bluuebunny/crossref_metadata_2025 huggingface dataset:
Dendrimer-Conjugated nSMase2 Inhibitor Reduces Tau Propagation in Mice
Authors: Tallon Carolyn , Bell Benjamin J. , Sharma Anjali , Pal Arindom , Malvankar Medhinee M. , Thomas Ajit G. , Yoo Seung-Wan , Hollinger Kristen R. , Coleman Kaleem , Wilkinson Elizabeth L. , Kannan Sujatha , Haughey Norman J. , Kannan Rangaramanujam M. , Rais Rana , Slusher Barbara S.
Published: September 2022

Alzheimer’s disease (AD) is characterized by the progressive accumulation of amyloid-β and hyperphosphorylated tau (pTau), which can spread throughout the brain via extracellular vesicles (EVs). Membrane ceramide enrichment regulated by the enzyme neutral sphingomyelinase 2 (nSMase2) is a critical component of at least one EV biogenesis pathway. Our group recently identified 2,6-Dimethoxy-4-(5-Phenyl-4-Thiophen-2-yl-1H-Imidazol-2-yl)-Phenol (DPTIP), the most potent (30 nM) and selective inhibitor of nSMase2 reported to date. However, DPTIP exhibits poor oral pharmacokinetics (PK), modest brain penetration, and rapid clearance, limiting its clinical translation. To enhance its PK properties, we conjugated DPTIP to a hydroxyl-PAMAM dendrimer delivery system, creating dendrimer-DPTIP (D-DPTIP). In an acute brain injury model, orally administered D-DPTIP significantly reduced the intra-striatal IL-1β-induced increase in plasma EVs up to 72 h post-dose, while oral DPTIP had a limited effect. In a mouse tau propagation model, where a mutant hTau (P301L/S320F) containing adeno-associated virus was unilaterally seeded into the hippocampus, oral D-DPTIP (dosed 3× weekly) significantly inhibited brain nSMase2 activity and blocked the spread of pTau to the contralateral hippocampus. These data demonstrate that dendrimer conjugation of DPTIP improves its PK properties, resulting in significant inhibition of EV propagation of pTau in mice. Dendrimer-based delivery of DPTIP has the potential to be an exciting new therapeutic for AD.
Transcriptomics Using the Enriched Arabidopsis Shoot Apex Reveals Developmental Priming Genes Involved in Plastic Plant Growth under Salt Stress Conditions
Authors: Cha Ok-Kyoung , Yang Soeun , Lee Horim
Published: September 2022

In the shoot apical meristem (SAM), the homeostasis of the stem cell population supplying new cells for organ formation is likely a key mechanism of multicellular plant growth and development. As plants are sessile organisms and constantly encounter environmental abiotic stresses, postembryonic development from the shoot stem cell population must be considered with surrounding abiotic stresses for plant adaptation. However, the underlying molecular mechanisms for plant adaptation remain unclear. Previous studies found that the stem-cell-related mutant clv3-2 has the property of salt tolerance without the differential response of typical stress-responsive genes compared to those in WT Ler. Based on these facts, we hypothesized that shoot meristems contain developmental priming genes having comprehensively converged functions involved in abiotic stress response and development. To better understand the biological process of developmental priming genes in the SAM, we performed RNA sequencing (RNA-seq) and transcriptome analysis through comparing genome-wide gene expression profiles between enriched shoot apex and leaf tissues. As a result, 121 putative developmental priming genes differentially expressed in the shoot apex compared to the leaf were identified under normal and salt stress conditions. RNA-seq experiments also revealed the shoot apex-specific responsive genes for salt stress conditions. Based on combinatorial comparisons, 19 developmental priming genes were finally identified, including developmental genes related to cell division and abiotic/biotic-stress-responsive genes. Moreover, some priming genes showed CLV3-dependent responses under salt stress conditions in the clv3-2. These results presumably provide insight into how shoot meristem tissues have relatively high viability against stressful environmental conditions for the developmental plasticity of plants.
Does Short-Term Combined Irrigation Using Brackish-Reclaimed Water Cause the Risk of Soil Secondary Salinization?
Authors: Liu Chuncheng , Cui Bingjian , Wang Juan , Hu Chao , Huang Pengfei , Shen Xiaojun , Gao Feng , Li Zhongyang
Published: September 2022

Brackish water has to be used to irrigate crops for harvest due to the scarcity of freshwater resources. However, brackish water irrigation may cause secondary soil salinization. Whether the combined utilization of different non-conventional water resources could relieve the risk of secondary soil salinization has not been reported. In order to explore the safe and rational utilization of brackish water in areas where freshwater resources are scarce, a pot experiment was conducted to study the risk of secondary soil mixed irrigation and rotational irrigation using brackish water and reclaimed water or freshwater. The results indicated that: (1) Short-term irrigation using reclaimed water did not cause secondary soil salinization, although increasing soil pH value, ESP, and SAR. The indices did not exceed the threshold of soil salinization. (2) Compared with mixed irrigation using brackish–freshwater, the contents of soil exchangeable Ca2+, K+, and Mg2+ increased, and the content of soil exchangeable Na+ decreased under rotational irrigation using brackish-reclaimed water. In addition, the contents of soil exchangeable Na+ and Mg2+ under mixed irrigation or rotational irrigation were significantly lower, and the exchangeable K+ content of the soil was higher compared with brackish water irrigation. The exchangeable Ca2+ content under rotational irrigation was higher than that of brackish water irrigation, while the reverse was seen under mixed irrigation. (3) For different combined utilization modes of brackish water and reclaimed water, the ESP and SAR were the lowest under rotational irrigation, followed by mixed irrigation and brackish water irrigation. The ESP under brackish water treatment exceeded 15%, indicating a certain risk of salinization, while ESPs under other treatments were below 15%. Under mixed irrigation or rational irrigation using reclaimed-brackish water, the higher the proportion or rotational times of reclaimed water, the lower the risk of secondary soil salinization. Therefore, short-term combined irrigation using brackish water and reclaimed water will not cause the risk of secondary soil salinization, but further experiments need to verify or cooperate with other agronomic measures in long-term utilization.
The Anatomical Basis of Heavy Metal Responses in Legumes and Their Impact on Plant–Rhizosphere Interactions
Authors: Pandey Arun K. , Zorić Lana , Sun Ting , Karanović Dunja , Fang Pingping , Borišev Milan , Wu Xinyang , Luković Jadranka , Xu Pei
Published: September 2022

Rapid industrialization, urbanization, and mine tailings runoff are the main sources of heavy metal contamination of agricultural land, which has become one of the major constraints to crop growth and productivity. Finding appropriate solutions to protect plants and agricultural land from heavy metal pollution/harmful effects is important for sustainable development. Phytoremediation and plant growth-promoting rhizobacteria (PGPR) are promising methods for this purpose, which both heavily rely on an appropriate understanding of the anatomical structure of plants. Specialized anatomical features, such as those of epidermis and endodermis and changes in the root vascular tissue, are often associated with heavy metal tolerance in legumes. This review emphasizes the uptake and transport of heavy metals by legume plants that can be used to enhance soil detoxification by phytoremediation processes. Moreover, the review also focuses on the role of rhizospheric organisms in the facilitation of heavy metal uptake, the various mechanisms of enhancing the availability of heavy metals in the rhizosphere, the genetic diversity, and the microbial genera involved in these processes. The information presented here can be exploited for improving the growth and productivity of legume plants in metal-prone soils.
Phenolic Acids and Flavonoids from Pithecellobium dulce (Robx.) Benth Leaves Exhibit Ovicidal Activity against Haemonchus contortus
Authors: Olmedo-Juárez Agustín , Jimenez-Chino Ana Laura , Bugarin Alejandro , Zamilpa Alejandro , Gives Pedro Mendoza-de , Villa-Mancera Abel , López-Arellano María Eugenia , Olivares-Pérez Jaime , Delgado-Núñez Edgar Jesús , González-Cortazar Manases
Published: September 2022

Pithecellobium dulce (Robx.) Benth is an arboreal legume used in traditional medicine for the treatment of several ailments, including a number of intestinal disorders, and as a natural deworming. The objective of this study was to evaluate the ovicidal activity of a hydroalcoholic extract (HA-E) and its fractions (aqueous, Aq-F and organic, EtOAc-F) from P. dulce leaves, as well as subfractions (C1F1–C17) obtained from EtOAc-F against Haemonchus contortus eggs. The HA-E, Aq-F, and EtOAc-F were assessed at 0.03–5.00 mg/mL and subfractions (C1F1–C17) were assessed at 0.06–1.00 mg/mL. The HA-E and Aq-F showed an ovicidal activity close to 100% at 2.5 mg/mL, and EtOAc-F displayed the highest anthelmintic effect (100% at 0.25 mg/mL). Meanwhile, the sub-fractions with the highest ovicidal effect were C1F6, C1F9, C1F10, C1F11, and CIF13. The main compounds identified in the most active fractions (C1F9, C1F11, and C1F13) were kaempferol (1), quercetin (2), coumaric acid (3), ferulic acid (4), luteolin 7-O-rhamnoside (5), quercetin 3-O-rhamnoside (6), and a caffeoyl derivate (NI). The results indicate that P. dulce leaves exhibit a potent anthelmintic activity and contain bioactive compounds able to inhibit egg hatching in H. contortus. Therefore, this plant could be used for the control of gastrointestinal nematodes in small ruminants.
Cd Phytoextraction Potential in Halophyte Salicornia fruticosa: Salinity Impact
Authors: Salama Fawzy Mahmoud , AL-Huqail Arwa Abdulkreem , Ali Mohammed , Abeed Amany H. A.
Published: September 2022

The phytoextraction potential of halophytes has been broadly recognized. Nevertheless, the impact of salt on the accumulation proprieties of cadmium (Cd) in different halophytic species, likely linked to their salt tolerance, remains unclear. A hydroponic culture was used to investigate the impact of salinity on Cd tolerance as well as accumulation in the distinct halophyte Salicornia fruticosa (S. fruticosa). The plant was subjected to 0, 25, and 50 μg L−1 Cd (0-Cd, L-Cd, and H-Cd, respectively), with or without 50, 100, and 200 mM NaCl in the nutrient solution. Data demonstrated that Cd individually induced depletion in biomass accumulation. NaCl amplified the Cd tolerance induced by enhanced biomass gaining and root length, which was associated with adequate transpiration, leaf succulence, elevated levels of ascorbic acid (ASA), reduced glutathione (GSH), phytochelatins (PCs), and proline as well as antioxidant enzymatic capacity via upregulation of peroxidases (PO), glutathione peroxidase, ascorbate peroxidase, and superoxide dismutase. All Cd treatments decreased the uptake of calcium (Ca) as well as potassium (K) and transport to the shoots; however, sodium (Na) accumulation in the shoots was not influenced by Cd. Consequently, S. fruticosa retained its halophytic properties. Based on the low transfer efficiency and high enrichment coefficient at 0–50 mM NaCl, an examination of Cd accumulation characteristics revealed that phytostabilization was the selected phytoremediation strategy. At 100–200 mM NaCl, the high aboveground Cd-translocation and high absorption efficiency encourage phytoremediation via phytoextraction. The results revealed that S. fruticosa might be also potentially utilized to renovate saline soils tainted with heavy metals (HMs) because of its maximized capacity for Cd tolerance magnified by NaCl. Cd accumulation in S. fruticosa is mainly depending on the NaCl concentration. Future studies may be established for other heavy metal pollutants screening, to detect which could be extracted and/or stabilized by the S. fruticosa plant; moreover, other substrates presenting high electrical conductivity should be identified for reclamation.
Metabolomic Profiling in Combination with Data Association Analysis Provide Insights about Potential Metabolic Regulation Networks among Non-Volatile and Volatile Metabolites in Camellia sinensis cv Baijiguan
Authors: Chen Mingjie , Kong Xiangrui , Zhang Yi , Wang Shiya , Zhou Huiwen , Fang Dongsheng , Yue Wenjie , Chen Changsong
Published: September 2022

The non-volatile and volatile metabolites in tea confer the taste and odor characteristics of tea fusion, as well as shape the chemical base for tea quality. To date, it remains largely elusive whether there are metabolic crosstalks among non-volatile metabolites and volatile metabolites in the tea tree. Here, we generated an F1 half-sib population by using an albino cultivar of Camellia sinensis cv Baijiguan as the maternal parent, and then we quantified the non-volatile metabolites and volatile metabolites from individual half-sibs. We found that the EGC and EGCG contents of the albino half-sibs were significantly lower than those of the green half-sibs, while no significant differences were observed in total amino acids, caffeine, and other catechin types between these two groups. The phenylpropanoid pathway and the MEP pathway are the dominant routes for volatile synthesis in fresh tea leaves, followed by the MVA pathway and the fatty acid-derivative pathway. The total volatile contents derived from individual pathways showed large variations among half-sibs, there were no significant differences between the albino half-sibs and the green half-sibs. We performed a comprehensive correlation analysis, including correlations among non-volatile metabolites, between volatile synthesis pathways and non-volatile metabolites, and among the volatiles derived from same synthesis pathway, and we identified several significant positive or negative correlations. Our data suggest that the synthesis of non-volatile and volatile metabolites is potentially connected through shared intermediates; feedback inhibition, activation, or competition for common intermediates among branched pathways may co-exist; and cross-pathway activation or inhibition, as well as metabolome channeling, were also implicated. These multiple metabolic regulation modes could provide metabolic plasticity to direct carbon flux and lead to diverse metabolome among Baijiguan half-sibs. This study provides an essential knowledge base for rational tea germplasm improvements.
Identification of microRNAs That Provide a Low Light Stress Tolerance-Mediated Signaling Pathway during Vegetative Growth in Rice
Authors: Sekhar Sudhanshu , Das Swagatika , Panda Darshan , Mohanty Soumya , Mishra Baneeta , Kumar Awadhesh , Navadagi Devanna Basavantraya , Sah Rameswar Prasad , Pradhan Sharat Kumar , Samantaray Sanghamitra , Baig Mirza Jaynul , Behera Lambodar , Mohapatra Trilochan
Published: September 2022

Low light intensity affects several physiological parameters during the different growth stages in rice. Plants have various regulatory mechanisms to cope with stresses. One of them is the differential and temporal expression of genes, which is governed by post-transcriptional gene expression regulation through endogenous miRNAs. To decipher low light stress-responsive miRNAs in rice, miRNA expression profiling was carried out using next-generation sequencing of low-light-tolerant (Swarnaprabha) and -sensitive (IR8) rice genotypes through Illumina sequencing. Swarnaprabha and IR8 were subjected to 25% low light treatment for one day, three days, and five days at the active tillering stage. More than 43 million raw reads and 9 million clean reads were identified in Swarnaprabha, while more than 41 million raw reads and 8.5 million clean reads were identified in IR8 after NGS. Importantly, 513 new miRNAs in rice were identified, whose targets were mostly regulated by the genes involved in photosynthesis and metabolic pathways. Additionally, 114 known miRNAs were also identified. Five novel (osa-novmiR1, osa-novmiR2, osa-novmiR3, osa-novmiR4, and osa-novmiR5) and three known (osa-miR166c-3p, osa-miR2102-3p, and osa-miR530-3p) miRNAs were selected for their expression validation through miRNA-specific qRT-PCR. The expression analyses of most of the predicted targets of corresponding miRNAs show negative regulation. Hence, miRNAs modulated the expression of genes providing tolerance/susceptibility to low light stress. This information might be useful in the improvement of crop productivity under low light stress.
Design of Acrylate-Terminated Polyurethane for Nylon Seamless Bonding Fabric Part I: Design of the End-Capping Thermoplastic Polyurethane Adhesive with Acrylate Copolymer
Authors: Chen Jiong-Bo , Lin Sheng-Yu , Ahmad Naveed , Kuo Chung-Feng Jeffrey
Published: September 2022

This series of studies aims to design acrylate-terminated polyurethanes for use in nylon seamless bonded fabrics. The first part used N,N-dimethylacrylamide (DMAA) and methyl methacrylate (MMA) to replace the chain extender in polyurethane synthesis as end-capping agent to synthesize thermoplastic polyurethane (TPU) adhesive. The molecular weight of the TPU is controlled to further influence the mechanical and processing properties of the polyurethane. Here, polytetramethylene ether glycol (PTMG) and 4,4-methylene diphenyl diisocyanate (MDI) were polymerized, and then a blocking agent was added thereto. The results show that the characteristic peaks of benzene ring and carbamate of TPU adhesive are at 1596 cm−1 and 1413 cm−1, respectively, while the characteristic peaks of DMAA are at 1644 cm−1 and 1642 cm−1 in the FT-IR spectrum. There is an absorption peak –N=C=O– which is not shown near 2268 cm−1, which proves that the structure of TPU contains the molecular structure of capping agent, PTMG and MDI. When the DMAA concentration in the capping agent was increased from 3.0 wt% to 10 wt%, the –C=O (H-bond) area percentage of hydrogen bonds formed at 1711 cm−1 increased from 41.7% to 57.6%, while the –NH (H bond) produced at 3330 cm−1 increased from 70% to 81%. These phenomena suggest that increasing the concentration of DMAA capping agent can effectively promote the formation of complex supramolecular network structures by hydrogen bonding in TPU. The content and concentration of the capping agent affects the molecular weight of the TPU. Chain growth is terminated when molecular weight growth can be effectively controlled and reduced. It was observed in thermal analysis that with increasing DMAA concentration in the molecular structure, the concentration of capping agent in TPU, hydrogen bonding force between hard segments, melting point (Tmh) and melting enthalpy (ΔH) all increased the capping agent. The pyrolysis temperature of TPU is increased by 10–20 °C.
Three-Dimensional Dynamic Formation of Second-Order Multi-Agent System Based on Rigid Graphs
Authors: Tian Gailing , Liu Lu , Yang Chenyu , Cui Yu , Hou Kaiyan , Liu Dan , Xue Chenyang
Published: September 2022

This paper studies the dynamic formation control of second-order multi-agent systems (MASs) in three-dimensional space based on the distance control approach. A rigid graph represents the communication topology between agents to improve the system’s robustness and stability and avoid collisions and deformations during formation operation. A distributed control strategy based on the relative states among neighbors is designed for each agent to achieve formation and formation maintenance under arbitrary initial conditions. The Lyapunov function, an error function of potential and kinetic energy, is constructed by rigid graph theory and a second-order integrator model. The decreasing of the Lyapunov function is proven by Barbalat’s theory, further indicating that the system is asymptotically stable. A second-order MAS composed of nine agents is constructed, and the dynamic scaling of rigid formations in 3D space is achieved through simulation to verify the effectiveness of the controller and the correctness of the theory.
The Influence of International Collaboration on the Scientific Impact in V4 Countries
Authors: Kohus Zsolt , Demeter Márton , Szigeti Gyula Péter , Kun László , Lukács Eszter , Czakó Katalin
Published: September 2022

Several strategies are used by researchers and research facilities to increase their scientific production and consequent research quality. Bibliometric records show that coauthorship and the number of participating organizations in research publications are steadily increasing; however, the effect of collaboration varies across disciplines, and the corresponding author’s country appears to influence research impact. This finding inspired our research question for this study: How does international cooperation affect scientific impact, and does the affiliation of corresponding authors influence citation impact indicators at the level of individual publications? To this end, we provide a comparative evaluation of research articles published in Q1 journals among Visegrad Group countries (Czech Republic, Hungary, Poland and Slovakia) in Medical and Health sciences between 2017 and 2021. The study investigates the relationship between collaboration type (national vs. international) and scientific impact (impact factor of the journal and category normalized citation impact or research papers), as well as the impact of the country of the corresponding author’s affiliation on quantitative quality of individual papers. We show that Q1 research papers in international collaboration have a higher scientific impact than papers published in national partnerships. Moreover, the corresponding authors’ country of affiliation significantly affects scientific impact.
Sacred Souvenirs and Divine Curios—Lutherans, Pilgrimage, Saints and the Holy Land in the Seventeenth Century
Authors: Wangsgaard Jürgensen Martin
Published: September 2022

This article explores the surprisingly positive attitude towards pilgrimage and saints that developed within mainstream Lutheran faith during the Seventeenth Century. To acknowledge this strand in the theology of the 1600s in some ways runs contrary to what is often stated about the period, the heyday of Lutheran Orthodoxy, and to a certain extent incompatible with what is generally perceived as ‘Lutheran’. I aim to show the 1600s as a period with a great curiosity towards the development of new devotional practice, and a time when the search for devotional tools which could help the individual to come closer to Christ led theologians to explore texts and ideas that at least superficially could be seen as belonging to the Catholic side of the confessional divide.
Proposal of an Algorithm for Choice of a Development System for Operational and Environmental Safety in Mining
Authors: Khayrutdinov Marat M. , Golik Vladimir I. , Aleksakhin Alexander V. , Trushina Ekaterina V. , Lazareva Natalia V. , Aleksakhina Yulia V.
Published: September 2022

In this paper, a method of mathematical modeling for solving the problem of reusing man-made waste from mining and the processing of ores is proposed. The use of intermediate products (man-made waste: tailings of processing plants, rocks from sinking operations and the technical water of mine drainage) in cyclic production presupposes their use as fill material components and placement in the mined-out voids of underground mines. The influence of mining factors on the fill material composition and the parameters of the created fill mass is justified. The results of a practical implementation of the proposed mathematical model are presented, and an algorithm is compiled. Deformation changes and stress concentration are key criteria in the proposed mathematical model. The proposed algorithm allows for the determination of the preferred system of deposit development, and the selection of its parameters and the fill material composition.
Real-Time Detection of Winter Jujubes Based on Improved YOLOX-Nano Network
Authors: Zheng Zhouzhou , Hu Yaohua , Qiao Yichen , Hu Xing , Huang Yuxiang
Published: September 2022

Achieving rapid and accurate localization of winter jujubes in trees is an indispensable step for the development of automated harvesting equipment. Unlike larger fruits such as apples, winter jujube is smaller with a higher density and serious occlusion, which obliges higher requirements for the identification and positioning. To address the issues, an accurate winter jujube localization method using improved YOLOX-Nano network was proposed. First, a winter jujube dataset containing a variety of complex scenes, such as backlit, occluded, and different fields of view, was established to train our model. Then, to improve its feature learning ability, an attention feature enhancement module was designed to strengthen useful features and weaken irrelevant features. Moreover, DIoU loss was used to optimize training and obtain a more robust model. A 3D positioning error experiment and a comparative experiment were conducted to validate the effectiveness of our method. The comparative experiment results showed that our method outperforms the state-of-the-art object detection networks and the lightweight networks. Specifically, the precision, recall, and AP of our method reached 93.08%, 87.83%, and 95.56%, respectively. The positioning error experiment results showed that the average positioning errors of the X, Y, Z coordinate axis were 5.8 mm, 5.4 mm, and 3.8 mm, respectively. The model size is only 4.47 MB and can meet the requirements of winter jujube picking for detection accuracy, positioning errors, and the deployment of embedded systems.
Ecological Assessment of Terminal Lake Basins in Central Asia under Changing Landscape Patterns
Authors: Yan Wei , Ma Xiaofei , Liu Yuan , Qian Kaixuan , Yang Xiuyun , Li Jiaxin , Wang Yifan
Published: September 2022

Climate change and anthropogenic activities drive the shrinkage of terminal lakes in arid areas to varying degrees. Ecological water conveyance (EWC) projects have emerged globally to restore the ecology of terminal lakes. However, there remains a lack of qualitative evaluation of the benefits of EWC on terminal lakes. This study compared the Taitema Lake Basin with the Aral Sea Basin in Central Asia, representative of terminal lake basins with and without EWC, respectively. The results show that the water area of Taitema Lake increased by 7.23 km2/year due to EWC (2000–2019), whereas that of the Aral Sea Basin decreased by 98.21% over the entire process of natural evolution (1972–2019). Land use changes before and after the EWC (1990–2019) included an increase and decrease in desert land and water bodies in the Aral Sea Basin, and a decrease and increase in desert land and arable land in the Tarim River Basin, respectively. The normalized difference vegetation index (NDVI) and actual evaporation (ETa) are the main factors influencing the change in the water area of the Aral Sea Basin with the changing environment, while EWC is the main factor influencing the change in the water area of Taitema Lake. The results confirm that EWC is a feasible measure for achieving ecological restoration of a terminal lake watershed in an arid area.
Test of Determining Geopotential Difference between Two Sites at Wuhan Based on Optical Clocks’ Frequency Comparisons
Authors: Hoang Anh The , Shen Ziyu , Wu Kuangchao , Ning An , Shen Wenbin
Published: September 2022

Applications of optical clocks in physical geodesy for determining geopotential are of increasing interest to scientists as the accuracy of optical clocks improves and the clock size becomes more and more compact. In this study, we propose a data processing method using the ensemble empirical mode decomposition technique to determine the geopotential difference between two sites in Wuhan based on the frequency comparison of two optical clocks. We use the frequency comparison record data of two Ca+ optical clocks based on the optical fiber frequency transfer method, provided by the Innovation Academy for Precision Measurement Science and Technology, Chinese Academy of Sciences (Wuhan, China). By optical clock comparisons we obtained a geopotential difference of 42.50 ± 1.03 m2∙s−2 (equivalent to height difference of 4.33 ± 0.11 m) between the two sites, which is excellent compared to the geopotential difference of 42.56 ± 0.29 m2∙s−2 (equivalent to height difference of 4.34 ± 0.03 m) measured by a spirit leveling. The results show that the optical fiber frequency transfer method is promising in determining the geopotential and potential for unifying the world height system.
Coordinated Positioning Method for Shortwave Anti-Multipath Based on Bayesian Estimation
Authors: Tang Tao , Jiang Linqiang , Zhao Paihang , Zheng Na-e
Published: September 2022

Coordinated positioning based on direction of arrival (DOA)–time difference of arrival (TDOA) is a research area of great interest in beyond-visual-range target positioning with shortwave. The DOA estimation accuracy greatly affects the accuracy of coordinated positioning. With existing positioning methods, the elevation angle’s estimation accuracy in multipath propagation decreases sharply. Accordingly, the positioning accuracy also decreases. In this paper, the elevation angle is modeled as a random variable, with its probability distribution reflecting the characteristics of multipath propagation. A new coordinated positioning method based on DOA–TDOA and Bayesian estimation with shortwave anti-multipath is proposed. First, a convolutional neural network is used to learn the three-dimensional spatial spectrogram to make an intelligent decision on the number of single and multiple paths, and to obtain a probability distribution of the elevation angle under multiple paths. Second, the elevation angle’s estimated value is modified using the elevation angle’s probability distribution. The modified elevation angle’s estimated value is substituted into a DOA pseudo-linear observation equation, and the target position’s estimated value is obtained using the matrix QR decomposition iteration algorithm. Finally, a TDOA pseudo-linear observation equation is established using the target estimate obtained in the DOA stage, and the coordinated positioning result is obtained using the matrix QR decomposition iteration algorithm again. Simulation results demonstrated that the proposed method had a stronger anti-multipath capability than traditional methods, and it improved the coordinated positioning accuracy of the DOA and TDOA. Measured data were used to validate the proposed method.
Digital Twinning of Hydroponic Grow Beds in Intelligent Aquaponic Systems
Authors: Reyes Yanes Abraham , Abbasi Rabiya , Martinez Pablo , Ahmad Rafiq
Published: September 2022

The use of automation, Internet-of-Things (IoT), and smart technologies is being rapidly introduced into the development of agriculture. Technologies such as sensing, remote monitoring, and predictive tools have been used with the purpose of enhancing agriculture processes, aquaponics among them, and improving the quality of the products. Digital twinning enables the testing and implementing of improvements in the physical component through the implementation of computational tools in a ‘twin’ virtual environment. This paper presents a framework for the development of a digital twin for an aquaponic system. This framework is validated by developing a digital twin for the grow beds of an aquaponics system for real-time monitoring parameters, namely pH, electroconductivity, water temperature, relative humidity, air temperature, and light intensity, and supports the use of artificial intelligent techniques to, for example, predict the growth rate and fresh weight of the growing crops. The digital twin presented is based on IoT technology, databases, a centralized control of the system, and a virtual interface that allows users to have feedback control of the system while visualizing the state of the aquaponic system in real time.
The Gokteik Viaduct: A Tale of Gentlemanly Capitalists, Unseen People, and a Bridge to Nowhere
Authors: Wohlers David C. , Waters Tony
Published: September 2022

This article explores technical and socio-political factors that impacted construction of the Gokteik Viaduct railway bridge in Shan State, Burma, and the recurring failure of political powers to complete a continuous railway between Rangoon (Yangon) and Yunnan. Under rather contentious circumstances, the British government awarded an American steel company with the contract to construct what would become the world’s longest railway trestle bridge at the time of its completion in 1900. As an engineering marvel of its era, the Gokteik Viaduct is in the same category as the Eiffel Tower in Paris. Until now, however, scarce research has explored the Gokteik Viaduct in terms of historicity and factors that ultimately prevented this structure from fulfilling its intended purpose of transporting trainloads of marketable goods between Burma and Yunnan. This raises an ironic question: How could engineers construct such a remarkable bridge to service a railway that was never finished? Furthermore, why does the Gokteik Viaduct largely remain unexamined in terms of its noteworthy place in the geopolitics of Southeast Asia? In answering such questions, the authors conclude that the “unseen” story of the Gokteik Viaduct is not only about engineering prowess but of a political and social environment that continues to bedevil massive infrastructure projects in Upper Burma today.
Tourism Vulnerability Amid the Pandemic Crisis: Impacts and Implications for Rebuilding Resilience of a Local Tourism System in Vietnam
Authors: Huynh Da Van , Duong Long Hai , Nguyen Nhan Trong , Truong Thuy Thi Kim
Published: September 2022

Despite the devastating impact of the COVID-19 crisis on the global tourism industry, a few countries have attempted to foster their local tourism economies’ recovery by offering distinctive mechanisms which facilitate their safe tourism destinations to restart domestic tourism operations during the pandemic waves. However, there has been little research investigating how different sectors of a local tourism system, particularly in a developing country, seriously suffer from the pandemic crisis but gain encouraging revitalization from the pandemic shocks. Therefore, this study employed Can Tho city as a case study to examine the holistic impact of COVID-19 on different sectors of the local tourism industry and explore the key factors/players contributing to the resilience empowerment and adaptive recovery of the local tourism system. As such, a semi-structured interview approach was employed in this study to collect both quantitative and qualitative data. The study recruited 40 representatives of tourism-related authorities at different levels and 280 managers of different tourism sectors in the local tourism industry. The findings generally reveal the disastrous impacts of the pandemic on the local tourism industry across all tourism sectors but show an unexpected recovery of tourism businesses during the pandemic crisis. The integrated findings also highlight the pivotal role of local governments in crisis governance and destination recovery support during and after the pandemic waves. Similarly, the proactive engagement of local enterprises was found critical toward rebuilding their organizational resilience, and such adaptive transformations were essential for tourism business recovery in new normal conditions. The economic policy response and effective financial schemes were common expected measures toward the tourism industry’s recovery in the post-pandemic crisis.
Crime Analysis of the Metropolitan Region of Santiago de Chile: A Spatial Panel Data Approach
Authors: Cadena-Urzúa Pablo , Briz-Redón Álvaro , Montes Francisco
Published: September 2022

The aim of our work is to determine the influence that socio-economic and demographic factors have had on crimes that have taken place during the period 2010–2018 in the communes of the Metropolitan Region of Chile, as well as the existence of possible spatial or temporal effects. We address 12 kinds of crime that we have grouped into two main types: against people and against property. Our interest focuses on crimes against people, using crimes against property as an additional covariate in order to investigate the existence of the broken-windows phenomenon in this context. The model chosen for our analysis is a spatial panel model with fixed effects. The results highlight that covariates such as infant mortality, birth rate, poverty and green areas have a significant influence on crimes against people. Regarding the spatio-temporal covariates, one effect observed is that there is a displacement of crime towards neighbouring communes, leaving open a new line of study to discover the causes of this displacement.
Trainee Teachers’ Perceptions of Socio-Environmental Problems for Curriculum Development
Authors: García-Morís Roberto , Martínez-Medina Ramón
Published: September 2022

Socio-environmental problems are some of the major concerns of today’s society, and education is an essential area to raise awareness and mould future citizens who will be committed to sustainability. The purpose of this paper is to ascertain how future primary and secondary education teachers in the area of social sciences perceive the socio-environmental problems that affect today’s society, for their subsequent inclusion in the curriculum. To this end, a study was carried out by means of a questionnaire, which showed that trainee primary and secondary teachers have a high consideration of these environmental problems, with hardly any differences noted according to sex or type of degree studied. This perception is positive in terms of the subsequent inclusion of socio-environmental problems in the development of the curriculum by the participating trainee teachers, who largely prefer an autonomous model for curricular implementation.
Using 137Cs and 210Pbex to Investigate the Soil Erosion Moduli of the Sandy Area of Typical Grasslands in Northern China
Authors: Guo Xuan , Hu Yunfeng , Zhang Yunzhi , Zhen Lin
Published: September 2022

Soil erosion results in land degradation and desertification in northern China. The Xilingol League of Inner Mongolia is an important part of the “Two Barriers and Three Belts”, and has been given the main function of “a windbreak and sand-fixing belt of northern China”. Accurate measuring of soil erosion moduli, analyzing the differences in soil erosion moduli across different periods and regions, are the basis for carrying out soil conservation and evaluating the effectiveness of ecological governance. Some radioisotopes are good environmental tracers because they are closely combined with the fine particles of the surface soil and are only affected by the mechanical movement of soil particles. In this paper, Taipusi Banner and Zhengxiangbai Banner, which are in the farming–pastoral ecotone in northern China, were selected as the study area. A regional reference inventory, that is, the activity of 137Cs and 210Pbex in the sample without any soil erosion, accumulation/deposition, or any kind of manual disturbances, as well as the soil erosion moduli, were determined by 137Cs and 210Pbex composite tracing technology and multiple lines of evidence. The results are as follows: (1) The regional 137Cs reference inventory was 1928 Bq∙m−2, and the regional 210Pbex reference inventory was 10,041 Bq∙m−2. (2) On a 50-year time scale, the soil erosion moduli in the study area ranged from 140 t∙km−2∙a−1 to 1030 t∙km−2∙a−1; on a 100-year scale, the soil erosion moduli in the study area ranged from 35 t∙km−2∙a−1 to 2637 t∙km−2∙a−1; the entire study area was in a lightly eroded state. (3) Compared with two periods before and after the 1970s, the southern parts (cultivated land and grassland) experienced an increasing trend in soil erosion moduli due to land reclamation, grassland grazing, and other activities. Due to weakening wind and increasing precipitation, soil erosion moduli in the northern parts (southern margin of the Hunshandake Sandy Land) slowed down. The study also discussed the uncertainty and application potential of isotope-tracing technology in sandy land of typical grasslands in northern China.
Business Environment Turbulence and Industrial Connections Instruments as Determinants of Firm Performance Mediated by an Industrial Connections Climate
Authors: Faisal Muhamad , Maarif Mohammad Syamsul , Fahmi Idqan , Yulianto Budi
Published: September 2022

The year 2022 was characterized by several major events that occurred after the COVID-19 pandemic, which devastated business sectors in Indonesia and the rest of the world. The current business environment is experiencing accelerated turbulence characterized by an increasing intensity of business competition, rapid changes in the market, and a changing industrial connections climate. The industrial connection climate of an institution can be measured by the pattern of relationships that occur between workers and management. Industrial connections are fundamental to the sustainability of an organization and are understood as an important factor in influencing institutional performance. This research aims to look at the impact of industrial connections instruments and turbulence in a business environment on the industrial connections climate. In addition, whether the industrial connections climate relates to firm performance was also explored. The research design is inferential and quantitative, and sampling and snowball sampling methods, with a total sample of 406, were used. The data collected were analyzed using a Structural Equation Model using LISREL version 8.70. This research used a survey to build an SEM model that tests the effect of organizational turbulence and industrial connections instruments on organizational climate directly and tested mediation of organizational performance. This research shows that an industrial connections climate has a positive effect on business turbulence and industrial connections instruments. However, industrial connections instruments have a greater impact on the industrial connections climate. This is because industrial connections instruments are the media used in the implementation of industrial connections in organizations. This research also confirms that an industrial connections climate is positively related to organizational performance. The result of the indirect influence (IE) means that the industrial connections climate is able to mediate the influence of industrial connections instruments on organizational performance.
Efficiency Decomposition Analysis of the Marine Ship Industry Chain Based on Three-Stage Super-Efficiency SBM Model—Evidence from Chinese A-Share-Listed Companies
Authors: Guan Hongjun , Wang Yu , Dong Liye , Zhao Aiwu
Published: September 2022

Based on the micro-data of 79 listed companies in the Chinese marine ship industry chain from 2015 to 2019, this paper calculates the comprehensive technical efficiency (TE), pure technical efficiency (PTE), and scale efficiency (SE) of the upstream, midstream, and downstream of China’s marine ship industry chain by using a three-stage super-efficiency slacks-based model (SBM), and further analyzes the weak links in industrial chain efficiency and their influencing factors. It is shown that (i) the TE and PTE of the upstream, midstream, and downstream of China’s marine ship industry chain are in a “V”-shaped distribution, high at both ends and low in the middle, but that the SE is ranked as follows: upstream > midstream > downstream. In addition, the PTE is the main factor which hinders the improvement of TE in the industrial chain. (ii) The environmental variables have significant impacts on industrial chain efficiency. When the influences of environmental variables and random error terms are excluded, the industrial chain efficiency changes significantly. The values of SE and TE decrease significantly, and the distribution characteristic of TE changes. However, the PTE is still in a “V”-shaped distribution and appears to be the main driving force for the progress of TE. (iii) China’s marine ship industry chain has obvious weak links in terms of efficiency, and the midstream and downstream areas need to focus on development. Each link of the industry chain has high coupling and low coordination, and they are all closely related to each other, but the coordination ability is insufficient. The industrial chain in terms of efficiency and coordinated development can still be improved.
Possibility of Sustainable Entry into Overseas Port Operation Markets by Japanese Companies
Authors: Sugimura Yoshihisa , Ishiguro Kazuhiko , Kato Azuma
Published: September 2022

The Japanese government has set an overseas infrastructure deployment policy to involve Japanese companies in all upstream to downstream processes, that is, from project formation, procurement, and construction to operation and maintenance. Although Japanese companies have been hitherto involved in overseas port development through Official Development Assistance, their entry into overseas port operation projects has been limited, meaning the realization of the policy is not expected to be easy. This study thus examines the possibility of sustainable entry into overseas port operation markets by Japanese companies. Specifically, we review port governance in Japan, characteristics of the Japanese market in the global market, and the status of the participation of domestic terminal operators in Japan and overseas, and then identify the possibilities and methods of sustainable inclusion in the future overseas port operations by interviewing representative companies and the government. We finally provide future directions in terms of both increasing entry opportunities and improving the entry environment.
Sustainability Model for the Internet of Health Things (IoHT) Using Reinforcement Learning with Mobile Edge Secured Services
Authors: Rehman Amjad , Saba Tanzila , Haseeb Khalid , Alam Teg , Lloret Jaime
Published: September 2022

In wireless multimedia networks, the Internet of Things (IoT) and visual sensors are used to interpret and exchange vast data in the form of images. The digital images are subsequently delivered to cloud systems via a sink node, where they are interacted with by smart communication systems using physical devices. Visual sensors are becoming a more significant part of digital systems and can help us live in a more intelligent world. However, for IoT-based data analytics, optimizing communications overhead by balancing the usage of energy and bandwidth resources is a new research challenge. Furthermore, protecting the IoT network’s data from anonymous attackers is critical. As a result, utilizing machine learning, this study proposes a mobile edge computing model with a secured cloud (MEC-Seccloud) for a sustainable Internet of Health Things (IoHT), providing real-time quality of service (QoS) for big data analytics while maintaining the integrity of green technologies. We investigate a reinforcement learning optimization technique to enable sensor interaction by examining metaheuristic methods and optimally transferring health-related information with the interaction of mobile edges. Furthermore, two-phase encryptions are used to guarantee data concealment and to provide secured wireless connectivity with cloud networks. The proposed model has shown considerable performance for various network metrics compared with earlier studies.