bluuebunny/crossref_metadata_2025 huggingface dataset:
Numerical Modeling on the Compliance and Load Capacity of a Two-Row Aerostatic Journal Bearing with Longitudinal Microgrooves in the Inter-Row Zone
Authors: Kodnyanko Vladimir , Shatokhin Stanislav , Kurzakov Andrey , Pikalov Yuri , Pikalov Iakov , Grigorieva Olga , Strok Lilia , Brungardt Maxim
Published: June 2021

Aerostatic bearings are attractive, with minimal friction losses, high durability, and environmental friendliness. However, such designs have a number of disadvantages, including low load-bearing capacity and high compliance due to high air compressibility and limited injection pressure. The article proposes a double-row aerostatic journal bearing with an external combined throttling system and longitudinal microgrooves in the inter-row zone. It is hypothesized that the use of microgrooves will reduce the circumferential flows of compressed air, as a result of which the compliance should decrease and the bearing capacity should increase. To test the hypothesis, we carried out the mathematical modeling, calculations, and theoretical study of stationary operation modes of the bearing for small shaft eccentricities in the vicinity of the central equilibrium position of the shaft and bearing capacity for arbitrary eccentricities. Formulas were obtained for the numerical evaluation of compliance for bearings with a smooth bushing surface and with longitudinal microgrooves. Iterative finite-difference methods for evaluating the fields of the squared pressure are proposed, on the basis of which the load capacity of the bearings is calculated. Experimental verification of the bearing’s theoretical characteristics was carried out, which showed satisfactory agreement between the compared data. The study of the compliance and load capacity of a microgroove bearing yielded impressive results. We show that the positive effect from the application of the improvement begins to manifest itself already at four microgrooves; the effect becomes significant at six microgrooves, and at twelve or more microgrooves, the circumferential flows in the bearing gap practically disappear; therefore, the bearing characteristics can be calculated on the basis of one-dimensional models of air lubrication longitudinal flow. Calculations have shown that for a length of L = 1, the maximum load capacity of a bearing with microgrooves is 1.5 times higher than that of a conventional bearing; for L ≥ 1.5, the bearing capacity increases twice or more. The result obtained allows us to recommend the proposed improvement for practical use in order to increase the load capacity of aerostatic journal bearings significantly.
Quantifying Air Pollutant Variations during COVID-19 Lockdown in a Capital City in Northwest China
Authors: Feng Rong , Xu Hongmei , Wang Zexuan , Gu Yunxuan , Liu Zhe , Zhang Haijing , Zhang Tian , Wang Qiyuan , Zhang Qian , Liu Suixin , Shen Zhenxing , Wang Qin
Published: June 2021

In the context of the outbreak of coronavirus disease 2019 (COVID-19), strict lockdown policies were implemented to control nonessential human activities in Xi’an, northwest China, which greatly limited the spread of the pandemic and affected air quality. Compared with pre-lockdown, the air quality index and concentrations of PM2.5, PM10, SO2, and CO during the lockdown reduced, but the reductions were not very significant. NO2 levels exhibited the largest decrease (52%) during lockdown, owing to the remarkable decreased motor vehicle emissions. The highest K+ and lowest Ca2+ concentrations in PM2.5 samples could be attributed to the increase in household biomass fuel consumption in suburbs and rural areas around Xi’an and the decrease in human physical activities in Xi’an (e.g., human travel, vehicle emissions, construction activities), respectively, during the lockdown period. Secondary chemical reactions in the atmosphere increased in the lockdown period, as evidenced by the increased O3 level (increased by 160%) and OC/EC ratios in PM2.5 (increased by 26%), compared with pre-lockdown levels. The results, based on a natural experiment in this study, can be used as a reference for studying the formation and source of air pollution in Xi’an and provide evidence for establishing future long-term air pollution control policies.
The Dichotomy between Indoor Air Quality and Energy Efficiency in Light of the Onset of the COVID-19 Pandemic
Authors: Settimo Gaetano , Avino Pasquale
Published: June 2021

Recently, there has been a great increase in the importance of issues related to energy efficiency [...]
Observations of Atmospheric Aerosol and Cloud Using a Polarized Micropulse Lidar in Xi’an, China
Authors: Chen Chao , Song Xiaoquan , Wang Zhangjun , Wang Wenyan , Wang Xiufen , Zhuang Quanfeng , Liu Xiaoyan , Li Hui , Ma Kuntai , Li Xianxin , Pan Xin , Zhang Feng , Xue Boyang , Yu Yang
Published: June 2021

A polarized micropulse lidar (P-MPL) employing a pulsed laser at 532 nm was developed by the Institute of Oceanographic Instrumentation, Qilu University of Technology (Shandong Academy of Sciences). The optomechanical structure, technical parameters, detection principle, overlap factor calculation method, and inversion methods of the atmospheric boundary layer (ABL) depth and depolarization ratio (DR) were introduced. Continuous observations using the P-MPL were carried out at Xi’an Meteorological Bureau, and the observation data were analyzed. In this study, we gleaned much information on aerosols and clouds, including the temporal and spatial variation of aerosols and clouds, aerosol extinction coefficient, DR, and the structure of ABL were obtained by the P-MPL. The variation of aerosols and clouds before and after a short rainfall was analyzed by combining time-height-indication (THI) of range corrected signal (RCS) and DR was obtained by the P-MPL with profiles of potential temperature (PT) and relative humidity (RH) detected by GTS1 Digital Radiosonde. Then, the characteristics of tropopause cirrus cloud were discussed using the data of DR, PT, and RH. Finally, a haze process from January 1st to January 5th was studied by using aerosol extinction coefficients obtained by the P-MPL, PT, and RH profiles measured by GTS1 Digital Radiosonde and the time-varying of PM2.5 and PM10 observed by ambient air quality monitor. The source of the haze was simulated by using the NOAA HYSPLIT Trajectory Model.
Can a Warm Ocean Feature Cause a Typhoon to Intensify Rapidly?
Authors: Oey Leo , Huang Shimin
Published: June 2021

The hypothesis that a warm ocean feature (WOF) such as a warm eddy may cause a passing typhoon to undergo rapid intensification (RI), that is, the storm’s maximum 1-min wind speed at 10-m height increases by more than 15.4 m/s in 1 day, is of interest to forecasters. Testing the hypothesis is a challenge, however. Besides the storm’s internal dynamics, typhoon intensity depends on other environmental factors such as vertical wind shear and storm translation. Here we designed numerical experiments that exclude these other factors, retaining only the WOF’s influence on the storm’s intensity change. We use a storm’s translation speed Uh = 5 m/s when surface cooling is predominantly due to 1D vertical mixing. Observations have shown that the vast majority (70%) of RI events occur in storms that translate between 3 to 7 m/s. We conducted a large ensemble of twin experiments with and without ocean feedback and with and without the WOF to estimate model uncertainty due to internal variability. The results show that the WOF increases surface enthalpy flux and moisture convergence in the storm’s core, resulting in stronger updrafts and intensity. However, the intensification rate is, in general, insufficiently rapid. Consequently, the number of RIs is not statistically significantly different between simulations with and without the WOF. An analytical coupled model supports the numerical findings. Furthermore, it shows that WOF-induced RI can develop only over eddies and ambient waters that are a few °C warmer than presently observed in the ocean.
Influence of Heart Rate Variability on Abstinence-Related Changes in Brain State in Everyday Drinkers
Authors: Peterson Hope , Mayhugh Rhiannon , Bahrami Mohsen , Rejeski Walter , Simpson Sean , Heilman Keri , Porges Stephen , Laurienti Paul
Published: June 2021

Alcohol consumption is now common practice worldwide, and functional brain networks are beginning to reveal the complex interactions observed with alcohol consumption and abstinence. The autonomic nervous system (ANS) has a well-documented relationship with alcohol use, and a growing body of research is finding links between the ANS and functional brain networks. This study recruited everyday drinkers in an effort to uncover the relationship between alcohol abstinence, ANS function, and whole brain functional brain networks. Participants (n = 29), 24–60 years-of-age, consumed moderate levels of alcohol regularly (males 2.4 (±0.26) drinks/day, females 2.3 (±0.96) drinks/day). ANS function, specifically cardiac vagal tone, was assessed using the Porges-Bohrer method for calculating respiratory sinus arrhythmia (PBRSA). Functional brain networks were generated from resting-state MRI scans obtained following 3-day periods of typical consumption and abstinence. A multi-task mixed-effects regression model determined the influences of HRV and drinking state on functional network connectivity. Results showed differences in the relationship between the strength of network connections and clustering coefficients across drinking states, moderated by PBRSA. Increases in connection strength between highly clustered nodes during abstinence as PBRSA increases demonstrates a greater possible range of topological configurations at high PBRSA values. This novel finding begins to shed light on the complex interactions between typical alcohol abstinence and physiological responses of the central and autonomic nervous system.
Understanding the Clinical Impact of MUC5AC Expression on Pancreatic Ductal Adenocarcinoma
Authors: Manne Ashish , Esnakula Ashwini , Abushahin Laith , Tsung Allan
Published: June 2021

Mucin-5AC (MUC5AC) is a heavily glycosylated gel-forming secreted mucin with a reliable prognostic value when detected in multiple malignancies. It is highly prevalent (70%) in PDA and is nonexistent in normal pancreatic tissues. Retrospective studies on PDA tumor tissue (detected by immunohistochemistry or IHC)) have investigated the prognostic value of MUC5AC expression but were equivocal. Some studies associated it with poor outcomes (survival or pathological features such as lymph node disease, vascular/neural invasion in resected tumors), while others have concluded that it is a good prognostic marker. The examination of expression level threshold (5%, 10%, or 25%) and the detected region (apical vs. cytoplasmic) were variable among the studies. The maturation stage and glycoform of MUC5AC detected also differed with the Monoclonal antibody (Mab) employed for IHC. CLH2 detects less mature/less glycosylated versions while 45M1 or 21-1 detect mature/more glycosylated forms. Interestingly, aberrantly glycosylated variants of MUC5AC were detected using lectin assays (Wheat Germ Agglutinin-MUC5AC), and Mabs such as NPC-1C and PAM4 have are more specific to malignant pancreatic tissues. NPC-1C and PAM4 antibody reactive epitopes on MUC5AC are immunogenic and could represent specific changes on the native MUC5AC glycoprotein linked to carcinogenesis. It was never studied to predict treatment response.
Microbiota Alterations in Precancerous Colon Lesions: A Systematic Review
Authors: Aprile Francesca , Bruno Giovanni , Palma Rossella , Mascellino Maria Teresa , Panetta Cristina , Scalese Giulia , Oliva Alessandra , Severi Carola , Pontone Stefano
Published: June 2021

Gut microbiota plays an important role in human health. It may promote carcinogenesis and is related to several diseases of the gastrointestinal tract. This study of microbial dysbiosis in the etiology of colorectal adenoma aimed to investigate the possible causative role of microbiota in the adenoma–carcinoma sequence and its possible preventive role. A systematic, PRISMA-guided review was performed. The PubMed database was searched using “adenoma microbiota” and selecting original articles between January 2010 and May 2020 independently screened. A higher prevalence of Proteobacteria, Fusobacteria, and Bacteroidetes phyla was observed in the fecal luminal and mucosa-associated microbiota of patients with adenoma. However, other studies provided evidence of depletion of Clostridium, Faecalibacterium, Bacteroides and Romboutsia. Results on the relationship between adenoma endoscopic resection and microbiota were inconsistent. In conclusion, none of the analyzed studies developed a predictive model that could differentiate adenoma from non-adenoma patients, and therefore, to prevent cancer progression. The impact of adenoma’s endoscopic resection on microbiota was investigated, but the results were inconclusive. Further research in the field is required.
NGS-Based Analysis of Atypical Deep Penetrating Nevi
Authors: Manca Antonella , Sini Maria Cristina , Cesinaro Anna Maria , Portelli Francesca , Urso Carmelo , Lentini Maria , Cardia Roberta , Alos Llucia , Cook Martin , Simi Sara , Paliogiannis Panagiotis , De Giorgi Vincenzo , Cossu Antonio , Palmieri Giuseppe , Massi Daniela
Published: June 2021

Deep penetrating nevi (DPNs) are rare melanocytic neoplasms consisting of pigmented spindled or epithelioid melanocytes with a distinctive wedge-shaped configuration showing activation of the WNT pathway, with unusual cyto-architectural features. It is unclear whether they show a distinct genomic profile associated with a diverse metastatic potential. We describe herein a cohort of 21 atypical DPNs analyzed by next-generation sequencing using the Ion AmpliSeq™ Comprehensive Cancer Panel. We found that β-catenin exon 3 was mutated in 95% and MAP kinase pathway genes in 71% of the cases. Less frequent mutations were observed in HRAS (19%) and MAP2K1 (24%). Isocitrate dehydrogenases 1 (IDH1) mutations, including R132C, V178I, and S278L, were identified in 38% of cases and co-existed with BRAF/HRAS mutations. The only case with progressive nodal disease carried alterations in the β-catenin pathway and mutations in IDH1 and NRAS (codon 61). By a comprehensive mutation analysis, we found low genetic heterogeneity and a lack of significant associations between specific gene mutations and histopathological features, despite atypical features. Whether the acquisition of an NRAS or IDH1 mutation in an atypical DPN may represent a molecular evolution implying a pathway to melanoma progression should be confirmed in a larger series.
Review of PP2A Tumor Biology and Antitumor Effects of PP2A Inhibitor LB100 in the Nervous System
Authors: Bryant Jean-Paul , Levy Adam , Heiss John , Banasavadi-Siddegowda Yeshavanth Kumar
Published: June 2021

Protein phosphatase 2A (PP2A) is a ubiquitous serine/threonine phosphatase implicated in a wide variety of regulatory cellular functions. PP2A is abundant in the mammalian nervous system, and dysregulation of its cellular functions is associated with myriad neurodegenerative disorders. Additionally, PP2A has oncologic implications, recently garnering attention and emerging as a therapeutic target because of the antitumor effects of a potent PP2A inhibitor, LB100. LB100 abrogation of PP2A is believed to exert its inhibitory effects on tumor progression through cellular chemo- and radiosensitization to adjuvant agents. An updated and unifying review of PP2A biology and inhibition with LB100 as a therapeutic strategy for targeting cancers of the nervous system is needed, as other reviews have mainly covered broader applications of LB100. In this review, we discuss the role of PP2A in normal cells and tumor cells of the nervous system. Furthermore, we summarize current evidence regarding the therapeutic potential of LB100 for treating solid tumors of the nervous system.
The Impact of Biomass and Acid Loading on Methanolysis during Two-Step Lignin-First Processing of Birchwood
Authors: Kouris Panos D. , Huang Xiaoming , Ouyang Xianhong , van Osch Dannie J. G. P. , Cremers Geert J. W. , Boot Michael D. , Hensen Emiel J. M.
Published: June 2021

We optimized the solvolysis step in methanol for two-step lignin-first upgrading of woody biomass. Birchwood was first converted via sulfuric acid methanolysis to cellulose pulp and a lignin oil intermediate, which comprises a mixture of lignin oligomers and C5 sugars in the methanol solvent. The impact of reaction temperature (140–200 °C), acid loading (0.24–0.81 wt%, dry biomass), methanol/biomass ratio (2.3/1–15.8/1 w/w) and reaction time (2 h and 0.5 h) was investigated. At high biomass loadings (ratio < 6.3/1 w/w), operation at elevated pressure facilitates delignification by keeping methanol in the liquid phase. A high degree of delignification goes together to a large extent with C5 sugar release, mostly in the form of methyl xylosides. Gel permeation chromatography and heteronuclear single quantum coherence NMR of lignin fractions obtained at high acid (0.81 wt%) and low biomass (15.8/1 w/w) loading revealed extensive cleavage of β-O-4′ bonds during acidolysis at 180 °C for 2 h. At an optimized methanol/biomass ratio of 2.3/1 w/w and acid loading (0.24 wt%), more β-O-4′ bonds could be preserved, i.e., about 33% after 2 h and 47% after 0.5 h. The high reactivity of the extracted lignin fragments was confirmed by a second hydrogenolysis step. Reductive treatment with Pd/C under mild conditions led to disappearance of ether linkages and molecular weight reduction in the hydrotreated lignin oil.
Structure and Abundance of Fusarium Communities Inhabiting the Litter of Beech Forests in Central Europe
Authors: Stępniewska Hanna , Jankowiak Robert , Bilański Piotr , Hausner Georg
Published: June 2021

Members of the genus Fusarium and related genera are important components of many ecosystems worldwide and are responsible for many plant diseases. However, the structure of beech litter-inhabiting Fusarium communities and their potential role in reducing the natural regeneration of European beech are not well understood. To address this issue, we examined Fusarium communities in the litter of uneven-aged, old-growth beech-dominated forests in the Carpathians (Poland) and in the Alps (Austria), and in a managed beech stand (Poland). The fungi inhabiting beech litter were investigated using beechnuts and pine seedlings as bait. The pathogenicity of the most common species was investigated by inoculating beech germinants. Fusarium spp. were identified based on morphology and DNA sequence comparisons of RPB2 and TEF1-α genes, combined with phylogenetic analyses. Twelve fungal species were identified from 402 isolates, including nine known and three currently undescribed species. The isolates resided in three species complexes within the genus Fusarium. These were the F. oxysporum (one taxon), F. sambucinum (three taxa), and F. tricinctum (six taxa) species complexes. In addition, one isolate was assigned to the genus Neocosmospora, and one isolate could be placed within the genus Fusicolla. The most frequently isolated fungi from beechnuts and beech germinants were F. avenaceum (Fr.) Sacc., F. sporotrichioides Sherb. and Fusarium sp. B. The structure and abundance of species within Fusarium communities varied by beech forest type. The species richness of Fusarium spp. was greatest in old-growth beech-dominated stands, while abundances of Fusarium spp. were higher in managed beech-dominated stands. Pathogenicity tests showed that all four Fusarium species isolated from beechnuts and beech germinants could cause germinants to rot beech, suggesting that these fungi may play a negative role in the natural beech regeneration.
Socioeconomic Correlates of Anti-Science Attitudes in the US
Authors: Hu Minda , Rao Ashwin , Kejriwal Mayank , Lerman Kristina
Published: June 2021

Successful responses to societal challenges require sustained behavioral change. However, as responses to the COVID-19 pandemic in the US showed, political partisanship and mistrust of science can reduce public willingness to adopt recommended behaviors such as wearing a mask or receiving a vaccination. To better understand this phenomenon, we explored attitudes toward science using social media posts (tweets) that were linked to counties in the US through their locations. The data allowed us to study how attitudes towards science relate to the socioeconomic characteristics of communities in places from which people tweet. Our analysis revealed three types of communities with distinct behaviors: those in large metro centers, smaller urban places, and rural areas. While partisanship and race are strongly associated with the share of anti-science users across all communities, income was negatively and positively associated with anti-science attitudes in suburban and rural areas, respectively. We observed that emotions in tweets, specifically negative high arousal emotions, are expressed among suburban and rural communities by many anti-science users, but not in communities in large urban places. These trends were not apparent when pooled across all counties. In addition, we found that anti-science attitudes expressed five years earlier were significantly associated with lower COVID-19 vaccination rates. Our analysis demonstrates the feasibility of using spatially resolved social media data to monitor public attitudes on issues of social importance.
Genetic History of the Remnant Population of the Rare Orchid Cypripedium calceolus Based on Plastid and Nuclear rDNA
Authors: Górniak Marcin , Jakubska-Busse Anna , Ziętara Marek S.
Published: June 2021

The lady’s slipper orchid (Cypripedium calceolus), which inhabits shady deciduous and mixed forests and meadows, is now threatened with extinction in many European countries, and its natural populations have been dramatically declining in recent years. Knowledge of its evolutionary history, genetic variability, and processes in small populations are therefore crucial for the species’ protection. Nowadays, in south-west Poland, it is only distributed in seven small remnant and isolated populations, which we examined. One nuclear (ITS rDNA) and two plastid (accD-psa1, trnL-F) markers were analyzed and compared globally in this study. Based on the nuclear marker, the most common ancestor of C. calceolus and Cypripedium shanxiense existed about 2 million years ago (95% HPD: 5.33–0.44) in Asia. The division of the C. calceolus population into the European and Asian lineages indicated by C/T polymorphism started about 0.5 million years ago (95% HPD: 1.8–0.01). The observed variation of plastid DNA, which arose during the Pleistocene glacial–interglacial cycles, is still diffuse in Poland. Its distribution is explained by the result of fragmentation or habitat loss due to human impact on the environment.
Expression of Wnt and TGF-Beta Pathway Components during Whole-Body Regeneration from Cell Aggregates in Demosponge Halisarca dujardinii
Authors: Borisenko Ilya , Bolshakov Fyodor V. , Ereskovsky Alexander , Lavrov Andrey I.
Published: June 2021

The phenomenon of whole-body regeneration means rebuilding of the whole body of an animal from a small fragment or even a group of cells. In this process, the old axial relationships are often lost, and new ones are established. An amazing model for studying this process is sponges, some of which are able to regenerate into a definitive organism after dissociation into cells. We hypothesized that during the development of cell aggregates, primmorphs, new axes are established due to the activation of the Wnt and TGF-beta signaling pathways. Using in silico analysis, RNA-seq, and whole-mount in situ hybridization, we identified the participants in these signaling pathways and determined the spatiotemporal changes in their expression in demosponge Halisarca dujardinii. It was shown that Wnt and TGF-beta ligands are differentially expressed during primmorph development, and transcripts of several genes are localized at the poles of primmorphs, in the form of a gradient. We suppose that the Wnt and TGF-beta signaling cascades are involved in the initial axial patterning of the sponge body, which develops from cells after dissociation.
Walking Cadence during Moderate-Intensity Physical Activity in Pregnant Women
Authors: Marshall Mallory , Birchfield Beth , Rogers Rebecca , Senga Joyeuse , Persch McKenna , Currie Madison , Schmid Daphne , Ballmann Christopher
Published: June 2021

Evidence has established that a cadence of 100 steps/min is indicative of the moderate intensity threshold of 3 metabolic equivalents (METs), but this has only been described in non-pregnant individuals. As metabolic alterations are well established during pregnancy, the purpose of this study was to determine if the walking cadence equivalent to 3 METs in pregnant women is similar to non-pregnant populations. Pregnant females (n = 29; age = 30.3 ± 3.2 years, gestational age = 23.9 ± 6.6 weeks) in their second or third trimester (>12 weeks gestation) completed three stages of treadmill walking for 5 min at different standardized walking speeds: 2.5, 3.0, and 3.5 miles per hour (mph). Oxygen consumption (VO2) and heart rate (HR) were measured each minute and METs were calculated for each stage. Real-time continuous monitoring of walking cadence was evaluated by an OptoGait gait analysis system. Following the three standardized speed stages, participants completed an additional stage walking at a speed that elicited 100 steps/min; VO2 and HR were also collected. A one-sample t-test was used to compare MET values at each stage to the heuristic 3 MET cutoff, and Pearson correlation coefficient was calculated to evaluate the relationship between cadence and METs. Mean cadence increased linearly across the three stages (2.5 mph = 103.7 ± 4.5, 3.0 mph = 112.5 ± 5.3, and 3.5 mph = 120.4 ± 6.2 steps/min), as did METs (2.5 mph = 2.7 ± 1.7, 3.0 mph = 3.2 ± 0.8, and 3.5 mph = 4.3 ± 1.8 METs) regardless of trimester. The average treadmill speed at which women walked at 100 steps/min was 2.4 ± 0.4 mph which elicited an oxygen consumption of 9.5 mL•kg−1•min−1, or 2.7 ± 0.7 METs. There was no significant difference between METs at 3.0 mph and the conventional 3 MET cut point for moderate-intensity PA (p < 0.05). There was a moderate and significant relationship between METs and cadence (2nd trimester: r = 0.51; 3rd trimester: r = 0.42). Current data indicate for the first time that the traditionally used 3 MET cutoff for moderate-intensity activity is appropriate for pregnant women despite metabolic alterations associated with pregnancy. This may have important implications for exercise prescription in pregnant populations.
Effects of Functional Training on Sarcopenia in Elderly Women in the Presence or Absence of ACE Inhibitors
Authors: Mile Marianna , Balogh László , Papp Gábor , Pucsok József Márton , Szabó Krisztina , Barna Lilla , Csiki Zoltán , Lekli István
Published: June 2021

Sarcopenia, defined as loss of muscle mass and strength, develops gradually with aging or after chronic disease. Efforts are ongoing to identify the best interventions that can slow down or stop sarcopenia. Nutrition-based interventions and exercise therapy may be beneficial; however, pharmacotherapy also could play a role. The effect of ACE inhibitors on physical performance is controversial. The present study investigates the impact of functional training on sarcopenia in the presence or absence of ACEi in elderly females. A total of 35 women over 65 years of age were selected for two groups on the basis that they were taking ACEi (n = 18) or not (n = 17). All subjects conducted a training program two times a week for 6 months. We examined various factors related to sarcopenia. After completing the short physical performance battery (SPPB) test, we found a significant improvement after 6 months of functional training. SPPB values of the ACEi group were significantly lower at the beginning of the study; however, we observed no difference between the SPPB results of the two groups after the training period. We conducted further studies to measure posture and spine mobility. Our Schober and Cobra test results revealed significantly improved spine mobility (both flexor and extensor) in both groups after 6 months of training. Furthermore, the grip strength of the hands, studied by an electric dynamometer, was significantly improved in both groups at the end of the training period. Our results indicated that functional training may improve body composition and muscle strength in patients diagnosed with sarcopenia. Furthermore, ACEi may be a helpful additional therapy in older adult patients suffering from severe sarcopenia.
Description of Lifestyle, Including Social Life, Diet and Physical Activity, of People ≥90 years Living in Ikaria, a Longevity Blue Zone
Authors: Legrand Romain , Nuemi Gilles , Poulain Michel , Manckoundia Patrick
Published: June 2021

A cross-sectional observational study was conducted to describe the lifestyle of people ≥90 years, living in Evdilos or Raches, two municipalities of the Greek island of Ikaria, classified a longevity blue zone. The 71 participants were interviewed and underwent the Mediterranean Islands study food frequency questionnaire (MEDIS-FFQ) and the international physical activity questionnaire (IPAQ). The frequency of social contacts was daily for 77.9% of participants, weekly for 16.1%, and monthly for 5.9%. Most participants (90.0%) believed in God, and 81.4% took part in religious events. A total of 62.0% attended Panigiria festivals. Access to primary health care was considered difficult in the past for 66.2% of participants, while 22.1% felt that it remained difficult at the time of the survey. The level of adherence to the Mediterranean diet was 62.7% (61.6% in women and 64.0% in men). Physical activity levels were moderate or high for 71.8% of participants (59.5% of women and 85.3% of men). In conclusion, the participants had a very high level of family solidarity, social interaction and physical activity. The results concerning the Mediterranean diet are less convincing. It would be interesting to study the impact of these factors on the longevity of the oldest old aged people living in Ikaria.
COVID-19 Inequalities: Individual and Area Socioeconomic Factors (Aragón, Spain)
Authors: Aguilar-Palacio Isabel , Maldonado Lina , Malo Sara , Sánchez-Recio Raquel , Marcos-Campos Iván , Magallón-Botaya Rosa , Rabanaque Mª José
Published: June 2021

It is essential to understand the impact of social inequalities on the risk of COVID-19 infection in order to mitigate the social consequences of the pandemic. With this aim, the objective of our study was to analyze the effect of socioeconomic inequalities, both at the individual and area of residence levels, on the probability of COVID-19 confirmed infection, and its variations across three pandemic waves. We conducted a retrospective cohort study and included data from all individuals tested for COVID-19 during the three waves of the pandemic, from March to December 2020 (357,989 individuals) in Aragón (Spain). We studied the effect of inequalities on the risk of having a COVID-19 confirmed diagnosis after being tested using multilevel analyses with two levels of aggregation: individuals and basic healthcare area of residence (deprivation level and type of zone). Inequalities in the risk of COVID-19 confirmed infection were observed at both the individual and area level. There was a predominance of low-paid employees living in deprived areas. Workers with low salaries, unemployed and people on minimum integration income or who no longer receive the unemployment allowance, had a higher probability of COVID-19 infection than workers with salaries ≥ €18,000 per year. Inequalities were greater in women and in the second wave. The deprivation level of areas of residence influenced the risk of COVID-19 infection, especially in the second wave. It is necessary to develop individual and area coordinated measures by areas in the control, diagnosis and treatment of the epidemic, in order to avoid an increase in the already existing inequalities.
Future Incidence of Malignant Mesothelioma in South Korea: Updated Projection to 2038
Authors: Kwak Kyeongmin , Cho Sung-il , Paek Domyung
Published: June 2021

Malignant mesothelioma (MM) is a cancer that is largely caused by exposure to asbestos. Although asbestos is no longer used in South Korea, the incidence of MM continues to increase due to its long latent period. We aimed to update the previous prediction of MM incidence until 2038. We predicted the incidence of MM over the next 20 years (2019–2038) in South Korea using Møller’s age–period–cohort (APC) model and a Poisson regression model based on asbestos consumption. The APC model predicted that the crude incidence rate would increase sharply in men and slowly in women. Despite the sex discrepancy in the rate of increase, the incidence rate for both sexes is expected to continue increasing until 2038. In the Poisson model, the crude incidence rate was predicted to increase continuously until 2038, and far more cases of MM were predicted to occur compared with the results of the APC model. When compared with actual incidence data, the APC model was deemed more suitable than the Poisson model. The APC model predicted a continuous increase over the next 20 years with no peak, suggesting that the incidence of MM will continue to rise far into the future.
The Effectiveness of Additional Core Stability Exercises in Improving Dynamic Sitting Balance, Gait and Functional Rehabilitation for Subacute Stroke Patients (CORE-Trial): Study Protocol for a Randomized Controlled Trial
Authors: Cabanas-Valdés Rosa , Boix-Sala Lídia , Grau-Pellicer Montserrat , Guzmán-Bernal Juan Antonio , Caballero-Gómez Fernanda Maria , Urrútia Gerard
Published: June 2021

Background: Trunk impairment produces disorders of motor control, balance and gait. Core stability exercises (CSE) are a good strategy to improve local strength of trunk, balance and gait. Methods and analysis: This is a single-blind multicenter randomized controlled trial. Two parallel groups are compared, and both perform the same type of therapy. A control group (CG) (n = 110) performs conventional physiotherapy (CP) (1 h per session) focused on improving balance. An experimental group (EG) (n = 110) performs CSE (30 min) in addition to CP (30 min) (1 h/session in total). EG is divided in two subgroups, in which only half of patients (n = 55) perform CSE plus transcutaneous electrical nerve stimulation (TENS). Primary outcome measures are dynamic sitting, assessed by a Spanish version of Trunk Impairment Scale and stepping, assessed by Brunel Balance Assessment. Secondary outcomes are postural control, assessed by Postural Assessment Scale for Stroke patients; standing balance and risk of fall assessed by Berg Balance Scale; gait speed by BTS G-Walk (accelerometer); rate of falls, lower-limb spasticity by Modified Ashworth Scale; activities of daily living by Barthel Index; and quality of life by EQ-5D-5L. These are evaluated at baseline (T0), at three weeks (T1), at five weeks (end of the intervention) (T2), at 17 weeks (T3) and at 29 weeks (T4). Study duration per patient is 29 weeks (a five-week intervention, followed by a 24-week post-intervention).
The Impact of Mental Health Status on Health Consumption of the Elderly in China
Authors: Liu Wen , Han Guosheng , Yan Xiangzi , Zhang Xuan , Ning Guangjie , Akhmedov Armigon Ravshanovich , Hunter William Cannon
Published: June 2021

Based on the national baseline survey data of the CHARLS2015, the comprehensive evaluation index of depression degree of the elderly in China is calculated using a principal component analysis method. The Tobit model is used to investigate the influence of mental health status with depression degree as a proxy variable on the health consumption of the elderly in China. The results show that the overall effect and the phased effect of depression on the health consumption of the elderly are positive. In other words, high levels of depression lead to a higher probability and amount of health consumption. Research findings show that chronic illness and increased social activity can weaken the effect of depression on the health spending of the elderly. Fully considering the factors affecting the mental health of elderly people is required to improve their level of mental health. Importantly, the quality audit system of health products and the supervision and management system of the health consumption market should be improved to realize the benign operation of the health consumption market.
Lifestyle Factors and Sleep Health across the Lifespan
Authors: Dzierzewski Joseph M. , Sabet Sahar M. , Ghose Sarah M. , Perez Elliottnell , Soto Pablo , Ravyts Scott G. , Dautovich Natalie D.
Published: June 2021

Sleep health, operationalized as a multidimensional construct consisting of sleep regularity, satisfaction, alertness, timing, efficiency, and duration, is an emerging concept in the field of sleep medicine which warrants further investigation. The purpose of the present study was to: (1) compare sleep health across the lifespan, (2) determine lifestyle factors associated with sleep health, and (3) examine whether lifestyle factors associated with sleep health varied between and within age groups. Participants consisted of 3284 individuals (Mean age = 42.70; 45% male) who participated in a cross-sectional online survey of sleep and health. Sleep health was measured using the RU-SATED scale, while demographic and lifestyle factors (e.g., daily social media use, sedentary activity, fast food consumption, etc.) were all self-reported. Sleep health was the highest among older adults (M = 8.09) followed by middle-aged (M = 7.65) and younger adults (M = 7.16). Across age groups, fast-food consumption, daily regularity, and daily TV, social media, or internet use were all negatively correlated with sleep health (ps < 0.05). Few differences in the association between lifestyle factors and sleep health across age groups were found. Overall, these findings may help to inform sleep health promotion efforts by targeting the most pertinent lifestyle factors for promoting sleep health.
Associations between Black and Mild Cigar Pack Size and Demographics and Tobacco Use Behaviors among US Adults
Authors: Ganz Ollie , King Jessica L. , Giovenco Daniel P. , Hrywna Mary , Strasser Andrew A. , Delnevo Cristine D.
Published: June 2021

Pack size is an important pricing strategy for the tobacco industry, but there is limited data on how users differ based on preferred pack size for cigar products. Using data from Wave 4 of the Population Assessment of Tobacco and Health Study, this study identified differences in adult cigar user characteristics based on pack size purchasing behavior among users of a top cigar brand, Black and Mild. Weighted chi-square tests were used to examine the associations between Black and Mild pack size and sociodemographic, cigar and other substance use characteristics. Overall, our study found that users of Black and Mild cigars differ by demographic, cigar and other tobacco use characteristics based on preferred pack size, with smaller packs appealing to younger, female, less-experienced and less-established smokers, and larger packs appealing to older, male, more experienced, and more dependent cigar smokers. Dual use of cigarettes and cigars was also higher among users of smaller packs. While this study is cross-sectional, findings suggest that minimum packaging laws for cigars may impact younger adults who are purchasing smaller pack sizes and likely experimenting with new cigar products and styles.
Association with Ambient Air Pollutants and School Absence Due to Sickness in Schoolchildren: A Case-Crossover Study in a Provincial Town of Japan
Authors: Watanabe Masanari , Noma Hisashi , Kurai Jun , Kato Kazuhiro , Sano Hiroyuki
Published: June 2021

The effect of ambient air pollutants and Asian dust (AD) on absence from school due to sickness has not been well researched. By conducting a case-crossover study, this study investigated the influence of ambient air pollutants and desert sand dust particles from East Asia on absence from school due to sickness. From November 2016 to July 2018, the daily cases of absence due to sickness were recorded in five elementary schools in Matsue, Japan. During the study period, a total of 16,915 absence cases were recorded, which included 4865 fever cases and 2458 cough cases. The relative risk of overall absence in a 10-μg/m3 increment of PM2.5 and a 0.1-km−1 of desert sand dust particles from East Asia were found with 1.28 (95%CI: 1.15–1.42) and 2.15 (1.04–4.45) at lag0, respectively. The significant influence of PM2.5 persisted at lag5 and that of desert sand dust particles at lag2. NO2 had statistically significant effects at lag2, lag3, and lag4. However, there was no evidence of a positive association of Ox and SO2 with absence from school. These results suggested that PM2.5, NO2, and AD increased the risk of absence due to sickness in schoolchildren.
Muscle Recovery after a Single Bout of Functional Fitness Training
Authors: García-Fernández Pablo , Cimadevilla Eduardo , Guodemar-Pérez Jesús , Cañuelo-Márquez Ana María , Heredia-Elvar Juan Ramón , Fernández-Rodríguez Tomás , Lozano-Estevan María del Carmen , Hervás-Pérez Juan Pablo , Sánchez-Calabuig María Aránzazu , Garnacho-Castaño Manuel Vicente , Hernández Lougedo Juan , Maté-Muñoz José Luis
Published: June 2021

Background: Functional fitness training (FFT) is a new exercise modality that targets functional multi-joint actions via both muscle-strengthening exercises and aerobic training intervals. The aim of the study was to examine muscle recovery over a 20 min period after an FFT workout in trained adults. Materials and methods: Participants were 28 healthy trained subjects. In a single session, a countermovement jump (CMJ) was performed to determine several mechanical variables (jump height, maximum velocity, power) before (preFFT) and 4, 10, and 20 min after the FFT workout (postFFT). In parallel, capillary blood lactate concentrations were measured pre- and 3 min postFFT. Heart rate was also measured before and after the workout, and perceived exertion was measured postFFT. Results: Significant differences between the time points preFFT and 4 min and 10 min postFFT, respectively, were produced in jump height (p = 0.022, p = 0.034), maximum velocity (p = 0.016, p = 0.005), average power relative (p = 0.018, p = 0.049), and average power total (p = 0.025, p = 0.049). No differences were observed in any of the variables recorded preFFT and 20 min postFFT. Conclusions: While mechanical variables indicating muscle fatigue were reduced 4 and 10 min postFFT, pre-exercise jump ability only really started to recover 20 min after FFT although not reaching pre-exercise levels. This means that ideally intervals of around 20 min of rest should be implemented between training bouts.
Long-Term Outcomes of Radiofrequency Ablation for Treatment of Cystic Warthin Tumors versus Solid Warthin Tumors
Authors: Cha Chih-Hung , Luo Sheng-Dean , Chiang Pi-Ling , Chen Wei-Chih , Tung Yu-Cheng , Su Yan-Ye , Lin Wei-Che
Published: June 2021

Background: To describe the long-term outcomes of radiofrequency ablation (RFA) of parotid Warthin tumors that have different consistencies and locations. Methods: We reviewed ten patients with Warthin tumors undergoing RFA treatment from 2016 to 2019. The mean follow-up was 24.3 ± 13.1 months (range 7–42 months). Results: RFA was performed on 11 tumors in ten patients. Cystic tumors (n = 4) had better volume reduction ratios (VRR) than solid tumors (n = 7) at month one and month six, following RFA (77.9% vs. 47.3%, 95.1% vs. 80.6%, respectively, p = 0.003). Tumors in both superficial lobes and deep lobes (n = 7) were larger than tumors in superficial lobes alone (n = 4), though there was no difference in VRR after treatment. All residual tumors were found in superficial lobes. There was no increase in residual tumor size. Every patient showed marked cosmetic improvements, with visible tumors becoming non-palpable masses. Conclusions: RFA is a safe and effective treatment for Warthin tumors, with better volume reduction in cystic tumors. Results remained satisfying over the long-term for all residual tumors found in superficial lobes, making it easier for re-intervention if necessary.
Gaming among Children and Adolescents during the COVID-19 Lockdown: The Role of Parents in Time Spent on Video Games and Gaming Disorder Symptoms
Authors: Donati Maria Anna , Guido Cristiana Alessia , De Meo Giuliano , Spalice Alberto , Sanson Francesco , Beccari Carola , Primi Caterina
Published: June 2021

It is mainly children and adolescents who are involved in video gaming. The lockdown caused by the COVID-19 pandemic may have further increased their use of video games and, consequently, the risk of gaming disorder (GD) symptoms. However, currently, we do not have exhaustive knowledge of this issue. To fill this gap, the current study aims to analyze video gaming habits in children and adolescents during the lockdown, starting in March 2020 in Italy, the first European country affected by the pandemic. Specifically, we aim to understand how variables related to parents—for instance, knowledge of their offspring’s life, the monitoring of their video gaming habits, and parental use of video games—are related to their offspring’s time spent on video games and GD symptoms. A web-based survey involving parents (n = 554, 79% mothers, mean age = 45.39) of 554 children and adolescents (73% males, mean age = 11.11) was utilized. The results showed that they were involved in video games, particularly boys and adolescents, with high rates of GD symptoms. The parents also spent a considerable amount of time playing video games. A path model that explained the mechanisms through which parental variables were related to their offspring’s time spent on video games and GD symptoms, controlling for gender and age, was verified. Overall, the findings indicate the importance of educating parents to behave effectively with respect to video games and monitor their offspring’s video gaming habits.
Association between Occupational Dysfunction and Social Isolation in Japanese Older Adults: A Cross-Sectional Study
Authors: Fujii Keisuke , Fujii Yuya , Kubo Yuta , Tateoka Korin , Liu Jue , Nagata Koki , Wakayama Shuichi , Okura Tomohiro
Published: June 2021

We clarified the relationship between occupational dysfunction and social isolation among community-dwelling adults. We used a self-administered questionnaire with a cross-sectional study for 2879 independently living older adults in Kasama City, Japan. Participants responded to a self-reported questionnaire in November 2019. Occupational dysfunction and social isolation were assessed. The participants were classified into two groups: healthy occupational function group, and occupational dysfunction group. To examine the relationship between occupational dysfunction and social isolation, we performed a logistic regression analysis with social isolation as a dependent variable and occupational dysfunction as an independent variable. In the crude model, the occupational dysfunction group had a higher risk of social isolation than the healthy occupational function group (odds ratio (OR) = 2.04; 95% confidence interval (CI), 1.63–2.55; p < 0.001). In the adjusted model, the occupational dysfunction group had a higher risk of social isolation than the healthy occupational function group (OR = 1.51; 95% CI, 1.17–1.94; p = 0.001). The results showed that occupational dysfunction was significantly associated with social isolation. These results can be used in constructing a support method for social isolation from a new perspective.