bluuebunny/crossref_metadata_2025 huggingface dataset:
Development of Novel Indole-3-sulfonamide-heteroaryl Hybrids as Carbonic
Anhydrase Inhibitors: Design, Synthesis and in-vitro Screening
Authors: Chinchilli Krishna K. , Singh Priti , Swain Baijayantimala , Goud Nerella S. , Sigalapalli Dilep K. , Choli Abhishek , Angeli Andrea , Nanduri Srinivas , Yaddanapudi Venkata M. , Supuran Claudiu T. , Arifuddin Mohammed
Published: February 2023

Background:

Carbonic anhydrases (CAs, EC 4.2.1.1) catalyze the reversible hydration of carbon dioxide to
bicarbonate and a proton. Inhibition of isoforms IX and XII has induced potent anticancer effects.

Objective:

A series of indole-3-sulfonamide-heteroaryl hybrid (6a-y) was synthesized and screened for the inhibition of
human (h) hCA isoforms I, II, IX, and XII.

Methods:

The synthesis of target compounds (6a-y) was carried out in multistep starting from 5-nitro indole as starting
material by using classical reported reaction conditions. The steps involved are N-Alkylation Chlorosulfonation, amination,
reduction, and finally amidation reaction.

Results:

Amongst all the compounds (6a-y) synthesized and screened, 6l was found to be active against all the
screened hCA isoforms, with Ki ranging 8.03 μM, 4.15 μM, 7.09 μM, and 4.06 μM respectively. On the other hand, 6i,
6j, 6q, 6s, and 6t were highly selective against tumor-associated hCA IX, and 6u was selective against both hCA II and
hCA IX with moderate inhibitory activities under the range of 100 μM. These compounds showed good activity
against the tumor-associated hCA IX and might be developed as future drug leads for anticancer drug discovery.

Conclusion:

These compounds may be useful as starting points for the design and development of more selective and
potent hCA IX and XII inhibitors.
A Long-term Study of NeuroAid (MLC601, MLC901) in Patients with
Alzheimer's Disease; An Extension 8-year Follow-up Study
Authors: Pakdaman Hossein , Amini Harandi Ali , Gharagozli Koroush , Siavoshi Fatemeh , Shirzadeh Barough Siavash , Sharifipour Ehsan , Esfandani Akram , Ilkhani Saba , Tabatabaei Fatemeh Sadat , Sobhanian Seyed Ali
Published: February 2023

Background:

MLC601 and MLC901 showed neuroprotective and neuroregenerative
properties and positive results in the treatment of dementia and cognitive impairment. This study
aimed to investigate the long-term benefits of monotherapy with MLC601 and MLC901 in patients
with Alzheimer's disease (AD).

Methods:

In this study, patients with AD, diagnosed by DSM-IV criteria, were enrolled. Patients
have received MLC601 for four years, and their regimen has changed to MLC901 for another four
years. Recruited patients were followed to assess the efficacy and safety first of MLC601 and
MLC901. Mini-Mental State Examination (MMSE) and Alzheimer's Disease Assessment Scale-
Cognitive Subscale (ADAS-Cog) were used to assess cognitive function. Safety was evaluated by
monitoring adverse events (AEs) and abnormal findings in physical examinations or lab tests.

Results:

At the end of the trial, the changes in the mean (±SD) MMSE and ADAS-Cog scores were
5.1 (3.09) and 12.5 (10.89), respectively. Both scores showed a significant change in repeated
measure analysis, with the ADAS-Cog score indicating a higher change than the MMSE score (P <
0.001).

Conclusion:

For more than eight years, we studied monotherapy with NeuroAid (MLC601,
MLC901) in patients with AD. The study contributes further to the long-term safety and efficacy
data of MLC in patients with AD.
Pengembangan Job Sheet untuk Mata Kuliah Praktik Kerja Plambing dan Sanitasi pada Program studi Sarjana Jurusan Pendidikan Teknik Sipil dan Perencanaan Fakultas Teknik Universitas Negeri Yogyakarta
Authors: Primastuti Ayu Lhaksmi , Nayono Satoto Endar
Published: February 2023

Tujuan pada penelitian pengembangan ini adalah: 1) mengetahui bagaimana proses pengembangan job sheet pada mata kuliah Praktik Kerja Plambing dan Sanitasi untuk program studi Sarjana Pendidikan Teknik Sipil dan Perencanaan, Fakultas Teknik, Univesitas Negeri Yogyakarta, 2) mengetahui bagaimana hasil pengembangan job sheet pada mata kuliah Praktik Kerja Plambing dan Sanitasi untuk program studi Sarjana Pendidikan Teknik Sipil dan Perencanaan, Fakultas Teknik, Univesitas Negeri Yogyakarta. Model penelitian pengembangan yang digunakan menggunakan pengembangan 4-Dmodels yang dikemukakan oleh Thiagarajan dengan empat langkah utama yaitu: (1) define (pendefinisian), (2) design (perancangan), develop (pengembangan) dan (4) disseminate (penyebaran). Subjek yang disasar dalam penelitian pengembangan ini adalah mahasiswa yang sudah atau sedang melaksanakan mata kuliah praktik kerja plambing dan sanitasi. Instrumen penilaian ini menggunakan angket skala likert dengan 5 pilihan jawaban yang ditujukan kepada ahli materi, ahli media, dan pengguna atau dalam hal ini mahasiswa. Data yang diperoleh dari hasil penilaian yang dianalisis dengan teknik deskriptis kuantitatif dengan mencari harga reratanya. Berdasarkan data hasil pengembangan, dapat disimpulkan bahwa 1) proses pengembangan job sheet pada mata kuliah Praktik Kerja Plambing dan Sanitasi dilakukan menggunakan model pengembangan 4-D. 2) menurut penilaian oleh ahli materi, job sheet yang dikembangkan dikategorikan “layak” dengan nilai sebesar 82,6%, menurut ahli media dikategorikan “sangat layak” dengan nilai sebesar 94,7%, dan menurut pengguna (31 mahasiswa) dikategorikan “sangat layak” dengan nilai sebesar 90,89%. Job sheet yang dikembangkan didesiminasikan dengan cara mencetak media kemudian disebarkan dan digunakan sebagai pedoman melakukan praktik.
Accessibility to consumer credit by individual customers in financial companies: A case in the Mekong Delta
Authors:   Department of Business Administration, School of Economics, Can Tho University, Can Tho, Vietnam, Le Tan Nghiem , Le Long Hau ,   Department of Finance and Banking, School of Economics, Can Tho University, Can Tho, Vietnam, Duong Bich Tuyen ,   School of Economics, Nam Can Tho University, Can Tho, Vietnam, Tran Viet Thanh Truc ,   Department of Finance and Banking, School of Economics, Can Tho University, Can Tho, Vietnam, Nguyen Thi Thanh Tam ,   School of Economics, Nam Can Tho University, Can Tho, Vietnam
Published: February 2023

Consumer credit has grown rapidly in recent years with a variety of products from banks and financial companies. However, previous studies in Vietnam only approached factors affecting consumer lending decisions and credit access at commercial banks. The aim of this study is to determine the factors affecting the accessibility of consumer loans to individual customers at financial companies in the Mekong Delta. Data were collected by directly interviewing 200 people who applied for loans at financial companies (not banks). A pre-designed questionnaire and a random sampling method were used. According to the analysis results of the binary Logit regression model, male borrowers will have more difficulty in accessing consumer credit at financial companies. This result is in contrast to the results shown in some studies conducted at commercial banks. On the other hand, the positive impact on individuals' access to consumer loans of the variables of education level, income, and form of receiving income reinforces the results of previous studies on this topic. Besides, the higher the loan amount, the lower the probability of loan approval. From there, the author has proposed recommendations to improve access to consumer loans at financial companies and improve consumer credit products in the Mekong Delta.
Application of RIE-technology to control responsivity of 4H-SiC photodiodes
Authors: Afanasev A. V.  , Zabrodskiy  V. V.  , Ilyin V. A.  , Luchinin  V. V.  , Nikolaev A. V.  , Serkov A. V.  , Trushlyakova V. V.  , Chigirev D. A.
Published: February 2023

The possibility to increase the responsivity of 4H-SiC p+-n-n+-photodiodes by varying the thickness of the p+-epilayer has been studied. It is shown that the thinning of the upper epilayer by RIE with the use of metal contacts as a mask makes it possible to control both the maximum responsivity and the spectral dependence of the responsivity of photodiodes and does not lead to degradation of dark electrical characteristics. Keywords: 4H-SiC, p+-n-n+-photodiode, UV-range, p+-epilayer, reactive ion etching RIE, responsivity.
Study of active regions based on multiperiod GaAsN/InAs superlattice
Authors: Babichev A. V.  , Pirogov E.V.  , Sobolev M. S.  , Denisov D.V.  , Fominykh H.A.  , Baranov A. I.  , Gudovskikh A.S.  , Melnichenko I. A.  , Yunin P. A.  , Nevedomsky V. N.  , Tokarev M. V.  , Ber B.Ya.  , Gladyshev A. G.  , Karachinsky L. Ya.  , Novikov I. I.  , Egorov A. Yu.
Published: February 2023

The results of a study of nitrogen-containing active regions based on superlattices grown on GaAs substrates are presented. Active regions based on alternating InAs and GaAsN layers were fabricated by molecular-beam epitaxy using a nitrogen plasma source. Based on the XRD analysis, the thicknesses and average composition of superlattice layers are estimated. The study of dark-field images obtained by transmission electron microscopy showed the presence of interdiffusion of InAs into GaAsN. The results of a study of the photoluminescence and electroluminescence spectra at different pump levels are presented. Efficient electroluminescence is demonstrated near 1150 nm with a full width at half-maximum of about ~90 meV. Keywords: Superlattices, molecular beam epitaxy, gallium arsenide, dilute nitride, GaAsN, InAs.
Gallium vacancy --- shallows donor complexes in n-GaAs doped with elements of group VI Te or S (R e v i e w)
Authors: Gutkin A. A.  , AverkievN.S.
Published: February 2023

The results of studies of Ga vacancy --- shallow donor (Te or S atom substituting As atom in the lattice site closest to the vacancy VGa) complexes by methods of photoluminescence under resonant polarized excitation and piezospectroscopy are considered. An analysis of the experimental data in the classical dipole approximation shows that the symmetry of the complexes is lower than the trigonal one and their optical properties are explained in the model of a monoclinic defect with a symmetry plane of the \011\ type, in which the initial trigonal axis and the axis of the optical dipole lie. The reason for the lowering of the symmetry of the initially trigonal center is the distortions arising from the Jahn-Teller effect. A microscopic model is proposed that relates the behavior peculiarities of the optical properties of the VGaTeAs complex under uniaxial deformations and temperature changes with the structure of the electronic levels and the change in the charge state of the complex. The differences in this behavior observed for the VGaTeAs complex are analyzed and possible reasons for their appearance are discussed. Keywords: vacancy complexes in GaAs, Jahn-Teller effect, photoluminescence under resonant excitation, piezospectroscopy.
Templates for homoepitaxial growth of 3C-SiC obtained by direct bonding of silicon carbide wafers of differing polytype
Authors: Mynbaeva M. G.  , Amelchuk D. G.  , Smirnov A. N.  , Nikitina I. P.  , Lebedev S. P.  , Davydov V. Yu.  , Lebedev A. A.
Published: February 2023

An approach of direct bonding of SiC wafers of differing polytypes has been implemented in order to create a template for cubic 3C-SiC homoepitaxy. Heteroepitaxial 3C-SiC layers grown by chemical vapor deposition were transferred onto a hexagonal 6H-SiC wafer. The results of structural characterization showed that the quality of 3C-SiC sublimation epitaxy on the templates is comparable to the level of epitaxy of cubic silicon carbide by chemical vapor deposition method. It was confirmed that the 3C-SiC layer transferred onto the 6H-SiC substrate plays the role of a crystalline "seed" that determines cubic polytype of the overgrown SiC layer. Keywords: Silicon carbide, polytypes, direct bonding, templates, sublimation epitaxy.
Optical properties of Cu-=SUB=-2-=/SUB=-O nanowhiskers
Authors: Labzovskaya M. E.  , Novikov B. V.  , Serov A. Yu.  , Mikushev S. V.  , Davydov V. Yu.  , Smirnov A. N.  , Talalaev V. G.
Published: February 2023

The optical properties of Cu2O nanowhiskers grown by the liquid method with material deposition in an electric field have been studied. The spectral lines forbidden by the selection rules for perfect Cu2O crystals were found in the Raman spectra. The nature of related phonon states is analyzed. In the photoluminescence spectra in the red and near-IR regions, broad bands of defective origin are observed. It was found that the presence of a band at 650 nm (1.9 eV) is a specific feature of the photoluminescence of nanowhiskers. Its properties are studied and possible radiation mechanisms are discussed. In the intrinsic absorption region of nanowhiskers, the photoluminescence band at 572 nm (2.17 eV) associated with band-band transitions is detected. At a low excitation level, the emission of a free exciton n=1 of the yellow exciton series is observed with simultaneous emission of an optical phonon. Keywords: Cu2O, nanowhiskers, Raman, PL, exciton localization.
Picosecond pulses generation by fiber laser with semiconductor optical amplifier in 1.06 μm spectral range
Authors: Gadzhiev I. M.
Published: February 2023

Picosecond optical pulses generation in a ring fiber laser with a semiconductor optical amplifier was investigated. Optical spectrum width is minimal at a fundamental resonant repetition frequency of 45 MHz, corresponding to a fiber resonator length of 4.5 m. As the frequency increases, the spectral width increases by an order of magnitude while the pulse duration decreases to 18 ps, and the power increases to 0.5 W. The power of picosecond optical pulses at the output of the semiconductor amplifier is 7 times higher than in the CW mode due to the carrier accumulation effect that occurs with short pump pulses. Keywords: Semiconductor optical amplifier, Fiber ring laser, Gain-Switching.
Influence of fast dynamics effects on resonant ultrasonic vibrations of polycrystalline metal rods
Authors: Glazov A. L.  , Muratikov K. L.
Published: February 2023

A theoretical model for the formation of ultrasonic signals in metallic microcrystalline rods taking into account the metastable behavior of their defective states is proposed. The influence of metastable states of the defective structure of samples on the features of changes in their resonant frequencies in ultrasonic experiments of fast dynamics is analyzed. The decrease in Young's modulus in such processes is explained. The correspondence between theoretical and experimental data is demonstrated for the example of resonant acoustic vibrations of rods made of aluminum alloy D16. Keywords: nonlinear resonant ultrasonic spectroscopy, defect structure, mechanical stresses, effects of fast and slow dynamics.
Synthesis of potassium-sodium niobate powder in water vapor for piezoelectric ceramics manufacturing
Authors: Kholodkova A. A.  , Smirnov A. V.  , Tikhonov A. A.  , Shishkovsky
Published: February 2023

In this work, for the first time, single-phase potassium-sodium niobate powder with a primary particle size of 0.3-3.1 μm was synthesized in a water vapor medium at a temperature of 260oC and a pressure of 4.69 MPa. Two different techniques, the traditional one and laser stereolithography, were applied to produce powder-based ceramics with a density reaching 80-85% of the theoretical value. A set of the most important piezoelectric characteristics was studied for the prepared ceramics. The obtained preliminary results indicated the prospect of improving the phase, structural, and piezoelectric properties of potassium-sodium niobate ceramics by controlling the parameters of powder synthesis in water vapor and enhancement of the sintering conditions. Keywords: piezoelectric ceramics, complex oxide synthesis, potassium-sodium niobite, laser stereolithography.
Generation of high-power submillisecond metal ion beams
Authors: Ryabchikov A.I.  , Sivin D.O.
Published: February 2023

The possibility of using one grid electrode in the form of a part of a sphere for extraction from a free plasma boundary and focusing of metal ions is shown for the first time using titanium ions as an example to form a pulsed beam with a duration of 500 μs and a power density reaching 105 W/cm2. The results of studying the influence of the amplitude of the accelerating voltage in the range of 9-30 kV and the size of the grid cells on the efficiency of space charge neutralization and ion beam focusing are presented. Keywords: metal ions, vacuum arc plasma, submillisecond beams, high power density.
Analysis of the effect of processing in an ultrahigh frequency electromagnetic field on the interlayer interaction of cured polymer composite materials with various fillers
Authors: Zlobina I.V.  , Bekrenev N.V.  , Churikov D.О.
Published: February 2023

The effect of exposure to a microwave electromagnetic field on samples of cured carbon-, glass-, and organoplastics on an epoxy matrix on the strength and change in the nature of interlayer damage during bending deformations has been studied. An increase in the limiting stresses by 14.5, 9.1 and 11%, respectively, a decrease in the size of the delamination region during deformation by 1.5-2 times and its predominant localization in the internal volume of the composite was established. In the control samples, the exits of interlayer cracks to the surface of the material are noted. Keywords: polymer composite materials, flexural strength, interlaminar shear, damage, microwave electromagnetic field.
Laser pulse energy localization in a photoconductive THz emitter via sapphire fibers
Authors: Ponomarev D. S.  , Lavrukhin D. V.  , Zenchenko N. V.  , Glinskiy I. A.  , Khabibullin R. A.  , Kurlov V. N.  , Zaytsev K. I.
Published: February 2023

We report a seminal approach for localization of photocarriers in a photoconductive antenna (PCA)-emitter via a focusing element comprising the sapphire fiber. Using numerical simulation, we showed that at a certain ratio between the fiber diameter and antenna gap size (d/g~ 22.5), one can attain a ~ 35-fold enhancement of laser irradiation in the vicinity of the PCA electrodes. This provides the formation of subwavelength electromagnetic wave caustics located at the edges of the PCA electrodes, which potentially promotes an increase in the optical-to-terahertz conversion efficiency. Keywords: terahertz frequency, terahertz emitters, semiconductors, photoconductive antenna, IR radiation.
Obtaining glass ceramics of the MgO-SiO-=SUB=-2-=/SUB=- system by the plasma melting method
Authors: Shekhovtsov V. V.  , Volokitin O. G.  , Ushakov V. A.  , Zorin D. A.
Published: February 2023

Results of experimental studies of the synthesis of glass ceramics of the MgO-SiO2 system by plasma melting at the atmospheric pressure are presented. Electron microscopy data showed that, during the melt crystallization with the rate of 287-5 K/s, the surface morphology is represented by a dense packing of rhombic dodecahedral Mg2SiO4 crystals (without open porosity). In this case, the matrix is characterized by the formation of a dense framework with a clear linear arrangement of spherical inclusions corresponding to the MgSiO3 phase. As a result of the plasma melting synthesis, glass ceramics with the density of 3.56 g/cm3 and microhardness of up to 15 GPa was obtained. It is assumed that glass ceramics with such a composition can be considered as an excellent option for the development of a cost-effective high-quality refractory. Keywords: forsterite, glass ceramics, electric arc synthesis.
Electronic spectroscopy of graphene obtained by ultrasonic dispersion
Authors: Kastsova A. G.  , Glebova N. V.  , Nechitailov A. A.  , Krasnova A.O.  , Pelageikina A.O.  , Eliseyev I. A.
Published: February 2023

A technology for obtaining graphene by means of ultrasonic dispersion of thermally expanded graphite in the presence of a surface-active polymer Nafion is presented. The technology makes it possible to obtain large amounts of low-layer (1-3 layers) graphene in a relatively short time. An approach to control the dispersion process based on UV spectroscopy of dispersions is described. A mechanism is proposed for the effect of a surface-active polymer on the production of low-layer graphene by ultrasonic dispersion. Keywords: graphene, ultrasonic dispersion, thermally expanded graphite.
Contexto de cadena maíz
Authors: Castillo Galindo Nicolle Tatiana
Published: February 2023

En esta ficha de contexto se mencionan los aspectos importantes de la cadena de maíz enfocados a su marco productivo, regional, económico, comercio internacional, así como sus perspectivas y tendencias frente al mercado, dando a conocer su entorno de Ciencia y Tecnología e Innovación.
Contexto de cadena cítricos
Authors: Vergara Peña Dais Johanna
Published: February 2023

En esta ficha de contexto se mencionan los aspectos importantes de la cadena de cítricos enfocados a su marco productivo, regional, económico, comercio internacional, así como sus perspectivas y tendencias frente al mercado, dando a conocer su entorno de Ciencia y Tecnología e Innovación.
Tecnologías de secado y potencial de la agroindustria de trozos secos de yuca en el Caribe colombiano
Authors: Rosero Alpala Elvia Amparo , Pérez Cantero Shirley Patricia , Regino Hernández Sol Mara , Martínez Figueroa Remberto Rafael , Taborda Andrade Luis Alejandro , Contreras Valencia Katia , Luna Castellanos Lily Lorena , Ospina Patiño Bernardo , García Ágredo José Alberto , Gallego Castillo Sonia
Published: February 2023

Este manual reúne información relevante para productores y procesa¬dores de yuca, y también puede ser útil para otros actores de la cadena agroindustrial de la yuca, especialmente para quienes participan en las actividades de producción de trozos secos de yuca y en su uso posterior como materia prima en la industria de alimentos balanceados para anima¬les y otros usos industriales. El capítulo 1 describe los resultados de la caracterización de los patios de se¬cado encontrados en los departamentos de Córdoba y Sucre, de la región Ca¬ribe, siendo estos los departamentos de Colombia donde se da el proceso de secado de yuca. Los capítulos 2, 3, 4 y 5 describen las generalidades del proce¬so de secado y las tecnologías usadas en él, indicándose claramente el proce¬so y las condiciones de operación. Finalmente, los capítulos 6 y 7 abordan el potencial de los trozos secos de yuca para la producción de harina refinada, así como también el análisis global y las perspectivas del mercado y de la trans¬formación de trozos secos de yuca en Colombia, aquí se indica la dinámica y el potencial de la región Caribe, que se articula con la demanda de materia prima para la fabricación de alimentos balanceados a nivel nacional.
No-show Prediction Model Performance Among People With HIV: External Validation Study
Authors: Mason Joseph A , Friedman Eleanor E , Rojas Juan C , Ridgway Jessica P
Published: February 2023

Background

Regular medical care is important for people living with HIV. A no-show predictive model among people with HIV could improve clinical care by allowing providers to proactively engage patients at high risk of missing appointments. Epic, a major provider of electronic medical record systems, created a model that predicts a patient’s probability of being a no-show for an outpatient health care appointment; however, this model has not been externally validated in people with HIV.

Objective

We examined the performance of Epic’s no-show model among people with HIV at an academic medical center and assessed whether the performance was impacted by the addition of demographic and HIV clinical information.

Methods

We obtained encounter data from all in-person appointments among people with HIV from January 21 to March 30, 2022, at the University of Chicago Medicine. We compared the predicted no-show probability at the time of the encounter to the actual outcome of these appointments. We also examined the performance of the Epic model among people with HIV for only HIV care appointments in the infectious diseases department. We further compared the no-show model among people with HIV for HIV care appointments to an alternate random forest model we created using a subset of seven readily accessible features used in the Epic model and four additional features related to HIV clinical care or demographics.

Results

We identified 674 people with HIV who contributed 1406 total scheduled in-person appointments during the study period. Of those, we identified 331 people with HIV who contributed 440 HIV care appointments. The performance of the Epic model among people with HIV for all appointments in any outpatient clinic had an area under the receiver operating characteristic curve (AUC) of 0.65 (95% CI 0.63-0.66) and for only HIV care appointments had an AUC of 0.63 (95% CI 0.59-0.67). The alternate model we created for people with HIV attending HIV care appointments had an AUC of 0.78 (95% CI 0.75-0.82), a significant improvement over the Epic model restricted to HIV care appointments (P<.001). Features identified as important in the alternate model included lead time, appointment length, HIV viral load >200 copies per mL, lower CD4 T cell counts (both 50 to <200 cells/mm3 and 200 to <350 cells/mm3), and female sex.

Conclusions

For both models among people with HIV, performance was significantly lower than reported by Epic. The improvement in the performance of the alternate model over the proprietary Epic model demonstrates that, among people with HIV, the inclusion of demographic information may enhance the prediction of appointment attendance. The alternate model further reveals that the prediction of appointment attendance in people with HIV can be improved by using HIV clinical information such as CD4 count and HIV viral load test results as features in the model.
Exploring Patient Journey Mapping and the Learning Health System: Scoping Review
Authors: Joseph Amanda L , Monkman Helen , Kushniruk Andre , Quintana Yuri
Published: February 2023

Background

Journey maps are visualization tools that can facilitate the diagrammatical representation of stakeholder groups by interest or function for comparative visual analysis. Therefore, journey maps can illustrate intersections and relationships between organizations and consumers using products or services. We propose that some synergies may exist between journey maps and the concept of a learning health system (LHS). The overarching goal of an LHS is to use health care data to inform clinical practice and improve service delivery processes and patient outcomes.

Objective

The purpose of this review was to assess the literature and establish a relationship between journey mapping techniques and LHSs. Specifically, in this study, we explored the current state of the literature to answer the following research questions: (1) Is there a relationship between journey mapping techniques and an LHS in the literature? (2) Is there a way to integrate the data from journey mapping activities into an LHS? (3) How can the data gleaned from journey map activities be used to inform an LHS?

Methods

A scoping review was conducted by querying the following electronic databases: Cochrane Database of Systematic Reviews (Ovid), IEEE Xplore, PubMed, Web of Science, Academic Search Complete (EBSCOhost), APA PsycInfo (EBSCOhost), CINAHL (EBSCOhost), and MEDLINE (EBSCOhost). Two researchers applied the inclusion criteria and assessed all articles by title and abstract in the first screen, using Covidence. Following this, a full-text review of included articles was done, with relevant data extracted, tabulated, and assessed thematically.

Results

The initial search yielded 694 studies. Of those, 179 duplicates were removed. Following this, 515 articles were assessed during the first screening phase, and 412 were excluded, as they did not meet the inclusion criteria. Next, 103 articles were read in full, and 95 were excluded, resulting in a final sample of 8 articles that satisfied the inclusion criteria. The article sample can be subsumed into 2 overarching themes: (1) the need to evolve service delivery models in health care, and (2) the potential value of using patient journey data in an LHS.

Conclusions

This scoping review demonstrated the gap in knowledge regarding integrating the data from journey mapping activities into an LHS. Our findings highlighted the importance of using the data from patient experiences to enrich an LHS and provide holistic care. To satisfy this gap, the authors intend to continue this investigation to establish the relationship between journey mapping and the concept of LHSs. This scoping review will serve as phase 1 of an investigative series. Phase 2 will entail the creation of a holistic framework to guide and streamline data integration from journey mapping activities into an LHS. Lastly, phase 3 will provide a proof of concept to demonstrate how patient journey mapping activities could be integrated into an LHS.
Ancaman Intoleransi Terhadap Dasar Negara Pancasila Dan Implikasinya Terhadap Ketahanan Ideologi Wilayah (Studi Di Kabupaten Tasikmalaya, Jawa Barat, Periode 2019-2020)
Authors: Budiman Agus , Taufiq Otong Husni , Nurholis Egi
Published: February 2023

ABSTRAKPancasila merupakan ideologi bangsa Indonesia. Penerapan nilai-nilai Pancasila perlu dilakukan oleh setiap warga negara Indonesia agar terciptanya warga negara yang baik serta mampu mengimplementasikan nilai Pancasila di kehidupan sehari-hari seperti toleransi umat beragama sehingga akan meningkatkan ketahanan nasional. Tujuan penelitian ini yaitu mengetahui sejauh mana ancaman Intoleransi Terhadap Dasar Negara Pancasila dan Implikasinya Kepada Ketahanan Ideologi Wilayah terutama di Tasikmalaya.Penelitian ini menggunakan metode penelitian studi kasus dengan menggunakan berbagai prosedur pengumpulan data untuk menggambarkan respon dari suatu peristiwa pada periode tertentu, Teknik pengumpulan data yang digunakan dalam penelitian ini adalah observasi, wawancara dan dokumentasi sedangkan untuk teknik analisis data pada penelitian ini yaitu reduksi data, penyajian data, dan mengambil kesimpulan.Permasalahan mengenai ketahanan ideologi Pancasila saat ini menjadi polemik bangsa Indonesia. munculnya berbagai isu gerakan pembentukan negara berbasis agama sampai dengan praktik-praktik pemahaman dan perubahan ideologi di berbagai aspek kehidupan sikap intoleransi terhadap umat beragama salah satunya adalah pemahaman agama yang bersifat ekstrinsik Pancasila menjadi sebuah alat pemersatu bangsa Indonesia agar tidak terpecah belah,Pancasila adalah ideologi dan dasar negara kesatuan memiliki nilai yang digali dari Indonesia, artinya digali dan diambil dari kekayaan, rohani, moral dan budaya masyarakat dan bangsa Indonesia. Sikap toleransi harus ditegakkan untuk melawan sikap anti toleransi atau intoleransi yang semakin berkembang. Bhinneka Tunggal Ika dan nilai Pancasila dijadikan dasar dalam upaya membina kerukunan dalam kehidupan bermasyarakat, berbangsa, dan bernegara.
Analisis Pengambail Alihan Tata Ruang Pantai Carita Kabupaten Pandeglang Untuk Mendukung Penanggulangan Bencana Tsunami
Authors: Kurniadi Anwar -
Published: February 2023

The terrible effects of the tsunami disaster in 2018 are almost all damage to infrastructure and environment in the recreation location of Carita Beach. Therefore, it needed to rearrange Carita Beach spatial.This research used method descriptive qualitative. This research analyzes the alternative reasons of Pandeglang Regency to taking over the spatial management of Carita beach to support Tsunami Disaster management.The results of the research were 1) the factors of supporting were old local government regulation based on this research were not suitable anymore and unable to prevent the terrible impact of the tsunami disaster, but with using the regional autonomy authority, the local government has a chance to take over the arrangement of spatial management of Sunda beach; 2) the factor of obstacles were special economic zone area of the central government in Sunda beach and different perception about the authority to manage Carita beach with Province of Banten; 3) the reason of alternatives for taking over were the terrible impact of tsunami disaster to defense and state security, precede the participation of the community in the development program, local government has the authority to give penalty and punishment to the inappropriate use. The conclusion was the local government of Pandeglang Regency makes taking over for rearrangement of the spatial of Carita beach because of relation to regulation and on the fact that the central government could not control it.
Dampak Kampanye #AyoVaksin pada Media Sosial Twitter Terhadap Ketahanan Sosial Masyarakat Indonesia Di Masa Pandemi COVID-19
Authors: Sadayi Delila Putri , Suswanta Suswanta
Published: February 2023

ABSTRAK  Artikel bertujuan untuk menganalisis tingkat ketahanan sosial masyarakat Indonesia melalui seruan kampanye #AyoVaksin di media sosial Twitter selama pandemi COVID-19 di Indonesia.Penelitian ini menggunakan metode analisis data kualitatif (QDA) dengan pendekatan eksploratif. Data sekunder digunakan dalam penelitian ini; dataset #Ayovaksin yang dikumpulkan dari media sosial Twitter dan data bersumber dari 25 berita media online nasional dari tahun 2021-2022. Data yang telah dikumpulkan kemudian dianalisis untuk mengidentifikasi variabel penelitian menggunakan perangkat lunak Nvivo 12 plus.Hasil penelitian menunjukkan bahwa; 1) Seruan #Ayovaksin di Indonesia memiliki mobilitas interaksi rata-rata berfluktuasi dengan tagar. 2) Seruan vaksin didominasi oleh akun palsu/anonim diidentifikasi sebagai akun buzzer, aktif dalam memperbarui isu vaksin, dan aktivitas kerja akun berpola berpengaruh terhadap kontrol sosial. 3) Ajakan kampanye vaksinasi COVID-19 melalui #Ayovaksin terbukti tidak efektif, di mana media sosial memiliki kerentanan terhadap penyebaran informasi palsu (hoaks). 4) seruan #AyoVaksin tidak berpengaruh terhadap ketahanan sosial di masyarakat, sebab kontribusi dalam seruan vaksin melalui tagar #AyoVaksin tidak berjalan efektif karena didominasi oleh akun anonim. Masyarakat diharapkan dapat mengoptimalkan media sosial sebagai sarana kontrol sosial; dengan kata lain, masyarakat bisa lebih bijak dalam menggunakan media sosial
Identification and Exploitation Process of Entrepreneurial Opportunities in Micro and Small Enterprises in Chapada da Ibiapaba – Ceará – Brazil
Authors: Aguiar Talita Souza , Moraes Marcela Barbosa de , Portela Francimeire Farrapo , Souza José Roberto Ferreira de
Published: February 2023

With the increase in the number of companies in the last ten years, exploring and identifying opportunities in business creation, with the aim of making them lasting, profitable and successful, has become difficult. The general objective of this research is to understand the process of exploring and identifying opportunities for leading restaurant owners in creating their businesses, from the perspective of effectuation and causation theories, according to Sarasvathy (2001). To achieve the objective of the study, qualitative research of descriptive character was carried out. Data were collected through interviews, with the application of an individual semi-structured questionnaire carried out with four managing owners. For data analysis, the recommendations of Eisenhardt (1989) were followed, which seeks to carry out a data triangulation and analyzes between crossed cases according to the established variables. For the analysis of the dominant logic in the perception of the managing owners during the entrepreneurial process, the Iramuteq software was used to identify the frequency and similarity of the words found in the interviews. As a result of the research, a predominance of the causation profile was found in the business creation process. In the categories of planning process, influence on the idea and predisposition to risks and resource losses, an effectuation profile was identified. Finally, it is possible to state that most of the interviewed managing owners explore and identify opportunities, presenting behaviors of the effectuation profile in the decision-making processes, with the causation profile being identified only in the creation of the enterprise.
Contextualising Appraisal and the Destruction of the Soviet Design Institute’s Archives
Authors: Litvinenko Ksenia
Published: February 2023

Recently, historians and theorists of architecture have started questioning the neutrality of traditional archival research methods by uncovering the operations of power and authority inherent to the creation, appraisal, accessioning, or erasure of historical documents and the institutionalisation of official and unofficial archives. Most of this research is based on analyses of archiving in Euro-American and (post-) colonial contexts; consequently, there is limited understanding of the politics and practices of archiving architecture in both former and current state-socialist countries. The paper addresses this lacuna by exploring different ways of archiving a single design practice, the Giproteatr Institute, one of the central organisations behind the construction of buildings for culture and the performing arts in the Soviet Union and beyond. By reconstructing the changing material and economic conditions of architectural labour in the late Soviet and immediate post-Soviet periods, precedents of authorised and unauthorised destruction of architectural documents, archival regulations, and appraisal procedures, the paper demonstrates that Giproteatr Institute’s archives are in themselves historical and carry different definitions of archival value and of the architectural profession. Therefore, the paper further problematises the notion of ‘evidence’ in architectural history and advocates for strengthening the focus on analysis of material processes of archiving.
¿Quién aprueba el matrimonio igualitario en México?
Authors: Álvarez Reyes José Ángel , Castro Cornejo Rodrigo
Published: February 2023

En México, el reconocimiento legal del matrimonio entre personas del mismo sexo comenzó en la capital del país hace doce años. Después de esta reforma, la legislación sobre el matrimonio igualitario ha avanzado y enfrentado distintos obstáculos a nivel nacional. Este artículo examina el desarrollo y estado actual de la opinión pública con respecto al matrimonio igualitario en México por medio de teorías basadas en la modernización, el cambio generacional, las actitudes políticas y la religión. Con el objetivo de poner a prueba nuestras hipótesis, esta investigación utiliza datos de LAPOP en sus distintos levantamientos (2010-2018) para realizar una serie de modelos de regresión lineal. Los hallazgos señalan que mayores niveles educativos, ser más joven y habitar en zonas urbanas aumenta la probabilidad de apoyar el matrimonio igualitario. Por el contrario, aquellas personas que forman parte de grupos evangélicos tienen mayor probabilidad de estar en desacuerdo que las personas sin religión o los católicos. En términos generales, se observa una tendencia de apoyo creciente por el matrimonio igualitario en México.
Skin Disease Detection Using Machine Learning
Authors: Ahir Harsh , D Chandu , Kumar Rohit , karthik Harshvardhan , Sunanda Assistant Prof.
Published: February 2023

Abstract: Particularly dangerous and frequently contagious include melanoma, eczema, and impetigo. When found early enough, some skin conditions are curable. The main issue with it is that only a skilled dermatologist can identify and categorise such diseases. In several cases, medical professionals appropriately categorise the illness and consequently give the patient the wrong drugs. Navies Bias Classifier has been contrasted. Real-time testing findings are displayed. Since our solution is mobilebased, it can be used anywhere. In order for the programme to function, the patient must supply an image of the affected area. It is processed using deep learning techniques and produces the most accurate results. In this essay, we compare two distinct real-time skin disease detection algorithms based on accuracy in this presentation.
Improving Students’ Vocabulary Through Paper-Mode Quizizz: A Classroom Action Research in Indonesian EFL setting
Authors: Putra Rizal Wahid Permana
Published: February 2023

Vocabulary is an essential component in learning a second or a foreign language. It is one of the most important aspects of obtaining all four language skills; reading, listening, speaking, and writing. Therefore, teaching and learning vocabulary should be done through various-interactive media so that children are interested in acquiring it. Integrating gamefication-based learning media can be utilised to support the teaching-learning vocabulary. In addition, Paper-Mode Quizziz can be used as a game-based learning platform offering multiple tools to make a classroom fun, interactive, and engaging in learning vocabulary. This research aimed at investigating the use of Paper-Mode Quizizz to improve students’ vocabulary at eighth grade students. This research was Classroom Action Research conducted at eighth grade students. The research subject was 8C grade students of SMP SSA Negeri Kloposawit 1 Candipuro. Further, this research was conducted in two cycles. In cycle I, the researcher found that the eighth-grade students’ vocabulary mastery was improved. The average score was 72,4. Further, in cycle II, the eighth-grade students’ vocabulary mastery was much better than in cycle II. the average score was 81,4. It showed that the use of Paper-Mode Quizizz profoundly improved the eighth-grade students’ vocabulary mastery. In addition, the students were more enjoyed, actively participated, highly motivated, and engaged with the use of Paper-Mode Quizizz in learning new vocabularies. In short, the implementation of Paper-Mode Quizizz profoundly improved the students’ vocabulary mastery at eighth-grade students in learning English.
The effectiveness of formulation of Lantana camara-based insecticides on looper caterpillar (Hyposidra talaca, Ectropis bhurmitra, Biston suppressaria) on tea plant
Authors: Rayati Dini Jamia
Published: February 2023

To obtain an environmentally sound control method of looper caterpillar (Hyposidra talaca, Ectropis bhurmitra, Biston suppressaria) as an alternative to reduce the use of chemical insecticide in tea estate, a study to evaluate the effect of the formulation of L. camara-based insecticide against looper caterpillar on tea plant has been conducted at Pasir Sarongge Experimental Garden (1,100 m asl), Cianjur, West Java. The trial was arranged in a randomized complete block design with six treatments, replicated four times. The treatments comprised: Formulation WP of L. camara-based insecticide with two doses, 1,5 kg/ha and 3,0 kg/ha; Formulation EC of L. camara-based insecticide with two doses, 1,5 l/ha and 3,0 l/ha; Standard chemical insecticide, Decis 25 EC (deltaÂ­metrin) at 300 m/ha; and control. The L. camara-based insecticide and chemical insecticide were sprayed three times with one week interval, one day after plucking. The intensity of looper caterpillar attack was measured every week after spraying at the time of plucking. Results showed that all of the L. camara-based insecticide formulation treatments were effective against tea-looper caterpillar. The effectiveness in reducing the intensity of looper caterpillar attack were not significantly different each others, and were comparable to the standard chemical insecticide. The effectiveness level were relatively high, with the average of 45,25%. Based on these results it could be concluded that both formulation of WP and EC of Â L. camara-based insecticide could be used for controlling tea-looper caterpillar at lower dose, i.e. 1,5 kg/ha and 1,5 l/ha for the formulation of WP and EC, respectively.
МОНГОЛ УЛС ШАНХАЙН ХАМТЫН АЖИЛЛАГААНЫ БАЙГУУЛЛАГЫН ГИШҮҮНЭЭР ЭЛСЭХ ЭСЭХ АСУУДЛЫГ ЭДИЙН ЗАСГИЙН ХАМТЫН АЖИЛЛАГААНЫ АСПЕКТААР ШИНЖЛЭХ НЬ
Authors: Д.Ундрах  , Д.Ууганжаргал
Published: February 2023

Зүүн хойд Ази болон Төв Азийн бүс нутагт орших Монгол улс Шанхайн Хамтын Ажиллагааны Байгууллага (ШХАБ)-д 2004 оноос эхлэн ажиглагчийн статустай яриа хэлцэлд идэвхитэй оролцсоор ирсэн. Тус байгууллага нь аюулгүй байдал, цэргийн хамтын ажиллагаа чиглэлд илүү хөгжих төлөвтэй, улс төрийн яриа хэлцэл давамгайлсан бүсийн нутгийн байгууллага болж төлөвших хандлагатай. Монгол улс ШХАБ-д элссэн тохиолдолд худалдаа, хөрөнгө оруулалт, тарифын хөнгөлөлт, тусгайлсан төсөл хөтөлбөрийн хувьд эдийн засгийн ямар үр өгөөжтэй байх нь тодорхойгүй хэвээр байна. Энэхүү судалгааны ажлын дүнд Монгол улс нь ШХАБ-д элсэхгүйгээр ажиглагчийн статусаа хэвээр хадгалах нь тохиромжтой хэмээн үзсэн болно.
Protegiendo la mente: un análisis al concepto de lo mental en la ley de neuroderechos
Authors: Lopez-Silva Pablo , Madrid Raúl
Published: February 2023

Luego de examinar algunos de los aspectos más fundamentales respecto del concepto general de ‘neuroderecho’ en la discusión mundial actual, este artículo analiza el concepto de ‘lo mental’ contenido en la primera ley de Neuroderechos en el Mundo en actual proceso de discusión en el Senado de Chile (Boletín N° 13.828-19 del Senado de la República de Chile). Se señala que la caracterización del concepto en cuestión no solo podría dificultar la creación de marcos legales específicos respecto de la protección de los sujetos ante el mal uso de neurotecnologías, sino que también podrían oscurecer la toma de decisiones en torno a la interpretación de la ley.
Cambio conceptual e innovación técnica: los desafíos de las neurociencias a la filosofía de las revoluciones científicas
Authors: Barberis Sergio Daniel
Published: February 2023

El papel determinante que desempeña la innovación técnica en el progreso neurocientífico plantea desafíos especiales a la filosofía del cambio científico de raigambre kuhniana. Algunos filósofos de la neurociencia sostienen que las revoluciones en neurociencia no involucran cambios de paradigma, sino que dependen exclusivamente de la innovación técnica o experimental. Mediante el estudio del episodio histórico del descubrimiento de la neurona (1873-1909), argumento que las revoluciones en neurociencia, como muchas otras revoluciones de laboratorio, están frecuentemente impulsadas por el entrelazamiento de innovaciones técnicas y cambio conceptual.
En defensa de un diálogo entre las neurociencias y las éticas normativas: ¿Mejoramiento moral mediante oxitocina en aerosol?
Authors: Garcia Valverde Facundo , Fatauros Cristian Augusto
Published: February 2023

En este trabajo sostenemos que debería existir un diálogo (que excluye la subordinación y la independencia) entre las neurociencias y las éticas normativas. Nuestro argumento toma como base que los conocimientos provenientes de la neurociencia (y, en particular, los estudios sobre el rol causal de la oxitocina en el comportamiento humano) pueden explicar y dar contenido a algunos límites motivacionales y psicológicos que modificarían las exigencias morales de los individuos. Mostramos que ante un caso hipotético que propone la mejora moral mediante la aplicación de oxitocina en aerosol, los argumentos neuroéticos, por sí solos, son insuficientes para determinar su permisibilidad o impermisibilidad moral. Además, defendemos que tampoco es posible establecer la superioridad de los argumentos de ética normativa, ya que los conocimientos de la neurociencia son más efectivos para modificar las conductas limitadas por nuestra propia constitución física y neurológica. Concluimos que tanto unos como otros sirven para tomar decisiones, tanto individuales, como colectivas, para tratar de acomodar mejor nuestras actitudes y comportamientos a lo que consideramos moralmente correcto hacer.