bluuebunny/crossref_metadata_2025 huggingface dataset:
Efficacy of a technology-based client-centred training system in neurological rehabilitation: a randomised controlled trial
Authors: Knippenberg Els , Timmermans Annick , Coolen Jolijn , Neven Katrien , Hallet Peter , Lemmens Jolien , Spooren Annemie
Published: December 2021

Background

A client-centred task-oriented approach has advantages towards motivation and adherence to therapy in neurorehabilitation, but it is costly to integrate in practice. An intelligent Activity-based Client-centred Training (i-ACT), a low-cost Kinect-based system, was developed which integrates a client-centred and task-oriented approach. The objectives were (1) to investigate the effect of additional i-ACT training on functioning. And (2) to assess whether training with i-ACT resulted in more goal oriented training.

Methods

A single-blind randomised controlled trial was performed in 4 Belgian rehabilitation centres with persons with central nervous system deficits. Participants were randomly allocated through an independent website-based code generator using blocked randomisation (n = 4) to an intervention or control group. The intervention group received conventional care and additional training with i-ACT for 3 × 45 min/week during 6 weeks. The control group received solely conventional care. Functional ability and performance, quality of life (QoL), fatigue, trunk movement, and shoulder active range of motion (AROM) were assessed at baseline, after 3 weeks and 6 weeks of training, and 6 weeks after cessation of training. Data were analysed using non-parametric within and between group analysis.

Results

47 persons were randomised and 45 analysed. Both intervention (n = 25) and control (n = 22) group improved over time on functional ability and performance as measured by the Wolf Motor Function Test, Manual Ability Measure-36, and Canadian Occupational Performance Measure, but no major differences were found between the groups on these primary outcome measures. Regarding QoL, fatigue, trunk movement, and shoulder AROM, no significant between group differences were found. High adherence for i-ACT training was found (i.e. 97.92%) and no adverse events, linked to i-ACT, were reported. In the intervention group the amount of trained personal goals (88%) was much higher than in the control group (46%).

Conclusions

Although additional use of i-ACT did not have a statistically significant added value regarding functional outcome over conventional therapy, additional i-ACT training provides more individualised client-centred therapy, and adherence towards i-ACT training is high. A higher intensity of i-ACT training may increase therapy effects, and should be investigated in future research.

Trial registration: ClinicalTrials.gov Identifier NCT02982811. Registered 29 November 2016.
Survival prognostic and recurrence risk factors after single pulmonary metastasectomy
Authors: Forster Céline , Ojanguren Amaya , Perentes Jean Yannis , Zellweger Matthieu , Krueger Thorsten , Abdelnour-Berchtold Etienne , Gonzalez Michel
Published: December 2021

Background

Identification of the prognostic factors of recurrence and survival after single pulmonary metastasectomy (PM).

Methods

Retrospective analysis of all consecutive patients who underwent PM for a single lung metastasis between 2003 and 2018.

Results

A total of 162 patients with a median age of 64 years underwent single PM. Video-Assisted Thoracic Surgery (VATS) was performed in 83.9% of cases. Surgical resection was achieved by wedge in 73.5%, segmentectomy in 7.4%, lobectomy in 17.9% and pneumonectomy in 1.2% of cases. The median durations of hospital stay and of drainage were 4 days (IQR 3–7) and 1 day (IQR 1–2), respectively. During the follow-up (median 31 months; IQR 15–58), 93 patients (57.4%) presented recurrences and repeated PM could be realized in 35 patients (21.6%) achieved by VATS in 77.1%. Non-colorectal tumour (HR 1.84), age < 70 years (HR 1.77) and previous extra-thoracic metastases (HR 1.61) were identified as prognostic factors of recurrence. Overall survival at 5-year was estimated at 67%. Non-colorectal tumour (HR 2.40) and mediastinal lymph nodes involvement (HR 3.42) were significantly associated with an increased risk of death.

Conclusions

Despite high recurrence rates after PM, surgical resection shows low morbidity rate and acceptable long-term survival, thus should remain the standard treatment for single pulmonary metastases.

Trial registration: The Local Ethics Committee approved the study (No. 2019–02,474) and individual consent was waived.
Surgical techniques for aortic valve xenotransplantation
Authors: Kwon Jennie H. , Hill Morgan , Gerry Brielle , Kubalak Steven W. , Mohiuddin Muhammad , Kavarana Minoo N. , Rajab T. Konrad
Published: December 2021

Background

Heart valve replacement in neonates and infants is one of the remaining unsolved problems in cardiac surgery because conventional valve prostheses do not grow with the children. Similarly, heart valve replacement in children and young adults with contraindications to anticoagulation remains an unsolved problem because mechanical valves are thrombogenic and bioprosthetic valves are prone to early degeneration. Therefore, there is an urgent clinical need for growing heart valve replacements that are durable without the need for anticoagulation.

Methods

A human cadaver model was used to develop surgical techniques for aortic valve xenotransplantation.

Results

Aortic valve xenotransplantation is technically feasible. Subcoronary implantation of the valve avoids the need for a root replacement.

Conclusion

Aortic valve xenotransplantation is promising because the development of GTKO.hCD46.hTBM transgenic pigs has brought xenotransplantation within clinical reach.
A heart in a heart: a case report of spontaneous flail of bicuspid aortic valve
Authors: Mohammadi Khadije , Akrami Mahsa , Mirtajaddini Marzieh
Published: December 2021

Background

Aortic regurgitation is attributed to congenital and acquired abnormalities of the aortic valve or aortic valve supporting structures. The most common cause of aortic regurgitation is atherosclerotic degeneration of the valve, especially in the presence of a bicuspid aortic valve.

Case summary

A 25-year-old Persian man with no past medical history, developed dyspnea since 1 week before his first visit to the physician. He was an active person up to this time, and had no history of trauma or chest pain. Transthoracic echocardiography showed severe aortic regurgitation in the context of flail bicuspid aortic valve, with no evidence of endocarditis. Laboratory tests including blood cultures were negative for infection. The patient underwent aortic valve replacement and the diagnosis was confirmed at time of surgery.

Conclusion

This case represents noninfective and nontraumatic spontaneous flail of bicuspid aortic valve.
Bayesian inference of biomass growth characteristics for sugi (C. japonica) and hinoki (C. obtusa) forests in self-thinned and managed stands
Authors: Nicoulaud-Gouin Valérie , Gonze Marc-André , Hurtevent Pierre , Calmon Phillippe
Published: December 2021

Background

Forests are an important sink for atmospheric carbon and could release that carbon upon deforestation and degradation. Knowing stand biomass dynamic of evergreen forests has become necessary to improve current biomass production models. The different growth processes of managed forests compared to self-managed forests imply an adaptation of biomass prediction models.

Methods

In this paper we model through three models the biomass growth of two tree species (Japanese cedar, Japanese cypress) at stand level whether they are managed or not (self-thinning). One of them is named self-thinned model which uses a specific self-thinning parameter α and adapted to self-managed forests and an other model is named thinned model adapted to managed forests. The latter is compared to a Mitscherlich model. The self-thinned model takes into account the light competition between trees relying on easily observable parameters (e.g. stand density). A Bayesian inference was carried out to determine parameters values according to a large database collected.

Results

In managed forest, Bayesian inference results showed obviously a lack of identifiability of Mitscherlich model parameters and a strong evidence for the thinned model in comparison to Mitscherlich model. In self-thinning forest, the results of Bayesian inference are in accordance with the self-thinning 3/2 rule (α=1.4). Structural dependence between stand density and stand yield in self-thinned model allows to qualifying the expression of biological time as a function of physical time and better qualify growth and mortality rate. Relative mortality rate is 2.5 times more important than relative growth rate after about 40 years old. Stand density and stand yield can be expressed as function of biological time, showing that yield is independent of initial density.

Conclusions

This paper addressed stand biomass dynamic models of evergreen forests in order to improve biomass growth dynamic assessment at regional scale relying on easily observable parameters. These models can be used to dynamically estimate forest biomass and more generally estimate the carbon balance and could contribute to a better understanding of climate change factors.
Tuberculosis infection among youths in overcrowded university hostels in Kenya: a cross-sectional study
Authors: Maina Teresia , Willetts Annie , Ngari Moses , Osman Abdullahi
Published: December 2021

Background

Tuberculosis (TB) remains a top global health problem and its transmission rate among contacts is higher when they are cohabiting with a person who is sputum smear-positive. Our study aimed to describe the prevalence of TB among student contacts in the university and determine factors associated with TB transmission.

Methods

We performed a cross-sectional study with an active contact case finding approach among students receiving treatment at Kilifi County Hospital from January 2016 to December 2017. The study was conducted in a public university in Kilifi County, a rural area within the resource-limited context of Kenya. The study population included students attending the university and identified as sharing accommodation or off-campus hostels, or a close social contact to an index case. The index case was defined as a fellow university student diagnosed with TB at the Kilifi County Hospital during the study period. Contacts were traced and tested for TB using GeneXpert.

Results

Among the 57 eligible index students identified, 51 (89%) agreed to participate. A total of 156 student contacts were recruited, screened and provided a sputum sample. The prevalence of TB (GeneXpert test positive/clinical diagnosis) among all contacts was 8.3% (95% CI 4.5–14%). Among the 8.3% testing positive 3.2% (95% CI 1.0–7.3%) were positive for GeneXpert only. Sharing a bed with an index case was the only factor significantly associated with TB infection. No other demographic or clinical factor was associated with TB infection.

Conclusion

Our study identified a high level of TB transmission among university students who had contact with the index cases. The study justifies further research to explore the genetic sequence and magnitude of TB transmission among students in overcrowded university in resource limited contexts.
The identity changes in online learning and teaching: instructors, learners, and learning management systems
Authors: Kwon Soyeong , Kim Woolchul , Bae Changyeon , Cho Minjang , Lee Seunghoon , Dreamson Neal
Published: December 2021

Not because of the unexpected global pandemic, but because of the emergence of educational technology and pedagogical innovation, the ways of teaching and learning have been switched to technology integrated modes such as blended and flipped learning which is more than changing to online from face-to-face. Yet, many institutes, which rely on a conventional residential teaching mode or use learning management systems (LMS) as an additive tool, are further struggling to adjust to the new environment. In this paper, we argue that the identity changes of three components, instructor, learner, and LMS are inevitable for authentic online teaching and learning. By applying conceptual frameworks for the identity changes with four sequential levels, we evaluated Blackboard course sites (n = 53) and analysed course evaluations (n = 41) from a university that remained holding a traditional classroom mode and using an LMS in a non-integrated way. As a result, only a few courses appeared at higher levels of the identity changes. To integrate the identity changes in online learning and teaching, we argue that an LMS should be designed and managed as a learning community; both instructors and learners should be repositioned as co-participants; and they should work together to build a post-learning community by practicing community membership.
Effect of functional electrical stimulation versus TheraTogs on gait and balance in children with hemiplegic cerebral palsy: a randomized controlled trial
Authors: El-Shamy Shamekh Mohamed , El Kafy Ehab Mohamed Abd
Published: December 2021

Background

Children with cerebral palsy exhibit postural restrictions and gait problems as a result of both primary and secondary brain damage impairments. One of the main goals of cerebral palsy rehabilitation is to improve gait and balance. As a result, the purpose of this study was to compare the effects of FES and TheraTogs on gait and balance in children with hemiplegic CP. A randomized controlled study was conducted on 30 children with hemiplegic CP (18 boys and 12 girls) between the ages of 8 and 12 years. The children were divided into two equal groups. In addition to the traditional physical treatment program, the FES group received functional electrical stimulation (pulse width 300 μs, frequency 33 Hz, 2 h/day, 3 days/week, 3 months). The TheraTogs group, on the other hand, received the TheraTogs strapping system as well as the same traditional program for the same time period. The 3-D motion analysis and the Biodex balance system were used to analyze gait parameters and postural stability at baseline and 3 months after the intervention.

Results

When comparing the mean values of the gait parameters and postural stability indices of children in both groups before and after treatment, a significant improvement was reported. Furthermore, the FES group showed a greater improvement in all of the measured outcomes (P < 0.001).

Conclusion

Functional electrical stimulation improves gait pattern and postural stability in children with hemiplegic cerebral palsy significantly more than TheraTogs strapping systems.

Clinical trial registration

This study was registered in the ClinicalTrial.gov PRS (NCT05020834).
The Saline Infusion Test for Primary Aldosteronism: Implications of Immunoassay Inaccuracy
Authors: Eisenhofer Graeme , Kurlbaum Max , Peitzsch Mirko , Constantinescu Georgiana , Remde Hanna , Schulze Manuel , Kaden Denise , Müller Lisa Marie , Fuss Carmina T , Kunz Sonja , Kołodziejczyk-Kruk Sylwia , Gruber Sven , Prejbisz Aleksander , Beuschlein Felix , Williams Tracy Ann , Reincke Martin , Lenders Jacques W M , Bidlingmaier Martin
Published: December 2021

Context

Diagnosis of primary aldosteronism (PA) for many patients depends on positive results for the saline infusion test (SIT). Plasma aldosterone is often measured by immunoassays, which can return inaccurate results.

Objective

This study aimed to establish whether differences in aldosterone measurements by immunoassay versus mass spectrometry (MS) might impact confirmatory testing for PA.

Methods

This study, involving 240 patients tested using the SIT at 5 tertiary care centers, assessed discordance between immunoassay and MS-based measurements of plasma aldosterone.

Results

Plasma aldosterone measured by Liaison and iSYS immunoassays were respectively 86% and 58% higher than determined by MS. With an immunoassay-based SIT cutoff for aldosterone of 170 pmol/L, 78 and 162 patients had, respectivel, negative and positive results. All former patients had MS-based measurements of aldosterone < 117 pmol/L, below MS-based cutoffs of 162 pmol/L. Among the 162 patients with pathogenic SIT results, MS returned nonpathologic results in 62, including 32 under 117 pmol/L. Repeat measurements by an independent MS method confirmed nonpathogenic results in 53 patients with discordant results. Patients with discordant results showed a higher (P < 0.0001) prevalence of nonlateralized than lateralized adrenal aldosterone production than patients with concordant results (83% vs 28%). Among patients with nonlateralized aldosterone production, 66% had discordant results. Discordance was more prevalent for the Liaison than iSYS immunoassay (32% vs 16%; P = 0.0065) and was eliminated by plasma purification to remove interferents.

Conclusion

These findings raise concerns about the validity of immunoassay-based diagnosis of PA in over 60% of patients with presumed bilateral disease. We provide a simple solution to minimize immunoassay inaccuracy-associated misdiagnosis of PA.
Co-existing Neuropeptide FF and Gonadotropin-Releasing Hormone 3 Coordinately Modulate Male Sexual Behavior
Authors: Umatani Chie , Yoshida Nagisa , Yamamoto Eri , Akazome Yasuhisa , Mori Yasutaka , Kanda Shinji , Okubo Kataaki , Oka Yoshitaka
Published: December 2021

Animals properly perform sexual behaviors by using multiple sensory cues. However, neural mechanisms integrating multiple sensory cues and regulating motivation for sexual behaviors remain unclear. Here, we focused on peptidergic neurons, terminal nerve gonadotropin-releasing hormone (TN-GnRH) neurons, which receive inputs from various sensory systems and co-express neuropeptide FF (NPFF) in addition to GnRH. Our behavioral analyses using knockout medaka of GnRH (gnrh3) and/or NPFF (npff) demonstrated that some sexual behavioral repertoires were delayed, not disrupted, in gnrh3 and npff single knockout males, while the double knockout appeared to alleviate the significant defects that were observed in single knockouts. We also found anatomical evidence to show that both neuropeptides modulate the sexual behavior-controlling brain areas. Furthermore, we demonstrated that NPFF activates neurons in the preoptic area via indirect pathway, which is considered to induce the increase in motivation for male sexual behaviors. Considering these results, we propose a novel mechanism by which co-existing peptides of the TN-GnRH neurons, NPFF, and GnRH3 coordinately modulate certain neuronal circuit for the control of behavioral motivation. Our results may go a long way toward understanding the functional significance of peptidergic neuromodulation in response to sensory information from the external environments.
Hypothalamic-Pituitary and Other Endocrine Surveillance Among Childhood Cancer Survivors
Authors: van Iersel Laura , Mulder Renee L , Denzer Christian , Cohen Laurie E , Spoudeas Helen A , Meacham Lillian R , Sugden Elaine , Schouten-van Meeteren Antoinette Y N , Hoving Eelco W , Packer Roger J , Armstrong Gregory T , Mostoufi-Moab Sogol , Stades Aline M , van Vuurden Dannis , Janssens Geert O , Thomas-Teinturier Cécile , Murray Robert D , Di Iorgi Natascia , Neggers Sebastian J C M M , Thompson Joel , Toogood Andrew A , Gleeson Helena , Follin Cecilia , Bardi Edit , Torno Lilibeth , Patterson Briana , Morsellino Vera , Sommer Grit , Clement Sarah C , Srivastava Deokumar , Kiserud Cecilie E , Fernandez Alberto , Scheinemann Katrin , Raman Sripriya , Yuen Kevin C J , Wallace W Hamish , Constine Louis S , Skinner Roderick , Hudson Melissa M , Kremer Leontien C M , Chemaitilly Wassim , van Santen Hanneke M
Published: December 2021

Endocrine disorders in survivors of childhood, adolescent, and young adult (CAYA) cancers are associated with substantial adverse physical and psychosocial effects. To improve appropriate and timely endocrine screening and referral to a specialist, the International Late Effects of Childhood Cancer Guideline Harmonization Group (IGHG) aims to develop evidence and expert consensus-based guidelines for healthcare providers that harmonize recommendations for surveillance of endocrine disorders in CAYA cancer survivors. Existing IGHG surveillance recommendations for premature ovarian insufficiency, gonadotoxicity in males, fertility preservation, and thyroid cancer are summarized. For hypothalamic-pituitary (HP) dysfunction, new surveillance recommendations were formulated by a guideline panel consisting of 42 interdisciplinary international experts. A systematic literature search was performed in MEDLINE (through PubMed) for clinically relevant questions concerning HP dysfunction. Literature was screened for eligibility. Recommendations were formulated by drawing conclusions from quality assessment of all evidence, considering the potential benefits of early detection and appropriate management. Healthcare providers should be aware that CAYA cancer survivors have an increased risk for endocrine disorders, including HP dysfunction. Regular surveillance with clinical history, anthropomorphic measures, physical examination, and laboratory measurements is recommended in at-risk survivors. When endocrine disorders are suspected, healthcare providers should proceed with timely referrals to specialized services. These international evidence-based recommendations for surveillance of endocrine disorders in CAYA cancer survivors inform healthcare providers and highlight the need for long-term endocrine follow-up care in subgroups of survivors and elucidate opportunities for further research.
First Japanese Family With PDX1-MODY (MODY4): A Novel PDX1 Frameshift Mutation, Clinical Characteristics, and Implications
Authors: Yoshiji Satoshi , Horikawa Yukio , Kubota Sodai , Enya Mayumi , Iwasaki Yorihiro , Keidai Yamato , Aizawa-Abe Megumi , Iwasaki Kanako , Honjo Sachiko , Hosomichi Kazuyoshi , Yabe Daisuke , Hamasaki Akihiro
Published: December 2021

Context

The PDX1 gene encodes pancreatic and duodenal homeobox, a critical transcription factor for pancreatic β-cell differentiation and maintenance of mature β-cells. Heterozygous loss-of-function mutations cause PDX1-MODY (MODY4).

Case Description

Our patient is an 18-year-old lean man who developed diabetes at 16 years of age. Given his early-onset age and leanness, we performed genetic testing. Targeted next-generation sequencing and subsequent Sanger sequencing detected a novel heterozygous frameshift mutation (NM_00209.4:c.218delT. NP_000200.1: p.Leu73Profs*50) in the PDX1 transactivation domain that resulted in loss-of-function and was validated by an in vitro functional study. The proband and his 56-year-old father, who had the same mutation, both showed markedly reduced insulin and gastric inhibitory polypeptide (GIP) secretion compared with the dizygotic twin sister, who was negative for the mutation and had normal glucose tolerance. The proband responded well to sitagliptin, suggesting its utility as a treatment option. Notably, the proband and his father showed intriguing phenotypic differences: the proband had been lean for his entire life but developed early-onset diabetes requiring an antihyperglycemic agent. In contrast, his father was overweight, developed diabetes much later in life, and did not require medication, suggesting the oligogenic nature of PDX1-MODY. A review of all reported cases of PDX1-MODY also showed heterogeneous phenotypes regarding onset age, obesity, and treatment, even in the presence of the same mutation.

Conclusions

We identified the first Japanese family with PDX1-MODY. The similarities and differences found among the cases highlight the wide phenotypic spectrum of PDX1-MODY.
Heteroatom Exchange Chemistry in (Z)-1-R-2-(4′,4′-dimethyl)-2′-oxazolin-2′yl)-eth-1-en-1-ols: Access to Chelate-stabilized Thioester Analogues of Dithiooxophosphoranes
Authors: Hill Matthew C , Lough Alan J , Gossage Robert A
Published: December 2021

The exploration of S- or Se-for-O exchange with (Z)-1-R-2-(4′,4′-dimethyl-2′-oxazolin-2′-yl)-eth-1-en-1-ols (1: R = Ph, Me, CF3, Ph-p-OMe) is described. The use of P4S10, intended to facilitate O↔S exchange, leads to the isolation of rare examples of air-stable thioester analogues of dithiooxophosphoranes. Clean heteroatom exchange can be realized using Lawesson's Reagent in good to moderate yields. Woollins' selenation reagent leads to the isolation of an unusual example of a selenazolidine product (10) in trace amounts.
Physical Exercise and Liver Autophagy: Potential Roles of IL-6 and Irisin
Authors: Pinto Ana P. , Ropelle Eduardo R. , Quadrilatero Joe , da Silva Adelino S. R.
Published: December 2021

Autophagic dysregulation contributes to liver diseases. Although some investigations have examined the effects of endurance and resistance exercise on autophagy activation, potential myokines responsible for skeletal muscle–liver crosstalk are still unknown. Based on experimental studies and bioinformatics, we hypothesized that interleukin 6 (IL-6) and irisin might be key players in the contraction-induced release of molecules that regulate liver autophagic responses.
Physical Fitness and Chemotherapy Tolerance in Patients with Early-Stage Breast Cancer
Authors: Groen Wim G. , Naaktgeboren Willeke R. , van Harten Wim H. , van Vulpen Jonna K. , Kool Nathalie , Sonke Gabe S. , van der Wall Elsken , Velthuis Miranda J. , Aaronson Neil K. , May Anne M. , Stuiver Martijn M.
Published: December 2021

Introduction

An optimal relative dose intensity (RDI) of adjuvant chemotherapy is associated with better survival in patients with breast cancer. Little is known about the role of physical fitness in attaining an adequate RDI in patients with early-stage breast cancer. We investigated the association between pretreatment physical fitness and RDI in this population.

Methods

We pooled individual patient data from two randomized exercise trials that studied exercise programs in early breast cancer: the Physical Exercise During Adjuvant Chemotherapy Effectiveness Study (n = 230) and the Physical Activity during Chemotherapy Treatment (n = 204) study. Logistic regression models were used to evaluate the association between pretreatment fitness and achieving an optimal RDI (≥85%). In addition, we added an interaction term to the model to explore the potential moderating effect of participating in an exercise program.

Results

Data were available for 419 patients (mean age at diagnosis, 50.0 ± 8.6 yr). In the total sample, lower pretreatment physical fitness was associated with significantly lower odds of achieving ≥85% RDI: age-adjusted odds ratio (OR) of 0.66 (95% confidence interval (CI), 0.46–0.94). In patients allocated to the supervised exercise intervention during chemotherapy (n = 173), the association between pretreatment physical fitness and RDI was almost completely mitigated (OR, 0.95 (95% CI, 0.54–1.56)), whereas it was more pronounced in patients who received care as usual (n = 172; OR, 0.31 (95% CI, 0.13–0.63); P
interaction = 0.022).

Conclusions

Early-stage breast cancer patients with relatively lower levels of pretreatment physical fitness have lower odds of achieving an optimal dose of chemotherapy. Given that physical fitness is modifiable and our results suggest that following a moderate-to-high intensity exercise training during chemotherapy could improve treatment completion, clinicians should not refrain from referring patients to supportive exercise programs because of low fitness.
Counterfactuals with Latent Information
Authors: Bergemann Dirk , Brooks Benjamin , Morris Stephen
Published: December 2021

We describe a methodology for making counterfactual predictions in settings where the information held by strategic agents and the distribution of payoff-relevant states of the world are unknown. The analyst observes behavior assumed to be rationalized by a Bayesian model, in which agents maximize expected utility, given partial and differential information about the state. A counterfactual prediction is desired about behavior in another strategic setting, under the hypothesis that the distribution of the state and agents’ information about the state are held fixed. When the data and the desired counterfactual prediction pertain to environments with finitely many states, players, and actions, the counterfactual prediction is described by finitely many linear inequalities, even though the latent parameter, the information structure, is infinite dimensional. (JEL D44, D82, D83)
Insider Trading and Sabotage
Authors: Evans Anthony
Published: December 2021

Insider trading is widely reviled, and yet – as Smith and Block argue – it is consistent with the basic principles of a free market system. This article draws attention to an argument against insider trading that Smith and Block don’t address, namely the potential for sabotage. However, this issue still fails to justify insider-trading legislation, and thus ultimately supports Smith and Block’s view that regulatory attempts to prevent it are misplaced.
Letting Logos Speak: Leveraging Multiview Representation Learning for Data-Driven Branding and Logo Design
Authors: Dew Ryan , Ansari Asim , Toubia Olivier
Published: December 2021

The authors develop a decision support system for design and branding based on a multimodal variational autoencoder that merges image, text, and ratings data.
The Value of Verified Employment Data for Consumer Lending: Evidence from Equifax
Authors: Chan Tat , Hamdi Naser , Hui Xiang , Jiang Zhenling
Published: December 2021

The availability of digitally verifiable employment data significantly expands credit access for economically disadvantaged customers, and at the same time, profitably expands lenders’ loan portfolio.
Resenha - Método de Caso
Authors: Giacomini Gaspar
Published: December 2021

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Strong chiral response in non-collinear high harmonic generation driven by purely electric-dipole interactions
Authors: Ayuso David , Ordonez Andres F. , Decleva Piero , Ivanov Misha , Smirnova Olga
Published: December 2021

High harmonic generation (HHG) records the ultrafast electronic response of matter to light, encoding key properties of the interrogated quantum system, such as chirality. The first implementation of chiral HHG [Cireasa et al, Nat. Phys. 11, 654 (2015)10.1038/nphys3369] relied on the weak electronic response of a medium of randomly oriented chiral molecules to the magnetic component of an elliptically polarized wave, yielding relatively weak chiro-optical signals. Here we apply state-of-the-art semi-analytical modelling to show that elliptically polarized light can drive a strong chiral response in chiral molecules via purely electric-dipole interactions – the magnetic component of the wave does not participate at all. This strong chiro-optical response, which remains hidden in standard HHG experiments, can be mapped into the macroscopic far-field signal using a non-collinear configuration, creating new opportunities for imaging chiral matter and chiral dynamics on ultrafast time scales.
Scan-less machine-learning-enabled incoherent microscopy for minimally-invasive deep-brain imaging
Authors: Guo Ruipeng , Nelson Soren , Regier Matthew , Davis M. Wayne , Jorgensen Erik M. , Shepherd Jason , Menon Rajesh
Published: December 2021

Deep-brain microscopy is strongly limited by the size of the imaging probe, both in terms of achievable resolution and potential trauma due to surgery. Here, we show that a segment of an ultra-thin multi-mode fiber (cannula) can replace the bulky microscope objective inside the brain. By creating a self-consistent deep neural network that is trained to reconstruct anthropocentric images from the raw signal transported by the cannula, we demonstrate a single-cell resolution (< 10μm), depth sectioning resolution of 40 μm, and field of view of 200 μm, all with green-fluorescent-protein labelled neurons imaged at depths as large as 1.4 mm from the brain surface. Since ground-truth images at these depths are challenging to obtain in vivo, we propose a novel ensemble method that averages the reconstructed images from disparate deep-neural-network architectures. Finally, we demonstrate dynamic imaging of moving GCaMp-labelled C. elegans worms. Our approach dramatically simplifies deep-brain microscopy.
Improvement of spatial resolution in photoacoustic microscopy using transmissive adaptive optics with a low-frequency ultrasound transducer
Authors: Notsuka Yusuke , Kurihara Makoto , Hashimoto Nobuyuki , Harada Yoshinori , Takahashi Eiji , Yamaoka Yoshihisa
Published: December 2021

Maintaining a high spatial resolution in photoacoustic microscopy (PAM) of deep tissues is difficult due to large aberration in an objective lens with high numerical aperture and photoacoustic wave attenuation. To address the issue, we integrate transmission-type adaptive optics (AO) in high-resolution PAM with a low-frequency ultrasound transducer (UT), which increases the photoacoustic wave detection efficiency. AO improves lateral resolution and depth discrimination in PAM, even for low-frequency ultrasound waves by focusing a beam spot in deep tissues. Using the proposed PAM, we increased the lateral resolution and depth discrimination for blood vessels in mouse ears.
THz generation by two-color laser air plasma coupled to antiresonance hollow-core sapphire waveguides: THz-wave delivery and angular distribution management
Authors: Katyba G. M. , Chizhov P. A. , Kurlov V. N. , Dolganova I. N. , Garnov S. V. , Zaytsev K. I. , Bukin V. V.
Published: December 2021

In this paper, hollow-core antiresonance sapphire waveguides were applied to guide the THz radiation emitted by the two-color laser air plasma, as well as to manage the THz source angular distribution. For this aim, three distinct waveguides were developed. Each of them is based on a cylindrical sapphire tube, either suspended in free space or coated by a polymer. The waveguides were first studied numerically, using the finite-difference eigenmode method, and experimentally, using the in-house THz pulsed spectrometer. The observed data uncovered the antiresonance regime of their operation, as well as their ability to guide broadband THz pulses over tens of centimeters with a high optical performance. The waveguides were then used to couple and guide (over the considerable distance) of THz radiation from the in-house two-color laser air plasma emitter, that exploits the mJ-energy-level femtosecond pulses of a Ti-sapphire laser. Small dispersion of a THz pulse and low-to-moderate propagation loss in the developed waveguide were observed, along with a considerable narrowing of the THz radiation angular distribution after passing the waveguide. Our findings revealed that such technologically-reliable hollow-core sapphire waveguides can boost the performance of laser air plasma-based THz emitters and make them more suitable for applications in the vigorously-explored THz sensing and exposure technologies.
Fourier ptychographic dark field x-ray microscopy
Authors: Carlsen Mads , Ræder Trygve M , Yildirim Can , Rodriguez-Lamas Raquel , Detlefs Carsten , Simons Hugh
Published: December 2021

Dark-field x-ray microscopy (DFXM) is an x-ray imaging technique for mapping three-dimensional (3D) lattice strain and rotation in bulk crystalline materials. At present, these maps of local structural distortions are derived from the raw intensity images using an incoherent analysis framework. In this work, we describe a coherent, Fourier ptychographic approach that requires little change in terms of instrumentation and acquisition strategy, and may be implemented on existing DFXM instruments. We demonstrate the method experimentally and are able to achieve quantitative phase reconstructions of thin film samples and maps of the aberrations in the objective lens. The method holds particular promise for the characterization of crystalline materials containing weak structural contrast.
Reconstruction and calibration methods for a Mueller channeled spectropolarimeter
Authors: Zhou Guodong , Li Yanqiu , Liu Ke
Published: December 2021

Channeled spectropolarimeter (CSP) measures spectrally resolved Stokes vector of light and Mueller matrix of sample from a snapshot. While reconstruction and calibration methods for Stokes CSP have been well established, their Mueller CSP counterparts are lacking. In this paper, we propose methods for Mueller spectrum reconstruction and Mueller CSP calibration. Mueller CSP is modeled as a modulation matrix, linking the Mueller spectrum to be measured and the modulated spectrum from the spectrometer. We describe an optimization problem to solve the Mueller spectrum, where both the regularizer and the residual threshold constrain the result, making our reconstruction accurate, efficient, and noise-robust. The Stokes spectrum generated by polarization state generator and the analyzing vector of polarization state analyzer are measured in situ, the convolution of which construct the calibrated modulation matrix of Mueller CSP. Total polarimetric errors and spectroscopic errors are treated as a whole and represented by the calibrated modulation matrix. Both imaging and non-imaging Mueller CSP are experimentally calibrated. Reconstruction results show high accuracy with a root-mean-square error (RMSE) of 0.0371. The proposed methods help make Mueller CSP practical and have the potential to be general reconstruction and calibration methods for imaging and non-imaging Stokes-Mueller CSP.
Twisted sinc-correlation Schell-model beams
Authors: Zhou Yujie , Zhu Weiting , Zhao Daomu
Published: December 2021

We introduce a new class of twisted sinc-correlation Schell-model (TSCSM) beams and analyze the statistical characteristics of such novel sources during propagation. Several typical examples are given to specifically explore the distribution and twist effect of spectral density and degree of coherence (DOC). It is shown that the irradiance profile of light intensity always rotates to 90 degree. With appropriate light field adjustment, twist effect of DOC would be diverse. DOC can exhibit unidirectional or non-unidirectional rotation during propagation. Besides, the twist factor can make the spot show a tendency to split. And beam width and coherence length also have an impact on this splitting phenomenon of spectral density.
A genome-wide CRISPR screen identifies interactors of the autophagy pathway as conserved coronavirus targets
Authors: Kratzel Annika , Kelly Jenna N. , V’kovski Philip , Portmann Jasmine , Brüggemann Yannick , Todt Daniel , Ebert Nadine , Shrestha Neeta , Plattet Philippe , Staab-Weijnitz Claudia A. , von Brunn Albrecht , Steinmann Eike , Dijkman Ronald , Zimmer Gert , Pfaender Stephanie , Thiel Volker
Published: December 2021

Over the past 20 years, 3 highly pathogenic human coronaviruses (HCoVs) have emerged—Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV), Middle East Respiratory Syndrome Coronavirus (MERS-CoV), and, most recently, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)—demonstrating that coronaviruses (CoVs) pose a serious threat to human health and highlighting the importance of developing effective therapies against them. Similar to other viruses, CoVs are dependent on host factors for their survival and replication. We hypothesized that evolutionarily distinct CoVs may exploit similar host factors and pathways to support their replication cycles. Herein, we conducted 2 independent genome-wide CRISPR/Cas-9 knockout (KO) screens to identify MERS-CoV and HCoV-229E host dependency factors (HDFs) required for HCoV replication in the human Huh7 cell line. Top scoring genes were further validated and assessed in the context of MERS-CoV and HCoV-229E infection as well as SARS-CoV and SARS-CoV-2 infection. Strikingly, we found that several autophagy-related genes, including TMEM41B, MINAR1, and the immunophilin FKBP8, were common host factors required for pan-CoV replication. Importantly, inhibition of the immunophilin protein family with the compounds cyclosporine A, and the nonimmunosuppressive derivative alisporivir, resulted in dose-dependent inhibition of CoV replication in primary human nasal epithelial cell cultures, which recapitulate the natural site of virus replication. Overall, we identified host factors that are crucial for CoV replication and demonstrated that these factors constitute potential targets for therapeutic intervention by clinically approved drugs.
Asymmetric and transient properties of reciprocal activity of antagonists during the paw-shake response in the cat
Authors: Parker Jessica R. , Klishko Alexander N. , Prilutsky Boris I. , Cymbalyuk Gennady S.
Published: December 2021

Mutually inhibitory populations of neurons, half-center oscillators (HCOs), are commonly involved in the dynamics of the central pattern generators (CPGs) driving various rhythmic movements. Previously, we developed a multifunctional, multistable symmetric HCO model which produced slow locomotor-like and fast paw-shake-like activity patterns. Here, we describe asymmetric features of paw-shake responses in a symmetric HCO model and test these predictions experimentally. We considered bursting properties of the two model half-centers during transient paw-shake-like responses to short perturbations during locomotor-like activity. We found that when a current pulse was applied during the spiking phase of one half-center, let’s call it #1, the consecutive burst durations (BDs) of that half-center increased throughout the paw-shake response, while BDs of the other half-center, let’s call it #2, only changed slightly. In contrast, the consecutive interburst intervals (IBIs) of half-center #1 changed little, while IBIs of half-center #2 increased. We demonstrated that this asymmetry between the half-centers depends on the phase of the locomotor-like rhythm at which the perturbation was applied. We suggest that the fast transient response reflects functional asymmetries of slow processes that underly the locomotor-like pattern; e.g., asymmetric levels of inactivation across the two half-centers for a slowly inactivating inward current. We compared model results with those of in-vivo paw-shake responses evoked in locomoting cats and found similar asymmetries. Electromyographic (EMG) BDs of anterior hindlimb muscles with flexor-related activity increased in consecutive paw-shake cycles, while BD of posterior muscles with extensor-related activity did not change, and vice versa for IBIs of anterior flexors and posterior extensors. We conclude that EMG activity patterns during paw-shaking are consistent with the proposed mechanism producing transient paw-shake-like bursting patterns found in our multistable HCO model. We suggest that the described asymmetry of paw-shaking responses could implicate a multifunctional CPG controlling both locomotion and paw-shaking.
Combination treatment optimization using a pan-cancer pathway model
Authors: Schmucker Robin , Farina Gabriele , Faeder James , Fröhlich Fabian , Saglam Ali Sinan , Sandholm Tuomas
Published: December 2021

The design of efficient combination therapies is a difficult key challenge in the treatment of complex diseases such as cancers. The large heterogeneity of cancers and the large number of available drugs renders exhaustivein vivoor evenin vitroinvestigation of possible treatments impractical. In recent years, sophisticated mechanistic, ordinary differential equation-based pathways models that can predict treatment responses at amolecularlevel have been developed. However, surprisingly little effort has been put into leveraging these models to find novel therapies. In this paper we use for the first time, to our knowledge, a large-scale state-of-the-art pan-cancer signaling pathway model to identify candidates for novel combination therapies to treat individual cancer cell lines from various tissues (e.g., minimizing proliferation while keeping dosage low to avoid adverse side effects) and populations of heterogeneous cancer cell lines (e.g., minimizing the maximum or average proliferation across the cell lines while keeping dosage low). We also show how our method can be used to optimize the drug combinations used insequentialtreatment plans—that is, optimized sequences of potentially different drug combinations—providing additional benefits. In order to solve the treatment optimization problems, we combine the Covariance Matrix Adaptation Evolution Strategy (CMA-ES) algorithm with a significantly more scalable sampling scheme for truncated Gaussian distributions, based on a Hamiltonian Monte-Carlo method. These optimization techniques are independent of the signaling pathway model, and can thus be adapted to find treatment candidates for other complex diseases than cancers as well, as long as a suitable predictive model is available.
A novel theoretical framework for simultaneous measurement of excitatory and inhibitory conductances
Authors: Müller-Komorowska Daniel , Parabucki Ana , Elyasaf Gal , Katz Yonatan , Beck Heinz , Lampl Ilan
Published: December 2021

The firing of neurons throughout the brain is determined by the precise relations between excitatory and inhibitory inputs, and disruption of their balance underlies many psychiatric diseases. Whether or not these inputs covary over time or between repeated stimuli remains unclear due to the lack of experimental methods for measuring both inputs simultaneously. We developed a new analytical framework for instantaneous and simultaneous measurements of both the excitatory and inhibitory neuronal inputs during a single trial under current clamp recording. This can be achieved by injecting a current composed of two high frequency sinusoidal components followed by analytical extraction of the conductances. We demonstrate the ability of this method to measure both inputs in a single trial under realistic recording constraints and from morphologically realistic CA1 pyramidal model cells. Future experimental implementation of our new method will facilitate the understanding of fundamental questions about the health and disease of the nervous system.
Dissociable influences of reward and punishment on adaptive cognitive control
Authors: Leng Xiamin , Yee Debbie , Ritz Harrison , Shenhav Amitai
Published: December 2021

To invest effort into any cognitive task, people must be sufficiently motivated. Whereas prior research has focused primarily on how the cognitive control required to complete these tasks is motivated by the potential rewards for success, it is also known that control investment can be equally motivated by the potential negative consequence for failure. Previous theoretical and experimental work has yet to examine how positive and negative incentives differentially influence the manner and intensity with which people allocate control. Here, we develop and test a normative model of control allocation under conditions of varying positive and negative performance incentives. Our model predicts, and our empirical findings confirm, that rewards for success and punishment for failure should differentially influence adjustments to the evidence accumulation rate versus response threshold, respectively. This dissociation further enabled us to infer how motivated a given person was by the consequences of success versus failure.