bluuebunny/crossref_metadata_2025 huggingface dataset:
Cellular and clinical impact of protein phosphatase enzyme epigenetic silencing in multiple cancer tissues
Authors: Wiltshire Edward , de Moura Manuel Castro , Piñeyro David , Joshi Ricky S.
Published: March 2024

Background

Protein Phosphatase Enzymes (PPE) and protein kinases simultaneously control phosphorylation mechanisms that tightly regulate intracellular signalling pathways and stimulate cellular responses. In human malignancies, PPE and protein kinases are frequently mutated resulting in uncontrolled kinase activity and PPE suppression, leading to cell proliferation, migration and resistance to anti-cancer therapies. Cancer associated DNA hypermethylation at PPE promoters gives rise to transcriptional silencing (epimutations) and is a hallmark of cancer. Despite recent advances in sequencing technologies, data availability and computational capabilities, only a fraction of PPE have been reported as transcriptionally inactive as a consequence of epimutations.

Methods

In this study, we examined promoter-associated DNA methylation profiles in Protein Phosphatase Enzymes and their Interacting Proteins (PPEIP) in a cohort of 705 cancer patients in five tissues (Large intestine, Oesophagus, Lung, Pancreas and Stomach) in three cell models (primary tumours, cancer cell lines and 3D embedded cancer cell cultures). As a subset of PPEIP are known tumour suppressor genes, we analysed the impact of PPEIP promoter hypermethylation marks on gene expression, cellular networks and in a clinical setting.

Results

Here, we report epimutations in PPEIP are a frequent occurrence in the cancer genome and manifest independent of transcriptional activity. We observed that different tumours have varying susceptibility to epimutations and identify specific cellular signalling networks that are primarily affected by epimutations. Additionally, RNA-seq analysis showed the negative impact of epimutations on most (not all) Protein Tyrosine Phosphatase transcription. Finally, we detected novel clinical biomarkers that inform on patient mortality and anti-cancer treatment sensitivity.

Conclusions

We propose that DNA hypermethylation marks at PPEIP frequently contribute to the pathogenesis of malignancies and within the precision medicine space, hold promise as biomarkers to inform on clinical features such as patient survival and therapeutic response.
Suicidal ideation in Chinese patients with advanced breast cancer: a multi-center mediation model study
Authors: Zhang Yening , He Yi , Pang Ying , Su Zhongge , Wang Yu , Zhou Yuhe , Lu Yongkui , Jiang Yu , Han Xinkun , Song Lihua , Wang Liping , Li Zimeng , Lv Xiaojun , Wang Yan , Yao Juntao , Liu Xiaohong , Zhou Xiaoyi , He Shuangzhi , Song Lili , Li Jinjiang , Wang Bingmei , Tang Lili
Published: March 2024

Purpose

The pathways underpinning suicide ideation (SI) and certain physical and psychological factors in patients with advanced breast cancer remain unclear. This study develops and validates a mediation model that delineates the associations between several multidimensional variables and SI in Chinese patients with advanced breast cancer.

Methods

Patients with advanced breast cancer (n = 509) were recruited as study participants from 10 regional cancer centers across China from August 2019 to December 2020. Participants were required to complete five questionnaires using an electronic patient-reported outcomes (ePRO) system: 9 item- Patient Health Questionnaire (PHQ-9), Hospital Anxiety and Depression Scale (HADS), Insomnia Severity Index (ISI), 5-level EQ-5D (EQ-5D-5L), and MD Anderson Symptom Inventory (MDASI). Risk factors for SI were identified using multivariable logistic regression, and inputted into serial multiple mediation models to elucidate the pathways linking the risk factors to SI.

Results

SI prevalence was 22.8% (116/509). After adjusting for covariates, depression (odds ratio [OR] = 1.384), emotional distress (OR = 1.107), upset (OR = 0.842), and forgetfulness (OR = 1.236) were identified as significant independent risk factors (all p < 0.05). The ORs indicate that depression and distress have the strongest associations with SI. Health status has a significant indirect effect (OR=-0.044, p = 0.005) and a strong total effect (OR=-0.485, p < 0.001) on SI, mediated by insomnia severity and emotional distress.

Conclusions

There is a high SI prevalence among Chinese patients with advanced breast cancer. Our analysis revealed predictive pathways from poor health to heightened SI, mediated by emotional distress and insomnia. Regular management of distress and insomnia can decrease suicide risk in this vulnerable population.
Improving organic grape production: the effects of soil management and organic fertilizers on biogenic amine levels in Vitis vinifera cv., 'Royal' grapes
Authors: Kaya Ozkan , Yilmaz Turhan , Ates Fadime , Kustutan Fulya , Hatterman-Valenti Harlene , Hajizadeh Hanifeh Seyed , Turan Metin
Published: March 2024

Background

The integration of organic viticulture practices in grape cultivation represents a pivotal advancement towards sustainable agriculture, emphasizing the importance of environmentally friendly methods that enhance soil health, grape quality, and overall ecosystem biodiversity, thereby contributing significantly to the resilience and long-term sustainability of viticultural ecosystems. This study explored the effects of soil management practices, including chisel, disc harrow, and no tillage, as well as the impact of utilizing Antep radish, broccoli, and olive blackwater as fertilizer applications, on the biochemical composition, specifically biogenic amines (BAs), in the clusters of the 'Royal' grape cultivar within a vineyard setting.

Results

Throughout the three-year study, no tillage soil management consistently emerged as the most influential soil treatment for enhancing BAs in 'Royal' grape berries, especially in combination with Antep radish and olive blackwater fertilizer applications. Among fertilizer applications, the nontreated control vines consistently had the highest concentrations of critical BAs, such as putrescine, cadaverine, histamine, and dopamine, across different soil management practices. Among the soil management practices and fertilizer applications evaluated, the disc harrow soil management and olive blackwater fertilizer application generally yielded the lowest concentrations of BAs across several metrics.The PCA biplots indicated that experimental years have a similar effect on BA content in grape berries, with specific amines such as serotonin and dopamine being more affected in 2020, while cadaverine, histamine, spermidine, trimethylamine, and norepinephrine were more influenced in 2021, and putrescine, spermine, agmatine, and tryptamine in 2022.

Conclusion

These findings hold significant implications for organic agriculture, emphasizing the nuanced influence of soil management practices and organic fertilizers on the BA composition of grape berries. Our results indicate the potential of tailored agricultural strategies to enhance plant health and quality, aligning with the principles of sustainability and environmental stewardship inherent to organic farming.

Graphical Abstract
Glial-restricted progenitor cells: a cure for diseased brain?
Authors: Rogujski Piotr , Lukomska Barbara , Janowski Miroslaw , Stanaszek Luiza
Published: March 2024

The central nervous system (CNS) is home to neuronal and glial cells. Traditionally, glia was disregarded as just the structural support across the brain and spinal cord, in striking contrast to neurons, always considered critical players in CNS functioning. In modern times this outdated dogma is continuously repelled by new evidence unravelling the importance of glia in neuronal maintenance and function. Therefore, glia replacement has been considered a potentially powerful therapeutic strategy. Glial progenitors are at the center of this hope, as they are the source of new glial cells. Indeed, sophisticated experimental therapies and exciting clinical trials shed light on the utility of exogenous glia in disease treatment. Therefore, this review article will elaborate on glial-restricted progenitor cells (GRPs), their origin and characteristics, available sources, and adaptation to current therapeutic approaches aimed at various CNS diseases, with particular attention paid to myelin-related disorders with a focus on recent progress and emerging concepts. The landscape of GRP clinical applications is also comprehensively presented, and future perspectives on promising, GRP-based therapeutic strategies for brain and spinal cord diseases are described in detail.
Early reduction in cardiorespiratory fitness and diastolic reserve following radiation therapy for lung cancer
Authors: Thomas Georgia , Weiss Elisabeth , Del Buono Marco Giuseppe , Moroni Francesco , West Josh , Myers Rachel , Kontos Emily , Golino Michele , Abbate Antonio , Canada Justin M.
Published: March 2024

Background

Contemporary radiotherapy for the treatment of lung cancer is effective in targeting tumor tissue while limiting heart exposure, yet cardiac toxicity still occurs, often becoming clinically apparent years later. Cardiorespiratory fitness (CRF) is an independent predictor of cardiovascular, cancer-related, and overall mortality and may serve as a sensitive measure of subclinical cardiac toxicity following anti-cancer treatments. Prior work has demonstrated a significant relationship between reduced CRF and impaired left-ventricular (LV) diastolic reserve in cancer survivors following thoracic radiotherapy. The purpose of this study was to assess early longitudinal changes in CRF and cardiac function in patients with lung cancer following radiotherapy.

Methods

Ten patients (69 [61–76] years, 70% female) with lung cancer without known cardiovascular disease scheduled to receive radiotherapy involving a clinically-relevant heart dose (≥ 5 Gy to > 10% of heart volume) were evaluated prior to and following treatment. Changes in CRF (peak oxygen consumption [VO2peak], oxygen uptake efficiency slope [OUES]), cardiac function (LV ejection fraction [LVEF], rest and exercise diastolic function [diastolic functional reserve index (DFRI)]), cardiac biomarkers (N-terminal pro-brain natriuretic peptide [NT-proBNP], high-sensitivity C-reactive protein [hsCRP]), and health-related quality of life (HRQOL; Functional Assessment of Cancer Therapy-General-7 [FACT-G7]) were measured.

Results

The VO2peak was reduced at baseline (1.245 [0.882–1.605] L·min− 1; 70 [62–86] %-predicted) and significantly declined (1.095 [0.810–1.448] L·min− 1, P = 0.047; 62 [56–76] %-predicted, P = 0.005) at 6.0 [3.0–6.0] months post-radiotherapy. Similarly, a significant decline in the OUES was observed (1.63 [1.27–1.88] to 1.57 [1.12–1.75], P = 0.032). Systolic cardiac function was normal at baseline and did not change following radiotherapy (LVEF; 62 [56–65]% to 66 [57–68]%, P = 0.475). The DFRI significantly declined following radiotherapy (34.9 [22.7–41.6] vs. 12.8 [3.1–35.9]). The hsCRP increased significantly from 4.4 [1.4–5.8] to 6.1 [3.7–20.7] g/L, P = 0.047 with a trend towards higher levels of NT-proBNP (65 [49–125] to 121 [88–191] pg/mL, P = 0.110). Health-related quality of life significantly decreased (FACT-G7; 21.5 [18.8–25] to 15.5 [11.5–20]; P = 0.021) post-radiotherapy.

Conclusions

Patients with lung cancer receiving radiotherapy with a clinically-significant heart dose experience reductions in CRF (VO2peak, OUES) as early as six months following treatment with concurrent reductions in diastolic reserve (DFRI), HRQOL, and increases in cardiac biomarkers (NT-proBNP, hsCRP).
Irreversible methadone-induced GSTP1 downregulation in SH-SY5Y cells
Authors: Saify Khyber , Saadat Mostafa
Published: March 2024

Background

Methadone has been reported to downregulate the expression of glutathione S-transferase P1 (GSTP1) among nine antioxidant genes in SH-SY5Y cells after both short- and long-term treatment. GSTP1 plays a key role in the detoxification of many xenobiotics and is frequently associated with various diseases, especially tumors. The objective of this study is to determine whether this change is reversible.

Methods

Two different treatment protocols were used. The first protocol evaluated the reversibility of the GSTP1 mRNA change, while the second protocol evaluated the methylation status of the GSTP1 promoter site. To investigate the reversibility of the GSTP1 mRNA change, SH-SY5Y cells were treated with methadone. The drug was then removed from the medium and the cells were cultured in methadone-free medium for a period of time. GSTP1 mRNA levels were expressed as cycle threshold (Ct) values using TATA box-binding protein as a calibrator gene. Methylation at the promoter site was detected by bisulfite treatment.

Results

The analysis of variance revealed no significant change in GSTP1 mRNA levels in the cells after methadone was removed from the medium of methadone-treated cells. The study also examined the methylation status of a CpG island in the promoter of GSTP1 in the treated cells. The results demonstrate that although methadone downregulates the mRNA level of GSTP1 in treated cells, it does not induce methylation in the GSTP1 promoter region.

Conclusions

The expression of the GSTP1 remains downregulated even after methadone removal from SH-SY5Y cell culture medium; however, methylation of the GSTP1 promoter site does not play a role in this process.
Building typology of Albanian kulla stone houses in the Balkans
Authors: Jerliu Florina , Thaçi Kaltrina
Published: March 2024

This paper aims to establish a unified typology for the culturally significant kulla stone houses built in the cross-border region of Kosovo, Albania, and Montenegro during the 18th and 19th centuries. Despite some attempts at typological categorisation on the national level, a joint typology for this region currently needs to be improved. Based on existing literature and field research, the paper identifies the specificities of different geographical locations while validating the core attributes common to all typological variations. The findings suggest that the joint typological classification of kulla in the Balkans should primarily be based on architectural elements and, to some extent, setting, building materials and techniques, while functional composition is consistent across all types. The paper argues that defining a common typology for the Albanian kulla stone houses in the Balkans is crucial for evaluating, preserving, and developing kulla as serial properties and for their future regional development.
Submarine cable positioning using a residual convolutional neural network based on magnetic features
Authors: Liu Yutao , Wu Yuquan , Huang Liang , Yang Lei , Kuang Jianxun , Yu Wenjie , Wang Jianqiang , Xu Zhe , Li Gang
Published: March 2024

Accurate positioning is important for improving the efficiency of repairing submarine cables and reducing the related repair costs. The magnetic anomaly produced by a submarine cable can be used to estimate its vertical and horizontal positions. A novel approach using magnetic data for estimating the position of submarine cables based on the 1D residual convolutional neural network (RCNN) is investigated. Infinitely long ferromagnetic cylinder models with different parameters are used to generate data sets for model training and testing. Tests on noisy synthetic data sets show that the developed 1D RCNN method can capture detailed features related to the magnetic source position information, which is more accurate than the conventional Euler method in estimating the position of submarine cables. The developed 1D RCNN method has also been successfully applied to processing field data. Furthermore, the processing workflow of our 1D RCNN method is less noise-sensitive compared with the conventional Euler method. The proposed 1D RCNN method and its workflow open a new window for estimating the position of submarine cables using magnetic data.
The language and landscape of the law in relation to consent in minors
Authors: Dosani Sabina
Published: March 2024

This commentary reflects on two articles on consent in those under 18 years of age, known in law as ‘minors’. I consider why the language and landscape of the law in relation to consent in this age group can be alienating to psychiatrists, interrogate the legal complexities regarding consent in children and adolescents, refer to key aspects of relevant case law and end with practical suggestions that might improve clinical practice with cases that have the potential for legal complexity.
Tailoring Neoadjuvant Therapy in Human Epidermal Growth Factor Receptor 2–Positive Early Breast Cancer: Recent Advances and Strategies
Authors: Esteva Francisco J. , Katz Elena
Published: March 2024

Neoadjuvant HER2 Therapy: Beyond one-size-fits-all.
Health Insurance Navigation Tools Intervention: A Pilot Trial Within the Childhood Cancer Survivor Study
Authors: Park Elyse R. , Kirchhoff Anne C. , Donelan Karen , Perez Giselle K. , McDonald Aaron , Bliss Cayley C. , Foor Allyson , van Thiel Berghuijs Karely M. , Waters Austin R. , Durieux Natalie , Leisenring Wendy , Armstrong Gregory T. , Ponzani Colin , Lopez Ana , Vaca Lopez Perla L. , Battaglia Tracy , Galbraith Alison A. , Kuhlthau Karen A.
Published: March 2024

PURPOSE

Childhood cancer survivors are at increased risk for underinsurance and health insurance–related financial burden. Interventions targeting health insurance literacy (HIL) to improve the ability to understand and use health insurance are needed.

METHODS

We codeveloped a four-session health insurance navigation tools (HINT) intervention, delivered synchronously by a patient navigator, and a corresponding booklet. We conducted a randomized pilot trial with survivors from the Childhood Cancer Survivor Study comparing HINT with enhanced usual care (EUC; booklet). We assessed feasibility, acceptability, and preliminary efficacy (HIL, primary outcome; knowledge and confidence with health insurance terms and activity) on a 5-month survey and exit interviews.

RESULTS

Among 231 invited, 82 (32.5%) survivors enrolled (53.7% female; median age 39 years, 75.6% had employer-sponsored insurance). Baseline HIL scores were low (mean = 28.5; 16-64; lower scores better); many lacked knowledge of Affordable Care Act (ACA) provisions. 80.5% completed four HINT sessions, and 93.9% completed the follow-up survey. Participants rated HINT's helpfulness a mean of 8.9 (0-10). Exit interviews confirmed HINT's acceptability, specifically its virtual and personalized delivery and helpfulness in building confidence in understanding one's coverage. Compared with EUC, HINT significantly improved HIL (effect size = 0.94. P < .001), ACA provisions knowledge (effect size = 0.73, P = .003), psychological financial hardship (effect size = 0.64, P < .006), and health insurance satisfaction (effect size = 0.55, P = .03).

CONCLUSION

Results support the feasibility and acceptability of a virtual health insurance navigation program targeted for childhood survivors to improve HIL. Randomized trials to assess the efficacy and sustainability of health insurance navigation on HIL and financial burden are needed.
Increase in the count rates of ground-based cosmic-ray detectors caused by the heliomagnetic disturbance on 5 November 2023
Authors: Chilingarian A. , Karapetyan T. , Sargsyan B. , Zazyan M. , Knapp J. , Walter M. , Rehm T.
Published: March 2024

This letter presents a rare physical phenomenon associated with solar activity, manifesting in anomalies within neutron, electron, and gamma-ray fluxes in the atmosphere. Conventionally, the Earth's magnetic-field disturbances reduce cosmic-ray intensity reaching the surface. However, a temporary surge in cosmic-ray flux occurs intermittently known as the magnetospheric effect (ME). Our observations reveal that this effect predominantly induces a count rate increase in particle detectors positioned at middle latitudes on mountaintops. On November 5, 2023, a 2–3% increase in neutron monitors at mountain altitudes and up to 5% increase in thin plastic scintillators registering electrons and gamma rays was observed. This flux escalation coincided with a southward orientation of the interplanetary magnetic field. Importantly, we present, for the first time, the energy spectrum of the Magnetospheric Effect observed at two mountaintops: Aragats and Zugspitze. Simulations of low-energy proton interactions in the terrestrial atmosphere affirm the augmentation of low-energy cosmic rays. Protons, typically restricted by the geomagnetic cutoff, reached the Earth's atmosphere, generating detectable particle showers on the Earth's surface. To sum up, 1) we measure an increase in the count rate of magnetospheric origin using particle detectors located at mountain altitudes and middle latitudes; 2) for the first time, we measured the energy spectra of the particle fluxes during the magnetospheric effect with spectrometers located on Mount Aragats and Zugspitze; 3) particle flux enhancement coincides with the depletion of the horizontal component of the geomagnetic field; 4) we explain why the magnetospheric effect was observed at mountain altitudes and not at sea level.
MODY Probability Calculator Is Suitable for MODY Screening in China: A Population-based Study
Authors: Zhao Jing , Chen Yan , Ma Fuhui , Shu Hua , Zheng Li , Liu Yang , Li Xia , Xu Tao , Zhou Zhiguang , Zhou Kaixin
Published: March 2024

Context

Selecting appropriate individuals for genetic testing is essential due to the optimal treatment for maturity-onset diabetes of the young (MODY). However, how to effectively screen for MODY in China remains unclear.

Objective

To validate the performance of current screening strategies in selecting patients with MODY based on a nationwide type 2 diabetes cohort.

Methods

A panel of 14 MODY genes was analyzed from 1911 type 2 diabetes patients who were ages 15 to 35 years. Variants were evaluated according to the American College of Medical Genetics and Genomics guidelines. Based on this cohort, we simulated the 2 most frequently used screening strategies, including the traditional MODY criteria and the MODY probability calculator (MPC), to assess their ability to select patients with MODY.

Results

From a total of 1911 participants, 42 participants harbored pathogenic/likely pathogenic variants. The performance of the traditional criteria was sensitivity: 19.0%, specificity: 72.9%, positive predictive value (PPV): 1.6%, and missing rate: 81.0%. The optimal cut-off for MPC was 40.7%. Based on this cut-off value, the performance was sensitivity: 54.8%, specificity: 81.0%, PPV: 6.1%, and missing rate: 45.2%. Moreover, hemoglobin A1c, insulin treatment, and family history of diabetes have poor discrimination between MODY and young-onset type 2 diabetes.

Conclusion

The MPC is better than traditional criteria in terms of both sensitivity and PPV. To ensure more MODY patients benefit from optimal treatment, we therefore suggest that routine genetic testing be performed on all type 2 diabetes patients who are between the ages of 15 and35 years and have MPC probability value over 40.7%.
Reduction of cortical pulling at mitotic entry facilitates aster centration
Authors: Rosfelter Anne , de Labbey Ghislain , Chenevert Janet , Dumollard Rémi , Schaub Sebastien , Machaty Zoltan , Besnardeau Lydia , Gonzalez Suarez Daniel , Hebras Céline , Turlier Hervé , Burgess David R. , McDougall Alex
Published: March 2024

Equal cell division relies upon astral microtubule-based centering mechanisms, yet how the interplay between mitotic entry, cortical force generation and long astral microtubules leads to symmetric cell division is not resolved. We report that a cortically located sperm aster displaying long astral microtubules that penetrate the whole zygote does not undergo centration until mitotic entry. At mitotic entry, we find that microtubule-based cortical pulling is lost. Quantitative measurements of cortical pulling and cytoplasmic pulling together with physical simulations suggested that a wavelike loss of cortical pulling at mitotic entry leads to aster centration based on cytoplasmic pulling. Cortical actin is lost from the cortex at mitotic entry coincident with a fall in cortical tension from ∼300pN/µm to ∼100pN/µm. Following the loss of cortical force generators at mitotic entry, long microtubule-based cytoplasmic pulling is sufficient to displace the aster towards the cell center. These data reveal how mitotic aster centration is coordinated with mitotic entry in chordate zygotes.
The genome sequence of the Judas Tree Seed Beetle, Bruchidius siliquastri Delobel, 2007
Authors: Barclay Maxwell V. L. , Geiser Michael , Matsumoto Keita , Pash Emily ,   Natural History Museum Genome Acquisition Lab,   Darwin Tree of Life Barcoding collective,   Wellcome Sanger Institute Tree of Life Management, Samples and Laboratory team,   Wellcome Sanger Institute Scientific Operations: Sequencing Operations,   Wellcome Sanger Institute Tree of Life Core Informatics team,   Tree of Life Core Informatics collective,   Darwin Tree of Life Consortium
Published: March 2024

We present a genome assembly from an individual male Bruchidius siliquastri (the Judas tree Seed Beetle; Arthropoda; Insecta; Coleoptera; Chrysomelidae). The genome sequence is 375.6 megabases in span. Most of the assembly is scaffolded into 11 chromosomal pseudomolecules, including the X and Y sex chromosomes. The mitochondrial genome has also been assembled and is 15.81 kilobases in length. Gene annotation of this assembly on Ensembl identified 17,940 protein coding genes.
Digital Storytelling for Environmental Education on YouTube: Findings from Social Forestry Context
Authors:   School of Business and Management Institut Teknologi Bandung, Indonesia, Herutomo Anton , Dhewanto Wawan , Prasetio Eko Agus
Published: March 2024

Abstract. Digital storytelling is a method of telling stories using digital media. This method can be used for educational purposes including environmental education to support sustainability mindset. This study aimed to explore the use of digital storytelling for environmental education on Youtube in the context of social forestry in Indonesia. The research method used was Focus Group Discussion (FGD) and analyses using thematic coding. The findings from 15 professionals and experts in 3 FGD sessions showed that digital storytelling with Youtube can be an effective tool for environmental education. This is because YouTube as a digital storytelling media captures the attention of viewers, helps them understand complex environmental concepts, and promotes alignment to support sustainability. Digital storytelling in YouTube can be used to build relationships and collaboration among viewers in local and regional scope. Keywords: Social innovation, digital storytelling, environmental sustainability, focus group discussion, youtube
A Dual Bounding Framework Through Cost Splitting for Binary Quadratic Optimization
Authors: Bayani Mahdis , Rostami Borzou , Adulyasak Yossiri , Rousseau Louis-Martin
Published: March 2024

Binary quadratic programming (BQP) is a class of combinatorial optimization problems comprising binary variables, quadratic objective functions, and linear/nonlinear constraints. This paper examines a unified framework to reformulate a BQP problem with linear constraints to a new BQP with an exponential number of variables defined on a graph. This framework relies on the concept of stars in the graph to split the quadratic costs into adjacent and nonadjacent components indicating in-star and out-of-star interactions. We exploit the star-based structure of the new reformulation to develop a decomposition-based column generation algorithm. In our computational experiments, we evaluate the performance of our methodology on different applications with different quadratic structures. The quadratic component of the problem is dealt with in the column generation master problem and its subproblem. Results indicate the superiority of the framework over one of the state-of-the-art solvers, GUROBI, when applied to various benchmark reformulations with adjacent-only or sparse quadratic cost matrices. The framework outperforms GUROBI in terms of both dual bound and computational time in almost all instances.

History: Accepted by Andrea Lodi, Area Editor for Design & Analysis of Algorithms—Discrete.

Funding: The authors thank the Mitacs Accelerate Program for providing funding for this project. In addition, B. Rostami gratefully acknowledges the funding provided by the Canadian Natural Sciences and Engineering Research Council (NSERC) under a Discovery Grant [Grant RGPIN-2020-05395].

Supplemental Material: The online appendix is available at https://doi.org/10.1287/ijoc.2021.0186 .
Convergence and Stability of Coupled Belief-Strategy Learning Dynamics in Continuous Games
Authors: Wu Manxi , Amin Saurabh , Ozdaglar Asuman
Published: March 2024

We propose a learning dynamics to model how strategic agents repeatedly play a continuous game while relying on an information platform to learn an unknown payoff-relevant parameter. In each time step, the platform updates a belief estimate of the parameter based on players’ strategies and realized payoffs using Bayes’ rule. Then, players adopt a generic learning rule to adjust their strategies based on the updated belief. We present results on the convergence of beliefs and strategies and the properties of convergent fixed points of the dynamics. We obtain sufficient and necessary conditions for the existence of globally stable fixed points. We also provide sufficient conditions for the local stability of fixed points. These results provide an approach to analyzing the long-term outcomes that arise from the interplay between Bayesian belief learning and strategy learning in games and enable us to characterize conditions under which learning leads to a complete information equilibrium.

Funding: Financial support from the Air Force Office of Scientific Research [Project Building Attack Resilience into Complex Networks], the Simons Institute [research fellowship], and a Michael Hammer Fellowship is gratefully acknowledged.
Collaborative Vehicle-to-Grid Operations in Frequency Regulation Markets
Authors: Mak Ho-Yin , Tang Runyu
Published: March 2024

Problem definition: We study the operations of electric vehicles (EVs) providing frequency regulation services to the electric grid in vehicle-to-grid (V2G) systems. In particular, individually owned EVs collaboratively bid in the regulation market, coordinated by a platform that operates the network of charging equipment. We study how the platform determines optimal pricing incentives for drivers to plug in their EVs, accounting for heterogeneous driving schedules. Methodology/results: We model the platform’s pricing optimization problem as a bilevel program: At the upper level, the platform determines hourly rebates for EV owners to plug in their EVs and capacity bids in the regulation market; at the lower level, individual travelers optimize their travel and charging schedules in response to pricing incentives. To account for uncertainties and heterogeneity in regulation market prices and travel patterns, we adopt distributionally robust optimization techniques to formulate the problem as a mixed-integer second-order cone program. We conduct a computational study based on the California Household Travel Survey data set and actual frequency regulation prices. Our results show that the ability to offer time-varying rebates and install workplace chargers can significantly improve the V2G platform’s expected profits. Managerial implications: As EV adoption progresses past the nascent stage, V2G business models become more viable. Successful implementation of V2G provides economic incentive for switching to EVs, potentially helps sustain adoption growth, and complements the growth of renewable power by helping stabilize the grid. Our findings shed light on the design of driver incentives for V2G systems.

Funding: R. Tang acknowledges support from the National Natural Science Foundation of China [Grant 72201206].

Supplemental Material: The online appendices are available at https://doi.org/10.1287/msom.2022.0133 .
Quantile Optimization via Multiple-Timescale Local Search for Black-Box Functions
Authors: Hu Jiaqiao , Song Meichen , Fu Michael C.
Published: March 2024

Black-Box Quantile Optimization via Finite-Difference-Based Gradient Approximation

Risk management necessitates consideration of metrics such as quantiles to supplement conventional mean performance measures. In “Quantile Optimization via Multiple-Timescale Local Search for Black-Box Functions,” J. Hu, M. Song, and M. C. Fu consider the problem where the goal is to optimize the quantile of a black-box output. They introduce two new iterative multitimescale stochastic approximation algorithms utilizing finite-difference-based gradient estimators. The first algorithm requires 2d + 1 samples of the black-box function per iteration, where d is the number of decision variables. The second employs a simultaneous-perturbation-based gradient estimator that uses only three samples per iteration, irrespective of the number of decision variables. The authors prove strong local convergence for both algorithms and analyze their finite-time convergence rates through a novel fixed-point argument. These algorithms perform well across a varied set of benchmark problems.
Pott’s puffy tumour: a rare complication of sinusitis
Authors: Maenhout Marine , Gudelj Maxime , Gilbert Allison
Published: March 2024

Introduction: Pott’s puffy tumour is a rare entity defined by the presence of a subperiosteal abscess of the frontal bone associated with frontal osteomyelitis. Several predisposing conditions can lead to this entity, such as frontal sinusitis. Case description: We report the case of a 15-year-old patient who presented to the emergency department for headache, fever and forehead swelling. Computed tomography revealed severe pansinusitis complicated by a subperiosteal abscess associated with frontal osteomyelitis, leading to the diagnosis of Pott’s puffy tumour. The management combined intravenous antibiotics and surgical drainage of both the sinusitis and subperiosteal abscess. Discussion: Pott’s puffy tumour represents a rare but serious complication of frontal sinusitis. Clinicians should be aware of this potential complication as the diagnosis can be challenging at an early stage but may influence the subsequent prognosis.
Haematogenous pneumonia caused by Kocuria kristinae in a patient with a central venous catheter
Authors: Natale Raffaele , Nasti Clelia , Morena Annadora , Pasanisi Fabrizio , Santarpia Lidia
Published: March 2024

Kocuria kristinae is a Gram-positive commensal bacterium, rarely responsible for infection in immunocompromised patients. A 29-year-old woman affected by intestinal pseudo-obstruction and requiring home parenteral nutrition, was hospitalised for fever and shivering during the infusion through a long-term central venous catheter (CVC). Blood cultures were positive for K. kristinae infection. At a chest CT scan, two partially cavitated nodular lesions were evidenced. Meropenem antibiotic therapy was used locally and systemically, resulting in catheter use restoration. A chest CT scan two months later at follow-up showed two centimetric, fibrotic and disventilatory areas replacing the previous nodular thickenings. Kokuria kristinae was responsible for haematogenous pulmonary involvement with excavated nodules, requiring a differential diagnosis. Moreover, in the case of a CVC infection, in addition to the risk of right endocarditis, haematogenous pneumonia must also be considered.
Tandem neural network-assisted inverse design of highly efficient diffractive slanted waveguide grating
Authors: Luo Menglong , Lee Sang-Shin
Published: March 2024

Virtual reality devices featuring diffractive grating components have emerged as hotspots in the field of near-to-eye displays. The core aim of our work is to streamline the intricacies involved in devising the highly efficient slanted waveguide grating using the deep-learning-driven inverse design technique. We propose and establish a tandem neural network (TNN) comprising a generative flow-based invertible neural network and a fully connected neural network. The proposed TNN can automatically optimize the coupling efficiencies of the proposed grating at multi-wavelengths, including red, green, and blue beams at incident angles in the range of 0°–15°. The efficiency indicators manifest in the peak transmittance, average transmittance, and illuminance uniformity, reaching approximately 100%, 92%, and 98%, respectively. Additionally, the structural parameters of the grating can be deduced inversely based on the indicators within a short duration of hundreds of milliseconds to seconds using the TNN. The implementation of the inverse-engineered grating is anticipated to serve as a paradigm for simplifying and expediting the development of diverse types of waveguide gratings.
In-orbit dark count rate performance and radiation damage high-temperature annealing of silicon avalanche photodiode single-photon detectors of the Micius satellite
Authors: Yang Meng , Liao Sheng-Kai , Tang Wen-Shuai , Cai Wen-Qi , Li Yang , Yin Juan , Peng Cheng-Zhi
Published: March 2024

Silicon avalanche photodiode (APD) single-photon detectors in space are continuously affected by radiation, which gradually degrades their dark count performance. From August 2016 to June 2023, we conducted approximately seven years (2507 days) of in-orbit monitoring of the dark count performance of APD single-photon detectors on the Micius Quantum Science Experimental Satellite. The results showed that due to radiation effects, the dark count growth rate was approximately 6.79 cps/day @ -24 °C and 0.37 cps/day @ -55 °C, with a significant suppression effect on radiation-induced dark counts at lower operating temperature. Based on the proposed radiation damage induced dark count annealing model, simulations were conducted for the in-orbit dark counts of the detector, the simulation results are consistent with in-orbit test data. In May 2022, four of these detectors underwent a cumulative 5.7 hours high-temperature annealing test at 76 °C, dark count rate shows no measurable changes, consistent with annealing model. As of now, these ten APD single-photon detectors on the Micius Quantum Science Experimental Satellite have been in operation for approximately 2507 days and are still functioning properly, providing valuable experience for the future long-term space applications of silicon APD single-photon detectors.
Time transfer over 113 km free space laser communication channel
Authors: Cheng Yu-Xiang , Yang Meng , Lu Zhen-Jie , Tang Wen-Shuai , Guan Jian-Yu , Shen Qi , Yin Juan , Liao Sheng-Kai , Peng Cheng-Zhi
Published: March 2024

The space time frequency transfer plays a crucial role in applications such as space optical clock networks, navigation, satellite ranging, and space quantum communication. Here, we propose a high-precision space time frequency transfer and time synchronization scheme based on a simple intensity modulation/direct detection (IM/DD) laser communication system, which occupies a communication bandwidth of approximately 0.2%. Furthermore, utilizing an optical-frequency comb time frequency transfer system as an out-of-loop reference, experimental verification was conducted on a 113 km horizontal atmospheric link, with a long-term stability approximately 8.3 × 10−16 over a duration of 7800 seconds. Over an 11-hour period, the peak-to-peak wander is approximately 100 ps. Our work establishes the foundation of the time frequency transfer, based on the space laser communication channel, for future ground-to-space and inter-satellite links.
Research on the tool influence function characteristics of magnetorheological precession finishing (MRPF)
Authors: Liu Jiaming , Huang Peizhi , Peng Yunfeng
Published: March 2024

Magnetorheological finishing (MRF) technology is characterized by its high convergence rate and minimal subsurface damage as advantages. However, the non-Gaussian type tool influence function (TIF) it generates may cause mid-frequency errors and oriented surface texture issues. Magnetorheological precession finishing (MRPF) technology capable of generating Gaussian-like removal functions, lacks a clearly defined removal function model. This study acquired polishing spots in tilted polishing, discrete precession, and continuous precession modes via fixed-point polishing experiments. Using Multiphysics simulation software, stress and velocity distribution in the contact area were simulated. A TIF model, incorporating the synergistic effects of pressure and shear force and multiple influence coefficients, was proposed based on velocity characteristics across the three modes. To accurately predict the TIF, surface topographies with varying coefficients were constructed using this model, analyzing the coefficients’ impact on the TIF profile. Optimal coefficients were identified using a least fit error algorithm. Further analysis of the TIF's internal textures revealed that the precession mode of MRPF yields superior surface quality, thereby elucidating the material removal mechanism of MRPF and laying a theoretical groundwork for advancing processing technologies.
Simple few-shot method for spectrally resolving the wavefront of an ultrashort laser pulse
Authors: Smartsev Slava , Liberman Aaron , Andriyash Igor A. , Cavagna Antoine , Flacco Alessandro , Giaccaglia Camilla , Kaur Jaismeen , Monzac Joséphine , Tata Sheroy , Vernier Aline , Malka Victor , Lopez-Martens Rodrigo , Faure Jérôme
Published: March 2024

We present a novel, to the best of our knowledge, and straightforward approach for the spatio-spectral characterization of ultrashort pulses. This minimally intrusive method relies on placing a mask with specially arranged pinholes in the beam path before the focusing optic and retrieving the spectrally resolved laser wavefront from the speckle pattern produced at focus. We test the efficacy of this new method by accurately retrieving chromatic aberrations, such as pulse-front tilt (PFT), pulse-front curvature (PFC), and higher-order aberrations introduced by a spherical lens. The simplicity and scalability of this method, combined with its compatibility with single-shot operation, make it a strong complement to existing tools for high-intensity laser facilities.
Nonlinear error elimination using the fusion of PGC-DCM, geometric fitting, and Atan algorithms
Authors: Zhang Gang , Ge Qiang , Xu Linguang , Wu Xuqiang , Yu Benli
Published: March 2024

A phase generated carrier (PGC) demodulation scheme is always accompanied by nonlinear errors. We propose a fusion of PGC differential and cross multiplying (PGC-DCM), geometric fitting, and arctangent (Atan) algorithms for fiber optic interferometric sensors to eliminate nonlinear errors. The output amplitude of the PGC-DCM algorithm is used to judge whether the Lissajous figure of quadrature signals is larger than 1/2 ellipse arc. When the Lissajous figure exceeds 1/2 ellipse arc, the contaminated quadrature signals are corrected by the ellipse correction parameters calculated from the geometric fitting; otherwise, the previous fitting parameters are employed for correction. Geometric fitting is realized by minimizing the Sampson error, and its failure problem under small signals is solved by using the temporary stability of fitting results. Finally, desired signals are extracted from the corrected quadrature signals by the Atan algorithm. Experimental results show that the fusion combines the merits of the three algorithms and expands the application of the geometric fitting in PGC demodulation schemes.
Nonlinear-tolerant two-dimensional distribution matcher scheme for probabilistic shaping
Authors: Luo Yanan , Chen Bin , Huang Qin
Published: March 2024

This Letter proposes a nonlinear-tolerant two-dimensional distribution matcher (2D-DM) scheme. It removes the corner points of probabilistically shaped quadrature amplitude modulation (QAM) to obtain better nonlinear tolerance. Because the remaining number of points is not a power of 2, we propose to divide constellation points into different layers and symbols. Then, the proposed 2D-DM performs matching using one-dimensional shapers, which generates the in-phase and quadrature components of QAM together. In fact, it realizes two-dimensional shapers from one-dimensional shapers. Simulation results show that two-dimensional shapers generated by the proposed 2D-DM have higher tolerance to power amplifier nonlinearity and fiber nonlinearity compared to one-dimensional shapers.
Tm,Ho:YLF waveguide lasers at 2.05 µm
Authors: Bai Zichen , Chen Zhixiang , Xiong Yujie , Liu Hongliang , Gao Siying , Ren Yingying , Zhao Xingjuan , Liu Fengqin , Jia Yuechen , Chen Feng
Published: March 2024

In this work, we report on the first, to our knowledge, 2.05-µm laser based on femtosecond-laser direct written (FsLDW) Tm,Ho:YLF cladding waveguides. A channel waveguide with a 90-µm diameter “fiber-like” low-index cladding is fabricated in a 6 at. % Tm3+, 0.4 at. % Ho3+:LiYF4 crystal by FsLDW. Pumped by Ti:sapphire laser at 795.1 nm, the fabricated waveguide supports efficient lasing oscillation at 2050 nm with a maximum output power of 47.5 mW, a minimum lasing threshold of 181 mW, and a slope efficiency of 20.1%. The impacts of cavity conditions and polarizations of the pump light on the obtained lasing performance are well studied. The experimental results obtained in this study demonstrate the great potential of utilizing Tm,Ho:YLF and FsLDW for the development of durable mid-infrared lasers featuring compact designs.
Nanoprinted microstructure-assisted light incoupling into high-numerical aperture multimode fibers
Authors: Zeisberger Matthias , Schneidewind Henrik , Wieduwilt Torsten , Yermakov Oleh , Schmidt Markus A.
Published: March 2024

The coupling of light into optical fibers is limited by the numerical aperture (NA). Here, we show that large-area polymer axial-symmetric microstructures printed on silica multimode fibers improve their incoupling performance by two to three orders of magnitude beyond the numerical aperture limit. A ray-optical mathematical model describing the impact of the grating-assisted light coupling complements the experimental investigation. This study clearly demonstrates the improvement of incoupling performance by nanoprinting microstructures on fibers, opening new horizons, to the best of our knowledge, for multimode fiber applications in life sciences, quantum technologies, and “lab-on-fiber” devices.
Recommendations for measuring and standardizing light for laboratory mammals to improve welfare and reproducibility in animal research
Authors: Lucas Robert J. , Allen Annette E. , Brainard George C. , Brown Timothy M. , Dauchy Robert T. , Didikoglu Altug , Do Michael Tri H. , Gaskill Brianna N. , Hattar Samer , Hawkins Penny , Hut Roelof A. , McDowell Richard J. , Nelson Randy J. , Prins Jan-Bas , Schmidt Tiffany M. , Takahashi Joseph S. , Verma Vandana , Voikar Vootele , Wells Sara , Peirson Stuart N.
Published: March 2024

Light enables vision and exerts widespread effects on physiology and behavior, including regulating circadian rhythms, sleep, hormone synthesis, affective state, and cognitive processes. Appropriate lighting in animal facilities may support welfare and ensure that animals enter experiments in an appropriate physiological and behavioral state. Furthermore, proper consideration of light during experimentation is important both when it is explicitly employed as an independent variable and as a general feature of the environment. This Consensus View discusses metrics to use for the quantification of light appropriate for nonhuman mammals and their application to improve animal welfare and the quality of animal research. It provides methods for measuring these metrics, practical guidance for their implementation in husbandry and experimentation, and quantitative guidance on appropriate light exposure for laboratory mammals. The guidance provided has the potential to improve data quality and contribute to reduction and refinement, helping to ensure more ethical animal use.