bluuebunny/crossref_metadata_2025 huggingface dataset:
Numerical simulation of realistic top coal caving intervals under different top coal thicknesses in longwall top coal caving working face
Authors: Liu Chuang , Li Huamin
Published: June 2021

In the process of longwall top coal caving, the selection of the top coal caving interval along the advancing direction of the working face has an important effect on the top coal recovery. To explore a realistic top coal caving interval of the longwall top coal caving working face, longwall top coal caving panel 8202 in the Tongxin Coal Mine is used as an example, and 30 numerical simulation models are established by using Continuum-based Distinct Element Method simulation software to study the top coal recovery with 4.0 m, 8.0 m, 12.0 m, 16.0 m, 20.0 m and 24.0 m top coal thicknesses and 0.8 m, 1.0 m, 1.2 m, 1.6 m and 2.4 m top coal caving intervals. The results show that with an increase in the top coal caving interval, the single top coal caving amount increases. The top coal recovery is the highest with a 0.8 m top coal caving interval when the thickness of the top coal is 4.0 m, and it is the highest with a 1.2 m top coal caving interval when the coal seam thickness is greater than 4.0 m. These results provide a reference for the selection of a realistic top coal caving interval in thick coal seam caving mining.
Impact of additional mattresses in emergency CT on the automated patient centering proposed by a 3D camera: a phantom study
Authors: Greffier Joël , Frandon Julien , de Forges Hélène , Hamard Aymeric , Belaouni Asmaa , Wahl Jean Baptiste , Dabli Djamel , Beregi Jean Paul
Published: June 2021

To assess the impact of the use of additional mattresses of different thicknesses on radiation dose and image noise based on the patient centering proposed by a 3D camera for CT. An anthropomorphic phantom was placed on mattresses of different thicknesses (from 3.5 to 13.5 cm) on the table of a CT scanner. The automated patient centering proposed by a 3D camera was analysed as a function of mattress thickness and corrected for table height. For this purpose, the impact on image noise in the lung tissues in the chest area and in the soft tissues in the abdomen-pelvis area, modulated mAs (mAsmod) by the tube current modulation system (TCM) and volume CT dose index (CTDIvol) was assessed slice-by-slice along the z-axis after CT scans. With the use of a mattress, the automated centering proposed by the 3D camera resulted in placement of the phantom above the isocentre. This incorrect positioning led to a significant increase in the mAsmod along the z-axis (p < 0.05) and in the CTDIvol. Image noise was significantly higher (p < 0.05) for automated phantom centering than with manual phantom centering. Differences of image noise between acquisitions with mattresses after automatic and manual phantom centering increased with the mattress thicknesses. The use of an additional mattress placed between the patient’s back and the table-top would require correcting the vertical centering proposed by the 3D camera. This manual correction is essential to avoid increased dose delivered to the patient and higher image noise.
A method to analyze time expression profiles demonstrated in a database of chili pepper fruit development
Authors: Escoto-Sandoval Christian , Flores-Díaz Alan , Reyes-Valdés M. Humberto , Ochoa-Alejo Neftalí , Martínez Octavio
Published: June 2021

RNA-Seq experiments allow genome-wide estimation of relative gene expression. Estimation of gene expression at different time points generates time expression profiles of phenomena of interest, as for example fruit development. However, such profiles can be complex to analyze and interpret. We developed a methodology that transforms original RNA-Seq data from time course experiments into standardized expression profiles, which can be easily interpreted and analyzed. To exemplify this methodology we used RNA-Seq data obtained from 12 accessions of chili pepper (Capsicum annuumL.) during fruit development. All relevant data, as well as functions to perform analyses and interpretations from this experiment, were gathered into a publicly available R package: “Salsa”. Here we explain the rational of the methodology and exemplify the use of the package to obtain valuable insights into the multidimensional time expression changes that occur during chili pepper fruit development. We hope that this tool will be of interest for researchers studying fruit development in chili pepper as well as in other angiosperms.
Clinical efficacy and safety of different tacrolimus concentrations for the treatment of patients with idiopathic membranous nephropathy
Authors: Wang Qi , Li Manna , Cheng Xuexin , Xu Gaosi
Published: June 2021

This retrospective study aimed to explore the relative efficacy and safety of different tacrolimus (TAC) concentrations in the treatment of patients with idiopathic membranous nephropathy (IMN). A total of 260 IMN patients with nephrotic syndrome (NS) were recruited. Among these, 125 patients had TAC concentrations no greater than 5 ng/ml (CTAC ≤ 5 ng/ml), and 135 patients had TAC concentrations greater than 5 ng/ml (CTAC > 5 ng/ml). The primary outcomes included complete remission (CR) rates and overall (OR) response rates. The secondary outcomes included 24-h urinary protein (24-h UP), serum albumin and serum creatinine, and adverse events (AEs). During the 12-month follow-up, the overall response rates were significantly different between the CTAC ≤ 5 ng/ml group and the CTAC > 5 ng/ml group (P < 0.0001). However, there was no significant difference in the CR at 12 months between the two groups (chi-square, 62% vs 63%, P = 0.852). Compared with the CTAC ≤ 5 ng/ml group, the CTAC > 5 ng/ml group had improved levels of 24 h UP (P = 0.017) and serum albumin (P = 0.010). Moreover, the incidences of acute reversible nephrotoxicity (P < 0.001), hepatotoxicity (P = 0.036), new-onset diabetes mellitus (P = 0.036), and glucose intolerance (P = 0.005) were lower in the CTAC ≤ 5 ng/ml group than in the CTAC > 5 ng/ml group. The CTAC > 5 ng/ml group was improved relative to the CTAC ≤ 5 ng/ml group in terms of a PR and CR at 6 months, but there was no difference in the CR between the two groups at 12 months.
Cytotoxicity screening of Thymus vulgaris L. essential oil in brine shrimp nauplii and cancer cell lines
Authors: Niksic Haris , Becic Fahir , Koric Emina , Gusic Irma , Omeragic Elma , Muratovic Samija , Miladinovic Bojana , Duric Kemal
Published: June 2021

Among natural products, essential oils from aromatic plants have been reported to possess potent anticancer properties. In this work, we aimed to perform the cytotoxic concentration range screening and antiproliferative activity screening of chemically characterizedThymus vulgarisL. essential oil. In vivo bioassay was conducted using the brine shrimp lethality test (BSLT). In vitro evaluation of antiproliferative activity was carried out on three human tumor cell lines: breast adenocarcinoma MCF-7, lung carcinoma H460 and acute lymphoblastic leukemia MOLT-4 using MTT assay. Essential oil components thymol (36.7%), p-cymene (30.0%), γ-terpinene (9.0%) and carvacrol (3.6%) were identified by gas chromatography/mass spectrometry. Analyzed essential oil should be considered as toxic/highly toxic with LC5060.38 µg/mL in BSLT and moderate/weakly cytotoxic with IC50range 52.65–228.78 µg/mL in vitro, according to evaluated cytotoxic criteria. Essential oil induced a dose-dependent inhibition of cell proliferation in all tested tumor cell lines and showed different sensitivity. Dose dependent toxicity observed in bioassay as well as the in vitro assay confirmed that brine shrimp lethality test is an adequate method for preliminary toxicity testing ofThymus vulgarisL. essential oil in tumor cell lines.
Low-density lipoprotein receptor-related protein 1 (LRP1) is a novel receptor for apolipoprotein A4 (APOA4) in adipose tissue
Authors: Qu Jie , Fourman Sarah , Fitzgerald Maureen , Liu Min , Nair Supna , Oses-Prieto Juan , Burlingame Alma , Morris John H. , Davidson W. Sean , Tso Patrick , Bhargava Aditi
Published: June 2021

Apolipoprotein A4 (APOA4) is one of the most abundant and versatile apolipoproteins facilitating lipid transport and metabolism. APOA4 is synthesized in the small intestine, packaged onto chylomicrons, secreted into intestinal lymph and transported via circulation to several tissues, including adipose. Since its discovery nearly 4 decades ago, to date, only platelet integrin αIIbβ3 has been identified as APOA4 receptor in the plasma. Using co-immunoprecipitation coupled with mass spectrometry, we probed the APOA4 interactome in mouse gonadal fat tissue, where ApoA4 gene is not transcribed but APOA4 protein is abundant. We demonstrate that lipoprotein receptor-related protein 1 (LRP1) is the cognate receptor for APOA4 in adipose tissue. LRP1 colocalized with APOA4 in adipocytes; it interacted with APOA4 under fasting condition and their interaction was enhanced during lipid feeding concomitant with increased APOA4 levels in plasma. In 3T3-L1 mature adipocytes, APOA4 promoted glucose uptake both in absence and presence of insulin in a dose-dependent manner. Knockdown of LRP1 abrogated APOA4-induced glucose uptake as well as activation of phosphatidylinositol 3 kinase (PI3K)-mediated protein kinase B (AKT). Taken together, we identified LRP1 as a novel receptor for APOA4 in promoting glucose uptake. Considering both APOA4 and LRP1 are multifunctional players in lipid and glucose metabolism, our finding opens up a door to better understand the molecular mechanisms along APOA4-LRP1 axis, whose dysregulation leads to obesity, cardiovascular disease, and diabetes.
A mouse model of prenatal exposure to Interleukin-6 to study the developmental origin of health and disease
Authors: Srivastava Tarak , Joshi Trupti , Heruth Daniel P. , Rezaiekhaligh Mohammad H. , Garola Robert E. , Zhou Jianping , Boinpelly Varun C. , Ali Mohammed Farhan , Alon Uri S. , Sharma Madhulika , Vanden Heuvel Gregory B. , Mahajan Pramod , Priya Lakshmi , Jiang Yuexu , McCarthy Ellen T. , Savin Virginia J. , Sharma Ram , Sharma Mukut
Published: June 2021

Systemic inflammation in pregnant obese women is associated with 1.5- to 2-fold increase in serum Interleukin-6 (IL-6) and newborns with lower kidney/body weight ratio but the role of IL-6 in increased susceptibility to chronic kidney (CKD) in adult progeny is not known. Since IL-6 crosses the placental barrier, we administered recombinant IL-6 (10 pg/g) to pregnant mice starting at mid-gestation yielded newborns with lower body (p < 0.001) and kidney (p < 0.001) weights. Histomorphometry indicated decreased nephrogenic zone width (p = 0.039) with increased numbers of mature glomeruli (p = 0.002) and pre-tubular aggregates (p = 0.041). Accelerated maturation in IL-6 newborns was suggested by early expression of podocyte-specific protein podocin in glomeruli, increased 5-methyl-cytosine (LC–MS analysis for CpG DNA methylation) and altered expression of certain genes of cell-cycle and apoptosis (RT-qPCR array-analysis). Western blotting showed upregulated pJAK2/pSTAT3. Thus, treating dams with IL-6 as a surrogate provides newborns to study effects of maternal systemic inflammation on future susceptibility to CKD in adulthood.
Criteria-based curation of a therapy-focused compendium to support treatment recommendations in precision oncology
Authors: Lin Frank P. , Thavaneswaran Subotheni , Grady John P. , Ballinger Mandy , Kansara Maya , Oakes Samantha R. , Desai Jayesh , Lee Chee Khoon , Simes John , Thomas David M.
Published: June 2021

While several resources exist that interpret therapeutic significance of genomic alterations in cancer, many regional real-world issues limit access to drugs. There is a need for a pragmatic, evidence-based, context-adapted tool to guide clinical management based on molecular biomarkers. To this end, we have structured a compendium of approved and experimental therapies with associated biomarkers following a survey of drug regulatory databases, existing knowledge bases, and published literature. Each biomarker-disease-therapy triplet was categorised using a tiering system reflective of key therapeutic considerations: approved and reimbursed therapies with respect to a jurisdiction (Tier 1), evidence of efficacy or approval in another jurisdiction (Tier 2), evidence of antitumour activity (Tier 3), and plausible biological rationale (Tier 4). Two resistance categories were defined: lack of efficacy (Tier R1) or antitumor activity (Tier R2). Based on this framework, we curated a digital resource focused on drugs relevant in the Australian healthcare system (TOPOGRAPH: Therapy Oriented Precision Oncology Guidelines for Recommending Anticancer Pharmaceuticals). As of November 2020, TOPOGRAPH comprised 2810 biomarker-disease-therapy triplets in 989 expert-appraised entries, including 373 therapies, 199 biomarkers, and 106 cancer types. In the 345 therapies catalogued, 84 (24%) and 65 (19%) were designated Tiers 1 and 2, respectively, while 271 (79%) therapies were supported by preclinical studies, early clinical trials, retrospective studies, or case series (Tiers 3 and 4). A companion algorithm was also developed to support rational, context-appropriate treatment selection informed by molecular biomarkers. This framework can be readily adapted to build similar resources in other jurisdictions to support therapeutic decision-making.
TGF-β-dependent reprogramming of amino acid metabolism induces epithelial–mesenchymal transition in non-small cell lung cancers
Authors: Nakasuka Fumie , Tabata Sho , Sakamoto Takeharu , Hirayama Akiyoshi , Ebi Hiromichi , Yamada Tadaaki , Umetsu Ko , Ohishi Maki , Ueno Ayano , Goto Hisatsugu , Sugimoto Masahiro , Nishioka Yasuhiko , Yamada Yasuhiro , Tomita Masaru , Sasaki Atsuo T. , Yano Seiji , Soga Tomoyoshi
Published: June 2021

Epithelial–mesenchymal transition (EMT)—a fundamental process in embryogenesis and wound healing—promotes tumor metastasis and resistance to chemotherapy. While studies have identified signaling components and transcriptional factors responsible in the TGF-β-dependent EMT, whether and how intracellular metabolism is integrated with EMT remains to be fully elucidated. Here, we showed that TGF-β induces reprogramming of intracellular amino acid metabolism, which is necessary to promote EMT in non-small cell lung cancer cells. Combined metabolome and transcriptome analysis identified prolyl 4-hydroxylase α3 (P4HA3), an enzyme implicated in cancer metabolism, to be upregulated during TGF-β stimulation. Further, knockdown of P4HA3 diminished TGF-β-dependent changes in amino acids, EMT, and tumor metastasis. Conversely, manipulation of extracellular amino acids induced EMT-like responses without TGF-β stimulation. These results suggest a previously unappreciated requirement for the reprogramming of amino acid metabolism via P4HA3 for TGF-β-dependent EMT and implicate a P4HA3 inhibitor as a potential therapeutic agent for cancer.
Quenched topological boundary modes can persist in a trivial system
Authors: Lee Ching Hua , Song Justin C. W.
Published: June 2021

Topological boundary modes can occur at the spatial interface between a topological and gapped trivial phase and exhibit a wavefunction that exponentially decays in the gap. Here we argue that this intuition fails for a temporal boundary between a prequench topological phase that possess topological boundary eigenstates and a postquench gapped trivial phase that does not possess any eigenstates in its gap. In particular, we find that characteristics of states (e.g., probability density) prepared in a topologically non-trivial system can persist long after it is quenched into a gapped trivial phase with spatial profiles that appear frozen over long times postquench. After this near-stationary window, topological boundary mode profiles decay albeit, slowly in a power-law fashion. This behavior highlights the unusual features of nonequilibrium protocols enabling quenches to extend and control localized states of both topological and non-topological origins.
Polypyridyl iron(iii) complexes containing long alkyl chains: synthesis, characterization, DFT calculations and biological activity
Authors: Melotti Marcelo , S. S. Paqui Matheus , Amorim André L. , P. de Paula Carla , Rocha Marina C. , Malavazi Iran , Cunha Anderson , S. Santana Francielli , Ribeiro Ronny R. , Gariani Rogério A. , Mendes Samuel R. , Xavier Fernando R.
Published: June 2021

A bis(picolyl)amine ligand was functionalized with a long alkyl chain, and two iron(iii) complexes were prepared and their biological activity was presented.
Yb(iii)-catalysed syn-thioallylation of ynamides
Authors: Gogoi Manash Protim , Vanjari Rajeshwer , Prabagar B. , Yang Shengwen , Dutta Shubham , Mallick Rajendra K. , Gandon Vincent , Sahoo Akhila K.
Published: June 2021

Reported herein is a syn-thioallylation of ynamides incorporating a sulfide moiety at the α-position and an allyl group at the β-position of the ynamide.
Anion binding properties of a hollow PdL-cage
Authors: Timmer Brian J. J. , Mooibroek Tiddo J.
Published: June 2021

A hollow ‘PdL’ cage disintegrates in the presence of coordinating anions, but binds to the non-coordinating anions BF4−, ClO4− and NO3− with selectivity towards nitrate.
Three Zn(ii) coordination polymers constructed with a new amide-thiophene-derived bis-pyridyl ligand as ultrasensitive luminescent sensors for Hg(ii) and purines
Authors: Wang Xiuli , Ma Jianxin , Xu Na , Wang Yue , Sun Jiayu , Liu Guocheng
Published: June 2021

A new amide-thiophene-derived ligand (4-bpft) was designed and used to construct three LCPs 1–3, which could detect Hg(ii), adenine, and guanine.
The dependence of the spectroscopic properties of orcein dyes on solvent proticity: insights from theory and experiments
Authors: Clementi Catia , Romani Aldo , Elisei Fausto , De Angelis Filippo , Daus Federica , Nunzi Francesca
Published: June 2021

The electronic spectral properties of α-hydroxy orcein (α-HO), one of the main components of orcein dye, have been extensively investigated in solvents of different proticity through UV-Vis spectrophotometry combined with DFT and TDDFT calculations.
Impact of the particle mixing state on the hygroscopicity of internally mixed sodium chloride–ammonium sulfate single droplets: a theoretical and experimental study
Authors: Tobon Yeny A. , El Hajj Danielle , Seng Samantha , Bengrad Ferdaous , Moreau Myriam , Visez Nicolas , Chiapello Isabelle , Crumeyrolle Suzanne , Choël Marie
Published: June 2021

Humidograms of mixed NaCl/(NH4)2SO4 particles show two or three transitions depending on the initial molar composition. Up to five solid salts can coexist within the dry particles: NaCl, (NH4)2SO4, NH4Cl, Na2SO4 and NH4NaSO4·2H2O.
Emerging photothermal-derived multimodal synergistic therapy in combating bacterial infections
Authors: Huo Jingjing , Jia Qingyan , Huang Han , Zhang Jing , Li Peng , Dong Xiaochen , Huang Wei
Published: June 2021

Photothermal therapy (PTT)-derived multimodal synergistic treatments exhibit a super-additive effect in fighting bacterial infections.
Structure, reactivity, and spectroscopy of nitrogenase-related synthetic and biological clusters
Authors: Wang Chen-Hao , DeBeer Serena
Published: June 2021

In this review, recent studies on nitrogenase-related synthetic molecular complexes and biological clusters are discussed, with a focus on their reactivity and spectroscopic characterization.
Getting rid of the shackles from the support: construction of recoverable semi-homogeneous catalysts with attapulgite
Authors: Guo Ruixiang , Wang Gang , Liu Wei , Yao Zibei , Liu Weisheng
Published: June 2021

Using a strategy of “adsorption–desorption–adsorption” to immobilize homogeneous catalysts, these active species, which can be dispersed at the molecular scale, could catalyze the reaction herein like a homogeneous catalyst.
Maternal galactooligosaccharides supplementation programmed immune defense, microbial colonization and intestinal development in piglets
Authors: Wu Yujun , Zhang Xiangyu , Pi Yu , Han Dandan , Feng Cuiping , Zhao Junying , Chen Lijun , Che Dongsheng , Bao Hongxing , Xie Zhengjun , Wang Junjun
Published: June 2021

Dietary GOS in sows nutritionally programmed intestinal Alloprevotella and plasma IgA in their offspring, contributing to a better intestinal barrier and growth performance of piglets.
Artichoke leaf extract supplementation lowers hepatic oxidative stress and inflammation and increases multidrug resistance-associated protein 2 in mice fed a high-fat and high-cholesterol diet
Authors: Liao Guo-Chen , Jhuang Jia-Hua , Yao Hsien-Tsung
Published: June 2021

Artichoke (Cynara scolymus) leaf extract (ALE) contains many phytonutrients that may have antioxidant and anti-inflammation activities against many diseases including liver damage.
Furoic acid and derivatives as atypical dienes in Diels–Alder reactions
Authors: Cioc Răzvan C. , Smak Tom J. , Crockatt Marc , van der Waal Jan C. , Bruijnincx Pieter C. A.
Published: June 2021

Bio-derived furoic acids and their derivatives are unexpectedly reactive dienes in aqueous Diels–Alder cycloadditions with maleimides.
Towards the environmentally friendly solution processing of metal halide perovskite technology
Authors: Hoang Minh Tam , Ünlü Feray , Martens Wayde , Bell John , Mathur Sanjay , Wang Hongxia
Published: June 2021

This article provides an overview of the research on green solvent alternatives for perovskite technology, with a fundamental discussion and analysis of the relationship between solvents, molecular ligands, and perovskite material properties.
Supported ionic liquid-like phases as efficient solid ionic solvents for the immobilisation of alcohol dehydrogenases towards the development of stereoselective bioreductions
Authors: Porcar Raul , Lavandera Iván , Lozano Pedro , Altava Belen , Luis Santiago V. , Gotor-Fernández Vicente , García-Verdugo Eduardo
Published: June 2021

Supported ionic liquids have been evaluated for the immobilisation of the alcohol dehydrogenase from Rhodococcus ruber (ADH-A). The resulting biocatalytic systems remain active after consecutive uses, prolonged storage and under flow conditions.
Facile fabrication of graphene-based high-performance microsupercapacitors operating at a high temperature of 150 °C
Authors: Mishukova Viktoriia , Boulanger Nicolas , Iakunkov Artem , Sollami Delekta Szymon , Zhuang Xiaodong , Talyzin Alexandr , Li Jiantong
Published: June 2021

A facile process enabled the fabrication of high-performance graphene-based micro-supercapacitors that can operate at temperatures up to 150 °C.
Evidence of oxygen bubbles forming nanotube embryos in porous anodic oxides
Authors: Gong Tianle , Li Chengyuan , Li Xin , Yue Hangyu , Zhu Xufei , Zhao Ziyu , Lv Renquan , Zhu Junwu
Published: June 2021

Anodic TiO2 nanotubes have been studied widely for two decades because of their regular tubular structures and extensive applications.
Protein aggregation detection with fluorescent macromolecular and nanostructured probes: challenges and opportunities
Authors: Cingolani Matteo , Mummolo Liviana , Lugli Francesca , Zaffagnini Mirko , Genovese Damiano
Published: June 2021

Nanoprobes based on various nanomaterials, polymers or AIEgens are overcoming previous limitations for diagnosis and therapy of early-stage protein aggregation.
Na2La2B10O19: a new lanthanum sodium borate with infinite 2D layer 2∞[B10O19]8− and moderate birefringence
Authors: Wu Chengfa , Feng Junwei , Yu Feng
Published: June 2021

A new La-based borate Na2La2B10O19 with infinite 2D double layers composed of (B5O12)9− FBBs and a moderate birefringence of 0.06 at 1064 nm.
Theoretical investigation of the nature of π(BB)⋯M interactions in coinage metal π-diborene complexes
Authors: Li Zhendong , Liu Yulin , Li Xiaomeng , Li Qingzhong , Li Xiaoyan
Published: June 2021

π(BB)⋯M interactions are strong covalent bonds and their strengths increase in the sequence of M = Ag, Cu, and Au, for the same number of MCl. Theoretical investigation on the nature of π(BB)⋯M interactions in coinage metal π-diborene complexes is outlined here.
Aryl carbazole-based macrocycles: synthesis, their remarkably stable radical cations and host–guest complexation with fullerenes
Authors: Mao Lijun , Zhou Manfei , Niu Yan-Fei , Zhao Xiao-Li , Shi Xueliang
Published: June 2021

Herein, we have designed and synthesized a series of aryl carbazole-based macrocycles and their stable radical cation species and interesting fullerene recognition were systematically investigated.
Visible-light-induced remote C(sp3)–H sulfonylvinylation: assembly of cyanoalkylated vinyl sulfones
Authors: Bao Ping , Yu Feiyan , He Fu-Sheng , Tang Zhimei , Deng Wei-Ping , Wu Jie
Published: June 2021

A photoinduced three-component sulfonylvinylation reaction of propargyl alcohols, potassium metabisulfite and cycloketone oxime esters is developed, affording cyanoalkylated vinyl sulfones in moderate to good yields.
Discrimination between sialic acid linkage modes using sialyllactose-imprinted polymers
Authors: Mavliutova Liliia , Munoz Aldeguer Bruna , Wiklander Jesper , Wierzbicka Celina , Huynh Chau Minh , Nicholls Ian A. , Irgum Knut , Sellergren Börje
Published: June 2021

2,6′- and 2,3′-sialyllactose imprinted polymers (MIPs) capable of discriminating between two modes of sialic acid linkages in glycans are reported.
Correction: Dendritic fibrous nanosilica-supported dendritic IL/Ru(ii) as photocatalysts for the dicarbofunctionalization of styrenes with carbon dioxide and amines
Authors: Liu Can , Rouhi Jalal
Published: June 2021

Correction for ‘Dendritic fibrous nanosilica-supported dendritic IL/Ru(ii) as photocatalysts for the dicarbofunctionalization of styrenes with carbon dioxide and amines’ by Can Liu et al., RSC Adv., 2021, 11, 9933–9941, DOI: 10.1039/D0RA10729H.
Precision photothermal therapy and photoacoustic imaging by in situ activatable thermoplasmonics
Authors: Liu Yahua , Mo Fengye , Hu Jialing , Jiang Qunying , Wang Xiuyuan , Zou Zhiqiao , Zhang Xian-Zheng , Pang Dai-Wen , Liu Xiaoqing
Published: June 2021

A tumor microenvironment-activated photoagent is reported for precise photothermal therapy and photoacoustic imaging via controllable thermoplasmonics. The agent can sensitively image tumors and lymph node metastasis and specifically ablate tumors.
Construction of a hydroxide responsive C3-symmetric supramolecular gel for controlled release of small molecules
Authors: Liu Yucun , Tan Yuanyuan , Liu Zhixue , Che Guangbo
Published: June 2021

The prepared C3-symmetric supramolecular gel can respond to OH− and has a great potential as a biomaterial for controlled release of small molecules.
Peculiarly fast Li-ion conduction mechanism in a succinonitrile-based molecular crystal electrolyte: a molecular dynamics study
Authors: Sasaki Ryoma , Moriya Makoto , Watanabe Yuki , Nishio Kazunori , Hitosugi Taro , Tateyama Yoshitaka
Published: June 2021

Li-ions constructing a crystalline framework behave as fast transport carriers as well owing to the surrounding flexible moieties in a succinonitrile-based molecular crystal electrolyte.
Functionalized gold-nanoparticles enhance photosystem II driven photocurrent in a hybrid nano-bio-photoelectrochemical cell
Authors: Shoyhet Hagit , Pavlopoulos Nicholas G. , Amirav Lilac , Adir Noam
Published: June 2021

Photosystem II is attached to DCBQ modified Au-nanoparticles and used in hybrid bio-photoelectrochemical cells for efficient conversion of solar energy to electrical current. The modified AuNPs enhance both PSII activity and electrical connectivity.
High-capacity zinc–iodine flow batteries enabled by a polymer–polyiodide complex cathode
Authors: Yang Jing , Song Yuxi , Liu Qinghua , Tang Ao
Published: June 2021

The capacity of iodide is effectively unlocked by using a polymer–polyiodide complex, which delivers both greatly enhanced discharge capacity and superior long-term cycling stability for zinc–iodine flow batteries.
Green-synthesized CeO2nanoparticles for photocatalytic, antimicrobial, antioxidant and cytotoxicity activities
Authors: Naidi Siti Najihah , Harunsani Mohammad Hilni , Tan Ai Ling , Khan Mohammad Mansoob
Published: June 2021

Synthesis of CeO2NPs using different plant/food-based products, and their various applications.
Substance P containing peptide gene delivery vectors for specifically transfecting glioma cells mediated by a neurokinin-1 receptor
Authors: Ding Guihua , Wang Taoran , Han Zhenbin , Tian Long , Cheng Qin , Luo Longlong , Zhao Baoquan , Wang Chenhong , Feng Siliang , Wang Lianshuai , Meng Zhao , Meng Qingbin
Published: June 2021

Gene therapy provides a promising treatment for glioblastoma multiforme, which mainly depends on two key aspects, crossing the blood brain barrier (BBB) effectively and transfecting target cells selectively.
Nanoscale molecular layers for memory devices: challenges and opportunities for commercialization
Authors: Gupta Ritu , Jash Priyajit , Mondal Prakash Chandra
Published: June 2021

The present review describes recent developments in nanoscale molecular films, and discusses why devices comprising redox-active organic, organometallic, complexes, and biomolecules might hold the potential for next-generation electronic applications.
Building responsive materials by assembling {Fe4Co4} switchable molecular cubes
Authors: Xuan Qui Pham , Glatz Jana , Benchohra Amina , Jiménez Juan-Ramón , Plamont Rémi , Chamoreau Lise-Marie , Flambard Alexandrine , Li Yanling , Lisnard Laurent , Dambournet Damien , Borkiewicz Olaf J. , Boillot Marie-Laure , Catala Laure , Tissot Antoine , Lescouëzec Rodrigue
Published: June 2021

Molecular {Fe4Co4} cubic switches can be assembled to form a responsive polymeric material, whose magnetic state allows sensing the intercalation/deintercalation of small solvent molecules.
Control of the Cu2O crystal orientation and the application of a ZnO/Cu2O self-powered photodetector in visible-light-encrypted communication
Authors: Bu Yichen , Xu Jianping , Shi Shaobo , Chen Jing , Li Menghan , Zhang Qiuyang , Yang Pengcheng , Xu Jianghua , Zhang Xiaosong , Kong Lina , Li Lan
Published: June 2021

Using ZnO/Cu2O UV-Vis dual-band photoresponse to correctly decode encrypted visible light signals.
A highly efficient purely organic room-temperature phosphorescence film based on a selenium-containing emitter for sensitive oxygen detection
Authors: Wang Shuai , Shu Haiyang , Han Xianchao , Wu Xiaofu , Tong Hui , Wang Lixiang
Published: June 2021

A purely organic room-temperature phosphorescence emitter based on 9H-selenoxanthen-9-one achieves a high phosphorescence quantum yield of 44.3% in doped films, and highly reversible and sensitive oxygen-sensing performance.
Profiles of Linguistic Multicompetence in Vietnamese–English Speakers
Authors: Wang Cen , Verdon Sarah , McLeod Sharynne , Tran Van H.
Published: June 2021

Purpose

Speech-language pathologists work with increasing numbers of multilingual speakers; however, even when the same languages are spoken, multilingual speakers are not homogeneous. Linguistic multicompetence (aka multi-competence) considers competency across all languages and is associated with multiple demographic, migration, linguistic, and cultural factors.

Method

This article examines the linguistic multicompetence of adults with Vietnamese heritage living in Australia (
n
= 271) and factors associated with varying profiles of multilingualism. Participants completed a self-report questionnaire (available in English and Vietnamese) regarding their language proficiency and associated factors.

Results

Participants were largely (76.6%) first-generation migrants to Australia. Three distinct profiles of linguistic multicompetence were statistically identified using a cluster analysis: (a) Vietnamese proficient (
n
= 81, 31%), (b) similar proficiency (
n
= 135, 52%), and (c) English proficient (
n
= 43, 17%); that is, half were proficient in both languages. Multinomial logistic regression analyses compared participants profiled as having similar proficiency with those who were more dominant in one language. Factors associated with the Vietnamese proficient group (compared with the similar proficiency group) were that the participants used Vietnamese much more than English with different people across different situations, were more likely to believe that maintaining Vietnamese helped them communicate in English, and earned less. Participants in the English proficient group used English more than Vietnamese with different people across different situations, were more likely to have lived in English-speaking countries longer, were younger in age, and were less likely to believe that maintaining Vietnamese helped improve academic study than those with similar proficiency.

Conclusion

Undertaking a comprehensive language profile is an important component of any multilingual assessment to enable speech-language pathologists to develop an understanding of different presentations of linguistic multicompetence, engage in culturally responsive practice, and acknowledge that high levels of competence can be achieved across multiple languages.

Supplemental Material

https://doi.org/10.23641/asha.14781984
The Impact of COVID-19 on Speech-Language Pathologists Engaged in Clinical Practices With Elevated Coronavirus Transmission Risk
Authors: Kearney Ann , Searl Jeff , Erickson-DiRenzo Elizabeth , Doyle Philip C.
Published: June 2021

Purpose

This study assessed and described potential clinical practice changes secondary to COVID-19 that emerged as an early response to the pandemic for speech-language pathologists (SLPs) engaged in voice, alaryngeal, and swallowing activities that may increase the risk of virus transmission.

Method

SLPs from the United States and Canada (
n
= 665) who were engaged in clinical activities that might elevate the risk of COVID-19 exposure completed an online survey regarding their clinical practices. Topics assessed included potential clinical service modifications, COVID-19 testing and health, and potential financial impacts in the early time period of the pandemic.

Results

The percentage of SLPs completing the most endoscopic procedures prepandemic (≥ 10/week) was reduced from 39% of respondents to 3% due to the pandemic. Those who completed the most tracheoesophageal puncture voice prosthesis changes (≥ 5/week) reported a reduction in frequency from 24% to 6%. Twenty-five percent of SLPs reported that they were tested for COVID-19, and 6% reported a positive result. Descriptive statistics suggest that COVID-19 testing rates of SLPs, the percentage of SLPs experiencing a financial impact, and the percentage who were furloughed varied across SLP work setting.

Conclusions

These findings provide the first data characterizing the impact on COVID-19 on clinical practice for SLPs engaged in procedures such as endoscopy and laryngectomy care. The results indicate that, as frontline workers, SLPs were directly impacted in their practice patterns, personal health, safety, and financial security, and that these reported impacts occurred differently across SLP work settings.
A novel single‐phase grounding fault voltage full compensation topology based on antiphase transformer
Authors: Cai Xiaobin , Liu Hongwen , Huang Xiaohui , Huang Chunhui , Chai Chenchao , Rong Fei
Published: June 2021

Multi‐tap and multi‐capacitors type arc suppression coils are commonly used in distribution systems. Due to their low compensation accuracy and limited arc suppression capability, it is hardly to avoid personal safety accidents and wildfires absolutely. In this paper, a novel single‐phase grounding fault voltage full compensation topology based on antiphase transformer is proposed, which is composed by an antiphase transformer, a phase‐selection switch and a multi‐tap single‐phase voltage regulator. The proposed topology can control the neutral point voltage, thus cause the fault voltage being zero. By this way, the lack of arc suppression coil is overcome. The novel compensation topology features low costs, high precision of fault voltage compensation. The principle of the novel compensation topology is explained. The mathematical expressions of residual voltage and current are derived in detail. Finally, the simulation model and experimental platform were built. The results show that the proposed novel compensation topology can effectively make up for the shortcomings of traditional arc suppression coils when it is used with them.
Automatic generation of optimal road trajectory for the rescue vehicle in case of emergency on mountain freeway using reinforcement learning approach
Authors: Yang Jingwen , Wang Ping , Yuan Wubei , Ju Yongfeng , Han Wanli , Zhao Jianyou
Published: June 2021

Rapid rescue response has the highest priority in case of emergency randomly happening on the freeway network, which allows rescue vehicles to have many trajectory options. Searching for the fastest way is not easy within a short time after traffic accident happens especially for the mountainous area with special characteristics such as limited traffic capacity, enclosed internal space and so on. Here, road segment model is proposed to determine smallest road segment covering possible rescue ways. Other than traditional optimal search methods, modified reinforcement‐leaning is introduced to find the optimal road trajectory. The proposed methods are tested in the freeway of Qinling Tunnel group, Xihan Freeway of Shaanxi province, China as a case study. Compared with traditional shortest path method, the rescue vehicle arrival time to the accident location is shortened from 22.9 to 6.5 min and dissipation time is also shortened from 52.4 to 25.6 min. Both of them show the proposed road trajectory could improve the rescue effectiveness and reduce the influence to road network. Successful application of these case study shows they could probably extend to use to other scenarios and contribute to improve the intelligence transportation system.
Study on mechanical response and crack development law of tunnel
Authors: Tan Dezhu
Published: June 2021

Considering the linear elastic fracture mechanics and complex function theory, considering the non hydrostatic pressure field, the stress solutions of lining and surrounding rock of deep buried circular underground cavern with lining under the action of external internal pressure are studied. The fracture mechanics model of underground cavern supporting structure is established, and the numerical verification is carried out. The analytical solution of circular pressure cavern with lining shows that when the internal pressure is 0, it can degenerate into the existing classical solution. The results of finite element calculation and analytical calculation show that the tensile stress of lining is very large at the vault and arch bottom under the action of strong external supporting force. The calculation shows that the cracks of lining will expand and open under the action of tensile stress, and the lining is in the shape of “flat duck egg”, However, if there is no through rupture, there will be great stress concentration at the top and bottom of the arch, and the tensile stress value is much larger than that calculated by elastic mechanics. Therefore, it is a good method to configure a certain amount of reinforcement to enhance the stiffness and tensile strength of the lining.
Dynamic Response Analysis of Spur Gear System with Backlash
Authors: Li Chao , Wang Jigang
Published: June 2021

There are few studies on space-driven gear systems in the existing literature. In this paper, a spacedriven two-stage spur gear system is taken as the research object, and a 10 DOF dynamic model is established. A nonlinear dynamic response analysis was performed. The backlash was introduced into the dynamic model, and the time-varying stiffness was corrected to make the theoretical model closer to reality. By comparing two kinds of dynamic response curves with and without return difference, it was illustrated that the influence of return difference on dynamic transmission error in a gear system. The results obtained in this paper provide a reference and basis for subsequent research.
Analysis on the potential of ecological water replenishment for Baiyangdian Lake by reservoirs in the mountainous area of Daqing River
Authors: Dai Yanyu , Wang Siqi , Zhu Hongpeng , Xu Yiran
Published: June 2021

Reservoirs in the Daqing River mountainous area have always been an important source of replenishment for Baiyangdian Lake. With the development of water source economy and society, the reservoir’s ecological water replenishment potential for Baiyangdian Lake will undergo great changes. This article first analyzes the current situation of ecological water replenishment in Baiyangdian Lake. On this basis, the ecological water supply potential of the upstream reservoir to Baiyangdian Lake in the future was calculated. The results of the study show that from 2001 to 2018, the amount of water entering the upper reaches of the reservoir showed an overall upward trend, and the upward trend of runoff from the Xidayang Reservoir was the most obvious. Under different incoming water conditions, the ecological water supply potential of the upstream reservoir to Baiyangdian varies greatly. It can reach 320 million m3 in a wet year and only 50 million m3 in a dry year. In the continuous dry years, the average multi-year water supply potential of the reservoirs to the river and Baiyangdian Lake is about 146 million m3. The results of this paper can be used as a reference for Baiyangdian Lake’s ecological water replenishment scheduling
Axial Vibration Analysis of Thrust Support of Vertical Hydrogenerator Unit
Authors: Long Yuanlin , Ye Yuping
Published: June 2021

Axial vibration is the main accident that affects the normal function of the vertical hydro-generator unit and endangers the use of the unit. There are many reasons for the axial vibration of the unit. This article only analyzes the mechanism of the axial vibration of the thrust bracket of the vertical unit caused by the connection of the thrust head and the mirror plate, and gives a real machine measurement example and treatment measures.
Response analysis of long-period seismic action in far field to long-span continuous beam bridge with isolated high piers
Authors: Yanan Wang , Guangwu Tang , Haiming Liu , Fujie Wang , yuan Chen
Published: June 2021

In order to study the influence of far-field long-period seismic waves on high-pier and long-span continuous beam bridge, taking a high-pier and long-span continuous beam bridge with span arrangement of (95+170+95) m as an example, a numerical analysis model is established based on finite element software. According to the established wave selection criterion, 10 far-field long-period seismic records and 10 ordinary seismic records are selected from the strong earthquake record database. Using nonlinear time history analysis method, the difference of seismic response of long-span continuous beam bridge with isolated high piers under the action of ordinary ground motion and far-field long-period ground motion is studied. The results show that compared with the ordinary ground motion, the seismic response of long-span continuous beam bridge with isolated high piers is obviously increased under the action of long-period ground motion in the far field. When building isolated long-span bridges in areas with great influence of long-period ground motion in the far field, attention should be paid to the adverse effects caused by the frequency spectrum characteristics of ground motion.
Implementation of the strategy of sustainable development in the model of critical theory of society and education system
Authors: Chervona Lesya , Chornoivan Hanna , Grynko Olena , Myroshnychenko Serhii
Published: June 2021

The call for democratic reconstruction of education should contribute to the development of the acquisition and use of knowledge and thought of as a response to emerging technologies and trends in globalization. In particular, be aware that nowadays some unfair terms communities, individuals are privileged in having access to technology, a high-tech skills and cultural capital than the less privileged communities. One way to overcome this abyss of a whole complex of new classes of inequalities, gender, race, education is restructuring so that all students have access to new technologies and new knowledge in the system democratized education and training process. Hegelian dialectics can help the efficiency of the relationship between students and teachers today in a situation where there is a lack of cultural, social experience as well as the specific subjectivity between groups, nations and generations. Teachers, students, and citizens must recognize this potential conflict and consolidate work to overcome these conflicts, making these actions more productive. Overall, the democratization of education can be enhanced in part by increasing elaboration and interactive forms of education, including such as distance education, the development of collective educational websites, online discussions and a scientific online community, shared internet research projects. But the restructuring of education also requires targeted public, values education, literacy cultivation. For teaching and learning books and printed materials based on multimedia and Internet materials should be considered as an additional, rather than as the primary means of democratization of education.
Introducing the concepts and methods of humanism into education for ensuring quality sustainable development
Authors: Popovych Mykola , Levkulych Vasyl , Khodanych Yuriy , Popovych Tereziia
Published: June 2021

Humanism as a principle for sustainable development of society, a model for the management of education and public education, is recognized as a fundamental principle by proponents of various schools of thought, social science, management and philosophy, and pedagogy. In their view, the philosophy of education and upbringing should clearly delineate the range of humanistic and moral values, define the social institutions designed to form an orientation towards these values, justify the relationship between the individual and the social qualities of the individual that could contribute to the “spirit of democracy” in society. However, addressing these important issues requires an exploration of morality identifying its nature, its functions in cognizing the world, and how it differs from other forms of cognition. According to the proponents of this socially-oriented direction of the management and educational philosophy, an important aim of education and upbringing is to develop the individual’s ability to reflect on moral topics; and this, they argue, is achieved mainly through the “language of morality” logic.