bluuebunny/crossref_metadata_2025 huggingface dataset:
Nanoparticle Targeting with Antibodies in the Central Nervous System
Authors: Lee Ju Hyun , Chapman Dana V. , Saltzman W. Mark
Published: March 2023

Treatments for disease in the central nervous system (CNS) are limited because of difficulties in agent penetration through the blood-brain barrier, achieving optimal dosing, and mitigating off-target effects. The prospect of precision medicine in CNS treatment suggests an opportunity for therapeutic nanotechnology, which offers tunability and adaptability to address specific diseases as well as targetability when combined with antibodies (Abs). Here, we review the strategies to attach Abs to nanoparticles (NPs), including conventional approaches of chemisorption and physisorption as well as attempts to combine irreversible Ab immobilization with controlled orientation. We also summarize trends that have been observed through studies of systemically delivered Ab–NP conjugates in animals. Finally, we discuss the future outlook for Ab–NPs to deliver therapeutics into the CNS.
Identifying Ecological Priority Areas for Synergistic Conservation across Scales in the Asian Water Tower Region
Authors: Zhou Guangjin , Huan Yizhong , Wang Lingqing , Zhang Riqi , Liang Tao , Dunn Matilda Eve , Yao Fuqi , Tong Yali
Published: March 2023

The region containing 17 Asian countries located on and around the Qinghai-Tibetan Plateau (Asian Water Tower) is experiencing a serious ecological crisis, representing a major challenge for both Asian and global ecological conservation. Identifying and synergizing multiscale ecological conservation priorities for this region can promote progress toward the goals proposed by the post-2020 global biodiversity framework (e.g., protecting 30% of the planet) and Sustainable Development Goal 15 (life on land). We mapped the importance of and interactions among 5 key ecosystem services (ESs) (water conservation, carbon sequestration, sand fixation, soil conservation, and biodiversity conservation) across this region and identified areas where synergistic ESs were present. We further identified synergistic national- and regional-scaled conservation priority areas. The areas with “high importance” of the composite ESs accounted for 18.9% of the total region. Seventy-two percent of this area was found to have an overlap of at least 2 ESs. Approximately 33.3% of the study region was identified as a regional-scaled conservation priority area, which can be implemented synergistically in each country. Approximately 22.5% of the land in the priority area was nonecological land, which can seriously compromise the importance of ESs. A set of actions to support achieving global conservation goals, such as strengthening the control of anthropogenic activities in priority conservation areas, providing additional efforts and assistance to some key countries, and developing effective ecological compensation schemes, was provided.
Research Trends on the Use of Technology in Early Childhood Science Education: Bibliometric Mapping and Content Analysis
Authors: Aktaş İdris
Published: March 2023

The purpose of this study is to identify research trends from 2011 to 2020 through bibliometric mapping and content analysis of articles on the use of technology in early childhood science education. Articles published between 2011 and 2020, identified through the Web of Science database, constituted the data for the research. For bibliometric mapping and content analysis, this study accessed a total of 47 articles that met the inclusion criteria for science education, early childhood, and technology. The results revealed that the number of articles has increased over the years; that academic achievement,identifying the teaching environment features, and determining teacher experiences were the most examined variables; and that STEM hands-on activities, robotics-programming, and ICT tools such as tablets and computers have been the most- popular technology types. The studies on the use of technology in ECSE are at a developmental stage. Future studies may focus on different variables such as cognitive issues, collaborative activities, and interactions, and on various new technologies such as coding, augmented reality, digital apps, web 2.0, and e-portfolio. They may also focus on increasing the competence of pre-service teachers in the use of new technologies for pedagogical purposes.
Investigation of Primary School Music Education Repertoire in Terms of Music Terminology
Authors: Lehimler Eren
Published: March 2023

The aim of this study was to conduct a terminological examination of the songs and folk songs in primary school Music course books through the musical notes. Based on the statement that music theory, musicality and music aesthetics should be offered to primary school children, the musical notes in the coursebooks were examined under the titles of Tempo, Break and Pause, Dynamics, Articulation, Expression, Repetition and codas. Case study method, one of qualitative research designs, was adopted in the study. A total of 126 songs and folk songs included in 1st, 2nd, 3rd and 4th Grade Music coursebooks published by the Ministry of National Education in 2018-2019 were investigated. Document analysis was used in data analysis. One book for the 1stGrade Music course (21 musical works), two different books for the 2ndGrade Music course, one was published in 2018 (21 musical works) and the other in 2019 (22 musical works), two different books for the 3rdGrade Music course,both published in 2019 (21 and 18 musical works) and one book for the 4thGrade Music course(23 musical works) were published and distributed.2nd and 3rd Grade Music coursebooks, which had two different editions, differed according to the region and schools. The results showed that the terms and symbols of tempo, breaks, articulation, expression, ornaments, accent, repeat, which form the basis of the music, were not included sufficiently, the musical expressions intended to be taught were not reinforced and the international music terminology was not followed. In addition, it was found that although the musical notes were presented in the coursebooks, they were not explicitly shown to the students, and even the teachers were directed to videos instead of using musical notes. In addition, it was found that the end-of-unit evaluations did not consist of questions related to music terminology, and no definition of music terminology was presented in the glossary section at the end of the coursebooks. As a result, it was concluded that the coursebooks cannot go beyond activity planning due to the lack of a teaching on music theory and that the mistakes related to music terminology in the musical works can disrupt music education.
Implementation of Strategy Instruction to Promote Pre-Service Chemistry Teachers’ Self-Regulated Learning Skills
Authors: Ekici Funda , Atasoy Basri
Published: March 2023

This study aimed to promote self-regulated learning skills in pre-service teachers, and to this end, a two-year Self-Regulated Learning Skills Development (SLSD) Plan for pre-service chemistry teachers was developed. In this SLSD plan, the strategy instruction was conducted in an integrated way into the content courses of the chemistry education curriculum. The strategy instruction was carried out in four parts: “time management strategies”, “reading comprehension and summarization strategies”, “writing strategies” and “questioning strategies”. In addition, metacognitive strategies used by the pre-service teachers during the strategy instruction were also examined. Semi-structured interviews, self-monitoring forms, field notes, and student-generated questions were used to collect data to identify the strategies that the pre-service teachers used and determine the changes that occurred as a result of the application of these strategies. The data were analyzed using descriptive and content analysis methods. It was determined that both the frequency of use and the diversity of the strategies used increased in time management strategies, reading comprehension and summarizing strategies, and writing strategies. In questioning strategies, when the quality of the questions created by pre-service teachers was examined, it was determined that there was an increase in the quality of these questions in terms of “thinking level” and “content”, but there was no regular trend in terms of “chemistry understanding levels”. It was observed that most of the pre-service teachers also applied metacognitive strategies during strategy instruction. In the light of the results of this study, suggestions on promoting self-regulated learning skills in pre-service teachers are provided for chemistry teacher education, and chemistry education researchers.
The Purposes and Justifications for Preferences of Web 2.0 Tools Used by Pre-Service Chemistry Teachers in Their Teaching Practices in Distance Education Environment
Authors: Gencer Sinem , Turan-Oluk Nurcan , Kadayifci Hakki , Yalcin Celik Ayse
Published: March 2023

Due to the COVID-19 pandemic, mandatory changes were required in the field of education, as in many other fields. One of these fields is a teacher training programme, which includes teaching practice. It has become of great importance that pre-service science teachers, who frequently include experiments in their teaching practices in face-to-face education, will carry out this process in online education. This process, experienced due to the COVID-19 pandemic, prompted pre-service science teachers to find something that could replace the wet labs. One of the solutions in this situation is for them to choose and use appropriate Web 2.0 tools in their online lab teaching practices. Therefore, the purpose of the study was to examine the Web 2.0 tools used by pre-service chemistry teachers in their online teaching practices in a distance education environment, the purposes of using these tools, and their justifications for preferences to use these tools. This study was conducted with 15 pre-service chemistry teachers. Data were collected via observations, a form filled out by the participants, and semi-structured interviews in this study. According to the results of this study, it was determined that the participants used 17 Web 2.0 tools during their online teaching practices. The findings highlighted that the most used Web 2.0 tools were Perculus+ chat, Google docs, and Quizizz. Moreover, it was determined that the participants used these tools for 21 different purposes such as drawing students’ attention, getting hypotheses, and designing experiments. The results also indicated that the participants emphasised the ease of the Web 2.0 tool as a justification for the preference for almost all of the Web 2.0 tools they use, regardless of their purposes for using these tools. It is thought that the results can be used to show how to make online or face-to-face teaching practices in teacher training programmes by using Web 2.0 tools more effective in the future.
Attitude of Educationalists on Implications of Value-Void Education in Creating Tunneled Individuals: A Case Study of Elizabeth Holmes and Annie Dookhan
Authors: Nair Harshith B , C Padmaja
Published: March 2023

Value-oriented education has been an integral facet of education. The need for value education stems from the social malaise in the society and education, being purposeful in making students responsible citizens, must address such deficiencies in values. This study aims to understand the attitude of student teachers and in-service teachers’ towards current education and its value systems and seeks their stand on requiring value-oriented education as they are the major stake holders of direct classroom education experience other than students. The case study of Elizabeth Holmes and Annie Dookhan was used to assess how academically strong individuals end up straying into fraudulent ways. The study was administered using an electronic questionnaire, the frequency range was established using SPSS and indexed to percentage values. The data shed light on the attitude of student teachers and in-service teachers feeling that current education fails to inculcate values and suggested some methods of reform in the value systems of current education.
An Investigation on the Technological Competency Self- Evaluation Levels of English Language Teachers
Authors: Şahin Kerem , Yelken Tuğba Yanpar
Published: March 2023

This study was conducted to determine the technology competency self-evaluation levels of English Language Teachers and their opinions on the subject. The mixed method, in which qualitative and quantitative research designs were used together, was used in the study. The data of the research was collected using data collection tools including scale and open-ended questions. The research covers English Language Teachers working in Aksaray province in the 2020-2021 academic year. The sample of the study consists of 303 English Language Teachers working in primary, secondary and high schools in Aksaray. Teachers’ technology self-efficacy assessment capacities were determined by taking their opinions with the help of Technology Competence Self-Evaluation scale. It was tried to determine teachers’ technology use capacities, the problems they face and solution offers by means of open-ended questions prepared by the researcher. The data gathered was analysed through t-tests and one-way Anova via SPSS programme and the opinions obtained from open-ended questions were analyzed through content analysis. As a result of research, it was found that Technological Competency Self-evaluation Levels of English Language Teachers is high and their self-efficacy does not make a significant difference in terms of professional seniority, teachers’ levels of academic work, going to technology course and using platforms like eTwinning, web 2.0. It was determined that teachers used technology as Education and Training environment, they used it on the purpose of assessment and evaluation at the lowest level, the teachers who have higher professional seniority have much more difficulties. It was also determined that they face the problems such as infrastructure, internet access problems and illiteracy. It was confirmed that teachers should take in-service training courses as a solution.
The effect of HIV protease gene mutations to protease inhibitor drugs resistance in Papua patients: In silico analysis
Authors: Widiyanti Mirna , Maladan Yustinus , Adiningsih Setyo
Published: March 2023

The use of phenotypic assay requires laborious work to culture HIV isolates to observe the phenotypic change of the virus in the presence of antiretroviral drugs. The genotypic approach may rely on the secondary data of documented mutations that are responsible for phenotypic alterations to antiretroviral-resistant HIV. HIV genomes were extracted from patients’ plasma, which was subsequently subjected to RT-PCR and Sanger sequencing. The obtained HIV genome sequencing data were analyzed for mutation detection. Three-dimensional (3D) structures of mutant HIV protease were constructed using FoldX software. The binding affinity of the mutant HIV protease with protease inhibitor drugs (Saquinavir, Ritonavir, Nelfinavir, Indinavir, and Lopinavir) was analyzed using AutoDock Vina. There were 90 patients involved in this study. The patients attended the Voluntary Counseling Test (VCT) of Mitra Masyarakat Hospital in Mimika, Papua, Indonesia. Among recruited subjects, the HIV genomes corresponding to the protease-encoded gene of 30 patients were successfully sequenced. There was only one patient (RSMM_70) infected with HIV harboring minor mutations (L10V, I15V, M36I, and R41K) in the protease-encoded gene that was not a new finding mutation. The 3D structure showed that the hydrophobicity and stability of mutant HIV protease were different from the wild genotype. Docking analysis showed decreasing binding affinity of the mutant HIV protease to the protease inhibitor drugs, which may lead to the alteration of inhibitory effectiveness. In silico docking, the analysis may provide an alternative approach to predict the effect of minor mutations in the HIV protease gene on the effectiveness of protease inhibitor drugs.
Gender specifics of depressive disorders combined with autoaggressive behavior
Authors: Koltsova H.H.
Published: March 2023

A comprehensive analysis of depressive disorders combined with autoaggressive behavior, taking into account gender specifics was conducted according survey results of 147 patients of both sexes. Gender features of the clinical structure of depressive disorders have been established. Anxious and emotionally labile variants are more common in women, astheno-apathetic and obsessive variants are for men, melancholy variant occurred with approximately the same frequency in both groups. The clinical picture of depressive disorders in men was characterized mostly by feelings of grief, daily mood swings, indifference, fears and obsessive memories, narrowing the range of interests; the clinical picture of depressive disorders in women was characterized by the idea of self-blame, guilt, inferiority, psychomotor retardation, increased vulnerability, a propensity to lacrimal reactions. Gender analysis of suicidal behavior was carried out. It has been revealed that suicidal thoughts and fantasies were more common in women; decisions, intentions and attempts were more common in men. Males used more traumatic suicide means, and females used more gentle suicide means. Suicidal behavior was analized. It has been shown that true suicidal behavior was more common in men, and affective, demonstrative types of suicide frequent were more common in women.
Study of motivation of appeals of patients with partial loss of teeth to dental clinics
Authors: Khrol N.S.
Published: March 2023

A survey of 102 patients in age groups from 18-30 to 65 years and older was carried out. The sex-age structure of the population, which turns to public and private clinics for orthopedic dental care was established. Most often people are 40-49 years old. Women seek help 2 times more often than males. There are serious differences mainly related to the heterogeneous social composition, education of those who applied to the clinic and their level of income. Highly educated patients strive to get into prestigious institutions for orthopedic care. Most patients have an average income. Motivation for appeals is to preserve health.
Research on fabric classification based on graph neural network
Authors: TAO PENG , WENLI CAO , JIA CHEN , XINGHANG LV , ZILI ZHANG , JUNPING LIU , XINRONG HU
Published: March 2023

Fabric classification plays a crucial role in the modern textile industry and fashion market. In the early stage, traditional
neural network methods were adopted to identify fabrics with the drawback of restricted fabric type and poor accuracy.
Combining multi-frame temporality and analysing fabric graph data made from fabric motion features, this paper
proposes a novel hybrid model that introduces the concept of graph networks to classify 30 textile materials in a public
database. We utilize the graph inductive representation learning method (GraphSAGE, Graph Sample and Aggregate)
to extract node embedding features of the fabric. Moreover, bidirectional gated recurrent unit and layer attention
mechanism (BiGRU-attention) are employed in the last layer of aggregation to calculate the score of previous cells.
Intending to further enhance performance, we link the jump connection with adaptive selection aggregation frameworks
to determine the influential region of each node. Our method breaks through the limitation that the original methods can
only classify a few fabrics with great classification results.
The restoration of garment heritages based on digital virtual technology:
A case of the Chinese pale brown lace-encrusted unlined coat
Authors: CHEN HAN , XU HAN , ZHANG YUDIAN , WANG WEIFAN , LU ZHENGYANG
Published: March 2023

Garment heritages are commonly missing evidence of restoration because of their age and complex preservation
environment. Traditional restoration methods rely on the subjective experience of restoration personnel. Its restoration
results are difficult to achieve accuracy and objectivity, exposing precious cultural relics to the risk of irreversible
secondary damage. Taking the Pale Brown Lace-encrusted Unlined Coat as an example, this study puts forward a
method of garment heritages restoration based on digital virtual technology. After fully researching the garment
background information, we used deep learning and virtual twin technology to draw and cut the garment pieces, arrange
and sew the garments, and complete the stained patterns. The results show that our method can restore the original
appearance of the heritages relatively well, providing a new method reference for the inheritance and digital
transmission of traditional garment heritages.
Digital methods in the development of adaptive clothing for people
with disabilities
Authors: IROVAN MARCELA , INDRIE LILIANA , FRUNZE VALENTINA , FLOREA-BURDUJA ELENA , RARU ALIONA
Published: March 2023

Social integration of people with disabilities is a significant issue, therefore effective interventions to provide
improvement of quality of life for people who have some kinds of disabilities are crucial. Specialists from various fields,
including those in the field of clothing design, are working on creating products that meet people with disabilities’ needs.
These products must be ergonomic, comfortable and provide the necessary psychological comfort. The whole process
of designing functional products is very complex, it requires continuous research, using knowledge from various fields
for better development of products.
This paper addresses the topic of developing adaptive clothing for people with multiple sclerosis in the context of social
inclusion and adaptation to new ways of life. All the proposals and ideas are analysed accordingly and different
constructive and technological solutions are proposed to customize and adapt the basic clothing.
Ser do rural-roça-campo: elucidando as origens da identidade em ruralidades
Authors: Dos Santos Mattos Teresa Regina
Published: March 2023

A partir de minha história de vida e considerando o conceito de identidade líquida de Bauman (2003), nas breves linhas deste artigo, proponho-me discutir e discernir sobre as minhas identidades, em especial a rural e urbana, compartilhando a forma peculiar na qual as constitui. Trata-se, portanto, de uma escrita implicada e engajada, reportando os resultados do “mergulho” nas memórias pessoais e familiares. Assim, identifico características das ruralidades a partir dessas memórias, mas sem a pretensão de aprofundá-las. As reflexões deste artigo apresentam-se como uma autoanálise quanto à minha identidade rural-roça-campo provocada por uma inquietação latente que só emergiu após eu alcançar um certo estado de plenitude em minha vida atual.
Um negrogay lançado no Sertão baiano: reflexões sobre a família e o existencialismo
Authors: Souza Antonio José de
Published: March 2023

O presente texto é produto de um projeto de pesquisa que se debruçou sobre a identidade negra e gay na relação intrínseca entre o eu-outro situados em um contexto conflagrado no qual se exige do negrogay tomar consciência ‘de si’. Negrogay, escrito na forma de um único termo, porque é unificado por experiências estigmatizantes que se assemelham. O objetivo, deste estudo, é entender como as construções das identidades negrogays emergiram da história de vida de Rubião Bovary, engendrada no relacionamento e na intimidade da família. Entre outros resultados há a família confrontada em seu papel imprescindível na construção das identidades; o ser-negro negado como parte de uma realidade imaginária criada a partir do desejo de ser um ‘outro’ próximo do ser-branco em autodefesa diante da situação marcada pela estigmatização pública do seu ser-gay.
Abstract: The present text is the product of a research project that focused on the black and gay identity in the intrinsic relationship between the self-other situated in a conflagrated context in which the blackgay is required to become aware 'of himself'. Blackgay, written in the form of a single term, because it is unified by similar stigmatizing experiences. The objective of this study is to understand how the constructions of blackgay identities emerged from Rubião Bovary life story, engendered in the relationship and intimacy of the family. Among other results, there is the family confronted in its essential role in the construction of identities; the self-black being denied as part of an imaginary reality created from the desire to be an 'other' close to the white being in self-white in the face of the situation marked by the public stigmatization of his self-gay.
 
Keywords: Identities blackgays, Family, Existentialism, Auto(biographical) research.
APRESENTAÇÃO
Authors: Melo José Radamés Benevides de , Santos Juracir Silva , Gama Erasto Viana Silva
Published: March 2023

A proposta do Dossiê em Desenvolvimento Sustentável do Semiárido nasceu a partir da articulação entre a coordenação curso de Especialização em Desenvolvimento Sustentável no Semiárido com Ênfase em Recursos Hídricos – DSSERH, promovido pelo Instituto Federal de Educação, Ciência e Tecnologia Baiano – Campus de Senhor do Bonfim. O curso de DSSERH é primeiro curso de pós-graduação do IF Baiano, criado em 2010 a partir de uma proposta de fomento financiada pelo Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) e tem princípios norteadores a capacitação contextualizada e a pesquisa enquanto princípio educativo. O objetivo do DSSERH é qualificar profissionais graduados, possibilitando uma inserção crítica, dialógica e prática que viabilize mudanças de hábitos, valores e atitudes acerca da temática indissociável: homem-água-semiárido, atendendo as demandas do desenvolvimento, sob bases sustentáveis. Assim, o Dossiê em Desenvolvimento sustentável buscou publicizar artigos, desenvolvidos por estudantes e docentes ligados ao DSSERH, de impacto e relevância científica validada pela avaliação duplamente cega realizadas por pares e nesse contexto forma selecionados e publicados cinco artigos.
Electronic Stethoscope Design with IoT (Internet of Things)-based Disease Symptom Detection
Authors: Hamzah Torib , Setioningsih Endang Dian , Sumber Sumber , Ragimova Nazila
Published: March 2023

Auscultation is a technique or method most often used by medical personnel in the initial examination of patients. One way is to use a stethoscope. However, this method has its drawbacks because the diagnosis is carried out subjectively and cannot be relied on with the accuracy to diagnose the symptoms of heart defects. Thus, the purpose of this study is to create an IoT system for electronic stethoscopes with BPM value output and make analog filters to eliminate noise interference which was a major obstacle in previous studies. The contribution to this study is to make it easier for medical users to monitor vital conditions, namely BPM remotely and produce BPM values in real-time. The method used in this study was to use a mic condensor placed on the patient's chest to detect pressure changes that occurred. This change in pressure causes a change in the voltage output value on the condensor mic. Output dari mic condenser masuk dan diproses di rangkaian PSA. Output sinyal dari PSA masuk ke mikrokontroler yang telah diprogram. Hasil yang dipeoleh dari pengukuran mengasilkan nilai error pengukuran nilai BPM dari 5 responden dan diperoleh nilai error yang dihasilkan dari responden 1 diperoleh error sebesar 0.33 BPM, responden 2 diperoleh nilai error sebesar 0,67 BPM, responden 3 memiliki nilai error sebesar 0,5 BPM, responden 4 nilai error sebesar 0,67 dan responden 5 mempunyai nilai error sebesar 0,67 BPM. The results of the statistical test were also obtained P-Value>0.05 which explained that the resulting value did not have a significant difference and could be used for medical purposes. This research can help make it easier for doctors to analyze and diagnose symptoms of heart defects because this system is equipped with the detection of disease symptoms.
Analisis Faktor Penyebab Rendahnya Hasil Belajar Mata Pelajaran PAI-BP Kelas Tinggi di SD Negeri 166/III Cut Mutia
Authors: Rimadhanty Ayuning , Sulaiman Sulaiman
Published: March 2023

This study has the aim of specifically describing what factors influence the low learning outcomes of high-grade PAI-BP at SD Negeri 166/III Cut Mutia Kerinci Jambi. This research is a quantitative research the usage of descriptive approach, with a population of 50 people. The number of samples is 50 students with a population sampling technique. Analysis of the data used, descriptive analysis, prerequisite test analysis, factor analysis and hypothesis testing. The results of the factor analysis showed that there were 3 factors that influenced the low learning outcomes, namely factor 1 (variables of motivation and learning methods), factor 2 (variables of physical health conditions, building conditions and parental upbringing). And factor 3 (interest variable, method and media). The results of the F test were 0.002 <0.05, and F count 5.570 > F table 2.81. So, together the independent variables (X1, X2, X3) have a effect on the dependent variable (Y). The t test on XI gets the result t count 3.969 > t table which is 2.012, a significance of 0.000 <0.05, So variable X1 has a significant effect on variable Y. The t test on X2 gets the result t count 2.129 > t table 2.012 significance 0.039 <0.05 , Then the X2 variable has a significant effect on the Y variable. The t test on X3 gets the result t count 1.566 < t table, namely 2.012 and a significance of 0.124 > 0.05, So the X3 variable has no effect on the Y variable. 26.6% low learning outcomes PAI-BP High grade at SD Negeri 166/III Cut Mutia is influenced by variables X1, X2, X3. And the remaining 73.4% is encouraged by using other variables.
Pengaruh Game Online terhadap Pemerolehan Bahasa Anak Sekolah Dasar
Authors: Asy'ary Muhammad Luqman , Rini Setia , Kusumawati Erna Risfaula
Published: March 2023

The development of information technology is very fast, many benefits are obtained from the development of this technology. One of the benefits of technological developments is the existence of online Game entertainment facilities. This online Game can have an impact on the language acquisition of elementary school children. This study aims to describe the acquisition of language in grade 4 elementary school children aged 9-11 through semantic studies, namely the study of the meaning of a verb, adjective, or noun. The data source comes from the subject to be studied. This research method uses a qualitative approach. Data collection was carried out using five methods, namely observation, observation, notes, interviews, and questionnaires. The results of this study are that online Games can affect the language acquisition of children aged 9-11 years at SDIT Ibnu Mas'ud, Ambarawa District, marked by an increasingly widespread acquisition of words that are absorbed through online Games, such as verbs (victory, booyah, defeat, login, kill, mabar, drift, survival, by one, ngemoti, push), adjectives (perfect, hockey, noob, idiot, bot, asu, op, good at) and nouns (skin, turret, inventory, tournament) which they apply in everyday language
Validitas Media Pembelajaran Interaktif Berbasis Autoplay dalam Mata Pelajaran PAI dan Budi Pekerti untuk Sekolah Dasar
Authors: Erisa Firza , Munir Sirajul , Muchlis Lita Sari , Khairat Annisaul
Published: March 2023

Based on the characteristics of elementary school students who are in line with Pieget's theory of development, children aged 7-11 years are in the concrete operational phase. Grade II students at SDN 04 Balimbing have visual and kinesthetic learning styles. So it requires learning media that is concrete and aligned with the characteristics of students, especially in PAI subjects and Taharah material. The aims of this study were (1) to develop autoplay-based interactive learning media for PAI subjects and Class II SD Taharah subject matter and (2) to determine the validity of autoplay-based interactive learning media. The research method used is research and development using the ADDIE development model. Stages of research using the ADDIE model. The results showed that autoplay-based interactive learning media for PAI subjects and morals in thaharah material were stated to be very valid with an average of 0.847. Validation was carried out by expert lecturers and Islamic education and ethics subject teachers. Based on these results, interactive learning media based on autoplay can be used in learning.
Pengembangan Bahan Ajar Interaktif IPA Materi Sistem Peredaran Kelas V Sekolah Dasar
Authors: Sevilla Clarissa Wury , Halidjah Siti , Ghasya Dyoty Auliya Vilda , Suparjan Suparjan , Pranata Rio
Published: March 2023

This study aims to develop interactive for science subjects related to the Circulatory System Material for Grade V of State Elementary School 30 Pontianak Selatan. This research and development used the 4D model (Four-D) consisting of define, design, develop, and disseminate stages. Quantitative data results from the lift filled in by experts and students. Qualitative data were obtained from suggestions and notes by experts and students. The instruments used were interview guidelines, questionnaires, and documentation. The feasibility level of interactive teaching materials was based on the results of assessments by material experts, design experts, and language experts, while the practicality level of teaching materials was based on the results of student assessments. The feasibility of the material in the aspect of material obtained an average value of 80% and was considered "feasible". The feasibility of the materials in the design aspects obtained an average value of 85% and was considered "feasible". The feasibility of the materials in the language aspects obtained an average value of 100% and was considered "very feasible". The practicality of teaching materials obtained an average value of 85% and was considered "Practical".
A PROSPECTIVE CASE SERIES OF SUBCUTANEOUS ONLAY LAPAROSCOPIC APPROACH (SCOLA) FOR THE CORRECTION OF VENTRAL HERNIA
Authors: Singh Jat Rajkumar , Dubey Rohit , Kumar R.K Vineeth , Ghangoriya Arvind
Published: March 2023

To describe a technique (subcutaneous onlay laparoscopic approach -
SCOLA) for the correction of ventral hernias combined with the
Diastasis of the Rectus Abdominis muscles (DMRA) plication and to
report the initial results of a case series with outcome and followup.
AN OBSERVATIONAL CLINICAL STUDY OF RELEVANCE OF GOODSALL'S RULE IN 50 CASES OF FISTULA IN ANO AT TERTIARY CARE HOSPITAL IN SOUTH GUJARAT
Authors: Chauhan Dharmesh , Bambholia Malhar , Patel Amit , Chaudhari Devendra
Published: March 2023

Despite being one of the oldest reported medical conditions, the management and treatment of stula in ano are still in the evolving phase. The
management of stula-in-ano requires conrmation of the diagnosis, identifying the stulous tract and inner opening. In majority of patients a
single primary stula tract exists and the anatomy can be determined adhering to the principles described by Goodsall. A thorough clinical
examination of the patient is essential in the assessment of stula-in-ano, sometimes helped by imaging such as magnetic resonance imaging and
Fistulogram. Although Goodsall's rule was accepted in the past, as a method to determine the course of the stula, recent studies showed poor
conicting results. This study is an attempt to review the relevance of Goodsall's rule in clinical practice at a tertiary care hospital in South Gujarat.
LEVELS OF SERUM TSH AND ITS IMPLICATIONS IN DEVELOPMENT OF METABOLIC SYNDROME – TIP OF THE ICEBERG: IN YOUNG ADULTS OF GUWAHATI CITY.
Authors: Mazumdar Arijit
Published: March 2023

Thyroid Stimulating Hormone (TSH) is a hormone secreted by the anterior pituitary that plays an important role in regulating the function of the
thyroid gland. Levels of TSH in the blood - is a reliable index of the functional status of the thyroid gland. At present, TSH levels in serum are
estimated by microparticle enzyme immuno assays (MEIA), which are very sensitive. In the current study, serum TSH levels were measured in 100
clinically euthyroid subjects, consisting of 50 males and 50 females. The study found that 12% of the subjects (5 males and 7 females) had TSH
values above the normal, the normal range of the TSH assay being 0.35-4.50 m IU/ml. This nding is signicant in light of the recent focus on
subclinical hypothyroidism being in limelight, particularly the risk of development of overt thyroid dysfunction in persons with high normal values
of serum TSH. Furthermore, such kind of studies in general population among young population was done rarely previously, as a reection of their
serum TSH levels in this part of the India who are considered euthyroid till the time they were tested. Moreover, detection of subclinical or overt
hypothyroid state helps in the preventive aspects as well as to nd out other parameters of metabolic syndrome- which is considered now as just the
tip of the iceberg. In the study, serum TSH levels were measured in 100 eut Materials and methods: hyroid subjects (50 males and 50 females) by
microparticle enzyme immune assay. After analyzing the values of TSH i Results: t was detected that 12% of the subjects (5 males and 7 females)
had TSH levels >4.50 m IU/ml (Upper limit of the normal range). This nding is Conclusion: signicant in light of the recent focus on subclinical
hypothyroidism being particularly at the risk of development of overt thyroid dysfunction in young age leading to a gamut of metabolic disorders
and mortality & morbidity occuring among such populace at a young age Further, it is of importance that such type of lifestyle modiable disorders
can be prevented or reverted to normal if detected early.
A USUAL DISEASE WITH UNUSUAL FINDING – DCIS WITH HEAVY NODAL BURDEN
Authors: Arshad Tahreem , Khan Mohsin , Siddqui Bushra , H Faridi Shahbaz
Published: March 2023

Ductal carcinoma in situ (DCIS) is dened as proliferating malignant ductal cells, limited to the ducts only without any evidence of invasion. The
incidence of axillary lymph node metastasis in pure ductal carcinoma is <1%. Here we describe a case report of DCIS in a 55yr old female, who
presented with a ulcerative lesion in her left breast. Biopsy from the site showed DCIS but surprisingly histopathological report of her mastectomy
specimen showed DCIS with multiple axillary lymph nodes metastasis.
ROLE OF DIFFUSION WEIGHTED IMAGING AND ADC VALUES IN CHARACTERISING BREAST LESIONS ON MR MAMMOGRAPHY
Authors: Surolia Pragya , Kumar Sharma Pawan , Kumawat Jitendra
Published: March 2023

Background- Dynamic contrast enhanced MRI (DCE MR) is an important imaging modality to detect and evaluate the breast lesions with high
sensitivity. Aim of study was to characterize breast lesions detect Objective- ed on MR mammography by diffusion weighted imaging and quantify
ADC values to differentiate benign and malignant mass and non mass lesions. Methods- This prospective study was performed in thirty female
patients on 1.5T GE Healthcare HDXT MRI machine. Thirty three breast lesions were included in this study. Final diagnosis was correlated with
histopathological diagnosis. Out of total thirty three lesions, mean ADC value Results- of malignant lesions was 1.01 ± 0.24 x 10-3mm2/sec and for
benign lesions was 1.48 ± 0.29 x 10-3 mm2/sec. The calculated ADC cut off value of 1.22x 10-3 mm2/sec gave a sensitivity of 86.96% and
specicity of 90% to differentiate malignant and benign breast lesions. As a Conclusion- conclusion Diffusion weighted imaging and quantitative
analysis with ADC values can be used with conventional DCE MR to differentiate benign and malignant breast lesions with high sensitivity and
specicity
PHOTOBIOMODULATION IN DENTISTRY: A REVIEW OF THE LITERATURE
Authors: Shetty Shreema , T. P Najla , Narayan R Nivek
Published: March 2023

Photobiomodulation therapy (PBMT), is the ability to modulate cell growth, survival, and differentiation processes of cells using optimal amount
of energy ,not causing phototoxicity . It includes a wide range of electromagnetic wavelengths such as broadband lights, LEDs, and lasers that may
have both photo stimulation and photo inhibitory effects on the target tissues, each of which can be used in therapeutic applications. Some of the
benets of using PBMTin dentistry include reducing dentin sensitivity to tactile and thermal stimulations, improving dentin formation from dental
pulp, reducing inammation of oral mucosa, accelerating bone formation, reducing pain after all types of dental treatments, and improving wound
healing processes. In this review of literature, we emphasize that PBMT itself or as an adjunct can have a crucial role in decreasing postoperative
dental pain, increasing depth of anesthesia during cavity preparation, decreasing tooth hypersensitivity, reducing inammation of the tissues, and
healing of denture stomatiti
Acción social desde la diversidad familiar en el proceso de paz en el marco educativo en san vicente del Caguán, Colombia
Authors: Virguez Rodriguez Ronald Ferney , López Cardona Diego
Published: March 2023

El presente artículo tiene como propósito exponer los avances de un trabajo investigativo que busca comprender las acciones sociales direccionadas desde el ámbito escolar para el beneficio de los estudiantes de dos instituciones educativas del Municipio de San Vicente del Caguán. Para su sustento teórico, se abordarán categorías de análisis como las acciones sociales, la diversidad familiar y el contexto social que caracteriza a la región; el trabajo de campo se desarrollará desde un diseño cualitativo con enfoque hermenéutico, para facilitar la comprensión de la realidad social a estudiar; como posibles resultados del estudio se espera comprender las acciones sociales que benefician a los estudiantes y vislumbrar si las políticas establecidas para lograr el acuerdo de paz en San Vicente del Caguán, representaron un avance social para la comunidad educativa, o si de alguna manera, solo alivianaron parte del problema de violencia presente en la región, teniendo en cuenta que las condiciones de esta comunidad no son homogéneas a las del resto del país.
تمويل المرجعية الدينية المالي لثورة العشرين 1920 م - دراسة تاريخية
Authors: الحكيم علاء الدين
Published: March 2023

على مدى عشرات القرون احتفظت المرجعية الدينية بطابعها الخاص الذي اختطه لها ائمة اهل البيت عليهم السلام وهو سبر اغوار العلوم والمعارف ورفد عقل الامة بكل ما يستحدث من مسائل نتيجة لتطورات العصر عن طريق فتح باب الاجتهاد ولكنها في الوقت نفسه تراقب كل التطورات السياسية التي تعصف بالأمة الاسلامية .

تعرض العراق للغزو البريطاني عام (1914م) فكانت فتوى الجهاد الاولى , ولعدم استجابة المحتلين لمطالب الشعب جاءت الفتوى الثانية وعلى ضوء هذه الفتوى قادت المرجعية الثورة ضد البريطانيين على مدى خمسة اشهر وامدتها بكل مستلزمات النصر .

ضم الموضوع مبحثين واربعة مطالب , اولهما : مصادر تمويل المرجعية للثورة عن طريق خزانتها المالية والضرائب التي كانت تستوفيها من المدن المحررة , والمبحث الثاني : وسائل تمويل المرجعية وهي الفتوى والحقوق الشرعية .
أصحاب رسول الله (ص) من الجن وفق ما جاء بكتاب هواتف الجن لأبن أبي الدنيا (ت281هـ)
Authors: حسين احمد
Published: March 2023

أن مما لاشك فيه أن النبي محمد صلى الله عليه وآله وسلم بُعث ألى الناس كافه فضلاً عن الجن على اعتبار أن الوضيفه الأساسيه للجن والأنس أنما هي عبادة الله سبحانه وتعالى وتوحيده بدليل قوله تعالى ﴿ وَمَا خَلَقْتُ الْجِنَّ وَالْإِنسَ إِلَّا لِيَعْبُدُونِ﴾ ، ورغم أن العنوان غريب بعض الشيء ولكني سعيت لجرد صحابة رسول الله (ص) من الجن وبيان صحبتهم التي وردت في كتاب هواتف الجن لأبن أبي الدنيا (ت281هـ) وقد سعيت لأن أثبت أولاً لوجود الجن في الثقافه الأسلاميه من خلال النص القرآني الكريم وما ورد على لسان النبي الأكرم صلى الله عليه وآله وسلم عنهم، ثم لأذهب ألى ذكر صحبتهم له(صلوات الله وسلامه عليه).

الكلمات المفتاحيه: رسول الله ﷺ ،الصحابه،الجن،أبن ابي الدنيا،هواتف الجن
المراحل المورفولوجية للنقل الحضري في مدينة الكوت
Authors: علي ماهر , عنوز احمد
Published: March 2023

لقد شهد العالم نمواً عمرانياً هائلاً لعب دوراً مهماً في توسع المناطق العمرانية فيه ، مصحوباً بالتوسع الهائل للنقل الحضري ، بسبب انجذاب سكان مدينة الكوت نحو الضواحي والمناطق الحضرية ، واتسع نطاق المدينة وازداده عددها. وقد ازدادت بأشكال مختلفة تجاه هذه المدينة وتمثلت اتجاهات مختلفة للتدفق الداخلي والهجرة. نتيجة التأثيرات الاجتماعية والاقتصادية والثقافية والسياسية ، بما في ذلك حركة التقدم العلمي والتكنولوجي ، ولأن النقل الحضري لا يزال ينتج العديد من المشاكل المختلفة  والتي تؤثر على مختلف جوانب الحياة ، وتعزى مشاكل النقل الحضري إلى أسباب مختلفة مثل الازدحامات ونقص الشوارع وفي هذا الصدد ، أشار ميرديل إلى أن مجتمعات العالم الثالث لا تعاني فقط من مشاكل اجتماعية أو اقتصادية أو سياسية ، ولكنها تعاني أيضًا من مشاكل معقدة في النقل الحضري تؤثر على جميع جوانب الحياة. مع هذه الحركة من مجتمع إلى آخر وحتى داخل نفس المجتمع ، فإن ، فبعض المدن تكاد تختنق بسبب الاكتظاظ وسوء الإدارة والتنظيم والحركة في النقل الحضري
دلالة الألفاظ بين اللّغة والعُرف والشرع في أصول الفقه عند الشيخ الطوسي
Authors: كاظم حياة , الجمالي حيدر
Published: March 2023

أهتم علماء اللّغة ,والأصول بدلالة الألفاظ وما وُضعت له , وتأرجحها ما بين حقيقة اللّغة والعُرف والشرع وانتقالها من موضعٍ إلى آخر, فمنها ما كان حقيقةً لغوية نحو : الأسماء والألقاب ولعل هذا ما أُطلق عليه الدلالة الوضعية , ومنها ما اختص به العُرف دون غيره , فكانت حقيقةً عُرفية  نحو : الدابة والغائط , ومنها ما كانت  حقيقةً  شرعية  نحو :الصلاة , والزكاة , وهذا ما يُطلق عليه دلالة الاستعمال .

وقد تحَّدث الشيخ الطوسي عن هذه الألفاظ أو كمّا سمَّاها الأسماء في اللّغة والعُرف والشرع  وخصَّصت الباحثةُ هذا الَبْحَثِ للحديث عنها  وجعلته على ثلاثة مطالبٍ :

تعرَّضت في المطلبِ الأول:  لحقيقة الألفاظ في اللّغة أي  الحقيقة اللّغوية

وفي المطلبِ  الثاني : لحقيقة الألفاظ في العُرف أي الحقيقة  العُرفية

وفي المطلبِ الثالث: لحقيقة الألفاظ في الشرع أي  الحقيقة الشرعية , مع ذكر التطبيقات 0
الأنطولوجيا عند كريستيان فولف
Authors: الخطيب محمد
Published: March 2023

يعد الفيلسوف الألماني كريستيان فولف ممثلاً بارزاً لفلسفة التنوير في ألمانيا في القرن الثامن عشر ، وحظيت مؤلفاه ذات الطابع التعليمي بشهرة واسعة ، وكان لها أثرها على المفكرين في عصره وما تلاه من مدد زمنية ، ولذلك نجد لها أثراً واضحاً عند إيمانويل كانط ، كما أثر في فلسفة فريدريك هيغل ، وعلى الرغم من ذلك عد فولف عند أغلب الباحثين بالمتابع لفلسفة لايبنتز ، وأنه مفتقر للأصالة الفكرية ، والذي إتضح من خلال البحث أنه صحيح في الأطار العام ، وليس بشكل مطلق ، إذ كانت لفولف مسائل عارض فيها فلسفة لايبنتز ، ومنها رفضه المذهب الواحدي ( المونادات ) ، كذلك رفضه للمنطق الرياضي الذي دعا إليه لايبنتز ، وذهب إلى أن المنهج الأمثل للفلسفة هو المنهج الإستنباطي .
المنهجية الفقهية للسيد علي الطباطبائي في كتابه رياض المسائل
Authors: الطفيلي صادق , الحمداني عمار
Published: March 2023

عند الكلام عن خلاصة نهائية للمنهجية التي سار عليها السيد علي الطباطبائي في كتاب الموسوم رياض المسائل نجد انه قد وظف في عملية استنباط الاحكام الشرعية جميع الأدلة الاربعة (القرآن والسنة والأجماع والعقل) كما أستعمل القواعد الأصولية والفقهية والرجالية في استنباطه  للحكم الشرعي. كما برزت لدينا في سمته المنهجية التي عُرف بها بين الفقهاء، وهي أنه كان كثير الاحتياط فيما يطرحه من موقف شرعي، أو يتبناه من رأي فقهي. بالإضافة الى ما تقدم نجد أن السيد الطباطبائي قد وظف بعض العلوم في استنباطه للحكم الشرعي, كما في تعيين اتجاه القبلة بواسطة  قوانين الهيئة وهي التسمية القديمة لعلم الفلك. ولعل من بين أهم سمات منهجه الفقهي يبرز لدينا اعتماده على بعض المصادر الفقهية والتفسيرية التي هي محل خلاف بين علماء الشيعة، فقد كان صاحب الرياض يعتمد على كتاب فقه الرضا المنسوب الى الامام الرضا المنسوب للأمام الرضا(عليه السلام) كما اعتمد في موارد تفسير الآيات على تفسير الامام العسكري المنسوب للأمام الحسن العسكري(عليه السلام). وبناءً على هذه المرتكزات في منهجية كتاب الرياض بدا الكتاب متميزاً في كونه على نسق واحد من حيث سعة الطرح وعمق الاستدلال في العبادات والمعاملات على حد سواء. مع كثرة المصادر الفقيهة التي اعتمدها. وبالنتيجة كان من الواضح بأن الكتاب يقوم على الاستدلال وليس مجرد نقل الاقوال الفقهية.