bluuebunny/crossref_metadata_2025 huggingface dataset:
Development of a method for determining the stability reserve of iron ore pit board section
Authors: Sidorenko V , Romanenko A , Panchenko V
Published: May 2021

The purpose of this article is to develop a new methodology for assessing the stability margin of iron ore opencast sides sections. The sequence of work. To achieve this goal, at the first stage, high-resolution photography was carried out for characteristic sections of the pit wall, followed by computer processing of photographs to assess the fracturing of rocks. The next step was the calculation of the fractal dimension of the array section from the obtained images using the ImageJ and FracLac programs, including the MicroMod2015 plug-in package (add-ons). The next step was assess the disturbance of the massif due to fracturing, a study of the relationship between the fractal dimension and the coefficient of structural weakening was carried out (this coefficient is determined by the classical method through the ratio of the strength of rocks in the massif and in the sample). At the last stage of the work, after establishing the specified connection and calculating the coefficient of structural weakening of rocks that based on the results of determining the fractal dimension, an assessment of the stability margin iron ore opencast sides sections that carried out. The known dependence of the stability safety factor on the coefficient of structural weakening of the array was used. As a result of comparing the fractal dimension of the exposed massif areas based on photographs with the calculation by classical methods, the discrepancy in the structural attenuation coefficient was 5-10%. This indicates a satisfactory convergence and allows the use of this express technique for assessing the fracturing of a section of a pit flank on the basis of fractal dimension. The scientific novelty of the results obtained - for the first time, the analytical dependence of the structural weakening coefficient of rocks on the fractal dimension of the massif cracks was established, which made it possible to simplify the procedure for its calculation. The practical significanceof the work lies in the creation of a new methodology for assessing the stability margin of an iron ore opencast side sections that the basis of rock fractures fractal analysis.
Influence of breakages of cable groups on strength ofrubber-cable tractive-transporting element
Authors: Belmas I , Kolosov D , Dolgov O , Tantsura H , Onyshchenko S
Published: May 2021

Purpose. Development and justification of a method of analytical determination of a stress-strain state of a flat rubber-cable tractive-transporting element with breakages of continuity of cable groups in different cross-sections. Methodology of research is in development of a mathematical model of interaction of tractive-transporting element parts considering breakages of groups of random cables, construction of analytical solutions for determining dependencies of force distribution between cables and shear stresses in an elastic shell of a tractive-transporting element with random locations of breakages of cable groups in different cross-sections. Findings. A model of a flat rubber-cable tractive-transporting element with random locations of breakages of cable groups in different cross-sections is developed. Expressions that allow determining a stress-strain state of a flat rubber-cable tractive-transporting element of a hoisting and transporting machine with random locations of breakages of cable groups in different cross-sections are obtained analytically in a closed form. Strength conditions are formulated. Scientific novelty is in establishment of dependencies of interaction of disturbance fields of a stress-strain state of a rubber-cable tractive-transporting element with breakages of continuity of random cable groups in different cross-sections. It is established that disturbance fields caused by breakages of adjacent cables overlap when the breakages are located in one cross-section and there are less than three whole cables located between the broken cables. Disturbance fields also overlap when the same cable or the adjacent cable is broken in both cross-sections and the distance between cross-sections of breakage does not exceed the value, which depends on the design of a flat rubber-cable tractive-transporting element and mechanical properties of its components. Practical significance. The obtained algorithms and strength conditions allow determining a stress-strain state and preventing the breakage of the entire flat rubber-cable tractive-transporting element with breakages of cable groups in different cross-sections. These cross-sections can be: cross-section of the edge of a butt joint, where cables have breakages of continuity; cross-section, which includes the edge of an area of partial restoration of a tractive ability of the element, lost due to breakage of a cable; cross-section of cable or cable group breakage during operation. A possibility of establishing a stress-strain state and the strength conditions of a tractive-transporting element under such conditions allows reasonable determination of a possibility of its further operation in a hoisting and transporting machine.
Substantiation of research of diagnostic methods for variable section rope
Authors: Belmas I , Shvachka A
Published: May 2021

Purpose. The paper analyzes the diagnostic methods for ropes with variable cross-section. The rationale consists in increasing the level of efficiency, safety and identifying a reliable method for monitoring the condition, service life of mine hoisting installations with main rubber-cord ropes. Research methodology. The analytical research method was used when receiving signals arising from a cable break. It was found that certain types of defects in which signals arise and are transmitted to the sensor when the cable breaks. Research results. Based on these results, it was proposed to diagnose the ropes using electrical resistance and develop a device. So, diagnostics consists in applying voltage to the ends of the rope ropes according to the selected schemes and in a given sequence, establishing the magnitude of the current arising in the conductors that are supplied with voltage, analyzing certain currents, providing information about the state of the ropes and, if necessary, stopping the machine. The received signals can be used as diagnostic parameters when monitoring the condition of the rope ropes by a special system for automatic detection of rupture of rubber-rope ropes. Scientific novelty. Improving the safety of lifting machines, in particular elevators, can be achieved by providing continuous and automatic control of the traction of ropes - the integrity of their traction elements of the cables. It is known that the control system works with the formulation, transmission and processing of the signal. The dependences of the resistance value as a diagnostic parameter of the system for monitoring the state of the main rubber-cord rope, during operation on a mine hoist, have been clarified, which make it possible to determine the currents arising in the ropes at the points of supply of the potential difference for a rope with intact ropes and in case of damage and automatically monitor the integrity of the rope base of the rope, than to increase the safety of operation of mine hoisting complexes. Practical value. The effective norms of exploitation of rubber cord hoisting ropes have been determined; the parameters of the control system for diagnostics of integrity have been substantiated and methods for monitoring the technical condition of ropes have been developed, protected by patents for invention.
Intellectual agents of targets in analytical constructing of optimum systems of management of drum mills
Authors: Meshcheriakov L , Kozhevnykov A , Prykhodchenko S
Published: May 2021

Purpose. Justification of the rational use of intellectual agents in forming of the quasi-optimal systems of management furnaces of complexes of type drum mills as observers of complete order. A method of research consists of decision of the best laws management by the mining complexes by the use of methods of the analytical constructing of optimum regulators withthe input in their structures of such essences as intellectual agents as observers of complete order. Results of research. Management by the mining and processing complexes it is perspective to carry out on the basis of the quasi-optimal systems of management. Taking into account properties and sensitiveness of intellectual agents, expediently to include them at the analytical constructing of regulators in the structure of observers of complete order. This increases in accordance with securing functional of quality criterion of exactness of optimum stabilization of rational technology of process of growing shallow in the drum mills. Scientific novelty. A new structure is set of the quasi-optimal system of management by the technological dynamics of drum mills with the asymptotic observer of complete order. Of efficiency of recognition and operative management it is suggested to carry the rise out on the basis of functional possibilities of intellectual agents of targets, as which an observer comes forward of complete order in aggregate with the considered technological processes in the mining and processing complexes. Practical value. Results of researches allow to recommend a rational chart of quasi-optimal management by the drum mills in accordance with the set criterion. In the spectrum of the active power consumable by the drive electric motor technological constituents are selected, which are conditioned by the difficult vibrations of ore mass of filling of drum. Their maximal values are selected ekstremum by detector and are watched by the observer of complete order with the optimum stabilization. This allows to secure intensification of return of the prepared class.
Implementasi Aplikasi Covid-19 Dalam Rangka Sosialisasi Terhadap Masyarakat Desa Padasuka
Authors:   Sekolah Tinggi Teknologi Garut, Alamsyah Renaldy , Safei P M Iqbal Ismail , Rajab Ilham Syahidatul , Wahidah Tania Agusviani , Helmalia P Nabilla Febriani , Kurniadi Dede
Published: May 2021

Pandemi COVID-19 membuat banyak negara menyusun kebijakan untuk menghindari warga yang tertular bisa turun. Tiap harinya jumlah kasus positif di Indonesia terus bertambah. Kurang pahamnya masyarakat akan pandemi COVID-19 menjadi dasar untuk mengampanyekan pencegahan penyebaran COVID-19 sesuai arahan pemerintah yang dilakukan oleh perguruan tinggi melalui kegiatan Kuliah Kerja Nyata. Upaya yang dilakukan agar mencegah penyebarannya adalah dengan edukasi mengenai cuci tangan, pakai masker, jaga jarak, dan tetap bersih. Kemudian pembuatan aplikasi Pusat Informasi COVID-19 Padasuka agar masyarakat lebih mudah untuk mendapatkan informasi dan bisa melakukan check-up secara mandiri. Hasil yang didapat dari kegiatan Kuliah Kerja Nyata ini yaitu para pelajar sekolah dasar menjadi lebih paham akan pentingnya mematuhi protokol kesehatan serta masyarakat khususnya perangkat desa bisa menggunakan aplikasi ini sebagai upaya untuk mencari informasi dan dapat melakukan check-up mandiri bisa mengetahui tertular COVID-19 atau tidak secara dini.
Análisis de la normativa legal y jurídica del modelo de gestión integral de instituciones de educación superior para el fortalecimiento de la calidad pedagógica
Authors: Sánchez-Chávez Roberto , Basantes-Avalos Jenny , Falconí-Tello María , Vallejo-Lucio Yadira
Published: May 2021

Este estudio tiene el objetivo de conocer los beneficios que genera la implementación del plan toda una vida dentro del sistema educativo dentro de la educación superior. En medio de la investigación se estudió el nivel de enseñanza de los docentes para lograr mejorar las técnicas de estudio orientándolas más a esta nueva técnica. El método investigativo utilizado fue descriptivo, exploratorio y no experimental, por medio de un estudio de campo mediante la aplicación de encuestas debidamente estructuradas, a docentes universitarios. Los resultados revelan que, esta aplicación traerá mejoras no solo a nivel general si no también integral de los estudiantes permitiéndolos desarrollarse en un ambiente sano en el que se respeten sus decisiones y opiniones acerca de resoluciones que existan en la universidad.
EL COVID 19 y su impacto financiero en el sector florícola ecuatoriano. Análisis comparativo
Authors: Morocho-Aguirre Nestor , Cisneros-Aliaga Mileysha , Soto-Gonzalez Carlos
Published: May 2021

El Ecuador es uno de los países que encabeza la lista de las exportaciones de flores, puesto que es un país netamente agrícola, consolidándose este sector como uno de los rubros más significativos para el ingreso de divisas al país. Ecuador es el tercer país exportador de flores a nivel mundial satisfaciendo el 9,7% de la demanda global de flores. Es por ello que el presente trabajo tiene como objetivo analizar los efectos del COVID-19, mediante un estudio comparativo de las exportaciones florícolas para conocer el impacto financiero en el periodo Enero-octubre de 2019 a enero-octubre de 2020. La presente investigación emplea una metodología cualitativa debido a que utilizamos referencias bibliográficas de varios autores para fundamentar la investigación, además se recopilo datos de las exportaciones florícolas para comprobar los efectos del Covid-19 en este sector. De los datos obtenidos tuvimos como resultado que el sector florícola tuvo una disminución de las exportaciones de flores de 7,39% en 2020 en comparación con el año anterior, esto se debe a la crisis económica ocasionada por la pandemia mundial por la escasa demanda, además de la paralización de las jornadas laborales y los cierres de mercados.
Bir araştırma yöntemi olarak doküman analizi
Authors: SAK Ramazan , ŞAHİN SAK İkbal Tuba , ÖNEREN ŞENDİL Çağla , NAS Eşref
Published: May 2021

Doküman analizi, araştırma verilerinin birincil kaynağı olarak çeşitli dokümanların toplanması, gözden geçirilmesi, sorgulanması ve analizi olarak tanımlanabilen bilimsel bir araştırma yöntemidir. Bu yöntem, alanyazında çoğunlukla diğer araştırma yöntemlerinin tamamlayıcısı olarak hizmet ederken, tek başına bir yöntem olarak da kullanılmaktadır. Sosyal bilimlerde çalışma yöntemi olarak doküman analizinin kullanıldığı araştırmaların sayısında bir artış göze çarpmaktadır. Bu artışa rağmen diğer yöntemlerle karşılaştırıldığında doküman analizinin kullanımının oldukça sınırlı olduğu söylenebilir. Doküman analizinin bir araştırma yöntemi olarak birçok avantajı olmasına rağmen az kullanılmasının sebeplerinden birinin bu yöntem hakkındaki bilgi yetersizliği olduğu düşünülmektedir. Bir araştırma yöntemi olarak doküman analizi hakkında daha detaylı bilgilere ihtiyaç duyulmaktadır. Bu nedenle bu çalışmada doküman analizinin tanımı, mantığı, aşamaları, avantajları ve dezavantajlarının ortaya konulması amaçlanmıştır. Bununla birlikte, doküman analizine ilişkin bazı yanlış çıkarımlar söz konusudur. Buradan yola çıkarak bu çalışma kapsamında, (1) doküman analizi bir araştırma yöntemi mi, bir nitel veri toplama tekniği mi yoksa bir nitel veri analiz yöntemi mi, (2) yöntem çeşitlemesi (triangulation) ile veri çeşitlemesi aynı şey mi ve (3) doküman analizinin kullanıldığı bir araştırma bir alanyazın taraması mı tartışmalarına değinilmiştir. Ayrıca, doküman analizi yönteminde geçerlik ve güvenirliği sağlamak için dokümanları yalnızca incelemek yerine, kaynağı ve oluşma biçimiyle birlikte yorumlamaya çalışmak, dokümanlardan çıkarılan sonuçları farklı kaynaklardan doğrulamak ve gerektiğinde doküman analizi dışındaki yöntemleri de kullanmak ve bütün araştırma yöntemlerinde olduğu gibi doküman analizinde de araştırma standartlarına ve etiğe sıkı sıkıya bağlı kalmak gerektiği üzerinde durulmuştur.
STUDI AWAL MOTIVASI BELAJAR MAHASISWA PENDIDIKAN GURU SEKOLAH DASAR (PGSD) PADA MATA KULIAH KONSEP DASAR IPA
Authors: Yanti Yulia Eka
Published: May 2021

Motivasi merupakan salah satu faktor utama yang mempengaruhi keberhasilan atau kegagalan dalam pembelajaran dan pengajaran Salah satu pendekatan yang dapat digunakan untuk mengetahui tingkat motivasi belajar mahasiswa yaitu model ARCS. Empat aspek yang menjadi bagian penyusun motivasi tersebut adalah aspek attention, relevance, confidence, dan satisfaction. Tujuan penelitian ini adalah untuk mengetahui mengetahui tingkat motivasi belajar mahasiswa S1 PGSD Universitas Islam Raden Rahmat pada Mata Kuliah Konsep Dasar IPA. Jenis penelitian ini adalah penelitian deskriptif kuantitatif dengan metode survei, dalam hal ini menggunakan angket motivasi mahasiswa. Subjek penelitian adalah terdiri dari empat kelas dengan total 76 mahasiswa pada Prodi PGSD dan PGMI Universitas Islam Raden Rahmat. Hasil penelitian menunjukkan bahwa motivasi belajar mahasiswa PGSD pada aspek attention dan relevance berada pada kategori cukup sedangkan untuk aspek confidence dan satisfaction berada pada kategori tinggi. Namun demikian, motivasi belajar mahasiswa pada mata kuliah Konsep Dasar IPA masih perlu ditingkatkan.
Mewujudkan Pedagang Aman COVID-19 dengan 3M pada Pandemi COVID-19 Di Kota Bontang
Authors: Permana Lies , Helwena Helwena
Published: May 2021

In October 2020, it was found that the largest number of clusters for the spread of COVID-19 were family clusters, namely 37 clusters in Bontang City, East Kalimantan. In addition, cases of COVID-19 were also found originating from traders in the night market. Judging from the COVID-19 cases, the risk from traders who have shophouses as well as their living quarters with other family members is very vulnerable to the spread of COVID-19. This community service aims to increase knowledge and raise awareness of merchants about the 3M movements. A service was carried out by providing 3M programs to prevent COVID-19, distributing cloth masks according to standards, distributing media posters, and providing hand wash facilities in the merchant area. The target of this service is ten traders who own shop houses. There is an effect of counseling on increasing the knowledge of 10 traders who have shop houses in the Berbas Night Market area. All masks are distributed to all respondents. There is a media feed back that is shared for increasing knowledge. The availability a washing hands fasilities. There are three programs implemented in community service to prevent COVID-19 in traders in the Berbas night market area.
Implementasi Sistem Informasi Desa (SID) untuk Peningkatan Layanan dan Keterbukaan Informasi di Desa Hulosobo, Kaligesing, Purworejo
Authors: Susanto Ajib , Rachmawanto Eko Hari , Mulyono Ibnu Utomo Wahyu , Sari Christy Atika
Published: May 2021

Saat ini pedesaan adalah salah satu sektor yang diperhatikan pemerintah dengan diberikan anggaran desa 10% dari APBN. Implementasi pemberian dana di desa Provinsi Jawa Tengah mencapai 1 Milyar tiap desa, hal ini akan menimbulkan kerawanan untuk diselewengkan sehingga membutuhkan transparansi salah satunya dengan memberikan informasi yang up to date melalui media online. Berbagai informasi yang dimiliki desa belum dapat disampaikan secara langsung, baik informasi pembangunan, UMKM, kegiatan PKK, kegiatan pemuda dan promosi desa, sehingga sangat dibutuhkan media yang dapat mengatasi hal tersebut, permasalahan ini dapat diselesaikan salah satunya dengan membuat website desa. Pengembangan web desa dengan menggunakan framework Sistem Informasi Desa (SID) dengan tahapan analisis kebutuhan, perancangan, instalasi SID dan hosting, implementasi dan evaluasi. Hasil implementasi SID terwujud web desa yang dapat memberikan layanan dan keterbukaan informasi desa ke seluruh warga desa
IDIOPATHIC ISOLATED HYPOGLOSSAL NERVE PALSY: CASE REPORT
Authors: Tetik Selim , Güven Oya , Çoban Mehmet
Published: May 2021

Abstract
Introduction: The hypoglossal nerve (xii. Nerve) in the central bulbus contains only motor fibers. After leaving the brain stem, the fibers coming out of it pass through the canalis hypoglossis in the occipital bone and move to the parafarengeal cavity and then to the level of the occipital artery, reaching the suprahioid region. It passes behind the milohyoid and hyoglossus muscles and reaches the intrinsic muscles of the tongue. In addition, stylolossus innervates the hyoglossus and genioglossus muscles.
Case Report: A 16-year-old female patient addmited to our emergency room with the complaint of her tongue turning left (not rotating) in her mouth for 3 days, no head injury. Brain examinations and tests were normal. She got better with antipsychotic, dopaminergic, anticholinergic treatment.
Conclusion: We are in this article; We tried to investigate rare idiopathic hypoglossal nerve palsy causes with the literature.
A Rare Thyroid Gland Emergency: Thyroid Abscess
Authors: Artaş Hakan , Eroğlu Yeşim
Published: May 2021

Introduction
Thyroid abscess is a serious head and neck infection that may easily be overlooked. The thyroid gland is resistant to infections due to its rich blood supply, good lymphatic drainage, high iodine content and a solid capsule. Therefore, thyroid abscess is a rare disease with serious complications when the diagnosis is delayed. In this paper, we present a case of thyroid abscess who presented with fever, fatigue, neck pain and swelling, and rapidly deteriorated general condition.
Case Report
A 28-year-old female patient had painful swelling and redness on the left side of the neck. She had fever, fatigue, and dysphagia. Laboratory tests revealed leukocytosis, elevated CRP, and sedimentation rate. The patient who was detected to have thyroid abscess on ultra-sonography and computed tomography was discharged with recovery through surgery and appropriate antibio-therapy.
Conclusion
Thyroid gland abscess is a rare, serious clinical condition with high morbidity and mortality. Thyroid abscess should be kept in mind while performing radiological evaluation in cases presenting with swelling and redness in the neck. In these cases, quite good clinical outcomes may be achieved with early diagnosis and appropriate treatment.
Magnetic Resonance Imaging Findings in Status Epilepticus: A Case Report
Authors: Barutcu Asfuroğlu Berrak , Ünsal Yaprak Özüm , Asfuroğlu Umut , Koc Ali Murat
Published: May 2021

Introduction: Status epilepticus (SE) is a neurological emergency in which prolonged seizures require rapid diagnosis and treatment. It is classified as convulsive, non-convulsive, and electrographic patterns. Neuroimaging findings associated with status epilepticus may raise suspicion of ischemia, encephalitis, or neoplastic lesions possibly leading to additional studies and surgical treatment. Further follow-up imaging may prevent unnecessary intervention due to findings in status epilepticus may be reversible. Case Report: We report a case of convulsive status epilepticus with electroencephalography and cranial magnetic resonance imaging (MRI) findings discussing differential diagnosis. Conclusion: Our case highlights that SE should be aware of this potentially fatal condition and start the treatment immediately.
A Rare Cause of the Emergency Department Visit: Internal Jugular Vein Thrombosis
Authors: Akdur Gökhan , Bardakcı Okan , Akdur Okhan , Daş Murat , Atalay Unzile
Published: May 2021

Introduction
Detection of the internal jugular vein thrombus (IJVT) in the Emergency Department with bedside ultrasonography is not common.
Case Report
A 43 years old male patient was admitted to our emergency department with the complaint of pain, swelling and redness on the left side of the neck, which was noticed after chemotherapy 1 day ago. The swelling and redness of the hand, starting from the left clavicle and extending to the corner of the left mandible, were detected in the physical examination of the patient. The patient underwent bedside ultrasonography imaging by the emergency medicine specialist. Ultrasonography examination of the patient was performed with 5-12 MHz linear probe. After visualization of the vascular structures carotid, vascular structures were observed in the sagittal and longitudinal plane by gradual compression. Hyper echoic thrombus was seen in the incompressible internal jugular vein.
Conclusion
IJVT can lead to complications such as pulmonary embolism, septic embolism, cerebral venous thrombosis. These complications may decrease with early diagnosis and treatment. It is a rare condition in IJVT Emergency Services. The increasing use of bedside ultrasonography by emergency physicians will prevent possible complications that will enable these patients to be easily diagnosed and successful treatments in recent years.
A RARE EFFECT OF COVID-19: CEREBRAL VENOUS SINUS THROMBOSIS CASE PRESENTATION
Authors: Kurt Bedriye Feyza , Kurt Erman , Güven Oya , Kaşıkeman Okay
Published: May 2021

Introduction: Many studies have shown that coagulation disorders and increased risk of thrombosis may occur during coronavirus disease 2019 (COVID-19) infection. Although cardiac or pulmonary vascular pathologies has been detected in most cases, cerebral sinus thrombosis are rare. During COVID-19 infection patients rarely present with neurological symptoms.
Case Report: A 19-year-old man was admitted to our emergency department with neurological symptoms. Cerebral venous sinus thrombosis (CVST) was detected in Brain Computerized Tomography and Magnetic Resonance Imaging examinations. Our patient was hospitalized in the neurology department of our hospital for medical treatment and was discharged after clinical recovery
Discussion: In this case report we wanted to draw attention to cerebral venous sinus thrombosis which is a rare but treatable complication of COVID-19 infection in a young patient. We examined our patient in the light of literature.
Conclusion: Clinicians should keep in mind the diagnosis of CVST that may occur due to infection associated thrombosis in COVID-19 patients presenting with neurological symptoms and consider adding anticoagulants to the treatment if necessary.
IMAGE OF WOMEN IN GADIS KRETEK NOVEL BY RATIH KUMALA BASED ON FEMINISM PERSPECTIVE
Authors: Suhendra Suhendra , Mahajani Tri , Nurjaman Aam , Talitha Stella , Hilal M Ruyatul , Lestari Tania
Published: May 2021

Novel is part of a literary work that contains a series of life stories of characters and people around them. The portrayal of character is described by an arranged series of events, setting, and furrows. It aims to examine a women’s image in the feminism perspective of a Gadis Kretek novel. The feminism perspective in the writing is focused on the image of women embracing the physical image of a woman’s physical transformation. Psychic image, linked to the ability of women to think, to aspire, and to feel. Image in the family, concerning the roles of women in the family. Image in society can be demonstrated by the female role in society embodied in behavior. This research used a qualitative descriptive method with library study techniques. The conclusion of this study shows that the image of female physis is more characterized by the physical depiction of the main character from aspects of age, maturity, and behavior like adults. Psychic imagery is depicted through the permmature of thinking in a mature figure. The image in the family appears to be attached to the main character who plays a child. The image in society is characterized by the role of the main character portrayed as an intelligent, independent, responsible, and cheerful woman.
The Robin Inequality On Certain Numbers
Authors: Vega Frank
Published: May 2021

In mathematics, the Riemann hypothesis is a conjecture that the Riemann zeta function has its zeros only at the negative even integers and complex numbers with real part $\frac{1}{2}$. In 1915, Ramanujan proved that under the assumption of the Riemann hypothesis, the inequality $\sigma(n) < e^{\gamma } \times n \times \log \log n$ holds for all sufficiently large $n$, where $\sigma(n)$ is the sum-of-divisors function and $\gamma \approx 0.57721$ is the Euler-Mascheroni constant. In 1984, Guy Robin proved that the inequality is true for all $n > 5040$ if and only if the Riemann hypothesis is true. Since then, this is called as the Robin inequality. It is known that the Robin inequality is satisfied for many classes of numbers. We show more classes of numbers for which the Robin inequality is always satisfied.
What can we learn from COVID-19 as a form of public pedagogy?
Authors: Bengtsson Stefan , Van Poeck Katrien
Published: May 2021

This paper aims to investigate the corona-crisis as a large-scale, unplanned and unintended global experiment of ‘public pedagogy’. An investigation is focused on touching upon emergent questions such as: What does our experience of the crisis brought about by the emergence of this specific virus tell us about our assumptions of learning and of public engagement with an issue as a form of public pedagogy? We bring into play transactional theory of teaching and learning, as well as Jan Masschelein’s notion of pedagogical milieu of study and Timothy Morton’s concept of hyperobject to conceptualize what we can learn from COVID-19 in terms of teaching and learning.
Fatores que influenciam a não aplicabilidade do atletismo nas aulas de Educação Física
Authors: Ribas Raquel Dumas , Guimarães Amanda Jalloul , Consalter Iuna , Santos Aguinaldo Souza dos , Marthins Adriana Gallego
Published: May 2021

A pesquisa teve como objetivo, identificar os fatores que influenciam a não aplicabilidade do atletismo nas aulas de Educação Física. A metodologia adotada foi a revisão sistemática, buscando artigos entre os anos de 2008 e 2019, em oito bases de buscas: BVS, SBU, SciELO, PBi, Redalyc, Lilacs, ScienceDirect e Periódicos Capes. Foram selecionados os artigos em que pudessem ser extraídas essas informações, resultando em oito estudos relevantes. A maioria dos artigos apontou a falta de materiais e de espaço físico, como principais fatores que dificultam a aplicabilidade do atletismo nas aulas de Educação Física. E ainda, os autores ressaltaram que essas dificuldades não poderiam interferir no desenvolvimento dessa modalidade nas aulas. Concluiu-se com este estudo que o professor é o mediador entre o conhecimento e os alunos, e cabe a ele sair da sua zona de conforto para buscar caminhos para superar os obstáculos, e aplicar os conteúdos da modalidade de atletismo, fazendo uso da ludicidade como um instrumento no ensino da educação física escolar.
PARP1 Regulates the Biogenesis and Activity of Telomerase Complex Through Modification of H/ACA-Proteins
Authors: Savelyev Nikita V. , Shepelev Nikita M. , Lavrik Olga I. , Rubtsova Maria P. , Dontsova Olga A.
Published: May 2021

Poly(ADP-ribose) polymerase 1 (PARP1) is established as a key regulator of the cellular DNA damage response and apoptosis. In addition, PARP1 participates in the global regulation of DNA repair, transcription, telomere maintenance, and inflammation response by modulating various DNA-protein and protein-protein interactions. Recently, it was reported that PARP1 also influences splicing and ribosomal RNA biogenesis. The H/ACA ribonucleoprotein complex is involved in a variety of cellular processes such as RNA maturation. It contains non-coding RNAs with specific H/ACA domains and four proteins: dyskerin (DKC1), GAR1, NHP2, and NOP10. Two of these proteins, DKC1 and GAR1, are targets of poly(ADP-ribosyl)ation catalyzed by PARP1. The H/ACA RNA-binding proteins are involved in the regulation of maturation and activity of the telomerase complex, which maintains telomere length. In this study, we demonstrated that of poly(ADP-ribosyl)ation influences on RNA-binding properties of DKC1 and GAR1 and telomerase assembly and activity. Our data provide the evidence that poly(ADP-ribosyl)ation regulates telomerase complex assembly and activity, in turn regulating telomere length that may be useful for design and development of anticancer therapeutic approaches that are based on the inhibition of PARP1 and telomerase activities.
Emerging Role of m6 A Methylome in Brain Development: Implications for Neurological Disorders and Potential Treatment
Authors: Sokpor Godwin , Xie Yuanbin , Nguyen Huu P. , Tuoc Tran
Published: May 2021

Dynamic modification of RNA affords proximal regulation of gene expression triggered by non-genomic or environmental changes. One such epitranscriptomic alteration in RNA metabolism is the installation of a methyl group on adenosine [N6-methyladenosine (m6A)] known to be the most prevalent modified state of messenger RNA (mRNA) in the mammalian cell. The methylation machinery responsible for the dynamic deposition and recognition of m6A on mRNA is composed of subunits that play specific roles, including reading, writing, and erasing of m6A marks on mRNA to influence gene expression. As a result, peculiar cellular perturbations have been linked to dysregulation of components of the mRNA methylation machinery or its cofactors. It is increasingly clear that neural tissues/cells, especially in the brain, make the most of m6A modification in maintaining normal morphology and function. Neurons in particular display dynamic distribution of m6A marks during development and in adulthood. Interestingly, such dynamic m6A patterns are responsive to external cues and experience. Specific disturbances in the neural m6A landscape lead to anomalous phenotypes, including aberrant stem/progenitor cell proliferation and differentiation, defective cell fate choices, and abnormal synaptogenesis. Such m6A-linked neural perturbations may singularly or together have implications for syndromic or non-syndromic neurological diseases, given that most RNAs in the brain are enriched with m6A tags. Here, we review the current perspectives on the m6A machinery and function, its role in brain development and possible association with brain disorders, and the prospects of applying the clustered regularly interspaced short palindromic repeats (CRISPR)–dCas13b system to obviate m6A-related neurological anomalies.
Roles of Dental Mesenchymal Stem Cells in the Management of Immature Necrotic Permanent Teeth
Authors: Cui Dixin , Yu Sihan , Zhou Xin , Liu Ying , Gan Lu , Pan Yue , Zheng Liwei , Wan Mian
Published: May 2021

Dental caries and trauma always lead to pulp necrosis and subsequent root development arrest of young permanent teeth. The traditional treatment, apexification, with the absence of further root formation, results in abnormal root morphology and compromises long-term prognosis. Regeneration endodontics procedures (REPs) have been developed and considered as an alternative strategy for management of immature permanent teeth with pulpal necrosis, including cell-free and cell-based REPs. Cell-free REPs, including revascularization and cell homing with molecules recruiting endogenous mesenchymal stem cells (MSCs), have been widely applied in clinical treatment, showing optimistic periapical lesion healing and continued root development. However, the regenerated pulp–dentin complex is still absent in these cases. Dental MSCs, as one of the essentials of tissue engineering, are vital seed cells in regenerative medicine. Dental MSC–based REPs have presented promising potential with pulp–dentin regeneration in large animal studies and clinical trials via cell transplantation. In the present review, we summarize current understanding of the biological basis of clinical treatments for immature necrotic permanent teeth and the roles of dental MSCs during this process and update the progress of MSC-based REPs in the administration of immature necrotic permanent teeth.
DCBLD2 Affects the Development of Colorectal Cancer via EMT and Angiogenesis and Modulates 5-FU Drug Resistance
Authors: Xie Pan , Yuan Fu-Qiang , Huang Ma-Sha , Zhang Wei , Zhou Hong-Hao , Li Xi , Liu Zhao-Qian
Published: May 2021

Background: DCBLD2 is highly expressed in various cancers, including colorectal cancer. DCBLD2 overexpression promotes tumor occurrence, development, and metastasis. However, DCBLD2 sensitivity to chemotherapy drugs and its mechanism on tumor development are unknown.

Methods: DCBLD2 expression differences in cancer and normal tissues were obtained from GEO and TCGA databases. DCBLD2 influence on prognosis was also compared, and the database analysis results were verified via the analysis of clinical samples. GDSC database was used to analyze the effect of DCBLD2 expression difference on 5-FU drug sensitivity on tumor cells. CCK-8, clone formation, scratch, Transwell invasion and migration assays were used to assess DCBLD2 effects on the proliferation, metastasis, and 5-FU drug sensitivity on HCT116 and Caco-2 colorectal cancer cells. Angiogenesis and Matrigel plug assays were used to study the effect of DCBLD2 on angiogenesis. Q-RCR and Western Blot were used to analyze DCBLD2 impact on the EMT signaling pathway, and TAP-MS assay with Co-IP verification was used to identify the downstream target proteins binding to DCBLD2.

Results: Both database and clinical sample validation results showed that the expression of DCBLD2 in colorectal cancer tissues was significantly higher than that in normal tissues, leading to poor prognosis of patients. GDSC database analysis showed that DCBLD2 overexpression caused tumor cell resistance to 5-FU. The results of in vitro and in vivo experiments showed that the inhibition of DCBLD2 reduced the proliferation, migration and invasion of colorectal cancer cells, inhibited the angiogenesis of endothelial cells, and enhanced the drug sensitivity to 5-FU. The results of q-RCR and Western Blot experiments showed that the inhibition of DCBLD2 can suppress the EMT signal. The results of TAP-MS assay showed that the proteins bound to DCBLD2 were enriched to the Focal adhesion pathway. The results of Co-IP assay show that DCBLD2 can combine with ITGB1, the key factor of Focal adhesion pathway.

Conclusion: DCBLD2 may affect the development of colorectal cancer by regulating cell proliferation and motility, and modulate 5-FU resistance. Down-regulation of DCBLD2 can inhibit EMT signal and angiogenesis. DCBLD2 can combine with ITGB1, the key signal factor of the Focal adhesion pathway.
Podophyllotoxin Exposure Affects Organelle Distribution and Functions in Mouse Oocyte Meiosis
Authors: Lu Ping-Shuang , Xie Lan-Ping , Kong Xiao-Han , Xu Yi , Sun Shao-Chen
Published: May 2021

Podophyllotoxin (POD) is one of the most characterized lignans that is commonly found in podophyllum, and its preparations and derivatives are widely used in clinical treatment due to strong antitumor and antivirus activities. POD has been reported for its neurotoxicity, liver toxicity, and potential reproductive toxicity. In the present study, we investigated the effects of POD on the organelles of mouse oocytes during meiosis. Our results showed that exposure to POD significantly reduced the developmental competence of mouse oocytes. Further analysis revealed that the endoplasmic reticulum (ER) failed to accumulate to the spindle periphery, suggesting that POD exposure might affect protein synthesis during oocyte meiotic maturation. Similarly, abnormal Golgi apparatus distribution was found after POD exposure, which could be confirmed by the aberrant localization of Rab11a-related vesicles, indicating that POD induced vesicle-based protein transport disorder. We also found the aberrant accumulation of lysosomes in the cytoplasm of POD-exposed oocytes, which implied that POD might lead to aberrant protein degradation. Moreover, the perinuclear distribution of mitochondria was also significantly disturbed, indicating the mitochondrial dysfunction after POD exposure. In all, our study illustrated that exposure to POD might disrupt protein synthesis, transport, degradation, and ATP production by its effects on the distribution and functions of organelles during mouse oocyte meiotic maturation.
A Prognostic Ferroptosis-Related lncRNAs Signature Associated With Immune Landscape and Radiotherapy Response in Glioma
Authors: Zheng Jianglin , Zhou Zijie , Qiu Yue , Wang Minjie , Yu Hao , Wu Zhipeng , Wang Xuan , Jiang Xiaobing
Published: May 2021

Recent studies have demonstrated that long non-coding RNAs (lncRNAs) are implicated in the regulation of tumor cell ferroptosis. However, the prognostic value of ferroptosis-related lncRNAs has never been comprehensively explored in glioma. In this study, the transcriptomic data and clinical information of glioma patients were downloaded from TCGA, CGGA and Rembrandt databases. We identified 24 prognostic ferroptosis-related lncRNAs, 15 of which (SNAI3-AS1, GDNF-AS1, WDFY3-AS2, CPB2-AS1, WAC-AS1, SLC25A21-AS1, ARHGEF26-AS1, LINC00641, LINC00844, MIR155HG, MIR22HG, PVT1, SNHG18, PAXIP1-AS2, and SBF2-AS1) were used to construct a ferroptosis-related lncRNAs signature (FRLS) according to the least absolute shrinkage and selection operator (LASSO) regression. The validity of this FRLS was verified in training (TCGA) and validation (CGGA and Rembrandt) cohorts, respectively. The Kaplan-Meier curves revealed a significant distinction of overall survival (OS) between the high- and low-risk groups. The receiver operating characteristic (ROC) curves exhibited robust prognostic capacity of this FRLS. A nomogram with improved accuracy for predicting OS was established based on independent prognostic factors (FRLS, age, and WHO grade). Besides, patients in the high-risk group had higher immune, stroma, and ESTIMATE scores, lower tumor purity, higher infiltration of immunosuppressive cells, and higher expression of immune checkpoints. Patients in the low-risk group benefited significantly from radiotherapy, while no survival benefit of radiotherapy was observed for those in the high-risk group. In conclusion, we identified the prognostic ferroptosis-related lncRNAs in glioma, and constructed a prognostic signature which was associated with the immune landscape of glioma microenvironment and radiotherapy response.
Environmental Influences on Human Subsistence Strategies in Southwest China During the Bronze Age: A Case Study at the Jiangxifen Site in Yunnan
Authors: Lu Minxia , Li Xiaorui , Wei Wenyu , Lu Yiwen , Ren Lele , Ma Minmin
Published: May 2021

The study of human dietary structures is an effective means of elucidating the subsistence patterns of our prehistoric ancestors and can highlight the processes through which humans interacted with the environment. We conducted stable isotope and archeobotanical analyses of human, animal, and plant remains at the Jiangxifen site, dated to ~900–400 BC, to explore human paleodiets and determine the environmental adaptation strategies adopted by humans in the middle valley of the Jinshajiang River in Yunnan Province. Humans predominantly consumed C4 foods (e.g., millet) and C4 food-fed animal protein sources, with smaller contributions from C3 food plants (e.g., rice) and C3 food-fed animal protein sources. We argued that the local dry-hot environment was the reason for the accessibility of C4 plants in the studied area. A comparison of our results with previously published archeobotanical data and isotopic evidence from human bones in other Bronze Age sites in Yunnan Province revealed high spatial variability in diets of human and subsistence strategies during this period. These differences were caused by the highly varying living environment of each region, which was related to fragmentation resulting from the geomorphological features of Yunnan Province.
Solastalgic Landscapes: Prospects of Relocation in Coastal Louisiana
Authors: Simms Jessica R. Z.
Published: May 2021

Globally, rapid and slow-onset socio-environmental coastal disasters are prompting people to consider migrating inland. Climate change is exacerbating these disasters and the multi-faceted causal contributing factors, including land loss, livelihood shifts, and disintegration of social networks. Familiar with ongoing disruptive displacements, coastal Louisiana residents are now increasingly compelled to consider permanent relocation as a form of climate adaptation. This paper elicits and analyzes coastal Louisiana residents’ perceptions of socio-environmental changes as they pertain to relocation as adaptation and the precariousness of place, both biophysically and culturally. It investigates how these external mechanisms affect relocation decisions, and empirically expand on how these decision-making processes are affecting residents internally as well. Research methods include semi-structured interviews with coastal Louisiana residents, participant observation, and document analysis. The paper integrates literature on environmental migration, including climate-driven; regional studies on Louisiana, and disasters, with empirical, interview-based research. It is guided by theoretical insights from the construct “solastalgia,” the feeling of distress associated with environmental change close to one’s home. The findings suggest that residents’ migration decisions are always context-dependent and location-specific, contributing to a broader understanding of coastal residents’ experiences of staying or going.
Differentially Expressed Genes and Enriched Signaling Pathways in the Adipose Tissue of Obese People
Authors: Lu Zhenhua , Meng Lingbing , Sun Zhen , Shi Xiaolei , Shao Weiwei , Zheng Yangyang , Yao Xinglei , Song Jinghai
Published: May 2021

As the prevalence of obesity increases, so does the occurrence of obesity-related complications, such as cardiovascular and cerebrovascular diseases, diabetes, and some cancers. Increased adipose tissue is the main cause of harm in obesity. To better understand obesity and its related complications, we analyzed the mRNA expression profiles of adipose tissues from 126 patients with obesity and 275 non-obese controls. Using an integrated bioinformatics method, we explored the functions of 113 differentially expressed genes (DEGs) between them. Gene ontology (GO) and kyoto encyclopedia of genes and genomes (KEGG) pathway enrichment analyses revealed that upregulated DEGs were enriched in immune cell chemotaxis, complement-related cascade activation, and various inflammatory signaling pathways, while downregulated DEGs enriched in nutrient metabolism. The CIBERSORT algorithm indicated that an increase in macrophages may be the main cause of adipose tissue inflammation, while decreased γδ T cells reduce sympathetic action, leading to dysregulation of adipocyte thermogenesis. A protein-protein interaction network was constructed using the STRING database, and the top 10 hub genes were identified using the cytoHubba plug-in in Cytoscape. All were confirmed to be obesity-related using a separate dataset. In addition, we identified chemicals related to these hub genes that may contribute to obesity. In conclusion, we have successfully identified several hub genes in the development of obesity, which provide insights into the possible mechanisms controlling obesity and its related complications, as well as potential biomarkers and therapeutic targets for further research.