bluuebunny/crossref_metadata_2025 huggingface dataset:
Primary osteosarcoma of the breast during lactation: a case report and literature review
Authors: Zhuo Huifang , Duan Yubei , Dong Shuangshuang , Zhang Jun , Wang Zijing , Meng Lian , Wang Chenyan , Li Man , Yang Xiaotian , Wang Ning , Hu Jianming
Published: November 2024

Primary osteosarcoma of the breast (POB) is an aggressive and exceedingly rare tumor, and cases with onset during lactation are extremely rare. The exact mechanism of POB development remains unclear. They may originate from totipotent mesenchymal cells in the breast stroma or may be the result of neoplastic transformation of prior breast lesions. Here, we present the case of a 40-year-old Chinese woman who was found with a palpable tumor measuring approximately 3 cm in diameter in her right breast while breastfeeding 4 months post-partum. The lactating woman was misdiagnosed with lactational mastitis during her initial visit to a community hospital. However, due to negative bacterial cultures and ineffective anti-infective treatment, later on the patient was taken to a more advanced hospital where a tissue biopsy was taken. The superior hospital considered that it might be a malignant tumor and performed local excision of the breast mass, leading to a final pathological diagnosis of POB. This is the first reported case of primary osteosarcoma during breastfeeding. We hope that this case report will improve readers’ understanding of the diagnosis and differential diagnosis of POB, especially for patients with atypical clinical symptoms and imaging findings, which should not be taken lightly.
Brachytherapy for cervical cancer: from intracavitary to interstitial technique
Authors: Yang Xiaojing , Ren Hanru , Li Zhen , Fu Jie
Published: November 2024

Cervical cancer is a common malignant tumor of female reproductive system. Radiation therapy is one of the main methods of cervical cancer treatment, of which brachytherapy is an essential and important part of radiation therapy for locally advanced cervical cancer. With the rapid development of imaging technologies such as computed tomography (CT) and magnetic resonance imaging (MRI), brachytherapy for cervical cancer has gradually developed from traditional two-dimensional image-guided technology to three-dimensional image-guided technology. And there are more and more treatment methods, including intracavitary brachytherapy, interstitial brachytherapy, and intracavitary combined interstitial implantation brachytherapy. We performed a PubMed search for introduce the application progress of intracavity, implantation, intracavity combined implantation brachytherapy and radioactive seed implantation, and discuss the dosimetric feasibility of internal and external fusion irradiation.
Identifying the quality markers and optimizing the processing of Gastrodiae rhizoma to treat brain diseases
Authors: Fu Yan , Xu Qingqing , Zhang Jinqiang , Kang Chuanzhi , Yang Changgui , Guo Lumei , Zhang Chenggang , Zhou Tao , Xiao Chenghong
Published: November 2024

Background

Gastrodiae rhizoma (GR) refers to the dried tuber of Gastrodia elata Bl. and has been used for many centuries to treat brain diseases, such as Alzheimer’s disease, major depressive disorder, and cerebral ischemia. However, the processing of GR is complex and varied, resulting in unstable clinical treatment effects. The processing protocols significantly affect the active ingredients and curative effects of GR. We can optimize the processing of GR by identifying quality markers to treat brain diseases.

Methods

Fresh tubers of G. elata Bl. were processed under eight different protocols, and their resulting contents of potentially bioactive compounds were compared using liquid chromatography mass spectrometry to screen the potential quality markers of GR through stoichiometric analysis. The potential quality markers of GR targeting Alzheimer’s disease, major depressive disorder, and cerebral ischemia were identified by network pharmacology, and the potentially neuroprotective effects of these components were validated through simulated docking to likely protein targets. Finally, a fit degree analysis was carried out using different composition ratios and proportions of the disease component degree value, and the therapeutic effects of different processing methods on Alzheimer’s disease, major depressive disorder, and cerebral ischemia were outlined clearly.

Results

We identified 32 potential therapeutic components and screened 13 quality markers in GR, of which five quality markers (galactinol, glucosyringic acid, parishins C and E, and S-(4-hydroxybenzyl)-glutathione) showed efficacy against all three brain diseases. Furthermore, steaming and microwave-drying during processing can optimize the components of these quality markers for treating the three diseases.

Conclusion

Processing protocols significantly affect the therapeutic components of GR and may also impact its effectiveness in treating brain diseases. Accordingly, optimizing the processing methods of GR to correspond to different therapeutic purposes may improve its efficacy against brain diseases.
The roles and patterns of critical care pharmacists: a literature review and practical operation model in China
Authors: Wei Chunyan , He Jinhan , Zhang Jingyi , Shan Huifang , Jiang Aidou , Liu Ying , Chen Guanghui , Xu Chaoran , Wang Linchao , Shao Xiaofen , Yin Wanhong
Published: November 2024

Drug-related problems (DRPs) are prevalent in critically ill patients and may significantly increase mortality risks. The participation of critical care pharmacists (CCPs) in the medical team has demonstrated a benefit to healthcare quality. Research indicates that CCP medication order evaluations can reduce DRPs, while their participation in rounds can reduce adverse drug events and shorten hospital stays. Pharmacist medication reconciliation often proves more effective than physicians, and CCPs play a crucial role in antimicrobial management and reducing treatment costs. Despite these benefits, there is a noticeable lack of practical guidance for implementing CCP roles effectively. Their workflow heavily influences the efficiency of CCPs. Integrating results from the literature with our practical experience, we have detailed workflows and critical entry points that CCPs can refer to. Pharmacists should be proactive rather than passive consultants. Pre-round medication order evaluations are crucial for determining the depth of a pharmacist’s involvement in patient care. These evaluations should cover the following aspects: medication indication, dosage, treatment duration, detection of DRPs, implementation of therapeutic drug monitoring, dosing of sedatives and analgesics, and pharmaceutical cost containment. Beyond identifying medication issues, a primary task during rounds is gathering additional information and building trust with the medical team. Post-round responsibilities for CCPs include patient and caregiver education on medication, medication reconciliation for transitioning patients, and follow-up care for post-ICU patients. Establishing a rationalized and standardized workflow is essential to minimize daily work omissions and maximize the pharmacist’s value. A multidisciplinary pharmacist-led team can significantly promote the rational use of antibiotics. Participation in post-ICU outpatient follow-ups can reduce drug-induced injuries after discharge. This review provides a detailed overview of the tasks performed by CCPs before, during, and after medical rounds, serving as a valuable reference for establishing an efficient workflow for CCPs.
Chemical adherence testing in the clinical management of hypertension: a scoping review
Authors: Rabbitt Louise , Curneen James , Dennedy Michael Conall , Molloy Gerard J.
Published: November 2024

Background

Despite growing use, questions remain surrounding the utility, acceptability and feasibility of chemical adherence testing (CAT) as part of hypertension management in clinical practice.

Objectives

This scoping review aimed to (i) identify and summarise studies using CAT in hypertension management, and (ii) describe and critically evaluate how CAT is currently being used in the clinical management of hypertension.

Eligibility criteria

Peer-reviewed and published studies in English, reporting original research in any setting, with any study design, were included. Search concepts included hypertension, medication adherence, CAT, and their synonyms.

Sources of evidence

Searches were carried out using Ovid Medline, EMBASE, and PsycInfo (EBSCO), alongside manual searching of reference lists. Using Covidence software, we screened titles and abstracts, followed by full-text articles. Data from the included articles were tabulated and summarised.

Results

Of the 618 studies identified, 48 were included. The studies cover diverse clinical settings, and were mostly observational in design. 7 studies reporting adherence analyses within clinical trials for hypertension therapies. The use of theoretical frameworks to guide reporting was rare, and there was considerable variation in key terminology and definitions, most notably in the definition of adherence.

Conclusion

The current body of evidence demonstrates considerable variability in the approach to implementing CAT for hypertension management in clinical practice, and a paucity of randomised controlled trials to evaluate its impact. Future research could (i) adopt a cohesive theoretical framework including clear operational definitions to standardise the approach to this important topic; (ii) further explore the impact of CAT on clinical outcomes using RCTs.
Utilizing the apical-out enteroids in vitro model to investigate intestinal glucose transport, barrier function, oxidative stress, and inflammatory responses in broiler chickens
Authors: Mann Peter , Liu Jundi , Yu Liang-en , Wolfenden Ross , Li Yihang
Published: November 2024

Introduction

Conventional 2D intestinal epithelial cell lines have been widely used in investigating intestinal functions, yet with limitations in recapitulating the in vivo gut physiology of chickens. A recently established chicken enteroid model with apical-out nature and the presence of leukocyte components represents intestinal mucosal functions. The objectives of this study were to 1) evaluate basic gut nutrient transport and barrier functions in this model and 2) identify the model’s effectiveness in studying inflammation and oxidative stress responses.

Methods

Enteroids were generated from individual villus units isolated from the small intestine of Cobb500 broiler embryos. Enteroid viability, morphology, and epithelial cell markers were monitored; barrier function was evaluated based on the permeability to fluorescein isothiocyanate–dextran (FD4) with or without EDTA and lipopolysaccharide (LPS) challenges; nutrient transport was evaluated by fluorescence-labeled glucose (2NBD-G) with or without transporter blockade; the oxidative status was indicated by reactive oxygen species (ROS). Inflammatory and oxidative challenges were induced by LPS and menadione treatment, respectively. Selected marker gene expressions, including tight junction proteins (CLDN-1, CLDN-2, ZO-1, and OCCL), epithelial cell markers (Lgr-5, LYZ, and MUC-2), cytokines (IL-1β, IL-6, IL-8, IL-10, TNF-α, and INF-γ), and antioxidant enzymes (Nrf-2, catalase, and SOD), were determined by using RT-qPCR. Data were analyzed by one-way ANOVA among treatment groups.

Results

Enteroid cell activity was stable from day (d) 2 to d 6 and declined at d 7. Epithelial cell marker and cytokine expressions were stable from d 4 to d 6. FD4 permeability was increased after the EDTA treatment (P ≤ 0.05). Transporter-mediated 2NBD-G absorption was observed, which was reduced with glucose transporter blockade (P ≤ 0.05). Enteroids showed classic responses to LPS challenges, including upregulated gene expressions of IL-1β and IL-6, downregulated gene expressions of ZO-1 and OCCL, and increased FD4 permeability (P ≤ 0.05). Enteroids showed increased ROS generation (P ≤ 0.05) in response to oxidative stress.

Discussion

In conclusion, this apical-out enteroid model is a stable alternative in vitro model that exhibits intestinal barrier, nutrient transport, oxidation, and inflammation functions. With this enteroid model, we developed two challenge protocols for evaluating intestinal functions under oxidative stress and inflammation conditions.
Mapping spatial memory in teleosts: a new Frontier in neural logging techniques
Authors: Takahashi Susumu , Sawatani Fumiya , Ide Kaoru , Abe Takaaki K. , Kitagawa Takashi , Makiguchi Yuya
Published: November 2024

Recent advancements in microelectromechanical system technology have significantly enhanced our ability to monitor neuronal activity in free-swimming fish without disrupting their natural movement, thereby greatly improving the capabilities of neural logging using “neurologger” technology. In this review, we compiled the findings from studies applying neurologgers to teleost fish, emphasizing the discovery of various spatial-cognition cells in regions of the telencephalon analogous to the mammalian hippocampus that are deeply involved in spatial navigation. We detailed how different fish species, such as goldfish and salmonids, correlate their neural activity with environmental boundaries, head direction, speed, and other navigational cues for spatial memory and navigation strategies. We critically analyzed the similarities and differences in these mechanisms to provide insights into the evolutionary aspects of spatial cognition. We also identified gaps in current methodologies and suggest directions for future research, emphasizing the need for further exploration of spatial encoding in aquatic environments. The insights gained herein suggest the existence of a complex and evolutionarily conserved substrate for navigation and memory in vertebrates, highlighting the potential of neurologgers to expand our understanding of spatial cognition.
Understanding cold stress response mechanisms in plants: an overview
Authors: Qian Zhenfeng , He Lilian , Li Fusheng
Published: November 2024

Low-temperature stress significantly impacts plant growth, development, yield, and geographical distribution. However, during the long-term process of evolution, plants have evolved complicated mechanisms to resist low-temperature stress. The cold tolerance trait is regulated by multiple pathways, such as the Ca2+ signaling cascade, mitogen-activated protein kinase (MAPK) cascade, inducer of CBF expression 1 (ICE1)-C-repeat binding factor (CBF)-cold-reulated gene (COR) transcriptional cascade, reactive oxygen species (ROS) homeostasis regulation, and plant hormone signaling. However, the specific responses of these pathways to cold stress and their interactions are not fully understood. This review summarizes the response mechanisms of plants to cold stress from four aspects, including cold signal perception and transduction, ICE1-CBF-COR transcription cascade regulation, ROS homeostasis regulation and plant hormone signal regulation. It also elucidates the mechanism of cold stress perception and Ca2+ signal transduction in plants, and proposes the important roles of transcription factors (TFs), post-translational modifications (PTMs), light signals, circadian clock factors, and interaction proteins in the ICE1-CBF-COR transcription cascade. Additionally, we analyze the importance of ROS homeostasis and plant hormone signaling pathways in plant cold stress response, and explore the cross interconnections among the ICE1-CBF-COR cascade, ROS homeostasis, and plant hormone signaling. This comprehensive review enhances our understanding of the mechanism of plant cold tolerance and provides a molecular basis for genetic strategies to improve plant cold tolerance.
Ionomic and proteomic changes highlight the effect of silicon supply on the nodules functioning of Trifolium incarnatum L.
Authors: Coquerel Raphaël , Arkoun Mustapha , Trouverie Jacques , Bernay Benoit , Laîné Philippe , Etienne Philippe
Published: November 2024

Introduction

Numerous studies have reported the beneficial effects of silicon (Si) in alleviating biotic or abiotic stresses in many plant species. However, the role of Si in Fabaceae facing environmental stress is poorly documented. The aim of this study is to investigate the effect of Si on physiological traits and nodulation efficiency in Trifolium incarnatum L.

Methods

Si was supplied (1.7 mM in the form of Na2SiO3) plants inoculated with Rhizobium leguminosarum bv trifolii and plant physiological traits and nodule ionomic and molecular traits were monitored over 25 days.

Results

Si supply promoted shoot biomass, the quantity of both Si and N in roots and shoots, and the number, biomass and density of nodules and their nitrogenase abundance which contribute to better dinitrogen (N2) fixation. Ionomic analysis of nodules revealed that Si supply increased the amount of several macroelements (potassium, phosphorus and sulfur) and microelements (copper, zinc and molybdenum) known to improve nodulation efficiency and N2 fixation. Finally, comparative proteomic analysis (+Si versus -Si) of nodules highlighted that Si modulated the proteome of both symbionts with 989 and 212 differentially accumulated proteins (DAPs) in the infected host root cells and their symbiont bacteria, respectively.

Discussion

Among the DAPs, the roles of those involved in nodulation and N2 fixation are discussed. For the first time, this study provides new insights into the effects of Si on both nodular partners and paves the way for a better understanding of the impact of Si on improving nodule function, and more specifically, on the nodules’ N2-fixing capacity.
RNA editing-induced structural and functional adaptations of NAD9 in Triticum aestivum under drought stress
Authors: Mohamed Nermin G. , Ramadan Ahmed M. , Amer Marwa , Morsy Yasser , Mohamed Rasha A. , Said Osama A. M. , Alnufaei Afnan A. , Ibrahim Mona I M. , Hassanein Sameh E. , Eissa Hala F.
Published: November 2024

Introduction

Mitochondria are essential organelles in eukaryotic cells, producing ATP through the electron transport chain to supply energy for cellular activities. Beyond energy production, mitochondria play crucial roles in cellular signaling, stress responses, and the regulation of reactive oxygen species. In plants, mitochondria are one of the keys to responding to environmental stresses which can significantly affect crop productivity, particularly in crops like wheat. RNA editing, a post-transcriptional RNA modification process in mitochondria, is linked to regulating these stress responses.

Methods

This study explores RNA editing patterns in the nad9 gene of wheat drought-tolerant (Giza168) and drought-sensitive (Gemmiza10) wheat cultivars under drought stress to understand plant adaptation mechanisms. RNA-seq data for these cultivars were analyzed using CLC Genomic Workbench to identify RNA editing sites in the nad9 gene, examining subsequent amino acid changes and predicting secondary structure modifications. These RNA editing sites were validated using qRT-PCR on drought-treated seedlings at 0, 2, and 12 hours post-treatment. Protein models were generated using AlphaFold, with functional predictions and structure verification conducted using various bioinformatics tools to investigate the effect of RNA editing on protein level.

Results

The results showed significant RNA editing events, especially C-to-T conversions, in the nad9 gene across different drought exposure times. Giza168 had 22 editing sites, while Gemmiza10 had 19, with several showing significant differences between control and stress conditions. RNA editing influenced the NAD9 protein's secondary structure, particularly beta sheets, and 3D modeling highlighted the structural impacts of these edits. The N-terminal region of NAD9 contained important regulatory motifs, suggesting a complex regulatory environment.

Discussion

This study reveals key editing sites that differ between drought-tolerant and sensitive wheat cultivars, impacting NAD9 protein structures and highlighting the role of RNA editing in enhancing drought resilience. Additionally, the study suggests potential regulatory mechanisms, including phosphorylation and ubiquitination that influence mitochondrial stability and function.
Gender differences in internet gaming among university students: a discriminant analysis
Authors: Gisbert-Pérez Júlia , Martí-Vilar Manuel , Merino-Soto Cesar , Chans Guillermo M. , Badenes-Ribera Laura
Published: November 2024

Introduction

Research on gaming and gaming habits has predominantly focused on younger populations, particularly males. The main objective of this study was to analyze gender-based differences in gamer profiles, considering variables related to gaming habits and the gaming community.

Methods

A total of 180 Spanish university students currently engaged in video gaming (M = 21.51 years, SD = 3.09, 57.4% male) participated in the study by completing an online questionnaire addressing gaming characteristics such as the age of onset, gaming hours, motives of gaming, and perceived toxicity in the video gaming community.

Results

The results revealed statistically significant gender differences in the age of gaming initiation, weekly gaming hours, community toxicity, and several gaming motivations, including customization, cognitive challenge, violent gratification, and social interaction. Linear discriminant analysis identified that higher scores in the age of initiation and customization, along with lower scores in violent gratification and community toxicity, formed the combination of predictor variables that most strongly distinguished between genders.

Conclusion

Understanding these gender differences is essential for capturing current gaming trends and addressing the needs of diverse gamers. Finally, the potential clinical implications of these findings are discussed.
Evaluating flourishing: a comparative analysis of four measures using item pool visualization
Authors: Ploke Veronika , Batinic Bernad , Stieger Stefan
Published: November 2024

The construct of flourishing, which refers to a high level of wellbeing, is a key concept in the field of positive psychology. Nevertheless, despite the proliferation of questionnaires attempting to measure wellbeing and flourishing, there is still an ongoing debate in the scientific community about the definition and assessment of both, which makes the choice of appropriate measures a major challenge. This study addresses this uncertainty through a comparative analysis of four widely used flourishing measures in a German-speaking sample, to enable researchers to make a reasonable choice among the measures available: the PERMA-Profiler, the Mental Health Continuum-Short Form, the Flourishing Scale, and the Wellbeing Conceptual Framework. To enhance the understanding of these four measures, we compared and contrasted the instruments using Item Pool Visualization (IPV), an illustrative approach that generates item pools from the same dataset and displays them as nested radar maps. Our research indicates that all four measures are useful in measuring the concept of flourishing. However, they differ from each other depending on specific interest (from a broader to a narrower view). If the aim is to get a comprehensive overview of flourishing, then the PERMA-Profiler, the Mental Health Continuum-Short Form, and the Flourishing Scale are appropriate options. If the focus is on measuring a more central concept, the Wellbeing Conceptual Framework provides the most specific assessment of flourishing.
A systematic review on robot-assisted language learning for adults
Authors: Deng Qi , Fu Changzeng , Ban Midori , Iio Takamasa
Published: November 2024

In the 21st-century era of globalization, language proficiency is a pivotal connector across cultures, with artificial intelligence (AI) revolutionizing educational paradigms through Robot-Assisted Language Learning (RALL). This systematic review examines the role of RALL in adult second language acquisition, focusing on its pedagogical strategies and learner engagement. Unlike the previous systematic reviews that explore the multifaceted roles of robots in language learning, including as teachers, tutors, assistants, and peer learners, we identify explicit and implicit instructional strategies within RALL, highlighting the unique learning landscape of adult learners characterized by self-regulation and self-direction. We assess the latest advancements in RALL for adult learners through three research questions, compare the effectiveness of explicit versus implicit instructions, and investigate affective factors enhancing RALL performance. Our review contributes a comprehensive status analysis, in-depth exploration of interaction modes, and insights for future research directions, providing a roadmap for academic research and practical guidance for educators and robot developers. This study aims to optimize RALL strategies to better meet the needs of adult learners, fostering a more efficient and engaging language learning experience.
Validation of the Brief Index of Sexual Functioning for women and men (BISF-W and BISF-M) in an Italian sample
Authors: Panzeri Marta , Ronconi Lucia , Fontanesi Lilybeth
Published: November 2024

Introduction

The Brief Index of Sexual Functioning for Women (BISF-W) is an international 4-factors tool assessing qualitative and quantitative aspects of sexual experiences in women, both in clinical and experimental settings. The present research aims at validating an Italian version of the BISF-W, to develop a BISF version for men (BISF-M) to fill the gap in the existing sexual function evaluation tools in Italy and to analyze gender and age groups differences in the BISF factors.

Methods

The research included 6,355 women, aged from 18 to 65 (M = 34.94, SD = 10.52) and 2,207 men, aged from 18 to 80 (M = 38.25, SD = 13.67), who completed the BISF-W and BISF-M. The Quality of Marriage Index (QMI) was administrated to both samples for testing divergent validity, while Female Sexual Function Index (FSFI) and the International Index of Erectile Function (IIEF) were administered for testing convergent validity. Correlation analysis, MANOVA between gender and age and Confirmatory Factor Analysis were conducted.

Results

The CFAs confirmed that the proposed 4-factor model (Dyadic, Solitaire and Anal Sexuality, and Sexual Difficulties) is suitable both for the BISF-W and the BISF-M, demonstrated strong psychometric properties for assessing sexual functioning in both genders, with dyadic sexuality being the most important factor. MANOVA analysis showed significative differences in the factors’ scores, according to gender and age.

Discussion

The BISF-W and the BISF-M are promising tools to address sexual functioning in individuals and couples, both in clinical and non-clinical settings. Gender and age differences are discussed regarding the potential use of BISF in the therapeutic context.
Attentional focus modulates physiological response to arousal in a competitive putting task
Authors: Rawls Bobby , Finomore Victor
Published: November 2024

Attentional focus during the execution of perceptual motor tasks has been shown to affect performance outcomes. The purpose of this study is to assess the physiological changes prompted by attentional focus in various levels of stress. Thirty-six healthy young males and females were randomized into groups and directed on attentional focus in a staged putting competition scenario intended to elicit competitive anxiety. External focus groups experienced less internal workload at all arousal levels and preserved heart rate variability measures when audiovisual distraction was introduced.
Effects of COVID-19 pandemic on psychiatric and psychological consultation-liaison contacts in a general hospital in North-East of Italy: a retrospective study
Authors: Prina Eleonora , Marquis Alice , Tedeschi Federico , Rabbi Laura , Salazzari Damiano , Ballarin Mario , Purgato Marianna , Ostuzzi Giovanni , Donisi Valeria , Perlini Cinzia , Rimondini Michela , Del Piccolo Lidia , Amaddeo Francesco
Published: November 2024

Background

The COVID-19 pandemic has prompted significant changes in healthcare, particularly affecting psychiatric and psychological Consultation-Liaison (CL) services in general hospital settings.

Aim

To assess the effects of COVID-19-related restrictions on utilization of psychiatric and psychological CL services in Northeast Italy during 2020, and to compare it to the use of services in the previous year (2019).

Methods

The study collected data on psychiatric and psychological consultations in 2019 and 2020 from a hospital database. It categorizes consultations by type of patient (inpatient or outpatient) and referral source (hospital wards, general practitioners, other specialists). Pandemic-related restrictions were classified as “lockdown,” “intermediate restrictions,” and “no or reduced restrictions” based on the Covid Stringency Index (CSI). Poisson regression models were employed to analyze the data.

Results

The findings reveal a significant 28% increase in the number of psychiatric and psychological consultations in 2020. Consultations for outpatients increased by 51%, while those for inpatients decreased by 11%. However, the lockdown and intermediate restriction phases were deemed responsible of a decrease of 42.9% and 19.5% in consultations respectively.

Discussion

This study highlights the persistent psychological burden during the COVID-19 pandemic, alongside reduced CL services due to lockdown measures. Integrating telemedicine into these types of services becomes imperative for meeting patient needs during restrictions. These findings can inform policies and practices to improve effective mental health care delivery during and beyond pandemics. Future research should explore the impact of pandemic-related restrictions on mental healthcare across settings and clinical factors affecting service accessibility.
Women with Premenstrual Dysphoric Disorder experiences of suicidal thoughts and behaviours: a mixed methods study
Authors: Brown Danielle , Smith Debbie M. , Osborn Elizabeth , Wittkowski Anja
Published: November 2024

Background

Women with Premenstrual Dysphoric Disorder (PMDD) experience debilitating psychological symptoms during each luteal phase of their menstrual cycle. Although women’s increased risk of suicidal thoughts and attempts to end their lives has been highlighted, little is as yet known about women’s own narratives. Therefore, this study aimed to explore the prevalence and the experiences of self-harm, suicidal thoughts and attempts in women with PMDD.

Method

In this mixed methods study, women’s experiences of living with PMDD were captured via an online survey exploring risk and via semi-structured interviews with questions informed by survey results. Data were analysed using descriptive statistics and reflexive thematic analysis.

Results

Over 3,600 women completed the survey between January and March 2020 and 14 women were subsequently interviewed in 2022. The survey revealed that just under half of women had deliberately harmed themselves during a PMDD crisis, 82% had suicidal thoughts on one or more occasions during their luteal phase, and 26% of women had attempted to end their own life. Three main themes, which related to suicidal ideation in the context of PMDD, were generated from the interview data: 1) personal relationships and social connections affected by PMDD, 2) the increase in suicidal experiences caused by diagnosis delays and 3) self-worth damaged by PMDD.

Conclusion

Women living with PMDD are at high risk of self-harm, suicidal thoughts and attempts to end their lives each month, narratives highlighted the damaging impacts PMDD had on relationships. Risk was increased by delays in appropriate medical support and women reported internalising their experiences as their problem.
Evidence of repeated zoonotic pathogen spillover events at ecological boundaries
Authors: Filion Antoine , Sundaram Mekala , Schmidt John Paul , Drake John M. , Stephens Patrick R.
Published: November 2024

Anthropogenic modifications to the landscape have altered several ecological processes worldwide, creating new ecological boundaries at the human/wildlife interface. Outbreaks of zoonotic pathogens often occur at these ecological boundaries, but the mechanisms behind new emergences remain drastically understudied. Here, we test for the influence of two types of ecosystem boundaries on spillover risk: (1) biotic transition zones such as species range edges and transitions between ecoregions and (2) land use transition zones where wild landscapes occur in close proximity to heavily impacted areas of high human population density. Using ebolavirus as a model system and an ensemble machine learning modeling framework, we investigated the role of likely reservoir (bats) and accidental host (primates) range edges and patterns of land use (defined using SEDAC categories) on past spillover events. Our results show that overlapping species range edges and heightened habitat diversity increase ebolavirus outbreaks risk. Moreover, we show that gradual transition zones, represent by high proportion of rangelands, acts as a buffer to reduces outbreak risks. With increasing landscape changes worldwide, we provide novel ecological and evolutionary insights into our understanding of zoonotic pathogen emergence and highlight the risk of aggressively developing ecological boundaries.
Research on healthcare data sharing in the context of digital platforms considering the risks of data breaches
Authors: Bai Shizhen , Zheng Jinjin , Wu Wenya , Gao Dongrui , Gu Xiujin
Published: November 2024

Background

Within China's healthcare landscape, the sharing of medical data has emerged as a pivotal force propelling advancements in the insurance sector and enhancing patient engagement with healthcare services. However, medical institutions often exhibit reluctance toward data sharing due to apprehensions regarding data security and privacy safeguards. To navigate this conundrum, our research introduces and empirically validates a model grounded in evolutionary game theory, offering a robust theoretical framework and actionable strategies for facilitating healthcare data sharing while harmonizing the dual imperatives of data utility and privacy preservation.

Methods

In this paper, we construct an evolutionary game model involving medical institutions, big data innovation platforms, and insurance companies within the context of digital platforms. The model integrates exogenous causes of data breaches, endogenous causes of data breaches, compensation payments, government penalties, subsidies, unreasonable fees, claims efficiency, and insurance fraud.

Results

The stability analysis of the evolutionary game identifies eight equilibrium points among medical institutions, platforms, and insurance companies. Numerical simulations demonstrate convergence toward strategy E7 = (0, 0, 1), suggesting a trend for medical institutions to adopt a fully anonymous information-sharing strategy, platforms to implement strict regulation, and insurance companies to opt for an auditing approach. Sensitivity analysis reveals that the parameters selected in this study significantly influence the players' behavioral choices and the game's equilibria.

Conclusions

When breaches occur, medical institutions tend to seek co-sharing between platforms and insurance companies. This promotes enhanced regulation by platforms and incentivizes insurance companies to perform audits. If the responsibility for the breach is attributed to the platform or the insurance company, the liability sharing system will push healthcare organizations to choose a fully anonymous information sharing strategy. Otherwise, medical institutions will choose partially anonymous information sharing for more benefits. In case of widespread data leakage, the amount of compensation shall augment, and the role of compensation shall replace the role of government supervision. Then, the government shall penalize them, which shall reduce the motivation of each subject.
Particulate matter pollution and older adult health: global trends and disparities, 1991–2021
Authors: Yi Qiong , Liu Min , Yan Dandan , Wang Xu , Meng Deqian , Li Ju , Wang Kai
Published: November 2024

Background

Particulate matter pollution (PMP) is a major global health concern, with the older adult being particularly vulnerable. This study aimed to analyze global trends in PMP-related deaths and disability-adjusted life years (DALYs) among the older adult from 1991 to 2021.

Methods

Using data from the Global Burden of Disease Study 2021, we examined the impacts of ambient particulate matter pollution (APMP) and household air pollution from solid fuels (HAP-SF). We analyzed trends across different regions, socioeconomic development levels, age groups, and genders.

Results

APMP-related older adult deaths increased from 1,745,000 to 3,850,000, and DALYs from 32,000,000 to 70,000,000. However, age-standardized mortality rate decreased from 384 to 337 per 100,000. HAP-SF-related deaths decreased from 2,700,000 to 2,100,000, and DALYs from 54,000,000 to 42,000,000. Age-standardized mortality rate for HAP-SF declined from 580 to 188 per 100,000. High APMP burden was concentrated in Asia, Africa, and the Middle East, while high HAP-SF burden was found in parts of Africa and South Asia. East Asia had the highest APMP-related older adult deaths (1,680,000) with an age-standardized mortality rate (ASMR) of 619 per 100,000. For HAP-SF, South Asia bore the heaviest burden with 1,020,000 deaths and an ASMR of 616 per 100,000. Females consistently experienced higher age-standardized DALYs rate than males for both APMP and HAP-SF across all regions and years. APMP burden showed a weak negative correlation with the Socio-demographic Index (SDI) at the regional level (r = −0.25, p < 0.001) but no significant correlation at the country level. HAP-SF burden exhibited strong negative correlations with SDI at both regional (r = −0.74, p < 0.001) and country levels (r = −0.83, p < 0.001).

Conclusion

Despite overall improvements, PMP continues to significantly impact older adult health globally, with substantial regional and gender disparities. These findings emphasize the need for targeted interventions, particularly in developing regions, and continued global efforts in air quality improvement and clean energy promotion.
Avoid overstepping the bounds of evidence: the role of the orthodontist in managing pediatric Obstructive Sleep Apnea
Authors: Rinchuse Daniel J. , Boggio Andrea , Manni Antonio , Cozzani Mauro
Published: November 2024

Introduction

Pediatric Obstructive Sleep Apnea (OSA) is a common sleep-related breathing disorder often linked to distinct craniofacial features and malocclusions. While orthodontic treatments, particularly maxillary expansion and mandibular advancement, have been suggested for managing this condition, the results remain controversial and are based on low-quality evidence. This paper aims to summarize the ongoing debates on this topic by reviewing relevant literature and highlighting the role of the orthodontist in diagnosing and managing OSA in daily clinical practice.

Discussion and conclusions

According to the present review, there is insufficient evidence to either confirm or deny the effectiveness of oral appliances for treating pediatric OSA due to significant methodological limitations, such as small sample sizes, inadequate control groups, short study durations, and a lack of long-term follow-up. Additionally, this condition cannot be diagnosed solely based on craniofacial morphology, but an interdisciplinary evaluation is strictly required. In addition, orthopedic treatment may be considered only as an adjunct therapy for children with craniofacial anomalies increasing the risk for OSA, and the combination of multiple therapeutic approaches may be necessary to achieve effective treatment outcomes.
Diagnostic performance of artificial intelligence in detecting oral potentially malignant disorders and oral cancer using medical diagnostic imaging: a systematic review and meta-analysis
Authors: Sahoo Rakesh Kumar , Sahoo Krushna Chandra , Dash Girish Chandra , Kumar Gunjan , Baliarsingh Santos Kumar , Panda Bhuputra , Pati Sanghamitra
Published: November 2024

Objective

Oral cancer is a widespread global health problem characterised by high mortality rates, wherein early detection is critical for better survival outcomes and quality of life. While visual examination is the primary method for detecting oral cancer, it may not be practical in remote areas. AI algorithms have shown some promise in detecting cancer from medical images, but their effectiveness in oral cancer detection remains Naïve. This systematic review aims to provide an extensive assessment of the existing evidence about the diagnostic accuracy of AI-driven approaches for detecting oral potentially malignant disorders (OPMDs) and oral cancer using medical diagnostic imaging.

Methods

Adhering to PRISMA guidelines, the review scrutinised literature from PubMed, Scopus, and IEEE databases, with a specific focus on evaluating the performance of AI architectures across diverse imaging modalities for the detection of these conditions.

Results

The performance of AI models, measured by sensitivity and specificity, was assessed using a hierarchical summary receiver operating characteristic (SROC) curve, with heterogeneity quantified through I2 statistic. To account for inter-study variability, a random effects model was utilized. We screened 296 articles, included 55 studies for qualitative synthesis, and selected 18 studies for meta-analysis. Studies evaluating the diagnostic efficacy of AI-based methods reveal a high sensitivity of 0.87 and specificity of 0.81. The diagnostic odds ratio (DOR) of 131.63 indicates a high likelihood of accurate diagnosis of oral cancer and OPMDs. The SROC curve (AUC) of 0.9758 indicates the exceptional diagnostic performance of such models. The research showed that deep learning (DL) architectures, especially CNNs (convolutional neural networks), were the best at finding OPMDs and oral cancer. Histopathological images exhibited the greatest sensitivity and specificity in these detections.

Conclusion

These findings suggest that AI algorithms have the potential to function as reliable tools for the early diagnosis of OPMDs and oral cancer, offering significant advantages, particularly in resource-constrained settings.

Systematic Review Registration

https://www.crd.york.ac.uk/, PROSPERO (CRD42023476706).
From stakeholders to protagonists: an exploratory framework for cultivating prosocial capacities for development
Authors: Hedley Darren Kirk
Published: November 2024

The world in 2024 faces numerous interlinked crises, including climate change and water shortages, rising geopolitical tensions, and a new awareness of the risks of pandemics. These crises reverse decades of incremental development progress and humanity’s aspirations embodied in the 2030 Agenda for Sustainable Development, necessitating a more active and collaborative participation of development stakeholders. The magnitude of challenges points to the need for transformational approaches to releasing the potential of stakeholders, which requires building on and extending beyond current best practices in participation and capacity strengthening. What is most needed today is a balanced assessment of the complexity of human nature and a vision that recognizes the prosocial potential of people to harmonize the pursuit of personal interests with a willingness to contribute to social and collective development goals. Prosociality is a capacity that all stakeholders can strengthen—from individuals to institutions to communities (including different forms of social groupings). These stakeholders can become empowered as active protagonists of development, with the potential to work synergistically to achieve the Sustainable Development Goals (SDGs). In order to work with these protagonists, it is important to view them systematically in terms of key characteristics such as their antecedent knowledge, values and culture, stance, agency, roles, relationships, and learning.
Backward test particle simulation of nonlinear cyclotron wave-particle interactions in the radiation belts
Authors: Hosseini Poorya , Harid Vijay , Gołkowski Mark , Tu Weichao
Published: November 2024

Wave-particle interaction plays a crucial role in the dynamics of the Earth’s radiation belts. Cyclotron resonance between coherent whistler mode electromagnetic waves and energetic electrons of the radiation belts is often called a coherent instability. Coherent instability leads to wave amplification/generation and particle acceleration/scattering. The effect of wave on particle’s distribution function is a key component of the instability. In general, whistler wave amplitude can grow over threshold of quasi-linear (linear) diffusion theory which analytically tracks the time-evolution of a particle distribution. Thus, a numerical approach is required to model the nonlinear wave induced perturbations on particle distribution function. A backward test particle model is used to determine the energetic electrons phase space dynamics as a result of coherent whistler wave instability. The results show the formation of a phase space features with much higher resolution than is available with forward scattering models. In the nonlinear regime the formation of electron phase space holes upstream of a monochromatic wave is observed. The results validate the nonlinear phase trapping mechanism that drives nonlinear whistler mode growth. The key differences in phase-space perturbations between the linear and nonlinear scenarios are also illustrated. For the linearized equations or for low (below threshold) wave amplitudes in the nonlinear case, there is no formation of a phase-space hole and both models show features that can be characterized as linear striations or ripples in phase-space.
From plate to waste: a cross-sectional study of food waste trends in Al Ahsa, Saudi Arabia
Authors: Al Khatib Alissar , Hassanein Salwa , Abdrbo Amany , Almari Mohammed , AL-Turaiki Sommanah M. , Alkhunaizi May , Antar Ahmad
Published: November 2024

Background

Food waste is a global concern that needs special attention and urgent actions to reduce the amount of wasted food. This study aims to investigate the trend of food waste in Al Ahsa.

Methods

This is a cross-sectional study designed to analyze the factors associated with the generation of wasted food within Al Ahsa community.

Results

The results showed that out of 257 participants, 82.9% were of Saudi nationality, 83.3% were females, 69.6% below 34 years and the family sizes mean was around 6. The majority of study participants were unemployed (62.3%), the employed ones were in healthcare field (56.4%). No significant gender differences was found in terms of other food waste-related variables. No significant association was found with age and occupation. Non-Saudi participants significantly report a lower frequency of wasting food and a higher rate of attitudes toward food waste sorting with p = 0.02 and p = 0.02, respectively. Working participants showed significant differences in terms of attitudes toward food waste sorting (p = 0.002), attitudes toward reducing food waste (p = 0.042), and the amount of food wasted per day (p = 0.010) when compared to those who are not working. Doctorate level of education exhibited significant (p = 0.002) attitudes toward food waste sorting and those who are in the commerce field of education had higher mean scores (M = 2.81, SD = 0.84) to reduce food waste. The cause of food waste was related to expiry date (61.1%). The common cause of wasting food when eating out or ordering online, was related to participants’ preference for trying a variety of dishes (40.1%). The participants adherent to home-cooked food during pandemic (mean 3.85, SD 1.40). Males reported a slightly higher impact of COVID-19 on their dietary habits when compared to females (p = 0.04). The majority of participants agreed that sharing food with neighbors decreases food waste (Mean = 3.96, SD = 1.32). Moreover, they do not throw food due to religious and cultural beliefs (Mean = 3.36, SD = 1.60).

Conclusion

Creating educational campaigns, promoting sustainable waste management and integrating technology to reduce food waste are recommended to achieve Saudi vision 2030.