bluuebunny/crossref_metadata_2025 huggingface dataset:
Manajemen Komunikasi dalam Perwujudan Tanggung Jawab Sosial Perusahaan PT Jasa Marga (Persero) Tbk Melalui Program Binaan Banksasuci
Authors: Kartikawati Dwi , Puspitasari Rahmawati
Published: December 2020

Fokus riset ini adalah untuk mengetahui implementasi manajemen Tanggung Jawab Sosial Perusahaan (TJPS) PT Jasa Marga (Persero) Tbk dalam penyaluran bantuan pada Program Binaan Banksasuci. Program Banksasuci merupakan program bina lingkungan sebagai upaya TJSP  PT Jasa Marga (Persero) Tbk yang bertujuan untuk mengelola sungai secara terintegrasi, yaitu dengan memelopori penanaman pohon untuk mengurangi polusi, mengelola keberagaman hayati yang berada di bantaran sungai, dan mengelola sampah yang didapat dari sungai Cisadane. Program ini memerlukan manajemen komunikasi yang baik dalam mengoptimalkan sumbedaya komunikasi yang ada untuk mencapai keefektifan program. PT Jasa Marga (Persero) Tbk selalu berkomitmen untuk menjaga lingkungan dengan mengedepankan regulasi yang berlaku terhadap undang-undang CSR. Dengan menggunakan penelitian kualitatif analitik dan teknik pengumpulan data dengan wawancara mendalam, studi observasi dan studi dokumen. Maka hasil penelitian menunjukkan bahwa manajemen komunikasi dilakukan mulai dari tahapan perencanaan komunikasi pada program Banksasuci, tahap persiapan, tahap pelaksanaan komunikasi penandatanganan perjanjian kerjasama dan penyerahan bantuan dan tahap monitoring melalui reminding call dan whatshapp grup dan evaluasi. Keseluruhan kegiatan CSR yang dilkukan mengedepankan 3 (tiga) prinsip CSR yaitu Triple Bottom Line. Kata kunci: Manajemen Komunikasi, Tangung Jawab Sosial Perusahaan
Pola Komunikasi Insan Berkemampuan Khusus: Studi Etnografi Komunikasi pada Interaksi Sosial Insan Berkemampuan Khusus di Rumah Autis Cabang Depok
Authors: Ayuningtyas Fitria , Venus Anter , Suryana Asep , Yustikasari Yustikasari
Published: December 2020

Komunikasi merupakan sesuatu hal yang fundamental dalam kehidupan sehari-hari. Peran dasar komunikasi adalah jembatan untuk membangun interaksi sosial. Komunikasi digunakan setiap manusia sebagai sarana dalam berinteraksi sosial, namun beberapa orang terkadang mengalami gangguan dalam berkomunikasi dengan faktor gangguan yang tentunya berbeda-beda. Salah satu orang yang mengalami gangguan komunikasi dalam berinteraksi yaitu anak berkemampuan khusus. Insan Berkemampuan Khusus (atau biasa dikenal oleh masyarakat umum sebagai manusia berkebutuhan khusus) telah resmi dicanangkan pada tanggal 3 Desember 2019, momentum hari Disabilitas Internasional yang jatuh setiap tanggal 3 Desember juga oleh Rumah Autis dianggap tepat untuk dijadikan hari Insan Berkemampuan Khusus atau IBK’s day. Pendekatan yang digunakan dalam penelitian ini adalah pendekatan penelitian kualitatif. Metode penelitian yang digunakan dalam penelitian ini adalah metode penelitian etnografi komunikasi.Hasil pengamatan dan wawancara yang didapat kemudian dianalisis menggunakan elemen yang terdapat pada etnografi komunikasi yang lebih dikenal dengan kata SPEAKING yang terdiri dari setting/scene, participants, ends, act sequence, keys, instrumentalities, norms of interaction, genre. Berdasarkan hasil penelitian ini, ditemukan bahwa masalah utama dari insan berkemampuan khusus terutama anak autis adalah masalah komunikasi, interaksi sosial dan perilaku. Komunikasi yang digunakan oleh anak autis sangat unik dan menarik serta karakteristik dari autisme ini sangatlah beragam.
Psychometric Properties of the Resilience Scale for Adolescents (READ) and Measurement Invariance Across Two Different German-Speaking Samples
Authors: Janousch Clarissa , Anyan Frederick , Hjemdal Odin , Hirt Carmen Nadja
Published: December 2020

The Resilience Scale for Adolescents (READ) is a highly rated scale for measuring protective factors of resilience. Even though the READ has been validated in several different cultural samples, no studies have validated the READ across samples in German from Switzerland and Germany. The purpose of this study was to explore the construct validity of the German READ version in two samples from two different countries and to test the measurement invariance between those two samples. A German sample (n = 321, M = 12.74, SD = 0.77) and a German-speaking Swiss sample (n = 349, M = 12.67, SD = 0.69) of seventh graders completed the READ, Hopkins Symptom Checklist (HSCL-25), Rosenberg Self-Esteem Scale (RSE), General Self-Efficacy Scale, and Satisfaction with Life Scale (SWL). The expected negative correlations between READ and HSCL-25 and the positive correlations between RSE, self-efficacy, and SWL were supported. Furthermore, the results of the measurement invariance demonstrated that the originally proposed five-dimensional structure is equal in the German and Swiss samples, and it can be assumed that the same construct was assessed by excluding one item. The five-factor, 27-item solution is a valid and reliable self-report measure of protective factors between two German-speaking samples.
Perpetual American Cancellable Standard Options in Models with Last Passage Times
Authors: Gapeev Pavel V. , Li Libo , Wu Zhuoshu
Published: December 2020

We derive explicit solutions to the perpetual American cancellable standard put and call options in an extension of the Black–Merton–Scholes model. It is assumed that the contracts are cancelled at the last hitting times for the underlying asset price process of some constant upper or lower levels which are not stopping times with respect to the observable filtration. We show that the optimal exercise times are the first times at which the asset price reaches some lower or upper constant levels. The proof is based on the reduction of the original optimal stopping problems to the associated free-boundary problems and the solution of the latter problems by means of the smooth-fit conditions.
Selectivity of Pre and Postemergence Herbicides in Single or Combined Applications in Castor Crop
Authors: Costa Augusto G. F. , Sofiatti Valdinei , Maciel Cleber D. G. , Freitas Jalmi G. , Cardoso Gleibson D. , Wirgues Larissa M.
Published: December 2020

One of the main challenges in castor crop (Ricinus communis L.) production is efficient weed management mainly due to limited options of selective herbicides. This study evaluated the selectivity of herbicides applied alone or in combination in pre- and postemergence applications in castor crop. Two field experiments were carried out under irrigation conditions in a semi-arid region of Northeast Brazil. It was found that the visual symptoms of phytointoxication of the herbicides used on castor were mild in both experiments. Consequently, there were no significant interferences on plant height, number of racemes, and grain (seed) yield. Pre-emergence applications (g ha−1) of trifluralin (1800), pendimethalin (1500), clomazone (750), clomazone + trifluralin (750 + 1800), and clomazone + pendimethalin (750 + 1500) followed by chlorimuron-ethyl in postemergence (15 g ha−1) are selective to castor. The application (g ha−1) of pendimethalin + clomazone (1000 + 500) in pre-emergence, associated with chlorimuron-ethyl (10 and 15), metamitron (2800 and 4200), ethoxysulfuron (60 and 80), or halosulfuron-methyl (75 and 112.5) in one or two applications in postemergence, as single or split applications, in an interval of 14 days, are selective to castor crop.
Agronomic Approaches for the Remediation of Contaminated Soils
Authors: Fagnano Massimo , Fiorentino Nunzio
Published: December 2020

Contaminated soils can only be efficiently managed if proper procedures are adopted for evaluating the risks due to contamination as well as the actual volume of contaminated soil [...]
Selenomethionine (Se-Met) Induces the Cystine/Glutamate Exchanger SLC7A11 in Cultured Human Retinal Pigment Epithelial (RPE) Cells: Implications for Antioxidant Therapy in Aging Retina
Authors: Ananth Sudha , Miyauchi Seiji , Thangaraju Muthusamy , Jadeja Ravirajsinh N. , Bartoli Manuela , Ganapathy Vadivel , Martin Pamela M.
Published: December 2020

Oxidative damage has been identified as a major causative factor in degenerative diseases of the retina; retinal pigment epithelial (RPE) cells are at high risk. Hence, identifying novel strategies for increasing the antioxidant capacity of RPE cells, the purpose of this study, is important. Specifically, we evaluated the influence of selenium in the form of selenomethionine (Se-Met) in cultured RPE cells on system xc- expression and functional activity and on cellular levels of glutathione, a major cellular antioxidant. ARPE-19 and mouse RPE cells were cultured with and without selenomethionine (Se-Met), the principal form of selenium in the diet. Promoter activity assay, uptake assay, RT-PCR, northern and western blots, and immunofluorescence were used to analyze the expression of xc-, Nrf2, and its target genes. Se-Met activated Nrf2 and induced the expression and function of xc- in RPE. Other target genes of Nrf2 were also induced. System xc- consists of two subunits, and Se-Met induced the subunit responsible for transport activity (SLC7A11). Selenocysteine also induced xc- but with less potency. The effect of Se-met on xc- was associated with an increase in maximal velocity and an increase in substrate affinity. Se-Met increased the cellular levels of glutathione in the control, an oxidatively stressed RPE. The Se-Met effect was selective; under identical conditions, taurine transport was not affected and Na+-coupled glutamate transport was inhibited. This study demonstrates that Se-Met enhances the antioxidant capacity of RPE by inducing the transporter xc- with a consequent increase in glutathione.
Paraoxonase Role in Human Neurodegenerative Diseases
Authors: Reichert Cadiele Oliana , Levy Debora , Bydlowski Sergio P.
Published: December 2020

The human body has biological redox systems capable of preventing or mitigating the damage caused by increased oxidative stress throughout life. One of them are the paraoxonase (PON) enzymes. The PONs genetic cluster is made up of three members (PON1, PON2, PON3) that share a structural homology, located adjacent to chromosome seven. The most studied enzyme is PON1, which is associated with high density lipoprotein (HDL), having paraoxonase, arylesterase and lactonase activities. Due to these characteristics, the enzyme PON1 has been associated with the development of neurodegenerative diseases. Here we update the knowledge about the association of PON enzymes and their polymorphisms and the development of multiple sclerosis (MS), amyotrophic lateral sclerosis (ALS), Alzheimer’s disease (AD) and Parkinson’s disease (PD).
Systematic Review of Exoskeletons towards a General Categorization Model Proposal
Authors: de la Tejera Javier A. , Bustamante-Bello Rogelio , Ramirez-Mendoza Ricardo A. , Izquierdo-Reyes Javier
Published: December 2020

Exoskeletons are an essential part of humankind’s future. The first records regarding the subject were published several decades ago, and the field has been expanding ever since. Their developments will be imperative for humans in the coming decades due to our constant pursuit of physical enhancement, and the physical constraints the human body has. The principal purpose of this article is to formalize research in the field of exoskeletons and introduce the field to more researchers in hopes of expanding research in the area. Exoskeletons can assist and/or aid in the rehabilitation of a person. Recovery exoskeletons are mostly used in medical and research areas; performance exoskeletons can be used in any area. This systematic review explains the precedents of the exoskeletons and gives a general perspective on their general present-day use, and provides a general categorization model with a brief description of each category. Finally, this paper provides a discussion of the state-of-the-art, and the current control techniques used in exoskeletons.
Analysis of EEG, Cardiac Activity Status, and Thermal Comfort According to the Type of Cooling Seat during Rest in Indoor Temperature
Authors: Shin Yunchan , Lee Minjung , Cho Honghyun
Published: December 2020

In this study, electroencephalogram (EEG) and cardiac activity status of the human body while using various types of seats during rest were analyzed in indoor summer conditions. Thermal comfort was also evaluated through a subjective survey. The EEG, cardiac activity status, and subjective survey during rest indicated that the use of ventilation and cold water-cooling seats was effective. This effectiveness was because of the θ-wave and α-wave activation, sensorimotor rhythm, β-wave reduction, and left hemisphere activation, demonstrating that the conditions applied were suitable for rest. According to the analysis of the subjective questionnaire survey, the use of ventilation and cold water-cooling seats provided a more pleasant state than the basic seat, improving the subject’s warmth and comfort, and also the concentration. In addition, the use of a cold water-cooling seat provided the highest satisfaction level, being the most favorable condition for rest.
Enhancement of a New Methodology Based on the Impulse Excitation Technique for the Nondestructive Determination of Local Material Properties in Composite Laminates
Authors: Boursier Niutta Carlo
Published: December 2020

A new approach for the nondestructive determination of the elastic properties of composite laminates is presented. The approach represents an improvement of a recently published experimental methodology based on the Impulse Excitation Technique, which allows nondestructively assessing local elastic properties of composite laminates by isolating a region of interest through a proper clamping system. Different measures of the first resonant frequency are obtained by rotating the clamping system with respect to the material orientation. Here, in order to increase the robustness of the inverse problem, which determines the elastic properties from the measured resonant frequencies, information related to the modal shape is retained by considering the effect of an additional concentrated mass on the first resonant frequency. According to the modal shape and the position of the mass, different values of the first resonant frequency are obtained. Here, two positions of the additional mass, i.e., two values of the resonant frequency in addition to the unloaded frequency value, are considered for each material orientation. A Rayleigh–Ritz formulation based on higher order theory is adopted to compute the first resonant frequency of the clamped plate with concentrated mass. The elastic properties are finally determined through an optimization problem that minimizes the discrepancy on the frequency reference values. The proposed approach is validated on several materials taken from the literature. Finally, advantages and possible limitations are discussed.
Ternary Mixes of Self-Compacting Concrete with Fly Ash and Municipal Solid Waste Incinerator Bottom Ash
Authors: Simões B. , da Silva P. R. , Silva R. V. , Avila Y. , Forero J. A.
Published: December 2020

This study aims to evaluate the potential of incorporating fly ash (FA) and municipal solid waste incinerator bottom ash (MIBA) as a partial substitute of cement in the production of self-compacting concrete mixes through an experimental campaign in which four replacement levels (i.e., 10% FA + 20% MIBA, 20% FA + 10% MIBA, 20% FA + 40% MIBA and 40% FA + 20% MIBA, apart from the reference concrete) were considered. Compressive and tensile strengths, Young’s modulus, ultra-sonic pulse velocity, shrinkage, water absorption by immersion, chloride diffusion coefficient and electrical resistivity were evaluated for all concrete mixes. The results showed a considerable decline in both mechanical and durability-related performances of self-compacting concrete with 60% of substitution by MIBA mainly due to the aluminium corrosion chemical reaction. However, workability properties were not significantly affected, exhibiting values similar to those of the control mix.
Microgravity Induces Transient EMT in Human Keratinocytes by Early Down-Regulation of E-Cadherin and Cell-Adhesion Remodeling
Authors: Ricci Giulia , Cucina Alessandra , Proietti Sara , Dinicola Simona , Ferranti Francesca , Cammarota Marcella , Filippini Antonio , Bizzarri Mariano , Catizone Angela
Published: December 2020

Changes in cell–matrix and cell-to-cell adhesion patterns are dramatically fostered by the microgravity exposure of living cells. The modification of adhesion properties could promote the emergence of a migrating and invasive phenotype. We previously demonstrated that short exposure to the simulated microgravity of human keratinocytes (HaCaT) promotes an early epithelial–mesenchymal transition (EMT). Herein, we developed this investigation to verify if the cells maintain the acquired invasive phenotype after an extended period of weightlessness exposure. We also evaluated cells’ capability in recovering epithelial characteristics when seeded again into a normal gravitational field after short microgravity exposure. We evaluated the ultra-structural junctional features of HaCaT cells by Transmission Electron Microscopy and the distribution pattern of vinculin and E-cadherin by confocal microscopy, observing a rearrangement in cell–cell and cell–matrix interactions. These results are mirrored by data provided by migration and invasion biological assay. Overall, our studies demonstrate that after extended periods of microgravity, HaCaT cells recover an epithelial phenotype by re-establishing E-cadherin-based junctions and cytoskeleton remodeling, both being instrumental in promoting a mesenchymal–epithelial transition (MET). Those findings suggest that cytoskeletal changes noticed during the first weightlessness period have a transitory character, given that they are later reversed and followed by adaptive modifications through which cells miss the acquired mesenchymal phenotype.
Multigap Resistive Plate Chambers for Time of Flight Applications
Authors: Wang Yi , Yu Yancheng
Published: December 2020

With the advantages of high-performance, easy to build and relatively low cost, the multigap resistive plate chamber has been arousing broad interests over the last few decades. It has become a new standard technology for the time of flight system in high energy physics experiments. In this article, we will give a description of the structure and the operating principles of the MRPC detector and focus on reviewing the applications on the time of flight system in several famous experiments. The performances, including time resolution and particle identification, are discussed in detail. Some recent advances and points of view for the future development of the next generation MRPC are also outlined.
Novel Resistive Sensor Design Utilizing the Geometric Freedom of Additive Manufacturing
Authors: Watschke Hagen , Goutier Marijn , Heubach Julius , Vietor Thomas , Leichsenring Kay , Böl Markus
Published: December 2020

Direct additive manufacturing (AM) of sensors has in recent years become possible, but still remains a largely unexplored area. This work proposes a novel resistive sensor design that utilizes the geometric freedom offered by AM, especially by material extrusion, to enable a customizable and amplified response to force and deformation. This is achieved by using a multi-material design made of an elastomer and an electrically conductive polymer that enables a physical shortening of the conductive path under compressive load through a specific definition of shape. A number of different variants of this novel sensor design are tested, measuring their mechanical and electrical behavior under compression. The results of these tests confirm a strong resistive response to mechanical loading. Furthermore, the results provide insight into the influencing factors of the design, i.e., the gap size between the conductive pathing and the stiffness of the sense element support structure are found to be primary influencing factors governing sensor behavior.
Improved Hargreaves Model Based on Multiple Intelligent Optimization Algorithms to Estimate Reference Crop Evapotranspiration in Humid Areas of Southwest China
Authors: Wu Zongjun , Cui Ningbo , Zhu Bin , Zhao Long , Wang Xiukang , Hu Xiaotao , Wang Yaosheng , Zhu Shidan
Published: December 2020

Reference crop evapotranspiration (ET0) is an important indicator for precise regulation of crop water content, irrigation forecast formulation, and regional water resources management. The Hargreaves model (HG) is currently recognized as the simplest and most effective ET0 estimation model. To further improve the prediction accuracy of the HG model, this study is based on the data of 98 meteorological stations in southwest China (1961–2019), using artificial bee colony (ABC), differential evolution (DE) and particle swarm optimization (PSO) algorithms to calibrate the HG model globally. The standard ET0 value was calculated by FAO-56 Penman–Monteith (PM) model. We compare the calculation accuracy of 3 calibrated HG models and 4 empirical models commonly used (Hargreaves, Priestley–Taylor, Imark–Allen and Jensen–Hais). The main outcomes demonstrated that on a daily scale, the calibrated HG models (R2 range 0.74–0.98) are more accurate than 4 empirical models (R2 range 0.55–0.84), and ET0-PSO-HG has the best accuracy, followed by ET0-ABC-HG and ET0-DE-HG, with average R2 of 0.83, 0.82 and 0.80, average RRMSE of 0.23 mm/d, 0.25 mm/d and 0.26 mm/d, average MAE of 0.52 mm/d, 0.53 mm/d and 0.57 mm/d, and average GPI of 0.17, 0.05, and 0.04, respectively; on a monthly scale, ET0-PSO-HG also has the highest accuracy, followed by ET0-ABC-HG and ET0-DE-HG, with median R2 of 0.96, 0.95 and 0.94, median RRMSE of 0.16 mm/d, 0.17 mm/d and 0.18 mm/d respectively, median MAE of 0.46 mm/d, 0.50 mm/d, and 0.55 mm/d, median GPI of 1.12, 0.44 and 0.34, respectively. The calibrated HG models (relative error of less than 10.31%) are also better than the four empirical models (relative error greater than 16.60%). Overall, the PSO-HG model has the most accurate ET0 estimation on daily and monthly scales, and it can be suggested as the preferred model to predict ET0 in humid regions in southwest China regions.
Structural Characterisation of Dimeric Esters in α-Pinene Secondary Organic Aerosol Using N2 and CO2 Ion Mobility Mass Spectrometry
Authors: Iinuma Yoshiteru , Ramasamy Sathiyamurthi , Sato Kei , Kołodziejczyk Agata , Szmigielski Rafal
Published: December 2020

The atmospheric oxidation of monoterpenes leads to the formation of secondary organic aerosol (SOA). While numerous works have been carried out in the past to characterise SOA at a molecular level, the structural elucidation of SOA compounds remains challenging owing to the lack of authentic standard compounds. In this work, the structures of α-pinene originating dimeric esters in SOA with m/z 357 (C17H25O8-) and m/z 367 (C19H27O7-) were characterised using UPLC/ESI(-)IMS-TOFMS2 (ultra-performance liquid chromatography coupled to ion mobility spectrometry tandem time-of-flight mass spectrometry). The measured collision cross-section (ΩN2) values were compared to theoretically calculated ΩN2 values. Selected product ions of dimeric compounds and the authentic standard compounds of product ions were subjected to CO2-IMS-TOFMS for more detailed structural characterisation. Our results were consistent with previously reported subunits of the m/z 357 (terpenylic acid and cis-pinic acid), and the m/z 367 (10-hydroxy-cis-pinonic acid and cis-pinic acid) ions. The measured and calculated ΩN2 values of m/z 367 ions further support the conclusion of earlier structural characterisation; however, the structure of the m/z 357 ion remains vague and requires further characterisation studies with a synthesised reference compound.
A Review on the Factors Affecting the Use of Offsite Construction in Multifamily Housing in the United States
Authors: Gusmao Brissi Sara , Debs Luciana , Elwakil Emad
Published: December 2020

The increasing demand for multifamily housing in the United States requires alternatives for building more affordable and sustainable housing to improve the quality of life for millions of families. Offsite construction (OSC) strategies may be a viable alternative for tackling this problem. Although the use of OSC is significant in the multifamily housing market in the world and it is also very promising in the US, a scarce amount of literature has focused on this topic. The purpose of this study is to identify specific factors that affect decisions on the use of OSC in multifamily housing in the US. Focusing on the sustainability dimensions of construction—social, environmental, and economic—the authors reviewed literature that was published between 2000 and 2019 and identified factors that are related to OSC adoption in general construction, in housing construction, and, more specifically, in multifamily housing construction in the US. Subsequently, a discussion on some important factors affecting decisions on the use of OSC in the American multifamily market is provided. The discussion focused on factors that, although important, have been under explored in the literature that addresses the use of OSC in multifamily projects, especially in the US, which are: customer’s attitude, building performance, and building comfort and indoor environmental quality (IEQ). In addition, a brief discussion regarding the importance of design to the uptake of OSC in multifamily projects is provided. This is one of the first studies dedicated to exploring the social, environmental, and economic factors that affect the use of OSC in multifamily housing in the US. The study also identifies research gaps, which serve as a roadmap for future research.
Numerical Simulation and Parametric Analysis of Precast Concrete Beam-Slab Assembly Based on Layered Shell Elements
Authors: Feng De-Cheng , Xiong Cheng-Zhuo , Brunesi Emanuele , Parisi Fulvio , Wu Gang
Published: December 2020

Precast concrete (PC) plays an important role in the industrialization processes of buildings, so it is critical to study the seismic performance of such structures. Several experimental and numerical studies have been conducted to investigate the behavior of PC beam-to-column connections. However, most of the previous studies neglect the contribution of slabs. In light of this, this paper presents a numerical simulation method for dry connected beam-slab assemblies based on the layered shell element available in OpenSees. The beams were modeled with fiber elements, while the slabs were modeled with layered shell elements. The developed model was validated by simulating a typical beam-slab assembly test, with the characteristics of hysteretic performance found to be well reflected by the model. Moreover, a parametric study was performed to quantify the influence of slab parameters. The results showed that the thickness of the slab had a significant effect on the hysteretic performance of the specimen and that the influence of the slab width was obviously reduced after it exceeded a certain limit. Besides, the effect of the reinforcement ratio on stiffness and loadbearing capacity was not obvious and was accompanied by a slight positive correlation with the energy dissipation capacity.
Fludarabine, High-Dose Cytarabine and Idarubicin-Based Induction May Overcome the Negative Prognostic Impact of FLT3-ITD in NPM1 Mutated AML, Irrespectively of FLT3-ITD Allelic Burden
Authors: Minetto Paola , Candoni Anna , Guolo Fabio , Clavio Marino , Zannier Maria Elena , Miglino Maurizio , Dubbini Maria Vittoria , Carminati Enrico , Sicuranza Anna , Ciofini Sara , Colombo Nicoletta , Pugliese Girolamo , Marcolin Riccardo , Santoni Adele , Ballerini Filippo , Lanino Luca , Cea Michele , Gobbi Marco , Bocchia Monica , Fanin Renato , Lemoli Roberto Massimo
Published: December 2020

The mutations of NPM1 and FLT3-ITD represent the most frequent genetic aberration in acute myeloid leukemia. Indeed, the presence of an NPM1 mutation reduces the negative prognostic impact of FLT3-ITD in patients treated with conventional “3+7” induction. However, little information is available on their prognostic role with intensified regimens. Here, we investigated the efficacy of a fludarabine, high-dose cytarabine and idarubicin induction (FLAI) in 149 consecutive fit AML patients (median age 52) carrying the NPM1 and/or FLT3-ITD mutation, treated from 2008 to 2018. One-hundred-and-twenty-nine patients achieved CR (86.6%). After a median follow up of 68 months, 3-year overall survival was 58.6%. Multivariate analysis disclosed that both NPM1mut (p < 0.05) and ELN 2017 risk score (p < 0.05) were significant predictors of survival. NPM1-mutated patients had a favorable outcome, with no significant differences between patients with or without concomitant FLT3-ITD (p = 0.372), irrespective of FLT3-ITD allelic burden. Moreover, in landmark analysis, performing allogeneic transplantation (HSCT) in first CR proved to be beneficial only in ELN 2017 high-risk patients. Our data indicate that FLAI exerts a strong anti-leukemic effect in younger AML patients with NPM1mut and question the role of HSCT in 1st CR in NPM1mut patients with concomitant FLT3-ITD.
Nano-PAA-CuCl2 Composite as Fenton-Like Reusable Catalyst to Enhanced Degrade Organic Pollutant MB/MO
Authors: Dang Yang , Cheng Yu , Zhou Yukun , Huang Yifei , Wang Kaige
Published: December 2020

The treatment of organic dye contaminants in wastewaters has now becoming more imperative. Fenton-like degradation of methylene blue (MB) and methyl orange (MO) in aqueous solution was investigated by using a nanostructure that a layer of CuCl2 nanoflake film grown on the top surface of nanoporus anodic alumina substrate (nano-PAA-CuCl2) as catalyst. The new nano-PAA-CuCl2 composite was fabricated with self-assembly approach, that is, a network porous structure film composed of CuCl2 nanoflake grown on the upper surface of nanoporous anodic alumina substrate, and the physical and chemical properties are characterized systematically with the X-ray diffraction (XRD), field emission scanning electron microscope (FE-SEM), and high-resolution transmission electron microscopy (HRTEM), Energy Dispersive Spectrometer (EDS), X-ray photoelectron spectroscopy (XPS). The experimental results showed that the nano-PAA-CuCl2 catalyst presented excellent properties for the degradation of two typical organic pollutants such as MB and MO, which were almost completely degraded with 8 × 10−4mol/L nano-PAA-CuCl2 catalyst after 46 min and 60 min at reaction conditions of H2O2 18 mM and 23 mM, respectively. The effects of different reaction parameters such as initial pH, H2O2 concentration, catalyst morphology and temperature were attentively studied. And more, the stability and reusability of nano-PAA-CuCl2 were examined. Finally, the mechanism of MB and MO degradation by the nano-PAA-CuCl2/H2O2 system was proposed, based on the experimental data of the BCA and the temperature-programmed reduction (H2-TPR) and theoretical analysis, the reaction kinetics belonged to the pseudo-first-order equation. This new nanoporous composite material and preparation technology, as well as its application in Fenton-like reaction, provide an effective alternative method with practical application significance for wastewater treatment.
Experimental and Kinetic Study on the Production of Furfural and HMF from Glucose
Authors: He Ouwen , Zhang Yangfan , Wang Pan , Liu Lina , Wang Qian , Yang Nan , Li Wenjie , Champagne Pascale , Yu Hongbing
Published: December 2020

Furfural and 5-hydroxymethylfurfural (HMF) have been identified as promising bio-platform furans that have a wide range of potential applications as biofuels, bioplastics, and biochemicals. Furfural and HMF are typically synthesized from the substrates of C5 sugars and C6 sugars, respectively. Furfural can also be produced from C6 sugars, which is technically more challenging owing to the higher energy requirement for carbon–carbon bond cleavage. In this study, the simultaneous production of furfural and HMF from glucose was conducted over different binary catalyst systems of Brønsted acids and Lewis acids using γ-valerolactone (GVL) as the solvent. A promising performance was achieved by a SnSO4-H2SO4 coupling catalyst, with an optimized furfural yield of 42% and an HMF yield of 34% at 443 K in GVL. In addition, a kinetics study was performed in order to understand the mechanism of the simultaneous formation of furfural and HMF from glucose at different temperatures and GVL/water ratios. The results showed that the ratio of furfural to HMF production rate at different temperatures (433 to 463 K) or GVL/water ratios (90 to 80%) was constant close to 1, suggesting that the production of furfural and HMF might follow similar reaction pathways. Finally, the reaction pathway of glucose conversion to furfural and HMF was proposed based on the experimental and kinetics studies.
A Retrospective Comparative Study of Sodium Fluoride (NaF-18)-PET/CT and Fluorocholine (F-18-CH) PET/CT in the Evaluation of Skeletal Metastases in Metastatic Prostate Cancer Using a Volumetric 3-D Radiomics Analysis
Authors: Kairemo Kalevi , Kappadath S. Cheenu , Joensuu Timo , Macapinlac Homer A.
Published: December 2020

Bone metastases are common in prostate cancer (PCa). Fluorocholine-18 (FCH) and sodium fluoride-18 (NaF) have been used to assess PCa associated skeletal disease in thousands of patients by demonstrating different mechanism of uptake-cell membrane (lipid) synthesis and bone mineralization. Here, this difference is characterized quantitatively in detail. Our study cohort consisted of 12 patients with advanced disease (> 5 lesions) (M) and of five PCa patients with no skeletal disease (N). They had routine PET/CT with FCH and NaF on consecutive days. Skeletal regions in CT were used to co-register the two PET/CT scans. Bone 3-D volume of interest (VOI) was defined on the CT of PET with a threshold of HU > 150, and sclerotic/dense bone as HU > 600, respectively. Additional VOIs were defined on PET uptake with the threshold values on both FCH (SUV > 3.5) and NaF (SUV > 10). The pathologic skeletal volumes for each technique (CT, HU > 600), NaF (SUV > 10) and FCH (SUV > 3.5) were developed and analyzed. The skeletal VOIs varied from 5.03 L to 7.31 L, whereas sclerotic bone VOIs were from 0.88 L to 2.99 L. Total choline kinase (cell membrane synthesis) activity for FCH (TCA) varied from 0.008 to 4.85 [kg] in M group and from 0.0006 to 0.085 [kg] in N group. Total accelerated osteoblastic (bone demineralization) activity for NaF (TBA varied from 0.25 to 13.6 [kg] in M group and varied from 0.000 to 1.09 [kg] in N group. The sclerotic bone volume represented only 1.86 ± 1.71% of the pathologic FCH volume and 4.07 ± 3.21% of the pathologic NaF volume in M group, and only 0.08 ± 0.09% and 0.18 ± 0.19% in N group, respectively. Our results suggest that CT alone cannot be used for the assessment of the extent of active metastatic skeletal disease in PCa. NaF and FCH give complementary information about the activity of the skeletal disease, improving diagnosis and disease staging.
Development of a Portable, Reliable and Low-Cost Electrical Impedance Tomography System Using an Embedded System
Authors: Zamora-Arellano Francisco , López-Bonilla Oscar Roberto , García-Guerrero Enrique Efrén , Olguín-Tiznado Jesús Everardo , Inzunza-González Everardo , López-Mancilla Didier , Tlelo-Cuautle Esteban
Published: December 2020

Electrical impedance tomography (EIT) is a useful procedure with applications in industry and medicine, particularly in the lungs and brain area. In this paper, the development of a portable, reliable and low-cost EIT system for image reconstruction by using an embedded system (ES) is introduced herein. The novelty of this article is the hardware development of a complete low-cost EIT system, as well as three simple and efficient algorithms that can be implemented on ES. The proposed EIT system applies the adjacent voltage method, starting with an impedance acquisition stage that sends data to a Raspberry Pi 4 (RPi4) as ES. To perform the image reconstruction, a user interface was developed by using GNU Octave for RPi4 and the EIDORS library. A statistical analysis is performed to determine the best average value from the samples measured by using an analog-to-digital converter (ADC) with a capacity of 30 kSPS and 24-bit resolution. The tests for the proposed EIT system were performed using materials such as metal, glass and an orange to simulate its application in food industry. Experimental results show that the statistical median is more accurate with respect to the real voltage measurement; however, it represents a higher computational cost. Therefore, the mean is calculated and improved by discarding data values in a transitory state, achieving better accuracy than the median to determine the real voltage value, enhancing the quality of the reconstructed images. A performance comparison between a personal computer (PC) and RPi4 is presented. The proposed EIT system offers an excellent cost-benefit ratio with respect to a traditional PC, taking into account precision, accuracy, energy consumption, price, light weight, size, portability and reliability. The proposed EIT system has potential application in mechanical ventilation, food industry and structural health monitoring.
2030 Target for Energy Efficiency and Emission Reduction in the EU Paper Industry
Authors: Li Shuangjie , Li Li , Wang Liming
Published: December 2020

Improving energy efficiency is an effective way to address the issues of economic development, energy saving and emissions reduction. For any important industries it is therefore necessary to measure energy efficiency and set a practical target for it. In this paper, we use CCR, SBM and energy intensity to measure the energy efficiency of the paper industries of 22 EU countries. Results indicate that the SBM and CCR efficiency value is more meaningful for policy makers than that of energy intensity, as measurement results of energy intensity deviate from reality and economic efficiency. The CCR and SBM have roughly the same fluctuation trends and the average SBM energy efficiency value is 0.71, always 10 percent lower than CCR model, as it takes simultaneous account of both the optimal input-output and has more discriminatory power in efficiency measurement. Furthermore, EU policy makers could improve energy efficiency by raising energy prices. As for the 2030 EU target of energy saving and emission reduction, the EU should pay more attention to five major paper producers: Finland, Sweden, Germany, the United Kingdom and Italy.
MYC DNA Methylation in Prostate Tumor Tissue is Associated with Gleason Score
Authors: Barry Kathryn Hughes , Mohanty Kareshma , Erickson Patricia A. , Wang Difei , Shi Jianxin , Rose Gary , Cellini Ashley , Clark Kimberly , Ambulos Nicholas , Yin Jing , Yan Liying , Poulin Matthew , Meyer Ann , Zhang Yuji , Bentzen Søren M. , Burke Allen , Hussain Arif , Berndt Sonja I.
Published: December 2020

Increasing evidence suggests a role of epigenetic mechanisms at chromosome 8q24, an important cancer genetic susceptibility region, in prostate cancer. We investigated whether MYC DNA methylation at 8q24 (six CpG sites from exon 3 to the 3′ UTR) in prostate tumor was associated with tumor aggressiveness (based on Gleason score, GS), and we incorporated RNA expression data to investigate the function. We accessed radical prostatectomy tissue for 50 Caucasian and 50 African American prostate cancer patients at the University of Maryland Medical Center, selecting an equal number of GS 6 and GS 7 cases per group. MYC DNA methylation was lower in tumor than paired normal prostate tissue for all six CpG sites (median difference: −14.74 to −0.20 percentage points), and we observed similar results for two nearby sites in The Cancer Genome Atlas (p < 0.0001). We observed significantly lower methylation for more aggressive (GS 7) than less aggressive (GS 6) tumors for three exon 3 sites (for CpG 212 (chr8:128753145), GS 6 median = 89.7%; GS 7 median = 85.8%; p-value = 9.4 × 10−4). MYC DNA methylation was not associated with MYC expression, but was inversely associated with PRNCR1 expression after multiple comparison adjustment (q-value = 0.04). Findings suggest that prostate tumor MYC exon 3 hypomethylation is associated with increased aggressiveness.
Physical Activity Recommendations during COVID-19: Narrative Review
Authors: Polero Patricia , Rebollo-Seco Carmen , Adsuar José C. , Pérez-Gómez Jorge , Rojo-Ramos Jorge , Manzano-Redondo Fernando , Garcia-Gordillo Miguel Ángel , Carlos-Vivas Jorge
Published: December 2020

Regular practice of physical activity plays a fundamental role in preventing and treating cardiovascular diseases such as obesity, hypertension, diabetes, and metabolic syndrome. During the pandemic caused by COVID-19 and the lockdown established, people have reduced considerably their mobility and motor activity, which has led to an increase in unhealthy lifestyle habits, raising the risk of suffering from diseases. This paper consists of reviewing the existing scientific literature on recommendations of physical activity during the pandemic and to establish specific guidelines according to the type of population to which the activity would be directed. A search strategy has been carried out in the different databases: Embase, PubMed, SCOPUS, SPORTDiscus, and Web of Science (WoS), including all the articles published until 14 May 2020, to find essays with recommendations on aerobic activity, muscle strengthening, flexibility-stretching, meditation-relaxation, and balance exercises. The articles found have been evaluated considering the following criteria: type of publication, proposals for physical exercise, language, and, if it appears, volume of activity, frequency, intensity, and rest. The results obtained 29 articles that discuss patterns of physical activity, although there is no common consensus on such recommendations during confinement, nor are they suitable for all people. From these results, we can conclude that physical activity is widely recommended during the confinement caused by COVID-19, mainly through the performance of aerobic, strength, flexibility, and balance exercises.
The Impact of Illegal Waste Sites on the Transmission of Zoonotic Cutaneous Leishmaniasis in Central Tunisia
Authors: Chelbi Ifhem , Mathlouthi Olfa , Zhioua Sami , Fares Wasfi , Boujaama Anis , Cherni Saifedine , Barhoumi Walid , Dachraoui Khalil , Derbali Mohamed , Abbass Mohamed , Zhioua Elyes
Published: December 2020

Illegal waste disposal represents a risk health factor for vector-borne diseases by providing shelter for rodents and their ectoparasites. The presence of the Phlebotomus papatasi vector of Leishmania major, an etiologic agent of zoonotic cutaneous leishmaniasis (ZCL), was assessed at illegal waste sites located at the vicinity of villages in endemic areas of Central Tunisia. The study was performed over a two-year period over three nights from July to September 2017, and over three nights in September 2018. Household waste is deposited illegally forming dumpsites at the vicinity of each village and contains several rodent burrows of Psammomys obesus, the main reservoir host of L. major. Sandflies were collected from rodent burrows in the natural environment and in dumpsites using sticky traps and were identified at species level. Female sandflies were tested for the presence of L. major by PCR. Our entomological survey showed that Phlebotomus papatasi is the most abundant sandfly species associated with rodent burrows in these waste sites. The densities of P. papatasi in dumpsites are significantly higher compared to the natural environment. The minimum infection rate of P. papatasi with L. major in these illegal waste sites is not significantly different compared to the natural environment. Considering the short flight range of P. papatasi, increases in its densities, associated with burrows of P. obesus in illegal waste sites located at the edge of villages, expands the overlap of infected ZCL vectors with communities. Thus, illegal waste sites pose a high risk of spreading ZCL to neighboring home ranges. Waste management is an environmentally friendly method of controlling sandfly populations and should be included in an integrated management program for controlling ZCL in endemic countries.
Chewing Discomfort According to Dental Prosthesis Type in 12,802 Adults: A Cross-Sectional Study
Authors: Lee Jae-Hyun , Kim Da Hye , Park Yong-Gyu , Lee Su Young
Published: December 2020

This study examined the prevalence of self-perceived chewing discomfort depending on the type of dental prosthesis used in South Korean adults. The subjects were 12,802 people over 20 years of age who participated in a health interview and dental examination. Chewing discomfort was examined using a self-assessed report with a structured questionnaire. Using multivariable logistic regression analysis, adjusted odds ratios were evaluated along with their 95% confidence intervals (α = 0.05). After adjusting for covariates, including age, gender, smoking, drinking, hypertension, diabetes, body mass index, education, income, and toothbrushing frequency, the odds ratios (95% confidence intervals) for chewing discomfort in groups without a dental prosthesis, with fixed dental prostheses, with removable partial dentures, and with removable complete dentures were 1 (reference), 1.363 (1.213–1.532), 2.275 (1.879–2.753), and 2.483 (1.929–3.197), respectively. The association between the prevalence of chewing discomfort and the type of dental prosthesis used was statistically significant even after adjusting for various confounders (p < 0.0001). The type of dental prosthesis was related to chewing discomfort among South Korean adults.
Cognitive and Learning Outcomes in Late Preterm Infants at School Age: A Systematic Review
Authors: Martínez-Nadal Sílvia , Bosch Laura
Published: December 2020

Late preterm children born between 340/7 and 366/7 weeks’ gestation account for ≈70% of prematurely born infants. There is growing concern about this population at risk of mild neurodevelopmental problems, learning disabilities and lower academic performance. Following the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) statement, this paper analyzes recent published evidence from 16selected studies involving late preterm children and control group assessments at preschool and/or school age, mainly focusing on cognitive functioning, language learning and academic achievement. The review identifies the assessment tools used in these studies (standardized tests, parental questionnaires and laboratory tasks) and the areas being evaluated from preschool (age 3 years) to primary school levels. Results reveal the presence of mild difficulties, pointing to suboptimal outcomes in areas such as executive function, short term verbal memory, literacy skills, attention and processing speed. Some difficulties are transient, but others persist, possibly compromising academic achievement, as suggested by the few studies reporting on higher risk for poor school performance. Given the increasing number of late preterm children in our society the review highlights the need to implement screening strategies to facilitate early risk detection and minimize the negative effects of this morbidity in childhood.