergenerational Testimonials and the Politics of Black Cherokee Belonging
Authors: Eure Eve
Published: October 2024

This article extends Tiya Miles’s study on the Black Cherokee Shoe Boots family by reading the legal documents they submitted to the Cherokee Nation—citizenship applications and land deeds as intergenerational testimonials. These documents, the article argues, constitute intergenerational testimonials because they record how the Shoe Boots family produced their own archive, their own print record across time and for future generations, as one strategy to build a livable world within and on Cherokee lands. As intergenerational testimonials, they transmit histories of unfinished familial claims and materially contain the fragmentary echoes of a collective set of desires. These testimonials refuse a racial and colonial conception of belonging. The article argues that the collaborative political labor of submitting claims captures the plurality of expression in the documents. What appears as an individual claim, the article contends, is instead linked to a network of familial ties. Put another way, the article reads the use of “I” in a family member’s citizenship application, for example, as constituting a collective utterance that embeds the desires of family members, whether living, lost, or dead.
Εισαγωγή μεθόδων ολικής ποιότητας στο δημόσιο τομέα μέσω της επίτευξης διοικητικών στόχων
Authors: Τσανάκας Ζήκος
Published: October 2024

Η παρούσα διατριβή προτείνει ένα πλαίσιο για τη διασφάλιση της ποιότητας των διοικητικών υπηρεσιών των ΑΕΙ μέσα στο οποίο οφείλουν να λειτουργούν. Το πλαίσιο αυτό έχει ως σκοπό τη βελτίωση, την ενίσχυση και την αποτελεσματικότητα των διοικητικών υπηρεσιών και ταυτόχρονα της εκπαιδευτικής διαδικασίας, καθώς οι διοικητικές υπηρεσίες αποτελούν αρωγό για τους φοιτητές, ώστε ανεμπόδιστα να ασχοληθούν με το κοπιώδες λειτούργημα τους, δηλαδή τα μαθήματα και την έρευνα. Οι περισσότερες έρευνες και μελέτες επικεντρώνονται στην αξιολόγηση των προγραμμάτων σπουδών και του διδακτικού προσωπικού. Όμως, δεν αρκεί να αξιολογούνται μόνο τα προγράμματα σπουδών και το διδακτικό προσωπικό αλλά οφείλει να υφίσταται αξιολόγηση σε όλα τα επίπεδα και μάλιστα στη διοικητική υποστήριξη. Κύριο ρόλο στη διαμόρφωση αυτού του πλαισίου διαδραματίζει η υιοθέτηση από τις διοικητικές υπηρεσίες των μεθόδων της Διοίκησης Ολικής Ποιότητας που βοηθά στη συλλογή ποιοτικών δεδομένων. Για τη διαμόρφωση του πλαισίου χρησιμοποιήθηκαν πηγές από τη διεθνή και την ελληνική βιβλιογραφία, μελέτες και εργασίες ειδικών, ετήσιες εκθέσεις αξιολόγησης της ΑΔΙΠ, διαδικασίες αξιολόγησης των ΑΕΙ (προσαρμογή των διεθνών πρακτικών στα ελληνικά δεδομένα), στατιστικά στοιχεία μελετών αλλά και συνεντεύξεις με μέλη της ακαδημαϊκής κοινότητας (μέλη ΜΟΔΙΠ, ΚΕΦΟΙ, φοιτητές). Η διασφάλιση της ποιότητας αποτελεί ένα εργαλείο που θα πρέπει να αποτελεί αναπόσπαστο κομμάτι της εκπαίδευσης και θα πρέπει να εφαρμόζεται σε όλο τον οργανισμό και να περικλείει στις διαδικασίες της όλα τα ενδιαφέροντα μέλη, τους φοιτητές, το ακαδημαϊκό προσωπικό, το διοικητικό προσωπικό, τους αποφοίτους και τους επαγγελματίες της αγοράς – δυστυχώς στην Ελλάδα δεν υπάρχει σύνδεση όλων των τμημάτων ΑΕΙ με την αγορά. Σύμφωνα με την Ευρωπαϊκή Οικονομική και Κοινωνική Επιτροπή (ΕΟΚΕ) και την UNESCO (United Nations Educational Scientific and Cultural Organization) η ποιότητα στην εκπαίδευση αλλά και στις δημόσιες διοικητικές υπηρεσίες αποτελεί μέσον προώθησης της ισότητας και της κοινωνικής ένταξης αλλά παράλληλα συνιστά και μέσον καταπολέμησης της φτώχειας. Η πολιτική διασφάλισης ποιότητας εκφράζει τη συστηματική, δομημένη και συνεχή προσήλωση του Πανεπιστημίου στην παροχή εκπαίδευσης, έρευνας, διδασκαλίας και υπηρεσιών υψηλής ποιότητας.
Ο ψηφιακός μετασχηματισμός των οργανισμών και οι επιπτώσεις του στη διοίκηση ανθρώπινου δυναμικού
Authors: Εξάρχου Βασιλική
Published: October 2024

Η παρούσα έρευνα επιδιώκει να καταγράψει και να αναλύσει τις απόψεις, στάσεις και αντιλήψεις της διοίκησης του ανθρώπινου δυναμικού σε ελληνικό τριτοβάθμιο δημόσιο ίδρυμα. Με δεδομένο ότι βιώνουμε τη δεύτερη εποχή των μηχανών (WEB 2.0., 4η βιομηχανική επανάσταση) προσδοκώντας στη δημιουργία αληθινής νοημοσύνης των μηχανών αλλά και τη διασύνδεση των ανθρώπων μέσω ενός κοινού ψηφιακού δικτύου, η παρούσα έρευνα μελέτησε την επίδραση των ψηφιακών τεχνολογιών, των δικτύων επικοινωνιών και του λογισμικού στις διοικητικές, οργανωσιακές και εκπαιδευτικές λειτουργίες στα πλαίσια ενός ελληνικού τριτοβάθμιου εκπαιδευτικού ιδρύματος, του Πανεπιστημίου Θεσσαλίας, διερεύνησε σε βάθος τη φύση των προβλημάτων και τέλος διαπίστωσε τα όρια των διαφόρων προσεγγίσεων μέσα από αναλύσεις και σχεδιασμούς. Ο σκοπός της συγκεκριμένης μελέτης ήταν να διερευνήσει την αλληλεπίδραση μεταξύ των εργαζομένων και των διοικητικών στελεχών των τριτοβάθμιων εκπαιδευτικών οργανισμών με τον νέο ψηφιακό τρόπο λειτουργίας των οργανισμών αυτών. Επιπλέον, στόχος ήταν η ανάδειξη της ανάγκης για ψηφιακή αναδιοργάνωση των διαδικασιών προκειμένου να ανταποκριθούν στις νέες απαιτήσεις, η παρουσίαση εργαλείων ψηφιακού μετασχηματισμού, καθώς και η αναγνώριση ευκαιριών βιώσιμης ανάπτυξης στο νέο ψηφιακό περιβάλλον. Επιπλέον, εξετάστηκε η δυνατότητα και η επιτευξιμότητα της σύγχρονης διοίκησης να ανταποκριθεί στις προκλήσεις της παγκοσμιοποίησης και των γρήγορων τεχνολογικών εξελίξεων, καθώς και η ικανότητά της να προσαρμοστεί σε ένα εξαιρετικά δυναμικό περιβάλλον.
Συναισθηματική Νοημοσύνη, Ακαδημαϊκή εξουθένωση και Ακαδημαϊκή δέσμευση σε φοιτητές & φοιτήτριες Ειδικής Αγωγής
Authors: Δανιηλίδου Αθηνά , Πλατσίδου Μαρία , Κασάπογλου Ειρήνη
Published: October 2024

Προηγούμενες έρευνες έδειξαν ότι η συναισθηματική νοημοσύνη φοιτητών και φοιτητριών συσχετίζεται αρνητικά με την ακαδημαϊκή εξουθένωση και θετικά με την ακαδημαϊκή τους δέσμευση. Η παρούσα έρευνα εξετάζει την υπόθεση ότι η ακαδημαϊκή δέσμευση διαμεσολαβεί στην προβλεπτική σχέση της ακαδημαϊκής εξουθένωσης από την συναισθηματική νοημοσύνη. Στην έρευνα συμμετείχαν 93 φοιτητές Ειδικής Αγωγής. Η μέτρηση της συναισθηματικής νοημοσύνης έγινε με το Schutte Emotional Intelligence Scale, η μέτρηση της ακαδημαϊκής εξουθένωσης με το Maslach Burnout Inventory-Student Survey και η μέτρηση της ακαδημαϊκής δέσμευσης με το Utrecht Work Engagement Scale-Student Survey. Τα αποτελέσματα έδειξαν μέτρια συναισθηματική νοημοσύνη, μέτρια προς υψηλή ακαδημαϊκή δέσμευση και μάλλον χαμηλή ακαδημαϊκή εξουθένωση των φοιτητών/ριών. Η συναισθηματική νοημοσύνη προβλέπει μόνο την προσωπική επίτευξη ενώ η ακαδημαϊκή δέσμευση προβλέπει την αποπροσωποποίηση και της προσωπική επίτευξη. Τέλος, διαπιστώθηκε ότι η ακαδημαϊκή δέσμευση διαμεσολαβεί μερικώς στην σχέση ανάμεσα στην συναισθηματική νοημοσύνη και την προσωπική επίτευξη. Τα αποτελέσματα αναδεικνύουν την σημασία σχεδιασμού ακαδημαϊκών παρεμβάσεων οι οποίες να περιλαμβάνουν διδακτικές στρατηγικές που να ενισχύουν την ακαδημαϊκή δέσμευση των φοιτητών/ριών.
Παιδική ηλικία, παιδί και εκπαίδευση
Authors: Κατσιγιάννης Μιχάλης
Published: October 2024

Το παρόν άρθρο εντάσσεται στο ευρύτερο πλαίσιο της –θεωρητικής– μελέτης των εκπαιδευτικών διαδικασιών και μηχανισμών. Βασικός στόχος είναι να παρατεθεί μια κριτική –και αποδομητική– ανάγνωση του πώς οι διαδικασίες και οι μηχανισμοί αυτοί/ες μπορεί να λειτουργούν ως –και μέσα σε– συστήματα εξουσίας. Θα εστιάσω σε τρία αλληλένδετα πεδία: το καθεστώς της παιδικής ηλικίας, την κατηγορία ‘παιδί’ και την εμπλοκή της εκπαίδευσης σε αυτά. Ειδικότερα, επιχειρώ μία θεωρητική προσέγγιση της παιδικής ηλικίας, όχι ως κάτι φυσικό και ουδέτερο, αλλά ως κοινωνικο-πολιτισμική επινόηση και κατασκευή και, συγκεκριμένα, ως πλαίσιο κανονικοποίησης των σωμάτων και των σκέψεων των παιδιών. Σε αυτή την κατεύθυνση, ειδική έμφαση θα δοθεί στο πώς το πεδίο της –αναπτυξιακής κυρίως– ψυχολογίας φαίνεται να παρέχει ένα επιστημονικό περικείμενο εντός του οποίου στοιχειοθετείται και τεκμαίρεται ως αναγκαία η διαχείριση του παιδιού από τους/τις ενηλίκους. Στο πλαίσιο αυτό, θα συζητηθεί εκτενέστερα η σχέση του παιδιού με τον θεσμό της εκπαίδευσης, εστιάζοντας στην εξουσιαστική διάρθρωση αυτής της σχέσης. Το βασικό συμπέρασμα στο οποίο θα καταλήξω είναι ότι η δράση του παιδιού (ειδικά εντός του σχολείου) τείνει να δεσμεύεται –και να εξαντλείται– στον ρόλο του/της παθητικού/ής μαθητή/τριας, του/της μαθητή/τριας που εκτίθεται σε και λαμβάνει απαντήσεις, αντί να θέτει ερωτήματα και να συγκαθορίζει το πλαίσιο και το περιεχόμενο της μαθησιακής διαδικασίας.
Απόψεις και εμπειρίες νηπιαγωγών για το Εκπαιδευτικό Δράμα σε σχέση με το Ενταξιακό Ζητούμενο.
Authors: Πέλου Κατερίνα
Published: October 2024

Το εκπαιδευτικό μας σύστημα παρόλες τις νομοθετικές ρυθμίσεις και τις δεσμεύσεις που προκύπτουν από Διεθνείς συμβάσεις (Unesco 1994· United Nations 2006) δεν έχει καταφέρει να εντάξει ουσιαστικά τους ανάπηρους μαθητές και μαθήτριες στο γενικό σχολείο και να ανταποκριθεί στον αντισταθμιστικό του ρόλο. Το Εκπαιδευτικό Δράμα προβάλλει ως μια εναλλακτική πρόταση στην εκπαιδευτική διαδικασία, ως ένα συμπεριληπτικό εργαλείο μιας διαφοροποιημένης εκπαιδευτικής πρακτικής .Η συγκεκριμένη έρευνα θέτει ως πρωταρχικό σκοπό της να ερευνήσει τις απόψεις και εμπειρίες νηπιαγωγών γενικής αγωγής, οι οποίες  εργάζονται σε νηπιαγωγεία της πρωτοβάθμιας εκπαίδευσης του νομού Αττικής, αναφορικά με τον τρόπο που οργανώνουν και υλοποιούν τη διδακτική μορφή του Εκπαιδευτικού Δράματος. Συγκεκριμένα, παρουσιάζονται τα πορίσματα της έρευνας η οποία, αξιοποιώντας την ποιοτική μεθοδολογική προσέγγιση, μελετά τη συμβολή του Εκπαιδευτικού Δράματος στον επιστημονικό διάλογο για τις διδακτικές πρακτικές στο Νηπιαγωγείο, υπό το πρίσμα της ενταξιακής εκπαίδευσης. Βάσει των αποτελεσμάτων το Εκπαιδευτικό Δράμα, όπως οργανώνεται και υλοποιείται σε προσχολικές τάξεις, σκιαγραφείται ως μια ενταξιακή διδακτική μορφή, με τις πρακτικές της να διαθέτουν τα χαρακτηριστικά της διαφοροποιημένης διδασκαλίας. Ως ενταξιακή διδακτική μορφή θέτει σε διερεύνηση τόσο το μαθητή του Νηπιαγωγείου στη διαδικασία προσέγγισης της γνώσης, όσο και το ευρύτερο προσχολικό πλαίσιο (τι διδάσκεται στο Νηπιαγωγείο, πώς διδάσκεται, ποιος ο ρόλος του Νηπιαγωγού και του νηπίου στην όλη διαδικασία). Παράλληλα, εντοπίζεται μια αντίφαση ανάμεσα στον ενταξιακό χαρακτήρα του Εκπαιδευτικού Δράματος, (το οποίο συνάδει με τις Αρχές και Γνωστικές Περιοχές του Νέου Αναλυτικού Προγράμματος για το Νηπιαγωγείο) και την απουσία του από το Πρόγραμμα Σπουδών των Προπτυχιακών Φοιτητών των Τμημάτων Προσχολικής Αγωγής.
12 tips for integrating the 12 Practitioner Values to improve clinical supervision for neurodiverse learners
Authors: Virji Safiya
Published: October 2024

With the NHS Long Term Workforce Plan requiring clinical placements to accommodate up to 50% more learners, the pressure on clinical educators to maintain high-quality learning environments is becoming increasingly intense. Neurodiverse learners face significant barriers in busy, fast-paced environments, making the cultivation of supportive and adaptive learning spaces essential to ensure all learners have the opportunity to thrive in a healthcare system under immense demand. This article is aimed at empowering clinical educators to lead inclusive placements through implementation of advanced supervision skills to support neurodiverse learners. These are presented as 12 practical strategies, each aligned with the 12 Practitioner Values, for fostering inclusive professional relationships. By offering actionable ‘tips’, this article addresses both the moral imperative to meet diverse learning needs and the systemic necessity of building a more inclusive workforce.
Interfejs zamiast konwencji: listy ucieleśnione. Medialne przemiany powieści epistolarnej
Authors: Przybyszewska Agnieszka
Published: October 2024

Artykuł poświęcony jest współczesnym odmianom powieści epistolarnej, przy czym charakterystyka zawężona jest do drukowanych i cyfrowych form odświeżających gatunek poprzez wyakcentowanie roli interfejsu powieści w listach i jego semantyczne sfunkcjonowanie. Autorka tym samym charakteryzuje najnowsze formy epistolarne w kontekście textual materialism i określa je jako letter-bound genere, jednocześnie zestawiając najnowsze opracowania z kanoniczną Teorią listu Stefanii Skwarczyńskiej. Najważniejsze analizowane w szkicu przykłady to:  liberacka powieść epistolarna i jej cyfrowa remediacja (seria Griffin & Sabine Nicka Bantocka oraz The Ceremony of Innocents), epistolarna interaktywna książka artystyczna wrażliwa na dotyk czytelnika (To You Yioty Demetriou i Toma Abby), epistolarna interaktywna fikcja mistrzyni gatunku Emily Short (First Draft of the Revolution), cyfrowa biografia w listach (Hayleyworld Lisy Gee) a także chat stories publikowane na platformie Suspects, projekt The Flowers Letters Hannie i Michaela Clarków oraz apokryficznie epistolarne reedycje klasyki w opracowaniu Barbary Heller.
Sołomija Pawłyczko: przekraczając tabu
Authors: Shtepenko Oleksandra
Published: October 2024

Sołomija Dmytriwna Pawłyczko była literaturoznawczynią, publicystką, tłumaczką, doktor habilitowaną nauk filologicznych, profesorem Narodowego Uniwersytetu „Akademia Kijowsko-Mohylańska”, członkinią Związku Pisarzy Ukrainy. Jako jedna z pierwszych ukraińskich badaczek wprowadziła do literaturoznawstwa ukraińskiego dorobek studiów feministycznych oraz badań postkolonialnych.
The Two Components of the Modern Novel
Authors: Freise Matthias
Published: October 2024

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Powieści wspomnieniowe Andrzeja Chciuka „Atlantyda” i „Ziemia księżycowa” jako formy wielogatunkowe
Authors: Yavorska Oksana
Published: October 2024

Zapoczątkowana w romantyzmie tendencja do przekraczania tradycyjnego systemu gatunków literackich sprawiła, że wyróżniającą cechą literatury pięknej XX wieku stało się zacieranie granic pomiędzy odrębnymi rodzajami i gatunkami, spowodowane ich przenikaniem się i oddziaływaniem na siebie. Szczególnie to widać na przykładzie powieści.
The Loan Fee Anomaly: A Short Seller’s Best Ideas
Authors: Engelberg Joseph E. , Evans Richard B. , Leonard Greg , Reed Adam V. , Ringgenberg Matthew C.
Published: October 2024

We find that equity loan fees, which have been largely ignored by the anomalies literature, are the best predictor of cross-sectional returns. When compared with 102 other anomalies and other short-selling measures, the loan fee anomaly has the highest monthly long-short return (4.01%), the highest monthly Sharpe Ratio (0.66), and, unlike other anomalies, exhibits strong persistence throughout the sample. Although prior work has shown that existing anomalies reside in high loan fee stocks, we find that 42% of loan fee outperformance is due to unique information not contained in other anomalies. Future papers that examine cross-sectional predictors of returns should include the single most effective predictor: loan fees.

This paper was accepted by Victoria Ivashina, finance.

Supplemental Material: The online appendix and data files are available at https://doi.org/10.1287/mnsc.2023.00152 .
Education of endoscopy nurses in Europe: diversity for patients’ safety
Authors: Beilenhoff Ulrike
Published: October 2024

Ulrike Beilenhoff explores the differing gastrointestinal nursing education and practice models across Europe.
Motivations for surgery to the nose
Authors: Auer Deborah
Published: October 2024

Dr Deborah Auer discusses the ways in which traumatic expriences impact patient decision-making and motivations for elective surgery
BAMAN autumn updates
Authors: Baker Anna
Published: October 2024

September is busier than ever as we prepare to enter the busiest time of the year. It has been a highly productive time for BAMAN (formerly BACN) with many exciting developments to share regarding projects across our association
Unraveling Neurodevelopmental Disorders: Signalling Pathways as Potential Targets for Therapeutic Intervention in Autism Spectrum Disorder
Authors: Suchitra M. R. , P. S Yogitha
Published: October 2024

Introduction: Autism Spectrum Disorder (ASD) presents a multifaceted challenge with limited therapeutic options and a need for early biomarkers. Understanding disrupted signalling pathways offers promise for intervention and assessment. Methods: Literature review spanning genetic, pre-clinical, and patient studies elucidating pathways implicated in ASD pathogenesis, including melatonin, mTOR, Retinoic acid, Hedgehog, Notch and Wnt signalling. Results: Core components of key signalling pathways, such as melatonin, mTOR, Retinoic acid, Hedgehog, Notch and Wnt, are dysregulated in ASD. These pathways regulate crucial aspects of the nervous system, including immune function, neuronal growth, neurotransmission, and metabolism. Discussion: Manipulating these pathways could potentially modify ASD traits by influencing brain development and immune homeostasis. Targeting specific nodes within these pathways may offer novel therapeutic approaches for ASD management. Additionally, identifying biomarkers associated with pathway dysregulation could enable earlier diagnosis and monitoring of disease progression. Conclusion: Understanding the intricate interplay of signalling pathways in ASD pathogenesis provides insights into potential therapeutic targets and biomarkers. Further research into the manipulation of these pathways and their impact on ASD traits is warranted to advance personalized treatment strategies and improve outcomes for individuals with ASD.
Reviewing Genetic Testing for Lupus: Implications for Nephritis
Authors: Rajappa Margret Chandira , Muthumani Karthikeyan , Soosai John Kennedy Mariya , Vezhaventhan Vignesh , Solomon Gracy Gladin , Gnanamoorthi Sanjay , Sivaji Ranjithkumar
Published: October 2024

Genetic testing has significantly changed our understanding and treatment of systemic lupus erythematosus (SLE), particularly its severe manifestation, lupus nephritis (LN). Nephrology faces great difficulty with LN, which is characterized by severe inflammation and kidney damage. To create individualized treatments, it is essential to identify the genetic variables that influence the LN susceptibility and progression. This review highlights the importance of genetic testing in diagnosing and managing LN, covering genetic predispositions, common markers, the role of ethnicity, specific renal genes, and epigenetic factors. Key genetic markers such as HLA-DRB1, ITGAM, FCGR2A, and IRF5 have been linked to LN, impacting immune regulation and disease progression. Asians, African Americans, and Hispanics have greater prevalence rates of genetic susceptibility than Caucasians, suggesting that ethnicity plays a major role in genetic vulnerability. Genes like APOL1, PDGFRA, and HAS2 play vital roles in renal function and fibrosis, affecting disease outcomes. New treatment targets are provided by epigenetic mechanisms that control gene expression in LN, such as DNA methylation and histone alterations. The progress made in genome-wide association studies (GWAS) has led to the discovery of new genetic loci linked to LN, which has improved our knowledge of its pathogenesis. This review highlights the critical role of genetic testing in LN, emphasizing its potential to improve diagnosis, treatment, and patient outcomes through personalized medicine.
Exploring the Versatility of Ferrocene and its Derivatives: A Comprehensive Review
Authors: Jagdale Deepali , Battellu Kaustubh , Bhosale Sampada , Sawant Yashashree , Nadar Gayatri
Published: October 2024

Ferrocene is a remarkable organometallic compound with an iron ion sandwiched between two cyclopentadienyl rings. This unique molecular structure and diverse characteristics such as improved solubility, altered reactivity, and enhanced biological activity make them potential candidates for drug development and diverse applications including cancer therapy. Additionally, ferrocene-based compounds exhibit a lower tendency to induce severe side effects, making them a safer option for cancer treatment. They also have shown potential in overcoming resistance encountered by platinum compounds in treating certain types of cancer. The three primary metabolic pathways for ferrocene include oxidation, cyclization catalyzed by acid, and hydroxylation, forming quinone methide, cyclic indene, and allylic alcohol, respectively. Building on this foundation, researchers have delved deeper into synthesizing and assessing novel ferrocene derivatives to enhance their effectiveness in addressing cancer and other illnesses. This review comprehensively examines potential derivative reactions, highlighting the possibilities for tailoring these compounds to achieve specific therapeutic objectives.
Intranasal Administration of Standardized Extract of Gotu Kola Leaves Against Nitroglycerine-Induced Recurrent Migraine-Like Pain in Rats
Authors: Thakurdesai Prasad Arvind , Bhalerao Pooja Abhay , Aswar Urmila Manoj
Published: October 2024

The present study aimed to determine the efficacy of intranasal administration of a standardized extract of Gotu kola, i.e., Centella asiatica (L.) Urban (INDCA-NS) with marker triterpenoids for the prevention of nitroglycerine- (NTG)-induced recurrent migraine in rats. Adult rats of both sexes in a group of 12 were administered intraperitoneal NTG (10 mg/kg) on alternate days (D1 to D9) and once daily intranasal solutions of either vehicle (saline, 50 µL/rat/day), sumatriptan (80 µL/rat/day of 12 mg/ml) as positive control, or INDCA-NS (10, 30, or 100 µg/rat/day) for 21 days. Behavioral and biochemical parameters related to concurrent migraine pain (facial expressions on the grimace scale, thermal hyperalgesia, mechanical allodynia, and plasma and brain levels of pituitary adenylate cyclase-activating polypeptide and nitric oxide), and stress (photophobia and cortisol levels in the brain and serum) were measured. The intranasal administration of INDCA-NS prevented NTG-induced migraine-like pain, photophobia, and stress in a dose-dependent manner. At the same time, sumatriptan alleviated pain and anxiety but not photophobia. In conclusion, the intranasal administration of INDCA-NS showed prophylactic efficacy against recurrent NTG-induced migraine pain in rats.
Chromatographic Profiles of Polyphenols in the Herbs of Artemisia campestris L. and Artemisia ludoviciana Nutt.
Authors: Shanaida Mariia , Korablova Olha , Rakhmetov Dzhamal , Sydor Bohdanna , Shanaida Volodymyr , Hudz Nataliia , Brindza Ján
Published: October 2024

This study aimed to analyze the compositions of flavonoids and phenolic acids in the aerial parts of two Artemisia L. species (Artemisia ludoviciana Nutt. and Artemisia campestris L.) when grown in Ukraine. High-performance liquid chromatography analysis (HPLC) detected the presence of 11 flavonoids and 10 phenolic acids in the plant materials under study. Among the phenolic acids, chlorogenic acid was the most abundant in the raw material of both species (14.503 mg/g in Artemisia ludoviciana and 4.504 mg/g in Artemisia campestris). The main flavonoids in the Artemisia ludoviciana herb decreased in the following order: flavanone-7-O-glycoside (naringin) (21.924 mg/g) > fisetin (13.068 mg/g) > kaempferol-3-b-glucoside (5.119 mg/g) > rutin (1.295 mg/g). In comparison, in Artemisia campestris raw material the order was: flavanone-7-O-glycoside (7.525 mg/g) > fisetin (2.933 mg/g) > rutin (1.355 mg/g). Since the predominant polyphenols have demonstrated valuable therapeutic potential, the data obtained could be considered for further exploration of their biological activities.
Neem Leaves Extract Reduces Sex Steroids and Gonadal Function in Female Wistar Albino Rats
Authors: Al-awadhi Rana Mohammad , Abdelrazek Heba Mohammed Ahmed , Abouelhassan Eman Mohammed , Kamel Marwa Samir , Attia Nayrouz Ali , Awad Asem Abdelmonem , Saad Mohamed Refaat
Published: October 2024

The neem plant (Azadirachta indica) is one of the most important medicinal plants in Asia and Africa. This study aimed to investigate the possible anti-fertility potential of dietary neem leaves' extract in female Wistar albino rats as. This model could be further applied to stray dogs. In this experiment 24 adult female albino Wister rats were divided into two groups: control and treated with neem leave extract, they were tested for estrous regularity by vaginal smears, progesterone, and estrogen hormone were measured. Ovarian caspase-3 expression and histopathological inspection were examined. The results have revealed reducing sex steroids, increment in ovarian caspase-3 expression, and histological deteriorations in the ovary and uterus. The study concluded that neem flower extract can be used as an antifertility agent in animals.
Monitoring the Seroprevalence of Herpes Simplex Virus-1 Among Egyptian Hemodialysis Patients
Authors: Ibrahim Mohamed N.
Published: October 2024

Background: Hemodialysis patients are at high risk for infections due to their compromised immune systems. Herpes Simplex Virus (HSV) infections can lead to severe complications in this population. Despite its clinical significance, comprehensive data on the seroprevalence of HSV among hemodialysis patients are limited. Objective: This study aims to evaluate the seroprevalence of HSV-1 among Egyptian hemodialysis patients. Methods: A cross-sectional study was conducted with 218 participants (116 females and 102 males). Among these, 132 (60.6%) were undergoing hemodialysis, while 86 (39.4%) had normal kidney function and were free from HCV, CMV, and HIV infections. Serum samples were analyzed for IgG antibodies against HSV-1. Statistical analyses were performed to determine HSV seroprevalence. Results: The study observed a significantly higher prevalence of HSV-1-IgG antibodies in hemodialysis patients (84.1%) compared to the control group (66.3%, P<0.01). Additionally, HSV-1-IgM positivity was also higher in the hemodialysis group (41.6%) compared to the control group (32.6%, P<0.05). These findings highlight the need for vigilant monitoring and preventive strategies for HSV infections in hemodialysis patients.
Identification of Novel Compounds Targeting the Liver X Receptor (LXR): In-silico Studies, Screening, Molecular Docking, and Chemico-pharmacokinetic Analysis
Authors: Arifuzzaman Sarder , Labu Zubair Khalid , Rashid Md. Harun -Or- , Laboni Farhina Rahman , Khatun Mst. Reshma , Ali Md Sajib , Hossain Shadek , Chowdhury Nargis Sultana
Published: October 2024

Studies have demonstrated the association between LXR activity dysregulation with many diseases, including atherosclerosis, diabetes and cancer. In recent years, several LXR agonists have surfaced, but none have been approved for human use due to adverse effects or unforeseen reasons. In this study, we first analysed the mRNA and protein expression of LXRs across tissues, network and pathway analysis, and reinterpreted their physiological function and disease association by utilizing multiple biological data repositories, including RNA-seq human protein atlas, DisGeNET, etc. Then, we performed ligand-based virtual screening, chemico-pharmacokinetic analysis, docking and simulation to identify potential new compounds. Our findings of mRNA, protein expression, network and disease enrichment analysis reveal diverse physiological functions of LXRs addressing the possibility of pharmacological manipulation with small molecules would provide therapeutic strategies for disease management. Evaluation of the docking and chemico-pharmacokinetic properties directed to the selection of LXR-623 and AZ876 as promising candidates for LXR-α and LXR-β for further in-silico investigation. Comprehensive screening for new ligands targeting LXRs based on the chemical structures of LXR-623 and AZ876, identified ZINC000005399501 and ZINC000021912941 with the highest binding affinity (−9.8 and −10.7 kcal/mol) for LXRα and LXRβ, respectively. Our results also supported in simulation study, along with favorable chemico-pharmacokinetic features.
Phytochemical and Toxicity Evaluation of Methanol Extracts of Leaves and Fruits of Zanthoxylum rhetsa (Rutaceae)
Authors: Mallya Rashmi , Suvarna Vasanti
Published: October 2024

Zanthoxylum rhetsa is extensively utilized in the realm of gastronomy and therapeutics. However, existing literature lacks any documentation concerning the systematic assessment of the toxicity characteristics of the foliage and produce of Z.rhetsa. Consequently, the present inquiry was executed to appraise the immediate toxicity examinations of the methanol extract derived from the leaves and fruits in mice, in accordance with the regulations delineated by the Organization for Economic Cooperation and Development (OECD 420, 2001). In this investigation, a solitary dosage of 5000 mg/kg body mass of the specimen was administered to female mice, as stipulated by the OECD guidelines. Daily surveillance ensued for a total of fourteen days, with the objective of detecting any indications of toxicity or fatality. Upon the culmination of this two-week period, a comprehensive analysis involving hematological, biochemical, and histopathological evaluations was conducted. The outcomes of the immediate toxicity investigations evinced that neither the leaves nor the fruits extract exhibited any morbidity, conspicuous alterations in corporeal mass, nor any discernible impairment in behavioral or motor neural activities in the mice. The haematological and serum biochemical parameters did not exhibit significant disparities from the control groups. These findings were corroborated by histopathological investigations, wherein no abnormalities or pathological alterations were detected in the vital organs. The LD 50 (oral lethal dose) of the samples was determined to exceed 5000 mg/kg body weight. Consequently, the methanol extract of leaf and fruit extract of Z.rhetsa can be regarded as non-toxic and demonstrated a broad margin of safety for its therapeutic application.
Clinicopathological Study of Herpes Simplex Esophagitis in a Tertiary Centre in India
Authors: Nathany Shrinidhi , Sagar Siddharth , Jaiprakash Padmapriya , Madiyal Mridula
Published: October 2024

Introduction and objectives: Herpes Simplex Virus (HSV) is a common viral pathogen, known to cause symptomatic disease in the immunocompromised hosts; however, it may occur in healthy individuals as well. Among the varied manifestations of the disease, involving skin, central nervous system and gastrointestinal systems, HSV esophagitis is a less studied entity from the Indian perspective. The aim of the study is to compare clinical, histologic and serologic data of HSV esophagitis patients. Materials and methods: 27 cases, proved to have HSV esophagitis on endoscopic biopsy were included, and the pertinent clinical and serologic characteristics were studied. Results: We found a male preponderance (p<0.01), which has been a well-established risk factor. Other risk factors are retroviral coinfection, Type 2 Diabetes Mellitus, immunosuppression, chemoradiation etc. among others. Eleven patients had retroviral coinfection, with CD4 counts of > 200/μL in all. Anti HSV 1 IgM antibody was most commonly detected on serology. HSV esophagitis affects immunocompromised patients more often than immunocompetent ones. Odynophagia and dysphagia are the most common symptoms. Histological evaluation for the characteristic inclusions helps in early diagnosis. The novelty of this study rests on the clinicopathological and serologic correlation, for a better understanding of the disease process, to prompt future large scale studies on the same. Conclusion: Herpes simplex esophagitis is most seen in immunocompromised patients. Apart from retroviral illness, other risk factors include diabetes mellitus, patients undergoing chemotherapy and other malignancy. CD4 counts in our series was >200/μL, in contrast to the cutoff of <200/μL described in literature.
A comparison of the Anti-diabetic Potential of Magnetized Water, Metformin, and Their Combination in A Rat Model of Type II Diabetes
Authors: Sayed Alaa H. , Ahmed Amira S. , Hozayn Mahmoud , Mohawed Ola A. M. , Ahmed Hanaa H. , Abohashem Rehab S.
Published: October 2024

DM is a collection of metabolic disorders brought on by abnormalities in secretion, action, or combination of both of insulin. Nowadays, many efforts are made to change lifestyles to get a moderate outcome with the fewest possible side effects and reduce complications. Although magnetized water (MW) has been promoted since 1930s, it has not received wide approbation since its effectiveness is still in question; however, the therapeutic potential of MW on the body has been reported. This study investigated the impact of MW supplementation on glucose, insulin, antioxidant status, inflammatory condition, DNA fragmentation and gene expression associated with the metabolism of glucose in STZ-induced diabetes in rats. Adult female Wistar rats (6 groups) were used in this study: G1: Control group+ tap water (TW); G2: Control group+ MW; G3: Diabetic group+ TW; G4: Diabetic group+ MW; G5: Diabetic group+ metformin (Met)+ TW; G6: Diabetic group+ Met+ MW. Additionally, lowering serum glucose and raising insulin level, MW consumption repaired DNA damage, enhanced antioxidant status, reduced inflammatory response, and upregulated genes linked to glucose metabolism. Furthermore, as shown by the histological analysis of pancreatic tissue sections, supplementation with MW could reverse the detrimental effects of STZ on the pancreas. This study offers novel insights into how MW consumption can help reduce T2DM by reducing hyperglycemia, restoring the equilibrium between antioxidants and oxidants, reducing inflammatory responses, and altering genes involved in glucose metabolism. Therefore, MW may be used as an adjuvant in T2DM management.
Differences in Femoral Medullary Canal Dimensions in the USA and East Asian Populations
Authors: Siddiqi Najam , Chao Edmond YS
Published: October 2024

With emerging technologies and improved operative techniques, cementless total hip arthroplasty is becoming more popular and showing better results. The femoral prosthesis and intramedullary nail should precisely fit in the medullary canal to prevent micromotion and loosening. Most of the femoral prosthesis and nail designs are made from the data obtained from Caucasian femur and may not press fit if used in Asian populations. This study compares the femoral medullary canal diameter in American and Oriental populations at different bony levels. A total of 245 dry femora were collected which included 47 from United States, 77 from China, 44 from Japan, 50 from Korea and 27 from Taiwan, and plan radiographs were taken. Radiographs were digitized to measure the medullary canal width at 20% (lesser trochanter; LT), 35% (supra-isthmus; SI), 50% (mid-isthmus; MI), 65% and 80% of the total femur length. The results revealed significant differences in the medullary canal width between the US and East Asian Oriental populations. The medullary canal in the US population was significantly larger at the LT, SI, MI, and 65% but significantly smaller at 80% of the femoral shaft length compared to the East Asian populations. Among the East Asian populations, significant differences were obse4rved between the Chinese and Taiwanese populations as well as the Japanese and Taiwanese populations. The Taiwanese population had the smallest femoral medullary canal size among the east Asian populations. We conclude that there are significant differences in the femoral medullary width between the American and East Asian populations. These results will be useful for surgeons operating on the proximal or distal femur.
Enhancement of Osteoblastogenesis in the hFOB 1.19 Cell Line by the Induction of the n-Butanol Fraction Derived from Marsilea crenata C Presl. Leaves.
Authors: Aditama Agnis Pondineka Ria , Asiyah Siti , Hariyani Tintin , Nuraisya Wahyu , Mustofa Linda Andri , Setyowati Anis
Published: October 2024

Osteoporosis is a disease characterized by bone loss, which can be treated by increasing the bone formation process. A marker of increased bone formation processes is the activity of the transcription factor Osx which stimulates the formation of Ocn. M. crenata leaves contains phytoestrogens which are thought to increase bone formation. The purpose of this research was to prove that the n-butanol fraction from the leaves of M. crenata can increase bone formation in hFOB 1.19 osteoblast cells by increasing the activity of the transcription factors Osx and Ocn. hFOB 1.19 cells that had reached confluence were given n-butanol fraction at a dose of 62.5, 125, and 250 µg/L, and Genistein 2.5 µg/ml as a positive control for phytoestrogens. Increased bone formation was identified through the expression of Osx and Ocn using the immunocytochemical method with CLSM. The findings indicate that the application of various dosages of the n-butanol fraction derived from the leaves of M. crenata has a positive impact on bone formation in hFOB 1.19 cells. The best dose was determined to be 250 µg/L, with a statistically significant difference of p<0.005. The n-butanol fraction obtained from M. crenata leaves was found to increase the expression of Osx and Ocn in hFOB 1.19 cells, indicating its potential to enhance bone production.
A Hybrid Approach for CT Image Noise Reduction Combining Method Noise-CNN and Shearlet Transform
Authors: Katta Swapna , Singh Prabhishek , Garg Deepak , Diwakar Manoj
Published: October 2024

The presence of gaussian noise commonly weakens the diagnostic precision of low-dose CT imaging. A novel CT image denoising technique that integrates the non-subsampled shearlet transform (NSST) with Bayesian thresholding, and incorporates a modern method noise Deep Convolutional neural network (DCNN) based post-processing operation on denoised images to strengthen low-dose CT imaging quality. The hybrid method commences with NSST and Bayesian thresholding to mitigate the initial noise while preserving crucial image features, such as corners and edges. The novel aspect of the proposed approach is its successive application of a DnCNN on initial denoised image, which learns and removes residual noise patterns from denoised images, thereby enhancing fine detail preservation. This dual-phase strategy addresses both noise suppression and image-detail preservation. The proposed technique is evaluated through the use of metrics, such as PSNR, SNR, SSIM, ED, and UIQI. The results demonstrate that the hybrid approach outperforms standard denoising techniques in preserving image quality and fine details.
MTHFR Polymorphisms and Plasma Homocysteine in Early-Onset Alzheimer's Disease: A Case-Control Study
Authors: Hamad Nasir Abdelrafie , Eltayeb Lienda Bashier , Yassin Habab Merghani
Published: October 2024

Background: Early-onset Alzheimer's disease (EOAD) constitutes 1-2% of all Alzheimer's cases, presenting with poorer prognosis, progressive symptoms, and reduced life expectancy compared to late-onset Alzheimer’s, thereby increasing socioeconomic burden. Elevated plasma homocysteine levels due to MTHFR gene polymorphisms are implicated in Alzheimer's etiology. The present study aims to explore the association between MTHFR gene polymorphisms in Sudanese population. Methods: Seventy-three EOAD patients were assessed for MTHFR C677T and A1298C polymorphisms, alongside plasma homocysteine levels. Results: Significant associations were observed between CT and TT alleles, elevated plasma homocysteine levels, and EOAD. Conclusion: MTHFR C677T polymorphism was associated in EOAD in Sudanese population. Elevated plasma homocysteine levels might frame this association and potentially contribute to the disease onset before the age of 65.