bluuebunny/crossref_metadata_2025 huggingface dataset:
Predicting immunotherapy outcomes in patients with MSI tumors using NLR and CT global tumor volume
Authors: Belkouchi Younes , Nebot-Bral Laetitia , Lawrance Littisha , Kind Michele , David Clémence , Ammari Samy , Cournède Paul-Henry , Talbot Hugues , Vuagnat Perrine , Smolenschi Cristina , Kannouche Patricia L. , Chaput Nathalie , Lassau Nathalie , Hollebecque Antoine
Published: October 2022

Background

Anti-PD-(L)1 treatment is indicated for patients with mismatch repair-deficient (MMRD) tumors, regardless of tumor origin. However, the response rate is highly heterogeneous across MMRD tumors. The objective of the study is to find a score that predicts anti-PD-(L)1 response in patients with MMRD tumors.

Methods

Sixty-one patients with various origin of MMRD tumors and treated with anti-PD-(L)1 were retrospectively included in this study. An expert radiologist annotated all tumors present at the baseline and first evaluation CT-scans for all the patients by circumscribing them on their largest axial axis (single slice), allowing us to compute an approximation of their tumor volume. In total, 2120 lesions were annotated, which led to the computation of the total tumor volume for each patient. The RECIST sum of target lesions’ diameters and neutrophile-to-lymphocyte (NLR) were also reported at both examinations. These parameters were determined at baseline and first evaluation and the variation between the first evaluation and baseline was calculated, to determine a comprehensive score for overall survival (OS) and progression-free survival (PFS).

Results

Total tumor volume at baseline was found to be significantly correlated to the OS (p-value: 0.005) and to the PFS (p-value:<0.001). The variation of the RECIST sum of target lesions’ diameters, total tumor volume and NLR were found to be significantly associated to the OS (p-values:<0.001, 0.006,<0.001 respectively) and to the PFS (<0.001,<0.001, 0.007 respectively). The concordance score combining total tumor volume and NLR variation was better at stratifying patients compared to the tumor volume or NLR taken individually according to the OS (pairwise log-rank test p-values: 0.033,<0.001, 0.002) and PFS (pairwise log-rank test p-values: 0.041,<0.001, 0.003).

Conclusion

Total tumor volume appears to be a prognostic biomarker of anti-PD-(L)1 response to immunotherapy in metastatic patients with MMRD tumors. Combining tumor volume and NLR with a simple concordance score stratifies patients well according to their survival and offers a good predictive measure of response to immunotherapy.
Efficacy of PD-1/PD-L1 inhibitors in patients with advanced gastroesophageal cancer: An updated meta-analysis based on randomized controlled trials
Authors: Gu Lihu , Huang Tongmin , Qiu Shinan , Hong Jiaze , Fu Rongrong , Ni Chaoxiong , Dai Senjie , Chen Ping , He Ning
Published: October 2022

Background: This study aimed to investigate the clinical efficacy of programmed death-1 receptor and ligand-1 (PD-1/PD-L1) inhibitors in gastroesophageal cancer patients and the relationship between their clinicopathological features and curative treatment effects.

Methods: A systematic search was conducted for articles published before April 2022 from online databases (PubMed, EMBASE, Web of Science and the Cochrane Library). The main outcome was overall survival (OS).

Results: This meta-analysis comprised 16 studies involving 9,304 participants. The results indicated that compared with chemotherapy, patients treated with PD-1/PD-L1 inhibitors had significantly improved OS (HR = 0.80; p < 0.001) but no significant improvement in progression-free survival (PFS) (p = 0.185). Subgroup analyses demonstrated that PD-1/PD-L1 inhibitors combined with chemotherapy, esophageal squamous cell carcinoma, male, Asian patients and combined positive score (CPS) ≥1 were significantly associated with better survival outcomes. Further, subgroup analysis of gender revealed that the OS of all subgroups containing male patients was significantly improved compared with chemotherapy, unlike that of female patients. In addition, the line of therapy, Lauren classification, age and eastern cooperative oncology group (ECOG) performance status were not associated with PD-1/PD-L1 inhibitors efficacy.

Conclusion: The results indicated that PD-1/PD-L1 inhibitors could prolong the OS of advanced gastroesophageal cancer patients. Clinicopathological features such as therapeutic schedules, tumor types, histological type, gender, geographical region and PD-L1 expression status (CPS) seemed to be associated with survival outcomes.
Biological and therapeutic role of LSD1 in Alzheimer’s diseases
Authors: Li Yu , Zhao Yuanyuan , Li Xiaona , Zhai Liuqun , Zheng Hua , Yan Ying , Fu Qiang , Ma Jinlian , Fu Haier , Zhang Zhenqiang , Li Zhonghua
Published: October 2022

Alzheimer’s disease (AD) is a common chronic neurodegenerative disease characterized by cognitive learning and memory impairments, however, current treatments only provide symptomatic relief. Lysine-specific demethylase 1 (LSD1), regulating the homeostasis of histone methylation, plays an important role in the pathogenesis of many neurodegenerative disorders. LSD1 functions in regulating gene expression via transcriptional repression or activation, and is involved in initiation and progression of AD. Pharmacological inhibition of LSD1 has shown promising therapeutic benefits for AD treatment. In this review, we attempt to elaborate on the role of LSD1 in some aspects of AD including neuroinflammation, autophagy, neurotransmitters, ferroptosis, tau protein, as well as LSD1 inhibitors under clinical assessments for AD treatment.
Administration of USP7 inhibitor P22077 inhibited cardiac hypertrophy and remodeling in Ang II-induced hypertensive mice
Authors: Gu Yu-Hui , Ren Kai-Wen , Wang Yu , Wang Shi-Hao , Yu Xiao-Hong , Xu Li-Wen , Li Hui-Hua , Bi Hai-Lian
Published: October 2022

Hypertension is one of the common causes of pathological cardiac hypertrophy and a major risk for morbidity and mortality of cardiovascular diseases worldwide. Ubiquitin-Specific Protease 7 (USP7), the first identified deubiquitinating enzymes, participated in a variety of biological processes, such as cell proliferation, DNA damage response, tumourigenesis, and apoptosis. However, its role and mechanism in cardiac remodeling remain unclear. Here, our data indicated that USP7 expression was increased during Ang II-induced cardiac hypertrophy and remodeling in mice and humans with heart failure, while the administration of its inhibitor p22077 attenuated cardiac hypertrophy, cardiac fibrosis, inflammation, and oxidase stress. Mechanistically, the administration of p22077 inhibited the multiple signaling pathways, including AKT/ERK, TGF-β/SMAD2/Collagen I/Collagen III, NF-κB/NLRP3, and NAPDH oxidases (NOX2 and NOX4). Taken together, these findings demonstrate that USP7 may be a new therapeutic target for hypertrophic remodeling and HF.
Berberine prevents lethal EV71 neurological infection in newborn mice
Authors: Cui Guangyi , Wang Han , Yang Chongting , Zhou Xiaoxiao , Wang Junyi , Wang Tong , Ma Tonghui
Published: October 2022

Enterovirus 71 (EV71) is the major pathogen causing fatal neurological complications of hand, foot, and mouth disease (HFMD) in young children. Currently no effective antiviral therapy is available. In the present study, we found that natural compound Berberine (BBR) displayed potent inhibitory effects on EV71 replication in various neural cells (IC50 of 2.79–4.03 μM). In a newborn mouse model of lethal EV71 infection, Berberine at 2–5 mg/kg markedly reduced mortality and clinical scores. Consistently, the replication of EV71 and pathological changes were attenuated in various infected organs including brain and lung with BBR treatment. Interestingly, EV71 infection in the brain mainly localized in the peripheral zone of brainstem and largely in astrocytes. Primary culture of astrocytes from newborn mouse brain confirmed the efficient EV71 replication that was mostly inhibited by BBR treatment at 5 μM. Further investigations revealed remarkably elevated cellular reactive oxygen species (ROS) levels that coincided with EV71 replication in primary cultured astrocytes and various cell lines. BBR largely abolished the virus-elevated ROS production and greatly diminished EV71 replication by up-regulating NFE2 like bZIP transcription factor 2 (Nrf2) via the kelch like ECH associated protein 1 (Keap)-Nrf2 axis. The nuclear localization of Nrf2 and expression of downstream antioxidant enzymes heme oxygenase 1 (HO-1) and NAD(P)H quinone dehydrogenase 1 (NQO1) were increased significantly by BBR treatment. Collectively, our findings revealed that BBR prevents lethal EV71 neurological infection via inhibiting virus replication through regulating Keap-Nrf2 axis and ROS generation in astrocytes of brainstem, thus providing a potential antiviral treatment for severe EV71 infection associated with neurological complications.
Circulating galectin-3 promotes tumor-endothelium-adhesion by upregulating ICAM-1 in endothelium-derived extracellular vesicles
Authors: Wang Lei , Du Dan-Dan , Zheng Zong-Xue , Shang Peng-Fei , Yang Xiao-Xia , Sun Chao , Wang Xiao-Yan , Tang Ya-Jie , Guo Xiu-Li
Published: October 2022

The adhesion of tumor cells to vascular endothelial cells is an important process of tumor metastasis. Studies have shown that tumor could educate vascular endothelial cells to promote tumor metastasis through many ways. However, the effect of tumor cells on the functions of vascular endothelial cells-derived extracellular vesicles (H-EVs) and the mechanisms underlying their effects in tumor-endothelium adhesion in metastasis remain mysterious. In this study, we found that H-EVs promoted the adhesion of triple negative breast cancer cell to endothelial cells and cirGal-3 enhanced the adhesion-promoting effects of H-EVs. The underlying mechanism was related to the upregulation of glycolysis in endothelial cells induced by cirGal-3 which led to the increase of the ICAM-1 expression and its transmission to MDA-MB-231 cells by H-EVs. Targeting of cirGal-3 or glycolysis of vascular endothelium in breast cancer therefore represents a promising therapeutic strategy to reduce metastasis.
CD82 attenuates TGF-β1-mediated epithelial-mesenchymal transition by blocking smad-dependent signaling in ARPE-19 cells
Authors: Lee Hyesook , Han Jung-Hwa , Kang Yun Jeong , Hwangbo Hyun , Yoon Aeseon , Kim Hyung-Sik , Lee Dongjun , Lee Soo Yong , Choi Byung Hyun , Kim Jae-Joon , Kim Seo Rin , Choi Yung Hyun , Hur Jin
Published: October 2022

In retinal pigment epithelial (RPE) cells, transforming growth factor-beta (TGF-β) plays a critical role in epithelial-mesenchymal transition (EMT), which contributes to various fibrotic retinal disorders. In the present study, we investigated the effect of recombinant human cluster of differentiation 82 (rhCD82), a tumor metastasis suppressor, on TGF-β-induced EMT in the human RPE cell line APRE-19. The results show that TGF-β1 significantly enhanced cell migration, invasion and the expression of EMT-mediate factors in ARPE-19 cells. However, rhCD82 markedly inhibited cell mobility and the expression of epithelial marker, zonula occludens-1, as well as increased the expression of mesenchymal markers, such as vimentin and α-smooth muscle actin in TGF-β1-treated APRE-19 cells. In addition, TGF-β1 upregulated the phosphorylation of Smad, extracellular signal regulated kinase (ERK) and glycogen synthase kinase-3β (GSK-3β), but only phosphorylation of Smad was suppressed by rhCD82. Noteworthy, rhCD82 greatly suppressed the expression of TGF-β receptor I (TGFRI), TGFRII and integrins in TGF-β1-treated APRE-19 cells. In particular, the result of molecular docking analysis and structural modeling show that rhCD82 partially interacts with the TGF-β1 binding sites of TGFRI, TGFRII, integrin β1 and integrin αv. Taken together, this finding suggested that rhCD82 suppressed TGF-β1-induced EMT of RPE by blocking of Smad-dependent pathway, which is caused by rhCD82 interaction with TGFRs and integrins, suggesting new insight into CD82 as a potential therapeutic strategy in fibrotic retinal disorders.
Simplicial temporal networks from Wi-Fi data in a university campus: The effects of restrictions on epidemic spreading
Authors: Guizzo Andrea , Vezzani Alessandro , Barontini Andrea , Russo Fabrizio , Valenti Cristiano , Mamei Marco , Burioni Raffaella
Published: October 2022

Wireless networks are commonly used in public spaces, universities, and public institutions and provide accurate and easily accessible information to monitor the mobility and behavior of users. Following the application of containment measures during the recent pandemic, we analyzed extensive data from the Wi-Fi network in a university campus in Italy during three periods, corresponding to partial lockdown, partial opening, and almost complete opening. We measured the probability distributions of groups and link activations at Wi-Fi access points, investigating how different areas are used in the presence of restrictions. We ranked the hotspots and the area they cover according to their crowding and to the probability of link formation, which is the relevant variable in determining potential outbreaks. We considered a recently proposed epidemic model on simplicial temporal networks, and we used the measured distributions to infer the change in the reproduction number in the three phases. Our data show that additional measures are necessary to limit the spread of epidemic in the total opening phase due to the dramatic increase in the number of contacts.
Integrated application of bacterial carbonate precipitation and silicon nanoparticles enhances productivity, physiological attributes, and antioxidant defenses of wheat (Triticum aestivum L.) under semi-arid conditions
Authors: Desoky El-Sayed M. , Rady Mostafa M. , Nader Maha M. , Mostafa Nadeen G. , Elrys Ahmed S. , Mathai Archana , AbuQamar Synan F. , El-Tarabily Khaled A. , El-Saadony Mohamed T.
Published: October 2022

The use of calcium carbonate-precipitating bacteria (CCPB) has become a well-established ground-improvement technique. However, the effect of the interaction of CCPB with nanoparticles (NPs) on plant performance is still meager. In this study, we aimed at evaluating the role of CCPB and/or silicon NPs (Si-NPs) on the growth, physio-biochemical traits, and antioxidative defense of wheat (Triticum aestivumL.) under semi-arid environmental conditions. A 2-year pot experiment was carried out to determine the improvement of the sandy soil inoculated with CCPB and the foliar application of Si-NPs on wheat plants. We tested the following treatments: spraying plants with 1.0 or 1.5 mM Si-NPs (control = 0 mM Si-NPs), soil inoculated withBacillus lichenforms(MA16),Bacillus megaterium(MA27), orBacillus subtilis(MA34), and the interaction of individualBacillusspecies with Si-NPs. Our results showed that soil inoculation with any of the three isolated CCPB and/or foliar application of Si-NPs at the rates of 1.0 or 1.5 mM significantly improved (p≤ 0.05) the physiological and biochemical attributes as well as the enzymatic antioxidant activities of wheat plants. Therefore, the combined treatments of CCPB + Si-NPs were more effective in enhancing physio-biochemical characteristics and enzymatic antioxidant activities than the individual treatments of CCPB or Si-NPs, thus achieving the best performance in the treatment of MA34 + 1.5 mM Si-NPs. Our results demonstrated that the co-application of CCPB and Si-NPs, particularly MA34 + 1.5 mM Si-NPs, considerably activated the antioxidant defense system to mitigate the adverse effects of oxidative stress, thus increasing tolerance and enhancing the production of wheat plants in sandy soils under semi-arid environmental conditions.
Pest-YOLO: A model for large-scale multi-class dense and tiny pest detection and counting
Authors: Wen Changji , Chen Hongrui , Ma Zhenyu , Zhang Tian , Yang Ce , Su Hengqiang , Chen Hongbing
Published: October 2022

Frequent outbreaks of agricultural pests can reduce crop production severely and restrict agricultural production. Therefore, automatic monitoring and precise recognition of crop pests have a high practical value in the process of agricultural planting. In recent years, pest recognition and detection have been rapidly improved with the development of deep learning-based methods. Although certain progress has been made in the research on pest detection and identification technology based on deep learning, there are still many problems in the production application in a field environment. This work presents a pest detector for multi-category dense and tiny pests named the Pest-YOLO. First, the idea of focal loss is introduced into the loss function using weight distribution to improve the attention of hard samples. In this way, the problems of hard samples arose from the uneven distribution of pest populations in a dataset and low discrimination features of small pests are relieved. Next, a non-Intersection over Union bounding box selection and suppression algorithm, the confluence strategy, is used. The confluence strategy can eliminate the errors and omissions of pest detection caused by occlusion, adhesion and unlabeling among tiny dense pest individuals to the greatest extent. The proposed Pest-YOLO model is verified on a large-scale pest image dataset, the Pest24, which includes more than 20k images with over 190k pests labeled by agricultural experts and categorized into 24 classes. Experimental results show that the Pest-YOLO can obtain 69.59% for mAP and 77.71% for mRecall on the 24-class pest dataset, which is 5.32% and 28.12% higher than the benchmark model YOLOv4. Meanwhile, our proposed model is superior to other several state-of-the-art methods, including the SSD, RetinaNet, Faster RCNN, YOLOv3, YOLOv4, YOLOv5s, YOLOv5m, YOLOX, DETR, TOOD, YOLOv3-W, and AF-RCNN detectors. The code of the proposed algorithm is available at: https://github.com/chr-secrect/Pest-YOLO.
Did the cyberspace foster the entrepreneurship of women with children in rural China?
Authors: Shao KaiChao , Ma Ruixue , Zhao Lulu , Wang Kai , Kamber Joseph
Published: October 2022

Female-entrepreneurship plays a significantly important role in rural areas of China today. In fact, it is a driving force behind inclusive economic development of the country as a whole. However, notably very little literature out there has focused on the impact of how widespread usage of information technology tools affects the mothers entrepreneurship in the outskirt regions. Here, in this paper, the authors attempt to explore the finer details of such an impact by utilizing the data from the 2017 China Integrated Social Survey; along with the IV-Probit model to explore the transmission mechanism. Interestingly enough, it was discovered that Internet applications and tools do indeed increase entrepreneurship among women with children by a roughly 7.88%. In addition, this paper finds that the utilization of such “InfoTech” promote a continuous progress in entrepreneurship among those women with children who endeavor to start a self-managed enterprise in the less developed areas. Lastly, when looking the analysis of the transmission mechanism, this paper found that the role of Internet-usage in promoting rural mothers entrepreneurship was mainly through three factors – the gender equality effect, the information learning effect, and the financing effect. This accumulated data will be thoroughly presented here in the ensuing sections.
Making the difficult career transition: Writing the next chapter during the great resignation or in the future
Authors: Coppola Paul J. , Young Aprille F.
Published: October 2022

During the midst of the Great Resignation, over 4.5 million people have changed jobs. While a job change does not register as one of the top three drivers of stress, career transition-related stress does present itself as one of the top 25 causes. This stress can be reduced through social support models, career transition planning, and personal brand strategy frameworks. These adaptive change models become part of a continuous learning and growth process. This literature review aims to contribute to the industry and define career transition through a more holistic personal brand strategy utilizing a wide range of disciplines considering the challenges and opportunities presented during the Great Resignation.
Peer effect of enterprise innovation: Empirical evidence from China
Authors: Liu Li , Yang Jiguo , Zheng Minna , Jin Linlin
Published: October 2022

Innovation investment is crucial to enterprise development and economic growth. As peer enterprises face similar market environment and development prospects, they pay attention to the innovation activities of peer enterprises in the industry because of economic rationality or the idea of seeking advantages and avoiding disadvantages. This paper aims to investigate the interaction and channel of enterprise innovation behavior of peer effect based on the data of Chinese share-listed enterprises from 2010 to 2021. The results show that peer effect exists in the innovation behavior of enterprises. We also provide evidence that managerial ability is the mechanism of the peer effect of enterprise innovation. In addition, we find that small-scale enterprises are more likely to be affected by the innovation behavior of peer enterprises compared with large enterprises. More importantly, we reveal that economic policy uncertainty significantly negatively regulates the peer effect of enterprise innovation.

JEL classification

G30, G31, O31
The role of individual variables as antecedents of entrepreneurship processes: Emotional intelligence and self-efficacy
Authors: López-Núñez María Inmaculada , Rubio-Valdehita Susana , Díaz-Ramiro Eva M.
Published: October 2022

Currently, entrepreneurship is a priority for economic, social, and technological growth. Therefore, the interest in understanding entrepreneurship processes has increased significantly. Individual variables play a fundamental role, and academic research has pointed out the influence of emotional intelligence in entrepreneurial processes; however, its relationship with other interpersonal processes and individual variables, such as personality and self-efficacy, has not been extensively studied. The aim of this research was to analyze the relationship among emotional intelligence, self-efficacy, and entrepreneurial intention, controlling for the effects of personality, gender, and age. Multiple hierarchical regression analyses were applied through a questionnaire survey of 1,593 college students to test the relationship between the constructs in the model. The results show that the personality traits are associated with entrepreneurial self-efficacy, emotional intelligence positively influences entrepreneurial intention, and self-efficacy mediates the relationship between emotional intelligence and entrepreneurial intention. Practical implications for training programs are examined, and future lines of research were discussed.
The impact of a terrorist attack: Survivors’ health, functioning and need for support following the 2019 Utrecht tram shooting 6 and 18 months post-attack
Authors: Bosmans Mark W. G. , Plevier Carolien , Schutz Francoise , Stene Lise E. , Yzermans C. Joris , Dückers Michel L. A.
Published: October 2022

Background

Extremely violent events such as terrorist attacks and mass shootings form a severe risk for the health and wellbeing of affected individuals. In this study based on a public health monitor, we focus on the health impact (including PTSD symptoms, physical problems and day-to-day functioning) of the Utrecht tram shooting, which took place in the morning of March 18th 2019. A lone gunman opened fire on passengers within a moving tram. Four people died, and six people were injured in this attack. The attack resulted in nationwide commotion and drew much media attention. Aim of this study was to increase insight into the health effects for the survivors (those directly impacted by a terrorist attack and the bereaved), and whether they received the needed care and support.

Methods

Semi-structured interviews with accompanying questionnaires were conducted at six and 18 months post-attack. Overall, 21 survivors (victims/witnesses and loved ones of deceased victims) participated in the first series of interviews, 15 in the second series. Qualitative data were analyzed using reflexive thematic analysis, quantitative data was only described because of the low sample size.

Results

At both six and 18 months after the attack many survivors had been able to resume daily life, and most rated their overall health as (very) good or excellent. At the same time, a substantial portion suffered from health problems such as posttraumatic stress symptoms and other complaints, and needed professional care. Furthermore, those in need did not always find their own way to appropriate care through the existing health system: half of the survivors still needed support in finding the right care 18 months later.

Conclusion

Although the design and implementation of this public health monitor were accompanied by multiple challenges, it was possible to track a portion of the survivors and gain insight in the considerable health burden of the attack. Also, it is clear in this study that the health impact of terrorism affects survivors in the long run and requires attention from health authorities and professionals, as survivors were not able to find the right care by themselves.
Research on factors affecting serial entrepreneurial intention: An interpretive structure model
Authors: Bai Xiuwei , Cheng Dejun , Chen Yuting
Published: October 2022

Serial entrepreneurship is a very common phenomenon in the world. Research on serial entrepreneurs is the core of understanding entrepreneurship and entrepreneurs, such as, why entrepreneurs insist on starting businesses many times? What affects the sustainability of entrepreneurship? Based on the interpretive structure model of systems engineering, this study constructs a hierarchical model of the factors affecting serial entrepreneurial intention, which proposed the basic conditions, key factors, and paths affecting serial entrepreneurial intention. Based on this, the hierarchical model of factors affecting serial entrepreneurial intention is also tested through a typical serial entrepreneurial case. The results show that: (1) there are 16 factors affecting serial entrepreneurial intention, and each factor plays a role at a specific level; (2) entrepreneurial expectations and identification and evaluation of opportunities are the key factors affecting serial entrepreneurial intention. We can improve the ability of the identification and evaluation of opportunities through entrepreneurial failure learning, and form reasonable entrepreneurial expectations; (3) entrepreneurial cognitive schema and behavioral addiction tendency directly affect entrepreneurs’ identification and evaluation of opportunities; (4) demographic factors, financial conditions, environmental conditions, and entrepreneurial experience are the basic conditions that affect serial entrepreneurial intention indirectly through emotional perception and motivation factors.
The promising fNIRS: Uncovering the function of prefrontal working memory networks based on multi-cognitive tasks
Authors: Ren Yufei , Cui Gang , Zhang Xiaoqian , Feng Kun , Yu Chenchao , Liu Pozi
Published: October 2022

The diversity of cognitive task paradigms using functional near-infrared spectroscopy (fNIRS) and the lack of theoretical explanations for these functional imaging atlases have greatly hindered the application of fNIRS in psychiatry. The fNIRS brain imaging based on multiple cognitive tasks could generally reflect the working patterns and neurovascular coupling changes in the prefrontal working memory network. By alternating the stimulation patterns of resting and task states, six typical symptom-related functional brain imaging waveforms related to psychiatric disorders are identified and three joint networks of the prefrontal working memory, namely, the attentional working memory primary coordination network, the perceptual content working memory secondary network, and the emotional-behavioral working memory executive network, are initially represented. This is the first attempt to characterize the cognitive, emotional, and behavioral regulation of the prefrontal working memory network using fNIRS, which may promote the application of fNIRS in clinical settings.
Psychometric evaluation of the depression anxiety stress scale 8-items (DASS-8)/DASS-12/DASS-21 among family caregivers of patients with dementia
Authors: Ali Amira Mohammed , Alameri Rana Ali , Hendawy Amin Omar , Al-Amer Rasmieh , Shahrour Ghada , Ali Esraa M. , Alkhamees Abdulmajeed A. , Ibrahim Nashwa , Hassan Bothaina Hussein
Published: October 2022

Patients with dementia express a set of problematic and deteriorating symptoms, along with self-care dependency. Over time, the mental health of family caregivers of persons with dementia may be affected, putting them at a high risk for psychopathology, which may be associated with endangered wellbeing of people with dementia. This cross-sectional instrumental design study examined the psychometric properties of the Depression Anxiety Stress Scale 8-items (DASS-8), DASS-12, and DASS-21 in a convenient sample of 571 caregivers from northern Italy and southern Switzerland (mean age = 53 years, SD = 12, range = 24–89 years). A bifactor structure of the three measures had the best fit; some items of the DASS-12/DASS-21 failed to load on their domain-specific factors. The three-factor structure was invariant across various groups (e.g., gender and education), expressed adequate reliability and convergent validity, and had strong positive correlation with the three-item UCLA Loneliness Scale (UCLALS3). Distress scores did not differ among carers of different types of dementia (Alzheimer's disease vs. other types, e.g., vascular dementia). However, distress scores were significantly high among female individuals, adult children caregivers, those caring for dependent patients, and those who received help with care. For 54.9 and 38.8% of the latter, care was provided by relatives and health professionals, respectively. Since the DASS-8 expresses adequate psychometrics comparable with the DASS-21, it may be used as a brief measure of distress in this population.
Predicting the risk of HIV infection among internal migrant MSM in China: An optimal model based on three variable selection methods
Authors: Liu Shangbin , Xia Danni , Wang Yuxuan , Xu Huifang , Xu Lulu , Yuan Dong , Liang Ajuan , Chang Ruijie , Wang Rongxi , Liu Yujie , Chen Hui , Hu Fan , Cai Yong , Wang Ying
Published: October 2022

Introduction

Internal migrant Men who have sex with men (IMMSM), which has the dual identity of MSM and floating population, should be more concerned among the vulnerable groups for HIV in society. Establishing appropriate prediction models to assess the risk of HIV infection among IMMSM is of great significance to against HIV infection and transmission.

Methods

HIV and syphilis infection were detected using rapid test kits, and other 30 variables were collected among IMMSM through questionnaire. Taking HIV infection status as the dependent variable, three methods were used to screen predictors and three prediction models were developed respectively. The Hosmer-Lemeshow test was performed to verify the fit of the models, and the net classification improvement and integrated discrimination improvement were used to compare these models to determine the optimal model. Based on the optimal model, a prediction nomogram was developed as an instrument to assess the risk of HIV infection among IMMSM. To quantify the predictive ability of the nomogram, the C-index measurement was performed, and internal validation was performed using bootstrap method. The receiver operating characteristic (ROC) curve, calibration plot and dynamic component analysis (DCA) were respectively performed to assess the efficacy, accuracy and clinical utility of the prediction nomogram.

Results

In this study, 12.52% IMMSMs were tested HIV-positive and 8.0% IMMSMs were tested syphilis-positive. Model A, model B, and model C fitted well, and model B was the optimal model. A nomogram was developed based on the model B. The C-index of the nomogram was 0.757 (95% CI: 0.701–0.812), and the C-index of internal verification was 0.705.

Conclusions

The model established by stepwise selection methods incorporating 11 risk factors (age, education, marriage, monthly income, verbal violence, syphilis, score of CUSS, score of RSES, score of ULS, score of ES and score of DS) was the optimal model that achieved the best predictive power. The risk nomogram based on the optimal model had relatively good efficacy, accuracy and clinical utility in identifying internal migrant MSM at high-risk for HIV infection, which is helpful for developing targeted intervention for them.
Determinants of virological failure among patients on first line highly active antiretroviral therapy (HAART) in Southwest Ethiopia: A case-control study
Authors: Bogale Biruk , Asefa Adane , Destaw Alemnew , Midaksa Gachana , Asaye Zufan , Alemu Gebremichael Mathewos , Wolde Asrat Arja , Yimer Ejig , Yosef Tewodros
Published: October 2022

Background

Virological failure remains a public health concern among patients with human immunodeficiency virus (HIV) after treatment initiation. Ethiopia is one of the countries that aims to achieve the global target of 90-90-90 that aims to achieve 90% virological suppression, but there is a paucity of evidence on the determinants of virological failure. Therefore, the study is intended to assess determinants of virological treatment failure among patients on first-line highly active antiretroviral therapy (HAART) at Mizan Tepi University Teaching Hospital (MTUTH), Southwest Ethiopia.

Method

A hospital-based unmatched case-control study was conducted from 11 November to 23 December 2020, among 146 cases and 146 controls. All cases and controls were selected randomly using computer-generated random numbers based on their medical record numbers. During the document review, data were collected using checklists, entered into Epi-data version 4.0.2, and analyzed by SPSS version 25. A multivariable logistic regression analysis was done to identify the independent determinants of virological treatment failure.

Results

In this study, being male (adjusted odds ratio (AOR) = 1.89, 95% CI: 1.04, 3.47), substance use (AOR = 2.67, 95% CI: 1.40, 4.95), baseline hemoglobin (Hgb) < 12 mg/dl (AOR = 3.22, 95% CI: 1.82, 5.99), poor drug adherence (AOR = 3.84, 95% CI: 1.77, 5.95), restart ART medication (AOR = 2.45, 95% CI: 1.69, 7.35), and opportunistic infection (OI) while on HAART (AOR = 4.73, 95% CI: 1.76, 12.11) were determinants of virological treatment failure.

Conclusion

The study revealed that the sex of the patient, history of substance use, baseline Hgb < 12 mg/dl, poor drug adherence, restart after an interruption, and having OI through the follow-up period were determinants of virological failure. Therefore, program implementation should consider gender disparity while men are more prone to virological failure. It is also imperative to implement targeted interventions to improve drug adherence and interruption problems in follow-up care. Moreover, patients with opportunistic infections and restart HAART need special care and attention.
Congruence and discrepancy in Asian American women's perception and stress appraisal of gendered racial microaggressions: Relationships with depressive symptoms and internalized racism
Authors: Keum Brian TaeHyuk , Wong Michele J.
Published: October 2022

Prior research demonstrates significant links between discrimination and mental health by assessing either encounters with or stress appraisal of discrimination. However, research has yet to examine the dynamic interplay between frequency and stress appraisal (e.g., high frequency-low stress appraisal) and their linkage to depressive symptoms. Using a sample of 309 Asian American women (Mage = 22.81, SD = 0.26), we used a polynomial regression and response surface analysis to model the congruence and discrepancy between frequency and stress appraisal of gendered racial microaggressions experienced by Asian American women and how they are related to depressive symptoms and internalized racism. The dynamics between frequency and stress in relation to depressive symptoms were further probed at low, mean, and high levels of internalized racism. Greater congruence between frequency and stress was significantly associated with depressive symptoms (medium to large effect) and internalized racism (small effect). A discrepancy between higher frequency and lower stress was significantly associated with greater internalized racism. Further, when looking across levels of internalized racism, greater congruence between frequency and stress was significantly associated with greater depressive symptoms at low and mean levels of internalized racism but not at high levels. Gendered racial microaggressions are associated with adverse mental health outcomes among Asian American women, contributing to greater depressive symptoms and internalized racism. Further consideration should be given toward how internalized racism shapes differences in the perceptions and stress appraisal of gendered racial microaggressions, and subsequent mental health outcomes among Asian American women.
When workaholism is negatively associated with burnout: A moderated mediation
Authors: Makhdoom Irsa Fatima , Malik Najma Iqbal , Atta Mohsin , Malik Nudra , Qureshi Madeeha Gohar , Shahid Muhammad , Tang Kun
Published: October 2022

Aim

Previous theory and research postulate that workaholism is one of the important factors that contribute to burnout. The present study aimed to analyze the role of psychological capital as a mediator between the two. Moreover, the study examined the moderating role in the stated mediated relationship.

Methods

The researchers approached a sample of university teachers (N= 1,008) including both male (n= 531) and female (n= 477) university teachers by using a multi-stage random sampling technique. For this purpose, DUWAS-10 Oldenburg Burnout Inventory, Challenging Job Demands Scale, and Anila PsyCap Scale were applied to measure workaholism, burnout, challenging job demands, and PsyCap, respectively. The data obtained from the sample was subjected to analysis by using Model 14 of Process Macro by Hayes.

Results

The results confirmed the mediating role of PsyCap and moderating role of time pressure and cognitive demands in the relationship of the two variables. The results concluded that workaholism is not directly related to burnout rather the negative relationship existed through psychological capital, and the mediated relationship was stronger for the university employees who were to face a higher level of challenging job demands including cognitive demands and time pressure.

Conclusion

Burnout is an occupational health problem that causes devastating effects on both the employees as well as to the organizational economy. Improving personal resources might help the negative relationship between workaholism and burnout in higher education institutions in the country.
Psychological wellbeing and the association with burnout in a cohort of healthcare workers during the COVID-19 pandemic
Authors: Bannon Jacqueline , Evans Charlesnika T. , Freedman Melanie , Lee Cerina , Vu Thanh Huyen , Wallia Amisha , Wilkins John T. , Moskowitz Judith T. , Hirschhorn Lisa R.
Published: October 2022

Burnout, depression, and anxiety are prevalent among healthcare workers (HCWs) during the COVID-19 pandemic and have been previously shown to contribute to poor health outcomes and reduced quality of care. Positive psychological constructs such as positive affect and meaning and purpose are related to resilience in the face of significant stress. No studies have examined these associations among a cohort of HCWs during this pandemic. The purpose of this study was to examine the association of depression, anxiety, positive affect, and meaning and purpose with burnout among HCWs during the COVID-19 pandemic. We utilized data from a cross-sectional survey conducted between September 29-December 8, 2021, among a cohort of 2,411 HCWs from a large, tertiary academic health care system in the Chicago area. We employed the Patient-Reported Outcomes Measurement Information System (PROMIS) measures for depression, anxiety, positive affect, and meaning and purpose and burnout was measured by the Oldenburg Burnout Inventory (OLBI). The majority (80.88%) of HCWs in this study identified as White, Non-Hispanic race/ethnicity, female sex (82.37%), and roughly one third were between ages 30–39 years old (30.98%). Registered nurses (26.96%) accounted for the largest single occupation group. The mean burnout score was 36.87 (SD = 7.65), with 53.38% of participants classified as having burnout, and registered nurses demonstrating the highest proportions of burnout (63.54%). Higher depression (coef = 0.15, SE = 0.03, p < 0.001) and anxiety (coef = 0.25, SE = 0.02, p < 0.001) scores were associated with higher burnout in multivariable linear regression models. Increased positive affect (coef= −0.19, SE= 0.02, p < 0.001) and meaning and purpose (coef= −0.12, SE= 0.01, p < 0.001) scores were significantly associated with reduced burnout. Positive affect and meaning and purpose were inversely associated with burnout among a cohort of HCWs during the COVID-19 pandemic. Previous studies of positive affect and meaning and purpose suggest the potential buffering effect that these indices may have on burnout. Future research is needed to examine the effect of positive affect and meaning and purpose on mitigating the negative impacts of burnout, depression, and anxiety among HCWs as they cope with the stress of the COVID-19 pandemic and beyond.
Experimental validation of the Kibble-Zurek mechanism on a digital quantum computer
Authors: Higuera-Quintero Santiago , Rodríguez Ferney J. , Quiroga Luis , Gómez-Ruiz Fernando J.
Published: October 2022

The Kibble-Zurek mechanism (KZM) captures the essential physics of nonequilibrium quantum phase transitions with symmetry breaking. KZM predicts a universal scaling power law for the defect density which is fully determined by the system’s critical exponents at equilibrium and the quenching rate. We experimentally tested the KZM for the simplest quantum case, a single qubit under the Landau-Zener evolution, on an open access IBM quantum computer (IBM-Q). We find that for this simple one-qubit model, experimental data validates the central KZM assumption of the adiabatic-impulse approximation for a well isolated qubit. Furthermore, we report on extensive IBM-Q experiments on individual qubits embedded in different circuit environments and topologies, separately elucidating the role of crosstalk between qubits and the increasing decoherence effects associated with the quantum circuit depth on the KZM predictions. Our results strongly suggest that increasing circuit depth acts as a decoherence source, producing a rapid deviation of experimental data from theoretical unitary predictions.
Prospects for detection of a galactic diffuse neutrino flux
Authors: De La Torre Luque P. , Gaggero D. , Grasso D. , Marinelli A.
Published: October 2022

A Galactic cosmic-ray transport model featuring non-homogeneous transport has been developed over the latest years. This setup is aimed at reproducing γ-ray observations in different regions of the Galaxy (with particular focus on the progressive hardening of the hadronic spectrum in the inner Galaxy) and was shown to be compatible with the very-high-energy γ-ray diffuse emission recently detected up to PeV energies. In this work, we extend the results previously presented to test the reliability of that model throughout the whole sky. To this aim, we compare our predictions with detailed longitude and latitude profiles of the diffuse γ-ray emission measured by Fermi-LAT for different energies and compute the expected Galactic ν diffuse emission, comparing it with current limits from the ANTARES collaboration. We emphasize that the possible detection of a Galactic ν component will allow us to break the degeneracy between our model and other scenarios featuring prominent contributions from unresolved sources and TeV halos.
A novel nomogram based on the prognostic nutritional index for predicting postoperative outcomes in patients with stage I–III gastric cancer undergoing robotic radical gastrectomy
Authors: Shen Danli , Zhou Guowei , Zhao Jian , Wang Gang , Jiang Zhiwei , Liu Jiang , Wang Haifeng , Deng Zhengming , Ma Chaoqun , Li Jieshou
Published: October 2022

Background

The inflammation and nutrition status are crucial factors influencing the outcome of patients with gastric cancer. This study aims to investigate the prognostic value of the preoperative prognostic nutritional index (PNI) in patients with stage I–III gastric cancer undergoing robotic radical gastrectomy combined with Enhanced Recovery after Surgery (ERAS), and further to create a clinical prognosis prediction model.

Study

525 patients with stage I–III gastric cancer who underwent ERAS combined with RRG from July 2010 to June 2018 were included in this work, and were divided randomly into training and validating groups in a 7-to-3 ratio. The association between PNI and overall survival (OS) was assessed by Kaplan-Meier analysis and the log-rank test. Independent risk factors impacting postoperative survival were analyzed with the Cox proportional hazards regression model. A nomogram for predicting OS was constructed based on multivariate analysis, and its predictive performance was evaluated using Harrell's concordance index (C-index), calibration plots, ROC curve, decision curve analysis (DCA), and time-dependent ROC curve analysis.

Results

Survival analyses revealed the presence of a significant correlation between low preoperative PNI and shortened postoperative survival (P = 0.001). According to multivariate analysis, postoperative complications (P < 0.001), pTNM stage (II: P = 0.007; III: P < 0.001), PNI (P = 0.048) and lymph node ratio (LNR) (P = 0.003) were independent prognostic factors in patients undergoing ERAS combined with RRG. The nomogram constructed based on PNI, pTNM stage, complications, and LNR was superior to the pTNM stage model in terms of predictive performance. The C-indexes of the nomogram model were respectively 0.765 and 0.754 in the training and testing set, while AUC values for 1-year, 3-year, and 5-year OS were 0.68, 0.71, and 0.74 in the training set and 0.60, 0.67, and 0.72 in the validation set.

Conclusion

Preoperative PNI is an independent prognostic factor for patients with stage I–III gastric cancer undergoing ERAS combined with robotic radical gastrectomy. Based on PNI, we constructed a nomogram for predicting postoperative outcomes of gastric cancer patients, which might be utilized clinically.