bluuebunny/crossref_metadata_2025 huggingface dataset:
Effects of Preoperative Anxiety on Postoperative Outcomes and Sleep Quality in Patients Undergoing Laparoscopic Gynecological Surgery
Authors: Gu Xiangyi , Zhang Yufei , Wei Wenxin , Zhu Junchao
Published: February 2023

Objective: Preoperative anxiety is a psychological state that commonly occurs before surgery and may have a negative impact on postoperative outcomes. This study aimed to investigate the effects of preoperative anxiety on postoperative sleep quality and recovery outcomes among patients undergoing laparoscopic gynecological surgery. Methods: The study was conducted as a prospective cohort study. A total of 330 patients were enrolled and underwent laparoscopic gynecological surgery. After assessing the patient’s preoperative anxiety score on the APAIS scale, 100 patients were classified into the preoperative anxiety (PA) group (preoperative anxiety score > 10) and 230 patients into the non-preoperative-anxiety (NPA) group (preoperative anxiety score ≤ 10). The Athens Insomnia Scale (AIS) was assessed on the night before surgery (Sleep Pre 1), the first night after surgery (Sleep POD 1), the second night after surgery (Sleep POD2), and the third night after surgery (Sleep POD 3). Postoperative pain was evaluated by the Visual Analog Scale (VAS), and the postoperative recovery outcomes and adverse effects were also recorded. Result: The AIS score in the PA group was higher than that of the NPA group at Sleep-pre 1, Sleep POD 1, Sleep POD 2, and Sleep POD 3 (p < 0.05). The VAS score was higher in the PA group than in the NPA group within 48 h postoperatively (p < 0.05). In the PA group, the total dosage of sufentanil was significantly higher, and more rescue analgesics were required. Patients with preoperative anxiety showed a higher incidence of nausea, vomiting, and dizziness than those without preoperative anxiety. However, there was no significant difference in the satisfaction rate between the two groups. Conclusion: The perioperative sleep quality of patients with preoperative anxiety is worse than that of patients without preoperative anxiety. Moreover, high preoperative anxiety is related to more severe postoperative pain and an increased requirement for analgesia.
COVID-19 and Biomarkers: The Contribution of the Journal
Authors: Plebani Mario
Published: February 2023

Three years after coronavirus disease 2019 (COVID-19) was declared a pandemic by the World Health Organization (WHO), several features of the pathogenesis and innate immune response to SARS-CoV-2 (severe acute respiratory syndrome coronavirus disease 2) have now been clarified [...]
Giant Juvenile Fibroadenoma: Case Report and Review of the Literature
Authors: Eleftheriades Anna , Tsarna Ermioni , Toutoudaki Konstantina , Paschalidou Eleni , Christopoulos Nikolaos , Georgopoulos Ioannis , Mitropoulou Georgia , Christopoulos Panagiotis
Published: February 2023

Fibroadenomas are common benign breast tumors. Fibroadenomas that exceed 5 cm in diameter, weigh more than 500 g, or replace more than four-fifths of the breast are characterized as giant. A fibroadenoma diagnosed in patients during childhood or adolescence is characterized as juvenile. An extensive PubMed search of the literature in English up until August 2022 was performed. In addition, a rare case of a gigantic fibroadenoma in an 11-year-old premenarchal girl who was referred to our adolescent gynecology center is presented here. Eighty-seven cases of giant juvenile fibroadenomas have been reported in the literature along with our case. Patients with giant juvenile fibroadenoma presented at a mean age of 13.92 years and usually after menarche. Juvenile fibroadenomas are usually unilateral, occurring either in the right or the left breast; the majority of them are diagnosed when they are already more than 10 cm in size, and they are most frequently treated with total lump excision. Differential diagnosis includes phyllodes tumors and pseudo-angiomatous stromal hyperplasia. Conservative management is feasible, but surgical excision is recommended to patients with suspicious imaging features or when the mass grows rapidly.
Clinical Outcomes of the Intraocular Lens Injector and Busin Glide for Descemet Stripping Automated Endothelial Keratoplasty in Patients with Iridocorneal Endothelial Syndrome
Authors: Li Saiqing , Liu Zihao , Sun Binjia , Zhao Zelin , Wang Haiou , Zheng Qinxiang , Chen Wei
Published: February 2023

Purpose: To report the outcomes of Descemet stripping automated endothelial keratoplasty (DSAEK) performed in iridocorneal endothelial (ICE) syndrome patients using the intraocular lens injector (injector), in comparison with those using the Busin glide. Methods: In this retrospective, interventional comparative study, we evaluated the outcomes of DSAEK performed using the injector (n = 12) or the Busin glide (n = 12) for patients with ICE syndrome. Their graft position and postoperative complications were recorded. Their best-corrected visual acuity (BCVA) and endothelial cell loss (ECL) were monitored over a 12-month follow-up period. Results: DSAEK was conducted successfully in the 24 cases. The BCVA improved from the preoperative 0.99 ± 0.61 to 0.36 ± 0.35 at 12 months after operation (p < 0.001), with no significant difference between the two groups (the injector group and the Busin group) (p = 0.933). ECL at 1 month after DSAEK was 21.80 ± 15.01% in the injector group, which was significantly lower than 33.69 ± 9.75% of the Busin group (p = 0.031). No surgery-related complications were observed in the 24 cases intraoperatively or postoperatively except that one case suffered from postoperative graft dislocation, without statistical difference between the two groups. Conclusions: At 1 month after surgery, the use of graft injector for delivering DSAEK-based endothelial graft may cause significantly less endothelial cell damage than the pull-through technique used in the application of Busin glide. The injector allows safe endothelial graft delivery without the need of anterior chamber irrigation, which increases the ratio of successful graft attachment.
The Role of Diet during Pregnancy in Protecting against Gestational Diabetes Mellitus in a Population with Mediterranean Dietary Habits: A Cross-Sectional Study
Authors: Tsarna Ermioni , Eleftheriades Anna , Tsomi Efthymia , Ziogou Georgia , Vakas Panagiotis , Panoskaltsis Theodoros , Christopoulos Panagiotis
Published: February 2023

Gestational diabetes mellitus (GDM) is a common metabolic disorder among pregnant women. Dietary habits during pregnancy might alter the risk of GDM development, and populations following the Mediterranean diet are relatively understudied. This was a cross-sectional, observational study of 193 low-risk women admitted to a private maternity hospital in Greece to give birth. Food frequency data on specific food categories, selected based on previous research, were analyzed. Logistic regression models, both crude and adjusted for maternal age, body mass index before pregnancy, and gestational weight gain, were fitted. We observed no association of carbohydrate-rich meals, sweets, soft drinks, coffee, rice, pasta, bread and crackers, potatoes, lentils, and juices with GDM diagnosis. Cereals (crude p = 0.045, adjusted p = 0.095) and fruits and vegetables (crude p = 0.07, adjusted p = 0.04) appeared to have a protective effect against GDM, while frequent tea consumption was linked to higher risk of GDM development (crude p = 0.067, adjusted p = 0.035). These results strengthen previously identified associations and underline the importance and potential impact of changing dietary habits even during pregnancy in adjusting one’s risk of metabolic pregnancy complications, such as GDM. The importance of healthy dietary habits is highlighted, with the goal of raising awareness amongst obstetric care specialists regarding the provision of systematic nutrition recommendations to pregnant women.
The Impact of COVID-19 Pandemic First Wave on Healthcare Workers: A New Perspective from Qualifying PTSD Criterion A to Assessing Post-Traumatic Growth
Authors: Gesi Camilla , Cirnigliaro Giovanna , Achilli Francesco , Cerioli Matteo , Cafaro Rita , Boscacci Maria , Dell’Osso Bernardo
Published: February 2023

Post-traumatic growth (PTG) and specific traumatic events have been poorly explored in the literature focusing on post-traumatic stress disorder (PTSD) among healthcare workers (HWs) tackling the COVID-19 pandemic. In a large sample of Italian HWs, we investigated the kinds of traumatic events and whether PTG affects the risk of PTSD, along with its prevalence and features, during the first COVID-19 wave. COVID-19-related stressful events, Impact of Event Scale-Revised (IES-R) and PTG Inventory-Short Form (PTGI-SF) scores were collected through an online survey. Out of 930 HWs included in the final sample, 257 (27.6%) received a provisional PTSD diagnosis based on IES-R scores. Events referring to the overall pandemic (40%) and to a threat to a family member (31%) were reported as the most stressful events. Female sex, previous mental disorders, job seniority, unusual exposure to sufferance and experiencing a threat to one’s family significantly increased the provisional PTSD diagnosis’ risk, while being a physician, the availability of personal protective equipment and moderate/greater scores on the PTGI-SF spiritual change domain were found to be protective factors.
The Prevalence of Irritable Bowel Syndrome after Severe Acute Respiratory Syndrome Coronavirus 2 Infection and Their Association: A Systematic Review and Meta-Analysis of Observational Studies
Authors: Wang Ziyan , Peng Yinglong , Chen Minshan , Peng Liang , Huang Yongzhen , Lin Wei
Published: February 2023

Aim: Investigate the prevalence of irritable bowel syndrome (IBS) after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and assess the association between IBS and SARS-CoV-2 infection. Methods: A systematic literature search for PubMed, Web of Science, Embase, Scopus, and the Cochrane Library was performed to identify all reports published before 31 December 2022. The confidence interval (CI), estimation effect (ES) of prevalence, and risk ratios (RR) were calculated to evaluate the prevalence of IBS after SARS-CoV-2 infection and their association. Individual results were pooled by the random-effects (RE) model. Subgroup analyses conducted a further investigation of the results. We employed funnel plots, Egger’s test, and Begg’s test to evaluate publication bias. Sensitivity analysis was performed for the assessment of the robustness of the result. Results: The data on IBS prevalence after SARS-CoV-2 infection were extracted from two cross-sectional studies and ten longitudinal studies from nineteen countries with 3950 individuals. The IBS prevalence after SARS-CoV-2 infection ranges from 3% to 91% in different countries, and the overall pooled prevalence of IBS following SARS-CoV-2 infection is 15% (ES: 0.15; 95% CI, 0.11–0.20; p = 0.000). The data on the association between IBS and SARS-CoV-2 infection were extracted from six cohort studies from fifteen countries with 3595 individuals. The risk of IBS increased following SARS-CoV-2 infection but was not significant (RR: 1.82; 95% CI, 0.90–3.69; p = 0.096). Conclusions: In conclusion, the overall pooled prevalence of IBS following SARS-CoV-2 infection was 15%, and SARS-CoV-2 infection increased the overall risk of IBS but was not statistically significant. Further extra high-quality epidemiological evidence and studies to clarify the underlying mechanism of IBS following SARS-CoV-2 infection are needed.
Off-Hours versus Regular-Hours Implantation of Peripheral Venoarterial Extracorporeal Membrane Oxygenation in Patients with Cardiogenic Shock
Authors: Gómez-Sánchez Roberto , García-Carreño Jorge , Martínez-Solano Jorge , Sousa-Casasnovas Iago , Juárez-Fernández Miriam , Devesa-Cordero Carolina , Sanz-Ruiz Ricardo , Gutiérrez-Ibañes Enrique , Elízaga Jaime , Fernández-Avilés Francisco , Martínez-Sellés Manuel
Published: February 2023

Background. The “weekend effect” has been associated with worse clinical outcomes. Our aim was to compare off-hours vs. regular-hours peripheral venoarterial extracorporeal membrane oxygenation (VA-ECMO) in cardiogenic shock patients. Methods. We analyzed in-hospital and 90-day mortality among 147 consecutive patients treated with percutaneous VA-ECMO for medical reasons between July 1, 2013, and September 30, 2022, during regular-hours (weekdays 8:00 a.m.–10:00 p.m.) and off-hours (weekdays 10:01 p.m.–7:59 a.m., weekends, and holidays). Results. The median patient age was 56 years (interquartile range [IQR] 49–64 years) and 112 (72.6%) were men. The median lactate level was 9.6 mmol/L (IQR 6.2–14.8 mmol/L) and 136 patients (92.5%) had a Society for Cardiovascular Angiography and Interventions (SCAI) stage D or E. Cannulation was performed off-hours in 67 patients (45.6%). In-hospital mortality was similar in off-hours and regular hours (55.2% vs. 56.3%, p = 0.901), as was the 90-day mortality (58.2% vs. 57.5%, p = 0.963), length of hospital stay (31 days [IQR 16–65.8 days] vs. 32 days [IQR 18–63 days], p = 0.979), and VA-ECMO related complications (77.6% vs. 70.0%, p = 0.305). Conclusions. Off-hours and regular-hours percutaneous VA-ECMO implantation in cardiogenic shock of medical cause have similar results. Our results support well-designed 24/7 VA-ECMO implantation programs for cardiogenic shock patients.
Systematic Review and Meta-Analysis of Efficiency and Safety of Double-Lumen Tube and Bronchial Blocker for One-Lung Ventilation
Authors: Palaczynski Piotr , Misiolek Hanna , Szarpak Lukasz , Smereka Jacek , Pruc Michal , Rydel Mateusz , Czyzewski Damian , Bialka Szymon
Published: February 2023

One-lung ventilation is also used in some thoracic or cardiac surgery, vascular surgery and oesophageal procedures. We conducted a search of the literature for relevant studies in PubMed, Web of Science, Embase, Scopus and Cochrane Library. The final literature search was performed on 10 December 2022. Primary outcomes included the quality of lung collapse. Secondary outcome measures included: the success of the first intubation attempt, malposition rate, time for device placement, lung collapse and adverse events occurrence. Twenty-five studies with 1636 patients were included. Excellent lung collapse among DLT and BB groups was 72.4% vs. 73.4%, respectively (OR = 1.20; 95%CI: 0.84 to 1.72; p = 0.31). The malposition rate was 25.3% vs. 31.9%, respectively (OR = 0.66; 95%CI: 0.49 to 0.88; p = 0.004). The use of DLT compared to BB was associated with a higher risk of hypoxemia (13.5% vs. 6.0%, respectively; OR = 2.27; 95%CI: 1.14 to 4.49; p = 0.02), hoarseness (25.2% vs. 13.0%; OR = 2.30; 95%CI: 1.39 to 3.82; p = 0.001), sore throat (40.3% vs. 23.3%; OR = 2.30; 95%CI: 1.68 to 3.14; p < 0.001), and bronchus/carina injuries (23.2% vs. 8.4%; OR = 3.45; 95%CI: 1.43 to 8.31; p = 0.006). The studies conducted so far on comparing DLT and BB are ambiguous. In the DLT compared to the BB group, the malposition rate was statistically significantly lower, and time to tube placement and lung collapse was shorter. However, the use of DLT compared to BB can be associated with a higher risk of hypoxemia, hoarseness, sore throat and bronchus/carina injuries. Multicenter randomized trials on larger groups of patients are needed to draw definitive conclusions regarding the superiority of any of these devices.
Reverse Torque Value of Angulated Screw Channel Abutment before and after Cyclic Loading: An In Vitro Study
Authors: Chen Yu-Hsuan , Wu Yu-Ling , Chen Hung-Shyong , Lin Ching-Ping , Wu Aaron Yu-Jen
Published: February 2023

This in vitro experiment aimed to understand the difference in preload acting on an abutment screw under different angles of angulated screw-retained crown and the performance after cyclic loading. In total, thirty implants with angulated screw channel (ASC) abutments were divided into two parts. The first part consisted of three groups: a 0° access channel with a zirconia crown (ASC-0) (n = 5), a 15° access channel with a specially designed zirconia crown (sASC-15) (n = 5), and a 25° access channel with a specially designed zirconia crown (sASC-25) (n = 5). The reverse torque value (RTV) was measured at 0° for each specimen. The second part consisted of three groups: a 0° access channel with a zirconia crown (ASC-0) (n = 5); a 15° access channel with a zirconia crown (ASC-15) (n = 5), and a 25° access channel with a zirconia crown (ASC-25) (n = 5). The manufacturer’s recommended torque was applied to each specimen, and baseline RTV was measured before cyclic loading. Each ASC implant assembly was cyclically loaded at 0 to 40 N with 1 million cycles at 10 Hz. RTV was measured after cyclic loading. Kruskal–Wallis test and Jonckheere–Terpstra test were used for statistical analysis. All specimens were examined under a digital microscope and scanning electron microscope (SEM) to observe the wear of the screw head before and after the whole experiment. A significant difference in the different percentages of straight RTV (sRTV) between the three groups was found (p = 0.027). The angle of ASC to the different percentages of sRTV showed a significant linear trend (p = 0.003). No significant differences were found in RTV difference after cyclic loading among the ASC-0, ASC-15, and ASC-25 groups (p = 0.212). The ASC-25 group had the most serious degree of wear based on a digital microscope and SEM examination. The ASC angle will affect the actual preload acting on a screw: the larger the ASC angle, the smaller the preload. The performance of the angled ASC groups in RTV difference was comparable to that of 0° ASC after cyclic loading.
Titanium Lattice Structures Produced via Additive Manufacturing for a Bone Scaffold: A Review
Authors: Distefano Fabio , Pasta Salvatore , Epasto Gabriella
Published: February 2023

The progress in additive manufacturing has remarkably increased the application of lattice materials in the biomedical field for the fabrication of scaffolds used as bone substitutes. Ti6Al4V alloy is widely adopted for bone implant application as it combines both biological and mechanical properties. Recent breakthroughs in biomaterials and tissue engineering have allowed the regeneration of massive bone defects, which require external intervention to be bridged. However, the repair of such critical bone defects remains a challenge. The present review collected the most significant findings in the literature of the last ten years on Ti6Al4V porous scaffolds to provide a comprehensive summary of the mechanical and morphological requirements for the osteointegration process. Particular attention was given on the effects of pore size, surface roughness and the elastic modulus on bone scaffold performances. The application of the Gibson–Ashby model allowed for a comparison of the mechanical performance of the lattice materials with that of human bone. This allows for an evaluation of the suitability of different lattice materials for biomedical applications.
Epigenetic Differences Arise in Endothelial Cells Responding to Cobalt–Chromium
Authors: da C. Fernandes Célio Junior , da Silva Rodrigo A. Foganholi , de Almeida Gerson Santos , Ferreira Marcel Rodrigues , de Morais Paula Bertin , Bezerra Fábio , Zambuzzi Willian F.
Published: February 2023

Cobalt–chromium (Co-Cr)-based alloys are emerging with important characteristics for use in dentistry, but the knowledge of epigenetic mechanisms in endothelial cells has barely been achieved. In order to address this issue, we have prepared a previously Co-Cr-enriched medium to further treat endothelial cells (HUVEC) for up to 72 h. Our data show there is important involvement with epigenetic machinery. Based on the data, it is believed that methylation balance in response to Co-Cr is finely modulated by DNMTs (DNA methyltransferases) and TETs (Tet methylcytosine dioxygenases), especially DNMT3B and both TET1 and TET2. Additionally, histone compaction HDAC6 (histone deacetylase 6) seems to develop a significant effect in endothelial cells. The requirement of SIRT1 seems to have a crucial role in this scenario. SIRT1 is associated with a capacity to modulate the expression of HIF-1α in response to hypoxia microenvironments, thus presenting a protective effect. As mentioned previously, cobalt is able to prevent HIF1A degradation and maintain hypoxia-related signaling in eukaryotic cells. Together, our results show, for the first time, a descriptive study reporting the relevance of epigenetic machinery in endothelial cells responding to cobalt–chromium, and it opens new perspectives to better understand their repercussions as prerequisites for driving cell adhesion, cell cycle progression, and angiogenesis surrounding this Co-Cr-based implantable device.
Titanium-Enriched Medium Promotes Environment-Induced Epigenetic Machinery Changes in Human Endothelial Cells
Authors: Fernandes Célio Júnior da C. , da Silva Rodrigo A. Foganholi , Wood Patrícia F. , Ferreira Marcel Rodrigues , de Almeida Gerson S. , de Moraes Julia Ferreira , Bezerra Fábio J. , Zambuzzi Willian F.
Published: February 2023

It is important to understand whether endothelial cells are epigenetically affected by titanium-enriched media when angiogenesis is required during bone development and it is expected to be recapitulated during osseointegration of biomaterials. To better address this issue, titanium-enriched medium was obtained from incubation of titanium discs for up to 24 h as recommended by ISO 10993-5:2016, and further used to expose human umbilical vein endothelial cells (HUVECs) for up to 72 h, when the samples were properly harvested to allow molecular analysis and epigenetics. In general, our data show an important repertoire of epigenetic players in endothelial cells responding to titanium, reinforcing protein related to the metabolism of acetyl and methyl groups, as follows: Histone deacetylases (HDACs) and NAD-dependent deacetylase sirtuin-1 (Sirt1), DNA methyltransferases (DNMTs) and ten-eleven translocation (TET) methylcytosine dioxygenases, which in conjunction culminate in driving chromatin condensation and the methylation profile of DNA strands, respectively. Taking our data into consideration, HDAC6 emerges as important player of this environment-induced epigenetic mechanism in endothelial cells, while Sirt1 is required in response to stimulation of reactive oxygen species (ROS) production, as its modulation is relevant to vasculature surrounding implanted devices. Collectively, all these findings support the hypothesis that titanium keeps the surrounding microenvironment dynamically active and so affects the performance of endothelial cells by modulating epigenetics. Specifically, this study shows the relevance of HDAC6 as a player in this process, possibly correlated with the cytoskeleton rearrangement of those cells. Furthermore, as those enzymes are druggable, it opens new perspectives to consider the use of small molecules to modulate their activities as a biotechnological tool in order to improve angiogenesis and accelerate bone growth with benefits of a fast recovery time for patients.
Investigation of the Formability of Cryogenic Rolled AA6061 and Its Improvement Using Artificial Aging Treatment
Authors: Sadeghi Abbas , Kozeschnik Ernst , Biglari Farid R.
Published: February 2023

Cryogenic rolling is one of the essential severe plastic deformation processes to manufacture high-strength aluminum sheets with excellent formability limits. The present work characterizes the formability of AA6061 for cryogenic rolling before and after artificial aging. Nakajima method based on ISO standard is used to measure formability. Samples are aged in the range of 100 °C to 150 °C. Artificial aging at 150 °C is found to be the optimum temperature for achieving a good combination of strength and formability. Over the course of artificial aging, strength improved up to 40%, where the original value of 250 MPa for cryo-rolled condition increased to 350 MPa after 50 h of aging at 150 °C, and the formability of the cryo-rolled sample improved especially for multi-axial forming condition.
What Should We Pay More Attention to Marfan Syndrome Expecting Ectopia Lentis: Incidence and Risk Factors of Retinal Manifestations
Authors: Liu Yan , Chen Tianhui , Jiang Yongxiang
Published: February 2023

(1) Background: This paper investigates the incidence and risk factors of retinal manifestations in patients with Marfan syndrome (MFS) in a Chinese cohort. (2) Methods: This is a population-based cross-sectional study. In total, 344 eyes (172 MFS participants) were enrolled, each of whom underwent a detailed ocular examination. B-scan ultrasonography, ultra-wide-angle fundus images and optical coherence tomography images were conducted to assess posterior staphyloma, types of retinal damages and maculopathy. (3) Results: MFS patients have a high proportion (32.5%) of maculopathy, among which atrophy is the most common type (27.6%). Compared with participants without maculopathy, participants with maculopathy had a longer axial length (AL), higher incidence of posterior staphyloma, macular split and retinal detachment (RD) (p < 0.001, p < 0.001, p < 0.001 and p = 0.001). Moreover, the stage of RD has a significant correlation with longer AL and shallower anterior chamber depth (ACD) (p = 0.001 and p = 0.034, respectively). (4) Conclusions: A higher incidence and earlier onset of fundus lesions were found in MFS patients. Yearly systematic examination is recommended for MFS children with fundus manifestation until the cardiovascular and skeletal development is complete.
A Summary on Tuberculosis Vaccine Development—Where to Go?
Authors: Jiang Fan , Sun Tiehui , Cheng Peng , Wang Jie , Gong Wenping
Published: February 2023

Background: Tuberculosis (TB) is an old infectious disease caused by Mycobacterium tuberculosis infection. Vaccination is the most effective way to prevent and control TB. However, there is relatively little literature that systematically analyzes the progress of new TB vaccine research from a bibliometric perspective. This study was conducted to examine the development of TB vaccines over the past 20 years and to identify research priorities and directions for the future. Methods: The Science Citation Index Expanded (SCI-E) of the Web of Science Core Collection (WOSCC) database was selected to search the literature related to TB vaccines. The countries, institutions, authors, journals, references, and keywords of each publication were analyzed and visualized using the VOSviewer, CiteSpace, and Bibliometrix software. Furthermore, GraphPad Prism and Microsoft Excel 365 were also used for statistical analysis. Results: As of 20 October 2022, 7960 publications related to TB vaccines were identified with 288,478 citations. The United States of America (USA) accounted for the largest share (2658, 33.40%), followed by the United Kingdom (UK, 1301, 16.34%), and China (685, 8.6%). Regarding affiliations, the University of London had the most publications (427) and shared the highest H-index (76) with the Statens Serum Institut of Denmark. In terms of the number of articles for the journals and authors, the journal Vaccine ranked first with 629 articles. Professor Peter Anderssen has published the highest number of papers (160). The burst keywords and thematic maps analysis showed that future trends in TB vaccine development would focus on exploring the interaction mechanisms between M. tuberculosis and the host. Conclusion: The number of publications on TB vaccines has grown over the past two decades. Developed countries play a significant role in TB vaccine research, and developing countries are fast catching up. We believe that future research will be aimed at understanding the fine molecular mechanisms of host–pathogen interaction, leading to the development of better TB vaccines.
A Modified Technique for Preventing Lens–Iris Diaphragm Retropulsion Syndrome in Vitrectomized Eyes during Phacoemulsification
Authors: Wu Zhiyi , He Tian , Su Zhitao , Liu Ye , He Jingliang , Huo Yanan
Published: February 2023

Background: Lens–iris diaphragm retropulsion syndrome (LIDRS) is common in vitrectomized or high myopic eyes during phacoemulsification. We evaluated the results of a modified technique for cataract treatment using phacoemulsification in vitrectomized eyes. Methods: In this retrospective study, we enrolled thirty-four vitrectomized eyes treated with modified phacoemulsification (Modified Group) and nineteen vitrectomized eyes treated with routine phacoemulsification (Control Group). The modified technique comprised irrigation with a balanced salt solution underneath the pupil before phacoemulsification instrument entry, lens implantation and stromal hydration to stabilize the anterior chamber and equilibrate the pressure between the anterior chamber and posterior cavity. Results: We compared the incidences of intra and postoperative complications and visual outcomes between modified and routine phacoemulsification. Pain, LIDRS and difficulty in stromal hydration were significantly more common in the Control Group than in the Modified Group (p < 0.05). There were no significant differences in the rates of posterior capsular rupture, iris trauma, lens dislocation, or posterior capsular opacification between the Modified and Control Groups (p > 0.05). However, there was no significant difference in visual acuity between the groups (p > 0.05). Complications such as loss of nuclear fragments into the vitreous cavity, cystoid macular edema, retina redetachment, suprachoroidal hemorrhage and vitreous hemorrhage did not occur either intra or postoperatively in any of our patients. Conclusions: Our modified technique prevents LIDRS and complications arising during cataract surgery in vitrectomized eyes. Aside from this, the results of modified and routine phacoemulsification are similar in vitrectomized eyes.
Patient Satisfaction with a Dedicated Infusion Pump for Subcutaneous Treprostinil to Treat Pulmonary Arterial Hypertension
Authors: Waligóra Marcin , Żuławinska Barbara , Tomaszewski Michał , Roset Pere , Kopeć Grzegorz
Published: February 2023

Background and Objectives: Parenteral prostacyclins are crucial in the pharmacological treatment of pulmonary arterial hypertension (PAH). Indeed, subcutaneous administration of treprostinil has been associated with considerable clinical and hemodynamic improvement, right-sided heart reverse remodeling, and long-term survival benefit. However, evidence on patient perceptions about handling a subcutaneous infusion pump for self-treatment administration and nurse views about training the patients are lacking. This study aimed to describe the perception of PAH patients and nurses regarding the use of the new portable I-Jet infusion pump for the self-administration of subcutaneous treprostinil, as well as its real-world training needs. Materials and Methods: The study is an open, observational, prospective, single-center, non-interventional study. Patients with PAH on stable therapy with subcutaneous treprostinil were invited to take part in the study at their start of use of the portable I-Jet infusion pump for the self-administration of treatment. Participants filled in a questionnaire to report their satisfaction with the use of the pump, as well as their compliance, confidence, convenience, preferences, technical issues, and perceptions of the training they received. Results: Thirteen patients completed the questionnaire after being on the pump for 2 months: 69% were females and the mean age was 51 years. The most frequent PAH etiologies were congenital heart disease (46.2%) and idiopathic PAH (38.4%). Most patients were either World Health Organization (WHO) functional class II (53.8%) or III (46.2%). Ten patients (76.9%) found the pump easy and convenient to live with. All patients declared themselves to be fully compliant and confident in using the pump (n = 13) at the end of the study follow-up. Ten patients (76.9%) would choose the new pump in the future. None of the patients made reference to technical issues that required additional hospital visits. Eight patients (61.6%) reported that learning how to use the I-Jet infusion pump was easy or very easy, and none considered that further training was needed. One trainer nurse was interviewed and confirmed the satisfaction of patients and the simplicity of usage and training. Conclusions: PAH patients were highly satisfied with the use of the new portable I-Jet infusion pump for self-administering subcutaneous treprostinil. Convenience and ease of use were valuable and commonly reported features. Moreover, the training requirement was simple. These preliminary findings support the routine use of the I-Jet infusion pump.
The Mineral Biochar Alters the Biochemical and Microbial Properties of the Soil and the Grain Yield of Hordeum vulgare L. under Drought Stress
Authors: Nasiri Sajjad , Andalibi Babak , Tavakoli Afshin , Delavar Mohammad Amir , El-Keblawy Ali , Zwieten Lukas Van , Mastinu Andrea
Published: February 2023

Biochar improves soil physical, biochemical, and microbial properties, leading to the amelioration of soil fertility, which, in turn, results in better growth and yield in crop plants. The current study aimed to evaluate whether using different levels of biochar can enhance soil characteristics and plant attributes. Accordingly, an experimental study was conducted in 2022 using a randomized complete block design with four replications (n = 4) in the experimental glasshouse of the University of Zanjan, in which two regimes of irrigation (D0, full irrigation as the control; D1, water scarcity was applied immediately after the flowering stage for two weeks) and four levels of natural mineral biochar (0% as the control treatment, 0.25, 0.5, and 1% of soil weight) were applied. The results indicated that drought substantially decreased the organic carbon content of the soil and the grain yield while increasing the available phosphorous, soil carbohydrate content, and microbial biomass of the soil. Biochar could considerably alter the means of the studied soil quality parameters and the barley grain yield. Adding biochar could be considered a valid strategy to increase the resistance of plants to drought.
New Absolute Chronological Constraints to La Playa (Sonoran Desert) Archaeology between the American Southwest and Mesoamerica—From Long Period Human Resilience to Apparent Abandonment
Authors: Goguitchaichvili Avto , Villapando Elisa , Abrego Alejandra , Cejudo Rubén , Kravchinsky Vadim , Bautista Francisco , García Karla Flores , Morales Juan , Cervantes Miguel
Published: February 2023

Sonoran Desert archaeological settlement is one of the most representative sites in Northwestern Mexico/Southwestern United States of the Early Agriculture period because of various cultural processes involved, such as the introduction of the first cultigens and the construction of Pit Houses. These early desert village settlements used geomorphological features of the local landscape to facilitate their sophisticated form of agriculture. Most of the features and artifacts at the site are associated with the Early Agricultural period of 3150-1900 cal B.P., while most occupation dates are in the Cienega phase (2800-1900 cal B.P.). Later stages are poorly documented because of the apparent reduction in population, less marked archaeological features, and extreme erosion processes. Systematic archaeological excavation revealed evidence of completely burned Pit Houses. We analyzed 56 samples belonging to four Pit Houses and one different combustion feature (Kiln or Horno, as they are locally known) in different areas of the settlement. The experimental procedure included continuous susceptibility vs. temperature measurements and step-wise alternating field demagnetizations. Only 36 samples yielded technically acceptable determinations that allowed the determination of archaeomagnetic directions. Statistically indistinguishable results were obtained from all five studied features. This finding reinforces archaeological evidence of ritual-related paraphernalia and/or apparent abandonment or, at least, migration.
Does an Association among Sarcopenia and Metabolic Risk Factors Exist in People Older Than 65 Years? A Systematic Review and Meta-Analysis of Observational Studies
Authors: Carcelén-Fraile María del Carmen , Aibar-Almazán Agustín , Afanador-Restrepo Diego Fernando , Rivas-Campo Yulieth , Rodríguez-López Carlos , Carcelén-Fraile María del Mar , Castellote-Caballero Yolanda , Hita-Contreras Fidel
Published: February 2023

Sarcopenia is defined as the generalized and progressive loss of skeletal muscle strength and mass that may be affected by metabolic factors, although this relationship has been poorly studied. The aim of this review and meta-analysis was to analyze the relationship among the different metabolic risk factors and sarcopenia in people older than 65 years. Following the PRISMA 2020 guide, we searched for articles that studied the relationship among sarcopenia and metabolic risk factors in adults over 65 years of age, published between 2012 and 2022 in four databases: PubMed, Web of Science, Cochrane Plus, and CINAHL. A total of 370 articles were identified in the initial search, of which 13 articles were selected for inclusion in this review. It was observed that metabolic risk factors such as Body Mass Index, systolic and diastolic blood pressure, glucose, cholesterol, or triglycerides had a significant association with sarcopenia. There is evidence of the association of different metabolic risk factors with sarcopenia in adults over 65 years of age, so it is necessary to carry out studies that investigate different strategies that reduce the appearance of sarcopenia, and with it, the incidence of metabolic diseases.
The Role of Dietary Fats in the Development and Treatment of Endometriosis
Authors: Marcinkowska Angelika , Górnicka Magdalena
Published: February 2023

Endometriosis is an estrogen-dependent disease in women of childbearing age that affects approximately 5–15% of the female population. The etiology of endometriosis is complex, multifaceted, and not fully understood. In endometriosis, which is an estrogen-related chronic inflammatory condition, estrogen plays a major role in endometrial cellular growth. High estrogen levels could be another risk factor for developing endometriosis. The aim of this review is to update knowledge on the impact of dietary fats on the development of endometriosis and chronic inflammation in women with endometriosis and diet therapy. Dietary fat may be linked with the progression and development of endometriosis, but studies have been contradictory due to various issues including sample size, different study designs, and different methodological aspects. Results have shown that the risk of endometriosis may increase with a higher consumption of products rich in saturated fats, especially palmitic acid and trans-unsaturated fatty acids. Monounsaturated fats and omega-3 polyunsaturated fatty acids may likely be connected with a lower risk of developing endometriosis and with reductions in the severity of disease. Monounsaturated fats, omega-3 polyunsaturated fatty acids, and a suitable eicosapentaenoic acid to arachidonic acid ratio can be used in diet therapy to improve quality of life by reducing pain and inflammation. Further research is needed in order to fully understand the influence of dietary fats on the risk of development of this disease.
Comparative Evaluation of the Shear Adhesion Strength of Ice on PTFE Solid Lubricant
Authors: Farahani Emad , Liberati Andre C. , Moreau Christian , Dolatabadi Ali , Stoyanov Pantcho
Published: February 2023

The development of a durable and green icephobic coating plays a vital role in the aviation industry due to the adverse impact of ice formation on aircraft performance. The lack of study into how temperature and surface roughness impact icephobicity is the main problem with present icephobic coatings. This study aims to qualitatively evaluate the icephobicity performance of a polytetrafluoroethylene (PTFE) solid lubricant film, as an environmentally friendly solution, with a custom-built push-off test device in different icing conditions utilizing a wind tunnel. The ice-adhesion reduction factor (ARF) of the film has been assessed in comparison to a bare aluminium substrate (Al 6061). The impact of surface energy was investigated by comparing the water contact angle (WCA), the contact angle hysteresis (CAH), and the pull-off force of the PTFE solid lubricant and Al with an atomic force microscope (AFM). The results of ice shear adhesion on the PTFE solid lubricant film showed a significant reduction in the ice adhesion force at various substrate temperatures and surface roughness compared to the bare aluminium substrate. The difference in the ice adhesion between the solid lubricant and aluminium alloy was attributed to the differences in the detachment mechanism. For the PTFE-based solid lubricant, the interfacial detachment mechanism was based on the formation of interfacial blisters towards the centre of the ice. Consequently, upon continued application of the shear force, most of the energy injected would be distributed throughout the blisters, ultimately causing detachment. In the comparison of ice adhesion on PTFE solid lubricant and bare aluminium, the film showed minimal ice adhesion at −6 °C with an adhesion force of 40 N (ARF 3.41). For temperature ranges between −2 °C and −10 °C, the ice adhesion for bare aluminium was measured at roughly 150 N.
Static Analysis of Wooden Beams Strengthened with FRCM-PBO Composite in Bending
Authors: Sokołowski Piotr Kazimierz , Kossakowski Paweł Grzegorz
Published: February 2023

The article presents an analysis of the static work of bent solid-wood beams reinforced with FRCM–PBO (fiber-reinforced cementitious matrix–p-phenylene benzobis oxazole) composite. In order to ensure better adhesion of the FRCM–PBO composite to the wooden beam, a layer of mineral resin and quartz sand was applied between the composite and the wooden beam. Ten wooden pine beams with dimensions of 80 × 80 × 1600 mm were used for the tests. Five wooden beams, unreinforced, were used as referenced elements and another five were reinforced with FRCM–PBO composite. The tested samples were subjected to a four-point bending test in which the static scheme of a simply supported beam subjected to two symmetrical concentrated forces was used. The main purpose of the experiment was to estimate the load capacity, the flexural modulus and the maximum bending stress. The time needed to destroy the element and the deflection were also measured. The tests were carried out based on the PN-EN 408: 2010 + A1 standard. The material used for the study was also characterized. The methodology and assumptions adopted in the study were presented. The tests confirmed a significant increase in destructive force by 141.46%, maximum bending stress by 118.9%, modulus of elasticity by 18.32%, time needed to destroy the sample by 106.56% and deflection by 115.58% compared to the reference beams. The unusual method of wood reinforcement presented in the article can be considered as innovative, characterized not only by a significant load capacity margin exceeding 141%, but also by simplicity of application.
Investigation of Frequency-Domain Dimension Reduction for A2M-Based Bridge Damage Detection Using Accelerations of Moving Vehicles
Authors: Li Zhenkun , Lan Yifu , Lin Weiwei
Published: February 2023

Recent decades have witnessed a rise in interest in bridge health monitoring utilizing the vibrations of passing vehicles. However, existing studies commonly rely on constant speeds or tuning vehicular parameters, making their methods challenging to be used in practical engineering applications. Additionally, recent studies on the data-driven approach usually need labeled data for damage scenarios. Still, getting these labels in engineering is difficult or even impractical because the bridge is typically in a healthy state. This paper proposes a novel, damaged-label-free, machine-learning-based, indirect bridge-health monitoring method named the assumption accuracy method (A2M). Initially, the raw frequency responses of the vehicle are employed to train a classifier, and K-folder cross-validation accuracy scores are then used to calculate a threshold to specify the bridge’s health state. Compared to merely focusing on low-band frequency responses (0–50 Hz), utilizing full-band vehicle responses can significantly improve the accuracy, meaning that the bridge’s dynamic information exists in the higher frequency ranges and can contribute to detecting bridge damage. However, raw frequency responses are generally in a high-dimensional space, and the number of features is much greater than that of samples. To represent the frequency responses via latent representations in a low-dimension space, appropriate dimension-reduction techniques are therefore, needed. It was found that principal component analysis (PCA) and Mel-frequency cepstral coefficients (MFCCs) are suitable for the aforementioned issue, and MFCCs are more damage-sensitive. When the bridge is in a healthy condition, the accuracy values obtained using MFCCs are primarily dispersed around 0.5, but following the occurrence of damage, they increased significantly to 0.89–1.0 in this study.
Process Parameter Investigation and Torsional Strength Analysis of the Additively Manufactured 3D Structures Made of 20MnCr5 Steel
Authors: Sarzyński Bartłomiej , Kluczyński Janusz , Łuszczek Jakub , Grzelak Krzysztof , Szachogłuchowicz Ireneusz , Torzewski Janusz , Śnieżek Lucjan
Published: February 2023

An ongoing growth of the available materials dedicated to additive manufacturing (AM) significantly extends the possibilities of their usage in many applications. A very good example is 20MnCr5 steel which is very popular in conventional manufacturing technologies and shows good processability in AM processes. This research takes into account the process parameter selection and torsional strength analysis of AM cellular structures. The conducted research revealed a significant tendency for between-layer cracking which is strictly dependent on the layered structure of the material. Additionally, the highest torsional strength was registered for specimens with a honeycomb structure. To determine the best-obtained properties, in the case of the samples with cellular structures, a torque-to-mass coefficient was introduced. It indicated the best properties of honeycomb structures, which have about 10% smaller torque-to-mass coefficient values than monolithic structures (PM samples).
Effect of In Situ Mg-Sialon on the Oxidation Behavior of Low-Carbon MgO-C Refractories
Authors: Dong Bo , Yu Chao , Xing Guangchao , Di Jinghui , Ding Jun , Zhu Qingyou , Zhu Hongxi , Deng Chengji
Published: February 2023

The in situ Mg-sialon in low-carbon MgO-C refractories was studied with respect to its oxidation behavior and mechanism at 1500 °C. The results indicated that the oxidation index and rate constant of low-carbon MgO-C refractories with Mg-sialon were 26.2% and 0.51 × 10−3 cm2/min at 1500 °C for 2 h, respectively. The formation of a dense MgO-Mg2SiO4-MgAl2O4 protective layer contributed to considerable oxidation resistance, and the generation of this thicker layer was due to the combined volume effect of Mg2SiO4 and MgAl2O4. The reduced porosity and more complex pore structure were also found in the refractories with Mg-sialon. Therefore, further oxidation was restricted as the oxygen diffusion path was effectively blocked. This work proves the potential application of Mg-sialon in improving the oxidation resistance of low-carbon MgO-C refractories.