bluuebunny/crossref_metadata_2025 huggingface dataset:
Control for Wind Turbine System using PMSG when Wind Speed Changes
Authors: Minh Pham Van
Published: June 2024

This paper presents the proposed model to control grid-connected wind turbine by permanent magnet synchronous generator (PMSG). With the wind speed changing continuously, the rotor system needs to be able to self-regulate according to wind speed and direction to ensure efficient operation of the turbine. The PMSG was chosen because the magnetic flux is always available thanks to the permanent magnet system glued to the rotor surface. The generator provides power with low rotational speed but high efficiency. These are the important advantages of using PMSG for wind turbine. Matlab - Simulink software was used to design the controllers and the survey results proved that this control system meets the power quality requirements when connecting to the grid and optimizing the energy conversion process for turbine wind.
Application of immune checkpoint inhibitors and microsatellite instability in gastric cancer
Authors: Yan Shi-Yan , Fan Jian-Gao
Published: June 2024

In this editorial we comment on the article by Li published in the recent issue of the World Journal of Gastroenterology . We focus specifically on the application of immune checkpoint inhibitors (ICIs) and microsatellite instability (MSI) in gastric cancer (GC). The four pillars of GC management have long been considered, including surgery, chemotherapy, radiotherapy and targeted therapy. However, immunotherapy has recently emerged as a ”fifth pillar”, and its use is rapidly expanding. There are four principal strategies for tumor immunotherapy: ICIs, tumor vaccines, adoptive immunotherapy and nonspecific immunomodulators. Of them, ICIs are the most advanced and widespread type of cancer immunotherapy for GC. Recent breakthrough results for ICIs have paved the way to a new era of cancer immunotherapy. In particular, inhibition of the PD-1/PD-L1 axis with ICIs, including nivolumab and pembrolizumab, has emerged as a novel treatment strategy for advanced GC. Unfortunately, these therapies are sometimes associated with often subtle, potentially fatal immune-related adverse events (irAEs), including dermatitis, diarrhea, colitis, endocrinopathy, hepatotoxicity, neuropathy and pneumonitis. We must be aware of these irAEs and improve the detection of these processes to prevent inappropriate discharges, emergency department revisits, and downstream complications. Recent studies have revealed that MSI-high or mismatch- repair-deficient tumors, regardless of their primary site, have a promising response to ICIs. So, it is important to detect MSI before applying ICIs for treatment of GC.
Effects of proton pump inhibitors on inflammatory bowel disease: An updated review
Authors: Liang Yu , Meng Zhen , Ding Xue-Li , Jiang Man
Published: June 2024

Inflammatory bowel disease (IBD) is believed to be caused by various factors, including abnormalities in disease susceptibility genes, environmental factors, immune factors, and intestinal bacteria. Proton pump inhibitors (PPIs) are the primary drugs used to treat acid-related diseases. They are also commonly prescribed to patients with IBD. Recent studies have suggested a potential association between the use of certain medications, such as PPIs, and the occurrence and progression of IBD. In this review, we summarize the potential impact of PPIs on IBD and analyze the underlying mechanisms. Our findings may provide insights for conducting further investigations into the effects of PPIs on IBD and serve as an important reminder for physicians to exercise caution when prescribing PPIs to patients with IBD.
Smarte Digitalisierung ermöglicht erfolgreiche Transformation
Authors: Wieberneit Stefan , Beck Alexander
Published: June 2024

Wandel allerorten: Energieversorgungsunternehmen müssen in einem reißenden Strom technischer und marktlicher Entwicklungen festen Stand bewahren. Die alten Werkzeuge für das operative Geschäft taugen nicht mehr. Warum es so wichtig ist, bei der IT-Unterstützung die richtige Wahl zu treffen und auf zukunftsfähige Konzepte zu setzen, zeigt dieser Beitrag von Arvato Systems.
Häuser für 100 Jahre
Authors: Pang Baogen
Published: June 2024

Energieeffiziente Häuser finden auch in China Anklang. Dort hat ein Unternehmen mit einer chinesischen Normungsorganisation einen Standard für ein Niedrigenergiehaus entwickelt. Diese Häuser sind für eine Lebensdauer von 100 Jahren konzipiert.
Großer Staudamm digital überwacht
Authors: DiMatteo Sandra
Published: June 2024

In Kalifornien überwacht eine kommunale Behörde einen Staudamm mit der intelligenten Software eines US-amerikanischen Unternehmens. Dies hilft der Behörde, dessen Stabilität zu überwachen. Sie spart dadurch Ausgaben ein und setzt Mitarbeiterinnen und Mitarbeiter keinen unnötigen Risiken mehr aus.
Knowledge revision processes during reading: How pictures influence the activation of outdated information
Authors: Frick Pauline , Kendeou Panayiota , Schüler Anne
Published: June 2024

Outdated information (i.e., information that is not or no longer accurate) continues to be automatically activated during reading and can hinder learning processes. Thus, it is important to understand which factors influence the activation of outdated information and, therefore, knowledge revision processes. In three online experiments, we investigated how illustrating updated or outdated information via pictures influences the activation of outdated information. In Experiments 1 (N = 421) and 2 (N = 422), we varied whether participants read texts containing outdated information that was later updated (outdated text) or texts containing only updated information (consistent text). In addition, the updated information was or was not illustrated by a picture. In Experiment 3 (N = 441), participants read outdated texts, and we varied whether the outdated, the updated, or no information was illustrated. In all experiments, we measured reading times for a target sentence referring to the updated information and the sentence following the target sentence. Results showed that target sentences’ reading times were faster for illustrated than for non-illustrated texts (Experiments 1 and 2). Moreover, reading times were longer when the outdated information was illustrated than when the updated information was illustrated (Experiment 3). These results suggest that pictures overall facilitate cognitive processes during reading, but their content matters: Pictures showing the updated information had a greater impact on reading times than pictures showing the outdated information. The results extend existing theories on knowledge revision but also reading comprehension, by demonstrating how pictures might influence cognitive processes during reading.
Auditory context-dependent distraction by unexpected visual stimuli
Authors: Parmentier Fabrice B. R. , English Michael , Maybery Murray T.
Published: June 2024

Research findings indicate that when a task-irrelevant stimulus feature deviates from an otherwise predictable pattern, participants performing a categorization task exhibit slower responses (deviance distraction). This deviance distraction effect reflects the violation of the sensory predictions generated by the cognitive system. In this study, we sought to examine for the first time whether these predictions can be incidentally modulated by the auditory environment. Participants categorized the duration (short vs long) of a colored shape (red square or blue circle) while instructed to disregard the stimulus’ visual features and the sound played in the background (two distinct chords played by different instruments). While the two visual stimuli shapes were equiprobable across the task, one was highly likely (p=.882) and the other rare (p=.118) in one auditory context and vice versa in the other context. Our results showed that participants were significantly slower in the duration judgement task whenever the stimulus was unexpected within a given auditory context (context-dependent distraction), and that the reset of their sensory predictions was completed upon the trial following a change of context. We conclude that object features and environmental context are processed in relation to each other and that sensory predictions are produced in relation to the environmental context, evidencing the first demonstration of auditory context-dependent modulation of attention.
Peran Perdata Notaris Dalam Pembuatan Akta Perjanjian Kawin Pasca Putusan Mahkamah Konstitusi No.69/PUU-XIII/2015 (Studi Pada Notaris di Wilayah Hukum Kota Malang)
Authors: Suaib Sri Olawati , Ibrahim Arif Mahfudin
Published: June 2024

Tujuan dari penelitian ini adalah untuk menganalisis dan merumuskan peran notaris pasca putusan Undang-Undang Dasar Nomor 69/PUU-XIII/2015 terhadap isi akad nikah dan menganalisis dan merumuskan bentuk tanggung jawab perdata notaris. dalam pembuatan akad nikah pasca putusan UU Tata Negara Nomor 69/PUU-XIII/2015. Hasil yang diperoleh dari penelitian ini mengungkapkan bahwa dalam putusan Undang-Undang Dasar Nomor 69/PUU-XIII/2015 terhadap isi akad nikah pada mulanya dapat dikonstruksikan pada saat atau sebelum pernikahan. Namun demikian, setelah putusan UUD, akad dapat dilakukan tidak hanya pada saat dan sebelum perkawinan, tetapi pada saat perkawinan, akad dapat dilakukan oleh suami istri yang takarannya tidak hanya berlaku bagi perkawinan campuran tetapi juga perkawinan. secara umum. Dengan demikian, peran notaris dalam pembuatan akad nikah pasca putusan pada hakekatnya sangat diperlukan untuk memberikan kepastian dan perlindungan hukum bagi para pihak yang menandatangani akad tersebut. Selain itu, bentuk tanggung jawab perdata notaris dalam membuat akad nikah menurut putusan Undang-Undang Dasar Nomor 69/PUU-XIII/2015 terhadap isi akad nikah, dalam hal pengaturan akad nikah, terbatas pada formalitas kontrak yang dibuat, sedangkan para pihak bertanggung jawab penuh terhadap isi dan esensi kontrak. Notaris adalah sebagai pejabat umum yang berhak secara tertulis atas kemauan dan persetujuan suami istri atas akad tersebut.
Adli Toksikoloji Klinik, Nöropsikiyatrik ve Postmortem Değerlendirme
Authors: Işık Cihangir , Öztuna Şeyda
Published: June 2024

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Psikopatolojiye Giriş
Authors: Yıldız Muhammed
Published: June 2024

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Konsep Diri dan Disposisi Matematis: Bagaimana Hubungan Terhadap Hasil Belajar Siswa Sekolah Dasar?
Authors: Fridolin Vrosansen Borolla  , Sumarah Suryaningrum  , Hediaty La Sitiman
Published: June 2024

The research objective was to determine the relationship between self-concept and learning outcomes, determine the relationship between mathematical dispositions and learning outcomes, and determine the relationship between self-concept and mathematical disposition on learning outcomes. The study used a survey method with correlation techniques for fourth-grade students. The results showed that 1) there was a positive relationship between self-concept and learning outcomes; 2) there is a positive relationship between mathematical dispositions and student learning outcomes, and 3) there is a positive relationship between self-concept and mathematical dispositions on learning outcomes. Thus, the study results can be concluded that the learning outcomes of elementary school students have a positive relationship between self-concept and mathematical disposition
Induksi dan Kultur Suspensi Friable Embryogenic Callus Ubi Kayu Menggunakan Kultivar Lokal dan Jenis Auksin yang Berbeda
Authors: Simamora Endah Cahyani , Slameto Slameto , Restanto Didik Pudji
Published: June 2024

Tanaman ubi kayu (Manihot Esculenta) merupakan komoditas yang diprioritaskan serta mudah untuk dibudidayakan. Perakitan tanaman ubi kayu memiliki kesulitan dikembangkan secara generatif sehingga dibutuhkan pendekatan kultur jaringan melalui induksi Friable Embryogenic Callus. Beberapa kendala dalam menghasilkan kalus yang embriogenik yaitu genotip serta eksplorasi dari metode dan protokol induksi FEC dari beberapa varietas ubi kayu masih terbatas. Penelitian dilakukan dengan beberapa tahapan yaitu induksi FEC pada media GD dengan perlakuan kultivar yang berbeda yaitu Kaspro (V1), Ketan (V2), Kuning (V3) pada media GD, dilanjutkan dengan proliferasi pada kultur suspensi dengan perlakuan jenis auksin yaitu picloram 12 mg.L-1 (P1), 20 mg.L-1 (P1), dan 2,4-D 12 mg.L-1 (P3) dan perbedaan kultivar. Hasil penelitian yang diperoleh yaitu respon kalus dari kultivar lokal menunjukkan rerata frekuensi dan skor FEC tertinggi terdapat pada Kultivar Kaspro sebesar 51,26% dan skor 4 sebagai kategori kemampuan membentuk FEC tinggi. Pertambahan berat segar tertinggi terdapat pada perlakuan P1 yaitu 1,19 gram serta perlakuan V2P1 yaitu 0,64 gram. Volume suspensi tertinggi terdapat pada perlakuan V1P2 serta viabilitas sel tertinggi terdapat pada perlakuan V3P2.TRANSLATE with x EnglishArabicHebrewPolishBulgarianHindiPortugueseCatalanHmong DawRomanianChinese SimplifiedHungarianRussianChinese TraditionalIndonesianSlovakCzechItalianSlovenianDanishJapaneseSpanishDutchKlingonSwedishEnglishKoreanThaiEstonianLatvianTurkishFinnishLithuanianUkrainianFrenchMalayUrduGermanMalteseVietnameseGreekNorwegianWelshHaitian CreolePersian //  TRANSLATE with COPY THE URL BELOW Back EMBED THE SNIPPET BELOW IN YOUR SITE Enable collaborative features and customize widget: Bing Webmaster PortalBack//
Factors Affecting Telang (Clitoria ternatea L.) Germination: Systematic Literature Review
Authors: Kuswantoro Farid , Li'aini Arrohmatus Syafaqoh
Published: June 2024

Clitoria ternatea is a multipurpose plant species. Interest in this plant species has increased recently as its antioxidant properties made it a popular natural food additive. This condition implies that a review study to understand the current development of C. ternatea germination biology, especially factors affecting its germination, is essential to help interested stakeholders cope with future demand. Thus, this study aims to use a systematic literature method to provide data on factors affecting C. ternatea germination. Data on this topic is acquired from the publication in the Google Scholar database. The publications were screened to acquire relevant publications for the review process. This study found that dormancy, pod maturity and seed age are internal factors affecting C. ternatea germination. Meanwhile, external factors such as dormancy alleviation, hormone and PGPR treatment, allelopathic compound, storage, and germination conditions such as storage and substrate temperature also affect the plant species' germination. In conclusion, based on the provided data, C. ternatea germination, like the germination of any other plant species, is affected by internal and external factors.
UPAYA MENINGKATKAN PRESTASI BELAJAR SISWA PADA PENJUMLAHAN DAN PENGURANGAN PECAHAN MELALUI MODEL PEMBELAJARAN CONTEXTUAL TEACHING AND LEARNING (CTL) DI KELAS V SD 01 KOTA PADANGSIDIMPUAN
Authors: Torang Siregar  , Suparni  , Ahmad Nizar Rangkuti  , Lelya Hilda  , Sinar Devi Harahap  , Hasratuddin
Published: June 2024

The general aim of implementing the educational unit level curriculum is to make educational units independent and empowered by granting authority to educational institutions and encouraging schools to make participatory decisions in developing the curriculum. Most elementary school teachers often fail to complete the material satisfactorily. After carrying out initial learning at the author's place of teaching at SD Negeri I Padangsidimpuan City class V, they experienced failure in completing with the following results: There were 14 students who got a score of less than 75 or 66.7% with a KKM of 75. Those who got a score of 75 or more there were 7 students or 33.3% with a KKM of 75. In this lesson the researcher carried out activities in accordance with the lesson implementation plan. At first the students looked active and enthusiastic, but when asked to do practice questions they were still confused about how to do it. After researchers analyzed the results of student work (formative tests) in initial learning, it was found that students did not understand the material. Of the 21 students who got a score above the KKM (75), only 7 students or 33.33%. With an average score of 60.0
Chemical-Biological Activity of Nanodiamond Colloids
Authors: Batsanov* Stepan S , Gavrilkin Sergey M , Dankin Dmitry A , Kurakov Alexander V , Batsanov Andrei S
Published: June 2024

The study of the Nanoscale Diamonds (NDs) and their water suspensions has opened huge opportunities for their technological and biomedical applications. Therefore, the interaction of ND with water is actively studied. However, insufficient attention has been paid to the biochemical behavior of suspensions with low carbon content, despite their great scientific prospects. This work aims to fill this gap in scientific literature.
Method for Calculating the Engineering Design of a Mobile Bioreactor for Organic Waste Processing
Authors: Myradovich* Penjiyev Ahmet , Baymyradovich Babaev Meilis
Published: June 2024

The article discusses the engineering calculation methodology for developing the design of a mobile bioreactor for processing organic waste. The calculations for processing organic waste were based on SNiP, instructions and methods of leading scientists. When calculating the mobile bioreactor, we took into account: the limit of decomposition of fats, proteins, carbohydrates and the formation of biogas with the density of the mixture. A diagram of the phase process of ongoing and sequential decomposition with the maximum possibility of fermentation for an organic mixture with activated sludge over time, under aerobic and anaerobic conditions during waste disposal, is presented. The advantages and disadvantages of dry and wet waste processing methods are analyzed. From the calculations obtained, we can draw the following conclusion: in a bioreactor with a volume of 7.5 liters, in thermophilic mode, and with a volume of 15 liters, in mesophilic mode, approximately 50% of the organic mixture is fermented, and with activated sludge with a wet substrate, about 95%.
Global Health Governance and the Challenge of Holding Power to Account
Authors: McCoy David , Joshi Anuradha , Khosla Rajat , Schaaf Marta , Ely Yamin Alicia
Published: June 2024

While there is much to celebrate about the many institutions, actors, and initiatives that form the global health system, there are also problems with how the system is governed. Some of these relate to inequities and unmanaged conflicts of interest that are rooted in power imbalances and which leave certain actors with excessive and undue influence. By contrast, poorer countries and communities with the biggest stake in the global health system working equitably, effectively, and efficiently have little power by which to hold the system accountable. This intersecting issue of power, accountability, and global health governance is the focus of this Working Paper. The paper is broken into three sections. The first section discusses the meaning of global health governance and the role of accountability within governance structures and systems in general. It describes the current system of global health governance as being nested within a wider system of global political and economic governance, shaped by international relations, globalisation, and the dominance of neoliberal ideas and policies in recent decades. This has seen, among other things, shifts of power from state-based actors and institutions to more distant and less accountable global actors, as well as from democratic and public institutions to private actors and market forces. In doing so, the Working Paper draws particular attention to the power and accountability of powerful private actors and whether they are sufficiently held accountable. The second section unpacks the concept of accountability and describes five elements that are required for accountability to function (standards; data and information; answerability; sanctions; and remedy). It highlights the importance of independence in accountability and the challenges of holding powerful actors accountable. It then presents a three-layered framework to map accountability as a component of good global health governance. The final section concludes by calling for more discussion about power and accountability in global health, while also emphasising the need for rigorous research in identifying and helping correct harmful and unhealthy accountability deficits.
The Effect of Planning, Organizing and Supervision on Principal Leadership (Literature Review of Educational Management)
Authors: Reza Putra Muhammad
Published: June 2024

This study aims to examine the Effect of Planning, Organizing and Supervision on Principal Leadership (Education Management Literature Review). Within the scope of school education, the existence of the principal is the determinant and direction of school policy. The principal must also have the ability to regulate his agency in order to achieve and realize the agency's goals. In this study, researchers used descriptive qualitative methods and library research. By reviewing previous articles that are relevant to this research. The results of this study are: 1) Planning has an effect on the Principal's Leadership, 2) Organizing has an effect on the Principal's Leadership, and 3) Supervision has an effect on the Principal's Leadership.
Work Environment, Work Conflict, and Employee Performance: A Literature Review
Authors: Nourman Adittya Helmi , Rivai Zainal Veithzal , Hakim Azis
Published: June 2024

The aim of this paper is to provide a structured literature review on the constructs of work environment, work conflict, employee performance, and empirical evidence on the relationship between work environment, work conflict, and employee performance in Indonesia context. 24 (twenty four) papers published during 2018-2022 that investigates work environment, work conflict, employee performance, and the relationship between work environment, work conflict, employee performance were reviewed. The results of the literature review regarding the effect of the work environment on employee performance show different results. The majority (83.33%) indicated that the work environment has a positive and significant effect on employee performance, while the remaining (16.67%) indicated that the work environment has insignificant effect on employee performance. The effect of work conflict on employee performance also shows different results. The majority (91.67%) indicated that work conflict has a significant effect on employee performance and the remaining (8.33%) indicated that work conflict has insignificant effect on employee performance. Of all the empirical results showing that work conflict has a significant effect on employee performance, it is obtained evidence that 54.54% has a positive effect, while 45.46% has a negative effect. For this reason, it is recommended that organizations 1) create a work environment (both physical and non-physical) that is conducive to improving employee performance; 2) manage conflicts that occur in the workplace effectively.
Indonesian Politicians From One Stage to Another
Authors: Arrianie Lely
Published: June 2024

After the Reform Era's birth in 1998, following the New Order regime's downfall that had controlled Indonesian politics for 32 years, two shows dominate the Indonesian political stage: freedom and violence. Politicians manage their roles on the front-stage, middle-stage, and backstage with the different political communication styles from those in the New Order era. Today, political communications in the Parliament tend to be more fluid as well as interactional, circular, convergent, and even transactional instead of linear, where political communicators, politicians, activists, professionals, and people deliver their aspirations to the political stage and political journalists in more open political message exchanges. All politicians should be wise in presenting their roles in the political stage shows, and social media that functions as the middle stage for political shows, which they should manage well to align political shows with political stages.
Analysis of the Influence of Load Unbalance on the Neutral Current Power Loss in Substation KP10 PT. PLN (Persero) UP3 Teluk Naga
Authors: Listiawati Dwi , Pawenary  , Apsari Nita Andini
Published: June 2024

The research objective is to analyze the percentage value of load unbalance before and after load balancing and the effect on neutral current losses. The load imbalance that occurs at the KP10 substation is simulated through the ETAP 16.0.0 software. Based on the research results, it was found that there was an imbalance in the load of the KP10 substation in direction B, which experienced the greatest load imbalance with a percentage of 38.76% and in direction A, which experienced a load imbalance of 19.6%. Based on SPLN No. 017 of 2014, the percentage of load imbalance exceeding 25% must be repaired. So that the repair is carried out by equalizing the load by breaking the load from direction B to direction A. After the activity of equalizing the load distribution, a decrease in the percentage of load imbalance is obtained. Majoring A is 8.9% and majoring B is 12,6%. The existence of this load imbalance also causes losses due to neutral currents where before the equalization activities the neutral current losses amounted to 6.99% and after the equalization of 1.06%. A simulation was also carried out where the load imbalance simulation results were obtained with the measurement results having results that were not much different.
Improving Collaboration Ability Through the Jigsaw Type Cooperative Learning Model for Early Age Children 5-6 Years at the Pembina Muara Bulian State Kindergarten, Batanghari Regency, Jambi Province
Authors: Hayati Melija , Hakim Lukman , Hindun
Published: June 2024

This research aims to examine children's cooperative abilities using the jigsaw type cooperative learning model in early childhood at the Pembina Muara Bulian State Kindergarten, Batanghari Regency, Jambi Province. Collaboration referred to in this research is an interaction or relationship between students and teachers or between students and other students in order to achieve learning goals. This type of research is Classroom Action Research (CAR), which is a method where a group of people can organize circumstances in which they can take lessons from their own experiences and make those lessons available to others. Where the teacher is the implementer of learning while the researcher is the observer. This research design uses the Kemmis and Mc Taggart model. This research is in the odd semester 2023/2024, namely in February. The subjects of this research were students at the Pembina Muara Bulian State Kindergarten, consisting of 15 people. The object of research is students' cooperation abilities. Data collection techniques use observation, interviews, questionnaires and documentation. The data was analyzed descriptively and presented in the form of tables and graphs. The results of the research showed that there was an increase in children's cooperation through the pre-cycle with a percentage of 44.44%, an increase of 0.9% in cycle 1 to 45.37% and when carried out in cycle 2 it increased by 17.09% in cycle 2 to 62.46% and when done in cycle 3 it increases by 21.24% in cycle 3 to 83.70%. With the increase in the percentage of children's social development to achieve success of more than 80% in the very well developed category, the process of improving the cooperation of children aged 5-6 years through the jigsaw type cooperative learning model has been completed and achieved the target.
Analyzing The Influences of Cyber-Loafing, Quiet Quitting, and Job Satisfaction On Teacher Performance in Non-Formal Educational Institutions
Authors: Amelia Roza
Published: June 2024

Non-formal educational institutions play a crucial role in enhancing human resource quality. Teacher performance is a key factor determining the effectiveness of the teaching and learning process within these institutions. In the digital age, the emergence of cyber-loafing and quiet quitting phenomena can negatively impact teacher performance. This study aims to analyze the influences of cyber-loafing, quiet quitting, and job satisfaction on teacher performance in non-formal educational institutions, utilizing 42 data samples. This research employs a quantitative method with a survey design. Data was collected from 42 teachers in non-formal educational institutions within the Bekasi area, West Java, Indonesia. Multiple linear regression was used as the data analysis technique.The research findings indicate that cyber-loafing and job satisfaction have positive significant influences on teacher performance, while quiet quitting has a negative significant influence.These findings differ from previous studies suggesting a significant impact of cyber-loafing, quiet quitting, and job satisfaction on teacher performance. This discrepancy might be attributed to factors such as differing sample characteristics, measurement methods, or research contexts.More extensive studies with larger and more diverse samples, alongside more accurate measurement methods, are necessary to confirm these findings.
Targeted synthesis of dipeptides containing derivatives of (S)-phenylalanine and study of their antifungal activity
Authors: Stepanyan Lala , Israyelyan Monika , Hakobyan Heghine , Khachaturyan Nune , Gevorgyan Sona , Hovhannisyan Anahit , Zhamharyan Silva , Sargsyan Tatevik
Published: June 2024

New dipeptides containing derivatives of phenylalanine, N-tert-butoxycarbonyl-(S)-alanyl-(S)-α-methylphenylalanine and N-tert-butoxycarbonyl-(S)-alanyl-(S)-α-methyl-4-fluorophenylalanine, were synthesized. The antifungal activity of initial non-protein amino acids, derivatives of phenylalanine, and synthesized dipeptides was studied by selecting widely spread pathogenic and conditionally pathogenic fungal strains as test fungi: Aspergillus versicolor 12134, A. flavus 10567, A. candidus 10711, Penicillium chrysogenum 8190, P. aurantiogriseum 12053, P. funiculosum 8258, Alternaria alternata 8126, Ulocladium botrytis 12027, and Aureobasidium pullulans 8269. The studies showed that the antifungal activity of (S)-α-methyl-phenylalanine amino acid was pronounced against P. aurantiogriseum 12053 and Ulocladium botrytis 12027 fungal strains when applied at a concentration of 0.177 mg/ml; the dipeptide containing the mentioned amino acid showed a high inhibitory effect on the P. aurantiogriseum 12053 strain, exhibiting the same degree of inhibition at concentrations of 0.232 mg/ml and higher. (S)-α-methyl-4-fluorophenylalanine amino acid most significantly suppressed the growth of P. aurantiogriseum 12053, P. funiculosum 8258, Ulocladium botrytis 12027, and Aureobasidium pullulans 8269 fungal strains when a 0.195 mg/ml solution was used. The growth of the P. aurantiogriseum 12053 strain was inhibited even at a lower concentration of 0.13 mg/ml; the dipeptide containing the amino acid significantly inhibited the growth of the P. aurantiogriseum 12053 strain when applied at a concentration of 0.369 mg/ml.
Gymnostachyum calcicola (Acanthaceae), a new species from limestone karst of Peninsular Malaysia
Authors: Rafidah Abdul Rahman , Ummul Nazrah Abdul Rahman , Ong Poh Teck
Published: June 2024

A new species, Gymnostachyum calcicola Rafidah, sp. nov. (Acanthaceae) is described from limestone karst in Peninsular Malaysia. Characters distinguishing it from related species, colour photographs, botanical illustration and provisional conservation status are provided.
Four new erythroneurine leafhopper species from karst areas in Southwestern China (Hemiptera, Cicadellidae, Typhlocybinae, Erythroneurini)
Authors: Wang Jinqiu , Xu Wenming , Pu Tianyi , Zhang Ni , Song Yuehua
Published: June 2024

Four new erythroneurine leafhopper species, Empoascanara aparaoides Wang & Song, sp. nov., Motaga mengyangensis Wang & Song, sp. nov., Motaga acicularis Wang & Song, sp. nov., and Tautoneura qingxiuensis Wang & Song, sp. nov. from karst areas in Southwestern China, are described and illustrated.
The Opportunity for Educational Innovations and Requirements in Academic System Reform of Medical Schools
Authors: Yoon Bo Young
Published: June 2024

The amendment to the Higher Education Act enforced on February 20, 2024, abolishing the traditional 2-year pre-med and 4-year medical school programs, marks a significant shift in medical education in Korea. The academic system reform is expected to be a driving force for large-scale curriculum revision, presenting an opportunity to introduce new educational innovations not only in curriculum but also in student assessment and support systems. Addressing these challenges requires collaborative efforts among educators, students, and communities to navigate the evolving landscape of medical education effectively. In this regard, I will illustrate the recruitment and development of educators to implement the reform and the collaboration between communities and medical schools to innovate medical education.
Diagnosis and Management of Subclinical Hypothyroidism: The 2023 Clinical Practice Guideline, Korean Thyroid Association
Authors: Chung Hyun-Kyung
Published: June 2024

Subclinical hypothyroidism (SCH) is characterized by elevated serum thyroid-stimulating hormone (TSH) levels and normal free thyroxine levels. The Korean Thyroid Association recently issued guidelines for managing SCH. Based on the Korea National Health and Nutrition Examination Survey (2013-2015), a serum TSH level of 6.8 mIU/L is the reference value for SCH. SCH is classified as mild (TSH 6.8-10.0 mIU/L) or severe (TSH > 10.0 mIU/L), and patients are categorized as adult (age < 70 years) or elderly (age ≥ 70 years). Levothyroxine treatment (LT4-Tx) is not recommended for mild or even severe SCH in elderly patients. Immediate LT4-Tx can be given to adults in most cases, but not to women who are pregnant, patients with progressive disease, or patients with underlying coronary artery disease, heart failure, or dyslipidemia.
Non-carbapenem Drugs for Patients with Bacteremia caused by Extended-Spectrum β-Lactamase-Producing Enterobacteriaceae: Piperacillin-Tazobactam
Authors: Oh Hyunjoo , Lee Seunghee , Kim Misun , Heo Sang Taek , Yoo Jeong Rae
Published: June 2024

Background/Aims: Carbapenems are recommended for treating bacteremia caused by extended-spectrum β-lactamase (ESBL) producing Enterobacteriaceae (ESBL-E). However, this has resulted in a significant rise in the utilization of carbapenems in cases of ESBL-E infection. We evaluated the clinical outcomes of patients with ESBL-E bacteremia treated with non-carbapenem antimicrobials.Methods: We conducted a retrospective case-control study of a cohort of patients with documented ESBL-E bacteremia from January 2021 to December 2021. The patients were divided into two groups according to whether they received non-carbapenem or carbapenem therapy. The rates of treatment failure, 30-day mortality and microbiologic failure, and the durations of hospitalization and of antimicrobial therapy were compared between the two groups. Antimicrobial susceptibility testing and phenotypic identification of ESBL-E were performed using the Vitek 2 system.Results: Of 118 patients with ESBL-E bacteremia, 54 received non-carbapenem drugs (non-carbapenem group [NCG]) and 64 received carbapenems (carbapenem group [CG]). Treatment failure at 30 days occurred in 16.7% of the patients in the NCG and in 18.8% in the CG (p = 0.65). The 30-day mortality rate was 14.8% in the NCG and 17.2% in the CG (p = 0.63). Extra-urinary tract infection and prior antimicrobial therapy within 30 days were risk factors for treatment failure in patients with ESBL-E bacteremia. The clinical outcomes did not differ significantly between the two groups, challenging the prevailing preference for carbapenems in the treatment of ESBL-E bacteremia.Conclusions: Non-carbapenem antimicrobials such as piperacillin/tazobactam are recommended for patients with mild ESBL-E bacteremia in South Korea.
A Rare Case of Acute Pyelonephritis Leading to Bilateral Subcapsular Renal Hematoma: A Case Report
Authors: Park Hae Won , Seo Minsuk , Lee Chung Sik
Published: June 2024

This case underscores the rarity of bilateral subcapsular renal hematoma (SCH) as a complication of acute pyelonephritis, and this is the first reported case in South Korea. SCH can have various underlying causes, including cysts, bleeding tendencies, cancer, vascular diseases and, less commonly, infections. A patient with uncontrolled diabetes mellitus and alcohol dependency presented with weakness. Bilateral SCH from acute pyelonephritis was diagnosed and treated with antibiotics and renal replacement therapy. Despite improved renal function, 30-day bilateral percutaneous drainage was necessary due to a persistent fever and elevated infection markers, resulting in a bloody, pus-like discharge. This case report sheds light on the rare etiology of bilateral SCH as a result of acute pyelonephritis. It serves as a reminder of the critical importance of timely intervention, to prevent deteriorating outcomes.
L’alignement stratégique de la RSE : la conception d’un Sustainability Balanced Scorecard pour une société à mission
Authors: Chéhimi Mélinda , Naro Gérald
Published: June 2024

L’article porte sur le Sustainability Balanced Scorecard (SBSC), qui inclut les problématiques de soutenabilité et de Responsabilité Sociale des Entreprises (RSE) dans son modèle de performance. Fondée sur un cas unique, réalisé à partir d’une recherche intervention menée au sein d’une société à mission (SAM), l’étude porte sur la conception collective de la carte stratégique d’un SBSC. Au-delà du cas spécifique d’une SAM, nos observations supportent l’idée selon laquelle le SBSC peut effectivement constituer un outil pertinent pour l’alignement stratégique de la RSE, mais sous condition d’une approche interactive (Simons 1995) dans le cadre d’une stratégie ouverte (Whittington 1996).
Fondation et évolution de l’Institut de Psychologie de Paris
Authors: Nicolas Serge
Published: June 2024

Avant la fondation de l’Institut de psychologie de Paris, il existait déjà au tournant du siècle un enseignement de la psychologie assuré dans la capitale par de grandes figures fondatrices de la psychologie française, notamment par Théodule Ribot et Pierre Janet. Mais aucune formation spécifique ni aucun diplôme de psychologie n’était délivré aux étudiants fréquentant l’enseignement supérieur français. Il faudra la détermination d’Henri Piéron et de quelques philosophes ouverts à la science nouvelle, notamment Henri Delacroix et Georges Dumas, pour que soit fondé en 1920 l’Institut de psychologie de Paris qui va devenir le lieu emblématique de diffusion de la psychologie scientifique en France, avant que ne soit créée la licence de psychologie en 1947. L’article présente dans ses grandes lignes l’histoire de la fondation de l’Institut de Psychologie de Paris et son développement jusque dans les années 1960.
Vision et oculomotricité
Authors: Doré-Mazars Karine , Vergilino-Perez Dorine
Published: June 2024

L’étude des mouvements oculaires passionne les chercheurs depuis de nombreuses années. Nous explorons notre monde visuel et interagissons avec lui grâce à une alternance de saccades -qui déplacent le regard d’un point du champ visuel à un autre- et de fixations -pendant lesquelles l’information est traitée-. Caractériser le décours temporel et spatial de l’exploration oculaire permet ainsi de mieux comprendre les liens entre perception, action et cognition. Objets d’étude en tant que tels ou outils d’investigation de la cognition, les mouvements oculaires ont de tout temps été au cœur de travaux de recherche fondamentale, clinique ou appliquée. Cela est particulièrement le cas au sein de l’Institut de Psychologie où les recherches sur l’oculomotricité n’ont jamais cessé depuis les premiers travaux réalisés en psychologie expérimentale dans les années soixante jusqu’à aujourd’hui. La célébration du centenaire de l’Institut est l’occasion de mettre à l’honneur cette longue tradition d’études sur l’oculomotricité.
Régulation et menaces sociales
Authors: Sanitioso Bo
Published: June 2024

Après un bref regard historique sur le Laboratoire de Psychologie Sociale à l’Institut de Psychologie, Université Paris Cité, l’article présente nos recherches sur la menace sociale. Ces recherches abordent la menace et sa régulation aux niveaux individuel et collectif. En effet, une menace peut être perçue par les individus comme les ciblant personnellement, par exemple leur image positive du soi. Elle peut aussi être perçue comme ciblant les individus en tant que membres d’un groupe. Vis-à-vis de ces derniers, nos travaux portent entre autres sur la menace du stéréotype et sur la justification du système. En fonction de leur niveau, la régulation des menaces peut amener les individus à mobiliser des stratégies différentes et des ressources distinctes. Le rappel sélectif et la construction du soi possible sont des stratégies étudiées au niveau de la menace individuelle, tandis que les contacts intergroupes et l’activation des idéologies sont abordés au niveau collectif.
Le conseil constitutionnel et l’interruption volontaire de grossesse
Authors: Charité Maxime
Published: June 2024

Depuis 1975, année de l’adoption de la loi Veil et de la « grande décision » du Conseil constitutionnel relative, ce dernier garantit le droit à l’interruption volontaire de grossesse tel que le développe le législateur. Cet état de la jurisprudence n’empêche toutefois pas de questionner la constitutionnalisation de ce droit, qui se justifie moins juridiquement que symboliquement.
Du coup du bouchon au rhizome ou de l’écologie à l’écologie sociale
Authors: Midrez Pascal
Published: June 2024

Comme la plupart des secteurs d’activités, le champ du travail social est désormais traversé par la question écologique. Face à l’ampleur des défis qui se dressent sur le chemin de l’humanité et compte tenu de l’usage intempestif des termes liés au développement durable, quelle forme d’écologie peut-elle faire sens en matière d’intervention sociale ?
Le travail social à l’épreuve des écologistes. Proposition d’une reconfiguration du secteur
Authors: Durand Lucie
Published: June 2024

Aujourd’hui, parmi ses missions, le travail social détient celle de l’accompagnement au changement social. Ce dernier se manifeste, notamment, au travers des mobilisations collectives écologiques. Sur le territoire rural étudié au cours d’une recherche, un conflit écologique se révèle dépassé par la violence ce qui produit entre autres, omerta et clivage. L’objectif de l’article est de repérer la place du travail social dans ce contexte. Les compétences de l’ingénierie sociale sont mises à l’œuvre en soutien à la reconfiguration du travail social sur un territoire en conflit écologique. Militants, acteurs sociaux, acteurs politiques et institutionnels apparaissent faibles, enclavés et/ou empêchés pour diverses raisons qui sont explorées au cours de l’article.
La fabrication du réel
Authors: Étienne Pierre
Published: June 2024

Comment écologiser le Travail social ? Comment socialiser l’écologie dans la visée d’une fabrication alternative du réel en s’appuyant sur une recherche ayant identifié une typologie de six logiques d’action ? Après avoir exemplifié la caractéristique du contexte contemporain comme celui de l’urgence écologique dans le cadre du nécrolibéralisme , retour sur les concepts de «  prepardness  » et de «  worst case scenario » (se préparer au pire) afin de suggérer une alternative à ceux-ci : celle de réparer le meilleur. Comment envisager le Travail social depuis sa formation en intégrant les principes de l’écologie sociale de Murray Boockchin ?
Petits gestes versus grande politique ? Quand un squat pratique l’écologie sociale
Authors: Babou Igor
Published: June 2024

La question que pose cet article est celle des leviers d’action non étatiques qui permettraient de porter le projet d’une écologie sociale. On y répond sur la base de l’ethnographie d’une mobilisation écologiste réalisée entre 2018 et 2021 dans un squat en banlieue parisienne. Après une présentation de l’écologie sociale, puis des relations entre écologie, milieu urbain et squats, des réflexions relevant de l’écologie politique seront tirées de cette ethnographie.
Quel travail social et quelle écologie ? Revenir sur la division nature/culture pour une écologie comme capacité à nouer des liens
Authors: Gervais Mathieu
Published: June 2024

Cet article développe l’hypothèse selon laquelle la manière de définir le travail social et celle de définir l’écologie sont liées. En s’appuyant sur les théories de l’écologie et sur l’exemple concret du projet En Passant par les Calanques, il souligne l’importance de partir de l’expérience des personnes pour interroger collectivement les catégories de culture et de nature. Le rapprochement entre travail social et écologie devient alors libérateur.
Une transition énergétique à double vitesse ? Des inégalités de contribution qui renouvellent des lignes de partage dans la ville
Authors: Christen Guillaume
Published: June 2024

La possibilité d’un agir en faveur de la cause écologique est fréquemment problématisée autour d’une écologie du geste responsable qui place les pratiques environnementales sous le sceau de la conscience individuelle. Dès lors, l’implication citoyenne devient un élément structurant des politiques publiques en matière de transition énergétique où les modalités de la participation s’appuient essentiellement sur la figure de « l’homo écologicus » (Comby, 2013). Or, la place accordée aux habitants et les possibilités de contribution à un bien commun que serait l’énergie verte diffèrent selon que l’on s’adresse à des quartiers populaires ou résidentiels. Ces modalités différenciées de la participation habitante sont susceptibles d’induire des formes d’inégalités écologiques, renouvelant des lignes de partage dans la ville.
Comment tirer le meilleur parti des données ?
Authors: Lacroux Alain
Published: June 2024

La GRH est significativement impactée par la révolution des « big data » : l’accumulation de masses de données importantes sur les salariés apparaît aujourd’hui dans le discours de certains observateurs comme une condition nécessaire et suffisante pour la construction de modèles prédictifs de comportements complexes au travail comme l’absentéisme ou la performance en poste. En réalité, les enjeux majeurs ne tournent pas autour de la quantité des données, mais concernent plutôt les méthodologies permettant la transformation de ces données en connaissance, si possible actionnable. Les réflexions sur les méthodes applicables pour relever ce défi sont relativement récentes, et mentionnent régulièrement un renouveau de l’empirisme dans un « quatrième paradigme » fondé sur l’exploitation intensive et « agnostique » de masses de données en vue de faire émerger des connaissances nouvelles, selon une logique purement inductive. Sans adopter ce point de vue spéculatif, force est de constater que les approches inductives basées sur les données (data driven) demeurent rares dans les études quantitatives en GRH. Il existe pourtant des méthodes bien établies, notamment dans le domaine de la fouille de données (data mining), qui reposent sur des approches inductives. Ce domaine de l’analyse quantitative à visée inductive demeure encore assez peu exploré en GRH (à l’exception des analyses typologiques). L’objectif de cet article est tout d’abord de dresser un panorama des méthodes mobilisables pour des recherches en GRH, avant de proposer une illustration empirique qui consiste en une recherche exploratoire combinant une analyse en profils latents et une exploration des profils obtenus par des modèles graphiques gaussiens.