bluuebunny/crossref_metadata_2025 huggingface dataset:
Long COVID, the Mysterious Disease: A Role for Cannabidiol?
Authors:   Clinical Investigation Support Gmbh, Nahler Gerhard
Published: April 2022

Long COVID is a mysterious condition characterised by a plethora of symptoms lasting 3 months but usually longer after the onset of the acute infection. Although its cause and mechanisms are still incompletely understood, current hypotheses favour an immunopathological nature leading to a multi-inflammatory, multi-organ syndrome that can persist for months or even years. It seems to be fuelled by persisting and/or newly formed antigens that trigger inflammatory responses at the side of tissue attacks by antigens. An impressive number of patients complain symptoms related to the nervous system such as chronic fatigue, concentration/memory/cognitive deficit, anxiety, Post-Traumatic Stress Disorder (PTSD), depression, sleep abnormalities and the like. Cannabidiol (CBD) is a substance that easily crosses also the intact blood-brain barrier, has anti-inflammatory properties and demonstrated immunomodulating effects in various immunopathological conditions. Although human experiences in Long COVID are still missing, CBD seems to be a promising substance.
Encapsulación y etiquetas discursivas en el discurso parlamentario: función argumentativa a partir de un corpus paralelo
Authors: Izquierdo Alegría Dámaso , González Ruiz Ramón
Published: April 2022

Las lenguas disponen de variados mecanismos de cohesión textual. Uno de ellos, que aquí, en ausencia de unanimidad en la terminología, denominaremos encapsulación nominal, permite sintetizar, mediante sintagmas nominales, fragmentos discursivos de diferente extensión y complejidad conceptual. Con base en un corpus de discursos parlamentarios, en este trabajo pretendemos ofrecer un análisis cualitativo acerca de la traducción de este mecanismo cohesivo en un corpus de intervenciones parlamentarias extraído del corpus paralelo Europarl5 (Koehn, 2005). Este corpus contiene los discursos pronunciados en el Parlamento Europeo entre los años 1996 y 2009 y sus traducciones a once lenguas (danés, alemán, griego, inglés, español, finés, francés, italiano, holandés, portugués y sueco). Para este estudio se ha tenido en cuenta únicamente el español como fuente de los textos meta y algunas de las principales lenguas europeas (especialmente inglés, francés, alemán, italiano) como fuente de los textos origen. Los resultados obtenidos revelan que un generoso número de las transformaciones encontradas en el corpus son explicitaciones, lo cual implica cambios en la carga valorativa del encapsulador y, en consecuencia, en el tenor argumentativo. Estos “desajustes” entre los textos origen y los textos meta parecen producirse con mucha frecuencia, según señalan algunos estudios previos.
Legality of University' Students Behavior
Authors: Sokolova Marina Vladimirovna , Listratov Ivan Vadimovich , Petrosyan Dmitrii Il'ich
Published: April 2022

The subject of the study is the legality of students' behavior in Vladimir branch of the RANEPA (University). The students under conducted research were chosen form economic, managerial and legal departments of University. The author examines in detail such aspects of the topic as: the permissibility of violating laws in the mass consciousness of students, the reasons for committing illegal acts and the factors that deter from violating the law. The work also reveals such aspects of the problem as: the frequency of applying to specialists for legal assistance, the main difficulties faced by young people in obtaining and applying legal information, the reasons for refusing to protect their own rights. Special attention is paid to the specialty of legal behavior of students from law department of University. As a result of the study, the following conclusions were obtained: ignorance of the law often leads to the commission of illegal actions, there is also a psychological nature of offenses when a crime is committed under the influence of feelings, emotions or "illegal acts committed for friendship". There are professional features of legal behavior. Students studying in the specialty "Judicial and prosecutorial activity" are more likely than others to think about preserving their positive reputation. A significant part of respondents are poorly oriented in the sources of obtaining legal information and do not always understand where to turn for help. A fifth of all respondents do not defend their rights. There is still a fairly high level of distrust towards the police.
Internal Temporal Structure of the Biblical Hebrew Verb: A Case Study of Lexical Aspect in the Verb yd'
Authors: Sato Jun
Published: April 2022

Traditional Biblical Hebrew (BH) grammars have often defined the temporal information of BH verbs only in terms of tense or grammatical aspect, which can be identified by the finite verbal forms. This paper argues that lexical aspect, which is also known as situation aspect or Aktionsart, is an essential semantic factor for determining the internal temporal structure of BH predicates. As a trial cut, this paper analyses lexical aspect in the verb yd' in the qatal, qotel, and wayyiqtol forms.
Chair of Physical and Technical Informatics of the Physics Department at Novosibirsk State University
Authors: Glushak A. A.
Published: April 2022

The Chair of Physics and Technology of the Physics Department trains specialists in the field of software and hardware for physical experiments, storage, and processing of information. The program of the courses involves the study of programming methods, information technologies and hardware for experimental installations in addition to fundamental education in physics and mathematics, which all students of the physics department of NSU receive. The graduates of the chair are specialists in the field of information technology with universal general physical training.
Four-Quark Nature of Light Scalar Mesons
Authors: Achasov N. N.
Published: April 2022

The contribution of Novosibirsk physicists to the discovery of the four-quark nature of light scalar mesons f0(980) and a0(980) is described.
Investigation of Transverse Instability of a High-Current Relativistic Electron Beam in a Linear Induction Accelerator
Authors: Sandalov E. S. , Sinitsky S. L. , Skovorodin D. I. , Nikiforov D. A. , Logachev P. V. , Bak P. A. , Zhivankov K. I. , Kenzhebulatov E. K. , Petrenko A. V. , Nikitin O. A. , Akhmetov A. R. , Protas R. V. , Khrenkov S. D. , Zhuravlev I. A. , Penzin I. V. , Don A. R.
Published: April 2022

The article presents the results of studies on the transverse instability of a high-current relativistic electron beam developing in a linear induction accelerator LIA for 5 MeV electron energy, which is created at the BINP SB RAS together with RFNC VNIITF. These results were obtained using a software package that makes it possible to simulate the dynamics of the instability development, as well as to calculate the increment of this instability averaged over the accelerator length. The package consists of four main parts. The first of them, made on the base of a three-dimensional model of the accelerating module electrodynamic system of the LIA, allows calculating the main characteristics of electromagnetic dipole modes of such a module, the second and third parts are designed to find three-dimensional accelerating electric and focusing magnetic fields, respectively. In the last part of the package, a system of ordinary differential equations is solved that describes both the motion of beam macroparticles in electric and magnetic fields, including the eigenmode fields, and the excitation of the mode fields by the electron beam. The adequacy of the physical models used in the software package was tested by comparing the spectra of field oscillations in the accelerator modules obtained in calculations and recorded in the experiment. On the base of the data obtained, the main regularities of the transverse beam instability development in the frequency range ∆f = 0.3–1.1 GHz were revealed, and possible methods for suppressing this instability in the LIA were proposed.
Modern server ARM processors for supercomputers: A64FX and others. Initial data of benchmarks
Authors: Kuzminsky Mikhail Borisovich
Published: April 2022

A comparative analysis of the performance of ARM server processors used on supercomputers or also aimed at high-performance computing (HPC) is given. Fujitsu A64FX, Marvell ThunderX2 and Huawei Kunpeng 920 were selected for the initial performance analysis. The HPC performance review focuses primarily on benchmarks and applications for the A64FX, which supports longer vectors than other ARM processors and has higher peak performance. The performance of the A64FX is compared against corresponding data for Intel Xeon Skylake and Cascade Lake, and AMD EPYC with Zen 2 and 3 (Roma and Milan), as well as Nvidia V100 and A100 GPUs. A short set of potential pros and cons of the A64FX microarchitecture has been formulated. Comparison of performance data obtained using different compilers for A64FX. Features have been formed when A64FX usually gives advantages in performance over x86-64, and when it concedes to x86-64.

It is clear that the use of A64FX in supercomputers can grow further. There is an assumption that x86-64 hegemony in HPC will decrease, in particular, due to the increased use of server ARM processors. But the analysis of A64FX and new AArch64 processors expected in the near future showed that A64FX will not necessarily lead in this process.
Robust algorithmic binding to arbitrary fragment of program code
Authors: Goloveshkin Alexey V. , Mikhalkovich Stanislav S.
Published: April 2022

When solving a task, a programmer actively interacts with a finite set of code fragments. The information about their locations is important for quick navigation, for other developers, and as a kind of documentation. Integrated development environments (IDEs) provide tools for marking code fragments with labels, displaying lists of labels, and using these labels for quick navigation. However, they often lose the correspondence between the label and the marked place when the code is edited, in particular when changes are made outside the IDE.

In previous works, the authors propose a tool to be integrated into various IDEs for “binding” to large syntactic entities of a program and building a markup that is robust to code editing. The description of the marked element is built on the basis of the abstract syntax tree (AST) of the program. Later it is used to algorithmically search for the element in an edited code. The search has a success rate from 99 to 100%.

This article aims at robust algorithmic binding to an arbitrary section of the code. For binding to a single-line code fragment, we propose an extension of the model describing the marked fragment, and an additional search algorithm. We also propose an algorithm for embedding nodes corresponding to multi-line fragments in an AST. We show that the correctness of the AST is not violated by these embeddings. Bindings to randomly selected lines were made in the code of three large C# projects. Manual check of these lines search results in the edited code has confirmed that the bindings are robust to code editing.
Chronic respiratory disease in low-income and middle-income countries: From challenges to solutions
Authors: Meghji Jamilah , Jayasooriya Shamanthi , Khoo Ee Ming , Mulupi Stephen , Mortimer Kevin
Published: April 2022

In 2019, the British Thoracic Society (BTS) launched a Global Health Group in partnership with the Pan African Thoracic Society (PATS). Each year, this group proposes a symposium at the BTS Winter meeting exploring issues of respiratory disease and care which are most relevant to respiratory health across the life course in low- and middle-income countries (LMICs). The first symposium, offered in February 2021, described the burden of five key respiratory exposures/diseases of interest in LMICs, including childhood pneumonia, air pollution, post-TB lung diseases, asthma, and chronic obstructive pulmonary disease, and a summary of the discussion has previously been published in the PATS journal. The second symposium, conducted in November 2021, discussed barriers to the management of chronic respiratory diseases (CRDs) in LMICs, with perspectives presented from Malaysia, The Gambia, Kenya, and sub-Saharan Africa more broadly. These presentations highlighted the challenges of chronic respiratory care in LMICs, while a presentation from the World Health Organization (WHO) officer for CRDs described the role and remit of the WHO in providing leadership and guidance in this area. A summary of this second symposium is presented here, and we discuss the pathways from challenges to solutions for CRD care in low- and middle-income countries.
Psychological challenges and coping strategies of quarantined healthcare workers exposed to confirmed COVID-19 cases in a tertiary hospital in Edo state
Authors: Mokogwu Ndubuisi
Published: April 2022

Objectives:

Healthcare workers (HCWs) face a significant risk of exposure to the new SARS-CoV-2 virus due to its high infectivity. This study aimed to determine the mental health consequences of quarantine and the coping strategies used by quarantined healthcare workers (HCW) at the University of Benin Teaching Hospital (UBTH).

Materials and Methods:

This was a cross-sectional survey of 32 HCWs quarantined due to exposure to confirmed case of COVID-19. The primary outcome variables were the frequency of depression, anxiety, and anxiety-depression. Data was collected with the use of a self-administered questionnaire adapted from the patient health questionnaire-9 and the general anxiety disorder-7 questionnaires respetively.

Results:

There were 32 quarantined health workers with a mean ± SD age of 32.4 ± 8.4 years, and 59.4% were female. Twenty-three (71.9%) had spent <5 years in service. Doctors and nurses made up an equal proportion of 46.9% of the respondents, respectively. The prevalence of anxiety, depression, and anxiety-depression was 9.4%, 12.5%, and 9.4%, respectively. Coping measures employed by the health workers centered on preventing boredom and improving communication.

Conclusion:

There was a low frequency of anxiety, depression, and anxiety-depression in HCWs who were quarantined as a result of exposure to COVID-19. Health-care managers need to support the establish formal workplace mental health programs to support the psychological well-being of all staff.
Blepharitis
Authors:   The S. Fyodorov Eye Microsurgery Federal State Institution, the Tambov branch, Tambov, Russia, Manaenkova G. E. , Fabrikantov O. L. ,   The S. Fyodorov Eye Microsurgery Federal State Institution, the Tambov branch, Tambov, Russia, Lev I. V. ,   The S. Fyodorov Eye Microsurgery Federal State Institution, the Tambov branch, Tambov, Russia, Matrosova Y. V. ,   The S. Fyodorov Eye Microsurgery Federal State Institution, the Tambov branch, Tambov, Russia, Goidin A. P. ,   The S. Fyodorov Eye Microsurgery Federal State Institution, the Tambov branch, Tambov, Russia, Tovmach L. N. ,   The S. Fyodorov Eye Microsurgery Federal State Institution, the Tambov branch, Tambov, Russia
Published: April 2022

Пособие содержит теоретические материалы о блефаритах, особенностях клинических форм, методов обследования и лечения блефаритов. Материал изложен в соответствии с государственным стандартом, является дополнением учебника и лекционного курса для студентов, ординаторов и врачей-офтальмологов.
Endocytosis of coacervates into liposomes
Authors: Lu Tiemei , Liese Susanne , Schoenmakers Ludo , Weber Christoph , Suzuki Hiroaki , Huck Wilhelm , Spruijt Evan
Published: April 2022

Recent studies have shown that the interactions between condensates and biological membranes is of functional importance. Here, we study how the interaction between complex coacervates and liposomes as model systems can lead to membrane deformation and endocytosis. Depending on the interaction strength between coacervates and liposomes, the wetting behavior ranged from non-wetting, to partial wetting (adhesion), engulfment (endocytosis), and finally complete wetting. Endocytosis of coacervates was found to be a general phenomenon: coacervates made from a wide range of components could be taken up by liposomes. A simple theory that takes into account surface energies and coacervate sizes can explain the observed coacervate-liposome interactions. Our findings can help to better understand condensate-membrane interactions in cellular systems and provide new avenues for intracellular delivery using coacervates.
Analysis of the dynamics of mortality from respiratory diseases in the Russian Federation for 2019–2020
Authors: Drapkina Oksana M. , Samorodskaya Irina V. , Bolotova Elena V. , Dudnikova Anna V.
Published: April 2022

Aim. To study the dynamics and contribution of mortality from Diseases of the respiratory system (DRS) in 2019 and 2020 to mortality from all causes with and without deaths from COVID-19 in 82 regions of the Russian Federation.
Materials and methods. The data provided by Rosstat for 2019 and 2020 on the average annual population and the number of deaths due to causes of DRS (class J00J99) were used the standardised death rate (SDR) were calculated, the regional average value, standard deviation and coefficient of variation.
Results. The average increase in the SDR from DRS in 2020 was 22.1913.22 per 100 thousand population (66.4489.6% higher than in 2019). The average regional SDR from DRS + COVID-19 in 2020 was higher than the SDR from DRS in 2019 by 87.6530.1 per 100 thousand population. The average regional share of SDR in the structure of mortality excluding COVID-19 increased from 3.661.44 to 5.062.49%; taking into account COVID-19, it increased to 10.963.13%. In 16 regions, the SDR from DRS + COVID-19 exceeded the increase in mortality from all causes. No correlation was found between SDR (2020) from all causes and SDR from COVID-19 (r=0.09; p=0.39); an inverse correlation was found between SDR from DRS and SDR from COVID-19 in 2020 (r=-0.42; p0.0001).
Conclusion. Against the background of high interregional variability of SDR from DRS in most regions, an increase in the mortality rate from DRS and the contribution of DRS to total mortality in 2020 was registered.
Principles of modern diagnosis and treatment of atopic dermatitis and bronchial asthma: Clinical case
Authors: Shogenova Madina S. , Hutueva Svetlana H. , Shogenova Laura S.
Published: April 2022

This article presents the experience of successful use of the drug dupilumab in a patient with severe atopic dermatitis and bronchial asthma. The effectiveness of biological therapy with dupilumab 300 mg subcutaneously for 52 weeks of T-2 associated diseases, including a combination of severe atopic dermatitis and bronchial asthma, uncontrolled course based on the case history of patient Ts., born in 2006 with the diagnosis "Main: atopic dermatitis, common form, severe course. Concomitant diagnosis: bronchial asthma, persistent course, uncontrolled, moderate severity". Dynamic monitoring of the total blood count with the calculation of the absolute number of eosinophils in peripheral blood was performed. The study showed high efficacy and safety of biological therapy with dupilumab 300 mg subcutaneously every 2 weeks for 52 weeks with a combination of severe atopic dermatitis and bronchial asthma, uncontrolled course in patient Ts (Born in 2006). The examination of the ALEX2 allergochip made it possible to establish the molecular components of the primary causal allergens, predict the course of an allergic disease, and carry out successful elimination measures against food allergens, preserving the maximum set of nutrients in the patient's diet. Dupilumab therapy in severe atopic dermatitis and uncontrolled bronchial asthma leads to clinically significant improvement in the course of diseases, control of disease symptoms. Atopic dermatitis shows a decrease in itching of the skin, normalization of sleep, improvement of quality of life. With bronchial asthma, a reduction in exacerbations, normalization of respiratory function indicators, complete control of the disease has been achieved. The targeted biological drug dupilumab has a targeted effect on the key links in the pathogenesis of atopic dermatitis and bronchial asthma and reduces the burden of severe diseases. Therefore, the use of dupilumab in atopic dermatitis and bronchial asthma contributes to achieving disease control and improving the patient's quality of life.
Collagen-associated side effects of fluoroquinolones: aneurysm and aortic dissection (systematic review)
Authors: Leonova Marina V.
Published: April 2022

Well known for fluoroquinolones cause the development of collagen-associated side effects tendopathies with the risk of tendon rupture and retinal detachment, which is associated with the damaging effect and degradation of type I and type III collagen. The aorta is also rich in collagen type I and type III up to 8090%, which has the potential to play a role in the development of aortopathies in cases of fluoroquinolone use. Since 2015, the first publications of research results on the collagen-associated effect of fluoroquinolones on the development of aneurysm and aortic dissection, often called aortopathy, began to appear. A systematic review of observational studies and 5 meta-analyzes of the development of a novel side effect of fluoroquinolones is presented. An absolute incidence of this side effect of 1.1% and a twofold increased relative risk of developing aneurysm/aortic dissection (RR 2.042.23), aortic aneurysm (RR 1.742.83), and aortic dissection (RR 1.882.79). When analyzing age subgroups, an increase in the risk of aneurysm/aortic dissection was noted already from the age of 35 years and was more significant in elderly patients (over 65 years). Analisys of the course duration of fluoroquinolone use (314 days or 14 days) was carried out in two studies and showed an increase in the risk of aneurysm/aortic dissection with increasing duration of fluoroquinolone therapy (RR 1.72 versus RR 1.92). The risk of developing a fluoroquinolone-associated aortopathy was highest during the first 30 days after the course use of fluoroquinolones, with a slight decrease within 6090 days after the course. The signal was confirmed by the FDA pharmacovigilance system (USA) during the analysis of cases of aneurysm/aortic dissection against the background of fluoroquinolones use. International regulatory authorities (FDA and EMA) have announced official documents warning of an increased incidence of rare but serious cases of aortic dissection or ruptured aortic aneurysm with oral fluoroquinolones. Fluoroquinolones should not be given to patients at increased risk unless other treatment options are available. The increased risk category includes patients with a history of aortic or other blood vessel aneurysm, high blood pressure, and the elderly.
Horse Chestnut Extract. Update-2022
Authors: Bogachev Vadim Yu. , Boldin Boris V. , Turkin Pavel Yu.
Published: April 2022

Horse chestnut is known as a venotonizing agent of plant origin. The main active ingredient of chestnut common extract is aescin. It has anti-edema, anti-inflammatory and venotonizing properties. The aescin medicinal agent should be used for chronic vein disease, hemorrhoidal disease and post-traumatic edema. The pharmacological properties of chestnut horse extract allow the inclusion of medications based on it in the rehabilitation program of patients who have suffered a new coronavirus infection (COVID-19).
SMN-deficient cells exhibit increased ribosomal DNA damage
Authors: Karyka Evangelia , Berrueta Ramirez Nelly , Webster Christopher P , Marchi Paolo M , Graves Emily J , Godena Vinay K , Marrone Lara , Bhargava Anushka , Ray Swagat , Ning Ke , Crane Hannah , Hautbergue Guillaume M , El-Khamisy Sherif F , Azzouz Mimoun
Published: April 2022

Spinal muscular atrophy, the leading genetic cause of infant mortality, is a motor neuron disease caused by low levels of survival motor neuron (SMN) protein. SMN is a multifunctional protein that is implicated in numerous cytoplasmic and nuclear processes. Recently, increasing attention is being paid to the role of SMN in the maintenance of DNA integrity. DNA damage and genome instability have been linked to a range of neurodegenerative diseases. The ribosomal DNA (rDNA) represents a particularly unstable locus undergoing frequent breakage. Instability in rDNA has been associated with cancer, premature ageing syndromes, and a number of neurodegenerative disorders. Here, we report that SMN-deficient cells exhibit increased rDNA damage leading to impaired ribosomal RNA synthesis and translation. We also unravel an interaction between SMN and RNA polymerase I. Moreover, we uncover an spinal muscular atrophy motor neuron-specific deficiency of DDX21 protein, which is required for resolving R-loops in the nucleolus. Taken together, our findings suggest a new role of SMN in rDNA integrity.
Mg/Al-chitosan as a Selective Adsorbent in The Removal of Methylene Blue from Aqueous Solutions
Authors: Siregar Patimah Mega Syah Bahar Nur , Lesbani Aldes , Mohadi Risfidian
Published: April 2022

The use of dyes in the textile industry is detrimental to aquatic biota and humans. Pollution caused by dye waste can be overcome by adsorption methods using adsorbents such as LDH. LDH is known as an adsorbent that is often found in the process of removing dye waste, but repeated use is not effective. This can be overcome by the LDH modification process using a supporting material such as chitosan. Modification of LDH can be done using coprecipitation or precipitation simultaneously at pH 10. XRD analysis where the peaks that appear in Mg/Al-chitosan are similar to the typical peaks of the constituent materials, namely Mg/Al and chitosan. This is confirmed by FTIR analysis where the spectrum that appears in Mg/Al-chitosan is similar to the spectrum in Mg/Al and chitosan. As well as BET analysis where there is an increase in the surface area of Mg/Al after being modified to Mg/Al-chitosan from 5.845 m2/g to 24.556 m2/g. In this study, the selectivity process for the dye mixture was carried out first with the most selective dye for the Mg/Al-chitosan adsorbent was methylene blue. Methylene blue was continued for adsorption processes such as isotherm adsorption kinetics and adsorption thermodynamics as well as adsorbent regeneration studies. The results showed that at 90 minutes the adsorption reached equilibrium. The adsorption capacity of Mg/Al increased after modification using chitosan from 84.746 mg/g to 108.696 mg/g. The adsorption process follows the Langmuir isotherm type where adsorption occurs chemically (monolayer). Regeneration studies show that Mg/Al-chitosan is an adsorbent that can be used repeatedly with stable adsorption effectiveness until the fifth cycle.
Takeuti's Well-ordering Proof
Authors: Thomas-Bolduc Aaron , Darnell Eamon
Published: April 2022

G. Genzten’s 1938 proof of the consistency of pure arithmetic was hailed as a success for finitism and constructivism, but his proof requires induction along ordinal notations in Cantor normal form up to the first epsilon number, Îµ0. This left the task of giving a finitisically acceptable proof of the well-ordering of those ordinal notations, without which Gentzen’s proof could hardly be seen as a success for finitism. In his seminal book Proof Theory G. Takeuti provides such a proof. After a brief philosophical introduction, we provide a reconstruction of Takeuti’s proof including corrections, comments, re-organization and notational adjustments for the sake of clarity. The result is a much longer, but much more tractable proof of the well-ordering of ordinal notations in Cantor normal form less than Îµ0, that nevertheless follows Takeuti’s strategy closely. We end with some more general comments about that proof strategy and the notion of accessibility more generally.
Threeway Submodularity in Connectivity Functions
Authors:   , Bohanna Amber
Published: April 2022

Connectivity is a structural property of certain combinatorial objects in-cluding matroids and graphs. Connectivity functions provide a settingto prove and generalise statements regarding connectivity. A connectivityfunction is a normalized, symmetric and submodular integral set function.

We investigate the connectivity functions that satisfy a strictly strongercondition than submodularity called threeway submodularity. We deter-mine to the best of our abilities which connectivity functions satisfy thisproperty, and discuss the problem of recognizing it. We then provide amodular cut style theory for enumerating a class of connectivity functions.
DEVELOPMENT OF A ROUTING SCHEME FOR PATIENTS WITH DISEASES OF THE MUCOSA OF THE MOUTH
Authors: V.V. Shkarin , Yu.A. Makedonova , S.V. Dyachenko
Published: April 2022

Abstract. Introduction. Patients with lichen planus are a complex group that requires not only individual diagnosis and treatment of pathology, but also interdisciplinary interaction of medical specialists, a differentiated objective approach. In connection with the foregoing, is the introduction of telemedicine technologies in the routing scheme for patients with lichen planus. The purpose of the study is to evaluate the effectiveness of telemedicine technologies when they are included in the routing scheme for patients with lichen planus. Materials and methods. 29 patients with lichen planus were consulted using telemedicine technologies in the mode of deferred consultations. The following forms of lichen planus were identified: typical, exudative-hyperemic, erosive-ulcerative, hyperkeratotic, bullous, atypical. After receiving and studying the documents of patients with lichen planus, the staff of the Department of Dentistry prepared medical reports in electronic form to determine and correct the patient management scheme and recommendations for the dentist. After telemedicine consultations, this type of technology was assessed when they were included in the routing scheme for patients with lichen planus. Results and discussion. When studying the forms of lichen planus requiring consultation using telemedicine, we identified the greatest difficulty in managing a patient with erosive-ulcerative and bullous forms. The tasks of telemedicine requests were: confirmation of the diagnosis of mucosal disease, clarification of the need for laboratory methods for diagnosing the disease, discussion of the patient management scheme. Conclusion. The obtained results of remote consultation of patients with pathology of the oral mucosa confirm the effectiveness of the use of telemedicine technologies. All of the above indicates the need to optimize the routing scheme for patient data with the inclusion of a protocol for conducting telemedicine consultations.
A RETROSPECTIVE OF RESEARCH ON ERGOT ALKALOIDS
Authors: K.D. Evstratova
Published: April 2022

Abstract. Ergot is a parasitic fungus that grows on cereals, including rye and wheat. Ergot alkaloids are substances that are produced by the mycelium of the fungus of the genus Claviceps, a typical representative of which is the species Claviceps purpurea. Ergot alkaloids are derivatives of the tetracyclic compound 6-methylergoline. The ergoline backbone gives the molecules of indole alkoloids a structural similarity to biogenic amines - epinephrine, norepinephrine, dopamine and serotonin. Due to this similarity, ergot alkaloids can interact with receptors for various primary messengers. Most of the alkoloid compounds have physiological activity, some of them are also used in medicine. In general, the mechanisms of toxic and pharmacological action of ergot alkaloids and their semisynthetic derivatives are very complex and varied. They can have agonistic, partial agonistic or antagonistic effects on α-andrenoreceptors and serotonin receptors, as well as agonistic or partial agonistic effects on dopamine receptors in the central nervous system. If the ingestion of ergot alkaloids into the human body occurs uncontrollably and in relatively large doses, intoxication occurs, which causes a disease called ergotism. In the history of pharmacology, poisoning of people with these substances was quite common in medieval Europe. In obstetric practice, they tried to induce labor, but this ended in miscarriages in women. Scientists have not studied the exact dose that causes a therapeutic effect, but these problems have been eliminated in our time. They have been used in many areas of medicine for many years. The most popular drugs based on alkaloids have acquired in such specialties as gynecology and neurology. The article discusses in detail such aspects of the topic as: the structure of the substance, pharmacological effects and clinical manifestations.
RISK-ORIENTED APPROACH TO OPTIMIZATION OF PHARMACEUTICAL DEVELOPMENT PROCESS OF MEDICINAL PRODUCTS
Authors: A.E. Feofilova , A.V. Foteeva , N.B. Rostova , V.V. Loginova
Published: April 2022

Abstract. The modern regulatory requirements for pharmaceutical development, stricter of requirements of medicinal products (MP) quality standards, the experience of manufacturers and development companies in terms of MP pharmaceutical development revealed need to create solutions that minimize the risk of medicinal product quality deviations, guaranteeing the release of effective and safe MP with the planned quality.
The aim of these study is to form solutions for optimization of generic medicinal products pharmaceutical development process.
For the study, according to the proposed algorithm, a generic drug in a liquid for inhalation dosage form was developed.
The pharmaceutical development of MP according to created model contributes to reducing the financial and time costs of the developer company related to repeated research of PD, eliminating inconsistencies in the reproducibility and control of the technological process, maintaining the goals of the company's PQS in terms of the development and circulation of medicinal products, guaranteeing efficiency, safety and quality of the developed generic medicinal products.
ASSESSMENT OF DEFICIENCY OF NEUROSURGICAL OPERATIONS IN THE PERIOD OF COVID-19 PANDEMIC
Authors: V.T. Korkhmazov
Published: April 2022

Abstract. The proceeding pandemic of COVID-19 makes strong indirect impact on human health, limiting volumes of the planned surgical help to millions of patients worldwide. Is known of influence of a pandemic on volumes of surgical interventions very little. In article the short overview of influence of a pandemic COVID-19 for work of neurosurgical offices in territorial subjects of the Russian Federation is provided. COVID-19 pandemic significantly changed structure of bed fund of the country due to sharp increase in quantity of infectious beds from 57.5 thousand beds in 2015 to 210.1 thousand beds in 2020. Besides, for treatment of patients with COVID-19 in 2020 63.4 thousand specialized beds were in addition developed in 69 territorial subjects of the Russian Federation, most of all in the Moscow region – 8424 beds and in Moscow – 8117 beds. Also, as a part of intensive care units 14408 beds for an intensive care of the patients affected with a new coronavirus infection were allocated. Thus, all 259.1 thousand beds, or 25.1% of total capacities of bed fund of the round-the-clock hospitals of the country, a part of which it was reorientated, were used for treatment of the patients infected with COVID-19 in 2020 in Russia. In 2020 because of a pandemic in Russia the total deficiency of volumes of neurosurgical operations was 23.6 thousand interventions, including 4.1 thousand operations at an injury of the head and 3.2 thousand operations on removal of tumors of a brain which belong to urgent and urgent interventions. The action plan in force majeure is necessary for surgical services for ensuring availability of the surgical help in the current phase of development of a pandemic. The post-pandemic phase will demand recovery of work of surgical services and accumulation of their potential taking into account priority of delivery of health care and the collected unsatisfied need of the population for surgical treatment of diseases of a nervous system and also other morbid conditions.
YVO4:RE (RE = Eu, Tm, and Yb/Er) nanoparticles synthesized by the microwave-assisted hydrothermal method for photoluminescence application
Authors: Pinatti Ivo Mateus , De Foggi Camila Cristina , Teodoro Marcio Daldin , Longo Elson , Sim�es Alexandre Zirpoli , Rosa Ieda L�cia Viana
Published: April 2022

Here, an experimental study is presented on the YVO4:RE (RE = Eu, Tm, and Yb/Er) nanoparticles synthesized by means of the microwave-assisted hydrothermal method. Different characterization techniques (X-ray diffraction, Raman and ultraviolet-visible spectroscopy, field emission scanning electron microscopy, transmission electron microscopy, and photoluminescence emissions) have been employed to examine the structural, optical, as well as its morphology and photoluminescent properties. The as-synthetized samples present different emission colors due to RE3+ ions, as well as nanosized spherical morphology because of synthesis method. These materials can be considered efficient materials for optical devices.
Activated carbon from pumpkin seeds: Production by simultaneous carbonization activation for occupational respiratory protection
Authors: Silva Walqu�ria Joseane , Andrade Neto Nivaldo Freire , Paskocimas Carlos Alberto , Ruiz Juan Alberto Chaves , Carvalho Fab�ola Correa , Longo Elson , Da Motta Fabiana Villela , Delmonte Maur�cio Roberto Bomio
Published: April 2022

Activated carbon materials are derived from carbonaceous sources and used as a technological element for various industrial purposes. These materials are present in most filters (cartridges) in personal respiratory protective equipment. Due to this context and to enhance sustainability concepts and human health in the production of materials, this study aimed to produce activated carbon from an abundant agricultural waste in the northeast Brazil through a route that not only favors its simultaneous carbonization and activation but also its thermal neutralization. The precursor biomass was characterized by particle size analysis, a standard testing method for moisture and ash content which were characterized by FRX, CHN, and thermal analysis. The produced activated carbon was characterized by potential of hydrogen (pH), XRD, BET, SEM, TPD by ammonia and UV-Vis analysis. The activated carbons showed yields�between 73 and 78%. The morphology varied in function of the biomass interaction with the type and concentration of acid used. The produced samples showed adsorption capacity and selectivity to ammonia gas.
Development of Computer Vision Algorithms for Multi-class Waste Segregation and Their Analysis
Authors: Narayanswamy Neeraja , Rajak A. R. Abdul , Hasan Shazia
Published: April 2022

Classification of waste for recycling has been a focal point for scientists interested in the field of conservation of the environment. Recycling consists of numerous steps, of which one of the most crucial is the segregation of recyclables from all other waste. Due to a lack of safety standards in developing countries, waste collection is often done manually by domestic helpers, or "rag-pickers". Such a process risks individual and public health. The waste collection methods may ultimately cause waste to become non-recyclable due to cross-contamination. Literature shows that research in this direction focuses on a single class of waste detection. The proposed work investigates CNN, YOLO, and faster RCNN-based multi-class classification methods to detect different types of waste at the collecting point. The smart dustbin proposed employs these computer vision methods with a Raspberry Pi microcontroller and camera module. The experimental results for multi-class classification show that the CNN has 80% of accuracy with 60% of the loss. Whereas the YOLO algorithm shows an accuracy of 88% and a loss of 40%. But the best results were obtained from faster RCNN object detection with API, with an accuracy of 91% and a loss of 16%. There is already an existing method for making a smart dustbin, so the results are compared to show how computer vision can be used to make a smart dustbin. This shows how computer vision can be used to make a smart dustbin. Doi: 10.28991/ESJ-2022-06-03-015 Full Text: PDF
The Effect of Zeolite/Chitosan Hybrid Matrix for Thermal-stabilization Enhancement on the Immobilization of Aspergillus fumigatus α-Amylase
Authors: Yandri Yandri , Ropingi Hendri , Suhartati Tati , Hendri John , Irawan Bambang , Hadi Sutopo
Published: April 2022

In this paper, the A. fumigatus α-amylase had been immobilized onto zeolite/chitosan hybrid to improve its thermal-stabilization for industrial needs. The methods applied enzyme production, isolation, partial purification, immobilization, and characterization. The optimum temperatures of the native and immobilized enzymes were 50 and 55˚C, respectively. The native enzyme has KM of 3.478 ± 0.271 mg mL-1 substrate and Vmax of 2.211± 0.096 µmole mL-1 min-1, while the immobilized enzyme has KM value of 12.051 ± 4.949 mg mL-1 substrate and Vmax of 1.602 ± 0.576 µmole mL-1 min-1. The residual activity of the immobilized enzyme retained up 10.97% after fifth reuse cycles. The native enzyme has ΔGi of 104.35 ± 1.09 kJ mole-1 and t½ of 38.75 ± 1.53 min, while the immobilized enzyme has ΔGi of 108.03 ± 0.05 kJ mole-1 and t½ of 180.03 ± 3.31 min. According to the increase in half-life (t½), stability improvement of the A. fumigatusα-amylase was 4.65 times greater than the native enzyme. Thus, the zeolite/chitosan hybrid is used as a new supporting matrix for further enzyme immobilization to stabilize the enzymes. Doi: 10.28991/ESJ-2022-06-03-06 Full Text: PDF
أسلوب تمثيل الأدوار وأداء الحركات وأثره في تعليم مهارة الكلام للناطقين بغير العربيّة
Authors: ALALİ Almuttasm
Published: April 2022

يسلّط هذ البحث الضوء على جانبٍ رئيسٍ من جوانب مهارة الكلام، ألا وهو الجانب العمليّ المتمثّل بأساليب تعليم مهارة الكلام ولكي نستوعب دور ذلك الجانب العمليّ مهدنا له بالحديث المفصّل عن مفهوم الكلام وأنواعه من حيث الموضوع ، ثم تناولَ البحثُ أهمّية مهارة الكلام، وبيّن قيمتها الكبرى للإنسان بشكل عام، وتبنّى هذا البحثُ فكرة معرفة الإنسان للكلام منذ نشأة اللغة، ودعمْنا هذه الفكرة بالأدلّة، وبدأنا القسم العملي بالحديث عن الأساليب بشكلٍ عام، وتطرّقنا إلى الفرق بين الأسلوب والطريقة والاستراتيجيّة، ليقف القارئ على حدود هذه المصطلحات، ثم تناولنا في هذا البحث أسلوب تمثيل الأدوار، وأداء الحركات، والأعمال باستفاضة؛ لما له من أهميّة كُبرى في تعليم مهارة الكلام للناطقين بغير العربيّة، وتوسّعنا في هذا البحث في ذكر الإجراءات العمليّة داخل حجرة الصف، وأضفنا إليها بعض الإضافات التي تتناسب وصفات هذا الأسلوب مثل الالعاب اللغويّة، والامثال، كما أننا حاولنا في هذا البحث أن نرسم ملامح هذا الاسلوب بدقّة، حيث تمّ استخلاص مبادئ خاصّة لهذا الأسلوب، وتمّ تطبيقه في تعليم المستوى المتوسّط، بعد أن كان يُستعمَل غالبًا في تعليم المستوى المبتدئ، وحاولنا قدر الاستطاعة أن نستغل ميزات هذا الاسلوب الكثيرة من نشره لجو المرح إلى إزالته التوتّر عن الدارسين في تعليم مهارة الكلام بطريقةٍ مُثلى، و بأسهل الوسائل، وأنفعها.
Çevirmen eğitiminde edimbilimsel farkındalık
Authors: POLAT Yusuf
Published: April 2022

Eylem araştırması yönteminin kullanıldığı araştırmada 44, 29 ve 7 kişiden oluşan üç farklı örneklem topluluğundan veriler elde edilmiştir. Veriler 16 soruluk bir ankete ek olarak çeviri yapılarak veri girişi yapılan veri tabanı ve e-posta yoluyla gönderilen formlar aracılığıyla toplanmıştır. 44 öğrenciden oluşan ve tüm sınıflardan öğrencilerin yer aldığı ilk örneklem topluluğundan elde edilen veriler öğrencilerin kuramsal bilgiye nasıl yaklaştıklarını ortaya koymak üzere değerlendirilmiştir. Karşılıklı Konuşma Çevirisi dersini almış 29 ve almamış 7 öğrencinin oluşturduğu deney ve kontrol gruplarından elde edilen veriler ise çeviri uygulaması sırasında kuramsal bilgi almış olanların çeviri tercihlerinde buna bağlı olarak bir değişiklik olup olmadığını görmek üzere yorumlanmıştır. Araştırma verileri çevirmen eğitimi alan öğrencilerin, kuramsal bilgi çeviri edimi ile ilişkilendirilerek kendilerine sunulduğunda bu bilgiyi önemli bulduklarını göstermektedir. Fakat katılımcıların çeviri edimini, belli sözcüklerin ve tümcelerin yerine diğer bir dildeki sözcük ve tümcelerin konduğu bir edim olarak görmeye devam ettikleri anlaşılmaktadır. Kontrol grubundaki katılımcıların bütünüyle biçim bağımlı çeviriyi tercih etmiş olmaları, buna karşılık deney grubundaki katılımcılar arasında dolaylı çeviri tercihlerinin görece fazla olması edimbilimsel farkındalık eğitiminin öğrencileri biçim bağımlı çeviri tercihinden uzaklaştırabileceğini düşündüren bir veri olarak değerlendirilmektedir.
Intervención educativa para la prevención de complicaciones de accesos venosos periféricos
Authors: León Chumapi Carina Maribel
Published: April 2022

Introducción: La atención de enfermería en áreas de hospitalización, implica la utilización de servicios racionales, lógicos y sistemáticos; por lo tanto, estos deben de estar enmarcados en normas correctas para la prevención de complicaciones de accesos venosos periféricos, los mismos que son de vital importancia en el cuidado de la salud de las personas. Objetivo: Determinar el impacto de la intervención educativa sobre prevención de complicaciones de accesos venosos periféricos en las enfermeras del hospital Básico Yantzaza. Métodos: Estudio descriptivo, cuasi experimental de tipo antes–después, durante un periodo de seis meses, se implementó un plan de intervención educativa para la inserción y mantención de los catéteres venosos periféricos. Se efectuó un muestreo aleatorio simple. La muestra fue constituida por 46 enfermeras del Hospital Básico Yantzaza de acuerdo a la formula Sierra Bravo de 1988, el error (5%) que cometemos de estimación del tamaño de la muestra, partiendo de un nivel de confianza del 95%. Resultados: la intervención educativa para la prevención de complicaciones de accesos venosos periféricos tuvo un impacto significativo, mediante la aplicación de un pre test y post test, el personal de enfermería se encontró que la efectividad entre las mediciones efectuadas antes (Md = 1) y después (Md = 2) de implementar el programa de mejoramiento (z = -5,608b, p > 0.05 se encontró que fue efectiva.
Conocimientos de las medidas de bioseguridad en el personal de salud: revisión sistemática
Authors: Sacoto Abad Ana Cristina , Mesa-Cano Isabel Cristina , Ramírez-Coronel Andrés Alexis , Abad-Martínez Nancy Isabel
Published: April 2022

La bioseguridad es un enfoque estratégico que rige en las instituciones de salud, se sustenta en un conjunto de conocimientos y prácticas encaminadas a cambiar las actitudes en el personal para proteger la salud y evitar los riesgos a los que está expuesto en el medio laboral. Objetivo general: Examinar en la literatura científica sobre el conocimiento de bioseguridad del personal de salud. Metodología: Se realizó un estudio de revisión sistemática, con un enfoque cualitativo puesto que tiene un carácter más interpretativo, se realizó una revisión sistemática en bases de datos como PubMed, Springer, Scopus, Web of Science, Scielo, en el periodo 2015-2021 incluyendo información en los idiomas español e inglés. Resultados: La búsqueda literaria reportó un total de 875 artículos, pero tras la aplicación de criterios de selección y lectura evaluativa, se incluyó para el análisis a 18 artículos por su pertinencia y aporte al cumplimiento del objetivo. Conclusión: Los conocimientos sobre bioseguridad, se encuentra un nivel de medio a bajo o deficiente independientemente de la profesión, edad, sexo, experiencia laboral, se evidencia un mayor conocimiento sobre medidas importantes y podría decirse la más eficaz dentro de la bioseguridad, como la higiene de manos y uso de barreras de protección, pero que no alcanzan un nivel óptimo deseado.