bluuebunny/crossref_metadata_2025 huggingface dataset:
Factors Affecting the Successful Implementation of E-Government on Network Documentation and Legal Information Website in Riau
Authors: Wibowo Muhammad Ikhsan , Santoso Albertus Joko , Setyohadi Djoko Budiyanto
Published: February 2019

Network documentation and legal information website is a form of e-government applications such as Jaringan Dokumentasi dan Informasi Hukum (JDIH). JDIH website must be designed to be an effective and efficient information system. This study aims to determine the success factors of the implementation of JDIH website. The DeLone and McLean model and the Unified Theory Acceptance and Use of Technology (UTAUT) are the models used in this study. The case study is conducted in the Riau legal and human rights office. Data are obtained through questionnaires from 252 respondents in the Riau provincial government and some communities. The analysis uses Structural Equation Modeling (SEM) and Analysis of Moment Structure (AMOS). The results of this study show that nine hypotheses have positive effects. Meanwhile, four hypotheses have no positive effects on the success and use of JDIH website. The findings of this research will be used as a reference inthe development of JDIH website in the future.
Development of Word Game Algorithm for Learning Javanese Script
Authors: Suria Ozzi
Published: February 2019

The students consider learning Javanese script to be difficult particularly in distinguishing and memorizing Carakan, and memorizing Sandangan and Pasangan with its writing rules. This work intends to develop a supporting medium for learning Javanese script. The development process is started by defining the game functionalities by using the use-case diagrams, and then, the activity diagram is created to describe the workflow of the game algorithm. The database to support the game is also created and displayed by using the physical data model. Afterward, the game algorithm script is created using JavaScript so that the game can be played through a web browser. There are 27 respondents requested to test the game and to fill in questionnaires about the web application. The results suggest that 100%of respondents agree that the web application is necessary and useful to learn Javanese script. The application provides positive benefit to the users such as students who still need to learn Javanese script in schools with 97% average success rate to run the game
Gamification for the Ancient Kingdom of Nusantara with User-Centered Design Approach
Authors: Arifin Yulyani , Martin Martin , Ryan Ryan , Dratama Ryan
Published: February 2019

The purpose of this research was to conserve the history of Nusantara kingdoms with the interesting way for the students. The researchers proposed a method by combining the history of ancient kingdoms in Nusantara with the game. It was done by using gamification with the user-centered design approach. The data collection used questionnaires and literature review. Moreover, the researchers identified the resources by applying the gamification element, developing the game based on user requirement, and evaluating the usability testing. The result shows that the implemented gamification in learning Nusantara can attract the students to learn about history. Based on the result of usability testing that has already been tested using the prototype, it proves that the user interest to learn the history of the ancient kingdom in Nusantara is increased. The results also imply that gamification indeed is one of a suitable method to be used as a medium for students to learn about history, especially the ancient kingdoms in Indonesia.
The Development of E-Procurement System for an IT Consultant Company
Authors: Ang Ong Alexander , Sundjaja Arta Moro
Published: February 2019

The research objective was to identify, analyze, and design a procurement information system that was developed by an IT consultant company for their client companies. Data collection techniques used were literature study, field study, document study, learning and trying the existing e-procurement system. Then, it was followed by analysis on general procurement processes using objectoriented analysis with Unified Modeling Language (UML) as tools. The result is a web-based e-procurement application that supports documentation and storage of transaction data. It also generates reports in accordance with company requirements. The main system features are Request Usage Form (RUF), Purchase Request (PR), Purchase Request Summary (PRS), Request for Quotation (RFQ), Quotation, Winner Selection (WS), Purchase Order (PO), and Receive Report (RR). It can be concluded that the developed system can support procurement processes effectively and efficiently, and integrate the inventory and approval system. Integration with inventory system will result in easier stock checking and automated update of goods data in the inventory system. It includes creating item, editing item, and receiving made report document. Integration with approval system will also result in the simpler process of documents approval in the e-procurement system.
E-Commerce Feasibility Analysis and Strategic Planning to Develop a Small-Medium Enterprise Project in Banking Company
Authors: Veronica Veronica
Published: February 2019

The research aimed to identify the problem and the need to develop a small-medium enterprise project in a banking company. The analysis used a literature study, interviews, and observations. The results of the analysis supported the problem and were manifested in the development of information systems in the form of a recommendation for an e-commerce web design. The method consisted of data collection, data analysis and depth interview with Head of E-Commerce Department and Head of Marketing Communication in two days. The result shows that the banking company already uses Bukalapak to enhance their sales and brand. However, based on research, Facebook and Twitter also can be an option to enhance clients’ market access.
Islamic Educational Management for Seventh Grade Students at SMPN 1 Wonosegoro
Authors: Wibowo Arif Budi , Utomo Budi
Published: February 2019

This research explored the application of Islamic educational management for 7th graders at SMPN 1 Wonosegoro. The case study used interview, observation, and documentation to collect data which later were analyzed qualitatively. This school was chosen as the research setting because despite being a non-Islamic institution where religious and moral cultures were not commonly incorporated in the curriculum and school activities, it had several exceptional religious programs. It is found that their Islamic educational management is concerned to three major sub-areas namely; student orientation, curriculum, and extracurricular activities. These programs have been reviewed to have given significant impacts on their moral, social, and religious values proven with the very low number of student delinquency and a very good record of prayer habits among students.
Analysis of Student Attitudes to Develop a Self-Assessment Model of Genre-Based Writing Class
Authors: Taufiqulloh Taufiqulloh , Yuvita Yuvita , Sulistianingsih Endang
Published: February 2019

This research aimed to develop learners’ autonomy in English as Foreign Language (EFL) writing class, in particular, it was applying self-assessment. It enabled learners to raise their awareness in learning and to improve the goal orientation. The research also helped teachers to reduce their burdens of assessment and entailed a long-term effect on the learner’s autonomy. The objective of this research was to figure out student attitudes in developing a self-assessment model of genre-based writing class. Quantitative and qualitative analysis were utilized to draw the findings of this research. It was conducted at the English Education Department, Faculty of Teacher Training, Pancasakti University in the even semester of the academic year 2016/2017. The data were collected from a questionnaire, classroom observation, and focus group discussions. The results of this research present students’ problems, perceptions, and needs toward the teaching and learning process of genre-based writing classes attended as preliminary research to develop a self-assessment model of EFL writing.
Beyond Translation: Clarity, Sensitivity, and Artistry in Benedict Anderson’s Reading of Indonesian Literature
Authors: Dewi Novita
Published: February 2019

This research was to reconfirm Anderson’s theory (and praxis) of translation, i.e., transfer of language and culture from one to another with clarity, sensitivity, and high artistry. The analytical method used the application of diverse translation strategies to achieve pragmatic equivalence, i.e., the use of footnotes and foreignization-domestication principles. To consolidate the discussion, this research examined closely Anderson’s English translation of part of Titie Said’s “Bidadari” in his analysis of the novel and his translation of Pramoedya Ananta Toer’s short story “Nyonya Dokter Hewan Suharko”. The results indicate that what appears in his translation work is a broad range of discourses that help expound foreign-language (in this case English) intelligibility from the translating (Indonesian) one. His treatment of domesticating and the foreignizing translation is critically done owing to his gift of interests, passion, and persistence in the subject.
Effect of Computer Mediated Communication and Face-to-Face Communication on the Students’ Writing
Authors: Vendityaningtyas Vita , Styati Erlik Widiyani
Published: February 2019

This research aimed to investigate the effect of computer-mediated communication (CMC) and face-to-face (F2F) communication on the students’ writing. The subjects were the English department students of the fourth semester at the private University in Madiun. The researchers employed the students in class A and B as the research subjects. The research method used was a quasi-experimental design. The research design was divided into pre-test, treatment, and post-test. Both of the two groups were given pre-test to see the homogeneity of the two groups. The experimental group was given CMC, and the comparison group was given F2F communication. Then, both of the two groups were given post-test. The data collection technique was done by giving the students a writing test. Data analysis was done by employing the independent t-test. The result shows that the students’ writing after employing F2F communication is more effective than students’ writing after employing CMC. The students like to share the ideas directly than they employ CMC because it is more complicated. In addition, it is because the students find difficulty in sharing the ideas through CMC, so, F2F communication is better than CMC on the students’ writing quality.
Exploring the International Students’ Perceptions of the Indonesian Teaching Materials to Enhance Their Willingness to Communicate
Authors: Aguskin Lewinna Christiani , Maryani Maryani
Published: February 2019

This research had been conducted to investigate Indonesian teaching materials which corresponded with the Willingness to Communicate (WTC) in Indonesian to facilitate students’ learning. Therefore, this case study was conducted in Indonesian Language for Foreigners (BIPA) classes at a private university in Bandung, Indonesia. The objectives of the research were; to investigate BIPA students’ perceptions of the current language learning materials used; to discover to what extent the international students’ WTC was influenced by the current language material; and to explore the BIPA teachers’ strategies in developing language materials that facilitate the students’ WTC inside and outside the classroom. Semi-structured-interviews with seven BIPA students and four teachers and classroom recordings were used to collect data. Thematic analysis and descriptive statistics were used in data analysis. The findings show that the listening activities and interview assignments implemented in the current language materials, also the teachers’ strategies in class, such as using authentic materials and social media have positively impacted the students’ WTC. The findings of this research contribute to the classroom practice and material development of Indonesian to facilitate students’ learning and increase students’ WTC in Indonesian.
Analyzing Humor in Newspaper Comic Strips Using Verbal-Visual Analysis
Authors: Fallianda Fallianda , Astiti Rani Yuni , Hanim Zulvy Alivia
Published: February 2019

The researchers aimed at analyzing the meaning of humor in newspaper comic strips within a variety of incongruous combinations of multimodal rhetoric. The current research focused on how humor was produced via verbal medium only, via both verbal and visual media, as well as via visual only. The source of data was 74 political comic strips featured in Kompas newspaper. The General Theory of Verbal Humor (GTVH) was adapted as a framework of analysis. The analysis of the data confirms the following categorization: 49 humors appear only in text, 22 humor result from the interaction of text and image, and three humor come from images. In addition, humor which appears in text only and cases of the interaction between the two semiotic modes (either complementary or contradictory) is based on puns, exaggerations, contradictions, analogies, parallelisms, or verbal metaphors. Special attention is given to humor produced by the interaction of both text and image and by the images only which cause the hyperdetermination of humor, which can produce two or more humorous utterances. Meanwhile, the humor appeared in visual comic strips is produced exclusively by the visual language of knowledge resources.
Red and NIR Light-Responsive Polymeric Nanocarriers for On-Demand Drug Delivery
Authors: He Xinyu , Yang Xianzhu , Li Dongdong , Cao Ziyang
Published: February 2019

Red and NIR light-responsive polymeric nanocarriers capable of on-demand drug delivery
have gained tremendous attention for their great potential in cancer therapy. Various strategies have
been applied to fabricate such nanocarriers, and they have demonstrated significant therapeutic efficacy
and minimal toxicity to normal tissues. Here, we will review the current developments in various
red and NIR light-responsive polymeric nanocarriers with respect to their use in on-demand drug
delivery, including facilitation of drug internalization and boosting of drug release at targeted sites.
We summarize their components and design strategies, and highlight the mechanisms by which the
photoactivatable variations enhance drug uptake and drug release. We attempt to provide new insights
into the fabrication of red and NIR light-responsive polymeric nanocarriers for on-demand
drug delivery.
Oxidative Stress and Cancer
Authors: Klaunig James E.
Published: February 2019

Background:

Cancer is considered a major cause of death worldwide. The etiology of cancer is linked
to environmental and genetic inheritance causes. Approximately 90 percent of all human cancers have an environmental
cause (non-genetic inheritance) predominantly through lifestyle choices (smoking, diet, UV radiation)
while the remaining due to infections and chemical exposure. Cancer is a multistage process that involves mutational
changes and uncontrolled cell proliferation. Research has firmly established a causal and contributory role
of oxidative stress and oxidative damage in cancer initiation and progression.

Methods:

The purpose of this article is to review the role that oxidative stress and reactive oxygen species play in
the development of cancer. Both endogenous and exogenous sources of reactive oxygen species result in increased
oxidative stress in the cell. Excess reactive oxygen fumed can result in damage to and modification of
cellular macromolecules most importantly genomic DNA that can produce mutations. In addition, oxidative stress
modulates gene expression of downstream targets involved in DNA repair, cell proliferation and antioxidants. The
modulation of gene expression by oxidative stress occurs in part through activation or inhibition of transcription
factors and second messengers. The role of single nuclear polymorphism for oxidative DNA repair and enzymatic
antioxidants is important in determining the potential human cancer risk.

Conclusion:

oxidative stress and the resulting oxidative damage are important contributors to the formation and
progression of cancer.
Antiretroviral Therapy-associated Adverse Drug Reactions and their Effects on Virologic Failure- A Retrospective Cohort Study in Nigeria
Authors: Abah Isaac O. , Ncube Nondumiso B.Q. , Bradley Hazel A. , AgbaJi Oche O. , Kanki Phyllis
Published: February 2019

Background:

Adverse drug reactions (ADRs) associated with antiretroviral therapy (ART) can rapidly reverse the gains of ART resulting in poor health outcomes. We need an improved understanding of specific ART-related ADRs that influence virologic outcomes.

Objective:

To investigate the frequency of clinical ADRs and assess their effect on virologic failure in patients on ART.

Method:

We described the prevalence of major clinical ADRs, and the association between specific ADRs and virologic failure in a clinic cohort of HIV-1 infected Nigerians aged ≥18 years, on firstline ART between June 2004 and February 2012. Multivariable logistic regression was run to identify predictors of virologic failure at 24 and 72 weeks of ART.

Results:

Data of 12,115 patients with a median age of 34 (interquartile range: 29-41) years, and predominantly females (67%) were evaluated. Overall, 957 (7.9%) patients experienced at least one ADR during a median follow-up period of 4 years (interquartile range: 1-7). The three most prevalent ADRs were lipodystrophy (2.6%), anemia (1.9%), and skin rash (0.7%). Virologic failure rate was 36% and 34% at 24 and 72 weeks of ART, respectively. Anemia independently predicted the odds of virologic failure at 72 weeks of ART (adjusted odds ratio, 1.74; 95% CI: 1.2-2.51); adjusted for sex, age, pre-treatment CD4+ cell count, antiretroviral regimen, and medication refill adherence.

Conclusion:

Antiretroviral therapy-associated anemia increases the likelihood of late virologic failure. We recommend routine monitoring of hemoglobin levels and prompt management of anemia in all patients on ART as a strategy to improve virologic success rates.
In Silico Inhibition of BACE-1 by Selective Phytochemicals as Novel Potential Inhibitors: Molecular Docking and DFT Studies
Authors: Arif Nadia , Subhani Andleeb , Hussain Waqar , Rasool Nouman
Published: February 2019

Background:

Alzheimer’s Disease (AD) has become the most common age-dependent disease of dementia. The trademark pathologies of AD are the presence of amyloid aggregates in neurofibrils. Recently phytochemicals being considered as potential inhibitors against various neurodegenerative, antifungal, antibacterial and antiviral diseases in human beings.

Objective:

This study targets the inhibition of BACE-1 by phytochemicals using in silico drug discovery analysis.

Methods:

A total of 3150 phytochemicals were collected from almost 25 different plants through literature assessment. The ADMET studies, molecular docking and density functional theory (DFT) based analysis were performed to analyze the potential inhibitory properties of these phytochemicals.

Results:

The ADMET and docking results exposed seven compounds that have high potential as an inhibitory agent against BACE-1 and show binding affinity >8.0 kcal/mol against BACE-1. They show binding affinity greater than those of various previously reported inhibitors of BACE-1. Furthermore, DFT based analysis has shown high reactivity for these seven phytochemicals in the binding pocket of BACE- 1, based on ELUMO, EHOMO and Kohn-Sham energy gap. All seven phytochemicals were testified (as compared to experimental ones) as novel inhibitors against BACE-1.

Conclusion:

Out of seven phytochemicals, four were obtained from plant Glycyrrhiza glabra i.e. Shinflavanone, Glabrolide, Glabrol and PrenyllicoflavoneA, one from Huperzia serrate i.e. Macleanine, one from Uncaria rhynchophylla i.e. 3a-dihydro-cadambine and another one was from VolvalerelactoneB from plant Valeriana-officinalis. It is concluded that these phytochemicals are suitable candidates for drug/inhibitor against BACE-1, and can be administered to humans after experimental validation through in vitro and in vivo trials.
Synthesis and Antimicrobial Evaluation of 2-(Substituted-phenyl)-3-(4-(4- Nitrophenyl)Thiazol-2-yl)Thiazolidin-4-One Derivatives
Authors: Kumar Rakesh , Patil Shailendra
Published: February 2019

Background:

Diseases caused by microbial infections are very common worldwide. Although the search of innovative antimicrobial agents is the current focus for the researchers, the treatment of infectious diseases remains an important public health issue and a challenging problem in front of medicinal chemist.

Methods:

A series of 2-(4-hydroxyphenyl)-3-(4-(4-nitrophenyl) thiazol-2-yl)thiazolidin-4-one derivatives (T1-T10) was designed and synthesized. All the titled compounds were evaluated for their antimicrobial potential. Antimicrobial activity was performed by tube dilution methods against Gram negative Escherichia coli MTCC 443 (E. Coli), Gram positive bacteria: Staphylococcus aureus MTCC 3160 (S. aureus) and Bacillus subtilis MTCC 441 (B. Subtilis), and fungal strains: Aspergillus niger MTCC 281 (A. niger) and Candida albicans MTCC 227 (C. albicans).

Results:

Among the synthesized derivatives, compounds 2, 4 and 10 were found to be most active antimicrobial agents.

Conclusion:

In conclusion, a series of 2-(phenyl)-3-(4-(phenyl)thiazol-2-yl)thiazolidin-4-ones have been designed and synthesized. All the titled compounds were evaluated for their in vitro antimicrobial activity against five representative microorganisms. The results of antimicrobial study indicated that the presence of nitro and chloro groups in aromatic ring improved antibacterial activity, whereas the presence of hydroxy group improved antifungal activity of substituted 4-thiazolidinone derivatives.
Design, Synthesis and Biological Evaluation of Carbazole Derivatives as Antitubercular and Antibacterial Agents
Authors: Sellamuthu Satheeshkumar , Bhat Mohammad F. , Kumar Ashok , Nath Gopal , Singh Sushil K.
Published: February 2019

Background:

The neuroleptic chlorpromazine has been reported for antitubercular activity but the associated antipsychotic activity restricted its clinical presentation.

Objectives:

Novel derivatives of carbazole having structural similarity with chlorpromazine were designed, in an attempt to reduce the associated side effects, while retaining the antitubercular activity.

Materials and Methods:

The designed molecules were synthesized and screened for antitubercular and antibacterial activities. The blood-brain barrier (BBB) permeability and mammalian cell (VERO) cytotoxicity (CC50) were examined to determine the safety of compounds.

Results:

Among the developed compounds, 14c, 15c, 16c and 17c were found to be promising against Mtb H37Rv at MIC of 1.56 µg/ml. They were also effective against S. aureus and E. coli at MIC of 0.98 and 7.81 µg/ml, respectively. The BBB permeability of the compounds was found to be less than chlorpromazine. Therefore, the developed compounds are expected to have diminished antipsychotic effect. The compounds were further marked safe against mammalian VERO cells at CC50 > 90 µg/ml.

Conclusion:

The profound antitubercular activity with a concomitant reduction in BBB permeability of carbazole derivatives can pave new vista in the discovery of antitubercular drugs.
Deltametropool: Droom of belangengroep? Stadshavens passen niet in stedelijk veld
Authors: Brand Anton
Published: February 2019

De 'alliantie Deltametropool' beoogt haar visie op de ruimtelijke ontwikkeling van West-Nederland in te brengen in de discussie over de Vijfde Nota Ruimtelijke Ordening. Het gaat hier om een verzameling ideeën en studies, die zonder meer een interessante bijdrage leveren aan die discussie. Dat neemt niet weg dat de publicaties aanleiding geven tot kritiek. In dit artikel worden drie vragen beantwoord: wat is de Deltametropool, van welk stadsbegrip wordt uitgegaan en wie wil een metropool?
Haagse cultuurkritiek op het postmoderne stadslandschap: Anachronistische architectuur wordt bestraft met de prix de p... 1999
Authors: Kromhout Steven
Published: February 2019

Sinds 1991 wordt in het Theater Zeebelt in Den Haag jaarlijks een architectuurprijs uitgereikt. Bijzonder is dat de prijs niet gaat naar het mooiste staaltje architectuur, maar naar het slechtste project dat het voorgaande jaar in de hofstad het licht heeft gezien. De winnaar krijgt een gouden 'paardenlul', een vakterm voor een in de lengte doorkliefde baksteen. De jury voor 1999 heeft op vier februari bekend gemaakt dat de laatste Prix de P... van de twintigste eeuw naar architect Cornelis van der Ven gaat voor zijn bijdrage aan de nieuwbouwwijk Ockenrode.
Op zoek naar de inhoud van de Vijfde Nota: VIJNO-Congres roept meer vragen op dan dat het antwoorden biedt
Authors: Bontje Marco
Published: February 2019

De publicatie van de Vijfde Nota Ruimtelijke Ordening is inmiddels uitgesteld naar het najaar van 2000. Wellicht een indicatie dat men er in Den Haag nog altijd niet helemaaluit is hoe de ruimte inNederland in grote lijneningericht moet worden. Eenrecent symposium in Nijmegengaf een goede indruk van de'state of the art' van plannendNederlan~maarriepuiteindelijk meer vragen op dan het antwoorden bood.
Herrie bij een herstart: Vliegveld Laarbuch zorgt voor grensoverschrijdend planningsprobleem
Authors: Blüm Jan Jaap
Published: February 2019

Een Duits stadje dat in een spookstad dreigt te veranderen, Nederlanders die bang zijn voor geluidsoverlast en een verlaten strook beton van vijfendertig bij drieduizend meter: een relaas over het herbestemmen van een militair vliegveld.
Predictors of Success Using a mHealth Intervention in Adults with Prediabetes: Results of a Pilot Study (Preprint)
Authors: Mathioudakis Nestoras , Everett Estelle , Al-Hajri Noora , Abusamaan Mohammed , Lee Clare , Kane Brian , Dobs Adrian
Published: February 2019

BACKGROUND

About one-third of American adults have prediabetes and are at increased risk of type 2 diabetes. Mobile health (mHealth) technologies provide a scalable approach to diabetes prevention by encouraging physical activity (PA), weight loss, and adherence to a healthy diet in large numbers of patients.

OBJECTIVE

To identify factors associated with improvements in PA and glycated hemoglobin (A1c) measures among prediabetic adults who received a mobile intervention program (smartphone app in combination with a digital body weight scale) in a previously completed pilot study.

METHODS

We conducted a post hoc analysis of a 3-month prospective, single-arm, observational study using the Sweetch™ mHealth intervention among adults with prediabetes. Change in A1C was calculated as the difference between the 3-month and baseline A1C measurements and was categorized as decrease vs. no decrease. PA was evaluated using the total minutes and metabolic equivalent of task (MET)-hours per week. Change in MET-hours/week was categorized as increase vs. no increase. Age, sex, race, education, employment status, area deprivation, smartphone usage attitudes, and PA stage of change were compared between groups by outcomes of change in A1C and change in MET-hour/week.

RESULTS

A total of 37 adults received the final Sweetch mobile intervention and were included in the analysis. 62% were female and 81% were white, with average age of 57 years. The median [IQR] baseline A1C was 6.0% [5.8, 6.2]. A1C measure at 3-month was decreased in 24 (65%) participants when compared to baseline A1C. There was an inverse association between average MET-hours per week and change in A1C. Among participants whose A1C decreased vs. did not decrease, the MET-hours per week in last 2 weeks of study was 18.7 (8.4) and 15.0 (7.1), respectively (P=0.19), and the change in MET-hours per week was 2.1 (7.1) and 4.1(6.1), respectively (P=0.41). There were otherwise no statistically significant differences in participant factors by A1C and PA outcomes.

CONCLUSIONS

In this small pilot study, Sweetch mHealth intervention achieved comparable A1C response prediabetic adults with different individual, sociodemographic and anthropometric characteristics.

CLINICALTRIAL

ClincialTrials.gov NCT02896010; https://clinicaltrials.gov/ct2/show/NCT02896010 (Archived by WebCite at http://www.webcitation.org/6xJYxrgse)
Pengaruh Jus Buah Dan Ekstrak Daun Srikaya Terhadap Kadar Asam Urat Dan Kolesterol Darah
Authors: Andriani Yuni , Andriani Nela , Fransiska Randika , Arifin Helmi
Published: February 2019

Pemanfaatan tanaman srikaya (Annona squamosa L) telah banyak dilakukan oleh masyarakat secara turun temurun. Tanaman srikaya secara tradisional digunakan untuk batu empedu, memperlancar pencernaan, anti sembelit, meningkatkan selera makan. hipertensi, asam urat dan kolesterol. Oleh karena itu dalam penelitian ini dilakukan studi tehadap pengaruh dari jus buah srikaya terhadap kadar asam urat dan pengaruh ekstrak daun srikaya terhadap kadar kolesterol. Pada penelitian ini hewan uji dibagi menjadi lima kelompok uji. Kelompok kontrol negatif, kontrol positif (menggunakan pembanding allupurinol dan simvastatin), kelompok beberapa dosis dari jus buah dan ekstrak daun srikaya. Sebelum penginduksian jus buah dan ekstrak daun srikaya hewan uji diberi makan purin tinggi selama 7 hari. Pengamatan pengaruh pemberian jus buah dan ekstrak daun srikaya dilakukan pada hari ke 0, 3, 5, 7 dan 14. Hasil pengamatan menunjukkan bahwa pengaruh pemberian jus buah srikaya menurunkan kadar asam urat darah selama waktu pengamatan dan pada konsentrasi 600 mg/Kg BB memberikan penurunan kadar asam urat yang sama dengan penuruan asam urat pada kelompok pembanding menggunakan allupurinol. Sedangkan pengaruh ekstrak etanol daun srikaya menurunkan kadar kolesterol secara signifikan (p = <0,05) pada hari ke 7 dan 14, dan penurunan kadar kolesterol darah pada hewan uji kelompok dosis 600 mg/ Kg BB menunjukkan penurunan kadar kolesterol lebih baik dari kelompok pembanding dengan menggunakan simvastatin 10 mg/Kg BB
Profil Metabolit Sekunder Ekstrak Daun Berenuk (Crescentia Cujete L.)Dan Uji Sitotoksik Dengan Metode Brine Shrimp Lethality Test
Authors: Arel Afdhil , Wardi Epi Supri , Oktaviani Yolanda
Published: February 2019

Tanaman berenuk (Crescentia cujete L.) merupakan salah satu tanaman yang tumbuh di Indonesia.Secara tradisional daun berenuk digunakan untuk mengobati luka baru dan menurunkan hipertensi.Tujuan penelitian ini adalah untuk mengetahui profil metabolit sekunder ekstrak daun berenuk dan uji sitotoksik terhadap larva udang Artemia salina Leach dengan metode brine shrimp lethality test. Uji skrining fitokimia menunjukkan ekstrak daun berenuk mengandung alkaloid, flavonoid, fenolik dan steroid. Dari hasil identifikasi dengan metode KLT terhadap ekstrak daun berenuk diduga adanya alkaloid dengan nilai Rf 0,82; flavonoid dengan nilai Rf 0,57; fenolik dengan nilai Rf 0,85 dan steroid dengan nilai Rf 0,55. Hasil identifikasi dengan spektrofotometer uv-visible diperoleh empat puncak dengan panjang gelombang 664 nm, 402 nm, 329 nm dan 213 nm. Hasil uji sitotoksik didapatkan nilai LC50 30,54 µg/ml yang berarti ekstrak daun berenuk aktif terhadap ”brine shrimps” dengan level toksisitas yaitu toksik
Code Compliance and Functionality of Low-Energy Automatic Doors at Universities
Authors: Bown Michael , Hutchings Mark D.
Published: February 2019

Facility managers at universities should be concerned about the safety of those using low-energy automatic doors in campus buildings, particularly disabled people. People in wheelchairs have increased risk of injury from automatic door malfunction due to their limited mobility. Beyond basic functionality – opening and closing automatically – these doors must also adhere to certain government standards which are measurable. Facility management departments that operate under staffing constraints might not have enough resources to regularly verify that their doors are functioning within the government standard – especially at universities with numerous doors. In such cases, facility managers often rely on reactive feedback (i.e., feedback from users) to know when a door needs attention. Generally, such reactive feedback provides information on whether the doors are functioning, not on whether they are meeting government standards. This study 1) determined whether low-energy automatic doors at universities in the Intermountain West were properly working and were code compliant; 2) developed a simple methodology for measuring code compliance of low-energy automatic doors (opening/closing times and forces) and determining the time needed for facility managers to perform the tests. The study showed that it does not require much effort to measure the “functionality”, meaning the doors open and close properly and are code compliant. This can reduce or eliminate the need for facility managers to rely on inconsistent reactive feedback. The researchers tested 800 doors at seven large universities in the Intermountain West and found that 37 percent of the doors tested were non-functional and/or non-code-compliant. About two minutes were required to test each door. This large number of non-functioning doors should motivate facility managers to proactively test low-energy automatic doors and develop preventive maintenance plans for them.
Pengaruh Model Pembelajaran Problem Based Learning pada Materi Hukum-Hukum Dasar Kimia terhadap Hasil Belajar Siswa Kelas X MAN 2 Model Palu
Authors: Lamalat Tri Sulistiyawati , Supriadi Supriadi , Nuryanti Siti
Published: February 2019

Research on the effect of the problem-based learning model in the basic laws of chemistry on student’s learning outcomes in class X MAN 2 Model Palu has been done. This study aimed to determine the effect of the application of the problem-based learning model in the basic laws of chemistry on student’s learning outcomes in class X MAN 2 Model Palu. The type of research was a quasi-experimental study non-randomized design with pretest-posttest control group design. The sample was conducted with a purposive sampling technique. The study sample was students in class X MIA 6 as an experimental group (n = 22) and students in class X MIA 3 as a control group (n = 22). The data testing of students' learning outcomes used a non-parametric statistical analysis, the analysis of Mann-Whitney U-Test. The research results indicated that the mean value of the experiment class was high compared to the control class, 22.61 >18.39. The statistical analysis obtained that sig. 2-tailed (0,032) ˂ 0.05 and Zcalculation (-2.149) ˂ Ztable (-1.96). The average value of the experiment class was 82.95 while the average value of the control class was 73.64. So it can be concluded that there is the effect of applying the problem-based learning model in the basic laws of chemistry on student’s learning outcomes.
Pemanfaatan Limbah Cangkang Kelapa Sawit (Elaeis guineensis) Sebagai Pengadsorbsi Minyak Jelantah
Authors: Ubaidah Nurcholis Al , Nuryanti Siti , Supriadi Supriadi
Published: February 2019

Improper of usage and storage of cooking oil can increase the water content on cooking oil. It can decrease of cooking oil quality and fried food that resulted from this cooking oil which then can cause health problems. This study aimed to determine of the waste cooking oil quality after it was adsorbed with charcoal from eggshell palm oil (Elaeis gunieensis). The quality was determined based on the free fatty acids, the peroxide value, and the water content of the waste cooking oil before and after adsorption. Determination of free fatty acids was used titration method while determination of water content was used gravimetric method. The result showed that the cooking oil quality contained 0.014% of free fatty acids, 1 meq.O2/kg of peroxide value, and 0.0003% of water content. The waste cooking oil quality without adsorption process was 0.042% of free fatty acids, 26 meq.O2/kg of peroxide value, and 0.0011% of water content. After adsorption process with 5, 10, 15, 20, and 25 gram of charcoal from eggshell palm oil into 100 mL of waste cooking oil, it was found that 15 gram of eggshell weight was the best adsorbent. In was condition, the free fatty acid was 0.0006%, the peroxide value was 2 meq.O2/kg, and the water content 0.0005%. It showed that the waste cooking oil quality become better after adding of charcoal of eggshell palm oil as the adsorbent.
Pengaruh Model Pembelajaran Kooperatif Tipe Teams Games Tournaments dan Tipe Scramble Terhadap Motivasi dan Hasil Belajar Siswa Kelas XI IPA pada Materi Larutan Asam-Basa di SMAN 1 Bunta
Authors: Latupeirisa Veronica Purnama Sari , Nuryanti Siti , Mustapa Kasmudin
Published: February 2019

This study aimed to determine the effect of cooperative learning model teams games tournaments and scramble towards the student's motivation and learning outcomes of class XI IPA on the material of acid-base solutions in SMAN 1 Bunta. This research was a pre-experimental with the static pretest-posttest group design. The samples used in the study were students XI IPA 2 (n=30) as a class experiment 1 and students XI IPA 3 (n=28) as an experiment 2. The results of data analysis, the average value of class experiment 1 () was 78.2 and the experimental class 2 () was 73.21. Results of hypotheses testing by statistical t-test two parties it was obtained -ttable ≤tcal≥ + ttable  (tcal = 36.72 for class experiment 1; tcal = 24.65 for class experiment 2  and ttable = 1.67) with a significance level a = 0.05 and degrees of freedom 56, then H0 was rejected and Ha was accepted. The results of the students learning motivation questionnaire showed that the experimental class 1 was the attitude of "strong agree" with the positive category 85.12% and the experimental class 2 was in the attitude of "agree" with the positive category 84.17%. It can be concluded that there is an influence of cooperative learning model teams games tournaments and scramble to the student's motivation and learning outcomes of class XI IPA on the material of acid-base solutions in SMAN 1 Bunta.
Analisis Kadar Vitamin C, Kalsium dan Posforus pada Cabai Rawit (Capsicum frustescens L.) Hasil Pengawetan
Authors: Nurjannah Ida , Sabang Sri Mulyani , Afadil Afadil
Published: February 2019

This study aimed to determine the levels of vitamin C, calcium and phosphorus of the preserved chili pepper. In this research, two preservation techniques were applied, cooling and drying. For analysis of vitamin C was used the iodometric method, the results obtained in the technique of cooling was 11.08 mg/100 g and the drying technique was 9.85 mg/100g. For calcium and phosphorus analysis was analyzed by using the spectrodirect instrument, research result obtained for calcium in the cooling technique was 20.00 mg/L and the drying technique was 12.33 mg/L while for phosphorus of the cooling technique was 27.66 mg/L and the drying technique was 55.16 mg/L.
Pengaruh Konsentrasi Surfaktan Campuran (Span 80 dan Span 20) dan Rasio Volume Emulsi/Fasa Eksternal terhadap Ekstraksi Ion Kadmium (Cd) Menggunakan Teknik Emulsi Membran Cair
Authors: Amin Alif Hidayatullah , Hamzah Baharuddin , Ningsih Purnama
Published: February 2019

Research on the extraction of cadmium(II) ion has been performed using the emulsion liquid membrane technique. This research used laboratory experimental method using benzoyl acetone as a carrier, kerosene as a membrane, nitric acid solution as an internal phase, span 80 and span 20 as a surfactant, and cadmium(II) solution as a sample. The present study was conducted to determine the optimum conditions of cadmium(II) ion extraction in solutions comprising variations in surfactant concentration of spans 80 and span 20 mixtures (1.5–3.5%) and variations in the ratio of emulsion/external phase (1:5–1:7). Determination of remaining of cadmium(II) ion concentration in the sample was analyzed using UV-Vis spectrophotometer at 519 nm wavelength. The results showed that the concentration of mixed surfactants (span 80 and span 20) which resulted in a maximum percent of extraction was 2.5% with 60.11% extraction percentage. In addition, the volume ratio of the emulsion/external phase gave a maximum extraction percentage at a ratio of 1:5.5 with an extraction percent of 78.03%.
Melatonin Increases Brown Adipose Tissue Volume and Activity in Patients With Melatonin Deficiency: A Proof-of-Concept Study
Authors: Halpern Bruno , Mancini Marcio C. , Bueno Clarissa , Barcelos Isabella P. , de Melo Maria Edna , Lima Marcos S. , Carneiro Camila G. , Sapienza Marcelo T. , Buchpiguel Carlos Alberto , do Amaral Fernanda Gaspar , Cipolla-Neto José
Published: February 2019

Melatonin, a pineal hormone synthesized at night, is critical for the synchronization of circadian and seasonal rhythms, being a key regulator of energy metabolism in many animal species. Although studies in humans are lacking, several reports, mainly on hibernating animals, demonstrated that melatonin supplementation and a short photoperiod increase brown adipose tissue (BAT) mass. The present proof-of-concept study is the first, to our knowledge, to evaluate BAT in patients with melatonin deficiency (radiotherapy or surgical removal of pineal gland) before and after daily melatonin (3 mg) replacement for 3 months. All four studied patients presented increased BAT volume and activity measured by positron emission tomography-MRI. We also found an improvement in total cholesterol and triglyceride blood levels without significant effects on body weight, liver fat, and HDL and LDL levels. Albeit not statistically significant, fasting insulin levels and HOMA of insulin resistance decreased in all four patients. The present results show that oral melatonin replacement increases BAT volume and activity and improves blood lipid levels in patients with melatonin deficiency, suggesting that melatonin is a possible BAT activator. Future studies are warranted because hypomelatoninemia is usually present in aging and appears as a result of light-at-night exposure and/or the use of β-blocker drugs.
MULTIVARIATE ANALYSIS OF MORPHOLOGICAL TRAITS IN YAM BEAN Pachyrhizus erosus
Authors: Karuniawan Agung
Published: February 2019

The objective of this study was to estimate the genetic diversity among yam bean landraces collected from different islands of Indonesia based on morphological traits. Thirty-six selected yam beans accessions from diverse ecological regions of Indonesia and six accessions from South and Central America were examined. Field trials were performed at two locations in Bogor, Indonesia, in a randomized block design with two replications. Genetic diversity between accessions based on morphological traits was determined by multivariate analysis. Time to flowering, first pod development, leaf length, leaf width, and internodes length played essential role in classification of the yam beans. A clear separation among the yam bean accessions collected from Indonesia, i.e., Sumatra landraces and the landraces collected from eastern Indonesia was detected. Furthermore, American accessions are not obviously separated from Indonesian yam bean materials.
COLOR POLYMORPHISMS ON COMMON CARP CULTURED IN INDONESIA
Authors: Gustiano Rudhy
Published: February 2019

In most cases, phenotypic variation is partly a result of genetic differences and partly environmental in origin. It appears that polymorphism is caused by some gene frequency changes which are due to natural selection. Morphological markers (body color and scale pattern) are the easiest indicators to identify and important when large sample are involved. In addition, the coloration in food fishes is often important in determining market price. Moreover, the production of fish depends not only on their genes and environment but also on the interaction of these two factors. Several investigations reported that some color genes have pleiotropic effect on growth rate and viability of fish. Hence, it is important to understand the basis of color polymorphisms in order toenhance genetic improvement and brood stock management plans for common carp in Indonesia. The occurrence color polymorphism showed that the proportion (%) of  each color morphs in each farm showed a high proportion of green color morph in common carp stocks. Dark colored carps are preferred over brightly pigmented ones. Bright colored morphs are preferred to the colorless (white). Comparison among the red, yellow, white, green and blue color morphs of common carp showed that each morph has its own specific chromatophore type densities, pigment distribution pattern. The study also showed that color variation is governed by the types of pigment cells present. The genetic color polymorphisms study showed that various color phenotypes were mainly controlled by simple Mendelian inheritance. Symbols for gene loci proposed as follow: B1 and B2 for common green body background (wild type allele), R1 and R2 for red and yellow. T is for wild nontransparent scale type and P for uniform body color background. B1 and B2 are epistatic to R1 and R2 genes. On the basis of the growth rate comparison results obtained on common carp in Indonesia, there was evidence that dark color (green and blue) common carp gained weight faster than the light color one (red). Green and blue colored showed similarity in growth performance.
Stabilitas Produksi Sepuluh Genotip Padi Sawah di Lahan Salin
Authors: Intan , , Riyanto Agus , Farid Noor , Suprayogi , , H. Totok Agung D.
Published: February 2019

Diversity of the physical environment which is followed by the diversity of genetic resources in agriculture in Indonesia is very wide. The potential of specific environments can be used by breeders in determining the applicability distribution of a superior new cultivars, such as releasing the rice cultivars tolerant salinity with high yield potential for a wide range of spatial and specific. We growed 10 genotypes of rice and Siak Raya as check in three locations with low to moderate levels of salinity, Kebumen (140 µc/cm-350 µc/cm), Batang (861 µc/cm-5783 µc/cm), dan Pekalongan (670 µc/cm-1416 µc/cm). Genotypes showed difference performance, which indicated diversity of agronomic characters at three location. Genotypes stability were tested refer to Eberhart and Russell (1963), UNSOED 8 is a stable genotype with higher gran yield than the total average of genotypes.
Tolerance Evaluation to Aluminium Stress of Several Soybean Pure Lines
Authors: Sunarto ,
Published: February 2019

An Experiment was conducted to evaluate tolerancy to aluminium toxicity of several soybean pure lines generated from Dempo x wills on two levels of Al-Saturation of Red Yellow Podzolic soil. The experiment was arranged in a split plot design based on a randomized complete block design. The main plots were Al-saturation and the sub-plot were cultivars and pure lines. The result showed that T33, R22, and S4 were very tolerant to acid soil and Al-saturation.