bluuebunny/crossref_metadata_2025 huggingface dataset:
Biocompatibility of supercritical carbon dioxide processed poly(lactide-co-glycolide) and poly(ε-caprolactone) assessed with primary human osteoblasts
Authors: Dariš Barbara , Ferk Polonca , Markočič Elena , Knez Željko
Published: February 2023

Purpose: In the present study, poly (lactide-co-glycolide) (PLGA) and poly (ε-caprolactone) (PCL) combined with hydroxyapatite (HA) were processed with supercritical CO2 (scCO2) to obtain macroporous foams.

Methods: The in vitro biocompatibility and mineralization of the foams was assessed with primary human osteoblasts (HOB).

Results: The WST-8 (Water-soluble Tetrazolium salts) test for cell proliferation activity and alkaline phosphatase (ALP) activity assay were used to estimate HOB proliferation and differentiation respectively. The proliferation activity of HOB on foamed PLGA and PCL decreased compared to non-foamed polymer, while on PLGA and PCL foamed constructs with hydroxyapatite (HA), the proliferation activity increased compared to the foamed PLGA and PCL.

Conclusions: The ALP activity on PLGA, PCL and foamed PCL was similar to the control, being less intense on PCL foamed constructs with HA, while foamed PLGA and PLGA foamed constructs with HA showed no evidence of ALP activity.
Burnout
Authors: Rakovec-Felser Zlatka , Pernat Drobež Cvetka
Published: February 2023

This article is devoted to burnout in medical care. Except a definition of phenomenon as a result of imbalance between work demands and resources, physician’s caring for others and caring for oneself, the complex interactions between the external and the internal causes of professional burnout are highlighted. It informs us also with manifestations, signs, and the phases of a triggered burnout process. As North American and European research data in the comparison with the general population reveal higher extent of burnout among physicians, authors emphasize that higher extent of burnout is not only a physicians’ problem, but because of its epidemic character and consequences a vital element of quality and patient outcomes, well–functioning health care system as well as public health in general. They pointed out that the effective prevention programs and helping interventions needs to go in both directions – interventions of medical organization as well as the preventive interventions on an individual level. The latter are presented in the article upon completion.
Myocardial revascularization using the posterior intercostal arteries as grafts: anatomical variation aspect
Authors: Kocbek Lidija , Anderhuber Friedrich
Published: February 2023

Purpose: The posterior intercostal arteries (PIAs) present potential alternative graft sites because of their histological, morphological, and anatomical features. We investigated the anatomical variations of the origin and course of the left fifth and right seventh PIAs, since these arteries have been demonstrated as the most suitable for in situ grafting of the coronary arteries. The aim of this study was to determine whether variations of the PIAs as grafts could influence or limit myocardial revascularization.

Methods: PIAs from the origin to the mid–axillary line were dissected from 44 cadavers embalmed via Thiel's method. The origin and course of the arteries was documented. The lengths of the common trunks, the distances to the costal angle levels, and the diameters of the arteries at the origin, at the point of division from the common trunk, and at the costal angle level were measured to calculate the diameter reduction rate.

Results: Anatomical variations of the left fifth PIA were found in 25% of the cadavers. No variations were found in the right seventh PIAs. The length of the common trunk influences the length of the obtained pedicle. The PIA diameter is dependent on the origin from the aorta. The target PIA should be harvested before the costal angle level to assure a proper diameter of the conduit.

Conclusion: Potential anatomical variations of the PIA must be considered when harvesting a vessel for CABG to avoid technical problems in PIA harvesting and hemodynamic changes.
Large retroperitoneal mass in a 56-year old female
Authors: Arslani Nuhi
Published: February 2023

Purpose: Müllerian ductal cysts are rare congenital abnormalities of Müllerian system regression, typically located in the pelvis . Their presence in retroperitoneum is extremely rare, as the incidence of retroperitoneal cysts, even of diverse morphology and etiology, is approximately 1 in 100,000 adult admissions. Moreover, they can be classified into lymphatic, mesothelial, enteric, and urogenital cysts. Urogenital cysts are further categorized into pronephric, mesonephric, metanephric, and Müllerian types. However, in both sexes the most common location of the Müllerian cyst is in the pelvis; in men they reside mostly near the prostatic utricle and the appendix of the testis. In women, they may be often confused with primary ovarian or tubal cysts.

Case Report: In this case report, we present a case of a benign retroperitoneal cyst of the Müllerian type in a 56- year old female.
Historical overview of breastfeeding in Slovenia
Authors: Mičetić Turk Dušanka , Turk Eva , Šikić Pogačar Maja
Published: February 2023

Breastfeeding is an optimal nutrition that supports the healthy growth and development of infants. Numerous indicators suggest the benefits of breast– feeding to child health during infancy and later in life. Although breastfeeding is highly recommended by European Society for Paediatric Gastroenterology, Hepatology, and Nutrition (ESPGHAN), American Academy of Pediatrics (AAP), World Health Organisation (WHO), United Nations International Children's Emergency Fund (UNICEF) and many others, it may not be always possible, suitable or adequate (i.e. in some metabolic disorders). Human milk was and still is the best food for nearly all infants. Wet nursing was the safest and most common alternative to breastmilk before bottles with nipples and infant milk formulas were invented. Although parents are responsible for decisions on breastfeeding their infants, the role of health care workers, including pediatricians, is to protect, promote, and support breastfeeding. In this article, a historical overview of breastfeeding in Slovenia is presented with a description of the socioeconomic situation in the past.
Folliculotropic mycosis fungoides: Clinicopathological features
Authors: Kovačič Srečko
Published: February 2023

Folliculotropic variant of mycosis fungoides (MF) is a rare type of cutaneous T-cell lymphoma, detected in less than 10% of patients with MF. It occurs mostly in elderly adults, and usually involves the head, neck region, and upper trunk. The diagnosis of this disease is based on a combination of clinical presentation, histology, and T-cell monoclonality. Identification of this variant of disease is important because it may imply worse prognosis and require more intensive treatment.
Higher live birth and lower pregnancy loss rates in natural compared with artificial cycle protocols for endometrial preparation of frozen blastocyst transfer
Authors: Reljič Milan , Mlakar Lea , Hadžimehmedović Azra , Kovač Vilma
Published: February 2023

Purpose: The aim of this study was to compare the reproductive outcomes and live birth rates of natural cycle (NC) and artificial cycle (AC) protocols for endometrial preparation of frozen– thawed embryo transfer (FET).

Methods: A total of 1317 NC and 528 AC protocols for endometrial preparation of FET performed during a 3-year period at a tertiary in vitro fertilisation (IVF) clinic were analysed. The clinical spontaneous abortion, pregnancy, and live birth rates were compared. Logistic regression models were constructed to identify the factors that are significantly associated with the live birth and clinical spontaneous abortion rates.

Results: A significantly lower clinical spontaneous abortion rate (13.68 % vs. 27.32 %; p < 0.001) and a comparable pregnancy and a significantly higher live birth rate (32.82 % vs. 26.70 %; p < 0.01) were associated with the NC compared to the AC protocol. Independent predictors for live birth were maternal age (odds ratio (OR), 0.94; 95% confidence interval (CI), 0.91–0.98), transfer of morphologically- optimal blastocysts (OR, 1.72; 95% CI, 1.28–2.31), and the method used to prepare the endometrium (OR, 0.63; 95% CI, 0.45–0.88). Independent predictors of clinical spontaneous abortion were the method used to prepare the endometrium (OR, 2.26; 95% CI, 1.39–3.68) and maternal age at the time of FET (OR, 1.07; 95% CI, 1.02–1.13).

Conclusions: A better reproductive outcome was observed with the NC protocol; specifically, the clinical spontaneous abortion rate was significantly lower and the live birth rate was significantly higher compared with the AC protocol. Based on better cycle outcomes, patient convenience, and low cost, we suggest using the NC protocol as the first option for FET in patients with regular menses.
Comparison of sensitivity of lung ultrasound and chest x-ray imaging for the diagnosis of community-acquired pneumonia in children
Authors: Berce Vojko
Published: February 2023

Purpose: Lung ultrasound (LUS) has only recently been considered to be a suitable tool for diagnosing community acquired pneumonia (CAP) in children. Little is known about the usefulness of LUS in different types of pneumonia. Therefore, we analyzed and compared the sensitivity of chest X-ray (CXR) and LUS in different etiological types of CAP in children.

Methods: We performed a prospective study in 166 children with CAP, who were admitted to the hospital. The participants were stratified into bacterial (n=80), atypical bacterial (n=32) and viral (n=54) pneumonia subgroups, according to the laboratory and microbiological results. LUS and CXR were performed on all patients at admission.

Results: Pneumonia was detected with LUS in 161 (97.0%) participants and with CXR in 137 (82.5%) participants (p<0.01). The sensitivity of LUS was calculated as 97.0% (95% CI, 93.1%–99.0%), and the sensitivity of CXR as 82.5% (95% CI, 75.9%– 88.0%), p<0.01. In patients with bacterial CAP, infiltrates were detected with LUS in 79 (98.7%) and with CXR in 67 (83.8%) of cases (p<0.01); in atypical bacterial CAP, with LUS in 30 (93.8%) and with CXR in 28 (87.5%) (p=0.69); and in patients with viral CAP with LUS in 52 (96.3%) and with CXR in 42 (77.8%) (p<0.01).

Conclusion: We have determined that LUS is an excellent tool for diagnosing CAP in children. LUS is at least as sensitive as CXR in all types of CAP in children and will probably replace it as the investigation of choice in CAP.
Polyarteritis nodosa in a 6-year-old girl – a case report and overview of current management techniques of the disease in paediatric patients
Authors: Marčun Varda Nataša , Močnik Mirjam
Published: February 2023

Purpose: In this article a rare case report of a 6-year-old girl with polyarteritis nodosa (PAN) is presented and current clinical and treatment recommendations and new research data are reviewed. The latter is needed to clearly describe disease presentation, treatment responses, and prognosis in children. PAN is a rare form of vasculitis in children, affecting medium- and smallsized arteries. Its clinical presentation can be quite unspecific and insidious at the beginning, presenting a diagnostic problem.

Methods: Presentation of the patient clinical characteristics, results of the investigation and treatment carried out, as well as the approach to management, treatment, and monitoring of patients with the same condition.

Results: Patient diagnosis was confirmed by laboratory and morphological diagnostics. Treatment with corticosteroids and mycophenolate mofetil was introduced, which led to clinical improvement. The patient requires further lifelong follow-up. Conclusions: Early diagnosis and timely initiation of treatment are of the utmost importance for good prognosis and prevention of devastating irreversible impairment caused byPAN. New multicentre research is needed to improve the treatment of rare paediatric patients with this condition.
Impact of Combined Continuous Treatment on the Symptoms and Quality of Life of Children with Attention Deficit Hyperactivity Disorder: A Prospective Observational Study
Authors: Venek Saška , Gregorič Kumperščak Hojka
Published: February 2023

Purpose: Although attention deficit hyperactivity disorder (ADHD) is one of the most common neurodevelopmental disorders, studies involving the long-term treatment effects on symptoms and quality of life (QOL) are few in number and the results are conflicting. The purpose of the current study was todetermine the effect of combined (pharmacologic and non-pharmacologic) continuous treatment on the symptoms and QOL in children with ADHD after initial stabilization of symptoms.

Methods: Seventeen children with ADHD (mean age = 8.5 years; 15 boys and two girls) were included in this prospective observational study. The children were assesed at baseline and 9 months later based on the ADHD Rating Scale (RS), Clinical Global Impression-Severity (CGI-S), and Child Health and Illness Profile/Parent Report Form-76 (CHIP-CE).

Results: After 9 months of treatment, the ADHD RS showed improvement in symptoms in two items closely related to attention (p <0.05); the global value remained unchanged. Furthermore, the CGI-S showed improvement in the severity of ADHD (p <0.05). CHIP-CE showed stability and > 50% improvement in the QOL among participants in four of five domains with no statistically significant difference.

Conclusion: The results of this study suggested that continued treatment of ADHD was justified after initial stabilization of symptoms and further improvement in symptoms and QOL can be expected.
Surgical treatment in severely immunocompromised patient with invasive fungal infection
Authors: Skok Kristijan , Vidovič Damjan , Gačevski Goran , Veingerl Bojan , Auda Jure , Crnjac Anton
Published: February 2023

Purpose: We present a case report of successful surgical treatment of a 58-year- old severely immunocompromised male patient with invasive fungal infection.

Case presentation: A 58-year-old male with a smoking history of 30 years was admitted to hospital because of sudden shortness of breath. Radiographic imaging showed an extensive pneumothorax. The patient had a history of T-cell lymphoma, B-cell MALT lymphoma, and chronic obstructive pulmonary disease. He had also previously undergone chemotherapy. During hospitalization, his health state started to deteriorate. On the basis of imaging and microbiological culture results, he was diagnosed to have a fungal infection with Aspergillus fumigatus. After careful preoperative care, preparations, and several consultations, we performed video-assisted thoracic surgery. Because  of poor visibility, inaccessibility, and rupture of an intercostal artery, we performed thoracotomy with excision of the right lung apex. Histopathology and microbiology results confirmed the initial diagnosis. Postoperatively, a 1-year treatment regimen with voriconazole was introduced. The follow-up CT scan showed no signs of fungal infection progression. The patient was given further instructions and discharged from the hospital in a cardiorespiratory compensated state.

Conclusion: Despite poor prognostic factors, the surgical procedure was successful and the patient’s health state considerably improved.
Role of human papillomavirus self-sampling in cervical cancer screening
Authors: Bokan Teodora , Takač Iztok , Repše Fokter Alenka , Ivanuš Urška , Jerman Tine , Arko Darja
Published: February 2023

Cervical cancer screening has successfully reduced the incidence and mortality of cervical cancer in many countries. In Slovenia, the incidence of cervical cancer decreased in 2003–2015 by almost 50%. Participation in screening has reached about 72% over the last 3 years. The main cause of cervical cancer is infection with human papillomaviruses (HPVs). For this reason, in 2010, HPV testing was included in the national screening programme ZORA for triage of low-grade lesions and as a test of cure in 2010. Even though screening is free ofcharge and accessible in Slovenia, about 30% of women still do not respond to invitations and are not screened regularly, especially women aged 50–64 years. HPV self-sampling could improve the detection of precancerous changes among non-attenders of the cervical cancer screening program. By using a validated PCR HPV DNA test, cervical and vaginal HPV sampling have similar accuracy for the detection of CIN 2+, resulting in the same or higher accuracy than the Pap test. Women describe HPV self-sampling as user-friendly, intimate, less embarrassing, and less painful than the Pap smear. About one-quarter to one-third of non-attenders of regular screening responded to the invitation to perform self-sampling. In a Slovenian randomised trial, the overall response rate was more than one-third and was not much higher in an opt-outcompared to opt-in approach. HPV self-sampling could lead to an improvement in the detection of precancerous cervical lesions. European guidelines for quality assurance on cervical cancer screening recommend HPV self-sampling in women who do not attend regular cervical screening programmes.
Effects of intravenous and inhalation induction of anesthesia on oxygen delivery in elderly patients undergoing colorectal surgery
Authors: Mekiš Dušan , Sok Vesna
Published: February 2023

Purpose: The induction of anesthesia with direct laryngoscopy and orotracheal intubation are two interventions, which can influence oxygen delivery. Rapid adjustments of treatment to restore oxygen delivery are crucial to improving the outcomes for patients. The aim of this study was to compare the effects of induction of anesthesia with propofol and sevoflurane on oxygen delivery in elderly patients undergoing colorectal surgery. Methods: We studied forty patients with physical status II or III, according to the American Society of Anesthesiology,who were older than 65 years and undergoing elective surgery for resection of colorectal carcinoma. The patients were randomly divided into the propofol group (P-group) and sevoflurane group (S-group), according to the anesthetic received for the induction of anesthesia. Results: After induction of anesthesia, heart rate, mean arterial pressure, cardiac output and the oxygen delivery index significantly decreased in both groups compared to the baselinevalues. Following induction of anesthesia, the decrease in heart rate was significantly more rapid in the P-group. Immediately after orotracheal intubation, heart rate, mean arterial pressure, cardiac output and the oxygen delivery index significantly increased in the S-group, but one minute later these diferences were not statistically significant. Heart rate, meanarterial pressure, cardiac output and the oxygen delivery index were significantly lower after orotracheal intubation in both groups, compared to baseline.Conclusion: Prpofol and sevoflurane are clinically comparable in the induction of anesthesia in elderly patients according to the effect on oxygen delivery.
Prolonged, recurrent, spontaneous massive gluteal and femoral bleeding in a patient with five metachronous primary malignancies
Authors: Čretnik Andrej , Šumer Pia , Breznik Silva
Published: February 2023

Purpose: This study aimed to present the case of prolonged, recurrent, spontaneous massive bleeding in a patient with five metachronous primary malignancies.

Case presentation: A 70-year-old male patient presented with massive hematomas in the gluteal and femoral regions and a 6-year  history of prostatic, urethral (penile), right colonic, and right pulmonary carcinoma, with a myeloproliferative disease that recently ended with lymphatic leukemia. Fasciotomies with the evacuation of massive hematomas were performed due to the development of compartment syndrome, which were followed by persistent recurrent bleeding. Despite several surgical interventions with packing, local hemostatic agents and sutures, and selective embolization with immediate clinical discontinuation of bleeding, the digital subtraction angiography showed recurrent bleeding from the peripheral branches of the internal iliac and deep femoral arteries always a few days after the procedures. The coagulation and aggregation parameters and bleeding disorders tests were within normal ranges. The histology showed no malignancy in the affected regions, and no relapse was reported in any regions with previously operated malignant diseases on control computed tomography and positron emission tomography scans.

Conclusion: We could stop the bleeding only with more aggressive, nontarget gradual embolization. Subsequently, hemostasis was achieved, with gradual healing of incisions.
Outcomes of physical therapy in patients with chronic low back pain
Authors: Klemenc Ketiš Zalica
Published: February 2023

Purpose: To assess the outcomes of a10–treatment sessions program of physical therapy regarding the level of pain and health–related quality of life in patients with chronic, non–specific, low back pain.Methods: A consecutive sample of adults (N = 129) with chronic, non–specific, low back pain was assessed for improvement after a 10–day physical therapy program, consisting of an average of 3 different physical modalities, as prescribed by family physicians. A visual analog pain scale and EuroQol questionnaire (EQ–5D and EQ–VAS) were completed by patients before and after physical therapy.Results: The intensity of pain after 10 days of physical therapy was on average lower (1.7 ± 1.8 points; P < 0.001). The assessment of overall health on the EQ–VAS was on average better (10.3 ± 15.2 points; P < 0.001). The score of the EQ–5D was on average lower (0.8 ± 1.2 points; P < 0.001). The patients that were not on sick leave during the physical therapy reported a greater lowering of the intensity of pain than those on sick leave (P = 0.03). Patients with a BMI > 29 kg/m2 had a significantly higher change in the assessment of overall health on the EQ–VAS (P = 0.022). The patients that had group exercise in the set of procedures reported a greater improvement in overall health on the EQ–VAS compared to the patients that didnot have group exercise (P = 0.036). The patients with anxiety and depression had a significantly higher change in the composite score of the EQ–5D (P = 0.013). Patients with a BMI > 29 kg/m2 had a significantly higher change in the composite score of the EQ–5D (P = 0.013).Conclusion: Physical therapy has some effect in the short–term treatment of patients with chronic, non–specific, low back pain, but the viability of such procedures in this population of patients is questionable.
About some ethical perplexities of modern medicine / O nekaterih etičnih zadregah sodobne medicine
Authors: Trontelj Jože
Published: February 2023

I greatly appreciate being invited to a gathering of such eminent researchers. A series of international conferences entitled “Medicine and Law” organized by the University of Maribor has enabled dialogue between professionals in medicine and in law. The benefits go beyond this dialogue. The conferences have been an opportunity for self–reflection in both areas and for in-depth analyses of some of the important ethical and legal questions of our time.
Comparison of microvessel density and PSA level in prostatic adenocarcinoma of Gleason score 6 and 7
Authors: Dariš Barbara , Munda Miha , Hajdinjak Tine , Kavalar Rajko , Štiblar-Martinčič Draga
Published: February 2023

Purpose: The aim of our investigation was to determine differences in microvessel density (MVD) and serum levels of prostate-specific antigen (PSA) between groups of patients with Gleason score (GS) 6 adenocarcinoma and patients with GS 7 adenocarcinoma.

Methods: The study was done in a series of 26 patients with prostatic adenocarcinoma. Specimens were divided into two groups: GS 6 (13 cases) and GS 7 (13 cases). Intratumoral microvasculature was highlighted by immunohistochemical means using an antibody against endoglin. Endoglin stained microvessels in and around the tumor but showed weak or no staining for bloodvessels in non-neoplastic tissue. Areas of maximal angiogenesis within the tumor were identified and microvessels counted at ×400 magnification (0.19 mm2 field).

Results: The GS 6 group had lower MVD per field(19.9 vs. 25.6; P=0.05) and MVD per mm2 (89.7 vs. 117.7; P=0.05) when compared with the GS 7 group. No significant difference in mean serum levels of PSA between the two groups was observed (5.7 vs. 10.2 ng/ mL; P=0.10). MVD per mm2 was not correlated with PSA (r=0.20; P=0.30). The age of patients at diagnosis was significantly lower in cases with GS 6 prostatic adenocarcinoma (61.2 vs. 66.2 years; P=0.01).

Conclusion: Our preliminary results suggest a possible difference in the neovascularization between the two groups of specimens, but a difference in PSA level was not proved. Nevertheless, a future large-scale study is needed to confirm these findings.
Znanstvenoraziskovalna dejavnost Univerze v Mariboru in pogled v prihodnje / The University of Maribor’s scientific research activities and a look into the future
Authors: Klainschek Karin Stana
Published: February 2023

Spremenjene družbenoekonomske razmere soočajo Univerzo v Mariboru (UM) z novimi izzivi, ki se nanašajo tudi na organizacijo znanstvenoraziskovalnega dela na Univerzi. V prihodnjem obdobju bo potrebno večje povezovanje med posameznimi znanstvenoraziskovalnimi vedami in področji, z namenom doseganja znanstvene odličnosti, višje kakovosti življenja, večje gospodarske rasti regije in s tem trajnostnega razvoja. Univerzitetno okolje omogoča akademsko svobodo, pospešuje kreativno mišljenje in pomaga pri snovanju in uresničevanju novih izvirnih znanstvenih idej, ki niso vedno usmerjene k neposrednemu ustvarjanju nove dodane vrednosti izdelkov in tehnologij. Na drugi strani, zaradi vse večjih zahtev po doseganju višje gospodarske rasti, ponuja razvojno–industrijsko okolje kreativno okolje, ki pa je usmerjeno ciljno na razvoj določenega izdelka. Na poti ustvarjanja in razvoja našega okolja in višje kakovosti življenja ter v skladu z glavnimi znanstvenoraziskovalnimi in razvojnimi usmeritvami evropske skupnosti stopamo skupaj, vsak s svojimi prednostmi in pomanjkljivostmi. Vloga Univerze v tem procesu je povezovalna in koordinacijska z namenom doseganja sinergijskih in trajnostnih učinkov. Vizija, poslanstvo in strategija znanstvenoraziskovalnega dela UM opredeljujejo združevanje poučevanja in raziskovanja, povezovanja različnih področij in dejavnosti ter boljšega in učinkovitejšega prenosa in souporabe znanja.
Follow–up of females with atypical glandular cells on Pap smears
Authors: Planinc Ana , Repše Fokter Alenka , Golouh Rastko
Published: February 2023

Purpose: Atypical glandular cells (AGC) are often associated with clinically significant lesions, but the interpretation of AGC and the associated lesions on Pap smears remains challenging, even for experienced cytopathologists. The frequency and histologic follow–up of AGC regardless of gland cell type were investigated.

Methods: A retrospective review was conducted involving 199,265 cervicovaginal smears which were examined in the Department of Pathology and Cytology of Celje General Hospital between 1 January 2003 and 31 December 2008. We investigated the frequency of AGC on conventional Pap smears and evaluated the follow–up and correlation between cytology results and subsequent biopsy diagnoses over a 6–year period. The data were processed using the statistics program, SPSS. Statistical significance was set at a p<0.05.

Results: Between 1 January 2003 and 31 December 2008, a total of 745 women had AGC, representing 0.4% of all Pap smear results. One hundred seventy–two women (23.1%) with an average age of 41 years (range, 17–65 years) had a subsequent histologic examination. There were 79 patients (45.9%) with a clinically significant diagnosis, including 63 patients with high– grade cervical intraepithelial neoplasia, 4 patients with adenocarcinoma in situ, and 12 patients with invasive carcinoma (5 endometrial adenocarcinomas, 5 cervical squamous carcinomas, and 2 other types). Normal histologic findings were present in 65 patients (37.8%), 26 patients had low–grade cervical intraepithelial neoplasia, and 2 patients had low–grade glandular intraepithelial neoplasia.

Conclusion: In subsequent biopsy specimens, cytologically AGC are not always glandular or even abnormal. The underlying abnormalities are often so serious that AGC findings require careful clinical and histologic follow–up.
Cell Physiology in Tissue Slices Studying Beta Cells in the Islets of Langerhans
Authors: Stožer Andraž , Dolenšek Jurij , Skelin Klemen Maša , Slak Rupnik Marjan
Published: February 2023

Isolated endocrine cells have enabled the development of numerous methods to assess basic cellular architecture and define a significant part of the molecular machinery involved in cellular processes, such as excitability or the exocytotic release of hormones following cytosolic calcium increase. These efforts have generated consensus models explaining the activation or general operation of a particular cell type. The use of fresh tissue slices can go even further and uncover a series of emergent properties never explained orpredicted by consensus models. In this paper, we present a selection of our most important experimental findings in the beta cells of pancreatic tissue slices.
Ultrasonographic and classical risk factors of carotid atherosclerosis in patients with type–2 diabetes mellitus
Authors: Šantl Letonja Marija , Letonja Mitja , Nikolajević Starčević Jovana , Petrovič Danijel
Published: February 2023

Purpose: We determined the prevalence of the clinical and biochemical risk factors as well as the extent of atherosclerosis in carotid arteries in patients with diabetes mellitus type 2 (DMT2).

Methods: A total of 289 subjects with DMT2 and 157 healthy subjects were enrolled in this prospective cross–sectional study. Levels of total cholesterol, high–density lipoprotein– cholesterol (HDL–C), low–density lipoprotein–cholesterol (LDL–C), triglycerides, fasting blood glucose, fibrinogen, and high–sensitivity C–reactive protein (hsCRP) were measured using standard biochemical methods. Carotid atherosclerosis was assessed by ultrasonography. Intima media thickness (IMT), plaque type and plaque score were also determined.

Results: In comparison with healthy controls, DMT2 patients: were older and had a larger waist circumference; higher body mass index; higher prevalence of hypertension; higher values of fibrinogen, D–dimer, glucose, hsCRP, troponin and triglycerides. Patients with DMT2 had lower levels of LDL–C and they were treated more often with statins (70% vs. 5%). In comparison with healthy subjects, patients with DMT2 had an increased intima media thickness (1.09±0.12 vs. 0.98±0.14; P=0.001), higher plaque score, and more advanced types of plaques.

Conclusion: In comparison with healthy subjects, patients with DMT2 had an increased carotid IMT and higher plaque burden.
Treatment of uterine sarcomas at the Maribor University Clinical Centre between 1996 and 2011
Authors: Arko Darja , Dovnik Andraž , Takač Iztok
Published: February 2023

Purpose: Uterine sarcomas are rare malignant tumours with a worse prognosis than endometrial carcinomas. This retrospective study was performed to determine the clinical and histologic characteristics, treatment, and outcomes in uterine sarcoma patients treated at our hospital over a 16–year period.

Methods: Twenty–two patients (median age, 60.5 years) with uterine sarcomas were treated at our facility between 1996 and 2011. Information was collected from hospital and follow–up records and from the Cancer Registry of Slovenia. All tumours were classified according to the new FIGO classification for uterine sarcomas.

Results: The majority of the patients presented with postmenopausal bleeding. The most common histologic subtype was leiomyosarcoma (50%), followed by carcinosarcoma (40.9%), and endometrial stromal sarcoma (9.1%). All of the patients were initially treated surgically, 21 by laparotomy and 1 laparoscopically. Eight patients were treated with post–operative radiotherapy and 4 patients received post–operative chemotherapy. Disease progression was observed in 8 of 17 patients who had sufficient follow–up information for this analysis. The 5–year overall survival was 44%.

Conclusion: The overall survival of patients treated for uterine sarcomas in our study was comparatively good. Due to the small number and heterogeneity of the patients, larger multi–centre trials are needed for a reliable analysis of factors influencing patient survival.
Cardiovascular mortality and microinflammation in abdominal obese hemodialysis patients
Authors: Bevc Sebastjan , Zorman Tadej , Purg Darinka , Ekart Robert , Hojs Radovan
Published: February 2023

Purpose: Abdominal adipose tissue has important inflammatory properties and is a source of various inflammatory mediators. Given that concentrations of some inflammatory mediators are high among hemodialysis (HD) patients, abdominal obesity may play an important role in the pathogenesis of microinflammation which is known to be associated with accelerated atherosclerosis. The aim of our study was to determine the impact of microinflammation on cardiovascular (CV) mortality in abdominal obese HD patients.

Methods: Seventy–one HD patients (mean age 59.3 ± 12.8 years) were included in our study. Waist circumference (WAC) was measured and abdominal obesity was defined according to the International Diabetes Federation. Serum levels of lipids (triglycerides, high density lipoproteins (HDL) cholesterol, low density lipoproteins (LDL) cholesterol) and inflammatory mediators (interleukin–6, tumor necrosis factor–alpha, vascular cellular adhesion molecule–1 (VCAM–1), intercellular adhesion molecule–1 (ICAM–1)) were measured. Patients were observed from the date of measurement (November 2003) of inflammatory mediators until their death or to 10th of November 2009.

Results: The mean WAC value for men was 97.6 ± 16.1 cm, and for women 92.2 ± 15.9 cm. Abdominal obesity was found in 62% of the enrolled patients. Cox regression analysis showed that the inflammatory mediators VCAM–1 (p<0.031) and ICAM–1 (p<0.024) were predictors of CV mortality in abdominal obese HD patients. Both inflammatory mediators remained predictors of CV mortality if age and other known risk factors for atherosclerosis (arterial hypertension, smoking, HDL and LDL cholesterol and triglycerides) were included in the analysis.

Conclusion: The results of our study indicate that microinflammation is associated with CV mortality in abdominal obese HD patients.
Małgorzata Kowalska, Dialektyka poza dialektyką. Od Bataille'a do Derridy, Aletheia, Warszawa 2000, s. 400.
Authors: Pietrzak Jacek
Published: February 2023

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Pengembangan Kawasan Pariwisata Malioboro dengan Menggunakan Konsep Heritage dan Teras Budaya
Authors: Wahyu Firda , Amalia Khorina Dwi Disti , Wahyu Gusti Kinanti , Maulana Irham Zulfi , Susila Rheynaldi Lintang
Published: February 2023

Pariwisata perkotaan (urban tourism) merupakan bentuk pengembangan pariwisata dengan lokasi wisata yang berada di area atau dalam kota, elemen-elemen kota bahkan kota itu sendiri menjadi daya tarik utama pariwisata (Prijadu dkk, 2014). Salah satu satu kota yang memiliki potensi dan pengembangan pariwisata adalah Malioboro, dimana kawasan tersebut sudah lama dikenal sebagai pusat destinasi wisata dan jantung kota Yogyakarta. Pada artikel ini, akan dibahas mengenai analisis dan konsep pengembangan Urban Tourism pada kawasan Pariwisata Malioboro. Hasil dari pembahasan pada artikel ini terdapat tiga bahasan. Hasil pembahasan pada artikel ini diantaranya: 1) Kondisi wisata yang ada di malioboro berdasarkan sejarahnya lokasi ini dijadikan tempat pariwisata karena lokasinya yang merupakan pusat pemerintahan sehingga banyak terjadi aktivitas di dalamnya hingga berkembang menjadi sektor pariwisata hingga saat ini, kawasan wisata Malioboro juga merupakan kawasan perdagangan dan jasa dan berdekatan dengan objek-objek pariwisata lainnya 2) terdapat 6 ide pengembangan pada kawasan Urban Tourism Malioboro yang didapat dari hasil analisis. 3) Terdapat berberapa konsep yang dapat diterapkan di kawasan Pariwisata Malioboro yaitu konsep Heritage Tourism dan konsep Teras Budaya.
Perencanaan Ekowisata Kampung Blekok Berbasis Community Based Tourism (CBT)
Authors: Trispa Erlisa Rika , Kaloka Darmawan Bagus , Harmadi Cantya Khansa , Puspamika Selgi , Rizqullah Ghani
Published: February 2023

Pengembangan kawasan kampung wisata saat ini menjadi alternatif pengembangan ekonomi lokal dan industri kreatif yang telah diterapkan di berbagai daerah. Salah satu kampung yang dikembangkan sebagai objek kampung ekowisata adalah kampong blekok yang terletak Desa Klatakan, Kabupaten Situbondo, yang memiliki potensi berupa tanaman bakau dan mangrove yang cukup luas mencapai 5 hektar. Selain itu keberadaan burung blekok yang menempati hutan mangrove cukup membuat kawasan ini menjadi lebih eksotis. Obyek wisata kampong blekok ini berlokasi di tepi jalur pantura Surabaya-Banyuwangi tidak jauh dari tugu 1000 km anyer panarukan. Jalan utama menuju kawasan ini merupakan jalan nasional dengan perkerasan aspal. Dalam pengembangan wisata kampong blekok ini perlu mengkaji sistem kepariwisataan yang terdiri dariberbagai aspek, sehingga penelitian ini memiliki tujuan untuk mengeksplorasi potensi untuk pengembangan Kampong Blekok sebagai daya tarik pariwisata alam yang ada di pedesaan (rural tourism) sehingga dapat menjadi rekomendasi bagi pengembangan Kampung Blekok kedepannya. Hasil dari penelitian menunjukkan bahwa secara umum potensi kampung wisata blekok ini cukup beranekaragam. Beberapa permasalahan yang ditemukan seperti kualitas sumber daya manusia, sarana dan prasarana, serta promosi yang belum optimal. Permasalahan yang ditemukan tersebut dapat diatasi dengan peran serta aktif dari berbagai pihak terutama masyarakat kampung ekowisata dan budaya setempat.
Analisa Tingkat Kerentanan Banjir Berbasis SIG pada Kecamatan Sumbersari, Kabupaten Jember
Authors: Aprilia Sonia Nuri , Hayati Nunung Nuring , Alfiah Rindang
Published: February 2023

Berdasarkan DIBI, bencana banjir di Kabupaten Jember memiliki persentase tertinggi dibandingkan dengan bencana alam lainnya, yaitu 59,34 %. Menurut BPBD Kabupaten Jember, salah satu kecamatan yang berpotensi tinggi terjadi banjir adalah Kecamatan Sumbersari. Berdasarkan data terbaru, banjir yang terjadi di Kecamatan Sumbersari setinggi 25 – 150 cm yang mengakibatkan rusaknya 13 bangunan rumah, 1 mushallah, dan sarana prasarana umum lainnya. Melihat riwayat terjadinya banjir di Kecamatan Sumbersari yang mengakibatkan kerugian terus meningkat disetiap tahunnya dan didukung dengan tidak adanya peraturan tata ruang yang membahas mengenai penanganan meminimalisir banjir di Kecamatan Sumbersari, bukan tidak mungkin lagi potensi banjir di kecamatan Sumbersari semakin meningngkat. Maka drai itu, penelitian ini bertujuan untuk mengetahui tingkat kerawanan banjir menggunakan analisis overlay dan merumuskan prioritas penanganan banjir di Kecamatan Sumbersari dengan menggunakan teknik analisis analisis hierarki proses (AHP). Berdasarkan hasil analisis overlay diketahui kerawanan banjir di Kecamatan Sumbersari terklasifikasi menjadi tiga (3), yaitu tingkat kerentanan rawan (rendah), cukup rawan (sedang), dan sangat rawan (tinggi). Prioritas penanganan banjir di Kecamatan Sumbersari berdasarkan metode struktural dapat dilakukan dengan pengembangan dan normalisasi saluran drainase, pembangunan hutan kota, pembangunan sumur resapan, serta pembuatan waduk retensi. Sedangkan berdasarkan metode non struktural, prioritas penanganan meminimalisir banjir di Kecamatan Sumbersari dapat dilakukan dengan pengelolaan dan penyediaan tempat sampah dan perencanaan pertanian dengan konsep agroforestri.
Mitigasi Daerah Rawan Bencana Longsor Berbasis Pemetaan Sistem Informasi Geografis di Kecamatan Bumiaji
Authors: 'Aina Corry , Nurjahjaningtyas Indra , Alfiah Rindang
Published: February 2023

Salah satu wilayah terluas di Kota Batu dengan tingkat kerawanan bencana longsor tertinggi terletak di Kecamatan Bumiaji (Noorwantoro, 2014). Berdasarkan RTRW  Kota Batu Tahun 2010-2030, beberapa desa yang digunakan sebagai kawasan hunian di Kecamatan Bumiaji berada pada kawasan rawan bencana. Hal ini tidak sesuai dengan Peraturan Menteri Pekerjaan Umum dan Perumahan Rakyat Nomor 41/PRT/M/2007 tentang Pedoman Kriteria Teknis Kawasan Budidaya bahwa kawasan yang boleh digunakan sebagai permukiman tidak berada pada daerah rawan bencana, seperti tanah longsor, banjir, erosi, dan abrasi. Tujuan dilakukan penelitian adalah untuk mengidentifikasi daerah rawan longsor di Kecamatan Bumiaji dan menentukan prioritas upayaamitigasiiyangidapat dilakukan. Metode analisis yang digunakan dalam melakukan pemetaan adalah overlay, sedangkan dalam penentuan prioritas upaya mitigasi dilakukan dengan metode AHP (Analytical Hierarchy Process). Berdasarkan hasil analisis, diketahui bahwa Kecamatan Bumiaji merupakan salah satu kecamatan di Kota Batu yang termasuk kedalam daerah rawan bencana tanah longsor. Pemetaan daerah rawan bencana longsor yang dilakukan dengan overlay 4 paramaeter peta curah hujan, jenis tanah, penggunaan lahan dan kelerengan menghasilkan klasifikasi daerah rawan bencana longsor. Daerah dengan kerawanan rendah seluas 24,2 %, sedang seluas 37,7 %, tinggi seluas 35,3 % dan sangat tinggi seluas 2,8% dari total Kecamatan Bumiaji. Prioritas utama mitigasi bencana yang sesuai dengan karakteristik wilayah Kecamatan Bumiaji adalah pemetaan daerah rawan bencana, kemudian dilanjutkan dengan pendidikan dan pelatihan SDM, pembuatan prediksi bencana, pembuatan jalur dan rambu evakuasi dan pembentukan satuan tugas.
Penentuan Prioritas Pengembangan Infrastruktur Wilayah Pesisir Kecamatan Muncar Menggunakan Metode Importance – Performance Analysis (IPA)
Authors: Adela Aurelia Zara , Hasanuddin Akhmad , Alfiah Rindang
Published: February 2023

Kecamatan Muncar merupakan salah satu kecamatan yang berada di ujung timur Kabupaten Banyuwangi, Provinsi Jawa Timur yang berbatasan langsung dengan Selat Bali. Kecamatan Muncar memiliki potensi yang beragam, berdasarkan RTRW Kabupaten Banyuwangi tahun 2012 – 2032 ditetapkan sebagai Kawasan Minapolitan dan Wilayah Pengembangan Pariwisata II dengan image wisata spiritual dan wisata bahari. Akan tetapi pada kondisi eksisting infrastruktur yang ada dinilai masih kurang mendukung kegiatan di Pesisir Muncar, sehingga terdapat permasalahan antara lain: pencemaran lingkungan, bau tidak sedap, banyaknya sampah di kawasan Pantai Muncar, sering terjadi abrasi pantai, serta kurangnya lampu penerangan. Selain itu, pada infrastruktur perikanan juga belum optimal, antara lain: akses menuju TPI Brak Kalimoro jalannya sempit dan belum beraspal, pengangkut ikan yang rendah, dermaga yang ada di Pelabuhan Perikanan belum berfungsi dan SPBN yang beroperasinya tidak menentu. Sehingga penelitian ini memiliki tujuan untuk mengetahui prioritas pengembangan infrastruktur wilayah Pesisir Muncar dan memberikan arahan pengembangan infrastrukturnya. Metode penelitian ini menggunakan pendekatan rasionalistik serta jenis penelitiannya adalah kuantitatif dan kualitatif. Pada penentuan prioritas pengembangan infrastruktur wilayah pesisir Kecamatan Muncar menggunakan teknik Importance-Performance Analysis (IPA) dan untuk menentukan arahan pengembangan infrastruktur menggunakan analisa triangulasi. Berdasar hasil penelitian, dapat diketahui prioritas infrastruktur, ialah: prioritas 1 (sistem pengelolaan limbah dan sanitasi, persampahan, drainase, dan jaringan jalan), prioritas 2 (fasilitas pendukung transportasi, cold storage, pabrik es, Stasiun Pengisian Bahan bakar Nelayan, dan Tempat Pelelangan Ikan), dan prioritas 3 (puskesmas, Koperasi Unit Desa, rumah makan, dan hotel atau homestay).
Dampak Eksternalitas Pabrik Ikan terhadap Permukiman di Desa Kedungrejo Kecamatan Muncar dengan Pendekatan Pembangunan Berkelanjutan
Authors: Arrochimi Dewi Rizqi , Dhokhikah Yeny , Aji Rendra Suprobo
Published: February 2023

Kabupaten Banyuwangi memiliki daerah penyumbang perikanan laut terbanyak yaitu Kecamatan Muncar. Hal tersebut mengakibatkan wilayah Kecamatan Muncar memiliki industri pabrik ikan terbanyak di Kabupaten Banyuwangi. Daerah di Kecamatan Muncar yang memiliki pabrik ikan terbanyak yaitu di Desa Kedungrejo. Namun secara eksisting pabrik ikan di Desa Kedungrejo berdampingan langsung dengan permukiman dan bertentangan dengan peraturan dan regulasi yang ada. Permukiman dengan pabrik ikan tidak dapat dipisahkan karena sebagian besar masyarakat sekitar berkerja dan bergantung pada pabrik ikan, sehingga terjadi tumpang tindih pemanfaatan ruang yang menyebabkan dampak eksternalitas. Diperlukan kajian untuk penanganan dari dampak eksternalitas tersebut. Penelitian ini menggunakan 3 tahap analisis yaitu menggunakan metode analisis wawancara semiterstruktur, analisis korelasi lalu analisis triangulasi. Hasil penelitian ini yaitu diketahui faktor penyebab dampak eksternalitas di Desa Kedungrejo akibat adanya sumberdaya bersama, barang publik, dan penyelewengan kebijakan. Selain itu pada analisis korelasi didapatkan bahwa aspek lingkungan dengan aspek ekonomi memiliki korelasi negatif, pada aspek lingkungan dengan aspek sosial memiliki korelasi positif, dan aspek ekonomi dengan aspek sosial memiliki korelasi negatif. Adapun penanganan dampak eksternalitas ini yaitu peningkatan monitoring baku mutu limbah, sosialisasi kepada pelaku usaha pabrik ikan skala sedang dan kecil, pembangunan IPAL bagi pabrik yang limbahnya melibih baku mutu dan jika kurang mampu dapat mengajukan bantuan kepada pemerintah, mempertegas peraturan terkait, pemberian sanksi administratif bagi pabrik yang melanggar, dan pemberian insentif kepada pelaku industri yang membuka lapangan perkerjaan bagi masyarakat sekitar.
Parental Consanguinity and Risk for Childhood Hearing Loss: A Retrospective Cohort Study
Authors: Leal Bárbara , Lopes Ana Cristina , Peixoto Daniela , Correia Laura , Almiro Maria Miguel , Vilar João , Azevedo Maria Luísa , Bicho Maria Adelaide
Published: February 2023

Introduction: Genetic causes are responsible for half of the cases of hearing loss, most of them being the result of non-syndromic genetic changes resulting from autosomal recessive inheritance. Parental consanguinity might be an indicator to consider in the diagnosis of these cases. The aim of this study was to assess its importance as a risk factor for childhood hearing loss.Material and Methods: A retrospective cohort study conducted in a district hospital, between 2014 and 2018. We included all live births born during this period and excluded those with risk factors for childhood hearing loss other than parental consanguinity and those without hearing screening. We formed two study groups: newborns with parental consanguinity and newborns without risk factors. All the participants underwent hearing screening with the primary outcome of this study being the result of the screening. Those with a not normal result or with parental consanguinity also underwent diagnostic audiological evaluation.Results: Among 8513 live births, we studied 96 newborns with first-degree parental consanguinity and 96 newborns without risk factors. We found a statistically significant difference (p = 0.007) between the groups, with a ‘refer’ screening result rate of 24% in the group with parental consanguinity and 9.4% in the group without risk factors. We diagnosed one case of sensorineural hearing loss and another of mixed hearing loss in the first group andnone of these cases in the second.Conclusion: Parental consanguinity was associated with a higher risk of a refer screening result in newborns, which suggests the need to consider this as a risk factor for childhood hearing loss.