bluuebunny/crossref_metadata_2025 huggingface dataset:
Residuos de resina de pino, grasas animales y vegetales en dos recipientes cerámicos de la Edad del Bronce I —fase Cogotas I— procedentes de La Peña del Moro (Navas de Oro, Segovia)
Authors: Martín Vela Raúl
Published: July 2024

El presente artículo describe los resultados del análisis de residuos realizado en dos recipientes cerámicos procedentes del castro de la Edad del Bronce de La Peña del Moro, en Navas de Oro, Segovia. Los datos obtenidos mediante cromatrografia de gases (GC-MS) revelan la presencia de grasas animales y vegetales, destacando los restos de resina de pino identificados en las paredes de dos de las cuatro vasijas analizadas. También se investiga la función específica de ambas cerámicas a través del análisis de residuos orgánicos preservados en su interior ofreciendo un testimonio de las diversas actividades en las que probablemente fueron utilizadas. En la discusión de nuestro trabajo, y, apoyándonos en datos arqueológicos, históricos y etnográficos, hacemos especial hincapié en el empleo de la resina de pino durante la Prehistoria. De forma muy sintética se enumerarán algunos usos de la savia del pino recogidos en las fuentes clásicas, con el objetivo de intentar extrapolar algunas de sus aplicaciones por parte de la comunidad de Cogotas que habitó el asentamiento.
Sacra privata: posibles indicadores materiales de culto doméstico en una ciudad romana de los Vascones (Los Bañales de Uncastillo, Zaragoza)
Authors: Pintado Javier Andreu
Published: July 2024

El presente trabajo da noticia de tres singulares piezas metálicas inéditas, en bronce y plomo, recuperadas entre 2016 y 2022 en las excavaciones arqueológicas en curso en la ciudad romana de Los Bañales de Uncastillo (Zaragoza), en el territorio de los antiguos Vascones. Las piezas –representaciones de Amor, de una tortuga probablemente relacionada con Mercurio y de una pequeña miniatura de templo o naiskos– se estudian desde el punto de vista iconográfico y simbólico, se propone una datación para las mismas y se argumenta, con paralelos formales y tipológicos varios, que tal vez formaron parte de lararia de culto doméstico por lo que contribuyen a nuestro conocimiento sobre la religiosidad privada en una ciudad romana del interior de la provincia Tarraconensis. Se reivindica y revisa, también, el papel de este tipo de pequeñas estatuitas votivas como indicadores de sacralidad para el estudio de los sacra privata romanos y de la religiosidad en ámbito doméstico en época altoimperial romana.
Nuevas propuestas para viejas excavaciones: acerca de las cabañas de la Edad del Bronce del Sector A de Los Tolmos (Caracena, Soria)
Authors: Sánchez Polo Alejandra
Published: July 2024

Los Tolmos, en Caracena, provincia de Soria, es un yacimiento de referencia para el estudio del Bronce Medio en la Meseta Norte. Su excavación durante las décadas de los 70 y los 80 del pasado siglo conllevó el hallazgo de varias tumbas de inhumación y de dos cabañas derribadas que se atribuyeron al grupo arqueológico de Cogotas I. El objetivo del presente artículo es valorar la pertenencia de este sitio clave en su clásica adscripción a la fase Proto-Cogotas I. Se ha tratado de reconsiderar los materiales arqueológicos depositados en el Museo Numantino de Soria que corresponden a los niveles de las cabañas y de una inhumación, así como al estrato situado inmediatamente sobre ellos del Sector A. Todo ello ha sido analizado de forma crítica y recurriendo a técnicas actuales que incluyen el estudio bioarqueológico y la datación radiométrica de los restos humanos previamente documentados, así como de otro fragmento errático, localizado por azar. Estos resultados, junto con el estudio de la cerámica, de la relectura de los materiales publicados y la revisión de los inventarios disponibles, han permitido reubicar la construcción, el mantenimiento y el derrumbe de las cabañas en el tránsito del III al II milenio a. C. y enriquecer su interpretación social.
Caracterización arqueométrica de un conjunto de cuentas de vidrio procedentes del oppidum vetón de Ulaca (Solosancho, Ávila)
Authors: Pinilla Gisbert Alejandro , Rodríguez-Hernández Jesús , Agua Martínez Fernando , Díaz-Sánchez Carlos , Quijada Sánchez Fátima , Ruiz Zapatero Gonzalo , Álvarez-Sanchís Jesús R. , Villegas Broncano Mª Ángeles , García-Heras Manuel
Published: July 2024

Se ha realizado un estudio arqueométrico de un conjunto de cuentas de vidrio halladas en el oppidum vetón de Ulaca –Solosancho, Ávila–. Las muestras se asocian a dos contextos, la necrópolis y el Torreón, fechados entre los ss. II y I a. C. El objetivo principal ha sido determinar su composición química, sus características tecnológicas incluyendo los cromóforos responsables de su coloración, así como su posible procedencia geográfica y estado de conservación. Para ello, el conjunto se analizó mediante técnicas convencionales como lupa binocular, microscopía electrónica de barrido de emisión de campo –MEBEC–, junto con microanálisis de dispersión de energía de rayos X –EDS– y espectrofotometría UV-Vis. Los resultados indican que todas las cuentas se elaboraron con un vidrio de silicato sódico cálcico de base natrón y bajo contenido de óxido de magnesio conocido como LMG –low magnesium glass–. La comparación de su composición química con la composición de otras cuentas de vidrio halladas también en contextos de la Edad del Hierro permite demostrar su posible procedencia del Mediterráneo oriental. Además, se identificó una cuenta muy alterada que no es de vidrio, sino muy probablemente de fayenza. La presencia de vidrios foráneos tanto en la necrópolis como en el Torreón sugiere que este material debió ser un bien preciado por las comunidades vetonas que habitaron Ulaca.
A pesquisa interventiva na construção do conhecimento de um mestrado profissional em educação
Authors: Pereira Antonio , Alves Érica Valéria , Santos Jocenildes Zacarias , MIRANDA SILVA Marta Rosa F.  A.
Published: July 2024

Este artigo é resultado de uma investigação em andamento sobre a pesquisa de intervenção em educação no Programa de Pós-Graduação em Educação - Mestrado Profissional em Educação de Jovens e Adultos (MPEJA), da Universidade do Estado da Bahia (UNEB). Buscou-se responder, pela análise de conteúdo dos Trabalhos de Conclusão de Curso, a questão: O que é a pesquisa de natureza interventiva em educação e como vem configurando na produção de conhecimento do Mestrado Profissional em Educação de Jovens e Adultos? O objetivo é compreender como essa natureza de pesquisa vem se constituindo nesse Programa, explicitando as suas contradições e possibilidades de conhecimentos. Os resultados, em linhas gerais, demonstram que o Programa concretiza essa natureza de pesquisa, inova quanto aos métodos ativos de investigação, por exemplo, estudos descritivos propositivos, bem como em novos dispositivos de recolha de informações, no entanto, tem fragilidades na organização, análise, interpretação e inferências das informações colhidas das intervenções, o que implica em resultados investigativos frágeis, embora apresente produtos que transformam as condições pedagógicas da EJA.
O acesso à Justiça e seus obstáculos
Authors: Degni-Segui René
Published: July 2024

«O acesso ao tribunal deve ser relativamente fácil para os litigantes… Esta é uma condição de boa justiça». Essa reflexão de René Cassin nos fornece, de imediato, a problemática do nosso estudo, a saber a dialéctica entre o justiciável e a justiça. Esta é feita para aquele, lembra o Professor Rivero, na medida em que, «a justiça é um serviço público cuja razão de ser é o usuãrio». Esta é a «evidência que provavelmente escapará aos olhos do especialista e que o eminente jurista recomenda fortemente que tenhamos em mente».
Comparison of intraoperative hemodynamics in classical and single-port adrenalectomy
Authors: Shikhmagomedov Sh. Sh. , Rebrova D. V. , Alekseev M. A. , Krasnov L. M. , Fedorov E. A. , Chinchuk I. K. , Chernikov R. A. , Rusakov V. F. , Sleptsov I. V. , Sablin I. V. , Kuleshov O. V.
Published: July 2024

BACKGROUND: Pheochromocytoma (PCC) is a tumor from the chromaffin tissue of the adrenal medulla, capable of hyperproduction of catecholamines. An important feature of pheochromocytoma, due to its hormonal activity, is the threat of sudden changes in hemodynamic parameters during surgical treatment. Retroperitoneoscopic access is currently becoming increasingly popular in the surgical treatment of chromaffin tumors of the adrenal glands. In clinical practice, two variants of the mentioned access are used: classic (three-port) and single-port. In this study, the influence of these options of retroperitoneoscopic access on intraoperative hemodynamic control was evaluated.

AIM: Comparison of treatment results and intraoperative hemodynamic parameters of patients with adrenal pheochromocytomas operated with single-port and three-port retroperitonescopic access options.

MATERIALS AND METHODS: A retrospective single-center cohort study was conducted on a sample of patients initially operated for pheochromocytoma at the Pirogov St. Petersburg State University High Medical Technology Clinic from October 2015 to February 2020 with intraoperative invasive hemodynamic control using PiCCO+ systems.

RESULTS: 47 patients were examined, 24 of whom underwent single–port adrenalectomy (included in the first group), 23 — three-port (second group). The average tumor size in the second group was larger (40.12±9.3 and 56.7±21.5, p<0.05), presumably, in this regard, the average duration of surgery was statistically significantly higher (73±21.5 and 111.7±36.1, p<0.05). The body mass index (BMI) of patients in the two groups did not differ statistically significantly. Intraoperatively measured values of maximum and minimum mean systolic and diastolic blood pressure, the number of episodes of increased diastolic blood pressure above 120 mmHg and their duration did not differ statistically in both groups (p>0.05). Episodes of increased systolic blood pressure above 180 mm Hg were more frequent in the second group (p=0.03), but their total duration in the two groups was without significant differences (p>0.05). Intraoperative consumption of antihypertensive drugs during the release of the adrenal gland and vasopressor drugs after compression of the central vein of the adrenal gland were similar. Blood pressure after compression of the central vein in the first and second groups did not differ significantly (p>0.05). No deaths and postoperative complications were registered in both groups.

CONCLUSION: Single-port modification of retroperitoneoscopic access with sufficient experience of the anesthesiological team and the operating surgeon does not lead to deterioration of hemodynamic control and operation results, being safe and effective in the surgical treatment of pheochromocytoma.
Apontamentos sobre as reformas curriculares brasileiras de 1990 a 2018: Reflexões críticas
Authors: Gonçalves Amanda Melchiotti , Deitos Roberto Antonio
Published: July 2024

O objetivo do artigo foi desenvolver reflexões críticas por meio de apontamentos descritivos sobre as reformas curriculares brasileiras de 1990 a 2018. Para tanto, considera a política neoliberal como sustentadora dessas reformas curriculares empreendidas no período. O procedimento metodológico do texto, pautado na abordagem qualitativa, dividiu-se em duas etapas: 1 – A relação entre Estado brasileiro e Organismos Internacionais; e 2 – Apontamentos sobre a reforma curricular brasileira de 1990 a 2018, a partir de um levantamento bibliográfico de autores que auxiliaram na interlocução das duas etapas. Ainda, na segunda etapa, utilizamos a análise de conteúdo de Bardin (2016) para extrairmos as interpretações históricas contidas nos documentos oficiais das reformas curriculares brasileiras do período. Com base nas alternâncias conceituais entre capacidade, habilidades, competências e competências socioemocionais presente nas proposições curriculares oficias brasileiras, foi possível observarmos a centralidade do estabelecimento de currículos por resultado, o que nos permitiu a codificação do que denominamos de padronização curricular avaliativa. Por meio dessas reflexões, constatamos a integralização de um projeto pedagógico de educação orientado ao propósito socioeconômico e político em curso.
Perwujudan Maskulinitas dalam Lagu Campursari Karya Didi Kempot dan Denny Caknan
Authors: Prasetyo Gilang Tegar , Sulistyowati Sulistyowati
Published: July 2024

Penelitian ini bertujuan untuk mendeskripsikan perbedaan perwujudan maskulinitas beserta konteksnya dalam lagu-lagu Campursari karya Didi Kempot dan Denny Caknan. Penelitian ini berjenis deskriptif kualitatif. Data penelitian ini adalah kata, frasa, dan kalimat yang menceritakan konteks dan perwujudan maskulinitas pada 3 lagu karya Didi Kempot, yaitu Pokoke Melu, Suket Teki, Terkintil-kintil, dan 3 lagu karya Denny Caknan, yaitu Satru 2, Kartonyono Ninggal Janji, Sampek Tuwek yang masing-masing memiliki kemiripan tema. Pengumpulan data dilakukan dengan studi dokumentasi, sedangkan analisis data menggunakan teori area maskulinitas Chafetz beserta penjelasan terkait konteks lagu. Hasil penelitian menunjukkan bahwa lagu-lagu Denny Caknan menunjukkan aspek fungsional, sifat ambisius, dan keinginan sukses dalam hal percintaan yang tidak ditunjukkan dalam lagu-lagu Didi Kempot.
Tindak Tutur Ekspresif Netizen Pada Pemberitaan Konflik Palestina-Israel di Sosial Media Instagram
Authors: Adlina Adlina , Martutik Martutik , Susanto Gatut
Published: July 2024

The purpose of this study was to expland the form of expressive speech and speech strategy by netizens from conflict of Israel-Palestina news on instagram. This type of research is qualitative research using descriptive methods, especially by employing Searle’s theory of speech acts. Data in this reseach were word, phrases, clauses and sentences that represent the form of expressive speech and speech strategy. Based on the results of the study, it was found five types form of expressive speech, namely condolence speech, insinuating speech, angry speech, complaining speech, and humor speech and four types of speech strategy, namely strategy of speaking frankly without preamble, strategy of speaking speaking with positive politeness, strategy of speaking with negative preamble and the strategy speak vaguely. Based on the results of the study, it can be concluded that the the form of expressive speech by netizens from Israel-Palestina news is a stimulus response from the news. The strategy of expressive speech caused by personality, pretension, and speaker purpose. The form of expressive speech determines the expressive speech strategy.
Gangguan Fonetik pada Penyandang Down Syndrome di SLBN Karanganyar Kabupaten Karanganyar
Authors: Pakerti Falah Ageng , Tiani Riris
Published: July 2024

Kemampuan anak dalam linguistik dapat diukur dari kemampuanya dalam Psikolinguistik. Tahap pemerolehan bahasa mencakup proses kompetensi dan performasi. Namun, dalam kondisi tertentu ada beberapa kondisi yang menghambat proses dalam Psikolinguistik. Penghambat tersebut disebabkan oleh ketidaknormalan fisik maupun mental, salah satu contoh kelainan Down syndrome. Down syndrome merupakan kelainan yang disebabkan kelebihan kromosom 21 yang mengakibatkan kelainan secara fisik dan mental sehingga menyebabkan kemampuan berbicara terganggu karena alat artikulator yang tidak sempurna. Keterbatasan inilah yang membuat anak penyandang Down syndrome mengalami gangguan berbicara. Penelitian ini bertujuan untuk menguraikan  pola-pola penyimpangan fonetik yang terjadi pada anak penyandang Down syndrome. Penelitian ini bersifat kualitatif menggunakan subjek jamak yang terdiri dari tiga orang informan penyandang Down syndrome di SLBN Karanganyar, Kabupaten Karanganyar. Pelafalan yang tidak mampu dilafalkan oleh anak penyandang Down Syndorme konsonan /z/, /sy/,/ny/,/y/,/x/ informan 1, /sy, /ny/, /x/ informan 2, /z/, /sy/, /ny/, dan /x/ informan 3. Penyimpangan fonetik yang terjadi pada pelafalan anak penyandang Down syndrome yang ditemukan yakni penghilangan dan perubahan bunyi.
Il polimorfismo dei verbi in -isco. La storia dell’identità in via di definizione
Authors: Grochowska-Reiter Anna
Published: July 2024

The paper discusses the problem of overabundance in third-conjugation Italian verbs. It provides a detailed diachronic analysis of grammar compilations to examine how verbs with a dual inflectional paradigm were described and how their usage has changed over the centuries. Extensive research into 59 grammar books intended for both native speakers and foreigners published in Italy and abroad form the 16th to the 19th century has shown that overabundance in the third conjugation was mentioned already in the earliest works of this type. Over time the interest in the topic grew even further as scholars explored its various aspects. The reconstruction of grammatical practice throughout centuries has uncovered the evolution of some verbs and their trajectory. In particular, it was possible to trace the development of: 1) verbs whose alternative, stylistically marked, form has become obsolete and exists only as an -isco form in modern Italian (ferire, languire, patire, perire, tradire); 2) verbs whose usage was unstable over centuries, with one form or the other predominating intermittently, until only one remained in use (tossire); and 3) verbs that have maintained a dual inflectional paradigm for the whole analysed period (aborrire, applaudire, assorbire, avvertire, inghiottire, mentire and nutrire).
Exploring the coupling mode of water and fertilizer for improving growth, fruit quality, and yield of the pear in the arid region
Authors: Li Tianle , Gao Zhijian , Bai Xinlu , Yu Sihai , An Shijie , Zheng Qiangqing , Tang Zhihui , Zhi Jinhu
Published: July 2024

Considering the pear in the arid region as the research object, single-factor testing and water–fertilizer coupling testing were conducted. The response of pear tree growth to water, nitrogen, and phosphorus was explored and provided a theoretical basis for efficient water and fertilizer management. Among them, the single-factor test set water, nitrogen, and phosphorus as the three factors, and five levels were set. Screening out W3, W4, N3, N4, P3, and P4 promoted plant nutrient uptake and fruit quality. Eight treatments were set up in the water and fertilizer coupling test: Treatment 1 (T1, W3N3P3), Treatment 2 (T2, W3N3P4), Treatment 3 (T3, W3N4P3), Treatment 4 (T4, W3N4P4), Treatment 5 (T5, W4N3P3), Treatment 6 (T6, W4N3P4), Treatment 7 (T7, W4N4P3), and Treatment 8 (T8, W4N4P4). The results showed that the leaf area index of the T1, T2, T3, and T4 treatments was significantly higher than that of the other treatments at maturity. The yield, single fruit weight, and primary fruit rate were the highest under T3 treatment. The gray correlation degree analysis of fruit quality showed that the T3 treatment had the highest degree of correlation and ranking of each fruit quality index, indicating that the T3 treatment had the highest fruit quality. The yield model showed that irrigation with 6510.06 m3 hm−2, nitrogen fertilizer with 337.5 kg N hm−2, and phosphate fertilizer with 262.5 kg P hm−2 had the best yield. A detailed investigation of pear tree growth and fruit quality showed that the T3 treatment had the best fruit growth and development performance, and the pear fruit quality was the best.
Considerations for applying emerging technologies in paediatric laboratory medicine
Authors: Lang Tim , Geaghan Sharon , Loh Tze Ping , Mak Chloe , Papassotiriou Ioannis , Kyriakopoulou Lianna G.
Published: July 2024

Emerging technology in laboratory medicine can be defined as an analytical method (including biomarkers) or device (software, applications, and algorithms) that by its stage of development, translation into broad routine clinical practice, or geographical adoption and implementation has the potential to add value to clinical diagnostics. Paediatric laboratory medicine itself may be considered an emerging area of specialisation that is established relatively recently following increased appreciation and understanding of the unique physiology and healthcare needs of the children. Through four clinical (neonatal hypoglycaemia, neonatal hyperbilirubinaemia, sickle cell disorder, congenital adrenal hyperplasia) and six technological (microassays, noninvasive testing, alternative matrices, next generation sequencing, exosome analysis, machine learning) illustrations, key takeaways of application of emerging technology for each area are summarised. Additionally, nine key considerations when applying emerging technology in paediatric laboratory medicine setting are discussed.
Fuzzy fractional delay integro-differential equation with the generalized Atangana-Baleanu fractional derivative
Authors: Wang Guotao , Feng Meihua , Zhao Xianghong , Yuan Hualei
Published: July 2024

In this work, we consider a class of fuzzy fractional delay integro-differential equations with the generalized Caputo-type Atangana-Baleanu (ABC) fractional derivative. By using the monotone iterative method, we not only obtain the existence and uniqueness of the solution for the given problem with the initial condition but also give the monotone iteration sequence converging to the unique solution of the problem. Furthermore, we also give the continuous dependence of the unique solution on initial value. Finally, an example is presented to illustrate the main results obtained. The results presented in this study are new and open a new avenue of research for fuzzy fractional delay integro-differential equations with the generalized ABC fractional derivative.
A novel variant of the STAR gene: nonclassical presentation from Turkey
Authors: Aytaç Kaplan Emel Hatun , Gezdirici Alper , Kocabey Sütçü Zümrüt , Gökpinar İli Ezgi
Published: July 2024

Objectives

Lipoid congenital adrenal hyperplasia (LCAH) is a rare autosomal recessive disease caused by mutations in the steroidogenic acute regulatory protein (STAR) gene, expressed in the adrenal and gonadal tissues. In classical LCAH, individuals with 46, XY chromosomes present with a female appearance of the external genitalia due to insufficient androgen production. In the non-classical form, a milder phenotype is observed with male external genitalia. Here, we present a non-classical LCAH diagnosis with a newly identified c.266T>A (p.Ile89Asn) likely pathogenic homozygous variant in a 46, XY infant.

Case presentation

A three-month-and-thirteen-day-old male proband presented with clinical features of cortisol and mineralocorticoid deficiencies. The manifestation of salt-wasting syndrome occurred relatively late, and although the external genitalia appeared male, there was a mild virilization defect. The combination of mild impairment in androgen production and severe salt-wasting syndrome is an intriguing finding in our patient. Peripheral blood samples were obtained from the patient and his family. The newly identified variant, determined by next-generation sequencing analysis, was confirmed by segregation analysis showing carrier status in both parents.

Conclusions

We aim to contribute to the literature by elucidating molecular mechanisms by presenting an atypical presentation and a newly identified variant.
Crystal structure of (S)-1-phenylpropan-1-aminium (S)-(1-phenylpropyl)carbamate C19H26N2O2
Authors: Jiang Qiong-Feng , Ou Guang-Chuan
Published: July 2024

C19H26N2O2, orthorhombic, P212121 (no. 19), a = 5.254(2) Å, b = 12.172(6) Å, c = 29.088(13) Å, V = 1860.2(14) Å3, Z = 4, R

gt
(F) = 0.0509, wR

ref
(F
2) = 0.1345, T = 173 K.
Chinese Crude Oil Futures and Sectoral Stocks: Copula-Based Dependence Structure and Connectedness
Authors: Imran Zulfiqar A. , Ahad Muhammad , Ahmad Mobeen , Hameed Imran
Published: July 2024

China launched its first crude oil futures on 18th March 2018, with the primary objective of introducing its own hedging instrument in China. Our study responds to this objective by investigating the dependence structure based on time-variant and time-invariant copula, connectedness in various market conditions, and hedging effectiveness of oil futures with eleven GICS sectors in China using daily returns data from 19th June 2019 to 24th February 2024. Findings suggest that time-varying copula is a best fit for all the GICS sectors in China except for the Energy. Similarly, the results of time-varying (TVP-VAR) connectedness indicate that the oil futures are the net receiver of shocks in total, short (1–5 days), and long-time (5 to infinity) spillover. The oil futures can better offset portfolio losses during the down market than normal and up markets. Lastly, based on TVP-VAR, the hedging ratio, optimum portfolio weights, and hedge effectiveness are calculated. We find a positive hedge ratio across various pairs of assets, which reduces the assets’ volatility. Moreover, hedge ratios and optimum portfolio weights are non-constant over time. Our results significantly contribute to the scant literature on Chinese crude oil futures and have implications for investors and policymakers.
The crystal and molecular structure of (R)-sirtinol – C26H22N2O2 – a chemo-sensitive enhancer and ligand in metal complexes with important bio-inorganic applications
Authors: Bernal Ivan , Lalancette Roger A. , Hudaihed Ahmad , Kucheryavy Pavel
Published: July 2024

Sirtinol is a known inhibitor of sirtuin proteins – a family of deacetylases involved in the physiology of aging. Its crystalline structure has never been determined except when bound to Fe(III) where it participates in the seven-fold coordination of the metal or to Cu(II) where it acts as a bidentate or tridentate ligand. Herein, we describe the structure of this important molecule, as follows: (a) the prevalent form of the keto-enol tautomerism in the solid state, and (b) in solution. Do they match? If not, how? The crystals of (R)-sirtinol are characterized by a large number of π–π bonded interactions linking molecules in infinite ribbons, which, in turn, are linked by additional π–π interactions of a variety of types, and by hydrogen bonds. In the latter case, we confirm by NMR that the X-ray determined position of an important H atom is on a N atom rather than on an O, which is how the molecule is usually depicted.
Cellulose acetate sheet supported gold nanoparticles for the catalytic reduction of toxic organic pollutants
Authors: Ullah Fahim , Khan Adnan , Gul Kashif , Asiri Abdullah M. , Kamal Tahseen , Ali Nauman
Published: July 2024

Water contamination by toxic organic dyes represents a significant global challenge necessitating effective remediation strategies. Due to their high catalytic activity, considerable attention has been gained to metal-based nanocatalysts. Cellulose acetate sheets supported by gold nanoparticles through a reduction method were synthesized. The composite synthesized material presents a compelling platform for catalytic reduction in the remediation of toxic organic pollutants, ensuring controlled particle size and stability. In this study, the prepared cellulose acetate sheet (CAsheet) was dipped in a 0.001 M aqueous chloroauric acid (HAuCl4) solution and reduced by immersion in a 0.1 M sodium borohydride (NaBH4) aqueous solution. After the successful preparation of virgin cellulose acetate sheet (CAsheet) and gold-supported cellulose acetate sheet (Au-CAsheet) samples were assessed by scanning electron microscopy (SEM), X-ray crystallography (XRD), energy dispersive X-rays spectroscopy (EDX), and Fourier transform infrared spectroscopy (FTIR) analysis. The catalytic reduction reaction of toxic compounds i.e. reduction of 4-nitroaniline (4-NA), Congo red (CR), and reactive yellow (RY-42) by using NaBH4. The catalytic activity of the Au-CAsheet was exhibited by the reaction rate constant (k
app) values 0.3189, 0.1596, and 0.1593 min−1 for CR, 4-NA, and RY-42 respectively. This kind of procedure for Au-CAsheet synthesis may be valid for different applications in catalysis, sensing, and environmental application.
Amikor „a legjobb hely a világon az itt, és a legjobb idő a most” volt (I.)
Authors: Csönge Tamás
Published: July 2024

Csönge Tamás kétrészes esszéje a 80-as és 90-es évek időutazós filmjei kapcsán vizsgálja, hogy a kései kapitalizmus tömegkultúrájában miképpen kolonizálta az abszolút jelen képzete a történelmi múltat és a jövőt. A szerző arra mutat rá, hogy a történeti tudat eltűnése és az utópikusság elsorvadása, vagyis az idő bezáródásának gondolata éppen az idősíkok relativitását és egymásra hatását tematizáló narratívákban válik igazán feltűnővé.ndolata éppen az idősíkok relativitását és egymásra hatását tematizáló narratívákban válik igazán feltűnővé.
A REPÚBLICA PLATÔNICA E SUAS IMAGENS – considerações sobre um modelo de sociedade
Authors: Barros José D'Assunção
Published: July 2024

Platão foi um dos primeiros pensadores conhecidos a se empenhar na construção de um modelo de cidade ideal. Neste artigo, alguns aspectos desse modelo são examinados, tomando-se por base textos da obra A República. Atenta-se, em particular, para as metáforas utilizadas por Platão na exposição de seu modelo de cidade, principalmente aquela que se implícita no mito da metalurgia, vista como possibilidade de naturalizar diferenças individuais e sociais, e ainda a da música, vista como possibilidade de repensar a harmonização das diferenças. Além disso, são examinadas as tensões entre os aspectos igualitários e autoritários que hoje são percebidos no modelo platônico. O sistema educacional proposto por Platão também é abordado, atentando-se para o seu papel na consolidação de diferenças no modelo proposto
CONTEXTURAS IDENTITÁRIAS DE DOCENTES DE LÍNGUAS
Authors: Lourenço Rosyanne Louise Autran , Santos Eliana Barbosa dos , Silva Lucinete Maria da
Published: July 2024

O presente artigo tem como objetivo investigar as contexturas identitárias de docentes de línguas acerca da visão apreciativa que possuem de suas praxis. Para tanto, empreendemos a discussão dos dados a partir do marco teórico constituído pelos construtos das identidades (DARVIN; NORTON, 2015; HALL, 2003; NORTON, 1995, 2000, 2011, 2013, 2016), do investimento (NORTON, 2013; NORTON; EARLY, 2011) e da agência (KLEIMAN, 2006; VAN LIER, 2010), com a finalidade de analisar as inter-relações que constituem essas contexturas. Trata-se de uma pesquisa qualitativa, de natureza interpretativista (CHIZZOTTI, 2010; MOITA LOPES, 1994), na modalidade estudo de caso (STAKE, 1994). O corpus da pesquisa consiste em narrativas verbais escritas (BARKHUIZEN, 2016; CONNELLY; CLANDININ, 1995; CLANDININ; CONNELLY, 2000) de três docentes profissionais, respectivamente, de língua espanhola, de língua portuguesa e de Libras. Os resultados obtidos apontam pontos de convergência nas conformações identitárias docentes, apesar das suas idiossincrasias e dos distintos objetos de trabalho. Concluímos que a natureza das contexturas identitárias desses profissionais desvela-se, concomitantemente, plural, pela diversidade de elementos historicamente situados que as compõem, e singular, dada à particularidade de aspectos comuns que perpassam os distintos relatos, suscitando reflexões acerca de suas imbricações para as próprias contexturas identitárias das pesquisadoras que empreenderam a investigação relatada.
A pilot study of the immune microenvironment of GI neuroendocrine carcinoma
Authors: McDonald Andrew , Avadhani Vaidehi , Oprea-Ilies Gabriela , Zakka Katerina , Lesinski Gregory B , Gbolahan Olumide B , Alese Olatunji
Published: July 2024

Gastroenteropancreatic high-grade (HG) neuroendocrine carcinoma (GEP-NEC) is an aggressive malignancy with limited treatment options and increasing incidence in the United States. Due to the rarity of the cancer and heterogeneity of the primary tumor location, data on GEP-NEC oncogenesis and its interaction with the host immune system are limited. A greater understanding of GEP-NEC and its tumor microenvironment (TME) would benefit efforts to develop more effective targeted therapies and rationally adapt immunotherapy to this disease. In this study, we profiled the expression of 770 unique genes using 21 biopsy samples from patients with GEP-NEC using the NanoString nCounter PanCancer IO 360 platform. Our results show several trends evident within the GEP-NEC TME. Greater expression of genes indicative of immune cell infiltration was present within the TME of patients <60 years of age and in patients with greater overall survival (OS). Tumors from patients with non-pancreatic NEC had diminished MHCII expression compared to pancreatic NEC, suggesting more prominent adaptive immune responses in the pancreatic GEP-NEC subtype. Patients with a >6 months OS had tumors with elevated NK cell gene signatures compared to patients with poor survival. Further, the analysis revealed numerous differentially expressed genes based on patient age, tumor location, response to treatment, and OS, which warrant future validation for assessing the relationship with clinical outcomes in patients.
MICROBIOME: Microbiomes in birds: a review of links to health and reproduction
Authors: Ottinger Mary Ann , Mani Shailaja , Krüger Sonja , Coverdale Brent , Willows-Munro Sandi , Combrink Leigh
Published: July 2024

Microbiomes have emerged as a key component essential for maintaining the health of an organism. Additionally, the roles of microbiomes are multifaceted, some unique to specific body areas and organs while others, particularly the gut microbiome, having broader effects on the entire organism. Comparative literature is emerging that compares microbiomes across mammals and birds. Domestic poultry have been the most extensively studied relative to their role in production agriculture. These data have provided a great deal of information about the effects of diet and nutritional requirements relative to the gut microbiome, productivity, and resilience to diseases. Conversely, limited research has been conducted on wild birds, despite them inhabiting a broad array of ecological niches and environments, providing a rich diversity in their adaptations to different habitats. Migratory birds and raptors are of particular interest. Migratory birds encounter a range of ecosystems and provide a link between allopatric populations. Raptors occupy high positions in the food chain, with potential exposure to biomagnification of environmental contaminants and pathogens. This review overviews our current understanding of the structure and function of avian microbiomes as related to avian health and reproduction in domestic and wild birds, highlighting knowledge gaps in need of further investigation for more effective conservation of rapidly declining avian populations.

Lay summary

Birds are among the most endangered organisms on the planet, vulnerable to many environmental challenges, including disease, loss of habitat, shortage of food resources, and climate-related change. They need to adapt to these challenges to survive and flourish. While the links between the gut microbiome, diet, resistance to infection, and behavior have been well studied in humans, laboratory animals, and domestic or captive birds, comparatively little is known about these associations in wildlife, where diet is expected to be more varied and seasonal. This is especially true for wild bird species. We review the information that is available on the microbiomes of both domestic and wild birds, highlighting knowledge gaps in our understanding of the health and reproduction of wild birds, toward furthering their conservation.
Novel PLCZ1 compound heterozygous mutations indicate gene dosage effect involved in total fertilisation failure after ICSI
Authors: Li Qing , Guo Juncen , Huang Gelin , Wu Nan , Chen Su , Dai Jing , Zhang Xueguang , Zhang Guohui , Zhi Weiwei , Yan Jierui , Zheng Rui , Yan Fei , Yan Zheng , Wu Ling , Wu Sixian , Ji Zhiliang , Zeng Jiuzhi , Lin Ge , Li Bin , Xu Wenming
Published: July 2024

In brief

PLCZ1 mutations are related to total fertilisation failure (TFF) after intracytoplasmic sperm injection (ICSI), characterised by abnormal oocyte oscillations. The novel PLCZ1 compound heterozygous mutations reported by this study were associated with TFF after ICSI, with one of the mutations indicating a gene dosage effect.

Oocyte activation failure is thought to be one of the main factors for total fertilisation failure (TFF) after intracytoplasmic sperm injection (ICSI), which could be induced by abnormal calcium oscillations. Phospholipase C zeta (PLCZ), a sperm factor, is associated with Ca2+ oscillations in mammalian oocytes. To date, some mutations in PLCZ1 (the gene that encodes PLCZ) have been linked to TFF, as demonstrated by the observed reduction in protein levels or activity to induce Ca2+ oscillations. In this study, normozoospermic males whose sperms exhibited TFF after ICSI and their families were recruited. First, mutations in the PLCZ1 sequence were identified by whole exome sequencing and validated using Sanger sequencing. Then, the locations of PLCZ1/PLCZ and the transcript and protein levels in the sperm of the patients were studied. Subsequently, in vitro function analysis and in silico analysis were performed to investigate the function–structure correlation of mutations identified in PLCZ1 using western blotting, immunofluorescence, RT-qPCR, and molecular simulation. Ca2+ oscillations were detected after cRNA microinjection into MII mouse oocytes to investigate calcium oscillations induced by abnormal PLCZ. Five variants with compound heterozygosity were identified, consisting of five new mutations and three previously reported mutations distributed across the main domains of PLCZ, except the EF hands domain. The transcript and protein levels decreased to varying degrees among all detected mutations in PLCZ1 when transfected in HEK293T cells. Among these, mutations in M138V and R391* of PLCZ were unable to trigger typical Ca2+ oscillations. In case 5, aberrant localisation of PLCZ in the sperm head and an increased expression of PLCZ in the sperm were observed. In conclusion, this study enhances the potential for genetic diagnosis of TFF in clinics and elucidates the possible relationship between the function and structure of PLCZ in novel mutations.
The history of interferon-stimulated genes in pregnant cattle, sheep, and pigs
Authors: Johnson Gregory A , Bazer Fuller W , Burghardt Robert C , Seo Heewon , Wu Guoyao , Cain Joe W , Pohler Ky G
Published: July 2024

In Brief

The trophectoderm of the elongating conceptuses of cattle, sheep, and pigs secrete high amounts of interferons that increase or induce the expression of interferon-stimulated genes (ISGs) in the endometrium. Research concerning ISGs, performed from 1995 through 2023, is reviewed in this manuscript.

Expression of the classical interferon (IFN) stimulated genes (ISGs) increases in the endometrial stroma and glandular epithelium (GE) through activation of signal transducer and activator of transcription (STAT) signaling in response to the secretion of IFN tau (IFNT) and IFN gamma (IFNG) by the conceptuses of ruminants, including cattle and sheep, and pigs, respectively. The first of the classical ISGs to be characterized was ISG15 in cattle. Classical ISGs are not expressed by the endometrial luminal epithelium (LE) due to the expression of interferon regulatory factor 2 (IRF2) in the LE that prevents the expression of ISGs in the LE. Classical ISG expression in the endometrium serves as a reliable indicator of conceptus health and elongation in cattle. There are also nonclassical ISGs that are upregulated in endometrial LE in response to progesterone (P4) that are further stimulated by IFNT in sheep, the intracellular signaling pathway responsible for IFN effects on expression is unknown. ISGs are also upregulated in extrauterine tissues including CL and peripheral blood mononuclear cells (PBMCs). The expression of ISGs by the PBMCs of cattle serves as an early prognosticator of pregnancy. The physiological roles of ISGs remain obscure, but evidence suggests that they are at least in part involved in modifying the immune system to support endometrial remodeling necessary for the successful implantation of the conceptus. Our understanding of these ISGs is primarily the result of work from the laboratories of Drs Fuller Bazer, Thomas (Tod) Hansen, Gregory Johnson, Hakhyun Ka, Patrick Lonergan, Troy Ott, and Thomas Spencer.
En procura del bien común, la promoción de la justicia y la paz. Cuatro años del Instituto de la paz y el desarrollo (Ipazde)
Authors: Fonseca Ortiz Lina María , Inampués Borda Andrés
Published: July 2024

La creación del Instituto para la Paz y el Desarrollo (Ipazde) se remonta al 2018 cuando se pensó en un escenario que coadyuvará al desarrollo de la misión institucional e integración multicampus por medio del diseño y gestión de proyectos de corresponsabilidad social que se centrarán en la investigación y estudio de la paz imperfecta, así toma relevancia y se crea mediante el Acuerdo 16 del Consejo Superior emanado en mayo del 2019. Su misión se inspira en el pensamiento cristiano tomista para promover los estudios y praxis de la paz y el desarrollo sostenible, desde las funciones sustantivas de docencia, investigación y proyección social para el reconocimiento y generación de conceptos, teorías, enfoques, metodologías y prácticas, que ayuden a superar las violencias, gestionar y transformar los conflictos a partir del respecto de la dignidad humana, las mediaciones, el empoderamiento para la convivencia, la promoción de la justicia social y el bien común.
Los nuevos sujetos educativos para las transiciones a la paz
Authors: Moya Urueña Daniel
Published: July 2024

Reconociendo las limitantes al hablar de “transición” para describir lo que acontece en Colombia en el marco del conflicto armado—uno de los más longevos y sangrientos del mundo moderno—, no  por ello se desconoce la coyuntura en la que la sociedad colombiana se encuentra: un pasado y presente de graves y sistemáticas violaciones a los derechos humanos y al derecho internacional humanitario (DIH) por parte de los grupos armados legales e ilegales, lo que impone la necesidad de la reflexión y debate colectivo para comprender el camino hacia adelante. La educación, por supuesto, no queda exenta de esta responsabilidad histórica y se convierte, más bien, en escenario de nuevos sujetos y procesos educativos para facilitar la compleja y difícil transición a la paz.
En este artículo se exponen algunas bases ético-políticas de la construcción de paz, pensadas desde el ejercicio docente universitario. Se refiere a la educación frente a los retos que esta puede asumir en las transiciones a la paz. Luego, se mencionan algunas experiencias significativas que se han liderado desde la Universidad Santo Tomás (USTA), seccional Tunja, en pedagogía e investigación para la paz, incluyendo la cátedra de paz en alianza con los mecanismos de justicia transicional. Se concluye con reflexiones sobre los nuevos sujetos educativos que emergen en las transiciones a la paz.
Redimensión del Programa de Apoyo Integral al Docente Tomasino (PAID)
Authors: Tibocha Niño Astrid , Orozco Carlos A. , Burgos Alomía Leidy V.
Published: July 2024

Desde la Vicerrectoría Académica General y la Unidad de Desarrollo Curricular y Formación Docente (UDCFD), se retomó el liderazgo de Programa de Apoyo Integral al Docente Tomasino PAID en la USTA. Inicialmente, para la consolidación de este programa, se tuvo en cuenta la importancia de apoyar al docente en el desarrollo de sus intereses y estilos de vida, entre otros aspectos. De igual manera, también se identificó que el apoyo al docente a través de este Programa es una estrategia que aporta en el crecimiento profesional y se alinea con lo contemplado en las Políticas y Lineamientos sobre Desarrollo Integral Docente Multicampus, que fueron formuladas en el 2020.
¿Las víctimas están en el centro? Discurso o realidad. Diálogos alrededor del rol de las víctimas en la justicia transicional y restaurativa
Authors: Noguera Sánchez Helber Armando
Published: July 2024

El encuentro sobre Justicia transicional y restaurativa nace como un espacio para generar discusiones, diálogos, reflexiones y balances en torno al papel que han jugado el principio de centralidad víctimas dentro del Sistema Integral de Verdad, Justicia, Reparación, y Garantías de No Repetición (SINVJRNR) desde su puesta en marcha, como fruto del acuerdo de paz firmado en el 2016 y entendido como el escenario de una justicia transicional y restaurativa. Un Sistema Integral que nació con la finalidad de ir en procura de la reparación de las víctimas mediante cada una de sus instituciones: Jurisdicción Especial para la Paz (JEP), Comisión de la Verdad (CEV) y la Unidad de Búsqueda de Personas dadas por Desaparecidas (UBPD), las cuales ponen en el centro la verdad como principio rector, para la materialización de una justicia restaurativa. Por ello una de las finalidades del encuentro era además crear discusiones poniendo el foco en los conceptos de verdad, justicia restaurativa, reparación, restauración, las garantías de no repetición y el principio dialógico, y cómo a partir de ello se ha dado centralidad a las víctimas en todo el proceso, y en evidenciar si esto se ha materializado efectivamente o si se ha quedado en una retórica discursiva.
Subvenciones ICETEX: logros y experiencias articuladas entre la DRI y la UDIES, para reconocer talentos tomasinos
Authors: Chaves Sáenz Margarita
Published: July 2024

El presente artículo destaca los retos, logros y experiencias del trabajo articulado entre la Dirección Nacional de Relaciones Internacionales (DRI) y la Unidad de Desarrollo Integral Estudiantil (UDIES), las cuales participaron con propuestas institucionales representando a la USTA en la “Convocatoria de Subvenciones” gestada por el ICETEX, entre abril y junio tanto en el 2022 como en el 2023.
Una mirada a la JEP como magistrados y docentes tomasinos
Authors: Inampués Borda Andrés
Published: July 2024

En el marco de la Trigésima Sexta Semana por la Paz celebrada del 3 al 10 de septiembre de 2023 el líder del Instituto de la Paz y el Desarrollo (Ipazde) conversó con el magistrado de la JEP Alejandro Ramelli Arteaga y a la magistrada auxiliar de la JEP Ana Cristina Portilla Benavides sobre educación, justicia y paz entre otros temas.
Mindful Meditation: A Potential Effective Therapeutic in Clinical Practice
Authors: Cho Kaley
Published: July 2024

Mindful meditation, a practice that entails directing one’s attention to the current moment without forming judgments, has been acknowledged as a potentially efficacious therapeutic intervention in clinical settings. Evidence indicates that mindfulness-based interventions can effectively assist individuals in coping with a range of mental health conditions, including anxiety, depression, and stress. Through the cultivation of enhanced self-awareness and emotional control via mindfulness practices, individuals have the potential to experience a decrease in symptoms, an increase in well-being, and an overall improvement in their quality of life. Furthermore, practicing mindfulness meditation can result in alterations in the structure and functioning of the brain, which are linked to improved cognitive capacities and emotional regulation. Integrating mindful meditation into clinical practice can offer patients valuable strategies for dealing with difficult situations and enhancing their long-term mental well-being and resilient ability.