bluuebunny/crossref_metadata_2025 huggingface dataset:
The SWI/SNF chromatin remodeling factor DPF3 regulates metastasis of ccRCC by modulating TGF-β signaling
Authors: Cui Huanhuan , Yi Hongyang , Bao Hongyu , Tan Ying , Tian Chi , Shi Xinyao , Gan Diwen , Zhang Bin , Liang Weizheng , Chen Rui , Zhu Qionghua , Fang Liang , Gao Xin , Huang Hongda , Tian Ruijun , Sperling Silke R. , Hu Yuhui , Chen Wei
Published: August 2022

DPF3, a component of the SWI/SNF chromatin remodeling complex, has been associated with clear cell renal cell carcinoma (ccRCC) in a genome-wide association study. However, the functional role of DPF3 in ccRCC development and progression remains unknown. In this study, we demonstrate that DPF3a, the short isoform of DPF3, promotes kidney cancer cell migration both in vitro and in vivo, consistent with the clinical observation that DPF3a is significantly upregulated in ccRCC patients with metastases. Mechanistically, DPF3a specifically interacts with SNIP1, via which it forms a complex with SMAD4 and p300 histone acetyltransferase (HAT), the major transcriptional regulators of TGF-β signaling pathway. Moreover, the binding of DPF3a releases the repressive effect of SNIP1 on p300 HAT activity, leading to the increase in local histone acetylation and the activation of cell movement related genes. Overall, our findings reveal a metastasis-promoting function of DPF3, and further establish the link between SWI/SNF components and ccRCC.
Pro-oxidant response and accelerated ferroptosis caused by synergetic Au(I) release in hypercarbon-centered gold(I) cluster prodrugs
Authors: Xiao Kui , Zhang Niyuan , Li Feifei , Hou Dayong , Zhai Xiaoyi , Xu Wanhai , Wang Gelin , Wang Hao , Zhao Liang
Published: August 2022

Medicinal applications of gold complexes have recently attracted attention due to their innovative antitumor mechanisms. In this work, two hypercoordinated carbon-centered gold clusters PAA4 and PAA5 are quantitatively synthesized by an intramolecular 6-exo-dig cyclization of polymetalated precursors. The on-bench and in vitro experimental studies demonstrate that the characteristic hypercarbon-tetragold(I) multi-center bonding in PAA4 and PAA5 not only guarantees their stability under common physiological conditions, but also facilitates a glutathione (GSH)-triggered prompt and synergetic release of active Au(I) ions in the GSH-overexpressed and acidic microenvironment of human bladder cancer EJ cells. The instantly massive release of coordination unsaturated Au(I) ions causes the efficient inhibition of thioredoxin reductases and then induces a rapid pro-oxidant response, consequently causing the occurrence of accelerated ferroptosis of EJ cells. As a result, these hypercarbon-centered gold(I) cluster prodrugs show high cytotoxicity to bladder cancer cell lines and thus exhibit a significant inhibition effect towards bladder tumors in vivo. Correlation of the synergetic domino dissociation of carbon-polymetal multi-center bonding in metal clusters with the accelerated ferroptosis of cancer cells provides a strategy for metallo-prodrugs and opens a broader prospect for the biological application of metal cluster compounds.
Sequential process optimization for a digital light processing system to minimize trial and error
Authors: Choi Jae Won , Kim Gyeong-Ji , Hong Sukjoon , An Jeung Hee , Kim Baek-Jin , Ha Cheol Woo
Published: August 2022

In additive manufacturing, logical and efficient workflow optimization enables successful production and reduces cost and time. These attempts are essential for preventing fabrication problems from various causes. However, quantitative analysis and integrated management studies of fabrication issues using a digital light processing (DLP) system are insufficient. Therefore, an efficient optimization method is required to apply several materials and extend the application of the DLP system. This study proposes a sequential process optimization (SPO) to manage the initial adhesion, recoating, and exposure energy. The photopolymerization characteristics and viscosity of the photocurable resin were quantitatively analyzed through process conditions such as build plate speed, layer thickness, and exposure time. The ability of the proposed SPO was confirmed by fabricating an evaluation model using a biocompatible resin. Furthermore, the biocompatibility of the developed resin was verified through experiments. The existing DLP process requires several trials and errors in process optimization. Therefore, the fabrication results are different depending on the operator’s know-how. The use of the proposed SPO enables a systematic approach for optimizing the process conditions of a DLP system. As a result, the DLP system is expected to be more utilized.
Construction of a hypoxia-derived gene model to predict the prognosis and therapeutic response of head and neck squamous cell carcinoma
Authors: Wang Haibin , Zheng Lian
Published: August 2022

Head and neck squamous cell carcinoma (HNSCC) ranks as the sixth most common cancer worldwide and has a poor prognosis in the advanced stage. Increasing evidence has shown that hypoxia contributes to genetic alterations that have essential effects on the occurrence and progression of cancers. However, the exact roles hypoxia-related genes play in HNSCC remain unclear. In this study, we downloaded the mRNA expression profiles and clinical data of patients with HNSCC from The Cancer Genome Atlas and Gene Expression Omnibus. Two molecular subtypes were identified based on prognostic hypoxia-related genes using the ConsensusClusterPlus method. ESTIMATE was used to calculate the immune score of each patient. Kyoto Encyclopedia of Genes and Genomes and Gene Ontology were used for functional annotation. A prognostic risk model was generated by Cox regression and least absolute shrinkage and selection operator analysis. We identified two distinct molecular subtypes, cluster 1 and cluster 2, based on 200 hypoxia-related genes. Additionally, we identified three hypoxia-immune subgroups (hypoxia-high/immune-low, hypoxia-low/immune-high, and mixed subgroups). The hypoxia-high/immune-low group had the worst prognosis, while the hypoxia-low/immune-high group had the best prognosis. Patients in the hypoxia-low/immune-high group were more sensitive to anti-PD-L1 treatment and chemotherapy than those in the hypoxia-high/immune-low group. Furthermore, we constructed a prognostic risk model based on the differentially expressed genes between the hypoxia-immune subgroups. The survival analysis and time-dependent ROC analysis results demonstrated the good performance of the established 7-gene signature for predicting HNSCC prognosis. In conclusions, the constructed hypoxia-related model might serve as a promising biomarker for the diagnosis and prognosis of HNSCC, and it could predict immunotherapy and chemotherapy efficacy in HNSCC.
Catalysed amplification of faradaic shotgun tagging in ultrasensitive electrochemical immunoassays
Authors: Sharafeldin Mohamed , Hein Robert , Davis Jason J.
Published: August 2022

We introduce a novel electrochemical protein quantitation based on the shotgun biotin tagging of proteins prior to their interfacial immunocapture and polymeric enzyme tag recruitment.
Capturing nonclassical C70with double heptagons in low-pressure combustion
Authors: Xie Fang-Fang , Chen Zuo-Chang , Zhang Min , Xie Xiao-Ming , Chen Ling-Fang , Tian Han-Rui , Deng Shun-Liu , Xie Su-Yuan , Zheng Lan-Sun
Published: August 2022

A novel nonclassical fullerene dihept-C70H6, captured from low-pressure combustion, is considered to be vital evidence for the further study of heptafullerenes.
Assessing the impact of valence asymmetry in ionic solutions and its consequences on the performance of supercapacitors
Authors: Messias Andresa , Fileti Eudes E.
Published: August 2022

Molecular dynamics simulations were performed to describe the properties of hypothetical saline electrolyte solutions where we evaluated the effect of the asymmetric valence of these solutions on the performance of graphene supercapacitors.
Dynamically tunable bound states in the continuum supported by asymmetric Fabry–Pérot resonance
Authors: Gao Enduo , Li Hongjian , Liu Chao , Ruan Banxian , Li Min , Zhang Baihui , Zhang Zhenbin
Published: August 2022

The dynamic regulation of quasi-bound states in the continuum (quasi-BIC) is a research hotspot, such as incident angle, polarization angle, temperature, medium refractive index, and medium position regulation.
Scrutinizing particle size related bond strengthening in anatase TiO2
Authors: Yu Jinlong , Mamakhel Aref , Søndergaard-Pedersen Frederik , Ceccato Marcel , Iversen Bo Brummerstedt
Published: August 2022

Variations in the crystal structure and bond lengths of three anatase TiO2 samples with average crystallite sizes of 6 nm, 19 nm and several hundred nm, respectively, are due to hydroxyl defects rather than nanosize effects.
Efficient hydrogenation of CO2 to formic acid in water without consumption of a base
Authors: Ma Wentao , Hu Jinling , Zhou Lei , Wu Youting , Geng Jiao , Hu Xingbang
Published: August 2022

CO2 hydrogenation to formic acid was achieved without consumption of a base and a turnover number of up to 364 249 was obtained. HCOOH is isolatable and the catalyst–base system is easily recycled.
Ultra-rapid real-time microfluidic RT-PCR instrument for nucleic acid analysis
Authors: Nouwairi Renna L. , Cunha Larissa L. , Turiello Rachelle , Scott Orion , Hickey Jeff , Thomson Scott , Knowles Stuart , Chapman Jeff D. , Landers James P.
Published: August 2022

The described microfluidic instrument performs real-time PCR (40 cycles) with comparable sensitivity to commercial instrumentation in under 10 minutes.
Recent developments of sonodynamic therapy in antibacterial application
Authors: Wang Ruhao , Liu Qianwen , Gao Ang , Tang Ning , Zhang Qian , Zhang Amin , Cui Daxiang
Published: August 2022

This review summarizes the currently available sonosensitizers for antibacterial SDT and digs into innovative biotechnologies to improve SDT efficiency.
Research progress in the application of colloidal motors for precision medicine
Authors: Zhang Xiao , Yang Tingxin , Wu Yingjie , He Qiang
Published: August 2022

Colloidal motors have unique capabilities of self-propulsion, cargo loading and active target delivery, and have great potential for precision disease therapy.
Antibacterial hydrogels of aromatic tripeptides
Authors: Prakash Vivek , Christian Yvonne , Redkar Amay Sanjay , Roy Abhishek , Anandalakshmi R. , Ramakrishnan Vibin
Published: August 2022

Self-assembled peptide hydrogels have emerged as alternatives to the conventional approaches employed in controlled drug release, wound-healing, and drug delivery and as anti-infective agents.
Measuring human mesenchymal stem cell remodeling in hydrogels with a step-change in elastic modulus
Authors: McGlynn John A. , Schultz Kelly M.
Published: August 2022

Human mesenchymal stem cells are encapsulated in a hydrogel with a step-change in elastic modulus.The encapsulated cells respond to the change in stiffness and remodel the hydrogel differently based on local material properties.
Force-driven active dynamics of thin nanorods in unentangled polymer melts
Authors: Zhang Siteng , Wang Jiuling , Ge Ting
Published: August 2022

Molecular simulation and scaling theory demonstrate the combination of an anisotropic “skinny” shape and a strong external force enables a nano-needle to pierce through a polymer matrix with reduced viscous resistance.
A possible strategy for generating polymer chains with an entanglement-free structure
Authors: Lu Hui , Chen Ran , He Min-Wei , Liu Hong , Xue Yao-Hong
Published: August 2022

A possible strategy that may experimentally generate long polymeric chains with an entanglement-free structure is proposed in this study.
Binding of His-tagged fluorophores to lipid bilayers of giant vesicles
Authors: Pramanik Shreya , Steinkühler Jan , Dimova Rumiana , Spatz Joachim , Lipowsky Reinhard
Published: August 2022

Normalised fluorescence intensities of two His-tagged molecules, 6H-GFP and 6H-FITC, as functions of their molar concentrations. The solid curves depend on a single fit parameter, the equilibrium dissociation constants Kd.
Methane assisted catalyst synthesis and catalytic conversion of oleic acid
Authors: Jarvis Jack Samuel , Li Zhaofei , Meng Shijun , Song Hua
Published: August 2022

CH4-assisted synthesis of ZSM-5 enhances deoxygenation of oleic acid with methane as a co-reactant. Synthesis under CH4 environment produces a potential memory effect, yielding benzylic site and CO2 incorporation of the CH4 species.
Metal–organic framework derived Os-doped NixP/N-doped carbon composite nanosheet arrays toward boosting methanol oxidation into value-added chemicals coupled with hydrogen production
Authors: Duan Zhongyao , Ren Tianlun , Mao Qiqi , Yu Hongjie , Deng Kai , Xu You , Wang Ziqiang , Wang Liang , Wang Hongjing
Published: August 2022

An Os–NixP/N–C/NFIIOs–NixP/N–C/NF electrolyzer has been constructed for simultaneous H2 generation and formate electrosynthesis.
Humanoid control of lower limb exoskeleton robot based on human gait data with sliding mode neural network
Authors: Yu Jun , Zhang Shuaishuai , Wang Aihui , Li Wei , Ma Zhengxiang , Yue Xuebin
Published: August 2022

Lower limb exoskeleton robots offer an effective treatment for patients with lower extremity dysfunction. In order to improve the rehabilitation training effect based on the human motion mechanism, this paper proposes a humanoid sliding mode neural network controller based on the human gait. A humanoid model is constructed based on the human mechanism, and the parameterised gait trajectory is used as target to design the humanoid control system for robots. Considering the imprecision of the robot dynamics model, the neural network is adopted to compensate for the uncertain part of the model and improve the model accuracy. Moreover, the sliding mode control in the system improves the response speed, tracking performance, and stability of the control system. The Lyapunov stability analysis proves the stability of the control system theoretically. Meanwhile, an evaluation method using the similarity function is improved based on joint angle, velocity, and acceleration to evaluate the comfort of humans in rehabilitation training more reasonably. Finally, to verify the effectiveness of the proposed method, simulations are carried out based on experimental data. The results show that the control system could accurately track the target trajectory, of which the robot is highly similar to the human.
Cluster counts
Authors: Sakr Ziad , Ilić Stéphane , Blanchard Alain
Published: August 2022

Despite the success of the Lambda cold dark matter (ΛCDM) cosmological model, current estimations of the amplitude of matter fluctuations (σ8) show an appreciable difference between its value inferred from the cosmic microwave background (CMB) angular power spectrum (Cℓ) and those obtained from cluster counts. Neutrinos or a modification of the growth of structures had been previously investigated as the possible origin of this discrepancy. In this work we examine whether further extensions to the ΛCDM model could alleviate the tension. To this end, we derived constraints on the parameters subject to the discrepancy, using CMB Cℓ combined with cluster counts from the Sunyaev–Zel’dovich (SZ) sample with a free dark energy equation of state parameter, while allowing the cluster mass calibration parameter (1 − b) to vary. This latter is degenerate with σ8, which translates the discrepancy within the ΛCDM framework into one between (1 − b)∼0.6, corresponding to constraints on σ8 obtained from CMB, and (1 − b)∼0.8, the value adopted for the SZ sample calibration. We find that a constant w, when left free to vary along with large priors on the matter density ([0.1, 1.0]) and the Hubble parameters ([30, 200]), can reduce the discrepancy to less than 2σ for values far below its fiducial w = −1. However, such low values of w are not allowed when we add other probes like the baryonic acoustic oscillation (BAO) feature angular diameter distance measured in galaxy clustering surveys. We also found, when we allow to vary in addition to w a modification of the growth rate through the growth index γ, that the tension is alleviated, with the (1 − b) likelihood now centred around the Planck calibration value of ∼0.8. However, here again, combining CMB and cluster counts with geometrical distance probes restores the discrepancy, with the (1 − b) preferred value reverting back to the ΛCDM value of ∼0.6. The same situation is observed when introducing, along with w and γ, further extensions to ΛCDM (e.g., massive neutrinos), although these extensions reduce the tension to 2σ, even when combined with BAO datasets. We also explore other common extensions by comparing two cases: allowing a dynamical w following a CPL parametrisation in addition to a constant growth index, and when the growth index is expanded through a second parameter γ1 along with a constant w. In the former we reach the same conclusions as with the case of a constant w and γ, where the discrepancy was alleviated only if we do not constrain w by BAO, while in the latter case, we observe that introducing γ1 drives (1 − b) towards lower values that would instead increase the discrepancy on σ8. We conclude that none of these common extensions to ΛCDM is able to fix the discrepancy and a misdetermination of the calibration factor is the most preferred explanation. Finally, we investigate the effect on our posteriors from limiting the Hubble constant priors to the usual common adopted range of [30, 100].
The Radcliffe wave as the gas spine of the Orion arm
Authors: Swiggum C. , Alves J. , D’Onghia E. , Benjamin R. A. , Thulasidharan L. , Zucker C. , Poggio E. , Drimmel R. , Gallagher III J. S. , Goodman A.
Published: August 2022

The Radcliffe wave is a ∼3 kpc long coherent gas structure containing most of the star-forming complexes near the Sun. In this Letter we aim to find a Galactic context for the Radcliffe wave by looking into a possible relationship between the gas structure and the Orion (local) arm. We use catalogs of massive stars and young open clusters based on Gaia Early Data Release 3 (EDR3) astrometry, in conjunction with kiloparsec-scale 3D dust maps, to investigate the Galactic XY spatial distributions of gas and young stars. We find a quasi-parallel offset between the luminous blue stars and the Radcliffe wave, in that massive stars and clusters are found essentially inside and downstream from the Radcliffe wave. We examine this offset in the context of color gradients observed in the spiral arms of external galaxies, where the interplay between density wave theory, spiral shocks, and triggered star formation has been used to interpret this particular arrangement of gas and dust as well as OB stars, and outline other potential explanations as well. We hypothesize that the Radcliffe wave constitutes the gas reservoir of the Orion (local) arm, and that it presents itself as a prime laboratory to study the interface between Galactic structure, the formation of molecular clouds in the Milky Way, and star formation.
PRUSSIC
Authors: Rybak M. , Hodge J. A. , Greve T. R. , Riechers D. , Lamperti I. , van Marrewijk J. , Walter F. , Wagg J. , van der Werf P. P.
Published: August 2022

Dusty star-forming galaxies (DSFGs) at redshiftz ≥ 1 are among the most vigorously star-forming galaxies in the Universe. However, their dense (≥105cm−3) gas phase – typically traced by HCN(1–0) – remains almost entirely unexplored: only two DSFGs have been detected in HCN(1–0) to date. We present the results of aKarl G. JanskyVery Large Array survey of theJ = 1–0 transition of HCN, HCO+, and HNC(1–0) in six strongly lensed DSFGs atz = 2.5 − 3.3, effectively doubling the number of DSFGs with deep observations of these lines. We detect HCN(1–0) emission in one source (J1202+5354, 4.6σ), with a tentative HCO+(1–0) detection in another (J1609+6045, 3.3σ). Spectral stacking yields strict upper limits on the HCN/FIR (≤3.6 × 10−4) and HCN/CO(1–0) ratios (≤0.045). The inferred HCN/FIR ratios (a proxy for the star-formation efficiency) are consistent with those inz ∼ 0 far-infrared-luminous starbursts. However, the HCN/CO ratios – a proxy for the dense-gas fraction – are a factor of a few lower than suggested by the two previous DSFG detections. Our results imply that most DSFGs have low dense-gas fractions. A comparison with theoretical models of star-forming galaxies indicates that the bulk of gas in DSFGs is at lower densities (≈102cm−3), similar to ‘normal’ star-forming galaxies, rather than ultraluminous starbursts.
The activity concentrations of radionuclides 226Ra, 232Th and 40K of soil samples in the case of Metekel Zone, Ethiopia
Authors: Abate Tadesse
Published: August 2022

In this paper, we have studied the concentration levels and corresponding radiological hazard indices of natural radioactive elements such as radium-226, thorium-232, and potassium-40 in soil samples collected from Metekel Zone, Ethiopia. We have determined the concentration levels with the help of gamma ray spectrometry. Accordingly, we obtained the average values for radioactive concentrations of radium, thorium, and potassium to be 64 Bq/kg, 70 Bq/kg, and 330 Bq/kg, respectively. The radiological hazard has been also determined from the pertinent concentration levels of radium, thorium and potassium isotopes. Therefore, we obtained that the radioisotopes have heterogeneous distribution which must be caused by the nature and types of the soil in the area where this investigation was conducted for.
Prevalence of Impairment of Visual Acuity and Severity of Retinopathy
in Patients with Diabetes Mellitus
Authors: Cleemen Constantin , Müller Nicolle , Lehmann Thomas , Voigt Ulrich A. , Meller Daniel , Kloos Christof , Wolf Gunter , Müller Ulrich A , Voigt Margarete
Published: August 2022

Aims No information exists on the frequency of visual impairment in people
with diabetes mellitus (DM) in Germany. In this study, the prevalence of vision
impairment in those individuals was investigated.

Methods We retrospectively analyzed a cohort of 295 people (14221
consultations) at a university outpatient clinic with any type of DM and an
available ETDRS-Score and visual acuity. The primary outcome was the prevalence
of visual impairment, the secondary outcome was the correlation of the
ETDRS-Score and limitations of visual acuity and the prevalence of higher
ETDRS-Score with a visual impairment defined as a
decimal-visus</=0.3.

Results The prevalence of visual impairment in participants with DM was
11.2%; among these individuals, 81.8% had no or
non-proliferative retinopathy. In the DM2 subgroup, 81.5% (n=22)
of the visually impaired participants had no DR, in contrast to only
16.7% (n=1) in the DM1 subgroup. Progression in ETDRS-Score led
to worse visual acuity (r=−0.209; p<0.001). A
significantly related covariates with impairment of the visual acuity for
individuals with DM1 was the duration of diabetes (B=−0.007;
p=0.001) and for individuals with DM2, the age
(B=−0.008; p=0.009).

Conclusions The prevalence of impaired vision in people with diabetes in
our cohort was 11.2%,<20% of visual impairment in people
with diabetes is caused by diabetic retinopathy, and 69.7% of
participants with visual impairment had no DR. In our study patients without
visual impairment showed a similar distribution of DR severity levels regardless
of the type of diabetes.
Linguale Behandlung bei Patienten mit Molaren-Inzisiven
Hypomineralisation
Authors: Richter Susanna Isabel , Kopp Svenja Lina , Gerberding Elena , Beyling Frauke
Published: August 2022

Klinische Fallbeispiele (Non-Ex und Ex) bei ausgeprägter
Molaren-Inzisiven Hypomineralisation unter Verwendung einer
vollständig individuellen lingualen Apparatur.
Ring-Rearrangement Metathetic Approach to Fused 6/5/6/5/6-Oxacyclic Ring System and Bipentalene Derivatives
Authors: Kotha Sambasivarao , Jena Kunkumita
Published: August 2022

We have developed a useful synthetic route to a 6/5/6/5/6-oxacyclic ring system and bipentalene derivatives from dimeric 7-oxonorbornene derivatives by using ring-rearrangement metathesis as a key step. This method provides access to fused oxacycles containing eight stereogenic centers in just three steps and to bipentalene derivatives in two steps only.
The Effect of Centella asiatica Methanolic Extract on Expression of IL-1β Proinflammatory Cytokines in Severe Early Childhood Caries
Authors: Luthfi Muhammad , Razak Fathillah Abdul , Kusumawardhani Devy Putri , Nagoro Ayu Anggraini Broto , Fadhila Naura
Published: August 2022

Objective This article analyzes the role of C. asiatica extract in reducing the proinflammatory cytokine interleukin (IL)-1β produced by salivary neutrophils.

Material and Methods Selected kindergartens in the Surabaya area provided samples. The sample was initially checked for dental caries by measuring its def-t index, and then the participants who satisfied the requirements for severe caries with a def-t of greater than 6 were chosen. At the time of sampling, all of the individuals were between the ages of 4 and 6. The sampling was performed by researchers and certified persons using well-known methodologies. For 60 minutes before to sampling, respondents were not allowed to eat, drink, chew gum, or brush their teeth. For analysis, the samples were collected and then frozen at −80°C.

Results The administration of methanolic extract C. asiatica decreased the expression of the proinflammatory cytokine IL-1β on the surface of salivary neutrophils on S-ECC; The administration of C. asiatica methanol extract resulted in a decrease in the expression of the proinflammatory cytokine IL-1β on the surface of salivary neutrophils in S-ECC.

Conclusion C. asiatica extract has the effect of reducing the proinflammatory cytokine IL-1β produced by salivary neutrophils on S-ECC via inhibiting nuclear factor kappa B and mitogen–activated protein kinase signaling pathway activation and suggest that C. asiatica is a possible candidate for treating S-ECC.
How Common is Subsequent Posterior Tibial Tendon Dysfunction or Tarsal Tunnel Syndrome After Ankle Sprain Injury?
Authors: Foster Kaitlyn S. , Greenlee Tina A. , Young Jodi L. , Janney Cory F. , Rhon Daniel I.
Published: August 2022

Posterior tibial tendon dysfunction (PTTD) and tarsal tunnel syndrome (TTS) are debilitating conditions reported to occur after ankle sprain due to their proximity to the ankle complex. The objective of this study was to investigate the incidence of PTTD and TTS in the 2 years following an ankle sprain and which variables are associated with its onset. In total, 22,966 individuals in the Military Health System diagnosed with ankle sprain between 2010 and 2011 were followed for 2 years. The incidence of PTTD and TTS after ankle sprain was identified. Binary logistic regression was used to identify potential demographic or medical history factors associated with PTTD or TTS. In total, 617 (2.7%) received a PTTD diagnosis and 127 (0.6%) received a TTS diagnosis. Active-duty status (odds ratio [OR] 2.18, 95% confidence interval [CI] 1.70–2.79), increasing age (OR 1.03, 95% CI 1.02–1.04), female sex (OR 1.58, 95% CI 1.28–1.95), and if the sprain location was specified by the diagnosis (versus unspecified location) and did not include a fracture contributed to significantly higher (p < 0.001) risk of developing PTTD. Greater age (OR 1.06, 95% CI 1.03–1.09), female sex (OR 2.73, 95% CI 1.74–4.29), history of metabolic syndrome (OR 1.73, 95% CI 1.03–2.89), and active-duty status (OR 2.28, 95% CI 1.38–3.77) also significantly increased the odds of developing TTS, while sustaining a concurrent ankle fracture with the initial ankle sprain (OR 0.45, 95% CI 0.28–0.70) significantly decreased the odds. PTTD and TTS were not common after ankle sprain. However, they still merit consideration as postinjury sequelae, especially in patients with persistent symptoms. Increasing age, type of sprain, female sex, metabolic syndrome, and active-duty status were all significantly associated with the development of one or both subsequent injuries. This work provides normative data for incidence rates of these subsequent injuries and can help increase awareness of these conditions, leading to improved management of refractory ankle sprain injuries.
Impact of a Retained Instrument on Treatment Outcome: A Systematic Review
Authors: Rao Lakshmi Nidhi , Thirunarayanan Sembaga Lakshmi , Shetty Aditya
Published: August 2022

Instrument separation during endodontic therapy is a frequent accident with rotary instruments being more likely to separate than manual ones. There are various treatment options when the instrument separates in a canal depending on the location, complexity of the canal anatomy, and the operators' ability. The success of the tooth that has a retained fragment of instrument in the canal has been assessed in various studies but no clear conclusion has been drawn. The goal of this systematic review is to answer as many questions as possible. Does the retention of a separated instrument, compared with no retained separated instrument, result in a worse clinical outcome in adult patients who have received nonsurgical root canal treatment?

Materials and Methodology The search was conducted with the boolean terms in various database following the PRISMA guidelines. The inclusion and exclusion criteria were set for the inclusion of the study for the systematic review.

Results Out of the 330 articles that were obtained, 28 were duplicates. After screening for eligibility, only 7 articles were retrieved for full text. When inclusion and exclusion criteria were applied, none of the studies could be included.

Conclusion There is still a lack of consensus on the treatment option for a separated instrument and there is no clear evidence to suggest whether the prognosis of the tooth with retained instrument is reduced or not.
Human Immunodeficiency Virus Status Does Not Independently Predict 2-Year Complications Following Total Knee Arthroplasty
Authors: Elzomor Amir , Malyavko Alisa , Agarwal Amil R. , Cohen Jordan S. , Campbell Joshua , Golladay Gregory J. , Thakkar Savyasachi C.
Published: August 2022

With improved treatment for human immunodeficiency virus (HIV), the demand for total knee arthroplasty (TKA) in this population has increased. Studying the relationship between HIV and postoperative complications following TKA will allow orthopaedic surgeons to accurately assess their patients' surgical risk and provide appropriate counseling. This study aims to understand how HIV impacts surgical and medical complications following TKA for osteoarthritis (OA). Patients identified in a national insurance database who underwent TKA for OA from 2010 to 2019 were divided into three cohorts: no HIV, asymptomatic HIV, and acquired immunodeficiency syndrome (AIDS). Univariate and multivariable regression analyses were performed to determine 90-day postoperative complications as well as 2-year surgical complications (revision surgery, prosthetic joint infection, aseptic loosening, and manipulation under anesthesia). A total of 855,373 patients were included, of whom 1,338 had asymptomatic HIV and 268 had AIDS. After multivariable regression analysis, patients with HIV had no difference in 2-year surgical complications relative to the control cohort. Within 90 days postoperatively, patients with asymptomatic HIV had increased odds of arrhythmia without atrial fibrillation and lower odds of anemia. Patients with AIDS had increased odds of anemia and renal failure. Patients with HIV and AIDS are at an increased risk for developing 90-day medical complications and 2-year surgical complications. However, after accounting for their comorbidities, the risk of 90-day complications was only mildly increased and the risk of 2-year surgical complications approximated the control cohort. Surgeons should pay particular attention to these patients' overall comorbidities, which appear to be more closely associated with postoperative risks than HIV status alone. Level of evidence: III.
Quantum machine learning corrects classical forcefields: Stretching DNA base pairs in explicit solvent
Authors: Berryman Joshua T. , Taghavi Amirhossein , Mazur Florian , Tkatchenko Alexandre
Published: August 2022

In order to improve the accuracy of molecular dynamics simulations, classical forcefields are supplemented with a kernel-based machine learning method trained on quantum-mechanical fragment energies. As an example application, a potential-energy surface is generalized for a small DNA duplex, taking into account explicit solvation and long-range electron exchange–correlation effects. A long-standing problem in molecular science is that experimental studies of the structural and thermodynamic behavior of DNA under tension are not well confirmed by simulation; study of the potential energy vs extension taking into account a novel correction shows that leading classical DNA models have excessive stiffness with respect to stretching. This discrepancy is found to be common across multiple forcefields. The quantum correction is in qualitative agreement with the experimental thermodynamics for larger DNA double helices, providing a candidate explanation for the general and long-standing discrepancy between single molecule stretching experiments and classical calculations of DNA stretching. The new dataset of quantum calculations should facilitate multiple types of nucleic acid simulation, and the associated Kernel Modified Molecular Dynamics method (KMMD) is applicable to biomolecular simulations in general. KMMD is made available as part of the AMBER22 simulation software.
A model of TaOx threshold switching memristor for neuromorphic computing
Authors: Li Xing , Feng Zhe , Zou Jianxun , Wang Xu , Hu Guyue , Wang Feifei , Ding Cheng , Zhu Yunlai , Yang Fei , Wu Zuheng , Dai Yuehua
Published: August 2022

In this article, we analyzed the experimental data based on the TaOx memristor and found that the threshold switching (TS) characteristics are related to temperature, and its logarithmic I–V curve is in good agreement with the space charge limiting current conduction mechanism. We use this mechanism to establish a TS physical model and then use the physical model to build an LTspice model. The model data are fitted with the experimental data, which is basically consistent. Next, using the TS memristor to simulate a leaky integrate-and-fire neuron circuit, the basic dynamics are realized. By changing the external temperature of the memristor, the output frequency of the neuron will be more intense as the temperature increases. Finally, an artificial spiking neural network (SNN) was built based on this neuron circuit for MNIST recognition task. In this SNN, the input signals fused both voltage amplitude and temperature to achieve neuromorphic multimodal preprocessing and enhance the recognition accuracy. These results demonstrated the reliability of the model, which enhanced the flexibility for exploring the application of TaOx-based TS memristors.
Diffusion coefficient and power spectrum of active particles with a microscopically reversible mechanism of self-propelling
Authors: Ryabov Artem , Tasinkevych Mykola
Published: August 2022

Catalytically active macromolecules are envisioned as key building blocks in the development of artificial nanomotors. However, theory and experiments report conflicting findings regarding their dynamics. The lack of consensus is mostly caused by the limited understanding of the specifics of self-propulsion mechanisms at the nanoscale. Here, we study a generic model of a self-propelled nanoparticle that does not rely on a particular mechanism. Instead, its main assumption is the fundamental symmetry of microscopic dynamics of chemical reactions: the principle of microscopic reversibility. Significant consequences of this assumption arise if we subject the particle to the action of an external time-periodic force. The particle diffusion coefficient then becomes enhanced compared to the unbiased dynamics. The enhancement can be controlled by the force amplitude and frequency. We also derive the power spectrum of particle trajectories. Among the new effects stemming from the microscopic reversibility are the enhancement of the spectrum at all frequencies and sigmoid-shaped transitions and a peak at characteristic frequencies of rotational diffusion and external forcing. Microscopic reversibility is a generic property of a broad class of chemical reactions. Therefore, we expect that the presented results will motivate new experimental studies aimed at testing our predictions. This could provide new insights into the dynamics of catalytic macromolecules.
Energy dispersive x-ray diffraction of luminescent powders: A complement to visible phosphor thermometry
Authors: Hansen L. E. , Westphal E. R. , Kastengren A. L. , Winters C.
Published: August 2022

Energy-dispersive x-ray diffraction of thermographic phosphors has been explored as a complementary temperature diagnostic to visible phosphor thermometry in environments where the temperature-dependent optical luminescence of the phosphors is occluded. Powder phosphor samples were heated from ambient to 300 °C in incremental steps and probed with polychromatic synchrotron x rays; scattered photons were collected at a fixed diffraction angle of 3.9°. Crystal structure, lattice parameters, and coefficients of thermal expansion were calculated from the diffraction data. Of the several phosphors surveyed, YAG:Dy, ZnO:Ga, and GOS:Tb were found to be excellent candidates for diffraction thermometry due to their strong, distinct diffraction peaks that shift in a repeatable and linear manner with temperature.
3D transient MHD simulation of DC breaking vacuum arc based on artificial current zero
Authors: Wang Lijun , Zhang Zhefeng , Chen Jieli , Yang Ze , Jiang Jing , Wang Hongda , Jia Shenli
Published: August 2022

In the vacuum DC circuit breaker based on the artificial current zero, the change of arc luminosity delays the change of current value significantly in the fast current-zero stage. This phenomenon has impacts on the breaking capacity of the DC vacuum circuit breaker. Therefore, it is necessary to study the dynamic characteristics of the arc plasma under the above condition. In this work, a 3D transient magneto-hydro-dynamic model based on the commercial cup-type axial magnetic field (AMF) contact is established to study this phenomenon. The simulation results show that the fast current-zero stage is too short for the plasma to diffuse. The changes of the physical characteristics of the arc plasma lag the change of current value. Moreover, the magnetic field hysteresis caused by the eddy current on the electrode occurs in this stage, resulting in a continuous stronger AMF. It makes the distributions of the plasma uniform, while the diffusion of the arc plasma reduced at low currents, which is detrimental to the post-arc dielectric recovery stage. In addition, in the fast current-zero stage, the AMF near the contact slot is smaller than in other areas. This indicates that the slotting is effective in suppressing eddy currents and avoiding the negative effect of excessive AMF on plasma diffusion at this stage. The simulation results are consistent with the experimental results.
Some new insights for inferring diapycnal (irreversible) diffusivity in stably stratified turbulence
Authors: Garanaik Amrapalli , Venayagamoorthy Subhas Karan
Published: August 2022

New insight for inferring diapycnal diffusivity in stably stratified turbulent flows is obtained based on physical scaling arguments and tested using high-resolution direct numerical simulation data. It is shown that the irreversible diapycnal diffusivity can be decomposed into a diapycnal length scale that represents an inner scale of turbulence and a diapycnal velocity scale. Furthermore, it is shown that the diapycnal length scale and velocity scale can be related to the measurable Ellison length scale (LE) that represents outer scale of turbulence and vertical turbulent velocity scale (w′) through a turbulent Froude number scaling analysis. The turbulent Froude number is defined as Fr=ε/Nk, where ε is the rate of dissipation of turbulent kinetic energy, N is the buoyancy frequency, and k is the turbulent kinetic energy. The scaling analysis suggests that the diapycnal diffusivity Kρ∼w′LE in the weakly stratified regime (Fr >1) and Kρ∼(w′LE)×Fr for the strongly stratified regime (Fr <1).
Resonance frequency above 20 GHz in superparamagnetic NiZn-ferrite
Authors: Arackal Sarath , Nozawa Kouhei , Kahmei Ralandinliu , Loi Ton That , Yabukami Shin , Shivashankar S. A. , Yamaguchi Masahiro , Bhat Navakanta , Sai Ranajit
Published: August 2022

We investigate the frequency dispersion of complex permeability in the GHz range in superparamagnetic nickel–zinc ferrite thin films with different Ni/Zn ratios using a microstrip probe. The films, comprising crystallites as small as 3 nm and deposited by a microwave-irradiation-assisted solvothermal method, exhibit the coexistence of two resonance characteristics—a ferromagnetic resonance peak (fr) at ∼2 GHz and a superparamagnetic resonance peak (fb) above 20 GHz, breaching Snoek's limit. The high value of fr is attributed to the high surface anisotropy and far-from-equilibrium distribution of cations in the lattice, while fb is attributed to the thermally driven superparamagnetic relaxation of ferrite nanocrystallites in the thin films. This work demonstrates the feasibility of employing superparamagnetic ferrite thin films so deposited as excellent CMOS-integrable magnetic components for high-speed and high-frequency electromagnetic device applications.
Two bridge-particle-mediated RET between chiral molecules
Authors: Salam A.
Published: August 2022

The problem of resonance energy transfer between a pair of chiral molecules mediated by two electrically polarizable bridging particles is solved using molecular quantum electrodynamics theory. In this framework, a single virtual photon propagates between any two-coupled entities and is responsible for the conveyance of excitation energy from the emitter to the absorber. Electric dipole and quadrupole, and magnetic dipole couplings linear in the Maxwell fields are employed for donor and acceptor, while each mediator scatters two virtual photons and responds quadratically to the electric displacement field via its electric dipole polarizability. This enables fourth-order diagrammatic perturbation theory to be used to compute the probability amplitude for the process. Individual multipole moment contributions to the Fermi golden rule rate are then extracted for oriented and isotropic systems. Discriminatory transfer rates arise when either the donor or the acceptor are electric–magnetic dipole and the other has a pure multipole moment, or when both are chiral, with mixed electric dipole–quadrupole contributions vanishing in the fluid phase. The bridge-mediated transfer rate is found to be a maximum for a collinear geometry. Moreover, a multi-level model of the mediator is necessary for energy migration. Asymptotically limiting rates for arbitrary and collinear geometries are also obtained for one center purely electric dipolar and the other purely quadrupolar, or both donor and absorber purely quadrupolar. Understanding is gained of radiationless and radiative transfer mechanisms between chiral moieties in a dielectric medium.
You don’t get to see that every day
Authors: Hilpert Martin , Perek Florent
Published: August 2022

This paper contributes to the study of grammaticalization phenomena from the perspective of Construction Grammar (Coussé et al. 2018). It is concerned with modal uses of the English verbgetthat express a permitted action, as inThe prisoners always get to make one phone call. Different views exist on the contexts in which permissivegetemerged. Gronemeyer (1999: 30) suggests that the permissive meaning derives from causative uses (I got him to confess). An alternative is proposed by van der Auwera et al. (2009: 283), who view permissivegetas an extension of its acquisitive meaning (I got a present). We revisit these claims in the light of recent historical data from American English. Specifically, we searched the COHA (Davies 2010) for forms ofgetfollowed bytoand a verb in the infinitive. Besides examples of permissiveget, we retrieved examples of obligativegot to(I got to leave), causativeget(Who did you get to confess?), possessivegot(What have I got to be ashamed of?), and a category that we label inchoativeget(You’re getting to be a big girl now). Drawing on distributional semantic techniques (Perek 2016,2018), we analyse how permissivegetand inchoativegetdeveloped semantically over time. Our results are consistent with an account that represents an alternative to bothGronemeyer (1999)andvan der Auwera et al. (2009), namely the idea that permissivegetevolved out of inchoative uses that invited the idea of a permission.
Cross-cultural dialogue in the Polish-English translation of neologisms
Authors: Salich Hanna
Published: August 2022

The article discusses selected neologisms that Stanisław Lem, a Polish science-fiction writer, created for two of his numerous short stories featuring Ijon Tichy, a space traveler. It is not only their surprising and appealing structure that makes these creations and their English counterparts an interesting subject for analysis, but also, and more importantly, the fact that they carry specific allusions, which renders them humorous in their contextual appearance. All these characteristics contribute to a translation challenge present in the neologisms analyzed. The article focuses on how – and with what result – this challenge has been approached by the translators who handled it in an endeavor to expand the dialogic space between the author and his audience.
Modeling the behavior of two-electron atom at critical nuclear charge
Authors: Zheng Ruo Yu , Jiao Li Guang , Liu Aihua , Ma Jia , Montgomery H E , Ho Yew Kam
Published: August 2022

The expectation values of radial and angular quantities for two-electron atoms at the critical nuclear charge where the ground state ceases to exist are calculated employing the Hylleraas-configuration interaction basis functions. The radial quantities achieve better convergence than previous predictions and accurate angular quantities are reported for the first time. Based on these quantities, the geometric structure of the system is examined to support the criteria that the critical behavior of the system can be modeled by the inner and outer electrons separately. The work of King et al (2016 Phys. Rev. A 93 022509) has shown that the inner-electron probability density distribution closely resembles that of a hydrogenic atom. Here we further show that the outer electron can be reasonably modeled by a shifted exponential polarization potential with soft truncation in the short range. The model potential proposed here reproduces very well the radial expectation value of the outer electron as well as the peak position, maximum magnitude, and long-range asymptotic behavior of the outer-electron radial density distribution.
Structural transformations and thermal stability of RhGe synthesized under high temperature and pressure
Authors: Kamaeva L V , Magnitskaya M V , Suslov A A , Tsvyashchenko A V , Chtchelkatchev N M
Published: August 2022

Here, we study B20-type RhGe, a representative of a class of non-centrosymmetric monosilicides and monogermanides, which possess unique topological and magnetic properties important for many possible applications. The stability and phase transitions of the non-equilibrium B20-RhGe phase that can only be obtained under high pressure, are investigated theoretically using ab initio calculations and experimentally by means of differential scanning calorimetry. For RhGe and, for comparison, for its analogue RhSi, we conducted an evolutionary search for low-energy polymorphic modifications at zero temperature and then performed simulations of their behavior at finite temperatures. The (

P
,
T

) conditions of stability for the found polymorphs are determined. Our calorimetric studies on high-pressure-synthesized RhGe samples allowed us to reveal peculiarities in thermal stability and heating-induced phase transformations. X-ray diffraction analysis and microstructure analysis of the samples were carried out before and after the heating. We also determined the specific heat from calorimetric measurements and compared the results with our calculations in the quasi-harmonic approximation.