bluuebunny/crossref_metadata_2025 huggingface dataset:
CARNOSINE-LOADED ORAL NIOSOMES AMELIORATE HIGH-FRUCTOSE-INDUCED METABOLIC SYNDROME IN RATS VIA MODULATION OF SIRT1, A METABOLIC MASTER SWITCH
Authors: Ahmed Amany I , Nasr Nada Y. , Said Mahmoud A. , Alattar Reham H. , El-Dawy Khalifa
Published: February 2023

Metabolic syndrome is a crucial health challenge, and the available therapeutic agents are still not effective. Carnosine, a cytoplasmic dipeptide, is a potent anti-glycation, anti-oxidant, anti-inflammatory and chelating agent. However, whether carnosine would be assumed as a potential hypoglycemic agent or not, no decisive report with detailed mechanisms is found yet. As such, we suggest the carnosine-loaded in niosomes as a prospective solution to bypass its unwanted fast degradation by carnosinase which is considered as a major obstacle with the clinical application of carnosine as an oral drug therapy. Toward this, the purpose of our study is to assess the profits of oral administration of carnosine, and carnosine-loaded niosome in HFD-induced metabolic syndrome rats and to inspect some of the involved mechanisms. Initially, carnosine-loaded niosomes were prepared and characterized. Then, metabolic syndrome was provoked by 60% fructose diet in male Sprague Dawley rats where carnosine and carnosine-loaded niosomes were orally administered at doses 50 mg/kg and 25 mg/kg, respectively. In addition, biochemical and molecular studies were performed to clarify the possible mechanisms of action. Data showed that the consumption of 60% fructose diet displayed a tremendous increment in body weight, body mass index as well as a significant elevation in levels of serum glucose, insulin, TAG, TC, LDL-c, VLDL-c and FFA. Also, it showed a significant reduction in levels of serum HDL-c. Furthermore, HFD provoked up-regulation of SREBP-1c and FAS mRNA levels in adipose tissue. Also, it induced down-regulation of SIRT1, GLUT-4 mRNA levels in adipose tissue. We found that oral administration of either carnosine or carnosine-loaded niosome effectively reversed HFD-mediated alterations via SIRT1 activation. Overall, oral delivery of carnosine-loaded niosome had a better efficacy than oral carnosine, attenuating HFD-mediated alterations. Carnosine nano-formulation is a new excellent candidates for metabolic syndrome management and needs further exploration of its mechanisms.
MONITORING THE INFLAMMATORY PROCESS OF FELINE LOWER URINARY TRACT DISEASE
Authors: Mustafa Basma , Gouda Heba , Shehta Ahmed , Shety Tarek
Published: February 2023

This study aimed to compare the hemato-biochemical parameters in cats suffered from FLUTD with those of healthy cats, and to evaluate the inflammatory process by measuring serum amyloid A, alpha-1-Acid glycoprotein, and plasma fibrinogen concentrations. Cats frequently suffer from feline lower urinary tract disease (FLUTD), which causes acute renal failure, electrolyte buildup, and acid-base imbalance. Acute-phase proteins can be used to monitor the inflammatory processes of feline lower urinary tract disease.The present study included thirty cats of both sexes, nine cats defined as clinically healthy cats and 21 cats with signs of idiopathic cystitis and/ or urethral obstruction for up to 24 hours were defined as cat with FLUTD group. Blood samples were collected from cephalic vein for hematological, biochemical assays and the measurement of acute-phase protein concentrations, including SAA, AGP, and fibrinogen. Serum SAA and AGP were measured using commercial ELISA kits.In cats with FLUTD, the total white blood cell count, neutrophils, and platelets count increased significantly, as did the mean values of hematological and biochemical indices. However, there was a significant decrease in the mean value of red blood cells, hemoglobin, and PCV. Blood urea nitrogen, creatinine, total proteins, albumin, potassium, and phosphorus levels all increased significantly, while sodium and chloride levels decreased significantly. When compared to clinically healthy cats, plasma fibrinogen, serum alpha-1- acid glycoprotein, and serum amyloid A levels were significantly higher in cats with FLUTD. There was a significant positive correlation between the concentrations of acute phase proteins biomarkers (SAA, AGP, and fibrinogen) and blood urea nitrogen and creatinine. It is concluded that, in cats with FLUTD, serum amyloid A, AGP, and fibrinogen could be employed as an indicator of inflammatory processes.
ANTIOXIDANT ACTIVITY AND INHIBITORY EFFECT OF 2,4,4'-TRIHYDROXYCHALCONE ON DIGESTIVE ENZYMES RELATED TO OBESITY
Authors: Alsufiani Hadeil , Aldhaheri Ghaynat A. , Omar Ulfat M. , Bahdilah Taraji M. , Mansouri Rasha A.
Published: February 2023

The aim of this study was to investigate the antioxidant activity and inhibitory effect of 2,4,4'-trihydroxychalcone on digestive enzymes related to obesity, including sucrase, α-amylase, and lipase. The in vitro antioxidant activities of three concentrations of 2,4,4'-trihydroxychalcone (100, 300, and 500 µg/ml) were determined using 2,2-diphenyl-1-picrylhydrazyl radical scavenging, reducing power, and ferrous ion chelating assays. Moreover, in vitro inhibition of lipase, α-amylase, and sucrase enzyme activities by 2,4,4'-trihydroxychalcone was determined using a specific assay for each enzyme. 2,4,4'-Trihydroxychalcone has been shown to have antioxidant properties and inhibits sucrase, α-amylase and lipase activities. These findings suggest that 2,4,4′-trihydroxychalcone demonstrated an antioxidant activity and can effectively inhibit the key enzymes related to obesity.
PREVALENCE, PHENOTYPIC-GENOTYPIC RESISTANCE AND BIOFILM FORMATION OF Staphylococcus aureus IN CHICKEN MEAT WITH REFERENCE TO ITS PUBLIC HEALTH HAZARD
Authors: Morshdy Alaa Eldin M. A. , Tharwat Ahmed E. , Merwad Abdallah M. A. , Abdallah Nada A. M. , Saber Taisir
Published: February 2023

The purpose of this study was to determine the prevalence, antimicrobial resistance in S. aureus and presence of enterotoxigenic as well as biofilm-forming genes in S. aureus bacteria isolated from broiler meat from traditional shops and supermarkets in Sharkia, Egypt. For this determination, two hundred fresh raw chicken meat cotton swabs were collected from the breast and thighs (100 each). S. aureus was highlighted through a coagulase test, and then phenotypic and genotypic characterizations were studied. Uniplex PCR was used to identify the occurrence of enterotoxin genes in the selected isolates. Finally, they were subjected to a biofilm formation test using 96-well flat bottom polystyrene microtiter plates; besides, biofilm-forming genes were investigated. Nineteen isolates out of the 200 samples tested positive for S. aureus (9.5 percent), No Vancomycin resistance strains were obtained, nor did any ciprofloxacin isolates for S. aureus while, all isolates were 100 % resistant for streptomycin, amoxicillin- clavulanic acid and sulfamethoxazole-trimethoprim S. aureus isolates were found resistant to at least one antibiotic. The multiple antibiotic resistance (MAR) index of S. aureus isolates was ranged from 0.3 to 0.7 with an average of 0.4. In The mecicillin resistant S.aureus (MRSA) strains carried mecA gene with a percentage of 5%, while the blaZ gene was distributed with a percentage of 5.5%, 11/200). The obtained isolates gave 60% strong biofilm formation and 40% were non-formers, with nil results for moderate or weak production isolates. The icaA gene was 100%, in comparison to icaD which was zero. It should be noted that strong biofilm former strains were only 100% positive for sea and seb. This study pointed out the higher prevalence of MDR isolates of S. aureus isolates in chicken meat due to inadequate handling and insufficient sanitary equipment and post microbial contamination. This finding highlighted the importance of broiler meat as a reservoir for antimicrobial-resistant strains of S. aureus and biofilm-forming of Staphylococcus aureus.
PREVALENCE OF Staphylococcus aureus AND Salmonella SPECIES IN CHICKEN MEAT PRODUCTS RETAILED IN EGYPT
Authors: Morshdy Alaa Eldin M. A. , Mahmoud Abdallah Fikry A. , Khalifa Sahar M. , El-Dien Waiel M. Salah , Darwish Wageh Sobhy , El Bayomi Rasha
Published: February 2023

Chicken meat products represent an important source of animal derived proteins, vitamins, and minerals. However, chicken meat products might act as potential sources of human exposure to foodborne pathogens such as Staphylococcus aureus (S. aureus) and Salmonella species. The objectives of the present study were first to investigate the prevalence rates of S. aureus and Salmonella species in the retailed chicken meat products at Zagazig city, Egypt. Second, serological identification of the isolated bacteria was followed. Third, screening of S. aureus enterotoxin coding genes (sea seb, and sed) as well as Salmonella virulence associated genes including invA, Salmonella hyper-invasive locus (hilA), and Salmonella enterotoxin (stn) was done using PCR. The obtained results revealed isolation of S. aureus from the examined chicken meat products at 22%, and Salmonella spp., at 6.66%. Where S. aureus was isolated at 33.33%, 36.66%, 13.33%, 6.66%, and 20% from the examined chicken burger, fillet, luncheon, nuggets, and panne, respectively. Salmonella spp. could be isolated only from chicken burger and fillet at 10%, and 23.33%, respectively. The recovered S. aureus isolates harbored enterotoxin coding genes (sea, and seb). Likely the recovered Salmonella spp. isolates harbored virulence associated genes such as invA, hilA, and stn. Moreover, antimicrobial sensitivity testing of the recovered isolates showed multidrug resistance profiling. In conclusion, chicken meat products retailed in Egypt might be potential sources for the spread of multidrug resistant S. aureus and Salmonella spp. Therefore, strict hygienic measures should be adopted during manufacturing of such meat products.
AMELIORATIVE EFFECTS OF VITAMIN E AND SELENIUM ON BLEOMYCIN-INDUCED MALE INFERTILITY
Authors: Abd El-Fadil Ibrahim Hosny , Shalaby Shimaa I. , Hebishy Rasha Mahmoud M. A. , Abdelfattah-Hassan Ahmed , Abdel Ghani Eman Mohamed Abdel Mohsen
Published: February 2023

Bleomycin (BL) is a well-known anticarcinogenic chemotherapy that is used for the remedy of numerous varieties of most cancers. However, the use of BL became connected to the prevalence of several unfavorable results together with skin and lung fibrosis and testicular cancer. Dietary micronutrients such as vitamin E, and selenium (Se) are gambling critical roles in maintaining the health of human and animals and preserving the cell redox status homeostasis through their antioxidant roles. The objectives of the current investigation had been to investigate BL-induced male infertility in Albino rats. The protecting effects of either vitamin E, or Se towards such detrimental outcomes had been additionally examined. Moreover, the potential mechanisms behind such adverse effects had been evaluated. The obtained results indicated significant reduction in the testosterone, FSH, and LH levels in the BL-treated group. Likely, sperm characteristics as sperm count and motility had been significantly reduced in BL-treated group. Such changes have been associated with a significant reduction within the antioxidant enzymes including CAT, GPx, SOD, and MDA. Interestingly, co-exposure of experimental rats to either BL with vitamin E, or Se had notably parameters relatively close to the normal levels suggesting the ameliorative effects of vitamin E and Se towards BL-induced male infertility.
A Mobile System for Collecting a Digital Trace for the Task of Accounting and Analyzing Horizontal Learning in the Learning Process without using a Cellular Connection
Authors: Alimbekov Robert Rinatovich , Khasyanov Airat Faridovich
Published: February 2023

Today, users of mobile applications in different areas leave a huge amount of digital footprint. The main types of digital footprints are text, photos, videos, audio, and current location. To assist the teacher in horizontal learning, a mobile application that collects all of the above types of digital footprint was developed as well as web application that analyzes it.
The Use of Information Technologies and Modern Means of Digitalization in the Organization and Conduct of VI All-Russian Conference “Information Technologies for Earth Sciences and Digitalization in Geology and Mining Industry. ITES-2022”
Authors: Naumova Vera Viktorovna , Eremenko Vitaliy Sergeevich , Eremenko Alexander Sergeevich
Published: February 2023

The article describes the use of information technologies and modern means of digitalization in organizing and holding a Conference on IT in Earth Sciences. Modern aspects of visualization are also described in the reports of the Conference participants.
microRNA: Sebuah panduan pemula untuk klinisi dan peneliti
Authors: Sanjaya Ardo
Published: February 2023

microRNA (miRNA) adalah RNA pendek (sekitar 22 nukleotida) yang tidak mengkode pembentukan protein. Tetapi, walaupun RNA ini tidak mengkode protein, mereka mengatur banyak fungsi penting dalam tubuh manusia. miRNA pertama ditemukan pada tahun 1993 dan sekarang telah ditemukan mempengaruhi hampir semua penyakit manusia seperti diabetes dan kanker. Tidak seperti mRNA konvensional, miRNA menjalani jalur pemrosesan terpisah dengan beberapa langkah di dalam nukleus dan sitoplasma. Proses ini juga dikontrol dengan ketat di banyak titik, menciptakan jalur regulasi yang sangat kompleks. Gangguan jalur ini dapat menyebabkan fenotipe penyakit seperti yang ditunjukkan oleh banyak pola ekspresi miRNA yang terkait dengan keadaan penyakit. Namun, perkembangan mikroRNA masih relatif baru, dan ada banyak hal yang masih belum kita ketahui. Oleh karena itu, artikel ini bertujuan untuk memberikan pendahuluan mengenai miRNA mulai dari sejarahnya hingga perkembangan terbaru bagi para dokter dan peneliti. Suatu hari nanti, terapi berbasis RNA mungkin menjadi hal yang umum sehingga peneliti dan dokter harus terbiasa dengan subjek yang berkembang pesat ini.
THE INHIBITION EFFECT OF MORINGA (Moringa oleifera L.) LEAVES AND RED GINGER RHIZOME (Zingiber officinale Rosc.) PT. "P" ETHANOL EXTRACT ON ENHANCEMENT SERUM CREATININE LEVELS OF MALE WISTAR RATS DYSLIPIDEMIA MODEL
Authors: Wijaya Juliana , S Martioso Penny , Puradisastra Sugiarto
Published: February 2023

The elevation of serum creatinine levels can be used as a biomarker of decreased kidney function. Dyslipidaemia is one of the causes of decreased kidney function. Long-term consuming statins has been shown to lower cholesterol levels but can increase serum creatinine levels. Moringa leaves (Moringa oleifera L.) and red ginger rhizomes (Zingiber officinale Rosc.) have antioxidant effects. The aim of this study was to determine the inhibitory effect on increasing serum creatinine levels of the concoction Moringa Leaves and Red Ginger Rhizome extract (CML-RGRE). This True Laboratory Experimental Study with Completely Randomized Design was conducted on 30 male Wistar rat dyslipidemia models, induced by high-fat feeding (HFF) and Propylthiouracil (PTU) 0.01% for 21 days. The subjects were divided into 6 groups (n=5), during treatment all subjects were still given HFD and PTU. Groups I, II, III were treated with CML-RGRE dose 135, 202.5, 270 mg/kg BW, IV as dyslipidemia control no added any treatment, comparison control groups V treated with 1.8 mg/kg BW and VI with fenofibrate 5.4 mg/kg BW. Serum creatinine levels (mg/dL) of all subjects were measured after 7 days acclimatization, after creating dyslipidemia models, and after 21 days treatment by using a spectrophotometer with colorimetric kinetic methods. Data of decreased serum creatinine levels were analyzed using ANOVA test, followed by Fischer's LSD, ? = 0.05. All doses of CML-RGRE were very effectively inhibited the increase of serum creatinine levels (p < 0.01). The concoction Moringa leaves, and Red Ginger Rhizome ethanol extract has effectively inhibited the increase of serum creatinine levels of animal dyslipidemia models.
Hubungan antara Durasi Penggunaan Gawai Selama Masa Pandemi COVID-19 dengan Computer Vision Syndrome pada Mahasiswa FK Unika Atma Jaya Jakarta
Authors: R Tanjung Julia , T Tantra Cornelia , Sudiyono Nelson
Published: February 2023

Pandemi COVID-19 berimbas pada peningkatan durasi penggunaan gawai untuk kegiatan pendidikan daring yang berdampak buruk bagi kesehatan mata, salah satunya, Computer Vision Syndrome (CVS). Penelitian ini bertujuan untuk mengetahui hubungan durasi penggunaan gawai dengan CVS pada mahasiswa kedokteran Fakultas Kedokteran dan Ilmu Kesehatan Universitas Katolik Indonesia Atma Jaya. Metode penelitian potong lintang dengan 98 responden (76 perempuan, 22 laki-laki) berusia 17-21 tahun, menggunakan Modified computer vision syndrome questionnaire dan aplikasi pengukur durasi penggunaan gawai. Rerata durasi penggunaan gawai adalah 610 menit per hari. Sebanyak 70% responden menggunakan gawai dengan rerata durasi >8,9 jam per hari. Prevalensi CVS ditemukan sebesar 47,9%, dimana 25,5% responden mengalami CVS derajat ringan dan 22,4% responden mengalami CVS derajat sedang hingga berat. Analisis Bivariat dengan uji Chi-square memperlihatkan hubungan yang bermakna antara durasi penggunaan gawai dengan derajat keparahan CVS (p<0,05). Simpulan penelitian ini, terdapat hubungan antara durasi penggunaan gawai dengan derajat keparahan Computer Vision Syndrome pada mahasiswa Fakultas Kedokteran Unika Atma Jaya Jakarta selama masa pandemi Covid-19.
Rancang Bangun Sistem Keamanan Pintu menggunakan Metode Pengenalan Wajah berbasis Internet of Things
Authors: Handayani Trie , Basuki Arif , Sudiana Sudiana , Dirgantara Ilham
Published: February 2023

Penelitian ini dilakukan untuk membuat prototipe sistem keamanan pintu dengan metode pengenalan wajah untuk mengendalikan kunci solenoid pada sebuah pintu. Sistem ini dibuat berbasis Internet of Things (IoT) berfungsi mengendalikan kunci solenoid dan bertukar informasi secara real time. Kunci solenoid akan terbuka secara otomatis saat sensor kamera menangkap citra wajah dan dicocokkan dengan citra yang sebelumnya sudah direkam dan disimpan di database sistem. Sistem dapat dikendalikan menggunakan smartphone/komputer yang terhubung melalui aplikasi Telegram Messenger. Hasil berupa sistem deteksi pengenalan wajah untuk membuka kunci solenoid dengan akurasi 92%. Sistem mampu membuka kunci solenoid secara otomatis berdasarkan kesesuaian citra. Rata-rata waktu pengiriman notifikasi berupa citra dan teks adalah 4 detik dan 0,5 detik. Dengan kata lain sistem telah bekerja dengan baik.
Analisis Pengukuran Layanan LTE di Jalan Daan Mogot dari Kota Tangerang sampai Kota Jakarta Barat dan Perbaikannya
Authors: Aliansyah Muhammad Fadly , Usman Uke Kurniawan , Setiawan Dhoni  Setiawan Putra
Published: February 2023

Penelitian ini didahului dengan melakukan LTE Drive Test sebanyak dua kali pada Jalan Daan Mogot dengan layanan yang berbeda, dan mendapatkan nilai persentase 95% RSRP, SINR, dan RSRQ yang tidak memenuhi standar key performance indicator dari operator. Pada jalan ini juga ditemukan beberapa kasus seperti radio link failure, handover failure, dan connection drop serta 6 area bad spot. Perbaikan telah dilakukan dengan Aplikasi Atoll menggunakan empat metode usulan perbaikan, yaitu: physical tunning, mengubah power antena secara homogen, menggunakan site terdekat untuk melayani area yang bad spot, dan melakukan penambahan site baru. Setelah dilakukan perbaikan dari 6 bad spot, didapat rata–rata nilai RSRP -97.71 dBm, SINR 11.32 dB, RSRQ -13.8 dB, dan throughput 57,868.92 kbps. Dengan metode utama perbaikan adalah physical Tunning.
Training the trainers: improving the quality of education delivered to paramedics through a simulation-debrief model
Authors: Avery Pascale , Thompson Charlotte , Cowburn Philip
Published: February 2023

Introduction: Education and training delivered within ambulance services is vital to clinicians maintaining competence, confidence and currency. Simulation and debrief in medical education aims to imitate clinical experience and provide real-time feedback. The South Western Ambulance
Service NHS Foundation Trust employs senior doctors in their learning and development (L&D) team to support the development of ‘train the trainer’ courses for L&D officers (LDOs). This short report of a quality improvement initiative describes the implementation and evaluation
of a simulation-debrief model of paramedic education.Methods: A quality improvement design was adopted. The train the trainer scenarios for simulation-debrief were designed and written following the trust’s training needs analysis by the L&D team. The course ran for two
days, and each scenario was facilitated by faculty experienced in simulation (both doctors and paramedics). Low-fidelity mannequins and standard ambulance training kit was used (including response bags, training monitor and defibrillator). Participants’ pre- and post-scenario self-reported
confidence scores were recorded, and qualitative feedback requested. Numerical data were analysed, and collated into graphs using Excel. Thematic analysis of comments was used to present qualitative themes. The SQUIRE 2.0 checklist for reporting quality improvement initiatives was used to
frame this short report.Results: Forty-eight LDOs attended across three courses. All participants reported improved confidence scores in the clinical topic covered after each simulation-debrief scenario, with a minority reporting equivocal scores. Formal qualitative feedback from
participants indicated an overwhelmingly positive response to the introduction of simulation-debrief as an education method, and a move away from summative, assessment-based training. The positive value of a multidisciplinary faculty was also reported.Conclusion: The simulation-debrief
model of paramedic education represents a move away from the use of didactic teaching and ‘tick box’-style assessments in previous train the trainer courses. The introduction of simulation-debrief teaching methodology has had a positive impact on paramedics’ confidence in
the selected clinical topics, and is seen by LDOs as an effective and valuable education method.
Homofobia-transfobia en Latinoamérica y la alternativa de la figura de la demanda de asilo a Canadá antes de las políticas anti-inmigratorias
Authors: Duque Mata Ana Alejandra , Pizarro Hernández Karina
Published: February 2023

Con este trabajo de investigación se pretende conocer las prácticas discriminatorias que se ejercen en México y que llevaron a algunes[1] mexicanes pertenecientes a la comunidad Lésbico, Gay, Bisexual, Transexual, Travesti, Transgénero, Intersexual,  Queer y Asexual (LGBTTTIQA+)[2] a migrar a Canadá. El propósito es dar a conocer algunos casos de personas de la comunidad LGBTTTI, que por su condición de género fueron discriminadas en su país de origen propiciando una migración forzada y que posteriormente solicitaron una demanda de asilo como alternativa para poder obtener una residencia permanente por medio del estatus de refugiades en Canadá. Estos personajes buscaron una oportunidad para vivir y convivir en sociedad multicultural, sin temor a ser discriminados o violentados por su condición de género y preferencia sexual. El presente estudio tiene un carácter histórico, pues muestra las experiencias antes de las políticas anti inmigratorias de Canadá.
Analysis Of Halal Labels on Food Ingredients in Nutrition Installation of Islamic Hospital Sultan Agung Semarang
Authors: Yuni Damayanti Amilia , Nurul Khiqmah Atika , Husnul Abidah Yusrina , Husnul Abidah Yusrina , Syafitri Hilda Ayu , Hardiah Muayyanah , Putri Ashifa Purnama , Annayah Sofiatun
Published: February 2023

Halal is the main parameter in the product selection process for Muslims. Ensuring that the food consumed is halal is the responsibility of every Muslim. This study aims to analyze the halal label on food ingredients. The research design used in this research was descriptive research. The location of this research was the Nutrition Installation of Sultan Agung Islamic Hospital (RSISA). The time of the study was carried out in August 2019. The number of food ingredients contained in the RSISA Nutrition installation was 565. Analysis of halal labels on food ingredients in the nutrition installation at RSISA used an early warning system in the form of an application on a computer. There were colors grading as an indication of the validity period of the halal certificate. The blue color indicates that the validity period of the halal certificate is 1.5-2 years, the green color is 1-1.5 years, the yellow color is 3 months -1 year, the red color is less than 3 months, and the gray color indicates that the validity period Halal certificate has expired. The validity period of the halal label on each food ingredient provided at the RSISA Nutrition Installation was the highest for materials with a halal certificate period of 1-1.5 years with a percentage of 34.7% and the lowest was materials with a halal certificate period of less than 3 months with a percentage of 6,3%.
Psychosocial Dynamics of The Decision Marry Young In Lombok East NTB Distric
Authors: Bafadal Iqbal , Halimatussakdiah
Published: February 2023

In many studies it has been mentioned the impact of marrying young whose dominant proportion is more to the negative side. But in reality, there are still many who do marriage at a young age. The purpose of this study is to uncover the psychosocial dynamics of young marriage decision making both internally and externally and how the two aspects collaborate in providing encouragement for marriage decision making at a young age. The other side of the establishment of the main objectives is the exposure of the causative aspects of marriage on the internal and external sides of the individual. The research conducted uses a descriptive qualitative approach. Where researchers collect data through active interviews openly and closedly as a primary data source method. The focus of the group discusion, observation and understanding of the supporting document evidence as a secondary source. Analyzing the findings in depth, researchers reduce data, present data in the form of narratives, verify data and then draw conclusions. The results of the study found that the decision to marry at a young age is predominantly influenced by external factors rather than the internal side of the individual. The power of external factors exerts an influence on the speed of decision-making to get married. The will on the internal side of the individual is low on the side of interpersonal attraction, the competition side, and the diversion of boring or exhausting activities. However, due to the friction of external factors such as the pressure of high expectations and desires of parents, the fulfillment of family expectations, the economic demands of the family, feelings of anger towards parents or family and the atmosphere of the friendship environment become a source of strength in making decisions to get married even though it is still at a fairly young age.
Religious Coping: Is It Effective to Reduce Parent's Stress During the Parenting of Special Needs Children?
Authors: Herlina Herlina , Kosasih Ismawati , Dahlan Tina Hayati
Published: February 2023

The study aims at determining the impact of religious coping on the stress endured by parents of children with special needs. It was conducted using a quantitative approach. The subjects of the study were 122 parents of special needs children, selected using accidental sampling technique. For this study, the Indonesian rendition of Amer et. al's BARCS was used as an instrument to measure the religious coping, while Berry & Jones' Parental Stress Scale was adapted to determine the stress level during the parenting of the children. The data were processed using Variance Analysis and Pearson Correlation statistical technique. The result shows that: 1) the use of religious coping in parenting the children with special needs is on a moderate level, 2) the highest level of stress was noticed on parents of children with a learning disability, in comparison with other disabilities or special needs, 3) the religious coping affected contrastingly on the parents' stress; the higher the use of the coping, the lower the stress level endured by the parents while handling their special needs children, and vice versa.
Steps of Patience According to Tarekat Practitioners
Authors: Intaning Qurota A’yun  , Nur Aziz Afandi  , Niken Agustina
Published: February 2023

Calamity is something that cannot be avoided by everyone. Patience is a word that is often conveyed to people who are experiencing calamities so that they can survive and not give up. In practice, it turns out that to be patient one requires stages that must be passed. This study aims to examine the steps to be patient when facing difficulties according to Tarekat practitioners. This research is a qualitative research with interviews as a collection data technique on the subject of Tarekat practitioners. The research finding regarding the first steps of patience, is by remembering Allah. Second, believing in the determination of Allah. Third, being Husnudhon or think positively to Allah. Fourth, accepting and being grateful for Allah's destiny. The fifth is looking for a spiritual teachers
ASSESSMENT OF KNOWLEDGE AND PRACTICE OF CHILD CARE AMONG MOTHERS OF ONE TO THREE YEARS CHILDREN IN A SELECTED RURAL AND URBAN COMMUNITY. KOLKATA, WEST BENGAL
Authors: Dutta Krishna
Published: February 2023

The investigator conducted a comparative descriptive study to assess Knowledge and Practice of Childcare among Mothers of One to Three years children in a selected rural and urban community. Kolkata, West Bengal. She selected 50 rural mothers and 50 urban mothers using non-probability purposive sampling technique. The conceptual framework is based on Barnard Child health assessment model. Semi Structured and structured interview schedule used for data collection. Result showed that mean knowledge score between rural mothers and urban mothers statically significant as evidenced by calculated‘t’ value 11.42 at 0.05 level of significance . The difference of mean Practice score between rural mothers and urban mothers statically significant as evidenced by calculated‘t’ value 13.75 at 0.05 level of significance. There was relationship between knowledge and practice (0<0.67<1) and (0<0.71<1), in rural and urban community, respectively.The findings of study have implications in the field of Community Health Nursing, Nursing Administration and Nursing Research.
PREVENTION AND DETECTION OF INTRUSION IN CLOUD USING HIDDEN MARKOV MODEL
Authors: Deep Bhavya , Jain Aman
Published: February 2023

Cloud computing is one of the fast-growing technologies in recent times. People are adopting cloud services often and they do not possess any other substitute for its services. At the same time, users have to be aware of privacy and security issues in the cloud environment. Due to the distributed nature of cloud computing, multi-domain support, and multi-user platform, the cloud-based system is more vulnerable to security threats. Security threats can be distributed denial of service attacks and intrusion prospects. Thus, organizations need to have techniques like intrusion detection as well as prevention, firewalls, encryption, authentication, etc. for securing the stored information on the cloud. Intruders attempt to identify loopholes to break security. For that, organizations are adopting the system for intrusion detection and prevention to provide privacy and security in the cloud environment. Attacks whether internal or external must be prevented and thus it is significant to adopt the technique of preventing and detection system for identifying intrusion. Therefore, this research intends to study the prevention and detection of intrusion in the cloud environment.
Teachers' Views on Ecological Literacy Skills
Authors: Çınar Gülcan , Selman Tuğba , Tuncer Tansel , Çakan Şengül , Ağgünlü Ahim , Arslankılıç Meryem
Published: February 2023

21'inci yüzyılda çevre okuryazarı olan kişiler, ekosistem çerçevesinde hem insanları hem de ekolojiyi geliştirmek için çalışan sorumlu, yaşam boyu öğrenen kişiler olarak kabul edilmektedir. Bu kişiler bilişsel, duygusal, psikomotor,
iç gözlemsel, sezgisel, estetik, sosyal ve yaratıcı düşünme gibi çeşitli becerileri dengeli bir şekilde geliştirmek için çaba gösterirler. Böylece insanlar yaşamın anlamını ve amacını keşfedeceklerdir. Gerçekte, doğayla etkileşimin
insanların entelektüel, fiziksel ve zihinsel olarak gelişmesine yardımcı olduğu açıktır. Büyürken bu temasa tanık olan çocuklar büyük hayat dersleri alacak ve tüm canlılar için şefkat geliştireceklerdir. İngiltere gibi birçok Batı
ülkesinde ekolojik eğitim genellikle ilkokul düzeyinde özel okullarda verilirken, Türkiye'de yaygın değildir. Bunun nedeni, Türkiye'de çevre eğitiminin gerektiği gibi uygulanmamasıdır. Bu çalışmanın temel amacı öğretmenlerin ekolojik
okuryazarlığı becerileri hakkında ne düşündüklerini belirlemektir. Çalışmada nitel araştırma yöntemlerinden temel nitel araştırma deseni tercih edilmiştir. Bu araştırmanın çalışma grubunu 2022-2023 eğitim-öğretim yılında Ankara
ilinde Milli Eğitim Müdürlüğüne bağlı toplam 2 okulda görev yapmakta olan 14 öğretmen oluşturmaktadır. Bu araştırmada veriler araştırmacılar tarafından geliştirilen yarı yapılandırılmış görüşme formu aracılığıyla toplanmıştır.
Bu çalışmada elde edilen veriler temel olarak içerik analizi tekniğiyle çözümlenmiştir. Çalışmadan elde edilen bulgulara göre öğretmenlerin ekolojik okuryazarlığı becerilerinin çeşitliliği ve bu becerinin müfredata dahil edilme
gerekçeleri konusunda makul sayılabilecek bir bilgi düzeyine sahip oldukları görülmüştür.
Considerations on the Execution of a Grand Vizier
Authors: Furkan ÖREN Mehmet , Turan Ömer Faruk , Kayacan Nurettin
Published: February 2023

Önceden beri Osmanlı tarihine karşı özel bir ilgimiz vardı. Onun için bu sahada çalışma yapmayı çok arzu ediyorduk. Bu fırsat nihayet böyle bir makale vesilesiyle elimize geçmiş oldu. Bu vesile ile Osmanlı tarihinin önemli olaylarından
biri olan veziriazam katillerini araştırmaya karar verdik. Bu aşamada Osmanlı tarihindeki vezir katillerinin ilki olan Sultan ll. Mehmet’in vezirlerinden Çandarlı Halil Paşanın katledilmesi bu katillerin belki de içlerinde en kritik
olanıydı. Osmanlı tarihindeki hem ilk vezir katli olması, hem de bu vezirin Osmanlı devletinin kuruluşundan beri Osmanlı hanedanıyla sürekli birlikte hareket eden Çandarlı ailesinin bir mensubu olmuş olması, mezkûr katli diğer
vezir katillerinden ayıran önemli özelliklerden birisiydi. Biz de bu ilginçliğin peşinden giderek Osmanlı döneminin katledilen ilk vezir-i azamı Çandarlı Halil Paşanın katlini incelemeye karar verdik. Bilindiği üzere tarihimiz
hala aydınlığa kavuşmamış bir sürü meçhul hadiselerle doludur. Hiç şüphesiz bunlardan bir kısmını da katiller ve özellikle de vezir-i azam katilleri oluşturmaktadır. Bu tür hadiselerin mahiyetini anlamak ve aydınlığa kavuşturmak
için gayretli çalışmalar ve araştırmalar gereklidir. Konu hakkında yapılacak olan araştırmalar tarihimizin gerçek yanlarını ortaya çıkarmak ve doğru bilgilere ulaşmak açısından da önem arz etmektedir. İşte biz de ummandan bir katre
misali de olsa, konu hakkında bir araştırma yapmaya ve ulaştığımız hakikatleri makalemizle ehline ulaştırmaya çalıştık. Araştırmalarımızda, imkânlarımız dâhilinde konuyla alakalı birinci elden kaynaklara göz atmaya gayret ettik.
Bu çalışmamızda bizden yardımlarını eksik etmeyen tüm hocalarıma ve dostlarıma teşekkürü bir borç bilirim. Her halükarda tek yardımcımız Allah’tır ve O, ne güzel Mevla, ne güzel yardımcıdır.
Determining the Characteristics of Leader School Administrators According to School Administrators
Authors: Yiğit Engin , Kılçar Alim , Alaylı Halil
Published: February 2023

Bu araştırmanın temele amacı lider okul yöneticilerinde bulunması gereken özellikleri okul yöneticisi görüşlerine göre belirlemektir. Araştırma temel nitel araştırma desenine göre yürütülmüştür. Araştırmanın çalışma grubunu 2022-2023
eğitim öğretim yılında ilk ve orta dereceli okullarda okul yöneticisi olarak görev yapan 12 yönetici oluşturmaktadır. Bu çalışma kapsamında yarı yapılandırılmış görüşme formuna yönelik literatürdeki bilgiler çerçevesinde araştırmacı
tarafından görüşme formu hazırlanmıştır. Hazırlanan görüşme formunda araştırma soruları çerçevesinde katılımcılara 4 soru sorulmuştur. Araştırmada elde edilen verilerin analizinde betimsel analiz yöntemi kullanılmıştır. Araştırmadan
elde edilen bazı sonuçlarına göre: Okul yöneticilerinin yöneticilik özellikleri olarak iletişim becerisi gelişmiş, bilgi ve donanımı olan, adaletli, vizyon sahibi, işbirliği yapabilen, planlı, zamanı yönetebilen, kriz yönetebilen,
liyakat sahibi, rehberlik edebilen, motive edebilen, çözüm odaklı olmaları gerektiğini belirtmişlerdir.
Cognitive Biases in Finance and Marketing Literature: A Meta-Analysis Approach
Authors: Erol Kader
Published: February 2023

Cognitive biases are in the focus of attention of both marketing and finance, as they are highly influential in the decision-making process of consumers and investors. In proportion to this effect size, it is observed that the studies
on this subject in the marketing and finance literature have increased in recent years. In this study, it is aimed to analyze the studies published and indexed in two important international databases since 2015, the time period
when cognitive biases started to come to the fore in the context of economy and business. Due to the importance of cognitive biases in economic decisions, within the scope of this study, thirteen different cognitive biases were
examined from the perspectives of finance and marketing disciplines and scanned in two national and international databases (Web of Science and Scopus), and finally 313 articles were accessed within the framework of the limitations
of the study. As a result of the analyzes and bibliographic data visualization, it was determined that cognitive biases were studied more intensively in the field of finance compared to the field of marketing. Another important
finding is that cognitive biases are mostly researched together with the "risk" phenomenon in both marketing and finance. That is, most of the studies on this subject have focused on revealing the relationship between the perceived
risk in the decision-making phase and the cognitive biases that individuals have. In future studies, it is thought that evaluating different types of cognitive biases together with various variables may contribute to both marketing
and finance literature.
O AGENTE COMUNITÁRIO DE SAÚDE E O TRABALHO INTERVENTIVO COM FAMILIARES DE USUÁRIOS DE ÁLCOOL E/OU DROGAS EM ESTRATÉGIAS SAÚDE DA FAMÍLIA EM GUANAMBI- BAHIA
Authors: Rodrigues Mônica Xavier Santana
Published: February 2023

O Agente de Saúde Comunitária (ACS) é um profissional que faz parte da equipe multidisciplinar nos serviços de Atenção Básica à Saúde. Esse profissional realiza atividades de promoção da saúde e prevenção de doenças com foco em atividades de educação em saúde, nos domicílios e na comunidade. O ACS é considerado o elo que integra a atenção primária à saúde com a comunidade.
No desenvolvimento de seu trabalho os Agentes Comunitários de Saúde (ACS) responsáveis por realizar visitas domiciliares, ouvir relatos da comunidade identificando problemas de saúde e agravos e comunicar as necessidades da população à equipe da Estratégia Saúde da Família (ESF). Eles se destacam por sua capacidade de se conectar com as pessoas e pela liderança natural que demonstra para atender às necessidades
de cada família, visando a melhoria da saúde física e mental do indivíduo.
A saúde mental é parte integrante e complementar da conservação das funções do
organismo. Por isso, a promoção da saúde mental é fundamental para que o indivíduo tenha a capacidade necessária para exercer suas competências pessoais e profissionais.
Vários fatores podem colocar em risco a saúde mental das pessoas. Entre eles, repentinas mudanças sociais, situações de stress no trabalho, discriminação por condição sexual, exclusão social, violência e violação de direitos, estilos de vida com uso/abuso de álcool e outras drogas.
Compreender os riscos e as consequências do uso de drogas na saúde mental e física é um dos aspectos mais importantes para conter os efeitos negativos do problema. Além dos danos ao organismo de quem a consome, o uso de drogas também leva a problemas sociais, econômicas e principalmente familiares.
Raising awareness in sustainable environment education: Waste batteries
Authors: Celikler Dilek , Aksan Zeynep , Yilmaz Ayhan
Published: February 2023

The aim of this study is to provide training for science teachers on batteries, areas of use of batteries, types of batteries, things that should be paid attention to while using batteries, waste batteries, and collection, handling, recovery and/or disposal of waste batteries, and help teachers receiving the training to raise awareness among grade 5 students on these issues. The study was carried out with 58 science teachers and 575 secondary school grade 5 students. Within the scope of the study, a detailed training on the issue was provided to the teachers and attempts at raising awareness among students in four lessons were made by the teachers receiving the training. Data were obtained by making students draw “adventure of the waste battery” themed pictures and write “story of the waste battery” themed compositions as a pre-test before the workshop and a post-test after the workshop. Data were analyzed using content analysis. As a result of the study, it was observed that awareness was raised among students on the elements available in batteries, battery powered objects, points of disposal for waste batteries, places of waste battery bins, recycling of waste batteries, positive effects of collection of waste batteries, negative effects of waste batteries, and things to be done to avoid these negative effects.
Determining the graphical literacy levels of the middle school mathematics teachers
Authors: Uyanik Sefa , Elbir Dilara , Ozmen Zeynep Medine
Published: February 2023

This study aims to determine the graphical literacy levels of middle school mathematics teachers. The participants of the study consisted of 33 middle school mathematics teachers working in different provinces. The data of the study were collected with the help of the graphical literacy test created by the researchers. The data were analyzed by content analysis method. As a result of the study, it was seen that the teachers were more successful in the questions that required reading the data in the graph. It has been revealed that teachers are unsuccessful in reading beyond data questions that require higher-level thinking. In addition, the teachers had the most difficulty creating the graphs. In other words, it was determined that the graphical literacy levels of the teachers were low. Therefore, it is thought that studies to improve the graphical literacy skills of teachers in in-service training programs will be important.
Oxidative Stress and Antioxidant Status in Colorectal Cancer and Healthy Subject
Authors: Mahmood Noah A.
Published: February 2023

Background: Total antioxidant status (TAO), superoxide dismutase (SOD) and Catalase (CAT) areantioxidant defensive enzymes that are catalyze the reduction of reactive oxygen species (ROS) to nonharmful substance. Aim: The study focuses on the serum super oxide dismutase enzyme level, CAT level andtotal antioxidant status in colorectal cancer patients, which result due to an imbalance between aggressiveand defensive factors. Materials and Methods: the study included 40 patients and 20 healthy individuals forcomparative analysis were considered for the present study. (TAO), serum (SOD) and (CAT) levels of eachindividual were performed. Results: Statistical analysis of serum antioxidant enzymes level and antioxidantstatus revealed a significant increase in SOD, CAT of patients group (p.≥0.05), and (P.≥0.01) respectively. The TAO was significant increase (p.≥0.001). The increasing preponderance of serum SOD, CAT levelsand the TAO can be explained on the basis of alteration on enzymes activity, which may lead to disturbancein homeostasis of antioxidant/oxidant balance... Conclusions: TAO, Catalase and Superoxide dismutaseenzyme used a biomarker of enzymatic alteration in different diseases including cancer.
Sexual dimorphism of ducks (Cairina moschata, Linnaeus 1758) reared in the southern forest of Côte d’Ivoire
Authors: Logboh Emma Gladys Akou LOBA-MESSET  , Innocent Béhiri KAKOU  , Djibril Mitantè YEO  , Dofara SORO  , Béatrice Abouo ADEPO-GOURENE
Published: February 2023

Sexual dimorphism was studied on 213 ducks including 92 males and 121 females of the species Cairina moschata in the southern forest of Côte d'Ivoire. Measurements were made using a tape measure and weighing with an electronic scale. A step-wise discriminant analysis made it possible to examine 21 morphometric descriptors. All linear measures except beak and head with were significantly higher in males than in females. 18 of these 21 parameters are statistically significant with the Mann-Whitney U test. Of these 18 significant descriptors, nine are strongly correlated positively for the first two and the fourth axis while it is negatively for the third factorial axis. The projection of the individuals in the plane of the principal component analysis shows a separation of the batches so that along axis 1 the male individuals gather towards the negative coordinates and the female individuals towards the positive coordinates. The values ​​recorded with the discriminant factor analysis confirm to 92.49% the membership of the specimens to the different defined groups. This analysis proposes a reclassification of two females in the group of males and of 14 males among the females.
Comparing and evaluating influence of nylon fiber and fly ash in self compacting concrete
Authors: Muhammad Murtaza  , Mehtab Ur Rehman  , Zhang Jinxi
Published: February 2023

Self-consolidating concrete (SCC) is a special concrete that is highly flow able, non-segregating and self-expanding. Self-compacted concrete (SCC) is poured into the formwork without compaction and fills the formwork by its own weight. SCC is considered to have many advantages. Compared with conventional concrete as improved Construction quality, faster construction activity, lower cost etc. This project was carried out to evaluate the effects of addition of nylon fiber and fly ash on the fresh and hardened properties of SCC mixes. In this project, concrete mixes with nylon fiber of 0.5%, 1.5%, 2.5%, and fly ash with 0%, 15%, 30% and 45% were used to determine its permeability, flow Capacity, evaluated on the basis of and separation resistance, slump flow, L-box and V-funnel tests. After 3 days, 14 days, 28 days of curing SCC cylinders, compressive and splitting tensile strength were tested. The test results show that nylon fibers increase permeability but decrease the filling capacity and segregation resistance of SCC. Furthermore, it can be concluded that after 3 days, 14 days, 28 days of curing, the test of concrete samples showed that the addition of nylon fiber up to 2.0% of cement by volume increased the compressive strength of SCC. Strength, improves tensile strength but 2.5%. Nylon fiber reduces the compressive strength, tensile strength of hardened SCC.
Contribution of regional integration to economic development of member states, case study: East African community (EAC)
Authors: Ali Keya Anami
Published: February 2023

The main focus of this paper is about the contribution of regional integration on economic development to member states with East African community as our case study. The efforts of EAC in pursing integration dates back to the colonial periods, it is one of the oldest regional economic communities in African continent with its headquarters in Arusha, Tanzania. The researcher used historical and descriptive analysis method in the study, with reference from secondary data related to this study. The study concluded that EAC integration has promoted trade creation as all the partners have experienced economic growth due to the integration process and therefore recommended that EAC’s success depends on the support and commitment it gets from the member states. Moving towards a Common Market, the progressive institutionalization of key organs is fundamental in sustained integration process.