bluuebunny/crossref_metadata_2025 huggingface dataset:
Aproximações entre as intervenções gráficas urbanas e o design
Authors: Lassala Gustavo
Published: January 2025

O objetivo do estudo é mapear, comparar e analisar como as intervenções gráficas urbanas convergem por meio de recursos comuns ao design em um contexto de deslocalização cultural para ampliar os pontos de contato e interação com o público. Parte-se do princípio de que existe um potencial de significação nas manifestações dos interventores urbanos por meio de recursos comuns ao design. O assunto apresenta relações com a linguagem gráfica das mídias digitais e o papel social do design contemporâneo. Pretende-se com isso, contribuir para a ampliação dos conceitos no campo do design e com os estudos das práticas e métodos não-acadêmicos. A compreensão de tal objeto servirá para refletir sobre a prática do design em um contexto mais amplo que extrapola o limite da prática projetual convencional, pois trata de indivíduos que, na maioria das vezes, estão à margem da organização social mediada pelas instituições dominantes.
Anatomical and topographic features of the hip flexor muscles in a large white pig
Authors: Slesarenko N. A. , Oganov E. O. , Shirokova E. O.
Published: January 2025

One of the most important tasks of the agro-industrial complex of the Russian Federation at this stage is to solve the problems associated with increasing meat resources, providing the population with high-quality meat products. The development of domestic beef cattle breeding will create conditions for the sustainable development of rural areas, which is one of the most important strategic goals of state policy, the achievement of which will ensure food security, increase the competitiveness of the Russian economy and the well-being of citizens. The article presents the anatomical features of hip flexors (flexors) in a large white breed pig. It has been shown that the main flexor of the hip joint in a pig is the iliolumbar muscle. It is quite fleshy, large, whereas the small lumbar muscle is less developed and is covered by the large lumbar muscle. Among the heads of the iliac muscle, the lateral head is well differentiated on the ventral surface of the iliac bone body, whereas the medial one is represented as a thin, small muscle located between the tendon ends of the large and small lumbar muscles. The material for the research was a sectional material – pelvic limbs (n=10), selected from pigs of a large white breed, without external signs of pathologies of the musculoskeletal system. Methods of fine macro- and microanatomic dissection, biomechanical modeling with subsequent functional analysis of the studied structures were used. New data on the anatomical and topical features of hip flexors in a large white pig are presented, which are determined by the mechanism of the static locomotor act of the animal. The points of fixation of the long and short tendons of the tailor's muscle have been established, which, covering and covering the distal part of the ilio-lumbar muscle from the ventral surface, optionally perform the function of a supporting ligament for this muscle.
The influence of the age of boars on their breeding qualities
Authors: Samsonova O. E.
Published: January 2025

The reproductive performance of sows depends partly on the fertility of the boar. Many factors influence the fertility of the boar: external (environment) and internal (genetics). Acceleration of growth of young pigs occurs, as a rule, due to genetic improvements. The article presents the results of studies of sexual development and fertilizing ability of boars of three imported breeds (Landrace, Yorkshire and Duroc). Boars reach sexual maturity at 7-8 months of age, although they reach their full reproductive potential at an older age. One of the most important reasons for the different ability of breeding boars to inseminate with sperm is genetic differences, primarily breed differences. Therefore, conducting research to study the dynamics of ejaculate parameters associated with sexual development in young boars of imported breeds is relevant. In this article, we assessed the rate at which boars reach full breeding maturity and their fertilizing ability by analyzing the parameters of ejaculates with age. After sampling, the ejaculate volume, sperm concentration and percentage of progressively motile sperm were taken into account. The physical parameters of the ejaculate change with the age of the boar. The dynamics of age-related changes in the physical parameters of ejaculates in Duroc boars is significantly lower compared to the Landrace and Yorkshire boar breeds. Duroc boars have better sexual development and differ from Landrace and Yorkshire boars, which are characterized by an earlier cessation of growth. Duroc boars reached their peak ejaculation 6 months earlier than Landrace and Yorkshire boars, at 23 -24 months of age. The most favorable course of sexual development was observed in Landrace boars. Both the volume of ejaculate and the number and motility of sperm in this breed dynamically increased with age. Regardless of the age of the animal, it was possible to prepare a larger number of spemodoses from the ejaculates of boars of a given breed, in contrast to analogues of other breeds.
Features of bacteriophage isolation in bovine keratoconjunctivitis
Authors: Pimenov N. V. , Ivannikova R. F. , Aiginin А. А. , Evteev N. A.
Published: January 2025

Infectious bovine keratoconjunctivitis is a highly contagious disease that is widespread in many countries of the world with developed dairy and meat farming, causing great economic damage. This is a contagious disease characterized by lacrimation, hyperemia of conjunctival vessels, photophobia, serous-purulent discharge, opacification and ulceration of the cornea, deformation of the eyeball in the form of keratoglobus or keratoconus, partial or complete loss of vision of the affected eye of the animal. The main causative agents of keratoconjunctivitis are Moraxella bovis and Moraxella bovoculi. Due to the development of multidrug resistance to various antimicrobial chemotherapeutic drugs, there is a need to search for alternative antibacterial agents, which can include bacteriophages. In this work, the goal was to isolate bacteriophages specific to Moraxella bovis and Moraxella bovoculi. For this purpose, 13 samples were selected from a livestock farm in the Moscow region. According to the results of the spot test, two bacteriophages were obtained from the samples, one had specificity only to Moraxella bovoculi, the second had lytic activity as to Moraxella bovoculi, and to Moraxella bovis. The activity according to the Appelman method ranged from 10-6 and 10-7 for Moraxella bovoculi and 10-4 for Moraxella bovis. According to the Grazia method, the yield was 3.2×107 ; 4×106 for M. bovoculi and 2×104 plaque-forming units for M. bovis. The specificity of the lytic spectrum was confirmed in cultures of Pseudomonas aeruginosa, Staphylococcus aureus and Pasteurella multocida.
The use of interfascial blocks for complex analgesia in the surgical resicrion of soft tissue tumors in the chest area in kompanion animals
Authors: Semenov B. S. , Nechaev A. Yu. , Nazarova A. V.
Published: January 2025

Achieving satisfactory results of surgical treatment of cancer patients is impossible without pain control both intraoperatively and in the early postoperative period. The inclusion of regional anesthesia in multimodal pain control protocols can significantly improve the quality of analgesia and accelerate patient recovery after surgery. Nevertheless, each method of interfascial plane block has its own indications, contraindications, and complications. The purpose of our study was to show the validity and effectiveness of the use of regional anesthesia in the form of interfascial plane blocks during surgical resection of soft tissue tumors in the chest area in companion animals. The study were included 49 animals (30 dogs and 19 cats) who underwent surgery resection of soft tissue tumors in the chest area. The criterion for the inclusion of animals in the study was the use of regional anesthesia in the form of interfascial plane blocks in the anesthesia protocol. As a result of the study, it was revealed that the combination of several interfascial blocks provides a significantly better level of analgesia in resection of volumetric formations in the early postoperative period, however, when performing a unilateral mastectomy, the combination of a transversus abdominis plane block with a erector spinae plane block does not reduce the postoperative pain level. In mastectomies involving the cranial mammary glands, the best result for postoperative anesthesia is shown by the use of serratus anterior plane block. The inclusion of interfascial plane blocks in the anesthesia protocol for oncological patients makes it possible to significantly reduce or eliminate the use of narcotic analgesics in the perioperative period and, accordingly, avoid side effects and complications associated with the use of narcotic drugs, which is especially important for debilitated and geriatric patients.
Epizootological investigation of an outbreak of emphysematous carbuncle in cattle (case study in the irkutsk region)
Authors: Meltsov I. V. , Blokhin A. A. , Sukhinin A. A. , Batomunkuyev A. S. , Kutuzova L. A.
Published: January 2025

Currently, one of the significant problems in animal husbandry, including dairy cattle breeding, remains the registration of acute diseases caused by clostridia. This work uses the results of an epizootological survey of an epizootic focus of an infectious disease of cattle and small ruminants in the Alarsky district of the Irkutsk region. Statistical processing of the results was carried out using a standard package of applied programs Microsoft Excel and methods of epizootological analysis. Thermostable microorganisms are sown from biological material, giving intense gas formation on the KittTarozzi medium, which indicates the presence of anaerobic bacteria in the pathological material. In smears of cultures isolated from biological material from dead animals, gram-positive rods with spores located subterminally are detected. The development of the disease in vaccinated animals may indicate both the ineffectiveness of the vaccine (this is confirmed by information from other regions) and the appearance of mutant variants of Clostridium chauvoei. The described epizootological features of the disease manifestation, clinical signs, pathological changes and results of primary laboratory tests allow us to diagnose emphysematous carbuncle. The measures taken by the Veterinary Service of the Irkutsk Region adequately ensure the localization of epizootic foci and the prevention of the spread of the disease beyond the affected area in accordance with the current veterinary regulations. Animal owners are recommended to take measures to improve the maintenance of animals: stopping winter grazing, feeding hay and in farmsteads, prohibiting the removal of unsterilized manure to public areas and grazing. However, these recommendations are not fully implemented due to the prevailing ethnic and cultural aspects of livestock farming.
POTENTIAL SOURCES OF BIOLOGICALLY ACTIVE SUBSTANCES IN OMSK REGION FOR THE CREATION OF PHYTOBIOTICS AND PHYTOGENICS
Authors: Boyko T. V. , Ogurnoy I. V. , Ogurnaya Yu. E.
Published: January 2025

The article presents analytical material on the study and application of plant materials as sources for the creation of phytobiotics and phytogenics for animal husbandry. Scientific articles in English and Russian with the keywords "phytogenics", "phytobiotics", "medicinal plants", "essential oil plants", "plants of the Omsk region" posted in bibliographic databases, in scientific electronic libraries of search engines were accepted as sources of literature. Publications of scientists of the Omsk region were studied in detail, on the basis of which it was established that more than 74 species of medicinal plants grow in the Omsk region, of which 30 have decorative, 27 honey, 17 medicinal and fodder values. The conducted analysis of scientific publications on potential sources of biologically active substances of plants growing in the Omsk region showed that the following wild plants are promising for the creation of phytogenics and phytobiotics: stinging nettle, calendula officinalis, yarrow, saltwort and oleaster angustifolia, the biologically active substances of which have a pleiotropic effect on the body, providing antibacterial, anti-inflammatory, hemostatic, immunomodulatory, antispasmodic, regenerating effects, as well as increasing the secretory activity of the glands of the stomach and intestines. The presented analysis of the chemical composition of saltwort samples growing in the Omsk region indicates the high nutritional value of plant materials and the need to study its effect on the functions of the animal body. A comparative analysis of the macroelement composition of halophyte showed that in June samples the content of magnesium, chlorine and nitrate anion prevails, while in samples collected in September the content of potassium, sodium, calcium and phosphates prevails, which must be taken into account when harvesting the plant.
INFLUENCE OF MELAMINE AND UREA ON MILK QUALITY INDICATORS
Authors: Kalyuzhnaya T. V. , Drozd A. V. , Almakaeva D. S. , Zhmurkina P. S.
Published: January 2025

The addition of melamine and urea to milk helps to increase the protein content, which is one of the main criteria for evaluating its quality. This is due to the fact that the determination of protein is directly related to its calculation by the non-protein and protein nitrogen determined by the Kjedal method, and melamine and urea contain nitrogen molecules in their composition. An interesting question is the effect of these adulterating components on milk quality indicators. The main method for determining these indicators is ultrasonic, implemented using milk analyzers. However, they do not provide for the determination of melamine and urea, which are determined by high-performance liquid chromatography and colorimetric methods, respectively. Therefore, it is not possible to detect the adulteration of milk with melamine and urea using ultrasonic analyzers. The aim of the work was to determine the effect of melamine and urea when added to milk quality indicators determined using an ultrasonic analyzer "Lactane 1-4". The work was carried out in stages on the basis of the educational and research center for the examination of food and animal Feed of the St. Petersburg State University of Veterinary Medicine. The objects for research were samples of raw milk with different concentrations of melamine and urea. Thus, the dependence of milk quality indicators on the concentration of urea and melamine in it has been established. At the same time, it was found that the higher the concentration of these substances in milk, the higher the value of its indicators such as mass fractions of protein, fat and density.
MODELING OF THE CALIBRATION DEPENDENCE FOR ESTIMATING THE MELAMINE CONTENT IN MILK USING AN IR FOURIER SPECTROMETER
Authors: Kalyuzhnaya T. V.
Published: January 2025

Promising methods of laboratory analysis, including the determination of the content of various substances in food products, include near- and medium-range infrared spectrometry, which allows the identification of chemical compounds. The method of IR spectrometry in the medium range is of the greatest scientific and practical interest, namely its application as an express analysis for the quantitative determination of the content of chemicals. There are few works in the scientific literature on the construction of calibration characteristics for IR-Fourier spectrometers in order to assess the safety parameters of milk, including melamine content. The aim of the work was to construct a calibration dependence for estimating the melamine content in milk using IR-Fourier spectrometers. The research was carried out in stages on the basis of the educational and research Center for the examination of Food and Animal Feed of the St. Petersburg State University of Veterinary Medicine. A standard sample of melamine, samples of raw milk without melamine and with melamine in various concentrations determined by high -performance liquid chromatography were used as materials for research. Based on the results obtained, a model of calibration dependence was built, which makes it possible to determine the quantitative content of melamine in milk at its pressure in order to falsify protein. The use of such models will allow not only the identification of chemicals, but also to determine their quantity, which is a promising direction in the development of new methods of physico-chemical analysis of food products and raw materials.
Development of the unified intestinal medium for microbiological research in veterinary medicine
Authors: Shebeko S. K. , Tikhmeneva Iu. A. , Sandulian K. V. , Ermakov A. M.
Published: January 2025

Artificial intestinal media are in high demand in microbiological research in the field of veterinary medicine, since they allow obtaining a qualitative and quantitative composition of microbiota corresponding to the natural conditions. The only artificial intestinal medium currently available in domestic microbiological practice has not been validated and its use is limited to the cultivation of lactobacilli. In this regard, the development of a unified artificial intestinal medium (UAIM) that best matches the natural conditions of the intestine, using the example of Brown Nick chickens, is of scientific interest for the effective cultivation of microorganisms during microbiological research in veterinary medicine. In the course of the studies, existing artificial intestinal media were analyzed and key components were selected, including pectin, xylan, arabinogalactan, amylopectin, casein, starch, bactopeptone, salts and vitamins, which ensures the reproduction of natural intestinal conditions. To test the effectiveness of the medium, ten samples of chicken feces were selected, five of which were incubated under UAIM conditions, and the other five were cultured without the use of the medium. The resulting bacterial cultures were identified and quantitatively analyzed using MALDI-TOF mass spectrometry and the method of seeding on selective media. Statistical analysis showed no significant differences in the microbiota composition between the experimental groups (p>0.05), indicating that the intestinal conditions were successfully reproduced using UAIM. This study demonstrates the potential of UAIM for culturing intestinal microbiota and can serve as a basis for further studies aimed at modeling intestinal conditions in the development of veterinary drugs and feeds.
EVALUATION OF THE EFFECT OF LAMINARIA GRITS ON THE PRODUCTIVITY OF LAYING HENS
Authors: Kochish I. I. , Zimin E. E. , Nikonov I. N.
Published: January 2025

A pressing issue in industrial poultry farming is the search for feed additives and technologies that facilitate the realization of the genetic potential of agricultural poultry. One of the solutions to this problem is molecular genetic methods for studying the expression levels of productivity and resistance genes, which allow us to assess the impact of feed additives on health, productivity and product quality at the molecular level. The purpose of the presented study was to assess the potential of using Laminaria grits as a feed in the diet of industrial layers of the Lohmann White cross. The experiment was conducted at the vivarium of the International Laboratory of Molecular Genetics and Genomics of Poultry, FGBOU VO MGAVMiB-MVA named after K.I. Skryabin. Zootechnical research methods were used in the work. The study found that the egg-laying intensity for the entire period was higher in the 2nd experimental group and amounted to 97.77%, which is 2.09% more than the control, 1.94% more than the third experimental group and 1.19% more than the fourth experimental group. In the group of birds receiving bladderwrack, the indicator was at the level of 96.88%, which is 1.2% more than the control and 0.3% more than the fourth experimental group. The introduction of 15 g / kg of kelp contributed to an increase in the egg-laying intensity by 0.9%, compared to the control. Thus, in the course of the study, the effect of different rates of introducing Laminaria grits as a feed was assessed. The maximum egg production of 97.7% was noted with the addition of Laminaria to the feed (5 g / kg), which is 2.1% higher than the control. The results of the experiment form the basis for the development of new promising natural adaptogens that normalize the productivity of industrial cross-breed laying hens and ensure the production of biosafe poultry products.
FLEXORS OF THE ELBOW JOINT IN SOME REPRESENTATIVES OF THE CARNIVOROUS ORDER (CARNIVORA)
Authors: Kukhareva T. P. , Bylinskaya D. S.
Published: January 2025

Representatives of the predatory order have a similar anatomy of elbow flexors. However, due to the difference in lifestyles of individual predatory species, the abovementioned muscles are involved in the movement of the elbow joint in different ways. Using the basic principles of biomechanics allowed us to study the effect of each muscle at a certain point in the angle of the elbow joint. The material for the study was the corpses of a raccoon, raccoon dog and Mestizo dogs (weight 7-10 kg), delivered to the Department of Animal Anatomy from veterinary clinics in St. Petersburg and hunting farms in the Leningrad region. The research method was fine anatomical dissection. The moment of force is a physical quantity that is the product of the modulus of the force rotating the body by its shoulder and the sine of the angle between the shoulder and the modulus of force. Since sin(90º) =1, we built a perpendicular from the center of the axis to the force vector and this value was taken as the Moment Arm (MA). The fulcrum or center of the axis in this case is the center of the elbow joint. The force is represented as a vector, the direction of which is determined depending on the function of the muscle. The vector is based on the points of attachment of the muscle. Using the tpsDig2 program, we measured the Moment Arm of the muscles at different values of the angle of the elbow joint. The peak of the brachialis muscle in a raccoon stripper is at 72°, in a raccoon dog, the brachialis muscle is slightly involved in flexion of the elbow joint. The circular pronator in all individuals is weakly involved in flexion of the elbow joint. We have identified the biceps muscle of the shoulder and the shoulder muscle as the "main" flexors of the elbow joint, because at any value of the angle of the elbow joint, the muscles adhere to medium and high values. In dogs, the maximum range of motion of the elbow joint (MDD) is from 57° to 149°, in a raccoon from 45° to 158°, in a raccoon dog from 75° to 130°.
THE USE OF TARGETED SEQUENCING FOR GENOTYPING SHEEP OF THE MANYCH MERINO BREED
Authors: Krivoruchko A. Yu. , Kanibolotskaya A. A. , Skorykh L. N. , Safaryan E. Yu. , Krivoruchko O. N.
Published: January 2025

The main use of genetic data is to assess the reliability of origin, since errors in pedigrees negatively affect the rate of genetic growth. Initially, the assessment of the pedigree of breeding livestock was carried out using various DNA technologies: from blood groups, then using microsatellite markers, however, now the possibility of using single nucleotide polymorphisms (SNP) in practice is being increasingly studied, due to their ability to increase the accuracy of genetic research. One of such genotyping systems is AgriSeq panels (targeted sequencing technology), which allow analyzing specific regions of the genome (loci) associated with a variety of traits in animals. The purpose of the work: to study the effectiveness of identifying and prevalence of loci from the proposed set of SNPs in the examination of new generations of sheep of the Manych Merino breed. The material for the study was data from targeted sequencing of the genomes of Russian sheep breeds according to the formed set of loci in order to identify singlenucleotide polymorphisms. The object of the study was sheep born in 2021 at the age of 12 months (DNA sampling was carried out in 2022) of the Manych merino breed. The proposed locus panel, modified after validation on the next generation of animals, contains 389 substitutions suitable for genotyping by sequencing and 242 polymorphisms associated with animal meat productivity. The indicators of the frequency of occurrence of substitutions in the group of selected animals obtained as a result of research allow us to conclude that the polymorphisms, we have selected are located in loci that are not subject to significant rearrangements for several generations and can be informative for quite a long time. The analysis allows us to conclude that after modification of the set of loci, the panel for genotyping by sequencing in the Manych merino showed high efficiency in identifying all variants of genotypes.
CONCENTRATION OF STEROID AND GONADOTROPIC HORMONES IN THE BLOOD SERUM OF FEMALE REINDEER IN THE LATE PREMAILING AND EARLY POSTPARTUM PERIODS
Authors: Krutikova A. A. , Shiriaev G. V. , Nikitkina E. V. , Peglivanian G. K. , Musidray A. A. , Nikitin G. S.
Published: January 2025

Despite the fact that reindeer (Rangifer tarandus) are an important commercial species for providing food for the population in difficult living conditions, they are currently poorly studied due to the complexity of conducting research. This is especially true for physiological characteristics associated with reproduction, the gaps in which complicate the implementation of modern assisted reproductive technologies. Deep knowledge of endogenous hormonal regulation in different physiological periods of female reindeer could allow us to manage the reproductive function. The work is devoted to the analysis of concentrations of steroid hormones 17β - estradiol and progesterone, as well as gonadotropins - follicle-stimulating and luteinizing hormones of females during the breeding season. The object of the study were female (female) reindeer (n = 31). The habitat is a reindeer farm in the north of Western Siberia, in the Yamalo-Nenets Autonomous Okrug of Russia. The total sample was divided into two groups: group 1 (n=16) did not calve and group 2 (n=15) did. The hormone levels in the blood serum were determined using enzyme immunoassay. The results of the studies show that in the group of does in the late calving period, the concentrations of estradiol and progesterone were significantly higher (p<0.01) compared to the group of does after calving. At the same time, a tendency towards an increase in follicle-stimulating hormone can be noted after calving. A negative correlation was recorded in the case of progesterone and luteinizing hormone in the group of does in the early calving period (r=-0.735, p<0.01). A positive correlation was found between follicle-stimulating and luteinizing hormones (r=0.811, p<0.01). In the group of animals in the late calving period, a positive correlation was found between progesterone and estradiol (r=0.641, p<0.01). The results obtained suggest that in female reindeer, the resumption of sexual cycles occurs according to a similar hormonal scenario, in which the level of steroid hormones decreases after calving, and the concentration of gonadotropic hormones, on the contrary, gradually increases with higher FSH dynamics, compared to LH.
FEATURES OF THE LEVELS OF SEX HORMONES IN FEMALE REINDEER (RANGIFER TARANDUS) AT DIFFERENT STAGES OF THE ESTROUS CYCLE
Authors: Krutikova A. A. , Belikova A. O. , Peglivanian G. K. , Shiriaev G. V. , Nikitkina E. V. , Musidray A. A. , Bogdanova S. S.
Published: January 2025

Reindeer (Rangifer tarandus) are a polycyclic animal species with a limited breeding season. Although the main reproductive season for reindeer occurs in autumn, the onset of this period varies even within one geographical area, which is due to feeding factors related to the fatness of animals, as well as temperature, light and other climatic conditions. Therefore, a thorough understanding of the female reindeer reproductive cycles is important for managing reproductive processes, including through assisted reproductive technologies, and increasing the productivity of populations. Hormone levels is a critical aspect in the practice of artificial insemination of animals, since hormonal status has a significant impact on reproductive functions. The aim of our study is to study the hormones concentration: estradiol, progesterone, luteinizing hormone (LH) - in the blood of female reindeer in summer and autumn. The object of the study were clinically healthy female domestic reindeer (n = 3), that live in Pushkin. Blood was taken from June to October, the time interval between blood sampling was on average 1 week. The level of hormones was determined using enzyme immunoassay. Based on changes in LH and progesterone levels, the estrus cycles in the studied animals occurred from July to late October. The dynamics of changes in LH levels at the beginning of the rut season differed in all three animals. In all animals, cyclic increases in progesterone were observed on average every 14 days with the onset of the rut season. All the studied hormones in reindeer female demonstrated moderate and weak reliable correlations.
Patient-Provider Satisfaction and Combination Antiretroviral Therapy Adherence: An Analysis of the Association Between Health Care Satisfaction and Adherence, as Framed by the Health Belief Model
Authors: Graham Grace , Ware Deanna , Plankey Michael
Published: January 2025

Background

Health care satisfaction can be used as an indicator of beneficial health outcomes. For people living with HIV (PLWH), reduced morbidity and mortality depend on adherence to combination antiretroviral therapy (cART). It is integral to assess whether health care satisfaction improves outcomes in individuals with HIV through strengthening adherence. The goal of this study was to investigate the association between health care satisfaction and cART adherence as framed by the health belief model.

Methods

This analysis used data from the Multicenter AIDS Cohort Study, a longitudinal observational cohort study. Cross-sectional data were collected from the 656 participants in the Understanding Patterns of Healthy Aging Among Men Who Have Sex With Men substudy from October 2016 to March 2019. The association between health care satisfaction and adherence was examined using logistic regression. In the adjusted model, covariates were age, race and ethnicity, source of medical care, insurance status, comorbidity count, and education.

Results

Most participants in the study were highly adherent to treatment, with 87.96% of the sample having adherence levels of 95% or greater. Increased health care satisfaction was significantly associated with 95% or greater adherence in both a multivariate model (adjusted odds ratio per unit increase, 1.12 [95% CI, 1.04-1.21]).

Conclusions

Health care satisfaction was positively associated with treatment adherence. This suggests that interventions to improve health care satisfaction should focus on training physicians to facilitate trusting and supportive communication about patient adherence as a method of addressing potential barriers to consistent cART usage.
Marketing Mix and Consumer Purchase Decision of Fast-Moving Consumer Goods (FMCG) in Akwa Ibom State, Nigeria
Authors: B. Attih Okokon
Published: January 2025

This study was conducted to examine the effect of marketing mix on the consumer purchase decision of fast-moving consumer goods (FMCG) in Akwa Ibom State, Nigeria. The survey research design was used in this study. Data for the study were obtained through a structured questionnaire administered to the respondents. The population of the study comprised all the consumers of fast-moving consumer goods (FMCG) in Akwa Ibom State. The sample size of 308 respondents were selected using convenience sampling technique. Four hypotheses were formulated and tested using Spearman Correlation at 0.05 level of significance. The findings of the study revealed that there is a positive and significant relationship between marketing mix-product, price, place, promotion and consumer purchase decision of fast-moving consumer goods (FMCG) in Akwa Ibom State, with the correlation coefficient (r = 0.479), (r =0.573), (r = .0.720) and (r = 0.623) respectively at the significant value of 0.000 (p>0.05). Therefore, it is concluded that marketing mix plays an important role in influencing the consumer purchase decision of fast-moving consumer goods (FMCG).
Hyperplastic processes of endometrium: clinic of different forms early in life
Authors: Leshchova Olga
Published: January 2025

The objective: to set the clinical features of different forms of hyperplastic processes of endome-trium for the women of young age taking into account the role of chronic endometritis.Materials and methods. It was conducted clinical-and-laboratory inspection 100 patients to 30 years with the uterine bleeding of different character and presence of echographic signs of pathology of endometrium.Results. The analysis of the got data testifies that more frequent all gynaecological diseas-es met for patients with simple hyperplasia of endometrium without atypia in combination with chronic endometritis and women with chronic endometritis and reactive hyperplasia is of high quality pathology of servix (80,0% and 75,0% respectively), violation of menstrual cycle (90,0% and 75,0%), urogenital infection (85,0% and 95,0%). In addition, in these groups of supervisions the most of cases is marked verified earlier chronic endometritis – 10,0% and 20,0%. Conclusions. For the patients of young age with combination of hyperplasia of endometrium and chronic endometritis and with reactive hyperplasia, as compared to hyperplasia without atypia and with atypia, more early beginning and expressed of clinical symptoms of disease, duration of which exceeds 2 years, is marked. For women from an outage and difficult typical and atypia hyperplasia connection between the morphological variant of pathological process and pathog-nomonic clinical no symptoms. In the structure of concomitant diseases for patients the inflammatory processes of organs of small pelvis prevail (as compared to hyperplasia without atypia and with atypia) with the pres-ence of chronic endometritis, the of high quality diseases of servix, hyperplastic processes of endometrium which testifies to the expressed system character of pathology. The got results must be taken into account at development of algorithm of diagnostic and treatment-and-prophylactic measures for women with the hyperplastic processes of endometrium, including, and on a back-ground chronic endometritis. Keywords: hyperplastic processes of endometrium, young age, clinic, different forms.
Comparative aspects of different methods surgical treatment of the combined pathology of uterus
Authors: Netskar Iryna , Kovalishin Orysya
Published: January 2025

The objective: to learn the comparative aspects of different methods of surgical treatment of the combined pathology of uterus. Materials and methods. 362 women are plugged in research, that has signs of adenomyosis and uterine fibroids. To the operation the followings symptoms served certificates: subjective complaints of patient about a pain syndrome, irregular bloody protracted excretions (bleeding) from sexual ways, abdominal discomfort, related to disfunction of nearby with an uterus organs. At laboratory control to the basic certificates the presence of protracted chronic anemization served to operative interference, to the uncomplying pharmacological correction. In an obligatory order to all patients ultrasonic research of organs of small pelvis was conducted with the coloured Doppler lodging of uterine vessels.
Results. It is discovered that increase of volume of organ which retires, the risk of damage of urinoexcretory ways increases time of operation laparoscopic access (р<0,05). The use of vaginal access is increased by the risk of forming of dispaurenia for patients with the large organ size which retires, and at the increase of time of operation (р<0,05) which can be constrained from traumatisation tissue at the oncotomy of large size and greater blood loss at lengthening of time of operation. Consequently, there are grounds to draw conclusion about the necessity of bringing of limitations of the use of littleinvasion accesses at the large size of tumour of uterus. At the sizes of tumour more than 14 weeks, in behalf of patient it is expedient to use transabdominal access in order to avoid heavy intraoperative complications, bleeding and negative symptoms in a late postoperative period, related to forming of proof pain syndrome and forming of dispaurenia.Conclusions. The results of the conducted researches testify to the necessity of the use of the differentiated going near the use of different methods of surgical treatment (abdominal, laparoscopic and vaginal) for patients with combination of uterine fibroids and endometriosis. Rational use of modern methods of operative treatment taking into account age of patients, sizes of tumour, presence of concomitant extragenital pathology and others like that will allow to reduce frequency of early and late postoperative complications, and also instrumental in more rapid renewal of patients.Keywords:combined pathology of uterus, surgical treatment, comparative aspects.
Diagnostics and tactic of delivery is at decompensated placenta disfunction
Authors: Prishchepa Andrey
Published: January 2025

The objective: decline of frequency of perinatal pathology for women with the decompensated form of placenta disfunction by the improvement of basic diagnostic and treatment-and-prophylactic measures. Materials and methods. By us it was inspected 154 pregnant in the terms of gestation from 22 to 40 week. Depending on the features of motion of pregnancy and births of all inspected women it was up-diffused on 4 groups. The group of retrospective analysis was made 45 pregnant with a decompensated form, to the group of prospective research entered 109 pregnant, from them a basic group was made by 38 women with a decompensated form, in the group of comparison entered 47 pregnant with the compensated form. A control group was made 24 pregnant with uncomplicated motion of pregnancy and births. To the complex of the conducted researches were included clinical, echographic, doppler, laboratory, morphological and statistical methods. Results. The perinatal consequences of delivery of women with a decompensated form are characterized by the grave condition of new-born, that in 50,0% requires the leadthrough of artificial lung ventilation. The basic forms of pathology is hypoxic-ischemic damage of central nervous system of different degree of severity (87,5%); intrauterine hypotrophy (80,9%); syndrome of respiratory disorders (71,4%); extremely low body weight (46,7%), intrauterine infecting (50,0%) and hemorragic syndrome (46,7%). Frequency of postnatal losses is 6,1%, and leading reasons is deep prematurity, hypoxic-ischemic damage of central nervous system of heavy degree, development of disseminated intravascular blood coagulation and multiple organ failure.Conclusions. Decompensated placenta disfunction is one of principal reasons of perinatal mortality and morbidity on the modern stage. The use of the algorithm of diagnostic and treatment-and-prophylactic measures improved by us allows to select the basic factors of risk of this complication and testimony for the change of tactic and terms of delivery.Keywords:placenta disfunction, decompensation, diagnostics, pregnancy, complication.
Influence of different volume of hysterectomy is on the state of the vegetative nervous system and quality of life of women of perimenopausal age
Authors: Vdovychenko Sergij
Published: January 2025

The objective: to learn influence of hysterectomy of different volume on the state of the vegetative nervous system and quality of life of women of perimenopausal age, and also possibilities of correction of these violations. Materials and methods. 150 women of perimenopausal period, middle age of which made 46,9±1,1 years, were inspected. to 120 women with different gynaecological diseases was perfomed hysterectomy, thus a 1 clinical group was made by 60 patients which was executed hysterectomy without appendages; 60 patients after hysterectomy with appendages were 2 clinical group, and in the group of control 30 women entered without operative treatment in anamnesis. Possibilities of correction of violations from the side of the vegetative nervous system women after hysterectomy had studied in 40 patients which had those or other vegetative changes: 15 women made a group A also 25 – group B. For the correction used two variants: gestagens (livial) or estrogen (divigel). The complex of methods of researches included clinical instrumental, laboratory, psychological and statistical. Results. At research of the vegetative providing a normal level found out in 20,0% and 13,3% respectively on groups. The surplus providing of activity found out in 26,7% and 23,3%. As compared to it considerably more frequent there was the insufficient vegetative providing – 53,3% and 63,3% respectively. The results of the conducted researches testify that the use of hormone-replacement therapy during 3 months allowed to normalize activity of the vegetative nervous system in 20,0% patients, and in 6 months – respectively in 36,7%. In addition we succeeded to reduce frequency of syndrome of vegetative dystonia from 66,7% to 43,3% in 3 months and to 23,3% – in 0,5.Conclusions.The changes of the state of the vegetative nervous system depend on the volume of the carried operative interference and carry the expressed enough character. Specifies findings on the necessity of development of complex of rehabilitation measures for patients which carried hysterectomy, thus taking into account nascent violations from the side of the vegetative nervous system and quality of life. The use of different variants of hormone-replacement therapy allows to reduce the degree of expressed of violations of the vegetative nervous system improvement of quality of life for the patients of this group.Keywords: hysterectomy, vegetative nervous system, quality of life, perimenopausal age.
Women have features of pathology of cervix with a metabolic syndrome
Authors: Kostyuk Irina
Published: January 2025

The objective:the women of reproductive age have determination of structure of pathology of cervix at a metabolic syndrome.Materials and methods. In research women joined in age from 18 to 49 years with a diagnosis metabolic syndrome, set after the criteria of IDF, in 2020. 47 women are inspected from metabolic syndrome of reproductive age (middle age 31,3±1,2 years). To the complex of methods researches were included clinical, laboratory, instrumental, cytological, morphological and statistical.Results. The results of researches testify that in 28 (59,6±5,8%) patients with a metabolic syndrome found out the normal colposcopic states. From them there was the unchanged squamous epithelium in 5 (17,9±1,3%) women, in 7 (25,0±2,2%) is an ectopia of cylinder epithelium, in 16 (57,1±5,4%) is the uncompleted area of transformation. At cytological research in 29 (61,7±6,1%) women found out the II type of cytological changes – signs of chronic inflammation on a background which there were the anomalous colposcopic states in 14 (29,8±2,9%) patients. For all women with a atypical colposcopic picture the uncompleted area of transformation was presented by the areas of acetowhite epithelium with clear, by iodine-negative circuit after the test of Shilera. Thus, in 6 (42,9±4,2%) women with such found out colposcopic results a „delicate mosaic”, in 4 (28,6±2,1%) is a „delicate punctuation”, in 1 (7,1±0,9%) is a „rough punctuation”, in 3 (21,4±1,9%) is combination of „delicate mosaic” and „delicate punctuation”. Conclusions. The analysis of the got results did not find out reliable differences in frequency and structure of colposcopic visualization of pathology of epithelium of cervix for healthy women and for patients with a metabolic syndrome. It can testify that genesis of pathological changes of exocervix is determined in a greater measure by the presence of pathogen, in particular to the human papilloma virus, than hormonal adjusting. However for patients with a metabolic syndrome with the purpose of prophylaxis of pathology of cervix, along from cytological screening, it is expedient to conduct colposcopic research, taking into account the high risks of persistence of human papilloma virus on a background dishormonal pathology.Keywords:pathology of cervix, structure, metabolic syndrome.
Features of vaginal smear microscopy in women with recurrent vulvovaginal candidiasis
Authors: Ratushniak Nataliia
Published: January 2025

The objective: to determine the features of the vaginal microbiota in patients with recurrent vulvovaginal candidiasis (RVVK).Materials and methods.A prospective study and clinical and laboratory analysis of vaginal microbiocenosis in women with RVVK were conducted. The main group (MG) consisted of 70 women of reproductive age with recurrent vulvovaginal candidiasis and 40 healthy women of reproductive age who made up the control group (CG). The scope of the study - evaluation of the microbiocenosis of the vagina according to the data of the smear microscopy, stained according to Gram, cultural study of vaginal secretionsResults.It was established that 52 (72.8%) women were diagnosed with the classic variant of vulvovaginal candidiasis (VVK), when yeast fungi grow against the background of normal microflora, i.e. absolute dominance of lactobacilli. In 18 (25.7%) patients, a combination of VVK and bacterial vaginosis (BV) was detected. Surface cells predominated among epithelial cells (100.0% in 70 women), in 51 patients (72.8%) surface cells were combined with intermediate cells. Parabasal epithelial cells were found in 2 patients (2.8%). Background microflora in patients with VVK was homogeneous, lactobacilli morphotypes dominated, in women with a combined form of VVK with BV, anaerobes and Gardnerella morphotypes prevailed. In patients with RVVK, a moderate and pronounced leukocyte reaction prevailed, which was observed in 66 (94.2%) cases, in 4 (5.7%) women, leukocytes were absent or were single in the preparation.Conclusions.With RVVK, the total number of microorganisms in 19 (27.2%) patients was moderate and ranged from ll to 102 microbial cells in the field of vision, in 33 (47.1%) – large – 102 – 103 microbial cells in the field of vision. In patients with a combined form of IVC, the number of microorganisms exceeded 103 microbial cells in the field of view, moderate and pronounced leukocyte reaction also prevailed, which was observed in 66 (94.2%) cases. The most frequent causative agent of candidal infection is S. albicans (84.2%), followed by Candida glabrata (11.4%).The research was carried out in accordance with the principles of the Helsinki Declaration. The study protocol was approved by the Local Ethics Committee of the participating institution. The informed consent of the patient was obtained for conducting the studies.Keywords: state of vaginal microbiocenosis, vulvovaginal candidiasis, vaginal smear microscopy, microbial cells, candidal infection.
Self-Destructive Nanoparticles of Drug Delivery
Authors:   Department of Pharmaceutical Chemistry, CMR College of Pharmacy, Kandlakoya (V), Medchal, Hyderabad-501401, Telangana, India., Sangeetha M
Published: January 2025

This review is provided a detailed information about the introduction, mechanisms of self- destructive nanoparticles, benefits of nanoparticles, future perspectives and different types of applications of self-destructive nanoparticles