bluuebunny/crossref_metadata_2025 huggingface dataset:
The effect of ultraviolet on direct current potentials of the human skin
Authors: Lazarev A. O.
Published: February 2022

Aim of the study. investigation of the suntan on the level of omnipresent electrical potential of skin in frames of development of the hypothesis about the melanocyte participation in skin electrical activity formation. Material and methods. 11 men and 11 women on summer holyday took part in investigation. The relationship between the levels of skin omnipresent electrical potential and the reflection factor were investigated. The omnipresent electrical potentials were registered as the potential differences between the two areas on skin using the Orion 261S pH meter and the liquid Ag/AgCl electrodes of the same company. The reflecting factor was estimated with the help of the spectroradiometer LI-1800 (“LI-COR”) using the included intgrational sphere 1800-12 coated with barium sulfate. Hole size was 1,45 cm. The reflection factor was estimated at the wave band 375-800 nanometers with the scanning pitch 1 nm. Main results. There is a mathematical relation between the magnitudes of potential differences and the reflection factors of the areas of sunburnt skin and the areas of the skin not affected with sun at wave light 620-729 nm. The relationship could be approximated in linear equation. Spearman correlation factor between these two parameters was -0,43 (p = 0,045), between the differences in levels of skin omnipresent electrical potential and the reflection factors of the sunburnt skin was r = -0,52 (p = 0,01), between the differences of the electrical potentials of sunburnt skin and the skin not affected with sun was r = -0,28 (p = 0,2). The presented results of investigation and the data from literature allow to conclude that there is a positive correlation between the level of omnipresent electrical potential of skin and the quantity of melanosomes filled with melanin. Conclusion. It is suggested that melanocytes take part in formation of the skin electrical activity via melanosomes filled with melanin. At the same time the melanocyte contribution in skin electrical activity is not assessed.
Generalized eruptive histiocytoma: case report
Authors: Chikin V. V. , Znamenskaja L. F. , Karamova A. JE. , Smol'jannikova V. A. , Nefedova M. A.
Published: February 2022

The case of generalized eruptive histiocytoma (GEH) in woman of 49 years old is reported. GEH is a rare disease relating to non-langerhans cell histiocytoses which are based on a benign reactive proliferation of histiocytes with immunophenotype inconsistent with Langerhans cells. As a result of treatment with methotrexate and betamethasone the improvement in skin condition was achieved.
Urticaria in children: pathogenetic mechanisms and the possibilities of modern therapy
Authors: Kudryavceva A. V. , Neskorodova K. A.
Published: February 2022

The review collected the latest literature data on urticaria - one of the most frequent skin diseases in children, accompanied by the appearance of blisters. It is notorious that histamine-liberation lies in the basis of the disease pathogenesis, regardless of the cause provoking an exacerbation. Precisely this explains the unified principle of therapy for all variants of urticaria -the administration of non-sedating antihistamines in the first line. Urticaria is classified for acute and chronic based on the duration of the course (up to 6 weeks or more). Experts do not recommend that physicians carry out any special diagnostic measures in the acute form of the disease, paying the utmost attention to the administration of effective treatment. the review describes the causes of disease exacerbation, the pathogenesis and the clinic of urticaria. Attention is paid to various options for managing patients with urticaria, published in the latest expert recommendations in Europe, America and Russia.
On the 115th anniversary of the dermatovenereology department of the academician I. P. Pavlov First St. Petersburg State Medical University (part II)
Authors: Krasnoselskikh T. V. , Sokolovskiy E. V.
Published: February 2022

The article explores the history of the Department of Dermatovenereology of the First St. Petersburg State Medical University from 1956 till present time. During this period the invaluable contribution to the development of the Department was made by eminent clinicians and scientists A. N. Aravijsky and I. M. Raznatovsky. Over the past 20 years, the department has been successfully developed under the leadership of professor Evgeny Vladislavovich Sokolovskiy.
DERMATOSCOPY AS A METHOD OF EVALUATING THE EFFICIENCY OF 5% CREAM IMYKVIMOD IN PATIENTS WITH BASAL CELL CARCINOMA OF SKIN
Authors: Zhuchkov M. V. , Sonin D. B. , Tarasova M. A.  , Kosorukova S. A.
Published: February 2022

The aim. investigation of the possibilities of dermatoscopy as a method for evaluating the effectiveness of therapy with topical imiquimod in patients with superficial basal cell carcinoma (CCB). Materials and methods. the study included 24 patients with a superficial form of CCB, who for various reasons did not undergo excisional surgical intervention and who agreed to alternative drug therapy (officinal original topical imiquimod). Patients were divided into two groups, in which the efficacy of therapy was assessed either by clinical or by dermatoscopic signs. General results. the study demonstrated the importance of dermatoscopy as a method for assessing the effectiveness of therapy with topical imiquimod; Greater prognostic significance of dermatoscopy in comparison with a simple clinical examination of mass when assessing the moment of interruption of drug therapy with imiquimod.
Modern immunochromatographic methods for determination of anti-treponema pallidum antigenantibodies
Authors: Rotanov S V , Osmanova S R , Rotanov S V , Osmanova S R
Published: February 2022

The authors present a review of research publications about clinical significance of using modern
immunochromatographic methods for determination of anti-immunodominant antigen antibodies of syphilis pathogen
Treponema pallidum.
Immunochromatographic sets of chemicals proved to be convenient in use, can be used with a small amount of biological
materials, do not demand any specialized medical equipment, have high sensitivity and specificity, in particular, for
tests with blood serum or plasma samples; when whole blood samples are used, this reduces the method sensitivity.
Immunochromatographic tests are intended for prompt express examination of the population to reveal syphilis patients
under field conditions or at medical institutions consulting primary patients and not having their own clinical laboratories.
Pro-inflammatory IL-1 and TNF alpha cytokines in affected skin foci in psoriatic patients
Authors: Katunina O R , Rezaykina A V , Katunina O R , Rezaikina A V
Published: February 2022

The article presents the authors data related to an ongoing study of the expression of pro-inflammatory IL-1 and TNF alpha cytokines in affected skin foci in psoriatic patients. The authors revealed particular features related to the increased expression of IL-1 in the skin structures with absence of TNF alpha expression.
Follicular vegetative dyskeratosis complicated with a secondary infection
Authors: Martynov A A , Matushevskaya Yu I , Katunina O R , Svishchenko S I , Martynov A A , Matushevskaya Yu I , Katunina O R , Svishchenko S I
Published: February 2022

A patient with a rare form of dermatosis, follicular vegetative dyskeratosis (Darier-White disease), was under observation.
Particular features of the case under examination are described: prevalent skin eruptions with affected mucous coats of
the oral cavity; pathologic process complicated with a secondary infection. The efficacy of neotigason, a drug belonging
to the group of synthetic retinoids, was demonstrated.
Metody korrektsii narusheniy kozhnogo bar'era pri pomoshchikosmeticheskikh sredstv Emolium u beremennykh, bol'nykhatopicheskim dermatitom
Authors: Monakhov K N , Dombrovskaya D K
Published: February 2022

Results of examination of the skin barrier in 57 pregnant women with atopic dermatitis and 48 dermatologically healthy
pregnant women are presented. In the majority of patients with atopic dermatitis significant disorders of the skin barriers
have been found out both within the lesions and on clinically normal skin. More than a quarter of dermatologically healthy
pregnants demonstrated the lack of skin barriers on the dorsal surface of the hands. Use of complex emollients (gamma
«Emolium») improved characteristics of skin barrier permeability among the individuals with atopic dermatitis.
Acnecutan in the treatment of severe forms of acne
Authors: Nazhmutdinova D K , Takha T V , Shvets O I , NAZHMUTDINOVA D K , TAKHA T V , SHVETS O I
Published: February 2022

A new technology of production of oral isotretinoin, LIDOSE®, made it possible to increase its bioavailability by 20%,
preserve high efficiency of the drug while reducing the quantity of isotretinoin to be taken orally by 20%, and, therefore,
reduce both daily and course dose of the drug. The authors present the results of a study of clinical efficiency of
Acnecutan in treatment of patients suffering from medium to severe acne taking into account side effects. They also give
data on the administration of Acnecutan, which demonstrates the highest efficiency in treatment of this disease.
Mikrobnaya ekzema: novye vozmozhnostikombinirovannoy topicheskoy terapii
Authors: Bakulev A L , Kravchenya S S , Murashkin N N , Igonina I A , Epifanova A Yu , Slesarenko N A
Published: February 2022

The authors assessed clinical efficacy and safety of Supirocin-B for patients suffering from microbial eczema.
The dynamic assessment of EASI, Dermatological Index of Symptom Scale, DLQI and results of bacterioscopic
examination showed that evident positive results of the use of Supirocin-B in patients suffering from microbial eczema are
related to the strong antibacterial action of such a topical antibiotic as Mupirocin as well as high topical anti-inflammatory
action of betamethasone dipropionate.
Incidence of congenital syphilis in Russian Federation in 2002—2012
Authors: KUBANOVA A A , MELEKHINA L E , KUBANOV A A , BOGDANOVA E V
Published: February 2022

The paper presents the assessment of dynamics of congenital syphilis incidence in Russian Federation in 2002—2012, and results of the activities, aimed to decrease the incidence of congenital syphilis.
Innovations in the external therapy of acne
Authors: Tlish M M , Katkhanova O A , Kuznetsova T G , Naatyzh Zh Yu
Published: February 2022

Goal. To assess the clinical efficacy of a monotherapy with the use of products belonging to the Hyseac line for the treatment of light acne. Materials and methods. The study involved 28 patients with light acne, who were administered products belonging to the Hyseac line as a monotherapy. The dynamics of the skin processes was assessed visually (S. Liden’s acne general severity scale) and with the use of instrumental methods — sebometry (Callegari SOFT 5.5). Results. High efficacy of the administered therapy was registered in 39% of the subjects, substantial improvement was recorded in 53% of the subjects, improvement — in 8% of the subjects while no effect was registered in 0% of the subjects. Conclusion. The drug demonstrated high clinical efficacy, good tolerance and absence of any adverse effects, which makes it possible to recommend products belonging to the Hyseac line as a monotherapy and concomitant treatment of light acne.
First experience of molecular typing and determining the antibiotic resistance of syphilis pathogen Treponema pallidum in the Russian Federation
Authors: Kubanova A A , Kubanov A A , Frigo N V , Volkov I A , Rotanov S V , Suvorova A A
Published: February 2022

The authors present the results of molecular typing and determining the antibiotic resistance of 190 T. pallidum strains sampled from primary and secondary syphilitic patients in the russian Federation in 2011—2012. molecular typing of T. pallidum strains was based on two variable gens: arp, tpr, and was supplemented with an analysis of gene tp0548 reading frame. Antibiotic resistance of syphilis strains was determined by means of sequencing the gene encoding 23S rRNA T. pallidum in such loci as A2058G and A2059G/C (resistance to macrolides), gene encoding 16S rRNA T. pallidum in locus G1058C, and determinant tetB (resistance to tetracyclines) as well as full-scale sequencing the genes encoding target proteins of β-lactams Tp47 and Tromp. As a result of molecular typing in the territory of the Russian Federation, ten subtypes of T. pallidum were revealed. Type 14 (98.4%) predominates; the share of subtype 14d/f is 91.03%; the share of subtypes 14d/Tand 14b/f, Type 14, was 2.10 and 3.16%, respectively; the share of all other subtypes (11d/f, 13d/f, 14a/a, 14a/f, 14d/g, 14d/c, 20d/f) was 0.53%. molecular markers of T. pallidum antibiotic resistance were revealed among the strains coming from the Central, Siberian and Volga federal regions of Russia: macrolides - three strains sampled in 2011; tetracyclines - two strains sampled in 2011 and one strain sampled in 2012.
Sexually transmitted infections and their impact on the reproductive health of children and teenagers
Authors: Rakhmatullina M R , Shashkova A A
Published: February 2022

The authors present the results of recent studies concerning of the epidemiology of sexually transmitted infections (STIs) in children and teenagers in the Russian Federation and abroad. The authors describe social factors contributing to the propagation of STIs among the underage. They also analyze the key directions in the prevention programs to prevent propagation of STIs among young people.
Treatment of mixed skin infections
Authors: KUZNETSOVA YU K , SIRMAIS N S
Published: February 2022

Goal. To assess the tolerance, efficacy and cosmetic acceptability of a combined topical product on the basis of a cream for the treatment of dermatoses of mixed etiology localized in skin areas with thin epidermis (intertriginous affections, face affections, cheilites). Materials and methods. This prospective, open-label, cohort study involved 40 male and female patients aged 22-58 with the diagnosed mycosis of large skin folds (n = 28), dermatoses of mixed etiology in skin areas with thin epidermis (face, ears, scrotum) (n = 12). This group comprised patients with impetigo in the beard area (n = 1), mycosis of auricle skin and postaural area (n = 2), atopic eyelid dermatitis complicated with a secondary infection (n = 4), commissural cheilitis (n = 2) and scrotum skin mycosis (n = 3).The patients received treatment on their own for 10-30 days. The treatment efficacy assessment was based on the doctor’s opinion concerning the symptom intensity and patients’ opinion with regard to their symptoms and complaints. Results. The authors revealed evident clinical efficacy and safety of the combination drug (Candiderm) for the treatment of dermatoses with secondary flora in skin folds and delicate skin areas. This study demonstrates that the Candiderm cream is a highly efficient and safe drug, which does not inhibit the adrenal cortex, well-tolerated and convenient in application.
Pityriasis rubra pilaris with the concomitant Leser — Trelat syndrome
Authors: Butareva M M , Znamenskaya L F , Bezyayeva Yu S , Kappusheva I A
Published: February 2022

The authors describe a rare case of pityriasis rubra pilaris with the concomitant Leser — Trelat syndrome. Taking into consideration contra-indications for UV therapy, Neotigason (acitretin) was prescribed in the dose of 25 mg a day. Nearly absolute regression of eruptions characteristic of pityriasis rubra pilaris and multiple seborrheic keratomas was observed.
Hyperpigmentation problem and a new method for solving it
Authors: ANDREYEVA YE V , OLISOVA O YU
Published: February 2022

Goal. To assess the efficacy and safety of Neoton serum and cream for the treatment of chloasma. Materials and methods. Ten women aged 25—60 suffering from chloasma received Neoton (Neoton cream in the morning and Neoton serum in the evening) for a month. The level of melanin in lesion foci was determined prior to and after the treatment using the Multi Skin Test Center MC 750 (Germany). Results. Prior to the treatment, the level of melanin ranged from 89 to 124 (for normal skin: from 6 to 40). The treatment with Neoton drugs resulted in a complete regression of eruptions in 30% of the women, substantial improvement in 60% of the patients and improvement in 10% of them. A reduction in the level of melanin ranging from 15 to 68 serves as an objective proof of the drug efficacy. Neither of the patients developed any adverse effects. Conclusion. Good tolerance and efficacy of Neoton serum and cream for the treatment of hyperpigmentation (chloasma) were demonstrated.
Efficacy of acne topical treatment using the isotretinoin solution
Authors: Sazykina L N , Belousova T A , Nozdrin V I
Published: February 2022

Goal. To assess the efficacy and safety of isotretinoin 0.025% in the form of a solution for external use for the treatment of patients with common acne. Materials and methods. Topical monotherapy with Retasol® (isotretinoin 0.025% solution for external application) was administered to 190 patients suffering from acne aged 12-30. Most of the patients (160 out of 190) suffered from the papulopustular acne while others suffered from the comedonal form. The solution was applied to the skin twice a day; the treatment duration was 3 months. Reduction in the amount of pimple components (comedones, papules, pustules, nodes and spots) and sebum secretion were considered as the key treatment efficacy indices. The drug safety was assessed based on subjective and objective data about any adverse events. Results. Application of the Retasol® drug produced a positive therapeutic effect in 170 patients out of 190 while complete clinical recovery was observed in 25 subjects. Application of the drug resulted in a substantial regression in all of the acne manifestations, in particular, comedones and excessive sebum secretion. Topical treatment with Retasol® did not entail any adverse events (except of the exacerbation reaction characteristic of any retinoid) or changes in blood and urine test. Conclusion. Retasol® (isotretinoin 0.025% solution for external application) is a highly efficient topical retinoid for the treatment of patients with comedonal and papulopustular acne forms and is characterized by a good safety profile.
Seborrheic scalp dermatitis: current concepts of its etiology, pathogenesis and therapy
Authors: Belousova T A , Goryachkina M V , Katranova D G
Published: February 2022

The authors provide a review of current concepts of the epidemiology, etiology, pathogenesis and treatment principles for seborrheic scalp dermatitis. They also describe the results of multiple national and foreign studies confirming high clinical efficacy of ketoconazole 2% shampoo in the therapy of seborrheic dermatitis.
Pemphigus pathogenesis: problems and prospects
Authors: MICHENKO A V , ZNAMENSKAYA L F , LVOV A N , VOLKOV I A , FRIGO N V , VOLNUKHIN V A
Published: February 2022

Provides the survey of most prospective trends of research of the pathogenesis of the true acantholytic pemphigus. Cites key results of studies of factors of genetic predisposition to the development of this bullous dermatosis. Highlights problems of studies of the role of antiself antibodies and self-antigens in pemphigus pathogenesis. Represents the apoptolyse theory, explaining mechanisms of the loss of link between keratinocytes. Discusses issues of the cellular regulation of autoimmune reactions at acantholytic pemphigus.
Acne in women with adrenic hyperandrogenism
Authors: GOLOUSENKO I Y , PERLAMUTROV Y N
Published: February 2022

Goal. Study of clinical and laboratory signs of adrenal hyperandrogenism in women with acne. Маterials and methods. 303 women with acne have been examined at the age of 20—40 years. The anamnesis has been studied and tests have been performed in order to determine the life quality as well as dermatologic and gynecologic examination with pilosis evaluation based on the Ferriman-Gallwey score , anthropometric and general clinical examination, endocrine profile studies, urine steroid profile, biochemical blood composition, as well as pelvic ultrasound and sebumetry. Results. The authors identified a group of women (n = 31) with the early onset of acne, hirsutism, android adiposity, prevalence of non-inflammatory skin eruptions, seborrhea, endocrine profile diseases according to blood test results and determination of the urine steroid profile, metabolic deviations, ineffective treatment with oral contraceptives. Conclusion. The authors revealed specific clinical and laboratory signs that can be referred to diagnostic criteria of adrenal hyperandrogenism in women with acne, which will make it possible to select the rational treatment for this category of patients in future.
Efficiency of UVA1 therapy in complex treatment of chronic dermatosis
Authors: BAKULEV A L , PLATONOVA A N , RASSKAZOV Y A , ALIPOV N V
Published: February 2022

The authors present the results of application of UVA1-therapy in complex treatment of patients with atopic dermatitis, psoriasis and scleroderma. Course of treatment has made 20 procedures of UVA1-therapy with the maximum single dose of irradiation 40 J/ш 2. The general dose of an irradiation 130—400 J/ш 2. Comparison groups received medical therapy with usage of standard doses and reception schemes, and did not differ from the basic groups on age of patients, duration and the disease form. Clinical efficiency estimated on dynamics of indexes SCORAD, PAS! and results of ultrasonic scanning of the scleroderma zones. High efficiency and safety of UVA1-therapy in complex treatment atopic dermatitis, psoriasis and scleroderma is established.
Corneal protectors in dermatology
Authors: PERLAMUTROV YU N , OLKHOVSKAYA K B
Published: February 2022

Long-term studies contributed to the formation of a separate line of dermatology - corneobiology. Studies of the composition and functions of the corneous layer defined the key directions in the therapy of dermatoses accompanied by an epidermal barrier failure. Corneal protectors formed on the basis of the dermal and membrane structure meet the key principles of corneotherapy while absence of emulsifying agents provides for the physiologic restoration of the epidermal barrier without its additional damage in the course of lipid delivery.
Efficacy of the topical therapy with Tacrolimus in case of atopic dermatitis in adults
Authors: BAKULEV A L , KRAVCHENYA S S
Published: February 2022

Objective: to assess the efficacy and safety of 0.1% Tacrolimus ointment in case of atopic dermatitis in adults during the period of exacerbation. Materials and methods. The authors conducted a study of 60 patients (37 male and 23 female patients) with atopic dermatitis aged 22—45 during the period of exacerbation. Topical therapy with Tacrolimus (0.1% ointment) was administered to 22 patients once a day for 14 days. A topical glucocorticosteroid belonging to the 3rd bioactivity class according to the European classification of topical glucocorticosteroids (Miller, Munro) (0.1% methylprednisolone aceponate ointment) was administered for the treatment of 38 patients suffering from atopic dermatitis. For the purposes of unbiased assessment of the efficacy and safety of the topical therapy with different drugs, the authors performed an ultrasonic skin examination using a digital ultrasonic high-resolution system, DUB (manufactured by TPM GmbH). Results: In the course of the therapy, the authors observed a reliable reduction in the prevalence and severity of dermatosis as well as normalization of a number of ultrasonic indices of epidermis and derma. Conclusion: The therapeutic efficacy of short-term administration of Tacrolimus is comparable by its anti-inflammatory action to such potent topical glucocorticosteroid as methylprednisolone aceponate. Unlike the topical glucocorticosteroid, administration of Tacrolimus for exacerbated atopic dermatitis does not accelerate any skin atrophy phenomena.
DINICAL AND MORPHOLOGICAL CHARACTERISTICS OF THE SKIN IN ACNE PATIENTS IN THE COURSE OF TREATMENT WITH ISOTRETINOIN IN THE FORM OF LIDOSE
Authors: SERGEYEVA I G , KRINITSYNA YU M , ONIPCHENKO V V , GVOZDAREVA M A , DYaGILEVA A A
Published: February 2022

Objective. To assess clinical and morphological changes in the skin in patients with severe to moderate acne in the course of systemic treatment with isotretinoin in the form of LlDoSE. Materials and methods. The authors conducted a study of the clinical and morphologic state of the skin in 40 patients with severe to moderate acne, who were administered the treatment with systemic retinoids. Previous external therapy was inefficient in 70% of the patients. As many as 45% of the patients developed scars as a result of the regression of acne vulgaris. To visualize the structure of the epidermis, derma and subcutaneous layer, the authors used the ultrasonic skin scanning method at the frequency of 75 M. Results. The skin scanning images obtained as a result demonstrated the possibility of visualizing inflammatory components in the derma, differences in the skin density indices in different facial zones prior to the therapy and reduction in these indices against the background of the systemic therapy with isotretinoin by the third month of the treatment.
Combined topical glucocorticosteroids in the treatment of complicated forms of atopic dermatitis
Authors: MATUSHEVSKAYA E I , SVIRSHCHEVSKAYA YE V
Published: February 2022

The authors describe mechanisms of actions of such topical drugs as Akriderm Genta and Akriderm GK in the treatment of complicated forms of atopic dermatitis.
Effect of the local corticosteroid therapy and Tacrolimus on the morphological and functional skin indices of different phototypes
Authors: SHLIVKO I L , PETROVA G A , GARANINA O YE , NEZNAKHINA M S , ELLINSKY D O , MAXIMOVA A S
Published: February 2022

Objective. To assess the effect of local corticosteroid therapy and Tacrolimus on the morphological and functional skin indices of different phototypes. Materials and methods. The authors conducted a complex assessment of the morphological and functional skin condition of different phototypes among healthy volunteers under the impact of corticosteroids and Tacrolimus. The study involved 20 healthy volunteers (10 people of the 1st and 2nd skin phototypes and 10 people of the 5th and 6th skin phototypes; 14 males and 6 females; mean age: 2з years). The morphological condition of the skin was assessed with the use of optical coherent tomography (Applied Physics Institute, Russian Academy of Sciences, Nizhny Novgorod) while the functional condition was assessed with the use of Multi Skin Test Center MC 750 (Courage+Khazaka Cologne, Germany). Results. The authors revealed that the application of local corticosteroids is accompanied with a reliable reduction in the epidermis thickness developing earlier in the subjects belonging to the 5th and 6th phototypes and, at the same time, increased transepidermal water loss and reduced corneous layer humidity. An increase in the corneous layer thickness accompanied by an increase in the humidity factor was registered in all phototypes in the areas where Tacrolimus was applied. It is possible to select the correct tactics of the anti-inflammatory therapy on the basis of monitoring the morphological and functional skin condition in the process of applying local corticosteroids: to determine the optimum duration of the corticosteroid therapy and switch to calcineurin inhibitors on a timely basis when there is a need to perform an antiinflammatory therapy to achieve the maximum efficacy with the minimum risk of complication development.
Particular features of rendering high-end medical aid in the dermatovenerology sector in 2010
Authors: MARTYNOV A A , MARJSHEVSKAYA Yll I
Published: February 2022

The authors describe particular features of rendering high-end medical aid in the dermatovenerology sector at the expense of allocations from the federal budget based on their studies of normative, legal and reporting documents related to the organization of high-end medical aid and analysis of activities of the State Research Center for Dermatology and Venereology including the results of the authors' own clinical observations.
Clinical efficacy of the microwave therapy for infectious and inflammatorydiseases of the urogenital system
Authors: Abuduev N K , Burtsev O A , Abuduyev N K , Burtsev O A
Published: February 2022

The article describes complex treatment of 56 patients suffering from with chronic prostatitis and vesiculitis with the use of microwave
irradiation (of the cm range). This complex therapy made it possible to achieve better results in the main group of patients
vs. the comparison group (71 people), who received only drug treatment. Treatment resulted in the normalization of the leukocyte
count in the prostate gland discharge and venous circulation rate in the prostatic plexus. A reduction in the diameter of the venous
lumen was observed in more cases in the group of patients undergoing a microwave therapy than in the comparison group.
Assessment of the efficacy of a new zinc pyrithione drug, Cinocap®, for treatment of patients with seborrheic dermatitis
Authors: Sheklakova M N , Sheklakova M N
Published: February 2022

The goal of this study was to assess the efficacy and safety of a zinc pyrithione drug, Cinocap® aerosol, and assess its therapeutic
equivalence to the original drug, Skin-Cap® aerosol, in patients with seborrheic dermatitis.
Study design: prospective, open-label, randomized comparative clinical study.
Patients (40) aged 18-65 were randomized into two statistically comparable groups. Patients from the first group received a monotherapy with Cinocap® aerosol for 14 days while patients from the second group were treated with Skin-Cap® aerosol.
Based on the data obtained in the course of the study, it was proved that Cinocap® is an efficient drug for treatment of seborrheic
dermatitis and is comparable to the original drug, Skin-Cap®, by its therapeutic effect and safety.
Current approach to improving balanoposthitis therapy
Authors: Perlamutrov Yu N , Chernova N I , Perlamutrov Yu N , Chernova N I
Published: February 2022

Widespread occurrence of balanoposthitis results in the need to develop highly efficient treatment methods. The activity of clinical
manifestations of the disease is directly related to the condition of local immunity and opportunistic flora as well as presence of a viral infection. Application of the Epigen Intim spray having anti-inflammatory, wound-healing, antiviral and immunomodulatory
properties for treatment of irritant balanoposthitis proved to be efficient in 90% of the study subjects. The drug therapy reduced
the duration of disease manifestations and increased the remission term. The suggested treatment method optimizes treatment
of balanoposthitis.
Immunomorphology and Morphogenesis of Affected Skin Foci at Psoriasis
Authors: KUBANOVA A A , KATUNINA O R
Published: February 2022

The article provides information about the pathogenic role of different immunocompetent cells in forming an immune inflammation in the skin of psoriasis patients, which is one of the most important factors in the development of psoriatic eruptions in case of exacerbation of the disease. The contents of CD4+ helper lymphocytes, CD8+ suppressor/cytotoxic lymphocytes, CD1a+ Langerhans cells and HLA-DR+ cells in the affected skin in psoriasis patients were analyzed. It was revealed that the development of an immune inflammation in the skin of psoriasis patients involves cells of congenital (CD1a+ Langerhans cells) and adaptive immunity (CD4+ and CD8+ Т lymphocytes), and their number grows.
New drugs for mesotherapy. Bio preparations incosmetology - evolution or revolution?
Authors: Mikhaylova N P , Mikhailova N P
Published: February 2022

The authors describe lines of drugs developed on the basis of structurally modified hyaluronic acid. They demonstrate their effect
on the synthesis of collagen fibers and state of intercellular matrix.
They also present the results of studies of efficacy of using these drugs for correction of involutional skin changes.
About linear igA/igG bullous dermatosis
Authors: SAMTSOV A V , BELOUSOVA I E
Published: February 2022

A case study of linear IgA/IgG bullous dermatosis has been described, and issues related to classification as well as clinical, histological and immunopathological signs of the disease have been discussed.
A case of late diagnostics of tertiary syphilis
Authors: MAVLYUTOVA G I , MINULLIN I K , BiLDYUK YE V , GUBAIDULLiN R M
Published: February 2022

The article describes a case of late diagnostics of tertiary syphilis affecting the musculoskeletal system in a patient who was under long-term supervision with a district general practitioner and who was diagnosed with thrombophlebitis. The diagnosis was verified only after the autotomy of the right lower leg
A case of argyria of professional origin
Authors: Kuklin I A , Kokhan M M , Bochkaryov Yu M , Yutyayeva Ye V , Volkova N V
Published: February 2022

The authors present data of an examination of a patient aged 70 suffering from a relatively rare dermatosis - argyria. The diagnosis
was confirmed by professional case history, results of the histological examination of the skin and determination of the silver
content in the biological environments and hair. The authors describe problems with diagnostics and treatment of the disease.
The influence of low and moderate doses of ultraviolet irradiation produced by the UFA-1 device possessing the wavelength of 350 to 400 nm on the parameters of skin inflammation in patients suffering atopic dermatitis
Authors: Kubanov A A , Avdienko I N
Published: February 2022

The performed investigation has shown that there is an increase of the content of CD4+ lymphocytes and an increased expression of γ-interferon in the skin of patients with atopic dermatitis comparing to healthy volunteers. Therapy with the use of UFA-1 produced more marked levels of γ-interferon positive cells in the skin (р = 0.004) in patients with clinical recovery compared to subjects with an achieved improvement, as well as a substantial reduction of the Т-helpers level within the effected skin areas (р = 0.009).
Scientific contribution of professor i.F. Zelenev to the development of dermatology and venereology in Russia (dedicated to the 150th anniversary of his birth)
Authors: Zavyalov A I , Or kin V F
Published: February 2022

The article presents data on the scientific contributions of Professor IF Zeleneva in the development of national dermatology and
venereology.
Ichthyosis hystrix: clinical signs, diagnostics, and treatment
Authors: Grebenyuk V N , Grishko T N , Basse F B , Tekucheva L V , Katunina O R
Published: February 2022

Data of the literature concerning peculiarities of the course of ichthyosis hystrix and its pathomorphological picture along the description of a clinical case of the rare form of the disease based on authors' own practice are represented.
The use of clobetasol for therapy of lichen ruber planus
Authors: Nazhmutdinova D K
Published: February 2022

Data of the literature regarding the use of clobetasol propionate for treatment of lichen ruber planus are represented. The results of authors' comparative investigations for assessment of treatment efficacy using clobetasol propionate and betamethasone valerate in patients suffering lichen ruber planus demonstrated an advantage of the use of clobetasol propionate.
Efficacy of repeated treatment courses of lactulose as a component of complex therapy in patients with psoriasis
Authors: Matusevich S L , Medvedeva I V
Published: February 2022

The results of complex investigation performed in 117 patients with progressing psoriasis are reported below. It is estimated that in case of psoriasis progression there are evidences of an excessive accumulation of low and mean molecular substances of catabolic origin in plasma and urine that accompanies to activation of the endotoxin elimination system. The intensity of endotoxicosis syndrome is interrelated with the presence of the intestinal indigestion and the severity degree of dysbiosis. An addition of lactulose (Duphalac, Solvey-Pharma) to the complex therapy of patients with psoriasis aggravation using 25 ml of the drug solution for 21 days lead to significant improvement of the endoscopic picture in the large intestine, a reduction of endogenous intoxication severity and is accompanied by marked clinical benefit.
A rare case of lamellar ichthyosis
Authors: KUKLIN I A , BOCHKARYOV YU M , KENIKSFEST YU V , ARTAMONOVA M A
Published: February 2022

The authors describe a case of a relatively rare form of dermatosis - lamellar ichthyosis being an autosomal recessive disease - in a female patient aged 22. The population frequency of lamellar ichthyosis is from 1:200 000 to 1:300 000 newborns. The authors summarized data about the clinical picture and described problems with treatment of the disease.
ULTRA PETITA DECISIONS IN THE CONTEXT OF CRIMINAL LAW ENFORCEMENT IN INDONESIA
Authors: Ramiyanto Ramiyanto
Published: February 2022

The imposition of ultra petita decisions in the practice of criminal law enforcement in Indonesia continues to be going on today. This paper tries to examine the ultra petita decisions with the provisions in the Criminal Procedure Code, and the principle of freedom and the active role of judges. In answering the problem, the writer makes use of a type of normative legal research that’s done by researching positive law. The results of the discussion display that the Criminal Procedure Code doesn’t prohibit judges from imposing ultra petita decisions. In examining criminal cases, the judge can impose decisions that are outside of the requisition or exceed the requisition of the public prosecutor. The Criminal Procedure Code only stipulates that the basis for the judge in imposing a decision is the bill of indictment. Justification for the imposition of decisions is also based on the principle of judge freedomand judges are active. Under these two principles, judges are free to impose decisions without influence from other parties and actively searching for out facts that are revealed in court for the realization of material truth as the aims of criminal procedural law. The writer's recommendations are: 1) Criminal law enforcers (judges, public prosecutors, lawyers/ defendants) need to form a common awareness that ultra petita decisions are permitted; 2) The rule by which the judge gives the ultra petita decisions needs to be made immediately, each for the short and long term.
MENAKAR PELUANG DAN TANTANGAN PENYELESAIAN SENGKETA BISNIS FINTECH SYARIAH MELALUI LAPS
Authors: Nurhayati Siti , Nurjamil  , Haris Fadhillah Muhammad
Published: February 2022

Penelitian ini dilakukan untuk menguraikan peluang dan tantangan penyelesaain sengketa bisnis fintech melalui Lembaga Alternatif Penyelesaian Sengketa (LAPS) di Indonesia. Metode penelitian yang digunakan dalam penelitian ini pendekatan legal research dan pendekatan kualitatif yaitu dengan mengkaji sumber data primer dan sekunder terkait peraturan-peraturan tentang penyelesaian sengketa bisnis di Indonesia. Hasil penelitian menunjukan fintech berperan dalam mendorong perkembangan ekonomi masyarakat khususnya sebagai alternatif pembiayaan. LAPS berperan sebagai solusi penyelesaian sengketa para pelaku bisnis di Indonesia lembaga ini dipilih karena lebih efektif dan efisien, putusan bersifat final dan binding yang bertolak belakang dengan jalur litigasi yang terkesan memakan waktu dan biaya yang mahal. Peluang LAPS sangat besar mengungat maraknya bisnis dan pembayaran berbasis digital yang masih menyisakan banyak masalah hukum sementara LAPS khsusus fintech belum tersedia dimana LAPS menyediakan layanan yang sejalan dengan bisnis digital; penyelesaiannya yang bersifat win-win solution, yang sesuai dengan karakter dunia usaha, yang wajib mengelola resiko, termasuk resiko reputasi, resiko operasional dan resiko hukum. Sedangkan tantangan yang dihadapi LAPS pada fintech antara lain : Dualisme alternatif penyelesaian sengketa fintech bisa melalui LAPS dan bisa juga melalui Badan Penyelesaian Sengketa Konsumen (BPSK); Terbatasnya infrastruktur hukum jumlah transaksi fintech yang terus meningkat sejalan dengan potensi sengketa yangakan terjadi; Ketersediaan mediator dan arbiter LAPS sektor jasa keuangan.
DEVELOPING PANORA-MED AS MEDIA FOR TEACHING DESCRIPTIVE TEXT WRITING AT SEVENTH GRADE STUDENTS
Authors: Kusuma Ronaldo Aldi , Sutapa Yuliana Yohanes Gatot , Rezeki Yanti Sri
Published: February 2022

The aim of the study was to develop a multimedia learning for the teaching and learning descriptive text writing at the seventh grade students of SMPN 1 Sepauk called Panora-Med (Panoramic Media). The method of this research was the ADDIE (analyzing, designing, developing, implementation, and evaluation) model by Branch (2009) as the procedure to develop the multimedia. However, the researcher only implemented three phases which were analyzing, designing, and developing (ADD). The multimedia functioned well and fulfilled all of the assessment criteria. Therefore, this study showed that Panora-Med learning multimedia is usable to support the teaching and learning descriptive text writing. The designed product was completed by using PowerPoint presentation. The activity in the Panora-Med learning multimedia is in the form of descriptive text writing activity which allowed the students to increase their knowledge of descriptive text writing. In conclusion, Panora-Med learning multimedia is usable to ease the teaching and learning process of descriptive text writing.
Thermal atomic layer deposition of In2O3 thin films using a homoleptic indium triazenide precursor and water
Authors: Mpofu Pamburayi , Rouf Polla , O'Brien Nathan , Forsberg Urban , Pedersen Henrik
Published: February 2022

Indium oxide (In2O3) is an important transparent conducting material widely used in optoelectronic applications. Herein, we study the deposition of In2O3 by thermal atomic layer deposition (ALD) using our recently reported indium(III) triazenide precursor and H2O. A temperature interval with self-limiting growth was found between ~270–385°C with a growth per cycle of ~1.0 Å. The deposited films were polycrystalline cubic In2O3 with In:O ratios of 1:1.20, and low levels of C and no detectable N impurities. The transmittance of the films was found to be >70% in visible light and the resistivity was found to be 0.2 mΩcm. The high growth rates, low impurities, high optical transmittance, and low resistivity of these films give promise to this process being used for ALD of In2O3 films that are good candidates for potential display and touch-screen applications.
One-Pot Synthesis of Heteroatom-Bridged Cyclic Diaryliodonium Salts
Authors: Damrath Mattis , Caspers Lucien , Duvinage Daniel , Nachtsheim Boris Johannes
Published: February 2022

Two one-pot procedures for the construction of O- and N-bridged diaryliodonium triflates are described. An effective aryne-mediated arylation of o-iodophenols and sulfonamides provides diarylether and diarylamine intermediates, which are subsequently oxidized and cyclized to the corresponding diaryliodaoxinium and iodazinium salts. Different derivatizations were applied to demonstrate their capacity as useful building blocks and gain a deeper understanding towards the general reactivity of these underdeveloped but potentially highly useful compounds.
Virtual data augmentation method for reaction prediction in small dataset scenario
Authors: Wu Xinyi , Zhang Yun , Yu Jiahui , Zhang Chengyun , Qiao Haoran , Wu Yejian , Wu Zhipeng , Wang Xinqiao , Duan Hongliang
Published: February 2022

To improve the performance of data-driven reaction prediction models, a new data augmentation method for augmenting data volumes is presented that aims to add fake data in training dataset. This method is only pay attention to small-scale reactions, and manually generates fake data which is chemical and credible molecules by replacing functional groups in reaction sites. And we call this method as virtual data augmentation. Additionally, the transformer model is introduced to explore the effectiveness of virtual data augmentation method in the task of reaction prediction based on small data sets. We apply our method to five classic coupling reactions, the results show that the overall performance of the transformer-baseline model and transformer-transfer learning model combined with virtual data augmentation method is obviously improved, compared to raw datasets. Especially for Suzuki reaction, combining transfer learning strategy and virtual data augmentation method, reaches top-1 accuracy of 97.8%. To sum up, virtual data augmentation can be used as a measure to face up the problem of insufficient data and significantly improves the performance of reaction prediction.
Operando X-ray Absorption Spectroscopy Reveals Solid Electrolyte Interphase Formation on Silicon Anodes for Li-ion Batteries
Authors: Swallow Jack , Fraser Michael , Kneusels Nis-Julian , Charlton Jodie , Sole Christopher , Phelan Conor , Bjorklund Erik , Bencok Peter , Escudero Carlos , Pérez-Dieste Virginia , Grey Clare , Nicholls Rebecca , Weatherup Robert
Published: February 2022

Solid electrolyte interphase (SEI) formation is critical to the long-term performance of Li-ion battery anodes, however probing the decomposition processes occurring at the buried electrode-electrolyte interface is a significant challenge. We demonstrate here for the first time, the use of operando soft X-ray Absorption spectroscopy in total electron yield (TEY) mode to resolve the chemical evolution of the SEI during electrochemical formation in a Li-ion cell. Interface-sensitive O, F, and Si K-edge spectra, acquired as a function of potential, reveal when key reactions occur on high capacity amorphous Si anodes cycled in conventional carbonate-based electrolytes (LP30) with and with- out fluoroethylene carbonate (FEC) as an additive. Density functional theory (DFT) calculations provide insight into the species observed and the origins of their spectral features. LiF is observed as the dominant F-containing SEI product, forming at ∼0.6 V for LP30 and at a higher potential of ∼1.0 V for LP30+FEC. The formation of organic SEI components is detected at lower potentials, with the emergence of a distinct peak related to -(C=O)O- containing species. This sequential formation of inorganic and organic components is implicated in layering of the SEI. Operando TEY-XAS offers new insights into the formation mechanisms of electrode-electrolyte interphases and their stability for a wide variety of electrode materials and electrolyte formulations.
Diversity-Oriented Synthesis of Functional Polymers with Multisubstituted Small Heterocycles by Facile Stereoselective Multicomponent Polymerizations
Authors: Wang Xinnan , Han Ting , Gong Junyi , Alam Parvej , Zhang Haoke , Lam Jacky W. Y. , Tang Ben Zhong
Published: February 2022

Multicomponent polymerization (MCP) has received world-wide attention as a powerful synthetic strategy toward various polymers with complex structures. However, few studies have been reported to fully utilize the monomer combination diversity of MCPs to facilitate the synthesis of diversified polymers with novel structures and advanced functionalities. Herein, we reported a facile multicomponent polymerization route based on the diversity-oriented synthesis. Using varying combinations of difunctionalizable alkynes, sulfonyl azides and Schiff bases, diverse functional polymers with multisubstituted small heterocycles were successfully produced. High stereoselectivity was observed on specific polymeric products. The obtained azetidine-derivative heterocycles exhibit high stability even after treatment with extra HCl and KOH for 48 h. Additionally, polymers with tetraphenylethylene moieties show strong aggregation-induced emission and can function as promising chemosensors for detecting Pd2+ and Cr2O72-. The facile MCP routes present could bring new inspiration to polymer chemistry, and the fascinating functionalities of the obtained polymers with stable four-membered heterocycles could promote further research on the design, modification, and applications of diversified functional polymer materials.