bluuebunny/crossref_metadata_2025 huggingface dataset:
Unveiling Potential Therapeutic Targets for Breast Cancer Recurrence: Differentially Expressed Genes and Pathways in Post-Surgery Patients
Authors: Hamad Hamad Ali , Saeed Hammad Khalaf , Hussein Talib Hammad , Hussain Abdalwahab Bdewi , Hashim Nur Fariesha
Published: September 2024

Various intrinsic and extrinsic factors, including genetic changes and environmental factors, have been reported to contribute to tumor recurrence. However, insufficient information about the significantly dysregulated genes and pathways responsible for cancer recurrence, even after surgical removal of tumors and chemotherapy. The aim of this research is to find out the fundamental genes linked with progression of cancer that may play a critical role in breast cancer recurrence. To achieve this, a microarray dataset of Affymetrix Human Genome U133 Plus 2.0 Array platform was used to identify downregulated and upregulated genes that associated with tumor recurrence in post-surgery patients. The study includes 20 specimen, 10 samples extracted at the time of diagnosis and 10 samples taken 30 minutes post-surgery and chemotherapy. Genes that stand out from the rest in their level of expression were further subjected to subsequent functional enrichment analysis and hub genes identification to pinpoint the key genes associated with recurrence. Results revealed that significantly overexpressed genes were found to be enriched in cancer progression-associated signaling pathways, for example, Wnt pathway and proteoglycans in cancer. Moreover, the identified key hub genes (COL1A1, IGF1, COL1A2, DCN, LUM, MMP2, JUN, CXCL12, THBS2, and LOX) majorly found to play a role in gene expression regulation, dysregulated immune system, epithelial-to-mesenchymal transition, and extracellular matrix remodeling thus promoting the development of cancer and increasing the chances of recurrence after surgery and chemotherapy. The findings have uncovered key therapeutic targets associated with tumor recurrence through potential ECM-related genes whose overexpression may significantly contribute to tumorigenesis in breast cancer survivors by epithelial-to-mesenchymal transition and targeting them may improve the chances of better survival breast cancer patients and increase the quality of life by reducing the chances of recurrence. However, the study is solely bioinformatics-based; therefore, future study will be experimental validations to bring forth these key genes as potential therapeutic targets.
Rompimiento de la dormancia en ñame espino (Dioscorea rotundata [Poir.]) mediante la aplicación de reguladores de crecimiento vegetal
Authors: Serpa-Ortega Amir-José , Espinosa-Carvajal Manuel-Ramón , Sánchez-López Diana-Beatriz
Published: September 2024

La dormancia en los tubérculos de ñame espino (Dioscorea rotundata [Poir.]) presenta retos durante el almacenamiento y la siembra en campo debido a períodos prolongados de dormancia, lo que conduce a ataques fúngicos y una densidad de siembra reducida. Este estudio tuvo como objetivo explorar la eficacia de los reguladores de crecimiento vegetal (RCV) en inducir la brotación temprana en tubérculos comerciales de ñame espino para mitigar estos problemas. Los tubérculos se dividieron en secciones apicales, medias y basales, se trataron con diversos RCV y se sembraron en sustrato estéril. La tiourea a 1,0 g L-1 se destacó como el tratamiento más efectivo, promoviendo el mayor porcentaje de brotación en todos los períodos de observación. La tiourea a 2,0 g L-1 demostró ser eficaz para las secciones apicales y medias, mientras que el cloruro de mepiquat a 2,0 mL L-1 estimuló la brotación en la parte basal. Estos hallazgos demuestran el potencial de los RCV en inducir la brotación temprana y mejorar la uniformidad de la germinación en los tubérculos de ñame espino, ofreciendo implicaciones prácticas para una mejor gestión de los cultivos.
Students’ Conceptualisations of “Peace” and “War” in Drawing–Text Combinations: A Metapragmatic Multimodal Analysis
Authors: Blasch Lisa , Thoma Nadja
Published: September 2024

In this article, we investigate (partly guided) conceptualisations of “peace” (and “war”) in children’s school drawings and their accompanying textual framings. We draw on a transdisciplinary framework grounded in ethnography and metapragmatics, combining tools from socio‐pragmatic (critical) approaches to multimodal discourse. Our data consists of authentically generated, photographed image‐text worksheets that were publicly displayed on the fence of a primary school in a small town in Northern Italy in April 2022. Combining qualitative and quantitative analytical procedures, the (textual and multimodal) conceptualisations range from peace as a very concrete mode of secure‐relaxed experience of basic relationships, of home and togetherness, and of self, to peace as care and unity on a more (global‐)political scale. Contrary to ideologies on children’s drawings as naïve‐unmediated “windows” to inner states, our analysis shows how the trans‐/locally re‐/produced repertoire(s) of multimodal frozen mediated actions (including emblematic patterns such as emojis, peace‐flags, comics‐speech bubbles, etc.) are deployed ranging from realistic scenes to abstract and complex visual designs. Thereby, children show themselves as literate and often humorous‐creative practitioners of visual communication.
CUIDADOS DE ENFERMAGEM PARA PESSOA IDOSA ACOMETIDA POR COVID-19 ATENDIDA NA ATENÇÃO BÁSICA
Authors: SOUZA WELLYSON , De Lima Alves Karoline , Dalle Piagge Carmem Silvia Laureano , Silva Paredes Moreira Maria Adelaide , Costa Ferreira Thalys Maynnard , Oliveira Silva Antonia Lêda
Published: September 2024

Objetivo: Conhecer as evidências cientificas sobre os cuidados de enfermagem à pessoa idosa acometida por Covid-19 atendida na atenção básica de saúde. Métodos: Trata-se de uma revisão de escopo.Visando conferir o critério metodológico, foram acessadas às seguintes bases de dados e biblioteca: National Library of Medicine (Pubmed); Web of Science (WOS); Scopus; The Cochrane Library (Cochrane); Biblioteca Virtual de Saúde (BVS). Ao final, foram incluídos 13 artigos. Resultados:Verificou-se que, 61,5% (n=8) dos artigos foram publicados no ano de 2021. Quanto às bases de dados, 30,7% (n=4) foram indexados na PubMed. Ao delineamento, 23,0% (n=3) possuíram como delineamento metodológico estudo de caso.  84,6% (n=11) dos estudos possuíram como alvo de pesquisa a utilização de instrumentos desenvolvidos para a implementação de cuidados voltados à pessoa idosa. Conclusões: Percebeu-se os cuidados de enfermagem à pessoa idosa acometida por Covid-19 atendida na atenção básica de saúde, mostrando-se alcançado, tendo em vista a explanação amplamente acurada no que concerne aos cuidados descritos na literatura científica.
Geometry and topology of the projective plane
Authors:   Taras Shevchenko National University of Kyiv, Kyiv, Ukraine, Prishlyak Oleksandr , Bilun Svitlana ,   Taras Shevchenko National University of Kyiv, Kyiv, Ukraine
Published: September 2024

The topological structure and geometric properties of the projective plane are described, as well as its group of movements that generate projective transformations of the Euclidean plane.
Prosecutor’s Supervision over the Implementation of Legislation in the field Development of the Arctic Zone of the Russian Federation
Authors: Zinoviev I. L.
Published: September 2024

In the article, the author examines the Arctic territories supervised by the prosecutor’s office, where prosecutors supervise the implementation of laws in the development of the Russian Arctic. Highlights the main elements of prosecutorial supervision: subject, objects, subjects and powers of prosecutors. Analyzes the results of the work of regional prosecutors’ offices to supervise the implementation of laws, the supervised territory of which is entirely included in the Arctic zone of the Russian Federation. The author proposes in supervisory activities to take into account the main goals, objectives and priority areas of activity defined by the Fundamentals of State Policy of the Russian Federation in the Arctic for the period until 2035, as well as the Strategy for the Development of the Arctic Zone of the Russian Federation and Ensuring National Security for the period until 2035. In order to improve prosecutorial supervision, the author proposes to create a new structural unit in the Main Directorate for Supervision of the Execution of Federal Legislation of the General Prosecutor’s Office of the Russian Federation — a department for supervision of the implementation of federal legislation in the Arctic regions and two specialized prosecutor’s offices (environmental and transport) with deployment in the Arctic zone of the Russian Federation, as well as the publication of departmental orders of the Prosecutor General of the Russian Federation.
Extrajudicial Protection of Citizens’ Rights: the Importance and Problems of Effective Activity of the Institute of Human Rights Commissioners in the Russian Federation
Authors: Stepkin S. P.
Published: September 2024

The article highlights the role and effectiveness of the work of human rights commissioners in the Russian Federation, emphasizing their importance in the system of protecting the rights and freedoms of citizens. The author analyzes the constitutional and legislative foundations of the activities of ombudsmen, and also examines the practical aspects of their work, including accessibility and taking into account regional characteristics, and highlights the existing shortcomings in the legal regulation of the activities of human rights ombudsmen. The article also touches on the transformation of the legal status of the ombudsman and his role in the judicial and extrajudicial protection of human rights, emphasizing its importance in both national and international contexts.
Criminal Procedural Function of the Prosecutor when Terminating a Criminal Case with the Imposition of a Court Fine
Authors: Marina E. V.
Published: September 2024

In the article is analyzed the role of the prosecutor in terminating a criminal case with the imposition of a criminal law measure in the form of a court fine. Attention is drawn to the fact that the traditional understanding of procedural functions can be changed in relation to this participant in criminal proceedings when it comes to releasing a person from criminal liability. The reason is the processes of functional convergence, which contribute to the unification of the supervisory function and the function of criminal prosecution when deciding to terminate a criminal case with the imposition of a court fine. The participation of the prosecutor is mandatory in the court hearing when a criminal case is terminated on this basis; the prosecutor also approves the request of the investigator, due to the fact that today only the court can impose a court fine, but the criteria by which the decision is made cannot be objectively established in criminal law, therefore the prosecutor acts as an additional guarantee of the protection of the rights of participants in criminal proceedings and the legality of the court decision.
Constitutionalization of Environmental Protection: Comparative Dimension
Authors: Vasilieva Т. A.
Published: September 2024

Modern comparative constitutional studies go beyond the analysis of traditional institutions. In particular, the process of constitutionalization of environmental protection is developing very dynamically. In the 1970s these issues were enshrined in four constitutions, at present they are contained in 157 constitutions of the countries of the world. The subject of constitutional regulation is significantly expanding: it includes the principles of environmental law, directions of environmental policy, environmental rights of future generations and institutional mechanisms for their protection. The evolution of constitutional provisions follows the drafting of soft international law norms. The countries of the global South are more active in this area of constitutional regulation than the countries of the global North. Certain regional approaches in this area have already emerged. Thus, in Latin American states there is a transition from anthropocentrism to ecocentrism, nature and its individual objects are recognized as subjects of law.
Coordination by the Prosecutor of the Activities of State Bodies to Protect the Property Interests of the State
Authors: Miloserdov N. A.
Published: September 2024

The article analyzes violations of laws detected by prosecutors that arise in the activities of state bodies authorized to carry out functions for the management, disposal and protection of state property, and suggests a mechanism for their resolution. Special attention is paid to the mechanism of interaction of the prosecutor with other state bodies, ways to increase the effectiveness of activities to protect the property interests of the state, in connection with which, based on the analysis of empirical material, in order to ensure consistency in the activities of authorized state bodies and strengthen the status of the prosecutor in the framework of protecting the property interests of the state, it is proposed to consolidate in the Federal Law of January 17, 1992. No. 2202-1 “On the Prosecutor’s Office of the Russian Federation” defines a new function of the prosecutor’s office in this area — “coordination of the activities of state bodies to protect the interests of the state in the field of property relations”, defining the concept of this legal definition, as well as formulations characterizing the subject, subjects and object of coordination activities. It is concluded that the implementation of this function in practice will contribute to the synchronization of the activities of all state bodies involved in protecting the property interests of the state and increase the efficiency of work on the recovery of property of public legal entities.
Association of cognitive status, anxiety and depression with hearing loss in the elderly
Authors: Gülmez Mehmet İhsan , Aydin Canset
Published: September 2024

Objective: Hearing loss is an important problem that is common among older people. Dementia can be defined as a group of disorders that adversely affect memory, thinking function and the ability to perform daily activities. Hearing loss leads to poor quality of life due to loneliness, social isolation, anxiety and susceptibility to depression. Hearing aids are the primary tool used in the management of hearing loss. In this study, we aimed to compare participants with and without hearing loss in terms of cognitive status, depression and anxiety, and to assess the effect of hearing aid use on this process.
Method: Between June 2023 and June 2024, 608 patients over the age of 50 who registered at the psychiatric outpatient clinic of Hatay Training and Research Hospital were included in the study. Participants were enrolled if they presented to the Psychiatry outpatient clinic during the selected time interval, were over 50 years of age and agreed to participate in the study. Participants' demographic information, educational status, social information, hearing aid use, minimental score, Beck anxiety score, and geriatric depression score were recorded.
Results: When comparing patients with and without hearing loss, statistically significant differences were observed on the Minimental Test, Beck Anxiety Score and Geriatric Depression Score.
Conclusion: In this study, a statistically significant relationship was found between hearing loss and cognitive status, depression and anxiety, and it was suggested that the use of hearing aids may be beneficial in terms of preventing the development or slowing the progression of these pathologies.
Perceived Physical Education Instructor’s Autonomy Support to Students’ University Engagement: Deciphering an unexplored issue in the case of a State University in the Philippines
Authors: Lobo Joseph , Masagca Ramon Carlo , Serrano John Mathew , Reyes Jessie , Esteban Martín James
Published: September 2024

Scholarly articles from various disciplines have established that instructor’s autonomy support positively influences students’ university engagement. On the one hand, studies that were conducted in relation to this current topic in the field of Physical Education, most specifically in the Higher Education context in the Philippines remain unexplored. In this regard, this present study investigated the direct influence of perceived instructor’s emotional support to students’ university engagement. Additionally, it also examined the direct influence of IAS to the three components of UE namely, vigor, dedication, and absorption. After surveying 702 students enrolled in Physical Education courses in a State University, it was unraveled that IAS has a significant and direct influence to UE. IAS also has a significant and direct relationship with VI, DE, and ABS. Based on the findings, PE instructors’ autonomy support is crucial as it enables students to assume responsibility for their fitness progress, cultivating a feeling of purpose and motivation. Autonomy-supportive instructors promote increased engagement and commitment in physical education classes by offering choices and encouragement in goal setting, potentially encouraging students to embrace a healthy active lifestyle even outside university. Recommendations and future research directions are also presented in this paper.
Preserving and strengthening physical culture by empowering multifaceted course engagement via individual interest in fitness and Sports
Authors: Lobo Joseph
Published: September 2024

This present study determines the direct influence of individual interests of students toward fitness and sports via course engagement in the promotion and preservation of physical culture inside the university. This study surveyed a total sample of 231 students taking fitness, sports coaching, and management at a state university. The results revealed that individual interest, along with its three important factors (positive affect and willingness to engage, stored utility value, and stored attainment value and knowledge-seeking intentions), is directly related to course engagement and its four components (skills, participation/interaction, emotional, and performance engagement). Therefore, it can be concluded that individual interest in fitness and sports is an important determinant of course engagement that may lead students to practice healthy living, even outside the academe. Limitations and future recommendations are hereby presented.
Efecto del entrenamiento de fuerza usando carácter del esfuerzo sobre el rendimiento en 50 metros en natación con aletas
Authors: Idarraga Tobón Luis Eduardo , Agudelo Velásquez Carlos Alberto , Ortiz Uribe Mariluz , Vidal Restrepo Juan Camilo , Calderón Uribe Alejandro , Monsalve Aguirre Juan Manuel , Echeverri Gil Johan Camilo
Published: September 2024

El entrenamiento de la fuerza en el ámbito deportivo ha evolucionado acorde a las demandas específicas de cada disciplina. En este contexto, este estudio busca establecer el efecto del entrenamiento de fuerza sobre el rendimiento en la prueba de 50 metros especialidad (Bi-aletas y superficie). Se estableció la 1RM de cada deportista para calcular su 50%, y posteriormente se hizo un test de repeticiones máximas para programa un Carácter del Esfuerzo (CE) del 50%. Se pretende ofrecer una contribución al cuerpo de conocimientos existentes, que favorezcan un mejor diseño de programas de entrenamiento específicos para optimizar el rendimiento de los velocistas en natación con aletas. El objetivo fue analizar el efecto de una intervención de fuerza en tierra de cinco semanas por CE en 11 nadadores con aletas integrantes de la selección Antioquia de tal modalidad que participó en los Juegos Nacionales 2023. Es un estudio pre-experimental sin grupo control con una población especializada de rendimiento en la que se utilizó como pre-test y pos-test los tiempos obtenidos en los 50 metros especialidad y como variable independiente utilizó un plan de ejercicios por CE para llevar a cabo la puesta a punto en fuerza. Como resultados no se encontraron mejoras estadísticamente significativas en los tiempos de la prueba evaluada. Se concluye que es posible que la metodología sea adecuada; sin embargo, con las limitaciones del estudio en cuanto a número de participantes y tiempos de intervención, no se obtuvieron mejoras significativas en los tiempos de la prueba.
Complement in ANCA vasculitis, insights on pathophysiology and targeted therapies
Authors: Srinivisa Vinay
Published: September 2024

Antineutrophil cytoplasmic antibody (ANCA) associated vasculitis (AAV) is a debilitating disease with the potential to cause significant morbidity and mortality if not treated. The pathogenesis of this disease is not understood, though emerging evidence suggests that alternative complement pathway system is involved. C5a, mediates several pro-inflammatory effects through its receptor C5aR. Avacopan, targets C5a by preventing it from binding to its receptor C5aR. Complement dysregulation, imbalance between regulatory activity of Factor H and stimulation by Factor H related proteins, has been identified as a new mechanism of disease.
Understanding New Power Communities and Leadership in Medicine and Health Professions: A Review of Concepts and Literature
Authors: Jefferson Kurt , Bloch Kristina , Claycomb Sytisha , Gaines Jill , Harris Elizabeth , Livers Destiny , Love Krissalyn , McCraney Paula , Rivera Carmen , Murphy Colleen , Overton Joshua , Ransan Mário , Shipp Kaci , Stimler Laura , Timmerberg Trevor
Published: September 2024

The authors’ review scholarly works in leadership studies and other fields and apply concepts and literature related to Heiman and Timms’ seminal work, New Power (2018), in order to understand the evolving area (as described by Heimans and Timms) of “new power communities.” New power communities can be found in medical and health professions organizations today. Moreover, the importance of social media, crowdsourcing, and the impact of broad-based mass movements in democratic polities, along with the use of new technologies, has caused a reorientation of human networking and interaction. The article discusses the following literature: Naím’s The End of Power (2013), Jefferson, et al.’s “New Power through the Lenses of Leadership Studies, Psychology, and Politics” (2016), Shultz’s Learning from Experience (2016), and Slaughter’s The Chessboard & the Web (2017). Each of these works can inform our analysis of “new power,” community, leadership, and other concepts that helps us analyze and contextualize Heimans and Timms’ New Power in ways that allow us to not only understand the concept of “new power” better, but also understand how leadership, community, and power impact medicine and the health professions. Methodologically, this review study employs a qualitative systematic review approach (see Anh and Kang, 2018). In attempting to understand better the concepts of “new power” and “new power communities,” the authors provide an empirical analysis of new power communities in digital spaces emerging in various contexts including medicine and health professions.
Impact of gingival tissue type around Dental implants on implant health and longevity: A Case report on implants around mandibular overdenture
Authors: Soolari Ahmad , Soolari Amin , Obiechina Nkem
Published: September 2024

The type of gingival tissue around dental implants is extremely important for the health and longevity implants in the mouth. Gingival tissue around dental implants can be comprised of keratinized or non-keratinized mucosal tissue. The type of soft tissue present around implants can influence the health, plaque accumulation and inflammation around dental implants. A number of studies have found that there is a need to have a minimum amount of keratinized mucosa to maintain peri-implant health especially for patients with poor oral hygiene that are at greater risk of gingival inflammation others have not found the same correlation for patients with good oral hygiene practices. More recently, a number of studies have found less potential for inflammation in sites with keratinized mucosa compared to non-keratinized mucosal tissue. The goal therefore is that when non keratinized mucosal tissue is present to utilize a soft tissue grafts to be able to regain keratinized mucosa around the implant site. This is particularly important for implant supported Overdentures where gingival augmentation can be able to improve oral hygiene, and help with resistance to trauma and abrasion from the removable prosthesis. This Case report is on utilization of a free gingival graft to increase keratinized mucosa, combined with a vestibuloplasty to increase vestibular height around implants supporting a mandibular overdenture prosthesis with the goal of improving the health and longevity of the implant supported overdenture.
Addictive Behavior and Evolutionary Adaptation: Mitigated through Genetic Addiction Risk Severity Early Identification and Awareness Integration Theory
Authors: Zeine Foojan , Jafari Nicole , Manoukian Eileen , Blum Kenneth
Published: September 2024

Objectives: Humans, with their unique genetic profile, exhibit a greater propensity to develop and maintain addiction compared to other animals. This paper offers a detailed examination of addiction, co-occurring traits, and psychologic disorders, focusing on neurobiological and molecular aspects. Furthermore, the authors investigate the potential of the Awareness Integration Theoretical model as an effective therapeutic addiction treatment. Methods: Using PsychINFO, PubMed, and Google Scholar, a comprehensive literature review was conducted on the evolutionary and adaptation pathways to addiction, epigenetic factors, and the potentiality of Awareness Integration Theory in treating addiction. Results: Epigenetics allows environmental factors to create lasting and heritable phenotypic changes, enabling rapid adaptation to these stimuli. Addiction “high-jacks” this system and the neurochemical mechanisms that control flexibility and innovation and is, thus, the price we pay for adaptability. Drug addiction is thought of as an adjunctive behavior or a subordinate behavior catalyzed by more profound, more significant psychological and biological stimuli. Conclusions: The neurochemical mechanisms underlying addiction, a complex interplay of genetic and environmental factors, are intertwined with the hallmark features of the human species, such as behavioral flexibility and pre-addictive propensity. The dopaminergic system, a key player in addiction, serves as a crucial link between addiction and the shared genetic profile evident in co-occurring traits and psychiatric and psychological disorders. Furthermore, a hypofunctioning dopaminergic system is a common characteristic of addiction and co-occurring psychiatric and psychological disorders. Early childhood preventative measures are vital in re-directing the existing predictive and poor adaptability functioning, which refers to the individual's inability to adapt to changing circumstances and reliance on maladaptive coping strategies. Awareness Integration Theory’s approach encompasses a therapeutical model addressing individuals' physical, cognitive, and psychosocial domains, allowing the individual to address intergenerational and ancestral ineffective and harmful adaptability. This, in turn, AIT will allow the human genome to be on a healthier path to recovery from obstacles such as addiction. When a tendency or a characteristic improves your ability to function and survive, and especially your ability to produce and raise children, that will most likely break the cycle of addiction and addictive behavior.
Intelligent Insights for Noninvasive Aortic Valve Stenosis therapeutics
Authors: Alabdulgader Abdullah
Published: September 2024

Stagnation of therapeutic options is a prominent feature of valvular aortic stenosis(AS). Invasive therapeutic options in the form of open heart aortic valve surgery or transcatheter aortic valve implantation (TAVI) are still the only therapeutic options until the moment. Decoding the mystery of AS morphogenesis is a challenging endeavor. It is only possible by multidisciplinary approach emanating from epidemiological back ground. Eagle eye observations of clinical correlates as well as prudent research in the molecular , genetic and epigenetic arena targeting decoding the genesis involved in bicuspid aortic valve formation are critical demands to throw stone in the stagnant lake. Hybrid pharmaceutical therapies combined with effective physical therapies will pave the way for future breakthroughs targeting noninvasive therapeutic options for valvular aortic stenosis or even aborting the disease in human species.
Competency Based Human Anatomy Volume I (Second Edition)
Authors: Kumar Dr. A. Prasanna Veera
Published: September 2024

The CBME curriculum which has started from 2019 MBBS batch requires changes in teaching undergraduate medical students from the traditional method to focus on outcome-based learning. As per the new CMBE curriculum the subject of anatomy has been delineated into competences. To cover all the competencies no single anatomy text book is available in the market. In this book an attempt has been made by the author to deal with all the competencies serial wise, to eliminate the confusion both for the students and teaching faculty while following the available text books. The book is presented in a style which is totally new to the subject of anatomy. Each competency is dealt briefly and up to the level of knowledge required for MBBS students giving details of its learning objective, its domain and the assessment method. Wherever the competency includes anatomical basis the same is given utmost importance, so that students do not suffer from the tedious work of searching for the required study material. All the competencies are dealt in such a manner that the student is at ease while studying the subject of Anatomy in the 1st phase of MBBS curriculum. The book is useful for MBBS students, and PG-NEET preparation and also the anatomy teaching faculty. The new second edition includes over 100 line diagrams and more than 800 multiple-choice questions, organized by region and chronologically according to the competencies of the CBME curriculum: General Anatomy (115), Upper Limb (240), Lower Limb (250), and Thorax (255). These additions will be very helpful for MBBS students and for the NEXT Exam 2025.
A comercialização do tucumã (Astrocaryum aculeatum) por extrativistas em comunidades ribeirinhas do Amazonas
Authors: Silva Lindomar de Jesus de Sousa , Schneider Sergio , Santos Alessandro Carvalho dos , Meneghetti Gilmar Antonio , Pinheiro José Olenilson Costa , Alves Rosilane Bruna de Souza
Published: September 2024

O artigo traz o resultado da pesquisa sobre os canais de comercialização do tucumã, produto do extrativismo e que expressa um aspecto da cultura alimentar dos amazonenses. A pesquisa foi realizada em três comunidades (São Francisco do Mainã, Jatuarana e Novo Progresso) localizadas à margem esquerda do Amazonas, e com agricultores da região do Puraquequara, Manaus – AM. A pesquisa teve um viés quantitativo e qualitativo. Ao todo, foram entrevistados 30 agricultores que fazem o extrativismo do tucumã. A pesquisa mostrou a dinâmica de comercialização do tucumã, quantificando e lançando luz sobre os canais de comercialização, as relações que se estabelecem na comercialização e mostra as debilidades dos atores envolvidos, de um modo especial os agricultores extrativistas. As informações podem auxiliar na elaboração de ações de apoio aos atores envolvidos na atividade.
Restauração ecológica para o SocioBioCotidiano: Nexus + no contexto da catástrofe climática no território do PAN Lagoas do Sul
Authors: Souza Gabriela Coelho-de , Mello Ricardo Silva Pereira , Taboada Júlia Kuse , Miranda Tatiana Mota
Published: September 2024

Nexus+ inter-relaciona as seguranças hídrica, energética, alimentar e socioambiental, agenda promovida no território do PAN Lagoas do Sul por meio da restauração ecológica para o SocioBioCotidiano. Nesse território, a porção da região metropolitana de Porto Alegre e da Laguna dos Patos foi severamente impactada pelas enchentes de 2024. Nesse contexto, objetivou-se analisar a restauração ecológica para o SocioBioCotidiano como estratégia para o alcance das seguranças no contexto das emergências climáticas. Com esse fim, foram realizadas análises documental e de literatura com vistas a caracterizar a emergência climática e analisar o potencial de alcance das seguranças pelas espécies e ecossistemas. Todos os ecossistemas apresentaram serviços ecossistêmicos que garantem as seguranças em nível local e regional, concorrendo para a resiliência dos territórios urbanos. A noção de SocioBioCotidiano se apresenta como uma estratégia regional de abastecimento que promove a conservação e restauração da biodiversidade, a mitigação das mudanças climáticas e a justiça socioambiental.
Application of Machine Learning in Clustering Maize Producing Regions in Indonesia
Authors: Eliyani Eliyani , Dwiasnati Saruni , Arif Sutan Mohammad , Avrizal Reza , Fatimah Nona
Published: September 2024

Maize is considered an important commodity with promising market prospects. Given the importance of maize, there is a need to increase maize production to meet people's needs and maintain price stability. This study aims to group maize production in Indonesia by region, with the hope of finding areas that have the potential to become maize production centers to reduce dependence on imports. The data used in this research was obtained from the Central Statistics Agency, covering information from 34 provinces during the 2017-2021 period. This analysis uses the K-Means method with the Python programming language. The number of groups is determined using the Elbow Method. The results of this research show that there are three categories of maize production regions: regions with low maize production (below average), regions with medium maize production, and regions with high maize production. A total of 25 provinces are in the low production category, eight provinces are in the medium category, and only East Java is in the high production category.
Image Classification of Traditional Indonesian Cakes Using Convolutional Neural Network (CNN)
Authors: Azizah Azkiya Nur , Budiman Irwan , Indriani Fatma , Faisal Mohammad Reza , Herteno Rudy
Published: September 2024

Indonesia is one of the countries famous for its traditional culinary. Traditional cakes in Indonesia are traditional snacks typical of the archipelago's culture which have a variety of textures, shapes, colors that vary and some are similar so that there are still many people who do not know the name of the cake from the many types of traditional Indonesian cakes. The problem can be solved by creating a traditional cake image recognition system that can be programmed and trained to classify various types of traditional Indonesian cakes. The Convolutional Neural Network method with the AlexNet architecture model is used in this research to predict various kinds of traditional Indonesian cakes. The dataset used in this research is 1846 datasets with 8 classes of cake images. This study trained the AlexNet model with several optimizers, namely, Adam optimizer, SGD, and RMSprop. The best parameters from the model testing results are at batchsize 16, epoch 50, learning rate 0.01 for SGD optimizer and learning rate 0.001 for Adam and RMSprop optimizers. Each optimizer tested produces different accuracy, precision, recall, and f1_score values. The highest test results that have been carried out on the image dataset of typical Indonesian traditional cakes are obtained by the Adam optimizer with an accuracy value of 79%.
Sinonasal Anatomic Variations in Headache Etiology
Authors: Yüksel Özlem , Bilir Ahmet Berkan , Akpınar Meltem Esen
Published: September 2024

Objective: Headache is a frequent clinical symptom with multiple etiologies. Our purpose is to investigate the correlation between variations in sinonasal anatomy and headaches.
Methods: We retrospectively evaluated the paranasal computed tomography (CT) scans of patients with and without headaches. 118 patients presenting with headaches were included in the study group and 63 patients without headaches were included in the control group. Eight common anatomic variations were clarified and recorded in both groups regardless of whether unilateral or bilateral. Statistical analyses were performed with NCSS (Number Cruncher Statistical System) 2007 software. The results were evaluated at a significance level of p
Developmet of Android E-book Forms of Energy to Improve Students' Critical Thinking and Mathematical Representation Skills
Authors: Nugraheni Kanthi , Kuswanto Heru , Jumadi Jumadi
Published: September 2024

Critical thinking and mathematical representation skills play an important role for students, especially in physics. This research’ aims are to study the feasibility and effectiveness of the android e-book forms of energy to improve students' critical thinking and mathematical representation skills. This research was developed using the ADDIE model. The experimental design was one group pretest posttest. This research found that the E-book were feasible to be applied in physics learning. It content qualify the writing and content requirements for a physics E-book. The android e-book is effective for improving students' ability in interpretation and explanation, effective enough in analyze, and less effectively in the inference and argument and evaluation aspects. E-book is less effective in the aspect use pictures, graphs, tables, or diagrams to solve problems and effective enough in training students use symbols or mathematical equations in solving problems and explain data or other representations in sentence form. The global N-Gain value shows that the Android e-book forms of energy is effective enough to improve critical thinking and mathematical representation skills.
Improvement Student Learning Outcomes Through Online Learning Using Nearpod
Authors: Purba Leony Sanga Lamsari
Published: September 2024

This research is a quantitative descriptive study with a one group pretest posttest research design. The population in this study were 61 public high school students in East Jakarta, and the sample used was 72 students. The data collection technique is to do a pretest and posttest using multiple choice questions that have been validated as many as 21 questions with options A, B, C, D and E. The results of data analysis, namely the hypothesis test paired sample test using SPSS 24, the results are ttable=1.66 < tcount =7.35 for df=71 indicates that the alternative hypothesis is accepted with sig.0.00 (<0.05),  thus an increase in student chemistry learning outcomes in online learning using nearpod, with paired sample t test. Further analysis using gain test obtained a gain score of 0.22 low category, this is possible because students are still in the system adjustment stage learning from full offline to full online.
O “novo” Ensino Médio e suas implicações socioeducacionais
Authors: Trindade Debora Cristine , Orso Paulino José
Published: September 2024

Este artigo trata do “novo” Ensino Médio e suas implicações para a educação e para a sociedade. Considerando que vivemos em uma sociedade de classes, na qual a neutralidade é impossível, as políticas educacionais, como é o caso da Reforma do Ensino Médio e da Base Nacional Comum Curricular – BNCC, não têm o mesmo significado para os indivíduos situados em diferentes classes sociais. Diante disso, o problema que orienta essa pesquisa está em compreender, o atual contexto de desenvolvimento do capital, as implicações dessas políticas e reformas educacionais para a classe detentora do poder, a burguesia, e para os trabalhadores, desprovidos da propriedade dos meios de produção e, por outro, apontar os desafios que se colocam para os educadores comprometidos uma educação com qualidade socialmente referenciada. Este trabalho, parte de uma pesquisa de doutorado que se encontra em andamento e tem um caráter bibliográfico e documental. Conclui-se que a subordinação política empresarial tem desqualificado o trabalho docente e a formação da juventude brasileira, especialmente os filhos e filhas da classe trabalhadora que dependem exclusivamente da escola para o acesso aos conhecimentos históricos, sendo uma tarefa dos educadores a luta pela pelas mudanças políticas e pela superação da fragmentação do conhecimento.
Evaluation of German Life Insurers Based on Published Solvency and Financial Condition Reports An Alternative Model
Authors: Lyra Sven , Dill Arthur
Published: September 2024

German life insurance companies were selected for a complete survey. Quantitative data relevant to the analysis was extracted from the individual Solvency and Financial Condition Reports reports and transferred to a systematic overview. To make the collected observations usable, they were transformed into various growth, profitability, and security ratios cited in the literature, thus enhancing comparability. The data transformed into ratios were presented in histograms with ten intervals each, and a score between one and ten was assigned depending on the ratio value. In addition, four qualitative risk categories were initially identified, based on which the model would be operationalized. These were underwriting risk, market risk, credit risk and operational risk. Artificial intelligence was used to design seven questions on the requirements of Article 295 of Delegated Regulation 2015/35. Specifically, there were questions on the methodology of risk assessment, the description of specific measures, the comprehensibility of the measures, information on risk concentrations and the impact on the risk profile of the company as a whole, and risk mitigation measures and their effectiveness. Points were awarded from one to four, depending on the quality of the text used to answer the questions, based on the Appelfeller and Feldmann maturity model. This was followed by a weighting with individual factors to reflect the importance of each metric. While consumers can, for example, simply use the indexed total score for further consideration, the model equation can also be filled with fictitious values. This makes it possible to predict the risk class of a fictitious life insurer in the German market in 2022.The analyses show that it is in principle possible to extract both quantitative and qualitative assessment elements from the respective solvency reports, transform them into meaningful ratios, and finally combine them in a weighted model to generate a decision-making basis for the model user. It is precisely the dovetailing of the two strands of quantitative and qualitative analysis that makes it possible to make meaningful use of information that was previously not taken into account.
Influence of Seasons on Production Performance of Commercial Layer Chicken in Southern Region of Telangana
Authors: Kumaravel V. , Reddy M. Govardhan , Vasanthakumar P.
Published: September 2024

Background: Effective management strategies and feeding practices are essential for mitigating the challenges presented by the extreme temperatures of the summer season and the increased humidity and disease risk during the wet season. Adapting to these seasonal variations is crucial for maintaining a successful and profitable layer chicken farming. Methods: Influence of seasons (summer, rainy and winter) on production performance of layer chickens in different production cycles (Phase I, II, III and IV) was studied. The commercial layer chicken farms from southern Telangana region were selected with bird capacities ranging from 1.0 to 1.5 lakhs, rearing BV-300 breeds, aged 19-83 weeks, housed in elevated cage systems were randomly chosen. The data was collected from farm records, pre-structured questionnaires and personal interviews. Result: Summer (Phase I: 19-30 weeks) showed decreased egg production (70.57%), increased broken eggs (1.50%) and lower livability (99.95%). Egg production showed improved performance during the winter (90.22%) and rainy seasons (89.40%) in Phase II (31-50 weeks), highlighting the importance of seasonal adjustments for enhancing productivity. Phase III (51-72 weeks) also demonstrated rainy and winter seasons consistently yielding better results, with rainy season notably excelling in higher egg production (89.70%). Phase IV (72 weeks and above) highlighted winter’s superiority in egg production (79.70%) and reduced broken eggs (0.57%), emphasizing the importance of adapting poultry farming practices to mitigate the climatic variability.
Theo-Anthropological Approach to the Secret Curriculum in Addressing Youth’s Moral Breakdown
Authors: Nyamai Dinah Katindi
Published: September 2024

Every young person can benefit from meaningful mentorship. The quality of mentorship social emotional environments is an essential mediating factor. The current research highlights the importance of a sound theo-anthropological view of the secret curriculum in youth holistic nurture to effectively address youths’ moral breakdown.
DINASTI ILKHAN : PEMBARUAN BIDANG EKONOMI MAHMUD GHAZAN KHAN 1295-1304 M
Authors: Ilhamzah Ilhamzah
Published: September 2024

Keberhasilan seorang pemimpin dapat di lihat dari kebijakannya dalam menjalankan roda pemerintahan dan usahanya untuk kesejahteraan masyarakat. Dalam sejarah Islam banyak mencatat tokoh pemimpin yang berhasil dalam kepemimpinannya, salah satunya ialah Ghazan Khan.  Ghazan dikenal sebagai pemimpin yang berhasil dan dicintai rakyatnya dan membawa kekuasaan Islam menjadi daulah yang besar dibawah naungan Mongol Islam dengan gebrakan pembaruannya di bidang ekonomi. Dalam tulisan ini memfokuskan pada tokoh Ghazan Khan sebagai penguasa muslim yang menjalankan pemerintahnnya dengan tanggung jawab atas dasar nilai-nilai Islam dengan melihat bagaimana latar belakang kehidupannya dan kebijakan-kebijakannya dalam bidang ekonomi yang dalam banyak hal memberikan kontribusi demi kelangsungan kehidupan perekonomian Islam dan kejayaan Islam.
KH. ALI UMAR THOYYIB (1952-2008) (KONTRIBUSINYA DALAM PERKEMBANGAN ISLAM DI PALEMBANG)
Authors: Ihsan Ahmad Fajrul , Otoman Otoman
Published: September 2024

Tulisan ini mengkaji tentang bagaimana kontribusi dari KH Ali Umar Thoyyib dalam perkembangan Islam di Palembang. Kajian dalam tulisan ini membahas secara komprehenshif tentang bagaimana kontribusi KH Ali Umar Thoyyib dalam perkembangan Islam di Palembang, Mulai dari tahun 1952 sampai 2008. Banyak peneliti lain mengkaji tentang ulamaulama yang besar dan cukup dikenal publik, di sisi yang lain bila di telaah lebih jauh kontribusi KH Ali Umar Thoyyib dalam perkembangan Islam juga cukup signifikan, dan selama ini belum ada penelitian yang membahas tentang kontribusi beliau dalam perkembangan Islam di Palembang. Peneliti merasa penting untuk mengkaji bagaimana kontribusi KH. Ali Umar Thoyyib dalam perkembangan Islam Di Palembang, karena ada alasan yang membuat penelitian ini menarik. Yaitu; tentang figur KH. Ali Umar Thoyyib sebagai ulama lokal yang sangat berperan aktif dalam perkembangaan Islam Di Palembang dan selama ini tidak ada pembahasan yang cukup siknifikan tentang beliau. Berpijak dari argumen tersebut maka, pertanyaan besar dari penelitian ini adalah bagaimana kontribusi KH. Ali Umar Thoyyib dalam perkembangam Islam Di Palembang. Guna mengelola data yang didapat guna memperoleh hasil analisis yang maksimal, dalam penelitian ini menggunakan teori peranan. Dalam penelitian ini penulis menggunakan metode historis yang bertujuan untuk merekonstruksi masa lalu secara sistematis dan objektif dengan mengumpulkan, mengevaluasi serta menganalisa bukti-bukti untuk menguak fakta dan meperoleh kesimpulan yang sangat kuat. Temuan dalam penelitian ini adalah KH. Ali Umar Thoyyib, merupakan salah satu tokoh penting dalam perkembangan Islam di Palembang.