bluuebunny/crossref_metadata_2025 huggingface dataset:
Estimation of Ursolic acid and Diosgenin in Herbal hair oil formulations used for Hair loss and Grey hair activity by using RP-HPLC Method
Authors: Bhargavi N. Manju , Himanshu T. Makwana , Devang J. Pandya
Published: January 2025

The essential oils have been used for many purposes due to their diverse pharmacological properties and morphological properties. Since it aids in the scalp's efficient absorption of nutrients and stimulates dormant hair follicles, the active fraction has been isolated in this study to examine its potential as a hair growth promoter. Additionally, the phytoconstituent or phytoconstituents responsible for hair growth activity have been identified. The current study's objective is to determine the amount of ursolic acid and dienin in several herbal hair oils with varying formulations using the HPLC technique. The various herbs and oils utilised in this study were used to make herbal hair oil that included important chemical components such as diosgenin and ursolic acid. These elements are in charge of promoting hair development and minimising grey hair. Studies on morphology, chemistry, and pharmacology assessed the oil. By using HPLC method the prepared oils are estimated for Ursolic acid and Diosgenin and one of the formulations has shown with good result.
Stability indicating RP-UPLC method for the simultaneous estimation of Niraparib and Abiraterone in pharmaceutical dosage forms
Authors: Priya DK Shanthi , Mathrusri Annapurna Mukthinuthalapati
Published: January 2025

Niraparib and Abiraterone are anti-cancer agents. A new stability indicating UPLC method has been developed and validated for the simultaneous assay of Niraparib and Abiraterone using Acquity UPLC HSS T3 Column with UV detection at 215 nm within a run time of 3 minutes where Niraparib was eluted at 1.169 min and that of Abiraterone at 0.684 min. Linearity was observed over the concentration range of 2.5-15 µg/mL for Niraparib and 12.5-75 µg/mL for Abiraterone respectively and the regression equations were found to be y=68577x+10960 and y=66848x+7064.7 for Niraparib and Abiraterone respectively. The LOD was found to be 0.32 μg/ml and 0.46 μg/ml whereas the LOQ was found to be 0.98 μg/ml and 1.38 μg/ml for Niraparib and Abiraterone respectively.
Design and Development of Fenoprofen Calcium Tablets for Colone Targeting
Authors: J. Shinde Anilkumar , Surywanshi Vishal , J. Jarag Ravindra , A. Tamboli Firoj , N. More Harinath
Published: January 2025

The objective of the present investigation was to development of enteric coated tablet of fenoprofen calcium. The study results showed that disintegration time and dissolution studies of inner core tablet found to be in the range of 7.15 to 13.34 min and 95.92±0.011% at 30 min. The press coat tablets at optimum concentrations of hydroxy propyl cellulose (200 mg) and ethyl cellulose N-22 (200 mg) showed the % drug release 83.53±0.014% at 12 h, % cumulative drug release of enteric coated tablet of optimized batch FT9 showed 76.08±0.045 at 12h, it indicated that drug release at sustained manner. The presence of EC in hydrophilic compression coat retarded the initial swelling of the coat in weakly acidic pH, but in alkaline pH, enhancement in drug release rate was observed due to the dissolution of EC from the coat with time resulting in a porous coat structure, resulted in a faster and controlled drug release in the target area. The present studies, it was concluded that an optimized formulation successfully delaying drug release for a programmable period of time to attain colon targeted delivery.
Molecular Docking of Carica papaya leaves as Antihypertensive at ACE and Angiotensin II Receptor
Authors: Purnama Gymnastiar Andika , Sri Damayanti Dini , Tilaqza Andri
Published: January 2025

Angiotensin Converting Enzyme (ACE) inhibitor and Angiotensin II Reseptor Blocker (ARB) are a treatment mechanism for patients with hypertension. Papaya leaves have been proven to have the potential to lower blood pressure in hypertensive rat models through the mechanism of ACE inhibition. However, this study has not yet identified the active compounds that act as antihypertensive agents or predicted their safety. This study aims to predict the mechanisms of action of the active compounds in papaya leaves as antihypertensive agents through ACE and Angiotensin II Receptor Type 1 (AT1R) inhibition in silico, and to determine the potential for their development as oral drugs and their safety. The study uses computational design with 3D structures of the target proteins ACE and AT1R downloaded from the Protein Data Bank (PDB). The ligands, which are active compounds from Carica papaya leaves, were obtained from literature, and their 3D structures were downloaded from PubChem. The docking process was carried out using AutoDock Tools. Physicochemical predictions and pharmacokinetics predictions were conducted using the SwissADME and pkCSM websites.The indicators used for the affinity of active compounds are free energy and structural similarity of ligands compared to the drugs control. Solubility and pharmacokinetics follow the 5 criteria of Lipinski's rule, and the values for absorption, distribution, metabolism, and excretion, as well as hepatotoxicity or IC50. The docking results on the ACE protein indicate that the active compounds rutin, luteolin, epicatechin, and caffeic acid have free binding energy values below ∆G -7 kcal/mol. Meanwhile, on the AT1R protein, the active compounds carpaine and rutin show free binding energy values closest to ∆G -7 kcal/mol. Caffeic acid, Carpaine, Epicatechin, and Luteolin have good solubility and meet the 5 criteria of Lipinski's rule.The active compound carpaine has potential on both ACE and AT1R target proteins but exhibits weaker affinity compared to the control drug.
Optimization of Vildagliptin Delivery: Formulation and Evaluation using Box-Behnken Design
Authors: Venkatesh Ranjitha , Abdul Ahad Hindustan , Kumar E Sateesh
Published: January 2025

The presented study focuses on creating and assessing an in situ gastro-retentive gel designed to deliver Vildagliptin accurately to the stomach. The primary objective is to prolong residence time and enhance drug delivery at the targeted site. The synthesis of these gels in situ utilized a cation-controlled gelation method, incorporating various blends and levels of pectin and HPMCK4M. A thorough evaluation encompassed multiple parameters, including visual appearance, pH values, viscosity, in vitro gel formation, in vitro buoyancy, drug content, density, gel force, water absorption, and in vitro drug release. These gels exhibited a total float time exceeding 12 h, with a float delay time of < 2 min. Formulation T-4, characterized by higher levels of pectin and HPMCK4M demonstrated promising cumulative drug discharges of 96.70±3.28%, over 12h. Subsequent in vitro dissolution and stability studies verified consistent active ingredient content, underscoring the stability of the formulations. In summary, the study underscores the efficacy of the developed in situ gels in prolonging gastric residence time, enabling controlled and sustained discharge of Vildagliptin in the stomach, suggesting potential advancements in drug delivery systems.
GC-MS Profiling and antibacterial activity of Acacia nilotica bark pertained aqueous extract
Authors: Manoharan Janani , Shantha Kumari T Parimala , V.R Punithavathi , Dharmalingam Jothinathan Mukesh Kumar , Adaikalam Arulanandam , Anbumani Devipriya
Published: January 2025

The applicability of medicinally imperative plants for well-being of human hold historical background. Products of natural origin are the pivotal source of medicament. Amid all, plant-rooted medicines are the exemplary natural source. The failure of allopathic medicines in terms of their aftereffect have tuned keen interest and practice of medicinal plants and their derivative products. The pharmacologically functional phytophenolics were amendable for the therapeutic attributes of medicinal plants. Acacia nilotica or A.nilotica (Babul/Kikar) an ayurvedic tree was used in this study. Applying soxhlation technique the aqueous bark extract from A.nilotica was pertained. GC-MS chromatogram elucidated 11 bioactive entities, connected with pharmacological traits that included 1,2,3-benzenetriol (Pyrogallol), estra-1,3,5(10)-trien-17β-ol, ethanamine, nonadecane, n-octadecane and pentanoic acid. Furthermore, n-hexadecanoic acid, octanoic acid, 1,2-benzenedicarboxylic acid, benzeneacetic acid and eicosane were recognized in the extract. Pseudomonas aeruginosa (14.6 ± 0.21 mm) displayed greater antibacterial activity, followed by Bacillus cereus (14.4 ± 0.38 mm), Staphylococcus aureus (13.6 ± 0.33 mm), Klebsiella pneumoniae (12.9 ± 0.30 mm), Bacillus subtilis (12.6 ± 0.24 mm) and the least inhibitory zone was given by Escherichia coli (10.2 ± 0.52 mm) at 40 µg/mL. All the outcomes validated the antibacterial attributes of A.nilotica bark pertained aqueous extract.
Analysis of Determinant Factors for Dengue Vaccine Acceptance: Multicentre Cross-Sectional Study of Parents in Southeast Sulawesi, Indonesia
Authors: Ramadhan Salam Muhamad , Apriyanti Rahayu , Rahmat Nurfitriyana , Katadi Syaiful , Idrus Irman , Hasanah Haris Restu Nur , Malina Rachma , Dwi Pemudi Yusniati
Published: January 2025

Dengue fever is caused by the dengue virus (DENV) which is transmitted to humans through mosquito bites (Aedes aegypti) with a high morbidity rate of up to 20% of those affected by dengue fever. In Indonesia, dengue fever has to get the serious attention from various parties because this disease is endemic and threatening the public health. A multicentre cross-sectional approach was carried out on 642 parents in Southeast Sulawesi. The technique sampling used simple random sampling technique. Research data analysis used descriptive and inferential analysis. Descriptive analysis was used to describe sociodemographic characteristics, experiences, knowledge and acceptance of parents in Southeast Sulawesi. Meanwhile, inferential analysis was used to find out the factors that influence the parents’ acceptance in Southeast Sulawesi. The average value of parents' acceptance and knowledge of the dengue vaccine was 77.1% respectively. The results of the chi square test showed that 4 factors directly influenced the acceptance of the dengue vaccine, those were income, experience of knowing about the vaccine, source of information, and level of knowledge of the respondent with p value of <0.05. It is necessary to increase knowledge of the health workers to the parents to increase the awareness of the benefits of dengue vaccine so that parents in Southeast Sulawesi received the dengue vaccine.
Evaluation of natural antioxidants from different varieties of Ficus carica leaves grown in west Sumatera Indonesia
Authors: Mustika Meilinda , Chandra Boy , Misfadhila Sestry , Haris Muhammad , P Sari Dinda , S Mustaqim Muhammad , M Utami Anisa
Published: January 2025

One of the important benefits of fig leaves is their ability as a natural antioxidant. However, further research is needed to comprehensively assess the antioxidant potential of fig leaf extract. The present research aimed to examine the antioxidant activity of ethanol extract and the fraction of five varieties of Ficus carica leaves grown in West Sumatra Indonesia; Panache Tiger (PT), Red Palestine (RP), Green Jordan (GJ), LSU Gold (LG), and Bajihong (BJ). The extraction process uses the Ultrasound-assisted extraction method and the fractionation process uses a separating funnel. Sample solutions were prepared in five concentrations: 4, 8, 12, 16, and 20 µg/ml. Antioxidant testing was carried out using the DPPH (2,2 diphenyl-1-picrylhydrazyl). UV-Vis double beam spectrophotometry measured the absorbance in each sample solution. The IC50 values of ethanol extract F. carica leaves PT, RP, GJ, LG, and BJ varieties were 19.4132; 19.0150; 17.5623; 19.7136; 22.8838 µg/mL, hexane fraction were 84.6393; 84.5263; 83.8990; 85.3026; 87.7560 µg/mL, ethyl acetate fraction were 20.3750; 18.7451; 18,1990; 22.5833; 27.8047 µg/ml and water fraction were 19.7137; 18.2529; 15.9352; 20.6544; 22.9029 µg/ml. The antioxidant activity of the five varieties of F. carica in this study in hydro-alcoholic fraction, ethanol extract, and ethyl acetate fraction was classified into a very strong category, while the hexane fraction was in a strong category. It can be concluded that the F. carica leaves in this study have the potential as antioxidants whereas the Green Jordan variety in hydro-alcoholic fraction has a higher.
HANS JOAS’ “SACRALIZATION THEORY” AS A NORMATIVE CONCEPT
Authors: SZÜCS László Gergely
Published: January 2025

The german social theorist Hans Joas has put forward the thesis that the development of human rights is not to be traced back to anti-religious secularism: what we are talking about here is a peculiar process of sacralization, in the course of which an “aura of sacredness” is created around the members of modern societies. Kantian philosopher Otfried Höffe thinks that Joas strives to create an “affirmative genealogy”: i.e. the elaboration of a method following which we could get an overview of the “authentic history” of the development of human rights and acknowledge the claim to the validity of these rights at the same time. The theory of Joas is seen by Höffe as the unauthorized intervention of a sociologist into the area of rational philosophical argumentation. In my study, I’m trying to outline an answer on Höffe’s criticism. Firstly I’m demonstrating that according Joas’s view the normative philosophy can be replaced by a historical-sociological analysis. Instead, he was thinking in terms of a complementary relationship: he regarded that the involvement of the perspective of historical sociology had a seminal effect on the reconsideration of the familiar normative positions. Secondly that I’m trying to outline Joas’s normative theory in contrast of Habermas’ discourse theory. I am arguing that the outlined theory the development and maintenance of rational discourses depend on preserving certain social practices that evolve spontaneously: consequently, comprehensive social criticism cannot be purely based on the requirement of the discursive rationality. Finally, I will also highlight the problems and restraints of the “Joasian” normative theory.
EMPIRISCHE ADÄQUATHEIT STATT OBJEKTIVER BESCHREIBUNG? EIN KURZER KOMMENTAR ÜBER DIE RELEVANZ DES EPISTEMISCHEN RELATIVISMUS ZUM VERSTEHEN DER WISSENSCHAFT AM BEISPIEL DES KONSTRUKTIVEN EMPIRISMUS BAAS VAN FRAASSENS
Authors: PERSU Darius
Published: January 2025

This analysis is intended as a brief commentary on the relevance of scientific relativism to the understanding of science. This topic is discussed here using the example of Baas van Fraassen's theory, which he developed under the name of “constructive empiricism”. The first part of the text deals with drawing the conceptual framework of what scientific relativism means. Since B. van Fraassen did not explicitly describe his position as relativism, it must be further argued to what extent his theory can be understood in the sense of the definition criteria given in the first point. The concluding considerations are dedicated to presenting some comments on the relevance of epistemic relativism and constructive empiricism for understanding scientific knowledge.
Expansion of the buffalo agri-system and industry following the One Health approach
Authors: Carruyo Gabriela M. , Calderon Ericka , Hoet Armando E.
Published: January 2025

One Health approach is looking for conceiving health as a consequence of interaction in the interphase of the human/animal/environment complex as an interlinked whole, targeting to change how human beings have traditionally managed health. Lessons learned with the recent Covid 19 pandemic and the silent pandemic of antimicrobial resistance (AMR), among others known as potential pandemics, have put on top the need to change how to tackle health threats. The world is constantly challenged by zoonotic diseases, the emergence of new diseases promoted by human ecosystem invasion, climate change, loss of biodiversity, and the inability of nature to restore exhausted ecosystems due to human activity. The increasing world population demands sufficient, safe, and nutritious food, but food production also needs good practices and fair trade. Otherwise, food can become an essential source of illness, disseminating pathogens and AMR, leading to an unsustainable economy. Links between food and health are currently well recognized. Risk assessment and traceability during food production and distribution are crucial to ensure food safety, security, and sustainability. As growing food  producers and suppliers, Buffalo Agri-systems and industry have the opportunity to positively impact the development of sustainable economic systems. Expansion of buffalo Agri-systems and industry will require to be in line with the six areas of action of the One Health Joint Plan of Action 2022-2026 (OH JPA) through incorporation of good production practices, decreasing ecosystem negative impact and processing and distribution of safe food in agreement with national and international standards and guidelines.
Breeding for sustainability: how reproductive biotechnologies can help buffalo farmers combat climate change
Authors: Baruselli Pietro Sampaio , De Abreu Laís Ângelo , Romário de Paula Vanessa , Albertini Sofía , Ferreira dos Santos Guilherme Felipe , Mattos Rebeis Lígia , Almeida Gricio Emanuelle , De Carvalho Nelcio A.T. , Bernardes Otavio
Published: January 2025

The global attention on enteric CH4 production in ruminants requires a response that involves collaboration between researchers and industry. Future generations of buffaloes will be characterized by better efficiency and fertility, which may reduce CH4 emission intensity. This goal will result from balanced multi-trait selection and the introduction of efficient reproductive and productive management. Currently, efficient reproductive programs using assisted reproductive technologies (ARTs) are available on buffalo farms. Our expanding knowledge of ovarian function during the buffalo estrous cycle has given new approaches for precisely synchronizing follicular development and ovulation to apply ARTs consistently. Synchronization protocols are designed to control both luteal and follicular function and permit fixed-time AI with high pregnancy rates during the breeding (autumn-winter) and non-breeding (spring-summer) seasons. Additionally, it allows the initiation of superstimulatory treatments at a self-appointed time, providing opportunities to superstimulate buffaloe donors associated with ovum pick-up (OPU) and in vitro embryo production (IVEP). Furthermore, it allows fixed-time embryo transfer in recipients, with high efficiency and no need for estrus detection. Thus, ARTs, such as AI and ET, are applied for buffalo’s targeted multiplication and dispersal with defined production and environmental credentials. Also, the urgency in moving to the next generation of buffaloes will increase the production of embryos from genomically defined prepubertal heifers. Using these biotechnologies will reduce generation interval and accelerate the rate of genetic improvement to buffalo, defined by better efficiency and fertility and lower CH4 emission. The challenge remains to communicate the importance of buffaloes for food security and the environment.
Važnost stručnog usavršavanja školskih pedagoga za rad s učenicima s problemima u
ponašanju
Authors: Šlogar Iva
Published: January 2025

Učenici s problemima u ponašanju nerijetko su izazov u školskome okružju. Za učenike s problemima u ponašanju školska ustanova predstavlja važan kontekst u socijalizacijskom smislu, a za dionike odgojno-obrazovnog procesa, pa tako i školske pedagoge, rad s učenicima s problemima u ponašanju zahtijeva poseban pristup, koji se ostvaruje i nadograđuje kroz profesionalni razvoj stručnim usavršavanjima. Cilj ovoga rada je istraživanje o povezanosti stručnog usavršavanja školskih pedagoga u tematici rada s učenicima s problemima u ponašanju i realizaciju navedenog u pedagoškoj praksi. Rad prikazuje kvantitativno istraživanje, na uzorku ispitanika od 53 školskih pedagoga Republike Hrvatske. Uzorak ispitanika odnosio se na prigodni neprobabilistički uzorak iz populacije školskih pedagoga, koji je dobrovoljno pristao ispuniti anketni upitnik. Rezultati istraživanja prikazali su kako pedagozi ne procjenjuju kvalitetu dosadašnjeg stručnog usavršavanja u tematici učenika s problemima u ponašanju na visokoj razini. Ipak, rezultati su pokazali važnu povezanost i pozitivnu korelaciju doprinosa stručnog usavršavanja u tematici rada s učenicima s problemima u ponašanju i procjenu kompetencije za rad s učenicima s problemima u ponašanju. Time je prikazano kako stručno usavršavanje stvara pozitivne implikacije u praksi, čime se slažu brojni istraživači.
Kako i na temelju kojih izvora roditelji prikupljaju informacije o rastu i razvoju djece
Authors: Iveković Ivica
Published: January 2025

U današnje vrijeme obrazovanje roditelja za roditeljstvo postalo je sve prisutno. Sama ideja obrazovanja za roditeljstvo usmjerena je na pružanje podrške i povećanje roditeljskih kompetencija. Roditeljima se nude različite mogućnosti obrazovanja i pružanja informacija o rastu, razvoju i odgoju djeteta. Brojna dosadašnja istraživanja pokazuju da roditelji do informacija mogu doći na različite načine. Cilj ovog istraživanja bio je da se utvrditi na koji način roditelji prikupljaju informacije o rastu i razvoju djeteta. Osim toga, istraživanjem se željelo utvrditi prikupljaju li roditelji više informacija prije ili nakon rođenja djeteta te postoji li razlika s obzirom na spol roditelja i djeteta, broj djece, dob i razinu obrazovanja roditelja. Uzorak ispitanika činili su roditelji djece predškolske dobi. Podatci su se prikupljali anketnim upitnikom. Izolirana su tri faktora, odnosno načina na koje roditelji prikupljaju informacije: grupno, individualno i kombinirano grupno-individualno. Rezultati pokazuju da postoje statistički značajne razlike s obzirom na spol roditelja, razinu obrazovanja roditelja, broj djece i spol djece u korištenju izvora informacija. Roditelji prije i nakon rođenja djeteta koriste u drugačijem postotku različite izvore informacija što znači da roditelji prikupljaju informacije o rastu i razvoju djeteta iz drugačijih izvora prije i nakon rođenja djeteta.
English Language Teachers’ Perspectives and Experiences of Teaching English as Cross Interest Subject (EACIS)
Authors: Tartila Tartila
Published: January 2025

Since the issuance of the 2013 curriculum (K13), many Islamic senior secondary schools (MA) offer English as Cross Interest Subject (EaCIS) in addition to compulsory English subject (CES). The subject is designed to help students expand their English language competence beyond their major courses and what they have learnt from CES. Due to a reduction in the number of hours allocated for CES in the K13, teaching EaCIS has become a way for certified English language teachers to accrue the required hours to receive certification payment. This qualitative study was designed to understand teachers' perceptions and experiences of teaching EaCIS and shares the findings from the interview and focus group data collected from six English language teachers teaching at state Islamic senior secondary schools (MAN) in Indonesia. Findings reveal that whilst EaCIS provides an opportunity for teachers to improve student's English abilities, none of the participants received support to teach it. Whilst it is acknowledged that this is a small study and the findings cannot be generalised to the broader population of teachers responsible for teaching EaCIS, the experiences shared by participants provide valuable and interesting insights into curriculum change. Recommendations for improving the implementation of EaCIS and the future design of curriculum change initiatives in Indonesia are discussed.Keywords: English as Cross Interest Subject, teacher experiences, teacher perceptions, curriculum change, K13 curriculum
English Learning in Primary School 2 Kenteng Nogosari (Ethnographic Research at SD Negeri 2 Kenteng Nogosari)
Authors: Palupi Rismaka , Sujito Sujito
Published: January 2025

The study aims to gain a deep and comprehensive understanding of the English learning process of students of Grade II SD N 2 Kenteng Nogosari using ethnographic method in a qualitative approach. This process includes the roles of teachers and learners. Teachers can create a good learning atmosphere, have a positive impact on students' learning and achieve optimal learning outcomes. She is also the director of individual and group activities. Learners will always feel safe because teachers care about their students throughout the independent learning process. This approach is based on assumptions about the nature of language and how language learning occurs. Learning English is about developing contextual skills and acceptable English. It depends on the context, conditions and everyday circumstances of the learner. We recommend integrating research findings into popular teaching materials that are appropriate to the needs of students
Características da dor musculoesquelética em indivíduos com hipertensão arterial sistêmica de uma comunidade ribeirinha
Authors: Ribeiro Daylon Brenon Cardoso , Costa Camila Vitória de Moraes , Pinto Guilherme Gonçalves Silva , Alves Geovanna Cristina Pereira , Cardoso Thayllane Costa , Bassi-Dibai Daniela , Mendonça Rita de Cássia de Miranda , Gonçalves Maria Claudia
Published: January 2025

Introdução: A hipertensão arterial sistêmica e a dor musculoesquelética apresentam taxas de prevalência na população. Objetivo: objetivo desse trabalho foi caracterizar a intensidade da dor musculoesquelética e os níveis pressóricos em indivíduos de uma cidade ribeirinha. Métodos: Estudo transversal realizado em duas comunidades no município de Arari, Maranhão, em março a abril de 2019. Os sintomas musculoesqueléticos foram avaliados através do Questionário Nórdico e os níveis pressóricos mensurados pelo esfigmomanômetro digital. A análise estatística foi realizada no software Stata 14, a correlação entre os níveis pressóricos e intensidade da dor foi verificada com a correlação de Spearman. Resultados: As médias dos níveis pressóricos foram de 135,86mmHg (sistólica) e 86,45mmHg (diastólica). A análise de correlação entre níveis pressóricos e intensidade da dor demonstrou valores significativos entre os níveis diastólicos e as regiões da coluna torácica, lombar e tornozelos. Conclusão: Os resultados demonstram correlação negativa entre níveis pressóricos e intensidade da dor musculoesquelética.
Perfil epidemiológico da Leishmaniose Tegumentar Americana em Imperatriz entre anos de 2012 e 2022
Authors: Miranda Mel Cristinne Coelho , Cavalcanti Bruna Lima Durans , Freitas Marcos Marcelo Barbosa , Lima Jaqueline Rêgo , Soares Giovana Balbinot , Fróes Giulian Araújo , Nunes Alexandre Sousa , Alves Matheus Silva
Published: January 2025

Introdução: A Leishmaniose Tegumentar Americana (LTA) é uma doença infecciosa crônica desencadeada por protozoários do gênero Leishmania, podendo se manifestar nas formas cutânea, mucosa ou cutâneo-mucosa. Apresenta-se como uma patologia negligenciada, representando um desafio para saúde pública, com destaque para a cidade de Imperatriz-MA, que é endêmica para a LTA. Objetivo: Objetiva-se determinar o perfil epidemiológico da LTA no município de Imperatriz-MA entre os anos de 2012 e 2022. Material e Métodos: Trata-se de estudo descritivo, ecológico, retrospectivo e quantitativo realizado utilizando dados secundários sobre casos de LTA no município de Imperatriz-MA no período de 2012 a 2022. Os dados coletados foram obtidos do SINAN. Foram utilizadas variáveis agrupadas de gênero, idade, etnia, nível de escolaridade, evolução da doença, forma clínica e média mensal, avaliando a sazonalidade da doença. A incidência foi calculada a partir da quantidade de casos novos sobre a população do estado multiplicado por 100.000. Resultados e Discussões: Foram notificados 410 casos de LTA no período avaliado, sendo 80% do sexo masculino, 34,47% entre 40 e 59 anos, 61,46% de etnia parda, 30,48% com ensino médio completo, 90,48% em forma cutânea, 85,60% curados e média mensal de 5,5 em julho. Conclusão: Concluiu-se que homens pardos, de 40 a 59 anos e ensino médio completo são os mais afetados, a maioria dos casos são na forma cutânea e evoluem para a cura, sendo necessária a implantação de medidas direcionadas em buscando combater essa enfermidade em meio a essa população de risco.
Advancing Sustainable Marine Transportation: Offshore Floating Electric Vessel Charging Stations
Authors: V Sruthy , Preetha P K
Published: January 2025

The feasibility analysis of offshore floating charging stations (FCS) incorporating renewable energy sources (RES) in India and around the world presents a promising and pioneering solution to meet the emerging demands of maritime transport systems for sustainable development. The global shift towards sustainable transportation supports the increasing adoption of electric vessels (E-vessel), which forces the inclusion of innovative solutions for their reliable operation. This study includes a feasibility analysis of FCS combined with an energy management system for reliable operation. A real-time analysis was conducted at an offshore location in the Arabian Sea, near Gujrat, India, to assess the operational and implementation possibilities of FCSs in India, especially in the Exclusive Economic Zone (EEZ). An appropriate energy management system in the FCS tackles E-vessel demand changes, real-time variations in RES, and energy flow balance with reduced reliance on backup energy systems. The findings demonstrated a reduction of 70.2% in the backup energy requirement for the FCS, and the energy management system ensured that the FCS had an immense improvement in excess RES support to meet additional E-vessel demands. This paper also included a comparative analysis between an offshore location in India and one in Europe. This study underscores the potential of FCS to enhance the adoption of E-vessels in India’s and global marine transportation.
Stenotic Intercondylar Notch as a Risk Factor for Physeal-Sparing ACL Reconstruction Failure: A Case-Control Study
Authors: Tuca María , Gausden Elizabeth , Luderowski Eva , Valderrama Ignacio , Potter Hollis , Cordasco Frank , Green Daniel
Published: January 2025

Introduction:

Identifying risk factors is crucial for developing strategies that minimize reinjury after anterior cruciate ligament reconstruction (ACLR). This study aims to determine whether certain features of intercondylar notch geometry are associated with failure of physeal-sparing ACLRs in skeletally immature athletes.

Methods:

Nine failed physeal-sparing ACLRs were compared with a control subject group of 15 age- and sex-matched intact physeal-sparing ACLRs. Notch width index (NWI), notch angle (NA), and intercondylar notch roof inclination angle (RA) were measured on preoperative MRIs.

Results:

Median NWI was smaller in the failed ACLR versus control subject group in coronal (0.23 versus 0.27; P < 0.05) and axial planes (0.25 versus 0.27; P = 0.055). Median NA was smaller in the failed ACLR versus control subject group in coronal (49.6 versus 61.0°; P < 0.05) and axial planes (48.6° versus 54.9°; P < 0.05). Median RA was steeper in the failed ACLR versus control subject group (132.0° versus 125.7°; P < 0.05).

Conclusion:

NWI, NA, and RA were associated with ACLR failure in skeletally immature patients undergoing physeal-sparing reconstruction. A smaller, narrower, and steeper notch may predispose these patients to reinjury.

Level of Evidence:

Level III, retrospective comparative study.
Retrospektive Studie zur Validierung & Entwicklung einer objektiven Beurteilung des konjunktivalen Rötungsgrades mittels Videotopographen
Authors: Sickenberger Wolfgang , Marx Sebastian
Published: January 2025

Purpose. The purpose of this exploratory study was to evaluate and validate the objective determination of bulbar, limbal and total conjunctival redness with the K5M video topographer (Oculus, Germany), the measurement software (R-Scan) and the JENVIS grading scale in comparison to subjectively recorded redness levels.

Material and Methods. The conjunctival redness level was documented three consecutive times in a total of 75 subjects (150 eyes). The average age was 33.9 ± 15.7 years. The survey took place at the Centre for Contact Lens Research Waterloo, Canada and at the Helios hospital Erfurt, Germany. From the survey, 25 images were selected and entered into a website for subjective grading. On the website, the images were presented in a randomized order six times (3× limbal & 3× bulbar redness), so that each of the 20 investigators graded a total of 150 images. The reference images of the redness grades were based on the JENVIS grading scale. The subjective results were compared using the five analyzed grades with the objective findings by the R-Scan of the K5M. The results were analyzed using descriptive statistics.

Results. With regard to the images obtained using the software, the mean grade of findings was 1.3 ± 0.3, with 24 % of the results being assessed as grade 0, 48 % as grade 1, 14 % as grade 2 and grade 3. The subjective findings resulted in a mean grade of 1.5 ± 0.3. 17 % were assessed as grade 0, 45 % as grade 1, 19 % as grade 2 and 5 % as grade 3. The results of the subjective and objective classification of temporal and nasal bulbar redness are not statistically different. In contrast, the results of temporal and nasal limbal redness are statistically different, with the subjective findings within grade 1 being statistically significantly higher than those of the objective findings. The mean dispersion of the objective classifications is 11 %, that of the subjective 31 %.

Conclusion. The software (R-Scan, K5M) primarily evaluates the number and redness of the conjunctival vessels, whereas the subjective evaluation is based on the overall redness of the eye as perceived by the examiner. As the degree of severity increases, the spread of the results increases with objective classification, but decreases with subjective classification, with the latter showing an almost 3-times greater spread on average. This means that automated conjunctival classifications are more accurate than subjective classifications for lower degrees of severity and comparable for higher degrees of severity.
Factors Affecting the Tourism Sector in India
Authors: Das Gourab , Pyne Radhanath
Published: January 2025

Tourism is one of the most important revenue-earning industries in the Indian economy. The number of tourist inflow, both domestic and foreign, has been increasing over the years. Different social and economic factors directly influence this tourist inflow. The maximum inflow of tourists helps to develop the economy of any state in India. This paper shows the relationship of those factors to the development of tourism in India. Development of tourism flourishes in the states with rich socio-economic factors than the states with underdevelopment factors.
Grupos parlamentarios y contexto institucional
Authors:   UNED, Jaime Castillo Antonio M. , Martínez Cousinou Gloria ,   Universidad Loyola Andalucía
Published: January 2025

La hipótesis de partida que se plantea, consistente con el trabajo de Jaime y Martínez-Cousinou (2013), es que el sistema electoral proporcional basado en listas cerradas y bloqueadas tiene dos efectos principales. Por un lado, genera una elevada disciplina de partidos. El resto del capítulo se organiza en cinco apartados. En la siguiente sección, se presenta un breve bosquejo de la relación entre sistema electoral y la disciplina de partido, tal como ha sido analizada en la literatura previa. A continuación, se presentan específicamente los datos del caso español sobre disciplina de partidos. Los dos apartados siguientes se dedican al proceso de toma de decisiones y al perfil de los líderes dentro de los grupos parlamentarios. El capítulo termina con una sección de conclusiones en la que se sintetizan los principales resultados y sus implicaciones.
INTEGRATEDCROP MANAGEMENT SYSTEM
Authors: Jerard Dr . Joseph M , L YOGESHWAR , GOWDA NISCHITH S , GOWDA RAMPRAKASH
Published: January 2025

The goal of the machine learning-based
Crop Management System is to
increase agricultural productivity. It
helps farmers by providing features
like yield forecasting, rainfall
prediction, crop prediction, and
fertilizer advice. The system analyzes
important variables like rainfall,
temperature, humidity, and soil type to
provide useful information for
improving farming methods. Utilizing
machine learning frameworks such as
Scikit-learn and Python and PHP, the

project uses predictive algorithms to
provide customized suggestions for
crop management and selection. This
application addresses issues like
resource optimization and climatic
unpredictability while enabling farmers
to make data-driven decisions that
increase agricultural sustainability and
efficiency. The system has the friendly
interfaces and accessibility
for a farmer with even lower technical
background to use in its operations.
IOT Based Air Pollution Detection and Monitoring Using Arduino
Authors:   Assistant Professor, ECE & IARE, Veeraswamy D
Published: January 2025

Air pollution poses a significant threat to the environment and public health, highlighting the need for effective monitoring systems. This paper introduces an IoT-based air pollution detection and monitoring system built using Arduino. The system incorporates sensors such as MQ135  to measure key pollutants, including carbon dioxide (CO₂), carbon monoxide (CO), and particulate matter. Arduino processes the collected data and transmits it to a cloud platform via Wi-Fi or GSM modules, enabling real-time monitoring and remote access through web or mobile applications .The system also generates alerts when pollutant levels surpass predefined safety thresholds, promoting timely interventions. Its low-cost and modular design ensure scalability and adaptability for various applications, including urban, industrial, and residential environments. The proposed solution demonstrates its reliability and potential in enhancing environmental monitoring and facilitating data-driven pollution management strategies.

Key Words:  IoT, Arduino, air pollution monitoring, real-time data, sensors, environmental management
Envejecimiento en casa: exploración y aplicación de metodología cualitativa
Authors: Pérez-Duarte Fernández Alejandro , Enríquez Rosas Maria del Rocio
Published: January 2025

Los estudios sobre envejecimiento, vivienda y ciudad han adquirido relevancia en las últimas décadas, en especial la modalidad del envejecimiento en casa, de la cual se tienen hoy diversos caminos metodológicos, la mayoría de orden cualitativo. Una de las complejidades de su puesta en práctica es la documentación del ambiente doméstico, las actividades cotidianas al interior y exterior de la vivienda, así como también el perfil de la persona. Se describe una metodología enfocada en el trinomio persona-vivienda-entorno urbano caminable, partiendo del principio de que constituye una unidad indisociable y simbiótica donde pueden ser promovidas autonomía, socialización, salud psicosocioemocional y autocuidado. Se construyó una base de datos con entrevistas, fotografías, mapa del área inmediata y una planta arquitectónica esquemática de la casa, que fue analizada por un grupo multidisciplinario de investigadores. El proceso metodológico, puesto a punto y aplicado sobre 18 casos de estudio, permite analizar el ambiente doméstico bajo la perspectiva gerontológica y ofrece posibilidades para futuras directrices de una producción habitacional resiliente para población en “proceso de envejecimiento”.
NIVELES DE COMPRENSIÓN GRÁFICA DE ESTUDIANTES FRENTE A PREGUNTAS ENFOCADAS EN LA TOMA DE DECISIONES
Authors: Irarrázaval Felipe , Jiménez Javiera , García Jaime , Arredondo Elizabeth
Published: January 2025

Para tomar decisiones informadas, el ciudadano común se enfrenta al desafío de leer, interpretar y analizar datos representados en gráficos estadísticos. En este estudio, exploratorio y descriptivo, se analiza el nivel de comprensión gráfica que evidencia un grupo de estudiantes chilenos de educación media cuando se enfrentan a preguntas enfocadas en la toma de decisiones con base en un contexto cercano, de acuerdo con la jerarquía propuesta por García-García y colaboradores. En general, la mayoría del estudiantado evidencia aspectos del nivel cuatro, integrativo, al realizar una integración con el contexto a partir del análisis de l5s datos y las variables contextuales que se muestran en el gráfico. Aunque esta proporción significativa de estudiantes es capaz de hacer asociaciones apropiadas entre datos, el nivel de toma de decisiones de otros está respaldado únicamente por creencias personales sobre el contexto. Lo anterior nos permitirá, para futuros estudios, diseñar actividades para ayudar al estudiantado a tomar decisiones basadas en el análisis de datos.
Problématique de l’insertion sociale des jeunes consommateurs des produits psychotropes à Brazzaville : cas du Tramadol
Authors: NGAGNON Aimé Rufin
Published: January 2025

Cette étude de type transversal, portant sur la « problématique de l’insertion sociale des jeunes consommateurs des produits psychotropes à Brazzaville : cas du tramadol», a été menée au moment où l’usage des produits psychotropes, comme le tramadol par la couche juvénile, a pris de l’ampleur tant à Brazzaville que dans les autres villes congolaises. Produit antalgique à son origine, le tramadol est la cause de plusieurs maux à Brazzaville : viol, braquage, vol, assassinats. Cette étude se propose d’analyser les causes de la non-intégration sociale des jeunes consommateurs du tramadol et de montrer l’impact de ce produit sur le comportement de ces derniers.Les résultats de cette recherche, obtenus à partir des questionnaires et des entretiens auprès de 25 jeunes consommateurs, 15 vendeurs, 4 psychologues et 10 parents, ont permis de découvrir les réelles motivations de ces jeunes consommateurs du tramadol ; et par conséquent constituent un argumentaire pour le plaidoyer de la lutte contre le trafic et la vente illicite des stupéfiants sur toute l’étendue de la République du Congo.
Enseignant comme tuteur de résilience : Une exploration de la stratégie des inférences dans l’enseignement de la lecture compréhension aux Cours Moyens
Authors: KOUYIMOUSSOU Virginie
Published: January 2025

Cet article examine la place du savoir d’expérience dans les pratiques pédagogiques d’enseignement des inférences en lecture compréhension et montre le rôle du tuteur de résilience que joue l’enseignant. Nous avons eu recours à une méthodologie de nature qualitative. Nos instruments de recueil des données sont : l’entrevue semi-dirigée auprès des enseignants de CM1-CM2 du primaire, la démarche didactique de la lecture compréhension et la grille d’observation d’une leçon. Les résultats de la recherche nous révèlent que les enseignants, dans la réalisation de leurs activités quotidiennes ont plus recourent à leur expérience professionnelle et à la maîtrise des stratégies efficaces. Ces gestes professionnels que les enseignants installent au coeur de la classe les conduisent effectivement à jouer leur rôle de tuteur de résilience en aidant les apprenants du CM1-CM2 à développer leur capacité en compréhension de lecture et à faire des inférences quand ils lisent un texte.
Analyse descriptive des pratiques pédagogiques d’éducation inclusive dans les écoles primaires de Mô au Togo
Authors: BAWA Ibn Habib , YOVOGAN Kossi Edem
Published: January 2025

Le point 4 des Objectifs de Développement Durable (ODD4) stipule d’« assurer l’accès de tous à une éducation de qualité, sur un pied d’égalité, et promouvoir les possibilités d’apprentissage tout au long de la vie » (ONU, 2015 sur www.globalcompact-france.org). Sur ce, tous les systèmes éducatifs doivent être plus inclusifs. Le Togo avec l’appui de Plan-International Togo a mis sur pied un projet d’‘’éducation inclusive’’ afin de faciliter aux enfants handicapés, l’accès aux écoles ordinaires. La présente étude cherche à vérifier le respect des exigences pédagogiques de l’éducation inclusive en s’informant sur la qualification et les pratiques pédagogiques des enseignants des classes inclusives dans le cadre de ce projet dans la préfecture de Mô. La question principale est de savoir si les enseignants ont une qualification en éducation inclusive et si leurs pratiques pédagogiques correspondent-elles à ce type d’éducation. À partir d’un questionnaire semi-ouvert, nous avons interrogé les enseignants sur leur qualification et leurs pratiques pédagogiques en classes inclusives. Le logiciel Sphinx a permis de traiter les données et les résultats montrent que les enseignants ne sont pas qualifiés et par conséquent leurs pratiques pédagogiques y compris les méthodes d’évaluation ne sont pas adaptées. Ce qui se traduit par des difficultés majeures dans la prise en compte effective des élèves en situation de handicap dans les classes dites inclusives.
Impact du petit déjeuner dans l’apprentissage et le rendement scolaire des apprenants du primaire de la circonscription de Bacongo, (Brazzaville)
Authors: OKÉMY ANDISSA Nadège , MOUSSAVOU Guy , MOUDILOU Moïse Servais Amédée , OBANDA Laurence
Published: January 2025

Ce travail de recherche s’intéresse à « l’impact de l’apport du petit déjeuner sur l’apprentissage et le rendement scolaire des apprenants de la circonscription de Bacongo ». Son objectif est   de garantir l’éducation des écoliers par l’apport nutritionnel. La méthodologie sur l’approche de l’enquête sur le terrain a été menée et la collecte des données s’est réalisée à travers le questionnaire et les interviews directes avec la population cible. Les résultats issus de cette investigation ont montré qu’environ 72% des encadreurs pensent que la prise du petit déjeuner par les apprenants, les maintiens en éveil, les motive et booste leurs performances de compréhension des contenus notionnels. De même que, 63% des élèves confirment que les sauts du petit déjeuner seraient le facteur bloquant pour leurs réussites scolaires. De ce fait, on peut supposer que la création des cantines scolaires serait une résolution efficace pour augmenter les compétences intellectuelles et des apprenants du primaire.
Situation des infrastructures éducatives dans un contexte d’insécurité dans la région du sahel au Burkina Faso
Authors: Seydou SERE
Published: January 2025

La région du Sahel fait partie des régions fortement touchées par l’insécurité au Burkina Faso.Sur les 1 098 177 habitants que compte la région (INSD, 2019), environ 574 000 sont desPersonnes Déplacées Internes (PDI) (CONASUR, 2022). L’éducation fait partie des secteursles plus touchées par l’insécurité. Pour la seule ville de Dori environ 62,02% des 14 256 PDIsont des enfants et pour la majorité en âge d’aller à l’école (OCHA1, 2022). Cette insécurité liéeaux actes terroristes a entrainé ainsi la fermeture de nombreux établissements scolaires. Dansce contexte difficile, que reste-il des infrastructures éducatives. Comment se présente la cartescolaire de la région du sahel ? Cette recherche se pose la question sur la situation desinfrastructures éducatives dans un contexte d’insécurité dans la région du Sahel au BurkinaFaso. Elle interroge la fonctionnalité et l’équipement des infrastructures éducatives au niveauprimaire et secondaire. La méthodologie repose sur l’analyse des données collectées par laDirection générale du développement territorial du 14 au 25 mars 2022 à laquelle nous avonspris part. Il s’agit d’un recensement de toutes les infrastructures éducatives de l’ensemble descommunes de la région du Sahel. L’état de ces infrastructures ainsi que leur fonctionnalité ontété également renseignés. La collecte s’est faite à l’aide de l’application de collecte de donnéesKoBoCollect, installée sur des smartphones dans lesquels étaient déployés le questionnaire.Cela a eu pour avantages la collecte rapide des données par les points focaux des communes etla géolocalisation des infrastructures. La collecte a permis de géolocaliser 1 232 infrastructureséducatives dont 888 écoles primaires du public et du privé.