bluuebunny/crossref_metadata_2025 huggingface dataset:
Proposed Marketing Strategy to Improve Mutual Fund Asset under Management (AUM) Growth of PT. Anargya Aset Management
Authors:   Department of Business Administration, ITB, Bandung, Indonesia, Alamsyah Reggy Aldynov , Fachira Ira ,   Department of Business Administration, ITB, Bandung, Indonesia
Published: August 2023

People frequently use the asset under management (AUM) of investment management companies as a key indicator when evaluating their investment options. Anargya AUM is not competitive enough, ranking 72 from 95 investment managers in Indonesia. Anargya feels the need to prioritise increasing their AUM in order to capture leads so it can be converted into sales. Anargya needs to evaluate their marketing strategy to increase brand awareness, in hope to increase their mutual funds AUM. The author will then examine the marketing mix (7P) and lastly SWOT/TOWS matrix was developed before coming up with a marketing communication strategy that is appropriate for the research object. Mediocre marketing strategy can hinder the company’s ability to be presence both in physical and digital. Anargya not prepared enough to communicate its brand message. This investment management company can overcome the challenges and improve their marketing strategy and social media presence, leading to enhanced brand awareness
Pityriasis Rosea of Gibert: A Comprehensive Review of a Common, Self-Limiting Dermatologic Entity
Authors:   Hospital “Chiapas nos une” “Dr. Jesús Gilberto Gómez Maza”, Tuxtla Gutiérrez, Chiapas, México., Ramos Monserrat Espinosa , Guevara Maria Reyna Lara ,   Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado, Clínica hospital Irapuato, Guanajuato, México., Tenorio Salmahk Karen Avilés ,   Instituto Mexicano del Seguro Social. Hospital General de Zona 14 La Paz. Guadalajara, Jalisco, México.
Published: August 2023

Pityriasis rosea of Gibert is a common, self-limiting dermatologic entity that continues to raise questions regarding its etiology, diagnosis, and clinical management. This comprehensive review focuses on analyzing the distinctive clinical presentation of pityriasis rosea, characterized by the appearance of a herald patch followed by multiple secondary collarete or Christmas tree lesions. Although the exact cause of this disease remains unknown, a possible relationship with an immune reaction triggered by a previous viral infection or environmental factors yet to be identified is postulated. Through a thorough literature search, current findings on the epidemiology, pathogenesis and clinical diagnosis of pityriasis rosea are evaluated. The importance of the clinician's clinical judgment and accurate identification of the distinctive features of the skin lesions to reach an accurate diagnosis is emphasized. Although pityriasis rosea is usually asymptomatic or causes mild pruritus in most cases, symptomatic therapeutic options, such as the use of oral antihistamines and low potency topical corticosteroids, are described to alleviate patient discomfort when necessary. Patient education and psychological support are essential to decrease the anxiety associated with skin lesions and to provide reassurance during the self-limiting course of this condition. In the context of the clinical and epidemiologic relevance of pityriasis rosea, the need for continued research to improve understanding of its etiology and management arises. Although pityriasis rosea does not represent a serious health threat, its high frequency in the population and its distinctive clinical appearance underscore the importance of empathetic and compassionate medical care to ensure the patient's well-being during the process of spontaneous resolution.
The Effect of Media Exposure, Environmental Performance, and ISO 14001 Certification on Carbon Emission Disclosure
Authors:   Faculty of Economics and Business, Universitas Trisakti (Fakultas Ekonomi dan Bisnis, Universitas Trisakti), Mita Sari Nia , Sulfitri Virna ,   Faculty of Economics and Business, Universitas Trisakti (Fakultas Ekonomi dan Bisnis, Universitas Trisakti)
Published: August 2023

Climate change is increasingly having a negative impact on people’s lives as well as the environment. Various diseases related to ambient air pollution are increasingly becoming the cause of death. Natural disasters also occur frequently, causing huge losses. Greenhouse gas emissions, often called carbon emissions, are one of the biggest causes of climate change. This research aims to provide empirical evidence regarding the effect of media exposure, environmental performance, and ISO 14001 certification on carbon emission disclosure. Research data were obtained from the Indonesia Stock Exchange website, the PROPER Secretariat website of the Ministry of Environment and Forestry in the Republic of Indonesia, and corporate media covering nonfinancial companies (energy, industry, basic materials, transportation and logistics). The research sample selection used purposive sampling, resulting in 95 unbalanced data for three years (2019-2021). This research uses panel data regression analysis to examine the effect of media exposure, environmental performance, and ISO 14001 certification on carbon emission disclosure. The results showed that media exposure and environmental performance positively affect carbon emission disclosure. Meanwhile, ISO 14001 certification has no effect on carbon emission disclosure.
Cientistas são mesmo necessários?
Authors: Manzoni-de-Almeida Daniel
Published: August 2023

A crítica à Ciência, e seus mecanismos de poderes, foi um dos temas centrais na obra A vida de Galileu, de Bertold Brecht. Desde 2019 venho apresentando um trabalho autoetnográfico, em diversas facetas, com a obra A vida de Galileu por meio da construção de diários de leitura. Apresento aqui uma terceira parte dessa investigação autoetnográfica que consiste na construção do diário de leitura que realizei pós-defesa da tese de doutoramento em teoria literária, que, na ocasião, teve foco na experiência de um pesquisador em meio à pandemia da COVID-19 no cenário político brasileiro de 2020-2021, e agora o diário versa sobre a experiência de um pesquisador no exterior, em um mundo que se considera pós-pandemia da COVID-19 e diante das consequências da guerra da Ucrânia.
Public Intention on Bandung Tour on Bus
Authors: Anwar Tezza Adriansyah , Puspita Yessy
Published: August 2023

Bandung dikenal sebagai ibu kota Jawa Barat. Bandung berkembang juga sebagai kota kuliner. Sebagai bentuk tanggung jawab Pemerintah untuk memfasilitasi wisatawan yang datang ke Bandung, Pemerintah secara resmi mengumumkan Bus Pariwisata "Bandros" (Bandung Tour on Bus). Namun secara praktis, banyak masalah yang dihadapi oleh para pemangku kepentingan. Standarisasi harga di antara penumpang, batasan jumlah bus yang tidak dapat melayani penumpang, ketidakjelasan rute termasuk keberangkatan dan kedatangan, manajemen yang tidak sehat untuk faktor keselamatan dan meningkatnya jumlah penumpang yang memberikan dampak negatif karena kualitas layanan. Tujuan dari penelitian ini adalah untuk mendeskripsikan kualitas layanan, kepuasan masyarakat dan minat masyarakat untuk menggunakan kembali Bandros, dan juga untuk mendapatkan hasil analisis sejauh mana kualitas layanan berpengaruh terhadap kepuasan masyarakat serta dampaknya terhadap minat masyarakat untuk menggunakan kembali Bus Bandros. Dalam penelitian ini, peneliti menggunakan metode deskriptif-verifikasi. Metode ini digunakan untuk memverifikasi kualitas layanan persepsi, kepuasan masyarakat dan niat masyarakat untuk menggunakan kembali Bus Bandros dengan melibatkan 500 responden yang ingin menggunakan Bus Bandros. Penyebaran dan pemilihan responden dilakukan dengan menggunakan convenience sampling. Analisis jalur juga digunakan dalam penelitian ini. Berdasarkan hasil proses pengujian statistik ditemukan persepsi yang signifikan antara variabel kualitas layanan dan citra merek dengan minat masyarakat di Kota Bandung untuk menggunakan Bus Bandros. Untuk rekomendasi dalam penelitian ini, kejelasan informasi dapat meningkatkan niat publik untuk menggunakan Bus Bandros, karena informasi yang disampaikan akan memberikan kejelasan dalam rangka meningkatkan niat publik untuk naik Bus Bandros.
Sistem Presensi Mahasiswa Berbasis QR Code di STMIK “AMIKBANDUNG”
Authors: Rafila Amal Julio , Darmanto Tedjo , Kurniawan Rudi
Published: August 2023

Salah satu hal penting yang perlu diperhatikan dalam penilaian mahasiswa adalah masalah presensi mahasiswa. Proses presensi mahasiswa yang sudah sangat umum dilakukan oleh perguruan tinggi adalah pencatatan presensi secara manual, seperti yang diterapkan saat ini oleh STMIK “AMIKBANDUNG”. Teknologi QR Code merupakan teknologi yang dapat melakukan encode dan decode semua jenis data menjadi sebuah gambar berbentuk kode dan dapat dibaca dengan smartphone, hal ini sangat cocok digunakan sebagai validasi data, yang biasanya digunakan untuk metode pembayaran digital saat ini. Dengan kelebihannya tersebut teknologi QR Code dapat diimplementasikan juga sebagai media pendukung dalam kelancaran proses presensi perkuliahan, Hal inilah yang menarik Penulis untuk melakukan penelitian mengenai perancangan presensi perkuliahan dengan menggunakan teknologi QR Code, dengan teknologi QR Code ini setiap mahasiswa diharapkan tidak perlu lagi untuk menandatangani form absen karena data presensinya akan teridentifikasi secara otomatis melalui smartphone yang dapat melakukan scan QR Code dan tersimpan didalam database sistem.
COMPETENCIAS BLANDAS: CAPITAL HUMANO COMPETENTE
Authors: Almengor Seyna
Published: August 2023

En este ensayo se pretende mostrar cómo las competencias blandas son importantes de cara a las nuevas perspectivas del mercado de trabajo que trae la globalización, teniendo presente dos de ellas: la comunicación asertiva y el trabajo en equipo. En el área de los recursos humanos, han sido consideradas como una excelente herramienta para alcanzar los objetivos de la organización y se pueden estudiar en el plano general bajo tres perspectivas: las que se adquieren con el pasar de los años, las que se pueden obtener con el transcurso de la vida, y las que se pueden potenciar a través de las capacitaciones específicas. Mientras unas se van fortaleciendo y desarrollando más que otras, en el plano laboral se requiere diferenciarlas para fomentar aquellas que conducen a un mejor clima laboral y aumentan la productividad.
Interventions for Work/Employment Participation for Autistic Adults (2013–2020)
Authors: Jirikowic Tracy , Ideishi Roger , Bendixen Roxanna , Pfeiffer Beth , Smythe Robert , Benevides Teal
Published: August 2023

Systematic Review Briefs provide a summary of the findings from systematic reviews developed in conjunction with the American Occupational Therapy Association’s Evidence-Based Practice Program. Each Systematic Review Brief summarizes the evidence on a theme related to a systematic review topic. This Systematic Review Brief presents findings on work/employment interventions and participation outcomes for autistic1 adults.
PERAN SENI KLASIK DALAM KEBUDAYAAN ISLAM
Authors: Abdullah Dindin Sofyan , Al Ayyubi Ibnu Imam , Rohmatulloh Rifqi
Published: August 2023

Islam is closely related to the aesthetics of classical art, this is enlivened by elements of culture that have such a large influence on various fields, including the fields of education, language, law, politics, philosophy, ethics, rhetoric, and art itself. Classical art is a manifestation of fine art made by the people according to the culture in a certain area for generations, inherent in the flesh so it is difficult to experience significant changes from time to time. The method used in this study is a descriptive qualitative research method with a literature study approach that refers to several research data sources and data collection techniques in the form of studies of Islamic classical art. The focus of the research that will be raised is the role of classical art in Islamic culture. The data collection technique used in this study was the library research method, namely library research and the data analysis technique used in this study was a descriptive method. Based on the research conducted, it can be concluded that classical art is inherent in Islamic religious culture, where there are ritual ceremonies that are thick with the Islamic religion, both in primitive and classical styles.
PERAN WALI SONGO DALAM MENYEBARKAN AGAMA ISLAM DI INDONESIA
Authors: Purhasanah Siti , Rohmatulloh Rifqi , Al Ayyubi Ibnu Imam
Published: August 2023

The spread of Islam to the archipelago started with merchants who wanted to trade in the archipelago. In pre-Wali Songo, precisely in the 12-13th century, the system of spreading Islam was by the da'wah method, with various multi-beliefs and cultures in society, so that the significance of belief in Islam amid society was marked by the emergence of new kingdoms, namely Islamic kingdoms with strength and followers with large numbers, then non-Islamic kingdoms at that time decreased in strength due to the proportion that became a minority. The method used in this study is a descriptive qualitative research method with a literature study approach that refers to several research data sources and data collection techniques in the form of wali songo studies. The focus of the research that will be raised is the role of the Wali Songo in spreading Islam in Indonesia. The data collection technique used in this study was the library research method, namely library research and the data analysis technique used in this study was a descriptive method. In spreading the teachings of Islam, Wali Songo has several strategies that can be accepted by the community by infiltrating local wisdom in Indonesia.
Nature-inspired Metaheuristics for finding Optimal Designs for the Continuation-Ratio Models
Authors: Qiu Jiaheng , Wong Weng Kee
Published: August 2023

The continuation-ratio (CR) model is frequently used in dose response studies to model a three-category outcome as the dose levels vary. Design issues for a CR model defined on an unrestricted dose interval have been discussed for estimating model parameters or a selected function of the model parameters. This paper uses metaheuristics to address design issues for a CR model defined on any compact dose interval when there are one or more objectives in the study and some are more important than others. Specifically, we use an exemplary nature-inspired metaheuristic algorithm called particle swarm optimization (PSO) to find locally optimal designs for estimating a few interesting functions of the model parameters, such as the most effective dose ($MED$), the maximum tolerated dose ($MTD$) and for estimating all parameters in a CR model. We demonstrate that PSO can efficiently find locally multiple-objective optimal designs for a CR model on various dose intervals and a small simulation study shows it tends to outperform the popular deterministic cocktail algorithm (CA) and another competitive metaheuristic algorithm called differential evolutionary (DE). We also discuss hybrid algorithms and their flexible applications to design early Phase 2 trials or tackle biomedical problems, such as different strategies for handling the recent pandemic.
Modeling Convective Heat Transfer of Air in a Data Center Using OpenFOAM
Authors: Barestrand Henrik , Ljung Anna-Lena , Summers Jon , Lundström Staffan
Published: August 2023

Achieving energy and cooling efficiency in data center convective air flow and heat transfer can be a challenging task. Among different numerical methods to work with such issues is the Finite Volume Method in Computational Fluid Dynamics. This work evaluates the performance of two such solvers provided by OpenFOAM® in solving this type of convective heat-transfer problem, namely BuoyantBoussinesqPimpleFOAM and BuoyantPimpleFOAM. This is done for two different flow configurations of significantly different Richardson number. To sufficiently resolve the flow, grid sizing effects are elucidated by way of the kernel density estimate. It determines the volume distribution of the temperature in the data center configuration. For the k-epsilon turbulence model used here, it was found that the compressible solver performs faster and requires less grid resolution for both flow configurations. This is attributed to the nature of the boundary conditions which are set such that the mass flow conservation per server rack and cooling unit is achieved. Transient solutions are found to provide better iterative convergence for cases that involves buoyancy, compressibility and flow separation. This is, in comparison to steady-state solutions where artificial numerical pressure drop is found, to depend on the momentum relaxation factors for the convective case with a higher Richardson number.
Medidas de prevenção de infecção de corrente sanguínea associada ao cateter central: validação de instrumento
Authors: Cruz Taísa Pereira da , Meschial William Campo , Nespollo Alice Milani , Cabral Danielle Bezerra , Silva Olvani Martins da
Published: August 2023

Objetivo: construir e validar um instrumento sobre conhecimento e adesão às medidas de prevenção de infecção primária da corrente sanguínea associada ao cateter venoso central. Método: estudo metodológico, de construção e validação de instrumento, analisado por sete especialistas selecionados segundo os critérios de Fehring. O instrumento foi avaliado em relação à objetividade, clareza e relevância do conteúdo. O consenso foi obtido pelo Índice de Validade de Conteúdo com valor igual ou superior a 0,78. Resultados: O instrumento elaborado apresentava, inicialmente, 23 questões e, após duas rodadas de avaliação, 22 permaneceram, 11 questões sobre conhecimento e 11 sobre adesão, resultando em um Índice de Validade de Conteúdo Global de 0,92. Conclusão: a utilização do instrumento, que apresenta evidência de validade de conteúdo altamente satisfatória, pode auxiliar a obtenção de um diagnóstico das equipes sobre conhecimento e adesão às medidas preventivas, direcionamento às ações gerenciais, assistenciais e de educação permanente.
THE ROLE OF BLOCKCHAIN TO SOLVE PROBLEMS OF DIGITAL RIGHT MANAGEMENT (DRM)
Authors: Ahmad Jehan Afwazi , Dirgahayu Teduh
Published: August 2023

In recent years, internet user was grown significantly. Even though many problems arise due to internet abuse. The sectors affected by the internet is digital assets or digital right. Various ways are done to solve the violation. One of that ways is to develop digital protection or Digital Right Management (DRM). However, the DRM technology has several disadvantages such as there is no way to track the leak and prove a copyright violation, the user is unable to authenticate the content since the content source is unknown, there is no user restriction to download the content, the system isn’t provided the feature to alienate ore transfer ownership the content to other, and the system using centralize model that requires many issues, especially trust issue. Fortunately, the blockchain is a decentralized, secure, reliable, immutable, and tamper-proof paradigm. The blockchain is also built upon public key cryptography and has a smart contract that can solve or complement DRM problems. This paper discusses how the blockchain solves DRM problems. The results show that blockchain solves DRM problems. A narrative literature review was conducted with several stages, including a source search of papers, articles and news articles on digital rights management and blockchain in the last five years. The next step is to identify keywords related to the topic, to review the sources, and to compile the paper.
IMPLEMENTATION AND ANALYSIS OF THE INTERNET OF THINGS SYSTEM FOR ELECTRICAL ENERGY MONITORING AT INSTITUT TEKNOLOGI TELKOM PURWOKERTO
Authors: I Ketut Agung Enriko , Afandi Mas Aly , Pujiharsono Herryawan , Gustiyana Fikri Nizar , Krishna Hedi , Juwono Filbert H.
Published: August 2023

Measurement of electric power usage is carried out using simple measuring instruments and the recording is still manual so that the data obtained is not real-time and accurate. This research aims to implement an electrical energy monitoring system using the Internet of Things (IoT) to obtain real-time information related to electrical energy in the education industry. This research uses an Industrial Grade Power Meter to get a more accurate measurement value. To connect the Power Meter device with the IoT system, this research uses Modbus RS485 communication and a mini PC to process data from the meter, so that the data can be sent to a server using the MQTT communication protocol, and displayed on the Dashboard. The test results of this study indicate that the monitoring system can be implemented and the system runs well with end-to-end measurement results. From the measurement results, the current value (3 phase average) has an average deviation of 0.001 Amperes, Voltage (3 phase average) has an average deviation of 0.519 V, Power factor has an average deviation of 0.012, Active power has a deviation average of 0.000 kW, reactive power with an average deviation of 0.000 kVAR, apparent power with an average deviation of 0.000 kVA and frequency with an average deviation of 0.124 Hz. Then the MQTT protocol has a quality of service with index 4 based on TIPHON standardization on delay, throughput, and packet loss parameters, and index 3 based on TIPHON standardization on jitter parameters.
SCIENTIFIC ARTICLES RECOMMENDATION SYSTEM BASED ON USER’S RELATEDNESS USING ITEM-BASED COLLABORATIVE FILTERING METHOD
Authors: Putra Utama Ferzha , Mardiansyah Triska , Faurina Ruvita , Vatresia Arie
Published: August 2023

Scientific article recommendation still remains one of the challenging issues in education, including learning process. Difficulties in finding related articles from research history and research interest have been experienced by students in collage affecting the duration of study and research time. This paper proposed a new solution by building a search engine to collect and to recommend articles related to student research topics. The system combined the web scraping method as an article data retrieval technique on google scholar and item-based collaborative filtering to recommend the article.  Parameters result produced based on items of user’s history, including item-searched, clicked, and downloaded. The system was built on a web-based scientific article recommendation system using python programming language. This system recommends articles based on the preferences of users and other users who are affiliated and who have an interest in the same item. This research showed that the validation result from the system obtained a recommendation accuracy value over 0.516801. The percentage of the RMSE error value of the recommendation system is 8.62%, or in other words that the accuracy of the recommendation system is 91.28%.
ESSENTIALS OF EDUCATIONAL STATISTICS
Authors: E Rajesh. , Ali Dr. Baig Muntajeeb , M. Dr. Naveen Kumar , Babu Dr. A. Satheesh
Published: August 2023

By Rajesh. E Dr. Baig Muntajeeb Ali Dr. Naveen Kumar M. Dr. A. Satheesh Babu
Adrenal Suppression after Prednisone Exposure in children with Steroid Sensitive Nephrotic Syndrome: Case Report
Authors: Wijayanti D. N Nani , Nugraha Putra Oki , Khusnul Faizah Ana
Published: August 2023

Adrenal suppression is a condition that refers to the deficit or inadequate cortisol production that results from exposure of the HPA axis to exogenous glucocorticoid. Corticosteroid (prednisone) is the backbone therapy for childhood nephrotic syndrome which is a sensitive steroid. According to KDIGO and IDAI, the protocol therapy for nephrotic syndrome is prednisone which given as initial and maintenance therapy. The initial therapy is by giving prednisone 60 mg/m2 for 3 – 4 weeks in divided dose or single dose followed by the alternate day 40 mg/m2 for 4 – 12 weeks. This protocol may suppress endogenous cortisol production by inhibiting the adrenal cortex. The long suppression of the hypothalamic-pituitary-adrenal (HPA) axis has significant impact on its function for several months to years. Even though a study about adrenal suppression in children with nephrotic syndrome was conducted, it was important to assess cortisol levels in children with a high dose and long term prednisone exposure based on its protocol. All studies showed a decrease in cortisol levels in the end of treatment, it lasted for years to return in normal condition. Inability to reach cortisol level in normal range may indicate adrenal suppression. This article will discuss the potential development of adrenal suppression in the patient who treated by prednisone in divided dose by monitoring cortisol level.
Microwave Irradiation Technique: A Green Chemistry Approach for Dissolution Enhancement of Ritonavir
Authors: Memon Shakeel , Bhise Kiran S
Published: August 2023

This research was focused on improvement of aqueous solubility of Ritonavir (RIT), Antiretroviral (ART) drug by preparing solid dispersion (SD) through solvent methodology and microwave irradiation (MWI) technique as a green chemistry approach. In MWI different batches of SD were formulated by 32 factorial approach with time of exposure (X1) and power of radiation (X2) as variable quantity and dissolution rate as response (Y1). β-CD was used as hydrophilic carriers. Drug carrier magnitude relation of 1:1 resolve by phase solubility analysis and SD were assessed for drug content, percentage dissolution rate studies, FTIR, XRD, DSC and SEM analysis. The FTIR, XRD, DSC and SEM studies exhibited no interaction between RIT and excipient. In Physical mixture (PM) it shows less intensity and disappearance of sharp peaks while in SD indicates the conversion of crystalline state of RIT to amorphous state that discovered the dissolution enhancing, so the SD prepared by MWI proved to be a promising approach to increasing the dissolving rate of BCS class II drug RIT. Hence, from the all analysis studies, it absolutely was evident that factorial batch F2 was the higher. F2 coded batch (RIT: β-CD within the magnitude relation of 1:1 with time of exposure (4 min) and power of radiation (450 Watt), shows 06 folds increase i.e. 58% compared with drug discharged inside 60 min to plane RIT and SD i.e. 9 % only and 47 % respectively.
Evaluation of Antimicrobial potential of some Novel sulphonamido-4-thiazolidinone analogues on clinical strains of bacteria and fungi
Authors: Sahu Smriti , Kumar Upadhyay Prabhat , Mishra Pradeep
Published: August 2023

Within a variety of microbes, their sensitivity towards chemotherapeutic treatments varies, that changes with time, even during therapy with a particular drug. Researchers are continuously searching novel antimicrobials which are comparatively safer than existing ones. This research aimed at evaluating the antimicrobial potential of some novel synthesized analogues containing hybrid structure of sulphonamide and thiazolidinone against the selected bacterial strains such as Bacillus subtilis, Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa and selected fungi including Penicillium chrysogenum and Aspergillus niger.. The zone of inhibition revealed that all synthesized compounds inhibited microbial growth to various extents with greater sensitivity against bacterial and fungal strains. Minimum inhibitory were also determined for novel potent compounds. Compounds exhibited higher activity against all microbial strains. Altogether, antimicrobial results showed higher activity for novel thiazolidinone compounds containing sulphonamides than both the moieties separately on individual basis. The inhibition of micro-organism can be attributed to respective heterocyclic moieties with sulphonamido group playing a crucial role against microbial strains.
Bioanalytical RP-HPLC Method for Simultaneous Quantification of Rivaroxaban and Ticagrelor in Spiked Human Plasma: Validation and Stability
Authors: Eswarudu M. Mukkanti , Rao A. Lakshmana , Vijay K.
Published: August 2023

For the effective assessment of preclinical, biopharmaceutical and clinical pharmacological investigations, selective and sensitive analytical methods for the quantitative evaluation of drugs and their metabolites (analytes) are essential. Using Rilpivirine as an internal standard (IS), a simple, fast, sensitive, precise and accurate high performance liquid chromatographic method for simultaneous determination of Rivaroxaban and Ticagrelor in human plasma was developed. The analytes were extracted using a direct protein precipitation method with acetonitrile from 500μL aliquots of human plasma. The content of the drugs was assessed using a mobile phase consisting of acetonitrile and 0.1% orthophosphoric acid buffer in a 40:60 v/v ratio and with a flow rate of 1.0ml/min, and an injection volume of 10μL. A Kromasil C18 (250×4.6mm; 5µm) analytical column was used for chromatographic separation and the effluents were monitored at 265nm using a photo diode array (PDA) detector.Rivaroxaban, Ticagrelor and Rilpivirine had retention times of 4.716min, 6.396min and 5.405 min, respectively. Rivaroxaban was shown to be linear at concentrations ranging from 0.018µg/mL - 1.80µg/mL, whereas Ticagrelor was found to be linear between 0.020µg/Ml - 2.00µg/mL. The method was validated according to US-FDA guidelines, and the findings satisfied the acceptance criteria. It was successfully used to determine Rivaroxaban and Ticagrelor in human plasma at the same time and this method is applicable for the pre-clinical and clinical estimation of drugs in biological fluids.
The effect of Varenicline on Betel nut dependence in Albino wistar rats
Authors: Gupta Vishal , L C Pallavi , Rose Thomson Serenn , O Balaji , Gangachannaiah Shivaprakash
Published: August 2023

Betel nut is one of the most common addictive substance. Not many studies have explored the potential of varenicline as cessation therapy. We studied the benefits of varenicline in reducing the reward effects in rat model. Forty male albino rats of wistar strain weighing 150-250grams were used in the present study. Rats were randomized to 5 groups of 8 rats each to: Control; Betel nut group; Varenicline at doses of 0.5, 1 and 2mg/kg along with betel nut. Conditioned Place Preference (CPP) model was used for studying the drug seeking behavior. The CPP score was compared between the groups. Results showed a significant increase in body weight of rats at the end of the study compared to baseline in betel nut and varenicline groups. Compared to betel nut group (656.25±55) there was significant decrease in CPP score in Varenicline group at 0.5mg/kg (97.5±48); 1mg/kg (18.75±20) and at dose of 2mg/kg (-60±6). The study demonstrates the benefits of varenicline in betelnut dependence. There was dose dependent decrease in betel nut seeking behavior with varenicline in rat model of drug dependence.
Role of Toll-like receptor-3 antagonist on viral load of Asthma in Swiss Albino Mice
Authors: Arora Swamita , Tagde Priti , Alam Sanjar , Akram Wasim , Gupta Sangeetha
Published: August 2023

The purpose of this work was to explain how TLR3/dsRNA complex inhibitor-calbiochem affects allergic inflammation of the airways. The identification of double-stranded RNA (dsRNA) is facilitated by the TLR3 in a significant way. Mice were subjected to Poly (I: C) as a model of asthma being sensitized and challenged with PBS and ovalbumin (OVA) chemicals. TLR3/dsRNA complex inhibitor was given to the mice. Throughout the trial, body mass scaling was used to estimate the effect of drugs in mice. Lung interstitial protein and enzyme content in airways are assessed by biochemical parameters. TLR3/dsRNA complex inhibitor drastically improved the percentage of antioxidant markers like MDA, GSH, GPx and CAT in lung tissues as well as maintained the body weight throughout the treatment period in experimental animals. It is anticipated that a new TLR3/dsRNA complex inhibitor will be used clinically since it inhibits airway inflammation without causing viral treatment resistance.
Coins of Ancient Tokharistan
Authors:   Alisher Navo'i Tashkent State University of Uzbek Language and Literature, Boboyorov G'aybulla
Published: August 2023

The tamga signs images and titles engraved on coins represent symbols of ruling dynasties and the states they had founded and were as-sociated both with the territory in which they ruled and with their origin (ethnicity). In this regard, a particular interest is the caused by Old Tur-kic tamgas and titles (“Qaghan”, “Yabghu”, “Tegin”, “Tarkhan”) available on the Pre-Islamic Turkic coins of Tokharistan region (Southern Uzbekistan – Southern Tadjikistan – Northern Afghanistan) with Sogdian scripts. On the early medieval coins of Chach related to the Western Turkic Qaghan-ate (568–740), there are four types of tamgas – a lyre-shaped one with its varieties, a tamga in the form of two crossed swords, an anchor-form tamga and the diamond-form one, and the fact comes under notice that similar tamgas were engraved on the coins of the Northern Tokharistan of the same epoch. Appearance of these tamgas and titles on the territory of Chach and Tokharistan in the Early Middle Ages is directly related to poli- tical activities of the Western Turkic Qaghanate and ethno-cultural proces- ses which were taking place in Central Asia.
Cultural Linguistics: Main Issues, Trends and Tasks
Authors:   Uzbek State  World Languаges University, Ashurova Delyaram , Galieva Margarita ,   Uzbek State  World Languаges University
Published: August 2023

Linguistics of the XXI century is intensively developing the idea that language is not only an instrument of communication but also the cultural code of a nation. It happened due to the development of a new anthropocentric paradigm, which gives the human the status of being “the measure of all things” and focuses on studying the “human factor” in the language. The emergence of the anthropocentric paradigm caused the shift in linguistic views, methods of investigations and the emergence of new interdisciplinary linguistic trends such as Sociolinguistics, Cognitive Linguistics, Cultural Linguistics (Linguoculturology), Gender Linguistics, etc., which focus on the study of relationships between language and society, language and mind, language and culture. Among these trends, one of the actively developing interdisciplinary linguistic sciences is Cultural Linguistics (Linguoculturology) aimed to investigate the correlation between language and culture, between linguistic meanings and the concepts of universal and national cultures. Currently, though Linguoculturology is a comparatively new science there distinguished within it several trends: lexicographical, phraseological, conceptological, stylistic and comparative. Each of these trends focus on the investigation of a particular aspect of Cultural Linguistics and therefore they have their own research problems and tasks. The article deals with the identification of these trends, and highlights their theoretical assumptions, evolution, main problems and achievements done within each trend.
“As much as I belong”: Space, Affect, and Identity in Isabella Hammad’s The Parisian
Authors: Pataki Éva
Published: August 2023

Atmosphere, as theorized by Gernot Böhme (1993), has both mental and physical connotations, connecting people and places in mutually constitutive and transformative relations. Investigated from the aspect of emotional geography’s concern with the spatiality of emotions (Davidson et al. 2007), the atmosphere of places and spaces may be inextricably linked to bodily experience, affect, and affective human relationships, and may play a vital part in one’s sense of belonging and self.  With a specific focus on these interconnections, my paper offers a close reading of Isabella Hammad’s debut novel, The Parisian or Al-Barisi: A Novel (2019), mapping the protagonist, Midhat Kamal’s emotional geographies through his physical journey from Nablus to Montpellier, Paris, and back, as well as his concomitant journey of the self from immigrant to flâneur, tourist to “the Parisian.” I shall argue that the protagonist’s bodily and lived experience and the atmosphere of the places/spaces he inhabits greatly determine his affective relationships, as well as his sense of home, belonging, and self, contributing to his identity (re-)construction as a transnational subject and creating the emotional geographies of his life.
New technologies and jobs in Europe
Authors: Albanesi Stefania , Dias da Silva António , Jimeno Juan F. , Lamo Ana , Wabitsch Alena
Published: August 2023

We examine the link between labour market developments and new technologies such as artificial intelligence (AI) and software in 16 European countries over the period 2011-2019. Using data for occupations at the 3-digit level in Europe, we find that on average employment shares have increased in occupations more exposed to AI. This is particularly the case for occupations with a relatively higher proportion of younger and skilled workers. This evidence is in line with the Skill-Biased Technological Change theory. While there is heterogeneity across countries, very few countries show a decline in the employment shares of occupations more exposed to AI-enabled automation. Country heterogeneity for this result appears to be linked to the pace of technology diffusion and education, but also to the level of product market regulation (competition) and employment protection laws. In contrast to the findings for employment, we find little evidence for any correlation between wages and potential exposures to new technologies.
Measuring the impact of fiscal indicators on the quality of life in the Republic of Moldova
Authors: Pârţachi Ion , Şişcan Natalia
Published: August 2023

The quality of life is one of the most important UN-recognized indicators characterizing the level of a country's development. Social policy is recognized as the most significant sphere of interests of modern society and the most important part of the activity of a modern state. Therefore, the problem arises of constructing qualitative forecasts to determine what the level and quality of life will be after the application of managerial influences. The goal of the article is to establish the relationship between economic and social factors. Knowledge of this relationship will allow to take into account the effects arising from changes in economic indicators. Of the many indicators characterizing the quality of life, we selected those that most fully represent the well-being of the population, the quality of the social sphere and education. An econometric model of the relationship between the above indicators and the main fiscal indicators was built.
Determination of academic performance by using the nonparametric method in the agricultural higher education institutions in Romania and the Republic of Moldova
Authors: Cimpoieş Dragoş , Racul Anatol , Reșitca Rodica
Published: August 2023

During the process of transition to the market economy, a series of reforms have been undertaken to improve the performance management in the agricultural sector by using the traditional methods of organizing the didactic, research and innovation process. Because the performance evaluation techniques were technically and morally outdated, the impact of the reforms did not reach the goals set. The need to evaluate the performance of the teachers in the institutions of agronomic higher education creates the necessary premises to achieve a match between the requirements imposed on the job occupied with the professional qualities and skills of the one being evaluated. At the same time it is necessary to provide a motivational system as efficient as possible to raise the individual performance level.
Historical course of accounting in the Republic of Moldova: realities and trends
Authors: Lazari Liliana , Grigoroi Lilia , Bajan Maia
Published: August 2023

In this article, it will be conducted a study on the historical course of accounting in the Republic of Moldova (after independence in 1991) with the establishment of periods of changes, periodization in terms of regulatory approach and description of the specific aspect. It is well known that accounting has been and is dependent on the economic and social development. Therefore, over time, accounting is going through a process of modernization in the Republic of Moldova, and to know the tendency of accounting evolution in the Republic of Moldova in the future, you really need to know its history so far. The research aims to identify the challenges and effects of changes in accounting. The research used scientific research methods, such as: analysis of the legal framework governing the study, synthesis of information, comparison to identify distinctive features, deduction of challenges, and impact assessment through the effects of accounting reforms.
A study on the evolution of the audit in the rm in the context of economic regulations
Authors: Şoimu Sergiu , Bădicu Galina
Published: August 2023

According to the latest ascents of international and national economic realities, the responsibility assigned to the audit activity becomes a premise for ensuring correct, objective, transparent, and especially comparable financial-accounting information, on the basis of which the best possible economic decision can be made. In this context, the general accounting and auditing framework is continuously improving the quality of its accounting information by applying accounting regulations in line with European Union Directives. Thus, the European Union seeks to align European accounting standards with International Financial Reporting Standards (IFRS) and, at the same time, use a single language in conducting business by finding a point of convergence. As a result, entities must increase their parameters of information competitiveness in relation to competitors in the domestic and international market, because information is the only inexhaustible resource and becomes a real power factor, a good that directly influences the degree of prosperity of an entity. Taking into account the frequent changes in the legislation, we considered important an analysis of the audit entities from the perspective of knowing the current situation of the audit activity in the Republic of Moldova. For this purpose, we conducted a research at the level of audit entities in the Republic of Moldova. From the methods of collecting and systematizing the information, a quantitative research method was chosen, based on a questionnaire. An online questionnaire (Google form) was developed to conduct the research. In this regard, 22 questions were asked, with several options for answers. The design of the questionnaire and the formulation of the questions aimed at observing the main objective of the paper on the evolution of the audit in order to determine the development trends of the profession and adaptability to the current context by identifying the main challenges and skills needed for auditors, the priorities of the audit entities and the advantages of the technology in carrying out the audit missions.
Critical considerations on the management of operative data on SARS-COV-2 virus infection in the republic of Moldova
Authors: Oprea Sergiu
Published: August 2023

The topicality of the scientific paper is determined by the evolution of the epidemiological situation of SARS-Cov-2 virus infection in the Republic of Moldova and the lack of medical information systems, which would ensure rapid collection, operational management and efficient analysis of primary data on infected persons, able to generate consolidated reports in institutional, territorial, time profiles.
Model of transport with restrictions on harmful emissions
Authors: Baractari Anatolie , Blanuţa Ştefan , Godonoagă Anatol
Published: August 2023

Transport systems (organizations, companies that provide services for the transport of goods from supply to consumption), as well as production, in their activity generate significant emissions of pollutants. The latter being very harmful to the environment, but also for society. The paper considers a generalization of the classical transport model in which certain restrictions on harmful emissions generated by the activity of transport systems are taken into account.
Binary relations and issues related to dialogue structuring in information systems
Authors: Пелин Николае
Published: August 2023

В работе представлены вопросы структуризации диалога в информационных системах, где оперируют информацией, представленной в виде бинарных отношений. Исследованы возможные оригинальные вопросы, которые можно адресовать системе на естественном языке с целью извлечения информации из фактов, представленных в бинарных отношениях. Выявлена модель, позволяющая получить представление о максимально возможном количестве таких вопросов, их смысловой нагрузки и, таким образом, получить представление о полном списке функций информационной системы, подлежащих разработке для получения ответов на эти вопросы.
Financing and development of the small and medium enterprise sector in the Republic of Moldova: achievements and current controversies
Authors: Cobzari Ludmila , Erhan Lica
Published: August 2023

Prezenta cercetare urmărește retrospectiv dezvoltarea sectorului întreprinderilor mici și mijlocii (IMM) din Republica Moldova, punând accent pe realizările marcate, dar și carențele rămase în dezvoltarea acestuia. În special, sunt detaliate măsurile de susținere financiară întreprinse în ultimii ani și trecute în revistă realizările obținute. Finanțarea și dezvoltarea businessului mic şi mijlociu este o parte integrată şi extrem de importantă a politicii social-economice a statului, desfăşurată cu scopul creării unor condiţii favorabile dezvoltării IMM-lor, în special în acele direcţii de activitate care generează importante beneficii social-economice. Pentru realizarea acestui suport sunt prevăzute acte legislative şi normative din domeniu, care prin prevederile sale, reglementează problemele aferente creării şi funcţionării IMM-lor şi contribuie la implementarea programelor de stat cu caracter financiar, tehnologic sau informaţional. Din punct de vedere metodologic, în acest articol sunt utilizate o serie de metode de analiză aplicate frecvent în practica naţională şi internaţională în studierea IMM-urilor pentru a putea cerceta și anticipa evoluţia acestora spre o dezvoltare echilibrată şi durabilă. Suportul informaţional al articolului a fost asigurat de datele oficiale furnizate de către Biroul Naţional de Statistică, Organizaţia pentru dezvoltarea întreprinderilor mici şi mijlocii, Rapoartele Băncii Mondiale și a Fondului Monetar Internațional. Finalitatea studiului în dinamică a sectorului IMM presupune identificarea unor propuneri concrete, menite să contribuie la dezvoltarea şi creşterea durabilă a sectorului IMM-urilor din Republica Moldova.