bluuebunny/crossref_metadata_2025 huggingface dataset:
Human Chorionic Gonadotropin Regulates the Smad Signaling Pathway
by Antagonizing TGF-β in Giant Cell Tumor of Bone
Authors: Xu Tangbing , Xu Shenglin , Ma Guangwen , Chang Jun , Zhang Chi , Zhou Ping , Wang Chao , Xu Pengfei , Yang Junjun , Hu Yong , Wu Yunfeng
Published: April 2023

Background:

Giant cell tumor of bone (GCTB) is a locally aggressive bone tumour
aggravated by stromal cell proliferation and metastasis.

Objective:

We investigated the mechanism of action of human chorionic gonadotropin (HCG) in
mediating GCTB proliferation and invasion.

Methods:

The expression of HCG was quantified using quantitative real-time PCR. After the primary
stromal cells were isolated and identified, the function of HCG in GCTB was estimated using
the cell counting kit-8, flow cytometry, scratch experiment, transwell assay, Western blot, and
immunofluorescence. Moreover, the mechanism of HCG was assessed through western blotting.

Results:

HCG expression was decreased in clinical tissue samples from patients with GCTB. We
validated that HCG repressed stromal cell proliferation, migration, invasion, autophagy, and epithelial-
mesenchymal transition (EMT) and promoted cell apoptosis in GCTB. We also verified
that HCG repressed the autophagy and EMT of stromal cells through the Smad signaling axis in
GCTB. HCG inhibited the transduction of the Smad signaling pathway by restraining the binding
of the TGF-β II receptor to ligand Activin A.

Conclusion:

HCG restrained the Smad signaling pathway by antagonizing TGF-β signaling in GCTB. HCG may serve as a useful patent to treat GCTB.
Advances in Peptide/Protein Structure Prediction Tools and their Relevance
for Structural Biology in the Last Decade
Authors: Rezende Samilla B. , Lima Lucas R. , Macedo Maria L. R. , Franco Octávio L. , Cardoso Marlon H.
Published: April 2023

Peptides and proteins are involved in several biological processes at a molecular level. In this
context, three-dimensional structure characterization and determination of peptides and proteins have
helped researchers unravel the chemical and biological role of these macromolecules. Over 50 years,
peptide and protein structures have been determined by experimental methods, including nuclear magnetic
resonance (NMR), X-ray crystallography, and cryo-electron microscopy (cryo-EM). Therefore, an
increasing number of atomic coordinates for peptides and proteins have been deposited in public databases,
thus assisting the development of computational tools for predicting unknown 3D structures. In
the last decade, a race for innovative methods has arisen in computational sciences, including more
complex biological activity and structure prediction algorithms. As a result, peptide/protein theoretical
models have achieved a new level of structure prediction accuracy compared with experimentally determined
structures. Machine learning and deep learning approaches, for instance, incorporate fundamental
aspects of peptide/protein geometry and include physical/biological knowledge about these macromolecules'
experimental structures to build more precise computational models. Additionally, computational
strategies have helped structural biology, including comparative, threading, and ab initio modeling
and, more recently, prediction tools based on machine learning and deep learning. Bearing this in
mind, here we provide a retrospective of protein and peptide structure prediction tools, highlighting
their advances and obstacles and how they have assisted researchers in answering crucial biological
questions.
Antimicrobial Efficacy of Various Nanoparticles on Addition to Orthodontic
Materials- A Systematic Review and Meta-Analysis
Authors: Kumari Deesha , Runa Soans Crystal , Shersha Shalin , Mansoor Rahila , Ravi M.S.
Published: April 2023

Aim:

The purpose of this study is to examine the evidence for the efficiency of nanoparticles
(NPs) incorporated into orthodontic materials (brackets, bonding agents, wires, acrylic resin, and elastics)
in order to enhance their antimicrobial properties.

Materials and Methods:

A comprehensive search strategy was conducted in electronic databases like
PubMed, Cochrane, and Google scholar, books, grey literature like unpublished literature, dissertations,
conference reports, etc. Finally, out of all the literature reviewed, a total of 30 articles met the inclusion
criteria and were included in the qualitative analysis. For the quantitative analysis, a total of 6 articles
were used.

Results:

Antimicrobial agents such as silver nanoparticles, Titanium dioxide, Silver platinum alloy, zinc
oxide and copper oxide, quaternary ammonium dimethacrylate (QADM), Hydroxyapatite crystals, and
silver, quaternary ammonium polyethyleneimine (QPEI) particles, silica, and titanium have been incorporated
in various orthodontic materials. The incorporation of these nanoparticles into orthodontic materials
led to a significant increase in the antibacterial capacity when compared to controls used in the various
studies.

Conclusion:

It can be concluded that the incorporation of nanoparticles into orthodontic materials
improves their antibacterial properties. Due to the heterogeneity observed across the studies reviewed,
further research with standardized study protocols in terms of the size, concentration, and techniques of
incorporation of different NPs into various orthodontic materials is pertinent.
From Abel Continuity Theorem to Paley-Wiener Theorem
Authors: Yu S. , Agarwal P. , Kanemitsu S.
Published: April 2023

In this note we reveal that the missing link among a few crucial results in
analysis, Abel continuity theorem, convergence theorem on (generalized) Dirichlet
series, Paley-Wiener theorem is the Laplace transform with Stieltjes integration. By
this discovery, the reason why the domains of Stoltz path and of convergence look
similar is made clear. Also as a natural intrinsic property of Stieltjes integral, the use
of partial summation in existing proofs is elucidated. Secondly, we shall reveal that a
basic part of the proof of Paley-Wiener theorem is a version of the Laplace transform.
Graphene-Based Nanomaterials and Their Sensing Application
Authors: Vaishnav Vikash Kumar , Prasad Khageshwar , Yadav Rashmi , Aharwar Amitabh , Nath Tiwary Bhupendra
Published: April 2023

Carbon-based materials (CBMs) like graphene, hybrid graphene compounds
(HCOGs), graphene nanoplatelets (GNPs), graphene oxide (GO), reduced graphene
oxide (RGO), and graphene quantum dots (GQDs), as well as their derivatives like
graphane, graphone, graphyne, graphdiyne, and fluorographene, are the direct
descendants of graphene-based nanomaterials (GBNs). GBNs are graphene derivatives
with single and multilayered graphene products. Their doped versions have marked
remarkable significance over the past decade in scientific fields for applications due to
their physical as well as their chemical properties. Graphene has emerged as a
promising application for sensing, gas separation, water purification, biotechnology,
disease diagnosis, bioengineering, and biomedicine. Graphene nanomaterials also play
an important role in surface engineering (bioconjugation), improving their performance
in vitro/in vivo stability and elevating the functionality of graphene-based
nanomaterials, which can enable single/multimodality image optical imaging, positron
emission tomography, magnetic resonance imaging and therapy photothermal therapy,
photodynamic therapy, and drug/ gene delivery in cancer. Graphene nanoparticles have
the natural fluorescence properties of graphene, which helps to bioimage cancer cells.
They are perspective drug carriers appropriate for their target selectivity, easy
chemosensitization, functionalization, and excellent drug-loading capacity. Iron-based
graphene composites are with other companionable materials of exploration to make
novel hybrid complexes with preferred uniqueness for biointerfacing.
Biosensors for the Diagnosis and Therapeutics of Cardiovascular Diseases
Authors: Shrivastav Avanish Kumar , Borah Dhitri , Mandal Sudeshna
Published: April 2023

Biomedical diagnostic research is becoming increasingly important in the
modern medical profession. Infectious disease inspection, initial detection, chronic
disease treatment, clinical services and well-being hunt down are the various
applications of biosensors. Advanced biosensor technology permits the identification of
the disease and the examination of the patient’s responses to medication. Sensor
technology is crucial for a broad range of low-cost and practicable developed medical
appliances. Biosensors offer many possibilities because they are unambiguous,
ascendable and capable of synthesizing procedures. Cardiovascular disease(CVD) is
now recognized as the leading cause of death. It is estimated that the number of people
dying from heart disease and stroke will approach 20 million by 2015. The risk event
of unexpected death associated with it can be minimized by recognizing the challenges
involved in its beginning, symptoms, and early detection. Therefore, this chapter aims
to provide an idea for the diagnosis and therapeutics of CVD. Biosensors, created to be
utilized as quick screening instruments to detect disease biomarkers early on and
classify the condition, are revolutionizing CVD diagnosis and prognosis. Biosensors
have become faster, more accurate, portable, and environmentally friendly diagnostic
equipment as a result of advances in interdisciplinary study domains.
Construction and Evaluation of Deep Neural Network-based Predictive Controller for Drug Preparation
Authors: Sobana Rani K. Sheela , Dattathreya  , Jain Shubhi , Sateesh Nayani , Lakshminarayana M. , Alexios Karras Dimitrios
Published: April 2023

The evaporator used in the pharmaceutical industry is for drug preparation.
The purpose of the evaporator in drug manufacturing is to extract the water content in
the material through the heating process. In this research, the SISO evaporator is taken,
which contains temperature as input and dry matter content as output. The
mathematical modelling of the drug preparation evaporator is done with the help of the
system identification method. Controlling and maintaining the temperature inside an
evaporator is a tedious process. In this regard, the Neural Network predictive controller
(NNPC) is designed and implemented for drug preparation. It helps to predict the
future performance of the evaporator and tune the control signal based on that. The
setpoint tracking challenge is given to the designed controller. For analysing the
performance of the controller, the error metrics, such as integral square error (ISE),
integral absolute error (IAE), integral time square error (ITSE), and integral time,
absolute error (ITAE), are employed. The time-domain specification, such as rise time,
settling time, and overshoot, is also used to better understand controller performance.
From the above two analyses, the conclusion is made that the predictive controller is
performing well in comparison with the conventional PID controller in the drug
preparation pharmaceutical industry. 
Machine Learning based Predictive Analysis and Algorithm for Analysis Severity of Breast Cancer
Authors: Radha B. , Sekhar Kolli Chandra , Prasanna Kumar K R , Rengaraju Perumalraja , Kamalesh S. , Mateen Buttar Ahmed
Published: April 2023

 Breast cancer is the 2nd frequent occurrence of cancer among women, after
skin cancer, according to the American Cancer Society. By using mammography, it is
possible to detect breast cancer before it has spread to other parts of the body. It
primarily affects females, though males can be affected as well. Early identification of
breast cancer improves survival chances significantly, however, the detection
procedure remains difficult in clinical studies. To solve this problem, a Machine
Learning (ML) algorithm is used to detect breast cancer in mammogram images. In this
study, 100 images from the mini-MIAS mammogram database were used, 50 of which
were malignant and 50 of which were benign breast cancer mammograms. Before
training the model, the sample image datasets are pre-processed using numerous
techniques. The required features are then extracted from the sample images using
Feature Extraction (FE) techniques, such as Daubechies (DB4) and HAAR. Finally, the
extracted features are fed into ML classifiers such as Linear Discriminant Analysis
(LDA), Support Vector Machine (SVM), and Random Forest (RF) to create a model.
Several performance metrics are used to evaluate FE and classification. According to
the results of the analysis, the HAAR FE with the RF model is the ideal combination,
with an accuracy level of 91%.
Texture Analysis-based Features Extraction & Classification of Lung Cancer Using Machine Learning
Authors: Swaroopa Korla , Chaitanya Kumar N. , Francis Britto Christopher , Malathi M. , Ganesan Karthika , Kumar Sachin
Published: April 2023

Lung cancer is a form of carcinoma that develops as a result of aberrant cell
growth or mutation in the lungs. Most of the time, this occurs due to daily exposure to
hazardous chemicals. However, this is not the only cause of lung cancer; additional
factors include smoking, indirect smoke exposure, family medical history, and so on.
Cancer cells, unlike normal cells, proliferate inexorably and cluster together to create
masses or tumors. The symptoms of this disease do not appear until cancer cells have
moved to other parts of the body and are interfering with the healthy functioning of
other organs. As a solution to this problem, Machine Learning (ML) algorithms are
used to diagnose lung cancer. The image datasets for this study were obtained from
Kaggle. The images are preprocessed using various approaches before being used to
train the image model. Texture-based Feature Extraction (FE) algorithms such as
Generalized Low-Rank Models (GLRM) and Gray-level co-occurrence matrix
(GLCM) are then used to extract the essential characteristics from the image dataset.
To develop a model, the collected features are given into ML classifiers like the
Support Vector Machine (SVM) and the k-nearest neighbor's algorithm (k-NN).
Association between hemoglobin levels and depression status in geriatric patients at Prof. DR. I. G. N. G. Ngoerah General Hospital
Authors: Kertiasih Ni Wayan , Nopriantha Made , Wahyuni Anak Ayu Sri , Diniari Ni Ketut Sri , Kuswardhani R A Tuty
Published: April 2023

Background: There is evidence of decreased hemoglobin levels as long as an ageing process in the elderly. Low hemoglobin level conditions not only influence physical status but also mental function in the elderly. Objective: to know the association between hemoglobin level and depression status in the elderly. Methods: This is an analytic cross-sectional study. Data were derived from medical records of elderly/Geriatric patients (age>60 years old) admitted to the Internal Medicine Department of Prof. Dr. I.G.N.G. Ngoerah General Hospital between January to July 2018. Anemia status was defined using WHO criteria and depression was defined using Geriatric Depression Scale (GDS) questionnaires. We use an independent t-test to know the association between a categorical and numeric variable with normal distribution. Statistically significant if p < 0.05. Results: A total of 102 patient was enrolled in this study consisting of 47,05% male and 52,94% female. The prevalence of depression in the elderly was 27,45% and there is no statistically different based on age and sex. There is an association between hemoglobin level and depression in the elderly (p=0,037; CI 0,76-3,14). Logistic regression analysis shows that age and hemoglobin level impact depression status in the elderly.
Extraction of Pandanus amaryllifiolus Roxb.: A review of methods and the influencing factors
Authors: Qomarudin Qomarudin
Published: April 2023

Pandanus amaryllifiolus Roxb is a tropical plant. Pandan leaves offer potential, especially for their function as a source of natural colors, aroma, and antioxidants. 2-Acetyls-1-pyrroline is the primary fragrance compound in pandan leaves. This scent is essential since it acts as the primary contribution of favorable substances which could be good for physical condition and provide flavor for food products. Its sweetness and flavorful taste are known as a natural origin of flavoring. Some previous studies have carried out standard extraction techniques such as maceration, percolation, reflux, and soxhlet in the extraction process of Pandan leaves. However, the process and results come out differently than the current techniques. The modern technique results in an effective extraction moment, and the solvent used is less than in conventional methods. Hence, this paper discussed several highly good methods, such as ultrasound-assisted extraction (UAE), microwave-assisted extraction (MAE), and supercritical fluid extraction (SFE). The extraction procedure is governed by some aspects that determine the extraction results. The proper extraction method selection also affects the extraction effectiveness. Therefore, enhancing the profitable value of pandan plants can lead to discovering a better-quality extraction technique.
Familia y escuela. Educación vinculante: caso de una institución en don Matías- Antioquia, Colombia
Authors: Rodríguez Bustamante Alexander
Published: April 2023

Introduction: this article presents a reflection on the family-school dyad, considering relevant and fundamental aspects for this relationship, such as family development as a precursor for school development and the cooperation process between the family and the school. Objective: for this, the experience of some of the teachers of the Rayuela Educational Institution located in the Municipality of Don Matías - Antioquia, who commented on the family-school link and its influence in natural scenarios where human beings develop, was taken into account. Reflection: a proposal was made about the types of families that are found in the different scenarios that occur in the reality and daily life of education and some characteristics that become evident when interacting with each of the actors. Conclusion: it was found that it is necessary to make a call to both family groups and schools about the urgency of involvement as a form of accompaniment, given that it is necessary to continue thinking about this dyadic exercise from their forms of relationship and daily interaction.
Disordered minerals and disease of soft tissue and bones in chronic kidney disease
Authors: Swanepoel Charles R
Published: April 2023

This article briefly reviews the mineral and bone disorder (MBD) found in patients with chronic kidney disease (CKD) and should provide a useful summary for trainees in nephrology and internal medicine. The storage of minerals is one of the principal roles of our bones, which are alive and are constantly being remodelled under the influence of vitamin D and parathyroid hormone (PTH), aided and abetted by calcium and phosphates. This occurs in a controlled fashion in healthy individuals. In patients with CKD, this control is lost and either an exaggerated, ineffectual remodelling takes place, resulting in the removal (in the case of high-turnover bone disease) or inadequate (in low-turnover bone disease) deposition of minerals. Vascular (and other soft tissue) calcification accompanies MBD, with phosphate and calcium playing major roles in the pathogenesis of the condition.
The Sixth Edition of the WHO laboratory manual for the examination and processing of human semen: is everything new a well-forgotten old?
Authors: Olefir Yu. V. , Vinogradov I. V. , Rodionov M. A. , Zhyvulko A. R. , Popov D. M. , Monakov D. M.
Published: April 2023

Despite many shortcomings, the semen analysis remains the leading method of male fertility assessment. For several decades, the WHO has been working on standardisation of the methodology for examining human ejaculate. In 2021, the sixth edition of WHO laboratory manual for the examination and processing of human semen was released, which proposed several concepts for performing and interpreting the results of a semen analysis. Many of these concepts are not new and have already been covered in previous tutorials. At the same time, the rejection of reference values and the transition to “decision limits” raises several questions that have not yet been answered.
Antimicrobial peptides for treatment of patients with herpes virus-associated chronic prostatitis
Authors: Kulchavenya E. V. , Shevchenko S. Yu. , Baranchukova A. A.
Published: April 2023

Introduction. Genital herpes is a chronic sexually transmitted infection characterised by recurrent self-limiting genital ulcers caused by herpes simplex virus type 1 (HSV-1) or type 2 (HSV-2) and can be associated with chronic prostatitis (CP).

Objective. To determine the efficacy of cytokines-antimicrobial peptides complex in therapy of patients with herpes virus-associated chronic prostatitis.

Materials & methods. The pilot, open, prospective, non-comparative study included 23 patients who were followed up for CP for a mean of 9.7 ± 4.2 years. All were diagnosed with abacterial CP / chronic pelvic pain syndrome (CPPS) with signs of inflammation and detection of HSV DNA in urethral swabs by polymerase chain reaction (PCR). Prescribed therapy: Tab. Valaciclovir 500 mg b.i.d. p.o. for 10 days, Tab. Ketoprofen 100 mg q.d. for 5 days, Supp. Superlymph 10 IU q.d. p.r. q.h.s. for 20 days. The results were evaluated at the end of therapy, 3 and 6 months after its completion.

Results. At the end of therapy, the leukocytes count in prostate secretion decreased by almost five times and remained stable throughout the entire follow-up period. The total symptom scale score at the end of therapy decreased from 22.96 ± 6.01 to 6.61 ± 3.71 points (p < 0.05). There was also a change in the perception of pain on a visual analog scale. If, before the start of treatment, 14 patients (60.9%) assessed the pain intensity as “severe” and only two (8.7%) had “weak” pain intensity, then after the end of therapy, none of the patients had severe pain, 21 (91.3%) patients noted "mild" pain and in 2 patients (8.7%) the intensity of pain was regarded as "average". Quality of life improved from baseline 8.23 ± 1.91 points to 2.43 ± 1.41 points immediately after completion of therapy (p < 0.05). Three months after therapy, patients assessed the quality of life as 2.43 ± 1.41 points, and six months later, as 2.81 ± 1.21 points. During the first three months, one patient experienced a HPV-relapse; one more — within the next three months. These patients underwent a second course according to a similar scheme. None of the patients reported significant side effects on any component of the therapeutic complex.

Conclusion. In abacterial CP/CPPS, a herpes infection should be identified. Being neurotropic, HSV can cause / exacerbate the pain characteristic of CP/CPPS. In case of persistent pain, HSV infection should be excluded. In the treatment of patients with herpes virus-associated abacterial CP, Supp. Superlymph showed good immediate and long-term results.
Evaluation of an Innovative Colon Capsule Endoscopy Service in Scotland From the Perspective of Patients: Mixed Methods Study
Authors: Bond Sarah , Kyfonidis Charalampos , Jamieson Matthew , Maguire Roma , McCann Lisa , Watson Angus , Brogan Michelle , Lennon Marilyn
Published: April 2023

Background

Colonoscopy is the gold standard for lower gastrointestinal diagnostics. The procedure is invasive, and its demand is high, resulting in long waiting times. Colon capsule endoscopy (CCE) is a procedure that uses a video capsule to investigate the colon, meaning that it can be carried out in a person’s own home. This type of “hospital-at-home” service could potentially reduce costs and waiting times, and increase patient satisfaction. Little is currently understood, however, about how CCE is actually experienced and accepted by patients.

Objective

The aim of this study was to capture and report patient experiences of the CCE technology (the capsule and associated belt and recorder) and of the new clinical pathway for the CCE service being rolled out as part of routine service in Scotland.

Methods

This was a mixed methods service evaluation of patient experiences of a real-world, deployed, managed service for CCE in Scotland. Two hundred and nine patients provided feedback via a survey about their experiences of the CCE service. Eighteen of these patients took part in a further telephone interview to capture more in-depth lived experiences to understand the barriers and opportunities for the further adoption and scaling up of the CCE service in a way that supports the patient experience and journey.

Results

Patients overall perceived the CCE service to be of significant value (eg, mentioning reduced travel times, reduced waiting times, and freedom to complete the procedure at home as perceived benefits). Our findings also highlighted the importance of clear and accessible information (eg, what to expect and how to undertake the bowel preparation) and the need for managing expectations of patients (eg, being clear about when results will be received and what happens if a further colonoscopy is required).

Conclusions

The findings led to recommendations for future implementations of managed CCE services in National Health Service (NHS) Scotland that could also apply more widely (United Kingdom and beyond) and at a greater scale (with more patients in more contexts). These include promoting CCE with, for, and among clinical teams to ensure adoption and success; capturing and understanding reasons why patients do and do not opt for CCE; providing clear information in a variety of appropriate ways to patients (eg, around the importance of bowel preparation instructions); improving the bowel preparation (this is not specific to CCE alone); providing flexible options for issuing and returning the kit (eg, dropping off at a pharmacy); and embedding formative evaluation within the service itself (eg, capturing patient-reported experiences via surveys in the information pack when the equipment is returned).
Study on the Implementation Path of Financial Support for Rural Revitalization
Authors: Tang Lingchao , Gao Shuang
Published: April 2023

Rural revitalization is an important strategy of the Chinese government to solve the new “three rural” problems, Carrying out rural vitalization work, It creates a whole set of financial needs. This paper analyzes the current situation and existing problems of China’s financial support for rural revitalization, And then put forward financial support for rural revitalization related suggestions.
Quantitative determination of fault slip magnitude: a review
Authors: Xu Shunshan , Nieto-Samaniego Angel Francisco , Xu Huilong , Li Wei , Nieto-Fuentes Ricardo
Published: April 2023

In geology, a fault is a rock fracture with perceptible relative displacement of the opposite sides of the fracture. Quantitatively obtaining the activity history of faults depends mainly on the estimation of fault slip and the study of markers, which can be used to understand and analyze the tectonic evolution of the faulted regions. Fault slip is calculated by restoring points that were originally adjacent before the deformation, those points are named piercing points. In this paper, we review some published methods to determine fault slip, using: (1) the offset of contours on structural contour maps; (2) offset on seismic reflection sections; (3) a known slip vector (fault striae) and one marker; (4) two known markers. Cases (3) and (4) are commonly applied to field work and geological maps.
Experimental Analysis of Polymer Insertion in Bricks Formation Under Sustainable Development Approach
Authors: Mahajan Rohit M , Mankar Atharva D , Kute Amol K , Awari Vivek R
Published: April 2023

Abstract: The plastic waste is the hazardous problem in today’s world. This is most dangerous problem in front of society. The most hazardous type of wastes are HDPE and PTE and the plastic below 50 micron is also causing a serious problem like plastics wastes, non degradable, environmental pollution. These plastic mixed in the soil, it directly effects on fertility of the soil. Nowadays, the large amount of plastic is deposited into sea. This plastic wastes gives hazardous effect on the aquatic life and quality of seawater also polluted by this plastic. By recycling and reuse we try to find efficient way to solve this problem of plastic waste. So by various test trials in the project we added this plastic wastes into the bricks and create the bricks by using plastic wastes. It is most economical solution present in the construction industry and it is also economical and environment friendly solution of the plastic wastes.
Design and Implementation of Haptic Prosthetic Hand for Realization of Intuitive Operation
Authors: Kavitha R J , Nisarga H S , Gwoda Padmaraj N , Sandhya K Sai , Tharun M
Published: April 2023

Abstract: This project presents the design and implementation of a microcontroller-based voice activated wireless automation and hand movement system replicating using flex sensor system. As speech is the preferred mode of communication for human beings, this project intends to make the voice-oriented command for controlling the hand movements. The voice command is user independent. The system comprises of transmitting section and receiving section. Initially, the voice command is stored in the data base with the help of the function keys. Later the input voice commands are transmitted to through wireless device. The voice received is processed in the voice recognition system where the feature of the voice command is extracted and matched with the existing sample in the database. The module recognizes the voice and sends control messages to the microcontroller. This project also focuses on replicating the movements of the human hand using a plastic 3D printed hand simulation (hand frame). The flex sensors and servo motors work in co-ordination with ARDUINO to achieve this. The sensor sends the value to the ARDUINO, the ARDUINO processes the data and sends it to the servo motors. Based on the values provided the motor moves and thus the movement of the prosthetic hand is observed-replicating the motion of the hand.The functionality of the proposed project is based on myo-electric arm
Investigation of Fin Thickness on Heat Transfer Characteristics of Engine
Authors: Taur Ankita , Shinde Dhanashri , Taur Avinash , Deore Prashant , Satpute Jitendra
Published: April 2023

Abstract: Fins are one of the important key cooling elements. The main purpose of pin fins is to increase the rate of heat transfer to the surroundings by improving convection. The transferred heat will exist in the form of conduction, convection and radiation. If the temperature coefficient of heat transfer increases, the cooling rate will also increase. The main objective of our project is to increase the rate of heat transfer in different types of fins with different shapes.3D models were designed in Catia and tested in Ansys. Use the developed fins in various applications.
Automatic Reduction of THD for Non-Linear Load by Using Microcontroller
Authors: Paunikar Rajat , Gaygowad, Suraj , Ghushey Amit , Bhonde Krishnakant , Gedam Shreyash , Padole Pranit , Honshette Nikhil , Halmare Abhay
Published: April 2023

Abstract: In a perfect world, the term harmonics used to describe power quality would refer to how pure the voltage and current waveforms are when they take the shape of sinusoidal. Power quality is veritably important to commercial and industrial power system designs. ideally, the electrical supply should be a perfect sinusoidal waveform without any kind of distortion or disruption. If the current or voltage waveforms are distorted from its ideal form it'll be nominated as harmonic distortion. This harmonic distortion could affect because of numerous reasons.
Adaptive Weed Detection and Removal Using Cutter and Pesticide Spraying AGBOT
Authors: S Manasa , G Tanushree , S Suhas , C Sumanth C. , M Sukanya
Published: April 2023

Abstract: Agriculture is one amongst the world's oldest sources of human nourishment. Weeds are a problem as they compete with desirable crops and use up water, nutrients, and space. Development of a successful weed removal system involves correct identification of the unwanted vegetation. The working of the robot is done on the basis of Arduino Uno, where every motion is controlled by the program which is fed into the Arduino. The main purpose of the robot is to identify the weed and remove the weed using cutter and spray the pesticide, using pesticide sprayer only where weeds were present.
Aproximación a la estructura económica de la Región del Bío-Bío en base a aplicaciones insumos producto, para el año 2006 y base 2003
Authors: Pino Arriagada Osvaldo , Parra Márquez Juan Carlos
Published: April 2023

En este artículo, a partir de una Matriz Insumo- Producto Regional (MIPR) actualizada y la utilización del enfoques de análisis estructural de Rasmussen (1958), se realiza un análisis comparativo de los índices de Poder de Dispersión y Sensibilidad de Dispersión, conceptos que permiten cuantificar la naturaleza de los eslabonamientos sectoriales, hacia delante y hacia atrás (forward and backward linkages) para el periodo 1998-2006.Se describe la metodología y método RAS de actualización de las respectivas tablas input-ouput (40x40 sectores); A partir de la nueva matriz inversa de la VIII Región del Bío Bío de 40*40 sectores se procede a presentar y estimar los conocidos índices de poder y de sensibilidad de dispersión.Posteriormente se caracterizan estas actividades en sectores claves, estratégicos, impulsores, islas. La presentación de los resultados se realiza sobre la base de un conjunto de tablas; que persiguen entregar una visión de los eslabonamientos intersectoriales de las actividades gravitatorias de la economía regional. AbstractIn this paper, based on an updated regional input-output matrix (MIPR) and Rasmussen’s structural analysis approach, we present a comparative analysis for the power of dispersion and sensitivity of dispersion indices, which enable us to quantify the nature of the backward and forward linkages for the period 1998-2006.Using the RAS methodology and starting from a new inverse matrix for the Bio Bio region, which considers 40x40 productive sectors, we present and estimate the power of dispersion and sensitivity of dispersion indices.Finally, we classify the above economic sectors as key, strategic, driver, or island. The results are shown in several tables, which pretend to present the productive linkages between the main economic activities of the regional economy.
Análisis y evaluación crítica del rol desempeñado por la organización internacional del trabajo (OIT) en desarrollar y asegurar principios y derechos fundamentales en el trabajo
Authors: López Bohle Sergio , Ugarte Gómez Sebastián
Published: April 2023

Este artículo analiza el rol y misión de la OIT en promover los principios fundamentales en el trabajo (PFT) y monitorear su cumplimiento. También hace una evaluación crítica de la efectividad de los métodos empleados por la ILO para asegurar los PFT, en un complejo contexto de diferentes grados de desarrollo social y económico, ideologías políticas, así como tener que lidiar en algunas ocasiones con propósitos divergentes de sus actores sociales (empleadores, trabajadores y gobiernos). El artículo discute los principales debates y problemas enfrentados por la OIT al momento de interactuar con la diversa gama de Estados miembros. Finalmente, son propuestas algunas observaciones con el objetivo de mejorar la aplicación de los PFT en vista de los nuevos desafíos sociales y económicos del mundo actual. AbstractThis paper analyses the role and mission of the ILO in promoting core labour standards (CLS) and monitoring its compliance. It also makes a critical assessment to the effectiveness of the methods employed by the ILO to secure the CLS, in a complex context of different degrees of social and economic development, political ideologies, as well as dealing in some occasions with divergent purposes of its social actors (employers, workers and governments). The article discusses the main debates and issues faced by the ILO when interacting with its diverse range of member States. Finally, some fi nal remarks are proposed with the objective to improve the application of the CLS to the new social and economic challenges of today’s world.
El rol moderador de la flexibilidad del horario de trabajo en la relación del enriquecimiento trabajo familia y la satisfacción docente
Authors: Jijena-Michel Robert Daniel , Jijena Michel Carlos Eduardo
Published: April 2023

El propósito de esta investigación es analizar la relación entre el enriquecimiento trabajofamilia y la satisfacción laboral docente; como también el efecto moderador de la flexibilidad del horario de trabajo en dicha relación. El enriquecimiento trabajo-familia se refiere a la forma en que el trabajo y la familia se benefician entre sí, y es bidireccional: trabajo-familia y familia-trabajo. Se recogió información primaria por medio de cuestionarios aplicados a docentes universitarios de la Facultad de Ciencias Económicas y Financieras de la Universidad Autónoma Juan Misael Saracho (Tarija, Bolivia). Los resultados reflejan que el enriquecimiento trabajo-familia influye de manera positiva en la satisfacción laboral, mientras que el enriquecimiento familia-trabajo no. Además, la flexibilidad del horario presenta un efecto moderador significativo sobre la relación enriquecimiento trabajo-familia y satisfacción. Es más, dicho efecto moderador provoca que el enriquecimiento familia-trabajo se vuelva significativo para la satisfacción. Estos hallazgos se convierten en insumos útiles para el diseño e implementación de políticas en conciliación trabajo-vida y prácticas de trabajo flexible, con el fin de mejorar la satisfacción del profesorado y consecuentemente, su compromiso organizacional. AbstractThis paper aims to analyze the relationship between work-family enrichment and faculty job satisfaction, and also the moderating effect of job schedule flexibility on the stated relation. Workfamily enrichment refers to how work and family benefit each other, and it’s bidirectional: workfamily and family-work. Data were collected through surveys applied to university professors from Economics and Finance Faculty of Juan Misael Saracho Autonomous University (Tarija, Bolivia). Results show that work-family enrichment is positively related with job satisfaction, while family-work enrichment is not. Furthermore, job schedule flexibility has a moderating effect on the relationship between work-family enrichment and job satisfaction. Moreover, the moderating effect causes that family-work enrichment becomes significant for satisfaction. These findings could be helpful inputs to design and implement policies concerning to work-family balance and work flexible practices, in order to improve faculty satisfaction and consequently, their organizational commitment.
La distribución del ingreso en Chile: La urgencia de una propuesta clara, sencilla y eficaz
Authors: Ortiz Soto Humberto
Published: April 2023

Durante los años noventa y hasta la crisis asiática, Chile fue capaz de crecer a tasas altas, presentando notables avances en, reducción del desempleo, aumentos reales de salarios e ingresos, control de la inflación, etc. A pesar de este dinamismo, la distribución del ingreso se mantuvo inalterada, manteniéndose su elevada concentración. Tras la crisis asiática y la recesión de 1999, la economía chilena ha retomado una senda de crecimiento, aunque a tasas moderadas en relación a las que prevalecieron durante los noventa.
Impactos y consecuencias en el sector azucarero en Colombia a partir del TLC con la Unión Europea
Authors: Espinosa Acuña Óscar Andrés , Vaca González Paola Andrea
Published: April 2023

La presente investigación tiene por finalidad analizar el impacto en Colombia del tratado de libre comercio con la Unión Europea, respecto a la dinámica del sector azucarero en Colombia, como producto de consumo interno y de exportación. Se analizan los aspectos de producción, competitividad y posibles cambios estructurales que se puedan presentar sobre este sector frente a los nuevos retos contemplados en el mercado mundial. Para ello se estima un sistema de ecuación de oferta y un modelo VAR-X, utilizando la información mensual de enero de 2000 a febrero de 2012, reportada por Asocaña y la FAO. Se concluye que el sector se encuentra apto para responder ante el acuerdo comercial, y representaría beneficios económicos importantes para la nación. AbstractThis research aims to analyze the impact on Colombia of the Free Trade Agreement with the European Union, regarding the dynamics of the sugar sector in Colombia, both as a product of domestic consumption and export. It discusses the aspects of production, competitiveness and possible structural changes that may occur on this sector regarding the new challenges set out in the world market. To do this, it is estimated a supply equation system and a model VAR-X, using monthly data from January 2000 to February 2012, reported by Asocaña and FAO. It is concluded that industry is able to respond to the trade agreement, and represent significant economic benefits for the nation.
La seguridad social: Algunos aspectos de su crisis actual
Authors: Ortiz Soto Humberto
Published: April 2023

La antigüedad, universalidad y generosidad del sistema de seguridad social público, así como los cambios en la estructura demográfica y en el mercado de trabajo (incremento del desempleo y el subempleo), han generaron fuertes déficits y aportes cada vez más crecientes por parte de los Estados de la Europa Occidental. Esto ha provocado en los últimos años un intenso debate, respecto al grado de intervención del Estado en este campo, más conocido como "la crisis actual del Estado de Bienestar", y el conflicto entre argumentos ha surgido con singular fuerza.
¿Retorno de la educación o premio al título universitario?
Authors: Jorquera Neira Fabián , Mardones Poblete Cristian
Published: April 2023

El “retorno de la educación” en Chile ha sido largamente analizado en diversos estudios de corte transversal, cohortes, y modelo en diferencias. Sin embargo, este es el primer estudio que utiliza la encuesta Panel Casen 1996-2001-2006, lo cual es importante como nueva evidencia ya que los datos de panel mejoran la capacidad de estimar la tasa de retorno (Heckman et al., 2006). Los resultados obtenidos son sensibles a métodos de estimación alternativos como mínimos cuadrados ordinarios, panel de efectos fijos y panel de efectos aleatorios. Se concluye con estimadores consistentes que en este país existe solamente un premio al título universitario más que un “retorno a la educación”.
Conmutación interregional, una mirada desde la VIII Región del Bío-Bío ( NENE año 2012)
Authors: Pino A. Osvaldo , Concha M. Gary
Published: April 2023

El estudio realiza un procesamiento y análisis de la información de las principales dimensiones y características de la movilidad residencia-trabajo contenida en la NENE de 2012 para la Región del Biobío (VIII). Mediante un modelo de autonomía de oferta y demanda, en un enfoque sincrónico, se presenta el estado de la variable conmutación desde la perspectiva de género, la componente etaria y otras características socio-profesionales (CIIU - CIOU). Se demuestra que la región se presenta como oferente neto de conmutantes masculinos y se cuantifica el impacto económico de este proceso. AbstractThe study takes a processing and data analysis of the main dimensions and characteristics of mobility residence-work contained in the NENE 2012 to the Biobío Region (VIII). Using a model of autonomy of supply and demand in a synchronous approach, the state of the commutation variable from the perspective of gender, age component and other socio-professional (CIIU-CIOU) is presented. We show that the region is presented as net supplier of male commuters and economic impact of this process is quantified.
Hipótesis de futuro en el desarrollo de la Región del Bío-Bío
Authors: Tohá González Jaime
Published: April 2023

Al compartir con ustedes algunas vivencias sobre el presente y el futuro de nuestra región, permítanme exponer algunas hipótesis que más adelante espero ir entrelazando en esta exposición.1.- Estamos llegando al final de un ciclo del modelo de desarrollo económico y social.2.- Tenemos un serio problema de capital humano y sobre todo de capital social para enfrentar los desafíos del nuevo ciclo.3.- Estamos ad portas de un profundo proceso de descentralización, frente al cual esta Región tiene una responsabilidad evidente.
Diferencias territoriales en el retorno a la educación en Chile: Evidencia para las regiones del Biobío y Metropolitana
Authors: Candia Genaro E. , Acuña Andrés A.
Published: April 2023

El presente trabajo aborda las diferencias en el retorno de la educación entre dos de las regiones con mayor presencia de instituciones de educación superior en Chile, Biobío y Metropolitana. Diversas variantes de la ecuación de Mincer son estimadas mediante el método Heckit empleando datos provenientes de la encuesta CASEN de los años 2000 y 2011. Los resultados corroboran la existencia de diferencias territoriales en desmedro del Biobío, las que se observan en el retorno a la educación, a la experiencia y en el efecto título. Finalmente, la evidencia constata la presencia de discriminación laboral por género en ambas regiones y por etnia sólo en la región Metropolitana.
Análisis comparativo del proceso de dirección estratégica entre los servicios de salud de la Región del Biobío
Authors: Barra Salazar Ana M. , Contreras Oliva Luis A.
Published: April 2023

La investigación realizada, contempla estructuralmente la revisión del proceso de Dirección Estratégica de los cinco Servicios de Salud de la Octava Región. Este estudio fue realizado a partir de una revisión bibliográfi ca que repasa los conceptos incluidos en el este estudio, siendo claves los de Análisis Estratégico, Planifi cación Estratégica, Estrategias, Control, Directrices. Posterior a esta revisión se analizará la información relevante de cada entidad estudiada, con el propósito de concluir como el proceso de Dirección Estratégica fue llevado por cada entidad. Todo este análisis es realizado para concluir y recomendar futuras líneas de acción para cada Servicio de Salud, al momento de defi nir sus Estrategias y como estas son; generadas, defi nidas y controladas para la consecución de los objetivos estratégicos.
Nuevas generaciones en las empresas: Algunas claves para su gestión
Authors: Navós Oscar
Published: April 2023

Con el paso de los años – y en un contexto de globalización y por tanto de cambios constantes – las nuevas generaciones de trabajadores refl ejan nuevas características, deseos y perspectivas laborales que plantean desafíos de permanencia y satisfacción de sus empleados a las empresas.El presente artículo tiene como objetivo general caracterizar a la generación “Y” y su inserción en el mercado laboral. A su vez persigue establecer algunas propuestas de liderazgo que faciliten la inserción y retención laboral de esta generación en el mercado laboral actual.
Determinantes de buenas prácticas gerenciales para Colombia en el año 2013. Una aproximación analítica desde modelos LOGIT
Authors: Hernández Umaña Ph.D. Iván Darío , Espinosa Acuña M.Sc. Oscar Andrés , Ramírez Rozo B.A. Hernán Felipe
Published: April 2023

Este trabajo investiga sobre algunos de los determinantes de las buenas prácticas gerenciales en Colombia. A partir de una encuesta a empresarios colombianos realizada por la London School of Economics en el año 2013, se construye un indicador de calidad de gerencia y mediante el uso de modelos de regresión logística se determinan las variables que más asociación presentan con una buena práctica gerencial. Dentro de las conclusiones principales se tiene que tanto los factores internos como externos a la empresa afectan considerablemente el gobierno corporativo, por lo que se propone enfocar este tipo de análisis desde un marco analítico como el propuesto por Bénabou y Tirole (2003), donde se puede considerar al tema gerencial, como un problema de motivaciones intrínsecas y de incentivos explícitos para las habilidades empresariales.