bluuebunny/crossref_metadata_2025 huggingface dataset:
Effect of combined use of atorvastatin and hormonal therapy on serum prostate-specific antigen, urinary function, and quality of life of early prostate cancer patients in intensive care unit
Authors: Xiao Li , Liao Jiaoe
Published: August 2022

Purpose: To determine the effects of combined use of atorvastatin and hormonal therapy on serum levels of prostate-specific antigen (PSA), urinary function parameters, and quality of life (QOL) of intensive care unit (ICU) patients with early prostate cancer (PCa).

Methods: The clinical data for 90 PCa patients treated in ICU of Chenzhou First People's Hospital, Chenzhou, China from July 2019 to July 2020 were retrospectively analyzed. The patients were divided into a reference group given intensity-modulated radiotherapy (n = 45), and a study group treated with intensity-modulated radiotherapy + atorvastatin + hormonal therapy (n = 45) sequentially as they were admitted. After the treatments, serum PSA levels of the patients were measured using enzyme-linked immunosorbent assay (ELISA), while QOL was measured based on Expanded Prostate Cancer Index Composite (EPIC). Urinary parameters were determined by measuring various urodynamic indicators.

Results: Compared with the reference group, the study group had significantly lower post-treatment serum levels of PSA and blood lipids, higher levels of urinary function indicators (except for residual urine volume), and higher scores in IIEF-5 and EPIC (p < 0.001).

Conclusion: These results demonstrate that the combined use of atorvastatin and hormonal therapy is a reliable method for improving urinary function and QOL in early PCa patients. Moreover, the combined treatment has potentials for reducing serum levels of PSA and blood lipids in PCa patients. These findings may be useful in the establishment of improved therapy for early PCa.

Keywords: Atorvastatin; Hormonal therapy; Early prostate cancer; Serum PSA; Urinary function; Quality of life
MicroRNA-542 suppressed the proliferation of human glioma cells by targeting talin-2 (TLN2)
Authors: Li Jinlan , Mo Jiapeng , Liu Qunhui , Li Wenjing , Yang Shijun , Tan Minghui , Zhong Jianhua
Published: August 2022

Purpose: To investigate the effect of miR-542 in the development of human glioma.

Methods: The expressions of miR-542 and TLN2 in glioma cells and normal human astrocytes were determined using qRT-PCR, while MTT and colony formation assays were used to determine cell proliferation. Western blotting was used to determine protein expression.

Results: It was revealed that miR-542 was significantly downregulated in glioma cells. Overexpression of miR-542 inhibited the proliferation and clonogenicity of glioma cells via induction of apoptosis. The percentage of apoptotic U87 cells increased from 5.32 in control to 26.76 upon miR-542 overexpression. Moreover, TLN2 was identified as the functional regulatory target of miR542 in glioma. The expression of TLN2 was markedly upregulated in human glioma cells. However, overexpression of miR-542 suppressed TLN2 expression. Silencing of TLN2 mimicked the tumor-suppressive effects of miR-542 in glioma cells, but this effect was blocked by TLN2 over-expression.

Conclusion: These results suggest that miR-542 exerted glioma-suppressive effect, with TLN2 as its functional regulatory target.

Keywords: Glioma; Proliferation; Micro-RNA; Tumorigenesis; MiR-542; Apoptosis; Prognosis; talin-2; Oncogene
Editor's Note
Authors: Nyarwath Oriare
Published: August 2022

Not available
Review of fisheries and management of sea cucumbers in the Indian Ocean
Authors: Conand Chantal , Claereboudt Michel , Dissayanake Chamari , Ebrahim Ameer , Fernando Stella , Godvinden Rodney , Lavitra Thierry , Léopold Marc , Mmbaga Twalibu K. , Mulochau Thierry , Naaem Shafiya , Shea Stanley , Vaitilingon Devarajen , Yahya Saleh , Friedman Kim
Published: August 2022

Several sea cucumber species (Echinodermata: Holothuroidea) are fished, mostly for export of the dried product for Oriental consumers. Previous studies had analysed the historical trends at the world-scale until 2014. In the Western Indian Ocean (WIO) holothurian fisheries have a long history and several programmes have tried to ameliorate their management. Information has been recently gathered through a questionnaire and access to the most recent, yet unpublished available data (2015 to 2021) from different countries, through the evaluation of catches and/or processed product, present management systems, the imports of beche de mer and other products from Indian Ocean (IO) countries into the major market hub of Hong Kong SAR, and the Food and Agricuture Organisation (FAO) yearly statistics. The results are first presented for WIO countries, highlighting recent improvements in management. Imports from 16 WIO countries into the Hong Kong market (2017-2020 data) indicate the importance of the hub. The FAO world statistics are used to present the changes for the last few years, concentrating on the WIO countries. The recent trends show that demand for holothurians is still very high. Inconsistencies in the unit used in the reported statistics (fresh or dry weight) exist, and this needs to be addressed. The national data should be collected at the species level, to be able to follow the changes and the stock status. A regional approach is needed to encourage use of comparable management tools and follow future trends.
Use of physicochemical parameters and metal concentrations in assessing anthropogenic influences on coastal rivers in Dar es Salaam, Tanzania
Authors: Mhande Zakaria , Mihale Matobola J. , Hellar-Kihampa Harieth
Published: August 2022

Spatio-temporal variations in water quality of three rivers along the Indian Ocean coast in Dar es Salaam, Tanzania, were investigated based on physicochemical parameters and metal concentrations. A compliance analysis was performed based on the Tanzania Bureau of Standards (TBS) and World Health Organization (WHO) limits to examine the suitability of water for domestic use. The dataset was subjected to statistical analysis to determine differences and similarities amongst the rivers. Levels of pH (6.83-11.41), total dissolved solids (203–34,333 mg/L), electrical conductivity (9,408-68,014 μS/cm), turbidity (10.0-45.0 NTU), chloride (108-14,248 mg/L), sulphate (35-766 mg/L) and ammonium (40-5,468 μg/L) complied with neither TBS nor WHO limits. Dissolved oxygen (1.4-6.6 mg/L), chemical oxygen demand (91-1,863 mg/L), total suspended solids (11.9-50.7 mg/L), alkalinity (200-2,658 mg/L), total hardness (362-12,1312 mg/L), salinity (0.19-29.35 ppt) and phosphate (<method detection limit-3.01 μg/L) indicated polluted water in parts of the rivers. Pb (0.7-24.0 μg/L) exceeded both the TBS and WHO limits, whereas Cr, Cu, Fe, Zn and Cd were below limits. Water quality was poorer during the wet season. The results indicate that water from the rivers is unsafe for human consumption and the poor water quality probably also affects the ecology of the rivers. Strategic measures to protect the rivers from further contamination are suggested.
The influence of household human and social capitals on participation in agricultural development initiatives in the coastal region of Kenya
Authors: Ong'ayo Annie H. , Hassan Farida A.
Published: August 2022

The present study sought to establish the human and social capital that determines rural households’ participation in agricultural projects and programmes implemented by the Kenyan government and development partners. The research was carried out among rural households in the three counties of the coastal region of Kenya. Multi-stage sampling techniques (purposive, proportionate random and simple random sampling) were used to select the study area and the study sample. Data were collected using a semi-structured questionnaire, Focus Group Discussion and observation schedules. The data analysis was carried out using descriptive statistics and regression analysis with the help of the Statistical Package for Social Sciences Version 22. The findings revealed that individuals with human capital; namely age (-0.15), primary education (-0.16), secondary education (-0.14), vocational training (0.35), and on the of job training (0.25), have a higher likelihood of participating in agricultural development initiatives. Households with the social capital of membership to groups (0.51), engaged in economic activities (0.53) and have linkages with development agencies (0.44) have a higher likelihood of participating in development initiatives. Key policy recommendations for county government and development partners include: encourage the community members to enrol in adult education; provide support for vocational and technical training; register as members in existing groups or form groups based on common interest, and engage in economic activities. The county governments should enhance advisory services to ensure close contact with professionals who will facilitate training, meetings and interactions with groups leading to the empowerment of members.
PKM Keterampilan Membuat Bar Soap, Knitting, dan Roti Sehat sebagai Pemberdayaan Perempuan di Desa Sei Mencirim Kabupaten Deli Serdang
Authors: Asriyati  , AK Marlya Fatira , Destiadi Rezha , Siregar Delisma
Published: August 2022

Program Pengabdian Masyarakat ini berjudul PKM Keterampilan Membuat Bar Soap, Knitting, dan Roti Sehat sebagai Pemberdayaan Perempuan di Desa Sei Mencirim Kabupaten Deli Serdang. PKM ini bertujuan untuk memberikan solusi masalah mitra mengenai ketidaktersediaan alat produksi, ketidaktersediaan sarana untuk mendukung media pemasaran produk secara digital. Keterbatasan alat produksi produk, belum optimalnya pemasaran produk dan belum memperoleh izin dari BPOM, serta sertifikasi Halal. PKM ini menggunakan metode blended Virtual, daring dan luring, dikarenakan saat ini masih masa Pandemi Covid-19. Pengumpulan data dilakukan melalui wawancara. Hasil perolehan data dan informasi dari mitra selanjutnya dianalisis secara deskriptif, dilakukan musyawarah mufakat bersama mitra tentang perioritas penyelesaian masalah dan kontribusi yang akan diberikan mitra untuk kegiatan PKM. Hasil dari kegiatan pengabdian adalah mitra menjadi memiliki kemampuan untuk melakukan pemasaran digital produk usahanya, mitra mampu meningkatkan jumlah produsi barang sesuai permintaan pasarnya dengan pengetahuan untuk pemanfaatan media sosial dalam pemasaran menjadi lebih baik dan maksimal untuk diterapkan mitra.
TEACHERS' VIEWS ON TEACHING WITH THE DESIGNED GAME 'MY PLACE ON THE PLANET'
Authors: SAYKAL Ahmet , KARAMUSTAFAOĞLU Orhan
Published: August 2022

In this research, it is aimed to determine the teachers’ views on teaching the Solar System subject of the 6th grade science course with a game titled My Place on the Planet. The study was carried out within the scope of the phenomenology method in a qualitative research design. Semi-structured interview technique, one of the qualitative data collection techniques, was used in the research. Easily accessible case sampling, one of the purposive sampling methods, was used to collect data. The study group consists of ten science teachers who personally conduct the 6th grade science course in randomly selected state secondary schools in the province of Amasya in the 2019-2020 academic year. The analysis of the research data was analyzed using content analysis, and the data were presented as frequency, percentage and one-to-one expressions of the teachers according to the themes created. According to the research findings, it was determined that science teachers frequently used the method of teaching with games in their lessons, teaching with games provided permanence in learning, active participation of students in teaching provided learning with fun, and teaching with games gave cognitive, affective and psychomotor skills. In addition, it has been concluded that the game titled My Place on the Planet will bring the intended gains and will be effective in teaching the subject of the Solar System. At the end of the study, recommendations based on the research results were presented to the interested parties.
IMAMAT ACCORDING TO THE JAFARI SCHOOL OF SHIATE
Authors: ZUFTAROV ALIMAHAMMAD
Published: August 2022

Studies in some areas need to be reconsidered because they do not meet the need, are incomplete or incorrect. There are different reasons for this. If the researched subject is a sensitive subject of any sect, it should be researched and explained correctly, trying to maintain the same sensitivity. Besides, when considering the opinion of a sect, the sources of different sects should be consulted and a research far from bigotry should be revealed. If the allegations are not taken into consideration, we think that the same study should be handled again, since the study will not meet the need, and it will be incomplete or misunderstood. That's why we preferred to investigate the issue of imamate in Jafarism. The Shiite Jafari creed on the issue of imamate, being discussed among Islamic sects, is handled in this study. The views of different sects on imamate are mentioned and compared with the views of the Jafaris. The basis of the Jafari's taking the issue of imamate as a basic belief and the nasses that can be evidence for the Jafari scholars' own claims on the issue of imamate are discussed and their explanations on them are analyzed.
THE YOUTH PROTESTS OF 68 GENERATION IN TURKEY
Authors: KARAÇELİK Ali Rıza
Published: August 2022

The pro imperialist atmospher which became widespread after the 2. World War, found hars responses in many states. Especially since the beginning of the 1960s, it gave birth tothe ’68 generation’, whose name will be referred to as the events of 1968 in history and will guide the next period. This movement, wich contains discourses such as freedom equality and dependence and was accepted espsciallyamong the universty youth of the period, tried to change and transform everything that was contrary to its discourses. In this study, the structure of the period in which the 1968 events, know as the ’68 generation’emerged in Turkey and how they affected the society, will be discussed in the light of the events experienced during the period.
YOUTH UNEMPLOYMENT PROBLEM IN DEVELOPING COUNTRIES AND SOLUTIONS FOR TURKEY
Authors: KAYA Abdurrahman
Published: August 2022

The unemployment problem, which started to become widespread with the Great Depression of 1929, started to affect the whole world with the increase of globalization. Most of the countries' economies have recently turned to struggling with the unemployment problem and have tried to produce policies in this direction. The problem of youth unemployment, which we can consider within the unemployment problem, has emerged as another issue that needs to be struggled for the national economies. The fact that young people, perhaps the most important factor in the development of countries, cannot be included in the market mechanism and remain idle in the economy has created problems for many economies. This research aims to examine the causes of youth unemployment in developing countries and to present rational and original solutions to these problems in Turkey. In this study based on the literature review, the causes of youth unemployment are elaborated by emphasizing the concept of youth unemployment and the structure of youth unemployment, the structure of youth unemployment in developing countries and Turkey has been examined in the light of data from institutions such as TUIK, International Labor Organization and the World Bank and solution proposals that can be used to combat youth unemployment in Turkey are listed. In terms of accepting the data used as more up-to-date, the fact that it covers the years 2000-2020 and that some countries that can be economically and socially equivalent to Turkey have been selected among the developing countries are the limitations of this study. Considering the data obtained, it has been determined that the share of graduates, especially at the higher education level, among the young unemployed is much higher than the graduates with a lower level of education, and this is due to the education-employment relationship.
20. Yüzyılda Modernizmin Çağdaş Türk Resim Sanatına Etkileri
Authors: ŞEN Emre , ÇIVKIN Ayşe
Published: August 2022

İnsanlık tarihi ile başlayan ve yaşamımızın bir parçası haline gelen sanat, Modernizmin etkisiyle kendini değiştirmiş ve çağın gereği olarak yenilemiştir. Dünyada sosyo-ekonomik, teknolojik ve kültürel gelişmelerin sanat alanlarına yansıması ile gruplaşma eğiliminin giderek azaldığı, bireyselliğin ön plana çıktığı, bununla birlikte, sanatçıların, daha özgün ve çağdaş kimliğe dönük çalışmalara imza attıkları bilinmektedir. Çağdaş Türk resim sanatının özgün kimlik arayışı, kimi zaman batı resim kavramlarını ve teknik detayları kimi zaman da tarihsel kaynakların kökenine yönelerek ortaya çıkartılmıştır. Uluslararası alanda Resim sanatında yaşanan sanatsal gelişimlerin, Çağdaş Türk Resim sanatına yansımasını ortaya koymayı hedefleyen bu çalışma, sanatta batıya açılma süreci ile başlayan ve yıllardan beri devam ederek günümüzde de hala tartışılan yeni kimlik kavramını, tarihsel gelişime koşut olarak, sanatçıların eserleriyle irdelenerek hatırlatılması adına bir katkıda bulunma gerekliliği ile hazırlanır. 20. Yüzyıl resim sanatında farklı akımlar içerisinde yer alan Türk Ressamlarının yaptıkları çalışmalar, Türk kültür, gelenek, görenek ve yaşantılarını yansıtmışlardır. Bu nedenle araştırma bu sınırlılıklar içerisinde yapılmış, modernizm sürecinin Türk resim sanatına yansıması irdelenerek, sanat eserlerinden seçkilerle desteklenmiştir. Bu makale, Modernizm kavramı, Modern sanat, Çağdaş Türk Sanatı ve 20. Yüzyıl Modernizminin Çağdaş Türk Resim Sanatına Etkileri başlıkları altında toplanmış olup bu amaç ve önem doğrultusunda nitel araştırma yöntemlerinden literatür taraması kullanılarak oluşturulmuştur.
INFORMALNO UČENJE KAO PRILIKA ZA PERMANENTNO OBRAZOVANJE NASTAVNIKA
Authors: Kalmar Laura
Published: August 2022

In the existing pedagogical literature, the need for permanent, continuous improvement of teachers and teacher competencies is emphasized. In that context, the ideal tool for that is informal education. “Informal education” is a term often used to describe learning activities from everyday life. Informal education is defined as a lifelong process in which each individual acquires attitudes, values, skills and knowledge from everyday experiences and educational influences from their environment - family and neighbors of work and play, libraries, museums, markets, mass media. Informal education is a combination of life and learning and relies on systematic and cumulative aspects of everyday experiential learning. The aim of this paper is to show the importance of informal education, to point out its basic segments, characteristics, as well as to show the importance of lifelong learning of teachers. The importance of the topic of this paper is extremely great, due to the need for permanent (lifelong) learning of teachers and the importance of informal learning. During this research, the emphasis was on the study of existing literature. The research was conducted on the basis of content analysis, which is based on the study of secondary sources. The tasks of the research were as follows: 1. to point out the concept of informal education, 2. to point out the characteristics of informal education, 3. To point out the importance of permanent teacher education, 4. to point out the necessity of continuous improvement of teacher competencies. The need to study this topic is extremely great due to the importance of informal education, as well as the importance of permanent teacher education and the need for continuous improvement of teacher competencies.
La economía social y solidaria como alternativa para la superación de la pobreza rural: análisis de una experiencia en Guatemala
Authors:   , Jiménez Fuentes Byron Javier
Published: August 2022

Las diferentes esferas de la vida humana han sido fuertemente impactadas durante los dos últimos años, debido a la actual pandemia del Covid-19. Además de la salud, la economía familiar ha sufrido cambios repentinos, agravando la pobreza principalmente en las regiones rurales de países en desarrollo. Desde un análisis multidimensional de la pobreza, esta impacta aspectos fundamentales como salud, educación, trabajo, condiciones de vida, ingresos, etc. Frente a tal problemática, el presente documento procura comprender de qué forma los principios de la economía social y solidaria (ESS) se materializan en la vida de las comunidades rurales de Quetzaltenango, Guatemala. Esto, examinando el impacto de este modelo en la generación de trabajos inclusivos e ingresos justos, así como analizando de qué forma la participación femenina repercute en la reproducción social familiar. Esta investigación aplicó en primeria instancia una metodología de revisión de literatura, para contribuir en la comprensión de la pobreza rural y las alternativas para reducirla. Así también, a través de encuestas y entrevistas se obtuvo datos primarios para estudiar específicamente los efectos da la ESS en la vida de los asociados a PECOSOL-GT. Los datos teóricos y empíricos, fueron analizados posteriormente de manera manual. Los resultados permitieron identificar evidencias positivas de varias prácticas implementadas alrededor del mundo. Resaltaron entre ellas el emprendimiento en India y la economía social y solidaria en América Latina; que son dos paradigmas con principios, valores y prácticas distintas. Esta metodología permitió concluir que ciertamente cada territorio necesita combatir la pobreza rural con prácticas específicas que consideren su propio entorno. Así también, se evidenció empíricamente que los principios de la ESS se materializan en la vida de los campesinos rurales a través de la generación de más trabajos inclusivos y como consecuencia, facilitando el incremento de los ingresos familiares. También se concluye que la participación femenina en este modelo impacta positivamente las dimensiones material, biológica y social de la reproducción social familiar, a través de la mejora de la economía, cuidado del medio ambiente, salud, educación, participación política, social y cultural. Cabe resaltar que este trabajo contribuye en el auxilio de investigaciones científicas futuras con temáticas semejantes. A la vez, procura también influenciar el establecimiento, formulación y reorientación de políticas, programas y estrategias que busquen combatir la pobreza rural en países en desarrollo. Palabras clave: Combate a la pobreza. Emprendimiento. Economía social y solidaria. Reproducción social familiar.
Digitalisasi, Era Tantangan Media (Nalar Kritis dan Penguatan Wawasan Global di Era Digital)
Authors: Shofan Moh
Published: August 2022

Artikel-artikel dalam jurnal ini secara umum melihat secara kritis layanan teknologi informasi, baik proses pengolahan dan berbagi informasi. Kemampuan berpikir kritis di dalam masyarakat informasi, menjadi sangat penting agar setiap individu dapat memilih dan menggunakan informasi yang tersedia sesuai kebutuhan dan kepentingannya. Terlebih dengan adanya andemic Covid-19 di tahun 2019 hingga adanya berbagai varian baru membuat media digital sangat dibutuhkan masyarakat. Kegiatan apapun yang awalnya dilakukan secara offline satu dengan yang lain bisa berinteraksi secara langsung seketika dibatasi dengan kegiatan secara online. Dampak penyebaran pandemic yang sangat cepat membuat manusia merasakan ketakutan tersendiri. Masyarakat berkomunikasi melalui media sosial yang mengakibatkan penggunaan internet pada masa pandemic sangat meningkat drastis.
Наука фарабабиеведение и формирование института философии и права (на основе архивного фонда академии наук Республики Узбекистан)
Authors: Имангалиев Алмас , Дукенбаева Задаш , Тураев Бахтиёр
Published: August 2022

Научная статья авторов о формировании Института философии и права при Академии наук Республики Узбекистан и о фарабиеведах, которые внесли большой вклад в формирование и развитие науки фарабиеведение Республики Узбекистан.Становление фарабиеведения в Республике Узбекистан приходится на 60-е годы XX века. Так как именно в этот период в стенах Академии наук был создан Институт философии и права. Создание указанного Института связано с научной деятельностью д.филос.н., профессора, академика Академии наук Республики Узбекистан Муминова Ибрагима Муминовича.В ходе научной работы, проведенной в Международном научно-исследовательском центре Имама Бухари, авторы смогли узнать о деятельности нескольких исторических личностей и познакомиться с их наследием касательно становления и развития фарабиеведения в Республике Узбекистан (И.М. Муминов, Т.Н. Кары-Ниязов, С.Х. Сиражидинов, А.Ф. Файзуллаев, М.М. Хайруллаев, М.Б. Баратов и др.).Данная статья была подготовлена на базе Международного научно-исследовательского центра Имама Бухари в рамках одноименной международной стипендии.
Az én városom : Identitás – elégedettség – kötődés – márka és a belső városmarketing
Authors: Piskóti István
Published: August 2022

A városok alapvető küldetése, hogy jó lakóhelyet, jóllétet teremtsenek polgáraik számára. Egy attraktív, versenyképes város sikeresen megoldja azokat a problémákat, hogy az itt élők elégedettek legyenek, szeressék, magukénak érezzék a várost, erős identitással kötődjenek hozzá. A cikk bemutatja a célok eléréshez nélkülözhetetlen városmarketinges elemzési, mérési és belső tervezési és kommunikációs módszertant, s empirikus elemzésre épülően fogalmaz meg javaslatokat Kecskemét számára.
UHALISIA wa MAUDHUI YA USALAMA KATIKA FASIHI ya WATOTO:MFANO wa RIWAYA ya KIJANA MPELELEZI,WAMITILA K.W (2003) na USIKU wa MANANE,KOBIA J. (2010)
Authors: MBOYA ROSE NDANU
Published: August 2022

Makala hii inachunguza uhalisia wa maudhui ya usalama katika fasihi ya watoto kwa kuchanganua riwaya ya Kijana Mpelelezi (Wamitila,2007) na Usiku wa Manane (Kobia, 2010). Hadithi hizi za watoto zimejikita katika fasihi ya watoto. Madhumuni ya utafiti huu ni kubainisha masuala ya usalama yaliyodhihirishwa na waandishi wa riwaya za Usiku wa Manane (Kobia ,2010) na Kijana Mpelelezi (Wamitila,2007), kueleza jinsi wahusika watoto wanaohusishwa na maudhui ya usalama wanavyosawiriwa na kutathmini uhalisia wa maudhui yanayohusu usalama na yanayonuiwa watoto kama hadhira lengwa katika riwaya za Usiku wa Manane (Kobia,2010) na Kijana Mpelelezi (Wamitila,2007). Nadharia za uhalisia wa kijamaa na Soshiolojia ya fasihi zilitoa msingi madhubuti kuhusu mada husika. Makala hii inathibitisha kuwa masuala ya usalama yanayobainika yanafungamana na hali ilivyo katika maisha ya jamii ya karne hii ya ishirini na moja. Vita vya kikabila na ukosefu wa usalama katika jamii vinapaswa kuondolewa na kusahaulika kabisa. Hadithi za watoto za waandishi hawa zinadhihirisha uhalisia wa maudhui ya usalama. Ni dhahiri kuwa kuna haja ya kuchukua hatua za dharura kuwafahamisha watoto kuhusu umuhimu wa amani katika taifa ili wakikua wawe na uwezo wa kueneza maridhiano baina ya jamii lugha zote.
Identifying the Possible Measures to Minimize Material Waste Using Lean Construction
Authors: Sharma Madan , Mishra A. K. , Selvam Janani
Published: August 2022

Purpose: Continuous effort to assure material management is continued to identify the possible measures to minimize material waste in construction projects based on a lean construction approach.
Design/Methodology/Approach: The present study adopted Questionnaire Survey, Literature review, Study of project document for major sources of waste material, Possible Measures and Response in Scale of rating 1-5 using Relative Importance Index (RII).
Findings/Result: The discoveries uncover that Some of the significant places in the lean development approaches are: Adoption of legitimate site the board strategies, Accurate and great determinations of materials to try not to wrong request, Proper capacity of materials on location is additionally one of the actions for the waste material in the lean development, Purchasing unrefined substances that are simply adequate, Reduce Recycling and Reuse of a few waste materials on site. In this review, a few elements make issues in development ventures to execution of lean development approach for the undertaking's fruition. Because of various variables, the workers for hire can't finish the task successfully. This study gives proof fair and square of measure to conquer the obstructions to execution of lean development approach in development projects. The discoveries of this study are in concurrence with the impression of clients, experts, and workers for hire about the action to defeat the hindrances to execution of the lean development approach in development projects.
Originality/Value: The study contributes by assuring to Develop innovative practices and systems to control waste, delays, and cost overruns.
Paper Type: Action Research.
Plasma Rico em Plaquetas (PRP): uma nova abordagem das rotações por minuto (RPM)
Authors: Amadio Menegat Taís , Farina Thuanny , Meline Rosana
Published: August 2022

Conhecido também como plasma autógeno de plaquetas, plasma enriquecido com plaquetas e outras denominações similares, o PRP (plasma rico em plaquetas) é um concentrado autólogo de plaquetas obtido a partir da centrifugação do sangue total, onde seu potencial efeito é através da liberação de fatores de crescimento presentes nos alfa-grânulos plaquetários. No Brasil, o crescimento dos procedimentos estéticos tem entusiasmado pacientes que buscam melhorias faciais e corporais, tendo em vista que as novas técnicas que surgem prometem resultados visíveis com menor tempo e esforço para consegui-los. Muitos são os protocolos de rpm (rotações por minuto) para aumentar a concentração de agregado plaquetário, porém há necessidade de estabelecer um padrão de rotação (rpm), para obter a maior quantidade possível e com qualidade, do agregado plaquetário. O objetivo deste estudo foi encontrar a melhor rotação e tempo para obter uma quantidade maior de PRP+PRF.  Para a realização do estudo foram utilizadas 36 amostras, contendo 3,5ml de sangue que foram distribuídas em 9 grupos aleatórios, contendo 5 tubos de sangue cada e foram submetidas a rotações e tempo diferentes. Os resultados mostraram que houve diferença significativa no Grupo E e Grupo F, onde foi obtido maior na quantidade de PRP+PRF do que nos outros grupos. Os autores concluíram que utilizando a rotação de 4.000rpm com 3 minutos consegue obter uma maior quantidade de PRP+PRF.
Interview with Wouk Almino
Authors: Lanius Marcela
Published: August 2022

Elisa Wouk Almino is a writer, editor, and literary translator based in Los Angeles. She is the translator of This House by Ana Martins Marques (Scrambler Books), editor of Alice Trumbull Mason: Pioneer of American Abstraction (Rizzoli), and a senior editor at the online art magazine Hyperallergic. Her translations and essays have appeared in the Paris Review Daily, Lit Hub, NYR Daily, Asymptote Journal, Words Without Borders, and other places. She teaches literary translation and art writing at Catapult and UCLA Extension. In this interview, we discuss the translation project she has been working on since 2018, which revolves around some untapped archival material that belonged to Ana Cristina Cesar.
W. H. Auden em tradução: o verso livre de "Musée des Beaux Arts"
Authors: Tinelli Alexandre Bruno
Published: August 2022

Publicado em Another Time, no início de 1940, “Musée des Beaux Arts” pertence a um momento crucial da vida do poeta inglês W. H. Auden: sua emigração para os EUA, onde obteve a cidadania norte-americana em 1946. O poema baseia-se em quadros de Bruegel, o Velho, que Auden observou no Museu Real de Belas-Artes de Bruxelas, na Bélgica, em particular na pintura Paisagem com a queda de Ícaro. No texto, Auden aborda os temas da presença do sofrimento na vida cotidiana e da indiferença humana em relação à dor alheia, dois temas pertinentes num mundo que estava às vésperas da Segunda Guerra Mundial, quando o texto foi escrito. Esses temas recebem do escritor um tratamento formal apurado, que revela mestria no manejo da forma do verso livre. Neste artigo, efetuaremos uma análise detida do verso de “Musée des Beaux Arts”, observando o poema com atenção intensa e sustentada, de modo que seus movimentos de forma não nos escapem. Em seguida, apresentaremos nossa tradução do texto para o português brasileiro e comentaremos as estratégias tradutórias, que buscaram recriar, com alguma dose de liberdade, as principais características formais do original.
DEMOCRACIA, LIBERTAD E IGUALDAD: EL CONSTITUCIONALISMO SOCIAL ENTRE EL EQUILIBRIO, LA AUTORIDAD Y LA INTERVENCIÓN ESTATAL
Authors: Simon Henrique Smidt , Vila-Nova Daniel Augusto
Published: August 2022

Este artículo presenta aspectos políticos y jurídicos del constitucionalismo social en el pasaje del siglo XIX para el XX. El problema de la nación y el debate Kelsen-Schmitt permiten un análisis comparado entre las constituciones de carácter social de México (1917) y de Brasil (1934). La hipótesis es que derechos individuales y sociales y una estructura democrática no bastan para proteger contra el autoritarismo cuando prevalece la retórica del nacionalismo y de la identidad. Hay que buscar el equilibrio democrático en la efectuación de esas dos categorías de derechos, a garantizar niveles de solidaridad social para allá de la nación.
HUBUNGAN DUKUNGAN KELUARGA TERHADAP KEPATUHAN MINUM OBAT PASIEN TUBERKULOSIS PARU DI PUSKESMAS SUNGAI BILU
Authors: Warjiman Warjiman , Berniati Berniati , Er Unja Ermeisi
Published: August 2022

AbstrakDinas Kesehatan Kota Banjarmasin pada tahun 2018 melaporkan Puskesmas Sungai Bilu Banjarmasin menjadi wilayahyang paling banyak penderita Tuberkuloasis paru (TB Paru) berdasarkan Case Detection Rate (CDR) yaitu sebanyak93,4%. Penyebab utamanya adalah pengobatan TB paru yang tidak tuntas. Salah satu faktor yang berpengaruh padapengobatan pasien TB Paru adalah dukungan keluarga. Penelitian ini bertujuan untuk menganalisis hubungan dukungankeluarga terhadap kepatuhan minum obat pasien TB paru di Puskesmas Sungai Bilu. Rancangan yang digunakan adalahstudy corelational dengan analisa data menggunakan uji Spearman. Populasi dalam penelitian ini adalah pasien TB paruyang melakukan pengobatan di Puskesmas Sungai Bilu yang diambil dengan total sampling sebanyak 32 orang. Alat ukuryang digunakan dalam pengumpulan data kuesioner dukungan keluarga dan kuesioner Moriscky Medication AdherenceScale (MMAS-8). Hasil penelitian ini menunjukkan bahwa hampir seluruh responden mendapatkan kategori dukungankeluarga yang kurang yakni 30 orang atau 93,8% dan mendapatkan kategori kepatuhan rendah yakni 28 orang atau 87,5%.Hasil analisis bivariat spearman menunjukkan hasil sebesar 0,000 < α (0,05) dan nilai korelasi 0,767 yang artinya terdapathubungan atau korelasi positif yang sangat kuat antara dukungan keluarga dengan kepatuhan minum obat pasien.Penelitian ini menunjukkan dukungan keluarga terhadap pasien TB paru yang menjalani pengobatan di Puskesmas SungaiBilu masih rendah.Kata Kunci: Dukungan Keluarga, Kepatuhan Minum Obat, Tuberkulosis Paru
A UTILIZAÇÃO DE CANNABIS E SUAS APLICAÇÕES TERAPÊUTICAS PARA ANALGESIA NA CLÍNICA DE PEQUENOS ANIMAIS: REVISÃO BIBLIOGRÁFICA
Authors: Nepomuceno Prado Beatriz , Vaz da Silva Gonçalves Bruna , Mendes Brito Jhade , Regina Barberini Isis , Krychak Furtado Silvana
Published: August 2022

Introdução: A dor é frequente na cliníca de pequenos animais afetando diretamente no bem-estar dos pacientes. Diversas pesquisas acerca de novas opções para o controle da dor vêm se expandindo. Com isso, a mobilização de estudos sobre o Cannabis como opção analgésica vem ganhando destaque em virtude dos benefícios promovidos. Objetivo: O presente estudo busca analisar trabalhos acerca da utilização da Cannabis e suas aplicações para analgesia em pequenos animais. Métodos: Realizou-se estudo descritivo com análise de 16 artigos científicos na literatura obtidos através das bases de dados Google Acadêmico, Elsevier, PUBMED e SciElo. Resultados: Através da escala de dor foi perceptível diminuição da mesma em animais diagnosticados com osteoartrite, ao utilizar 2 mg/kg de um óleo canabidiol (CBD) derivado de cânhamo. Para redução da dor crônica em cães, foi utilizada uma dieta suplementada com administração de comprimidos no qual continham ingrediente naturais, onde cada tablete de 1,2g continha 10,08 mg de Cucumis melo, 35,64 mg de óleo de semente de cânhamo, 150mg Boswellia serrata e 2,4mg de Canabidiol 99,9% puro. Em outro estudo foram observadas reduções significativas na dor ao administrar 50mg/dia de CBD puro e 20 mg/dia de canabidiol lipossomal. Ainda ao utilizar este composto, de 32 cães, 10 suspenderam o uso de Gabapentina e 13 não pararam com o uso, sendo associadas as duas medicações. Conclusões: A utilização do CBD mostrou-se eficaz, tanto seu uso associado como isolado, mostrando-se uma nova alternativa no controle da dor em pequenos animais.
Kurtubalı İbnü’t-Tallâ‘ (öl. 497/1104) ve Akzıyetü Resûlillâh Adlı Eseri Üzerine Bir İnceleme
Authors: Altıntaş Fatma Betül
Published: August 2022

Hz. Peygamber’in bizzat kendisinin yaptığı yargılamalar neticesinde verdiği hükümleri içeren rivâyetlerin toplandığı çalışmalar, Akziye kitapları olarak adlandırılabilir. Hz. Peygamber'in yargılamalarını ihtiva eden akziye türü eserlerin tümü, Endülüs’te ve Mâlikî müellifler tarafından kaleme alınmıştır. Bu çalışma, Endülüslü Mâlikî fakîh ve muhaddis İbnü’t-Tallâ‘ın (öl. 497/1104) Hz. Peygamber’in yargılamaları neticesinde verdiği hükümlerinin yer aldığı rivâyetleri bir araya getiren kitabının içerik ve atıflarından yola çıkarak değerlendirilmesini içermektedir. Hz. Peygamber’in kazâî hükümlerinin müstakil olarak derlendiği Akziyetü Resûlillâh ismiyle bilinen bu eser, akziye türü kitapların telif amacı, içerik ve işlevlerini göstermesi açısından önem arz etmektedir. Eser, İbnü’t-Tallâ‘ın Kurtuba'da fetva verdiği dönemde bir nevi el kitabı işlevi görecek şekilde kaleme alınmıştır. Kitap, hem fıkıh hem de hadis alanına dair incelikleri barındırması sebebiyle her iki ilim dalına da katkı sağlamaktadır. Akziyetü Resûlillâh, hadis ilimleri açısından ahkâm rivâyetlerini içeren çalışmalar içerisinde konumlandırılabilir. Fıkıh alanında ise Akziyetü Resûlillâh'ın nevâzil türüne kaynak teşkil eden eserlerden kabul edilebilir.
Asciminib (Scemblix)
Authors: CADTH
Published: August 2022

CADTH recommends that Scemblix should be reimbursed by public drug plans for the treatment of Philadelphia chromosome–positive chronic myeloid leukemia (Ph+ CML) if certain conditions are met.

Scemblix should only be covered to treat adults with Ph+ CML who are in chronic phase (CP) with treatment failure on or intolerance to 2 or more prior tyrosine kinase inhibitor (TKI) therapies and have no evidence of T315I or V299L

Scemblix should only be reimbursed if prescribed by clinicians with expertise and experience in treating CML and if the cost of Scemblix is reduced.
A review on antimicrobial activities of some culinary herbs and spices against Staphylococcus aureus
Authors: BERBER Didem , TOKSÖZ Orçun , TÜRKMENOĞLU İpek , SESAL Cenk
Published: August 2022

Food safety is of great importance all over the world as it concerns consumer health. All employees in the food chain must comply with the hygiene rules. One of the important issues that threaten food safety is contamination with microorganisms. Numerous people are affected by contaminated and/or poorly preserved food and outbreaks have occurred. The World Health Organization (WHO) draws attention to human health and economic losses in this respect. From ancient times, herbs and spices are utilized in Türkiye and various parts of world to enhance the flavor of food and their sensory properties. It is also possible to prevent the development of Staphylococcus aureus, which causes food poisoning, thanks to the antibacterial properties of culinary herbs or spices. Thus, using natural antimicrobial substances from spices and herbs may be an alternative for inhibition/elimination of growth of S. aureus extending the shelf life without synthetic preservatives. This review aims to explain foodborne diseases and their global burden, staphylococcal food poisoning, natural antimicrobials, some edible herbs in Türkiye: their culinary uses and antibacterial efficacy against S. aureus.
The Combined Real-Time Global Ionospheric Maps for Precise GNSS Applications
Authors: Wang Ningbo , Li Zishen , Li Ang , Liu Ang
Published: August 2022

Benefiting from the global multi-frequency and multi-constellation GNSS measurements provided by the International GNSS Real-Time Service (IGS-RTS), real-time global ionospheric maps (RT-GIMs) have been provided by several ionospheric analysis centers of the International GNSS Service (IGS) since 2017. Considering the potential unstable ionospheric streams from individual analysis centers in real applications, we propose a sliding window based differential slant total electron content (dSTEC) weighting technique for the combination of Real-Time Global Ionospheric Maps (RT-GIMs). The combined RT-GIMs are generated using real-time ionospheric streams from the Chinese Academy of Sciences (CAS), Centre National d’Etudes Spatiales (CNES), Polytechnic University of Catalonia (UPC) and Wuhan University (WHU). The performance of combined RT-GIMs is validated in both ionospheric correction and positioning domains. The evaluation in the ionospheric correction domain is performed by comparison with the IGS final combined GIM, i.e. the IGS-GIM, as well as the independent ionospheric TEC observables derived from the Jason-3 altimetry and near-real-time DORIS observation data. The positioning performance of combined RT-GIMs is also evaluated in ionospheric corrected single-frequency standard point positioning (SF-SPP) and ionospheric constricted single-frequency precise point positioning (SF-PPP), by analyzing the 95% quantile of positioning residuals. Compared to IGS-GIM corrected results, the positioning accuracy of our combined RT-GIMs decreases by 5.1% and 6.8% in SF-SPP and SF-PPP analysis, respectively. When compared to BDGIM (the BDS-3 global broadcast ionospheric model) corrected results, the positioning accuracy of combined RT-GIMs increases by 17.2% in SF-SPP and 9.8% in SF-PPP, respectively. CAS combined RT-GIM streams are transmitted in both RTCM-SSR (IONO01IGS0) and IGS-SSR (IONO01IGS1) standards, which are accessible from the IGS (products.igs-ip.net:2101) casters since January 2022.
A report on JWG C.2: Quality control methods for climate applications of geodetic tropospheric parameters  
Authors: Santos Marcelo , Rees Jordan , Balidakis Kyriakos , Klos Anna , Pacione Rosa
Published: August 2022

We have been analyzing the ZTD time series estimated from six REPRO3 IGS Analysis Centers (ACs), namely, COD, ESA, GFZ, GRG, JPL, TUG, to compare their long-term trends. Long-term here means 20 years or longer. About thirty stations have been selected globally for this purpose. The estimated ZTD time series have gone through a process of homogenization using ERA-5 derived ZTDs as reference. The homogenized data is then averaged to daily values to minimize potential influences coming from different estimation strategies used by individual ACs. As mentioned, our interest is with the long-term signal. Similar averaging is applied to the ERA-5 ZTDs. Two combinations, using weighted mean and (a robust) least median of squares, are being generated from the six homogenized ACs. The combinations serve as quality control to each ACs. Analysis of the trends generated from each one of the seven ZTD times series is performed looking at their similarities in both time and frequency domains. This is a work in progress and the presentation will focus on the process and early results.
Natural hazard effects on ionospheric parameters detected by various space geodetic techniques
Authors: Alizadeh Mahdi , Foroodi Zahra , Rahmani Yaser , Schuh Harald
Published: August 2022

Natural hazards, that occur in the lower part of the Earth's atmosphere, the troposphere, are affecting higher atmosphere layers. Many of these phenomena, such as thunderstorms, heavy rainfalls, tsunamis, or volcanic eruptions create acoustic waves (AWs), and internal gravity waves (IGWs) in the atmosphere. These waves considerably affect the propagation of radio waves traveling through the ionosphere via transferring energy to this layer, causing significant variations in its parameters.

In this paper, IGWs generated by thunderstorms and tsunamis are investigated. For this task, we used double-frequency measurements from the Global Navigation Satellite Systems (GNSS) along with radio occultation (RO) measurements from Low Earth Orbiting (LEO) satellites, such as Formosat3/ COSMIC (F3/C) and SWARM.

The average increase of ionospheric irregularity amplitudes under severe thunderstorm conditions was 30% compared to calm conditions (non-lightning days). The Rate of TEC Index (ROTI) on high thunderstorm days showed an average increase of 25% within the lower ionosphere. In addition, a significant increase in amplitude and activity of IGWs and IAWs during the thunderstorms was observed.

In the case of tsunamis, the critical frequency of the F2 layer (foF2) showed clear disturbances at the GNSS ground stations due to the tsunami-generated IGWs. During the tsunami, the Ionospheric Electron Density (IED) decreased in altitudes below approximately 300km by 27%. However, above this height, the IEDs increased by 64% up to about 750 km altitude, with a maximum amount of 3.77 × 105 elec/cm3 at 355 km altitude. The average increase of ROTI during the arrival of the tsunami to the stations was 8%.

Keywords: Natural hazards, ionospheric parameters, thunderstorm, tsunami, internal gravity waves, troposphere-ionosphere vertical coupling.
Investigating the long-term variations of coordinate time series at co-located GNSS stations
Authors: Wang Jungang , Ge Maorong , Glaser Susanne , Heinkelmann Robert , Schuh Harald
Published: August 2022

Global Geodetic Observing System (GGOS) requires an accuracy of 1 mm and a stability of 1 mm/decade for the Terrestrial Reference Frame (TRF), which is not achieved yet. Global Navigation Satellite Systems (GNSS) play a critical role in TRF determination, thanks to its continuous observations collected from hundreds of globally distributed stations. GNSS observations at the user side are affected by antenna, receiver, and the local environment. The impact of the antenna is more significant to carrier-phase observations and handled with the phase center offset and variation corrections, meanwhile that of the receiver is more significant to the pseudo-range observations. In this study, we investigate the long-term agreement of station coordinates at co-located GNSS stations, i.e., more than one GNSS stations within a few hundreds of meters. We demonstrate that (1) the coordinate difference between co-located GNSS stations could have seasonal variations and long-term trends, (2) discontinuities are often observed after instrument changes, especially the antenna change, and (3) different receiver types could cause station coordinate bias up to 1 mm. A preliminary investigation of the possible reasons is carried out and addressed as well.