bluuebunny/crossref_metadata_2025 huggingface dataset:
Pengaruh PDRB dan Tingkat Suku Bunga Riil Terhadap Permintaan Kredit Investasi Pada Bank Umum di Provinsi Bali Periode 2014-2018
Authors: Riantara I Kadek Yoga , Yasa Putu Ngurah Suyatna , Purnami A. A Sri
Published: November 2022

Kredit Investasi merupakan kredit yang dipergunakan oleh masyarakat untuk pembelian atau pembiayaan barang-barang modal dalam rangka pembangunan proyek baru, modernisasi. Dimana kredit investasi di Provinsi Bali pada tahun 2014 sampai dengan tahun 2018 mengalami fluktuatif tiap tahunnya.Tujuan dari penelitian ini adalah untuk mengetahui PDRB dan suku bunga riil terhadap permintaan kredit investasi secara serempak dan parsial pada Bank umum di Provinsi Bali. Analisis data yang digunakan uji asumsi metode regresi linier klasik dan berganda. Hasil penelitian yaitu dari uji F nilai sig. 0,000 < 0,05 yang berarti diperoleh secara serempak variabel PDRB dan suku bunga riil berpengaruh signifikan terhadap permintaan kredit investasi. Dari uji t pada variabel PDRB mempunyai pengaruh positif dan signifikan terhadap permintaan kredit investasi, dari uji t pada variabel suku bunga riil mempunyai pengaruh negatif dan signifikan terhadap permintaan kredit investasi.
Pengaruh Komponen Indeks Pembangunan manusia Terhadap Pertumbuhan ekonomi Kabupaten / Kota di Bali Tahun 2012-2019
Authors: Giri Ni Komang Octavia , Yasa Putu Ngurah Suyatna , Jayawarsa A.A. Ketut
Published: November 2022

Pembangunan manusia merupakan salah satu indicator tercapainya pembangunan ekonomi. Walaupun pembangunan manusia meningkat setiap tahunnya dari tahun, tetapi ketimpangan pembangunan manusia masih terlihat antar Kabupaten/Kota Provinsi Bali. Penelitian ini bertujuan untuk mengetahui pengaruh angka harapan hidup, angka melek huruf,  rata-rata lama sekolah dan pengeluaran rill terhdap pertumbuhan ekonomi. Data yang digunakan adalah data sekunder yang di unduh dari Badan Pusat Statistik Provinsi Bali dan bersifat time series 2012 - 2019. Metode yang akan digunakan dalam menganalisis data dalam penelitian ini adalah menggunakan metode analisis deskriptif dan  kuantitatif. Berdasarkan hasil olah data, diperoleh bahwa angka harapan hidup berpengaruh positif terhadap pertumbuhan ekonomi, angka melek huruf berpengaruh negatif terhadap pertumbuhan ekonomi, rata-rata lama sekolah berpengaruh positif tidak signifikan terhdap pertumbuhan ekonomi, dan pengeluaran riil perkapita berpengaruh negative signifikan terhadap pertumbuhan ekonomi Kabupaten/Kota di Bali. Untuk Pemerintah diharapkan lebih meningkatkan kinerja yang mampu meningkatkan kualitas pendidikan Kabupaten/Kota di Bali. Tingkat Pendidikan harusdiperhatikanlebihserius demi meningkatkan pertumbuhan ekonomi yang lebih baik, serta pengeluaran perkapita perlu di stabilkan kembali tiap tahunnya.
EDUKASI KESEHATAN DAN KESELAMATAN KERJA DI PASAR IKAN KEDONGANAN, BALI
Authors: Cahyawati (Scopus ID: 57203956416) Putu Nita , Kasih Pande Ayu Naya , Aryastuti Anak Agung Sri Agung , Udiyani Desak Putu Citra , Pandit I Gde Suranaya
Published: November 2022

Pasar tradisional merupakan salah satu pilar perekonomian daerah di Indonesia. Salah satu pasar tradisional di Bali adalah Pasar Ikan Kedonganan. Lokasinya yang strategis memungkinkan pasar ini dikunjungi oleh wisatawan domestik maupun internasional. Pedagang pasar tradisional merupakan kelompok masayarakat yang sangat rentan mengalamai risiko kesehatan dan keselamatan kerja khususnya selama pandemi Covid-19. Hal ini dikarenakan jarak fisik antara pedagang dan pembeli yang sangat dekat, ruang kerja terbatas, penggunaan alat pelindung diri yang minim, serta kebersihan yang buruk. Kurangnya informasi kesehatan dan perkembangan kesehatan kerja pada sektor informal ini merupakan salah satu pemicu terjadinya permasalahan tersebut. Kegiatan pengabdian pada kelompok pedagang di Pasar Ikan Kedonganan ini bertujuan untuk meningkatkan pengetahuan mitra tentang kesehatan dan keselamatan kerja. Kegiatan diawali oleh diskusi, penyuluhan, dan evaluasi. Hasil kegiatan menemukan bahwa partisipasi mitra selama kegiatan sangat baik (100%). Kegiatan penyuluhan juga dapat meningkatan pengetahuan mitra. Hal ini dinilai berdasarkan hasil nilai pretest dan posttest. Nilai pretest sebelum kegiatan adalah 18,82 dan nilai posttest pada akhir kegiatan yaitu 40. Peningkatan pengetahuan mencapai 2 kali lipat dari nilai awal namun belum mencapai nilai 70. Kesimpulan yang diperoleh antara lain pelaksanaan kegiatan telah berlangsung dengan baik sesuai dengan rencana. Terdapat peningkatan nilai prettest dan posttest dari 18,82 poin pada awal kegiatan menjadi 40 poin pada akhir kegiatan. Walaupun demikian, diperlukan upaya berkesinambungan dalam mendampingi mitra dalam penerapan edukasi yang telah diberikan.
IDENTIFIKASI PENGEMBANGAN EKOWISATA DI DESA BUKIAN, KECAMATAN PAYANGAN, KABUPATEN GIANYAR
Authors: Luxiana I Wayan Suky , Parwata I Wayan , Kurniawan Agus
Published: November 2022

Desa Bukian merupakan salah satu desa di Kabupaten Gianyar yang memiliki potensi yang beragam mulai dari budaya, alam, buatan dan dapat dikembangkan melalui konsep ekowisata sebagai tujuan atau daya tarik wisata. Tujuan dari penelitian ini adalah untuk mengidentifikasi pengembangan ekowisata. Lokasi penelitian ini berada di desa Bukian yang memiliki lokasi terintegrasi dengan pertanian dan pariwisata. Penelitian di desa Bukian dilakukan untuk mengidentifikasi potensi desa (potensi budaya, alam, dan buatan desa). Penelitian ini menggunakan teknik observasi, wawancara, dan dokumentasi. Teknik analisis data yang digunakan adalah analisis deskriptif kualitatif. Tujuan teknik pengambilan sampel menggunakan informan dan menggunakan informan kunci. Hasil penelitian ini menunjukkan bahwa terdapat berbagai potensi desa wisata yang dikelompokkan menjadi tiga antara lain potensi alam (Hutan Adat di Banjar Tiyingan, Persawahan, dan Perkebunan Organik, dan keindahan alam), potensi budaya (Situs Purbakala Sarkofagus, Tinggalan Arca di Pura Puseh Desa Bale Agung Bukian, Tradisi Bali Aga Ngasa Pura Dalem Bukian, Festival Budaya Bukian, dan Penglukatan Taman Megenda.), dan potensi buatan (air minum Gianyar, Sentra kerajinan kayu berupa jerapah dan kerajinan kayu lainnya, jalur Tracking dan Cycling.). Pengembangan ekowisata di Desa Bukian diharapkan memberikan manfaat yang optimal bagi masyarakat lokal, pelaku usaha dan pemerintah secara berkelanjutan serta berkontribusi secara finansial bagi pelestarian lingkungan.
FAKTOR-FAKTOR YANG MEMPENGARUHI KEPUTUSAN KONSUMEN MEMILIH BELANJA DI PASAR BADUNG
Authors: Wijayanthi Ida Ayu Trisna , Satam Fitra
Published: November 2022

Penelitian ini merupakan studi kasus pada Konsumen Pasar Badung di Kota Denpasar. Tujuan dari penelitian ini adalah untuk mengetahui: 1) faktor-faktor yang mempengaruhi keputusan konsumen dalam memilih Pasar Badung sebagai tempat berbelanja; 2) faktor apa yang paling dominan mempengaruhi keputusan konsumen dalam memilih Pasar Badung sebagai tempat berbelanja. Pengumpulan data diambil dari 100 responden dengan menyebarkan kuesioner. Teknik pengambilan sampel yang digunakan adalah model Purposive Convinience Sampling, dimana respondennya adalah orang-orang yang berbelanja di Pasar Badung. Teknik analisis data yang digunakan adalah Analisis Regresi Linier Berganda. Berdasarkan hasil penelitian dapat diketahui bahwa: secara simultan faktor budaya, faktor sosial, faktor pribadi dan faktor psikologis berpengaruh positif dan signifikan terhadap keputusan konsumen dalam memilih Pasar Badung sebagai tempat berbelanja. sedangkan secara parsial faktor budaya, faktor sosial dan faktor pribadi berpengaruh positif, sedangkan faktor psikologis berpengaruh negatif. Faktor yang paling dominan pengaruhnya adalah faktor budaya, karena memiliki nilai koefisien beta sebesar 0,959 dibandingkan dengan nilai koefisien faktor sosial (x2) sebesar 0,027, faktor pribadi (x3) sebesar 0,018, dan faktor psikologis (x4) sebesar 0,008.
ANALISIS PENGARUH PELATIHAN, INSENTIF DAN LINGKUNGAN KERJA TERHADAP KINERJA ATC (AIR TRAFFIC CONTROLLER) PADA PERUM LPPNPI CABANG YOGYAKARTA
Authors: Negara Nyoman Dicky Surya , Subarjo S.
Published: November 2022

Memahami pentingnya keberadaan sumber daya manusia di era global saat ini salah satu upaya yang harus dicapai oleh perusahaan adalah dengan meningkatkan kualitas kinerja sumber daya manusia. Oleh karena itu, penelitian ini bertujuan untuk mengetahui faktor – factor yang dapat mempengaruhi kinerja karyawan di Perum LPPNPI Cabang Yogyakarta. Faktor – faktor  tersebut yaitu Insentif, Pelatihan dan Lingkungan Kerja. Kinerja yang tinggi akan memberikan dampak positif bagi perusahaan / organisasi sehingga tujuan perusahaan dapattercapai. Pengujian hipotesis dilakukan dengan menyebar kuesioner kepada karyawan Perum LPPNPI Cabang Yogyakarta khususnya ATC. Berdasarkan hasil perhitungan data dan analisis yang digunakan, diperoleh persamaan regresi yaitu:

Y = 10,162 (α) + 0,537 X1+ 0,246 X2 + 0,593 X3

Berdasarkan analisis Uji Regresi Berganda yang dilakukan menunjukkan variabel pelatihan memiliki nilai t hitung sebesar 4,905 > t tabel 2,021 dan nilai signifikasi sebesar 0,000 < alpha 0,05. Hasil tersebut berarti bahwa Ho ditolak dan Ha diterima yang artinya variabel pelatihan berpengaruh signifikan terhadap kinerja karyawan. Berdasarkan analisis Uji Regresi Berganda yang dilakukan menunjukkan variabel insentif memiliki nilai t hitung sebesar 3,350 > t tabel 2,021 dan nilai signifikasi sebesar 0,002 < alpha 0,05. Hasil tersebut berarti bahwa Ho ditolak dan Ha diterima yang artinya variabel insentif berpengaruh signifikan terhadap kinerja karyawan. Berdasarkan analisis Uji Regresi Berganda yang dilakukan menunjukkan variabel lingkungan kerja memiliki nilai t hitung sebesar 2,463 > t tabel 2,021 dan nilai signifikasi sebesar 0,018 < alpha 0,05. Hasil tersebut berarti bahwa Ho ditolak dan Ha diterima yang artinya variabel lingkungan kerja berpengaruh signifikan terhadap kinerja karyawan.
DAMPAK PANDEMI COVID-19 PADA SEKTOR KULINER DI BALI
Authors: Mariani Wayan Eny , Anom I Gusti Ayu , Wijaya Bagus Kusuma
Published: November 2022

Seluruh dunia saat ini sedang menghadapi pandemi COVID-19 atau yang juga dikenal dengan nama virus Corona. Kasus positif terinfeksi virus corona kini telah menyebar di 223 negara. Indonesia adalah negara terpadat keempat di dunia dan diperkirakan akan terpengaruh secara signifikan dalam periode waktu yang lebih lama. Dampak dari pandemi ini tidak hanya pada dunia kesehatan, namun juga merambah hampir ke seluruh aspek kehidupan bermasyarakat di mana masyarakat dan perusahaan telah diimbau untuk melakukan pembatasan dalam beraktivitas. Imbauan ini mengakibatkan banyak perusahaan tidak lagi dapat beroperasi sebagaimana biasanya. Salah satu lapangan usaha yang terdampak pandemi adalah usaha yang bergerak di bidang kuliner. Penelitian ini bertujuan untuk melihat dampak pandemi Covid-19 terhadap UMKM khususnya yang bergerak di bidang kuliner di Provinsi Bali. Hasil dari penelitian ini menemukan bahwa pandemic COVID-19 mengakibatkan penurunan pertumbuhan produk domestic regional bruto di Bali.
AVALIAÇÃO DO AUTOCUIDADO ACERCA DOS FATORES DE RISCO PARA O CÂNCER DE PELE
Authors: Dall'Agnol Salva Caroline , Dexheimer Geórgia Muccillo
Published: November 2022

O câncer é a segunda causa de morte no país, sendo o câncer de pele a neoplasia mais incidente. É preciso ficar em alerta para os sintomas da doença e a importância do diagnóstico precoce. Por isso, é relevante estar informado sobre a doença pois, esta é a melhor maneira de preveni-la, diagnosticá-la e tratá-la. Alguns fatores de risco que contribuem para a gênese das lesões de pele, como fatores genéticos, história de câncer na família e radiação ultravioleta (UV) já estão comprovados. Objetivo: Avaliar os fatores de risco e autocuidado da população ao câncer de pele. Materiais e métodos: Foi realizado um questionário através da plataforma Google Forms com a população em geral, para que seja possível avaliar diferentes perfis como jovens e adultos, homens e mulheres, relacionando com os cuidados adotados em relação a fatores de risco associados ao câncer de pele, no período de Agosto de 2021. Resultados: Obteve-se um total de 259 respostas, onde 190 pessoas (73,4%) eram do sexo feminino. Ainda, a prevalência foi de pessoas jovens, com graduação e de cor branca e, a maioria das pessoas trabalha e estuda. Quanto às medidas e hábitos de fotoproteção na rotina diária, 222 (85,7%) participantes estão expostos aos raios ultravioleta. Em relação aos fatores de proteção solar, 145 (83,3%) dos indivíduos usam o fator UVA/UVB, e 104 (42,3%) não usam protetor solar. Conclusão: Observa-se que o autocuidado e o risco da exposição ao sol ainda é subestimado na população. Portanto, constantes campanhas educativas e informativas devem ser realizadas a fim de garantir uma educação permanente da população e promover a saúde, diminuindo assim as taxas de câncer de pele.
COMPARAÇÃO ENTRE A APTIDÃO FÍSICA DE PRATICANTES RECREACIONAIS DE CROSSFIT E TREINAMENTO DE FORÇA
Authors: Dullius Lucas Ariel , Tiggemann Carlos Leandro
Published: November 2022

Níveis elevados de aptidão física estão relacionados a diminuição de comorbidades e aumento da qualidade e expectativa de vida. Atualmente, diversas metodologias de treinamento que visam o aprimoramento da aptidão física, onde podemos destacar o CrossFit pelo forte apelo midiático e características motivacionais que lembram competições. Neste mesmo contexto, temos o treinamento de força tradicional, que é uma das formas mais populares de exercício para aprimoramento da aptidão física. Devido à grande importância da aptidão física possui em relação a saúde, é de grande importância identificar qual modalidade se sobressai em relação as demais neste contexto. O presente estudo tem como objetivo comparar o nível de aptidão física entre praticantes recreacionais de CrossFit e treinamento de força. A amostra foi composta por 14 homens, sendo 7 praticantes de CrossFit e 7 praticantes de treinamento de força, com no mínimo 1 ano de experiência. Os indivíduos foram avaliados em sua antropometria, força máxima, força resistente, potência, agilidade, flexibilidade e resistência cardiorrespiratória em diferentes protocolos indiretos. Nas variáveis de composição corporal, houve diferença significativa entre os grupos apenas na estatura (p=0,016), indicando que o grupo treinamento de força era mais alto. Já nos demais parâmetros de composição corporal e nos parâmetros de aptidão física, não houve nenhuma diferença significativa. Os achados do presente estudo sugerem que os praticantes de CrossFit apresentam desempenho semelhante aos praticantes de treinamento de força tradicional.
CONSUMO DE SUPLEMENTOS TERMOGÊNICOS POR PRATICANTES DE MUSCULAÇÃO DA SERRA GAÚCHA
Authors: Oliveira Cristiano Hanauer , Conde Simara Rufatto
Published: November 2022

A prática da musculação para a melhoria da composição corporal e busca de baixos percentuais de gordura incita à procura de maneiras para acelerar esse processo, através de substâncias que aumentam a temperatura corporal e otimizam a utilização de gordura como fonte de energia, os conhecidos suplementos termogênicos. O objetivo da pesquisa foi avaliar o consumo de suplementos termogênicos por praticantes de musculação da cidade de Caxias do Sul da Serra Gaúcha. O estudo é de caráter transversal quantitativo e foi realizado em três academias e duas lojas de suplementos. A amostra foi por conveniência e composta por 145 indivíduos de ambos os sexos que responderam a um formulário adaptado pelo pesquisador para coleta de dados sobre consumo de suplementos termogênicos. Com este estudo foi encontrado um percentual 62,75% da amostra (n=91) que utilizaram ou estão utilizando suplementos termogênicos, e desse total 51,79% (n=59) afirmaram que o uso foi indicação de coach, vendedor de loja de suplemento ou auto prescrição, seguido de 48,7% (n=56) que tiveram prescrição de um profissional de saúde habilitado. Não houve diferença em relação aos sexos sobre o consumo ou não de suplementos termogênicos (p=0,2980), os indivíduos do sexo masculino demonstraram um consumo semanal significativamente maior em relação as mulheres (p=0,0491). As mulheres buscaram de forma significativamente maior de indicação de ST por profissionais habilitados, bem como, maior realização de exames periódicos de saúde ao menos uma vez por ano quando comparado aos homens (p
ESTADO NUTRICIONAL, CONSUMO ALIMENTAR E NÍVEL DE ATIVIDADE FÍSICA EM IDOSOS FREQUENTADORES DE UMA ACADEMIA
Authors: Lupato Eduarda Spolti , Conde Simara Rufatto
Published: November 2022

São considerados idosos, indivíduos com idade igual ou superior a 60 anos segundo a Organização Mundial da Saúde (2015). Estes fazem parte de um grupo de risco nutricional devido às mudanças fisiológicas do envelhecimento, podendo afetar tanto o consumo alimentar quanto a necessidade de nutrientes, sendo necessário a combinação da qualidade e quantidade dos alimentos juntamente com a prática de exercícios físicos. Assim, se torna possível alcançar a terceira idade com melhor qualidade de vida, se priorizar uma alimentação nutritiva adequada, com prática de atividades físicas, de lazer e socialização (SILVA et al., 2020). Objetivo: associar o estado nutricional e o consumo alimentar com o nível de atividade física em idosos frequentadores de uma academia. Método: pesquisa de caráter transversal quantitativo realizado com 12 idosos de ambos os sexos, frequentadores de uma academia do Vale do Taquari. Foi avaliado o estado nutricional do idoso, através do índice de massa corporal (IMC), circunferências da cintura (CC), quadril (CQ), panturrilha (CP) e do braço (CB) e foram classificados de acordo com a Organização Pan-americana de Saúde (OPAS 2002) a Organização Mundial da Saúde (OMS 1998), Chumlea e Cols(1995) e Blackburn e Thorton (1979). O consumo alimentar foi avaliado através do diário alimentar de 3 dias, sendo realizada a média aritmética dos 3 dias, foram calculados pelo software DietSmart analisados os macronutrientes: carboidratos, proteínas, lipídios e fibras e os micronutrientes: vitamina A, B12, C, D e E, e os minerais cálcio, ferro e zinco estes foram comparados com as recomendações da Dietary Reference Intakes (DRI, 2019). O nível de atividade física foi avaliada por meio de um questionário Internacional de atividade física-IPAQ (MAZO; BENEDETTI, 2010). Resultados: A idade média foi de 65,3±5,3 anos, 50% (n=6) da amostra estava em eutrofia entre os idosos a maioria não possuía risco cardiovascular 83,3% (n=10), na classificação da CP 100% (n=12) da amostra estava adequado. Quanto ao nível de atividade física 33,3% (n=4) foram classificados como ativos. No consumo alimentar, 100% (n=12) tiveram o consumo adequado de proteínas, e inadequado em cálcio e vitamina D. Quando comparado o consumo alimentar com o sexo constatou-se que indivíduos masculinos apresentaram um consumo de vitamina C significativamente acima do recomendado quando comparado com mulheres (p=0,002). Conclusão: A maioria dos idosos estava em eutrofia e tiveram o consumo alimentar adequado de proteínas, inadequado de vitamina D e cálcio e apresentaram o nível de atividade física porcentagem igualmente distribuída para ativo, muito ativo e insuficientemente ativo.
DESAFIOS E ALCANCES DO TRABALHO DO PSICÓLOGO HOSPITALAR NA PANDEMIA DE COVID-19: UMA REVISÃO DE LITERATURA
Authors: Teixeira Júlia De Medeiros
Published: November 2022

Este estudo teve como objetivo compreender os desafios e os alcances da atuação do psicólogo no contexto hospitalar durante a pandemia de COVID-19. A pesquisa foi realizada através de uma revisão bibliográfica de caráter qualitativo, sobre o assunto num período de três meses nas seguintes bases de dados eletrônicas: Scielo, Google Acadêmico, PePSIC, Lilacs. Pelos resultados obtidos, constatou-se que a pandemia prejudicou a escuta e observação, principais instrumentos de trabalho do psicólogo, potencializou o sofrimento referente ao processo de adoecimento e hospitalização tanto para os pacientes, quanto familiares, além de afetar a equipe de saúde em razão ao grande volume de trabalho. Portanto, o psicólogo teve que manejar as dificuldades impostas e encontrar alcances possíveis como: uso de tecnologia para atendimentos, promoção de um espaço acolhedor, estratégias de cuidado, atendimentos psicológicos online, orientações e intervenções para manutenção da saúde mental.
Anti-nerve cancer effects of the Ag nanoparticles green-mediated by Scrophularia striata aqueous extract
Authors: Guo Jun
Published: November 2022

In the present study, we tried to prepare and formulate a
chemotherapeutic drug (Silver nanoparticles in aqueous medium using
Scrophularia striata leaf extract) for the treatment of nerve cancer.
The chemical characterization tests including UV–Visible Spectroscopy
(UV-Vis), Fourier Transformed Infrared Spectroscopy (FT‐IR), and Field
Emission Scanning Electron Microscopy (FE‐SEM) were used for the
characterization of silver nanoparticles. To survey the cytotoxicity and
anti-nerve cancer effects of AgNO3, S. striata aqueous extract, and
AgNPs, MTT assay was used on the nerve (Human peripheral nerve sheath
tumor (S462 and BL1391)) cancer cell lines. For investigating the
antioxidant properties of AgNO3, S. striata aqueous extract, and AgNPs,
the DPPH test was used in the presence of butylated hydroxytoluene as
the positive control. In the FE-SEM images, the silver nanoparticles
were in an average size of 36.19 nm with the spherical shape. The
results of MTT assay confirmed removing the S462 and BL1391 cell lines
after treating with low concentrations of AgNPs. AgNPs inhibited half of
the DPPH molecules in the concentration of 97 µg/mL. As mentioned, AgNPs
had significant anti-nerve cancer properties against the above cell
lines.
The long-term outcomes of catheter ablation for atrial fibrillation in heart failure with preserved ejection fraction
Authors: Niu Guodong , Qiao Yu , Zhao Zhen , Cai Xiang , Guo Yulong , Fu Mingpeng , Liu Ke , Guo Jinrui , Guo Tao
Published: November 2022

Background We aimed to compare the long-term outcomes of
catheter ablation and medical treatment in patients with atrial
fibrillation (AF) and heart failure with preserved ejection fraction
(HFpEF). Methods We retrospectively screened consecutive
patients with AF and HFpEF who received catheter ablation or medical
treatment from December 2017 to June 2021 in our institution. The
primary endpoint was defined as a composite of all-cause death,
thromboembolic events and heart failure (HF) hospitalization.
Multivariate analysis, 1:1 propensity score matching (PSM) and inverse
probability of treatment weighting (IPTW) were employed to adjust for
potential confounders. Results A total of 131 patients were
included, among whom 71 patients (54.2%) underwent 1.15 + 0.36 catheter
ablation procedures. During a median follow-up of 31.8 months, the
incidence of the primary endpoint was significantly lower in catheter
ablation group (9.9% vs 25.0%, log rank p = 0.018) compared with
medical treatment group. In the multivariate model, catheter ablation
was independently associated with a lower incidence of the primary
endpoint (hazard ratio 0.281, 95% confidence interval 0.110 – 0.721, p
= 0.008), which was consistent both in PSM and IPTW cohorts. The New
York Heart Association class [2 (1, 2) vs 2 (2, 2), paired p
< 0.001], N-terminal pro-B type natriuretic peptide level
[334.3 (187.1, 821.8) vs 859.2 (308.4, 1903.0), paired p <
0.001] and left atrial diameter (39.4 + 6.4 vs 41.1 + 6.2, paired p =
0.001) were significantly improved at the end of follow-up in catheter
ablation group. Conclusion Catheter ablation was significantly
associated with a lower incidence of the composite endpoint, improved HF
symptoms and reverse atrial remodeling in AF and concomitant HFpEF.
Comparative genomic analysis and constraint-based analysis of genome-scale metabolic models of the genus Clostridia
Authors: Moholkar Vijayanand S. , Kumar Karan , Barbora Lepakshi
Published: November 2022

In recent years, bacteria from genus Clostridia have attracted
attention of research community because of their biofuel production
capabilities. Present study reports comparative genomic (CG) analysis of
48 genomes of solventogenic and saccharolytic Clostridia. We have
focused on central carbon metabolism and general stress response in the
analysis. Comprehensive summaries on comparison of general genome
features, COG categories, CDSs of the energy, catabolic, and sporulation
pathways are given. Furthermore, we have proposed two new genome-scale
metabolic (GSM) models iKK848 and iKK1425 for
Clostridium pasteurianum DSM 525 = ATCC 6013 and
Clostridium acetobutylicum ATCC 824, respectively. These GSM
models are most comprehensive in that they account for the largest
number of reactions, metabolites, and genes as compared to previous
models. Model quality and metabolic flux optimization for biomass growth
using iKK1425 and iKK848 are compared with previous
literature. Our models had the highest quality score of 61% and 77%.
Genetic responses in sexual diploid and asexual triploid goldfish (Carassius auratus) introduced into a high-altitude environment
Authors: Feng Xiu , Liu Shenglin , Sui Xiaoyun , Chen Yifeng , Zhu Ren , Jia Yintao , Tong Jingou , Yu Xiaomu , Liu Chunlong , Hansen Michael
Published: November 2022

Anthropogenic biological invasions represent major concerns but enable
us to investigate rapid evolutionary changes and adaptation to novel
environments. The goldfish Carassius auratus with sexual diploids and
asexual triploids coexisting in natural waters, is one of the most
widespread invasive fishes in Tibet, providing an ideal model to study
evolutionary processes during invasion in different reproductive forms
from the same vertebrate. Here, using whole-genome resequencing data of
151 C. auratus individuals from invasive and native ranges, we found
different patterns of genomic responses between diploid and triploid
populations during their invasion to Tibet. For diploids, although
invasive individuals derived from two different genetically distinct
sources and had a relative higher diversity (π) at the population level,
their individual genetic diversity (genome-wide observed heterozygosity)
was significantly lower (21.4%) than that of source individuals.
Population structure analysis revealed that the invasive individuals
formed a specific genetic cluster distinct from the source populations.
Runs of homozygosity analysis showed low inbreeding only in invasive
individuals, and only the invasive population experienced a recent
decline in effective population size reflecting founder events. For
triploids, however, invasive populations showed no loss of individual
genetic diversity and no genetic differentiation relative to source
populations. Regions of putative selective sweeps between invasive and
source populations of diploids mainly involved genes associated with
mannosidase activity and embryo development. Our results suggest
invasive diploids deriving from distinct sources still lost individual
genetic diversity resulting from recent inbreeding and founder events
and selective sweeps, and invasive triploids experienced no genetic
change owing to their reproduction mode of gynogenesis that precludes
inbreeding and founder effects and may make them more powerful invaders.
Safety and effectiveness of Chloral Hydrate in Auditory Brainstem Response tests: a single-center and cross-sectional study
Authors: Zhang Xiangling , Liu Haotian , Yao Xinyi , Liu Min , Jin Youyou , Zheng Yun , Zhang Wei , Meng Zhaoli , Zhao Yu
Published: November 2022

Objective: Chloral Hydrate is the most commonly used sedative for
Auditory Brainstem Response (ABR) test. The aim of this study was to
retrospectively analyze the safety and effectiveness of Chloral Hydrate
in patients undergoing ABR tests through a single-center and large
sample size cross-sectional study. Methods: Data were collected from
December 2015 to March 2022, which included 7,176 ABR tests (6,106
patients). Basic information was collected, then telephone follow-up was
conducted for patients with two or more consecutive tests less than 60
days, and administration method, failure performance, and adverse events
were collected. Total sedation failure rate, sedation failure rates in
different age groups (≤0.5 years, 0.5-3 years, 3-12 years, ≥12 years)
and incidence of adverse events were calculated. Results: A total of
4,967(69.21%) ABR tests were younger than 3 years of age. The sedation
failure rate was 3.11% with a Chloral Hydrate dose of 30 mg/kg of
weight, which ranged from 1.44% to 4.31% in different age groups. In
the sedation failure tests, insufficient sedation was found in 74.44%
of the tests. The incidence of adverse events was 0.35%, with most
commonly vomiting. Conclusion: The sedation failure rate and the
incidence of adverse events in this study are relatively low compared
with other previous studies, and Chloral Hydrate can be considered a
safe and effective sedative with the permissible dose. However, there
were still many patients who failed to complete the test due to
insufficient sedation (mostly infants and children), which imply that
alternative sedatives with easier preparation process are needed.
Updating the dual C and O isotope – gas exchange model: A concept to understand plant responses to the environment and its implications for tree rings
Authors: Siegwolf Rolf , Lehmann Marco , Goldsmith Gregory , (Sidorova) Olga Churakova , Mirande-Ney Cathleen , Timofeeva Galina , Weigt Rosemarie , Saurer Matthias
Published: November 2022

The combined study of C and O isotopes in plant organic matter has
emerged as a powerful tool for understanding plant functional responses
to environmental change. The approach relies on established
relationships between leaf gas exchange and isotopic fractionation to
derive a series of model scenarios that can be used to infer changes in
photosynthetic assimilation and stomatal conductance driven by changes
in environmental parameters (CO2, water availability, air humid-ity,
temperature, nutrients). We review the mechanistic basis for a
conceptual model, in light of recently published research, and discuss
where isotopic observations don’t match our current understanding of
plant physiological response to environment. We demonstrate that 1) the
mod-el was applied successfully in many, but not all studies, 2), while
originally conceived for leaf isotopes, the model has been applied
extensively to tree ring isotopes in the context of tree physiology and
dendrochronology. Where isotopic observations deviate from
physiologically plau-sible conclusions, this mismatch between
gas-exchange and isotope response provides valuable insights on
underlying physiological processes. Overall, we found that isotope
responses can be grouped into situations of increasing resource
limitation versus higher resource availability. The dual isotope model
helps to interpret plant responses to a multitude of environmental
factors.
Efficacy of Constructivist’s Teaching Method in Proving Mensuration Theorem: Implications for Nigeria Senior Secondary School Students
Authors: Unodiaku Stanislus Sochima
Published: November 2022

The study was conducted to determine the efficacy of the constructivist’s teaching method (CTM) on teaching proof of mensuration theorem: a panacea for senior secondary school students’ interest and achievement. The population of the subjects was 3095 SSS II students composed of students in secondary schools in the Agbani Education zone of Enugu State. Four research questions and four null hypotheses guided the study. Multi-stage sampling technique was used for the study, based on which 197 students composed of 95 males and 102 females were randomly sampled. Data was collected using Mathematics Achievement Test (MAT) and Mathematics Interest Inventory Test (MIIT). The Cronbach alpha statistic and test-retest methods were used in determining the reliability estimates of the MAT and MIIT respectively which yielded 0.89 and 0.91 respectively. The data obtained with the instruments were analyzed with descriptive statistics (mean and standard deviation) in answering the research questions. The findings of the study clearly showed that CTM is effective in enhancing students’ achievement and interest in mathematics learning, especially in proving mensuration theorems. Those exposed to the treatment performed significantly higher than those exposed to the expository method after the treatment. Moreso, those in the experimental group showed a significant difference in mean interest rating in Mathematics than those in the control group after the treatment (post-test). These recorded significant mean differences in achievement and interest of the students after they were exposed to the treatment showing that CTM is responsible for such enhanced increase in performance of the students and their interest. The observed no significant mean difference in performance and interest between male and female subjects shows that CTM is capable of bridging the existing gap in performance and interest in mathematics between males and females.
Prevalence and severity of TMD in orthodontic patients
Authors: Zivkovic Marija , Milenkovic Masa , Amanovic Milana , Simic Ana , Stratimirovic Djordje
Published: November 2022

Introduction. Temporomandibular disorder (TMD) is a collective term for
numerous symptoms, with the most common being masticatory muscle pain, pain
in temporomandibular joints, limited mouth opening, irregular jaw movements,
headaches and sound effects in TMJ. The aim was to determine the prevalence
and severity of TMD in orthodontic patients determining whether the type of
malocclusion affects the prevalence and severity of TMD. Material and
Methods. The study was conducted in the form of Fonseca Anamnestic Index,
which classifies TMD severity among examinees (no TMD, mild, moderate and
severe TMD). The experimental group consisted of orthodontic patients with
confirmed malocclusions, while the control group consisted of dental
students with a Class I occlusion and no need for orthodontic treatment.
Orthodontic patients were classified into the three subgroups based on
malocclusions. Results. In the experimental group, 45.03% of orthodontic
patients had some degree of TMD, while among students, that percentage was
56.41%. Compared to Class I, higher percentage of TMD was found among
patients with distal and mesial occlusion in experimental group. In the
experimental and control groups, the greatest percentage of participants
showed mild TMD. The prevalence of TMD was greater in females than in males
in the experimental group. Conclusion. The high prevalence of TMD in the
control group speaks in favor of its complex etiology, with stress having an
important role. Malocclusion is one of many factors which can contribute to
the occurrence and severity of TMD, but it cannot be considered the most
significant.
Cost-Effectiveness of a Collaborative Care Model Among Patients With Type 2 Diabetes and Depression in India
Authors: Emmert-Fees Karl M.F. , Laxy Michael , Patel Shivani A. , Singh Kavita , Poongothai Subramani , Mohan Viswanathan , Chwastiak Lydia , Narayan K.M. Venkat , Sagar Rajesh , Sosale Aravind R. , Anjana Ranjit Mohan , Sridhar Gumpeny R. , Tandon Nikhil , Ali Mohammed K.
Published: November 2022

OBJECTIVE

To assess the cost-effectiveness of collaborative versus usual care in adults with poorly controlled type 2 diabetes and depression in India.

RESEARCH DESIGN AND METHODS

We performed a within-trial cost-effectiveness analysis of a 24-month parallel, open-label, pragmatic randomized clinical trial at four urban clinics in India from multipayer and societal perspectives. The trial randomly assigned 404 patients with poorly controlled type 2 diabetes (HbA1c ≥8.0%, systolic blood pressure ≥140 mmHg, or LDL cholesterol ≥130 mg/dL) and depressive symptoms (9-item Patient Health Questionnaire score ≥10) to collaborative care (support from nonphysician care coordinators, electronic registers, and specialist-supported case review) for 12 months, followed by 12 months of usual care or 24 months of usual care. We calculated incremental cost-effectiveness ratios (ICERs) in Indian rupees (INR) and international dollars (Int’l-$) and the probability of cost-effectiveness using quality-adjusted life-years (QALYs) and depression-free days (DFDs).

RESULTS

From a multipayer perspective, collaborative care costed an additional INR309,558 (Int’l-$15,344) per QALY and an additional INR290.2 (Int’l-$14.4) per DFD gained compared with usual care. The probability of cost-effectiveness was 56.4% using a willingness to pay of INR336,000 (Int’l-$16,654) per QALY (approximately three times per-capita gross domestic product). The willingness to pay per DFD to achieve a probability of cost-effectiveness >95% was INR401.6 (Int’l-$19.9). From a societal perspective, cost-effectiveness was marginally lower. In sensitivity analyses, integrating collaborative care in clinical workflows reduced incremental costs by ∼47% (ICER 162,689 per QALY, cost-effectiveness probability 89.4%), but cost-effectiveness decreased when adjusting for baseline values.

CONCLUSIONS

Collaborative care for patients with type 2 diabetes and depression in urban India can be cost-effective, especially when integrated in clinical workflows. Long-term cost-effectiveness might be more favorable. Scalability across lower- and middle-income country settings depends on heterogeneous contextual factors.
Development of a Clinical Prediction Model for Diabetes in Chronic Pancreatitis: The PREDICT3c Study
Authors: Jeon Christie , Hart Phil A. , Li Liang , Yang Yunlong , Chang Eleanor , Bellin Melena D. , Fisher William E. , Fogel Evan L. , Forsmark Christopher E. , Park Walter G. , Van Den Eeden Stephen K. , Vege Santhi Swaroop , Serrano Jose , Whitcomb David C. , Andersen Dana K. , Conwell Darwin L. , Yadav Dhiraj , Goodarzi Mark O.
Published: November 2022

OBJECTIVE

Diabetes that arises from chronic pancreatitis (CP) is associated with increased morbidity and mortality. Methods to predict which patients with CP are at greatest risk for diabetes are urgently needed. We aimed to examine independent risk factors for diabetes in a large cohort of patients with CP.

RESEARCH DESIGN AND METHODS

This cross-sectional study comprised 645 individuals with CP enrolled in the PROCEED study, of whom 276 had diabetes. We conducted univariable and multivariable regression analyses of potential risk factors for diabetes. Model performance was assessed by area under the receiver operating characteristic curve (AUROC) analysis, and accuracy was evaluated by cross validation. Exploratory analyses were stratified according to the timing of development of diabetes relative to the diagnosis of pancreatitis.

RESULTS

Independent correlates of diabetes in CP included risk factors for type 2 diabetes (older age, overweight/obese status, male sex, non-White race, tobacco use) as well as pancreatic disease–related factors (history of acute pancreatitis complications, nonalcoholic etiology of CP, exocrine pancreatic dysfunction, pancreatic calcification, pancreatic atrophy) (AUROC 0.745). Type 2 diabetes risk factors were predominant for diabetes occurring before pancreatitis, and pancreatic disease–related factors were predominant for diabetes occurring after pancreatitis.

CONCLUSIONS

Multiple factors are associated with diabetes in CP, including canonical risk factors for type 2 diabetes and features associated with pancreatitis severity. This study lays the groundwork for the future development of models integrating clinical and nonclinical data to identify patients with CP at risk for diabetes and identifies modifiable risk factors (obesity, smoking) on which to focus for diabetes prevention.
Questionnaire-based polyexposure assessment outperforms polygenic scores for classification of type 2 diabetes in a multi-ancestry cohort
Authors: Akhtari Farida S. , Lloyd Dillon , Burkholder Adam , Tong Xiaoran , S. House John , Lee Eunice Y. , Buse John , Schurman Shepherd H. , Fargo David C. , Schmitt Charles P. , Hall Janet , Motsinger-Reif Alison A.
Published: November 2022

 

  

Objective. Environmental exposures may have greater predictive power for type 2 diabetes than polygenic scores (PGS). Studies examining environmental risk factors, however, have included only individuals with European ancestry, limiting the applicability of results. We conducted an exposome-wide association study in the multi-ancestry Personalized Environment and Genes Study to assess the effects of environmental factors on type 2 diabetes. 

Research Design and Methods. Using logistic regression for single-exposure analysis, we identified exposures associated with type 2 diabetes, adjusting for age, body mass index (BMI), household income, and self-reported sex and race. To compare cumulative genetic and environmental effects, we computed an overall clinical score (OCS) as a weighted sum of BMI and prediabetes, hypertension, and high cholesterol and a polyexposure score (PXS) as a weighted sum of 13 environmental variables. Using UK Biobank data, we developed a multi-ancestry PGS and calculated it for participants. 

Results. We found 76 significant associations with type 2 diabetes, including novel associations of asbestos and coal dust exposure. OCS, PXS, and PGS were significantly associated with type 2 diabetes. PXS had moderate power to determine associations, with larger effect size and greater power and reclassification improvement than PGS. For all scores, the results differed by race. 

Conclusions. Our findings in a multi-ancestry cohort elucidate how type 2 diabetes odds can be attributed to clinical, genetic, and environmental factors and emphasize the need for exposome data in disease-risk association studies. Race-based differences in predictive scores highlight the need for genetic and exposome-wide studies in diverse populations. 
Pengembangan E-book Berbasis Problem Based Learning pada Materi Perubahan Lingkungan dan Daur Ulang Limbah untuk Siswa di MAN Karangasem
Authors: Maulida Sabrina Intan , Adnyana Putu Budi , Bestari Ida Ayu Purnama
Published: November 2022

This research aims to find out the design, validity, and practicality of e-books based on problem-based learning as a teaching material for environmental change and waste recycling for grade X at MAN Karangasem. This type of research is research & development (R&D) using a 4-D development model which is modified into three stages, namely define, design, and develop. After the e-book was developed, then an assessment was carried out with validity tests by material experts and media experts and practicality tests by testing 3 students in grade X IPA 3 in an individual test, and 9 students from grade X IPA 3 in a small group test. The location of this research is at MAN Karangasem. The data obtained will be analyzed descriptively to determine the validity and practicality of PBL-based e-books. The results of this study indicate, (1) e-books based on PBL are designed in an attractive manner where the content of the material is adapted to PBL syntax, consisting of 3 sub-chapters, in each sub-chapter there are several interactive features and in accordance with the PBL syntax. PBL such as Bio-Earth News, Bio Let's Thinking, Bio MiniLab&Activyty, Bio Anova, Bio Best Info and Bio Funzone, (2) the validity of e-books based on PBL is 91.9% which is included in the very feasible criteria, and (3) the practicality of e-books based on PBL of 90.5% are included in the very practical criteria. From the results of this study, it was concluded that the e-books based on PBL that was developed was very feasible and very practical as a teaching material on environmental change and waste recycling materials for grade X at MAN Karangasem.
Globalization and New Education Frontiers: A Look at the Factors Affecting Virtual Learning in Kenya
Authors: Smith Christine
Published: November 2022

The advent of globalization has brought with it a drastic change in the education sector in Kenya. The flexibility of new learning environments is an interesting aspect that is now commonplace in learning institutions. The interaction of people across the globe brings about a merging of cultures, experiences, skills, and expertise. In addition, the global market presents learning institutions with a wide student base that are willing to enroll in their educational programs. Education has now evolved from the traditional classroom blackboard approach into a more technological advanced platform. This platform is commonly referred to as Virtual learning and is widely used by many universities across the world. The article indicates that there are difficulties that face this form of education in developing countries, specifically Kenya, making it a farfetched development goal in the Kenyan educational institution. The study collected primary data and used regression analysis to analyze data. The findings presented in the article cite technology, internet connectivity, low investment, and teaching practices as critical factors affecting Virtual learning in Kenya.
Aumento de tecido queratinizado ao redor de dentes e implantes através do enxerto gengival livre
Authors: Mizutani Fábio Shiniti , de Freitas Atila , Nastri Victor Hugo Taddeo , Wood Patrícia Fretes
Published: November 2022

O objetivo deste artigo foi relatar procedimento de aumento de tecido queratinizado ao redor de dentes e implantes. A finalidade de aumentar a faixa queratinizada nos dentes foi impedir o avanço da recessão gengival, assim como diminuir a sensibilidade durante a escovação. O objetivo do enxerto gengival na região de implante foi promover um ambiente biológico mais protetivo quanto ao acometimento de mucosites. O manejo dos tecidos moles foi realizado através da técnica do enxerto gengival livre, que consta de preparo do sítio receptor através da realização de um retalho de espessura parcial que garante nutrição e revascularização do enxerto, que foi removido do palato obedecendo um formato obtido através de gabarito cirúrgico. A cicatrização ocorreu dentro da boa previsibilidade que a técnica apresenta, atingindo os objetivos clínicos primários. Podemos afirmar que o procedimento de enxerto gengival livre resulta em benefícios biológicos de ganho de tecido queratinizado, proporcionando prevenção à evolução das recessões gengivais em áreas dentadas, e o desenvolvimento de mucosites ao redor de implantes.
Carimbo oclusal e resina bulk-fill em restauração direta de dentes posteriores – relato de caso
Authors: Araújo Patrícia Ferronato , Mancia Brenda Lisseth Pineda , Sakamoto Junior Antonio Setsuo
Published: November 2022

As restaurações de dentes posteriores pela técnica incremental geralmente tomam mais tempo do cirurgião- -dentista. Além de existir a possibilidade de ocorrência de bolhas entre as camadas, é necessária uma boa execução das cristas, cúspides, sulcos, fóssulas e fissuras para que a anatomia não seja removida na fase de ajuste oclusal. O objetivo deste artigo foi apresentar uma alternativa clínica, para agilizar e otimizar a restauração de dentes posteriores, através de um relato de caso de uma paciente com lesões de cárie dental em 3 dentes adjacentes. Como estes apresentavam a anatomia oclusal majoritariamente intacta, foi realizada uma cópia prévia da face oclusal e confeccionado um carimbo oclusal de cada elemento, técnica conhecida como “Stamp Technique”. O uso da técnica do carimbo oclusal associada à utilização de resina bulk-fill termoviscosa como material restaurador facilita a obtenção da anatomia pré-existente, reduz o tempo de trabalho clínico, além de agilizar a etapa de ajuste oclusal. É um procedimento customizado, barato e fácil para reconstrução anatomia de maneira fidedigna. Este relato de caso demonstra uma alternativa para tratamento restaurador de dentes posteriores, utilizando resina bulk-fill e técnica do carimbo oclusal para restauração de 3 elementos posteriores oferecendo agilidade clínica e excelente resultado funcional e estético.