bluuebunny/crossref_metadata_2025 huggingface dataset:
To Read and to Feel: The Multimodal Representation of Emotions in Digital Children’s Literature
Authors: Frederico Aline
Published: August 2024

ABSTRACT Digital literature presents new ways of constructing aesthetic and emotional experience for child readers. This article reflects on emotion and affect in digital literature through the analysis of three literary apps for children. To deal with the complex phenomenon of the affective and emotional experience in digital reading, an interdisciplinary theoretical framework is proposed, relating Merleau-Ponty’s phenomenology to Kress and van Leeuwen’s multimodal social semiotics. The corpus includes the apps Little Red Riding Hood, by producer Nosy Crow, The Monster at the End of This Book, by Jon Stone and Michael Smollin, and Hat Monkey, by Chris Haughton. It discusses how different semiotic resources are used in the representation of emotions and in suggesting emotional tension to the child reader, with embodiment and the intrinsic relationship between reader’s bodies and their emotional experience as a central part of apps’ textual construction.
Modelo poético de lugares sagrados
Authors: Mirazova Marzhan , Aimukhambet Zhanat , Bultanova Zhibek , Sabiyeva Yelena , Ahmetova Tatyana
Published: August 2024

RESUMO A interpretação poética do simbolismo dos lugares sagrados é um tema significativo no estudo da herança cultural do Cazaquistão, incluindo a sua literatura. Esta pesquisa tem como objetivo analisar as técnicas literárias e as táticas linguísticas através das quais os escritores cazaques recriam e ilustram o simbolismo e o significado dos locais sagrados. O principal método utilizado é o analítico, especificamente a análise semiótica, a análise formal e a análise histórico-cultural. Outros métodos empregados incluem comparativos, métodos de generalização e sistematização. O estudo concluiu que os locais sagrados desempenham um papel fundamental na identificação nacional do Cazaquistão. A sua interpretação poética mostra um complexo entrelaçamento de memória histórica, tradições culturais e valores espirituais do povo cazaque. A análise das obras literárias revelou que os escritores empregam ativamente várias técnicas estilísticas e rítmicas para transmitir o significado único destes lugares. Metáforas, alegorias, símbolos, repetições e outras ferramentas linguísticas são mais comumente usadas para criar uma imagem em várias camadas de um local sagrado.
Entoação visual negra em experimento audiovisual de Arthur Jafa
Authors: Machado Irene
Published: August 2024

RESUMO O objeto de estudo do presente artigo é o conceito de entoação visual negra formulado pelo multiartista Arthur Jafa no vídeo-ensaio Love Is the Message, the Message Is Death (2016). Com o objetivo de descobrir a singularidade do cinema negro na composição fílmica, o artista construiu um experimento e examina como memórias encarnadas afloram sob forma de cantos e danças, realinhando formas culturais tradicionais que a travessia diaspórica dispersou. Conclui-se, assim, que a singularidade estético-política do cinema negro emerge na entoação verbi-voco-visual negra que, assim, exterioriza energias interiores interativas e organiza um espaço crítico-discursivo no qual pessoas pretas podem falar de si, de seus desejos, sonhos e aflições.
Por que a carteira de vacinação do Ex-Presidente da República é um documento público?
Authors: Cunha Filho Marcio
Published: August 2024

Resumo Em 2021, no ápice da maior crise sanitária que o mundo experimentava desde a pandemia de 1918-1919, vacinas com alto grau de segurança e efetividade foram produzidas em tempo recorde, e começaram a ser distribuídas mundo a fora. O então Presidente da República do Brasil, que desde o início da crise sanitária vinha promovendo um discurso falso tentando minimizar a gravidade da nova doença e da crise sanitária, bem como promovendo falsas curas como o uso de remédios comprovadamente inefetivos para tratar o novo coronavírus, começou então uma campanha anti-vacinação. Seus discursos, suas falas e seus gestos tinham o intuito de embutir a dúvida nas pessoas acerca da segurança e da efetividade da vacina no Brasil. Ao mesmo tempo, ele afirmava consistentemente que não se vacinara e não se vacinaria. Muitos começaram a se perguntar sobre a existência de provas acerca da ocorrência de vacinação ou não, mas o governo sempre negava pedidos de acesso à informação, afirmando tratar-se de documento pessoal sensível. O objetivo deste artigo é construir um argumento sobre o porquê de a carteira de vacinação de um Presidente da República ser, ao menos nesse contexto da COVID, um documento de natureza pública, que deve ser de acesso público a todo e qualquer interessado. Chego a essa conclusão a partir do desenvolvimento das seguintes premissas: agentes públicos em geral e o Presidente da República em particular têm uma expectativa reduzida de privacidade; as palavras, gestos e atitudes do Presidente da República têm influências concretas sobre as pessoas e, no contexto pandêmico, podem ter causado mortes evitáveis; as informações contidas na carteira de vacinação do Ex-Presidente são necessárias para fins de responsabilização; o consentimento do titular de informações pessoais sensíveis torna-as públicas.
Democracia, Populismo e o que se segue
Authors: Savedra Alan Paulo Maurano
Published: August 2024

Resumo Cuida-se de resenha crítica acerca da obra O século do populismo: história, teoria e crítica, do historiador e cientista político francês Pierre Rosanvallon. O populismo atrai a atenção de muitos pesquisadores mundo afora e, apesar disso, a compreensão do fenômeno ainda se encontra distante de um consenso. A partir dessa resenha, busca-se analisar a contribuição dada por Rosanvallon à compreensão de uma tipologia do populismo. Ao final, nota-se que, para Rosanvallon, além de uma possibilidade dentro da própria democracia, o populismo também pode significar a força propulsora que a transforma em uma ditadura.
Política autocompositiva: câmaras privadas no cenário nacional
Authors: Moura Gisele Luiza Soares , Dufloth Simone Cristina
Published: August 2024

Resumo O objetivo deste artigo é analisar o uso de métodos adequados de resolução de conflitos - como a conciliação e a mediação -, bem como a incorporação de soluções tecnológicas para esse fim. Para contextualizar o fenômeno na seara nacional, foram analisadas, especificamente, as instituições dedicadas à resolução de conflitos por meios alternativos ao processo judicial, registradas como câmaras privadas nos Tribunais de Justiça. Metodologicamente, adotou-se uma abordagem descritiva, por meio da revisão de literatura, de pesquisa documental, do envio de questionários às câmaras privadas e da realização de entrevistas. Constatou-se que o fenômeno observado é heterogêneo no país em relação à quantidade e à distribuição de câmaras privadas, à sua natureza jurídica e aos métodos por elas utilizados. Verificou-se também a incorporação de tecnologia nas câmaras privadas, com destaque para as iniciativas totalmente automatizadas (ODR). O estudo contribui para a sistematização de informações dispersas e para o aprofundamento da pesquisa sobre um tema atual e com escassa literatura disponível.
Analysis of heart rate variability to identify hearing loss in the first year of life
Authors: Silva Bárbara Cristiane Sordi , Jacob Lilian Cássia Bórnia , Valenti Vitor Engrácia , Araújo Eliene Silva , Alvarenga Kátia de Freitas
Published: August 2024

ABSTRACT Purpose to investigate the existence of an association between Heart Rate Variability (HRV) and hearing sensitivity in healthy children in the first year of life, using the RMSSD (Root Mean Square of Successive Differences) and SD1 (Poincaré plot standard deviation perpendicular to the line of identity) indices. Methods this is a methodological study with evaluation of 20 children divided into two groups: 10 children without hearing loss (G1) and 10 children with hearing loss, regardless of type and/or degree (G2). The click stimulus was presented at intensities of 30-60 dB nHL. To capture the HRV, a Polar RS800CX heart monitor was used, with a sample rate of 1.000 Hz. Stable sets with 60 R-R intervals were selected and only those with more than 95% sinus beats were included. The analysis of the 2-way repeated measures ANOVA test was used to evaluate the effects of acoustic stimulation on the RMSSD and SD1 indices, in silence and in the presence of the click stimulus, in groups G1 and G2. The factor analysis was applied to evaluate the indices with the factors sex, tested ear, behavioral state of the child and test period. Results there were no significant differences for the RMSSD and SD1 indices, in silence and in the presence of the click stimulus, in groups G1 and G2, and between both groups. There was no interaction between the HRV indices, and all the analyzed confounders. Conclusion there was no association between HRV and hearing sensitivity, so the HRV researched with click stimulus at intensities of 30-60 dB nHL was not effective to identify children with hearing loss in the first year of life, through the RMSSD and SD1 indices.
Variability of speech rate and articulatory transition ability
Authors: Peres Larissa Maria , Juste Fabiola , Costa Julia Biancalana , Sassi Fernanda Chiarion , Ritto Ana Paula , Andrade Claudia Regina Furquim de
Published: August 2024

ABSTRACT Purpose To analyze speech rate by applying two different methods: speech rate analysis considering the ratio of time/ fluent stretches of the sample and considering the ratio of time/200 fluent syllables Methods The speech samples from 73 participants of both genders, Brazilian Portuguese speakers, were analyzed. The analysis was carried out based on the parameters of Fluency Profile Assessment Protocol and compared regarding: speech rate (syllables per minute) and total time of the speech sample (in both reference and proposed methodology). Results The significant positive correlations found in the three analyses indicate that the variables concerning the measurement of speech rate by the two methods of analysis are related and move together. Conclusion Although the proposed methodology has proven to be effective, it proved unfavorable in comparison because it reflects proportionally the same results as the traditional methodology, but demands more time and manual resources.
A economia política da violência e da morte
Authors: Guéron Rodrigo
Published: August 2024

Resumo O artigo a seguir busca elucidar o conceito de “economia-política da violência e da morte”, que propomos como uma definição possível de fascismo. Trabalhamos com este conceito pela primeira vez no livro A Vingança dos Capatazes. O bolsonarismo como Fascismo (Guéron, 2022). Pretendemos mostrar como a filosofia política de Felix Guattari, sobretudo depois do seu encontro com Gilles Deleuze, foi decisiva para chegarmos a este conceito, isto é, para definirmos isso que compreendemos como um fluxo de violência e morte típico da máquina social capitalista. Violência e Morte que circula de forma imanente, tanto como forma-mercadoria -- como uma forma hiper eficaz de produção de mais valia e lucro, quanto como uma intensa, e atraente economia libidinal.
For a philosophical history of ‘nosotros’ The Latin American perspectives of Juan Carlos Scannone and Ricardo Espinoza Lolas
Authors: Sgarro Tommaso
Published: August 2024

Abstract This essay is a further contribution to the history of the idea of ‘We’ in philosophy. The perspectives of the two Latin American authors Juan Carlos Scannone and Riccardo Espinoza Lolas contribute to the reconstruction of a history of philosophy in a global sense that has the theme of nosostros at its centre. They are part of the same philosophical tradition, inscribed within the philosophy of liberation, but they interpret the question through contiguous but not directly overlapping characteristics. We are thus defining a modality of approach to the history of philosophy, of its ideas that through the disarticulation of the geo-textual places in which the pronoun nosostros becomes concept, idea, interpretative paradigm, goes on to outline some interpretative proposals for contemporaneity.
Abordagem comparativa sobre o financiamento esportivo dos entes subnacionais de Brasil e Portugal
Authors: Athayde Pedro Fernando Avalone , Marques Luís Maurício Montenegro , Figueiredo António José Barata
Published: August 2024

RESUMO O artigo aborda o financiamento público do esporte em entes subnacionais do Brasil e Portugal, com uma ênfase na comparação entre os dois contextos. O objetivo é descrever e analisar comparativamente o financiamento público do esporte nestes países. O estudo é caracterizado como uma pesquisa qualitativa combinada com análise descritiva, utilizando principalmente pesquisa documental. Conquanto haja diferenças na organização das fontes de recursos públicos para o esporte, os entes subnacionais de ambos os países participam destacadamente no financiamento deste setor. Embora o Brasil gaste mais em termos absolutos, os municípios portugueses têm despesas proporcionais mais elevadas.
Investigating the potential of incorporating concrete floor polishing sludge waste in permeable concrete
Authors: Santos Igor Soares dos , Nahime Bacus de Oliveira , Akasaki Jorge Luís , Lima Elton Carvalho de , Alves Michell Macedo , Reis Idalci Cruvinel , Silva Lorena Araújo , Barella Netto Alberto
Published: August 2024

Abstract With the increase in floods in urban areas, the use of permeable pavement has become increasingly advantageous. In this context, the objective of this study was to evaluate the influence of the addition of concrete floor polishing waste (CFPW) on the physical, mechanical, and microstructural behavior of permeable concrete. Three different mixtures were evaluated: a reference sample determined based on the literature review and dosed with natural aggregates and two other samples with the addition of 2% CFPW and 4% CFPW, respectively, in relation to cement mass. When comparing the dosages of 2% CFPW and 4% CFPW to the reference sample, there was an increase in the average compressive strength of 57.45% and 33.78% for three days of curing, and 45.41% and 37.20% for seven days of curing. Furthermore, the flexural strength of 2% and 4% CFPW samples exhibited a superior performance of 55.70% and 58.75%, respectively, compared to the control after three days. At 28 days of age, the 4% CFPW composition showcased a 16.3% increase relative to the control and an 11% improvement compared to the 2% CFPW composition. For the permeability tests, no significant variations were observed. For the 2% CFPW and 4% CFPW samples, respectively, a reduction in the void ratio was observed to 25.08% and 12.44%. A good correlation between compressive and flexural strengths was determined.
Sexuality in female patients on hemodialysis: a scoping review protocol
Authors: Imhof Solange , Nerbass Fabiana Baggio , Ribeiro Heitor S. , Santos Rafaela Gonzaga dos , Nilson Luana Gabriele
Published: August 2024

Sexuality is a human biological function that is not limited only to genitality but to total corporeality. Sexual function is a complex biopsychosocial phenomenon in which internal and external stimuli are modulated by the central and peripheral nervous system, resulting in biochemical, hormonal, and circulatory changes that culminate in physical and cognitive sexual results. Several conditions influence sexuality, and one of the diseases that can impair female sexual function and impact sexuality is chronic kidney disease. Considering the complexity and specificity of chronic kidney disease, the significant repercussions of hemodialysis treatment on the lives of patients, and the scarce scientific production, the need to delve deeper into the topic was perceived since the experience of sexuality of these women is relevant in the quality of life and not usually addressed by health professionals. To investigate the topic in-depth, a scoping review will be developed on the sexuality of female people undergoing hemodialysis treatment, regardless of their sexual orientation. The objective of this work is to map the production of knowledge about sexuality in women undergoing hemodialysis treatment. The search for publications will be carried out in the following databases and bibliographic index: Medical Literature Analysis and Retrieval System Online (MEDLINE via PubMed), Web of Science, in the Bibliographic Index of Latin American and Caribbean Literature in Health Sciences (LILACS) and APA PsycNet. In addition to these databases, the research will also include gray literature, such as Google, Google Scholar, and YouTube. The question that will guide the review is: "What is the current knowledge about sexuality in women on hemodialysis? The review will consider studies that include the terms "sexuality", "women" and "hemodialysis", without restrictions on language and date.
Enhancing Microemulsion-Based Therapeutic Drug Delivery: Exploring Surfactants, Co-Surfactants, and Quality-by-Design Strategies within Pseudoternary Phase Diagrams
Authors: Bamanna Abhishek , Rajora Anjali , Nagpal Kalpana
Published: August 2024

Microemulsions (MEs) are homogeneous, isotropic, transparent, and thermodynamically stable mixtures of water, oil, and surfactants. Their unique properties have garnered increasing interest across various fields, including chemistry, pharmacology, biotechnology, and
biology. This review aims to provide a comprehensive overview of ME compositions, their macroscopic appearances, and the roles of their essential components-oil, water, surfactant, and co-surfactant-in controlling the nature and stability of MEs. The review highlights the significance of MEs in drug delivery and other applications, highlighting their potential to enhance the
solubility, stability, and bioavailability of active pharmaceutical ingredients (APIs). Key factors
influencing ME formation, such as the types of surfactants, oils, water, temperature, and various additives, are thoroughly explored. The physicochemical properties of MEs, including small droplet size, large interfacial area, and solubilization capabilities for both hydrophilic and hydrophobic compounds, are discussed about their impact on biological behavior. The present work is an effort to discuss theories and phase diagrams crucial for ME formation, and the strategy of choosing appropriate surfactants and co-surfactants. and the advancements in the preparation and characterization techniques like the shift from visual inspection to advanced spectroscopic phase
behavior studies. The work also describes the potential of MEs in drug delivery showcasing the most commonly used ME-based drug candidates as well as excipients highlighting how different excipients influence the release of active pharmaceutical ingredients and the way and quality-by-design approach has been utilized to optimize MEs, providing insights into the systematic design and development to achieve desired characteristics of ME formulations.
Clinical Experience of Dissolvable Calcium Sulfate (Stimulan) Carrier for Antibiotic Delivery in Orthopedic Surgery: A Study of 143 Patients
Authors: Shah Nilen A. , Shah Ronak V. , Patel Vihalkumar D. , Patel Deepak V.
Published: August 2024

Prosthetic bone and joint infections are difficult to treat with varying levels of success with standard therapy. Synthetic calcium sulfate carrier, to which specific antibiotics can be added, can be utilized as an alternative drug delivery system in these cases. We have reviewed clinical outcomes using commercially available pure synthetic calcium sulfate dissolvable beads (Stimulan) loaded with antibiotics in 143 patients undergoing orthopedic surgery for prevention and treatment of joint infection. Stimulan was added after standard surgical procedure in cases of: (1) Established infections, (2) Second stage of previously infected patients, or (3) High risk of infection. The purpose of this study was to (1) Evaluate the efficacy of Stimulan for eradicating the infection in patients with established infection, and (2) To study the efficacy of Stimulan for preventing infection in previously infected and healed, or high-risk group of patients. Established orthopedic surgical procedures (such as debridement, liner exchange, one-stage or two-stage revision surgery, or culture-specific systemic antibiotic therapy) were carried out to treat infection, and Stimulan was added in the medullary canal and soft tissue. In addition, postoperative infection and other complications were recorded. This prospective study data showed postoperative wound drainage in 4.9% and infection in 9.1% of total patients. Success rate after the use of Stimulan was 84.9% for established infected patients, 90.9% for previously infected patients, and about 97% for high-risk group patients. Based on the results of this study, we conclude that Stimulan is an acceptable novel drug delivery system for local antibiotic in septic or aseptic standard orthopedic surgeries. Moreover, postoperative infection rate was lower than any other antibiotic delivery system or drugs used before. Stimulan is also effective as a preventive measure for infection-prone patients.
An Organizational Recovery Paradox in Managing Working Hours, Staffing, and Recovery During the COVID-19 Pandemic – a Qualitative Study
Authors: Hernandez Isabelle , Arakelian Erebouni , Rudman Ann , Dahlgren Anna
Published: August 2024

The COVID-19 pandemic put pressure on healthcare organizations, making them dependent on sufficient resources and employees’ performance. Recovery is a key factor in maintaining safe operations, employee health, and retention. However, during the pandemic, working hours became more demanding, which limited time for recovery between shifts. The responsibility to ensure employee recovery in relation to working hours lies at the organizational level. The aim of this study was to examine how working hours, staffing, and recovery were managed at the organizational level during the COVID-19 pandemic in Swedish health care, studied from the perspective of HR representatives. Qualitative interview data based on 19 HR representatives from 16 Swedish regions was analyzed using thematic analysis. The results showed that during the COVID-19 pandemic, organizations maximized working hours and reorganized employees, care, and HR. Actions were taken to buffer job demands, including providing support and identifying employees who were not feeling well. Inadequate staffing and skill mix influenced the management of working hours, staffing, and recovery. Our findings highlight the use of short-term solutions to manage the situation at hand, which could lead to exhaustion of human capital long-term and subsequent effects on safety, performance, and employee retention. We term this phenomenon the organizational recovery paradox.
A tale of two Tagalogs
Authors: Pizarro-Guevara Jed Sam , Wagers Matthew
Published: August 2024

A well-received generalization in Tagalog is that only the argument that is cross-referenced by voice is eligible for A-bar extraction. However, recent work has shown that agents that are not cross-referenced by voice are also eligible. We provide naturally occurring data, along with experimental evidence, consistent with this more permissive picture. Further, we present computational evidence that participants were treating agent-extractions not cross-referenced by voice categorically, that is, they were either accepting or rejecting them in any given trial. Thus, we identify a piece of grammatical knowledge (i.e., extraction) that is systematic within an individual speaker but varies unpredictably across a population of Tagalog speakers. In other words, our data reveal two separable types of Tagalog speakers vis-à-vis extraction. We propose that this is a form of grammar competition that arises via the idea that the agent-first bias affects how child learners parse input strings under noisy conditions during acquisition.
The Soul of the Frog for a Postmodern Age
Authors: Miller Gordon Lynn
Published: August 2024

The history of modern science bears abundant witness to the fact that the humble frog has yielded myriad insights into the intricacies of anatomy and physiology far beyond frogs, producing several Nobel laureates in the process. A concurrent but less heralded inquiry and debate, however, has wrestled with the harder question of, as Thomas Henry Huxley put it in 1870, “Has a Frog a Soul?,” with frogs serving as convenient experimental subjects for issues of the human soul and body. Here, I present highlights from this debate among leading eighteenth- and nineteenth-century scientists representing animistic and burgeoning mechanistic views, with the latter effecting a significant contraction of soul, ending with William James in 1890. I then bring the inquiry up to date by showing how Alfred North Whitehead’s philosophy of organism and some recent physiological research offer promising and constructive postmodern hope for addressing the dispiriting loss of soul, on various levels, that afflicts much of modern life.
La experiencia de vida y del juego para fortalecer las capacidades expresivas-comunicativas desde la Educación Física
Authors: Cuervo-Jiménez Daniel Stiven , Bennasar-García Miguel Israel
Published: August 2024

El objetivo principal del presente estudio fue analizar la experiencia de vida y del juego para fortalecer las capacidades expresivas-comunicativas desde la Educación Física. La investigación estuvo circunscrita en el paradigma cualitativo por la ausencia de datos numéricos o comparaciones de variables. La metodología prisma fue la utilizada, a fin de recabar las informaciones de interés investigativo apoyado en la revisión bibliográfica como técnica de búsqueda y de arqueo documental. La experiencia de encontrarse con el juego como fundamento de la teoría, ofreció una oportunidad de comprender una línea y métodos alternos a los comúnmente utilizados, suponiendo y esperando que, aproximaciones pedagógicas que propicien la expresión y la comunicación en pro de una mejor vivencia educativa. Como resultado se puede expresar que el juego como un saber dentro de la Educación Física nos permite integrar elementos esenciales para la comprensión de la conducta social del individuo, para darle sentido a la vida desde las normas de libertad, el goce y la espontaneidad. Dentro de las conclusiones, la praxis en las dimensiones del sujeto y se hace en y desde la concepción vital, por talmotivo se considera que debe ser un proyecto disciplinar que se debe emancipar para la educación verdaderamente de calidad y significativa.
Fútbol y empoderamiento de la mujer: sistematización de experiencia
Authors: Durán Víctor Hugo , Fonseca-Franco Ingrid
Published: August 2024

La presente investigación se realiza en el marco del Convenio 544 de 2022 subscrito entre el Fondo de Desarrollo Local de Suba y la Universidad Pedagógica Nacional como parte de las iniciativas de participación ciudadana del año 2022. El artículo resultado de investigación sistematiza la experiencia de implementación del evento: “Mujeres empoderadas por el fútbol”, una de las estrategias ganadoras de los presupuestos participativos, desarrollada con mujeres futbolistas de la localidad; pone en tensión los discursos sobre mujer en el deporte, las barreras de género y la inclusión, con las iniciativas de formación comunitaria y acciones gubernamentales que pretenden la reivindicación de derechos, según se infiere de los términos de referencia de la iniciativa en mención. Metodológicamente se ubica en el modelo de investigación “Sistematización de Experiencias”, entendido como un proceso hermenéutico, planeado y organizado, que recupera y reconstruye de forma lógica una experiencia significativa para entender por qué y cómo aconteció, qué enseñanza y qué de la experiencia es susceptible de ser replicada. Los sujetos participantes incluye 198 mujeres deportistas, con edades que oscilan entre los 13 y 59 años, 4 docentes de la upn y 12 monitores (estudiantes de la universidad pedagógica Nacional y líderes comunitarios). Los resultados sugieren que la sistematización de experiencia tiene un gran potencial para entender las iniciativas locales; que los eventos orientados a un sector en particular, no necesariamente significan una acción diferencial; y que el empoderamiento de la mujer debe seguirse fortaleciendo en sentidos prácticos y filosóficos superando su enfoque activista.
Nogo-A exacerbates sepsis-associated encephalopathy by modulating microglial SHP-2/NLRP3 balance and inducing ROS and M1 polarization
Authors: Liu Ying , Guo Lei , Zhang Guoan , Sun Wenjie , Yang Xiaohui , Liu Yingfu
Published: August 2024

Sepsis, a systemic inflammatory response caused by infection, can lead to sepsis-associated encephalopathy (SAE), characterized by brain dysfunction without direct central nervous system infection. The pathogenesis of SAE involves blood-brain barrier disruption, neuroinflammation and neuronal death, with neuroinflammation being the core process. Nogo-A, a neurite growth-inhibitory protein in the central nervous system, is not well understood in sepsis. This study explores Nogo-A's mechanisms in sepsis, focusing on SAE. Using in vivo and in vitro methods, healthy SPF C57BL/6J male mice were divided into Sham, Nogo-A-NC-Model, and Nogo-A-KD-Model groups, with sepsis induced by abdominal ligation and puncture. Morris water maze tests assessed learning and memory, and brain tissues underwent hematoxylin-eosin (HE) staining, Nissl staining, and Western blot analysis. In vitro, Nogo-A gene knockdown models were constructed using BV-2 microglia cells to study inflammation and oxidative stress. Results showed Nogo-A expression affected learning and memory in septic mice, with knockdown reducing neuronal damage. Bioinformatics analysis suggested Nogo-A may activate reactive oxygen species (ROS) to inhibit p-SHP2, activating mitochondrial autophagy and promoting neuronal apoptosis. Western blot results confirmed that Nogo-A affects mitochondrial autophagy and neuronal survival by inhibiting SHP2 and activating ROS. Nogo-A's role in neuroinflammation and neuroprotection was emphasized, revealing its impact on endoplasmic reticulum (ER) stress, mitochondrial autophagy, and NLRP3 inflammasome activation. This study provides a theoretical basis for SAE treatment, suggesting further multi-gene and multi-pathway analyses and validation in clinical samples. Developing gene therapy and drug interventions targeting Nogo-A pathways will offer more effective treatment strategies.
Publishing Generic Organ Scaffold as a SPARC Dataset v1
Authors: Lin Mabelle , Sorby Hugh
Published: August 2024

In this protocol, we will demonstrate how to prepare a generic organ scaffold for publication as a SPARC dataset using the Scaffold mapping tools. This protocol will ensure that a generic organ scaffold is made available and reusable to the community in a reproducible manner.
[RETRACTED] CrossRef Outage Prep, collection v1
Authors: Frolov Vladimir
Published: August 2024

[RETRACTED]

CrossRef Outage Prep collection
Culturing 3T3 Cells for Validating GEARBOCS 2.0 Constructs v1
Authors: T Savage Justin
Published: August 2024

This protocol is for culturing Cas9 NIH/3T3 cells for the validation of GEARBOCS 2.0 and similar constructs for use in in vivo assays.
The Influence of Cultural Capital on Students' Perceptions and Experiences of Hidden Curriculum
Authors: Aktaş Halil Han , Engin Cennet
Published: August 2024

This study investigates the perceptions and experiences of ninth-grade students concerning the hidden curriculum at a science high school in Ankara, focusing on how cultural capital influences its manifestation. A qualitative case study was employed, utilizing semi-structured interviews and observations. Throughout a 20-week period, 34 interviews were conducted with 17 purposively selected participants, one at the beginning and one at the end of the study, complemented by 10 days of observation over biweekly school visits. The collected data underwent content analysis, involving thorough reading, coding, and theme identification. The findings highlight that the cultural capital of students shaped their experiences and perceptions of the hidden curriculum, influencing their access to and use of social and material resources at school. Notably, students viewed their school primarily as a preparatory ground for exams rather than an institution aligned with the broader educational goals for science high schools. Additionally, the study observed differences in the experiences of boarder and extern students. The findings suggest that educators need to develop inclusive strategies that recognize and integrate students' varying cultural capital to foster a more emancipatory educational environment. Additionally, the study highlights the need for boarding schools to establish a participatory culture for extern students.
Determination of physicochemical and antioxidant properties of icecream produced with the addition of Jerusalem artichoke (Helianthus tuberosus L.)
Authors: Gündoğdu Engin
Published: August 2024

The study investigates the effects of incorporating Jerusalem artichoke (Helianthus tuberosus L.) into ice cream formulations on their physicochemical and antioxidant properties of icecream. Jerusalem artichoke, known for its high inulin content and beneficial carbohydrates, was added to ice cream in varying concentrations (5%, 10%, and 15%) and evaluated for its impact on dry matter, protein, ash, pH, acidity, sugar content, viscosity, volume increase, first dripping time, total melting time, color values, total phenolic content, DPPH free radical scavenging activity, and total antioxidant capacity.The results revealed that the addition of Jerusalem artichoke significantly improved the dry matter and antioxidant properties of the ice cream, with the highest values observed in samples containing 10% and 15% Jerusalem artichoke. The protein content decreased slightly with the addition of Jerusalem artichoke, while ash content increased. The pH and acidity values also showed significant changes, with higher concentrations of Jerusalem artichoke resulting in higher pH and acidity. Overall, the incorporation of Jerusalem artichoke into ice cream formulations enhances the nutritional and functional properties. These findings suggest that Jerusalem artichoke is a valuable ingredient for developing functional ice cream with potential health benefits.
Social Media and the Survival of Linear Television
Authors:   , Taveras Yisel , Tedesco Albert S. , McHugh Michelle
Published: August 2024

Linear television has had to adapt to swift changes in technology. No longer can television managers generate viewership as they used to, because of the influence of new competing technology and media platforms. This has been an increasing issue that has rapidly grown during the 2010's. With television platforms and streaming services such as Amazon, Hulu and Netflix proliferate, consumers demand their media consumption to be quicker and more convenient. This thesis provides a deep dive into how social media has grown to affect the way linear television can gain viewership and how advertisers are using this to their advantage as well.
Coronavirus Disease 2019 (COVID-19) Vaccination Status Prior to Delivery and Administration Among Hospitalized Obstetric Patients
Authors: Michelson Lisa P. , Beckham A. Jenna
Published: August 2024

Background

This chart review aimed to assess the COVID-19 vaccination status of pregnant patients prior to hospitalization for delivery and vaccine administration while hospitalized postpartum.

Methods

This was a retrospective chart review of pregnant patients admitted for delivery at WakeMed Hospital during a six-month period who were offered COVID-19 vaccination immediately following delivery. We analyzed demographic characteristics by vaccination status prior to admission, during hospitalization, and at discharge. ANOVA, chi-squared, and multinomial logistic regression analyses were performed.

Results

Data analysis was performed on 1,476 obstetric patients admitted for delivery, of which 260 (17.6%) were vaccinated prior to admission. Of the 1,216 unvaccinated postpartum patients, 257 (21.1%) received a vaccine dose. Among our population, for every year increase in age, the odds of being vaccinated before admission and receiving vaccination while hospitalized postpartum were higher than those of remaining unvaccinated. The odds of being vaccinated before admission versus remaining unvaccinated at discharge were lower for Black patients compared to White patients. The odds of receiving vaccination during hospitalization were higher for Asian and Hispanic/

Latino patients compared to White patients. The odds of being vaccinated prior to admission versus remaining unvaccinated at discharge were higher for those with private insurance compared to those with public insurance.

Limitations

At the time of our intervention, we did not collect data on COVID-19 infection status of the patient at the time of admission. Additionally, vaccination counseling and administration had not been added to standardized order sets, thus variations in counseling by providers may have impacted patient acceptance.

Conclusions

Compared to patients who remained unvaccinated following discharge, patients vaccinated prior to admission were more likely to be older with private insurance, and less likely to be Black, while patients vaccinated during hospitalization once postpartum were more likely to be older and either Asian or Hispanic/Latino.
Conventional all ceramic crowns versus CADCAM all ceramic laminates for esthetic rehabilitation of teeth with dental fluorosis: A 5 year follow-up study
Authors: Kapri Anita , Jacob Oliver , Rana Varun , Reddy Kiran , Kumari Pushpa , Rathi Akshi
Published: August 2024

Every individual wants to look good and have a pleasing smile. In this era of social media where each and every phase of one’s life is captured in camera, having an unpleasant smile makes a huge negative psychological impact on every individual. The foremost reason of an unesthetic smile commonly is dental fluorosis. Dental Fluorosis is an abnormality that causes enamel discolouration which may result when excess fluoride is consumed during the teeth forming stage i.e. 8 years and younger. The effect remains lifelong resulting in a huge esthetic insult. Treating such patients with aesthetic all ceramic crowns and veneers will definitely improve the patient’s self-esteem.

In this retrospective study we clinically evaluated the aesthetics and patient satisfaction of 2 different treatment modalities for dental fluorosis namely Conventional all ceramic crowns and CADCAM all ceramic laminates in teeth with anterior fluorosis. Patients were divided in two groups. Both the groups included 35 patients each, Group 1 received conventional all ceramic crowns (156 in anterior maxilla and 24 in anterior mandible) using IPS e max fabricated in porcelain furnace and Group 2 received CADCAM porcelain laminate veneers (144 in the anterior maxilla and 36 in the mandible) fabricated with incisal overlap technique that covered the incisal edge and part of the palatal/lingual side of the tooth with a 1 mm high palatal bevel. The Orofacial Aesthetic Scale (OES) was used to assess the overall satisfaction level and White Aesthetic Score was used to assess the overall aesthetic improvement post treatment in both the groups.

On the basis of the OES, it was found that CADCAM all ceramic laminates was more satisfying treatment for the patient rather than more extensive conventional all ceramic crown preparation. WES scores suggest that conventional all ceramic crown gives more aesthetic results as compared to CADCAM all ceramic laminates in moderate fluorosis.

The results of this clinical study should encourage clinicians to consider CADCAM all ceramic veneers over Conventional all ceramic crown restorations when restoring the smile of patients with moderate fluorosis.
Comparative evaluation of the fracture resistance of different core build up materials – An ex vivo study
Authors: Rajput Renu , Singh Anshdeep , Gupta Pulkit , Dhingra Anil , Dixit Seema , Grover Sheetal
Published: August 2024

The aim of this study was to evaluate and compare the fracture resistance of ParaCore, luxacore, multicore in permanent anterior teeth using universal testing machine.

Eighty recently extracted intact caries free Human Permanent Mandibular Premolars and disinfected according to CDC guidelines on infection control in dental health-care setting 2003. The teeth were then randomly assigned to four groups on the basis of material used (Group A – Multicore, Group B – Luxacore, Group C – Paracore, and Group D – control group, without any core buid up), each group consisting of 20 samples. The dentin surface was treated with the respective adhesives of the groups and then bulk filled with core build-up materials. The attained samples were than subjected to shear loading in Instron Universal Testing Machine. The data were tabulated and statistically analyzed using analysis of variance, Tukey’s HSD test.

MultiCore material had the greatest fracture resistance followed by Group B and then group C. The least strength exhibited was by Group D – Control group preceded by Group A – ParaCore.

MultiCore showed the highest fracture resistance followed by Luxacore, ParaCore, and control group
Finger prosthesis: Uplifting life, one finger at a time
Authors: CK Anulekha , D.N.S Sravya , Aligapally Haripriya , Kondareddy Sreedevi , Pasham Shilpa , Kakarlapudi Akhila Devi
Published: August 2024

Partial or complete loss of fingers is frequently encountered in cases of partial hand injuries, representing a prevalent occurrence. While traumatic events are a common cause of finger amputations, congenital malformations and diseases can also contribute to digit loss, thereby widening the spectrum of potential etiologies. Irrespective of the underlying cause, the absence of a finger poses significant challenges, affecting both the functionality and psychological well-being of individuals. Consequently, addressing these challenges becomes paramount, prompting the fabrication of partial or complete finger prostheses as a viable solution to alleviate the associated functional and psychological impacts.
Skills for Life Series: Resilience
Authors: Suarez Enciso Sonia , Yang Hyeri Mel , Chacon Ugarte Gabriela
Published: August 2024

Resilience, the ability to recover positively from stress or trauma, is essential for personal development and well-being. It is linked to socioemotional skills and social relationships, such as family and friends. Resilience development can begin in early childhood through adulthood through age-specific activities and routines. In this brief, we introduce more about its relevance, as well as successful initiatives to foster these skills and the existing tools to measure them.
Gender and racial differences in the earnings penalty of working from home before and during the COVID-19 pandemic
Authors: Maia Alexandre Gori , Lu Yao
Published: August 2024

We investigate differences in earnings penalties associated with working from home (WFH) between groups of gender and race before and during the COVID-19 pandemic in Brazil. Using a large and nationally representative longitudinal dataset, we show that the earnings penalty associated with WFH diminished for White and Black men during the pandemic while remaining high for White and Black women. We further examine three mechanisms explaining these changes: i) the equilibrium between supply and demand, as more women than men transitioned to WFH during the pandemic; ii) labor productivity, as the effective working hours of Black women were more affected by WFH; and ii) visibility and promotion, as White women became less likely than White men to be promoted when WFH during the pandemic.
Assessing Pulmonary Function in Workers Exposed to Rice Threshing Processes
Authors: Rath Ipsita , Mishra Jayanarayan , Verma Kumudini , Pradhan Abhishek , Pani Pralipta
Published: August 2024

The economic significance of rice cultivation in India is vast, spanning diverse agro-climatic zones. Threshing, a crucial aspect of rice farming traditionally involves manual or motor-operated methods. Despite the prevalent adoption of tractoroperated axial flow threshers, the process remains inherently dusty, predominantly comprising organic dust particles, posing a substantial health risk to workers. This study aims to evaluate and compare the lung functions of individuals exposed to rice dust with an unexposed control group, while investigating the correlation between the duration of exposure in threshing operations and observed respiratory parameters. Thirty agricultural workers aged 30-45, with varying threshing experience (3, 5, and 7 years), were selected alongside thirty non-agricultural workers for Pulmonary Function Tests (PFT), including Forced Vital Capacity (FVC) and Forced Expiratory Volume in 1 second (FEV1). Spirometry, a vital diagnostic tool for occupational respiratory diseases was utilised to measure dynamic lung functions. The findings revealed relatively constant FVC values with increasing years of experience, while both FEV1 and FEV1/FVC values demonstrated a decline with prolonged exposure, indicating an escalated susceptibility to obstructive lung diseases such as asthma, emphysema, chronic bronchitis and bronchiectasis among workers in this occupation.
Pharmacoeconomics of Apixaban against Warfarin – A Review
Authors: Alnakhli Hussam Abdullah , Raju Akondi Butchi , Kayamkani Abedulla Khan
Published: August 2024

Atrial fibrillation, an irregular heartbeat, is a risk factor for various heart-related complications. Its prevalence increases with age and is expected to rise dramatically by 2030. Warfarin is traditionally prescribed to prevent strokes in atrial fibrillation patients, although it has its limits. Apixaban, a newer oral antithrombotic therapy, is effective in reducing strokes and bleeding. Several studies have examined the cost-effectiveness or value for money of Apixaban compared to Warfarin in different countries. In a study conducted in Japan, Apixaban was found to reduce strokes and bleeding events, leading to improved life years gained. Apixaban’s total cost per patient was higher, but it was still considered cost-effective. In a study from China, Apixaban also reduced strokes and bleeding compared to Warfarin. The expected life-years gained and quality-adjusted life-years gained were slightly lower compared to the Japanese study, but apixaban was still considered cost-effective. A study from Argentina showed similar results, with Apixaban reducing strokes and bleeding. The cost of Apixaban was higher than Warfarin, but Apixaban was still considered cost-effective based on incremental value-formoney ratios. Overall, the trials show that Apixaban offers better value for money than Warfarin for stroke prevention in atrial fibrillation patients. However, there were variations in the specific outcomes and costs among the countries studied. In Japan, the cost of Apixaban was higher and the life-years gained were greater compared to China and Argentina. Despite these variations, all three studies supported the fact that Apixaban was more value for money as compared to Warfarin.