bluuebunny/crossref_metadata_2025 huggingface dataset:
Desempenho térmico de jardins verticais de tipologia fachada verde
Authors: Muñoz Luiza Sobhie , Cruciol Barbosa Murilo , Fontes Maria Solange Gurgel de Castro , Faria João Roberto Gomes de
Published: March 2019

As fachadas verdes, uma das tipologias de jardins verticais, utilizam espécies de trepadeiras ou pendentes que crescem e se desenvolvem em superfícies verticais. Sua aplicação nas fachadas dos edifícios traz diversos benefícios, tais como a melhoria das condições de conforto térmico em seu interior e a diminuição dos efeitos das ilhas de calor urbanas. Essa melhoria ocorre em razão dos seguintes mecanismos de ação dos jardins verticais: (i) sombreamento; (ii) resfriamento evapotranspirativo; (iii) influência na dinâmica do vento e (iv) isolamento térmico da edificação. Nesse contexto, esse artigo apresenta o estado da arte acerca do potencial amenizador térmico das fachadas verdes, a partir da análise dos objetivos, metodologias e principais resultados de artigos de periódicos e dissertações buscados nas bases Scopus, Web of Science™, P@rthenon e a Biblioteca Digital Brasileira de Dissertações e Teses. Do material encontrado foram analisados 23 trabalhos, selecionados pelos seguintes critérios: (i) trabalhos que tratam do desempenho térmico das fachadas verdes e (ii) trabalhos experimentais e estudos de caso. Os resultados confirmam o potencial amenizador térmico das fachadas verdes e indicam lacunas de pesquisa, como a falta de trabalhos que comparem o desempenho térmico de diferentes espécies de trepadeiras e fachadas verdes diretas e indiretas, e lacunas informacionais, como a escassez de detalhes sobre as espécies selecionadas e as estruturas e materiais adotados nos estudos. Além disso, os resultados também indicam temas para possíveis futuros trabalhos sobre o desempenho térmico dessa tipologia de jardim vertical.
Residência em contêiner: comparativo de estratégias para a melhoria do desempenho térmico
Authors: Viana Françoíse Santana , Souza Henor Artur de , Gomes Adriano Pinto
Published: March 2019

A construção civil passa atualmente por desafios em construir de forma mais econômica e ambientalmente correta. Neste trabalho visa-se conhecer melhor o equipamento não convencional utilizado para edificações, o contêiner, avaliando seu desempenho térmico. O contêiner é escolhido como objeto de estudo pois é um módulo que pode ser adaptado para diversos tipos de climas, terrenos e construções. E como no Brasil sua utilização na construção é recente, torna-se necessário uma análise para entender como adaptá-lo de forma eficiente. Neste estudo, a avaliação do desempenho térmico do contêiner é feita via simulação numérica utilizando o programa Energyplus, analisando o impacto da ventilação natural e da massa térmica dos fechamentos no comportamento térmico da edificação. São consideradas as condições climáticas para as zonas bioclimáticas 2, 3 e 8, que englobam o litoral brasileiro, previstas na norma NBR 15.220-2005, observando também os requisitos mínimos da norma NBR 15.575-2013. Para o estudo, projetou-se uma casa com dois módulos de contêiner, totalizando uma área de 29,57 m². Os resultados obtidos mostram a necessidade de adaptações para que o contêiner possua habitabilidade em todas as zonas bioclimáticas analisadas. Constata-se que o uso de isolamento térmico nos fechamentos verticais, de uma cobertura termicamente eficiente, de uma fundação adequada e de cores com tons mais claros no fechamento externo proporcionam um melhor desempenho térmico à edificação, para os climas analisados.
Questionários de avaliação do conforto visual: revisão e análise
Authors: Bortolan Giovana Mara Zugliani , Ferreira Marcelo Gitirana Gomes , Tezza Rafael
Published: March 2019

O estudo da qualidade da iluminação e do conforto visual está condicionado à saúde e bem-estar daqueles que utilizam e usufruem dos espaços. A iluminação é importante na concepção de um ambiente e, dessa forma, muitos pesquisadores buscaram formas de identificar e avaliar o conforto visual por meio de diferentes instrumentos de pesquisa. Um dos mais recorrentes, o questionário, é um instrumento de coleta de dados com o intuito de avaliar as preferências e características de uma amostra. Neste contexto, o objetivo deste trabalho consistiu em identificar, detalhar e prover maior compreensão acerca dos questionários que avaliam o conforto visual, mediante uma revisão sistemática da literatura. Foram selecionados um conjunto de dezessete questionários e, assim, buscou analisa-los sob os seguintes aspectos: estrutura; objetivo da pesquisa; ambiente avaliado e principais aspectos e características da iluminação. Foi possível observar, durante a revisão sistemática, que grande parte das pesquisas encontradas, que mensuram o conforto visual, o fazem para ambientes de escritórios. Além disso, foi constatado que os aspectos preferências e satisfação; e brilho da fonte/ofuscamento e distribuição da luz são as características mais recorrentes nos questionários analisados. Este trabalho visa contribuir para o desenvolvimento de pesquisas que requerem um questionário como parte do método de avaliação.
Analysis of the prevalence of dental and occlusal anomalies in children and adolescents in Poland and elsewhere – review of the publications from the last 10 years
Authors: Cudziło Dorota , Sikorska Agnieszka , Matthews-Kozanecka Maja , Matthews-Brzozowska Teresa
Published: March 2019

Introduction. Dental and occlusal anomalies constitute a very common disorder of the mastication organ. The objective of this work was to analyse papers published over the last decade on the prevalence of the mastication irregularities in Poland and elsewhere.Material and Methods. The work analyses 22 publications, i.e. 6 papers on disorders in children and adolescents in Poland and 16 papers discussing such abnormalities elsewhere.Results. Prevalence of malocclusion in the population of children and adolescents in Poland fluctuates between 52.5% and 88%, depending on the region. As regards scientific works published abroad, malocclusion oscillates between 33% and 95.6%, depending on the country.Conclusions. Occlusal defects are diagnosed in children and adolescents both in Poland and elsewhere and the prevalence of the mastication anomalies depends neither on race nor on ethnic origin.
Healthy lifestyles in the perspective of homo eligens
Authors: Stępniak Piotr
Published: March 2019

The article is devoted to lifestyles in the context of health. According to vision of A. Siciński — lifestyle is a culturally conditioned way of meeting needs, habits and norms. They regulate the value systems adopted by an individual or group. Lifestyle is formed by the interaction of widely understood living conditions and individual patterns of behavior. Behaviors in turn are determined by personal characteristics and sociocultural factors. Lifestyle and health behaviors are shaped throughout a person's life, but its foundations are formed in childhood and adolescence. The author of the article considers that a key category in the analysis of pro or anti-healthy lifestyle is the free choice of man. A man can decide how he wants to live and also in what health he wants to live. His choices determine the way of life. The theoretical basis for discussing in this article the above-mentioned issue will be Siciński's concept of so-called homo eligens which is little known, but worthy of dissemination. It is the most important part of his theory of lifestyles.
Histological evaluation of kidney development in young rats after a surgery and management of wound with fibrin glue
Authors: Pańczyszyn Dariusz , Kroll Paweł , Jagielska Joanna , Tabaczewski Piotr , Grochowalski Marcin , Żurawski Jakub
Published: March 2019

Aim. The subject of this study is evaluation of histological hallmarks of kidney growth in rats after a surgery and subsequent management of the wound with fibrin glue. Material and Methods. Sixty-five Wistar rats underwent a surgical procedure resulting in parenchymal injury by incision followed by an application of fibrin glue. Kidneys have been examined and evaluated histologically after 4 weeks (group I) and 26 weeks (group II) after the surgery Results. When fibrin glue was used, in both groups, regular anastomoses of the wound edges of the kidney after surgery were noted. Histological features of kidney growth (renal glomeruli, renal tubules and blood vessels) were observed in the parenchyma and in the postoperative scar. In the second group kidneys grew on average by 3.5mm in the longitudinal section and by 1.89 in the cross section. In this group, the number of renal glomeruli nearly doubled. Glomeruli and tubules were also found in the postoperative scar.
Studying a Light Sensor with Light: Multiphoton Imaging in the Retina
Authors: Euler Thomas , Franke Katrin , Baden Tom
Published: March 2019

Two-photon imaging of light stimulus-evoked neuronal activity has been used to study all neuron classes in the vertebrate retina, from the photoreceptors to the retinal ganglion cells. Clearly, the ability to study retinal circuits down to the level of single synapses or zoomed out at the level of complete populations of neurons, has been a major asset in our understanding of this beautiful circuit. In this chapter, we discuss the possibilities and pitfalls of using an all-optical approach in this highly light-sensitive part of the brain.
Strategies to Improve Cancer Immune Checkpoint Inhibitors Efficacy, other than Abscopal Effect: A Systematic Review
Authors: Longo Vito , Brunetti oronzo , Azzariti Amalia , Galetta Domenico , Nardulli Patrizia , Leonetti Francesco , Silvestris Nicola
Published: March 2019

Despite the impact of immune checkpoint inhibitors on malignancies treatment is unprecedented, a lack of response to these molecules is observed in several cases. Differently from melanoma and non-small cell lung cancer, where the use of immune checkpoint inhibitors results in a high efficacy, the response rate in other tumors, such as gastrointestinal cancers, breast cancer, sarcomas, and part of genitor-urinary cancers remains low. The first strategy evaluated to improve the response rate to immune checkpoint inhibitors is the use of predictive factors for the response as PD-L1 expression, tumor mutational burden, and clinical features. In addition to the identification of the patients with a high sensibility to immune checkpoint inhibitors, another approach currently under intensive investigation is the use of therapeutics in a combinatory manner with immune checkpoint inhibitors to obtain an enhancement of efficacy through the modification of the tumor immune microenvironment. In addition to the abscopal effect induced by radiotherapy, a lot of studies are evaluating several drugs able to improve response rate to immune checkpoint inhibitors, including microbiota modifiers, drugs targeting co-inhibitors receptors, anti-angiogenic therapeutics, small molecules, and oncolytic viruses. In view of the rapid and extensive development of this research field, we conducted a systematic review of the literature identifying which of these drugs are closer to achieving validation in the clinical practice.
Perturbed Ovarian and Uterine Glucocorticoid Receptor Signaling Accompanies the Balanced Regulation of Mitochondrial Function and NFκB-Mediated Inflammation under Conditions of Hyperandrogenism and Insulin Resistance
Authors: Hu Min , Zhang Yuehui , Guo Xiaozhu , Jia Wenyan , Liu Guoqi , Zhang Jiao , Cui Peng , Li Juan , Li Wei , Wu Xiaoke , Ma Hongxia , Brännström Mats , Shao Linus R , Billig Håkan
Published: March 2019

Hyperandrogenism and insulin resistance are co-pathologies of polycystic ovary syndrome (PCOS). Recent evidence has suggested that elevated local cortisol levels are associated with ovarian and endometrial insulin resistance in hyperandrogenic PCOS patients, but the molecular mechanisms underlying these clinical findings remain unclear. We and others have used chronic treatment with human chorionic gonadotropin (hCG) and insulin to create an in vivo rodent model for the onset and development of PCOS-like phenotypes. Here, we aimed to determine whether the molecular mechanisms of glucocorticoid receptor (GR) signaling, mitochondrial function, and local inflammation in the ovary and uterus are intrinsically different in PCOS-like rats compared to controls. In both the ovary and the uterus, decreased expression of two GR protein isoforms was concurrent with increased expression of Fkbp51 but not Fkbp52 mRNA in PCOS-like rats compared to controls. However, PCOS-like rats exhibited an opposite regulation of Hsd11b1 or Hsd11b2 mRNAs in the two tissues. Further, the expression of several oxidative phosphorylation-related protein components was decreased in the PCOS-like ovary and uterus, but surprisingly the expression of many genes involved in mitochondrial function and homeostasis was increased in the same tissues and animals. Additionally, PCOS-like rats showed the increased expression of ovarian and uterine NFκB signaling proteins and Tnfaip3 mRNA. In PCOS-like rats, while similar decreased expression of Il1b, Il6, and Mmp2 mRNAs was seen in the ovary and uterus, the opposite regulation of Tnfa, Ccl2, Ccl5, and Mmp3 mRNA expression was observed in the two tissues. Both ovaries and uteri from PCOS-like animals showed increased collagen deposition compared to controls. Collectively, our observations suggest that hyperandrogenism and insulin resistance disrupt ovarian and uterine GR activation and trigger compensatory or adaptive effects for mitochondrial homeostasis, allowing tissue-level maintenance of mitochondrial function in order to limit ovarian and uterine dysfunction. Our study also suggests that hyperandrogenism and insulin resistance-induced activation of NFκB signaling resulting in aberrant regulation of inflammation-related gene expression might be tissue specific in female reproductive tissues.
Wood Processing Waste—Contamination with Microscopic Fungi and Contents of Selected Bioactive Compounds
Authors: Rogoziński Tomasz , Szwajkowska-Michałek Lidia , Mirski Radosław , Stuper-Szablewska Kinga
Published: March 2019

Wood processing work stations constitute an environment producing contaminants affecting air quality in plant production facilities. A significant role among these contaminants is played by spores and hyphae of microscopic fungi. Their presence in respirable and settled dust directly affects health of employees working in those facilities. Moreover, microscopic fungi also interact with the components of wood causing its degradation. In view of the above it was decided to test several elements affecting the quality of ambient air by analysing samples collected from all accessible locations in the plant, where wood waste is accumulated. The samples were tested in terms of their concentrations of ergosterol, total phenolics, antioxidant activity as well as contents of endogenous wood sterols such as desmosterol, cholesterol, lanosterol, stigmasterol and beta-sitosterol. Analyses showed that wood waste, despite the varied location and exposure time, is material promoting growth of microscopic fungi. Several significant correlations between the analysed parameters need to be stressed, which made it possible to design the sterol bioconverison mechanism for wood, taking place as a result of growth of microscopic fungi on the wood material.
ANALISIS LENDUTAN MODEL SISTEM CAKAR AYAM MODIFIKASI DENGAN PEMBEBANAN TUNGGAL (BEBAN TITIK)
Authors: Yudandi Lutfi Ahmad , Setiawan Bambang , Djarwanti Noegroho
Published: March 2019

Soft soil has low bearing capacity and high compressibility that can cause instability and long-term degradation that can make around some road settlement or wavy. A solution to prevent this soft soil problem was built Modified Chicken Foot, The function of Chicken Foot Foundation is to increase its bearing capacity. This research is using single load with variation distance of triangle foot foundation pattern whereas analysis of deflection using finite element method based. The research shows displacement result is depend on distance between load position and foot foundation, the closer distance between foot foundation the less it would result. The displacement result that happened at roadside is larger than at middle of the road, the difference between them is -6,8% up to 67% and The displacement result that happened in plate without pipe is larger than a plate with pipe, the difference between them is 12,31% up to 59,41%.  
Estimation of Supply Chain Network Disruption of Companies Across the Country Affected by the Nankai Trough Earthquake Tsunami in Kochi City
Authors: Ogawa Yoshiki , Akiyama Yuki , Yokomatsu Muneta , Sekimoto Yoshihide , Shibasaki Ryosuke ,   Institute of Industrial Science, The University of Tokyo 4-6-1 Komaba, Meguro-ku, Tokyo 153-8505, Japan,   Center for Spatial Information Science, The University of Tokyo, Chiba, Japan,   Disaster Prevention Research Institute, Kyoto University, Kyoto, Japan,   Risk and Resilience Program, International Institute for Applied Systems Analysis (IIASA), Laxenburg, Austria
Published: March 2019

Using various types of big data on the Nankai Trough earthquake and tsunami that struck Kochi, we describe a method of simulating how economic damage to inter-enterprise transactions propagates through the supply chain and how subsequent recovery occurs. First, we enter the human losses and material damage caused by the earthquake and tsunami to estimate the material damage and labor capital loss of each enterprise based on the position information of employees. Next, we simulate the damage repercussions regarding production capacity over the entire supply chain through many tiers, and extract bottlenecks of company risk within the supply chain. It was found that bottleneck companies tend have a slow recovery rate as compared to other affected companies. They also had a tendency of being in the construction, manufacturing, wholesale, and service industry sectors, and small in scale.
Casuística de Diagnósticos do Laboratório de Patologia Veterinária no ano de 2013
Authors: Mendes Ricardo Evandro , Rhoden Leandro Anderson , Casagrande Renata Assis , Lorenzett Marina Paula , Schwertz Claiton Ismael , Henker Luan Cleber , Lucca Neuber José
Published: March 2019

Este trabalho apresenta a casuística de diagnósticos no ano de 2013 do Laboratório de Patologia Veterinária do IFC Campus Concórdia. Foram 66 diagnósticos em bovinos, 15 em ovinos e 51 em suínos, totalizando 132. Destes, 109 (82,6%) foram através de necropsias e 23 (17,4%) através de amostras formolizadas enviadas por veterinários. Em bovinos as doenças mais incidentes foram miosite clostridial, raquitismo e intoxicação por nitrato/nitrito com 3 casos cada uma (4,5%). Já em ovinos foi hemoncose com 5 casos (33,3%) e em suínos doença de Glässer com 8 casos (15,7%); meningite supurativa com 7 casos (13,7%) e circovirose com 3 casos (5,9%).
DOENÇAS DIAGNOSTICADAS PELO LABORATÓRIO DE PATOLOGIA VETERINÁRIA NO QUINQUÊNIO 2013-2017
Authors: Carneiro Christofe , Schwertz Claiton I. , Henker Luan C. , Rhoden Leandro A. , Piva Manoela M. , Gabriel Mateus E. , Lucca Neuber J. , Baldi Kelen R. A. , Casagrande Renata A. , Gomes Teane M. A. , Mendes Ricardo E.
Published: March 2019

Este trabalho apresenta a casuística de diagnósticos nos anos de 2013 a 2017 do Laboratório de Patologia Veterinária do IFC Campus Concórdia. Foram 865 diagnósticos em bovinos, 131 em ovinos e 367 em suínos, totalizando 1363. Destes, 1000 (80,4%) foram através de necropsias e 363 (19,6%) através de amostras formolizadas enviadas por veterinários. Em bovinos as doenças mais incidentes foram miosite clostridial com 34 casos (3,8%); babesiose com 31 casos cada (3,6%); leucose enzoótica bovina com 28 casos (3,2%); anaplasmose com 27 casos (3,1%); hemoncose com 26 casos (3,0%); intoxicação por Pteridium arachnoideumcom 26 casos (3,0%); peritonite com 23 casos (2,7%) e endocardite com 23 casos (2,7%). Já em ovinos hemoncose com 28 casos (21,4%) e suínos doença de Glässer com 27 casos (7,3%) e circovirose com 22 casos (6,0%).
Assessment of HCV viral load, genotype, liver biomarkers and clinical symptoms: Developing a mathematical model for prediction of HCV load
Authors: Basharkhah Samira , Sabet Faezeh , Jahantightigh Hamid Reza , Ghezeldasht Sanaz Ahmadi , Mosavat Arman , Barati Elham , Shamsian Khosrow , Moghaddam Masoud Saleh , Sharebyani Hiva , Hassannia Tahereh , Shamsian Seyed Ali Akbar
Published: March 2019

Background

Hepatitis C virus infection is a major worldwide public health problem with about 1.75 million new HCV cases and 71 million HCV chronic infections around the world. The aim of study was to evaluate clinical, serological, molecular, and liver markers to develop a mathematical predictive model for HCV viral load quantification in chronic HCV infected patients.

Methods

In this cross-sectional study, blood samples were taken from 249 recently diagnosed HCV-infected subjects and were tested for liver condition, viral genotype, and HCV RNA load. Receiver operating characteristics (ROC) curves and multiple linear regression analysis were used to predict HCV viral load.

Results

The genotype 3 followed by genotype 1 were the most prevalent genotypes in Mashhad, Northeastern Iran. HCV viremia was significantly associated with genotyping (p=0.04). The maximum levels of viral load were detected in the mixed genotype group, and the lowest levels in the undetectable genotype group. Log of HCV viral load was significantly associated with thrombocytopenia and higher serum levels of alanine transaminase (ALT). In addition, log HCV RNA was significantly higher in patients with arthralgia, fatigue, fever, vomiting or dizziness. Moreover, genotype 3 was significantly associated with icterus. A ROC curve analysis revealed that the best cut-off points for serum levels of aspartate aminotransferase (AST), ALT, and alkaline phosphatase (ALP) were >31, >34, and ≤246 IU/L, respectively. Sensitivity, specificity and positive predictive values for AST were 87.7%, 84.36% and 44.6%, for ALT; 83.51%, 81.11% and 36%, and for ALP were 72.06%, 42.81% and 8.3%, respectively.

Conclusions

A mathematical regression model was developed that can estimate the HCV viral load. Regression model: log viral load=7.69-1.01×G3-0.7×G1+0.002×ALT-0.86× fatigue.
Blinatumomab in the Treatment of Acute Lymphoblastic Leukemia: Russian Multicenter Clinical Trial
Authors: Bondarenko Sergei Nikolaevich , Parovichnikova E.N. , Maschan A.A. , Baranova O.Yu. , Shelekhovas T.V. , Doronin V.A. , Mel'nichenko V.Ya. , Kaplanov K.D. , Uspenskaya O.S. , Sokolov A.N. , Myakova N.V. , Moiseev I.S. , Markova I.V. , Darskaya E.I. , Smirnova A.G. , Bykova T.A. , Ayubova B.I. , Samorodova I.A. , Babenko E.V. , Barkhatov I.M. , Gindina T.L. , Kulagin A.D. , Afanas'ev B.V.
Published: March 2019

Background. Recent advances in the treatment of relapsed/refractory acute lymphoblastic leukemia (R/R ALL) are attributed to the implementation of immunotherapy methods which include blinatumomab, the bispecific engager of a patient's endogenous T-cells (Blincyto™, Amgen®) (BC). Aim. To assess BC efficacy and toxicity in the treatment of R/R ALL patients with persistence of minimal tumor clone before and after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Materials & Methods. The trial included 66 B-ALL patients with CD19+ aged 18 to 72 years, 23 (35 %) of them with measurable minimal residual disease (MRD+) and 43 (65 %) with R/R ALL. In 18 (27 %) patients BC was administered after prior allo-HSCT. Results. In the overall group 2-year overall survival (OS) and disease-free survival (DFS) in patients with response to BC treatment were 53 % and 38 % respectively. In the R/R ALL group complete remission (CR) was achieved in 29 (67 %) patients including 24 (83 %) patients with negative MRD. CR rate was higher in standard cytogenetic risk group (73 %) in comparison with high-risk group (59 %). In patients with more or less than 50 % blast cells in bone marrow CR rate was 85 % and 61 %, respectively. When BC was administered after prior allo-HSCT and without it CR rate was 80 % and 60 %, respectively. In R/R ALL patients with response to BC 2-year OS and DFS were 40 % and 26 %, respectively, in the MRD+ group of ALL patients they were 66 % and 51 %, respectively. Relapse rate was lower in the group with allo-HSCT than in the group without it, i.e. 21 % vs. 55 %. Adverse events of grade 3-4 were observed in 25 (38 %) patients. In 11 (16 %) patients BC therapy had to be discontinued, in 5 (7 %) patients it was terminated prior to the scheduled date. Conclusion. BC efficacy is higher in the MRD+ group and in R/R ALL patients with smaller tumor mass. BC treatment after allo-HSCT yields remissions in most patients and can be combined with immune-adoptive therapy.
Analysis Results of the Regional Registry of Patients with Diffuse Large B-cell Lymphoma: Risk Factors and Chemo-Immunotherapy Issues
Authors: Kaplanov Kamil' Daniyalovich , Volkov N.P. , Klitochenko T.Yu. , Matveeva I.V. , Shipaeva A.L. , Shirokova M.N. , Davydova N.V. , Gemdzhian E.G. , Abramov D.S. , Konovalov D.M. , Snigur G.L. , Red'kina N.A.
Published: March 2019

Background & Aims. At least one third of patients with diffuse large B-cell lymphoma (DLBCL) are resistant to first-line therapy. R-CHOP chemo-immunotherapy does not yield acceptable results in high-risk patients. Effectiveness of options based either on increasing the dose intensity or on including auto-HSCT into the first-line therapy was not supported by the results of controlled studies. With this background the present study focuses on options, issues and failures of first-line on the basis of long-term follow-up of DLBCL patient population in the Volgograd Region. Materials & Methods. From 2004 to 2017 the population-based registry of the Hematology Department in the Volgograd Regional Clinical Oncology Dispensary included all 492 primary DLBCL patients: 235 (48 %) men and 257 (52 %) women aged 18 to 88 years. Mean and median age was 59 and 61 years, respectively. CHOP therapy was administered to 206 (42 %) patients, and 223 (45 %) patients received R-CHOP. Other regimens including NHL-BFM-90 and R-DA-EPOCH were used only in 63 (13 %) patients. Second- and third-line therapies were administered to 145 (30 %) and 54 (11 %) patients, respectively. Value of the International Prognostic Index (IPI) and immunomorphologic characteristics was determined by multivariate Cox regression analysis. Pharmacoeconomic aspect of first-line therapy failures was analyzed using Markov model. Results. Improvement of DLBCL therapy effects with the use of R-CHOP chemo-immunotherapy is particularly obvious in the groups with favorable and intermediate prognosis with 5-year overall survival (OS) of 90 % and 69 %, respectively. R-CHOP results are not considered to be satisfactory in the high-risk group: 5-year OS was 38 %. Pharmacoeconomic analysis proves the advantage of chemo-immunotherapy strategy in comparison with the period before rituximab era in terms of the life years gained (LYG) and the incremental cost-effectiveness ratio (ICER). With respect to immunotherapy effects the most significant immunomorphologic parameter is bcl-2 tumor cell expression. In the group of patients with bcl-2 > 50 % 5-year OS was 61 % with median of 88 months, event-free survival (EFS) was 52 % with median of 62 months. In the group without bcl-2 expression above the threshold 5-year OS and EFS were 88 % and 75 %, respectively, medians were not achieved. With c-myc and bcl-2 coexpression EFS and OS appeared to be even worse: 5-year EFS was 29 % with median of 6 months, and 5-year OS was 31 % with median of 15 months. Conclusion. The analysis of actual practice demonstrates the need for new options of first-line therapy for DLBCL high-risk patients and also for introducing new discriminating prognostic factors which include the IPI-independent ones.
Prognostic Value of PRAME Activity in Tumor Cells of Follicular Lymphoma
Authors: Misyurin Vsevolod Andreevich , Misyurina A.E. , Kravchenko S.K. , Lyzhko N.A. , Finashutina Yu.P. , Kasatkina N.N. , Mar'in D.S. , Nesterova E.S. , Sharkunov N.N. , Baryshnikova M.A. , Misyurin Vsevolod Andreevich
Published: March 2019

Aim. To set survival parameters for follicular lymphoma (FL) patients with different PRAME expression levels in tumor cells. Materials & Methods. The study was conducted on samples of lymph nodes, blood, and bone marrow of 34 patients with newly diagnosed FL. PRAME expression levels were measured in tumor cells (centrocytes and centroblasts) by quantitative real-time PCR. The impact of different PRAME expression levels on survival parameters was studied with median follow-up of 29 months. Clinical and laboratory characteristics used for FLIPI-1 and FLIPI-2 calculations in different patient groups were compared. Results. A high (> 5 % against ABL control gene) PRAME expression level correlates with higher Ki-67 activity (p = 0.043) and larger tumor mass (p = 0.04). Survival parameters were worse with high PRAME expression level in FL cells. Combination of both high FLIPI-1/FLIPI-2 risk and high PRAME expression level determines extremely unfavorable prognosis and may result in death. Conclusion. In FL patients high PRAME expression level in tumor cells has negative prognostic value, but only in the presence of parameters determining high FLIPI-1 and FLIPI-2 risk. Juxtaposition of PRAME expression level and FLIPI-1/ FLIPI-2 values enables most reliable prediction of early mortality in FL patients.
Treatment of Chronic Myeloid Leukemia According to Current Guidelines: The Results of the Pilot Prospective Study “Early Induction Therapy and Monitoring”
Authors: Shukhov Oleg Aleksandrovich , Turkina A.G. , Chelysheva E.Yu. , Bykova A.V. , Petrova A.N. , Gusarova G.A. , Nemchenko I.S. , Abdullaev A.O. , Obukhova T.N. , Sudarikov A.B.
Published: March 2019

Background. Current clinical guidelines on diagnosis and treatment of chronic myeloid leukemia (CML) define indications for substitution of first-line tyrosine kinase inhibitor (TKI) at therapy failure during different phases of disease progression. Aim. To assess the efficacy of CML treatment with implementing the protocol of timely monitoring and switching to another TKI. Materials & Methods. Patients were included into pilot prospective study РИТМ during 5 years. Data on 100 CML patients were analyzed. Therapy and monitoring were conducted according to the Federal clinical guidelines on CML diagnosis and therapy, 2013. Results. Median follow-up after initiation of treatment was 46 months (range 12-74). Imatinib mesylate was administered as first-line therapy to 91 (91 %) patients, 9 (9 %) patients received 2nd generation TKI (TKI2). Therapy failure was registered in 31 (31 %) patients; 26 (84 %) of them were switched to TKI2. At the time of analysis 95 (95 %) patients were followed-up. Cumulative incidence of CML-associated mortality was 2 %. By the fifth year of follow-up cumulative probability of complete cytogenetic, major and deep molecular responses was 93 %, 88 % and 66 %, respectively. Conclusion. CML treatment according to current guidelines yields the results comparable with those achieved by first-line TKI2 therapy. This approach reduces CML treatment costs and lowers the risk of TKI2-associated adverse events. Due to a high rate of deep molecular response the proportion of CML patients in remission without treatment can be increased in the future.
Soil Aggregation and Aggregate‐Associated Organic C and Total N as Affected by Revegetation Pattern at a Surface Mine on the Loess Plateau, China
Authors: Zhang Pingping , Zhang Yanle , Jia Junchao , Cui Yongxing , Wang Xia , Zhang Yanjiang , Zhang Xingchang , Wang Yunqiang
Published: March 2019

Core Ideas

Vegetation restoration improves the soil structure and enhances the OC and TN associated with soil aggregates.

A greater proportion of microaggregates with higher OC and TN were the main mechanisms for OC and TN accumulation.

Planting grasses should be a good option for the reclamation of surface mine areas.

Re‐establishing cover of vegetation can improve soil structure and increase organic carbon (OC) and total nitrogen (TN) accumulation in mine sites. In this study, we collected soil samples from reclaimed mine sites (RMSs), which comprised sites revegetated with trees (Tr), bushes (Bu), or grasses (Gr), and from the adjacent undisturbed native sites (UNSs). We evaluated the effects of revegetation patterns on: (i) soil aggregate formation and (ii) the distributions of OC and TN in different aggregate size classes. In the 0‐ to 15‐cm layer, the distribution of the aggregate sizes as well as the OC and TN concentrations in both the bulk soil and aggregate fractions did not differ significantly between the RMSs and UNSs. However, in the 15‐ to 30‐cm layer, the macroaggregate (>0.25 mm) fractions were generally lower and the microaggregate (0.25–0.053 mm) fractions were generally higher in the RMSs than the UNSs. The OC and TN concentrations in both the bulk soil and aggregate fractions were lower in the RMSs than the UNSs. Among the RMS revegetation patterns, Gr had a significantly higher proportion of microaggregates and a significantly lower proportion of the <0.053‐mm size classes than Tr in both layers. The OC and TN concentrations in both the bulk soil and aggregate fractions were significantly higher in Gr than Tr. There were no significant differences between Bu and Gr in terms of either the aggregate size distribution or the OC and TN concentrations. However, planting grasses may be a better choice considering the economic cost.
Effects of Stockpiling and Organic Matter Addition on Nutrient Bioavailability in Reclamation Soils
Authors: Gupta Sanatan Das , Kirby William , Pinno Bradley D.
Published: March 2019

Core Ideas

Stockpiling and organic matter admixing effects on reclamation soils were tested.

Stockpiling effects were stronger on forest floor based reclamation soils.

Organic matter admixing showed fertility and microbial benefits mostly in mineral sub‐soils.

A faster microbial assimilation was achieved in soils admixed with forest floor organic matter.

Nutrient bioavailability is crucial for vegetation establishment and organic matter cycling after major ecosystem disturbance such as open pit mining. In this study, the stockpiling and organic matter admixing effects on nutrient bioavailability were examined in soils used for reclaiming oil sands disturbed sites in northern Alberta, Canada. Stockpiled and directly salvaged peat mineral soil mix (PMM) and forest floor mineral soil mix (FFMM), the two main oil sands reclamation soils, and a nutrient poor mineral sub‐soil (SS) were used in this experiment. Reclamation soils were inter‐mixed at different ratios (PMM to FFMM or SS at 60:40, 80:20 and 90:10) to examine the organic matter admixing effects. Significant stockpiling effects on nutrient bioavailability and microbial functions were mostly observed in FFMM. Microbial biomass C was greater, and mineralization of lignin substrate was lower in both stockpiled PMM and FFMM soils compared to the directly salvaged soils. Significant fertility benefit was found in the FFMM‐admixed SS and PMM soils through an increase in N and K availability. FFMM admixing also increased microbial functional diversity and assimilation rate compared to the non‐admixed soils. Mineralization of polymeric substrates was the main driver of nutrient availability in stockpiled PMM, whereas carboxylic acids and carbohydrates were the major drivers in directly salvaged PMM, as indicated by the Random Forest models. The findings suggest that stockpiling effects are much stronger in FFMM than in PMM, and FFMM admixing to reclamation soils may provide nutritional and microbial functional benefits, especially in nutrient‐poor soils.
ARTICULAÇÃO ENTRE RESOLUÇÃO DE PROBLEMAS E A TEMÁTICA DROGAS COMO PROPOSTA METODOLÓGICA PARA O ENSINO DE QUÍMICA
Authors: Alves da Silva Édila Rosane , Jappe Goi Mara Elisângela
Published: March 2019

Este trabalho apresenta os resultados de uma pesquisa desenvolvida com alunos do 3° Ano do Ensino Médio de uma escola pública de ensino do município de Caçapava do Sul - RS. Essa pesquisa objetiva identificar a Resolução de Problemas como metodologia no processo ensino e aprendizagem através do uso de temáticas com alunos da Educação Básica. Para isso utilizou-se o subtema: “Drogas, o que elas têm a oferecer? ” Os referenciais teóricos adotados neste trabalho apontam o contexto metodológico e epistemológico da Resolução de Problemas e o objetivo de sua utilização no Ensino de Ciências. Para obtenção dos dados utilizou-se a pesquisa qualitativa e a análise dos resultados foram tratadas de acordo com a metodologia da Análise de Conteúdo. Como instrumento para coleta de dados aplicou-se um bloco de problemas e gravação de áudio e vídeo, para transcrição das falas dos estudantes. A partir desta pesquisa, evidenciou-se as dificuldades dos estudantes quanto aos aspectos relacionados as diferentes etapas de implementação da proposta e revelou as potencialidades do uso da Resolução de Problemas proposta a partir da temática, tais como o desenvolvimento de habilidades cognitivas para elaboração de estratégias, motivação, reflexão crítica, exposição de argumentação, entre outras desenvolvidas pelos alunos.
INSTRUMENTOS PARA INDICAÇÃO, AVALIAÇÃO E INSTITUIÇÃO DE TECNOLOGIA ASSISTIVA: REVISÃO SISTEMÁTICA
Authors: Presumido Braccialli Lígia Maria , Braccialli Ana Carla , Araújo Rita de Cássia Tibério
Published: March 2019

A taxa de abandono de tecnologia assistiva é alta, assim torna-se importante o uso de instrumento padronizados para direcionar a indicação, avaliação e implementação. Este estudo teve como objetivo identifcar e discutir os instrumentos disponiveis para a indicação, avaliaçao e implementação de tecnologia assistiva. A pesquisa configurou-se como uma revisão sistemática realizada entre 2003 e 2017, nas bases de dados: ERIC, PUBMED e PROQUEST e utilizados os descritores “assitive device” and “outcome assessment”; “assitive device” and “measurement scale”; “assistive technology” and “outcome assessment”; “assistive technology” and “measurement scale”. A busca resultou em 284 aritgos, em seguida dois pesquisadores realizaram a leitura e análise dos resumos e títulos. Foram excluídas as revisões, artigos de discussões teóricas e ponto de vista e aqueles que não correspondiam a temática, sobraram 80 artigos. As informações foram categorizadas quanto: tipo de instrumento utilizado, disponibilização do instrumento em língua portuguesa. Os resultados indicaram a utilização de 28 instrumentos específicos para avaliar predisposição, satisfação, indicação e avaliação de tecnologia assistiva, porém apenas os instrumentos Quebec user evaluation of satisfaction with assistive technology e Assistive technology device predisposition assessment estão disponiveis na lingua portuguesa. Apesar de existir diferentes instrumentos poucos estão disponíveis na língua portuguesa.
FORMAÇÃO DOCENTE PARA O TRABALHO EM SAÚDE: O "NOTÓRIO SABER" E OUTRAS PROPOSTAS DE PRECARIZAÇÂO E FLEXIBILIZAÇÃO
Authors: Bomfim Maria Inês , Morgana Goulart Valeria
Published: March 2019

Na atual conjuntura política brasileira, caracterizada por forte ajuste fiscal, cortes orçamentários, reforma trabalhista e processos restritivos à manutenção plena de direitos conquistados tardiamente pela sociedade vinculam-se à redução da participação do Estado na área social e à precarização de políticas para áreas prioritárias, como a formação de trabalhadores e de seus professores. Neste estudo, problematizamos, em especial, as tentativas de flexibilização dos requisitos ao trabalho docente, bem como o esvaziamento da política de formação de professores que, enaltecendo o saber profissional construído na prática, secundarizam aspectos da formação que não estão presentes na vida cotidiana dos profissionais da área de saúde. Com apoio em Heller (1989) e outros, defendemos que a vida cotidiana, embora importante, não é a única esfera da vida social. Concluímos que as esferas não-cotidianas mais complexas, tal como as ciências, a filosofia, a política, por exemplo, resultado da experiência acumulada pela humanidade, podem ser decisivas no processo formativo de professores para produzir o questionamento sobre o pensar, o sentir e o agir em saúde, evitando-se que a vida cotidiana se hipertrofie em relação às outras esferas, perdendo-se o poder da reflexão e da crítica sobre a realidade em que se atua.
Preparation and performance of ultra-thin surface coated pervaporation membranes for seawater purification
Authors: Nigiz F. U.
Published: March 2019

In this study, ultra-thin poly(ether-block-amide, PEBA)-coated poly(vinyl alcohol, PVA) composite membranes were prepared and assessed for the removal of lead, zinc, lithium, arsenic, and copper from seawater. Effects of the coating numbers and temperature on flux and ion rejection were evaluated. The number of coating processes increased the thicknesses of the membranes. The ion rejection and water flux decreased with the increasing coating process. Dissolved ions were retained with a rejection of >99.5%. The highest rejections of 99.99% and 99.98% were obtained for sodium and magnesium ions. The coated PVA membranes showed a superior heavy-metal removal greater than 88%. The highest rejection improvements were obtained for zinc (Zn), lithium (Li), and copper (Cu) metals. The zinc, copper, and lithium rejections increased from 89.1%, 88.3%, and 85.1% to 95.3%, 98.46% and 94.4% due to the PEBA coating process, respectively. The influence of PVA thickness on the flux and rejection was also investigated. Increasing the thickness of PVA decreased the flux. The highest flux of 2.34 kg/m2.h was obtained with the membrane having a thickness of 90 µm.
Study on the Effect of Particle Size on Viscoelastic Properties of Magnetorheological Elastomers
Authors: Gan Ruyi , Li Yaping , Qi Song , Zhu Mi , Yu Miao
Published: March 2019

Background:

As an intelligent material, Magnetorheological Elastomer (MRE) has attracted
extensive attention due to their excellent magnetic-induced properties.

Aim:

In addition to the matrix and interface, magnetic particle is the most critical factor in the magnetic
properties of MRE. Particle size does not only affect on the magnetic properties of MRE, but
also affects on interface and particle distribution. Therefore, studying the influence of particle size on
viscoelastic properties is of great significance for the MRE.

Methods:

In this paper, several kinds of MREs containing Carbonyl Iron Particles (CIPs) with different
sizes were prepared and characterized. The influences of frequency, strain and magnetic field on
viscoelastic properties of these MRE samples have been discussed comprehensively.

Results:

The result shows that the particle size has a great impact on the performance of MRE, which
indicates that the MRE performance can be improved by optimizing the particle size selection. In addition,
possible physical mechanisms have been proposed to explain the effect of particles on MRE
performance.

Conclusion:

This work can provide guidance for the performance improvement of MREs.
Use of Antifungal Creams in the Combined Treatment of Obliterating Diseases of Lower Extremities Arteries
Authors: Vasyliuk Yaroslav , Vasyliuk Sergiy
Published: March 2019

To perform clinical analysis of the effectiveness of the complex treatment of occlusive vascular diseases and fungal lesions of feet with addition of local antifungal medicines.

Materials and Methods. The results of examination and treatment of five patients with obliterating diseases of the lower limb vessels and diabetes mellitus with dermatomycosis and onychomycosis of the feet were analyzed. Onychomycosis or mycosis of feet were treated with the help of the combination of the following antifungal creams was used in the treatment: miconazole, clotrimazole, tioconazole in a ratio of 1:1:6.5 contained in the combined preparation cream “XaTonic”.

Results and discussion. The use of an antifungal mixture of creams after 7 days has led to the disappearance of the clinical manifestations of dermatomycosis of the feet in three patients, and in two patients with onychomycosis after 14 days there was the reduction of clinical symptoms.

Conclusions. The combination of three local antifungal components: miconazole, clotrimazole, thioconazole is effective in treatment of dermatomycosis of the feet. In the treatment of fungal lesions of the feet by dermatologists in patients aged after fifty years, an angiologist/vascular surgeon’s consultation is required.
Psychological Adaptation of Patients with Ischemic Heart Disease at the Stages of Rehabilitation after Reperfusion Interventions
Authors: Nesterak Roksolana
Published: March 2019

Psychological adaptation is a necessary component of rehabilitation of patients with ischemic heart disease. Post-infarction period is a special adaptation period for the patient, which requires a holistic approach taking into account both medical, physical and psychological components. High levels of anxiety in patients, both before surgical interventions, and in the postoperative period, worsen the prognosis that requires to improve the methods of rehabilitation.

         The objective of the research was to study the peculiarities of psychological adaptation in patients with ischemic heart disease, depending on reperfusion approaches and applied methods of rehabilitation.

         Materials and methods. There were examined 450 patients with ischemic heart disease using different methods of reperfusion interventions. Depending on the methods of rehabilitation, the patients were divided into three subgroups. The determination of levels of reactive and personal anxiety was performed at the beginning of treatment, 1 week, 1 month and 6 months after treatment.

         Results. There were revealed high levels of reactive and personal anxiety in patients with ischemic heart disease, which differed depending on the applied reperfusion interventions. The use of psychological methods at the stage of rehabilitation contributed to a decrease in anxiety levels a week after using suggestive therapy methods, and the effect of learning was noted a month and 6 months after the observation.

         Conclusions. One of the constituents of a cardiologic patient is his psychological status, namely the level of anxiety. For the effective adaptation, it is important to use the suggestive methods of therapy and training of patients. In patients, who are scheduled for surgical operation due to ischemic heart disease, a pre-rehabilitation with an individual approach is necessary.
AN ALGORITHM FOR THE RESTORATION OF PIXELS IMAGE BASED ON THE NEURAL NETWORK
Authors: Panishchev V. S.
Published: March 2019

In work the algorithm of restoration of the images damaged as a result of influence of noise of various nature is considered. The advantages and disadvantages of the existing approaches, as well as the prospects of using artificial neural networks, are noted. A double-layer neural network is used as an image restoration tool, and it is assumed that the location of the damaged pixels is known. A neuron is represented as a 3x3 array, where each element of the array has a pixel color value that corresponds to the value of that color in the palette. The neural network is trained on intact images, while the color difference of pixels acts as a learning criterion. For a more accurate restoration, it is ecommended at the training stage to select images similar in color to damaged ones. At the recovery stage, neurons (3x3) are formed around the damaged pixels, so that the damaged pixel is located in the middle of the neuron data array. The damaged pixel is assigned a neuron value depending on the average value of the weights matrix. An algorithm for the restoration of pixels, as well as its software implementation. The simulation was carried out in the RGB palette separately for each channel. To assess the quality of the recovery were selected groups of images with varying degrees of damage. Unlike existing solutions, the algorithm has the simplicity of implementation. The research results show that regardless of the degree of damage (within 50%), about 70% of damaged pixels are restored. Further studies suggest a modification of the algorithm to restore images with enlarged areas of damage, as well as adapting it to restore three-dimensional images.