bluuebunny/crossref_metadata_2025 huggingface dataset:
Effect of Non-Fulfillment of Assumptions on Gage Repeatability and Reproducibility Study Evaluation
Authors: Klaput Pavel , Vykydal David , Plura Jiří
Published: October 2019

The evaluation of the measurement system quality has already become an integral part of quality planning activities in both the automotive and metallurgical industries. An important assumption for obtaining the most relia ble results is compliance with the basic assumptions for evaluating the variability of the measurement system. The main goal of this paper is to analyze, how the failure to meet the basic assumptions influences the evaluation of the measurement system's statistical properties. This goal is achieved by performing a detailed analysis of the latest developments in the field of measurement systems analysis aimed at verifying the assumptions of normality and uniformity. The evaluation of the effect of non-fulfillment of both assumptions on the values of the most important statistical properties of the measurement system is performed using simulated data. Suitable graphical tools are used for practical verification of both assumptions.
Quality Index of Multi-Disc Grinding Process of Grainy Biomass
Authors: Kruszelnicka Weronika , Idzikowski Adam , Markowska Katarzyna , Kasner Robert
Published: October 2019

The main aim of the grinding process is size reduction. For such formulated purpose of grinding, the particles dimensions after grinding process are the major quality determinant indicated in many works concerning size reduction. In this paper original quality index integrating size reduction and energy consumption in the grinding process was proposed. The aim of the study is to create method for grinding process quality assessment. The problem was formulated as a question: (1) is it possible to create mathematical description of grinding process quality? (2) what grinding parameters influence on the grinding quality index? To resolve the problem, original quality index was developed and experiment on a multi-disc mill was conducted. On the basis of obtained results it was found that discs angular speed affects the grinding process quality.
Improvement of Manual Assembly Line Based on Value Stream Mapping (VSM) and Efectiveness Coefficient
Authors: Klimecka-Tatar Dorota , Shinde Vishvajit
Published: October 2019

In the paper the possibilities of process re-organizing in relation to simple principles for limiting waste in the production cycle have been presented. Based on value stream mapping and monitoring of performance indicators, the possibilities of changes identification of in the assembly line process have been presented. Furthermore, based on the availability, performance and quality values, it has been proved that relatively small changes can have a very positive effect on the assembly process. Based on the OEE coefficient, it has been found that the proposed changes improved the process's efficiency by more than 20%.
Analysis and Improvement of the Galvanized Wire Production Process with the use of DMAIC Cycle
Authors: Knop Krzysztof
Published: October 2019

The article presents the results in the scope of analysis and improvement of the galvanized wire production process with the use of Six Sigma's DMAIC cycle. The basic problem was identified - incorrect wire diameters after galvanizing and specific tools and methods were used to analyze this problem and look for its solution. The potential of Pareto analysis, SPC method, control plan, 5WHY analysis was used. As a result of the analyzes carried out, the source cause was identified - contaminated containers dispensing the preparation maintaining the temperature in the galvanizing unit. To eliminate the problem, maintenance of the machine used to cover the bare wire with zinc was carried out, which allowed to achieve the following results: standstills at the Drawing and Galvanizing Department were eliminated, the duration of the manufacturing process and the percentage of products beyond the specification were significantly reduced.
Concept of Reconfigurability in Interoperation Manufacturing Buffers for Smart Factory
Authors: Grznár Patrik , Mozol Štefan , Vavrík Vladimír , Gabajová Gabriela , Furmannová Beáta
Published: October 2019

In this article, it is described how the reconfigurable inter-operational buffers system built on the Digital Twin platform. Interoperating production buffers are now widely used in production. Their effect on the production system can be seen in decreasing downtime. From a cost-based point of view, the interoperating production buffers may generate a gain from the reduction in the volume of work-in-process, with which we increase production performance. This ratio depends on the average number of products that the buffers contain. The average number of pieces in the buffer is limited by the capacity of the buffer. The impact of turbulence in production is seen precisely on the average content of inter-operational production buffers. If we want to maintain work-in-process on optimal values, it is necessary to calculate and maintain the optimal capacity of each interoperating production buffer on the line. In the context of Smart Factory, it is currently possible that the current capacity of the interoperating production buffers is maintained according to the current state of production. In the subject system, real production facilities communicate with each other through the IoT as autonomous agents, which are decided on the basis of a formula to calculate the optimal capacity of the buffers, the prediction of faults and negotiation, thus actively maintaining the optimal capacity of intermediate operating production buffers for Smart Factory support.
Effects of ketosis in dairy cows on blood biochemical parameters, milk yield and composition, and digestive capacity
Authors: Yang Wei , Zhang Bingbing , Xu Chuang , Zhang Hongyou , Xia Cheng
Published: October 2019

Introduction

This study aimed to characterise the effects of ketosis on milk yield and composition and digestive capacity in transition dairy cows.

Material and Methods

Seven ketotic and seven healthy cows were housed in individual stalls for six days. Samples of plasma, milk, refused total mixed ration, and faeces were collected, and the blood biochemical parameters, milk yield and composition, dry matter intake, and faecal dry matter (FDM) production were determined.

Results

Compared with healthy cows, the ketotic cows had significantly higher concentrations of milk fat and citrate, but lower levels of milk protein and lactose. The cows exhibited a need for acid detergent fibre in forage and better digestion of neutral detergent fibre, starch, crude protein, and phosphorus than healthy cows, but more fat and gross energy were excreted in their faeces. Ketotic cows had higher energy-corrected milk yields and lower FDM than healthy cows.

Conclusion

Lower feed intake coinciding with the requirement to maintain high milk production is considered to be the cause of ketosis in dairy cows. Ketotic cows exhibited lower dry matter fat digestion.
Where the geographical expanse ends – Space education in primary school. Implementation of inquiry based science education (IBSE) in geography lessons in Polish school
Authors: Sypniewski Jakub
Published: October 2019

Inquiry based science education has been more and more popular strategy in teaching sciences in recent years. Transregional pressure put by international, standardized knowledge and skills tests (e.g. PISA) to converge curricula (Rundgren 2015) of different European states paradoxically helps to promote the open inquiry method which involves the student in the teaching process. Earlier research done in many countries such as Turkey, Israel, Sweden, The Czech Republic (Heinz et al. 2017), Ireland (Dunne et al. 2013) or The Netherlands (Uum van Martina et al. 2016) shows the increase of interest in IBSE both in Europe and in the world.

Teaching geography in Polish primary schools follows international educational trends. This study analyses several proposals of educational activities connected with Space which support geography teaching. All of them are conducted with using open inquiry method, which is recommended in New National Curriculum of geography (Core Curriculum, 2017, Geography-classes V-VIII).
Profil Pemahaman Konseptual Mahasiswa Calon Guru Matematika tentang Grup Ditinjau dari Kemampuan Matematika
Authors: Faizah Hanim
Published: October 2019

Many students have not mastered the concept of group theory well. Hence, the researcher intended to describe the conceptual understanding of group theory based on the student’s mathematical abilities. The implementation of this research begun with the students studied about Group Theory classically. Next, to examine the mathematical abilities of students, the researcher administered the questionnaire to obtain the data about the GPA (Grade Point Average) of students. Then, the researcher chose the participants of this study based on the high, middle, and low GPA. The selected research subjects were then given test questions that had been validated by the experts. Data was analyzed using the indicators of conceptual understanding, namely: (1) explaining or restate the group concept, (2) providing an example and a nonexample, (3) using group concept to solve the problem. The results showed that the students with high mathematical abilities reached three indicators of conceptual understanding perfectly. Students with medium mathematical abilities reached two indicators of conceptual understanding but it was not perfect, she did not write the answer completely. In addition, students with low mathematical abilities could not do the test at all, he could not write the group correctly. He did not reach any indicators of conceptual understanding, thus, it can be concluded that the students with low mathematical abilities did not understand the concept well.
Implementation of Data Warehouse in Human Resource Information System Using SEM-GeSCA
Authors: Anshari Muhammad , Suryadharma I Putu , Rinas I Wayan
Published: October 2019

Today, the changing nature of work and organization that occurs is quite high, causing the organization to be under pressure to adapt to changing circumstances. Work becomes more dynamic, making proactive behavior seen as a critical determinant of an organization's success. The purpose of this study was to identify the effect of HR practices on proactive behavior, as well as the role of mediation of work attachment to the relationship. Hypothesis testing using Generalized Structured Component Analysis model. From the test results found that the attachment of work plays a role in mediating the influence of work attachment to partial mediation behavior (Partial mediation). Limitations This study is using cross sectional data, a specific type of company and does not use data discriminately. This study uses dimensional integration to test proactive behavior that is directly influenced by HR practices and indirectly mediated by work attachment.
Implementation of Data Mining To Predict Period of Students Study Using Naive Bayes Algorithm
Authors: Peling Ida Bagus Adisimakrisna , Arnawan I Nyoman , Arthawan I Putu Arich , Janardana I Gusti Ngurah
Published: October 2019

The quality of universities, especially study programs in Indonesia is measured based on accreditation conducted by BAN PT. According to BAN PT the quality is measured based on 7 main standards, one of them is Student and Graduate. One of the problems that still be the subject of discussion related to student failure is about the students who graduated not on time. Students graduating not on time are students who can not complete their studies in accordance with the provisions of time given. The existence of a graduate student is not timely of course cause problems and potentially drop out that affect the quality of education and accreditation. A system that predicts students' graduation is required by evaluating their learning outcomes. The timeliness of graduating students can be done with data mining techniques to find graduation patterns of students who have graduated which then used as a basis to predict students' graduation in the next year. This study showed that Naïve Bayes was able to classify the correct data testing on average by 86.16% and 13.84% error. In addition, other information obtained from the data testing used that the students who entered from the PMDK Pass graduated on time as much as 40%, other paths graduated on time by 26.7%, and pass filter exam on time 13.3%.
Hypothyroid Symptoms in Levothyroxine-Treated Patients
Authors: Freeman Maisha , Adunlin Georges A. , Mercadel Candice , Danzi Sara , Klein Irwin
Published: October 2019

Purpose: Approximately 15% of patients with hypothyroidism are dissatisfied with their treatment due to persistence of residual symptoms associated with hypothyroidism.  The purpose of this study was to compare thyroid symptoms using the hypothyroid symptom scale (HSS) in patients receiving stable thyroid therapy for 6 months to patients without hypothyroidism.  The HSS was used to identify the percentage of levothyroxine-treated hypothyroid patients with residual or persistent hypothyroid symptoms.

Methods:  Patients included in the study had hypothyroidism and were receiving a stable/maintenance dose of levothyroxine sodium therapy, unchanged for at least 6 months.  A control group of patients were included if they did not have an active prescription for thyroid hormone therapy.  The HSS was administered via phone or face-to-face interactions.   Patients were asked to score 10 symptoms over the past month on a scale of 0 to 4 (e.g., 0, absence of, to 4, severe symptoms).  Results were analyzed using descriptive and inferential statistics.  T-tests and chi-squared analysis were used to assess differences in continuous and categorical variables.

Results:  A total of 68% of the contacted patients responded to the survey.  A total of 302 patients were in the intervention group and 273 were in the control group.  The mean total HSS scores between groups were significantly higher in the treatment compared to the control group (13.92 ± 10.91 vs.10.07 ± 7.85; P < 0.001).

Conclusion: Significantly more patients receiving thyroid hormone therapy experienced residual thyroid symptoms compared to control patients.  Attempts should be made to offer alternatives for hypothyroid patients with persistent symptoms.

 

Article Type: Original Research
La transparencia como principio vertebrador de la contratación pública: significado y problemas de articulación normativa
Authors: González Ríos Isabel
Published: October 2019

El objeto de este trabajo es delimitar y concretar el significado del término transparencia aplicado a la contratación pública y despejar las dudas que plantea el sistema de fuentes con incidencia en la materia (la ley de contratos del sector público, la legislación de transparencia de 2013 y la ley de procedimiento administrativo común), proponiendo una interpretación integrada del mismo.

El concepto de transparencia en materia de contratación pública deriva de su configuración en el derecho de la Unión Europea como principio abstracto que favorece la buena gobernanza y la participación ciudadana, y que se orienta a lograr el mercado único. Pero su plasmación a nivel interno en varias normas con rango de ley exige clarificar las obligaciones que conlleva y su régimen de control, eliminando confusiones de articulación normativa.
La protección del denunciante: regulación autonómica actual, novedades normativas y propuestas de futuro
Authors: Garrido Juncal Andrea
Published: October 2019

Este trabajo plantea una reflexión sobre la figura del denunciante. No se trata ahora de ahondar en si este reúne o no la condición de interesado en el procedimiento sancionador, ni tampoco de reabrir el debate de en qué medida este estaría legitimado para impugnar una resolución, puesto que ambas cuestiones, aunque sean de permanente interés, ya han sido estudiadas por la doctrina. En la actualidad parece que se pretende impulsar un pacto entre los ciudadanos y los poderes públicos dirigido a conseguir el máximo respeto posible por la legalidad, ofreciendo a los primeros protección. Varias Comunidades Autónomas han legislado recientemente con el cometido de superar las reticencias a denunciar, la Unión Europea acaba de presentar también una propuesta de Directiva en la misma dirección y en el Congreso de los Diputamos tres Proposiciones de Ley se tramitan en estos momentos con idéntica finalidad. Si bien existe una unanimidad sin precedentes respecto al importante papel que podría ejercer el denunciante en la recta aplicación del ordenamiento jurídico y la lucha contra la corrupción, no son pocos los temas que se están abordando de forma ambigua o confusa; por ello, en este estudio nos proponemos identificarlos y realizar algunas propuestas de mejora.
APLIKASI TEMA DESAIN RUMAH SAKIT IBU DAN ANAK BERDASARKAN KARAKTER PENGGUNA RUANG
Authors: Utary Latifah , Raharadjo Setiamurti , Asharsinyo Doddy Friestya
Published: October 2019

Other than as a means of serving the special health examination of the mother during the pregnancy to pre post childbirth and providing service for the health of children, mothers and children's hospital must also pay attention to aspects of psychiatric or psychological patients and patient needs in order to design can support the recovery process. In addition to the need for facilities that can accomodate an entire user activity, its atmosphere also required space can provide a sense of comfort when residing therein. One way to build the desired room atmosphere users by application of the theme on the space. Therefore, the writing aims to determine the themes that correspond to the user's character and how these themes in the determination process. Research carried out using quantitative methods through questionnaires and continued with the qualitative method which will discuss the process of determining the desired theme and the theme of today’s society forinterior Women’s and Children’s Hospital.
La formación de los terapeutas ocupacionales. Licenciatura virtual en Terapia Ocupacional (Universidad Nacional de Quilmes): una experiencia mediatizada por la nuevas tecnologías
Authors: Demiryi María de los Milagros , Fernández María Esther
Published: October 2019

Este trabajo presenta la experiencia de la Licenciatura Virtual en Terapia Ocupacional, desarrollada por la Universidad Nacional de Quilmes desde hace más de tres años.

Comienza con una caracterización del impacto que han producido las Nuevas Tecnologías en el mundo y en las diferentes áreas. Se trata con mayor detenimiento su impacto en la educación , revisando autores e investigaciones sobre el tema.

Luego se explica la oferta académica de la Licenciatura Virtual en Terapia Ocupacional. El Plan de Estudios y la modalidad de enseñanza. Analiza los resultados de esta experiencia.

Por último, se plantean algunas reflexiones acerca del desafío educativo de la hora actual, las necesidades de formación de los terapeutas ocupacionales y el diseño de propuestas que construyan una relación dinámica entre la sociedad y currículo, a modo de articulaciones paradigmáticas.
10 años al servicio de la salud mental
Authors: Atehortua Restrepo Martha Cecilia , Tascón Rojas María del Rosario
Published: October 2019

El presente trabajo buscó sistematizar a través de una investigación cualitativa el resultado de 10 años de experiencia de la institución TERAPEUTAS OCUPACIONALES, la cual presta servicios de salud mental en la ciudad de Cali y todo el proceso que se siguió al abordar: inicialmente grupos heterogéneos en la modalidad de centro día, pasando por cambio en la intensidad horaria, para finalmente llegar a grupos homogéneos, con horarios y programas estructurados con base en diferentes modelos y marcos de referencia. Es en esta fase donde se consolidan los logros no solo para los pacientes, sino para la profesión, al ver reflejado una evolución favorable en todos los aspectos que conforman el desempeño ocupacional y como ellos experimentan el logro parcial o total de los objetivos propuestos al inicio de la intervención individual y grupal, esta ultima teniendo como base la inclusión en 1 de los 7 grupos creados de acuerdo a las características de la población a intervenir: 1. niños, 2. adolescentes, 3. personas con diagnóstico de trastornos del estado del animo y ansiedad, 4. personas con diagnóstico de trastornos psicóticos en fase aguda, 5. club de ocio, 6. personas con demencias, 7. psicoeducación a pacientes, familiares y cuidadores.
Competencias del terapeuta ocupacional en el fenómeno de las adicciones con un modelo Biopsicosocial
Authors: Rozo Reyes Claudia Marcela
Published: October 2019

Este artículo compila una experiencia de trabajo en el área de salud mental, en personas con trastornos por consumo de sustancias como alcohol, alucinógenos o anfetaminas. El marco de trabajo es un modelo biopsicosocial, a partir del cual se integra el trabajo del terapeuta ocupacional, como integrante del equipo interdisciplinar y bajo el concepto de utilizar la ocupación como propósito y como medio para restaurar los estados de salud de las personas que sufren esta enfermedad.
El papel de la cintura escapular en la postura y el movimiento
Authors: Rojas Rojas Marlen
Published: October 2019

El propósito de este artículo es revisar la importancia de las funciones motoras de la cintura escapular en el desarrollo de la postura y el movimiento sin desconocer todos los factores que intervienen y son esenciales en el aprendizaje motor del niño. Esta interpretación, mira en detalle los eventos en común de los segmentos corporales que la conforman y sus patrones de movimiento en relación con la cintura escapular, con una intención: ser usados en la intervención. La revisión de esta información y su entendimiento puede ser usada como referencia para la evaluación y tratamiento en niños con de sarrollo motor atípico y retraso motor.

Finalmente, se muestra la estructura escapular como un segmento corporal que juega un papel importante en múltiples funciones del cuerpo del niño durante su de sarrollo y por tanto, la hace de interés interdisciplinario.
Reflexiones entorno a la competencia ocupacional de la persona con trastorno esquizofrénico
Authors: Rozo Reyes Claudia Marcela
Published: October 2019

Este artículo presenta una reflexión sobre las dificultades de las personas con trastornos esquizofrénicos para lograr la competencia ocupacional. Centra su atención en las alteraciones cognoscitivas y sus repercusiones en el desempeño ocupacional, el concepto de competencia ocupacional y su directa relación con las expectativas del entorno, así como en la necesidad de privilegiar ei análisis del contexto y de la ocupación para el logro de la competencia.

Pretende contribuir en la construcción de parámetros a tener en cuenta para que el terapeuta ocupacional que desarrolle procesos de rehabilitación integral, reconozca que la intervención debe partir de factores individuales, ocupacionaies y ambientales.
Editorial
Authors: Duarte Cuervo Clara
Published: October 2019

Es un gusto presentar este nuevo número de la Revista Ocupación Humana, el primero de 2015. Consecuentes con las premisas que acordamos al asumir esta misión, hace ya dos años, seguimos trabajando para promover la generación y socialización de conocimiento. Somos conscientes de la responsabilidad que implica sacar a la luz textos que gocen de credibilidad en el gremio y que sirvan para la movilización, la actualización y la consolidación de la teoría y la práctica de la profesión.
Palabras de Aida Navas durante la celebración de los 45 años de egreso del primer grupo de terapeutas ocupacionales de la Universidad Nacional de Colombia
Authors: Navas Aida
Published: October 2019

Es un privilegio estar hoy acá celebrando el Día Nacional del Terapeuta Ocupacional y la conmemoración de los 45 años del primer grupo de terapeutas ocupacionales colombianos egresados de esta Universidad.
Significados de la ocupación en jóvenes infractores de la ley, participantes de programas de inclusión social en Chile
Authors: Palacios Tolvett Monica , Silva Dreyer Carmen
Published: October 2019

Actualmente en Chile, a la luz de la opinión pública, los jóvenes que han infringido la ley son asociados con la violencia, el consumo de drogas, y la delincuencia, haciéndose acreedores de una identidad social negativa, lo que profundiza su estigmatizadón y descalificación a priori. Así mismo, no existe una valoración de lo que ellos son, hacen, o del sentido de sus ocupaciones. Este estudio pretende responder: ¿Cuáles son los significados que los/las jóvenes infractores de ley dan a ocupaciones que realizan en su vida cotidiana?; ¿muestran estas ocupaciones atributos distintos a la infracción de la ley? Para ello se utilizó una metodología cualitativa, basada en la teoría fundada, mediante entrevistas semi-estructuradas, ocho individuales y dos grupales, efectuando codificación abierta, descripción y análisis detallado de significados. Los participantes fueron hombres y mujeres entre los 14 y los 25 años de edad, infractores de ley, pertenecientes a comunas de la Región Metropolitana, quienes hacían parte de programas de inclusión social. Los resultados muestran que los jóvenes realizan diversas ocupaciones más allá de solo la infracción de ley. Aparecen dos ejes: uno de ocupaciones aceptadas y otro de ocupaciones transgresoras, los significados positivos o negativos, para cada eje, configuran identidad y posibilidad de cambio.
Editorial
Authors: Navas Aída
Published: October 2019

El número de la Revista Ocupación Humana que hoy tiene en sus manos es, en su edición de relanzamiento, un ambicioso proyecto dirigido a recuperar la tradición editorial del Colegio Colombiano de Terapia Ocupacional. Su propósito, divulgar el conocimiento de nuestra disciplina y de la ciencia de la ocupación humana.
Estimulación cognitiva, un medio para favorecer la participación del adulto mayor
Authors: Monsalve Robayo Angélica , Peñaranda Saavedra Ángela María , Rozo Reyes Claudia Marcela
Published: October 2019

El presente artículo contiene información relacionada con el proceso normal de envejecimiento, su influencia en el desempeño cotidiano, la estimulación cognitiva como medio terapéutico, las características de las actividades que se desarrollan a través de este medio y los logros y beneficios de su aplicación para la calidad de vida del adulto mayor.

Por esta razón se profundiza principalmente en los cambios que ocurren a nivel cognitivo y cómo éstos influyen en la forma en que las personas mayores desempeñan sus actividades de la vida diaria, su posición frente al entorno familiar y social y el reconocimiento de sus posibilidades de participación .
Hacia la comprensión de la ocupación humana en Colombia y América Latina
Authors: Trujillo Rojas Alicia
Published: October 2019

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Intervención de terapia ocupacional en catástrofe. La inundación de Santa Fe
Authors: Demiryi Milagros
Published: October 2019

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Students' Attitudes and Perceptions towards the Effectiveness of Field Trips Strategy in Universitas Islam Riau, Pekanbaru
Authors: Rugaiyah Rugaiyah
Published: October 2019

This study aimed at exploring students’ attitudes and perceptions about the effectiveness of field trips strategy. The participants of this study were 40 English students of Universitas Islam Riau, Pekanbaru, Indonesia. Both qualitative and quantitative methods were applied. This study employed an exploratory mixed-method design. The questionnaire consisted of three parts and 25 items which aimed at getting information about affective learning, the qualities among students and the contribution of a field trip on Society and Individuals. A five-point Likert-scale ranging from “ strongly agree’ to “strongly disagree” was asked to respondents to be selected. While a semi-structured interviewed was used together comprehensive information about the advantages of field trips in their study. The results of this study shown that field trips contribute to students’ learning experience positively, besides it can solve many problems in the classroom and enhance the ability of students to think critically and creatively.
Diastereo- and Enantioselective CuH-Catalyzed Hydroamination of Strained Trisubstituted Alkenes
Authors: Feng Sheng , Hao Hua , Liu Peng , Buchwald Stephen L.
Published: October 2019

Amine-substituted cyclobutanes and cyclopropanes are important substructures in biologically active compounds. Moreover, many of the cycloalkane units bear multiple substituents and stereocenters. Therefore, synthetic methods that produce polysubstituted aminocyclobutanes and aminocyclopropanes in a highly diastereo- and enantioselective manner are of importance. Herein, we describe the diastereo- and enantioselective synthesis of various types of polysubstituted aminocyclobutanes and aminocyclopropanes through CuH-catalyzed hydroamination of 1-substituted cyclobutenes and cyclopropenes. These strained trisubstituted alkenes exhibit much higher reactivity compared to their unstrained analogues in the initial hydrocupration step of the reaction. Moreover, an interesting reversal of regioselectivity was observed in the hydroamination of 1-aryl-substituted cyclobutenes compared to the cyclopropene analogues. The origins of the enhanced reactivity of strained trisubstituted alkenes as well as the differences in the regio- and enantioselectivity between reactions with cyclobutenes and cyclopropenes were investigated computationally.
Site-Specific Generation of Protein-Protein Conjugates Using Native Amino Acids
Authors: Lobba Marco , Fellmann Christof , Marmelstein Alan , Maza Johnathan , Kissman Elijah , Robinson Stephanie A. , Staahl Brett T. , Urnes Cole , Lew Rachel J. , Doudna Jennifer A. , Francis Matthew
Published: October 2019

Chimeric protein-protein conjugates provide platforms for immunotherapy, targeted drug delivery, and vaccine development. However, many desirable constructs cannot be produced through direct expression, and the targeted coupling of two proteins is chemically challenging. Here we present a new approach for the rapid and site-specific coupling of proteins using native amino acids. Tyrosinase oxidizes exposed tyrosine residues on polypeptides, generating ortho-quinones that react rapidly with strategically placed cysteine residues in other proteins. This approach was used to modify CRISPR-Cas9 and other substrates with small molecules, peptides and even intact proteins. The conjugation of cell penetrating peptides to CRISPR-Cas9 was shown to increase cellular genome editing efficiency by 20-fold relative to unmodified Cas9. This technology represents a new paradigm for biomolecular coupling, and paves the way to an unprecedented range of multifunctional bioconjugates.
The ramification of fermentation time on antioxidant properties of Napier grass herbal tea by black tea processing method
Authors: Ng K.S. , Mohd Zin Zamzahaila , Mohd Maidin Nurmahani , Zainol M.K.
Published: October 2019

Tea fermentation relates to the enzymatic oxidation of the leaves of the tea and the
formation of dark pigments. This method is usually conducted in a setting where
temperature and humidity can be regulated. However, the impact of fermentation time on
the antioxidant characteristics of Napier grass herbal tea is still unanswered. This study
aimed to determine the effect of fermentation time on antioxidant properties of Napier
grass black tea. Napier grass was subjected to fermentation for 3, 6, 9, 12 and 24 hrs.
Fresh and dried samples were extracted in water (95°C, 30 mins) and the extracts were
then analysed by total phenolic content (TPC) assay, total flavonoid content (TFC) assay,
diphenyl-picryl-hydrazyl (DPPH) assay, Ferric reducing antioxidant potential (FRAP)
assay, ferric thiocyanate (FTC) method and thiobarbituric acid (TBA) method. Sample
fermented for 9 hrs showed the highest results in TPC (18.32±0.38) and FRAP assay
(91.00±2.78). Whereas, the highest flavonoids and antioxidant activity were found in
dried sample without fermentation (control) in TFC (97.82±13.00) and DPPH
(90.02±1.11). However, samples fermented for 3 to 9 hrs showed no significant difference
with that of the fresh sample in TFC and DPPH indicating 3 to 9 hrs fermentation time did
not affect the antioxidant properties of Napier grass. In FTC and TBA, all the fermented
samples showed lower antioxidant activity than that of fresh samples and control. The
results suggested that 9 h of fermentation time is suitable for the preparation of Napier
grass black tea as it exhibited high antioxidant properties in TPC, TFC, DPPH and FRAP
assays.
Представление о водородной связи, следующее из теории обобщенных зарядов
Authors: Долгоносов А.М.
Published: October 2019

Теория обобщенных зарядов, представляющая собой асимптотическое приближение для межатомных сил квантово-статистической модели многокомпонентного электронного газа, позволяет вывести новые закономерности для энергии и длины межатомных связей в виде функций от атомного номера, кратности связи и орбитального момента. В частности, получены выражения для энергии и длины связи у гидридов через атомный номер. Следствие развиваемой теории — представление о водородной связи как об одноэлектронной ковалентной — соответствующие количественные соотношения. Показано, что энергия водородной связи не может быть слабее некоторой величины, определяемой зарядом ядра связываемого атома. Установлена область существования водородной связи, границы которой разделяют классы веществ по способности к водородному связыванию. На основе количественных оценок объясняется наличие или отсутствие растворимости в воде веществ, содержащих электроотрицательные атомы.
Структура двух комплексов N-тиофосфорилированных тиоамидов с катионом серебра(I) и трифенилфосфином
Authors: Литвинов И.А. , Карамов Ф.А.
Published: October 2019

С целью изучения комплексообразующих свойств N-тиофосфорилированных тиомочевин, тиоамидов и тиосемикарбазидов с общей формулой RC(S)NHP(S)(OPri)2 (R = AlkNH, Alk2N, ArNH, PyNH, Ph, PhNHNH, NH2(Et)N) по отношению к катионам меди(I) и серебра(I) установлена молекулярная и кристаллическая структура (трифенилфосфин-Р)[N-(диизопропокситиофосфорил)тиобензамидо-S,S']серебра(I) и бис-(три­фенилфосфин-Р)[N-(диизопропокситиофосфорил)тиобензамид-S,S'] серебра(I).
Theoretical evaluation of the one-pot synthesis of aliphatic PNP pincer ligands
Authors: Mohammadnezhad G. , Abad S. , Farrokhpour H.
Published: October 2019

In this research, the one-pot synthesis of aliphatic pincer ligands via the SN2 reaction is studied using theoretical calculations. The kinetics and thermodynamics of the reactions between dialkylhalophosphines and bis(2-haloethyl)amines are studied and compared with the experimentally successful one-pot synthesis of arene-based PCP/PNP pincer ligands. The effect of the leaving group, heteroatom, solvent, and substitution are investigated, and it has been shown that the synthesis of aliphatic pincer ligands with iodophosphines and bis(2-iodoethyl)amine in the presence of acetonitrile as a solvent have the lowest activation free energy (ΔG≠) and the highest reaction rate (k). Consequently, the calculations suggest the suitable condition for the one-pot synthesis of aliphatic pincer ligands via the proposed SN2 reaction.
Multiannual occurrence of mycotoxins in feed ingredients and complete feeds for pigs in the Czech Republic
Authors: Svoboda Martin , Blahová Jana , Honzlová Alena , Kalinová Jana , Macharáčková Pavla , Rosmus Jan , Mejzlík Vít , Kúkol Patrik , Vlasáková Veronika , Mikulková Karolína
Published: October 2019

The aim of the study was to evaluate the individual and combined occurrence of mycotoxins in feed ingredients and complete feeds for pigs in the Czech Republic in the years 2013–2017. The samples were analysed for the occurrence of aflatoxins (AF), deoxynivalenol (DON), zearalenone (ZEA), ochratoxin A (OTA), fumonisins (FUM), and T-2/H-2 toxins. The mycotoxin most commonly found in maize and small cereal grain samples was deoxynivalenol (94% and 53%, respectively). Deoxynivalenol was also the most frequent mycotoxin in all types of swine feed. The most frequent mycotoxin combinations in the total number of samples were DON + ZEA (56.63%), DON + OTA (11.61%) and DON + sum of T2/HT2 (9.76%). The maximum values set by the European Commission for mycotoxin levels in feed ingredients and complete feeds were exceeded in the case of AFB1, deoxynivalenol, zearalenone, ochratoxin A and T-2/H-2 toxins. Our findings support the need for further monitoring of mycotoxins in feed ingredients and complete feeds for pigs in the Czech Republic.
HYPOTHETICAL VORTEX-MOTIVE FORCE OR A REALIZATION OF THE TURBULENT VORTEX DYNAMO IN THE TROPICAL ATMOSPHERE
Authors: Levina G.V.
Published: October 2019

The review (Levina et al., 2000) contains a detailed discussion of a series of studies of 1983–1999 related to the creation (1983) and the further development of the mathematical model of a turbulent vortex dynamo. The model was obtained by the methods of the mean-field theory (Krauze and Redler, 1984) and for the first time contained a largescale instability in an electrically non-conducting medium (hydrodynamic alpha effect) generated by the special properties of small-scale helical turbulence of the velocity field. By analogy with the model of the alpha effect in magnetohydrodynamics, such instability is described by a generating term obtained by averaging the equations for the turbulent velocity field and representing a force of some kind in the physical sense. However, unlike the magnetohydrodynamics, where the mean electromotive force acts as the generating term, the interpretation of the result obtained in the model of the hydrodynamic alpha effect caused serious difficulties for a long time. Indeed, the emergence of the mean electromotive force can be explained by the interaction of the magnetic field and the velocity field. In the case of a non-conducting medium, the obtained hypothetical force, for definiteness, let us call it, for example, a “vortex-motive” force, should be created by the velocity field alone. In nature, such force is unknown, but on the basis of new knowledge about atmospheric convection in the tropics, we have been able to interpret the vortex-motive force as a parameterization (Levina, 2018) of the interaction of several effects - rotating deep moist convection (Hendricks et al., 2004), accompanied by intense volumetric heat release, and vertical shear horizontal wind.
The proposed parameterization allows us to explain the implementation of turbulent vortex dynamo in the tropical atmosphere.
This work was supported by the Russian Foundation for Basic Research (RFBR) under Grant 16-05-00551a
AN EMPIRICAL STUDY OF THE CRITICAL TRANSITION IN THE PLEISTOCENE CLIMATE BASED ON NONLINEAR DYNAMIC RECONSTRUCTION
Authors: Loskutov E.M. , Mukhin D.N. , Gavrilov A.S. , Kurths J. , Feigin A.M.
Published: October 2019

Until now, cause of the Mid-Pleistocene Transition (MPT), when the dominant periodicity of climate cycles changed from 41,000 to 100,000 years in the absence of significant change in orbital forcing, are still an open question in Paleoclimatology. Here we show how a Bayesian data analysis and nonlinear dynamical reconstruction methods can help to reveal the main mechanisms underlying the Pleistocene variability. Our Bayesian data-driven model from benthic d18O records (LR04 stack) accounts the main factors which may potentially impact climate of the Pleistocene: internal climate dynamics, gradual trends, variations of insolation, and millennial variability. In contrast to some theories, we uncover that under long-term trends in climate, the strong glacial cycles have appeared due to internal nonlinear oscillations induced by millennial noise. We find that while the orbital Milankovitch forcing does not matter for the MPT onset, the obliquity oscillation phase-locks the climate cycles through the meridional gradient of insolation.
The research was supported by the RAS Presidium Program «Nonlinear dynamics: fundamental problems and applications».
A MODEL OF THE VERTICAL MIXING INDUCED BY WIND WAVES
Authors: Polnikov V.G.
Published: October 2019

The task of the work is to obtain formulas for the vertical mixing coefficient in-duced by wind waves.
ОBSERVATION OF FERMI-PASTA-ULAM-TSINGOU RECURRENCE IN OPTICAL EXPERIMENT
Authors: Pierangeli D. , Flammini M. , Marcucci G. , Agranat A.J. , Grinevich P.G. , Santini P.M. , Conti C. , DelRe E.
Published: October 2019

Recently P.G. Grinevich and P.M. Santini suggested simple approximate formulas for solving periodic Cauchy problem for the focusing Nonlnear Schrodinger Equation (NLS) under assumption that one starts from a small perturbation of the unstable condensate and the number of unstable modes is not too large. With the help of these results, optical experiments in photorefractive crystal where conducted, in which the second and third return of anomalous waves was observed. A good agreement between the experimental data and the predictions made on the basis of the NLS theory was obtained.
P.G. Grinevich was supported by the Russian Science Foundation grant No. 18-11-00316.
Evaluación del conocimiento del método de conteo de carbohidratos y estado nutricio en adolescentes con diabetes mellitus tipo 1 que acuden al “Campo Amigo” de la Asociación Mexicana de Diabetes, Nuevo León A.C. 2016-2017.
Authors: Brito Alvarez LN. Marisol , Hernández Arizpe MSP Leticia Maria , Martínez González Dr. Gustavo Israel
Published: October 2019

Introducción: El conteo de carbohidratos es una herramienta que consiste en cuantificar los hidratos de carbono de los alimentos para estimar unidades de insulina a aplicar y mejorar niveles glicémicos.Objetivo: Evaluar y comparar el conocimiento del método de conteo de carbohidratos en el “Campo Amigo” 2017, generado durante el Campo Amigo 2016 de la Asociación Mexicana de Diabetes en Nuevo León A.C., en adolescentes con Diabetes Mellitus Tipo 1.Materiales y métodos: estudio mixto, longitudinal, correlacional y descriptivo, con 24 adolescentes entre 13-18 años con DM1. Se evaluó aplicación del método de CC mediante encuesta; analizando peso, talla, IMC, HbA1c y glucosa. Se realizaron tablas de frecuencia con dos variables (Comparativo Anual) confrontada con resto de variables, con 95% de confiabilidad.Resultados y Discusión: el conocimiento del método de CC fue igual en 2016 vs 2017 con media de 71.04%, la media de conocimiento del CC fue mayor en niveles adecuados de glucosa (76.26%), estado nutricio normal (83%) y la HbA1c fuera del rango (85%). Los adolescentes aplicaron la técnica de CC pero reportaron desconocerla.Conclusión: el método de CC es una herramienta útil, pero requiere continua educación; a mayor conocimiento del método de CC adecuados parámetros de control.
Information ethics: why and how we teach the subject (Turkey)
Authors: Durukan Ayşe Yüksel
Published: October 2019

School librarians have always strived to teach information ethics to students. The importance of conveying the concept of information ethics to students has become critical within the overwhelming effect of data and information flow. In an age of massive information flow we need to address the issues related to that subject: ethics vs. wrongdoing, propoganda vs. accuracy, bias vs. neutrality, prejudice vs. objectivity, self opinionatedness vs. flexibility, fiction vs. documentary, fact vs. opinion.

Turkish communities largely depend on oral culture. The codes of a written culture maybe unknown to some part of the population. In Turkey generally school librarians are not expected to teach. Most schools may not even have a certified librarian. Those who happen to work at schools are not expected to have a teaching certificate. Teachers at schools who speciliaze on subjects may teach about ethics, in case the issue is in question. Primary years programme has scheduled the subject Thinking in education which involves a chapter on citizenship and democracy education; the subject is offered as a elective. High school grades 10 and 11 will study philosphy but Being, Ethics, Art and Religion topics are undervalued. We as school librarians can fill in the gaps. We need to be role models in teaching media literacy, academic honesty and integrity, and above all the culture of information. Collaboration with teachers is a necessity, teaching information ethics related to the student lives, with direct examples drawn from their life- experiences are very important. If we teach the subject in a dull way, with irrelevant examples it makes no sense to them and they can easily disconnect. We need to adddress the issue of using text online, voice call, images and videos, the differences and similarities. We need to be information curators for our communities.
Information Needs and Library Services Delivery for Students with Visual Impairment in Oyo State, Nigeria
Authors: Aramide Kolawole Akinjide , Lawal Wasiu Olayide , Odunlade Rachael Opeyemi
Published: October 2019

This study investigated the information needs and library service delivery to students with visual impairment in Oyo State, Nigeria with a focus on assessing the influence of library 1 services; information needs; media formats availability and accessibility on library use among students with visual impairment in Oyo State, Nigeria. The study established educational information, health information and information on coping with their visual impairment as major information needs of the visually impaired students while circulation service, reference service and screen reading service on computers are found to be the only library services provided for them. Print Books/Magazines, Braille Books and Braille-in-Print were found to be prominent among the few media-formats available for the students while the dearth of media-formats was found to be inadequate in meeting the information needs of students with visual impairment in Oyo State. Lack of ease of accessing the library resources, facilities as well as library staff whenever they need help, poor policy on borrowing privileges, lack of path sounders to guide their movement around the library among others were major accessibility issues confronting the students in enjoying quality library services. The study recommended the need to address the provision of basic facilities that are critical to effective library service delivery to the visually impaired students.
Repositioning School Libraries towards Attainment of Learning without Borders
Authors: Anyanwu Emmanuel U. , Oduagwu Emmanuel A. , Benson Oyemike Victor , Obichere Charles
Published: October 2019

The internet has revolutionized the global world system. Every aspect of the globe is under the influence of information and communication technologies. The educational sector is experiencing a paradigm shift towards a borderless economy and school libraries occupy a central place in the actualization of sustainable education. The paper highlights the need to reposition school librarianship to ensure actualization of learning without borders, the significance of school libraries in learning without borders agenda. Repositioning of school libraries requires addressing personnel issues, ICT-related issues, funding, extensive lobbying and advocacy, partnership with NGOs and stakeholders in educational sector, recruitment of qualified library staff and re-training of existing school library staff to meet global realities.