bluuebunny/crossref_metadata_2025 huggingface dataset:
The relationship between gadolinium enhancement and [18 F]fluorothymidine uptake in brain lesions with the use of hybrid PET/MRI
Authors: Rohan Tomáš , Hložanka Petr , Dostál Marek , Kopřivová Tereza , Macek Tomáš , Vybíhal Václav , Martin Hiroko Jeannette , Šprláková-Puková Andrea , Keřkovský Miloš
Published: August 2024

Background

To evaluate and compare the diagnostic power of [18F]FLT-PET with ceMRI in patients with brain tumours or other focal lesions.

Methods

121 patients with suspected brain tumour or those after brain tumour surgery were enroled in this retrospective study (61 females, 60 males, mean age 37.3 years, range 1–80 years). All patients underwent [18F]FLT-PET/MRI with gadolinium contrast agent application. In 118 of these patients, a final diagnosis was made, verified by histopathology or by follow-up. Agreement between ceMRI and [18F]FLT-PET of the whole study group was established. Further, sensitivity and specificity of ceMRI and [18F]FLT-PET were calculated for differentiation of high-grade vs. low-grade tumours, high-grade vs. low-grade tumours together with non-tumour lesions and for differentiation of high-grade tumours from all other verified lesions.

Results

[18F]FLT-PET and ceMRI findings were concordant in 119 cases (98%). On closer analysis of a subset of 64 patients with verified gliomas, the sensitivity and specificity of both PET and ceMRI were identical (90% and 84%, respectively) for differentiating low-grade from high-grade tumours, if the contrast enhancement and [18F]FLT uptake were considered as hallmarks of high-grade tumour. For differentiation of high-grade tumours from low-grade tumours and lesions of nontumorous aetiology (e.g., inflammatory lesions or post-therapeutic changes) in a subgroup of 93 patients by visual evaluation, the sensitivity of both PET and ceMRI was 90%, whereas the specificity of PET was slightly higher (61%) compared to ceMRI (57%). By receiver operating characteristic analysis, the sensitivity and specificity were 82% and 74%, respectively, when the threshold of SUVmax in the tumour was set to 0.9 g/ml.

Conclusion

We demonstrated a generally very high correlation of [18F]FLT accumulation with contrast enhancement visible on ceMRI and a comparable diagnostic yield in both modalities for differentiating high-grade tumours from low-grade tumours and lesions of other aetiology.
Practical and analytical considerations when performing interim analyses in diagnostic test accuracy studies
Authors: Fleming Susannah , Mwandigha Lazaro , Fanshawe Thomas R.
Published: August 2024

Interim analysis is a common methodology in randomised clinical trials but has received less attention in studies of diagnostic test accuracy. In such studies, early termination for futility may be beneficial if early evidence indicates that a diagnostic test is unlikely to achieve a clinically useful level of diagnostic performance, as measured by the sensitivity and specificity. In this paper, we describe relevant practical and analytical considerations when planning and performing interim analysis in diagnostic accuracy studies, focusing on stopping rules for futility. We present an adaptation of the exact group sequential method for diagnostic testing, with R code provided for implementing this method in practice. The method is illustrated using two simulated data sets and data from a published diagnostic accuracy study for point-of-care testing for SARS-CoV-2. The considerations described in this paper can be used to guide decisions as to when an interim analysis in a diagnostic accuracy study is suitable and highlight areas for further methodological development.
Biomarkers of prostate bladder and testicular cancers: current use in anatomic pathology and future directions
Authors: Morini Mariana Andozia , Athanazio Daniel Abensur , Gallas Luiza Fadul , Mota José Maurício , Bezerra Stephania Martins , Lobo João , Froján María Belén Molina , Acosta Andres
Published: August 2024

Urologic pathology is rapidly evolving to adopt growing knowledge of molecular pathways involved in genitourinary neoplasm. Many prognostic and predictive biomarkers are under active research and some of them have been incorporated in clinical practice. In this review, we will discuss recent developments of Molecular Pathology of prostate, bladder and testicular tumors with special emphasis on prognostic and predictive biomarkers.
A dual-base station constraint method to improve deformation monitoring precision consistency in strip regions
Authors: Hou Cheng , Shi Junbo , Ouyang Chenhao , Guo Jiming , Zou Jingui
Published: August 2024

The precision of deformation monitoring with Global Navigation Satellite System (GNSS) relative positioning is significantly influenced by the distance between the monitoring and base stations. In long strip regions, the considerable differences in station spacing lead to inconsistent monitoring precision among multiple stations. This presents a challenge to accurately model and predict the deformation pattern. To tackle this issue, this paper introduces a novel dual-base station constraint method. This method integrates the baseline length constraint between two base stations into the conventional relative positioning model. The formulae of the proposed method are first derived in detail. Then the data collected at eight monitoring stations in two strip regions of 6 km and 8 km over a 28-day period are used to validate the effectiveness of the proposed method. The quantitative analysis of monitoring precision consistency indicators and hypothesis testing on the correlation between monitoring precision and station spacing are conducted. The results show that: (1) median values of the East, North, and Up consistency indicators are reduced from 2.14, 1.41, and 1.83 to 0.91, 0.67, and 0.55 and from 1.85, 1.85, and 2.32 to 0.69, 1.00, and 0.87, respectively, indicating monitoring precision consistency improvement for two case studies; (2) the absolute values of the correlation coefficients between monitoring precision and station spacing decrease from 0.99, 0.94, and 0.98 to 0.09, 0.36, and 0.32. Using the t-test with a significant level of 0.01, it is demonstrated that there is no significant correlation between monitoring precision and station spacing when employing the proposed method.
Prognostic factors and outcome of relapsed/progressive pediatric Ewing sarcoma: single-center 10-year experience
Authors: Arafah Omar , Hegazy Reem Ragab , Ayadi Moatasem El , Nasr Azza Mohamed , Fawzy Mohamed
Published: August 2024

Background

Ewing sarcoma (ES) is the second most common primary malignant bone tumor in children and adolescents. Despite more intensive chemotherapy regimens and improved local control therapy, there is still a considerable rate of recurrent/progressive disease.

Methods

A retrospective study of 50 relapsed/progressive ES patients who were treated at the National Cancer Institute (NCI), Cairo University, during the period from 1st of January 2008 to the end of December 2018, to assess different prognostic variables and disease outcomes.

Results

Out of fifty eligible cases, 32 patients (64%) had disease recurrence, and 18 (36%) developed disease progression on treatment. The median follow-up period was 7.4 months. The median overall survival (OS) was 7.5 months, and the cumulative OS was 64% at 6 months and 32.6% at 1 year. The cumulative event-free survival (EFS) was 41.3% at 6 months and 22.3% at 1 year. Patients with disease recurrence had better OS and EFS than patients with disease progression (p = 0.019). Patients who underwent local control at relapse/progression had a significantly better outcome than patients who received chemotherapy only (p < 0.001). Recurrence > 2 years from initial diagnosis was the only independent predictor of better survival outcome.

Conclusions

Patients with relapsing/progressive ES portended a poor outcome, with disease progression on treatment faring worse than relapse. Better outcome was observed in patients who experienced recurrence > 2 years after diagnosis, patients with disease recurrence rather than disease progression on treatment, and patients who underwent local control along with intensive chemotherapy.
The temporal-spatial association of respiratory manifestations and air pollution in children referred to the Emergency Department of Akbar Children’s Hospital, Mashhad, Iran
Authors: Moazzen Nasrin , Memari Amirreza , Todarbary Nafiseh
Published: August 2024

Background

Air pollution causes many respiratory disorders, especially in children and the elderly. These disorders include asthma exacerbations, bronchiolitis, and pneumonia. Research on the association between air pollution and respiratory disorders helps to reevaluate environmental policies in developing countries.

Methods

This descriptive cross-sectional study was conducted on 932 children with respiratory manifestations admitted from December 2017 to December 2019 at the Emergency Department of Akbar Children’s Hospital of Mashhad University of Medical Sciences, Mashhad, Iran. Air pollution indices such as concentration of sulfur dioxide (SO2), nitrogen dioxide (NO2), carbon monoxide (CO), and particulate matter (PM) smaller than 2.5 and 10 μm and other parameters, including the air quality index (AQI), air temperature, and humidity level from 2017 to 2019, were retrieved from Mashhad Environmental Pollution Monitoring Center. Demographic and clinical data of patients were collected from patients’ hospital documents. We used descriptive analytical methods such as central tendency, variability, and frequency distribution to report and analyze demographic and clinical data through tables and diagrams. The association between air pollution indices and respiratory manifestations was examined by the Spearman correlation test. The correlation between the AQI and total hospital admissions and asthma-related hospital admissions was also evaluated by the Spearman correlation test.

Results

Hospital admissions due to respiratory manifestations were not associated with the AQI of each month (p-value = 0.794). The concentration of SO2 was correlated with respiratory-related hospital admissions (correlation coefficient = 0.487, p-value = 0.016) but not asthma attacks.

Conclusion

Generally, our cross-sectional study showed no statistically considerable association between air pollution and hospital admissions due to respiratory manifestations and asthma attacks in children. Of the air pollution indices, only SO2 concentration was associated with respiratory-related hospital admissions but not asthma attacks.
Can a fast T2-Dixon sequence surpass the time obstacle of whole-body MRI in the evaluation of skeletal metastases?
Authors: Elmansy Mostafa , Magdi Noha , Elhawary Mohammed A. , Sultan Amina
Published: August 2024

Background

Whole-body magnetic resonance imaging (WB-MRI) has shown its accuracy in the diagnosis of skeletal metastases in patients with known primary solid cancers. The standard protocol was a combination of T1 and short tau inversion recovery (STIR) sequences. Herein, this study was conducted to elucidate the role of the T2-Dixon sequence as a rapid alternative to the standard protocol with the assessment of its diagnostic accuracy and comparability to the established methodology.

Methods

This prospective study included 30 patients with primary solid malignancies who underwent WB-MRI. The sequences obtained were T1WI, STIR, and T2-Dixon (fat-only and water-only images). Skeletal metastases were evaluated in each sequence. Results were compared between the T1-STIR combination and T2-Dixon fat and water reconstructions.

Results

The sensitivity of fat and water reconstructions from a single T2-Dixon in the detection of lytic skeletal metastases was marginally superior to a combination of T1WI and STIR sequences (0–7%). Detection of mixed lesions demonstrated equally high sensitivity in both protocols. Sclerotic metastases detection in WB-MRI showed low sensitivity in both protocols. However, specificity surpassed 95% for all lesion types in both protocols. Overall image quality was favored (in 87–90% of patients) in T2-Dixon images. The overall estimated acquisition timing using T2-Dixon appeared to be approximately half that of the standard T1-STIR combination.

Conclusions

WB-MRI using T2-Dixon fat and water reconstructions showed similar accuracy to T1WI and STIR combination in the evaluation of skeletal metastases in patients with primary solid cancers with significantly shorter acquisition time.
Unusual cause of incomplete cauda equina syndrome: dermoid cyst with a split cord malformation case report
Authors: Retal Hamza , EL Graini Soumya , EL Ouazzani Hafsa , Cherradi Nadia , Fikri Meriem , Echcherif El Kettani Najwa , Jiddane Mohamed , Touarsa Firdaous
Published: August 2024

Cauda equina syndrome is a surgical emergency caused by the compression of the lumbosacral nerves. The most frequent cause is discal herniation, while tumoral pathology in this region is rare, and congenital processes are less common. We report the case of a young 37-year-old male patient, admitted to the emergency room with an incomplete cauda equina syndrome. As medical history, a lumbar surgery 15 years ago was reported with no documentation. An MRI was performed, revealing a mass within the filum terminal exhibiting three components suggestive of a dermoid cyst accompanying a split cord malformation, which was confirmed by pathology. Various disorders may be associated to intradural dermoid cyst, such as lipoma, low-lying cord, hydromyelia or thick filum. Surgery is the treatment of choice, and MRI plays a crucial role in detecting associated abnormalities and determining surgery priorities.
Myeloid sarcoma, spectrum of clinical characteristics, prognostic impact, and treatment outcome
Authors: Semary Samah Fathy , Hammad Mahmoud , Soliman Sonya , Hamdy Nayera , Salem Sherine , zaky Iman , elkinaai Naglaa , Ezzat Nermeen , Albeltagy Doaa , Madany Youssef
Published: August 2024

Background

Acute leukemia may present with extramedullary (EM) tissues. Myeloid sarcoma (MS) and leukemia cutis (LC) are considered extramedullary diseases. This study aims to evaluate the incidence, clinical characteristics, and prognostic factors affecting the outcome of pediatric patients with myeloid sarcoma at the pediatric oncology center from July 2007 to December 2017. Radiological imaging was used to stage the tumor, biopsy was done for pathological diagnosis, and bone marrow aspirate for morphology, flow cytometry, cytogenetics, and molecular analysis. Patients received chemotherapy protocols based on those used by the Children's Cancer Group for acute myeloid leukemia (AML).

Result

The study included 91 (13.2%) of 687 pediatric patients with acute myeloid leukemia, with a male-to-female ratio of 1.9 to 1. Prognostic factors that improved the patient’s 5-year overall survival (OS) were age > 5 years old, molecular and cytogenetic detection of t (8; 21), inv 16, presence of a single and small size lesion < 5 cm, negative CNS lesion, and achieved radiological response in isolated disease or radiological and marrow complete remission in disseminated disease post induction 1 with significant P value. Relapse, particularly early relapse, worsens the OS and EFS by 10% and 7.7%, respectively.

Conclusion

Patients over five with low-risk disease based on cytogenetics, a small, single, negative CNS lesion, and a complete response post induction 1 had better outcomes, with no significant difference between those with isolated extramedullary disease and those with marrow dissemination. Early relapse harms the outcome. The study group’s 5-year OS and EFS rates are 51.4% and 49.4%, respectively.
An investigation of deep learning approaches for efficient assembly component identification
Authors: Ramesh Kaki , Mushtaq Faisel , Deshmukh Sandip , Ray Tathagata , Parimi Chandu , Basem Ali , Elsheikh Ammar
Published: August 2024

Background

Within the manufacturing sector, assembly processes relying on mechanical fasteners such as nuts, washers, and bolts hold critical importance. Presently, these fasteners undergo manual inspection or are identified by human operators, a practice susceptible to errors that can adversely affect product efficiency and safety. Given considerations such as time constraints, escalating facility and labor expenses, and the imperative of seamless integration, the integration of machine vision into assembly operations has become imperative.

Results

This study endeavors to construct a robust system grounded in deep learning algorithms to autonomously identify commonly used fasteners and delineate their attributes (e.g., thread type, head type) with acceptable precision. A dataset comprising 6084 images featuring 150 distinct fasteners across various classes was assembled. The dataset was partitioned into training, validation, and testing sets at a ratio of 7.5:2:0.5, respectively. Two prominent object detection algorithms, Mask-RCNN (regional-based convolutional neural network) and You Look Only Once-v5 (YOLO v5), were evaluated for efficiency and accuracy in fastener identification. The findings revealed that YOLO v5 surpassed Mask-RCNN in processing speed and attained an mean average precision (MAP) of 99%. Additionally, YOLO v5 showcased superior performance conducive to real-time deployment.

Conclusions

The development of a resilient system employing deep learning algorithms for fastener identification within assembly processes signifies a significant stride in manufacturing technology. This study underscores the efficacy of YOLO v5 in achieving exceptional accuracy and efficiency, thereby augmenting the automation and dependability of assembly operations in manufacturing environments. Such advancements hold promise for streamlining production processes, mitigating errors, and enhancing overall productivity in the manufacturing sector.
Ethnopharmacology and therapeutic potentials of Oxalis corniculata: an in-depth study
Authors: Bharti Ram , Priyanka Priyanka , Bhargava Prachi , Khatri Neeraj
Published: August 2024

Background

For centuries, plants have been used in the folk medicine of various cultures for their healing properties. It is amazing how nature has provided us with such powerful remedies. Oxalis corniculata (O. corniculata) has always been used traditionally for its medicinal attributes. In Asia, this herbaceous plant is used for treating many gastrointestinal disorders, such as diarrhea and dysentery. In African folk medicine, on the other hand, this herb is used for respiratory diseases, skin diseases, and fever.

Main body

Scientific research has revealed numerous pharmacological potentials of this plant, including antitumor, antimicrobial, antioxidant, anti-inflammatory, and hepatoprotective properties. In addition, studies have indicated that the extract of this plant protects against oxidative stress, inflammation, and various diseases, including cancer and diabetes. Phytochemical analysis of O. corniculata revealed various relevant compounds, including phenolic acids, flavonoids, and alkaloids, which are responsible for its therapeutic properties.

Conclusion

The various constituents of this plant have significant ethnomedicinal potential. The plant is a possible source of extracts and chemical compounds with pharmacological activity. In the future, O. corniculata could have an effective role in the development of modern drugs. The objective of this review is to summarize the current knowledge on the medicinal potential of O. corniculata, including its bioactive compounds, mechanisms of action, and therapeutic applications.

Graphical abstract
A challenging coexistence: community-acquired methicillin-resistant Staphylococcus aureus and Mycobacterium tuberculosis
Authors: Afşin Emine , Sümbül Aslı , Gülözer Adem Emre
Published: August 2024

Background

Community-acquired Methicillin-resistant Staphylococcus aureus (CA-MRSA) usually emerges after a viral infection and causes severe disease in immunocompetent individuals. Concurrent infection with tuberculosis (TB) is generally very rare in immunocompetent patients. Our case is the first report of the coexistence of CA-MRSA and TB in an immunocompetent patient.

Case presentation

A 24-year-old male patient of African origin, who has been living in Turkey for a year, was admitted to our hospital 3 months ago with fever, cough, and sputum complaints, which developed following symptoms of influenza infection. More intense bilateral infiltration and cavitary appearance were observed on the left in the chest radiography of the patient who did not respond to amoxicillin and gemifloxacin treatments. The patient’s sputum culture showed MRSA growth, and his sputum acid-resistant bacteria (ARB) was reported as three positive. Vancomycin, isoniazid, rifampicin, pyrazinamide, and ethambutol treatments were started. Subsequently, Mycobacterium Tuberculosis growth was also detected in the mycobacteria culture. Vancomycin treatment was completed in 14 days. There was no growth in the control sputum culture. When the patient, who gave clinical and laboratory response, was admitted with increased shortness of breath complaint two months after discharge, it was observed that minimal spontaneous pneumothorax developed in the left lung, and it was decided to follow up without intervention. In the second month of tuberculosis treatment, sputum ARB and mycobacteria culture became negative, and the patient was switched to dual antituberculosis treatment (isoniazid, rifampicin), and his treatment is still ongoing.

Conclusions

Mixed infections should be considered in case of non-response to treatment in patients with pneumonia. Mixed infections should also be followed closely as they may be more complicated.
Identification of microRNA and their potential role in regulation diapause termination in seven spot ladybird beetle,
Coccinella septempunctata
Authors: Wu Mengmeng , Xiao Da , Lin Jing , Zhang Junming , Zang Liansheng , Wang Su
Published: August 2024

Diapause is an alternative development stage in seven spot ladybird beetle,
Coccinella septempunctata
. However, the regulatory mechanism governing the initiation, maintenance, and termination of diapause in the seven-spot ladybird have not been extensively studied. MicroRNAs (miRNAs), a type of non-coding RNA, might be involved in diapause regulation and related physiological processes. The objective of this study is to investigate the potential involvement of miRNAs in diapause termination in
C. septempunctata
. High-throughput sequencing was used to identify miRNAs associated with diapause termination in
C. septempunctata
. A total of 769 miRNAs were identified, potentially implicated in diapause termination, including 673 evolutionarily conserved miRNA and 96 putatively novel-miRNAs. Among these, two evolutionarily conserved miRNAs, aae-miR-305-5P and tca-miR-277-5P, exhibited differential abundance during diapause termination compared to diapause. aae-miR-305-5P was overexpressed in diapause termination ladybird beetle and may be responsible for silencing the expression of candidate genes in peroxisome pathway associated with diapause termination. Conversely, tca-miR-277-5P was under-expressed in diapause termination and may promote the expression of genes related to the longevity regulating pathway, thereby increase the lifetime, a characteristic feature of diapause termination. In addition, a putatively novel-miRNA (unconservative_c62764) was overexpressed in diapause termination ladybird beetle, potentially contributing to the decreased expression of genes related to Wnt signaling pathway during diapause termination. These findings highlighting the significant roles of microRNAs in pathway such as longevity regulation, perisome function, and Wnt signaling, which may regulate diapause termination in
C. septempunctata
. This study might help us to unveil the miRNA involvement in gene expression regulation of diapause termination in insects.
METTL Family in Health and Disease
Authors: He Jiejie , Hao Fengchen , Song Shiqi , Zhang Junli , Zhou Hongyu , Zhang Jun , Li Yan
Published: August 2024

Transcription, RNA splicing, RNA translation, and post-translational protein modification are fundamental processes of gene expression. Epigenetic modifications, such as DNA methylation, RNA modifications, and protein modifications, play a crucial role in regulating gene expression. The methyltransferase-like protein (METTL) family, a constituent of the 7-β-strand (7BS) methyltransferase subfamily, is broadly distributed across the cell nucleus, cytoplasm, and mitochondria. Members of the METTL family, through their S-adenosyl methionine (SAM) binding domain, can transfer methyl groups to DNA, RNA, or proteins, thereby impacting processes such as DNA replication, transcription, and mRNA translation, to participate in the maintenance of normal function or promote disease development. This review primarily examines the involvement of the METTL family in normal cell differentiation, the maintenance of mitochondrial function, and its association with tumor formation, the nervous system, and cardiovascular diseases. Notably, the METTL family is intricately linked to cellular translation, particularly in its regulation of translation factors. Members represent important molecules in disease development processes and are associated with patient immunity and tolerance to radiotherapy and chemotherapy. Moreover, future research directions could include the development of drugs or antibodies targeting its structural domains, and utilizing nanomaterials to carry miRNA corresponding to METTL family mRNA. Additionally, the precise mechanisms underlying the interactions between the METTL family and cellular translation factors remain to be clarified.
A detailed study on optimizing DMLS process parameters to enhance AlSi10Mg metal component properties
Authors: Kunisetti Pragnya , Prasad Balla Srinivasa
Published: August 2024

This study investigates the effects of laser power, scan speed, and hatch distance on the features of aluminium specimens produced using direct metal laser sintering (DMLS). By systematically varying these parameters, we identified optimal combinations for producing high-quality metal components. Our findings were validated through reproducible printing processes. Analysis of variance (ANOVA) and grey relational analysis (GRA) were employed to optimize the production parameters further. We found a significant trade-off between laser power, tensile strength, and fatigue resistance, with laser power having the most substantial impact on mechanical properties, microstructure, and surface roughness. Statistical analysis confirmed that higher laser power improves mechanical characteristics but may increase surface roughness. These insights are crucial for enhancing the efficiency and quality of DMLS-produced metal components.
Epidemiology of gonorrhea in countries of the Middle East and North Africa: systematic review, meta analyses, and meta regressions
Authors: Chemaitelly Hiam , Harfouche Manale , Smolak Alex , Ageeb Rwedah , Mohamoud Yousra A. , Alaama Ahmed S. , Hermez Joumana G. , Abu-Raddad Laith J.
Published: August 2024

Background

The epidemiology of Neisseria gonorrhoeae (NG) infection in the Middle East and North Africa (MENA) region remains poorly understood, despite the global recognition of its disease burden and the growing concern regarding antimicrobial resistance. This study aimed to systematically review the evidence on NG prevalence in MENA, estimate the pooled mean prevalence across different populations, and explore population-level associations with prevalence as well as sources of between-study heterogeneity.

Methods

The study conducted a systematic review, risk of bias assessment, meta-analyses, and meta-regressions, utilizing both published and unpublished evidence sourced from international, regional, and national databases, in adherence to PRISMA guidelines. Random-effects meta-analyses and meta-regressions were employed to analyze the data.

Results

The study identified 341 NG prevalence measures from 21 countries in MENA. The pooled mean prevalence of current urogenital infection was 1.9% (95% confidence interval (CI) 1.1–2.8%) in the general population, with a higher pooled prevalence in studies with sample sizes < 200 (3.1%; 95% CI 1.5–5.0%) compared to those with sample sizes ≥ 200 (1.1%; 95% CI 0.5–1.9%). Among specific populations, the pooled prevalence was 6.5% (95% CI 4.4–9.0%) in female sex workers, 7.5% (95% CI 2.8–14.0%) in attendees of infertility clinics, 3.0% (95% CI 0.4–7.0%) in women with miscarriage or ectopic pregnancy, 3.9% (95% CI 2.7–5.3%) in symptomatic women, and 41.4% (95% CI 34.9–48.1%) in symptomatic men. For male sex workers and men who have sex with men, the pooled prevalence of current urogenital infection was 1.6% (95% CI 0.4–3.4%), while the prevalence of current anorectal infection was 10.4% (95% CI 4.6–18.0%). Through multivariable meta-regressions, 64% of the prevalence variation was explained, revealing a hierarchical pattern in prevalence by population type and sex, and a prevalence decline at a rate of 1% per year.

Conclusions

NG prevalence in MENA is comparable to the global prevalence, underscoring a neglected and underrecognized disease burden, with social and economic consequences. Persistent transmission of NG among key populations and other populations at risk increases the potential for the emergence of new drug-resistant strains. MENA is far from achieving the World Health Organization’s target of reducing NG incidence by 90% by 2030.
Community-Led Action Research in Oncology: Pandemic-Appropriate Radiotherapy Innovations Evaluated (CLARO PARTE) for Latin America and the Caribbean Countries
Authors: Riano Ivy , Alas-Pineda César , Reyes Garcia Sarahi , Murillo Raúl , Gutiérrez-Delgado Francisco , Cazap Eduardo , Pais Viegas Celia Maria , Torre Marcela de la , Barahona Kaory C. , Sarria Gustavo J. , del Castillo Bahi Ramón , Luongo-Céspedes Álvaro , Ovalles Beatriz , Umaña Herrera Flory Vanessa , Sánchez Ricardo , McVorran Shauna , Williams Benjamin , Kascmar Joseph , Kennedy Linda S. , Lyons Kathleen D. , Bejarano Suyapa , Wong Sandra L.
Published: August 2024

PURPOSE

This study aimed to identify, evaluate, and rank suitable safety innovations developed during the COVID-19 pandemic in Latin American and Caribbean (LAC) radiation oncology centers.

METHODS

We conducted a multimodal participatory engagement collaboration with the Latin-American and Caribbean Society of Medical Oncology. The study consisted of four phases. Innovations were collected from a panel of radiotherapy experts representing a diverse group of 11 countries from LAC (Phase I). Next, a medical scientific team compared the innovations against international standards regarding their potential impact on risk of infection, clinical operation, and continuity of quality cancer care (Phase II). Their findings were supplied to the country representatives who rated the innovations for acceptability in their cancer centers (Phase III), resulting in a final report of the panel's recommendations (Phase IV).

RESULTS

A total of 81 innovations were reported by the country representatives and merged by the medical scientific team into 24 innovations that combined similar innovations. The 24 innovations were grouped into six categories including practices aimed at (1) reducing clinic crowding (n = 3), (2) increasing screening and vaccinations for COVID-19 disease (n = 5), (3) implementing social distancing (n = 6), (4) strengthening personal infection equipment and disinfection (n = 6), (5) avoiding delaying or shortening treatment protocols (n = 2), and (6) mixed procedures (n = 2). The medical scientific team found nearly all innovations were supported by international recommendations and rated as safe, efficient, and acceptable.

CONCLUSION

By using the lessons learned from the Community-Led Action Research in Oncology: Pandemic-Appropriate Radiotherapy Innovations Evaluated study, a manual of scalable practices in radiation oncology clinics may be developed to guide actions during future large-scale public health crises in low- and middle-income countries of LAC.
Performance of Low-Dose Immunotherapy and Standard-Dose Immunotherapy in Microsatellite Instability-High Metastatic Colorectal Cancer: Real-World Data (CLouD—High Study)
Authors: Trikha Mehak , Sarkar Laboni , Dhanawat Aditya , Syed Noorzia , Gujarathi Himanshu , Vora Manan , Sivakumar Raja A. Sree , Bhargava Prabhat , Ramaswamy Anant , Mandavkar Sarika , Saklani Avanish , Kaushal Rajiv Kumar , Bal Munita , Shetty Omshree , Yadav Subhash , Ostwal Vikas
Published: August 2024

PURPOSE

Standard-dose immune checkpoint inhibitors (SD-ICIs) are the standard of care as initial therapy in microsatellite instable-high (MSI-H) advanced/metastatic colorectal adenocarcinomas (mCRC), but there are preclinical data to suggest that low-dose ICIs (LD-ICI) might also have similar efficacy.

MATERIALS AND METHODS

A retrospective study of patients with MSI-H mCRC receiving ICIs between June 2017 and January 2023 was conducted. The primary end point of the study was 12-month progression-free survival (PFS), which was computed using the Kaplan-Meier method.

RESULTS

A total of 65 patients were available for analysis during the study period. Sixty patients (92%) received nivolumab, whereas the remaining received pembrolizumab. First-line ICIs were received by 18 patients (28%), whereas 47 patients (72%) received ICIs during later lines. Thirty patients (47%) received LD-ICIs (all received nivolumab), with the remaining receiving SD-ICIs (53%). At a median follow-up of 16.5 (95% CI, 11.8 to 21.2) months, median PFS was not reached in the entire cohort. The 12-month PFS rate in the LD-ICI cohort was 90%, whereas it was 75.8% in the SD-ICI cohort. There were no statistical differences in patients receiving ICIs as first-line therapy (12 months PFS—94.4%) or during later lines of therapy (12-month PFS—77.9%; P = .56).

CONCLUSION

ICIs in the current study show survivals which are similar to those seen in seminal trials in patients with MSI-H mCRC. Low-dose ICIs appear to work in MSI-H mCRC and should be explored prospectively in clinical trials. Patients with MSI-H status should be exposed to ICIs, whether initially or later during treatment, whenever feasible.
Plantation Worlds
Authors: Barua Maan
Published: August 2024

In Plantation Worlds, Maan Barua interrogates debates on planetary transformations through the histories and ecologies of plantations. Drawing on long-term research spanning fifteen years, Barua presents a unique ethnography attentive to the lives of both people and elephants amid tea plantations in the Indian state of Assam. In the nineteenth and early twentieth centuries, nearly three million people were brought in to Assam’s plantations to work under conditions of indenture. Plantations dramatically altered the region’s landscape, plundered resources, and created fraught worlds for elephants and people. Their extractive logics and colonial legacies prevail as durations, forging the ambit of infrastructures, labor, habitability, and conservation in the present. And yet, as the perspectives of the Adivasi plantation worker community and lifeworlds of elephants show, possibilities for enacting a decolonial imaginary of landscape remain present amid immiseration. From the margins of the Global South, Barua offers an alternative grammar for articulating environmental change. In so doing, he prompts a rethinking of multispecies ecologies and how they are structured by colonialism and race.
Six Paintings from Papunya
Authors: Myers Fred R. , Smith Terry
Published: August 2024

In the early 1970s at Papunya, a remote settlement in the Central Australian desert, a group of Indigenous artists decided to communicate the sacred power of their traditional knowledge to the wider worlds beyond their own. Their exceptional, innovative efforts led to an outburst of creative energy across the continent that gave rise to the contemporary Aboriginal art movement that continues to this day. In their new book, anthropologist Fred Myers and art critic Terry Smith discuss six Papunya paintings featured in a 2022 exhibition in New York. They draw on several discourses that have developed around First Nations art—notably anthropology, art history, and curating as practiced by Indigenous and non-Indigenous interpreters. Their focus on six key paintings enables unusually close and intense insight into the works’ content and extraordinary innovation. Six Paintings from Papunya also includes a reflection by Indigenous curator and scholar Stephen Gilchrist, who reflects on the nature and significance of this rare transcultural conversation.
Minimally Destabilizing Corridor for Resection of Dumbbell Nerve Sheath Tumors: A Novel Surgical Technique
Authors: Maragkos Georgios A. , Kurker Kristina P. , Yun Jonathan , Yen Chun-Po , Asthagiri Ashok R.
Published: August 2024

BACKGROUND AND OBJECTIVES:

Current surgical strategies for dumbbell nerve sheath tumors (DNSTs) with cord compression have primarily involved wide spinal exposures with total laminectomy and unilateral facetectomy, often leading to spinal destabilization and requiring fusion, or staged procedures separately addressing the intraspinal and extraforaminal tumor components. This study highlights technical nuances of a novel approach for DNST resection to minimize spinal destabilization and avoid fusion while facilitating safe, single-stage complete resection.

METHODS:

A retrospective chart review was conducted on patients undergoing DNST resection. Using unilateral subperiosteal dissection, hemilaminotomy and medial facetectomy procedures are performed. The extradural tumor component is resected, followed by internal decompression of the intradural tumor. A small horizontal incision at the origin of the nerve root sleeve releases the underlying dural stricture, facilitating delivery of the remaining intradural tumor and allowing section of the nerve root of origin. Ultrasonography confirms complete tumor resection and return of cord pulsation, and excludes intradural hemorrhagic complications. The dura is reconstructed using a dural substitute bolstered with fat graft and sealant.

RESULTS:

Twelve consecutive patients undergoing this approach from 2014 to 2021 were included. Mean patient age was 53.5 years, and 58.3% were male. Nine tumors were cervical and 3 were lumbar. Five patients presented with myelopathy, 4 with radiculopathy, and 4 with axial pain. Two cases had transient intraoperative neuromonitoring signal changes. Eleven tumors were diagnosed as schwannomas and 1 as neurofibroma. All patients had complete resection of the intraspinal component; 2 had far distal extraforaminal residual. No patient has had recurrence, progression of residual, or signs of spinal instability during follow-up (median 28.5 months, range 6-66 months).

CONCLUSION:

This study highlights technical considerations for DNST resection, focusing the approach at the center of the tumor, with minimal bone removal and ligamentous disruption. Intraoperative ultrasound is instrumental in the safety of this approach.
An atlas of Brachypodium distachyon lateral root development
Authors: de Jesus Vieira Teixeira Cristovāo , Bellande Kevin , van der Schuren Alja , O'Connor Devin , Hardtke Christian S. , Vermeer Joop E. M
Published: August 2024

The root system of plants is a vital part for successful development and adaptation to different soil types and environments. A major determinant of the shape of a plant root system is the formation of lateral roots, allowing for expansion of the root system. Arabidopsis thaliana, with its simple root anatomy, has been extensively studied to reveal the genetic program underlying root branching. However, to get a more general understanding of lateral root development, comparative studies in species with a more complex root anatomy are required. Here, by combining optimized clearing methods and histology, we describe an atlas of lateral root development in Brachypodium distachyon, a wild, temperate grass species. We show that lateral roots initiate from enlarged phloem pole pericycle cells and that the overlying endodermis reactivates its cell cycle and eventually forms the root cap. In addition, auxin signaling reported by the DR5 reporter was not detected in the phloem pole pericycle cells or young primordia. In contrast, auxin signaling was activated in the overlying cortical cell layers, including the exodermis. Thus, Brachypodium is a valuable model to investigate how signaling pathways and cellular responses have been repurposed to facilitate lateral root organogenesis.
Uncovering developmental diversity in the field
Authors: Brown Federico D. , Ishengoma Edson , Mayer Georg , Pabón-Mora Natalia , Santos M. Emília , Sears Karen E. , de Sena Oliveira Ivo
Published: August 2024

Many developmental biologists seldom leave the lab for research, relying instead on establishing colonies of traditional and emerging model systems. However, to fully understand the mechanisms and principles of development and evolution, including the role of ecology and the environment, it is important to study a diverse range of organisms in context. In this Perspective, we hear from five research teams from around the world about the importance and challenges of going into the field to study their organisms of interest. We also invite you to share your own fieldwork stories on the Node.
Barometric pressure decrease induces density-dependent changes in foraging behaviour in a parasitoid fly
Authors: Houchat Jean-Noël , Castelo Marcela K. , Crespo José E.
Published: August 2024

Barometric pressure is an environmental factor involved in the modulation of a variety of activities in insects. Generally, a drop in barometric pressure precedes the arrival of weather conditions that can affect insect activities and life expectancy. We simulated different scenarios of pressure drop in a modified hermetic chamber and studied their influence on the host-seeking behaviour of the larvae of the robber fly Mallophora ruficauda using air stationary olfactometers. In addition, we studied whether larval density modulates orientation to the host under the same scenarios of pressure drop. We found that motivation to search for hosts is affected by the same slope of pressure drop in both low- and high-density larvae. However, larval density modulates the onset of the responses to pressure decrease, as low-density larvae stop searching for hosts more quickly than high-density larvae. This result reflects an avoidance strategy according to which low-density larvae would have a reduced host range and higher risk of mortality and fewer chances to find a suitable host under adverse pressure conditions. Low-density larvae, known to prefer healthy hosts, do not search for parasitized hosts under normal pressure conditions nor under a range of pressure drops, strongly suggesting that host selectivity is not modulated by barometric pressure. This study paves the way to a better understanding of the changes in crucial insect behaviours induced by weather conditions, and provides more knowledge about the risk factors likely to affect insect survival in the context of foraging ecology.
Born suckers: the cibarial pump of Philaenus spumarius scales across ontogeny to ensure functional equivalence
Authors: Bergman Elisabeth A. , Matthews Philip G. D.
Published: August 2024

A select group of hemipterans within the suborder Auchenorrhyncha are the only animals that feed exclusively on xylem sap – a nutritionally poor liquid that exists under negative pressure within a plant's xylem vessels. To consume it, xylem-feeding bugs have evolved enlarged cibarial pumps capable of generating enormous negative pressures. A previous study examining the allometry of this feeding model suggested that small xylem feeders pay relatively higher energetic costs while feeding, favouring the evolution of larger-bodied species. However, this interspecific analysis only considered adult xylem-feeding insects and neglected the considerable intraspecific change in size that occurs across the insect's development. Here, we examine the changes in cibarial pump morphology and function that occur during the development of Philaenus spumarius, the common meadow spittlebug. We show that the cibarial pump scales largely as expected from isometry and that the maximum negative pressure is mass independent, indicating that size has no effect on the xylem-feeding capacity of juvenile spittlebugs. We conclude that a first instar nymph with a body mass 2% of the adult can still feed at the >1 MPa tension present in a plant's xylem vessels without a substantial energetic disadvantage.
The Association of Established Primary Care with Postoperative Outcomes Among Medicare Patients with Digestive Tract Cancer
Authors: Katayama Erryk S. , Thammachack Razeen , Woldesenbet Selamawit , Khalil Mujtaba , Munir Muhammad Musaab , Tsilimigras Diamantis , Pawlik Timothy M.
Published: August 2024

Background

Primary care (PC) is essential to overall wellness and management of comorbidities. In turn, patients without adequate access to PC may face healthcare disparities. We sought to characterize the impact of established PC on postoperative outcomes among patients undergoing a surgical procedure for a digestive tract cancer.

Methods

Medicare beneficiaries with a diagnosis of hepatobiliary, pancreas, and colorectal cancer between 2005 and 2019 were identified within the Surveillance, Epidemiology, and End Results program and Medicare-linked database. Individuals who did versus did not have PC encounters within 1-year before surgery were identified. A postoperative textbook outcome (TO) was defined as the absence of complications, no prolonged hospital stay, no readmission within 90 days, and no mortality.

Results

Among 63,177 patients, 50,974 (80.7%) had at least one established PC visit before surgery. Patients with established PC were more likely to achieve TO (odds ratio [OR], 1.14; 95% confidence interval [CI], 1.09–1.19) with lower odds for complications (OR, 0.85; 95% CI, 0.72–0.89), extended hospital stay (OR, 0.86; 95% CI, 0.81–0.94), 90-day readmission (OR, 0.94; 95% CI, 0.90–0.99), and 90-day mortality (OR, 0.87; 95% CI, 0.79–0.96). In addition, patients with established PC had a 4.1% decrease in index costs and a 5.2% decrease in 1-year costs. Notably, patients who had one to five visits with their PC in the year before surgery had improved odds of TO (OR, 1.21; 95% CI, 1.16–1.27), whereas individuals with more than 10 visits had lower odds of a postoperative TO (OR, 0.91; 95% CI, 0.84–0.98).

Conclusion

Most Medicare beneficiaries with digestive tract cancer had established PC within the year before their surgery. Established PC was associated with a higher probability of achieving ideal outcomes and lower costs. In contrast, patients with more than 10 PC appointments, which was likely a surrogate of overall comorbidity burden, experienced no improvement in postoperative outcomes.
Developing Trusted Collaborative Relationships between Healthcare Providers and Exercise Professionals
Authors: Bantham Amy , Young Jeff , Kampert Matthew
Published: August 2024

Apply It!

• Exercise professionals will see the importance of building a referral network and will take the outlined steps necessary to build one.

• Exercise professionals will recognize the importance of communication in building trusted collaborative relationships with healthcare providers and will put a plan in place to provide progress reports of outcomes back to providers to increase their buy-in to the referral system.