bluuebunny/crossref_metadata_2025 huggingface dataset:
Heart rhythm complexity impairment in end stage renal disease patients receiving haemodialysis
Authors: Sun Weiwei , Xiong Hui , Peng Chung-Kang , Ahn Andrew C. , Liu Qingqing , Yan Runze , Wu Qiaoru , Wei Shuwu , Yuan Kai , Zhou Jingwei
Published: June 2022

Cardiovascular disease (CVD) is one of the most common complications of end stage renal disease (ESRD) patients receiving haemodialysis (HD). A better understanding of the relationship between CVD and HD is important to improve life expectancy and reduce the mortality risk of ESRD patients receiving HD. Heart rate variability (HRV), also known as variations in heart rate, is a useful method to measure the autonomic nervous system dys-regulation with 24-h electrocardiogram (ECG). The variables of heart rhythm complexity could be acquired with multi-scale entropy analysis (MSE). We enrolled 31 ESRD patients receiving HD in this study. MSE was used as non-linear heart rate variability (HRV) in our study. MSE area was negative correlated with age. MSE area 10-20 was positive correlated with Kt/V, albumin (ALB) and hemoglobin (Hb). Furthermore, we found that the MSE area before HD was higher than the MSE area after HD. We also found that increased age was a deleterious factor of HRV in ESRD patients receiving HD. Kt/V, ALB, and Hb were beneficial factors of HRV in ESRD patients receiving HD. HD seemed to be a harmful factor of HRV in ESRD patients.
Status, threats, and overlap of globally important pangolins and threatened small carnivores in a disturbed wetland mosaic of southern Vietnam
Authors: Gray Russell , Nguyen Tan , Cao Long Nhat , Trinh Mai Thi , Pham Thong , Nguyen Huyen Thi Thanh , Willcox Daniel , Le Dzung , Nguyen Thai Van
Published: June 2022

The U Minh wetlands of southern Vietnam in Ca Mau and Kieng Giang provinces are a degraded, peat-swamp wetland mosaic known to retain several globally threatened species. We deployed intensive, targeted camera-traps across U Minh Thuong National Park and U Minh Ha National Park from December 2019 to May 2020, and from November 2020 to June 2021, respectively. Our aim was to detect threatened otters, wild cats, and pangolins in each protected area, to identify what potential threats they may face, and to inform conservation priorities for park managers. Our results showed that both protected areas harbour significant regionally important populations of globally threatened Sunda pangolins (Manis javanica), and Hairy-nosed otters (Lutra sumatrana). However, Fishing cats (Prionailurus viverrinus) and Large-spotted civet (Viverra megaspila) previously recorded from U Minh Thuong National Park, were not observed. Other than wide-ranging species insensitive to human disturbance (i.e., Common palm civets and Leopard cats), all small carnivores were most active in Melaleuca and swamp/Melaleuca habitats in U Minh Thuong, and both the wetland plantations and disturbed forests of U Minh Ha according to their photographic rates. Human and domestic dogs’ activity periods in both protected areas overlapped strongly with Hairy-nosed otters, which could influence their dispersal abilities and access to resources. Furthermore, dogs in this part of southern Vietnam are often used for hunting, so there is a strong possibility the overlap could lead to deadly interactions as well. Long-term and short-term threats are discussed with relevance to U Minh ecosystem health and future recommendations.
Single port thoracoscopic pulmonary metastasectomy can improve survival in esophageal cancer patients with pulmonary metastasis
Authors: Lo Chien-Ming , Chuang Kai-Hao , Lai Hsing-Hua , Chen Yu , Chen Li-Chun , Lu Hung-I , Chen Yen-Hao , Li Shau-Hsuan
Published: June 2022

Objectives:Esophageal cancer with pulmonary metastasis has a poor prognosis. Pulmonary metastasectomy provides benefits in selected patients; however, currently, there is no literature regarding single port surgery for these patients. We reviewed our institution’s data and analyzed patient outcomes after single port pulmonary metastasectomy.Methods:We retrospectively reviewed our patients with esophageal cancer and pulmonary metastasis. We categorized them into two groups - the pulmonary resection group and the systemic treatment group. We compared the overall survival and progression-free survival between groups and also analyzed the surgical modality, which includes single or multiple port surgery.Results:The analysis included 44 patients, 14 of whom received pulmonary metastasectomy. Ten patients underwent single port surgery. Single port pulmonary metastasectomy showed significant benefits on overall survival (p=0.0009), while all pulmonary resection demonstrated benefits on overall survival (p<0.0001) and progression-free survival (p=0.038).Conclusions:Single port pulmonary metastasectomy in patients with esophageal cancer demonstrated survival benefits even when this procedure was performed for tissue diagnosis.
Nonintrusive Measurement on Temporal and Spatial Features of Microservice Inferences
Authors: Li Xiaoyong , Yao Ruobing , Liu Biyong , Hu Haichuan , Xu Zichen , Tan Shuang , Tan Yusong , Xu Chenren
Published: June 2022

The high flexibility of microservice architecture provides notable divergence among the internal software stack within the same application. Microservice-based application are commonly deployed in data center from users yet they have no cue where or what existly are provided from the service provider. In this case, there could exist those providers could be able to replace the internal software without noticing, making a contract level fault and offloading risks to users. To better profile the microservice, we propose a framework that provides non-intrusive measurements on microservice inference, or MEME, to detect fraudulent behaviors of cloud service providers on microservice-based applications. We design MEME using performance portrait and fast Fourier transform (FFT). We model the microservice-based application with a set of cohorts and use FFT to obtain the signal formed by the main frequency components of average response time. Our model represents the performance portrait of the microservice-based application. The performance portrait is similar to a fingerprint that Nonintrusive Measurement of Microservice Inferences carries internal software information. In our experiments, we take a two-tier microservice-based application containing databases as an example. Empirical results show that MEME can provide a distinguishable profile of the performance portrait of data services in a temporal and spatial manner, which allows us to identify the software type.
Digital Health Technologies During COVID-19: A New Normal in Primary Health Care Delivery
Authors: Ndayishimiye Costase , Lopes Henrique , Middleton John
Published: June 2022

The primary health care (PHC) in the Alma-Ata Declaration of 1978, revisited in the Astana Declaration of 2018, underpins the fundamental goal of achieving universal healthcare coverage. The 2019 coronavirus pandemic (COVID-19) shows that rapidly spreading outbreaks can significantly hamper the provision of PHC. This study investigates how digital health technologies (DHTs) evolved to support the PHC sector during COVID-19 and lessons for the future improvement of PHC. A systematic review was conducted through database searches (PubMed, Scopus, and Google Scholar) and hand-searching of grey documents published in English between December 2019 and December 2021. The study employed thematic content analysis and synthesis. The final synthesis included 46 documents: 40 articles; one book; two book chapters; one working paper; and two technical reports. Around 19 major theme categories were found, with the top three being the eHealth category, comprising themes like telemedicine, e-prescription, telepsychiatry, and telehealth visits; the mHealth category, such as App-based telemedicine and mobile electronic patient records connecting patients, physicians, and health systems; and the device category, such as wearable technologies, telemedical stethoscopes, telemedical ECGs, and remote monitoring devices. Finally, 20 areas of use of DHTs were identified and then grouped into five main areas: 1st) provision of health services, such as general care (teleconsultations, diagnosis, testing, etc.) and managing chronic conditions; 2nd) communicating, informing, and educating roles (e.g., preventing vaccine hesitancy) and digital health literacy; 3rd) monitoring and surveillance roles (e.g., symptoms’ monitoring); 4th) vaccination and drug purposes (e.g. e-prescription, adverse-drug-reaction monitoring, etc.); and 5th) enhancing system decision-making. DHTs have the potential to solve some of the challenges that have plagued us even before COVID-19. Therefore, this study puts forward recommendations to further stimulate the use of evidence based DHT, making it more inclusive, educative, and satisfying to people's needs, both under normal conditions and during outbreaks. More research is required, with a focus on quality assurance in the use of digital health; technical aspects (standards for digital health tools, infrastructure, and platforms); and financial perspectives (payment for digital health services and adoption incentives).
Causes and treatment strategies of unilateral leaflet shedding of bileaflet mechanical prosthetic heart valves after surgery
Authors: Wang Xianzhi , QIU Jiawei , MU Cunfu , ZHANG Wenlin , XUE Chunzhu , HE Yang , MU Qinglin , FU Chunyang , LI Dianyuan
Published: June 2022

Objective: Unilateral leaflet shedding is a rare complication. This paper discusses the causes and treatment strategies of unilateral leaflet shedding of bileaflet mechanical prosthetic heart valves after surgery. Methods: This study was a retrospective study that included 1 case of unilateral leaflet shedding after mechanical valve replacement of the aortic valve in Fuwai Hospital in 2010 and 1 case of unilateral leaflet shedding after mechanical valve replacement of the mitral valve in the First People’s Hospital of Guangyuan in 2021. The new mechanical valves were replaced during subsequent surgeries. data were collected, and the patients were followed up for 10 years and 3 months after the operations, respectively. Results: The patient with an aortic valve replacement was a male; the patient with a mitral valve replacement was a female; and they had an average STS risk score of 3.9%. Both patients had severe regurgitation, and the results of the reoperations were satisfactory. After the operations, the echocardiograms showed that there was no regurgitation in either of the valve replacements. There were no changes in the ankle-brachial index (ABI) before and after the operation in either of the two patients, and no complications or deaths occurred during follow-up. Conclusion: The reason for the leaflet sheddings may be related to the valve design and the leaflet materia. If the detached leaflets are damaged and if the distal blood vessels are affected, simultaneous surgical treatment is required. Those patients whose vessels were not damaged by the valve lobe should be carefully monitored.
A study to assess the decision making power regarding postnatal diet, exclusive breast-feeding and family planning methods among postnatal women in selected rural communities of West Bengal
Authors: Maji Riku
Published: June 2022

A descriptive study was conducted to assess the decision making power regarding postnatal diet, exclusive breast feeding and family planning methods among postnatal women in selected communities of West Bengal. The conceptual framework was based on women autonomy which is adopted from the study “Women’s’ autonomy and reproductive healthcare-seeking behaviour” conducted in Ethiopia by Yohannes Dibaba Wado. Population was postnatal women who had children of six months of age group.. 180 samples were taken from the rural communities under Kelejora B.P.H.C. A validated and reliable structured interview schedule was used to assess the decision making power of postnatal women regarding postnatal diet, exclusive breast feeding and family planning methods. The findings of the study revealed that most of postnatal women ÷(97.8%) had strong decision making power in exclusive breast feeding whereas only 31.1% postnatal women had strong decision making power in family planning methods. Majority of (76.1%) postnatal women had strong decision making power regarding postnatal diet. Statistically significant association was observed between decision making power of postnatal women regarding postnatal diet and religion (÷2 = 12.0742, at df 4) at 0.05 level of significance. In the area of exclusive breast feeding there was significant association between decision making power regarding exclusive breast feeding and religion (÷2 = 23.28, at df 2) at 0.05 level of significance. There was statistical significant association between decision making power of postnatal women regarding family planning methods and age of women(÷2 = 17.7, at df 2) and parity of women (÷2 = 6.97, at df 2) at 0.05 level of significance. The study has a great implication in Nursing service, education, research and administration. Based on the findings the recommendation is made for a study to find out knowledge and practice regarding postnatal diet, exclusive breast feeding and family planning methods. It is concluded that the magnitude of women’s decision making power on postnatal diet and exclusive breast feeding is high in this study whereas the decision making power regarding family planning methods among postnatal women is very low.
Using Verbal Behavior Transfer Procedures to Increase Phonological Awareness
Authors: Reed Nathan , Kerr Madison
Published: June 2022

Verbal behavior is used when programming instruction for students with Autism to increase language repertoires and motivation to communicate. However, using verbal behavior to provide academic instruction is used less frequently. Reading is defined as the textual operant in Skinner’s 1957 analysis. The skills which lead to textual behavior such as phonological awareness have not received the attention that other non-verbal stimuli have received as an antecedent for evoking tacts. The current research uses ABAB design to determine the effectiveness of using verbal behavior transfer procedures to teach phonological awareness. · Echoic to Tact Transfer provides errorless phonological instruction.· Explicit 1:1 instruction with scheduled reinforcement was used.· Students possessed both an echoic and tact repertoire.· Sessions included target stimuli and previously mastered stimuli for instruction.
Relativistic effect inside matter. Obtaining a new dispersion formula.
Authors: Chernov Andrey
Published: June 2022

The main prerequisite for this study was the external similarity of such physical processes as the refraction of light in a transparent substance and the deflection of light by the gravitational field of massive cosmic bodies. Based on the external similarity, the author put forward a hypothesis about the internal similarity of these two physical processes. This made it possible to integrate Einstein's well-known relativistic formula into the process of light propagation in electron clouds (fields) of a transparent substance. As a result of the transformations carried out, a new physical dispersion formula with a wide spectrum of action was obtained from the Einstein formula. According to the new dispersion formula, 26 refractive indices of light were calculated in 5 transparent substances in 3 states of aggregation. Comparison of the obtained indicators with laboratory indicators showed the high accuracy of the new physical formula, which amounted to ±10 -7−10 -5 in the calculated sections of the wave ranges over 100 nm. The successful application of the relativistic formula to the process of light refraction in transparent substances indicates that relativistic effects are present at the atomic-molecular level.
Phytohormones Regulate the Non-redundant Response of ω-3 Fatty Acid Desaturases to Low Temperatures in Chorispora bungeana
Authors: Shi Yulan , Yang Sizhong , Yue Xiule , Zhao Zhixing , An Lizhe
Published: June 2022

Key message The cold-induced expression of ω-3 CbFAD genes were mainly regulated by jasmonie acid and brassinosteroid, and the accumulation of TAs below 0 ℃ was due to the contribution of CbFAD8 To explore the contributions of ω-3 fatty acid desaturases (FADs) to cold stress response in a special cryophyte, Chorispora bungeana (C. bungeana), two plastidial ω-3 FAD genes (CbFAD7 and CbFAD8) were cloned and verified in an Arabidopsis fad7fad8 mutant, before being compared with the microsomal ω-3 FAD gene (CbFAD3) on expression profile. Though these genes were expressed in all tested tissues of C. bungeana, CbFAD7 and CbFAD8 have the highest expression in leaves, while CbFAD3 was mostly expressed in suspension-cultured cells. Low temperatures (4, 0 and -4 ℃) resulted in significant increases in trienoic fatty acids (TAs, mainly C18:3), which were consisted with the cooperation of CbFAD3 and CbFAD8 in cultured cells, and the coordination of CbFAD7 and CbFAD8 in leaves. Furthermore, the cold induction of CbFAD8 in the two tissues were increased with decreasing temperature and independently contributed to TAs accumulation at -4 ℃. A series of experiments revealed that jasmonie acid and brassinosteroids participated in the cold-responsive expression of ω-3 CbFAD genes in both C. bungeana cells and leaves, while the phytohormone regulation in leaves was more complicated with the participation of abscisic acid and gibberellin. These results point to the hormone-regulated non-redundant contributions of ω-3 CbFADs to maintain appropriate level of TAs under low temperatures, which helps C. bungeana survive in cold environments.
PHYSICAL THERAPY IN DIABETIC PATIENTS INFECTED WITH COVID-19 ACUTE AND POST-ACUTE RECOVERY
Authors:   Sutter Health California, Midwestern State University Texas., Bhanushali P.T Pranav
Published: June 2022

Diabetes is the second highly prevalent disease among chronic diseases in patients with COVID-19 and is responsible for high morbidity and mortality in COVID-19 patients. Diabetic patients with uncontrolled glycemic levels have a worse prognosis than patients who have strict glycemic controls. During the COVID-19 pandemic, the importance of social distancing measures has reduced physical activity in people due to home quarantine and lockdowns. COVID-19 disease can affect the functional capacity and occupational health of diabetic patients. This fact urges the need for physical therapy during the active and recovery phase of COVID-19 disease. This review study has analyzed the effects of physical therapy in COVID-19 patients previously suffering from diabetes during the active and recovery phases. Different articles were retrieved from PubMed and a literature review was conducted. A complete evaluation of different studies revealed four topics that correspond to the results of this study. 1) Physical therapy in non-hospitalized diabetic patients suffering from COVID-19 disease 2) Physical therapy in hospitalized and ICU diabetic patients suffering from COVID-19 disease 3) Physical therapy in diabetic patients recovering from COVID-19 disease 4) Role of physical therapists in the battle against COVID-19. The findings of the previous studies showed that COVID-19 has significant effects on the physical capacity of sufferers especially those with a chronic disease like diabetes. This fact implies that physical therapists should also be involved in the battle against COVID-19 diseases for improving the functional capacity during both the active and recovery phase of the illness.
Molecular identification and phylogenetic analysis of free-living amoeba in the water resources of Arak, Iran
Authors: Fani Malihe , Fuerst Paul A. , Mosayebi Mahdi , Javadi Amir , Harandi Majid Fasihi , Saraei Mehrzad , Badri Milad , Hajialilo Elham
Published: June 2022

The aim of the present study was to detect free-living amoeba (FLA) in the water resources of Arak, Iran using molecular tools. A total of 154 samples were collected from different water supplies. Molecular analyses, sequencing, and phylogenetic study were conducted to confirm the species and genotypes of FLA. Fisher exact test was used to determine the significance. Of 154 water samples, 19 (12.3%) samples were tested positive for FLA. Three genotypes of Acanthamoeba including T4, subtype D, and T5 were identified among the isolates. The pathogenicity assay showed that the isolate of Acanthamoeba in drinking water was highly pathogenic. Three species of Naegleria, including N. australiensis, N. pagei, and N. gruberi were found among the samples. Six isolates of Vermamoeba were identified as V. vermiformis. Meanwhile, three other species including Vannella sp., Vahlkampfia avara, and Stenamoeba polymorpha were also recovered from the water samples. Statistical analysis showed a significant difference between the various water resources contaminated with FLA. This is the first study to reveal the presence of S. polymorpha in water sources in Iran. According to the findings of the present study, health officials should be beware of potential public health impacts of FLA in water resources.
Identification of the water source and groundwater recharge in a paddy field using stable hydrogen and oxygen isotopes
Authors: Chou Mon-Lin , Tseng Hong-Yang , Wang Chung-Ho , Hseu Zeng-Yei
Published: June 2022

The stable isotopes of oxygen-18 and deuterium were utilized to identify different water sources mixing in the soil layer that recharged to groundwater of a paddy field during the growth season in 2014. Based on the measurements of deuterium and oxygen-18 in soil water, rainwater and groundwater in the paddy field of Chianan Plain in Southwest Taiwan in the wet season was collected, and the relationship between δD and δ18O in soil water and groundwater recharge was investigated in this study. The soil water in the paddy field of Chianan plain was collected with suction lysimeters for the identification of different sources of subsurface flow. The isotopic compositions of hydrogen and oxygen in different water bodies were used to evaluate the groundwater recharge sources in the paddy field. The intensity of rainfall and evaporation influenced the saturation conditions of pore water present in the soil layer. In general, transiently intense rainfall tended to be difficult in recharging groundwater. The results show the use of stable isotopes in water bodies can be used to monitor or identify the source/sink of soil layer and their respective contributions to groundwater recharge. In this research, the isotopic compositions of hydrogen and oxygen in the soil water at different depths before and after event water were identified. The top soil layer (<30 cm depth) in the presence of the isotope depleted soil water was probably subjected to evaporation. The soil water has more depleted isotope composition that was observed in shallow soil layers. More depleted fraction of isotopes in groundwater was similar to rainwater, which suggested that the groundwater was primarily from rainfall. In addition, the isotopic compositions of hydrogen and oxygen in groundwater slightly deviated from the local meteoric water line in southern Taiwan.
Avaliação da potência de aparelhos fotopolimerizadores em consultórios odontológicos variando a sua distância do radiômetro
Authors: Luis Eduardo Duarte Irala  , Filipe Reis Garcia  , Ricardo Prates Macedo  , Adair Luiz Stefanello Busato  , Cristiane Silva Silveira
Published: June 2022

A luz emitida para a cura das resinas deve ter um espectro de comprimento de onda próximo ao de absorção da canforoquinona, fotoiniciador mais frequentemente encontrado nas resinas compostas fotopolimerizáveis. As principais demonstrações clínicas de problemas causados por compósitos de resina fotopolimerizada estão ligadas à profundidade de cura limitada e à menor taxa de polimerização profunda dentro do compósito de resina. Objetivo: Avaliar potência de aparelhos fotopolimerizadores variando a distância da fonte de luz ao captador. Material e métodos: Usou-se um radiômetro (Woodpecker LM-1), testando-se 12 aparelhos fotopolimerizadores, em contato direto com o captador do aparelho, a 4 mm e 8,7 mm de distância. Os dados obtidos dos aparelhos de intensidade de luz foram catalogados e analisados de acordo com a intensidade luminosa em limites previamente determinados. Resultados: Nenhum aparelho fotopolimezador em contato direto com o radiômetro apresentou a potência indicada pelo fabricante. Todos os aparelhos testados perderam potência quando afastados 4 mm e 8,7 mm do radiômetro. Conclusão: A distância da ponta ativa do fotopolimerizador interferiu na intensidade de luz emitida proporcionalmente ao aumento da distância, reforçando os cuidados necessários durante a fotopolimerização.
Considerações sobre o planejamento multiprofissional entre dentista, fonoaudiólogo e psicólogo nas reabilitações com próteses bucomaxilofaciais: uma revisão sistematizada
Authors: Romero Gomes da Silva  , Sabrina Gomes Martins Soares  , Leiliane de Oliveira Costa  , Gustavo Leite Coelho Martins de Oliveira  , Viviane Feliciano Pereira  , Rafael de Oliveira Ambrósio  , Jean Soares Miranda  , Alexa Magalhães Dias
Published: June 2022

O percentual de indivíduos acometidos por lesões neoplásicas tem aumentado nos últimos anos. Assim, a procura por reabilitações com próteses bucomaxilofaciais é expressiva. Nesse processo, o cirurgião-dentista, em consonância com fonoaudiólogos e psicólogos, deve desenvolver um plano de tratamento coerente e funcional para a restauração aloplástica do defeito maxilofacial. Objetivo: Revisar os aspectos psicológicos e fonoaudiológicos envolvidos no processo reabilitador, com próteses bucomaxilofaciais, de pacientes submetidos a cirurgias de ressecção de tumores, ressaltando a importância da atuação multiprofissional durante o atendimento desses pacientes. Material e métodos: A revisão da literatura foi realizada por meio de pesquisas em quatro bases de dados: Embase, Scopus, PubMed e Google Scholar. Utilizaram-se os seguintes descritores: maxillofacial prosthesis, maxillofacial prosthodontics, maxillofacial prosthetics, facial prosthesis, psychology, speech therapy, speech-language-hearing e maxillary speech. Foram incluídos estudos que abordaram os aspectos psicológicos ou fonoaudiológicos relacionados à reabilitação com próteses bucomaxilofaciais em pacientes submetidos a cirurgia de resecção de tumor em região de cabeça e/ou pescoço. Resultados: A busca primária resultou em 1.702 artigos. No entanto apenas 37 trabalhos se enquadraram nos critérios de inclusão para leitura na íntegra e tratamento de resultados. Conclusão: O atendimento multiprofissional é de suma importância para a reabilitação aloplástica de pacientes com defeitos bucomaxilofaciais, pois favorece o restabelecimento de funções orais, tais como a mastigação, fala e deglutição. Além disso, o tratamento psicológico é essencial para a reinserção do paciente na sociedade, uma vez que proporciona melhoria da qualidade de vida, oferecendo ao indivíduo mecanismos para aceitação do tratamento e adequado enfrentamento da mutilação bucomaxilofacial.
Pulp neurovascular plexus response as a result of crown-root horizontal fracture and uncomplicated crown fracture in permanent dentition: a case report
Authors: Isabela Ribeiro Madalena  , Patrícia Valéria Manozzo Kunz  , Carolina Paes Torres  , Alexandra Mussolino Queiroz  , Erika Calvano Küchler  , Francisco Wanderley Garcia Paula-Silva
Published: June 2022

Dental trauma often have severe and complex injuries to the dentoalveolar system. Objective: To report the treatment of crown-root horizontal fracture and uncomplicated crown fracture in permanent dentition. Case report: Child patient attended the dental trauma service 30 days after the fall. On clinical and imaging examination, an uncomplicated crown fracture in the right central incisor and crown-root fracture in the left central incisor was possible to identify (tooth 11 and tooth 21 respectively). The conventional restorative treatment (tooth 11) and repositioning (tooth 21) were performed. The endodontic treatment was performed at 6 months of follow-up (tooth 11). At the new imaging exam, cement neoformation was evidenced between the fragments of the crow-root fracture (tooth 21). After 24 months of follow-up, there was a decrease in periapical lesion (tooth 11), and maintenance of pulp vitality (tooth 21). Conclusion: There is a possibility of maintaining pulp vitality in crown-root fractures and highlights the importance of follow-up in non-complicated fractures.
Anomalous Migration of Horse Erythrocyte Spectrin Dimers in Native Polyacrylamide Gels
Authors: Bobich Joseph A. , Walli Cleatus J.
Published: June 2022

A novel property of equine erythrocyte spectrin permits visualization of two forms of the dimer on natite
polyacrylamide gels. This is not due to membrane extraction temperature, protein phosphorylation state, Ca2+
binding, homodimer formation, or endogenous proteolysis. The less hydrophobic (dimer2) conformer is more
susceptible to cleavage by endogenous and exogenous protease, suggesting that dimerl and dimer2 represent closed and open conformers, respectively.
Application of Artificial Intelligence in Drug Discovery
Authors: Chopra Hitesh , Baig Atif A. , Gautam Rupesh K. , Kamal Mohammad A.
Published: June 2022

Due to the heap of data sets available for drug discovery, modern drug discovery has taken the shape of big data. Usage of Artificial intelligence (AI) can help to modify drug discovery based on big data to precised, knowledgeable data. The pharmaceutical companies have already geared their departments for this and started a race to search for new novel drugs. The AI helps to predict the molecular structure of the compound and its in-vivo vs. in-vitro characteristics without hampering life, thus saving time and economic loss. Clinical studies, electronic records, and images act as a helping hand for the development. The data mining and curation techniques help explore the data with a single click. AI in big data analysis has paved the red carpet for future rational drug development and optimization. This review's objective is to familiarise readers with various advances in the AI field concerning software, firms, and other tools working in easing out the labor of the drug discovery journey.
Gastroretentive Drug Delivery System in Cancer Chemotherapy
Authors: Rath Goutam , Anothra Pooja , Pradhan Deepak , Halder Jitu , Ghosh Goutam
Published: June 2022

Background:

Chemotherapy for stomach cancer often includes several side effects. The primary
reasons for the failure of such treatment approaches are low drug concentrations in target tissues
and a short stomach residence time.

Objective:

Gastroretentive controlled drug delivery systems improves the therapeutic performance of
chemotherapeutic drugs following oral administration because of the longer gastric retention time. The
goal of this study was to find suitable gastroretentive formulations that might be used for the localized
treatment of stomach cancer.

Method:

The purpose of this study is to summarize current advances in gastro-retentive drug administration
for oral chemotherapy, with a focus on floating, mucoadhesive, and swellable systems. This
article also discusses the potentials and limitations of existing gastroretentive drug delivery systems
used in cancer chemotherapy.

Result:

Due to increased stomach retention and modified drug release properties, gastroretentive controlled
drug delivery systems improve the therapeutic performance of anti-cancer drugs used to treat
stomach cancer.

Conclusion:

Gastroretentive drug delivery systems appear to be a promising carrier for localized chemotherapy
with smaller doses and better patient compliance. However, selection of drug candidates, drugfood
interactions and chemotherapy-induced gastric discomfort remain the key characteristics that must
be addressed to improve treatment outcomes.
The Potential Effect of Blueberry on Cognitive Health and Mood State
based on Human Intervention Studies: Systematic Review and Mini
Meta-Analysis
Authors: Soveid Neda , Barkhidarian Bahareh , Moradi Sajjad , Gholami Fatemeh , Rasaei Niloufar , Himmerich Hubertus , Mirzaei Khadijeh
Published: June 2022

Background:

Blueberries are known for their high content of several bioactive compounds,
specifically anthocyanin, which are the most beneficial of the flavonoid family in terms of neuroprotection.
Several human interventional studies have been conducted to assess the effects of blueberry
intake on cognitive performance; however, the results of clinical trials are inconclusive. Therefore, this
systematic review and meta-analysis evaluated the effect of blueberry supplementation on some aspects
of cognitive performance and mood parameters using data from clinical trials based on existing
evidence.

Methods:

Relevant studies, published in April 2021, were searched through PubMed/Medline, Scopus,
Embase, and Google Scholar. The random effect size was used to estimate the pooled effect size. Heterogeneity
between studies was evaluated by the Cochrane Q test and I-squared (I2). To detect the
potential source of heterogeneity, a subgroup analysis was conducted.

Results:

Fourteenrandomized trials were included in the quantitative analysis, and six were pooled
for statistical analysis. Blueberry intervention resulted in no significant change in mood state score
(WMD = 0.03; 95% CI:-0.80 to 0.87, P = 0.16). Moreover, no significant effect of blueberry intake
was shown in attention task reaction time (WMD = -1.50 ms; 95% CI:-24.75 to -21.75, P = 0.9), percentages
of attention task accuracy (WMD = 0.85; 95% CI:-2.57 to 0.86, P = 0.3), one-back test accuracy
(WMD = 0.03; 95% CI:-0.04 to 0.09, P = 0.4). Significant effect was indicated (WMD = 0.08;
95% CI: 0.02 to 0.13, P = 0.005) in two-back test accuracy.

Conclusion:

We found a significant effect of blueberry consumption on two-back test accuracy as a
cognitive outcome. More high-quality clinical trials according to the challenges mentioned seem to indicate
the use of blueberry as a supplement for cognitive and mood health efficiently.
Classification of Halophytes
Authors: Attia-Ismail Salah Abdelaty
Published: June 2022

Halophytes are a small group of higher plants. They represent about 1% of
the world’s flora. There is no unanimous consensus on a distinct definition of
halophytes. This is because of the taxonomic and ecological complexities of halophytes
as well as their heterogeneity. Some authors consider the salt content of the native
habitats to be the basis for the classification of halophytes. Others concentrated on the
response of plants to salinity. However, different basal halophyte classifications are
discussed in this chapter.
Minerals and Ash in Halophytes
Authors: Attia-Ismail Salah Abdelaty
Published: June 2022

Since the halophytes complete their life cycle in a salty environment, they,
consequently, have a high content of minerals in their components. The high content of
ash is a typical characteristic of halophytes. However, the ash content of halophytes
differs greatly according to several factors. This chapter discusses how halophytes vary
in ash and ion content, the effects of halophyte species on mineral compositions, and
geographic variations in the mineral contents of halophytes.
Brachioradial Pruritis Due to Cervical Spine Pathology (Preprint)
Authors: grabnar maria , Tiwari Maneesh , Vallabh Jayesh
Published: June 2022

UNSTRUCTURED

A 73-year-old female presented with a 2-year history of intermittent pruritis along the neck and dorsolateral upper extremities. The patient never perceived pain in this area, but only severe pruritis which worsened in hot, sunny weather. Pruritis occurred in an episodic pattern, and symptoms improved with daily loratidine and bismuth subsalicyclate, for which she began to take prophylactically after her last episode. The patient reported no dermatological disease, familial pruritis, or trauma to the spine or extremities. Neurological exam was normal at the time of clinic visit, and magnetic resonance imaging (MRI) of the cervical spine demonstrated multilevel degenerative disease with bilateral neuroforaminal stenosis that was most severe at C4-C5 and C5-C6.
Research on the Impact of Inventory Management Practice on Organizational Performance in Telecommunication Companies
Authors: Kansime Kamugisha Derrick
Published: June 2022

Abstract: This research study examined the impact of inventory management on organizational performance in telecom companies. The study used a descriptive study design, and SPSS was used to conduct statistical analysis. In order to choose the samples, the researcher used both purposive and simplerandom sampling methods. Data for the study was collected from 130 respondents out of which 92 responded making the research valid. The relationships and hypothesis proposed in theconceptual framework were tested using multi-linear regression equation model. The research results indicate that higher levels of inventory management practice can lead to an enhanced competitive advantage and improved organizational performance. The study also accepted the hypothesis that was tested that inventory management and organizational performance have a significant positive relationship. Therefore, it is recommended that telecom organizations in Uganda should adopt Vendor management inventory, maintain good communication with the suppliers as this helps to eventually transfer inventory management responsibilities from the company’s procurement function to the vendors thus revamping organizational performance and increasing their competitiveness. They should also update their inventory management system in order to improve effectiveness by investing more money in the latest IT systems and utilizing sophisticated technologies such as purchasing fuel sensors for inventory monitoring and management so as to minimize on downtime and as well as cost reduction. The research study alsosuggests that management should take a more proactive approach to the problem of inappropriate inventory management strategies being used by constantly exposing its employees to training ona regular basis in order to strengthen their inventory management skills and allow them to understand current inventory management systems thus if implemented it can enable the companyin lowering costs by ensuring that stock records are maintained accurately and kept in order to prevent the risk of overstocking or understocking. Key words: Inventory management, Organizational Performance, Telecommunication companies
Role of Indian Microfinance Institutions in Financial Inclusions
Authors: Kauser Zeenat , Zubairi Dr. M. N.
Published: June 2022

Abstract: Microfinance growth is critical to the upliftment of financially excluded from the mainstream. This is evident from their contribution to improving financial inclusion particularly in semi urban and rural locations. Micro Finance players have been actively pursuing activities to balance social and commercial obligations and a key stakeholder in the process customers Financial Institutions and regulators. This paper highlights various aspects of growth of microfinance institution with a wide array of services in India that have consequently brought about significant changes in the lives of economically marginalized people and reduce vagaries of source of income. Keywords- Financial inclusions, microfinance institutions, outreach.
Identification of Groundwater Potential Zones Using Remote Sensing and GIS for Gautam Buddha Nagar
Authors: Tomar Kartikay , Tripathi Kaustubh , Tripathi Jeevesh , Maurya Devashish
Published: June 2022

Abstract: With an escalatory growth of human population in the 21st century there has been a significant increase in demand of water for human survival. With the limitation of Surface water sources now ground water that contributes to the total annual supply of water consumption and outshines as one of the major sources. The objective of this paper is to review and analyze the area of Gautam Buddh Nagar, Uttar Pradesh using remote sensing and Geographic Information System for identification of groundwater potential zones. There is various expertise which are used for different water zones for its mapping and its analysis. Parameters like density, soil, land use\cover, geology, drainage, rainfall, contour and terrain are used for controlling groundwater zones. These Groundwater mapping methods are explained and extracted from data sources of satellite images. These techniques include methods which are advance and conventional. For identification and mapping of groundwater potential analysis the thematic layers are used. The significance of each layer is discussed for the location groundwater potential zones using the conditions present. For effective exploration and identification of appropriate locations for water extraction this groundwater potential information will be helpful. For analysis exploration and study of a location remote sensing data is a fast, cost-effective and economical way of doing it. With the Integration of these data for the exploration of groundwater resources has been seen as a breakthrough in the field of its research, and plays a significant role for providing assistance in monitoring, accessing, and preservation of groundwater resources. In the present paper, the assessment of groundwater availability in Gautam Buddha Nagar, Uttar Pradesh, India have been conducted using these techniques. Various maps were prepared like base map, DEM, drainage density map, contour map, land use map, lineament density map and groundwater potential zones using the data of remote sensing and the existing maps. Raster data was transformed from base map and DEM using feature to raster converter tool in ArcGIS 10.3 version
Edukasi Hukum tentang Kekerasan Seksual Pada Perempuan Dan Anak Di Kelurahan Lateri Kota Ambon
Authors: Saimima Judy Marria , Liminanto Elvira , Wasia Zacilasi
Published: June 2022

Kekerasan seksual yang terjadi pada seorang perempuan dan anak dikarenakan sistem tata nilai yang mendudukan perempuan dan anak sebagai makhluk yang lemah dan lebih rendah dibandingkan laki-laki. Sangat diperlukan pemahaman hukum yang baik kepada masyarakat terkait kekerasan seksual agar mampu untuk bertindak ketika mengalami kekerasan seksual. Kegiatan ini dilakukan dengan mengidentifikasi masalah yang ada di daerah tersebut, kemudian masyarakat diberikan pemahaman demi meningkatkan kesadaran hukum tentang kekerasan seksual pada perempuan dan anak. Suatu perbuatan dapat dikategorikan sebagai kekerasan seksual adalah ketika perbuatan tersebut dilakukan tanpa ada persetujuan atau tidak dikehendaki. Undang-Undang PKDRT, UU Perlindungan Anak, KUHP bahkan UU Pornografi memang telah mengatur perlindungan bagi korban kekerasan seksual terhadap anak dan perempuan, namun itu belum cukup untuk bisa melindungi korban, karena perlindungan kekerasan seksual bukanlah terbatas pada teori dan peraturan tetapi lebih meluas lagi kepada kesadaran masyarakat sebagai makhluk sosial itu sendiri.   
 
Legal Education On Sexual Violence Against Women And Children In Lateri Village, Ambon City
Sexual violence that occurs to a woman and child is due to a value system that places women and children as weak and inferior beings compared to men. It is necessary to have a good legal understanding of the community regarding sexual violence so that they are able to act when experiencing sexual violence. This activity is carried out by identifying the problems that exist in the area, then the community is given an understanding in order to increase legal awareness about sexual violence against women and children. An act that can be categorized as sexual violence is when the act is carried out without consent or is not desired. The PKDRT Law, the Child Protection Law, the Criminal Code and even the Pornography Law have indeed regulated protection for victims of sexual violence against children and women, but that is not enough to protect victims, because sexual violence protection is not limited to theories and regulations but is more broadly applicable to awareness of society as a social being itself.
Sosialisasi Program Aplikasi SIMAM: Upaya Inventarisasi Aset Pimpinan Cabang Muhammadiyah Bululawang
Authors: Luthfi Muhammad , Hartini Rahayu
Published: June 2022

Muhammadiyah sebagai salah satu organisasi filantropi Islam dengan ragam aset yang dimiliki, mencanangkan program manajemen aset melalui aplikasi SIMAM, program ini menyasar seluruh aset yang berada pada setiap unsur pimpinan dan amal usaha yang dimiliki Muhammadiyah, berkenaan dengan hal tersebut maka dilakukan sosialiasi program aplikasi SIMAM di salah satu unsur pimpinan Muhammadiyah di kecamatan Bululawang. Tujuan pelaksanaan kegiatan, untuk memberikan pengetahuan dan pemahaman tentang program aplikasi SIMAM. Metode sosialisasi digunakan dalam kegiatan dengan pendekatan klasikal berupa pemberian pertanyaan pre-test, ceramah / presentasi, diskusi / tanya jawab, dan pemberian pertanyaan post-test. Hasil kegiatan menyatakan, sebelum kegiatan dilakukan Mitra kebanyakan belum mengatahui tentang program SIMAM hal ini diketahui dari hasil jawaban pre-test yang di berikan, berdasar dari hasil jawaban pre-test Tim Pengabdi memberikan 3 materi meliputi, konsep program SIMAM, tujuan program SIMAM, dan jenis kehartabendaan yang dimaukkan pada program SIMAM. Dampak kegiatan yang dihasilkan dari kegiatan ini Mitra mengetahui dan memahami program aplikasi SIMAM, hal ini di buktikan dengan jawaban dari pertanyaan post-test yang didapat Tim Pengabdi di mana seluruh peserta mengetahui dan memahami program aplikasi SIMAM.
 
SIMAM Application Program Socialization: Efforts to Inventory Assets for Muhammadiyah Bululawang Branch Managers
Muhammadiyah as one of the Islamic philanthropic organizations with a variety of assets owned, launched an asset management program through the SIMAM application, this program targets all assets located in every element of muhammadiyah's leadership and business charity, in this regard to this, the socialization of the SIMAM application program is carried out in one of the muhammadiyah leadership elements in Bululawang subdistrict. The purpose of carrying out activities, is to provide knowledge and understanding of the SIMAM application program. Socialization methods are used in activities with a classic approach in the form of giving pre-test questions, lectures/presentation, discussions / Q&A, and giving post-test questions. The results of the activity stated before the activity was carried out, most partners did not know about the SIMAM program, this was known from the results of the pre-test answers given, based on the results of the pre-test answers the Pengabdi Team gave 3 materials including, the concept of the SIMAM program, the purpose of the SIMAM program, and the type of treasures in the SIMAM program. The impact of the activities resulting from this activity, the Partner knows and understands the SIMAM application program, this is evidenced by the answers to post-test questions obtained by the Pengabdi Team where all participants know and understand the SIMAM application program.
Non-ergodic delocalized phase with Poisson level statistics
Authors: Tang Weichen , Khaymovich Ivan M.
Published: June 2022

Motivated by the many-body localization (MBL) phase in generic interacting disordered quantum systems, we develop a model simulating the same eigenstate structure like in MBL, but in the random-matrix setting. Demonstrating the absence of energy level repulsion (Poisson statistics), this model carries non-ergodic eigenstates, delocalized over the extensive number of configurations in the Hilbert space. On the above example, we formulate general conditions to a single-particle and random-matrix models in order to carry such states, based on the transparent generalization of the Anderson localization of single-particle states and multiple resonances.