bluuebunny/crossref_metadata_2025 huggingface dataset:
Artificial Intelligence Islamic Architecture (AIIA): What Is Islamic Architecture in the Age of Artificial Intelligence?
Authors: Sukkar Ahmad W. , Fareed Mohamed W. , Yahia Moohammed Wasim , Mushtaha Emad , De Giosa Sami Luigi
Published: March 2024

Revisiting the long-debated question: “What is Islamic architecture?”, this research article aims to explore the identity of “Islamic architecture (IA)” in the context of artificial intelligence (AI) as well as the novel opportunities and cultural challenges associated with applying AI techniques, such as the machine learning of Midjourney in the context of IA. It investigates the impact factors of AI technologies on the understanding and interpretation of traditional Islamic architectural principles, especially architectural design processes. This article employs a quantitative research methodology, including the observation of works of artists and architectural designers appearing in the mass media in light of a literature review and critical analysis of scholarly debates on Islamic architecture, spanning from historical perspectives to contemporary discussions. The article argues for the emergence of a continuous paradigm shift from what is commonly known as “postmodern Islamic architecture” (PMIA) into “artificial intelligence Islamic architecture” (AIIA), as coined by the authors of this article. It identifies the following impact factors of AI on IA: (1) particular requirements and sensitivities, inaccuracies, and biases, (2) human touch, unique craftsmanship, and a deep understanding of cultural issues, (3) regional variation, (4) translation, (5) biases in sources, (6) previously used terms and expressions, and (7) intangible values. The significance of this research in digital heritage lies in the fact that there are no pre-existing theoretical publications on the topic of “Islamic architecture in the age of artificial intelligence”, although an extensive set of publications interpreting the question of the definition of Islamic architecture, in general, is found. This article is pivotal in analyzing this heritage-inspired design approach in light of former criticism of the definition of “Islamic architecture”, which could benefit both theorists and practitioners. This theoretical article is the first in a series of two sequential articles in the Buildings journal; the second (practical) article is an analytical evaluation of the Midjourney architectural virtual lab, defining major current limits in AI-generated representations of Islamic architectural heritage.
Gut–Brain Interactions and Their Impact on Astrocytes in the Context of Multiple Sclerosis and Beyond
Authors: Zißler Julia , Rothhammer Veit , Linnerbauer Mathias
Published: March 2024

Multiple Sclerosis (MS) is a chronic autoimmune inflammatory disease of the central nervous system (CNS) that leads to physical and cognitive impairment in young adults. The increasing prevalence of MS underscores the critical need for innovative therapeutic approaches. Recent advances in neuroimmunology have highlighted the significant role of the gut microbiome in MS pathology, unveiling distinct alterations in patients’ gut microbiota. Dysbiosis not only impacts gut-intrinsic processes but also influences the production of bacterial metabolites and hormones, which can regulate processes in remote tissues, such as the CNS. Central to this paradigm is the gut–brain axis, a bidirectional communication network linking the gastrointestinal tract to the brain and spinal cord. Via specific routes, bacterial metabolites and hormones can influence CNS-resident cells and processes both directly and indirectly. Exploiting this axis, novel therapeutic interventions, including pro- and prebiotic treatments, have emerged as promising avenues with the aim of mitigating the severity of MS. This review delves into the complex interplay between the gut microbiome and the brain in the context of MS, summarizing current knowledge on the key signals of cross-organ crosstalk, routes of communication, and potential therapeutic relevance of the gut microbiome. Moreover, this review places particular emphasis on elucidating the influence of these interactions on astrocyte functions within the CNS, offering insights into their role in MS pathophysiology and potential therapeutic interventions.
Deciphering Glioblastoma: Fundamental and Novel Insights into the Biology and Therapeutic Strategies of Gliomas
Authors: Onciul Razvan , Brehar Felix-Mircea , Toader Corneliu , Covache-Busuioc Razvan-Adrian , Glavan Luca-Andrei , Bratu Bogdan-Gabriel , Costin Horia Petre , Dumitrascu David-Ioan , Serban Matei , Ciurea Alexandru Vlad
Published: March 2024

Gliomas constitute a diverse and complex array of tumors within the central nervous system (CNS), characterized by a wide range of prognostic outcomes and responses to therapeutic interventions. This literature review endeavors to conduct a thorough investigation of gliomas, with a particular emphasis on glioblastoma (GBM), beginning with their classification and epidemiological characteristics, evaluating their relative importance within the CNS tumor spectrum. We examine the immunological context of gliomas, unveiling the intricate immune environment and its ramifications for disease progression and therapeutic strategies. Moreover, we accentuate critical developments in understanding tumor behavior, focusing on recent research breakthroughs in treatment responses and the elucidation of cellular signaling pathways. Analyzing the most novel transcriptomic studies, we investigate the variations in gene expression patterns in glioma cells, assessing the prognostic and therapeutic implications of these genetic alterations. Furthermore, the role of epigenetic modifications in the pathogenesis of gliomas is underscored, suggesting that such changes are fundamental to tumor evolution and possible therapeutic advancements. In the end, this comparative oncological analysis situates GBM within the wider context of neoplasms, delineating both distinct and shared characteristics with other types of tumors.
Peritraumatic Distress among Chinese Canadians during the Early Lockdown Stage of the COVID-19 Pandemic: Sociodemographic and Pandemic-Related Predictors
Authors: Katsiris Alexandra , Kandasamy Kesaan , Yang Lixia
Published: March 2024

The current study investigates the peritraumatic distress of Chinese residents living in Canada and identifies the associated sociodemographic and pandemic-related predictors during the initial phases of the Coronavirus Disease 2019 (COVID-19) pandemic lockdown (i.e., from April 2020 to June 2020). A final sample of 457 valid participants aged 18 or older completed an online survey in which peritraumatic distress was assessed with the COVID-19 Peritraumatic Distress Index (CPDI). The results showed 32.76% of the sample was in the mild to moderate range (i.e., 28–51) and 5.03% in the severe range (i.e., 52 to higher) for peritraumatic distress. The hierarchical regression models on the continuous CPDI score identified life satisfaction as a consistent protector for the CPDI (absolute values of βs = −1.21 to −0.49, ps < 0.001). After controlling for life satisfaction, the following sociodemographic risk factors were identified: being middle-aged, being employed (relative to retired people/students), living in Ontario (rather than elsewhere), and a poor health status. Furthermore, the following pandemic-related risk factors were identified: a higher self-contraction worry, more of a COVID-19 information authenticity concern, a higher future infection rate prediction, and a higher personal health hygiene appraisal. The results of our study shed light on cognitive, experiential, behavioural, and sociodemographic factors associated with peritraumatic distress for Chinese residents living in Canada during the early outbreak stage of the pandemic.
E-Coin-Based Priced Oblivious Transfer with a Fast Item Retrieval
Authors: Sebé Francesc , Simón Sergi
Published: March 2024

Priced oblivious transfer (POT) is a cryptographic protocol designed for privacy-preserving e-commerce of digital content. It involves two parties: the merchant, who provides a set of priced items as input, and a customer, who acquires one of them. After the protocol has run, the customer obtains the item they chose, while the merchant cannot determine which one. Moreover, the protocol guarantees that the customer gets the content only if they have paid the price established by the merchant. In a recent paper, the authors proposed a POT system where the payments employed e-coin transactions. The strong point of the proposal was the absence of zero-knowledge proofs required in preceding systems to guarantee the correctness of payments. In this paper, we propose a novel e-coin-based POT system with a fast item retrieval procedure whose running time does not depend on the number of items for sale. This is an improvement over the aforementioned existing proposal whose execution time becomes prohibitively long when the catalog is extensive. The use of zero-knowledge proofs is neither required.
A Retrospective Age Analysis of the Ambulatory Oncology Patient Satisfaction Survey: Differences in Satisfaction across Dimensions of Person-Centred Care and Unmet Needs among Older Adults Receiving Cancer Treatment
Authors: Strohschein Fay J. , Qi Siwei , Davidson Sandra , Link Claire , Watson Linda
Published: March 2024

Over half of all new cancer cases in Alberta are diagnosed among people aged 65+ years, a group that encompasses vast variation. Patient-reported experience measures are routinely collected within Cancer Care Alberta; however, the specific consideration of the needs and concerns of older Albertans with cancer is lacking. In 2021, 2204 adults who had received treatment at a cancer centre in Alberta completed the Ambulatory Oncology Patient Satisfaction Survey (AOPSS). In this study, we explored the age differences in satisfaction across six dimensions of person-centred care and in the proportions of unmet needs across eight types of issues, with specific attention to older adults. Using three age groups (18–39, 40–64, 65+), only the physical comfort dimension showed significantly lower satisfaction among those aged 65+ years. Using five age groups (18–39, 40–64, 65–74, 75–84, 85+), significantly lower levels of satisfaction were found related to ‘physical comfort’ for those aged 65–74 and 75–84, ‘coordination and continuity of care’ for those aged 75–84 and 85+, and ‘information, communication, and education’ for those aged 85+. Therefore, grouping together all older adults aged 65+ years obscured lower levels of satisfaction with some dimensions of person-centred care among those aged 75–84 and 85+ years. Unmet needs generally increased with age for all types of issues, with significant differences across age groups for emotional, financial, social/family, and sexual health issues. The lower levels of satisfaction and higher proportions of unmet needs call for tailored interventions to promote optimal care experiences and outcomes among older adults receiving cancer care in Alberta and their families.
Targeted Sequencing of Human Satellite 2 Repeat Sequences in Plasma cfDNA Reveals Potential Breast Cancer Biomarkers
Authors: Gezer Ugur , Oberhofer Angela , Worf Karolina , Stoetzer Oliver , Holdenrieder Stefan , Bronkhorst Abel
Published: March 2024

Liquid biopsies are revolutionizing the detection and management of malignant diseases. While repetitive DNA sequences, such as LINE-1 and ALU are established in cell-free DNA (cfDNA) research, their clinical applications remain limited. In this study, we explore human satellite 2 (HSATII), a prevalent repeat DNA sequence in plasma that exhibits increased levels in cancer patients, thereby positioning it as a potential pan-cancer biomarker. We employed targeted sequencing and copy number variation (CNV) analysis using two primer pairs to assess the differential abundance of HSATII sequences in the plasma of breast cancer patients compared to healthy individuals. PCR amplicons of HSATII from 10 patients and 10 control subjects were sequenced, generating 151 bp paired-end reads. By constructing a pooled reference dataset, HSATII copy ratios were estimated in the patients. Our analysis revealed several significant CNVs in HSATII, with certain sequences displaying notable gains and losses across all breast cancer patients, suggesting their potential as biomarkers. However, we observed pronounced fragmentation of cfDNA in cancer, leading to the loss of longer PCR amplicons (>180 bp). While not all observed losses can be attributed to fragmentation artifacts, this phenomenon does introduce complexity in interpreting CNV data. Notably, this research marks the first instance of targeted HSATII sequencing in a liquid biopsy context. Our findings lay the groundwork for developing sequencing-based assays to detect differentially represented HSATII sequences, potentially advancing the field of minimally-invasive cancer screening.
The Impact of Technology Teaching in the Dental Predoctoral Curriculum on Students’ Perception of Digital Dentistry
Authors: Nassani Leonardo M. , Bencharit Sompop , Schumacher Fernanda , Lu Wei-En , Resende Rodrigo , Fernandes Gustavo Vicentis Oliveira
Published: March 2024

The goal was to assess dental students’ perception of digital technologies after participating in a CAD/CAM exercise for scanning, designing, and manufacturing computer-aided provisional fixed dental restorations. A survey was conducted among second- (pre-D2 and post-D2), first- (D1, negative control), third-, and fourth-year dental students (D3 and D4, positive controls). Only OSU College of Dentistry students who completed the activity and completed the surveys were included. Seven questions were rated, which evaluated changes in knowledge, skill, interest, the importance of technology availability in an office, patients’ perception of technology, the importance of having the technology, and the expected frequency of clinics utilizing the technology. Statistical analysis was performed with a significance level of 0.05. A total of 74 pre-D2 and 77 post-D2 questionnaires were completed. Additionally, 63 D1, 43 D3, and 39 D4 participants responded to the survey. Significant differences were found for “knowledge” and “skill” between the pre-D2 and post-D2 and pre-D2 and control groups (p < 0.001). There was a significant difference between the post-D2 participants and all the controls in terms of “interest” (p = 0.0127) and preference for in-practice technology availability (p < 0.05). There were significant results between the post-D2 participants and all the controls regarding the importance of technology availability in an office (p < 0.001) and the expected frequency of clinics utilizing the technology (p = 0.01). No significance was found for “value of technology to patients” and “the importance of having the technology”. The presence of technology in practice and in educational academic environments significantly improved students’ interest and perception of their knowledge and skill.
Intra-Beam Interference Mitigation for the Downlink Transmission of the RIS-Assisted Hybrid Millimeter Wave System
Authors: Zhao Lou , Zhang Yuliang , Zhang Minjie , Liu Chunshan
Published: March 2024

Millimeter-wave (mmWave) communication systems leverage the directional beamforming capabilities of antenna arrays equipped at the base stations (BS) to counteract the inherent high propagation path loss characteristic of mmWave channels. In downlink mmWave transmissions, i.e., from the BS to users, distinguishing users within the same beam direction poses a significant challenge. Additionally, digital baseband precoding techniques are limited in their ability to mitigate inter-user interference within identical beam directions, representing a fundamental constraint in mmWave downlink transmissions. This study introduces an innovative analog beamforming-based interference mitigation strategy for downlink transmissions in reconfigurable intelligent surface (RIS)-assisted hybrid analog–digital (HAD) mmWave systems. This is achieved through the joint design of analog beamformers and the corresponding coefficients at both the RIS and the BS. We first present derived closed-form approximation expressions for the achievable rate performance in the proposed scenario and establish a stringent upper bound on this performance in a large number of RIS elements regimes. The exclusive use of analog beamforming in the downlink phase allows our proposed transmission algorithm to function efficiently when equipped with low-resolution analog-to-digital/digital-to-analog converters (A/Ds) at the BS. The energy efficiency of the downlink transmission is evaluated through the deployment of six-bit A/Ds and six-bit pulse-amplitude modulation (PAM) signals across varying numbers of activated RIS elements. Numerical simulation results validate the effectiveness of our proposed algorithms in comparison to various benchmark schemes.
Artificial-Intelligence-Based Clinical Decision Support Systems in Primary Care: A Scoping Review of Current Clinical Implementations
Authors: Gomez-Cabello Cesar A. , Borna Sahar , Pressman Sophia , Haider Syed Ali , Haider Clifton R. , Forte Antonio J.
Published: March 2024

Primary Care Physicians (PCPs) are the first point of contact in healthcare. Because PCPs face the challenge of managing diverse patient populations while maintaining up-to-date medical knowledge and updated health records, this study explores the current outcomes and effectiveness of implementing Artificial Intelligence-based Clinical Decision Support Systems (AI-CDSSs) in Primary Healthcare (PHC). Following the PRISMA-ScR guidelines, we systematically searched five databases, PubMed, Scopus, CINAHL, IEEE, and Google Scholar, and manually searched related articles. Only CDSSs powered by AI targeted to physicians and tested in real clinical PHC settings were included. From a total of 421 articles, 6 met our criteria. We found AI-CDSSs from the US, Netherlands, Spain, and China whose primary tasks included diagnosis support, management and treatment recommendations, and complication prediction. Secondary objectives included lessening physician work burden and reducing healthcare costs. While promising, the outcomes were hindered by physicians’ perceptions and cultural settings. This study underscores the potential of AI-CDSSs in improving clinical management, patient satisfaction, and safety while reducing physician workload. However, further work is needed to explore the broad spectrum of applications that the new AI-CDSSs have in several PHC real clinical settings and measure their clinical outcomes.
V2G Carbon Accounting and Revenue Allocation: Balancing EV Contributions in Distribution Systems
Authors: Yu Bingxuan , Lei Xiang , Shao Ziyun , Jian Linni
Published: March 2024

Accurate carbon emission accounting for electric vehicles (EVs) is particularly important, especially for those participating in the carbon market. However, the participation of numerous EVs in vehicle-to-grid (V2G) scheduling complicates the precise accounting of individual EV emissions. This paper presents a novel approach to carbon accounting and benefits distribution for EVs. It includes a low-carbon dispatch model for a distribution system (DS), aimed at reducing total emissions through strategic EV charging scheduling. Further, an improved carbon emission flow accounting model is proposed to calculate the carbon reduction of EVs before and after low-carbon dispatch. It enables real-time carbon flow tracking during EV charging and discharging, then accurately quantifies the carbon reduction amount. Additionally, it employs the Shapley value method to ensure equitable distribution of carbon revenue, balancing low-carbon operation costs and carbon reduction contributions. A case study based on a 31-node campus distribution network demonstrated that effective scheduling of 1296 EVs can significantly reduce system carbon emissions. This method can accurately account for the carbon emissions of EVs under different charging states, and provides a balanced analysis of EV carbon reduction contributions and costs, advocating for fair revenue allocation.
Radar Perception of Multi-Object Collision Risk Neural Domains during Autonomous Driving
Authors: Lisowski Józef
Published: March 2024

The analysis of the state of the literature in the field of methods of perception and control of the movement of autonomous vehicles shows the possibilities of improving them by using an artificial neural network to generate domains of prohibited maneuvers of passing objects, contributing to increasing the safety of autonomous driving in various real conditions of the surrounding environment. This article concerns radar perception, which involves receiving information about the movement of many autonomous objects, then identifying and assigning them a collision risk and preparing a maneuvering response. In the identification process, each object is assigned a domain generated by a previously trained neural network. The size of the domain is proportional to the risk of collisions and distance changes during autonomous driving. Then, an optimal trajectory is determined from among the possible safe paths, ensuring control in a minimum of time. The presented solution to the radar perception task was illustrated with a computer simulation of autonomous driving in a situation of passing many objects. The main achievements presented in this article are the synthesis of a radar perception algorithm mapping the neural domains of autonomous objects characterizing their collision risk and the assessment of the degree of radar perception on the example of multi-object autonomous driving simulation.
The High-Throughput Screening of Microorganisms to Eliminate Ethyl Carbamate in Chinese Liquor
Authors: Yin Zirui , Li Jianghua , Chen Jian , Du Guocheng , Zhao Xinrui
Published: March 2024

Ethyl carbamate (EC) is a 2A classified carcinogen in Chinese liquor that has raised many problems regarding food safety. Applying microorganisms to control the content of EC precursors in fermented grains has been proven as an effective method to reduce EC in alcoholic beverages. However, the utilization of microorganisms to decrease the precursors of EC (urea and cyanide) is still incomplete in regard to Chinese liquor. Thus, it is necessary to isolate strains with the degradative activities of urea and cyanide. Herein, Bacillus sonorensis F3 and Bacillus licheniformis YA2 strains were isolated from the fermented grains through multiple rounds of high-throughput screening, and the degradative abilities in urea and cyanide reached 95.72% and 75.48%, respectively. In addition, the urease from the B. sonorensis F3 strain and the carbon nitrogen hydrolase from the B. licheniformis YA2 strain were identified by the heterogeneous expression in Escherichia coli. Then, both F3 and YA2 strains were combined at a ratio of 5:1 and applied to eliminate the EC in the simulated fermentation of Chinese liquor; as a result, 51.10% of EC was reduced without affecting the main composition of flavor substances. The obtained strains have great potential in terms of the improvement of quality and safety of Chinese liquor.
Metabolomics-Based Analysis on the Effect and Metabolic Response of Mycelia by Sawdust Addition from Hypsizygus marmoreus
Authors: Li Jiahuan , Xie Jiacheng , Huang Zenan , Yang Peilei , Li Deng , Chen Liding , Sun Shujing
Published: March 2024

The composition of culture substrate is an important environmental factor that affects the growth and metabolism of Hypsizygus marmoreus, and sawdust is commonly used as the substrate for cultivating mushrooms. However, the influences of sawdust on metabolic level of H. marmoreus in mycelial growth is little reported. In this study, the effect of sawdust addition on mycelial growth rate, morphological characteristics and nutrient content of H. marmoreus was explored, and the metabolic response was analyzed based on LC-MS/MS. The results showed the mycelial growth rates and the number of mycelial clamp connections in sawdust medium A and sawdust medium B were significantly higher than that of the basic medium (Control). The mycelial morphology in sawdust medium A was denser, with higher edge trimness and stronger aerial mycelia. The contents of crude fiber, crude protein and polysaccharide of the mycelia from sawdust medium A increased by 85.15%, 90.65% and 92.61%, respectively, compared to that in the basic medium. A total of 551 metabolites were identified and obtained. The differential accumulated metabolites (DAMs) were mainly amino acids, lipids compounds and carbohydrates. It was speculated that the addition of sawdust played a vital role in promoting the cell division and, thus, the formation of clamp connections in H. marmoreus mycelia. Regarding amino acids, the metabolism of glycine, serine and ABC transporters was active with the increase in sawdust, thereby increasing the protein content. And some valuable bioactive molecules were found, such as docosahexaenoic acid (DHA). This study will lay the foundation for further research on the substance transformation and quality improvement of cultivation substrate for mushrooms.
Diverse Genotypes of Cronobacter spp. Associated with Dairy Farm Systems in Jiangsu and Shandong Provinces in China
Authors: Liu Hui , Ji Xing , Sun Haichang , Billington Craig , Hou Xiang , Soleimani-Delfan Abbas , Wang Ran , Wang Heye , Zhang Lili
Published: March 2024

Cronobacter spp. are the most concerning foodborne pathogen in infant formula milk powder. Currently, there are many reports on the prevalence of Cronobacter spp. in infant formula milk and its processing environment, but there are few studies on the prevalence of Cronobacter spp. on dairy farms. We have, therefore, undertaken this study to investigate and track genomic epidemiology of Cronobacter spp. isolates from Chinese dairy farms in the provinces of Jiangsu and Shandong. In this study, forty Cronobacter spp. strains, consisting of thirty Cronobacter sakazakii, eight Cronobacter malonaticus, and two Cronobacter dublinensis, were obtained from 1115 dairy farm samples (raw milk, silage, bedding, and feces), with a prevalence rate of 3.57%. These isolates were classified into 10 Cronobacter serotypes and 31 sequence types (STs), including three novel STs which were isolated for the first time. Notably, pathogenic Cronobacter STs 7, 8, 17, 60, and 64, which are associated with clinical infections, were observed. Antimicrobial susceptibility testing showed that all the Cronobacter spp. were highly resistant to cephalothin and fosfomycin, which was consistent with the antimicrobial genotype. All isolates carried core virulence genes related to adherence, invasion, endotoxin, immune evasion, secretion system, and regulation. Approximately half the isolates were also able to produce a strong biofilm. Twenty-one prophages and eight plasmids were detected, with the most common prophage being Cronobacter_ENT47670 and the most common plasmid being IncFIB (pCTU1). In addition, two isolates harbored the transmissible locus of stress tolerance (tLST) which confers high environmental persistence. Phylogenetic analysis showed strong clustering by species level and sequence types. Isolates from different sources or regions with a similar genomic background suggests the cross-contamination of Cronobacter spp. The presence of diverse genotypes of Cronobacter spp. in dairy farms in Jiangsu and Shandong provinces indicates that surveillance of Cronobacter spp. on dairy farms should be strengthened, to prevent and control transmission and ensure the quality and safety of raw dairy products.
New Results on (r,k,μ)-Riemann–Liouville Fractional Operators in Complex Domain with Applications
Authors: Tayyah Adel Salim , Atshan Waggas Galib
Published: March 2024

This paper introduces fractional operators in the complex domain as generalizations for the Srivastava–Owa operators. Some properties for the above operators are also provided. We discuss the convexity and starlikeness of the generalized Libera integral operator. A condition for the convexity and starlikeness of the solutions of fractional differential equations is provided. Finally, a fractional differential equation is converted into an ordinary differential equation by wave transformation; illustrative examples are provided to clarify the solution within the complex domain.
Treatment of Thoracic SMARCA4-Deficient Undifferentiated Tumors: Where We Are and Where We Will Go
Authors: Longo Vito , Catino Annamaria , Montrone Michele , Montagna Elisabetta Sara , Pesola Francesco , Marech Ilaria , Pizzutilo Pamela , Nardone Annalisa , Perrone Antonella , Gesualdo Monica , Galetta Domenico
Published: March 2024

Recently, the fifth edition of the WHO classification recognized the thoracic SMARCA4-deficient undifferentiated tumor (SMARCA4-UT) as a separate entity from conventional non-small cell lung cancer with SMARCA4 deficiency because of the different clinicopathological characteristics of these two diseases. SMARCA4-UT mainly occurs in young to middle-aged adults and involves a large mass compressing the tissues surrounding the mediastinum and lung parenchyma. Unfortunately, SMARCA4-UT shows a high probability of recurrence after upfront surgery as well as radiotherapy resistance; moreover, chemotherapy has low efficacy. Moreover, given the recent classification of SMARCA4-UT, no data concerning specific clinical trials are currently available. However, several case reports show immunotherapy efficacy in patients with this disease not only in a metastatic setting but also in a neoadjuvant manner, supporting the development of clinical trials. In addition, preclinical data and initial clinical experiences suggest that inhibiting pathways such as CDK4/6, AURKA, ATR, and EZH2 may be a promising therapeutic approach to SMARCA4-UT.
The Differences in the Developmental Stages of the Cardiomyocytes and Endothelial Cells in Human and Mouse Embryos at the Single-Cell Level
Authors: Liu Chuyu , Shao Ning-Yi
Published: March 2024

Our research focuses on expression patterns in human and mouse embryonic cardiomyocytes and endothelial cells at the single-cell level. We analyzed single-cell datasets containing different species, cardiac chambers, and cell types. We identified developmentally dynamic genes associated with different cellular lineages in the heart and explored their expression and possible roles during cardiac development. We used dynamic time warping, a method that aligns temporal sequences, to compare these developmental stages across two species. Our results indicated that atrial cardiomyocytes from E9.5 to E13.5 in mice corresponded to a human embryo age of approximately 5–6 weeks, whereas in ventricular cardiomyocytes, they corresponded to a human embryo age of 13–15 weeks. The endothelial cells in mouse hearts corresponded to 6–7-week-old human embryos. Next, we focused on expression changes in cardiac transcription factors over time in different species and chambers, and found that Prdm16 might be related to interspecies cardiomyocyte differences. Moreover, we compared the developmental trajectories of cardiomyocytes differentiated from human pluripotent stem cells and embryonic cells. This analysis explored the relationship between their respective developments and provided compelling evidence supporting the relevance of our dynamic time-warping results. These significant findings contribute to a deeper understanding of cardiac development across different species.
The Role of Neutral Sphingomyelinase-2 (NSM2) in the Control of Neutral Lipid Storage in T Cells
Authors: Schempp Rebekka , Eilts Janna , Schöl Marie , Grijalva Yépez Maria Fernanda , Fekete Agnes , Wigger Dominik , Schumacher Fabian , Kleuser Burkhard , van Ham Marco , Jänsch Lothar , Sauer Markus , Avota Elita
Published: March 2024

The accumulation of lipid droplets (LDs) and ceramides (Cer) is linked to non-alcoholic fatty liver disease (NAFLD), regularly co-existing with type 2 diabetes and decreased immune function. Chronic inflammation and increased disease severity in viral infections are the hallmarks of the obesity-related immunopathology. The upregulation of neutral sphingomyelinase-2 (NSM2) has shown to be associated with the pathology of obesity in tissues. Nevertheless, the role of sphingolipids and specifically of NSM2 in the regulation of immune cell response to a fatty acid (FA) rich environment is poorly studied. Here, we identified the presence of the LD marker protein perilipin 3 (PLIN3) in the intracellular nano-environment of NSM2 using the ascorbate peroxidase APEX2-catalyzed proximity-dependent biotin labeling method. In line with this, super-resolution structured illumination microscopy (SIM) shows NSM2 and PLIN3 co-localization in LD organelles in the presence of increased extracellular concentrations of oleic acid (OA). Furthermore, the association of enzymatically active NSM2 with isolated LDs correlates with increased Cer levels in these lipid storage organelles. NSM2 enzymatic activity is not required for NSM2 association with LDs, but negatively affects the LD numbers and cellular accumulation of long-chain unsaturated triacylglycerol (TAG) species. Concurrently, NSM2 expression promotes mitochondrial respiration and fatty acid oxidation (FAO) in response to increased OA levels, thereby shifting cells to a high energetic state. Importantly, endogenous NSM2 activity is crucial for primary human CD4+ T cell survival and proliferation in a FA rich environment. To conclude, our study shows a novel NSM2 intracellular localization to LDs and the role of enzymatically active NSM2 in metabolic response to enhanced FA concentrations in T cells.
Recent Advances in Synergistic Effect of Nanoparticles and Its Biomedical Application
Authors: Nanda Sitansu Sekhar , Yi Dong Kee
Published: March 2024

The synergistic impact of nanomaterials is critical for novel intracellular and/or subcellular drug delivery systems of minimal toxicity. This synergism results in a fundamental bio/nano interface interaction, which is discussed in terms of nanoparticle translocation, outer wrapping, embedding, and interior cellular attachment. The morphology, size, surface area, ligand chemistry and charge of nanoparticles all play a role in translocation. In this review, we suggest a generalized mechanism to characterize the bio/nano interface, as we discuss the synergistic interaction between nanoparticles and cells, tissues, and other biological systems. Novel perceptions are reviewed regarding the ability of nanoparticles to improve hybrid nanocarriers with homogeneous structures to enhance multifunctional biomedical applications, such as bioimaging, tissue engineering, immunotherapy, and phototherapy.
Turbomachinery Noise Review
Authors: Moreau Stéphane , Roger Michel
Published: March 2024

The present paper is aimed at providing an updated review of prediction methods for the aerodynamic noise of ducted rotor–stator stages. Indeed, ducted rotating-blade technologies are in continuous evolution and are increasingly used for aeronautical propulsion units, power generation and air conditioning systems. Different needs are faced from the early design stage to the final definition of a machine. Fast-running, approximate analytical approaches and high-fidelity numerical simulations are considered the best-suited tools for each, respectively. Recent advances are discussed, with emphasis on their pros and cons.
A Comprehensive Two-Decade Analysis of Lymphoma Incidence Patterns in Saudi Arabia
Authors: Basudan Ahmed M. , Althani Mohammed , Abudawood Manal , Farzan Raed , Alshuweishi Yazeed , Alfhili Mohammad A.
Published: March 2024

Background: Lymphomas account for approximately 10% of all cancer cases among the Saudi population. Even when separated, Hodgkin lymphoma (HL) and non-Hodgkin lymphoma (NHL) are in the top ten most commonly diagnosed cancers among Saudi men and women. Despite the substantial cost of HL and NHL to public health, the resources to assess their impact are insufficient. This study provides a two-decade detailed assessment of lymphoma incidence trends in the Saudi population. Methods: Analysis of the Saudi Cancer Registry (SCR) data for various incidence metrics from 2001 to 2020 was conducted. Joinpoint regression analysis was further performed to investigate temporal trends globally and by age group, gender, and administrative region. Results: HL cases grew by 174.1%, whereas NHL cases increased by only 80% for that time period. The HL overall Age-Standardized Incidence Rate (ASR) increased by 100% for both genders combined but remained unchanged for NHL. The median age at diagnosis for HL (20–30 years) and NHL (46–57 years) was lower than in many other nations. Our model identified increasing trends for HL with annual percentage changes (APCs) of 2.94% (CI: 2.2–3.7) and 3.67% (CI: 2.6–4.7) for males and females, respectively. The rise was mainly among young groups under 40. On the contrary, the NHL cohort revealed notable declining tendencies. We discovered alarming rates of HL in Saudi Arabia’s APC (2.23% for males and 3.88% for females) and ASR compared to other Western countries. Overall, the majority of the patients presented with advanced-stage disease at a younger age and with slight male predominance. Conclusions: The overall incidence of lymphoma (especially HL) has been rising among Saudis. Implementation of secondary and tertiary prevention measures, as well as management of modifiable risk factors, is warranted.
Do Patients with Benign Paroxysmal Positional Vertigo Have a Higher Prevalence of Osteoporosis? A Systematic Review and Meta-Analysis
Authors: Kim Chul-Ho , Kim Keunho , Choi Yeonjoo
Published: March 2024

Benign paroxysmal positional vertigo (BPPV) is a common vestibular disorder characterized by episodic vertigo. BPPV primarily affects older adults. Thus, understanding the potential relationship between BPPV and osteoporosis is clinically important. We performed a systematic search of MEDLINE (PubMed), Embase, and Cochrane Library databases for studies on the risk of osteoporosis between BPPV (+) and BPPV (−) groups up until 17 April 2023. We compared osteoporosis prevalence between groups and performed subgroup analyses for male, female, and older patients (aged ≥ 55 years). The 12 studies included 32,460 patients with BPPV and 476,304 controls. Pooled analysis showed that the BPPV (+) group had a significantly higher osteoporosis risk than the control group (odds ratio [OR], 1.73; 95% confidence interval [CI], 1.45–2.06; p < 0.01). Subgroup analyses also presented similar trends as male (OR, 2.41; 95% CI, 1.18–4.90; p = 0.02), female (OR, 2.14; 95% CI, 1.57–2.92; p < 0.001), and older patient subgroups (OR, 1.91; 95% CI, 1.47–2.49; p < 0.01) showed a higher osteoporosis risk in the BPPV (+) group than in the control group. This meta-analysis supports the hypothesis that patients with BPPV have a higher osteoporosis prevalence than those without.
Personalizing Nutrition Strategies: Bridging Research and Public Health
Authors: Clemente-Suárez Vicente Javier , Peris-Ramos Helia Carmen , Redondo-Flórez Laura , Beltrán-Velasco Ana Isabel , Martín-Rodríguez Alexandra , David-Fernandez Susana , Yáñez-Sepúlveda Rodrigo , Tornero-Aguilera José Francisco
Published: March 2024

In recent years, although life expectancy has increased significantly, non-communicable diseases (NCDs) continue to pose a significant threat to the health of the global population. Therefore, eating habits have been recognized as key modifiable factors that influence people’s health and well-being. For this reason, it is interesting to study dietary patterns, since the human diet is a complex mixture of macronutrients, micronutrients, and bioactive compounds, and can modulate multiple physiological processes, including immune function, the metabolism, and inflammation. To ensure that the data we acquired were current and relevant, we searched primary and secondary sources, including scientific journals, bibliographic indexes, and databases in the last 15 years with the most relevant articles. After this search, we observed that all the recent research on NCDs suggests that diet is a critical factor in shaping an individual’s health outcomes. Thus, cardiovascular, metabolic, mental, dental, and visual health depends largely on the intake, habits and patterns, and nutritional behaviors. A diet high in processed and refined foods, added sugars, and saturated fats can increase the risk of developing chronic diseases. On the other hand, a diet rich in whole, nutrient-dense foods, such as vegetables, fruits, nuts, legumes, and a high adherence to Mediterranean diet can improve health’s people.
When a New Pronoun Crosses the Border: The Spread of A Gente on the Brazilian-Uruguayan Frontier
Authors: Pacheco Cíntia , Carvalho Ana , Scherre Marta Pereira
Published: March 2024

This study shows that the incorporation of the first-person plural pronoun a gente has not only reached the southernmost tip of the Brazilian territory, but has crossed the border and entered Uruguayan Portuguese, or varieties of Portuguese spoken in northern Uruguay by Portuguese–Spanish bilinguals. This finding is based on the quantification of the a gente/nós variable in sociolinguistic interviews carried out in two border communities: Aceguá, Brazil, and Aceguá, Uruguay. The analysis of interviews recorded on each side of the border yielded a total of 1000 tokens that were submitted to a multivariate analysis. Following the premises of comparative sociolinguistics, we compared the distribution of the variable on both sides of the border and found that although Uruguayans used a gente less often than Brazilians, this innovation, preferred by young speakers, is incorporated in both dialects, following similar linguistic paths. These results show that Uruguayan Portuguese has incorporated the pronominal a gente in its grammar in a clear sign of convergence towards Brazilian Portuguese and divergence from Spanish, despite the coexistence with Spanish that categorically uses nosotros as the first-person plural pronoun and reserves the cognate la gente for its purely lexical meaning ‘the people’.
Benincasa hispida Alleviates Stress and Anxiety in a Zebrafish (Danio rerio) Model
Authors: Lakshmanagowda Nityashree Kyathegowdanadoddi , Sagar Niju , Puttasiddaiah Rachitha , Sridhar Kandi , Raghavendra Vinay Basavegowda , Bhaswant Maharshi
Published: March 2024

The Ayurvedic medical system uses fruits of the Benincasa hispida plant to treat mental diseases, including schizophrenia. The goal of the current study was to assess the aqueous extract of B. hispida fruit’s ability to relieve stress and anxiety induced in zebrafish models using neuropharmacological evaluation, which included determining behavioral parameters in tests such as the T-maze, open tank test (OTT), and light–dark preference test (LDPT). After measuring the zebrafish survival rate for 96 h, the LC50 was found to be 5 µg. AChE (acetylcholinesterase) inhibitory activity and the status of antioxidant enzymes (SOD, CAT, and LDH) were also used to evaluate the toxicity. Furthermore, the administration of the aqueous extract of B. hispida fruit increased the frequency of entry and duration of time spent in the bright section, suggesting a noteworthy reduction in levels of stress and anxiety. Additionally, the antistress and antianxiety activity was confirmed by the docking studies’ mechanism of action, which involves the AChE receptor binding stability of the homogalactaconan molecule found in the aqueous extract of B. hispida fruit. Overall, the findings of this study demonstrated that the aqueous extract of B. hispida fruit is a viable therapeutic molecule for the creation of novel drugs and the treatment of stress since it has the therapeutic advantage of reversing the negative effects of stress and anxiety.
Minimally Invasive Management and Diagnosis of Ectopic Splenic Pregnancy
Authors: Strakšytė Vestina , Mikšytė Rūta , Kulnickaitė Ugnė , Gudelevičius Simas
Published: March 2024

This report describes the case of a 32-year-old woman with ectopic pregnancy in the spleen, which was complicated by active bleeding. The patient complained of intermittent pain in her left side and lower abdomen that lasted several days. The serum beta-human chorionic gonadotropin (β-hCG) was increased, but no intrauterine gestational sac was found via transvaginal sonography. A computed tomography (CT) examination revealed the presence of a heterogeneous structure in the left peritoneal cavity, inferior to the spleen; signs of active extravasation; and a large amount of hemorrhagic fluid in the pelvis. An angiography examination also showed slow active extravasation from a small artery that branches off at the lower pole of the spleen. Coil embolization was performed. Splenic ectopic pregnancy can be managed by minimally invasive methods in carefully selected patients.
Study on the Process Window in Wire Arc Additive Manufacturing of a High Relative Density Aluminum Alloy
Authors: Wu Yajun , Li Zhanxin , Wang Yuzhong , Guo Wenhua , Lu Bingheng
Published: March 2024

In recent years, there has been a heightened focus on multiplex porosity due to its significant adverse impact on the mechanical properties of aluminum alloy components produced through wire arc additive manufacturing (WAAM). This study investigates the impacts of the process parameters and dimension parameters on the relative densities of WAAM 2219 aluminum alloy components by conducting experiments and investigates the changes in high relative density process windows with different dimension parameters. The findings reveal a hierarchy in the influence of various parameters on the relative density of the 2219 aluminum alloy: travel speed (TS), wire feed speed (WFS), the number of printed layers (L), interlayer cooling time (ICT), and theoretical length of weld (TLW). A series of data for analysis was produced through a designed experiment procedure, and on the basis of this, by integrating the data augmentation method with the eXtreme Gradient Boosting (XGBoost) algorithm, the relationship among the process parameters, dimension parameters, and relative density was modeled. Furthermore, through leveraging the established model, we analyzed the changes in the optimized process window corresponding to a high relative density with the L. The optimal windows of WFS and TS change when the L reaches a certain value. In contrast, the optimal window of ICT remains consistent despite an increase in the L. Finally, the relative density and mechanical properties of the formed 20-layer specimens within the model-derived window were verified. The relative density of the specimens within the window reached 98.77%, the ultimate tensile strength (UTS) reached 279.96 MPa, and the yield strength (YS) reached 132.77 MPa. This work offers valuable insights for exploring the process window and selecting process parameters through a more economical and faster approach in WAAM aluminum components.