bluuebunny/crossref_metadata_2025 huggingface dataset:
Strategic Management Insights into Housewives Consumptive Shopping Behavior in the Post COVID-19 Landscape
Authors: Purnama Suryari , S Bangun Cicilia
Published: January 2024

Digital wallets can be accessed using a mobile phone Apart from that, marketplace users are used as a tool to make it easier for consumers to shop online. One of the reasons why marketplaces are famous is because of their ease and comfort in use. This research aims to see the influence of digital wallets and marketplace use on consumer shopping behavior among housewives after the Covid 19 pandemic.The population is housewives in DKI Jakarta, with data collection techniques distributing questionnaires to a sample of 113 housewives. Sampling withpurposive sampling, has criteria: respondents are limited to only housewives who are at least 18 years old, respondents have income worth ≤ IDR 5 million and respondents have used marketplaces and digital wallets and are domiciled in DKI Jakarta. Data processing used multiple regression analysis to obtain Y = 0.290 + 0, 139X1 + 0, 576X2 + c. From this equation it is obtained: 1. There is no influence of digital wallets on consumptive shopping behavior among housewives after the Covid 19 pandemic, 2 There is an influence of the marketplace on consumptive shopping behavior among housewives after the Covid 19 pandemic, 3 There is an influence of digital wallets and marketplaces on consumerist shopping behavior among housewives after the Covid 19 pandemic.
Diseñar para la sustentabilidad en el Siglo XXI
Authors: Encino Muñoz Ana Gabriela
Published: January 2024

El presente artículo aborda la relación entre el paradigma actual de la sustentabilidad y la práctica en las diferentes disciplinas del diseño. Se hace una revisión de los discursos en el Diseño para la sustentabilidad en las últimas décadas con la finalidad de mostrar a los profesionales del diseño las diferentes vertientes que han surgido, su conexión con otros campos del saber y cómo esto ha enriquecido las prácticas de la disciplina. Por último, se presenta una lista de sugerencias para aquellos diseñadores que tienen el compromiso de alinear su trabajo con los principios de la sustentabilidad.
Diseño bioclimático en la arquitectura de hoy
Authors: Gaytán Ortiz Inés del Rocío
Published: January 2024

El presente artículo inicialmente evidencia, la responsabilidad que la industria de la construcción comparte en el daño ejercido sobre el medio ambiente, principalmente en el ámbito urbano. Enseguida, se propone como alternativa ante este desafío, recuperar una de las principales características de la arquitectura: la adaptación al entorno y su clima. El desconocimiento del sitio donde se proyecta, ha provocado que se establezcan tipologías uniformes de edificaciones, provocando gasto innecesario de energía para enfriar y calentar espacios. Finalmente, se propone re pensar la enseñanza arquitectónica, para incluir en ella, al menos cinco de las principales bases del diseño bioclimático.
Transdisciplinariedad de Ing. Civil y Agroindustrial: temas de convergencia
Authors: Vargas Rodríguez Lorena , Alejo López Sergio Jacinto , Fuentes Ramírez Rosalba
Published: January 2024

Se presenta una breve introducción a la Ingeniería y la relación existente entre la Ingeniería Civil y la Agroindustrial, desde el enfoque de una propuesta del uso de materiales sustentables agroindustriales para su empleo en el desarrollo de elementos de las obras civiles; lo anterior con la finalidad de obtener productos que minimicen el deterioro ambiental. En este contexto se ha establecido un ámbito de colaboración multi y trans disciplinario entre la Universidad Autónoma de Aguascalientes y la Universidad de Guanajuato.
Introducción a la Ciencia de los Ámbitos Antrópicos
Authors: Lopez-Leon Ricardo
Published: January 2024

La Ciencia de los Ámbitos Antrópicos es una perspectiva transdisciplinar que tiene por objeto de estudio las relaciones entre el ser humano y el entorno. Entiéndase en este punto entorno como un concepto amplio que involucra las esferas políticas, económicas, sociales, tecnológicas y ambientales. Existen perspectivas clave que anteceden al ámbito antrópico como objeto de estudio, enfatizando la necesidad de estudiar los sistemas artificiales que diseñamos como interfaces para interactuar con el entorno.
Percepción térmica en espacios urbanos patrimoniales. Caso de estudio: Guanajuato
Authors: Vazquez Torres Claudia Erendira , Sotelo Salas Cristina , Grajeda Rosado Ruth
Published: January 2024

Los espacios urbanos desempeñan un papel crucial en la búsqueda por mejorar condiciones de salud humana y ambiental debido a su alta concentración de usuarios y su potencial para implementar de estrategias de mitigación y prácticas sustentables frente a los crecientes niveles de CO2 del ambiente. Los espacios urbanos patrimoniales presentan un reto mayor por su elevado índice de ocupación y a las restricciones normativas para su conservación. Además, el turismo local y foráneo, como fenóme-no socio-económico dinámico, requiere estrategias compatibles con protocolos de calidad ambiental ante los retos sociales actuales. El objetivo de este estudio, fue identificar las condiciones térmicas que influyen en la comodidad de los usuarios al ocupar espacios públicos, y proponer estrategias sustenta-bles de mejora. Se utilizó un método experimental para monitorear el comportamiento térmico en una calle conectada con el centro histórico de Guana-juato, que cuenta con clima templado, y se calificó el estrés térmico en espacios exteriores a través de un índice internacional. Los resultados muestran la necesidad de reducir el estrés térmico de acuerdo con los meses de medición, que derivaron en es-trategias de mejoramiento efectivas para espacios urbanos patrimoniales enfocados en la movilidad sustentable.
Mejoras para la Regulación Microclimática del Entorno Urbano del Antiguo Mercado Municipal de Mexicali, México
Authors: García Haro Alan
Published: January 2024

En entornos urbanos con clima desértico, las condi-ciones térmicas derivadas del incremento proyecta-do de temperaturas debido al cambio climático, el efecto de isla de calor urbana y las altas temperatu-ras que naturalmente se registran en la región, de-mandan estrategias de regulación microclimática en los espacios exteriores urbanos para reducir el estrés térmico de los usuarios y asegurar su óptimo fun-cionamiento. En este contexto, la presente investi-gación plantea una aproximación a la identificación del impacto microclimático de estrategias de dise-ño en los alrededores urbanos del Antiguo Mercado Municipal de Mexicali, México. Con este objetivo se plantearon tres etapas de análisis: 1) mediciones de campo para el análisis detallado del comportamiento térmico del estado actual de los espacios urbanos; 2) planteamiento de distintas estrategias y escenarios de diseño urbano para la mejora microclimática; y 3) evaluación de la influencia térmica de dichas estra-tegias mediante simulación térmica de exteriores en ENVI-met. Finalmente, los resultados presentan la efectividad de las estrategias de diseño urbano pro-puestas en torno a la movilidad y el uso recreativo de los espacios públicos. Donde se identificaron una serie de consideraciones que permiten una respues-ta técnicamente justificada a la adaptación climática del entorno urbano del Antiguo Mercado Municipal de Mexicali.
Aproximación a las nuevas conceptualizaciones de la imagen visual y la Inteligencia Artificial (IA)
Authors: Contreras González María Trinidad , Romero Becerril Julio César , Guadarrama González Jaime
Published: January 2024

El presente trabajo de investigación tiene como objetivo general reflexionar sobre las nuevas conceptualizaciones de la Imagen y de la Inteligencia Artificial (IA) debido a que las actuales herramientas y aplicaciones tecnológicas, permiten la construcción de diversas realidades y contextos análogos o virtuales; es decir, que se establecen representaciones simbólicas que corresponden a elementos conocidos a nivel identitario, pero que se ajustan y se estructuran en posibilidades no imaginadas en primera instancia y que posteriormente permiten la visualización de panoramas emergentes y una diversidad inconmensurable de posibles soluciones ante situaciones cotidianas o también ante problemas complejos. Vale la pena mencionar que las nuevas generaciones convergen y fluyen de manera natural en el manejo de realidades alternas y construyen posibilidades profesionales, de entretenimiento y lúdicas a partir del desarrollo tecnológico actual y de las herramientas que se consolidan con los cambios pregnantes y constantes. La Inteligencia Artificial y la Realidad Virtual convergen de manera común en ámbitos propios del Diseño y también en panoramas cotidianos como lo son los videojuegos, los sistemas de televisión y entretenimiento, las aplicaciones educativas, etc. En el desarrollo del presente texto se utilizó una metodología de corte cualitativa a través del método de revisión documental.
Parámetros del entorno construido y su impacto en el bienestar humano. Teoría y aplicación de métodos y herramientas de evaluación.
Authors: Araya León Maria José , Abella García Ainoa , Guasch Ceballos Ricardo , Peña Andrés Javier
Published: January 2024

El entorno construido y su impacto en el bienestar y salud humanos son analizados en este artículo. Se busca identificar los parámetros del entorno que influyen en el bienestar, cómo se miden y su relación con la salud, para ello se realiza una revisión literaria en la base de datos WOS entre 2008 y 2018. En los parámetros del entorno se muestra una escasa relación entre los estudios aplicados en los materiales y el ser humano, y con poca presencia de la biofilia y la forma. Respecto al ser humano, se encuentra una mayor cantidad de estudios psicológicos en comparación con estudios biológicos.Además, se presentan seis investigaciones empíricas realizadas entre 2018 y 2022. Estos casos tratan de relacionar los efectos psicológicos y biológicos del entorno construido para poder relacionar las mediciones reportadas por los individuos con las mediciones fisiológicas.El artículo concluye que esta línea de investigación es importante para fortalecer tanto la generación de datos como el diseño basado en evidencia en el entorno construido. Se resalta la necesidad de abordar de manera más completa y holística la relación entre el ser humano y su entorno construido para mejorar el bienestar y la salud de las personas.
El real estanco de la nieve en la región Puebla-Tlaxcala, 1774- 1820
Authors: Gutiérrez Carmona Alejandro Francisco
Published: January 2024

Este trabajo muestra los mecanismos legales y económicos que senecesitaron para adquirir un monopolio real, como lo fue el estanco de la nieve, y lo que rodeaba la realización de dicha actividad, debido a que los espacios lúdicos y las fiestas, esencialmente religiosas, jugaron un papel relevante para que se activara la venta de la nieve y el helado. Por otra parte, se observará el comercio clandestino que se realizaba en algunas zonas de Tlaxcala y se hará una comparación de las ofertas por el monopolio mencionado entre dicho lugar, Puebla y la ciudad de México.
El Jazz en México, de su intento de censura a su conquista de los medios
Authors: Fierros Benítez Alejandro Guadalupe
Published: January 2024

El jazz tuvo una relación importante con México desde sus orígenes, ya quela música y la cultura mexicana influyeron en la gestación de dicho género; su presencia en el país, desde las primeras décadas del siglo pasado, fue fundamental para la historia del desarrollo musical del país, así como en la formación del gusto popular. Sin embargo, debido a su lugar de origen y a la ideología del nacionalismo cultural posrevolucionario, su presencia en México fue vista por el Estado como un elemento cultural ajeno y pernicioso para el desarrollo de la identidad cultural mexicana que se buscaba construir.
Social deprivation independently impacts clinical outcomes in patients with chronic lymphocytic leukemia.
Authors: Fegan Gregory , Tod Daniel , Downing Abigail , Elmusharaf Nagah , Pepper Christopher , Fegan Christopher
Published: January 2024

Not available.
A randomized, double-blind study of zinpentraxin alfa in patients with myelofibrosis who were previously treated with or ineligible for ruxolitinib: Stage 2 of a phase II trial
Authors: Verstovsek Srdan , Talpaz Moshe , Wadleigh Martha , Isidori Alessandro , Te Boekhorst Peter , Savona Michael R. , Bose Prithviraj , Pozdnyakova Olga , Mesa Ruben , El-Galaly Tarec C. , O’Sullivan Jennifer , Gamel Katia , Higgins Brian , Katakam Sudhakar , Todorov Boyan , Trunzer Kerstin , Harrison Claire N.
Published: January 2024

Not available.
Psicomotricidad fina en el desarrollo de la inteligencia espacial en niños y niñas de 4-5 años
Authors: Rivas-Pita Lesvia , Moreira-Aizprua Selena , Molina-Ojeda Nancy
Published: January 2024

Este artículo se centra en la importancia de la psicomotricidad fina en el desarrollo de la inteligencia espacial en los niños, que es de vital importancia durante los primeros años de vida y más aún cuando ingresan a una institución educativa, ya que es cuando los niños descubren y exploran su entorno con actividades lúdicas proporcionadas por el maestro. Su objetivo es promover el uso de material didáctico para la estimulación y el progreso de las habilidades espaciales en niños y niñas de 4 a 5 años de edad. La metodología aplicada se basa en la búsqueda de información de diversas fuentes confiables, bajo un enfoque mixto, utilizando el método inductivo, para identificar las particularidades del fenómeno estudiado, enmarcado en un tipo de estudio descriptivo. Entre las técnicas aplicadas, se utilizó la encuesta a los maestros y la observación para los niños. Con los resultados de la investigación, se corroboró la importancia de desarrollar la inteligencia espacial en niños y niñas a través de la psicomotricidad fina, cuán concluyente que es para su aplicación y la calidad del trabajo realizado por los educadores en las actividades, donde fortalecen y favorecen la enseñanza-aprendizaje, ya que a través de estas actividades el niño desarrolla sus habilidades psicomotoras junto con la conciencia espacial.
PENGEMBANGAN KETERAMPILAN BERFIKIR KRITIS PADA REMAJA MELALUI PENERAPAN METODE DEBAT
Authors: Syahdeli Muhamad Ilham , Budiman Rido , Rikmasari Rima
Published: January 2024

In a research journal focusing on community service programs aimed at developing critical thinking skills through debate methods in high schools, the research results indicate that this program has significantly enhanced the critical thinking abilities, speaking skills, and argumentation skills of male and female students. The program has provided valuable experiences in research, teamwork, and a deeper understanding of complex issues. Participants in the program have also reported improvements in their ability to communicate clearly and assertively, boosting their confidence in expressing their opinions and effectively responding to questions and counterarguments.Throughout the debate process, students have had the opportunity to delve into specific topics, aiding them in better comprehending complex issues. This, in turn, contributes to more critical assessments and better decision-making across various aspects of life.Expanding the implementation of this program to various high schools is expected to assist more students in developing crucial critical thinking skills vital for both education and daily life. Continuous monitoring and evaluation are essential to continually enhance the program's effectiveness. Additionally, providing more supportive resources, such as books, access to literature, and in-depth training for educators, is necessary to elevate the program's quality.Consequently, this community service program has brought about significant positive impacts by enhancing the critical thinking skills, speaking abilities, and argumentation skills of high school students, preparing them to face future challenges.
OPTIMALISASI APLIKASI CANVA DALAM UPAYA MENINGKATKAN UMKM
Authors: Febiansa Kevin Zentha , Yuniarti Tatik , Fakhran Al Ramadhan Muhammad
Published: January 2024

One of the skills that is needed for entrepreneurship is making a logo design to support entrepreneurial activities. Therefore, there is a need for training to improve the ability and creativity of individuals who want to become entrepreneurs. The purpose of this community service is to provide knowledge and skills to the community, especially the young people of Setiajaya Village, so that they are able to use the Canva editing application. The training materials that will be provided include presentation of material on how to use the Canva application in creating designs that are used for purposes such as making logos, promotional flyers and business product designs. The method used in this community service activity is providing training material through presentations and using the Canva editing application. The form of achievement from this community service activity is that training can be carried out on the use of the Canva editing application with a maximum number of participants of 20 participants who can take part in the training until the end of the event and it is hoped that participants will gain knowledge about using the Canva design application to improve the skills and creativity of young village children Setiajaya to start entrepreneurship.
SOSIALISASI PEMAHAMAN DAN PENDAMPINGAN PEMBUATAN IZIN USAHA UMKM DESA SUMBERSARI
Authors: Mutmainah Latifah , Juliandara Luthpiyah , Iskandar Tatang
Published: January 2024

The Implementation of community service aims to provide Understanding and assistance in training for the creation of licensed integrated bussiness OSS managed by the goverment in the coordination of invesment services and one-step integrated services (DPMPTSP) aimed at NIB benefits and stucturing administrative order. The method used in research is socialization through lectures, discussion between participants and practice. The conseling approach is semi-formal and relevant according to community needs as well as stuctured explanation in language that is easy to understand. Apart from that , the sources are appropriate to their field of expertise because they are members who are sent directly by the goverment agency that works in the village. The couseling is presented interactively and includes a question and answer session. The result obtained bring benefits and insight to the local community and MSMEs as well as a reference for readers or writers with the subtitle regarding counseling on making bussiness permits (NIB).
Deontic Modality in "The Invisible Man" Movie (A Systemic Functional Linguistics Perspective)
Authors: Muhtar Dian Arnhy , Amstrong Neil
Published: January 2024

This research discusses the aspects of action and speech that are contained in The Invisible Man movie based on the theory of Jespersen and Palmer (2007) in the sub-categories commissive, directive, and volitive. The objective of this research is to describe deontic modality in three sub-categories commissive, directive, and volitive in The Invisible Man movie. This research used the descriptive qualitative method. The sources of data of this research are audio visual as primary data and written utterances from screenshotting and transcribing as secondary data. The data is from The Invisible Man movie. Data collection was carried out by searching and downloading movies, watching movies, screenshotting, classifying, and coding. Data were analyzed by presenting, describing, interpreting, and concluding data to answer research questions from this research. The results show that 18 data are included in the sub-categories commissive, directive, and volitive. Deontic modality appears because it is made by several characters in the movie that make promises and threats (commissive), make requests, order others to do something, give suggestions, carry out obligations (directive), and hope for something (volitive). The researcher found that the characters in The Invisible Man movie adopt deontic modality aspects that focus on the sub-categories commissive, directive, and volitive modality because many scenes show how aspects of the three sub-categories are used by characters to overcome existing problems. These three sub-categories are related to each other, the existence of a commissive that will lead to the directive to volitive.
Account in "Death on the Nile" Movie (A Discourse Analysis)
Authors: Wulandari Sri , Masri Fina Amalia
Published: January 2024

This research discusses the aspects of action that contain accounts in Death on the Nile movie, based on the theory of Scott and Lyman (1968) on the aspect of excuses and justification. The objective of this research is to describe the types of accounts in Death on the Nile movie. The researcher used a descriptive qualitative research method. The data sources in this research are divided into two categories, namely movies as primary data and audiovisual as secondary data. Data collection was carried out by downloading movies, watching movies, reading intensively, and selecting data based on the communicative action model. The data was analyzed by presenting, describing, interpreting, and concluding data to answer the research question from this research. The result of the research shows that there are 14 data accounts in Death on the Nile movie. This account occurs because it was created by several characters in the movie who provide excuses and justifications to avoid being accused of the murder incident of a wealthy woman named Linnet. Findings, the researcher found that all justifications are excuses, but not all excuses are justifications. In addition, the justification aspect is more dominant used to justify bad behavior, in the excuses aspect the type of appeal to defeasibility can be used to kill the victim, the appeal to accident aspect is used to make unexpected events, and the appeal to biological aspect is the last aspect that causes behavior. There is no scapegoating aspect in this movie.
Language of Trust in "Raya and The Last Dragon" Movie (A Discourse Analysis)
Authors: Alim Alim
Published: January 2024

This research discusses the language of trust in Raya and the Last Dragon movie based on the trust-repair discourse model established by Fuoli and Paradis. This research aims to describe trust-repair discourse in Raya and the Last Dragon movie. This research used a descriptive qualitative method. The sources of data in this research are divided into two categories namely movies as primary data and audiovisual sources as secondary data. The data was collected through downloading the movie, watching the movie, reading intensively, and selecting the data, based on communicative action models of Fuoli and Paradis. The data was analyzed by presenting, describing, interpreting, and concluding the data to answer the research question of this research. The result shows that there were 10  data Raya and Sisu in the movie suffers from trust-repair. There are two reasons to trigger Raya's broken trust. Her friend betrays her. Her friend and her people try to steal her village’s gem. In this Raya makes her start hard to trust anyone else. She fears something terrible that can happen to Sisu. Therefore, she never trusts other people around her. Sisu sees this. Sisu thinks that such a broken trust will make Raya in trouble. Finally, Sisu tries hard to teach Raya to trust other people. Sisu uses restore neutralizing the negative and emphasizing the positive. They eventually succeed in building Raya’s trust in others.
Kommunernas lägesbildsrapportering under Covid-19 pandemin: Ett medel för regional samverkan eller statlig styrning?
Authors: Järnland Erik , Garcia Fredrik , Wihlborg Elin
Published: January 2024

Den globala Corona-pandemin vände upp och ner på mycket i världen och vi lärde oss att leva tillsammans på nya sätt. Hanteringen av covid-19 viruset och den påföljande pandemin var en gemensam global angelägenhet. Men alla de åtgärder som gjorts i vardagen för att bromsa spridningen och minska konsekvenserna var en lokal och regional angelägenhet. I Sverige och Norden har de lokala och regionala demokratiska sammanslutningarna stort självbestämmande och självstyre. I en kris krävs det att de självstyrande enheterna koordineras och samverkar på bra sätt. Därför är det angeläget att analysera hur sådan koordinering och samverkan gått till för att lära oss till kommande kriser. I den här rapporten beskrivs hur samordningen av kommuners pandemihantering skett genom att studera de lagstadgade styrmedlen – lägesbilder. Lägesbilder är ett sätt att beskriva vad som sker kontinuerligt och genom att dela och jämföra dessa är avsikten att skapa möjligheter till bättre styrning och samordning av krishanteringen. Rapporten är huvudsakligen empirisk och materialet samlades främst in under hösten 2022. Förste författaren Erik Järnland var under den perioden praktikant i forskargruppen och har sedan följt upp och skrivit samman rapporten under hösten 2023 då han arbetade som forskningsassistent. Dessa beskrivningar, som tyvärr tyder på att krishanteringen inte blev så samordnad och att lägesbilderna inte hade den avsedda effekten, kommer fortsatt att analyseras i vetenskapliga artiklar. Vi vill här rikta ett stort tack till alla dem som bidragit till att ta fram material och delta i intervjuer kring lägesbilderna. Främst vill vi tack de noggranna och hjälpsamma personer som håller i kommunala och regionala diarium och arkiv. Därtill uppskattar vi att de som arbetar strategiskt med krishantering har ställt upp för intervjuer och uppföljande samtal. Vi hoppas att våra sammanställningar här kan komma till nytta för er och era kollegor. Den här rapporten utgör en del av det mångvetenskapliga forskningsprojektet POLYGOV, https://www.polygov.org/. POLYGOV finansieras av Norges Forskningsråd och leds av Are Vegard Haug vid Oslo Met universitet. Projektet syftar till att kartlägga och jämföra krishantering och lokal demokrati i de nordiska länderna under Coronapandemin. I projektet medverkar forskare från nio universitet i Norge, Danmark (inkl Grönland), Sverige, Finland, Island och Färöarna. Forskargruppen vid Avdelningen för statsvetenskap på Linköpings universitet har ansvarat för de svenska delstudierna inom projektet och denna rapport är en del av det. Linköping i december 2023, Elin Wihlborg Professor och forskningsledare
Smoltification, seawater performance, and maturation in Atlantic salmon (Salmo salar) fed different fat levels
Authors: Mota Vasco C. , Verstege Gerhardus C. , Striberny Anja , Lutfi Esmail , Dessen Jens-Erik , Sveen Lene , Burgerhout Erik , Bou Marta
Published: January 2024

Introduction

The use of recirculating aquaculture systems (RAS) to produce Atlantic salmon smolts has resulted in exceptionally high fish growth rates. However, there are potential negative trade-offs between fast growth and key physiological processes, such as inadequate smoltification and early sexual maturation, which can both be linked to body energy reserves.

Methods

This study determined the effect of i) dietary fat levels on Atlantic salmon whole-body fat and fatty acids composition, growth performance and smoltification and ii) a previous dietary regime on seawater growth performance and male early sexual maturation. In freshwater RAS, salmon parr (~19g) were fed 3 fat levels (20, 24, and 28%) over a 14-week period at 12°C. Subsequently, in seawater flow-through systems, smolt (~96g) were fed a control diet (26%) for 12 weeks at 2 temperatures (12 and 16°C).

Results

Dietary fat levels resulted in differences in k-factor, fish whole-body fat and fatty acids composition; the low fat diet resulted in fish with a 23% lower whole-body fat when compared to the other two dietary groups at the end of the freshwater phase. These differences in whole-body fat faded at the end of the seawater phase. During the freshwater phase, all three feeds resulted in a comparable growth performance and smoltification indicator values, including k-factor, gill Na+, K+-ATPase, blood serum chloride and smolt index score. In contrast, water temperature resulted in fish body weight differences, where groups reared at 16°C were larger than those reared at 12°C. Nevertheless, both temperature regimes supported a similar thermal growth coefficient. Smolts grown at 16°C showed a higher level of the sex steroids androstenedione compared to those at 12°C. However, 11-ketotestosterone and testosterone levels did not differ despite a trend for higher levels at 16°C. Furthermore, testis histology at the final sampling indicated that some individuals showed initial signs of maturation (stage 3).

Discussion

In conclusion, varying dietary fat levels (20 - 28%) during the freshwater phase did not influence smoltification or male early sexual maturation during the subsequent grow-out phase. However, a temperature increase from 12 to 16°C resulted in larger fish and appeared to stimulate early male maturation in some fish individuals.
The highs and lows of lifting loads: SPM analysis of multi-segmental spine angles in healthy adults during manual handling with increased load
Authors: Proud Jasmine K. , Garofolini Alessandro , Mudie Kurt L. , Lai Daniel T. H. , Begg Rezaul K.
Published: January 2024

Introduction: Manual handling personnel and those performing manual handling tasks in non-traditional manual handling industries continue to suffer debilitating and costly workplace injuries. Smart assistive devices are one solution to reducing musculoskeletal back injuries. Devices that provide targeted assistance need to be able to predict when and where to provide augmentation via predictive algorithms trained on functional datasets. The aim of this study was to describe how an increase in load impacts spine kinematics during a ground-to-platform manual handling task.

Methods: Twenty-nine participants performed ground-to-platform lifts for six standardised loading conditions (50%, 60%, 70%, 80%, 90%, and 100% of maximum lift capacity). Six thoracic and lumbar spine segments were measured using inertial measurement units that were processed using an attitude-heading-reference filter and normalised to the duration of the lift. The lift was divided into four phases weight-acceptance, standing, lift-to-height and place-on-platform. Statistical significance of sagittal angles from the six spine segments were identified through statistical parametric mapping one-way analysis of variance with repeated measures and post hoc paired t-tests.

Results: Two regions of interest were identified during a period of peak flexion and a period of peak extension. There was a significant increase in spine range of motion and peak extension angle for all spine segments when the load conditions were increased (p < 0.001). There was a decrease in spine angles (more flexion) during the weight acceptance to standing phase at the upper thoracic to upper lumbar spine segments for some condition comparisons. A significant increase in spine angles (more extension) during the place-on-platform phase was seen in all spine segments when comparing heavy loads (>80% maximum lift capacity, inclusive) to light loads (<80% maximum lift capacity) (p < 0.001).

Discussion: The 50%–70% maximum lift capacity conditions being significantly different from heavier load conditions is representative that the kinematics of a lift do change consistently when a participant’s load is increased. The understanding of how changes in loading are reflected in spine angles could inform the design of targeted assistance devices that can predict where and when in a task assistance may be needed, possibly reducing instances of back injuries in manual handling personnel.
Performance of 3D printed porous polyetheretherketone composite scaffolds combined with nano-hydroxyapatite/carbon fiber in bone tissue engineering: a biological evaluation
Authors: Mi Lian , Li Feng , Xu Dian , Liu Jian , Li Jian , Zhong Lingmei , Liu Yanshan , Bai Na
Published: January 2024

Polyetheretherketone (PEEK) has been one of the most promising materials in bone tissue engineering in recent years, with characteristics such as biosafety, corrosion resistance, and wear resistance. However, the weak bioactivity of PEEK leads to its poor integration with bone tissues, restricting its application in biomedical fields. This research effectively fabricated composite porous scaffolds using a combination of PEEK, nano-hydroxyapatite (nHA), and carbon fiber (CF) by the process of fused deposition molding (FDM). The experimental study aimed to assess the impact of varying concentrations of nHA and CF on the biological performance of scaffolds. The incorporation of 10% CF has been shown to enhance the overall mechanical characteristics of composite PEEK scaffolds, including increased tensile strength and improved mechanical strength. Additionally, the addition of 20% nHA resulted in a significant increase in the surface roughness of the scaffolds. The high hydrophilicity of the PEEK composite scaffolds facilitated the in vitro inoculation of MC3T3-E1 cells. The findings of the study demonstrated that the inclusion of 20% nHA and 10% CF in the scaffolds resulted in improved cell attachment and proliferation compared to other scaffolds. This suggests that the incorporation of 20% nHA and 10% CF positively influenced the properties of the scaffolds, potentially facilitating bone regeneration. In vitro biocompatibility experiments showed that PEEK composite scaffolds have good biosafety. The investigation on osteoblast differentiation revealed that the intensity of calcium nodule staining intensified, along with an increase in the expression of osteoblast transcription factors and alkaline phosphatase activities. These findings suggest that scaffolds containing 20% nHA and 10% CF have favorable properties for bone induction. Hence, the integration of porous PEEK composite scaffolds with nHA and CF presents a promising avenue for the restoration of bone defects using materials in the field of bone tissue engineering.
The application of custom 3D-printed prostheses with ultra-short stems in the reconstruction of bone defects: a single center analysis
Authors: Zhang Peng , Tian Wen , Li Po , Zhang Fan , Qu Guoxin , Du Xinhui , Liu Guancong , Niu Xiaoying
Published: January 2024

Objective: Considering the advantages and widespread presence of 3D-printing technology in surgical treatments, 3D-printed porous structure prostheses have been applied in a wide range of the treatments of bone tumor. In this research, we aimed to assess the application values of the 3D-printed custom prostheses with ultra-short stems for restoring bone defects and maintaining arthrosis in malignant bone tumors of lower extremities in children.

Methods: Seven cases of pediatric patients were included in this study. In all cases, the prostheses were porous titanium alloy with ultra-short stems. MSTS 93 (Musculoskeletal Tumor Society) scores were recorded for the functional recovery of the limbs. VAS (Visual analogue scale) scores were utilized to assess the degree of painfulness for the patients. X-ray and MRI (magnetic resonance imaging) were applied to evaluate the bone integration, prostheses aseptic loosening, prostheses fracture, wound healing, and tumor recurrence during follow-up.

Results: During follow-up, none of the patients developed any postoperative complications, including prostheses aseptic loosening, prostheses fracture, or tumor recurrence. Radiological examinations during the follow-up showed that prostheses implanted into the residual bone were stably fitted and bone defects were effectively reconstructed. The MSTS 93 scores were 24.9 ± 2.9 (20–28). VAS scores were decreased to 5.8 ± 1.2 (4.0–7.0). No statistically significant differences in leg length discrepancy were observed at the time of the last follow-up.

Conclusion: 3D-printing technology can be effectively applied throughout the entire surgical treatment procedures of malignant bone tumors, offering stable foundations for the initial stability of 3D-printed prostheses with ultra-short stems through preoperative design, intraoperative precision operation, and personalized prosthesis matching. With meticulous postoperative follow-up, close monitoring of postoperative complications was ensured. These favorable outcomes indicate that the utilization of 3D-printed custom prostheses with ultra-short stems is a viable alternative for reconstructing bone defects. However, further investigation is warranted to determine the long-term effectiveness of the 3D-printing technique.
Study on earthquake and tsunami hazard: evaluating probabilistic seismic hazard function (PSHF) and potential tsunami height simulation in the coastal cities of Sumatra Island
Authors: Triyoso Wahyu , Kongko Widjo , Prasetya Gegar S. , Suwondo Aris
Published: January 2024

This study uses integrated geological, geodesy, and seismology data to assess the potential tsunami and Probabilistic Seismic Hazard Function (PSHF) near Sumatra’s coastal cities. It focuses on estimating the possible level of ground shaking due to the seismic activity within the Sumatran Fault Zone (SFZ) and subduction zone. It uses the Peak Ground Acceleration (PGA) as a measure. An amplification factor that is based on the previous study is used. It is calculated through the Horizontal-Vertical Spectral Ratio (HVSR), which measures possible surface ground shaking. The Seismic Hazard Function (SHF) is calculated considering magnitudes 6.5 to 9.0 for subduction sources and 6.5 to 7.8 for SFZ sources. Also, the PGA based on the Maximum Possible Earthquake (MPE) magnitude is estimated, and tsunami heights are simulated to assess the possible hazard risk. The tsunami source model in this study is characterized by considering the possibility of the long-term perspectives on giant earthquakes and tsunamis that might occur in subduction zones around the off-coast of southern Sumatra Island. The potentiality source zone is characterized based on the utilization of the cross-correlation of correlation dimension (DC) based on the shallow earthquake catalog of 2010 to 2022 and the SHmax-rate of surface strain rate. Based on the MPE, the relatively high estimated PGA at the base rock was found around Mentawai and Pagai Utara islands at about 0.224 g and 0.328 g, with the largest estimated PGA based on the MPE at the surface with values of about 0.5 g and 0.6 g. The possible maximum tsunami height (Hmax) estimated based on source scenarios position around the west coast of Sumatera Island, such as for Kota Padang and Kota Bungus, reaches up to 12.0 m and 22.0 m, respectively. The findings provide valuable insight into seismic and tsunami hazards, benefiting future mitigation strategies.
Fumarate respiration of Fasciola flukes as a potential drug target
Authors: Tashibu Atsushi , Inaoka Daniel Ken , Sakamoto Kimitoshi , Murakami Kenji , Zannatul Ferdoush , Kita Kiyoshi , Ichikawa-Seki Madoka
Published: January 2024

Fascioliasis is a neglected tropical zoonotic disease caused by liver flukes belonging to the genus Fasciola. The emergence of resistance to triclabendazole, the only World Health Organization-recommended drug for this disease, highlights the need for the development of new drugs. Helminths possess an anaerobic mitochondrial respiratory chain (fumarate respiration) which is considered a potential drug target. This study aimed to evaluate the occurrence of fumarate respiration in Fasciola flukes. We analyzed the properties of the respiratory chain of Fasciola flukes in both adults and newly excysted juveniles (NEJs). Fasciola flukes travel and mature through the stomach, bowel, and abdominal cavity to the liver, where oxygen levels gradually decline. High fumarate reductase activity was observed in the mitochondrial fraction of adult Fasciola flukes. Furthermore, rhodoquinone-10 (RQ10 Em’= −63 mV), a low-potential electron mediator used in fumarate respiration was found to be predominant in adults. In contrast, the activity of oxygen respiration was low in adults. Rotenone, atpenin A5, and ascochlorin, typical inhibitors of mitochondrial enzymes in complexes I, II, and III, respectively, inhibit the activity of each enzyme in the adult mitochondrial fraction. These inhibitors were then used for in vitro viability tests of NEJs. Under aerobic conditions, NEJs were killed by rotenone or ascochlorin, which inhibit aerobic respiration (complex I–III), whereas atpenin A5, which inhibits complex II involved in fumarate respiration, did not affect NEJs. Moreover, ubiquinone-10 (UQ10 Em’= +110 mV), which is used in oxidative respiration, was detected in NEJs, in addition to RQ10. In contrast, under anaerobic conditions, rotenone and atpenin A5, which inhibit fumarate respiration (complex I–II), were crucial for NEJs. These findings demonstrate that NEJs have active hybrid respiration, in which they can properly use both oxygen and fumarate respiration, depending on oxygen availability. Thus, fumarate respiration is a promising drug target for Fasciola flukes, because it plays an essential role in both adults and NEJs.
In vitro inhibition of biofilm and virulence factor production in azole-resistant strains of Candida albicans isolated from diabetic foot by Artemisia vulgaris stabilized tin (IV) oxide nanoparticles
Authors: Zubair Mohammad , Husain Fohad Mabood , Al-Amri Marai , Hasan Imran , Hassan Iftekhar , Albalawi Thamer , Fatima Farha , Khan Altaf , Arshad Mohammed , Alam Pravej , Ahmad Naved , Alatawy Roba , Begum Shamina , Mir Rashid , Alshadfan Hisham , Ansari Abid Ali , Al-Anazi Abeer Bader Abdi Al-faqir
Published: January 2024

The advent of nanotechnology has been instrumental in the development of new drugs with novel targets. Recently, metallic nanoparticles have emerged as potential candidates to combat the threat of drug-resistant infections. Diabetic foot ulcers (DFUs) are one of the dreadful complications of diabetes mellitus due to the colonization of numerous drug-resistant pathogenic microbes leading to biofilm formation. Biofilms are difficult to treat due to limited penetration and non-specificity of drugs. Therefore, in the current investigation, SnO2 nanoparticles were biosynthesized using Artemisia vulgaris (AvTO-NPs) as a stabilizing agent and were characterized using ultraviolet–visible (UV–vis) spectroscopy, Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), scanning electron microscopy (SEM), and energy-dispersive X-ray spectroscopy (EDX). Furthermore, the efficacy of AvTO-NPs against biofilms and virulence factors of drug-resistant Candida albicans strains isolated from DFUs was assessed. AvTO-NPs displayed minimum inhibitory concentrations (MICs) ranging from 1 mg/mL to 2 mg/mL against four strains of C. albicans. AvTO-NPs significantly inhibited biofilm formation by 54.8%–87%, germ tube formation by 72%–90%, cell surface hydrophobicity by 68.2%–82.8%, and exopolysaccharide (EPS) production by 69%–86.3% in the test strains at respective 1/2xMIC. Biosynthesized NPs were effective in disrupting established mature biofilms of test strains significantly. Elevated levels of reactive oxygen species (ROS) generation in the AvTO-NPs-treated C. albicans could be the possible cause of cell death leading to biofilm inhibition. The useful insights of the present study could be exploited in the current line of treatment to mitigate the threat of biofilm-related persistent DFUs and expedite wound healing.
Genome-wide transcriptome analysis of Echinococcus multilocularis larvae and germinative cell cultures reveals genes involved in parasite stem cell function
Authors: Herz Michaela , Zarowiecki Magdalena , Wessels Leonie , Pätzel Katharina , Herrmann Ruth , Braun Christiane , Holroyd Nancy , Huckvale Thomas , Bergmann Monika , Spiliotis Markus , Koziol Uriel , Berriman Matthew , Brehm Klaus
Published: January 2024

The lethal zoonosis alveolar echinococcosis is caused by tumour-like growth of the metacestode stage of the tapeworm Echinococcus multilocularis within host organs. We previously demonstrated that metacestode proliferation is exclusively driven by somatic stem cells (germinative cells), which are the only mitotically active parasite cells that give rise to all differentiated cell types. The Echinococcus gene repertoire required for germinative cell maintenance and differentiation has not been characterised so far. We herein carried out Illumina sequencing on cDNA from Echinococcus metacestode vesicles, from metacestode tissue depleted of germinative cells, and from Echinococcus primary cell cultures. We identified a set of ~1,180 genes associated with germinative cells, which contained numerous known stem cell markers alongside genes involved in replication, cell cycle regulation, mitosis, meiosis, epigenetic modification, and nucleotide metabolism. Interestingly, we also identified 44 stem cell associated transcription factors that are likely involved in regulating germinative cell differentiation and/or pluripotency. By in situ hybridization and pulse-chase experiments, we also found a new general Echinococcus stem cell marker, EmCIP2Ah, and we provide evidence implying the presence of a slow cycling stem cell sub-population expressing the extracellular matrix factor Emkal1. RNA-Seq analyses on primary cell cultures revealed that metacestode-derived Echinococcus stem cells display an expanded differentiation capability and do not only form differentiated cell types of the metacestode, but also cells expressing genes specific for protoscoleces, adult worms, and oncospheres, including an ortholog of the schistosome praziquantel target, EmTRPMPZQ. Finally, we show that primary cell cultures contain a cell population expressing an ortholog of the tumour necrosis factor α receptor family and that mammalian TNFα accelerates the development of metacestode vesicles from germinative cells. Taken together, our analyses provide a robust and comprehensive characterization of the Echinococcus germinative cell transcriptome, demonstrate expanded differentiation capability of metacestode derived stem cells, and underscore the potential of primary germinative cell cultures to investigate developmental processes of the parasite. These data are relevant for studies into the role of Echinococcus stem cells in parasite development and will facilitate the design of anti-parasitic drugs that specifically act on the parasite germinative cell compartment.
Study on deformation characteristics of underground pipeline corridors and uneven settlement factors of foundations in sandy chalky soil layer
Authors: Zhang Yulong , Duan Lincheng , Li Yuanxiang , Gao Meiben
Published: January 2024

Uneven settlement phenomenon is very easy to occur in the sandy pulverized ground stratum, the underground pipe corridor longitudinal and transverse stiffness difference is obvious, so that it is easy to crack and deformation due to uneven settlement in this type of stratum. This paper carries out research on uneven settlement and cracking and deformation of Qihe tube corridor, analyzes the reasons leading to uneven settlement and the factors affecting the deformation and cracking of the tube corridor, and provides guidance for foundation treatment and tube corridor repair and mixing and reinforcement. It was found that the concrete structure of the corridor itself had exposed reinforcement, pockmarks and holes, and that cracks on the structure of the corridor sprouted and expanded from these defects. Defects and damages on the concrete structure of the pipeline corridor are contributing factors to the deformation and cracking of the members, and the uneven settlement of the foundation is the main initiating factor for the cracking and deformation. The analysis of the numerical simulation results of similar underground pipeline corridors is carried out, and it is found that the simulation results are consistent with the deformation characteristics of the Qihe pipeline corridor, which further supports the conclusions of this paper. The main stratigraphic factors contributing to the inhomogeneous settlement were found to be the water-rich and loose bodies in the lower part of the strata, as revealed by the physical means and the experimental verification boreholes. Localized hydraulic effects such as pumping further accelerate the uneven settlement of the foundation.