bluuebunny/crossref_metadata_2025 huggingface dataset:
Assessment of Customers’ Relationship Management Practices on Customer Retention and Loyalty of Oromia Credit and Saving Share Company: Bule Hora City Branch
Authors: Chikako Teshita Uke , Hamu Gemedi Tesfaye
Published: June 2021

The main objective of this study was to assess customers’ relationship management practices of Oromia Credit and Saving Share Company, Bule Hora city branch in Bule Hora, Ethiopia. Customer relationship management (CRM) as a strategy has gained tremendous interest among researchers and practitioners in recent times. Thus, this study tried to assess the status and ways CRM has been put in for practice by Oromia Credit and Saving Share Company (OCSSCO). In addition, this study considers different CRM dimensions such as empathy, bonding and satisfaction, and responsiveness. To achieve the objective of the study, primary data were collected through a questionnaire from a sample of 246 Oromia Credit and Saving Share Company customers of Bule Hora city branch, Bule Hora, Ethiopia, by using simple random sampling technique. The data collected through the questionnaire were analyzed using descriptive statistical analysis method and inferential statistics by using SPSS version 20 as a tool of data analysis. The study clearly revealed that the four CRM dimensions are strongly related. Thus, from the perspective of customers as well as management bodies of the Oromia Credit and Saving Share Company, CRM has a significant influence on customer retention and loyalty of the organization. Generally speaking, microfinance institutions are in need of doing a lot of CRM-based customer-focused practices.
Geochemical Characteristics of the Middle Devonian Dacaozi-Tanshanping Shale Strata in the Yanyuan Basin, Southwest China: Implications for Organic Matter Accumulation and Preservation
Authors: Zhang Ziya , Yang Wei , Li Xingyu , Song Yan , Jiang Zhenxue , Luo Qun
Published: June 2021

How the geochemical characteristics of organic matter shale for the carbonate platform facies remain uncertain, which restricts an integrated reconstruction of the model of organic matter accumulation and preservation. Here, we present new results from element geochemical fingerprinting and integrated analyses of paleoclimate, paleoproductivity, paleoredox environment, and terrigenous input of the targeted Middle Devonian Tanshanping and Dacaozi Formations in the Ninglang-Yanyuan Basin, Southwest China. It is worth noting that although the carbonate platform connects with the open sea partially, the redox environment will not be completely controlled by relative sea level variations. Specially, the paleoclimate, paleoproductivity, and paleoredox conditions are the main controlling factors of the accumulation and preservation of organic matter. In view of the paleoclimate indexes, we suggest that both a relatively warm-humid climate characterized by intensified chemical weathering conditions and a higher terrigenous input are identified as two major drivers forcing the reductive environment in the sedimentary waterbody. Finally, a comprehensive model is established for providing new insights into the mechanism of organic matter accumulation and preservation for the carbonate platform facies. The paleoredox environment, paleoproductivity, paleoclimate, and terrigenous input are believed to have exerted a very considerable force on reconstructing the model of organic matter accumulation and preservation for the carbonate platform facies. Specially, the coupling interactions between the paleoproductivity and redox condition are thus also stressed. We found that the preservation condition is much more important than the paleoproductivity, resulting in the degree of organic matter enrichment. Even if the paleoproductivity of a sedimentary waterbody of a depositional period of the Dacaozi Formation was higher, the TOC concentrations were relatively low due to the poor preservation condition by fall of the sea level and increase of the terrigenous input. In another aspect, the better preservation condition of the Tanshanping Formation makes the TOC concentrations higher in the case of lower paleoproductivity in the sedimentary waterbody.
Real‐World Study of Cisplatin, Etoposide, and Bleomycin Chemotherapy Regimen in Gestational Trophoblastic Neoplasia
Authors: Wang Ming , Shen Lianna , Xu Xiaohong , Duan Wei , Miao Jinwei , Kong Weimin , Su Li , Wu Yumei
Published: June 2021

Objective. Little observational data exist regarding the use of cisplatin, etoposide, and bleomycin (BEP) chemotherapy regimen in patients with gestational trophoblastic neoplasia (GTN). Methods. This is a retrospective study of 95 patients with GTN in our center from June/2010 to June/2018. All patients received at least 2 cycles of BEP chemotherapy. The primary outcomes were the rate of complete remission (CR) and overall survival (OS). The secondary outcomes were disease‐free survival (DFS), pregnancy rates after BEP exposure, drug resistance rate, and other adverse events. Results. Of the 95 patients included, 66 (69.5%) patients received BEP as primary treatment and 29 (30.5%) were Salvage chemotherapy. The median age at diagnosis was 37 years (range 29.75‐46) and 34 years (range 27‐40) in two groups, respectively. The median WHO prognostic scores were 6 (range 3.5‐8), and 77.32% of patients were FIGO stage III‐IV in the primary treatment group. The median WHO prognostic scores were 5 (range 3‐9), and 66.55% of patients were FIGO stage III‐IV in the salvage treatment group. Median cycles of BEP treatment were 4 (3, 5) and 3 (2, 4) in two groups, respectively. In the primary chemotherapy group, 18.2% received additional hysterectomy, 4.5% received UAE for vaginal bleeding, and 1.52% received whole‐brain radiotherapy. In the salvage chemotherapy group, 20.7% received hysterectomy, 6.9% received lobectomy, 3.4% received hysteroscopic lesion resection, and 3.4% received whole‐brain radiotherapy. CR rates to initial chemotherapy were 86.4%, including 87.9% in the primary chemotherapy group and 82.8% in the salvage chemotherapy group. No predictive factor of chemotherapy resistance was identified. The rate of 5 year‐DFS was 96.52% (95% CI 86.78–99.12) in the primary chemotherapy group and 92.44% (95% CI 73.02‐98.06) in the salvage chemotherapy group. The rate of 5 year‐OS was 98.31% (95% CI 88.57–99.76) and 95.65% (95% CI 79.93‐99.38) in the two groups, respectively. During the treatment, neutropenia, thrombocytopenia, anemia, and liver dysfunction occurred in 80.3%, 6.1%, 25.8%, and 50% primary chemotherapy patients and 82.8%, 31%, 10.3%, and 86.2% salvage chemotherapy patients. In patients with fertility requirements, live birth rates were 100% (10/10) in primary chemotherapy patients and 80% (4/5) in salvage chemotherapy patients. Conclusions. BEP regimen was effective in the treatment of GTINs. The treatment was well tolerated, with no safety concerns on patients’ fertility.
Sirtuins: Potential Therapeutic Targets for Defense against Oxidative Stress in Spinal Cord Injury
Authors: Lin Jialiang , Xiong Zhencheng , Gu Jionghui , Sun Zhuoran , Jiang Shuai , Fan Dongwei , Li Weishi
Published: June 2021

Spinal cord injury (SCI) is one of the most incapacitating neurological disorders. It involves complex pathological processes that include a primary injury and a secondary injury phase, or a delayed stage, which follows the primary injury and contributes to the aggravation of the SCI pathology. Oxidative stress, a key pathophysiological event after SCI, contributes to a cascade of inflammation, excitotoxicity, neuronal and glial apoptosis, and other processes during the secondary injury phase. In recent years, increasing evidence has demonstrated that sirtuins are protective toward the pathological process of SCI through a variety of antioxidant mechanisms. Notably, strategies that modulate the expression of sirtuins exert beneficial effects in cellular and animal models of SCI. Given the significance and novelty of sirtuins, we summarize the oxidative stress processes that occur in SCI and discuss the antioxidant effects of sirtuins in SCI. We also highlight the potential of targeting sirtuins for the treatment of SCI.
Variability of SST and ILD in the Arabian Sea and Sea of Oman in Association with the Monsoon Cycle
Authors: Khan Sartaj , Piao Shengchun , Khan Imran U. , Xu Bingchen , Khan Shazia , Ismail Muhammad Asim , Song Yang
Published: June 2021

Sea surface temperature (SST) and isothermal layer depth (ILD) are important oceanic parameters and could play a significant role in understanding the upper thermal structure as well as improve the predictive capability of monsoons in the tropical oceans. In a disparate departure from the past research, the present study investigates the seasonal variability of SST and ILD in association with the monsoon cycle in the Arabian Sea and Sea of Oman regions by examination of Argo datasets for 2016-17. In this study, the ILD climatology is determined from temperature profiles provided by the Argo floats based on a threshold technique

T

z

≥
SST
−

1

°

C

 

to investigate the region of stronger and weaker monsoon wind forcing. For SST, values of temperature are used nearest to the sea surface (depth

z

≤

5 m). The region is split into four distinct zones for an accurate description of the monsoon cycle: the south Arabian Sea, the central Arabian Sea, the north Arabian Sea, and the Sea of Oman. It is observed that summer monsoon is more pronounced in the south-central basin of the Arabian Sea, where ILD is deepening (>100 m in September 2016) mainly due to stronger wind forcing in this region. On the contrary, the Sea of Oman region is displayed with smaller ILD amplitude (<10 m in June 2016) with larger SST, meaning that this region is weakly influenced by the summer monsoon. The seasonal relationship established between ILD variability and monsoon cycle for 2016-17 shows that ILD could be a useful indicator for predicting summer monsoon in the Arabian Sea regions. Our analysis results indicate that the dynamics for SST variability are different in these regions and are influenced either by large-scale atmospheric forcing, such as the El Niño-Southern Oscillation (ENSO) and the Indian Ocean Dipole (IOD), or by the effects of mesoscale variations occurring along the Oman-Arabian coast.
The Proteomic Landscape of Growth Factor Signaling Networks Associated withFAT1Mutations in Head and Neck Cancers
Authors: Chen Zhengjia , Zhang Chao , Chen Jianhong , Wang Dongsheng , Tu Jieqi , Van Waes Carter , Saba Nabil F. , Chen Zhuo G. , Chen Zhong
Published: June 2021

FAT1 is frequently mutated in head and neck squamous cell carcinoma (HNSCC), but the biological and clinical effects of FAT1 mutations in HNSCC remain to be fully elucidated. We investigated the landscape of altered protein and gene expression associated with FAT1 mutations and clinical outcomes of patients with HNSCC. FAT1 mutation was stratified with clinical information from The Cancer Genome Atlas HNSCC databases with more than 200 proteins or phosphorylated sites. FAT1 mutation was significantly more prevalent among HPV(−), female, and older patients and was enriched in oral, larynx, and hypopharynx primary tumors. FAT1 mutation was also significantly associated with lower FAT1 gene expression and increased protein expression of HER3_pY1289, IRS1, and CAVEOLIN1. From an independent International Cancer Genome Consortium dataset, FAT1 mutation in oral cancer co-occurred with top mutated genes TP53 and CASP8. Poorer overall survival or progression-free survival was observed in patients with FAT1 mutation or altered HER3_pY1289, IRS1, or CAVEOLIN1. Pathway analysis revealed dominant ERBB/neuregulin pathways linked to FAT1 mutations in HNSCC, and protein signature panels uncovered the heterogeneity of patient subgroups. Decreased pEGFR, pHER2, and pERK and upregulated pHER3 and HER3 proteins were observed in two FAT1 knockout HNSCC cell lines, supporting that FAT1 alterations lead to altered EGFR/ERBB signaling. In squamous cancers of the lung and cervix, a strong association of FAT1 and EGFR gene expressions was identified. Collectively, these results suggest that alteration of FAT1 appears to involve mostly HPV(−) HNSCC and may contribute to resistance to EGFR-targeted therapy.

Significance:

Integrative bioinformatics and statistical analyses reveal a panel of genes and proteins associated with FAT1 mutation in HNSCC, providing important insights into prospective clinical investigations with targeted therapies.
Association between Airport-Related Ultrafine Particles and Risk of Malignant Brain Cancer: A Multiethnic Cohort Study
Authors: Wu Anna H. , Fruin Scott , Larson Timothy V. , Tseng Chiu-Chen , Wu Jun , Yang Juan , Jain Jennifer , Shariff-Marco Salma , Inamdar Pushkar P. , Setiawan Veronica W. , Porcel Jacqueline , Stram Daniel O. , Le Marchand Loic , Ritz Beate , Cheng Iona
Published: June 2021

Ultrafine particles (UFP; diameter less than or equal to 100 nm) may reach the brain via systemic circulation or the olfactory tract and have been implicated in the risk of brain tumors. The effects of airport-related UFP on the risk of brain tumors are not known. Here we determined the association between airport-related UFP and risk of incident malignant brain cancer (n = 155) and meningioma (n = 420) diagnosed during 16.4 years of follow-up among 75,936 men and women residing in Los Angeles County from the Multiethnic Cohort study. UFP exposure from aircrafts was estimated for participants who lived within a 53 km × 43 km grid area around the Los Angeles International Airport (LAX) from date of cohort entry (1993–1996) through December 31, 2013. Cox proportional hazards models were used to estimate the effects of time-varying, airport-related UFP exposure on risk of malignant brain cancer and meningioma, adjusting for sex, race/ethnicity, education, and neighborhood socioeconomic status. Malignant brain cancer risk in all subjects combined increased 12% [95% confidence interval (CI), 0.98–1.27] per interquartile range (IQR) of airport-related UFP exposure (∼6,700 particles/cm3) for subjects with any address in the grid area surrounding the LAX airport. In race/ethnicity-stratified analyses, African Americans, the subgroup who had the highest exposure, showed a HR of 1.32 (95% CI, 1.07–1.64) for malignant brain cancer per IQR in UFP exposure. UFP exposure was not related to risk of meningioma overall or by race/ethnicity. These results support the hypothesis that airport-related UFP exposure may be a risk factor for malignant brain cancers.

Significance:

Malignant brain cancer risk increases with airport-related UFP exposure, particularly among African Americans, suggesting UFP exposure may be a modifiable risk factor for malignant brain cancer.
The Chronic Lymphocytic Leukemia Comorbidity Index (CLL-CI): A Three-Factor Comorbidity Model
Authors: Gordon Max J. , Kaempf Andy , Sitlinger Andrea , Shouse Geoffrey , Mei Matthew , Brander Danielle M. , Salous Tareq , Hill Brian T. , Alqahtani Hamood , Choi Michael , Churnetski Michael C. , Cohen Jonathon B. , Stephens Deborah M. , Siddiqi Tanya , Rivera Xavier , Persky Daniel , Wisniewski Paul , Patel Krish , Shadman Mazyar , Park Byung , Danilov Alexey V.
Published: June 2021

Purpose:

Comorbid medical conditions define a subset of patients with chronic lymphocytic leukemia (CLL) with poor outcomes. However, which comorbidities are most predictive remains understudied.

Experimental Design:

We conducted a retrospective analysis from 10 academic centers to ascertain the relative importance of comorbidities assessed by the cumulative illness rating scale (CIRS). The influence of specific comorbidities on event-free survival (EFS) was assessed in this derivation dataset using random survival forests to construct a CLL-specific comorbidity index (CLL-CI). Cox models were then fit to this dataset and to a single-center, independent validation dataset.

Results:

The derivation and validation sets comprised 570 patients (59% receiving Bruton tyrosine kinase inhibitor, BTKi) and 167 patients (50% receiving BTKi), respectively. Of the 14 CIRS organ systems, three had a strong and stable influence on EFS: any vascular, moderate/severe endocrine, moderate/severe upper gastrointestinal comorbidity. These were combined to create the CLL-CI score, which was categorized into 3 risk groups. In the derivation dataset, the median EFS values were 58, 33, and 20 months in the low, intermediate, and high-risk groups, correspondingly. Two-year overall survival (OS) rates were 96%, 91%, and 82%. In the validation dataset, median EFS values were 81, 40, and 23 months (two-year OS rates 97%/92%/88%), correspondingly. Adjusting for prognostic factors, CLL-CI was significantly associated with EFS in patients treated with either chemo-immunotherapy or with BTKi in each of our 2 datasets.

Conclusions:

The CLL-CI is a simplified, CLL-specific comorbidity index that can be easily applied in clinical practice and correlates with survival in CLL.
Combined EZH2 Inhibition and IKAROS Degradation Leads to Enhanced Antitumor Activity in Diffuse Large B-cell Lymphoma
Authors: Tong Kit I. , Yoon Sharon , Isaev Keren , Bakhtiari Mehran , Lackraj Tracy , He Michael Y. , Joynt Jesse , Silva Anjali , Xu Maria C. , Privé Gilbert G. , He Housheng Hansen , Tiedemann Rodger E. , Chavez Elizabeth A. , Chong Lauren C. , Boyle Merrill , Scott David W. , Steidl Christian , Kridel Robert
Published: June 2021

Purpose:

The efficacy of EZH2 inhibition has been modest in the initial clinical exploration of diffuse large B-cell lymphoma (DLBCL), yet EZH2 inhibitors are well tolerated. Herein, we aimed to uncover genetic and pharmacologic opportunities to enhance the clinical efficacy of EZH2 inhibitors in DLBCL.

Experimental Design:

We conducted a genome-wide sensitizing CRISPR/Cas9 screen with tazemetostat, a catalytic inhibitor of EZH2. The sensitizing effect of IKZF1 loss of function was then validated and leveraged for combination treatment with lenalidomide. RNA sequencing (RNA-seq) and chromatin immunoprecipitation sequencing analyses were performed to elucidate transcriptomic and epigenetic changes underlying synergy.

Results:

We identified IKZF1 knockout as the top candidate for sensitizing DLBCL cells to tazemetostat. Treating cells with tazemetostat and lenalidomide, an immunomodulatory drug that selectively degrades IKAROS and AIOLOS, phenocopied the effects of the CRISPR/Cas9 screen. The combined drug treatment triggered either cell-cycle arrest or apoptosis in a broad range of DLBCL cell lines, regardless of EZH2 mutational status. Cell-line–based xenografts also showed slower tumor growth and prolonged survival in the combination treatment group. RNA-seq analysis revealed strong upregulation of interferon signaling and antiviral immune response signatures. Gene expression of key immune response factors such as IRF7 and DDX58 were induced in cells treated with lenalidomide and tazemetostat, with a concomitant increase of H3K27 acetylation at their promoters. Furthermore, transcriptome analysis demonstrated derepression of endogenous retroviruses after combination treatment.

Conclusions:

Our data underscore the synergistic interplay between IKAROS degradation and EZH2 inhibition on modulating epigenetic changes and ultimately enhancing antitumor effects in DLBCL.
Chronic Myeloid Leukemia in a Patient with Hepatitis B Virus Infection: A Case Report
Authors: Ali Hailan Yousef Mohammed , Mudawi Deena , Yassin Mohamed A.
Published: June 2021

Chronic myeloid leukemia (CML) is a myeloproliferative disorder diagnosed by demonstrating the Philadelphia chromosome (Ph) or the BCR-ABL fusion gene. Tyrosine kinase inhibitors (TKIs) are the standard of therapy. There are increasing reports of hepatitis B virus reactivation (HBVr) in patients on this treatment. We report a case of a 46-year-old male patient diagnosed to have CML in the chronic phase and resolved hepatitis B infection. He was treated with imatinib as upfront therapy for CML and with lamivudine as prophylaxis against HBVr. The patient tolerated both treatments well with no adverse effects. The aim is to address the deficiencies in the literature in regard to managing these patients, prevention, and follow-up.
Successful Treatment with High-Dose Chemotherapy Followed by Autologous Stem-Cell Transplantation in a Patient with Metastatic Germ Cell Tumor
Authors: Lee Jung Min , Kang Byung Woog , Han Man-Hoon , Baek Dong Won
Published: June 2021

Although testicular germ cell tumors (GCTs) are known to curable disease even in cases with metastatic disease, patients in intermediate or poor-risk group may experience disease progression or refractory to the initial chemotherapy and needed second-line therapy. Long-term disease-free survival was unsatisfactory in relapsed/refractory patients with poor-risk factors and clinical trials for those patients are still insufficient. High-dose chemotherapy (HDCT) with stem-cell rescue may be an effective alternative for conventional chemotherapy-resistant patients who are eligible for transplantation. Herein, we present successful treatment experience with HDCT followed by autologous stem-cell transplantation in a severely ill patient with heavily pretreated metastatic GCT.
Acessibilidade informacional para pessoas com deficiência visual em uma biblioteca universitária
Authors: Castro Maria José Rodrigues de , Brasil Marcus Vinicius de Oliveira
Published: June 2021

Procura verificar se há acessibilidade informacional para pessoas com deficiência visual em uma biblioteca universitária, levando-se em consideração tipos de acessibilidade como a arquitetônica, comunicacional e instrumental. A pesquisa é um estudo de caso, complementado por revisão bibliográfica. Como instrumento de levantamento de dados, utilizou-se de checklist, que contempla itens referentes às normas e legislações inerentes à acessibilidade para pessoas com deficiência. É uma pesquisa de natureza aplicada, de caráter exploratório e descritivo. A abordagem dos dados é de natureza qualitativa. Com o estudo, a discussão sobre o tema chama atenção para práticas mais efetivas de acessibilidade informacional para pessoas com deficiência visual em bibliotecas universitárias e aspectos intrínsecos à função fim de disseminar a informação para um público específico. Conclui-se que a acessibilidade informacional na biblioteca pesquisada se dá de forma parcial, visto que o acesso efetivo à informação no espaço físico apresenta ausência de requisitos elencados nas normas e recomendações de acessibilidade, embora haja instrumentos adequados e convenientes para prestação de serviços e produtos informacionais adaptados para este público.
Elaboração do resumo documentário: qualidade, parâmetros e normas
Authors: Araújo Vanda de Jesus , Santos Cibele Araújo Camargo Marques dos
Published: June 2021

Apresenta pesquisa teórica e prática do processo de elaboração de resumos, produtos documentários que permitem o desenvolvimento da produção e disseminação científica. Procura sumarizar parâmetros existentes, verificar a contribuição e aplicação destes na estruturação do resumo em artigos científicos, e refletir sobre a qualidade dos resumos apresentados. Tal investigação justifica-se pelo fato de o resumo ser elemento pré-textual estudado pelo campo da Organização e Representação do Conhecimento que possibilita a eficiência da recuperação da informação. Para tanto, foram selecionados e analisados resumos de uma amostra de trinta e cinco artigos científicos. Após a análise da amostra, observou-se que os parâmetros normativos mínimos identificados foram pouco aplicados na redação dos resumos, sendo omitidas uma ou mais das quatro partes consideradas essenciais num resumo: objetivo, metodologia, resultados e conclusões. Conclui que os parâmetros existentes são generalistas e pouco exigidos, dificultando a produção de resumos que atendam bem sua finalidade.
Genetic Basis and Therapies for Vascular Anomalies
Authors: Queisser Angela , Seront Emmanuel , Boon Laurence M. , Vikkula Miikka
Published: June 2021

Vascular and lymphatic malformations represent a challenge for clinicians. The identification of inherited and somatic mutations in important signaling pathways, including the PI3K (phosphoinositide 3-kinase)/AKT (protein kinase B)/mTOR (mammalian target of rapamycin), RAS (rat sarcoma)/RAF (rapidly accelerated fibrosarcoma)/MEK (mitogen-activated protein kinase kinase)/ERK (extracellular signal-regulated kinases), HGF (hepatocyte growth factor)/c-Met (hepatocyte growth factor receptor), and VEGF (vascular endothelial growth factor) A/VEGFR (vascular endothelial growth factor receptor) 2 cascades has led to the evaluation of tailored strategies with preexisting cancer drugs that interfere with these signaling pathways. The era of theranostics has started for the treatment of vascular anomalies.

Registration:

URL:
https://www.clinicaltrialsregister.eu
; Unique identifier: 2015-001703-32.
Vascular and Lymphatic Malformations: Perspectives From Human and Vertebrate Studies
Authors: Janardhan Harish P. , Saheera Sherin , Jung Roy , Trivedi Chinmay M.
Published: June 2021

Vascular malformations, affecting ≈1% to 1.5% of the population, comprise a spectrum of developmental patterning defects of capillaries, arteries, veins, and/or lymphatics. The majority of vascular malformations occur sporadically; however, inherited malformations exist as a part of complex congenital diseases. The malformations, ranging from birthmarks to life-threatening conditions, are present at birth, but may reveal signs and symptoms—including pain, bleeding, disfigurement, and functional defects of vital organs—in infancy, childhood, or adulthood. Vascular malformations often exhibit recurrent patterns at affected sites due to the lack of curative treatments. This review series provides a state-of-the-art assessment of vascular malformation research at basic, clinical, genetic, and translational levels.
Network Meta-Analysis of Ticagrelor for Stroke Prevention in Patients at High Risk for Cardiovascular or Cerebrovascular Events
Authors: Bálint Alexandra , Tornyos Dániel , El Alaoui El Abdallaoui Oumaima , Kupó Péter , Komócsi András
Published: June 2021

Background and Purpose:

Preventive antiplatelet therapy is recommended for patients with cardiac or cerebrovascular atherosclerosis. Ticagrelor has an improved safety and efficacy profile in patients with acute coronary syndrome; however, data regarding stroke prevention remain controversial. We conducted a network meta-analysis to compare ticagrelor with other receptor antagonists (P2Y12) inhibitors and aspirin in monotherapy or combination in the treatment of patients with high risk for cardiovascular or cerebrovascular disease, defined as coronary artery disease, acute coronary syndrome, stroke or transient ischemic attack, or peripheral artery disease.

Methods:

Systematic searches of MEDLINE, EMBASE, and the Cochrane Library were conducted until August 1, 2020. Search terms included ticagrelor, AZD 6140, and stroke. The risk of bias was assessed using the Cochrane Collaboration assessment tool. Random-effects model was used to combine risk estimates across trials and risk ratio with 95% CIs served as summary statistics. The influence of individual components was evaluated in an additive network meta-analysis model. The primary efficacy end point was the occurrence of stroke. The safety end points included bleeding and all-cause mortality.

Results:

Twenty-six randomized clinical trials comprising 124 495 patients were analyzed. When compared with controls, ticagrelor plus aspirin significantly reduced the risk of ischemic stroke by 20% (risk ratio, 0.80 [95% CI, 0.71–0.89]). Treatment with ticagrelor monotherapy did not significantly affect ischemic stroke (risk ratio, 0.88 [95% CI, 0.77–1.00];
P
=0.05). Compared with aspirin alone, major bleeding was in similar ranges with antiplatelet monotherapies while the relative risk was twice higher with combined antiplatelet therapies. There was no considerable difference in the risk of mortality with ticagrelor plus aspirin (risk ratio, 0.99 [95% CI, 0.91–1.07]).

Conclusions:

Ticagrelor on top of aspirin may provide more favorable outcomes on secondary stroke prevention in patients with vascular risk factors; however, this benefit may come with the price of increased bleeding risk including intracranial bleeding.
Three new species of armoured scale insect (Hemiptera: Coccomorpha: Diaspididae) from Iran
Authors: MOGHADDAM MASUMEH
Published: June 2021

Three new species of armoured scale insect from Iran, namely Cryptoparlatoreopsis kermanensis sp. n., Diaspis quercus sp. n., and Hemiberlesia uramanica sp. n. are described and illustrated, based on morphology of the adult female. Identification keys to the world species of Cryptoparlatoreopsis and to the Iranian species of Diaspis and Hemiberlesia are provided.
A new giant anole (Squamata: Iguanidae: Dactyloinae) from southwestern Ecuador
Authors: AYALA-VARELA FERNANDO , VALVERDE SEBASTIÁN , POE STEVEN , NARVÁEZ ANDREA E. , YÁNEZ-MUÑOZ MARIO H. , TORRES-CARVAJAL OMAR
Published: June 2021

We describe a new species of Anolis lizard from the Pacific slopes of the Andes of southwestern Ecuador at elevations between 372–1,000 m. The new species belongs to the Dactyloa clade and may be distinguished from other Anolis by size, external anatomy, mitochondrial DNA divergence, and dewlap color. Based on phylogenetic analyses of mitochondrial and nuclear DNA sequence data, we found that the new species is sister to A. fraseri in a clade composed primarily of large Dactyloid species. The new species is known from a protected area in southern Ecuador, Buenaventura Reserve, which suggests that at least some its populations are well protected.
Review of Indian Dasyproctus Lepeletier & Brullé 1835 (Hymenoptera: Crabronidae) with description of four new species
Authors: BINOY C. , KUMAR P. GIRISH , SANTHOSH S.
Published: June 2021

The Indian species of the genus Dasyproctus Lepeletier & Brullé (Crabroninae: Crabronini: Crabronina) are reviewed resulting in the descriptions of four new species viz., D. attenboroughi, D. leclercqi, D. niger, and D. tsunekii. Keys to both sexes of Indian Dasyproctus are provided. Comparisons within D. buddha (Cameron) and D. agilis species groups allowed the withdrawing of Crabro (=Dasyproctus) idrieus Cameron from synonymy and raising D. agilis orientalis (Cameron) to full species status. Dasyproctus amplicarinalis Yue & Ma, 2021 is synonymized with D. idrieus (Cameron, 1901) and D. hainanensis Yue & Li, 2021 with D. geethae Binoy & Girish Kumar, 2021.
Anthrenus (s. str.) corona (Coleoptera, Dermestidae, Anthrenini): a new species in the A. pimpinellae Fabricius, 1775 complex from Turkey
Authors: HOLLOWAY GRAHAM J.
Published: June 2021

A new species from Turkey, Anthrenus (s. str.) corona, belonging to the Anthrenus pimpinellae complex is presented. The species is described from a single specimen discovered in the collection held by the Natural History Museum, London. The species was uncovered during the dissection of many specimens for the purpose of curation. The species is compared in detail to A. goliath, the most likely confusion species. An obvious external feature of the specimen is its large size, putting it apart from nearly all other species within the complex. The parameres and median lobe are slim, differing in many ways from A. goliath.
Towards an Ethics of Autism
Authors: Hens Kristien
Published: June 2021

What does it mean to say that someone is autistic?

Dynamics of Autism is an exploration of this question and many more. In this thoughtful, wide-ranging book, Kristien Hens examines a number of perspectives on autism, including psychiatric, biological, and philosophical, to consider different ways of thinking about autism, as well as its meanings to those who experience it, those who diagnose it, and those who research it. Hens delves into the history of autism and its roots in the work of Leo Kanner and Hans Asperger to inform a contemporary ethical analysis of the models we use to understand autism today. She explores the various impacts of a diagnosis on autistic people and their families, the relevance of disability studies, the need to include autistic people fully in discussions about (and research on) autism, and the significance of epigenetics to future work on autism.

Hens weaves together a variety of perspectives that guide the reader in their own ethical reflections about autism. Rich, accessible, and multi-layered, this essential reading for for philosophers, educational scientists, and psychologists who are interested in philosophical-ethical questions related to autism, but it also has much to offer to teachers, allied health professionals, and autistic people themselves.
9. Labels and Looping Effects
Authors: Hens Kristien
Published: June 2021

This chapter engages with the work of Erving Goffman, Ian Hacking, Gil Eyal and Dan Navon to describe the impact of classifications on people and the impact of people on classifications. Goffman described the phenomenon of stigma: how a label becomes part of how you and others understand yourself. Ian Hacking has investigated how classifications alter those classified and how those classified alter the classifications themselves, a phenomenon he calls the looping effect. Gil Eyal and Dan Navon have applied this idea to the association between genetic syndromes and autism. Although the relation between genes and autism seems straightforward – genes ‘explain’ autism – their paper demonstrates that other mechanisms contribute to classifications and objects of study.
UAS Current Mapping: A Wave-Based Heading and Position Correction
Authors: Lund Björn , Carrasco Ruben , Dai Hanjing , Graber Hans C. , Guigand Cédric M. , Haus Brian K. , Horstmann Jochen , Lodise John A. , Novelli Guillaume , Özgökmen Tamay , Rebozo Michael A. , Ryan Edward H. , Streßer Michael
Published: June 2021

Our unmanned aerial system (UAS) current mapping is based on optical video data of the sea surface. We use three-dimensional fast Fourier transform and least squares fitting to measure the surface waves’ phase velocities and the currents via the linear dispersion relationship. Our UAS is a low-cost off-the-shelf quadcopter with inaccurate camera position and attitude measurements, which may cause spurious currents as large as the signal. We present a novel wave-based UAS heading and position correction, improving the image rectification accuracy by a factor of ~3.5 and the current measurements’ temporal repeatability by factors of 1.8–4.8. This validation study maps the currents at high spatiotemporal resolution (5 m and 4 s) across the ~700-m-wide tidally dominated Bear Cut channel in Miami, Florida. The UAS currents are compared to flotsam tracks, obtained through automated UAS video object detection and tracking, drifter tracks, and acoustic Doppler current profiler measurements. The root-mean-square errors of the cross- and along-channel currents are better than 0.03 m s−1 for the flotsam comparison and better than 0.06 m s−1 for the drifter comparison; the latter revealed a 0.06 m s−1 along-wind bias due to wind- and wave-driven vertical current shear. UAS current mapping could be used to monitor river discharge, buoyant pollutants, or submesoscale fronts and eddies; the proposed wave-based heading and position correction enables its use in areas without ground control points.
Why People Turn to Institutions They Detest: Institutional Mistrust and Justice System Engagement in Uneven Democratic States
Authors: Hilbink Lisa , Salas Valentina , Gallagher Janice K. , Restrepo Sanín Juliana
Published: June 2021

Does political mistrust lead to institutional disengagement? Much work in political science holds that trust matters for political participation, including recourse to the justice system. Scholars of judicial institutions, relying largely on survey research, argue that low trust decreases legal compliance and cooperation, threatening the rule of law. Legal consciousness and mobilization scholars, meanwhile, suggest that trust does not drive justice system engagement. However, their single-case study approach makes assessing the wider implications of their findings difficult. Based on an innovative comparative focus-group study in two uneven democratic states, Chile and Colombia, we show that trust is not the primary factor driving justice system engagement. Rather, people’s engagement decisions are shaped by their expectations and aspirations for their political system and by their politically constructed capacities for legal agency. Our study offers insights of relevance for analysts of various forms of political participation in uneven democratic states across the globe.
Is a One-Way English Immersion Teaching Approach Equitable to Those Chinese Non-English Major Students from Rural Areas?
Authors: Yao Chunlin
Published: June 2021

English is a compulsory course for students in China from primary education to postgraduate education. Recently more and more policymakers at Chinese universities have been forcing English education to be performed using a one-way English immersion approach. In their views, the more English practices in English classes, the better the learners’ learning performance will be. This study adopts a hermeneutics research method, a questionnaire survey and some interviews to investigate the question whether a one-way English immersion teaching approach is equitable to those from rural areas. It finds that this teaching approach is inequitable to those from rural areas in at least three aspects, including increasing their economic burdens, decreasing their English acquisition confidences, and mismatching with their career requirements. The study calls for Chinese policymakers to alter their urban-centered viewpoints toward English education, and English teachers to enrich the English teaching approaches in the future and pay more attention to the future career requirements of those from rural areas.
Health Disparities Among Workers With Standing Position and Limited Restroom Access: A Cosmetics Saleswomen Study in South Korea
Authors: Choi Bokyoung , Kim Ji-Hwan , Yoon Jaehong , Lee Hyemin , Kim Seung-Sup
Published: June 2021

Korean cosmetics sales workers in department stores face harmful working environments, including limited restroom access, working long hours in a standing position, and customer violence. This study investigated health disparities between cosmetics saleswomen and the general population of working women in South Korea. We assessed the prevalence of health indicators, including physician-diagnosed disease, using a cross-sectional survey of 860 Korean cosmetics saleswomen in September 2018. Health indicators of cosmetics saleswomen were compared to those of general working women from the nationally representative datasets (e.g., National Health Insurance Service-National Sample Cohort). We estimated age-standardized prevalence ratios (SPRs) for health outcomes, including physical, mental, and health-related behavioral conditions. Cosmetics saleswomen were more likely to be diagnosed or treated for physical and mental conditions (e.g., cystitis SPR: 4.03, 95% confidence interval [CI]: 3.48-4.65; plantar fasciitis SPR: 23.48, 95% CI: 18.12-29.93; varicose vein SPR: 38.41, 95% CI: 32.18-45.49; and depression SPR: 11.18, 95% CI: 8.53-14.40) compared to general working women. Prevalence of smoking and hazardous alcohol consumption was also higher among cosmetics saleswomen than those of general women workers. Given our findings, further research is needed to identify work-related risk factors that could deteriorate cosmetic sales workers’ health in South Korea.
Researching Change and Changing: Integrating Collaboration and Action Through Interiority
Authors: (Rami) Shani Abraham B. , Coghlan David
Published: June 2021

In this essay, we are arguing that the field of organizational change and development is positioned to face the challenges of researching change and changing for the next decade and beyond. The core values in the field—that researching change and enacting changing are collaborative ventures undertaken in the present tense where the outcome is actionable knowledge, and that it serves the practical ends of organizations and generates the knowledge of how organizations change—are of utmost relevant for the emerging workplace and organizations. Through differentiated consciousness interiority challenges the polarizations that beset the field (between science and practice) and provides an integrative process focused on the operations of human knowing.
College Student Experiences of Grief and Loss Amid the COVID-19 Global Pandemic
Authors: Sirrine Erica H. , Kliner Olivia , Gollery Thomas J.
Published: June 2021

This study examined types of and reactions to loss experienced by a sample of 162 undergraduate and graduate students in the United States amid the COVID-19 global pandemic. Results indicated students reported an average of 6.33 losses with loss of normalcy being the most prominent. The number of losses experienced was a significant predictor of loss of control and avoidance. A significant positive relationship was revealed between spirituality and positive reappraisal whereas a significant negative correlation was identified between spirituality and loss of control and avoidance. Age was also negatively associated with expressions of avoidance and loss of control. Finally, students who attended faith-based institutions reported higher levels of positive reappraisal and lower levels of loss of control. Results suggest the need for educators and mental health practitioners to assess non-death losses among college students and provide supportive interventions aimed at promoting psychosocial-spiritual coping and resilience during and following a pandemic.
Proof of concept and feasibility of the app-based ‘#SWPMoveMore Challenge’: Impacts on physical activity and well-being in a police population
Authors: Oliver Helen , Thomas Owen , Copeland Robert James , Hesketh Ian , Jukes Matt , Chadd Kathryn , Rocca Marc
Published: June 2021

An app-based physical activity intervention (#SWPMoveMore Challenge) was completed by 239 workers from one UK police force using a quasi-experimental design. Impacts were assessed against minutes of movement, individual difference and work-related stress variables using quantitative and qualitative approaches. The concept was feasible and translatable to a UK police population and the intervention significantly benefited direct measures of physical activity and perceptions of vitality, job stress, job satisfaction, negative coping strategy use and engagement at work. The intervention was also motivational in helping individuals take-up and maintain physical activity and positively impacted morale and comradery within the work-force.
Citizens’ Opinion on Governmental Response to COVID-19 Outbreak: A Qualitative Study from Iran
Authors: Bagheri Lankarani Kamran , Honarvar Behnam , Kalateh Sadati Ahmad , Rahmanian Haghighi Mohammad Reza
Published: June 2021

Studying the people’s expectations of government measures to control and manage the coronavirus disease 2019 (COVID-19) can help to prepare for future crises. This study aimed to investigate the opinion of the Iranian people on authorities’ management during a crisis, such as the COVID-19 pandemic. This qualitative study was conducted on 70 Iranian citizens in Shiraz to explore their opinion about the government response to the COVID-19 outbreak in February and March 2020. Based on saturation criteria, the data was collected by 1 open-end question: “What is your attitude toward the readiness of the officials and government in this epidemic?” Thematic analysis was conducted to explore themes. At the first step of the outbreak, people had critical opinions on their authorities’ management. Four themes were studied, including trust and responsiveness, policymaking during a health crisis, economic management, and epidemic management. Although the citizens’ expectation is dynamic, our study showed that there are still high demands from citizens toward the authorities, even in a new crisis that was not perceived before. One of the best ways to respond to these demands is appropriate risk communication.
Examining the Association between Emotional Dysregulation and Treatment Burden
Authors: Schreiner Nathanial , Scherer Brooklynn , Al Battashi Hamed , Harwell Carla , Topalsky Vojislav , Burant Christopher , Daly Barbara , Douglas Sara , Woods Steven
Published: June 2021

Treatment burden contributes to suboptimal adherence and lower health-related quality of life among people diagnosed with chronic conditions, but little is known about how the psychological process of emotional dysregulation influences treatment burden. To explore this relationship, we conducted a descriptive, cross-sectional study comprised of 149 men and women diagnosed with one or more Centers for Medicare and Medicaid Systems defined chronic conditions recruited from a single primary care setting. Multivariate analyses demonstrated emotional dysregulation as an independent factor contributing to total ( p < .001), medication ( p = .007), and dietary ( p < .001) treatment burden, with model effect sizes ranging from large (.43) to moderate (.21), controlling for other known antecedent factors of treatment burden. Emotional dysregulation was not a factor contributing to exercise related treatment burden. Our findings indicated emotional dysregulation as an important factor contributing to higher levels of total, medication, and dietary treatment burden associated with daily self-management regimens.
Review of treatment and therapeutic targets in brain arteriovenous malformation
Authors: Pan Peipei , Weinsheimer Shantel , Cooke Daniel , Winkler Ethan , Abla Adib , Kim Helen , Su Hua
Published: June 2021

Brain arteriovenous malformations (bAVM) are an important cause of intracranial hemorrhage (ICH), especially in younger patients. The pathogenesis of bAVM are largely unknown. Current understanding of bAVM etiology is based on studying genetic syndromes, animal models, and surgically resected specimens from patients. The identification of activating somatic mutations in the Kirsten rat sarcoma viral oncogene homologue (KRAS) gene and other mitogen-activated protein kinase ( MAPK) pathway genes has opened up new avenues for bAVM study, leading to a paradigm shift to search for somatic, de novo mutations in sporadic bAVMs instead of focusing on inherited genetic mutations. Through the development of new models and understanding of pathways involved in maintaining normal vascular structure and functions, promising therapeutic targets have been identified and safety and efficacy studies are underway in animal models and in patients. The goal of this paper is to provide a thorough review or current diagnostic and treatment tools, known genes and key pathways involved in bAVM pathogenesis to summarize current treatment options and potential therapeutic targets uncovered by recent discoveries.