bluuebunny/crossref_metadata_2025 huggingface dataset:
THE ROLE POTENTIAL OF ARTIFICIAL INTELLIGENCE IN KNEE OSTEOARTHRITIS
Authors:   Department of Kinesitherapy, Faculty of Public Health, Healthcare and Sports, South-West University ", Subeva Petya ,   Neofit Rilski",   Blagoevgrad, Bulgaria., Gramatikova Mariya ,   Department of Kinesitherapy, Faculty of Public Health, Healthcare and Sports, South-West University "Neofit Rilski" Blagoevgrad, Bulgaria.
Published: October 2024

Purpose: The purpose of the study is to examine available scientific sources related to the role and potential of artificial intelligence in osteoarthritis of the knee joint. Materials/Methods: Method of deduction (analysis of literary sources). To achieve the goal, available scientific data on the role and potential of artificial intelligence application in knee OA were studied and analyzed. Results: The following innovations related to the use of artificial intelligence in knee osteoarthritis (OA) were reviewed: artificial intelligence (AI) software - named KOALA™ and DL AI software - MediAI-OA. KOALA™ is software that provides metric evaluations of knee joint imaging. Standardized quantitative measurements of morphological features such as joint gap width and joint gap area on knee radiographs reduce errors in diagnosis. The new DL software, MediAI-OA, demonstrated good success rates in analyzing knee OA characteristics, Kellgren-Lawrence (KL) grading (which is used to classify the severity of knee OA), and OA diagnosis comparable to that of experienced orthopedists and radiologists. Discussion: Diagnostic imaging is a vital tool for visualization. Imaging methods such as radiography, magnetic resonance (MR), computed tomography (CT), and ultrasound play critical roles in OA diagnosis. Additionally, vibro- and phono arthrography serve as alternative diagnostic tools. The most commonly used imaging method is magnetic resonance imaging, which has been found to underestimate the extent of osteochondral lesions. This can lead to inadequate and incomplete diagnoses. Artificial intelligence can serve as a strategic element in addressing these limitations in radiographic knee OA diagnosis. Conclusion: Artificial intelligence has the potential to advance the field of radiology by enhancing efficiency, accuracy, and precision in the radiographic diagnosis of knee osteoarthritis.
La prensa está dejando de publicar en Facebook. Evolución del posicionamiento de los diarios españoles en Facebook, 2014-2023
Authors: Díaz-Lucena Antonio
Published: October 2024

La red social Facebook cumplió en 2024 veinte años en funcionamiento y en la actualidad mantiene conectados mensualmente a tres millardos de usuarios. La prensa ha confiado desde el principio en esta plataforma para publicar su contenido informativo, que ha alcanzado una gran tasa de participación de la audiencia y cifras importantes de tráfico hacia sus páginas web desde Facebook. La presente investigación tiene como objetivo estudiar el posicionamiento que la prensa española (El País, El Mundo, ABC, La Vanguardia, El Español, elDiaro.es, El HuffPost y 20 Minutos) está desarrollando en esta plataforma para confirmar principalmente si ha habido variaciones entre 2014 y 2023 y cuál podría ser su estrategia a corto y largo plazo a raíz de los últimos acontecimientos que han impactado en esta red social. Se aborda la investigación con un enfoque mixto. En una primera fase se analiza cuantitativamente la evolución de la adquisición de seguidores, el número de publicaciones y las interacciones de la audiencia durante 10 años, desde el 1 de enero de 2014 hasta diciembre de 2023, con una muestra de N = 1.579.267 publicaciones. La segunda parte se centra en el análisis de datos cualitativos que se han recogido mediante una entrevista a los responsables de los medios seleccionados. Se concluye confirmando que la mayoría de los diarios de esta muestra están cambiando su estrategia en esta plataforma, principalmente por la dificultad de adquirir nuevos usuarios, pero también por la disminución de la tasa de involucramiento (engagement) de su comunidad.
Rezension von: Bopp, Marie-Joseph, Die evangelischen Geistlichen und Theologen in Elsaß und Lothringen
Authors: Lenckner Georg , Bopp Marie-Joseph
Published: October 2024

Marie Joseph Bopp: Die evangelischen Geistlichen und Theologen in Elsaß und Lothringen von der Reformation bis zur Gegenwart. Neustadt a. A.: Degener 1959. 709 S. 90 DM.
Rezension von: Sprandel, Rolf, Das Kloster St. Gallen in der Verfassung des karolingischen Reiches
Authors: Wunder Gerd , Sprandel Rolf
Published: October 2024

Rolf Sprandel: Das Kloster St. Gallen in der Verfassung des karolingischen Reichs. (Forschungen zur oberrheinischen Landesgeschichte 7.) Freiburg: Albert 1958. 151 S. 10 DM
Rezension von: von Teutleben, Valentin, Protokoll des Augsburger Reichstages 1530
Authors: Lenckner Georg , Valentin Hildesheim
Published: October 2024

Valentin von Tetleben: Protokoll des Augsburger Reichstages 1530. Herausgegeben von Herbert Grundmann. (Schriftenreihe der historischen Komission bei der bayerischen Akademie der Wissenschaften 4.) Göttingen 1958. 206 S. 23 DM.
Rezension von: Irtenkauf, Wolfgang, Hirsau
Authors: Schumm Karl , Irtenkauf Wolfgang
Published: October 2024

Wolfgang Irtenkauf : Hirsau, Geschichte und Kultur. (Thorbecke Kunstbücherei 7.) Konstanz: Thorbecke 1959. 40 S., 31 Abb. 8,50 DM.
Rezension von: Krauss, Paul, Gustav Werner
Authors: Lenckner Georg , Krauss Paul
Published: October 2024

Paul Krauß: Gustav Werner. Werk und Persönlichkeit. Zum 150. Geburtstag von Gustav Werner. 186 S., 8 Abb., 1 Lageplan. Reutlingen 1959 (Bruderhaus).
Rezension von: Poepelt, Konrad, Die Verschwägerung der Heimatvertriebenen mit den Westdeutschen
Authors: Wunder Gerd , Poepelt Konrad
Published: October 2024

Konrad Poepelt: Die Verschwägerung der Heimatvertriebenen mit den Westdeutschen. Neustadt a. A.: Degener 1959. 68 S, 7,50 DM.
AYURVEDIC APPROACHES FOR PROMOTING OCULAR HEALTH IN A TECHNOLOGY-DRIVEN ERA
Authors: Pushkar Dr. Savita , Chand Pamnani Dr. Gulab , Kumar Soni Dr. Rajendra , Srivastava Dr. Garima , Pushkar Dr. Ashok Kumar
Published: October 2024

Ocular disorders brought on by modern lifestyles have increased significantly, posing a serious threat to public health. The increased prevalence of ailments such dry eye syndrome, pterygium, digital eye strain, and age-related macular degeneration (ARMD) can be linked to bad lifestyle choices, environmental pollutants, and extended screen time. This essay investigates the potential of the traditional Indian medical practice of Ayurveda to avoid various eye conditions. The study highlights the value of ancient knowledge in modern healthcare by presenting a comprehensive strategy for preserving and improving eye health by incorporating Ayurvedic concepts and treatment techniques.
Virulence Mechanisms And Vaccine Development Strategies Against Leishmaniasis: An Evolving Battle
Authors: Maji Dr. Mithun
Published: October 2024

Leishmaniasis, a neglected tropical disease, is caused by more than 20 species of Leishmania and transmitted primarily by sand flies. It manifests in various forms, including cutaneous, mucocutaneous, visceral, and post kala-azar dermal leishmaniasis (PKDL). Visceral leishmaniasis (VL) is the most severe, affecting organs like the liver and spleen, while cutaneous and mucocutaneous forms cause skin ulcers and mucosal lesions, respectively. Leishmania parasites have evolved sophisticated virulence factors, such as lipophosphoglycan (LPG), GP63 protease, and elongation factor 1α (EF1α), to evade the host immune system and survive within macrophages. These virulence factors are critical targets for vaccine development. Second-generation vaccines have focused on recombinant antigens like gp63 and KMP-11, while third-generation vaccines explore DNA-based strategies targeting key Leishmania antigens. Despite promising results in preclinical studies, challenges such as immune evasion, genetic diversity, and variable host responses hinder universal vaccine efficacy. Continued research into virulence mechanisms and innovative vaccine approaches is essential to developing effective, safe, and widely applicable vaccines against leishmaniasis.
Strategies and Barriers to Technological Innovation in the Hospitality Industry: A Qualitative Exploration
Authors: Ersoy Aslı
Published: October 2024

Innovation is a concept that plays a crucial role in the success of the hospitality industry and provides many positive organizational outcomes. The concept of technological innovation in the hospitality industry has attracted great attention, especially due to the widespread impact of emerging technologies on organizations. The purpose of this study is to identify technological innovation strategies and challenges to successful innovation practices in the hospitality industry. 17 hospitality professionals worldwide, selected through convenience sampling, constitute the participant profile of this study. The current study, based on a qualitative research design, used text analysis to identify patterns in the data set. QSR NVivo 10 software was used to identify major themes from the transcripts. As a result of the analysis, 4 technological innovation strategies were identified, namely setting strategic direction, culture of innovation, organizational alignment and collaboration and partnerships, and 4 challenges were identified, namely lack of understanding technology, data overload, failure to meet user needs and the speed of change, which pose obstacles to innovation in the hospitality industry. This study contributes to innovation research in the hospitality literature by providing an in-depth evaluation of technological innovation strategies and the challenges in this process and approaching the topic holistically.
Frecuencia de cepillado y uso de pasta dental con flúor en niños de 4 a 6 años de edad en la parroquia Ricaurte del cantón Cuenca
Authors: Quezada Capelo Karelys , Moscoso Abad María Elizabeth , Saquisili Suquitana Sandra , Verdugo Tinitana Verónica
Published: October 2024

Objetivo: Determinar la frecuencia de cepillado y uso de pasta dental con flúor en niños de 4 a 6 años de edad, de la parroquia Ricaurte del cantón Cuenca. Materiales y Métodos: Se realizó un estudio descriptivo transversal de temporalidad actual, su universo fue de 1216 niños de 4 a 6 años de edad de la parroquia Ricaurte del cantón Cuenca. El tamaño de la muestra se calculó al cuantificar con un nivel de confianza del 95% y un margen de error del 5%, dando, una muestra de 233 niños, se aplicó la técnica de la encuesta para la toma de datos y estos se traspasaron a un software estadístico. Resultados: El 49.8% de los niños realizan el cepillado dental dos veces al día, el 42.9% utilizó una concentración de pasta dental de 1000 a 1100 ppm, el 67.8% aplicó la cantidad de pasta dental equivalente a un grano de alverja, el 61.8% de los padres tiene escolaridad secundaria y el 46.8% poseen un nivel de ingreso de $400 mensuales. Conclusión: La mayoría de los niños de 4 a 6 años de edad cepillan sus dientes dos veces al día, utilizando porcentajes de flúor de 1000 a 1100 ppm lo que corresponde a las concentraciones recomendadas por la asociación dental de odontología pediátrica.
Technological utilization of Bactris setosa mesocarp flour as a neurotransmitter stimulant
Authors: Silva Maria Madalena Conceição , Viana Diego Carvalho , Sampaio Carlos Fonseca , Soares Zilmar Timoteo
Published: October 2024

Difficulty in maintaining focus on tasks, motor agitation, impulsivity, and lack of attention are classic symptoms of attention deficit hyperactivity disorder (ADHD). Thus, the research aims to evaluate the chemical and nutritional effects of Bactris setosa (tucum) flour in different foods, further investigating whether these effects involve oxidative metabolism in the stimulation of neurotransmitter cells. The flour from the pulp of the tucum mesocarp was subjected to analysis of its physicochemical and nutritional aspects. The tucum pulp showed a yield of 25%, characterized by high levels of lipids, acetylcholine, vitamin C, B1, B5, and B6, zinc and calcium minerals, and a concentration of β-carotene, as well as being a source of fiber and carbohydrates. In the nutritional analyses, in 100g of tucum pulp flour, the following were found: energy 262 Kcal, carbohydrates 26.2g, proteins 2.1g, lipids 14.2g, fibers 12.2g, calcium 45.3mg, vitamin B1 36.7mg, vitamin B2 15mg, and vitamin B5 12.3mg. Therefore, further studies are necessary to verify whether diets with other proportions of Bactris setosa (tucum) used in supplementation could have beneficial effects on attention deficit.
Entrepreneurship in high school: exploring the potential of digital Information and Communication Technologies – DICT
Authors: Araujo Marcelo Marques , Veloso Leonardo Borges
Published: October 2024

Do DICT contribute to high school educational practices in the field of Entrepreneurship and Innovation? This investigation focused on teachers' practices to assess the impact of this integration, utilizing data collection methods such as focus groups and SWOT analysis. We analyzed positive impacts, resistance from teachers and students to DICT, the lack of technologies and programs for schools, among others.
Fluid disorders and acute kidney injury in myocardial revascularization
Authors: Cruz Guilherme Campelo , Silva Kamilla Grasielle Nunes , Duarte Tayse Tâmara da Paixão , Magro Marcia Cristina da Silva
Published: October 2024

This is a retrospective observational study. The data were extracted from the physical and electronic medical records of patients undergoing post-myocardial revascularization with extracorporeal circulation admitted to the Intensive Care Unit of a tertiary-level teaching hospital in the Brazilian Midwest region. To collect data, a questionnaire was used with demographic, hemodynamic and laboratory records from July 2022 to September 2023. Descriptive analysis was carried out and, due to lack of symmetry in the data; Fisher's exact test and Mann-Whitney's U test were used. Results with an α of 5% were considered significant. The 41 patients included were predominantly male, older adults, overweight and of black ethnicity. Patients with fluid deficit developed Acute Kidney Injury (AKI) more frequently (60%). Fluid overload predominated in the first postoperative periods and fluid deficit occurred later. In general, patients with fluid overload presented KDIGO 3 AKI (p<0.001). I was concluded that fluid overload and/or deficit appears to impact renal function. Patients with fluid deficit developed AKI more frequently. However, severe AKI (KDIGO 3) occurred significantly in patients with fluid overload.
Applications of Cytogenetics and Cytogenomics Evaluation techniques in cancer diagnosis: A review
Authors: Alhussain Ali Hassan , Alquwayi Waseem Ali , Alameer Alkuwaiti Yasser Abdrab , Almehainy Ahmed Mohammed , Alkhathami Adel Ahmed
Published: October 2024

Background: Cytogenetics and cytogenomics have revolutionized cancer diagnosis by revealing the underlying genetic alterations that characterize malignancies. The identification of chromosomal rearrangements, mutations, and DNA dosage abnormalities in cancer cells has enhanced our understanding of cancer as a genomic disease, enabling the detection of residual disease and improving patient prognosis. Aim: This review aims to explore the application of cytogenetic and cytogenomic evaluation techniques in cancer diagnostics. Methods: Through a detailed examination of traditional cytogenetic methods like karyotyping and fluorescence in situ hybridization (FISH), along with advanced genomic tools such as next-generation sequencing (NGS) and single-cell technologies, the review highlights their respective contributions to precision oncology. Findings: It also discusses the challenges posed by tumor heterogeneity and the need for individualized treatment approaches. The integration of cytogenetic and cytogenomic techniques provides critical insights into cancer heterogeneity, clonal evolution, and the identification of therapeutic targets, facilitating early diagnosis, prognosis, and personalized treatment plans. Conclusion: The advancement of high-throughput technologies has further accelerated the discovery of novel biomarkers, enhancing the precision of cancer diagnosis and treatment strategies.
Laboratory assessment of systemic lupus erythematosus
Authors: Alhussain Ali Hassan , Alquwayi Waseem Ali , Alkuwaiti Yasser Abdrab Alameer , Almehainy Ahmed Mohammed , Alkhathami ‏Adel Ahmed
Published: October 2024

Background: Systemic lupus erythematosus (SLE) is a multifaceted autoimmune disorder characterized by the production of autoantibodies and immune complexes, which play essential roles in its pathogenesis, diagnosis, and classification. Recent classification criteria emphasize the inflammatory nature of SLE, which is critical for assessing disease activity. Aim: This review article aims to evaluate the laboratory assessments utilized in diagnosing and monitoring SLE, with a specific focus on serological markers and their relation to inflammatory processes. Methods: A comprehensive review of current literature on SLE laboratory assessments, including serological markers such as autoantibodies, erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP), was conducted. Additionally, recent classification criteria from EULAR and ACR were analyzed to determine their implications for understanding SLE activity and inflammation. Results: The review found that inflammatory markers, particularly ESR, correlate with disease activity in SLE, while CRP levels may indicate bacterial infection rather than SLE activity. Furthermore, pro-inflammatory cytokines significantly contribute to the inflammatory manifestations seen in SLE. Conclusion: Laboratory assessments for SLE should emphasize inflammatory markers to enhance disease management. Integrating these markers with clinical features will improve diagnostic accuracy and provide a better understanding of SLE's inflammatory underpinnings.
The influence of celebrity endorsement on purchasing decisions for skincare products on social media for students of the Jember pharmacy Academy
Authors: Handojo Kukuh
Published: October 2024

Celebrity endorse is a method that uses celebrities as attractive figures in advertisements. The use of celebrities can be seen from the attractiveness, trustworthiness, and expertise of a public figure.Â  This study aims to determine the effect of celebrity endorsement on purchasing decisions for skincare products on social media for students of the Jember Academy of Pharmacy. The sample in this study were 75 respondents taken from students of the Jember Academy of Pharmacy. This sampling technique uses purposive sampling technique with data collection methods using a questionnaire. The data analysis used is the SEM-PLS (Partial Least Square) analysis method using SmartPLS software. The results of this study indicate that the attractiveness indicator does not have a positive and significant effect on purchasing decisions because the p-value is less than 0.05 and the t-statistic value is more than 1.96. Furthermore, the trust indicator shows the results of a p-value of 0.047 and the t-statistic of 1.990, which means that the trust indicator has a positive and significant effect on purchasing decisions. The expertise indicator shows that this indicator has a positive and significant effect on purchasing decisions because itÂ  has a p-value of 0.045 and the t-statistic of 2.010.
GAMBARAN PENGETAHUAN PASIEN TERHADAP HIPERTENSI DAN PENGOBATANNYA DI APOTEK AYU FARMA ROWOTENGAH KABUPATEN JEMBER
Authors: Rashati Dewi -
Published: October 2024

Â Â Â Â Â Â Â Â Â  Hypertension is an increase in systolic blood pressure of more than 140 mmHg and diastolic blood pressure of more than 90 mmHg on two measurements with intervals of five minutes in a fairly calm state. This study aims describe the patientâ€™s knowledge of hypertension and its treatment at the Ayu Farma Rowotengah Pharmacy, Jember Regancy. The research design was descriptive research regarding the description of the patient's knowledge of hypertension and treatment at the Ayu Farma Rowotengah Pharmacy. The research methods take a sample from a population and use a questionnaire as a tool data collector. Data collection was carried out by cross-sectional. This research carried out at the Ayu Farma Pharmacy Rowotengah RT.03 RW.05 Rowotengah Village, Sumberbaru District, Jember Regency will be implemented in June 2023. In this study, the samples were taken based on total sampling. Amount respondents in this study were 70 people who met the inclusion criteria. The conclusion regarding the description of the patient's knowledge of hypertension knows "Good" with a percentage of 81% with a good distribution of respondents 80%, sufficient 17%, and less than 3%. The result description of the patient's knowledge of treatment hypertension "Good" knowledge with a percentage of 82%, distribution of good respondents 60% and 40% sufficient.
Revisiones históricas, miradas ciudadanas y primera presidenta
Authors: Fernández Ana
Published: October 2024

Parece que, tras haber sido postergadas durante siglos, las mujeres ahora cobran protagonismo en la política. El objetivo de este texto es realizar una revisión sobre las consideraciones ciudadanas hacia las mujeres políticas, específicamente en relación con la presidencia de México. Para ello, se revisan encuestas de 1996 a nivel nacional, así como de 2012 y 2018, por sexo y edad, enfocadas en la Ciudad de México, además de otras fuentes consultadas para comparar la opinión pública al respecto. A esto se suman aproximaciones y reflexiones de obras, autoras y estudios sobre el tema, hasta llegar a las percepciones en las precampañas rumbo a las elecciones del 2024. Este texto aborda las percepciones ciudadanas y una revisión histórica reciente, no sobre mujeres en puestos específicos, sino sobre su apreciación desde la población. Los resultados muestran que la visión social hacia las mujeres en la política ha ido cambiando, favoreciendo su consideración en la misma. El valor de este trabajo radica en la aportación de información y datos sobre la historia contemporánea, y en la comparación de elecciones a lo largo de los últimos sexenios. Las conclusiones señalan que, tras un largo camino, en ocasiones por coyunturas, otras por luchas, a veces por intereses o convicciones, las mujeres no sólo acceden a más espacios en la política formal, sino que también están alcanzando la presidencia, con una visión más propositiva por parte de la ciudadanía y de sus compañeras/os de partido, en comparación con otras épocas de la historia del país.
Raíces
Authors: Naranjo Krishna
Published: October 2024

Una madre imagina morir.Pienso en las mujeres de leche,aquellas que se dan, sin tregua, a los reclamos del día.Se alivia el dolor con la luz de las antiguas,pero no hay remedio para las pequeñas bocasque desean el regazo del árbol, sombra y fruto.
Crucial Points of Subtextual Analysis in Contemporary Literary Criticism
Authors: Pasopati Rommel Utungga , Wijaya Kusuma , Andharu Devito , Fadillah Muhammad Reza Ishadi , Ananta Bintang Ryan
Published: October 2024

This paper explores the crucial aspects of subtextual analysis in contemporary literary criticism. Modern literary criticism tends to play on the definitional aspects of literary works, but subtextual analysis goes beyond by regarding implied meanings. The idea is that meanings are waiting to be revealed by the audience. Through explorative approach and qualitative method, the analysis of this article revolves on the strategies, the critical roles, and the instance of subtextual analysis in literary analysis. The strategies of subtextual analysis involve engaging the audience to foster a personal connection with literary works, synthesizing and correlating meanings within literary works, encompassing empathetic engagement with the narrative, and developing diverse perspectives from the audience's vantage point. The critical roles of subtextual analysis consist of facilitating deeper implications through insinuated meanings, enhancing meanings in intrinsic and extrinsic dimensions of literary works, unveiling repressions presented within the text, facilitating exploration of anticipated interpretations and underlying meanings, adopting interdisciplinary approach, engaging with societal dimensions of literary works, perceiving literary works beyond any definition, and propelling co-texts, hypertexts, hypo-texts, and intertexts. In conclusion, subtextual analysis underlines possibilities in literary analysis by comparing various implied meanings related to humans’ identities in particular.
Jogo de tabuleiro “Casa Project”: aprendizado baseado em jogos como uma metodologia ativa no ensino técnico
Authors: Mazziolli Sollyvan Rangel , Avelar Marcela Giacometti de
Published: October 2024

O Instituto Federal do Espírito Santo – Campus Nova Venécia oferece cursos técnicos e de nível superior, destacando-se o Ensino Médio integrado ao Curso Técnico em Edificações, pertencente ao eixo tecnológico de infraestrutura. No entanto, muitos alunos enfrentam dificuldades significativas nas disciplinas técnicas, principalmente devido à falta de uma base sólida de conhecimento na área. Para enfrentar esse desafio, foi desenvolvido o jogo de tabuleiro "Casa Project", como parte do Mestrado Profissional em Educação Profissional e Tecnológica (ProfEPT), visando integrar de maneira lúdica e prática os conteúdos técnicos do curso. O jogo simula todas as etapas da construção de uma casa, permitindo que os alunos vivenciem situações reais do cotidiano da construção civil. O objetivo é dinamizar o processo de ensino e aprendizagem, utilizando metodologias ativas para melhorar a assimilação dos conhecimentos técnicos. A aplicação do jogo demonstrou melhorias significativas na compreensão dos alunos, aumentando seu engajamento e motivação. A abordagem inovadora e lúdica proposta pelo "Casa Project" evidencia o potencial das metodologias ativas em promover uma aprendizagem significativa e inclusiva, preparando os alunos para os desafios do mercado de trabalho na construção civil. Recomenda-se a continuidade e expansão do uso de jogos educativos no ensino técnico, ajustando-os conforme o feedback dos alunos para maximizar seus benefícios educacionais.
Inovações interdisciplinares em adjuvantes terapêuticos para a quimioterapia oncológica: fluxo de desenvolvimento de um nanocomplexo funcional de origem natural
Authors: Sousa Ian Jhemes Oliveira , Barbosa Bruno de Sousa , Nogueira Kerolayne de Melo , Ferreira Paulo Michel Pinheiro , Oliveira Rita de Cássia Meneses
Published: October 2024

Esta revisão destaca as descobertas interdisciplinares emergentes na criação de coad-juvantes terapêuticos para mitigar as complicações da quimioterapia oncológica, com foco na mucosite gastrointestinal. O estudo discute a aplicação promissora do cinamal-deído, um fitoquímico ativo encontrado em espécies de canela como o IFA em nano-formulações para o tratamento de efeitos adversos da quimioterapia oncológica cuja a fisiopatologia de base é de origem inflamatória. Como plataforma para abordagem, utilizamos a  mucosite intestinal induzida por quimioterápicos, que é uma reação adver-sa da quimioterapia limitante do tratamento oncológico. A base para esta aplicação se dá pelos achados que o cinamaldeído é detentor de atividades biológicas relevantes, o que envolve suas atividades antioxidantes, anti-inflamatória e moduladoras de vias in-tracelulares imunes, que podem contribuir com uma redução dos efeitos adversos da quimioterapia e, portanto, melhor o prognóstico da quimioterapia oncológica. No entan-to, o cinamaldeído bem como outros bioprodutos, é repleto de desafios para sua aplica-ção clínica, como baixa solubilidade aquosa e alta volatilidade, o que pode comprome-ter sua eficácia. Neste estudo,  discutimos estratégias que podem ser aplicadas para superar essa limitação, especialmente com técnicas  escalonáveis e com viabilidade de cadeia produtiva como a complexação com ciclodextrinas que podem incrementar a solubilidade e melhorar sua estabilidade além de sua eficácia terapêutica. Assim, esta revisão pretende contribuir para estabelecer na literatura,  uma narrativa que possa servir de base para a aprendizagem acerca do desenvolvimento de nanocomplexos de metabólitos secundários-ciclodextrina, utilizando o cinamaldeído como plataforma de exemplificação.
A formação docente na perspectiva da educação ambiental: currículo, políticas públicas e práticas educativas
Authors: Barbosa Eliane Soares Santos
Published: October 2024

Os fundamentos que subsidiam a transversalidade da temática Meio Ambiente e Saúde, introduzida nos Parâmetros Curriculares Nacionais (PCN), em 1996, são essenciais para integrar essas questões ao ensino. Contudo, a Educação Ambiental alcançou maior relevância legislativa com a promulgação da Lei nº 9.795/1999, que instituiu a Política Nacional de Educação Ambiental, definindo sua inserção nos diversos níveis e modalidades de ensino. Apesar disso, raramente se encontram projetos educativos que implementem essas diretrizes de maneira eficaz. A transversalidade e a interdisciplinaridade, quando presentes, costumam ser centradas em temas específicos, e muitas dessas iniciativas acabam sendo passageiras e pontuais. Diante desse cenário, a presente pesquisa tem como objetivo principal investigar como integrar a Educação Ambiental (EA) de forma mais eficaz no currículo escolar, visando que se consiga assegurar um ensino-aprendizagem que torne os estudantes aptos a compreender não apenas o conceito de meio ambiente, mas também seus processos e dinâmicas socioambientais. Portanto, é necessário discutir a solidez de projetos educacionais e as interconexões que promovam a cidadania ambiental. Este artigo apresenta uma revisão bibliográfica que explora obras e estudos sobre o Ensino de Educação Ambiental, o Currículo escolar e a relevância da formação de professores nesse contexto. O texto destaca tanto os desafios quanto as oportunidades que surgem na integração da Educação Ambiental nos currículos, enfatizando a importância da formação docente.
Oral Testosterone Therapy in Hypogonadal Men: A Comprehensive Systematic Review and Meta-Analysis of Safety, Efficacy, and Secondary Health Outcomes
Authors:   Professor of Medicine, Endocrinology and Clinical Nutrition/Independent Medical Scientist, Brazil, Borges Julian Yin Vieira
Published: October 2024

Objective: To conduct a systematic review and meta-analysis to evaluate the safety and efficacy of oral testosterone therapy in hypogonadal men. The primary outcome is the assessment of safety, focusing on cardiovascular risks, liver toxicity, and prostate safety. Secondary outcomes include evaluations of bone mass, cardiovascular benefits, cognitive function, and potential reductions in mortality. Methods: A systematic search was conducted using databases such as PubMed, Embase, and Cochrane Library, identifying peer-reviewed studies published until August 2024. The search included randomized controlled trials (RCTs), cohort studies, and large clinical trials. The studies involved a total of 3,183 hypogonadal men. Data were extracted and analyzed to assess primary and secondary outcomes. Statistical methods for meta-analysis included fixed-effects and random-effects models to calculate pooled estimates and assess heterogeneity. Results: The analysis included 11 studies, encompassing a total of 3,183 hypogonadal men. Oral testosterone therapy demonstrated a safety profile comparable to other testosterone replacement therapy (TRT). No significant increase in liver toxicity was observed, supported by studies showing no liver damage after long-term oral testosterone undecanoate (TU) administration. Cardiovascular safety results were mixed; some studies noted minor increases in systolic blood pressure (SBP), but there was no consistent evidence of a significant increase in major cardiovascular events compared to other TRT forms. The prostate safety profile was consistent with existing TRT modalities, with only minor increases in prostate-specific antigen (PSA) levels noted. Secondary outcomes were generally favorable: bone density improved, fat mass was reduced, and there were indications of cognitive benefits, although these findings varied across studies. However, the evidence for mortality reduction was inconclusive, with no strong data supporting a significant effect of oral testosterone on reducing mortality. Conclusion: Oral testosterone therapy appears to be a safe and effective treatment for hypogonadal men, with a risk profile comparable to other TRT forms. It offers potential benefits in bone health and cognitive function but requires careful monitoring of cardiovascular health and prostate safety during treatment. The findings suggest that oral testosterone therapy can be a valuable option for hypogonadal men, though long-term studies are needed to better understand its full range of effects, particularly concerning mortality and cardiovascular outcomes.
State of Jharkhand - Nature's haven of medicinal plants
Authors: Siddiqui Mahtab
Published: October 2024

The State of Jharkhand abounds in the bounties of Nature in the form of huge mineral resources, enormous forest wealth and a wide variety of medicinal herbs/plants and spices, capable of successfully curing numerous ailments afflicting human race. In this paper, a modest attempt has been made to identify these immensely valuable gems of medicinal plants and their numerous therapeutical applications. Their proper cultivation, harvesting, tapping, harnessing and processing can transform the face of the sector in the State, economically, socially and environmentally. Some of these rare species are already on the verge of extinction and require immediate Government's attention and initiatives.
Kemampuan Membaca Pemahaman Teks Narasi Non Fiksi Bidang Sosial pada Peserta Didik Kelas V Sekolah Dasar
Authors: Daulay Nur Hayati , Maryono Maryono , Zahyuni Violita
Published: October 2024

Penelitian ini bertujuan untuk mendeskripsikan kemampuan membaca pemahaman teks narasi non fiksi bidang sosial pada peserta didik kelas V SD, beragam kemampuan membaca pemahaman teks narasi non fiksi bidang sosial pada peserta didik dan faktor yang mempengaruhi kemampuan membaca pemahaman teks narasi non fiksi bidang sosial peserta didik. Penelitian ini dilakukan di SDN 111/1 Muara Bulian pada tanggal 3 Maret 2024 hingga 3 Juni 2024. Data penelitian diperoleh dengan cara melakukan observasi, wawancara, tes, dan dokumentasi. Pengumpulan data bertujuan untuk melihat kemampuan membaca pemahaman teks narasi non fiksi bidang sosial peserta didik kelas V SDN 111/1 Muara Bulian. Pendekatan pada penelitian ini menggunakan pendekatan kualitatif dengan jenis penelitian studi kasus. Peneliti memilih pendekatan kualitatif dengan alasan sesuai dengan tujuan penelitian yaitu mendeskripsikan kemampuan membaca pemahaman teks narasi non fiksi bidang sosial pada peserta didik kelas V SDN 111/1 Muara Bulian. Adapun subjek pada penelitian ini adalah peserta didik dan guru kelas V SDN 111/1 Muara Bulian. Data yang diperoleh kemudian dianalisis dengan tahapan pertama reduksi data, tahapan kedua penyajian data, dan tahapan ketiga verifikasi data. Hasil penelitian menunjukkan kemampuan membaca pemahaman teks narasi non fiksi bidang sosial pada peserta didik kelas V SDN 111/1 Muara Bulian beragam. Berdasarkan hasil penelitian yang didapatkan dapat disimpulkan bahwa kemampuan membaca pemahaman teks non fiksi peserta didik kelas V SDN 111/1 Muara Bulian beragam dengan berbegai kategori penilaian.
Peran Budaya Sekolah dalam Meningkatkan Karakter Siswa
Authors: Lawolo Juni Rahmat , Bawamenewi Adrianus , Lase Fatiani , Lase Berkat Persada
Published: October 2024

Penelitian ini bertujuan untuk mengetahui peran budaya sekolah dalam meningkatkan karakter siswa dan kendala yang di hadapi dalam meningkatkan karakter siswa serta bagaimana upaya yang dilakukan dalam mengatasi kendala dalam meningkatkan karakter siswa. Teknik pengumpulan data yang digunakan yaitu observasi, wawancara dan dokumentasi. Hasil penelitian dan pembahasan disimpulkan bahwa: Pertama peran budaya sekolah dalam meningkatkan karakter siswa di SMP Negeri 1 Somolo-molo memiliki peran yang sangat penting dimana melalui budaya sekolah, siswa belajar nilai-nilai yang baik, mengembangkan kebiasaan positif, dan berinteraksi dengan orang lain secara efektif. Dengan adanya budaya sekolah yang baik, siswa jadi lebih tahu mana yang benar dan mana yang salah.   Kedua kendala yang dihadapi dalam meningkatkan karakter siswa melalui budaya sekolah di SMP Negeri 1 Somolo-molo yakni kurangnya kesadaran siswa, kurangnya dukungan orang tua, keterbatasan sumber daya karena terbatasnya anggaran dan fasilitas yang mendukung dalam meningkatkan karakter siswa, kemudian siswa mengakui kurangnya minat siswa atau kurang tertarik dengan kegiatan sekolah. Ketiga upaya yang dilakukan dalam mengatasi kendala dalam meningkatkan karakter siswa  yaitu  menjalin kerja sama yang baik dengan orang tua siswa, memanfaatkan teknologi dengan baik untuk memberikan pembelajaran yang menarik dan relevan dengan minat siswa, mengadakan berbagai kegiatan ekstrakurikuler yang positif untuk menyalurkan minat dan bakat siswa, selalu memberikan contoh yang baik kepada siswa, juga mengajak siswa untuk aktif berpartisipasi dalam kegiatan-kegiatan di kelas dan mengadakan kegiatan yang seru dalam kegiatan sekolah yang positif  agar siswa lebih semangat ikut dan tidak merasa bosan.
Pelaksanaan Pembelajaran Keterampilan Vokasional Membuat Sendal Jepit untuk Anak Tunarungu Kelas XII SLB Dharma Bhakti Dharma Pertiwi Bandar Lampung
Authors: Istiqomah Lilis , Utami Ratna Tri , Vernanda Genesa
Published: October 2024

Penelitian ini bertujuan untuk memperoleh gambaran mengenai vokasional pembuatan sandal jepit. Adapun metode penelitian yang digunakan penelitian ini adalah deskriptif kualitatif. Teknik pengumpulan data yang digunakan dalam penelitian ini adalah observasi, wawancara, dan dokumentasi serta teknik analisis data dalam penelitian ini berupa reduksi data, penyajian data dan penarikan kesimpulan atau verifikasi. Subjek dalam penelitian ini adalah peserta didik tunarungu kelas XII. Peserta didik dalam keteampilan sandal jepit sudah baik dalam melakukan aktivitas sehari-hari dan mampu membaca. Penelitian menunjukkan bahwa pelaksanaan pembelajaran vokasional pembuatan sandal jepit terdiri dari tiga tahap yaitu perencanaan, pelaksanaan dan evaluasi. Pada tahap perencanaan dilakukan dengan penyusunan CP (capaian pembelajaran), TP (tujuan pembelajaran), ATP (alur tujuan pembelajaran), prota (program tahunan), progsem (program semester) dan modul ajar. Dalam pelaksanaannya, guru menggunakan metode ceramah, tanya jawab dan demonstrasi. Dan tahap selanjutnya yaitu evaluasi dilakukan dengan melalui penilaian secara objektif terhadap kemampuan peserta didik dalam mengenal alat dan bahan membuat sandal jepit sehingga nantinya anak mampu mendistribusikan dengan prosedur yang diajarkan oleh guru keterampilan. Berdasarkan hasil penelitian, peserta didik sudah cukup mandiri dengan bimbingan guru keterampilan sandal jepit, hal tersebut dibuktikan dengan kemampuan peserta didik dalam mengikuti prosedur pembuatan sandal jepit baik itu mengenal alat dan bahan yang digunakan dan menghasilkan produk sandal jepit dengan kualitas baik sehingga nantinya anak mampu memasarkan ke masyarakat. Dengan memberikan pembelajaran keterampilan vokasional pembuatan sandal jepit diharapkan peserta didik mampu mengembangkan keterampilan tersebut sebagai bekal di dunia kerja.
Implementasi Sila Kedua Pancasila di Mahad Al-Zaytun Berdasarkan Pasal 2 Undang-Undang Nomor 20 Tahun 2003 Dan Siyasah Dusturiyah
Authors: Partono Partono , Sajali Munawir , Taufiqurachman Taufiqurachman
Published: October 2024

Tujuan dari penelitian ini adalah untuk mengetahui Implementasi sila ke dua Pancasila di Ma’had Al-Zaytun berdasarkan Pasal 2 Undang-undang nomor 20 Tahun 2003 dan Siyasah Dusturiyah. Penulis menggunakan metode penelitian pustaka dengan pendekatan penelitian hukum yang dilakukan secara yuridis normatif. Sumber data yang digunakan adalah Sumber data primer yaitu Pasal 2 Undang-Undang Nomer 20 Tahun 2003, buku Ilmu Hukum dalam simpul Siyasah Dusturiyah Refleksi atas teori dan praktek Hukum Tata Negara di Indonesia Karya Ali Akbar Abaib Mas Rabbani Lubis, M..H, dan Buku Al-Zaytun Sumber Inspirasi Karya Drs. Ch. Robin Simanullang dan sumber data sekunder yaitu, buku, jurnal, dokumen, dan sebagainya. Implementasi Sila kedua Pancasila di Ma’had Al-Zaytun berdasarkan Pasal 2 Undang-undang nomor 20 tahun 2003 menekankan pengembangan karakter melalui kegiatan ekstrakurikuler dan program layanan masyarakat yang mengajarkan Santri tentang pentingnya tanggung jawab sosial dan lingkungan. Dengan pendekatan ini, Santri diajarkan untuk menghargai pendapat satu sama lain, dan musyawarah menjadi metode utama dalam pengambilan keputusan. Ini menciptakan suasana di mana semua suara didengar dan dipertimbangkan, mengajarkan santri tentang pentingnya demokrasi dan partisipasi aktif dalam komunitas. Implementasi Sila kedua Pancasila di Ma’had Al-Zaytun melalui pendekatan Siyasah Dusturiyah., setiap santri, guru, eksponen, karyawan, dan civitas apapun dapat hidup berdampingan tanpa membedakan ras, suku, dan kedudukan. Semua orang dapat hidup bersama dengan saling menghormati sesuai dengan prinsip kemanusiaan yang adil dan beradab.
Peran Negara dan MONUSCO dalam Pemenuhan Keamanan Personal Masyarakat Republik Demokratik Kongo Tahun 2021-2022
Authors: Gulo Steven Jacub , Seba Roberto Octavianus Cornelis , Fretes Christian Herman Johan De
Published: October 2024

Konflik berkepanjangan di Republik Demokratik Kongo mengancam serta merenggut keamanan personal dari masyarakat sipilnya, konflik menyebabkan banyaknya angka kematian, penculikan, kekerasan seksual, yang memicu munculnya banyak masyarakat yang harus mengungsi dikarenakan konflik. Negara memiliki fungsi dan kewajiban mutlak dalam memberikan perlindungan terhadap keamanan personal masyarakatnya, meskipun sudah gagal di tahun-tahun sebelumnya tetap perlu ada peran negara dalam memenuhi keamanan personal masyarakatnya melalui teori keamanan kritis yang dipopulerkan oleh Ken Booth, PBB juga merespon melalui MONUSCO yang memiliki tugas utama dalam memenuhi keamanan personal masyarakat di Republik Demokratik Kongo pada tahun 2021-2022, MONUSCO bergerak sebagai implementasi dari Responsibility to Protect dari sidang umum majelis PBB tahun 2005. Penelitian ini menggunakan metode kualitatif  dengan metode analisis deskriptif dalam menjelaskan Peran dari Negara dan MONUSCO dalam pemenuhan keamanan personal dari masyarakat RD Kongo tahun 2021-2022. Hasil dari penelitian ini menunjukkan bahwa upaya pemenuhan keamanan personal dari kedua aktor tersebut masih belum mampu menghentikan jatuhnya korban jiwa serta kekerasan yang terjadi di negara tersebut.
Penerapan Strategi dan Media Pembelajaran Interaktif Kepada Siswa/I SMK Ammadatulhuda Desa Surya Indah oleh Mahasiswa Kukerta MBKM Universitas Riau
Authors: Mujiono Mujiono , Nugroho Muhammad Adji , Cahyo Mhd Septiyan Dwi , Zahkry Guswita Chandra , Wahyudi Silsia Tristy , Islamiah Din , Hardiani Della Putri , Ashiva Zarra , Hayuni Anjar , Nuroctasha Nuroctasha , Sudma Revo Patria
Published: October 2024

Kuliah Kerja Nyata (Kukerta) MBKM Universitas Riau di Desa Surya Indah, Kecamatan Pangkalan Kuras Kabupaten Pelelawan merupakan salah satu bentuk kegiatan pengabdian Masyarakat dengan memberikan program kerja melalui mata kuliah yang dikonversi. Kegiatan Kukerta dilaksanakan selama 43 hari sejak tanggal 14 juli 2024 hingga tanggal 25 agustus 2024. Salah satu kegiatan program kerja Kukerta yang dilakukan adalah Penerapan Strategi dan Media Pembelajaran Interaktif kepada siswa SMK Ammadatulhuda Desa Surya Indah. Artikel ini membahas kegiatan mahasiswa Kukerta MBKM dalam melaksanakan program kerja konversi mata kuliah Pengolaan Pendidikan kepada siswa SMK Ammdatulhuda. Kegiatan kukerta ini bertujuan untuk meningkatkan motivasi dan minat belajar siswa SMK Ammadatulhuda serta konversi mata kuliah. Kegiatan perencanaan dan pelaksanaan merupakan metode pelaksanaan Kukerta. Dalam kegiatan penerapan strategi dan media pembelajaran ini selain melibatkan para siswa, sekolah beserta guru juga ikut terlibat selama proses kegiatan strategi dan media pembelajaran berlangsung. Hasil yang diperoleh dari diadakannya kegiatan ini adalah makin meningkatnya motivasi dan minat belajar serta suasana pembelajaran yang baru bagi siswa SMK Ammadatulhuda desa surya indah.
Sinergi TNI AL dan Industri Pertahanan dalam Kerja Sama Internasional (Analisa JUDC Indonesia-Singapura 2024)
Authors: Wibawa Astria Boganata Candra , Musani Imam , Wiratama Eska Yosep
Published: October 2024

Jurnal ini menulis sinergi antara Tentara Nasional Indonesia Angkatan Laut (TNI AL) dengan industri pertahanan Indonesia dalam kerangka kerja sama internasional dengan Singapura melalui studi kasus Joint Underwater Defense Capability (JUDC) 2024. Penulisan jurnal ini menggunakan pendekatan deskriptif kualitatif dengan analisis studi kasus untuk memahami kolaborasi strategis dalam pengembangan teknologi pertahanan maritim dan peningkatan kesiapan operasional TNI AL. Temuan menunjukkan bahwa sinergi ini meningkatkan kemampuan deteksi dan respon terhadap ancaman maritim serta memperkuat interoperabilitas antara kedua angkatan laut. Selain itu, JUDC juga mendorong perkembangan industri pertahanan domestik melalui transfer teknologi dan produksi bersama alutsista. Dampak positif dari kerja sama ini terlihat dalam peningkatan stabilitas keamanan maritim di kawasan Asia Tenggara, penurunan insiden perompakan, dan peningkatan kerjasama diplomatik antar negara. Sehingga kesimpulan dari penulisan jurnal ini adalah bahwa kolaborasi antara TNI AL dan industri pertahanan dalam kerangka kerja sama internasional merupakan langkah strategis yang signifikan dalam menghadapi ancaman keamanan maritim dan memperkuat kapabilitas pertahanan nasional. Studi ini juga menyoroti pentingnya kerjasama multilateral dalam menghadapi tantangan keamanan yang kompleks dan dinamis di kawasan.
AKTIVITAS POSITIF EKSTRAKURIKULER BACA TULIS AL-QURAN DALAM MENINGKATKAN PEMBELAJARAN PAI DI SEKOLAH MENENGAH PERTAMA 4 MERANGIN
Authors: Marzuki Muslimah,
Published: October 2024

Aktivitas positif dari kegiatan baca tulis Al-Quran pada SMP Negeri 4 Merangin ditandai dengan perubahan sikap dan perilaku siswa-siswi SMP Negeri 4 Merangin yang dapat mengembangkan potensi diri dan membentuk karakter sopan santun baik di lingkungan sekolah selama pembelajaran dan pergaulan terhadap teman, guru serta karyawan disekolah yang sesuai dengan nilai-nilai Agama Islam dan tujuan dari pembelajaran PAI di sekolah. Aktivitas positif dari pelajaran PAI bagi siswa-siswi di SMP Negeri 4 Merangin dapat dilihat selama proses pembelajaran berlangsung, dengan mengamati dan menilai setiap tingkah laku siswa-siswi dan perkembangan berbagai aspek yang berhubungan dengan penerapan nilai-nilai agama diantaranya aspek kognitif melalui peningkatan pengetahuan, aspek afektif merupakan sikap dan perilaku yang ditunjukkan serta psikomotorik melalui gerakan atau perilaku selama proses pembelajaran.