bluuebunny/crossref_metadata_2025 huggingface dataset:
Seroprevalence and Risk Factors Associated with Leptospirosis in High-Risk Occupational Groups in the State of Gujarat as Determined by IgM ELISA and MAT Test: A Cross-Sectional Study
Authors: Mevada Yogendra , Vinod Kumar Kirubakaran , Balamurgan Vinayagamurthy , Chavhan Snehal , Kumar Jitendra , Palkhade Rajendra
Published: June 2024

Background:

Leptospirosis is a reemerging zoonosis affecting humans and animals worldwide in tropical and subtropical countries. The study was conducted to estimate the seroprevalence of leptospirosis in high-risk occupational groups (cattle farm workers, poultry farm workers, and slaughterhouse workers) in the state of Gujarat and to determine related risk factors for leptospirosis.

Methods:

Using an interview-guided questionnaire, a cross-sectional study was conducted involving 123 people in high-risk occupational groups (namely, cattle farm workers, poultry farm workers, and slaughterhouse workers) from five districts of the state of Gujarat, India. The participants’ serum samples were screened for antileptospiral antibodies by using Immunoglobulin G (IgG) and Immunoglobulin M (IgM) enzyme-linked immunosorbent assays (ELISAs) followed by a microscopic agglutination test (MAT). The Chi-square (χ2) test and odds ratio were calculated using IBM SPSS Statistics for Windows, version 22 (IBM Corp., Armonk, N.Y., USA) to ascertain the associated risk factors.

Results:

Regarding demographic information, this study included 104 men and 19 women in high-risk occupational groups. The overall seroprevalence of antileptospiral antibodies in these high-risk workers was 46.3%. The seroprevalence was the highest among poultry farm workers (56.6%), followed by cattle farm workers (54.5%) and slaughterhouse workers (25.6%). The MAT in combination with IgM is adequate for the serological diagnosis of leptospirosis, but we have also employed IgG ELISA to understand the chronic infection in these high-risk occupational groups as exposure was both past and present. Tests were conducted for antibodies against various Leptospira serovars in the major serogroups; frequent serovars included Hurstbridge, Panama, Javanica, Tarassovi, Copenhageni, Pomona, and Weaveri, among others. The significant (P < 0.05) risk factors associated with leptospirosis in these high-risk occupations reported to be living in field areas, the presence of livestock in the neighborhood, working in slaughterhouses, drinking water from natural water resources, contact with animals such as dogs or livestock, and wounds during occupational practice.

Conclusion:

Considering the high seroprevalence of leptospirosis, high-risk occupational groups should be regularly screened for potential development of the fatal disease. Hurstbridge was found to be the most prevalent serovar in the studied population, followed by Panama, Javanica, and Tarassovi.
Plasma Cell Infiltrate in Liver Allograft Biopsy: Clinical and Histological Implications
Authors: Agrawal Neha , Rastogi Archana , Bihari Chhagan , Choudhury Ashok , Pamecha Viniyendra
Published: June 2024

Introduction:

The relevance of plasma cells in the allograft liver is of utmost importance and objective assessment of these infiltrates and correlation with other ancillary findings needs to be evaluated.

Materials and Methods:

Three hundred and sixty-eight graft liver biopsies received in the department from 2012 to 2022 and 115 allograft liver biopsies with histopathological diagnosis of rejection were selected. Based on plasma cells percentage in the portal tracts, the biopsies were divided into three groups: Group 1 showing not more than an occasional plasma cell, Group 2 showing <10% plasma cells, and Group 3 showing >10% plasma cells. Rejection activity index (RAI), portal/lobular inflammation, interface activity, subendothelial inflammation (portal and central vein), duct damage/loss, presence of cholestasis, apoptosis, perivenulitis, necrosis, rosette along with serial liver function tests (LFTs), and patient status at 1 year of follow-up were recorded and compared between the groups.

Results:

Plasma cell infiltrates were observed in 52.6% of the specimens, with the mean percentage of plasma cells in the infiltrates being 4.9. Increased plasma cell infiltrates were associated with higher RAI scores, marked duct damage, marked portal and central vein endotheliitis, marked portal inflammation, and presence of interface activity. Higher levels of transaminitis were recorded at the time of biopsy, but no significant association was observed in the fall of serial LFTs over a 2-week period with the presence of plasma cells.

Conclusion:

Identifying plasma cell infiltrates in liver allografts can serve as a clue toward increased severity of rejection in liver allograft biopsies. Further studies with emphasis on correlation with the clinical outcome and response to treatment are needed to validate its utility as an objective tool.
Urinary Mitochondrial DNA Induces an Inflammatory Response in Peripheral Blood Mononuclear Cells
Authors: Yadav Brijesh , Prasad Narayan , Kushwaha Ravi Shanker , Singh Ankita , Yadav Deependra , Bhadauria Dharmendra Singh , Kaul Anupma
Published: June 2024

Background:

Mitochondria are semiautonomous cell organelles having its own nucleic acid. Mitochondrial DNA (Mt-DNA) remain in hypomethylated (CpG) state and impose an immunogenic response by binding to the toll-like receptor (TLR-9) through the NF-kB pathway. Innate immune cells recognize the hypomethylated pattern of mt-DNA and quickly trigger the innate immune response. The immunomodulatory effects of urinary mt-DNA derived from renal transplant recipients with COVID-19-associated acute kidney injury (AKI) have not been studied.

Materials and Methods:

Healthy donor peripheral blood mononuclear cell (PBMC) was cultured with the urinary Mt-DNA derived from the renal transplant recipients, who previously developed SARS-CoV-2 infection associated AKI. Cell activation was measured by the flow cytometry. In cell pellets, interleukin IL-6, IL-10, and Myd88, TLR-9 mRNA transcript expression was measured by the reverse transcription polymerase chain reaction. The IL-6 and IL-10 cytokine levels were measured by the enzyme-linked immunosorbent assay in culture supernatants.

Results:

The urinary mitochondrial DNA (umt-DNA) significantly induces the activation of > 75% of PBMCs. The m-RNA transcript expression of the inflammatory gene in control versus umt-DNA treated PBMCs was for IL-6 (0.99 ± 0.05 vs. 2.18 ± 1.15 au; P = 0.004), MYD88 was (1.00 ± 0.05 vs. 1.55 ± 0.31; P < 0.001), TLR-9 (1.00 ± 0.05 vs. 3.33 ± 1.37 au; P < 0.001) was upregulated, and the IL-10 (1.00 ± 0.13 vs. −1.73 ± 0.58; P < 0.001) level was downregulated. However, in PBMC culture supernatants, IL-6 level in control versus umt-DNA-treated groups were (37.50 ± 13.79 vs. 186.9 ± 15.50 pg/mL; P < 0.001), which was significantly higher in umt-DNA-treated groups and the IL-10 (8.80 ± 2.16 vs. 7.60 ± 3.12 pg/mL; P = 0.32) level was similar between the control- and umt-DNA-treated groups.

Conclusions:

Urinary Mt-DNA significantly induces the inflammatory cytokine IL-6 secretion from the PBMCs through the Myd88-dependent pathway.
Identification of Key Genes Associated with Polycystic Ovarian Syndrome and Endometrial and Ovarian Cancer through Bioinformatics
Authors: Raulo Karishma , Qazi Sahar
Published: June 2024

ABSTRACT

Background:

Polycystic ovary syndrome (PCOS), a common endocrine disorder, is linked to increased risks of endometrial cancer (EC) and ovarian cancer (OC). Our study utilises bioinformatics analysis to identify shared gene signatures and elucidate biological processes between EC and OC and PCOS.

Aim:

The objective of this research is to unveil the common molecular landscape shared by PCOS and EC and OC.

Settings and Design:

An observational computational bioinformatics analysis.

Materials and Methods:

Gene expression profiles for PCOS (GSE199225), EC (GSE215413) and OC (GSE174670) were obtained from the Gene Expression Omnibus database. Hub genes were identified through functional enrichment analysis and protein–protein interaction. Drug identification analyses were employed to find drugs targeting the hub genes.

Results:

Key hub genes linking PCOS and EC includes RECQL4, RAD54L, ATR, CHTF18, WDHD1, CDT1, PLK1, PKMYT1, RAD18 and RPL3; for PCOS and OC, they include HMOX1, TXNRD1, NQO1, GCLC, GSTP1, PRDX1, SOD1, GPX3, BOP1 and BYSL. Gene Ontology analysis revealed DNA metabolic process in PCOS and EC, while in PCOS and OC, it identified the removal of superoxide radicals. Kyoto Encyclopaedia of Genes and Genomes pathway analysis highlighted cell cycle in PCOS and EC and hepatocellular carcinoma in PCOS and OC. Potential drugs for PCOS and EC include quercetin, calcitriol and testosterone; for PCOS and OC, eugenol and 1-chloro-2,4-dinitrobenzene are identified.

Conclusion:

These findings offer insights into potential therapeutic targets and pathways linking PCOS with EC and OC, enhancing our understanding of the molecular mechanisms involved in these associations.
Assessment of Malaria Pharmacotherapeutic Outcomes in Children under 12 Years of Age among Three Health-care Facilities, Bayelsa, Nigeria
Authors: Charles Ronari O. , Bunu Samuel J. , Charles Oyintari , Orumwense Daniel O.
Published: June 2024

Background:

Malaria is Nigeria’s biggest public health problem, accounting for around 30% of all fatalities among children under 5 years, 25% of infant deaths, and 11% of maternal mortality.

Aims and Objectives:

The study aimed to identify the outcomes of malaria therapy in children under 12 who were admitted and managed at three health facilities in Bayelsa State, Nigeria, and if the treatment pattern adhered to standard guidelines.

Materials and Methods:

A detailed retrospective survey was designed, and a data collection instrument was utilized to obtain clinical, medical, and medication histories for children from the selected health facilities between January 2019 and June 2020. The survey collected data from 1312 children. The data were analyzed using a Chi-square test in SPSS version 23.0 and Microsoft Excel 2013.

Results:

From the data obtained, only 37.73% of the 1312 participants underwent a malaria parasite (MP) test. The most common diagnosis made at the Primary HealthCare Center (PHC) was acute/uncomplicated malaria (43.0%), followed by diarrhea (21.3%), and gastroenteritis (GET) with upper respiratory tract infection (15.7%). The most common diagnoses for Secondary HealthCare Center (SEC) and Federal/Tertiary HealthCare Center (FHI) were malaria with GET (22.5%) and severe malaria with meningitis (18.1%). The majority of patients were effectively handled and discharged, FHI (73.0%), SEC (91.1%), and PHC (94.0%). Other notable outcomes included patients’ task capacity and a temperature decreased to normal (TDN).

Conclusion:

There was a significant correlation between demographic data and treatment outcomes (P < 0.05). Although the three health facilities provided competent patient management along with appropriate prescription trends for malaria and comorbidities, there was a low proportion of patients who received an MP test, particularly at the FHI.
Prevalence of Xerostomia and Hyposalivation Among Individuals Attending Oral Cancer Screening in Thailand: A Cross-Sectional Study
Authors: Ekkert Sutthipoach , Deeiam Krongkan , Klongnoi Boworn , Sresumatchai Vanvisa , Pimolbutr Kununya , Khovidhunkit Siribang-on Piboonniyom
Published: June 2024

Abstract

Aim:

It has been speculated that the prevalence of xerostomia and hyposalivation might be higher among individuals attending oral cancer screening than among members of the general population. Therefore, this study investigated the prevalence of these conditions and their associated factors among individuals taking part in oral cancer screening and residing in the northeastern provinces of Thailand.

Materials and Methods:

This cross-sectional study recruited convenient individuals aged ≥40 years with at least one oral cancer risk factor. In total, 561 participants were included. Demographic characteristics and relevant oral cancer risk factors were recorded. A questionnaire comprising five items was used to assess xerostomia. Participants were then categorized into two groups based on the absence or presence of xerostomia. Subsequently, the stimulated salivary flow rate was assessed using the spitting technique to identify hyposalivation. Participants were then separated into two groups depending on the absence or presence of hyposalivation. Univariate and multivariate logistic regression analyses were then performed to identify factors associated with xerostomia or hyposalivation.

Results:

The mean age of participants was 65.62 ± 9.70 years, and approximately 60% of participants were post-menopausal women. The prevalence of xerostomia was 43.85%, and the prevalence of hyposalivation was 61.50%. It was revealed that age ≥65 years (odds ratio [OR] = 1.57, P = 0.02) and burning sensation in the mouth (OR = 5.36, P < 0.001) were strongly associated with xerostomia. Female participants were more likely to exhibit hyposalivation (OR = 2.38, P = 0.001). Oral cancer risk factors were not associated with xerostomia or hyposalivation.

Conclusions:

In this study, age ≥65 years and burning sensation were identified as risk factors for xerostomia, whereas female sex was a risk factor for hyposalivation. Dentists should be aware of both conditions. Various interventions to alleviate dry mouth symptoms might be useful for individuals with these risk factors.
A Bibliometric Analysis of the Top 100 Cited Articles in Regenerative Periodontics Surgery: Insights and Trends
Authors: Alqahtani Hussam M. , Haq Ikram UI. , Alrubayan Mohammed , Alammari Faisal , Alotaibi Fahad , Al Khammash Abdalrahman
Published: June 2024

Abstract

Aim:

The aim of this study was to identify and appraise the bibliometric properties of top 100 most-cited articles on regenerative periodontics surgery (RPS).

Materials and Methods:

The bibliometric research technique was conducted using a dataset comprising the 100 highly cited articles obtained from Elsevier’s Scopus database on RPS. Information regarding the growth of articles by year, number of citations, citations per year, study design, study field, modalities, journals, authors, and countries were extracted for each article. Microsoft Excel (v.16) was utilized for data evaluation and tabulation. These articles on RPS were published over a span of 45 years, from 1975 to 2019, with citation metrics ranging from 144 to 820. Out of the 422 participating authors, 82% contributed to a single article.

Results:

The 100 most cited articles on RPS were published in 45 years from 1975 to 2019 and number of citations ranged from 144 to 820. Out of the 422 participating authors, 82% contributed in a single article.. The study design with the highest number of cited articles was laboratory/animal studies. Others/not specified was the preferred modality, followed by infrabony modality. The Journal of Periodontology published about one-fourth of the articles, with W. V. Giannobile emerging as the most productive author. Among the 100 most-cited articles on RPS, authors from 25 different countries contributed, with the United States producing half of the articles (n = 51). Bibliometric investigation revealed that the most cited papers published before 2000 had higher citation counts due to their longer period of exposure. The ratio of authors per article increased after the year 2000.

Conclusions:

Infrabony emerges as a trending topic in RPS, with laboratory/animal studies, clinical trials, and literature reviews being the most frequently employed study designs.
A protocol of a systematic review and meta-analysis on the prevalence of mental health disorders among older adults and synthesis of community-based interventions among them in low- and middle-income countries
Authors: Das Devi , Khasnobis Madhurima , Dutta Susmita , Hoda Suchismita , Pal Arkaprovo , Sundström Christopher , Kraepelien Martin , Kandasamy Arun , Mehta Swati , Dahiya Neha , Saha Indranil , Saha Asim , Chakrabarti Amit
Published: June 2024

Background:

Older adults of low- and middle-income countries (LMICs) have a higher prevalence of mental health disorders compared to high-income countries, which can be attributed to a combination of social factors (such as isolation and loss of spouse), declining physical well-being, and the cumulative impact of life stressors, all of which contribute to an increased vulnerability in mental health.

Objectives:

The objective of this study was to determine the pooled prevalence of mental health disorders among older adults in LMICs and to identify community-based mental health intervention measures to tackle mental health problems in LMICs.

Methods:

Articles will be retrieved from databases such as PubMed, Scopus, and Cochrane Central using MeSH terms, keywords, and text words for each concept. Preprint search servers (MedRx, Cogprints, IndiaRxiv, medRxiv, and SSRN) will also be accessed. Data analysis will be conducted as per guidelines provided in the Handbook of Cochrane Systematic Review. RevMan version 5.4 software will be used for pooled analysis. Expected outcome: This systematic review will be able to identify the pooled prevalence of mental health among older adults and will also identify the evidence-based mental health intervention measures in community settings among older adults of LMICs.
Enhancing Healthcare Access: Drone-based Delivery of Medicines and Vaccines in hard-to-Reach Terrains of Northeastern India
Authors: Aggarwal Sumit , Balaji Sivarman , Gupta Prakamya , Mahajan Nupur , Nigam Kuldeep , Singh Khangembam Jitenkumar , Bhargava Balram , Panda Samiran
Published: June 2024

Background:

Ensuring efficient healthcare access in a geographically diverse country like India poses significant challenges, particularly in challenging terrains. Conventional transportation methods often encounter difficulties due to inadequate infrastructure and adverse climatic conditions, resulting in delays in medical supplies. This study aimed to assess the viability of drones for transporting various types of medical supplies across diverse geographical landscapes, also evaluating their impact on transportation time, covered distance, weight carrying capacities and safety of medical supplies.

Materials and Methods:

The study spanned 4 months across 19 healthcare centres across Manipur and Nagaland. Different types of drones were used for the transportation of vaccines, medications and surgical items across these centres covering terrains such as flatlands, valleys, foothills, islands and hills.

Results:

Drones were able to successfully transport the medical supplies maintaining the essential temperatures and integrity of the samples. Further, drone-based supplies significantly reduce the delivery time compared to conventional road-based delivery mechanisms.

Conclusion:

The present study demonstrates the potential application of drones for the delivery of healthcare supplies in remote areas. Despite the logistical challenges, drones offer a time-efficient alternative for medical supply delivery. However, there is a need for further research and logistical infrastructure development in the current field.
Comparison of Calibration Drift in Transcutaneous Carbon Dioxide Monitoring Devices for Overnight Level 4 Sleep Study in Hong Kong Children
Authors: Ng Selina Ka-wai , Chan Eric Yat-tung , Leung Shuk-yu
Published: June 2024

Background:

Level 4 sleep study with transcutaneous carbon dioxide (TcCO2) monitoring is a simple, non-invasive method to investigate sleep-related hypoventilation. However, calibration drift in the TcCO2 device weakens its reliability.

Materials and Methods:

We conducted a retrospective study of 61 patients from <1 to 20 years of age in our paediatric unit, who were assigned one of the two models of TcCO2 machines (SenTec Digital Monitoring System and Tina Radiometer Copenhagen TCM4 Transcutaneous Blood Gas Monitor) for performing the Level 4 sleep study, using capillary blood gas carbon dioxide (pCO2) level at the first and ninth hours as a reference.

Results:

For the 9-h sleep study, there was no change in the attachment site, membrane, or sensor. The TcCO2–pCO2 difference at the ninth hour in the former model was 0.03 ± 0.61 kPa (0.26 ± 4.59 mm Hg), which was favourable in comparison to the latter (–0.45 ± 1.25 kPa or –3.38 ± 9.38 mm Hg), with P = 0.014; the TcCO2–pCO2 difference between monitors A and B at the ninth hour compared to the first hour did not differ substantially from the former (P = 0.160), but a statistically significant difference was noted in the latter model (P = 0.037). Both findings indicated calibration drift and hence less accurate TcCO2 readings in the latter model.

Conclusion:

In overnight extended use, calibration drift might affect the diagnosis and management of sleep-related hypoventilation.
Evaluation of a Student Pharmacist-Driven Fall-Prevention Program for Older People
Authors: Lohmann Ashley M. , Coad Leah M , Barton Camryn E. , Vulcano Danielle G. , Li Junan , Emptage Ruth E.
Published: June 2024

There is limited research on the impact of fall prevention education for older community-living people led by student pharmacists, which includes a medication review to identify Fall Risk-Increasing Drugs (FRIDs). Study objectives were to first assess the knowledge and behavioral intentions
of older people after attending a student pharmacist-led fall-prevention program (FPP) and secondly to quantify the number of FRIDs identified during a medication review. Between October 2022 and April 2023, four independent-living facilities and two senior centers served as programming locations.
Events began with a fall prevention-focused presentation provided by student pharmacists. Attendees voluntarily filled out surveys to assess their knowledge and behavioral intentions regarding fall prevention. Optional medication reviews were offered. Additional survey questions were asked
of medication review participants. If FRIDs were identified, the individual was provided documentation to share with their prescriber. Fall prevention bingo was offered at select events to review educational content and engage those waiting for a medication review. Eighty-six older people
attended the presentations; 45 people completed medication reviews across six sites. Survey information was available for 65 presentation attendees and 29 medication review participants. After programming, 64 out of 65 participants stated they felt comfortable speaking to their pharmacist
or provider about falls and their medications. Most survey respondents correctly selected which medications increase fall risk. Twenty-two of 29 medication review participants were taking at least one FRID. The FPP described showed positive results through a post-survey evaluation. Participants
demonstrated knowledge of fall hazards including medications and a willingness to discuss falls and FRIDs with health professionals. These factors may lead to concrete interventions to avoid falls and their associated health consequences for older people.
Comparative analysis of bulk and velocity-derived density data in deep wells in the Adriatic Region (Italy)
Authors: Mariucci Maria Teresa , Montone Paola , Balossino Pietro
Published: June 2024

This work is based on a systematic comparison between two datasets related to density data of geological formations crossed in 13 deep wells. The wells are located in the Adriatic area and reach depths of over 5000 meters. The main lithologies involved include sandstones, marls, clays, evaporite, and carbonate rocks. The first dataset concerns density values obtained from the analysis of sonic logs recorded along the wells, by applying the Gardner relation. The second dataset, on the other hand, refers to actually acquired density log measurements. Differences among the values in the two datasets have been calculated. The aim behind this work is to assess the reliability of rock densities estimated using the Gardner equation by comparing them to measurements obtained through density logs, despite many factors influencing the log density. This comparison of the densities obtained from various lithologies and geological formations leads us to draw, in this region, some initial considerations regarding the applicability and accuracy of Gardner formula, usually considered as standard reference, since the density log is generally available only within the reservoir. In the area we analyzed it is observed that the density values estimated from sonic velocities are underestimated for the Plio-Quaternary formations characterized by clayey-sandy lithologies by at least 0.1 g/cm3; whereas, densities of the carbonate sequences are overestimated by the same extent. Noteworthy, the density estimates deviate from the real values especially for gypsum units, overestimating by a factor of approximately 0.3 g/cm3. The results we obtained emphasize differences in density values when using the Gardner formula and suggest the need for taking into account the possible errors in the specific geological context or instead lithologies, such as those explored in this study.
YARGITAY KARARLARI IŞIĞINDA KİRA UYUŞMAZLIKLARI VE KİRA UYUŞMAZLIKLARININ İÇ TAHKİME ELVERİŞLİLİĞİ
Authors: Kasalak Salih Hakan
Published: June 2024

Uygulamada sıkça karşılaşılan kira uyuşmazlıkları; kira bedelinin tespiti, kiracının tahliyesi davası ve kira uyuşmazlıklarından kaynaklı tazminat davasıdır. Kira bedelinin tespiti davası, kiracı veya kiraya veren tarafından açılabilen ve yeni kira yılında kira bedelinin belirlenmesi sağlayan davadır. Tahliye davası ise kanun metninde yer alan dava sebepleriyle sınırlı olacak şekilde kiracının tahliyesini sağlayan davadır. Kira uyuşmazlıklarından kaynaklanan tazminat davası ise kiralananın ayıbı ya da kiracının verdiği maddi ve manevi zararların tazmini amaçlayan alacak davasıdır. Kira uyuşmazlıklarında da taraflarca tahkim yargılamasına başvurulduğu görülmektedir. Tahkim ise tarafların karşılaştığı uyuşmazlıkların devlet yargılaması yerine tarafların anlaşarak yargılamayı hakemlere bırakması ve hakemlerin tahkim yargılaması sonucunda uyuşmazlığı çözmesidir. Tahkim yargılaması kanun gereği iki uyuşmazlık durumunda elverişli olmayacaktır. Bu haller, tarafların iradelerine tabi olmayan uyuşmazlıklarla taşınmazın aynınden kaynaklı uyuşmazlıklardır. Ancak yargı kararları incelendiğinde konut ve çatılı iş yeri kiralarında kira bedelinin tespiti ve tahliye davalarında kamu düzeni kavramı ve zayıfın koruma ilkesi gereğince tahkime uygunluğu sorgulanırken, konut ve çatılı iş yeri kiralarında kira sözleşmesinden kaynaklı alacak davası hakkında ise tarafların iradeleriyle çözümlenebilecek uyuşmazlık olarak görülmesi ağırlıklı görüştür. Ticari nitelikli kiralar yönünden ise tacirlerin basiretli şekilde davranması gerektiği bu sebeple zayıfı koruma ilkesinin uygulama alanı bulmadığı ve tahkime elverişli olduğu düşüncesi yargı kararlarında kabul görmektedir. Bu çalışmada öncelikle kira uyuşmazlıklarının tahkime elverişliliğini etkileyen kavramlar irdelenecektir. Çalışmanın ikinci kısmında konut ve çatılı işyerleri kira uyuşmazlıklarına konu olan dava türleri ve ticari davalar hakkında bilgi verilecek ve kira uyuşmazlıklarının tahkime elverişliliği Yargıtay kararları ışığında ele alınacaktır.
LEAN ACCOUNTING AND ITS IMPACT ON REDUCING PRODUCTION COSTS IN INDUSTRIAL COMPANIES: A FIELD STUDY ON INDUSTRIAL COMPANIES OPERATING IN THE STATE OF KHARTOUM/ SUDAN
Authors: Abdalla Eldoom Adam Adam
Published: June 2024

This study aimed to demonstrate the impact of lean accounting on reducing the cost of production in industrial companies. The analytical descriptive approach has been used in this study and it also tested the basic hypothesis which was the presence of any a statistical impact of lean accounting on reducing production costs. The study has come up with several results, including the presence of an impact of lean accounting on cost reduction. The study recommended several Recommendations, including the need for industrial companies to pay attention to continuous improvement, employees, and the performance linking scheme in order to contribute to reducing costs and pricing, beside competition locally and abroad.
Spiritualitas Solidaritas Feminis dalam Pandangan Yesus dalam Kitab Injil dan Relasinya dengan Pemberdayaan Perempuan di Gereja Toraja
Authors: Darius Darius , Laen Surianti , Melianus Melianus
Published: June 2024

Penelitian ini mengulas spiritualitas solidaritas feminis dalam kitab Injil sebagai refleksi bagi gereja khususnya Gereja Toraja terkait pemberdayaan perempuan dalam pelayanan. Refleksi terkait spiritualitas solidaritas feminis menjadi dasar bagi gereja untuk menjaga keseimbangan antara laki-laki dan perempuan khususnya dalam pelayanan. Penelitian ini hendak menjawab bagaimana keterkaitan antara spiritualitas solidaritas feminis dalam pandangan Yesus dengan pemberdayaan perempuan di Gereja Toraja? Karena itu, tujuan penelitian ini mendeskripsikan keterkaitan spiritualitas solidaritas feminis dalam pandangan Yesus dengan pemberdayaan perempuan di Gereja Toraja.  Metode yang digunakan dalam penelitian ini adalah kualitatif deskriptif. Peneliti mendeskripsikan teks-teks dalam kitab Injil khususnya konsep-konsep spiritualitas solidaritas feminis dalam pandangan Yesus. Analisis teks dengan pendekatan tafsir terkait spiritualitas solidaritas feminis sebagai landasan bagi gereja Toraja khususnya terkait pelibatan perempuan dalam penatalayanan gereja. Selain pendekatan atau analisis biblis di atas, maka dalam penelitian ini juga menggunakan metode wawancara. Proses wawancara ini akan dilakukan untuk mendapat informasi dari informan terkait pemberdayaan perempuan di Gereja Toraja. Pendekatan komparasi ini menunjukkan bahwa ada kesamaan terkait prinsip-prinsip atau spiritualitas solidaritas feminis dalam pandangan Yesus khususnya dalam kitab Injil dengan pemberdayaan perempuan di Gereja Toraja. Penelitian ini menunjukkan bahwa Pertama, pelibatan perempuan dalam pelayanan sebagai pendeta jemaat, diaken, dan penatua sebagai bukti bahwa Gereja Toraja telah menerapkan kesetaraan gender. Kedua, keterlibatan perempuan dalam berbagai bidang pelayan termasuk  dalam struktur kepemimpinan sinodal. Sikap demikian menunjukkan suatu prinsip atau spiritualitas ekualitas dan spiritualitas solidaritas feminis dalam pandangan Yesus telah diterapkan dan masih terus dikembangkan terkait pemberdayaan perempuan Gereja Toraja.
Polinizadores de lo común. Las artes de lo vivo y lo no vivo
Authors: Insúa Lintridis  Lila
Published: June 2024

Un repertorio de materialidades en forma de siete dibujos conforma este proyecto de creación, de nombre Polinizadores de lo común, que da cuenta de la ambigua idea de lo vivo y lo no vivo en las artes. Una escritura-esqueje que parte de esta serie de dibujos. La naturaleza de esta escritura dibujada es movilizar y sostener una serie de preguntas, propias y del común, nacidas del medio que habitamos y de anteriores reflexiones sobre la conservación o memoria de las artes escénicas en sentido expandido. 
En la tarea de rumiar —desde estos presupuestos— nos acompañamos del marco conceptual propuesto por Silvia L. Gil (sobre un horizonte feminista y dónde colocar la esperanza) y de Vinciane Despret (con los modos y maneras de arañas y pulpos). Otros seres no humanos como las mariposas monarca nos llevan a transitar por las dimensiones cosmológicas de la cultura. El trazado de esas rutas migratorias en las artes y sus conexiones entre lo vivo y lo muerto, más allá de una lógica binaria, forman parte entretejida y revuelta de la realidad que habitamos. 
Partiendo del fragmento, la variación, la mutación o el enigma, este texto abraza historias que crean mundos, bucea sus rastros en la escritura con la ayuda y a modiño de una investigación basada en la práctica artística.
FERAL WOOL. Designing with a vibrant matter with care and cosmoecological perspective in times of troubled abundance
Authors: Uğur Yavuz Seçil , Bektaş Merve , Ayala Garcia Camilo
Published: June 2024

Feral Wool is an ongoing research-through-design project that takes place in the South Tyrol region in Italy. It explores the concept of overflowing and overlooked local wool that becomes a troubled abundance due to the global dynamics of the “Capitalocene”. By calling wool "feral” as an entry point, we highlight the abandonment of a precious matter while regenerating narratives of plural cosmo-ecologies. Through design, the project traces invisible and neglected stakeholders to open up space for new alliances to imagine alternative futures of local wool. Our article poses the following questions: What other cosmologies need to be considered to bind interspecies relations and foster care? What other new aesthetics of wool need to be discovered as a “matter of care” and relationality? We address these questions by unfolding research insights into new care practices and processes while also representing a visualisation of wool cosmology which will serve as a basis for multispecies dreaming for wool futures.
VCP-related Multisystem Proteinopathy Presenting with Lobulated Myofibers
Authors: Chae Juhee , Park Sung-Hye , Sung Jung-Joon
Published: June 2024

Valosin-containing protein (VCP)-related multisystem proteinopathy (MSP1) is a rare genetic disorder marked by abnormal protein accumulation. This study presents the case of a 52-year-old woman with MSP1, showing progressive weakness, gait disturbances, and respiratory muscle weakness over five years. The clinical examination revealed diverse presentations, including neurogenic changes in electrophysiologic study, multifocal fatty changes of muscle, and cognitive impairment with a confirmed VCP gene mutation through genetic testing. Notably, we identified lobulated myofibers in the muscle biopsy, an unusual finding in MSP1. This is the first report of lobulated myofibers in MSP1 with multisystem involvement. Identifying unique muscle biopsy results in suspected MSP1 patients through careful neurological examinations and timely genetic testing may help in early diagnosis and appropriate management.
PENGARUH BIAYA PENGIRIMAN DAN ESTIMASI PENGIRIMAN TERHADAP KEPUASAN PELANGGAN PADA PT. LAUTAN BENUA NUSANTARA INDONESIA DI MEDAN
Authors: Manurung Pasquita Patricia , Rangkuti Sahnan , Firah Al
Published: June 2024

This research aims to determine the effect of shipping costs and delivery estimates on customer satisfaction at PT. Lautan Benua Nusantara Indonesia in Medan. The number of samples in this research was 150 customers from a total population. Sample selection uses saturated samples. This research method is a quantitative method. The data collection technique uses primary data and secondary data in the form of a questionnaire using a Likert scale. The results of the t test with a value of tcount < ttable (1.230 < 1.655) mean that shipping costs have no effect on customer satisfaction at PT. Lautan Benua Nusantara Indonesia in Medan. The results of the t test with a value of tcount > ttable (6.108 > 1.655) mean that delivery estimates have a positive and significant effect on customer satisfaction at PT. Lautan Benua Nusantara Indonesia in Medan. The results of the F test with a value of Fcount (20.591) > Ftable (3.060) mean that the variables of shipping costs and delivery estimates have a significant effect on customer satisfaction. The calculation results obtained a coefficient of determination of 0.219 (21.9%). Customer satisfaction is influenced by shipping costs and delivery estimates. Meanwhile, the remaining 78.1% was influenced by other variables not studied. The better the goods delivery process, the greater customer satisfaction will be. The process of arriving goods to customers is not optimal and does not match delivery estimates because the means of transportation used are often damaged. Customer satisfaction is closely related to on-time delivery, safety of goods (goods are not reduced, not damaged, not lost, guarantee compensation). However PT. Lautan Benua Nusantara Indonesia in Medan is not optimal enough in managing timeliness and there is no guarantee of compensation.
Kuagro tradicional
Authors: De Ávila torres Dimas del Rosario
Published: June 2024

Este texto recoge parte de la tesis de doctorado «Ma-kuagro y las estrategias didácticas para su transmisión cultural en San Basilio de Palenque, Colombia», para optar al Grado de Doctora en Cultura y Educación. Método: Investigación de corte etnográfico y diseño soportado en el Método de la Consulta a la Memoria Colectiva con entrevista a 14 palenqueros y palenqueras distribuidos en tres grupos: expertos académicos-investigadores, expertos lideres sociales y comunidad en general.  Resultados: Se presentan relatos de kuagro tradicional mostrando relaciones entre sus momentos de creación; tensiones entre las reglas y el sistema de derecho propio y valores; entre los ritos de guerra y el antagonismo de los kuagros sector arriba y debajo en el pueblo que muestra elementos de relaciones y transformaciones en la actualidad. Conclusiones: Ma- kuagro se sitúa como el eje de las manifestaciones culturales de San Basilio de Palenque con transformaciones impulsadas por la interacción del pueblo palenquero con las ciudades cercanas que trajo consigo la presión del uso de las tecnologías de la información y comunicación para estar conectados e informados, proceso iniciado en la década de los 80´s del siglo XX.
Educación integral de la sexualidad
Authors: May Novelo María Candelaria
Published: June 2024

La experiencia que se comparte alude a quince años de trabajo en el campo de la sexualidad impartiendo el Curso "Educación de la Sexualidad" en la Unidad 31-A de la Universidad Pedagógica Nacional (UPN) Subsede Valladolid en el estado de Yucatán, México. La impartición del curso se fortalece con el enfoque de educación integral de la sexualidad y se reconoce un campo del conocimiento necesario a abordarse en la formación académica de las personas que se forman como Licenciadas en  Intervención Educativa (LIE) en la Universidad Pedagógica Nacional, por los cambios en la forma de reconocer, comprender y aceptar la diversidad en todas sus expresiones en el pensamiento de las personas alumnas toman el curso, se aprecia y valora que este espacio formativo habilita de mejor forma al estudiantado para su futuro actuar en el campo laboral. Las personas que toman este curso además de aprender sobre su propio cuerpo y sexualidad, se habilitan como educadoras sexuales que pueden ser apoyo para otras personas que sufren violencias de cualquier tipo o tienen dudas sobre sus derechos sexuales y reproductivos.
Publicidade social: natureza, aspetos psicológicos e sucesso
Authors: Shubina Ivanna
Published: June 2024

A literatura acerca da publicidade social define o seu campo de atuação de uma maneira diversa e por vezes contrária: como um tipo de propaganda ou elemento de marketing social, ou mesmo como um fenómeno isolado. Não existe, na prática, consenso quanto a uma teoria consistente sobre publicidade social. A publicidade na vida social é tão necessária como na esfera económica. Este tipo de comunicação, graças às suas propriedades, pode rapidamente promover a difusão, de forma breve e precisa, da informação necessária para trazer à actualidade os problemas sociais ou para dar visibilidade a algumas instituições que atuam nessa área. Pretende-se, com esta informação, destacar aspetos importantes da realidade social, visando a solução dos problemas emergentes a ela ligados. Todas as formas e tipos de publicidade social apontam para a consecução desse objetivo.
ON THE ALAN-DAGESTAN HISTORICAL RELATIONSHIPS
Authors: ЧИБИРОВ Л.А.
Published: June 2024

Взаимоотношения ираноязычных предков алан-осетин с древними народами Дагестана уходят вглубь веков. О пребывании скифо-сарматских племен на территории Дагестана свидетельствуют археологические артефакты. Интенсивное освоение территории Дагестана аланами начиналось с первых веков н.э. с постепенным усилением к началу IIтыс. н.э. На рубеже V-VI вв. в Алании сложилось два крупных племенных объединения: Западная и Восточная Алания. Западная локализовалась в верховьях Кубани, Пятигорья, а Восточная Алания (Ирхан), охватившая территорию от Дарьяла до западных границ Дагестана, поддерживала контакты с существовавшими с IV по XII вв. государственными образованиями Дагестана: Дербент, Ладз, Табасаран. Особенно продолжительными (6 веков) и тесными эти отношения были с соседним княжеством Сарир. С распадом Хазарского каганата (Х в.) входившие в его состав Ирхан и Сарир не только расширили свои границы, но стали самыми крупными на Северном Кавказе. Сарир просуществовал до XIIвека, а Алания, после пика могущества (X-XI вв.), потерпела поражение от татаро-монгол и исчезла с политической карты мира. Контакты алан-осетин с народами Дагестана прервались на целых семь столетий.

The relations of the Iranian-speaking ancestors of the Alan-Ossetians with the ancient peoples of Dagestan go back centuries. Archaeological artifacts testify to the presence of Scythian-Sarmatian tribes on the territory of Dagestan. The intensive development of the territory of Dagestan by the Alans began from the first centuries A.D. with a gradual intensification by the beginning of the 11th century A.D. At the turn of the V-VI centuries, two large tribal associations formed in Alanya: Western and Eastern. The Western one was localized in the upper reaches of the Kuban, Pyatigorsk, and the Eastern Alania (Ikhran), which covered the territory from Daryal to the western borders of Dagestan, maintained contacts with the Dagestan state formations that existed from IV to XII: Derbent, Ladz, Tabasaran. These relations were especially long (6 centuries) and close with the neighboring principality of Sarir. With the collapse of the Khazar Khaganate (X century), Irkhan and Sarir, which were part of it, not only expanded their borders, but became the largest in the North Caucasus. Sarir existed until the XII century, and Alanya, after the peak of power (X-XI centuries), was defeated by the Tatar-Mongols and disappeared from the political map of the world. The contacts of the Alan-Ossetians with the peoples of Dagestan were interrupted for seven centuries.
Berlin of the Weimar Republic and the painting of the New Objectivity
Authors: Королёва А.Ю.
Published: June 2024

Статья посвящена исследованию региональных особенностей живописи новой вещественности на берлинской почве. Особенное положение принадлежащего к числу наиболее интенсивно развивающихся столиц мира делало главный город Веймарской республики необычайно притягательным для самых разных слоев населения, в том числе и художников. Актуальность темы определяется возрастающим в современной науке интересом к противопоставляемым авангарду реалистическим и фигуративным образам в искусстве XX столетия. Ее новизна заключается в рассмотрении произведений новой вещественности не как иллюстративной фиксации истории Берлина 1920 – начала 1930-х годов, а как своеобразного зеркала эпохи, преломившего жизнь мегаполиса в самых разных жанрах изобразительного искусства. Цель — выявить особенности «образа мира» в картинах вещественников, творящих в германской столице. Исследование проведено с применением формально-стилевого и социокультурного методов.

The article is devoted to the research of regional peculiarities of New Objectivity painting in the Berlin. The special position of the most intensively developing capitals of the world made the main city of the Weimar Republic unusually attractive for the most different strata of the population, including artists. The relevance of the topic is determined by the growing interest in modern science to the realistic and figurative images in the art of the 20th century opposed to the avant-garde. Its innovation lies in the consideration of the works of New Objectivity not as an illustrative record of life in Berlin in the 1920s and early 1930s, but as a kind of mirror of the era, which refracted the life of the metropolis in the most diverse genres of fine art. The aim is to reveal specific features of the "image of the world" in the paintings of the artists creating in the German capital. This was achieved through the application of formal-stylistic and socio-cultural methods.
“Zeitgeist” of the 1980s – early 2000s: French-German artistic theory and practice
Authors: Орлова Е.В.
Published: June 2024

В статье анализируется философско-мировоззренческое понятие «дух времени» в контексте научного диспута французского постструктуралиста Лиотара и немецких ученых — Юргена Хабермаса, Тильмана Борше, Манфреда Франка. Повествование включило обзор отдельных философских работ, которые имеют большое значение для развития художественной теории постмодерна. На примере кураторского замысла интернациональной выставки «Дух времени» («Zeitgeist», 1982, ФРГ, Берлин) выявлена идейная и образная основа «духа времени», связанного с принципами восприятия классического наследия в искусстве постмодерна. Сделана характеристика крупных произведений художников Йозефа Бойса, Зигмара Польке, Георга Базелица и др. Обоснован вывод о реконтекстуализации самого понятия «дух времени» в эпоху постмодерна. Данная работа выполнена с использованием иконографического и семиотического методов искусствоведческого анализа.

The article analyses the philosophical and world-view concept of “spirit of the times” in the context of a scientific debate between the French poststructuralist Jean-François Lyotard and German scientists — Jürgen Habermas, Tilman Borsche, Manfred Frank. The narrative includes an overview of selected philosophical works that are important for the development of postmodern artistic theory. The curatorial concept of the international exhibition "Zeitgeist" ("Zeitgeist", 1982, FRG, Berlin) provides an illustrative example of the ideological and figurative basis of the "spirit of time", which is connected with the principles of perception of the classical heritage in the art of postmodernity. A description of the major works of artists Joseph Beuys, Sigmar Polke, Georg Baselitz, and others is made. The conclusion regarding the recontextualisation of the concept of "zeitgeist" in the postmodern era is substantiated. This work was carried out using iconographic and semiotic methods of art history analysis.