bluuebunny/crossref_metadata_2025 huggingface dataset:
Interactive Nature of Social Media’s Comment Feature
Authors: Omoera Osakue , Guanah Jammy
Published: June 2023

Discussions through interactions between contending parties have been known to have minimised, if not completely resolved, many conflicts, and have nipped numerous others in the bud because people were able to express themselves for others to know their stands on issues. Likewise, new media technologies, ably hinged on the Internet, have further created avenues for more interactions among people in different media ecosystems. Given the variegated attributes of the Internet, most newspapers now have online versions which have provisions for readers to make comments at the end of each story or report. The comment feature of online newspapers and social media gives room for interaction among readers and users, hence, commenters are not only using it to comment on what they consume from the media, but they also use it to react and comment on the comments made by other commenters. This brings about a robust social interaction among the commenters, outside the medium that serves as the source of news or topic of discussion. In October 2020, youth in Nigeria embarked on a protest against police brutality tagged #EndSARS, SARS being the acronym for Special Anti-Robbery Squad of the Nigerian police. The youth mobilised themselves nationwide through social media and other Internet platforms to hold rallies and protests, with the major protest taking place at the Lekki Tollgate in Lagos. It is within this context that this paper looked at the social interaction that took place among commenters who commented in Sahara Reporters, Premium Times, and the online version of The Punch newspaper on the #EndSARS issue. The objectives were to find out how many comments were made in the comment sections of these selected online newspapers as they relate to their reports on #EndSARS; to ascertain how many of the comments were socially interactive, and to determine the extent the comments proffered solutions to police brutality in Nigeria. Grounded in the Social Network Theory, the study utilised content analysis and direct observation methods to gather data for evaluation while coding sheets and coding guide were used as data collection instruments. Findings revealed that commenters were engaged in interactive discussions among themselves when expressing their opinions about the #EndSARS protests. It was also discovered that some of the comments proffered solutions to the issue of police brutality, and how it can be addressed. The paper concluded that the comment feature of social media is another unique avenue for citizens to voice out their opinions, and to reach out to, and engage the “high and mighty” in the society, either within or outside government, they might not be privileged to reach through other means. Based on the findings, it was recommended, among others, that those in government, particularly in developing countries such as Nigeria should pay critical attention to the comment sections of various social media to have an idea of what the populace feel about their polices based on the report about them that citizens read in the media.
Interactivity and Ecomedia in the Digital Age
Authors: Ekpe Bassey , Wekpe Israel
Published: June 2023

Interactivity is a fundamental aspect of contemporary digital media and communication, playing a crucial role in the synergistic relationship between filmic representation and video games. This paper examines the interplay between Jeta Amata's eco-film Black November and the video game Niger Delta Commando, focusing on the narratives, themes, and imaginary worlds that define their relationship. In the context of Nigeria's Niger Delta challenges, these media forms provide alternative approaches for addressing environmental issues while maintaining relevance and competing for attention in the entertainment landscape.
Nigeria's rapidly growing video game industry holds significant potential for entertainment and economic development. This study acknowledges the integral part played by film in influencing the development of video games, as both mediums share aspects such as camera techniques, narrative structures, visual representation technologies, special effects, and thematic concerns. In this case, Niger Delta Commando allows players to determine the narrative through interactivity, offering a unique and innovative way to address the Niger Delta's environmental challenges.
Adopting a dual analytical and descriptive methodology, this paper explores the interrelatedness of the narratives linking Black November and Niger Delta Commando, reconciling leading arguments in ecomedia, and assessing the Nigerian narrative's notions of interactivity, immersion, and environment. The analysis also considers the environmental impacts of media product life cycles and addresses the differential experiences of affected populations.
The eco-film Black November is recreated in the interactive video game medium Niger Delta Commando, emphasizing the military action storyline and visual style reminiscent of the Niger Delta region's activist struggles. However, the video game primarily adopts an action-thriller plot without addressing the underlying factors contributing to violence in the region or the environmental degradation detailed in Black November.
Media products, including films and video games, have demonstrated their utility as tools for engaging with and analyzing human concerns. With video games becoming increasingly popular and accepted as an artistic medium, adaptations like Niger Delta Commando can provide more immersive representations of environmental issues. The paper proposes that future video games addressing the Niger Delta region should feature complex and nuanced intersections reflecting the region's ecological challenges, moving beyond violence and towards a more constructive engagement with the environment.
The Implementation of Canvas to Enhance English Teaching and Learning
Authors: Nguyen Thanh Nam
Published: June 2023

One Learning Management System (LMS) utilized to oversee classroom activities is Canvas. In order to provide a positive atmosphere for online teaching and learning, an LMS should be effectively administered. As a result, it is necessary for both professors and students to adapt to the selected LMS's methods. This study intends to investigate how Canvas is currently used to improve English teaching and learning procedures. The research placed greater emphasis on the opinions of the students on the teacher's usage of the Canvas application. This study used a qualitative approach. Data came through observation in the classroom, documentation, and a survey. The analysis's findings demonstrate how Canvas's capabilities, which include modules for sharing resources, discussion boards, assignments, conferencing facilities for online meetings, and deeper linkages to other platforms, have improved the teaching and learning of English. The processes of teaching and learning English have been facilitated by these often employed aspects. Even with the difficulties they faced, the students felt at ease, astonished, and interested.
PENAMBAHAN DALAM EKRANISASI NOVEL ANTARES KARYA RWEINDA KE WEB SERIES
Authors: Putri Ika Ananda , Muryati Sri , Sukarno Sukarno
Published: June 2023

This study aims to describe the form of ecranization of the additional aspects of the Antares novel to the Antares web series. This research use desciptive qualitative approach. The data in this study is the addition of plot, character, and setting in the Antares web series from the Antares novel. The data sources used are the novel Antares by Rweinda published by Loveable in 2020 and the web series Antares, produced by Manoj Punjabi and directed by Rizal Mantovani. Data collection techniques are through reading, viewing documentation, and taking notes. The data analysis technique used is comparative analysis. The results of this study obtained the form of adding plots, adding characters, and adding backgrounds which were shown through scenes in the Antares web series. There are thirty additional scenes that can be classified into thirteen scenes that show the addition of the plot (events), six scenes that show the addition of characters, and eleven scenes that show the addition of the setting. Additions are needed for the sake of a filmic angle and are still relevant to the overall content of the story.
ANALISIS NILAI MORAL DALAM NOVEL SELAMAT TINGGAL KARYA TERE LIYE
Authors: Putri Rizky Nathasya , Sumiharti Sumiharti
Published: June 2023

This research aims to describe the moral value of positive thinking aspects in the novel Selamat Tinggal by Tere Liye, aspects of helping others, aspects of true love, aspects of helping the weak selflessly, aspects of mutual respect and aspects of knowing each other in the novel. The type of research used by the author in this study is descriptive research, the problem formulated must be feasible to raise, contain scientific value, and not be too broad, qualitative research is a result of analytical procedures. Using descriptive qualitative research, the author can describe and describe the moral values in the novel Selamat Tinggal by Tere Liye. The source of research data is where the data is found, the data source of this research is sourced from a novel entitled Selamat Tinggal by Tere Liye published in 2021 in its seventh printing, totaling 360 pages. This novel has a pictorial blue cover, published by Gramedia Pustaka Utama Publisher. The author bought this novel at the Gramedia bookstore in Jambi city. Data collection techniques by reading source books related to literary theory, as well as source books related to moral values, the author looks for the novel Selamat Tinggal by Tere Liye, the author reads carefully the novel, and the author marks the findings in the form of quotes related to the moral values contained in the novel. In this study, the author can conclude that the novel Selamat Tinggal by Tere Liye consists of 32 values in which there are moral values using Wicaksono's theory.
IMPLIKATUR PADA WACANA ARGUMENTATIF DALAM SURAT PEMBACA HARIAN KOMPAS.COM EDISI AGUSTUS–SEPTEMBER 2021 (Kajian Analisis Wacana)
Authors: Amral Sainil , Tumanggor Briando
Published: June 2023

The purpose of this study is to describe the use of Implicature in Argumentative Discourse in Kompas.com Daily Reader Letter. This research is descriptive qualitative research. The primary data in this research is in the form of quotations containing implicature contained in the reader's letter of Kompas.com daily. The result of this research can be concluded that there are 88 data quotations that contain implicature. Based on the 88 quotations, there are four forms of implied declarative sentences, interrogative sentences, imperative sentences, and explicative sentences. The distribution of the data presents 18 data are declarative sentence implicatures, 15 data are interrogative sentences, 7 data are imperative sentences, and 4 data are exclamative sentences. In terms of intent, there are three implicature intentions in the form of sentences meaning appeal, sentences meaning insinuation or prohibition, and sentences meaning warning. The distribution of the data presents as many as 13 data are sentences meaning appeal, 22 data mean insinuation or prohibition, and 9 data mean warning. Based on the results of the analysis, the implicature in the form of declarative sentences is the most found, and exclamative sentences are rarely found. In terms of intent, the meaning of sarcasm or prohibition is the most common, while the meaning of warning is the least common.
ANALISIS PENANDA GRAMATIKAL DAN LEKSIKAL DALAM KUMPULAN CERPEN KOMPAS 2014
Authors: Kinanthi Syulin , Sabardila Atiqa
Published: June 2023

This article aims to: (1) analyze lexical cohesion and grammatical cohesion in the 2014 Kompas short story collection, (2) describe the meaning in the parts of lexical cohesion and grammatical cohesion. The subject of this research is the 2014 Kompas Short Story Collection with grammatical cohesion objects, namely references, substitutions; ellipsis; and conjunctions and lexical cohesion, namely repetition, synonymy, antonym, hyponymy, collocation. Data collection methods were carried out using qualitative methods using data collection techniques, namely reading and taking notes. The results of this study indicate that there are 49 grammatical cohesion data consisting of 5 data references (references), 6 data substitutions (substitutions), 5 omissions (ellipsis), and conjunctions (conjunctions) have the most data, namely 33 data. Meanwhile, lexical cohesion which consists of repetition has 5 data, 3 data synonyms, 6 data antonyms, 4 data hyponyms and 3 data collocations.Keywords: Literary Work, Cohesion, Grammatical, Lexical, Short Story
FHG Fachhochschulgesetz
Authors: Schweighofer Christian
Published: June 2023

Der aktualisierte große Kommentar zum Fachhochschul-Recht Anlässlich des 30-jährigen Gesetzesjubiläums erscheint die 2., umfassend aktualisierte Auflage des Kommentars zum Fachhochschul-Recht. Das Fachhochschulgesetz (FHG) regelt als Organisations- und Rahmengesetz das österreichische Fachhochschulwesen und überlässt den Akteurinnen und Akteuren dabei einen großen Spielraum. Das in relativer Staatsferne angesiedelte Fachhochschulwesen hat sich in seiner 30-jährigen Geschichte zum vollwertigen Teil der österreichischen Hochschullandschaft entwickelt und dabei in einer Reihe von Themenbereichen eine Vorreiterrolle für das gesamte Universitäts- und Hochschulwesen eingenommen. Im Rahmen dieses Werkes hat ein kompetentes Team alle Paragrafen zum FHG und zu bedeutsamen Nebengesetzen (HS-QSG, HSG und StudFG) auf wissenschaftlicher Basis kommentiert. Die Gesetzesgenese der aktuellen, konsolidierten Fassung des bislang achtzehn Mal novellierten FHG-Normtextes findet angemessene Berücksichtigung. Die Kommentierung zum HS-QSG, HSG und StudFG runden das Bild des soliden Werkes ab. Daneben wird aber auch die Brücke zur Praxis und täglichen Rechtsanwendung geschlagen. Der Kommentar ist ein unverzichtbares Werkzeug für alle im Hochschulbereich Tätigen und bietet zu vielen Fragestellungen sowohl ausführliche Analysen und Hintergründe als auch praxisorientierte Lösungsansätze. In diesem Umfang ist der FHG-Kommentar bislang einmalig und ein Standardwerk auf lange Zeit.
COVID – 19: A Clinical Enigma, Prevention Is the Strategy
Authors: Chowdhury Shahanara
Published: June 2023

Abstract not available

JCMCTA 2019 ; 31 (1) : 1-3
Biliary Ascariasis: Overall Perspective of Management
Authors: Hoque Md Saiful , Chowdhury Tahmina Akther , Haider Salauddin Mohammed Ali , Qurashi Sabrina Akhter , Nath Sabuj Kanti
Published: June 2023

Background: One of the common cause of admission in surgical ward with acute abdomen in Asian subcontinent is Biliary Ascariasis.The causative agent, Ascarias lumbricoides is distributed throughout the tropics & subtropics & mostly prevent is developing country due to unhygienic livelihood. This study deals with management of Biliary Ascariasis demonstrating the effectiveness of only conservative management in acute condition.

Materials and methods: This was an analytical study where 47 patients diagnosed as a case of Biliary Ascariasis were observed & managed accordingly. Complete history, diagnostic tool, complication of Ascarisis & treatment modality were analysed.

Result: Here we documented 47 patients throughout the period October-2018 to September -2019 age limit is 13 yrs to 70 yers. Out of which female patient was 78.72% where male was 21.27%. Among female patient 10.63% were pregnant at the time of presentation. 100% patient present with biliary colic, 57.44% had associated nausea & vomiting 38.99% patient present as a case of cholecystitis. Cholangitis developed was 8.5% patient, 8.5% had obstructive jaundices, 4.2% developed liver abscess, 6.38% pancreatitis, 10.63% got cholelithiasis & 8.51% develop chololadocholithiasis &/ or hepaticolithiasis. USG & CBC was advised for all patient as standard diagnostic tool. During conservative treatment endoscopy was advised to all, only 63.82% was able to do this & successful extraction of worm was possible in 26.02%.70% improved by conservative treatment & ERCP required in 10.63%.Surgery for exploring CBD was done in 1 patient (2.1%). 34.02% patient had H/O recurrent attack. 17.02% patient underwent previous endoscopic procedure & 8.51% ERCP procedure. Before discharge review USG found in 68.08% patient with evidence of clear CBD & then discharged with advice of taking Antihelmintic therapy in 2 months interval.

Conclusion: Maintenance of hygienic & regular anthelmintic therapy is all prevention of occurance & complication. only conservative management with or without minimal invasive endoscopic retrieval of worm is very much effective for improvement of symptoms.

JCMCTA 2019 ; 31 (1) : 9-12
Role of Proximal Femoral Nail Antirotation in Management of Unstable Intertrochanteric Fracture of Femur
Authors: Das Chandan Kumar , Chowdhury Md Mizanur Rahman , Matin Mohammad Qausarul , Islam Md Somirul , Uddin Md Kamal , Rahman Md Abdur
Published: June 2023

Background: The aim of this study is to evaluate the management of intertrochanteric fracture of the femur using Proximal Femoral Nail Antirotation (PFNA).

Materials and methods: Sixty patients of unstable pertrochanteric fractures were treated by closed reduction and internal fixation by proximal femoral nail antirotation from July 2015 to June 2017. Four patients were lost to follow-ups. The remaining 56 patients were followed for a mean period of 2 years. The results were evaluated by assessing the patients regarding their clinical and functional outcome at follow up as per kyle’s criteria

Results: Peroperative failure to proximal head neck blade fixation (n-1) jamming of nail (n=2) and post operative lateral migration of head neck blade (n=1) and fracture related infection (n=1) were complications observed. End results were excellent in 46.34%, good in 36.58%, fair is 14.64% and poor in 2.43%.

Conclusion: Proximal Femoral Nail Antirotation (PFNA) is the biomechanically and biologically suitable implant for the management of intertrochanteric fracture of the femur.

JCMCTA 2020 ; 31 (1) : 64-70
Neutrophil Lymphocyte Ratio as a Prognostic Factor in Acute Pancreatitis
Authors: Dey Anjan Kumer , Ahmed Farid Uddin , Paul Sujat
Published: June 2023

Background:  Different scoring systems are currently in use to stratify the severity of the acute pancreatitis to guide clinicians in triaging patients with the aim of improving outcomes. The Neutrophil-Lymphocyte Ratio (NLR) provides a rapid indication of the extent of an inflammatory process.  Its value to predict the severity of acute pancreatitis has not been well studied. The aim of this study was to investigate the prognostic value of the NLR in acute pancreatitis patients.

Materials and methods: This hospital based observational study was conducted at Medicine ward of Chittagong Medical College Hospital (CMCH) for one year period from January 2015 to December 2015. One hundred and four adult patients with a diagnosis of acute pancreatitis who fulfilled the defined inclusion and exclusion criteria were selected for the study. After obtaining informed consent clinical interviewing and physical examination were done according to predesigned case record form. Then blood was collected within one hour of admission. After getting the result, final selection were done following exclusion criteria. The patients were arranged into three groups according to NLR tertiles. Main outcome measures were intensive Care Unit (ICU)/High Dependency Unit (HDU) admission, Length of Stay (LOS) in the hospital and in-hospital mortality.   

Results: According to NLR tertiles, patients in the 3 tertile (NLR³7.6) had significantly more ICU/HDU admissions (40.6% vs. 0%), longer average LOS (7.91 vs. 4.03 days) and more death (12.5% vs. 0%) compared with those in the 1rd tertile (NLR< 3.6). The higher the NLR tertile, the Modified Early Warning Score (MEWS) also increased significantly. According to the ROC curve, NLR values were superior in predicting ICU/HDU admission and hospitalization for ³ 7 days compared to WBC and MEWS values.   

Conclusion: Elevation of the NLR during admission was significantly associated with severe acute pancreatitis and is a negative prognostic indicator in acute pancreatitis. It is superior to total WBC and modified MEWS in predicting adverse outcomes of acute pancreatitis.

JCMCTA 2020 ; 31 (1) : 90-95
Unusual Location of Intraperitoneal Fibromyoma: Rarity Does Not Rule Out the Diagnosis
Authors: Nessa Kamrun , Das Suchanda , Begum Shahana , Akhter Salma
Published: June 2023

Fibromyoma which is commonest benign tumor mostly arises from smooth muscles of uterus present in 20-25% women of reproductive age group. Round ligament Fibromyoma is rare tumor & exact incidence not known. It may mimic ovarian tumor when it was intra peritoneal and located in adnexa. Preoperative diagnosis can be made by history, clinical examination, USG, CT scan of abdomen. Surgical excision is the curative treatment. A 35 years lady para 2 presented with lump in lower abdomen gradually increasing in size for 3-4 yrs and pain for 2 months. On examination firm palpable mass of 28 weeks pregnancy size.  Her USG and CT scan detected well defined 28 cm x 22 cm X 20 cm mass in right adnexa & diagnosis given ovarian tumor. Her CA 125 level was 97unit/ml. Laparotomy finding was a big firm lobulated tumor arises from right round ligament. Tumor removed as a whole, uterus, both ovaries, and left sided fallopian tube healthy & preserved. Final histopathological diagnosis benign fibromyoma with degenerative change. So diagnosis of fibromyoma always kept in mind during the differential diagnosis of any pelvic mass.

JCMCTA 2020 ; 31 (1) : 130-133
Ectopic Cushing’s Syndrome From Prostatic Adenocarcinoma: A Rare Clinical Entity
Authors: Chowdhury Rezaul Haider , Chowdhury Sumon Rahman , Tanzil Tasnuva , Alam Md Minhazul
Published: June 2023

A 61-year-old man known to have metastatic prostate adenocarcinoma was seen at Changi General Hospital, Singapore, because of severe hypokalaemia due to ACTH dependent Cushing’s syndrome. He underwent a Dotate PET CT which showed increased DOTA-NOC-avidity in the right side of the prostate gland. Subsequent immunohistochemical staining of prostate biopsy sample documented ACTH, synaptophysin and CD 56 positivity. He was suggested medical management for prostate cancer complicated by Cushing's syndrome. Unfortunately, Cushing’s syndrome was not controlled and the patient’s clinical condition progressively worsened. Subsequently, he developed fatal sepsis due to immunocompromised state. This case report describes a case of Cushing’s syndrome due to metastatic adenocarcinoma of the prostate, a tumour with very few therapeutic options and negative prognosis.

JCMCTA 2020 ; 31 (1) : 125-129
Ihmisoikeuksien historia
Authors: Bengs Christer
Published: June 2023

Willy Strzelewics (1905-1986) oli saksalainen yhteiskuntatieteilijä ja humanisti, joka vuonna 1931 teki väitöskirjansa Max Horkheimerin (1895-1973) ohjauksessa Frankfurt am Mainissa. Pari vuotta myöhemmin hän pakeni Tsekkoslovakian ja Norjan kautta Ruotsiin. Palattuaan Saksaan vuonna 1955 hän toimi yhteiskuntatieteiden professorina. Kirja on laaja ja monipuolinen, mutta oletettavasti koottu lyhyemmistä, osin päällekkäisistä kirjoituksista. Kirjan ajankohtaisuutta korostaa sen maanpakoon liittyvä syntyhistoria. Strzelewicz osoittaa, miten aatteiden kehittelyn taustalla ovat todelliset, maailmanhistoriaan vaikuttaneet tapahtumat. Teoretisointi ankkuroituu todellisuuteen.
Penerapan Data Envelopment Analysis dalam Pengukuran Efisiensi Teknis Produktivitas Tanaman Jeruk di Kabupaten Sleman
Authors: Hardiyan  , Yunita  , Junaidi Agus , Agus Sobari Irwan
Published: June 2023

Indonesia mempunyai potensi pasar yang baik untuk komoditas jeruk, salah satunya di Sleman. Sleman merupakan kabupaten yang berada di lereng Gunung Merapi, sebagian besar tanahnya digunakan sebagai lahan pertanian. Jeruk adalah salah satu komoditas unggulan hortikultura dapat tumbuh dan berproduksi di dataran rendah sampai dataran tinggi. Di Kabupaten Sleman, untuk produksi jeruk belum dapat terpenuhi, sehingga harus mendatangkan jeruk dari wilayah lain. Oleh karenanya diperlukan pendekatan Data Envelopment Analysis  bertujuan untuk mengukur efisiensi relatif teknik produktivitas tanaman jeruk di Kabupaten Sleman. DMU didasarkan pada perbandingan data tahunan dari 2017 hingga 2021 mengacu pada data yang homogen. Pengukuran efisiensi teknis produktivitas tanaman menunjukkan tren positif kembali di tahun 2021, dimana menunjukkan pencapaian dengan tingkat efisiensi relatif mencapai 100% atau bernilai 1, sehingga dapat menjadi acuan untuk tahun-tahun berikutnya.
Efficacy of LAMP assay for Mycobacterial spp. detection to prevent treatment delays and onset of drug resistance: a systematic review and meta-analysis
Authors: Bumbrah Gurvinder Singh , Jain Sarika , Fatima Zeeshan , Hameed Saif
Published: June 2023

Background: Tuberculosis (TB) remains a deadly disease affecting one-third population globally. Long turnaround time and poor sensitivity of the conventional diagnostics are the major impediments for faster diagnosis of Mycobacterial spp to prevent drug resistance. To overcome these issues, molecular diagnostics have been developed. They offer enhanced sensitivity but require sophisticated infrastructure, skilled manpower and remain expensive.
Methods: In that context, loop-mediated isothermal amplification (LAMP) assay, recommended by the WHO in 2016 for TB diagnosis, sounds as a promising alternative that facilitates visual read outs. Therefore, the aim of the present study is to conduct a meta-analysis to assess the diagnostic efficiency of LAMP for the detection of a panel of Mycobacterium spp. following PRISMA guidelines using scientific databases. From 1600 studies reported on the diagnosis of Mycobacterium spp., a selection of 30 articles were identified as eligible to meet the criteria of LAMP based diagnosis.
Results: It was found that most of the studies were conducted in high disease burden nations such as India, Thailand, and Japan with sputum as the most common specimen to be used for LAMP assay. Furthermore, IS6110 gene and fluorescence-based detections ranked as the most used target and method respectively. The accuracy and precision rates mostly varied between 79.2% to 99.3% and 73.9% to 100%, respectively. Lastly, a quality assessment based on QUADAS-2 of bias and applicability was conducted.
Conclusion: LAMP technology could be considered as a feasible alternative to current diagnostics considering high burden for rapid testing in low resource regions.
Lesão renal aguda provocada por COVID-19: uma revisão de literatura
Authors: Aldeman Melo Nayara Sangreman , Neves Filho Carlos Alexandre Ponte , Aldeman Nayze Lucena Sangreman
Published: June 2023

Introdução: Em dezembro de 2019, uma série de casos de pneumonia foi observada em Wuhan, na China. Rapidamente, milhares de pacientes evoluíram com o mesmo quadro e, posteriormente, o agente causal foi identificado: severe acute respiratory syndrome coronavírus (SARS-CoV-2). Dentre as disfunções orgânicas relacionadas à COVID-19, a insuficiência respiratória hipoxêmica recebeu maior destaque, porém a lesão renal aguda (LRA) também tem sido muito relatada. Glomerulonefrite, rabdomiólise e drogas nefrotóxicas também estão associadas a danos renais em pacientes com COVID-19. Objetivo: A presente pesquisa tem como objetivo exemplificar e entender qual a associação da lesão renal aguda (LRA) em pacientes acometidos pela SARS-CoV-2. A LRA é tratada como um fator de gravidade afetando diretamente o quadro de saúde do paciente acometido pela infecção SARS-CoV2, em meio a uma pandemia de COVID e diante de um aumento no número de casos tornou-se necessário o estudo clínico da LRA nesses casos para assim ajudar no manejo do paciente e identificação dos fatores de risco para otimizar o diagnóstico e o tratamento, desta forma melhorando o prognóstico ao paciente. Metodologia: trata-se de uma revisão bibliográfica integrativa realizada por meio da estratégia PICO, a qual determina o conhecimento atual sobre uma temática específica. Utilizou-se das fontes de dados Pubmed, LILACS e SciELO para fazer a busca dos artigos na integra, os quais foram escolhidos mediantes critérios de inclusão e de exclusão. No final, foram encontrados 13 artigos como amostra final, para que o presente estudo fosse feito. Resultados e Discussão: A disfunção endotelial sistêmica é ocasionada pelo aumento abrupto de síntese de citocinas, em especial as IL-6, IL-2 e TNF-alfa, durante a infecção, causando uma desregulação imunológica. Esta, em especial, tem influência também sobre um estado de hipercoagulabilidade que o paciente desenvolve, a qual resulta em uma depleção do volume intravascular, que leva a uma hipotensão geradora de hipoperfusão renal. Consequentemente, a resultante é em LRA pré-renal, que tem a necrose tubular aguda (NTA) como achado histopatológico mais comum nas biópsias de rim. Conclusão: Portanto, foi observado, por meio dos estudos recentes, que há uma grande contribuição renal para o aumento da mortalidade em pacientes infectados pelos SARS-CoV-2, sendo que as complicações renais são um dos principais fatores de pior prognósticos nesses indivíduos.
Fratura coronorradicular - colagem de fragmento associado com pino de fibra de vidro: relato de caso
Authors: Souza Caian Dourado , Santos Camila Oliveira dos , Rocha Aurélio de Oliveira , Santos Valéria Pinto dos , Campos Estéfane Sobral , Oliveira Thayanne Monteiro Ramos
Published: June 2023

A reabilitação estética e funcional de dentes fraturados a nível cervical é sempre um desafio para a odontologia. Quando o fragmento permanece integro e em perfeita adaptação com o remanescente dental, a colagem do fragmento apresenta-se como uma alternativa conservadora e minimamente invasiva para recuperação de dentes fraturados. O estudo teve como objetivo relatar um caso clínico de fratura coronorradicular em incisivo central superior esquerdo, onde foi realizado cirurgia periodontal e colagem do fragmento associado com pino de fibra de vidro. Paciente do gênero masculino, 40 anos, compareceu à clínica odontológica da Universidade Tiradentes (UNIT), relatando fratura do incisivo central superior esquerdo. O exame radiográfico evidenciou uma linha de fratura obliqua, tratamento endodôntico, ausência de alteração periapical e extensa área radiopaca, sugestivo de material restaurador. O tratamento proposto foi a colagem do fragmento, sobre pino de fibra de vidro intra-radicular. Todo o procedimento foi executado sob retalho periodontal de espessura total, isolamento absoluto e finalizado com sutura colchoeiro vertical. Diante do caso clínico exposto, pode-se concluir que em virtude dos avanços da odontologia adesiva, a técnica de colagem de fragmento dental associada ao pino de fibra de vido intra-radicular proporcionam um resultado estético e funcional satisfatório para o paciente.
Avaliação de índice de resto-ingesta em uma unidade de alimentação e nutrição de um restaurante universitário
Authors: Brito Herbenny Hellen Medeiros de , Véras Ítala Viviane Ubaldo Mesquita , Souza Kátia Regina
Published: June 2023

O índice de Resto/ingesta (IR/I) é um indicador comumente utilizado nas Unidades de Alimentação e Nutrição para verificar a satisfação do consumidor com o cardápio oferecido e avaliarem o desperdício de alimentos. Com isso, o objetivo deste trabalho é avaliar o resto-ingesta em uma unidade de alimentação e nutrição de um restaurante universitário. Este estudo é do tipo observacional, quantitativo e descritivo, realizado na UAN do Restaurante Universitário da UFRN. Os dados de rejeito alimentar da clientela da unidade central foram referentes ao período de maio a julho de 2022. Os resultados demonstraram um índice de resto-ingesta médio, nos meses de maio, junho e julho de 7,03%, 7,95% e 7,11% respectivamente, que é classificado como bom. Esse resultado satisfatório pode ser associado a algumas estratégias que o local já realiza como campanhas contra o desperdício anualmente, avaliação de aceitação diária das preparações servidas e padronização da forma de preparo através do uso de fichas técnicas. Entretanto, apesar dos percentuais de índice de resto-ingesta serem considerados satisfatórios na maioria dos dias, há ainda a necessidade de medidas para melhoria já que tiveram alguns dias que estavam elevados. Isso demonstra que devem ser intensificadas as intervenções em relação ao processo produtivo dos cardápios executados no RU, sendo necessário a supervisão da execução fiel das fichas técnicas de preparo, revisão das técnicas gastronômicas e culinárias, além da conscientização entre os manipuladores assim como medidas de Educação Alimentar e Nutricional com os comensais.
Office blood pressure, heart rate and A(-597)G interleukin-6 gene polymorphism in apparently healthy Czech middle-aged population
Authors: Vašků A , Souček M , Goldbergová M , Vácha J
Published: June 2023

The aim of the study was to assess the association between promoter polymorphism [A(-596)G] in interleukin-6 gene and office systolic and diastolic blood pressures, and the heart rate (HR) in apparently healthy Czech subjects. Furthermore, we evaluated the possible influence of gender, BMI and smoking on these supposed associations. An age-matched (40-50 years) and gender-matched (F/M=81/89) sample of apparently healthy Czech subjects (n=170, F/M=81/89) without hypertension, other cardiovascular diseases or diabetes was examined. The A(-596)G Il-6 gene polymorphism was detected by the PCR method. No differences in genotype distribution and/or allelic frequency was found between groups with lower systolic blood pressure (£ 122 mm Hg) and higher systolic blood pressure (> 122 mm Hg). Similarly, no differences in the IL-6 polymorphism were found between lower (£ 86 mm Hg) and higher (> 86 mm Hg) diastolic blood pressure groups. However, we proved a significant increase of genotypes AG+GG as well as the allele (‑596)G in higher (>78 beats/min) heart rate group. The genotypes AG+GG represent significantly higher relative risk for higher HR frequency, especially in women. Among lean persons with a low heart rate frequency, fewer AG+GG genotypes were determined than among any other subjects. The genotypes AG+GG are more frequent in non-smoking persons with higher HR compared to non-smoking subjects with lower HR, especially in women. Gender, BMI and smoking substantially modify the distribution of A(-596)G Il-6 gene polymorphism in apparently healthy persons with lower or higher heart rate.
Serum alpha-glutathione S-transferase as a sensitive marker of hepatocellular damage in patients with cystic fibrosis
Authors: Šídlová K , Skalická V , Kotaška K , Pechová M , Chada M , Bartošová J , Hříbal Z , Nevoral J , Vávrová V , Průša R
Published: June 2023

The aim of the study was to evaluate serum a-glutathione S-transferase (s-GSTA) levels in patients with cystic fibrosis (CF) and to compare s-GSTA with other liver function tests and with a hepatic ultrasound scan (US). The cytosolic enzyme, a-glutathione S-transferase is predominantly found in the liver and is distributed uniformly in the liver tissue. In our study s-GSTA levels were measured in 37 CF patients aged 1 to 28 years (mean age 10.4 years, 24 males). The control group consisted of 27 patients aged 2 to 17 years (mean age 8.5 years, 18 males). The presence of hepatobiliary abnormalities was assessed by clinical examination, ultrasound scan, s-GSTA, and conventional liver enzymes: alanine aminotransferase (ALT), alkaline phosphatase (ALP), aspartate aminotransferase (AST) and g-glutamyl transferase (GMT). The calculated 5-95 % range of s-GSTA for the control group was 0.098-2.54 mg/l, for the CF group 0.43-9.76 mg/l. Mean s-GSTA level in the control group was 1.55 mg/l (S.D.=1.57), and 2.05 mg/l (S.D.=2.60) in the CF group. In the group of CF patients, the serum levels were significantly higher than in the control group (P<0.01). No significant correlation existed in the CF group between s-GSTA and conventional liver tests (ALT, AST, ALP and GMT). Four patients in the CF group had hepatobiliary abnormalities detectable by conventional liver tests, s-GSTA and US. Four patients had abnormal s-GSTA, while conventional liver tests and US were normal. One other patient had abnormal hepatic US, but normal standard liver tests and s-GSTA. The study has suggested that a raised s-GSTA level might be a marker of possible pathological changes of the hepatobiliar system in CF patients. Serum GSTA seems to be a more sensitive marker than transaminases for the monitoring of hepatocellular integrity and as an early predictor of hepatic damage.
Inhibin B, follicle stimulating hormone, luteinizing hormone, and estradiol and their relationship to the regulation of follicle development in girls during childhood and puberty
Authors: Chada M , Průša R , Bronský J , Pechová M , Lisá L
Published: June 2023

Inhibin B, produced by granulosa cells in the ovary, is a heterodimeric glycoprotein suppressing synthesis and secretion of the follicle stimulating hormone (FSH). The aim of the present study was to determine hormone profiles of inhibin B, FSH, luteinizing hormone (LH), and estradiol in girls during childhood and puberty and to evaluate whether inhibin B is a marker of follicle development. We examined the correlation between inhibin B and gonadotropins and estradiol during the first two years and across the pubertal development. Using a specific two-side enzyme-linked immunosorbent assay (ELISA), inhibin B levels were measured in the serum of 53 healthy girls divided into 8 groups according to age. In addition, serum FSH, LH, and estradiol were measured by chemiluminescent immunoassay in all serum samples. A rise in serum levels of inhibin B (55.2±7.3 ng/l, mean ± S.E.M.) and FSH (1.78±0.26 UI/l), concomitant with a moderate increment of serum LH (0.36±0.09 UI/l) and estradiol (45.8±12.2 pmol/l) concentrations was observed during the first three months of life and declined to prepubertal concentrations thereafter. A strong positive correlation between inhibin B and FSH (r = 0.48, p<0.05), LH (r = 0.68, p<0.001) and estradiol (r = 0.59, p<0.01) was demonstrated during the first 2 years of life. A rise in serum levels of inhibin B, FSH, LH, and estradiol was found throughout puberty. Inhibin B had a strong positive correlation with FSH (stage I of puberty: r = 0.64, p<0.05; stage II of puberty: r = 0.86, p<0.01), LH (I: r = 0.61, p<0.05; II: r = 0.67, p<0.05), and estradiol (II: r = 0.62, p<0.05) in early puberty. From pubertal stage II, inhibin B lost this relationship to gonadotropins and estradiol. Serum inhibin B and FSH levels increased significantly during pubertal development, with the highest peak found in stage III of puberty (133.5±14.3 ng/l), and decreased thereafter. In conclusion, inhibin B is produced in a specific pattern in response to gonadotropin stimulation and plays an important role in the regulation of the hypothalamic-pituitary-gonadal axis during childhood and puberty in girls. Inhibin B is involved in regulatory functions in developing follicles and seems to be a sensitive marker of ovarian follicle development.
Plasma levels of dosulepine and heart electric field
Authors: Kitzlerová E , Paclt I , Slavíček J , Pišvejcová K , Anders M , Dohnalová A , Balíková M
Published: June 2023

Antidepressants, particularly tricyclic (TCA) antidepressants, may have cardiotoxic effects, such as cardiac arrhythmias, especially in patients with cardiovascular diseases. For most of TCA, no exact correlation between dosage, plasma levels and changes of ECG parameters of standard ECG has been found. So far, no relationship between dosulepine plasma levels and heart electric field parameters has been studied. We selected 18 female outpatient subjects diagnosed with recurrent depressive disorders, currently in the remission phase (HAMD < 10), without any cardiovascular disease. Patients were treated with daily dosulepine doses of 25-125 mg for 4-8 weeks. 30 heart electric field parameters were analyzed by Cardiag 128.1 diagnostic system as part of BSPM (Body Surface Potential Mapping). Acquired data were correlated with dosulepine plasma levels by means of Spearman's rank order correlation test. Four ECG parameters showed a significant correlation with dosulepine plasma levels: QRS axis deviation in frontal plane (p=0.01), DIAM 40 max (p<0.05), QRS-STT angle in transversal and left sagittal plane (p<0.05). The demonstrated changes confirmed dosulepine influence on the early myocardium depolarization phase and the correlation of this effect with dosulepine dose (its plasma concentration). The higher the dosulepine level, the more marked are the changes of the QRS-STT angle in transversal and sagittal planes and the changes in the QRS axis deviation in frontal plane. Repeatedly recorded changes in the heart electric field were dosulepine-specific and dependent on its plasma levels.
A dampening effect of pulse interval variability on blood pressure variations with respect to primary variability in blood pressure during exercise
Authors: Honzíková N , Krtička A , Nováková Z , Závodná E
Published: June 2023

The correlation between baroreflex sensitivity (BRS) and the spectrum component at a frequency of 0.1 Hz of pulse intervals (PI) and systolic blood pressure (SBP) was studied. SBP and PI of 51 subjects were recorded beat-to-beat at rest (3 min), during exercise (0.5 W/kg of body weight, 9 min), and at rest (6 min) after exercise. BRS was determined by a spectral method (a modified alpha index technique). The subjects were divided into groups according to the spectral amplitude of SBP at a frequency of 0.1 Hz. The following limits of amplitude (in mm Hg) were used: very high ≥ 5.4 (VH); high 5.4 > H ≥ 3 (H); medium 3 > M ≥ 2 (M), low < 2 (L). We analyzed the relationships between 0.1 Hz variability in PI and BRS at rest, during the exercise and during recovery in subgroups VH, H, M, L. The 0.1 Hz variability of PI increased significantly with increasing BRS in each of the groups with identical 0.1 Hz variability in SBP. This relationship was shifted to the lower values of PI variability at the same BRS with a decrease in SBP variability. The primary SBP variability increased during exercise. The interrelationship between the variability of SBP, PI and BRS was identical at rest and during exercise. A causal interrelationship between the 0.1 Hz variability of SBP and PI, and BRS was shown. During exercise, the increasing primary variability in SBP due to sympathetic activation was present, but it did not change the relationship between variability in pulse intervals and BRS.
Age-Dependent Effects of Remote Preconditioning in Hypertensive Rat Hearts are Associated With Activation of RISK Signaling
Authors: FARKAŠOVÁ V , KINDERNAY L , FERKO M , RAJTÍK T , SZOBI A , RAVINGEROVÁ T
Published: June 2023

Remote ischemic preconditioning (RIPC) represents one of the forms of innate cardioprotection. While being effective in animal models, its application in humans has not been always beneficial, which might be attributed to the presence of various comorbidities, such as hypertension, or being related to the confounding factors, such as patients’ sex and age. RIPC has been shown to mediate its cardioprotective effects through the activation of Reperfusion Injury Salvage Kinase (RISK) pathway in healthy animals, however, scarce evidence supports this effect of RIPC in the hearts of spontaneously hypertensive (SHR) rats, in particular, in relationship with aging. The study aimed to investigate the effectiveness of RIPC in male SHR rats of different age and to evaluate the role of RISK pathway in the effect of RIPC on cardiac ischemic tolerance. RIPC was performed using three cycles of inflation/deflation of the pressure cuff placed on the hind limb of anesthetized rats aged three, five and eight months. Subsequently, hearts were excised, Langendorff-perfused and exposed to 30-min global ischemia and 2-h reperfusion. Infarct-sparing and antiarrhythmic effects of RIPC were observed only in three and five months-old animals but not in eight months-old rats. Beneficial effects of RIPC were associated with increased activity of RISK and decreased apoptotic signaling only in three and five months-old animals. In conclusion, RIPC showed cardioprotective effects in SHR rats that were partially age-dependent and might be attributed to the differences in the activation of RISK pathway and various aspects of ischemia/reperfusion injury in aging animals.
Analysis of Signaling Pathways of Necroptotic and Pyroptotic Cell Death in the Hearts of Rats With Type 2 Diabetes Mellitus
Authors: HORVÁTH C , JARABICOVÁ I , RAJTÍK T , BARTOŠOVÁ L , FERENCZYOVÁ K , KALOČAYOVÁ B , BARTEKOVÁ M , SZOBI A , ADAMEOVÁ A
Published: June 2023

Diabetes mellitus is known to produce various cell-damaging events and thereby underlie heart dysfunction and remodeling. However, very little is known about its inflammation-associated pathomechanisms due to necrosis-like cell death. For this purpose, we aimed to investigate signaling pathways of necroptosis and pyroptosis, known to produce plasma membrane rupture with the resultant promotion of inflammation. One-year old Zucker diabetic fatty (ZDF) rats did not exhibit significant heart dysfunction as revealed by echocardiographic measurement. On the other hand, there was a decrease in heart rate due to diabetes. Immunoblotting analysis showed that the left ventricles of ZDF rats overexpress neither the main necroptotic proteins including receptor-interacting protein kinase 3 (RIP3) and mixed lineage domain kinase-like pseudokinase (MLKL), nor the pyroptotic regulators including NLR family pyrin domain containing 3 protein (NLRP3), caspase-1, interleukin-1 beta (IL-1β and the N-terminal gasdermin D (GSDMD-N). On the other hand, the increased activation of the RIP3 kinase due to phosphorylation was found in such hearts. In summary, we showed for the first time that the activation of cardiac RIP3 is upregulated due to disturbances in glucose metabolism which, however, did not proceed to necrosis-like cell death. These data can indicate that the activated RIP3 might also underlie other pleiotropic, non-necroptotic signaling pathways under basal conditions.
Glycosylated Fibronectin as a wide-spectrum biomarker in pregnancy
Authors: Karoutsos D. , Fasoulakis Z. , Michala S. , Stefanidis K. , Antsaklis P.
Published: June 2023

Glycosylated Fibronectin (GFN), a glycoprotein involved in cell adhesion and migration, has been implicated in several physiological and pathological processes. Current literature suggests its altered glycosylation patterns might be associated with various pregnancy complications with recent studies providing new empirical evidence from a cohort study involving more than 2,000 pregnant women. The aim of this review, is to summarize the association of GFN levels and its glycosylation patterns with various outcomes including preeclampsia, gestational diabetes mellitus (GDM), spontaneous preterm birth, and intrauterine growth restriction (IUGR) in order to identify potential patterns of the use of GFN as a biomarker for predicting a wide range of pregnancy-related complications, and to provide evidence for further investigation on new diagnostic tools and therapeutic strategies.