bluuebunny/crossref_metadata_2025 huggingface dataset:
Quality of life of colorectal cancer survivors in a Ghanaian population
Authors: Yorke Joseph , Acheampong Emmanuel , Batu Emmanuella Nsenbah , Obirikorang Christian , Yeboah Francis Agyemang , Asamoah Evans Adu
Published: November 2019

Objective

We collected data to evaluate the quality of life of patients who have survived between one and 8 years from the diagnosis of colorectal cancer.

Data description

We collected quality of life (QoL) data from colorectal patients who were diagnosed between 2009 and 2015 at the Komfo Anokye Teaching Hospital (KATH) and have survived until January 2017. The dataset consists of patients’ demographic data, clinicopathological characteristics, and QoL data. The validated QoL instruments for data curation was an adopted version of the European Organization for Research and Treatment of Cancer (EORTC) QLQ-C30 and the EORTC QLQ-CR29. The QLQ-C30 was a 30-item general cancer instrument with 5 functional subscales, and 9 symptom subscales, whereas the QLQ-CR29 was a 29-item scale that consisted of 3 functional QOL subscales and 14 symptom subscales, that are associated with colorectal cancer and its treatment. The QoL instrument was coded such that higher scores indicated increased function and better QoL, and higher symptom scores represent worse symptoms.
Development of a quantitative PCR assay for detection of redside shiner (Richardsonius balteatus) from environmental DNA
Authors: Hoy Marshal S. , Ostberg Carl O.
Published: November 2019

Objective

A quantitative PCR (qPCR) assay for the detection of redside shiner (Richardsonius balteatus) environmental DNA (eDNA) was designed as a side product of a larger project aimed at using eDNA to determine the presence and geographic extent of native and non-native fishes in the reservoirs and associated tributaries above the three mainstem dams (Ross, Diablo, Gorge) on the Skagit River, Washington, USA. The eDNA survey results can be used to help guide additional sampling efforts that include traditional sampling methods, such as electrofishing and netting.

Results

The redside shiner qPCR assay (RSSCOI_540-601) was validated by testing for sensitivity using redside shiner genomic DNA from three different populations and by testing for specificity against 30 potentially sympatric species. No non-target amplification was observed in our validation tests. We then evaluated the assay on field-collected water samples where there are known populations of redside shiner and a negative control site where the target species is known to be absent. The field-collected water samples tested positive at the redside shiner sites and tested negative at the negative control site. The assay could provide resource managers with an effective means for surveying and monitoring redside shiner populations.
Seesaw nystagmus with internuclear ophthalmoplegia from bilateral dorsomedial pons and left thalamus infarction: a case report
Authors: Zhang Qian , Li Jian
Published: November 2019

Background

We describe for the first time the clinical features and mechanisms of a bilateral dorsomedial pons and left thalamus infarction with seesaw nystagmus and internuclear ophthalmoplegia.

Case presentation

A 62-year-old Chinese man was hospitalized for sudden-onset dizziness, diplopia, and gait disturbance. A neurological examination revealed seesaw nystagmus and internuclear ophthalmoplegia. Magnetic resonance imaging disclosed an acute infarction confined to the bilateral dorsomedial pons and left thalamus. Subsequently, 2 weeks of antithrombotic therapy led to an improvement in his symptoms.

Conclusions

This case illustrates that the acute onset of seesaw nystagmus and internuclear ophthalmoplegia accompanied by risk factors for cerebrovascular diseases are highly suggestive of brainstem infarction.
Estimation of the within-herd transmission rates of bovine viral diarrhoea virus in extensively grazed beef cattle herds
Authors: Han Jun-Hee , Weston Jenny F. , Heuer Cord , Gates M. Carolyn
Published: November 2019

Many research groups have developed mathematical models to simulate the dynamics of BVDV infections in cattle herds. However, most models use estimates for within-herd BVDV transmission rates that are either based on expert opinion or adapted from other dairy herd simulation models presented in the literature. There is currently little information on the transmission rates for BVDV in extensively grazed beef herds partly due to the logistical challenges in obtaining longitudinal data of individual animal’s seroconversion, and it may not be appropriate to apply the same transmission rates from intensive dairy herds given the significant differences in herd demographics and management. To address this knowledge gap, we measured BVDV antibody levels in 15 replacement heifers in each of 75 New Zealand beef breeding farms after their first calving and again at pregnancy scanning or weaning to check for seroconversion. Among these, data from 9 farms were used to infer the within-herd BVDV transmission rate with an approximate Bayesian computation method. The most probable within-herd BVDV transmission rate was estimated as 0.11 per persistently infected (PI) animal per day with a 95% highest posterior density interval between 0.03 and 0.34. This suggests that BVDV transmission in extensively grazed beef herds is generally slower than in dairy herds where the transmission rate has been estimated at 0.50 per PI animal per day and therefore may not be sufficient to ensure that all susceptible breeding females gain adequate immunity to the virus before the risk period of early pregnancy for generating new PI calves.
Object tracking framework with Siamese network and re-detection mechanism
Authors: Li Daqun , Yu Yi , Chen Xiaolin
Published: November 2019

To improve the deficient tracking ability of fully-convolutional Siamese networks (SiamFC) in complex scenes, an object tracking framework with Siamese network and re-detection mechanism (Siam-RM) is proposed. The mechanism adopts the Siamese instance search tracker (SINT) as the re-detection network. When multiple peaks appear on the response map of SiamFC, a more accurate re-detection network can re-determine the location of the object. Meanwhile, for the sake of adapting to various changes in appearance of the object, this paper employs a generative model to construct the templates of SiamFC. Furthermore, a method of template updating with high confidence is also used to prevent the template from being contaminated. Objective evaluation on the popular online tracking benchmark (OTB) shows that the tracking accuracy and the success rate of the proposed framework can reach 79.8% and 63.8%, respectively. Compared to SiamFC, the results of several representative video sequences demonstrate that our framework has higher accuracy and robustness in scenes with fast motion, occlusion, background clutter, and illumination variations.
Ulam stability of Caputo q-fractional delay difference equation: q-fractional Gronwall inequality approach
Authors: Butt Rabia Ilyas , Abdeljawad Thabet , Alqudah Manar A. , Rehman Mujeeb ur
Published: November 2019

In this article, we discuss the existence and uniqueness of solution of a delay Caputo q-fractional difference system. Based on the q-fractional Gronwall inequality, we analyze the Ulam–Hyers stability and the Ulam–Hyers–Rassias stability. An example is provided to support the theoretical results.
Maximum principle and its application to multi-index Hadamard fractional diffusion equation
Authors: Ren Xueyan , Wang Guotao , Bai Zhanbing , El-Deeb A. A.
Published: November 2019

This study establishes some new maximum principle which will help to investigate an IBVP for multi-index Hadamard fractional diffusion equation. With the help of the new maximum principle, this paper ensures that the focused multi-index Hadamard fractional diffusion equation possesses at most one classical solution and that the solution depends continuously on its initial boundary value conditions.
Basic theory of differential equations with linear perturbations of second type on time scales
Authors: Zhao Yige , Sun Yibing , Liu Zhi , Bai Zhanbing
Published: November 2019

In this paper, we develop the theory of differential equations with linear perturbations of second type on time scales. An existence theorem for differential equations with linear perturbations of second type on time scales is given under$\mathscr{D}$D-Lipschitz conditions. Some fundamental differential inequalities on time scales, which are utilized to investigate the existence of extremal solutions, are also presented. The comparison principle on differential equations with linear perturbations of second type on time scales is established. Our results in this paper extend and improve some well-known results.
On type 2 degenerate Bernoulli and Euler polynomials of complex variable
Authors: Kim Taekyun , Kim Dae San , Jang Lee-Chae , Kim Han-Young
Published: November 2019

Recently, Masjed-Jamei, Beyki, and Koepf studied the so-called new type Euler polynomials without using Euler polynomials of complex variable. Here we study the type 2 degenerate cosine-Euler and type 2 degenerate sine-Euler polynomials, which are type 2 degenerate versions of these new type Euler polynomials, by considering the degenerate Euler polynomials of complex variable and by treating the real and imaginary parts separately. In addition, we investigate the corresponding ones for Bernoulli polynomials in the same manner. We derive some explicit expressions for those new polynomials and some identities relating to them. Here we note that the idea of separating the real and imaginary parts separately gives an affirmative answer to the question asked by Hacène Belbachir.
Immune pressures drive the promoter hypermethylation of neoantigen genes
Authors: Yi Ming , Dong Bing , Chu Qian , Wu Kongming
Published: November 2019

Cancer cells with strong immunogenicity are susceptible for elimination by cancer immunoediting, while the subpopulations with weak immunogenicity survive. As a result, a subset of cancer cells evade the immune attack and evolve into overt clinical lesions. During cancer evolution, it has been well established that multiple alterations such as the dysfunction of antigen presentation machinery and the upregulation of immunosuppressive signals (e.g. PD-L1) play important roles in immune escape. Recently, promoter hypermethylation of neoantigen genes has been proposed to be a vital mechanism of immunoediting. This epigenetically mediated immune evasion enriches the mechanisms of carcinogenesis.
Alexithymia predicts maladaptive but not adaptive emotion regulation strategies in adolescent girls with anorexia nervosa or depression
Authors: Sfärlea Anca , Dehning Sandra , Keller Lena Katharina , Schulte-Körne Gerd
Published: November 2019

Background

Among adolescent girls, anorexia nervosa (AN) and major depression (MD) are common and often comorbid mental health problems. Both disorders are characterised by difficulties in recognising and verbalising (alexithymia) as well as regulating one’s emotions, but research in adolescent patients is scarce and little is known about the relation between alexithymia and difficulties in emotion regulation. The aims of this study were to investigate alexithymia and emotion regulation skills in adolescents with AN, adolescents with MD, and healthy adolescents, and to determine whether alexithymia functions as a predictor for emotion regulation skills.

Methods

Emotion regulation strategies, alexithymia, and depressive symptoms were assessed by questionnaire measures in 12–18 year old girls with AN (n = 26), girls with MD (n = 25), and healthy girls (n = 35). Groups were compared with respect to the these variables and multiple regression analyses were calculated separately for adaptive and maladaptive emotion regulation strategies in order to examine if alexithymia predicted emotion regulation over and above age and depressive symptoms.

Results

Girls with AN or MD both reported using adaptive emotion regulation strategies less frequently and maladaptive emotion regulation skills more frequently as well as higher levels of alexithymia compared to healthy girls. Alexithymia positively predicted maladaptive emotion regulation strategies, while depressive symptoms negatively predicted adaptive emotion regulation strategies.

Conclusions

The results suggest that different mechanisms may underlie the lack of adaptive and the surplus of maladaptive emotion regulation strategies in adolescent psychiatric patients.
Dual-energy spectral CT characteristics in surgically resected lung adenocarcinoma: comparison between Kirsten rat sarcoma viral oncogene mutations and epidermal growth factor receptor mutations
Authors: Li Meng , Zhang Li , Tang Wei , Duan Jian-Chun , Jin Yu-Jing , Qi Lin-Lin , Wu Ning
Published: November 2019

Background

Kirsten rat sarcoma viral oncogene homolog (KRAS) and epidermal growth factor receptor (EGFR) are the two most frequent and well-known oncogene of lung adenocarcinoma. The purpose of this study is to compare the characteristics measured with dual-energy spectral computed tomography (DESCT) in lung adenocarcinoma patients who have KRAS and EGFR gene mutations.

Methods

Patients with surgically resected lung adenocarcinoma (n = 72) were enrolled, including 12 patients with KRAS mutations and 60 patients with EGFR mutations. DESCT quantitative parameters, including the CT number at 70 keV, the slopes of the spectral attenuation curves (slope λ HU), normalized iodine concentration (NIC), normalized water concentration (NWC), and effective atomic number (effective Z), were analyzed. A multiple logistic regression model was applied to discriminate clinical and DESCT characteristics between the types of mutations.

Results

The KRAS mutation was more common in people who smoked than the EGFR mutation. Nodule type differed significantly between the KRAS and EGFR groups (P = 0.035), and all KRAS mutation adenocarcinomas were solid nodules. Most DESCT quantitative parameters differed significantly between solid nodules and subsolid nodules. CT number at 70 keV, slope λ HU, NIC, and effective Z differed significantly between the KRAS and EGFR groups (P = 0.006, 0.017, 0.013 and 0.010) with solid lung adenocarcinoma. Multivariate logistic analysis of DESCT and clinical features indicated that besides smoking history, the CT value at 70 keV (OR = 0.938, P = 0.009) was significant independent factor that could be used to differentiate KRAS and EGFR mutations in solid lung adenocarcinoma.

Conclusions

DESCT would be a potential tool to differentiate lung adenocarcinoma patients with a KRAS mutation from those with an EGFR mutation.
Lesion measurement on a combined “all-in-one” window for chest CT: effect on intra- and interobserver variability
Authors: Snoeckx Annemiek , Cant Jeroen , Franck Caro , Luyckx Elisa , Carpentier Ken , Nicolay Simon , Van Hoyweghen Astrid , Spinhoven Maarten J. , Vuylsteke Pieter , Parizel Paul M.
Published: November 2019

Purpose

A newly developed image processing technique fuses conventional windows into a single ‘All-In-One’ (AIO) window. This study aims to evaluate variability of CT measurement of lesions in thoracic oncology patients on this novel AIO-window.

Methods

Six radiologists with different levels of expertise measured 368 lesions of various size, origin and sharpness. All lesions were measured twice on the AIO-window and twice on the conventional window settings. Intraclass correlation coefficients and Bland-Altman plots were used to assess intra- and interobserver variability.

Results

Overall intra-observer agreement for lesion diameters on the AIO-window and conventional window settings was 0.986 (95% Confidence interval (CI): 0.983–0.989) and 0.991 (95% CI 0.989–0.993) respectively. For interobserver agreement this was 0.982 (95% CI 0.979–0.985) (AIO) and 0.979 (95% CI 0.957–0.982) (conventional). For both the AIO and conventional windows, intra- and interobserver agreement were dependent on size, sharpness and reader experience. Measurement variability decreased with increasing lesion size. Regarding sharpness, inter- and intra-observer agreement ranged from 0.986–0.989 (AIO) and 0.985–0.992 (conventional) for well-defined lesions and from 0.978–0.983 (AIO) and 0.974–0.991 (conventional) for ill-defined lesions.

Conclusions

Lesion diameters were consistently smaller on the AIO-window compared to conventional window settings. Overall intra- and interobserver variability rates were similar for the AIO-window and conventional window settings. We conclude that the AIO-window offers a reliable and reproducible alternative for measurement of thoracic lesions.
Efficiency of rice husk ash and fly ash as reactivity materials in sustainable concrete
Authors: Amin Mohamed , Abdelsalam Bassam Abdelsalam
Published: November 2019

Many environmental problems occur due to rice husk burning and emissions from coal-fired power stations. This paper presents the recycling of rice husk ash (RHA) and fly ash (FA) from power plants as reactivity materials for producing sustainable (green) concrete. This research aims to investigate the efficiency of RHA and FA replacement ratios on fresh and hardened properties of concrete mixtures. The experimental program consisted of 21 concrete mixtures, which were divided into three groups. The cementitious material contents were 350, 450 and 550 kg m−3for groups one, two and three, respectively. The replacement ratios from the cement content were 10, 20 and 30% respectively, for each recycle material (RHA and FA). The slump and air contents of fresh concrete were measured. The compressive strength, splitting tensile strength, flexural strength, modulus of elasticity and bond strength of hardened concrete as mechanical properties were also analyzed. The compressive strength was monitored at different ages: 3, 7, 28, 60 and 90 d. The water permeability test of hardened concrete as physical properties was conducted. Test results showed that the RHA and FA enhanced the mechanical and physical properties compared with the control mixture. The cementitious content of 450 kg m−3exhibited better results than other utilized contents. In particular, the replacement ratios of 10 and 30% of RHA presented higher mechanical properties than those of FA for each group. The water permeability decreased as the cementitious content increased due to the decrease in air content for all mixtures. The water permeability loss ratios increased as the cementitious content decreased.
Paraneoplastic β Cell Dedifferentiation in Nondiabetic Patients with Pancreatic Cancer
Authors: Wang Yichen , Ni Qicheng , Sun Jiajun , Xu Min , Xie Jing , Zhang Jun , Fang Yuan , Ning Guang , Wang Qidi
Published: November 2019

Context

Beta-cell dedifferentiation was recently proposed as a mechanism of β-cell dysfunction, but whether it can be a trigger of β-cell failure preceding hyperglycemia in humans is uncertain. Pancreatic cancer can cause new-onset diabetes, yet the underlying mechanism is unknown.

Objective

To investigate whether β-cell dedifferentiation is present in nondiabetic pancreatic ductal adenocarcinoma (PDAC) patients, we examined pancreatic islets from 15 nondiabetic patients with benign tumors (control) and 15 nondiabetic PDAC patients.

Design

We calculated the number of hormone-negative endocrine cells and evaluated important markers of β-cell dedifferentiation and function in the paraneoplastic islets. We assessed tumor-related inflammatory changes under the pancreatic cancer microenvironment and their influence on β-cell identity.

Results

We found nearly 10% of nonhormone expressing endocrine cells in nondiabetic PDAC subjects. The PDAC islets were dysfunctional, evidenced by low expression of Glucose transporter 2 (GLUT2) and Urocortin3 (UCN3), and concomitant upregulation of Aldehyde Dehydrogenase 1 Family Member A3 (ALDH1A3) expression and proinsulin accumulation. Pancreatic cancer caused paraneoplastic inflammation with enhanced tissue fibrosis, monocytes/macrophages infiltration, and elevated inflammatory cytokines. Moreover, we detected β-cell dedifferentiation and defects in GSIS in islets exposed to PANC-1 (a cell line established from a pancreatic carcinoma of ductal origin from a 56-year-old Caucasian male)-conditioned medium. In a larger cohort, we showed high prevalence of new-onset diabetes in PDAC subjects, and fasting blood glucose (FBG) was found to be an additional useful parameter for early diagnosis of PDAC.

Conclusions

Our data provide a rationale for β-cell dedifferentiation in the pathogenesis of pancreatic cancer–associated diabetes. We propose that β-cell dedifferentiation can be a trigger for β-cell failure in humans, before hyperglycemia occurs.
Lar maintains the homeostasis of the hematopoietic organ in Drosophila by regulating insulin signaling in the niche
Authors: Kaur Harleen , Sharma Shiv Kumar , Mandal Sudip , Mandal Lolitika
Published: November 2019

Stem cell compartments in metazoa get regulated by systemic factors as well as local stem cell niche-derived factors. However, the mechanisms by which systemic signals integrate with local factors in maintaining tissue homeostasis remain unclear. Employing the Drosophila lymph gland, which harbors differentiated blood cells, and stem-like progenitor cells and their niche, we demonstrate how a systemic signal interacts and harmonizes with local factor/s to achieve cell type-specific tissue homeostasis. Our genetic analyses uncovered a novel function of Lar, a receptor protein tyrosine phosphatase. Niche-specific loss of Lar leads to upregulated insulin signaling, causing increased niche cell proliferation and ectopic progenitor differentiation. Insulin signaling assayed by PI3K activation is downregulated after the second instar larval stage, a time point that coincides with the appearance of Lar in the hematopoietic niche. We further demonstrate that Lar physically associates with InR and serves as a negative regulator for insulin signaling in the Drosophila larval hematopoietic niche. Whether Lar serves as a localized invariable negative regulator of systemic signals such as insulin in other stem cell niches remains to be explored.
The Paf1 complex and P-TEFb have reciprocal and antagonist roles in maintaining multipotent neural crest progenitors
Authors: Jurynec Michael J. , Bai Xiaoying , Bisgrove Brent W. , Jackson Haley , Nechiporuk Alex , Palu Rebecca A. S. , Grunwald Hannah A. , Su Yi-Chu , Hoshijima Kazuyuki , Yost H. Joseph , Zon Leonard I. , Grunwald David Jonah
Published: November 2019

Multipotent progenitor populations are necessary for generating diverse tissue types during embryogenesis. We show the RNA polymerase-associated factor 1 complex (Paf1C) is required to maintain multipotent progenitors of the neural crest (NC) lineage in zebrafish. Mutations affecting each Paf1C component result in near-identical NC phenotypes; alyron mutant embryos carrying a null mutation in paf1 were analyzed in detail. In the absence of zygotic paf1 function, definitive premigratory NC progenitors arise but fail to maintain expression of the sox10 specification gene. The mutant NC progenitors migrate aberrantly and fail to differentiate appropriately. Blood and germ cell progenitor development is affected similarly. Development of mutant NC could be rescued by additional loss of positive transcription elongation factor b (P-TEFb) activity, a key factor in promoting transcription elongation. Consistent with the interpretation that inhibiting/delaying expression of some genes is essential for maintaining progenitors, mutant embryos lacking the CDK9 kinase component of P-TEFb exhibit a surfeit of NC progenitors and their derivatives. We propose Paf1C and P-TEFb act antagonistically to regulate the timing of the expression of genes needed for NC development.
The plakin domain of C. elegans VAB-10/plectin acts as a hub in a mechanotransduction pathway to promote morphogenesis
Authors: Suman Shashi Kumar , Daday Csaba , Ferraro Teresa , Vuong-Brender Thanh , Tak Saurabh , Quintin Sophie , Robin François , Gräter Frauke , Labouesse Michel
Published: November 2019

Mechanical forces can elicit a mechanotransduction response through junction-associated proteins. In contrast to the wealth of knowledge available for focal adhesions and adherens junctions, much less is known about mechanotransduction at hemidesmosomes. Here, we focus on the C. elegans plectin homolog VAB-10A, the only evolutionary conserved hemidesmosome component. In C. elegans, muscle contractions induce a mechanotransduction pathway in the epidermis through hemidesmosomes. We used CRISPR to precisely remove spectrin repeats (SRs) or a partially hidden Src homology 3 (SH3) domain within the VAB-10 plakin domain. Deleting the SH3 or SR8 domains in combination with mutations affecting mechanotransduction, or just the part of SR5 shielding the SH3 domain, induced embryonic elongation arrest because hemidesmosomes collapse. Notably, recruitment of GIT-1, the first mechanotransduction player, requires the SR5 domain and the hemidesmosome transmembrane receptor LET-805. Furthermore, molecular dynamics simulations confirmed that forces acting on VAB-10 could make the central SH3 domain, otherwise in contact with SR4, available for interaction. Collectively, our data strongly indicate that the plakin domain plays a central role in mechanotransduction and raise the possibility that VAB-10/plectin might act as a mechanosensor.
Emphysematous Pyelonephritis: A single center review
Authors: Irfaan Albeerdy Mohammad , Shaikh Nadeem Ahmed , Jamshaid Anila , Qureshi Abdul Hafeez
Published: November 2019

Background and Objective: Emphysematous pyelonephritis (EPN) is a rare, life-threatening necrotizing renal parenchymal infection. Traditional management of EPN with nephrectomy had a mortality of 40-50%. The purpose of this case series was to assess the management, biochemical factors, and outcome of EPN patients.

Methods: In this retrospective study, patients admitted to The Indus Hospital, Karachi with a diagnosis of EPN from January 2010 to February 2019, were grouped according to the Huang Tseng Classification (HTC). Their biochemical parameters, sensorium states and outcomes were recorded and analysed.

Results: Twenty patients were reviewed (9 males). No mortality was recorded. 11 patients (55%) were treated conservatively with only intravenous antibiotics and eight patients underwent an intervention: minimally invasive with drain placement in six patients, and invasive in four patients (two underwent subsequent nephrectomy, and two patients had nephrectomy only). One patient left against medical advice. All patients had decreased serum creatinine levels and total leucocyte counts on discharge.

Conclusion: EPN can be successfully managed conservatively for HTC Grade-1 and 2. Conservative treatment may be tried in higher grades, but poor response should lead to prompt escalation of treatment.

doi: https://doi.org/10.12669/pjms.36.ICON-Suppl.1728

How to cite this:Irfaan AM, Shaikh NA, Jamshaid A, Qureshi AH. Emphysematous Pyelonephritis: A single center review. Pak J Med Sci. Special Supplement ICON 2020. 2020;36(1):S83-S86 doi: https://doi.org/10.12669/pjms.36.ICON-Suppl.1728

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Features of Profession Oriented Foreign Language Teaching in a Non-Linguistic University
Authors: Mizyurova E.
Published: November 2019

The article considers a profession oriented foreign language as one of the main components of the professional training of a modern specialist. The optimal ways of eff ective learning contribute to the development of communication skills for the successful solution of various professional tasks.
Development of the Theory of Intellectual Capital in the Digital Economy
Authors: Лосева Ольга , Loseva Ol'ga
Published: November 2019

The article describes the main features of the digital economy that determine the development of the theory of intellectual capital from the standpoint of human-oriented approach. The interpretation of the concept "human intellectual capital" is offered, its structure at the level of the worker and the organization is described. Approaches and models of human intellectual capital assessment taking into account natural and artificial components of human intelligence are presented.
Modern Trends in the Introduction and Promotion of Innovations in Russian Universities
Authors: Пилипенко П. , Pilipenko P. , Тимошенко Г. , Timoshenko G.
Published: November 2019

The article describes the category of "innovation in education", its role in the national economy, the main types of innovation in Russian universities. The analysis of the features of the current stage of innovative development of higher education is carried out. The modern trends of introduction and promotion of innovations in Russian universities are revealed.
FORMAS DE DIFUSIÓN INSTITUCIONAL DEL CONOCIMIENTO: UN PAPEL PARA RELIME
Authors: Cantoral Uriza Ricardo
Published: November 2019

En editoriales previos se han tratado temáticas diversas, que van desde la pertenencia de Relime en índices, directorios, repositorios y bases de datos de revistas internacionales y su reflejo en los indicadores bibliométricos, hasta la necesidad de participar en la formación de una comunidad académica. Si bien la revista nace en Latinoamérica, impulsada por un grupo pionero, se le concibió e impulsó como una estrategia regional que se propuso jugar el papel de una publicación científica de clase mundial: ser global desde lo local.
PUNTOS MEDIOS EN TRIÁNGULO: UN CASO DE CONSTRUCCIÓN DE SIGNIFICADO PERSONAL Y MEDIACIÓN SEMIÓTICA
Authors: Perry Patricia , Camargo Leonor , Samper Carmen
Published: November 2019

Presentamos un estudio de investigación interpretativa en el que a través de una entrevista no estructurada se rastrea la construcción de significado personal de un hecho geométrico por parte de un estudiante de grado séptimo; el proceso fue mediado semióticamente por la entrevistadora. El análisis, presentado a manera de viñetas, se hace desde una perspectiva semiótica basada en la teoría del signo triádico de Peirce. Se evidencia que la introducción a una actividad de índole científica puede beneficiarse notablemente de la mediación semiótica de un experto, en particular, para que el estudiante aclare, relacione y exprese sus ideas.
Os limites do enunciado apofântico e a posição ontológica da lógica: uma interpretação do §33 de Sein und Zeit
Authors: Da Silva Felipe Maia
Published: November 2019

O §33 cumpre um papel central na analítica existencial do Dasein em Sein und Zeit, uma vez que introduz a destruição fenomenológica do conceito tradicional – lógico – de lógos, preparando o caminho para uma análise construtiva da Rede. Nosso objetivo neste artigo é expor as principais camadas argumentativas da destruição lógico-ontológica ali presente, que apontam justamente para os limites ou as origens existenciais do enunciado apofântico (Aussage), realçando, paralelamente, o diálogo velado de Heidegger com a tradição – e especialmente com Aristóteles.
Efficacy of an antigravity treadmill on functional outcome in non-operatively treated pelvic fractures: a prospective pilot study
Authors: Henkelmann Ralf , Schäfer Michael , Höch Andreas , Leps Christian , Busse Martin , Josten Christoph , Böhme Jörg
Published: November 2019

Background/Aims

Treating pelvic fractures non-operatively is possible. The immobilisation stage of recovery requires different adjustment processes compared to those used in operative treatment. The aim of the present study was to prove the additional benefit an antigravity treadmill can have on patients with non-operatively treated pelvic fractures.

Methods

A prospective pilot study, including patients with non-operatively treated pelvic fractures as the intervention group and healthy volunteers as a control group, was undertaken. Patients of the intervention group participated in a training session with an antigravity treadmill every 3 days for a total of 40 days, in addition to physiotherapy, lymph drainage massage and manual therapy. Patients were evaluated using a dynamic gait index, and a numeric rating scale on three successive dates, to assess their pain. A standardised gait analysis was also carried out.

Results

The intervention group comprised 9 patients, while 33 patients made up the control group. All patients completed the protocols and experienced a significant decrease in pain and increase of mobility. Gait analysis showed that by the 40-day follow-up, patients in the intervention group had regained almost normal gait patterns when compared to the control group. At each time point, a significant improvement in patients' gait patterns could be seen.

Conclusions

The results concurred with previous studies, suggesting that the antigravity treadmill is safe and that recovery to almost normal gait patterns is possible, while the comparison to a healthy group strengthened the data. The present prospective study thus showed promising results regarding the efficacy of the antigravity treadmill, despite study limitations.
Antibody reaction of leptospirosis in asymptomatic feral boars, Thailand
Authors: Prompiram Phirom , Poltep Kanaporn , Sangkaew Nongluck
Published: November 2019

Aim: This study aimed to determine the proportion of exposure to leptospirosis and evaluate the degree of serovar antibody reaction in feral boars.

Materials and Methods: A total of 58 sera obtained from feral boars in Khao Prathab Chang Wildlife Breeding Center, Ratchaburi, Thailand, were screened for leptospirosis exposure by microscopic agglutination test, conducted with a reference panel of 23 pathogenic serovars and a non-pathogenic serovar.

Results: Overall exposure rate of 62.07% was found in the studied population. An antibody reaction presented in 18 of 24 leptospiral serovars. Among the seropositive, Ballum serovar showed predominant exposure in the feral boar population.

Conclusion: The results show a relatively high exposure to leptospirosis and the predominant serovar was Ballum followed by Canicola, the first finding in feral boars in Thailand. It has been revealed that feral boars act as a natural reservoir host of leptospirosis. There should be more concern about public health problems in leptospirosis arising where feral boars appear.
Az emberi méltóság és a progresszió realisztikus koncepciója felé
Authors: Szücs Gergely László
Published: November 2019

Tanulmányomban azt az utat rekonstruálom, amelyet Axel Honneth a Jürgen Habermas neve által fémjelzett kritikai hagyománytól eltávolodva megtett. Tanulmányom fókuszában Honnethnek a Nancy Fraserrel közösen jegyzett 2003-as Umverteilung oder Anerkennung? című kötetben megjelenő gondolatmenete áll. Az itt kirajzolódó kritikai elmélet nagy teret enged egy kettős interpretáció lehetőségének: Honneth elemzése egyszerre olvasható klasszikus társadalomfilozófiai gondolatmenetként és szociológiai diagnózisként. Tanulmányomban azonban nem a Fraserrel folytatott vitában érintett konkrét társadalmi problémákat (elosztási igazságosság, vagy az új társadalmi mozgalmak kérdése) fogom másfél évtized távlatából újraértékelni, inkább az elméleti konstrukció előfeltevéseit állítom figyelmem középpontjába. Első körben felvázolom a kritikai elméletnek azt a Lukácstól Habermasig tartó elméleti hagyományát, amellyel szemben Honneth a saját koncepcióját kidolgozza. Ezután Honneth nézőpontjából felvázolom annak a társadalmi-kulturális kontextusnak (a polgári-kapitalista elismerési rendnek) a főbb vonásait, amelyben az igazságosság elveit felmutatja. Ezután két kérdés szempontjából teszem próbára Honneth igazságosság-koncepcióját. Egyrészt: vajon biztos szilárd igazságosságkritériumokhoz jutunk-e a reális elismerési folyamatok és interakciók tanulmányozásával? Másrészt: a modern ember minden tipikus sérelme megragadható-e az individualizált elismerés-elmélet keretein belül? A felmerülő kérdésekre két Honnethnél kirajzolódó megközelítés: az emberi méltóság szempontját előtérbe helyező és a társadalmi progresszió perspektíváját kiemelő kritikai elmélet-modell szempontjából igyekszem válaszolni. Végül jelzem az így kirajzolódó kritikai elmélet-típusok lehetséges korlátait.
Diskurzusetikák a kilencvenes években: Habermas és MacIntyre
Authors: Paár Tamás
Published: November 2019

A cikk Habermas és MacIntyre összehasonlítását végzi el diskurzusetikai szempontból. Először az összehasonlítasukra irányuló korábbi próbálkozásokat (illetve hiányosságaikat) értékeli, Habermas MacIntyre-kritikáját is ide értve, majd az etikájukban meglévő közös vonásokat emeli ki. Ez után három olyan kérdést vizsgál, amelyek mentén érdemes lehet összehasonlítani és esetenként részben korrigálni az álláspontjukat. Ezek: az igazság és az ideális kommunikációs közösség viszonyának kérdése, a jogok idealitásának kérdése, valamint az ideális és reális politikai filozófiák különbségének problémája.
Umkehr und Erneuerung
Authors: Polak Regina
Published: November 2019

Ausgehend von einer sozialwissenschaftlichen Beschreibung zeitgenössischer »Migration« und der damit verbundenen gesellschaftspolitischen Herausforderung interpretiert die Autorin dieses heterogene Phänomen geschichtstheologisch als »Zeichen der Zeit«. Im Anschluss daran zeigt sie auf bibeltheologischer Grundlage, dass Migration ein »Lernort des Glaubens« war und ist und identifiziert exemplarische Lernfelder, die Europa zu Umkehr und Erneuerung aufrufen: Migration als Prozess der Befreiung, als Lernort im Umgang mit Fremden und Fremdheit, sowie die Bedeutung von Lernen und Erinnerung. Die Autorin lädt dazu ein, Migrantinnen und Migranten als Botschafterinnen und Botschafter wahrzunehmen, die zu Lern- und Umkehrprozessen aufrufen.
Jüdisch-Christliche Grundlagen Europas
Authors: Huber Wolfgang
Published: November 2019

Wolfgang Huber beleuchtet in seinem Aufsatz den Beitrag des christlich-jüdischen Erbes zu Europa als einer weniger geographischen als vielmehr kulturellen Größe. Dabei trägt er zum einen den Ambivalenzen der Beziehungsgeschichte zwischen Judentum und Christentum Rechnung. Zum anderen skizziert er aus evangelischer Perspektive anhand der theologischen Konzepte von Schöpfung, Gnade, Liebe, Hoffnung und Umkehr zentrale Elemente einer gemeinsamen Tradition. Dies führt ihn dazu, gegenüber der üblichen Fokussierung auf - von beiden Religionen geprägte - »europäische Werte« vielmehr den Begriff der Würde als Leitidee starkzumachen, aus dem er dann wiederum exemplarische, dem Würdegedanken entsprechende Werte ableitet.
Im Namen der Emanzipation
Authors: Opratko Benjamin
Published: November 2019

Was macht das Bild von Muslim_innen als rückständige und bedrohliche Andere so anschlussfähig? Welche gesellschaftlichen Widersprüche und Konflikte werden in antimuslimischen Diskursen verarbeitet? Benjamin Opratko untersucht das scheinbare Paradox eines Rassismus, der im Namen der Emanzipation artikuliert wird. Seine hegemonietheoretische Analyse zeigt: Der antimuslimische Rassismus übersetzt die Unsicherheit darüber, ob die Emanzipationskämpfe nach 1968 tatsächlich gewonnen wurden, in die Vorstellung, dass Muslim_innen das Errungene bedrohen. In diesem Mythos repräsentieren muslimische Andere eine überwunden geglaubte Vergangenheit. Ihre Abwertung im Namen der Emanzipation entpuppt sich als historizistischer Rassismus.
Slow Side of the Divide?
Authors: Kania-Lundholm Magdalena
Published: November 2019

Older ICT non-users are often considered vulnerable and potentially socially and digitally excluded group. More recently age-based digital divides have been questioned by scholars aiming to provide a more nuanced understanding of the relationship between old age and technology non-use. Following this path, this article takes the experiences of being an older non- and/or seldom-ICT user and their potential exclusion as point of departure to talk about ideas and understandings of digital technologies and social change. The goal is to empirically explore and understand how the ideas and experiences of ICT nonusage are shared, and negotiated, among older non- and seldom-ICT users. The lived experience of different waves of mediatisation is a specific position in the life course allowing older people to reflect back upon changes prompted by technological development. The empirical data consist of six focus group interviews conducted in Sweden in 2017 with 30 older (65+) non- and seldom-users of ICT between the ages of 68 and 88 years. The results of the analysis show that by describing the ideas and experiences of non- and/or seldom-ICT use, the informants offer a broader reflection on social change and an ambivalent picture of social acceleration. They agree namely that digitalisation is an inevitable process but argue simultaneously that several practices connected to it are not necessarily making our lives easier. Participants experience the socio-technological development in the past 30 years as a very fast one, while adjustment to it deems to occur in a rather slow and weary way. It could be suggested that the nexus of old age on the one hand and non/seldom-ICT usage on the other, as well as their position in life, offer a perspective that can challenge the idea that technological development, ICT access and use are synonymous with efficiency, convenience and inclusion.
Technology and In/equality, Questioning the Information Society
Authors: Henwood Flis , Wyatt Sally
Published: November 2019

At the beginning of the 21st century, we co-edited a book called Technology and In/equality, Questioning the information Society. In that book, we focused on access and control of media technology, education and skills with a particular focus on gender and global economic development. The editors and contributors were all committed to approaching teaching and research about digital technologies and society from an interdisciplinary perspective. In this article, we reflect on how the debates about digital inequalities have developed over the past 20 years, and on our current understanding of “technology” and “in/equality,” the key terms in the title of the book. In this article, we examine what has stayed the same and what has changed, through the lens of gender. We argue that while digital technologies have clearly changed, inequalities have persisted. Contrary to popular belief, access is still an issue for the global south, as well as for marginalised communities throughout the world. We also show how gender inequalities and hierarchies are reproduced in digital spaces, demonstrating that even where women have equal access, possibilities for discrimination and oppression remain. We conclude by arguing that there remain important tasks for scholars of technology and new media, namely to monitor the material and symbolic significance of new technological developments as they emerge and to examine the ways in which they may reflect and re-produce social inequalities.
João Barbalho school group: place for promotion of education in hygienic standards (Pernambuco, 1922-1931)
Authors: Arantes Adlene Silva
Published: November 2019

We seek to understand the medical orientation to promote hygienic education in the João Barbalho school, a structure created to be the model of a republican school institution in Pernambuco. The period covers the creation of the Group and the process of expansion of these institutions in Pernambuco. Required documents, reports of school groups, educational legislation, and hygiene theses of the studied period were analyzed. This research is based theoretically and methodologically on the assumptions of cultural history, and studies related to the history of education in Brazil. We perceive that Pernambuco school groups were formed late compared to groups from other Brazilian states. To ensure the proper functioning guidelines, should be followed: the practice of physical education, anthropometric examinations, and intelligence tests to establish the profile of students for the constitution of homogeneous classes intellectually, physically and racially.
La Educación especial en Chile, en la perspectiva del Dr. Jaime Caiceo Escudero
Authors: Socías Muñoz Estela
Published: November 2019

Basado en las investigaciones realizadas por el Dr. en Ciencias de la Educación, Don Jaime Caiceo Escudero, en relación a la educación especial, que en Chile se le denomina educación diferencial desde 1968 por el Ministerio de Educación, se pretende describir desde sus orígenes hasta la década del ochenta del siglo XX, período en el cual hubo un avance notorio de este tipo de educación en Chile. Se formulará una definición sobre la misma, recurriendo a publicaciones de Dr. Caiceo estudioso de esta área educativa, donde él realiza un análisis sobre el desarrollo histórico de este tipo de educación, desde sus inicios en el año 1852 hasta 1980, dividiéndola en tres grandes períodos, los cuales se describirán y se podrá visualizar la consolidación y las realizaciones científicas (1964-1980), indicando diversas publicaciones, como las del Dr. Luis Bravo Valdivieso. Se indicará, además, la actuación importante que ha tenido después del período estudiado de la Premio Nacional en Educación, Mabel Condemarín; ambas personalidades chilenas son reconocidas a nivel internacional.
As mães de famílias futuras: a Revista o Tico-Tico e a formação das meninas brasileiras (1905-1925)
Authors: Patroclo Luciana Borges
Published: November 2019

O artigo aborda as representações femininas presentes em O Tico-Tico. O recorte temporal, 1905 a 1925, abrange os 20 anos iniciais de circulação do impresso existente até fevereiro de 1962. Os exemplares pesquisados pertencem ao acervo da Hemeroteca Digital da Fundação Biblioteca Nacional. Considerada a primeira revista ilustrada dedicada às crianças brasileiras, sua criação envolveu a ação de intelectuais que apostaram na imprensa não escolar como meio de difusão de conhecimentos e voltada à formação moral da infância. Entre as representações a serem normatizadas estavam às relações de gênero. Nas páginas de O Tico-Tico estavam imersas a perspectiva da mulher como alguém devotado à maternidade e ao casamento. Havia por parte das elites a preocupação em reforçar os princípios da moral burguesa na qual os meninos eram preparados desde cedo para enfrentar o mundo do trabalho e as meninas deveriam receber o conhecimento necessário para ser uma exímia rainha do lar.
Novas articulações da rede de cidades no Brasil: uma análise das heterarquias por meio do sistema de movimento aeroviário
Authors: Teixeira Sérgio Henrique de Oliveira , Catelan Márcio José
Published: November 2019

Diante da ordem global cada vez mais associada às redes de conexões, seus fluxos e suas relações com as cidades, os fixos articuladores nos fornecem elementos para novos entendimentos sobre a rede de cidades. No presente artigo temos como objetivo analisar a relação dos fluxos aéreos e a rede urbana brasileira, tomando como base os dados e as informações dos estudos sobre as regiões de influência das cidades (REGICs). Neste contexto é que lançamos mão da proposta teórico-metodológica sobre a Heterarquia Urbana, um complemento para entendermos as articulações multi e interescalares na rede urbana que explodem ao padrão hierárquico rígido. Neste sentido, o artigo foi estruturado em três focos analíticos: a) à análise do conteúdo da REGIC, mostrando os estudos anteriores e o detalhamento de sua metodologia atual; b) a definição do que compreendemos na relação hierarquia-heterarquia e c) análise do conteúdo espacial por meio do estudo empírico dos fluxos regionais do sistema de movimento aeroviário. A análise, portanto,  mostrou mudanças na estruturação e nas articulações da rede de cidades: os fluxos do sistema de movimento aeroviário revelaram que ao mesmo tempo que há um reforço da hierarquia urbana, também há consolidação de relações complexas nas cidades médias, promovendo a heterarquia urbana.