bluuebunny/crossref_metadata_2025 huggingface dataset:
Sistem Kendali Suhu Mesin Tetas Telur Ayam Buras Menggunakan Kontroler PID dengan Metode Tuning Ziegler Nichols Open Loop Step Response
Authors: Agustian Indra , Prakoso Dian S , Faurina Ruvita , Daratha Novalio
Published: September 2023

An egg incubator is a tool that helps the process of hatching eggs using an electric heater and is equipped with an egg rack that functions to evenly distribute the heat in the incubator. Good temperature control in the hatching process is something that greatly affects the hatching results. In this study, an egg incubator temperature control system was designed using the PID method with the Ziegler Nichols Open Loop Step Response tuning method. The control system is specifically for free-range chicken eggs which require a normal temperature of 37 °C-39 °C. The main control components are the microcontroller, the incandescent lamp heater, and the DHT22 temperature sensor. The open loop test shows a time delay of 20 seconds and a time constant of 385 seconds, so with the Ziegler Nichols open loop tuning method, the values of Kp = 23.1, Ki = 40, and Kd = 10. The test results show that the PID controller can control the temperature properly. In testing the hatching process within 21 days, the temperature control worked well, and the effect of changes in day and night temperature did not significantly affect the performance of the PID controller.
Implementasi Metode AHP Pada Sistem Pendukung Keputusan Wisata Taman Kota Medanw
Authors: Pebrianti Lidia , Sirait Gian Patar P. , Purba Yeremia Tiopan Pandapotan
Published: September 2023

Parks are the most alternative tourist attractions. With an open area, as well as a lot of various plants, it really supports the general public just to relax with the family. When traveling, tourists usually decide to visit interesting tourist destinations. The number of tourist destinations available, often makes tourists confused about choosing a destination according to their preferences. Therefore, this research is intended for tourists to be able to determine park tourism destinations in Medan based on several categories based on beauty, security, and facilities. One of the computational methods intended to assist in current decision making is a decision support system or Analytic Hierarchy Process (AHP). In a decision support system, any information can be processed into the best alternatives as an alternative decision result. From the results of the questionnaire analysis stage, 20 out of 31 respondents had difficulty in choosing a park tourism destination. After using the AHP method, the first place is The Le Hu Garden with a weight of 0.501, the second is followed by Taman Cadika Pramuka with a weight of 0.488, and in the last order Taman Sri Deli with a weight value of 0.473.
Pengaruh Arus Eksitasi Terhadap Pembebanan Pada Generator Sinkron Unit 7 di ULPLTA TES LEBONG PT PLN (PERSERO)
Authors: Handayani Yanolanda Suzantry , Anggita Juliana  , Irnanda Priyadi
Published: September 2023

Generator merupakan salah satu bagian dari sistem tenaga listrik yang digunakan untuk mengkonversi energi mekanik yang berasal dari putaran turbin menjadi energi listrik dengan memanfaatkan gaya gerak listrik. Eksitasi merupakan salah satu bagian yang paling krusial pada sistem Generator yang berperan untuk menghasilkan fluks yang berubah terhadap waktu, sehingga dihasilkan satu GGL induksi. Arus penguatan digunakan untuk mengatur besarnya tegangan keluaran sesuai pembebanan yang diterapkan. Adapun alat yang digunakan untuk mengatur arus eksitasi adalah Automatic Voltage Regulator (AVR). Pembebanan yang dibedakan pada pembangkit setiap waktunya berubah ubah. Oleh karenanya suatu pembangkit tenaga listrik harus mampu membangkitkan daya listrik sesuai dengan besarnya beban yang berubah-ubah tersebut. Pada pembangkitan tenaga listrik, fluktuasi pembebanan ini dapat diatasi dengan mengatur bukaan katup air dan arus eksitasi yang di-injeksikan pada rotor generator pada putaran rotor yang konstan oleh AVR sehingga dihasilkan daya listrik sesuai pembebanan yang diterapkan. Tujuan penelitian ini adalah untuk menganlisa pengaruh beban terhadap arus eksitasi. Adapun hasil yang didapatkan adalah beban berpengaruh ter-hadap arus eksistasi.
Pandemi Covid-19 Mengungkapkan Peran Non-Manusia Dalam Tradisi Silaturahmi
Authors: Tihurua Ode Zulkarnain Sahji
Published: September 2023

Pandemic covid-19 telah mengungkapkan pentingnya peran non-manusia dalam kehidupan kita (baca: manusia), termasuk dalam menciptakan atau merubah tradisi yang kita pegang sejak lama. Artikel ini mengkaji tradisi “Jalan Awat” yang dilakukan masyarakat Geser pada tanggal 2 dan tanggal 3 setiap bulan Syawal (hari kedua dan ketiga hari raya Idul Fitri) di Era Pandemi Covid-19. Tradisi jalan awat merupakan tradisi silaturahmi yang banyak dipraktekan oleh berbagai kebudayaan di Indonesia. Temuan penelitian ini mengungkapkan bagaimana satu entitas non-manusia (baca: covid-19) yang ukurannya sangat mikro mampu merubah tradisi silaturahmi suatu masyarakat yang sudah dilaksanakan secara turun-temurun. Tulisan ini menggunakan konsep “entanglements” dari Anna L. Tsing dan konsep “konstruksi budaya lingkungan” dari Roy Ellen untuk menjelaskan bagaimana keterlibatan non-manusia dalam kehidupan bersama dengan manusia dalam pembentukan dan perubahan tradisi silaturahmi. Artikel ini juga menemukan model silaturahmi yang khas pada tradisi jalan awat yang disebut sebagai “silaturahmi kolektif”. Artikel ini merupakan hasil penelitian lapangan yang dilakukan oleh penulis di desa Geser pada idul fitri tahun 2020 dan tahun 2021.
Clinical Epidemiological Studies for Improving Patient Care in Juvenile Idiopathic Arthritis
Authors:   , van Straalen Joeri William
Published: September 2023

Similar to adults, children can also develop arthritis. The most common type of chronic arthritis in children is called juvenile idiopathic arthritis (JIA) and affects roughly 1 in every 1,000 children in the Netherlands. Since the introduction of biological DMARD therapies, reaching inactive disease has become a realistic target for most JIA patients. Still, there is much room for improvement in patient care for JIA.
In this thesis, we applied traditional and advanced epidemiological research methods to patient data from the Wilhelmina Children’s Hospital, the global Pharmachild registry and collaborating registries, in order to answer clinically relevant questions for improving patient care in JIA. We described the occurrence and predicting factors of comorbidities, which are common and complicate the approach to treating JIA. We developed and validated for the first time a model for predicting uveitis, that can assist clinicians in determining screening frequencies and drug therapy. We furthermore reported a protective effect of methotrexate therapy on developing JIA-associated uveitis, identified factors that can be used to distinguish JIA from non-inflammatory chronic pain syndrome at the early diagnosis stage, and compared the effects of two common biological drug therapies on patient-reported well-being. In addition, we enrolled patients in two prospective studies, and concluded that home-monitoring using web-based questionnaires is a feasible and much appreciated method of remotely tracking disease activity, and that vaccination against meningococcal disease is safe but elicits a weaker immune response in patients using biological therapy.
Burden of infectious diseases in Europe: methodological challenges and opportunities for
public health policy
Authors:   , Cassini Alessandro
Published: September 2023

Brief summaries in English, Dutch, Italian and French
In this thesis we describe tools, resources and methodological options for estimating the
burden of infectious diseases (IDs) in the European Union (EU)/European Economic Area
(EEA) expressed in disability-adjusted life years (DALYs). The objectives were to promote
evidence-based methods in epidemiology, facilitate planning and prioritization of public
health decision making, identify gaps in surveillance data availability and quality, and provide
a comprehensive framework for communicating complex information to decision-makers.
The thesis presents the methodological challenges and solutions for calculating DALYs for
the main community-acquired infections, antimicrobial resistance (AMR), and healthcareassociated
infections (HAIs), while taking into consideration different approaches to
efficiently use data sources depending on their availability and quality. The results were put
into perspective and compared with data from other studies estimating DALYs for IDs.
Our studies found that:
• Influenza, tuberculosis and HIV/AIDS have the highest burden measured in DALYs
among the most common community-acquired infections. Vaccine-preventable
diseases have lower burden, although in countries where coverage is low the burden
can be comparable to the top three diseases.
• The burden of AMR was comparable to the cumulative burden of influenza, tuberculosis
and HIV/AIDS. It is mainly healthcare-associated (which has increased significantly in
the past decades), hence, antibiotic stewardship and enforced IPC in hospitals are the
most effective interventions.
• The burden of HAIs was twice of the other IDs under surveillance in EU/EEA countries,
making HAIs the major ID problem in the region.
• The burden of IDs varies greatly between countries and interventions to reduce the
burden need to be adapted or tailored.
The methods developed in this thesis were used to provide data to decision-makers and
promote evidence-based change. Examples included in the thesis was the shift towards
universal vaccination against tick-borne encephalitis in children in Slovenia, EU/EEA
legislation for campylobacter control in the poultry industry and the validation of strategies to combat AMR in Swiss hospitals.
Databázy v MS Access - sprievodné texty k praktickým cvičeniam
Authors: Majerník Jaroslav , Kačmariková Andrea
Published: September 2023

Vysokoškolský učebný text „Databázy v MS Access – sprievodné texty k praktickým cvičeniam“ je určený poslucháčom lekárskych fakúlt, študentom vysokých škôl netechnického zamerania i všetkým začiatočníkom v práci s databázami. Uvedie citadela do problematiky databázového spracovania údajov a vysvetlí základné princípy, ktoré je potrebné poznať pri tvorbe relačných databáz. Je preto vhodný pre tých, ktorí ešte s databázami nepracovali, prípadne začali uvažovať o tom, že svoje údaje budú spravovať pomocou svojej vlastnej databázy. Avšak, užitočné informácie tu môžu nájsť aj počítačovo „skúsenejší“ používatelia. Vysokoškolský učebný text je písaný tak, aby jeho obsah bolo možné zvládnuť so základnými znalosťami práce s počítacom a programami bežiacimi v prostredí niektorej z verzií operačného systému MS Windows URL: https://unibook.upjs.sk/
The Use of Evidence-Based Dietary Interventions for the Management of Obesity
Authors: Busetto L , Casanueva F , Ard J , Van der Schueren B , Burguera B
Published: September 2023

Obesity has become a serious public health issue worldwide, with its prevalence steadily increasing. The potential consequences of this chronic disease, including cardiovascular disease, increased morbidity, and mortality, pose a significant burden on individuals and healthcare systems. Evidence has established that lifestyle and dietary modification are central to achieving effective weight loss. One approach shown to be efficacious in achieving weight loss is the use of a very low calorie ketogenic diet (VLCKD), which includes stages of induced ketosis, followed by a reintroduction to a low calorie diet and maintenance diet. Such regimens have been shown to result in sustained weight loss and, for some people, remission of Type 2 diabetes (T2D). A similar approach, which may also be a component of the VLCKD, is the use of total or partial replacement of meals using nutritionally complete shakes, bars, or soups. These may be combined with other weight loss measures, including bariatric surgery or medications. It is important that such programmes are delivered in a structured, medically-monitored, and supportive environment, such as laid out by Obesity Canada’s ‘5As’ programme. An ‘obesity shared medical appointment’ model is a multidisciplinary approach, whereby a patient with obesity is seen by a number of healthcare specialists, depending on their comorbidities. The patient also has the opportunity to meet with obesity specialists and engage in monthly patient support groups, all of which have been shown to be successful interventions in helping patients lead a healthier lifestyle, and gain more control over their weight. The following proceedings are based on talks given by leading obesity experts, presented at the 30th European Congress on Obesity (ECO 2023), which took place in Dublin, Republic of Ireland, in May 2023.
Insights From an Expert Roundtable Discussion: Navigating Intermittent Catheterisation-Associated Complications
Authors: Moir Hannah
Published: September 2023

With a pre-specified aim of improving the standard of care of those living with intermittent catheter use, a roundtable discussion led by a panel of esteemed international experts convened in early 2023. The discussion provided valuable insights and recommendations regarding understanding the challenges associated with intermittent catheter use and catheter-associated complications (CAC).

Key issues centred on the myriad of complications associated with intermittent catheterisation (IC), including urinary tract infections (UTI), discomfort, urethral trauma, haematuria, and their impact on patient-reported outcomes. The heterogeneity of patient groups included in IC research evidence, and discrepancies in current guidelines emerged as key concerns. The panel acknowledged the lack of consensus and clarity surrounding definitions and classification of several complications related to IC and the heterogenous range of reported outcome measures, highlighting the critical need for establishing unified definitions of IC-associated complications (ICAC), and better-defined patient groups in future research, in order to avoid these issues, and produce more definitive research conclusions.

To promote clarity and consistency in terminology and clinical practice, the roundtable discussion proposed an overarching consensus definition for catheter-related complications of IC and associated endpoints, referring to these as “events that disrupt catheterisation.”

The panel also considered the potential of education and innovative catheter technology as an effective means to address these common issues. Recognising the importance of education, the experts highlighted the need for new definitions and descriptions to improve clarity and consistency in clinical practice, and more research involving the array of complications associated with intermittent catheter use. Furthermore, the discussion shed light on advancements in catheter technology, exploring the potential contributions of emerging innovations, such as next-generation catheter technology like FeelClean™ Technology (Convatec, Paddington, London, UK), in minimising complications and enhancing patient outcomes.
Investigaciones sobre la poesía del siglo de Oro (2017-2020)
Authors: Rodríguez Mansilla Fernando
Published: September 2023

Este artículo recoge las principales tendencias críticas de la investigación dedicada a la poesía del Siglo de Oro en el periodo 2017-2020. Mediante la recopilación de ediciones, monografías, volúmenes monográ/cos en revistas y libros, así como artículos, se identi/can los principales temas y perspectivas que se han generado en estos últimos años. Se comentan, igualmente, las líneas de investigación de los grupos más activos dedicados a la poesía aurisecular. Se veri/ca que esta área de estudio se encuentra en buen estado de salud, dado el volumen de producción, la innovación en los enfoques y la vitalidad de los grupos.
La escritura del remedio en el "Guzmán de Alfarache" de Mateo Alemán y en el Apócrifo de Mateo Luján de Saavedra
Authors: Le Gal-Grasset Gaëlle
Published: September 2023

Abundan en el Guzmán de Alfarache las referencias a la materia médica y, más particularmente, a los remedios. Tanto la cantidad como la especi+cidad de los empleos literales y metafóricos recalcan el profundo arraigamiento de la escritura del remedio en la autobiografía +cticia de Mateo Alemán. No obstante, y a pesar de las líneas de continuidad que existen entre la primera parte de 1599 y la segunda de 1604, cabe preguntarse qué papel desempeñó la secuela apócrifa de 1602 en la reescritura de la segunda parte auténtica alemaniana. Este artículo pretende mostrar cómo, al imitar la escritura del remedio de Mateo Alemán, Mateo Luján de Sayavedra obligó a su ilustre predecesor a rea+rmar su poética propia, diferenciándose del copiador.
El vino como remedio y la "Vinosa enfermedad". Juan de la Cueva frente a la tradición del Elogio paradójico
Authors: Molinaro Antonietta
Published: September 2023

El trabajo se propone analizar un elogio paradójico sobre el vino y su palinodia por Juan de la Cueva. Tras destacar las peculiaridades temáticas y formales del vino como objeto de alabanza, entre burla y erudición, la atención se centra en el marcado componente polémico de las dos composiciones. La resemantización por parte de Cueva del reconocido tópico burlesco de la oposición entre Baco y Febo se interpreta a la luz de la actitud con,ictiva del autor hacia los entornos académicos sevillanos y de su frustrada aspiración de reconocimiento poético en el parnaso hispalense.
Сагры в Италии: современные экономические и социальные аспекты средневековой традиции (The Sagra in Italy: Modern Economic and Social Aspects of the Medieval Tradition)
Authors: Фаис-Леутская О.
Published: September 2023

Статья посвящена такому историческому, малоизученному в научном плане, но очень популярному в Италии феномену, как сагра. Речь идет о длящихся короткое время торговых фестивалях – «потомках» древнеримских, посвященных божествам празднеств. Связанные с обрядами плодородия, в контексте христианства они превратились в парохиальные торжества в честь локального святого-покровителя, а сегодня – в действа по промоушну и продаже одного конкретного, исторически производящегося в данной местности «монопродукта» – пищевого артефакта или алиментарного сырья. В отличие от других, сугубо торговых структур (магазинов, рынков и т.д.), сагра представляет собой комплексное начинание: сохраняя традиции праздника, сопряженного с народным гуляньем, фестивальным началом и культурной программой (манифестацией локального фольклора, выступлением музыкантов и т.д.), а также масштабным застольем, она является в первую очередь полноценной коммерческой инициативой. В статье рассматриваются различные аспекты функционирования сагр: традиционные их составляющие, факторы, обусловившие жизнеспособность и ренессанс этого феномена, особенности борьбы за его «чистоту», причины популярности у населения, а также редкие и наиболее распространенные формы самих мероприятий.
This article is devoted to sagra (pl. sagre) – a historical phenomenon, poorly studied in scientific terms, but very popular in Italy. Sagre are short trade festivals – the "descendants" of the ancient Roman ones, dedicated to the deities associated with fertility rites. Christianity turned these festivals into parochial celebrations in honor of the local patron saint and today they mainly serve to promote and sell one specific, historically produced in this area "monoproduct" – raw food or cooked products. Unlike purely commercial structures like shops or markets, sagra is a complex event: while being full-fledged commercial initiative, it conserves the traditions of a holiday associated with a festival and a cultural program (manifestation of local folklore, performance of musicians, etc.) and involves a large–scale feast. The article discusses various aspects of sagre: their traditional components, the factors of their viability and rise, the struggle for its "purity", the reasons for its popularity, and unusual forms of these events.
Маскулинные образы и конструирование исландской нации в XXI веке: историографический анализ (Masculine Images and Construction of Icelandic Nation in the 21st Century: Historiographical Analysis)
Authors: Снедков Г.
Published: September 2023

Зародившись в середине XIX в., исландский национализм претерпел за полтора столетия некоторые изменения, однако доминантные маскулинные образы всегда оставались его составной частью, и в этом смысле современный этап – не исключение. Начало 2000-х гг. было отмечено резким экономическим ростом и последующей финансовой экспансией Исландии, на фоне которых особую популярность приобрели «бизнес-викинги» – банкиры и предприниматели, ответственные за этот успех. После экономического кризиса 2008–2009 гг. образ «бизнес-викинга» на какое-то время перестал быть актуальным, а распространение получили идеи об особенности исландцев, являющихся наследниками «Золотого века» (времени демократии альтинга и независимости Исландии). Эти идеи также дополнились мифом об «исключительном» антикризисном менеджменте. Тем не менее, вопреки тяжелейшей рецессии, Исландии удалось поддержать и даже укрепить свой международный престиж, основывающийся теперь на идее о том, что эта страна является «колыбелью демократии». Если раньше (2000-е) главным национальным символом был «бизнес-викинг», а Исландия воображалась страной лучших финансистов, то после кризиса стали подчеркиваться устойчивость к катаклизмам и «природные» (унаследованные от предков «Золотого века») сила и живучесть исландцев. То есть, если рассуждать в терминах Д. Пуар и К. Слутмэкерса, в дискурсе произошел переход от гетеро- к гомо-национализму.
Originating in the middle of the 19th century, Icelandic nationalism has undergone certain changes over the course of a century and a half, but dominant masculine images have always remained its integral part, and in this sense, the modern stage is no exception. Early 2000s were marked by an intense economic development and the subsequent financial expansion of Iceland, against which "business-Vikings" - bankers and entrepreneurs responsible for this success - gained particular popularity. After the economic crisis of 2008–2009 the image of a “business-Viking” lost its relevance for some time, while ideas about exclusivity of Icelanders, considered to be the heirs to the “Golden Age” of Althing democracy and independence, were spreading. These ideas were supplemented by the myth of "exceptional" anti-crisis management. Nevertheless, despite a severe recession, Iceland managed to maintain and even strengthen its international prestige, which now rests upon the idea that this country is the "cradle of democracy". If earlier (2000s) the main national symbol was the “business-Viking”, and Iceland was imagined as a country of the best financiers, then after the crisis, the emphasis moved to the resistance to cataclysms and “natural” (inherited from the ancestors of the “Golden Age”) strength and vitality of the Icelanders. Or, in terms of J.K. Puar and K. Slootmaeckers, there has been a transition from hetero- to homo-nationalism in the discourse.
Антропогенетические исследования в популяции эвенков (Anthropogenetic Studies of Evenk Populations)
Authors: Спицина Н. , Балинова Н.
Published: September 2023

В статье представлены результаты антропогенетических исследований эвенков – уникального малочисленного, в прошлом кочевого народа. Современные эвенки проживают в России, Китае и Монголии. Исследования популяционно-генетической структуры эвенков Средней Сибири проводились с 60-х годов XX века. Изучены классические биохимические маркеры генов Alb, Tf, Gc, Нр, GLO1, PGM1, EsD и АсР в популяциях коренного населения Эвенкийского автономного округа. Установлено, что население обладает нехарактерным для монголоидов сочетанием изученных генных частот. Данный среднесибирский комплекс сформировался в процессе адаптации к условиям окружающей среды. Более поздние исследования различий на уровне ДНК-маркеров ввели в научный оборот новую ценную генетическую информацию. Результаты показали, что широта расселения, обилие межэтнических контактов и территориальная удаленность популяций эвенков друг от друга привели к формированию значительных генетических различий между ними. Однако память эвенков о прародине и едином происхождении оказалась устойчивее и сильнее, чем произошедшие в поколениях генетические изменения. Социальная память народа оказалось устойчивее биологической.
The article presents the results of anthropogenetic studies of the Evenks – a unique, small ethnic group of people who were nomadic in the past. Modern Evenks live in Russia, China, and Mongolia. Population and genetic structure of the Evenks of Central Siberia have been studied since the 1960s. Our study focused on the classic biochemical markers of Alb, Tf, Gc, Нр, GLO1, PGM1, EsD and AcP genes in the populations of the indigenous peoples of the Evenk Autonomous District. It has been established that the combination of the gene frequencies in the studied population is uncharacteristic for groups of Asian ancestry. This Middle Siberian complex was shaped as a result of adaptation to environmental conditions. More recent studies of differences in the DNA markers have introduced new valuable genetic information. Their results suggest that the settlement of Evenks on vast territories, their intensive contacts with different populations, and the territorial remoteness of Evenk populations from each other led to significant genetic differences between them. However, the Evenks’ memory of their ancestral homeland and common origin proved more stable than their genetic structure. The social memory of the people turned out to be longer than biological memory.
Палеодемографическое исследование некрополя «Псебепс-3» Краснодарского края (Paleodemographic Studies of the necropolis"Psebeps-3" in Krasnodar Krai)
Authors: Боруцкая С. , Васильев С.
Published: September 2023

Проведено палеодемографическое исследование некрополя XIV – начала XV вв. на территории объекта археологического наследия «Поселение Псебепс-3» в Крымском районе Краснодарского края в 2016 г. Общее количество индивидов – 381. Группа весьма представительна, при этом кладбище формировалось немногим более века. Процентное соотношение взрослых мужчин и женщин составило 65,46% и 34,54%. Столь малое количество женщин по сравнению с мужчинами можно было бы объяснить тем, что вероятно женщины чаще умирали в детском возрасте. Средняя продолжительность жизни в группе оказалась равной 25,7 лет. Средняя продолжительность жизни взрослых женщин оказалась примерно на 5 лет меньше, чем у мужчин, что связано с высокой смертностью женщин в возрасте до 25 лет. Финальная возрастная когорта всей группы, так же, как и только женщин, не представительна. Высок процент индивидов в возрастной когорте 50+ лет у мужчин – 12,3%. Процент детской смертности – средний и составляет 31,23%. При этом почти половина детей умерли в первые пять лет жизни, а пятая часть детей умерли в возрасте до 1 года.
The “Psebeps–3” necropolis is located at the archaeological heritage site "Settlement Psebeps-3" in the Krymsky district of the Krasnodar Krai and dates back to the XIV – early XV centuries. A paleodemographic study of the necropolis was conducted in 2016. The studied sample is very representative (a total of 381 individuals), although the cemetery functioned for a short period of time – a little more than a century. The ratio of adult males and females was 65.46% and 34.54%. Such a small number of females compared to males could be explained by the frequency of early deaths among women. The average life expectancy in the group was 25.7 years. The average life expectancy of adult women was found to be about 5 years less than that of men, which is associated with a high mortality rate for women under the age of 25. The final age cohort of the whole group, as well as only women, is very small in number. The percentage of individuals in the age cohort of 50+ years among men is high – 12.3%. The child mortality in the group is average and amounts to 31.23%. Almost half of the children died in the first 5 years of life, and a fifth of the children died under the age of 1 year.
A case report on digital preoperative design, clinical application and finite element analysis for a patient with ankylosing spondylitis kyphosis
Authors: Zhu Lei , Zhang Chi , Peng Li , Cheng Zifei , Liang Xiuwen
Published: September 2023

Objective: By assessing a case of ankylosing spondylitis (AS) after thoracic lumbar protrusion deformity in a digital model and verifying its effectiveness after surgery for orthopaedic surgery process simulation, a finite element model was established for biomechanical experiments.

Method: A 56-year-old patient with AS underwent preoperative thoracic lumbar spine computed tomography. The data were reconstructed using MIMICS16.0 software and modelled to design and measure the nailing parameters. A three-dimensional model was established using ANSYS14.0 software, and the actual surgical procedure was simulated using biomechanical experiments. The model was verified by comparing the X-ray films obtained from patients during preoperative forward bending, stretching and lateral flexion, with the model further tested using the Hueter-Volkmann principle.

Result: On comparing the measurements across three different load cases (forward bending, after stretching and lateral flexion) in patients with AS after thoracic lumbar protrusion deformity and the original X-ray images, no difference was found between the model of deformation and real patient movement displacement across the vertebral body. On simulating the stress distribution, the measured T10-L4 vertebral body stress values at every point in the injured vertebrae were, on the whole, directed at both the upper and lower ends and exhibited a decreasing trend, and the stress distribution gradually decreased from the injured vertebrae (T12 and L1) to the upper and lower ends.

Conclusion: The accuracy of the research model is high, the geometric similarity is good and relevant applied anatomy can be undertaken using the model parameter measurement. This study provides a successful example of the application of digital technology in the field of spinal deformity and a novel idea for the treatment of AS-related kyphosis.
Advances of nanotechnology for intracerebral hemorrhage therapy
Authors: Wang Jiayan , Wang Tianyou , Fang Mei , Wang Zexu , Xu Wei , Teng Bang , Yuan Qijuan , Hu Xin
Published: September 2023

Intracerebral hemorrhage (ICH), the most devastating subtype of stoke, is of high mortality at 5 years and even those survivors usually would suffer permanent disabilities. Fortunately, various preclinical active drugs have been approached in ICH, meanwhile, the therapeutic effects of these pharmaceutical ingredients could be fully boosted with the assistance of nanotechnology. In this review, besides the pathology of ICH, some ICH therapeutically available active drugs and their employed nanotechnologies, material functions, and therapeutic principles were comprehensively discussed hoping to provide novel and efficient strategies for ICH therapy in the future.
Construction parameters that affect the air leaks of the envelope in dwellings in Madrid
Authors: González-Lezcano Roberto Alonso , Sanglier Contreras Gastón , Iglesias Sanz Carlos Miguel , Sancho Alambillaga Rocío , López Fernández Eduardo José
Published: September 2023

In buildings, ventilation, or rather, a lack of airtightness facilitates air leaks, from the outside to the inside and vice versa, and is not controlled. Cold air enters through the enclosure, and warm air is lost to the outdoors, due to the poor hermeticity of the facades, roofs, carpentry, ducts, etc. In order to quantify the airtightness in multi-family dwellings in Madrid, 151 blower door tests have been carried out in multi-family dwellings built in different periods whose execution has been regulated by the UNE-EN 13829 standard. Through its quantification by an n50 value, the average values of 5.8 renovations per hour have been obtained in addition to detecting the main points where air infiltration occurs. The constant improvement in the transmittance of construction elements has indicated that the entry of outside air has a progressively greater relevance to the total energy consumed by the residential sector while facilitating the uncontrolled movement of air through the building envelope. This not only implies higher energy consumption but also generates a series of problems that affect the health of the occupants, such as a lack of thermal comfort, entry of pollutants and odours, noise, inadequate operation of ventilation systems, and less protection against fire.
A graph-based explanatory model for room-based energy efficiency analysis based on BIM data
Authors: Kiavarz Hamid , Jadidi Mojgan , Esmaili Payam
Published: September 2023

Introduction: In recent years, the growing interest in building energy consumption and estimation has led to a wealth of energy data and Building Information Modelling (BIM), providing ample opportunities for data-driven algorithms to be widely applied in the building industry. However, despite promising accuracy in data-driven models for building energy estimation, they only consider building elements and their attributes independently and neglect the interconnected relationship of building elements. Also, Current data-driven models lack interpretability and are often treated as black boxes. As a result, the models cannot be fully trusted for engineering without reasoning the underlying mechanisms behind the estimation.

Method: This paper emphasizes the potential of graph-based learning algorithms, specifically GraphSAGE, in utilizing the enriched semantic, geometry, and room topology information derived from BIM data. The aim is to identify critical zones within the building based on their energy consumption characteristics. Besides that, the paper proposed a GraphSAGE explainable model by adopting the SHAP with the proposed NE-GraphSAGE prediction model to make more transparency behind the data-driven models.

Results and Discussion: Preliminary results demonstrate the potential to improve pre-construction and post-construction steps by identifying critical zones in buildings and identifying the parameters which affected the efficiency of the zones with low energy consumption.
Identification and validation of a small molecule targeting ROR1 for the treatment of triple negative breast cancer
Authors: Gupta Shradheya R. R. , Ta Tram M. , Khan Maryam , Singh Archana , Singh Indrakant K. , Peethambaran Bela
Published: September 2023

Introduction: Breast cancer is the most common cancer in women, with roughly 10–15% of new cases classified as triple-negative breast cancer (TNBC). Traditional chemotherapies are often toxic to normal cells. Therefore, it is important to discover new anticancer compounds that target TNBC while causing minimal damage to normal cells. Receptor tyrosine kinase-like Orphan Receptor 1 (ROR1) is an oncofetal protein overexpressed in numerous human malignancies, including TNBC. This study investigated potential small molecules targeting ROR1.

Methodology: Using AutoDock Vina and Glide, we screened 70,000 chemicals for our investigation. We obtained 10 representative compounds via consensus voting, deleting structural alerts, and clustering. After manual assessment, compounds 2 and 4 were chosen for MD simulation and cell viability experiment. Compound 4 showed promising results in the viability assay, which led us to move further with the apoptosis assay and immunoblotting.

Results: Compound 4 (CID1261330) had docking scores of −6.635 and −10.8. It fits into the pocket and shows interactions with GLU64, ASP174, and PHE93. Its RMSD fluctuates around 0.20 nm and forms two stable H-bonds indicating compound 4 stability. It inhibits cell proliferation in MDA-MB-231, HCC1937, and HCC1395 cell lines, with IC50 values of approximately 2 μM to 10 μM, respectively. Compound 4 did not kill non-malignant epithelial breast cells MCF-10A (IC50 > 27 μM). These results were confirmed by the significant number of apoptotic cells in MDA-MB-231 cells (47.6%) but not in MCF-10A cells (7.3%). Immunoblot analysis provided additional support in the same direction.

Discussion: These findings collectively suggest that compound 4 has the potential to effectively eliminate TNBC cells while causing minimal harm to normal breast cells. The promising outcomes of this study lay the groundwork for further testing of compound 4 in other malignancies characterized by ROR1 upregulation, serving as a proof-of-concept for its broader applicability.
Safety and efficacy of His-Purkinje system pacing in the treatment of patients with atrial fibrillation and heart failure: a systematic review and meta-analysis
Authors: Guan Lin , Wang Chuanhe , Guan Xueqing , Cheng Gong , Sun Zhijun
Published: September 2023

Aim

To evaluate the safety and efficacy of the His-Purkinje system pacing (HPCSP) in the treatment of individuals with atrial fibrillation (AF) complicated by heart failure (HF).

Methods

The PubMed, Cochrane Library, Web of Science, and Embase databases were searched through September 1, 2022. The literature was initially screened based on the inclusion and exclusion criteria. The baseline characteristics of the subjects, implantation success rate, New York Heart Association (NYHA) classification, left ventricular ejection fraction (LVEF), left ventricular end-diastolic diameter (LVEDd), QRS duration, pacing threshold, and impedance were extracted and summarized; statistical analysis was performed using RevMan 5.3 software.

Results

In all, 22 articles were included, involving 1,445 patients. Compared to biventricular pacing (BiVP), HPCSP resulted in improved cardiac function, including increased ejection fraction (MD = 5.69, 95% CI: 0.78–10.60, P = 0.02) and decreased LVEDd (MD = −3.50, 95% CI: −7.05–0.05, P = 0.05). It was also correlated with shorter QRS duration (MD = −38.30, 95% CI: −60.71–−15.88, P < 0.01) and reduced all-cause mortality and rehospitalization events (RR = 0.72, 95% CI: 0.57–0.91, P < 0.01) in patients. Left bundle branch pacing (LBBP) lowered the pacing threshold (MD = 0.47; 95% CI: 0.25–0.69; P < 0.01), and there was no statistical difference in the rate of endpoint events when comparing these two physiologic pacing modalities (RR = 1.56, 95% CI: 0.87–2.80, P = 0.14).

Conclusion

The safety and efficacy of HPCSP in patients with AF and HF were verified in this meta-analysis. HPCSP can reverse cardiac remodeling and has great clinical application value. Relatively speaking, His-bundle pacing (HBP) can maintain better ventricular electro-mechanical synchronization, and the pacing parameters of LBBP are more stable.

Systematic Review Registration

PROSPERO (CRD42022336109)
The predictive value of cardiac MRI strain parameters in hypertrophic cardiomyopathy patients with preserved left ventricular ejection fraction and a low fibrosis burden: a retrospective cohort study
Authors: Salmanipour Alireza , Ghaffari Jolfayi Amir , Sabet Khadem Nazanin , Rezaeian Nahid , Chalian Hamid , Mazloomzadeh Saeideh , Adimi Sara , Asadian Sanaz
Published: September 2023

Background

Prompt interventions prevent adverse events (AE) in hypertrophic cardiomyopathy (HCM). We evaluated the pattern and the predictive role of feature tracking (FT)-cardiac magnetic resonance (CMR) imaging parameters in an HCM population with a normal left ventricular ejection fraction (LVEF) and a low fibrosis burden.

Methods

The CMR and clinical data of 170 patients, consisting of 142 HCM (45 ± 15.7 years, 62.7% male) and 28 healthy (42.2 ± 11.26 years, 50% male) subjects, who were enrolled from 2015 to 2020, were evaluated. HCM patients had a normal LVEF with a late gadolinium enhancement (LGE) percentage below 15%. Between-group differences were described, and the potent predictors of AE were determined. A P-value below 0.05 was considered significant.

Results

LV global longitudinal, circumferential, and radial strains (GLS, GCS, and GRS, respectively) and the LV myocardial mass index (MMI) were different between the healthy and HCM cases (all Ps < 0.05). Strains were significantly impaired in the HCM patients with a normal MMI. A progressive decrease in LVGLS and a distinct fall in LVGCS were noted with a rise in MMI. AE were predicted by LVGLS, LVGCS, and the LGE percentage, and LVGCS was the single robust predictor (HR, 1.144; 95% CI, 1.080–1.212; P = 0.001). An LVGCS below 16.2% predicted AE with 77% specificity and 58% sensitivity.

Conclusions

LV strains were impaired in HCM patients with a normal EF and a low fibrosis burden, even in the presence of a normal MMI. CMR parameters, especially FT-CMR values, predicted AE in our HCM patients.
Feasibility of generating structured motivational messages for tailored physical activity coaching
Authors: Ghantasala Ramya P. , Albers Nele , Penfornis Kristell M. , van Vliet Milon H. M. , Brinkman Willem-Paul
Published: September 2023

Tailored motivational messages are helpful to motivate people in eHealth applications for increasing physical activity, but it is not sufficiently clear how such messages can be effectively generated in advance. We, therefore, put forward a theory-driven approach to generating tailored motivational messages for eHealth applications for behavior change, and we examine its feasibility by assessing how motivating the resulting messages are perceived. For this, we designed motivational messages with a specific structure that was based on an adaptation of an existing ontology for tailoring motivational messages in the context of physical activity. To obtain tailored messages, experts in health psychology and coaching successfully wrote messages with this structure for personas in scenarios that differed with regard to the persona’s mood, self-efficacy, and progress. Based on an experiment in which 60 participants each rated the perceived motivational impact of six generic and six tailored messages based on scenarios, we found credible support for our hypothesis that messages tailored to mood, self-efficacy, and progress are perceived as more motivating. A thematic analysis of people’s free-text responses about what they found motivating and demotivating about motivational messages further supports the use of tailored messages, as well as messages that are encouraging and empathetic, give feedback about people’s progress, and mention the benefits of physical activity. To aid future work on motivational messages, we make our motivational messages and corresponding scenarios publicly available.
Opportunities for digital health technology: identifying unmet needs for bipolar misdiagnosis and depression care management
Authors: Kark Sarah M. , Worthington Michelle A. , Christie Richard H. , Masino Aaron J.
Published: September 2023

Introduction

Digital health technologies (DHTs) driven by artificial intelligence applications, particularly those including predictive models derived with machine learning methods, have garnered substantial attention and financial investment in recent years. Yet, there is little evidence of widespread adoption and scant proof of gains in patient health outcomes. One factor of this paradox is the disconnect between DHT developers and digital health ecosystem stakeholders, which can result in developing technologies that are highly sophisticated but clinically irrelevant. Here, we aimed to uncover challenges faced by psychiatrists treating patients with major depressive disorder (MDD). Specifically, we focused on challenges psychiatrists raised about bipolar disorder (BD) misdiagnosis.

Methods

We conducted semi-structured interviews with 10 United States–based psychiatrists. We applied text and thematic analysis to the resulting interview transcripts.

Results

Three main themes emerged: (1) BD is often misdiagnosed, (2) information crucial to evaluating BD is often occluded from clinical observation, and (3) BD misdiagnosis has important treatment implications.

Discussion

Using upstream stakeholder engagement methods, we were able to identify a narrow, unforeseen, and clinically relevant problem. We propose an organizing framework for development of digital tools based upon clinician-identified unmet need.
Understanding the effects of COVID-19 on P-12 teachers: a review of scholarly research and media coverage
Authors: LaTronica-Herb Alexandra , Karalis Noel Tiffany
Published: September 2023

This qualitative content analysis explores the multi-dimensional challenges faced by P-12 teachers amid the seismic shifts caused by the COVID-19 pandemic. Analyzing 49 academic literature and news reports from 2020 to 2022, the study identifies personal and professional stressors experienced by teachers. Personal factors, such as diminished self-efficacy, work-life balance issues, health and safety concerns, and secondary trauma, emerged as significant stressors during the pandemic. Additionally, professional factors, including heightened workload, ambiguous responsibilities, and inadequate support, have contributed to increased burnout and contemplation of leaving the profession. Strategic interventions proposed to address these issues include enhanced administrative support, increased professional agency, stress reduction measures, promotion of work-life balance, and technical training opportunities. The study calls for renewed societal respect for the teaching profession and ongoing research into the evolving needs and challenges of educators, especially in underserved communities. The aim is to provide valuable insights and potential solutions to support teachers during and beyond the pandemic, ultimately benefiting both educators and students as they navigate the changing landscape of education.
Testosterone deficiency impairs cardiac interfibrillar mitochondrial function and myocardial contractility while inducing oxidative stress
Authors: do Val Lima Patrícia Ribeiro , Ronconi Karoline Sousa , Morra Elis Aguiar , Rodrigues Paula Lopes , Ávila Renata Andrade , Merlo Eduardo , Graceli Jones B. , Simões Maylla Ronacher , Stefanon Ivanita , Ribeiro Júnior Rogério Faustino
Published: September 2023

Introduction

Clinical studies have shown that low levels of endogenous testosterone are associated with cardiovascular diseases. Considering the intimate connection between oxidative metabolism and myocardial contractility, we determined the effects of testosterone deficiency on the two spatially distinct subpopulations of cardiac mitochondria, subsarcolemmal (SSM) and interfibrillar (IFM).

Methods

We assessed cardiac function and cardiac mitochondria structure of SSM and IFM after 12 weeks of testosterone deficiency in male Wistar rats.

Results and Discussion

Results show that low testosterone reduced myocardial contractility. Orchidectomy increased total left ventricular mitochondrial protein in the SSM, but not in IFM. The membrane potential, size and internal complexity in the IFM after orchidectomy were higher compared to the SHAM group. However, the rate of oxidative phosphorylation with all substrates in the IFM after orchidectomy was lower compared to the SHAM group. Testosterone replacement restored these changes. In the testosterone-deficient SSM group, oxidative phosphorylation was decreased with palmitoyl-L-carnitine as substrate; however, the mitochondrial calcium retention capacity in IFM was increased. There was no difference in swelling of the mitochondria in either group. These changes in IFM were followed by a reduction in phosphorylated form of AMP-activated protein kinase (p‐AMPK‐α), peroxisome proliferator‐activated receptor gamma coactivator 1‐alpha (PGC‐1α) translocation to mitochondria and decreased mitochondrial transcription factor A (TFAM). Testosterone deficiency increased NADPH oxidase (NOX), angiotensin converting enzyme (ACE) protein expression and reduced mitochondrial antioxidant proteins such as manganese superoxide dismutase (Mn-SOD) and catalase in the IFM. Treatment with apocynin (1.5 mM in drinking water) normalized myocardial contractility and interfibrillar mitochondrial function in the testosterone depleted animals. In conclusion, our findings demonstrate that testosterone deficiency leads to reduced myocardial contractility and impaired cardiac interfibrillar mitochondrial function. Our data suggest the involvement of reactive oxygen species, with a possibility of NOX as an enzymatic source.