bluuebunny/crossref_metadata_2025 huggingface dataset:
Perceptions of cancer prevention options for Lynch syndrome (LS) in a multi-national convenience sample.
Authors: Hall Michael J. , Singhal Sachi , Osorio Nadine , Chavez Juan Pablo , Riggs Emma D. , Chertock Yana , Daly Mary Beryl
Published: January 2024

77

Background: LS is among the most common cancer (CA) syndromes affecting 1:280 individuals and portends high lifetime CA risk. Clinical trials are currently evaluating whether frameshift peptide vaccination (FSPVAX) could reduce LS CA risk. FSPVAX enhances immune response to diverse FSP neoantigens in MSI-H tumors and has shown promising results in an MSH2-mutant mouse model and metastatic MSI-H CRC. However, negative public attitudes towards vaccination and evidence suggesting low uptake of ASA chemoprevention (CP) among patients with LS could undermine success of this novel therapy. Here, we benchmark attitudes towards FSPVAX for CA prevention against colonoscopy (COLO) and aspirin or NSAID chemoprevention (CP). Methods: The PREVENTLynchII survey (IRB 20-8014) was distributed electronically to 1) participants in the Fox Chase Cancer Center (FCCC) Risk Registry and 2) members of two online LS support groups. Patients were invited to complete the one-time survey after providing informed consent. Demographic and personal CA history were collected. Attitudes were measured on 9-point scales indicating low vs high agreement with belief statements: e.g. “Colonoscopy is a convenient way to lower my risk of LS-related CA.” Results: Overall 296 participants at FCCC, nationally, and internationally completed the survey. Median age was 52.6 years [23-78], 84% female, and 95% White. Affected genes included MLH1 (20.3%), MSH2/EPCAM (35.5%), MSH6 (28.7%), and PMS2 (15.5%). Use of CP was uncommon (32.1% and 5.1% respectively). Stratified analyses of COLO perceptions by sex, age, and personal history of CA showed no differences. Interestingly, US pts viewed ASA as more convenient than non-US, and with lower risk of side effects (p=0.007), but were no more likely to use or recommend CP. Compared to COLO, FSPVAX was overall viewed as more convenient, but side effect concerns were higher, and perceptions of efficacy were lower (all p<0.001), while compared to CP, FSPVAX was less convenient and fostered greater concerns about side effects, but was viewed as having higher potential preventive efficacy (all p<0.001). FSPVAX perceptions showed high variability: pts >50 (p=0.003) and CA pts (p=0.01) saw FSP as more convenient (p=0.003) than younger and unaffected pts. CA pts reported higher reassurance than unaffected (p=0.04), while those >50 were more likely to participate in an FSPVAX study (p=0.04). US pts perceived more side effect risk of FSPVAX than non-US (p=0.003). Conclusions: Concerns about ASA CP and FSPVAX convenience, side effects, and efficacy are common among US and international patients with LS. [Table: see text]
Retrospective review of compliance with guideline-directed germline testing in microsatellite instability-high colorectal cancer treated at the Veterans Health Administration.
Authors: Williams Silva Karly , Cohen Stacey A. , Frias Kletecka M. Carmen , Ioannou George , Aslan Deniz , Becker Daniel Jacob , Kenny Avi , Montgomery Robert Bruce
Published: January 2024

86

Background: Lynch syndrome (LS) is an autosomal dominant inherited cancer syndrome that confers an increased risk of colorectal cancer (CRC). As clinical and history features under-recognize LS cases (3-5% of CRC), universal screening of CRCs for LS is recommended. Patients whose CRCs are mismatch repair protein deficient (dMMR) and/or microsatellite instability high (MSI-H) are recommended to have subsequent genetics evaluation to screen for germline mutations. Confirmed LS changes cancer surveillance recommendations for affected patients and their relatives. Within Veterans Health Administration (VHA), GT is ordered by genetic counselors at genomic medicine telehealth centers (GMTC), after initial consultation. We aim to quantify rates at which CRC patients treated at the VHA complete germline testing (GT) when indicated. Methods: The electronic health records (EHRs) of VHA patients with known dMMR/MSI-H CRC were reviewed. Cases were extracted from both Veterans Affairs (VA) Puget Sound and referral VA MSI testing laboratories. Surgical pathology reports and clinical documentation were reviewed in Joint Longitudinal Viewer (JLV) to determine if GT was indicated and reason for non-testing, if not performed. Patients with known LS prior to development of CRC were excluded, and patients with dMMR in MLH1 or MSI-H with concurrent BRAFV600 mutation and/or MLH1 hypermethylation were considered to have sporadic CRC. Results: Of 110 patients with abnormal tumor LS screening; 39 (36%) patients’ tumor tissue underwent IHC for dMMR, 16 (14%) underwent PCR for MSI, and 55 (50%) had both. 45 (41%) patients were classified as somatic MSI-H. 65 (59%) patients met criteria for referral for GMTC and GT. Of these 65, 49 ultimately did not undergo GT and 16 did, which confirmed 4 cases of LS and revealed 1 variant of uncertain significance in the MLH1 gene. Reasons for non-testing were: 7 (14%) declined all cancer testing and treatment after CRC diagnosis or were lost to follow-up/declined establishment of cancer care, 3 (6%) declined referral to GMTC, 14 (29%) accepted referral to GMTC but never had consultation, 7 (14%) accepted referral to GMTC but declined GT when offered, and 18 (37%) were never offered GMTC referral or GT. Conclusions: A majority of dMMR/MSI-H cases with an indication for GT were referred for genetic counseling, but only a small subset completed testing. This analysis identified multiple areas for improvement, including a lack of recognition by providers for the need for GT, and lack of completion of testing by patients at multiple levels. Further evaluation of VHA-specific barriers is needed to improve the quality of delivered care.
Safety and efficacy of ONO-4578 plus nivolumab in metastatic colorectal cancer.
Authors: Kawazoe Akihito , Takashima Atsuo , Matsuoka Hiroshi , Hamamoto Yasuo , Okuno Tatsuya , Hamaguchi Tetsuya , Yamaguchi Kensei , Oki Eiji , Sugimoto Naotoshi , Tsuji Yasushi , Boku Shogen , Nishina Tomohiro
Published: January 2024

93

Background: The prostaglandin E2-EP4 signaling is involved in immunosuppression in cancers. In the dose escalation part of the ONO-4578-01, open-label, uncontrolled phase 1 study, ONO-4578, an EP4 antagonist, plus nivolumab (4578+NIV) demonstrated manageable safety profile and antitumor activities in metastatic or advanced solid tumors. CRC cohort assessed safety, preliminary efficacy, and biomarkers of 4578+NIV in patients with metastatic colorectal cancer (mCRC). Methods: The CRC cohort was conducted at 12 sites in Japan and it included patients aged ≥20 years with mCRC; those with microsatellite-instability-high, deficient mismatch repair, or BRAF mutations were excluded. The optimal dose was determined based on the results of dose escalation part of ONO-4578-01. Patients received oral ONO-4578 (40 mg, daily) and intravenous nivolumab (480 mg, every 4 weeks) in 28-day cycles. The primary endpoint was safety. Exploratory endpoints included efficacy and biomarkers. Results: A total of 51 patients were enrolled: 24 (47.1%) were male and the median age was 59.0 (range, 33–79) years. Adverse events (AEs) occurred in 48 patients (94.1%), wherein grade 3–4 AEs occurred in 23 (45.1%). No patients died due to AEs. Serious AEs occurred in 11 (21.6%) patients. The most common AEs of any grade were rash (33.3%) and anemia (31.4%). Any-grade and grade ≥3 treatment-related AEs (TRAEs) occurred in 36 (70.6%) and 13 (25.5%) patients, respectively. Two patients achieved partial response and 18 had stable disease; the objective response rate was 3.9% (90% confidence interval [CI], 0.7–11.8) and the disease control rate was 39.2% (90% CI, 27.7–51.7). The median progression-free survival and overall survival (OS) were 1.54 (90% CI, 1.41–2.79) and 10.68 months (90% CI, 6.67–not reached [NR]), respectively. The proportion of patients continuing treatment and OS in subgroups of different PD-L1 combined positive scores (CPS) showed a tendency toward favorable efficacy in CPS-positive subgroups: the proportion of patients continuing treatment for 6 months was 4.5% (1/22) in those with CPS of 0 vs 20% (5/25) in those with CPS ≥1, and the median OS was 9.4 months (90% CI, 5.65–12.06) in those with CPS of 0 vs NR (90% CI, 10.41–NR) in those with CPS ≥1. Conclusions: 4578+NIV showed an acceptable safety profile in patients with mCRC, and no new safety signals were detected. 4578+NIV also showed antitumor activity in patients with mCRC. Favorable efficacy was observed in the PD-L1 CPS-positive subpopulation. Clinical trial information: jRCT2080223441 .
FOLFOXIRI ± molecular targeting agent (bevacizumab or panitumumab) for conversion from unresectable to resectable in the advanced/recurrent colorectal cancer.
Authors: Takemori Kodai , Kobayashi Kazuma , Inoue Yusuke , Okada Satomi , Adachi Toshiyuki , Soyama Akihiko , Adachi Tomohiko , Kanetaka Kengo , Eguchi Susumu
Published: January 2024

99

Background: As treatment for unresectable advanced/recurrent colorectal cancer (ARCC), the introduction of doublet chemotherapy, represented by FOLFOX/FOLFIRI, and molecular-targeting agents, such as anti-VEGF antibody and anti-EGFR antibody, has given ARCC patients a more than three years’ survival. Triplet chemotherapy, such as FOLFOXIRI ± Bevacizumab or Panitumumab, has already been used in daily practice. These regimens with powerful anti-tumor effects have enabled conversion from unresectable to resectable, giving patients a longer survival than those without conversion. Therefore, we explored the ideal regimen for conversion, focusing on FOLFOXIRI ± X. Methods: We retrospectively reviewed unresectable ARCC patients treated with FOLFOXIRI ± X (X:Bmab, n=24; Pmab, n=1; alone, n=2; ) between February 2015 and December 2022. The results were compared to those of patients who received other regimens (OTHERS; n=212). Results: The median overall survival (OS) was 1072 days. Forty-nine patients acquired conversion. The patients with conversion had a longer progression-free survival and OS than those without conversion (p<0.0001 and <0.0001, respectively). Conversion rates were 37.0% in FOLFOXIRI ± X vs. 18.4% in OTHERS (p=0.0238), while response rates were 59.3% in FOLFOXIRI ± X vs. 35.8% in OTHERS (p=0.0185). The RAS wild-type group conversion rates were 30.0% in FOLFOXIRI ± X vs. 20.6% in OTHERS, while 50.0% in FOLFOXIRI ± X vs. 15.3% in OTHERS in RAS mutant group. Anti-EGFR antibody +L-OHP-based doublet chemotherapy accounted for conversion in 35.3% of the RAS wild-type group. Anti-VEGF antibody + L-OHP based doublet chemotherapy attained 29.1% conversion rate in RAS mutant group. Molecular targeting agent+doublet or triplet regimens were essential for conversion. FOLFOXIRI ± X achieved a 88.9% disease control rate, with palliation of symptoms due to a high tumor burden in 10 of 13 cases. Conclusions: Based on these results, FOLFOXIRI ± X may be an ideal candidate for achieving conversion in first-line treatment of unresectable ARCC.
Pathological complete response (pCR) to 5-fluorouracil, leucovorin, oxaliplatin and docetaxel (FLOT) with or without durvalumab (D) in resectable gastric and gastroesophageal junction cancer (GC/GEJC): Subgroup analysis by region from the phase 3, randomized, double-blind MATTERHORN study.
Authors: Janjigian Yelena Y. , Al-Batran Salah-Eddin , Wainberg Zev A. , Van Cutsem Eric , Molena Daniela , Muro Kei , Hyung Woo Jin , Wyrwicz Lucjan S. , Oh Do-Youn , Omori Takeshi , Moehler Markus , Garrido Marcelo , Oliveira Sulene CS , Liberman Moishe , Castro Oliden Victor , Bilici Mehmet , Kurland John F. , Xynos Ioannis , Mann Helen , Tabernero Josep
Published: January 2024

LBA246

Background: FLOT was established as a perioperative therapy for GC/GEJC following the Phase 2/3 FLOT4 study conducted in Germany, with a pCR rate of 16% (Al-Batran et al, Lancet Oncol 2016). The global MATTERHORN study (NCT04592913) showed a statistically significant improvement in pCR with perioperative D + FLOT vs placebo (P) + FLOT in GC/GEJC at first interim analysis (Janjigian et al, ESMO Congress 2023). Subgroup analyses by region and country were completed to assess pCR rates with FLOT and benefit of D + FLOT across the global study population. Methods: Participants (pts) with resectable GC/GEJC were randomized 1:1 to D 1500 mg or P every 4 weeks (Q4W) on Day 1 plus FLOT Q2W on Days 1 and 15 for 4 cycles (2 doses of D or P and 4 doses of FLOT pre- and post-operative), followed by D 1500 mg or P on Day 1 Q4W for 10 further cycles. Randomization was stratified by Asia vs non-Asia. pCR (Modified Ryan; central review) was assessed in prespecified (Asia) and post hoc regional subgroups, including 6 countries with the highest numbers of randomized pts. Results: Of 948 pts randomized globally, 180 pts (19%) were in Asia. pCR outcomes with FLOT in Asia were consistent with the global outcomes. pCR rates were improved with D + FLOT vs P + FLOT in all regions (Asia, Europe, North America and South America; Table), despite some imbalances in baseline characteristics and numerical differences in pCR rates by geographic location. The pCR rate with P + FLOT in the German subgroup (13%; 95% CI, 6.1–23.0) was similar to that with FLOT in the FLOT4 study. Improvement in pCR with D + FLOT vs P + FLOT was observed across subgroups by country. Similar trends across regional subgroups were observed for combined complete and near-complete response rate. Conclusions: In MATTERHORN, pCR was consistently improved with the addition of D to perioperative FLOT in GC/GEJC across geographic regions. The study is ongoing for the primary objective of event-free survival. Clinical trial information: NCT04592913 .[Table: see text]
Sequential or up-front triple combination with durvalumab, tremelimumab, and bevacizumab for patients with unresectable hepatocellular carcinoma (HCC): MONTBLANC.
Authors: De Toni Enrico N. , Mayerle Julia , Oehrle Bettina , Seidensticker Max , Rimassa Lorenza , Ehmer Ursula , Geier Andreas , Reiter Florian P , Ettrich Thomas Jens , Philipp Alexander B , Rössler Daniel Christoph , Ben Khaled Najib
Published: January 2024

TPS574

Background: Escalation of treatment from one to two combined immune checkpoint inhibitors (CPI) has dramatically increased objective and clinical response in advanced hepatocellular carcinoma (HCC) patients. Establishing strategies with more than two CPI agents to further increase response while maintaining a manageable toxicity is therefore a top priority. The upfront simultaneous use of three or more CPI can yield a strong initial response to treatment, but it may also increase treatment-related toxicity. An alternative approach, which prioritizes safety over immediate response, involves utilizing different CPI doublets in a sequential manner. However, this design entails switching to a different combination only after radiological progression is observed, and recurrent progressions may lead to deteriorating liver function and treatment resistance. Trials of immunotherapy of HCC conducted in recent years showed that the efficacy of CPI, when used simultaneously, outweighs the drawbacks of their combined toxicity and that early radiological response to treatment, or the lack thereof, is a predictor of clinical outcome. In addition, failure of trials using broad-spectrum tyrosine kinase inhibitors (TKI) and CPI suggest that antibodies or narrow-spectrum TKI should be used for future CPI-based combinations in HCC studies. Based on these considerations, the MONTBLANC study is the first trial to assess the effectiveness of up-front triple treatment with a combination of the three currently approved immunological agents for HCC and to implement the concept of treatment escalation determined by lack of early radiological response (as opposed to treatment progression). Methods: The MONTBLANC study is a randomized, 2-arm phase II study on the efficacy of combinations of durvalumab, tremelimumab, and bevacizumab in patients with advanced HCC. Patients with preserved liver function (Child-Pugh A) with unresectable tumors or not amenable to local or locoregional treatment are randomized to an early escalation arm (A) or a triple treatment arm (B). Patients in arm A receive combined durvalumab and tremelimumab (STRIDE regimen). Treatment is escalated by the addition of bevacizumab upon detection of disease progression or in the absence of radiological response by the 4th month of treatment. Patients in arm B receive up-front STRIDE and bevacizumab. Treatment will continue until unacceptable toxicity or progression under the Bev-containing regimen. The primary endpoint is overall response rate (ORR). Clinical trial information: NCT05844046 .
FusionVAC22_01: A phase I clinical trial evaluating a DNAJB1-PRKACA fusion transcript-based peptide vaccine combined with immune checkpoint inhibition for fibrolamellar hepatocellular carcinoma and other tumor entities carrying the oncogenic driver fusion.
Authors: Bitzer Michael , Hackenbruch Christopher , Bauer Jens , Heitmann Jonas S. , Maringer Yacine , Nelde Annika , Salih Helmut R. , Walz Juliane S.
Published: January 2024

TPS580

Background: The DNAJB1-PRKACA fusion transcript is the driver of tumor pathogenesis in fibrolamellar hepatocellular carcinoma (FL-HCC) as well as in other tumor entities, e.g. oncocytic neoplasms of the pancreas and bile duct, thus representing a broad target for novel therapies in cancer. Recently, the DNAJB1-PRKACA fusion protein was identified as a source for HLA-presented neoepitopes that can be targeted by T-cell-based immunotherapy (Bauer et al. Nat. Commun., 2022). The DNAJB1-PRKACA fusion-derived neoepitope FusionVAC-22 is in silico predicted to bind to 1,290 HLA class II alleles and contains HLA class I ligands from 13 of the 20 most frequent HLA class I alleles that cover 93.8% of the world population with at least one HLA allotype, enabling the broad application of FusionVAC-22-based immunotherapies. The first application of FusionVAC-22-based peptide vaccines adjuvanted with the TLR1/2 agonist XS15 emulsified in Montanide ISA 51 VG in two FL-HCC patients was well tolerated and showed the induction of profound and long-lasting T-cell responses. Of note, T-cell responses were accompanied by progression-free survival of both patients for so far 32 months and 13 months, respectively. Methods: Based on these encouraging results, we established a Phase I open-label, multicentric clinical trial to evaluate the immunogenicity along with safety and toxicity, as well as first signs of efficacy of the FusionVAC-22 based peptide vaccine, combined with the immune checkpoint inhibitor (ICI) atezolizumab, in 20 patients with locally advanced or metastatic FL-HCC or other malignant diseases that carry the DNAJB1-PRKACA fusion transcript. Further, key eligibility criteria include the absence of autoimmune phenomena due to prior immunotherapy agents (≥ grade 3) as well as tissue or organ allografts. The FusionVAC-22-based peptide vaccine is applied twice in a 4-weekly interval with the opportunity of a booster vaccination after 11 months. Atezolizumab application starts on day 15 after first vaccination and is continued 4-weekly for 1 year, followed by a 6-month follow-up. The primary objectives of the trial are immunogenicity, in terms of induction of peptide specific T-cell responses until 28 days after second vaccination, as well as safety and toxicity of the peptide vaccine in combination with ICI. Safety assessment is based on the frequency of adverse events according to CTCAE v5.0. Clinical efficacy is determined by iRECIST assessment on imaging. Furthermore, disease control rate, quality of life as well as overall and progression free survival will be assessed. Clinical trial information: NCT05937295 .
Repeat Flow Diversion for Retreatment of Incompletely Occluded Large Complex Symptomatic Cerebral Aneurysms: A Retrospective Case Series
Authors: Kashkoush Ahmed , El-Abtah Mohamed E. , Davison Mark A. , Toth Gabor , Moore Nina , Bain Mark
Published: January 2024

BACKGROUND AND OBJECTIVES:

Data regarding radiographic occlusion rates after repeat flow diversion after initial placement of a flow diverter (FD) in large intracranial aneurysms are limited. We report clinical and angiographic outcomes on 7 patients who required retreatment with overlapping FDs after initial flow diversion for large intracranial aneurysms.

METHODS:

We performed a retrospective review of a prospectively maintained database of cerebrovascular procedures performed at our institution from 2017 to 2021. We identified patients who underwent retreatment with overlapping FDs for large (>10 mm) cerebral aneurysms after initial flow diversion. At last angiographic follow-up, occlusion grade was evaluated using the O'Kelly-Marotta (OKM) grading scale.

RESULTS:

Seven patients (median age 57 years) with cerebral aneurysms requiring retreatment were identified. The most common aneurysm location was the ophthalmic internal carotid artery (n = 3) and basilar trunk (n = 3). There were 4 fusiform and 3 saccular aneurysms. The median aneurysm width was 18 mm; the median neck size for saccular aneurysms was 7 mm; and the median dome-to-neck ratio was 2.8. The median time to retreatment was 9 months, usually due to symptomatic mass effect. After retreatment, the median clinical follow-up was 36 months, MRI/magnetic resonance angiography follow-up was 15 months, and digital subtraction angiography follow-up was 14 months. Aneurysm occlusion at last angiographic follow-up was graded as OKM A (total filling, n = 1), B (subtotal filling, n = 2), C (early neck remnant, n = 3), and D (no filling, n = 0). All patients with symptomatic improvement were OKM C, whereas patients with worsened symptom burden were OKM A or B. Two patients required further open surgical management for definitive management of the aneurysm remnant.

CONCLUSION:

Although most patients demonstrated a decrease in aneurysm remnant size, many had high-grade persistent filling (OKM grades A or B) in this subset of mostly large fusiform aneurysms. Larger studies with longer follow-up are warranted to optimize treatment strategies for atypical aneurysm remnants after repeat flow diversion.
Design and optical characterization of anisotropic plasmonic metamaterials at visible and infrared wavelengths
Authors: Βασιλαντωνάκης Νικόλαος
Published: January 2024

Το πεδίο της πλασμονικής μελετά την αλληλεπίδραση φωτός και ελεύθερων ηλεκτρονίων στα μέταλλα, που προκαλούν διέγερση επιφανειακών κυμάτων, σε μια μεταλλοδιηλεκτρική διεπιφάνεια. Ένας κλάδος της πλασμονικής είναι ο σχεδιασμός μεταϋλικών σε ορατό και υπέρυθρο φασματικό εύρος, τα οποία είναι τεχνητές δομές σχεδιασμένες να χειρίζονται τη διάδοση του φωτός με τρόπο που δεν είναι δυνατός με τα συμβατικά υλικά. Η παρούσα διπλωματική εργασία χωρίζεται σε 3 κύρια μέρη. Το πρώτο μέρος εξετάζει τα αποτελέσματα των κυματοδηγούμενων τρόπων σε κυματοδηγούς μεταϋλικού Au nanorod. Δείχνει, τόσο θεωρητικά όσο και πειραματικά, ότι αυτά τα υλικά μπορούν να σχεδιαστούν για να ελέγχουν το πρόσημο και το μέγεθος της ταχύτητας της τροπικής ομάδας ανάλογα με τη γεωμετρία και την πόλωση που επιλέχθηκε, παρουσιάζοντας υψηλούς αποτελεσματικούς δείκτες διάθλασης (έως 10) και έχουν μια ασυνήθιστη αποκοπή από την πλευρά της υψηλής συχνότητας, παρέχοντας μονόδρομη καθοδήγηση σε βάθος υπομήκους κύματος (λ_0/6 - λ_0/8 πάχος κυματοδηγού). Αυτό επιτρέπει την ύπαρξη αργού φωτός σε τέτοιους κυματοδηγούς σε ένα ελεγχόμενο περιβάλλον που είναι κρίσιμος παράγοντας για μη γραμμικές και ενεργές νανοφωτονικές συσκευές, κβαντική επεξεργασία πληροφοριών, προσωρινή αποθήκευση και οπτικά στοιχεία αποθήκευσης δεδομένων. Το δεύτερο μέρος συζητά, αναλυτικά και αριθμητικά, στρατηγικές βιοαισθητοποίησης και ενίσχυσης της μη γραμμικότητας με υπερβολικά μεταϋλικά νανοράβδου. Δείχνει πώς μπορεί να βελτιωθεί η ευαισθησία των αδέσμευτων, των διαρροών καθώς και των κυματοδηγούμενων τρόπων με βάση γεωμετρικές εκτιμήσεις. Επιπλέον, η διακύμανση του δείκτη διάθλασης του μέσου ξενιστή παράγει 2 τάξεις μεγέθους υψηλότερη ευαισθησία σε σύγκριση με τον δείκτη διάθλασης νανοράβδου ή υπερστρώματοςαλλαγές. Σε ορισμένες διαμορφώσεις, και οι δύο λειτουργίες TE και TM του μετατροπέα μεταϋλικού έχουν συγκρίσιμες ευαισθησίες που ανοίγουν ευκαιρίες για πολυπλεξία πόλωσης σε πειράματα ανίχνευσης. Η αξία της προαναφερθείσας δομής είναι κατά μία τάξη μεγέθους υψηλότερη από τον πολαρίτη του επιφανειακού πλασμονίου και τους εντοπισμένους αισθητήρες πλασμονίου επιφανείας, καθιστώντας την ιδανική για ευαίσθητες εφαρμογές όπως χημειο- και βιοαισθητήρες και μη γραμμικές φωτονικές συσκευές. Το τρίτο μέρος ερευνά τις λεπτές μεμβράνες ρουθενικού στροντίου ως νέο υλικό για πλασμονικές εφαρμογές σχεδόν IR. Αποδεικνύεται ότι η πλασμονική τους συμπεριφορά μπορεί να βελτιστοποιηθεί από τις συνθήκες εναπόθεσής τους που οδηγούν σε μια επιλεκτική και ρυθμίσιμη συχνότητα πλάσματος σε εύρος 324 - 392 nm και μήκος κύματος σχεδόν μηδενικό έψιλον σε εύρος 1,11 - 1,47 μm. Οι εφαρμογές αυτών των μεμβρανών κυμαίνονται από νανοδομές που παράγουν θερμότητα στο φασματικό εύρος σχεδόν IR, έως ιδανικούς απορροφητές με βάση μεταϋλικά και εξαρτήματα σχεδόν μηδενικά έψιλον, όπου απαιτείται η αλληλεπίδραση μεταξύ πραγματικών και φανταστικών τμημάτων της διαπερατότητας σε μια δεδομένη φασματική περιοχή για τη βελτιστοποίηση του φάσματος εκτέλεση.
Toward paratuberculosis control in animals: current updates and future perspectives
Authors: El-Sayed AA , Kamel M , Zschoeck M
Published: January 2024

Paratuberculosis is a chronic non-curable disease, that affects domesticated and wild ruminants, pets and even humans. This disease causes significant economic losses worldwide. Many countries have implemented control programs to eradicate the disease. Such programs face great challenges due to the nature of the pathogen itself, the immune response, the method of pathogen shedding in susceptible animals, and the absence of accurate diagnostic tools, efficient vaccines, and curative medication. However, some control programs succeeded in eradicating the disease, others were less effective and achieved less success. The present review discusses the elements required in disease control protocols and highlights the importance of disease elimination. These control strategies include optimum application of management measures and proper use of combined diagnostic techniques to accurately identify MAP infected animals with high sensitivity and specificity. Nanotechnology has shown promising results in the diagnosis and control of paratuberculosis. All available vaccines do not completely protect the population, but they actually reduce the clinical signs, pathogen shedding and provoke cellular and humoral immune responses. Although the test and slaughter policy of paratuberculosis is considered an effective way for its control, several obstacles hinder its application.
Comparison of some biological activities of propolis and bee bread samples obtained from Apis mellifera Anatoliaca and its Muğla and Efe ecotypes
Authors: Kabakci D
Published: January 2024

Honey and other bee products have been extensively researched in recent years due to the demand for natural products with nutritional and therapeutic qualities, as they contain high levels of biologically active compounds and valuable nutrients. In this study, antioxidant, anti-inflammatory and antimicrobial activities of bee bread and propolis samples formed after colony development by bees of different races and ecotypes accepted to core colonies in the same location were evaluated. Total phenolic, flavonoid and antioxidant content values were the the highest in propolis samples, especially in propolis from Apis mellifera anatoliaca. Values of this type gave the most effective results in almost all of the other tests performed, such as DPPH free radical scavenging, lipid peroxidation inhibition, anti-inflammatory and antimicrobial activity. In addition, the amount of phenolics detected in the phenolic component analysis of this species is higher. It was surprising that propolis samples obtained from Efe and Muğla ecotypes showed higher values, respectively, in the test for chelating activity with Fe. The fact that the values calculated for the bee breads were lower in all cases compared to the propolis samples, the highest values were calculated for the bee bread harvested from the efe ecotype, in contrast to the propolis ecotypes. None of the tested bee breads showed antimicrobial activity on selected pathogenic bacteria. Thus, with this study, it was evaluated how the differences arising from both race and ecotype and the type of bee product reflected on biological activities.
Effects of whey-enriched drinking water on fattening merino lamb growth, hemogram, inflammation, oxidant and antioxidant parameters
Authors: Danyer E , Bilal T , Altiner A , Eseceli H
Published: January 2024

This study aimed to evaluate the oxidative stress and inflammation status of ad libitum whey consumption as drinking water on fatting Merino lambs (n=24). Lambs were randomly divided into two groups and received ad libitum freshwater or whey enriched water and had clover as roughage and lamb grower feed as concentrate daily. Blood samples were collected before the trial (T1), on the 15th (T2) and 30th (T3) days and analyses were conducted on hemogram, serum antioxidant enzymes (Superoxide dismutase, SOD; Glutathione peroxidase, GSH-Px) inflammation response (C-Reactive Protein, CRP), complement activation, and chemokine marker (complement component 4, C4), lymphocyte activation factor (Interleukin 1 beta, IL-1 β), systemic inflammation cytokine (Tumor necrosis factor-alpha, TNF-α), lipid peroxidation marker (Malondialdehyde, MDA). The rate of hematocrit was found to be higher in the experimental group in T3 (35.55 ± 10.54) compared to the control group (44.50 ± 2.58). The platelet amounts were found to be higher in the whey group in T2 and T3 compared to the control group (p<0.05). In conclusion, with the use of whey protein-enriched drinking water, no significant change was observed in the amounts of TNF-α, SOD, MDA, IL-1β, C4, CRP under these study conditions.
Effect of GnRH and hCG Treatment Following a Short-Term Estrus Synchronization Protocol on Ovulation and the Fertility in Merino Ewes, During the Breeding Season
Authors: Dogan I , Toker MB , Aktar A , Yilmaz MM
Published: January 2024

This study aimed to compare the effect of hCG or GnRH administered 36 h following a short-term estrus synchronization treatment on the ovulation time and pregnancy rates of Merino ewes during the breeding season. The estrus cycles of ewes were synchronized with an intravaginal sponge containing 60 mg of medroxyprogesterone acetate for 6 days, and an injection of 400 IU of eCG and 125 µg of d-cloprostenol 24 h before sponge removal. Thirty-six h after the sponge removal, ewes were injected intramuscularly either 1 ml of physiological saline solution (control-group; n=14), 100 IU of hCG (hCG-group; n=14) or 0.004 mg of buserelin acetate (GnRH-group; n=14). The estrus behavior was observed using teaser rams and the ovulation time was monitored using transrectal ultrasonography twice daily for 96 h after the sponge removal. Ewes in estrus were allowed a single mating using fertile rams. Estrus response was higher (P<0.05) in the control group (92.86%) than in the GnRH group (50.00%). The interval from sponge removal to ovulation and from hCG to ovulation were shorter in the control group than in the hCG group (70.55, 80.83 h; 34.55, 44.83 h, respectively, P<0.05). In conclusion, administration of hCG or GnRH at 36 h following a short-term estrus synchronization protocol did not affect estrus behaviors, ovarian findings and pregnancy rates in ewes during the breeding season.
Investigation of Boron Addition to Dried Alfalfa In Vitro Ruminal Profile and Potential for Reducing Enteric Methane Emission
Authors: Durna Aydin Ö , Yildiz G , Toygar U
Published: January 2024

The aim of our study is to investigate the effects of increasing doses of boron on methane gas production amounts, short chain fatty acids level, protozoa number and organic matter digestibility in vitro with HFT (Hohenheim Futterwert Test) technique. In vitro incubation was performed in the Hohenheim Gas test method at 39°C for 24 hours in the study. Dried alfalfa was used as substrate for fermentation. Increasing doses of boron were used on fresh rumen fluid, buffer solution and dried alfalfa. In the study, 54 syringes were used for a total of 6 groups, including 1 control and 5 trial ( B1: 25 ppm boric acid, B2: 50 ppm boric acid, B3: 100 ppm boric acid, B4: 200 ppm boric acid, B4: 500 ppm boric acid). The measurement of methane gas at 2, 4, 6, 8, 12 and 24th hours of boric acid addition at increasing doses was found to be significant the difference between the groups at each hour under in vitro rumen conditions. When we look at the effect of the dose; Increasing doses appear to reduce methane production for each measured hour. The difference between the measured hours (except the 24th hour) of each group was not significant. However, the difference between the groups was found to be significant in the methane measurement made only for the 24th hour. At the 24th hour of fermentation under in vitro rumen condition, acetic acid and total short chain fatty acid values were linearly and cubically affected. With increasing doses of boron, propionic acid, isobutyric acid, butyric acid and valeric acid values were linearly affected The total number of protozoa was not affected by the addition of increasing doses of boron at the 24th hour of fermentation under in vitro rumen conditions. Consequently, the addition of boric acid at increasing doses in in vitro rumen conditions decreased methane production and positively affected the amount of some short-chain fatty acids, organic matter digestibility and total short chain fatty acids. In the light of these findings, it was emphasized that boron has the potential to reduce methane emissions from ruminant animals, considering the greenhouse gas effect.
Caecal dilatation and dislocation in 20 dairy cows. A retrospective study.
Authors: Proios I , Hoedemaker M , Kiossis E
Published: January 2024

A total of 20 cows with caecal dilatation and dislocation were included in this retrospective study. The aim of the study was to describe the findings of the initial clinical examination, the haematological, biochemical and venous blood gas analysis as well as the therapeutic management and the surgical findings of these cases. A positive simultaneous percussion and auscultation in the right flank as well as rectal palpation of the distended caecum were the most common findings in 90% of the animals. Increased haematocrit, hyperlactateaemia and hyperglycaemia were the most often occurring laboratory findings. Conservative treatment using neostigmine s.c. (0.025mg/kg) was successful in three out of four cases. Surgical therapy including laparotomy in the right flank and typhlotomy was performed in 17 cases. Caecal dilatation (n=9), retroflexion (n=4) and torsion (n=4) were revealed intraoperatively. During surgery in three cows, the caecum had filled once again with fluid content and typhlotomyhad to be repeated. Typhlectomy was not necessary in any of these cows. A relaparotomy due to recurrence of the caecal disorder was not required in any of the cases during hospitalisation. The postsurgical treatment included antibiotics, neostigmine in all cows and fluid therapy in the majority of the animals. Laxative treatment using 250 g sodium sulphate twice daily per os was applied in 10 cases. All cows were discharged from the clinic and returned to the farm.
Investigation of the presence of equine herpesvirus-1 (EHV-1) in tissue samples of aborted foals by histopathological, immunohistochemical, and Real-Time PCR techniques
Authors: Deniz Sezgin , Gülçubuk Ahmet , Sönmez Kıvılcım , Altan Eda , Aytemiz Danyer Işıl , Gürel Aydın , Yılmaz Hüseyin
Published: January 2024

Equine herpesvirus-1 (EHV-1) is a cause of pneumonia, encephalitis, and abortion in horses. Abortions occur alive or dead in the last trimester of pregnancy. The aim of this study is to investigate the incidence of EHV-1 infections in the tissue samples of aborted stillborn and live-born foals and the foals which died soon after birth and compare and correlate the conventional histopathologic diagnosis with IHC and Real-Time PCR. For this purpose, tissue samples (lung, liver, spleen, kidney, placenta, and brain) of 38 foals from Istanbul, Kocaeli, Bursa, and Eskişehir provinces of Turkey between August 2009 and March 2011 were examined Real-Time PCR revealed 52.6 % positivity (20/38), whereas 39.4 % (15/38) positivity was achieved with IHC, which indicated a correlation between these two diagnostic methods. In histopathological evaluation, the inclusion body was found in at least one of the tissue sections belonging to the lung, spleen, and mostly liver of 20 foals (52.6%).  Tissue samples of the foals found to be positive by IHC and PCR revealed histopathologic findings compatible with the characteristics of the disease.
What are some clever ploys psychotherapists use to avoid knowing their own "foundational beliefs"?
Authors: R. Mahrer Alvin
Published: January 2024

ABSTRACT IS AVAILABLE IN THE PDF
Η επίδραση της σκηνής στην αναγνώριση αντικειμένων της: Πώς ερμηνεύεται αυτή;
Authors: Σουσαμίδου-Καραμπέρη Αικατερίνη , Ν. Λοΐζου Λοίζος
Published: January 2024

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Συστηματική και οικογενειακή θεραπεία: Κριτική ανασκόπηση των μετανεωτερικών εξελίξεων
Authors: Ανδρουτσοπούλου Αθηνά
Published: January 2024

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Μία κριτική ματιά στην ενσυναίσθηση
Authors: Μαλικιώση - Λοΐζου Μαρία
Published: January 2024

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Η ατελής αρχιτεκτονική της ανθρώπινης οντογένεσης: Επιλογές, βελτιστοποίηση και αντιστάθμιση ως θεμέλια της αναπτυξιακής θεωρίας
Authors: B. Baltes Paul
Published: January 2024

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Γέφυρες προσέγγισης ανάμεσα στην ψυχολογία και τη φαρμακολογία
Authors: Παναγής Γεώργιος
Published: January 2024

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Το προφίλ μαθητών και μαθητριών με βάση υγιεινές και ανθυγιεινές συμπεριφορές: Σχέσεις με τον αθλητισμό
Authors: Θεοδωράκης Γιάννης , Παπαϊωάννου Αθανάσιος
Published: January 2024

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Η επίδραση της ηθικοποίησης στη μειονοτική επιρροή: Παράγοντες αντίστασης ή διευκόλυνσης
Authors: Τσιάμης Γεώργιος
Published: January 2024

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Πρόληψη του καπνίσματος στο χώρο του σχολείου: Παρατηρήσεις από την εφαρμογή ενός πιλοτικού προγράμματος
Authors: Κουμή Ιωάννα , Τσιάντης Ιωάννης
Published: January 2024

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Προκαταρκτική μελέτη των ψυχομετρικών χαρακτηριστικών της Κλίμακας Ακαδημαϊκών Κινήτρων
Authors: Τσορμπατζούδης Χαράλαμπος , Μπαρκούκης Βασίλειος , Γρούϊος Γεώργιος
Published: January 2024

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Η Σχολική Ψυχολογία στην Ελλάδα: Διαπιστώσεις και προοπτικές
Authors: Παρασκευόπουλος Ιωάννης
Published: January 2024

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Μία κοινωνιοψυχολογική προσέγγιση του τρόπου πρόσληψης των ελληνικών κοινωνικών κατηγοριών
Authors: Μαντόγλου Άννα
Published: January 2024

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The IV European Congress of Psychology: Ένας απολογισμός
Authors: Γεώργας Δημήτρης , Μπεζεβέγκης Ηλίας , Χαντζή Αλεξάνδρα , Βελλή Θεώνη , Καΐλα Μαρία , Δημητρίου Ανδρέας
Published: January 2024

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Creative thinking: A cognitive process in counseling
Authors: Malikiosi-Loizos Maria
Published: January 2024

ABSTRACT IS AVAILABLE IN THE PDF
Young children's understanding of other people's inferences
Authors: Varouxaki Angela , H. Freeman Norman
Published: January 2024

ABSTRACT IS AVAILABLE IN THE PDF
Frame-of-Reference Effects in Psychophysics: New Experimental Findings with Baby Chicks
Authors: Sarris Victor
Published: January 2024

ABSTRACT IS AVAILABLE IN THE PDF
The integration of cognitive, metacognitive and affetive factors in self-regulated learning: The effect of task difficulty
Authors: Georgiadis Lillian , Efklides Anastasia
Published: January 2024

ABSTRACT IS AVAILABLE IN THE PDF
Γλωσσάρι
Authors: Ευκλείδη Αναστασία , Κάντας Αριστοτέλης
Published: January 2024

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Relations between self-esteem, perceived control, possible selves and academic achievement in adolescents
Authors: Leontari Angeliki , Gialamas Vasilios
Published: January 2024

ABSTRACT IS AVAILABLE IN THE PDF
Drug effectiveness for COVID-19 inpatients inferred from Japanese medical claim data using propensity score matching
Authors: Mitsushima Shingo , Horiguchi Hiromasa , Taniguchi Kiyosu
Published: January 2024

Background Earlier studies and clinical trials of Coronavirus 2019 (COVID-19) showed that drugs such as antiviral drugs, antibody cocktails, and steroids and anti-inflammatory drugs can prevent severe outcomes and death. Methods Observational data in Japan assess drug effectiveness against COVID-19. We applied the average treatment effect model, particularly propensity scoring, which can treat the choice of administered drug as if administration were randomly assigned to inpatients. Data of the Medical Information Analysis Databank, operated by National Hospital Organization in Japan, were used. The outcome was defined as mortality. Subjects were all inpatients, inpatients with oxygen administration, and inpatients using respiratory ventilation, classified by three age classes: all ages, 65 years old or older, and younger than 65 years old. Information about demographic characteristics, underlying disease, administered drug, the proportions of Alpha, Beta and Omicron variant strains, and vaccine coverage were used as explanatory variables for logistic regression. Results Estimated results indicated that only one antibody cocktail (sotrovimab, casirivimab and imdevimab) was associated with raising the probability of survival consistently and significantly. By contrast, other drugs, an antiviral drug (remdesivir), a steroid (dexamethasone), and an anti-inflammatory drug (baricitinib and tocilizumab) were related to reduce the probability of survival. However, propensity score matching method might engender biased results because of a lack of data such as detailed information related to intervention and potential confounders. Therefore, the effectiveness of some drugs might not be evaluated properly in this study. Conclusions Results indicate high likelihood that antibody cocktails were consistently associated with high probability of survival, although low likelihood was found for other drugs for older patients with mild to severe severity and all age patients with moderate severity. Further study is necessary in light of the lack of available data.
Interspecific competition affects spore germination and gametophore development of mosses
Authors: Cheng Jingmin , Lončarević Isidora , Cronberg Nils
Published: January 2024

Background Interactions between moss species in their earliest growth stages have received little attention. To what extent interspecific competition or priority effects influence spore germination, protonemal development and gametophore emergence is unknown. We evaluated such effects in pairwise interaction between six common bryophyte species: Atrichum undulatum, Bryum argenteum, Ceratodon purpureus, Funaria hygrometrica, Hypnum cupressiforme, Leptobryum pyriforme Methods Interspecific interactions were assessed in vitro. Spores were sterilized and sown on agar plates in three treatments: 1) as single species cultures (controls), 2) as pairwise species cultures inoculated simultaneously, and 3) with a time lag of 20 days between species. Data on time needed for spore germination, germination rate, the time needed for gametophore differentiation, number of gametophores per germinated spore and average diameter of colonies were collected. We also performed spore germination tests in single-species cultures at the start and end of the study, as well as tests for density-dependency at spore germination and gametophore formation. Results We observed strong pairwise interactive effects when sowing spores of different species simultaneously or with a delay of 20 days. The results indicate that spore germination is often inhibited by interspecific competition. The first species has an advantage as compared to the later colonizing species, i.e., an apparent priority effect. Interspecific interactions were also evident during gametophore development and included both inhibition and facilitation. Conclusion We found pronounced differences in the relative performance of species in interaction with other species during spore germination and gametophore formation. Allelopathic effects are the most probable explanation for these observations. Our results under sterile lab conditions are likely to reflect processes that occur in the wild, governing biotic filtering and bryophyte community assembly during primary and secondary colonization.
Marginal fit of three different nanocomposite inlays fabricated with computer-aided design/computer-aided manufacturing (CAD/CAM) technology: a comparative study
Authors: Choi Hyunsuk , Jo Jae-Young , Hong Min-Ho
Published: January 2024

Background: This study aimed to compare and evaluate the marginal fit of nanocomposite computer-aided design/computer-aided manufacturing (CAD/CAM) inlays. Three types of nanocomposite CAD/CAM blocks (HASEM, VITA Enamic, and Lava Ultimate) were used as materials.Methods: Class II disto-occlusal inlay restorations were prepared on a typodont mandibular right first molar using diamond rotary instruments. The inlays were fabricated using CAD/CAM technology and evaluated using the silicone replica technique to measure marginal gaps at five locations on each inlay. The data were analyzed by two-way analysis of variance and Tukey post hoc tests ( α=0.05).Results: There were no significant differences in the marginal gaps based on the type of nanocomposite CAD/CAM inlay used (p=0.209). However, there was a significant difference in the marginal gaps between the measurement regions. The gingival region consistently exhibited a larger marginal gap than the axial and occlusal regions (p<0.001).Conclusion: Within the limitations of this in vitro study, the measurement location significantly influenced the marginal fit of class II disto-occlusal inlay restorations. However, there were no significant differences in the marginal gaps among the different types of CAD/CAM blocks. Furthermore, the overall mean marginal fits of the class II disto-occlusal inlay restorations made with the three types of nanocomposite CAD/CAM blocks were within the clinically acceptable range.
Digital Workshop: Text and table processors
Authors: Apatova Natal'ya , Bakumenko Mariya
Published: January 2024

The tutorial outlines the principles and methods of working in the text and tabular processors of the Microsoft Office and LibreOffice office packages used to solve professional tasks. The theoretical information is illustrated by examples. It contains theoretical material, practical tasks, control questions and tasks for
individual work.
For undergraduate students studying in all fields of study, as well as anyone who wants to master the functionality of text and table processors for use in professional activities.
Model for Assessing the Development of the Oil and Gas Industry with ESG Included
Authors: Lezhanin A.
Published: January 2024

This paper presents a model for assessing the development of the oil and gas industry, taking into account ESG factors such as the environment, social aspects and management activities. The model allows for a statistical analysis of each ESG factor and to determine its impact on the capitalization of oil and gas companies. The results of the analysis will help to assess the significance of each factor and understand how strongly and in what direction they affect the financial performance of companies. Such a model can be a useful tool for decision-making in the field of investment and risk management in the oil and gas industry, taking into account sustainable development. The work highlights the importance of taking ESG factors into account when evaluating and making decisions in the oil and gas industry in order to achieve sustainable and responsible development.