bluuebunny/crossref_metadata_2025 huggingface dataset:
TICK SALIVA TOXINS, HOST IMMUNE RESPONSES AND ITS BIOLOGICAL EFFECTS
Authors: YADAV NIDHI , UPADHYAY RAVI KANT
Published: August 2021

Ticks are the most important ancient group of obligate blood-sucking ectoparasites of terrestrial vertebrates mainly of livestock. These small-sized animals are found in tropical and sub-tropical regions of the world. These act as vectors and transmit a wide range of protozoa, bacteria and viruses tick-borne diseases. These attach to host skin for blood-sucking and transmit disease pathogens through saliva. Ticks withdraw large volumes of blood from livestock and make them anemic and do significant weight loss. Ticks cause severe economic losses in livestock directly through blood-feeding and indirectly by transmitting protozoan, rickettsial and viral diseases This article highlights toxins/proteins secreted in tick saliva, and its important biological effects like anti-inflammatory, immunosuppressant peptide, and immunomodulatory and anti-chemokine activities. The present article clears host-pathogen interactions and invasion of a host by ticks, biological effects of tick saliva toxins and its host immune responses. These toxins could be used as immunoreactive proteins as a prerequisite for the development of specific and sensitive immunoassays for the determination of tick-borne illness. The authors suggest important management strategies for successful control of cattle, bird and canine ticks. This article also suggests tick control methods such as physical, chemical, hormonal and including prophylactic use of antibody and vaccine immune therapy.
EVALUATION OF ANTI-INFLAMMATORY ACTIVITY OF MACROALGAE COLLECTED FROM BAJA CALIFORNIA SUR, MEXICO
Authors: GARCÍA-LÓPEZ ELENA BERENICE , MUÑOZ-OCHOA MAURICIO , HERNÁNDEZ-GUERRERO CLAUDIA J. , NIETO-CAMACHO ANTONIO , BAND-SCHMIDT CHRISTINE J.
Published: August 2021

Objective: This study aimed to establish the anti-inflammatory potential of macroalgae from Baja California Sur, Mexico.
Methods: The anti-inflammatory activity of the extracts from 10 macroalgae species was evaluated in vitro and in vivo. Dichloromethane, ethanolic, and aqueous extracts were obtained from each species. The criteria used to determine anti-inflammatory activity included 1) the membrane protection of human red blood cells (HRBCs) against hemolysis induced by hypotonicity, 2) the inhibition of heat-induced protein denaturation (IDP), and 3) the inhibition of mouse ear edema and the myeloperoxidase (MPO) enzyme.
Results: The dichloromethane extracts of Gracilaria vermiculophylla and Opuntiella californica were the most active, both in vitro and in vivo. These extracts resulted in values of HRBC membrane protection above 95%, which were similar to those obtained with diclofenac sodium. And reduce the inflammation with edema inhibition percentage up to 60 % while the control indomethacin was able to inhibit edema by 82.3 %.
Conclusion: The bioprospection of several macroalgae species from Bahía de La Paz, Mexico, allowed the identification of two species with promising anti-inflammatory activity. Gracilaria vermiculophylla showed interesting topical anti-inflammatory effects and a profile of compounds (flavonoids and terpenes) that may contribute to the potential biological properties of this seaweed. This study represents the first report of the anti-inflammatory potential of O. californica.
EVALUATION OF ANTIBIOTIC EFFICACY AND PRESCRIBING PATTERN IN SKIN AND SKIN STRUCTURE INFECTIONS AT A TERTIARY CARE TEACHING HOSPITAL
Authors: FATHIMA NAZISH , M. SONIYA , THOMAS TANI ELSA , TIGI TEENA ELSA
Published: August 2021

Objective: This study was carried out to evaluate the efficacy and prescribing pattern of antibiotics in the skin and skin structure infections (SSTIs) at tertiary care teaching hospital.
Methods: In this prospective observational study, an attempt was made to evaluate the efficacy and prescribing pattern of antibiotics. Subjects were selected according to the inclusion and exclusion criteria and patient case sheets were analyzed for patient demographic details, results of physical examination and laboratory parameters, and prescription pattern.
Results: Cellulitis was the most common skin and skin structure infection among the subjects, followed by an ulcer. Few patients showed discomforts such as pain, swelling, and purulent discharge. Surgical procedure has been done in 76 patients. Out of 99 patients, 11 patients showed a prolonged length of stay (LOS) (≥16 d), which is an indication of the poor efficacy of antibiotics. Intravenous to oral antibiotic therapy switch was seen in 47 patients, which indicates that the patient’s condition was improved. The mean length of hospital stay was 8.79 d. The majority of patients have been discharged within 15 d. Cephalosporins were the most frequently prescribed class of antibiotics in patients with skin and soft tissue infections. Metronidazole was the most frequently used antibiotic as monotherapy followed by cefuroxime. Piperacillin+Tazobactam was the most frequently used combination antibiotic. This study finds that the antibiotic treatment was efficacious in the majority of the patients.
Conclusion: This study finds that the antibiotic treatment was efficacious in the majority of the patients.
MICROBIAL SYNTHESIS OF SILVER NANOPARTICLES USING STREPTOMYCES SP. PG12 AND THEIR CHARACTERIZATION, ANTIMICROBIAL ACTIVITY AND CYTOTOXICITY ASSESSMENT AGAINST HUMAN LUNG (A549) AND BREAST (MCF-7) CANCER CELL LINES
Authors: S. S. PALLAVI , BHAT MEGHASHYAMA PRABHAKARA , NAYAKA SREENIVASA
Published: August 2021

Objective: Synthesis of silver nanoparticles using Streptomyces sp. PG12 and their characterization, antimicrobial activity and cytotoxicity against A549 and MCF-7 cancer cell lines.
Methods: The silver nanoparticles were subjected to UV-Vis. spectroscopy, Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy with energy-dispersive X-ray spectroscopy (SEM/EDS), high-resolution transmission electron microscopy (HR-TEM), zeta potential, and X-ray diffractometry (XRD) analyses. Further, the antimicrobial potential was determined by using the agar well diffusion method and cytotoxicity was determined with the help of cell viability (MTT) assay and reactive oxygen species (ROS) assay.
Results: The initial indication of silver nanoparticles synthesis was noticed by the colour change in the reaction mixture and the absorption maximum at 421 nm in UV-Vis. analysis; whereas, the FTIR analysis displayed the biological functional groups responsible for the capping and stabilization of silver nanoparticles. SEM and TEM micrographs revealed the surface morphology, spherical shape, and smallest particle size as 18.91 nm. The EDS and XRD patterns confirmed the involvement of various elements during the synthesis of silver nanoparticles and the crystalline, face-centered cubic nature, respectively. The silver nanoparticles displayed considerable antimicrobial activity against human pathogens even at low MIC and MBC concentrations and exhibited increased anticancer activity against A549 and MCF-7 cell lines, where the ability of silver nanoparticles to significantly restrict the growth of tumour cells was observed at IC50 values of 69.04µg/ml and 138.30µg/ml, respectively.
Conclusion: Streptomyces sp. PG12 synthesized silver nanoparticles show significant anticancer activity against A549 and MCF-7 cell lines.
A la memoria de Guillermo Soberón, la figura más importante de la salud pública mexicana en el último medio siglo
Authors: Nigenda-López G.
Published: August 2021

Los sistemas de salud son los espacios institucionales que organizan un conjunto de recursos y capacidades para proveer la atención a la salud de la población que la demanda. Para lograr este objetivo, los sistemas de salud requieren que este conjunto de recursos y procesos estén perfectamente coordinados con el fin de generar los productos planteados.

El recurso más importante en un sistema de salud, es sin duda, el recurso humano. Mientras otros recursos con el tiempo se deprecian, el recurso humano gana valor al incrementar sus capacidades y la experiencia adquirida. La enfermería representa un recurso de gran valor en la producción de servicios a la salud. En la actualidad, las enfermeras se encuentran concentradas en ámbitos hospitalarios en función del modelo de atención prevalente en el sistema de salud mexicano. En un sistema de salud re-orientado hacia la atención primaria a la salud, la enfermería deberá adquirir mayor valor y relevancia a través de todo el sistema.
Tecnologías en la enseñanza en enfermería, innovación y uso de TICs: revisión integrativa
Authors: Araújo-Girão A.L. , Silva-Nunes Cavalcante M.L. , Costa-Lima de Oliveira I. , Freitas-Aires S. , Paz-de Oliveira S.K. , Fontenele-Lima de Carvalho R.E.
Published: August 2021

Introducción: La utilización de los recursos digitales modernos para la enseñanza constituye una estrategia para atender las nuevas necesidades de aprendizaje. En el ámbito de enfermería puede facilitar la inserción de los estudiantes en la práctica clínica en modo virtual para que desarrollen sus habilidades y competencias.

Objetivo: Analizar las evidencias sobre la utilización de tecnologías en la enseñanza de enfermería.

Métodos: Revisión integrativa realizada en el portal de revistas SciELO y en las bases de datos IBECS, LILACS, BDENF, Web of Science, PubMed y CINAHL.

Resultados: Se realizó la identificación inicial de 62 artículos, se aplicaron los criterios de exclusión hasta el establecimiento de la muestra de 26 artículos. Después de la lectura y análisis de los estudios, se constató que las tecnologías son más utilizadas junto con las clases teóricas en las aulas, o como plataformas online de enseñanza, o también como herramientas auxiliares para la práctica de simulaciones realísticas.

Discusión: El uso de internet fue predominante en los estudios, pues favorece la actualización, la comunicación y la cualificación académica. En cuanto a las plataformas digitales de enseñanza, el espacio virtual permite reunir e integrar diversos medios con finalidades diferentes posibilitando la creación de actividades variadas. Para la enseñanza a través de simulaciones se presentaron diversos beneficios de inmersión a un ambiente profesional desde la universidad.

Conclusiones: El estudio presenta una visión general de las tecnologías educativas utilizadas para la enseñanza de enfermería y provee conocimiento de nuevas metodologías, lo que beneficia a profesores y estudiantes.
Teoría de Kolcaba: propuesta para el cuidado de niños y niñas chilenos enfermos de cáncer
Authors: Delgado-Riffo C.A. , Valenzuela-Suazo S.
Published: August 2021

Introducción: La comodidad o bienestar es un concepto que ha estado presente como objetivo del cuidado de enfermería desde sus inicios como disciplina y ha demostrado ser un factor que mejora las condiciones de salud de las personas. Enfermería tiene la responsabilidad de entregar el mejor cuidado posible, fundamentando su quehacer en el conocimiento científico humanista y en el uso de teorías que emergen desde la disciplina. Dentro de éstas destacan por su aplicabilidad las teorías de rango medio, una de ellas es la teoría de la comodidad de Kolcaba, que ha sido utilizada en diversos contextos de salud. Por consiguiente, el presente artículo tiene como objetivo entregar una propuesta de aplicación de la teoría de la comodidad de Kolcaba para el cuidado de niños y niñas enfermos/as de cáncer en unidades pediátricas chilenas.

Desarrollo: Se realizó un análisis de los constructos que conforman la teoría, articulándolos con evidencias originadas desde su aplicación e integrándolos con la realidad que les toca enfrentar a los pacientes, sus familias y los equipos de salud oncológicos infantiles que también han sido documentadas.

Conclusión: Se presenta una propuesta de aplicación de la teoría de la comodidad en pacientes oncológicos pediátricos. De igual forma, se reconoce que esta teoría permite entregar un cuidado holístico al paciente y su familia.
Transferência de atenção pré-hospitalar entre equipes de saúde: revisão integrativa
Authors: Dalco-Miorin J. , Camponogara S. , Silva-de Mello T. , Petry K.E. , Bonfada-Torquetti A. , Loise-Dias G.
Published: August 2021

Introdução: As transferências de atenção efetivas permitem satisfazer as necessidades de continuidade do atendimento; porém, poucos estudos se centram em comunicar informação a esse respeito.

Objetivo: Analisar a evidência disponível na literatura sobre a transferência do atendimento pré-hospitalar entre equipes de saúde.

Metodologia: Revisão integrativa. A busca de estudos primários realizou-se em quatro bases de dados (PubMed, CINAHL, LILACS, Scopus). A amostra consistiu em 20 pesquisas, que se agruparam em duas categorias.

Resultados: A síntese da evidência apontou as estratégias empregadas pelas equipes de saúde para estandardizar a comunicação de informação durante a transferência da atenção pré-hospitalar e as circunstâncias que intervém neste momento. Dentre as estratégias salientamos o uso de um formulário de ambulância para utilizar nos serviços que continuarão o atendimento. Circunstâncias intermediárias incluem demoras na transferência e falhas na informação/comunicação.

Discussão. O uso de mnemônicos e protocolos para uma melhor transferência não é generalizado, mas existe consenso que a falta de processos de comunicação integrados contribui às falhas no atendimento.

Conclusão: As transferências efetivas de atendimento são complexas já que há vários fatores que interferem em seu processo, os quais dependem de negociações e acordos entre as equipes de saúde e os gestores.
Condición nutricional de escolares indígenas otomíes en situación de alta marginación
Authors: Regalado-Ruiz L.A. , Del-Ángel-Escalona A. , Ramos-Rodríguez R.M. , Vázquez-Arévalo R. , Mancilla-Díaz J.M.
Published: August 2021

Introducción: El panorama de la salud y nutrición de la población mexicana se enmarca en la conjunción de desnutrición crónica infantil, sobre todo en el medio rural e indígena, y el incremento significativo del sobrepeso y obesidad. Esta información proveniente de encuestas arroja resultados generalizados, sin considerar las particularidades del contexto biosociocultural en que viven comunidades indígenas, codeterminante de la condición nutricional de éstas.

Objetivo: Estudiar el estatus nutricional de un grupo de escolares de cultura otomí residentes en una comunidad de México en situación de marginación, considerando el contexto biosociocultural en el que viven.

Métodos: Estudio prospectivo transversal realizado en una localidad del Estado de México. Muestra por conveniencia constituida por 214 menores, entre 6 y 12 años de edad. Se emplearon técnicas antropométricas internacionalmente aceptadas para recabar la estatura y el peso, y se calculó el IMC. El estatus de nutrición se estimó con base en el peso, la estatura y el IMC para la edad y se compararon con los referentes de la OMS.

Resultados: La prevalencia de estatura baja para la edad y la desnutrición es menor, no así el sobrepeso/obesidad que afecta a un tercio de los menores. Solo para el IMC por edad y sexo hubo diferencias en ciertos grupos de edad. Las puntuaciones z de los tres indicadores son semejantes entre niños y niñas.

Discusión y Conclusiones: En comparación con los parámetros nacional y estatal, los menores estudiados muestran prevalencia menor de sobrepeso y obesidad asociado a su contexto sociocultural.
Mobility and feeding habits of semi-confined domestic pig groups in a rural locality endemic to cysticercosis
Authors: Martínez Pérez Mauricio , Villalobos Nelly , Morales Soto Julio , Rosetti Marcos , Sciutto Edda , Martínez Maya José Juan
Published: August 2021

Free-range pigs are in the highest risk to acquire cysticercosis in endemic rural locations, although the behavioral and physiological responses to the infection are known to vary widely between pigs. Those animals reared in semi-confinement showed a group behavior that allows us to follow the herd to assess the risks of contact with the parasite. This study is aimed to determine the movement and feeding habits of pig groups raised under semi-confinement conditions, using minimally invasive procedures, applying trajectory analysis to different herds in rural settings. Pig population and subpopulations were characterized, and their movement was evaluated in two seasons of the year, using a global positioning system (GPS). Our results indicate that pig groups are formed based on human ownership and the establishment of family bonds with each other. Each group interacts with other groups in specific sites of the village. Significant differences were found in the time and distance covered by pigs in the dry and rainy seasons (P < 0.05), and the distance travelled by different groups were found to take place in repetitive, well-defined spaces that include moving through sewage, landfills, and open defecation sites. Due to this stability, the trajectories covered by pigs could be useful as indicators of risk factors linked to the exposure of pigs to Taenia solium
Double Helical Spiral Mixer
Authors: Mosin. K Mr. Shaikh
Published: August 2021

Recently in advance mixer and blender designs have contributed to the growing success of food companies, meeting their requirement for consistency and developing new products, with lowering production costs. This paper discusses both traditional and new specialty mixing technologies available to food manufacturers today. Phases and viscosity are used to classify different mixing categories. Sample applications are presented as well to illustrate certain processing challenges and the mixing technologies used to resolve them. In conventional method of mixing the metal oxide powder and vehicle mixing is perform on ‘Unidirectional Stirring Machine’. The stirrer of conventional machine rotates in only one direction which creates a particular flow pattern in the fluids. Hence the particles tend to stick to the walls of container owing to the centrifugal force rather than mixing thoroughly in mixture of paint, ultimately results into poor quality mixture of paints there by poor quality output of paint.
Pembelajaran Sejarah Abad 21: Tantangan dan Peluang dalam Menghadapi Pandemi Covid-19
Authors: Absor Nur Fajar
Published: August 2021

Pandemi Covid-19 yang melanda dunia, termasuk Indonesia yang sudah berlangsung sekitar 6 bulan membuat sektor pendidikan melakukan pembelajaran secara daring. Hal ini menimbulkan permasalahan seperti kurang siapnya guru/dosen dalam menghadapi sistem pembelajaran daring serta guru/dosen yang memberikan banyak materi dan tugas kepada peserta didik/mahasiswa. Permasalahan tersebut juga menantang guru/dosen sejarah untuk membuat pembelajaran sejarah secara daring menjadi menarik. Tujuan dari penelitian ini adalah untuk menguraikan tantangan dan peluang yang dihadapi pembelajaran sejarah dalam menghadapi pandemi Covid-19. Penelitian ini menggunakan metode kualitatif dengan teknik pengumpulan datanya menggunakan instrumen studi dokumen atau dokumentasi. Hasilnya ditemukan bahwa terdapat peluang dalam melaksanakan pembelajaran sejarah secara daring, yakni guru/dosen dapat menggunakan Whatsapp, Facebook, Instagram, Google Classroom, Zoom, Google Meet, Youtube, Discord, dan tur virtual cagar budaya untuk menunjang pembelajaran daring. Selain itu, guru/dosen harus memasukkan pembelajaran sejarah yang juga berfokus kepada ranah afektif, sehingga tertanam nilai-nilai karakter yang dapat diinternalisasikan ke dalam kehidupan sehari-hari peserta didik/mahasiswa. Dengan demikian, diharapkan dengan adanya peluang-peluang yang diuraikan di atas dapat membuat pembelajaran sejarah lebih menarik lagi untuk dipelajari bagi peserta didik/mahasiswa.
Penerapan Model Pembelajaran PASA dalam Meningkatkan Motivasi Belajar pada Pembelajaran Sejarah Kelas X IPS 2 SMAN 1 Barru
Authors: Auliana Rezki , Patahuddin Patahuddin , Bustan Bustan
Published: August 2021

This study aims to analyze the application of the implementing the Picture and Student Active (PASA) learning model in increasing learning motivation of learning history in Class X IPS 2 SMAN 1 Barru. This research is a Classroom Action Research using qualitative and quantitative data analysis. This study shows that there are increases in students' historical learning motivation after apply PASA learning model, namely in Cycle I it shows that the average score of students' learning motivation is 67.47% which is in the medium category, while in Cycle II shows the average score of students' learning motivation of 80.88% which is in the high category. So, it can be concluded that the application of the PASA learning model can increase the learning motivation of Class X IPS 2 SMAN 1 Barru students.

 

Abstrak

Penelitian ini bertujuan untuk menganalisis penerapan model pembelajaran Picture and Student Active (PASA) dalam meningkatkan motivasi belajar pada pembelajaran sejarah Kelas X IPS 2 SMAN 1 Barru. Penelitian ini adalah Penelitian Tindakan Kelas menggunakan analisis data kualitatif dan kuantitatif. Penelitian ini menunjukkan bahwa terjadi peningkatan motivasi belajar sejarah peserta didik setelah menerapkan model pembelajaran PASA, yaitu pada Siklus I menunjukkan bahwa skor rata-rata motivasi belajar peserta didik sebesar 67,47% yang berada pada kategori sedang, sedangkan pada Siklus II menunjukkan skor rata-rata motivasi belajar peserta didik sebesar 80,88% yang berada pada kategori tinggi. Maka, dapat disimpulkan bahwa penerapan model pembelajaran PASA dapat meningkatkan motivasi belajar peserta didik Kelas X IPS 2 SMAN 1 Barru.
Causal influence in operational probabilistic theories
Authors: Perinotti Paolo
Published: August 2021

We study the relation of causal influence between input systems of a reversible evolution and its output systems, in the context of operational probabilistic theories. We analyse two different definitions that are borrowed from the literature on quantum theory—where they are equivalent. One is the notion based on signalling, and the other one is the notion used to define the neighbourhood of a cell in a quantum cellular automaton. The latter definition, that we adopt in the general scenario, turns out to be strictly weaker than the former: it is possible for a system to have causal influence on another one without signalling to it. Remarkably, the counterexample comes from classical theory, where the proposed notion of causal influence determines a redefinition of the neighbourhood of a cell in cellular automata. We stress that, according to our definition, it is impossible anyway to have causal influence in the absence of an interaction, e.g. in a Bell-like scenario. We study various conditions for causal influence, and introduce the feature that we call no interaction without disturbance, under which we prove that signalling and causal influence coincide. The proposed definition has interesting consequences on the analysis of causal networks, and leads to a revision of the notion of neighbourhood for classical cellular automata, clarifying a puzzle regarding their quantisation that apparently makes the neighbourhood larger than the original one.
Self-referenced hologram of a single photon beam
Authors: Szadowiak Wiktor , Kundu Sanjukta , Szuniewicz Jerzy , Lapkiewicz Radek
Published: August 2021

Quantitative characterization of the spatial structure of single photons is essential for free-space quantum communication and quantum imaging. We introduce an interferometric technique that enables the complete characterization of a two-dimensional probability amplitude of a single photon. Importantly, in contrast to methods that use a reference photon for the phase measurement, our technique relies on a single photon interfering with itself. Our setup comprises of a heralded single-photon source with an unknown spatial phase and a modified Mach-Zehnder interferometer with a spatial filter in one of its arms. The spatial filter removes the unknown spatial phase and the filtered beam interferes with the unaltered beam passing through the other arm of the interferometer. We experimentally confirm the feasibility of our technique by reconstructing the spatial phase of heralded single photons using the lowest order interference fringes. This technique can be applied to the characterization of arbitrary pure spatial states of single photons.
Systematic approach to creative personnel management: effective way to innovation
Authors:   the Pyatigorsk State University, Salogub A. M.
Published: August 2021

The main trends in the field of creative personnel management and the value of innovative culture were the subject of the study. Creative staff and innovation culture are of particular importance due to the need of organization to increase competitive advantages through the development of its innovative potential. The purpose of the work was to analyze trends in the personnel management and study modern approaches to the management of creative personnel, providing the organization with growth, development and innovation. The results of the work: the concepts of creativity, innovation, competitive advantage, organization of an innovative type were investigated and specified, key trends in the HR sphere (in human resource management) were summarized, the roles of personnel managers were understood. The profile of employees of generation Z has been investigated, the logic of motives for the behavior of creative employees has been built. Characteristics of innovative culture based on reproduction of the startup culture values are given. Successful startups (creative teams) are able to optimally combine experimentation, risk and responsibility. It was concluded that the ability to think creatively is a universal human talent. Practical recommendations on HR analytics and the effectiveness of personnel decisions are presented, key directions of the strategy for managing the younger generation Z are specified, the motives for behavior of creative employees are investigated, characteristics of innovative culture that allow the organization built a creative environment are studied.
The impact of coronavirus epidemic on trade and economic cooperation of the Heilongjiang province with Russia and measures to restore it
Authors:   the Institute of Russia of the Heilongjiang Academy of Social Sciences, Mei Zhang
Published: August 2021

The article presents a brief overview of the state of Sino-Russian trade and economic cooperation in the context of the pandemic of coronavirus infection that has swept the whole world. On the example of regional cooperation between the Heilongjiang Province (PRC) and Russia, it is shown that under the influence of coronavirus epidemic, trade turnover decreased, while Russia retained the position of the main trading partner of the Heilongjiang Province. The results and prospects for the operation of the Heilongjiang Province free trade pilot zone are shown. The author presents characteristics of the measures taken by the province and aimed at the restoration and development of the Russian-Chinese trade and economic cooperation. Among them, in particular, measures of anti-epidemiological, institutional and infrastructural nature are highlighted; examples of positive results of these measures are shown.
Reactive social and political interactions in innovation processes in the Russian regions
Authors:   the Kemerovo State University, Kranzeeva E. A. , Golovatskiy E. V. ,   the Kemerovo State University, Orlova A. V. ,   the Kemerovo State University, Nyatina N. V. ,   the Kemerovo State University, Burmakina A. L. ,   the Kemerovo State University
Published: August 2021

The article deals with social and political interactions between the population and the authorities. Modern conditions have transferred a significant part of interactions into a virtual environment, which forms new reactive forms of communication between the authorities and the population. The innovative processes taking place in the regions should reflect not only the institutionally set priority directions of development, but also the interests and requests initiated by the local population, and this enhances the reactive nature of interaction. The purpose of the article is to analyze the reactivity of social and political interactions between the authorities and the population in the context of the innovative development of regions (federal districts) of the Russian Federation. The authors analyzed two digital platforms: the Russian Public Initiative (www.roi.ru) and Change.org (www.change.org). They highlighted the topical thematic areas of social initiatives and political petitions in the federal districts and outlined the transformation of social and political interactions in the formation of directions for the implementation of open innovations in the regions of the Russian Federation. As a result of the study, the authors came to the conclusion about the coincidence of the topics of the population's requests and the implemented purposeful state strategic project activities, expressed in national projects. In the context of digitalization, the population builds socio-political interactions in the channels and communication tools set by the authorities, and also gets the opportunity to carry out parallel network and cloud communications, which make it possible to form new spaces for interaction with authorities in the country and specific regions. Civic activism and participation in innovation processes are demonstrated by: the growth of digital presence; participation of citizens in the network and «cloud» (including self-organizing) communities; formation of a network environment for discussion and methods of digital interaction with the government institutions in the regions.
Earnings management, corporate governance, and ownership structure of Philippine initial public offerings
Authors: Burdeos Angelo O.
Published: August 2021

Prior studies examined the effect of corporate governance variables on discretionary current accrual, the most widely used measurement of earnings management. The principal-agent conflict implies that the size of the board, the percent of independent directors, CEO duality, and auditor prestige limit discretionary current accruals (DCA). This paper extends past studies by examining the effect of ownership structure on discretionary current accruals. The study determines the level of income-increasing earnings management of initial public offerings (IPOs) in the Philippines and the factors that explain it. Particularly, the paper examines the effect of ownership concentration and largest shareholder ownership on discretionary current accruals. The study uses a final sample of 105 IPO firms in Philippine Stock Exchange (PSE) from 2008 to 2018. Employing the modified Jones’s (1991) model to measure discretionary current accrual and multiple regression analysis, the study finds -4.19% discretionary current accrual on the average. It also reveals that the 2002 Philippine Code of Corporate Governance (PCCG) is ineffective in curbing earnings management. In addition, there is an insignificant relationship between the size of the board, CEO duality, ownership concentration, largest shareholder ownership and auditor prestige, and earnings management. Furthermore, the paper finds a significant relationship between the percent of independent directors, industry sector, return on assets (ROA) and cash flow from operations and earnings management.
Blow up for the solutions of the pressureless Euler-Poisson equations with time-dependent damping
Authors: Liu Jianli , Wang Jingwei , Tong Lining
Published: August 2021

The Euler-Poisson equations can be used to describe the important
physical phenomena in many areas, such as semiconductor modeling and
plasma physics. In this paper, we show the singularity formation
mechanism for the solutions of the pressureless Euler-Poisson equations
with time-dependent damping for the attractive forces in R^n (n ≧1)
and the repulsive forces in R. We obtain the blow up of the derivative
of the velocity under the appropriate assumptions.
DETERMINATION OF THORACIC COMPUTERIZED TOMOGRAPHY FINDINGS IN COVID-19 CASES BY DEEP LEARNING
Authors: Sumer Sua , Ural Onur , Ural Asli , DEMİR NAZLIM AKTUĞ , Cebeci Hakan , Kilincer Abidin , Kanat Fikret , Uslu Ediz , Koplay Mustafa , Demir Lutfi Saltuk , Arslan Ugur , Seher Nusret
Published: August 2021

Aims: The effects of the COVID-19 pandemic continue around the world.
Imaging methods play an important role in the diagnosis of COVID-19. The
aim of this study was to develop a system that would allow for the
distinguishing of lesions at different stages of the disease based on
similar signs of other viral diseases and monitoring the emergence,
progression, and/or remission of lesions in different areas of the
lungs. Methods: For the deep learning (DL) system, the thoracic CT
images from 1,382 images were reviewed. These belonged to patients whose
SARS-CoV-2 RT-PCR tests turned out positive, were diagnosed with
COVID-19, and had signs of lung involvement. Of 1,382 images in the
dataset, 180 were assigned for testing and 1,202 were assigned for
training. Apart from our dataset, 131 images for internal testing and
1,365 images for external testing were used. The trainings were
continued to cover 316,000 steps. Results: Internal and external
analyses were used to assess the developed model. The internal analysis
success rate was 93.12%. For first external analysis we used 85 images.
In the first external analysis we assessed a single CT image of each
patient who was in the mixed image lists, and the success rate was found
to be 70.31%. In the second external analysis, 645 thoracic CT images
of patients diagnosed with COVID-19 and 635 images of another patients
who had signs of non-COVID-19 diseases were used. We assessed the
thoracic CT images with both COVID-19 and non-COVID-19 disease signs.
The success rate in the identification of COVID-19 patients was 88.4%.
Conclusion: Special modeling systems developed using DL may help
accelerate workflow and making the process easier. This is especially
important in cases in which fast and accurate assessment is essential
for of a large number of patients, as happens in a pandemic.
Actividad antioxidante y contenido de polifenoles en pulpa del caimo (Pouteria caimito)
Authors: Aguilera Agudelo Lina Marcela , Hernández León Nicole Dayanna , Ramírez Niño Miguel Angel , Navarro Ramírez Miguel Ángel
Published: August 2021

El caimo (Pouteria caimito), es un fruto nativo de la Amazonia, de característica comestible, dulce y apetecible en su estado natural. Además, es una de las frutas tropicales con grandes posibilidades de explotación, pero sus estudios son limitados y la planta aún se encuentra en condiciones silvestres. Este fruto al ser cortado y expuesto al ambiente se oxida rápidamente dificultando su comercialización, por esta razón con el fin de un futuro aprovechamiento agroindustrial; se tuvo como objetivo la cuantificación de polifenoles totales mediante el método colorimétrico Folin Ciocalteu y la determinación de la actividad antioxidante por medio del radical 2, 2-difenil-i-picrilhidrazilo (DPPH) en pulpa de caimo fresca y liofilizada empleando dos disolventes etanol y metanol, además se compararon los valores obtenidos con otras frutas conocidas por su alto poder antioxidante reportadas en la literatura. Los resultados se llevaron al software Minitab versión 16.0 arrojando resultados con diferencias estadísticamente significativas (P<0.05) indicando una homogeneidad sobresaliente en cada una de las muestras. El extracto con mayor contenido de polifenoles totales para pulpa de caimo fresco fue etanol con un 92.41 ± 17.42 mg AG/100 g de pulpa y para pulpa de caimo liofilizado fue metanol con un 506.06 ± 20.7 mg AG/100 g de pulpa, para los resultados de actividad antioxidante se determinó el porcentaje de inhibición del radical libre (DPPH) y la concentración media inhibitoria (IC50) los cuales son inversamente proporcionales. El extracto que presento mayor poder antioxidante en pulpa de caimo fresco fue etanol con un 42.85% con un IC50 de 3.84 mg/ml y para pulpa de caimo liofilizado fue metanol de 77.51% con un IC50 de 0.65 mg/ml; de los resultados obtenidos se determinó que el extracto y tratamiento que presenta mayor contenido de polifenoles y capacidad antioxidante fue el extracto pulpa de caimo liofilizada con metanol.
Efecto del flushing sobre el desempeño reproductivo en ovejas de pelo en un centro de apoyo a la investigación y docencia en México
Authors: Gonzales Garzón Andrea Carolina , Góngora Orjuela Agustín , Sánchez Gallegos Jaime
Published: August 2021

La producción ovina es un renglón importante de la economía pecuaria en México, la cual puede ser mejorada con la implementación de estrategias nutricionales y biotecnológicas. Este estudio evaluó el efecto del flushing en ovejas con condición corporal media (CCM) o baja (CCB) sobre el desempeño reproductivo en un centro de apoyo a la investigación y docencia en México. Se seleccionó un grupo de 42 ovejas multíparas de razas Pelibuey, Dorper, Hampshire, East friesian y Damara asignadas a 4 tratamientos T1: (N = 10 CCM con T2:  CCB¿=)(/^*ÑCA) y Baja (CCB)peci en Mexico-Ceisaflushing), T2: (N = 9 CCM sin flushing), T3: (N = 12 CCB con flushing), T4: (N = 11 CCB sin flushing). El flushing consistió en una dieta basada en sorgo (proteína cruda: 14.76), se realizaron pesajes (antes, durante y después del experimento). Se sincronizaron con un CIDR®, con retiro al día 9 y detectado el estro y monta natural inmediata. Al día 7 se aplicó 1 mL de Lutalyse® (7.5 mg PGF2α). Se evaluó la tasa de ovulación y gestación por ultrasonografía al día 45 y 75, igualmente se midió la prolificidad y fecundidad. Las medias de los pesajes fueron: antes de flushing T1: 49.08; T2: 49.15; T3: 54.46 y T4: 52.43, durante flushing T1: 48.12; T2: 47.08; T3: 55.06 y T4: 50.56 y post flushing T1: 49.42; T2: 49.11; T3: 55.00 y T4: 53.63. Las medias totales para los 3 pesajes fueron P1 = 51.28; P2 = 50.21; P3 = 51.79. En cuanto a las variables reproductivas no se encontraron diferencias estadísticamente significativas por medio de una prueba de Z; sin embargo las proporciones de los datos obtenidos muestran diferencias entre tratamientos, como los son: en la presentación del estro de los T1, T3 y T4 (90, 100 y 90.4% respectivamente) frente al T2 (55.5%); en la gestación el T1 (60%) frente a T2, T3 y T4 (44.4, 41.7 y 10% respectivamente) y respecto a la prolificidad los T1, T3 y T4 tuvieron un mayor número de crías/oveja (0.80; 1.00 y 0.90 respectivamente) respecto al T2 (0.33). El uso del flushing en animales con CCB antes de la monta o durante la sincronización con métodos farmacológicos mejora la fertilidad; pero es importante seguir supliendo los requerimientos de proteína para mejorar la fecundidad, disminuir las muertes neonatales y mejorar el peso al nacimiento de los borregos.
Implementación de buenas prácticas en alimentación bovina en la granja del colegio del Municipio de El Dorado Meta
Authors: Bernal Lizarazo Johan Sebastián , Fernández Manrique José
Published: August 2021

Debido al conflicto armado en algunas de nuestras regiones, era imposible trabajar algunas zonas rurales con un alto potencial para un sistema de producción bovina, el objetivo de este proyecto fue promover a los campesinos, productores, docentes y jóvenes de la región del Dorado en el fortalecimiento del sector rural, mediante la implementación de las buenas prácticas en alimentación bovina con la ganadería de la Institución Educativa El Dorado, se tomaron seis muestras de sangre y seis muestras de material fecal de los animales, se tomaron muestras de suelo en los potreros de la granja para análisis físico-químico, Muestras de agua donde consumían los animales para análisis físico-químico y microbiológico. Las variables se analizaron mediante la estadística descriptiva. Al examen clínico, se encontró condición corporal en promedio de 3, infestación marcada de ectoparásitos (Garrapatas y miasis). En el análisis de los cuadros hemáticos se evidencio 5 animales con aumento en la concentración de hemoglobina corpuscular media, 2 animales con leucocitosis y linfocitosis, 4 animales con eosinofilia. En la química sanguínea todos los animales presentaron glucosa baja, globulinas altas, además se encontró variación en la relación Ca-P. En el coprológico 3 animales presentaron anaplasmosis. El agua presento anormalidades en los parámetros microbiológicos. Los suelos son oxisoles, francos arenosos, con deficiencias en materia orgánica, pH y nitrógenos totales. Mejorando la calidad del agua y del suelo podemos tener mejores pastos. Mejorando la sanidad mayor aprovechamiento de los alimentos, para luego aplicar estrategias que mejoren la producción de forraje verde, establecimiento correcto de praderas mejoradas, uso adecuado de abonos y fertilizantes, adecuada rotación de potreros, y el establecimiento de métodos de conservación de forrajes como el ensilaje y el heno.
Pancreatic Differentiation of Stem Cells Reveals Pathogenesis of a Syndrome of Ketosis-Prone Diabetes
Authors: Yang Diane , Patel Sanjeet , Szlachcic Wojciech J. , Chmielowiec Jolanta , Scaduto Diane , Putluri Nagireddy , Sreekumar Arun , Suliburk James , Metzker Michael , Balasubramanyam Ashok , Borowiak Malgorzata
Published: August 2021

Genetic analysis of an adult patient with an
unusual course of Ketosis-Prone Diabetes (KPD) and lacking islet autoantibodies
demonstrated a nucleotide variant in the 5’-UTR of PDX1, a beta-cell development gene. When differentiated to
the pancreatic lineage, his induced pluripotent stem cells stalled at the
definitive endoderm stage. Metabolomic analysis of the cells revealed that this
was associated with leucine hypersensitivity during transition from the
definitive endoderm to the pancreatic progenitor stage, and RNA-sequencing
showed defects in leucine-sensitive mTOR pathways contribute to the
differentiation deficiency. CRISPR-Cas9 manipulation of the PDX1 variant demonstrated that it is
necessary and sufficient to confer leucine sensitivity and the differentiation
block, likely due to disruption of binding of the transcriptional regulator NFY
to the PDX1 5’-UTR, leading to
decreased PDX1 expression at the early pancreatic progenitor stage. Thus, the
combination of an underlying defect in leucine catabolism characteristic of KPD
with a functionally relevant heterozygous variant in a critical beta-cell gene
that confers increased leucine sensitivity and inhibits endocrine cell
differentiation resulted in the phenotype of late-onset beta-cell failure in this
patient. We define the molecular pathogenesis of a diabetes syndrome and
demonstrate the power of multi-omics analysis of patient-specific stem cells
for clinical discovery.
MULHERES NA POLÍTICA NACIONAL:REPRESENTATIVIDADE NO SENADO FEDERAL
Authors: Munhoz Claudia Costa , Oliveira Viviane de Arruda Pessoa
Published: August 2021

Este trabalho versa sobre a representatividade das mulheres brasileiras em locais de poder, com foco no Senado Federal e as ações afirmativas utilizadas para a mudança desse cenário. Foram utilizados dados, legislações e referências bibliográficas, para seu desenvolvimento. Tem por objetivo analisar a falta de representatividade feminina em nosso país, passando por um contexto histórico nacional e mundial, visando demonstrar assim as origens dos direitos das mulheres como grupo social específico. Em seguida, analisamos as ações que o Estado Brasileiro toma para buscar a igualdade entre os gêneros em nossa sociedade e sua eficácia, demonstrando as dificuldades sociais enfrentadas pelas mulheres e posteriormente as dificuldades políticas encontradas por este grupo social em locais de poder. Por fim analisamos o conceito de representatividade e seus benefícios e trazemos exemplos algumas mulheres que encontram-se em locais de poder e que colaboraram com leis para seu grupo social.
LIBERDADE DE EXPRESSÃO EM PERÍODO ELEITORAL: RESTRIÇÕES SÃO ADMITIDAS PELA CONSTITUIÇÃO FEDERAL?
Authors: Cunha Tais Macedo de Brito
Published: August 2021

O presente trabalho tem por objetivo analisar a liberdade de expressão no contexto do período eleitoral, tendo como referencial o julgamento da ADI 4451, que levou o tema à apreciação do Supremo Tribunal Federal. A pesquisa é documental e adota abordagem dedutiva, identificando as premissas fixadas no julgado do STF para indicar as orientações para as próximas eleições. Sem deixar de reconhecer a possibilidade de restrições necessárias à higidez do processo eleitoral, a exemplo da vedação da propaganda política, o julgado segue de forma coerente a jurisprudência da corte constitucional, reconhecendo que restrições à liberdade de expressão são excepcionais. Nesta linha, reconhece a desproporcionalidade das restrições impostas no art. 45, incisos II e III (segunda parte),   da Lei das Eleições ( Lei 9.504/1997).  Ainda que em sede de obiter dictum, o fenômeno das fakes news é tangenciado no julgamento, que reconhece a liberdade de imprensa como instrumento importante para o combate deste fenômeno pernicioso ao regime democrático. A abordagem é original na medida em que insere na análise do julgamento debates atuais sobre o tema das fakes News, ganhando destaque a importância do enfrentamento do tema diante da proximidade das eleições municipais.
The hemodynamic impact of the bidirectional flow within calf perforators and conductive veins in varicose vein disease
Authors: Recek Cestmir
Published: August 2021

The hemodynamic assessment of the bidirectional flow within calf perforators and in the conductive veins in varicose vein disease is presented. The bidirectional streaming within calf perforators is induced by the changing polarity of the systolic and diastolic pressure gradients arising during calf pump activity between the deep veins and the saphenous system of the lower leg, as documented by simultaneous pressure measurements in the posterior tibial vein and the great saphenous vein. This bidirectional flow makes the deep and superficial veins of the lower leg conjoined vessels. The vector of the bidirectional streaming in varicose vein patients is oriented inward, into the deep veins. The enlarged calf perforators are the consequence of the saphenous reflux; after elimination of saphenous reflux the diameter of calf perforators diminishes significantly. Results of venous pressure, plethysmographic and electromagnetic flow measurements rebut the still prevalent opinion that the outward flow within calf perforators is a reflux. There is an up-and-down flow in the conductive veins during calf pump activity with a prevailing systolic centripetal (orthograde) flow in the popliteal/femoral axis and a diastolic centrifugal (retrograde) flow in the incompetent great saphenous vein. The popliteal vein represents actually the drain pipe of the calf muscle pump. The ambulatory venous pressure gradient arising during the diastolic phase of the calf pump activity resembles the diastolic pressure difference between the aorta and the left ventricle.
Studi Tentang Proses Pengembangan Koleksi pada Perpustakaan STITMA Yogyakarta
Authors: Dahlia Nining
Published: August 2021

Penulisan ini bertujuan untuk meneliti proses pengembangan koleksi pada perpustakaan STITMA Yogyakarta. Metode yang dgunakan yaitu menggunakan metode observasi, dan wawancara. Observasi merupakan cara pengumpulan data dengan melakukan pengamatan secara langsung. Wawancara merupakan cara pengumpulan data dengan cara tanya jawab dengan pustakawan. Objek yang menjadi kajian dalam penelitian ini yaitu proses atau tahapan dalam kegiatan pengembangan koleksi yang dilaksanakan perpustakaan. Wawancara dilakukan dengan karyawan yang mengurus perpustakaan dan penulis sendiri juga terjun langsung selama dua bulan bekerja di instansi tersebut. Hail dari penelitian ini adalah pada proses pengembangan koleksi di perpustakaan STITMA Yogyakarta dari 7 proses pengembangan koleksi hanya melakukan empat tahapan dari empat tahapan secara umum. Empat tahapan tersebut antara lain yaitu melakukan analisis masyarakat pengguna, seleksi bahan pustaka, pengadaan bahan pustaka, dan penyiangan bahan bahan pustaka.