bluuebunny/crossref_metadata_2025 huggingface dataset:
Fractional integral formulae concerning certain special functions
Authors: Chaurasia V.B.L. , Parihar Hari Singh
Published: May 2019

The main aim of the present paper is to derive some results related to fractional integral formulae on the product of multivariable $H$-function and two general class of multivariable polynomials. A large number of known and new result have also been obtained by proper choice of parameters.
Unsteady free covection oscillatory couette flow through a porous medium with periodic wall temperature
Authors: Sharma P. Kumar , Sharma B. Kumar , Chaudhary R. C.
Published: May 2019

This communication investigates the effect of free convection on the heat transfer and the flow through a highly porous medium bounded by two vertical parallel porous plates. It is assume that free stream velocity oscillates

in times about a constant mean. Assuming periodic temperature at the moving plate, the approximate solutions for velocity field, emperature field, skin-friction and the rate of heat transfer are obtained and discussed with the help of graphs and tables.
Representations of complete regular local noether lattices
Authors: Johnson E. W. , Johnson Johnny A.
Published: May 2019

In this paper, we prove the uniqueness of the the ring of representation for any complete regular local Noether lattice. We investigate conditions for representability and obtain a form of necessary and sufficient condition.
Invariant approximations, generalized I-non- expansive mappings and non-convex domain
Authors: Nashine Hemant Kumar
Published: May 2019

Common fixed point results for generalized I-nonexpansive mappings, and nonlin-ear map on nonstarshaped domain have been obtained in the present work. Various invariant approximation results have also been determined by its application. These results extend and generalize various existing known results in the literature. A property called property;
also been introduced in it.
Detection of a new nontrivial family in the stable homotopy of spheres $ \mbf{\pi_{\ast}S} $
Authors: Xiugui Liu , Yinglong Jin
Published: May 2019

To determine the stable homotopy groups of spheres is one of the central problems in homotopy theory. Let $ A $ be the mod $ p $ Steenrod algebra and $S$ the sphere spectrum localized at an odd prime $ p $. In this article, it is proved that for $ p\geqslant 7 $, $ n\geqslant 4 $ and $ 3\leqslant s $, $ b_0 h_1 h_n \tilde{\gamma}_{s} \in Ext_A^{s+4,\ast}(\mathbb{Z}_p,\mathbb{Z}_p) $ is a permanent cycle in the Adams spectral sequence and converges to a nontrivial element of order $ p $ in the stable homotopy groups of spheres $ \pi_{p^nq+sp^{2}q+(s+1)pq+(s-2)q-7}S $, where $ q=2(p-1 ) $.
Physical-chemical monitoring of the Linhares (ES) and São Mateus (ES) aquatic ecosystem after the breaking of the Fundão Dam, Mariana, Minas Gerais
Authors: Silva Cleber Vinicius Vitorio , Almeida Josimar Ribeiro de , Silva Carlos Eduardo , Carvalho Lyanna Oliveira de , Silva Carlos Domingos da
Published: May 2019

On November 5, 2015, the rupture occurred of the Fundão dam of the mining company Samarco, located in the sub-district of Bento Rodrigues-MG, 35 km from the center of the Brazilian municipality of Mariana-MG, approximately 16.000 Olympic pools of mining residue circulated through the district of Bento Rodrigues in a period of only 11 minutes. The plume of this environmental impact extended approximately 800 km in the Rio Doce basin, between Minas Gerais and Espirito Santo. The Ipiranga river, located between Linhares and São Mateus, was one of the last sites affected by the waste from the Doce river basin, having contact with the sea in the Urussuquara-ES restinga, a place that is a nursery of biodiversity, especially the marine and estuarine ichthyofauna, besides being of great importance for artisanal fishing and ecotourism. The present study aimed to monitor the Ipiranga River and Urussuquara Beach for all seasonal seasons, beginning in September 2017 and ending in May 2018, the following variables were analyzed: dissolved oxygen, electrical conductivity, hydrogenation potential (pH), transparent, temperature, depth and total dissolved solids, comparing them to the Resolution CONAMA n°. 357, de 17/03/2005, with the purpose of evaluating the quality of estuarine and marine waters. The results found were alarming and evident foci of negative impacts on the aquatic ecosystem and society dependent on artisanal fishing for their subsistence.
Biodiversity of bulbous and tuberous geophytes from the El Kala National Park (North-Eastern Algeria): checklist, vulnerability and conservation
Authors: Dechir Besma , Chouikh Atef , Hamel Tarek , Azizi Nawel Nadia , Ganaoui Nawel , Grira AbdSlem , Abdiouene Ahmed , Maazi Mohamed Cherif , Chefrour Azzedine
Published: May 2019

Treinta estaciones en el Parque Nacional El Kala (Noreste de Argelia) fueron objeto de un inventario florístico que se centró en el estudio de la ecología de geófitos bulbosos y tuberosos. La flora se caracteriza por una alta proporción de taxones raros y/o endémicos, entre ellos, 6 especies son endemismos algero-tunecinos pertenecientes a la familia Orchidaceae. En este trabajo, se da a conocer la presencia de una nueva especie para la flora argelina, Ophrys fusca subsp. lupercalis. Los análisis multivariantes revelaron, ciertas variables ambientales que determinan la distribución de los geófitos. Los lugares de interés son particularmente sensibles a las amenazas, particularmente las de origen antrópico.

Thirty stations at the El Kala National Park (North Eastern Algeria) were the subject of a floristic focused on the study of the ecology of bulbous and tuberous geophytes. The floristic analysis was used to draw up a checklist of 67 species belonging to 36 genera and 14 families, among of which 19 species a high proportion of rare and/or endemic taxa; among them six signed taxa are endemic to algerian-tunisian mainly represented by family of Orchidaceae. In this work, we recorded the presence of a new species for the Algerian flora which is Ophrys fusca subsp. lupercalis. Multivariate analyses revealed certain environmental variables determining the distribution of geophytes. The visited sites show an alarming vulnerability and subject to threats, particularly anthropogenic ones.
Exploring the links between tourism and quality of institutions
Authors: Buitrago Esquinas Eva Mª , Caraballo Pou Mª Ángeles
Published: May 2019

This paper introduces a new perspective on the impacts of tourism on host communities by analyzing the links between tourism specialization and quality of institutions. Our research has two principal aims: firstly, to test the significance and sign of this relationship; and secondly, to explore the channels through which tourism could affect institutional quality. To this end, an econometric analysis is conducted using a sample of 92 countries over the period 1995-2014. The results indicate that there is a significant and positive association between tourism specialization and institutional quality. Moreover, this relation can be explained through three main channels: level of income, income inequality, and economic freedom.

Este trabajo aporta una nueva perspectiva sobre los impactos del turismo analizando las relaciones entre la especialización turística de un país y la calidad de sus instituciones. La investigación plantea dos objetivos: (1) testar empíricamente la significatividad y signo de dichas relaciones y (2) explorar los canales a través de los que se producen. Realizamos un análisis econométrico para 92 países y 20 años. Los principales resultados indican la existencia de una asociación significativa y positiva entre turismo y calidad institucional que se produce principalmente a través de tres canales: nivel de renta, distribución de la renta y libertad económica.
La actividad comercial en empresas turísticas. Percepción de los estudiantes de turismo
Authors: Canales Ronda Pedro , Hernández Fernández Asunción
Published: May 2019

El presente trabajo pretende analizar la opinión que los estudiantes universitarios de Turismo tienen respecto a desarrollar su futuro laboral en el área comercial de empresas turísticas, la que más oferta de puestos de trabajo genera en España. En concreto, se pretende conocer cuál es su percepción sobre este tipo de trabajo, tanto desde un punto de vista personal como profesional. Para alcanzar estos objetivos, se ha encuestado a 348 estudiantes de diferentes cursos, de grado y posgrado, que han sido clasificados en función de su interés por trabajar como vendedores en el sector turístico. Los resultados muestran que, en general, la valoración de una futura actividad de tipo comercial es positiva.

The current research intends to analyze the opinion that the tourism university students have regarding to develop their future labor in the commercial management area of tourist companies, the one that more offer of jobs generates in Spain. Specifically, we want to know what the perception of this type of work is, both from a personal and professional point of view. To achieve these objectives, 348 students, from different undergraduate and postgraduate courses, have been surveyed, who have been classified according to their interest in working as sellers in the tourism sector. The results show that, in general, the valuation of a future commercial activity is positive.
Relevancia y desafíos del paisaje en la formación de una imagen turística de prestigio: la Costa de Llanes (Asturias)
Authors: Sevilla Álvarez Juan , Rodríguez Pérez Carmen
Published: May 2019

La costa de Llanes (oriente de Asturias), enmarcada por el mar Cantábrico y la media montaña de la Sierra del Cuera (apenas separados por 8 kilómetros), presenta rasgos paisajísticos singulares que han incentivado las visitas turísticas desde hace ya más de un siglo. Se trata de un espacio marcado por la trascendencia de los condicionantes naturales pero transformado en época reciente por la presión turística. En este trabajo se analiza el papel del paisaje en el desarrollo turístico, desde una perspectiva histórica, y se indaga en la capacidad de la propia actividad turística para transformar ese paisaje que, en origen, constituye un factor de atracción esencial. Siguiendo este cometido, se atiende a la evolución histórica de la divulgación del paisaje y se valoran los planteamientos de las acciones institucionales en lo relativo a la ordenación sectorial y territorial integral a distintas escalas.

The coast of Llanes, framed by the Cantabrian Sea and Sierra del Cuera mountains (barely separated by 8 kilometers), contains unique landscape elements that have stimulated tourist visits for more than a century. It is a space marked by the transcendence of natural conditions but transformed in recent times by tourist pressure. This paper analyzes the role of landscape in tourism development, from a historical perspective, and the ability of tourism itself to transform this landscape that, in origin, constitutes an essential factor of attraction. The historical evolution of landscape knowledge dissemination is presented as well as the approaches of institutional actions in sectoral and integral spatial planning at different scales.
Evaluación de la percepción de congestión del turista en el centro histórico de Quito
Authors: Torres Matovelle Pablo , Tapia López Jesús , Suquilanda Agila Karla
Published: May 2019

La congestión es un fenómeno que preocupa desde hace décadas a los gestores de destinos turísticos. Pocos estudios se han desarrollado para evaluarla en ciudades patrimoniales sobre todo a partir de la percepción del turista, notando un escaso tratamiento del tema en Latinoamérica. Esta investigación evalúa la percepción de congestión del turista en el Centro Histórico de Quito, mediante aportes metodológicos que vinculan variables de tipo motivacional, emocional y conductual. Los resultados indican que la percepción de congestión es percibida mayoritariamente entre leve y moderada.

Crowding is a phenomenon that has worried managers of tourist destinations for decades. Few studies have been developed to evaluate it in heritage cities from the perception of the visitor, noticing a poor treatment of the subject in Latin America. This research evaluates the tourist crowding perception in the Historic Center of Quito, through methodological contributions that link motivational, emotional and behavioral variables. The results indicate that crowding is perceived mostly between mild and moderate.
pyLLE: A Fast and User Friendly Lugiato-Lefever Equation Solver
Authors: Moille Gregory , Li Qing , Xiyuan Lu , Srinivasan Kartik
Published: May 2019

The Lugiato-Lefever Equation (LLE), first developed to provide a description of
spatial dissipative structures in optical systems, has recently made a significant
impact in the integrated photonics community, where it has been adopted to help
understand and predict Kerr-mediated nonlinear optical phenomena such as parametric
frequency comb generation inside microresonators. The LLE is essentially an
application of the nonlinear Schrodinger equation (NLSE) to a damped, driven Kerr
nonlinear resonator, so that a periodic boundary condition is applied. Importantly,
a slow-varying time envelope is stipulated, resulting in a mean-field solution in
which the field does not vary within a round trip. This constraint, which
differentiates the LLE from the more general Ikeda map, significantly simplifies
calculations while still providing excellent physical representation for a wide
variety of systems. In particular, simulations based on the LLE formalism have
enabled modeling that quantitatively agrees with reported experimental results on
microcomb generation (e.g., in terms of spectral bandwidth), and have also been
central to theoretical studies that have provided better insight into novel
nonlinear dynamics that can be supported by Kerr nonlinear microresonators. The
great potential of microresonator frequency combs (microcombs) in a wide variety of
applications suggests the need for efficient and widely accessible computational
tools to more rapidly further their development. Although LLE simulations are
commonly performed by research groups working in the field, to our knowledge no free
software package for solving this equation in an easy and fast way is currently
available. Here, we introduce pyLLE, an open-source LLE solver for microcomb
modeling. It combines the user-friendliness of the Python programming language and
the computational power of the Julia programming language.
The effect of knowledge-centered culture and social interaction on organizational innovation: the mediating effect of knowledge management
Authors: Fierro Moreno Eréndira , Mercado Salgado Patricia , Cernas Ortíz Daniel Arturo
Published: May 2019

The effect of organizational resources in technological innovation has been widely studied. However, the effect of these resources in organizational innovation is a subject that still requires greater scrutiny. Relying on the resource-based view of the firm, we hypothesize that the knowledge-centered culture and the social interaction are factors (resources) that affect the organizational innovation, but that this effect is mediated by the knowledge management. Using a transversal study with a sample ofMexican public hospitals through its high and medium level managers perception we found support for the hypotheses. Results of the research confirm the importance of a knowledge-centered culture, social interaction, and knowledge management as predictors of organizational innovation. This study also buttresses the critical role of knowledge management as a mediating variable in the influence of a variety of factors on the development of organizational capabilities.

Keywords: Organizational innovation, knowledge management, organizational resources.
The importance of market intelligence in spanish firms’ exporting activity
Authors: Navarro-García Antonio , Peris-Ortiz Marta , Barrera-Barrera Ramón , Villarejo-Ramos Ángel Francisco
Published: May 2019

This research aims to respond to a research gap in the literature concerning the role of market intelligence in export activity. In particular, we examine the effects of market intelligence on the interrelationships between market distances (domestic vs. foreign) perceived by export managers, strategic marketing mix decisions (standardisation vs. adaptation) and export performance (growth in foreign sales and satisfaction). The results of an empirical study using data from a sample of 212 Spanish exporters reveal that: (a) strategic decisions aimed at adapting the marketing mix to foreign markets have a positive effect on export performance, (b) market distances associated with economic, legal, social, and cultural differences between Spain and overseas markets encourage conservative decision making, embodied in a standardised international marketing mix (similar to that used in Spain), (c) however, when export managers have relevant foreign market information and analyses, market intelligence processes reduce perceived market distances and encourage more proactive strategic behaviour (adaptation of the marketing mix), resulting in improved export performance.

Keywords: Market Intelligence, Perceived Market Distances, Marketing Mix Adaptation, Export Performance.
Gender differences in entrepreneurial orientation
Authors: Reyes Recio Luisa Eugenia , Pinillos Costa María José , Soriano Pinar Isabel
Published: May 2019

The following paper aims to analyze gender differences in entrepreneurial orientation. Based on the model of entrepreneurship orientation for the intrapreneurship, we have analyzed the proactivity, creativity, innovation and risk propensity as variables that capture the profile of the individual entrepreneur in the pre-stage company.
To perform the analysis we have selected a sample of students from the Universidad Rey Juan Carlos who attended extracurricular seminars on “Entrepreneurship and Leadership”. The study of gender difference has been made by a study of mean differences and a classification study by the method of discriminant analysis.
The results not only indicate that there are significant differences in entrepreneurial behavior due to gender differences, but also the study of the group classification confirms the existence of distinct groups associated with gender. Specifically, the feminine gender is more risk averse and is considered less innovative. However, regarding proactivity, the feminine gender is associated more to attributes relating to responsibility, discipline and independence, and the masculine to initiative and leadership positions.
Keywords: Gender, entrepreneurial behavior, study of attitudes, entrepreneurship.
Entrepreneurship by women in the rural environment: tourism as a spur to development
Authors: Talón Ballestero Pilar , Abad Romero Pilar , González Serrano Lydia
Published: May 2019

The important role of women in rural development has been brought repeatedly to notice
in the literature, but the role of women entrepreneurs in rural development is a more novel
issue. Rural tourism has provided a fundamental opportunity for women to join the job
market and earn recognition of their economic independence and professional status, but
little evidence exists of the real impact of rural tourism businesses run by women. The
objective of this research therefore is to evaluate the economic situation of women rural
tourism entrepreneurs, determining what variables affect the probability that a woman
owner or manager will earn her basic or fundamental income from running tourist accommodation
(a country cottage). The results confirm that running rural tourist accommodation
normally brings in supplementary income, although the rural environment seems
to be witnessing the rise of a new profile in female entrepreneurs, where there is less
dependence on the traditional family structure and greater proximity to both personal
and economic independence.
Keywords: Women, entrepreneurship, rural tourism, rural development, profile of women
entrepreneurs, logit model.
The distinctive attributes of lodging management from the standpoint of the entrepreneur’s gender: an application to boutique hotels in Spain
Authors: Fuentas-Moraleda Laura , Villacé Molinero Teresa , Muñoz Mazón Ana
Published: May 2019

Studies on the characteristics of women as entrepreneurs confirm that women’s managerial
style is different from men’s. In the tourism industry, and more specifically in the
boutique hotel sector, these differences are important, due to the intrinsic characteristics of
boutique establishments. This paper identifies the distinctive attributes of boutique hotels
and examines how those attributes are managed by entrepreneurs of different genders.
Qualitative work sets the groundwork by ascertaining what attributes the boutique hotel
clientele demands; this is followed by quantitative work to ascertain how the attributes
in question are distributed among the leading management factors of the members of a
charming lodging club in Spain. The results confirm that the composition of the factors
managed in boutique hotels differs depending on whether women or men are in charge,
and this difference gives women a closer rapport with the philosophy implicit in boutique
hotels.
Keywords: Entrepreneurs, gender, attributes, boutique hotels, management.
Women, entrepreneurship and creative cultural industries: a combination on the rise
in Spain in times of crisis
Authors: Laguna Sánchez Pilar , Vico Belmonte Ana , Palomo-Martínez Jesús
Published: May 2019

Creative cultural industries are businesses on the rise with a potential that has yet to
be determined. They are not generally acknowledged by the State as economic pursuits,
however. The notion that culture is a not-for-profit endeavour is firmly rooted in Spanish
society, a circumstance that has led to the invisibility of the industry as a business
opportunity.
That lack of credibility as an economic proposition is reinforced by the industry’s organisation
and management, its dependence on subsidies and its focus more on propagation
than industrialisation. It consequently lacks both strategic business and sex equality
policies.
Keywords: Women, entrepreneurship, culture, creative cultural industries, SMEs, cultural
development.
Evolution of marketing in higher education: Educational brand capital
Authors: Casanoves-Boix Javier , Kuster-Boluda Inés
Published: May 2019

This research was carried out to examine the role of brand capital in higher education. Firstly, the main contributions of the literature related to the study of brand capital and its application to the educational sector were analyzed. In this way, the variables that determine brand capital in higher education were identified, establishing a view of it as an evolutionary process. Through the present work, the evolution of higher education was analyzed together with the importance of the application of marketing strategies adapted to obtain differentiation and competitive advantage through educational brand capital. This was carried out in order to highlight the importance it is acquiring and, likewise, to identify the promising future perspectives that it can offer to the industry.
Keywords: brand, brand capital, higher education.
The influence of museums’ websites on users’ intentions
Authors: García-Madariaga Jesús , Recuero Virto Nuria , Blasco López Francisca
Published: May 2019

This study confirms that museums’ website features – content, made for the medium, ease of use, promotion, emotion and aesthetics – positively and significantly influence users’ intentions of revisiting the website and visiting of it physically.
This research empirically tests a model in two museum’s websites, namely the Prado Museum and the Reina Sofia Museum. Using Partial Least Squares-based Multi-Group analysis (PLS-MGA), it was proved that satisfaction does not have a significant effect on intentions in the case of Prado Museum. The research confirmed that overall, website evaluation positively and significantly influences users’ perception of their control within the website and their intentions. The findings reveal significant academic and managerial contributions. The PLS-MGA results demonstrate that there are no significant differences between the two museums.
Keywords: museum, website, intentions, control, satisfaction.
Model for the management of trade brands: a theoretical approach based on the General System?s Theory
Authors: Martín García Manuel , Bermúdez González Guillermo , Li Zhenxing , Parra Guerrero Francisca
Published: May 2019

This article presents a Systemic Model of management for trade brands based on the contributions derived conceptual and empirical literature. The aim is to analyse the previous analyses and to propose a series of hypotheses that demonstrate the interrelationship between the considered essential elements in the process of brands’ building. Results have been obtained by means of a qualitative analysis that has led to the identification of four essential dimensions in the process of brands’ management: Identity, positioning, formal image and communication. The proposed model is a useful tool to manage in a rigorous way the processes of brands’ creation and audit.

Keywords: brand, identity, image, positioning, brand equity.
CAM: An alignment-free method to recover phylogenies using codon aversion motifs
Authors: Miller Justin B , McKinnon Lauren M , Whiting Michael F , Ridge Perry G
Published: May 2019

Background. Common phylogenomic approaches for recovering phylogenies are often time-consuming and require annotations for orthologous gene relationships that are not always available. In contrast, alignment-free phylogenomic approaches typically use structure and oligomer frequencies to calculate pairwise distances between species. We have developed an algorithm to quickly calculate distances between species based on codon aversion.

Methods. Utilizing a novel alignment-free character state, we present CAM, an alignment-free approach to recover phylogenies by comparing differences in codon aversion motifs (i.e., the set of unused codons within each gene) across all genes within a species. Synonymous codon usage is non-random and differs between organisms, between genes, and even within a single gene, where many genes do not use all possible codons. We report a comprehensive analysis of codon aversion within 229 742 339 genes from 23 428 species across all kingdoms of life, and we provide an alignment-free framework for its use in a phylogenetic construct. For each species, we first construct a set of codon aversion motifs spanning all genes within that species. We define the pairwise distance between two species, A and B, as one minus the number of shared codon aversion motifs divided by the total codon aversion motifs of the species, A or B, containing the fewest motifs. This approach allows us to calculate pairwise distances even when substantial differences in the number of genes or a high rate of divergence between species exists. Finally, we use neighbor-joining to recover phylogenies.

Results. Using the Open Tree of Life and NCBI Taxonomy Database as expected phylogenies, our approach compares well, recovering phylogenies that largely match expected trees and are comparable to trees recovered using maximum likelihood and other alignment-free approaches. Our technique is much faster than maximum likelihood and similar in accuracy to other alignment-free approaches. Therefore, we propose that codon aversion be considered a phylogenetically conserved character that may be used in future phylogenomic studies.

Availability. CAM, documentation, and test files are freely available on GitHub at https://github.com/ridgelab/cam
Seismic stratigraphy of the broad, low-gradient continental shelf of the Palaeo-Agulhas Plain, South Africa
Authors: Cawthra Hayley C , Frenzel Peter , Hahn Annette , Compton John , Gander Lukas , Zabel Matthias
Published: May 2019

The continental shelf of the Palaeo-Agulhas Plain (PAP) is scattered with Pleistocene deposits with subdued topography. Their exaggerated lateral extension is the expression of a flat underlying substrate and availability of accommodation space, depositional processes and response to glacio-eustatic sea-level change have influenced deposition and distribution of these units. We present new results for the upper ~30 m (up to ~200 ka) of the stratigraphic record in this area and show that this shelf offers the opportunity to examine the response of a stable tectonic setting to the effects of sea-level change. This paper presents the results of extensive sub-bottom profiling surveys and chronostratigraphic investigations from marine sediment vibracores. Radiocarbon and Optically stimulated Luminescence dates are integrated into a seismic stratigraphic model composed of twenty Quaternary units, where two depositional sequences are bounded by shelf-wide unconformities. The upper sequence was cored where Pleistocene deposits were observed to be close to the seafloor and are draped in a thin veneer of marine shelf sediment and allow us to describe the environments of deposition of the PAP. The most pervasive stratigraphic pattern in these shelf deposits is made up of the depositional sequence remnant of the Falling Stage Systems Tract (FSST) forced regression from Marine Isotope Stage 5e–2. The other dominant stratigraphic group is the Transgressive Systems Tract (TST) associated with the Postglacial Marine Transgression. Surprisingly, the TST makes up an almost equal proportion of deposits in both sequences in the sedimentological record as the FSST, despite the shorter temporal span of the TST. The sub-bottom profiles were acquired on regional surveys extending from the Breede River in the west to Plettenberg Bay in the east, and to a maximum depth of 110 m below Mean Sea Level, with the exception of one ~200 m deep shelf-edge profile.
Live-cell imaging reveals enhancer-dependent Sox2 transcription in the absence of enhancer proximity
Authors: Alexander Jeffrey M , Guan Juan , Li Bingkun , Maliskova Lenka , Song Michael , Shen Yin , Huang Bo , Lomvardas Stavros , Weiner Orion D
Published: May 2019

Enhancers are important regulatory elements that can control gene activity across vast genetic distances. However, the underlying nature of this regulation remains obscured because it has been difficult to observe in living cells. Here, we visualize the spatial organization and transcriptional output of the key pluripotency regulator Sox2 and its essential enhancer Sox2 Control Region (SCR) in living embryonic stem cells (ESCs). We find that Sox2 and SCR show no evidence of enhanced spatial proximity and that spatial dynamics of this pair is limited over tens of minutes. Sox2 transcription occurs in short, intermittent bursts in ESCs and, intriguingly, we find this activity demonstrates no association with enhancer proximity, suggesting that direct enhancer-promoter contacts do not drive contemporaneous Sox2 transcription. Our study establishes a framework for interrogation of enhancer function in living cells and supports an unexpected mechanism for enhancer control of Sox2 expression that uncouples transcription from enhancer proximity.
Comprehensive substrate specificity profiling of the human Nek kinome reveals unexpected signaling outputs
Authors: van de Kooij Bert , Creixell Pau , van Vlimmeren Anne , Joughin Brian A , Miller Chad J , Haider Nasir , Simpson Craig D , Linding Rune , Stambolic Vuk , Turk Benjamin E , Yaffe Michael B
Published: May 2019

Human NimA-related kinases (Neks) have multiple mitotic and non-mitotic functions, but few substrates are known. We systematically determined the phosphorylation-site motifs for the entire Nek kinase family, except for Nek11. While all Nek kinases strongly select for hydrophobic residues in the −3 position, the family separates into four distinct groups based on specificity for a serine versus threonine phospho-acceptor, and preference for basic or acidic residues in other positions. Unlike Nek1-Nek9, Nek10 is a dual-specificity kinase that efficiently phosphorylates itself and peptide substrates on serine and tyrosine, and its activity is enhanced by tyrosine auto-phosphorylation. Nek10 dual-specificity depends on residues in the HRD+2 and APE-4 positions that are uncommon in either serine/threonine or tyrosine kinases. Finally, we show that the phosphorylation-site motifs for the mitotic kinases Nek6, Nek7 and Nek9 are essentially identical to that of their upstream activator Plk1, suggesting that Nek6/7/9 function as phospho-motif amplifiers of Plk1 signaling.
Fragility Index, power, strength and robustness of findings in sports medicine and arthroscopic surgery: a secondary analysis of data from a study on use of the Fragility Index in sports surgery
Authors: Reito Aleksi , Raittio Lauri , Helminen Olli
Published: May 2019

Background

A recent study concluded that most findings reported as significant in sports medicine and arthroscopic surgery are not “robust” when evaluated with the Fragility Index (FI). A secondary analysis of data from a previous study was performed to investigate (1) the correctness of the findings, (2) the association between FI, p-value and post hoc power, (3) median power to detect a medium effect size, and (4) the implementation of sample size analysis in these randomized controlled trials (RCTs).

Methods

In addition to the 48 studies listed in the appendix accompanying the original study by Khan et al. (2017) we did a follow-up literature search and 18 additional studies were found. In total 66 studies were included in the analysis. We calculated post hoc power, p-values and confidence intervals associated with the main outcome variable. Use of a priori power analysis was recorded. The median power to detect small (h > 0.2), medium (h > 0.5), or large effect (h > 0.8) with a baseline proportion of events of 10% and 30% in each study included was calculated. Three simulation data sets were used to validate our findings.

Results

Inconsistencies were found in eight studies. A priori power analysis was missing in one-fourth of studies (16/66). The median power to detect a medium effect size with a baseline proportion of events of 10% and 30% was 42% and 43%, respectively. The FI was inherently associated with the achieved p-value and post hoc power.

Discussion

A relatively high proportion of studies had inconsistencies. The FI is a surrogate measure for p-value and post hoc power. Based on these studies, the median power in this field of research is suboptimal. There is an urgent need to investigate how well research claims in orthopedics hold in a replicated setting and the validity of research findings.
Estimates Model of Factors Affecting Financial Distress: Evidence from Indonesian State-owned Enterprises
Authors: Assagaf Aminullah , Murwaningsari Etty , Gunawan Juniati , Mayangsari Sekar
Published: May 2019

This study as a model estimation of factors that influence the financial distress of State-Owned Enterprises. This study contributes to the gap in an earlier study using a logistic model which classifies companies with indicators one for companies experiencing financial distress and a zero for the company is not experiencing financial distress, so it is not possible to do research specifically on one group of firms, for example, companies that experience financial distress. This study uses a marginal approach in measuring financial distress that is proxy with a marginal score with a more realistic and proven mathematics and accounting calculations. For the company's management with state, companies can use these results as a reference in evaluating the achievements of past operating performance, or to formulate strategies and policies in the future of corporate planning in order to achieve the level of marginally better scores or financial distress. This study needs to be continued by using secondary data corresponding realization of audited financial statements, so the result is more realistic and relevant because it uses the data of financial statements that meet the accounting standards.
The Effect of Different Energy Source on the Growth Performance of Clarias gariepinus Fingerlings
Authors: Opeh P. B. , Eteng S. U.
Published: May 2019

This study was aimed to evaluate and compare the effects of different selected energy feed stuff namely; Maize (DT1), Guinea corn (DT2), millet (DT3), and wheat (DT4) on the growth performance and body composition of African sharptooth catfish (Clarias gariepinus Burchell) fingerlings. This energy feedstuff in addition with other feed ingredients was used to formulate four (4) isonitrogenous and isoenergy diets at 40% crude protein. The energy feedstuffs were formulated at 36.31%, 38.26%, 37.09% and 40.05% level of inclusion respectively. The experiment in the ponds used a set of 2 hapas with mesh size 2 mm in each pond measuring 1.62 m2, therefore replicating the experiment 2 times in a completely randomized design The evaluation of the physical parameters revealed that there was no significant difference (p>0.05) in moisture, ash, lipid, fibre, protein and nitrogen free extract among the treatment (diets). The diet with maize (DT1) has the highest growth rate followed by diet containing millet (DT3), guinea corn (DT2) and diet containing wheat (DT4) had the lowest growth rate. This study, revealed that, among the energy feedstuffs evaluated maize (DT1) produced better growth parameters and could be recommended for on-farm aqua-feed.
STUDI KOMPARASI LIFE CYCLE COST PADA GEDUNG APARTEMEN
Authors: Iskandar Alexander , Alifen Ratna , Budiman Januar
Published: May 2019

Dalam mendesain suatu gedung apartemen yang ekonomis dan efisien, analisis life cycle cost dibutuhkan untuk mendapatkan desain yang paling efisien selama umur pakai bangunan. Berdasarkan penelitian sebelumnya, telah didapatkan bahwa biaya energi merupakan komponen biaya terbesar dalam life cycle cost suatu gedung.

Data pada penelitian ini berasal dari manajemen pengelola gedung dan beberapa supplier produk dan peralatan yang di teliti. Analisis penelitian ini dilakukan dengan menjumlahkan biaya awal (C), biaya perawatan (M), biaya operasional (O), biaya penggantian (R) dari tiap produk dan peralatan. Sebelum dijumlahkan semua biaya dikonversikan dengan metode annual cost.

Penelitian ini menunjukan bahwa penggunaan metode LCC pada saat menentukan peralatan mekanikal dan elektrikal yang digunakan pada suatu gedung apartemen dapat menghasilkan penghematan pada biaya pengelolaan gedung. Selain itu penelitian ini menunjukan bahawa sumber pendanaan awal yang berasal dari pinjaman bank tidak memberikan pengaruh terhadap pengambilan keputusan untuk pemilihan suatu produk dan peralatan yang berkaitan dengan energi

 

In designing an apartment building that is economical and efficient, life cycle cost analysis is needed to obtain the most efficient design for service life of the building. Based on previous studies, it has been found that the energy cost is the largest cost component in the life cycle cost of a building.

The data in this study came from the building management and from multiple suppliers of products and equipment. The analysis is done by summing the initial cost (C), the cost of maintenance (M), operating costs (O), the cost of replacement (R) of each product and equipment. Before all of the costs being added, these costs converted to annual cost method.

This study shows that the use of the LCC method when determining the mechanical and electrical equipment used in an apartment building can result in savings on the building operational cost. In addition, these studies show that the source of initial funding from bank loans does not give effect to the decision making for the selection of a product and equipment related to energy.
Positive Psychology and Coping
Authors: Dewe Philip
Published: May 2019

The positive psychology movement offers a new dimension to coping research. It is possible to identify a number of trends in coping research that have, one way or another, suggested a route through which the positive can be emphasized, offering what must be a better understanding of the nature of coping. These trends include focusing more on both positive and negative emotions so as to capture what best expresses the work experience; a greater emphasis on the appraisal process and the role of positive meanings, emphasizing the importance of positive emotions and the role they play as a coping resource; and developing a better understanding of proactive coping and what is meant by coping effectiveness.
Character and Wellbeing
Authors: Wright Thomas A. , Lauer Tyler
Published: May 2019

The possible relationship between character and wellbeing has long fascinated both scholars and laypeople alike. Despite this widespread interest, the manner in which we consider both wellbeing and character is subject to much debate and warrants further attention. To that end, three primary contributions are set forth in this chapter. First, a brief overview of the organizational research on wellbeing is provided. Second, a working definition of character is introduced. Finally, exciting future directions for applied researchers interested in the relationship between character and wellbeing are presented.
Prevention advocates toil to maintain influence in a field in crisis mode
Authors: Enos Gary
Published: May 2019

Greater public and policymaker attention to substance use–related issues hasn't exactly made the case for increased investment in prevention an easier sell. If anything, a strong argument can be made that today's predominantly narrow focus on the opioid overdose crisis has so tilted the balance in favor of crisis intervention that less attention than before is being paid to the mission of preventing problematic substance use before it begins.
Plasmon Based Double‐Layer Hydrogel Device for a Highly Efficient Solar Vapor Generation
Authors: Sun Zeyu , Wang Jiajun , Wu Qinglei , Wang Zongyuan , Wang Zhao , Sun Jie , Liu Chang‐Jun
Published: May 2019

Solar vapor generation is a facile and an efficient way for solar energy harvesting, which is applied to address the issue of fresh water extraction from sewage or brine. Several solar vapor generation devices have been developed in the past few years, but the low evaporation rate still remains as a challenge. In this work, a novel double‐layer solar vapor generation device, named as Ag‐PSS‐AG/AG device, is reported. This device is based on the hierarchical composition of silver nanoparticles (Ag NPs) and poly (sodium‐p‐styrenesulfonate) (PSS) decorated agarose gel (AG). The device reveals a synergetic effect of the two layers with high light‐harvesting and water‐transfer performance, respectively, leading to an ultrahigh vapor generation rate of 2.10 kg m−2 h−1 with a solar thermal efficiency of 92.8% under 1 sun illumination. This high evaporation rate is mainly owing to the powerful light‐thermal conversion of Ag NPs as well as the outstanding water transfer capability of agarose hydrogel. Consequently, this device can be directly used for the purification of sewage and muddy water. It is also promising for applications in separation, humidity management, and others.
Embedding RhPx in N, P Co‐Doped Carbon Nanoshells Through Synergetic Phosphorization and Pyrolysis for Efficient Hydrogen Evolution
Authors: Chi Jing‐Qi , Zeng Xiao‐Jun , Shang Xiao , Dong Bin , Chai Yong‐Ming , Liu Chen‐Guang , Marin Melinda , Yin Yadong
Published: May 2019

Rational design and controllable synthesis of well‐defined nanostructures with high stability and Pt‐like activity for hydrogen evolution reaction (HER) are critical for renewable energy conversion. Herein, a unique pyrolysis strategy is demonstrated for the synthesis of RhPx nanoparticles (NPs) in N, P co‐doped thin carbon nanoshells (RhPx@NPC nanoshells) that display high electrocatalytic activity and stability over a wide pH range. This strategy involves simultaneous phosphorization and pyrolysis processes that can produce highly‐dispersed RhPx NPs within N, P co‐doped carbon nanoshells and at the same time induce thinning of carbon nanoshells from inside out. The resulting RhPx@NPC nanoshells not only possess Pt‐like activity for HER with low overpotentials to achieve 10 mA cm−2 (22 mV in 0.5 m H2SO4, 69 mV in 1.0 m KOH, and 38 mV in 1.0 m phosphate buffered saline (PBS)) but also provide long‐term durability in a wide pH range. The remarkable HER performance of RhPx@NPC nanoshells is ascribed to the high surface area, abundant mesoporosity, strong catalyst–support interaction, ultrathin carbon encapsulation, and N, P co‐doping. This work provides an effective strategy for designing heterostructured electrocatalysts with high catalytic activity and stability desired for reactions that may occur under harsh conditions.
UV‐Triggered Polydopamine Secondary Modification: Fast Deposition and Removal of Metal Nanoparticles
Authors: Zeng Yi , Du Xin , Hou Wei , Liu Xiaojiang , Zhu Cun , Gao Bingbing , Sun Liangdong , Li Qiwei , Liao Junlong , Levkin Pavel A. , Gu Zhongze
Published: May 2019

Since the first report in 2007, polydopamine (PDA) coating has shown great potential as a general and versatile method to create functional nanocoatings on arbitrary substrates. Slow kinetics and poor controllability of the coating and secondary modification processes, however, have limited the further development of this attractive method. In this work, it is demonstrated that UV irradiation at 365 nm significantly accelerates the process of secondary modification of a PDA‐coated surface. The kinetics of both thiol and amine modifications of PDA are increased 12‐fold via UV irradiation, while the kinetics of metal ion reduction at the PDA interface is increased more than 550 times. Moreover, it is demonstrated that irradiating a PDA/metal nanoparticle composite surface with UV light at 254 nm leads to dissolution of the deposited metal nanoparticles (MNPs). Finally, grayscale metallic patterns, dynamic deposition, and removal of MNPs on PDA surface are realized with the proposed method.
Small‐Molecule‐Doped Organic Crystals with Long‐Persistent Luminescence
Authors: Han Jiangli , Feng Wenhui , Muleta Desissa Yadeta , Bridgmohan Chelsea Nicole , Dang Yangyang , Xie Guohua , Zhang Haoli , Zhou Xueqin , Li Wei , Wang Lichang , Liu Dongzhi , Dang Yanfeng , Wang Tianyang , Hu Wenping
Published: May 2019

Traditional long‐persistent luminescence (LPL) materials, which are based on inorganic systems containing rare elements and with preparation temperatures of at least 1000 °C, exhibit afterglow times of more than 10 h and can be tuned for different applications. However, the development of this field is hindered due to the large thermal energy consumption and the need for nonrenewable resources. Thus, the development of a “green” design and preparation of LPL materials is of some importance. A doped‐crystalline material based on two metal‐free organic small molecules is easily prepared through ultrasonic crystallization at room temperature. It has a high‐quality, single‐crystalline structure, and visible LPL performance with a duration of more than 6 s upon low‐energy photoexcitation. A green, flexible, and convenient screen‐printing technology for controllable pattern anticounterfeiting is then developed from this purely organic material, which improves the prospects for commercial utilization in the future.