bluuebunny/crossref_metadata_2025 huggingface dataset:
Relações Espaciais, Temporais e de Ordem para Detecção de Colisão Broad Phase Genérica e Escalável
Authors: Serpa Ygor Rebouças , Rodrigues Maria Andréia Formico
Published: February 2021

Simulações físicas são fundamentais para a representação computacional de situações do mundo real. Neste contexto, a detecção de colisões entre objetos 3D é crucial, uma vez que provê a ilusão de que estes são sólidos, porém, não há uma solução simultaneamente capaz de eficientemente atuar genericamente e escalar de maneira competitiva. Este trabalho apresenta e valida uma nova solução otimizada para a detecção de colisão broad phase que preenche esta lacuna, a qual é baseada em uma associação entre a KD-Tree e as técnicas Sweep-and-Prune e incremental. A solução obteve resultados duas a três vezes melhores que as demais soluções do estado-da-arte, sendo robusta a variações de comportamento, tamanho e distribuição dos objetos. Além disso, mostrou-se capaz de atuar eficientemente em todos os cenários testados e escalar em ambientes com até um milhão de objetos.
Controle de Acesso Baseado em Papéis em Ambientes Assistidos
Authors: Goulart Gabriel Rosa , Dantas Mario A. R.
Published: February 2021

Este trabalho apresenta um sistema de controle de acesso baseado empapéis de usuário e ambiente, utilizando informações de contexto para comporas regras de acessos. Para validar o funcionamento desse sistema, 4 indivı́duosde diferentes faixas etárias realizaram testes durante o perı́odo de duas sema-nas em um ambiente assistido domiciliar, onde tags RFID foram utilizadas paraidentificar os usuários de maneira não intrusiva. Após os testes, identificou-seque todas as tentativas de acesso foram processadas corretamente, independen-temente das mudanças dos papéis ou das regras de acesso, o que mostra que osistema proposto de fato funciona em um ambiente assistido.
Sistema de recomendação baseado no modelo de reconhecimento de atividades HARA
Authors: Silva Gabriel Di iorio , Stroele Victor , Dantas Mario
Published: February 2021

Formas de se monitorar continuamente a saúde humana vem se tornando populares, principalmente devido ao alargamento de nossa pirâmide etária. Nesse cenário ambientes assistidos surgem como uma tecnologia para atender às necessidades desse público alvo. Técnicas que detectam as atividades realizadas por um indivíduo se mostram promissoras para esse problema uma uma vez que ao se identificar as ações podemos perceber anomalias na rotina de um usuário que podem sinalizar estágios iniciais de uma doença. Sistemas de recomendação surgem como uma maneira de agregar funcionalidades à ambientes assistidos com o intuito de realizar recomendações para o usuário final ou o especialista médico de acordo com a gravidade notada da anomalia. Estudos iniciais mostram que a proposta de mesclar sistemas de recomendação com ambientes assistidos é viável e diferencial dado que essa junção é pouco explorada
Reconstrução 3D de Objetos com Kinect e Câmera Digital
Authors: Loura Daniel de Sousa Alves , Oliveira Yuri de Matos Alves de , Raimundo Pedro Oliveira , Agüero Karl Philips Apaza
Published: February 2021

Objetos com áreas superficiais complexas e detalhes de reprodução manual impraticável em software de Computer Aided Design (CAD) são os principais alvos dos processos de escaneamento e reconstrução 3D. Neste trabalho, foi concebido um método para a reconstrução e geração de modelos 3D. Informações de geometria e cor de objetos reais foram respectivamente capturadas por um sensor de profundidade Microsoft Kinect 360 e uma câmera digital de alta qualidade, objetivando um processo de baixo custo. Apresenta a metodologia, equipamentos, processos e resultados iniciais da reconstrução 3D de objetos culturais importantes do Museu de Arqueologia e Etnologia (MAE) da UFBA.
Deconsolidation and de-democratisation: Current western Balkans experience of the transition
Authors: Solioz Christophe
Published: February 2021

This article reviews the third decade of the post-Wall transition of central and eastern Europe, paying particular attention to the western Balkans. It focuses on European integration and the indicators of deconsolidation - notably, the lack of trust which has characterised the ‘crisis of confidence’ induced by the EU’s own series of crises since the middle of the 2000s. Additionally, the rise of authoritarianism and populism across the region is often viewed as a symptom of a possible ‘de-democratisation’, or reverse wave. From a process-oriented perspective, the author suggests a rethinking of the various polarisations under which, instead of seeing democratisation and de-democratisation as opposing forces, we may recognise instead that both are actually continuous, interconnected processes related to democracy itself - and not (at least, not necessarily) to a growing state of non-democracy. Oscillation between these two states may well characterise the next decade of the transition but, if we are to address the problems that this causes, we must first understand precisely how we have got where we are.
El problema de la reflexión en Husserl y Heidegger
Authors: Adrián Escudero Jesús
Published: February 2021

La idea de que la fenomenología de Husserl representa una suerte de filosofía reflexiva, basada en una metodología que desarrolla la tradición cartesiana, se ha convertido en una creencia ampliamente difundida en la literatura filosófica. Este énfasis puesto por Husserl en la reflexión fue arduamente criticado por Heidegger. Desde entonces resulta frecuente encontrarse con la afirmación de que Husserl y Heidegger desarrollan dos conceptos de fe-nomenología diferentes, incluso antagónicos. No se trata de seguir alimentando esta discusión historiográfica. Aquí, por una parte, se muestra el núcleo de la temprana crítica heideggeriana en el transcurso de sus primeras lecciones de Friburgo (1919-1923) y Marburgo (1924-1928) y, por otra, se sopesan algunas de las observaciones críticas de Heidegger a Husserl a la luz de evidencias textuales de la fenomenología husserliana, ignoradas no sólo por Heidegger, sino también por un sorprendente número de reconocidos especialistas en el campo de la filosofía, de las ciencias cognitivas y de la filosofía de la mente.The idea that Husserl’s phenomenology is a kind of reflective philosophy inspired by the Cartesian tradition has become a common-place in the philosophical literature. Heidegger was one of the first thinkers who criticized the Husserlian emphasis on reflection. Since then it is easy to find the affirmation that Husserl and Heidegger developed two different, even antagonistic concepts of phenomenology. Here is not the place to continue embracing this discussion. One the one hand, the present article shows Heidegger’s early criticism developed in the course of his first lectures in Freiburg (1919-1923) and Marburg (1924-1928). On the other hand, it weighs up some of Heidegger’s critical remarks regarding the reflective nature of Husserlian phenomenology in the light of important textual evidences ignored not only by Heidegger, but also by a surprising number of specialists in the fields of philosophy, cognitive sciences, and philosophy of mind.
Juguemos a "Ideas" en tiempos de crisis. Una filosofía democrática para una democracia filosófica
Authors: García Querol Ferrán
Published: February 2021

Nos preguntamos qué puede aportarnos Ideas ante la actual crisis de la filosofía, la cual tiene que ver con el derrumbamiento de las viejas estructuras de poder en España y en Europa. Para ello, exponemos el sentido originario del proyecto tal como Husserl lo formula en el epílogo y en la introducción de la obra. Ahí nos damos cuenta de la diferencia que hay entre su ideal filosófico-fenomenológico, que es transdisciplinar, y el nuestro, que ha sido reducido a una disciplina especializada. Uno parte de la experiencia en primera persona y aspira al libre entendimiento mutuo entre expertos y profanos; el otro parte del texto como presupuesto y supone una cierta relación jerárquica entre expertos y profanos. Finalmente, partiendo de la praxis fenomenológica que el mismo Husserl lleva a cabo en numerosos pasajes de Ideas I, caracterizamos un paradigma filosófico democrático, acorde con las necesidades de nuestro tiempo.We wonder what can bring Ideas to the current crisis of philosophy, which has to do with the collapse of the old power structures in Spain and Europe. Therefore, we expose the original sense of the project as it is formulated in the epilogue and in the introduction of this book. Then, we realize the difference between the original philosophical-phenomenological ideal, which is transdisciplinary, and ours own ideal, which has been reduced to a specialized discipline. One starts from the first person experience, and aspires to a free mutual understanding between experts and lay people; the other starts from the text, and presupposes a certain hierarchy between experts and laymen. Finally, we base on the phenomenological praxis which Husserl performed in numerous passages of Ideas I, and we characterize a democratic philosophical paradigm, according to the needs of our time.
Realidades múltiples y ámbitos finitos de sentido (de W. James a A. Schütz) a la luz del proyecto fenomenológico-trascendental de "Ideas I"
Authors: De Mingo Rodríguez Alicia María
Published: February 2021

Aunque inicialmente la propuesta de A. Schütz resulta esclarecedora y sugerente, sin embargo, al proponer hablar de ámbitos finitos de sentido en lugar de realidades múltiples (W. James), se puede encubrir una posibilidad de mala interpretación del proyecto trascendental de la fenomenología. Ello estaría en función de la gran importancia que detenta en Schütz no sólo la actitud natural, sino el mundo de la “realidad práctica”. Me propongo plantear esta problemática a la luz del proyecto husserliano de fenomenología trascendental presentado en Ideen I.Although initially the proposal of A. Schütz is enlightening and suggestive, nevertheless, on having proposed to speak about finite provinces of meaning instead of multiple realities (W. James), it is possible to conceal a possibility of bad interpretation of the transcendental project of Phenomenology. It would be depending on the great importance that holds in Schütz not only the natural attitude, but the world of the “practical reality”. I intend to raise this issue in the light of Husserls transcendental phenomenology project presented in Ideen I.
Aproximación hermenéutico-crítica a la fenomenología de la razón en Ideas I
Authors: Quesada Balbino A.
Published: February 2021

La fenomenología de la razón escudriña todos los procesos racionales que intervienen en la aprehensión del objeto real y de su constitución, y las consiguientes relaciones noético-noemáticas. Sólo la razón pura colegida, primero como fuerza que depura los procesos de la evidencia y las posiciones del sujeto, y sólo la razón entendida también como proceso que ratifica la verificabilidad del darse el objeto y de todos los demás procesos y relaciones, se revela como la única instancia posible capaz de asegurar la validez del conocimiento y del objeto del conocimiento. Por otro lado, la razón juega un papel decisivo en lo que respecta al sujeto de razón. Ésta es la nota constitutiva y respectiva del ser humano, el poder que lo separa del entramado de facticidades y contingencias de las que se compone la realidad, de suerte que éste no es un factum más entre todas las objetividades, tal como postulan la psicología y las ciencias naturales. El hombre es un ser mundano, está efectivamente en el mundo. Ahora bien, “su ser en” y “su estar en” son modificados por el poder de la razón. Su modo de ser mundano es serlo racionalmente. Únicamente de este modo el Umwelt deviene Lebenswelt.The phenomenology of reason inspects all rational processes involved (which participate) in the apprehension of real object and its constitution, and the respective noetic-noematic relationships. Only the pure reason comprehended, first of all, as a strength which purifies the mentioned processes, the evidence and the subject positions. Secondly the reason, also comprehended as a process which confirms the object verificability which gives itself and the other processes and relationships, appears as the only possible power, which is able to guarantee the validity of the knowledge, and so the object of knowledge. On the other hand, the reason plays a very important role in the subject of the reason. This is the constitutive and respective note of the human being, the power (strength) that separates it from the labyrinth of facts and contingencies which makes up reality, so that this (human being) isn’t a fact among all objectivities, as postulated by psychology and natural sciences. The human being is a worldly being; he is really in the world. Now then, “his being-in” and “his staying-in” are modified by the strength of the reason. His way of being worldly is being rationaly. Only in this way the “Umwelt” becomes “Lebenswelt”.
Heidegger o la metódica "destrucción" dentro de la fenomenología husserliana
Authors: Velázquez González Juan
Published: February 2021

Es dentro del marco de la fenomenología de Husserl donde Heidegger lleva a cabo su propuesta filosófica, que implica una “destrucción” o “desmontaje” de los conceptos de la tradición, comenzando por los de la fenomenología de su maestro, y una construcción de su propio proyecto filosófico, basado en una analítica de la existencia.La “destrucción” es prácticamente elevada por Heidegger al rango de método filosófico, en paralelo pero en sentido contrario a la epoché, el método fenomenológico de Husserl. Esta diferencia de método, respecto a una común consideración de la intencionalidad de la conciencia, separa los proyectos fenomenológicos del Husserl de Ideen I y del Heidegger de Sein und Zeit: eidético u ontológico. A partir de su método destructivo Heidegger radicalizará las nociones de la fenomenología de Husserl.Within the framework of the phenomenology of Husserl, Heidegger carries out a double philosophical proposal: the “destruction” or “dismantling” of the concepts from the tradition, beginning with those ones of the phenomenology of his teacher, and the construction of his own philosophical project, based on an analysis of the existence.The “destruction” is practically considered by Heidegger as a philosophical method, which is developed in parallel but in a contrary direction to the phenomenological method of Husserl: the epoché. This methodological difference, applied to the intentionality of the consciousness, that the two philosophers consider, separates the phenomenological projects of Husserl in Ideen I and Heidegger in Sein und Zeit: eidetic or ontological. So and from his destructive method Heidegger is going to radicalize the main notions of the phenomenology of Husserl.
Consideraciones acaso intempestivas acerca de la traducción de la fenomenología husserliana en ocasión de la nueva versión de "Ideas I" en español
Authors: Zirión Quijano Antonio
Published: February 2021

Con ocasión de la reciente publicación (agosto de 2013) de la nueva edición de la traducción de José Gaos del Libro primero de las Ideas de Husserl, refundida integralmente por el autor, se presentan en este texto unas reflexiones acerca de las principales características y los principales problemas de la nueva versión, y se pone la obra, y el trabajo de traducir la obra de Husserl en general, en el contexto del desarrollo del pensamiento fenomenológico en lengua española. El texto convoca a una traducción de Husserl hecha en colaboración, al menos con respecto a la formación de un acervo acordado de términos técnicos que efectivamente sirva a ese desarrollo.On the opportunity of the recent publication (August, 2013) of the new edition of the translation of José Gaos of the First Book of Husserl’s Ideas, completely reworkes by the author, the text presents some reflections about the main features and the main problems of this new version, and the work, and the task of translating the work of Husserl in general, is put in the context of the development of the phenomenological thinking in Spanish language. The text invites to a translation of Husserl made in collaboration, at least with respect to the creation of an agreed corpus of technical terms that might efectively promote that development.
Accounting for a riot: Religious identity, denying one's prejudice, and the tool of blasphemy
Authors: Putra Idhamsyah Eka , Wagner Wolfgang , Holtz Peter , Rufaedah Any
Published: February 2021

This paper presents an analysis of interviews of participants in a political manifestation in Indonesia about the reasons for the rally and the resulting riot. The rally was held in the middle of the Jakarta gubernatorial election, against a non-Muslim incumbent who was accused of having insulted the Quran. We argue that there is a deep relationship between social identities and religion, which has implications for societal togetherness and political freedom. Using a snowball technique, we interviewed 16 Muslims who had participated in this rally. The findings suggest that 1) even though the rally was held in the middle of an election, the demonstrators denied that the rally was politically motivated; 2) Those demonstrators who thought that intruders had infiltrated the rally, maintained that the intruders are to be held responsible for any violence, but not the ‘actual’ participants. 3) Interviewees claimed that their actions were not motivated by anti-Chinese prejudice, although traces of racist thinking can be found in their statements. The findings are discussed before the background of social representations, social identity, theories of collective action, and the black sheep effect.
Moda para meninas adolescentes:
Authors: Pereira Tais Oliveira Ventura , Cipiniuk Alberto , Santos Irina Aragão dos
Published: February 2021

O presente artigo reflete sobre a produção de peças de vestuário para adolescentes com obesidade mórbida de 12 a 14 anos, tendo em vista o número crescente de usuários na condição de excesso de peso e a forma como as marcas elaboram seus produtos de moda. O objetivo é ampliar o debate sobre os padrões de beleza do mercado, refletir sobre a práxis do designer, além de indagar se o vestuário oferecido atende às adolescentes em questão. O método utilizado foi revisão bibliográfica, levantamento de lojas do setor, aplicação de questionários às meninas estudadas e aos seus responsáveis, além de entrevistas com os profissionais responsáveis pelo atendimento médico delas no Hospital Pedro Ernesto, localizado em Vila Isabel, campo escolhido por reunir maior número de adolescentes em situação de obesidade. Para entender o mercado de moda, realizamos entrevista com a dona de uma marca carioca de moda feminina infantojuvenil estabelecendo um paralelo com outra marca do setor feminino, encerrando com uma reflexão acerca da prática profissional do Designer dentro do modo de produção capitalista, e a atividade laboral de desenhar roupas para os usuários. A pesquisa é relevante por convidar os pares a refletir sobre os padrões estabelecidos de beleza e de produção, que materializados na forma como estão elaborando os produtos de vestuário, de acordo com as condições materiais de produção não atendem as usuárias em questão.
RELATO DE EXPERIÊNCIA NA CAPACITAÇÃO EM ATENDIMENTO ODONTOLÓGICO DE URGÊNCIA E EMERGÊNCIA
Authors: Franciscatto Gisele Jung
Published: February 2021

Esse artigo apresenta o relato de experiência a respeito do projeto de Capacitação em Atendimento Odontológico de Urgência e Emergência na Universidade Federal de Santa Maria. O tratamento de urgência e emergência pode ser descrito como a abordagem inicial de um paciente que se encontra em situação de dor ou anormalidade, abrangendo afecções pulpares, periapicais, periodontais ou traumáticas, necessitando intervenções clínicas e/ou cirúrgicas. Esses atendimentos fazem parte da rotina do cirurgião-dentista, logo, o projeto surgiu com o objetivo de capacitar alunos do Curso de Odontologia que têm pouca experiência e contato durante a graduação com tais procedimentos. O projeto também tem objetivo de ofertar à população, que busca atendimento nas clínicas da Universidade, uma opção de um serviço destinado exclusivamente para esses atendimentos, visto que são poucas vagas ofertadas pelas clínicas usuais da graduação. Com início em março de 2017, funcionando em dois turnos semanais, conta com alunos de graduação, professores, uma odontóloga e alunos de pós-graduação. O atendimento de urgência busca, principalmente, o alívio da dor, eliminando imediatamente sua causa, e restauração da função dentária e encaminhamento do paciente para realização do tratamento odontológico definitivo adequado. Até dezembro de 2017, com cerca de 10 meses de projeto, aproximadamente 80 pacientes receberam atendimento, obtendo suas queixas sanadas e sendo acolhidos pela Universidade. Cerca de 77% dos atendimentos envolveram alguma intervenção endodôntica.
A IMPORTÂNCIA DA CONSCIENTIZAÇÃO DO CONSUMIDOR SOBRE TERMOS ALIMENTARES: Projeto de extensão com alunos do ensino fundamental
Authors: Costa Jennifer Lima , Santos Tayna Jamille , Santos Patrícia Natalina , Souza Raquel Lucena , Torres Filho Robledo de Almeida , Da Silva Vanelle Maria , Carvalho Naiara Barbosa
Published: February 2021

Esse estudo é baseado no projeto de extensão “Terminologias aplicadas em alimentos: conscientização do consumidor para a sua autonomia no momento da compra”, em que o objetivo foi compreender e conscientizar os alunos do ensino fundamental de uma Escola Estadual de Florestal - MG, sobre os termos diet, light, probiótico, prebiótico, irradiado e transgênico. Os temas foram apresentados por meio de palestras e atividades dinâmicas em seis encontros. No primeiro encontro, foi aplicado aos alunos um questionário contendo questões objetivas sobre o significado de cada tema citado acima e outro questionário, elaborado com questões sociodemográficas, de hábitos de consumo e de possíveis doenças na família relacionadas com os mesmos termos, foi entregue para os alunos responderem com o auxílio dos pais em suas casas. O questionário para os alunos foi novamente aplicado após os encontros a fim de avaliar se houve alteração no índice de acertos após as explicações. Posteriormente, foram realizadas três palestras sobre, respectivamente, os temas probiótico e prebiótico, diet e light, e transgênico e irradiado, com a apresentação de cada tema contendo exemplos de alimentos, os benefícios que proporcionam à saúde, definições e o modo de consumo. Ao final de cada palestra era realizado um jogo de perguntas relacionado às definições do tema abordado. Inicialmente, os índices de acerto foram: o probiótico (31%), seguido por prebiótico e o irradiado (45%), o light (56%), o transgênico (58%), e, por último, o diet (97%). No questionário final, os índices de acertos foram: light (71%), irradiado (63%), probiótico (60%), transgênico (56%), prebiótico (40%) e diet (39%), sendo que o termo light obteve o maior índice de acertos. Isso demonstra que os alunos entenderam os termos, sabiam explicar seus significados e dar exemplos de alimentos. Desse modo, observou-se que os jovens agregaram conhecimento sobre os termos técnicos e símbolos atuais que se encontram presentes nos rótulos de produtos alimentícios e, logo, estão mais conscientes do consumo desses alimentos. Para a equipe do Projeto, o mesmo foi de muita valia, tanto para a bolsista quanto para as voluntárias, pois apesar das dificuldades encontradas no desenvolvimento do trabalho, o mesmo contribuiu para agregar conhecimento e auxiliar na formação acadêmica e pessoal das discentes.
Influence of different repair protocols and artificial aging on bond strength of composite to a CAD/CAM polymer-infiltrated ceramic
Authors: OĞUZ Ece İrem , ÇİÇEKCİ Gökhan
Published: February 2021

Abstract
Objectives: The repair bond strength of the composite to a polymer-infiltrated ceramic network (PICN) restoration may vary depending on the repair protocol used and may decrease over time. The aim of this study was to evaluate the effects of different repair protocols and artificial aging on shear bond strength (SBS) of a composite for repair to PICN material.
Materials and methods: Artificially aged specimens (5000 thermal cycles between 5°C and 55°C) sliced from PICN CAD/CAM blocks (Vita Enamic) were randomly divided into 5 groups according to the repair protocol applied: 1) TS: tribochemical silica coating-Single Bond Universal 2) ES: etching with hydrofluoric acid (HF)-Single Bond Universal 3) EU: etching with HF-Ultradent Porcelain Repair System 4) GU: grinding with diamond bur-Ultradent Porcelain Repair System 5) GI: grinding with diamond bur-Ivoclar Vivadent Ceramic Repair System. After receiving a composite resin cylinder for repair, specimens were further divided into 2 subgroups considering artificial aging procedure (n=12): baseline/aging (5000 thermal cycles between 5°C and 55°C). SBS tests were performed by using a universal testing machine and failure types were classified as cohesive failure in PICN, cohesive failure in composite, adhesive, and mixed. The SBS data were analyzed with 1-way ANOVA,factorial ANOVA, least signifigance difference, and Duncan tests (α=0.05). Failure modes were calculated as a percentage.
Results: The mean SBSs for ES and GU were higher than TS at baseline (p<0.05). After aging procedure, EU and GU showed lower SBS than ES (p<0.05). Aging decreased the SBS for ES, EU and GU compared to baseline (p<0.05). The failure modes in general were observed as cohesive in PICN at baseline, while the only group that showed cohesive failure predominantly was EU after aging.
Conclusions: Considering the time-efficiency and effectiveness, etching with HF followed by Single Bond Universal application can be recommended as the intraoral repair protocol for PICN.
Precursor emblemático
Authors: Lalueza Ferran
Published: February 2021

COMeIN no podría soñar con mejor padrino para el lanzamiento de su primer libro recopilatorio que Pere Portabella: cineasta de culto, político, tertuliano, director teatral, artífice de un longevo evento político-social de obligada referencia estival (su legendario suquet) y, en definitiva, incomparable agitador. Hoy preside el patronato de uno de los principales think tanks españoles, la Fundación Alternativas. Y hace exactamente 40 años, orquestó la puesta en escena de una operación de Estado que marcaría el devenir de Cataluña.
Barcelona, ciudad de eventos
Authors: Estanyol i Casals Elisenda
Published: February 2021

Barcelona es una de las primeras ciudades a nivel mundial en acoger un gran número de congresos y eventos internacionales. Eventos que, a su vez, ayudan a construir y transformar su posicionamiento. El place branding se consolida como especialidad ligada al marketing pero que necesita también de estrategias y técnicas propias de las relaciones públicas.
Llega FilminCAT: el portal de vídeo bajo demanda de cine y series en catalán
Authors: Clares Gavilán Judith
Published: February 2021

Coincidiendo con la celebración del décimo aniversario de Filmin, el viernes 2 de junio llegó FilminCAT, la primera plataforma de vídeo bajo demanda de cine y series íntegramente en catalán accesible desde España y Andorra.
Ayurvedic Management of Subepithelial Vocal Cord Cyst: A Case Study
Authors: Raman Sundara , Krishna S Aswathy , Ashwini BN , Sivabalaji K
Published: February 2021

Vocal fold cysts, otherwise called as vocal cord cyst, are benign masses formed on the membranous vocal folds. Present line of treatment in contemporary medical science is surgery followed by supplementary voice therapy. There are high chances of recurrence of the cyst after surgical excision. This report deals with a single case which was effectively managed with ayurvedic intervention. A 38-year-old female patient presented with hoarseness of voice, difficulty to produce high pitch notes, variations in pitch while talking. Rigid endoscopy was done and there was presence of solitary subepithelial vocal fold cyst in the middle of larynx. Treatment was done with Amapachana with Swasamrutam capsule and gorochanadi, two tablets twice daily after food. Snehapana with Varanadighrita + Guggulutikthaka ghrita in arohana matra for 4 days; Abhyanga and bashpasweda for 1 day; Virechana with TrivrtChurna 20 gm given at 7 am; Nasya with Anuthaila for 7 days; Matravasti with Sahacharadi Mezhukupakam 60 mL for 5 days. The hoarseness of voice and voice clarity improved on completion of the treatment. A repeat endoscopy showed that the cyst was no longer present. Subepithelial vocal cord cyst can be effectively managed with ayurvedic intervention principles of amapachana, agnideepana and ojovardhana.
An Observational Study of Stroke and its Outcomes in a Tertiary Care Hospital
Authors: Gujjar Amruth , Walwekar Rekha , Dattatri AN
Published: February 2021

Introduction: Incidence of stroke is higher in developing countries than in developed countries. India shows prevalence of Cerebrovascular Disease (CVD) in the range of 52 to 843/100,000 population. Stroke causes 9% deaths around the world. The basic principle of managing stroke includes making an accurate diagnosis, choosing the effective drugs and dose for the stroke type. Aim: To analyse the outcomes of pharmacotherapy of stroke based on characteristics and clinical presentation of patients admitted to hospital and to know the adverse effect of drugs used. Materials and Methods: This cohort study was conducted with Department of Medicine and Neurology at Karnataka Institute of Medical Sciences, Hubballi from January 2015 to December 2015. After clearance from Institutional Ethics Committee, 162 cases were selected based on the inclusion and exclusion criteria. The clinical history, in examination modified Rankin score (mRS) at admission, discharge and on follow-up were recorded. The criteria for selecting the drugs, frequency, dosing, duration and change in drug therapy were recorded. The efficacy of drug therapy was assessed by clinical improvement. The adverse events were assessed and recorded. The patients were followed-up at three and six months. The data were entered after defining the variables in SPSS (version 16) from case record form. Descriptive statistics were used to summarise baseline data. Results: Of the 162 patients, 155 completed the six months follow-up. The median age of patients was 60 years for ischaemic and 55 years for haemorrhagic stroke. More males were admitted with strokes {108 (69.67%)} compared to females {47 (30.32%)}; 130 (83.87%) patients had ischaemic strokes, 16 (10.30%) haemorrhagic stroke {15 (9.67%) were intracerebral haemorrhage + 1 (0.63 %) patient had a subarachnoid haemorrhage}, 9 (5.8%) had Transient Ischaemic Attack (TIA). The modified Rankin score calculated for the patients was statistically significant between admission and discharge (1.29, p-value 0.0035), and that between three months and six months (0.9, p-value 0.003) of follow-up.Total 93% of 121 patients with ischaemic stroke received antiplatelet therapy. Amlodipine was the most commonly prescribed antihypertensive. Conclusion: Pharmacotherapy of stroke in the study was evidence-based and satisfactory. However, patients showed reduced compliance to all medications. Clinical presentation and type of stroke were important predictors of morbidity and mortality at the end of six months.
Prospective Study on Histopathological Spectrum of Upper Gastrointestinal Tract Lesions in a Teaching Hospital of Southern India
Authors: Aruna Eslavath , Chakravarthy V Kalyan
Published: February 2021

Introduction: The Upper Gastrointestinal Tract (UGIT) disorders are quite common in routine clinical practice and have high degree of morbidity and mortality. They can be studied by collecting tissue sample by way of fiberoptic endoscope and by subjecting the tissue to histopathological examination. Aim: To study the spectrum of histopathological lesions of UGIT lesions by endoscopy. Materials and Methods: This was a prospective observational study done in the Department of Pathology at PSIMS, Chinna Avutapalli, Andhra Pradesh, India, over a period of one year from March 2019 to February 2020 on 160 endoscopic biopsies. All UGIT endoscopic biopsies received were examined histopathologically. The data was entered into excel sheets and percentages and ratios were calculated. Results: Lesions of UGIT were more common in the age groups of 31 to 50 years and the male to female ratio was 1.9:1. The patient age ranged from 20 years to 78 years. Stomach was the common site for UGIT endoscopic biopsies i.e., 80 (50%) followed by oesophagus 50 (31.2%) and then duodenum 30 (18.7%). At all three sites, non-neoplastic lesions predominated over neoplastic lesions. The gastric malignancies were more common in antral and pyloric regions. Conclusion: Males in the fourth and fifth decades are more prone for UGIT lesions with predominance of chronic non-specific inflammatory conditions as compared to neoplastic conditions. Malignancy within the stomach, more commonly affects the antrum and pylorus. Malignant lesions are very rare in duodenum.
A Study of Significance of Poorly Differentiated Clusters in Colorectal Carcinomas: Association with Histopathological Prognostic Factors
Authors: Maurya Shailja , Patel Sapna , Srikantegowda Harish
Published: February 2021

Introduction: Colorectal Cancer (CRC) is the third most common cancer worldwide with prevalence rate of 47 million per five years and 1.8 million new cases per year. Routinely differentiation-based histologic grading of CRC is used, but its clinical impact is limited by insufficient prognostic value, inter-observer variability and the difficulty of its application to specific CRC’s like mucinous, micropapillary, signet ring cell and medullary carcinomas. To overcome this, Poorly Differentiated Cluster (PDC) based grading have been proposed recently in 2012 by Ueno H et al., PDC is defined as a solid cancer cell nest comprising ≥5 cancer cells, lacking a gland-like structure. Aim: To compare PDC based grading with conventional World Health Organisation (WHO) grading in resected specimens of colorectal adenocarcinomas and to evaluate the relationship of PDC grading with known prognostic histopathological parameters. Materials and Methods: The present study was a descriptive study done duration of three years and two months in the Department of Pathology, JSS Medical College and Hospital, Mysuru, Karnataka, India. A total of 60 CRC cases were studied. WHO grading was done according to eighth edition, 2018 of the American Joint Committee on Cancer (AJCC) staging system. Haematoxylin and Eosin (H&E) stained slides were studied by two pathologists and looked for inter-observer variability by k statistics. Finally, both pathologists arrived at a consensus and was subjected for PDC grading and correlated with other prognostic histological markers. The comparison of data was done by Pearson’s Chi-square test and t-test. The p-values <0.05 were considered statistically significant. Fleiss-Cohen’s weighted k statistics was used for the assessment of inter-observer variability in tumour grading. Results: There was significant association between PDC grading and WHO grading with k-value of 0.852 and p-value of 0.001. The maximum cases on PDC grading were of G-II type-29 (48.3%) followed by G-III-25 (41.7%) and G-I-6 (10%). There was increase in G-II and G-III carcinomas, as mucinous adenocarcinoma and signet ring cell carcinomas were also graded with PDC which was not possible with current WHO grading system. Conclusion: Present study findings suggest that PDC grading is more reproducible and provides better prognostic stratification as it is less subjective than the conventional WHO grading.
Influence of Nitrogen Levels on Physiological Response, Nitrogen Use Efficiency and Yield of Rice (Oryza sativa L.) Genotypes
Authors: Kunta Rajesh , Thatikunta Ramesh
Published: February 2021

A field experiment was conducted during 2011-12 to evaluate the efficiency of varying nitrogen fertilizer rates on growth and yield parameters, along with nitrogen use efficiency with two nitrogen levels 60 and 120 kg N ha-1 as main treatments and twenty six rice genotypes as sub treatments. Application of appropriate level of nitrogen fertilization is a major objective to increase nitrogen use efficiency by rice varieties. Among the genotypes, MTU-1001 recorded the maximum grain yield of 5021 kg ha-1 even under application of 60 kg N ha-1 with maximum NUE (Nitrogen Use Efficiency) in 60 kg N ha-1 (83.68) and minimum in 120 kg N ha-1 (45.53). NUE did not increase linearly with the amount of nitrogen application and higher nitrogen levels showed significantly lower NUE values. Maximum yield can be attributed to maximum SCMR (SPAD Chlorophyll meter reading) values, more photosynthetic rate, more tillers and panicles, more number of grains hill-1, maximum filled grain percentage and minimum spikelet sterility.
Endoscopic Approach to Benign Anastomotic Stricture in the Upper Gastrointestinal Tract
Authors: Erşen Ogün , Mercan Ümit , Yüksel Cemil , Akbulut Serkan , Ünal Ali Ekrem , Bayar Sancar , Demirci Salim
Published: February 2021

Introduction: Benign anastomosis strictures are frequently seen in anastomoses performed after upper gastrointestinal system resections. Although the first step in treatment is the preferred endoscopic procedures, surgical treatment is also an option. Mortality and morbidity of surgical treatment is at a very high rate compared to endoscopic approaches.

Materials Methods: 523 surgical operations, which underwent UGI resection and anastomosis between 31 December 2014 and 31 December 2019 at the surgical oncology clinic, were retrospectively scanned from the hospital database. All patients were those who had surgery for malignancy.

Results: The median age of the patients was 55 ± 12 (32-78) and 55% (n = 10) patients were male and 44% (n = 8) patients were female. When the patients were evaluated in terms of their current symptoms at the time of admission, the most common symptom was reported as dysphagia with 83% (n = 15) of the patients. 66% (n = 12) nausea was present.

Discussion: Indication should be selected by considering the indications in stent and balloon dilatation in anastomosis strictures. Balloon dilation can be considered as the main procedure. Stricturotomy, cauterization are also among the options of treatment. Endoscopic treatment can be done safely in qualified hands
Bioanalytical Method Development and Validation for the Simultaneous Determination of Vildagliptin and Telmisartan in Rabbit Plasma Using RP-HPLC
Authors: Reddy Budideti Kishore Kumar , Sekhar Kothapalli Bonnoth Chandra , Mohan Chinnala Krishna
Published: February 2021

A simple, reproducible bioanalytical method of liquid chromatography and PDA detector was developed and validated for the simultaneous Determination of Vildagliptin and Telmisartan in Rabbit Plasma using liquid-liquid extraction technique. K2 EDTA was used as anti-coagulant. Analytes were extracted by Methyl-tert-Butyl Ether (MTBE) and subsequent separation on a Kromasil C18 column (5 µ, 100 × 4.6 mm) using Acetonitrile : Methanol 75:25 v/v as mobile phase at a flow rate of 1 mL/min and (40±1)°C column oven temperature. Analytes were monitored with PDA detector at an isosbestic point of 225 nm for both Vildagliptin and Telmisartan.  Retention times of Vildagliptin and Telmisartan were found to be at 2.545 mins and 6.633 mins respectively. The method was validated over a linear (r2 = 0.9979) concentration range of 24.979 - 5003.808  µg/ml for Vildagliptin and 1.011- 202.559 µg/ml for Telmisartan. The inter-day and intra-day precisions were found to be less than 15% and the accuracy was all within ±15% (at LLOQ ±20%). The developed HPLC-PDA method was fully validated for all the other parameters as per FDA guidelines like selectivity, matrix effect, recovery and stability as well. Due to the high degree of sensitivity, very less time consuming, easy extraction procedure and low requirement of sample volume, the method will be applicable for therapeutic drug monitoring.
Anti- Parkinsonian Drug Estimation by RP-HPLC
Authors: Nadendla Rama Rao , Abhinandana Patchala
Published: February 2021

Aim: The main aim of the current study is to give best and simple method for the estimation of antiparkinsonian drugs named Carbidopa, levodopa and entacapone.

Study Design:  Simultaneous estimation of Carbidopa, levodopa and entacapone was performed by using Quadrapumped (SHIMADZU Prominance-i, LC-2030C) RP-HPLC equipped with PDA detector.

Place and Duration of Study: Chalapathi Drug Testing Laboratory, Chalapathi Institute Of Pharmaceutical Sciences, Lam, Guntur-522034, Andhra Pradesh, India during the period of August 2019 to February 2020.

Methodology: The assets of the study can determined as the process of qualification and quantification was done on SHIMADZU Prominance-i, LC-2030C system equipped with Phenomenex ODS (150 x 4.6 mm, 5μm) column and mobile phase was optimized using combination of acetonitrile and 0.1% ortho phosphoric acid in the ration of 50:50 v/v at a flow rate 1.0 ml/min. The wavelength was set as 270nm at ambient temperature by injecting 20µl of solution and the run time was fixed for 5 min.

Results: Calibration plot shown best regression over the concentration range of 5-160 µg/ml of Carbidopa, Levodopa and Entacapone standard solutions. The LOD and LOQ were found to be 0.85 and 2.54 µg/ml for Entacapone, 0.24 and 0.71 µg/ml for Levodopa, 0.14 and 0.43 µg/ml for Carbidopa respectively. The accuracy of the proposed method was determined by performing recovery studies and was found to be between 98-102%. The repeatability testing for both sample and standard solutions was found as %RSD<2.0% which is within the acceptable limits showing that the method is precise as well. The proposed method was successfully applied for the marketed formulations of Carbidopa, Levodopa and Entacapone tablets. In addition the main feature of proposed method is economic and eco-friendly with less retention time around 5.0 min.

Conclusion: Including all the optimized method parameters and statistical results given it can be concluded as a new, simple, sensitive, precise and accurate economical analytical method was developed and validated by RP-HPLC for the detection and quantification of Carbidopa, Levodopa and Entacapone which can be applied to the marketed formulation where there are no official compendial methods reported for this particular combination. The high sensitivity (LOD), mobile phase utilized and run time (=5) can be determined as an important features for this proposal.
Evaluation of Haematological Alterations in Children Infected by Plasmodium falciparum Species in Enugu, Enugu State, Nigeria
Authors: Ogbonna Linda Nnenna , Ufelle Silas Anayo , Obeagu Emmanuel Ifeanyi , Ogbonna Cyril Okonkwo
Published: February 2021

Malaria accounts for a considerable amount of Morbidity and mortality with children bearing the greatest burden. The study aimed to investigate the haematological alterations in children infected by Plasmodium falciparum (P. falciparum) species. A case control study with a total of ninety-five microscopically confirmed P. falciparum malaria infected children and fifty apparently healthy age and gender matched controls from Enugu State University Teaching Hospital, Parklane, Wesley Specialist Hospital and Akpugo Community Health Centre, Enugu were recruited for the study. Haematologic parameters were estimated using five part differential automated analyzer (Mindray BC 5300) with ethylene-diamine-tetra-acetic-acid anticoagulated blood. ­­The result of P. falciparum infected male children revealed significant decrease (p < 0.05) in haematocrit (32.76 + 4.82)%, haemoglobin  (10.34 + 1.46) g/dl, white blood cell (3.65 + 2.81)x109/L, neutrophil (20.41 + 15.16)% and platelet (228.41 + 113.51) x109/L, compared to  the controls; haematocrit (35.60 + 2.70)%, haemoglobin (11.27 + 0.90) g/dl; white blood cell (7.97 + 2.55)x109/L, neutrophil (30.33 + 8.04)% and platelet (315.45 + 53.64) x 109/L.  It also showed a significant increase (p < 0.05) in monocyte (3.28 + 2.63)%, basophil (1.68 + 1.15)% compared to the controls; monocyte (1.89 + 1.10)%, basophil (0.44 + 0.46)%. The results of P. falciparum infected female children revealed significant decrease (p < 0.05) in white blood cell (4.93 + 2.95)x109/L, neutrophil (19.61 + 15.14)%, mean corpuscular haemoglobin (23.58 + 2.37)pg, mean corpuscular volume (74.67 + 8.00)fl, and platelet (257.00 + 129.55) x109/L compared to the controls; white blood cell (6.70 + 1.75) x109/L, neutrophil (26.91 + 7.97)%, mean corpuscular haemoglobin (25.12 + 1.96)pg, mean corpuscular volume (79.13 + 5.37) fl and platelet (303.13 + 54.02) x109/L, significantly increased (p < 0.05) monocyte (3.38 + 2.78)%, basophil (2.19 + 1.36)% as compared to the controls; monocyte (1.85 + 0.82)%, basophil (0.48 + 0.45)%. However, P. falciparum infected male children showed to be more anaemic compared to the infected females.  Indeed, Plasmodium falciparum malaria infection in children has great impact on the haematologic parameters, thus its investigations serves as competent measures of differential diagnosis.
Work-related musculoskeletal disorders and associated risk factors among urban metropolitan hairdressers in India
Authors: Mishra SukhDev , Sarkar Kamalesh
Published: February 2021

Objectives

Ergonomic hazards account for a substantial proportion of work-related diseases and injuries among hairdressers. Awkward posture during work, repetitive movements, prolonged standing, and long working periods to carry out work activities cause mechanical load on the joints and work-related musculoskeletal disorders (WMSDs). This study investigated the musculoskeletal problems among urban hairdressers and associated risk factors.

Methods

This study investigates the prevalence of WMSDs among 768 study subjects (384 hairdressers and control subjects each) from Ahmedabad and New Delhi metropolis in India. Univariate statistical analysis was carried out along with 95% confidence interval for effect estimates.

Results

Findings reveal that the nearly half of the hairdressers suffered from knee and foot pain (49.5%), followed by lower back pain (39.8%) and upper back pain (38.8%). The neck pain and shoulder pain were reported by more than 25% hairdressers. The odds of developing neck pain (OR = 2.04; 95% CI 1.37-3.06) and shoulder pain (OR = 1.85; 95% CI 1.25-2.73) were significantly higher than control. The female hairdressers were more likely to experience work-related musculoskeletal disorder (OR = 2.63; 95% CI 1.18-5.86) than male counterparts. Hairdressers within the age of 18-35 years had significantly higher occurrence of musculoskeletal disorders with longer duration of working hours at the workplace. Longer daily work hours (>12 hours) posed significantly higher risk (OR = 2.47; 95% CI 1.39-4.38) of experiencing MSD for hairdressers.

Conclusion

A very large proportion of hairdressers suffered with work-related musculoskeletal disorders. The long daily working hours and gender of the hairdresser are associated with increased risk of developing WMSDs.