bluuebunny/crossref_metadata_2025 huggingface dataset:
Prehospital Point-of-Care Ultrasound to Guide Life Saving Damage Control Interventions and Priority Transport in Resource Scarce Environments
Authors: Ryder Jessica A
Published: October 2024

Point-of-care ultrasound is a proven life-saving diagnostic tool that can be easily utilized in remote and austere settings with ever-improving portability. The utility of point-of-care ultrasound in prehospital care as a feasible and valuable tool to assist in prioritizing patients for damage control resuscitation and transport from the field will be highlighted with a focus on resource-limited environments and conflict settings. The session will conclude with a discussion around the successes, challenges, and lessons-learned after the implementation of a point-of-care ultrasound for trauma training program that was deployed to Ukraine in the fall of 2022.

Learning Objectives

Understand the role that point-of-care ultrasound can play in prehospital patient management.

Identify the benefits and pitfalls of point-of-care ultrasound utilization in the prehospital and resource-scarce environment.

Outline successful strategies and identify potential challenges for implementing a point-of-care ultrasound for trauma training program in complex environments.
What, how and when should I prototype? An empirical study of design team prototyping practices at the IDEA challenge hackathon
Authors: Ege Daniel Nygaard , Goudswaard Mark , Gopsill James , Steinert Martin , Hicks Ben
Published: October 2024

To improve understanding of prototyping practice at the fuzzy front end of the design process, this article presents an analysis of a prototyping dataset captured during the IDEA challenge – a 4-day virtually hosted hackathon – using Pro2booth, a web-based prototype capture tool. The dataset comprised 203 prototypes created by four independent teams working in university labs across Europe supported by interviews carried out with each of the teams after the event. The results of the study provide nine key findings about prototyping at hackathons. These include elucidation of the purposes of prototypes in physical, digital and sketch domains and characterisation of teams’ prototyping practices and strategies. The most successful strategy focused on learning about the problem or solution space, often via physical prototypes rather than following more prescriptive ‘theoretical’ methodologies. Recommendations on prototyping strategies in hackathons or similar scenarios are provided, highlighting the importance of practical strategies that prioritise learning and adaptation. The results of this study raise the broader question to the wider research community of how design research and teaching should balance high-level strategic approaches with more hands-on ‘operational’ prototyping.
Anonymisation, Pseudonymisation and Secure Processing Environments Relating to the Secondary Use of Electronic Health Data in the European Health Data Space (EHDS)
Authors: Rak Richard
Published: October 2024

By establishing a common data governance mechanism across the EU, the Regulation on the European Health Data Space (EHDS) aims to enhance the reuse of electronic health data for secondary use (e.g. public health, policy-making, scientific research) purposes and realise associated benefits. However, the EHDS requires health data holders to make available vast amount of personal and non-personal electronic health data, including electronic health data subject to intellectual property (IP) rights, for secondary use, which may pose risks for stakeholders (patients, healthcare providers and manufacturers alike). This paper highlights some conceptual legal problems which need to be addressed in order to provide clearer regulatory requirements to ensure effective and consistent implementation of key data minimisation measures (anonymisation or pseudonymisation) and data management safeguards (secure processing environments). The paper concludes that the EHDS has been drafted ambiguously (for example, its definition of “electronic health data” or the list of “minimum categories of electronic data for secondary use”), which could lead to inconsistent data management practices and may impair the rights and legitimate interests of data subjects and rights holders. To address legal uncertainties, prevent fragmentation and mitigate/eliminate risks, the EHDS requires closely coordinated implementation and legislative fine-tuning.
Fast monotonically integrated large eddy simulation solver: validation of a new scalable tool to study and optimize indoor ventilation
Authors: Leuenberger N.M. , Yang R. , Münzel L. , Verzicco R. , Lohse D. , Bourouiba L. , Jenny P.
Published: October 2024

Indoor ventilation is underutilized for the control of exposure to infectious pathogens. Occupancy restrictions during the pandemic showed the acute need to control detailed airflow patterns, particularly in heavily occupied spaces, such as lecture halls or offices, and not just to focus on air changes. Displacement ventilation is increasingly considered a viable energy efficient approach. However, control of airflow patterns from displacement ventilation requires us to understand them first. The challenge in doing so is that, on the one hand, detailed numerical simulations – such as direct numerical simulations (DNSs) – enable the most accurate assessment of the flow, but they are computationally prohibitively costly, thus impractical. On the other hand, large eddy simulations (LES) use parametrizations instead of explicitly capturing small-scale flow processes critical to capturing the inhomogeneous mixing and fluid–boundary interactions. Moreover, their use for generalizable insights requires extensive validation against experiments or already validated gold-standard DNSs. In this study, we start to address this challenge by employing efficient monotonically integrated LES (MILES) to simulate airflows in large-scale geometries and benchmark against relevant gold-standard DNSs. We discuss the validity and limitations of MILES. Via its application to a lecture hall, we showcase its emerging potential as an assessment tool for indoor air mixing heterogeneity.
Learning and semiautomatic intention labeling for classification models: a COVID-19 dialog attendance study for chatbots
Authors: dos Santos Júnior Valmir Oliveira , de Oliveira Marcos Antonio , Cruz Lívia Almada , Coelho da Silva Ticiana L.
Published: October 2024

It is increasingly common to use chatbots as an interface to services. One of the main components of a chatbot is the Natural Language Understanding (NLU) model, which is responsible for interpreting the text and extracting the intent and entities present in that text. It’s possible to focus only on one of these tasks of NLU, such as intent classification. To train an NLU intent classification model, it’s generally necessary to use a considerable amount of annotated data, where each sentence of the dataset receives a label indicating an intent. Performing manually labeling data is arduous and impracticable, depending on the data volume. Thus, an unsupervised machine learning technique, such as data clustering, could be applied to find and label patterns in the data. For this task, it is essential to have an effective vector embedding representation of texts that depicts the semantic information and helps the machine understand the context, intent, and other nuances of the entire text. This paper extensively evaluates different text embedding models for clustering and labeling. We also apply some operations to improve the dataset’s quality, such as removing sentences and establishing various strategies for distance thresholds (cosine similarity) for the clusters’ centroids. Then, we trained some intent classification Models with two different architectures, one built with the Rasa framework and the other with a neural network (NN) using the attendance text from the Coronavirus Platform Service of Ceará, Brazil. We also manually annotated a dataset to be used as validation data. We conducted a study on semiautomatic labeling, implemented through clustering and visual inspection, which introduced some labeling errors to the intent classification models. However, it would be unfeasible to annotate the entire dataset manually. Nevertheless, results of competitive accuracy were still achieved with the trained models.
Discrimination Against Puerto Ricans in the Puerto Rican Housing Market: Evidence From a Preregistered Audit Experiment
Authors: Castro Irizarry Giovanni
Published: October 2024

Do locals discriminate against themselves by favoring foreigners with higher expected purchasing power? Drawing on theories of prejudice, discrimination, and colonialism, I argue that in colonized and post-colonial countries, local home sellers discriminate against local potential homebuyers while favoring foreigners with expected higher purchasing power, anticipating a more profitable transaction. I support this argument with evidence from a preregistered online audit study targeting discriminatory attitudes toward local home buyers. In the study, fictitious home buyers with distinctive language and ethnic names emailed 1,512 home sellers (realtors and homeowners) across all municipalities in Puerto Rico. Home sellers reported more houses available to Americans and invited them to more house showings than Puerto Ricans. My estimates indicate that ethnic discrimination exists in the Puerto Rican housing market. These findings provide new insights into ethnic dynamics in colonized and post-colonial societies and underscore concerns about recent legislation that turned Puerto Rico into a tax haven.
BOOKS KEPT AT THE SHRINE OF EDWARD THE CONFESSOR AT WESTMINSTER ABBEY IN THE LATE MIDDLE AGES
Authors: Payne Matthew
Published: October 2024

Three late medieval inventories of the chapel surrounding the shrine of St Edward the Confessor at Westminster Abbey, London, record the presence of a number of books and pamphlets among the relics and liturgical paraphernalia. This article discusses these books, their significance and the reason for their maintenance at the shrine, and offers possible identifications with several surviving manuscripts.
Combined association between dietary antioxidant quality score and leisure-time physical activity on sleep pattern in cancer survivors: a cross-sectional study of National Health and Nutrition Examination Surveys database
Authors: Yu Rong , Lin Xiaonv , Peng Fanyu , Liu Chunli , Ning Yun , Wu Suya , Shen Siwen , Zhang Liuliu , He Xia
Published: October 2024

This study aimed to explore the combined association between the dietary antioxidant quality score (DAQS) and leisure-time physical activity on sleep patterns in cancer survivors. Data of cancer survivors were extracted from the National Health and Nutrition Examination Surveys database in 2007–2014 in this cross-sectional study. Weighted multivariable logistic regression models were used to estimate OR and 95 % CI for the association of DAQS and leisure-time physical activity on sleep patterns. The combined association was also assessed in subgroups of participants based on age and use of painkillers and antidepressants. Among the eligible participants, 1133 had unhealthy sleep patterns. After adjusting for covariates, compared with low DAQS level combined with leisure-time physical activity level < 600 MET·min/week, high DAQS level combined with leisure-time physical activity ≥ 600 MET·min/week was associated with lower odds of unhealthy sleep patterns (OR = 0·41, 95 % CI: 0·23, 0·72). Additionally, the association of high DAQS level combined with high leisure-time physical activity with low odds of unhealthy sleep patterns was also significant in < 65 years old (OR = 0·30, 95 % CI: 0·13, 0·70), non-painkiller (OR = 0·39, 95 % CI: 0·22, 0·71), non-antidepressant (OR = 0·49, 95 % CI: 0·26, 0·91) and antidepressant (OR = 0·11, 95 % CI: 0·02, 0·50) subgroups. DAQS and leisure-time physical activity had a combined association on sleep patterns in cancer survivors. However, the causal associations of dietary nutrient intake and physical activity with sleep patterns in cancer survivors need further clarification.
Jewish-Muslim Friendship Networks: A Study of Intergenerational Boundary Work in Postwar Germany
Authors: Emmerich Arndt
Published: October 2024

This article presents a little-known story of Jewish-Muslim coexistence in Germany after World War Two. Using an ethnographic case study of Frankfurt am Main’s train-station district (Bahnhofsviertel), the analysis investigates long-term and partially forgotten Jewish-Muslim narratives, relations, and neighborhood encounters, paying particular attention to the changing political, spatial, and temporal dimensions that have blurred or closed symbolic boundaries between Jews and Muslims since the late 1960s. Bringing together the scholarship on symbolic boundaries and urban diversity, the theoretical discussion contributes to a more nuanced understanding of the variegated processes of Jewish-Muslim boundary-making and un-making over time, as well as the macro- and micro-level influences which shape these negotiations and outcomes. Studying Jewish-Muslim relations at the neighborhood level by adopting a boundary-related approach brings out more clearly the tensions over groupism and fluidity in theoretical debates and removes the current exceptionalism around Jewish-Muslim themes, making them more easily compared with other boundary processes within everyday life.
State Formation and Bureaucratization: Evidence from Pre-Imperial China
Authors: Chen Joy
Published: October 2024

This paper studies the relationship between military conflicts and state-building in pre-imperial China. I develop an incomplete contract model to examine rulers’ and local administrators’ incentives in conflict. Defensive wars drive decentralization: landowning local administrators have more to gain from a successful defense and are therefore more committed to it. Offensive wars drive centralization: the landowning ruler has personnel control over the non-land-owning local administrator and can therefore force the latter to participate in less lucrative attacks. Model predictions are corroborated with empirical evidence and historical case studies, and offer broader implications for the political divergence between China and Europe.
The Great Depression as a Savings Glut
Authors: Degorce Victor , Monnet Eric
Published: October 2024

New data covering 23 countries reveal that banking crises of the Great Depression coincided with a sharp international increase in deposits at savings institutions and life insurance. Deposits fled from commercial banks to alternative forms of savings. This fueled a credit crunch since other institutions did not replace bank lending. While asset prices fell, savings held in savings institutions and life insurance companies increased as a share of GDP and in real terms. These findings provide new explanations for the fall in credit and aggregate demand in the 1930s. They illustrate the need to consider nonbank financial institutions when studying banking crises.
Experimental study on the formation and evolution of unconfined counter-helicity spheromaks merging using magnetized coaxial plasma gun
Authors: Qi Liangwen , Song Jian , Zhao Fantao , Yu Siqi , Zhao Chongxiao , Yan Huijie , Wang Dezhen
Published: October 2024

The formation and evolution of unconfined counter-helicity spheromaks merging have been experimentally investigated by using a magnetized coaxial plasma gun. By comparing the time-dependent photodiode signals and plasma radiation images of counter-helicity spheromaks merging and plasma jets merging, it is found that the field-reversed configuration (FRC) plasma formed by counter-helicity spheromaks merging has a distinct contour and a long maintenance time. For plasma jets merging, the resulting plasma has no discernible contours and a shorter lifetime. In addition, it is inferred from these data that stagnation heating and magnetic reconnection events occur during the counter-helicity spheromaks merging, causing a rapid rise in plasma pressure at the merging midplane and sharp kinks in the field lines near the merger region. By changing different operating parameters and observing the impact on the merger characteristics, it is suggested that the qualitative dynamics of the FRC plasma depends on the balance between the plasma pressure and the magnetic pressure. The high discharge voltage breaks the equilibrium in the merged body, while the large gas-puffed mass just weakens the compression effect of the merged body. These results give us an intuitive understanding of the counter-helicity spheromak merger process and its dependence on discharge parameters, and also provide a distinct perspective for the optimal design of FRC.
Assessment of farmers' knowledge, attitudes and control practices (KAP) to mitigate acaricide resistance and tick-borne diseases
Authors: Jamra Sunita , Shakya Mukesh , Jayraw Anant K. , Agrawal Vivek , Singh Mamta , Sharma Anil Kumar , Bhangale Gajendra N. , Jatav Gaya P. , Jamra Nirmala
Published: October 2024

A knowledge, attitudes and control practices (KAP)-based study on ticks and tick-borne diseases (TTBD) and resistance development in ticks was conducted in Dhar district of Madhya Pradesh covering 200 livestock owners using a questionnaire. Based on our scoring criteria, results indicated only 25% (19.16–31.60) respondents possessing basic knowledge of TTBDs while 75% (68.40–80.84) respondents were not aware of TBDs. Due to lack of proper awareness of TTBDs, about 1.28 times more respondents (OR 95% CI 0.42–3.86) were having heavy tick infestations in their animals. However, about 36.5% (29.82–43.58) respondents showed a favourable attitude towards the adoption of different tick control practices; consequently, their animals showed low-level infestation. Amongst various feeding systems for animals, a mixed type of feeding system was mostly adopted by 57.5% respondents followed by manger system (37.5%) while grazing was the least adopted method (5%). Results indicated that the grazing animals were 6 times (OR 95% CI 2.93–12.28) more susceptible to ticks and possessed heavy tick infestation. Resistance status of collected tick isolates of Rhipicephalus microplus and Hyalomma anatolicum was assessed and revealed that both tick species were found resistant to deltamethrin. The goals of this study were to assess some of the underlying causes of ticks and TBD in livestock in Dhar district of Madhya Pradesh state using the KAP survey and resistance characterization of ticks.
Twice-occurring terms in Herodotus: random distribution, habit of presentation and deliberate pairings
Authors: Dillery John
Published: October 2024

Repetition is a critical issue in interpreting the work of Herodotus. Detlev Fehling, for one, has pointed to recurrence of motif and scene as evidence of the historian’s ‘free invention’. Words that occur twice in Herodotus are an efficient way to consider pressing issues at the centre of how and why Herodotus put together his narrative in the way he has. Pairs where the uses are close together in stories with a lot in common suggest that we may be seeing Herodotus’ ‘habit of presentation’, especially when phrasal repetition is also found. Where pairs are found further apart, the issue of deliberate linkage between discrete episodes may be indicated through the strategic redeployment of a key term. Finally, with Xerxes’ invasion, recurring terms help us to see how Herodotus could operate over large portions of text, deliberately linking one episode to another through the deployment of twice-occurring words, thereby also connecting the whole account of the campaign to the largest project of the History.
The Athenian Empire and epigraphic cultures
Authors: Lazar Leah
Published: October 2024

This article revisits the question of how the epigraphic culture of the fifth-century BC Athenian Empire impacted on the epigraphic cultures of other communities. Through consideration of the late fifth-century epigraphic cultures of Thasos and Rhodes, it argues that allied communities interacted with the epigraphic manifestations of Athenian authority in different ways, producing diverse epigraphic responses. Further, it argues that the first traces of the shift from the heterogeneity of archaic epigraphic cultures to the epigraphic convergence of the late classical world can be found in the tension between local and Athenian influences in late fifth-century public inscription beyond Athens.
Integrated orbit determination and time synchronization using inter-satellite observations for BDS-3 satellites with satellite clock drifts estimated simultaneously
Authors: Ruan Rengui
Published: October 2024

By simultaneously estimating satellite clock drifts (SCDs) as either constant parameters or piece-wise parameters, we present an improved integrated orbit determination and time synchronization approach for BDS-3 satellites with raw inter-satellite link (ISL) observations. Experiments with L-band data from seven monitoring stations in China and ISL data from eight satellites of the third-generation Beidou Navigation Satellite System (BDS-3) were carried out and the two SCD estimation strategies are validated. It is demonstrated that, with SCDs estimated, the quality of orbits and clock offsets is comparable to those with SCDs corrected using predicted values. The accuracy of the estimated orbits and clocks are up to 0.019 m (radial) and 0.095 ns, respectively, with improvements of 95% and 90%, when compared with the results using the L-band data alone. It is also demonstrated that estimating SCDs time slice by time slice is slightly worse in accuracy but superior in coping with possible frequency jump of satellite clocks.
The Changing Substance of European Law
Authors: Dawson Mark
Published: October 2024

Intrinsic relation between form and substance in law and between the institutional law of the EU and its substantive goals – idea and criteria for a ‘substantive core’ to the legal order – the internal market as early EU law’s substantive core – the EU’s changing policy substance and the subsequent ‘de-coring’ of the legal order – the consequences of de-coring and its impact on EU law’s relevance and legitimacy – early attempts to reconcile EU law with the changing substance of EU policy.
The Problem of the University
Authors: Yeomans S. Walter
Published: October 2024

Love of learning, or learning itself? Culture, or the acquisition of specialized knowledge? This is the great problem which faces every university in the modern age. Some, indeed, claim to have solved it to their own satisfaction. Others are still grappling with it.

The problem has been created by the passage of time and the opening up of fresh fields of thought and knowledge. Applying equally to both the old and the new worlds, it is of universal importance, inasmuch that on the solution of it depends the future, not merely of our educational systems, but of our civilization itself.

The university was essentially an invention of the Middle Ages, existing for one definite purpose. First and foremost it was a cultural institution; the acquisition of mere knowledge, as such, was of secondary and almost negligible importance.
School and Stage
Authors: Pepler Hilary
Published: October 2024

In the programme of “The Field is Won,” the play recently performed in honour of our new English Saints, the mime is referred to as “a means of education.” Although the phrase was inserted to appease the taxer of entertainments (thus saving many pounds to the producer) it is also true if, by education, we mean the drawing out of what is there and not the hammering in of what is not already present in the child’s being. Mime is the art of sign language, a language which existed even before the Tower of Babel and must last as long as man has the power of movement and sense of sight. It is used by Almighty God and is the daily language of His Church. It is also the daily language of policemen, publicans, soldiers, schoolmasters and others who command or serve.
The origin and contested meaning of freedom in the human right to science
Authors: Kinzelbach Katrin
Published: October 2024

This article traces how the ‘freedom indispensable for scientific research’ was introduced into the International Covenant on Economic, Social and Cultural Rights (ICESCR). The review of the drafting history covers ICESCR Article 15.3 and that of its precursor, Article 27 in the Universal Declaration of Human Rights (UDHR). It pays particular attention to arguments presented during negotiations over the UDHR (adopted in 1948), as well as over the ICESCR (adopted in 1966), and it reflects on observable norm entrepreneurship. Following the end of the Cold War, details on the right to science and the status of higher education personnel were further elaborated in soft law, notably in the form of two General Comments and two UNESCO Recommendations. These specifications and the earlier traveaux préparatoires reveal a multifaceted and rich debate about science, development, dignity and freedom at the United Nations, including positions that span variations of a liberal science script as well as persistent illiberal contestations.
Content Moderator Coping Strategies
Authors: Spence Ruth , Martellozzo Elena , DeMarco Jeffrey
Published: October 2024

Abstract: Content moderators (CMs) apply policies set by platforms to protect users from harmful content. It is a stressful job, associated with reduced mental health and well-being. In this study, an anonymous survey was used to demonstrate most CMs cope by seeking support from colleagues and this is associated with lower psychological distress and secondary trauma and higher well-being whereas increased smoking and alcohol consumption is associated with increased symptomology. Well-being services were not related to a reduction in psychological distress or trauma. We argue these results fit within a framework of trauma-informed working and provide evidence for its utility in the trust and safety sector. They also highlight the need for continued research into “what works” to support the resilience of frontline staff.
Transliminality – Converging Evidence of Associations With and Openness to Experience and Its Facets
Authors: Swami Viren , Pietschnig Jakob , Stieger Stefan , Voracek Martin , Tran Ulrich S.
Published: October 2024

Abstract: Transliminality refers to permeable mental boundaries that entail a susceptibility to, and awareness of, material from unconscious sources and the external environment. Here, we examined the extent to which transliminality is associated with the personality trait of Openness to Experience. Three samples of visitors to art galleries (total N = 770) completed measures of transliminality and Openness. Initial analyses suggested that the construct of transliminality was multidimensional, consisting of mild absorption-like experiences and more disintegrative-like experiences, respectively. Transliminality, at both manifest and latent levels, was significantly, positively, and with medium to large effect sizes associated with higher-order Openness. However, this correspondence was primarily driven by associations with three lower-order Openness facets (Fantasy, Aesthetics, and Values). These associations were replicable across all three samples and robust after accounting for participant sociodemographic variables. These convergent, internally replicating findings suggest that transliminality may lie at the end of a continuum of experiential openness.
The HEXACO–Disintegration (HEXACOD) Personality Model in Early and Late Adolescence
Authors: Lazarević Ljiljana B. , Pfattheicher Stefan , Krstić Ksenija , Ścigała Karolina Aleksandra , Knežević Goran
Published: October 2024

Abstract: This study investigated the robustness of the seven-factor HEXACO–Disintegration (HEXACOD) personality model in children and adolescents, across three age groups (10–13, 14–15, and 16–18 years). Using exploratory structural equation modeling (ESEM), we assessed the invariance of the proposed seven-factor model. The results supported the HEXACOD model's metric invariance across age groups. The Disintegration factor lay outside the HEXACO traits, corroborating the claim that the HEXACO model does not capture a wide range of psychotic-like experiences and behaviors (PLEBs). Moderated nonlinear factor analysis (MNLFA) also showed stability of the HEXACOD model across ages. Furthermore, the results show that Disintegration presents a trait-like disposition on the same level of coherence and robustness as HEXACO traits even in children and adolescents.
Reciprocal Relationships Between Coping Strategies and Well-Being in Children and Adolescents
Authors: Groß Daniel , Schröder Ines , Wasserfall Nicola , Eschenbeck Heike , Kohlmann Carl-Walter
Published: October 2024

Abstract: Background: Not much is known about reciprocal prospective within-person effects between various coping strategies or between coping strategies and well-being in minors. Aims: Therefore, we used a random intercept cross-lagged panel model (RI-CLPM) with four-time points spaced 6 months apart to analyze how five coping strategies (seeking social support, problem-solving, avoidant coping, palliative emotion regulation, anger-related emotion regulation) were associated with each other and with well-being. Method: The sample comprised 702 minors. Their age at Time 1 was 10.30 years ( SD = 1.35; range: 8–14). Results: On the between-person level, problem-solving and palliative emotion regulation were positively related to well-being, whereas anger-related emotion regulation was negatively related. Among the coping strategies themselves, anger-related emotion regulation and problem-solving were positively correlated with seeking social support, and problem-solving and seeking social support were negatively correlated with avoidant coping. At the within-person level, avoidant coping was negative, and seeking social support was positively bidirectionally associated with well-being. Additionally, well-being positively influenced problem-solving, and seeking social support was positively and avoidant coping was negatively bidirectionally associated with problem-solving. Limitations: Due to the 6-month interval, statements are limited to only this time period. Furthermore, whereas we controlled for time-invariant covariates, we did not control for time-varying covariates. Conclusion: The findings underscore the importance of simultaneously examining different coping strategies along with well-being in a within-person design. Understanding the links between coping and well-being can contribute to the development and use of interventions promoting minors’ coping and well-being.
A Simple and Robust CryoSat‐2 Radar Freeboard Correction Method Dedicated to TFMRA50 for the Arctic Winter Snow Depth and Sea Ice Thickness Retrieval
Authors: Shi Hoyeon , Tonboe Rasmus , Lee Sang‐Moo , Dybkjær Gorm , Sohn Byung‐Ju , Singha Suman , Baordo Fabrizio
Published: October 2024

CryoSat‐2 has been successful in observing sea ice thickness from space by providing ice freeboard information. The initial estimate of the ice freeboard, called radar freeboard, is obtained by analyzing the observed waveform using a retracker. A series of corrections are needed to convert the radar freeboard to the ice freeboard. Those are the physical effects (e.g., changes in wave propagation speed and the distribution of scattering at snow and ice surfaces, etc.) and the bias of the retracker; however, traditionally, only the wave speed correction has been applied due to lack of enough information to perform the complete correction. Here, an alternative correction method for the CryoSat‐2 radar freeboard derived using the Threshold First‐Maximum Retracker Algorithm with a 50% threshold (TFMRA50) is proposed. Snow depth was used as a predictor for the correction, similar to the traditional wave speed correction, but the coefficients were empirically determined by performing a direct comparison of the radar freeboard from CryoSat‐2 and the ice freeboard from airborne observations. Consequently, this new empirical correction treats the physical effects and the retracker bias as a whole, which have been difficult to separate in the retrieval process. In this paper, we demonstrate that the retrieval accuracy of snow and ice variables and the consistency of the two independent retrieval methods are improved when the new correction is applied. The result of this study emphasizes the importance of compatibility between the retracker and the freeboard correction method.
Intercropping Legumes Improves Long Term Productivity and Soil Carbon and Nitrogen Stocks in Sub‐Saharan Africa
Authors: Fuchs Kathrin , Kraus David , Houska Tobias , Kermah Michael , Haas Edwin , Kiese Ralf , Butterbach‐Bahl Klaus , Scheer Clemens
Published: October 2024

Food, feed, and fiber production needs to increase to support demands of the growing population in Sub‐Saharan Africa (SSA), while soil fertility continues to decline. Intercropping, the cultivation of two or more crop species on the same field, can provide yield benefits and is suggested to positively affect soil organic carbon (C) and nitrogen (N) stocks. This study uses the biogeochemical model system LandscapeDNDC with the objective to (a) represent maize‐legume intercropping systems in different bioregions in SSA by simultaneously simulating both crops and their interactions and (b) assess long‐term (20 years) impacts of intercropping under varying mineral fertilizer inputs (0–150 kg N ha−1 yr−1) on productivity as well as soil organic C and N stocks. We test LandscapeDNDC on 82 field data sets (site‐year‐treatment combinations) from 18 sites to represent yields and soil C/N dynamics of maize‐legume intercropping systems. Using the model for long‐term scenario simulations showed that intercropping allows to sustain productivity and to improve or maintain SOC stock in low or zero fertilizer systems if all residues are returned to the soil. In contrast, for sole‐cropped maize systems, a decline in SOC stocks was simulated unless a minimum of 35 kg N ha−1 yr−1 of fertilizer was applied at full residue return. We conclude that intercropping using legumes alongside sufficient residue return allows for stabilizing long‐term yields while avoiding SOC losses even with low fertilizer N inputs. Overall, our study confirms the potential of intercropping as a sustainable agricultural practice that could significantly contribute to food security in SSA.
Spatial and Seasonal Controls on Eddy Subduction in the Southern Ocean
Authors: Chen Michael L. , Schofield Oscar
Published: October 2024

Carbon export driven by submesoscale, eddy‐associated vertical velocities (“eddy subduction”), and particularly its seasonality, remains understudied, leaving a gap in our understanding of ocean carbon sequestration. Here, we assess mechanisms controlling eddy subduction's spatial and seasonal patterns using 15 years of observations from BGC‐Argo floats in the Southern Ocean. We identify signatures of eddy subduction as subsurface anomalies in temperature‐salinity and oxygen. The anomalies are spatially concentrated near weakly stratified areas and regions with strong lateral buoyancy gradients diagnosed from satellite altimetry, particularly in the Antarctic Circumpolar Current's standing meanders. We use bio‐optical ratios, specifically the chlorophyll a to particulate backscatter ratio (Chl/bbp) to find that eddy subduction is most active in the spring and early summer, with freshly exported material associated with seasonally weak vertical stratification and increasing surface biomass. Climate change is increasing ocean stratification globally, which may weaken eddy subduction's carbon export potential.
Particle Concentrations and Sizes for the Onset of Settling‐Driven Gravitational Instabilities: Experimental Validation and Application to Volcanic Ash Clouds
Authors: Fries Allan , Lemus Jonathan , Jarvis Paul A. , Clarke Amanda B. , Phillips Jeremy C. , Manzella Irene , Bonadonna Costanza
Published: October 2024

Settling‐driven gravitational instabilities (SDGIs) can form at the base of buoyant particle‐laden suspensions, modulating particle sedimentation in various settings such as meteorological and volcanic clouds, fluvial plumes, magma chambers, submarine hydrothermal plumes, or industrial emissions. These instabilities result in the formation of rapidly descending currents called ‘fingers’ within which fine particles settle faster collectively than individually. This study investigates SDGI triggering conditions underneath volcanic ash clouds through analogue experiments considering sedimentation from aqueous particle suspensions. We confirm that the conditions for which SDGIs develop are controlled by two dimensionless numbers: Bf (ratio of the characteristic finger velocity to the individual particle settling velocity); and Bi (ratio of timescale for individual particle settling to that for collective settling controlled by inertial drag). SDGIs are triggered for values of Bf and Bi > 1 for which particles are fully coupled with the flow within fingers. Using these parameters, we produce a regime diagram for the 2010 eruption of Eyjafjallajökull (Iceland) that describes particle settling as a function of particle concentration and size. More studies are needed to produce a general regime diagram accounting for the evolution of SDGIs properties with eruption and atmospheric parameters. Nonetheless, our study confirms that fingers affect sedimentation from volcanic clouds with high ash volume fractions above 10−6 vol.%. Our validation of criteria predicting the onset of fingers due to SDGIs constitutes a step forward toward the incorporation of these collective settling processes in volcanic ash transport and dispersion models.
Widespread D″ ${\mathbf{D}}^{\mathbf{{\prime\prime}}}$ Anisotropy Beneath North America and the Northeastern Pacific and Implications for Upper Mantle Anisotropy Measurements
Authors: Wolf Jonathan , Frost Daniel A. , Brewster Alexia , Long Maureen D. , Garnero Ed , West John D.
Published: October 2024

Observations of seismic waves that have passed through the Earth's lowermost mantle provide insight into deep mantle structure and dynamics, often on relatively small spatial scales. Here we use SKS, S2KS, S3KS, and PKS signals recorded across a large region including the United States, Mexico, and Central America to study the deepest mantle beneath large swaths of North America and the northeastern Pacific Ocean. These phases are enhanced via beamforming and then used to investigate polarization‐ and propagation direction‐dependent shear wave speeds (seismic anisotropy). A differential splitting approach enables us to robustly identify contributions from anisotropy. Our results show strong seismic anisotropy in approximately half of our study region, indicating that anisotropy may be more prevalent than commonly thought. In some regions, the anisotropy may be induced by flow driven by sinking cold slabs, and in other, more compact regions, by upwelling flow. Measured splitting due to lowermost mantle anisotropy is sufficiently strong to be non‐negligible in interpretations of SKS splitting due to upper mantle anisotropy in certain regions, which may prompt future re‐evaluations of upper mantle anisotropy beneath North and Central America.
The Observed Spatiotemporal Variability of Antarctic Winter Water
Authors: Spira T. , Swart S. , Giddy I. , du Plessis M.
Published: October 2024

The Southern Ocean (SO) is central to the global overturning circulation. South of the Antarctic Polar Front, Antarctic Winter Water (WW) forms in the wintertime mixed layer (ML) and becomes a subsurface layer following summertime restratification of the ML, overlaying upwelled deep waters. Model simulations show that WW acts as a conduit to seasonally transform upwelled deep waters into intermediate waters. Yet, there remains little observational evidence of the distribution and seasonal characteristics of WW. Using 18 years of in situ observations, we show seasonal climatologies of WW thickness, depth, core temperature, and salinity, revealing a distinct regionality and seasonality of WW. The seasonal cycle of WW characteristics is tied to the annual sea ice evolution, whereas the spatial distribution is impacted by the main topographic features in the SO driving an equatorward flux of WW. Through the identification of these localized northward export regions of WW, this study provides further evidence suggesting an alternative view from the conventional “zonal mean” perspective of the overturning circulation. We show that specific overturning pathways connecting the subpolar ocean to the global ocean can be explained by ocean‐topography interactions.
Large Scale Oscillations in the Martian Tropical Cloud Belt
Authors: Wang Huiqun , Richardson Mark I. , Toigo Anthony D. , Newman Claire E.
Published: October 2024

The Tropical Cloud Oscillation (TCO) in the Martian atmosphere is a shift of clouds in the northern spring and summer tropical cloud belt between the eastern and western hemispheres on an intra‐seasonal timescale of about 10–40 sols. The TCO is a significant intraseasonal variation and may strongly affect the Martian general circulation, water cycle, and dust cycle. We examine TCOs using multiple data sets with a focus on the clouds observed in Mars Daily Global Maps during Mars Year (MY) 29–35. One or more TCO cycles are observed in each MY and the phenomenon is most prominent during Ls = 135°–185°. Space‐time spectral analysis shows a variety of waves which appear to follow the theoretical dispersion relationships of equatorial waves, such as Kelvin waves, Rossby waves, and Mixed Rossby Gravity waves. The TCO appears to be controlled by zonal wavenumber one traveling waves with Kelvin and Rossby wave characteristics and exhibits a fine‐scale latitudinal structure that requires modeling with sufficient resolution. Issues with current data assimilation products for use in studies of Martian equatorial waves due to this fine‐scale structure are discussed.
Basalt Alteration in a CO2–SO2 Atmosphere: Implications for Surface Processes on Venus
Authors: Reid Robert B. , McCanta Molly C. , Filiberto Justin , Treiman Allan H. , Keller Lindsay , Rutherford Malcolm
Published: October 2024

Venus' surface and interior dynamics remain largely unconstrained, due in great part to the major obstacles to exploration imposed by its 470°C, 90 bar surface conditions and its thick, opaque atmosphere. Flyby and orbiter‐based thermal emission data provide opportunities to characterize the surface composition of Venus. However, robust interpretations of such data depend on understanding interactions between the planet's surface basaltic rocks and its caustic carbon dioxide (CO2)‐dominant atmosphere, containing trace amounts of sulfur dioxide (SO2). Several studies, using remote sensing, thermodynamic modeling, and laboratory experiments, have placed constraints on basaltic alteration mineralogy and rates. However, constraints on the effects of SO2‐bearing reactions on basalts with diverse compositions remain incomplete. Here, we present new data from a series of gas‐solid reaction experiments, in which samples of two basalt compositions were reacted in an SO2‐bearing CO2 atmosphere, at relevant Venus temperatures, pressure, and oxygen fugacity. Reacted specimens were analyzed by scanning electron microscopy and scanning transmission electron microscopy using sample cross‐sections produced with focused ion beam milling. Surface alteration products were characterized, and their abundances estimated; subsurface cation concentrations were mapped to show the depth of alteration. We demonstrate that the initial development of reaction products progresses rapidly over the course of 30‐day runs. Alkaline basalt samples are coated by Na‐sulfate (likely thenardite, Na2SO4) and amorphous calcium carbonate (CaCO3) alteration products, and tholeiitic basalt samples are primarily covered by anhydrite (CaSO4), Fe‐oxide (FexOy: likely magnetite, Fe3O4), and other minor phases. These mineralogies differ from previous experiments in CO2‐only atmospheres.
The oncogenic axis YAP/MYC/EZH2 impairs PTEN tumor suppression activity enhancing lung tumorigenicity
Authors: Lo Sardo Federica , Turco Chiara , Messina Beatrice , Sacconi Andrea , Auciello Francesca Romana , Pulito Claudio , Strano Sabrina , Lev Sima , Blandino Giovanni
Published: October 2024

The tumor suppressor PTEN (phosphatase and tensin homolog deleted in chromosome 10) is genetically deleted or downregulated in many cancer types. Loss of PTEN protein expression is frequently found in lung cancer while genetic alterations are less abundant. PTEN expression is regulated at multiple genetic and epigenetic levels and even partial reduction of its expression increases cancer occurrence. We show that YAP and TAZ cooperate with EZH2, and MYC to transcriptionally repress onco-suppressor genes, including PTEN, in non-small cell lung cancer (NSCLC) cells. YAP/TAZ-EZH2-MYC transcriptional regulators form a nuclear complex that represses PTEN transcription, while their combinatorial targeting restores PTEN expression, attenuates NSCLC cell growth, and prevents compensatory responses induced by single treatments. Datasets analysis of NSCLC patients revealed that PTEN expression is negatively correlated to YAP/TAZ, EZH2 and MYC and that low expression of PTEN is predictive of poor prognosis, especially at earlier stages of the disease. These findings highlight the repressive role of the YAP/TAZ-EZH2-MYC axis on tumor-suppressor genes and offer a potential therapeutic strategy for lung cancer patients with low PTEN levels.
Suppressive cancer nonstop extension mutations increase C-terminal hydrophobicity and disrupt evolutionarily conserved amino acid patterns
Authors: Ghosh Avantika , Riester Marisa , Pal Jagriti , Lainde Kadri-Ann , Tangermann Carla , Wanninger Angela , Dueren Ursula K. , Dhamija Sonam , Diederichs Sven
Published: October 2024

Nonstop extension mutations, a.k.a. stop-lost or stop-loss mutations, convert a stop codon into a sense codon resulting in translation into the 3’ untranslated region until the next in-frame stop codon, thereby extending the C-terminus of a protein. In cancer, only nonstop mutations in SMAD4 have been functionally characterized, while the impact of other nonstop mutations remain unknown. Here, we exploit our pan-cancer NonStopDB dataset and test all 2335 C-terminal extensions arising from somatic nonstop mutations in cancer for their impact on protein expression. In a high-throughput screen, 56.1% of the extensions effectively reduce protein abundance. Extensions of multiple tumor suppressor genes like PTEN, APC, B2M, CASP8, CDKN1B and MLH1 are effective and validated for their suppressive impact. Importantly, the effective extensions possess a higher hydrophobicity than the neutral extensions linking C-terminal hydrophobicity with protein destabilization. Analyzing the proteomes of eleven different species reveals conserved patterns of amino acid distribution in the C-terminal regions of all proteins compared to the proteomes like an enrichment of lysine and arginine and a depletion of glycine, leucine, valine and isoleucine across species and kingdoms. These evolutionary selection patterns are disrupted in the cancer-derived effective nonstop extensions.