bluuebunny/crossref_metadata_2025 huggingface dataset:
Efficient community detection in multilayer networks using boolean compositions
Authors: Santra Abhishek , Irany Fariba Afrin , Madduri Kamesh , Chakravarthy Sharma , Bhowmick Sanjukta
Published: August 2023

Networks (or graphs) are used to model the dyadic relations between entities in complex systems. Analyzing the properties of the networks reveal important characteristics of the underlying system. However, in many disciplines, including social sciences, bioinformatics, and technological systems, multiple relations exist between entities. In such cases, a simple graph is not sufficient to model these multiple relations, and a multilayer network is a more appropriate model. In this paper, we explore community detection in multilayer networks. Specifically, we propose a novel network decoupling strategy for efficiently combining the communities in the different layers using the Boolean primitives AND, OR, and NOT. Our proposed method, network decoupling, is based on analyzing the communities in each network layer individually and then aggregating the analysis results. We (i) describe our network decoupling algorithms for finding communities, (ii) present how network decoupling can be used to express different types of communities in multilayer networks, and (iii) demonstrate the effectiveness of using network decoupling for detecting communities in real-world and synthetic data sets. Compared to other algorithms for detecting communities in multilayer networks, our proposed network decoupling method requires significantly lower computation time while producing results of high accuracy. Based on these results, we anticipate that our proposed network decoupling technique will enable a more detailed analysis of multilayer networks in an efficient manner.
Global trends and current status in pheochromocytoma: a bibliometric analysis of publications in the last 20 years
Authors: Huang Bi-ling , Liu Qi , Teng Yuan-yuan , Peng Shu-qin , Liu Ze , Li Ming-liu , Liang Jie-yu , Zhang Yi , Wang Min
Published: August 2023

Objective

Pheochromocytoma is a rare catecholamine-producing neuroendocrine tumour originating from the chromaffin cells of the adrenal medulla or extra-adrenal paraganglia. However, there are few bibliometric studies on Pheochromocytoma. Therefore, this study was employed to summarize the global trends and current status in pheochromocytoma by bibliometric analysis.

Materials and methods

The Web of Science (WOS) core collection database was searched for publications relating to pheochromocytoma from 2001 to 2021. Bibliometric analysis was used to examine the data, and Microsoft Excel was utilized to create bar graphs. In addition, VOSviewer was used to carry out co-authorship analysis, co-citation analysis and co-occurrence analysis. CiteSpace was used to analyze the keywords citation bursts.

Results

A total of 8,653 publications published in 1,806 journals by 38,590 authors in 6,117 organizations from 100 countries/regions were included in our study. Among them, USA was the leading countries in terms of total publications and sum of time cited, whereas Eunice Kennedy Shriver Natl Inst Child Hlth & Hum was the leading institutions. The main publications for pheochromocytoma-related articles were Journal of clinical endocrinology &metabolism. Pacak karel and Eisenhofer Graeme were the main contributing authors. The studies on pheochromocytoma could be grouped into five clusters: Treatment, Mechanism, Etiology, Radiology and Hormones study. Moreover, the radiology study, etiology study and some specific keywords such germlines mutation, mesenchymal stem-cells, autophagy, neuroinflammation, neurotoxicity, and hemodynamic instability, may become the hot spots of future.

Conclusion

Although the number of articles on pheochromocytoma has fluctuated slightly over the past 20 years, there has been an overall upward trend. In general, precision medicine research on pheochromocytoma, especially metastatic pheochromocytoma, in terms of diagnosis, treatment, and etiology will be a hot research topic in the future. This study helps to understand the research perspectives, hot spots and trends of pheochromocytoma and provide new insight and a basis for future pheochromocytoma research quickly.
More than tears: associations between exposure to chemical agents used by law enforcement and adverse reproductive health outcomes
Authors: Hassan Asha , Ojanen-Goldsmith Alison , Hing Anna K. , Mahoney Madeline , Traxler Sarah , Boraas Christy M.
Published: August 2023

Despite routine law enforcement use of chemical agents for crowd control, the reproductive health safety profiles of these products are unknown. Moreover, limited evidence has documented a link between such exposures and adverse reproductive health outcomes including abnormal uterine bleeding and potential pregnancy disruption. This cross-sectional study examined reproductive outcomes in adults with uteri exposed to chemical agents used by law enforcement, more commonly known as “tear gas”. Participants were recruited through social media in the wake of police violence protests. Of the 1,276 participants included in analysis, 83% reported experiencing at least one of the outcomes of interest, included uterine cramping (69%), early menstrual bleeding (55%), breast tenderness (30%), and delayed menstrual bleeding (19%). Chemical agent exposure was significantly associated with higher odds of an adverse reproductive health outcome, those with 5 days or more of exposure have 2.6 times the odds (CI: 1.61, 4.22) of adverse outcomes and having a perception that one's menstruation may fluctuate according to psychosocial stressors was associated (OR = 1.94, CI: 1.36, 2.79) with a higher odds of an adverse reproductive health experience. These findings suggest a potential relationship between exposure to chemical agents and adverse reproductive health outcomes. Given the pervasive use of these chemical agents and their potential for reproductive health harm, further investigation into the safety of these products and their impacts on individual and community health is warranted urgently.
Spatial and temporal distribution characteristics and prediction analysis of nitrogen and phosphorus surface source pollution in Shandong Province under the climate and land use changes
Authors: Li Qingsong , Zhang Jincai , Zhang Jiawen , Gao Huishan , Chen Weiqiang , Huang Junchang , Guo Yulong , Yue Shuaijun , Li Genming
Published: August 2023

The aim of this study was to explore the characteristics of non-point source pollution of nitrogen (N) and phosphorus (P) under the background of climate and land use in Shandong Province. First, using the InVEST NDR module in the model, N and P non-point source pollution in 2010 and 2020 in Shandong Province were simulated; then, based on precipitation data under three different global climate models (MRI-ESM-0, GFDL-ESM4, and Ec-Earth3) and two Shared Socioeconomic Pathways (SSP245 and SSP585), land use data under two Shared Socioeconomic Pathways (SSP245 and SSP585) were used to simulate and predict the non-point source pollution of N and P in Shandong Province in 2030. The results showed the following: (1) On the time scale, the output load and total output of N and P decreased during 2010–2020, while the output load and total output of N and P increased during 2020–2030. (2) On the spatial scale, the spatial distribution of N and P output loads in 2010, 2020, and 2030 is roughly the same, being “low in the northwest and high in the southeast”. (3) Different climate scenarios have a great influence on N and P output load and total output, and the N and P pollution in the SSP585 scenario is more serious. The total output of N and P did not change much in different climate models, while the spatial distribution of the output load of N and P varied significantly, indicating that different climate models had a greater impact on the spatial distribution of the output load of N and P. (4) The overall cold hot spot pattern of nitrogen and phosphorus pollution in Shandong Province is stable, basically showing a “band + cluster + scatter” distribution pattern; the hot spot area in the central and southern region of Shandong Province changes little regardless of the model, the northwest is basically a cold spot area, and the nitrogen and phosphorus hot spot area under the SSP245 scenario in Ec-Earth3 model had the least amount of change. According to research results, combined with the actual situation of Shandong Province, it is hoped that it can provide theoretical basis for the prevention and control of non-point source pollution in Shandong Province in the future.
CO2 emissions in the Amazon: are bottom-up estimates from land use and cover datasets consistent with top-down estimates based on atmospheric measurements?
Authors: Tejada Graciela , Gatti Luciana V. , Basso Luana S. , Cassol Henrique L. G. , Silva-Junior Celso H. L. , Mataveli Guilherme , Marani Luciano , Arai Egidio , Gloor Manuel , Miller John B. , Cunha Camilla L. , Domingues Lucas G. , Ipia Alber , Correia Caio S. C. , Crispim Stephane P. , Neves Raiane A. L. , Von Randow Celso
Published: August 2023

Amazon forests are the largest forests in the tropics and play a fundamental role for regional and global ecosystem service provision. However, they are under threat primarily from deforestation. Amazonia's carbon balance trend reflects the condition of its forests. There are different approaches to estimate large-scale carbon balances, including top-down (e.g., CO2 atmospheric measurements combined with atmospheric transport information) and bottom-up (e.g., land use and cover change (LUCC) data based on remote sensing methods). It is important to understand their similarities and differences. Here we provide bottom-up LUCC estimates and determine to what extent they are consistent with recent top-down flux estimates during 2010 to 2018 for the Brazilian Amazon. We combine LUCC datasets resulting in annual LUCC maps from 2010 to 2018 with emissions and removals for each LUCC, and compare the resulting CO2 estimates with top-down estimates based on atmospheric measurements. We take into account forest carbon stock maps for estimating loss processes, and carbon uptake of regenerating and mature forests. In the bottom-up approach total CO2 emissions (2010 to 2018), deforestation and degradation are the largest contributing processes accounting for 58% (4.3 PgCO2) and 37% (2.7 PgCO2) respectively. Looking at the total carbon uptake, primary forests play a dominant role accounting for 79% (−5.9 PgCO2) and secondary forest growth for 17% (−1.2 PgCO2). Overall, according to our bottom-up estimates the Brazilian Amazon is a carbon sink until 2014 and a source from 2015 to 2018. In contrast according to the top-down approach the Brazilian Amazon is a source during the entire period. Both approaches estimate largest emissions in 2016. During the period where flux signs are the same (2015–2018) top-down estimates are approximately 3 times larger in 2015–2016 than bottom-up estimates while in 2017–2018 there is closer agreement. There is some agreement between the approaches–notably that the Brazilian Amazon has been a source during 2015–2018 however there are also disagreements. Generally, emissions estimated by the bottom-up approach tend to be lower. Understanding the differences will help improve both approaches and our understanding of the Amazon carbon cycle under human pressure and climate change.
Decidualized human decidual stromal cells inhibit chemotaxis of activated T cells: a potential mechanism of maternal-fetal immune tolerance
Authors: Llorca Tatiana , Ruiz-Magaña Maria Jose , Martinez-Aguilar Rocio , García-Valdeavero Olga María , Rodríguez-Doña Lucia , Abadia-Molina Ana Clara , Ruiz-Ruiz Carmen , Olivares Enrique G.
Published: August 2023

Background

Numerous lines of evidence confirm that decidual stromal cells (DSCs) play a key role in maternal–fetal immune tolerance. Under the influence of progesterone and other hormones, the DSCs go through a process of differentiation (decidualization) during normal pregnancy. In mice, DSCs inhibit the expression of chemokines that attract abortigenic Th1 and Tc cells to the decidua. We have studied this phenomenon in humans.

Methods

We established human DSC lines and decidualized these cells in vitro with progesterone and cAMP. We determined the expression of the chemokines CXCL9, CXCL10 and CXCL11, whose receptor CXCR3 is expressed by Th1 and Tc cells, in undifferentiated DSCs and decidualized DSCs by qRT-PCR. Activated CD3+CXCR3+ cells, including CD4+ Th1 cells and CD8+ Tc cells, were induced in vitro. The migration capacity of these activated lymphocytes was investigated in Transwell chambers with conditioned media from undifferentiated and decidualized DSCs.

Results

We demonstrated that CXCL9 was not expressed by DSCs, whereas the expression of CXCL10 and CXCL11 was inhibited in decidualized cells. Conditioned media from decidualized cells significantly inhibited the migration of Th1 and Tc cells. We found that decidualized cells secrete factors of MW less than 6000–8000 Da, which actively inhibit the chemotaxis of these lymphocytes.

Discussion

These results confirm in humans that decidualization of DSCs inhibits the expression by these cells of chemokines that attract Th1 and Tc cells and induces the secretion by DSCs of factors that inhibit the chemotaxis of these lymphocytes, thus preventing the arrival of abortigenic T cells in the decidua.
A comparison of the burden of knee osteoarthritis attributable to high body mass index in China and globally from 1990 to 2019
Authors: Song Min , Chen Huijing , Li Jingyi , Han Weichang , Wu Wenfeng , Wu Gaoyi , Zhao Anqi , Yuan Qing , Yu Jiani
Published: August 2023

Background

Excess body mass index (BMI) plays a key role in the onset and progression of knee osteoarthritis (knee OA). However, the burden of knee OA attributable to high BMI at the global, Chinese, and regional levels have received far too little attention. The aim of this study is to provide evidence to support the design of policy by investigating long-term trends of years lived with disability (YLDs) for knee OA.

Methods

To illustrate the trends of YLDs for knee OA attributable to high BMI and the temporal trends of the YLDs rate by age, period, and cohort, Joinpoint regression software and age-period-cohort (APC) were used to analyze the YLDs data of knee OA from the Global Burden of Disease (GBD) 2019.

Results

In China, there were 549,963.5 YLDs for knee OA attributable to high BMI in 2019, which had increased by 460.7% since 1990. From 1990 to 2019, age-standardized disability-adjusted life year rate (ASDR) of knee OA attributable to high BMI trended upwards. The average annual percent change (AAPC) of knee OA attributable to high BMI in China and globe were 3.019, 1.419%, respectively. The longitudinal age curve of the APC model showed that the YLDs rates of knee OA due to high BMI increased with age, and YLDs rates were higher among females than males. The period rate ratios (RRs) of knee OA due to high BMI increased significantly. The cohort RRs of knee OA due to high BMI increased among those born between 1900 and 1970. The net drifts of knee OA attributable to high BMI in China and globe were above 1. Compared with global condition, the net drift values of knee OA attributable to high BMI in China was higher. Compared with females, males had higher net drift value. Countries with high socio-demographic index (SDI) have a much higher burden of knee OA caused by high BMI than countries with low SDI.

Conclusion

In China, high BMI is a substantial cause of knee OA, the incidence of which has been increasing since 1990. In addition, women and the elderly are more vulnerable to knee OA caused by high BMI. The Chinese government must take the long-term impact of high BMI on knee OA into account and implement effective public health policies and resort to interventions to reduce the burden as soon as possible.
Building a predictive model for assessing the risk of Salmonella shedding at slaughter in fattening pigs
Authors: Bernad-Roche María , Marín-Alcalá Clara María , Cebollada-Solanas Alberto , de Blas Ignacio , Mainar-Jaime Raúl Carlos
Published: August 2023

Salmonellosis continues to be a major cause of foodborne outbreaks worldwide, and pigs are one of the main sources of human infection. Salmonella pork contamination is a major concern for abattoirs and is related to the presence of Salmonella in pigs' feces at slaughter. Being able to predict the risk of Salmonella shedding in pigs arriving at the slaughterhouse could help mitigate abattoir and carcass contamination. For this purpose, 30 batches of 50 pigs each were selected from 30 different fattening units. The pigs were tagged and bled for the detection of antibodies against Salmonella approximately one month before slaughter. Pooled floor fecal samples were also collected from 10 pens per unit for Salmonella detection, and a questionnaire on biosecurity was administered to each farm. At the abattoir, colon content was collected from each tagged pig for the Salmonella shedding assessment. A predictive model for Salmonella shedding at slaughter was built with two-third of the pigs by employing random-effects logistic regression analysis, with Salmonella shedding as the dependent variable and pig serology and other farm/environmental characteristics as the independent variables. The model included farm as the grouping factor. Data from the remaining one-third of the pigs were used for model validation. Out of 1,500 pigs initially selected, 1,341 were identified at the abattoir and analyzed. Salmonella was detected in 13 (43.3%; 95%CI = 27.4–60.8) of the fattening units. The mean batch seroprevalence (cut-off OD% ≥40) among the fattening units was 31.7% (95%CI = 21.8–41.0), and a total of 316 pigs (23.6%; 95%CI = 21.4–25.9) shed Salmonella at slaughter. The model predicted reasonably well (Area under the curve = 0.76; P < 0.05) whether a pig would shed Salmonella at slaughter, with estimates of sensitivity and specificity at 71.6% and 73.6%, respectively. Serology, the percentage of Salmonella-positive pens on the farm, and the internal biosecurity score were significantly associated (P < 0.05) with Salmonella shedding at the abattoir, and several scenarios were observed by the model. The study highlighted that although serology may be helpful for identifying batches of pigs at risk of shedding Salmonella upon their arrival at the abattoir, it may not be necessary in some scenarios.
Non-invasive EEG-based BCI spellers from the beginning to today: a mini-review
Authors: Maslova Olga , Komarova Yuliya , Shusharina Natalia , Kolsanov Alexander , Zakharov Alexander , Garina Evgenia , Pyatin Vasiliy
Published: August 2023

The defeat of the central motor neuron leads to the motor disorders. Patients lose the ability to control voluntary muscles, for example, of the upper limbs, which introduces a fundamental dissonance in the possibility of daily use of a computer or smartphone. As a result, the patients lose the ability to communicate with other people. The article presents the most popular paradigms used in the brain-computer-interface speller system and designed for typing by people with severe forms of the movement disorders. Brain-computer interfaces (BCIs) have emerged as a promising technology for individuals with communication impairments. BCI-spellers are systems that enable users to spell words by selecting letters on a computer screen using their brain activity. There are three main types of BCI-spellers: P300, motor imagery (MI), and steady-state visual evoked potential (SSVEP). However, each type has its own limitations, which has led to the development of hybrid BCI-spellers that combine the strengths of multiple types. Hybrid BCI-spellers can improve accuracy and reduce the training period required for users to become proficient. Overall, hybrid BCI-spellers have the potential to improve communication for individuals with impairments by combining the strengths of multiple types of BCI-spellers. In conclusion, BCI-spellers are a promising technology for individuals with communication impairments. P300, MI, and SSVEP are the three main types of BCI-spellers, each with their own advantages and limitations. Further research is needed to improve the accuracy and usability of BCI-spellers and to explore their potential applications in other areas such as gaming and virtual reality.
Low host immune pressure may be associated with the development of hepatocellular carcinoma: a longitudinal analysis of complete genomes of the HBV 1762T, 1764A mutant
Authors: Jiang Zhi-Hua , Chen Qin-Yan , Jia Hui-Hua , Wang Xue-Yan , Zhang Lu-Juan , Huang Xiao-Qian , Harrison Tim J. , Jackson J. Brooks , Wu Li , Fang Zhong-Liao
Published: August 2023

Background

It has been reported that hepatitis B virus (HBV) double mutations (A1762T, G1764A) are an aetiological factor of hepatocellular carcinoma (HCC). However, it is unclear who is prone to develop HCC, among those infected with the mutant. Exploring HBV quasispecies, which are strongly influenced by host immune pressure, may provide more information about the association of viral factors and HCC.

Materials and methods

Nine HCC cases and 10 controls were selected from the Long An cohort. Serum samples were collected in 2004 and 2019 from subjects with HBV double mutations and the complete genome of HBV was amplified and sequenced using next-generation sequencing (NGS).

Results

The Shannon entropy values increased from 2004 to 2019 in most cases and controls. There was no significant difference in mean intrahost quasispecies genetic distances between cases and controls. The change in the values of mean intrahost quasispecies genetic distances of the controls between 2004 and 2019 was significantly higher than that of the cases (P<0.05). The viral loads did not differ significantly between cases and controls in 2004(p=0.086) but differed at diagnosed in 2019 (p=0.009). Three mutations occurring with increasing frequency from 2004 to 2019 were identified in the HCC cases, including nt446 C→G, nt514 A→C and nt2857T→C. Their frequency differed significantly between the cases and controls (P<0.05).

Conclusions

The change in the values of mean intrahost quasispecies genetic distances in HCC was smaller, suggesting that HBV in HCC cases may be subject to low host immune pressure. Increasing viral loads during long-term infection are associated with the development of HCC. The novel mutations may increase the risk for HCC.
A contrast-enhanced CT-based radiomic nomogram for the differential diagnosis of intravenous leiomyomatosis and uterine leiomyoma
Authors: Shao Jiang , Wang Chaonan , Shu Keqiang , Zhou Yan , Cheng Ninghai , Lai Zhichao , Li Kang , Xu Leyin , Chen Junye , Du Fenghe , Yu Xiaoxi , Zhu Zhan , Wang Jiaxian , Feng Yuyao , Yang Yixuan , Liu Xiaolong , Yuan Jinghui , Liu Bao
Published: August 2023

Objective

Uterine intravenous leiomyomatosis (IVL) is a rare and unique leiomyoma that is difficult to surgery due to its ability to extend into intra- and extra-uterine vasculature. And it is difficult to differentiate from uterine leiomyoma (LM) by conventional CT scanning, which results in a large number of missed diagnoses. This study aimed to evaluate the utility of a contrast-enhanced CT-based radiomic nomogram for preoperative differentiation of IVL and LM.

Methods

124 patients (37 IVL and 87 LM) were retrospectively enrolled in the study. Radiomic features were extracted from contrast-enhanced CT before surgery. Clinical, radiomic, and combined models were developed using LightGBM (Light Gradient Boosting Machine) algorithm to differentiate IVL and LM. The clinical and radiomic signatures were integrated into a nomogram. The diagnostic performance of the models was evaluated using the area under the curve (AUC) and decision curve analysis (DCA).

Results

Clinical factors, such as symptoms, menopausal status, age, and selected imaging features, were found to have significant correlations with the differential diagnosis of IVL and LM. A total of 108 radiomic features were extracted from contrast-enhanced CT images and selected for analysis. 29 radiomics features were selected to establish the Rad-score. A clinical model was developed to discriminate IVL and LM (AUC=0.826). Radiomic models were used to effectively differentiate IVL and LM (AUC=0.980). This radiological nomogram combined the Rad-score with independent clinical factors showed better differentiation efficiency than the clinical model (AUC=0.985, p=0.046).

Conclusion

This study provides evidence for the utility of a radiomic nomogram integrating clinical and radiomic signatures for differentiating IVL and LM with improved diagnostic accuracy. The nomogram may be useful in clinical decision-making and provide recommendations for clinical treatment.
Risk and diagnostic factors and therapy outcome of neonatal early onset sepsis in ICU patients of Saudi Arabia: a systematic review and meta analysis
Authors: Alshammari Mohammed K. , Alsanad Ahlam H. , Alnusayri Rawan J. , Alanazi Abdulmajeed S. , Shamakhi Fatmah Q. , Alshahrani Khaled M. , Alshahrani Abdullah M. , Yahya Ghaliah , Alshahrani Abdulaziz A. , Alshahrani Turki S. , Sultan Hamad S. , Alshahrani Fatimah M. , Alreshidi Fouzyia A. , Alnigaidan Renad A. , Almazyad Abdulaziz A.
Published: August 2023

Background

Neonatal early onset sepsis (NEOS) is a serious and potentially life-threatening condition affecting newborns within the first few days of life. While the diagnosis of NEOS was based on clinical signs and symptoms in the past, recent years have seen growing interest in identifying specific diagnostic factors and optimizing therapy outcomes. This study aims to investigate the diagnostic and risk factors and therapy outcomes of neonatal EOS in ICU patients in Saudi Arabia, with the goal of improving the management of neonatal EOS in the country.

Methods

This method outlines the protocol development, search strategy, study selection, and data collection process for a systematic review on neonatal early onset sepsis in Saudi Arabian ICU patients, following the PRISMA 2020 guidelines. PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) is a well-established guideline that provides a framework for conducting systematic reviews and meta-analyses in a transparent and standardized manner. It aims to improve the quality and reporting of such research by ensuring clear and comprehensive reporting of study methods, results, and interpretations. The search strategy included electronic databases (PubMed, Embase, Google Scholar, Science Direct, and the Cochrane Library) and manual search of relevant studies, and data were extracted using a standardized form.

Results

The systematic review included 21 studies on neonatal sepsis in Saudi Arabia, with varying study designs, sample sizes, and prevalence rates of sepsis. Group B streptococcus and E. coli were the most commonly isolated pathogens. Various diagnostic factors and risk factors were reported, including hematological parameters, biomarkers, and blood cultures. The quality of the included studies was assessed using the Newcastle-Ottawa Scale and Joanna Briggs Institute critical checklist.

Conclusions

The review identified a number of risk and diagnostic factors and therapy outcomes for neonatal sepsis. However, most of the studies were having small scale cohort groups. Further research with controlled study designs is needed to develop effective prevention and management strategies for neonatal sepsis in Saudi Arabia.
Exosomes: potential diagnostic markers and drug carriers for adenomyosis
Authors: Cheng Wen-Xiu , Wei Shao-Bin , Zhou Yang , Shao Yu , Li Mao-Ya
Published: August 2023

Adenomyosis is a common benign gynecological disorder and an important factor leading to infertility in fertile women. Adenomyosis can cause deep lesions and is persistent and refractory in nature due to its tumor-like biological characteristics, such as the ability to implant, adhere, and invade. The pathogenesis of adenomyosis is currently unclear. Therefore, new therapeutic approaches are urgently required. Exosomes are nanoscale vesicles secreted by cells that carry proteins, genetic materials and other biologically active components. Exosomes play an important role in maintaining tissue homeostasis and regulating immune responses and metabolism. A growing body of work has shown that exosomes and their contents are key to the development and progression of adenomyosis. This review discusses the current research progress, future prospects and challenges in this emerging therapeutic tool by providing an overview of the changes in the adenomyosis uterine microenvironment and the biogenesis and functions of exosomes, with particular emphasis on the role of exosomes and their contents in the regulation of cell migration, proliferation, fibrosis formation, neovascularization, and inflammatory responses in adenomyosis.
Thermodynamic modelling of mixtures of water, carbon dioxide and hydrogen at high pressure and temperature for hydrothermal CO2 reduction processes
Authors: Navarro-Cárdenas Iván , Martín Ángel
Published: August 2023

In the context of the increasing CO2 emissions and the corresponding environmental problems, CO2 utilization processes that transform CO2 into valuable compounds rather than just capturing and storing it can contribute to the transition to a carbon-free economy, giving value to unavoidable CO2 emissions. Among the different technologies studied, hydrothermal conversion stands out by the high yields achieved in comparatively short reaction times and by the possibility to scale-up the process. The hydrothermal conversion uses CO2 dissolved in aqueous solutions as feedstock, in which bicarbonate is the reacting species. Therefore, knowledge of the equilibrium concentrations of dissolved species is of interest for the development of the process. In this work, a thermodynamic model based on the activity coefficient model developed by Pitzer, Sun and Duan model is implemented and solved. The influence of different process conditions: temperature, pressure, composition of the initial solution, on the equilibrium composition of the dissolution is analyzed with the model. Experimental results obtained in hydrothermal reduction experiments are thus interpreted with the aid of the model. It is observed that the process is favored by moderate temperatures (<500 K), high initial concentrations of sodium bicarbonate (up to 2 mol/kg) and moderate initial concentrations of sodium hydroxide (below 1.5 mol/kg).
Cardiorespiratory fitness and development of childhood cardiovascular risk: The EXAMIN YOUTH follow-up study
Authors: Hauser Christoph , Lichtenstein Eric , Nebiker Lukas , Streese Lukas , Köchli Sabrina , Infanger Denis , Faude Oliver , Hanssen Henner
Published: August 2023

Background: Obesity- and hypertension-related cardiovascular (CV) risk has been shown to originate in childhood. Higher body mass index (BMI) and blood pressure (BP) have been associated with increased large artery stiffness and a lower microvascular arteriolar-to-venular diameter ratio (AVR) in children. This study aimed to investigate the association of cardiorespiratory fitness (CRF) with development of BMI, BP and vascular health during childhood.

Methods: In our prospective cohort study, 1,171 children aged 6–8 years were screened for CRF, BMI, BP, retinal vessel diameters and pulse wave velocity using standardized protocols. Endurance capacity was assessed by 20 m shuttle run test. After 4 years, all parameters were assessed in 664 children using the same protocols.

Results: Children with a higher CRF at baseline developed a significantly lower BMI (β [95% CI] −0.09 [−0.11 to −0.06] kg/m2, p < 0.001), a lower systolic BP (β [95% CI] −0.09 [−0.15 to −0.03] mmHg, p = 0.004) and a higher AVR (β [95% CI] 0.0004 [0.00004 to 0.0007] units, p = 0.027) after 4 years. The indirect association of CRF with development of retinal arteriolar diameters was mediated by changes in BMI.

Conclusion: Our results identify CRF as a key modulator for the risk trajectories of BMI, BP and microvascular health in children. Obesity-related CV risk has been shown to track into adulthood, and achieving higher CRF levels in children may help counteract the development of CV risk and disease not only in pediatric populations, but may also help reduce the burden of CVD in adulthood.

Registration:http://www.clinicaltrials.gov/ (NCT02853747).
The prospects and challenges of Kosovo's accession to the EU in light of the EU's policies and priorities
Authors: Mexhuani Burim
Published: August 2023

Introduction

This paper analyzes the extent to which the EU's involvement in Kosovo's political and economic development has contributed to the country's progress toward democratization and European integration.

Methods

The study employs a comparative analysis of the EU's engagement with Kosovo versus other Western Balkan countries. It also utilizes a case study approach to identify the unique challenges presented by Kosovo's contested statehood. Data sources include official EU reports, agreements, commentary from experts, and economic indicators.

Results

The findings show the EU has played a pivotal role in Kosovo through deploying its assistance instruments, facilitating the normalization dialogue with Serbia, and laying out a potential accession path. However, non-recognition by five member states, disputes with Serbia, and struggles meeting EU reform criteria impact Kosovo's integration prospects.

Discussion

Despite its substantial involvement, the EU faces credibility issues in Kosovo due to ongoing hurdles thwarting Kosovo's advancement toward accession. The EU must increase its leverage over Serbia, incentivize internal reforms, and align member state positions to support Kosovo's European integration. A clearer pathway to membership in Kosovo would reinforce the EU's role in fostering peace, democracy, and prosperity in the Western Balkans.
Social control and self-control: factors linking exposure to domestic violence and adolescents’ Internet gaming addiction
Authors: Quancai Li , Meng Cui , Kunjie Cui
Published: August 2023

Although many studies have investigated the influencing factors of adolescents’ Internet gaming addiction, few have investigated the influence factor of exposure to domestic violence, and even fewer have used the General Strain Theory to explain the influence path of exposure to domestic violence on adolescents’ Internet gaming addiction. Based on the GST, this study sought to uncover further insights into the effect of exposure to family violence on adolescents’ Internet gaming addiction, and the mediating role of social control—specifically, parental attachment—and self-control in the association between exposure to family violence and adolescents’ Internet gaming addiction. Adopting a multi-stage cluster random sampling method, we conducted this study with 2,110 adolescents from Liangshan Yi Autonomous Prefecture in Sichuan Province, China. The results suggest that adolescents’ exposure to domestic violence directly affects their addiction to Internet games and indirectly affects it by decreasing social control and self-control. The study not only supplements and improves the explanatory framework of General Strain Theory, but makes a significant contribution to research on the causes of Internet gaming addiction.
Informal settlements and the care of children 0–3 years of age: a qualitative study
Authors: Jegathesan Thivia , Yousafzai Aisha , Mantel Michaela , Sereni Vittorio , Armstrong Robert W. , Minhas Ripudaman Singh
Published: August 2023

Background

There is a rapid increase in urbanization with a high percentage of people living in poverty in urban informal settlements. These families, including single parents, are requiring accessible and affordable childcare. In Mlolongo, an informal settlement in Machakos County in Nairobi metropolitan area, Kenya, childcare centres, referred to as ‘babycares’ are increasing in number. They are being provided by local community members without attention to standards or quality control. The study objective was to understand parents’, caregivers’ and community elders’ experiences and perceptions in terms of the quality of babycares in Mlolongo to inform the design and implementation of improved early childcare services.

Methods

Using a community-based participatory research philosophy, a qualitative study including focus group discussions with parents, community elders and babycare centre employees/owners (referred to as caregivers) was conducted in Mlolongo.

Results

A total of 13 caregivers, 13 parents of children attending babycares, and eight community elders participated in the focus groups. Overall, community elders, parents and caregivers felt that the babycares were not providing an appropriate quality of childcare. The reported issues included lack of training and resources for caregivers, miscommunication between parents and caregivers on expectations and inappropriate child to caregiver ratio.

Conclusion

The deficiencies identified by respondents indicate a need for improved quality of affordable childcare to support early child development in these settings. Efforts need to be invested in defining effective models of early childcare that can meet the expectations and needs of parents and caregivers and address the major challenges in childcare quality identified in this study.
How Does the Brain Allow the Eyes to See?
Authors: Kim Soo Hyun , Cho Eun Ji , Kim Yu Jin , Kim Song E. , Lee Hyang Woon
Published: August 2023

Did you know that it is not only your eyes that allow you to see? Your brain functions with the eyes to process and make sense of all things that you see. A part of the brain called the visual cortex is responsible for vision. The brain contains over 100 billion brain cells called neurons, and they work in “levels” to help you see the world—from a basic level in which you perceive simple shapes up to higher levels where you understand complex patterns. When networks of brain neurons do not work properly, brain disorders can result. Doctors and scientists can use various techniques to measure the activity of neurons. For example, unusual patterns of brain waves can tell us about damaged neural networks and brain abnormalities. Computers can also be programmed to “see” visual information, and such computers can help us to learn about the vision process in humans.
Evaluation of cardiac indices using M-mode echocardiography after administration of metoclopramide and ondansetron in donkeys (Equus asinus): an experimental study
Authors: Marzok Mohamed , Kandeel Mahmoud , Alkhodair Khaled , Abdel-Raheem Sherief , Ismail Hisham , Farag Alshimaa , Ibrahim Hossam , El-Ashkar Maged , Shousha Saad , El-Khodery Sabry
Published: August 2023

The aim of the present study was to evaluate cardiac indices using M-mode echocardiography after the administration of metoclopramide and ondansetron in donkeys. For this purpose, 10 apparently healthy Egyptian Baladi donkeys (Equus asinus) were used in a crossover prospective study. Two trials were conducted with the administration of metoclopramide hydrochloride anhydrous at a dose of 0.25 mg Kg−1 and ondansetron hydrochloride sodium at a dose of 0.15 mg Kg−1. The control group (placebo) received a total volume of 50 mL of isotonic saline at 0.9%. An echocardiographic examination was performed using a Digital Color Doppler Ultrasound System equipped with a 2–3.9 MHz phased array sector scanner transducer. In general, the fractional shortening (FS%) was significantly affected by the time for metoclopramide (p = 0.031) and ondansetron (p = 0.047) compared with those of placebo, with treatment with metoclopramide provoking significantly higher percentages of FS% at T60 (p = 0.009) and T90 (p = 0.028) compared with those for ondansetron and placebo. The interaction of time x treatment also showed a statistically significant alteration of FS% (p < 0.05), while the values returned to the basal line at T240. Metoclopramide induced a significant decrease in E-point to septal separation (EPSS) at T90 (p = 0.005), and T240 (p = 0.007) compared with ondansetron and placebo. The time x treatment interaction also showed a significant (p < 0.05) variation in EPSS, with values returning to the basal line at T300. Mitral valve opening velocity (DE SLP) values were significantly affected by time (p = 0.004) in the metoclopramide group compared with those of ondansetron and placebo. Administration of metoclopramide and ondansetron provoked significant alterations of DE SLP at T60 (p = 0.039), T120 (p = 0.036), and T300 (p = 0.005) compared with placebo. In conclusion, caution should be exercised when administering both treatments, especially to animals with suspected cardiac problems.
Comparison of patellofemoral contact pressure after semi-cylindrical recession trochleoplasty and trochlear block recession in feline cadavers
Authors: Choi Goda , Kang Jinsu , Kim Namsoo , Heo Suyoung
Published: August 2023

Introduction

The purpose of this study was to compare the changes in the patellofemoral joint (PFJ) contact mechanisms of the normal state, trochlear hypoplasia model and after performing trochleoplasty on the hypoplasia model in feline cadavers.

Methods

Twenty normal pelvic limbs were acquired from the 10 feline cadavers. First, the PFJ contact mechanisms were measured in normal state, then trochlear hypoplasia models were created using customized trochlear ridge cutting guides. After measuring PFJ contact mechanisms in the trochlear hypoplasia models, they were divided into two groups and performed semi-cylindrical recession trochleoplasty (SCRT) and trochlear block recession (TBR) were performed, respectively. After that, the PFJ contact mechanisms were measured and the values of the 4 groups (normal state, trochlear hypoplasia, SCRT, TBR) were compared.

Results

The trochlear hypoplasia group showed increased contact pressure and decreased contact areas compared to the normal state group. In the groups that underwent tracheoplasty (SCRT and TBR), PFJ contact mechanisms were recovered similarly to that of the normal state group. The PFJ of the SCRP group was measured similar to that of the normal group than that of the TBR group.

Discussion

Tracheoplasty can be useful in restoring PFJ contact mechanisms and SCRT can be considered as a good alternative to the conventional methods of trochleoplasty.
Recency, Frequency, Monetary Value, Clustering, and Internal and External Indices for Customer Segmentation from Retail Data
Authors: Wilbert Henrique José , Hoppe Aurélio Faustino , Sartori Andreza , Stefenon Stefano Frizzo , Silva Luís Augusto
Published: August 2023

While there are several ways to identify customer behaviors, few extract this value from information already in a database, much less extract relevant characteristics. This paper presents the development of a prototype using the recency, frequency, and monetary attributes for customer segmentation of a retail database. For this purpose, the standard K-means, K-medoids, and MiniBatch K-means were evaluated. The standard K-means clustering algorithm was more appropriate for data clustering than other algorithms as it remained stable until solutions with six clusters. The evaluation of the clusters’ quality was obtained through the internal validation indexes Silhouette, Calinski Harabasz, and Davies Bouldin. When consensus was not obtained, three external validation indexes were applied: global stability, stability per cluster, and segment-level stability across solutions. Six customer segments were obtained, identified by their unique behavior: lost customers, disinterested customers, recent customers, less recent customers, loyal customers, and best customers. Their behavior was evidenced and analyzed, indicating trends and preferences. The proposed method combining recency, frequency, monetary value (RFM), K-means clustering, internal indices, and external indices achieved return rates of 17.50%, indicating acceptable selectivity of the customers.
Variable Scale Pruning for Transformer Model Compression in End-to-End Speech Recognition
Authors: Ben Letaifa Leila , Rouas Jean-Luc
Published: August 2023

Transformer models are being increasingly used in end-to-end speech recognition systems for their performance. However, their substantial size poses challenges for deploying them in real-world applications. These models heavily rely on attention and feedforward layers, with the latter containing a vast number of parameters that significantly contribute to the model’s memory footprint. Consequently, it becomes pertinent to consider pruning these layers to reduce the model’s size. In this article, our primary focus is on the feedforward layers. We conduct a comprehensive analysis of their parameter count and distribution. Specifically, we examine the weight distribution within each layer and observe how the weight values progress across the transformer model’s blocks. Our findings demonstrate a correlation between the depth of the feedforward layers and the magnitude of their weights. Consequently, layers with higher weight values require less pruning. Building upon this insight, we propose a novel pruning algorithm based on variable rates. This approach sets the pruning rate according to the significance and location of each feedforward layer within the network. To evaluate our new pruning method, we conduct experiments on various datasets. The results reveal its superiority over conventional pruning techniques, such as local pruning and global pruning.
Optimal Collaborative Scheduling of Multi-Aircraft Types for Forest Fires General Aviation Rescue
Authors: Pan Weijun , Huang Yuanjing , Yin Zirui , Qin Liru
Published: August 2023

The scheduling of rescue aircraft needs to be studied in depth because of its criticality for the general aviation rescue of forest fires. This paper constructs a collaborative schedule optimization model for general aviation rescue under the condition of multiple aircraft, from multiple rally points to multiple fire points, targeting the shortest rescue time and the lowest rescue cost in the context of forest fires based on the simulation verification of a forest fire that broke out simultaneously in multiple locations in Liangshan Prefecture, Sichuan Province, China. The Non-dominated Sorting Genetic Algorithm II (NSGA-II) algorithm was used to find the optimal set of solutions satisfying the objective function: four feasible solutions. Then, the optimal solution was solved based on the weighted TOPSIS method, which was the optimal solution for this rescue task. The simulation results show that unnecessary flight times can be reduced by optimizing the schedule plan. Under the premise of ensuring rescue timeliness, the utilization rate of rescue aircraft was improved, and rescue costs were further reduced. The presented work provides a theoretical reference for the efficient development of general aviation rescue.