bluuebunny/crossref_metadata_2025 huggingface dataset:
In Silico Approach for Designing a Novel Recombinant Fusion Protein as a Candidate Vaccine Against HPV
Authors: Sisakht Mohsen , Mahmoodzadeh Amir , Zahedi Mohammadsaeid , Rostamzadeh Davood , Hasan-Abad Amin Moradi , Atapour Amir
Published: October 2020

Background:

Human Papillomavirus (HPV) is the main biological agent causing Sexually
Transmitted Diseases (STDs), including precancerous lesions and several types of prevalent cancers.
To date, numerous types of vaccines are designed to prevent high-risk HPV. However, their
prophylactic effect is not the same and does not clear previous infections. Therefore, there is an urgent
need for developing therapeutic vaccines that trigger cell-mediated immune responses for the
treatment of HPV. The HPV16 E6 and E7 proteins are ideal targets for vaccine therapy against
HPV. Fusion protein vaccines, which include both immunogenic interest protein and an adjuvant
for augmenting the immunogenicity effects, are theoretically capable of guaranteeing the power of
the immune system against HPV.

Methods:

A vaccine construct, including HPV16 E6/E7 proteins along with a heat shock protein
GP96 (E6/E7-NTGP96 construct), was designed using in silico methods. By the aid of the SWISS--
MODEL server, the optimal 3D model of the designed vaccine was selected, and then the physicochemical
and molecular parameters were performed using bioinformatics tools. Docking studies
were done to evaluate the binding interaction of the vaccine. Allergenicity, immunogenicity, B,
and T cell epitopes of the designed construct were predicted.

Results:

Immunological and structural computational results illustrated that our designed construct
is potentially proper for stimulation of cellular and humoral immune responses against HPV.

Conclusion:

Computational studies showed that the E6/E7-NTGP96 construct is a promising candidate
vaccine that needs further in vitro and in vivo evaluations.
Multicomponent Reactions of Indoles with 1-Amino-5-aroyl-4-aryl-1HPyrimidin- 2-ones / -thiones: One-pot Three Component Synthesis of Novel Gramine Analogues
Authors: Aydın Hava , Korkusuz Elif , Yıldırım İsmail
Published: October 2020

A one-pot three component synthesis of a series of new gramine derivatives was designed
and achieved via reactions of indole or N-methylindole with aromatic aldehyde and heteroaryl
amines at 80-110 °C for 10-24 hours in an oven under solvent- and catalyst-free conditions
providing an efficient, convenient and green method for the syntheses of a series of indol-3-yl- and
N-methylindol-3-yl-1-aminopyrimidin-2-ones/thiones. So, fourteen novel gramine derivatives were
conveniently synthesized and characterized by elemental analyses, FT IR, 1H and 13C NMR spectroscopic
measurements.
The Role of Reactive Oxygen Species, Kinases, Hydrogen Sulfide, and Nitric Oxide in the Regulation of Autophagy and Their Impact on Ischemia and Reperfusion Injury in the Heart
Authors: Krylatov Andrey , Maslov Leonid , Tsibulnikov Sergey Y. , Voronkov Nikita , Boshchenko Alla , Downey James , Mentzer Robert
Published: October 2020

:

There is considerable evidence that autophagy in cardiomyocytes is activated by hypoxia/
reoxygenation (H/R) or in hearts by ischemia/reperfusion (I/R). Depending upon the experimental
model and duration of ischemia, increases in autophagy in this setting maybe beneficial (cardioprotective)
or deleterious (exacerbate I/R injury). Besides the conundrum as to whether or not autophagy
is an adaptive process, it is clearly regulated by a number of diverse molecules, including
reactive oxygen species (ROS), various kinases, hydrogen sulfide (H2S) and nitric oxide (NO). The
purpose of this review was to address briefly the controversy regarding the role of autophagy in
this setting and to examine a variety of disparate molecules that are involved in its regulation.
Stem Cells in Rotator Cuff Injuries and Reconstructions: A Systematic Review and Meta-Analysis
Authors: Liu Fanxiao , Meng Qingqi , Yin Heyong , Yan Zexing
Published: October 2020

Current Stem Cell Research & Therapy, 2019, 14(8): 683-697

Heyong Yin’s affiliation should be: Department of Orthopaedics, Beijing Friendship Hospital, Capital Medical University,
Beijing China;

Zexing Yan’s affiliation should be: Department of Orthopaedics, Shandong Provincial Hospital Affiliated to Shandong
University, No.324, Road Jing Wu Wei Qi, Jinan 250021, Shandong, China.

The Original Paragraph Provided is Mentioned Below:

Fanxiao Liu1, Qingqi Meng2, Heyong Yin3,* and Zexing Yan3,*

1Department of Orthopaedics, Shandong Provincial Hospital Affiliated to Shandong University, No.324, Road Jing Wu
Wei Qi, Jinan 250021, Shandong, China; 3Department of Trauma Surgery, University of Regensburg, Am biopark 9,
93049 Regensburg, Germany
Prevalence and Clinical Profile of Undiagnosed Diabetes Mellitus: Data from a Tertiary Hospital
Authors: Phan Hen H. , Lam Hoang V. , Le Nhan T. , Le Huy N. , Tran Diem T. , Tran An V. , Mai Thao P. , Do Minh D.
Published: October 2020

Background:

The prevalence of diabetes mellitus in Vietnam is relatively low compared
to other Asian countries, but it is accelerating with the economic and cultural transition. This study
aimed to estimate the current prevalence and clinical profile of undiagnosed diabetes mellitus in a
tertiary hospital in the south of Vietnam.

Methods:

A cross-sectional investigation was conducted to recruit 1, 250 participants, who were at
least 18 year-old and randomly sampled from Cho Ray Hospital, Ho Chi Minh City, Vietnam. Fasting
plasma glucose concentration and HbA1c were measured for each individual. The American Diabetes
Association criteria were used to diagnose diabetes. Demographic data and other clinical
characteristics of diabetes were also documented, including age, sex, residence, educational status,
weight, height, waist and hip circumferences, blood pressure, familial history of diabetes, and lipid
profile.

Results:

The prevalence of undiagnosed diabetes mellitus was 7.5% in the population studied.
Age, waist circumference, waist-hip ratio, body mass index, and hypertension, as well as dyslipidaemia
were well-correlated with the diabetes rate.

Conclusion:

The prevalence of undiagnosed diabetes mellitus is increasing far more than expected.
Newly diagnosed diabetic patients usually presented with multiple comorbidities, including overweight/
obesity, hypertension, and dyslipidaemia.
Bacteriological Quality and Antibiotics' Susceptibility Profile of Small-medium Scale Commercial Fish farms in Nigeria
Authors: Fakorede Cecilia Nireti , Fatokun Evelyn Nwadinkpa , Philip-Kantiok Blessing , Iwu Chinwe Juliana , Jaja Ishmael Festus
Published: October 2020

Background:

Fish currently provide 6.7% of all proteins consumed by humans globally; nevertheless, the aquaculture system has been linked to fish, environmental contamination and disease outbreak. The aim of this study was to determine the bacteriological quality and the antibiotic resistance profile of bacteria from water samples of pond stocked with Tilapia and Catfish in Ile-Ife, Osun State, Nigeria.

Objective:

To isolate, identify and characterise heterotrophic bacteria and test for the antibiogram of detected Coliforms.

Methods:

Water samples were collected from ponds stocked with Tilapia and Catfish, and tested for total heterotrophic and coliform bacteria as well as the antibiogram. The susceptibility of the isolates was tested using the Kirby-Bauer disc diffusion method on Mueller Hinton agar.

Results:

A total of 40 isolates were recovered from the water samples, of which 5 species were Gram positive bacteria representing two genera, and 35 species were Gram negative bacteria representing four genera. The temperature for all ponds ranged from 25°C to 28°C. The mean bacterial count varied from 1.9×104 to 5.4×104 CFU/ml per fish pond. All isolates were 100% resistant to ceftazidime, cefuroxime and augmentin. More resistance to cefixime (80%) and gentamicin (73.3%) and nitrofurantoin (66.7%) was also recorded. However, only 16.6% and 8.3% of the isolates were resistant to ciprofloxacin and ofloxacin, respectively. The multiple antimicrobial resistance index (MARI) ranged from 0.5 to 0.9. The water physicochemical parameters (temperature and pH) and the type of bacteria detected in all pond types did not differ significantly.

Conclusion:

Fish pond is a reservoir of multi-drug resistant bacteria that could serve as environmental source of drug resistance gene transfer. This calls for effective monitoring and assessment as well as management devices for the protection of community and environmental health.
Synthetic Lung Surfactant Treatment for COVID-19 Pneumonia
Authors: Walther Frans J. , Waring Alan J.
Published: October 2020

COVID-19 has led to morbidity in millions of patients, ranging from mild flu-like symptoms
to severe respiratory failure, necessitating oxygen supplementation and mechanical ventilation, and ultimately
death. The SARS-CoV-2 virus reacts with angiotensin-converting enzyme 2 (ACE2) molecules
that are especially found in alveolar epithelial type 2 cells in the lungs and thereby causes a loss in lung
surfactant, a protein-lipid mixture that is crucial for both native immunity and reduction of surface tension
in the lung alveoli. Lung surfactant insufficiency results in atelectasis and loss of functional lung
tissue amid an inflammatory storm and may be countered by treating COVID-19 pneumonia patients
with exogenous lung surfactant, preferably by aerosol delivery of a novel dry powder synthetic lung surfactant.
More research on timing, dosing, and delivery of synthetic lung surfactant in patients with
COVID-19 pneumonia is of crucial importance to implement this approach in clinical practice.
Focus on three research themes undertaken by Dr. YC Lee
Authors: Lee Ying-Chieh
Published: October 2020

Professor Ying-Chieh Lee is based at the Department of Materials Engineering, National Pingtung University of Science and Technology, Taiwan, along with a team of researchers, he is currently focused on three interconnected strands of work: high-quality and low-cost silicon carbide-silica
(SiC-SiO2) ceramics substrate; application of renewable plastic composite in agricultural greenhouses; and technology of fly-ash and oyster shells recycling and reusing. At the centre of these investigations is a shared goal of reducing waste and turning it into renewable products.
The building blocks of society
Authors: Sharp Lucy
Published: October 2020

Materials research leads to innovative technologies that can help solve societal challenges and, through global collaboration, researchers are driving forward the impact of this seemingly limitless field.
BIONICO - BIOgas membrane reformer for deceNtralIzed hydrogen produCtiOn
Authors: Binotti Marco , Di Marcoberardino Gioele , Manzolini Giampaolo
Published: October 2020

Membrane reactor technology can be applied to produce hydrogen from biogas. In order to address some of the challenges with the existing membrane reactors, an innovative design has been under development since 2015. Along with collaborators at the Politecnico di Milano university and
abroad, Project Coordinator Dr Marco Binotti has been overseeing the progress of BIONICO. Officially completed in late 2019 BIONICO set out to demonstrate a new membrane reactor concept for converting biogas into hydrogen in a real biogas plant. The novel design the BIONICO team introduced
meant that hydrogen production and separation could be completed in a single vessel. A big innovation that would improve efficiency and production capacity.
Overall focus on research, including – Fusion of measurement and numerical analysis using weak flame phenomenon in micro combustion system
Authors: Maruta Kaoru , Nakamura Hisashi , Morii Youhi , Tezuka Takuya
Published: October 2020

To achieve highly efficient internal combustion engines, it is essential that the fuel and air mixtures in cylinder burn rapidly without making undesired 'knocking' phenomena. Fuel reactions should be fast enough for attaining sufficiently fast exothermic combustion for power output
but simultaneously, it should be durable to the undesired knocking, he notes. It is essential to clarify both ignition-related fuel reactivity and combustion processes that are governed by flame dynamics under intense turbulence. Obtained knowledge should be used for designing combustion phenomena.
Dr Karou Maruta from the Institute of Fluid Science at Tohoku University is an expert in flame dynamics. Maruta and his team have been conducting a wide range of practical and theoretical experiments of weak flames in MFR ultimately for practical engine applications. They are looking to address
the modelling capabilities of complex chemical reactions. In order to achieve this, the team is attempting to develop high fidelity chemical reaction kinetics, as well as intelligent computational methods.
Character model identification and interactive AI simulation application
Authors: Lin Pei-Chun
Published: October 2020

AI is the theory and development of computer systems that can operate and perform functions which would normally require human input, such as visual perception, speech recognition, and translating one language into another. Dr Pei-Chun Lin is a researcher based in the Department of
Information Engineering and Computer Science at Feng Chia University in Taiwan. She is collaborating with other academics around the world to develop a robot that incorporates AI and will act in a way that suggests it is a thinking and feeling robot which humans can relate to. The character
model identification is especially important for creating an AI robot. The team applied data analysis tools to confirm the model and incorporate fuzzy logic, which holds significant promise for the field of AI application. Lin believes that there is a great deal of potential for AI robots
to improve the lives of people around the world.
Быстродействующие фотодетекторы оптического диапазона 950-1100 nm на основе In-=SUB=-0.4-=/SUB=-Ga-=SUB=-0.6-=/SUB=-As/GaAs-наноструктур квантовая яма-точки
Authors: Минтаиров С.А. , Гаджиев И.М. , Калюжный Н.А. , Максимов М.В. , Надточий А.М. , Нахимович М.В. , Салий Р.А. , Шварц М.З. , Жуков А.Е.
Published: October 2020

Исследованы быстродействующие фотодетекторы на основе InGaAs/GaAs-наноструктур квантовая яма-точки (КЯТ) с фронтальным и торцевым вводом излучения. Фотодетектор с 40 рядами КЯТ продемонстрировал спектральную чувствительность до 0.4 A/W в диапазоне 900-1100 nm при смещении -5 V. Постоянная времени спада импульсного отклика фотодетектора площадью 1.4·10-4 cm2 составила ~250 ps. Ключевые слова: фотодетектор, быстродействие, спектральная чувствительность, наноструктуры, емкость.
Термодесорбционный спектрометр труднолетучих активных органических соединений
Authors: Исхакова С.С. , Хасанов У. , Расулев У.Х. , Усманов Д.Т.
Published: October 2020

The paper presents the results of the development of a new type of gas analytical device for the detection of hard-volatile active organic compounds - drugs, psychotropic drugs and their metabolites, environmental pollutants. It is based on the principle of thermal desorption in combination with surface ionization of the analyte molecules under study. In studies on the detection of trace amounts (from 0.1 ng) in sample extracts, the identification of the analyte is carried out by comparing the thermal desorption spectra and determining their number of the calibration curves of the reference samples available in the electronic database of the spectrometer.
Экспериментальное исследование влияния добавки наночастиц оксида кремния на характеристики смачиваемости нефтью горной породы
Authors: Минаков А.В. , Пряжников М.И. , Сулемана Я.Н. , Мешкова В.Д.
Published: October 2020

The results of experimental studies of interfacial tension and surface wettability in the nanoscale suspension/oil/rock system were presented. For the first time, the influence of the concentration and size of silicon oxide nanoparticles on the interfacial tension coefficient and the wetting angle was systematically studied. Wide ranges of nanoparticle mass concentrations(from 0 to 1wt.%)and their average sizes(from 5 to 50 nm) were considered. It is established that the use of nanosuspensions allows to radically change the wettability of rock with oil. This effect is significantly dependent on the concentration and size of nanoparticles.
Медленные электромагнитные волны в левой среде на основе магнитоактивного плазменного метаматериала
Authors: Богомолова А.В. , Гришин С.В. , Шараевский Ю.П.
Published: October 2020

The paper presents the theoretical study results of the control of the spectrum of slow electromagnetic waves (EMWs) existing in a “left-handed” medium based on a magnetically active plasma metamaterial. The investigated metamaterial is a strip waveguide completely filled with a longitudinally magnetized “cold” electron plasma, containing a periodic structure of perfectly conducting split-ring resonators (SRRs). It is shown that either one (ordinary), either two (ordinary and unordinary) slow EMWs can exist in a “left-handed” medium based on the magnetically active plasma and the spectrum of these waves depends on the SRR own frequency and magnetic induction. The unordinary slow EMW possesses by the negative dispersion and the dispersion characteristic of the ordinary EMW has the sections with both the negative and positive dispersions.
Эффект насыщающегося поглотителя в длинноволновых вертикально-излучающих лазерах, реализованных по технологии спекания
Authors: Блохин С.А. , Бобров М.А. , Блохин А.А. , Васильев А.П. , Кузьменков А.Г. , Малеев Н.А. , Рочас С.С. , Гладышев А.Г. , Бабичев А.В. , Новиков И.И. , Карачинский Л.Я. , Денисов Д.В. , Воропаев К.O. , Ионов А.С. , Егоров А.Ю. , Устинов В.М.
Published: October 2020

Vertical-cavity surface-emitting lasers emitting at the spectral range of 1.55 µm based on heterostructures with a buried tunnel junction (BTJ) with a height step of 15 nm are studied. The devices are realized using wafer fusion technique of heterostructures grown by molecular beam epitaxy and demonstrate a single-mode lasing regime at the 8 μm BTJ-diameter. With a decrease in the BTJ-diameter, a sharp increase in the threshold current, accompanied by an abrupt increase in the output optical power and resonance frequency at the lasing threshold are observed. Stable single-mode lasing is due to the smoothing of the boundary of the overgrown surface relief, which leads to a smooth change in the profile of the effective refractive index in the lateral direction, while maintaining effective current confinement, which makes it possible to significantly reduce the transverse optical confinement factor for high-order modes even at large BTJ-diameter. However, at small BTJ-diameter, it also leads to the formation of a saturable absorber in the non-pumped parts of the active region.
Engagement Features in Physical Activity Smartphone Apps: Focus Group Study With Sedentary People
Authors: D'Addario Marco , Baretta Dario , Zanatta Francesco , Greco Andrea , Steca Patrizia
Published: October 2020

Background

Engagement with physical activity mobile apps has been reported to be a core precondition for their effectiveness in digital behavior change interventions. However, to date, little attention has been paid to understanding the perspectives, needs, expectations, and experiences of potential users with physical activity mobile apps.

Objective

The aim of this study was to investigate the features that are judged to be important for engagement with a physical activity mobile app and the reasons for their importance.

Methods

A qualitative focus-group methodology with elements of co-design was adopted in this study. Participants reporting sedentary lifestyles and willingness to improve their physical activity behavior through mobile technology were recruited. The focus group sessions consisted of 13 participants (8 men and 5 women, mean [SD] age 41.9 [7.1] years). Two researchers conducted the data analysis independently by using the inductive thematic approach.

Results

Four main themes emerged in relation to the research question and were named as follows: “physical activity participation motives,” “autonomy and self-regulation,” “need for relatedness,” and “smart.” Additionally, 2 subthemes originated from “physical activity participation motives” (ie, “medical guidance” and “weight loss and fitness for health”) and “smart” (ie, “action planning” and “adaptable and tailored”).

Conclusions

Features enhancing autonomy and self-regulation and positively affecting health and physical well-being as well as the need for relatedness, adaptability, and flexibility should be considered as core elements in the engagement of potential users with physical activity mobile apps. The emerged findings may orient future research and interventions aiming to foster engagement of potential users with physical activity apps.
SUSTAINIBILITY OF INDONESIA TRADEMARK LAW AS UMBRELLA LAW IN RESOLVING DOMAIN NAMES DISPUTE IN INDONESIA
Authors: Ningsih Ayup Suran
Published: October 2020

AbstractProtection regarding intellectual property in domain names becomes an important thing that must be considered by the domain name’s holder or user. Domain names are by character quite similar to trademarks since they serve as source indicators. This article is written to analyse the Suitability of Indonesia Trademarks Law as Umbrella Law in Resolving Domain Names Dispute in Indonesia. The methodology used in writing this article is normative legal research. Through the comprehensive discussion, it can be concluded that Indonesia trademark law is not suitable to resolve domain name dispute in Indonesia. A domain name is different from a mark based on Indonesia Trademark Law.  IntisariPerlindungan terkait kekayaan intelektual dalam nama domain menjadi hal penting yang harus dipertimbangkan oleh pemegang atau pengguna nama domain. Nama domain secara karakter sangat mirip dengan merek dagang karena mereka berfungsi sebagai indikator sumber. Artikel ini bertujuan untuk menganalisis Kesesuaian Hukum Merek Dagang Indonesia sebagai Hukum Payung dalam Menyelesaikan Sengketa Nama Domain di Indonesia. Metodologi yang digunakan dalam penulisan artikel ini adalah penelitian hukum normatif. Melalui pembahasan yang komprehensif dapat disimpulkan bahwa hukum merek dagang Indonesia tidak cocok untuk menyelesaikan perselisihan nama domain di Indonesia. Nama domain berbeda dengan tanda yang diatur pada UU Merek Dagang Indonesia.
KONSEP HAK UNTUK DILUPAKAN SEBAGAI PEMENUHAN HAK KORBAN REVENGE PORN BERDASARKAN PASAL 26 UNDANG-UNDANG INFORMASI DAN TRANSAKSI ELEKTRONIK
Authors: Christianto Hwian
Published: October 2020

AbstractRevenge porn victims experience prolonged and severe mental suffering due to defamation and negative stigma. Article 26.1 of Information and Electronic Transaction Act arranged a mechanism that victims shall request to the internet service provider to block or eliminate an information or content through a court decision. Juridical-normative research method was used through laws and regulations understandings related to victims’ rights complemented with understanding the form of victims as predisposed victims and participating victims. As a result, the right to be forgotten is a part of human rights as recognition of oneself as a victim, so that the elimination of violating electronic information that is detrimental to the victim becomes the fulfillment mechanism. IntisariKorban revenge porn mengalami penderitaan mental yang berkepanjangan dan berat akibat pencemaran nama baik dan stigma negatif. Pasal 26 ayat (1) Undang-Undang Informasi dan Transaksi Elektronik mengatur mekanisme korban harus memohon kepada penyedia jasa internet untuk memblokir atau menghapus informasi melalui penetapan pengadilan. Metode penelitian yuridis normatif digunakan melalui pemahaman peraturan perundang-undangan terkait hak korban dilengkapi pemahaman bentuk korban sebagai predisposed victims dan participating victims. Hasilnya, hak untuk dilupakan merupakan bagian dari hak asasi manusia sebagai pengakuan diri sebagai korban sehingga penghapusan informasi elektronik yang melanggar yang merugikan korban menjadi mekanisme pemenuhanya.
BUSINESS JUDGEMENT RULE: KETENTUAN DAN PELAKSANAANNYA OLEH PENGADILAN DI INGGRIS, KANADA DAN INDONESIA
Authors: Rissy Yafet Yosafet Wilben
Published: October 2020

AbstractThis article discusses the provisions of business judgment rule (BJR) in the company law and the application of BJR by the courts in the United Kingdom (UK), Canada and Indonesia. In the UK and Canada, the courts have been long examined the appropriateness of directors’ business decisions. Later, BJR was codified into the Canadian Business Corporations Act 2019, meanwhile, duty of care and fiduciary duties were codified into the UK 2006 Companies Law which implicitly regulates BJR. Indonesia adopts BJR in the Company Act 2007 but the courts rarely examine directors’ business decisions and the adoption needs to be rearranged systematically.IntisariArtikel ini membahas bagaimana dan kapan pengadilan menguji aturan penilaian bisnis (APS) dan bagaimana APS diatur dalam hukum perusahaan di Inggris Raya, Kanada, dan Indonesia. Pada pengadilan Inggris dan Kanada yang menganut tradisi hukum kebiasaan, APS telah lama diterapkan untuk menilai keputusan bisnis direktur. Baru-baru ini, APS dikodifikasikan ke dalam Undang-Undang Perusahaan Bisnis 2019. Sementara itu, tugas direktur untuk peduli dan tugas fidusia juga dikodifikasikan ke dalam Undang-Undang Perusahaan Inggris 2006 yang secara implisit mengatur APS. Indonesia juga mengadopsi APS dalam Undang-Undang PT 2007 tetapi pengadilan jarang menguji keputusan bisnis direktur dan adopsi ini perlu diatur ulang secara lebih sistematis.
Systematic Review and Meta-Analysis of Native Kidney Biopsy Complications
Authors: Poggio Emilio D. , McClelland Robyn L. , Blank Kristina N. , Hansen Spencer , Bansal Shweta , Bomback Andrew S. , Canetta Pietro A. , Khairallah Pascale , Kiryluk Krzysztof , Lecker Stewart H. , McMahon Gearoid M. , Palevsky Paul M. , Parikh Samir , Rosas Sylvia E. , Tuttle Katherine , Vazquez Miguel A. , Vijayan Anitha , Rovin Brad H. ,   for the Kidney Precision Medicine Project
Published: October 2020

Background and objectives

Native kidney biopsies are commonly performed in the diagnosis of acute kidney diseases and CKD. Because of the invasive nature of the procedure, bleeding-related complications are not uncommon. The National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases–sponsored Kidney Precision Medicine Project requires that all participants undergo a kidney biopsy; therefore, the objective of this analysis was to study complication rates of native kidney biopsies performed using automated devices under kidney imaging.

Design, setting, participants, & measurements

This is a systematic review and meta-analysis of the literature published from January 1983 to March 2018. The initial PubMed search yielded 1139 manuscripts. Using predetermined selection criteria, 87 manuscripts were included in the final analysis. A random effects meta-analysis for proportions was used to obtain combined estimates of complication rates. Freeman–Tukey double-arcsine transformations were used to stabilize variance as complications were rare.

Results

A total of 118,064 biopsies were included in this study. Patient age ranged from 30 to 79 years, and 45% of patients were women. On the basis of our meta-analysis, pain at the site of biopsy is estimated to occur in 4.3% of biopsied patients, hematomas are estimated to occur in 11%, macroscopic hematuria is estimated to occur in 3.5%, bleeding requiring blood transfusions is estimated to occur in 1.6%, and interventions to stop bleeding are estimated to occur in only 0.3%. Death attributed to native kidney biopsy was a rare event, occurring only in an estimated 0.06% of all biopsies but only 0.03% of outpatient biopsies. Complication rates were higher in hospitalized patients and in those with acute kidney disease. The reported complications varied on the basis of study type and geographic location.

Conclusions

Although the native kidney biopsy is an invasive diagnostic procedure, the rates of bleeding complications are low. Albeit rare, death can occur postbiopsy. Complications are more frequently seen after kidney biopsies of hospitalized patients with AKI.
Mathematical analysis of influence of ultrasonic stabilization of residual stresses in round plate details
Authors: Baltaev Timur A. , Bayakhov Alibi N. , Bektilevov Aldabergen Yu. , Khamzina Bayan E. , Dzhusupkalieva Roza I.
Published: October 2020

The most important task of precision engineering at the present stage is the development of more efficient technological processes for manufacturing parts that ensure not only high accuracy at a minimum cost, but also the preservation of the original accuracy indicators throughout the entire service life of the product. (Research purpose) The research purpose is in studying the technological operation of stabilization of residual stresses of a round plate based on the method of relaxation of residual stresses by the influence of oscillatory movements of ultrasonic frequency. (Materials and methods) The article notes that the parts and components of the sensors are connected to each other, mainly by means of screws and other threaded connections; the abundance of springs (of return type), internal backlashes of mobile mechanisms, contributes to the occurrence of residual stresses (shrinkage, lapping), which affects the stability of the readings. Authors proposed a method and performed mathematical modeling of ultrasonic stabilization of the deformation of a round plate (elastic sensing element), having previously provided tension by the influence of an external load on its surface. Authors have found that this technology provides high performance and is not difficult to implement from a technical point of view. (Results and discussion) It was found by mathematical analysis that the processing time depends inversely on the vibration frequency of the plate, so processing the plate with an ultrasonic frequency significantly reduces the required processing time, increases its performance compared to traditional methods of training. (Сonclusions) With a small amplitude of these vibrations, the energy of a single oscillation cycle decreases, and this significantly reduces the amount of accumulated deformation, which improves the quality of processing.
Operation efficiency of knitters knives of domestic and import production used in agricultural machines
Authors: Ivanov Valeriy I. , Aulov Vyacheslav F. , Rozhkov Yuriy N.
Published: October 2020

Utilization of various stalks of grain crops (wheat, soy and rapeseed) is made by their grinding, usually in the field. The crushed straw is scattered across the field, and the spreading width is adjusted depending on the width of the reaper cutting devices. (Research purpose) The research purpose is in analyzing the existing market of knives for agricultural machines; goods of enterprises producing the knives, harvesters, using knives, types of knives, part numbers, specifications of knives in size and durability and to produce a feasibility study of using hardening knives. (Materials and methods) Authors used a digital method of searching through the Internet for enterprises that produce knives; combines that use knives; types of knives and their characteristics. (Results and discussion) It was found that due to intensive wear, the geometry of the cutting part and the overall dimensions of the working bodies of harvesting machines change, which causes violations of agricultural requirements, increased losses during crop harvesting, and increased energy costs. It was found that the efficiency of an agricultural machine directly depends on the state of its working parts, since they are limiting in terms of durability. The article notes that replacement of worn elements is accompanied by more labor, which reduces labor productivity, unnecessary equipment downtime and ultimately reduce profits of the enterprise. These factors indicate the need for technological measures to increase the resource of working parts of cutting devices of agricultural machines. (Conclusions) The article presents the results of the analysis of the market of existing enterprises for the production of knives. It gaves a feasibility to study of the effectiveness of strengthening knives using the technology of the Federal scientific Agroengineering center VIM. Production of hardened knives gives a good economic effect on import substitution.
State support for agriculture of Russia and regions: historical aspect and modern realities
Authors: Iovlev Gregoriy A. , Shaykhutdinov Farit R. , Goldina Irina I.
Published: October 2020

This research is conducted under the «Development of the conditional factors and requirements standards for methods of use conditition coefficients for the transfer of tractors, grain and corroboration combines to the reference units in determining the standards to their needs» proposed by the Department of Science and Technology Policy and Education of the Ministry of Agriculture of the Russian Federation for Agricultural Universities. (Research of purpose) The research purpose is in assessing the current state of state support for agriculture in Russia and the regions, conducting a comparative analysis of methods and directions of state support for agricultural production in the USSR and the current level of state support for agriculture in developed foreign countries. (Materials and methods) The research materials were studies of domestic scientists, Government Resolutions of the Russian Federation and the Sverdlovsk region, laws of the Sverdlovsk region, and official statistical indicators. Used methods: abstract-logical, monographic, economic-statistical, forecasting method, economic-mathematical modeling, expert assessments, and others. (Results and discussion). The article presents an algorithm for implementing state support for agriculture in the USSR, in the first years of the post-soviet period, analyzes the volume of state support and production in leading foreign countries, analyzes state support and production volumes of agriculture in the Sverdlovsk region and calculates indicators that characterize the effectiveness of state support. (Conclusions) Analysis of the use of state support, the use of economic and statistical method, expert evaluations, the proposed formulas for calculation of indicators characterizing the efficiency of state support have helped to make recommendations for optimization of volumes and directions of state support for regions and for the whole of agriculture of Russia.
Regional measures of state support for increasing the technical equipment of machine and tractor fleet of agricultural enterprises
Authors: Gabitov l’dar I. , Mudarisov Salavat G. , Iofinov Pavel A.
Published: October 2020

The article analysis the dynamics of the technical equipment of the machine and tractor fleet of agricultural enterprises of the Republic of Bashkortostan. Authors analyzed the regional programs implemented in the Republic to support agro-industrial enterprises. The article proves the effectiveness of allocating subsidies for the organization of capital repairs and modernization of equipment in operation on the basis of specialized repair enterprises of the Republic. (Research purpose) The research purpose is in determining the effectiveness of regional state support measures aimed at improving the level of technical equipment of agricultural enterprises. (Materials and methods) The article shows the importance of using a scientifically based system of machines for the implementation of innovative technologies for the cultivation of major agricultural crops and production of livestock products in various soil and climatic conditions of the Republic of Bashkortostan. (Results and discussion) The article notes that the implementation of regional programs of support of agricultural enterprises in the Republic of Bashkortostan has increased the volume of works on repair of agricultural machinery repair shops up to 7 times, reduce the average aging of tractors and combines for the last 10 years (2010-2020) by 18 percent, increase the number of equipment above the standard lifetime of 34 percent. (Conclusions) To achieve the standard indicators of technical equipment of agricultural enterprises, it is necessary to increase their energy supply to 230-250 horsepower per 100 hectares of sown area, which will require the additional purchase of at least 1200 harvesters, more than 3000 tractors of various classes and 250 forage harvesters.
Device for checking crankshaft bending and its straightening
Authors: Tabakov Petr A. , Tabakov Aleksey P.
Published: October 2020

Before grinding, the crankshafts are checked for curvature, the allowed runout of the average root neck should be within 0.03-0.05 mm. Straightening is performed on a hydraulic press, installing the crankshaft on prisms in the side root necks, and to check the degree of straightening, one have to move the crankshaft to the grinding machine and fix it on the centers. Such devices have many disadvantages. (Research purpose) The research purpose is in expanding the functionality of the crankshaft straightening device, developing drawings and application of a patent for a device that could check the bending of the crankshaft at the centers, as well as straightening with a fixed reverse bend, which eliminates multiple straightening and increases the life of the shaft and the resource of the internal combustion engine. (Materials and methods) The article proposes upgraded equipment, protected by a patent, to increase the life of the crankshaft, labor productivity by 3-4 times and the accuracity of straightening. (Results and discussion) Authors have made drawings and got patent N191590 from August 14, 2019 for a device for checking the bending of the shaft on the centers and straightening under the press. The article describes the equipment work. (Conclusions) Checking the crankshaft for bending at the centers and straightening with a fixed reverse bend on a single device significantly improves labor productivity and straightening accuracy. The straightening of crankshafts by the proposed method is more than 99 percent without breakdowns.
Análise bibliométrica sobre o uso da CFD em vortex tube no período entre 2000 e 2020
Authors: Modesto Danillo Lanzieri , Cekinski Efraim
Published: October 2020

O objetivo deste trabalho é verificar o volume de produção científica, dentro do tópico de engenharia nos últimos vinte anos, as abordagens acerca do tubo de vórtice de Ranque-Hilsch simulado por meio da fluidodinâmica computacional (CFD). Foi aplicado como metodologia a Lei de Bradford para análise de produtividade com um sequenciamento progressivo dos resultados obtidos, constando desde a definição de uma base de coleções de periódicos para avaliar qual é a que apresenta o maior volume de publicações a respeito do tema proposto até na investigação mais profunda para encontrar o material mais citado, quais autores têm apresentado maior contribuição no meio e também quais foram os mais citados dentro desta base de coleção. Com isto, foi possível constatar que a combinação mais utilizada, que são “vortex tube” e “CFD”, possui uma média de 1,35 publicações por ano e ainda evidencia uma diminuição na quantidade de publicações desde 2016.
Luz, câmera e (re)ação
Authors: Massmann Débora Raquel Hettwer , Salles Atílio Catosso , De Lima Cesar Augusto
Published: October 2020

Esta pesquisa tem como objetivo compreender como se dá o processo de constituição da narratividade cinematográfica no filme Meteororango Kid – o herói intergalático e sua relação com o contexto histórico em que foi produzido, no caso, a Ditadura Civil Militar Brasileira (1964-1985). Construiremos um estudo do período da Ditadura Militar Brasileira a partir do “Cinema Marginal”. Buscaremos também contribuir para um debate sobre a Ditadura Civil Militar e o uso do cinema como fonte histórica, uma vez que é algo recente na historiografia.
O uso do WhatsApp nas eleições de 2018 e as lacunas teóricas da Justiça Eleitoral
Authors: Alonso Panho Isabella , Dourado Bastos Manoel , Fernandes Silva Gabriela
Published: October 2020

O uso dos disparos massivos de mensagens pelo WhatsaApp nas últimas eleições presidenciais passou a ser objeto de olhares mais críticos a partir de uma reportagem publicada na Folha de S. Paulo em outubro de 2018. Com as denúncias veiculadas jornalisticamente, várias ações judiciais foram protocolizadas junto ao TSE (Tribunal Superior Eleitoral), que firmou, na época, o entendimento de que se tratava de comunicação espontânea do eleitorado – o que inviabilizou, naquele momento, o aprofundamento das investigações. Partindo desse objeto, a proposta deste artigo é analisar tanto as posições adotadas pelo TSE como o respaldo legal que as embasa através das lentes dos conceitos da (Crítica da) Economia Política da Comunicação. Fundamentando-se, primordialmente, no aparato teórico tecido por Bolaño e por Smythe, é possível caracterizar e identificar a circulação de mercadoria audiência nas eleições de 2018, desconstituindo-se a posição do TSE através da identificação dessa falha teórica.
Entrevista pingue-pongue
Authors: Bueno Thaisa Cristina
Published: October 2020

Este artigo propõe uma catalogação didático-pedagógica de tipos de entrevista pingue-pongue usual no jornalismo escrito nacional com o intuito de sistematizar alguns modelos de textos possíveis e suas variações. A pesquisa vem sanar uma lacuna no debate sobre entrevista escrita, visto que boa parte da literatura que discute o tema na área, em língua portuguesa, dedica-se a tratar, mais pontualmente, das orientações de execução e das condições de produção – Erbolato (1991), Lage (2003), Pereira Júnior (2006), Oyama (2009), Floresta e Brslauskas (2009) e Nascimento (2009), Pinto (2009), Medina (1995) etc. Trata-se de um exercício didático de base descritiva, com amostras por intencionalidade, cujo material do campo foi identificado e captado durante dez semestres (2013, 2014, 2016, 2017 e  2018) em que a pesquisadora atuou como responsável pela disciplina de Gêneros Jornalísticos. A pesquisa também estrutura uma revisão de literatura sobre o assunto.
Balizas do campo comunicação e política
Authors: Weber Maria Helena
Published: October 2020

O cabimento desse texto está relacionado à reflexão sobre aspectos que permitem identificar a consolidação do Campo da Comunicação e Política como um espaço interdisciplinar e substantivo à compreensão de fenômenos sociais, culturais, políticos e econômicos engendrados no trígono Estado, Mídia e Sociedade. Nessas três dimensões de poder podem ser identificados processos de comunicação e coerção singulares relacionados à visibilidade e credibilidade. O texto privilegia então a comunicação institucional, a comunicação societal, a comunicação midiática, a comunicação pública e aspectos históricos. O texto apresenta aspectos da complexidade teórica e metodológica de um campo que abrange regimes políticos, mídias, sistemas e produtos de comunicação, assim como a sua constituição no Brasil.
Robótica en cirugía y neurocirugía, aplicaciones y desafíos, una revisión
Authors: Vargas Rosero Hermes Fabian , Vivas Albán Oscar Andrés
Published: October 2020

La integración de robots en los quirófanos plantea mejorar el desempeño y eficiencia de variados procedimientos, dado que ofrece ventajas destacables sobre los procedimientos convencionales, en particular la precisión, el filtrado de temblor de mano y la posibilidad de ejecución de tareas complejas, sin embargo, aún prevalecen considerables desafíos que afectan la masificación y la maniobrabilidad por parte de los cirujanos. En el presente trabajo se realiza una revisión del estado actual de la cirugía robótica, los retos y las tendencias. En concreto se evidencia la necesidad de mecanismos de realimentación de fuerza óptimos, así como la visualización dinámica mediante realidad aumentada o realidad virtual. Aun no es posible determinar que la cirugía robótica ha alcanzado estándares, sin embargo, la integración de tecnologías alternas permitirá mejorar no solo la eficiencia en cuanto al robot sino respecto de su operación por parte de los cirujanos.
White-box flight simulator built with system dynamics to support urban transportation decision-making and address induced travel demand
Authors: Angarita Zapata Juan Sebastian , Andrade Sosa Hugo Hernando , Masegosa Arredondo Antonio David
Published: October 2020

Induced Travel Demand is a phenomenon (ITD) wherein building new road infrastructure increases private car use. ITD has been measured and corroborated through econometric models that give an account of how much travel demand can be induced after road construction. The latter without claims of causality in their inner structure (black-box approach). Beyond the contributions of black-box models, it is still needed to explain structurally ITD for understanding and identifying its causes. Thus, this approach allows policy-makers to design comprehensive policies to deal with ITD in urban context wherein new roads are still needed to guarantee connectivity. In this paper, we present a white-box flight simulator based on a System Dynamics model to support urban transportation decision-making and address ITD. Through the simulator developed, it is possible to improve the causal understanding of ITD. Besides, although the considered policies to intervene in this phenomenon have a conceptual connotation, the simulator is a means to acquire knowledge of structural complexity underlying the interaction between the policies and ITD.
Despacho económico multiperiodo con restricciones de seguridad usando los factores de sensibilidad PTDF y LODF
Authors: Marin Cristian Camilo , López Lezama Jesús María , Sierra Aguilar Juan Esteban , Jaramillo Duque Alvaro
Published: October 2020

El problema de despacho económico multiperiodo (DEM) consiste en determinar de manera óptima que unidades de generación deben suministrar potencia al sistema en un horizonte de tiempo típico de 24 horas. El DEM con restricciones de seguridad (SCUC por sus siglas en inglés) es un problema de alto costo computacional debido a la cantidad y naturaleza de las variables involucradas. En este artículo se presenta una formulación alternativa del SCUC para reducir su costo computacional, mediante el uso de los factores de sensibilidad PTDF y LODF. En contraste con las formulaciones clásicas, el uso de estos factores permite calcular flujos de carga  sin necesidad de utilizar los ángulos nodales, reduciendo el número de variables y restricciones del modelo. Además, se implementa una metodología de filtro de contingencias activas N-1 que reduce aún más la carga computacional, a través de cortes de usuario. Se presentan resultados para el sistema IEEE-RTS96 que evidencian la robustez y aplicabilidad del modelo propuesto. Se encontró que el uso de los factores de sensibilidad PTDF y LODF, en conjunto con la metodología de filtros de contingencias, reduce el costo computacional hasta en un 86% con respecto a su formulación convencional. Adicionalmente, la metodología propuesta identifica que líneas son más vulnerables debido a sobrecargas, y cuales líneas causan mayores impactos al sistema cuando fallan.