bluuebunny/crossref_metadata_2025 huggingface dataset:
Glucose Stimulates Gut Motility in Fasted and Fed Conditions: Potential Involvement of a Nitric Oxide Pathway
Authors: Wemelle Eve , Carneiro Lionel , Abot Anne , Lesage Jean , Cani Patrice D. , Knauf Claude
Published: May 2022

(1) Background: Type 2 diabetes (T2D) is associated with a duodenal hypermotility in postprandial conditions that favors hyperglycemia and insulin resistance via the gut-brain axis. Enterosynes, molecules produced within the gut with effects on the enteric nervous system, have been recently discovered and pointed to as potential key modulators of the glycemia. Indeed, targeting the enteric nervous system that controls gut motility is now considered as an innovative therapeutic way in T2D to limit intestinal glucose absorption and restore the gut-brain axis to improve insulin sensitivity. So far, little is known about the role of glucose on duodenal contraction in fasted and fed states in normal and diabetic conditions. The aim of the present study was thus to investigate these effects in adult mice. (2) Methods: Gene-expression level of glucose transporters (SGLT-1 and GLUT2) were quantified in the duodenum and jejunum of normal and diabetic mice fed with an HFD. The effect of glucose at different concentrations on duodenal and jejunal motility was studied ex vivo using an isotonic sensor in fasted and fed conditions in both normal chow and HFD mice. (3) Results: Both SGLT1 and GLUT2 expressions were increased in the duodenum (47 and 300%, respectively) and jejunum (75% for GLUT2) of T2D mice. We observed that glucose stimulates intestinal motility in fasted (200%) and fed (400%) control mice via GLUT2 by decreasing enteric nitric oxide release (by 600%), a neurotransmitter that inhibits gut contractions. This effect was not observed in diabetic mice, suggesting that glucose sensing and mechanosensing are altered during T2D. (4) Conclusions: Glucose acts as an enterosyne to control intestinal motility and glucose absorption through the enteric nervous system. Our data demonstrate that GLUT2 and a reduction of NO production could both be involved in this stimulatory contracting effect.
Investigations on the Efficacy of Ozone as an Environmental Sanitizer in Large Supermarkets
Authors: Caggiano Giuseppina , Lopuzzo Marco , Spagnuolo Valentina , Diella Giusy , Triggiano Francesco , D’Ambrosio Marilena , Trerotoli Paolo , Marcotrigiano Vincenzo , Barbuti Giovanna , Sorrenti Giovanni Trifone , Magarelli Pantaleo , Sorrenti Domenico Pio , Napoli Christian , Montagna Maria Teresa
Published: May 2022

Awareness of the importance of the microbial contamination of air and surfaces has increased significantly during the COVID-19 pandemic. The aim of this study was to evaluate the presence of bacteria and fungi in the air and on surfaces within some critical areas of large supermarkets with and without an ozonation system. Surveys were conducted in four supermarkets belonging to the same commercial chain of an Apulian city in June 2021, of which two (A and B) were equipped with an ozonation system, and two (C and D) did not have any air-diffused remediation treatment. There was a statistically significant difference in the total bacterial count (TBC) and total fungal count (TFC) in the air between A/B and C/D supermarkets (p = 0.0042 and p = 0.0002, respectively). Regarding surfaces, a statistically significant difference in TBC emerged between A/B and C/D supermarkets (p = 0.0101). To the best of our knowledge, this is the first study evaluating the effect of ozone on commercial structures in Italy. Future investigations, supported by a multidisciplinary approach, will make it possible to deepen the knowledge on this method of sanitation, in light of any other epidemic/pandemic waves.
New Insights in Acanthamoeba
Authors: Reyes-Batlle María , Sifaoui Ines , Rodríguez-Expósito Rubén L. , Piñero José E. , Lorenzo-Morales Jacob
Published: May 2022

Acanthamoeba is a free-living amoeba genus able to cause severe infections, such as Granulomatous amoebic encephalitis (GAE), epithelial disorders and a sight-threatening disease called Acanthamoeba keratitis (AK) [...]
Visceral Leishmaniasis and the Skin: Dermal Parasite Transmission to Sand Flies
Authors: Arumugam Sahaana , Scorza Breanna M. , Petersen Christine
Published: May 2022

Visceral leishmaniasis is a parasitic disease with significant dermal tropism. The skin is an important site of infection contributing to parasite transmission to naïve sand flies, but understanding how parasitism of host skin and the related immune microenvironment supports or prevents skin parasite replication is now the focus of major investigation in the field of leishmaniasis research. Here, we review dermatoimmunology during visceral leishmaniasis (VL), dermal Leishmania parasite burden, and the role of skin parasitism in transmissibility to sand fly vectors. First, we discuss the epidemiology of VL amongst dogs, the primary zoonotic reservoir for human infection. We explore the association between spatial distribution and the burden of parasites in the skin in driving outward transmission. Factors associated with parasite persistence in the skin are examined. We discuss systemic immunity during VL and what is known about immunological correlates in the skin microenvironment. Finally, we touch on factors egested into the skin during Leishmania inoculation by sand flies. Throughout, we discuss factors associated with the early and chronic establishment of Leishmania parasites in the skin and the role of the dermal immune response.
Microencapsulating Alginate-Based Polymers for Probiotics Delivery Systems and Their Application
Authors: Wang Xiaochen , Gao Shukun , Yun Shuaiting , Zhang Mingjing , Peng Liyang , Li Yingxiu , Zhou Yanxia
Published: May 2022

Probiotics exhibit many health benefits and a great potential for broad applications in pharmaceutical fields, such as prevention and treatment of gastrointestinal tract diseases (irritable bowel syndrome), prevention and therapy of allergies, certain anticancer effects, and immunomodulation. However, their applications are limited by the low viability and metabolic activity of the probiotics during processing, storage, and delivery in the digestive tract. To overcome the mentioned limitations, probiotic delivery systems have attracted much attention. This review focuses on alginate as a preferred polymer and presents recent advances in alginate-based polymers for probiotic delivery systems. We highlight several alginate-based delivery systems containing various types of probiotics and the physical and chemical modifications with chitosan, cellulose, starch, protein, fish gel, and many other materials to enhance their performance, of which the viability and protective mechanisms are discussed. Withal, various challenges in alginate-based polymers for probiotics delivery systems are traced out, and future directions, specifically on the use of nanomaterials as well as prebiotics, are delineated to further facilitate subsequent researchers in selecting more favorable materials and technology for probiotic delivery.
Liver Injury with Nintedanib: A Pharmacovigilance–Pharmacokinetic Appraisal
Authors: Raschi Emanuel , Fusaroli Michele , Gatti Milo , Caraceni Paolo , Poluzzi Elisabetta , De Ponti Fabrizio
Published: May 2022

Drug-induced liver injury (DILI) with nintedanib has emerged as an adverse event of special interest in premarketing clinical trials. We characterized DILI with nintedanib in the real world and explored the underlying pharmacological basis. First, we assessed serious hepatic events reported to the Food and Drug Administration’s Adverse Event Reporting System by combining the disproportionality approach [reporting odds ratio (ROR) with 95% confidence interval (CI)] with individual case assessment. Demographic and clinical features were inspected (seriousness, onset, discontinuation, dechallenge/rechallenge, concomitant drugs) to implement an ad hoc causality assessment scoring system. Second, we appraised physiochemical and pharmacokinetic parameters possibly predictive of DILI occurrence. Significant disproportionality was found for nintedanib as compared to pirfenidone (N = 91; ROR = 4.77; 95% CI = 3.15–7.39). Asian population, low body weight (59 kg), and rapid DILI onset (13.5 days) emerged as clinical features. Hospitalization and discontinuation were found in a significant proportion of cases (32% and 36%, respectively). In 24% of the cases, at least two potentially hepatotoxic drugs (statins, proton pump inhibitors, antibiotics) were recorded. Causality was at least possible in 92.3% of the cases. High lipophilicity and predicted in silico inhibition of liver transporters emerged as potential pharmacokinetic features supporting the biological plausibility. Although causality cannot be demonstrated, clinicians should consider early monitoring and medication review on a case-by-case basis.
Reparative Efficacy of Liposome-Encapsulated Oleanolic Acid against Liver Inflammation Induced by Fine Ambient Particulate Matter and Alcohol in Mice
Authors: Wei Ching-Ting , Wang Yu-Wen , Wu Yu-Chiuan , Lin Li-Wei , Chen Chia-Chi , Chen Chun-Yin , Kuo Shyh-Ming
Published: May 2022

Airborne fine particulate matter (PM2.5) is a severe problem and is associated with health issues including liver diseases. Workers performing manual labor tend to be alcohol consumers during work, where they are also exposed to PM2.5. Long-term PM2.5 exposure can increase oxidative stress, leading to inflammation. Whether long-term exposure to air pollution and alcohol synergistically increases liver fibrosis risk warrants investigation. Oleanolic acid (OA)—a triterpenoid—has antioxidant and anti-inflammatory activities, but its low water solubility and cytotoxicity impair its potential applications. In this study, we fabricated liposomal OA nanoparticles (Lipo-OAs); then, we evaluated the anti-inflammatory effect on exposed cells and the ameliorative effect of Lipo-OAs on PM2.5 and alcohol-induced liver fibrosis in mice. The half maximal inhibitory concentration of PM2.5 for hepatic stellate cells was 900 μg/mL; at a concentration of ≥600 μg/mL, PM2.5 significantly increased interleukin-6 and tumor necrosis factor-α production. OA encapsulation in Lipo-OAs, 353 ± 140 nm in diameter with 79% encapsulation efficiency, significantly reduced OA cytotoxicity. Lipo-OAs treatment significantly reduced alanine aminotransferase, aspartate aminotransferase, and γ-glutamyltransferase levels; histologically, it alleviated steatosis and improved Ishak’s modified HAI score. In conclusion, Lipo-OAs have potential anti-inflammatory and reparative effects for PM2.5 and alcohol-induced liver injury treatment.
Photooxidation of 2,2′-(Ethyne-1,2-diyl)dianilines: An Enhanced Photocatalytic Properties of New Salophen-Based Zn(II) Complexes
Authors: Subburu Mahesh , Gade Ramesh , Chetti Prabhakar , Pola Someshwar
Published: May 2022

Under solvothermal conditions, the Zn(II) complexes formed from salophen-based ligands with N and O donor atoms are reported. These Zn(II) complexes were initially confirmed through elemental analysis and supported by mass spectral data. The purity of the ligands and Zn(II) complexes was confirmed by using NMR spectral studies. The functional group complexation was established by FT-IR analysis. Additional supportive information about the complexes is also reported through molar conductance and thermal studies. The bandgap energies of the ligands and Zn(II) complexes are estimated with UV-visible DRS studies. The rate of recombination of hole–electron pairs is directly related to photocatalytic activity, which is confirmed by using emission spectral analysis. The surface metaphors for ligands and complexes are obtained from FESEM analysis. These new sequences of Zn(II) complexes were used for the photooxidation of 2,2′-(ethyne-1,2-diyl)dianiline and its derivatives. Mechanistic studies on the fast degradation of dyes were supported in the presence of several scavengers. The rapid photooxidation process in the presence of [Zn(CPAMN)] has been demonstrated, and a highly efficient photocatalyst for the photooxidation of 2,2′-(ethyne-1,2-diyl) dianiline has been proposed. Furthermore, the experimental findings are supported by the DFT studies.
ZmLBD5 Increases Drought Sensitivity by Suppressing ROS Accumulation in Arabidopsis
Authors: Xiong Jing , Zhang Weixiao , Zheng Dan , Xiong Hao , Feng Xuanjun , Zhang Xuemei , Wang Qingjun , Wu Fengkai , Xu Jie , Lu Yanli
Published: May 2022

Drought stress is known to significantly limit crop growth and productivity. Lateral organ boundary domain (LBD) transcription factors—particularly class-I members—play essential roles in plant development and biotic stress. However, little information is available on class-II LBD genes related to abiotic stress in maize. Here, we cloned a maize class-II LBD transcription factor, ZmLBD5, and identified its function in drought stress. Transient expression, transactivation, and dimerization assays demonstrated that ZmLBD5 was localized in the nucleus, without transactivation, and could form a homodimer or heterodimer. Promoter analysis demonstrated that multiple drought-stress-related and ABA response cis-acting elements are present in the promoter region of ZmLBD5. Overexpression of ZmLBD5 in Arabidopsis promotes plant growth under normal conditions, and suppresses drought tolerance under drought conditions. Furthermore, the overexpression of ZmLBD5 increased the water loss rate, stomatal number, and stomatal apertures. DAB and NBT staining demonstrated that the reactive oxygen species (ROS) decreased in ZmLBD5-overexpressed Arabidopsis. A physiological index assay also revealed that SOD and POD activities in ZmLBD5-overexpressed Arabidopsis were higher than those in wild-type Arabidopsis. These results revealed the role of ZmLBD5 in drought stress by regulating ROS levels.
Ethnopharmacological Study of Medicinal Plants Used for the Treatment of Cardiovascular Diseases and Their Associated Risk Factors in sub-Saharan Africa
Authors: Odukoya Johnson Oluwaseun , Odukoya Julianah Olayemi , Mmutlane Edwin Mpho , Ndinteh Derek Tantoh
Published: May 2022

Cardiovascular diseases (CVDs) are the leading cause of global mortality, including deaths arising from non-communicable diseases in sub-Saharan Africa (SSA). Consequently, this study aimed to provide details of medicinal plants (MPs) employed in SSA for the treatment of CVDs and their related risk factors to open new avenues for the discovery of novel drugs. The extensive ethnopharmacological literature survey of these MPs in 41 SSA countries was based on studies from 1982 to 2021. It revealed 1,085 MPs belonging to 218 botanical families, with Fabaceae (9.61%), Asteraceae (6.77%), Apocynaceae (3.93%), Lamiaceae (3.75%), and Rubiaceae (3.66%) being the most represented. Meanwhile, Allium sativum L., Persea americana Mill., Moringa oleifera Lam., Mangifera indica L., and Allium cepa L. are the five most utilised plant species. The preferred plant parts include the leaves (36%), roots (21%), barks (14%), fruits (7%), and seeds (5%), which are mostly prepared by decoction. Benin, Mauritius, Nigeria, South Africa, and Togo had the highest reported use while most of the investigations were on diabetes and hypertension. Despite the nutraceutical advantages of some of these MPs, their general toxicity potential calls for caution in their human long-term use. Overall, the study established the need for governments of SSA countries to validate the efficacy/safety of these MPs as well as provide affordable, accessible, and improved modern healthcare services.
Isolation and Characterization of Werneria Chromene and Dihydroxyacidissimol from Burkillanthus malaccensis (Ridl.) Swingle
Authors: Zulkipli Masyitah , Mahbub Nuzum , Fatima Ayesha , Wan-Lin Stefanie Lim , Khoo Teng-Jin , Mahboob Tooba , Rajagopal Mogana , Samudi Chandramathi , Kathirvalu Gheetanjali , Abdullah Nor Hayati , Pinho Ana Rita , Oliveira Sonia M. R. , Pereira Maria de Lourdes , Rahmatullah Mohammed , Hasan Anamul , Paul Alok K. , Butler Mark S. , Nawaz Muhammad , Wilairatana Polrat , Nissapatorn Veeranoot , Wiart Christophe
Published: May 2022

The secondary metabolites of endemic plants from the Rutaceae family, such as Burkillanthusmalaccensis (Ridl.) Swingle from the rainforest of Malaysia, has not been studied. Burkillanthusmalaccensis (Ridl.) Swingle may produce antibacterial and antibiotic-potentiating secondary metabolites. Hexane, chloroform, and methanol extracts of leaves, bark, wood, pericarps, and endocarps were tested against bacteria by broth microdilution assay and their antibiotic-potentiating activities. Chromatographic separations of hexane extracts of seeds were conducted to investigate effective phytochemicals and their antibacterial activities. Molecular docking studies of werneria chromene and dihydroxyacidissiminol against SARS-CoV-2 virus infection were conducted using AutoDock Vina. The methanol extract of bark inhibited the growth of Staphylococcusaureus, Escherichiacoli, and Pseudomonasaeruginosa with the minimum inhibitory concentration of 250, 500, and 250 µg/mL, respectively. The chloroform extract of endocarps potentiated the activity of imipenem against imipenem-resistant Acinetobacterbaumannii. The hexane extract of seeds increased the sensitivity of P. aeruginosa against ciprofloxacin and levofloxacin. The hexane extract of seeds and chloroform extract of endocarps were chromatographed, yielding werneria chromene and dihydroxyacidissiminol. Werneria chromene was bacteriostatic for P.aeruginosa and P.putida, with MIC/MBC values of 1000 > 1000 µg/mL. Dihydroxyacidissiminol showed the predicted binding energies of −8.1, −7.6, −7.0, and −7.5 kcal/mol with cathepsin L, nsp13 helicase, SARS-CoV-2 main protease, and SARS-CoV-2 spike protein receptor-binding domain S-RBD. Burkillanthusmalaccensis (Ridl.) Swingle can be a potential source of natural products with antibiotic-potentiating activity and that are anti-SARS-CoV-2.
A Critical Review of Additive Manufacturing Techniques and Associated Biomaterials Used in Bone Tissue Engineering
Authors: Wu Yanli , Lu Yongtao , Zhao Ming , Bosiakov Sergei , Li Lei
Published: May 2022

With the ability to fabricate complex structures while meeting individual needs, additive manufacturing (AM) offers unprecedented opportunities for bone tissue engineering in the biomedical field. However, traditional metal implants have many adverse effects due to their poor integration with host tissues, and therefore new material implants with porous structures are gradually being developed that are suitable for clinical medical applications. From the perspectives of additive manufacturing technology and materials, this article discusses a suitable manufacturing process for ideal materials for biological bone tissue engineering. It begins with a review of the methods and applicable materials in existing additive manufacturing technologies and their applications in biomedicine, introducing the advantages and disadvantages of various AM technologies. The properties of materials including metals and polymers, commonly used AM technologies, recent developments, and their applications in bone tissue engineering are discussed in detail and summarized. In addition, the main challenges for different metallic and polymer materials, such as biodegradability, anisotropy, growth factors to promote the osteogenic capacity, and enhancement of mechanical properties are also introduced. Finally, the development prospects for AM technologies and biomaterials in bone tissue engineering are considered.
Spontaneous DNA Synapsis by Forming Noncanonical Intermolecular Structures
Authors: Severov Viacheslav , Tsvetkov Vladimir , Barinov Nikolay , Babenko Vladislav , Klinov Dmitry , Pozmogova Galina
Published: May 2022

We report the spontaneous formation of DNA-DNA junctions in solution in the absence of proteins visualised using atomic force microscopy. The synapsis position fits with potential G-quadruplex (G4) sites. In contrast to the Holliday structure, these conjugates have an affinity for G4 antibodies. Molecular modelling was used to elucidate the possible G4/IM-synaptic complex structures. Our results indicate a new role of the intermolecular noncanonical structures in chromatin architecture and genomic rearrangement.
A Comprehensive Review of Biopolymer Fabrication in Additive Manufacturing Processing for 3D-Tissue-Engineering Scaffolds
Authors: Arifin Nurulhuda , Sudin Izman , Ngadiman Nor Hasrul Akhmal , Ishak Mohamad Shaiful Ashrul
Published: May 2022

The selection of a scaffold-fabrication method becomes challenging due to the variety in manufacturing methods, biomaterials and technical requirements. The design and development of tissue engineering scaffolds depend upon the porosity, which provides interconnected pores, suitable mechanical strength, and the internal scaffold architecture. The technology of the additive manufacturing (AM) method via photo-polymerization 3D printing is reported to have the capability to fabricate high resolution and finely controlled dimensions of a scaffold. This technology is also easy to operate, low cost and enables fast printing, compared to traditional methods and other additive manufacturing techniques. This article aims to review the potential of the photo-polymerization 3D-printing technique in the fabrication of tissue engineering scaffolds. This review paper also highlights the comprehensive comparative study between photo-polymerization 3D printing with other scaffold fabrication techniques. Various parameter settings that influence mechanical properties, biocompatibility and porosity behavior are also discussed in detail.
Physical Properties of Slide-Ring Material Reinforced Ethylene Propylene Diene Rubber Composites
Authors: Kim Gyuri , Sahu Pranabesh , Oh Jeong Seok
Published: May 2022

High-damping rubber composites were prepared by mixing ethylene propylene diene monomer rubber (EPDM) with slide-ring (SR) materials using a two-roll mill, followed by a compression molding technique. SR material has a novel supramolecular structure with unique softness and slidable crosslink junctions. The mechanical strength, thermal stability, compression set property, and damping performance of the composites were investigated. The use of the high damping SR phase dispersed in the EPDM matrix displayed improved physical properties and damping performance compared to those of virgin rubber. As SR content increases in the composites, the damping factor of SR/EPDM blends becomes higher at room temperature. In addition to this, the SR composites showed excellent improvements in the compression set properties. The composites showed a compression set improvement of 35–38% compared to virgin EPDM. These improvements are due to the “pulley effect” of slide-ring materials. Therefore, these materials present a robust platform for making novel elastomer composites for high-performance damping and sealing applications.
Effect of Preparation Conditions on Application Properties of Environment Friendly Polymer Soil Consolidation Agent
Authors: Wang Shaoli , Song Shengju , Yang Xuping , Xiong Zhengqi , Luo Chaoxing , Xia Yongxiu , Wei Donglu , Wang Shaobo , Liu Lili , Wang Hong , Sun Lifang , Du Lichao , Li Shaofeng
Published: May 2022

In order to improve the survival rate of transplanted seedlings and improve the efficiency of seedling transplantation, we developed an environmental friendly polymer konjac glucomannan (KGM)/chitosan (CA)/polyvinyl alcohol (PVA) ternary blend soil consolidation agent to consolidate the soil ball at the root of transplanted seedlings. In the previous research, we found that although the prepared KGM/CA/PVA ternary blend soil consolidation agent can consolidate the soil ball at the root of the seedling, the medium solid content of the adhesive was high, which affects its spraying at the root of the seedling. At the same time, the preparation temperature of the KGM/CA/PVA ternary blend was also high. Therefore, to reduce the energy consumption and the cost of the KGM/CA/PVA ternary blend soil consolidation agent in the preparation process, this paper studied the influence of preparation conditions on the application performance of the environmental friendly polymer soil consolidation agent. We aimed to reduce the highest value CA content and preparation temperature of the KGM/CA/PVA ternary blend adhesive on the premise of ensuring the consolidation performance of the KGM/CA/PVA ternary blend adhesive on soil balls. It was prepared for the popularization and application of the environmental friendly polymer KGM/CA/PVA ternary blend soil consolidation agent in seedling transplanting. Through this study, it was found that the film-forming performance of the adhesive was better when the KGM content was 4.5%, the CA content was in the range of 2–3%, the PVA content was in the range of 3–4%, and the preparation temperature was higher than 50 °C. The polymer soil consolidation agent prepared under this condition has a good application prospect in seedling transplanting.
Bone Mineralization in Electrospun-Based Bone Tissue Engineering
Authors: Lim Dong-Jin
Published: May 2022

Increasing the demand for bone substitutes in the management of bone fractures, including osteoporotic fractures, makes bone tissue engineering (BTE) an ideal strategy for solving the constant shortage of bone grafts. Electrospun-based scaffolds have gained popularity in BTE because of their unique features, such as high porosity, a large surface-area-to-volume ratio, and their structural similarity to the native bone extracellular matrix (ECM). To imitate native bone mineralization through which bone minerals are deposited onto the bone matrix, a simple but robust post-treatment using a simulated body fluid (SBF) has been employed, thereby improving the osteogenic potential of these synthetic bone grafts. This study highlights recent electrospinning technologies that are helpful in creating more bone-like scaffolds, and addresses the progress of SBF development. Biomineralized electrospun bone scaffolds are also reviewed, based on the importance of bone mineralization in bone regeneration. This review summarizes the potential of SBF treatments for conferring the biphasic features of native bone ECM architectures onto electrospun-based bone scaffolds.
Ammonio Methacrylate Copolymer (Type B)-Diltiazem Interactions in Solid Dispersions and Microsponge Drug-Delivery Systems
Authors: Kolev Iliyan , Ivanova Nadezhda , Topouzova-Hristova Tanya , Dimova Tanya , Koseva Pavlina , Vasileva Ivalina , Ivanova Sonya , Apostolov Anton , Alexieva Gergana , Tzonev Atanas , Strashilov Vesselin
Published: May 2022

This paper presents a complex analytical study on the distribution, solubility, amorphization, and compatibility of diltiazem within the composition of Eudragit RS 100-based particles of microspongeous type. For this purpose, a methodology combining attenuated total reflectance Fourier transform infrared (ATR-FTIR) absorption spectroscopy, differential scanning calorimetry (DSC), scanning electron microscopy with energy-dispersive X-ray microanalysis (SEM-EDX), and in vitro dissolution study is proposed. The correct interpretation of the FTIR and drug-dissolution results was guaranteed by the implementation of two contrasting reference models: physical drug–polymer mixtures and casting-obtained, molecularly dispersed drug–polymer composites (solid dispersions). The spectral behavior of the drug–polymer composites in the carbonyl frequency (νCO) region was used as a quality marker for the degree of their interaction/mutual solubility. A spectral-pattern similarity between the microsponge particles and the solid dispersions indicated the molecular-type dispersion of the former. The comparative drug-desorption study and the qualitative observations over the DSC and SEM-EDX results confirmed the successful synthesis of a homogeneous coamorphous microsponge-type formulation with excellent drug-loading capacity and “controlled” dissolution profile. Among them, the drug-delivery particles with 25% diltiazem content (M-25) were recognized as the most promising, with the highest population of drug molecules in the polymer bulk and the most suitable desorption profile. Furthermore, an economical and effective analytical algorithm was developed for the comprehensive physicochemical characterization of complex delivery systems of this kind.
‘Genderism vs. Humanism’: The Generational Shift and Push for Implementing Gender Equality within Soka Gakkai-Japan
Authors: Fisker-Nielsen Anne Mette
Published: May 2022

This paper investigates how young Japanese women in contemporary Soka Gakkai (SG) navigate Japan’s continuous gender stratified society that remains culturally rooted in the ‘salaryman-housewife’ ideology. How are young SG members reproducing or contesting these hegemonic gender norms that few seek to emulate? While SG has long proclaimed that it stands for gender equality, its employment structure and organization in Japan until recently reflected the typical male breadwinner ideology that came to underpin the post-war Japanese nation-state and systemic gender division of labor. As shown here, this did not mean that SG women were without power; in fact, in many ways they drove organizational developments in the Japanese context. The recent imposition of the global framework for Sustainable Development Goals of 2015 has enabled SG to more substantially challenge its own patriarchal public front. Based on long-term fieldwork, in-depth interviews and multiple group discussions with SG members in their 20s, this article explores how SG-Japan is being challenged to follow its own discourse of ‘globalism’ and ‘Buddhist humanism’, promoted by Daisaku Ikeda since the 1990s. Using Bourdieu’s analysis of symbolic power, the research shows how Japan’s powerful doxa of ‘genderism’ that held sway over earlier generations is currently being challenged by a glocalized Buddhist discourse that identifies Nichiren Buddhism as ‘humanism’ rather than Japanese ‘genderism’.
What Does Joy in Living Mean to Elderly Residents of Nursing Homes in Singapore?
Authors: Dayanandan Swapna , Mehta Kalyani
Published: May 2022

The rapid ageing of Singapore’s population has led to the phenomenon of more elderly spending more total years in nursing homes. This study aimed to explore the meaning of Joy in Living to elderly residents of nursing homes in Singapore, the enabling and disenabling conditions to Joy in Living in nursing homes and how Person-centered Care can support Joy in Living in nursing homes. The concept of Joy in Living is used in this study as it is unique to an individual elderly’s experience; The study employed hermeneutical phenomenological research methodology to allow for the exploration of Joy in Living in lived experiences of elderly residents through in-depth sixteen semi-structured interviews with elderly residents and six participant observations of three nursing homes (pre and post interviews) between July 2021 and November 2021; Seven themes for Joy in Living experiences to flourish were identified, including “supportive nursing home environment and practices”, “connectedness through meaningful relationships”, “meaningful daily living”, “fulfil the need for spiritual care”, “personal control”, “desire to be free from worries”, and “adapting to changes”, each of which explains a facet of Joy in Living experiences of the elderly residing in nursing homes. These themes include the enabling and disenabling conditions to Joy in Living in nursing homes; Focusing efforts and resources on enabling the seven themes, including fulfilling the need for spiritual care will allow Joy in Living experiences of elderly to flourish in nursing homes. This in turn promotes better psychosocial well-being of the elderly and better living environments where nursing home residents may enjoy satisfactory accommodation while spending their remaining years in joy.
Beyond Literal Idolatry: Translating Theo-Logos from Judgment to Love
Authors: Boscaljon Daniel
Published: May 2022

This article explores the capacity for narrating the name of God as a way to liberate the suffering of the world. The first section of this article offers a brief overview of Walter Benjamin’s linguistic theory as it relates to the issue of literal idolatry. In the second section, the content of exploring Ricoeur’s movement toward a poetic faith creates a formal anomaly in which his “byway” is something that may be crucial for readers or may be unnecessary: it speaks to the discontinuity and rupture enabled by incorporating silence into speech. The third section flows from the first and third, discussing the difficulty and importance of naming God as an embodied speech act. This looks at the particular situation of parables, including perspectives from Thomas Altizer and J. Hillis Miller. The fourth section focuses on the psychodynamic work of Jessica Benjamin as it models a way of bringing an embodied witness to the world in a performance of divine love.
Runoff Estimation in the Upper Reaches of the Heihe River Using an LSTM Model with Remote Sensing Data
Authors: Xue Huazhu , Liu Jie , Dong Guotao , Zhang Chenchen , Jia Dao
Published: May 2022

Runoff estimations play an important role in water resource planning and management. Many accomplishments have been made in runoff estimations based on data recorded at meteorological stations; however, the advantages of the use of remotely sensed data in estimating runoff in watersheds for which data are lacking remain to be investigated. In this study, the MOD13A2 normalized difference vegetation index (NDVI), TRMM3B43 precipitation (P), MOD11A2 land–surface temperature (LST), MOD16A2 evapotranspiration (ET) and hydrological station data were used as data sources with which to estimate the monthly runoff through the application of a fully connected long short–term memory (LSTM) model in the upstream reach of the Heihe River basin in China from 2001 to 2016. The results showed that inputting multiple remote sensing parameters improved the quality of runoff estimation compared to the use of rain gauge observations; an increase in R2 from 0.91 to 0.94 was observed from the implementation of this process, and Nash–Sutcliffe efficiency (NSE) showed an improvement from 0.89 to 0.93. The incorporation of rain gauge data as well as satellite data provided a slight improvement in estimating runoff with a respective R2 value of 0.95 and NSE value of 0.94. This indicates that the LSTM model based on remote sensing data has great potential for runoff estimation, and data obtained by remote sensing technology provide an alternative approach for estimating runoff in areas for which available data are lacking.
UAV-Based Multitemporal Remote Sensing Surveys of Volcano Unstable Flanks: A Case Study from Stromboli
Authors: Gracchi Teresa , Tacconi Stefanelli Carlo , Rossi Guglielmo , Di Traglia Federico , Nolesini Teresa , Tanteri Luca , Casagli Nicola
Published: May 2022

UAV-based photogrammetry is becoming increasingly popular even in application fields that, until recently, were deemed unsuitable for this technique. Depending on the characteristics of the investigated scenario, the generation of three-dimensional (3D) topographic models may in fact be affected by significant inaccuracies unless site-specific adaptations are implemented into the data collection and processing routines. In this paper, an ad hoc procedure to exploit high-resolution aerial photogrammetry for the multitemporal analysis of the unstable Sciara del Fuoco (SdF) slope at Stromboli Island (Italy) is presented. Use of the technique is inherently problematic because of the homogeneous aspect of the gray ash slope, which prevents a straightforward identification of match points in continuous frames. Moreover, due to site accessibility restrictions enforced by local authorities after the volcanic paroxysm in July 2019, Ground Control Points (GCPs) cannot be positioned to constrain georeferencing. Therefore, all 3D point clouds were georeferenced using GCPs acquired in a 2019 (pre-paroxysm) survey, together with stable Virtual Ground Control Points (VGCPs) belonging to a LiDAR survey carried out in 2012. Alignment refinement was then performed by means of an iterative algorithm based on the closest points. The procedure succeeded in correctly georeferencing six high-resolution point clouds acquired from April 2017 to July 2021, whose time-focused analysis made it possible to track several geomorphological structures associated with the continued volcanic activity. The procedure can be further extended to smaller-scale analyses such as the estimation of locally eroded/accumulated volumes and pave the way for rapid UAV-based georeferenced surveys in emergency conditions at the SdF.
Incorporating a Hyperspectral Direct-Diffuse Pyranometer in an Above-Water Reflectance Algorithm
Authors: Jordan Thomas M. , Simis Stefan G. H. , Grötsch Philipp M. M. , Wood John
Published: May 2022

In situ hyperspectral remote-sensing reflectance (Rrs(λ)) is used to derive water quality products and perform autonomous monitoring of aquatic ecosystems. Conventionally, above-water Rrs(λ) is estimated from three spectroradiometers which measure downwelling planar irradiance (Ed(λ)), sky radiance (Ls(λ)), and total upwelling radiance (Lt(λ)), with a scaling of Ls(λ)/Ed(λ) used to correct for surface-reflected radiance. Here, we incorporate direct and diffuse irradiance, (Edd(λ)) and Eds(λ)), from a hyperspectral pyranometer (HSP) in an Rrs(λ) processing algorithm from a solar-tracking radiometry platform (So-Rad). HSP measurements of sun and sky glint (scaled Edd(λ)/Ed(λ) and Eds(λ)/Ed(λ)) replace model-optimized terms in the 3C (three-glint component) Rrs(λ) algorithm, which estimates Rrs(λ) via spectral optimization of modelled atmospheric and water properties with respect to measured radiometric quantities. We refer to the HSP-enabled method as DD (direct-diffuse) and compare differences in Rrs(λ) and Rrs(λ) variability (assessed over 20 min measurement cycles) between 3C and DD as a function of atmospheric optical state using data from three ports in the Western Channel. The greatest divergence between the algorithms occurs in the blue part of the spectrum where DD has significantly lower Rrs(λ) variability than 3C in clearer sky conditions. We also consider Rrs(λ) processing from a hypothetical two-sensor configuration (using only the Lt(λ) spectroradiometer and the HSP and referred to as DD2) as a potential lower-cost measurement solution, which is shown to have comparable Rrs(λ) and Rrs(λ) variability to DD in clearer sky conditions. Our results support that the HSP sensor can fulfil a dual role in aquatic ecosystem monitoring by improving precision in Rrs(λ) alongside its primary function to characterize aerosols.
Design and Verification of a Double-Grating Spectrometer System (DGSS) for Simultaneous Observation of Aerosols, Water Vapor and Clouds
Authors: Li Jifeng , Lin Guanyu , Wu Heng , Duan Minzheng , Cao Diansheng , Wang Longqi
Published: May 2022

Simultaneous observation of aerosols, water vapor, and clouds is conducive to the analysis of their interactions, and the consistency of observation equipment, instrument performance, and observation time is crucial. Molecular oxygen A-band (758–778 nm) and water vapor absorption band (758–880 nm) are two bands with similar wavelengths, and the hyperspectral remote sensing information of these two bands can be exploited to invert the vertical profile of aerosol and water vapor. In this paper, a double-grating spectrometer system (DGSS) was developed. DGSS uses a telescope system and fiber to introduce multi-angle, double-band sunlight, and it splits light synchronously (non-sequentially) to different positions of the detector through a slit plate and two gratings. The DGSS was calibrated in the laboratory and observed in the external field. The results indicated that the spectral resolution reached 0.06 nm (molecular oxygen A-band, 758–778 nm) and 0.24 nm (water vapor absorption band, 758–880 nm). Meanwhile, the spectra of the two bands (three angles in each band) are not aliased on the detector. Besides, the multi-angle simultaneous observation of the high-resolution spectra of the two bands is realized, which proves the effectiveness of this method. This study will provide a scientific basis for the observation of aerosol, water vapor, and cloud ground-based networks.
A Morphological Feature-Oriented Algorithm for Extracting Impervious Surface Areas Obscured by Vegetation in Collaboration with OSM Road Networks in Urban Areas
Authors: Mao Taomin , Fan Yewen , Zhi Shuang , Tang Jinshan
Published: May 2022

Remote sensing is the primary way to extract the impervious surface areas (ISAs). However, the obstruction of vegetation is a long-standing challenge that prevents the accurate extraction of urban ISAs. Currently, there are no general and systematic methods to solve the problem. In this paper, we present a morphological feature-oriented algorithm, which can make use of the OSM road network information to remove the obscuring effects when the ISAs are extracted. Very high resolution (VHR) images of Wuhan, China, were used in experiments to verify the effectiveness of the proposed algorithm. Experimental results show that the proposed algorithm can improve the accuracy and completeness of ISA extraction by our previous deep learning-based algorithm. In the proposed algorithm, the overall accuracy (OA) is 86.64%. The results show that the proposed algorithm is feasible and can extract the vegetation-obscured ISAs effectively and precisely.
Green Area Index and Soil Moisture Retrieval in Maize Fields Using Multi-Polarized C- and L-Band SAR Data and the Water Cloud Model
Authors: Bouchat Jean , Tronquo Emma , Orban Anne , Neyt Xavier , Verhoest Niko E. C. , Defourny Pierre
Published: May 2022

The green area index (GAI) and the soil moisture under the canopy are two key variables for agricultural monitoring. The current most accurate GAI estimation methods exploit optical data and are rendered ineffective in the case of frequent cloud cover. Synthetic aperture radar (SAR) measurements could allow the remote estimation of both variables at the parcel level, on a large scale and regardless of clouds. In this study, several methods were implemented and tested for the simultaneous estimation of both variables using the water cloud model (WCM) and dual-polarized radar backscatter measurements. The methods were tested on the BELSAR-Campaign data set consisting of in-situ measurements of bio-geophysical variables of vegetation and soil in maize fields combined with multi-polarized C- and L-band SAR data from Sentinel-1 and BELSAR. Accurate GAI estimates were obtained using a random forest regressor for the inversion of a pair of WCMs calibrated using cross and vertical co-polarized SAR data in L- and C-band, with correlation coefficients of 0.79 and 0.65 and RMSEs of 0.77 m2 m−2 and 0.98 m2 m−2, respectively, between estimates and in-situ measurements. The WCM, however, proved inadequate for soil moisture monitoring in the conditions of the campaign. These promising results indicate that GAI retrieval in maize crops using only dual-polarized radar data could successfully substitute for estimates derived from optical data.
Construction of an Ecological Security Pattern in an Urban–Lake Symbiosis Area: A Case Study of Hefei Metropolitan Area
Authors: Fan Xin , Rong Yuejing , Tian Chongxin , Ou Shengya , Li Jiangfeng , Shi Hong , Qin Yi , He Jiawen , Huang Chunbo
Published: May 2022

In the context of rapid urbanization, building an ecological security pattern that takes into account both ecological protection and economic growth is of great significance for guiding high-quality regional development. Taking the Hefei metropolitan area as an example, we identified the ecological source from three aspects—the importance of ecosystem services, ecological sensitivity, and landscape connectivity—by using NPP-VIIRS night light data, impervious surfaces, and the topographical index to the rest of the landscape resistance surface, and the least cumulative resistance model to identify ecological corridors and ecological buffer zones. We then constructed a comprehensive regional ecological security pattern. The results show the following: (1) The ecological source area of the Hefei metropolitan area is 15,538.74 km2, accounting for 24.5% of the total study area. It is mainly composed of the Dabie Mountains, the Yangtze River, the Huai River, and Chaohu Lake. (2) The area of an ecological buffer zone, ecological transition zone, and development and construction zone account for 21.8%, 39.7%, and 38.5%, respectively. Among them, the ecological buffer zone serves as a protective barrier for the ecological source area; therefore, development and construction activities should be restricted. The ecological transition zone should be constructed with low development intensity, and the development and construction zone can be carried out with greater development intensity. (3) The total length of the ecological corridor is 2816.89 km, with the mainland of the corridor being cultivated land. Identified by superposition of the land use, the area of conflict of urban expansion is 305.23 km2, mainly distributed along the Yangtze River and around Chao Lake. The results may provide decision support for the construction of ecological security in the study area.
Soil Salinity Variations and Associated Implications for Agriculture and Land Resources Development Using Remote Sensing Datasets in Central Asia
Authors: Measho Simon , Li Fadong , Pellikka Petri , Tian Chao , Hirwa Hubert , Xu Ning , Qiao Yunfeng , Khasanov Sayidjakhon , Kulmatov Rashid , Chen Gang
Published: May 2022

Global agricultural lands are becoming saline because of human activities that have affected crop production and food security worldwide. In this study, the spatiotemporal variability of soil electrical conductivity (EC) in Central Asia was evaluated based on high-resolution multi-year predicted soil EC data, Moderate Resolution Imaging Spectroradiometer (MODIS) land cover product, precipitation, reference evapotranspiration, population count, and soil moisture datasets. We primarily detected pixel-based soil EC trends over the past three decades and correlated soil EC with potential deriving factors. The results showed an overall increase in salt-affected areas between 1990 and 2018 for different land cover types. The soil EC trend increased by 6.86% (p < 0.05) over Central Asia during 1990–2018. The open shrub lands dominated by woody perennials experienced the highest increasing soil salinity trend, particularly in Uzbekistan and Turkmenistan local areas, while there was a decreasing soil EC trend in the cropland areas, such as in Bukhara and Khorezm (Uzbekistan). The main factors that affect the variability of soil salinity were strongly associated with population pressure and evapotranspiration. This study provides comprehensive soil EC variations and trends from the local to regional scales. Agriculture and land resource managers must tackle the rising land degradation concerns caused by the changing climate in arid lands and utilise geoinformatics.