bluuebunny/crossref_metadata_2025 huggingface dataset:
Perancangan Chatbot untuk Layanan Informasi Sekolah (Studi Kasus SMK Dwi Sejahtera Pekanbaru)
Authors: Ivan Gunawan  , Hadi Asnal  , Muhammad Nur Cahyadi  , Zaki Mubarok G
Published: December 2022

Abstrak

Seiring berkembangnya teknologi saat ini, tentunya ini sangat memberikan kemudahan bagi masyarakat dalam mencari informasi. Dalam mencari informasi terkait sekolah yang akan dituju, biasanya calon siswa akan mendatangi langsung sekolah yang bersangkutan untuk mendapatkan informasi terkait syarat pendaftaran untuk masuk ke sekolah tersebut. Informasi tersebut biasanya didapat dari madding sekolah, brosur, staff guru, dan lainnya. Pada penelitian ini, chatbot digunakan untuk memenuhi kebutuhan informasi SMK Dwi Sejahtera. Chatbot adalah system layanan informasi yang berfungsi untuk memberikan kebutuhan informasi pada system layanan service. System Chatbot yang digunakan adalah system chatbot  berbasis text. Dengan menggunakan Artificial Intelligence Markup Language (AIML). AIML digunakan untuk memberikan jawaban yang relevan yang sesuai dengan pola kalimat yang telah ditemukan dalam Bahasa manusia agar tidak terjadi kesalahan saat user berinteraksi dengan bot. system ini dibangun dengan tujuan agar siswa baru yang ingin mendaftar atau hanya sekedar ingin memperoleh informasi di SMK Dwi Sejahtera kemudahan dalam berinteraksi langsung dengan bot di kolom chat tanpa harus datang menemui staff yang bersangkutan.

 

Abstract

Along with the development of technology today, of course, this is very easy for the public to find information. In looking for information related to the school to be targeted, usually prospective students will go directly to the school concerned to get information related to the registration requirements for admission to the school. This information is usually obtained from school madding, brochures, teacher staff, and others. In this study, chatbots were used to meet the information needs of SMK Dwi Sejahtera. Chatbot is an information service system that functions to provide information needs in the service system. The Chatbot system used is a text-based chatbot system. By using Artificial Intelligence Markup Language (AIML). AIML is used to provide relevant answers that match the sentence patterns that have been found in human language so that no errors occur when the user interacts with the bot. This system was built with the aim that new students who want to register or just want to get information at SMK Dwi Sejahtera are easy to interact directly with bots in the chat column without having to come to see the staff concerned.
A Case Exhibiting Late, Postoperative, Toric Intraocular Lens Rotation
Authors: Kim Hyun Woo , Lee Sang Hee , Lee Chong Eun , Lee Kyoo Won , Seo Sam
Published: December 2022

Purpose: We present a case of spontaneous toric intraocular lens (IOL) rotation in the late postoperative period (after 10 months).Case summary: A 44-year-old male underwent phacoemulsification and placement of an IOL (AcrySof IQ Toric, Alcon Laboratories Inc., Fort Worth, FL, USA) in the right eye. The preoperative best corrected visual acuities (BCVAs) were 0.2 in the right eye and 0.3 in the left eye, and the corneal astigmatisms -2.25 × 175° and -2.25 × 178°. Ten months later, the astigmatic IOL axis was 85° (the initial [correct] value). The BCVA after surgery was 1.0. At 11 months postoperatively, the patient presented with a sudden decrease in visual acuity in the right eye. The IOL had rotated 50° clockwise; we decided to reposition it. A capsular tension ring had been placed during surgery. The IOL was re-aligned but rotated again 1 week later. We replaced the IOL with a monofocal non-toric IOL (enVista MX60, Bausch & Lomb, Rochester, NY, USA).Conclusions: Severe toric IOL rotation is a late postoperative complication.
A Case of Optic Disc Pigmentation in a Nevus of Ota Patient
Authors: Kim Min-Ji , Lee Eun Jung , Han Jong Chul , Kee Chang Won
Published: December 2022

Purpose: To report a case of optic disc pigmentation in a nevus of Ota patient.Case summary: A 56-year-old female was referred to our clinic with suspected glaucoma in the left eye. She had no previous history of ocular surgery or treatment. The best corrected visual acuity and intraocular pressure were 0.7 and 15 mmHg in both eyes, respectively. Slit lamp microscopy demonstrated nevus of Ota in the right sclera and increased iris pigmentation. Gonioscopy demonstrated increased trabecular meshwork pigmentation in the right eye. Fundus examination showed pigmentation of the choroid and optic disc in the right eye; choroidal thickness of the right eye was greater than that of the left eye on optical coherence tomography. However, there were no glaucomatous changes in the right eye. There were no specific findings in the left eye.Conclusions: To the best of our knowledge, this was the first reported case of optic disc pigmentation in a Korean nevus of Ota patient.
Effects of Perioperative Ketorolac Tromethamine on Intraocular Pressure in Glaucoma Patients Undergoing Cataract Surgery
Authors: Joo Sungjun , Baek Sung Uk
Published: December 2022

Purpose: To identify the effects of 0.45% ketorolac tromethamine on intraocular pressure (IOP) after cataract surgery in glaucoma patients.Methods: A retrospective chart review of open angle glaucoma patients and controls who underwent cataract surgery (perfomed by a single surgeon) was conducted. Topical ketorolac was applied from the day before surgery until 1 month postoperatively. IOP and anterior chamber (AC) inflammation were assessed preoperatively and at 1 day, 1 month, and 3 months postoperatively. The incidence of IOP spikes was also measured. For comparative analysis, glaucoma patients were divided into ketorolac (G+K+) and non-ketorolac (G+K-) groups, while non-glaucoma patients were divided into G-K+ and G-K- groups.Results: A total of 243 eyes (243 patients) were enrolled. Among glaucoma patients, the initial postoperative IOP increase and IOP at 3 months postoperatively were lower for the G+K+ than G+K- group. In the G+K+ group, IOP remained low at 1 and 3 months postoperatively, while in the G+K- group, IOP did not change significantly compared to the preoperative values. Among non-glaucoma patients, there were no differences in IOP change until 3 months postoperatively between the G-K+ and G-Kgroups. AC inflammation was significantly lower at 1 week in the G+K+ than G+K- group. The incidence of IOP spikes during the first 3 months postoperatively was lower in the G+K+ than in the G+K- group.Conclusions: Ketorolac had a positive effect on IOP after cataract surgery and allowed for a lower IOP to be maintained in glaucoma patients. Topical ketorolac may be used to prevent IOP elevation after cataract surgery in patients with advanced glaucoma or at high risk for severe AC inflammation.
Automated Detection of Horizontal Strabismus and Home Control Evaluation Using a Mobile Phone App
Authors: Lee Donghyeon , Kim Hyuna
Published: December 2022

Purpose: To evaluate the reliability, validity, and usability of a mobile phone app that captures facial images to identify strabismus.Methods: We enrolled patients who visited our pediatric strabismus clinic and provided consent for participation in the study. The facial photographs of the patients were automatically captured by the app. The app used the photographs to identify ocular misalignment based on the comparison of the positions of the corneal reflex and limbus of both eyes. The results from the app were compared to the physician’s diagnosis. Intraclass correlation coefficients were used to assess the test-retest and interrater reliability of the app. Additionally, the guardians captured photographs of the patients through this app for 1 month at home to evaluate the frequency of manifest exotropia at home. And the results were compared to those of other strabismus control scales.Results: A total of 103 patients were enrolled and 10 patients were enrolled for the home control test. Based on the physician’s diagnosis, the sensitivity, specificity, positive predictive value, and negative predictive value of the app were 74.6%, 87.5%, 90.4%, and 68.6%, respectively. The interclass correlation coefficients for inter-rater and test-retest reliability were 0.801 (p = 0.011) and 0.828 (p < 0.001), respectively. The frequency of intermittent exotropia recorded by the app at home showed a strong positive correlation with other control scales (rho > 0.770, p = 0.009).Conclusions: This mobile phone app is easily accessible and useful for the rapid determination and recording of strabismus, particularly in uncooperative patients. Also, this app may be used as a reliable indicator of the frequency of manifest strabismus at home.
Process Simulation & Sensitvity Analysis of Cumene Production from an Integrated Alkylation and Transalkylation Reaction
Authors: Hazmi Hilman Ali
Published: December 2022

Cumene is a very important petrochemical commodity, mainly to produce phenol and acetone. The overall growth rate for cumene capacity has been healthy, averaging slightly less than 3.5 % per year to reach 18 million metric tons per year in 2017. The purpose of this study is to generate a steady-state process simulation using ASPEN HYSYS version 10 to produce a small capacity of 10 ton/h of cumene with 99.99 wt % product purity. An alkylation reaction of benzene with propylene is carried out for producing cumene by using a zeolites catalyst as modeled by Badger technology. Transalkylation is also integrated into the system for eliminating unwanted products such as p-diisopropyl benzene. The proposed simulation flowsheet provides a good convergence overall result. The preliminary utility consumption obtained from the simulation consists of approximately 0.0418 kton/h of steam, 1.22 kton/h of cooling water, and 450 kW of electrical duty. Optimization is carried out in the simulation by conducting a sensitivity analysis study to find the optimum operating conditions of the alkylation reactor with a dimension of 1.3 m diameter and 4 m of length. The result shows that at an optimum value of B/P molar ratio of 7, reactant temperature of 170 oC, and reactant pressure of 3 MPa, the selectivity of cumene obtained is at a high value of 0.9446, while the percentage conversion of propylene to cumene obtained is at a high value of 99.99 %.
PARP Inhibitors as a Novel Treatment Strategy for Patients with BRCA-Mutated Metastatic Breast Cancer
Authors: Rygiel Katarzyna
Published: December 2022

Inhibitors of poly(ADP-ribose) polymerase (PARP), such as olaparib and talazoparib, have recently been approved as therapies for BRCA-mutated human epidermal growth factor receptor 2 (HER2)-negative metastatic breast cancer (BC). In addition, olaparib, as well as rucaparib and niraparib, have received approval for treatment of patients with BRCA-mutated or platinum-sensitive recurrent ovarian cancer.

The treatment efficacy of PARP inhibitors is higher in case of malignancies that harbour deleterious germline or somatic BRCA mutations compared to BRCA wild-type tumours. Consequently, BRCA mutations or intrinsic tumour sensitivity to platinum therapy are considered indicators of impaired ability to repair DNA double-strand breaks via homologous recombination.

However, not all BRCA-mutated cancer patients benefit from PARP inhibitors. In contrast, for some patients with wild-type BRCA or platinum-resistant tumours, the PARP inhibitors may still offer some therapeutic advantages. Therefore, there is a need to determine additional biomarkers to more precisely select patients without deleterious BRCA mutations, who may be eligible for treatment with PARP inhibitors.

The main objective of this mini-review is to present the main mechanisms of action of PARP inhibitors and briefly summarise the clinical trials leading to their approval in treatment of BRCA-mutated, HER2-negative metastatic BC. In addition, this article discusses the efficacy, safety, and resistance to PARP inhibitors in women with metastatic BC.
The Anticancer Power of the Immune System – New Perspectives for Patients with Triple-Negative Breast Cancer
Authors: Rygiel Katarzyna
Published: December 2022

Triple-Negative Breast Cancer (TNBC) represents a heterogeneous disease that includes different subtypes and accounts for approximately 20% of all breast cancers (BC). TNBC is oestrogen receptor-negative, progesterone receptor-negative, and human epidermal growth factor receptor 2-negative. In addition, the androgen receptor is expressed in roughly 10–32% of TNBC cases. TNBC is characterised by worse outcomes, including higher risks of relapse and visceral crisis compared to other BC subtypes (especially during the first 2 years post BC diagnosis). Programmed death-ligand 1 (PD-L1) is widely expressed on the surface of lymphocytes, monocytes, natural killer cells, macrophages, and some other cells. Moreover, PD-L1 expression has been explored in different types of cancer (e.g., malignant melanoma, non-small cell lung cancer, renal cell carcinoma, and colon cancer). Due to limited treatment options for TNBC, there is an urgent need for the development of novel diagnostic and therapeutic strategies. To fulfil this unmet need, different approaches, including immunotherapy, have been investigated in clinical studies (with the goal of matching therapies with specific BC subtypes). This article discusses some diagnostic considerations relevant to patients with TNBC (focussing on advanced or metastatic disease). It
Pengendalian Persediaan Welding Gas Arcal-21 Dengan Metode EOQ dan Min-Max Pada PT. Beton Perkasa Wijaksana
Authors: Sari Santika , Saputro Annisa Putriana
Published: December 2022

PT. Beton Perkasa Wijaksana mengalami penurunan penjualan produk yang cukup drastis sehingga membuat overload bahan baku pada gudang. Penyebabnya karena PT. Beton Perkasa Wijaksana kehilangan kerjasama dengan beberapa perusahaan asing yang sebelumnya sudah menjadi pelanggan tetap yang membeli produk-produk dari PT Beton Perkasa Wijaksana ini. Maka dari, itu perlu diadakannya pengendalian persediaan bahan baku untuk mengoptimalkan persediaan yang ada di gudang. Tujuan penelitian ini adalah untuk mengetahui pengendalian persediaan dengan nilai terbaik dari perbandingan kedua metode, yaitu metode EOQ dan metode Min-Max pada PT. Beton Perkasa Wijaksana, sehingga persediaan bahan baku yang ada di gudang bisa digunakan dengan optimal. Hasil penelitian menunjukkan nilai safety stock, minimum inventory, maximum inventory, dan total inventory cost yang memiliki nilai lebih kecil adalah metode EOQ dengan meminimumkan 8% dari metode Min-Max. Dengan demikian terpilih metode yang lebih baik adalah Economic Order Quantity (EOQ) dengan cara meminimumkan biaya langsung penyimpanan persediaan dan biaya kebalikannya (inverse cost) pemesanan persediaan.
Analisis Percepatan Waktu Dan Biaya Dengan Metode Time Cost Trade Off (TCTO)
Authors: Nathasia Cut Adinda , Budiman Johan , Norman Norman
Published: December 2022

Proyek pembangunan jalan tol merupakan proyek infrastruktur strategis, dikarenakan merupakan proyek strategis Nasional sehingga pemerintah membuat Program Percepatan Pembangunan Jalan Tol sepanjang lebih kurang 1100 km agar dapat segera difungsikan

Salah satu metode yang digunakan untuk melakukan analisa percepatan proyek tersebut adalah Analisis Pertukaran Waktu dan Biaya (Time Cost Trade Off Analysis) yang diolah dari data sekunder dimana bertujuan untuk  mempercepat waktu penyelesaian proyek dan menganalisis sejauh mana waktu dapat dipersingkat dengan penambahan biaya yang minimum terhadap kegiatan yang dapat dipercepat waktu pekerjaannya. Alternatif yang digunakan untuk metode tersebut adalah dengan penambahan jam kerja lembur

Setelah menganalisa proyek dengan metode Time Cost Trade Off, didapatkanlah percepatan penyelesaian proyek menjadi 123 hari dari waktu normal 158 hari dengan efisiensi waktu proyek sebesar 19% dan juga efisiensi biaya optimum sebesar 2%.

Kata kunci : Jalan Tol, Percepatan, Metode Time Cost Trade Off, Hubungan Biaya Terhadap Waktu
Sistem Informasi Manajemen Organisasi Pemuda Peduli Anak Yatim (Popay) Berbasis Website Responsive
Authors: Rinaldi Syahwan , Rahmawati Diah , Nugroho Asep Hardiyanto
Published: December 2022

Popay (Pemuda Peduli Anak Yatim) adalah organisasi non-profit yang berkegiatan mengumpulkan, mengelola, dan membagikan bantuan kepada anak yatim berupa uang tunai dan bahan pokok untuk kebutuhan sehari-hari. Selama ini proses pencatatan dan pendataan yang dilakukan oleh organisasi menggunakan model tradisional, dimana semua pencatatan data dan transaksi masih menggunakan kertas dan rentan sekali kehilangan maupun kerusakan karena manajemen arsip yang tidak dikelola dengan baik. Untuk meningkatkan efektifitas dan efisiensi dalam pengelolaan data di organisasi Popay, maka dibuatlah sistem informasi pengolahan data berbasis website. Pada tahap pembuatan website ini digunakan metode pengembangan Rapid Aplication Development (RAD). Sistem ini didesain responsive sehingga dapat beradaptasi secara optimal diperangkat apapun. Pentingnya penyesuaian desain tampilan dengan layar perangkat yang digunakan agar dapat memberikan kenyamanan kepada pengurus organisasi saat melakukan pengisian data anak yatim dari rumah ke rumah, juga bagi para donatur yang ingin mengakses informasi tanpa membutuhkan perangkat khusus seperti laptop. Dengan adanya sistem informasi manajemen pada organisasi Popay, membantu pengurus organisasi dalam pengelolaan data secara sistematis dan memudahkan masyarakat juga para donatur untuk mendapatkan informasi kegiatan dan laporan penggunaan dana.
Impaired Expression of Mu- and Kappa-Opioid Receptor mRNA in the Midbrain of Rats with Prenatal Alcohol Intoxication
Authors: Kokhan V. S. , Anokhin P. K. , Pakhlova E. P. , Sarycheva N. Yu. , Shamakina I. Yu.
Published: December 2022

Disruption of normal epigenetic reprogramming during the prenatal period under the influence of exogenous factors affects fetus development and adult phenotype formation. The mechanisms through which determinants, such as maternal alcohol intake, contribute to the formation of an alcohol-vulnerable phenotype later in life still remain unclear. In this paper, we suggest that alteration in the reinforcing properties of ethanol in prenatally alcohol-exposed subjects may be associated with transcriptional dysregulation of the brain opioid receptor genes. We compared voluntary alcohol intake and levels of mRNA coding for μ- (MOP) and κ-opioid (KOP) receptors in the mesolimbic areas of adult male offspring of the female Wistar rats having received 10% ethanol as the only source of liquid throughout pregnancy or water (control). We found that prenatally alcohol exposed rats had higher alcohol preference on PND60 (free-choice paradigm) and lower mRNA expression for both MOP and KOP in the midbrain compared to the control. This suggests a potential link between prenatal alcohol, dysfunction of the brain opiate system and adult vulnerability for alcohol use disorder.
Content of Biologically Active Substances in the Musk of Siberian Musk Deer Depending on Food Spectrum of Animal Nutrition
Authors: Zubalii A. M. , Nesterov M. S. , Karkischenko V. N. , Khvostov D. V. , Ageldinov R. A. , Ognev S. V.
Published: December 2022

The content of biologically active substances in the gland secretion of Siberian musk deer obtained in vivo was studied by gas chromatography-mass spectrometry using derivatization by silylation. The musk chemical composition of animals held under natural conditions and in captivity was compared. The food spectrum of Siberian musk deer was found to affect the content of biologically active components in the musk, primarily of androsteroid substances. The results of evaluating the content of musk components exhibiting the most pronounced biological effects are presented. An increase in the diversity of food spectrum was established to improve the qualitative composition of biologically active substances in the musk obtained from the adult males of Siberian musk deer held in captivity.
Evaluation of the Efficiency of Phenol-Containing Complexes Extracted from Different Parts of Sorbus Aucuparia L. in an Oncological Experiment
Authors: Rybalkina O. Yu. , Razina T. G. , Kiseleva E. A. , Kalinkina G. I. , Isaikina N. V. , Zueva E. P. , Zhdanov V. V.
Published: December 2022

Mountain ash (Sorbus aucuparia L.) is a prominent representative of phenolic medicinal plants. A widespread and cultivated plant, it has a sufficient raw material base not only of fruits, but also of other parts of the plant (leaves, flowers); it is a promising source of biologically active complexes for the development of new medical drugs. In the work, the content of the main groups of phenolic compounds in plant extracts from fruits, leaves and flowers of S. aucuparia L. was determined. Extracts were obtained using the original technology with acidified 95% ethanol. The content of the sum of phenolic compounds was determined, as well as the content of anthocyanins, flavonoids, phenolic acids, tannins. The effect of these phenol-containing complexes on the development of transplanted tumors (Lewis lung carcinoma, lung cancer-67) and the effectiveness of cyclophosphane treatment were studied. It was revealed that the use of plant complexes leads to a significant inhibition of the development of metastases in the lungs, as well as an increase in the antitumor and anti-metastatic activity of cyclophosphane in combined treatment. The new data obtained are of interest for further study of these phenol-containing complexes in order to create drugs based on them to increase the effectiveness of chemotherapy for malignant neoplasms.
Estimation of Fly ASH Availability in a Thermal Power Plant for Cement Manufacturers
Authors: Saravanan V. , Subbiramani K. , Janardhana M.
Published: December 2022

The Indian coals are having 25 to 45% ash content and huge quantity of fly ash is being generated every day in the Indianthermal power plants. The fly ash so generated are being disposed by dry or wet mode from the power plant. The fly ashdisposed in dry mode is lifted by the cement manufacturers and the fly ash disposed in wet mode is unattended. Mostof the quantity of fly ash is collected in the ESPs. The particle size of fly ash collected in ESPs is finer compared to the flyash collected in other parts of the power plant. For this reason the cement manufacturers prefer the fly ash from ESPs.The quantity of fly ash collected in the ESPs is not directly measurable on everyday basis as there are no well proveninstrumental methods. Also the quantity of fly ash collected in ESPs fluctuates every day due to the varying load factorand coal quality. However, it is important to estimate the quantity of fly ash collected by ESPs on everyday basis so thatthe proportion of fly ash lifted by the cement manufacturers and the fly ash sent to the ash pond will be known. Presentlypower plants do not have a method to estimate the exact availability of fly ash and it is being theoretically calculated fromthe design value that the 80% of the total ash is fly ash and in that a fixed proportion (about 70% of total fly ash generated)is collected in the ESPs. However, the actual generation of fly ash would be different and this is influenced by the type ofcoal used, fineness of the input coal particles, boiler operating conditions, load factor, age of the power plant, etc. Thisuncertainty leads to disputes between cement manufacturers and the utility if there is a penalty clause in the agreementfor not completely lifting the available fly ash (as theoretically calculated by the utility). In view of this it is imperative toformulate acceptable methods for determining the actual quantity of fly ash collected in the ESPs on daily basis. In thepresent work, a simple methodology was developed to quantity the average fly ash collected in ESPs in a 210 MWe coalfired power plant on every day basis through site measurements and routine power plant data. The amount of fly ashdisposed in dry and wet mode has also been estimated through this method.
Disgerminoma en un adolescente con síndrome de Down
Authors: Peñaherrera Cepeda Gabriela , Maldonado Merino Kathia del Cisne , Maldonado Merino Estefanía
Published: December 2022

Introducción: Los tumores de las células germinales son la neoplasia maligna del ovario más prevalente en adolescentes y niñas, son detectados generalmente en estadios iniciales. No se conoce la asociación con el síndrome de Down, motivo de presentación del presente caso.
Caso Clínico: Se presenta el caso de una niña de 13 años de edad con síndrome de Down, referida por una masa supra púbica dolorosa de dos meses de evolución.
Taller diagnóstico: Los estudios de extensión detectaron un tumor a nivel pélvico dependiente de ovario izquierdo, por lo que se planificó una tumorectomía. El estudio histopatológico determinó la presencia de un tumor germinal con componente de disgerminoma y trofoblástico.
Evolución: La paciente fue prescrita con tratamiento quimioterápico, con una evolución favorable a los 16 meses de seguimiento.
Conclusión: la clínica clásica de tumores de células germinales en el síndrome de Down es poco indicativa; en la mayoría de los casos se trata de preservar la fertilidad, inclusive siendo niñas portadoras de Síndrome de Down. El seguimiento en el presente caso ha sido favorable a 16 meses.
Tratamiento radiante adyuvante del lecho quirúrgico en el cáncer de mama: a quién, cuándo y cómo hacerlo
Authors: Roldán Santiago , Guzmán Karol , Torres Marcelo , Rivero Milexys , Ricagni Leandro , Lorenzo Federico
Published: December 2022

Introducción: Actualmente existen discrepancias en cuanto a la indicación, dosis, técnica y contorneo de la sobreimpresión o aumento de dosis de irradiación sobre el lecho quirúrgico en el tratamiento adyuvante en cáncer de mama.
Propósito de la revisión: El objetivo de la revisión es presentar la evidencia disponible en sobreimpresión del lecho quirúrgico en el tratamiento de cáncer de mama. Realizamos una revisión bibliográfica en MEDLINE pubmed, se analizaron 61 estudios publicados entre enero del 2000 a enero del 2022.
Recientes hallazgos: La sobreimpresión sobre el lecho quirúrgico en la mama mejora el control local en aquellas pacientes con elementos de alto riesgo. Las diferentes técnicas disponibles son oncológicamente equivalentes. La delimitación del blanco de tratamiento debe guiarse por los clips quirúrgicos.
Conclusiones: La indicación de dicho tratamiento deberá ser evaluado por los servicios de oncología radioterápica, definiendo sus protocolos y algoritmos de acción.
PENGARUH TERAPI MUROTTAL AL-QUR’AN SURAH ARRAHMAN TERHADAP PERUBAHAN TINGKAT KECEMASAN PADA PASIEN PRE OPERASI DI RSUD DR. H. ANDI ABDURRAHMAN NOOR KABUPATEN TANAH BUMBU
Authors: Putra Farhandika , Dewy Tika Sari , Junaidi Ahmad
Published: December 2022

Kecemasan merupakan keadaan emosi yang tidak menyenangkan, melibatkan rasa takut  yang   subjektif,  rasa  tidak  nyaman  pada  tubuh,  dan  gejala  fisik serta pengalaman   manusia   yang   bersifat   universal, suatu  respon emosional yang tidak menyenangkan  penuh kekhawatiran. Tujuan penelitian ini adalah untuk mengetahui pengaruh terapi murottal AL – Qur’an Surah Arrahman terhadap Perubahan Tingkat kecemasan pada pasien pre-operasi. Jenis Penelitian ini adalah penelitian kuantitatif, dimana menggunakan desain penelitian Quasi Eksperimental dengan rancangan penelitian pretest –postest without control. Sampel pada penelitian ini adalah 20 responden,. Hasil penelitian ini menggunakan uji Wilcoxon, dan didapatkan nilai P¬-value 0,00 (<0,05) terdapat perubahan tingkat kecemasan pada pasien pre operasi. Kesimpulan dari penelitian ini adalah terdapat pengaruh Terapi Murottal Al-Qur’an surah Arrahman terhadap perubahan Tingkat kecemasan pada pasien pre operasi di rsud dr. H. Andi Abdurrahman Noor Tanah Bumbu. Saran dari penelitian ini diharapkan kepada responden menggunakan terapi murotal sebagai alternatif dalam mengurangi kecemasan yang dialami responden. Terapi Murottal Al-Qur’an lebih efektif menurunkan kecemasan dibandingkan dengan terapi lainnya sehingga dapat diterapkan sebagai terapi komplemeter untuk menurunkan kecemasan pada pasien pre operasi.
Korelasi antar Dukungan Keluarga, Efikasi Diri dan Kepatuhan Hemodialisa pada Pasien Gagal Ginjal Kronik yang Menjalani Hemodialisa
Authors: Sary Era Widia
Published: December 2022

Latar Belakang: Gagal ginjal kronik merupakan salah satu masalah kesehatan utama di dunia, dimana penyakit ini dapat menghentikan sepenuhnya fungsi ginjal. Selain transplantasi, satu-satunya pengobatan yang bisa dilakukan adalah terapi hemodialisa untuk membantu pasien bertahan hidup. Kepatuhan pasien dalam menjalani terapi merupakan hal yang penting untuk diperhatikan, jika tidak hal ini dapat memperburuk kondisi kesehatannya. Faktor yang menguatkan individu untuk patuh dalam menjalani hemodialisa adalah dukungan yang berasal dari orang terdekat seperti keluarga maupun dari dalam diri sendiri (efikasi diri). Tujuan: Penelitian ini bertujuan untuk mengetahui korelasi antar dukungan keluarga, efikasi diri dan kepatuhan hemodialisa pada pasien gagal ginjal kronik yang menjalani hemodialisa Di Rumah Sakit Islam Banjarmasin. Metode: Jenis penelitian kuantitatif menggunakan rancangan penelitian korelasional dengan sampel berjumlah 25 orang responden. Pengambilan data menggunakan lembar kuesioner dan dianalisis menggunakan uji statistik spearman rank. Hasil: Berdasarkan hasil analisis, korelasi antara dukungan keluarga dengan efikasi diri didapatkan nilai p-value = 0,002 yang berarti ada korelasi yang signifikan antara dukungan keluarga dengan efikasi diri, analisis korelasi antara dukungan keluarga dengan kepatuhan hemodialisa didapatkan nilai p-value = 0,000. Kesimpulan: Ada korelasi yang signifikan antara dukungan keluarga dengan efikasi diri pada pasien gagal ginjal kronik yang menjalani hemodialisa.
МОСКОВСКАЯ НИКОЛЬСКАЯ ОБЩИНА СЕСТЕР МИЛОСЕРДИЯ В ПАМЯТЬ КНЯГИНИ С. С. ЩЕРБАТОВОЙ И ДОКТОРА Ф. П. ГААЗА
И ЕЕ НАСТОЯТЕЛЬНИЦА Е. М. ЛОПАТИНА
Authors: Блохина Наталья Николаевна
Published: December 2022

Возникновение Никольской общины сестер милосердия в Москве связано с обстоятельствами Отечественной войны 1914 г. Как и в Крымскую войну, по царскому призыву на новые поля сражений из Москвы отправились добровольцами группы сестер милосердия. Данная община появилась как сестринское и медицинское учреждение, помогающее пострадавшим от войны мирным гражданам и воинам, в том числе нуждающимся в психиатрической помощи. Уход за больными, страдающими психическими расстройствами, становится главной заботой сестер новой общины. Имена учредителей, как и имена людей, в память которых община названа, были связаны общей традицией социальной сестринской помощи – жертвенной по своему характеру, требующей профессионализма, христианского милосердия и отреченности от собственной жизни во имя спасения жизней других.
The emergence of the Nikolskaya community of sisters of mercy in Moscow is connected with the circumstances of the Patriotic War of 1914. As in the Crimean War, at the tsar’s call, groups of sisters of mercy set off from Moscow to the new battlefields as volunteers. This community appeared as a nursing and medical institution helping civilians and soldiers affected by the war, including those in need of psychiatric help. Caring for the sick with mental disorders becomes the main concern of the sisters of the new community. The names of the founders, as well as the names of the people in whose memory the community is named, were connected by a common tradition of social nursing care - sacrificial in nature, requiring professionalism, Christian mercy and renunciation of one's own life in the name of saving the lives of others.
Negative affect increases reanalysis of conflicts between discourse context and world knowledge
Authors: Lai Vicky Tzuyin , van Berkum Jos , Hagoort Peter
Published: December 2022

Introduction

Mood is a constant in our daily life and can permeate all levels of cognition. We examined whether and how mood influences the processing of discourse content that is relatively neutral and not loaded with emotion. During discourse processing, readers have to constantly strike a balance between what they know in long term memory and what the current discourse is about. Our general hypothesis is that mood states would affect this balance. We hypothesized that readers in a positive mood would rely more on default world knowledge, whereas readers in a negative mood would be more inclined to analyze the details in the current discourse.

Methods

Participants were put in a positive and a negative mood via film clips, one week apart. In each session, after mood manipulation, they were presented with sentences in discourse materials. We created sentences such as “With the lights on you can see...” that end with critical words (CWs) “more” or “less”, where general knowledge supports “more”, not “less”. We then embedded each of these sentences in a wider discourse that does/does not support the CWs (a story about driving in the night vs. stargazing). EEG was recorded throughout.

Results

The results showed that first, mood manipulation was successful in that there was a significant mood difference between sessions. Second, mood did not modulate the N400 effects. Participants in both moods detected outright semantic violations and allowed world knowledge to be overridden by discourse context. Third, mood modulated the LPC (Late Positive Component) effects, distributed in the frontal region. In negative moods, the LPC was sensitive to one-level violation. That is, CWs that were supported by only world knowledge, only discourse, and neither, elicited larger frontal LPCs, in comparison to the condition where CWs were supported by both world knowledge and discourse.

Discussion

These results suggest that mood does not influence all processes involved in discourse processing. Specifically, mood does not influence lexical-semantic retrieval (N400), but it does influence elaborative processes for sensemaking (P600) during discourse processing. These results advance our understanding of the impact and time course of mood on discourse.
Genetic characterization of juvenile sudden cardiac arrest and death in Tuscany: The ToRSADE registry
Authors: Girolami Francesca , Spinelli Valentina , Maurizi Niccolò , Focardi Martina , Nesi Gabriella , Maio Vincenza , Grifoni Rossella , Albora Giuseppe , Bertaccini Bruno , Targetti Mattia , Coppini Raffaele , Favilli Silvia , Olivotto Iacopo , Cerbai Elisabetta
Published: December 2022

Background

Sudden cardiac arrest (SCA) in young people represents a dramatic event, often leading to severe neurologic outcomes or sudden cardiac death (SCD), and is frequently caused by genetic heart diseases. In this study, we report the results of the Tuscany registry of sudden cardiac death (ToRSADE) registry, aimed at monitoring the incidence and investigating the genetic basis of SCA and SCD occurring in subjects < 50 years of age in Tuscany, Italy.

Methods and results

Creation of the ToRSADE registry allowed implementation of a repository for clinical, molecular and genetic data. For 22 patients, in whom a genetic substrate was documented or suspected, blood samples could be analyzed; 14 were collected at autopsy and 8 from resuscitated patients after SCA. Next generation sequencing (NGS) analysis revealed likely pathogenetic (LP) variants associated with cardiomyopathy (CM) or channelopathy in four patients (19%), while 17 (81%) carried variants of uncertain significance in relevant genes (VUS). In only one patient NGS confirmed the diagnosis obtained during autopsy: the p.(Asn480Lysfs*20) PKP2 mutation in a patient with arrhythmogenic cardiomyopathy (AC).

Conclusion

Systematic genetic screening allowed identification of LP variants in 19% of consecutive patients with SCA/SCD, including subjects carrying variants associated with hypertrophic cardiomyopathy (HCM) or AC who had SCA/SCD in the absence of structural cardiomyopathy phenotype. Genetic analysis combined with clinical information in survived patients and post-mortem evaluation represent an essential multi-disciplinary approach to manage juvenile SCD and SCA, key to providing appropriate medical and genetic assistance to families, and advancing knowledge on the basis of arrhythmogenic mechanisms in inherited cardiomyopathies and channelopathies.
Identification of factors that influence the delivery fee pricing of on-demand delivery services
Authors: De Oliveira Leise Kelli , Mello Carine Aragão de , Carneiro Cheyenne Mariana de Oliveira , Costa Tatiane Eugênia Remígio da , Araújo Gracielle Gonçalves Ferreira de , Maia Maria Leonor Alves
Published: December 2022

The use of on-demand delivery services increased in Brazil during the COVID-19 pandemic, mainly by requests for ready meals. While consumers appreciate convenience, the delivery fee is a decisive factor in the purchase process. However, the delivery fee pricing strategy of on-demand delivery service platforms has not been discussed in the literature. Thus, this study aims to analyze the factors that influence the delivery fee pricing of on-demand delivery services and explores the impact of delivery fee strategies on the remuneration of couriers. We collected data from three leading on-demand delivery service platforms regarding product type, order price, service fee, delivery fee, order day, order time, waiting time, and distance. As a result, our database comprises 1,440 orders in 12 Brazilian municipalities. A linear regression model was estimated to identify the factors influencing the delivery fee pricing considering different product types. Findings showed that product type has a diverse effect on delivery fee pricing. Moreover, distance, regardless of the product type, positively influences the delivery fee. The delivery fee of the ready meals is affected by the service fee, waiting time, order day, and order time. Furthermore, the waiting time and order day affect the delivery fee of supermarket and bakery products and beverages. Finally, the delivery fee of medical products is influenced by order day and time. Findings can be helpful for the pricing strategy of on-demand delivery services.
System-level factors influencing refugee women's access and utilization of sexual and reproductive health services: A qualitative study of providers’ perspectives
Authors: Vu Milkie , Besera Ghenet , Ta Danny , Escoffery Cam , Kandula Namratha R. , Srivanjarean Yotin , Burks Amanda J. , Dimacali Danielle , Rizal Pabitra , Alay Puspa , Htun Cho , Hall Kelli S.
Published: December 2022

Refugee women have poor outcomes and low utilization of sexual and reproductive health (SRH) services, which may be driven by access to and quality of SRH services at their resettled destinations. While healthcare providers offer valuable insights into these topics, little research has explored United States (U.S.) providers' experiences. To fill this literature gap, we investigate U.S. providers' perspectives of healthcare system-related factors influencing refugee women's access and utilization of SRH services. Between July and December 2019, we conducted in-depth, semi-structured interviews with 17 providers serving refugee women in metropolitan Atlanta in the state of Georgia (United States). We used convenience and snowball sampling for recruitment. We inquired about system-related resources, facilitators, and barriers influencing SRH services access and utilization. Two coders analyzed the data using a qualitative thematic approach. We found that transportation availability was crucial to refugee women's SRH services access. Providers noted a tension between refugee women's preferred usage of informal interpretation assistance (e.g., family and friends) and healthcare providers’ desire for more formal interpretation services. Providers reported a lack of funding and human resources to offer comprehensive SRH services as well as several challenges with using a referral system for women to get SRH care in other systems. Culturally and linguistically-concordant patient navigators were successful at helping refugee women navigate the healthcare system and addressing language barriers. We discussed implications for future research and practice to improve refugee women's SRH care access and utilization. In particular, our findings underscore multilevel constraints of clinics providing SRH care to refugee women and highlight the importance of transportation services and acceptable interpretation services. While understudied, the use of patient navigators holds potential for increasing refugee women's SRH care access and utilization. Patient navigation can both effectively address language-related challenges for refugee women and help them navigate the healthcare system for SRH. Future research should explore organizational and external factors that can facilitate or hinder the implementation of patient navigators for refugee women's SRH care.
Follow-up study of neuropsychological scores of infant patients with cobalamin C defects and influencing factors of cerebral magnetic resonance imaging characteristics
Authors: Chen Tao , Sui Chaofan , Lin Suna , Guo Bin , Wang Yuanyuan , Yang Linfeng
Published: December 2022

Purpose

The purpose of this study was to investigate whether baseline cerebral magnetic resonance imaging (MRI) characteristics could predict therapeutic responsiveness in patients with cobalamin C (cblC) defects.

Materials and methods

The cerebral MRI results of 40 patients with cblC defects were evaluated by a neuroradiologist. Neuropsychological scores and imaging data were collected. Neuropsychological tests were performed before and after standardized treatment.

Results

Thirty-eight patients initially underwent neuropsychological testing [developmental quotient (DQ)]. CblC defects with cerebellar atrophy, corpus callosum thinning and ventricular dilation had significantly lower DQs than those without (P < 0.05). Through a multivariate linear stepwise regression equation after univariate analysis, ventricular dilation was the most valuable predictor of lower DQs. Thirty-six patients (94.7%) underwent follow-up neuropsychological testing. The pre- and post-treatment DQ values were not significantly different (Z = −1.611, P = 0.107). The post-treatment DQ classification (normal, moderately low, or extremely low) showed nearly no change compared to the pretreatment DQ classification (k = 0.790, P < 0.001).

Conclusion

Ventricular dilation, cerebral atrophy and corpus callosum thinning are the main MRI abnormalities of cblC defects, and these manifestations are significantly correlated with delayed development in children. MRI findings can be considered an important tool for determining the severity of cblC defects.
Exosomal long non-coding RNAs: novel molecules in gastrointestinal cancers’ progression and diagnosis
Authors: Roshani Mohammad , Baniebrahimi Ghazaleh , Mousavi Mahboubeh , Zare Noushid , Sadeghi Reza , Salarinia Reza , Sheida Amirhossein , Molavizadeh Danial , Sadeghi Sara , Moammer Farzaneh , Zolfaghari Mohammad Reza , Mirzaei Hamed
Published: December 2022

Gastrointestinal (GI) cancers arise in the GI tract and accessory organs, including the mouth, esophagus, stomach, liver, biliary tract, pancreas, small intestine, large intestine, and rectum. GI cancers are a major cause of cancer-related morbidity and mortality worldwide. Exosomes act as mediators of cell-to-cell communication, with pleiotropic activity in the regulation of homeostasis, and can be markers for diseases. Non-coding RNAs (ncRNAs), such as long non-coding RNAs (lncRNAs), can be transported by exosomes derived from tumor cells or non-tumor cells. They can be taken by recipient cells to alter their function or remodel the tumor microenvironment. Moreover, due to their uniquely low immunogenicity and excellent stability, exosomes can be used as natural carriers for therapeutic ncRNAs in vivo. Exosomal lncRNAs have a crucial role in regulating several cancer processes, including angiogenesis, proliferation, drug resistance, metastasis, and immunomodulation. Exosomal lncRNA levels frequently alter according to the onset and progression of cancer. Exosomal lncRNAs can therefore be employed as biomarkers for the diagnosis and prognosis of cancer. Exosomal lncRNAs can also monitor the patient’s response to chemotherapy while also serving as potential targets for cancer treatment. Here, we discuss the role of exosomal lncRNAs in the biology and possible future treatment of GI cancer.
Severe toxic rhabdomyolysis under combined palbociclib and simvastatin treatment: A case report
Authors: Poumeaud François , Fontanier Anna , Dion Jérémie , Mathevet Quentin , Cointault Olivier , Uro-Coste Emmanuelle , Marty Céline , Dalenc Florence , Girardie Pierre , Rataboul Anaïs
Published: December 2022

We report the fourth described case of severe toxic rhabdomyolysis occurring in an 81-year-old woman caused by the concomitant administration of palbociclib taken at the usual dosage (125 mg per day) and simvastatin. To the best of our knowledge, this is the first reported case successfully treated by plasma exchanges, with complete functional recovery within two months. The severity of this case justifies further consideration of pharmacokinetic interactions between palbociclib or other CDK-4-6 inhibitors and statins, which potentially increase the risk of an adverse event.
Global research status and frontiers on microvascular invasion of hepatocellular carcinoma: A bibliometric and visualized analysis
Authors: He Tao , Zou Jieyu , Sun Ke , Yang Juan , Lei Tingting , Xu Lin , Liu Jinheng , Yin Sineng , Li Guangkuo
Published: December 2022

Introduction

Over the past decade, several studies on the microvascular invasion (MVI) of hepatocellular carcinoma (HCC) have been published. However, they have not quantitatively analyzed the remarkable impact of MVI. Therefore, a more comprehensive understanding of the field is now needed. This study aims to analyze the evolution of HCC-MVI research and to systematically evaluate the scientific outputs using bibliometric citation analysis.

Methods

A systematic search was conducted on the Web of Science Core Collection on 2 May 2022 to retrieve studies on HCC-MVI published between 2013 and 2022. Then, a bibliometric analysis of the publications was performed using CiteSpace, VOSviewer, and other visualization tools.

Results

A total of 1,208 articles on HCC MVI were identified. Of these, China (n = 518) was the most prolific country, and Fudan University (n = 90) was the most notable institution. Furthermore, we observed that Lau Wan Yee participated in most studies (n = 26), and Frontiers in Oncology (IF2020:6.24) published the highest number of documents (n = 49) on this subject, with 138 publications. The paper “Bray F, 2018, CA-CANCER J CLIN, V68, P394” has the highest number of co-cited references, with 119 citations. In addition, the top three keywords were “survival”, “recurrence”, and “microvascular invasion”. Moreover, the research hot spots and frontiers of HCC-MVI for the last 3 years included imaging characteristics and transarterial chemoembolization (TACE) therapy studies.

Conclusions

This study comprehensively summarized the most significant HCC-MVI documents from past literature and highlighted key contributions made to the advancement of this subject and the advancement of this field over the past decade. The trend of MVI research will gradually shift from risk factors and prognosis studies to imaging characteristics and TACE therapy studies.