bluuebunny/crossref_metadata_2025 huggingface dataset:
Pengaruh Tutupan Hutan dan Lahan Terhadap Sektor Pertanian dalam Perekonomian Pendapatan Daerah: Studi Di Provinsi Lampung
Authors: Syahputra Aldy Mega , Bakri Samsul , Qurniati Rommy
Published: June 2022

Deforestation and land cover changes are the upstream causal of the environmental performance and welfare, namely starting from declining hydro-orological functions, increased microclimate fluctuations, the emergence of shocks to the ecological balance, declining agricultural yields, declining incomes, further suppressing economic growth in the agricultural sector, which is generally followed by downstream sectors. The research was conducted in May - December 2020. The linear model postulate was applied at 5% and 10% significant levels with the response variable in the form of income from agricultural sector which was acquired from the BPS website, then optimization using Minitab. While the explanatory variables used are the proportion of land cover classes. Land and forest cover data were identified through the interpretation of Landsat satellite imagery downloaded from the NASA website using ArcGIS and Ecognition, then validation tests carried out with field exploration of the land cover class. The results of the research showed the relationship between the model equation R-Sq (adj) = 77.9% and the impact that occurred in each land cover class for each 1% decrease. Changes in the area of state forests, community forests, plantations, rice fields have an impact on decreasing the income of the agricultural sector respectively (IDR Million) 35.3; 16.7; 48.7; and 10.0. It suggest that conduct research on downstream economic activities such as inland fishery production, hydropower, industry, and trade.
THE CONCEPT AND SIGNIFICANCE OF CONSTITUTIONAL AND ORGANIC LAWS IN LEGAL SCIENCE AND LEGISLATION OF DIFFERENT COUNTRIES
Authors: Kunenko Iryna S , Poliarush-Safronenko Svitlana O , Lapka Oksana
Published: June 2022

The article is devoted to the analysis of the concepts of “constitutional law” and “organic law”, to identify the features of these types of laws in modern legal systems. It is determined that in different countries the terms “constitutional law” and “organic law” are widely used in legal science at both the doctrinal and legislative levels. Due to the elaboration of scientific works, a number of textbooks and manuals, a theoretical analysis of this issue was carried out, an analysis of scholars' opinions on the understanding of the terms “constitutional law” and “organic law” was carried out. The constitutions and other legal acts of different countries in which these concepts are reflected are analyzed. The content and main features of this type of law are described. The place of the mentioned laws in the system of legislation of different countries is determined. The differences of their acceptance and application in world practice are revealed. Recommendations are made to distinguish between the concepts of “constitutional law” and “organic law”.
EMPLOYING THE WRITER’S VOICE FOR IMPROVING THE WRITING ABILITIES OF THE SAUDI EFL LEARNERS
Authors: Alshammari Hammad
Published: June 2022

This qualitative study aims at highlighting the possible underlying reasons of the Saudi EFL learners’ poor writing abilities. It also attempted to conceptualize the perceptions of university professors and Saudi EFL learners toward their current writing challenges. To achieve this purpose, three instruments namely, a) an in-depth interview, b) survey, and c) a discourse analysis of an EFL learners’ writing sample were conducted. The sample of this study consisted mainly of (5) university professors and (50) EFL learners selected conveniently from one of the Saudi northern universities. The qualitative analysis of the collected data revealed that the low writing performance of the EFL learners was attributed to their low motivation, poorly constructed self-confidence, the focus on testing and frequent focus on correctness. It was also indicated that “unrelated” or “uninterested” writing topics for learners contributed to their poor writing proficiency levels. This study hypothesizes that exposing EFL learners to more free writing tasks that help them express their own voice, thoughts, ideas, persona, identity, etc would help them improve their writing abilities considerably. It also found that limited vocabulary, testing anxiety, poor instructional practices, and inter alia were the primary themes that led to poor writing skills of learners. This study recommends language instructors to focus more on fluency without fully discarding correctness as well as including humor, identity and ‘self’ concepts in teaching writing.
The biochemical status of cows during the therapy of subclinical ketosis using natural zeolites and lecithin
Authors: Novikova I. A. , Dolgaya M. N.
Published: June 2022

Relevance. Ketosis is a frequently observed disease in cattle, which is especially susceptible to highly productive cows after calving, and therefore the search for affordable and effective methods for the prevention and correction of this condition is actively pursued.

Materials and methods. The biochemical parameters of the blood serum of Blackand-White cows with subclinical ketosis treated according to schemes that included propylene glycol, natural zeolites of the Khotynets deposit, and lecithin were studied. The biochemical composition of blood serum and the activity of enzymes in it were investigated in 4 groups of newly calved cows: 1 — clinically healthy (control); 2 — animals with subclinical ketosis which received 250 ml of propylene glycol 2 times a day for 7 days; 3 — animals with subclinical ketosis which received 250 ml of propylene glycol 2 times a day for 7 days and zeolites in the amount of 3% of the dry weight of the feed for 21 days; 4 — animals with subclinical ketosis which received 250 ml of propylene glycol 2 times a day for 7 days, zeolites in the amount of 3% of the dry weight of the feed and 15 g of lecithin per 100 kg of live weight for 21 days.

Research results. It was found that the restoration of the parameters of the biochemical composition of the blood serum of diseased cows to the levels of clinically healthy animals had been achieved on the 22nd day of therapy with the combined use of propylene glycol, natural zeolites and lecithin. The exception was the glucose content, which remained significantly increased by 14.0% compared to the control. The advantage of a complex treatment scheme over the main therapy used on the farm with the use of only propylene glycol is expressed in a significant increase on the 22nd day of the experiment in the blood serum of total protein by 7.0%, urea — by 17.5%, a decrease in cholesterol concentration by 29.0%, total bilirubin — by 27.5%, AST enzyme activities — by 31.9% and LDH — by 28.5%.
Indicators of antioxidant protection of the body of dairy cows depending on the phase of lactation and physiological state
Authors: Bogolyubova N. V. , Rykov R. A.
Published: June 2022

Relevance. Studies on the assessment of the pro- and antioxidant status of the body of productive animalsare relevant, since they are interconnected with health, the state of the immune and reproductive systems. There is a steadily growing body of information in the field of oxidative stress in animal husbandry and veterinary medicine, which indicates the general importance of antioxidant defense of the body with impaired health and productivity of ruminants. There is a growing need to translate this knowledge into practical proposals for livestock specialists and veterinarians.

Methods. In order to study the indicators of antioxidant protection in the body of dairy cows depending on the month of lactation and the physiological state, the following groups of cows were formed in the conditions of the PZ Ladozhsky (Krasnodar district) in the winter period of 2021: dry; lactating: 1 month; 2 months; 3 months; 4 months; 5 months; 6–7 months. The following indicators were determined in the blood of the studied animals: the concentration of ceruloplasmin, products reacting with thiobarbituric acid, the total content of water-soluble antioxidants, the general antioxidant status, and the antioxidant activity of blood serum.

Results. The results obtained indicate changes in the antioxidant status in the body of cows, depending on the physiological state and month of lactation. By 5–6 months of lactation in the blood of cows the maximum levels of accumulation of LPO products are observed and the level of ceruloplasmin decreases, and the maintenance of the overall antioxidant status is carried out at the expense of other water-soluble antioxidants. The most significant changes in the studied parameters are observed between dry and lactating cows. The results obtained will allow monitoring the health status of animals and will serve as the accumulation of a database for the development of reference values for indicators of the antioxidant status in the body of dairy cows, depending on the physiological state and phase of lactation.
The influence of targeted selection on the exterior and productive indicators of Stavropol sheep in the dry steppe zone of the Volga region
Authors: Lakota E. A. , Vorontsova O. A. , Zamygin S. N.
Published: June 2022

Relevance. Purposeful selection contributes to obtaining the optimal type of sheep of the Stavropol breed with improved exterior and productive parameters in the steppe conditions of the Volga region.

Methods. The experiment took place in the CJSC “New Life” of the Novouzensky district of the Saratov region. The research material is purebred sheep of the Stavropol breed. Formation of experimental groups of queens (3): during selection into constitutionally productive types, an eye-dimensional assessment of external forms was used, which was specified by the measurements of body articles, live weight. In the first group were selected queens with a deviation to the strong type of constitution, in the second — to the gentle, in the third — to the loose. They mated with strong-type tups.

Results. The offspring were formed: group I — from strong queens, II — tender, III — loose types. At birth, group III ewes had an advantage over I by 1.70%, over II — by 7.47%. Group I was superior in live weight to group II by 5.67%. In 4.5 months, “loose x strong” offspring exceeded “strong x strong” by 2.43%, “tender x strong” — by 12.27%. “Strong x strong” had an advantage over “gentle x strong” by 9.61%. According to the exterior at birth, the descendants of “loose x strong” surpassed “strong x strong”, “tender x strong” in chest width by 19.52; 5.78%; chest circumference — by 6.08; 10.99%, “strong x strong” prevailed over “gentle x strong” in chest width by 32%; chest circumference — by 4.62%. The trend of changing body measurements was observed at 4.5 monthsas well. According to the downness index at birth, “tender x strong” exceeded “strong x strong”, “loose x strong” by 8.03; 9.12%, at 4.5 months “strong x strong” had superiority over “tender x strong”, “loose x strong” by 3.77; 4.77%. All the young animals inherited the constitutional and productive characteristics of their parents, which is important in the inbreeding selection of sheep of the Stavropol breed in the Volga region.
Small-flowered clematis collections of the Stavropol Botanical Garden
Authors: Chebannaya L. P.
Published: June 2022

Relevance. The biological features were studied, the average dates of the beginning, end and duration of the phenological phases of growth and development of species, forms and varieties of the genus Clematis (Clematis L.) were established. The assortment of small-flowered clematis for cultivation in the soil and climatic conditions of the Stavropol upland, characterized by high decorative properties, resistance to drought, pests and diseases, is highlighted.

Methods. The object of research is small-flowered species, forms and varieties of the genus Clematis L., cultivated in the collection of the Stavropol Botanical Garden. The studies were conducted in 2012–2021 according to the methods of variety study and evaluation of the decorative qualities of clematis species and varieties.

Results. The dates of the beginning and end of the growth of shoots are determined. According to the duration of shoot growth, all taxa are divided into groups: with a short growth period (38–51 days), medium (60–79 days); long (90–126 days). According to the timing of the beginning of flowering, the studied taxa are classified into five groups, most of them are included in the groups of early summer and summer flowering. According to the duration of flowering, three groups are distinguished — with short flowering, up to 30 days (C. jubata Bsch., C. recta L., C. recta f. atropurpurea, C. terniflora DC.); medium, from 41 to 60 days (С. fusca Turcz., C. ‘Bryzgi Morja’, C. integrifolia L., C. orientalis L., C. serratifolia Rehder, C. tangutica (Maxim.) Korsh., C. virginiana L., C. viticella L., C. viticella f. rosea); long-lasting, more than 60 days (C. ‘Fargesioides’, C. heracleifolia DC., C. hexapetala DC.).
Fatores Prognósticos e Funcionalidade na Síndrome de Compressão Medular Metastática: um Estudo de Coorte
Authors: Faria Eduarda Martins de , Araujo Bianca Paraiso de , Chelles Patricia Almeida , Giglio Alessandra Grasso , Fabro Erica Alves Nogueira , Bizzo Luciana Velasco , Bergmann Anke , Thuler Luiz Claudio Santos , Silva Gustavo Telles da
Published: June 2022

Introdução: A síndrome de compressão medular metastática (SCMM) tem grande potencial de perda irreversível da função motora e sensitiva, sendo considerada uma emergência oncológica. Objetivo: Avaliar o prognostico da SCMM e a funcionalidade dos pacientes com tumores sólidos. Método: Estudo de coorte que incluiu pacientes com câncer que desenvolveram SCMM entre janeiro de 2017 e dezembro de 2018. Os dados clínicos e sociodemográficos foram extraídos dos prontuários físicos e eletrônicos. Analise de sobrevida foi realizada pelo método Kaplan-Meier. Resultados: O estudo abrangeu 90 pacientes que apresentaram SCMM. Ao diagnostico da SCMM, 55,5% dos pacientes não conseguiam realizar marcha. Os pacientes com SCMM após câncer de pulmão tiveram 4,1 vezes maior risco de morrer (IC 95%, 1,79-9,41; p=0,001), os pacientes com tumores geniturinários tiveram 1,9 vezes maior risco de morrer (IC 95%, 1,06-3,45; p=0,02) e os pacientes com outros tipos de tumor tiveram 3,1 vezes maior risco de morrer (IC 95%, 1,58-6,24; p=0,001) quando comparados aos pacientes com SCMM após câncer de mama. Conclusão: Destaca-se a relevância clinica deste estudo ao descobrir que o tipo de tumor primário e um fator preditor independente para sobrevida da SCMM. Ao diagnostico da SCMM, mais da metade dos pacientes não realizam marcha.
Covid-19 Salgını Sürecinde Evin Kullanımına İlişkin Sosyolojik Bir Analiz
Authors: KARAKAŞ Mehmet , SALA Bedir , AYKUT Gözde , BOZKURT Recep , DİLEKLİ Zeynep , GENCER Murat
Published: June 2022

Ev, insanların barınma ve hayatlarını devam ettirme gibi temel ihtiyaçlarını karşılayan özel bir mekândır. Covid-19 pandemisiyle birlikte insanların daha çok vakit geçirmek zorunda kaldıkları ev, eğitim ve çalışma gibi sosyal etkinliklerin yürütüldüğü ve gündelik hayatın merkezine yerleşen bir mekâna dönüştü. Bu çalışmanın amacı da pandemi sürecinin evdeki yaşamı, ilişkileri ve evin kullanımı üzerinde nasıl bir etki oluşturduğunu incelemektir. Bu bağlamda evin değişen kullanımı, eve yüklenilen yeni anlamlar, evdeki aile ilişkileri ve sosyal medya kullanımının bireylerin ilişkilerini ve sosyalleşmelerini nasıl etkilediğine odaklanarak pandemi sürecinde evin sosyolojik bir analizi yapılacaktır. Yöntem olarak nicel araştırma tekniği kullanılarak yürütülen çalışmada veri toplamak için nicel araştırma tekniklerinden biri olan anket tekniği kullanılacaktır. Türkiye’de 18-65 yaş aralığındaki bireylerden anket tekniği ile toplanan veriler SPSS programı kullanılarak analiz edilecektir. Araştırma evrenini temsil eden toplamda 600 kişiden veri toplanmıştır. Araştırmanın temel bulguları ise pandemi sürecinde zamanlarının çoğunu evde geçiren bireylerin eve ilişkin algıları ve pratiklerinin değiştiği, aile içerisinde politik ve dini tartışmaların arttığı, uzun süre evde kalmanın çeşitli konularda kaygıya yol açtığı, geleneksel kadın ve erkek rollerinde bir değişimin ortaya çıktığı görülmektedir. Pandemi sürecinde özellikle internet ve telefon kullanımındaki artışla beraber sosyal medya kullanımının arttığı, bu durumun evi daha katlanılabilir hale getirdiği de bulgular arasındadır.
Organizational Conflict and Psychological Well-Being Relationship: The Moderating Effect of Workplace Ostracism
Authors: KILINÇ Erman , DOĞAN Edip
Published: June 2022

The purpose of this study is to determine the relationship between organizational conflict and the psychological well-being of employees and to test the moderating role of workplace ostracism in this process. We distributed the questionnaires to 811 individuals working in the public and private sectors in Turkey through simple random sampling. 425 persons participated in the questionnaires. We didn’t assess 16 questionnaires because the participants didn’t respond from start to finish. Thus, we evaluated 409 questionnaires and tested them according to the purpose of the research. We used the IBM SPSS v26, Lisrel 10.20 programs, and Process Macro v3.3 plug-ins for data analysis. According to the results of the analysis, we can see that organizational conflict and ostracism in the workplace have a negative impact on psychological well-being. We have also proven that workplace ostracism moderates the relationship between organizational conflict and psychological well-being. In the conclusion section of the study, we have compiled the results of the analysis and compared them with other findings in the literature. In the literature review, we noted that the moderating role of workplace ostracism in the relationship between organizational conflict and psychological well-being has never been studied. This study, therefore closes an important gap in the literature on organizational behavior.
The Component and Functional Pathways of Gut Microbiota Are Altered in Populations with Poor Sleep Quality – A Preliminary Report
Authors: Zhang Jianghui , Zhang Xueqing , Zhang Kexin , Lu Xiaoyan , Yuan Guojing , Yang Huayu , Guo Haiyun , Zhu Zhihui , Wang Tianli , Hao Jiahu , Sun Ying , Su Puyu , Zhang Zhihua
Published: June 2022

With the development of genome sequencing, many researchers have investigated the mechanism by which the intestinal microbiota influences sleep across the brain-gut axis. However, the relationship between gut microbiota and sleep disorder remains unclear. Thus, we studied the difference in gut microbiota composition between poor sleep quality- and normal populations, which helps set the ground for future research. The recruited college students provided baseline information and stool samples and completed the Pittsburgh Sleep Quality Index (PSQI). We compared the two groups’ gut microbiota composition and functional differentiation by using the 16S rRNA gene sequencing analysis. The main bacterial difference and the most critical effect were mainly concentrated within Tenericutes and Elusimicrobia. Compared with the healthy control group, some functions of the gut microbiota were impaired in the poor sleep quality group, such as butanoate metabolism and propanoate metabolism. Bacterial taxa with significant differences raised the possibility for future diagnosis and treatment of sleep problems.
Wohnungseigentumsrecht Handbuch für die Praxis
Authors: Tschütscher Joachim
Published: June 2022

Wohnungseigentumsrecht übersichtlich, praxisnah und in verständlicher Sprache Das bewährte Praxishandbuch beantwortet alle relevanten rechtlichen Fragen rund um die Eigentumswohnung. Die Kerngebiete des Wohnungseigentumsrechts werden systematisch und praxisnah dargestellt. Die Neuerungen der WEG-Novelle 2022 werden ausführlich erklärt. Besonderes Augenmerk wird gelegt auf: Beschlussfassung – Mehrheitsbildung – Beschlussanfechtung Änderungen des Wohnungseigentumsobjekts und allgemeiner Teile Abgrenzung ordentliche/außerordentliche Verwaltung/Erhaltung/Verbesserung Benützungsregelungen Pflichten des Verwalters Viele Beispiele und Praxistipps erleichtern das Verständnis und bieten Hilfe für die Lösung von Problemen des Wohnungseigentums. Zahlreiche Muster können als Vorlage für Briefe, Anträge, Beschlüsse und Vereinbarungen verwendet werdenund stehen auch online zum Download zur Verfügung. Ein ausführliches Sachverzeichnis ermöglicht den raschen und gezielten Zugriff.
Review of Sharia Economic Law on Termination of Agricultural Land Lease Contract in Alahan Panjang
Authors: Sari Fitri
Published: June 2022

This study aims to find out the economic fiqh review of the termination of agricultural land lease contracts in Alahan Panjang. Renting farmland is done during the growing season until the harvest season in Alahan Panjang. The formulation of the problem in this study is how the implementation of the termination of agricultural land lease contracts in Alahan Panjang and how the economic fiqh review of the termination of agricultural land lease contracts. This study uses field research with qualitative approach. The data was obtained through in-depth interviews. Based on the results of the study concluded the implementation of agricultural land lease contracts have not met the pillars and conditions, namely the unilateral termination of agricultural land lease contracts from Mu'ajir while the time agricultural land contract has not expired. Termination of this contract results in material losses for musta'jir. In this economic fiqh review is a bad habit or urf' fasid. There is no benefit of both parties in the termination of the land lease contract, because one of the parties feels harmed.
Auricular Reconstruction in Microtia Patients: A Single Institution Experience
Authors: Hur Young Kyun , Jeong Yeonsu , Kim Sung Huhn
Published: June 2022

Background and Objectives Microtia is a congenital deformity where the pinna and middle ear structures are underdeveloped. Auricular reconstruction in microtia is one of the most difficult surgeries in otolaryngology due to the complex three-dimensional structure of the auricle. This study investigated the post-operative results in total auricular reconstruction performed by otologic surgeons in a single institution.Subjects and Method We analyzed data from 27 microtia patients who underwent auricular reconstruction in our institution from 2011 to 2019. The post-operative results were evaluated in terms of the shape of the auricle, the symmetry of the ear, and the degree of auriculocephalic sulcus stricture. The type and frequency of post-operative complications associated with the reconstruction were also evaluated.Results Of the 24 patients, the shape of the auricle was good in 11 (40.7%), moderate in 11 (40.7%), and poor in 5 (18.6%) patients. The symmetry of the ear size was symmetric in 24 (88.9%) and asymmetric in 3 (11.1%) patients. The degree of auriculocephalic sulcus stricture was good in 11 (40.7%), partial stricture in 12 (44.4%), and severe stricture in 4 (14.8%) patients. Postoperative complications included skin necrosis, suture material exposure, and wound infection with cartilage deformation.Conclusion Total auricular reconstruction is a complex and sophisticated operation utilizing either autologous rib cartilage or artificial implant material. Considering that microtia is often accompanied by ear canal stenosis and hearing impairment, otolaryngologists should be more interested in the field of auricular reconstruction.
Acquired Atresia of External Auditory Canal Associated With Synovial Chondromatosis of the Temporomandibular Joint
Authors: Kim Soon-Joon , Kim Jae Hyun , Kwon Joong Keun
Published: June 2022

Synovial chondromatosis (SC) is a rare disease involving long bones, rarely affecting the temporomandibular joint (TMJ). It can manifest as preauricular swelling, pain, and joint dysfunction. This report represents the case of acquired atresia of external auditory canal in association with SC of TMJ. Active evaluation and treatment of TMJ pathology seem essential when addressing the acquired atresia of external auditory canal.
Epistemology of the current state of nature management as a causal pattern of land reform carried out so far in Ukraine
Authors: Kovaliv O. , Morozov O. , Lazarenko V. , Novalenko А.
Published: June 2022

Analyzed and generalized causal patterns as the main milestones of organizational and legal principles carried out by so far reform in Ukraine — from the point of view of its consequences, which made it possible to reveal basic knowledge for possible formulation on their basis of existing organizational and economic principles on the use of natural objects in Agrosphere. The existing knowledge of constitutional land pragmatism, which contributes to the true knowledge of various existing legislative and regulatory acts and organizational and economic principles of conducted transformations on the subject of their requirements of the constitutional essence and the needs of balanced use of natural objects, are investigated. The direction is disclosed as a conceptual approach to the possible functioning of the organizational and economic principles of balanced use of natural objects of Ukrainian agrospheres, which is based on a reliable legal basis and is realized through a comprehensive systemic «cognitive land economy» (author D.N., Alexander Koval) The process of relevant land reform in Ukraine as a new paradigm. It is found out that only based on the knowledge gained in the process of execution of the first stage of assessing the real state of use of natural objects in the agrosphere, as special causal laws from the position of the latest requirements of state formation, it becomes possible to carry out more thorough and productive research in the following stages. Implementation of fundamental scientific work «Organizational and economic principles of balanced use of natural objects in the agroosphere of Ukraine».
Prerequisites for creating the agricultural land resources monitoring system
Authors: Hutsuliak H. , Hutsuliak Yu. , Oliinyk H.
Published: June 2022

The article considers the problems of land monitoring in Ukraine as one of the main components of the environmental monitoring system and a means of control in the field of land use and nature management. There is a need to maintain the natural potential of the cultural landscape, preserve the natural fertility of soils and ensure the balanced development of agricultural production and nature management, and therefore there is a need for information on its condition to ensure its maximum diversity and differentiation, ie mosaic of its structural units.
It is proposed to create a monitoring system, which must be based on a single methodological basis and provide comprehensive research to protect the environment and create a policy that will form a highly productive system «man — nature».
Global guidelines for reporting on sustainability of enterprises in transition countries: martial law and reconstruction in Ukraine
Authors:   SESE “The Academy of Financial Management”, IEFYMENKO Tetiana , VOROBEI Svitlana ,   Ministry of Finance of Ukraine, LOVINSKA Ljudmyla ,   SESE “The Academy of Financial Management”
Published: June 2022

Introduction. The most important task of the sovereign state of Ukraine nowadays is the victory in the war with the Russian aggressor, as well as ensuring sustainable innovation development in close cooperation with the international community. Problem Statement. In countries with economies in transition in the preparation of non-financial reporting we can notice the following : lack of institutional levers of impact and motivation for the disclosure of environmental, social and other indicators; lack of standard approaches to the content of non-financial reporting and procedures for its administration, etc Purpose. The aim of the study is: to substantiate the improvement to Ukraine’s public policy in Ukraine on non-financial reporting on sustainable development; to study contradictions of the new reality and directions to overcome them for the countries with transition economies while preparing non-financial reporting and applying indicators of sustainable development; to develop proposals on the content of such reporting in emergency situations, in particular during hostilities, as well as post-war reconstruction. Materials and methods. The following methods: institutional, systemic, empirical, structural and functional and others have been applied while using UNCTAD guidelines and factual data., Results. The authors suggest ways to overcome these obstacles and to supplement the “Guidance on core indicators for entity reporting on contribution to the implementation of SDGs” (GCI) with a block of indicators on crisis management trends in conditions of uncertainty and post-war overcoming of the effects of destabilization. Conclusions. The martial law in the country, the consequences of hostilities have a profound impact on the activities of companies and should be shown in the reports. On the basis of regulatory initiatives of the European Union on non-financial reporting in the electronic format in Ukraine it is necessary: to regulate the Taxonomy of non-financial reporting (EU Regulation 2020/852); to show in the management report the disclosure of basic performance indicators of enterprises in various fields (economic, environmental, social, institutional); to implement the concept of sustainable development in the national non-financial reporting infrastructure.
Current trends of VAT harmonization in the EU countries
Authors:   West Ukrainian National University, VALIHURA Volodymyr
Published: June 2022

Introduction. Socio-economic realities related to VAT fiscal losses, the spread of the 2008 global financial crisis and the economic crisis caused by quarantine restrictions due to the spread of COVID-19 and the consequences of economic sanctions in response to Russia's military aggression against Ukraine have slowed VAT harmonization in the EU countries. Problem Statement. The study is devoted to the issue of establishing preconditions and assessing prospects for new initiatives related to VAT harmonization in the EU countries. Purpose. Coverage of retrospectives, current trends and assessment of prospects for further harmonization of VAT in the EU countries. Materials and Methods. The following general and special methods were used in the research process: analysis, synthesis, grouping, description, comparison, theoretical generalization and abstract-logical. Results. The legislative features of regulating VAT harmonization based on the EU Council Directives are emphasized. The directions of coordination of the VAT administration policy at the Community level are systematized. Retrospectives of forming approaches to establishing the principle of VAT collection, according to which trade in the EU countries should take place, are analyzed as well as indicators of gaps in VAT revenues in the EU countries. The essence of the finalized system of VAT administration in the EU, based on the principle of the destination country, is revealed and the prospects of its implementation are assessed. The peculiarities of the new rules of VAT collection on cross-border e-commerce transactions between business and consumers (B2C) are considered. The current trends in setting VAT rates in the EU countries are highlighted and the prospects for their further harmonization are outlined. Conclusions. The final decision on the introduction of a finalized VAT system for intra-EU trade depends on the effectiveness of VAT on cross-border e-commerce between business and consumers (B2C), which was introduced on 1 July 2021 and is determined by the impact of economic sanctions on the EU market concerning the Russian Federation. Changes in the taxation of e-commerce in the EU may cause the rejection of online marketplace customers from the goods of Ukrainian sellers, and the reorientation to European goods.
The input-output scheme of the economy of Japan: System analysis and modelling of the inter-branch relations of the Ukraine’s economy
Authors:   SESE “The Academy of Financial Management”, KULYK Volodymyr
Published: June 2022

Introduction. The scheme input-output, used for the study of inter-branch reproduction of the economy of Japan, on system analysis and modelling of inter-branch relations of the economy of Ukraine is considered. Problem Statement. The analysis and modelling of inter-branch relations of the Ukrainian economy is considered. The purpose is to prepare aggregated the input-output tables of the Ukrainian economy and conduct a systematic analysis and modelling of inter-branch relations of the Ukrainian economy according to the scheme used by the Government of Japan. Materials and Methods. The basis of the study was the official data of the State Statistics Service of Ukraine – the input-output tables in basic prices for 2013-2019. General scientific and special methods were used: analysis, synthesis, grouping, comparison, balance method, method of economic and mathematical modelling. Results. According to the scheme used in Japan, a scheme of the turnover of the Ukrainian economy has been prepared, which follows from the input-output table for 2019. On the basis of input-output table of Ukraine and national accounts (2013-2019), aggregated input-output tables of the Ukrainian economy of 13 types of economic activity and 3 large sectors of the economy in the form of primary, secondary and tertiary sectors were prepared. The aggregation of sectors of the economy of Ukraine is substantively consistent with the aggregation of industries in the 13 sectoral model of input-output of the Japanese economy. Input-output tables are prepared in a competitive-import version. On the basis of aggregated input-output tables was analysed the development of sectors of the economy of Ukraine during 2013-2019. The classification of industries into key ones, with direct and inverse impact , etc. was carried out. Structural changes in GDP by final costs, production method and income categories were analysed as well as coefficients of value added, imports, influence. A visual assessment of the volatility of the GDP structure was carried out. Conclusions. The analysis and modelling of inter-branch relations of the economy of Ukraine is carried out. A structural analysis of Ukraine's GDP within the framework of the prepared input-output table was carried out. Developments can be used for 1) scientific and educational purposes; 2) modelling of specific economic systems presented by the corresponding input-output tables; 3) conducting a comparative analysis of the economies of Ukraine and Japan within the framework of completely comparable the input-output tables.
Analysis of bankruptcy factors of large enterprises of Ukraine
Authors:   SI ", KERIMOV Pavlo ,   Institute for Economics and Forecasting of NAS of Ukraine"
Published: June 2022

Introduction. The results of the author’s previous study of financial position of large firms in Ukraine indicate an anomalously high percentage of zombie firms and firms with negative shareholder equity among them, which generally imply chronic solvency problems. Such firms, however, continue their existence for prolonged periods of time seemingly against creditors’ best interest, which, as presumed by the classic works of corporate finance, should initiate the bankruptcy procedure in order to minimize their losses. Problem Statement. Research into the motivation of Ukrainian creditors for initiating a bankruptcy procedure towards big industrial firms in Ukraine. Purpose. Determining factors which cause bankruptcies among large firms in Ukraine using econometric modelling. Materials and Methods. Logit regressions based on panel data of a selection of 286 predominantly large Ukrainian enterprises for 2006-2020. Results. The first, extended (32 independent variables), iteration of the model indicates that bankruptcy probability rises with the increase in off-shore capital and shareholder equity, as well as with the increase of accounts receivables and long-term bank loans. Bankruptcy probability drops with the increase in accounts payable for goods, works and services , all types of income, investments in fixed assets and depreciation. Abridged iteration of the model, which had all of the non-significant variables excluded, verifies the preliminary conclusions and allows to pinpoint less obvious factors: in particular, the probability of bankruptcy depends insignificantly on the performance of the enterprise. Conclusions. Probability of bankruptcy among big industrial firms in Ukraine is more dependent on the percentage of the off-shore capital they possess and their allegiance towards FIG, which, along with high percentage of related parties’ loans and the aforementioned extra-high percentage of zombie firms and firms with negative shareholder equity, indicates the non-market nature of credit relations with participation of such firms. Keywords: bankruptcy; bankruptcy
A Transendothelial Leukocyte Transmigration Model Based on Computational Fluid Dynamics and BP Neural Network
Authors: Chi Qingjia , Yang Zichang , Liang Hua-Ping
Published: June 2022

The mechanism of immune infiltration involving immune cells is closely related to various diseases. A key issue in immune infiltration is the transendothelial transmigration of leukocytes. Previous studies have primarily interpreted the leukocyte infiltration of from biomedical perspective. The physical mechanism of leukocyte infiltration remains to be explored. By integrating the immune cell transmigration computational fluid dynamics (CFD) data, the paper builds a time-dependent leukocyte transmigration prediction model based on the bio-inspired methods, namely back propagation neural networks (BPNN) model. The model can efficiently predict the immune cell transmigration in a special microvascular environment, and obtain good prediction accuracy. The model accurately predicted the cell movement and flow field changes during the transmigration. In the test data set, it has high prediction accuracy for cell deformation, motion velocity and flow lift forces during downstream motion, and maintains a good prediction accuracy for drag force. The two prediction models achieved the prediction of leukocyte transmigration in a specific microvascular environment and maintained a high prediction accuracy, indicating the feasibility and robustness of the BPNN model applied to the prediction of immune cell infiltration. Compared with traditional CFD simulations, BPNN models avoid complex and time-dependent physical modeling and computational processes.
Epiprofin Transcriptional Activation Promotes Ameloblast Induction From Mouse Induced Pluripotent Stem Cells via the BMP-Smad Signaling Axis
Authors: Miao Xinchao , Niibe Kunimichi , Fu Yunyu , Zhang Maolin , Nattasit Praphawi , Ohori-Morita Yumi , Nakamura Takashi , Jiang Xinquan , Egusa Hiroshi
Published: June 2022

The transcriptional regulation of induced pluripotent stem cells (iPSCs) holds promise for their directed differentiation into ameloblasts, which are usually lost after tooth eruption. Ameloblast differentiation is regulated by multiple signaling molecules, including bone morphogenetic proteins (BMPs). Epiprofin (Epfn), a transcription factor, is expressed in the dental epithelium, and epithelial Epfn overexpression results in ectopic ameloblast differentiation and enamel formation in mouse incisor, a striking phenotype resembling that of mice with deletion of follistatin (a BMP inhibitor). However, it remains unknown whether and how Epfn transcriptional activation promotes ameloblast induction from mouse iPSCs. Here, we generated doxycycline-inducible Epfn-expressing mouse iPSCs (Epfn-iPSCs). Ameloblasts, which are characterized by positive staining for keratin 14 and amelogenin and alizarin red S staining, were successfully derived from Epfn-iPSCs based on a stage-specific induction protocol, which involved the induction of the surface ectoderm, dental epithelial cells, and ameloblasts at stages 1, 2, and 3, respectively. Epfn activation by doxycycline at stages 2 and/or 3 decreased cell proliferation and promoted ameloblast differentiation, along with the upregulation of p-Smad1/5/8, a key regulator of the BMP-Smad signaling pathway. Gene analysis of the BMP-Smad signaling pathway-associated molecules revealed that Epfn activation decreased follistatin expression at stage 2, but increased BMP2/4/7 expression at stage 3. Perturbations in the ameloblast differentiation process were observed when the BMP-Smad signaling pathway was inhibited by a BMP receptor inhibitor (LDN-193189). Simultaneous LDN-193189 treatment and Epfn activation largely reversed the perturbations in ameloblast induction, with partial recovery of p-Smad1/5/8 expression, suggesting that Epfn activation promotes ameloblast induction from mouse iPSCs partially by upregulating BMP-Smad activity. These results reveal the potential regulatory networks between Epfn and the BMP-Smad pathway and suggest that Epfn is a promising target for inducing the differentiation of ameloblasts, which can be used in enamel and tooth regeneration.
Computer-Aided Design of α-L-Rhamnosidase to Increase the Synthesis Efficiency of Icariside I
Authors: Huang Jia-Jun , Hu Hao-Xuan , Lu Yu-Jing , Bao Ya-Dan , Zhou Jin-Lin , Huang Mingtao
Published: June 2022

Icariside I, the glycosylation product of icaritin, is a novel effective anti-cancer agent with immunological anti-tumor activity. However, very limited natural icariside I content hinders its direct extraction from plants. Therefore, we employed a computer-aided protein design strategy to improve the catalytic efficiency and substrate specificity of the α-L-rhamnosidase from Thermotoga petrophila DSM 13995, to provide a highly-efficient preparation method. Several beneficial mutants were obtained by expanding the active cavity. The catalytic efficiencies of all mutants were improved 16–200-fold compared with the wild-type TpeRha. The double-point mutant DH was the best mutant and showed the highest catalytic efficiency (kcat/KM: 193.52 s−1 M−1) against icariin, which was a 209.76-fold increase compared with the wild-type TpeRha. Besides, the single-point mutant H570A showed higher substrate specificity than that of the wild-type TpeRha in hydrolysis of different substrates. This study provides enzyme design strategies and principles for the hydrolysis of rhamnosyl natural products.
The C-Terminal Domain of Y-Box Binding Protein 1 Exhibits Structure-Specific Binding to Poly(ADP-Ribose), Which Regulates PARP1 Activity
Authors: Naumenko Konstantin N. , Sukhanova Mariya V. , Hamon Loic , Kurgina Tatyana A. , Anarbaev Rashid O. , Mangerich Aswin , Pastré David , Lavrik Olga I.
Published: June 2022

Y-box-binding protein 1 (YB-1) is a multifunctional protein involved in the regulation of gene expression. Recent studies showed that in addition to its role in the RNA and DNA metabolism, YB-1 is involved in the regulation of PARP1 activity, which catalyzes poly(ADP-ribose) [PAR] synthesis under genotoxic stress through auto-poly(ADP-ribosyl)ation or protein trans-poly(ADP-ribosyl)ation. Nonetheless, the exact mechanism by which YB-1 regulates PAR synthesis remains to be determined. YB-1 contains a disordered Ala/Pro-rich N-terminal domain, a cold shock domain, and an intrinsically disordered C-terminal domain (CTD) carrying four clusters of positively charged amino acid residues. Here, we examined the functional role of the disordered CTD of YB-1 in PAR binding and in the regulation of PARP1-driven PAR synthesis in vitro. We demonstrated that the rate of PARP1-dependent synthesis of PAR is higher in the presence of YB-1 and is tightly controlled by the interaction between YB-1 CTD and PAR. Moreover, YB-1 acts as an effective cofactor in the PAR synthesis catalyzed by the PARP1 point mutants that generate various PAR polymeric structures, namely, short hypo- or hyperbranched polymers. We showed that either a decrease in chain length or an increase in branching frequency of PAR affect its binding affinity for YB-1 and YB-1–mediated stimulation of PARP1 enzymatic activity. These results provide important insight into the mechanism underlying the regulation of PARP1 activity by PAR-binding proteins containing disordered regions with clusters of positively charged amino acid residues, suggesting that YB-1 CTD-like domains may be considered PAR “readers” just as other known PAR-binding modules.
The Critical Role of Ferroptosis in Hepatocellular Carcinoma
Authors: Pan Fan , Lin Xinrong , Hao Liping , Wang Ting , Song Haizhu , Wang Rui
Published: June 2022

Liver cancer is the sixth most frequently diagnosed cancer and the third dominant cause of cancer death worldwide. Ferroptosis is characterized as an iron-dependent form of regulated cell death, with accumulation of lipid peroxides to lethal amounts. Evidences have showed that ferroptosis is closely associated with HCC, but the mechanisms are still poorly understood. In this review, we mainly summarize the roles of several typical molecules as well as radiotherapy in regulating the ferroptosis process in HCC. Chances are that this review may help address specific issues in the treatment of HCC.
Won’t You be My Neighbor: How Epithelial Cells Connect Together to Build Global Tissue Polarity
Authors: Cote Lauren E. , Feldman Jessica L.
Published: June 2022

Epithelial tissues form continuous barriers to protect against external environments. Within these tissues, epithelial cells build environment-facing apical membranes, junction complexes that anchor neighbors together, and basolateral surfaces that face other cells. Critically, to form a continuous apical barrier, neighboring epithelial cells must align their apico-basolateral axes to create global polarity along the entire tissue. Here, we will review mechanisms of global tissue-level polarity establishment, with a focus on how neighboring epithelial cells of different origins align their apical surfaces. Epithelial cells with different developmental origins and/or that polarize at different times and places must align their respective apico-basolateral axes. Connecting different epithelial tissues into continuous sheets or tubes, termed epithelial fusion, has been most extensively studied in cases where neighboring cells initially dock at an apical-to-apical interface. However, epithelial cells can also meet basal-to-basal, posing several challenges for apical continuity. Pre-existing basement membrane between the tissues must be remodeled and/or removed, the cells involved in docking are specialized, and new cell-cell adhesions are formed. Each of these challenges can involve changes to apico-basolateral polarity of epithelial cells. This minireview highlights several in vivo examples of basal docking and how apico-basolateral polarity changes during epithelial fusion. Understanding the specific molecular mechanisms of basal docking is an area ripe for further exploration that will shed light on complex morphogenetic events that sculpt developing organisms and on the cellular mechanisms that can go awry during diseases involving the formation of cysts, fistulas, atresias, and metastases.