bluuebunny/crossref_metadata_2025 huggingface dataset:
The effectiveness of dexmedetomidine in patients with severe COVID-19
Authors: Andreychenko Sergey A. , Bychinin Mikhail V. , Mandel Irina A. , Klypa Tatiana V.
Published: December 2021

Background: Mortality in patients with severe COVID-19 remains high. Finding therapies that can improve the outcome in these patients is an urgent task.
Aims: To evaluate the clinical efficacy of dexmedetomidine in the complex treatment of patients with a severe course of COVID-19.
Methods: The retrospective study included 50 adult patients with severe COVID-19 admitted to the intensive care unit (ICU). The primary outcome of the study was the incidence of delirium. The secondary results of the study were the dynamics of gas exchange indicators (PaO2 and PaCO2) and inflammatory markers (C-reactive protein, CRP; procalcitonin, lymphocyte count, and neutrophil-lymphocyte ratio, NLR) on day 3 and day 5 of the treatment, as well as the duration of mechanical ventilation (MV), length of stay (LOS) in the ICU and in the hospital and mortality.
Results: The incidence of delirium did not differ between the dexmedetomidine group and the control group (41 and 48%, respectively; p=0.661). The LOS in the ICU and in the hospital, as well as the MV duration, was comparable between the groups. However, the hospital mortality in the dexmedetomidine treatment group was lower than that in the control group (10.3% and 42.9%, respectively; p=0.008). The addition of dexmedetomidine to the therapy complex did not affect the blood gas composition but contributed to the increase in the number of lymphocytes (p=0.006) and to the NLS decrease (p=0.002) by the fifth day of treatment. At the same time, no significant changes in the CRP and procalcitonin levels were observed.
Conclusion: In the treatment group, the mortality was statistically significantly lower than it was in the control group. At the same time, the use of dexmedetomidine did not reduce the incidence of delirium, the length of stay in the ICU and in the hospital, and the duration of mechanical ventilation in patients with severe COVID-19. The revealed relationship between the use of dexmedetomidine and NLR and the number of lymphocytes suggests an immune-mediated effect on the outcome in this category of patients. Prospective randomized trials are needed to confirm the beneficial effects of dexmedetomidine on the immune system and mortality.
Neurological aspects of COVID-19
Authors: Aliyeva M B , Saparbayev S S , Ayaganov D N , Kurmangazin M S , Tuychibaeva N M
Published: December 2021

The coronavirus disease COVID-19 began to spread worldwide in December 2019 from the city of Wuhan (China). COVID-19 is often accompanied by fever, hypoxemic respiratory failure and systemic complications (for example, gastrointestinal, renal, cardiac, neurological, and hepatic lesions), thrombotic phenomena. Central nervous system damage is caused by the primary effect on it, direct neuroinvasion of the virus, and more often by secondary effect due to systemic hyperinflammation. Neurological manifestations include fatigue, headache, insomnia, and olfactory/taste disorders. Neurological manifestations and complications of COVID-19 are diverse: (1) cerebral circulatory disorders, including ischemic stroke and macro/microhemorrhages; (2) encephalopathy; (3) para/postinfectious autoimmune complications, such as GuillainBarre syndrome; (4) meningoencephalitis; (5) neuropsychiatric complications (psychosis and mood disorders). In terms of pathogenesis, neurological disorders in COVID-19 can be caused by neurotropicity and neurovirulence of SARS-CoV-2, cytokine storm, hypoxemia, homeostasis disorders, as well as their combined effects. COVID-19 adversely affects the course and prognosis of chronic neurological disorders in comorbid patients. The review highlights the need for vigilance to early neurological complications in patients infected with SARS-CoV-2 and other coronaviruses, especially since some neurological complications may precede respiratory manifestations.
Preventive esophagomyobronchoplasty as a method to prevent the failure of the bronchial stump in pneumonectomy for lung cancer
Authors: Sulimanov R A , Sulimanov R R , Spassky E S , Fedorova T V , Kholodova M A
Published: December 2021

Aim. Comparative analysis of insufficiency rate of bronchial stump sutures in pneumonectomy for lung cancer, depending on suturing techniques.

Methods. A patented technique for bronchial stump suturing has been introduced into the practice of the GOBUZ clinic Novgorod Regional Clinical Hospital based on the Department of thoracic surgery since 2015 for pneumonectomy for lung cancer. Before the introduction of the developed technique, various generally accepted methods of bronchial stump forming were used (mechanical suture, manual suture, their combination, bronchial stump coverage with mediastinal pleura, pericardial flap). A retrospective analysis of 173 case histories and operational protocols of patients with lung cancer who underwent pneumonectomy was carried out for the failure of bronchial stump sutures when using conventional suturing techniques between 2010 and 2014 (the first group of patients). We also performed a retrospective and prospective analysis of 204 case histories and operational protocols of patients in a similar clinical group when using a patented suturing technique between 2015 and 2020 (the second group of patients). Statistical analysis was carried out by using Statistica 10.0 software (StatSoft, Inc. 2011). The qualitative and quantitative indicators were analyzed by using the Pearsons 2-test with Yatess correction.

Results. A retrospective analysis shows that the failure rate in the use of generally accepted bronchial stump suturing techniques for 20102014 was 10.4%. After the implementation of the method of preventive esophagobronchomyoplasty, complications as bronchial stump suture failure were not detected in any case between 2015 and 2020.

Conclusion. The study shows high efficiency, a decrease in the incidence of complications as the failure of bronchial stump sutures in the use of the developed method of preventive esophagomyobronchoplasty in pneumonectomy for lung cancer.
Viktor Vasilievich Trusov — organizer of endocrinology service of Izhevsk
Authors: Khalimov E V , Mikhailov A Yu , Styazhkina S N , Zavalina M A , Likhovskikh S I
Published: December 2021

The article is devoted to the 85th anniversary of Professor Viktor Vasilyevich Trusov (19362012), one of the prominent representatives of the therapeutic, scientific school of the Izhevsk State Medical Academy. In the range of diverse scientific interests and developments of Viktor Vasilyevich, a significant part was the issues of practical support to patients with endocrinological pathology, including patients with diabetes mellitus. Professor V.V. Trusov was a member of the Board of Russian Association of Endocrinologists, a member of the European Association for the Study of Diabetes, a member of the American Diabetes Association, worked on the problems of optimizing care for patients with diabetes. The article highlights the diabetology segment of the endocrinology service in Izhevsk on the materials of the endocrinological department of the State Clinical Hospital No. 6. The role of Professor Viktor Vasilyevich Trusov in the organization of the endocrinological center of Izhevsk, the viability of the methodological guidelines and recommendations laid down by him in the organization of care for patients with diabetes mellitus was noted. The organization of the work of the endocrinology center are considered. The analysis of the main indicators of the prevalence of diabetes mellitus was carried out according to the data of the endocrinology department (20172020). The special place of the diabetic foot clinic in the work of the center is highlighted. Modern and original methods of management of such complications of diabetes mellitus as diabetic foot syndrome are presented.
Estimation of the proportionality of the physical development of children of the Khanty-Mansiysk autonomous district – Yugra with non-differentiated connective tissue displasion
Authors: Shevnin I. A. , Ilyushchenko N. A. , Ragozin O. N. , Ragozin O. V. , Ermakova N. V.
Published: December 2021

Background. Assessment of the physical development of children in individual regions of the Russian Federation does not lose its relevance and requires constant updating, in this regard, it is important to study it in children adapting to the climatic and geographical conditions of the North, as well as the effect of undifferentiated connective tissue dysplasia on it.

Aim. Aim of the study is to study the gender and age characteristics of the proportionality of physical development in children with undifferentiated connective tissue dysplasia living in the Khanty-Mansiysk Autonomous Okrug Yugra.

Materials and methods. The analysis of physical development of 528 children of the second childhood and adolescence, living in the Khanty-Mansi Autonomous Okrug Yugra, was carried out. The study group consisted of 342 children (248 boys and 94 girls) with a diagnostically significant number of undifferentiated connective tissue dysplasia symptoms (from 6 to 18 stigmas). The comparison group included 186 children (111 boys and 75 girls) who did not score a significant threshold of phene signs (from 0 to 5 stigmas). Physical development was assessed according to the Quetelet II weight-height index, chest-weight indices: Pignet, Vervek, and Brugsch, as well as proportionality indices: sternum, shoulder width, pelvic width, torso shape, arm and leg length indices, cranial and facial indices, interorbital-circular index.

Results. Children without undifferentiated connective tissue dysplasia during the second childhood have a tendency to malnutrition, and are characterized by a weak physique with a tendency to narrow chest. In adolescence, the tendency towards weakness of the physique persists, while height-weight ratios deviate towards normotrophy. Children with undifferentiated connective tissue dysplasia during the second childhood and adolescence have a rectangular or trapezoidal body with an average length, as well as long upper and lower limbs relative to the length of the body.

Conclusion. The impact of the socio-ecological factors of the North neutralizes the differences in the rates of physical development in healthy children and persons with disorders caused by congenital disorders of organogenesis of the undifferentiated connective tissue dysplasia type.
Transpiloric feeding in gastroesophageal reflux in neonatology
Authors: Smirnov O. G. , Gorbachev V. I. , Aleinikova N. G.
Published: December 2021

Optimizing nutritional support is essential for critically ill children, and premature infants are particularly vulnerable to the effects of prolonged fasting. There is a lot of evidence in the scientific literature for the benefits of enteral nutrition. It is known that premature babies need an individual approach to nutrition due to the prevalence of catabolic processes, while treatment in the intensive care unit requires a surplus of calories. Timely introduction of enteral nutrition helps to reduce morbidity and mortality in this population. Gastroesophageal reflux is common in preterm infants. When there is a decrease in tolerance to enteral feeding, doctors usually prefer parenteral nutrition. However, its use can be associated with metabolic, infectious and iatrogenic complications. A step-by-step therapeutic approach is recommended in the treatment of GER in preterm infants. Conservative treatment should be considered as first-line therapy in children without clinical complications. Feeding through a gastric tube is not always well tolerated by seriously ill people patients. As for the treatment of complicated GER, extensive studies show that the use of transpiloric feeding is comparable in effectiveness to fundoplication. Transpiloric feeding tube can be justified as a strategy for treating GER that is refractory to conservative therapy.
Lysosomal storage diseases. Mucopolysaccharidosis type III, sanfilippo syndrome
Authors: Gorbunova V. N. , Buchinskaya N. V.
Published: December 2021

The review describes the clinical, biochemical and molecular genetic characteristics of autosomal recessive mucopolysaccharidosis type III, or Sanfilippo syndrome. This is a genetically heterogeneous group of rare, but similar in nature, diseases caused by a deficiency of one of the four lysosomal enzymes involved in the degradation of heparan sulfate. All types of mucopolysaccharidosis III are characterized by severe degeneration of the central nervous system in combination with mild somatic manifestations, which is explained by the accumulation of high concentrations of heparan sulfate in the lysosomes of various cells, including the central nervous system. The primary biochemical defect in the most common type of mucopolysaccharidosis IIIA, occurring with a frequency of 1 : 105 and presented in 60% of all cases of the disease, is heparan-N-sulfatase, or sulfamidase deficiency. Mucopolysaccharidosis IIIB type occurs twice less often and accounts for about 30% of all cases of Sanfilippo syndrome. It is caused by the presence of inactivating mutations in the lysosomal -N-acetylglucosaminidase gene. Mucopolysaccharidosis IIIC and IIID are 4% and 6%, and occur at frequencies of 0.7 and 1.0 : 106. Mucopolysaccharidosis IIIC is caused by inactivating mutations in the gene of membrane-bound lysosomal acetyl-CoA:-glucosaminid-N-acetyltransferase, or N-acetyltransferase. Mucopolysaccharidosis IIID is based on the deficiency of lysosomal N-acetylglucosamine-6-sulfatase. The role of experimental models in the study of the biochemical basis of the pathogenesis of Sanfilippo syndrome and the development of various therapeutic approaches are discussed. The possibility of neonatal screening, early diagnosis, prevention and pathogenetic therapy of these severe lysosomal diseases are considered. As an example, a clinical case of diagnosis and treatment of a child with type IIIB mucopolysaccharidosis is presented.
Livre Blanc : Sécurité et sûreté dans le secteur du tourisme Volume 3 : Études de cas et témoignages
Authors:   World Tourism Organization (UNWTO)
Published: December 2021

Ce Livre blanc sur la sécurité et la sûreté dans le tourisme, présenté en 3 volumes, est le fruit du partenariat clé entre l’Organisation mondiale du tourisme, l’Agence de développement de l’Union africaine et l’Union économique et monétaire ouest-africaine. Il a pour ambition de donner aux acteurs du secteur du tourisme tous les outils nécessaires pour concevoir et mener à bien leurs propres politiques de sécurisation, en fonction de leurs objectifs, moyens et contraintes propres. Cette publication vise à jouer un rôle majeur dans le renforcement de la résilience du secteur du tourisme, en Afrique et dans le reste du monde, et contribuer ainsi à une croissance inclusive et un développement durable des économies locales. Ce volume 3 est le dernier du Livre blanc sur la sûreté et la sécurité comme éléments clés dans le développement du secteur du tourisme. Il couvre des exemples d’initiatives et de réussites tirées des expériences de nombreux professionnels qui ont souhaité contribuer à partager leurs bonnes pratiques, leurs idées et leur savoir-faire. Sa première partie se base sur des entretiens menés avec des pays de tous les continents et chacun d’eux développe une ou deux initiatives menées par un de ces pays. Ces exemples peuvent aider les lecteurs à se familiariser avec certaines initiatives, voire les inspirer et leur donner envie de reproduire tout ou partie de ces programmes. Sa deuxième partie se compose de témoignages d’experts en gestion de crise qui ont bien voulu partager avec nous leur savoir-faire et leur expérience. Ces témoignages précieux permettront au lecteur de se faire une meilleure idée de la difficulté à gérer une crise quand on y est peu préparer et ainsi renforcer l’argument principal de ce Livre blanc, qui est que l’investissement dans la sûreté et la sécurité et la préparation à la crise sont des éléments fondamentaux de la création d’un secteur touristique national attractif, résilient et durable.
Asthma Mortality in Spain From 1980 to 2019: Trends and Perspectives in the New Treatment Era
Authors: Delgado-Romero J , Pereyra-Rodriguez JJ
Published: December 2021

Background: Previous studies suggest that asthma mortality rates in Spain have been decreasing in recent years. However, this trend is not homogeneous across age groups. Objective: To analyze asthma mortality rates over a 40-year period, focusing on changes associated with the development of new therapeutic approaches. Methods: Death records and mid-year population data were collected from the National Statistics Institute. Using the direct method, agestandardized mortality rates were calculated for the overall population and for each sex and age group. Significant changes in mortality trends were identified using joinpoint regression analysis. The independent effects of age, period, and cohort and potential years of life lost due to asthma were also analyzed. Results: Age-standardized asthma mortality rates decreased in Spain from 7.38 to 2.03 deaths per 100 000 from the first to the last quinquennium of the study (1980-1984 to 2015-2019) for the whole population. This decrease was more intense among men, where a decrease from 10.37/100 000 to 0.91/100 000 was observed compared with 5.53 to 2.77/100 000 in women. Mortality decreased in all age groups. During the last 3 years, the decrease stabilized in patients aged >64 years but increased in those aged 35-64. Mortality has been decreasing rapidly since the 1990s in patients aged <35 years. Conclusion: Asthma mortality rates began to decline in 1980. The decrease was observed among younger cohorts starting in the 1990s, thus confirming earlier trends. Improved diagnosis and development of new therapies for asthma may have played a role in the changes observed. Close monitoring of asthma mortality rates is necessary to confirm these trends.
Behcet’s disease: a review
Authors: Reyes-Weaver Daniela Ann , Plata-Jimenez Kevin Luis , Melo-Acevedo Raul
Published: December 2021

Behcet's disease (BD) is a complex systemic vasculitis with an etiopathogenesis that remains unclear. It has a strong geographic association as well as a genetic propensity linked to the HLA-B51 factor and interactions between genetic and environmental factors. The typical age of onset is 25 to 40 years old and it is more common in men, who also have a more severe condition. Occlusive vasculitis is the hallmark of this condition, which can affect vessels of all diameters. Oral ulcers, genital ulcers, skin lesions, pathergy reaction as well as involvement of other systems and organs such as ophthalmic, neurological and vascular lesions, among others, are used to make the diagnosis. Uncontrolled neutrophil activation, activation of the humoral and cell immune systems, toxic proteins and infectious agents such as herpes simplex and streptococci are all involved in their pathophysiology. Due to the heterogeneity and several systems affected, the treatment is individualized and focused on treating each clinical manifestation.
Comparative assessment of efficacy of artery ligation versus rubber band ligation for management of haemorrhoids in Southern Rajasthan
Authors: Agrawal Mathura Prasad , Pateriya Anurag , Samar Surendra Kumar
Published: December 2021

Background: One of the commonest complaints presenting in the surgical out patient department (OPD) is haemorrhoids. Commonest types of haemorrhoids are grade II and III. There is a wide number of modalities that can be adopted for their management. It depends on the skill of the surgeon and preferences of the patient. The present study was designed to ascertain if two modalities of artery ligation and band ligation are comparatively equal or not in managing symptomatic grade II and III haemorrhoids in Rajasthan.Methods: The study comprised of 100 subjects who were randomly divided in two groups based on the procedure to be followed. The subjects were told about the study and its objective.Results: The observations reported that among the selected study population there were more relapses in band ligation as compared to artery ligation.Conclusions: This led to the conclusion that despite its painful and traumatic methodology, haemorrhoid artery ligation still provides a better outcome.
A prospective analytical study on the effect of posterior femoral condylar offset on range of knee flexion in patients undergoing cruciate retaining total knee arthroplasty
Authors: G. Ranjit Kumar , Babu Murukan , Jose Tom
Published: December 2021

Background: Osteoarthritis (OA) of knee joint is a common problem in our society causing pain, deformity, oedema, malalignment and limitation of activity. Total knee arthroplasty (TKA) is the surgery done for treatment of this problem. The range of movement obtained after TKA is an important factor influencing success of surgery. Posterior femoral condylar offset (PCO) is one of the parameters influencing range of movement after surgery. The dearth of studies in Indian population and contradicting results in already conducted studies has been observed in assessing the effect of PCO on range of knee flexion in patients undergoing TKA. Hence this study is done to explore this correlation.

Methods: A prospective analytical study on 36 patients (50 knees) who underwent cruciate retaining TKA at Department of Orthopaedics, Rajagiri Hospital, Aluva. PCO and posterior femoral condylar offset ratio (PCOR) were calculated radiologically before and after TKA. Range of flexion (ROF) and knee society scores (for functional outcome assessment) were recorded preoperatively and postoperatively (at 6 weeks and 3 months).

Results: The study found a strong positive correlation between PCO difference and ROF difference (r=0.735). Strong positive correlation was also found between PCOR difference and ROF difference (r=0.777). Both these correlations were statistically significant (p<0.05).

Conclusions: The study enlightened us about the point that PCO is an important factor in attaining a good ROF after cruciate retaining TKA.
Reuse of wastewater from fish farm for irrigation in aerobic rice (Oryza sativa L.) cultivation
Authors: Ibadzade Marks , Székely Árpád , Szalóki Tímea , Penksza Károly , Jancsó Mihály
Published: December 2021

The utilization of wastewater in irrigated agriculture is becoming vital in those regions where access to freshwater is low. Wastewater in rice cultivation as an alternative water source can also play significant role in the future. This experiment was conducted in Szarvas, Hungary to evaluate the performance of a Hungarian rice variety (‘Janka’) irrigated with a saline effluent water from an intensive fish farm. Irrigation was carried out both in the form of direct use (I1) of the wastewater and with two additional treatments: I2 - gypsum supplementation, I3 - wastewater dilution with oxbow lake water and gypsum supplementation. Water from the local oxbow lake was set as irrigation control. During the experiment, the quality parameters, grain size and mineral composition (Na, K, Mg, Ca, and P) of rice seeds were measured. The study showed that the application of wastewater and treated wastewater decreased many of these parameters. I1 significantly reduced the thousand grain weight of paddy and cargo seeds. Meanwhile, I2 and I3 had a significant negative effect on the head rice percentage. Grain length, width and ratio were also decreased significantly compared to the control irrigation. Only the mineral content of the grains remained statistically unchanged. The current study showed that the selected rice variety generally reacted negatively to the wastewater and also to the treated wastewater.
Control of plant pathogen Fusarium spp. with compost, compost tea application : A review
Authors: Orosz Viktrória , Tomócsik Attila , Demeter Ibolya , Aranyos Tibor József , Makádi Marianna
Published: December 2021

Compost has been used in agriculture for a long time for nutrient supply. However, in recent decades the disease suppressive effects of the compost and its aqueous extracts are in the focus of the research. Several composts and their water extracts were investigated on different plant diseases especially on those caused by soil-borne pathogens all over the world. The mechanisms are not fully understood. Disease suppression by compost and compost extract is attributed to various mechanisms like the presence of antagonistic microbes and unidentified chemical factors, induction of systemic resistance in plants. Probably the components of the studied substances trigger chemical and biological factors in plants. Fusarium species cause wide spectrum of plant diseases, therefore studies of their control are the hot spots of the researches. The control of Fusarium spp. was investigated in the processed literature based on the possible mode of action of composts or compost extracts in various experimental conditions as in vitro, greenhouse, pot and field experiments. The results proved to be very promising so far. In this respect, compost and compost tea could be possible alternatives to the synthetic chemical pesticides in controlling plant pathogens in a more environmentally sound way.
Development of a geo-information system for monitoring the attractiveness of municipalities using parametric, structural approaches (case of Republic of Bashkortostan)
Authors: Hristodulo Olga Igorevna , Akhmetzianova Miliausha Ilgamovna
Published: December 2021

To date, one of the most important tasks of the State in ensuring the sustainable socio-economic and demographic development of the country is the regulation of migration processes. In the Republic of Bashkortostan in recent years there has been an increase in the number of people participating in both intraregional and extra-regional migration, which indicates the need to manage migration flows for the effective development of territories of this entity. In this connection, this article is dedicated to the development of GIS monitoring of the attractiveness of municipalities of the Republic of Bashkortostan, aimed at improving the effectiveness of decision-making in formulating migration policies in the region, based on a systematic combination of parametric and structural approaches. In the course of the study the analysis of existing approaches applied in this subject area, the methodology for determining the attractiveness coefficient of municipalities of the Republic of Bashkortostan was developed, A functional and information model for monitoring the attractiveness of municipalities has been developed, and a logical structural model of GIS monitoring the attractiveness of municipalities of the Republic of Bashkortostan has been built.
Endodontic Management of a Maxillary Lateral Incisor with Dens Invagination and Periapical Lesion: A Case Report and Mini Review of the Literature
Authors: Bolhari Behnam , Noori Faranak , Assadian Hadi
Published: December 2021

Dens invagination (DI) is a dental anomaly that can cause pulpal and periapical pathoses of the affected tooth. We describe the treatment of a healthy 18-year-old female with a chief complaint of recurrent facial swelling pertaining to a peg-shaped maxillary lateral incisor with DI. Examinations showed necrosis of the involved tooth with symptomatic apical periodontitis. Cone-beam computed tomography corresponded to Oehlers type II DI. Orthograde endodontic treatment was performed. To completely debride the canal and resolve the persistent purulent discharge, various methods and medicaments were used in separate sessions including passive ultrasonic activation of 5.25% sodium hypochlorite solution, calcium hydroxide mixed with 2% chlorhexidine, and double antibiotic paste as intracanal medicament. After resolution of the symptoms, the root canal and the invaginated space were filled by a mineral trioxide aggregate plug and backfilled with thermoplasticized gutta-percha. At the one-year follow-up, complete bone healing was noted in the affected periradicular area.
Integration of Oral Health Interventions in the Health Promoting Schools Program in Iran: A Multi-Stakeholder Feasibility Assessment
Authors: Rostam Beigi Morteza , Gholami Mahdia , Jafari Ahmad
Published: December 2021

Objectives: Based on the recommendations of the World Health Organization, we investigated the feasibility of oral health interventions (OHIs) as part of Health Promoting Schools (HPS) program in Karaj city elementary schools.
Materials and Methods: OHIs were accepted to be integrated into the components of HPS program by using the nominal group technique (NGT) and semi-structured interviews. Three NGT meetings were held with the faculty members of the School of Dentistry, Tehran University of Medical Sciences, and Karaj elementary school health care providers. Semi-structured interviews were held with school health executives of the Ministry of Health and Medical Education. The expert panel edited the OHIs and corrected the fragmentations, overlaps, and duplications. OHIs were sent to 24 individuals in six multi-stakeholder groups (faculty members of pediatric dentistry and community oral health departments, elementary school administrators, executive managers of Ministry of Health and Medical Education, elementary school dean and school healthcare providers). They were asked to score the feasibility of each intervention on a scale of 0 to 10.
Results: Based on the mean score of feasibility (threshold: 8) the OHIs were divided into two groups of feasible and infeasible. Eighty-six interventions were feasible, with a total mean score of 8.83±0.59 out of 10. The highest feasibility score was related to “comprehensive school health education”.
Conclusion: Integration of OHIs in HPS program is acceptable and feasible. The results can help policy-makers support the integration of OHIs in HPS program and encourage them to implement the program at the national level.
Identifying Factors Affecting Sustainability Reporting of Pharmaceutical Companies: Application of Delphi and Analytic Network Process based on Fuzzy DEMATEL
Authors: Esmaeilzadeh Habibollah , Ghodrati Hasan , Jabbari Hossein , Arabzadeh Meysam
Published: December 2021

Background: Today, one of the most important concerns in the pharmaceutical industry is achieving sustainability, and the pharmaceutical industry is recognized as a leading sector in corporate sustainability reporting. The purpose of this study was to identify, extract, prioritize and analyze the social factors and corporate characteristics which are effective in the sustainability reporting of Iranian pharmaceutical companies.
Methods: This was a cross-sectional study conducted in autumn 2020. The expertise and availability principles were used for sampling, and the snowball sampling method was used for sample selection. In order to identify and extract effective social factors and corporate characteristics, the method of content analysis and the study's review of literature have been used. The survey was conducted on 40 experts in the field of research using a researcher-made questionnaire. In order to purify the effective factors, Delphi method and the Analytic Network Process method based on Fuzzy DEMATEL were used.
Results: In terms of a strong interaction, the criterion for university-industry collaborations came first, and the criterion for sustainable innovation and cooperation with other companies came next. In this study, profitability, research and development intensity and the financial leverage were considered to be weak causal variables and sustainability reporting, an effect variable.
Conclusion: The results showed that Iranian pharmaceutical companies, in order to achieve the goals of sustainable development, should emphasize the continuous and regular presentation of annual sustainability reporting, and in this regard, key factors such as the criteria of university-industry collaborations, sustainable innovation and cooperation with other companies should be considered critical priorities.
Developing a Medical Tourism Marketing Model by a Meta-Synthesis Method
Authors: Pashaeifar Alireza , Ramezani Mojtaba , Janati Ali , Alavi Matin Yaghoub , Bodaghi Khajeh Noubar Hossein
Published: December 2021

Background: Today, medical and health tourism is one of the most promising sectors in the tourism industry in the world, which has led the organizations involved ,and the countries interested in developing tourism ,to focus their attention on this aspect of the tourism industry and plan for it. Hence, the aim of this study was to design the marketing model of medical tourism using meta-synthesis method.
Methods: The present study was designed as a meta-synthesis research in several stages for East Azerbaijan Province, Iran. Accordingly, after identifying the categories, concepts and marketing codes of medical tourism and evaluating its validity and reliability, the initial conceptual model of the research was formed. Out of 100 retrieved studies, 8 studies completely related to the purpose of the study were included in final analysis. In order to present the marketing model of medical tourism, the qualitative research method of meta-synthesis,s Sandlowski and Barroso (2006) was used.
Results: The conceptual model in the present study consists of 5 dimensions, 10 components and 40 indicators which can show the marketing model of medical tourism. 5 main dimensions included; quality of medical and tourism services, price of medical and tourism services, development of tourism and medicine, medical and tourism facilities and equipment, and information and communication technology.
Conclusion: The results of the research show that the dimensions, components and indicators extracted from the meta-synthesis method are approved by the panel of experts. The findings provide a new model and perspective on how to market medical tourism for the Iranian tourism industry, which will help managers, planners and policy makers of the healthcare system.
The healing-growth future of humanity: regenerative politics and crealectic care
Authors: De Miranda Luis
Published: December 2021

The 2020 coronavirus pandemic served to remind us that despite our Cartesian fantasies of control, naturing nature (natura naturans) is still active in the form of an untamed Other. The dominant reaction on most political sides was anthropocentric: if we do something– a doing generally framed within the scope of technique and management – nature shall go back to the kind and submissive non-viral neutrality that we appreciate in ‘her’ as a supposedly passive resource for productivism. How could humanity – a pandemic species itself and not only metaphorically – be better attuned with the powers of naturing nature, in a posture of co-creation rather than of a reactive technocratic war against the non-periodic or ‘monstrous’ aspects of life? This question is a matter of philosophical health: the future of humanity does not depend on statistics and logistics, but on the possibility of a philosophical (re)generative politics, a trustful care for creative singularity rather than an anxious control and production of regularity. Humanity’s collective health presupposes this reconciliation with naturing nature and the deployment of a global shared cosmology based on the creative healing-growth flux of originative creativity. This regenerative and life-affirming creative Real is here termed ‘Creal’, and we call ‘crealectics’ the generative philosophical health that favours healing growth.
Inspección inteligente de líneas de alta tensión con drones
Authors: Meza-Mora Javier A. , Gómez-Astúa Adolfo , Prado-Mora Alejandro
Published: December 2021

Las líneas eléctricas recorren todo tipo de terrenos, incluso algunos no accesibles por tierra, por lo que este mantenimiento se lleva a cabo usando helicópteros y vehículos todo terreno, sin dejar de mencionar un peligro inherente para las personas que en tierra o escalando la infraestructura requieren muchas veces tener riesgosos movimientos que realizar en campo y en la misma infraestructura,  lo que lo hace costoso, lento e ineficiente considerando que las líneas eléctricas se tienden por miles de kilómetros. El mantenimiento en líneas eléctricas de transmisión es un trabajo necesario para brindar un servicio de calidad, actualmente presenta ciertas limitaciones ya que es un trabajo riesgoso. Utilizando cámaras termográficas, lentes de zoom óptico, aeronaves no tripuladas podemos obtener la información necesaria sin necesidad de cortar la electricidad.
MANIF ESTAT ION OF THE ORAL MUCOSA DISEASES IN PATIENTS WITH COVID-19
Authors: Makedonova Yu. A , Poroisky S. V , Gavrikova L. M , Afanaseva O. Y.
Published: December 2021

In connection with the spread of the new coronavirus infection, the number of the oral mucosa diseases caused by COVID-19 is also growing. Effective diagnosis and rational pharmacotherapy of the oral mucosa pathology caused by COVID-19 is actual problem for dentists. In this work, on the basis of clinical and laboratory methods, diagnostics and treatment of the oral mucosa diseases were carried out in 43 patients who had previously undergone COVID-19. Oral examination results in patients with COVID-19 show a variety of oral manifestations. The obtained data substantiate the necessity and advisability of including a dental examination in this category of patients after their clinical recovery.
PREVALEN CE OF CALCAN EAL SPU RS IN PATIENTS WITH FLATFOOT DEFORMITY
Authors: Zhulikov A. L , Malanin D. A , Abuzyarova Yu. N , Finageev S. A , Shkoda D. A
Published: December 2021

The article focused on the problems of calcaneal spur development, diagnosis and its treatment options. Plantar calcaneal pain (calcaneal spur) is caused by proximal plantar fasciitis induced by degenerative and dystrophic changes of plantar fascia at the site of its attachment to the calcaneal bone, which is seen in young and middle-aged patients. The prevalence of calcaneal spurs in patients of different ages with flatfoot deformities is analyzed in the article. The study involved 411 patients aged 20-74, including 150 males (36,5 %) and 261 females (63,5 %). Flatfeet were revealed in 398 patients (96,8 %). Calcaneal spurs were detected in 6 % of patients with flatfeet. In males and females aged 20-44 this indicator was 12,5 % and 16,6 %, respectively, which is slightly lower than that shown by official statistics. The patients with calcaneal spurs participated in a survey, which employed the FHSQ scale comprising 13 questions divided into 4 groups: foot pain (4 questions), foot function (4 questions), footwear (3 questions) and general condition of feet (2 questions). 8 people (33,3 %) agreed to participate in the survey, 15 patients (67,7 %) refused to participate for no valid reasons. Out of 24 patients with calcaneal spurs, 6 (25 %) patients reported enhanced quality of life, 2 (8 %) reported no changes. Therefore, we may conclude that foot orthotics using individual corrective insoles and optimization of the functional foot load on feet and overlying portions of the locomotor apparatus play an important role in reaching positive outcomes when treating plantar fasciitis.
THE PRIMARY CHARACTERISTICS OF CHILDREN WITH PCR-CONFIRMED COVID-19 IN VOLGOGRAD REGION
Authors: Kaplunov K. O , Kramar L. V , Shishimorov I. N , Zayachnikova T. E
Published: December 2021

The article presents clinical and epidemiological characteristics of children 0-16 years old with a laboratory confirmed diagnosis of COVID-19, hospitalized in the state children's infectious clinic in April-August 2020. The diagnosis was verified by nucleic acid amplification: isolation of SARS-CoV-2 RNA by polymerase chain reaction (PCR) from the upper respiratory tract mucosa. The study did not include non-hospitalized patients. The authors highlight some features of the clinical symptoms of the nosology in question in childhood, and show the compliance of therapeutic and diagnostic techniques used in inpatient treatment with the requirements of regulatory documents.
Principles of Providing Nutrition to People Living with HIV/AIDS : a Literature Review
Authors: Kurniawati Ninuk Dian , Septiana Adi Sukma , Iqbal Muhammad , Sholihah Laely , Ciptaningrum Dyah Sekaringtyas , Retanubun Yulita Thadea
Published: December 2021

Introduction: Inadequate nutritional status in a person with HIV-AIDS (PLWHA) has a high risk of declining health in general. If a person is infected with HIV but has a good nutritional status, his immune system will be better than someone who is infected with HIV but has poor nutritional status. With good nutritional status, it can prevent HIV disease from entering the AIDS stage. Malnutrition that occurs in a person with HIV/AIDS can accelerate the progression of HIV disease and hinder treatment, thereby worsening the patient's condition. The use of Antiretroviral (ARV) has an effect that can worsen a person's condition if it is not accompanied by good nutritional intake.Methods: The method used in this study is a literature review with predetermined inclusion and exclusion criteria. Sample: The total number of samples obtained from the results of the literature review is 128 respondents. The instrument used in evaluating the research is using an instrument from The Joanna Briggs Institute (JBI). Results: Protein-energy enriched macronutrient supplementation along with ARV initiation was effective in improving physiological nutritional status and immune response in PLWHA.Conclusion: This can prevent people living with HIV from experiencing malnutrition and wasting, can restore the ideal body weight, increase and maintain the body's ability to fight various opportunistic infections, increase the effect of drugs, and can improve and improve the quality of life of PLWHA patients
Talent Management Practices on Employee Turnover Intention
Authors: Rumawas Wehelmina
Published: December 2021

Human resource managers need to play critical roles to overcome the talented and younger employees' turnover intention in an organization. This study aims to determine the causal relationship between talent management practice, perceived organizational support, and employee engagement and the impact on the turnover intention of Generation Y employees. A convenience sampling technique was used for this research. The study surveyed 182 Generation Y employees. The data collected were initially analyzed using the PLS-SEM method with the smartPLS-3 software. The results showed that talent management practice has a significant effect on perceived organizational support and employee engagement. It is also inferred that talent management practice, perceived organizational support, and employee engagement has a significant negative effect on turnover intention. This study also confirms that perceived organizational support has a significant positive effect on employee engagement. Additionally, this study discovered that perceived organizational support and employee engagement operate as mediators between talent management practices and turnover intention.
SOCIAL, CULTURAL, AND RELIGIOUS ASPECT IN MOSQUE FUNDRAISER
Authors: Irsyadi Achmad Naufal , Hanifiyah Fachriana , Suryadi Suryadi
Published: December 2021

Abstract: This study described and analyzed the form and types of speech in fundraising activity as well as to identify social, cultural, and religious aspect in it. The observation was carried out in Wirolegi Village, Sumbersari District, Jember Regency. This study used a phenomenological perspective which viewed that fundraising activity was a social reality known by the public. This study used anthropolinguistic approach which viewed that people's linguistics activities (speech) were related to the social and cultural systems of the community. To examine the forms and types of speech, this study used Searle's speech act theory. This study resulted a finding that the utterances of the fundraiser were about expressive and commissive speech acts. Thus, the language activity within fundraising program was an action that was clearly and indirectly contained in his speech. In its social aspect, the speech contained a binding from the speaker to the interlocutor which could contribute to their social and religious aspect.
Good Visual Acuity Outcome from an Ocular Blast Injury with Proper Management in Dr. Soetomo General Hospital Surabaya, Indonesia
Authors: Nurfahri Rifat , Lutfi Delfitri , Zuhria Ismi
Published: December 2021

Introduction: Ocular blast injury related to fireworks most often causing corneal erosion (29%), conjunctival erosion (11%), and conjunctival foreign body (10%) with children are more often than adults (65.9%:34.1%), and males far more often than female (71.9%:28.1%). Knowing proper management is very important to achieve the best result. Case presentation: We describe an ocular blast injury that experienced broad erosion and multiple foreign bodies on the corneal and pericorneal surface in the left eye and visual acuity decreased. The foreign body was scattered, and the fluorescein test was positive. We did proper foreign body extraction, irrigation, and ocular bandage. It was treated with chloramphenicol 0.5% eye ointment and homatropine eye drop. In two months, the patient’s left eye had clear cornea with a small scar formation near the visual axis. The visual acuity was 6/7 and BCVA was 6/6 with S-0.5 C-0.5 A 50° correction. Conclusions: Patients with ocular blast injury limited to superficial cornea erosion and and conjunctival erosion have a reasonable probability of achieving the best visual acuity. Foreign body extraction, proper irrigation, and topical medication show promising results. Scar formation near the visual axis can disrupt visual acuity however can be corrected in this case it can be corrected with glasses. Furthermore, public promotion and regulation to control firework using are very important.
A Challenging Management of Pseudomonas Perforated Corneal Ulcer with Multilayer Amniotic Membrane Transplantation and Pericardial Patch Graft in Pediatric Patient
Authors: Afifah Nabilah , Putranto Herwindo Dicky , Wulandari Lely Retno
Published: December 2021

Introduction: Pseudomonas aeruginosa (P. aeruginosa) is the leading cause of corneal ulcers in children 0 to 3 years of age compared to children in general. Case presentation: A two-months-old infant presented with whitish patches on the right eye two days before admission. A central corneal ulcer with a size of 7-mm x 7-mm accompanied by corneal thinning and melting was shown on the right cornea. It is was surrounded by greyish white creamy infiltrates. Corneal scraping showed Pseudomonas aeruginosa specimens. The cornea became perforate and crystalline lens extrusion was found at the day after intravenous ceftriaxone, levofloxacin eye drop, and cefazoline fortified eye drop administering. It might be caused by bacterial elastase and toxin which contributed to corneal damage. The patient was underwent a multilayer Amniotic Membrane Transplantation (AMT) combined with a pericardial patch graft due to corneal perforation. Two months post-AMT and pericardial patch graft the corneal perforation became entirely heal due to multilayer AMT, despite lysis of the pericardial patch graft. Corneal scar formation and reduction of vitreous opacity in ultrasound examination were shown. The patient was planned to undergo keratoplasty. Conclusions: Corneal ulcers due to Pseudomonas aeruginosa are highly destructive. The levels of infection, diagnostic, and therapeutic are still problems in pediatric patients. Lens extrusion and lysis of the pericardial patch graft are examples in this case. Keratoplasty is the definitive treatment for corneal ulcers with perforation; however, multilayer AMT combined with pericardial patch graft can be used as an alternative therapy to accelerate wound healing, reduce inflammation, and maintain the integrity of the eyeball.