bluuebunny/crossref_metadata_2025 huggingface dataset:
Where is all the gold?
Authors: Handley M.
Published: June 2023

The Witwatersrand Basin contains by far the most gold ever found, and has hosted mining from its discovery in 1886 to the present. For many years, South Africa was the world's largest producer of gold, nearly all of which came from the Witwatersrand. Since 2000, South Africa has fallen back several positions because of declining gold output. There are many complex and varied reasons for this; however, declining gold resources in the Witwatersrand Basin are not one of them. As far as the author knows, there are no qualified estimates in the literature of gold remaining in the Witwatersrand Basin. This paper collects mining data from several sources and then, using elementary gold accounting and error analysis, attempts to estimate the amount of gold remaining in the Witwatersrand Basin. It includes gold underground in existing and defunct mines, in evaluated ore resources, and dumps. Compiled data from 1887 to 2019 shows that 50 200 t of gold were produced by Witwatersrand mines, while it is estimated that a further 48 100 t remain underground, both within and outside of mine leases, a further 1 600 t on the surface in tailings, and an unknown amount in rock dumps. Nearly all of this gold will remain inaccessible with current mining methods, and major technical developments in mining will be necessary before any of the gold can be categorized as a code-compliant resource or reserve. To win this prize, the mining industry will have to rethink its approach to mining, both in old mining leases and in the unexploited ground. It will also have to find effective means of preventing gold theft and informal mining, which are on the rise.
A Importância do Design de Comunicação no Processo de Disseminação de Práticas Comunitárias em Bairros Sociais: O Balteiro
Authors: Martins Nuno , Brandão Daniel , Guimarães Leonor , Penedos-Santiago Eliana , Brandão Emílio
Published: June 2023

No presente artigo pretende-se demonstrar de que modo a investigação em design de comunicação pode contribuir para a disseminação de práticas comunitárias em contextos economicamente desfavorecidos, como é o caso dos bairros sociais. Este estudo surge no âmbito do projeto de investigação ECHO, onde a principal missão é conhecer e documentar duas práticas comunitárias auto-iniciadas no bairro social do Balteiro, em Vila Nova de Gaia, Portugal, com o objetivo de as divulgar e estimular a sua replicação em contextos sociais análogos. Começa-se por apresentar uma revisão de literatura sobre o papel do design ao serviço das comunidades, focada, em particular, nos conceitos de design social e do design universal, que fundamenta a relevância e pertinência da problemática estudada. De seguida, descreve-se o caso de estudo do Balteiro. Apresentam-se as metodologias adotadas nesta investigação, nomeadamente, o conjunto de entrevistas realizadas com o objetivo de conhecer a história das duas práticas comunitárias, e que serviram de base ao desenvolvimento de um estudo prévio para uma plataforma online e um conjunto de documentários. Este estudo comprovou a importância do envolvimento dos designers neste processo de disseminação, em equipas que deverão ser multidisciplinares. O trabalho de investigação no terreno deve ser próximo da comunidade, das instituições e dos diferentes atores sociais envolvidos, de forma a compreender a complexidade do contexto de estudo e definir o modo de atuação do design. A experiência empírica adquirida com este estudo demonstrou que o trabalho na área social deve ser desenvolvido a nível local, focado em pequenas comunidades ou organizações informais, com a consciência de que os resultados se atingem de forma lenta e gradual.
Intervenções de urbanismo sensível a água para ampliação da infiltração em área de recarga de aquíferos: Estudo na Cidade do Paranoá - DF
Authors: Santana Jane Cristina do Carmo , Bezerra Maria do Carmo Lima , Oliveira Aline Nóbrega
Published: June 2023

Afim de promover intervenções em áreas urbanas consolidadas visando ampliar a infiltração, o presente trabalho aborda os serviços ecossistêmicos hídricos e as técnicas de urbanismo sensível à água. O estudo se dá na Região Administrativa (RA) do Paranoá no Distrito Federal, assentada em área de recarga de aquífero. A análise se baseia na pesquisa de Oliveira (2022), que identificou a necessidade de alteração dos padrões urbanos nas RA visando provisão hídrica. Esses foram ajustados com mapeamentos referentes a apropriação de usos dada pela população. Como resultado foram identificadas 36 praças que contam com 39.489,75m² de superfícies impermeável; 3.548,84m² de compactadas/solo exposto e 27.928,44m² de cobertura vegetal. Para intervenção se selecionou 3 praças, onde se propôs: ampliação de áreas gramadas, plantas com folhagem, elementos de acumulação e medidas de conservação da água no solo. Como resultado se obteve aumento de 1.820,32m² para melhoria dos processos de infiltração e, ainda, melhoria no microclima e o conforto térmico local. Das 3 intervenções nas praças do Paranoá, se verificou que a proposta para a praça central se destina somente a ela, devido a sua particularidade, enquanto as outra duas podem ser replicadas nas demais 33 praças, com adaptações, respeitando o dimensionamento específico de cada uma. As intervenções visaram manter a multifuncionalidade, garantindo as diferentes funções esperadas pela comunidade como lazer e interação social associadas a função ecológica hídrica.

PALAVRAS-CHAVE: Áreas Verdes Urbanas. Urbanismo Sensível a Água. Recarga de Aquíferos.
Brimblecombe, K.R. et al. (2023) Inhibition of striatal dopamine release by the L-type calcium channel inhibitor isradipine, co-varies with risk factors for Parkinson’s. v1
Authors: Brimblecombe Katherine , J Cragg Stephanie
Published: June 2023

This collection contains three protocols detailing methods used in Brimblecombe, K.R. et al. (2023) Inhibition of striatal dopamine release by the L-type calcium channel inhibitor isradipine, co-varies with risk factors for Parkinson’s.
Stereotactic Viral Injection into Subthalamic Nucleus in Mice v1
Authors: P. Elizabeth
Published: June 2023

This is a protocol describing the surgical procedure of injecting AAV viruses into the subthalamic nucleus of a mouse. It contains information regarding the stereotactic setup, surgery preparation, anesthesia, craniotomy, injection, and recovery. This protocol has been adapted from Maite Azcorra's protocol for midbrain viral injections.
Isolation and Processing of Embryonic and Postnatal Brains v1
Authors: not provided maryana.nissan
Published: June 2023

This protocol describes: -Harvesting embryos from females from embryonic day 10 [e10] to embryonic day 18 [e18] -Brain isolation of embryonic (e10-e18) and postnatal brains (p0-p30) -Processing and Freezing of embryonic and postnatal brains
Rotarod Test to assess motor coordination in a mouse parkinsonian model v1
Authors: not provided natalia.lopezgonzalezdelrey
Published: June 2023

Protocol for the evaluation of motor coordination in the rotarod assay in parkinsonian mice.
Open Field test to assess spontaneous locomotion behavior in parkinsonian mice v1
Authors: not provided natalia.lopezgonzalezdelrey
Published: June 2023

The Open Field task is a simple sensorimotor test used to determine general activity levels, gross locomotor activity, and exploration habits in rodent models of CNS disorders.
Transcardiac Perfusion of Mouse for Brain Tissue v1
Authors: not provided maryana.nissan
Published: June 2023

Transcardiac perfusion is a method used for clearing blood and preserving the mouse brain for immunostaining.
First Record and Distribution Extension of Two Emperor Fishes, Lethrinus semicinctus and Lethrinus olivaceus to the East Coast of Peninsular Malaysia
Authors: Mat Piah Siti Asmal , Lee Hui Hui , Abd Latiff Nur Athirah , Wong Li Lian , Okamoto Jo , Motomura Hiroyuki , Kimura Seishi , Seah Ying Giat
Published: June 2023

This study reports the occurrence of two species of Lethrinus (family Lethrinidae) on the east coast of Peninsular Malaysia. The specimens were caught by commercial bottom trawlers operating in the southern part of the South China Sea and landed at several fish landing ports. Lethrinus semicinctusValenciennes, 1830 and Lethrinus olivaceus Valenciennes, 1830, previously known from Borneo, with the latter also occurring in the Straits of Malacca on the west coast of Peninsular Malaysia, are now documented as new records of geographic range in the northeastern coast of Peninsular Malaysia. These records add to published Malaysian literature with photographic records, locality details, collection numbers and preserved specimens. Diagnostic characters for both species are given, as well as detailed morphometric and meristic data.
Production, Organoleptic, and Biological Activities of Belacan (Shrimp Paste) and Pekasam (Fermented Freshwater Fish), the Ethnic Food from the Malay Archipelago
Authors: Khudair Abedelazeez J.D. , Mohd Zaini Nurul Solehah , Jaafar Ahmad Haniff , Meor Hussin Anis Shobirin , Wan-Mohtar Wan Abd Al Qadr Imad , Abd Rahim Muhamad Hafiz
Published: June 2023

Various popular fermented foods are produced commercially or at the household level. Chemical, physical, and microbiological changes may occur, either desirable or undesirable, in the food matrix during fermentation. Due to the scarcity of information in the literature regarding belacan (fermented shrimp) and pekasam (fermented freshwater fish) originating from the Malay Archipelago, this review will focus on the physiochemical changes, nutritional, microbiological, sensory, and biological activities of these food ingredients. Belacan is primarily composed of fermented blocks of shrimp with salt and usually is added as condiments in a small amount in cooking. In contrast, Pekasam consisted of freshwater fish in its original form, often fermented with ground toasted rice and natural acidulants, and can be used as the main dish. Both belacan and pekasam contain appreciable quantities of umami amino acids and 5′-ribonucleotides such as glutamate, inosinate, and guanylate from the protein degradation by both endogenous proteases and microbial growth. Unfortunately, the breakdown of proteins can contribute to the rise of biogenic amines, which can cause adverse effects on sensitive individuals. The growth of lactic acid bacteria is common, which is often considered safe, but spoilage microorganisms can easily contaminate the product in an unfavourable environment. Therefore, with rich nutrients and biological activities, the appropriate consumption of these food ingredients may contribute to better consumer health while increasing the acceptability of Malay traditional cuisines.
Mapping Sea Grass Coverage of Tanjung Benoa Bali Using Medium Resolution Satellite Imagery Sentinel 2B
Authors: Zainul Hidayah , De Oliveira Vieira Lucas , Rahma Safitri , Herlambung Aulia Rachman , Abdur Rahman As-Syakur Abdur Rahman As-Syakur
Published: June 2023

Seagrass beds are important components of a coastal ecosystem. This ecosystem serves as the primer producers of the water food chain, habitat for marine biota, produces organic carbon, and indirectly contributes to the economic well-being of coastal communities. However, the ecosystem is vulnerable to damage caused by natural factors and human activities. The objectives of this study were, firstly to identify the distribution of seagrass beds in Tanjung Benoa using Sentinel 2B satellite imagery and secondly to compare classification results from two different approaches namely pixel-based image classification and object-based image classification. Accuracy-test was carried out using field data reference of 195 sample points in the form of a 10 m X 10 m transect. The image pre-processing process was conducted with Bottom of Atmosphere (BoA) correction using the Dark Object Subtraction (DOS) method. Furthermore, the water column correction was performed using the Depth Invariant Index (DII) and the Lyzenga algorithm. The mapping results showed that the area of seagrass beds in the shallow waters of Tanjung Benoa reaches 242.99 ha. There were seven seagrass species in the study area, with an average cover of 75%. The accuracy of object-based image classification was higher than that of pixel-based classification with a difference up to 25% for six classes classification and 15% for two classes classification. Excellent results for classifying seagrasses based on cover density can be obtained when high-resolution satellite imagery and OBIA are combined with the SVM or Fuzzy Logic algorithm.
Evaluation of nerve‑sparing radical hysterectomy introduction efficiency in the regional cancer center
Authors: Kolotilov Yu. A. , Kruglov E. A. , Kazantsev A. N. , Unguryan V. M.
Published: June 2023

The purpose of the study. To evaluate the immediate and long–term results of the introduction of nerve‑s paring radical hysterectomy into the practice of the center, namely, the frequency of complications, duration of surgery, blood loss, genitourinary disorders and compare the data obtained with the data of the world literature on this issue.

Patients and methods. In the period from August 2019 to October 2022, 55 patients diagnosed with cervical carcinoma who underwent nerve‑ sparing radical hysterectomy type III/C1 were treated in the conditions of the regional clinical oncological dispensary. The age category ranged from 31 to 69 years, the average age was 47.3 years. The following postoperative indicators were analyzed: duration of surgery, blood loss, amount of residual urine, duration of hospital stay after surgery, complications, mortality, number of lymph nodes examined. The analysis of long‑term oncological results in patients with a follow‑up period of more than 12 months (42–12 months) was carried out, the frequency of relapses, the frequency of progression, and mortality from progression were estimated.

Results. The obtained postoperative averages, such as: the duration of the operation, amounted to 286 minutes; blood loss – 216.1 ml, the volume of residual urine on the 5th day 52.4 ml, the duration of hospital stay after surgery 11.1 days, complications of the II degree according to Clavien–Dindo – 3.6 %, complications of the III degree according to Clavien‑ Dindo – 3.6 %, there was no postoperative mortality, the number of lymph nodes examined was 18.3. During the follow‑up period, the recurrence rate was 0 %, relapse‑free survival was 91 %, progression and mortality from progression were 7 % and 3.5 (4 and 2 patients), respectively. The effectiveness of the implementation of the methodology was evaluated by comparing it with the data given in the world literature on a similar issue. At the same time, it was found that the duration of the operation, blood loss, the frequency of complications and genitourinary disorders, the frequency of relapse and progression did not differ significantly from the data of the international literature.

Conclusion. The introduction of the technology of nerve‑ sparing hysterectomy of the uterus type III/C1, in cervical cancer surgery is relatively safe and approachable in a regional oncology hospital.
THE WAR TIME ART ARCHIVE
Authors:   «Museum of Contemporary Art» NGO, Balashova Olga , Hleba Halyna ,   «The War time Art Archive», Lysun Tetiana ,   «The War time Art Archive», Klochko Valeriia ,   Taras Shevchenko national University of Kyiv, Levchenko Illia ,   Taras Shevchenko national University of Kyiv
Published: June 2023

With the beginning of the full-scale invasion of Russia (February 24, 2022), the NGO «Museum of Modern Art» started the project «The Wartime Art Archive». As part of the project, co-curators collect artists' works from open sources. The researchers observe the artists and record their reactions to the war. This initiative aims to create an archive of martial art for its preservation and further research. In an interview with the co-curators of the archive, Olga Balashova, Tetiana Lysun, and Halyna Hleba, we talked about the history of the creation of the archive, its prospects, retraumatization, documenting events through an artistic image and art during the war.
Oriental plots in the history of the Saints Peter & Paul Garrison church (Jesuit church) in Lviv.
Authors:   Centre of military chaplaincy LA UGCC (Lviv, Ukraine), Druzdiev Oleh
Published: June 2023

The opening of the former Jesuit Cathedral of the Saint Apostles Peter and Paul in Lviv in December 2011, which got the status of the Garrison Church, actualized the issue of this research and the understanding of its historical and cultural heritage. The process of church restoration that started in 2012 and continues to this day has become the catalyst for these studies. To a large extent, significant attention to artistic and historical research on the exterior and interior of the temple has been drawn by the need for a professional restoration of the church’s ornaments. Taking into account the fact that the majority of the church’s ornaments were created mostly in the XVII-XVIII centuries, its research provides an opportunity to understand the artistic and religious culture of the region at that time in a better way. At the same time, such studies provide an opportunity to research interregional cultural interactions as well. One of the examples is the plots connected with the events and peoples that inhabited the Near and Far East. Eastern motives occupy a special place in the activity of the Society of Jesus, which was particularly successful in spreading the Word of God in the Orient starting from the XVII-XVIII centuries. According to the sources, Lviv has also played an important role in the «Eastern»” plans of the Jesuits. In a way, Lviv was a center from which Jesuits gradually expanded their structure to the East. In particular, some monks started their missions to the Ottoman Empire and neighboring lands from Lviv. Moreover, a significant number of different nations of the East among whom monks carried out their missionary work was located in the city. These events were reflected in the artistic ornaments of the church of the Saint Apostles Peter and Paul as well as in its activity. In spite of the fact that the Eastern motives could be studied as a separate research group, they comprised a logical part of the general church ornaments that were based on the idea of missionary work. Taking into account what was mentioned before, this article is an attempt to interpret the ornaments of the Garrison Church of Saint Apostles Peter and Paul (former Jesuit Cathedral) a significant part of which is dedicated to Eastern motives.
Graphic heritage of R. Lisovsky in Lviv publications of the 1920s
Authors:   Lviv Polytechnic National University (Ukraine), Melnyk Oksana , Shtets Viktor ,   Lviv Polytechnic National University (Ukraine)
Published: June 2023

The article reveals the peculiarities of Robert Lisovsky's graphic works, made for Lviv publishing houses in the 1920s. The importance of the communication environment for the artist as a factor in his creative growth is proven. Daily artistic dialogue with experienced and young artists, activities in circles, participation in exhibitions and being in demand in the publishing field show the artist as an important part of the Lviv artistic community. R. Lisovskyi worked on covers, decorative and ornamental passports for books, screensavers for periodicals, publishing stamps and emblems. He fundamentally changed the approach to the design of printed publications. He also formed and popularized a new polygraphic aesthetic among Lviv publishers and readers. A characteristic feature of these works is the presence of an expressive decorative or pictorial design. The sources of inspiration were the heritage of Ukrainian national art, interpreted according to the aesthetic and technological requirements of the time. Also, R. Lisovsky gently integrates new artistic ideas into his projects. This is evidenced by the significant rate of innovation in Lviv works. The main features of Lviv works are the synthesis of tradition and innovation, revealed in decorative motifs and plastic language. Integrity is inherent in the formal compositional solution of decorative, symbolic and informational elements of covers and applied works. The individual handwriting of the artist is characterized by the special ratio of black to white and high graphic culture. Traditional baroque or folk motifs remain a priority for the artist, but they have a more expressive and constructive formal-plastic design. It has been proven that the aesthetic function of R. Lisovsky's applied works is as expressive as it is utilitarian.
Everyone has their own history of exhaustion
Authors:   Taras Shevchenko national University of Kyiv, Khibovskyi Vladyslav
Published: June 2023

After every crisis, there is a period of revival and energy recovery. After every peak of development goes decaying and gradual fading of resources. This circulation is inherent to every individual life, political entity, global ecosystem or any other natural or man-made processes. Fountain of Exhaustion by Pavlo Makov suggests to take a look at a segment of this circulation – a present period of all-around exhaustion without any visible improvement or solution in sight. Pavlo Makov. Fountain of Exhaustion. Acqua Alta is a contextually and chronologically broad narrative about the development of the work of Pavlo Makov, presented at the Ukrainian Pavilion at Venice Biennale 2022. This book is an addition to the pavilion, an individual work that provides wider context for the perception, resonance and interpretations of the Fountain of Exhaustion. The account is divided into 16 chapters that introduce the reader to the exhibitions, projects and other Makov’s artistic practices that are directly connected to the story of the Fountain. The second part of the book consists of short reflections of artists, curators and writers on phenomena related to the story or contexts of the work: exhaustion, water, perception of the past and the present, intimate landscapes etc. Besides the narrative of the development itself, Borys Filonenko, as the author of the main textual section, in the first place tried to reveal the Fountain’s rising above primary Kharkiv context into a wider dimension of global concerns. Since, as it seems to me, the book contains deeper connections between the chapters and texts at the end, after presenting the structure, I give my reflections about the key parts of the conceptual side of Makov’s artwork, which can be followed throughout the whole book: instability of the form and stability of the idea, the phenomenon of exhaustion, social rejection and local myth, the meaning of water. Moreover, I comment on the presented account of Makov’s joint projects with other artists. The relevance of this artwork is conditioned by the massive destabilization in many spheres of social and individual lives: world politics, ecology, socially traumatic events. This book sums up the observation on what happens with the un-exhaustible idea and the long-denied exhaustion.
INFLUENCE OF FAN IDENTIFICATION AND PERCEIVED GROUP NORMS ON FANS' PURCHASING INTENTIONS TOWARDS CURRENT AND FORMER FOOTBALL CLUB SPONSOR
Authors:   University of Split, Faculty of Economics, Business and Tourism, Pepur Mario , Dedić Goran , Rogulj Duje
Published: June 2023

Sports, due to its publicity and social role is an exceptional channel for sponsorship activities. In addition to marketing of sports, goal of sports marketing is marketing through sports. This paper explores changes in fans’ buying intentions toward current and former sponsors when a change of a football club’s main sponsor occurs. Additionally, the role of fan identification and perceived group norms on purchasing intentions is explored. The research was conducted on a sample of 370 respondents. The results of hierarchical regression analysis show that fan identification and perceived group norms are significant predictors of purchasing intentions. Higher values of the Fan Identification and the Perceived Group Norms (PGN) indexes are related to the more pronounced intention to buy more often with the current and less often with the former sponsor. The research confirms the mediating role of PGN in relation to the HFI index and purchase intentions. This work contributes to knowledge by providing insights into the dynamics of fans’ purchase intentions in the specific situation of sponsor change.
ANALYSIS OF THE ENTREPRENEURIAL ORIENTATION OF GENERATIONS Z AND Y
Authors:   Sveučilište Vern' Zagreb, Bekić Ivana , Ivanković Jadranka , Bednjanec Andrea
Published: June 2023

Poduzetnički način razmišljanja može se opisati kao sposobnost uočavanja poduzetničkih prilika, sklonost proaktivnom i inovativnom djelovanju te spremnost za preuzimanje rizika. Poduzetnički način razmišljanja i djelovanja jedan je od ključnih pokretača svake privrede. Rad se bavi analizom poduzetničke orijentacije pripadnika Y i Z generacije koji će u skorije vrijeme činiti većinu radno i poduzetnički aktivne populacije. U radu se prikazuju rezultati provedenog istraživanja odrednica poduzetničke orijentacije na uzorku od 216 studenata Y generacije i 322 studenta Z generacije. Polazne pretpostavke istraživanja, postavljene na temelju prethodnog pregleda literature, bile su da se pripadnici Y i Z generacije međusobno razlikuju prema odrednicama poduzetničke orijentacije (inovativnosti, proaktivnosti i preuzimanja rizika) te da su pripadnici Z generacije proaktivniji, inovativniji i skloniji preuzimanju rizika u odnosu na pripadnike Y generacije. Na temelju rezultata provedenog istraživanja potvrđena je statistički značajna razlika u dimenzijama poduzetničke orijentacije između pripadnika različitih generacija, ali u korist pripadnika Y generacije.
PRICE JUMPS IDENTIFICATION USING INTEGRATED VARIANCE ESTIMATORS
Authors:   Sveučilište u Zagrebu, Ekonomski fakultet, Arnerić Josip , Stürmer Marcela
Published: June 2023

Tehnološki napredak i sve veća dostupnost visokofrekventnih podataka, opaženih u jako kratkim vremenskim intervalima, primjerice, svake minute ili sekunde, omogućili su upotrebu potpunijih informacija za neparametarsku procjenu kontinuiranog stohastičkog procesa cijena. Pri tome se sastavnica skoka najčešće opisuje Poissonovim stohastičkim procesom, koja se kao aditivni član pridružuje komponentama Itôva procesa s vremenski promjenjivim parametrima. Pridruživanje skokova stohastičkom procesu cijena bitno mijenja tradicionalno shvaćanje modela vrednovanja financijske imovine te ima ozbiljne posljedice za upravljanje financijskim rizikom. Stoga su ciljevi ovoga rada teorijski obrazložiti uzroke i posljedice cjenovnih skokova, empirijski identificirati cjenovne skokove te utvrditi njihov doprinos ukupnoj varijanci prinosa na hrvatskom dioničkom tržištu. Budući da je realizirana varijanca zapravo procjena integrirane varijance (stohastičkog integrala), razvijeni su statistički testovi kojima se uspoređuju realizirana varijanca prinosa koja je robusna i ona koja nije robusna na cjenovne skokove. U tom kontekstu Barndorff-Nielsen i Shephardov test pokazuje da je u promatranom razdoblju intenzitet skokova 76,19%, a njihov doprinos ukupnoj varijanci prinosa CROBEX-a varira između 7,36% i 83,73%. Rezultati potvrđuju i da su cjenovni skokovi više izazvani općepoznatim šokovima nego neslaganjima među investitorima.
Safety and Efficacy of Suprachorodial Injection of Triamcinolone Acetonide: Review of a Novel Treatment
Authors: Jourieh Mohammad ,   Research Institute of Eye Diseases, Moscow, Russia
Published: June 2023

Suprachoroidal injection is a unique, minimally invasive procedure for drug delivery to the posterior segment of the eye. Drugs can be delivered easily via microneedles that are slightly longer than the scleral and conjunctival thickness at pars plana. Suprachoroidal delivery of corticosteroids allows higher steroid concentration in the posterior segment tissues with minimal drug concentration in the anterior segment, which decreases the risk of other adverse ocular events like steroid-induced elevation of intraocular pressure and cataract progression. Several clinical trials have evaluated the safety and efficacy of suprachoroidal injection of triamcinolone acetonide in various ocular conditions. This article reviews the novel treatment as a promising route for drug delivery.
Reproxalap for the Treatment of Dry Eye Disease
Authors: Swartz Tracy Schroeder ,   Southeast Eye Services, Huntsville, AL, USA, Powell Whitney ,   Southeast Eye Services, Huntsville, AL, USA
Published: June 2023

Reproxalap is a reactive aldehyde species inhibitor. This article investigates reproxalap’s ability to control ocular inflammation in non-infectious uveitis, allergic conjunctivitis and dry eye disease. Clinical trials for reproxalap were reviewed for efficacy and tolerability. Reproxalap appears to be an effective treatment for dry eye disease, with satisfactory tolerability.
Bases del conocimiento molecular del autismo con variantes VARS y NRXN1: a propósito de un caso
Authors: Echeverri Chica Daniela , Moreno Giraldo Lina Jhoanna
Published: June 2023

Background: Autism spectrum disorder (ASD) comprises heterogeneous alterations that compromise neurodevelopment, mainly the ability to communicate and relate to the environment, and do not resolve at any time in life. It presents with multiple profiles and its clinical expression depends on different factors where genetics and environmental factors play a fundamental role. This is an important group of delayed psychomotor development in the pediatric population and despite not having a curative treatment, early identification will allow an early initiation of neurobehavioral therapies, targeted complementary management and appropriate clinical follow-up, improving the prognosis and offering a Specific genetic counseling, carrying out primary prevention strategies, which will impact the burden of disease. Identifying it early makes it easier to find different genetic associations through tests such as next generation sequencing (NGS), constituting a path to develop future therapies.
Case presentation: The case of a 5-year-old male patient with delayed psychomotor development due to impaired language is described, in whom three variants of the NRXN1 and VARS2 genes associated with ASD were detected through an NGS test, allowing genetic counseling. adequately and guiding the therapy individually.
Results: Using a next-generation sequencing test, three variants of the NRXN1 and VARS2 genes associated with autism spectrum disorder were detected, allowing appropriate genetic counseling, and guiding individualized therapy.
Accidente cerebrovascular isquémico y terapia de entonación melódica: a propósito de un caso
Authors: Palacios Lenis Jennifer , Moncaleano Obregón Paula Andrea , Córdoba Hoyos Vanessa , Larrahondo Gómez María , Guzmán Sánchez Pilar Andrea
Published: June 2023

Introduction: Brain alterations in adults bring with them clinical manifestations that compromise the functionality of human beings in different spheres, one of them is language, which can affect understanding and / or expression; this pathology is known as aphasia.
Objective: To determine the effectiveness of TEM in the symptom of agrammatism
Clinical case: A 55-year-old male, with right-handed laterality, with a history of brain damage and presented aphasic symptoms, without prior treatment for their symptoms. oral language difficulties, who undergoes 12 intervention sessions with a frequency of three times a week.
Conclusion: The results reveal an increase in oral production in conversational and descriptive speech in information content, fluency, and sentence length.
Implementación de un programa para la prevención y control de las IAAS
Authors: Hernández Torres Francisca Angélica
Published: June 2023

Health Care Associated Infections (HAI), are considered a public health problem, including those conditions that the patient was not incubating prior to hospital admission and that are acquired as a result of clinical care and can extend even after the patient is discharged. In the context of the COVID-19 pandemic, there was an increase in the number of HAIs worldwide due to the demand for health care for critically ill patients.
HAIs are adverse events in clinical care that can evolve into sentinel events resulting in disability or death for the patient; in addition, they have economic implications for the patient, family, and the health sector.
It is necessary to implement measures for the prevention and control of these infections that reduce costs and most importantly, are preventable complications "No one should die from an HAI".
Posthypercapnic syndrome
Authors: Nguyen H. C. , Baranova I. A. , Chuchalin A. G.
Published: June 2023

Hypercapnic respiratory failure is a common cause of hospitalization and death in patients with chronic obstructive pulmonary disease (COPD).

The aim of this work was to analyze the pathophysiological mechanisms and clinical picture of hypercapnic respiratory failure and to discuss the tactics of managing a patient with COPD and posthypercapnic alkalosis that developed during treatment using a clinical case as an example.

Conclusion. To date, the search for new treatments for posthypercapnic alkalosis is still relevant, but there are few published studies on this topic. Acute problems in mixed metabolic disorders can be solved with an integrated therapeutic approach that includes the use of medical gases.
Lymphangioleiomyomatosis: diagnosis of a rare cystic lung disease in a clinical case
Authors: Makarova M. A. , Chernyak A V
Published: June 2023

Sporadic lymphangioleiomyomatosis (LAM) is an orphan disease that primarily affects women of childbearing age. Increasing awareness of this disease among physicians can contribute to its timely diagnosis and treatment.

The aim of this work was to present a case of a young woman with a rare cystic lung disease. At the first visit to the clinic, the patient showed pronounced clinical, radiological and functional changes in the bronchopulmonary system, and a rare pathology was suspected. Establishing the definitive diagnosis in the shortest possible time was essential because pathogenetic therapy with an mTOR inhibitor had to be initiated as soon as the diagnosis of LAM had been clarified. Until 2010, a definitive diagnosis of LAM was made only by surgical lung biopsy. However, there is currently a shift in practice toward less invasive diagnostic methods that eliminate the need for surgical intervention in most patients.

Conclusion. An algorithm for making a definitive diagnosis (sporadic LAM) without morphologic examination of the lung is demonstrated.
Tracheal stenosis and diaphragm relaxation of post-COVID origin
Authors: Bazarov D. V. , Grigorchuk A. Yu. , Kazaryan G. A. , Abdumuradov K. O. , Kabakov D. G.
Published: June 2023

Pandemic of the new coronavirus infection has presented the medical community with challenges that call for immediate action. An increase in the number of severe cases of COVID-19 requiring mechanical ventilation inevitably leads not only to an increase in the complication rates, but also to combined complications. A clinical case of a combined tracheal stenosis and diaphragm after severe COVID-19 is presented here.

The aim of this publication was to improve treatment outcomes of patients with multiorgan complications of post-COVID origin.

Conclusion. Combined complications of a severe coronavirus infection worsen the rehabilitation prognosis, and require surgical treatment.
Indonesian Trade Policy in Adjusting the 2020 WTO’s Trade Policy Review
Authors: Simbolon Putu George Matthew , Damayanti Angel
Published: June 2023

This article analyzes the Trade Policy Review Body (TPRB) review of Indonesia in 2020, mainly in the agricultural sector, and how Indonesian compliance with the WTO Agreement is helpful for the Trade Policy Review Mechanism (TPRM). This study uses the normative method by gathering primary and secondary legal sources. The 2020 TPRB review perceives that Indonesia has applied untransparent safeguard measures related to its agricultural products, prohibited subsidies, and quantitative restrictions on other WTO member states. However, the Job Creation Law, launched in 2020, can be viewed as a proportional law as it puts imported products in an equivalent position with domestic agriculture or food products. The discussions reveal that Law No 11/2020 aims to balance its national interest with the WTO Agreement and the TPRB review of Indonesian trade policy, mainly in agriculture. With such legal certainty, this article recommends that Indonesia consider the TPRB review in good faith by invoking transparent safeguards, reducing its export subsidies on agricultural products, conducting a persistent report to the Committee on Agriculture, and protecting its public health and morals. The Indonesian government should also conduct text mining to determine its trade policies and deal with international trade uncertainty.
Estrategia de sostenibilidad finaciera para proyectos de saneamiento y tratamiento de aguas residuales
Authors: Fernández Diego
Published: June 2023

Esta guía práctica pretende ser de utilidad para orientar a las empresas prestadoras de servicios públicos de saneamiento, a autoridades sectoriales y a consultores que se encuentren en el proceso de identificar, evaluar, desarrollar y operar proyectos de saneamiento, en especifico mediante el desarrollo de los aspectos financieros claves en cada una de las fases de un proyecto de saneamiento. Tambien se incluyen algunos criterios y recomendaciones que apoyan la sostenbilidad financiera de los proyectos de saneamiento a largo plazo.
A Statistical Evolutionary Analysis and Prediction of Carbon-dioxide Emission in Gujarat, Maharashtra and Madhya Pradesh of India
Authors: Dubey Om Prakash , Lal Anamol Kumar , Mondal Kartick , Singh Umashankar
Published: June 2023

Purpose of the study: The change of climate due to global warming has become a burning problem throughout the world. India is a country where global warming causes a concern to the scientists. Unrestricted emission of different green house gases mainly carbon dioxide is responsible for this alarming situation. This paper develops a state-wise nonlinear emission model of carbon dioxide, an important green house gas.

Methodology: Non linear least-square and regression analysis method used to explain the emission of the gas.

Main Findings: The short term and long-term forecast of carbon dioxide emission trend in the states are presented.

Applications of this study: Model is used in the states of Gujarat, Maharashtra and Madhya Pradesh of India.

Novelty/Originality of this study: Future prediction of emission of CO2 may be evaluated from our proposed model. This paper may be helpful for the future researchers for finding emission of CO2 and other GHGs for the remaining states in India.
Responsabilidad penal empresarial: antecedentes y aproximación a la legislación en Colombia
Authors: Ardila Torres Adrián Danilo
Published: June 2023

Los resultados de los estudios evacuados en materia de política crimi­nal han evidenciado la necesidad de realizar verdaderas reformas legislativas a nivel interno y en materia de cooperación internacional con el fin de contrarrestar el impacto negativo que en materia delincuencial vienen mostrando los riesgos derivados de la creación de empresas que se sirven de su poder económico para vulnerar bienes colectivos y de interés para los Estados. El derecho administrati­vo sancionador se ha mostrado ineficiente frente a los retos propuestos por estas personas jurídicas, quienes han utilizado a las distintas formas de asociación para ofrecer una “fachada” de legalidad y perpetrar conductas desviadas en el seno de la sociedad. Por esta razón se muestra como razonable efectuar ingentes esfuerzos por utilizar la ductilidad del derecho y armonizarlo con la realidad social, imple­mentando para el efecto un sistema propio de imputación penal para las personas jurídicas o empresariales.
Lineamientos internacionales y nacionales en materia de responsabilidad penal para adolescentes
Authors: Carvajal Martínez Jorge Enrique
Published: June 2023

Este texto describe los lineamientos desarrollados por el derecho internacional público y el nacional en materia de responsabilidad penal para adolescentes. Inicialmente, se determinan cuáles son los instrumentos en el esce­nario internacional de los derechos humanos, dentro de los cuales se encuentran directrices, convenios y reglas de la Organización de las Naciones Unidas (ONU); así como las directrices establecidas en el Sistema Interamericano de Derechos Humanos (SIDH) frente a la delincuencia juvenil. Posteriormente, se estudian los antecedentes en materia de protección a los niños, niñas y adolescentes (NNA) en el sistema jurídico brasileño y costarricense, lo cual facilita la comprensión del sistema colombiano. Se concluye que, en Colombia, a pesar de la coherencia nor­mativa del ordenamiento, no se ha generado necesariamente la materialización de las garantías legales y de los tratados internacionales.
Consideraciones sobre la colaboración eficaz mediante el principio de oportunidad
Authors: Pardo Monsalve Santiago
Published: June 2023

Las causales 5.ª y 18.ª del artículo 324 de la Ley 906 de 2004 del principio de oportunidad están relacionadas con la colaboración eficaz que el investigado suministra a la Fiscalía General de la Nación para el esclarecimiento de hechos delictivos y la judicialización de sus autores o partícipes. Es una institución que puede traer consigo beneficios en materia de investigación delictiva. Sin embargo, su aplicación no está exenta de inconvenientes. La Fiscalía, por una parte, debe corroborar la información relevante de su colaborador, que vincula a terceras per­sonas en la comisión de delitos. Por la otra, el procesado se afronta al riesgo de que, a pesar de cumplir con sus compromisos con la administración de justicia, no se produzca la renuncia de su acción penal por renuencia del ente acusador. Frente a la primera situación, formularemos una serie de propuestas metodológicas y, en relación con la segunda, sustentaremos la posibilidad de que la defensa acuda ante un juez de control de garantías para que declare por desistida la acción penal.
CAREER PREFERENCE OF THE TURKISH OFFICERS AFTER SEA SERVICE
Authors: SANA Fatih , BAŞAR Ersan , SARIALİOĞLU Songul
Published: June 2023

In this study, the post-maritime careers of Turkish officers who have STCW A-II/1 and A-III/1 qualification at the undergraduate level were investigated, and their new career preferences were examined. The high salary profession has been identified as one of the main reasons why Turkish officers prefer the maritime profession. Turkish seafarers’ working periods on the ship were examined, and the shortness of these durations was observed to be noteworthy. This situation shows that due to not properly career planning, it is seen that they do less sea service because of factors such as family etc. than Filipinos. Therefore, properly planned career management serves both the goals of the institutions and the expectations of the employees. Studies also have shown that a significant majority of the sector's employees aim to have a second career after sea service in the same sector. It is a very remarkable result for the maritime industry that Turkish officers want to work on shore base of the sector. The survey method was used to obtain the data. The regression model in SPSS 22 program was used in the analysis of the obtained data. As a result of this study, it has been observed that most of the Turkish seafarers generally work in the maritime sector after sea services.
MAVİ YOLCULUK SIRASINDA BODRUM GULETLERİ’NDE KULLANIM DAĞILIMININ ARAŞTIRILMASI
Authors: TURAN Bülent İbrahim , ÖZCAN Ahmet
Published: June 2023

Mavi Yolculuk, günümüzde yalnızca Türkiye’de değil tüm dünyada tanınan eşsiz bir deniz turizm türüdür. Gelişen teknolojinin de katkısıyla, müşterilere konforlu ve huzurlu bir tatil imkânı tanıyan Mavi Yolculuk, yerli ve yabancı pek çok turist tarafından tercih edilmektedir. Mavi Yolculuk’ta kullanılan Bodrum Guletleri’nde tasarım, mühendislik ve imalat süreçlerinde müşterilerin kullanım tercihleri büyük önem taşımaktadır. Tüm bu etmenlerin doğru bir şekilde anlaşılabilmesi gerek söz konusu teknelerin daha verimli hale getirilmesi bakımından oldukça kritiktir. Bu araştırmada, Mavi Yolculuk’u tecrübe eden müşterilerin, Mavi Yolculuk’un farklı aşamalarında Bodrum Guletleri’nin çeşitli kısımlarını hangi yoğunlukta kullandığı bilgisini elde etmek hedeflenmiştir. Bu kapsamda amaçlı örnekleme yapılarak Mavi Yolculuk’ta Bodrum Guletleri’nde görev yapmış 10 kaptan ile yapılandırılmış görüşme gerçekleştirilmiştir. Yapılan görüşmelerden toplanan veriler, Mavi Yolculuk’ta kullanılan Bodrum Guletleri’nin özellikle kıç bölümlerinin farklı kullanıcı grupları tarafından aynı anda ve yoğun bir şekilde kullanıldığını ortaya koymaktadır. Bununla birlikte, teknelerin açık alanlarının, kapalı alanlarına kıyasla daha fazla kullanılan bölümler olduğu sonucuna da ulaşılmıştır. Elde edilen sonuçlar, Mavi Yolculuk’ta kullanılan yatların iç mimari kararları da kapsayan tasarım süreçlerine katkıda bulunacak bilgiler sağlamaktadır.
ДЕРЖАВНЕ РЕГУЛЮВАННЯ НАЦІОНАЛЬНОЇ ЕКОНОМІКИ: СТРУКТУРА, МЕТОДИ, СУЧАСНІ ОСОБЛИВОСТІ
Authors: Українська Л. О.
Published: June 2023

Узагальнено сутність державного регулювання як впливу держави на всі складові національної економіки за допомогою законодавчого простору, нормативно-правових актів, правових актів індивідуального регулювання. Розкрито роль здійснення державного контролю за дотриманням вимог законів та нормативно-правових актів, як запоруки ефективності державного регулювання. Систематизовано основні напрями і складові впливу держави на бізнес-процеси у національній економіці, а також критерії, що розмежовують види державного регулювання.
АКТУАЛЬНІ ПРОБЛЕМИ ЦИФРОВОЇ ЕТИКИ БІЗНЕСУ
Authors: Компанієць В. В. , Крацер В. В.
Published: June 2023

В статті наведено визначення сутності цифрової етики бізнесу, основних етичних дилем, проведено системний аналіз проблем та напрямів забезпечення цифрової етики бізнесу на платформі парадигми духовно-моральної та соціокультурної детермінації соціально-економічного розвитку. Розглянуто європейський досвід забезпечення цифрової етики економічних відносин, європейську та вітчизняну законодавчу базу у сфері захисту персональних даних. Висвітлено результати досліджень світових компаній у контексті глобальної кризи довіри до збирачів персональних даних, а також у напрямі  забезпечення цифрової відповідальності бізнесу. Сформовано рекомендації щодо посилення захисту прав людини в кіберпросторі та впровадження в освітянський простір та економічну практику етики економічних  відносин та бізнесу в умовах цифровізації.