bluuebunny/crossref_metadata_2025 huggingface dataset:
Key contributors and trends in circulating tumor DNA research in lung cancer: A bibliometric analysis
Authors: Su Lin , Bai Xueli , Zhang Xiaohong , Cheng Jiande , Ding Jie , Wei Shuang , Li Xiaochen , Liu Xiansheng
Published: February 2025

Lung cancer is one of the leading causes of cancer-related mortality, and liquid biopsy, particularly the detection of circulating tumor DNA (ctDNA), offers a promising non-invasive alternative for diagnosis. Despite significant research on ctDNA in lung cancer, a comprehensive bibliometric analysis on this topic is lacking in the literature. This study systematically reviews ctDNA research trends in lung cancer using bibliometric methods to identify leading contributors, emerging themes, and underexplored areas for future research. We conducted a search of the Web of Science Core Collection database for ctDNA-related lung cancer publications up to 2023. The bibliometric analysis was performed using VOSviewers, CiteSpace, and the R package “bibliometrix.” The results revealed a total of 2862 publications on ctDNA in lung cancer, comprising 1998 articles and 864 reviews. Between 2021 and 2023, the number of publications stabilized, with an average of approximately 360 publications per year. The countries with the highest number of published papers were China and the United States. The University of Texas MD Anderson Cancer Center was the leading institution in terms of publication output. Among journals, Cancers published the highest number of papers, while Clinical Cancer Research had the highest citation impact. Lanman RB was the leading author by publication count, and Newman was the most co-cited author. Current research on ctDNA in lung cancer primarily focuses on areas such as minimal residual disease, prognosis and recurrence monitoring, adjuvant therapy decision-making, epidermal growth factor receptor and targeted therapy, and immunotherapy. This bibliometric analysis highlights the impact of ctDNA in lung cancer, revealing key contributors and emerging research trends.
Survey findings in a health-promoting university campus in Northern Germany: Monitoring students’ health awareness and needs
Authors: Kolovou Vasiliki , Dierckens Delphine
Published: February 2025

This study examines the implementation of a health-promoting project in a university faculty campus in northern Germany, involving students enrolled in nursing and health care, social work, and inclusive education programs, both in full-time and vocational tracks. The study explores students’ current level of awareness regarding the main health-promoting activities through a baseline survey. The survey’s primary objective was to inform and enhance the university’s existing student health activities. This paper outlines the study design and presents the descriptive findings of the baseline survey data, focusing on students’ awareness, involvement, and needs on campus. The survey represents a practice-oriented approach to actively monitor students’ needs while raising awareness about health promotion within the university environment.
Sickle cell disease: A 75-year journey
Authors: Bolo Samira , Mishra Tulika , Eziri Uzoamaka , Leon Tiara Calvo , Mankar Deepti , Navarrete Frank , Khan Abrar , Bhat Malpe Surekha
Published: February 2025

Sickle cell disease (SCD) is a disorder characterized by the polymerization of hemoglobin chains in the deoxy-form, sickling of red blood cells, and hence vaso-occlusive crisis, multiple organ damage, and increased mortality due to an inherited defect in hemoglobin structure. SCD can also lead to a host of complications, which include acute chest syndrome, avascular necrosis, stroke, pulmonary hypertension, splenic sequestration, gallstones, deep vein thrombosis, pregnancy complications, and end-organ damage. Complications are of varying complexities and can be as grave as life-threatening. According to a report in 2005, the median life expectancy for male and female patients with SCD in the United States (US) was around 42 and 38 years, respectively. However, the survival rate of SCD patients in high-income countries has steadily improved. Treatment options that were mainly for symptomatic relief and led to better well-being of the patient, containment of complication recurrence, and decrease in mortality rates have evolved into curative treatment options such as stem cell transplantations and gene therapy. The present paper is a review of the disease, its complications and implications on the community, and a historical tracking of the evolution of treatment options up to modern-day gene therapy.
Preclinical evaluation reveals comparable toxicology and pharmacology of the erythropoietin biosimilar GBpoietin® and Eprex®
Authors: Nag Kakon , Mohiuddin Mohammad , Rahman Khan Md. Maksudur , Kumar Samir , Haq Sarker Md. Enamul , Biswas Bipul Kumar , Haq Sheikh Rejaul , Bachar Sitesh Chandra , Sultana Naznin
Published: February 2025

Erythropoietin (EPO) is an essential growth factor for erythropoiesis. We report the results of the preclinical safety evaluation of GBpoietin®, a recombinant human EPO (rhEPO), through a comparative acute toxicity study with the reference product, Eprex®. The products were administered subcutaneously into Wistar rats for both the single-dose and repeated-dose toxicity studies. Hematological and biochemical parameters were measured for all test subjects before the first dose and the day after the last dose in both studies. Necropsy and histopathology of representative subjects from each group were also performed to find any pathological changes, such as degeneration or cellular necrosis in internal organs such as the kidney, liver, lung, and spleen. Both GBpoietin® and Eprex® comparative toxicology studies, which were not significantly different (P > 0.05), revealed similar pharmacologically driven mechanisms of toxicity. Although hematological parameters stayed within the normal range throughout the study, improved profiles of hemoglobin and hematocrit (P < 0.05) confirmed the therapeutic effect of rhEPO in both studies. Moreover, the initial and final values of aspartate aminotransferase, alanine aminotransferase, and blood urea nitrogen were comparable (P > 0.05) for both experimental products. The study established that the toxicological profiles of GBpoietin® and Eprex® were similar and aligned with the known pharmacology of EPO alfa, demonstrating proof of “totality” and “no residual uncertainty.”
Intracerebral drug delivery using microbubble/nanodroplet-assisted ultrasound to address neurodegenerative diseases
Authors: Ea Karen , Taulier Nicolas , Contino-Pépin Christiane , Urbach Wladimir , Desgranges Stéphane , Blasco Hélène , Al-Ojaimi Yara , Corcia Philippe , Vourc’h Patrick , Escoffre Jean-Michel
Published: February 2025

Background: The blood–brain barrier (BBB) is a selective and semi-permeable barrier essential for protecting the brain’s parenchyma against pathogens and toxic molecules present in the bloodstream. It consists of a monolayer of brain capillary endothelial cells, pericytes, astrocytic end-feet, and neurons. The tight junctions between endothelial cells prevent paracellular transport, further reinforcing its selectivity. However, this high level of selectivity represents a significant challenge for the delivery of therapeutic molecules to the central nervous system. Aim: Microbubble-assisted ultrasound (US) is a promising strategy for transiently permeabilizing the BBB to enable safe, non-invasive, localized, and efficient drug delivery to the brain. This approach enhances drug extravasation and bioavailability. Recently, nanodroplets (NDs) have emerged as good candidates to replace MBs. The aim of this review is to provide an updated overview of the rapidly expanding field of MB/ND-assisted US for the treatment of neurodegenerative diseases. This exciting field bridges research in biology and chemistry (MBs, NDs), US technology and the development of new drugs, small molecules, and biomedicines. The review begins with an update on MBs and NDs and discusses laboratory-manufactured and clinically approved devices such as Sonocloud®, NaviFUS®, and ExAblate Neuro®. It then focuses on the potential use of MB/ND-assisted US in treating neurodegenerative diseases, particularly Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis, and Huntington’s disease (HD). Relevance for patients: Acoustically mediated BBB opening is an innovative and rapidly advancing strategy that holds great promise for improving the efficacy of existing treatments for neurodegenerative diseases. It also facilitates the discovery of new therapeutic molecules by enhancing their delivery to the brain.
From Home to Campus: Unveiling Parents' Perspectives on the Resumption of In-Person Classes in Higher Education
Authors: Comampong Normena M. , Tagare Jr. Ruben L. , Calixtro Marichu A. , Orfrecio Marlene E. , Esponja Joanna Caryl P. , Landawe Bae Kellah Kassandra , Janito Cheeze R. , Martinez Norge D.
Published: February 2025

Purpose of the Study: This study explores the challenges faced by parents during the full implementation of in-person classes at the tertiary level and examines their suggestions for improving this transition.
Methodology:  The study employed a qualitative descriptive research design. In-depth interviews were conducted with ten parents using a guided questionnaire to gather comprehensive insights. Triangulation was used to ensure the reliability and accuracy of the findings.
Main Findings: The study highlights the resourcefulness and determination of parents in supporting their children's college education. It uncovers not only tangible successes—such as academic achievements and career prospects—but also narratives of resilience, creativity, and unwavering commitment in overcoming financial, emotional, and unforeseen challenges.
Novelty/Originality of this Study: The study presents untold stories of parents' experiences, offering unique perspectives on their struggles and triumphs. These insights can inspire educational practices and policies that better address the needs of families supporting tertiary education in a post-pandemic context.
Comic-Polya Method Integration in Physics: Enhance Students' Conceptual Understanding and Motivation
Authors: Gardose Charmagne Kris C. , Castillo Arlene A. , Madroñal Melvin H.
Published: February 2025

Purpose of the study: Filipino students' declining science performance calls for innovative instructional methods. This study evaluated the effects of integrating comic-based instruction and the Polya Method in Grade 8 Physics lessons at Opol National Secondary Technical during the 2023–2024 school year.
Methodology: Thirty-six students were selected using convenience sampling. Employing a mixed-method approach, this study used a one-group pre-test and post-test design and focus-group discussions for qualitative data. Conceptual understanding and science motivation were assessed over one month using a 30-item pre- and post-test aligned with the Department of Education competencies.
Main Findings: Pre-test results from 86.11% of students who needed improvement categories were high. After the intervention this percentage distribution decreased to 13.89%, with improvements in the categories of satisfactory (30.56%) and outstanding (13.89%). Qualitative analysis indicated increased science motivation (moderately high to high), and thematic analysis revealed enhanced engagement, enjoyment, academic performance, and problem-solving skills. Post-intervention, mean test scores rose from 11.31 to 19.69 (t = 13.786, P = 0.0001), demonstrating the effectiveness of combining comic-based learning with Polya's method.
Novelty/Originality of this study: This research presents newly gained perspectives on incorporating comic-based learning and the Polya Method to enhance the conceptual understanding and science motivation of Filipino secondary students in selected Physics lessons. Thematic analysis unveiled three unique themes that contribute to the science education research literature focused on the Philippines and these strategies.
Review: Ethnobotanical Studies in West Kalimantan as Biology Learning Resources
Authors: Faturrahman Mas Akhbar , Wahyuni Dina , Asyrofi Harun , Sandra Klaudia Mareta , Ningsih Kurnia , Afandi Afandi , Syamswisna Syamswisna
Published: February 2025

Purpose of the study: This research aims to present concise information related to implementing ethnobotanical research in West Kalimantan as a biology learning resource.
Methodology: This research is classified as qualitative research with the type of literature review. Each scientific article found during the search process is then analyzed, and the results are presented as tables and graphs.
Main Findings: Based on the search, 63 scientific articles implement ethnobotanical research in West Kalimantan as a learning resource in biology subjects. The ethnobotanical research includes using plants as medicine, cosmetics, crafts, dyes, traditional ceremonies, boards, food, wrappers, and toys. The learning resources developed include 13 non-digital and 8 digital learning resources.
Novelty/Originality of this study: This research is unique in that it presents literature studies related to the implementation of ethnobotanical research, specifically in West Kalimantan, as a biology learning resource.
Analysis of the Effectiveness of Online Learning Based on Google Classroom on High School Students' Learning Achievement
Authors: Doranggi Selvina , Rizka Ardiana
Published: February 2025

Purpose of the study: This study employs a qualitative descriptive approach using a systematic literature review. Data were collected from scientific journal articles published between 2020 and 2022. The analysis follows the framework of data reduction, data display, and conclusion drawing to synthesize findings on the impact of Google Classroom on students' learning outcomes.
Methodology: This study employs a qualitative descriptive approach using a systematic literature review. Data were collected from scientific journal articles published between 2020 and 2022. The analysis follows the framework of data reduction, data display, and conclusion drawing to synthesize findings on the impact of Google Classroom on students' learning outcomes.
Main Findings: The findings indicate that Google Classroom significantly enhances students' academic performance, motivation, and engagement. The platform provides flexibility in accessing learning materials, facilitates student-teacher interactions, and supports independent learning. Additionally, Google Classroom fosters active participation, improves discipline in assignment submission, and enhances digital literacy among students.
Novelty/Originality of this study: This study contributes to the existing body of knowledge by providing a comprehensive review of Google Classroom's effectiveness in online learning. It highlights the platform's role in fostering student engagement and improving learning outcomes while addressing the challenges of digital education. The findings serve as a valuable reference for educators and policymakers in optimizing online learning strategies.
The Effectiveness of Limnobium laevigatum in Inhibiting the Growth of Microbes Found in Lake Water
Authors: Teryna Thu Pui Xing  , Teo Swee Sen
Published: February 2025

Limnobium laevigatum, commonly called Amazon frogbit, belongs to the Hydrocharitaceae family and thrives in freshwater environments with abundant lighting. This perennial herb has a unique characteristic of floating above the water’s surface but can also establish roots in shallow water. Several studies showed that the roots of L. laevigatum have high removal efficiencies of heavy metals in wasted water up to a concentration of 70%, particularly Zn. However, the investigation of L. laevigatum to treat microorganisms in contaminated water still needs to be explored. After serial dilution, a lake water sample was isolated to identify the types of microbes. Gram-staining was applied as a preliminary analysis for further identification of the types of microbes by observing under a compound microscope. Following identification, 6 gram-positive and 4 gram-negative bacteria were tested with different amounts of L. laevigatum powder, 0.1 g, 0.2 g, and 0.3 g using a mass spectrophotometer to determine the effectiveness of inhibiting the growth of selected microbes. Gram-staining revealed that 66% of isolates are categorized as gram-positive bacteria, while 34% are gram-negative. Further observation shows that 75.75% of isolates from gram-positive bacteria are bacillus-shaped, and 24.25% are cocci-shaped among all gram-positive. 0.1 g of powder shows the least effect on inhibiting Gram-positive bacteria growth, whereas 0.3 g of powder shows the most impact on bacteria. Graphs with standard deviation (SD) values were plotted to compare the effectiveness between different concentrations of L. laevigatum and the differences between Gram-positive and Gram-negative bacteria. The antimicrobial properties of L. laevigatum show minimal effect on Gram-negative than Gram-positive bacteria. This research aims to assess the efficacy of L. laevigatum for inhibiting microbes’ growth, offering practical applications for sustainable water treatment, contributing to eco-friendly solutions, and promoting environmental sustainability.
Bifurcation Analysis and Quenching Chaos in Brushless DC Motor Based on Dither Signals
Authors: Chang Shun-Chang
Published: February 2025

This study investigates bifurcation and chaos dynamics in brushless direct current (DC) motor (BLDCM) through analyses of time response, Poincare' maps and frequency spectra. A chaos suppression approach is then proposed and detailed. To identify the initiation of chaotic motion in BLDCM, Lyapunov exponents and dimensions are utilized. Subsequently, the study implements the suggested method by introducing an external input, referred to as a dither signal, into the chaotic BLDCM system. The effectiveness of the proposed control method was determined by simulations.
Moore-Penrose Pseudo-Inverse Applied to the Decoding of 5G and Beyond (B5G) Communication Systems
Authors: Vidal-Beltrán Sergio , Lopez-Bonilla Jose Luis , Montiel-Pérez Jesús Yalja , Pérez-Sánchez Grethell Georgina
Published: February 2025

This work uses the Moore-Penrose pseudo-inverse (PINV) properties to improve the decoding of signals in the uplink channel of a 5th-Generation mobile communication technology (5G) and Beyond (B5G) communication system. The results of computational simulations show an improvement in the bit error rate (BER) and in the Error Vector Magnitude (EVM) under adverse conditions of the wireless communication channel, which is of great importance to meet the high transmission rate and high reliability requirements of 5G and B5G systems.
PENGARUH LATIHAN FLEKSIBILITAS (SPLIT) TERHADAP TINGGI TEKNIK TENDANGAN DOLLYO CHAGI PADA ATLET TAEKWONDO
Authors: Hariadi Nopi , Febiyola Sherly Ardista , Nopiana Rina , Hariadi Hariadi , Suryansah Suryansah
Published: February 2025

Penelitian ini bertujuan untuk mengetahui apakah ada pengaruh latihan fleksibilitas terhadap tinggi tendangan Dollyo Chagi. Penelitian menggunakan desain eksperimen dengan pretest dan posttest. Populasi dalam penelitian ini adalah seluruh Atlet Taekwondo Dojang STC (Spensaker Taekwondo Club) sebanyak 20 atlet. Teknik sampling yang digunakan adalah purposive sampling, yaitu teknik pengambilan sampel dengan menggunakan kriteria tertentu dan yang memenuhi syarat sebanyak 15 atlet Dojang STC. Hasil penelitian menunjukkan bahwa terdapat pengaruh latihan fleksibilitas (split) terhadap tinggi tendangan Dollyo Chagi, dapat dilihat dari hasil peningkatan rata-rata pretest maupun posttest. Rata-rata pretest adalah 6,27, kemudian setelah diberikan perlakuan selama 16 pertemuan dengan latihan fleksibilitas (split) terjadi peningkatan yaitu menjadi 7,6 dan hasil uji t-Test menunjukkan nilai Thitung Ttabel atau 10,583 2,144. Berdasarkan hasil penelitian, dapat disimpulkan bahwa latihan fleksibilitas (split) memberikan pengaruh yang signifikan terhadap tinggi tendangan Dollyo Chagi. Penelitian ini memberikan kontribusi untuk tambahan wawasan dan referensi bagi pelatih maupun atlet dalam mempertimbangkan salah satu faktor keberhasilan dalam melakukan teknik tendangan Dollyo Chagi yang tinggi yaitu dengan latihan fleksibilitas (split) dan latihan ini dapat dimasukkan dalam program latihan di Dojang STC.
IMPLEMENTASI MEDIA PEMBELAJARAN PREZI TERHADAP KREATIVITAS MAHASISWA PENDIDIKAN JASMANI KESEHATAN DAN REKREASI
Authors: Ladjar Maria Andriani Barek , Wijaya I Nyoman Wahyu Esa , Neolaka Erwin Sarnoto
Published: February 2025

Penelitian ini bertujuan untuk menganalisis Implementasi Media Pembelajaran Prezi Terhadap Kreativitas Mahasiswa Program Studi Pendidikan Jasmani Kesehatan dan Rekreasi (Penjaskesrek), Fakultas Keguruan dan Ilmu Pendidikan (FKIP), Universitas Nusa Cendana (Undana) Kupang. Populasi dalam penelitian ini adalah mahasiswa Penjaskesrek FKIP semester II dan IV Undana sebanyak 200 orang mahasiswa. Teknik pengambilan sampel adalah purposive sampling dimana sampel dipilih berdasarkan pertimbangan tertentu, yaitu sampel merupakan mahasiswa aktif semester II dan IV memiliki perangkat laptop, notebook atau perangkat yang menunjang praktik media pembelajaran, dan memiliki pemahaman dasar tentang pengaplikasian device laptop maupun notebook. Sampel penelitian sebanyak 40 orang. Sebelum dan setelah diberikan perlakukan melalui Media Pembelajaran Prezi, dilakukan tes penugasan dengan cara mahasiswa membuat media pembelajaran dengan kreativitas mereka sendiri untuk mengukur kemampuan kreativitas. Sehingga diperoleh dua data yaitu data pre-test dan data post-test. Maka design penelitian yang digunakan yaitu One Group Pre-Post Test Design. Temuan dari penelitian ini terdapat pengaruh dari media pembelajaran prezi terhadap kreativitas dan besarnya pengaruh diperoleh melalui uji regresi sederhana yang menunjukan nilai koefisien determinasi (R Square) sebesar 0,608 yang memiliki arti bahwa pengaruh variabel bebas (media Prezi) terhadap variabel terikat (kreativitas) adalah sebesar 60,8 %. Maka dapat disimpulkan bahwa, media pembelajaran Prezi dapat digunakan sebagai salah satu solusi untuk meningkatkan kreativitas mahasiswa. Implikasinya dari penelitian ini, sampel penelitian sudah dibekali oleh kreativitas melalui media pembelajaran prezi yang bisa berguna selama proses perkuliahan maupun kelak saat sudah terjun di dunia pendidikan sebagai seorang guru Pendidikan Jasmani Olahraga dan Kesehatan (PJOK).
MANAJEMEN SUMBER DAYA OLAHRAGA PADA CABANG OLAHRAGA BELA DIRI: LITERATURE REVIEW
Authors: Putri Ariza , Rasyid Rosyeni
Published: February 2025

Manajemen sumber daya olahraga memiliki peran penting dalam pengembangan atlet dan pencapaian prestasi, terutama dalam cabang olahraga bela diri seperti karate, judo, taekwondo, dan kickboxing. Penelitian ini bertujuan untuk mengeksplorasi aspek-aspek manajemen sumber daya olahraga yang mempengaruhi kinerja atlet bela diri, dengan meninjau literatur yang relevan. Faktor-faktor utama yang dibahas meliputi dukungan finansial, fasilitas pelatihan, kualitas pelatih, kesejahteraan mental atlet, dan kepemimpinan yang efektif. Penelitian ini menggunakan pendekatan tinjauan pustaka, dengan mengumpulkan artikel dari database ilmiah seperti Scopus, PubMed, dan Google Scholar, menggunakan kata kunci seperti "Manajemen", "Sumber Daya", "Olahraga", dan "Bela Diri". Data yang diperoleh dianalisis untuk menyimpulkan berbagai strategi manajemen yang dapat diterapkan untuk meningkatkan kinerja dan kesejahteraan atlet. Temuan penelitian menunjukkan bahwa manajemen yang buruk, seperti ketidaktersediaan dana yang cukup, fasilitas yang tidak memadai, dan kurangnya dukungan terhadap transisi karier atlet pasca-kompetisi, dapat menghambat kemajuan atlet dan olahraga bela diri secara keseluruhan. Kepemimpinan transformasional yang baik, yang mendorong kohesi tim dan motivasi atlet, terbukti meningkatkan performa, meskipun olahraga bela diri sering kali dianggap sebagai cabang individu. Selain itu, perhatian terhadap kesejahteraan psikologis, seperti melalui praktik mindfulness, dapat mengurangi stres dan meningkatkan kinerja atlet. Penelitian ini menyarankan perlunya sistem manajerial yang terstruktur dan terkoordinasi untuk mengatasi tantangan yang ada, terutama di negara berkembang. Keberhasilan jangka panjang dalam olahraga bela diri memerlukan perhatian holistik terhadap aspek finansial, pelatihan, fasilitas, kepemimpinan, dan kesejahteraan mental atlet.
Prognostic value of HLA class I expression in patients with cutaneous melanoma and soft tissue sarcomas treated with cancer-testis antigens-based vaccine
Authors: Nekhaeva Tatiana L. , Novik Aleksei V. , Girdyuk Dmitry V. , Danilova Anna B. , Savchenko Polina A. , Grigoryevskaya Alina V. , Nekrasova Maria A. , Efremova Natalia A. , Orekhov Andrey V. , Baldueva Irina A.
Published: February 2025

Aim: To assess the predictive and prognostic role of HLA class I expression in patients with melanoma (Mel), and soft tissue sarcomas (STS) treated with autologous dendritic cell vaccine (DCV) (CaTeVac).
Methods: From 2009 to 2023, 277 patients with Mel (143), and STS (134), received DCV at the N.N. Petrov National Medical Research Center of Oncology in adjuvant (78.3% and 14.9%) and therapeutic (21.7% and 85.1%) setting. HLA-typing was performed using a polymerase chain reaction with sequence-specific primers (PCR-SSP). Progression-free survival (PFS) and overall survival (OS) grouped by the presence of HLA alleles or HLA association rules were assessed using the Kaplan-Meier method (medians of survival in the month are presented).
Results: Higher OS (41.1 vs. 22.1, P = 0.026) and PFS (6.0 vs. 3.9, P = 0.045) were found in HLA-A heterozygous STS patients, while HLA-B homozygous patients showed better OS (36.4 vs. 87.2, P = 0.023). HLA-A heterozygous Mel patients showed lower PFS (8.3 vs. not reached, P = 0.013). Association rules analysis on HLA expression revealed 20 rules with high confidence, seven of which were associated with the survival. HLA-B*07 and HLA-C*07 (21.2 vs. 52.2), HLA-B*40 and HLA-C*03 (17.6 vs. 45.4), HLA-A*02 and HLA-B*07 and HLA-C*07 (16.8 vs. 47.0), HLA-A*02 and HLA-С*07 (17.6 vs. 41.1), HLA-B*40 and HLA-A*02 and HLA-C*03 (8.3 vs. 50.2) decreased OS in STS (P < 0.05). HLA-A*02 and HLA-B*07 and HLA-C*07 (3.2 vs. 6.0), HLA-B*40 and HLA-A*02 and HLA-C*03 (3.2 vs. 5.9) decreased PFS in STS patients (P < 0.05). HLA-B*35 and HLA-C*04 increased median OS in STS from 33.4 to 153.3 months.
Conclusions: HLA class I phenotype has a different impact on the survival in Mel and STS patients. The association rules based on HLA coexpression may have prognostic and predictive value. Further investigations of these parameters are warranted (The Trial Registration Number: NCT05539677).
Association of cough complaints with spirometry, nasal breathing in patients with asthma and allergic rhinitis
Authors: Khramova Regina N. , Krasilnikova Svetlana V. , Kolesnik Anna S. , Gorbunova Ksenia V. , Ovsyannikov Dmitry Yu. , Khramov Alexey A. , Shamrikova Anastasiia A. , Ignatov Georgii S. , Karpenko Maxim A. , Kubysheva Nailya I. , Khaletskaya Olga V. , Novikov Viktor V. , Bulgakova Vilya A. , Geppe Natalia A. , Eliseeva Tatyana I.
Published: February 2025

Aim: Cough is an important symptom of the combined course of bronchial asthma (BA) and allergic rhinitis (AR) and/or allergic rhinosinusitis (ARS), but the contribution of the pathology of the upper and lower airway to the formation of cough in these patients cannot be considered established. The aim of the study was to evaluate the relationship of cough intensity with indicators of external respiration and nasal respiratory function in children and adolescents with a combined course of BA and AR and/or ARS.
Methods: It was a single-center observational transverse pilot study. The absence and/or presence of cough and its intensity were scored in 122 patients (14.0 [11.0; 16.0] years) using the Sinonasal Outcome Test–22 (SNOT-22). Groups were identified: 1 (n = 29)—no cough (0 points), 2 (n = 72)—mild cough (1–2 points), 3 (n = 21)—moderate cough (3–4 points). Peak nasal inspiratory flow (PNIF) and spirometric parameters were measured.
Results: Assessment of cough by patients using the SNOT-22 test had negative correlations with spirometric indicators: z FEV1 and z FEV1/FVC (r = –0.23, P = 0.012, and r = –0.21 P = 0.023, respectively). A positive relationship was noted with changes in FEV1 in tests with bronchodilators (r = 0.43, P = 0.002) and with the severity of postnasal drip (r = 0.45, P < 0.001 and r = 0.43, P < 0.001, respectively).
Conclusions: Established correlations of cough intensity with spirometry indicators and with symptoms of postnasal drip in patients with combined BA and AR/ARS indicate the participation of both the upper and lower respiratory tract in the formation of cough.
2023. májusi összefoglaló
Authors: Vén Gergely
Published: February 2025

A Közbeszerzési Hatóság állásfoglalások formájában ad
felvilágosítást a közbeszerzési eljárásokban résztvevő
jogalkalmazók számára a közbeszerzési törvény és kapcsolódó végrehajtási rendeleteinek alkalmazásával
összefüggő általános jellegű megkeresésekre.
Alábbiakban a Kbt. alkalmazásával összefüggő kérdésekre adott válaszainkat rendeztük sorrendbe, bízva
abban, hogy iránymutatásaink nem csak a kérdésfeltevőknek, hanem valamennyi Olvasónknak hasznos információkkal szolgálnak.
Felhívjuk Tisztelt Olvasóink figyelmét, hogy a közbeszerzésekre irányadó jogszabályok alkalmazásával
kapcsolatos döntések meghozatala mindenkor a közbeszerzési eljárások résztvevőinek joga és felelőssége.
Hangsúlyozzuk továbbá, hogy az állásfoglalásokban
megfogalmazott véleményeknek jogi ereje, kötelező
tartalma nincsen.
D.6/26/2023. számú határozat
Authors: Horváth Éva
Published: February 2025

A Közbeszerzési Értesítő Plusz jelen számában ismertetett jogeset a dinamikus beszerzési rendszer létrehozására irányuló közbeszerzési eljárásban az alternatív
ajánlattétel, és a szakmai ajánlat kérdéskörökkel foglalkozik.
A Közbeszerzési Hatóság legfrissebb állásfoglalásai : 2023. augusztusi összefoglaló
Authors: Somogyi Klaudia Virág
Published: February 2025

A Közbeszerzési Hatóság állásfoglalások formájában ad felvilágosítást a közbeszerzési eljárásokban résztvevő jogalkalmazók számára a közbeszerzésekről szóló 2015. évi CXLIII. törvény (a továbbiakban: Kbt.) és kapcsolódó végrehajtási rendeleteinek alkalmazásával összefüggő általános jellegű megkeresésekre.
Az alábbiakban a Kbt. alkalmazásával összefüggő kérdésekre adott válaszainkat rendeztük sorrendbe, bízva abban, hogy iránymutatásaink nem csak a kérdésfeltevőknek, hanem valamennyi Olvasónknak hasznos információkkal szolgálnak.
Felhívjuk Tisztelt Olvasóink figyelmét, hogy a közbeszerzésekre irányadó jogszabályok alkalmazásával kapcsolatos döntések meghozatala mindenkor a közbeszerzési eljárások résztvevőinek joga és felelőssége. Hangsúlyozzuk továbbá, hogy az állásfoglalásokban megfogalmazott véleményeknek jogi ereje, kötelező tartalma nincsen.
Az ügyfélképesség a közbeszerzési jogorvoslati eljárásban : Hol húzódnak a kérelmezői beleszólásszabadság határai? (I. rész)
Authors: Pfeffer Zsolt
Published: February 2025

Az ügyfélképesség (actoratus realis) mint eljárási akadály kérdése a közbeszerzési jogorvoslati eljárásokban különleges hangsúlyt kap, hiszen ez a tételes jogban meg nem jelenő, ugyanakkor az elméletben, illetve a joggyakorlatban széles körben használt fogalom határolja be, hogy mely kérelmezők jogosultak kérelmet benyújtani a Közbeszerzési Döntőbizottsághoz. A jogorvoslati alapjogot korlátozza a jogalkotó az ügyfélképességre vonatkozó szabályok megalkotásakor, így az csak arányos és szükséges lehet. Az Európai Unió irányelvi szabályainak megfelelően kell kialakítani a tagállami előírásokat. A magyar közbeszerzési jog meglehetősen szűkszavú, a történeti tényállások rendkívül sokféleségére tekintettel óriási jelentősége van a vonatkozó joggyakorlatnak, valamint az általa kimunkált, ügyfélképességi elveknek nevezhető rendező megközelítéseknek. A tanulmány ezen elvek leírására, rendszerezésére és részletes bemutatására törekszik a joggyakorlat minél teljesebb körű feldolgozásával, a szükséges elméleti kitekintésekkel, valamint a vonatkozó feltevések megtételével.
Jogorvoslati aktualitások : A Döntőbizottság D.63/38/2024. számú határozata
Authors: Horváth Éva
Published: February 2025

A Közbeszerzési Értesítő Plusz jelen számában ismertetett jogeset az ajánlatkérőnek a közbeszerzés tárgyának gondos meghatározására vonatkozó kötelezettségével kapcsolatos. Az ajánlatkérő a közbeszerzési eljárás feltételrendszerében köteles megadni a közbeszerzés tárgyát, árubeszerzés esetén annak az árunak a leírását, amelynek megrendelése érdekében szerződést kíván kötni. A műszaki leírás azoknak az előírásoknak az összessége, amelyek meghatározzák a közbeszerzés tárgya tekintetében megkövetelt jellemzőket, amelyek alapján a közbeszerzés tárgya olyan módon írható le, hogy az megfeleljen az ajánlatkérő által igényelt rendeltetésnek. A jogorvoslati üggyel érintett tárgyak: A pontos beszerzési igény meghatározásának elmulasztása nem biztosítja az egyenlő esélyű, megfelelő ajánlattételt, amely indokolatlan versenykorlátozáshoz vezet.
A közszolgáltatási és egyéb tevékenységek kapcsolata az Európai Unió Bíróságának joggyakorlatában
Authors: Demendi Ágnes
Published: February 2025

A jelen szakcikk célja annak elemzése, hogyan ítéli meg az Európai Unió Bírósága azokat az eseteket, amelyekben a szerződés tárgya a közszolgáltatási tevékenységen kívüli egyéb szolgáltatás beszerzése. Jogesetek bemutatásán keresztül kerülnek vizsgálat alá azok a beszerzések, amelyek nincsenek közvetlen öszefüggésben a közszolgáltató ajánlatkérő fő profiljával, azaz az általa kötelezően ellátandó közszolgáltatással.
Interim Results of the De-Escalation of Adjuvant Radiotherapy in Patients with Early Breast Cancer Involving One to Three Axillary Lymph Nodes
Authors: Брянцева Жанна Викторовна , Акулова Ирина Александровна , Новиков Сергей Николаевич , Криворотько Петр Владимирович , Табагуа Тенгиз Тенгизович , Емельянов Александр Сергеевич , Горина Арина Олеговна , Яганова Татьяна Сергеевна , Ульрих Дарья Глебовна
Published: February 2025

Введение. Существуют разные точки зрения относительно целесообразности рутинного облучения над-подключичных лимфоузлов (НПЛУ) при проведении адъювантной лучевой терапии на зоны регионарного лимфооттока у пациенток с ранним раком молочной железы (РМЖ).
Цель. Изучить возможность безопасного отказа от облучения НПЛУ у больных ранним РМЖ с поражением 1–3 подмышечных лимфоузлов (ЛУ) или 1–2 сигнальных ЛУ и отсутствием дополнительных факторов риска.
Материалы и методы. В проспективное рандомизированное исследование за период с февраля 2022 по октябрь 2024 г. включена 121 больная ранним РМЖ. При принятии решения об объеме послеоперационной лучевой терапии все пациентки были разделены на две группы. В контрольной группе послеоперационная лучевая терапия проводилась в стандартном объеме — облучение оставшихся тканей молочной железы или мягких тканей передней грудной с подмышечными ЛУ I, II, III уровней и надключичными ЛУ; в исследуемой группе из объема облучения исключались подмышечные лимфоузлы III уровня и надключичные лимфоузлы.
Результаты. На момент проведения промежуточного анализа в исследование была включена 121 больная. У 52 женщин время наблюдения превысило 24 мес. В этой группе выполнен сравнительный анализ показателей локорегионарного контроля у 44 пациенток исследуемой группы (без облучения НПЛУ) и 8 больных контрольной группы, которым послеоперационная лучевая терапия проводилась в стандартном объеме. Двухлетняя выживаемость без признаков локорегионарного рецидива, в том числе в ипсилатеральной над-подключичной области, в обеих группах составила 100 %. Двухлетняя безрецидивная выживаемость составила 97,7 % в исследуемой группе и 100 % контрольной группе [p > 0,2]. У 1 пациентки в исследуемой группе установлена генерализация процесса с поражением костей.
Заключение. Деэскалация лучевой терапии у больных ранним РМЖ с поражением не более 3 подмышечных лимфоузлов в первые 2 года наблюдения не приводит к снижению показателей безрецидивной выживаемости и не увеличивает риск возникновения рецидива РМЖ в над-подключичной области.
Electrometric determination of cu (ii) cations, Zn (ii) and Cr (iii) in aqueous, water-non-aqueous and mixed solutions
Authors:   Candidate of Chemical Sciences, Associate Professor, Department of Medicinal and Biological Chemistry, Urgench branch of Tashkent Medical Academy, Urgench, Uzbekistan, Palvanov Narbek Sapaevich , Tillayeva Adolat Farkhadovna ,   Assistant, Department of Medicinal and Biological Chemistry, Urgench branch of Tashkent Medical Academy, Urgench, Uzbekistan
Published: February 2025

This work presents the results of the potentiometric determination of aqueous, non-aqueous and mixed solvents of copper (II), zinc (II) and chromium (III) cations: (propanol-2, acetone, methyl ethyl ketone, toluene, carbon tetrachloride, dimethylformamide) and their mixtures with water in a ratio of 1:1 and 1:19 by volume, the ratios of acid-base titrations are given. The quantitative results of the titration on a per kilote basis for the indicated cations Cu2+, Zn2+ and Cr3+ are based on the acidity constants of these cations assessed in the solvent environment specified above. The influence of the physical and chemical properties of solvents on acid-base titrations was studied. Due to the increase in the proportion of non-aqueous solvent in the solution, the dielectric constant of the solution decreases, and this leads to an increase in the ability to quantify acid-base titrations.
Principles and guidelines for developing students' intercultural communication competence
Authors:   Department of English Language Teaching Methodology, Namangan State Institute of Foreign Languages, Uzbekistan, Amanov Akmal
Published: February 2025

Currently, in the developed world, intercultural communication competence is of great importance for higher education students, enabling them to communicate effectively with representatives of different nationalities. Therefore, the development of students' intercultural communication competence is becoming a necessity of the time. This competence enables students to communicate effectively with representatives of different cultures, respect others' opinions, and accept diverse perspectives. This article highlights several principles: firstly, the principle of openness and tolerance, which allows students to learn about various cultures and develop a positive attitude towards them. Secondly, the principle of learning and exchanging experiences, fosters intercultural communication by facilitating the exchange of knowledge and experiences among students. The implementation of these principles and concepts serves as an effective tool for shaping intercultural communication competence, making a significant contribution to student’s personal and professional development.
Drivers and influencing mechanisms of agricultural carbon emissions in rural China: A systematic literature review and meta-analysis
Authors: Guo Zhen , Rashid Mohamad Fadhli
Published: February 2025

This research compares the findings of previous papers on agricultural carbon emission in rural China and analyzes the potential driving factors and influencing factors and mechanisms in a meta-analysis. In this paper, we also derive and elaborate on common economic, technological, policy, and social factors that affect agricultural carbon emissions based on a synthesis of published articles in refereed journals from 2000 to 2023. A total of 1,971 documents concerning agricultural carbon emissions in rural China were discovered using keyword searches in the Scopus and CNKI databases. The findings show a constant growth in research production, indicating rising worldwide interest in agricultural carbon emissions in China. We identify influential keywords, authors, and nations that shape the research landscape, emphasizing current worldwide collaboration networks and developing research hotspots. Citation networks highlight the importance of distributing scientific results, particularly significant papers from various years. The study examines the factors influencing agricultural carbon emissions in rural China, providing valuable insights for policymakers and researchers aiming to develop sustainable practices and manage climate change in agriculture.
A ACENTUAÇÃO GRÁFICA EXPLICADA POR REGRA ÚNICA: uma análise sobre a proposta apresentada pela Neopedagogia da Gramática
Authors: Silva Bruno Soares Tavares
Published: February 2025

Com o intuito de apresentar um debate acerca de uma forma mais simples e objetiva de abordar o tema da acentuação gráfica, tema este que grande parte da população brasileira sente dificuldade em aprender, não só por apresentar uma diversidade de regras, mas também por ser uma matéria pouco intuitiva. Este trabalho, então, analisará a tese 02 apresentada pelo professor Francisco Dequi, mentor do movimento Neodidático da Língua Portuguesa, no livro Neopedagogia da Gramática – 18 teses surpreendentes, e confrontará com os conceitos apresentados pelos professores Celso Cunha e Lindley Cintra, na Nova gramática do Português Contemporâneo, e os apresentados pelo professor Fernando Pestana, em A Gramática para Concursos Públicos. Como a matéria acentuação gráfica possui mais de 10 regras, algumas com algum grau de complexidade e outras com grande número de exceções, faz-se necessário ponderar se o conhecimento apresentado pela Neogramática abrange todos os casos apresentados pelos gramáticos tradicionais e se de fato facilita no aprendizado do tema.
REPRESENTAÇÕES E NARRATIVAS CINEMATOGRÁFICAS SOBRE O GENOCÍDIO EM RUANDA: UMA ANÁLISE COMPARATIVA
Authors: Magalhães Pablo Michel Candido Alves de
Published: February 2025

O artigo aqui apresentado visa desenvolver um estudo acerca das representações da realidade, a partir das apropriações desta por parte de diretores, nos discursos cinematográficos dos filmes Hotel Rwanda (2004) e Abril Sangrento (2005), que se propõe revisitar a história do genocídio de 1994, em Rwanda, país situado no centro do continente africano. Para tal, serão utilizados autores que versam sobre o evento, como Mamdani (2001) e Fonseca (2011), bem como pesquisadores que se debruçam sobre a reflexão discursiva em torno das obras cinematográficas, como Schurmans (2010) e Guzzo e Teixeira (2010).
Principais mecanismos de resistência em Staphylococcus epidermidis
Authors: Araújo Isaac Moura , Siqueira Marina Micaelle Rodrigues , Ferreira Maria Socorro , Mendes Keyciana Primo , Gonçalves Cicera Alane Coelho , Sousa Ângella Eduarda da Silva , Alves Daniel Sampaio , Borges Alex Sousa , Morais Luís Pereira de , Martins Anita Oliveira Brito Pereira Bezerra
Published: February 2025

Staphylococcus epidermidis é uma bactéria Gram-positiva, oportunista, e importante em infecções hospitalares, principalmente associadas a dispositivos médicos. Diferente de S. aureus, é coagulase-negativa e destaca-se pela formação de biofilmes em superfícies abióticas, contribuindo para sua persistência e resistência antimicrobiana. Suas adaptações incluem adesinas, cápsula extracelular, parede celular espessa e capacidade de sobreviver em ambientes hostis. Os mecanismos de resistência de S. epidermidis são variados e incluem a expressão do gene mecA, que codifica a proteína PBP2a, conferindo resistência a beta-lactâmicos. A resistência intermediária a glicopeptídeos, como vancomicina, ocorre pelo espessamento da parede celular. Mutações nos genes gyrA e grlA, além da ação de bombas de efluxo como NorA, contribuem para resistência a fluoroquinolonas. Resistência a macrolídeos, lincosamidas e estreptograminas é mediada pelo gene erm. A formação de biofilmes, compostos por polissacarídeos e proteínas, dificulta a ação de antibióticos e promove a troca de genes de resistência. O controle das infecções por S. epidermidis requer medidas multidisciplinares e rigorosas, incluindo controle de infecções hospitalares, manejo de dispositivos médicos e desenvolvimento de novas terapias. Sua resistência multifatorial e capacidade de formar biofilmes reforçam a urgência de soluções inovadoras para conter sua disseminação.
GAMIFICAÇÃO E SUSTENTABILIDADE: FERRAMENTAS LÚDICAS PARA A EDUCAÇÃO AMBIENTAL NO SÉCULO XXI
Authors: Vianna Pedro Henrique Farias , Santos Silvana Maria Aparecida Viana , Leite Gabriel Mateus Silva , Andrade Nubia Paulo de Costa , Costa Sheila Sousa da , Teixeira Haciane Moreira da Silva , Pereira Sara Yasmin Lima , Silva Reuber Araújo , Freitas Ana Paula da Costa , Silva Ivanildo Gomes da
Published: February 2025

Este artigo explora a interseção entre gamificação e sustentabilidade, destacando o potencial das ferramentas lúdicas na educação ambiental no século XXI. O problema central abordado é como a gamificação pode contribuir para o engajamento e a conscientização ambiental em contextos educacionais, enfrentando desafios como a desmotivação de estudantes e a complexidade dos temas ambientais. O objetivo do estudo é analisar criticamente a literatura acadêmica para identificar estratégias gamificadas eficazes na promoção de uma educação ambiental mais envolvente e transformadora. A pesquisa foi conduzida por meio de uma revisão de literatura qualitativa, com análise de 14 artigos publicados em revistas científicas, 1 artigo de evento e 1 livro, todos em língua portuguesa, publicados nos últimos 10 anos. As fontes foram obtidas no Google Acadêmico, e os dados foram organizados e interpretados para construir uma visão abrangente sobre o tema. Os resultados apontam que a gamificação pode transformar a aprendizagem ambiental, tornando-a mais interativa, prática e atraente. Elementos como recompensas, desafios e narrativas têm impacto positivo no engajamento e na retenção do conhecimento pelos estudantes. O estudo conclui que a gamificação é uma abordagem promissora para a educação ambiental, mas destaca a necessidade de capacitação docente e de mais pesquisas empíricas para validar sua eficácia em diferentes contextos.
Essential oils used as repellents against Aedes aegypti (Culicidae): a review of patent literature
Authors: Sousa Daniel Lobo , Junior Baraquizio Braga do Nascimento , Freitas Janaína Silva de
Published: February 2025

Due to the resistance of Aedes aegypti to the most common synthetic repellents, researches for alternative repellents have been made, for example, from essential oils. Given the need for more efficient repellents, the aim was to review the patent literature on the use of essential oils as repellents against Aedes aegypti. The review was carried out on the databases EPO, WIPO and on the Nacional Institute of Industrial Property-INPI. 77 patents were published, the first in 1992 and the last in 2023 with advances in formulations over the years. Most of the publications were from the United States, with 28 patents. 64 patents used essential oils as the main active principal. Of this total, the biggest was for topical use with 39 publications, being clove oil the most cited. The largest depositors were companies and universities from the United States and Brazil, respectively. Thus, the results demonstrated that patents related to repellents using essential oils against the Aedes aegypti mosquito have been published, but that repellents as an oviposition deterrent are incipient in the world.