bluuebunny/crossref_metadata_2025 huggingface dataset:
SLP-educator classroom collaboration: A review to inform reason-based practice
Authors: Archibald Lisa MD
Published: January 2017

Background and aims

Increasingly, speech language pathologists are engaging in collaborative classroom services with teachers and other educators to support children with developmental language disorder and other communication impairments. Recent systematic reviews have provided a summary of only a small fraction of the available evidence and recommended the use of reason-based practice in the absence of a sufficient empirically driven evidence base. The purpose of this paper was to provide a broad (but critical) review of the existing evidence.

Main contribution

Papers were gathered through review of reference lists in the recent systematic reviews and other published works, as well as general internet searches. A total of 49 papers were identified either reporting empirical evidence pertaining to SLP-educator collaborative classroom activities, empirical evidence pertaining to consultative services, classroom instruction, or small group intervention in the classroom, or providing information, discussion, surveys, or reviews related to the topic. Evidence pertaining to vocabulary, oral language, phonological awareness, curriculum-based language, and written language were summarized together with qualifications based on elements of the research design.

Conclusion and implications

Although much of the evidence must be interpreted with considerable caution, the present review is informative for clinicians looking to adopt a reason-based approach to practice.
Tolerogenic interactions between CD8+ dendritic cells and NKT cells prevent rejection of bone marrow and organ grafts
Authors: Hongo David , Tang Xiaobin , Zhang Xiangyue , Engleman Edgar G. , Strober Samuel
Published: January 2017

Key Points

Tolerance after bone marrow transplantation requires CD8+ DCs and NKT-cell interaction. CD8+ DCs and NKT cells become tolerogenic after conditioning with total lymphoid irradiation.
Lymphangiogenesis is a feature of acute GVHD, and VEGFR-3 inhibition protects against experimental GVHD
Authors: Mertlitz Sarah , Shi Yu , Kalupa Martina , Grötzinger Carsten , Mengwasser Jörg , Riesner Katarina , Cordes Steffen , Elezkurtaj Sefer , Penack Olaf
Published: January 2017

Key Points

aGVHD after hematopoietic stem cell transplantation is associated with lymphangiogenesis in the intestinal tract and lymph nodes. Inhibition of lymphangiogenesis by antibodies against VEGFR-3 ameliorated aGVHD.
Tissue is the issue and tissue competition. Re‐biopsy for mutation T790: where and why?
Authors: Zarogoulidis Paul , Gaga Mina , Huang Haidong , Darwiche Kaid , Rapti Aggeliki , Hohenforst‐Schmidt Wolfgang
Published: January 2017

Lung cancer is still the leading cause of death among all cancers. During the last 15 years, pharmacogenomics of lung cancer have established targeted therapy with tyrosine kinase inhibitors (TKIs) for epidermal growth factor receptor (EGFR) positive patients in adenocarcinoma or mixed adenosquamus lung cancer patients. However; while novel drugs are released in the market, at the same time novel mutations are observed after tyrosine kinase inhibitor administration. Recently the novel mutation T790 was observed and is highly prevalent in patients already treated with a TKI. A new drug targeting this mutation is already on the market, however; the most important factor for successful treatment in these patients, is adequate tissue re‐sampling so that novel mutations can be detected.
Silence as Resistance in Pat Barker’s Regeneration and Assia Djebar’s Children of the New World
Authors: Reeds Eleanor
Published: January 2017

This essay reads the hidden histories of the First World War and the Algerian War of Independence in Pat Barker’s Regeneration and Assia Djebar’s Children of the New World, focusing on their representation of a feminized resistance to war that takes silence as its most powerful weapon. In contrast to the privileging of bearing witness in post-Holocaust theories of language and suffering, this essay argues that Barker and Djebar ultimately suggest that, in the face of war’s atrocities, not speaking is an equally valuable act.
JunB regulates angiogenesis and neurovascular parallel alignment in mouse embryonic skin
Authors: Yoshitomi Yasuo , Ikeda Takayuki , Saito Hidehito , Yoshitake Yoshino , Ishigaki Yasuhito , Hatta Toshihisa , Kato Nobuo , Yonekura Hideto
Published: January 2017

Blood vessels and nerve fibers are often closely arranged in parallel throughout the body. Therefore, neurovascular interactions have been suggested to be important for the development of vascular networks. However, the molecular mechanisms and genes regulating this process remain unclear. In the present study, we investigated the genes that are activated in endothelial cells (ECs) following interactions with neurons during vascular development. Microarray analyses of human primary microvascular ECs co-cultured with mouse primary dorsal root ganglion cells showed that JunB is strongly upregulated in ECs by neurovascular interactions. Furthermore, the forced expression of JunB in ECs stimulated a tip-like cell formation and angiogenesis in vitro and induced vascular endothelial growth factor A (VEGFA) and the pro-angiogenic integrin subunit ITGB3 expression. Moreover, in vivo knockdown of JunB in ECs from developing mouse limb skin considerably decreased the parallel alignments of blood vessels and nerve fibers. Taken together, the present data demonstrates for the first time that JunB plays an important role in the formation of embryonic vascular networks. These results contribute to the molecular understanding of neurovascular interactions during embryonic vascular development.
A statistical approach to understanding reproductive isolation in two sympatric species of tree crickets
Authors: Bhattacharya Monisha , Isvaran Kavita , Balakrishnan Rohini
Published: January 2017

In acoustically communicating animals, reproductive isolation between sympatric species is usually maintained through species-specific calls. This requires that the receiver be tuned to the conspecific signal. Mapping the response space of the receiver onto the signal space of the conspecific investigates this tuning. A combinatorial approach to investigating the response space is more informative as the influence on the receiver of the interactions between the features is also elucidated. However most studies have examined individual preference functions rather than the multivariate response space. We studied the maintenance of reproductive isolation between two sympatric tree cricket species (Oecanthus henryi and Oecanthus indicus) through the temporal features of the calls. Individual response functions were determined experimentally for O. henryi, the results from which were combined in a statistical framework to generate a multivariate quantitative receiver response space. The predicted response was higher for the signals of the conspecific than for signals of the sympatric heterospecific, indicating maintenance of reproductive isolation through songs. The model moreover allows prediction of response to untested combinations of temporal features as well as delineation of the evolutionary constraints on the signal space. The model can also be used to predict the response of O. henryi to other heterospecific signals, making it a useful tool for the study of the evolution and maintenance of reproductive isolation via long-range acoustic signals.
Lombard effect onset times reveal the speed of vocal plasticity in a songbird
Authors: Hardman Samuel I. , Zollinger Sue Anne , Koselj Klemen , Leitner Stefan , Marshall Rupert C. , Brumm Henrik
Published: January 2017

Animals that use vocal signals to communicate often compensate for interference and masking from background noise by raising the amplitude of their vocalisations. This response has been termed the Lombard effect. However, despite more than a century of research little is known how quickly animals can adjust the amplitude of their vocalisations after the onset of noise. The ability to respond quickly to increases in noise levels would allow animals to avoid signal masking and ensure their calls continue to be heard, even if they are interrupted by sudden bursts of high amplitude noise. We tested how quickly singing male canaries (Serinus canaria) exhibit the Lombard effect by exposing them to short playbacks of white noise and measuring the speed of their responses. We show that canaries exhibit the Lombard effect in as little as 300 ms after the onset of noise and are also able to increase the amplitude of their songs mid-song and mid-phrase without pausing. Our results demonstrate high vocal plasticity in this species and suggest that birds are able to adjust the amplitude of their vocalisations very rapidly to ensure they can still be heard even during sudden changes in background noise levels.
A New Empirical Relation between the Enthalpy of Vaporization and (Tc − Tm) for the Liquids of Similar Chemical Groups (Tc: Critical Temperature, Tm: Melting Temperature)
Authors: Kanno Hitoshi
Published: January 2017

A new empirical linear relation between the enthalpy of vaporization and (Tc − Tm) (Tc: critical temperature, Tm: melting temperature) is presented for liquids of similar chemical groups. Combination of the above finding with Trouton’s rule leads to another linear relation between Tb (boiling temperature) and (Tc − Tm). As an extension, a different expression for the Guldberg rule is also derived. These findings can contribute to the understanding of general behavior of liquids and the development of theories of liquids.
The “Black Sounds” of Ene Mihkelson’s Katkuhaud (‘Plague Grave’) and W. G. Sebald’s Austerlitz. Part I. Foundations
Authors: Jaanus Maire
Published: January 2017

“Foundations” is the first part of a two-part article to be published in Interlitteraria. It gives a brief account of the post-humanistic, foundationless, and traumatic world encountered in Ene Mihkelson’s Katkuhaud (‘Plague Grave’) and W. G. Sebald’s Austerlitz, and continues with more detailed elaborations of the loss of specific foundational ideals, such as their contemporary experience of the failure and limits of language, of sense-making, and memory; the haphazardness of history; the invalidity of compensatory justice, and above all the deletion of their childhood fields of joy and love or of what Panksepp calls their “affective mind.” It prepares for a fuller comparison of Mihkelson and Sebald’s tonality, and their art of valediction and memory in Part two.
About the authors
Authors: Authors About
Published: January 2017

About the authors
The Same in Polish, or Peculiarities of Bilingual Occasional Poetry in the Eighteenth-century Grand Duchy of Lithuania
Authors: Vaškelienė Asta
Published: January 2017

The paper addresses eighteenth-century occasional poetry of Lithuania written in parallel Latin and Polish. The research seeks to draw attention to bilingual creation as a literary phenomenon that reflects the linguistic priorities and cultural needs of the time, and to reveal the most distinct semantic and artistic peculiarities of bilingual occasional poetry. As a phenomenon of Lithuanian neo-Latin literature, bilingualism has not yet been addressed in detail in scholarly historiography. Only an article by Eugenija Ulčinaitė, in which she introduces linguistic expression, semantics and stylistics of sixteenth to seventeenth-century Lithuanian bilingual texts is devoted to this thematic. Research in eighteenth-century occasional poetry of the Grand Duchy of Lithuania has shown that parallel texts occur in nearly all poetry genres, but they were most popular among epigrams. Language variants of the works can be written both by the same and by different authors. Comparative analysis of texts has shown that when the primary – Latin – content is conveyed in Polish, it can be modified or complemented with information relevant to the dedicatee. Such alteration causes semantic and stylistic differences and creates a shift in the emotional tone of a work. Despite the fact that both – Latin and Polish – versions of a work are officially dedicated to the same dedicatee, the group of recipients seems expanded. It is quite possible that the Latin version is addressed to the individual named in the title, while the Polish version is meant for the general public or people lacking in education necessary to understand the Latin text. The need to convey the same content in Polish points to the vitality of occasional literature and its universally perceived purpose.
Luigi Pirandello’s Works in Lithuania: Why the Dialogue Did Not Take Place
Authors: Vanagaitė Gitana
Published: January 2017

Luigi Pirandello (1867–1936) was an Italian modernist writer and playwright who enriched literature with questions of modern identity as it relates to the contradiction between human consciousness and reality. Pirandello pondered questions of art and reality, mask and essence, life and form, and the fragmentation of a personality. In his works, he also foresaw what would later constitute the base of existential philosophy.The reception of Pirandello’s works in Lithuania has been limited, in part because of the small number of his works translated into Lithuanian – only a dozen short stories, two plays, and a novel.The first more or less systematic and thorough introduction to the play wright and his works took place in 1934, when the Italian writer was awarded the Nobel Prize in Literature for his “bold and brilliant renovation of the drama and the stage.” A few articles on Pirandello’s creative principles appeared in the Lithuanian press. A Lithuanian poet, Kazys Binkis, translated the beginning of Pirandello’s play, Sei personaggi in cerca d’autore (Six Characters in Search of an Author, 1921), and a writer, Kostas Korsakas, edited a book consisting of five novels, Pirmoji naktis (‘First Night’). A Lithuanian translation of his novel, Il fu Mattia Pascal (The Late Mattia Pascal, 1904), and two plays, Sei personaggi in cerca d’autore and Enrico IV (Henry IV, 1922), came out during the Soviet period.All translations were accompanied by a foreword containing basic biographical details about and introducing Pirandello’s cultural, literary and creative life. Although Pirandello gets attention in Lithuanian university textbooks, no academic paper about him or his works has been published yet. There have been no translations of Pirandello’s theoretical texts, his thoughts on the cultural situation, literature, and man at the beginning of the 20th century, i.e., a volume of essays Arte e Scienza (Art and Science) written in 1908 or an important long essay, L’umorismo (On Humor), in which author also examines the principles of his own art. On the other hand, the literary reception of Pirandello’s works has been supplemented by theater performances. Five plays of his were mounted and the play, Henry IV, was twice produced on Lithuanian theater stage.The article examines why Pirandello’s artistic ideas, which reached Lithuania during the second decade of the 20th century, remained on the periphery and failed to influence the literary canon. Keywords: Luigi
Translating the Dynamics of Fictional Space: Estonian Translation of Marcel Proust’s Le Temps retrouvé
Authors: Kütt Madli
Published: January 2017

The article discusses the way that Proust’s text constructs dynamic and static elements of fictional space, and the further dynamisation or fixation of these elements by the process of translation. The focus of the study is on how movements of fictional space and characters can change in strength, direction and manner, when translated. In other words, rather than looking for that which is “lost in translation”, we are dealing with a comparison of two fictional worlds and the processes in them and between them.
UPS Optimizes Delivery Routes
Authors: Holland Chuck , Levis Jack , Nuggehalli Ranganath , Santilli Bob , Winters Jeff
Published: January 2017

UPS, the leading logistics provider in the world, and long known for its penchant for efficiency, embarked on a journey to streamline and modernize its pickup and delivery operations in 2003. This journey resulted in a suite of systems, including a meta-heuristic optimization system, which it called “On Road Integrated Optimization and Navigation” (ORION). Every day, ORION provides an optimized route for each of UPS’ 55,000 U.S. drivers based on the packages to be picked up and delivered on that day. The system creates routes that maintain the desired level of consistency from day to day. To bring this transformational system from concept to reality, UPS instituted extensive change in management practices to ensure that both users and executives would accept the system. Costing more than $295 million to build and deploy, ORION is expected to save UPS $300–$400 million annually. ORION is also contributing to the sustainability efforts of UPS by reducing its CO2 emissions by 100,000 tons annually. By providing a foundation for a new generation of advanced planning systems, ORION is transforming the pickup and delivery operations at UPS.
Technology Mergers and Acquisitions in the Presence of an Installed Base: A Strategic Analysis
Authors: Wang Qiu-Hong , Hui Kai-Lung
Published: January 2017

We study the strategic benefits of mergers and acquisitions (M&As) when competing information technology vendors sell different generations of the same product with different quality. We assume the new product arrives unexpectedly when an installed base of the old product exists. We show that the combination of consumers’ purchase history and heterogeneity leads to new demand complexity that gives rise to innovative product strategies. We find that shelving the old product is an important motivation for M&A. The acquirer may exercise static or intertemporal price discrimination depending on whether it can exercise upgrade pricing. M&A may speed up or slow down new product consumption, and it can lead to delayed new product introduction in some markets. However, it always increases the acquirer’s profit and can sometimes help maximize social welfare. We discuss relevant managerial and policy implications.

The online appendix is available at https://doi.org/10.1287/isre.2016.0659 .
Construção e validação de um índice para o planejamento da mobilidade com foco em polos geradores de viagens
Authors: De Oliveira Angelica Meireles , Rodrigues da Silva Antônio Nélson
Published: January 2017

Abordagens de planejamento destinadas a enfrentar os problemas de mobilidade associados aos grandes Polos Geradores de Viagens (PGVs) devem considerar as fases de diagnóstico, planejamento e avaliação das ações propostas. Esta é a estrutura da metodologia de sete etapas apresentada neste estudo, em que um índice de mobilidade sustentável é concebido para satisfazer necessidades locais. O objetivo deste artigo é discutir as diretrizes e procedimentos adotados para a construção e validação deste índice, estruturado em forma de um modelo hierárquico, bem como os resultados obtidos com a sua apli-cação em um campus universitário. A abordagem permitiu a identificação e avaliação dos principais fatores que afetam as condições de mobilidade do campus, além da associação destes aos diferentes modos de transporte. A importância da estra-tégia de validação foi evidenciada pela identificação de lacunas na estrutura do índice. Alguns ajustes foram então sugeridos, o que parece ser essencial para fazer do índice uma ferramenta também mais efetiva de planejamento.
Modelos matemáticos baseados no Time Dependent Vehicle Routing Problem para planejamento da logística urbana sob a ótica ambiental
Authors: Ferreira Bárbara Valente , Rosa Rodrigo De Alvarenga
Published: January 2017

Empresas que operam com logística urbana direcionam seus esforços para soluções que buscam reduções de custo, desconsiderando questões ambientais. Isso ocorre em função da crença que soluções ambientalmente corretas são mais caras. No entanto, com as crescentes preocupações ambientais, as empresas têm levado em conta os fatores ambientais buscando a responsabilidade social. Assim, este artigo apresenta dois modelos matemáticos, ambos baseados no Time Dependent Vehicle Routing Problem (TDVRP), sendo um com objetivo de avaliar a redução do tempo das rotas e o outro com objetivo avaliar a redução da emissão de poluentes. Para testar o modelo, foi realizada uma aplicação real de uma empresa de distribuição de alimentos na região metropolitana de Vitória, ES. Usou-se o CPLEX 12.6 para rodar os modelos propostos com cenários baseados em dados reais da empresa. Os resultados mostraram que a solução com viés ambiental pode ser financeiramente vantajosa para a empresa.
Identificando os desafios e as boas práticas para o transporte urbano de cargas, por meio de uma revisão bibliográfica sistemática
Authors: Oliveira Cintia Machado , D'Agosto Márcio De Almeida , Mello Ana Lúcia Dorneles de , Assumpção Fabiana Do Couto , Gonçalves Fabio Dos Santos , Gonçalves Daniel Neves Schmitz
Published: January 2017

Objetivou-se com este estudo, identificar, mediante uma revisão bibliográfica sistemática, os desafios enfrentados pelo transporte urbano de carga e as boas práticas que podem ser adotadas, visando os aspectos socioambientais. Identifica-ram-se também os agentes de implantação das boas práticas (poder público ou iniciativa privada). Como contribuição, apon-tam-se a elaboração de um procedimento de revisão bibliográfica sistemática, que foi estabelecido, exclusivamente, para este estudo e a identificação de 26 boas práticas capazes de apoiar a solução de 16 desafios do TUC. O poder público, a iniciativa privada e ambos os agentes podem solucionar 31%, 44% e 25% dos desafios, respectivamente, atuando por meio de 27%, 65% e 8% das práticas. Verificou-se que 81% das boas práticas podem contribuir positivamente, em relação aos aspectos econômicos. A pesquisa limitou-se a uma revisão bibliográfica. Recomenda-se que trabalhos futuros considerem uma pes-quisa de campo para verificar se tais desafios e boas práticas identificados fazem parte da realidade das cidades.
Dinge sammeln, Wissen schaffen
Authors: Häner Flavio
Published: January 2017

Im Übergang vom 18. ins 19. Jahrhundert etablierte sich das Sammeln von Gegenständen in der Natur von einer Freizeitbeschäftigung einzelner Privatpersonen zur wissenschaftlichen Praxis. So entwickelten Forscher neue Antworten auf naturwissenschaftliche Fragen - beispielsweise zur Beschaffenheit der Natur oder der Entwicklung der Lebewesen. In den naturwissenschaftlichen Museen konnte dieses neue Wissen mit einem breiten Publikum verhandelt und etabliert werden. Anhand der Geschichte der naturhistorischen Sammlungen in Basel vollzieht Flavio Häner nach, wie aus dieser Zeit nicht nur neue wissenschaftliche Disziplinen hervorgingen, sondern eine Gesellschaft entstand, in der Fragen über die Natur nicht mehr mit einem Verweis auf die biblische Schöpfungsgeschichte beantwortet werden konnten.
Postnazismus und Populärkultur
Authors: Jazo Jelena
Published: January 2017

Der Nationalsozialismus hat einen beispiellosen Bilderapparat hervorgebracht, der durch seine vielfachen medialen Wiederbelebungen in der visuellen Kultur der Gegenwart allgegenwärtig ist. Die unleugbare negative Faszination, die von faschistoider Ästhetik ausgeht, wird in Anbetracht der Persistenz nazistischer Ikonografie, wie sie uns in Musikvideos, Filmen oder im Internet begegnet, überdeutlich. Der Nationalsozialismus ist nicht mehr nur historische Tatsache, er ist eine Bilder-Erzählung. Entlang ausgewählter Fallbeispiele der Popkultur zeigt Jelena Jazo, wie sich der Widerhall des nazistischen Bildprogramms im Kontext der Gegenwart verstehen lässt und welche Bedeutung er für die heutige Kultur und den Umgang mit der Vergangenheit hat.
Reported cases for the development of AAC teaching materials for literacy
Authors: Kim KyungYang , Lee JungEun , Lee NaYoung , Kim JungEun , Lee JungYoon ,   Korean Society of Augmentative and Alternative Communication
Published: January 2017

Background and Objectives: The purpose of this study was to develop Augmentative and Alternative Communication (AAC) teaching materials for improving literacy education for students with disabilities. Method: AAC literacy materials familiar to children such as textbooks, fairy tales and nursery rhymes were selected. We selected a familiar story book that was small enough to be contained in a grade appropriate textbook, along with familiar nursery rhymes and fairy tales to be used for developing AAC literacy teaching materials. After the first selection of the target vocabulary was connected with, a symbol created by the AAC device was repeated to communicate to proceed with the activity, read a story or sing nursery rhymes. Results: A case study in autistic children two children all have the ability to promote literacy. Conclusion: The AAC teaching and learning materials developed to promote children’s literacy skills were effective. Interested in reading literacy experience enhancement, to increase the effect. In the future, the necessary proposals.
Nondegeneracy of positive solutions to nonlinear Hardy–Sobolev equations
Authors: Robert Frédéric
Published: January 2017

In this note, we prove that the kernel of the linearized equation around a positive energy solution in

ℝ
n

${\mathbb{R}^{n}}$

,

n
≥
3

${n\geq 3}$

, to the problem

-

Δ
⁢
W

-

γ
⁢

|
x
|

-
2

⁢
V

=

|
x
|

-
s

⁢

W

2
⋆

⁢

(
s
)

-
1

$-\Delta W-\gamma|x|^{-2}V=|x|^{-s}W^{2^{\star}(s)-1}$

is one-dimensional when

s
+
γ

>
0

$s+\gamma>0$

. Here,

s
∈

[
0
,
2
)

${s\in[0,2)}$

,

0
≤
γ
<

(

n
-
2

)

2

/
4

${0\leq\gamma<(n-2)^{2}/4}$

and

2
⋆

⁢

(
s
)

=

2
⁢

(

n
-
s

)

/

(

n
-
2

)

${2^{\star}(s)=2(n-s)/(n-2)}$

.
Refined Regularity of the Blow-Up Set Linked to Refined Asymptotic Behavior for the Semilinear Heat Equation
Authors: Ghoul Tej-Eddine , Nguyen Van Tien , Zaag Hatem
Published: January 2017

We consider

u
⁢

(
x
,
t
)

${u(x,t)}$

, a solution of

∂
t

⁡
u

=

Δ
⁢
u

+

|
u
|

p
-
1

⁢
u

${\partial_{t}u=\Delta u+|u|^{p-1}u}$

which blows up at some time

T
>
0

${T>0}$

, where

u
:

ℝ
N

×

[
0
,
T
)

→
ℝ

${u:\mathbb{R}^{N}\times[0,T)\to\mathbb{R}}$

,

p
>
1

${p>1}$

and

(

N
-
2

)

⁢
p

<

N
+
2

${(N-2)p<N+2}$

. Define

S
⊂

ℝ
N

${S\subset\mathbb{R}^{N}}$

to be the blow-up set of u, that is, the set of all blow-up points. Under suitable non-degeneracy conditions, we show that if S contains an

(

N
-
ℓ

)

${(N-\ell)}$

-dimensional continuum for some

ℓ
∈

{
1
,
…
,

N
-
1

}

${\ell\in\{1,\dots,N-1\}}$

, then S is in fact a

𝒞
2

${\mathcal{C}^{2}}$

manifold. The crucial step is to make a refined study of the asymptotic behavior of u near blow-up. In order to make such a refined study, we have to abandon the explicit profile function as a first-order approximation and take a non-explicit function as a first-order description of the singular behavior. This way we escape logarithmic scales of the variable

(

T
-
t

)

${(T-t)}$

and reach significant small terms in the polynomial order

(

T
-
t

)

μ

${(T-t)^{\mu}}$

for some

μ
>
0

${\mu>0}$

. Knowing the refined asymptotic behavior yields geometric constraints of the blow-up set, leading to more regularity on S.
Examination of the reliability of an inertial sensor-based gait analysis system
Authors: Orlowski Katja , Eckardt Falko , Herold Fabian , Aye Norman , Edelmann-Nusser Jürgen , Witte Kerstin
Published: January 2017

Gait analysis is an important and useful part of the daily therapeutic routine. InvestiGAIT, an inertial sensor-based system, was developed for using in different research projects with a changing number and position of sensors and because commercial systems do not capture the motion of the upper body. The current study is designed to evaluate the reliability of InvestiGAIT consisting of four off-the-shelf inertial sensors and in-house capturing and analysis software. Besides the determination of standard gait parameters, the motion of the upper body (pelvis and spine) can be investigated. Kinematic data of 25 healthy individuals (age: 25.6±3.3 years) were collected using a test-retest design with 1 week between measurement sessions. We calculated different parameters for absolute [e.g. limits of agreement (LoA)] and relative reliability [intraclass correlation coefficients (ICC)]. Our results show excellent ICC values for most of the gait parameters. Midswing height (MH), height difference (HD) of initial contact (IC) and terminal contact (TC) and stride length (SL) are the gait parameters, which did not exhibit acceptable values representing absolute reliability. Moreover, the parameters derived from the motion of the upper body (pelvis and spine) show excellent ICC values or high correlations. Our results indicate that InvestiGAIT is suitable for reliable measurement of almost all the considered gait parameters.
Early mixed hematopoietic chimerism detection by digital droplet PCR in patients undergoing gender-mismatched hematopoietic stem cell transplantation
Authors: Waterhouse Miguel , Pfeifer Dietmar , Follo Marie , Duyster Justus , Schäfer Henning , Bertz Hartmut , Finke Jürgen
Published: January 2017

Background:

Clinical decision making after allogeneic stem cell transplantation (HSCT) is partially based on hematopoietic chimerism analysis. Polymerase chain reaction amplification of polymorphic short tandem repeats (STR-PCR) is currently considered the gold standard for chimerism surveillance after transplantation. Nevertheless, this method has shown several limitations. Emerging technologies such as digital PCR (dPCR) has been applied to detect hematopoietic chimerism. Despite previous reports, the clinical usefulness of dPCR is unclear because the studies were performed in limited patient populations with short follow-ups.

Methods:

In order to compare hematopoietic chimerism detection time and rate, we analyzed 591 samples from 155 patients undergoing gender-mismatched HSCT using STR-PCR and dPCR. We also established the correlation between both methods in artificial DNA mixtures prepared in known proportions and in clinical samples.

Results:

Depending on the artificial DNA mixture analyzed the correlation coefficient between both methods was 0.9946 and 0.9732. The limit of detection for dPCR was 0.01%. Of 157 samples with donor and recipient DNA, mixed chimerism (MC) was detected solely by dPCR in 66 samples. Within the group of patients relapsing after HSCT (n=32) MC was detected earlier in 15 of these patients with dPCR in comparison with STR-PCR. The mean time from MC detection to relapse was 155 days (range: 13–385 days) and 65 days (range: 0–203 days) for dPCR and STR-PCR, respectively.

Conclusions:

dPCR is a sensitive and accurate method for the quantification of hematopoietic chimerism allowing earlier MC detection compared to STR-PCR.
Which of low-density lipoprotein cholesterol estimates can be used in children with type 1 diabetes?
Authors: Bugajska Jolanta , Berska Joanna , Mamica Katarzyna , Wachacka Karolina , Sztefko Krystyna
Published: January 2017

Background:

One of the strongest risk factors of cardiovascular disease is a high concentration of low-density lipoprotein cholesterol (LDL-C); thus, the accurate measurement of LDL-C concentration in children is important. The aim of this study was to compare the concentration of LDL-C measured by direct method and the LDL-C concentration estimated by different formulas with the modified β-quantification method in children with type 1 diabetes.

Methods:

Thirty-one serum samples received from diabetic children (15/18; M/F) and 26 serum samples taken from nondiabetic children (18/14; M/F) were used in the study. LDL-C concentrations were determined by direct enzymatic method (LDL-CD) and the modified β-quantification method (LDL-CmBQ). The concentration of LDL-C was also calculated by different formulas.

Results:

The results of LDL-CmBQ and LDL-CD correlated. However, the correlation coefficient obtain in the nondiabetic samples was much higher (r=0.927; p<0.001) than the correlation coefficient for LDL-CmBQ and LDL-CD concentration obtained in the diabetic samples (r=0.691; p<0.001). Additionally, the coefficients of correlation between the LDL-CmBQ concentration and the LDL-C concentrations calculated by different formulas were lower in diabetic (range: 0.514–0.693) than in nondiabetic samples (range: 0.834–0.937). Bland-Altman plots showed much higher confidence intervals for 95% limits of agreement for the differences between LDL-CmBQ and LDL-CD as well as for the differences between LDL-CmBQ and LDL-C estimated by different formulas for samples from the diabetic samples compared with nondiabetic samples.

Conclusions:

The limitations of methods measurement and of each of the formulas should be taken into account when a medical decision to lower LDL-C is made in the treatment of diabetic children.
Selective solvent evaporation from binary mixtures of water and tetrahydrofuran using a falling film microreactor
Authors: von Bomhard Sibylle , Schelhaas Karl-Peter , Alebrand Sabine , Musyanovych Anna , Maskos Michael , Drese Klaus S.
Published: January 2017

In this work, a falling film micro reactor was investigated regarding its ability to continuously eliminate tetrahydrofuran (THF) out of a THF-water mixture via nitrogen stripping. Mass transfer measurements were performed at different temperatures and flow rates. The residual content of THF in the eluate was quantified with high precision (<0.1%) via density measurements. Remarkably, complete elimination of THF could be achieved for liquid volume flow rates smaller than 2 ml/min and nitrogen volume flow rates larger than 400 ml/min at all three investigated temperatures (55°C, 60°C, and 65°C). In order to assist future design processes of such binary microstripping systems, we further developed a mass transfer model for this separation process extending an existing model for evaporation of a pure liquid. The good agreement of experimental data and calculations in the overall investigated parameter range (≤20%, for gas flow rates below 500 ml/min ≤11%) shows the potential of the model for the prediction of alternative operational parameter settings, e.g. at different THF entrance concentrations.
Travelling Ideologies: A Story of Whiteness
Authors: Cogeanu Oana
Published: January 2017

Prompted by the observations of a European scholar in African-American studies living in South-East Asia, this article addresses the ideological value of whiteness with a view to understanding its apparently global aesthetic fascination and societal power. To this purpose, the article traces the European, American and Asian conceptualization and employment of the signs of whiteness. The first section investigates the correlated philosophical and scientific construction of whiteness as a racial signifier in Europe. The second section focuses on social and cultural practices of white vs. black identification and the critique thereof in the United States. The third section highlights the appeal of whiteness as a status signifier in Asia. Whiteness is commonly employed as a sign of superiority, assumed by the self or assigned to the other (within): the article suggests that such power derives from a common mystical symbolism, upheld by philosophy, sanctioned by science, implemented by social policy and marketed by corporations.
Representations of Central and Eastern Europe in Travelogues of Romanian and Polish Public Figures
Authors: Goleşteanu Raluca
Published: January 2017

This article proposes a reading of Milica Bakić-Hayden’s concept of “nesting orientalisms” in a wider regional context, by showing some of its first manifestations, as employed one hundred years or so ago. The debut of this phenomenon is part of the nineteenth century trend of traveling to “Eastern Europe,” and of appropriating it as such, in the desire to compete with the previous century, especially with the latter’s attempt of designing the map according to the dichotomy: “enlightened-ignorant peoples.”

Consequently, the adoption of the concept of “Eastern Europe” by western public opinion triggered reactions from the part of the local élites expressed in the establishment of a corpus of texts, which reflect on the nearby geographical area. This effort represented in fact the third stage of the west-east dynamics that accompanied modernization in the region. The texts to be discussed in this article, apart from the century’s blind faith in progress, display the obsession of being “in between,” raising it to a sine qua non condition of the region; their authors often found themselves in difficulties in relation to dilemmas like professional/national identities, local/central loyalties, religious/secular views.
From Woods and Water to the Gran Bazaar: Images of Romania in English Travelogues after WWI
Authors: Sâsâiac Andi
Published: January 2017

Although globalization brings different countries and cultures in closer and closer contact, people are still sensitive when it comes to aspects such as cultural specificity or ethnicity. The collapse of communism and the extension of the European Union have determined an increase of interest in Romania’s image, both on the part of foreigners and of Romanians themselves. The purpose of this paper is to follow the development of Romania’s image in English travelogues in the last hundred years, its evolution from a land of “woods and water” in the pre-communist era to a “grand bazaar” in the post-communist one, with clear attempts, in recent years, to re-discover a more idyllic picture of the country, one that should encourage ecological tourism. The article is also intended to illustrate the extra-textual (historical, economic, cultural) factors that have impacted, in different ways, on this image evolution.
Exploring discourse practices in American wedding invitations
Authors: Eslami Zohreh R. , Ribeiro Angelica , Snow Marianne , Wharton Anna
Published: January 2017

The paper looks into discourse practices in American wedding invitations, identifying possible trends and patterns. Using predominantly genre analysis (
New records of bats from southern Morocco (Atlantic Sahara) and notes on echolocation
Authors: Moores Richard , Brown Dan
Published: January 2017

In this short note, we report the first records for two bat species: the Egyptian free-tailed bat
Crystal structure of (Z)-3-hydroxy-3-(4-methoxyphenyl)-1-(pyridin-2-yl)prop-2-en-1-one, C15H13NO3
Authors: Radi Smaail , Tighadouini Said , Eddike Driss , Mabkhot Yahia N. , Tillard Monique
Published: January 2017

C15H13NO3, monoclinic, Cc (No. 9), a = 3.9230(3) Å, b = 26.578(2) Å, c = 11.7147(12) Å, β = 94.028(8)°, V = 1218.4(2) Å3, Z = 4, R
gt(F) = 0.0387, wR
ref(F
2) = 0.0877, T = 173 K.
Textural and morphology changes of mesoporous SBA-15 silica due to introduction of guest phase
Authors: Bulánek Roman , Čičmanec Pavel
Published: January 2017

The research focuses on study of guest phase effect on the surface area and pore volume of SBA-15 with the emphasis on elucidation of reasons for these changes. The changes of surface area and pore volume are evident from evaluated N2 adsorption isotherms of VOx-SBA-15 even for samples with relative low content of supported guest phase, which is “atomically” spread on the surface in the form of anchored monomeric vanadyl species. These species cannot block the pore with diameter of 10 nm, nevertheless the presence of such phase causes decrease in adsorbed nitrogen during physisorption. Comparison of guest phase amount with differences in adsorbed amount of nitrogen led to conclusion that each vanadyl complex prevents adsorption of about one or two N2 molecules in the layer and influences two adsorption layers. Significant pore blocking occurs in the VOx-SBA-15 materials only in the case of presence bulk oxide-like nanospecies. Re-structuralization of silica mimicking phase separation phenomena relying on spinodal decomposition of a system was observed by SEM/TEM analysis and adsorption isotherms inspection for materials with high vanadium content.
Bi-layered electrospun nanofibrous polyurethane-gelatin scaffold with targeted heparin release profiles for tissue engineering applications
Authors: Safikhani Mohammad Mahdi , Zamanian Ali , Ghorbani Farnaz , Asefnejad Azadeh , Shahrezaee Mostafa
Published: January 2017

Tissue engineering is a biotechnology that is used to develop biological substitutes to restore, maintain, or improve functions. Thus, the porous scaffolds are used to accommodate cells in tissue engineering. In this research, three dimensional (3D) bi-layered polyurethane (PU)-gelatin nanofibrous scaffolds were prepared by the electrospinning method, after which the capability of the released heparin as an anti-coagulation factor was evaluated. Electrospinning has been extensively investigated for the preparation of fibers that exhibit a high surface area to volume ratio. Results showed that scanning electron microscopy (SEM) micrographs exhibited a smooth surface as well as a highly porous and bead-free structure, in which fibers were distributed in the range of 100–600 nm. The modulus and ultimate tensile strength (UTS) decreased and increased, respectively, after crosslinking the reaction of polymers. This process also reduced swelling ratio, the hydrolytic biodegradation rate, and the release rate as a function of time. Moreover, an in vitro assay demonstrated that 3D nanofibrous scaffolds supported L929 fibroblast cell viability and that cells adhered and spread on the fibers. Based on the obtained results, the heparin-loaded electrospinning nanofibrous scaffolds have initial physicochemical and mechanical properties to protect neo-tissue formation.
Multiscale Model for the Dielectric Permittivity
Authors: Pérez-Madrid Agustín , Lapas Luciano C. , Rubí J. Miguel
Published: January 2017

We present a generalisation of the Debye relaxation model for the dielectric permittivity in the case in which the global relaxation process is the result of many elementary excitations. The relaxation dynamics is in this case non-Markovian. In the case of many events, for which the central limit theorem holds and Gaussianity as well as the assumption of independency are both plausible, the global relaxation time is given by a log-normal function. The hierarchy of relaxation times leads to a generalised expression of the dielectric permittivity.
Human motifs at Neolithic Tepe Baluch, north-east Iran
Authors: Sabori Hadi , Khorasani Mina Norouzi , Bolandi Reza
Published: January 2017

The start of sedentary farming and herding in the Middle East transformed social and economic organisation and reshaped ideological structures and artistic representations. Tepe Baluch is a Neolithic settlement on the Neyshabur Plain in north-east Iran. Amongst the ceramic material excavated at the site, one particular sherd is of great interest. It is decorated with two (possibly three) motifs in the form of human figures. For this date and region, such Neolithic iconography is rare, and this short article develops a comparative analysis to explore its significance.
The Application of Callista Roy Adaptation Model in the Care of Patients with Multiple Sclerosis – Case Report
Authors: Rosińczuk Joanna , Kołtuniuk Aleksandra , Górska Magdalena , Uchmanowicz Izabella
Published: January 2017

Introduction. Multiple sclerosis (Sclerosis Multiplex — MS) is a chronic disease of the central nervous system characterized by inflammation and the loss of myelin sheath surrounding the axon. A result of disseminated demyelination process in patients suffering from MS, is a wide variety of symptoms that lead to changes in terms of functioning both in biological and psychosocial aspects. The skilful preparation of a patient to find the optimal way of dealing with the disease, as well as maintaining independence and joy of life is an essential part of the therapeutic process in patients with MS.Aim. The aim of this study was to use the Callista Roy adaptation model in the care of a patient suffering from multiple sclerosis, namely:— demonstrate the usefulness of the holistic Callista Roy adaptation model in the care of chronically ill patients,— prepare a patient to cope with the problems induced by the disease, based on the nursing process developed in line ith the guidlines of C. Roy model.Case Report. A case study of a 69 year old patient with multiple sclerosis (SM) was prepared on the basis of medical documentation (personal information forms from hospitals), an interview with the patient and direct observations.Discussion. The nursing care model based on the theory by Callista Roy proved to be very useful in the process of taking care of a patient chronically ill with SM, as it guaranteed satisfying the needs of a patient in terms of bio-psychosocial aspect, but it also gave the opportunity to acquire skills to cope with problems resulting from the disease.Conclusions. The nursing process based on the theory by Callista Roy requires from a nurse an individual and holistic approach to a patient and patient’s problems. The model structure provides a comprehensive delivery of nursing care and ensures continuous contact with a patient. This is particularly important in the era of technology development in modern medicine.(JNNN 2015;4(3):121–129)
Physical Functioning of Epileptic Children
Authors: Bryś Anna , Barczykowska Ewa , Małecka Bogumiła , Kurylak Andrzej
Published: January 2017

Introduction. Epilepsy belongs to the most frequently occurring nervous conditions. Depending on the course ofthe disease and on the support provided to the child from his/her closest family, the child’s physical, mental and social functioning differs.Aim. The aim of this paper is the physical functioning of epileptic children in the opinion of their parents.Material and Methods. The study was performed on 94 children with diagnosed epilepsy, treated in the Departmentof Infectious Diseases and Child Neurology, Poznan University of Medical Sciences. A proprietary polling questionnaire as well as a parent-targeted QOLCE (Quality of Life in Childhood Epilepsy Questionnaire) served as the measure; consequently, parents or carers to the children within the study were also included as participants.Results. The studied children were rarely left unmanned during play, and they never spent a night out. In the assessment of the physical functioning performed by fathers and mothers, a statistically significant difference (p≤0.05)was observed; children function better in this section according to mothers. The parents’/carers’ education as well asthe child’s educational facility is a statistically significant (p≤0.05) factor influencing physical functioning of a child.No significant difference was noted between the child’s area of residence (p≥0.05) and age (p≥0.05) and his/herphysical functioning.Conclusions. The majority of the studied children attended a school or a kindergarten. Epilepsy significantly limitschildren when it comes to their physical functioning. Among factors influencing the level of a child’s physical functioning, parents’ education and child’s educational facility present themselves as the most relevant. (JNNN 2015;4(4):146–151)