bluuebunny/crossref_metadata_2025 huggingface dataset:
Where is the Origin of the Last Normal Branch from Feeding Artery of Pulmonary Arteriovenous Malformations?
Authors: Maruno Miyuki , Kiyosue Hiro , Hongo Norio , Matsumoto Shunro , Mori Hiromu
Published: August 2018

Purpose

Reperfusion via pulmonary-to-pulmonary arterial anastomoses is known as one type of recurrence of pulmonary arteriovenous malformations (PAVMs) after embolization. It is important to occlude the fistulous portion beyond the origin of the last normal branch from feeding artery of PAVMs to prevent recurrence. In this study, we evaluate the origin of the last normal branch by CT as well as its visibility on pulmonary arteriography (PAG).

Materials and Methods

We reviewed forty patients with 77 PAVMs who underwent coil embolization between October 2007 and December 2017. All patients underwent MDCT before embolization. Axial and MPR CT lung images were reviewed with special interests in the origin of the last normal branch from feeding artery of PAVMs. The origin was classified into three portions, including sac, junction (portion just proximal to the sac) and proximal feeder (more than 5 mm proximal to the sac). We also evaluated whether PAG can depict the normal branches detected by MDCT.

Results

MDCT showed that the last normal branch originated from sac in 30 PAVMs (39.0%), junction in 39 (50.6%), and proximal feeder in 8 (10.4%).On selective PAG, the last normal branch could be visualized in 30 PAVMs (39.0%), although it could not be visualized due to high-flow shunt in the other 47 PAVMs.

Conclusions

Selective PAG frequently fails to demonstrate the last normal branch from feeding artery of PAVMs, which often originates from the sac. Pretherapeutic evaluation of CT images of the last normal branch is important to prevent reperfusion of PAVMs.

Level of Evidence

Level 3, local non-random sample.
Statistical test for detecting overdispersion in offspring number based on kinship information
Authors: Akita Tetsuya
Published: August 2018

In this paper, we develop a theory of a new statistic that tests overdispersion in offspring number on the basis of exactly known kinship relationships. The statistic utilizes the sample size and the number of kinship pairs found in a sample, specially the number of mother–offspring (MO) and maternal–half‐sibling (MHS) pairs. Given a sufficiently large sample size, the statistic proposed in this paper approximately follows a standard‐normal distribution under non‐overdispersed conditions (Poisson's variance). We found that (1) the value of the statistic ( or ) reasonably indicates whether reproduction is overdispersed at the 5% significance level; (2) the power of the statistic is determined primarily by the balance between the degree of overdispersion and the sample size; (3) in many cases, if the number of kinship pairs can be approximated by a normal distribution, false‐positive and false‐negative situations can be avoided. The proposed method can detect moderate‐weak levels of overdispersion that produce few MHS pairs in a sample because the effect of the population size (which determines the number of detected MHS pairs) is canceled by the detection of the number of MO pairs. Once the kinship determination procedure is established, this indirect measurement will be readily applicable to species even with weak overdispersion, expanding the available opportunities for understanding how overdispersion in offspring number affects ecological processes.
Review and Case Studies of Midthigh Femoral Central Venous Catheter Placement
Authors: Ostroff Matthew , Moureau Nancy , Ismail Mourad
Published: August 2018

Background: Bedside vascular access options have been limited to the short peripheral intravenous, midline catheter, peripherally inserted central catheter, and central venous catheter (CVC) insertion sites such as the jugular, subclavian, and femoral vein. Many patients with limited options for upper extremity, subclavicular, supraclavicular, and cervical limitations have traditionally received a femoral CVC in the inguinal region. This insertion site is considered a high risk for infection because of its location in the inguinal region and associated difficulties with maintaining the dressing integrity. An alternative location was selected for the insertion of a femoral vein central venous catheter in the midthigh to reduce the risk of infection.

Methods: After a multiple-year implementation process, midthigh femoral (MTF) insertions were performed on a select group of patients. The case studies that are included in this report outline the indications, procedures, and other pertinent aspects of the MTF placement. Patients at this institution with contraindications to upper extremity and thoracic catheter insertion received a MTF vein CVC in place of a traditional common femoral vein catheter insertion in the inguinal area. All procedural consents include permission for photography of procedure sites.

Results: All but a single patient completed their therapy without complication; 1 intentional dislodgement by a patient was recorded. There were no MTF catheter-related bloodstream infections and 2 confirmed central line associated bloodstream infections (n = 2 of 100) with the second noted as probable contaminated specimen. Outcomes reflected no procedural complications (eg, expanding hematoma or femoral nerve injury or any other femoral artery or vein injuries) and 1 nonocclusive deep vein thrombosis (n = 1 of 100).

Conclusions: The MTF CVC provides an alternative to traditional common femoral vein catheter placement for nonemergent patients with upper extremity and thoracic contraindications to central line placement.
Message and Environment: a framework for nudges and choice architecture
Authors: CONGIU LUCA , MOSCATI IVAN
Published: August 2018

We argue that the diverse components of a choice architecture can be classified into two main dimensions – Message and Environment – and that the distinction between them is useful in order to better understand how nudges work. In the first part of this paper, we define what we mean by nudge, explain what Message and Environment are, argue that the distinction between them is conceptually robust and show that it is also orthogonal to other distinctions advanced in the nudge literature. In the second part, we review some common types of nudges and show they target either Message or Environment or both dimensions of the choice architecture. We then apply the Message–Environment framework to discuss some features of Amazon's website and, finally, we indicate how the proposed framework could help a choice architect to design a new choice architecture.
A Critical Evaluation of the State of Assessment and Development for Senior Leaders
Authors: Reynolds Douglas H. , McCauley Cynthia D. , Tsacoumis Suzanne ,   The Jeanneret Symposium Participants
Published: August 2018

Practice and research with senior leaders can be rewarding but also challenging and risky for industrial and organizational (I-O) psychologists; the fact that much of the work with these populations is difficult to access elevates these concerns. In this article we summarize work presented by prominent researchers and practitioners at a symposium organized to share common practices and challenges associated with work at higher levels of organizational management. We review implications for research and practice with senior leaders by examining how assessments are applied at senior levels, how assessments and development practices can be linked, and the challenges associated with research and evaluation conducted with these leaders. Also, we offer suggestions for advancing research and practice at senior levels.
Servant Leadership and Follower Creativity Via Competence: A Moderated Mediation Role of Perceived Organisational Support
Authors: Thao Nguyen Phan Hanh , Kang Seung-Wan
Published: August 2018

The precedents of creativity comprise an important research topic that could help organisations survive fierce competition. To contribute to the literature on creativity, the authors examined the roles of competence and perceived organisational support (POS) in the relationship between servant leadership and follower creative behaviour. The authors proposed and tested a moderated mediation model with data from leader-follower dyads collected in a Vietnamese engineering firm. The results showed that follower competence is a significant mediator of the relationship between servant leadership and follower creativity. Furthermore, POS has a moderated mediating role, such that the mediated relationship (i.e., servant leadership, competence, and creativity) is more salient under high POS than under low POS. Theoretical and practical implications are discussed.
Office-Selling, Corruption, and Long-Term Development in Peru
Authors: GUARDADO JENNY
Published: August 2018

The paper uses a unique hand-collected dataset of the prices at which the Spanish Crown sold colonial provincial governorships in seventeenth and eighteenth century Peru to examine the impact of colonial officials on long-run development. Combining provincial characteristics with exogenous variation in appointment criteria due to the timing of European wars, I first show that provinces with greater extraction potential tended to fetch higher prices and attract worse buyers. In the long run, these high-priced provinces have lower household consumption, schooling, and public good provision. The type of governors ruling these provinces likely exacerbated political conflict, ethnic segregation, and undermined institutional trust among the population.
Effects of pea with barley and less-processed maize on glycaemic control in diabetic dogs
Authors: Teixeira Fabio A. , Machado Daniela P. , Jeremias Juliana T. , Queiroz Mariana R. , Pontieri Cristiana F. F. , Brunetto Marcio A.
Published: August 2018

The source of starch may interfere with glycaemic control in dogs, but few studies have evaluated these aspects in diabetic dogs. This study compared the effects of two isonutrient diets with different starch sources, peas and barley (PB)v. maize (Mi), on diabetic dogs. The Mi diet was processed in order to generate a lower starch gelatinisation index. In all, fifteen adult diabetic dogs without other conditions were included. The animals were fed two dry extruded rations with moderate levels of fat and starch and high levels of protein and fibre using a random, double-blind cross-over design. Glycaemic curves over 48 h were developed via continuous glucose monitoring after 60 d on each diet and with the same neutral protamine Hagedorn (NPH) insulin dosage. The following were compared: fasting, mean, maximum and minimum blood glucose, maximum and minimum glycaemia difference, glycaemic increment, area under the glycaemic curve, area under the glycaemic increment curve and serum fructosamine concentration. Pairedttests or Wilcoxon signed-rank tests were used to compare the amount of food and nutrients ingested and the dietary effects on glycaemic variables between the diets. Dogs fed the PB diet presented a lower average mean interstitial glucose (P=0·01), longer mean hypoglycaemic time (P<0·01), shorter mean hyperglycaemic time (P<0·01) and smaller difference between maximum and minimum blood glucose levels (P=0·03). Thus, the processing applied to the Mi diet was not sufficient to achieve the same effects of PB on glycaemic control in diabetic dogs.
Geological evolution of the Chalk Group in the northern Dutch North Sea: inversion, sedimentation and redeposition
Authors: VAN DER VOET EVA , HEIJNEN LEONORA , REIJMER JOHN J. G.
Published: August 2018

In contrast to the Norwegian and Danish sectors, where significant hydrocarbon reserves were found in chalk reservoirs, limited studies exist analysing the chalk evolution in the Dutch part of the North Sea. To provide a better understanding of this evolution, a tectono-sedimentary study of the Late Cretaceous to Early Palaeogene Chalk Group in the northern Dutch North Sea was performed, facilitated by a relatively new 3D seismic survey. Integrating seismic and biostratigraphic well data, seven chronostratigraphic units were mapped, allowing a reconstruction of intra-chalk geological events.

The southwestward thickening of the Turonian sequence is interpreted to result from tilting, and the absence of Coniacian and Santonian sediments in the western part of the study area is probably the result of non-deposition. Seismic truncations show evidence of a widespread inversion phase, the timing of which differs between the structural elements. It started at the end of the Campanian followed by a second pulse during the Maastrichtian, a new finding not reported before. After subsidence during the Maastrichtian and Danian, renewed inversion and erosion occurred at the end of the Danian. Halokinesis processes resulted in thickness variations of chalk units of different ages.

In summary, variations in sedimentation patterns in the northern Dutch North Sea relate to the Sub-Hercynian inversion phase during the Campanian and Maastrichtian, the Laramide inversion phase at the end of the Danian, and halokinesis processes. Additionally, the Late Cretaceous sea floor was characterized by erosion through contour bottom currents at different scales and resedimentation by slope failures.
Temperature as a key factor for successful inoculation of soybean with Bradyrhizobium spp. under cool growing conditions in Belgium
Authors: Pannecoucque J. , Goormachtigh S. , Ceusters J. , Debode J. , Van Waes C. , Van Waes J.
Published: August 2018

Bacterial inoculation of soybean seeds to improve biological nitrogen fixation is a well-known practice to achieve higher seed and protein yield with reduced fertilization. The optimal inoculation strategy in temperate regions is unknown because soybeans are rarely cultivated under colder growing conditions. The aim of the present work was to determine the most suitable inoculation strategy for soybean cultivation in Belgium. Field trials were set up with four Bradyrhizobium inoculants (HiStick, Force 48, Biodoz and Optimize) at two locations over 2 years (2014–2015) and compared with a non-inoculated control treatment. In addition, HiStick was tested at three doses and Optimize at two time periods prior to sowing. Under Belgian conditions, all inoculants were effective in establishing rhizobial symbiosis, resulting in increased yield, protein content, protein yield and thousand-grain weight compared with the non-inoculated control. A single dose of HiStick was sufficient to establish symbiosis. Pre-inoculation with Optimize 2 weeks before sowing gave an intermediate performance for most parameters between the non-inoculated control treatment and inoculation with Optimize 24 h prior to sowing. Among the four products tested, Biodoz seemed the best product for inoculation under cool growing conditions. Based on the atpD gene, the bacterial strain of Biodoz showed complete similarity with Bradyrhizobium diazoefficiens, while strains of other products were identified as Bradyrhizobium japonicum. In vitro growing capacity of the Biodoz strain at 8 °C was higher compared with the other strains. Better cold adaptation of the Biodoz strain might be a possible explanation for the better performance of Biodoz in Belgium.
Changes occurring in stabilized ultra-high-temperature-treated whole milk during storage
Authors: dos Santos Fernando César , da Cunha Fabiano Érisson , de Pádua Alves Érika , de Almeida Bergonse Pereira Flávia , de Santana Elsa Helena Walter , Botaro Bruno Garcia
Published: August 2018

This Research Communication describes the relationship between casein, free fatty acids (FFAs) and the storage period of ultra-high temperature-treated (UHT) whole milk observed for a period of 120 d of labelled shelf-life. Moreover, we aim to estimate the daily rate of casein degradation in UHT whole milk, and the total length of time estimated for its full degradation. With this aim, ten sets of samples were evaluated from batches of UHT milk manufactured by a dairy processing plant in Parana State, Brazil on 10 different days. Each set was comprised of one liter of raw milk and 12 units of 1 litre cartons of UHT milk, and represented one batch of production. Total mesophilic (TMC), psychrotrophic (TPC), and somatic cell counts (SCC) of raw milk were assessed. UHT milk was assessed for fat (%), sialic acid (mg/l), casein (%), and FFA contents. TMC ranged from 3·5 × 106 to 3·1 × 107 CFU/ml; TPC, from 106 UFC/ml and higher; and SCC, from 18 × 104 SC/ml to 4·83 × 105 CS/ml. Casein (r = −0·991; R2 = 0·9822) and FFA (r = 0·962; R2 = 0·9245) contents, and storage time of UHT milk were correlated (P < 0·05). The rate of casein hydrolysis was estimated as 0·021 g/100 g UHT whole milk/day. A complete breakdown of casein was estimated to occur by the 560th day post-manufacture. Although age gelation was not observed in our study, the report herein corroborates the understanding that the microbiological quality and SCC of raw milk are important components involving the integrity of casein and lipids of UHT milk during shelf-life.
The Effect of Cultural Similarity on Mergers and Acquisitions: Evidence from Corporate Social Responsibility
Authors: Bereskin Fred , Byun Seong K. , Officer Micah S. , Oh Jong-Min
Published: August 2018

We study the effect of corporate cultural similarity on merger decisions and outcomes. Using the similarity in firms’ corporate social responsibility characteristics to proxy for cultural similarity, we find that culturally similar firms are more likely to merge. Moreover, these mergers are associated with greater synergies, superior long-run operating performance, and fewer write-offs of goodwill. Our evidence is consistent with the notion that cultural similarity eases post-deal integration. Our results contribute to the literature on the determinants of merger success, provide new evidence on the impact of corporate culture, and offer a new approach to defining firms’ cultural similarity.
New onset of depression in aging women and men: contributions of social, psychological, behavioral, and somatic predictors in the community
Authors: Beutel Manfred E. , Brähler Elmar , Wiltink Joerg , Kerahrodi Jasmin Ghaemi , Burghardt Juliane , Michal Matthias , Schulz Andreas , Wild Phillipp S. , Münzel Thomas , Schmidtmann Irene , Lackner Karl J. , Pfeiffer Norbert , Borta Andreas , Tibubos Ana N.
Published: August 2018

Background

Based on the vulnerability–stress model, we aimed to (1) determine new onset of depression in individuals who had not shown evidence of depression at baseline (5 years earlier) and (2) identify social, psychological, behavioral, and somatic predictors.

Methods

Longitudinal data ofN= 10 036 participants (40–79 years) were evaluated who had no evidence of depression at baseline based on Patient Health Questionnaire (PHQ-9), no history of depression, or intake of antidepressants. Multivariate logistic regression models were used to predict the onset of depression.

Results

Prevalence of new cases of depression was 4.4%. Higher rates of women (5.1%) than men (3.8%) were due to their excess incidence <60 years of age. Regression analyses revealed significant social, psychological, behavioral, and somatic predictors: loneliness [odds ratio (OR) 2.01; 95% confidence interval (CI) 1.48–2.71], generalized anxiety (OR 2.65; 1.79–3.85), social phobia (OR 1.87; 1.34–2.57), panic (OR 1.67; 1.01–2.64), type D personality (OR 1.85; 1.47–2.32), smoking (OR 1.35; 1.05–1.71), and comorbid cancer (OR 1.58; 1.09–2.24). Protective factors were age (OR 0.88; 0.83–0.93) and social support (OR 0.93; 0.90–0.95). Stratified by sex, cancer was predictive for women; for men smoking and life events. Entered additionally, the PHQ-9 baseline score was strongly predictive (OR 1.40; 1.34–1.47), generalized anxiety became only marginally, and panic was no longer predictive. Other predictors remained significant, albeit weaker.

Conclusions

Psychobiological vulnerability, stress, and illness-related factors were predictive of new onset of depression, whereas social support was protective. Baseline subclinical depression was an additional risk weakening the relationship between anxiety and depression by taking their overlap into account. Vulnerability factors differed between men and women.
-SPECTRUM OF SELF-SIMILAR MEASURES WITH OVERLAPS IN THE ABSENCE OF SECOND-ORDER IDENTITIES
Authors: NGAI SZE-MAN , XIE YUANYUAN
Published: August 2018

For the class of self-similar measures in $\mathbb{R}^{d}$ with overlaps that are essentially of finite type, we set up a framework for deriving a closed formula for the $L^{q}$-spectrum of the measure for $q\geq 0$. This framework allows us to include iterated function systems that have different contraction ratios and those in higher dimension. For self-similar measures with overlaps, closed formulas for the $L^{q}$-spectrum have only been obtained earlier for measures satisfying Strichartz’s second-order identities. We illustrate how to use our results to prove the differentiability of the $L^{q}$-spectrum, obtain the multifractal dimension spectrum, and compute the Hausdorff dimension of the measure.
COORDINATISING PLANES OF PRIME POWER ORDER USING FINITE FIELDS
Authors: COULTER ROBERT S.
Published: August 2018

We revisit the coordinatisation method for projective planes by considering the consequences of using finite fields to coordinatise projective planes of prime power order. This leads to some general restrictions on the form of the resulting planar ternary ring (PTR) when viewed as a trivariate polynomial over the field. We also consider how the Lenz–Barlotti type of the plane being coordinatised impacts the form of the PTR polynomial, thereby deriving further restrictions.
Twins Switched at Birth: Frequency, Life Histories, Twin Relationships, and Critical Issues/Twin Research Reviews: Classroom Placement; Mirror Syndrome; Unusual Twinning; Parenting Stress/Human Interest: Triplet Film; Educational Achievement; Prison Release; Co-Twin Impersonation; Facial Recognition Technology
Authors: Segal Nancy L.
Published: August 2018

Twins switched at birth are a rare subtype of twins who grow up apart. The frequency with which this event occurs, as well as selected life history events, twin relationships, and critical issues generated by the nine recorded cases are reviewed. This is followed by summaries of recent studies addressing classroom placement for twins, mirror syndrome in mothers, unusual twin types, and parenting stress. The article concludes with a review of human interest items from the general media, namely a triplet film, educational achievement, prison release, co-twin impersonation, and facial recognition technology.
On the positive association between candy and fruit gum consumption and hyperactivity in children and adolescents with ADHD
Authors: Wolff Nicole , Reimelt Charlotte , Ehrlich Stefan , Hölling Heike , Mogwitz Sabine , Roessner Veit
Published: August 2018

Abstract. Objective: The purpose of the present study was the analysis of the association between consumption of candy and fruit gums, diagnosis of attention deficit hyperactivity disorder (ADHD), and behavioural problems. Methods: In total, 1,187 children and adolescents of the German Health Interview and Examination Survey for Children and Adolescents (KiGGS) were analyzed. Results: It was observed that children and adolescents with ADHD as compared to healthy controls (HC) reported to consume more frequently and higher amounts of candy and fruit gums and that hyperactivity was associated with frequent candy and fruit gum consumption. Conclusions: Because with the present design no conclusions on causality or directionality of the found associations could be drawn, results are discussed quite broadly in the light of several previously published interpretations, also to serve as a generator for further research. One more innovative speculation is that children and adolescents with ADHD may consume more frequently candy and fruit gums in order i) to compensate for their higher needs of energy resulting from hyperactive behaviour and/or ii) to compensate for the ADHD-typical deficits in the “reward cascade”.
A New Empirical Model of the Subauroral Polarization Stream
Authors: Kunduri B. S. R. , Baker J. B. H. , Ruohoniemi J. M. , Nishitani N. , Oksavik K. , Erickson P. J. , Coster A. J. , Shepherd S. G. , Bristow W. A. , Miller E. S.
Published: August 2018

Regions of persistent westward directed flows are often observed equatorward of the auroral oval in the dusk‐midnight sector. In general, the midnight narrow flows are termed as subauroral ion drifts and the duskside broader flows are termed subauroral polarization streams (SAPS). SAPS/subauroral ion drift electric fields play an important role in controlling the dynamics of the midlatitude ionosphere. In this paper we analyze longitudinally extended observations of SAPS measured by midlatitude Super Dual Auroral Radar Network (SuperDARN) radars under varied geomagnetic conditions. We find that SAPS speeds exhibit a strong dependence on geomagnetic activity, with flows exceeding 1,500 m/s during geomagnetic storms and dropping to 100 m/s during periods of geomagnetic quiet. Moreover, SAPS flows turn increasingly poleward when moving from the midnight sector toward dusk and this effect is more pronounced during disturbed geomagnetic conditions. The variations in SAPS speeds with magnetic local time (MLT) are also found to be strongly dependent on geomagnetic conditions. Specifically, SAPS speeds increase quasilinearly with MLT during disturbed geomagnetic conditions, whereas during relatively quiet geomagnetic conditions there is no discernible trend. This behavior suggests the possibility of different mechanisms influencing SAPS during geomagnetically quiet conditions. Average cross‐SAPS potentials increase with geomagnetic activity and typically vary between 15 and 45 kV. Finally, a new empirical model of SAPS potentials has been developed parameterized by Asy‐H index, MLT, and magnetic latitude.
Variability of Suspended Particle Properties Using Optical Measurements Within the Columbia River Estuary
Authors: Tao Jing , Hill Paul S. , Boss Emmanuel S. , Milligan Timothy G.
Published: August 2018

Optical properties are used to understand the spatial and temporal variability of particle properties and distribution within the Columbia River Estuary, especially in the salinity transition zone and in the estuarine turbidity maximum region. Observations of optical properties in the Columbia River Estuary are consistent with the established model that the river water brings more organic, smaller particles into the estuary, where they flocculate and settle into the salt wedge seaward of the density front. Large tidal currents resuspend mineral‐rich, larger aggregates from the seabed, which accumulate at the density front. Optical proxies for particle size (beam attenuation exponent γ and backscattering exponent γbb) are compared to conventional measurements. The γ and γbb are different to the expected trend with Sauter mean diameter Ds of suspended particles from low‐ to medium‐salinity waters (LMW). Ds increases in the LMW as does the γ derived from a WET Labs ac‐9, which indicates that the particle population dominating the ac‐9 is decreasing in size. The most likely explanation is that flocculation acting at LMW transfers mass preferentially from medium‐sized particles to large‐sized particles that are out of the size range to which the ac‐9 is most sensitive; γbb shows no trend in the LMW. Since γbb is a proxy of proportion of fine particles versus large flocs, the variation of γbb may be insensitive to changes in the medium‐sized particles. The overall results demonstrate that γbb is a reliable proxy for changes in particle size in a stratified environment.
Vertical Profiles of Tropospheric Ozone From MAX‐DOAS Measurements During the CINDI‐2 Campaign: Part 1—Development of a New Retrieval Algorithm
Authors: Wang Yang , Puķīte Janis , Wagner Thomas , Donner Sebastian , Beirle Steffen , Hilboll Andreas , Vrekoussis Mihalis , Richter Andreas , Apituley Arnoud , Piters Ankie , Allaart Marc , Eskes Henk , Frumau Arnoud , Van Roozendael Michel , Lampel Johannes , Platt Ulrich , Schmitt Stefan , Swart Daan , Vonk Jan
Published: August 2018

Ground‐based measurements of tropospheric ozone (O3) are valuable for studies of atmospheric chemistry, air pollution, climate change, and for satellite validation. The Multi Axis Differential Optical Absorption Spectroscopy (MAX‐DOAS) technique has been widely used to derive vertical profiles of trace gases and aerosols in the troposphere. However, tropospheric O3 has not yet been satisfactorily derived from MAX‐DOAS measurements due to the influence of stratospheric O3 absorption. In this study, we developed two new retrieval approaches for tropospheric O3 from MAX‐DOAS measurements. In method 1, stratospheric O3 profiles from external data sources are considered in the retrieval. In method 2, stratospheric and tropospheric O3 are separated based on the temperature‐dependent differences between tropospheric and stratospheric O3 absorption structures in the UV spectral range. The feasibility of both methods is first verified by applying them to synthetic spectra. Then they are applied to real MAX‐DOAS measurements recorded during the CINDI‐2 campaign in Cabauw, the Netherlands (September 2016). The obtained results are compared with independent O3 measurements and global chemical transport model simulations. Good agreement of the near‐surface O3 concentrations with the independent data sets is found for both methods. However, tropospheric O3 profiles are only reasonably derived using method 1, while they are significantly overestimated at altitudes above 1 km using method 2, probably due to the approximation of the ring spectra used to correct the rotational Raman scattering structures in the DOAS fit. Advantages and disadvantages of both methods are discussed and improvement directions are suggested for further studies.
Parameterization of In‐Cloud Aerosol Scavenging Due to Atmospheric Ionization: Part 3. Effects of Varying Droplet Radius
Authors: Zhang Liang , Tinsley Brian A. , Zhou Limin
Published: August 2018

A new set of simulations of collision rate coefficients for aerosol particles with droplets (in‐cloud scavenging) extends to a droplet radius of 15 μm, with short‐range effects on collisions treated as an increment of droplet effective collision radius (ECR). The simulations are made with our Monte Carlo trajectory model for midtropospheric (~5 km) conditions. The use of ECR allows the results to be expressed as a modified analytic solution (MAS) for the rate coefficients, incorporating both long‐range and short‐range effects. For smaller particles with radius less than 0.2 μm, the increment of ECR is only caused by the particle charge inducing a short‐range image electric force, and results of the MAS match quite well that of our trajectory model. For larger particles, the short‐range effects become complex, including particle size effects (weight, intercept, and flow around the particle), with image forces induced by both droplet and particle charges. An ECR based on these factors gives average errors between the MAS and the trajectory model of less than 10%, with smaller errors for larger droplets. We have now completed the parameterizations of rate coefficients for midtropospheric conditions that can be applied to cloud models. One application would be to test whether electrically induced changes in scavenging rates, which have been proposed to significantly affect cloud processes dependent on condensation nucleus concentration and contact ice nucleation, can explain observed cloud responses to changes in current flow in the global electric circuit.
Mercury Hollows as Remnants of Original Bedrock Materials and Devolatilization Processes: A Spectral Clustering and Geomorphological Analysis
Authors: Lucchetti A. , Pajola M. , Galluzzi V. , Giacomini L. , Carli C. , Cremonese G. , Marzo G. A. , Ferrari S. , Massironi M. , Palumbo P.
Published: August 2018

We perform a detailed geomorphological and compositional analysis on three craters hosting hollows located in the Victoria and Kuiper Quadrangles of Mercury. Based on Mercury Dual Imaging System data, high‐resolution detailed geomorphological mapping is provided in order to fully characterize the geological framework where hollows formed. In addition, we apply an unsupervised spectral clustering, based on a K‐mean algorithm, to separate in clusters our data sets. The comparison between the spectral and the well‐defined geomorphological units reveals a spatially coherent distribution. In particular, all hollows are uniquely identified by a well‐defined spectrum showing a wide absorption band between 0.558 and 0.828, with a possible hint of absorption toward 1 μm. Our analysis suggests that the composition of hollows may be characterized by a mixture of different minerals contributing to the absorptions found in our spectra. Indeed, sulfides alone (CaS, MnS, and MgS) cannot explain the spectrum behavior of hollows, even if the mechanism forming hollows likely involves the loss of volatiles from the surface. Hence, we have to consider bedrock‐forming material as partial responsible of the absorptions. For the studied hollows we suggest that the bedrock‐forming minerals are pyroxenes presenting transitional elements, like Cr, Ti, and Ni in substitution of Mg and/or Fe. Therefore, we suggest that the spectral characteristics of hollows are related to both remnant material produced by devolatilization process and to bedrock in which the hollows formed.
Convergence of evidence from a methylome-wide CpG-SNP association study and GWAS of major depressive disorder
Authors: Aberg Karolina A. , Shabalin Andrey A. , Chan Robin F. , Zhao Min , Kumar Gaurav , van Grootheest Gerard , Clark Shaunna L. , Xie Lin Y. , Milaneschi Yuri , Penninx Brenda W. J. H. , van den Oord Edwin J. C. G.
Published: August 2018

DNA methylation is an epigenetic modification that provides stability and diversity to the cellular phenotype. It is influenced by both genetic sequence variation and environmental factors, and can therefore potentially account for variation of heritable phenotypes and disorders. Therefore, methylome-wide association studies (MWAS) are promising complements to genome-wide association studies (GWAS) of genetic variants. Of particular interest are methylation sites (CpGs) that are created or destroyed by the alleles of single-nucleotide polymorphisms (SNPs), as these so-called CpG-SNPs may show variation in methylation levels on top of what can be explained by the sequence variation. Using sequencing-based data from 1132 major depressive disorder (MDD) cases and controls, we performed a MWAS of 970,414 common CpG-SNPs. The analysis identified 27 suggestively significant (P < 1.00 × 10−5) CpG-SNPs associations. Furthermore, the MWAS results were over-represented (odds ratios ranging 1.36–5.00; P ranging 4.9 × 10−3–8.1 × 10−2) among findings from three recent GWAS for MDD-related phenotypes. Overlapping loci included, e.g., ROBO2, ASIC2, and DCC. As the CpG-SNP analysis accounts for the number of alleles that creates CpGs, the methylation differences could not be explained by differences in allele frequencies. Thus, the results show that the MWAS and GWASs provide independent lines of evidence for the involvement of these loci in MDD. In conclusion, our methylation study of MDD contributes novel information about loci of relevance that complements previous findings and generates new hypothesis about MDD etiology, such as that the functional effects of genetic association may be partly mediated and/or enhanced by the methylation status in these loci.
The biological significance of histone modifiers in multiple myeloma: clinical applications
Authors: Ohguchi Hiroto , Hideshima Teru , Anderson Kenneth C.
Published: August 2018

Multiple myeloma (MM) is a clonal plasma cell disorder that is characterized by a variety of genetic alterations. Recent studies have highlighted not only the importance of these genetic events but also epigenetic aberrations including DNA methylation, histone modifications, and non-coding RNAs in the biology of MM. Post-translational modifications of histone, such as methylation and acetylation, contribute to chromatin dynamics, and are modulated by histone modifying enzymes, and dysregulation of these enzymes is implicated in the pathogenesis of cancers, including MM. Histone modifiers also have non-histone substrates and enzymatically independent roles, which are also involved in tumorigenesis. Here we review and provide comprehensive insight into the biologic significance of histone methyl- and acetyl-modifiers in MM, and further provide an overview of the clinical applications of histone modifier inhibitors, especially histone deacetylase inhibitors. These findings underline the emerging roles of histone modifiers in the pathogenesis of MM, and further highlight the possibility of novel epigenetic therapies in MM.
Self-decoupled radiofrequency coils for magnetic resonance imaging
Authors: Yan Xinqiang , Gore John C. , Grissom William A.
Published: August 2018

Arrays of radiofrequency coils are widely used in magnetic resonance imaging to achieve high signal-to-noise ratios and flexible volume coverage, to accelerate scans using parallel reception, and to mitigate field non-uniformity using parallel transmission. However, conventional coil arrays require complex decoupling technologies to reduce electromagnetic coupling between coil elements, which would otherwise amplify noise and limit transmitted power. Here we report a novel self-decoupled RF coil design with a simple structure that requires only an intentional redistribution of electrical impedances around the length of the coil loop. We show that self-decoupled coils achieve high inter-coil isolation between adjacent and non-adjacent elements of loop arrays and mixed arrays of loops and dipoles. Self-decoupled coils are also robust to coil separation, making them attractive for size-adjustable and flexible coil arrays.
Author Correction: Scalable high-precision tuning of photonic resonators by resonant cavity-enhanced photoelectrochemical etching
Authors: Gil-Santos Eduardo , Baker Christopher , Lemaître Aristide , Ducci Sara , Gomez Carmen , Leo Giuseppe , Favero Ivan
Published: August 2018

The original version of this Article omitted the fourth author, Sara Ducci from Matériaux et Phénomènes Quantiques, Université Paris Diderot, CNRS UMR 7162, Sorbonne Paris-Cité, 10 rue Alice Domon et Léonie Duquet, Paris 75013, France. This mistake has been corrected in both the HTML and PDF versions of the Article.
Psychophysical reverse correlation reflects both sensory and decision-making processes
Authors: Okazawa Gouki , Sha Long , Purcell Braden A. , Kiani Roozbeh
Published: August 2018

Goal-directed behavior depends on both sensory mechanisms that gather information from the outside world and decision-making mechanisms that select appropriate behavior based on that sensory information. Psychophysical reverse correlation is commonly used to quantify how fluctuations of sensory stimuli influence behavior and is generally believed to uncover the spatiotemporal weighting functions of sensory processes. Here we show that reverse correlations also reflect decision-making processes and can deviate significantly from the true sensory filters. Specifically, changes of decision bound and mechanisms of evidence integration systematically alter psychophysical reverse correlations. Similarly, trial-to-trial variability of sensory and motor delays and decision times causes systematic distortions in psychophysical kernels that should not be attributed to sensory mechanisms. We show that ignoring details of the decision-making process results in misinterpretation of reverse correlations, but proper use of these details turns reverse correlation into a powerful method for studying both sensory and decision-making mechanisms.
Lower-crustal earthquakes in southern Tibet are linked to eclogitization of dry metastable granulite
Authors: Shi Feng , Wang Yanbin , Yu Tony , Zhu Lupei , Zhang Junfeng , Wen Jianguo , Gasc Julien , Incel Sarah , Schubnel Alexandre , Li Ziyu , Chen Tao , Liu Wenlong , Prakapenka Vitali , Jin Zhenmin
Published: August 2018

Southern Tibet is the most active orogenic region on Earth where the Indian Plate thrusts under Eurasia, pushing the seismic discontinuity between the crust and the mantle to an unusual depth of ~80 km. Numerous earthquakes occur in the lower portion of this thickened continental crust, but the triggering mechanisms remain enigmatic. Here we show that dry granulite rocks, the dominant constituent of the subducted Indian crust, become brittle when deformed under conditions corresponding to the eclogite stability field. Microfractures propagate dynamically, producing acoustic emission, a laboratory analog of earthquakes, leading to macroscopic faults. Failed specimens are characterized by weak reaction bands consisting of nanometric products of the metamorphic reaction. Assisted by brittle intra-granular ruptures, the reaction bands develop into shear bands which self-organize to form macroscopic Riedel-like fault zones. These results provide a viable mechanism for deep seismicity with additional constraints on orogenic processes in Tibet.
Investigation of Novel Regulation of N-myristoyltransferase by Mammalian Target of Rapamycin in Breast Cancer Cells
Authors: Jacquier Marine , Kuriakose Shiby , Bhardwaj Apurva , Zhang Yang , Shrivastav Anuraag , Portet Stéphanie , Varma Shrivastav Shailly
Published: August 2018

Breast cancer is the most common cancer in women worldwide. Hormone receptor breast cancers are the most common ones and, about 2 out of every 3 cases of breast cancer are estrogen receptor (ER) positive. Selective ER modulators, such as tamoxifen, are the first line of endocrine treatment of breast cancer. Despite the expression of hormone receptors some patients develop tamoxifen resistance and 50% present de novo tamoxifen resistance. Recently, we have demonstrated that activated mammalian target of rapamycin (mTOR) is positively associated with overall survival and recurrence free survival in ER positive breast cancer patients who were later treated with tamoxifen. Since altered expression of protein kinase B (PKB)/Akt in breast cancer cells affect N-myristoyltransferase 1 (NMT1) expression and activity, we investigated whether mTOR, a downstream target of PKB/Akt, regulates NMT1 in ER positive breast cancer cells (MCF7 cells). We inhibited mTOR by treating MCF7 cells with rapamycin and observed that the expression of NMT1 increased with rapamycin treatment over the period of time with a concomitant decrease in mTOR phosphorylation. We further employed mathematical modelling to investigate hitherto not known relationship of mTOR with NMT1. We report here for the first time a collection of models and data validating regulation of NMT1 by mTOR.
Integrating optical coherence tomography with gravimetric and video analysis (OCT-Gravimetry-Video method) for studying the drying process of polystyrene latex system
Authors: Huang Hao , Huang Yongyang , Lau Willie , Ou-Yang H. Daniel , Zhou Chao , El-Aasser Mohamed S.
Published: August 2018

Latex, an aqueous dispersion of sub-micron polymer particles, is widely used as polymer binder in waterborne coatings and adhesives. Drying of a latex is inhomogeneous, during which the spatial distribution of particles is non-uniform and changes with time, usually resulting in a compromise of the integrity of a dried film. To study drying inhomogeneity of latex, we developed a system integrating optical coherence tomography (OCT) with gravimetric and video analysis (OCT-Gravimetry-Video method) to non-destructively monitor the drying process of non-film-forming latexes consisting of hard polystyrene spheres over time. OCT structural and speckle images of the latex’s internal structure show the packing process of particles, the detachment of latex and the formation of apparent shear bands in cross-sectional views. Video recordings show the formation of cracks and the propagation of the drying boundary in the horizontal direction. The drying curve, measured by gravimetry, shows the drying rate and the water content of the latex at each drying stage. Furthermore, we find that the particle size affects packing and cracking phenomena remarkably. The OCT-Gravimetry-Video method serves as a general and robust approach to investigate the drying process of waterborne latex system. This method can be employed for fundamental studies of colloids and for evaluations of industrial latex products.
Corneal myofibroblasts inhibit regenerating nerves during wound healing
Authors: Jeon Kye-Im , Hindman Holly B. , Bubel Tracy , McDaniel Thurma , DeMagistris Margaret , Callan Christine , Huxlin Krystel R.
Published: August 2018

Abnormal nerve regeneration often follows corneal injury, predisposing patients to pain, dry eye and vision loss. Yet, we lack a mechanistic understanding of this process. A key event in corneal wounds is the differentiation of keratocytes into fibroblasts and scar-forming myofibroblasts. Here, we show for the first time that regenerating nerves avoid corneal regions populated by myofibroblasts in vivo. Recreating this interaction in vitro, we find neurite outgrowth delayed when myofibroblasts but not fibroblasts, are co-cultured with sensory neurons. After neurites elongated sufficiently, contact inhibition was observed with myofibroblasts, but not fibroblasts. Reduced neurite outgrowth in vitro appeared mediated by transforming growth factor beta 1 (TGF-β1) secreted by myofibroblasts, which increased phosphorylation of collapsin response mediating protein 2 (CRMP2) in neurons. The significance of this mechanism was further tested by applying Mitomycin C after photorefractive keratectomy to decrease myofibroblast differentiation. This generated earlier repopulation of the ablation zone by intra-epithelial and sub-basal nerves. Our findings suggest that attaining proper, rapid corneal nerve regeneration after injury may require blocking myofibroblast differentiation and/or TGF-β during wound healing. They also highlight hitherto undefined myofibroblast-neuron signaling processes capable of restricting neurite outgrowth in the cornea and other tissues where scars and nerves co-exist.
Bony pseudoteeth of extinct pelagic birds (Aves, Odontopterygiformes) formed through a response of bone cells to tooth-specific epithelial signals under unique conditions
Authors: Louchart Antoine , Buffrénil Vivian de , Bourdon Estelle , Dumont Maïtena , Viriot Laurent , Sire Jean-Yves
Published: August 2018

Modern birds (crown group birds, called Neornithes) are toothless; however, the extinct neornithine Odontopterygiformes possessed bone excrescences (pseudoteeth) which resembled teeth, distributed sequentially by size along jaws. The origin of pseudoteeth is enigmatic, but based on recent evidence, including microanatomical and histological analyses, we propose that conserved odontogenetic pathways most probably regulated the development of pseudodentition. The delayed pseudoteeth growth and epithelium keratinization allowed for the existence of a temporal window during which competent osteoblasts could respond to oral epithelial signaling, in place of the no longer present odontoblasts; thus, bony pseudoteeth developed instead of true teeth. Dynamic morphogenetic fields can explain the particular, sequential size distribution of pseudoteeth along the jaws of these birds. Hence, this appears as a new kind of deep homology, by which ancient odontogenetic developmental processes would have controlled the evolution of pseudodentition, structurally different from a true dentition, but morphologically and functionally similar.