bluuebunny/crossref_metadata_2025 huggingface dataset:
A CASE OF MISPLACEMENT OF CU-IUCD INTO BLADDER PRESENTED WITH SECONDARY VESICAL CALCULUS
Authors: Shah Shyamal , Periasamy P.
Published: November 2024

Intravesical migration of cu-iucd is an uncommon but serious complication of intrauterine contraceptive
device. Calculus formation is common over such migrated/misplaced intrauterine contraceptive
devices.This dreaded complication usually presents with lower urinary tract symptoms such as supra pubic pain, frequency, and
nocturia.We present a case of a 55-year-old woman with intravesical migration of copper-T device placed in the immediate
postpartum period 30 years ago. She presented with dysuria, usg revealed vesical calculus and ct revealed cu iucd in pelvic
area with vesical calculus.The misplaced device was encrusted with a 1.8cm-sized stone near base of bladder. Surprisingly, the
patient never had symptoms and hence she never followed up for 30 years. The copperiucd could not be removed
endoscopically, and therefore an open vesicolithotomy was performed. This case has been presented to highlight the
signicance of following up patients with intrauterine contraceptive device to avoid potentially devastating complications.
VULVAL ANGIOMYXOMA : A CASE REPORT
Authors: Ankita Kumari , Palve Tushar , Fatemi Sakina , Thatikond Rajashree , Somaiya Hetvi
Published: November 2024

Vulvar diseases make up only a small portion of cases seen in
gynecological practice, with benign tumors comprising 22% of
1
all vulvar conditions . Angiomyxomas are rare benign, slowgrowing tumors that arise from mesenchymal cells and are
distinguished by a prominent myxoid matrix of connective
2
tissue and abundant blood vessels . There are two
phenotypes of angiomyxomas: supercial (also known as
3
cutaneous myxoma) and aggressive angiomyxoma .
“REVIEW OF COMMELINA BENGHALENSIS LINN.,(COMMELINACEAE) : FROM A PHYTOMORPHOLOGY , CHEMICAL AND TOXICITY STUDY OF INDIAN MEDICINAL HERB AS A PHARMACOLOGICAL APPROACH.”
Authors: P. Chavhan Meghana , G. Telrandhe Shraddha , P. Bawane Rajani , K. Makde Vrushali , G. Pangul Nakul , Jumade Prasad P. , S. Wanjari Dinesh
Published: November 2024

In the current healthcare system, herbal remedies are gaining prominence. It was the primary motivator
for improved care since the beginning of time. The annual herbaceous weed known as Bengal Dayower,
Commelina benghalensis Linn., is a member of the Commelinaceae family. Polyphenols, avonoids, tannins, and alkaloids are
the primary phytochemicals present in this plant. The plant's various parts have been linked to signicant therapeutic activities,
including antimicrobial, anti-cancer, anti-inammatory, anti-oxidant, anti-diarrheal, anthelmintic, fertility-inducing, antiviral,
anxiolytic, hepato-protective, anti-urolithiasis, analgesic, thrombolytic, sedative, and larvicidal qualities, according to a review
of the literature.This review study focuses on Commelina benghalensis's morphology, phytochemistry, pharmacology and
therapeutics activities and toxicity study. A general understanding of the plant under study may be obtained from this review
process.
ANALYSIS OF PLACENTA PREVIA AND MORBIDLY ADHERENT PLACENTA SPECTRUM SECTIONS AND THEIR FETO-MATERNAL OUTCOMES USING ROBSON CLASSIFICATION
Authors: F Lewis Preeti , Thathira Swati , Bendale Rucha , Surpatne Vaishnavi
Published: November 2024

Background: Placenta previa and placenta accreta syndrome is a high-risk obstetric problem with high
rates of feto-maternal mortality and morbidity. This study is aimed at determining the feto maternal
outcomes of mother who underwent cesarean section for PAS/ placenta previa and their feto-maternal outcomes. The use of the
patented Ashok Anand Stitch in these cases have been analyzed. Method: this is a prospective study conducted in a tertiary
care center for a period from April 2023 to March 2024. Results: The total number of deliveries in the present study were 1769
deliveries out of which 730 were cesarean section, of which total placenta previa and MAP were 56. The maximum number of
placenta previa and morbidly adherent placenta were seen in the previous 1 LSCS (32). Maximum babies were baby with
mother. The study shows the maximum NICU admission for low birth weight. Conclusions: The study shows that this tertiary care
center had lesser numbers of cesarean hysterectomies as compared to the others due to the use of ARA stitch. The need for blood
and blood products decreased as well due to the same.
A COMPARATIVE STUDY OF MIFEPRISTONE PLUS MISOPROSTOL VS MISOPROSTOL ALONE IN MID TRIMESTER TERMINATION OF PREGNANCY
Authors: Gurugunti Suman Umeshchandra , Amargol Swetha
Published: November 2024

Background: Medical methods of abortion are those induced by abortifacient pharmaceuticals. Medical
methods of abortion have become an alternative method of abortion with availability of prostaglandin
analogues and anti-progesterone mifepristone. The present comparative study is undertaken to analyse the efcacy of
mifepristone plus misoprostol vs misoprostol alone in mid-trimester termination of pregnancy. To kn Aims And Objectives: ow
induction abortion interval in both regimens and to study possible side effects of drugs and effective cost of both drug regimens.
Methods: The present study was undertaken in Department of OBG, at MRMC, Kalaburagi over a period of 18 months. The
study was conducted by dividing women approaching for mid trimester termination of pregnancy into two groups each
consisting of 30 women. After admission, women assigned to GROUP A was given mifepristone 200 mg orally.24hours after
administration of mifepristone, started with misoprostol 600mcg per vaginally followed by misoprostol 400mcg sublingually
every 3rd hourly until termination or maximum of 5 doses. women assigned to GROUP B were given misoprostol 600mcg
rd pervaginally followed by misoprostol 400 mcg sublingually every 3 hourly until termination or maximum of 5 doses. The
outcome were studied in terms of induction-abortion interval, expulsion time, total dose of misoprostol, side effects and cost
effectiveness of both regimens. The Mean induction abortion interval was 29.23 hours in GROUPA wher Results: eas 6.21hours
in GROUP B. Mean expulsion time was 6.19 hours GROUPA whereas 8.37hours GROUP B. It is statistically signicant with p
value of 0.014. Mean dose required in GROUP A was 1242.86 mcg which was less when compared to GROUP B,1613.33 mcg
with p value of 0.004. There was no statistically signicant difference between side effects in two groups. Mean cost for drugs in
(GROUP A) was 516.33 rupee and 158.67 rupee in misoprostol group (GROUP B). Conclusion: Pretreatment with mifepristone
resulted in shorter expulsion time and reduced dose misoprostol required compared with misoprostol only group.
MULTIPLE MYELOMA: A COMPREHENSIVE REVIEW OF CLINICAL FEATURE AND MANAGEMENT
Authors: Carvajal Angarita Luis Antonio
Published: November 2024

Multiple myeloma (MM) is a hematologic malignancy that accounts for 1-2% of all cancers and 17% of
hematologic malignancies worldwide. It predominantly affects older adults, with a higher incidence in
males and African American populations. Clinical manifestations often include bone pain, anemia, renal insufciency, and
hypercalcemia, due to the proliferation of malignant plasma cells. Diagnosis is based on clinical, laboratory, and imaging
ndings, including the detection of monoclonal proteins in serum or urine, and the presence of clonal plasma cells in bone
marrow biopsy. Imaging techniques such as MRI and PET/CT play a key role in identifying osteolytic lesions and assessing
disease progression. The management of MM has advanced with the use of autologous hematopoietic cell transplantation,
triple drug regimens, and maintenance therapies.
A STUDY OF FOOT MORPHOLOGY IN UNDERWEIGHT AND OVERWEIGHT ADOLESCENTS
Authors: Shah Ishita , Mohite Shraddha
Published: November 2024

Objective: The objective of the present study was to examine the impact that body mass index (BMI) has
on adolescent foot morphology between 12-16 years. The purpose of the study was to categorize foot
types (at, average and high arch) and rates of these foot types across underweight, normal weight, and overweight
participants. Method: A total of 76 adolescents, both male and female, from Satara, Maharashtra, were selected using a simple
random sampling technique. Participants who were underweight or overweight according to BMI underwent foot morphology
assessments using footprint analysis. Measurements taken included foot length, arch angle, and dorsal arch height. The study
design was analytical, and the duration was six months. Statistical analysis was used to evaluate the correlation between BMI
and foot morphology. Result: The study determined three distinct arch types: at, slender, and robust. Overweight adolescents
showed a higher prevalence of at feet, correlating with increased pressure on the medial longitudinal arch. In contrast,
normal-weight adolescents showed a shift towards robust and slender feet with increasing age. Underweight participants
exhibited growth-related foot issues due to malnourishment. Conclusion: BMI signicantly inuences foot morphology in
adolescents. Flat feet are more common in overweight adolescents due to excessive weight on the medial arch, whereas
underweight adolescents face growth-related complications in foot development. Early identication and intervention may
help alleviate potential health problems related to foot structure.
“FLOATING KNEE” - OUTCOMES IN THE MANAGEMENT OF IPSILATERAL FEMUR AND TIBIA FRACTURES
Authors: Garlapati Siva S , R Pondugula Venugopala , R Sane Manindhar , Koduru Satya K
Published: November 2024

Background: Floating knee injuries are more common with increasing road trafc accidents. Surgical
stabilization with early rehabilitation produces the best outcomes. The aim of the present study is to study
the clinical outcome and various challenges faced during the treatment of these injuries. Cases wer Methods: e selected based
on inclusion and exclusion criteria admitted to our hospital from June 2018 to October 2022. Data was collected regarding
clinical union, radiological union, and functional outcome and analysed using Microsoft Excel. In o Results: ur study, 64% of
patients returned to their pre-injury functional status with or without some modication in the work pattern, 12% of patients never
returned to their pre-injury functional status due to permanent disability. Early surgery with aggre Conclusion: ssive
physiotherapy even though results in more infections, and complications and needs a long hospital stay gives good overall
functional results.
THE IMPACT OF THE COVID-19 PANDEMIC ON THE QUALITY OF LIFE OF MBBS STUDENTS AT DECCAN COLLEGE OF MEDICAL SCIENCES, HYDERABAD, TELANGANA.
Authors: Shareef Fateen , Mohammed Abdul Wasay , Fatima Azha , Basith Abdul , Tabassum Azeeza
Published: November 2024

Background: COVID-19 has been recognized as an additional stressor for the general populace,
particularly for medical students. It has been established that medical students exhibit elevated levels of
psychological distress manifested through symptoms of depression, anxiety, and stress. This research aims to evaluate the
repercussions of the COVID-19 pandemic on the quality of life of MBBS students, with a specic focus on their experiences with
E-learning. Aim: The primary aim of this study was to examine the impact of the COVID-19 pandemic on the overall quality of
life of MBBS students, with a particular focus on their e-learning experiences. Methods: This is a cross-sectional survey,
executed with a sample size of 120 MBBS students amidst the second wave of the pandemic, at Deccan College of Medical
Sciences. The survey employed a questionnaire disseminated online (Google Forms) to the cohort of medical students. The
data were subjected to statistical analysis utilizing SPSS software. Results: The study involved 120 participants, with a higher
proportion of females (57.5%) than males (42.5%). The majority were aged 20 years (38.3%) and in their 1st or 2nd year of MBBS
(39.2% and 42.5%, respectively). Most participants rated their quality of life as good (70.8%) during the COVID-19 pandemic,
although 15.8% reported poor sleep quality. Regarding academic performance, 55.8% felt their study quality was good, but
40.8% disagreed that e-learning was sufcient for their education. Mobile phones were the most commonly used device for elearning (40%). Conclusions: The students identied a substantial interruption to their medical education, expressed an
aspiration to persist with in-person clinical rotations, and demonstrated a readiness to embrace the risk of contracting COVID19. They perceive a heightened sense of safety following their vaccination. Our innovative ndings furnish a robust basis to
inform the delineation of medical student responsibilities within the clinical setting amidst the ongoing pandemic and potential
future health crises.
AN ATYPICAL CASE OF COMPLEX ELBOW INJURY INVOLVING FRACTURE OF MEDIAL CONDYLE OF HUMERUS AND RADIAL HEAD
Authors: R Panickar Sidhardh , Choudhary B Mohan , Lourdes Kevin , Velmurugan Velmurugan , Ganesh Arjun
Published: November 2024

Complex elbow fracture dislocation involving fracture of Medial condyle of humerus and radial head of the ipsilateral
side is a rare pattern of injury. Very few reports have shown such a pattern of injury. We present such a case of a 33 yr old
lady with Complex elbow fracture dislocation with a Distal humerus- Milch fracture dislocation of medial condyle Type 2
or Kilfoyle Type 3 and Radial head-Masons Type 4 injury, treated with open reduction and internal fixation for the distal
humerus ,radial head replacement as well as lateral collateral ligament reconstruction using suture anchors. Post
operatively at 6 months patient has almost near normal range of movements with a good functional outcome score.
SUBTLE FACETS OF HYPERTHYROIDISM IN CHILDREN: EASY FATIGABILITY AND PALPITATION AS PRIMARY MANIFESTATIONS.
Authors: Israr Khan Diwan , Salam Sabeeh
Published: November 2024

Background: Thyroid hormone deficiencies or excesses are known to have a wide range of impacts on different organ
systems. According to the American Thyroid Association, hyperthyroidism is defined as subnormal (often undetectable)
serum thyrotropin (TSH) with high serum levels of free thyroxine (FT4). With over 95% of cases, Graves' disease is the
most frequent cause of hyperthyroidism, with Hashimoto's disease in children coming in second. Based on compelling
scientific data, hyperthyroidism is a rare but potentially dangerous childhood illness that, if left unchecked, can cause a
wide range of problems, including effects on development and growth. History, physical examination, and thyroid
function test are used to diagnose hyperthyroidism based on some study evidence and consensus. A 16- Case Report:
year-old male child presented with weakness and poor appetite along with palpitation. He was provisionally diagnosed
with Iron deficiency Anaemia. Haematopoietic medication was chosen as the initial treatment for Iron Deficiency
Anaemia. However, this treatment failed to normalize the patient symptoms. We further evaluated patient's thyroid
profile, his TSH was significantly reduced and T3 & T4 were elevated suggestive of diffuse toxic goitre. This Conclusion:
case report highlighted a rare case of hyperthyroidism in male child that may only manifest as easy fatiguability and
palpitations.
RELATIONSHIP BETWEEN INFERTILITY STIGMA AND FERTILITY QUALITY OF LIFE: EXAMINING PERCEIVED SOCIAL SUPPORT AS A MEDIATION
Authors: Lobo Deepika , Joshi Meenakshi , Sharma Jyotika , Udamale Ajinkya
Published: November 2024

Infertility is a common disorder that affects over 186 million individuals worldwide. The goal of this research is to
examine whether there is a relationship between infertility stigma and fertility quality of life among Indian women.In the
association between infertility stigma and fertility; quality of life, perceived social support is assessed as a mediator.
Participants who identified as currently or previously infertile discussed their feelings about fertility stigma,the quality
of their fertility-related social support,and their fertility quality of life (FQoL).Only 307 completed questionnaires were
obtained from the 334 identified individuals who were given data collection tools. Structural Equation Modeling was
used to treat the data (SEM).It was observed that infertility stigma and perceived social support had an impact on fertility
quality of life, either directly or indirectly. Fertility quality of life was reduced by stigma, and this relationship was
partially mediated by infertile women's perceptions of social support.Additionally,the stigma associated with Infertility
was adversely related with the overall quality of past fertility-related support.
STREPTOCOCCUS PNEUMONIAE SEPSIS LEADING TO ACUTE LIVER FAILURE AND HEPATIC ENCEPHALOPATHY IN A PEDIATRIC PATIENT: A RARE AND LIFE-THREATENING COMPLICATION
Authors: Amuthan Shwetha , Ravichandran Latha
Published: November 2024

Streptococcus pneumoniae is a common cause of respiratory and invasive infections in children but is rarely associated
with acute liver failure (ALF). This case report describes a pediatric patient who developed ALF and hepatic
encephalopathy secondary to S. pneumoniae sepsis, presenting significant diagnostic and management challenges.
This case underscores the importance of early recognition and aggressive management of S. pneumoniae sepsis
complicated by ARDS, acute liver failure and hepatic encephalopathy in a pediatric patient. S. pneumoniae can cause
severe multi-organ dysfunction and a multidisciplinary approach, including ventilation support, liver protective
strategies and ammonia reduction therapies was crucial for recovery. This report highlights the need for heightened
awareness of the potential for sepsis to precipitate liver failure in children,even in the absence of prior liver disease
A STUDY ON ONLINE SHOPPING BEHAVIOUR WITH SPECIAL REFERENCE TO ALAPPUZHA DISTRICT
Authors: S Mahima. , Gopalakrishanan Sreedevi , B Deepthi , A Alfiya
Published: November 2024

Online shopping is a recent phenomenon in the field of e-business. The rise in the number of households possessing
smart phones with high-speed internet access has led to widespread acceptance of e-commerce. The competition
among e-vendors is getting intensified year by year,and all of them are adopting innovative and creative approaches to
attract, satisfy, and retain customers. Accessibility and convenience are the key drivers for a major shift to online
shopping. Due to ever increasing work pressure, multiple roles in life style, paucity of time, etc., consumers are on the
lookout for such facilities that can suit their changing needs.The present study is an attempt to make an inquiry into the
factors that determine the online buying behavior and suggestions to improve the online shopping experience.
MICROBIAL PROFILE AND ANTIMICROBIAL RESISTANCE PATTERNS IN ACUTE OSTEO ARTICULAR INFECTION IN CHILDREN
Authors: Thangavel Ramya , Priya Swathi
Published: November 2024

Acute osteomyelitis and septic arthritis are critical infections in children,mainly caused by bacteria.Understanding the
epidemiology of these infections and the antimicrobial resistance patterns is essential for optimizing treatment. This
retrospective cross-sectional study aimed to describe the microbial profile and antimicrobial resistance in children with
acute osteoarticular infections hospitalized between January 2019 and April 2022.Among 78 children,21 had confirmed
microbiological diagnoses, with Staphylococcus species being the most common pathogen. Specifically, 11 out of 14
cases were Staphylococcus aureus, four of which were methicillin-resistant (MRSA). Notably, only 61% of the isolated
microorganisms were sensitive to cephalosporins, which are commonly used empirically for treatment. This study
highlights the evolving bacterial resistance and the need for tailored antibiotic regimens in pediatric osteoarticular
infections.
TO STUDY AWARENESS AND ATTITUDE ABOUT EYE DONATION AMONG PARAMEDICAL WORKERS
Authors: Kansagra Riddhi , Chaudhari Chaitali , Amin Nikunj , Garala Jeel
Published: November 2024

Aims: To study awareness and willingness for eye donation among paramedical workers.Materials and Methods: 64
paramedical workers were asked to answer questionnaire in their own language. Questions were asked regarding
assessment of knowledge,awareness and willingness for eye donation.Results: Study revealed 75% awareness rate for
eye donation after death and 64% responders knew that the ideal time for eye donation was within 6 hours of death.
Reasons for not pledging eye donation included unacceptable idea of separating eyes causing disfigurement of face
(18/64), lack of awareness about eye bank (18/64) and religious restrictions (11/64). However other aspects assessed
had much lower awareness rates; ideal part transplanted (52%),Age limiting not restricting donation
(67%),confidentiality of donor and recipient (54%),hospital having facility of eye bank (63%).48% of respondents were
willing to pledge for eye donation.Conclusion: Paramedical staffs of any hospital are backbone of health care system
and can play major role in motivating patients. Our study concluded that even though 75% of staff had knowledge,17%
believed it to be against religious beliefs and 28% believed it causes disfigurement of face. These beliefs are major
hurdle towards patient motivation for eye donation and efforts are required to ensure that knowledge is imparted to
health care workers.
ELECTRON MICROSCOPY OF PERIPHERAL BLOOD ERYTHROCYTES AS A PREDICTOR OF DETERMINING THE SEVERITY OF ACUTE PANCREATITIS
Authors:   University ", Gulikyan G.N. ,   Clinical hospital ",   Russian Railways-Medicine",   of the city of Krasnoyarsk",   , Russia, Pakhomova R.A. ,   Medical Institute of Continuing Education, Russian Biotechnological University (ROSBIOTECH), Moscow, Russia
Published: November 2024

Background. Acute pancreatitis is one of the five most common diseases in urgent abdominal surgery. Recently, the methods of electron microscopy of erythrocytes as a predictor of determining the severity of acute pancreatitis have become firmly established in practice. Purpose. To compare the state of erythrocytes of healthy people with erythrocytes of patients with acute pancreatitis of different severity. Materials and methods. The study of peripheral blood erythrocytes of healthy people and patients with pancreatitis of varying severity was carried out. For comparison, the erythrocyte shape, cytoplasm state, as well as the content of potassium, sodium, calcium, nitrogen and oxygen were studied. Results. During the study, the correlation between the severity of acute pancreatitis course and changes in the shape, membrane and ionic composition of the peripheral blood erythrocyte cytoplasm was noted. Conclusions. According to the obtained changes in erythrocytes, it is possible to indirectly judge the processes occurring in the cells of the pancreas and, accordingly, to determine the severity of the acute pancreatitis course.
FEED SMOOTHIE PRODUCTION FROM VEGETABLE AND FRUIT WASTE
Authors:   Russian Biotechnological University, Moscow, Russia, Dzhabakova A.E.
Published: November 2024

Background. Currently, about 50-60% of vegetable and fruit waste is generated at fruit and vegetable storage facilities, retail stores, distribution centers of retail chains from the total volume of discarded products. One of the solutions to reduce waste is to propose a way of their processing: fodder smoothie production. Purpose. To select technological processing modes for obtaining a sample mixture of fodder smoothie from vegetables and fruits. Materials and methods. For obtaining a model mixture of fodder smoothie 30% of tomatoes, 10% of potatoes and 20% each of carrots, cabbage, apples were used. To work out the technological parameters of obtaining the sample mixture, the following were recorded: grinding time, grinding speed, appearance of the obtained model mixture, as well as pH and mass fraction of soluble solids were determined.Results. The pH of the sample mixture of fodder smoothie was 6.4, the value of the mass fraction of soluble solids ranged from 14.2% to 16% depending on the parameters of producing the mixture. The sample mixture was mushy of brown color. Conclusion. The technological parameters were selected for the investigated sample mixture. The pH of the crushed product does not change with the change of technological parameters. Mass fraction of soluble solids increases with increasing the amount of product grinding time and the grinding speed.
A CLINICAL CASE OF THE “PELVIC FINGER”, A CONGENITAL ANOMALY OF THE OSTEOARTICULAR SYSTEM, DIAGNOSTIC METHODS
Authors:   Main Military Clinical Hospital of the National Guard Troops of the Russian Federation, Balashikha, Russia, Obel'chak I.S. ,   Medical Institute of Continuing Education, Russian Biotechnological University (ROSBIOTECH), Moscow, Russia, Frumen A.G. ,   Main Military Clinical Hospital of the National Guard Troops of the Russian Federation, Balashikha, Russia, Sedova S.V. ,   Main Military Clinical Hospital of the National Guard Troops of the Russian Federation, Balashikha, Russia, Shashkin K.M. ,   Main Military Clinical Hospital of the National Guard Troops of the Russian Federation, Balashikha, Russia,   Medical Institute of Continuing Education, Russian Biotechnological University (ROSBIOTECH), Moscow, Russia, Mamet'eva I.A. ,   Main Military Clinical Hospital of the National Guard Troops of the Russian Federation, Balashikha, Russia,   Medical Institute of Continuing Education, Russian Biotechnological University (ROSBIOTECH), Moscow, Russia
Published: November 2024

The variants of congenital anomalies of the pelvic area and the frequency of their occurrence were studied in the article. The main theories of the origin of the anomalies were presented. The special attention was paid to the additional diagnostic methods.
STUDY OF THE EFFECT OF TRIPTERYGIUM WILFORDII EXTRACT ON THE LEVEL OF JANUS KINASE 1 EXPRESSION IN HUMAN MONONUCLEAR CELL CULTURE
Authors:   Medical Institute of Continuing Education, Russian Biotechnological University (ROSBIOTECH), Moscow, Russia, Volchek I.A. ,   Research Center for Immunology and Allergology, Moscow, Russia, Teryaev A.S. ,   Research Center for Immunology and Allergology, Moscow, Russia, Gladko O.V. ,   Medical Institute of Continuing Education of the Russian Biotechnological University (ROSBIOTECH). Moscow, Russia, Novozhenov V.G. ,   Branch of Military Medical Academy named after S.M. Kirov of the Ministry of Defense of the Russian Federation, Moscow, Russia
Published: November 2024

Background. Tripterygium wilfordii is one of the important components of traditional Chinese medicine. Modern research has revealed the anti-inflammatory, antitumor, and metabolism-regulating properties of this plant. Some components of Tripterygium wilfordii were obtained and chemically characterized. The molecular mechanisms of their action are under study. However, studies of Tripterygium wilfordii total extracts are still rare.Purpose. To examine the effect of Tripterygium wilfordii extract on JAK1-kinase expression and interleukin 6 production in human mononuclear cells. Materials and methods. The effect of different concentrations of Tripterygium wilfordii extract on the level of spontaneous and phytohemagglutinin-stimulated JAK-1 expression and interleukin 6 synthesis was determined in cell cultures from healthy donors. Results. The induction of JAK1-kinase expression was observed under the influence of PHA, the level of which significantly increased compared to the negative control. Using the extract at a concentration of 1 μg significantly reduced the level of the enzyme, a tendency to decrease when using lower concentrations was observed. However, these changes turned out to be statistically unreliable. The results obtained were positively correlated with changes in the synthesis of JAK1/JAK2-dependent interleukin 6. Conclusions. Tripterygium wilfordii extract has a dose-dependent inhibitory effect on the synthesis of in vitro Janus kinase 1 by human mononuclear cells, which correlates with inhibition of JAK1/JAK2-dependent interleukin 6 production.
PRESERVATION OF SCARPA'S FASCIA AS THE MAIN SURGICAL STRATEGY TO PREVENT SEROMA FORMATION DURING ABDOMINOPLASTY
Authors:   Medical Institute of Continuing Education, Russian Biotechnological University (ROSBIOTECH), Moscow, Russia, Folomeeva L.I. , Pakhomova R.A. ,   Medical Institute of Continuing Education, Russian Biotechnological University (ROSBIOTECH), Moscow, Russia
Published: November 2024

Successful abdominoplasty has a positive effect on self-esteem and improves the patients' quality of life. At the same time, this intervention is characterized by a relatively high level of complications. One of the controversial aspects of these interventions is the preservation of Scarpa's fascia during abdominoplasty. Purpose: To analyze literature data on the effect of Scarpa's fascia preservation on the incidence of abdominoplasty complications. Most studies have shown that the most frequent complications in this group of interventions are local complications, including seroma, hematoma, wound dehiscence, a wound infection leading to necrotic tissue damage. Seroma, which is defined as an accumulation of serous fluid between the skin and the rectus fascia, is the most common complication, with an frequency of 5–43%. The results of a number of studies indicate thatpreservation of Scarpa's fascia on the aponeurosis of the muscles of the anterior abdominal wall is accompanied by a decrease in the volume of fluid separated by drainage, statistically significantly associated with a decrease in the incidence of seroma, a reduction in the average duration of drainage, and a decrease in hospital stay.
A CLINICAL CASE OF LARGE SEROMA AFTER SECONDARY ABDOMINOPLASTY COMPLICATED BY AN ASCENDING INFECTION
Authors:   Medical Institute of Continuing Education, Russian Biotechnological University (ROSBIOTECH), Moscow, Russia, Malanichev M.Yu. ,   LLC "Omega" (Plastic Surgery Clinic "Forma"), Moscow, Russia, Vrachev V.Yu. ,   LLC "Omega" (Plastic Surgery Clinic "Forma"), Moscow, Russia, Gabeev A.I. ,   LLC "Omega" (Plastic Surgery Clinic "Forma"), Moscow, Russia, Garipov R.R. ,   LLC "Omega" (Plastic Surgery Clinic "Forma"), Moscow, Russia, Zakirov E.Z. ,   LLC "Omega" (Plastic Surgery Clinic "Forma"), Moscow, Russia
Published: November 2024

The main aspects of complications after abdominoplasty were studied, and a conservative and surgical algorithm for the treatment of seroma after secondary abdominoplasty was formed. Special attention was given to the peculiarities of the clinical course of seroma with an associated infection, its diagnostic and treatment methods, and evaluation of the effectiveness of the treatment.
AN INTEGRATED APPROACH TO THE TREATMENT OF NECK WOUNDS: FROM OPEN SURGERY TO ENDOVASCULAR TECHNIQUES
Authors:   Medical Institute of Continuing Education, Russian Biotechnological University (ROSBIOTECH), Moscow, Russia, Ivanov A.V. ,   National Medical Research Center for High Medical Technologies, Central Military Clinical Hospital named after A.A. Vishnevsky of the Ministry of Defense of the Russian Federation, Krasnogorsk, Russia,   Peoples' Friendship University of Russia, Moscow, Russia, Shabaev R.M. ,   Medical Institute of Continuing Education, Russian Biotechnological University (ROSBIOTECH), Moscow, Russia,   National Medical Research Center for High Medical Technologies, Central Military Clinical Hospital named after A.A. Vishnevsky of the Ministry of Defense of the Russian Federation, Krasnogorsk, Russia, Ivanov V.A. ,   The Branch of the Military Medical Academy named after S.M. Kirov of the Ministry of Defense of the Russian Federation, Moscow, Russia, Antonov G.I. ,   National Medical Research Center for High Medical Technologies, Central Military Clinical Hospital named after A.A. Vishnevsky of the Ministry of Defense of the Russian Federation, Krasnogorsk, Russia,   Peoples' Friendship University of Russia, Moscow, Russia, Starokon P.M. ,   The Branch of the Military Medical Academy named after S.M. Kirov of the Ministry of Defense of the Russian Federation, Moscow, Russia
Published: November 2024

Neck wounds are a serious problem in peacetime and wartime because of the high mortality and severity of the condition of the injured. This article presents a clinical observation of a patient with a gunshot wound of the neck, injury and occlusion of the common carotid artery. The wounded person underwent subclavian-carotid allografting, which was complicated by its thrombosis and subsequent middle cerebral artery embolism. The authors describe the efficacy of multidisciplinary management of this case, including surgery and endovascular treatment. The results indicate the efficacy of surgical treatment for common carotid artery occlusions, but emphasize the possibility of unforeseen complications. An approach involving detection of ischemic stroke and endovascular treatment, including thrombaspiration and intra-arterial thrombolysis, can prevent serious complications in patients with such lesions.
BUTTERFLY CARTILAGE TYMPANOPLASTY
Authors:   Main Clinical Hospital of the Ministry of Internal Affairs. Moscow, Russia, Morozov I.I. ,   Medical Institute of Continuing Education of the Russian Biotechnological University (ROSBIOTECH), Moscow, Russia, Gorbunova N.V. ,   Main Clinical Hospital of the Ministry of Internal Affairs. Moscow, Russia, Shirokayа A.V. ,   Main Clinical Hospital of the Ministry of Internal Affairs. Moscow, Russia, Bulanov K.V. ,   Medical Institute of Continuing Education of the Russian Biotechnological University (ROSBIOTECH), Moscow, Russia
Published: November 2024

Purpose. To review the literature to evaluate the effectiveness of using the “butterfly” technique for tympanoplasty in patients with chronic suppurative otitis media (CSOM). Materials and methods. The research studies in which patients with CSOM (tubotympanic form) underwent tympanic membrane reconstruction using a butterfly cartilage graft were included. The following inclusion criteria were applied: the patients in the study had chronic tubotympanic otitis without signs of exacerbation, tympanoplasty using this technique, postoperative follow-up for at least six months, participation of the patients who underwent traditional tympanoplasty using the temporal fascia, cartilage or fat “patch” in the control groups. The exclusion criteria were CSOM with cholesteatoma, destruction of the auditory ossicles, other tympanoplasty methods than those mentioned above, the use of xenogeneic, allogeneic or other biomaterials as a graft. Results and discussion. The technique shows high efficiency (86-96%), comparable to tympanoplasty of the temporal fascia using the “underlay” technique, has technical advantages in the form of no need for an intra-auricular or post-auricular incision, mobilization of the meatotympanic flap, additional tissue separation forthe temporal fascia graft, which affects the speed of the surgery, the need for tamponade of the ear canal and the duration of the patient’s disability. The technique cannot be used if the patient has cholesteatoma and a ruptured auditory ossicular chain; the cartilage graft is technically difficult to produce for small tympanic membrane perforations without the aid of a microscope; the selection and shaping of the graft requires considerable experience and time. Conclusion. Butterfly cartilage tympanoplasty is highly effective in terms of anatomical and functional results for the treatment of small and medium tympanic membrane perforations in patients with chronic tubotympanic suppurative otitis media. Endoscopic modification of the surgery has obvious technical and economic advantages. The effectiveness of the technique for large perforations of the tympanic membrane, residual and recurrent perforations requires further comprehensive studying.
EXTRANASOPHARYNGEAL ANGIOFIBROMA. TWO CLINICAL CASES
Authors:   Dmitry Rogachev National Medical Research Center for Pediatric Hematology, Oncology and Immunology of the Ministry of Healthcare of the Russian Federation, Moscow, Russia, Vorozhtsov I.N. , Chechev E.I. ,   Dmitry Rogachev National Medical Research Center for Pediatric Hematology, Oncology and Immunology of the Ministry of Healthcare of the Russian Federation, Moscow, Russia, Grachev N.S. ,   Dmitry Rogachev National Medical Research Center for Pediatric Hematology, Oncology and Immunology of the Ministry of Healthcare of the Russian Federation, Moscow, Russia,   Medical Institute of Continuing Education, Russian Biotechnological University (ROSBIOTECH). Moscow, Russia
Published: November 2024

Juvenile angiofibroma is a rare benign mesenchymal tumor, morphologically representing a vascular proliferation in a cellular, densely collagenized stroma, usually occurring in the nasopharynx, more often in adolescent boys. Recently, an increasing number of articles have been publishedon the so-called extranasopharyngeal angiofibroma (ENA), which can occur in both boys and girls. This article describes the clinical course of ENA and presents two clinical cases of extranasopharyngeal angiofibroma.
A CLINICAL CASE OF DIAGNOSTICS OF MALIGNANT TESTICULAR TUMOR
Authors:   Main Military Clinical Hospital of the National Guard Troops of the Russian Federation, Balashikha, Russia, Chevychelov S.V. ,   Medical Institute of Continuing Education, Russian Biotechnological University (ROSBIOTECH), Moscow, Russia, Slukina I.S. ,   Main Military Clinical Hospital of the National Guard Troops of the Russian Federation, Balashikha, Russia, Muracheva N.V. ,   Main Military Clinical Hospital of the National Guard Troops of the Russian Federation, Balashikha, Russia, Nikolaeva G.K. ,   Main Military Clinical Hospital of the National Guard Troops of the Russian Federation, Balashikha, Russia
Published: November 2024

All the main processes associated with testicular masses and focal testicular changes in men. The etiology of tumors in the gonads is demonstrated. The diagnostic methods and differential diagnosis of tumors are highlighted. The tumor identified in the presented clinical case is considered from the point of view of diagnostic, morphofunctional, pathological sections of medicine.
USE OF MEMBRANE PROTECTORS FOR THE TREATMENT OF PATIENTS WITH A "LIGHTNING-FAST" FORM OF ACUTE PANCREATITIS
Authors:   Medical Institute of Continuing Education, Russian Biotechnological University (ROSBIOTECH). Moscow, Russia, Pakhomova R.A. , Gulikyan G.N. ,   Clinical hospital “Russian Railways-Medicine”, Krasnoyarsk, Russia, Кlimenko K.V. ,   Medical Institute of Continuing Education, Russian Biotechnological University (ROSBIOTECH), Moscow, Russia, Kozlov V.V. ,   I.M. Sechenov First Moscow State Medical University, Moscow, Russia
Published: November 2024

Background Acute pancreatitis, which causes a huge number of complications, has been and remains one of the most serious diseases in urgent surgery. Despite the currently existing algorithms for the diagnosis and treatment of acute pancreatitis, a number of unresolved issues remain that require further studying. Purpose. To substantiate the effectiveness of the use of membrane protectors in the complex treatment of acute pancreatitis. Material and methods. The retrospective stage (2016–2018) included 30 patients diagnosed with acute pancreatitis who received standard treatment. The prospective stage (2018–2020) included 31 patients diagnosed with acute pancreatitis (AP). In addition to the complex treatment for these patiets, membrane protectors were used in the pre- and postoperative period. The groups were comparable in age and extent of the pancreatic lesion. During the study, in addition to the standard surgical treatment, the patients received the drug “Neurox” in the pre- and postoperative period. Results. The use of membrane protectors is justified, on day 14 there was a statistical decrease in erythrocyte membrane ruptures. Discussion. In recent years, there has been an increase in the number of studies investigating the effect of membrane protective therapy on the course of acute pancreatitis in general, and destructive forms in particular.Some publications note the effectiveness of combined membrane protective and antioxidant therapy in destructive pancreatitis. Conclusion. The use of membrane protectors in the complex treatment of acute pancreatitis is pathogenetically justified and can be used for the therapeutic correction of acute pancreatitis, taking into account the developing morphofunctional processes.
Hoogbegaafd en psychosociale normaliteit. Hoezo segregatie?
Authors: Besjes-de Bock Karin
Published: November 2024

Het thema segregatie lijkt op het eerste gezicht weinig verband te houden met hoogbegaafde kinderen; integratie is het parool. Echter, zowel ontwikkelingspsychologische concepten als pedagogische aandacht voor het psychosociaal functioneren van hoogbegaafde kinderen concentreren zich op het verschil tussen psychosociale normaliteit en non-normaliteit en het onderscheiden van een specifieke groep. Bio-psychologische, sociaal-psychologische en geïntegreerde opvattingen over psychosociale gezondheid en hoogbegaafdheid droegen en dragen bij tot gebruik van scheidslijnen. Zij initiëren op hoogbegaafde kinderen gerichte interventie-praktijken. In huidige interventiedoelen voor een optimale psychosociale gezondheid zijn verbanden tussen hoogbegaafdheid en segregatie gemaskeerd doch stevig aanwezig.
Leidt inclusie tot minder uitsluiting van mensen met een licht verstandelijke beperking?
Authors: Moonen Xavier
Published: November 2024

In onderwijs en zorg voor mensen met een licht verstandelijke beperking (LVB) staan inclusie, passend onderwijs en ondersteuning centraal. Inclusie krijgt geleidelijk aan vorm in Nederland en zorgt er voor meer en betere maatschappelijke participatie. Het succes van inclusie ligt in handen van de politiek, van de mensen met een LVB zelf, van organisaties maar ook van professionals. In onderwijs en zorg zijn er twijfels over de praktische haalbaarheid en over de professionaliteit van de leerkrachten, zorgverleners en organisaties. Zeker als er bezuinigd wordt. Inclusie vraagt om een nieuwe dialogische manier van werken en een heroriëntatie op de professionele ondersteuning van mensen met een LVB. Naast ruimte geven moet ook bescherming geboden worden tegen de gevaren die zij in de samenleving ontmoeten. Dit legitimeert de professional om naast een ondersteunende ook een assertieve en soms een directieve vorm van ondersteuning te bieden. Onderwijs- en zorgprofessionals moeten gedegen kennis hebben van specifieke kenmerken van de kinderen en volwassenen met een LVB. Als er in onderwijs en zorg niet volmondig gekozen wordt voor professionalisering in relatie tot inclusie, bestaat de kans dat mensen met een LVB (opnieuw) gesegregeerd zullen gaan worden.
De Roma: probleem of spiegel voor onze samenleving? Een exploratie van pedagogische kansen
Authors: Hemelsoet Elias
Published: November 2024

De ‘Romaproblematiek’ is alomtegenwoordig in de media. Na een schets van de veranderende maatschappelijke context ten gevolge van nieuwe migratiestromen van Oost naar West-Europa, staat dit hoofdstuk stil bij de verschillende wijzen waarop Roma maatschappelijk geproblematiseerd worden; respectievelijk gaat het om een ordehandhavingsprobleem, een cultuurprobleem en een armoedeprobleem. De vraag is of we Roma per definitie als een probleem moeten bekijken. Geen enkel van de voorgenoemde probleemdefinities valt immers samen met de Roma als doelgroep. De praktijk biedt genoeg tegenvoorbeelden: er zijn Roma die zich niet inlaten met criminele praktijken, niet beantwoorden aan de culturele eigenschappen die deze groep worden toegeschreven en evenmin in armoede leven. Dat neemt niet weg dat er sprake is van sociale problemen waar beleidsmakers wel degelijk mee aan de slag moeten. Een andere probleemdefiniëring lijkt pedagogisch alvast vruchtbaarder om die uitdaging aan te gaan. ‘Het Romaprobleem’ kan dan bekeken worden in termen van samenlevingsproblemen; het gaat om processen die vorm krijgen in dynamische interacties binnen een context. Het laatste deel sluit aan bij een praktijkvoorbeeld dat toont hoe een andere blik om deze mensen tegemoet te treden wel degelijk mogelijk is. Eerder dan de zoektocht naar een oplossing voor het Romaprobleem in onze samenleving, dwingt dit voorbeeld ons tot een blik in de spiegel en roept het de vraag op wat we als samenleving uit deze problematisering over onszelf kunnen leren.
“Sinds wanneer zijn de moeders, die thuis hun kinderen zélf opvoeden, sufferds?” Debatten rond vrouwenemancipatie in Vlaamse educatieve televisieuitzendingen voor vrouwen (1954-1966)
Authors: Flamez Evelien , Vanobbergen Bruno
Published: November 2024

Deze bijdrage gaat in op hoe vrouw-zijn en vrouwenemancipatie als pedagogische concepten werden gedacht in vrouwenuitzendingen op de BRTN tussen 1954 en 1966. Met de classificatie van de vrouwenuitzendingen in de ‘Dienst Artistieke en Educatieve Uitzendingen’ van het NIR/BRTN, werden deze uitzendingen expliciet als educatief erkend en het opvoedingsproject voor vrouwen van dat van mannen onderscheiden. Hoewel de uitzendingen in het leven werden geroepen om de participatie van vrouwen te verhogen, werd de segregatie van mannen bijgevolg nog meer in de verf gezet. In deze bijdrage willen we op basis van een analyse van enkele uitzendingen, alsook van kijkersbrieven op zoek gaan naar de paradoxale effecten van dit emancipatorisch educatief project. Enerzijds werden vrouwen als groep in de algehele educatieve/culturele missie van de Belgische televisie geïntegreerd; anderzijds segregeerde deze a priori categorisering vrouwen als te onderscheiden groep. Ondanks het emancipatorische project werden aldus limieten ingesteld door vrouw-zijn te ‘sluiten’ in termen van een voorgesteld ideaal van ‘de geëmancipeerde vrouw’.
The Relationship between Raised Mean Platelet Volume and Severity of Newly Diagnosed Acute Ischaemic Stroke
Authors: Rahim Choudhury Faisal Md. Manzurur , Ahmed Qumrun Nassa , Rahman Md. Ashikur , Ali Md. Haider , Hasan Mohammad Kamrul , Rahman Md. Mahbubor , Karim Prof. Md. Enamul
Published: November 2024

Introduction and Objective: Stroke is one of the leading causes of mortality and long-term disability throughout the world. Mean platelet volume (MPV), a marker of platelet activation, is calculated and provided by automatic blood cell count equipment during routine complete blood count analysis is a surrogate marker of platelet function and a potential mediator of the association between inflammation and thrombosis. So, to investigate MPV in ischaemic stroke and its role to discriminating more severe stroke from mild one the current study was done. Methods: This observational case control study was carried out in Department of Medicine, Dhaka Medical College Hospital (DMCH) from July 2015 to June 2016. 100 patients with attack of ischaemic stroke who presented within 24 hours of symptoms onset were divided into 2 groups (group-1: mRS score 0-2, and group-2: mRS score 3 or more) based on severity. Severity of ischaemic stroke was assessed by the modified Rankin Scale. At the same time 100 age and sex matched controls were taken. Blood samples were collected from both groups and MPV was measured. The results were statistically compared by SPSS 22.0. Statistical significance was accepted at <0.05. Results: The MPV values were more in case group in comparison to control group (10.88±1.23 vs 10.03±1.03; z score-5.31; p value <0.01). Comparison between the 2 groups revealed that MPV value was higher and more significant in group 2 of cases than group 1(10.15± 0.739 in group 1 versus 11.63± 1.04 in group having 2; z score-7.7, p value <0.001). 6 patients of group 2, who could not overcome the situation and died within 24 hours of admission had MPV value of 12.92±0.30. After controlling the risk profiles associated with ischaemic stroke by means of binary logistic regression model, the effect of MPV in ischaemic stroke remained statistically significant (OR: 4.418, 95% CI 2.468-7.908, p= 0.000). ROC curve was 0.85 and standard error 0.039 (95% CI: 0.779-0.932; p<0.01), ...