bluuebunny/crossref_metadata_2025 huggingface dataset:
Aproximación al Concepto de “Competencias Emprendedoras”: Valor Social e Implicaciones Educativas
Authors: Martínez Francisco Miguel , Carmona Gabriel
Published: September 2023

En el marco del llamado paradigma de enseñanza para el desarrollo de competencias, indagamos acerca del origen y significado actual del término, exponemos sus características y tipología, así como su rápida extensión a distintos ámbitos como el productivo-empresarial, el educativo y el social. Posteriormente, nos centramos en las “competencias emprendedoras” como nueva tipología, que comparte aspectos característicos del tradicional “enfoque por competencias” y de las “competencias clave”. A modo de conclusión, defendemos que la educación, más allá de la formación, es un instrumento privilegiado por cuanto persigue la construcción de un ideal humano mediante estrategias, medios, recursos, etc., con los que generar la adquisición de valores, creencias y conocimientos, necesarios para promover el desarrollo de competencias que den lugar a una necesaria cultura emprendedora. Descriptores: Competencias, cultura emprendedora, educación, desarrollo socioeconómico. Approaching the Concept of “Entrepreneurial Skills”: Social Value and Educational ImplicationsIn the framework of the skills-development teaching paradigm, we explore the origin and current meaning of the term, setting out its characteristics and typology and its rapid spread in various different ambits, such as production and business, education and socioeconomics. We then focus on “entrepreneurial skills” as a new typology sharing certain characteristics with the traditional “skills approach” and “key skills”. In conclusion, we defend the idea that education, beyond training, is a privileged instrument inasmuch as it seeks to build a human ideal through strategies, ways and means, resources, etc. to generate the acquisition of the values, beliefs and knowledge in order to foster the development of skills and give rise to a necessary entrepreneurial culture.Keywords: Skills, entrepreneurial culture, education, socioeconomic development.
Potret Miskonsepsi Siswa SMA pada Materi Komponen Penyusun dan Interaksi dalam Ekosistem
Authors: Triana Bella Maya
Published: September 2023

Kemampuan memahami materi pelajaran yang lebih tinggi merupakan sakah satu penunjang dalam terwujudnya proses pembelajaran. Tujuan penelitian adalah guna untuk mengetahui gambaran miskonsepsi yang dialami siswa pada materi komponen penyusun dan interaksi dalam ekosistem. Metode penelitian ini menggunakan jenis penelitian studi kasus melalui pendekatan deskriptif kualitatif. Subjek dalam penelitian ini merupakan siswa Sekolah Menengah Atas (SMA). Sampel yang digunakan dalam penelitian ini adalah purposive sampling. Instrument pengumpulan data dengan instrumen three tier diagnostic test. Hasil penelitian menunjukkan bahwa miskonsepsi siswa pada materi komponen penyusun dan interaksi dalam ekosistem terdapat beberapa kategori paham konsep, tidak paham konsep, miskonsepsi (false positive), dan miskonsepsi (false negative). Pemahaman siswa Sekolah Menengah Atas (SMA) memiliki persentase kategori miskonsepsi yang dialami siswa memperoleh hasil yang berbeda-beda. miskonsepsi murni memiliki rata-rata sebesar 26,66%, false negative sebesar 23,99%, dan false positive sebesar 10,66%. Rata-rata keseluruhan miskonsepsi sebesar 63,32. Rata-rata pemahaman siswa dalam materi komponen penyusun dan interaksi dalam ekosistem pada kategori paham konsep persentase sebesar 27,33%, miskonsepsi sebesar 63,32%, dan tidak paham konsep sebesar 11,33%. Miskonsepsi dalam materi konsep ini memiliki persentase sebesar 63,32% tergolong kategori tingkat tinggi. Beberapa faktor dapat mempengaruhi terjadinya miskonsepsi yang dialami siswa seperti guru, model pembelajaran, dan bahan ajar. Oleh sebab itu, diperlukan adanya penunjang pemahaman siswa supaya tidak terjadi miskonsepsi yang dapat menghambat keberhasilan siswa dalam proses belajar.
Practicum-Based Learning to Improve Critical Thinking Ability and Student Learning Outcome on Cell Metabolism Material
Authors: Julita Julita , Sunandar Ari , Hanum Hanum Mukti
Published: September 2023

Practicum in the laboratory makes students more engaged with the learning process and improves communication with the teacher. The aims of this research are to determine the effect of practicum-based learning to improve critical thinking skills and learning outcomes of students on cell metabolism material. This research includes a Pre-Experimental with One Group Pretest-Posttest Design. The sample was determined using simple random sampling techniques. Pre-tests and post-tests were done to collect data. Data analysis of learning outcomes and critical thinking skills using gain value analysis. The results of this study showed the student learning outcomes value was 24 and the value of students' critical thinking was 7. The effect size value of student learning outcomes obtained 2.3 points, which was included in the very high category and the effect size value for students' critical thinking was 1.4 points, which was included in the high category. We can conclude that practicum-based learning influences students' critical thinking and improves students' learning outcomes on metabolic matter.Keywords: cell metabolism, critical thinking, learning outcomes, practicum-based learning.
SURVEILLANCE AND SECURITY MODELS BASED ON THE ARDUINO UNO INTERFACE
Authors: Zakariashvili M. Z. , Sivsivadze G. , Chidrashvili M. , Khechoshvili L.
Published: September 2023

The issue demonstrated in the article covers construction of   surveillance and security systems on Arduino UNO platform Technological and Software aspect which are based on Quality Semiconductor Sensor-MQ135; PIR Motion Sensor and use of blocking peculiarities.
The project model integration process in both a virtual and physical context is described in detail and analyzed in the paper. The following are specifically used: An Arduino UNO microcontroller board, the Arduino Software IDE (Integrated Development Environment), a local code editor on the PC, and the virtual online platform tinkercad.com. The work is supplemented by pertinent electronic diagrams, schemes, software code, descriptions of fundamental functionalities, links to virtual project simulation, real-world application, and links to video recordings of the experiment in order to demonstrate the project model's smooth operation.
Principles for diagnosing heart failure with preserved ejection fraction
Authors: Shirokov N. E. , Yaroslavskaya E. I. , Krinochkin D. V. , Musikhina N. A. , Gizatulina T. P. , Enina T. N. , Petelina T. I. , Soldatova A. M. , Samoilova E. P. , Pogorelov N. O. , Gapon L. I.
Published: September 2023

Low-grade systemic inflammation, myocardial stress, and extracellular matrix fibrosis lead to heart failure with preserved ejection fraction (HFpEF). The HFA-PEFF diagnostic algorithm and the H2FPEF score are recommended for detecting HFpEF. Their low compliance is the reason for improving the methods for diagnosing HFpEF. Modern paraclinical diagnostics of HFpEF includes an assessment of the left ventricular filling pressure during diastolic stress test. Phase analysis of left atrial strain during resting echocardiography may be promising to conclude an increase in mean left atrial pressure. Research interest is growing in relation to biomarkers involved in the regulation of collagen synthesis. Together, paraclinical diagnostics help to characterize sequential morphofunctional cardiac remodeling, increasing the possibility of HFpEF detection.
Efficacy and safety of acetazolamide in patients with NYHA class II-IV decompensated heart failure: protocol of an open-label prospective randomized multicenter study (ORION-A)
Authors: Rubanenko O. A. , Rubanenko A. O. , Villevalde S. V. , Duplyakov D. V.
Published: September 2023

Aim. To study the efficacy and safety of acetazolamide administered orally to patients with decompensated heart failure (HF) at the hospital stage within 72 hours from admission, compared with standard therapy.

Material and methods. This open-label, prospective, randomized, multicenter study is planned to include 400 patients urgently admitted to hospital with NYHA class II-IV decompensated HF: 200 patients each in the standard therapy group and additional acetazolamide (tablets) group. The primary endpoint includes the number of patients who achieved compensation in accordance with the criteria for diuretic therapy discontinuation. There are secondary endpoints: increase in urine output in the first 72 hours of hospitalization (since randomization), weight loss, 24-hour natriuresis, length of stay in hospital, length of stay in the intensive care unit, 90-day any-cause death, 90-day cardiovascular death, 90-day death due to chronic HF decompensation or acute decompensated HF, the number of pleuro- and pericardiocentesis episodes during the hospitalization, scale for clinical condition assessment of HF patient (SHOKS) at discharge from the hospital, 6-minute walk test at discharge from the hospital. The planned follow-up duration is a hospital period with an assessment of the clinical picture and laboratory parameters. Telemedicine contact with patients is carried out after 14, 30 and 90 days using a structured questionnaire.

Conclusion. Analysis of clinical, laboratory and echocardiographic parameters of patients using acetazolamide tablets will make it possible to determine the criteria for the effectiveness of diuretic therapy in patients with decompensated HF in the short and long term.
Perfect storm: a clinical case of multisite (brain, coronary, renal and spleen) embolism in patient with atrial fibrillation
Authors: Novitsky N. I. , Baglikov A. N. , Soloveva A. E. , Kruchinova S. V. , Kosmacheva E. D. , Villevalde S. V.
Published: September 2023

Nonvalvular atrial fibrillation (AF) is the most common cause of arterial thromboembolism, especially of ischemic stroke. Other than stroke AF-associated embolic events are usually underestimated but at least similarly important. We present a rare case of simultaneous multiple embolism in a 70 years old women with permanent AF.
Pulse oximetry methods: opportunities and limitations
Authors: Garanin A. A. , Dyachkov V. A. , Rubanenko A. O. , Reprintseva O. A. , Duplyakov D. V.
Published: September 2023

The aim of this review was to evaluate the current literature on various methods of pulse oximetry, their advantages and disadvantages. Modern pulse oximetry methods generally correlate well with invasive saturation monitoring, which makes it possible to be widely used in clinical practice. At the same time, in order to improve the accuracy of saturation measurements, existing limitations of various pulse oximetry methods should be taken into account. The emergence and introduction into clinical practice of reflectance pulse oximetry can largely compensate for the limitations of traditional transmission pulse oximetry regarding peripheral hypoperfusion, low response time, and features of patient's nails. In the event of special situations when pulse oximetry may not be accurate enough (carbon monoxide poisoning, methemoglobinemia, severe anemia, severe tricuspid insufficiency, etc.), a thorough clinical assessment of the patient is recommen ded, as well as invasive saturation monitoring.
Variety of clinical manifestations of hypertriglyceridemia: a case series
Authors: Zafiraki V. K. , Namitokov A. M. , Gilevich I. V. , Gradovskaya M. V. , Malyarevskaya O. V. , Karabakhtsieva K. V.
Published: September 2023

To date, there is no doubt about the participation of triglyceride-rich lipoproteins in atherogenesis. However, the variety of clinical manifestations of hypertriglyceridemia does not always allow timely recognition of patients with high cardiovascular risk for the timely initiation of therapy. The article presents 3 following cases: patient with isolated hypertriglyceridemia without clinical manifestations and with a good response to treatment, a patient with skin manifestations of hypertriglyceridemia and a patient with severe multifocal atherosclerosis, diabetes and recurrent pancreatitis. References are also provided for each case.
Network Pharmacology to Reveal the Molecular Mechanisms of Rutaceous Plant-derived Limonin Ameliorating Non-alcoholic Steatohepatitis
Authors: Wang Wei , Yang Li , Hu Minjie , Yang Yonglin , Ma Qiang , Chen Jiayu
Published: September 2023

Background: Limonin shows promise in alleviating non-alcoholic fatty liver disease. We investigated the mechanisms of limonin against non-alcoholic steatohepatitis (NASH) using network pharmacology and molecular docking.

Methods: Public databases provided NASH- and limonin-associated targets. VennDiagram identified potential limonin targets for NASH. Enrichment analysis explored the limonin–NASH relationship. PPI network analysis, CytoHubba models, and bioinformatics identified hub genes for NASH treatment. Molecular docking assessed limonin's binding ability to hub targets.

Results: We found 37 potential limonin targets in NASH, involved in oxidative stress, inflammation, and signaling pathways. PPI network analysis revealed seven hub genes (STAT3, NFKBIA, MTOR, TLR4, CASP8, PTGS2, NFKB1) as NASH treatment targets. Molecular docking confirmed limonin's binding to STAT3, CASP8, and PTGS2. Animal experiments on high-fat diet mice showed limonin reduced hepatic steatosis, lipid accumulation, and expression of p-STAT3/STAT3, CASP8, and PTGS2.

Conclusion: Limonin's therapeutic effects in NASH may stem from its antioxidant and anti-inflammatory properties. STAT3, CASP8, and PTGS2 are potential key targets for NASH treatment, warranting further investigation.
EFFICIENCY DETERMINATION OF SOLAR CHIMNEY POWER PLANT RETROFITTED WITH NOVEL FINNED COLLECTOR UNDER REAL-TIME SOLAR IRRADIANCE
Authors: Hasan Ibrahim Shikh , Pazarlıoğlu Hayati Kadir , Arslan Kamil , Ekiciler Recep
Published: September 2023

This paper discusses the three-dimensional numerical study of a new finned collector integrated into the solar chimney
power plant. Manzanares pilot's details, which are tower height 194.6 m, rooftop height 1.85 m, rooftop diameter 244
m, tower diameter 10.16 m, and pilot mean temperature 20°C with air speed 15 m/s, are implemented in this work to check the suitability of the finned collector as a way of improvement. In order to assess the unique idea, a parametric study is done with different number of fins: 46, 33, and 25; different fin widths: 0.5, 0.25, and 0.1 m, and different fin heights: 1.2, 0.925, and 0.6 m. Therefore, optimal outputs could be obtained by the novel rooftop that is proposed in this study, where the efficient case is specified dimensionally by 46 fins, a fin width of 0.1 m, and a fin height of 1.2 m, which gives 1.674% as the station performance, 700.597 kW as the resulted power of the plant, 1790.3 as the Nusselt number, and 1.96E+14 as the Rayleigh number.
MULTIPHASE FLOW OF NEWTONIAN FLUID SANDWICHED BETWEEN MICROPOLAR AND COUPLE STRESS FLUIDS THROUGH A COMPOSITE POROUS CHANNEL
Authors: Patel Pawan Kumar , Deo Satya , Maurya Pankaj Kumar
Published: September 2023

The present study is concerned with the flow of a Newtonian fluid through a composite rectangular porous channel
sandwiched between micropolar and couple stress fluids. The horizontal composite porous channel is divided into three
porous channels of uniform width, and flow is induced due to a constant pressure gradient. The Brinkman equation is
used for the fluid motion in middle porous channel, while governing equations of micropolar and couple stress fluids
are used to describe the motion within the lower and upper porous channels, respectively. Expressions of linear velocity, microrotations, stresses (shear and couple) and flow rate are obtained analytically. Continuity of velocity, continuity of tangential stresses, no slip, no spin, and no couple stress conditions are used at interfaces and outer surfaces of the channel. Effects of permeability parameters, micropolar parameter, and pressure gradient on the flow rate and fluid velocity are discussed and presented graphically. Numerical values of flow rate (Q) for permeability, micropolar parameter, and pressure gradient are calculated and presented in tabular forms. MSC (2020): 76A05; 76S05; 76D05; 35C05.
The Rise of Procedural Legitimacy of the EU under the Juncker Commission: The Impact of the Better Regulation Agenda
Authors: Deligiaouri Anastasia , Papadopoulos Ioannis , Kyriakides Alexandros
Published: September 2023

The aim of this paper is to examine if, and to what extent, the EU governance system corresponds to the principles and demands of procedural legitimacy. We analyze procedural legitimacy as this is developed in the work of Lon Fuller and Robert Summers, and we conceptualize and examine legitimacy at the EU level through the three criteria of input, output, and throughput. We use these criteria to analyze the basic rationale and components of the 2015 Better Regulation Agenda of the Juncker Commission, arguing that it has enhanced citizens’ involvement in the policy-making process of the EU and has led to increasing participatory practices, by strengthening throughput legitimacy. However, there are still shortcomings in establishing a deliberative mode of public engagement. Throughput seems to have a considerably increased importance in the EU’s quest for legitimacy, although there is still room for improvement.
Özel Öğrenme Güçlüğü Olan ve Olmayan Ortaokul Öğrencilerinin Akıcı Okuma ve Okuduğunu Anlama Performanslarının İncelenmesi
Authors: ARACI Nefize , MELEKOĞLU Macid Ayhan
Published: September 2023

Bu araştırmada, özel öğrenme güçlüğü (ÖÖG) olan ve olmayan ortaokul öğrencilerinin akıcı okuma ve okuduğunu anlama becerilerindeki performanslarının yanı sıra genel okuma performanslarının karşılaştırılarak okuduğunu anlama becerileri ile akıcı okuma becerileri arasındaki ilişkinin araştırılması amaçlanmaktadır. Tarama yöntemi ve ilişkisel yöntemin kullanıldığı araştırmanın çalışma grubunu Eskişehir ili merkez ilçelerinde bulunan resmî ortaokullarda eğitimlerini sürdüren ve ölçüt örnekleme yöntemi kullanılarak belirlenmiş olan 86 ÖÖG olan ve olmayan öğrenci oluşturmaktadır. Araştırmada veri toplama aracı olarak Sesli Okuma Becerisi ve Okuduğunu Anlama Testi-II (SOBAT®-II) kullanılmıştır. Öğrencilerin okuma performanslarının karşılaştırılmasında parametrik testlerden Bağımsız Örneklemler t Testi kullanılırken okuduğunu anlama becerileri ile akıcı okuma becerileri arasındaki ilişkinin araştırılmasında Pearson Momentler Korelasyon Katsayısı kullanılmıştır. Araştırma sonucunda, ÖÖG olan ortaokul öğrencilerinin akıcı okuma, okuduğunu anlama ve genel okuma performanslarının ÖÖG olmayan akranlarına göre istatistiksel olarak anlamlı düzeyde daha düşük olduğu ve ÖÖG olan ortaokul öğrencilerinin akıcı okuma ve okuduğunu anlama performansları arasında yüksek düzeyde ve istatistiksel olarak anlamlı bir ilişki olduğu ortaya koyulmuştur. ÖÖG olmayan ortaokul öğrencilerinin akıcı okuma ve okuduğunu anlama performansları arasında orta düzeyde ve istatistiksel olarak anlamlı bir ilişki olduğu ortaya koyulmuştur. ÖÖG olan ortaokul öğrencileri için hazırlanacak akıcı okuma odaklı eğitsel müdahale programları, öğrencilerin okuduğunu anlama becerilerini de destekleyerek akademik performanslarının geliştirilmesine katkı sağlayabilecektir.
Brain Imaging and neurostimulation in health and disorders: status report
Authors: Baptista Abrahão Fontes , Casali Adenauer Girardi , Oda Adriana Leico , Okano Alexandre Hideki , Moreira Alexandre , Santos Ana Lúcia Yaeko da Silva , Fernandes Ana Mércia , Fontana Ana Paula , Brunoni André , Fonseca André , Gosling Artur Padão , Boffino Catarina Costa , Tanaka Clarice , De Oliveira Claudia Eunice Neves , Caparelli-Dáquer Egas , De Angelis Elisabete Carrara , Rodrigues Erika de Carvalho , Fraga Francisco , Hazime Fuad Ahmad , Santana Jamille Evelyn , Sato João Ricardo , Da Silva Josie Resende Torres , Goulardins Juliana Barbosa , Valente Julie Azevedo Araújo , Monte-Silva Katia Karina , Sá Katia Nunes , Valiengo Leandro , Trambaiolli Lucas Remoaldo , Maia Maércio , Da Silva Marcelo Lourenço , Santana Marcus Vinícius , Carthery-Goulart Maria Teresa , Muszkat Mauro , Lee Michael , Parizotto Nivaldo Antonio , Montoya Pedro , Baptista Rachel Fontes , Duarte-Moreira Rafael Jardim , Brito Rodrigo de Mattos , De Oliveira Rogério Adas Ayres , Cury Rubens , Shinjo Samuel Katsuyuki , Lopes Tiago da Silva , Zana Yossi
Published: September 2023

INTRODUCTION: Despite being considered least important for clinical practice in the pyramid of evidence for recommendations, sometimes scientists' expert opinions could help to better understand the summarization of updated publications. OBJECTIVE: To provide a major summarized update about brain imaging and stimulation of the nervous system in health and disease. METHODS: Comprehensive review developed by experts in each subarea of knowledge in neuroimaging and non-invasive stimulation of the nervous system. A team of researchers and clinic experts was invited to present an update on their area of expertise. RESULTS: In basics on brain imaging techniques, we approach general and quantitative electroencephalography, functional magnetic resonance imaging, functional near-infrared spectroscopy, and experimental paradigms in brain imaging studies. Were included associations between transcranial magnetic stimulation and electromyography, electroencephalography, and functional near-infrared stimulation to evaluate brain activity. Furthermore, we showed several actualized central and peripheral neuromodulation techniques. And finally, we presented different clinical and performance uses of non-invasive neuromodulation. CONCLUSION: To our knowledge, this is a major summarized and concentrated update about brain imaging and stimulation that can benefit neuroscience researchers and clinicians from different levels of experience.
Clinical possibilities of flow cytometry in hodgkin’s lymphoma
Authors: Abbasbeyli F. M. , Fedenko A. A. , Zeynalova P. A. , Zibirov R. F. , Grinevich V. N. , Mushkarina T. Yu. , Melnikova A. A. , Vernyuk M. A. , Grivtsova L. Yu.
Published: September 2023

Hodgkin’s lymphoma (HL) is a unique lymphoma of b-cell origin, the tumor cells of which have lost the expression of main b-cell antigens. The standard immunophenotype of the tumor substrate, according to immunohistochemical studies, is characterized by the expression of such markers as CD15, CD30 and PAX-5, while tumor cells have a negative expression of CD3, CD19 and in most cases also CD20 and CD45 (or express this antigen rather weakly). The knowledge gained in recent years has increased the effectiveness of diagnosis, prognosis and treatment of LH. Flow cytometry, as a method of immunophenotyping in classical LH, was practically not used due to the difficulty of distinguishing single reed–sternberg–berezovsky tumor cells (RSB) and the tumor microenvironment (reactive background), which is very rich in cellular elements and is represented by T cells, B cells, eosinophils, histiocytes and plasma cells. However, in the recent past, several studies have successfully attempted to identify rsb cells using multiparameter flow cytometry during aspiration with a thin needle or biopsy of lymph node tissue to confirm or supplement immunohistochemical staining during primary diagnosis. Taking into account the very characteristic immunophenotype of RSB cells, the flow cytometry may become an additional diagnostic method of classical LH in the future. In this review, we summarize the data on the possibility of using the flow cytometry as an additional clinical diagnostic option in the primary diagnosis of classical LH.
Evaluation of the quality of neck dissection in patients with oral cavity squamous cell carcinoma
Authors: Fatkullin D. M. , Guz A. O. , Zaharov A. C. , Garev A. V. , Sokolova M. I.
Published: September 2023

Oral cavity squamous cell carcinoma is one of the leading localizations in the structure of head and neck cancers in the Russian federation and in the world. Neck metastases are the key criterion which influence to survival, recurrence, and distant metastases in patients with oral squamous cell carcinoma. Neck dissection is a main step in the surgical treatment of oral squamous cell carcinoma. This literature review analyzes data on possible methods for assessing the quality of neck dissection in squamous cell carcinoma of the oral cavity. Evaluation criteria can be conditionally divided into prognostic (lymph node extracapsular extension, the size of the largest neck metastasis, lymph node yield, lymph node ratio, metastasis topography) and qualitative (lymph node yield, lymph node ratio). Nowadays, there are some prognostic factors of surgical specimen after neck dissection which we use in clinical practice except for lymph node yield, lymph node ratio. This paper analyzes the criteria for an objective assessment of the quality of the operation “neck dissection”. The clinical and prognostic significance of these parametrs is considered.
Review of clinical cases of internal organ metastases into the skin of the head and neck
Authors: Kretova K. A. , Nazarko O. S. , Kopeikina E. V. , Goncharova O. G. , Obukhova D. A. , Morozov D. V. , Sergeeva S. V. , Sidorov S. V. , Shevchenko S. P.
Published: September 2023

Metastases of malignant tumors of the internal organs into the skin rarely occur, on average in 1–10 % of cases. They can be the first manifestation of malignant process in the absence of signs of the main disease or show progression of confirmed cancer. The article presents clinical cases of metastases of renal cell carcinoma and adenocarcinoma into the skin of the head and neck which currently is rare. Skin metastases are variable in their clinical manifestation. In the presented cases, resection of the lesions was required as symptomatic treatment.
REVIEW OF THE CURRENT EVIDENCE ON THE PHARMACOLOGICAL THERAPY OF EPILEPSY
Authors: Aguiar Lucas , Fernandes Mariz Pedro , Barros Gonçalves Cunha Cláudia
Published: September 2023

A epilepsia é um distúrbio neurológico comum que afeta cerca de 50 milhões de pessoas, mas se tratada adequadamente, os pacientes podem obter remissão a longo prazo. No entanto, a escolha do tratamento adequado ainda é um desafio, pois muitos medicamentos antiepiléticos estão disponíveis e as respostas dos pacientes a esses medicamentos são variáveis. Nosso objetivo é comparar vários estudos sobre monoterapia e terapia combinada para dar uma melhor perspectiva ao profissional médico sobre as opções disponíveis até esta data para o tratamento farmacológico da epilepsia. Esta é uma revisão bibliográfica baseada no banco de dados Pubmed. A pesquisa feita foi "epilepsia" E "tratamento" E "clínico", e os filtros utilizados foram "meta-análise" e 2019-2020 para o período de publicação. De acordo com os resultados expressos por todas as revisões sistemáticas e meta-análises consideradas neste estudo, fica claro que existe uma grande heterogeneidade e nenhum consenso sobre as melhores formas de tratamento clínico dos vários tipos de epilepsia. As evidências científicas apresentadas nos estudos têm baixa relevância estatística e prejudicam a escolha de um tratamento com baixo risco para o paciente e desempenho satisfatório. Estudos clínicos mais randomizados são necessários para a avaliação comparativa de medicamentos isolados, incluindo uma amostra populacional expressiva. Só então será possível chegar a conclusões mais assertivas.
ORIENTAÇÕES SOBRE O PARTO NO PRÉ-NATAL E A INFLUÊNCIA NO TIPO DE PARTO PRATICADO
Authors: Dias Ernandes Gonçalves , Souza Luziana de Freitas , Freitas Vanessa de Oliveira Custódio , Campos Lyliane Martins , Caldeira Maiza Barbosa
Published: September 2023

O pré-natal é uma estratégia de cuidado onde as gestantes recebem orientações sobre os tipos de parto. Objetivou-se investigar as orientações sobre as vias de parto no pré-natal e os fatores que influenciaram no tipo de parto praticado por mulheres de um município do norte de Minas Gerais. Trata-se de um estudo descritivo, qualitativo realizado com 13 mulheres. Os dados foram coletados entre agosto e setembro de 2022 por meio de uma entrevista analisada mediante Análise Temática. Observou-se um déficit de orientações sobre as vias de parto no pré-natal, que se manifesta em forma de despreparo da gestante para lidar com o parto. As mulheres que realizaram o parto cesáreo foram motivadas pela possibilidade de planejamento antecipado, medo de realizar o parto normal e ser uma oportunidade para conciliar o parto com a laqueadura. A motivação pelo parto normal foi o medo da cesariana e um tempo de recuperação mais breve nesse tipo de parto. Conclui-se que as orientações sobre as vias de parto devem ser praticadas desde o início do pré-natal e ter a participação de toda a equipe para orientar sobre os riscos e benefícios para aumentar a autonomia e conhecimento da gestante sobre as vias de parto.
MANIFESTAÇÕES NEURO-OFTÁLMICAS DO SARS-COV-2 E POSSÍVEIS MECANISMOS CAUSADORES: UMA REVISÃO DE LITERATURA NARRATIVA
Authors: Palitot Galdino Villany Maria , Palitot Galdino Elizabeth Maria , Palitot Galdino Maria Clara , Pereira Dias Chaves Mário Augusto
Published: September 2023

O coronavírus da síndrome respiratória aguda grave 2 (SARS-CoV-2) é o causador da doença denominada COVID-19, que teve o seu primeiro caso na cidade de Wuhan, província de Hubei, China, em dezembro de 2019 e foi declarada uma pandemia em março de 2020 pela Organização Mundial de Saúde (OMS). Apesar das manifestações oftálmicas da COVID-19 terem um amplo espectro, já foi sugerida uma correlação entre a sua maior incidência e pacientes com a doença sistêmica mais grave. Hoje, relatos de casos e revisões de literatura representam a principal fonte de informação para construir um conhecimento comum acerca das manifestações neuro-oftálmicas da COVID-19. Com o intuito de contribuir para esse objetivo, foi feita esta revisão de literatura narrativa com artigos científicos publicados nas bases de dados: SCIELO, LILACS, MEDLINE e PUBMED, disponíveis entre 1 e 30 de janeiro de 2023, considerando a sua relevância dentro do tema abordado. Foi feita uma análise focando nas manifestações neuro-oftálmicas em pacientes que foram infectados pelo SARS-CoV-2, discutindo o conhecimento atual sobre o assunto e dando ênfase aos três mecanismos mais apontados como possíveis causadores dessas manifestações: o dano tecidual por fatores autoimunes mediados, o efeito direto do próprio vírus e o estado pró-coagulante da infecção por COVID-19. Algumas das manifestações neuro-oftálmicas consideradas as mais descritas na literatura foram: ptose, diplopia, nistagmo, paralisia do terceiro e sexto nervo craniano, síndrome de Miller-Fisher associada, neurite óptica, oftalmoplegia externa e alteração pupilar. Como o número de casos relatados continua crescendo, uma maior e melhor percepção do assunto e dos mecanismos envolvidos será, com o tempo e através de novos estudos, elaborada.
Understanding the Impact of Enterprise Architecture Driven Dynamic Capabilities on Agility: A Variance and fsQCA Study
Authors:   Open University, the Netherlands, Wetering Rogier van de
Published: September 2023

Abstract Background: As the modern business environment is highly volatile and demanding, orchestrating all business and IT components and capabilities is crucial. Firms use enterprise architecture (EA) for this purpose. However, it is currently by no means clear how EA-driven firm capabilities facilitate becoming agile. When firms are agile, they can recombine digital resources to change the business practice while coping with uncertainty and recovering rapidly from disruption through innovative digital technologies. Method: This study embraces the dynamic capability view, develops a model, and validates the associated hypotheses using cross-sectional data from 176 firms using a Partial least squares structural equation modeling (PLS-SEM) and a Fuzzy-set qualitative comparative analysis (fsQCA) approach. Results: The outcomes show that EA-driven dynamic capabilities are a crucial antecedent of digital project benefits. In turn, these benefits positively enhance agility. The study also embraces a complementary configuration perspective in unfolding various capability configurations that explain high levels of distinct digital project benefits. Conclusion: Hence, this study’s outcomes support the theorized model, and both the PLS and configurational outcomes shed light on how to become digitally agile in practice.
New-onset atrial fibrillation in patients with SARS-CoV-2 pneumonia as a manifestation of acute myocardial injury
Authors: Makeeva Tatyana I. , Zbyshevskaya Elizaveta V. , Mayer Mark V. , Talibov Faiz A. , Saiganov Sergey A.
Published: September 2023

BACKGROUND: Over the past 3 years, the prevalence of atrial fibrillation (AF) has increased significantly worldwide, which was associated with the pandemic caused by SARS-CoV-2. It is accompanied by an increase in the cases of ischemic stroke, myocardial infarction, and development of heart failure due to acute myocardial injury. Given the high lethality of SARS-CoV-2 infection (COVID-19), studying the characteristics of new-onset AF is essential.
AIM: The study aims at determining the predictors of new-onset AF in patients with COVID-19 pneumonia and at analyzing the clinical and pathophysiological characteristics of acute myocardial injury.
MATERIALS AND METHODS: In 36 patients aged 4482 years (average 68.0) with COVID-19 pneumonia, AF paroxysms were recorded for the first time. All of them underwent computed tomography of the chest, electrocardiography, and echocardiography. The left ventricular ejection fraction was calculated using the Simpson method. Oxygen saturation was determined as blood oxygen saturation. Clinical blood tests were performed, C-reactive protein (CRP), ferritin, D-dimer, fibrinogen, and troponin I levels were measured.
RESULTS: Along with the well-known predictors of AF development (arterial hypertension, coronary heart disease, left ventricular myocardial hypertrophy, and left atrial dilatation), with COVID-19 pneumonia, new-onset AF paroxysms were recorded in patients of the middle, elderly, and late-life age. In 44.4% of patients with AF, cardiomegaly occurred with dilatation of both atria and ventricles. With decreased left ventricular ejection fraction, the incidence of AF paroxysms reached 61.5%. With preserved ejection fraction, AF paroxysms occurred much less frequently (27%). In patients with AF, the extent of lung damage is on average 62.5% (2080%) with oxygen support saturation of 93% (7697%). Serum troponin I levels of 2000 ng/L indicated acute myocardial injury. CRP and blood ferritin values confirmed the presence of a pronounced inflammatory component in myocardial injury. High concentrations of blood fibrinogen and D-dimer, reaching 16,301 ng/mL, were associated with a tendency to hypercoagulation in patients with AF and COVID-19 pneumonia.
CONCLUSIONS: COVID-19 has a direct damaging effect on the myocardium and probably persists for a long time, which may induce AF in patients with acute pneumonia.
Recurrence of Arrhythmias after Thoracoscopic MAZE procedure
Authors: Lyashenko Vitaly V. , Ivanchenko Andrey V. , Postol Angelika S. , Azizov Sardor N. , Vygovsky Alexander B. , Schneider Yuri  A.
Published: September 2023

BACKGROUND: Thoracoscopic version of the MAZE operation alone or in combination with catheter ablation (hybrid approach) has become widespread in the treatment of atrial fibrillation (AFib). However, recurrences of arrhythmias after such operations, in particular recurrence of AFib, remain unresolved problem.
AIM: The aim of this study was to establish the structure of arrhythmia recurrence in patients with long-standing persistent AFib after primary epicardial ablation using the Dallas lesion set technique, as well as determining the optimal RFA strategy for recurrence.
METHODS: 138 catheter ablation procedures for 100 patients, who applied with recurrence of various atrial arrhythmias after thoracoscopic MAZE. 34 patients had 2 or more RFA (31 pts 2, 2 pts 3, 1 pts 4).
RESULTS: After Dallas lesion set thoracoscopic ablation in the structure of recurrences dominated: 1 AFib recurence; 2 incisional left atrial flutter. After the operation, a potential arrhythmogenic substrate remains, which must be fully eliminated by RFA (in addition to ablation the main cause of recurrence). This minimally necessary intervention implies: control and reisolation of the pulmonary veins; control and reisolation of the posterior wall; septal line from the mitral valve to the right superior pulmonary vein with Y-shaped branch to the left superior pulmonary vein; cava-tricuspid isthmus-blockade. This will eliminate and prevent in the future potentially possible incisional arrhythmias in fragmentary scars after thoracoscopic MAZE procedure. The return of AFib represents the most difficult group of patients. Restoration of sinus rhythm in recurrent AFib after epicardial ablation is possible, but may require extensive ablations in both atriums, as a result of repeated procedures, until all potential arrhythmia mechanisms, present in a particular patient, are eliminated.
CONCLUSIONS: Catheter ablation remains the only method of effective treatment of recurrences after thoracoscopic MAZE procedure. The complexity and multicomponent nature of long-standing AFib causes the frequent need for repeated procedures, especially in cases of recurrence of atrial fibrillation.
Penggunaan gelatin kulit ikan cobia (Rachycentron canadum) untuk perbaikan karakteristik fruit leather buah naga merah
Authors: Febrianti Annisa Amalia , Susanto Eko , Purnamayati Lukita , Sumardianto Sumardianto , Suharto Slamet
Published: September 2023

Gelatin ikan merupakan biopolimer yang diperoleh dari hidrolisis kolagen ikan. Kolagen dapat dibuat dari limbah hasil pengolahan produk di antaranya adalah kulit ikan cobia. Fruit leather merupakan dendeng buah berbentuk lembaran-lembaran kompak, elastis, dan kenyal. Tujuan dari penelitian ini untuk menentukan konsentrasi penambahan gelatin yang terbaik dalam menghasilkan fruit leather. Fruit leather dibuat dari buah naga merah. Metode penelitian menggunakan rancangan acak lengkap dengan perlakuan perbedaan konsentrasi gelatin kulit ikan cobia (0; 0,5; 1; 1,5 dan 2%). Parameter yang dianalisis meliputi kuat tarik, ketebalan, warna, kadar air, kadar protein, aktivitas antioksidan, dan kadar antosianin. Hasil analisis data menunjukkan bahwa seluruh perlakuan penambahan gelatin kulit ikan cobia mempunyai pengaruh yang berbeda nyata (p<5%) terhadap semua parameter uji. Nilai tertinggi diperoleh dari perlakuan konsentrasi gelatin kulit ikan cobia 2% dengan karakteristik: kuat tarik 1,56 Mpa, ketebalan 2,23 mm, warna L* 28,35; a* 7,70; b* 8,64, kadar air 16,66%, kadar protein 14,96%, antioksidan 41,21%, dan antosianin 5,43 mg/100 g. Gelatin kulit ikan cobia dapat memperbaiki karakteristik fruit leather buah naga merah.
Pengembangan produk sambal roa inovatif melalui formulasi undur-undur laut
Authors: Riyanto Bambang , Syafitri Utami Dyah , Trilaksani Wini , Ulya Immatul
Published: September 2023

Sambal roa merupakan salah satu sambal khas nusantara dengan rasa dan aroma ikan roa asap yang khas. Produksi ikan roa yang terus menurun menuntut adanya inovasi pengembangan produk. Undur-undur laut merupakan bahan pengganti yang potensial, karena memiliki cita rasa krustasea/rebon yang mirip dengan terasi serta kandungan karotenoid yang dapat berperan sebagai pewarna alami.  Penelitian ini bertujuan untuk menentukan formula sambal roa inovatif melalui formulasi cabai, ikan roa asap, dan undur-undur laut  menggunakan I-optimal mixture amount design. Penelitian meliputi modifikasi, pembuatan, dan uji sensori deskriptif sambal roa, optimasi formulasi sambal roa dengan undur-undur laut, serta perbandingan antara sambal roa dengan undur-undur laut dan sambal roa komersial. Formula sambal roa didasarkan pada jumlah total campuran sebesar 150 g dengan proporsi cabai 40%-70%, ikan roa asap 20%-30%, dan undur-undur laut 35%-50%. Hasil formulasi tersebut, diperoleh keberterimaan optimal dengan proporsi cabai 40%, ikan roa asap 21,68%, dan undur-undur laut 38,32%. Karakteristik sambal roa inovatif dengan formulasi cabai, ikan roa asap, dan undur-undur laut adalah berbentuk pasta, memiliki viskositas 9.547±948,54 cP, warna oranye kemerahan L*: 19,64±0,76, a*: 17,58±0,80, dan b*: 22,75±0,68. Sensori aroma khas krustasea (undur-undur laut) dapat dirasakan, serta memiliki sensasi pedas dengan kadar kapsaisin 701,78±0,028 ppm, kadar protein 11,32±0,007%, kadar lemak 15,28±0,049%, aktivitas air (Aw) 0,84±0,0001, dan total mikrobiologi 6,3×10²±1,90 koloni/g.
Analisis kandungan proksimat Octopus cyanea dari perairan Nusa Tenggara Timur
Authors: Soewarlan Cindy , Toruan Lumban Nauli Lumban , Saraswati Suprabadevi Ayumasari
Published: September 2023

Octopus cyanea tersebar luas di perairan Nusa Tenggara Timur, dijual pada pasar-pasar tradisional dan diekspor ke Eropa. O. cyanea diperdagangkan untuk konsumsi, namun demikian belum terdapat informasi nutrisi yang memadai terkait organisme ini di Nusa Tenggara Timur. Penelitian ini bertujuan untuk menentukan kandungan nutrisi utama dari O. cyanea berupa kadar air, karbohidrat, lemak, protein, abu, dan serat kasar. Sampel gurita diperoleh dari tangkapan nelayan di Teluk Kupang yang berlabuh di Pasir Panjang Kota Kupang dan dari perairan Perumaan-Nangahale Kabupaten Sikka. Preparasi sampel: masing-masing lokasi diambil tiga sampel dari trip penangkapan yang berbeda. Delapan tentakel dari setiap sampel dipotong, dicampur, dan dihaluskan untuk analisis analisis proksimat meliputi: kadar lemak dengan metode Soxhlet, kadar protein menggunakan metode Kjedahl, penentuan kadar air, kadar abu, dan serat kasar mengacu kepada AOAC. Perhitungan terhadap hasil dianalisis menggunakan rata-rata untuk setiap lokasi pengambilan sampel. Hasil penelitian menemukan komponen terbesar O. cyanea adalah air 70,79-74,36%, protein 13,55-18,41%, karbohidrat 5,44-6,37%, abu 2,23-3,43%, lemak 2,20-2,22% dan serat kasar 1,51-2,54%. Informasi ini dapat digunakan konsumen untuk memperkirakan bahaya yang mungkin berisiko pada kondisi kesehatan tertentu. Selain itu untuk kepentingan pembinaan tindakan pencegahan terhadap penurunan kualitas.
Methods for Evaluating Database Coverage
Authors: Brody Stacy , Brill Rachel , Butcher Robyn
Published: September 2023

Purposes: In this article, we describe two methods to evaluate database content coverage, illustrating their use with the example of evaluating databases for coverage of medical education literature.
Method names: Though several methods for evaluating database content coverage have been described, the two used herein, referred to as the reference list search method and the journal method, use traditional librarian skills and tools and can be used across a variety of topic areas.
Description: In this paper, we describe two approaches to evaluating database coverage. For each method, we use the example of evaluating databases for their coverage of medical education literature. In the reference list search method, we search for references from comprehensive reviews or bibliographies to determine their presence in databases. In the journal method, we describe the indexing status and coverage of key publications in databases.
Strengths: These methods use established librarian skills and tools and can be applied to a wide variety of topics.
Limitations: The results of each method depend on the quality and comprehensiveness of the original source material: comprehensive reviews and bibliographies for the reference list search method and publication lists for the journal method.
Building Trust in State Actors: A Multi-Site Experiment with the Colombian National Police
Authors: Abril Verónica , Norza Ervyn , Perez-Vincent Santiago M. , Tobón Santiago , Weintraub Michael
Published: September 2023

Low trust in state actors constrains state capacity, hindering growth and development. This paper studies how state actors can build public trust by improving the quality of their interactions with citizens. We first propose a mechanism linking improved interactions to public trust, defined as the belief that the state actor implements welfare-enhancing policies. Improved interactions lower the expected burden of engaging with the state actor, promoting compliance. This motivates citizens to believe compliance is worthwhile, increasing trust in the state actor. We then empirically assess the relationship between the quality of interactions and public trust in the Colombian National Police. We experimentally evaluate an intervention that retrains officers across five major cities in procedural justice principles such as fairness and respect while intensifying police-citizen interactions. The intervention was purposefully designed to be low-cost in terms of financial and human resources. We find that the intervention improved public trust, willingness-to-pay for police services, and citizens perceptions of fair treatment, suggesting low-cost interventions can help build trust between police and communities. We also find a limited impact on officers trust in citizens and their beliefs about citizens public trust, implying that institutional culture change may require more profound efforts.
Цифровизация образования: актуальность и необходимость
Authors: Абрамова Н.И , Васильева Т.Г , Виткевич Н.Л.
Published: September 2023

В статье рассматривается понятие цифровизации, проведен анализ влияния цифровизации на систему образования. Показано как развитие образования неотъемлемо связано с внедрением в учебный процесс компьютерных технологий. Выявлены плюсы и минусы влияния цифровизации на образование. Описаны перспективы развития цифровой образовательной среды в России
Волонтерская деятельность студентов как фактор социализации
Authors: Дорофеев А.А. , Дорофеева Е.Н., , Скрыпников И.В
Published: September 2023

Волонтерство является важным аспектом студенческой жизни, оказывая положительное влияние на социальную адаптацию, развитие социальных навыков и формирование ценностей у студентов. Статья основывается на исследованиях, которые подтверждают, что участие в волонтерской деятельности способствует развитию коммуникационных навыков, лидерства, эмпатии и социальной ответственности у студентов. Также рассматривается влияние волонтерства на успешную адаптацию студентов именно к университетской жизни и формирование их ценностей. Исследования также подчеркивают, что активное волонтерство стимулирует студентов к проактивному подходу к решению социальных проблем и развитию критического мышления. В заключении подчеркивается, что волонтерская деятельность студентов имеет важное значение для их развития, способствуя их личностному и профессиональному росту
Применение информационно-коммуникативных технологий в иноязычном обучении
Authors: Казакова Т.А.
Published: September 2023

Статья посвящена вопросам применения информационно-коммуникативных технологий в процессе обучения иностранному языку студентов высшей школы. Ино-язычное обучение с использованием информационных технологий имеет ряд пре-имуществ, что позволяет повысить эффективность организации образовательного процесса в вузе.
Воспитание в условиях цифровизации образования в педагогическом вузе
Authors: Калугина Е.В. , Замышляева А.С.
Published: September 2023

В современных условиях образования наблюдается интенсивная цифровизация воспитательного процесса, нацеленная на модификацию всего учебного процесса, путем внедрения новых педагогических, информационно-коммуникативных технологий. В статье приводятся характерные черты цифрового поколения студентов, показана специфика воспитательной работы в условиях цифровизации образования в педагогическом вузе, предложены методы, приемы и инструментарий, применяемый преподавателями при организации воспитательно-образовательной деятельности.