bluuebunny/crossref_metadata_2025 huggingface dataset:
LC-MS/MS-QTOF Screening and Identification of Phenolic compounds from Ethyl Acetate Fraction of Madhuca longifolia Leaves
Authors: Kendre Nutan , Wakte Pravin
Published: May 2024

Natural products, particularly those derived from plants and microbes, offer an endless supply of unique compounds that can be converted into new pharmaceuticals. Due to their potential health benefits, bioactive components from herbs, particularly phenolics, have recently attracted a lot of interest. One of the multi-use forest tree species, Madhuca longifoliaJ. Koenig. (mahua), is found throughout much of South Asia and offers locals a source of food, fuel, fodder, and other non-timber forest products (NTFPs) in addition to timber. Almost all of this tree's components exhibit its therapeutic qualities.Mahua's phytochemical analysis reveals that it contains high levels of vitamins, alkaloids, sugar, glycosides, proteins, steroids, tannins, flavonoids, saponins, terpenoids, and phenolic compounds. These compounds are responsible for a variety of pharmacological properties, including anti-inflammatory, antioxidant, analgesic, antihyperglycemic, spasmolytic, hepatoprotective, anticonvulsant, anticancer, results of the High-Resolution Liquid Chromatography Mass Spectroscopy (HR-LCMS) analysis showed that plant extracts included a number of pharmaceutically significant chemicals. By comparing the weights and fragmentation patterns of the twenty-four (24) phenolic compounds in this work with those of published libraries, the LC-MS/MS method was used to screen and confirm them. The findings of this research support the usage of this plant as a source of bioactives and the beneficial effects of these compounds on human health.
Analytical Method Development and Validation of Tofisopam in Pure and Pharmaceutical formulation
Authors: S. Gawas Nikhil. , Maste Meenaxi , S. Suryawanshi Shailendra.
Published: May 2024

Tofisopam is an anxiolytic used in treatment of anxiety like disorders, prescribed in the dosage of 50mg to 300mg. As the drug is insoluble in water it is necessary to develop an economical and streamlined liquid chromatography for determination of pure and commercial dosage of Tofisopam. The main objective of the work is to develop and validate an RP-HPLC method for determination of Tofisopam as per ICH guidelines. An RP- HPLC method was devised using 0.1% Orthophosphoric acid in water: methanol in the ration 10:90% v/v and validated for parameters such as system suitability, linearity, limit of detection, limit of quantitation, precision, accuracy, assay, robustness, and ruggedness, as per ICH Guidelines. Tofisopam showed the maximum absorbance at 238nm with good system suitability and linearity was entrenched within the range of 10-60µg/ml, with the regression coefficient of 0.9996. The limit of detection and limit of quantitation were found to be 2.75 µg/ml and 8.855µg/ml respectively. Assay was valuated to be 101%, Accuracy was valuated between 98-103%, and %RSD was less the 2% for precision, robustness and ruggedness, so the method is precise and accurate. The method robustness is demonstrated by insignificant variations in absorption values and mobile phase ratio with deliberate alterations. In accordance with the validation results, the procedure is simple, specific, precise, accurate, robust and suitable for routine analysis of Tofisopam in bulk and commercial products.
Comparison of the Efficacy and Tolerability of Candesartan Cilexetil between Hypertension patients of Muna and Tolaki Ethnicity
Authors: Leorita Mesi , Ikawati Zullies , EndroNugroho Agung , Setyopranoto Ismail
Published: May 2024

There are differences in the efficacy of a drug between ethnicities. Hypertension Treatment Guidelines of JNC 8 recommend not using angiotensin receptor blockers (ARBs) and ACE inhibitors in the black population for first-line therapy. The Tolaki and Muna ethnicities are two indigenous ethnic groups of the Southeast Sulawesi Province of Indonesia. The very different physical characteristics between these two ethnic groups raise the possibility that there are differences in the body's response to antihypertensive ARBs, including candesartan. The study aimed to compare the efficacy and tolerability of candesartan cilexetil monotherapy for one month in hypertensive patients of the Tolaki and Muna ethnicities. Assessment of therapy efficacy includes the proportion of patients achieving the therapeutic target according to JNC 8 and the reduction of blood pressure. Tolerability is assessed based on side effects and adverse drug reactions (ADR) reported by patients. Patients who met the criteria for this study were those who had recently been diagnosed with essential hypertension or hypertension with type 2 diabetes mellitus, were taking candesartan cilexetil (8 mg orally once a day), and had blood pressure values after one month of treatment. Sixty-eight Tolaki ethnic patients and 51 Muna ethnic patients who met the inclusion criteria were included in this study. The results showed that the decrease in systolic and diastolic blood pressure was greater in the Tolaki than those in the Muna ethnicity. The median value of the systolic decrease was -33 ((-10)–(-60)) mmHg for the Tolaki ethnic group and -10 (0–(-20)) mmHg for the Muna ethnic group. The median value of diastolic decline for the Tolaki and Muna ethnicities was -10 (0–(-37)) mmHg and -5 (5–(-20)) mmHg, respectively. The MAP value of the Tolaki ethnic group is 93.30 (80–110), and that of the Muna ethnic group is 110 (96.69–130). The achievement of the target of reducing blood pressure was also significantly higher for the Tolaki than the Muna ethnicities. Complaints felt by some people in both ethnic groups were dizziness, headaches, and feeling weak. Six people in the Muna ethnic group with diabetes mellitus with type 2 experienced hyperkalemia. There was a significant difference in the efficacy of candesartan for one month between Muna and Tolaki ethnic hypertension patients. There was no difference in tolerability between the two ethnic groups.
Differences in Glutamate Dehydrogenase (GLDH) and Other Liver Biochemistry Levels before and after Remdesivir Treatment in COVID-19
Authors: Riadini Dwita , Wardhani Puspa , Puspitasari Yessy , Fuadi M. Robiul , Nadar Indrasari Yulia , Kustiah Kustiah , Pujo Semedi Bambang
Published: May 2024

Background: Remdesivir (RDV) is a broad-spectrum antiviral approved by the Food and Drug Administration (FDA) for the treatment of Covid-19 patients, known to have the potential to cause toxic effects on the liver. Routine monitoring of liver biochemical parameters such as AST, ALT, bilirubin, ALP and GGT, can help detect liver injury. Drug-induced liver injury, according to Hy's law, is characterized by an increase in ALT > 5x ULN, or ALP > 2x ULN, or an increase in ALT > 3x and total bilirubin > 2x ULN, simultaneously. Glutamate dehydrogenase (GLDH) is a sensitive and specific hepatic marker, which can detect liver injury and loss of mitochondrial integrity earlier than other liver biochemical parameters. This study aimed to analyze GLDH levels and liver biochemical parameters before and after RDV therapy in patients with Covid-19. We also analyze several factors that affect liver function and suggest renal function. Methods: This study used an observational analytical with a prospective cohort design, in a population of Covid-19 patients receiving RDV therapy at the infectious emergency department and isolation ward Dr. Soetomo Surabaya for September-November. Consecutive sampling was taken. The subject had drawn blood twice; once before therapy and 5 days after receiving intravenous RDV. GLDH examination is using sandwich ELISA method, while ALT, AST, ALP, GGT, direct and total bilirubin were determined spectrophotometrically. Mann-whitney, the Wilcoxon rank test and Spearman correlation test were used to analyze the data. Results: The number of samples was 34 participants with an average age of 52.47+15.21 years. Concomitant medications were dominated by n-acetylcysteine (94.1%), antioxidants (91.2%) and immunomodulators (82.4%). None of the subjects suffered liver injury induced by RDV according to Hy’s Law. Median GLDH serum levels before RDV treatment 1,14 U/L and after 5 days RDV administration 0,85 U/L (p=0,945), AST (36,4 U/L; 34, 00U/L; p=0,140), ALT (30,43 U/L; 30,20 U/L; p=0,301), DBI (0,15mg/dL; 0,24mg/dL; p=0,090), TBI (0,49mg/dL; 0,50mg/dL; p=0,567), ALP (85,0U/L; 87, 5 U/L; p=0,313) dan GGT (64,5U/L; 71,0U/L; p=0,871). The use of concomitant medication was thought to have protective properties against hepatocytes. Conclusion: After 5 days of RDV treatment, there is no evidence of liver injury. There are no significant differences in GLDH levels and other liver biomarker parameters compared to baseline. There is no difference in delta GLDH levels between groups with and without renal impairment.
Versatile Application of Polymeric Gel Using Gelatin Polymer
Authors: Ahuja Sonam , Sinojia Aayush
Published: May 2024

Fragrance chemicals have been utilized to refresh the air and hide smells since antiquity. Electric air fresheners have a 30% market share, sprays, including aerosol air fresheners, have a 27% market share, car air fresheners have a 16% market share, gel air fresheners have a 9% market share, candle air fresheners and wax melts have a 7% market share, liquid air fresheners have a 6% market share, and others. According to research studies, 34.7% of the population in the United States experienced health concerns such as migraine headaches and respiratory difficulties after being exposed to fragranced items. As a result, there are various studies that show that fragmented items might have harmful health impacts on the general population.Given that air, fresheners have been linked to undesirable negative health impacts, the motivation for developing a greener and healthier method of synthesis of gel air fresheners. The gel air fresheners in this work were created utilizing a simple and green sol-gel reaction that included natural biodegradable polymer gelatin and mogra essence, as well as silver nanoparticles and ampicillin drug for antibacterial gel. In any case, the gel air freshener made from mogra essence is safer for human health than commercially available ones. According to the findings of this investigation, there should be future improvements in stability.Weanalyze the property of the gel from different analysis methods like SEM, TGA, FTIR, and XRD.
EĞİTİM SEKTÖRÜNDE ÖRGÜTSEL İLETİŞİM VE İŞ TATMİNİ İLİŞKİSİ
Authors: Albayrak Hasan Murat , Tiyek Ramazan
Published: May 2024

Bu çalışmanın temel amacı, Milli Eğitim Bakanlığı bünyesinde faaliyet gösteren devlet okulları ve özel okullarda çalışan öğretmenlerin örgütsel iletişim seviyeleri ile iş tatmini arasındaki ilişkiyi belirlemektir. Çalışma örgütsel iletişim ve iş tatmini kavramlarının açıklandığı kuramsal kısım ve araştırmanın anlatıldığı araştırma kısmı olarak iki ana bölümden oluşmaktadır. Çalışmanın evrenini Tekirdağ’ın Çorlu ilçesinde devlet ve özel okullarda görev yapan öğretmenler oluşturmaktadır. Araştırma kapsamında 420’si kamu, 280’i özel okulda çalışan öğretmenler olmak üzere toplamda 700 öğretmenin görüşleri anket yoluyla değerlendirilmiştir. Katılımcıların değerlendirmelerine göre kamu sektöründe ve özel sektörde çalışan öğretmeler için örgütsel iletişim ile iş tatmini arasında pozitif yönlü güçlü bir ilişkinin varlığı tespit edilmiştir.
The Portrayal of Health Disparities in New Jersey’s Local Newspapers: A Text Mining Approach
Authors:   Department of Rehabilitation and Health Services, College of Health and Public Service, University of North Texas, Denton, TX, USA., Obaid Mumtahina
Published: May 2024

This research broadens our understanding of health disparity issues in news media from a unique local perspective. These findings make it clear that the news media significantly influences how the public perceives health disparities.
Comparison of Honey Wax and Olive Oil with 1% Silver Sulfadiazine Dressing on Pain and Wound Healing in Burn
Authors:   Assistant Professor, Urology and Nephrology Research Center, Chronic Diseases (Home Care) Research Center, School of Nursing and Midwifery, Hamadan University of Medical Sciences, Hamadan, Iran., Karampourian Arezou , Feradmal Javad ,   Professor of Biostatistics, Department of Biostatistics, School of Health, Modeling of Noncommunicable Diseases Research Center, Health Sciences & Technology Research Institute, Hamadan University of Medical Sciences, Hamadan, Iran., Amini Roya ,   nstructor of Community Health Nursing, Department of Community Health Nursing, School of Nursing and Midwifery, Chronic Diseases (Homecare) Research Center, Hamadan University of Medical Sciences, Hamadan, Iran., Moradkhani Shirin ,   Associate Professor of Pharmacognosy, Department of Pharmacognosy, School of Pharmacy, Medicinal Plants and Natural Products Research Center, Hamadan University of Medical Sciences, Hamadan, Iran., Alikhani Mohammad Yousef ,   Professor of Medical Bacteriology, Department of Microbiology, School of Medicine, Brucellosis Research Center, Hamadan University of Medical Sciences, Hamadan, Iran., Salimi Rasoul ,   Assistant Professor of Emergency Medicine, Department of Emergency Medicine, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran., Mohammadi Nahid ,   nstructor of Community Health Nursing, Department of Community Health Nursing, School of Nursing and Midwifery, Chronic Diseases (Homecare) Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.
Published: May 2024

Background: Burn is painful, and burn wound healing is a prolonged process. This study aimed to compare the effects of Honey Wax and Olive oil with 1% Silver Sulfadiazine (SSD) dressing on burn wound pain attenuation and healing. Methods: Patients with two burn wounds were randomly divided into two groups. One group was dressed with honey wax and olive oil (intervention) and another wound was dressed with SSD (control). The instruments included the Burn Wound Healing Checklist, Demographic and Clinical questionnaire, and Visual Analogue Scale. Data were analyzed using independent t-test and repeated measures analysis of variance tests in SPSS 23 software.
Evaluation of Community Pharmacist-Based Differentiated Care in HIV/AIDS Management Services in Nigeria from 1980 to 2022: A Narrative Review
Authors:   Madonna University Elele, River State, Nigeria., E Austine Ighorodje , U Eze Daniel ,   David Umahi Federal University of Health Sciences, Uburu, Ebonyi State, Nigeria., Chigozie Victor U ,   David Umahi Federal University of Health Sciences, Uburu, Ebonyi State, Nigeria., Sunday Nduka O ,   Nnamdi Azikiwe University Awka, Anambra State, Nigeria., O Brian Ogbonna ,   Nnamdi Azikiwe University Awka, Anambra State, Nigeria.
Published: May 2024

The World Health Organization promotion of community pharmacist-based global strategy to increase access to ART prompted the differentiated care model to meet the target of HIV/AIDS while maintaining quality of care. Published literature has highlights of the involvement with sparse information on the community pharmacists in Rivers State. This study evaluates the community pharmacist’s involvement in the differentiated care services in the Nigeria setting. This narrative review evaluates the community pharmacist’s differentiated care. Literatures retrieved from computerized databases using related search terms. Data retrieved were entered into Microsoft Excel sheet and summarized to present the differentiated care services and their gaps with the aim of developing interventions to facilitate the management of HIV/AIDS. A total of 263 articles were selected from the 305 articles retrieved (86.2% selection rate). All selected articles fell after the year 1980, indicating the novel implication of differentiated care. Majority of the studies are intervention studies and their reviews. The community pharmacists-base differentiated service delivery is a successful approach to meeting the needs of clients in HIV/AIDS management. The initiation of certain services not currently employed will provide good interventions to a robust HIV/AIDS management in Nigeria.
Targeted Screening for Undiagnosed Chronic Kidney Disease among Asymptomatic Immediate Family Members of Chronic Kidney Disease Patients: Experience from a Teaching Hospital in South Eastern Nigeria
Authors:   Department of Internal Medicine, Nnamdi Azikiwe University Teaching Hospital, Nnewi, Nigeria., C Ozuemba Bartholomew , M Ezeude Chidiebele ,   Department of Internal Medicine, Faculty of Medicine, Nnamdi Azikiwe University, Awka, Nigeria.
Published: May 2024

Background: Chronic Kidney Disease (CKD) is a worldwide epidemic that is associated with a huge morbidity, mortality and high healthcare cost. In Nigeria, the number of patients with CKD progressing to End Stage Renal Disease (ESRD) is increasing. Early screening of individuals who are at risk of CKD has been advocated by several studies because it would reduce the morbidity and mortality associated with late presentation. Studies have found that the immediate family members/First-Degree Relatives (FDRs) of CKD patients have a greater prevalence of CKD compared with the general population and hence should be screened for kidney disease at any available opportunity.
Electrocardiographic Variants of Ventricular Predominance in Arrhythmogenic Cardiomyopathy
Authors:   Clinic of Internal Medicine and Cardiology, UEK Norden, Germany., Peters Stefan
Published: May 2024

Desmoglein-2 and Desmocollin-2 mutations cause different types of arrhythmogenic cardiomyopathy either dominant right, biventricular or dominant left forms. These two mutations present with myocardial cell necrosis and calcification [1,2]. Signs of electrocardiographic right ventricular hypertrophy can be found in more than 50% [3] besides typical ECG criteria of arrhythmogenic cardiomyopathy like right precordial epsilon waves and T-wave inversions [4], QRS fragmentation [5], localized right precordial QRS prolongation [6], terminal activation delay [7], and large Q-waves, small R-waves and T-wave inversion in lead aVR [8].
Reticulocyte Indexes and their Significance
Authors:   Department of Hematology, Faculty of Medical Laboratory Sciences, Port Sudan Ahlia University, Sudan., Abdrhman Bashir
Published: May 2024

A crucial diagnostic tool for assessing, categorizing, and monitoring the effectiveness of anemia treatment is the reticulocyte count. The quality of erythropoiesis is an intrinsic aspect of the pathophysiology of anemia, and the ability of reticulocyte production would be one of the pivotal factors in the quality of erythropoiesis. However, in this minireview, we explain clearly whether the reticulocyte index’s ability is associated with clinical outcomes. There are several ways to describe the reticulocyte count: as a proportion of all red blood cells, as an absolute count, as a corrected count, as the Reticulocyte Production Index (RPI), or as the Immature Reticulocyte Fraction (IRF). Reticulocyte indexes aid in determining the etiology of anemia. They can distinguish between anemia-related causes and other dyserythropoietic problems.
A Case of Dysphagia due to an Esophageal Duplication Cyst in a Difficult Anatomical Site: A Challenging Situation for Endoscopic Treatment
Authors:   Department of Gastroenterology and Hepatology, University General Hospital of Patras, Greece., Sotiropoulos Christos , Konstantakis Christos ,   Department of Gastroenterology and Hepatology, University General Hospital of Patras, Greece., Ampazis Odysseas ,   Department of Gastroenterology and Hepatology, University General Hospital of Patras, Greece., Diamantopoulou Georgia ,   Department of Gastroenterology and Hepatology, University General Hospital of Patras, Greece., Theocharis Georgios ,   Department of Gastroenterology and Hepatology, University General Hospital of Patras, Greece., Triantos Christos ,   Department of Gastroenterology and Hepatology, University General Hospital of Patras, Greece., Thomopoulos Konstantinos ,   Department of Gastroenterology and Hepatology, University General Hospital of Patras, Greece.
Published: May 2024

Esophageal duplication cyst is a rare congenital cyst that results from aberration of the posterior division of the embryonic foregut at the fourth to eighth week of gestation. Most of these cysts become symptomatic in childhood, whereas in adults they are usually an asymptomatic incidental radiographic or endoscopic finding. They may cause symptoms due to compression, rupture and inflammation of the esophagus or the respiratory system and require intervention and treatment when being symptomatic.
Assessment of Occupational Hazards Related Factors among Tobacco Workers
Authors:   Department of Community Health Nursing, Faculty of Nursing, Tishreen University, Lattakia, Syria., Rawan Al-Sayeed , Suzan Zamzam ,   Department of Community Health Nursing, Faculty of Nursing, Tishreen University, Lattakia, Syria.
Published: May 2024

Introduction: The occupational health of workers is the most valued social issue in the society and plays an important role in achieving successful human competence. The current descriptive study aimed to assess the factors related to occupational hazards among tobacco workers in Lattakia in Syria. Methods: The data was collected from an available sample that included 283 workers in Al-Raija factory, using a questionnaire that consisted of three parts (demographic and health data, 19 questions about occupational hazards and diseases, 15 questions about factors related to the work environment, 9 questions about factors related to the nature of work, and 10 questions about factors relating to occupational health services for workers). Results: The results showed that more than half of the workers had respiratory and musculoskeletal problems, in addition to fatigue and stress. The factors related to the work environment and occupational health services were at low level, while the factors related to the nature of work were at medium level. Conclusions: The study recommends the periodic examination of workers, expanding the role of the occupational safety department, and paying attention to the provision and commitment of workers to personal protection means.
TECHNOLOGY OF PSYCHO-REGULATION METHOD IMPLEMENTAION IN ORIENTAL MARTIAL ARTS
Authors: Sofyan Т. Sh. , Vardanyan A.A. , Ter-Grigoryan A.J.
Published: May 2024

To achieve success in sports, various psychological activities are used, including methods of psychoregulation. The study used the most accessible and practical methods of regulating mental state and improving performance in the competitive process.
The purpose of the research is to explore the most widely used methods of psycho-regulation in the field of sports psychology, their instruction at the training phase and their implementation in the pre-competitive and competitive process among karatekas.
Study and analysis of professional literature, application of psycho-regulation methods and breathing exercises and observations.
A number of psychoregulation techniques and methods used by us were trained and applied in Oriental sport Kyokushin karate.
Based on the specifics of the sport, psychoregulation training with 15 karate students was carried out three times a week for a month, lasting from 15 to 20 minutes at the end of the training.
Therefore, training and the use of psychoregulatory techniques in the competitive process were carried out with the karatekas, as a result of which we received positive dynamics.The athletes managed to activate (mobilize) or quiet their emotions on their own, depending on the situation, which allows them to make the most of their training opportunities.
We have used and improved new approaches for the first time, combining traditionalpsychoregulation and meditation techniques in karate, which served as the basis for new researches.
MARKETING COMMUNICATIONS IN BASKETBALL
Authors: Sargsyan N. V.
Published: May 2024

Contemporary society places significant emphasis on sports development today. The use of marketing communications will contribute to the development of basketball. Sports marketing as a distinct domain is a field that quite a lot of people are interested in. Consequently, sport-related events become an opportunity for marketing research and the implementation of various types of marketing activities, fostering an environment conducive to sports marketing exploration and the realization of various marketing initiatives.
The following methods were applied to solve the problem:
1. Literature research
2. Pedagogical observation and experience, questionnaire, interviews, testing
3. Study of consumers, competitors, and competition.
Surveys have revealed that most of the population lacks sufficient information about the sport of basketball. One of the necessary conditions is the presence of the hall. It was indeed obvious that the gyms were not equipped with sufficient facilities. This was due to limited financial resources. The important question was how the public is informed about the ongoing basketball competitions. 75% of information is received via the Internet, 20% through the federation, 5% through friends, and 0% through television. In fact, basketball competitions are not broadcast on television. In the field of television, the main goal of marketing should also be the sale of advertising time.
In the realm of marketing communications in the Republic of Armenia, respondents have consistently highlighted the paramount importance of advertising. Perhaps the specifics of the use of communication forms in the field of physical culture and sports have not been studied well enough. This study seeks to fill this gap focusing on evaluating the effectiveness of these communication methods. It is necessary to present one's own development strategy to make it more attractive and profitable, to indicate the most effective methods to attract potential consumers.
ANALYSIS OF ARMENIAN STUDENTS STRENGTH ENDURANCE INDICATORS
Authors: Gharibyan G.G. , Hakobyan S. , Gasparyan H. S.
Published: May 2024

Strength endurance is considered one of the manifestations of human strength abilities. Indicators of strength endurance give some idea of a person's physical fitness, as well as the functional state of various organs and systems. In the course of the study, it was found that in recent years, specialists in the field of physical education have begun to show quite a lot of interest, especially in the indicators of strength endurance of students. Through this study, an attempt was made to find out the indicators of strength endurance of Armenian students and their compliance with international standards.
The purpose of the study is to figure out the level of strength endurance of Armenian students.
The study was carried out in February 2024 at Yerevan State Medical University named after Mkhitar Heratsi, V. Bryusov State University and the Armenian State Institute of Physical Culture and Sport. The study involved 177 participants. During the study, testing was carried out through 3-minute burpee test.
The following data were obtained from the statistical analysis of the test results: male students - 38.55 (X), 11.97 (σ), 1.29 (m); female students - 34.31 (X), 14.39 (σ), 1.51 (m). From a comparative analysis of the indicators of female and male students, it became clear that female students lag slightly behind the male students in their indicators. The difference is statistically significant (t=2.13, p<0.05) and is 4.24. The data obtained were compared with the data of European (Polish, British, Hungarian, Serbian) students. It turned out that Armenian students have lower level of strength endurance than Europeans. Thus, the international standards of the Burpee 3 m test cannot be applied to Armenian students.
CONTROVERSIAL ISSUES OF PRIMARY SCHOOL EDUCATION
Authors: Ghazaryan F.G. , Khachatryan S.G.
Published: May 2024

The retrospective analysis of the activities of public schools in a number of countries made it possible to note that concrete measures are being implemented here aimed at strengthening the health of students, shaping their personality and preparing them for their future work activities. From that point of view, it is still debatable to start school education early, in other words, from the age of 6.0-6.5. However, how justified is it?
The issues of so-called "school maturity" and the optimal age for primary school were discussed.
Many scientific-methodical literary sources and methods of logical and empirical analysis related to the problem were applied.
The issue of school maturation arose when the tendency to start education of schoolchildren from the age of 6.0 to 6.5 was highlighted. However, from the point of view of functional, psychological, mental and motor training, not all children of that age are already mature and capable of mastering certain knowledge, abilities and skills.
The article describes specific scientific data and results. From 40 to 60% of children are simply not ready for school education. On the other hand, as a result of one-year study, various deviations in the state of health are recorded, motor activity and performance of first-graders are halved. At the same time, intellectuals from different periods claim that it is most effective to start school at the age of 7.
The transition to schooling at the ages of 6.0 and 6.5 has worsened children's health problems. Most of them are not ready for school learning and experience certain difficulties of a psychoemotional, functional and, of course, motor and adaptive nature. The solution of these issues is still considered relevant and up-to-date.
Panorama epidemiológico dos casos de gestantes HIV notificados em Goiás, 2018 a 2022
Authors: Tavares Luciene
Published: May 2024

Objetivo: Descrever o perfil epidemiológico de gestantes portadoras de HIV/AIDS no período de 2018 a 2022 em Goiás. Métodos: Estudo epidemiológico, retrospectivo com abordagem qualitativa, com amostra composta das notificações de HIV gestacional no local e no período. Utilizada a base DBF do Sistema de Informação de Agravos de Notificação (SINAN) do Ministério da Saúde, para o estado de Goiás e regiões de saúde. A coleta de dados foi realizada em fevereiro de 2023. Definição de caso: gestantes que tenham evidência laboratorial de infecção pelo vírus HIV, segundo as normas vigentes do Ministério da Saúde, gestantes com dois testes rápidos de HIV reagentes e um teste ELISA HIV reagente + confirmatório reagente. Análise de dados: o processamento e a análise dos dados foram realizados por meio de seleção das variáveis de interesse para o estudo, faixa etária, raça/cor e escolaridade, utilizando o tabulador de dados TabWin. Realizadas análises de frequências simples, proporções, taxas, média e mediana. Resultados: Foram registradas 552 notificações de gestantes HIV entre os anos analisados. A faixa etária mais acometida pelo HIV/AIDS está compreendida entre o intervalo de 20 a 39 anos; e a raça/cor da pele das gestantes com HIV com maior proporção ao longo do período em análise foi a parda. Percebe-se uma variabilidade na proporção de ignorados, podendo prejudicar a análise. Quanto à escolaridade, a maioria das gestantes HIV, no estado de Goiás, apresentou ensino médio completo. Conclusão: A implementação da prevenção durante a gravidez, o parto e o puerpério é a mais eficaz para reduzir o risco de transmissão vertical. Assim, percebe-se a importância de se conhecer o perfil das gestantes com HIV/AIDS, para que o poder público e os serviços de saúde possam realizar ações voltadas para essa população de acordo com o seu contexto social.
Diagnosticou, tratou: controle da epidemia de HIV na rede municipal especializada em IST/AIDS na cidade de São Paulo
Authors: Oliveira Monique Evelyn de , Oliveira Marcia da Silva , Freitas Silvia Leticia Oliveira Peixoto de , Oliveira Tatiane Pavan Ramos , Abbate Maria Cristina
Published: May 2024

A ampliação do acesso ao diagnóstico do HIV é fundamental para o início do tratamento precoce e a diminuição da carga viral circulante, e a vinculação é uma etapa imprescindível para evitar perda de seguimento entre o Centro de Testagem e Aconselhamento (CTA) e o Serviço de Assistência Especializada (SAE) em IST/AIDS. A Coordenadoria de IST/AIDS facilita o acesso com a disponibilização do tratamento antirretroviral no CTA. Para que seja possível reduzir o tempo entre diagnóstico e início da terapia antirretroviral (TARV), a Rede Municipal Especializada (RME) vem implementando a recomendação da Organização Mundial da Saúde (OMS) de 2013, que é tratar todas as pessoas que vivem com HIV (PVHIV), independentemente da contagem de células TCD4, iniciando o tratamento no mesmo dia do diagnóstico e monitorando esse intervalo. De acordo com a Coordenadoria de IST/AIDS, em 2016, a mediana para o início da TARV após o diagnóstico de HIV na RME IST/AIDS era de 76 dias. Em 2022, essa mediana foi drasticamente reduzida para 4 dias. Como resultado, a cidade tem observado uma queda contínua no número de novos casos de HIV ao longo dos últimos 5 anos. Em 2016, foram notificados 3.761 casos; já em 2021, foram registrados 2.351 casos, com uma redução de 37,5% na incidência do HIV. Já a AIDS teve uma redução ainda mais expressiva: 43,7% entre os anos de 2016 e 2021, passando de 2.408 casos notificados para 1.355. A rede municipal especializada em IST/AIDS de São Paulo tem promovido o acesso à TARV disponibilizando a medicação em tempo hábil, aumentando a qualidade de vida das PVHIV em consonância com as metas globais e contribuindo para o controle da epidemia de HIV/AIDS. Dessa forma, podemos seguir rumo ao controle da epidemia de HIV na cidade de São Paulo.
The profile of childhood glaucoma — results of a 20-year retrospective study
Authors: Sadovnikova N. N. , Brzheskiy V. V. , Zertsalova M. A. , Baranov A. Yu.
Published: May 2024

In 2013, at the 9th Congress of the World Glaucoma Association, a new classification of childhood glaucoma was adopted.

PURPOSE. This study analyzes the profile of childhood glaucoma in accordance with the new classification and evaluates the convenience of its use in clinical and research work.

METHODS. We reviewed the retrospective data of 652 patients (1000 eyes) aged 0 to 18 years with childhood glaucoma who were under observation between 2002 and 2022. The mean follow-up period was 10.4±0.2 years.

RESULTS. The majority of patients had bilateral glaucoma (53.4%). The most common are bilateral manifestations in primary congenital glaucoma (79.7%), juvenile glaucoma (95.8%), secondary glaucoma associated with nonacquired ocular anomalies (54%). The majority of patients in the study were male (363 patients; 56.7%). The most common diagnoses were secondary glaucoma associated with acquired conditions (42.6%), primary congenital glaucoma was diagnosed in 21% of cases. In the vast majority of cases (from 52% to 85%), the treatment of glaucoma was surgical. The maximum number of repeated hypotensive interventions (2.1 operations per eye) was required for patients with primary congenital glaucoma. The results of surgical treatment of secondary childhood glaucoma turned out to be more optimistic — one operation was enough to control glaucoma in 64.6% (62 eyes out of 96) of operated eyes with glaucoma associated with non-acquired ocular anomalies, in 70.7% of cases (29 eyes out of 41) in glaucoma associated with non-acquired systemic conditions, 66.8% in secondary glaucoma associated with acquired conditions (227 eyes out of 340), and in 68.4% of cases in glaucoma following cataract surgery (39 eyes out of 57). In the course of the observation period, 1239 glaucoma interventions were performed. The intervention of choice in all subgroups was filtering surgery. Cyclodestructive procedures were performed significantly more often (p<0.05) in the group with secondary glaucoma associated with acquired conditions. CONCLUSION. The use of a unified classification system is expected to greatly enhance the understanding of this disease, and consequently improve childhood glaucoma management approaches and standards of clinical care in rare types of this disease.>p<0.05) in the group with secondary glaucoma associated with acquired conditions.

CONCLUSION. The use of a unified classification system is expected to greatly enhance the understanding of this disease, and consequently improve childhood glaucoma management approaches and standards of clinical care in rare types of this disease.
Review Study Of Integrating Ai Technology Into Sports Training System
Authors: Su Zhanguo , Ge Shishun , Li Liguang , Su Yiping
Published: May 2024

This article mainly reviews the application of artificial intelligence technology in the field of physical education and its future development trend. The article analyses how AI technology can enhance the quality and efficiency of physical education, providing students with better teaching experience and training effects through intelligent teaching aids, virtual reality technology and big data analysis. The article also highlights the important role of AI technology in promoting the personalized and interdisciplinary development of physical education, demonstrating the potential and prospects for its widespread application in the field of physical education. At the same time, the article also discusses the technical, ethical and privacy challenges facing the application of AI technologies in physical education, and puts forward suggestions for strengthening regulation and norms to ensure the healthy development of the technologies and maximize the benefits to society. In looking at the future development trend, the article points out that AI technology will continue to drive innovation and change in the field of physical education, injecting new vigor into the development of physical education globally.
Research On The Construction Of Competency Model For Chinese Tennis Coaches
Authors: Liu Yan , Cgeng-Te Lin
Published: May 2024

The tennis industry in China is rapidly developing, necessitating a focused effort to enhance the capabilities of tennis coaches to meet the demands of this rapid growth. This study utilizes various research methods including literature review, field surveys, key event technique interviews, Delphi method, and statistical analysis to explore the essential competencies required of Chinese tennis coaches. A competency model consisting of four dimensions and 14 competency indicators has been established, covering cognitive abilities (coaching philosophy, professional experience, analysis, learning), professional skills (training program development, player guidance, motivation), management abilities (communication skills, influence, coordination, problem-solving), and personal traits (achievement motivation, innovation, emotional control). Exploratory factor analysis and confirmatory factor analysis demonstrate that the four-dimensional model exhibits a high level of fit across various fit indices, validating the model effectively. Furthermore, a 36-question assessment scale has been designed to evaluate these competency characteristics. Survey results indicate that Chinese tennis coaches excel primarily in professional skills, followed by personal traits, management abilities, and cognitive capabilities. By employing this model, a structured coach selection approach has been proposed, providing crucial support for enhancing human resource management in Chinese tennis.
Enhancing Recreation Opportunities: A Case Study Of Sports Parks In Yunnan Province, China
Authors: Zhou Cuiyun , Nie Zhenxin
Published: May 2024

This paper explores the construction, development, and socio-economic implications of sports parks in Yunnan Province, China, aiming to foster sustainable recreational experiences. Through an in-depth analysis of three emblematic cases—Kunming Cuihu Sports Park, Dali Ancient City Sports Park, and Lijiang Yulong Sports Park—it elucidates the integration of sports, leisure, and culture within these spaces. Emphasizing characteristic construction, facility maintenance, guided tours, and emergency management, the study underscores their pivotal roles in enhancing visitor experiences. The research delves into the multifaceted impact of sports parks on social development, including the promotion of healthy lifestyles, community cohesion, and local economic growth. By extrapolating insights from these cases, the paper offers valuable references for the planning and management of sports parks in diverse regions. Additionally, it outlines future directions for research, advocating for expanded data collection, nuanced understanding of cultural differences in recreational demands, and leveraging information technology to elevate service quality. These suggestions are poised to drive continuous progress in the field of sports parks, aligning with the evolving needs and aspirations of communities for an enhanced quality of life.
Pelatihan Bahasa Inggris bagi Pelaku Wisata dalam Program MBKM Pembangunan Desa
Authors: Widiatmoko Paulus , Endarto Ignatius Tri , Wati Mega
Published: May 2024

Tujuan pengabdian yang dilakukan melalui program Medeka Belajar Kampus Merdeka Pembangunan Desa (MBKM-PD) ini adalah untuk memenuhi kebutuhan peningkatan penguasaan bahasa Inggris ini karena para mahasiswa tinggal di desa mitra dan bersama-sama dengan masyarakat setempat melakukan inovasi atau penyelesaian masalah yang mereka hadapi. Program ini dilaksanakan secara partisipatif dengan para pelaku wisata. Kebutuhan mereka diakomodasi lewat tahapan wawancara dan pre-test kemampuan untuk mengidentifikasi kebutuhan komunikasi lisan sederhana guna menyambut dan menanggapi tamu asing sesuai dengan bidang kerja mereka (English for Specific Purposes). Sebagai luaran pembelajaran, para peserta pelatihan difasilitasi membuat Vlog tentang deskripsi tempat wisata atau homestay yang mereka kelola dalam Bahasa Inggris, dan mengunggahnya ke laman Youtube. Walaupun ada beberapa kendala pelaksanaan, peserta menanggapi program ini dengan baik, terlihat dari partisipasi pembuatan luaran akhir dan dialog dalam penutupan program.
Riesgos laborales en personal administrativo de UNAN-Managua, FAREM-Matagalpa, Nicaragua, I semestre, 2022
Authors: Aráuz Junieth Tatiana , Hurtado Mario José
Published: May 2024

Este artículo evalúa las condiciones laborales asociadas a riesgos laborales del personal administrativo de la Facultad Regional Multidisciplinaria de Matagalpa, durante el I Semestre 2022. Se desarrolló un estudio descriptivo con enfoque cuantitativo y transversal. El área de estudio fue la Universidad Nacional Autónoma de Nicaragua, UNAN Managua – Facultad Multidisciplinaria Regional Matagalpa en la ciudad de Matagalpa. La muestra es de 45 trabajadores administrativos. Se aplicó una encuesta y se realizó observación directa a través de un Checklist. Los datos fueron procesados en el programa estadístico EPI Info y Microsoft Excel, aplicando análisis, frecuencias y porcentajes, donde se realizaron tablas y gráficos para lograr la triangulación de la información. Los principales resultados muestran que la mayoría de los trabajadores se encuentran en un rango de edad óptimo para el desempeño laboral, con predominio del género masculino y nivel académico universitario, teniendo una antigüedad laboral significativa, esto sugiere un gran potencial para implementar prácticas de seguridad y salud ocupacional de manera efectiva. Si bien las condiciones laborales son en general adecuadas, se identificaron áreas de mejora, como optimizar la disponibilidad y adecuación de los equipos de protección personal. Además, se destaca la importancia de mejorar la ergonomía en determinadas zonas para reducir los riesgos musculoesqueléticos en el futuro, la falta de botiquines de primeros auxilios y la presencia de riesgos relacionados con incendios. Es crucial abordar estas deficiencias y cumplir con regulaciones como la Ley 618 para promover un ambiente de trabajo seguro y eficiente. El estudio destaca la importancia de la formación continua y el desarrollo de una sólida cultura organizacional en materia de higiene y seguridad laboral.
Primeros registros de un pez dorosomátido y de un parásito metazoario de peces en la laguna de Masaya, Nicaragua
Authors: McCrary Jeffrey K. , Jiménez-García María Isabel
Published: May 2024

A pesar de su importancia como hábitats de especies acuáticas prioritarias para medidas de conservación, la fauna de las lagunas cratéricas volcánicas en Nicaragua no es completamente caracterizada. Para ampliar la caracterización de su fauna acuática, se realizaron capturas de peces en la Laguna de Masaya utilizando redes y anzuelos, en dos períodos diferentes y en dos sitios distintos. Se realizó un análisis de tejidos de peces de tres taxones de peces capturados, para la identificación y cuantificación de parásitos metazoarios en la Laguna de Masaya. Este artículo científico reporta el primer registro del sabalete de Chávez, Dorosoma chavesi (Actinopterygii; Dorosomatidae), en la Laguna de Masaya, dentro del Parque Nacional Volcán Masaya, extendiéndose así su rango natural de distribución hacia el oeste de Nicaragua. La especie está registrada en la Lista Roja de la Unión Internacional para la Conservación de la Naturaleza (IUCN) como casi amenazada. Además, este informe presenta el primer registro del parásito metazoario Ascocotyle tenuicollis (Platyhelminthes; Heterophyidae) en la Laguna de Masaya. La especie fue encontrada en el corazón de Amphilophus cf. citrinellus y de Hypsophrys nematopus (ambas Actinopterygii; Cichlidae). No se encontraron parásitos metazoarios en el corazón, mesenterios, ni tracto intestinal de D. chavesi. Se recomienda implementar medidas de protección y monitoreo de especies en elevado estado de conservación en la Laguna de Masaya.
Malnutrición: El impacto de los primeros 1000 días
Authors: Payan José Manuel
Published: May 2024

La nutrición durante los primeros 1000 días de vida, desde la concepción hasta los 2 años, desempeña un papel crucial en el desarrollo y crecimiento, así como en la prevención de problemas de salud a largo plazo. Investigadores se centran en entender el impacto de la nutrición deficiente durante estas etapas, ya que puede resultar en retrasos físicos, cognitivos e inmunológicos con consecuencias significativas en la vida futura del individuo. Se estudian técnicas analíticas como la Resonancia Magnética y la Espectrometría de masa para evaluar el fenotipo metabólico y entender mejor las necesidades nutricionales en cada etapa.
Durante la etapa prenatal, la madre es la única fuente de nutrientes para el embrión y el feto, lo que influye en el tamaño del recién nacido. La restricción del crecimiento intrauterino (RCIU) debido a una nutrición inadecuada puede llevar a deficiencias de aminoácidos y carnitina, lo que justifica estudios sobre la suplementación con estos nutrientes. Además, en la etapa posnatal temprana, la leche materna es fundamental para un desarrollo y crecimiento óptimos, mientras que la malnutrición en la infancia temprana sigue siendo un desafío en países en desarrollo, con deficiencias comunes en micronutrientes como hierro y zinc, lo que aumenta el riesgo de infecciones y mortalidad infantil.