bluuebunny/crossref_metadata_2025 huggingface dataset:
The oncogenic driving force of CD30 signaling‐induced chromosomal instability in adult T‐cell leukemia/lymphoma
Authors: Nakashima Makoto , Utsunomiya Atae , Watanabe Toshiki , Horie Ryouichi , Uchimaru Kaoru
Published: December 2022

Adult T‐cell leukemia/lymphoma (ATL) develops via stepwise accumulation of gene mutations and chromosome aberrations. However, the molecular mechanisms underlying this tumorigenic process are poorly understood. We previously reported the presence of a biological link between the expression of CD30, which serves as a marker for ATL progression, and the actively proliferating fraction of human T‐cell leukemia virus type 1 (HTLV‐1)‐infected cells that display polylobulation. Here, we demonstrated that CD30 signaling induced chromosomal instability with clonal expansion through DNA double‐strand breaks (DSBs) via an increase of intracellular reactive oxygen species. CD30+ATL cells were composed of subclones with additional genomic aberrations compared with CD30−ATL cells in ATL patients. Furthermore, we found an accumulation of copy number loss of DSB repair‐related genes as the disease progressed. Taken together, CD30 expression on ATL cells appears to be correlated with genomic instability, suggesting that CD30 signaling is one of the oncogenic factors of ATL progression with clonal evolution. This study provides new insight into the biological roles of CD30 signaling and could improve our understanding of tumorigenic processes of HTLV‐1‐infected cells.
Prostaglandins differentially modulate mucosal‐associated invariant T‐cell activation and function according to stimulus
Authors: Mehta Hema , Tasin Irene , Hackstein Carl Philipp , Willberg Christian , Klenerman Paul
Published: December 2022

Mucosal‐associated invariant T (MAIT) cells are an innate‐like T‐cell type conserved in many mammals and especially abundant in humans. Their semi‐invariant T‐cell receptor (TCR) recognizes the major histocompatibility complex–like molecule MR1 presenting riboflavin intermediates associated with microbial metabolism. Full MAIT cell triggering requires costimulation via cytokines, and the cells can also be effectively triggered in a TCR‐independent manner by cytokines [e.g. interleukin (IL)‐12 and IL‐18 in combination]. Thus, triggering of MAIT cells is highly sensitive to local soluble mediators. Suppression of MAIT cell activation has not been well explored and could be very relevant to their roles in infection, inflammation and cancer. Prostaglandins (PG) are major local mediators of these microenvironments which can have regulatory roles for T cells. Here, we explored whether prostaglandins suppressed MAIT cell activation in response to TCR‐dependent and TCR‐independent signals. We found that protaglandin E2 (PGE2) and to a lesser extent protaglandin D2 (PGD2), but not leukotrienes, suppressed MAIT cell responses to Escherichia coli or TCR triggers. However, there was no impact on cytokine‐induced triggering. The inhibition was blocked by targeting the signaling mediated via PG receptor 2 (PTGER2) and 4 (PTGER4) receptors in combination. These data indicate that prostaglandins can potentially modulate local MAIT cell functions in vivo and indicate distinct regulation of the TCR‐dependent and TCR‐independent pathways of MAIT cell activation.
Some Metabolic Characteristics of Dairy Cows with Different Post Partum Ovarian Function
Authors: Huszenicza G. , Haraszti J. , Molnár L. , Solti L. , Fekete S. , Ekés K. , Yaro A. C.
Published: December 2022

The metabolic characteristics of cows with different post partum ovarian functions were investigated in 66 third‐fifth calving animals. For monitoring the metabolic status blood samples were taken in 1st, 3rd, 5th and 8 —10th post partum week. The glutamatc‐oxalacetate transaminase (GOT) activity, blood glucose level as well as the albumin, acetoacetic acid + acetone (ketone), non‐esterified fatty acid (NEFA), total cholesterol (TCH) and total carotene values in serum/plasma were determined. Milk samples were collected twice a week for 80—90 days after calving for progesterone analysis. In the same period rectal palpation was carried out every 7—14 days.

The cows with delayed onset of cyclicity, secondary acyclicity or irregular cyclicity showed considerably higher ketone and NEFA and obviously lower TCH and carotene levels than their mates with normal ovarian functions. The duration rather than the momentary degree of energy imbalance could influence the occurrence of these ovarian disorders. In case of cystic ovaries only slight metabolic differences were observed.
Local and General Effects of Salmonella typhimuHum Endotoxin in Calves
Authors: Luthman J. , Kindahl H. , Jacobsson S. O. , Thunberg L.
Published: December 2022

Endotoxin from Salmonella typhimurium was injected intravenously and into subcutaneously implanted tissue cages in calves. Intravenous injection of the doses 2μg/kg and 0.25μg/kg was followed by severe clinical signs, but the pyrogenic response was irregular. There was a dose‐related increase in the plasma level of IS‐ketodihydro‐PGF2α the main metabolite of PGF2α. The number of blood leukocytes decreased significantly immediately after the injection, but after 24 hours there was an increase far above the preinjection number. The serum levels of iron, zinc and calcium decreased significantly after the injection. The responses were similar to both doses of endotoxin.

The clinical counterparts to tissue cages are abscesses. It was concluded that endotoxin was released very slowly after injection into the cage as there were no changes in the serum concentrations of trace elements or in 15‐ketodihydro‐PGF2α Injection into the cage was followed by a dose‐ dependent increased of PGE2 in tissue cage fluid, while there were no changes in the concentration of trace elements. The leukocyte response was variable and it is therefore probable that PGE2 was produced entirely by the tissue within the cage. The results show that tissue cages may be a suitable model for the study of local inflammatory reactions.
Long‐term determinants of valuation effects
Authors: Kim Soyoung , Min Kyunghee
Published: December 2022

The progression of financial globalization increases the importance of valuation changes of foreign assets and liabilities, similar to that of current account in explaining the recent net foreign asset position of countries around the world. This study analyzes the long‐term determinants of valuation effects by using panel regression with 10‐year data span of 188 countries. The main findings are as follows. First, the size of foreign assets and relative portion of risky assets are positively associated with valuation effects, which suggests that general principles for long‐term individual investors also hold for an entire country. Second, current account is negatively associated with valuation effects, which suggests that these two mechanisms stabilize each other in overall international adjustment process. Third, exchange rate changes are often positively associated with valuation effects, which at times depend on foreign asset and liability positions. Fourth, per capita GDP are negatively associated with valuation effects. Fifth, current account is mainly associated with valuation effects due to asset price changes, but exchange rate changes and foreign asset and liability positions are mainly associated with valuation effects due to exchange rate changes. The relative proportion of risky assets is associated with both types of valuation effects.
The Inclusion of a Complementary Running Progression Program in the Rehabilitation of Acute Hamstring Injuries: A Critically Appraised Topic
Authors: Sandrey Michelle A.
Published: December 2022

Introduction/Clinical Scenario: As many hamstring injuries occur when the hamstrings are in a lengthened state during the deceleration phase of running when the muscle is eccentrically contracting to slow the body down this functional aspect needs to be addressed. Thus, a rehabilitation program with a focus on progressive targeted eccentric hamstring exercises by gradually placing and exposing the muscle to eccentric force in a lengthened state supplemented with progressive running drills should be evaluated. Focused Clinical Question: Does the inclusion of a complementary running progression program for the rehabilitation of an acute hamstring injury reduce the time to safe return to sport with less hamstring reinjury occurrence for an athletic population? Summary of Key Findings: Three studies assessed the inclusion of a progressive running program with several types of running progression parameters addressed. Progressive running drills will load the hamstring in a functional manner, with a gradual increase in velocity of movement and lengthening of the muscle. Clinical Bottom Line: It appears that a complementary progressive running program within an acute hamstring rehabilitation program should be included as it caused no further harm and does not tend to increase hamstring reinjury occurrence. Strength of Recommendation: There is grade B evidence to include a complementary running progression program within an acute hamstring rehabilitation program.
Complete Genome Sequences of a Stress-Resistant Outbreak-Associated Shiga Toxin-Producing Escherichia coli O157:H7 Strain and a Variant with Enhanced Congo Red-Binding Capability
Authors: Chen Chin-Yi , Kanrar Siddhartha , Paoli George C.
Published: December 2022

The genome sequences of
Escherichia coli
O157:H7 strain 380-94, which was isolated from a 1994 dry-cured salami outbreak, and a stronger Congo red-binding variant, RV06, were determined using long-read sequencing technology and
de novo
assembly. Both strains possessed one chromosome and one plasmid. Strain RV06 possessed a 4,769-bp deletion in the
rcs
region.
An IFDM analysis of low Reynolds number flow generated in a complex wavy curved passage formed by artificial beating cilia
Authors: Asghar Zeeshan , Khan Muhammad Waris Saeed , Shatanawi Wasfi , Gondal Muhammad Asif , Ghaffari Abuzar
Published: December 2022

Mother nature utilizes an assembly of beating cilia to transport liquid in various circumstances. The arrays of these hair-like cellular appendages also aid in propelling microorganisms like spermatozoa and paramecium. In our implicit finite difference analysis, we present a pumping performance of a curved channel comprising mucus flow induced via active cilium. The non-Newtonian mucus is modelled as Carreau fluid model. The undulating cilia attached with curved walls are assumed to be complex wavy. The tips of these cilia form a complex wavy peristaltic curved passage with porous medium effects. Well-known continuity and momentum equations (in curvilinear coordinates) are utilized to model the flow problem. Cilia-driven flow is creeping which is based on low Reynolds number assumption. Moreover, long wavelength assumption is also employed in this analysis. The reduced fourth-order BVP is solved via implicit finite difference method (IFDM). The computed results are plotted by using MATLAB (2021a). The mucus velocity is plotted at three different cross-sections and flow rates. Moreover, velocity of mucus, pressure gradient, pressure rise, and level curves are also expounded for various rheological, porous and cilia-based parameters. A special case of straight passage is also presented in the graphical result section.
Analysis of Landau level contribution to pseudo chiral magnetic effect in Weyl–Dirac matter
Authors: Chauhan Bhupendra C. S. , Joshi Pawan Kumar
Published: December 2022

This study is motivated by the recent observed realization of Pseudo Chiral Magnetic Effect (PCME) into the continuum limit of the low-energy tight binding description of graphene. We here proposed the quantum description of PCME by investigating the Landau level structure of the system. The different physical quantities like current, chiral currents, number densities and chiral condensate are discussed in this context with this Landau level description of the system. Further, the effect of different physical conditions to the system is studied by analyzing the behavior of Landau levels under these conditions. This provides a microscopic understanding of the phenomenon. It has been shown that largest contribution to the PCME currents and number densities comes from the spin polarized lowest Landau level which corresponds to the system characteristics at low-temperature and high magnetic field. However, the contribution to the PCME current from the higher Landau levels is just opposite to that from the lowest Landau level. We have further established general expressions for all these physical quantities regarding to any higher-order Landau level.
Qualia, Consciousness and Artificial Intelligence
Authors: Haikonen Pentti O.
Published: December 2022

It is noted that there are many different definitions of and views about qualia, and this makes qualia into a vague concept without much theoretical and constructive value. Here, qualia are redefined in a more general way. It is argued that the redefined qualia will be essential to the mind–body problem, the problem of consciousness and also to the symbol grounding problem, which is inherent in physical symbol systems. Then, it is argued that the redefined qualia are necessary for Artificial Intelligence systems for the operation with meanings. Finally, it is proposed that robots with qualia may be conscious.
Predicting Risk Factors of Acute Kidney Injury in the First 7 Days after Admission: Analysis of a Group of Critically Ill Patients
Authors: Wen Kexin , Huang Yongqing , Guo Qi , Wu Tao , Liu Juanzhang , Zheng Yuping , Zhou Shuxian , Geng Dengfeng
Published: December 2022

Background. Acute kidney injury (AKI) is a common complication in critically ill patients. Some predictive models have been reported, but the conclusions are controversial. The aim of this study was the formation of nomograms to predict risk factors for AKI in critically ill patients within the first 7 days after admission to the intensive care unit (ICU). Methods. Data were extracted from the Medical Information Mart for Intensive Care- (MIMIC-) III database. The random forest method was used to fill in the missing values, and least absolute shrinkage and selection operator (Lasso) regression analysis was performed to screen for possible risk factors. Results. A total of 561 patients were enrolled. Complication with AKI is significantly associated with a longer length of stay (LOS). For all patients, the predictors contained in the prediction nomogram included hypertension, coronary artery disease (CAD), cardiopulmonary bypass (CPB), coronary artery bypass grafting (CABG), Simplified Acute Physiology Score II (SAPS II), central venous pressure (CVP) measured for the first time after admission, and maximum and minimum mean artery pressure (MAP). The model showed good discrimination (

C
−
index
=
0.818

, 95% CI: 0.779-0.857). In the subgroup of patients with well-controlled blood glucose levels, the significant predictors included hypertension, CABG, CPB, SAPS II, and maximum and minimum MAP. Good discrimination was also present before (

C
−
index
=
0.785

, 95% CI: 0.736–0.834) and after adjustment (adjusted

C
−
index
=
0.770

). Conclusion. Hypertension, CAD, CPB, CABG, SAPS II, CVP measured for the first time after admission, and maximum and minimum MAP were independent risk factors for AKI in critically ill patients.
Sustained Control of Serpiginous Choroiditis with the Fluocinolone Acetonide 0.18 mg Intravitreal Implant
Authors: Siddiqui Yousuf , Adams Olufemi E. , Simmons Michael A. , Yamanuha Justin , Koozekanani Dara D.
Published: December 2022

Purpose. To describe an alternative treatment for a patient with serpiginous choroiditis (SC) who was not tolerant to systemic therapies. Methods. Case report of a patient with serpiginous choroiditis with their clinical course followed with ophthalmic examinations and multimodal imaging overtime. Patients and Results. A 57-year-old female with serpiginous choroiditis was treated for seven years with numerous therapies including systemic steroids, immunosuppressive agents, and repeated dexamethasone intravitreal implants. The patient was intolerant of systemic therapies and would flare if dexamethasone injections were performed less frequently than every 8 weeks, making a viable long-term treatment plan problematic. Following one injection of the fluocinolone acetonide 0.18 mg intravitreal implant, she has experienced sustained control for 20 months. Discussion and Conclusions. Real-world treatment of SC is complex as long-term control is necessary, and associated side effects of the therapies provided may limit sustained use. The fluocinolone acetonide implant lasts 36 months and may be an alternative long-term management option, especially in the setting of systemic medication intolerance for some patients with SC.
Validity of Adult Psychopathology Model Using Psychiatric Patient Sample from a Developing Country: Confirmatory Factor Analysis
Authors: Alareqe Naser Abdulhafeeth , Hassan Siti Aishah , Kamarudin Engku Mardiah Engku , Aljaberi Musheer A. , Nordin Mohamad Sahari , Ashureay Nadeem Mohamed , Mohammed Lubna Ali
Published: December 2022

Objectives. This study is aimed at testing and validating the two-factor measurement model of the Millon Clinical Multiaxial Inventory (MCMI). Specifically, this paper reported construct validity, particularly focusing on convergent and discriminant validities of the internalizing-externalizing MCMI model of adult psychopathology using a psychiatric sample from a developing country, the Republic of Yemen. Methods. MCMI was distributed among 232 outpatients from the Hospital of Taiz City and two private psychiatry clinics in Yemen; data were collected using structured interviews over four months. We used exploratory factor analysis (EFA) and confirmatory factor analysis (CFA) to explore and confirm the latent structure MCMI and verify the evidence of convergent and discriminant validity. Results. The CFA results indicated that MCMI was a good fit for the internalizing-externalizing two-factor model of adult psychopathology, comparative fit index

CFI

=
0.95

, and

RMSEA
=
0.07

. The results of the CFA provide evidence of convergent and discriminant validity characterized by MCMI with the internalizing-externalizing model. Conclusion. The adult psychopathology of internalizing-externalizing is a valid measurement model of MCMI with ten personality disorders and eight clinical syndromes.
Stromal Reprogramming through Dual PDGFRα/β Blockade Boosts the Efficacy of Anti–PD-1 Immunotherapy in Fibrotic Tumors
Authors: Akiyama Takahiko , Yasuda Tadahito , Uchihara Tomoyuki , Yasuda-Yoshihara Noriko , Tan Benjy J.Y. , Yonemura Atsuko , Semba Takashi , Yamasaki Juntaro , Komohara Yoshihiro , Ohnishi Koji , Wei Feng , Fu Lingfeng , Zhang Jun , Kitamura Fumimasa , Yamashita Kohei , Eto Kojiro , Iwagami Shiro , Tsukamoto Hirotake , Umemoto Terumasa , Masuda Mari , Nagano Osamu , Satou Yorifumi , Saya Hideyuki , Tan Patrick , Baba Hideo , Ishimoto Takatsugu
Published: December 2022

Excess stroma and cancer-associated fibroblasts (CAF) enhance cancer progression and facilitate immune evasion. Insights into the mechanisms by which the stroma manipulates the immune microenvironment could help improve cancer treatment. Here, we aimed to elucidate potential approaches for stromal reprogramming and improved cancer immunotherapy. Platelet-derived growth factor C (PDGFC) and D expression were significantly associated with a poor prognosis in patients with gastric cancer, and PDGF receptor beta (PDGFRβ) was predominantly expressed in diffuse-type gastric cancer stroma. CAFs stimulated with PDGFs exhibited markedly increased expression of CXCL1, CXCL3, CXCL5, and CXCL8, which are involved in polymorphonuclear myeloid-derived suppressor cell (PMN-MDSC) recruitment. Fibrotic gastric cancer xenograft tumors exhibited increased PMN-MDSC accumulation and decreased lymphocyte infiltration, as well as resistance to anti–PD-1. Single-cell RNA sequencing and spatial transcriptomics revealed that PDGFRα/β blockade reversed the immunosuppressive microenvironment through stromal modification. Finally, combining PDGFRα/β blockade and anti–PD-1 treatment synergistically suppressed the growth of fibrotic tumors. These findings highlight the impact of stromal reprogramming on immune reactivation and the potential for combined immunotherapy for patients with fibrotic cancer.

Significance:

Stromal targeting with PDGFRα/β dual blockade reverses the immunosuppressive microenvironment and enhances the efficacy of immune checkpoint inhibitors in fibrotic cancer.

See related commentary by Tauriello, p. 655
A psicanálise, o pensamento científico e o real: uma nota propedêutica ao debate sobre a experiência educativa
Authors: Lajonquière Leandro de
Published: December 2022

O desdobramento dos estudos psicanalíticos em educação e formação é parasitado de tempos em tempos por consignas supostamente psicanalíticas. Nos dias de hoje constata-se a proliferação de referências ao termo real bastantes imprecisas com relação ao uso que Lacan fez do mesmo. O artigo visa esclarecer de forma propedêutica o uso do termo real no pensamento lacaniano no contexto preciso de uma operação singular de subversão do pensamento metafísico. O autor sustenta que o real lacaniano se inscreve no “retorno a Freud” de forma tal que ele constitui tanto a precipitação de uma diferença quanto o estabelecimento de uma continuidade com o pensamento freudiano. O texto objetiva assim o desafio de fazer avançar os estudos no campo, em particular a pergunta do que se transmite na experiência educativa, sobre outras bases que não sejam a repetição ecolálica de certas ideias pouco claras e precisas dos clássicos do pensamento psicanalítico.
A motivação para a prática desportiva em escolares: implicações entre ensino diurno e noturno
Authors: Oliveira Vinicius Machado de , Brasil Marcos Roberto , Mattes Verônica Volski , Menegaldo Pedro Henrique Iglesiaz , Badaró Luiz Fernando , Reis Rafael Augusto Marques dos , Souza Neidiana Braga da Silva , Ribas Schelyne
Published: December 2022

Este estudo teve como objetivo investigar e comparar a motivação esportiva entre escolares do ensino diurno e noturno. Participaram da pesquisa 222 escolares, de ambos os sexos, do ensino médio de duas escolas públicas da cidade de Guarapuava-PR. Para a verificação da motivação esportiva, foi utilizado o questionário Sport Motivation Scale (SMS). Após a coleta, os dados foram tabulados e submetidos a análises estatísticas inferenciais, bem como a análise teórica por meio da discussão com a literatura especializada. Posteriormente as análises, os resultados demonstraram que escolares do ensino noturno apresentam níveis motivacionais mais satisfatórios quando comparados com discentes do ensino diurno, indicando, portanto, que o estudo noturno não interfere negativamente na prática esportiva.
Antropometria e aptidão física em atletas de handebol masculino regional por posição de jogo
Authors: Toescher Guilherme Köpp , Marcon Leandro Galletti , Marques Leonardo Ribeiro , Silva Fernando Andrade da , Mainenti Míriam Raquel Meira
Published: December 2022

O conhecimento do perfil antropométrico e de aptidão física das diferentes posições de jogo no handebol pode auxiliar na seleção e treinamento específico dos atletas, mas a literatura nacional carece dessas informações. O objetivo deste estudo foi verificar diferenças antropométricas e de aptidão física em atletas de handebol masculino de nível regional de diferentes posições. Dezesseis atletas (26,63±2,63 anos) das posições de armador, ponta e pivô foram avaliados em: estatura, envergadura, massa corporal total (MCT) e índice de massa corporal; perímetros dos membros, cintura e quadril; dimensões da mão; composição corporal absoluta (kg) e relativa (%); testes de sentar e alcançar, preensão manual, arremesso de medicine ball, agilidade, Counter Movement Jump e Running-based Anaerobic Sprint Test (RAST). Foram organizados dois grupos: pontas e armadores+pivôs, devido a semelhanças nas exigências físicas. Para análise estatística foi utilizado o teste-t de Student para amostras independentes (p<0,05), expressando os dados com média e desvio padrão. Houve diferenças estatisticamente significativas, com resultados inferiores dos pontas, na MCT (79,82±12,38.vs.91,84±7,79kg), perímetro do antebraço (28,05±1,90.vs.30,05±1,20cm) e quadril (98,00±6,80.vs.104,81±4,27cm), comprimento da mão (18,83±0,59.vs.20,04±1,02cm), largura da mão (22,08±1,58.vs.24,34±1,30cm), massa livre de gordura absoluta (68,28±6,94.vs.76,68±6,45kg) e potência média (376,92±34,54.vs.474,94±71,72w) do RAST. Assim sendo, os pontas se destacam pelas menores dimensões corporais; armadores e pivôs se sobressaem na resistência de potência. Tais diferenças se devem, provavelmente, às valências físicas necessárias às posições, considerando que os pontas precisam de agilidade e mobilidade, ao passo que armadores e pivôs precisam travar mais contatos físicos e realizar ações que demandam força e potência.
Influência da hereditariedade para hipertensão arterial na hipotensão pós-exercício
Authors: Mendonça William Ferreira , Pereira Natália Portela , Mira Pedro Augusto de Carvalho , Silva Lilian Pinto da , Henrique Diane Michela Nery , Trevizan Patrícia Fernandes , Toschi-Dias Edgar , Martinez Daniel Godoy , Laterza Mateus Camaroti
Published: December 2022

Verificar o comportamento cardiovascular de homens normotensos com histórico familiar positivo para hipertensão arterial proveniente da mãe e de homens normotensos com histórico familiar proveniente do pai após uma sessão de exercício aeróbio. Foram selecionados 35 homens adultos divididos nos grupos: HF+mãe (somente mãe com hipertensão arterial, n=14) e HF+pai (somente pai com hipertensão arterial, n=21). Os participantes foram submetidos ao exercício aeróbio, em cicloergômetro (Kikos®), por 50 minutos, em intensidade de 50 a 70% da frequência cardíaca de reserva (sessão exercício) e a uma sessão controle. As variáveis pressão arterial média (FinometerPro®) e fluxo sanguíneo do antebraço (Pletismografia de Oclusão Venosa-Hokanson®) foram registradas continuamente durante 10 minutos pré e 30 minutos pós cada sessão. A resistência vascular do antebraço foi calculada pela divisão da pressão arterial média pelo fluxo sanguíneo do antebraço. Foi considerado p≤0,05 como diferença significativa. No grupo HF+mãe a pressão arterial média e a resistência vascular do antebraço não modificaram significativamente no momento pós em relação ao momento pré-exercício. Diferentemente, no grupo HF+pai a pressão arterial média e resistência vascular do antebraço reduziram significativamente na recuperação do exercício. Na sessão controle essas variáveis aumentaram significativamente no pós em relação ao pré, em ambos os grupos. O exercício físico não provocou modificações no sistema cardiovascular de homens normotensos, com histórico familiar positivo para hipertensão proveniente da mãe. Enquanto aqueles com histórico familiar positivo para hipertensão proveniente do pai apresentaram hipotensão pós-exercício, comportamento parcialmente justificado pela diminuição da resistência vascular do antebraço.
Desenvolvimento da natação em uma política de esporte municipal: estudo de caso na cidade de Limeira - SP
Authors: Bueno Bruna Lindman , Mazzei Leandro Carlos , Scaglia Alcides José
Published: December 2022

O estudo objetivou apresentar as condições que envolvem a promoção da natação no município de Limeira/SP, considerando as políticas públicas implementadas, as instalações disponíveis para a prática da modalidade, o apoio de organizações esportivas e ainda os programas oferecidos. Trata-se de um estudo descritivo, utilizando da pesquisa documental quanto seus meios. Os resultados apontam que o município analisado apresenta potencial para o desenvolvimento da natação, visto que dispõe de um elevado número de piscinas públicas e possui apoio de organizações esportivas para a oferta e execução de projetos para a prática da modalidade. Aliando tais potencialidades a um maior conhecimento do público-alvo, certamente a promoção da natação no município apresentará bons resultados.
As artes marciais no discurso de professores de Educação Física Escolar: “nem sempre o currículo dá certo”
Authors: Oliveira Lázaro Rocha , Guirado Marlene , Correia Walter Roberto
Published: December 2022

O Currículo do Estado de São Paulo impele professores de Educação Física Escolar (EFE) a abordarem a temática das artes marciais (AM) em suas aulas. Este estudo teve por objetivo delinear o lugar que as AM ocupam no discurso de professores de EFE da cidade de São Paulo. Foram entrevistados professores que trabalhavam na região da cidade cujo regime de implantação do novo Currículo estava mais consolidado. A partir de uma análise institucional do discurso dos entrevistados, verificou-se que há um desconhecimento da possibilidade de aproximação entre as AM e a EFE. A temática das AM ocupa no discurso dos entrevistados um lugar privilegiado no circuito da teoria, e isso gera insatisfação. O potencial do trabalho com as AM é visto como uma possibilidade apenas para além dos muros da escola. O Currículo que promove o resgate das AM na EFE ascende também como um currículo deslocado da realidade escolar.
Comparação entre o polimorfismo do gene Apoe na composição corporal, potência muscular e Total Genotype Score (TGS)
Authors: Freitas Nei Adão Ribeiro de , Dall Agnol Simone Mader , Magni Cristiana , Silva Paulo Roberto da , Santos Cesar Augusto de Souza , Mascarenhas Luis Paulo Gomes
Published: December 2022

Descrever o perfil de saúde dos grupos estudados, verificar a frequência dos alelos e dos genótipos do gene Apolipoproteína E (ApoE) e comparar os polimorfismos do gene ApoE com composição corporal, potência de membros inferiores (MMIIs) e total genotype score (TGS), a amostra foi composta por 81 indivíduos. O ácido desoxirribonucleico (ADN) foi obtido a partir de amostras do esfregaço da mucosa oral. A composição corporal foi avaliada pela balança de bioimpedância OMRON e a potência de MMIIs foi mensurada pelo tapete de contato da Hidrofit, com os testes Squat jump (SJ) e Counter moviment jump (CMJ). O grupo 1 (ɛ2) foi composto por 65% acometidos por acidente vascular cerebral (AVC), a altura dos testes CMJ 6,08±3,8 e SJ 4,77±3,4. O grupo 2 (ɛ3) foi composto 17,1% de indivíduos acometidos por AVC, a altura do CMJ 10,3±5,4 e SJ 8,3±5,2. O grupo ɛ4 apresentou indivíduos com AVC 28,6%. Altura no CMJ 11,7±7,4 e SJ 9,8±7,3. O grupo Ɛ2/Ɛ4 apresentou altura no CMJ 5,71±4,9 e SJ 4,36±3,2. Os alelos ɛ3 e ɛ4 apresentaram diferença significativa em relação ao grupo ɛ2 nos testes CMJ e SJ. As médias dos alelos foram: ɛ3 (69,8%); ɛ2 (16,6%) e ɛ4 (13,6%). O genótipo Ɛ3/Ɛ3 foi o mais prevalente (50,6%).  A frequência alélica que prevaleceu na amostra deste estudo foi do alelo ɛ3 e 65 % dos portadores do alelo ɛ2 são acometidos por AVC. Os portadores do alelo ɛ3 e ɛ4 obtiveram diferença significativa na força muscular em comparação com o grupo ɛ2. O TGS se apresentou com 50, em 58% da amostra e em portadores do ɛ3.
Jiu Jitsu como instrumento de tratamento para crianças com Transtorno do Espectro Autista
Authors: Lima Leonardo Sprovieri , Amaral Maíra Ferreira do , Fontes Victor Augusto Meneguini , Couto Crislaine Rangel , Almohalha Lucieny , Santos Suziane Peixoto
Published: December 2022

O objetivo deste estudo foi verificar os efeitos de um programa de jiu jitsu no desempenho motor e nas habilidades funcionais (autocuidado e função social) de crianças com TEA. A amostra constituiu de seis crianças, três do grupo controle e três do grupo experimental com idades entre 6 e 12 anos submetidas à prática do jiu jitsu. A intervenção teve duração de um ano e três meses (80 sessões). Os instrumentos utilizados foram o Test of Gross Motor Development-2, e o Pediatric Evalution of Disability Inventory. Os resultados apontam melhoras significativas do grupo experimental após a intervenção no desempenho manipulativo, no autocuidado, na função social, e menor ajuda dos pais para a realização das tarefas. É possível concluir que o jiu jitsu representa um instrumento de tratamento para o TEA contribuindo para o planejamento das intervenções e auxiliando os treinadores e os profissionais da saúde.
O Programa de Educação Tutorial e a Educação Física: alunos egressos e as relações com o saber
Authors: Freitas Gama Jean Carlos , Schneider Omar
Published: December 2022

Objetiva analisar os sentidos atribuídos, por alunos egressos do grupo PET do curso de Educação Física de uma universidade, às práticas e experiências vivenciadas, bem como suas implicações para a formação acadêmica, profissional e social. Apropria-se da teoria da Relação com o Saber como suporte teórico e de análise, também assume a racionalidade da história cultural. Trata-se de uma pesquisa qualitativa do tipo descritiva-interpretativa. Como fontes, utiliza documentos e registros localizados nos arquivos do PET EF além de entrevistas filmadas, realizadas com 28 bolsistas que fizeram parte do programa entre 1994 e 2018. Possui um roteiro semiestruturado com 11 questões abertas para produção dos dados. As análises demonstram que o perfil de um aluno que busca o Programa é amplo e que a maioria enxerga nele a potencialização de suas experiências práticas e acadêmicas dentro do curso em que se insere. O PET passou por transformações significativas ao longo dos anos e, assim, a produção de sentidos sobre os saberes apropriados e as repercussões na formação dos entrevistados se mostrou com diferentes centralidades. Observamos que, no caso da Educação Física, o aperfeiçoamento para uma melhor formação acadêmica e a apropriação de conteúdos diversificados foram as principais contribuições do PET EF apontadas nas narrativas dos entrevistados. Além disso, a qualificação profissional para atuação no campo de trabalho e o relacionamento interpessoal no convívio em grupo também foram captados nas falas. Outros participantes ainda apontam que não houve contribuição significativa do programa em suas formações.
Habilidades motoras fundamentais na abordagem desenvolvimentista e nos programas de atividade física visando à saúde
Authors: Tani Go
Published: December 2022

O presente ensaio tem como objetivo discutir as coincidências, convergências e divergências entre a abordagem desenvolvimentista da Educação Física escolar (AD) e os programas de atividade física visando à saúde (PAFVS) no que se refere a trato com as habilidades motoras fundamentais (HMF). A coincidência está no fato de o desenvolvimento de HMF constituir-se um foco importante de intervenção em ambos. Na AD está atrelado a objetivos educacionais de formação do cidadão; no PAFVS aos objetivos de saúde do indivíduo, particularmente à prevenção de doenças crônico-degenerativas. A convergência está em enfatizar a relevância das HMF para o desenvolvimento ulterior e contínuo de habilidades motoras específicas. Sem uma base motora bem desenvolvida na infância relativamente a HMF, o envolvimento com a prática sistemática de habilidades motoras específicas na adolescência e na idade adulta fica prejudicado. Como consequência, a promoção e a manutenção de saúde ficam dificultadas. A divergência está no fato de o desenvolvimento de HMF se constituir, na AD, um objetivo a ser alcançado, enquanto que no PAFVS ele é um meio para a saúde. Para a AD, a aquisição de habilidades motoras, sejam elas fundamentais ou específicas, não se configura um meio para alcance de outros objetivos, por exemplo, a saúde. Isto não quer dizer que ela esteja dissociada dos objetivos de saúde, visto que, como consequência do processo de aquisição de habilidades motoras, os benefícios apontados e ressaltados pelo PAFVS podem também ser obtidos.
Sal no Machado
Authors: Bonavina Rafael
Published: December 2022

Resenha do livro Sal no machado, uma antologia de poemas de Ossip Mandelstam, traduzidos por Astier Basílio.
Roma eterna e Roma condenada: o mito de São Petersburgo em "O cavaleiro de bronze"
Authors: Zorattini Júlia
Published: December 2022

O presente artigo busca analisar o poema O cavaleiro de bronze (1833), da autoria de Aleksandr Púchkin, e sua contribuição na construção do mito fundador da cidade de São Petersburgo. Para tanto, faz-se uso dos conceitos ligados à semiologia do espaço e da cultura, desenvolvidos por Iúri Lotman e Vladimir Toporov.
Memória
Authors: Lachmann Renate
Published: December 2022

Este ensaio analisa como a categoria Memória percorre a produção teórica de Lotman. O pensador russo analisa uma nova teoria da memória, que ele desenvolve como parte essencial da cultura concebida como um sistema semiótico, conceito desenvolvido nas obras da escola Tártu-Moscou. Visando descrever as técnicas de autointerpretação e automodelagem (transformação, tradução, transcodificação) por meio do qual uma cultura tenta se estabilizar.
Limb Apraxias: The Influence of Higher Order Perceptual and Semantic Deficits in Motor Recovery After Stroke
Authors: Rounis Elisabeth , Binkofski Ferdinand
Published: December 2022

Stroke is a leading cause of disability worldwide. Limb apraxia is a group of higher order motor disorders associated with greater disability and dependence after stroke. Original neuropsychology studies distinguished separate brain pathways involved in perception and action, known as the dual stream hypothesis. This framework has allowed a better understanding of the deficits identified in Limb Apraxia. In this review, we propose a hierarchical organization of this disorder, in which a distinction can be made between several visuomotor pathways that lead to purposeful actions. Based on this, executive apraxias (such as limb kinetic apraxia) cause deficits in executing fine motor hand skills, and intermediate apraxias (such as optic ataxia and tactile apraxia) cause deficits in reaching to grasp and manipulating objects in space. These disorders usually affect the contralesional limb. A further set of disorders collectively known as limb apraxias include deficits in gesture imitation, pantomime, gesture recognition, and object use. These are due to deficits in integrating perceptual and semantic information to generate complex movements. Limb apraxias are usually caused by left-hemisphere lesions in right-handed stroke patients, affecting both limbs. An anterior- to posterior-axis of brain areas are disrupted depending on the increasing involvement of perceptual and semantic processes with each condition. Lower-level executive apraxias are linked to lesions in the frontal lobe and the basal ganglia, while intermediate apraxias are linked to lesions in dorso-dorsal subdivisions of the dorsal fronto-parietal networks. Limb apraxias can be caused by lesions in both dorsal and ventral subdivisions including the ventro-dorsal stream and a third visuomotor pathway, involved in body schema and social cognition. Rehabilitation of these disorders with behavioral therapies has aimed to either restore perceptuo-semantic deficits or compensate to overcome these deficits. Further studies are required to better stratify patients, using modern neurophysiology and neuroimaging techniques, to provide targeted and personalized therapies for these disorders in the future.
The Relationship Between Defense Expenditures and Economic Growth: Rolling-Window Causality Test
Authors: ZUHAL Mustafa
Published: December 2022

Defense expenditures have an essential place in the growth of countries. Defense expenditures and economic growth are frequently linked in the literature. The relationship between these variables may alter according to time and country-specific characteristics. This study examines the causality relationship between defense expenditures and economic growth with the rolling-window causality. For all panels, the study found bidirectional causality only in China and unidirectional causality in S. Korea and the UK. On the other hand, the rolling-window causality test detected bidirectional causality between the variables in all countries except the USA. Economic growth and defense expenditures have a unidirectional causality in the USA.
THE ROLE OF INFLATION TARGETING ON EXCHANGE RATE VOLATILITY: AN EVIDENCE FROM PROPENSITY SCORE MATCHING APPROACH
Authors: YÜKSEL Güntülü Özlem , BAYCAN İsmail Onur
Published: December 2022

This study examines the treatment effects of inflation targeting on exchange rate volatility across a large panel of 91 (36 inflation targeting) countries over the 1985-2019 period on annual basis. We apply propensity score matching methods to developed, developing, and high-income inflation targeting countries and non-inflation targeting countries. Our results reveal that, on average, adopting the inflation targeting policy exerts lower exchange rate volatility in all sample and developing economies. However, subgroups results demonstrate that inflation targeting regimes may lead to higher exchange rate volatility in developed and high-income economies. The outcome from different degrees of flexibility of exchange rates subgroups points out that the inflation targeting regime has significant and lower exchange rate volatility under free-floating regimes however this policy stance has no discernible effect on floating regimes. Additionally, adopted inflation targeting countries are affected by less damage on exchange rate volatility than those adopting exchange rate targeting regimes.
Reply: The Persistent Absence of Empirical Evidence for Free-Riding in Global Climate Politics
Authors: Aklin Michaël , Mildenberger Matto
Published: December 2022

Kennard and Schnakenberg (KS) raise three concerns regarding Aklin and Mildenberger (“Prisoners of the Wrong Dilemma: Why Distributive Conflict, Not Collective Action, Characterizes the Politics of Climate Change,” Global Environmental Politics 20 (4): 4–27). In this response, we delineate where we agree and where we disagree with KS. We then consider whether the model presented by KS changes our assessment that free-riding concerns are not currently the binding constraint on global climate politics. We conclude with a refined statement of our original claim.
Prevalence, Morphology, and Predictors of Intra-Stent Plaque Rupture in Patients with Acute Coronary Syndrome: An Optical Coherence Tomography Study
Authors: Yu Huai , Dai Jiannan , Fang Chao , Jiang Senqing , Mintz Gary S. , Yu Bo
Published: December 2022

Previous studies have shown that plaque rupture (PR) is the most important cause of acute coronary syndrome (ACS). However, the potential impact of intra-stent PR on stent failure manifesting as ACS and the optical coherence tomography (OCT) features of these lesions was still less clear. Therefore, we aimed to investigate the characteristics of OCT-defined in-stent PR and identify the potential risk factors for PR in ACS patients. All 213 ACS patients were stratified into two groups according to the occurrence of in-stent PR. The baseline characteristics of all patients were investigated. A multivariable logistic regression was performed to identify factors associated with the formation of PR. OCT findings showed that 80 patients had in-stent PR, and 133 patients were without PR. Patients who suffered in-stent PR had higher blood lipid levels ( P < .050) and longer duration of stent failure ( P = .001). Moreover, thrombolysis in myocardial infarction (TIMI) 0/1 flow was more prone to the formation of PR ( P = .010), and lesions in the PR group harbored more macrophages and cholesterol crystals ( P < .001 and P = .024). On multivariate analysis, presentation of myocardial infarction (MI) and OCT findings of lipidic neointima length showed a 3.6-fold ( P = .004) and 1.3-fold ( P < .001) higher risk for occurrence of in-stent PR. ACS patients who suffered in-stent PR had a longer duration of stent failure and more ISR occurring in non-culprit vessels. Given the distinguishing features between ACS patients with in-stent PR and non-PR, potential targeted therapy was warranted to improve the prognosis of patients with in-stent PR.
“When there's collective leadership, there's the power to make changes”: A realist evaluation of a collective leadership intervention (Co-Lead) in healthcare teams
Authors: De Brún A. , McAuliffe E.
Published: December 2022

There is accumulating evidence for collective approaches to leadership, where multiple individuals share leadership roles, but there remains a lack of theory-informed research on how collective leadership is fostered in practice. This study evaluated the impact of a collective leadership intervention, exploring what works for whom, how, and under what circumstances through a mixed-methods realist evaluation of four case studies. Eight context-mechanism-outcome configurations (theories) were extrapolated that elucidate the mechanisms triggered to drive outcomes in particular settings. This is the first study to apply a realist lens to understand collective leadership and articulate the generative mechanisms that enable/inhibit collective leadership in healthcare teams.
Prostate cancers in men under the age of 50: about a series in Togo, Sub-Saharan Africa
Authors: Darré Tchin , Djiwa Toukilnan , Kpatcha Tchilabalo Matchonna , Padja Essodina , Napo-Koura Gado , DARRE Tchin
Published: December 2022

Background

Prostate cancer is a public health problem and increasingly diagnosed in men under 50 years of age. This cancer occurs much more in subjects of advanced age, generally over sixty. The aim of the study was to describe the epidemiological, clinical and histopathological aspects of prostate cancer in men under the age of 50 in Togo.

Methods

It was a retrospective descriptive, cross-sectional study of histologically confirmed cases of prostate cancer in young adults at the Pathological Laboratory of Lomé over a period of 10 years (2011–2020).

Results

In total, 29 cases of prostate cancer in patients under 50 years of age. The proportion of prostate cancers in men under 50 was 0.7% of all prostate cancers, The average age of the patients was 45 years with extremes of 35 and 49 years. Twelve patients had a family history of prostate cancer, with a statistically significant relationship between the existence of a family history of prostate cancer and the age of onset of the cancer (p-value = 0.03). The dominant clinical information was prostatic hypertrophy (40.37%), followed by acute urine retention (20.69%) and micturition disorders (17.27%). The median Prostate Specific Antigen (PSA) was 188 ng/ml with extremes of 20 ng/ml and 2100 ng/ml. A large proportion of patients had a PSA between 100 and 500 ng/ml. Histologically, they were all prostatic acinar adenocarcinomas. These adenocarcinomas were well differentiated (48%) and moderately differentiated (38%). The predominant histoprognostic grade was ISUP (International Society of Urological Pathology) grade 1 which was noted in 65.52%, followed by grade 2 in 20.69%.

Conclusion

Prostate cancer in men under 50 years of age is relatively rare in Togo, sometimes occurring in the context of a family history of prostate cancer. Hence the importance of raising awareness among the male population, especially with a family history of prostate cancer, to start screening early, around the age of 40.